DrugMAP Full Data Download File Title - DrugMAP molecular interaction atlas of all drug in raw format Version 1.01 (2022.07.20) Provided by Lab of Innovative Drug Reasearch and Bioinformatics (IDRB) College of Pharmaceutical Sciences Zhejiang University https://idrblab.org/ Any question about data provided here, please contact with: Dr. Li (lifengcheng@zju.edu.cn) and Dr. Yin (yinjiayi@zju.edu.cn) DI: Drug ID DN: Drug Name MI: Molecule ID MN: Molecule Name MT: Molecule Type MA: Mode of Action RN: Reference Name RU: Reference URL DMMHNU2 DI DMMHNU2 DMMHNU2 DN (S)-(+)-Dimethindene maleate DMMHNU2 MI TTTIBOJ DMMHNU2 MN Histamine H1 receptor (H1R) DMMHNU2 MT DTT DMMHNU2 MA Antagonist DMMHNU2 RN Analytical method for simultaneously measuring ex vivo drug receptor occupancy and dissociation rate: application to (R)-dimethindene occupancy of central histamine H1 receptors. J Recept Signal Transduct Res. 2009;29(2):84-93. DMMHNU2 RU https://pubmed.ncbi.nlm.nih.gov/19308787 DMIAHVU DI DMIAHVU DMIAHVU DN 2-deoxyglucose DMIAHVU MI DTG3T6X DMIAHVU MN Glucose transporter type 1, erythrocyte/brain (SLC2A1) DMIAHVU MT DTP DMIAHVU MA Substrate DMIAHVU RN Glutamine 161 of Glut1 glucose transporter is critical for transport activity and exofacial ligand binding. J Biol Chem. 1994 Aug 12;269(32):20533-8. DMIAHVU RU http://www.jbc.org/content/269/32/20533.long DMIAHVU DI DMIAHVU DMIAHVU DN 2-deoxyglucose DMIAHVU MI DT3BI6S DMIAHVU MN Glucose transporter type 10 (SLC2A10) DMIAHVU MT DTP DMIAHVU MA Substrate DMIAHVU RN Sequence and functional analysis of GLUT10: a glucose transporter in the Type 2 diabetes-linked region of chromosome 20q12-13.1. Mol Genet Metab. 2001 Sep-Oct;74(1-2):186-99. DMIAHVU RU http://www.ncbi.nlm.nih.gov/pubmed/11592815 DMIAHVU DI DMIAHVU DMIAHVU DN 2-deoxyglucose DMIAHVU MI DTA5QI0 DMIAHVU MN Glucose transporter type 12 (SLC2A12) DMIAHVU MT DTP DMIAHVU MA Substrate DMIAHVU RN The human facilitative glucose transporter GLUT12: Expression and regulation in Caco-2 and 3T3-L1cells. DMIAHVU RU https://2017.febscongress.org/abstract_preview.aspx?idAbstractEnc=4424170093096096098098424170 DMIAHVU DI DMIAHVU DMIAHVU DN 2-deoxyglucose DMIAHVU MI DT18YD9 DMIAHVU MN Glucose transporter type 14 (SLC2A14) DMIAHVU MT DTP DMIAHVU MA Substrate DMIAHVU RN The SLC2A14 gene, encoding the novel glucose/dehydroascorbate transporter GLUT14, is associated with inflammatory bowel disease. Am J Clin Nutr. 2017 Dec;106(6):1508-1513. DMIAHVU RU http://www.ncbi.nlm.nih.gov/pubmed/28971850 DMIAHVU DI DMIAHVU DMIAHVU DN 2-deoxyglucose DMIAHVU MI DTUJPOL DMIAHVU MN Glucose transporter type 2, liver (SLC2A2) DMIAHVU MT DTP DMIAHVU MA Substrate DMIAHVU RN GLUT2 (SLC2A2) is not the principal glucose transporter in human pancreatic beta cells: implications for understanding genetic association signals at this locus. Mol Genet Metab. 2011 Dec;104(4):648-53. DMIAHVU RU http://www.ncbi.nlm.nih.gov/pubmed/21920790 DMIAHVU DI DMIAHVU DMIAHVU DN 2-deoxyglucose DMIAHVU MI DT9SQ3L DMIAHVU MN Glucose transporter type 3, brain (SLC2A3) DMIAHVU MT DTP DMIAHVU MA Substrate DMIAHVU RN Ascorbic acid-dependent GLUT3 inhibition is a critical step for switching neuronal metabolism. J Cell Physiol. 2011 Dec;226(12):3286-94. DMIAHVU RU http://www.ncbi.nlm.nih.gov/pubmed/21321936 DMIAHVU DI DMIAHVU DMIAHVU DN 2-deoxyglucose DMIAHVU MI DT4827A DMIAHVU MN Glucose transporter type 4, insulin-responsive (SLC2A4) DMIAHVU MT DTP DMIAHVU MA Substrate DMIAHVU RN Need for GLUT4 activation to reach maximum effect of insulin-mediated glucose uptake in brown adipocytes isolated from GLUT4myc-expressing mice. Diabetes. 2002 Sep;51(9):2719-26. DMIAHVU RU http://www.ncbi.nlm.nih.gov/pubmed/12196464 DMIAHVU DI DMIAHVU DMIAHVU DN 2-deoxyglucose DMIAHVU MI DTS4MKQ DMIAHVU MN Glucose transporter type 6 (SLC2A6) DMIAHVU MT DTP DMIAHVU MA Substrate DMIAHVU RN Functional Properties and Genomics of Glucose Transporters. Curr Genomics. 2007 Apr; 8(2): 113128. DMIAHVU RU http://www.ncbi.nlm.nih.gov/pubmed/18660845 DMIAHVU DI DMIAHVU DMIAHVU DN 2-deoxyglucose DMIAHVU MI DT8SQBG DMIAHVU MN Glucose transporter type 7 (SLC2A7) DMIAHVU MT DTP DMIAHVU MA Substrate DMIAHVU RN Functional Properties and Genomics of Glucose Transporters. Curr Genomics. 2007 Apr; 8(2): 113128. DMIAHVU RU http://www.ncbi.nlm.nih.gov/pubmed/18660845 DMIAHVU DI DMIAHVU DMIAHVU DN 2-deoxyglucose DMIAHVU MI DT2I7BM DMIAHVU MN Glucose transporter type 8 (SLC2A8) DMIAHVU MT DTP DMIAHVU MA Substrate DMIAHVU RN Functional Properties and Genomics of Glucose Transporters. Curr Genomics. 2007 Apr; 8(2): 113128. DMIAHVU RU http://www.ncbi.nlm.nih.gov/pubmed/18660845 DMIAHVU DI DMIAHVU DMIAHVU DN 2-deoxyglucose DMIAHVU MI DTMSNOU DMIAHVU MN Proton-associated sugar transporter A (SLC45A1) DMIAHVU MT DTP DMIAHVU MA Substrate DMIAHVU RN Dysfunction of the Cerebral Glucose Transporter SLC45A1 in Individuals with Intellectual Disability and Epilepsy. Am J Hum Genet. 2017 May 4;100(5):824-830. DMIAHVU RU http://www.ncbi.nlm.nih.gov/pubmed/28434495 DMIAHVU DI DMIAHVU DMIAHVU DN 2-deoxyglucose DMIAHVU MI DTOKC04 DMIAHVU MN Sodium/glucose cotransporter 1 (SLC5A1) DMIAHVU MT DTP DMIAHVU MA Substrate DMIAHVU RN The role of SGLT1 and GLUT2 in intestinal glucose transport and sensing. PLoS One. 2014 Feb 26;9(2):e89977. DMIAHVU RU http://www.ncbi.nlm.nih.gov/pubmed/24587162 DMIAHVU DI DMIAHVU DMIAHVU DN 2-deoxyglucose DMIAHVU MI DTO4FLB DMIAHVU MN Sodium/glucose cotransporter 3 (SLC5A4) DMIAHVU MT DTP DMIAHVU MA Substrate DMIAHVU RN The sodium/glucose cotransport family SLC5. Pflugers Arch. 2004 Feb;447(5):510-8. DMIAHVU RU http://www.ncbi.nlm.nih.gov/pubmed/12748858 DMIAHVU DI DMIAHVU DMIAHVU DN 2-deoxyglucose DMIAHVU MI DT1CP40 DMIAHVU MN Sodium/glucose cotransporter 4 (SLC5A9) DMIAHVU MT DTP DMIAHVU MA Substrate DMIAHVU RN SLC5A9/SGLT4, a new Na+-dependent glucose transporter, is an essential transporter for mannose, 1,5-anhydro-D-glucitol, and fructose. Life Sci. 2005 Jan 14;76(9):1039-50. DMIAHVU RU http://www.ncbi.nlm.nih.gov/pubmed/15607332 DMIAHVU DI DMIAHVU DMIAHVU DN 2-deoxyglucose DMIAHVU MI DTQNIG7 DMIAHVU MN Sodium/glucose cotransporter 5 (SLC5A10) DMIAHVU MT DTP DMIAHVU MA Substrate DMIAHVU RN The sodium/glucose cotransport family SLC5. Pflugers Arch. 2004 Feb;447(5):510-8. DMIAHVU RU http://www.ncbi.nlm.nih.gov/pubmed/12748858 DMYFBMS DI DMYFBMS DMYFBMS DN 99mTc-fanolesomab DMYFBMS MI TTNV1KZ DMYFBMS MN Fucosyltransferase IV (CD15) DMYFBMS MT DTT DMYFBMS RN 2004 approvals: the demise of the blockbuster. Nat Rev Drug Discov. 2005 Feb;4(2):93-4. DMYFBMS RU https://pubmed.ncbi.nlm.nih.gov/15756752 DMVZO01 DI DMVZO01 DMVZO01 DN 99mTc-sestamibi DMVZO01 MI DTSYQGK DMVZO01 MN Multidrug resistance-associated protein 1 (ABCC1) DMVZO01 MT DTP DMVZO01 MA Substrate DMVZO01 RN 99mTc-sestamibi is a substrate for P-glycoprotein and the multidrug resistance-associated protein. Br J Cancer. 1998;77(3):353-8. DMVZO01 RU https://doi.org/10.1038/bjc.1998.57 DMMN36E DI DMMN36E DMMN36E DN Abacavir DMMN36E MI DE017IC DMMN36E MN Alcohol dehydrogenase class-V (ADH6) DMMN36E MT DME DMMN36E MA Metabolism DMMN36E RN A review of the pharmacokinetics of abacavir. Clin Pharmacokinet. 2008;47(6):351-71. DMMN36E RU https://www.ncbi.nlm.nih.gov/pubmed/?term=18479171 DMMN36E DI DMMN36E DMMN36E DN Abacavir DMMN36E MI DTI7UX6 DMMN36E MN Breast cancer resistance protein (ABCG2) DMMN36E MT DTP DMMN36E MA Substrate DMMN36E RN QSAR analysis and molecular modeling of ABCG2-specific inhibitors. Adv Drug Deliv Rev. 2009 Jan 31;61(1):34-46. DMMN36E RU https://doi.org/10.1016/j.addr.2008.10.004 DMMN36E DI DMMN36E DMMN36E DN Abacavir DMMN36E MI TT84ETX DMMN36E MN Human immunodeficiency virus Reverse transcriptase (HIV RT) DMMN36E MT DTT DMMN36E MA Inhibitor DMMN36E RN Quadruple nucleos(t)ide reverse transcriptase inhibitors-only regimen of tenofovir plus zidovudine/lamivudine/abacavir in heavily pre-treated HIV-1 infected patients: salvage therapy or backbone only Curr HIV Res. 2009 May;7(3):320-6. DMMN36E RU https://pubmed.ncbi.nlm.nih.gov/19442129 DMMN36E DI DMMN36E DMMN36E DN Abacavir DMMN36E MI DTCSGPB DMMN36E MN Multidrug resistance-associated protein 4 (ABCC4) DMMN36E MT DTP DMMN36E MA Substrate DMMN36E RN Human intestinal transporter database: QSAR modeling and virtual profiling of drug uptake, efflux and interactions. Pharm Res. 2013 Apr;30(4):996-1007. DMMN36E RU https://doi.org/10.1007/s11095-012-0935-x DMMN36E DI DMMN36E DMMN36E DN Abacavir DMMN36E MI DTUGYRD DMMN36E MN P-glycoprotein 1 (ABCB1) DMMN36E MT DTP DMMN36E MA Substrate DMMN36E RN The transport of anti-HIV drugs across blood-CNS interfaces: summary of current knowledge and recommendations for further research. Antiviral Res. 2009 May;82(2):A99-109. DMMN36E RU https://doi.org/10.1016/j.antiviral.2008.12.013 DMMN36E DI DMMN36E DMMN36E DN Abacavir DMMN36E MI DEYGVN4 DMMN36E MN UDP-glucuronosyltransferase 1A1 (UGT1A1) DMMN36E MT DME DMMN36E MA Metabolism DMMN36E RN A review of the pharmacokinetics of abacavir. Clin Pharmacokinet. 2008;47(6):351-71. DMMN36E RU https://www.ncbi.nlm.nih.gov/pubmed/?term=18479171 DMMN36E DI DMMN36E DMMN36E DN Abacavir DMMN36E MI DEB3CV1 DMMN36E MN UDP-glucuronosyltransferase 2B7 (UGT2B7) DMMN36E MT DME DMMN36E MA Metabolism DMMN36E RN Product characteristics of Triumeq. DMMN36E RU https://www.ema.europa.eu/en/documents/product-information/triumeq-epar-product-information_en.pdf DMOERGM DI DMOERGM DMOERGM DN Abaloparatide DMOERGM MI TTFPD47 DMOERGM MN Parathyroid hormone 1 receptor (PTH1R) DMOERGM MT DTT DMOERGM MA Modulator DMOERGM RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. DMOERGM RU https://www.fda.gov/ DM2RX0I DI DM2RX0I DM2RX0I DN Abametapir DM2RX0I MI TT1GHVO DM2RX0I MN Matrix metalloproteinase (MMP) DM2RX0I MT DTT DM2RX0I MA Inhibitor DM2RX0I RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health Human Services. 2020 DM2RX0I RU https://www.accessdata.fda.gov/drugsatfda_docs/label/2020/206966lbl.pdf DM5WFNP DI DM5WFNP DM5WFNP DN Abarelix DM5WFNP MI TT8R70G DM5WFNP MN Gonadotropin-releasing hormone receptor (GNRHR) DM5WFNP MT DTT DM5WFNP MA Modulator DM5WFNP RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. DM5WFNP RU https://www.fda.gov/ DMSA8RU DI DMSA8RU DMSA8RU DN Abatacept DMSA8RU MI TTFZDNP DMSA8RU MN Activation B7-1 antigen (CD80) DMSA8RU MT DTT DMSA8RU MA Binder DMSA8RU RN Selective modulation of T-cell co-stimulation: a novel mode of action for the treatment of rheumatoid arthritis. Clin Exp Rheumatol. 2009 May-Jun;27(3):510-8. DMSA8RU RU https://pubmed.ncbi.nlm.nih.gov/19604448 DMSA8RU DI DMSA8RU DMSA8RU DN Abatacept DMSA8RU MI TTHGXBU DMSA8RU MN T-lymphocyte activation antigen CD86 (FUN1) DMSA8RU MT DTT DMSA8RU MA Binder DMSA8RU RN Selective modulation of T-cell co-stimulation: a novel mode of action for the treatment of rheumatoid arthritis. Clin Exp Rheumatol. 2009 May-Jun;27(3):510-8. DMSA8RU RU https://pubmed.ncbi.nlm.nih.gov/19604448 DMJO6GV DI DMJO6GV DMJO6GV DN Abciximab DMJO6GV MI TT38RM1 DMJO6GV MN Glycoprotein IIb/IIIa receptor (GPIIb/IIIa) DMJO6GV MT DTT DMJO6GV MA Modulator DMJO6GV RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. DMJO6GV RU https://www.fda.gov/ DM8V75C DI DM8V75C DM8V75C DN ABIRATERONE DM8V75C MI TTRA5BZ DM8V75C MN Steroid 17-alpha-monooxygenase (S17AH) DM8V75C MT DTT DM8V75C MA Modulator DM8V75C RN 2011 FDA drug approvals. Nat Rev Drug Discov. 2012 Feb 1;11(2):91-4. DM8V75C RU https://pubmed.ncbi.nlm.nih.gov/22293555 DMANBZI DI DMANBZI DMANBZI DN Abiraterone acetate DMANBZI MI DE4LYSA DMANBZI MN Cytochrome P450 3A4 (CYP3A4) DMANBZI MT DME DMANBZI MA Metabolism DMANBZI RN Abiraterone for the treatment of metastatic castrate-resistant prostate cancer. Ann Pharmacother. 2012 Jul-Aug;46(7-8):1016-24. DMANBZI RU https://www.ncbi.nlm.nih.gov/pubmed/?term=22714819 DMANBZI DI DMANBZI DMANBZI DN Abiraterone acetate DMANBZI MI DTPFTEQ DMANBZI MN Organic anion transporting polypeptide 2B1 (SLCO2B1) DMANBZI MT DTP DMANBZI MA Substrate DMANBZI RN The impact of statin use on the efficacy of abiraterone acetate in patients with castration-resistant prostate cancer. Prostate. 2017 May;77(13):1303-1311. DMANBZI RU http://www.ncbi.nlm.nih.gov/pubmed/28762529 DMANBZI DI DMANBZI DMANBZI DN Abiraterone acetate DMANBZI MI TTRA5BZ DMANBZI MN Steroid 17-alpha-monooxygenase (S17AH) DMANBZI MT DTT DMANBZI MA Modulator DMANBZI RN CYP17A1 inhibitors in castration-resistant prostate cancer.Steroids.2015 Mar;95:80-7. DMANBZI RU https://www.ncbi.nlm.nih.gov/pubmed/25560485 DMANBZI DI DMANBZI DMANBZI DN Abiraterone acetate DMANBZI MI DE0P6LK DMANBZI MN Sulfotransferase 2A1 (SULT2A1) DMANBZI MT DME DMANBZI MA Metabolism DMANBZI RN Abiraterone for the treatment of metastatic castrate-resistant prostate cancer. Ann Pharmacother. 2012 Jul-Aug;46(7-8):1016-24. DMANBZI RU https://www.ncbi.nlm.nih.gov/pubmed/?term=22714819 DMZT2P0 DI DMZT2P0 DMZT2P0 DN Abobotulinum toxin A DMZT2P0 MI TTZJD1B DMZT2P0 MN Acetylcholine release (Ach rele) DMZT2P0 MT DTT DMZT2P0 MA Modulator DMZT2P0 RN Hughes B: 2009 FDA drug approvals. Nat Rev Drug Discov. 2010 Feb;9(2):89-92. DMZT2P0 RU https://pubmed.ncbi.nlm.nih.gov/20118952 DM7GCVW DI DM7GCVW DM7GCVW DN Acalabrutinib DM7GCVW MI DE4LYSA DM7GCVW MN Cytochrome P450 3A4 (CYP3A4) DM7GCVW MT DME DM7GCVW MA Metabolism DM7GCVW RN FDA label of Acalabrutinib. The 2020 official website of the U.S. Food and Drug Administration. DM7GCVW RU https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/210259s006s007lbl.pdf DM7GCVW DI DM7GCVW DM7GCVW DN Acalabrutinib DM7GCVW MI DEIBDNY DM7GCVW MN Cytochrome P450 3A5 (CYP3A5) DM7GCVW MT DME DM7GCVW MA Metabolism DM7GCVW RN FDA label of Acalabrutinib. The 2020 official website of the U.S. Food and Drug Administration. DM7GCVW RU https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/210259s006s007lbl.pdf DM7GCVW DI DM7GCVW DM7GCVW DN Acalabrutinib DM7GCVW MI TTGM6VW DM7GCVW MN Tyrosine-protein kinase BTK (ATK) DM7GCVW MT DTT DM7GCVW MA Inhibitor DM7GCVW RN 2017 FDA drug approvals.Nat Rev Drug Discov. 2018 Feb;17(2):81-85. DM7GCVW RU https://pubmed.ncbi.nlm.nih.gov/29348678 DMO381I DI DMO381I DMO381I DN Acamprosate DMO381I MI TTAN6JD DMO381I MN Glutamate receptor AMPA (GRIA) DMO381I MT DTT DMO381I MA Agonist DMO381I RN Predicting the effect of naltrexone and acamprosate in alcohol-dependent patients using genetic indicators. Addict Biol. 2009 Jul;14(3):328-37. DMO381I RU https://pubmed.ncbi.nlm.nih.gov/19523047 DMRM3AW DI DMRM3AW DMRM3AW DN Acarbose DMRM3AW MI TTXWASR DMRM3AW MN Intestinal maltase-glucoamylase (MGAM) DMRM3AW MT DTT DMRM3AW MA Modulator DMRM3AW RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. DMRM3AW RU https://www.fda.gov/ DM0TI4U DI DM0TI4U DM0TI4U DN Acebutolol DM0TI4U MI TTR6W5O DM0TI4U MN Adrenergic receptor beta-1 (ADRB1) DM0TI4U MT DTT DM0TI4U MA Antagonist DM0TI4U RN Prediction and experimental validation of acute toxicity of beta-blockers in Ceriodaphnia dubia. Environ Toxicol Chem. 2005 Oct;24(10):2470-6. DM0TI4U RU https://pubmed.ncbi.nlm.nih.gov/16268148 DM0TI4U DI DM0TI4U DM0TI4U DN Acebutolol DM0TI4U MI DECB0K3 DM0TI4U MN Cytochrome P450 2D6 (CYP2D6) DM0TI4U MT DME DM0TI4U MA Metabolism DM0TI4U RN Application of substrate depletion assay to evaluation of CYP isoforms responsible for stereoselective metabolism of carvedilol. Drug Metab Pharmacokinet. 2016 Dec;31(6):425-432. DM0TI4U RU https://www.ncbi.nlm.nih.gov/pubmed/?term=27836712 DM0TI4U DI DM0TI4U DM0TI4U DN Acebutolol DM0TI4U MI DTE2B1D DM0TI4U MN Organic anion transporting polypeptide 1A2 (SLCO1A2) DM0TI4U MT DTP DM0TI4U MA Substrate DM0TI4U RN Fruit juice inhibition of uptake transport: a new type of food-drug interaction. Br J Clin Pharmacol. 2010 Nov;70(5):645-55. DM0TI4U RU http://www.ncbi.nlm.nih.gov/pubmed/21039758 DM0TI4U DI DM0TI4U DM0TI4U DN Acebutolol DM0TI4U MI DTT79CX DM0TI4U MN Organic cation transporter 1 (SLC22A1) DM0TI4U MT DTP DM0TI4U MA Substrate DM0TI4U RN Implications of genetic polymorphisms in drug transporters for pharmacotherapy. Cancer Lett. 2006 Mar 8;234(1):4-33. DM0TI4U RU https://doi.org/10.1016/j.canlet.2005.06.051 DM0TI4U DI DM0TI4U DM0TI4U DN Acebutolol DM0TI4U MI DTUGYRD DM0TI4U MN P-glycoprotein 1 (ABCB1) DM0TI4U MT DTP DM0TI4U MA Substrate DM0TI4U RN Human intestinal transporter database: QSAR modeling and virtual profiling of drug uptake, efflux and interactions. Pharm Res. 2013 Apr;30(4):996-1007. DM0TI4U RU https://doi.org/10.1007/s11095-012-0935-x DMOLNCZ DI DMOLNCZ DMOLNCZ DN ACECLIDINE DMOLNCZ MI TTZ9SOR DMOLNCZ MN Muscarinic acetylcholine receptor M1 (CHRM1) DMOLNCZ MT DTT DMOLNCZ MA Inhibitor DMOLNCZ RN Design, synthesis, and neurochemical evaluation of 5-(3-alkyl-1,2,4- oxadiazol-5-yl)-1,4,5,6-tetrahydropyrimidines as M1 muscarinic receptor agonists. J Med Chem. 1993 Apr 2;36(7):842-7. DMOLNCZ RU https://pubmed.ncbi.nlm.nih.gov/8464038 DMOLNCZ DI DMOLNCZ DMOLNCZ DN ACECLIDINE DMOLNCZ MI TTYEG6Q DMOLNCZ MN Muscarinic acetylcholine receptor M2 (CHRM2) DMOLNCZ MT DTT DMOLNCZ MA Inhibitor DMOLNCZ RN Design, synthesis, and neurochemical evaluation of 5-(3-alkyl-1,2,4- oxadiazol-5-yl)-1,4,5,6-tetrahydropyrimidines as M1 muscarinic receptor agonists. J Med Chem. 1993 Apr 2;36(7):842-7. DMOLNCZ RU https://pubmed.ncbi.nlm.nih.gov/8464038 DMOLNCZ DI DMOLNCZ DMOLNCZ DN ACECLIDINE DMOLNCZ MI TTQ13Z5 DMOLNCZ MN Muscarinic acetylcholine receptor M3 (CHRM3) DMOLNCZ MT DTT DMOLNCZ MA Inhibitor DMOLNCZ RN Design, synthesis, and neurochemical evaluation of 5-(3-alkyl-1,2,4- oxadiazol-5-yl)-1,4,5,6-tetrahydropyrimidines as M1 muscarinic receptor agonists. J Med Chem. 1993 Apr 2;36(7):842-7. DMOLNCZ RU https://pubmed.ncbi.nlm.nih.gov/8464038 DMOLNCZ DI DMOLNCZ DMOLNCZ DN ACECLIDINE DMOLNCZ MI TTQ3JTF DMOLNCZ MN Muscarinic acetylcholine receptor M4 (CHRM4) DMOLNCZ MT DTT DMOLNCZ MA Inhibitor DMOLNCZ RN Design, synthesis, and neurochemical evaluation of 5-(3-alkyl-1,2,4- oxadiazol-5-yl)-1,4,5,6-tetrahydropyrimidines as M1 muscarinic receptor agonists. J Med Chem. 1993 Apr 2;36(7):842-7. DMOLNCZ RU https://pubmed.ncbi.nlm.nih.gov/8464038 DMOLNCZ DI DMOLNCZ DMOLNCZ DN ACECLIDINE DMOLNCZ MI TTH18TF DMOLNCZ MN Muscarinic acetylcholine receptor M5 (CHRM5) DMOLNCZ MT DTT DMOLNCZ MA Inhibitor DMOLNCZ RN Design, synthesis, and neurochemical evaluation of 5-(3-alkyl-1,2,4- oxadiazol-5-yl)-1,4,5,6-tetrahydropyrimidines as M1 muscarinic receptor agonists. J Med Chem. 1993 Apr 2;36(7):842-7. DMOLNCZ RU https://pubmed.ncbi.nlm.nih.gov/8464038 DMZDF0B DI DMZDF0B DMZDF0B DN Aceclofenac DMZDF0B MI DE5IED8 DMZDF0B MN Cytochrome P450 2C9 (CYP2C9) DMZDF0B MT DME DMZDF0B MA Metabolism DMZDF0B RN Metabolism of aceclofenac in humans. Drug Metab Dispos. 1996 Aug;24(8):834-41. DMZDF0B RU https://www.ncbi.nlm.nih.gov/pubmed/?term=8869816 DMZDF0B DI DMZDF0B DMZDF0B DN Aceclofenac DMZDF0B MI TTK0943 DMZDF0B MN Prostaglandin G/H synthase (COX) DMZDF0B MT DTT DMZDF0B MA Modulator DMZDF0B RN Aceclofenac spares cyclooxygenase 1 as a result of limited but sustained biotransformation to diclofenac. Clin Pharmacol Ther. 2003 Sep;74(3):222-35. DMZDF0B RU https://pubmed.ncbi.nlm.nih.gov/12966366 DMH75KV DI DMH75KV DMH75KV DN Acenocoumarol DMH75KV MI DEJGDUW DMH75KV MN Cytochrome P450 1A2 (CYP1A2) DMH75KV MT DME DMH75KV MA Metabolism DMH75KV RN Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. DMH75KV RU https://www.ncbi.nlm.nih.gov/pubmed/?term=19515014 DMH75KV DI DMH75KV DMH75KV DN Acenocoumarol DMH75KV MI DE5IED8 DMH75KV MN Cytochrome P450 2C9 (CYP2C9) DMH75KV MT DME DMH75KV MA Metabolism DMH75KV RN Prediction of pharmacokinetic drug/drug interactions from In vitro data: interactions of the nonsteroidal anti-inflammatory drug lornoxicam with oral anticoagulants. Drug Metab Dispos. 2000 Feb;28(2):161-8. DMH75KV RU https://www.ncbi.nlm.nih.gov/pubmed/?term=10640513 DMH75KV DI DMH75KV DMH75KV DN Acenocoumarol DMH75KV MI DE4LYSA DMH75KV MN Cytochrome P450 3A4 (CYP3A4) DMH75KV MT DME DMH75KV MA Metabolism DMH75KV RN Possible interaction between topical terbinafine and acenocoumarol. Ann Pharmacother. 2009 Nov;43(11):1911-2. DMH75KV RU https://www.ncbi.nlm.nih.gov/pubmed/?term=19843835 DMH75KV DI DMH75KV DMH75KV DN Acenocoumarol DMH75KV MI DEGTFWK DMH75KV MN Mephenytoin 4-hydroxylase (CYP2C19) DMH75KV MT DME DMH75KV MA Metabolism DMH75KV RN Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. DMH75KV RU https://www.ncbi.nlm.nih.gov/pubmed/?term=19515014 DMH75KV DI DMH75KV DMH75KV DN Acenocoumarol DMH75KV MI TTEUC8H DMH75KV MN Vitamin K epoxide reductase complex 1 (VKORC1) DMH75KV MT DTT DMH75KV MA Inhibitor DMH75KV RN Evaluation of a reverse-hybridization StripAssay for the detection of genetic polymorphisms leading to acenocoumarol sensitivity. Mol Biol Rep. 2010 Apr;37(4):1693-7. DMH75KV RU https://pubmed.ncbi.nlm.nih.gov/19562511 DM1SRQT DI DM1SRQT DM1SRQT DN Aceprometazine DM1SRQT MI TTTIBOJ DM1SRQT MN Histamine H1 receptor (H1R) DM1SRQT MT DTT DM1SRQT MA Antagonist DM1SRQT RN Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. DM1SRQT RU https://pubmed.ncbi.nlm.nih.gov/17016423 DMUIE76 DI DMUIE76 DMUIE76 DN Acetaminophen DMUIE76 MI DE4OGUF DMUIE76 MN Cytochrome P450 102A1 (cyp102) DMUIE76 MT DME DMUIE76 MA Metabolism DMUIE76 RN The bacterial P450 BM3: a prototype for a biocatalyst with human P450 activities. Trends Biotechnol. 2007 Jul;25(7):289-98. DMUIE76 RU https://pubmed.ncbi.nlm.nih.gov/17532492 DMUIE76 DI DMUIE76 DMUIE76 DN Acetaminophen DMUIE76 MI DE6OQ3W DMUIE76 MN Cytochrome P450 1A1 (CYP1A1) DMUIE76 MT DME DMUIE76 MA Metabolism DMUIE76 RN Preferred orientations in the binding of 4'-hydroxyacetanilide (acetaminophen) to cytochrome P450 1A1 and 2B1 isoforms as determined by 13C- and 15N-NMR relaxation studies. J Med Chem. 1994 Mar 18;37(6):860-7. DMUIE76 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=8145237 DMUIE76 DI DMUIE76 DMUIE76 DN Acetaminophen DMUIE76 MI DEJGDUW DMUIE76 MN Cytochrome P450 1A2 (CYP1A2) DMUIE76 MT DME DMUIE76 MA Metabolism DMUIE76 RN PharmGKB summary: pathways of acetaminophen metabolism at the therapeutic versus toxic doses. Pharmacogenet Genomics. 2015 Aug;25(8):416-26. DMUIE76 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=26049587 DMUIE76 DI DMUIE76 DMUIE76 DN Acetaminophen DMUIE76 MI DEJVYAZ DMUIE76 MN Cytochrome P450 2A6 (CYP2A6) DMUIE76 MT DME DMUIE76 MA Metabolism DMUIE76 RN Metabolic interactions between acetaminophen (paracetamol) and two flavonoids, luteolin and quercetin, through in-vitro inhibition studies. J Pharm Pharmacol. 2017 Dec;69(12):1762-1772. DMUIE76 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=28872689 DMUIE76 DI DMUIE76 DMUIE76 DN Acetaminophen DMUIE76 MI DE5IED8 DMUIE76 MN Cytochrome P450 2C9 (CYP2C9) DMUIE76 MT DME DMUIE76 MA Metabolism DMUIE76 RN Summary of information on human CYP enzymes: human P450 metabolism data. Drug Metab Rev. 2002 Feb-May;34(1-2):83-448. DMUIE76 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=11996015 DMUIE76 DI DMUIE76 DMUIE76 DN Acetaminophen DMUIE76 MI DECB0K3 DMUIE76 MN Cytochrome P450 2D6 (CYP2D6) DMUIE76 MT DME DMUIE76 MA Metabolism DMUIE76 RN Metabolic interactions between acetaminophen (paracetamol) and two flavonoids, luteolin and quercetin, through in-vitro inhibition studies. J Pharm Pharmacol. 2017 Dec;69(12):1762-1772. DMUIE76 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=28872689 DMUIE76 DI DMUIE76 DMUIE76 DN Acetaminophen DMUIE76 MI DEVDYN7 DMUIE76 MN Cytochrome P450 2E1 (CYP2E1) DMUIE76 MT DME DMUIE76 MA Metabolism DMUIE76 RN Acetaminophen induced acute liver failure via oxidative stress and JNK activation: protective role of taurine by the suppression of cytochrome P450 2E1. Free Radic Res. 2010 Mar;44(3):340-55. DMUIE76 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=20166895 DMUIE76 DI DMUIE76 DMUIE76 DN Acetaminophen DMUIE76 MI DE4LYSA DMUIE76 MN Cytochrome P450 3A4 (CYP3A4) DMUIE76 MT DME DMUIE76 MA Metabolism DMUIE76 RN Metabolic interactions between acetaminophen (paracetamol) and two flavonoids, luteolin and quercetin, through in-vitro inhibition studies. J Pharm Pharmacol. 2017 Dec;69(12):1762-1772. DMUIE76 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=28872689 DMUIE76 DI DMUIE76 DMUIE76 DN Acetaminophen DMUIE76 MI DEIBDNY DMUIE76 MN Cytochrome P450 3A5 (CYP3A5) DMUIE76 MT DME DMUIE76 MA Metabolism DMUIE76 RN Induction of hepatic CYP2E1 by a subtoxic dose of acetaminophen in rats: increase in dichloromethane metabolism and carboxyhemoglobin elevation. Drug Metab Dispos. 2007 Oct;35(10):1754-8. DMUIE76 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=17620348 DMUIE76 DI DMUIE76 DMUIE76 DN Acetaminophen DMUIE76 MI DE4ZHS1 DMUIE76 MN Glutathione S-transferase alpha-1 (GSTA1) DMUIE76 MT DME DMUIE76 MA Metabolism DMUIE76 RN Retinoid X receptor alpha regulates the expression of glutathione s-transferase genes and modulates acetaminophen-glutathione conjugation in mouse liver. Mol Pharmacol. 2005 Dec;68(6):1590-6. DMUIE76 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=16157696 DMUIE76 DI DMUIE76 DMUIE76 DN Acetaminophen DMUIE76 MI DTFI42L DMUIE76 MN Multidrug resistance-associated protein 2 (ABCC2) DMUIE76 MT DTP DMUIE76 MA Substrate DMUIE76 RN Effect of acetaminophen on expression and activity of rat liver multidrug resistance-associated protein 2 and P-glycoprotein. Biochem Pharmacol. 2004 Aug 15;68(4):791-8. DMUIE76 RU http://www.ncbi.nlm.nih.gov/pubmed/15276087 DMUIE76 DI DMUIE76 DMUIE76 DN Acetaminophen DMUIE76 MI TTAWNKZ DMUIE76 MN Norepinephrine transporter (NET) DMUIE76 MT DTT DMUIE76 MA Inhibitor DMUIE76 RN Augmentation effect of combination therapy of aripiprazole and antidepressants on forced swimming test in mice. Psychopharmacology (Berl). 2009 Sep;206(1):97-107. DMUIE76 RU https://pubmed.ncbi.nlm.nih.gov/19517098 DMUIE76 DI DMUIE76 DMUIE76 DN Acetaminophen DMUIE76 MI TTK0943 DMUIE76 MN Prostaglandin G/H synthase (COX) DMUIE76 MT DTT DMUIE76 MA Inhibitor DMUIE76 RN Mechanism of action of paracetamol. Am J Ther. 2005 Jan-Feb;12(1):46-55. DMUIE76 RU https://pubmed.ncbi.nlm.nih.gov/15662292 DMUIE76 DI DMUIE76 DMUIE76 DN Acetaminophen DMUIE76 MI TT3ROYC DMUIE76 MN Serotonin transporter (SERT) DMUIE76 MT DTT DMUIE76 MA Inhibitor DMUIE76 RN Augmentation effect of combination therapy of aripiprazole and antidepressants on forced swimming test in mice. Psychopharmacology (Berl). 2009 Sep;206(1):97-107. DMUIE76 RU https://pubmed.ncbi.nlm.nih.gov/19517098 DMUIE76 DI DMUIE76 DMUIE76 DN Acetaminophen DMUIE76 MI DEYWLRK DMUIE76 MN Sulfotransferase 1A1 (SULT1A1) DMUIE76 MT DME DMUIE76 MA Metabolism DMUIE76 RN Interindividual variability in acetaminophen sulfation by human fetal liver: implications for pharmacogenetic investigations of drug-induced birth defects. Birth Defects Res A Clin Mol Teratol. 2008 Mar;82(3):155-65. DMUIE76 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=18232020 DMUIE76 DI DMUIE76 DMUIE76 DN Acetaminophen DMUIE76 MI DEYGVN4 DMUIE76 MN UDP-glucuronosyltransferase 1A1 (UGT1A1) DMUIE76 MT DME DMUIE76 MA Metabolism DMUIE76 RN Effect of UDP-glucuronosyltransferase (UGT) 1A polymorphism (rs8330 and rs10929303) on glucuronidation status of acetaminophen. Dose Response. 2017 Sep 11;15(3):1559325817723731. DMUIE76 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=28932176 DMUIE76 DI DMUIE76 DMUIE76 DN Acetaminophen DMUIE76 MI DESD26P DMUIE76 MN UDP-glucuronosyltransferase 1A6 (UGT1A6) DMUIE76 MT DME DMUIE76 MA Metabolism DMUIE76 RN UGT1A6 and UGT2B15 polymorphisms and acetaminophen conjugation in response to a randomized, controlled diet of select fruits and vegetables. Drug Metab Dispos. 2011 Sep;39(9):1650-7. DMUIE76 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=21666065 DMUIE76 DI DMUIE76 DMUIE76 DN Acetaminophen DMUIE76 MI DE85D2P DMUIE76 MN UDP-glucuronosyltransferase 1A9 (UGT1A9) DMUIE76 MT DME DMUIE76 MA Metabolism DMUIE76 RN Polymorphic expression of UGT1A9 is associated with variable acetaminophen glucuronidation in neonates: a population pharmacokinetic and pharmacogenetic study. Clin Pharmacokinet. 2018 Oct;57(10):1325-1336. DMUIE76 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=29654492 DMUIE76 DI DMUIE76 DMUIE76 DN Acetaminophen DMUIE76 MI DENZ6B1 DMUIE76 MN UDP-glucuronosyltransferase 2B15 (UGT2B15) DMUIE76 MT DME DMUIE76 MA Metabolism DMUIE76 RN Characterization of niflumic acid as a selective inhibitor of human liver microsomal UDP-glucuronosyltransferase 1A9: application to the reaction phenotyping of acetaminophen glucuronidation. Drug Metab Dispos. 2011 Apr;39(4):644-52. DMUIE76 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=21245288 DM1AF5U DI DM1AF5U DM1AF5U DN Acetazolamide DM1AF5U MI TTHQPL7 DM1AF5U MN Carbonic anhydrase I (CA-I) DM1AF5U MT DTT DM1AF5U MA Modulator DM1AF5U RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. DM1AF5U RU https://www.fda.gov/ DM4SJ5Y DI DM4SJ5Y DM4SJ5Y DN Acetic Acid, Glacial DM4SJ5Y MI DEVDYN7 DM4SJ5Y MN Cytochrome P450 2E1 (CYP2E1) DM4SJ5Y MT DME DM4SJ5Y MA Metabolism DM4SJ5Y RN Kinetics of cytochrome P450 2E1-catalyzed oxidation of ethanol to acetic acid via acetaldehyde. J Biol Chem. 1999 Aug 20;274(34):23833-40. DM4SJ5Y RU https://www.ncbi.nlm.nih.gov/pubmed/?term=10446146 DMR6N7H DI DMR6N7H DMR6N7H DN Acetohexamide DMR6N7H MI TTP835K DMR6N7H MN ATP-binding cassette transporter C8 (ABCC8) DMR6N7H MT DTT DMR6N7H MA Modulator DMR6N7H RN Diabetes and insulin secretion: the ATP-sensitive K+ channel (K ATP) connection.Diabetes.2005 Nov;54(11):3065-72. DMR6N7H RU https://www.ncbi.nlm.nih.gov/pubmed/16249427 DMR6N7H DI DMR6N7H DMR6N7H DN Acetohexamide DMR6N7H MI DE5IED8 DMR6N7H MN Cytochrome P450 2C9 (CYP2C9) DMR6N7H MT DME DMR6N7H MA Metabolism DMR6N7H RN Clinically and pharmacologically relevant interactions of antidiabetic drugs. Ther Adv Endocrinol Metab. 2016 Apr;7(2):69-83. DMR6N7H RU https://www.ncbi.nlm.nih.gov/pubmed/?term=27092232 DMR6N7H DI DMR6N7H DMR6N7H DN Acetohexamide DMR6N7H MI DEXPVUN DMR6N7H MN Short-chain dehydrogenase/reductase retSDR1 (DHRS3) DMR6N7H MT DME DMR6N7H MA Metabolism DMR6N7H RN Molecular and biochemical characterisation of human short-chain dehydrogenase/reductase member 3 (DHRS3). Chem Biol Interact. 2015 Jun 5;234:178-87. DMR6N7H RU https://www.ncbi.nlm.nih.gov/pubmed/?term=25451588 DMYX7NI DI DMYX7NI DMYX7NI DN Acetohydroxamic Acid DMYX7NI MI TTAS2UO DMYX7NI MN Bacterial Urease (Bact ureC) DMYX7NI MT DTT DMYX7NI MA Inhibitor DMYX7NI RN Enzymatic, immunological and phylogenetic characterization of Brucella suis urease. BMC Microbiol. 2008 Jul 19;8:121. DMYX7NI RU https://pubmed.ncbi.nlm.nih.gov/18638408 DMZV2PJ DI DMZV2PJ DMZV2PJ DN Acetophenazine DMZV2PJ MI TTEX248 DMZV2PJ MN Dopamine D2 receptor (D2R) DMZV2PJ MT DTT DMZV2PJ MA Antagonist DMZV2PJ RN Atypical antipsychotics: mechanism of action. Can J Psychiatry. 2002 Feb;47(1):27-38. DMZV2PJ RU https://pubmed.ncbi.nlm.nih.gov/11873706 DMDF79Z DI DMDF79Z DMDF79Z DN Acetylcholine DMDF79Z MI DEQ2BAJ DMDF79Z MN Acetylcholinesterase (ACHE) DMDF79Z MT DME DMDF79Z MA Metabolism DMDF79Z RN How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMDF79Z RU https://www.ncbi.nlm.nih.gov/pubmed/?term=17139284 DMDF79Z DI DMDF79Z DMDF79Z DN Acetylcholine DMDF79Z MI DT8KXR9 DMDF79Z MN Choline transporter-like protein 4 (SLC44A4) DMDF79Z MT DTP DMDF79Z MA Substrate DMDF79Z RN Choline transporter-like protein 4 (CTL4) links to non-neuronal acetylcholine synthesis. J Neurochem. 2013 Aug;126(4):451-61. DMDF79Z RU http://www.ncbi.nlm.nih.gov/pubmed/23651124 DMDF79Z DI DMDF79Z DMDF79Z DN Acetylcholine DMDF79Z MI TTOXS3C DMDF79Z MN Muscarinic acetylcholine receptor (CHRM) DMDF79Z MT DTT DMDF79Z MA Agonist DMDF79Z RN Thiochrome enhances acetylcholine affinity at muscarinic M4 receptors: receptor subtype selectivity via cooperativity rather than affinity. Mol Pharmacol. 2004 Jan;65(1):257-66. DMDF79Z RU https://pubmed.ncbi.nlm.nih.gov/14722259 DMDF79Z DI DMDF79Z DMDF79Z DN Acetylcholine DMDF79Z MI DTT79CX DMDF79Z MN Organic cation transporter 1 (SLC22A1) DMDF79Z MT DTP DMDF79Z MA Substrate DMDF79Z RN Role of acetylcholine and polyspecific cation transporters in serotonin-induced bronchoconstriction in the mouse. Respir Res. 2006 Apr 12;7:65. DMDF79Z RU http://www.ncbi.nlm.nih.gov/pubmed/16608531 DMDF79Z DI DMDF79Z DMDF79Z DN Acetylcholine DMDF79Z MI DT6201N DMDF79Z MN Organic cation transporter 3 (SLC22A3) DMDF79Z MT DTP DMDF79Z MA Substrate DMDF79Z RN Organic cation transporters: physiology, toxicology and special focus on ethidium as a novel substrate. Curr Drug Metab. 2009 Jul;10(6):617-31. DMDF79Z RU http://www.ncbi.nlm.nih.gov/pubmed/19702534 DMDF79Z DI DMDF79Z DMDF79Z DN Acetylcholine DMDF79Z MI DT3T2K0 DMDF79Z MN Vesicular acetylcholine transporter (SLC18A3) DMDF79Z MT DTP DMDF79Z MA Substrate DMDF79Z RN SLC18: Vesicular neurotransmitter transporters for monoamines and acetylcholine. Mol Aspects Med. 2013 Apr-Jun;34(2-3):360-72. DMDF79Z RU http://www.ncbi.nlm.nih.gov/pubmed/23506877 DMHAUO0 DI DMHAUO0 DMHAUO0 DN Acetyldigitoxin DMHAUO0 MI TTWK8D0 DMHAUO0 MN Sodium pump subunit alpha-1 (ATP1A1) DMHAUO0 MT DTT DMHAUO0 MA Modulator DMHAUO0 RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. DMHAUO0 RU https://www.fda.gov/ DMYLOVR DI DMYLOVR DMYLOVR DN Aciclovir DMYLOVR MI DTW7AE3 DMYLOVR MN Alanine/serine/cysteine/threonine transporter 2 (SLC1A5) DMYLOVR MT DTP DMYLOVR MA Substrate DMYLOVR RN Amino Acid Transporter ATB0,+ as a delivery system for drugs and prodrugs. Curr Drug Targets Immune Endocr Metabol Disord. 2005 Dec;5(4):357-64. DMYLOVR RU http://www.ncbi.nlm.nih.gov/pubmed/16375689 DMYLOVR DI DMYLOVR DMYLOVR DN Aciclovir DMYLOVR MI DTI7UX6 DMYLOVR MN Breast cancer resistance protein (ABCG2) DMYLOVR MT DTP DMYLOVR MA Substrate DMYLOVR RN Acyclovir is a substrate for the human breast cancer resistance protein (BCRP/ABCG2): implications for renal tubular transport and acyclovir-induced nephrotoxicity. Can J Physiol Pharmacol. 2011 Sep;89(9):675-80. DMYLOVR RU https://doi.org/10.1139/y11-045 DMYLOVR DI DMYLOVR DMYLOVR DN Aciclovir DMYLOVR MI TTIU7X1 DMYLOVR MN Herpes simplex virus DNA polymerase UL30 (HSV UL30) DMYLOVR MT DTT DMYLOVR MA Modulator DMYLOVR RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. DMYLOVR RU https://www.fda.gov/ DMYLOVR DI DMYLOVR DMYLOVR DN Aciclovir DMYLOVR MI DTZGT0P DMYLOVR MN Multidrug and toxin extrusion protein 1 (SLC47A1) DMYLOVR MT DTP DMYLOVR MA Substrate DMYLOVR RN Substrate specificity of MATE1 and MATE2-K, human multidrug and toxin extrusions/H(+)-organic cation antiporters. Biochem Pharmacol. 2007 Jul 15;74(2):359-71. DMYLOVR RU http://www.ncbi.nlm.nih.gov/pubmed/17509534 DMYLOVR DI DMYLOVR DMYLOVR DN Aciclovir DMYLOVR MI DT3TX4H DMYLOVR MN Multidrug and toxin extrusion protein 2 (SLC47A2) DMYLOVR MT DTP DMYLOVR MA Substrate DMYLOVR RN Substrate specificity of MATE1 and MATE2-K, human multidrug and toxin extrusions/H(+)-organic cation antiporters. Biochem Pharmacol. 2007 Jul 15;74(2):359-71. DMYLOVR RU http://www.ncbi.nlm.nih.gov/pubmed/17509534 DMYLOVR DI DMYLOVR DMYLOVR DN Aciclovir DMYLOVR MI DTFI42L DMYLOVR MN Multidrug resistance-associated protein 2 (ABCC2) DMYLOVR MT DTP DMYLOVR MA Substrate DMYLOVR RN Gene expression in the human intestine and correlation with oral valacyclovir pharmacokinetic parameters. J Pharmacol Exp Ther. 2003 Aug;306(2):778-86. DMYLOVR RU http://www.ncbi.nlm.nih.gov/pubmed/12750437 DMYLOVR DI DMYLOVR DMYLOVR DN Aciclovir DMYLOVR MI DTQ23VB DMYLOVR MN Organic anion transporter 1 (SLC22A6) DMYLOVR MT DTP DMYLOVR MA Substrate DMYLOVR RN Human organic anion transporters and human organic cation transporters mediate renal antiviral transport. J Pharmacol Exp Ther. 2002 Mar;300(3):918-24. DMYLOVR RU http://www.ncbi.nlm.nih.gov/pubmed/11861798 DMYLOVR DI DMYLOVR DMYLOVR DN Aciclovir DMYLOVR MI DT0OC1Q DMYLOVR MN Organic anion transporter 2 (SLC22A7) DMYLOVR MT DTP DMYLOVR MA Substrate DMYLOVR RN Organic anion transporter 2 (SLC22A7) is a facilitative transporter of cGMP. Mol Pharmacol. 2008 Apr;73(4):1151-8. DMYLOVR RU http://www.ncbi.nlm.nih.gov/pubmed/18216183 DMYLOVR DI DMYLOVR DMYLOVR DN Aciclovir DMYLOVR MI DTVP67E DMYLOVR MN Organic anion transporter 3 (SLC22A8) DMYLOVR MT DTP DMYLOVR MA Substrate DMYLOVR RN Expression of organic anion transporter 2 in the human kidney and its potential role in the tubular secretion of guanine-containing antiviral drugs. Drug Metab Dispos. 2012 Mar;40(3):617-24. DMYLOVR RU http://www.ncbi.nlm.nih.gov/pubmed/22190696 DMYLOVR DI DMYLOVR DMYLOVR DN Aciclovir DMYLOVR MI DTT79CX DMYLOVR MN Organic cation transporter 1 (SLC22A1) DMYLOVR MT DTP DMYLOVR MA Substrate DMYLOVR RN Human organic anion transporters and human organic cation transporters mediate renal antiviral transport. J Pharmacol Exp Ther. 2002 Mar;300(3):918-24. DMYLOVR RU http://www.ncbi.nlm.nih.gov/pubmed/11861798 DMYLOVR DI DMYLOVR DMYLOVR DN Aciclovir DMYLOVR MI TTHPJTK DMYLOVR MN Varicella-zoster virus DNA polymerase (VZV ORF28) DMYLOVR MT DTT DMYLOVR MA Modulator DMYLOVR RN Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41. DMYLOVR RU https://www.ncbi.nlm.nih.gov/pubmed/15950434 DM8BKU9 DI DM8BKU9 DM8BKU9 DN Acitretin DM8BKU9 MI TTH8FZW DM8BKU9 MN Signal transducer and activator of transcription 3 (STAT3) DM8BKU9 MT DTT DM8BKU9 MA Inhibitor DM8BKU9 RN Effects of acitretin on the expression of signaling pathway-related genes in epidermal squamous-cell carcinoma cells. Zhonghua Zhong Liu Za Zhi. 2006 Jan;28(1):21-4. DM8BKU9 RU https://pubmed.ncbi.nlm.nih.gov/16737614 DMLFZHD DI DMLFZHD DMLFZHD DN Aclarubicin DMLFZHD MI TT0IHXV DMLFZHD MN DNA topoisomerase II (TOP2) DMLFZHD MT DTT DMLFZHD MA Inhibitor DMLFZHD RN Linker length in podophyllotoxin-acridine conjugates determines potency in vivo and in vitro as well as specificity against MDR cell lines. Anticancer Drug Des. 2001 Dec;16(6):305-15. DMLFZHD RU https://pubmed.ncbi.nlm.nih.gov/12375883 DM7JT24 DI DM7JT24 DM7JT24 DN Acocantherin DM7JT24 MI DTE2B1D DM7JT24 MN Organic anion transporting polypeptide 1A2 (SLCO1A2) DM7JT24 MT DTP DM7JT24 MA Substrate DM7JT24 RN Molecular cloning and functional characterization of the mouse organic-anion-transporting polypeptide 1 (Oatp1) and mapping of the gene to chromosome X. Biochem J. 2000 Jan 1;345 Pt 1:115-20. DM7JT24 RU http://www.ncbi.nlm.nih.gov/pubmed/10600646 DM7JT24 DI DM7JT24 DM7JT24 DN Acocantherin DM7JT24 MI DT3D8F0 DM7JT24 MN Organic anion transporting polypeptide 1B1 (SLCO1B1) DM7JT24 MT DTP DM7JT24 MA Substrate DM7JT24 RN Regulation of Organic Anion Transporting Polypeptides (OATP) 1B1- and OATP1B3-Mediated Transport: An Updated Review in the Context of OATP-Mediated Drug-Drug Interactions. Int J Mol Sci. 2018 Mar 14;19(3). pii: E855. DM7JT24 RU http://www.ncbi.nlm.nih.gov/pubmed/29538325 DM7JT24 DI DM7JT24 DM7JT24 DN Acocantherin DM7JT24 MI DT9C1TS DM7JT24 MN Organic anion transporting polypeptide 1B3 (SLCO1B3) DM7JT24 MT DTP DM7JT24 MA Substrate DM7JT24 RN Organic anion-transporting polypeptide B (OATP-B) and its functional comparison with three other OATPs of human liver. Gastroenterology. 2001 Feb;120(2):525-33. DM7JT24 RU http://www.ncbi.nlm.nih.gov/pubmed/11159893 DM7JT24 DI DM7JT24 DM7JT24 DN Acocantherin DM7JT24 MI DTY0QMU DM7JT24 MN Organic anion transporting polypeptide 4C1 (SLCO4C1) DM7JT24 MT DTP DM7JT24 MA Substrate DM7JT24 RN Isolation and characterization of a digoxin transporter and its rat homologue expressed in the kidney. Proc Natl Acad Sci U S A. 2004 Mar 9;101(10):3569-74. DM7JT24 RU http://www.ncbi.nlm.nih.gov/pubmed/14993604 DM7JT24 DI DM7JT24 DM7JT24 DN Acocantherin DM7JT24 MI TTWK8D0 DM7JT24 MN Sodium pump subunit alpha-1 (ATP1A1) DM7JT24 MT DTT DM7JT24 MA Binder DM7JT24 RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DM7JT24 RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMTIGA0 DI DMTIGA0 DMTIGA0 DN Acrivastine DMTIGA0 MI TTTIBOJ DMTIGA0 MN Histamine H1 receptor (H1R) DMTIGA0 MT DTT DMTIGA0 MA Antagonist DMTIGA0 RN Clinical pharmacology of new histamine H1 receptor antagonists. Clin Pharmacokinet. 1999 May;36(5):329-52. DMTIGA0 RU https://pubmed.ncbi.nlm.nih.gov/10384858 DMTIGA0 DI DMTIGA0 DMTIGA0 DN Acrivastine DMTIGA0 MI DTUGYRD DMTIGA0 MN P-glycoprotein 1 (ABCB1) DMTIGA0 MT DTP DMTIGA0 MA Substrate DMTIGA0 RN Passive permeability and P-glycoprotein-mediated efflux differentiate central nervous system (CNS) and non-CNS marketed drugs. J Pharmacol Exp Ther. 2002 Dec;303(3):1029-37. DMTIGA0 RU http://www.ncbi.nlm.nih.gov/pubmed/12438524 DMQMV1B DI DMQMV1B DMQMV1B DN Adalimumab DMQMV1B MI TTF8CQI DMQMV1B MN Tumor necrosis factor (TNF) DMQMV1B MT DTT DMQMV1B RN Adalimumab for psoriasis patients who are non-responders to etanercept: open-label prospective evaluation. J Eur Acad Dermatol Venereol. 2009 Dec;23(12):1394-7. DMQMV1B RU https://pubmed.ncbi.nlm.nih.gov/19573024 DMX2358 DI DMX2358 DMX2358 DN Adapalene DMX2358 MI TTOD7B3 DMX2358 MN Retinoic acid receptor (RAR) DMX2358 MT DTT DMX2358 MA Binder DMX2358 RN A review of adapalene in the treatment of acne vulgaris. J Adolesc Health. 2008 Nov;43(5):421-4. DMX2358 RU https://pubmed.ncbi.nlm.nih.gov/18848668 DMM278X DI DMM278X DMM278X DN Adefovir DMM278X MI DTI7UX6 DMM278X MN Breast cancer resistance protein (ABCG2) DMM278X MT DTP DMM278X MA Substrate DMM278X RN ABC transporters and their role in nucleoside and nucleotide drug resistance. Biochem Pharmacol. 2012 Apr 15;83(8):1073-83. DMM278X RU https://doi.org/10.1016/j.bcp.2011.12.042 DMM278X DI DMM278X DMM278X DN Adefovir DMM278X MI DTSYQGK DMM278X MN Multidrug resistance-associated protein 1 (ABCC1) DMM278X MT DTP DMM278X MA Substrate DMM278X RN Human intestinal transporter database: QSAR modeling and virtual profiling of drug uptake, efflux and interactions. Pharm Res. 2013 Apr;30(4):996-1007. DMM278X RU https://doi.org/10.1007/s11095-012-0935-x DMM278X DI DMM278X DMM278X DN Adefovir DMM278X MI DTFI42L DMM278X MN Multidrug resistance-associated protein 2 (ABCC2) DMM278X MT DTP DMM278X MA Substrate DMM278X RN Pharmacogenetics of membrane transporters: an update on current approaches. Mol Biotechnol. 2010 Feb;44(2):152-67. DMM278X RU https://doi.org/10.1007/s12033-009-9220-6 DMM278X DI DMM278X DMM278X DN Adefovir DMM278X MI DTCSGPB DMM278X MN Multidrug resistance-associated protein 4 (ABCC4) DMM278X MT DTP DMM278X MA Substrate DMM278X RN Functional involvement of multidrug resistance-associated protein 4 (MRP4/ABCC4) in the renal elimination of the antiviral drugs adefovir and tenofovir. Mol Pharmacol. 2007 Feb;71(2):619-27. DMM278X RU http://www.ncbi.nlm.nih.gov/pubmed/17110501 DMM278X DI DMM278X DMM278X DN Adefovir DMM278X MI DTQ23VB DMM278X MN Organic anion transporter 1 (SLC22A6) DMM278X MT DTP DMM278X MA Substrate DMM278X RN Cytotoxicity of antiviral nucleotides adefovir and cidofovir is induced by the expression of human renal organic anion transporter 1. J Am Soc Nephrol. 2000 Mar;11(3):383-93. DMM278X RU http://www.ncbi.nlm.nih.gov/pubmed/10703662 DMM278X DI DMM278X DMM278X DN Adefovir DMM278X MI DTVP67E DMM278X MN Organic anion transporter 3 (SLC22A8) DMM278X MT DTP DMM278X MA Substrate DMM278X RN FDA Drug Development and Drug Interactions DMM278X RU https://www.fda.gov/drugs/developmentapprovalprocess/developmentresources/druginteractionslabeling/ucm093664.htm#table3-2 DMMAWY1 DI DMMAWY1 DMMAWY1 DN Adefovir dipivoxil DMMAWY1 MI DEY1FJO DMMAWY1 MN ATP-AMP transphosphorylase 2 (AK2) DMMAWY1 MT DME DMMAWY1 MA Metabolism DMMAWY1 RN Scientific discussion of Hepsera. DMMAWY1 RU https://www.ema.europa.eu/en/documents/scientific-discussion/hepsera-epar-scientific-discussion_en.pdf DMMAWY1 DI DMMAWY1 DMMAWY1 DN Adefovir dipivoxil DMMAWY1 MI TT84ETX DMMAWY1 MN Human immunodeficiency virus Reverse transcriptase (HIV RT) DMMAWY1 MT DTT DMMAWY1 MA Modulator DMMAWY1 RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. DMMAWY1 RU https://www.fda.gov/ DMYQDBO DI DMYQDBO DMYQDBO DN Ademetionine DMYQDBO MI DEVDYN7 DMYQDBO MN Cytochrome P450 2E1 (CYP2E1) DMYQDBO MT DME DMYQDBO MA Metabolism DMYQDBO RN Inhibition of CYP2E1 catalytic activity in vitro by S-adenosyl-L-methionine. Biochem Pharmacol. 2005 Apr 1;69(7):1081-93. DMYQDBO RU https://www.ncbi.nlm.nih.gov/pubmed/?term=15763544 DMYQDBO DI DMYQDBO DMYQDBO DN Ademetionine DMYQDBO MI DEFQ8VO DMYQDBO MN Thiopurine methyltransferase (TPMT) DMYQDBO MT DME DMYQDBO MA Metabolism DMYQDBO RN Evolution of putrescine N-methyltransferase from spermidine synthase demanded alterations in substrate binding. FEBS Lett. 2009 Oct 20;583(20):3367-74. DMYQDBO RU https://www.ncbi.nlm.nih.gov/pubmed/?term=19796640 DMYQDBO DI DMYQDBO DMYQDBO DN Ademetionine DMYQDBO MI TTX2N1T DMYQDBO MN Transferase unspecific (TF) DMYQDBO MT DTT DMYQDBO MA Modulator DMYQDBO RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health Human Services. 2013 DMYQDBO RU https://www.accessdata.fda.gov/drugsatfda_docs/nda/2013/205123Orig1s000MedR.pdf DMZLHKJ DI DMZLHKJ DMZLHKJ DN Adenine DMZLHKJ MI DTLMGFJ DMZLHKJ MN Adenine nucleotide translocator 3 (SLC25A6) DMZLHKJ MT DTP DMZLHKJ MA Substrate DMZLHKJ RN Adenine nucleotide (ADP/ATP) translocase 3 participates in the tumor necrosis factor induced apoptosis of MCF-7 cells. Mol Biol Cell. 2007 Nov;18(11):4681-9. DMZLHKJ RU http://www.ncbi.nlm.nih.gov/pubmed/17855512 DMZLHKJ DI DMZLHKJ DMZLHKJ DN Adenine DMZLHKJ MI TTUTN1I DMZLHKJ MN Human Deoxyribonucleic acid (hDNA) DMZLHKJ MT DTT DMZLHKJ MA Binder DMZLHKJ RN Escherichia coli DNA adenine methyltransferase: intrasite processivity and substrate-induced dimerization and activation. Biochemistry. 2009 Aug 11;48(31):7399-410. DMZLHKJ RU https://pubmed.ncbi.nlm.nih.gov/19580332 DMM2NSK DI DMM2NSK DMM2NSK DN Adenosine DMM2NSK MI TTNE7KG DMM2NSK MN Adenosine A2b receptor (ADORA2B) DMM2NSK MT DTT DMM2NSK MA Modulator DMM2NSK RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. DMM2NSK RU https://www.fda.gov/ DMM2NSK DI DMM2NSK DMM2NSK DN Adenosine DMM2NSK MI DEDQHBV DMM2NSK MN Adenosine aminohydrolase (ADA) DMM2NSK MT DME DMM2NSK MA Metabolism DMM2NSK RN A functional genetic variation of adenosine deaminase affects the duration and intensity of deep sleep in humans. Proc Natl Acad Sci U S A. 2005 Oct 25;102(43):15676-81. DMM2NSK RU https://www.ncbi.nlm.nih.gov/pubmed/?term=16221767 DMM2NSK DI DMM2NSK DMM2NSK DN Adenosine DMM2NSK MI DTXD1TQ DMM2NSK MN Equilibrative nucleoside transporter 1 (SLC29A1) DMM2NSK MT DTP DMM2NSK MA Substrate DMM2NSK RN Nitric oxide reduces adenosine transporter ENT1 gene (SLC29A1) promoter activity in human fetal endothelium from gestational diabetes. J Cell Physiol. 2006 Aug;208(2):451-60. DMM2NSK RU http://www.ncbi.nlm.nih.gov/pubmed/16688763 DMM2NSK DI DMM2NSK DMM2NSK DN Adenosine DMM2NSK MI DTYVM24 DMM2NSK MN Multidrug resistance-associated protein 5 (ABCC5) DMM2NSK MT DTP DMM2NSK MA Substrate DMM2NSK RN Role of MRP4 and MRP5 in biology and chemotherapy. AAPS PharmSci. 2002;4(3):E14. DMM2NSK RU http://www.ncbi.nlm.nih.gov/pubmed/12423063 DMM2NSK DI DMM2NSK DMM2NSK DN Adenosine DMM2NSK MI DEYWLRK DMM2NSK MN Sulfotransferase 1A1 (SULT1A1) DMM2NSK MT DME DMM2NSK MA Metabolism DMM2NSK RN Regulation of sulfate assimilation in plants: 7. Cysteine inactivation of adenosine 5'-phosphosulfate sulfotransferase in Lemna minor L. Plant Physiol. 1978 Mar;61(3):342-7. DMM2NSK RU https://www.ncbi.nlm.nih.gov/pubmed/?term=16660289 DMNIJT0 DI DMNIJT0 DMNIJT0 DN Adenosine monophosphate DMNIJT0 MI DE2MV1R DMNIJT0 MN Adenine phosphoribosyltransferase (APRT) DMNIJT0 MT DME DMNIJT0 MA Metabolism DMNIJT0 RN Configuration of a scintillation proximity assay for the activity assessment of recombinant human adenine phosphoribosyltransferase. Assay Drug Dev Technol. 2006 Dec;4(6):661-9. DMNIJT0 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=17199504 DMNIJT0 DI DMNIJT0 DMNIJT0 DN Adenosine monophosphate DMNIJT0 MI TTV1ZSQ DMNIJT0 MN Adenylate cyclase type 1 (ADCY1) DMNIJT0 MT DTT DMNIJT0 MA Binder DMNIJT0 RN Ecto- and cytosolic 5'-nucleotidases in normal and AMP deaminase-deficient human skeletal muscle. Biol Chem. 2006 Jan;387(1):53-8. DMNIJT0 RU https://pubmed.ncbi.nlm.nih.gov/16497164 DMNIJT0 DI DMNIJT0 DMNIJT0 DN Adenosine monophosphate DMNIJT0 MI DTYR5U7 DMNIJT0 MN Peroxisomal membrane protein PMP34 (SLC25A17) DMNIJT0 MT DTP DMNIJT0 MA Substrate DMNIJT0 RN The human gene SLC25A17 encodes a peroxisomal transporter of coenzyme A, FAD and NAD+. Biochem J. 2012 Apr 1;443(1):241-7. DMNIJT0 RU http://www.ncbi.nlm.nih.gov/pubmed/22185573 DM79F6G DI DM79F6G DM79F6G DN Adenosine triphosphate DM79F6G MI TT3PJMV DM79F6G MN Tyrosine-protein kinase ABL1 (ABL) DM79F6G MT DTT DM79F6G MA Inhibitor DM79F6G RN Targeted chronic myeloid leukemia therapy: Seeking a cure. Am J Health Syst Pharm. 2007 Dec 15;64(24 Suppl 15):S9-15. DM79F6G RU https://pubmed.ncbi.nlm.nih.gov/18056932 DMBHO9Y DI DMBHO9Y DMBHO9Y DN Adinazolam DMBHO9Y MI DE4LYSA DMBHO9Y MN Cytochrome P450 3A4 (CYP3A4) DMBHO9Y MT DME DMBHO9Y MA Metabolism DMBHO9Y RN Kinetic characterization and identification of the enzymes responsible for the hepatic biotransformation of adinazolam and N-desmethyladinazolam in man. J Pharm Pharmacol. 1998 Mar;50(3):265-74. DMBHO9Y RU https://www.ncbi.nlm.nih.gov/pubmed/?term=9600717 DMBHO9Y DI DMBHO9Y DMBHO9Y DN Adinazolam DMBHO9Y MI DEGTFWK DMBHO9Y MN Mephenytoin 4-hydroxylase (CYP2C19) DMBHO9Y MT DME DMBHO9Y MA Metabolism DMBHO9Y RN Kinetic characterization and identification of the enzymes responsible for the hepatic biotransformation of adinazolam and N-desmethyladinazolam in man. J Pharm Pharmacol. 1998 Mar;50(3):265-74. DMBHO9Y RU https://www.ncbi.nlm.nih.gov/pubmed/?term=9600717 DMBHO9Y DI DMBHO9Y DMBHO9Y DN Adinazolam DMBHO9Y MI TTPTXIN DMBHO9Y MN Translocator protein (TSPO) DMBHO9Y MT DTT DMBHO9Y MA Agonist DMBHO9Y RN Effects of antidepressants and benzodiazepine treatments on the dendritic structure of CA3 pyramidal neurons after chronic stress. Eur J Pharmacol. 1999 Apr 29;371(2-3):113-22. DMBHO9Y RU https://pubmed.ncbi.nlm.nih.gov/10357248 DMVWHTG DI DMVWHTG DMVWHTG DN Afamelanotide DMVWHTG MI TT0MV2T DMVWHTG MN Melanocortin receptor 1 (MC1R) DMVWHTG MT DTT DMVWHTG MA Modulator DMVWHTG RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health Human Services. 2019 DMVWHTG RU https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/210797s000lbl.pdf DMT3D5I DI DMT3D5I DMT3D5I DN Aflibercept DMT3D5I MI TT48I1Y DMT3D5I MN Placenta growth factor (PlGF) DMT3D5I MT DTT DMT3D5I MA Modulator DMT3D5I RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015 DMT3D5I RU https://www.accessdata.fda.gov/scripts/cder/drugsatfda/ DMT3D5I DI DMT3D5I DMT3D5I DN Aflibercept DMT3D5I MI TTOHSBA DMT3D5I MN Vascular endothelial growth factor A (VEGFA) DMT3D5I MT DTT DMT3D5I MA Modulator DMT3D5I RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015 DMT3D5I RU https://www.accessdata.fda.gov/scripts/cder/drugsatfda/ DMT3D5I DI DMT3D5I DMT3D5I DN Aflibercept DMT3D5I MI TTPJQHE DMT3D5I MN Vascular endothelial growth factor B (VEGFB) DMT3D5I MT DTT DMT3D5I MA Modulator DMT3D5I RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015 DMT3D5I RU https://www.accessdata.fda.gov/scripts/cder/drugsatfda/ DMPOD47 DI DMPOD47 DMPOD47 DN Ajmalicine DMPOD47 MI TTR6W5O DMPOD47 MN Adrenergic receptor beta-1 (ADRB1) DMPOD47 MT DTT DMPOD47 MA Modulator DMPOD47 RN Medicinal plants in therapy. Bull World Health Organ. 1985;63(6):965-81. DMPOD47 RU https://pubmed.ncbi.nlm.nih.gov/3879679 DMDJW5K DI DMDJW5K DMDJW5K DN Ajmaline DMDJW5K MI DECB0K3 DMDJW5K MN Cytochrome P450 2D6 (CYP2D6) DMDJW5K MT DME DMDJW5K MA Metabolism DMDJW5K RN Summary of information on human CYP enzymes: human P450 metabolism data. Drug Metab Rev. 2002 Feb-May;34(1-2):83-448. DMDJW5K RU https://www.ncbi.nlm.nih.gov/pubmed/?term=11996015 DMDJW5K DI DMDJW5K DMDJW5K DN Ajmaline DMDJW5K MI DTUGYRD DMDJW5K MN P-glycoprotein 1 (ABCB1) DMDJW5K MT DTP DMDJW5K MA Substrate DMDJW5K RN ATP-dependent transport of amphiphilic cations across the hepatocyte canalicular membrane mediated by mdr1 P-glycoprotein. FEBS Lett. 1994 Apr 25;343(2):168-72. DMDJW5K RU http://www.ncbi.nlm.nih.gov/pubmed/7909523 DML6SRO DI DML6SRO DML6SRO DN Alacepril DML6SRO MI TTL69WB DML6SRO MN Angiotensin-converting enzyme (ACE) DML6SRO MT DTT DML6SRO MA Modulator DML6SRO RN Natural products as sources of new drugs over the last 25 years. J Nat Prod. 2007 Mar;70(3):461-77. DML6SRO RU https://pubmed.ncbi.nlm.nih.gov/17309302 DMYZ57N DI DMYZ57N DMYZ57N DN Albendazole DMYZ57N MI DEJGDUW DMYZ57N MN Cytochrome P450 1A2 (CYP1A2) DMYZ57N MT DME DMYZ57N MA Metabolism DMYZ57N RN Cytochrome P450 1A1/2 induction by antiparasitic drugs: dose-dependent increase in ethoxyresorufin O-deethylase activity and mRNA caused by quinine, primaquine and albendazole in HepG2 cells. Eur J Clin Pharmacol. 2002 Nov;58(8):537-42. DMYZ57N RU https://www.ncbi.nlm.nih.gov/pubmed/?term=12451431 DMYZ57N DI DMYZ57N DMYZ57N DN Albendazole DMYZ57N MI DE4LYSA DMYZ57N MN Cytochrome P450 3A4 (CYP3A4) DMYZ57N MT DME DMYZ57N MA Metabolism DMYZ57N RN Identification of human cytochrome P(450)s that metabolise anti-parasitic drugs and predictions of in vivo drug hepatic clearance from in vitro data. Eur J Clin Pharmacol. 2003 Sep;59(5-6):429-42. DMYZ57N RU https://www.ncbi.nlm.nih.gov/pubmed/?term=12920490 DMYZ57N DI DMYZ57N DMYZ57N DN Albendazole DMYZ57N MI DEGTFWK DMYZ57N MN Mephenytoin 4-hydroxylase (CYP2C19) DMYZ57N MT DME DMYZ57N MA Metabolism DMYZ57N RN Danazol inhibits cytochrome P450 2J2 activity in a substrate-independent manner. Drug Metab Dispos. 2015 Aug;43(8):1250-3. DMYZ57N RU https://www.ncbi.nlm.nih.gov/pubmed/?term=26048912 DMYZ57N DI DMYZ57N DMYZ57N DN Albendazole DMYZ57N MI DTUGYRD DMYZ57N MN P-glycoprotein 1 (ABCB1) DMYZ57N MT DTP DMYZ57N MA Substrate DMYZ57N RN The anthelminthic agent albendazole does not interact with p-glycoprotein. Drug Metab Dispos. 2002 Apr;30(4):365-9. DMYZ57N RU http://www.ncbi.nlm.nih.gov/pubmed/11901088 DMYZ57N DI DMYZ57N DMYZ57N DN Albendazole DMYZ57N MI TTYFKSZ DMYZ57N MN Tubulin beta (TUBB) DMYZ57N MT DTT DMYZ57N MA Binder DMYZ57N RN Flubendazole interferes with a wide spectrum of cell homeostatic mechanisms in Echinococcus granulosus protoscoleces. Parasitol Int. 2009 Sep;58(3):270-7. DMYZ57N RU https://pubmed.ncbi.nlm.nih.gov/19336257 DM1JEGF DI DM1JEGF DM1JEGF DN Albiglutide DM1JEGF MI TTVIMDE DM1JEGF MN Glucagon-like peptide 1 receptor (GLP1R) DM1JEGF MT DTT DM1JEGF MA Modulator DM1JEGF RN GLP-1 receptor agonists for individualized treatment of type 2 diabetes mellitus.Nat Rev Endocrinol.2012 Dec;8(12):728-42. DM1JEGF RU https://www.ncbi.nlm.nih.gov/pubmed/22945360 DM5JTPU DI DM5JTPU DM5JTPU DN Albumin Human DM5JTPU MI TTFNGC9 DM5JTPU MN Serum albumin (ALB) DM5JTPU MT DTT DM5JTPU MA Modulator DM5JTPU RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. DM5JTPU RU https://www.fda.gov/ DM5J1NH DI DM5J1NH DM5J1NH DN Alcaftadine DM5J1NH MI TTTIBOJ DM5J1NH MN Histamine H1 receptor (H1R) DM5J1NH MT DTT DM5J1NH MA Antagonist DM5J1NH RN Mullard A: 2010 FDA drug approvals. Nat Rev Drug Discov. 2011 Feb;10(2):82-5. DM5J1NH RU https://pubmed.ncbi.nlm.nih.gov/21283092 DMAE84F DI DMAE84F DMAE84F DN Alclometasone DMAE84F MI TTJL8VG DMAE84F MN Corticosteroid-binding globulin (SERPINA6) DMAE84F MT DTT DMAE84F MA Binder DMAE84F RN The anti-inflammatory effects of LY178002 and LY256548. Agents Actions. 1989 Jun;27(3-4):300-2. DMAE84F RU https://pubmed.ncbi.nlm.nih.gov/2508442 DMAE84F DI DMAE84F DMAE84F DN Alclometasone DMAE84F MI DE4LYSA DMAE84F MN Cytochrome P450 3A4 (CYP3A4) DMAE84F MT DME DMAE84F MA Metabolism DMAE84F RN Prediction of cytochrome P450 isoform responsible for metabolizing a drug molecule. BMC Pharmacol. 2010 Jul 16;10:8. DMAE84F RU https://www.ncbi.nlm.nih.gov/pubmed/?term=20637097 DM2U4XQ DI DM2U4XQ DM2U4XQ DN ALCURONIUM DM2U4XQ MI TTLA931 DM2U4XQ MN Neuronal acetylcholine receptor alpha-7 (CHRNA7) DM2U4XQ MT DTT DM2U4XQ MA Inhibitor DM2U4XQ RN Pharmacological characteristics and binding modes of caracurine V analogues and related compounds at the neuronal alpha7 nicotinic acetylcholine re... J Med Chem. 2007 Sep 20;50(19):4616-29. DM2U4XQ RU https://pubmed.ncbi.nlm.nih.gov/17722904 DM4YMIS DI DM4YMIS DM4YMIS DN Aldesleukin DM4YMIS MI TTF89GD DM4YMIS MN Interleukin-2 (IL2) DM4YMIS MT DTT DM4YMIS MA Modulator DM4YMIS RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. DM4YMIS RU https://www.fda.gov/ DM9S2JW DI DM9S2JW DM9S2JW DN Aldosterone DM9S2JW MI DE6TYUK DM9S2JW MN Aldosterone synthase (CYP11B2) DM9S2JW MT DME DM9S2JW MA Metabolism DM9S2JW RN Heteroaryl-substituted naphthalenes and structurally modified derivatives: selective inhibitors of CYP11B2 for the treatment of congestive heart failure and myocardial fibrosis. J Med Chem. 2005 Oct 20;48(21):6632-42. DM9S2JW RU https://www.ncbi.nlm.nih.gov/pubmed/?term=16220979 DM9S2JW DI DM9S2JW DM9S2JW DN Aldosterone DM9S2JW MI DE4LYSA DM9S2JW MN Cytochrome P450 3A4 (CYP3A4) DM9S2JW MT DME DM9S2JW MA Metabolism DM9S2JW RN Aldosterone receptor antagonists: effective but often forgotten. Circulation. 2010 Feb 23;121(7):934-9. DM9S2JW RU https://www.ncbi.nlm.nih.gov/pubmed/?term=20177008 DM9S2JW DI DM9S2JW DM9S2JW DN Aldosterone DM9S2JW MI DEIBDNY DM9S2JW MN Cytochrome P450 3A5 (CYP3A5) DM9S2JW MT DME DM9S2JW MA Metabolism DM9S2JW RN CYP3A5 genotype is associated with elevated blood pressure. Pharmacogenet Genomics. 2005 Oct;15(10):737-41. DM9S2JW RU https://www.ncbi.nlm.nih.gov/pubmed/?term=16141800 DM9S2JW DI DM9S2JW DM9S2JW DN Aldosterone DM9S2JW MI TT26PHO DM9S2JW MN Mineralocorticoid receptor (MR) DM9S2JW MT DTT DM9S2JW MA Agonist DM9S2JW RN Stimulation of testosterone production in rat Leydig cells by aldosterone is mineralocorticoid receptor mediated. Mol Cell Endocrinol. 2005 Nov 24;243(1-2):35-42. DM9S2JW RU https://pubmed.ncbi.nlm.nih.gov/16188378 DM9S2JW DI DM9S2JW DM9S2JW DN Aldosterone DM9S2JW MI DTUGYRD DM9S2JW MN P-glycoprotein 1 (ABCB1) DM9S2JW MT DTP DM9S2JW MA Substrate DM9S2JW RN MDR1 genotype-dependent regulation of the aldosterone system in humans. Pharmacogenet Genomics. 2007 Feb;17(2):137-44. DM9S2JW RU http://www.ncbi.nlm.nih.gov/pubmed/17301693 DM9S2JW DI DM9S2JW DM9S2JW DN Aldosterone DM9S2JW MI TTS087L DM9S2JW MN Solute carrier family 12 member 1 (SLC12A1) DM9S2JW MT DTT DM9S2JW MA Blocker DM9S2JW RN Nongenomic effect of aldosterone on ion transport pathways of red blood cells. Cell Physiol Biochem. 2008;22(1-4):269-78. DM9S2JW RU https://pubmed.ncbi.nlm.nih.gov/18769054 DM9S2JW DI DM9S2JW DM9S2JW DN Aldosterone DM9S2JW MI DEPE0RD DM9S2JW MN Steroid 11-beta-hydroxylase (CYP11B1) DM9S2JW MT DME DM9S2JW MA Metabolism DM9S2JW RN Quantitative assessment of CYP11B1 and CYP11B2 expression in aldosterone-producing adenomas. Eur J Endocrinol. 2002 Dec;147(6):795-802. DM9S2JW RU https://www.ncbi.nlm.nih.gov/pubmed/?term=12457455 DM9S2JW DI DM9S2JW DM9S2JW DN Aldosterone DM9S2JW MI DEB3CV1 DM9S2JW MN UDP-glucuronosyltransferase 2B7 (UGT2B7) DM9S2JW MT DME DM9S2JW MA Metabolism DM9S2JW RN Human uridine diphosphate-glucuronosyltransferase UGT2B7 conjugates mineralocorticoid and glucocorticoid metabolites. Endocrinology. 2003 Jun;144(6):2659-68. DM9S2JW RU https://www.ncbi.nlm.nih.gov/pubmed/?term=12746330 DMP1I6Y DI DMP1I6Y DMP1I6Y DN Alectinib DMP1I6Y MI TTPMQSO DMP1I6Y MN ALK tyrosine kinase receptor (ALK) DMP1I6Y MT DTT DMP1I6Y MA Inhibitor DMP1I6Y RN CH5424802, a selective ALK inhibitor capable of blocking the resistant gatekeeper mutant. Cancer Cell. 2011 May 17;19(5):679-90. DMP1I6Y RU https://pubmed.ncbi.nlm.nih.gov/21575866 DMP1I6Y DI DMP1I6Y DMP1I6Y DN Alectinib DMP1I6Y MI DE4LYSA DMP1I6Y MN Cytochrome P450 3A4 (CYP3A4) DMP1I6Y MT DME DMP1I6Y MA Metabolism DMP1I6Y RN In vitro metabolism of alectinib, a novel potent ALK inhibitor, in human: contribution of CYP3A enzymes. Xenobiotica. 2018 Jun;48(6):546-554. DMP1I6Y RU https://www.ncbi.nlm.nih.gov/pubmed/?term=28657423 DMMYPWO DI DMMYPWO DMMYPWO DN Alefacept DMMYPWO MI TT5KSBY DMMYPWO MN Surface glycoprotein LFA-3 (CD58) DMMYPWO MT DTT DMMYPWO MA Modulator DMMYPWO RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. DMMYPWO RU https://www.fda.gov/ DMZL3IV DI DMZL3IV DMZL3IV DN Alemtuzumab DMZL3IV MI TTQT5S9 DMZL3IV MN Cambridge pathology 1 antigen (CD52) DMZL3IV MT DTT DMZL3IV RN Identifying alemtuzumab as an anti-myeloid cell antiangiogenic therapy for the treatment of ovarian cancer. J Transl Med. 2009 Jun 19;7:49. DMZL3IV RU https://pubmed.ncbi.nlm.nih.gov/19545375 DMY2KX9 DI DMY2KX9 DMY2KX9 DN Alendronate DMY2KX9 MI TTIKWV4 DMY2KX9 MN Geranyltranstransferase (FDPS) DMY2KX9 MT DTT DMY2KX9 MA Modulator DMY2KX9 RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. DMY2KX9 RU https://www.fda.gov/ DMCKPUR DI DMCKPUR DMCKPUR DN Alfaferone DMCKPUR MI TT95SOA DMCKPUR MN Interferon alpha (IFNA) DMCKPUR MT DTT DMCKPUR MA Modulator DMCKPUR RN Natural leukocyte interferon alpha (Alfaferone) combined with ribavirin in the treatment of patients with HCV-related cirrhosis: our experience. Infection. 2011 Oct;39(5):433-7. DMCKPUR RU https://pubmed.ncbi.nlm.nih.gov/21739360 DMVO0UB DI DMVO0UB DMVO0UB DN Alfentanil DMVO0UB MI DE4LYSA DMVO0UB MN Cytochrome P450 3A4 (CYP3A4) DMVO0UB MT DME DMVO0UB MA Metabolism DMVO0UB RN Pharmacogenetic determinants of human liver microsomal alfentanil metabolism and the role of cytochrome P450 3A5. Anesthesiology. 2005 Mar;102(3):550-6. DMVO0UB RU https://www.ncbi.nlm.nih.gov/pubmed/?term=15731592 DMVO0UB DI DMVO0UB DMVO0UB DN Alfentanil DMVO0UB MI DEIBDNY DMVO0UB MN Cytochrome P450 3A5 (CYP3A5) DMVO0UB MT DME DMVO0UB MA Metabolism DMVO0UB RN Influence of CYP3A5 genotype on the pharmacokinetics and pharmacodynamics of the cytochrome P4503A probes alfentanil and midazolam. Clin Pharmacol Ther. 2007 Oct;82(4):410-26. DMVO0UB RU https://www.ncbi.nlm.nih.gov/pubmed/?term=17554244 DMVO0UB DI DMVO0UB DMVO0UB DN Alfentanil DMVO0UB MI DERD86B DMVO0UB MN Cytochrome P450 3A7 (CYP3A7) DMVO0UB MT DME DMVO0UB MA Metabolism DMVO0UB RN Drug Interactions Flockhart Table DMVO0UB RU https://drug-interactions.medicine.iu.edu/Main-Table.aspx DMVO0UB DI DMVO0UB DMVO0UB DN Alfentanil DMVO0UB MI TTKWM86 DMVO0UB MN Opioid receptor mu (MOP) DMVO0UB MT DTT DMVO0UB MA Agonist DMVO0UB RN Concentration-effect relationship of intravenous alfentanil and ketamine on peripheral neurosensory thresholds, allodynia and hyperalgesia of neuropathic pain. Pain. 2001 Mar;91(1-2):177-87. DMVO0UB RU https://pubmed.ncbi.nlm.nih.gov/11240090 DMZVMKF DI DMZVMKF DMZVMKF DN Alfuzosin DMZVMKF MI TT34BHT DMZVMKF MN Adrenergic receptor alpha-1D (ADRA1D) DMZVMKF MT DTT DMZVMKF MA Antagonist DMZVMKF RN Alfuzosin: a review of the therapeutic use of the prolonged-release formulation given once daily in the management of benign prostatic hyperplasia. Drugs. 2002;62(4):633-53. DMZVMKF RU https://pubmed.ncbi.nlm.nih.gov/11893233 DMZVMKF DI DMZVMKF DMZVMKF DN Alfuzosin DMZVMKF MI DTI7UX6 DMZVMKF MN Breast cancer resistance protein (ABCG2) DMZVMKF MT DTP DMZVMKF MA Substrate DMZVMKF RN In vitro and in vivo evidence for the importance of breast cancer resistance protein transporters (BCRP/MXR/ABCP/ABCG2). Handb Exp Pharmacol. 2011;(201):325-71. DMZVMKF RU https://doi.org/10.1007/978-3-642-14541-4_9 DM4LOD0 DI DM4LOD0 DM4LOD0 DN Alglucosidase alfa DM4LOD0 MI TT95ICL DM4LOD0 MN Mannose-6-phosphate receptor (M6PR) DM4LOD0 MT DTT DM4LOD0 MA Binder DM4LOD0 RN Early treatment with alglucosidase alpha prolongs long-term survival of infants with Pompe disease. Pediatr Res. 2009 Sep;66(3):329-35. DM4LOD0 RU https://pubmed.ncbi.nlm.nih.gov/19542901 DM1BV7W DI DM1BV7W DM1BV7W DN Aliskiren DM1BV7W MI TTB2MXP DM1BV7W MN Angiotensinogenase renin (REN) DM1BV7W MT DTT DM1BV7W MA Inhibitor DM1BV7W RN Comparative effects of aliskiren-based and ramipril-based therapy on the renin system during long-term (6 months) treatment and withdrawal in patie... J Renin Angiotensin Aldosterone Syst. 2009 Sep;10(3):157-67. DM1BV7W RU https://pubmed.ncbi.nlm.nih.gov/19617271 DM1BV7W DI DM1BV7W DM1BV7W DN Aliskiren DM1BV7W MI DE4LYSA DM1BV7W MN Cytochrome P450 3A4 (CYP3A4) DM1BV7W MT DME DM1BV7W MA Metabolism DM1BV7W RN Clinical pharmacokinetics and pharmacodynamics of aliskiren. Clin Pharmacokinet. 2008;47(8):515-31. DM1BV7W RU https://www.ncbi.nlm.nih.gov/pubmed/?term=18611061 DM1BV7W DI DM1BV7W DM1BV7W DN Aliskiren DM1BV7W MI DTPFTEQ DM1BV7W MN Organic anion transporting polypeptide 2B1 (SLCO2B1) DM1BV7W MT DTP DM1BV7W MA Substrate DM1BV7W RN Orange and apple juice greatly reduce the plasma concentrations of the OATP2B1 substrate aliskiren. Br J Clin Pharmacol. 2011 May;71(5):718-26. DM1BV7W RU http://www.ncbi.nlm.nih.gov/pubmed/21204914 DM1BV7W DI DM1BV7W DM1BV7W DN Aliskiren DM1BV7W MI DTUGYRD DM1BV7W MN P-glycoprotein 1 (ABCB1) DM1BV7W MT DTP DM1BV7W MA Substrate DM1BV7W RN Effects of the inhibition of intestinal P-glycoprotein on aliskiren pharmacokinetics in cynomolgus monkeys. Biopharm Drug Dispos. 2015 Jan;36(1):15-33. DM1BV7W RU http://www.ncbi.nlm.nih.gov/pubmed/25264342 DMME8LH DI DMME8LH DMME8LH DN Alitretinoin DMME8LH MI DE4LYSA DMME8LH MN Cytochrome P450 3A4 (CYP3A4) DMME8LH MT DME DMME8LH MA Metabolism DMME8LH RN Alitretinoin in dermatology-an update. Indian J Dermatol. 2015 Sep-Oct;60(5):520. DMME8LH RU https://www.ncbi.nlm.nih.gov/pubmed/?term=26538721 DMME8LH DI DMME8LH DMME8LH DN Alitretinoin DMME8LH MI TTISP28 DMME8LH MN Retinoic acid receptor beta (RARB) DMME8LH MT DTT DMME8LH MA Agonist DMME8LH RN Retinoic acid receptors and retinoid X receptors: interactions with endogenous retinoic acids. Proc Natl Acad Sci U S A. 1993 Jan 1;90(1):30-4. DMME8LH RU https://pubmed.ncbi.nlm.nih.gov/8380496 DMME8LH DI DMME8LH DMME8LH DN Alitretinoin DMME8LH MI TT1Q3IE DMME8LH MN Retinoic acid receptor gamma (RARG) DMME8LH MT DTT DMME8LH MA Modulator DMME8LH RN Retinoic acid receptors and retinoid X receptors: interactions with endogenous retinoic acids. Proc Natl Acad Sci U S A. 1993 Jan 1;90(1):30-4. DMME8LH RU https://pubmed.ncbi.nlm.nih.gov/8380496 DMME8LH DI DMME8LH DMME8LH DN Alitretinoin DMME8LH MI TT6PEUO DMME8LH MN Retinoic acid receptor RXR-alpha (RXRA) DMME8LH MT DTT DMME8LH MA Agonist DMME8LH RN Retinoic acid receptors and retinoid X receptors: interactions with endogenous retinoic acids. Proc Natl Acad Sci U S A. 1993 Jan 1;90(1):30-4. DMME8LH RU https://pubmed.ncbi.nlm.nih.gov/8380496 DMME8LH DI DMME8LH DMME8LH DN Alitretinoin DMME8LH MI TTKLV96 DMME8LH MN Retinoic acid receptor RXR-beta (RXRB) DMME8LH MT DTT DMME8LH MA Agonist DMME8LH RN Retinoic acid receptors and retinoid X receptors: interactions with endogenous retinoic acids. Proc Natl Acad Sci U S A. 1993 Jan 1;90(1):30-4. DMME8LH RU https://pubmed.ncbi.nlm.nih.gov/8380496 DMME8LH DI DMME8LH DMME8LH DN Alitretinoin DMME8LH MI TTH029C DMME8LH MN Retinoic acid receptor RXR-gamma (RXRG) DMME8LH MT DTT DMME8LH MA Agonist DMME8LH RN Retinoic acid receptors and retinoid X receptors: interactions with endogenous retinoic acids. Proc Natl Acad Sci U S A. 1993 Jan 1;90(1):30-4. DMME8LH RU https://pubmed.ncbi.nlm.nih.gov/8380496 DMB4HFI DI DMB4HFI DMB4HFI DN Alkavervir DMB4HFI MI TTNZRI3 DMB4HFI MN Synaptic vesicle amine transporter (SLC18A2) DMB4HFI MT DTT DMB4HFI MA Modulator DMB4HFI RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. DMB4HFI RU https://www.fda.gov/ DMNLHAC DI DMNLHAC DMNLHAC DN Allopregnanolone DMNLHAC MI DE7WS3H DMNLHAC MN Aldo-keto reductase 1B1 (AKR1B1) DMNLHAC MT DME DMNLHAC MA Metabolism DMNLHAC RN FDA Label of Brexanolone. The 2020 official website of the U.S. Food and Drug Administration. DMNLHAC RU https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/211371lbl.pdf DMNLHAC DI DMNLHAC DMNLHAC DN Allopregnanolone DMNLHAC MI TT1MPAY DMNLHAC MN GABA(A) receptor alpha-1 (GABRA1) DMNLHAC MT DTT DMNLHAC MA Inhibitor DMNLHAC RN Neurosteroid analogues. 10. The effect of methyl group substitution at the C-6 and C-7 positions on the GABA modulatory and anesthetic actions of (... J Med Chem. 2005 Apr 21;48(8):3051-9. DMNLHAC RU https://pubmed.ncbi.nlm.nih.gov/15828844 DMNLHAC DI DMNLHAC DMNLHAC DN Allopregnanolone DMNLHAC MI TTZA1NY DMNLHAC MN GABA(A) receptor beta-2 (GABRB2) DMNLHAC MT DTT DMNLHAC MA Inhibitor DMNLHAC RN Neurosteroid analogues. 10. The effect of methyl group substitution at the C-6 and C-7 positions on the GABA modulatory and anesthetic actions of (... J Med Chem. 2005 Apr 21;48(8):3051-9. DMNLHAC RU https://pubmed.ncbi.nlm.nih.gov/15828844 DMNLHAC DI DMNLHAC DMNLHAC DN Allopregnanolone DMNLHAC MI TTGXH6N DMNLHAC MN GABA(A) receptor delta (GABRD) DMNLHAC MT DTT DMNLHAC MA Inhibitor DMNLHAC RN Antibodies and venom peptides: new modalities for ion channels. Nat Rev Drug Discov. 2019 May;18(5):339-357. DMNLHAC RU https://pubmed.ncbi.nlm.nih.gov/30728472 DMNLHAC DI DMNLHAC DMNLHAC DN Allopregnanolone DMNLHAC MI TT06RH5 DMNLHAC MN GABA(A) receptor gamma-2 (GABRG2) DMNLHAC MT DTT DMNLHAC MA Inhibitor DMNLHAC RN Neurosteroid analogues. 10. The effect of methyl group substitution at the C-6 and C-7 positions on the GABA modulatory and anesthetic actions of (... J Med Chem. 2005 Apr 21;48(8):3051-9. DMNLHAC RU https://pubmed.ncbi.nlm.nih.gov/15828844 DMNLHAC DI DMNLHAC DMNLHAC DN Allopregnanolone DMNLHAC MI TTEX6LM DMNLHAC MN GABA(A) receptor gamma-3 (GABRG3) DMNLHAC MT DTT DMNLHAC MA Modulator DMNLHAC RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMNLHAC RU http://phrma-docs.phrma.org/files/dmfile/MID_Mental-Illness-2017-Drug-List_Final.pdf DMNLHAC DI DMNLHAC DMNLHAC DN Allopregnanolone DMNLHAC MI TTNJYV2 DMNLHAC MN Gamma-aminobutyric acid receptor (GAR) DMNLHAC MT DTT DMNLHAC MA Inhibitor DMNLHAC RN Neurosteroid analogues. 11. Alternative ring system scaffolds: gamma-aminobutyric acid receptor modulation and anesthetic actions of benz[f]indenes. J Med Chem. 2006 Jul 27;49(15):4595-605. DMNLHAC RU https://pubmed.ncbi.nlm.nih.gov/16854065 DMLPAOB DI DMLPAOB DMLPAOB DN Allopurinol DMLPAOB MI DT0OC1Q DMLPAOB MN Organic anion transporter 2 (SLC22A7) DMLPAOB MT DTP DMLPAOB MA Substrate DMLPAOB RN Isolation, characterization and differential gene expression of multispecific organic anion transporter 2 in mice. Mol Pharmacol. 2002 Jul;62(1):7-14. DMLPAOB RU http://www.ncbi.nlm.nih.gov/pubmed/12065749 DMLPAOB DI DMLPAOB DMLPAOB DN Allopurinol DMLPAOB MI DTVP67E DMLPAOB MN Organic anion transporter 3 (SLC22A8) DMLPAOB MT DTP DMLPAOB MA Substrate DMLPAOB RN Renal transport of organic compounds mediated by mouse organic anion transporter 3 (mOat3): further substrate specificity of mOat3. Drug Metab Dispos. 2004 May;32(5):479-83. DMLPAOB RU http://www.ncbi.nlm.nih.gov/pubmed/15100168 DMLPAOB DI DMLPAOB DMLPAOB DN Allopurinol DMLPAOB MI DEZV4AP DMLPAOB MN RNA cytidine acetyltransferase (hALP) DMLPAOB MT DME DMLPAOB MA Metabolism DMLPAOB RN Xanthine oxidase inhibition by allopurinol affects the reliability of urinary caffeine metabolic ratios as markers for N-acetyltransferase 2 and CYP1A2 activities. Eur J Clin Pharmacol. 1999 Jan;54(11):869-76. DMLPAOB RU https://www.ncbi.nlm.nih.gov/pubmed/?term=10027663 DMLPAOB DI DMLPAOB DMLPAOB DN Allopurinol DMLPAOB MI TT7RJY8 DMLPAOB MN Xanthine dehydrogenase/oxidase (XDH) DMLPAOB MT DTT DMLPAOB MA Inhibitor DMLPAOB RN Allopurinol: xanthine oxidase inhibitor. Tex Med. 1966 Jan;62(1):100-1. DMLPAOB RU https://pubmed.ncbi.nlm.nih.gov/5324754 DM0SYAN DI DM0SYAN DM0SYAN DN Almitrine DM0SYAN MI TTWK8D0 DM0SYAN MN Sodium pump subunit alpha-1 (ATP1A1) DM0SYAN MT DTT DM0SYAN MA Binder DM0SYAN RN Almitrine, a new kind of energy-transduction inhibitor acting on mitochondrial ATP synthase. Biochim Biophys Acta. 1989 Aug 3;975(3):325-9. DM0SYAN RU https://pubmed.ncbi.nlm.nih.gov/2527061 DM7I64Z DI DM7I64Z DM7I64Z DN Almogran DM7I64Z MI TT6MSOK DM7I64Z MN 5-HT 1D receptor (HTR1D) DM7I64Z MT DTT DM7I64Z MA Agonist DM7I64Z RN Efficacy and tolerability of subcutaneous almotriptan for the treatment of acute migraine: a randomized, double-blind, parallel-group, dose-finding study. Clin Ther. 2001 Nov;23(11):1867-75. DM7I64Z RU https://pubmed.ncbi.nlm.nih.gov/11768838 DMFG5ST DI DMFG5ST DMFG5ST DN Almotriptan malate DMFG5ST MI DES5XRU DMFG5ST MN Cytochrome P450 2C8 (CYP2C8) DMFG5ST MT DME DMFG5ST MA Metabolism DMFG5ST RN Identification of the human liver enzymes involved in the metabolism of the antimigraine agent almotriptan. Drug Metab Dispos. 2003 Apr;31(4):404-11. DMFG5ST RU https://www.ncbi.nlm.nih.gov/pubmed/?term=12642466 DMFG5ST DI DMFG5ST DMFG5ST DN Almotriptan malate DMFG5ST MI DECB0K3 DMFG5ST MN Cytochrome P450 2D6 (CYP2D6) DMFG5ST MT DME DMFG5ST MA Metabolism DMFG5ST RN Clinical pharmacokinetics of almotriptan, a serotonin 5-HT(1B/1D) receptor agonist for the treatment of migraine. Clin Pharmacokinet. 2005;44(3):237-46. DMFG5ST RU https://www.ncbi.nlm.nih.gov/pubmed/?term=15762767 DMFG5ST DI DMFG5ST DMFG5ST DN Almotriptan malate DMFG5ST MI DEVDYN7 DMFG5ST MN Cytochrome P450 2E1 (CYP2E1) DMFG5ST MT DME DMFG5ST MA Metabolism DMFG5ST RN Identification of the human liver enzymes involved in the metabolism of the antimigraine agent almotriptan. Drug Metab Dispos. 2003 Apr;31(4):404-11. DMFG5ST RU https://www.ncbi.nlm.nih.gov/pubmed/?term=12642466 DMFG5ST DI DMFG5ST DMFG5ST DN Almotriptan malate DMFG5ST MI DE4LYSA DMFG5ST MN Cytochrome P450 3A4 (CYP3A4) DMFG5ST MT DME DMFG5ST MA Metabolism DMFG5ST RN Clinical pharmacokinetics of almotriptan, a serotonin 5-HT(1B/1D) receptor agonist for the treatment of migraine. Clin Pharmacokinet. 2005;44(3):237-46. DMFG5ST RU https://www.ncbi.nlm.nih.gov/pubmed/?term=15762767 DMFG5ST DI DMFG5ST DMFG5ST DN Almotriptan malate DMFG5ST MI DEP76YL DMFG5ST MN Dimethylaniline oxidase 3 (FMO3) DMFG5ST MT DME DMFG5ST MA Metabolism DMFG5ST RN Identification of the human liver enzymes involved in the metabolism of the antimigraine agent almotriptan. Drug Metab Dispos. 2003 Apr;31(4):404-11. DMFG5ST RU https://www.ncbi.nlm.nih.gov/pubmed/?term=12642466 DMFG5ST DI DMFG5ST DMFG5ST DN Almotriptan malate DMFG5ST MI DEGTFWK DMFG5ST MN Mephenytoin 4-hydroxylase (CYP2C19) DMFG5ST MT DME DMFG5ST MA Metabolism DMFG5ST RN Identification of the human liver enzymes involved in the metabolism of the antimigraine agent almotriptan. Drug Metab Dispos. 2003 Apr;31(4):404-11. DMFG5ST RU https://www.ncbi.nlm.nih.gov/pubmed/?term=12642466 DMFG5ST DI DMFG5ST DMFG5ST DN Almotriptan malate DMFG5ST MI DERE4TU DMFG5ST MN Monoamine oxidase type A (MAO-A) DMFG5ST MT DME DMFG5ST MA Metabolism DMFG5ST RN Clinical pharmacokinetics of almotriptan, a serotonin 5-HT(1B/1D) receptor agonist for the treatment of migraine. Clin Pharmacokinet. 2005;44(3):237-46. DMFG5ST RU https://www.ncbi.nlm.nih.gov/pubmed/?term=15762767 DM8WI3R DI DM8WI3R DM8WI3R DN Alogliptin DM8WI3R MI DECB0K3 DM8WI3R MN Cytochrome P450 2D6 (CYP2D6) DM8WI3R MT DME DM8WI3R MA Metabolism DM8WI3R RN An update on the clinical pharmacology of the dipeptidyl peptidase 4 inhibitor alogliptin used for the treatment of type 2 diabetes mellitus. Clin Exp Pharmacol Physiol. 2015 Dec;42(12):1225-38. DM8WI3R RU https://www.ncbi.nlm.nih.gov/pubmed/?term=26218204 DM8WI3R DI DM8WI3R DM8WI3R DN Alogliptin DM8WI3R MI DE4LYSA DM8WI3R MN Cytochrome P450 3A4 (CYP3A4) DM8WI3R MT DME DM8WI3R MA Metabolism DM8WI3R RN An update on the clinical pharmacology of the dipeptidyl peptidase 4 inhibitor alogliptin used for the treatment of type 2 diabetes mellitus. Clin Exp Pharmacol Physiol. 2015 Dec;42(12):1225-38. DM8WI3R RU https://www.ncbi.nlm.nih.gov/pubmed/?term=26218204 DM8WI3R DI DM8WI3R DM8WI3R DN Alogliptin DM8WI3R MI TTDIGC1 DM8WI3R MN Dipeptidyl peptidase 4 (DPP-4) DM8WI3R MT DTT DM8WI3R MA Inhibitor DM8WI3R RN Clinical pipeline report, company report or official report of Takeda (2009). DM8WI3R RU http://www.takeda.com/pdf/usr/default/10_1_34992_2.pdf DML2A03 DI DML2A03 DML2A03 DN Alosetron DML2A03 MI TTPC4TU DML2A03 MN 5-HT 3A receptor (HTR3A) DML2A03 MT DTT DML2A03 MA Antagonist DML2A03 RN Efficacy of 5-HT3 antagonists and 5-HT4 agonists in irritable bowel syndrome: systematic review and meta-analysis. Am J Gastroenterol. 2009 Jul;104(7):1831-43; quiz 1844. DML2A03 RU https://pubmed.ncbi.nlm.nih.gov/19471254 DML2A03 DI DML2A03 DML2A03 DN Alosetron DML2A03 MI DEJGDUW DML2A03 MN Cytochrome P450 1A2 (CYP1A2) DML2A03 MT DME DML2A03 MA Metabolism DML2A03 RN Optimizing outcomes with alosetron hydrochloride in severe diarrhea-predominant irritable bowel syndrome. Therap Adv Gastroenterol. 2010 May;3(3):165-72. DML2A03 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=21180598 DML2A03 DI DML2A03 DML2A03 DN Alosetron DML2A03 MI DE5IED8 DML2A03 MN Cytochrome P450 2C9 (CYP2C9) DML2A03 MT DME DML2A03 MA Metabolism DML2A03 RN Effect of alosetron on the pharmacokinetics of fluoxetine. J Clin Pharmacol. 2001 Apr;41(4):455-8. DML2A03 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=11304903 DML2A03 DI DML2A03 DML2A03 DN Alosetron DML2A03 MI DE4LYSA DML2A03 MN Cytochrome P450 3A4 (CYP3A4) DML2A03 MT DME DML2A03 MA Metabolism DML2A03 RN Effect of alosetron on the pharmacokinetics of alprazolam. J Clin Pharmacol. 2001 Apr;41(4):452-4. DML2A03 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=11304902 DMEXMYK DI DMEXMYK DMEXMYK DN Alpelisib DMEXMYK MI DE4LYSA DMEXMYK MN Cytochrome P450 3A4 (CYP3A4) DMEXMYK MT DME DMEXMYK MA Metabolism DMEXMYK RN Comparison of 19F NMR and 14C measurements for the assessment of ADME of BYL719 (Alpelisib) in humans. Drug Metab Dispos. 2017 Aug;45(8):900-907. DMEXMYK RU https://www.ncbi.nlm.nih.gov/pubmed/?term=28566285 DMEXMYK DI DMEXMYK DMEXMYK DN Alpelisib DMEXMYK MI TTEUNMR DMEXMYK MN PI3-kinase alpha (PIK3CA) DMEXMYK MT DTT DMEXMYK MA Inhibitor DMEXMYK RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health Human Services. 2019 DMEXMYK RU https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/212526s000lbl.pdf DMXC1K9 DI DMXC1K9 DMXC1K9 DN Alpha 1-PI DMXC1K9 MI TTN9D8E DMXC1K9 MN Glutamate receptor ionotropic NMDA 2B (NMDAR2B) DMXC1K9 MT DTT DMXC1K9 MA Antagonist DMXC1K9 RN NMDA receptor stimulation induces reversible fission of the neuronal endoplasmic reticulum. PLoS One. 2009;4(4):e5250. DMXC1K9 RU https://pubmed.ncbi.nlm.nih.gov/19381304 DMXC1K9 DI DMXC1K9 DMXC1K9 DN Alpha 1-PI DMXC1K9 MI TT3NKIB DMXC1K9 MN Pancreatic elastase 1 (CELA1) DMXC1K9 MT DTT DMXC1K9 MA Inhibitor DMXC1K9 RN Elastase inhibitors. J Soc Biol. 2001;195(2):143-50. DMXC1K9 RU https://pubmed.ncbi.nlm.nih.gov/11723826 DMAS02L DI DMAS02L DMAS02L DN Alpha-acetyldigoxin DMAS02L MI TTYHPRQ DMAS02L MN Sodium pump (NaP) DMAS02L MT DTT DMAS02L MA Modulator DMAS02L RN Medicinal plants in therapy. Bull World Health Organ. 1985;63(6):965-81. DMAS02L RU https://pubmed.ncbi.nlm.nih.gov/3879679 DMN7Y9K DI DMN7Y9K DMN7Y9K DN Alpidem DMN7Y9K MI TTNJYV2 DMN7Y9K MN Gamma-aminobutyric acid receptor (GAR) DMN7Y9K MT DTT DMN7Y9K MA Inhibitor DMN7Y9K RN Synthesis and binding affinity of 2-phenylimidazo[1,2-alpha]pyridine derivatives for both central and peripheral benzodiazepine receptors. A new se... J Med Chem. 1997 Sep 12;40(19):3109-18. DMN7Y9K RU https://pubmed.ncbi.nlm.nih.gov/9301675 DMN7Y9K DI DMN7Y9K DMN7Y9K DN Alpidem DMN7Y9K MI TTPTXIN DMN7Y9K MN Translocator protein (TSPO) DMN7Y9K MT DTT DMN7Y9K MA Inhibitor DMN7Y9K RN Anxiolytic-like effects of N,N-dialkyl-2-phenylindol-3-ylglyoxylamides by modulation of translocator protein promoting neurosteroid biosynthesis. J Med Chem. 2008 Sep 25;51(18):5798-806. DMN7Y9K RU https://pubmed.ncbi.nlm.nih.gov/18729350 DMC7XDN DI DMC7XDN DMC7XDN DN Alprazolam DMC7XDN MI DE5IED8 DMC7XDN MN Cytochrome P450 2C9 (CYP2C9) DMC7XDN MT DME DMC7XDN MA Metabolism DMC7XDN RN Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. DMC7XDN RU https://www.ncbi.nlm.nih.gov/pubmed/?term=19515014 DMC7XDN DI DMC7XDN DMC7XDN DN Alprazolam DMC7XDN MI DE4LYSA DMC7XDN MN Cytochrome P450 3A4 (CYP3A4) DMC7XDN MT DME DMC7XDN MA Metabolism DMC7XDN RN No relevant interaction with alprazolam, caffeine, tolbutamide, and digoxin by treatment with a low-hyperforin St John's wort extract. Planta Med. 2005 Apr;71(4):331-7. DMC7XDN RU https://www.ncbi.nlm.nih.gov/pubmed/?term=15856409 DMC7XDN DI DMC7XDN DMC7XDN DN Alprazolam DMC7XDN MI DEIBDNY DMC7XDN MN Cytochrome P450 3A5 (CYP3A5) DMC7XDN MT DME DMC7XDN MA Metabolism DMC7XDN RN Identification and phenotype characterization of two CYP3A haplotypes causing different enzymatic capacity in fetal livers. Clin Pharmacol Ther. 2005 Apr;77(4):259-70. DMC7XDN RU https://www.ncbi.nlm.nih.gov/pubmed/?term=15903124 DMC7XDN DI DMC7XDN DMC7XDN DN Alprazolam DMC7XDN MI DERD86B DMC7XDN MN Cytochrome P450 3A7 (CYP3A7) DMC7XDN MT DME DMC7XDN MA Metabolism DMC7XDN RN Drug Interactions Flockhart Table DMC7XDN RU https://drug-interactions.medicine.iu.edu/Main-Table.aspx DMC7XDN DI DMC7XDN DMC7XDN DN Alprazolam DMC7XDN MI TTPTXIN DMC7XDN MN Translocator protein (TSPO) DMC7XDN MT DTT DMC7XDN MA Agonist DMC7XDN RN Comparison of five benzodiazepine-receptor agonists on buprenorphine-induced mu-opioid receptor regulation. J Pharmacol Sci. 2009 May;110(1):36-46. DMC7XDN RU https://pubmed.ncbi.nlm.nih.gov/19443999 DMWH7NQ DI DMWH7NQ DMWH7NQ DN Alprostadil DMWH7NQ MI DTCSGPB DMWH7NQ MN Multidrug resistance-associated protein 4 (ABCC4) DMWH7NQ MT DTP DMWH7NQ MA Substrate DMWH7NQ RN The human multidrug resistance protein MRP4 functions as a prostaglandin efflux transporter and is inhibited by nonsteroidal antiinflammatory drugs. Proc Natl Acad Sci U S A. 2003 Aug 5;100(16):9244-9. DMWH7NQ RU http://www.ncbi.nlm.nih.gov/pubmed/12835412 DMWH7NQ DI DMWH7NQ DMWH7NQ DN Alprostadil DMWH7NQ MI DTQ23VB DMWH7NQ MN Organic anion transporter 1 (SLC22A6) DMWH7NQ MT DTP DMWH7NQ MA Substrate DMWH7NQ RN Prostaglandin transporter (OATP2A1/SLCO2A1) contributes to local disposition of eicosapentaenoic acid-derived PGE3. Prostaglandins Other Lipid Mediat. 2016 Jan;122:10-7. DMWH7NQ RU http://www.ncbi.nlm.nih.gov/pubmed/26692285 DMWH7NQ DI DMWH7NQ DMWH7NQ DN Alprostadil DMWH7NQ MI DT021JD DMWH7NQ MN Organic anion transporting polypeptide 2A1 (SLCO2A1) DMWH7NQ MT DTP DMWH7NQ MA Substrate DMWH7NQ RN Cloning, in vitro expression, and tissue distribution of a human prostaglandin transporter cDNA(hPGT). J Clin Invest. 1996 Sep 1;98(5):1142-9. DMWH7NQ RU http://www.ncbi.nlm.nih.gov/pubmed/8787677 DMWH7NQ DI DMWH7NQ DMWH7NQ DN Alprostadil DMWH7NQ MI DTVNRXW DMWH7NQ MN Organic anion transporting polypeptide 3A1 (SLCO3A1) DMWH7NQ MT DTP DMWH7NQ MA Substrate DMWH7NQ RN Molecular characterization of human and rat organic anion transporter OATP-D. Am J Physiol Renal Physiol. 2003 Dec;285(6):F1188-97. DMWH7NQ RU http://www.ncbi.nlm.nih.gov/pubmed/14631946 DMWH7NQ DI DMWH7NQ DMWH7NQ DN Alprostadil DMWH7NQ MI DEHKSC6 DMWH7NQ MN Prostaglandin dehydrogenase 1 (HPGD) DMWH7NQ MT DME DMWH7NQ MA Metabolism DMWH7NQ RN Effect of calcium ionophore A23187 on prostaglandin synthase type 2 and 15-hydroxy-prostaglandin dehydrogenase expression in human chorion trophoblast cells. Am J Obstet Gynecol. 2008 Nov;199(5):554.e1-8. DMWH7NQ RU https://www.ncbi.nlm.nih.gov/pubmed/?term=18639206 DMWH7NQ DI DMWH7NQ DMWH7NQ DN Alprostadil DMWH7NQ MI TT1ZAVI DMWH7NQ MN Prostaglandin E2 receptor EP2 (PTGER2) DMWH7NQ MT DTT DMWH7NQ MA Agonist DMWH7NQ RN Emerging drugs for diabetic foot ulcers. Expert Opin Emerg Drugs. 2006 Nov;11(4):709-24. DMWH7NQ RU https://pubmed.ncbi.nlm.nih.gov/17064227 DMWH7NQ DI DMWH7NQ DMWH7NQ DN Alprostadil DMWH7NQ MI TT2O84V DMWH7NQ MN Thromboxane A2 receptor (TBXA2R) DMWH7NQ MT DTT DMWH7NQ MA Modulator DMWH7NQ RN Flow after prostaglandin E1 is mediated by receptor-coupled adenylyl cyclase in human anterior segments. Invest Ophthalmol Vis Sci. 1999 Oct;40(11):2622-6. DMWH7NQ RU https://pubmed.ncbi.nlm.nih.gov/10509658 DMB47TQ DI DMB47TQ DMB47TQ DN Alseroxylon DMB47TQ MI TTNZRI3 DMB47TQ MN Synaptic vesicle amine transporter (SLC18A2) DMB47TQ MT DTT DMB47TQ MA Blocker DMB47TQ RN Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. DMB47TQ RU https://pubmed.ncbi.nlm.nih.gov/17016423 DMRJ3YX DI DMRJ3YX DMRJ3YX DN Alteplase DMRJ3YX MI TTP86E2 DMRJ3YX MN Plasminogen (PLG) DMRJ3YX MT DTT DMRJ3YX MA Activator DMRJ3YX RN Thrombolytic therapies: the current state of affairs. J Endovasc Ther. 2005 Apr;12(2):224-32. DMRJ3YX RU https://pubmed.ncbi.nlm.nih.gov/15823070 DMKLAYG DI DMKLAYG DMKLAYG DN Altretamine DMKLAYG MI TTUTN1I DMKLAYG MN Human Deoxyribonucleic acid (hDNA) DMKLAYG MT DTT DMKLAYG MA Breaker DMKLAYG RN Synergy of irofulven in combination with other DNA damaging agents: synergistic interaction with altretamine, alkylating, and platinum-derived agen... Cancer Chemother Pharmacol. 2008 Dec;63(1):19-26. DMKLAYG RU https://pubmed.ncbi.nlm.nih.gov/18305940 DMO9WDS DI DMO9WDS DMO9WDS DN Altropane DMO9WDS MI TTVBI8W DMO9WDS MN Dopamine transporter (DAT) DMO9WDS MT DTT DMO9WDS MA Inhibitor DMO9WDS RN Rapid detection of Parkinson's disease by SPECT with altropane: a selective ligand for dopamine transporters. Synapse. 1998 Jun;29(2):128-41. DMO9WDS RU https://pubmed.ncbi.nlm.nih.gov/9593103 DM6ECN9 DI DM6ECN9 DM6ECN9 DN Aluminium DM6ECN9 MI TTWK8D0 DM6ECN9 MN Sodium pump subunit alpha-1 (ATP1A1) DM6ECN9 MT DTT DM6ECN9 MA Binder DM6ECN9 RN The inhibitory effect of aluminium on the (Na+/K+)ATPase activity of rat brain cortex synaptosomes. J Inorg Biochem. 2003 Sep 15;97(1):143-50. DM6ECN9 RU https://pubmed.ncbi.nlm.nih.gov/14507470 DMHR8KW DI DMHR8KW DMHR8KW DN Alvimopan DMHR8KW MI TTKWM86 DMHR8KW MN Opioid receptor mu (MOP) DMHR8KW MT DTT DMHR8KW MA Antagonist DMHR8KW RN Alvimopan for postoperative ileus. Am J Health Syst Pharm. 2009 Jul 15;66(14):1267-77. DMHR8KW RU https://pubmed.ncbi.nlm.nih.gov/19574601 DMS3YE9 DI DMS3YE9 DMS3YE9 DN Amantadine DMS3YE9 MI TTXT3PU DMS3YE9 MN Influenza M2 protein (Influ M) DMS3YE9 MT DTT DMS3YE9 MA Inhibitor DMS3YE9 RN Discovery of spiro-piperidine inhibitors and their modulation of the dynamics of the M2 proton channel from influenza A virus. J Am Chem Soc. 2009 Jun 17;131(23):8066-76. DMS3YE9 RU https://pubmed.ncbi.nlm.nih.gov/19469531 DMS3YE9 DI DMS3YE9 DMS3YE9 DN Amantadine DMS3YE9 MI DT9IDPW DMS3YE9 MN Organic cation transporter 2 (SLC22A2) DMS3YE9 MT DTP DMS3YE9 MA Substrate DMS3YE9 RN Human neurons express the polyspecific cation transporter hOCT2, which translocates monoamine neurotransmitters, amantadine, and memantine. Mol Pharmacol. 1998 Aug;54(2):342-52. DMS3YE9 RU http://www.ncbi.nlm.nih.gov/pubmed/9687576 DMOP0BL DI DMOP0BL DMOP0BL DN Ambenonium DMOP0BL MI TT1RS9F DMOP0BL MN Acetylcholinesterase (AChE) DMOP0BL MT DTT DMOP0BL MA Inhibitor DMOP0BL RN Alpha6-containing nicotinic acetylcholine receptors dominate the nicotine control of dopamine neurotransmission in nucleus accumbens. Neuropsychopharmacology. 2008 Aug;33(9):2158-66. DMOP0BL RU https://pubmed.ncbi.nlm.nih.gov/18033235 DMD1QXW DI DMD1QXW DMD1QXW DN Ambrisentan DMD1QXW MI DE4LYSA DMD1QXW MN Cytochrome P450 3A4 (CYP3A4) DMD1QXW MT DME DMD1QXW MA Metabolism DMD1QXW RN Clinical pharmacokinetics and drug-drug interactions of endothelin receptor antagonists in pulmonary arterial hypertension. J Clin Pharmacol. 2012 Dec;52(12):1784-805. DMD1QXW RU https://www.ncbi.nlm.nih.gov/pubmed/?term=22205719 DMD1QXW DI DMD1QXW DMD1QXW DN Ambrisentan DMD1QXW MI TTKRD0G DMD1QXW MN Endothelin A receptor (EDNRA) DMD1QXW MT DTT DMD1QXW MA Antagonist DMD1QXW RN Clinical pipeline report, company report or official report of GlaxoSmithKline (2009). DMD1QXW RU http://www.gsk.com/investors/product_pipeline/docs/gsk-pipeline-feb09.pdf DMD1QXW DI DMD1QXW DMD1QXW DN Ambrisentan DMD1QXW MI DEGTFWK DMD1QXW MN Mephenytoin 4-hydroxylase (CYP2C19) DMD1QXW MT DME DMD1QXW MA Metabolism DMD1QXW RN Clinical pharmacokinetics and drug-drug interactions of endothelin receptor antagonists in pulmonary arterial hypertension. J Clin Pharmacol. 2012 Dec;52(12):1784-805. DMD1QXW RU https://www.ncbi.nlm.nih.gov/pubmed/?term=22205719 DMD1QXW DI DMD1QXW DMD1QXW DN Ambrisentan DMD1QXW MI DTUGYRD DMD1QXW MN P-glycoprotein 1 (ABCB1) DMD1QXW MT DTP DMD1QXW MA Substrate DMD1QXW RN Potential for pharmacokinetic interactions between ambrisentan and cyclosporine. Clin Pharmacol Ther. 2010 Oct;88(4):513-20. DMD1QXW RU http://www.ncbi.nlm.nih.gov/pubmed/20811346 DMD1QXW DI DMD1QXW DMD1QXW DN Ambrisentan DMD1QXW MI DEF2WXN DMD1QXW MN UDP-glucuronosyltransferase 1A3 (UGT1A3) DMD1QXW MT DME DMD1QXW MA Metabolism DMD1QXW RN Clinical pharmacokinetics and drug-drug interactions of endothelin receptor antagonists in pulmonary arterial hypertension. J Clin Pharmacol. 2012 Dec;52(12):1784-805. DMD1QXW RU https://www.ncbi.nlm.nih.gov/pubmed/?term=22205719 DMD1QXW DI DMD1QXW DMD1QXW DN Ambrisentan DMD1QXW MI DE85D2P DMD1QXW MN UDP-glucuronosyltransferase 1A9 (UGT1A9) DMD1QXW MT DME DMD1QXW MA Metabolism DMD1QXW RN Clinical pharmacokinetics and drug-drug interactions of endothelin receptor antagonists in pulmonary arterial hypertension. J Clin Pharmacol. 2012 Dec;52(12):1784-805. DMD1QXW RU https://www.ncbi.nlm.nih.gov/pubmed/?term=22205719 DMD1QXW DI DMD1QXW DMD1QXW DN Ambrisentan DMD1QXW MI DEB3CV1 DMD1QXW MN UDP-glucuronosyltransferase 2B7 (UGT2B7) DMD1QXW MT DME DMD1QXW MA Metabolism DMD1QXW RN Clinical pharmacokinetics and drug-drug interactions of endothelin receptor antagonists in pulmonary arterial hypertension. J Clin Pharmacol. 2012 Dec;52(12):1784-805. DMD1QXW RU https://www.ncbi.nlm.nih.gov/pubmed/?term=22205719 DMWJE9D DI DMWJE9D DMWJE9D DN Ambroxol DMWJE9D MI DE4LYSA DMWJE9D MN Cytochrome P450 3A4 (CYP3A4) DMWJE9D MT DME DMWJE9D MA Metabolism DMWJE9D RN Summary of information on human CYP enzymes: human P450 metabolism data. Drug Metab Rev. 2002 Feb-May;34(1-2):83-448. DMWJE9D RU https://www.ncbi.nlm.nih.gov/pubmed/?term=11996015 DMM1JL9 DI DMM1JL9 DMM1JL9 DN Amcinonide DMM1JL9 MI DE4LYSA DMM1JL9 MN Cytochrome P450 3A4 (CYP3A4) DMM1JL9 MT DME DMM1JL9 MA Metabolism DMM1JL9 RN Regulation of drug-metabolizing cytochrome P450 enzymes by glucocorticoids. Drug Metab Rev. 2010 Nov;42(4):621-35. DMM1JL9 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=20482443 DMM1JL9 DI DMM1JL9 DMM1JL9 DN Amcinonide DMM1JL9 MI TTP3UTW DMM1JL9 MN Steroid hormone receptor ERR (ESRR) DMM1JL9 MT DTT DMM1JL9 MA Modulator DMM1JL9 RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. DMM1JL9 RU https://www.fda.gov/ DMIG6FY DI DMIG6FY DMIG6FY DN Amdinocillin DMIG6FY MI TTHWB7G DMIG6FY MN Bacterial Penicillin binding protein 2 (Bact mrdA) DMIG6FY MT DTT DMIG6FY MA Inhibitor DMIG6FY RN Growth of Escherichia coli: significance of peptidoglycan degradation during elongation and septation. J Bacteriol. 2008 Jun;190(11):3914-22. DMIG6FY RU https://pubmed.ncbi.nlm.nih.gov/18390656 DM6I2WQ DI DM6I2WQ DM6I2WQ DN Amezinium DM6I2WQ MI TT2NUT5 DM6I2WQ MN Adrenergic receptor alpha-2C (ADRA2C) DM6I2WQ MT DTT DM6I2WQ MA Modulator DM6I2WQ RN Pharmacology of amezinium, a novel antihypotensive drug. III. Studies on the mechanism of action. Arzneimittelforschung. 1981;31(9a):1558-65. DM6I2WQ RU https://pubmed.ncbi.nlm.nih.gov/7197970 DM9YSNQ DI DM9YSNQ DM9YSNQ DN Amfepramone DM9YSNQ MI TTAWNKZ DM9YSNQ MN Norepinephrine transporter (NET) DM9YSNQ MT DTT DM9YSNQ MA Inhibitor DM9YSNQ RN Pharmacotherapy for obesity. Drugs. 2005;65(10):1391-418. DM9YSNQ RU https://pubmed.ncbi.nlm.nih.gov/15977970 DM9YSNQ DI DM9YSNQ DM9YSNQ DN Amfepramone DM9YSNQ MI TT3ROYC DM9YSNQ MN Serotonin transporter (SERT) DM9YSNQ MT DTT DM9YSNQ MA Inhibitor DM9YSNQ RN Pharmacotherapy for obesity. Drugs. 2005;65(10):1391-418. DM9YSNQ RU https://pubmed.ncbi.nlm.nih.gov/15977970 DMK08L3 DI DMK08L3 DMK08L3 DN Amifampridine DMK08L3 MI DE7OAB3 DMK08L3 MN N-acetyltransferase 1 (NAT1) DMK08L3 MT DME DMK08L3 MA Metabolism DMK08L3 RN Genetic variation in aryl N-acetyltransferase results in significant differences in the pharmacokinetic and safety profiles of amifampridine (3,4-diaminopyridine) phosphate. Pharmacol Res Perspect. 2015 Feb;3(1):e00099. DMK08L3 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=25692017 DMK08L3 DI DMK08L3 DMK08L3 DN Amifampridine DMK08L3 MI DER7TA0 DMK08L3 MN N-acetyltransferase 2 (NAT2) DMK08L3 MT DME DMK08L3 MA Metabolism DMK08L3 RN Genetic variation in aryl N-acetyltransferase results in significant differences in the pharmacokinetic and safety profiles of amifampridine (3,4-diaminopyridine) phosphate. Pharmacol Res Perspect. 2015 Feb;3(1):e00099. DMK08L3 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=25692017 DMK08L3 DI DMK08L3 DMK08L3 DN Amifampridine DMK08L3 MI TT1VOHK DMK08L3 MN Potassium channel unspecific (KC) DMK08L3 MT DTT DMK08L3 MA Blocker DMK08L3 RN 2018 FDA drug approvals.Nat Rev Drug Discov. 2019 Feb;18(2):85-89. DMK08L3 RU https://pubmed.ncbi.nlm.nih.gov/30710142 DM5FL14 DI DM5FL14 DM5FL14 DN Amifostine DM5FL14 MI DEVEFKM DM5FL14 MN Alkaline phosphatase (ALPL) DM5FL14 MT DME DM5FL14 MA Metabolism DM5FL14 RN Pharmacokinetic profile of amifostine. Semin Oncol. 1996 Aug;23(4 Suppl 8):18-22. DM5FL14 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=8783662 DM5FL14 DI DM5FL14 DM5FL14 DN Amifostine DM5FL14 MI TT0C9DV DM5FL14 MN Toxic reactive metabolite (TRM) DM5FL14 MT DTT DM5FL14 MA Modulator DM5FL14 RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015 DM5FL14 RU https://www.accessdata.fda.gov/scripts/cder/drugsatfda/ DM5PDRB DI DM5PDRB DM5PDRB DN Amikacin DM5PDRB MI DEWPAJD DM5PDRB MN Aminoglycoside O-phosphotransferase (aphA6) DM5PDRB MT DME DM5PDRB MA Metabolism DM5PDRB RN Relationship between antimicrobial resistance and aminoglycoside-modifying enzyme gene expressions in Acinetobacter baumannii. Chin Med J (Engl). 2005 Jan 20;118(2):141-5. DM5PDRB RU https://pubmed.ncbi.nlm.nih.gov/15667800 DM5PDRB DI DM5PDRB DM5PDRB DN Amikacin DM5PDRB MI DE1C8Q4 DM5PDRB MN Endoglucanase A (EGA) DM5PDRB MT DME DM5PDRB MA Metabolism DM5PDRB RN Expression of Clostridium thermocellum endoglucanase gene in Lactobacillus gasseri and Lactobacillus johnsonii and characterization of the genetically modified probiotic lactobacilli. Curr Microbiol. 2000 Apr;40(4):257-63. DM5PDRB RU https://pubmed.ncbi.nlm.nih.gov/10688695 DM5PDRB DI DM5PDRB DM5PDRB DN Amikacin DM5PDRB MI DE2AZTG DM5PDRB MN Endoglucanase Y (EGY) DM5PDRB MT DME DM5PDRB MA Metabolism DM5PDRB RN Expression of Clostridium thermocellum endoglucanase gene in Lactobacillus gasseri and Lactobacillus johnsonii and characterization of the genetically modified probiotic lactobacilli. Curr Microbiol. 2000 Apr;40(4):257-63. DM5PDRB RU https://pubmed.ncbi.nlm.nih.gov/10688695 DM5PDRB DI DM5PDRB DM5PDRB DN Amikacin DM5PDRB MI TTQ8KVI DM5PDRB MN Staphylococcus 30S ribosomal subunit (Stap-coc pbp2) DM5PDRB MT DTT DM5PDRB MA Binder DM5PDRB RN Bacterial resistance to aminoglycosides and beta-lactams: the Tn1331 transposon paradigm. Front Biosci. 2000 Jan 1;5:D20-9. DM5PDRB RU https://pubmed.ncbi.nlm.nih.gov/10702385 DMRTSGP DI DMRTSGP DMRTSGP DN Amiloride DMRTSGP MI TTRJYB6 DMRTSGP MN Acid-sensing ion channel 1 (ASIC1) DMRTSGP MT DTT DMRTSGP MA Modulator DMRTSGP RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. DMRTSGP RU https://www.fda.gov/ DMRTSGP DI DMRTSGP DMRTSGP DN Amiloride DMRTSGP MI DTT79CX DMRTSGP MN Organic cation transporter 1 (SLC22A1) DMRTSGP MT DTP DMRTSGP MA Substrate DMRTSGP RN Identification of novel substrates and structure-activity relationship of cellular uptake mediated by human organic cation transporters 1 and 2. J Med Chem. 2013 Sep 26;56(18):7232-42. DMRTSGP RU http://www.ncbi.nlm.nih.gov/pubmed/23984907 DMRTSGP DI DMRTSGP DMRTSGP DN Amiloride DMRTSGP MI DT9IDPW DMRTSGP MN Organic cation transporter 2 (SLC22A2) DMRTSGP MT DTP DMRTSGP MA Substrate DMRTSGP RN Characterization of regulatory mechanisms and states of human organic cation transporter 2. Am J Physiol Cell Physiol. 2006 Jun;290(6):C1521-31. DMRTSGP RU http://www.ncbi.nlm.nih.gov/pubmed/16394027 DMFGND4 DI DMFGND4 DMFGND4 DN Aminocaproic acid DMFGND4 MI TTP86E2 DMFGND4 MN Plasminogen (PLG) DMFGND4 MT DTT DMFGND4 MA Inhibitor DMFGND4 RN The blockage of the high-affinity lysine binding sites of plasminogen by EACA significantly inhibits prourokinase-induced plasminogen activation. Biochim Biophys Acta. 2002 Apr 29;1596(2):182-92. DMFGND4 RU https://pubmed.ncbi.nlm.nih.gov/12007600 DMFGND4 DI DMFGND4 DMFGND4 DN Aminocaproic acid DMFGND4 MI TTXAGYU DMFGND4 MN Tissue-type plasminogen activator (PLAT) DMFGND4 MT DTT DMFGND4 MA Inhibitor DMFGND4 RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMFGND4 RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMWFHMZ DI DMWFHMZ DMWFHMZ DN Aminoglutethimide DMWFHMZ MI TTSZLWK DMWFHMZ MN Aromatase (CYP19A1) DMWFHMZ MT DTT DMWFHMZ MA Inhibitor DMWFHMZ RN Aminoglutethimide-induced protein free radical formation on myeloperoxidase: a potential mechanism of agranulocytosis. Chem Res Toxicol. 2007 Jul;20(7):1038-45. DMWFHMZ RU https://pubmed.ncbi.nlm.nih.gov/17602675 DMWFHMZ DI DMWFHMZ DMWFHMZ DN Aminoglutethimide DMWFHMZ MI TTSYVO6 DMWFHMZ MN Cholesterol desmolase (CYP11A1) DMWFHMZ MT DTT DMWFHMZ MA Inhibitor DMWFHMZ RN Breakdown of Th cell immune responses and steroidogenic CYP11A1 expression in CD4+ T cells in a murine model implanted with B16 melanoma. Cell Immunol. 2000 Nov 25;206(1):7-15. DMWFHMZ RU https://pubmed.ncbi.nlm.nih.gov/11161433 DMS4BLQ DI DMS4BLQ DMS4BLQ DN Aminolevulinic acid hci DMS4BLQ MI TTJHKYD DMS4BLQ MN Delta-aminolevulinic acid dehydratase (ALAD) DMS4BLQ MT DTT DMS4BLQ MA Inhibitor DMS4BLQ RN Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. Nat Biotechnol. 2003 May;21(5):566-9. DMS4BLQ RU https://pubmed.ncbi.nlm.nih.gov/12665801 DMS4BLQ DI DMS4BLQ DMS4BLQ DN Aminolevulinic acid hci DMS4BLQ MI DT9G7XN DMS4BLQ MN Peptide transporter 1 (SLC15A1) DMS4BLQ MT DTP DMS4BLQ MA Substrate DMS4BLQ RN Transport of the photodynamic therapy agent 5-aminolevulinic acid by distinct H+-coupled nutrient carriers coexpressed in the small intestine. J Pharmacol Exp Ther. 2010 Jan;332(1):220-8. DMS4BLQ RU http://www.ncbi.nlm.nih.gov/pubmed/19789362 DMS4BLQ DI DMS4BLQ DMS4BLQ DN Aminolevulinic acid hci DMS4BLQ MI DT8QKNP DMS4BLQ MN Peptide transporter 2 (SLC15A2) DMS4BLQ MT DTP DMS4BLQ MA Substrate DMS4BLQ RN PEPT2-mediated transport of 5-aminolevulinic acid and carnosine in astrocytes. Brain Res. 2006 Nov 29;1122(1):18-23. DMS4BLQ RU http://www.ncbi.nlm.nih.gov/pubmed/17034769 DMS4BLQ DI DMS4BLQ DMS4BLQ DN Aminolevulinic acid hci DMS4BLQ MI DETBNY4 DMS4BLQ MN Porphobilinogen synthase (ALAD) DMS4BLQ MT DME DMS4BLQ MA Metabolism DMS4BLQ RN Modifying effects of delta-Aminolevulinate dehydratase polymorphism on blood lead levels and ALAD activity. Toxicol Lett. 2018 Oct 1;295:351-356. DMS4BLQ RU https://www.ncbi.nlm.nih.gov/pubmed/?term=30025905 DMS4BLQ DI DMS4BLQ DMS4BLQ DN Aminolevulinic acid hci DMS4BLQ MI DT48WEM DMS4BLQ MN Proton-coupled amino acid transporter 1 (SLC36A1) DMS4BLQ MT DTP DMS4BLQ MA Substrate DMS4BLQ RN Delta-aminolevulinic acid is a substrate for the amino acid transporter SLC36A1 (hPAT1). Br J Pharmacol. 2010 Mar;159(6):1339-53. DMS4BLQ RU http://www.ncbi.nlm.nih.gov/pubmed/20128809 DMWNHPC DI DMWNHPC DMWNHPC DN Aminolevulinic Acid Hydrochloride DMWNHPC MI TTNFMS9 DMWNHPC MN Protoporphyrinogen oxidase (PPOX) DMWNHPC MT DTT DMWNHPC MA Modulator DMWNHPC RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. DMWNHPC RU https://www.fda.gov/ DML2NIB DI DML2NIB DML2NIB DN Aminophylline DML2NIB MI DEJGDUW DML2NIB MN Cytochrome P450 1A2 (CYP1A2) DML2NIB MT DME DML2NIB MA Metabolism DML2NIB RN Lack of effect of olanzapine on the pharmacokinetics of a single aminophylline dose in healthy men. Pharmacotherapy. 1998 Nov-Dec;18(6):1237-48. DML2NIB RU https://www.ncbi.nlm.nih.gov/pubmed/?term=9855322 DML2NIB DI DML2NIB DML2NIB DN Aminophylline DML2NIB MI DEVDYN7 DML2NIB MN Cytochrome P450 2E1 (CYP2E1) DML2NIB MT DME DML2NIB MA Metabolism DML2NIB RN Theophylline metabolism in human liver microsomes: inhibition studies. J Pharmacol Exp Ther. 1996 Mar;276(3):912-7. DML2NIB RU https://www.ncbi.nlm.nih.gov/pubmed/?term=8786569 DML2NIB DI DML2NIB DML2NIB DN Aminophylline DML2NIB MI TT06AWU DML2NIB MN Phosphodiesterase 3A (PDE3A) DML2NIB MT DTT DML2NIB MA Inhibitor DML2NIB RN Topical fat reduction from the waist. Diabetes Obes Metab. 2007 May;9(3):300-3. DML2NIB RU https://pubmed.ncbi.nlm.nih.gov/17391155 DMENSL5 DI DMENSL5 DMENSL5 DN Aminosalicylic acid DMENSL5 MI TTYZVDJ DMENSL5 MN Dihydrofolate reductase (DHFR) DMENSL5 MT DTT DMENSL5 MA Modulator DMENSL5 RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. DMENSL5 RU https://www.fda.gov/ DMENSL5 DI DMENSL5 DMENSL5 DN Aminosalicylic acid DMENSL5 MI DER7TA0 DMENSL5 MN N-acetyltransferase 2 (NAT2) DMENSL5 MT DME DMENSL5 MA Metabolism DMENSL5 RN Importance of the evaluation of N-acetyltransferase enzyme activity prior to 5-aminosalicylic acid medication for ulcerative colitis. Inflamm Bowel Dis. 2016 Aug;22(8):1793-802. DMENSL5 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=27416043 DMENSL5 DI DMENSL5 DMENSL5 DN Aminosalicylic acid DMENSL5 MI TT8NGED DMENSL5 MN Prostaglandin G/H synthase 1 (COX-1) DMENSL5 MT DTT DMENSL5 MA Modulator DMENSL5 RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. DMENSL5 RU https://www.fda.gov/ DMENSL5 DI DMENSL5 DMENSL5 DN Aminosalicylic acid DMENSL5 MI TTVKILB DMENSL5 MN Prostaglandin G/H synthase 2 (COX-2) DMENSL5 MT DTT DMENSL5 MA Modulator DMENSL5 RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. DMENSL5 RU https://www.fda.gov/ DMENSL5 DI DMENSL5 DMENSL5 DN Aminosalicylic acid DMENSL5 MI DTKWJH3 DMENSL5 MN Sodium-coupled neutral amino acid transporter 3 (SLC38A3) DMENSL5 MT DTP DMENSL5 MA Substrate DMENSL5 RN Identification of amino acids imparting acceptor substrate selectivity to human arylamine acetyltransferases NAT1 and NAT2. Biochem J. 2000 May 15;348 Pt 1:159-66. DMENSL5 RU http://www.ncbi.nlm.nih.gov/pubmed/10794727 DMUTEX3 DI DMUTEX3 DMUTEX3 DN Amiodarone DMUTEX3 MI DE6OQ3W DMUTEX3 MN Cytochrome P450 1A1 (CYP1A1) DMUTEX3 MT DME DMUTEX3 MA Metabolism DMUTEX3 RN A significant role of human cytochrome P450 2C8 in amiodarone N-deethylation: an approach to predict the contribution with relative activity factor. Drug Metab Dispos. 2000 Nov;28(11):1303-10. DMUTEX3 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=11038157 DMUTEX3 DI DMUTEX3 DMUTEX3 DN Amiodarone DMUTEX3 MI DEJGDUW DMUTEX3 MN Cytochrome P450 1A2 (CYP1A2) DMUTEX3 MT DME DMUTEX3 MA Metabolism DMUTEX3 RN Role of desethylamiodarone in the anticoagulant effect of concurrent amiodarone and warfarin therapy. J Cardiovasc Pharmacol Ther. 2001 Oct;6(4):363-7. DMUTEX3 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=11907638 DMUTEX3 DI DMUTEX3 DMUTEX3 DN Amiodarone DMUTEX3 MI DES5XRU DMUTEX3 MN Cytochrome P450 2C8 (CYP2C8) DMUTEX3 MT DME DMUTEX3 MA Metabolism DMUTEX3 RN Functional characterization of five novel CYP2C8 variants, G171S, R186X, R186G, K247R, and K383N, found in a Japanese population. Drug Metab Dispos. 2005 May;33(5):630-6. DMUTEX3 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=15716363 DMUTEX3 DI DMUTEX3 DMUTEX3 DN Amiodarone DMUTEX3 MI DE5IED8 DMUTEX3 MN Cytochrome P450 2C9 (CYP2C9) DMUTEX3 MT DME DMUTEX3 MA Metabolism DMUTEX3 RN Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. DMUTEX3 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=19515014 DMUTEX3 DI DMUTEX3 DMUTEX3 DN Amiodarone DMUTEX3 MI DECB0K3 DMUTEX3 MN Cytochrome P450 2D6 (CYP2D6) DMUTEX3 MT DME DMUTEX3 MA Metabolism DMUTEX3 RN Potentially significant drug interactions of class III antiarrhythmic drugs. Drug Saf. 2003;26(6):421-38. DMUTEX3 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=12688833 DMUTEX3 DI DMUTEX3 DMUTEX3 DN Amiodarone DMUTEX3 MI DE4LYSA DMUTEX3 MN Cytochrome P450 3A4 (CYP3A4) DMUTEX3 MT DME DMUTEX3 MA Metabolism DMUTEX3 RN The metabolism of amiodarone by various CYP isoenzymes of human and rat, and the inhibitory influence of ketoconazole. J Pharm Pharm Sci. 2008;11(1):147-59. DMUTEX3 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=18445370 DMUTEX3 DI DMUTEX3 DMUTEX3 DN Amiodarone DMUTEX3 MI DEGTFWK DMUTEX3 MN Mephenytoin 4-hydroxylase (CYP2C19) DMUTEX3 MT DME DMUTEX3 MA Metabolism DMUTEX3 RN A significant role of human cytochrome P450 2C8 in amiodarone N-deethylation: an approach to predict the contribution with relative activity factor. Drug Metab Dispos. 2000 Nov;28(11):1303-10. DMUTEX3 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=11038157 DMUTEX3 DI DMUTEX3 DMUTEX3 DN Amiodarone DMUTEX3 MI DTUGYRD DMUTEX3 MN P-glycoprotein 1 (ABCB1) DMUTEX3 MT DTP DMUTEX3 MA Substrate DMUTEX3 RN Mammalian drug efflux transporters of the ATP binding cassette (ABC) family in multidrug resistance: A review of the past decade. Cancer Lett. 2016 Jan 1;370(1):153-64. DMUTEX3 RU http://www.ncbi.nlm.nih.gov/pubmed/26499806 DMUTEX3 DI DMUTEX3 DMUTEX3 DN Amiodarone DMUTEX3 MI TT1VOHK DMUTEX3 MN Potassium channel unspecific (KC) DMUTEX3 MT DTT DMUTEX3 MA Modulator DMUTEX3 RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. DMUTEX3 RU https://www.fda.gov/ DMSJVAM DI DMSJVAM DMSJVAM DN Amisulpride DMSJVAM MI TTEX248 DMSJVAM MN Dopamine D2 receptor (D2R) DMSJVAM MT DTT DMSJVAM MA Antagonist DMSJVAM RN Mechanism of action of atypical antipsychotic drugs and the neurobiology of schizophrenia. CNS Drugs. 2006;20(5):389-409. DMSJVAM RU https://pubmed.ncbi.nlm.nih.gov/16696579 DMSJVAM DI DMSJVAM DMSJVAM DN Amisulpride DMSJVAM MI DTUGYRD DMSJVAM MN P-glycoprotein 1 (ABCB1) DMSJVAM MT DTP DMSJVAM MA Substrate DMSJVAM RN Identification of P-glycoprotein substrates and inhibitors among psychoactive compounds--implications for pharmacokinetics of selected substrates. J Pharm Pharmacol. 2004 Aug;56(8):967-75. DMSJVAM RU http://www.ncbi.nlm.nih.gov/pubmed/15285840 DMK7F9S DI DMK7F9S DMK7F9S DN Amitriptyline DMK7F9S MI DEJGDUW DMK7F9S MN Cytochrome P450 1A2 (CYP1A2) DMK7F9S MT DME DMK7F9S MA Metabolism DMK7F9S RN The genetic profiles of CYP1A1, CYP1A2 and CYP2E1 enzymes as susceptibility factor in xenobiotic toxicity in Turkish population. Saudi Pharm J. 2017 Feb;25(2):294-297. DMK7F9S RU https://www.ncbi.nlm.nih.gov/pubmed/?term=28344482 DMK7F9S DI DMK7F9S DMK7F9S DN Amitriptyline DMK7F9S MI DEPKLMQ DMK7F9S MN Cytochrome P450 2B6 (CYP2B6) DMK7F9S MT DME DMK7F9S MA Metabolism DMK7F9S RN Application of the relative activity factor approach in scaling from heterologously expressed cytochromes p450 to human liver microsomes: studies on amitriptyline as a model substrate. J Pharmacol Exp Ther. 2001 Apr;297(1):326-37. DMK7F9S RU https://www.ncbi.nlm.nih.gov/pubmed/?term=11259560 DMK7F9S DI DMK7F9S DMK7F9S DN Amitriptyline DMK7F9S MI DES5XRU DMK7F9S MN Cytochrome P450 2C8 (CYP2C8) DMK7F9S MT DME DMK7F9S MA Metabolism DMK7F9S RN The xenobiotic inhibitor profile of cytochrome P4502C8. Br J Clin Pharmacol. 2000 Dec;50(6):573-80. DMK7F9S RU https://www.ncbi.nlm.nih.gov/pubmed/?term=11136296 DMK7F9S DI DMK7F9S DMK7F9S DN Amitriptyline DMK7F9S MI DE5IED8 DMK7F9S MN Cytochrome P450 2C9 (CYP2C9) DMK7F9S MT DME DMK7F9S MA Metabolism DMK7F9S RN Cytochromes P450 mediating the N-demethylation of amitriptyline. Br J Clin Pharmacol. 1997 Feb;43(2):137-44. DMK7F9S RU https://www.ncbi.nlm.nih.gov/pubmed/?term=9131945 DMK7F9S DI DMK7F9S DMK7F9S DN Amitriptyline DMK7F9S MI DECB0K3 DMK7F9S MN Cytochrome P450 2D6 (CYP2D6) DMK7F9S MT DME DMK7F9S MA Metabolism DMK7F9S RN Bioactivation of the tricyclic antidepressant amitriptyline and its metabolite nortriptyline to arene oxide intermediates in human liver microsomes and recombinant P450s. Chem Biol Interact. 2008 May 9;173(1):59-67. DMK7F9S RU https://www.ncbi.nlm.nih.gov/pubmed/?term=18359012 DMK7F9S DI DMK7F9S DMK7F9S DN Amitriptyline DMK7F9S MI DEVDYN7 DMK7F9S MN Cytochrome P450 2E1 (CYP2E1) DMK7F9S MT DME DMK7F9S MA Metabolism DMK7F9S RN Five distinct human cytochromes mediate amitriptyline N-demethylation in vitro: dominance of CYP 2C19 and 3A4. J Clin Pharmacol. 1998 Feb;38(2):112-21. DMK7F9S RU https://www.ncbi.nlm.nih.gov/pubmed/?term=9549641 DMK7F9S DI DMK7F9S DMK7F9S DN Amitriptyline DMK7F9S MI DE4LYSA DMK7F9S MN Cytochrome P450 3A4 (CYP3A4) DMK7F9S MT DME DMK7F9S MA Metabolism DMK7F9S RN Bioactivation of the tricyclic antidepressant amitriptyline and its metabolite nortriptyline to arene oxide intermediates in human liver microsomes and recombinant P450s. Chem Biol Interact. 2008 May 9;173(1):59-67. DMK7F9S RU https://www.ncbi.nlm.nih.gov/pubmed/?term=18359012 DMK7F9S DI DMK7F9S DMK7F9S DN Amitriptyline DMK7F9S MI DEIBDNY DMK7F9S MN Cytochrome P450 3A5 (CYP3A5) DMK7F9S MT DME DMK7F9S MA Metabolism DMK7F9S RN Effects of cytochrome b(5) on drug oxidation activities of human cytochrome P450 (CYP) 3As: similarity of CYP3A5 with CYP3A4 but not CYP3A7. Biochem Pharmacol. 2003 Dec 15;66(12):2333-40. DMK7F9S RU https://www.ncbi.nlm.nih.gov/pubmed/?term=14637191 DMK7F9S DI DMK7F9S DMK7F9S DN Amitriptyline DMK7F9S MI DEGTFWK DMK7F9S MN Mephenytoin 4-hydroxylase (CYP2C19) DMK7F9S MT DME DMK7F9S MA Metabolism DMK7F9S RN A study on CYP2C19 and CYP2D6 polymorphic effects on pharmacokinetics and pharmacodynamics of amitriptyline in healthy Koreans. Clin Transl Sci. 2017 Mar;10(2):93-101. DMK7F9S RU https://www.ncbi.nlm.nih.gov/pubmed/?term=28296334 DMK7F9S DI DMK7F9S DMK7F9S DN Amitriptyline DMK7F9S MI TTAWNKZ DMK7F9S MN Norepinephrine transporter (NET) DMK7F9S MT DTT DMK7F9S MA Inhibitor DMK7F9S RN Treatment of comorbid pain with serotonin norepinephrine reuptake inhibitors. CNS Spectr. 2008 Jul;13(7 Suppl 11):22-6. DMK7F9S RU https://pubmed.ncbi.nlm.nih.gov/18622371 DMK7F9S DI DMK7F9S DMK7F9S DN Amitriptyline DMK7F9S MI DTUGYRD DMK7F9S MN P-glycoprotein 1 (ABCB1) DMK7F9S MT DTP DMK7F9S MA Substrate DMK7F9S RN Caco-2 permeability, P-glycoprotein transport ratios and brain penetration of heterocyclic drugs. Int J Pharm. 2003 Sep 16;263(1-2):113-22. DMK7F9S RU http://www.ncbi.nlm.nih.gov/pubmed/12954186 DMK7F9S DI DMK7F9S DMK7F9S DN Amitriptyline DMK7F9S MI TT3ROYC DMK7F9S MN Serotonin transporter (SERT) DMK7F9S MT DTT DMK7F9S MA Inhibitor DMK7F9S RN Treatment of comorbid pain with serotonin norepinephrine reuptake inhibitors. CNS Spectr. 2008 Jul;13(7 Suppl 11):22-6. DMK7F9S RU https://pubmed.ncbi.nlm.nih.gov/18622371 DMK7F9S DI DMK7F9S DMK7F9S DN Amitriptyline DMK7F9S MI DEYGVN4 DMK7F9S MN UDP-glucuronosyltransferase 1A1 (UGT1A1) DMK7F9S MT DME DMK7F9S MA Metabolism DMK7F9S RN Liquid chromatography-tandem mass spectrometry method for measurement of nicotine N-glucuronide: a marker for human UGT2B10 inhibition. J Pharm Biomed Anal. 2011 Jul 15;55(5):964-71. DMK7F9S RU https://www.ncbi.nlm.nih.gov/pubmed/?term=21497036 DM0DQM5 DI DM0DQM5 DM0DQM5 DN Amlexanox DM0DQM5 MI TT78R5H DM0DQM5 MN Heat shock protein 90 alpha (HSP90A) DM0DQM5 MT DTT DM0DQM5 MA Inhibitor DM0DQM5 RN Hsp90 is a direct target of the anti-allergic drugs disodium cromoglycate and amlexanox. Biochem J. 2003 Sep 1;374(Pt 2):433-41. DM0DQM5 RU https://pubmed.ncbi.nlm.nih.gov/12803546 DMBDAZV DI DMBDAZV DMBDAZV DN Amlodipine DMBDAZV MI DE4LYSA DMBDAZV MN Cytochrome P450 3A4 (CYP3A4) DMBDAZV MT DME DMBDAZV MA Metabolism DMBDAZV RN Amlodipine metabolism in human liver microsomes and roles of CYP3A4/5 in the dihydropyridine dehydrogenation. Drug Metab Dispos. 2014 Feb;42(2):245-9. DMBDAZV RU https://www.ncbi.nlm.nih.gov/pubmed/?term=24301608 DMBDAZV DI DMBDAZV DMBDAZV DN Amlodipine DMBDAZV MI TTFK1JQ DMBDAZV MN Voltage-gated calcium channel alpha-2/delta-1 (CACNA2D1) DMBDAZV MT DTT DMBDAZV MA Blocker DMBDAZV RN A first drug combination for the treatment of arterial hypertension with a calcium channel antagonist (amlodipine besylate) and an angiotensin receptor blocker (valsartan): Exforge. Rev Med Liege. 2007 Nov;62(11):688-94. DMBDAZV RU https://pubmed.ncbi.nlm.nih.gov/18217647 DMOEVK6 DI DMOEVK6 DMOEVK6 DN Ammonia DMOEVK6 MI DTU6IF7 DMOEVK6 MN Ammonium transporter Rh type B (SLC42A2) DMOEVK6 MT DTP DMOEVK6 MA Substrate DMOEVK6 RN Functional analysis of human RhCG: comparison with E. coli ammonium transporter reveals similarities in the pore and differences in the vestibule. Am J Physiol Cell Physiol. 2009 Sep;297(3):C537-47. DMOEVK6 RU http://www.ncbi.nlm.nih.gov/pubmed/19553567 DMOEVK6 DI DMOEVK6 DMOEVK6 DN Ammonia DMOEVK6 MI DTF3LTV DMOEVK6 MN Ammonium transporter Rh type C (SLC42A3) DMOEVK6 MT DTP DMOEVK6 MA Substrate DMOEVK6 RN Functional analysis of human RhCG: comparison with E. coli ammonium transporter reveals similarities in the pore and differences in the vestibule. Am J Physiol Cell Physiol. 2009 Sep;297(3):C537-47. DMOEVK6 RU http://www.ncbi.nlm.nih.gov/pubmed/19553567 DMOEVK6 DI DMOEVK6 DMOEVK6 DN Ammonia DMOEVK6 MI DE5UC73 DMOEVK6 MN Glutamine synthetase (GLUL) DMOEVK6 MT DME DMOEVK6 MA Metabolism DMOEVK6 RN Ammonia metabolism capacity of HepG2 cells with high expression of human glutamine synthetase. Hepatobiliary Pancreat Dis Int. 2008 Dec;7(6):621-7. DMOEVK6 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=19073408 DM0GQ8N DI DM0GQ8N DM0GQ8N DN Amobarbital DM0GQ8N MI TT1MPAY DM0GQ8N MN GABA(A) receptor alpha-1 (GABRA1) DM0GQ8N MT DTT DM0GQ8N MA Antagonist DM0GQ8N RN DrugBank: a knowledgebase for drugs, drug actions and drug targets. Nucleic Acids Res. 2008 Jan;36(Database issue):D901-6. DM0GQ8N RU https://pubmed.ncbi.nlm.nih.gov/18048412 DME4RA8 DI DME4RA8 DME4RA8 DN Amodiaquine DME4RA8 MI DE4OGUF DME4RA8 MN Cytochrome P450 102A1 (cyp102) DME4RA8 MT DME DME4RA8 MA Metabolism DME4RA8 RN The bacterial P450 BM3: a prototype for a biocatalyst with human P450 activities. Trends Biotechnol. 2007 Jul;25(7):289-98. DME4RA8 RU https://pubmed.ncbi.nlm.nih.gov/17532492 DME4RA8 DI DME4RA8 DME4RA8 DN Amodiaquine DME4RA8 MI DE6OQ3W DME4RA8 MN Cytochrome P450 1A1 (CYP1A1) DME4RA8 MT DME DME4RA8 MA Metabolism DME4RA8 RN Amodiaquine clearance and its metabolism to N-desethylamodiaquine is mediated by CYP2C8: a new high affinity and turnover enzyme-specific probe substrate. J Pharmacol Exp Ther. 2002 Feb;300(2):399-407. DME4RA8 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=11805197 DME4RA8 DI DME4RA8 DME4RA8 DN Amodiaquine DME4RA8 MI DE9QHP6 DME4RA8 MN Cytochrome P450 1B1 (CYP1B1) DME4RA8 MT DME DME4RA8 MA Metabolism DME4RA8 RN Amodiaquine clearance and its metabolism to N-desethylamodiaquine is mediated by CYP2C8: a new high affinity and turnover enzyme-specific probe substrate. J Pharmacol Exp Ther. 2002 Feb;300(2):399-407. DME4RA8 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=11805197 DME4RA8 DI DME4RA8 DME4RA8 DN Amodiaquine DME4RA8 MI DES5XRU DME4RA8 MN Cytochrome P450 2C8 (CYP2C8) DME4RA8 MT DME DME4RA8 MA Metabolism DME4RA8 RN Amodiaquine metabolism is impaired by common polymorphisms in CYP2C8: implications for malaria treatment in Africa. Clin Pharmacol Ther. 2007 Aug;82(2):197-203. DME4RA8 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=17361129 DME4RA8 DI DME4RA8 DME4RA8 DN Amodiaquine DME4RA8 MI DERQ52Z DME4RA8 MN Glutathione S-transferase mu-4 (GSTM4) DME4RA8 MT DME DME4RA8 MA Metabolism DME4RA8 RN Human glutathione S-transferases- and NAD(P)H:quinone oxidoreductase 1-catalyzed inactivation of reactive quinoneimines of amodiaquine and N-desethylamodiaquine: possible implications for susceptibility to amodiaquine-induced liver toxicity. Toxicol Lett. 2017 Jun 5;275:83-91. DME4RA8 RU https://pubmed.ncbi.nlm.nih.gov/28478157 DME4RA8 DI DME4RA8 DME4RA8 DN Amodiaquine DME4RA8 MI TT2B6EV DME4RA8 MN Histamine N-methyltransferase (HNMT) DME4RA8 MT DTT DME4RA8 MA Inhibitor DME4RA8 RN Effect of amodiaquine, a histamine N-methyltransferase inhibitor, on, Propionibacterium acnes and lipopolysaccharide-induced hepatitis in mice. Eur J Pharmacol. 2007 Mar 8;558(1-3):179-84. DME4RA8 RU https://pubmed.ncbi.nlm.nih.gov/17222819 DML8QSZ DI DML8QSZ DML8QSZ DN Amosulalol DML8QSZ MI TT2NUT5 DML8QSZ MN Adrenergic receptor alpha-2C (ADRA2C) DML8QSZ MT DTT DML8QSZ MA Modulator DML8QSZ RN Effects of amosulalol, a combined alpha 1- and beta-adrenoceptor-blocking agent, on ischemic myocardial energy metabolism in dogs. J Pharm Sci. 1993 Mar;82(3):291-5. DML8QSZ RU https://pubmed.ncbi.nlm.nih.gov/8095542 DML8QSZ DI DML8QSZ DML8QSZ DN Amosulalol DML8QSZ MI TTMXGCW DML8QSZ MN Adrenergic receptor beta-3 (ADRB3) DML8QSZ MT DTT DML8QSZ MA Modulator DML8QSZ RN Effects of amosulalol, a combined alpha 1- and beta-adrenoceptor-blocking agent, on ischemic myocardial energy metabolism in dogs. J Pharm Sci. 1993 Mar;82(3):291-5. DML8QSZ RU https://pubmed.ncbi.nlm.nih.gov/8095542 DMKITQE DI DMKITQE DMKITQE DN Amoxapine DMKITQE MI DECB0K3 DMKITQE MN Cytochrome P450 2D6 (CYP2D6) DMKITQE MT DME DMKITQE MA Metabolism DMKITQE RN Addition of amoxapine improves positive and negative symptoms in a patient with schizophrenia. Ther Adv Psychopharmacol. 2013 Dec;3(6):340-2. DMKITQE RU https://www.ncbi.nlm.nih.gov/pubmed/?term=24294487 DMKITQE DI DMKITQE DMKITQE DN Amoxapine DMKITQE MI TTAWNKZ DMKITQE MN Norepinephrine transporter (NET) DMKITQE MT DTT DMKITQE MA Inhibitor DMKITQE RN Effects of acute and chronic treatment with amoxapine and cericlamine on the sleep-wakefulness cycle in the rat. Neuropharmacology. 1994 Aug;33(8):1017-25. DMKITQE RU https://pubmed.ncbi.nlm.nih.gov/7845548 DMUYNEI DI DMUYNEI DMUYNEI DN Amoxicillin DMUYNEI MI TTXT4D5 DMUYNEI MN Bacterial Cell membrane (Bact CM) DMUYNEI MT DTT DMUYNEI MA Modulator DMUYNEI RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. DMUYNEI RU https://www.fda.gov/ DMUYNEI DI DMUYNEI DMUYNEI DN Amoxicillin DMUYNEI MI DED0TBR DMUYNEI MN Beta-lactamase (blaB) DMUYNEI MT DME DMUYNEI MA Metabolism DMUYNEI RN Major phenylpropanoid-derived metabolites in the human gut can arise from microbial fermentation of protein. Mol Nutr Food Res. 2013 Mar;57(3):523-35. DMUYNEI RU https://pubmed.ncbi.nlm.nih.gov/23349065 DMUYNEI DI DMUYNEI DMUYNEI DN Amoxicillin DMUYNEI MI DEX8KJO DMUYNEI MN Beta-lactamase (blaB) DMUYNEI MT DME DMUYNEI MA Metabolism DMUYNEI RN The prevalence of beta-lactamase producing bacteria in subgingival plaque and their sensitivity to Augmentin. Br J Oral Maxillofac Surg. 1990 Jun;28(3):180-4. DMUYNEI RU https://pubmed.ncbi.nlm.nih.gov/1983762 DMUYNEI DI DMUYNEI DMUYNEI DN Amoxicillin DMUYNEI MI DEAYSTX DMUYNEI MN Beta-lactamase (blaB) DMUYNEI MT DME DMUYNEI MA Metabolism DMUYNEI RN ACI-1 beta-lactamase is widespread across human gut microbiomes in Negativicutes due to transposons harboured by tailed prophages. Environ Microbiol. 2018 Jun;20(6):2288-2300. DMUYNEI RU https://pubmed.ncbi.nlm.nih.gov/30014616 DMUYNEI DI DMUYNEI DMUYNEI DN Amoxicillin DMUYNEI MI DERGEVU DMUYNEI MN Beta-lactamase (blaB) DMUYNEI MT DME DMUYNEI MA Metabolism DMUYNEI RN Beta-lactamase production and susceptibilities to amoxicillin, amoxicillin-clavulanate, ticarcillin, ticarcillin-clavulanate, cefoxitin, imipenem, and metronidazole of 320 non-Bacteroides fragilis Bacteroides isolates and 129 fusobacteria from 28 U.S. centers. Antimicrob Agents Chemother. 1990 Aug;34(8):1546-50. DMUYNEI RU https://pubmed.ncbi.nlm.nih.gov/2221864 DMUYNEI DI DMUYNEI DMUYNEI DN Amoxicillin DMUYNEI MI DEV0KWQ DMUYNEI MN Beta-lactamase (blaB) DMUYNEI MT DME DMUYNEI MA Metabolism DMUYNEI RN Detection and characterization of beta-lactamase genes in subgingival bacteria from patients with refractory periodontitis. FEMS Microbiol Lett. 2005 Jan 15;242(2):319-24. DMUYNEI RU https://pubmed.ncbi.nlm.nih.gov/15621454 DMUYNEI DI DMUYNEI DMUYNEI DN Amoxicillin DMUYNEI MI DEQMISO DMUYNEI MN Beta-lactamase (blaB) DMUYNEI MT DME DMUYNEI MA Metabolism DMUYNEI RN Beta-lactamase production and susceptibilities to amoxicillin, amoxicillin-clavulanate, ticarcillin, ticarcillin-clavulanate, cefoxitin, imipenem, and metronidazole of 320 non-Bacteroides fragilis Bacteroides isolates and 129 fusobacteria from 28 U.S. centers. Antimicrob Agents Chemother. 1990 Aug;34(8):1546-50. DMUYNEI RU https://pubmed.ncbi.nlm.nih.gov/2221864 DMUYNEI DI DMUYNEI DMUYNEI DN Amoxicillin DMUYNEI MI DEHFJ4G DMUYNEI MN Beta-lactamase (blaB) DMUYNEI MT DME DMUYNEI MA Metabolism DMUYNEI RN Beta-lactamase production and susceptibilities to amoxicillin, amoxicillin-clavulanate, ticarcillin, ticarcillin-clavulanate, cefoxitin, imipenem, and metronidazole of 320 non-Bacteroides fragilis Bacteroides isolates and 129 fusobacteria from 28 U.S. centers. Antimicrob Agents Chemother. 1990 Aug;34(8):1546-50. DMUYNEI RU https://pubmed.ncbi.nlm.nih.gov/2221864 DMUYNEI DI DMUYNEI DMUYNEI DN Amoxicillin DMUYNEI MI DEHPJRC DMUYNEI MN Beta-lactamase (blaB) DMUYNEI MT DME DMUYNEI MA Metabolism DMUYNEI RN Beta-lactamase production and susceptibilities to amoxicillin, amoxicillin-clavulanate, ticarcillin, ticarcillin-clavulanate, cefoxitin, imipenem, and metronidazole of 320 non-Bacteroides fragilis Bacteroides isolates and 129 fusobacteria from 28 U.S. centers. Antimicrob Agents Chemother. 1990 Aug;34(8):1546-50. DMUYNEI RU https://pubmed.ncbi.nlm.nih.gov/2221864 DMUYNEI DI DMUYNEI DMUYNEI DN Amoxicillin DMUYNEI MI DEITMS0 DMUYNEI MN Beta-lactamase (blaB) DMUYNEI MT DME DMUYNEI MA Metabolism DMUYNEI RN ACI-1 from Acidaminococcus fermentans: characterization of the first beta-lactamase in Anaerobic cocci. Antimicrob Agents Chemother. 2000 Nov;44(11):3144-9. DMUYNEI RU https://pubmed.ncbi.nlm.nih.gov/11036038 DMUYNEI DI DMUYNEI DMUYNEI DN Amoxicillin DMUYNEI MI DET9I1W DMUYNEI MN Beta-lactamase (blaB) DMUYNEI MT DME DMUYNEI MA Metabolism DMUYNEI RN Prevalence of antimicrobial resistance genes in Bacteroides spp. and Prevotella spp. Dutch clinical isolates. Clin Microbiol Infect. 2019 Sep;25(9):1156.e9-1156.e13. DMUYNEI RU https://pubmed.ncbi.nlm.nih.gov/30802650 DMUYNEI DI DMUYNEI DMUYNEI DN Amoxicillin DMUYNEI MI DE7IH52 DMUYNEI MN Beta-lactamase (blaB) DMUYNEI MT DME DMUYNEI MA Metabolism DMUYNEI RN Detection and characterization of beta-lactamase genes in subgingival bacteria from patients with refractory periodontitis. FEMS Microbiol Lett. 2005 Jan 15;242(2):319-24. DMUYNEI RU https://pubmed.ncbi.nlm.nih.gov/15621454 DMUYNEI DI DMUYNEI DMUYNEI DN Amoxicillin DMUYNEI MI DENJ2SQ DMUYNEI MN Beta-lactamase (blaB) DMUYNEI MT DME DMUYNEI MA Metabolism DMUYNEI RN Prevalence of antimicrobial resistance genes in Bacteroides spp. and Prevotella spp. Dutch clinical isolates. Clin Microbiol Infect. 2019 Sep;25(9):1156.e9-1156.e13. DMUYNEI RU https://pubmed.ncbi.nlm.nih.gov/30802650 DMUYNEI DI DMUYNEI DMUYNEI DN Amoxicillin DMUYNEI MI DE5HV8P DMUYNEI MN Beta-lactamase (blaB) DMUYNEI MT DME DMUYNEI MA Metabolism DMUYNEI RN Prevalence of antimicrobial resistance genes in Bacteroides spp. and Prevotella spp. Dutch clinical isolates. Clin Microbiol Infect. 2019 Sep;25(9):1156.e9-1156.e13. DMUYNEI RU https://pubmed.ncbi.nlm.nih.gov/30802650 DMUYNEI DI DMUYNEI DMUYNEI DN Amoxicillin DMUYNEI MI DE47ARF DMUYNEI MN Beta-lactamase (blaB) DMUYNEI MT DME DMUYNEI MA Metabolism DMUYNEI RN Presence of the cfxA gene in Bacteroides distasonis. Res Microbiol. 2003 Jun;154(5):369-74. DMUYNEI RU https://pubmed.ncbi.nlm.nih.gov/12837513 DMUYNEI DI DMUYNEI DMUYNEI DN Amoxicillin DMUYNEI MI DEG2PK9 DMUYNEI MN Beta-lactamase (blaB) DMUYNEI MT DME DMUYNEI MA Metabolism DMUYNEI RN Prevalence of antimicrobial resistance genes in Bacteroides spp. and Prevotella spp. Dutch clinical isolates. Clin Microbiol Infect. 2019 Sep;25(9):1156.e9-1156.e13. DMUYNEI RU https://pubmed.ncbi.nlm.nih.gov/30802650 DMUYNEI DI DMUYNEI DMUYNEI DN Amoxicillin DMUYNEI MI DEWHJ7A DMUYNEI MN Beta-lactamase (blaB) DMUYNEI MT DME DMUYNEI MA Metabolism DMUYNEI RN Prevalence of antimicrobial resistance genes in Bacteroides spp. and Prevotella spp. Dutch clinical isolates. Clin Microbiol Infect. 2019 Sep;25(9):1156.e9-1156.e13. DMUYNEI RU https://pubmed.ncbi.nlm.nih.gov/30802650 DMUYNEI DI DMUYNEI DMUYNEI DN Amoxicillin DMUYNEI MI DEU1RXB DMUYNEI MN Beta-lactamase (blaB) DMUYNEI MT DME DMUYNEI MA Metabolism DMUYNEI RN Prevalence of antimicrobial resistance genes in Bacteroides spp. and Prevotella spp. Dutch clinical isolates. Clin Microbiol Infect. 2019 Sep;25(9):1156.e9-1156.e13. DMUYNEI RU https://pubmed.ncbi.nlm.nih.gov/30802650 DMUYNEI DI DMUYNEI DMUYNEI DN Amoxicillin DMUYNEI MI DETDS7E DMUYNEI MN Beta-lactamase (blaB) DMUYNEI MT DME DMUYNEI MA Metabolism DMUYNEI RN Detection and characterization of beta-lactamase genes in subgingival bacteria from patients with refractory periodontitis. FEMS Microbiol Lett. 2005 Jan 15;242(2):319-24. DMUYNEI RU https://pubmed.ncbi.nlm.nih.gov/15621454 DMUYNEI DI DMUYNEI DMUYNEI DN Amoxicillin DMUYNEI MI DE37FJH DMUYNEI MN Beta-lactamase (blaB) DMUYNEI MT DME DMUYNEI MA Metabolism DMUYNEI RN Beta-lactamase production and susceptibilities to amoxicillin, amoxicillin-clavulanate, ticarcillin, ticarcillin-clavulanate, cefoxitin, imipenem, and metronidazole of 320 non-Bacteroides fragilis Bacteroides isolates and 129 fusobacteria from 28 U.S. centers. Antimicrob Agents Chemother. 1990 Aug;34(8):1546-50. DMUYNEI RU https://pubmed.ncbi.nlm.nih.gov/2221864 DMUYNEI DI DMUYNEI DMUYNEI DN Amoxicillin DMUYNEI MI DEC7JEF DMUYNEI MN Beta-lactamase (blaB) DMUYNEI MT DME DMUYNEI MA Metabolism DMUYNEI RN Detection and characterization of beta-lactamase genes in subgingival bacteria from patients with refractory periodontitis. FEMS Microbiol Lett. 2005 Jan 15;242(2):319-24. DMUYNEI RU https://pubmed.ncbi.nlm.nih.gov/15621454 DMUYNEI DI DMUYNEI DMUYNEI DN Amoxicillin DMUYNEI MI DEP7MN1 DMUYNEI MN Beta-lactamase (blaB) DMUYNEI MT DME DMUYNEI MA Metabolism DMUYNEI RN Prevotella strains and lactamic resistance gene distribution in different oral environments of children with pulp necrosis. Int Endod J. 2018 Nov;51(11):1196-1204. DMUYNEI RU https://pubmed.ncbi.nlm.nih.gov/29737548 DMUYNEI DI DMUYNEI DMUYNEI DN Amoxicillin DMUYNEI MI DEAILCM DMUYNEI MN Beta-lactamase (blaB) DMUYNEI MT DME DMUYNEI MA Metabolism DMUYNEI RN Prevotella strains and lactamic resistance gene distribution in different oral environments of children with pulp necrosis. Int Endod J. 2018 Nov;51(11):1196-1204. DMUYNEI RU https://pubmed.ncbi.nlm.nih.gov/29737548 DMUYNEI DI DMUYNEI DMUYNEI DN Amoxicillin DMUYNEI MI DET4XFN DMUYNEI MN Beta-lactamase (blaB) DMUYNEI MT DME DMUYNEI MA Metabolism DMUYNEI RN Detection and characterization of beta-lactamase genes in subgingival bacteria from patients with refractory periodontitis. FEMS Microbiol Lett. 2005 Jan 15;242(2):319-24. DMUYNEI RU https://pubmed.ncbi.nlm.nih.gov/15621454 DMUYNEI DI DMUYNEI DMUYNEI DN Amoxicillin DMUYNEI MI DEACNTL DMUYNEI MN Beta-lactamase (blaB) DMUYNEI MT DME DMUYNEI MA Metabolism DMUYNEI RN IncU plasmid harbouring bla CTX-M-8 in multidrug-resistant Shigella sonnei in Brazil. J Glob Antimicrob Resist. 2018 Sep;14:99-100. DMUYNEI RU https://pubmed.ncbi.nlm.nih.gov/29964206 DMUYNEI DI DMUYNEI DMUYNEI DN Amoxicillin DMUYNEI MI DEE8742 DMUYNEI MN Beta-lactamase (blaB) DMUYNEI MT DME DMUYNEI MA Metabolism DMUYNEI RN High prevalence of beta-lactam and macrolide resistance genes in human oral Capnocytophaga species. J Antimicrob Chemother. 2014 Feb;69(2):381-4. DMUYNEI RU https://pubmed.ncbi.nlm.nih.gov/24013195 DMUYNEI DI DMUYNEI DMUYNEI DN Amoxicillin DMUYNEI MI DEY09SU DMUYNEI MN Beta-lactamase (blaB) DMUYNEI MT DME DMUYNEI MA Metabolism DMUYNEI RN Detection and characterization of beta-lactamase genes in subgingival bacteria from patients with refractory periodontitis. FEMS Microbiol Lett. 2005 Jan 15;242(2):319-24. DMUYNEI RU https://pubmed.ncbi.nlm.nih.gov/15621454 DMUYNEI DI DMUYNEI DMUYNEI DN Amoxicillin DMUYNEI MI DEQLVCA DMUYNEI MN Beta-lactamase (blaB) DMUYNEI MT DME DMUYNEI MA Metabolism DMUYNEI RN Prevotella strains and lactamic resistance gene distribution in different oral environments of children with pulp necrosis. Int Endod J. 2018 Nov;51(11):1196-1204. DMUYNEI RU https://pubmed.ncbi.nlm.nih.gov/29737548 DMUYNEI DI DMUYNEI DMUYNEI DN Amoxicillin DMUYNEI MI DE2IL34 DMUYNEI MN Beta-lactamase (blaB) DMUYNEI MT DME DMUYNEI MA Metabolism DMUYNEI RN High prevalence of beta-lactam and macrolide resistance genes in human oral Capnocytophaga species. J Antimicrob Chemother. 2014 Feb;69(2):381-4. DMUYNEI RU https://pubmed.ncbi.nlm.nih.gov/24013195 DMUYNEI DI DMUYNEI DMUYNEI DN Amoxicillin DMUYNEI MI DE1NJIW DMUYNEI MN Beta-lactamase (blaB) DMUYNEI MT DME DMUYNEI MA Metabolism DMUYNEI RN Yersinia enterocolitica and Photorhabdus asymbiotica beta-lactamases BlaA are exported by the twin-arginine translocation pathway. Int J Med Microbiol. 2013 Jan;303(1):16-24. DMUYNEI RU https://pubmed.ncbi.nlm.nih.gov/23276548 DMUYNEI DI DMUYNEI DMUYNEI DN Amoxicillin DMUYNEI MI DEDIMN9 DMUYNEI MN Beta-lactamase (blaB) DMUYNEI MT DME DMUYNEI MA Metabolism DMUYNEI RN Prevalence of antimicrobial resistance genes in Bacteroides spp. and Prevotella spp. Dutch clinical isolates. Clin Microbiol Infect. 2019 Sep;25(9):1156.e9-1156.e13. DMUYNEI RU https://pubmed.ncbi.nlm.nih.gov/30802650 DMUYNEI DI DMUYNEI DMUYNEI DN Amoxicillin DMUYNEI MI DEJ8X2W DMUYNEI MN Beta-lactamase (blaB) DMUYNEI MT DME DMUYNEI MA Metabolism DMUYNEI RN Prevalence of antimicrobial resistance genes in Bacteroides spp. and Prevotella spp. Dutch clinical isolates. Clin Microbiol Infect. 2019 Sep;25(9):1156.e9-1156.e13. DMUYNEI RU https://pubmed.ncbi.nlm.nih.gov/30802650 DMUYNEI DI DMUYNEI DMUYNEI DN Amoxicillin DMUYNEI MI DEFEVNH DMUYNEI MN Beta-lactamase (blaB) DMUYNEI MT DME DMUYNEI MA Metabolism DMUYNEI RN High prevalence of beta-lactam and macrolide resistance genes in human oral Capnocytophaga species. J Antimicrob Chemother. 2014 Feb;69(2):381-4. DMUYNEI RU https://pubmed.ncbi.nlm.nih.gov/24013195 DMUYNEI DI DMUYNEI DMUYNEI DN Amoxicillin DMUYNEI MI DEAPGXV DMUYNEI MN Beta-lactamase (blaB) DMUYNEI MT DME DMUYNEI MA Metabolism DMUYNEI RN Detection and characterization of beta-lactamase genes in subgingival bacteria from patients with refractory periodontitis. FEMS Microbiol Lett. 2005 Jan 15;242(2):319-24. DMUYNEI RU https://pubmed.ncbi.nlm.nih.gov/15621454 DMUYNEI DI DMUYNEI DMUYNEI DN Amoxicillin DMUYNEI MI DE0PDVC DMUYNEI MN Beta-lactamase (blaB) DMUYNEI MT DME DMUYNEI MA Metabolism DMUYNEI RN High prevalence of beta-lactam and macrolide resistance genes in human oral Capnocytophaga species. J Antimicrob Chemother. 2014 Feb;69(2):381-4. DMUYNEI RU https://pubmed.ncbi.nlm.nih.gov/24013195 DMUYNEI DI DMUYNEI DMUYNEI DN Amoxicillin DMUYNEI MI DEQL32N DMUYNEI MN Beta-lactamase (blaB) DMUYNEI MT DME DMUYNEI MA Metabolism DMUYNEI RN High prevalence of beta-lactam and macrolide resistance genes in human oral Capnocytophaga species. J Antimicrob Chemother. 2014 Feb;69(2):381-4. DMUYNEI RU https://pubmed.ncbi.nlm.nih.gov/24013195 DMUYNEI DI DMUYNEI DMUYNEI DN Amoxicillin DMUYNEI MI DE9HF0I DMUYNEI MN Beta-lactamase (blaB) DMUYNEI MT DME DMUYNEI MA Metabolism DMUYNEI RN Prevalence of antimicrobial resistance genes in Bacteroides spp. and Prevotella spp. Dutch clinical isolates. Clin Microbiol Infect. 2019 Sep;25(9):1156.e9-1156.e13. DMUYNEI RU https://pubmed.ncbi.nlm.nih.gov/30802650 DMUYNEI DI DMUYNEI DMUYNEI DN Amoxicillin DMUYNEI MI DESHI6O DMUYNEI MN Beta-lactamase (blaB) DMUYNEI MT DME DMUYNEI MA Metabolism DMUYNEI RN Prevalence of antimicrobial resistance genes in Bacteroides spp. and Prevotella spp. Dutch clinical isolates. Clin Microbiol Infect. 2019 Sep;25(9):1156.e9-1156.e13. DMUYNEI RU https://pubmed.ncbi.nlm.nih.gov/30802650 DMUYNEI DI DMUYNEI DMUYNEI DN Amoxicillin DMUYNEI MI DEZS3N4 DMUYNEI MN Beta-lactamase (blaB) DMUYNEI MT DME DMUYNEI MA Metabolism DMUYNEI RN Detection and characterization of beta-lactamase genes in subgingival bacteria from patients with refractory periodontitis. FEMS Microbiol Lett. 2005 Jan 15;242(2):319-24. DMUYNEI RU https://pubmed.ncbi.nlm.nih.gov/15621454 DMUYNEI DI DMUYNEI DMUYNEI DN Amoxicillin DMUYNEI MI DE5NSUX DMUYNEI MN Beta-lactamase (blaB) DMUYNEI MT DME DMUYNEI MA Metabolism DMUYNEI RN Detection and characterization of beta-lactamase genes in subgingival bacteria from patients with refractory periodontitis. FEMS Microbiol Lett. 2005 Jan 15;242(2):319-24. DMUYNEI RU https://pubmed.ncbi.nlm.nih.gov/15621454 DMUYNEI DI DMUYNEI DMUYNEI DN Amoxicillin DMUYNEI MI DEW193R DMUYNEI MN Beta-lactamase (blaB) DMUYNEI MT DME DMUYNEI MA Metabolism DMUYNEI RN Interspecies dissemination of a mobilizable plasmid harboring blaIMP-19 and the possibility of horizontal gene transfer in a single patient. Antimicrob Agents Chemother. 2016 Aug 22;60(9):5412-9. DMUYNEI RU https://pubmed.ncbi.nlm.nih.gov/27381397 DMUYNEI DI DMUYNEI DMUYNEI DN Amoxicillin DMUYNEI MI DEQ1CTE DMUYNEI MN Beta-lactamase (blaB) DMUYNEI MT DME DMUYNEI MA Metabolism DMUYNEI RN High prevalence of cfxA beta-lactamase in aminopenicillin-resistant Prevotella strains isolated from periodontal pockets. Oral Microbiol Immunol. 2002 Apr;17(2):85-8. DMUYNEI RU https://pubmed.ncbi.nlm.nih.gov/11929554 DMUYNEI DI DMUYNEI DMUYNEI DN Amoxicillin DMUYNEI MI DEGTFWK DMUYNEI MN Mephenytoin 4-hydroxylase (CYP2C19) DMUYNEI MT DME DMUYNEI MA Metabolism DMUYNEI RN High-dose rabeprazole/amoxicillin therapy as the second-line regimen after failure to eradicate H. pylori by triple therapy with the usual doses of a proton pump inhibitor, clarithromycin and amoxicillin. Hepatogastroenterology. 2003 Nov-Dec;50(54):2274-8. DMUYNEI RU https://www.ncbi.nlm.nih.gov/pubmed/?term=14696516 DMUYNEI DI DMUYNEI DMUYNEI DN Amoxicillin DMUYNEI MI DEPCQ12 DMUYNEI MN Metallo-beta-lactamase (blaM) DMUYNEI MT DME DMUYNEI MA Metabolism DMUYNEI RN Interspecies dissemination of a mobilizable plasmid harboring blaIMP-19 and the possibility of horizontal gene transfer in a single patient. Antimicrob Agents Chemother. 2016 Aug 22;60(9):5412-9. DMUYNEI RU https://pubmed.ncbi.nlm.nih.gov/27381397 DMUYNEI DI DMUYNEI DMUYNEI DN Amoxicillin DMUYNEI MI DEK9VG2 DMUYNEI MN Metallo-beta-lactamase (blaM) DMUYNEI MT DME DMUYNEI MA Metabolism DMUYNEI RN Interspecies dissemination of a mobilizable plasmid harboring blaIMP-19 and the possibility of horizontal gene transfer in a single patient. Antimicrob Agents Chemother. 2016 Aug 22;60(9):5412-9. DMUYNEI RU https://pubmed.ncbi.nlm.nih.gov/27381397 DMUYNEI DI DMUYNEI DMUYNEI DN Amoxicillin DMUYNEI MI DEIU0XN DMUYNEI MN N-acylhomoserine lactone acylase (lacA) DMUYNEI MT DME DMUYNEI MA Metabolism DMUYNEI RN A novel quorum-quenching N-acylhomoserine lactone acylase from Acidovorax sp. strain MR-S7 mediates antibiotic resistance. Appl Environ Microbiol. 2017 Jun 16;83(13). pii: e00080-17. DMUYNEI RU https://pubmed.ncbi.nlm.nih.gov/28455333 DMUYNEI DI DMUYNEI DMUYNEI DN Amoxicillin DMUYNEI MI DEBGCYQ DMUYNEI MN New delhi metallo-beta-lactamase NDM-1 (blaNDM) DMUYNEI MT DME DMUYNEI MA Metabolism DMUYNEI RN Genomic characterization of an extensively-drug resistance Salmonella enterica serotype Indiana strain harboring bla NDM-1 gene isolated from a chicken carcass in China. Microbiol Res. 2017 Nov;204:48-54. DMUYNEI RU https://pubmed.ncbi.nlm.nih.gov/28870291 DMUYNEI DI DMUYNEI DMUYNEI DN Amoxicillin DMUYNEI MI DTQ23VB DMUYNEI MN Organic anion transporter 1 (SLC22A6) DMUYNEI MT DTP DMUYNEI MA Substrate DMUYNEI RN The anti-influenza drug oseltamivir exhibits low potential to induce pharmacokinetic drug interactions via renal secretion-correlation of in vivo and in vitro studies. Drug Metab Dispos. 2002 Jan;30(1):13-9. DMUYNEI RU http://www.ncbi.nlm.nih.gov/pubmed/11744606 DMUYNEI DI DMUYNEI DMUYNEI DN Amoxicillin DMUYNEI MI DT9G7XN DMUYNEI MN Peptide transporter 1 (SLC15A1) DMUYNEI MT DTP DMUYNEI MA Substrate DMUYNEI RN Interactions of amoxicillin and cefaclor with human renal organic anion and peptide transporters. Drug Metab Dispos. 2006 Apr;34(4):547-55. DMUYNEI RU http://www.ncbi.nlm.nih.gov/pubmed/16434549 DMUYNEI DI DMUYNEI DMUYNEI DN Amoxicillin DMUYNEI MI DT8QKNP DMUYNEI MN Peptide transporter 2 (SLC15A2) DMUYNEI MT DTP DMUYNEI MA Substrate DMUYNEI RN Interactions of amoxicillin and cefaclor with human renal organic anion and peptide transporters. Drug Metab Dispos. 2006 Apr;34(4):547-55. DMUYNEI RU http://www.ncbi.nlm.nih.gov/pubmed/16434549 DMUYNEI DI DMUYNEI DMUYNEI DN Amoxicillin DMUYNEI MI DTUGYRD DMUYNEI MN P-glycoprotein 1 (ABCB1) DMUYNEI MT DTP DMUYNEI MA Substrate DMUYNEI RN Human intestinal transporter database: QSAR modeling and virtual profiling of drug uptake, efflux and interactions. Pharm Res. 2013 Apr;30(4):996-1007. DMUYNEI RU https://doi.org/10.1007/s11095-012-0935-x DMSZQAK DI DMSZQAK DMSZQAK DN Amphetamine DMSZQAK MI DECB0K3 DMSZQAK MN Cytochrome P450 2D6 (CYP2D6) DMSZQAK MT DME DMSZQAK MA Metabolism DMSZQAK RN Involvement of CYP2D6 in the in vitro metabolism of amphetamine, two N-alkylamphetamines and their 4-methoxylated derivatives. Xenobiotica. 1999 Jul;29(7):719-32. DMSZQAK RU https://www.ncbi.nlm.nih.gov/pubmed/?term=10456690 DMSZQAK DI DMSZQAK DMSZQAK DN Amphetamine DMSZQAK MI DT6201N DMSZQAK MN Organic cation transporter 3 (SLC22A3) DMSZQAK MT DTP DMSZQAK MA Substrate DMSZQAK RN Interaction of organic cation transporter 3 (SLC22A3) and amphetamine. J Neurochem. 2010 Jul;114(1):142-9. DMSZQAK RU http://www.ncbi.nlm.nih.gov/pubmed/20402963 DMSZQAK DI DMSZQAK DMSZQAK DN Amphetamine DMSZQAK MI DT3HUVD DMSZQAK MN Organic cation/carnitine transporter 2 (SLC22A5) DMSZQAK MT DTP DMSZQAK MA Substrate DMSZQAK RN Novel organic cation transporter 2-mediated carnitine uptake in placental choriocarcinoma (BeWo) cells. J Pharmacol Exp Ther. 2005 Jan;312(1):192-8. DMSZQAK RU http://www.ncbi.nlm.nih.gov/pubmed/15316089 DMSZQAK DI DMSZQAK DMSZQAK DN Amphetamine DMSZQAK MI DT3BA8L DMSZQAK MN Sodium-dependent dopamine transporter (SLC6A3) DMSZQAK MT DTP DMSZQAK MA Substrate DMSZQAK RN Amphetamines, new psychoactive drugs and the monoamine transporter cycle. Trends Pharmacol Sci. 2015 Jan;36(1):41-50. DMSZQAK RU http://www.ncbi.nlm.nih.gov/pubmed/25542076 DMSZQAK DI DMSZQAK DMSZQAK DN Amphetamine DMSZQAK MI DT9JBVI DMSZQAK MN Sodium-dependent noradrenaline transporter (SLC6A2) DMSZQAK MT DTP DMSZQAK MA Substrate DMSZQAK RN Amphetamines, new psychoactive drugs and the monoamine transporter cycle. Trends Pharmacol Sci. 2015 Jan;36(1):41-50. DMSZQAK RU http://www.ncbi.nlm.nih.gov/pubmed/25542076 DMSZQAK DI DMSZQAK DMSZQAK DN Amphetamine DMSZQAK MI TTIU98M DMSZQAK MN Trace amine-associated receptor-1 (TAAR1) DMSZQAK MT DTT DMSZQAK MA Modulator DMSZQAK RN Methamphetamine and HIV-1-induced neurotoxicity: role of trace amine associated receptor 1 cAMP signaling in astrocytes. Neuropharmacology. 2014 Oct;85:499-507. DMSZQAK RU https://pubmed.ncbi.nlm.nih.gov/24950453 DMSZQAK DI DMSZQAK DMSZQAK DN Amphetamine DMSZQAK MI DEB3TNR DMSZQAK MN Tyramine oxidase (tynA) DMSZQAK MT DME DMSZQAK MA Metabolism DMSZQAK RN Mechanistic elucidation of amphetamine metabolism by tyramine oxidase from human gut microbiota using molecular dynamics simulations. J Cell Biochem. 2019 Jan 30. DMSZQAK RU https://pubmed.ncbi.nlm.nih.gov/30701587 DMTAJQE DI DMTAJQE DMTAJQE DN Amphotericin B DMTAJQE MI TTQKWA4 DMTAJQE MN Fungal Cell membrane ergosterol (Fung CME) DMTAJQE MT DTT DMTAJQE MA Modulator DMTAJQE RN Comparative molecular dynamics simulations of amphotericin B-cholesterol/ergosterol membrane channels. Biochim Biophys Acta. 2002 Dec 23;1567(1-2):63-78. DMTAJQE RU https://pubmed.ncbi.nlm.nih.gov/12488039 DMTAJQE DI DMTAJQE DMTAJQE DN Amphotericin B DMTAJQE MI DTUGYRD DMTAJQE MN P-glycoprotein 1 (ABCB1) DMTAJQE MT DTP DMTAJQE MA Substrate DMTAJQE RN Carotenoids reverse multidrug resistance in cancer cells by interfering with ABC-transporters. Phytomedicine. 2012 Aug 15;19(11):977-87. DMTAJQE RU https://doi.org/10.1016/j.phymed.2012.05.010 DMHWE7P DI DMHWE7P DMHWE7P DN Ampicillin DMHWE7P MI DERI7LO DMHWE7P MN AmpC beta-lactamase (ampC) DMHWE7P MT DME DMHWE7P MA Metabolism DMHWE7P RN Characterization of the AmpC beta-Lactamase from Burkholderia multivorans. Antimicrob Agents Chemother. 2018 Sep 24;62(10). pii: e01140-18. DMHWE7P RU https://pubmed.ncbi.nlm.nih.gov/30012762 DMHWE7P DI DMHWE7P DMHWE7P DN Ampicillin DMHWE7P MI TTJP4SM DMHWE7P MN Bacterial Penicillin binding protein (Bact PBP) DMHWE7P MT DTT DMHWE7P MA Binder DMHWE7P RN Effects of amino acid alterations in penicillin-binding proteins (PBPs) 1a, 2b, and 2x on PBP affinities of penicillin, ampicillin, amoxicillin, cefditoren, cefuroxime, cefprozil, and cefaclor in 18 clinical isolates of penicillin-susceptible, -intermediate, and -resistant pneumococci. Antimicrob Agents Chemother. 2002 May;46(5):1273-80. DMHWE7P RU https://pubmed.ncbi.nlm.nih.gov/11959556 DMHWE7P DI DMHWE7P DMHWE7P DN Ampicillin DMHWE7P MI DET9I1W DMHWE7P MN Beta-lactamase (blaB) DMHWE7P MT DME DMHWE7P MA Metabolism DMHWE7P RN Purification and characterization of a new beta-lactamase from Bacteroides uniformis. Antimicrob Agents Chemother. 1995 Jul;39(7):1458-61. DMHWE7P RU https://pubmed.ncbi.nlm.nih.gov/7492085 DMHWE7P DI DMHWE7P DMHWE7P DN Ampicillin DMHWE7P MI DE3FVRW DMHWE7P MN Beta-lactamase (blaB) DMHWE7P MT DME DMHWE7P MA Metabolism DMHWE7P RN Beta-lactamase production and antimicrobial susceptibility of subgingival bacteria from refractory periodontitis. Oral Microbiol Immunol. 2004 Oct;19(5):303-8. DMHWE7P RU https://pubmed.ncbi.nlm.nih.gov/15327642 DMHWE7P DI DMHWE7P DMHWE7P DN Ampicillin DMHWE7P MI DETDS7E DMHWE7P MN Beta-lactamase (blaB) DMHWE7P MT DME DMHWE7P MA Metabolism DMHWE7P RN Beta-lactamase production and antimicrobial susceptibility of subgingival bacteria from refractory periodontitis. Oral Microbiol Immunol. 2004 Oct;19(5):303-8. DMHWE7P RU https://pubmed.ncbi.nlm.nih.gov/15327642 DMHWE7P DI DMHWE7P DMHWE7P DN Ampicillin DMHWE7P MI DEQX0DG DMHWE7P MN Beta-lactamase (blaB) DMHWE7P MT DME DMHWE7P MA Metabolism DMHWE7P RN Beta-lactamase production and antimicrobial susceptibility of subgingival bacteria from refractory periodontitis. Oral Microbiol Immunol. 2004 Oct;19(5):303-8. DMHWE7P RU https://pubmed.ncbi.nlm.nih.gov/15327642 DMHWE7P DI DMHWE7P DMHWE7P DN Ampicillin DMHWE7P MI DEC7JEF DMHWE7P MN Beta-lactamase (blaB) DMHWE7P MT DME DMHWE7P MA Metabolism DMHWE7P RN Beta-lactamase production and antimicrobial susceptibility of subgingival bacteria from refractory periodontitis. Oral Microbiol Immunol. 2004 Oct;19(5):303-8. DMHWE7P RU https://pubmed.ncbi.nlm.nih.gov/15327642 DMHWE7P DI DMHWE7P DMHWE7P DN Ampicillin DMHWE7P MI DEXB2A9 DMHWE7P MN Beta-lactamase (blaB) DMHWE7P MT DME DMHWE7P MA Metabolism DMHWE7P RN Beta-lactamase expression in Plesiomonas shigelloides. J Antimicrob Chemother. 2000 Jun;45(6):877-80. DMHWE7P RU https://pubmed.ncbi.nlm.nih.gov/10837443 DMHWE7P DI DMHWE7P DMHWE7P DN Ampicillin DMHWE7P MI DEBKS91 DMHWE7P MN Beta-lactamase (blaB) DMHWE7P MT DME DMHWE7P MA Metabolism DMHWE7P RN Drug-resistant genes carried by Acinetobacter baumanii isolated from patients with lower respiratory tract infection. Chin Med J (Engl). 2010 Sep;123(18):2571-5. DMHWE7P RU https://pubmed.ncbi.nlm.nih.gov/21034630 DMHWE7P DI DMHWE7P DMHWE7P DN Ampicillin DMHWE7P MI DEWMGC3 DMHWE7P MN Beta-lactamase (blaB) DMHWE7P MT DME DMHWE7P MA Metabolism DMHWE7P RN Beta-lactamase production and antimicrobial susceptibility of subgingival bacteria from refractory periodontitis. Oral Microbiol Immunol. 2004 Oct;19(5):303-8. DMHWE7P RU https://pubmed.ncbi.nlm.nih.gov/15327642 DMHWE7P DI DMHWE7P DMHWE7P DN Ampicillin DMHWE7P MI DEWYT5M DMHWE7P MN Beta-lactamase (blaB) DMHWE7P MT DME DMHWE7P MA Metabolism DMHWE7P RN Beta-lactamase production and antimicrobial susceptibility of subgingival bacteria from refractory periodontitis. Oral Microbiol Immunol. 2004 Oct;19(5):303-8. DMHWE7P RU https://pubmed.ncbi.nlm.nih.gov/15327642 DMHWE7P DI DMHWE7P DMHWE7P DN Ampicillin DMHWE7P MI DE52KD0 DMHWE7P MN Beta-lactamase (blaB) DMHWE7P MT DME DMHWE7P MA Metabolism DMHWE7P RN Beta-lactamase production and antimicrobial susceptibility of subgingival bacteria from refractory periodontitis. Oral Microbiol Immunol. 2004 Oct;19(5):303-8. DMHWE7P RU https://pubmed.ncbi.nlm.nih.gov/15327642 DMHWE7P DI DMHWE7P DMHWE7P DN Ampicillin DMHWE7P MI DEG5Y4W DMHWE7P MN Beta-lactamase (blaB) DMHWE7P MT DME DMHWE7P MA Metabolism DMHWE7P RN Beta-lactamase production and antimicrobial susceptibility of subgingival bacteria from refractory periodontitis. Oral Microbiol Immunol. 2004 Oct;19(5):303-8. DMHWE7P RU https://pubmed.ncbi.nlm.nih.gov/15327642 DMHWE7P DI DMHWE7P DMHWE7P DN Ampicillin DMHWE7P MI DTFI42L DMHWE7P MN Multidrug resistance-associated protein 2 (ABCC2) DMHWE7P MT DTP DMHWE7P MA Substrate DMHWE7P RN Mammalian drug efflux transporters of the ATP binding cassette (ABC) family in multidrug resistance: A review of the past decade. Cancer Lett. 2016 Jan 1;370(1):153-64. 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DMHWE7P RU http://www.ncbi.nlm.nih.gov/pubmed/28214542 DMHWE7P DI DMHWE7P DMHWE7P DN Ampicillin DMHWE7P MI DT8QKNP DMHWE7P MN Peptide transporter 2 (SLC15A2) DMHWE7P MT DTP DMHWE7P MA Substrate DMHWE7P RN Transport characteristics of a novel peptide transporter 1 substrate, antihypotensive drug midodrine, and its amino acid derivatives. J Pharmacol Exp Ther. 2006 Jul;318(1):455-60. DMHWE7P RU http://www.ncbi.nlm.nih.gov/pubmed/16597710 DM5BS98 DI DM5BS98 DM5BS98 DN Ampiroxicam DM5BS98 MI TTK0943 DM5BS98 MN Prostaglandin G/H synthase (COX) DM5BS98 MT DTT DM5BS98 MA Modulator DM5BS98 RN Premedication with cyclooxygenase-2 inhibitor meloxicam reduced postoperative pain in patients after oral surgery. Int J Oral Maxillofac Surg. 2006 Jul;35(7):613-7. DM5BS98 RU https://pubmed.ncbi.nlm.nih.gov/16540287 DMLMXE0 DI DMLMXE0 DMLMXE0 DN Amprenavir DMLMXE0 MI DE5IED8 DMLMXE0 MN Cytochrome P450 2C9 (CYP2C9) DMLMXE0 MT DME DMLMXE0 MA Metabolism DMLMXE0 RN Amprenavir: a new human immunodeficiency virus type 1 protease inhibitor. Clin Ther. 2000 May;22(5):549-72. DMLMXE0 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=10868554 DMLMXE0 DI DMLMXE0 DMLMXE0 DN Amprenavir DMLMXE0 MI DECB0K3 DMLMXE0 MN Cytochrome P450 2D6 (CYP2D6) DMLMXE0 MT DME DMLMXE0 MA Metabolism DMLMXE0 RN Amprenavir: a new human immunodeficiency virus type 1 protease inhibitor. Clin Ther. 2000 May;22(5):549-72. DMLMXE0 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=10868554 DMLMXE0 DI DMLMXE0 DMLMXE0 DN Amprenavir DMLMXE0 MI DE4LYSA DMLMXE0 MN Cytochrome P450 3A4 (CYP3A4) DMLMXE0 MT DME DMLMXE0 MA Metabolism DMLMXE0 RN Differential inhibition of cytochrome P450 3A4, 3A5 and 3A7 by five human immunodeficiency virus (HIV) protease inhibitors in vitro. Basic Clin Pharmacol Toxicol. 2006 Jan;98(1):79-85. DMLMXE0 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=16433896 DMLMXE0 DI DMLMXE0 DMLMXE0 DN Amprenavir DMLMXE0 MI DEIBDNY DMLMXE0 MN Cytochrome P450 3A5 (CYP3A5) DMLMXE0 MT DME DMLMXE0 MA Metabolism DMLMXE0 RN Oxidative metabolism of amprenavir in the human liver. Effect of the CYP3A maturation. Drug Metab Dispos. 2003 Mar;31(3):275-81. DMLMXE0 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=12584153 DMLMXE0 DI DMLMXE0 DMLMXE0 DN Amprenavir DMLMXE0 MI TT5FNQT DMLMXE0 MN Human immunodeficiency virus Protease (HIV PR) DMLMXE0 MT DTT DMLMXE0 MA Inhibitor DMLMXE0 RN Darunavir: a review of its use in the management of HIV infection in adults. Drugs. 2009;69(4):477-503. DMLMXE0 RU https://pubmed.ncbi.nlm.nih.gov/19323590 DMLMXE0 DI DMLMXE0 DMLMXE0 DN Amprenavir DMLMXE0 MI DTUGYRD DMLMXE0 MN P-glycoprotein 1 (ABCB1) DMLMXE0 MT DTP DMLMXE0 MA Substrate DMLMXE0 RN Mammalian drug efflux transporters of the ATP binding cassette (ABC) family in multidrug resistance: A review of the past decade. Cancer Lett. 2016 Jan 1;370(1):153-64. DMLMXE0 RU http://www.ncbi.nlm.nih.gov/pubmed/26499806 DMZKYIV DI DMZKYIV DMZKYIV DN Amsacrine DMZKYIV MI DECB0K3 DMZKYIV MN Cytochrome P450 2D6 (CYP2D6) DMZKYIV MT DME DMZKYIV MA Metabolism DMZKYIV RN Phase I pharmacokinetic study of the novel antitumor agent SR233377. Clin Cancer Res. 2000 Aug;6(8):3088-94. DMZKYIV RU https://www.ncbi.nlm.nih.gov/pubmed/?term=10955788 DMZKYIV DI DMZKYIV DMZKYIV DN Amsacrine DMZKYIV MI TT0IHXV DMZKYIV MN DNA topoisomerase II (TOP2) DMZKYIV MT DTT DMZKYIV MA Inhibitor DMZKYIV RN Design of two etoposide-amsacrine conjugates: topoisomerase II and tubuline polymerization inhibition and relation to cytotoxicity. Anticancer Drug Des. 2000 Dec;15(6):413-21. DMZKYIV RU https://pubmed.ncbi.nlm.nih.gov/11716434 DMAWU35 DI DMAWU35 DMAWU35 DN Amtolmetin guacil DMAWU35 MI TTK0943 DMAWU35 MN Prostaglandin G/H synthase (COX) DMAWU35 MT DTT DMAWU35 MA Modulator DMAWU35 RN Gastrointestinal safety of amtolmetin guacyl in comparison with celecoxib in patients with rheumatoid arthritis. Clin Exp Rheumatol. 2005 Nov-Dec;23(6):809-18. DMAWU35 RU https://pubmed.ncbi.nlm.nih.gov/16396699 DMJKO05 DI DMJKO05 DMJKO05 DN Amyl nitrite DMJKO05 MI DEWYTJB DMJKO05 MN Aldehyde dehydrogenase 2 (ALDH2) DMJKO05 MT DME DMJKO05 MA Metabolism DMJKO05 RN Mitochondrial aldehyde dehydrogenase mediates vasodilator responses of glyceryl trinitrate and sodium nitrite in the pulmonary vascular bed of the rat. Am J Physiol Heart Circ Physiol. 2010 Sep;299(3):H819-26. DMJKO05 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=20543077 DMJKO05 DI DMJKO05 DMJKO05 DN Amyl nitrite DMJKO05 MI DE4ZHS1 DMJKO05 MN Glutathione S-transferase alpha-1 (GSTA1) DMJKO05 MT DME DMJKO05 MA Metabolism DMJKO05 RN Subunit specificity and organ distribution of glutathione transferase-catalysed S-nitrosoglutathione formation from alkyl nitrites in the rat. Biochem Pharmacol. 1997 Jan 10;53(1):117-20. 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DMV96ZH RU https://pubmed.ncbi.nlm.nih.gov/12220959 DMNP60F DI DMNP60F DMNP60F DN Anastrozole DMNP60F MI TTSZLWK DMNP60F MN Aromatase (CYP19A1) DMNP60F MT DTT DMNP60F MA Inhibitor DMNP60F RN Effective aromatase inhibition by anastrozole in a patient with gonadotropin-independent precocious puberty in McCune-Albright syndrome. J Pediatr Endocrinol Metab. 2002;15 Suppl 3:945-8. DMNP60F RU https://pubmed.ncbi.nlm.nih.gov/12199354 DMNP60F DI DMNP60F DMNP60F DN Anastrozole DMNP60F MI DES5XRU DMNP60F MN Cytochrome P450 2C8 (CYP2C8) DMNP60F MT DME DMNP60F MA Metabolism DMNP60F RN In vitro and in vivo oxidative metabolism and glucuronidation of anastrozole. Br J Clin Pharmacol. 2010 Dec;70(6):854-69. DMNP60F RU https://www.ncbi.nlm.nih.gov/pubmed/?term=21175441 DMNP60F DI DMNP60F DMNP60F DN Anastrozole DMNP60F MI DE4LYSA DMNP60F MN Cytochrome P450 3A4 (CYP3A4) DMNP60F MT DME DMNP60F MA Metabolism DMNP60F RN In vitro and in vivo oxidative metabolism and glucuronidation of anastrozole. 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DMNP60F RU http://www.ncbi.nlm.nih.gov/pubmed/30648747 DMNP60F DI DMNP60F DMNP60F DN Anastrozole DMNP60F MI DEYGVN4 DMNP60F MN UDP-glucuronosyltransferase 1A1 (UGT1A1) DMNP60F MT DME DMNP60F MA Metabolism DMNP60F RN In vitro and in vivo oxidative metabolism and glucuronidation of anastrozole. Br J Clin Pharmacol. 2010 Dec;70(6):854-69. DMNP60F RU https://www.ncbi.nlm.nih.gov/pubmed/?term=21175441 DMNP60F DI DMNP60F DMNP60F DN Anastrozole DMNP60F MI DEF2WXN DMNP60F MN UDP-glucuronosyltransferase 1A3 (UGT1A3) DMNP60F MT DME DMNP60F MA Metabolism DMNP60F RN In vitro and in vivo oxidative metabolism and glucuronidation of anastrozole. Br J Clin Pharmacol. 2010 Dec;70(6):854-69. DMNP60F RU https://www.ncbi.nlm.nih.gov/pubmed/?term=21175441 DMNP60F DI DMNP60F DMNP60F DN Anastrozole DMNP60F MI DEB3CV1 DMNP60F MN UDP-glucuronosyltransferase 2B7 (UGT2B7) DMNP60F MT DME DMNP60F MA Metabolism DMNP60F RN In vitro and in vivo oxidative metabolism and glucuronidation of anastrozole. Br J Clin Pharmacol. 2010 Dec;70(6):854-69. DMNP60F RU https://www.ncbi.nlm.nih.gov/pubmed/?term=21175441 DMLWQ27 DI DMLWQ27 DMLWQ27 DN Angiotensin Ii DMLWQ27 MI TT8DBY3 DMLWQ27 MN Angiotensin II receptor type-1 (AGTR1) DMLWQ27 MT DTT DMLWQ27 MA Inhibitor DMLWQ27 RN The amino-terminus of angiotensin II contacts several ectodomains of the angiotensin II receptor AT1. J Med Chem. 2010 Mar 11;53(5):2063-75. DMLWQ27 RU https://pubmed.ncbi.nlm.nih.gov/20146480 DMLWQ27 DI DMLWQ27 DMLWQ27 DN Angiotensin Ii DMLWQ27 MI TTQVOEI DMLWQ27 MN Angiotensin II receptor type-2 (AGTR2) DMLWQ27 MT DTT DMLWQ27 MA Inhibitor DMLWQ27 RN The preparation of (perfluoroalkyl)imidazoles as nonpeptide angiotensin II receptor antagonists, Bioorg. Med. Chem. Lett. 3(5):895-898 (1993). DMLWQ27 RU http://www.sciencedirect.com/science/article/pii/S0960894X00806885 DM8QM5U DI DM8QM5U DM8QM5U DN Anidulafungin DM8QM5U MI TT0SFXH DM8QM5U MN Fungal 1,3-beta-glucan synthase (Fung GSC2) DM8QM5U MT DTT DM8QM5U MA Modulator DM8QM5U RN 2006 drug approvals: finding the niche. Nat Rev Drug Discov. 2007 Feb;6(2):99-101. DM8QM5U RU https://pubmed.ncbi.nlm.nih.gov/17342860 DMBAUED DI DMBAUED DMBAUED DN Anileridine DMBAUED MI TTKWM86 DMBAUED MN Opioid receptor mu (MOP) DMBAUED MT DTT DMBAUED MA Agonist DMBAUED RN Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. DMBAUED RU https://pubmed.ncbi.nlm.nih.gov/17016423 DMC128O DI DMC128O DMC128O DN Anileridine Hydrochloride DMC128O MI TTKWM86 DMC128O MN Opioid receptor mu (MOP) DMC128O MT DTT DMC128O MA Modulator DMC128O RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. DMC128O RU https://www.fda.gov/ DMOIFW0 DI DMOIFW0 DMOIFW0 DN Aniracetam DMOIFW0 MI TTJQOD7 DMOIFW0 MN 5-HT 2A receptor (HTR2A) DMOIFW0 MT DTT DMOIFW0 MA Inhibitor DMOIFW0 RN Anxiolytic effects of aniracetam in three different mouse models of anxiety and the underlying mechanism. Eur J Pharmacol. 2001 May 18;420(1):33-43. DMOIFW0 RU https://pubmed.ncbi.nlm.nih.gov/11412837 DMOIFW0 DI DMOIFW0 DMOIFW0 DN Aniracetam DMOIFW0 MI TTEX248 DMOIFW0 MN Dopamine D2 receptor (D2R) DMOIFW0 MT DTT DMOIFW0 MA Inhibitor DMOIFW0 RN Anxiolytic effects of aniracetam in three different mouse models of anxiety and the underlying mechanism. Eur J Pharmacol. 2001 May 18;420(1):33-43. DMOIFW0 RU https://pubmed.ncbi.nlm.nih.gov/11412837 DM2C48U DI DM2C48U DM2C48U DN Anisindione DM2C48U MI TT6L509 DM2C48U MN Coagulation factor IIa (F2) DM2C48U MT DTT DM2C48U MA Modulator DM2C48U RN Anticoagulation with anisindione in a patient with a warfarin-induced skin eruption. Pharmacotherapy. 2003 Apr;23(4):533-6. DM2C48U RU https://pubmed.ncbi.nlm.nih.gov/12680483 DMW51AX DI DMW51AX DMW51AX DN Anisodamine DMW51AX MI TTR6W5O DMW51AX MN Adrenergic receptor beta-1 (ADRB1) DMW51AX MT DTT DMW51AX MA Modulator DMW51AX RN Medicinal plants in therapy. Bull World Health Organ. 1985;63(6):965-81. DMW51AX RU https://pubmed.ncbi.nlm.nih.gov/3879679 DMW51AX DI DMW51AX DMW51AX DN Anisodamine DMW51AX MI DECB0K3 DMW51AX MN Cytochrome P450 2D6 (CYP2D6) DMW51AX MT DME DMW51AX MA Metabolism DMW51AX RN Application of substrate depletion assay to evaluation of CYP isoforms responsible for stereoselective metabolism of carvedilol. Drug Metab Pharmacokinet. 2016 Dec;31(6):425-432. DMW51AX RU https://www.ncbi.nlm.nih.gov/pubmed/?term=27836712 DMNOSWU DI DMNOSWU DMNOSWU DN Anisodine DMNOSWU MI TTR6W5O DMNOSWU MN Adrenergic receptor beta-1 (ADRB1) DMNOSWU MT DTT DMNOSWU MA Modulator DMNOSWU RN Medicinal plants in therapy. Bull World Health Organ. 1985;63(6):965-81. DMNOSWU RU https://pubmed.ncbi.nlm.nih.gov/3879679 DMNOSWU DI DMNOSWU DMNOSWU DN Anisodine DMNOSWU MI TTH18TF DMNOSWU MN Muscarinic acetylcholine receptor M5 (CHRM5) DMNOSWU MT DTT DMNOSWU MA Modulator DMNOSWU RN Medicinal plants in therapy. Bull World Health Organ. 1985;63(6):965-81. DMNOSWU RU https://pubmed.ncbi.nlm.nih.gov/3879679 DMIJRF0 DI DMIJRF0 DMIJRF0 DN Anisotropine Methylbromide DMIJRF0 MI TTH18TF DMIJRF0 MN Muscarinic acetylcholine receptor M5 (CHRM5) DMIJRF0 MT DTT DMIJRF0 MA Binder DMIJRF0 RN Anisotropine methylbromide: a new antispasmodic for gastrointestinal disorders. Curr Ther Res Clin Exp. 1963 May;5:213-8. DMIJRF0 RU https://pubmed.ncbi.nlm.nih.gov/13966843 DM6Q4B0 DI DM6Q4B0 DM6Q4B0 DN Anistreplase DM6Q4B0 MI TTP86E2 DM6Q4B0 MN Plasminogen (PLG) DM6Q4B0 MT DTT DM6Q4B0 MA Activator DM6Q4B0 RN Evaluation of thrombolytic agents. Drugs. 1997;54 Suppl 3:11-6; discussion 16-7. DM6Q4B0 RU https://pubmed.ncbi.nlm.nih.gov/9360848 DMUMOEV DI DMUMOEV DMUMOEV DN Ansuvimab DMUMOEV MI TT2F0AU DMUMOEV MN Ebola virus Envelope glycoprotein (EV GP) DMUMOEV MT DTT DMUMOEV RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health Human Services. 2020 DMUMOEV RU https://www.accessdata.fda.gov/drugsatfda_docs/label/2020/761172s000lbl.pdf DMA04JS DI DMA04JS DMA04JS DN Antazoline DMA04JS MI TTTIBOJ DMA04JS MN Histamine H1 receptor (H1R) DMA04JS MT DTT DMA04JS MA Antagonist DMA04JS RN Histamine and the convulsive threshold or effectiveness of antiepileptic drugs. Przegl Lek. 2008;65(11):803-6. DMA04JS RU https://pubmed.ncbi.nlm.nih.gov/19205365 DMNC64R DI DMNC64R DMNC64R DN Antegren DMNC64R MI TT4BT06 DMNC64R MN Integrin alpha-4 (ITGA4) DMNC64R MT DTT DMNC64R RN Very late antigen 4 (VLA4) antagonists as anti-inflammatory agents. Curr Opin Chem Biol. 1998 Aug;2(4):453-7. DMNC64R RU https://pubmed.ncbi.nlm.nih.gov/9736917 DMH4CFE DI DMH4CFE DMH4CFE DN Antithymocyte globulin DMH4CFE MI TTBGTFN DMH4CFE MN T-cell surface glycoprotein CD1a (CD1A) DMH4CFE MT DTT DMH4CFE MA Binder DMH4CFE RN Acute sensory neuropathy associated with rabbit antithymocyte globulin. Am J Transplant. 2007 Feb;7(2):484-6. DMH4CFE RU https://pubmed.ncbi.nlm.nih.gov/17283492 DM89JLN DI DM89JLN DM89JLN DN Apixaban DM89JLN MI DTI7UX6 DM89JLN MN Breast cancer resistance protein (ABCG2) DM89JLN MT DTP DM89JLN MA Substrate DM89JLN RN Characterization of efflux transporters involved in distribution and disposition of apixaban. Drug Metab Dispos. 2013 Apr;41(4):827-35. DM89JLN RU http://www.ncbi.nlm.nih.gov/pubmed/23382458 DM89JLN DI DM89JLN DM89JLN DN Apixaban DM89JLN MI TTCIHJA DM89JLN MN Coagulation factor Xa (F10) DM89JLN MT DTT DM89JLN MA Inhibitor DM89JLN RN Pfizer. Product Development Pipeline. March 31 2009. DM89JLN RU http://media.pfizer.com/files/research/pipeline/2009_0331/pipeline_2009_0331.pdf DM89JLN DI DM89JLN DM89JLN DN Apixaban DM89JLN MI DEJGDUW DM89JLN MN Cytochrome P450 1A2 (CYP1A2) DM89JLN MT DME DM89JLN MA Metabolism DM89JLN RN Apixaban. Hosp Pharm. 2013 Jun;48(6):494-509. DM89JLN RU https://www.ncbi.nlm.nih.gov/pubmed/?term=24421512 DM89JLN DI DM89JLN DM89JLN DN Apixaban DM89JLN MI DES5XRU DM89JLN MN Cytochrome P450 2C8 (CYP2C8) DM89JLN MT DME DM89JLN MA Metabolism DM89JLN RN Apixaban. Hosp Pharm. 2013 Jun;48(6):494-509. DM89JLN RU https://www.ncbi.nlm.nih.gov/pubmed/?term=24421512 DM89JLN DI DM89JLN DM89JLN DN Apixaban DM89JLN MI DE5IED8 DM89JLN MN Cytochrome P450 2C9 (CYP2C9) DM89JLN MT DME DM89JLN MA Metabolism DM89JLN RN Apixaban. Hosp Pharm. 2013 Jun;48(6):494-509. DM89JLN RU https://www.ncbi.nlm.nih.gov/pubmed/?term=24421512 DM89JLN DI DM89JLN DM89JLN DN Apixaban DM89JLN MI DE4LYSA DM89JLN MN Cytochrome P450 3A4 (CYP3A4) DM89JLN MT DME DM89JLN MA Metabolism DM89JLN RN In vitro assessment of metabolic drug-drug interaction potential of apixaban through cytochrome P450 phenotyping, inhibition, and induction studies. Drug Metab Dispos. 2010 Mar;38(3):448-58. DM89JLN RU https://www.ncbi.nlm.nih.gov/pubmed/?term=19940026 DM89JLN DI DM89JLN DM89JLN DN Apixaban DM89JLN MI DEIBDNY DM89JLN MN Cytochrome P450 3A5 (CYP3A5) DM89JLN MT DME DM89JLN MA Metabolism DM89JLN RN Apixaban. After hip or knee replacement: LMWH remains the standard treatment. Prescrire Int. 2012 Sep;21(130):201-2, 204. DM89JLN RU https://www.ncbi.nlm.nih.gov/pubmed/?term=23016247 DM89JLN DI DM89JLN DM89JLN DN Apixaban DM89JLN MI DEGTFWK DM89JLN MN Mephenytoin 4-hydroxylase (CYP2C19) DM89JLN MT DME DM89JLN MA Metabolism DM89JLN RN Apixaban. Hosp Pharm. 2013 Jun;48(6):494-509. DM89JLN RU https://www.ncbi.nlm.nih.gov/pubmed/?term=24421512 DM89JLN DI DM89JLN DM89JLN DN Apixaban DM89JLN MI DTUGYRD DM89JLN MN P-glycoprotein 1 (ABCB1) DM89JLN MT DTP DM89JLN MA Substrate DM89JLN RN Effect of Rifampin on the Pharmacokinetics of Apixaban, an Oral Direct Inhibitor of Factor Xa. Am J Cardiovasc Drugs. 2016 Apr;16(2):119-27. DM89JLN RU http://www.ncbi.nlm.nih.gov/pubmed/26749408 DMX38HQ DI DMX38HQ DMX38HQ DN Apomorphine DMX38HQ MI TTEX248 DMX38HQ MN Dopamine D2 receptor (D2R) DMX38HQ MT DTT DMX38HQ MA Agonist DMX38HQ RN Dopamine D(2/3) receptor occupancy of apomorphine in the nonhuman primate brain--a comparative PET study with [11C]raclopride and [11C]MNPA. Synapse. 2009 May;63(5):378-89. DMX38HQ RU https://pubmed.ncbi.nlm.nih.gov/19173265 DMX38HQ DI DMX38HQ DMX38HQ DN Apomorphine DMX38HQ MI DEYWLRK DMX38HQ MN Sulfotransferase 1A1 (SULT1A1) DMX38HQ MT DME DMX38HQ MA Metabolism DMX38HQ RN Sulfation of apomorphine by human sulfotransferases: evidence of a major role for the polymorphic phenol sulfotransferase, SULT1A1. Xenobiotica. 2003 Nov;33(11):1139-48. DMX38HQ RU https://www.ncbi.nlm.nih.gov/pubmed/?term=14660177 DMO4PVE DI DMO4PVE DMO4PVE DN Apraclonidine DMO4PVE MI TTQ8AFT DMO4PVE MN Adrenergic receptor Alpha-2 (ADRA2) DMO4PVE MT DTT DMO4PVE MA Agonist DMO4PVE RN Apraclonidine attenuates the increases in spinal excitatory amino acid release in rats with adjuvant-induced inflammation. Anesth Analg. 2002 Mar;94(3):701-5; table of contents. DMO4PVE RU https://pubmed.ncbi.nlm.nih.gov/11867401 DMTWS9E DI DMTWS9E DMTWS9E DN Apremilast DMTWS9E MI TT0PG8F DMTWS9E MN Cyclin-dependent kinase 4 (CDK4) DMTWS9E MT DTT DMTWS9E MA Inhibitor DMTWS9E RN Agreement signed with Prostagenics to develop prostate cancer treatment. Innovate Oncology, Inc. 2005. DMTWS9E RU http://www.newsrx.com/newsletters/Law-and-Health-Weekly/2005-05-14/05092005333475LH.html DMTWS9E DI DMTWS9E DMTWS9E DN Apremilast DMTWS9E MI TTO0FDJ DMTWS9E MN Cyclin-dependent kinase 6 (CDK6) DMTWS9E MT DTT DMTWS9E MA Inhibitor DMTWS9E RN Agreement signed with Prostagenics to develop prostate cancer treatment. Innovate Oncology, Inc. 2005. DMTWS9E RU http://www.newsrx.com/newsletters/Law-and-Health-Weekly/2005-05-14/05092005333475LH.html DMTWS9E DI DMTWS9E DMTWS9E DN Apremilast DMTWS9E MI DEJGDUW DMTWS9E MN Cytochrome P450 1A2 (CYP1A2) DMTWS9E MT DME DMTWS9E MA Metabolism DMTWS9E RN Apremilast (Otezla): a new oral treatment for adults with psoriasis and psoriatic arthritis. P T. 2015 Aug;40(8):495-500. DMTWS9E RU https://www.ncbi.nlm.nih.gov/pubmed/?term=26236137 DMTWS9E DI DMTWS9E DMTWS9E DN Apremilast DMTWS9E MI DEJVYAZ DMTWS9E MN Cytochrome P450 2A6 (CYP2A6) DMTWS9E MT DME DMTWS9E MA Metabolism DMTWS9E RN Apremilast (Otezla): a new oral treatment for adults with psoriasis and psoriatic arthritis. P T. 2015 Aug;40(8):495-500. 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DMTWS9E RU https://books.google.com/books?id=0gBRDwAAQBAJ&pg=PP37&lpg=PP37&dq=Methylergonovine+transporter+uptake+efflex&source=bl&ots=cUTe_ppsmZ&sig=ACfU3U3E_YqrDg0CNEuj8K-7lci47HAnrg&hl=zh-CN&sa=X&ved=2ahUKEwjnj-Dk7d7iAhUsK6YKHd5DBDkQ6AEwEnoECAgQAQ#v=onepage&q&f=false DMTWS9E DI DMTWS9E DMTWS9E DN Apremilast DMTWS9E MI TTV5CGO DMTWS9E MN Phosphodiesterase 4 (PDE4) DMTWS9E MT DTT DMTWS9E MA Inhibitor DMTWS9E RN Highly selective phosphodiesterase 4 inhibitors for the treatment of allergic skin diseases and psoriasis. Inflamm Allergy Drug Targets. 2007 Mar;6(1):17-26. DMTWS9E RU https://pubmed.ncbi.nlm.nih.gov/17352685 DM053KT DI DM053KT DM053KT DN Aprepitant DM053KT MI DEJGDUW DM053KT MN Cytochrome P450 1A2 (CYP1A2) DM053KT MT DME DM053KT MA Metabolism DM053KT RN Cytochrome P450 3A4 is the major enzyme involved in the metabolism of the substance P receptor antagonist aprepitant. Drug Metab Dispos. 2004 Nov;32(11):1287-92. DM053KT RU https://www.ncbi.nlm.nih.gov/pubmed/?term=15304427 DM053KT DI DM053KT DM053KT DN Aprepitant DM053KT MI DE4LYSA DM053KT MN Cytochrome P450 3A4 (CYP3A4) DM053KT MT DME DM053KT MA Metabolism DM053KT RN Lack of effect of aprepitant on the pharmacokinetics of docetaxel in cancer patients. Cancer Chemother Pharmacol. 2005 Jun;55(6):609-16. DM053KT RU https://www.ncbi.nlm.nih.gov/pubmed/?term=15723220 DM053KT DI DM053KT DM053KT DN Aprepitant DM053KT MI DEGTFWK DM053KT MN Mephenytoin 4-hydroxylase (CYP2C19) DM053KT MT DME DM053KT MA Metabolism DM053KT RN Cytochrome P450 3A4 is the major enzyme involved in the metabolism of the substance P receptor antagonist aprepitant. Drug Metab Dispos. 2004 Nov;32(11):1287-92. DM053KT RU https://www.ncbi.nlm.nih.gov/pubmed/?term=15304427 DM053KT DI DM053KT DM053KT DN Aprepitant DM053KT MI DTUGYRD DM053KT MN P-glycoprotein 1 (ABCB1) DM053KT MT DTP DM053KT MA Substrate DM053KT RN Improving the prediction of the brain disposition for orally administered drugs using BDDCS. Adv Drug Deliv Rev. 2012 Jan;64(1):95-109. DM053KT RU https://doi.org/10.1016/j.addr.2011.12.008 DM053KT DI DM053KT DM053KT DN Aprepitant DM053KT MI TTZPO1L DM053KT MN Substance-P receptor (TACR1) DM053KT MT DTT DM053KT MA Antagonist DM053KT RN Potent, brain-penetrant, hydroisoindoline-based human neurokinin-1 receptor antagonists. J Med Chem. 2009 May 14;52(9):3039-46. DM053KT RU https://pubmed.ncbi.nlm.nih.gov/19354254 DMBXWU8 DI DMBXWU8 DMBXWU8 DN Aprindine DMBXWU8 MI TTV3NH6 DMBXWU8 MN Calmodulin (CALM) DMBXWU8 MT DTT DMBXWU8 MA Inhibitor DMBXWU8 RN Aprindine inhibits calmodulin-stimulated phosphodiesterase and Ca-ATPase activities. J Cardiovasc Pharmacol. 1983 Jan-Feb;5(1):151-6. 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DMOWK6B RU https://pubmed.ncbi.nlm.nih.gov/12039632 DM0QD4W DI DM0QD4W DM0QD4W DN Aprotinin DM0QD4W MI TTEMV5X DM0QD4W MN Serine protease unspecific (SP) DM0QD4W MT DTT DM0QD4W MA Modulator DM0QD4W RN Randomized controlled trials of aprotinin in cardiac surgery: could clinical equipoise have stopped the bleeding Clin Trials. 2005;2(3):218-29; discussion 229-32. DM0QD4W RU https://pubmed.ncbi.nlm.nih.gov/16279145 DMHTXSL DI DMHTXSL DMHTXSL DN Arbekacin DMHTXSL MI TTA4FIU DMHTXSL MN Ribosome A (hRA) DMHTXSL MT DTT DMHTXSL MA Modulator DMHTXSL RN Natural products as sources of new drugs over the last 25 years. J Nat Prod. 2007 Mar;70(3):461-77. DMHTXSL RU https://pubmed.ncbi.nlm.nih.gov/17309302 DMHTXSL DI DMHTXSL DMHTXSL DN Arbekacin DMHTXSL MI DEZV4AP DMHTXSL MN RNA cytidine acetyltransferase (hALP) DMHTXSL MT DME DMHTXSL MA Metabolism DMHTXSL RN The novel enzymatic 3''-N-acetylation of arbekacin by an aminoglycoside 3-N-acetyltransferase of Streptomyces origin and the resulting activity. J Antibiot (Tokyo). 1998 Aug;51(8):735-42. DMHTXSL RU https://www.ncbi.nlm.nih.gov/pubmed/?term=9766465 DMOQK8Z DI DMOQK8Z DMOQK8Z DN Arbidol DMOQK8Z MI TTF4CAM DMOQK8Z MN Influenza Hemagglutinin (Influ HA) DMOQK8Z MT DTT DMOQK8Z MA Inhibitor DMOQK8Z RN Pharmacokinetic properties and bioequivalence of two formulations of arbidol: an open-label, single-dose, randomized-sequence, two-period crossover study in healthy Chinese male volunteers. Clin Ther. 2009 Apr;31(4):784-92. DMOQK8Z RU https://pubmed.ncbi.nlm.nih.gov/19446151 DMCY8AF DI DMCY8AF DMCY8AF DN Arbutamine DMCY8AF MI TTR6W5O DMCY8AF MN Adrenergic receptor beta-1 (ADRB1) DMCY8AF MT DTT DMCY8AF MA Stimulator DMCY8AF RN Characterization of the adrenergic activity of arbutamine, a novel agent for pharmacological stress testing. Cardiovasc Drugs Ther. 1996 Mar;10(1):39-47. DMCY8AF RU https://pubmed.ncbi.nlm.nih.gov/8723169 DM9GH25 DI DM9GH25 DM9GH25 DN Arcitumomab DM9GH25 MI TTPX7I5 DM9GH25 MN Carcinoembryonic antigen CGM1 (CD66d) DM9GH25 MT DTT DM9GH25 RN In vivo near-infrared fluorescence imaging of carcinoembryonic antigen-expressing tumor cells in mice. Radiology. 2008 Jun;247(3):779-87. DM9GH25 RU https://pubmed.ncbi.nlm.nih.gov/18413884 DMYRX8B DI DMYRX8B DMYRX8B DN Ardeparin DMYRX8B MI TT4QPUL DMYRX8B MN Antithrombin-III (ATIII) DMYRX8B MT DTT DMYRX8B MA Modulator DMYRX8B RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. DMYRX8B RU https://www.fda.gov/ DMVMY7K DI DMVMY7K DMVMY7K DN Arepanrix DMVMY7K MI TT3J5ZI DMVMY7K MN Cell mediated immunity response (CMIR) DMVMY7K MT DTT DMVMY7K RN Comparison of Pandemrix and Arepanrix, two pH1N1 AS03-adjuvanted vaccines differentially associated with narcolepsy development. Brain Behav Immun. 2015 Jul;47:44-57. DMVMY7K RU https://pubmed.ncbi.nlm.nih.gov/25452148 DMYM974 DI DMYM974 DMYM974 DN Arformoterol DMYM974 MI TT2CJVK DMYM974 MN Adrenergic receptor beta-2 (ADRB2) DMYM974 MT DTT DMYM974 MA Agonist DMYM974 RN Arformoterol tartrate in the treatment of bronchoconstriction in patients with chronic obstructive pulmonary disease. Drugs Today (Barc). 2009 Jan;45(1):3-9. DMYM974 RU https://pubmed.ncbi.nlm.nih.gov/19271027 DMYM974 DI DMYM974 DMYM974 DN Arformoterol DMYM974 MI DEJVYAZ DMYM974 MN Cytochrome P450 2A6 (CYP2A6) DMYM974 MT DME DMYM974 MA Metabolism DMYM974 RN A comparison of the expression and metabolizing activities of phase I and II enzymes in freshly isolated human lung parenchymal cells and cryopreserved human hepatocytes. Drug Metab Dispos. 2007 Oct;35(10):1797-805. DMYM974 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=17627976 DMYM974 DI DMYM974 DMYM974 DN Arformoterol DMYM974 MI DECB0K3 DMYM974 MN Cytochrome P450 2D6 (CYP2D6) DMYM974 MT DME DMYM974 MA Metabolism DMYM974 RN A comparison of the expression and metabolizing activities of phase I and II enzymes in freshly isolated human lung parenchymal cells and cryopreserved human hepatocytes. Drug Metab Dispos. 2007 Oct;35(10):1797-805. DMYM974 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=17627976 DMYM974 DI DMYM974 DMYM974 DN Arformoterol DMYM974 MI DEGTFWK DMYM974 MN Mephenytoin 4-hydroxylase (CYP2C19) DMYM974 MT DME DMYM974 MA Metabolism DMYM974 RN A comparison of the expression and metabolizing activities of phase I and II enzymes in freshly isolated human lung parenchymal cells and cryopreserved human hepatocytes. Drug Metab Dispos. 2007 Oct;35(10):1797-805. DMYM974 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=17627976 DMFI46A DI DMFI46A DMFI46A DN Argatroban DMFI46A MI TT6L509 DMFI46A MN Coagulation factor IIa (F2) DMFI46A MT DTT DMFI46A MA Inhibitor DMFI46A RN Studies on the different modes of action of the anticoagulant protease inhibitors DX-9065a and Argatroban. I. Effects on thrombin generation. J Biol Chem. 2002 Dec 27;277(52):50439-44. DMFI46A RU https://pubmed.ncbi.nlm.nih.gov/12496240 DMFI46A DI DMFI46A DMFI46A DN Argatroban DMFI46A MI DE4LYSA DMFI46A MN Cytochrome P450 3A4 (CYP3A4) DMFI46A MT DME DMFI46A MA Metabolism DMFI46A RN Assessment of the potential pharmacokinetic and pharmacodynamic interactions between erythromycin and argatroban. J Clin Pharmacol. 1999 May;39(5):513-9. DMFI46A RU https://www.ncbi.nlm.nih.gov/pubmed/?term=10234600 DMFI46A DI DMFI46A DMFI46A DN Argatroban DMFI46A MI DEIBDNY DMFI46A MN Cytochrome P450 3A5 (CYP3A5) DMFI46A MT DME DMFI46A MA Metabolism DMFI46A RN Assessment of the potential pharmacokinetic and pharmacodynamic interactions between erythromycin and argatroban. J Clin Pharmacol. 1999 May;39(5):513-9. DMFI46A RU https://www.ncbi.nlm.nih.gov/pubmed/?term=10234600 DMRE4FC DI DMRE4FC DMRE4FC DN Arginine DMRE4FC MI DTDPJ3F DMRE4FC MN Mitochondrial ornithine transporter 2 (SLC25A2) DMRE4FC MT DTP DMRE4FC MA Substrate DMRE4FC RN Asymmetric dimethylarginine is transported by the mitochondrial carrier SLC25A2. Amino Acids. 2016 Feb;48(2):427-36. DMRE4FC RU http://www.ncbi.nlm.nih.gov/pubmed/26403849 DMRE4FC DI DMRE4FC DMRE4FC DN Arginine DMRE4FC MI DT96BT4 DMRE4FC MN Mitochondrial ornithine transporter 3 (SLC25A29) DMRE4FC MT DTP DMRE4FC MA Substrate DMRE4FC RN The human gene SLC25A29, of solute carrier family 25, encodes a mitochondrial transporter of basic amino acids. J Biol Chem. 2014 May 9;289(19):13374-84. DMRE4FC RU http://www.ncbi.nlm.nih.gov/pubmed/24652292 DMRE4FC DI DMRE4FC DMRE4FC DN Arginine DMRE4FC MI DTF7MYK DMRE4FC MN Sodium-coupled neutral amino acid transporter 9 (SLC38A9) DMRE4FC MT DTP DMRE4FC MA Substrate DMRE4FC RN Metabolism. Lysosomal amino acid transporter SLC38A9 signals arginine sufficiency to mTORC1. Science. 2015 Jan 9;347(6218):188-94. DMRE4FC RU http://www.ncbi.nlm.nih.gov/pubmed/25567906 DM3NUMH DI DM3NUMH DM3NUMH DN Aripiprazole DM3NUMH MI DECB0K3 DM3NUMH MN Cytochrome P450 2D6 (CYP2D6) DM3NUMH MT DME DM3NUMH MA Metabolism DM3NUMH RN Aripiprazole: a review of its use in schizophrenia and schizoaffective disorder. Drugs. 2004;64(15):1715-36. DM3NUMH RU https://www.ncbi.nlm.nih.gov/pubmed/?term=15257633 DM3NUMH DI DM3NUMH DM3NUMH DN Aripiprazole DM3NUMH MI DE4LYSA DM3NUMH MN Cytochrome P450 3A4 (CYP3A4) DM3NUMH MT DME DM3NUMH MA Metabolism DM3NUMH RN Aripiprazole: a review of its use in schizophrenia and schizoaffective disorder. Drugs. 2004;64(15):1715-36. DM3NUMH RU https://www.ncbi.nlm.nih.gov/pubmed/?term=15257633 DM3NUMH DI DM3NUMH DM3NUMH DN Aripiprazole DM3NUMH MI DEIBDNY DM3NUMH MN Cytochrome P450 3A5 (CYP3A5) DM3NUMH MT DME DM3NUMH MA Metabolism DM3NUMH RN Drug Interactions Flockhart Table DM3NUMH RU https://drug-interactions.medicine.iu.edu/Main-Table.aspx DM3NUMH DI DM3NUMH DM3NUMH DN Aripiprazole DM3NUMH MI DERD86B DM3NUMH MN Cytochrome P450 3A7 (CYP3A7) DM3NUMH MT DME DM3NUMH MA Metabolism DM3NUMH RN Drug Interactions Flockhart Table DM3NUMH RU https://drug-interactions.medicine.iu.edu/Main-Table.aspx DM3NUMH DI DM3NUMH DM3NUMH DN Aripiprazole DM3NUMH MI TTEX248 DM3NUMH MN Dopamine D2 receptor (D2R) DM3NUMH MT DTT DM3NUMH MA Agonist DM3NUMH RN Aripiprazole acts as a selective dopamine D2 receptor partial agonist. Expert Opin Investig Drugs. 2007 Jun;16(6):771-5. DM3NUMH RU https://pubmed.ncbi.nlm.nih.gov/17501690 DMGB035 DI DMGB035 DMGB035 DN Armodafinil DMGB035 MI TT34BHT DMGB035 MN Adrenergic receptor alpha-1D (ADRA1D) DMGB035 MT DTT DMGB035 MA Agonist DMGB035 RN Mechanisms of modafinil: A review of current research. Neuropsychiatr Dis Treat. 2007 June; 3(3): 349-364. DMGB035 RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2654794/ DMGB035 DI DMGB035 DMGB035 DN Armodafinil DMGB035 MI DE4LYSA DMGB035 MN Cytochrome P450 3A4 (CYP3A4) DMGB035 MT DME DMGB035 MA Metabolism DMGB035 RN Interaction profile of armodafinil with medications metabolized by cytochrome P450 enzymes 1A2, 3A4 and 2C19 in healthy subjects. Clin Pharmacokinet. 2008;47(1):61-74. DMGB035 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=18076219 DMGB035 DI DMGB035 DMGB035 DN Armodafinil DMGB035 MI DEIBDNY DMGB035 MN Cytochrome P450 3A5 (CYP3A5) DMGB035 MT DME DMGB035 MA Metabolism DMGB035 RN Clinical pharmacokinetic profile of modafinil. Clin Pharmacokinet. 2003;42(2):123-37. DMGB035 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=12537513 DMT81LZ DI DMT81LZ DMT81LZ DN Arn-509 DMT81LZ MI TTS64P2 DMT81LZ MN Androgen receptor (AR) DMT81LZ MT DTT DMT81LZ MA Inhibitor DMT81LZ RN 2018 FDA drug approvals.Nat Rev Drug Discov. 2019 Feb;18(2):85-89. DMT81LZ RU https://pubmed.ncbi.nlm.nih.gov/30710142 DMT81LZ DI DMT81LZ DMT81LZ DN Arn-509 DMT81LZ MI DES5XRU DMT81LZ MN Cytochrome P450 2C8 (CYP2C8) DMT81LZ MT DME DMT81LZ MA Metabolism DMT81LZ RN Apalutamide: first global approval. Drugs. 2018 Apr;78(6):699-705. DMT81LZ RU https://www.ncbi.nlm.nih.gov/pubmed/?term=29626324 DMT81LZ DI DMT81LZ DMT81LZ DN Arn-509 DMT81LZ MI DE4LYSA DMT81LZ MN Cytochrome P450 3A4 (CYP3A4) DMT81LZ MT DME DMT81LZ MA Metabolism DMT81LZ RN Apalutamide: first global approval. Drugs. 2018 Apr;78(6):699-705. DMT81LZ RU https://www.ncbi.nlm.nih.gov/pubmed/?term=29626324 DM1P6FR DI DM1P6FR DM1P6FR DN Arry-162 DM1P6FR MI DTI7UX6 DM1P6FR MN Breast cancer resistance protein (ABCG2) DM1P6FR MT DTP DM1P6FR MA Substrate DM1P6FR RN The impact of P-glycoprotein and breast cancer resistance protein on the brain pharmacokinetics and pharmacodynamics of a panel of MEK inhibitors. Int J Cancer. 2018 Jan 15;142(2):381-391. DM1P6FR RU http://www.ncbi.nlm.nih.gov/pubmed/28921565 DM1P6FR DI DM1P6FR DM1P6FR DN Arry-162 DM1P6FR MI DEJGDUW DM1P6FR MN Cytochrome P450 1A2 (CYP1A2) DM1P6FR MT DME DM1P6FR MA Metabolism DM1P6FR RN FDA Label of Binimetinib. The 2020 official website of the U.S. Food and Drug Administration. DM1P6FR RU https://www.accessdata.fda.gov/drugsatfda_docs/label/2018/210498lbl.pdf DM1P6FR DI DM1P6FR DM1P6FR DN Arry-162 DM1P6FR MI TTZCRP3 DM1P6FR MN ERK activator kinase (MEK) DM1P6FR MT DTT DM1P6FR MA Inhibitor DM1P6FR RN 2018 FDA drug approvals.Nat Rev Drug Discov. 2019 Feb;18(2):85-89. DM1P6FR RU https://pubmed.ncbi.nlm.nih.gov/30710142 DM1P6FR DI DM1P6FR DM1P6FR DN Arry-162 DM1P6FR MI TTROQ37 DM1P6FR MN MAPK/ERK kinase kinase (MAP3K) DM1P6FR MT DTT DM1P6FR MA Modulator DM1P6FR RN MEK and the inhibitors: from bench to bedside. J Hematol Oncol. 2013; 6: 27. DM1P6FR RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3626705/ DM1P6FR DI DM1P6FR DM1P6FR DN Arry-162 DM1P6FR MI DTUGYRD DM1P6FR MN P-glycoprotein 1 (ABCB1) DM1P6FR MT DTP DM1P6FR MA Substrate DM1P6FR RN The impact of P-glycoprotein and breast cancer resistance protein on the brain pharmacokinetics and pharmacodynamics of a panel of MEK inhibitors. Int J Cancer. 2018 Jan 15;142(2):381-391. DM1P6FR RU http://www.ncbi.nlm.nih.gov/pubmed/28921565 DM1P6FR DI DM1P6FR DM1P6FR DN Arry-162 DM1P6FR MI DEYGVN4 DM1P6FR MN UDP-glucuronosyltransferase 1A1 (UGT1A1) DM1P6FR MT DME DM1P6FR MA Metabolism DM1P6FR RN Binimetinib - European Medicines Agency - European Union DM1P6FR RU https://www.ema.europa.eu/en/documents/withdrawal-report/withdrawal-assessment-report-balimek-binimetinib_en.pdf DMTL2Y1 DI DMTL2Y1 DMTL2Y1 DN Arsenic DMTL2Y1 MI DE9KJP3 DMTL2Y1 MN Arsenite methyltransferase (AS3MT) DMTL2Y1 MT DME DMTL2Y1 MA Metabolism DMTL2Y1 RN Polymorphisms in arsenic(+III oxidation state) methyltransferase (AS3MT) predict gene expression of AS3MT as well as arsenic metabolism. Environ Health Perspect. 2011 Feb;119(2):182-8. DMTL2Y1 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=21247820 DMTL2Y1 DI DMTL2Y1 DMTL2Y1 DN Arsenic DMTL2Y1 MI DEOT0QC DMTL2Y1 MN Methylarsonite methyltransferase N6AMT1 (N6AMT1) DMTL2Y1 MT DME DMTL2Y1 MA Metabolism DMTL2Y1 RN Interactive influence of N6AMT1 and As3MT genetic variations on arsenic metabolism in the population of Inner Mongolia, China. Toxicol Sci. 2017 Jan;155(1):124-134. DMTL2Y1 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=27637898 DMTL2Y1 DI DMTL2Y1 DMTL2Y1 DN Arsenic DMTL2Y1 MI DEYLWI6 DMTL2Y1 MN Serine sulfhydrase (CBS) DMTL2Y1 MT DME DMTL2Y1 MA Metabolism DMTL2Y1 RN Association of genetic variation in cystathionine-beta-synthase and arsenic metabolism. Environ Res. 2010 Aug;110(6):580-7. DMTL2Y1 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=20670920 DM61TA4 DI DM61TA4 DM61TA4 DN Arsenic trioxide DM61TA4 MI TTJ3E9X DM61TA4 MN Inhibitor of nuclear factor kappa-B kinase beta (IKKB) DM61TA4 MT DTT DM61TA4 MA Inhibitor DM61TA4 RN How acute promyelocytic leukaemia revived arsenic. Nat Rev Cancer. 2002 Sep;2(9):705-13. DM61TA4 RU https://pubmed.ncbi.nlm.nih.gov/12209159 DM61TA4 DI DM61TA4 DM61TA4 DN Arsenic trioxide DM61TA4 MI DTFI42L DM61TA4 MN Multidrug resistance-associated protein 2 (ABCC2) DM61TA4 MT DTP DM61TA4 MA Substrate DM61TA4 RN MRP2 and acquired tolerance to inorganic arsenic in the kidney of killifish (Fundulus heteroclitus). Toxicol Sci. 2007 May;97(1):103-10. DM61TA4 RU http://www.ncbi.nlm.nih.gov/pubmed/17324950 DM61TA4 DI DM61TA4 DM61TA4 DN Arsenic trioxide DM61TA4 MI DTUGYRD DM61TA4 MN P-glycoprotein 1 (ABCB1) DM61TA4 MT DTP DM61TA4 MA Substrate DM61TA4 RN Arsenic trioxide induces apoptosis equally in T lymphoblastoid leukemia MOLT-4 cells and P-gp-expressing daunorubicin-resistant MOLT-4 cells. Cancer Chemother Pharmacol. 2003 Feb;51(2):119-26. DM61TA4 RU http://www.ncbi.nlm.nih.gov/pubmed/12647012 DMQLX7O DI DMQLX7O DMQLX7O DN Arteether DMQLX7O MI TT9X7H4 DMQLX7O MN Beta-hematin formation (BHF) DMQLX7O MT DTT DMQLX7O MA Modulator DMQLX7O RN Lack of association of the S769N mutation in Plasmodium falciparum SERCA (PfATP6) with resistance to artemisinins. Antimicrob Agents Chemother. 2012 May;56(5):2546-52. DMQLX7O RU https://pubmed.ncbi.nlm.nih.gov/22354307 DM48QOT DI DM48QOT DM48QOT DN Artemether DM48QOT MI DEPKLMQ DM48QOT MN Cytochrome P450 2B6 (CYP2B6) DM48QOT MT DME DM48QOT MA Metabolism DM48QOT RN Insights into CYP2B6-mediated drug-drug interactions. Acta Pharm Sin B. 2016 Sep;6(5):413-425. DM48QOT RU https://www.ncbi.nlm.nih.gov/pubmed/?term=27709010 DM48QOT DI DM48QOT DM48QOT DN Artemether DM48QOT MI DE5IED8 DM48QOT MN Cytochrome P450 2C9 (CYP2C9) DM48QOT MT DME DM48QOT MA Metabolism DM48QOT RN Pharmacokinetic interaction between etravirine or darunavir/ritonavir and artemether/lumefantrine in healthy volunteers: a two-panel, two-way, two-period, randomized trial. HIV Med. 2013 Aug;14(7):421-9. DM48QOT RU https://www.ncbi.nlm.nih.gov/pubmed/?term=23441978 DM48QOT DI DM48QOT DM48QOT DN Artemether DM48QOT MI DECB0K3 DM48QOT MN Cytochrome P450 2D6 (CYP2D6) DM48QOT MT DME DM48QOT MA Metabolism DM48QOT RN The contribution of the enzymes CYP2D6 and CYP2C19 in the demethylation of artemether in healthy subjects. Eur J Drug Metab Pharmacokinet. 1998 Jul-Sep;23(3):429-36. DM48QOT RU https://www.ncbi.nlm.nih.gov/pubmed/?term=9842988 DM48QOT DI DM48QOT DM48QOT DN Artemether DM48QOT MI DE4LYSA DM48QOT MN Cytochrome P450 3A4 (CYP3A4) DM48QOT MT DME DM48QOT MA Metabolism DM48QOT RN The effect of grapefruit juice on the time-dependent decline of artemether plasma levels in healthy subjects. Clin Pharmacol Ther. 1999 Oct;66(4):408-14. DM48QOT RU https://www.ncbi.nlm.nih.gov/pubmed/?term=10546925 DM48QOT DI DM48QOT DM48QOT DN Artemether DM48QOT MI DEIBDNY DM48QOT MN Cytochrome P450 3A5 (CYP3A5) DM48QOT MT DME DM48QOT MA Metabolism DM48QOT RN Effect of pharmacogenetics on plasma lumefantrine pharmacokinetics and malaria treatment outcome in pregnant women. Malar J. 2017 Jul 3;16(1):267. DM48QOT RU https://www.ncbi.nlm.nih.gov/pubmed/?term=28673292 DM48QOT DI DM48QOT DM48QOT DN Artemether DM48QOT MI DEGTFWK DM48QOT MN Mephenytoin 4-hydroxylase (CYP2C19) DM48QOT MT DME DM48QOT MA Metabolism DM48QOT RN The contribution of the enzymes CYP2D6 and CYP2C19 in the demethylation of artemether in healthy subjects. Eur J Drug Metab Pharmacokinet. 1998 Jul-Sep;23(3):429-36. DM48QOT RU https://www.ncbi.nlm.nih.gov/pubmed/?term=9842988 DM48QOT DI DM48QOT DM48QOT DN Artemether DM48QOT MI TTWK8D0 DM48QOT MN Sodium pump subunit alpha-1 (ATP1A1) DM48QOT MT DTT DM48QOT MA Binder DM48QOT RN The fight against drug-resistant malaria: novel plasmodial targets and antimalarial drugs. Curr Med Chem. 2008;15(2):161-71. DM48QOT RU https://pubmed.ncbi.nlm.nih.gov/18220771 DMOY7W3 DI DMOY7W3 DMOY7W3 DN Artemisinin DMOY7W3 MI DEJVYAZ DMOY7W3 MN Cytochrome P450 2A6 (CYP2A6) DMOY7W3 MT DME DMOY7W3 MA Metabolism DMOY7W3 RN Identification of the human cytochrome P450 enzymes involved in the in vitro metabolism of artemisinin. Br J Clin Pharmacol. 1999 Oct;48(4):528-35. DMOY7W3 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=10583023 DMOY7W3 DI DMOY7W3 DMOY7W3 DN Artemisinin DMOY7W3 MI DEPKLMQ DMOY7W3 MN Cytochrome P450 2B6 (CYP2B6) DMOY7W3 MT DME DMOY7W3 MA Metabolism DMOY7W3 RN Antimalarial artemisinin drugs induce cytochrome P450 and MDR1 expression by activation of xenosensors pregnane X receptor and constitutive androstane receptor. Mol Pharmacol. 2005 Jun;67(6):1954-65. DMOY7W3 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=15761118 DMOY7W3 DI DMOY7W3 DMOY7W3 DN Artemisinin DMOY7W3 MI DE4LYSA DMOY7W3 MN Cytochrome P450 3A4 (CYP3A4) DMOY7W3 MT DME DMOY7W3 MA Metabolism DMOY7W3 RN Antimalarial artemisinin drugs induce cytochrome P450 and MDR1 expression by activation of xenosensors pregnane X receptor and constitutive androstane receptor. Mol Pharmacol. 2005 Jun;67(6):1954-65. DMOY7W3 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=15761118 DMOY7W3 DI DMOY7W3 DMOY7W3 DN Artemisinin DMOY7W3 MI DE4ZHS1 DMOY7W3 MN Glutathione S-transferase alpha-1 (GSTA1) DMOY7W3 MT DME DMOY7W3 MA Metabolism DMOY7W3 RN Inhibition of glutathione S-transferases by antimalarial drugs possible implications for circumventing anticancer drug resistance. Int J Cancer. 2002 Feb 10;97(5):700-5. DMOY7W3 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=11807801 DMOY7W3 DI DMOY7W3 DMOY7W3 DN Artemisinin DMOY7W3 MI TT3PQ2Y DMOY7W3 MN Plasmodium Dihydroorotate dehydrogenase (Malaria DHOdehase) DMOY7W3 MT DTT DMOY7W3 MA Inhibitor DMOY7W3 RN The fight against drug-resistant malaria: novel plasmodial targets and antimalarial drugs. Curr Med Chem. 2008;15(2):161-71. DMOY7W3 RU https://pubmed.ncbi.nlm.nih.gov/18220771 DMOY7W3 DI DMOY7W3 DMOY7W3 DN Artemisinin DMOY7W3 MI TTZVSJ2 DMOY7W3 MN Sarcoplasmic/endoplasmic reticulum calcium ATPase (ATP2A) DMOY7W3 MT DTT DMOY7W3 MA Inhibitor DMOY7W3 RN The fight against drug-resistant malaria: novel plasmodial targets and antimalarial drugs. Curr Med Chem. 2008;15(2):161-71. DMOY7W3 RU https://pubmed.ncbi.nlm.nih.gov/18220771 DMFETDK DI DMFETDK DMFETDK DN Artemisinin SP DMFETDK MI TTAN6JD DMFETDK MN Glutamate receptor AMPA (GRIA) DMFETDK MT DTT DMFETDK MA Agonist DMFETDK RN GABA(A) receptor ligands and their therapeutic potentials. Curr Top Med Chem. 2002 Aug;2(8):817-32. DMFETDK RU https://pubmed.ncbi.nlm.nih.gov/12171573 DMFETDK DI DMFETDK DMFETDK DN Artemisinin SP DMFETDK MI TTZVSJ2 DMFETDK MN Sarcoplasmic/endoplasmic reticulum calcium ATPase (ATP2A) DMFETDK MT DTT DMFETDK MA Inhibitor DMFETDK RN The fight against drug-resistant malaria: novel plasmodial targets and antimalarial drugs. Curr Med Chem. 2008;15(2):161-71. DMFETDK RU https://pubmed.ncbi.nlm.nih.gov/18220771 DMR27C8 DI DMR27C8 DMR27C8 DN Artesunate DMR27C8 MI DEJVYAZ DMR27C8 MN Cytochrome P450 2A6 (CYP2A6) DMR27C8 MT DME DMR27C8 MA Metabolism DMR27C8 RN Identification of human cytochrome P(450)s that metabolise anti-parasitic drugs and predictions of in vivo drug hepatic clearance from in vitro data. Eur J Clin Pharmacol. 2003 Sep;59(5-6):429-42. DMR27C8 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=12920490 DMR27C8 DI DMR27C8 DMR27C8 DN Artesunate DMR27C8 MI TTZVSJ2 DMR27C8 MN Sarcoplasmic/endoplasmic reticulum calcium ATPase (ATP2A) DMR27C8 MT DTT DMR27C8 MA Inhibitor DMR27C8 RN The fight against drug-resistant malaria: novel plasmodial targets and antimalarial drugs. Curr Med Chem. 2008;15(2):161-71. DMR27C8 RU https://pubmed.ncbi.nlm.nih.gov/18220771 DMOKCVI DI DMOKCVI DMOKCVI DN ARZOXIFENE DMOKCVI MI TTZAYWL DMOKCVI MN Estrogen receptor (ESR) DMOKCVI MT DTT DMOKCVI MA Inhibitor DMOKCVI RN Benzothiophene selective estrogen receptor modulators with modulated oxidative activity and receptor affinity. J Med Chem. 2007 May 31;50(11):2682-92. DMOKCVI RU https://pubmed.ncbi.nlm.nih.gov/17489582 DMOKCVI DI DMOKCVI DMOKCVI DN ARZOXIFENE DMOKCVI MI TTOM3J0 DMOKCVI MN Estrogen receptor beta (ESR2) DMOKCVI MT DTT DMOKCVI MA Inhibitor DMOKCVI RN Benzothiophene selective estrogen receptor modulators with modulated oxidative activity and receptor affinity. J Med Chem. 2007 May 31;50(11):2682-92. DMOKCVI RU https://pubmed.ncbi.nlm.nih.gov/17489582 DMV05SW DI DMV05SW DMV05SW DN As-1670542 DMV05SW MI TTIHYA4 DMV05SW MN Thrombopoietin receptor (MPL) DMV05SW MT DTT DMV05SW MA Agonist DMV05SW RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1722). DMV05SW RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1722 DMCZIHT DI DMCZIHT DMCZIHT DN Asasantin DMCZIHT MI TTK0943 DMCZIHT MN Prostaglandin G/H synthase (COX) DMCZIHT MT DTT DMCZIHT MA Inhibitor DMCZIHT RN Emerging drugs in peripheral arterial disease. Expert Opin Emerg Drugs. 2006 Mar;11(1):75-90. DMCZIHT RU https://pubmed.ncbi.nlm.nih.gov/16503827 DMSQZE2 DI DMSQZE2 DMSQZE2 DN Asenapine DMSQZE2 MI DEJGDUW DMSQZE2 MN Cytochrome P450 1A2 (CYP1A2) DMSQZE2 MT DME DMSQZE2 MA Metabolism DMSQZE2 RN Asenapine review, part I: chemistry, receptor affinity profile, pharmacokinetics and metabolism. Expert Opin Drug Metab Toxicol. 2014 Jun;10(6):893-903. DMSQZE2 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=24793403 DMSQZE2 DI DMSQZE2 DMSQZE2 DN Asenapine DMSQZE2 MI DECB0K3 DMSQZE2 MN Cytochrome P450 2D6 (CYP2D6) DMSQZE2 MT DME DMSQZE2 MA Metabolism DMSQZE2 RN Asenapine review, part I: chemistry, receptor affinity profile, pharmacokinetics and metabolism. Expert Opin Drug Metab Toxicol. 2014 Jun;10(6):893-903. DMSQZE2 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=24793403 DMSQZE2 DI DMSQZE2 DMSQZE2 DN Asenapine DMSQZE2 MI DE4LYSA DMSQZE2 MN Cytochrome P450 3A4 (CYP3A4) DMSQZE2 MT DME DMSQZE2 MA Metabolism DMSQZE2 RN Asenapine for the treatment of manic and mixed episodes associated with bipolar I disorder: from clinical research to clinical practice. Expert Opin Pharmacother. 2013 Mar;14(4):489-504. DMSQZE2 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=23356509 DMSQZE2 DI DMSQZE2 DMSQZE2 DN Asenapine DMSQZE2 MI TTXFI1K DMSQZE2 MN Hyaluronidase (HYAL) DMSQZE2 MT DTT DMSQZE2 MA Modulator DMSQZE2 RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. DMSQZE2 RU https://www.fda.gov/ DMM4FXA DI DMM4FXA DMM4FXA DN Asfotase alfa DMM4FXA MI TTMR5UV DMM4FXA MN Alkaline phosphatase tissue-nonspecific (ALPL) DMM4FXA MT DTT DMM4FXA MA Modulator DMM4FXA RN Enzyme-replacement therapy in life-threatening hypophosphatasia. N Engl J Med. 2012 Mar 8;366(10):904-13. DMM4FXA RU https://pubmed.ncbi.nlm.nih.gov/22397652 DM672AH DI DM672AH DM672AH DN Aspirin DM672AH MI DE5IED8 DM672AH MN Cytochrome P450 2C9 (CYP2C9) DM672AH MT DME DM672AH MA Metabolism DM672AH RN Polymorphisms of Aspirin-Metabolizing Enzymes CYP2C9, NAT2 and UGT1A6 in Aspirin-Intolerant Urticaria. Allergy Asthma Immunol Res. 2011 Oct;3(4):273-6. DM672AH RU https://www.ncbi.nlm.nih.gov/pubmed/?term=21966608 DM672AH DI DM672AH DM672AH DN Aspirin DM672AH MI TTPADOQ DM672AH MN HMG-CoA reductase (HMGCR) DM672AH MT DTT DM672AH MA Inhibitor DM672AH RN Emerging drugs in peripheral arterial disease. Expert Opin Emerg Drugs. 2006 Mar;11(1):75-90. DM672AH RU https://pubmed.ncbi.nlm.nih.gov/16503827 DM672AH DI DM672AH DM672AH DN Aspirin DM672AH MI DEGTFWK DM672AH MN Mephenytoin 4-hydroxylase (CYP2C19) DM672AH MT DME DM672AH MA Metabolism DM672AH RN Isozyme-specific induction of low-dose aspirin on cytochrome P450 in healthy subjects. Clin Pharmacol Ther. 2003 Mar;73(3):264-71. DM672AH RU https://www.ncbi.nlm.nih.gov/pubmed/?term=12621391 DM672AH DI DM672AH DM672AH DN Aspirin DM672AH MI DER7TA0 DM672AH MN N-acetyltransferase 2 (NAT2) DM672AH MT DME DM672AH MA Metabolism DM672AH RN Polymorphisms of Aspirin-Metabolizing Enzymes CYP2C9, NAT2 and UGT1A6 in Aspirin-Intolerant Urticaria. Allergy Asthma Immunol Res. 2011 Oct;3(4):273-6. DM672AH RU https://www.ncbi.nlm.nih.gov/pubmed/?term=21966608 DM672AH DI DM672AH DM672AH DN Aspirin DM672AH MI DT0OC1Q DM672AH MN Organic anion transporter 2 (SLC22A7) DM672AH MT DTP DM672AH MA Substrate DM672AH RN Identification of multispecific organic anion transporter 2 expressed predominantly in the liver. FEBS Lett. 1998 Jun 12;429(2):179-82. DM672AH RU http://www.ncbi.nlm.nih.gov/pubmed/9650585 DM672AH DI DM672AH DM672AH DN Aspirin DM672AH MI DTUGYRD DM672AH MN P-glycoprotein 1 (ABCB1) DM672AH MT DTP DM672AH MA Substrate DM672AH RN Caco-2 permeability, P-glycoprotein transport ratios and brain penetration of heterocyclic drugs. Int J Pharm. 2003 Sep 16;263(1-2):113-22. DM672AH RU http://www.ncbi.nlm.nih.gov/pubmed/12954186 DM672AH DI DM672AH DM672AH DN Aspirin DM672AH MI DTHE530 DM672AH MN Probable small intestine urate exporter (SLC17A4) DM672AH MT DTP DM672AH MA Substrate DM672AH RN A Na+-phosphate cotransporter homologue (SLC17A4 protein) is an intestinal organic anion exporter. Am J Physiol Cell Physiol. 2012 Jun 1;302(11):C1652-60. DM672AH RU http://www.ncbi.nlm.nih.gov/pubmed/22460716 DM672AH DI DM672AH DM672AH DN Aspirin DM672AH MI TTK0943 DM672AH MN Prostaglandin G/H synthase (COX) DM672AH MT DTT DM672AH MA Inhibitor DM672AH RN Cyclooxygenase inhibitors: instrumental drugs to understand cardiovascular homeostasis and arterial thrombosis. Cardiovasc Hematol Disord Drug Targets. 2008 Dec;8(4):268-77. DM672AH RU https://pubmed.ncbi.nlm.nih.gov/19075637 DM672AH DI DM672AH DM672AH DN Aspirin DM672AH MI DT8ARWJ DM672AH MN Sodium-dependent phosphate transport protein 1 (SLC17A1) DM672AH MT DTP DM672AH MA Substrate DM672AH RN Type 1 sodium-dependent phosphate transporter (SLC17A1 Protein) is a Cl(-)-dependent urate exporter. J Biol Chem. 2010 Aug 20;285(34):26107-13. DM672AH RU http://www.ncbi.nlm.nih.gov/pubmed/20566650 DM672AH DI DM672AH DM672AH DN Aspirin DM672AH MI DEYWLRK DM672AH MN Sulfotransferase 1A1 (SULT1A1) DM672AH MT DME DM672AH MA Metabolism DM672AH RN Inhibition of human phenol and estrogen sulfotransferase by certain non-steroidal anti-inflammatory agents. Curr Drug Metab. 2006 Oct;7(7):745-53. DM672AH RU https://www.ncbi.nlm.nih.gov/pubmed/?term=17073578 DM672AH DI DM672AH DM672AH DN Aspirin DM672AH MI DEYGVN4 DM672AH MN UDP-glucuronosyltransferase 1A1 (UGT1A1) DM672AH MT DME DM672AH MA Metabolism DM672AH RN Pharmacogenomics in aspirin intolerance. Curr Drug Metab. 2009 Nov;10(9):998-1008. DM672AH RU https://www.ncbi.nlm.nih.gov/pubmed/?term=20214591 DM672AH DI DM672AH DM672AH DN Aspirin DM672AH MI DESD26P DM672AH MN UDP-glucuronosyltransferase 1A6 (UGT1A6) DM672AH MT DME DM672AH MA Metabolism DM672AH RN Polymorphisms of Aspirin-Metabolizing Enzymes CYP2C9, NAT2 and UGT1A6 in Aspirin-Intolerant Urticaria. Allergy Asthma Immunol Res. 2011 Oct;3(4):273-6. DM672AH RU https://www.ncbi.nlm.nih.gov/pubmed/?term=21966608 DMSYRBX DI DMSYRBX DMSYRBX DN Atazanavir DMSYRBX MI DE5IED8 DMSYRBX MN Cytochrome P450 2C9 (CYP2C9) DMSYRBX MT DME DMSYRBX MA Metabolism DMSYRBX RN Atazanavir for the treatment of human immunodeficiency virus infection. Pharmacotherapy. 2004 Dec;24(12):1732-47. DMSYRBX RU https://www.ncbi.nlm.nih.gov/pubmed/?term=15585441 DMSYRBX DI DMSYRBX DMSYRBX DN Atazanavir DMSYRBX MI DE4LYSA DMSYRBX MN Cytochrome P450 3A4 (CYP3A4) DMSYRBX MT DME DMSYRBX MA Metabolism DMSYRBX RN Atazanavir: effects on P-glycoprotein transport and CYP3A metabolism in vitro. Drug Metab Dispos. 2005 Jun;33(6):764-70. DMSYRBX RU https://www.ncbi.nlm.nih.gov/pubmed/?term=15764714 DMSYRBX DI DMSYRBX DMSYRBX DN Atazanavir DMSYRBX MI DEIBDNY DMSYRBX MN Cytochrome P450 3A5 (CYP3A5) DMSYRBX MT DME DMSYRBX MA Metabolism DMSYRBX RN Atazanavir: effects on P-glycoprotein transport and CYP3A metabolism in vitro. Drug Metab Dispos. 2005 Jun;33(6):764-70. DMSYRBX RU https://www.ncbi.nlm.nih.gov/pubmed/?term=15764714 DMSYRBX DI DMSYRBX DMSYRBX DN Atazanavir DMSYRBX MI DERD86B DMSYRBX MN Cytochrome P450 3A7 (CYP3A7) DMSYRBX MT DME DMSYRBX MA Metabolism DMSYRBX RN Atazanavir: effects on P-glycoprotein transport and CYP3A metabolism in vitro. Drug Metab Dispos. 2005 Jun;33(6):764-70. DMSYRBX RU https://www.ncbi.nlm.nih.gov/pubmed/?term=15764714 DMSYRBX DI DMSYRBX DMSYRBX DN Atazanavir DMSYRBX MI TT5FNQT DMSYRBX MN Human immunodeficiency virus Protease (HIV PR) DMSYRBX MT DTT DMSYRBX MA Modulator DMSYRBX RN Hollow-fiber unit evaluation of a new human immunodeficiency virus type 1 protease inhibitor, BMS-232632, for determination of the linked pharmacod... J Infect Dis. 2001 Apr 1;183(7):1126-9. DMSYRBX RU https://pubmed.ncbi.nlm.nih.gov/11237841 DMSYRBX DI DMSYRBX DMSYRBX DN Atazanavir DMSYRBX MI DEYGVN4 DMSYRBX MN UDP-glucuronosyltransferase 1A1 (UGT1A1) DMSYRBX MT DME DMSYRBX MA Metabolism DMSYRBX RN In vitro inhibition of UDP glucuronosyltransferases by atazanavir and other HIV protease inhibitors and the relationship of this property to in vivo bilirubin glucuronidation. Drug Metab Dispos. 2005 Nov;33(11):1729-39. DMSYRBX RU https://www.ncbi.nlm.nih.gov/pubmed/?term=16118329 DMNKG1Z DI DMNKG1Z DMNKG1Z DN Atenolol DMNKG1Z MI TTR6W5O DMNKG1Z MN Adrenergic receptor beta-1 (ADRB1) DMNKG1Z MT DTT DMNKG1Z MA Antagonist DMNKG1Z RN Prediction and experimental validation of acute toxicity of beta-blockers in Ceriodaphnia dubia. Environ Toxicol Chem. 2005 Oct;24(10):2470-6. DMNKG1Z RU https://pubmed.ncbi.nlm.nih.gov/16268148 DMNKG1Z DI DMNKG1Z DMNKG1Z DN Atenolol DMNKG1Z MI DECB0K3 DMNKG1Z MN Cytochrome P450 2D6 (CYP2D6) DMNKG1Z MT DME DMNKG1Z MA Metabolism DMNKG1Z RN Application of substrate depletion assay to evaluation of CYP isoforms responsible for stereoselective metabolism of carvedilol. Drug Metab Pharmacokinet. 2016 Dec;31(6):425-432. DMNKG1Z RU https://www.ncbi.nlm.nih.gov/pubmed/?term=27836712 DMNKG1Z DI DMNKG1Z DMNKG1Z DN Atenolol DMNKG1Z MI DE4LYSA DMNKG1Z MN Cytochrome P450 3A4 (CYP3A4) DMNKG1Z MT DME DMNKG1Z MA Metabolism DMNKG1Z RN Metabolism of atenolol in man. Xenobiotica. 1978 May;8(5):313-20. DMNKG1Z RU https://www.ncbi.nlm.nih.gov/pubmed/?term=27019 DMNKG1Z DI DMNKG1Z DMNKG1Z DN Atenolol DMNKG1Z MI DTE2B1D DMNKG1Z MN Organic anion transporting polypeptide 1A2 (SLCO1A2) DMNKG1Z MT DTP DMNKG1Z MA Substrate DMNKG1Z RN Fruit juice inhibition of uptake transport: a new type of food-drug interaction. Br J Clin Pharmacol. 2010 Nov;70(5):645-55. DMNKG1Z RU http://www.ncbi.nlm.nih.gov/pubmed/21039758 DMNKG1Z DI DMNKG1Z DMNKG1Z DN Atenolol DMNKG1Z MI DTT79CX DMNKG1Z MN Organic cation transporter 1 (SLC22A1) DMNKG1Z MT DTP DMNKG1Z MA Substrate DMNKG1Z RN Identification of novel substrates and structure-activity relationship of cellular uptake mediated by human organic cation transporters 1 and 2. J Med Chem. 2013 Sep 26;56(18):7232-42. DMNKG1Z RU http://www.ncbi.nlm.nih.gov/pubmed/23984907 DMNKG1Z DI DMNKG1Z DMNKG1Z DN Atenolol DMNKG1Z MI DTUGYRD DMNKG1Z MN P-glycoprotein 1 (ABCB1) DMNKG1Z MT DTP DMNKG1Z MA Substrate DMNKG1Z RN Interaction of digoxin with antihypertensive drugs via MDR1. Life Sci. 2002 Feb 15;70(13):1491-500. DMNKG1Z RU http://www.ncbi.nlm.nih.gov/pubmed/11895100 DMMF8U0 DI DMMF8U0 DMMF8U0 DN Atezolizumab DMMF8U0 MI TT8ZLTI DMMF8U0 MN Programmed cell death 1 ligand 1 (PD-L1) DMMF8U0 MT DTT DMMF8U0 RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health Human Services. 2019 DMMF8U0 RU https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/761034s018lbl.pdf DM5L6HI DI DM5L6HI DM5L6HI DN Atomoxetine DM5L6HI MI DECB0K3 DM5L6HI MN Cytochrome P450 2D6 (CYP2D6) DM5L6HI MT DME DM5L6HI MA Metabolism DM5L6HI RN Atomoxetine: a review of its pharmacokinetics and pharmacogenomics relative to drug disposition. J Child Adolesc Psychopharmacol. 2016 May;26(4):314-26. DM5L6HI RU https://www.ncbi.nlm.nih.gov/pubmed/?term=26859445 DM5L6HI DI DM5L6HI DM5L6HI DN Atomoxetine DM5L6HI MI DEGTFWK DM5L6HI MN Mephenytoin 4-hydroxylase (CYP2C19) DM5L6HI MT DME DM5L6HI MA Metabolism DM5L6HI RN Atomoxetine: a review of its pharmacokinetics and pharmacogenomics relative to drug disposition. J Child Adolesc Psychopharmacol. 2016 May;26(4):314-26. DM5L6HI RU https://www.ncbi.nlm.nih.gov/pubmed/?term=26859445 DM5L6HI DI DM5L6HI DM5L6HI DN Atomoxetine DM5L6HI MI TTAWNKZ DM5L6HI MN Norepinephrine transporter (NET) DM5L6HI MT DTT DM5L6HI MA Inhibitor DM5L6HI RN Atomoxetine reverses attentional deficits produced by noradrenergic deafferentation of medial prefrontal cortex. Psychopharmacology (Berl). 2008 Sep;200(1):39-50. DM5L6HI RU https://pubmed.ncbi.nlm.nih.gov/18568443 DM5L6HI DI DM5L6HI DM5L6HI DN Atomoxetine DM5L6HI MI DTUGYRD DM5L6HI MN P-glycoprotein 1 (ABCB1) DM5L6HI MT DTP DM5L6HI MA Substrate DM5L6HI RN Improving the prediction of the brain disposition for orally administered drugs using BDDCS. Adv Drug Deliv Rev. 2012 Jan;64(1):95-109. DM5L6HI RU https://doi.org/10.1016/j.addr.2011.12.008 DMF28YC DI DMF28YC DMF28YC DN Atorvastatin DMF28YC MI DES5XRU DMF28YC MN Cytochrome P450 2C8 (CYP2C8) DMF28YC MT DME DMF28YC MA Metabolism DMF28YC RN Role of cytochrome P450 2C8 in drug metabolism and interactions. Pharmacol Rev. 2016 Jan;68(1):168-241. DMF28YC RU https://www.ncbi.nlm.nih.gov/pubmed/?term=26721703 DMF28YC DI DMF28YC DMF28YC DN Atorvastatin DMF28YC MI DE4LYSA DMF28YC MN Cytochrome P450 3A4 (CYP3A4) DMF28YC MT DME DMF28YC MA Metabolism DMF28YC RN Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. DMF28YC RU https://www.ncbi.nlm.nih.gov/pubmed/?term=19515014 DMF28YC DI DMF28YC DMF28YC DN Atorvastatin DMF28YC MI DEIBDNY DMF28YC MN Cytochrome P450 3A5 (CYP3A5) DMF28YC MT DME DMF28YC MA Metabolism DMF28YC RN Effects of acid and lactone forms of eight HMG-CoA reductase inhibitors on CYP-mediated metabolism and MDR1-mediated transport. Pharm Res. 2006 Mar;23(3):506-12. DMF28YC RU https://www.ncbi.nlm.nih.gov/pubmed/?term=16388406 DMF28YC DI DMF28YC DMF28YC DN Atorvastatin DMF28YC MI DERD86B DMF28YC MN Cytochrome P450 3A7 (CYP3A7) DMF28YC MT DME DMF28YC MA Metabolism DMF28YC RN Drug Development and Drug Interactions: Table of Substrates, Inhibitors and Inducers. DMF28YC RU https://www.fda.gov/Drugs/DevelopmentApprovalProcess/DevelopmentResources/DrugInteractionsLabeling/ucm093664.htm DMF28YC DI DMF28YC DMF28YC DN Atorvastatin DMF28YC MI TTPADOQ DMF28YC MN HMG-CoA reductase (HMGCR) DMF28YC MT DTT DMF28YC MA Inhibitor DMF28YC RN Equally potent inhibitors of cholesterol synthesis in human hepatocytes have distinguishable effects on different cytochrome P450 enzymes. Biopharm Drug Dispos. 2000 Dec;21(9):353-64. DMF28YC RU https://pubmed.ncbi.nlm.nih.gov/11523064 DMF28YC DI DMF28YC DMF28YC DN Atorvastatin DMF28YC MI DT342ZG DMF28YC MN Monocarboxylate transporter 1 (SLC16A1) DMF28YC MT DTP DMF28YC MA Substrate DMF28YC RN H+-coupled nutrient, micronutrient and drug transporters in the mammalian small intestine. Exp Physiol. 2007 Jul;92(4):603-19. DMF28YC RU https://doi.org/10.1113/expphysiol.2005.029959 DMF28YC DI DMF28YC DMF28YC DN Atorvastatin DMF28YC MI DTLT3UG DMF28YC MN Monocarboxylate transporter 2 (SLC16A7) DMF28YC MT DTP DMF28YC MA Substrate DMF28YC RN Monocarboxylate Transporters in Drug Disposition: Role in the Toxicokinetics and Toxicodynamics of the Drug of Abuse GHB. DMF28YC RU https://www.njacs.org/wp-content/docs/2010-Spring-DrugMet-Marilyn_Morris.pdf DMF28YC DI DMF28YC DMF28YC DN Atorvastatin DMF28YC MI DTE2B1D DMF28YC MN Organic anion transporting polypeptide 1A2 (SLCO1A2) DMF28YC MT DTP DMF28YC MA Substrate DMF28YC RN Influence of the flavonoids apigenin, kaempferol, and quercetin on the function of organic anion transporting polypeptides 1A2 and 2B1. Biochem Pharmacol. 2010 Dec 1;80(11):1746-53. DMF28YC RU http://www.ncbi.nlm.nih.gov/pubmed/20797388 DMF28YC DI DMF28YC DMF28YC DN Atorvastatin DMF28YC MI DT3D8F0 DMF28YC MN Organic anion transporting polypeptide 1B1 (SLCO1B1) DMF28YC MT DTP DMF28YC MA Substrate DMF28YC RN Rifampicin alters atorvastatin plasma concentration on the basis of SLCO1B1 521T>C polymorphism. Clin Chim Acta. 2009 Jul;405(1-2):49-52. DMF28YC RU http://www.ncbi.nlm.nih.gov/pubmed/19374892 DMF28YC DI DMF28YC DMF28YC DN Atorvastatin DMF28YC MI DT9C1TS DMF28YC MN Organic anion transporting polypeptide 1B3 (SLCO1B3) DMF28YC MT DTP DMF28YC MA Substrate DMF28YC RN FDA Drug Development and Drug Interactions DMF28YC RU https://www.fda.gov/drugs/developmentapprovalprocess/developmentresources/druginteractionslabeling/ucm093664.htm#table3-2 DMF28YC DI DMF28YC DMF28YC DN Atorvastatin DMF28YC MI DTPFTEQ DMF28YC MN Organic anion transporting polypeptide 2B1 (SLCO2B1) DMF28YC MT DTP DMF28YC MA Substrate DMF28YC RN Human platelets express organic anion-transporting peptide 2B1, an uptake transporter for atorvastatin. Drug Metab Dispos. 2009 May;37(5):1129-37. DMF28YC RU http://www.ncbi.nlm.nih.gov/pubmed/19237515 DMF28YC DI DMF28YC DMF28YC DN Atorvastatin DMF28YC MI DTUGYRD DMF28YC MN P-glycoprotein 1 (ABCB1) DMF28YC MT DTP DMF28YC MA Substrate DMF28YC RN Tarascon Pocket Pharmacopoeia 2018 Classic Shirt-Pocket Edition. DMF28YC RU https://books.google.com/books?id=0gBRDwAAQBAJ&pg=PP37&lpg=PP37&dq=Methylergonovine+transporter+uptake+efflex&source=bl&ots=cUTe_ppsmZ&sig=ACfU3U3E_YqrDg0CNEuj8K-7lci47HAnrg&hl=zh-CN&sa=X&ved=2ahUKEwjnj-Dk7d7iAhUsK6YKHd5DBDkQ6AEwEnoECAgQAQ#v=onepage&q&f=false DMF28YC DI DMF28YC DMF28YC DN Atorvastatin DMF28YC MI DEYGVN4 DMF28YC MN UDP-glucuronosyltransferase 1A1 (UGT1A1) DMF28YC MT DME DMF28YC MA Metabolism DMF28YC RN Atorvastatin glucuronidation is minimally and nonselectively inhibited by the fibrates gemfibrozil, fenofibrate, and fenofibric acid. Drug Metab Dispos. 2007 Aug;35(8):1315-24. DMF28YC RU https://www.ncbi.nlm.nih.gov/pubmed/?term=17470524 DMF28YC DI DMF28YC DMF28YC DN Atorvastatin DMF28YC MI DEF2WXN DMF28YC MN UDP-glucuronosyltransferase 1A3 (UGT1A3) DMF28YC MT DME DMF28YC MA Metabolism DMF28YC RN UGT1A1*28 is associated with decreased systemic exposure of atorvastatin lactone. Mol Diagn Ther. 2013 Aug;17(4):233-7. DMF28YC RU https://www.ncbi.nlm.nih.gov/pubmed/?term=23580084 DMY4UMW DI DMY4UMW DMY4UMW DN Atovaquone DMY4UMW MI DE4LYSA DMY4UMW MN Cytochrome P450 3A4 (CYP3A4) DMY4UMW MT DME DMY4UMW MA Metabolism DMY4UMW RN Time-dependent pharmacokinetics and drug metabolism of atovaquone plus proguanil (Malarone) when taken as chemoprophylaxis. Eur J Clin Pharmacol. 2002 Apr;58(1):19-27. DMY4UMW RU https://www.ncbi.nlm.nih.gov/pubmed/11956669 DMY4UMW DI DMY4UMW DMY4UMW DN Atovaquone DMY4UMW MI TT3PQ2Y DMY4UMW MN Plasmodium Dihydroorotate dehydrogenase (Malaria DHOdehase) DMY4UMW MT DTT DMY4UMW MA Inhibitor DMY4UMW RN Inhibitor binding in a class 2 dihydroorotate dehydrogenase causes variations in the membrane-associated N-terminal domain. Protein Sci. 2004 Apr;13(4):1031-42. DMY4UMW RU https://pubmed.ncbi.nlm.nih.gov/15044733 DM42HXN DI DM42HXN DM42HXN DN Atracurium DM42HXN MI TTJSZTB DM42HXN MN Nicotinic acetylcholine receptor (nAChR) DM42HXN MT DTT DM42HXN MA Antagonist DM42HXN RN Pharmacological characteristics of the inhibition of nondepolarizing neuromuscular blocking agents at human adult muscle nicotinic acetylcholine receptor. Anesthesiology. 2009 Jun;110(6):1244-52. DM42HXN RU https://pubmed.ncbi.nlm.nih.gov/19417616 DMEN6X7 DI DMEN6X7 DMEN6X7 DN Atropine DMEN6X7 MI TTH18TF DMEN6X7 MN Muscarinic acetylcholine receptor M5 (CHRM5) DMEN6X7 MT DTT DMEN6X7 MA Antagonist DMEN6X7 RN Additive protective effects of donepezil and nicotine against salsolinol-induced cytotoxicity in SH-SY5Y cells. Neurotox Res. 2009 Oct;16(3):194-204. DMEN6X7 RU https://pubmed.ncbi.nlm.nih.gov/19526284 DMEN6X7 DI DMEN6X7 DMEN6X7 DN Atropine DMEN6X7 MI DTT79CX DMEN6X7 MN Organic cation transporter 1 (SLC22A1) DMEN6X7 MT DTP DMEN6X7 MA Substrate DMEN6X7 RN Identification of novel substrates and structure-activity relationship of cellular uptake mediated by human organic cation transporters 1 and 2. J Med Chem. 2013 Sep 26;56(18):7232-42. DMEN6X7 RU http://www.ncbi.nlm.nih.gov/pubmed/23984907 DM79Y2T DI DM79Y2T DM79Y2T DN ATryn antithrombin DM79Y2T MI TT6L509 DM79Y2T MN Coagulation factor IIa (F2) DM79Y2T MT DTT DM79Y2T MA Modulator DM79Y2T RN Antithrombin III Utilization in a Large Teaching Hospital. P T. 2013 December; 38(12): 764-767, 779. DM79Y2T RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3875262/ DMWE2N4 DI DMWE2N4 DMWE2N4 DN Auranofin DMWE2N4 MI DTZGT0P DMWE2N4 MN Multidrug and toxin extrusion protein 1 (SLC47A1) DMWE2N4 MT DTP DMWE2N4 MA Substrate DMWE2N4 RN Selection and characterization of a human ovarian cancer cell line resistant to auranofin. Oncotarget. 2017 Oct 9;8(56):96062-96078. DMWE2N4 RU http://www.ncbi.nlm.nih.gov/pubmed/29221187 DMWE2N4 DI DMWE2N4 DMWE2N4 DN Auranofin DMWE2N4 MI DTT79CX DMWE2N4 MN Organic cation transporter 1 (SLC22A1) DMWE2N4 MT DTP DMWE2N4 MA Substrate DMWE2N4 RN Selection and characterization of a human ovarian cancer cell line resistant to auranofin. Oncotarget. 2017 Oct 9;8(56):96062-96078. DMWE2N4 RU http://www.ncbi.nlm.nih.gov/pubmed/29221187 DMWE2N4 DI DMWE2N4 DMWE2N4 DN Auranofin DMWE2N4 MI TTP3UTW DMWE2N4 MN Steroid hormone receptor ERR (ESRR) DMWE2N4 MT DTT DMWE2N4 MA Modulator DMWE2N4 RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. DMWE2N4 RU https://www.fda.gov/ DM75CXN DI DM75CXN DM75CXN DN Avanafil DM75CXN MI DE4LYSA DM75CXN MN Cytochrome P450 3A4 (CYP3A4) DM75CXN MT DME DM75CXN MA Metabolism DM75CXN RN An update on pharmacological treatment of erectile dysfunction with phosphodiesterase type 5 inhibitors. Expert Opin Pharmacother. 2013 Jul;14(10):1333-44. DM75CXN RU https://www.ncbi.nlm.nih.gov/pubmed/?term=23675780 DM75CXN DI DM75CXN DM75CXN DN Avanafil DM75CXN MI TTJ0IQB DM75CXN MN Phosphodiesterase 5A (PDE5A) DM75CXN MT DTT DM75CXN MA Modulator DM75CXN RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015 DM75CXN RU https://www.accessdata.fda.gov/scripts/cder/drugsatfda/ DMK2GZX DI DMK2GZX DMK2GZX DN Avapritinib DMK2GZX MI TT8FYO9 DMK2GZX MN Platelet-derived growth factor receptor alpha (PDGFRA) DMK2GZX MT DTT DMK2GZX MA Inhibitor DMK2GZX RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health Human Services. 2020 DMK2GZX RU https://www.accessdata.fda.gov/drugsatfda_docs/label/2020/212608s000lbl.pdf DMSZLJR DI DMSZLJR DMSZLJR DN Avelumab DMSZLJR MI TT8ZLTI DMSZLJR MN Programmed cell death 1 ligand 1 (PD-L1) DMSZLJR MT DTT DMSZLJR RN Antibody-Dependent Cellular Cytotoxicity Activity of a Novel Anti-PD-L1 Antibody Avelumab (MSB0010718C) on Human Tumor Cells. Cancer Immunol Res. 2015 Oct;3(10):1148-57. DMSZLJR RU https://pubmed.ncbi.nlm.nih.gov/26014098 DM1AEH4 DI DM1AEH4 DM1AEH4 DN Avibactam DM1AEH4 MI DE7IH52 DM1AEH4 MN Beta-lactamase (blaB) DM1AEH4 MT DME DM1AEH4 MA Metabolism DM1AEH4 RN nan DM1AEH4 RU nan DMYHN59 DI DMYHN59 DMYHN59 DN Axicabtagene ciloleucel DMYHN59 MI TTW640A DMYHN59 MN B-lymphocyte surface antigen B4 (CD19) DMYHN59 MT DTT DMYHN59 MA CAR-T-Cell-Therapy DMYHN59 RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health Human Services DMYHN59 RU https://www.fda.gov/vaccines-blood-biologics/cellular-gene-therapy-products/yescarta-axicabtagene-ciloleucel DMGVH6N DI DMGVH6N DMGVH6N DN Axitinib DMGVH6N MI DEJGDUW DMGVH6N MN Cytochrome P450 1A2 (CYP1A2) DMGVH6N MT DME DMGVH6N MA Metabolism DMGVH6N RN Clinical pharmacology of axitinib. Clin Pharmacokinet. 2013 Sep;52(9):713-25. DMGVH6N RU https://www.ncbi.nlm.nih.gov/pubmed/?term=23677771 DMGVH6N DI DMGVH6N DMGVH6N DN Axitinib DMGVH6N MI DE4LYSA DMGVH6N MN Cytochrome P450 3A4 (CYP3A4) DMGVH6N MT DME DMGVH6N MA Metabolism DMGVH6N RN Clinical pharmacology of axitinib. Clin Pharmacokinet. 2013 Sep;52(9):713-25. DMGVH6N RU https://www.ncbi.nlm.nih.gov/pubmed/?term=23677771 DMGVH6N DI DMGVH6N DMGVH6N DN Axitinib DMGVH6N MI DEIBDNY DMGVH6N MN Cytochrome P450 3A5 (CYP3A5) DMGVH6N MT DME DMGVH6N MA Metabolism DMGVH6N RN Clinical pharmacology of axitinib. Clin Pharmacokinet. 2013 Sep;52(9):713-25. DMGVH6N RU https://www.ncbi.nlm.nih.gov/pubmed/?term=23677771 DMGVH6N DI DMGVH6N DMGVH6N DN Axitinib DMGVH6N MI DEGTFWK DMGVH6N MN Mephenytoin 4-hydroxylase (CYP2C19) DMGVH6N MT DME DMGVH6N MA Metabolism DMGVH6N RN Clinical pharmacology of axitinib. Clin Pharmacokinet. 2013 Sep;52(9):713-25. DMGVH6N RU https://www.ncbi.nlm.nih.gov/pubmed/?term=23677771 DMGVH6N DI DMGVH6N DMGVH6N DN Axitinib DMGVH6N MI DT3D8F0 DMGVH6N MN Organic anion transporting polypeptide 1B1 (SLCO1B1) DMGVH6N MT DTP DMGVH6N MA Substrate DMGVH6N RN Meta-analysis of contribution of genetic polymorphisms in drug-metabolizing enzymes or transporters to axitinib pharmacokinetics. Eur J Clin Pharmacol. 2012 May;68(5):645-55. DMGVH6N RU http://www.ncbi.nlm.nih.gov/pubmed/22170007 DMGVH6N DI DMGVH6N DMGVH6N DN Axitinib DMGVH6N MI DTUGYRD DMGVH6N MN P-glycoprotein 1 (ABCB1) DMGVH6N MT DTP DMGVH6N MA Substrate DMGVH6N RN Meta-analysis of contribution of genetic polymorphisms in drug-metabolizing enzymes or transporters to axitinib pharmacokinetics. Eur J Clin Pharmacol. 2012 May;68(5):645-55. DMGVH6N RU http://www.ncbi.nlm.nih.gov/pubmed/22170007 DMGVH6N DI DMGVH6N DMGVH6N DN Axitinib DMGVH6N MI DEYGVN4 DMGVH6N MN UDP-glucuronosyltransferase 1A1 (UGT1A1) DMGVH6N MT DME DMGVH6N MA Metabolism DMGVH6N RN Clinical pharmacology of axitinib. Clin Pharmacokinet. 2013 Sep;52(9):713-25. DMGVH6N RU https://www.ncbi.nlm.nih.gov/pubmed/?term=23677771 DMGVH6N DI DMGVH6N DMGVH6N DN Axitinib DMGVH6N MI TTUTJGQ DMGVH6N MN Vascular endothelial growth factor receptor 2 (KDR) DMGVH6N MT DTT DMGVH6N MA Modulator DMGVH6N RN Nat Rev Drug Discov. 2013 Feb;12(2):87-90. DMGVH6N RU https://pubmed.ncbi.nlm.nih.gov/23370234 DMTA5OE DI DMTA5OE DMTA5OE DN Azacitidine DMTA5OE MI DEKEDRC DMTA5OE MN Cytidine aminohydrolase (CDA) DMTA5OE MT DME DMTA5OE MA Metabolism DMTA5OE RN A pilot pharmacokinetic study of oral azacitidine. Leukemia. 2008 Sep;22(9):1680-4. DMTA5OE RU https://www.ncbi.nlm.nih.gov/pubmed/?term=18548103 DMTA5OE DI DMTA5OE DMTA5OE DN Azacitidine DMTA5OE MI DEYILK4 DMTA5OE MN Cytidine deaminase (cdd) DMTA5OE MT DME DMTA5OE MA Metabolism DMTA5OE RN Mycoplasma hyorhinis-encoded cytidine deaminase efficiently inactivates cytosine-based anticancer drugs. FEBS Open Bio. 2015 Aug 3;5:634-9. DMTA5OE RU https://pubmed.ncbi.nlm.nih.gov/26322268 DMTA5OE DI DMTA5OE DMTA5OE DN Azacitidine DMTA5OE MI TTHVCUP DMTA5OE MN DNA [cytosine-5]-methyltransferase (DNMT) DMTA5OE MT DTT DMTA5OE MA Inhibitor DMTA5OE RN The DNA methyltransferase inhibitors azacitidine, decitabine and zebularine exert differential effects on cancer gene expression in acute myeloid l... Leukemia. 2009 Jun;23(6):1019-28. DMTA5OE RU https://pubmed.ncbi.nlm.nih.gov/19194470 DMZ80SB DI DMZ80SB DMZ80SB DN Azatadine DMZ80SB MI TTTIBOJ DMZ80SB MN Histamine H1 receptor (H1R) DMZ80SB MT DTT DMZ80SB MA Antagonist DMZ80SB RN Comparative effects of loratadine and azatadine in the treatment of seasonal allergic rhinitis. Asian Pac J Allergy Immunol. 1990 Dec;8(2):103-7. DMZ80SB RU https://pubmed.ncbi.nlm.nih.gov/1982614 DMMZSXQ DI DMMZSXQ DMMZSXQ DN Azathioprine DMMZSXQ MI TTZFTY4 DMMZSXQ MN Amidophosphoribosyltransferase (PPAT) DMMZSXQ MT DTT DMMZSXQ MA Inhibitor DMMZSXQ RN IMPDH activity in thiopurine-treated patients with inflammatory bowel disease - relation to TPMT activity and metabolite concentrations. Br J Clin Pharmacol. 2008 Jan;65(1):69-77. DMMZSXQ RU https://pubmed.ncbi.nlm.nih.gov/17662091 DMMZSXQ DI DMMZSXQ DMMZSXQ DN Azathioprine DMMZSXQ MI DEJGDUW DMMZSXQ MN Cytochrome P450 1A2 (CYP1A2) DMMZSXQ MT DME DMMZSXQ MA Metabolism DMMZSXQ RN Brassica vegetables increase and apiaceous vegetables decrease cytochrome P450 1A2 activity in humans: changes in caffeine metabolite ratios in response to controlled vegetable diets. Carcinogenesis. 2000 Jun;21(6):1157-62. DMMZSXQ RU https://www.ncbi.nlm.nih.gov/pubmed/?term=10837004 DMMZSXQ DI DMMZSXQ DMMZSXQ DN Azathioprine DMMZSXQ MI DEH49YS DMMZSXQ MN Glutathione S-transferase alpha-2 (GSTA2) DMMZSXQ MT DME DMMZSXQ MA Metabolism DMMZSXQ RN PharmGKB: A worldwide resource for pharmacogenomic information. Wiley Interdiscip Rev Syst Biol Med. 2018 Jul;10(4):e1417. (ID: PA2040) DMMZSXQ RU https://www.pharmgkb.org/pathway/PA2040 DMMZSXQ DI DMMZSXQ DMMZSXQ DN Azathioprine DMMZSXQ MI DEYZEJA DMMZSXQ MN Glutathione S-transferase mu-1 (GSTM1) DMMZSXQ MT DME DMMZSXQ MA Metabolism DMMZSXQ RN PharmGKB: A worldwide resource for pharmacogenomic information. Wiley Interdiscip Rev Syst Biol Med. 2018 Jul;10(4):e1417. (ID: PA2040) DMMZSXQ RU https://www.pharmgkb.org/pathway/PA2040 DMMZSXQ DI DMMZSXQ DMMZSXQ DN Azathioprine DMMZSXQ MI DTUGYRD DMMZSXQ MN P-glycoprotein 1 (ABCB1) DMMZSXQ MT DTP DMMZSXQ MA Substrate DMMZSXQ RN Caco-2 permeability, P-glycoprotein transport ratios and brain penetration of heterocyclic drugs. Int J Pharm. 2003 Sep 16;263(1-2):113-22. DMMZSXQ RU http://www.ncbi.nlm.nih.gov/pubmed/12954186 DMMZSXQ DI DMMZSXQ DMMZSXQ DN Azathioprine DMMZSXQ MI DEFQ8VO DMMZSXQ MN Thiopurine methyltransferase (TPMT) DMMZSXQ MT DME DMMZSXQ MA Metabolism DMMZSXQ RN Nodular regenerative liver hyperplasia as a complication of azathioprine-containing immunosuppressive treatment for Crohn's disease. Immunopharmacol Immunotoxicol. 2011 Jun;33(2):398-402. DMMZSXQ RU https://www.ncbi.nlm.nih.gov/pubmed/?term=20726808 DMHVL0J DI DMHVL0J DMHVL0J DN Azelaic Acid DMHVL0J MI TT2A0DR DMHVL0J MN Oxo-5-alpha-steroid 4-dehydrogenase (SRD5A) DMHVL0J MT DTT DMHVL0J MA Inhibitor DMHVL0J RN Inhibition of 5 alpha-reductase activity in human skin by zinc and azelaic acid. Br J Dermatol. 1988 Nov;119(5):627-32. DMHVL0J RU https://pubmed.ncbi.nlm.nih.gov/3207614 DMXTMBJ DI DMXTMBJ DMXTMBJ DN Azelastine DMXTMBJ MI DEJGDUW DMXTMBJ MN Cytochrome P450 1A2 (CYP1A2) DMXTMBJ MT DME DMXTMBJ MA Metabolism DMXTMBJ RN In vitro identification of the human cytochrome P-450 enzymes involved in the N-demethylation of azelastine. Drug Metab Dispos. 1999 Aug;27(8):942-6. DMXTMBJ RU https://www.ncbi.nlm.nih.gov/pubmed/?term=10421623 DMXTMBJ DI DMXTMBJ DMXTMBJ DN Azelastine DMXTMBJ MI DEJVYAZ DMXTMBJ MN Cytochrome P450 2A6 (CYP2A6) DMXTMBJ MT DME DMXTMBJ MA Metabolism DMXTMBJ RN Azelastine N-demethylation by cytochrome P-450 (CYP)3A4, CYP2D6, and CYP1A2 in human liver microsomes: evaluation of approach to predict the contribution of multiple CYPs. Drug Metab Dispos. 1999 Dec;27(12):1381-91. DMXTMBJ RU https://www.ncbi.nlm.nih.gov/pubmed/?term=10570018 DMXTMBJ DI DMXTMBJ DMXTMBJ DN Azelastine DMXTMBJ MI DES5XRU DMXTMBJ MN Cytochrome P450 2C8 (CYP2C8) DMXTMBJ MT DME DMXTMBJ MA Metabolism DMXTMBJ RN Azelastine N-demethylation by cytochrome P-450 (CYP)3A4, CYP2D6, and CYP1A2 in human liver microsomes: evaluation of approach to predict the contribution of multiple CYPs. Drug Metab Dispos. 1999 Dec;27(12):1381-91. DMXTMBJ RU https://www.ncbi.nlm.nih.gov/pubmed/?term=10570018 DMXTMBJ DI DMXTMBJ DMXTMBJ DN Azelastine DMXTMBJ MI DE5IED8 DMXTMBJ MN Cytochrome P450 2C9 (CYP2C9) DMXTMBJ MT DME DMXTMBJ MA Metabolism DMXTMBJ RN Azelastine N-demethylation by cytochrome P-450 (CYP)3A4, CYP2D6, and CYP1A2 in human liver microsomes: evaluation of approach to predict the contribution of multiple CYPs. Drug Metab Dispos. 1999 Dec;27(12):1381-91. DMXTMBJ RU https://www.ncbi.nlm.nih.gov/pubmed/?term=10570018 DMXTMBJ DI DMXTMBJ DMXTMBJ DN Azelastine DMXTMBJ MI DECB0K3 DMXTMBJ MN Cytochrome P450 2D6 (CYP2D6) DMXTMBJ MT DME DMXTMBJ MA Metabolism DMXTMBJ RN Inhibitory effects of azelastine and its metabolites on drug oxidation catalyzed by human cytochrome P-450 enzymes. Drug Metab Dispos. 1999 Jul;27(7):792-7. DMXTMBJ RU https://www.ncbi.nlm.nih.gov/pubmed/?term=10383922 DMXTMBJ DI DMXTMBJ DMXTMBJ DN Azelastine DMXTMBJ MI DE4LYSA DMXTMBJ MN Cytochrome P450 3A4 (CYP3A4) DMXTMBJ MT DME DMXTMBJ MA Metabolism DMXTMBJ RN In vitro identification of the human cytochrome P-450 enzymes involved in the N-demethylation of azelastine. Drug Metab Dispos. 1999 Aug;27(8):942-6. DMXTMBJ RU https://www.ncbi.nlm.nih.gov/pubmed/?term=10421623 DMXTMBJ DI DMXTMBJ DMXTMBJ DN Azelastine DMXTMBJ MI DEIBDNY DMXTMBJ MN Cytochrome P450 3A5 (CYP3A5) DMXTMBJ MT DME DMXTMBJ MA Metabolism DMXTMBJ RN Azelastine N-demethylation by cytochrome P-450 (CYP)3A4, CYP2D6, and CYP1A2 in human liver microsomes: evaluation of approach to predict the contribution of multiple CYPs. Drug Metab Dispos. 1999 Dec;27(12):1381-91. DMXTMBJ RU https://www.ncbi.nlm.nih.gov/pubmed/?term=10570018 DMXTMBJ DI DMXTMBJ DMXTMBJ DN Azelastine DMXTMBJ MI TTTIBOJ DMXTMBJ MN Histamine H1 receptor (H1R) DMXTMBJ MT DTT DMXTMBJ MA Antagonist DMXTMBJ RN Intact cell binding for in vitro prediction of sedative and non-sedative histamine H1-receptor antagonists based on receptor internalization. J Pharmacol Sci. 2008 May;107(1):66-79. DMXTMBJ RU https://pubmed.ncbi.nlm.nih.gov/18446005 DMXTMBJ DI DMXTMBJ DMXTMBJ DN Azelastine DMXTMBJ MI DEGTFWK DMXTMBJ MN Mephenytoin 4-hydroxylase (CYP2C19) DMXTMBJ MT DME DMXTMBJ MA Metabolism DMXTMBJ RN In vitro identification of the human cytochrome P-450 enzymes involved in the N-demethylation of azelastine. Drug Metab Dispos. 1999 Aug;27(8):942-6. DMXTMBJ RU https://www.ncbi.nlm.nih.gov/pubmed/?term=10421623 DMOIX5S DI DMOIX5S DMOIX5S DN Azilsartan DMOIX5S MI TT8DBY3 DMOIX5S MN Angiotensin II receptor type-1 (AGTR1) DMOIX5S MT DTT DMOIX5S MA Modulator DMOIX5S RN 2011 FDA drug approvals. Nat Rev Drug Discov. 2012 Feb 1;11(2):91-4. DMOIX5S RU https://pubmed.ncbi.nlm.nih.gov/22293555 DMIR5QP DI DMIR5QP DMIR5QP DN Azlocillin DMIR5QP MI TTJP4SM DMIR5QP MN Bacterial Penicillin binding protein (Bact PBP) DMIR5QP MT DTT DMIR5QP MA Binder DMIR5QP RN Reactivation of peptidoglycan synthesis in ether-permeabilized Escherichia coli after inhibition by beta-lactam antibiotics. Antimicrob Agents Chemother. 1989 Dec;33(12):2101-8. DMIR5QP RU https://pubmed.ncbi.nlm.nih.gov/2515794 DMDNJHG DI DMDNJHG DMDNJHG DN Aztreonam DMDNJHG MI TT85JMW DMDNJHG MN Bacterial Penicillin binding protein 3 (Bact mrcA) DMDNJHG MT DTT DMDNJHG MA Binder DMDNJHG RN Penicillin-binding protein PBP2 of Escherichia coli localizes preferentially in the lateral wall and at mid-cell in comparison with the old cell pole. Mol Microbiol. 2003 Jan;47(2):539-47. DMDNJHG RU https://pubmed.ncbi.nlm.nih.gov/12519203 DMDNJHG DI DMDNJHG DMDNJHG DN Aztreonam DMDNJHG MI DEP0IWS DMDNJHG MN Beta-lactamase (blaB) DMDNJHG MT DME DMDNJHG MA Metabolism DMDNJHG RN Analysis of the drug-resistant characteristics of Klebsiella pneumoniae isolated from the respiratory tract and CTX-M ESBL genes. Genet Mol Res. 2015 Oct 5;14(4):12043-8. DMDNJHG RU https://pubmed.ncbi.nlm.nih.gov/26505351 DMDNJHG DI DMDNJHG DMDNJHG DN Aztreonam DMDNJHG MI DEEAL81 DMDNJHG MN Beta-lactamase (blaB) DMDNJHG MT DME DMDNJHG MA Metabolism DMDNJHG RN Antibiotic resistance and production of extended-spectrum beta-lactamases amongst Klebsiella spp. from intensive care units in Europe. J Antimicrob Chemother. 1996 Sep;38(3):409-24. DMDNJHG RU https://pubmed.ncbi.nlm.nih.gov/8889716 DMDNJHG DI DMDNJHG DMDNJHG DN Aztreonam DMDNJHG MI DE4LYSA DMDNJHG MN Cytochrome P450 3A4 (CYP3A4) DMDNJHG MT DME DMDNJHG MA Metabolism DMDNJHG RN Aztreonam decreases hepatic microsomal cytochrome P450 in cynomolgus monkeys. Pharmacology. 1994 Mar;48(3):137-42. DMDNJHG RU https://www.ncbi.nlm.nih.gov/pubmed/?term=8153141 DMDNJHG DI DMDNJHG DMDNJHG DN Aztreonam DMDNJHG MI DEIBDNY DMDNJHG MN Cytochrome P450 3A5 (CYP3A5) DMDNJHG MT DME DMDNJHG MA Metabolism DMDNJHG RN Aztreonam decreases hepatic microsomal cytochrome P450 in cynomolgus monkeys. Pharmacology. 1994 Mar;48(3):137-42. DMDNJHG RU https://www.ncbi.nlm.nih.gov/pubmed/?term=8153141 DMDNJHG DI DMDNJHG DMDNJHG DN Aztreonam DMDNJHG MI DERD86B DMDNJHG MN Cytochrome P450 3A7 (CYP3A7) DMDNJHG MT DME DMDNJHG MA Metabolism DMDNJHG RN Aztreonam decreases hepatic microsomal cytochrome P450 in cynomolgus monkeys. Pharmacology. 1994 Mar;48(3):137-42. DMDNJHG RU https://www.ncbi.nlm.nih.gov/pubmed/?term=8153141 DMP54C7 DI DMP54C7 DMP54C7 DN Bacampicillin DMP54C7 MI TTJP4SM DMP54C7 MN Bacterial Penicillin binding protein (Bact PBP) DMP54C7 MT DTT DMP54C7 MA Binder DMP54C7 RN Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. DMP54C7 RU https://pubmed.ncbi.nlm.nih.gov/17016423 DMD2871 DI DMD2871 DMD2871 DN Bacitracin DMD2871 MI DEK9LVM DMD2871 MN Endoglucanase A (EGA) DMD2871 MT DME DMD2871 MA Metabolism DMD2871 RN Expression of Clostridium thermocellum endoglucanase gene in Lactobacillus gasseri and Lactobacillus johnsonii and characterization of the genetically modified probiotic lactobacilli. Curr Microbiol. 2000 Apr;40(4):257-63. DMD2871 RU https://pubmed.ncbi.nlm.nih.gov/10688695 DMD2871 DI DMD2871 DMD2871 DN Bacitracin DMD2871 MI DE2M583 DMD2871 MN Endoglucanase Y (EGY) DMD2871 MT DME DMD2871 MA Metabolism DMD2871 RN Expression of Clostridium thermocellum endoglucanase gene in Lactobacillus gasseri and Lactobacillus johnsonii and characterization of the genetically modified probiotic lactobacilli. Curr Microbiol. 2000 Apr;40(4):257-63. DMD2871 RU https://pubmed.ncbi.nlm.nih.gov/10688695 DM5OHYE DI DM5OHYE DM5OHYE DN Bacitracin DM5OHYE MI TT2EDHU DM5OHYE MN Insulin-degrading enzyme (IDE) DM5OHYE MT DTT DM5OHYE MA Inhibitor DM5OHYE RN Brain insulin impairs amyloid-beta(1-40) clearance from the brain. J Neurosci. 2004 Oct 27;24(43):9632-7. DM5OHYE RU https://pubmed.ncbi.nlm.nih.gov/15509750 DM0QV1J DI DM0QV1J DM0QV1J DN Baclofen DM0QV1J MI TTDCVZW DM0QV1J MN Gamma-aminobutyric acid B receptor (GABBR) DM0QV1J MT DTT DM0QV1J MA Modulator DM0QV1J RN Synthesis and pharmacology of the baclofen homologues 5-amino-4-(4-chlorophenyl)pentanoic acid and the R- and S-enantiomers of 5-amino-3-(4-chlorop... J Med Chem. 1999 Jun 3;42(11):2053-9. DM0QV1J RU https://pubmed.ncbi.nlm.nih.gov/10354414 DMPWNDB DI DMPWNDB DMPWNDB DN Balofloxacin DMPWNDB MI TTJP4SM DMPWNDB MN Bacterial Penicillin binding protein (Bact PBP) DMPWNDB MT DTT DMPWNDB MA Inhibitor DMPWNDB RN Emerging drugs for bacterial urinary tract infections. Expert Opin Emerg Drugs. 2005 May;10(2):275-98. DMPWNDB RU https://pubmed.ncbi.nlm.nih.gov/15934867 DM1UV7F DI DM1UV7F DM1UV7F DN Baloxavir marboxil DM1UV7F MI DE4LYSA DM1UV7F MN Cytochrome P450 3A4 (CYP3A4) DM1UV7F MT DME DM1UV7F MA Metabolism DM1UV7F RN FDA Label of Baloxavir marboxil. The 2020 official website of the U.S. Food and Drug Administration. DM1UV7F RU https://www.accessdata.fda.gov/drugsatfda_docs/label/2018/210854s000lbl.pdf DM1UV7F DI DM1UV7F DM1UV7F DN Baloxavir marboxil DM1UV7F MI TTWORX6 DM1UV7F MN Influenza Polymerase acidic endonuclease (Influ PA) DM1UV7F MT DTT DM1UV7F MA Inhibitor DM1UV7F RN 2018 FDA drug approvals.Nat Rev Drug Discov. 2019 Feb;18(2):85-89. DM1UV7F RU https://pubmed.ncbi.nlm.nih.gov/30710142 DMRJ9EN DI DMRJ9EN DMRJ9EN DN Baloxavir marboxil DMRJ9EN MI DTUGYRD DMRJ9EN MN P-glycoprotein 1 (ABCB1) DMRJ9EN MT DTP DMRJ9EN MA Substrate DMRJ9EN RN Baloxavir Marboxil FDA label DMRJ9EN RU https://s3-us-west-2.amazonaws.com/drugbank/cite_this/attachments/files/000/002/078/original/Baloxavir_Marboxil_FDA_label.pdf?1543255968 DM1UV7F DI DM1UV7F DM1UV7F DN Baloxavir marboxil DM1UV7F MI DEF2WXN DM1UV7F MN UDP-glucuronosyltransferase 1A3 (UGT1A3) DM1UV7F MT DME DM1UV7F MA Metabolism DM1UV7F RN FDA Label of Baloxavir marboxil. The 2020 official website of the U.S. Food and Drug Administration. DM1UV7F RU https://www.accessdata.fda.gov/drugsatfda_docs/label/2018/210854s000lbl.pdf DM7I1T9 DI DM7I1T9 DM7I1T9 DN Balsalazide DM7I1T9 MI DEEHWOG DM7I1T9 MN Azoreductase (azoR) DM7I1T9 MT DME DM7I1T9 MA Metabolism DM7I1T9 RN Studies of two novel sulfasalazine analogs, ipsalazide and balsalazide. Dig Dis Sci. 1983 Jul;28(7):609-15. DM7I1T9 RU https://pubmed.ncbi.nlm.nih.gov/6345112 DM7I1T9 DI DM7I1T9 DM7I1T9 DN Balsalazide DM7I1T9 MI DETQAEP DM7I1T9 MN FMN-dependent NADH-azoreductase (azoR1) DM7I1T9 MT DME DM7I1T9 MA Metabolism DM7I1T9 RN nan DM7I1T9 RU nan DMO091F DI DMO091F DMO091F DN Balsalazide DMO091F MI TT8NGED DMO091F MN Prostaglandin G/H synthase 1 (COX-1) DMO091F MT DTT DMO091F MA Inhibitor DMO091F RN Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. DMO091F RU https://pubmed.ncbi.nlm.nih.gov/17016423 DMKLSHF DI DMKLSHF DMKLSHF DN Bambuterol DMKLSHF MI TT2CJVK DMKLSHF MN Adrenergic receptor beta-2 (ADRB2) DMKLSHF MT DTT DMKLSHF MA Agonist DMKLSHF RN Enantiomeric separation of beta2-agonists on macrocyclic antibiotic chiral stationary phases in high performance liquid chromatography. Pharmazie. 2007 Nov;62(11):836-40. DMKLSHF RU https://pubmed.ncbi.nlm.nih.gov/18065099 DMXLHYN DI DMXLHYN DMXLHYN DN Bamifylline DMXLHYN MI DEJGDUW DMXLHYN MN Cytochrome P450 1A2 (CYP1A2) DMXLHYN MT DME DMXLHYN MA Metabolism DMXLHYN RN PharmGKB summary: caffeine pathway. Pharmacogenet Genomics. 2012 May;22(5):389-95. DMXLHYN RU https://www.ncbi.nlm.nih.gov/pubmed/?term=22293536 DME1DJX DI DME1DJX DME1DJX DN Baquting DME1DJX MI TTWODQF DME1DJX MN Fibrin (FG) DME1DJX MT DTT DME1DJX MA Modulator DME1DJX RN Baquting, enable our sales and marketing team to effectively promote our principal products and help to stimulate the sales of our other pharmaceuticals. DME1DJX RU http://www.sec.gov/Archives/edgar/data/1474952/000119312509239183/df1.htm DMJ8NMC DI DMJ8NMC DMJ8NMC DN Barbital DMJ8NMC MI TT1MPAY DMJ8NMC MN GABA(A) receptor alpha-1 (GABRA1) DMJ8NMC MT DTT DMJ8NMC MA Antagonist DMJ8NMC RN DrugBank: a knowledgebase for drugs, drug actions and drug targets. Nucleic Acids Res. 2008 Jan;36(Database issue):D901-6. DMJ8NMC RU https://pubmed.ncbi.nlm.nih.gov/18048412 DMJ8NMC DI DMJ8NMC DMJ8NMC DN Barbital DMJ8NMC MI DEGTFWK DMJ8NMC MN Mephenytoin 4-hydroxylase (CYP2C19) DMJ8NMC MT DME DMJ8NMC MA Metabolism DMJ8NMC RN Effects of cytochrome P450 (CYP)2C19 polymorphisms on pharmacokinetics of phenobarbital in neonates and infants with seizures. Arch Dis Child. 2012 Jun;97(6):569-72. DMJ8NMC RU https://www.ncbi.nlm.nih.gov/pubmed/?term=22331680 DMJIA6T DI DMJIA6T DMJIA6T DN Barbiturate DMJIA6T MI TT1MPAY DMJIA6T MN GABA(A) receptor alpha-1 (GABRA1) DMJIA6T MT DTT DMJIA6T MA Antagonist DMJIA6T RN DrugBank: a knowledgebase for drugs, drug actions and drug targets. Nucleic Acids Res. 2008 Jan;36(Database issue):D901-6. DMJIA6T RU https://pubmed.ncbi.nlm.nih.gov/18048412 DMJIA6T DI DMJIA6T DMJIA6T DN Barbiturate DMJIA6T MI TTAN6JD DMJIA6T MN Glutamate receptor AMPA (GRIA) DMJIA6T MT DTT DMJIA6T MA Agonist DMJIA6T RN Anaesthetic drugs: linking molecular actions to clinical effects. Curr Pharm Des. 2006;12(28):3665-79. DMJIA6T RU https://pubmed.ncbi.nlm.nih.gov/17073666 DM4ONW5 DI DM4ONW5 DM4ONW5 DN Baricitinib DM4ONW5 MI DTI7UX6 DM4ONW5 MN Breast cancer resistance protein (ABCG2) DM4ONW5 MT DTP DM4ONW5 MA Substrate DM4ONW5 RN Differential Influence of the Antiretroviral Pharmacokinetic Enhancers Ritonavir and Cobicistat on Intestinal P-Glycoprotein Transport and the Pharmacokinetic/Pharmacodynamic Disposition of Dabigatran. Antimicrob Agents Chemother. 2017 Oct 24;61(11). pii: e01201-17. DM4ONW5 RU http://www.ncbi.nlm.nih.gov/pubmed/28848011 DM4ONW5 DI DM4ONW5 DM4ONW5 DN Baricitinib DM4ONW5 MI DE4LYSA DM4ONW5 MN Cytochrome P450 3A4 (CYP3A4) DM4ONW5 MT DME DM4ONW5 MA Metabolism DM4ONW5 RN FDA label of Baricitinib. The 2020 official website of the U.S. Food and Drug Administration. DM4ONW5 RU https://www.accessdata.fda.gov/drugsatfda_docs/label/2018/207924s000lbl.pdf DM4ONW5 DI DM4ONW5 DM4ONW5 DN Baricitinib DM4ONW5 MI TT6DM01 DM4ONW5 MN Janus kinase 1 (JAK-1) DM4ONW5 MT DTT DM4ONW5 MA Modulator DM4ONW5 RN Selective JAK inhibitors in development for rheumatoid arthritis. Expert Opin Investig Drugs. 2014 Aug;23(8):1067-77. DM4ONW5 RU https://pubmed.ncbi.nlm.nih.gov/24818516 DM4ONW5 DI DM4ONW5 DM4ONW5 DN Baricitinib DM4ONW5 MI TTRMX3V DM4ONW5 MN Janus kinase 2 (JAK-2) DM4ONW5 MT DTT DM4ONW5 MA Modulator DM4ONW5 RN Selective JAK inhibitors in development for rheumatoid arthritis. Expert Opin Investig Drugs. 2014 Aug;23(8):1067-77. DM4ONW5 RU https://pubmed.ncbi.nlm.nih.gov/24818516 DM4ONW5 DI DM4ONW5 DM4ONW5 DN Baricitinib DM4ONW5 MI DTUGYRD DM4ONW5 MN P-glycoprotein 1 (ABCB1) DM4ONW5 MT DTP DM4ONW5 MA Substrate DM4ONW5 RN Prediction of Transporter-Mediated Drug-Drug Interactions for Baricitinib. Clin Transl Sci. 2017 Nov;10(6):509-519. DM4ONW5 RU http://www.ncbi.nlm.nih.gov/pubmed/28749581 DM4ONW5 DI DM4ONW5 DM4ONW5 DN Baricitinib DM4ONW5 MI TTJSQEF DM4ONW5 MN Tyrosine-protein kinase (PTK) DM4ONW5 MT DTT DM4ONW5 MA Inhibitor DM4ONW5 RN 2018 FDA drug approvals.Nat Rev Drug Discov. 2019 Feb;18(2):85-89. DM4ONW5 RU https://pubmed.ncbi.nlm.nih.gov/30710142 DMWNRZT DI DMWNRZT DMWNRZT DN Basiliximab DMWNRZT MI TT10Y9E DMWNRZT MN Interleukin 2 receptor alpha (IL2RA) DMWNRZT MT DTT DMWNRZT MA Modulator DMWNRZT RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. DMWNRZT RU https://www.fda.gov/ DMU9C8F DI DMU9C8F DMU9C8F DN Bavencio DMU9C8F MI TT8ZLTI DMU9C8F MN Programmed cell death 1 ligand 1 (PD-L1) DMU9C8F MT DTT DMU9C8F MA Inhibitor DMU9C8F RN ClinicalTrials.gov (NCT03403777) Avelumab in Refractory Testicular Germ Cell Cancer.. U.S. National Institutes of Health. DMU9C8F RU https://clinicaltrials.gov/ct2/show/NCT03403777 DMLOS5R DI DMLOS5R DMLOS5R DN Bay 80-6946 DMLOS5R MI DE6OQ3W DMLOS5R MN Cytochrome P450 1A1 (CYP1A1) DMLOS5R MT DME DMLOS5R MA Metabolism DMLOS5R RN FDA label of Copanlisib. The 2020 official website of the U.S. Food and Drug Administration. DMLOS5R RU https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/209936s000lbl.pdf DMLOS5R DI DMLOS5R DMLOS5R DN Bay 80-6946 DMLOS5R MI DE4LYSA DMLOS5R MN Cytochrome P450 3A4 (CYP3A4) DMLOS5R MT DME DMLOS5R MA Metabolism DMLOS5R RN FDA label of Copanlisib. The 2020 official website of the U.S. Food and Drug Administration. DMLOS5R RU https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/209936s000lbl.pdf DMLOS5R DI DMLOS5R DMLOS5R DN Bay 80-6946 DMLOS5R MI TTEUNMR DMLOS5R MN PI3-kinase alpha (PIK3CA) DMLOS5R MT DTT DMLOS5R MA Inhibitor DMLOS5R RN 2017 FDA drug approvals.Nat Rev Drug Discov. 2018 Feb;17(2):81-85. 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DMLOS5R RU https://www.ncbi.nlm.nih.gov/pubmed/24170767 DMY85QW DI DMY85QW DMY85QW DN Bazedoxifene DMY85QW MI DEWTCUK DMY85QW MN Beta-glucuronidase (uidA) DMY85QW MT DME DMY85QW MA Metabolism DMY85QW RN Long-term administration of conjugated estrogen and bazedoxifene decreased murine fecal beta-glucuronidase activity without impacting overall microbiome community. Sci Rep. 2018 May 25;8(1):8166. DMY85QW RU https://pubmed.ncbi.nlm.nih.gov/29802368 DMY85QW DI DMY85QW DMY85QW DN Bazedoxifene DMY85QW MI TTZAYWL DMY85QW MN Estrogen receptor (ESR) DMY85QW MT DTT DMY85QW MA Modulator DMY85QW RN Bazedoxifene, a selective estrogen receptor modulator: effects on the endometrium, ovaries, and breast from a randomized controlled trial in osteoporotic postmenopausal women. Menopause. 2009 Nov-Dec;16(6):1109-15. 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DM1R5X4 RU https://www.fda.gov/ DMZPHIK DI DMZPHIK DMZPHIK DN Beclomethasone DMZPHIK MI DEDH7FP DMZPHIK MN Corticosteroid 11-beta-dehydrogenase 2 (HSD11B2) DMZPHIK MT DME DMZPHIK MA Metabolism DMZPHIK RN Metabolism of synthetic steroids by the human placenta. Placenta. 2007 Jan;28(1):39-46. DMZPHIK RU https://www.ncbi.nlm.nih.gov/pubmed/?term=16549198 DMZPHIK DI DMZPHIK DMZPHIK DN Beclomethasone DMZPHIK MI DE4LYSA DMZPHIK MN Cytochrome P450 3A4 (CYP3A4) DMZPHIK MT DME DMZPHIK MA Metabolism DMZPHIK RN Metabolism of beclomethasone dipropionate by cytochrome P450 3A enzymes. J Pharmacol Exp Ther. 2013 May;345(2):308-16. DMZPHIK RU https://www.ncbi.nlm.nih.gov/pubmed/?term=23512537 DMZPHIK DI DMZPHIK DMZPHIK DN Beclomethasone DMZPHIK MI DTUGYRD DMZPHIK MN P-glycoprotein 1 (ABCB1) DMZPHIK MT DTP DMZPHIK MA Substrate DMZPHIK RN Oral and inhaled corticosteroids: differences in P-glycoprotein (ABCB1) mediated efflux. Toxicol Appl Pharmacol. 2012 May 1;260(3):294-302. DMZPHIK RU https://doi.org/10.1016/j.taap.2012.03.008 DMZPHIK DI DMZPHIK DMZPHIK DN Beclomethasone DMZPHIK MI TTP3UTW DMZPHIK MN Steroid hormone receptor ERR (ESRR) DMZPHIK MT DTT DMZPHIK MA Modulator DMZPHIK RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. DMZPHIK RU https://www.fda.gov/ DM3906J DI DM3906J DM3906J DN Bedaquiline DM3906J MI DE4LYSA DM3906J MN Cytochrome P450 3A4 (CYP3A4) DM3906J MT DME DM3906J MA Metabolism DM3906J RN Bedaquiline metabolism: enzymes and novel metabolites. Drug Metab Dispos. 2014 May;42(5):863-6. DM3906J RU https://www.ncbi.nlm.nih.gov/pubmed/?term=24513655 DM3906J DI DM3906J DM3906J DN Bedaquiline DM3906J MI TT19K0L DM3906J MN Mycobacterium Proton pump (MycB Prop) DM3906J MT DTT DM3906J MA Modulator DM3906J RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015 DM3906J RU https://www.accessdata.fda.gov/scripts/cder/drugsatfda/ DM8WCXM DI DM8WCXM DM8WCXM DN Befunolol hci DM8WCXM MI TTVIREA DM8WCXM MN Adrenergic receptor (ADR) DM8WCXM MT DTT DM8WCXM MA Modulator DM8WCXM RN Natural products as sources of new drugs over the last 25 years. J Nat Prod. 2007 Mar;70(3):461-77. DM8WCXM RU https://pubmed.ncbi.nlm.nih.gov/17309302 DMBT3AI DI DMBT3AI DMBT3AI DN Belantamab mafodotin DMBT3AI MI TTZ3P4W DMBT3AI MN B-cell maturation protein (TNFRSF17) DMBT3AI MT DTT DMBT3AI RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health Human Services. 2020 DMBT3AI RU https://www.accessdata.fda.gov/drugsatfda_docs/label/2020/761158s000lbl.pdf DMXLYQF DI DMXLYQF DMXLYQF DN Belatacept DMXLYQF MI TTQ13FT DMXLYQF MN T-cell-specific surface glycoprotein CD28 (CD28) DMXLYQF MT DTT DMXLYQF MA Inhibitor DMXLYQF RN New developments in immunosuppressive therapy for heart transplantation. Expert Opin Emerg Drugs. 2009 Mar;14(1):1-21. DMXLYQF RU https://pubmed.ncbi.nlm.nih.gov/19265486 DM3OBQF DI DM3OBQF DM3OBQF DN Belimumab DM3OBQF MI TTWMIDN DM3OBQF MN B-cell-activating factor (TNFSF13B) DM3OBQF MT DTT DM3OBQF RN Clinical pipeline report, company report or official report of GlaxoSmithKline (2009). DM3OBQF RU http://www.gsk.com/investors/product_pipeline/docs/gsk-pipeline-feb09.pdf DM2RBWK DI DM2RBWK DM2RBWK DN Belladonna DM2RBWK MI TTH18TF DM2RBWK MN Muscarinic acetylcholine receptor M5 (CHRM5) DM2RBWK MT DTT DM2RBWK MA Modulator DM2RBWK RN Plasma level of atropine after accidental ingestion of Atropa belladonna. Clin Toxicol (Phila). 2009 Jul;47(6):602-4. DM2RBWK RU https://pubmed.ncbi.nlm.nih.gov/19586361 DM3SRJZ DI DM3SRJZ DM3SRJZ DN Belotecan hydrocholoride DM3SRJZ MI TTGTQHC DM3SRJZ MN DNA topoisomerase I (TOP1) DM3SRJZ MT DTT DM3SRJZ MA Modulator DM3SRJZ RN Impact of natural products on developing new anti-cancer agents. Chem Rev. 2009 Jul;109(7):3012-43. DM3SRJZ RU https://pubmed.ncbi.nlm.nih.gov/19422222 DM1CI9R DI DM1CI9R DM1CI9R DN Bempedoic acid DM1CI9R MI TT0Z6Y2 DM1CI9R MN ATP-citrate synthase (ACLY) DM1CI9R MT DTT DM1CI9R MA Inhibitor DM1CI9R RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health Human Services. 2020 DM1CI9R RU https://www.accessdata.fda.gov/drugsatfda_docs/label/2020/211616s000lbl.pdf DM1CI9R DI DM1CI9R DM1CI9R DN Bempedoic acid DM1CI9R MI TTRA79S DM1CI9R MN Cholesterol synthesis (Chole synth) DM1CI9R MT DTT DM1CI9R MA Inhibitor DM1CI9R RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health Human Services. 2020 DM1CI9R RU https://www.accessdata.fda.gov/drugsatfda_docs/label/2020/211616s000lbl.pdf DMH1M9B DI DMH1M9B DMH1M9B DN Benazepril DMH1M9B MI TTL69WB DMH1M9B MN Angiotensin-converting enzyme (ACE) DMH1M9B MT DTT DMH1M9B MA Inhibitor DMH1M9B RN Efficacy of benazepril hydrochloride to delay the progression of occult dilated cardiomyopathy in Doberman Pinschers. 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DMH1M9B RU http://www.ncbi.nlm.nih.gov/pubmed/18713951 DMH1M9B DI DMH1M9B DMH1M9B DN Benazepril DMH1M9B MI DT8QKNP DMH1M9B MN Peptide transporter 2 (SLC15A2) DMH1M9B MT DTP DMH1M9B MA Substrate DMH1M9B RN Transport of angiotensin-converting enzyme inhibitors by H+/peptide transporters revisited. J Pharmacol Exp Ther. 2008 Nov;327(2):432-41. DMH1M9B RU http://www.ncbi.nlm.nih.gov/pubmed/18713951 DMFH15Z DI DMFH15Z DMFH15Z DN Bendamustine hydrochloride DMFH15Z MI DEJGDUW DMFH15Z MN Cytochrome P450 1A2 (CYP1A2) DMFH15Z MT DME DMFH15Z MA Metabolism DMFH15Z RN Pharmacokinetic and pharmacodynamic profile of bendamustine and its metabolites. Cancer Chemother Pharmacol. 2015 Jun;75(6):1143-54. DMFH15Z RU https://www.ncbi.nlm.nih.gov/pubmed/?term=25829094 DMFH15Z DI DMFH15Z DMFH15Z DN Bendamustine hydrochloride DMFH15Z MI TTUTN1I DMFH15Z MN Human Deoxyribonucleic acid (hDNA) DMFH15Z MT DTT DMFH15Z MA Modulator DMFH15Z RN 2008 FDA drug approvals. Nat Rev Drug Discov. 2009 Feb;8(2):93-6. DMFH15Z RU https://pubmed.ncbi.nlm.nih.gov/19180096 DM7EVLC DI DM7EVLC DM7EVLC DN Bendroflumethiazide DM7EVLC MI TTS087L DM7EVLC MN Solute carrier family 12 member 1 (SLC12A1) DM7EVLC MT DTT DM7EVLC MA Blocker DM7EVLC RN DrugBank: a knowledgebase for drugs, drug actions and drug targets. Nucleic Acids Res. 2008 Jan;36(Database issue):D901-6. DM7EVLC RU https://pubmed.ncbi.nlm.nih.gov/18048412 DM7EVLC DI DM7EVLC DM7EVLC DN Bendroflumethiazide DM7EVLC MI TTP362L DM7EVLC MN Solute carrier family 12 member 3 (SLC12A3) DM7EVLC MT DTT DM7EVLC MA Blocker DM7EVLC RN DrugBank: a knowledgebase for drugs, drug actions and drug targets. Nucleic Acids Res. 2008 Jan;36(Database issue):D901-6. DM7EVLC RU https://pubmed.ncbi.nlm.nih.gov/18048412 DM7P1J4 DI DM7P1J4 DM7P1J4 DN Benralizumab DM7P1J4 MI TTXH9AD DM7P1J4 MN Interleukin 5 receptor alpha (IL5RA) DM7P1J4 MT DTT DM7P1J4 MA Modulator DM7P1J4 RN Benralizumab--a humanized mAb to IL-5R with enhanced antibody-dependent cell-mediated cytotoxicity--a novel approach for the treatment of asthma. Expert Opin Biol Ther. 2012 Jan;12(1):113-8. DM7P1J4 RU https://www.ncbi.nlm.nih.gov/pubmed/22136436 DM7P1J4 DI DM7P1J4 DM7P1J4 DN Benralizumab DM7P1J4 MI TTPREZD DM7P1J4 MN Interleukin-5 (IL5) DM7P1J4 MT DTT DM7P1J4 MA Modulator DM7P1J4 RN Benralizumab a humanized mAb to IL-5R with enhanced antibody-dependent cell-mediated cytotoxicity a novel approach for the treatment of asthma DM7P1J4 RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3587289 DMRVBWU DI DMRVBWU DMRVBWU DN Bentazepam DMRVBWU MI TTEX6LM DMRVBWU MN GABA(A) receptor gamma-3 (GABRG3) DMRVBWU MT DTT DMRVBWU MA Modulator DMRVBWU RN Prodynorphin gene deletion increased anxiety-like behaviours, impaired the anxiolytic effect of bromazepam and altered GABAA receptor subunits gene expression in the amygdala. J Psychopharmacol. 2011Jan;25(1):87-96. DMRVBWU RU https://pubmed.ncbi.nlm.nih.gov/20530587 DMF7EXL DI DMF7EXL DMF7EXL DN Benzatropine DMF7EXL MI DECB0K3 DMF7EXL MN Cytochrome P450 2D6 (CYP2D6) DMF7EXL MT DME DMF7EXL MA Metabolism DMF7EXL RN Transport, metabolism, and in vivo population pharmacokinetics of the chloro benztropine analogs, a class of compounds extensively evaluated in animal models of drug abuse. J Pharmacol Exp Ther. 2007 Jan;320(1):344-53. DMF7EXL RU https://www.ncbi.nlm.nih.gov/pubmed/?term=17003230 DMF7EXL DI DMF7EXL DMF7EXL DN Benzatropine DMF7EXL MI DEGTFWK DMF7EXL MN Mephenytoin 4-hydroxylase (CYP2C19) DMF7EXL MT DME DMF7EXL MA Metabolism DMF7EXL RN Transport, metabolism, and in vivo population pharmacokinetics of the chloro benztropine analogs, a class of compounds extensively evaluated in animal models of drug abuse. J Pharmacol Exp Ther. 2007 Jan;320(1):344-53. DMF7EXL RU https://www.ncbi.nlm.nih.gov/pubmed/?term=17003230 DMC3YUA DI DMC3YUA DMC3YUA DN Benzbromarone DMC3YUA MI TTOJI4S DMC3YUA MN Calcium-dependent chloride channel anoctamin (ANO) DMC3YUA MT DTT DMC3YUA MA Antagonist DMC3YUA RN Anoctamin Channels in Human Myometrium: A Novel Target for Tocolysis.Reprod Sci. 2018 Nov;25(11):1589-1600. DMC3YUA RU https://pubmed.ncbi.nlm.nih.gov/29471754 DMC3YUA DI DMC3YUA DMC3YUA DN Benzbromarone DMC3YUA MI DE5IED8 DMC3YUA MN Cytochrome P450 2C9 (CYP2C9) DMC3YUA MT DME DMC3YUA MA Metabolism DMC3YUA RN Quantitative binding models for CYP2C9 based on benzbromarone analogues. Biochemistry. 2004 Jun 8;43(22):6948-58. 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DMIJATC RU https://www.ncbi.nlm.nih.gov/pubmed/?term=19144770 DMIJATC DI DMIJATC DMIJATC DN Benzphetamine DMIJATC MI DE4LYSA DMIJATC MN Cytochrome P450 3A4 (CYP3A4) DMIJATC MT DME DMIJATC MA Metabolism DMIJATC RN Identification of the human and animal hepatic cytochromes P450 involved in clonazepam metabolism. Fundam Clin Pharmacol. 1993;7(2):69-75. DMIJATC RU https://www.ncbi.nlm.nih.gov/pubmed/?term=8486332 DMIJATC DI DMIJATC DMIJATC DN Benzphetamine DMIJATC MI DEIZLTN DMIJATC MN Docosahexaenoic acid omega-hydroxylase (CYP4F11) DMIJATC MT DME DMIJATC MA Metabolism DMIJATC RN Expression and characterization of human cytochrome P450 4F11: putative role in the metabolism of therapeutic drugs and eicosanoids. Toxicol Appl Pharmacol. 2004 Sep 15;199(3):295-304. DMIJATC RU https://pubmed.ncbi.nlm.nih.gov/15364545 DMIJATC DI DMIJATC DMIJATC DN Benzphetamine DMIJATC MI DE3N2FM DMIJATC MN NADPH-cytochrome P450 reductase (CPR) DMIJATC MT DME DMIJATC MA Metabolism DMIJATC RN On the mechanism of the inactivation of the major phenobarbital-inducible isozyme of rat liver cytochrome P-450 by chloramphenicol. J Biol Chem. 1985 Jul 15;260(14):8397-403. DMIJATC RU https://www.ncbi.nlm.nih.gov/pubmed/?term=3924914 DMIJATC DI DMIJATC DMIJATC DN Benzphetamine DMIJATC MI TT9IK2Z DMIJATC MN N-methyl-D-aspartate receptor (NMDAR) DMIJATC MT DTT DMIJATC MA Antagonist DMIJATC RN Amphetamine inhibits the N-methyl-D-aspartate receptor-mediated responses by directly interacting with the receptor/channel complex. J Pharmacol Exp Ther. 2002 Mar;300(3):1008-16. DMIJATC RU https://pubmed.ncbi.nlm.nih.gov/11861810 DMU4D5Y DI DMU4D5Y DMU4D5Y DN Benzquinamide DMU4D5Y MI TT0JLSD DMU4D5Y MN Multidrug resistance protein (MDR) DMU4D5Y MT DTT DMU4D5Y MA Inhibitor DMU4D5Y RN Benzquinamide inhibits P-glycoprotein mediated drug efflux and potentiates anticancer agent cytotoxicity in multidrug resistant cells. Oncol Res. 1992;4(8-9):359-65. DMU4D5Y RU https://pubmed.ncbi.nlm.nih.gov/1362504 DMQWZ0H DI DMQWZ0H DMQWZ0H DN Benzthiazide DMQWZ0H MI TTANPDJ DMQWZ0H MN Carbonic anhydrase II (CA-II) DMQWZ0H MT DTT DMQWZ0H MA Inhibitor DMQWZ0H RN Nature of the inhibition of carbonic anhydrase by acetazolamide and benzthiazide. J Pharmacol Exp Ther. 1961 Mar;131:271-4. DMQWZ0H RU https://pubmed.ncbi.nlm.nih.gov/13760527 DMGZOVN DI DMGZOVN DMGZOVN DN Benztropine DMGZOVN MI TTZ9SOR DMGZOVN MN Muscarinic acetylcholine receptor M1 (CHRM1) DMGZOVN MT DTT DMGZOVN MA Antagonist DMGZOVN RN Formulation and biopharmaceutical evaluation of transdermal patch containing benztropine. Int J Pharm. 2008 Jun 5;357(1-2):55-60. DMGZOVN RU https://pubmed.ncbi.nlm.nih.gov/18417307 DMGZOVN DI DMGZOVN DMGZOVN DN Benztropine DMGZOVN MI DT3BA8L DMGZOVN MN Sodium-dependent dopamine transporter (SLC6A3) DMGZOVN MT DTP DMGZOVN MA Substrate DMGZOVN RN Pharmacological characterization of a dopamine transporter ligand that functions as a cocaine antagonist. J Pharmacol Exp Ther. 2014 Jan;348(1):106-15. DMGZOVN RU http://www.ncbi.nlm.nih.gov/pubmed/24194528 DMBVYDI DI DMBVYDI DMBVYDI DN Benzyl alcohol DMBVYDI MI DEWYTJB DMBVYDI MN Aldehyde dehydrogenase 2 (ALDH2) DMBVYDI MT DME DMBVYDI MA Metabolism DMBVYDI RN Effects of ALDH2, CYP1A1, and CYP2E1 genetic polymorphisms and smoking and drinking habits on toluene metabolism in humans. Toxicol Appl Pharmacol. 1995 Aug;133(2):295-304. DMBVYDI RU https://www.ncbi.nlm.nih.gov/pubmed/?term=7645026 DMBVYDI DI DMBVYDI DMBVYDI DN Benzyl alcohol DMBVYDI MI DEJGDUW DMBVYDI MN Cytochrome P450 1A2 (CYP1A2) DMBVYDI MT DME DMBVYDI MA Metabolism DMBVYDI RN Cytochrome P450 isozymes responsible for the metabolism of toluene and styrene in human liver microsomes. Xenobiotica. 1997 Jul;27(7):657-65. DMBVYDI RU https://www.ncbi.nlm.nih.gov/pubmed/?term=9253143 DMBVYDI DI DMBVYDI DMBVYDI DN Benzyl alcohol DMBVYDI MI DES5XRU DMBVYDI MN Cytochrome P450 2C8 (CYP2C8) DMBVYDI MT DME DMBVYDI MA Metabolism DMBVYDI RN Cytochrome P450 isozymes responsible for the metabolism of toluene and styrene in human liver microsomes. Xenobiotica. 1997 Jul;27(7):657-65. DMBVYDI RU https://www.ncbi.nlm.nih.gov/pubmed/?term=9253143 DMBVYDI DI DMBVYDI DMBVYDI DN Benzyl alcohol DMBVYDI MI DECB0K3 DMBVYDI MN Cytochrome P450 2D6 (CYP2D6) DMBVYDI MT DME DMBVYDI MA Metabolism DMBVYDI RN Mechanism of cytochrome P4503A4- and 2D6-catalyzed dehydrogenation of ezlopitant as probed with isotope effects using five deuterated analogs. Drug Metab Dispos. 2001 Dec;29(12):1599-607. DMBVYDI RU https://www.ncbi.nlm.nih.gov/pubmed/?term=11717179 DMBVYDI DI DMBVYDI DMBVYDI DN Benzyl alcohol DMBVYDI MI DEVDYN7 DMBVYDI MN Cytochrome P450 2E1 (CYP2E1) DMBVYDI MT DME DMBVYDI MA Metabolism DMBVYDI RN The metabolic rate constants and specific activity of human and rat hepatic cytochrome P-450 2E1 toward toluene and chloroform. J Toxicol Environ Health A. 2004 Apr 9;67(7):537-53. DMBVYDI RU https://www.ncbi.nlm.nih.gov/pubmed/?term=15129551 DMBVYDI DI DMBVYDI DMBVYDI DN Benzyl alcohol DMBVYDI MI DEYWLRK DMBVYDI MN Sulfotransferase 1A1 (SULT1A1) DMBVYDI MT DME DMBVYDI MA Metabolism DMBVYDI RN Sulfation of benzyl alcohol by the human cytosolic sulfotransferases (SULTs): a systematic analysis. J Appl Toxicol. 2016 Sep;36(9):1090-4. DMBVYDI RU https://www.ncbi.nlm.nih.gov/pubmed/?term=26663444 DMBVYDI DI DMBVYDI DMBVYDI DN Benzyl alcohol DMBVYDI MI DERUZL7 DMBVYDI MN Sulfotransferase 1A2 (SULT1A2) DMBVYDI MT DME DMBVYDI MA Metabolism DMBVYDI RN Sulfation of benzyl alcohol by the human cytosolic sulfotransferases (SULTs): a systematic analysis. J Appl Toxicol. 2016 Sep;36(9):1090-4. DMBVYDI RU https://www.ncbi.nlm.nih.gov/pubmed/?term=26663444 DMBVYDI DI DMBVYDI DMBVYDI DN Benzyl alcohol DMBVYDI MI DED5UR3 DMBVYDI MN Sulfotransferase 1B1 (SULT1B1) DMBVYDI MT DME DMBVYDI MA Metabolism DMBVYDI RN Sulfation of benzyl alcohol by the human cytosolic sulfotransferases (SULTs): a systematic analysis. J Appl Toxicol. 2016 Sep;36(9):1090-4. DMBVYDI RU https://www.ncbi.nlm.nih.gov/pubmed/?term=26663444 DMDPYI5 DI DMDPYI5 DMDPYI5 DN Benzyl benzoate DMDPYI5 MI TTLUQ8E DMDPYI5 MN Hormone sensitive lipase (LIPE) DMDPYI5 MT DTT DMDPYI5 MA Modulator DMDPYI5 RN The ChEMBL database in 2017. Nucleic Acids Res. 2017 Jan 4;45(D1):D945-D954. DMDPYI5 RU https://www.ncbi.nlm.nih.gov/pubmed/27899562 DMDPYI5 DI DMDPYI5 DMDPYI5 DN Benzyl benzoate DMDPYI5 MI DE4IY8S DMDPYI5 MN Peroxidase (katG) DMDPYI5 MT DME DMDPYI5 MA Metabolism DMDPYI5 RN Peroxidase activity in the sulfate-reducing bacterium Desulfotomaculum acetoxidans DSM 771. Pol J Microbiol. 2010;59(4):249-55. DMDPYI5 RU https://pubmed.ncbi.nlm.nih.gov/21466042 DMQHM2D DI DMQHM2D DMQHM2D DN Benzylpenicilloyl Polylysine DMQHM2D MI TTDGEC0 DMQHM2D MN Immunoglobulin epsilon Fc receptor gamma (FCERG) DMQHM2D MT DTT DMQHM2D MA Binder DMQHM2D RN Penicillin allergy: anti-penicillin IgE antibodies and immediate hypersensitivity skin reactions employing major and minor determinants of penicillin. Arch Dis Child. 1980 Nov;55(11):857-60. DMQHM2D RU https://pubmed.ncbi.nlm.nih.gov/7436456 DMXDZAQ DI DMXDZAQ DMXDZAQ DN Bepotastine DMXDZAQ MI TTTIBOJ DMXDZAQ MN Histamine H1 receptor (H1R) DMXDZAQ MT DTT DMXDZAQ MA Antagonist DMXDZAQ RN Mast cells play a critical role in the pathogenesis of viral myocarditis. Circulation. 2008 Jul 22;118(4):363-72. DMXDZAQ RU https://pubmed.ncbi.nlm.nih.gov/18606918 DM0RKS4 DI DM0RKS4 DM0RKS4 DN Bepridil DM0RKS4 MI TT5HONZ DM0RKS4 MN Calcium channel unspecific (CaC) DM0RKS4 MT DTT DM0RKS4 MA Modulator DM0RKS4 RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. DM0RKS4 RU https://www.fda.gov/ DM0RKS4 DI DM0RKS4 DM0RKS4 DN Bepridil DM0RKS4 MI DECB0K3 DM0RKS4 MN Cytochrome P450 2D6 (CYP2D6) DM0RKS4 MT DME DM0RKS4 MA Metabolism DM0RKS4 RN Serum flecainide S/R ratio reflects the CYP2D6 genotype and changes in CYP2D6 activity. Drug Metab Pharmacokinet. 2015 Aug;30(4):257-62. DM0RKS4 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=26195225 DM0RKS4 DI DM0RKS4 DM0RKS4 DN Bepridil DM0RKS4 MI DE4LYSA DM0RKS4 MN Cytochrome P450 3A4 (CYP3A4) DM0RKS4 MT DME DM0RKS4 MA Metabolism DM0RKS4 RN Integrated analysis on the physicochemical properties of dihydropyridine calcium channel blockers in grapefruit juice interactions. Curr Pharm Biotechnol. 2012 Jul;13(9):1705-17. DM0RKS4 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=22039822 DM0RKS4 DI DM0RKS4 DM0RKS4 DN Bepridil DM0RKS4 MI DTUGYRD DM0RKS4 MN P-glycoprotein 1 (ABCB1) DM0RKS4 MT DTP DM0RKS4 MA Substrate DM0RKS4 RN Mammalian drug efflux transporters of the ATP binding cassette (ABC) family in multidrug resistance: A review of the past decade. Cancer Lett. 2016 Jan 1;370(1):153-64. DM0RKS4 RU http://www.ncbi.nlm.nih.gov/pubmed/26499806 DMEBY2D DI DMEBY2D DMEBY2D DN Beriplast-P DMEBY2D MI TTWODQF DMEBY2D MN Fibrin (FG) DMEBY2D MT DTT DMEBY2D MA Modulator DMEBY2D RN Wound healing and degradation of the fibrin sealant Beriplast P following partial liver resection in rabbits. Wound Repair Regen. 2005 May-Jun;13(3):318-23. DMEBY2D RU https://pubmed.ncbi.nlm.nih.gov/15953052 DMWA2DZ DI DMWA2DZ DMWA2DZ DN Berotralstat DMWA2DZ MI TTMF8H9 DMWA2DZ MN Plasma kallikrein (KLKB1) DMWA2DZ MT DTT DMWA2DZ MA Inhibitor DMWA2DZ RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health Human Services. 2020 DMWA2DZ RU https://www.accessdata.fda.gov/drugsatfda_docs/label/2020/214094s000lbl.pdf DMPHXMI DI DMPHXMI DMPHXMI DN Besifloxacin DMPHXMI MI TTN6J5F DMPHXMI MN Bacterial DNA gyrase (Bact gyrase) DMPHXMI MT DTT DMPHXMI MA Modulator DMPHXMI RN Hughes B: 2009 FDA drug approvals. Nat Rev Drug Discov. 2010 Feb;9(2):89-92. DMPHXMI RU https://pubmed.ncbi.nlm.nih.gov/20118952 DMPHXMI DI DMPHXMI DMPHXMI DN Besifloxacin DMPHXMI MI TTIXTO3 DMPHXMI MN Staphylococcus Topoisomerase IV (Stap-coc parC) DMPHXMI MT DTT DMPHXMI MA Modulator DMPHXMI RN Hughes B: 2009 FDA drug approvals. Nat Rev Drug Discov. 2010 Feb;9(2):89-92. DMPHXMI RU https://pubmed.ncbi.nlm.nih.gov/20118952 DM8L9D4 DI DM8L9D4 DM8L9D4 DN Bestatin DM8L9D4 MI TTXZEAJ DM8L9D4 MN Leukotriene A-4 hydrolase (LTA4H) DM8L9D4 MT DTT DM8L9D4 MA Inhibitor DM8L9D4 RN DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Nucleic Acids Res. 2011 Jan;39(Database issue):D1035-41. DM8L9D4 RU https://pubmed.ncbi.nlm.nih.gov/21059682 DM8L9D4 DI DM8L9D4 DM8L9D4 DN Bestatin DM8L9D4 MI DT9G7XN DM8L9D4 MN Peptide transporter 1 (SLC15A1) DM8L9D4 MT DTP DM8L9D4 MA Substrate DM8L9D4 RN Dipeptide transporters in apical and basolateral membranes of the human intestinal cell line Caco-2. Am J Physiol. 1993 Aug;265(2 Pt 1):G289-94. DM8L9D4 RU http://www.ncbi.nlm.nih.gov/pubmed/8396335 DM8L9D4 DI DM8L9D4 DM8L9D4 DN Bestatin DM8L9D4 MI DT8QKNP DM8L9D4 MN Peptide transporter 2 (SLC15A2) DM8L9D4 MT DTP DM8L9D4 MA Substrate DM8L9D4 RN Molecular mechanism of dipeptide and drug transport by the human renal H+/oligopeptide cotransporter hPEPT2. Am J Physiol Renal Physiol. 2008 Jun;294(6):F1422-32. DM8L9D4 RU http://www.ncbi.nlm.nih.gov/pubmed/18367661 DMI6GKT DI DMI6GKT DMI6GKT DN Beta-acetyldigoxin DMI6GKT MI DTUGYRD DMI6GKT MN P-glycoprotein 1 (ABCB1) DMI6GKT MT DTP DMI6GKT MA Substrate DMI6GKT RN P-glycoprotein-mediated transport of digitoxin, alpha-methyldigoxin and beta-acetyldigoxin. Naunyn Schmiedebergs Arch Pharmacol. 2001 Mar;363(3):337-43. DMI6GKT RU https://doi.org/10.1007/s002100000354 DMI6GKT DI DMI6GKT DMI6GKT DN Beta-acetyldigoxin DMI6GKT MI TTYHPRQ DMI6GKT MN Sodium pump (NaP) DMI6GKT MT DTT DMI6GKT MA Modulator DMI6GKT RN Medicinal plants in therapy. Bull World Health Organ. 1985;63(6):965-81. DMI6GKT RU https://pubmed.ncbi.nlm.nih.gov/3879679 DM0RXBT DI DM0RXBT DM0RXBT DN Beta-carotene DM0RXBT MI DE6BOK3 DM0RXBT MN Beta,beta-carotene 15,15'-dioxygenase (BCO1) DM0RXBT MT DME DM0RXBT MA Metabolism DM0RXBT RN Substrate specificity of purified recombinant human beta-carotene 15,15'-oxygenase (BCO1). J Biol Chem. 2013 Dec 27;288(52):37094-103. DM0RXBT RU https://www.ncbi.nlm.nih.gov/pubmed/?term=24187135 DM0RXBT DI DM0RXBT DM0RXBT DN Beta-carotene DM0RXBT MI DTUGYRD DM0RXBT MN P-glycoprotein 1 (ABCB1) DM0RXBT MT DTP DM0RXBT MA Substrate DM0RXBT RN Carotenoids reverse multidrug resistance in cancer cells by interfering with ABC-transporters. Phytomedicine. 2012 Aug 15;19(11):977-87. DM0RXBT RU https://doi.org/10.1016/j.phymed.2012.05.010 DMGRZW2 DI DMGRZW2 DMGRZW2 DN Betaine DMGRZW2 MI DTBPTJF DMGRZW2 MN Na(+)/Cl(-) betaine/GABA transporter (SLC6A12) DMGRZW2 MT DTP DMGRZW2 MA Substrate DMGRZW2 RN Deletion of the betaine-GABA transporter (BGT1; slc6a12) gene does not affect seizure thresholds of adult mice. Epilepsy Res. 2011 Jun;95(1-2):70-81. DMGRZW2 RU http://www.ncbi.nlm.nih.gov/pubmed/21459558 DMAHJEF DI DMAHJEF DMAHJEF DN Betamethasone DMAHJEF MI TTYRL6O DMAHJEF MN Glucocorticoid receptor (NR3C1) DMAHJEF MT DTT DMAHJEF MA Agonist DMAHJEF RN The cannabinoid CB2 receptor inverse agonist JTE-907 suppresses spontaneous itch-associated responses of NC mice, a model of atopic dermatitis. Eur J Pharmacol. 2006 Aug 7;542(1-3):179-83. DMAHJEF RU https://pubmed.ncbi.nlm.nih.gov/16824511 DMAHJEF DI DMAHJEF DMAHJEF DN Betamethasone DMAHJEF MI DTUGYRD DMAHJEF MN P-glycoprotein 1 (ABCB1) DMAHJEF MT DTP DMAHJEF MA Substrate DMAHJEF RN Structural determinants of P-glycoprotein-mediated transport of glucocorticoids. Pharm Res. 2003 Nov;20(11):1794-803. DMAHJEF RU http://www.ncbi.nlm.nih.gov/pubmed/14661924 DMRMS1A DI DMRMS1A DMRMS1A DN Betamethasone Benzoate DMRMS1A MI TTYRL6O DMRMS1A MN Glucocorticoid receptor (NR3C1) DMRMS1A MT DTT DMRMS1A MA Modulator DMRMS1A RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. DMRMS1A RU https://www.fda.gov/ DMMIAXO DI DMMIAXO DMMIAXO DN Betamethasone valerate DMMIAXO MI DEDH7FP DMMIAXO MN Corticosteroid 11-beta-dehydrogenase 2 (HSD11B2) DMMIAXO MT DME DMMIAXO MA Metabolism DMMIAXO RN Metabolism of synthetic steroids by the human placenta. Placenta. 2007 Jan;28(1):39-46. DMMIAXO RU https://www.ncbi.nlm.nih.gov/pubmed/?term=16549198 DMMIAXO DI DMMIAXO DMMIAXO DN Betamethasone valerate DMMIAXO MI DE4LYSA DMMIAXO MN Cytochrome P450 3A4 (CYP3A4) DMMIAXO MT DME DMMIAXO MA Metabolism DMMIAXO RN Studies on Drug Interactions between CYP3A4 Inhibitors and Glucocorticoids. DMMIAXO RU https://pdfs.semanticscholar.org/dc99/4682bd504ab29f1c7075b9d769eb4ac4a9ce.pdf DMMIAXO DI DMMIAXO DMMIAXO DN Betamethasone valerate DMMIAXO MI TTYRL6O DMMIAXO MN Glucocorticoid receptor (NR3C1) DMMIAXO MT DTT DMMIAXO MA Modulator DMMIAXO RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. DMMIAXO RU https://www.fda.gov/ DM6EUL5 DI DM6EUL5 DM6EUL5 DN Betaxolol DM6EUL5 MI TTR6W5O DM6EUL5 MN Adrenergic receptor beta-1 (ADRB1) DM6EUL5 MT DTT DM6EUL5 MA Antagonist DM6EUL5 RN beta-adrenergic enhancement of brain kynurenic acid production mediated via cAMP-related protein kinase A signaling. Prog Neuropsychopharmacol Biol Psychiatry. 2009 Apr 30;33(3):519-29. DM6EUL5 RU https://pubmed.ncbi.nlm.nih.gov/19439240 DM6EUL5 DI DM6EUL5 DM6EUL5 DN Betaxolol DM6EUL5 MI DEJGDUW DM6EUL5 MN Cytochrome P450 1A2 (CYP1A2) DM6EUL5 MT DME DM6EUL5 MA Metabolism DM6EUL5 RN Drugs that may have potential CYP1A2 interactions. DM6EUL5 RU https://drug-interactions.medicine.iu.edu/MainTable.aspx DM6EUL5 DI DM6EUL5 DM6EUL5 DN Betaxolol DM6EUL5 MI DECB0K3 DM6EUL5 MN Cytochrome P450 2D6 (CYP2D6) DM6EUL5 MT DME DM6EUL5 MA Metabolism DM6EUL5 RN Association of CYP2D6 and ADRB1 genes with hypotensive and antichronotropic action of betaxolol in patients with arterial hypertension. Fundam Clin Pharmacol. 2007 Aug;21(4):437-43. DM6EUL5 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=17635183 DMUFGAY DI DMUFGAY DMUFGAY DN Betazole DMUFGAY MI TTQHJ1K DMUFGAY MN Histamine H2 receptor (H2R) DMUFGAY MT DTT DMUFGAY MA Antagonist DMUFGAY RN Effect of nizatidine and cimetidine on betazole-stimulated gastric secretion of normal subjects: comparison of effects on acid, water, and pepsin. Am J Gastroenterol. 1988 Jan;83(1):32-6. DMUFGAY RU https://pubmed.ncbi.nlm.nih.gov/2892392 DMCLHO0 DI DMCLHO0 DMCLHO0 DN Bethanechol DMCLHO0 MI TTH18TF DMCLHO0 MN Muscarinic acetylcholine receptor M5 (CHRM5) DMCLHO0 MT DTT DMCLHO0 MA Agonist DMCLHO0 RN Loss of Ca-mediated ion transport during colitis correlates with reduced ion transport responses to a Ca-activated K channel opener. Br J Pharmacol. 2009 Apr;156(7):1085-97. DMCLHO0 RU https://pubmed.ncbi.nlm.nih.gov/19298254 DM2C4RF DI DM2C4RF DM2C4RF DN Betrixaban DM2C4RF MI TTCIHJA DM2C4RF MN Coagulation factor Xa (F10) DM2C4RF MT DTT DM2C4RF MA Modulator DM2C4RF RN Company report (Portola) DM2C4RF RU https://www.portola.com/clinical-development/betrixaban-fxa-inhibitor/ DM2C4RF DI DM2C4RF DM2C4RF DN Betrixaban DM2C4RF MI DTUGYRD DM2C4RF MN P-glycoprotein 1 (ABCB1) DM2C4RF MT DTP DM2C4RF MA Substrate DM2C4RF RN Profile of betrixaban and its potential in the prevention and treatment of venous thromboembolism. Vasc Health Risk Manag. 2015 Jun 26;11:343-51. DM2C4RF RU http://www.ncbi.nlm.nih.gov/pubmed/26170684 DMSD1UN DI DMSD1UN DMSD1UN DN Bevacizumab DMSD1UN MI TTOHSBA DMSD1UN MN Vascular endothelial growth factor A (VEGFA) DMSD1UN MT DTT DMSD1UN MA Inhibitor DMSD1UN RN FDA Approved Drug Products from FDA Official Website. 2004. Application Number: (ANDA) 125085. DMSD1UN RU https://www.accessdata.fda.gov/scripts/cder/daf/index.cfm?event=overview.process&ApplNo=125085 DMZFICR DI DMZFICR DMZFICR DN Bevantolol DMZFICR MI DECB0K3 DMZFICR MN Cytochrome P450 2D6 (CYP2D6) DMZFICR MT DME DMZFICR MA Metabolism DMZFICR RN Application of substrate depletion assay to evaluation of CYP isoforms responsible for stereoselective metabolism of carvedilol. Drug Metab Pharmacokinet. 2016 Dec;31(6):425-432. DMZFICR RU https://www.ncbi.nlm.nih.gov/pubmed/?term=27836712 DMZFICR DI DMZFICR DMZFICR DN Bevantolol DMZFICR MI TTEX248 DMZFICR MN Dopamine D2 receptor (D2R) DMZFICR MT DTT DMZFICR MA Antagonist DMZFICR RN Determination of bevantolol in human plasma by high performance liquid chromatography using solid phase extraction technique. Arch Pharm Res. 2007 Jul;30(7):890-7. DMZFICR RU https://pubmed.ncbi.nlm.nih.gov/17703743 DMOBIKY DI DMOBIKY DMOBIKY DN Bexarotene DMOBIKY MI DE5IED8 DMOBIKY MN Cytochrome P450 2C9 (CYP2C9) DMOBIKY MT DME DMOBIKY MA Metabolism DMOBIKY RN Summary of information on human CYP enzymes: human P450 metabolism data. Drug Metab Rev. 2002 Feb-May;34(1-2):83-448. DMOBIKY RU https://www.ncbi.nlm.nih.gov/pubmed/?term=11996015 DMOBIKY DI DMOBIKY DMOBIKY DN Bexarotene DMOBIKY MI DE4LYSA DMOBIKY MN Cytochrome P450 3A4 (CYP3A4) DMOBIKY MT DME DMOBIKY MA Metabolism DMOBIKY RN Summary of information on human CYP enzymes: human P450 metabolism data. Drug Metab Rev. 2002 Feb-May;34(1-2):83-448. DMOBIKY RU https://www.ncbi.nlm.nih.gov/pubmed/?term=11996015 DMOBIKY DI DMOBIKY DMOBIKY DN Bexarotene DMOBIKY MI TT6PEUO DMOBIKY MN Retinoic acid receptor RXR-alpha (RXRA) DMOBIKY MT DTT DMOBIKY MA Modulator DMOBIKY RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. DMOBIKY RU https://www.fda.gov/ DMZDCS0 DI DMZDCS0 DMZDCS0 DN Bezafibrate DMZDCS0 MI DE4LYSA DMZDCS0 MN Cytochrome P450 3A4 (CYP3A4) DMZDCS0 MT DME DMZDCS0 MA Metabolism DMZDCS0 RN Clinical pharmacokinetics of fibric acid derivatives (fibrates). Clin Pharmacokinet. 1998 Feb;34(2):155-62. DMZDCS0 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=9515185 DMZDCS0 DI DMZDCS0 DMZDCS0 DN Bezafibrate DMZDCS0 MI TTJ584C DMZDCS0 MN Peroxisome proliferator-activated receptor alpha (PPARA) DMZDCS0 MT DTT DMZDCS0 MA Agonist DMZDCS0 RN Bezafibrate at clinically relevant doses decreases serum/liver triglycerides via down-regulation of sterol regulatory element-binding protein-1c in... Mol Pharmacol. 2009 Apr;75(4):782-92. DMZDCS0 RU https://pubmed.ncbi.nlm.nih.gov/19124612 DMTZC5G DI DMTZC5G DMTZC5G DN Bezlotoxumab DMTZC5G MI TTQH65V DMTZC5G MN Clostridium difficile Toxin B (CD toxB) DMTZC5G MT DTT DMTZC5G MA Modulator DMTZC5G RN 2016 FDA drug approvals. Nat Rev Drug Discov. 2017 Feb 2;16(2):73-76. DMTZC5G RU https://www.ncbi.nlm.nih.gov/pubmed/28148938 DMTKD7Q DI DMTKD7Q DMTKD7Q DN BIBW 2992 DMTKD7Q MI DTI7UX6 DMTKD7Q MN Breast cancer resistance protein (ABCG2) DMTKD7Q MT DTP DMTKD7Q MA Substrate DMTKD7Q RN Breast cancer resistance protein (BCRP/ABCG2) and P-glycoprotein (P-gp/ABCB1) transport afatinib and restrict its oral availability and brain accumulation. Pharmacol Res. 2017 Jun;120:43-50. DMTKD7Q RU http://www.ncbi.nlm.nih.gov/pubmed/28288939 DMTKD7Q DI DMTKD7Q DMTKD7Q DN BIBW 2992 DMTKD7Q MI TTGKNB4 DMTKD7Q MN Epidermal growth factor receptor (EGFR) DMTKD7Q MT DTT DMTKD7Q MA Inhibitor DMTKD7Q RN Boehringer Ingelheim. Product Development Pipeline. June 2 2009. DMTKD7Q RU http://www.boehringer-ingelheim.com/corporate/research/pipeline.asp DMTKD7Q DI DMTKD7Q DMTKD7Q DN BIBW 2992 DMTKD7Q MI TT6EO5L DMTKD7Q MN Erbb2 tyrosine kinase receptor (HER2) DMTKD7Q MT DTT DMTKD7Q MA Inhibitor DMTKD7Q RN Boehringer Ingelheim. Product Development Pipeline. June 2 2009. DMTKD7Q RU http://www.boehringer-ingelheim.com/corporate/research/pipeline.asp DMTKD7Q DI DMTKD7Q DMTKD7Q DN BIBW 2992 DMTKD7Q MI DTUGYRD DMTKD7Q MN P-glycoprotein 1 (ABCB1) DMTKD7Q MT DTP DMTKD7Q MA Substrate DMTKD7Q RN Breast cancer resistance protein (BCRP/ABCG2) and P-glycoprotein (P-gp/ABCB1) transport afatinib and restrict its oral availability and brain accumulation. Pharmacol Res. 2017 Jun;120:43-50. DMTKD7Q RU http://www.ncbi.nlm.nih.gov/pubmed/28288939 DMZMSPF DI DMZMSPF DMZMSPF DN Bicalutamide DMZMSPF MI TTS64P2 DMZMSPF MN Androgen receptor (AR) DMZMSPF MT DTT DMZMSPF MA Antagonist DMZMSPF RN Androgen receptor overexpression induces tamoxifen resistance in human breast cancer cells. Breast Cancer Res Treat. 2010 May;121(1):1-11. DMZMSPF RU https://pubmed.ncbi.nlm.nih.gov/19533338 DMZMSPF DI DMZMSPF DMZMSPF DN Bicalutamide DMZMSPF MI DTI7UX6 DMZMSPF MN Breast cancer resistance protein (ABCG2) DMZMSPF MT DTP DMZMSPF MA Substrate DMZMSPF RN Effects of the ABCG2 and ABCB1 drug transporter polymorphisms on the pharmacokinetics of bicalutamide in humans. Clin Chim Acta. 2015 Jan 1;438:7-11. DMZMSPF RU http://www.ncbi.nlm.nih.gov/pubmed/25124867 DMZMSPF DI DMZMSPF DMZMSPF DN Bicalutamide DMZMSPF MI DE4LYSA DMZMSPF MN Cytochrome P450 3A4 (CYP3A4) DMZMSPF MT DME DMZMSPF MA Metabolism DMZMSPF RN Bicalutamide: clinical pharmacokinetics and metabolism. Clin Pharmacokinet. 2004;43(13):855-78. DMZMSPF RU https://www.ncbi.nlm.nih.gov/pubmed/?term=15509184 DMZMSPF DI DMZMSPF DMZMSPF DN Bicalutamide DMZMSPF MI DTUGYRD DMZMSPF MN P-glycoprotein 1 (ABCB1) DMZMSPF MT DTP DMZMSPF MA Substrate DMZMSPF RN Effects of the ABCG2 and ABCB1 drug transporter polymorphisms on the pharmacokinetics of bicalutamide in humans. Clin Chim Acta. 2015 Jan 1;438:7-11. DMZMSPF RU http://www.ncbi.nlm.nih.gov/pubmed/25124867 DMG0H8K DI DMG0H8K DMG0H8K DN Bictegravir, emtricitabine and tenofovir alafenamide DMG0H8K MI TT5FH9Y DMG0H8K MN Human immunodeficiency virus Integrase (HIV IN) DMG0H8K MT DTT DMG0H8K MA Inhibitor DMG0H8K RN 2018 FDA drug approvals.Nat Rev Drug Discov. 2019 Feb;18(2):85-89. DMG0H8K RU https://pubmed.ncbi.nlm.nih.gov/30710142 DMG0H8K DI DMG0H8K DMG0H8K DN Bictegravir, emtricitabine and tenofovir alafenamide DMG0H8K MI TT84ETX DMG0H8K MN Human immunodeficiency virus Reverse transcriptase (HIV RT) DMG0H8K MT DTT DMG0H8K MA Inhibitor DMG0H8K RN 2018 FDA drug approvals.Nat Rev Drug Discov. 2019 Feb;18(2):85-89. DMG0H8K RU https://pubmed.ncbi.nlm.nih.gov/30710142 DM3KN7V DI DM3KN7V DM3KN7V DN Bifonazole DM3KN7V MI TTTSOUD DM3KN7V MN Candida Cytochrome P450 51 (Candi ERG11) DM3KN7V MT DTT DM3KN7V MA Inhibitor DM3KN7V RN Investigation of the role of cytochrome P450 2B4 active site residues in substrate metabolism based on crystal structures of the ligand-bound enzyme. Arch Biochem Biophys. 2006 Nov 1;455(1):61-7. DM3KN7V RU https://pubmed.ncbi.nlm.nih.gov/17027909 DMX0E5B DI DMX0E5B DMX0E5B DN Bimatoprost DMX0E5B MI DE4LYSA DMX0E5B MN Cytochrome P450 3A4 (CYP3A4) DMX0E5B MT DME DMX0E5B MA Metabolism DMX0E5B RN Product monograph: LUMIGAN RC (Bimatoprost). DMX0E5B RU https://allergan-web-cdn-prod.azureedge.net/allergancanadaspecialty/allergancanadaspecialty/media/actavis-canada-specialty/en/products/pms/lumigan-rc-pm-2016-05-11_e.pdf DMX0E5B DI DMX0E5B DMX0E5B DN Bimatoprost DMX0E5B MI DEIBDNY DMX0E5B MN Cytochrome P450 3A5 (CYP3A5) DMX0E5B MT DME DMX0E5B MA Metabolism DMX0E5B RN Product monograph: LUMIGAN RC (Bimatoprost). DMX0E5B RU https://allergan-web-cdn-prod.azureedge.net/allergancanadaspecialty/allergancanadaspecialty/media/actavis-canada-specialty/en/products/pms/lumigan-rc-pm-2016-05-11_e.pdf DMX0E5B DI DMX0E5B DMX0E5B DN Bimatoprost DMX0E5B MI TT9B4N3 DMX0E5B MN Prostaglandin receptor (PTGR) DMX0E5B MT DTT DMX0E5B MA Modulator DMX0E5B RN Bimatoprost-induced calcium signaling in human T-cells does not involve prostanoid FP or TP receptors. Curr Eye Res. 2009 Mar;34(3):184-95. DMX0E5B RU https://pubmed.ncbi.nlm.nih.gov/19274525 DME78OA DI DME78OA DME78OA DN Biperiden DME78OA MI TTZ9SOR DME78OA MN Muscarinic acetylcholine receptor M1 (CHRM1) DME78OA MT DTT DME78OA MA Antagonist DME78OA RN Evaluation of in vivo binding properties of 3H-NMPB and 3H-QNB in mouse brain. J Neural Transm. 1999;106(7-8):583-92. DME78OA RU https://pubmed.ncbi.nlm.nih.gov/10907719 DMTKU46 DI DMTKU46 DMTKU46 DN Bismuth DMTKU46 MI TTFNGC9 DMTKU46 MN Serum albumin (ALB) DMTKU46 MT DTT DMTKU46 MA Binder DMTKU46 RN Competitive binding of bismuth to transferrin and albumin in aqueous solution and in blood plasma. J Biol Chem. 2001 Mar 23;276(12):8829-35. DMTKU46 RU https://pubmed.ncbi.nlm.nih.gov/11110794 DM3UZ95 DI DM3UZ95 DM3UZ95 DN Bisoprolol DM3UZ95 MI TTR6W5O DM3UZ95 MN Adrenergic receptor beta-1 (ADRB1) DM3UZ95 MT DTT DM3UZ95 MA Antagonist DM3UZ95 RN Antiarrhythmic effect of bisoprolol, a highly selective beta1-blocker, in patients with paroxysmal atrial fibrillation. Int Heart J. 2008 May;49(3):281-93. DM3UZ95 RU https://pubmed.ncbi.nlm.nih.gov/18612186 DM3UZ95 DI DM3UZ95 DM3UZ95 DN Bisoprolol DM3UZ95 MI DECB0K3 DM3UZ95 MN Cytochrome P450 2D6 (CYP2D6) DM3UZ95 MT DME DM3UZ95 MA Metabolism DM3UZ95 RN Drug-drug interactions of beta-adrenoceptor blockers. Arzneimittelforschung. 2003;53(12):814-22. DM3UZ95 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=14732961 DM3UZ95 DI DM3UZ95 DM3UZ95 DN Bisoprolol DM3UZ95 MI DE4LYSA DM3UZ95 MN Cytochrome P450 3A4 (CYP3A4) DM3UZ95 MT DME DM3UZ95 MA Metabolism DM3UZ95 RN Stereoselective metabolism of bisoprolol enantiomers in dogs and humans. Life Sci. 1998;63(13):1097-108. DM3UZ95 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=9763205 DMK6XAV DI DMK6XAV DMK6XAV DN Bitolterol DMK6XAV MI TTMXGCW DMK6XAV MN Adrenergic receptor beta-3 (ADRB3) DMK6XAV MT DTT DMK6XAV MA Modulator DMK6XAV RN Bitolterol mesylate: a beta-adrenergic agent. Chemistry, pharmacokinetics, pharmacodynamics, adverse effects and clinical efficacy in asthma. Pharmacotherapy. 1985 May-Jun;5(3):127-37. DMK6XAV RU https://pubmed.ncbi.nlm.nih.gov/3895171 DMECRX1 DI DMECRX1 DMECRX1 DN Bivalirudin DMECRX1 MI TT6L509 DMECRX1 MN Coagulation factor IIa (F2) DMECRX1 MT DTT DMECRX1 MA Inhibitor DMECRX1 RN New anticoagulants. Am Heart J. 2001 Aug;142(2 Suppl):S3-8. DMECRX1 RU https://pubmed.ncbi.nlm.nih.gov/11479484 DMECRX1 DI DMECRX1 DMECRX1 DN Bivalirudin DMECRX1 MI TTRTKPV DMECRX1 MN Trypanosoma Trypanothione reductase (Trypano TPR) DMECRX1 MT DTT DMECRX1 MA Inhibitor DMECRX1 RN 8-Methoxy-naphtho[2,3-b]thiophen-4,9-quinone, a non-competitive inhibitor of trypanothione reductase. Mem Inst Oswaldo Cruz. 2003 Jun;98(4):565-8. DMECRX1 RU https://pubmed.ncbi.nlm.nih.gov/12937775 DMR8YD6 DI DMR8YD6 DMR8YD6 DN B-Lactams DMR8YD6 MI TTPOI4B DMR8YD6 MN Acetyl-CoA:lyso-PAF acetyltransferase (PCAT) DMR8YD6 MT DTT DMR8YD6 MA Inhibitor DMR8YD6 RN Inhibition of lysoPAF acetyltransferase activity by flavonoids. Inflamm Res. 1996 Nov;45(11):546-9. DMR8YD6 RU https://pubmed.ncbi.nlm.nih.gov/8951505 DMR8YD6 DI DMR8YD6 DMR8YD6 DN B-Lactams DMR8YD6 MI TTLP6GN DMR8YD6 MN Bacterial DD-carboxypeptidase (Bact vanYB) DMR8YD6 MT DTT DMR8YD6 MA Inhibitor DMR8YD6 RN Has nature already identified all useful antibacterial targets Curr Opin Microbiol. 2008 Oct;11(5):387-92. DMR8YD6 RU https://pubmed.ncbi.nlm.nih.gov/18804175 DMR8YD6 DI DMR8YD6 DMR8YD6 DN B-Lactams DMR8YD6 MI TTGTQHC DMR8YD6 MN DNA topoisomerase I (TOP1) DMR8YD6 MT DTT DMR8YD6 MA Inhibitor DMR8YD6 RN Luteolin, an emerging anti-cancer flavonoid, poisons eukaryotic DNA topoisomerase I. Biochem J. 2002 Sep 1;366(Pt 2):653-61. DMR8YD6 RU https://pubmed.ncbi.nlm.nih.gov/12027807 DMNER5S DI DMNER5S DMNER5S DN Bleomycin DMNER5S MI DECH1VP DMNER5S MN Bleomycin hydrolase (BLMH) DMNER5S MT DME DMNER5S MA Metabolism DMNER5S RN The C-terminus of human bleomycin hydrolase is required for protection against bleomycin-induced chromosomal damage. Mutat Res. 1998 Oct 12;421(1):1-7. DMNER5S RU https://www.ncbi.nlm.nih.gov/pubmed/?term=9748474 DMNER5S DI DMNER5S DMNER5S DN Bleomycin DMNER5S MI TTUTN1I DMNER5S MN Human Deoxyribonucleic acid (hDNA) DMNER5S MT DTT DMNER5S MA Breaker DMNER5S RN Bleomycin and talisomycin sequence-specific strand scission of DNA: a mechanism of double-strand cleavage. Cancer Res. 1982 Jul;42(7):2779-85. DMNER5S RU https://pubmed.ncbi.nlm.nih.gov/6177398 DMGECIJ DI DMGECIJ DMGECIJ DN Blinatumomab DMGECIJ MI TTW640A DMGECIJ MN B-lymphocyte surface antigen B4 (CD19) DMGECIJ MT DTT DMGECIJ MA Modulator DMGECIJ RN 2014 FDA drug approvals. Nat Rev Drug Discov. 2015 Feb;14(2):77-81. DMGECIJ RU https://pubmed.ncbi.nlm.nih.gov/25633781 DMGECIJ DI DMGECIJ DMGECIJ DN Blinatumomab DMGECIJ MI TTUN7MC DMGECIJ MN T-cell surface glycoprotein CD3 (CD3) DMGECIJ MT DTT DMGECIJ MA Modulator DMGECIJ RN 2014 FDA drug approvals. Nat Rev Drug Discov. 2015 Feb;14(2):77-81. DMGECIJ RU https://pubmed.ncbi.nlm.nih.gov/25633781 DMQTAGO DI DMQTAGO DMQTAGO DN BMS-201038 DMQTAGO MI TTUS1RD DMQTAGO MN Microsomal triglyceride transfer protein (MTTP) DMQTAGO MT DTT DMQTAGO MA Inhibitor DMQTAGO RN Dyslipidemia and cardiovascular diseases. Curr Opin Lipidol. 2009 Apr;20(2):157-8. DMQTAGO RU https://pubmed.ncbi.nlm.nih.gov/19276898 DMBSHMF DI DMBSHMF DMBSHMF DN Boceprevir DMBSHMF MI DE4LYSA DMBSHMF MN Cytochrome P450 3A4 (CYP3A4) DMBSHMF MT DME DMBSHMF MA Metabolism DMBSHMF RN Pharmacokinetic evaluation of the interaction between hepatitis C virus protease inhibitor boceprevir and 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors atorvastatin and pravastatin. Antimicrob Agents Chemother. 2013 Jun;57(6):2582-8. DMBSHMF RU https://www.ncbi.nlm.nih.gov/pubmed/?term=23529734 DMBSHMF DI DMBSHMF DMBSHMF DN Boceprevir DMBSHMF MI DEIBDNY DMBSHMF MN Cytochrome P450 3A5 (CYP3A5) DMBSHMF MT DME DMBSHMF MA Metabolism DMBSHMF RN Direct-acting antiviral agents for hepatitis C virus infection. Annu Rev Pharmacol Toxicol. 2013;53:427-49. DMBSHMF RU https://www.ncbi.nlm.nih.gov/pubmed/?term=23140245 DMBSHMF DI DMBSHMF DMBSHMF DN Boceprevir DMBSHMF MI TTHC7JD DMBSHMF MN Hepatitis C virus Serine protease NS3/4A (HCV NS3/4A) DMBSHMF MT DTT DMBSHMF MA Modulator DMBSHMF RN 2011 FDA drug approvals. Nat Rev Drug Discov. 2012 Feb 1;11(2):91-4. DMBSHMF RU https://pubmed.ncbi.nlm.nih.gov/22293555 DMBSHMF DI DMBSHMF DMBSHMF DN Boceprevir DMBSHMF MI DTUGYRD DMBSHMF MN P-glycoprotein 1 (ABCB1) DMBSHMF MT DTP DMBSHMF MA Substrate DMBSHMF RN Drug interactions and protease inhibitors used in the treatment of hepatitis C: how to manage? Eur J Clin Pharmacol. 2014 Jul;70(7):775-89. DMBSHMF RU http://www.ncbi.nlm.nih.gov/pubmed/24817413 DM2EXC5 DI DM2EXC5 DM2EXC5 DN BOL-303259-X DM2EXC5 MI DTPFTEQ DM2EXC5 MN Organic anion transporting polypeptide 2B1 (SLCO2B1) DM2EXC5 MT DTP DM2EXC5 MA Substrate DM2EXC5 RN The prostaglandin transporter OATP2A1 is expressed in human ocular tissues and transports the antiglaucoma prostanoid latanoprost. Invest Ophthalmol Vis Sci. 2010 May;51(5):2504-11. DM2EXC5 RU http://www.ncbi.nlm.nih.gov/pubmed/20019365 DM2EXC5 DI DM2EXC5 DM2EXC5 DN BOL-303259-X DM2EXC5 MI TTT2ZAR DM2EXC5 MN Prostaglandin F2-alpha receptor (PTGFR) DM2EXC5 MT DTT DM2EXC5 MA Agonist DM2EXC5 RN Ocular hypotensive activity of BOL-303259-X, a nitric oxide donating prostaglandin F2alpha agonist, in preclinical models. Exp Eye Res. 2011 Sep;93(3):250-5. DM2EXC5 RU https://pubmed.ncbi.nlm.nih.gov/21396362 DMIFYLX DI DMIFYLX DMIFYLX DN Bopindolol DMIFYLX MI TTMXGCW DMIFYLX MN Adrenergic receptor beta-3 (ADRB3) DMIFYLX MT DTT DMIFYLX MA Modulator DMIFYLX RN Effect of propranolol, alprenolol, pindolol, and bopindolol on beta 2-adrenoceptor density in human lymphocytes. J Cardiovasc Pharmacol. 1986;8 Suppl 6:S70-3. DMIFYLX RU https://pubmed.ncbi.nlm.nih.gov/2439825 DMIFYLX DI DMIFYLX DMIFYLX DN Bopindolol DMIFYLX MI DECB0K3 DMIFYLX MN Cytochrome P450 2D6 (CYP2D6) DMIFYLX MT DME DMIFYLX MA Metabolism DMIFYLX RN Application of substrate depletion assay to evaluation of CYP isoforms responsible for stereoselective metabolism of carvedilol. Drug Metab Pharmacokinet. 2016 Dec;31(6):425-432. DMIFYLX RU https://www.ncbi.nlm.nih.gov/pubmed/?term=27836712 DMNO38U DI DMNO38U DMNO38U DN Bortezomib DMNO38U MI TT2WR1T DMNO38U MN Cationic trypsinogen (PRSS1) DMNO38U MT DTT DMNO38U MA Inhibitor DMNO38U RN Characterization of a class of peptide boronates with neutral P1 side chains as highly selective inhibitors of thrombin. J Med Chem. 1995 Apr 28;38(9):1511-22. DMNO38U RU https://pubmed.ncbi.nlm.nih.gov/7739010 DMNO38U DI DMNO38U DMNO38U DN Bortezomib DMNO38U MI DEJGDUW DMNO38U MN Cytochrome P450 1A2 (CYP1A2) DMNO38U MT DME DMNO38U MA Metabolism DMNO38U RN Human metabolism of the proteasome inhibitor bortezomib: identification of circulating metabolites. Drug Metab Dispos. 2005 Jun;33(6):771-7. DMNO38U RU https://www.ncbi.nlm.nih.gov/pubmed/?term=15764713 DMNO38U DI DMNO38U DMNO38U DN Bortezomib DMNO38U MI DE5IED8 DMNO38U MN Cytochrome P450 2C9 (CYP2C9) DMNO38U MT DME DMNO38U MA Metabolism DMNO38U RN Investigation of drug-drug interaction potential of bortezomib in vivo in female Sprague-Dawley rats and in vitro in human liver microsomes. Drug Metab Dispos. 2006 Apr;34(4):702-8. DMNO38U RU https://www.ncbi.nlm.nih.gov/pubmed/?term=16443666 DMNO38U DI DMNO38U DMNO38U DN Bortezomib DMNO38U MI DECB0K3 DMNO38U MN Cytochrome P450 2D6 (CYP2D6) DMNO38U MT DME DMNO38U MA Metabolism DMNO38U RN Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. DMNO38U RU https://www.ncbi.nlm.nih.gov/pubmed/?term=19515014 DMNO38U DI DMNO38U DMNO38U DN Bortezomib DMNO38U MI DE4LYSA DMNO38U MN Cytochrome P450 3A4 (CYP3A4) DMNO38U MT DME DMNO38U MA Metabolism DMNO38U RN Relative contributions of the five major human cytochromes P450, 1A2, 2C9, 2C19, 2D6, and 3A4, to the hepatic metabolism of the proteasome inhibitor bortezomib. Drug Metab Dispos. 2005 Nov;33(11):1723-8. DMNO38U RU https://www.ncbi.nlm.nih.gov/pubmed/?term=16103134 DMNO38U DI DMNO38U DMNO38U DN Bortezomib DMNO38U MI TT5L2VC DMNO38U MN Kallikrein-related peptidase (KLK) DMNO38U MT DTT DMNO38U MA Inhibitor DMNO38U RN Characterization of a class of peptide boronates with neutral P1 side chains as highly selective inhibitors of thrombin. J Med Chem. 1995 Apr 28;38(9):1511-22. DMNO38U RU https://pubmed.ncbi.nlm.nih.gov/7739010 DMNO38U DI DMNO38U DMNO38U DN Bortezomib DMNO38U MI DEGTFWK DMNO38U MN Mephenytoin 4-hydroxylase (CYP2C19) DMNO38U MT DME DMNO38U MA Metabolism DMNO38U RN Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. DMNO38U RU https://www.ncbi.nlm.nih.gov/pubmed/?term=19515014 DMNO38U DI DMNO38U DMNO38U DN Bortezomib DMNO38U MI DTUGYRD DMNO38U MN P-glycoprotein 1 (ABCB1) DMNO38U MT DTP DMNO38U MA Substrate DMNO38U RN CNS uptake of bortezomib is enhanced by P-glycoprotein inhibition: implications for spinal muscular atrophy. Neurobiol Dis. 2016 Apr;88:118-24. DMNO38U RU http://www.ncbi.nlm.nih.gov/pubmed/26792401 DMNO38U DI DMNO38U DMNO38U DN Bortezomib DMNO38U MI TTU7ZMG DMNO38U MN Proteasome (PS) DMNO38U MT DTT DMNO38U MA Modulator DMNO38U RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. DMNO38U RU https://www.fda.gov/ DMIOGBU DI DMIOGBU DMIOGBU DN Bosentan DMIOGBU MI DE5IED8 DMIOGBU MN Cytochrome P450 2C9 (CYP2C9) DMIOGBU MT DME DMIOGBU MA Metabolism DMIOGBU RN Investigation of the mutual pharmacokinetic interactions between bosentan, a dual endothelin receptor antagonist, and simvastatin. Clin Pharmacokinet. 2003;42(3):293-301. DMIOGBU RU https://www.ncbi.nlm.nih.gov/pubmed/?term=12603176 DMIOGBU DI DMIOGBU DMIOGBU DN Bosentan DMIOGBU MI DE4LYSA DMIOGBU MN Cytochrome P450 3A4 (CYP3A4) DMIOGBU MT DME DMIOGBU MA Metabolism DMIOGBU RN Bosentan is a substrate of human OATP1B1 and OATP1B3: inhibition of hepatic uptake as the common mechanism of its interactions with cyclosporin A, rifampicin, and sildenafil. Drug Metab Dispos. 2007 Aug;35(8):1400-7. DMIOGBU RU https://www.ncbi.nlm.nih.gov/pubmed/?term=17496208 DMIOGBU DI DMIOGBU DMIOGBU DN Bosentan DMIOGBU MI TTKRD0G DMIOGBU MN Endothelin A receptor (EDNRA) DMIOGBU MT DTT DMIOGBU MA Modulator DMIOGBU RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. DMIOGBU RU https://www.fda.gov/ DMIOGBU DI DMIOGBU DMIOGBU DN Bosentan DMIOGBU MI TT3ZTGU DMIOGBU MN Endothelin B receptor (EDNRB) DMIOGBU MT DTT DMIOGBU MA Modulator DMIOGBU RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. DMIOGBU RU https://www.fda.gov/ DMIOGBU DI DMIOGBU DMIOGBU DN Bosentan DMIOGBU MI DT3D8F0 DMIOGBU MN Organic anion transporting polypeptide 1B1 (SLCO1B1) DMIOGBU MT DTP DMIOGBU MA Substrate DMIOGBU RN Bosentan is a substrate of human OATP1B1 and OATP1B3: inhibition of hepatic uptake as the common mechanism of its interactions with cyclosporin A, rifampicin, and sildenafil. Drug Metab Dispos. 2007 Aug;35(8):1400-7. DMIOGBU RU http://www.ncbi.nlm.nih.gov/pubmed/17496208 DMIOGBU DI DMIOGBU DMIOGBU DN Bosentan DMIOGBU MI DT9C1TS DMIOGBU MN Organic anion transporting polypeptide 1B3 (SLCO1B3) DMIOGBU MT DTP DMIOGBU MA Substrate DMIOGBU RN Bosentan is a substrate of human OATP1B1 and OATP1B3: inhibition of hepatic uptake as the common mechanism of its interactions with cyclosporin A, rifampicin, and sildenafil. Drug Metab Dispos. 2007 Aug;35(8):1400-7. DMIOGBU RU http://www.ncbi.nlm.nih.gov/pubmed/17496208 DMIOGBU DI DMIOGBU DMIOGBU DN Bosentan DMIOGBU MI DTPFTEQ DMIOGBU MN Organic anion transporting polypeptide 2B1 (SLCO2B1) DMIOGBU MT DTP DMIOGBU MA Substrate DMIOGBU RN Bosentan is a substrate of human OATP1B1 and OATP1B3: inhibition of hepatic uptake as the common mechanism of its interactions with cyclosporin A, rifampicin, and sildenafil. Drug Metab Dispos. 2007 Aug;35(8):1400-7. DMIOGBU RU http://www.ncbi.nlm.nih.gov/pubmed/17496208 DMTI8YE DI DMTI8YE DMTI8YE DN Bosutinib DMTI8YE MI DE4LYSA DMTI8YE MN Cytochrome P450 3A4 (CYP3A4) DMTI8YE MT DME DMTI8YE MA Metabolism DMTI8YE RN In vitro assessment of time-dependent inhibitory effects on CYP2C8 and CYP3A activity by fourteen protein kinase inhibitors. Drug Metab Dispos. 2014 Jul;42(7):1202-9. DMTI8YE RU https://www.ncbi.nlm.nih.gov/pubmed/?term=24713129 DMTI8YE DI DMTI8YE DMTI8YE DN Bosutinib DMTI8YE MI DTUGYRD DMTI8YE MN P-glycoprotein 1 (ABCB1) DMTI8YE MT DTP DMTI8YE MA Substrate DMTI8YE RN In vitro and in vivo identification of ABCB1 as an efflux transporter of bosutinib. J Hematol Oncol. 2015 Jul 7;8:81. DMTI8YE RU http://www.ncbi.nlm.nih.gov/pubmed/26149173 DMTI8YE DI DMTI8YE DMTI8YE DN Bosutinib DMTI8YE MI TT6PKBN DMTI8YE MN Proto-oncogene c-Src (SRC) DMTI8YE MT DTT DMTI8YE MA Inhibitor DMTI8YE RN A comparison of physicochemical property profiles of marketed oral drugs and orally bioavailable anti-cancer protein kinase inhibitors in clinical development. Curr Top Med Chem. 2007;7(14):1408-22. DMTI8YE RU https://pubmed.ncbi.nlm.nih.gov/17692029 DMTI8YE DI DMTI8YE DMTI8YE DN Bosutinib DMTI8YE MI TT3PJMV DMTI8YE MN Tyrosine-protein kinase ABL1 (ABL) DMTI8YE MT DTT DMTI8YE MA Inhibitor DMTI8YE RN A comparison of physicochemical property profiles of marketed oral drugs and orally bioavailable anti-cancer protein kinase inhibitors in clinical development. Curr Top Med Chem. 2007;7(14):1408-22. DMTI8YE RU https://pubmed.ncbi.nlm.nih.gov/17692029 DMW67MU DI DMW67MU DMW67MU DN Botulinum Toxin Type A DMW67MU MI TTYQWA0 DMW67MU MN Synaptosomal-associated protein 25 (SNAP25) DMW67MU MT DTT DMW67MU MA Inhibitor DMW67MU RN Evaluation of the therapeutic usefulness of botulinum neurotoxin B, C1, E, and F compared with the long lasting type A. Basis for distinct duration... J Biol Chem. 2003 Jan 10;278(2):1363-71. DMW67MU RU https://pubmed.ncbi.nlm.nih.gov/12381720 DM58QS1 DI DM58QS1 DM58QS1 DN Botulinum Toxin Type B DM58QS1 MI TTG25NJ DM58QS1 MN Vesicle-associated membrane protein (VAMP) DM58QS1 MT DTT DM58QS1 MA Binder DM58QS1 RN Long-lasting benefits of botulinum toxin type B in Parkinson's disease-related drooling. J Neurol. 2009 Apr;256(4):563-7. DM58QS1 RU https://pubmed.ncbi.nlm.nih.gov/19401804 DM20LIM DI DM20LIM DM20LIM DN Bremelanotide DM20LIM MI TT0MV2T DM20LIM MN Melanocortin receptor 1 (MC1R) DM20LIM MT DTT DM20LIM MA Agonist DM20LIM RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health Human Services. 2019 DM20LIM RU https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/210557s000lbl.pdf DM20LIM DI DM20LIM DM20LIM DN Bremelanotide DM20LIM MI TTD0CIQ DM20LIM MN Melanocortin receptor 4 (MC4R) DM20LIM MT DTT DM20LIM MA Agonist DM20LIM RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health Human Services. 2019 DM20LIM RU https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/210557s000lbl.pdf DMWLC57 DI DMWLC57 DMWLC57 DN Brentuximab vedotin DMWLC57 MI DE4LYSA DMWLC57 MN Cytochrome P450 3A4 (CYP3A4) DMWLC57 MT DME DMWLC57 MA Metabolism DMWLC57 RN Brentuximab vedotin. DMWLC57 RU https://www.cancercareontario.ca/sites/ccocancercare/files/brentuximab%20vedotin.pdf DMWLC57 DI DMWLC57 DMWLC57 DN Brentuximab vedotin DMWLC57 MI TT2GM5R DMWLC57 MN Lymphocyte activation antigen CD30 (TNFRSF8) DMWLC57 MT DTT DMWLC57 MA Modulator DMWLC57 RN 2011 FDA drug approvals. Nat Rev Drug Discov. 2012 Feb 1;11(2):91-4. DMWLC57 RU https://pubmed.ncbi.nlm.nih.gov/22293555 DM1FX74 DI DM1FX74 DM1FX74 DN Bretylium DM1FX74 MI TTR6W5O DM1FX74 MN Adrenergic receptor beta-1 (ADRB1) DM1FX74 MT DTT DM1FX74 MA Antagonist DM1FX74 RN Components of functional sympathetic control of heart rate in neonatal rats. Am J Physiol. 1985 May;248(5 Pt 2):R601-10. DM1FX74 RU https://pubmed.ncbi.nlm.nih.gov/2859811 DM1FX74 DI DM1FX74 DM1FX74 DN Bretylium DM1FX74 MI DT3BA8L DM1FX74 MN Sodium-dependent dopamine transporter (SLC6A3) DM1FX74 MT DTP DM1FX74 MA Substrate DM1FX74 RN Which form of dopamine is the substrate for the human dopamine transporter: the cationic or the uncharged species? J Biol Chem. 1999 Feb 19;274(8):4876-82. DM1FX74 RU http://www.ncbi.nlm.nih.gov/pubmed/9988729 DM7W94S DI DM7W94S DM7W94S DN Brigatinib DM7W94S MI TTPMQSO DM7W94S MN ALK tyrosine kinase receptor (ALK) DM7W94S MT DTT DM7W94S MA Inhibitor DM7W94S RN 2017 FDA drug approvals.Nat Rev Drug Discov. 2018 Feb;17(2):81-85. DM7W94S RU https://pubmed.ncbi.nlm.nih.gov/29348678 DM7W94S DI DM7W94S DM7W94S DN Brigatinib DM7W94S MI DTKVEXO DM7W94S MN ATP-binding cassette sub-family B member 5 (ABCB5) DM7W94S MT DTP DM7W94S MA Substrate DM7W94S RN NDA/BLA Multidisciplinary Review and Evaluation of ALUNBRIG (brigatinib) From FDA. DM7W94S RU https://www.accessdata.fda.gov/drugsatfda_docs/nda/2017/208772Orig1s000MultidisciplineR.pdf DM7W94S DI DM7W94S DM7W94S DN Brigatinib DM7W94S MI DTI7UX6 DM7W94S MN Breast cancer resistance protein (ABCG2) DM7W94S MT DTP DM7W94S MA Substrate DM7W94S RN NDA/BLA Multidisciplinary Review and Evaluation of ALUNBRIG (brigatinib) From FDA. DM7W94S RU https://www.accessdata.fda.gov/drugsatfda_docs/nda/2017/208772Orig1s000MultidisciplineR.pdf DM7W94S DI DM7W94S DM7W94S DN Brigatinib DM7W94S MI DES5XRU DM7W94S MN Cytochrome P450 2C8 (CYP2C8) DM7W94S MT DME DM7W94S MA Metabolism DM7W94S RN Brigatinib: first global approval. Drugs. 2017 Jul;77(10):1131-1135. DM7W94S RU https://www.ncbi.nlm.nih.gov/pubmed/?term=28597393 DMBR01X DI DMBR01X DMBR01X DN Brilinta DMBR01X MI DE4LYSA DMBR01X MN Cytochrome P450 3A4 (CYP3A4) DMBR01X MT DME DMBR01X MA Metabolism DMBR01X RN Absorption, distribution, metabolism, and excretion of ticagrelor in healthy subjects. Drug Metab Dispos. 2010 Sep;38(9):1514-21. DMBR01X RU https://www.ncbi.nlm.nih.gov/pubmed/?term=20551239 DMBR01X DI DMBR01X DMBR01X DN Brilinta DMBR01X MI TTZ1DT0 DMBR01X MN P2Y purinoceptor 12 (P2RY12) DMBR01X MT DTT DMBR01X MA Antagonist DMBR01X RN Clinical pipeline report, company report or official report of AstraZeneca (2009). DMBR01X RU http://www.astrazeneca.com/_mshost3690701/content/resources/media/investors/AZN-Q2-2009/AZN-Q2-2009-Pipeline.pdf DMBR01X DI DMBR01X DMBR01X DN Brilinta DMBR01X MI DTUGYRD DMBR01X MN P-glycoprotein 1 (ABCB1) DMBR01X MT DTP DMBR01X MA Substrate DMBR01X RN KEGG: new perspectives on genomes, pathways, diseases and drugs. Nucleic Acids Res. 2017 Jan 4;45(D1):D353-D361. (dg:DG01665) DMBR01X RU https://www.kegg.jp/dbget-bin/www_bget?dg:DG01665 DMQLT4N DI DMQLT4N DMQLT4N DN Brimonidine DMQLT4N MI TTQ8AFT DMQLT4N MN Adrenergic receptor Alpha-2 (ADRA2) DMQLT4N MT DTT DMQLT4N MA Agonist DMQLT4N RN Increased alpha2-adrenergic constriction of isolated arterioles in diffuse scleroderma. Arthritis Rheum. 2000 Aug;43(8):1886-90. DMQLT4N RU https://pubmed.ncbi.nlm.nih.gov/10943881 DMQLT4N DI DMQLT4N DMQLT4N DN Brimonidine DMQLT4N MI TT2NUT5 DMQLT4N MN Adrenergic receptor alpha-2C (ADRA2C) DMQLT4N MT DTT DMQLT4N MA Modulator DMQLT4N RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 520). DMQLT4N RU http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=520 DMBAPFG DI DMBAPFG DMBAPFG DN Brinzolamide DMBAPFG MI TTZHA0O DMBAPFG MN Carbonic anhydrase IV (CA-IV) DMBAPFG MT DTT DMBAPFG MA Modulator DMBAPFG RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. DMBAPFG RU https://www.fda.gov/ DMBAPFG DI DMBAPFG DMBAPFG DN Brinzolamide DMBAPFG MI DE4LYSA DMBAPFG MN Cytochrome P450 3A4 (CYP3A4) DMBAPFG MT DME DMBAPFG MA Metabolism DMBAPFG RN Summary of information on human CYP enzymes: human P450 metabolism data. Drug Metab Rev. 2002 Feb-May;34(1-2):83-448. DMBAPFG RU https://www.ncbi.nlm.nih.gov/pubmed/?term=11996015 DMSEPK8 DI DMSEPK8 DMSEPK8 DN Brivaracetam DMSEPK8 MI DEPKLMQ DMSEPK8 MN Cytochrome P450 2B6 (CYP2B6) DMSEPK8 MT DME DMSEPK8 MA Metabolism DMSEPK8 RN Pharmacokinetics and metabolism of 14C-brivaracetam, a novel SV2A ligand, in healthy subjects. Drug Metab Dispos. 2008 Jan;36(1):36-45. DMSEPK8 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=17908923 DMSEPK8 DI DMSEPK8 DMSEPK8 DN Brivaracetam DMSEPK8 MI DE5IED8 DMSEPK8 MN Cytochrome P450 2C9 (CYP2C9) DMSEPK8 MT DME DMSEPK8 MA Metabolism DMSEPK8 RN Effect of gemfibrozil on the metabolism of brivaracetam in vitro and in human subjects. Drug Metab Dispos. 2012 Aug;40(8):1466-72. DMSEPK8 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=22538270 DMSEPK8 DI DMSEPK8 DMSEPK8 DN Brivaracetam DMSEPK8 MI DEGTFWK DMSEPK8 MN Mephenytoin 4-hydroxylase (CYP2C19) DMSEPK8 MT DME DMSEPK8 MA Metabolism DMSEPK8 RN Pharmacokinetics and metabolism of 14C-brivaracetam, a novel SV2A ligand, in healthy subjects. Drug Metab Dispos. 2008 Jan;36(1):36-45. DMSEPK8 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=17908923 DMSEPK8 DI DMSEPK8 DMSEPK8 DN Brivaracetam DMSEPK8 MI TTT3P91 DMSEPK8 MN Synaptic vesicle glycoprotein 2A (SV2A) DMSEPK8 MT DTT DMSEPK8 MA Inhibitor DMSEPK8 RN Pharmacological management of epilepsy: recent advances and future prospects. Drugs. 2008;68(14):1925-39. DMSEPK8 RU https://pubmed.ncbi.nlm.nih.gov/18778117 DMASDQ6 DI DMASDQ6 DMASDQ6 DN Brodalumab DMASDQ6 MI TT69OHW DMASDQ6 MN Interleukin 17 receptor (IL17R) DMASDQ6 MT DTT DMASDQ6 MA Antagonist DMASDQ6 RN 2017 FDA drug approvals.Nat Rev Drug Discov. 2018 Feb;17(2):81-85. DMASDQ6 RU https://pubmed.ncbi.nlm.nih.gov/29348678 DMASDQ6 DI DMASDQ6 DMASDQ6 DN Brodalumab DMASDQ6 MI TTG0MT6 DMASDQ6 MN Interleukin-17 (IL17) DMASDQ6 MT DTT DMASDQ6 MA Modulator DMASDQ6 RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. DMASDQ6 RU https://www.fda.gov/ DMW8QNG DI DMW8QNG DMW8QNG DN Brolucizumab DMW8QNG MI TT9HKJA DMW8QNG MN Vascular endothelial growth factor (VEGF) DMW8QNG MT DTT DMW8QNG MA Inhibitor DMW8QNG RN Brolucizumab: First Approval. Drugs. 2019 Dec;79(18):1997-2000. DMW8QNG RU https://pubmed.ncbi.nlm.nih.gov/31768932 DMW8QNG DI DMW8QNG DMW8QNG DN Brolucizumab DMW8QNG MI TTOHSBA DMW8QNG MN Vascular endothelial growth factor A (VEGFA) DMW8QNG MT DTT DMW8QNG MA Inhibitor DMW8QNG RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health Human Services. 2019 DMW8QNG RU https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/761125s000lbl.pdf DMY9TCW DI DMY9TCW DMY9TCW DN Bromazepam DMY9TCW MI DEJGDUW DMY9TCW MN Cytochrome P450 1A2 (CYP1A2) DMY9TCW MT DME DMY9TCW MA Metabolism DMY9TCW RN Selective serotonin reuptake inhibitors and CNS drug interactions. A critical review of the evidence. Clin Pharmacokinet. 1997 Dec;33(6):454-71. DMY9TCW RU https://www.ncbi.nlm.nih.gov/pubmed/?term=9435993 DMY9TCW DI DMY9TCW DMY9TCW DN Bromazepam DMY9TCW MI TTAN6JD DMY9TCW MN Glutamate receptor AMPA (GRIA) DMY9TCW MT DTT DMY9TCW MA Binder DMY9TCW RN Glutamatergic and GABAergic modulations of ultrasonic vocalizations during maternal separation distress in mouse pups. Psychopharmacology (Berl). 2009 May;204(1):61-71. DMY9TCW RU https://pubmed.ncbi.nlm.nih.gov/19099296 DMY9TCW DI DMY9TCW DMY9TCW DN Bromazepam DMY9TCW MI DEGTFWK DMY9TCW MN Mephenytoin 4-hydroxylase (CYP2C19) DMY9TCW MT DME DMY9TCW MA Metabolism DMY9TCW RN Selective serotonin reuptake inhibitors and CNS drug interactions. A critical review of the evidence. Clin Pharmacokinet. 1997 Dec;33(6):454-71. DMY9TCW RU https://www.ncbi.nlm.nih.gov/pubmed/?term=9435993 DMKB79O DI DMKB79O DMKB79O DN Bromfenac DMKB79O MI DES5XRU DMKB79O MN Cytochrome P450 2C8 (CYP2C8) DMKB79O MT DME DMKB79O MA Metabolism DMKB79O RN Metabolite profiling and reaction phenotyping for the in vitro assessment of the bioactivation of bromfenac. Chem Res Toxicol. 2020 Jan 21;33(1):249-257. DMKB79O RU https://www.ncbi.nlm.nih.gov/pubmed/?term=31815452 DMKB79O DI DMKB79O DMKB79O DN Bromfenac DMKB79O MI DE5IED8 DMKB79O MN Cytochrome P450 2C9 (CYP2C9) DMKB79O MT DME DMKB79O MA Metabolism DMKB79O RN Metabolite profiling and reaction phenotyping for the in vitro assessment of the bioactivation of bromfenac. Chem Res Toxicol. 2020 Jan 21;33(1):249-257. DMKB79O RU https://www.ncbi.nlm.nih.gov/pubmed/?term=31815452 DMKB79O DI DMKB79O DMKB79O DN Bromfenac DMKB79O MI DEGTFWK DMKB79O MN Mephenytoin 4-hydroxylase (CYP2C19) DMKB79O MT DME DMKB79O MA Metabolism DMKB79O RN Metabolite profiling and reaction phenotyping for the in vitro assessment of the bioactivation of bromfenac. Chem Res Toxicol. 2020 Jan 21;33(1):249-257. DMKB79O RU https://www.ncbi.nlm.nih.gov/pubmed/?term=31815452 DMKB79O DI DMKB79O DMKB79O DN Bromfenac DMKB79O MI DT3D8F0 DMKB79O MN Organic anion transporting polypeptide 1B1 (SLCO1B1) DMKB79O MT DTP DMKB79O MA Substrate DMKB79O RN Organic Anion Transporter 2-Mediated Hepatic Uptake Contributes to the Clearance of High-Permeability-Low-Molecular-Weight Acid and Zwitterion Drugs: Evaluation Using 25 Drugs. J Pharmacol Exp Ther. 2018 Nov;367(2):322-334. DMKB79O RU http://www.ncbi.nlm.nih.gov/pubmed/30135178 DMKB79O DI DMKB79O DMKB79O DN Bromfenac DMKB79O MI TT8NGED DMKB79O MN Prostaglandin G/H synthase 1 (COX-1) DMKB79O MT DTT DMKB79O MA Inhibitor DMKB79O RN Comparison of cyclooxygenase inhibitory activity and ocular anti-inflammatory effects of ketorolac tromethamine and bromfenac sodium. Curr Med Res Opin. 2006 Jun;22(6):1133-40. DMKB79O RU https://pubmed.ncbi.nlm.nih.gov/16846546 DMKB79O DI DMKB79O DMKB79O DN Bromfenac DMKB79O MI DEB3CV1 DMKB79O MN UDP-glucuronosyltransferase 2B7 (UGT2B7) DMKB79O MT DME DMKB79O MA Metabolism DMKB79O RN Metabolite profiling and reaction phenotyping for the in vitro assessment of the bioactivation of bromfenac. Chem Res Toxicol. 2020 Jan 21;33(1):249-257. DMKB79O RU https://www.ncbi.nlm.nih.gov/pubmed/?term=31815452 DMVE3TK DI DMVE3TK DMVE3TK DN Bromocriptine DMVE3TK MI DE4LYSA DMVE3TK MN Cytochrome P450 3A4 (CYP3A4) DMVE3TK MT DME DMVE3TK MA Metabolism DMVE3TK RN Kinetics of dithionite-dependent reduction of cytochrome P450 3A4: heterogeneity of the enzyme caused by its oligomerization. Biochemistry. 2005 Oct 25;44(42):13902-13. DMVE3TK RU https://www.ncbi.nlm.nih.gov/pubmed/?term=16229479 DMVE3TK DI DMVE3TK DMVE3TK DN Bromocriptine DMVE3TK MI TTEX248 DMVE3TK MN Dopamine D2 receptor (D2R) DMVE3TK MT DTT DMVE3TK MA Agonist DMVE3TK RN Silymarin BIO-C, an extract from Silybum marianum fruits, induces hyperprolactinemia in intact female rats. Phytomedicine. 2009 Sep;16(9):839-44. DMVE3TK RU https://pubmed.ncbi.nlm.nih.gov/19303749 DMVE3TK DI DMVE3TK DMVE3TK DN Bromocriptine DMVE3TK MI DTUGYRD DMVE3TK MN P-glycoprotein 1 (ABCB1) DMVE3TK MT DTP DMVE3TK MA Substrate DMVE3TK RN Improving the prediction of the brain disposition for orally administered drugs using BDDCS. Adv Drug Deliv Rev. 2012 Jan;64(1):95-109. DMVE3TK RU https://doi.org/10.1016/j.addr.2011.12.008 DMNDJT5 DI DMNDJT5 DMNDJT5 DN Bromodiphenhydramine DMNDJT5 MI TTTIBOJ DMNDJT5 MN Histamine H1 receptor (H1R) DMNDJT5 MT DTT DMNDJT5 MA Antagonist DMNDJT5 RN Studies on synergism between penicillins and ambodryl (bromodiphenhydramine HCl), an antihistamine with antimicrobial property. Indian J Exp Biol. 1990 Mar;28(3):253-8. DMNDJT5 RU https://pubmed.ncbi.nlm.nih.gov/1973150 DM24XYQ DI DM24XYQ DM24XYQ DN Bromperidol DM24XYQ MI DE4LYSA DM24XYQ MN Cytochrome P450 3A4 (CYP3A4) DM24XYQ MT DME DM24XYQ MA Metabolism DM24XYQ RN CYP3A is responsible for N-dealkylation of haloperidol and bromperidol and oxidation of their reduced forms by human liver microsomes. Life Sci. 2000 Nov 3;67(24):2913-20. DM24XYQ RU https://www.ncbi.nlm.nih.gov/pubmed/?term=11133003 DMFOVSD DI DMFOVSD DMFOVSD DN Brompheniramine DMFOVSD MI TTTIBOJ DMFOVSD MN Histamine H1 receptor (H1R) DMFOVSD MT DTT DMFOVSD MA Antagonist DMFOVSD RN Histamine-induced venodilation in human beings involves both H1 and H2 receptor subtypes. J Allergy Clin Immunol. 1994 Mar;93(3):606-14. DMFOVSD RU https://pubmed.ncbi.nlm.nih.gov/8151062 DMXKZT3 DI DMXKZT3 DMXKZT3 DN Buclizine DMXKZT3 MI TTTIBOJ DMXKZT3 MN Histamine H1 receptor (H1R) DMXKZT3 MT DTT DMXKZT3 MA Antagonist DMXKZT3 RN Toxicologic and clinical appraisal of buclizine, a new antihistaminic compound. J Allergy. 1956 Jan;27(1):63-7. DMXKZT3 RU https://pubmed.ncbi.nlm.nih.gov/13294975 DMJIBAW DI DMJIBAW DMJIBAW DN Budesonide DMJIBAW MI DE4LYSA DMJIBAW MN Cytochrome P450 3A4 (CYP3A4) DMJIBAW MT DME DMJIBAW MA Metabolism DMJIBAW RN No relevant effect of ursodeoxycholic acid on cytochrome P450 3A metabolism in primary biliary cirrhosis. Hepatology. 2005 Mar;41(3):595-602. DMJIBAW RU https://www.ncbi.nlm.nih.gov/pubmed/?term=15726657 DMJIBAW DI DMJIBAW DMJIBAW DN Budesonide DMJIBAW MI TTYRL6O DMJIBAW MN Glucocorticoid receptor (NR3C1) DMJIBAW MT DTT DMJIBAW MA Antagonist DMJIBAW RN PXR-mediated induction of human CYP3A4 and mouse Cyp3a11 by the glucocorticoid budesonide. Eur J Pharm Sci. 2009 Mar 2;36(4-5):565-71. DMJIBAW RU https://pubmed.ncbi.nlm.nih.gov/19138736 DMJIBAW DI DMJIBAW DMJIBAW DN Budesonide DMJIBAW MI DEYWLRK DMJIBAW MN Sulfotransferase 1A1 (SULT1A1) DMJIBAW MT DME DMJIBAW MA Metabolism DMJIBAW RN Sulfation of budesonide by human cytosolic sulfotransferase, dehydroepiandrosterone-sulfotransferase (DHEA-ST). Drug Metab Dispos. 2002 May;30(5):582-5. DMJIBAW RU https://www.ncbi.nlm.nih.gov/pubmed/?term=11950791 DMODHQI DI DMODHQI DMODHQI DN Budipine DMODHQI MI TTGP7BY DMODHQI MN Monoamine oxidase type B (MAO-B) DMODHQI MT DTT DMODHQI MA Modulator DMODHQI RN Multiple mechanisms of action: the pharmacological profile of budipine. J Neural Transm Suppl. 1999;56:83-105. DMODHQI RU https://pubmed.ncbi.nlm.nih.gov/10370904 DMG1OPF DI DMG1OPF DMG1OPF DN Buflomedil DMG1OPF MI DECB0K3 DMG1OPF MN Cytochrome P450 2D6 (CYP2D6) DMG1OPF MT DME DMG1OPF MA Metabolism DMG1OPF RN DMW/ISSX 2000 Meeting. The Drug Metabolism Workshop/International Society for the Study of Xenobiotics. St. Andrews, Scotland, June 11-16, 2000. Abstracts. Drug Metab Rev. 2000;32 Suppl 1:1-136. DMG1OPF RU https://www.ncbi.nlm.nih.gov/pubmed/?term=10909680 DMG1OPF DI DMG1OPF DMG1OPF DN Buflomedil DMG1OPF MI DEGTFWK DMG1OPF MN Mephenytoin 4-hydroxylase (CYP2C19) DMG1OPF MT DME DMG1OPF MA Metabolism DMG1OPF RN Summary of information on human CYP enzymes: human P450 metabolism data. Drug Metab Rev. 2002 Feb-May;34(1-2):83-448. DMG1OPF RU https://www.ncbi.nlm.nih.gov/pubmed/?term=11996015 DMX82DO DI DMX82DO DMX82DO DN Buformin DMX82DO MI DTT79CX DMX82DO MN Organic cation transporter 1 (SLC22A1) DMX82DO MT DTP DMX82DO MA Substrate DMX82DO RN Human intestinal transporter database: QSAR modeling and virtual profiling of drug uptake, efflux and interactions. Pharm Res. 2013 Apr;30(4):996-1007. DMX82DO RU https://doi.org/10.1007/s11095-012-0935-x DMJUVE6 DI DMJUVE6 DMJUVE6 DN Bulevirtide DMJUVE6 MI TTWZRY5 DMJUVE6 MN Sodium/bile acid cotransporter (SLC10A1) DMJUVE6 MT DTT DMJUVE6 MA Inhibitor DMJUVE6 RN Bulevirtide: First Approval. Drugs. 2020 Oct;80(15):1601-1605. DMJUVE6 RU https://pubmed.ncbi.nlm.nih.gov/32926353 DMRV7H0 DI DMRV7H0 DMRV7H0 DN Bumetanide DMRV7H0 MI DT3I124 DMRV7H0 MN Monocarboxylate transporter 6 (SLC16A5) DMRV7H0 MT DTP DMRV7H0 MA Substrate DMRV7H0 RN Quercetin, Morin, Luteolin, and Phloretin Are Dietary Flavonoid Inhibitors of Monocarboxylate Transporter 6. Mol Pharm. 2017 Sep 5;14(9):2930-2936. DMRV7H0 RU http://www.ncbi.nlm.nih.gov/pubmed/28513167 DMRV7H0 DI DMRV7H0 DMRV7H0 DN Bumetanide DMRV7H0 MI DT0OC1Q DMRV7H0 MN Organic anion transporter 2 (SLC22A7) DMRV7H0 MT DTP DMRV7H0 MA Substrate DMRV7H0 RN Transport mechanism and substrate specificity of human organic anion transporter 2 (hOat2 [SLC22A7]). J Pharm Pharmacol. 2005 May;57(5):573-8. DMRV7H0 RU http://www.ncbi.nlm.nih.gov/pubmed/15901346 DMRV7H0 DI DMRV7H0 DMRV7H0 DN Bumetanide DMRV7H0 MI DTVP67E DMRV7H0 MN Organic anion transporter 3 (SLC22A8) DMRV7H0 MT DTP DMRV7H0 MA Substrate DMRV7H0 RN Interactions of human organic anion transporters with diuretics. J Pharmacol Exp Ther. 2004 Mar;308(3):1021-9. DMRV7H0 RU http://www.ncbi.nlm.nih.gov/pubmed/14610216 DMRV7H0 DI DMRV7H0 DMRV7H0 DN Bumetanide DMRV7H0 MI DT06JWZ DMRV7H0 MN Organic anion transporter 4 (SLC22A11) DMRV7H0 MT DTP DMRV7H0 MA Substrate DMRV7H0 RN Interactions of human organic anion transporters with diuretics. J Pharmacol Exp Ther. 2004 Mar;308(3):1021-9. DMRV7H0 RU http://www.ncbi.nlm.nih.gov/pubmed/14610216 DMRV7H0 DI DMRV7H0 DMRV7H0 DN Bumetanide DMRV7H0 MI TTS087L DMRV7H0 MN Solute carrier family 12 member 1 (SLC12A1) DMRV7H0 MT DTT DMRV7H0 MA Blocker DMRV7H0 RN Nerve Terminal GABAA Receptors Activate Ca2+/Calmodulin-dependent Signaling to Inhibit Voltage-gated Ca2+ Influx and Glutamate Release. J Biol Chem. 2009 Mar 27;284(13):8726-37. DMRV7H0 RU https://pubmed.ncbi.nlm.nih.gov/19141616 DMRV7H0 DI DMRV7H0 DMRV7H0 DN Bumetanide DMRV7H0 MI DT6MDC9 DMRV7H0 MN Thiazide-sensitive sodium-chloride cotransporter (SLC12A3) DMRV7H0 MT DTP DMRV7H0 MA Substrate DMRV7H0 RN Genetic variation in the renal sodium transporters NKCC2, NCC, and ENaC in relation to the effects of loop diuretic drugs. Clin Pharmacol Ther. 2007 Sep;82(3):300-9. DMRV7H0 RU http://www.ncbi.nlm.nih.gov/pubmed/17460608 DM4I8O7 DI DM4I8O7 DM4I8O7 DN Bunazosin DM4I8O7 MI TT34BHT DM4I8O7 MN Adrenergic receptor alpha-1D (ADRA1D) DM4I8O7 MT DTT DM4I8O7 MA Modulator DM4I8O7 RN Bunazosin, a selective alpha1-adrenoceptor antagonist, as an anti-glaucoma drug: effects on ocular circulation and retinal neuronal damage. Cardiovasc Drug Rev. 2005 Spring;23(1):43-56. DM4I8O7 RU https://pubmed.ncbi.nlm.nih.gov/15867947 DM4PRFC DI DM4PRFC DM4PRFC DN Bupivacaine DM4PRFC MI DECB0K3 DM4PRFC MN Cytochrome P450 2D6 (CYP2D6) DM4PRFC MT DME DM4PRFC MA Metabolism DM4PRFC RN Oxidative metabolism of bupivacaine into pipecolylxylidine in humans is mainly catalyzed by CYP3A. Drug Metab Dispos. 2000 Apr;28(4):383-5. DM4PRFC RU https://www.ncbi.nlm.nih.gov/pubmed/?term=10725304 DM4PRFC DI DM4PRFC DM4PRFC DN Bupivacaine DM4PRFC MI DE4LYSA DM4PRFC MN Cytochrome P450 3A4 (CYP3A4) DM4PRFC MT DME DM4PRFC MA Metabolism DM4PRFC RN Oxidative metabolism of bupivacaine into pipecolylxylidine in humans is mainly catalyzed by CYP3A. Drug Metab Dispos. 2000 Apr;28(4):383-5. DM4PRFC RU https://www.ncbi.nlm.nih.gov/pubmed/?term=10725304 DM4PRFC DI DM4PRFC DM4PRFC DN Bupivacaine DM4PRFC MI DEGTFWK DM4PRFC MN Mephenytoin 4-hydroxylase (CYP2C19) DM4PRFC MT DME DM4PRFC MA Metabolism DM4PRFC RN Oxidative metabolism of bupivacaine into pipecolylxylidine in humans is mainly catalyzed by CYP3A. Drug Metab Dispos. 2000 Apr;28(4):383-5. DM4PRFC RU https://www.ncbi.nlm.nih.gov/pubmed/?term=10725304 DM4PRFC DI DM4PRFC DM4PRFC DN Bupivacaine DM4PRFC MI TT90XZ8 DM4PRFC MN Voltage-gated sodium channel alpha Nav1.8 (SCN10A) DM4PRFC MT DTT DM4PRFC MA Modulator DM4PRFC RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. DM4PRFC RU https://www.fda.gov/ DMPRI8G DI DMPRI8G DMPRI8G DN Buprenorphine DMPRI8G MI DEZMWRE DMPRI8G MN Cytochrome P450 2C18 (CYP2C18) DMPRI8G MT DME DMPRI8G MA Metabolism DMPRI8G RN In vitro metabolism study of buprenorphine: evidence for new metabolic pathways. Drug Metab Dispos. 2005 May;33(5):689-95. DMPRI8G RU https://www.ncbi.nlm.nih.gov/pubmed/?term=15743975 DMPRI8G DI DMPRI8G DMPRI8G DN Buprenorphine DMPRI8G MI DES5XRU DMPRI8G MN Cytochrome P450 2C8 (CYP2C8) DMPRI8G MT DME DMPRI8G MA Metabolism DMPRI8G RN Buprenorphine in cancer pain. Support Care Cancer. 2005 Nov;13(11):878-87. DMPRI8G RU https://www.ncbi.nlm.nih.gov/pubmed/?term=16010532 DMPRI8G DI DMPRI8G DMPRI8G DN Buprenorphine DMPRI8G MI DE5IED8 DMPRI8G MN Cytochrome P450 2C9 (CYP2C9) DMPRI8G MT DME DMPRI8G MA Metabolism DMPRI8G RN Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. DMPRI8G RU https://www.ncbi.nlm.nih.gov/pubmed/?term=19515014 DMPRI8G DI DMPRI8G DMPRI8G DN Buprenorphine DMPRI8G MI DECB0K3 DMPRI8G MN Cytochrome P450 2D6 (CYP2D6) DMPRI8G MT DME DMPRI8G MA Metabolism DMPRI8G RN Effect of nonspecific binding to microsomes and metabolic elimination of buprenorphine on the inhibition of cytochrome P4502D6. Biol Pharm Bull. 2005 Feb;28(2):212-6. DMPRI8G RU https://www.ncbi.nlm.nih.gov/pubmed/?term=15684471 DMPRI8G DI DMPRI8G DMPRI8G DN Buprenorphine DMPRI8G MI DE4LYSA DMPRI8G MN Cytochrome P450 3A4 (CYP3A4) DMPRI8G MT DME DMPRI8G MA Metabolism DMPRI8G RN Drug interactions of clinical importance among the opioids, methadone and buprenorphine, and other frequently prescribed medications: a review. Am J Addict. 2010 Jan-Feb;19(1):4-16. DMPRI8G RU https://www.ncbi.nlm.nih.gov/pubmed/?term=20132117 DMPRI8G DI DMPRI8G DMPRI8G DN Buprenorphine DMPRI8G MI DEIBDNY DMPRI8G MN Cytochrome P450 3A5 (CYP3A5) DMPRI8G MT DME DMPRI8G MA Metabolism DMPRI8G RN Buprenorphine pharmacology review: update on transmucosal and long-acting formulations. J Addict Med. 2019 Mar/Apr;13(2):93-103. DMPRI8G RU https://www.ncbi.nlm.nih.gov/pubmed/?term=30531584 DMPRI8G DI DMPRI8G DMPRI8G DN Buprenorphine DMPRI8G MI DERD86B DMPRI8G MN Cytochrome P450 3A7 (CYP3A7) DMPRI8G MT DME DMPRI8G MA Metabolism DMPRI8G RN Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. DMPRI8G RU https://www.ncbi.nlm.nih.gov/pubmed/?term=19515014 DMPRI8G DI DMPRI8G DMPRI8G DN Buprenorphine DMPRI8G MI TTKWM86 DMPRI8G MN Opioid receptor mu (MOP) DMPRI8G MT DTT DMPRI8G MA Agonist DMPRI8G RN Buprenorphine is a weak partial agonist that inhibits opioid receptor desensitization. J Neurosci. 2009 Jun 3;29(22):7341-8. DMPRI8G RU https://pubmed.ncbi.nlm.nih.gov/19494155 DMPRI8G DI DMPRI8G DMPRI8G DN Buprenorphine DMPRI8G MI DEYGVN4 DMPRI8G MN UDP-glucuronosyltransferase 1A1 (UGT1A1) DMPRI8G MT DME DMPRI8G MA Metabolism DMPRI8G RN Contribution of the different UDP-glucuronosyltransferase (UGT) isoforms to buprenorphine and norbuprenorphine metabolism and relationship with the main UGT polymorphisms in a bank of human liver microsomes. Drug Metab Dispos. 2010 Jan;38(1):40-5. DMPRI8G RU https://www.ncbi.nlm.nih.gov/pubmed/?term=19841060 DMBQEGT DI DMBQEGT DMBQEGT DN Buprenorphine + naloxone DMBQEGT MI TTKWM86 DMBQEGT MN Opioid receptor mu (MOP) DMBQEGT MT DTT DMBQEGT MA Agonist DMBQEGT RN Abstracts of Poster Presentations: CNS Summit 2013: November 14-17, 2013 Boca Raton, Florida. Innov Clin Neurosci. 2013 Nov-Dec; 10(11-12 Suppl B): 1-18. DMBQEGT RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4051412/ DM5PCS7 DI DM5PCS7 DM5PCS7 DN Bupropion DM5PCS7 MI DTI7UX6 DM5PCS7 MN Breast cancer resistance protein (ABCG2) DM5PCS7 MT DTP DM5PCS7 MA Substrate DM5PCS7 RN Role of transporter-mediated efflux in the placental biodisposition of bupropion and its metabolite, OH-bupropion. Biochem Pharmacol. 2010 Oct 1;80(7):1080-6. DM5PCS7 RU http://www.ncbi.nlm.nih.gov/pubmed/20599802 DM5PCS7 DI DM5PCS7 DM5PCS7 DN Bupropion DM5PCS7 MI DEPKLMQ DM5PCS7 MN Cytochrome P450 2B6 (CYP2B6) DM5PCS7 MT DME DM5PCS7 MA Metabolism DM5PCS7 RN Laparoscopic Roux-en-Y gastric bypass surgery influenced pharmacokinetics of several drugs given as a cocktail with the highest impact observed for CYP1A2, CYP2C8 and CYP2E1 substrates. Basic Clin Pharmacol Toxicol. 2019 Aug;125(2):123-132. DM5PCS7 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=30916845 DM5PCS7 DI DM5PCS7 DM5PCS7 DN Bupropion DM5PCS7 MI DE5IED8 DM5PCS7 MN Cytochrome P450 2C9 (CYP2C9) DM5PCS7 MT DME DM5PCS7 MA Metabolism DM5PCS7 RN Product Monograph of Wellbutrin SR(Bupropion Hydrochloride). DM5PCS7 RU https://pdf.hres.ca/dpd_pm/00038603.PDF DM5PCS7 DI DM5PCS7 DM5PCS7 DN Bupropion DM5PCS7 MI DECB0K3 DM5PCS7 MN Cytochrome P450 2D6 (CYP2D6) DM5PCS7 MT DME DM5PCS7 MA Metabolism DM5PCS7 RN In vitro to in vivo extrapolation of the complex drug-drug interaction of bupropion and its metabolites with CYP2D6; simultaneous reversible inhibition and CYP2D6 downregulation. Biochem Pharmacol. 2017 Jan 1;123:85-96. DM5PCS7 RU https://www.ncbi.nlm.nih.gov/pubmed/27836670 DM5PCS7 DI DM5PCS7 DM5PCS7 DN Bupropion DM5PCS7 MI DEVDYN7 DM5PCS7 MN Cytochrome P450 2E1 (CYP2E1) DM5PCS7 MT DME DM5PCS7 MA Metabolism DM5PCS7 RN Validation of bupropion hydroxylation as a selective marker of human cytochrome P450 2B6 catalytic activity. Drug Metab Dispos. 2000 Oct;28(10):1222-30. DM5PCS7 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=10997944 DM5PCS7 DI DM5PCS7 DM5PCS7 DN Bupropion DM5PCS7 MI TTAWNKZ DM5PCS7 MN Norepinephrine transporter (NET) DM5PCS7 MT DTT DM5PCS7 MA Inhibitor DM5PCS7 RN Clinically relevant drug interactions with new generation antidepressants and antipsychotics. Ther Umsch. 2009 Jun;66(6):485-92. DM5PCS7 RU https://pubmed.ncbi.nlm.nih.gov/19496045 DM5PCS7 DI DM5PCS7 DM5PCS7 DN Bupropion DM5PCS7 MI DTUGYRD DM5PCS7 MN P-glycoprotein 1 (ABCB1) DM5PCS7 MT DTP DM5PCS7 MA Substrate DM5PCS7 RN Sertraline and its metabolite desmethylsertraline, but not bupropion or its three major metabolites, have high affinity for P-glycoprotein. Biol Pharm Bull. 2008 Feb;31(2):231-4. DM5PCS7 RU https://doi.org/10.1248/bpb.31.231 DM5PCS7 DI DM5PCS7 DM5PCS7 DN Bupropion DM5PCS7 MI TT3ROYC DM5PCS7 MN Serotonin transporter (SERT) DM5PCS7 MT DTT DM5PCS7 MA Inhibitor DM5PCS7 RN Clinically relevant drug interactions with new generation antidepressants and antipsychotics. Ther Umsch. 2009 Jun;66(6):485-92. DM5PCS7 RU https://pubmed.ncbi.nlm.nih.gov/19496045 DMKUOQV DI DMKUOQV DMKUOQV DN Burosumab DMKUOQV MI TT2IZ4K DMKUOQV MN Fibroblast growth factor-23 (FGF23) DMKUOQV MT DTT DMKUOQV MA Modulator DMKUOQV RN 2018 FDA drug approvals.Nat Rev Drug Discov. 2019 Feb;18(2):85-89. DMKUOQV RU https://pubmed.ncbi.nlm.nih.gov/30710142 DMBS632 DI DMBS632 DMBS632 DN Buspirone DMBS632 MI TTSQIFT DMBS632 MN 5-HT 1A receptor (HTR1A) DMBS632 MT DTT DMBS632 MA Agonist DMBS632 RN Interactions between corticotropin-releasing hormone and serotonin: implications for the aetiology and treatment of anxiety disorders. Handb Exp Pharmacol. 2005;(169):181-204. DMBS632 RU https://pubmed.ncbi.nlm.nih.gov/16594259 DMBS632 DI DMBS632 DMBS632 DN Buspirone DMBS632 MI DE4OGUF DMBS632 MN Cytochrome P450 102A1 (cyp102) DMBS632 MT DME DMBS632 MA Metabolism DMBS632 RN The bacterial P450 BM3: a prototype for a biocatalyst with human P450 activities. Trends Biotechnol. 2007 Jul;25(7):289-98. DMBS632 RU https://pubmed.ncbi.nlm.nih.gov/17532492 DMBS632 DI DMBS632 DMBS632 DN Buspirone DMBS632 MI DECB0K3 DMBS632 MN Cytochrome P450 2D6 (CYP2D6) DMBS632 MT DME DMBS632 MA Metabolism DMBS632 RN Cytochrome P450 3A-mediated metabolism of buspirone in human liver microsomes. Drug Metab Dispos. 2005 Apr;33(4):500-7. DMBS632 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=15640381 DMBS632 DI DMBS632 DMBS632 DN Buspirone DMBS632 MI DE4LYSA DMBS632 MN Cytochrome P450 3A4 (CYP3A4) DMBS632 MT DME DMBS632 MA Metabolism DMBS632 RN Effects of cytochrome P450 (CYP) 3A4 inhibitors on the anxiolytic action of tandospirone in rat contextual conditioned fear. Prog Neuropsychopharmacol Biol Psychiatry. 2007 May 9;31(4):926-31. DMBS632 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=17376576 DMBS632 DI DMBS632 DMBS632 DN Buspirone DMBS632 MI DEIBDNY DMBS632 MN Cytochrome P450 3A5 (CYP3A5) DMBS632 MT DME DMBS632 MA Metabolism DMBS632 RN Cytochrome P450 3A-mediated metabolism of buspirone in human liver microsomes. Drug Metab Dispos. 2005 Apr;33(4):500-7. DMBS632 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=15640381 DMBS632 DI DMBS632 DMBS632 DN Buspirone DMBS632 MI DERD86B DMBS632 MN Cytochrome P450 3A7 (CYP3A7) DMBS632 MT DME DMBS632 MA Metabolism DMBS632 RN Drug Interactions Flockhart Table DMBS632 RU https://drug-interactions.medicine.iu.edu/Main-Table.aspx DMXYJ9C DI DMXYJ9C DMXYJ9C DN Busulfan DMXYJ9C MI DE4LYSA DMXYJ9C MN Cytochrome P450 3A4 (CYP3A4) DMXYJ9C MT DME DMXYJ9C MA Metabolism DMXYJ9C RN Update: clinically significant cytochrome P-450 drug interactions. Pharmacotherapy. 1998 Jan-Feb;18(1):84-112. DMXYJ9C RU https://www.ncbi.nlm.nih.gov/pubmed/?term=9469685 DMXYJ9C DI DMXYJ9C DMXYJ9C DN Busulfan DMXYJ9C MI DE4ZHS1 DMXYJ9C MN Glutathione S-transferase alpha-1 (GSTA1) DMXYJ9C MT DME DMXYJ9C MA Metabolism DMXYJ9C RN Glutathione S-transferase M1 polymorphism: a risk factor for hepatic venoocclusive disease in bone marrow transplantation. Blood. 2004 Sep 1;104(5):1574-7. DMXYJ9C RU https://www.ncbi.nlm.nih.gov/pubmed/?term=15142875 DMXYJ9C DI DMXYJ9C DMXYJ9C DN Busulfan DMXYJ9C MI DEH49YS DMXYJ9C MN Glutathione S-transferase alpha-2 (GSTA2) DMXYJ9C MT DME DMXYJ9C MA Metabolism DMXYJ9C RN Endothelial cells do not express GSTA1: potential relevance to busulfan-mediated endothelial damage during haematopoietic stem cell transplantation. Eur J Haematol. 2008 Apr;80(4):299-302. DMXYJ9C RU https://www.ncbi.nlm.nih.gov/pubmed/?term=18194479 DMXYJ9C DI DMXYJ9C DMXYJ9C DN Busulfan DMXYJ9C MI DEYZEJA DMXYJ9C MN Glutathione S-transferase mu-1 (GSTM1) DMXYJ9C MT DME DMXYJ9C MA Metabolism DMXYJ9C RN Busulfan conjugation by glutathione S-transferases alpha, mu, and pi. Drug Metab Dispos. 1996 Sep;24(9):1015-9. DMXYJ9C RU https://www.ncbi.nlm.nih.gov/pubmed/?term=8886613 DMXYJ9C DI DMXYJ9C DMXYJ9C DN Busulfan DMXYJ9C MI DEK6079 DMXYJ9C MN Glutathione S-transferase pi (GSTP1) DMXYJ9C MT DME DMXYJ9C MA Metabolism DMXYJ9C RN Busulfan conjugation by glutathione S-transferases alpha, mu, and pi. Drug Metab Dispos. 1996 Sep;24(9):1015-9. DMXYJ9C RU https://www.ncbi.nlm.nih.gov/pubmed/?term=8886613 DMXYJ9C DI DMXYJ9C DMXYJ9C DN Busulfan DMXYJ9C MI TTUTN1I DMXYJ9C MN Human Deoxyribonucleic acid (hDNA) DMXYJ9C MT DTT DMXYJ9C MA Modulator DMXYJ9C RN DNA intrastrand cross-link at the 5'-GA-3' sequence formed by busulfan and its role in the cytotoxic effect. Cancer Sci. 2004 May;95(5):454-8. DMXYJ9C RU https://www.ncbi.nlm.nih.gov/pubmed/15132775 DMXYJ9C DI DMXYJ9C DMXYJ9C DN Busulfan DMXYJ9C MI DE31KMQ DMXYJ9C MN Microsomal glutathione S-transferase 2 (MGST2) DMXYJ9C MT DME DMXYJ9C MA Metabolism DMXYJ9C RN Overexpression of glutathione-S-transferase, MGSTII, confers resistance to busulfan and melphalan. Cancer Invest. 2005;23(1):19-25. DMXYJ9C RU https://www.ncbi.nlm.nih.gov/pubmed/?term=15779864 DMC5AST DI DMC5AST DMC5AST DN Butabarbital DMC5AST MI TT1MPAY DMC5AST MN GABA(A) receptor alpha-1 (GABRA1) DMC5AST MT DTT DMC5AST MA Antagonist DMC5AST RN DrugBank: a knowledgebase for drugs, drug actions and drug targets. Nucleic Acids Res. 2008 Jan;36(Database issue):D901-6. DMC5AST RU https://pubmed.ncbi.nlm.nih.gov/18048412 DM584TM DI DM584TM DM584TM DN Butacaine DM584TM MI TTRK8B9 DM584TM MN Sodium channel unspecific (NaC) DM584TM MT DTT DM584TM MA Modulator DM584TM RN WO patent application no. 2008,0857,11, Synergy of sodium channel blockers and calcium channel blockers. DM584TM RU http://worldwide.espacenet.com/publicationDetails/biblio?DB=worldwide.espacenet.com&II=0&ND=3&adjacent=true&locale=en_EP&FT=D&date=20080717&CC=WO&NR=2008085711A1&KC=A1 DM9J04X DI DM9J04X DM9J04X DN Butalbital DM9J04X MI TT1MPAY DM9J04X MN GABA(A) receptor alpha-1 (GABRA1) DM9J04X MT DTT DM9J04X MA Antagonist DM9J04X RN DrugBank: a knowledgebase for drugs, drug actions and drug targets. Nucleic Acids Res. 2008 Jan;36(Database issue):D901-6. DM9J04X RU https://pubmed.ncbi.nlm.nih.gov/18048412 DMOJ4ZI DI DMOJ4ZI DMOJ4ZI DN Butenafine DMOJ4ZI MI TTM9XSU DMOJ4ZI MN Candida Squalene epoxidase (Candi ERG1) DMOJ4ZI MT DTT DMOJ4ZI MA Modulator DMOJ4ZI RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. DMOJ4ZI RU https://www.fda.gov/ DM7JHX0 DI DM7JHX0 DM7JHX0 DN Butethal DM7JHX0 MI TT1MPAY DM7JHX0 MN GABA(A) receptor alpha-1 (GABRA1) DM7JHX0 MT DTT DM7JHX0 MA Antagonist DM7JHX0 RN DrugBank: a knowledgebase for drugs, drug actions and drug targets. Nucleic Acids Res. 2008 Jan;36(Database issue):D901-6. DM7JHX0 RU https://pubmed.ncbi.nlm.nih.gov/18048412 DM8SY60 DI DM8SY60 DM8SY60 DN Butoconazole DM8SY60 MI TTTSOUD DM8SY60 MN Candida Cytochrome P450 51 (Candi ERG11) DM8SY60 MT DTT DM8SY60 MA Inhibitor DM8SY60 RN Effects of terconazole and other azole antifungal agents on the sterol and carbohydrate composition of Candida albicans. Diagn Microbiol Infect Dis. 1990 Jan-Feb;13(1):31-5. DM8SY60 RU https://pubmed.ncbi.nlm.nih.gov/2184984 DM5KYPJ DI DM5KYPJ DM5KYPJ DN Butorphanol DM5KYPJ MI TT27RFC DM5KYPJ MN Opioid receptor delta (OPRD1) DM5KYPJ MT DTT DM5KYPJ MA Agonist DM5KYPJ RN Butorphanol: effects of a prototypical agonist-antagonist analgesic on kappa-opioid receptors. J Pharmacol Sci. 2005 Jun;98(2):109-16. DM5KYPJ RU https://pubmed.ncbi.nlm.nih.gov/15942128 DMZKXB7 DI DMZKXB7 DMZKXB7 DN Butylscopolamine DMZKXB7 MI TTH18TF DMZKXB7 MN Muscarinic acetylcholine receptor M5 (CHRM5) DMZKXB7 MT DTT DMZKXB7 MA Modulator DMZKXB7 RN Comparison of pharmacological effects of L- and DL-n-butyl-scopolamine in rat uterus. Yao Xue Xue Bao. 1994;29(1):24-7. DMZKXB7 RU https://pubmed.ncbi.nlm.nih.gov/8036897 DMPAZHC DI DMPAZHC DMPAZHC DN Cabazitaxel DMPAZHC MI DES5XRU DMPAZHC MN Cytochrome P450 2C8 (CYP2C8) DMPAZHC MT DME DMPAZHC MA Metabolism DMPAZHC RN DAILYMED.nlm.nih.gov: JEVTANA- cabazitaxel kit. DMPAZHC RU https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=de3d9c26-572b-4ea4-9b2d-dd58a2b3e8fa DMPAZHC DI DMPAZHC DMPAZHC DN Cabazitaxel DMPAZHC MI DE4LYSA DMPAZHC MN Cytochrome P450 3A4 (CYP3A4) DMPAZHC MT DME DMPAZHC MA Metabolism DMPAZHC RN DAILYMED.nlm.nih.gov: JEVTANA- cabazitaxel kit. DMPAZHC RU https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=de3d9c26-572b-4ea4-9b2d-dd58a2b3e8fa DMPAZHC DI DMPAZHC DMPAZHC DN Cabazitaxel DMPAZHC MI DEIBDNY DMPAZHC MN Cytochrome P450 3A5 (CYP3A5) DMPAZHC MT DME DMPAZHC MA Metabolism DMPAZHC RN DAILYMED.nlm.nih.gov: JEVTANA- cabazitaxel kit. DMPAZHC RU https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=de3d9c26-572b-4ea4-9b2d-dd58a2b3e8fa DMPAZHC DI DMPAZHC DMPAZHC DN Cabazitaxel DMPAZHC MI TTML2WA DMPAZHC MN Tubulin (TUB) DMPAZHC MT DTT DMPAZHC MA Inhibitor DMPAZHC RN Mullard A: 2010 FDA drug approvals. Nat Rev Drug Discov. 2011 Feb;10(2):82-5. DMPAZHC RU https://pubmed.ncbi.nlm.nih.gov/21283092 DMQ4HIN DI DMQ4HIN DMQ4HIN DN Cabergoline DMQ4HIN MI DE4LYSA DMQ4HIN MN Cytochrome P450 3A4 (CYP3A4) DMQ4HIN MT DME DMQ4HIN MA Metabolism DMQ4HIN RN Receptor-binding and pharmacokinetic properties of dopaminergic agonists. Curr Top Med Chem. 2008;8(12):1049-67. DMQ4HIN RU https://www.ncbi.nlm.nih.gov/pubmed/?term=18691132 DMQ4HIN DI DMQ4HIN DMQ4HIN DN Cabergoline DMQ4HIN MI TTEX248 DMQ4HIN MN Dopamine D2 receptor (D2R) DMQ4HIN MT DTT DMQ4HIN MA Agonist DMQ4HIN RN Role of D1 and D2 receptors in the regulation of voluntary movements. Bull Exp Biol Med. 2008 Jul;146(1):14-7. DMQ4HIN RU https://pubmed.ncbi.nlm.nih.gov/19145338 DMQ4HIN DI DMQ4HIN DMQ4HIN DN Cabergoline DMQ4HIN MI DTUGYRD DMQ4HIN MN P-glycoprotein 1 (ABCB1) DMQ4HIN MT DTP DMQ4HIN MA Substrate DMQ4HIN RN Polymorphisms of the drug transporter gene ABCB1 predict side effects of treatment with cabergoline in patients with PRL adenomas. Eur J Endocrinol. 2012 Sep;167(3):327-35. DMQ4HIN RU http://www.ncbi.nlm.nih.gov/pubmed/22672924 DMIYDT4 DI DMIYDT4 DMIYDT4 DN Cabozantinib DMIYDT4 MI DE5IED8 DMIYDT4 MN Cytochrome P450 2C9 (CYP2C9) DMIYDT4 MT DME DMIYDT4 MA Metabolism DMIYDT4 RN FDA Label of Cabozantinib. The 2020 official website of the U.S. Food and Drug Administration. DMIYDT4 RU https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/208692s003lbl.pdf DMIYDT4 DI DMIYDT4 DMIYDT4 DN Cabozantinib DMIYDT4 MI DE4LYSA DMIYDT4 MN Cytochrome P450 3A4 (CYP3A4) DMIYDT4 MT DME DMIYDT4 MA Metabolism DMIYDT4 RN Practical management of adverse events associated with cabozantinib treatment in patients with renal-cell carcinoma. Onco Targets Ther. 2017 Oct 19;10:5053-5064. DMIYDT4 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=29089775 DMIYDT4 DI DMIYDT4 DMIYDT4 DN Cabozantinib DMIYDT4 MI TTNDSF4 DMIYDT4 MN Proto-oncogene c-Met (MET) DMIYDT4 MT DTT DMIYDT4 MA Inhibitor DMIYDT4 RN Clinical pipeline report, company report or official report of Exelixis (2011). DMIYDT4 RU http://www.exelixis.com/pipeline DMIYDT4 DI DMIYDT4 DMIYDT4 DN Cabozantinib DMIYDT4 MI TTUTJGQ DMIYDT4 MN Vascular endothelial growth factor receptor 2 (KDR) DMIYDT4 MT DTT DMIYDT4 MA Inhibitor DMIYDT4 RN Clinical pipeline report, company report or official report of Exelixis (2011). DMIYDT4 RU http://www.exelixis.com/pipeline DMKBJWP DI DMKBJWP DMKBJWP DN Caffeine DMKBJWP MI TTK25J1 DMKBJWP MN Adenosine A1 receptor (ADORA1) DMKBJWP MT DTT DMKBJWP MA Antagonist DMKBJWP RN Caffeine as a psychomotor stimulant: mechanism of action. Cell Mol Life Sci. 2004 Apr;61(7-8):857-72. DMKBJWP RU https://pubmed.ncbi.nlm.nih.gov/15095008 DMKBJWP DI DMKBJWP DMKBJWP DN Caffeine DMKBJWP MI TTM2AOE DMKBJWP MN Adenosine A2a receptor (ADORA2A) DMKBJWP MT DTT DMKBJWP MA Antagonist DMKBJWP RN Caffeine as a psychomotor stimulant: mechanism of action. Cell Mol Life Sci. 2004 Apr;61(7-8):857-72. DMKBJWP RU https://pubmed.ncbi.nlm.nih.gov/15095008 DMKBJWP DI DMKBJWP DMKBJWP DN Caffeine DMKBJWP MI DEJGDUW DMKBJWP MN Cytochrome P450 1A2 (CYP1A2) DMKBJWP MT DME DMKBJWP MA Metabolism DMKBJWP RN Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. DMKBJWP RU https://www.ncbi.nlm.nih.gov/pubmed/?term=19515014 DMKBJWP DI DMKBJWP DMKBJWP DN Caffeine DMKBJWP MI DE9QHP6 DMKBJWP MN Cytochrome P450 1B1 (CYP1B1) DMKBJWP MT DME DMKBJWP MA Metabolism DMKBJWP RN Oxidation of xenobiotics by recombinant human cytochrome P450 1B1. Drug Metab Dispos. 1997 May;25(5):617-22. DMKBJWP RU https://www.ncbi.nlm.nih.gov/pubmed/?term=9152602 DMKBJWP DI DMKBJWP DMKBJWP DN Caffeine DMKBJWP MI DES5XRU DMKBJWP MN Cytochrome P450 2C8 (CYP2C8) DMKBJWP MT DME DMKBJWP MA Metabolism DMKBJWP RN PharmGKB summary: caffeine pathway. Pharmacogenet Genomics. 2012 May;22(5):389-95. DMKBJWP RU https://www.ncbi.nlm.nih.gov/pubmed/?term=22293536 DMKBJWP DI DMKBJWP DMKBJWP DN Caffeine DMKBJWP MI DE5IED8 DMKBJWP MN Cytochrome P450 2C9 (CYP2C9) DMKBJWP MT DME DMKBJWP MA Metabolism DMKBJWP RN Monkey liver cytochrome P450 2C9 is involved in caffeine 7-N-demethylation to form theophylline. Xenobiotica. 2013 Dec;43(12):1037-42. DMKBJWP RU https://www.ncbi.nlm.nih.gov/pubmed/?term=23679834 DMKBJWP DI DMKBJWP DMKBJWP DN Caffeine DMKBJWP MI DECB0K3 DMKBJWP MN Cytochrome P450 2D6 (CYP2D6) DMKBJWP MT DME DMKBJWP MA Metabolism DMKBJWP RN Determinants of interindividual variability and extent of CYP2D6 and CYP1A2 inhibition by paroxetine and fluvoxamine in vivo. J Clin Psychopharmacol. 1998 Jun;18(3):198-207. DMKBJWP RU https://www.ncbi.nlm.nih.gov/pubmed/?term=9617978 DMKBJWP DI DMKBJWP DMKBJWP DN Caffeine DMKBJWP MI DEVDYN7 DMKBJWP MN Cytochrome P450 2E1 (CYP2E1) DMKBJWP MT DME DMKBJWP MA Metabolism DMKBJWP RN CYP2E1 active site residues in substrate recognition sequence 5 identified by photoaffinity labeling and homology modeling. Arch Biochem Biophys. 2007 Mar 1;459(1):59-69. DMKBJWP RU https://www.ncbi.nlm.nih.gov/pubmed/?term=17222385 DMKBJWP DI DMKBJWP DMKBJWP DN Caffeine DMKBJWP MI DE4LYSA DMKBJWP MN Cytochrome P450 3A4 (CYP3A4) DMKBJWP MT DME DMKBJWP MA Metabolism DMKBJWP RN Effect of cytochrome P450 (CYP) inducers on caffeine metabolism in the rat. Pharmacol Rep. 2007 May-Jun;59(3):296-305. DMKBJWP RU https://www.ncbi.nlm.nih.gov/pubmed/?term=17652830 DMKBJWP DI DMKBJWP DMKBJWP DN Caffeine DMKBJWP MI DEZV4AP DMKBJWP MN RNA cytidine acetyltransferase (hALP) DMKBJWP MT DME DMKBJWP MA Metabolism DMKBJWP RN A population and family study of N-acetyltransferase using caffeine urinary metabolites. Clin Pharmacol Ther. 1993 Aug;54(2):134-41. DMKBJWP RU https://www.ncbi.nlm.nih.gov/pubmed/?term=8354022 DMQZBXI DI DMQZBXI DMQZBXI DN Calaspargase pegol DMQZBXI MI TT4WT91 DMQZBXI MN Asparaginase (ASRGL1) DMQZBXI MT DTT DMQZBXI MA Inhibitor DMQZBXI RN Pharmacokinetic and pharmacodynamic properties of calaspargase pegol Escherichia coli L-asparaginase in the treatment of patients with acute lymphoblastic leukemia: results from Children's Oncology Group Study AALL07P4. J Clin Oncol. 2014 Dec 1;32(34):3874-82. DMQZBXI RU https://pubmed.ncbi.nlm.nih.gov/25348002 DMN4CV5 DI DMN4CV5 DMN4CV5 DN Calcidiol DMN4CV5 MI DE3FYEM DMN4CV5 MN Calcidiol 1-monooxygenase (CYP27B1) DMN4CV5 MT DME DMN4CV5 MA Metabolism DMN4CV5 RN Cytochromes P450 are essential players in the vitamin D signaling system. Biochim Biophys Acta. 2011 Jan;1814(1):186-99. DMN4CV5 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=20619365 DMN4CV5 DI DMN4CV5 DMN4CV5 DN Calcidiol DMN4CV5 MI DEFI12S DMN4CV5 MN Vitamin D(3) 24-hydroxylase (CYP24A1) DMN4CV5 MT DME DMN4CV5 MA Metabolism DMN4CV5 RN Asthma families show transmission disequilibrium of gene variants in the vitamin D metabolism and signalling pathway. Respir Res. 2006 Apr 6;7:60. DMN4CV5 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=16600026 DMN4CV5 DI DMN4CV5 DMN4CV5 DN Calcidiol DMN4CV5 MI TTK59TV DMN4CV5 MN Vitamin D3 receptor (VDR) DMN4CV5 MT DTT DMN4CV5 MA Antagonist DMN4CV5 RN Vitamin D in health and disease. Clin J Am Soc Nephrol. 2008 Sep;3(5):1535-41. DMN4CV5 RU https://pubmed.ncbi.nlm.nih.gov/18525006 DM03CP7 DI DM03CP7 DM03CP7 DN Calcipotriol DM03CP7 MI TTK59TV DM03CP7 MN Vitamin D3 receptor (VDR) DM03CP7 MT DTT DM03CP7 MA Antagonist DM03CP7 RN Cellular and molecular mechanisms involved in the action of vitamin D analogs targeting vitiligo depigmentation. Curr Drug Targets. 2008 Apr;9(4):345-59. DM03CP7 RU https://pubmed.ncbi.nlm.nih.gov/18393827 DM0N9WA DI DM0N9WA DM0N9WA DN Calcitonin Human DM0N9WA MI TTLWS2O DM0N9WA MN Calcitonin receptor (CALCR) DM0N9WA MT DTT DM0N9WA MA Modulator DM0N9WA RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. DM0N9WA RU https://www.fda.gov/ DM8ZVJ7 DI DM8ZVJ7 DM8ZVJ7 DN Calcitriol DM8ZVJ7 MI DE4LYSA DM8ZVJ7 MN Cytochrome P450 3A4 (CYP3A4) DM8ZVJ7 MT DME DM8ZVJ7 MA Metabolism DM8ZVJ7 RN Intestinal and hepatic CYP3A4 catalyze hydroxylation of 1alpha,25-dihydroxyvitamin D(3): implications for drug-induced osteomalacia. Mol Pharmacol. 2006 Jan;69(1):56-65. DM8ZVJ7 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=16207822 DM8ZVJ7 DI DM8ZVJ7 DM8ZVJ7 DN Calcitriol DM8ZVJ7 MI DELOY3P DM8ZVJ7 MN UDP-glucuronosyltransferase 1A4 (UGT1A4) DM8ZVJ7 MT DME DM8ZVJ7 MA Metabolism DM8ZVJ7 RN Identification of human UDP-glucuronosyltransferases catalyzing hepatic 1alpha,25-dihydroxyvitamin D3 conjugation. Biochem Pharmacol. 2008 Mar 1;75(5):1240-50. DM8ZVJ7 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=18177842 DM8ZVJ7 DI DM8ZVJ7 DM8ZVJ7 DN Calcitriol DM8ZVJ7 MI DEFI12S DM8ZVJ7 MN Vitamin D(3) 24-hydroxylase (CYP24A1) DM8ZVJ7 MT DME DM8ZVJ7 MA Metabolism DM8ZVJ7 RN The role of vitamin D in reducing cancer risk and progression. Nat Rev Cancer. 2014 May;14(5):342-57. DM8ZVJ7 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=24705652 DM8ZVJ7 DI DM8ZVJ7 DM8ZVJ7 DN Calcitriol DM8ZVJ7 MI TTK59TV DM8ZVJ7 MN Vitamin D3 receptor (VDR) DM8ZVJ7 MT DTT DM8ZVJ7 MA Agonist DM8ZVJ7 RN Kaposi sarcoma is a therapeutic target for vitamin D(3) receptor agonist. Blood. 2000 Nov 1;96(9):3188-94. DM8ZVJ7 RU https://pubmed.ncbi.nlm.nih.gov/11050002 DM3W15N DI DM3W15N DM3W15N DN Calcium carbimide DM3W15N MI TTCTAOJ DM3W15N MN Acetaldehyde dehydrogenase (ALDH) DM3W15N MT DTT DM3W15N MA Inhibitor DM3W15N RN Disulfiram and calcium carbimide. Mode of action, adverse effects and clinical use. Tidsskr Nor Laegeforen. 1990 Apr 10;110(10):1224-8. DM3W15N RU https://pubmed.ncbi.nlm.nih.gov/2185581 DM3W15N DI DM3W15N DM3W15N DN Calcium carbimide DM3W15N MI DE1XPGH DM3W15N MN Catalase (CAT) DM3W15N MT DME DM3W15N MA Metabolism DM3W15N RN Vasiliou V. and Petersen D. (2010). Comprehensive toxicology (2nd ed.). Elsevier. DM3W15N RU https://www.elsevier.com/books/comprehensive-toxicology/mcqueen/978-0-08-100601-6 DMJ3CFY DI DMJ3CFY DMJ3CFY DN Calcium phosphate dihydrate DMJ3CFY MI DTKS517 DMJ3CFY MN Sodium-dependent phosphate transport protein 2C (SLC34A3) DMJ3CFY MT DTP DMJ3CFY MA Substrate DMJ3CFY RN Phosphate transporters and their function. Annu Rev Physiol. 2013;75:535-50. DMJ3CFY RU http://www.ncbi.nlm.nih.gov/pubmed/23398154 DMWIO46 DI DMWIO46 DMWIO46 DN Camphor DMWIO46 MI DE9JBQK DMWIO46 MN Cytochrome P450 101D1 (cyp101) DMWIO46 MT DME DMWIO46 MA Metabolism DMWIO46 RN Patients with primary biliary cirrhosis react against a ubiquitous xenobiotic-metabolizing bacterium. Hepatology. 2003 Nov;38(5):1250-7. DMWIO46 RU https://pubmed.ncbi.nlm.nih.gov/14578864 DMWIO46 DI DMWIO46 DMWIO46 DN Camphor DMWIO46 MI DE7HL3C DMWIO46 MN Cytochrome P450 101D2 (cyp101) DMWIO46 MT DME DMWIO46 MA Metabolism DMWIO46 RN Patients with primary biliary cirrhosis react against a ubiquitous xenobiotic-metabolizing bacterium. Hepatology. 2003 Nov;38(5):1250-7. DMWIO46 RU https://pubmed.ncbi.nlm.nih.gov/14578864 DMWIO46 DI DMWIO46 DMWIO46 DN Camphor DMWIO46 MI DEJVYAZ DMWIO46 MN Cytochrome P450 2A6 (CYP2A6) DMWIO46 MT DME DMWIO46 MA Metabolism DMWIO46 RN In vitro metabolism of (-)-camphor using human liver microsomes and CYP2A6. Biol Pharm Bull. 2007 Feb;30(2):230-3. DMWIO46 RU https://pubmed.ncbi.nlm.nih.gov/17268056 DMFRM1I DI DMFRM1I DMFRM1I DN Canagliflozin DMFRM1I MI DTI7UX6 DMFRM1I MN Breast cancer resistance protein (ABCG2) DMFRM1I MT DTP DMFRM1I MA Substrate DMFRM1I RN In vitro and physiologically-based pharmacokinetic based assessment of drug-drug interaction potential of canagliflozin. Br J Clin Pharmacol. 2017 May;83(5):1082-1096. DMFRM1I RU http://www.ncbi.nlm.nih.gov/pubmed/27862160 DMFRM1I DI DMFRM1I DMFRM1I DN Canagliflozin DMFRM1I MI DE4LYSA DMFRM1I MN Cytochrome P450 3A4 (CYP3A4) DMFRM1I MT DME DMFRM1I MA Metabolism DMFRM1I RN Sodium-glucose linked transporter 2 (SGLT2) inhibitors in the management of type-2 diabetes: a drug class overview. P T. 2015 Jul;40(7):451-62. DMFRM1I RU https://www.ncbi.nlm.nih.gov/pubmed/?term=26185406 DMFRM1I DI DMFRM1I DMFRM1I DN Canagliflozin DMFRM1I MI DTUGYRD DMFRM1I MN P-glycoprotein 1 (ABCB1) DMFRM1I MT DTP DMFRM1I MA Substrate DMFRM1I RN In vitro and physiologically-based pharmacokinetic based assessment of drug-drug interaction potential of canagliflozin. Br J Clin Pharmacol. 2017 May;83(5):1082-1096. DMFRM1I RU http://www.ncbi.nlm.nih.gov/pubmed/27862160 DMFRM1I DI DMFRM1I DMFRM1I DN Canagliflozin DMFRM1I MI TTLWPVF DMFRM1I MN Sodium/glucose cotransporter 2 (SGLT2) DMFRM1I MT DTT DMFRM1I MA Modulator DMFRM1I RN Radium 223 dichloride for prostate cancer treatment. Drug Des Devel Ther. 2017 Sep 6;11:2643-2651. DMFRM1I RU https://pubmed.ncbi.nlm.nih.gov/28919714 DMFRM1I DI DMFRM1I DMFRM1I DN Canagliflozin DMFRM1I MI DE85D2P DMFRM1I MN UDP-glucuronosyltransferase 1A9 (UGT1A9) DMFRM1I MT DME DMFRM1I MA Metabolism DMFRM1I RN Effects of rifampin, cyclosporine A, and probenecid on the pharmacokinetic profile of canagliflozin, a sodium glucose co-transporter 2 inhibitor, in healthy participants. Int J Clin Pharmacol Ther. 2015 Feb;53(2):115-28. DMFRM1I RU https://www.ncbi.nlm.nih.gov/pubmed/?term=25407255 DMFRM1I DI DMFRM1I DMFRM1I DN Canagliflozin DMFRM1I MI DENUPDX DMFRM1I MN UDP-glucuronosyltransferase 2B4 (UGT2B4) DMFRM1I MT DME DMFRM1I MA Metabolism DMFRM1I RN Effects of rifampin, cyclosporine A, and probenecid on the pharmacokinetic profile of canagliflozin, a sodium glucose co-transporter 2 inhibitor, in healthy participants. Int J Clin Pharmacol Ther. 2015 Feb;53(2):115-28. DMFRM1I RU https://www.ncbi.nlm.nih.gov/pubmed/?term=25407255 DM8HLO5 DI DM8HLO5 DM8HLO5 DN Canakinumab DM8HLO5 MI TTRYK0X DM8HLO5 MN Interleukin-1 beta (IL1B) DM8HLO5 MT DTT DM8HLO5 RN Hughes B: 2009 FDA drug approvals. Nat Rev Drug Discov. 2010 Feb;9(2):89-92. DM8HLO5 RU https://pubmed.ncbi.nlm.nih.gov/20118952 DMRK8OT DI DMRK8OT DMRK8OT DN Candesartan DMRK8OT MI TT8DBY3 DMRK8OT MN Angiotensin II receptor type-1 (AGTR1) DMRK8OT MT DTT DMRK8OT MA Antagonist DMRK8OT RN Candesartan: widening indications for this angiotensin II receptor blocker Expert Opin Pharmacother. 2009 Aug;10(12):1995-2007. DMRK8OT RU https://pubmed.ncbi.nlm.nih.gov/19563275 DMRK8OT DI DMRK8OT DMRK8OT DN Candesartan DMRK8OT MI DEB30C5 DMRK8OT MN Carboxylesterase 1 (CES1) DMRK8OT MT DME DMRK8OT MA Metabolism DMRK8OT RN Different hydrolases involved in bioactivation of prodrug-type angiotensin receptor blockers: carboxymethylenebutenolidase and carboxylesterase 1. Drug Metab Dispos. 2013 Nov;41(11):1888-95. DMRK8OT RU https://www.ncbi.nlm.nih.gov/pubmed/?term=23946449 DMRK8OT DI DMRK8OT DMRK8OT DN Candesartan DMRK8OT MI DE5IED8 DMRK8OT MN Cytochrome P450 2C9 (CYP2C9) DMRK8OT MT DME DMRK8OT MA Metabolism DMRK8OT RN Product Monograph of Atacand. DMRK8OT RU https://www.astrazeneca.ca/content/dam/az-ca/downloads/productinformation/ATACAND%20-%20Product-Monograph_001.pdf DMRK8OT DI DMRK8OT DMRK8OT DN Candesartan DMRK8OT MI DE073H6 DMRK8OT MN Prostaglandin G/H synthase 1 (COX-1) DMRK8OT MT DME DMRK8OT MA Metabolism DMRK8OT RN Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. DMRK8OT RU https://www.ncbi.nlm.nih.gov/pubmed/?term=19515014 DMRK8OT DI DMRK8OT DMRK8OT DN Candesartan DMRK8OT MI DEYGVN4 DMRK8OT MN UDP-glucuronosyltransferase 1A1 (UGT1A1) DMRK8OT MT DME DMRK8OT MA Metabolism DMRK8OT RN The human UDP-glucuronosyltransferase UGT1A3 is highly selective towards N2 in the tetrazole ring of losartan, candesartan, and zolarsartan. Biochem Pharmacol. 2008 Sep 15;76(6):763-72. DMRK8OT RU https://www.ncbi.nlm.nih.gov/pubmed/?term=18674515 DMRK8OT DI DMRK8OT DMRK8OT DN Candesartan DMRK8OT MI DEF2WXN DMRK8OT MN UDP-glucuronosyltransferase 1A3 (UGT1A3) DMRK8OT MT DME DMRK8OT MA Metabolism DMRK8OT RN Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. DMRK8OT RU https://www.ncbi.nlm.nih.gov/pubmed/?term=19515014 DMNZSC1 DI DMNZSC1 DMNZSC1 DN Candicidin DMNZSC1 MI TTQKWA4 DMNZSC1 MN Fungal Cell membrane ergosterol (Fung CME) DMNZSC1 MT DTT DMNZSC1 MA Modulator DMNZSC1 RN Mode of Action of the Polyene Antibiotic Candicidin: Binding Factors in the Wall of Candida albicans DMNZSC1 RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC429577 DM8JRH0 DI DM8JRH0 DM8JRH0 DN Cangrelor DM8JRH0 MI TTZ1DT0 DM8JRH0 MN P2Y purinoceptor 12 (P2RY12) DM8JRH0 MT DTT DM8JRH0 MA Antagonist DM8JRH0 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 328). DM8JRH0 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=328 DM0659E DI DM0659E DM0659E DN Cannabidiol DM0659E MI TT94IAG DM0659E MN Cannabinoid receptor (CB) DM0659E MT DTT DM0659E MA Binder DM0659E RN (-)-Cannabidiol antagonizes cannabinoid receptor agonists and noradrenaline in the mouse vas deferens. Eur J Pharmacol. 2002 Dec 5;456(1-3):99-106. DM0659E RU https://pubmed.ncbi.nlm.nih.gov/12450575 DM0659E DI DM0659E DM0659E DN Cannabidiol DM0659E MI DE5IED8 DM0659E MN Cytochrome P450 2C9 (CYP2C9) DM0659E MT DME DM0659E MA Metabolism DM0659E RN Molecular targets of cannabidiol in neurological disorders. Neurotherapeutics. 2015 Oct;12(4):699-730. DM0659E RU https://www.ncbi.nlm.nih.gov/pubmed/?term=26264914 DM0659E DI DM0659E DM0659E DN Cannabidiol DM0659E MI DECB0K3 DM0659E MN Cytochrome P450 2D6 (CYP2D6) DM0659E MT DME DM0659E MA Metabolism DM0659E RN Exogenous cannabinoids as substrates, inhibitors, and inducers of human drug metabolizing enzymes: a systematic review. Drug Metab Rev. 2014 Feb;46(1):86-95. DM0659E RU https://www.ncbi.nlm.nih.gov/pubmed/?term=24160757 DM0659E DI DM0659E DM0659E DN Cannabidiol DM0659E MI DE4LYSA DM0659E MN Cytochrome P450 3A4 (CYP3A4) DM0659E MT DME DM0659E MA Metabolism DM0659E RN Molecular targets of cannabidiol in neurological disorders. Neurotherapeutics. 2015 Oct;12(4):699-730. DM0659E RU https://www.ncbi.nlm.nih.gov/pubmed/?term=26264914 DM0659E DI DM0659E DM0659E DN Cannabidiol DM0659E MI DEIBDNY DM0659E MN Cytochrome P450 3A5 (CYP3A5) DM0659E MT DME DM0659E MA Metabolism DM0659E RN Exogenous cannabinoids as substrates, inhibitors, and inducers of human drug metabolizing enzymes: a systematic review. Drug Metab Rev. 2014 Feb;46(1):86-95. DM0659E RU https://www.ncbi.nlm.nih.gov/pubmed/?term=24160757 DM0659E DI DM0659E DM0659E DN Cannabidiol DM0659E MI DEGTFWK DM0659E MN Mephenytoin 4-hydroxylase (CYP2C19) DM0659E MT DME DM0659E MA Metabolism DM0659E RN Molecular targets of cannabidiol in neurological disorders. Neurotherapeutics. 2015 Oct;12(4):699-730. DM0659E RU https://www.ncbi.nlm.nih.gov/pubmed/?term=26264914 DM0659E DI DM0659E DM0659E DN Cannabidiol DM0659E MI DTUGYRD DM0659E MN P-glycoprotein 1 (ABCB1) DM0659E MT DTP DM0659E MA Substrate DM0659E RN KEGG: new perspectives on genomes, pathways, diseases and drugs. Nucleic Acids Res. 2017 Jan 4;45(D1):D353-D361. (dg:DG01665) DM0659E RU https://www.kegg.jp/dbget-bin/www_bget?dg:DG01665 DMBP5N3 DI DMBP5N3 DMBP5N3 DN Cantharidin DMBP5N3 MI TTFLH0E DMBP5N3 MN Serine/threonine PP1-alpha (PPP1CA) DMBP5N3 MT DTT DMBP5N3 MA Inhibitor DMBP5N3 RN Serine-threonine protein phosphatase inhibitors: development of potential therapeutic strategies. J Med Chem. 2002 Mar 14;45(6):1151-75. DMBP5N3 RU https://pubmed.ncbi.nlm.nih.gov/11881984 DMTS85L DI DMTS85L DMTS85L DN Capecitabine DMTS85L MI TTU6BFZ DMTS85L MN Candida Thymidylate synthase (Candi TMP1) DMTS85L MT DTT DMTS85L MA Inhibitor DMTS85L RN UGT1A7 and UGT1A9 polymorphisms predict response and toxicity in colorectal cancer patients treated with capecitabine/irinotecan. Clin Cancer Res. 2005 Feb 1;11(3):1226-36. DMTS85L RU https://pubmed.ncbi.nlm.nih.gov/15709193 DMTS85L DI DMTS85L DMTS85L DN Capecitabine DMTS85L MI DEKEDRC DMTS85L MN Cytidine aminohydrolase (CDA) DMTS85L MT DME DMTS85L MA Metabolism DMTS85L RN Augmentation of the antitumor activity of capecitabine by a tumor selective dihydropyrimidine dehydrogenase inhibitor, RO0094889. Int J Cancer. 2003 Sep 20;106(5):799-805. DMTS85L RU https://www.ncbi.nlm.nih.gov/pubmed/?term=12866042 DMTS85L DI DMTS85L DMTS85L DN Capecitabine DMTS85L MI DE4HCYL DMTS85L MN Thymidine phosphorylase (TYMP) DMTS85L MT DME DMTS85L MA Metabolism DMTS85L RN Induction of thymidine phosphorylase in both irradiated and shielded, contralateral human U87MG glioma xenografts: implications for a dual modality treatment using capecitabine and irradiation. Mol Cancer Ther. 2002 Oct;1(12):1139-45. DMTS85L RU https://www.ncbi.nlm.nih.gov/pubmed/?term=12481438 DMPUKA7 DI DMPUKA7 DMPUKA7 DN Caplacizumab DMPUKA7 MI TT3SZBT DMPUKA7 MN von Willebrand factor (VWF) DMPUKA7 MT DTT DMPUKA7 MA Inhibitor DMPUKA7 RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health Human Services. 2019 DMPUKA7 RU https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/761112s000lbl.pdf DMYCXKL DI DMYCXKL DMYCXKL DN Capmatinib DMYCXKL MI TTNDSF4 DMYCXKL MN Proto-oncogene c-Met (MET) DMYCXKL MT DTT DMYCXKL MA Modulator DMYCXKL RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health Human Services. 2020 DMYCXKL RU https://www.accessdata.fda.gov/drugsatfda_docs/label/2020/213591s000lbl.pdf DMNZBRY DI DMNZBRY DMNZBRY DN Capreomycin DMNZBRY MI TTIA0J5 DMNZBRY MN Bacterial 70S ribosomal RNA (Bact 70S rRNA) DMNZBRY MT DTT DMNZBRY MA Binder DMNZBRY RN Interaction between the ribosomal subunits: 16S rRNA suppressors of the lethal DeltaA1916 mutation in the 23S rRNA of Escherichia coli. Mol Genet Genomics. 2007 Sep;278(3):307-15. DMNZBRY RU https://pubmed.ncbi.nlm.nih.gov/17564727 DM346QI DI DM346QI DM346QI DN Capreomycin Sulfate DM346QI MI TTIA0J5 DM346QI MN Bacterial 70S ribosomal RNA (Bact 70S rRNA) DM346QI MT DTT DM346QI MA Modulator DM346QI RN The structures of the anti-tuberculosis antibiotics viomycin and capreomycin bound to the 70S ribosome.Nat Struct Mol Biol.2010 Mar;17(3):289-93. DM346QI RU https://www.ncbi.nlm.nih.gov/pubmed/20154709 DMHERIJ DI DMHERIJ DMHERIJ DN Capromab DMHERIJ MI TT9G4N0 DMHERIJ MN Glutamate carboxypeptidase II (GCPII) DMHERIJ MT DTT DMHERIJ RN Synergistic value of single-photon emission computed tomography/computed tomography fusion to radioimmunoscintigraphic imaging of prostate cancer. Semin Nucl Med. 2007 Jan;37(1):17-28. DMHERIJ RU https://pubmed.ncbi.nlm.nih.gov/17161036 DMGMF6V DI DMGMF6V DMGMF6V DN Capsaicin DMGMF6V MI DE6OQ3W DMGMF6V MN Cytochrome P450 1A1 (CYP1A1) DMGMF6V MT DME DMGMF6V MA Metabolism DMGMF6V RN Metabolism of capsaicin by cytochrome P450 produces novel dehydrogenated metabolites and decreases cytotoxicity to lung and liver cells. Chem Res Toxicol. 2003 Mar;16(3):336-49. DMGMF6V RU https://www.ncbi.nlm.nih.gov/pubmed/?term=12641434 DMGMF6V DI DMGMF6V DMGMF6V DN Capsaicin DMGMF6V MI DEJGDUW DMGMF6V MN Cytochrome P450 1A2 (CYP1A2) DMGMF6V MT DME DMGMF6V MA Metabolism DMGMF6V RN Metabolism of capsaicin by cytochrome P450 produces novel dehydrogenated metabolites and decreases cytotoxicity to lung and liver cells. Chem Res Toxicol. 2003 Mar;16(3):336-49. DMGMF6V RU https://www.ncbi.nlm.nih.gov/pubmed/?term=12641434 DMGMF6V DI DMGMF6V DMGMF6V DN Capsaicin DMGMF6V MI DEPKLMQ DMGMF6V MN Cytochrome P450 2B6 (CYP2B6) DMGMF6V MT DME DMGMF6V MA Metabolism DMGMF6V RN Metabolism of capsaicin by cytochrome P450 produces novel dehydrogenated metabolites and decreases cytotoxicity to lung and liver cells. Chem Res Toxicol. 2003 Mar;16(3):336-49. DMGMF6V RU https://www.ncbi.nlm.nih.gov/pubmed/?term=12641434 DMGMF6V DI DMGMF6V DMGMF6V DN Capsaicin DMGMF6V MI DES5XRU DMGMF6V MN Cytochrome P450 2C8 (CYP2C8) DMGMF6V MT DME DMGMF6V MA Metabolism DMGMF6V RN Metabolism of capsaicin by cytochrome P450 produces novel dehydrogenated metabolites and decreases cytotoxicity to lung and liver cells. Chem Res Toxicol. 2003 Mar;16(3):336-49. DMGMF6V RU https://www.ncbi.nlm.nih.gov/pubmed/?term=12641434 DMGMF6V DI DMGMF6V DMGMF6V DN Capsaicin DMGMF6V MI DE5IED8 DMGMF6V MN Cytochrome P450 2C9 (CYP2C9) DMGMF6V MT DME DMGMF6V MA Metabolism DMGMF6V RN Metabolism of capsaicin by cytochrome P450 produces novel dehydrogenated metabolites and decreases cytotoxicity to lung and liver cells. Chem Res Toxicol. 2003 Mar;16(3):336-49. DMGMF6V RU https://www.ncbi.nlm.nih.gov/pubmed/?term=12641434 DMGMF6V DI DMGMF6V DMGMF6V DN Capsaicin DMGMF6V MI DECB0K3 DMGMF6V MN Cytochrome P450 2D6 (CYP2D6) DMGMF6V MT DME DMGMF6V MA Metabolism DMGMF6V RN Metabolism of capsaicin by cytochrome P450 produces novel dehydrogenated metabolites and decreases cytotoxicity to lung and liver cells. Chem Res Toxicol. 2003 Mar;16(3):336-49. DMGMF6V RU https://www.ncbi.nlm.nih.gov/pubmed/?term=12641434 DMGMF6V DI DMGMF6V DMGMF6V DN Capsaicin DMGMF6V MI DEVDYN7 DMGMF6V MN Cytochrome P450 2E1 (CYP2E1) DMGMF6V MT DME DMGMF6V MA Metabolism DMGMF6V RN Metabolism of capsaicin by cytochrome P450 produces novel dehydrogenated metabolites and decreases cytotoxicity to lung and liver cells. Chem Res Toxicol. 2003 Mar;16(3):336-49. DMGMF6V RU https://www.ncbi.nlm.nih.gov/pubmed/?term=12641434 DMGMF6V DI DMGMF6V DMGMF6V DN Capsaicin DMGMF6V MI DE4LYSA DMGMF6V MN Cytochrome P450 3A4 (CYP3A4) DMGMF6V MT DME DMGMF6V MA Metabolism DMGMF6V RN Metabolism of capsaicin by cytochrome P450 produces novel dehydrogenated metabolites and decreases cytotoxicity to lung and liver cells. Chem Res Toxicol. 2003 Mar;16(3):336-49. DMGMF6V RU https://www.ncbi.nlm.nih.gov/pubmed/?term=12641434 DMGMF6V DI DMGMF6V DMGMF6V DN Capsaicin DMGMF6V MI DEGTFWK DMGMF6V MN Mephenytoin 4-hydroxylase (CYP2C19) DMGMF6V MT DME DMGMF6V MA Metabolism DMGMF6V RN Metabolism of capsaicin by cytochrome P450 produces novel dehydrogenated metabolites and decreases cytotoxicity to lung and liver cells. Chem Res Toxicol. 2003 Mar;16(3):336-49. 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DM458UM RU https://www.ncbi.nlm.nih.gov/pubmed/?term=6344869 DMX9K8F DI DMX9K8F DMX9K8F DN Carbachol DMX9K8F MI TTF4E0J DMX9K8F MN Neuronal acetylcholine receptor alpha-2 (CHRNA2) DMX9K8F MT DTT DMX9K8F MA Antagonist DMX9K8F RN Synergy between pairs of competitive antagonists at adult human muscle acetylcholine receptors. Anesth Analg. 2008 Aug;107(2):525-33. DMX9K8F RU https://pubmed.ncbi.nlm.nih.gov/18633030 DMZOLBI DI DMZOLBI DMZOLBI DN Carbamazepine DMZOLBI MI DEJGDUW DMZOLBI MN Cytochrome P450 1A2 (CYP1A2) DMZOLBI MT DME DMZOLBI MA Metabolism DMZOLBI RN Interactions between antiepileptics and second-generation antipsychotics. Expert Opin Drug Metab Toxicol. 2012 Mar;8(3):311-34. DMZOLBI RU https://www.ncbi.nlm.nih.gov/pubmed/?term=22332980 DMZOLBI DI DMZOLBI DMZOLBI DN Carbamazepine DMZOLBI MI DEPKLMQ DMZOLBI MN Cytochrome P450 2B6 (CYP2B6) DMZOLBI MT DME DMZOLBI MA Metabolism DMZOLBI RN Regulation of CYP2B6 in primary human hepatocytes by prototypical inducers. Drug Metab Dispos. 2004 Mar;32(3):348-58. DMZOLBI RU https://www.ncbi.nlm.nih.gov/pubmed/?term=14977870 DMZOLBI DI DMZOLBI DMZOLBI DN Carbamazepine DMZOLBI MI DES5XRU DMZOLBI MN Cytochrome P450 2C8 (CYP2C8) DMZOLBI MT DME DMZOLBI MA Metabolism DMZOLBI RN Potential interaction between ritonavir and carbamazepine. Pharmacotherapy. 2000 Jul;20(7):851-4. DMZOLBI RU https://www.ncbi.nlm.nih.gov/pubmed/?term=10907977 DMZOLBI DI DMZOLBI DMZOLBI DN Carbamazepine DMZOLBI MI DE4LYSA DMZOLBI MN Cytochrome P450 3A4 (CYP3A4) DMZOLBI MT DME DMZOLBI MA Metabolism DMZOLBI RN Carbamazepine pharmacokinetics are not affected by zonisamide: in vitro mechanistic study and in vivo clinical study in epileptic patients. Epilepsy Res. 2004 Nov;62(1):1-11. DMZOLBI RU https://www.ncbi.nlm.nih.gov/pubmed/?term=15519127 DMZOLBI DI DMZOLBI DMZOLBI DN Carbamazepine DMZOLBI MI DEIBDNY DMZOLBI MN Cytochrome P450 3A5 (CYP3A5) DMZOLBI MT DME DMZOLBI MA Metabolism DMZOLBI RN Induction of CYP3As in HepG2 cells by several drugs. Association between induction of CYP3A4 and expression of glucocorticoid receptor. Biol Pharm Bull. 2003 Apr;26(4):510-7. DMZOLBI RU https://www.ncbi.nlm.nih.gov/pubmed/?term=12673034 DMZOLBI DI DMZOLBI DMZOLBI DN Carbamazepine DMZOLBI MI DERD86B DMZOLBI MN Cytochrome P450 3A7 (CYP3A7) DMZOLBI MT DME DMZOLBI MA Metabolism DMZOLBI RN CYP3A4 and CYP3A7-mediated carbamazepine 10,11-epoxidation are activated by differential endogenous steroids. Drug Metab Dispos. 2003 Apr;31(4):432-8. 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DMLEDNK RU https://pubmed.ncbi.nlm.nih.gov/977998 DMLEDNK DI DMLEDNK DMLEDNK DN Carbenicillin DMLEDNK MI DEIU0XN DMLEDNK MN N-acylhomoserine lactone acylase (lacA) DMLEDNK MT DME DMLEDNK MA Metabolism DMLEDNK RN A novel quorum-quenching N-acylhomoserine lactone acylase from Acidovorax sp. strain MR-S7 mediates antibiotic resistance. Appl Environ Microbiol. 2017 Jun 16;83(13). pii: e00080-17. DMLEDNK RU https://pubmed.ncbi.nlm.nih.gov/28455333 DMLEDNK DI DMLEDNK DMLEDNK DN Carbenicillin DMLEDNK MI DE2ARDZ DMLEDNK MN PenA beta-lactamase (penA1) DMLEDNK MT DME DMLEDNK MA Metabolism DMLEDNK RN Characterization of the penA and penR genes of Burkholderia cepacia 249 which encode the chromosomal class A penicillinase and its LysR-type transcriptional regulator. Antimicrob Agents Chemother. 1997 Nov;41(11):2399-405. DMLEDNK RU https://pubmed.ncbi.nlm.nih.gov/9371340 DME2XG3 DI DME2XG3 DME2XG3 DN Carbenicillin Indanyl Sodium DME2XG3 MI TTJP4SM DME2XG3 MN Bacterial Penicillin binding protein (Bact PBP) DME2XG3 MT DTT DME2XG3 MA Modulator DME2XG3 RN Carbenicillin resistance of Pseudomonas aeruginosa. Antimicrob Agents Chemother. 1982 Aug;22(2):255-61. DME2XG3 RU https://www.ncbi.nlm.nih.gov/pubmed/6821456 DMUSLW3 DI DMUSLW3 DMUSLW3 DN Carbetocin DMUSLW3 MI TTSCIUP DMUSLW3 MN Oxytocin receptor (OTR) DMUSLW3 MT DTT DMUSLW3 MA Agonist DMUSLW3 RN Peptide and non-peptide agonists and antagonists for the vasopressin and oxytocin V1a, V1b, V2 and OT receptors: research tools and potential therapeutic agents. Prog Brain Res. 2008;170:473-512. 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Naunyn Schmiedebergs Arch Pharmacol. 1994 Feb;349(2):140-4. DMCT31R RU https://pubmed.ncbi.nlm.nih.gov/7513381 DMG281S DI DMG281S DMG281S DN Carboplatin DMG281S MI DEYZEJA DMG281S MN Glutathione S-transferase mu-1 (GSTM1) DMG281S MT DME DMG281S MA Metabolism DMG281S RN PharmGKB: A worldwide resource for pharmacogenomic information. Wiley Interdiscip Rev Syst Biol Med. 2018 Jul;10(4):e1417. (ID: PA150642262) DMG281S RU https://www.pharmgkb.org/pathway/PA150642262 DMG281S DI DMG281S DMG281S DN Carboplatin DMG281S MI DEK6079 DMG281S MN Glutathione S-transferase pi (GSTP1) DMG281S MT DME DMG281S MA Metabolism DMG281S RN PharmGKB: A worldwide resource for pharmacogenomic information. Wiley Interdiscip Rev Syst Biol Med. 2018 Jul;10(4):e1417. (ID: PA150642262) DMG281S RU https://www.pharmgkb.org/pathway/PA150642262 DMG281S DI DMG281S DMG281S DN Carboplatin DMG281S MI DE3PKUG DMG281S MN Glutathione S-transferase theta-1 (GSTT1) DMG281S MT DME DMG281S MA Metabolism DMG281S RN PharmGKB: A worldwide resource for pharmacogenomic information. Wiley Interdiscip Rev Syst Biol Med. 2018 Jul;10(4):e1417. (ID: PA150642262) DMG281S RU https://www.pharmgkb.org/pathway/PA150642262 DMG281S DI DMG281S DMG281S DN Carboplatin DMG281S MI DTP8L4F DMG281S MN High affinity copper uptake protein 1 (SLC31A1) DMG281S MT DTP DMG281S MA Substrate DMG281S RN Overcoming platinum drug resistance with copper-lowering agents. Anticancer Res. 2013 Oct;33(10):4157-61. DMG281S RU http://www.ncbi.nlm.nih.gov/pubmed/24122978 DMG281S DI DMG281S DMG281S DN Carboplatin DMG281S MI TTUTN1I DMG281S MN Human Deoxyribonucleic acid (hDNA) DMG281S MT DTT DMG281S MA Modulator DMG281S RN Inhibition of carboplatin-induced DNA interstrand cross-link repair by gemcitabine in patients receiving these drugs for platinum-resistant ovarian cancer.Clin Cancer Res.2010 Oct 1;16(19):4899-905. DMG281S RU https://www.ncbi.nlm.nih.gov/pubmed/20719935 DMG281S DI DMG281S DMG281S DN Carboplatin DMG281S MI DE5ME8A DMG281S MN Metallothionein-1A (MT1A) DMG281S MT DME DMG281S MA Metabolism DMG281S RN PharmGKB: A worldwide resource for pharmacogenomic information. Wiley Interdiscip Rev Syst Biol Med. 2018 Jul;10(4):e1417. (ID: PA150642262) DMG281S RU https://www.pharmgkb.org/pathway/PA150642262 DMG281S DI DMG281S DMG281S DN Carboplatin DMG281S MI DEFKGT7 DMG281S MN Metallothionein-2A (MT2A) DMG281S MT DME DMG281S MA Metabolism DMG281S RN PharmGKB: A worldwide resource for pharmacogenomic information. Wiley Interdiscip Rev Syst Biol Med. 2018 Jul;10(4):e1417. (ID: PA150642262) DMG281S RU https://www.pharmgkb.org/pathway/PA150642262 DMG281S DI DMG281S DMG281S DN Carboplatin DMG281S MI DEA3U9Y DMG281S MN Myeloperoxidase (MPO) DMG281S MT DME DMG281S MA Metabolism DMG281S RN PharmGKB: A worldwide resource for pharmacogenomic information. Wiley Interdiscip Rev Syst Biol Med. 2018 Jul;10(4):e1417. (ID: PA150642262) DMG281S RU https://www.pharmgkb.org/pathway/PA150642262 DMG281S DI DMG281S DMG281S DN Carboplatin DMG281S MI DENP5RY DMG281S MN Quinone reductase 1 (NQO1) DMG281S MT DME DMG281S MA Metabolism DMG281S RN PharmGKB: A worldwide resource for pharmacogenomic information. Wiley Interdiscip Rev Syst Biol Med. 2018 Jul;10(4):e1417. (ID: PA150642262) DMG281S RU https://www.pharmgkb.org/pathway/PA150642262 DMS3508 DI DMS3508 DMS3508 DN Carboprost tromethamine DMS3508 MI TTT2ZAR DMS3508 MN Prostaglandin F2-alpha receptor (PTGFR) DMS3508 MT DTT DMS3508 MA Modulator DMS3508 RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. DMS3508 RU https://www.fda.gov/ DM48K0X DI DM48K0X DM48K0X DN Carfilzomib DM48K0X MI DTUGYRD DM48K0X MN P-glycoprotein 1 (ABCB1) DM48K0X MT DTP DM48K0X MA Substrate DM48K0X RN Identification of an ABCB1 (P-glycoprotein)-positive carfilzomib-resistant myeloma subpopulation by the pluripotent stem cell fluorescent dye CDy1. Am J Hematol. 2013 Apr;88(4):265-72. DM48K0X RU http://www.ncbi.nlm.nih.gov/pubmed/23475625 DM48K0X DI DM48K0X DM48K0X DN Carfilzomib DM48K0X MI TTU7ZMG DM48K0X MN Proteasome (PS) DM48K0X MT DTT DM48K0X MA Modulator DM48K0X RN Nat Rev Drug Discov. 2013 Feb;12(2):87-90. DM48K0X RU https://pubmed.ncbi.nlm.nih.gov/23370234 DMCY0TI DI DMCY0TI DMCY0TI DN Carglumic acid DMCY0TI MI TT42M75 DMCY0TI MN Carbamoyl-phosphate synthetase I (CPS1) DMCY0TI MT DTT DMCY0TI MA Activator DMCY0TI RN Mullard A: 2010 FDA drug approvals. Nat Rev Drug Discov. 2011 Feb;10(2):82-5. DMCY0TI RU https://pubmed.ncbi.nlm.nih.gov/21283092 DMJYDVK DI DMJYDVK DMJYDVK DN Cariprazine DMJYDVK MI DECB0K3 DMJYDVK MN Cytochrome P450 2D6 (CYP2D6) DMJYDVK MT DME DMJYDVK MA Metabolism DMJYDVK RN Cariprazine: chemistry, pharmacodynamics, pharmacokinetics, and metabolism, clinical efficacy, safety, and tolerability. Expert Opin Drug Metab Toxicol. 2013 Feb;9(2):193-206. DMJYDVK RU https://www.ncbi.nlm.nih.gov/pubmed/?term=23320989 DMJYDVK DI DMJYDVK DMJYDVK DN Cariprazine DMJYDVK MI DE4LYSA DMJYDVK MN Cytochrome P450 3A4 (CYP3A4) DMJYDVK MT DME DMJYDVK MA Metabolism DMJYDVK RN Cariprazine: chemistry, pharmacodynamics, pharmacokinetics, and metabolism, clinical efficacy, safety, and tolerability. Expert Opin Drug Metab Toxicol. 2013 Feb;9(2):193-206. DMJYDVK RU https://www.ncbi.nlm.nih.gov/pubmed/?term=23320989 DMJYDVK DI DMJYDVK DMJYDVK DN Cariprazine DMJYDVK MI TTEX248 DMJYDVK MN Dopamine D2 receptor (D2R) DMJYDVK MT DTT DMJYDVK MA Modulator DMJYDVK RN Radium 223 dichloride for prostate cancer treatment. Drug Des Devel Ther. 2017 Sep 6;11:2643-2651. DMJYDVK RU https://pubmed.ncbi.nlm.nih.gov/28919714 DMJYDVK DI DMJYDVK DMJYDVK DN Cariprazine DMJYDVK MI TT4C8EA DMJYDVK MN Dopamine D3 receptor (D3R) DMJYDVK MT DTT DMJYDVK MA Modulator DMJYDVK RN Radium 223 dichloride for prostate cancer treatment. Drug Des Devel Ther. 2017 Sep 6;11:2643-2651. DMJYDVK RU https://pubmed.ncbi.nlm.nih.gov/28919714 DMWR1JC DI DMWR1JC DMWR1JC DN Carisoprodol DMWR1JC MI DEGTFWK DMWR1JC MN Mephenytoin 4-hydroxylase (CYP2C19) DMWR1JC MT DME DMWR1JC MA Metabolism DMWR1JC RN Association between blood carisoprodol:meprobamate concentration ratios and CYP2C19 genotype in carisoprodol-drugged drivers: decreased metabolic capacity in heterozygous CYP2C19*1/CYP2C19*2 subjects? Pharmacogenetics. 2003 Jul;13(7):383-8. DMWR1JC RU https://www.ncbi.nlm.nih.gov/pubmed/?term=12835613 DMHTB31 DI DMHTB31 DMHTB31 DN Carphenazine DMHTB31 MI TTEX248 DMHTB31 MN Dopamine D2 receptor (D2R) DMHTB31 MT DTT DMHTB31 MA Antagonist DMHTB31 RN Atypical antipsychotics: mechanism of action. Can J Psychiatry. 2002 Feb;47(1):27-38. DMHTB31 RU https://pubmed.ncbi.nlm.nih.gov/11873706 DMHMP05 DI DMHMP05 DMHMP05 DN Carprofen DMHMP05 MI TTVKILB DMHMP05 MN Prostaglandin G/H synthase 2 (COX-2) DMHMP05 MT DTT DMHMP05 MA Inhibitor DMHMP05 RN Scaffold of the cyclooxygenase-2 (COX-2) inhibitor carprofen provides Alzheimer gamma-secretase modulators. J Med Chem. 2006 Dec 28;49(26):7588-91. DMHMP05 RU https://pubmed.ncbi.nlm.nih.gov/17181139 DMHMP05 DI DMHMP05 DMHMP05 DN Carprofen DMHMP05 MI DEB3CV1 DMHMP05 MN UDP-glucuronosyltransferase 2B7 (UGT2B7) DMHMP05 MT DME DMHMP05 MA Metabolism DMHMP05 RN Enantioselective inhibition of carprofen towards UDP-glucuronosyltransferase (UGT) 2B7. Chirality. 2015 Mar;27(3):189-93. DMHMP05 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=25502512 DMFMDOB DI DMFMDOB DMFMDOB DN Carteolol DMFMDOB MI TTR6W5O DMFMDOB MN Adrenergic receptor beta-1 (ADRB1) DMFMDOB MT DTT DMFMDOB MA Agonist DMFMDOB RN Partial agonistic effects of carteolol on atypical beta-adrenoceptors in the guinea pig gastric fundus. Jpn J Pharmacol. 2000 Nov;84(3):287-92. DMFMDOB RU https://pubmed.ncbi.nlm.nih.gov/11138729 DMFMDOB DI DMFMDOB DMFMDOB DN Carteolol DMFMDOB MI DECB0K3 DMFMDOB MN Cytochrome P450 2D6 (CYP2D6) DMFMDOB MT DME DMFMDOB MA Metabolism DMFMDOB RN Involvement of CYP2D1 in the metabolism of carteolol by male rat liver microsomes. Xenobiotica. 1997 Nov;27(11):1121-9. DMFMDOB RU https://www.ncbi.nlm.nih.gov/pubmed/?term=9413916 DMHTEAO DI DMHTEAO DMHTEAO DN Carvedilol DMHTEAO MI TTG28O6 DMHTEAO MN Adrenergic receptor Alpha-1 (ADRA1) DMHTEAO MT DTT DMHTEAO MA Antagonist DMHTEAO RN Beta-blockers in the treatment of hypertension: are there clinically relevant differences Postgrad Med. 2009 May;121(3):90-8. DMHTEAO RU https://pubmed.ncbi.nlm.nih.gov/19491545 DMHTEAO DI DMHTEAO DMHTEAO DN Carvedilol DMHTEAO MI DEJGDUW DMHTEAO MN Cytochrome P450 1A2 (CYP1A2) DMHTEAO MT DME DMHTEAO MA Metabolism DMHTEAO RN Pharmacokinetic interactions study between carvedilol and some antidepressants in rat liver microsomes - a comparative study. Med Pharm Rep. 2019 Apr;92(2):158-164. DMHTEAO RU https://www.ncbi.nlm.nih.gov/pubmed/?term=31086844 DMHTEAO DI DMHTEAO DMHTEAO DN Carvedilol DMHTEAO MI DE5IED8 DMHTEAO MN Cytochrome P450 2C9 (CYP2C9) DMHTEAO MT DME DMHTEAO MA Metabolism DMHTEAO RN The role of CYP2C9 genetic polymorphism in carvedilol O-desmethylation in vitro. Eur J Drug Metab Pharmacokinet. 2016 Feb;41(1):79-86. DMHTEAO RU https://www.ncbi.nlm.nih.gov/pubmed/?term=25476996 DMHTEAO DI DMHTEAO DMHTEAO DN Carvedilol DMHTEAO MI DECB0K3 DMHTEAO MN Cytochrome P450 2D6 (CYP2D6) DMHTEAO MT DME DMHTEAO MA Metabolism DMHTEAO RN Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. DMHTEAO RU https://www.ncbi.nlm.nih.gov/pubmed/?term=19515014 DMHTEAO DI DMHTEAO DMHTEAO DN Carvedilol DMHTEAO MI DEVDYN7 DMHTEAO MN Cytochrome P450 2E1 (CYP2E1) DMHTEAO MT DME DMHTEAO MA Metabolism DMHTEAO RN In vitro identification of the human cytochrome P450 enzymes involved in the metabolism of R(+)- and S(-)-carvedilol. Drug Metab Dispos. 1997 Aug;25(8):970-7. DMHTEAO RU https://www.ncbi.nlm.nih.gov/pubmed/?term=9280405 DMHTEAO DI DMHTEAO DMHTEAO DN Carvedilol DMHTEAO MI DE4LYSA DMHTEAO MN Cytochrome P450 3A4 (CYP3A4) DMHTEAO MT DME DMHTEAO MA Metabolism DMHTEAO RN Role of cytochrome P450 2D6 genetic polymorphism in carvedilol hydroxylation in vitro. Drug Des Devel Ther. 2016 Jun 8;10:1909-16. DMHTEAO RU https://www.ncbi.nlm.nih.gov/pubmed/?term=27354764 DMHTEAO DI DMHTEAO DMHTEAO DN Carvedilol DMHTEAO MI DTUGYRD DMHTEAO MN P-glycoprotein 1 (ABCB1) DMHTEAO MT DTP DMHTEAO MA Substrate DMHTEAO RN Tarascon Pocket Pharmacopoeia 2018 Classic Shirt-Pocket Edition. DMHTEAO RU https://books.google.com/books?id=0gBRDwAAQBAJ&pg=PP37&lpg=PP37&dq=Methylergonovine+transporter+uptake+efflex&source=bl&ots=cUTe_ppsmZ&sig=ACfU3U3E_YqrDg0CNEuj8K-7lci47HAnrg&hl=zh-CN&sa=X&ved=2ahUKEwjnj-Dk7d7iAhUsK6YKHd5DBDkQ6AEwEnoECAgQAQ#v=onepage&q&f=false DMHTEAO DI DMHTEAO DMHTEAO DN Carvedilol DMHTEAO MI DEYGVN4 DMHTEAO MN UDP-glucuronosyltransferase 1A1 (UGT1A1) DMHTEAO MT DME DMHTEAO MA Metabolism DMHTEAO RN Drug-drug interactions for UDP-glucuronosyltransferase substrates: a pharmacokinetic explanation for typically observed low exposure (AUCi/AUC) ratios. Drug Metab Dispos. 2004 Nov;32(11):1201-8. DMHTEAO RU https://www.ncbi.nlm.nih.gov/pubmed/?term=15304429 DMHTEAO DI DMHTEAO DMHTEAO DN Carvedilol DMHTEAO MI DEB3CV1 DMHTEAO MN UDP-glucuronosyltransferase 2B7 (UGT2B7) DMHTEAO MT DME DMHTEAO MA Metabolism DMHTEAO RN Drug-drug interactions for UDP-glucuronosyltransferase substrates: a pharmacokinetic explanation for typically observed low exposure (AUCi/AUC) ratios. Drug Metab Dispos. 2004 Nov;32(11):1201-8. DMHTEAO RU https://www.ncbi.nlm.nih.gov/pubmed/?term=15304429 DMZPXRC DI DMZPXRC DMZPXRC DN Carzinophilin DMZPXRC MI TTY1GPO DMZPXRC MN Human Deoxyribonucleic acid major groove (hDNA maj) DMZPXRC MT DTT DMZPXRC MA Modulator DMZPXRC RN Natural products as sources of new drugs over the last 25 years. J Nat Prod. 2007 Mar;70(3):461-77. DMZPXRC RU https://pubmed.ncbi.nlm.nih.gov/17309302 DMGQIPT DI DMGQIPT DMGQIPT DN Caspofungin DMGQIPT MI TT0SFXH DMGQIPT MN Fungal 1,3-beta-glucan synthase (Fung GSC2) DMGQIPT MT DTT DMGQIPT MA Modulator DMGQIPT RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. DMGQIPT RU https://www.fda.gov/ DMGQIPT DI DMGQIPT DMGQIPT DN Caspofungin DMGQIPT MI DT3D8F0 DMGQIPT MN Organic anion transporting polypeptide 1B1 (SLCO1B1) DMGQIPT MT DTP DMGQIPT MA Substrate DMGQIPT RN Organic anion transporting polypeptide 1B1: a genetically polymorphic transporter of major importance for hepatic drug uptake. Pharmacol Rev. 2011 Mar;63(1):157-81. DMGQIPT RU http://www.ncbi.nlm.nih.gov/pubmed/21245207 DMRSZA5 DI DMRSZA5 DMRSZA5 DN Cefacetrile DMRSZA5 MI TTJP4SM DMRSZA5 MN Bacterial Penicillin binding protein (Bact PBP) DMRSZA5 MT DTT DMRSZA5 MA Binder DMRSZA5 RN Single dose 1 g ceftriaxone for urogenital and pharyngeal infection caused by Neisseria gonorrhoeae. Int J Urol. 2008 Sep;15(9):837-42. DMRSZA5 RU https://pubmed.ncbi.nlm.nih.gov/18665871 DMJXDGC DI DMJXDGC DMJXDGC DN Cefaclor DMJXDGC MI TTJP4SM DMJXDGC MN Bacterial Penicillin binding protein (Bact PBP) DMJXDGC MT DTT DMJXDGC MA Binder DMJXDGC RN Antibacterial activity of oral cephems against various clinically isolated strains and evaluation of efficacy based on the pharmacokinetics/pharmacodynamics theory. Jpn J Antibiot. 2004 Dec;57(6):465-74. DMJXDGC RU https://pubmed.ncbi.nlm.nih.gov/15747584 DMJXDGC DI DMJXDGC DMJXDGC DN Cefaclor DMJXDGC MI DTQ23VB DMJXDGC MN Organic anion transporter 1 (SLC22A6) DMJXDGC MT DTP DMJXDGC MA Substrate DMJXDGC RN FDA Drug Development and Drug Interactions DMJXDGC RU https://www.fda.gov/drugs/developmentapprovalprocess/developmentresources/druginteractionslabeling/ucm093664.htm#table3-2 DMJXDGC DI DMJXDGC DMJXDGC DN Cefaclor DMJXDGC MI DTVP67E DMJXDGC MN Organic anion transporter 3 (SLC22A8) DMJXDGC MT DTP DMJXDGC MA Substrate DMJXDGC RN Human organic anion transporter hOAT3 is a potent transporter of cephalosporin antibiotics, in comparison with hOAT1. Biochem Pharmacol. 2005 Oct 1;70(7):1104-13. DMJXDGC RU http://www.ncbi.nlm.nih.gov/pubmed/16098483 DMJXDGC DI DMJXDGC DMJXDGC DN Cefaclor DMJXDGC MI DT9G7XN DMJXDGC MN Peptide transporter 1 (SLC15A1) DMJXDGC MT DTP DMJXDGC MA Substrate DMJXDGC RN Protein hydrolysate-induced cholecystokinin secretion from enteroendocrine cells is indirectly mediated by the intestinal oligopeptide transporter PepT1. Am J Physiol Gastrointest Liver Physiol. 2011 May;300(5):G895-902. DMJXDGC RU http://www.ncbi.nlm.nih.gov/pubmed/21311026 DMJXDGC DI DMJXDGC DMJXDGC DN Cefaclor DMJXDGC MI DT8QKNP DMJXDGC MN Peptide transporter 2 (SLC15A2) DMJXDGC MT DTP DMJXDGC MA Substrate DMJXDGC RN Interactions of amoxicillin and cefaclor with human renal organic anion and peptide transporters. Drug Metab Dispos. 2006 Apr;34(4):547-55. DMJXDGC RU http://www.ncbi.nlm.nih.gov/pubmed/16434549 DMMC345 DI DMMC345 DMMC345 DN Cefadroxil DMMC345 MI TTJP4SM DMMC345 MN Bacterial Penicillin binding protein (Bact PBP) DMMC345 MT DTT DMMC345 MA Binder DMMC345 RN Penicillin-binding protein sensitive to cephalexin in sporulation of Bacillus cereus. Microbiol Res. 1997 Sep;152(3):227-32. DMMC345 RU https://pubmed.ncbi.nlm.nih.gov/9352657 DMMC345 DI DMMC345 DMMC345 DN Cefadroxil DMMC345 MI DTSYQGK DMMC345 MN Multidrug resistance-associated protein 1 (ABCC1) DMMC345 MT DTP DMMC345 MA Substrate DMMC345 RN Oral availability of cefadroxil depends on ABCC3 and ABCC4. Drug Metab Dispos. 2012 Mar;40(3):515-21. DMMC345 RU http://www.ncbi.nlm.nih.gov/pubmed/22166395 DMMC345 DI DMMC345 DMMC345 DN Cefadroxil DMMC345 MI DTFI42L DMMC345 MN Multidrug resistance-associated protein 2 (ABCC2) DMMC345 MT DTP DMMC345 MA Substrate DMMC345 RN Oral availability of cefadroxil depends on ABCC3 and ABCC4. Drug Metab Dispos. 2012 Mar;40(3):515-21. DMMC345 RU http://www.ncbi.nlm.nih.gov/pubmed/22166395 DMMC345 DI DMMC345 DMMC345 DN Cefadroxil DMMC345 MI DTQ3ZHF DMMC345 MN Multidrug resistance-associated protein 3 (ABCC3) DMMC345 MT DTP DMMC345 MA Substrate DMMC345 RN Oral availability of cefadroxil depends on ABCC3 and ABCC4. Drug Metab Dispos. 2012 Mar;40(3):515-21. DMMC345 RU http://www.ncbi.nlm.nih.gov/pubmed/22166395 DMMC345 DI DMMC345 DMMC345 DN Cefadroxil DMMC345 MI DTCSGPB DMMC345 MN Multidrug resistance-associated protein 4 (ABCC4) DMMC345 MT DTP DMMC345 MA Substrate DMMC345 RN Oral availability of cefadroxil depends on ABCC3 and ABCC4. Drug Metab Dispos. 2012 Mar;40(3):515-21. DMMC345 RU http://www.ncbi.nlm.nih.gov/pubmed/22166395 DMMC345 DI DMMC345 DMMC345 DN Cefadroxil DMMC345 MI DEIU0XN DMMC345 MN N-acylhomoserine lactone acylase (lacA) DMMC345 MT DME DMMC345 MA Metabolism DMMC345 RN A novel quorum-quenching N-acylhomoserine lactone acylase from Acidovorax sp. strain MR-S7 mediates antibiotic resistance. Appl Environ Microbiol. 2017 Jun 16;83(13). pii: e00080-17. DMMC345 RU https://pubmed.ncbi.nlm.nih.gov/28455333 DMMC345 DI DMMC345 DMMC345 DN Cefadroxil DMMC345 MI DT9G7XN DMMC345 MN Peptide transporter 1 (SLC15A1) DMMC345 MT DTP DMMC345 MA Substrate DMMC345 RN High-affinity interaction of sartans with H+/peptide transporters. Drug Metab Dispos. 2009 Jan;37(1):143-9. DMMC345 RU http://www.ncbi.nlm.nih.gov/pubmed/18824524 DMMC345 DI DMMC345 DMMC345 DN Cefadroxil DMMC345 MI DT8QKNP DMMC345 MN Peptide transporter 2 (SLC15A2) DMMC345 MT DTP DMMC345 MA Substrate DMMC345 RN Species Differences in Human and Rodent PEPT2-Mediated Transport of Glycylsarcosine and Cefadroxil in Pichia Pastoris Transformants. Drug Metab Dispos. 2017 Feb;45(2):130-136. DMMC345 RU http://www.ncbi.nlm.nih.gov/pubmed/27836942 DMVYSLE DI DMVYSLE DMVYSLE DN Cefalotin DMVYSLE MI DERI7LO DMVYSLE MN AmpC beta-lactamase (ampC) DMVYSLE MT DME DMVYSLE MA Metabolism DMVYSLE RN Characterization of the AmpC beta-Lactamase from Burkholderia multivorans. Antimicrob Agents Chemother. 2018 Sep 24;62(10). pii: e01140-18. DMVYSLE RU https://pubmed.ncbi.nlm.nih.gov/30012762 DMVYSLE DI DMVYSLE DMVYSLE DN Cefalotin DMVYSLE MI TTLP6GN DMVYSLE MN Bacterial DD-carboxypeptidase (Bact vanYB) DMVYSLE MT DTT DMVYSLE MA Inhibitor DMVYSLE RN Binding of cephalothin and cefotaxime to D-ala-D-ala-peptidase reveals a functional basis of a natural mutation in a low-affinity penicillin-binding protein and in extended-spectrum beta-lactamases. Biochemistry. 1995 Jul 25;34(29):9532-40. DMVYSLE RU https://pubmed.ncbi.nlm.nih.gov/7626623 DMVYSLE DI DMVYSLE DMVYSLE DN Cefalotin DMVYSLE MI DET9I1W DMVYSLE MN Beta-lactamase (blaB) DMVYSLE MT DME DMVYSLE MA Metabolism DMVYSLE RN Purification and characterization of a new beta-lactamase from Bacteroides uniformis. Antimicrob Agents Chemother. 1995 Jul;39(7):1458-61. DMVYSLE RU https://pubmed.ncbi.nlm.nih.gov/7492085 DMVYSLE DI DMVYSLE DMVYSLE DN Cefalotin DMVYSLE MI DENJ2SQ DMVYSLE MN Beta-lactamase (blaB) DMVYSLE MT DME DMVYSLE MA Metabolism DMVYSLE RN Antibacterial activity of cefoperazone against anaerobic bacteria (author's transl). Jpn J Antibiot. 1980 Nov;33(11):1171-82. DMVYSLE RU https://pubmed.ncbi.nlm.nih.gov/6454011 DMNEXZF DI DMNEXZF DMNEXZF DN Cefamandole DMNEXZF MI TTJP4SM DMNEXZF MN Bacterial Penicillin binding protein (Bact PBP) DMNEXZF MT DTT DMNEXZF MA Binder DMNEXZF RN The impact of penicillinase on cefamandole treatment and prophylaxis of experimental endocarditis due to methicillin-resistant Staphylococcus aureus. J Infect Dis. 1998 Jan;177(1):146-54. DMNEXZF RU https://pubmed.ncbi.nlm.nih.gov/9419181 DMNEXZF DI DMNEXZF DMNEXZF DN Cefamandole DMNEXZF MI DT9G7XN DMNEXZF MN Peptide transporter 1 (SLC15A1) DMNEXZF MT DTP DMNEXZF MA Substrate DMNEXZF RN Intestinal transport of beta-lactam antibiotics: analysis of the affinity at the H+/peptide symporter (PEPT1), the uptake into Caco-2 cell monolayers and the transepithelial flux. Pharm Res. 1999 Jan;16(1):55-61. DMNEXZF RU https://doi.org/10.1023/A:1018814627484 DMPDYFR DI DMPDYFR DMPDYFR DN Cefazolin DMPDYFR MI TTJP4SM DMPDYFR MN Bacterial Penicillin binding protein (Bact PBP) DMPDYFR MT DTT DMPDYFR MA Binder DMPDYFR RN Bacteriological characteristics of Staphylococcus aureus isolates from humans and bulk milk. J Dairy Sci. 2008 Feb;91(2):564-9. DMPDYFR RU https://pubmed.ncbi.nlm.nih.gov/18218742 DMPDYFR DI DMPDYFR DMPDYFR DN Cefazolin DMPDYFR MI DEP0IWS DMPDYFR MN Beta-lactamase (blaB) DMPDYFR MT DME DMPDYFR MA Metabolism DMPDYFR RN Analysis of the drug-resistant characteristics of Klebsiella pneumoniae isolated from the respiratory tract and CTX-M ESBL genes. Genet Mol Res. 2015 Oct 5;14(4):12043-8. DMPDYFR RU https://pubmed.ncbi.nlm.nih.gov/26505351 DMPDYFR DI DMPDYFR DMPDYFR DN Cefazolin DMPDYFR MI DE7IH52 DMPDYFR MN Beta-lactamase (blaB) DMPDYFR MT DME DMPDYFR MA Metabolism DMPDYFR RN Citrobacter freundii bacteremia: Risk factors of mortality and prevalence of resistance genes. J Microbiol Immunol Infect. 2018 Aug;51(4):565-572. DMPDYFR RU https://pubmed.ncbi.nlm.nih.gov/28711438 DMPDYFR DI DMPDYFR DMPDYFR DN Cefazolin DMPDYFR MI DENJ2SQ DMPDYFR MN Beta-lactamase (blaB) DMPDYFR MT DME DMPDYFR MA Metabolism DMPDYFR RN Prevalence of antimicrobial resistance genes in Bacteroides spp. and Prevotella spp. Dutch clinical isolates. Clin Microbiol Infect. 2019 Sep;25(9):1156.e9-1156.e13. DMPDYFR RU https://pubmed.ncbi.nlm.nih.gov/30802650 DMPDYFR DI DMPDYFR DMPDYFR DN Cefazolin DMPDYFR MI DTCSGPB DMPDYFR MN Multidrug resistance-associated protein 4 (ABCC4) DMPDYFR MT DTP DMPDYFR MA Substrate DMPDYFR RN Oral availability of cefadroxil depends on ABCC3 and ABCC4. Drug Metab Dispos. 2012 Mar;40(3):515-21. DMPDYFR RU http://www.ncbi.nlm.nih.gov/pubmed/22166395 DMPDYFR DI DMPDYFR DMPDYFR DN Cefazolin DMPDYFR MI DTQ23VB DMPDYFR MN Organic anion transporter 1 (SLC22A6) DMPDYFR MT DTP DMPDYFR MA Substrate DMPDYFR RN Expression levels of renal organic anion transporters (OATs) and their correlation with anionic drug excretion in patients with renal diseases. Pharm Res. 2004 Jan;21(1):61-7. DMPDYFR RU http://www.ncbi.nlm.nih.gov/pubmed/14984259 DMPDYFR DI DMPDYFR DMPDYFR DN Cefazolin DMPDYFR MI DTVP67E DMPDYFR MN Organic anion transporter 3 (SLC22A8) DMPDYFR MT DTP DMPDYFR MA Substrate DMPDYFR RN Expression levels of renal organic anion transporters (OATs) and their correlation with anionic drug excretion in patients with renal diseases. Pharm Res. 2004 Jan;21(1):61-7. DMPDYFR RU http://www.ncbi.nlm.nih.gov/pubmed/14984259 DMPDYFR DI DMPDYFR DMPDYFR DN Cefazolin DMPDYFR MI DT3D8F0 DMPDYFR MN Organic anion transporting polypeptide 1B1 (SLCO1B1) DMPDYFR MT DTP DMPDYFR MA Substrate DMPDYFR RN Organic anion transporting polypeptide 1B1: a genetically polymorphic transporter of major importance for hepatic drug uptake. Pharmacol Rev. 2011 Mar;63(1):157-81. DMPDYFR RU http://www.ncbi.nlm.nih.gov/pubmed/21245207 DMPDYFR DI DMPDYFR DMPDYFR DN Cefazolin DMPDYFR MI DT9G7XN DMPDYFR MN Peptide transporter 1 (SLC15A1) DMPDYFR MT DTP DMPDYFR MA Substrate DMPDYFR RN Three-dimensional quantitative structure-activity relationship analyses of beta-lactam antibiotics and tripeptides as substrates of the mammalian H+/peptide cotransporter PEPT1. J Med Chem. 2005 Jun 30;48(13):4410-9. DMPDYFR RU http://www.ncbi.nlm.nih.gov/pubmed/15974593 DMPDYFR DI DMPDYFR DMPDYFR DN Cefazolin DMPDYFR MI DEFQ8VO DMPDYFR MN Thiopurine methyltransferase (TPMT) DMPDYFR MT DME DMPDYFR MA Metabolism DMPDYFR RN Cefazolin administration and 2-methyl-1,3,4-thiadiazole-5-thiol in human tissue: possible relationship to hypoprothrombinemia. Drug Metab Dispos. 2002 Oct;30(10):1123-8. DMPDYFR RU https://www.ncbi.nlm.nih.gov/pubmed/?term=12228189 DMJ7A0H DI DMJ7A0H DMJ7A0H DN Cefdinir DMJ7A0H MI TTJP4SM DMJ7A0H MN Bacterial Penicillin binding protein (Bact PBP) DMJ7A0H MT DTT DMJ7A0H MA Binder DMJ7A0H RN Decreased affinity of mosaic-structure recombinant penicillin-binding protein 2 for oral cephalosporins in Neisseria gonorrhoeae. J Antimicrob Chemother. 2007 Jul;60(1):54-60. DMJ7A0H RU https://pubmed.ncbi.nlm.nih.gov/17540669 DMJ7A0H DI DMJ7A0H DMJ7A0H DN Cefdinir DMJ7A0H MI DTVP67E DMJ7A0H MN Organic anion transporter 3 (SLC22A8) DMJ7A0H MT DTP DMJ7A0H MA Substrate DMJ7A0H RN Human organic anion transporter hOAT3 is a potent transporter of cephalosporin antibiotics, in comparison with hOAT1. Biochem Pharmacol. 2005 Oct 1;70(7):1104-13. DMJ7A0H RU http://www.ncbi.nlm.nih.gov/pubmed/16098483 DMJ7A0H DI DMJ7A0H DMJ7A0H DN Cefdinir DMJ7A0H MI DT9G7XN DMJ7A0H MN Peptide transporter 1 (SLC15A1) DMJ7A0H MT DTP DMJ7A0H MA Substrate DMJ7A0H RN Transporter-mediated drug delivery: recent progress and experimental approaches. Drug Discov Today. 2004 Aug 15;9(16):712-20. DMJ7A0H RU https://doi.org/10.1016/S1359-6446(04)03198-8 DMSUVM1 DI DMSUVM1 DMSUVM1 DN Cefditoren DMSUVM1 MI TTJP4SM DMSUVM1 MN Bacterial Penicillin binding protein (Bact PBP) DMSUVM1 MT DTT DMSUVM1 MA Binder DMSUVM1 RN Crystal structure of cefditoren complexed with Streptococcus pneumoniae penicillin-binding protein 2X: structural basis for its high antimicrobial ... Antimicrob Agents Chemother. 2007 Nov;51(11):3902-7. DMSUVM1 RU https://pubmed.ncbi.nlm.nih.gov/17724158 DMSUVM1 DI DMSUVM1 DMSUVM1 DN Cefditoren DMSUVM1 MI DT3D8F0 DMSUVM1 MN Organic anion transporting polypeptide 1B1 (SLCO1B1) DMSUVM1 MT DTP DMSUVM1 MA Substrate DMSUVM1 RN Organic anion transporting polypeptide 1B1: a genetically polymorphic transporter of major importance for hepatic drug uptake. Pharmacol Rev. 2011 Mar;63(1):157-81. DMSUVM1 RU http://www.ncbi.nlm.nih.gov/pubmed/21245207 DMHVWIK DI DMHVWIK DMHVWIK DN Cefepime DMHVWIK MI TTHWB7G DMHVWIK MN Bacterial Penicillin binding protein 2 (Bact mrdA) DMHVWIK MT DTT DMHVWIK MA Modulator DMHVWIK RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. DMHVWIK RU https://www.fda.gov/ DMY60I8 DI DMY60I8 DMY60I8 DN Cefixime DMY60I8 MI TTJP4SM DMY60I8 MN Bacterial Penicillin binding protein (Bact PBP) DMY60I8 MT DTT DMY60I8 MA Binder DMY60I8 RN Genetics of chromosomally mediated intermediate resistance to ceftriaxone and cefixime in Neisseria gonorrhoeae. Antimicrob Agents Chemother. 2009 Sep;53(9):3744-51. DMY60I8 RU https://pubmed.ncbi.nlm.nih.gov/19528266 DMY60I8 DI DMY60I8 DMY60I8 DN Cefixime DMY60I8 MI DT9G7XN DMY60I8 MN Peptide transporter 1 (SLC15A1) DMY60I8 MT DTP DMY60I8 MA Substrate DMY60I8 RN Flavonoids with epidermal growth factor-receptor tyrosine kinase inhibitory activity stimulate PEPT1-mediated cefixime uptake into human intestinal epithelial cells. J Pharmacol Exp Ther. 2001 Oct;299(1):351-7. DMY60I8 RU http://www.ncbi.nlm.nih.gov/pubmed/11561098 DMY60I8 DI DMY60I8 DMY60I8 DN Cefixime DMY60I8 MI DT8QKNP DMY60I8 MN Peptide transporter 2 (SLC15A2) DMY60I8 MT DTP DMY60I8 MA Substrate DMY60I8 RN Transport characteristics of a novel peptide transporter 1 substrate, antihypotensive drug midodrine, and its amino acid derivatives. J Pharmacol Exp Ther. 2006 Jul;318(1):455-60. DMY60I8 RU http://www.ncbi.nlm.nih.gov/pubmed/16597710 DMPLY7B DI DMPLY7B DMPLY7B DN Cefmenoxime DMPLY7B MI TT85JMW DMPLY7B MN Bacterial Penicillin binding protein 3 (Bact mrcA) DMPLY7B MT DTT DMPLY7B MA Binder DMPLY7B RN In vitro evaluation of E1040, a new cephalosporin with potent antipseudomonal activity. Antimicrob Agents Chemother. 1988 May;32(5):693-701. DMPLY7B RU https://pubmed.ncbi.nlm.nih.gov/3134847 DM42W1B DI DM42W1B DM42W1B DN Cefmetazole DM42W1B MI TT85JMW DM42W1B MN Bacterial Penicillin binding protein 3 (Bact mrcA) DM42W1B MT DTT DM42W1B MA Binder DM42W1B RN Clinical relevance of antibiotic-induced endotoxin release in patients undergoing hepatic resection. World J Surg. 1999 Jan;23(1):75-9. DM42W1B RU https://pubmed.ncbi.nlm.nih.gov/9841767 DM42W1B DI DM42W1B DM42W1B DN Cefmetazole DM42W1B MI DT9C1TS DM42W1B MN Organic anion transporting polypeptide 1B3 (SLCO1B3) DM42W1B MT DTP DM42W1B MA Substrate DM42W1B RN Screening of antibiotics that interact with organic anion-transporting polypeptides 1B1 and 1B3 using fluorescent probes. Biol Pharm Bull. 2011;34(3):389-95. DM42W1B RU http://www.ncbi.nlm.nih.gov/pubmed/21372390 DM42W1B DI DM42W1B DM42W1B DN Cefmetazole DM42W1B MI DT9G7XN DM42W1B MN Peptide transporter 1 (SLC15A1) DM42W1B MT DTP DM42W1B MA Substrate DM42W1B RN Intestinal transport of beta-lactam antibiotics: analysis of the affinity at the H+/peptide symporter (PEPT1), the uptake into Caco-2 cell monolayers and the transepithelial flux. Pharm Res. 1999 Jan;16(1):55-61. DM42W1B RU https://doi.org/10.1023/A:1018814627484 DMORSGU DI DMORSGU DMORSGU DN Cefodizime DMORSGU MI DTFI42L DMORSGU MN Multidrug resistance-associated protein 2 (ABCC2) DMORSGU MT DTP DMORSGU MA Substrate DMORSGU RN Mammalian drug efflux transporters of the ATP binding cassette (ABC) family in multidrug resistance: A review of the past decade. Cancer Lett. 2016 Jan 1;370(1):153-64. DMORSGU RU http://www.ncbi.nlm.nih.gov/pubmed/26499806 DMTX2BH DI DMTX2BH DMTX2BH DN Cefonicid DMTX2BH MI TTJP4SM DMTX2BH MN Bacterial Penicillin binding protein (Bact PBP) DMTX2BH MT DTT DMTX2BH MA Binder DMTX2BH RN Affinity of cefonicid, a long-acting cephalosporin, for the penicillin-binding proteins of Escherichia coli K-12. J Antibiot (Tokyo). 1984 May;37(5):572-6. DMTX2BH RU https://pubmed.ncbi.nlm.nih.gov/6376452 DM53PV8 DI DM53PV8 DM53PV8 DN Cefoperazone DM53PV8 MI TTJP4SM DM53PV8 MN Bacterial Penicillin binding protein (Bact PBP) DM53PV8 MT DTT DM53PV8 MA Binder DM53PV8 RN Clinical relevance of antibiotic-induced endotoxin release in patients undergoing hepatic resection. World J Surg. 1999 Jan;23(1):75-9. DM53PV8 RU https://pubmed.ncbi.nlm.nih.gov/9841767 DM53PV8 DI DM53PV8 DM53PV8 DN Cefoperazone DM53PV8 MI DT3D8F0 DM53PV8 MN Organic anion transporting polypeptide 1B1 (SLCO1B1) DM53PV8 MT DTP DM53PV8 MA Substrate DM53PV8 RN Organic anion transporting polypeptide 1B1: a genetically polymorphic transporter of major importance for hepatic drug uptake. Pharmacol Rev. 2011 Mar;63(1):157-81. DM53PV8 RU http://www.ncbi.nlm.nih.gov/pubmed/21245207 DM53PV8 DI DM53PV8 DM53PV8 DN Cefoperazone DM53PV8 MI DT9C1TS DM53PV8 MN Organic anion transporting polypeptide 1B3 (SLCO1B3) DM53PV8 MT DTP DM53PV8 MA Substrate DM53PV8 RN Screening of antibiotics that interact with organic anion-transporting polypeptides 1B1 and 1B3 using fluorescent probes. Biol Pharm Bull. 2011;34(3):389-95. DM53PV8 RU http://www.ncbi.nlm.nih.gov/pubmed/21372390 DM53PV8 DI DM53PV8 DM53PV8 DN Cefoperazone DM53PV8 MI DTUGYRD DM53PV8 MN P-glycoprotein 1 (ABCB1) DM53PV8 MT DTP DM53PV8 MA Substrate DM53PV8 RN Mammalian drug efflux transporters of the ATP binding cassette (ABC) family in multidrug resistance: A review of the past decade. Cancer Lett. 2016 Jan 1;370(1):153-64. DM53PV8 RU http://www.ncbi.nlm.nih.gov/pubmed/26499806 DMSQVD6 DI DMSQVD6 DMSQVD6 DN Ceforanide DMSQVD6 MI TTJP4SM DMSQVD6 MN Bacterial Penicillin binding protein (Bact PBP) DMSQVD6 MT DTT DMSQVD6 MA Binder DMSQVD6 RN The pharmacokinetics of the interstitial space in humans. BMC Clin Pharmacol. 2003 Jul 30;3:3. DMSQVD6 RU https://pubmed.ncbi.nlm.nih.gov/12890292 DMEB837 DI DMEB837 DMEB837 DN Cefotaxime DMEB837 MI DE0TCN3 DMEB837 MN Ampc beta-lactamase (ampC) DMEB837 MT DME DMEB837 MA Metabolism DMEB837 RN Cell wall recycling-linked coregulation of AmpC and PenB beta-lactamases through ampD mutations in Burkholderia cenocepacia. Antimicrob Agents Chemother. 2015 Dec;59(12):7602-10. DMEB837 RU https://pubmed.ncbi.nlm.nih.gov/26416862 DMMKHBJ DI DMMKHBJ DMMKHBJ DN Cefotaxime DMMKHBJ MI TTLP6GN DMMKHBJ MN Bacterial DD-carboxypeptidase (Bact vanYB) DMMKHBJ MT DTT DMMKHBJ MA Inhibitor DMMKHBJ RN Extended-spectrum cephalosporinases: structure, detection and epidemiology. Future Microbiol. 2007 Jun;2:297-307. DMMKHBJ RU https://pubmed.ncbi.nlm.nih.gov/17661704 DMEB837 DI DMEB837 DMEB837 DN Cefotaxime DMEB837 MI DEAYSTX DMEB837 MN Beta-lactamase (blaB) DMEB837 MT DME DMEB837 MA Metabolism DMEB837 RN ACI-1 beta-lactamase is widespread across human gut microbiomes in Negativicutes due to transposons harboured by tailed prophages. Environ Microbiol. 2018 Jun;20(6):2288-2300. DMEB837 RU https://pubmed.ncbi.nlm.nih.gov/30014616 DMEB837 DI DMEB837 DMEB837 DN Cefotaxime DMEB837 MI DEITMS0 DMEB837 MN Beta-lactamase (blaB) DMEB837 MT DME DMEB837 MA Metabolism DMEB837 RN ACI-1 from Acidaminococcus fermentans: characterization of the first beta-lactamase in Anaerobic cocci. Antimicrob Agents Chemother. 2000 Nov;44(11):3144-9. DMEB837 RU https://pubmed.ncbi.nlm.nih.gov/11036038 DMEB837 DI DMEB837 DMEB837 DN Cefotaxime DMEB837 MI DEP0IWS DMEB837 MN Beta-lactamase (blaB) DMEB837 MT DME DMEB837 MA Metabolism DMEB837 RN Analysis of the drug-resistant characteristics of Klebsiella pneumoniae isolated from the respiratory tract and CTX-M ESBL genes. Genet Mol Res. 2015 Oct 5;14(4):12043-8. DMEB837 RU https://pubmed.ncbi.nlm.nih.gov/26505351 DMEB837 DI DMEB837 DMEB837 DN Cefotaxime DMEB837 MI DEEAL81 DMEB837 MN Beta-lactamase (blaB) DMEB837 MT DME DMEB837 MA Metabolism DMEB837 RN nan DMEB837 RU nan DMEB837 DI DMEB837 DMEB837 DN Cefotaxime DMEB837 MI DE7IH52 DMEB837 MN Beta-lactamase (blaB) DMEB837 MT DME DMEB837 MA Metabolism DMEB837 RN nan DMEB837 RU nan DMEB837 DI DMEB837 DMEB837 DN Cefotaxime DMEB837 MI DE5HV8P DMEB837 MN Beta-lactamase (blaB) DMEB837 MT DME DMEB837 MA Metabolism DMEB837 RN Presence of the cfxA gene in Bacteroides distasonis. Res Microbiol. 2003 Jun;154(5):369-74. DMEB837 RU https://pubmed.ncbi.nlm.nih.gov/12837513 DMEB837 DI DMEB837 DMEB837 DN Cefotaxime DMEB837 MI DE47ARF DMEB837 MN Beta-lactamase (blaB) DMEB837 MT DME DMEB837 MA Metabolism DMEB837 RN Presence of the cfxA gene in Bacteroides distasonis. Res Microbiol. 2003 Jun;154(5):369-74. DMEB837 RU https://pubmed.ncbi.nlm.nih.gov/12837513 DMEB837 DI DMEB837 DMEB837 DN Cefotaxime DMEB837 MI DEHJVX4 DMEB837 MN Beta-lactamase (blaB) DMEB837 MT DME DMEB837 MA Metabolism DMEB837 RN Presence of the cfxA gene in Bacteroides distasonis. Res Microbiol. 2003 Jun;154(5):369-74. DMEB837 RU https://pubmed.ncbi.nlm.nih.gov/12837513 DMEB837 DI DMEB837 DMEB837 DN Cefotaxime DMEB837 MI DEG2PK9 DMEB837 MN Beta-lactamase (blaB) DMEB837 MT DME DMEB837 MA Metabolism DMEB837 RN Presence of the cfxA gene in Bacteroides distasonis. Res Microbiol. 2003 Jun;154(5):369-74. DMEB837 RU https://pubmed.ncbi.nlm.nih.gov/12837513 DMEB837 DI DMEB837 DMEB837 DN Cefotaxime DMEB837 MI DEWHJ7A DMEB837 MN Beta-lactamase (blaB) DMEB837 MT DME DMEB837 MA Metabolism DMEB837 RN nan DMEB837 RU nan DMEB837 DI DMEB837 DMEB837 DN Cefotaxime DMEB837 MI DEU1RXB DMEB837 MN Beta-lactamase (blaB) DMEB837 MT DME DMEB837 MA Metabolism DMEB837 RN Presence of the cfxA gene in Bacteroides distasonis. Res Microbiol. 2003 Jun;154(5):369-74. DMEB837 RU https://pubmed.ncbi.nlm.nih.gov/12837513 DMEB837 DI DMEB837 DMEB837 DN Cefotaxime DMEB837 MI DEMIUB2 DMEB837 MN Beta-lactamase (blaB) DMEB837 MT DME DMEB837 MA Metabolism DMEB837 RN Oral streptococcal strains isolated from odontogenic infections and their susceptibility to antibiotics. Rev Med Chir Soc Med Nat Iasi. 2006 Oct-Dec;110(4):1012-5. DMEB837 RU https://pubmed.ncbi.nlm.nih.gov/17438917 DMEB837 DI DMEB837 DMEB837 DN Cefotaxime DMEB837 MI DEYIEO5 DMEB837 MN Beta-lactamase (blaB) DMEB837 MT DME DMEB837 MA Metabolism DMEB837 RN Determination of the antibiotic resistance rates of Serratia marcescens isolates obtained from various clinical specimens. Niger J Clin Pract. 2019 Jan;22(1):125-130. DMEB837 RU https://pubmed.ncbi.nlm.nih.gov/30666031 DMEB837 DI DMEB837 DMEB837 DN Cefotaxime DMEB837 MI DEVHXAU DMEB837 MN Beta-lactamase (blaB) DMEB837 MT DME DMEB837 MA Metabolism DMEB837 RN Cephalosporinases associated with outer membrane vesicles released by Bacteroides spp. protect gut pathogens and commensals against beta-lactam antibiotics. J Antimicrob Chemother. 2015 Mar;70(3):701-9. DMEB837 RU https://pubmed.ncbi.nlm.nih.gov/25433011 DMEB837 DI DMEB837 DMEB837 DN Cefotaxime DMEB837 MI DEZLFV5 DMEB837 MN Beta-lactamase (blaB) DMEB837 MT DME DMEB837 MA Metabolism DMEB837 RN Cell wall recycling-linked coregulation of AmpC and PenB beta-lactamases through ampD mutations in Burkholderia cenocepacia. Antimicrob Agents Chemother. 2015 Dec;59(12):7602-10. DMEB837 RU https://pubmed.ncbi.nlm.nih.gov/26416862 DMEB837 DI DMEB837 DMEB837 DN Cefotaxime DMEB837 MI DE5AHG6 DMEB837 MN Beta-lactamase (blaB) DMEB837 MT DME DMEB837 MA Metabolism DMEB837 RN Novel TEM-type extended-spectrum beta-lactamase, TEM-134, in a Citrobacter koseri clinical isolate. Antimicrob Agents Chemother. 2005 Apr;49(4):1564-6. DMEB837 RU https://pubmed.ncbi.nlm.nih.gov/15793140 DMEB837 DI DMEB837 DMEB837 DN Cefotaxime DMEB837 MI DEKGVS4 DMEB837 MN Beta-lactamase (blaB) DMEB837 MT DME DMEB837 MA Metabolism DMEB837 RN Overcoming an extremely drug resistant (XDR) pathogen: avibactam restores susceptibility to ceftazidime for Burkholderia cepacia complex isolates from cystic fibrosis patients. ACS Infect Dis. 2017 Jul 14;3(7):502-511. DMEB837 RU https://pubmed.ncbi.nlm.nih.gov/28264560 DMEB837 DI DMEB837 DMEB837 DN Cefotaxime DMEB837 MI DE2ARDZ DMEB837 MN PenA beta-lactamase (penA1) DMEB837 MT DME DMEB837 MA Metabolism DMEB837 RN Characterization of the penA and penR genes of Burkholderia cepacia 249 which encode the chromosomal class A penicillinase and its LysR-type transcriptional regulator. Antimicrob Agents Chemother. 1997 Nov;41(11):2399-405. DMEB837 RU https://pubmed.ncbi.nlm.nih.gov/9371340 DM07TX3 DI DM07TX3 DM07TX3 DN Cefotetan DM07TX3 MI TTJP4SM DM07TX3 MN Bacterial Penicillin binding protein (Bact PBP) DM07TX3 MT DTT DM07TX3 MA Binder DM07TX3 RN In-vitro profile of a new beta-lactam, ceftobiprole, with activity against methicillin-resistant Staphylococcus aureus. Clin Microbiol Infect. 2007 Jun;13 Suppl 2:17-24. DM07TX3 RU https://pubmed.ncbi.nlm.nih.gov/17488372 DM07TX3 DI DM07TX3 DM07TX3 DN Cefotetan DM07TX3 MI DTUGYRD DM07TX3 MN P-glycoprotein 1 (ABCB1) DM07TX3 MT DTP DM07TX3 MA Substrate DM07TX3 RN Human intestinal transporter database: QSAR modeling and virtual profiling of drug uptake, efflux and interactions. Pharm Res. 2013 Apr;30(4):996-1007. DM07TX3 RU https://doi.org/10.1007/s11095-012-0935-x DMF5HU6 DI DMF5HU6 DMF5HU6 DN Cefotiam DMF5HU6 MI TT85JMW DMF5HU6 MN Bacterial Penicillin binding protein 3 (Bact mrcA) DMF5HU6 MT DTT DMF5HU6 MA Binder DMF5HU6 RN Genetic analyses of beta-lactamase negative ampicillin-resistant strains of Haemophilus influenzae isolated in Okinawa, Japan. Jpn J Infect Dis. 2006 Feb;59(1):36-41. DMF5HU6 RU https://pubmed.ncbi.nlm.nih.gov/16495632 DMF5HU6 DI DMF5HU6 DMF5HU6 DN Cefotiam DMF5HU6 MI DTVP67E DMF5HU6 MN Organic anion transporter 3 (SLC22A8) DMF5HU6 MT DTP DMF5HU6 MA Substrate DMF5HU6 RN Adaptive responses of renal organic anion transporter 3 (OAT3) during cholestasis. Am J Physiol Renal Physiol. 2008 Jul;295(1):F247-52. DMF5HU6 RU http://www.ncbi.nlm.nih.gov/pubmed/18480179 DMYTXVR DI DMYTXVR DMYTXVR DN Cefoxitin DMYTXVR MI TTJP4SM DMYTXVR MN Bacterial Penicillin binding protein (Bact PBP) DMYTXVR MT DTT DMYTXVR MA Binder DMYTXVR RN Staphylococcus aureus PBP4 is essential for beta-lactam resistance in community-acquired methicillin-resistant strains. Antimicrob Agents Chemother. 2008 Nov;52(11):3955-66. DMYTXVR RU https://pubmed.ncbi.nlm.nih.gov/18725435 DMY8NC4 DI DMY8NC4 DMY8NC4 DN Cefoxitin DMY8NC4 MI DEP0IWS DMY8NC4 MN Beta-lactamase (blaB) DMY8NC4 MT DME DMY8NC4 MA Metabolism DMY8NC4 RN Analysis of the drug-resistant characteristics of Klebsiella pneumoniae isolated from the respiratory tract and CTX-M ESBL genes. Genet Mol Res. 2015 Oct 5;14(4):12043-8. DMY8NC4 RU https://pubmed.ncbi.nlm.nih.gov/26505351 DMY8NC4 DI DMY8NC4 DMY8NC4 DN Cefoxitin DMY8NC4 MI DEEAL81 DMY8NC4 MN Beta-lactamase (blaB) DMY8NC4 MT DME DMY8NC4 MA Metabolism DMY8NC4 RN nan DMY8NC4 RU nan DMY8NC4 DI DMY8NC4 DMY8NC4 DN Cefoxitin DMY8NC4 MI DE7IH52 DMY8NC4 MN Beta-lactamase (blaB) DMY8NC4 MT DME DMY8NC4 MA Metabolism DMY8NC4 RN Citrobacter freundii bacteremia: Risk factors of mortality and prevalence of resistance genes. J Microbiol Immunol Infect. 2018 Aug;51(4):565-572. DMY8NC4 RU https://pubmed.ncbi.nlm.nih.gov/28711438 DMY8NC4 DI DMY8NC4 DMY8NC4 DN Cefoxitin DMY8NC4 MI DE5HV8P DMY8NC4 MN Beta-lactamase (blaB) DMY8NC4 MT DME DMY8NC4 MA Metabolism DMY8NC4 RN Presence of the cfxA gene in Bacteroides distasonis. Res Microbiol. 2003 Jun;154(5):369-74. DMY8NC4 RU https://pubmed.ncbi.nlm.nih.gov/12837513 DMY8NC4 DI DMY8NC4 DMY8NC4 DN Cefoxitin DMY8NC4 MI DE47ARF DMY8NC4 MN Beta-lactamase (blaB) DMY8NC4 MT DME DMY8NC4 MA Metabolism DMY8NC4 RN Presence of the cfxA gene in Bacteroides distasonis. Res Microbiol. 2003 Jun;154(5):369-74. DMY8NC4 RU https://pubmed.ncbi.nlm.nih.gov/12837513 DMY8NC4 DI DMY8NC4 DMY8NC4 DN Cefoxitin DMY8NC4 MI DEHJVX4 DMY8NC4 MN Beta-lactamase (blaB) DMY8NC4 MT DME DMY8NC4 MA Metabolism DMY8NC4 RN Presence of the cfxA gene in Bacteroides distasonis. Res Microbiol. 2003 Jun;154(5):369-74. DMY8NC4 RU https://pubmed.ncbi.nlm.nih.gov/12837513 DMY8NC4 DI DMY8NC4 DMY8NC4 DN Cefoxitin DMY8NC4 MI DEG2PK9 DMY8NC4 MN Beta-lactamase (blaB) DMY8NC4 MT DME DMY8NC4 MA Metabolism DMY8NC4 RN Presence of the cfxA gene in Bacteroides distasonis. Res Microbiol. 2003 Jun;154(5):369-74. DMY8NC4 RU https://pubmed.ncbi.nlm.nih.gov/12837513 DMY8NC4 DI DMY8NC4 DMY8NC4 DN Cefoxitin DMY8NC4 MI DEWHJ7A DMY8NC4 MN Beta-lactamase (blaB) DMY8NC4 MT DME DMY8NC4 MA Metabolism DMY8NC4 RN Presence of the cfxA gene in Bacteroides distasonis. Res Microbiol. 2003 Jun;154(5):369-74. DMY8NC4 RU https://pubmed.ncbi.nlm.nih.gov/12837513 DMY8NC4 DI DMY8NC4 DMY8NC4 DN Cefoxitin DMY8NC4 MI DEU1RXB DMY8NC4 MN Beta-lactamase (blaB) DMY8NC4 MT DME DMY8NC4 MA Metabolism DMY8NC4 RN Presence of the cfxA gene in Bacteroides distasonis. Res Microbiol. 2003 Jun;154(5):369-74. DMY8NC4 RU https://pubmed.ncbi.nlm.nih.gov/12837513 DMY8NC4 DI DMY8NC4 DMY8NC4 DN Cefoxitin DMY8NC4 MI DEMIUB2 DMY8NC4 MN Beta-lactamase (blaB) DMY8NC4 MT DME DMY8NC4 MA Metabolism DMY8NC4 RN Oral streptococcal strains isolated from odontogenic infections and their susceptibility to antibiotics. Rev Med Chir Soc Med Nat Iasi. 2006 Oct-Dec;110(4):1012-5. DMY8NC4 RU https://pubmed.ncbi.nlm.nih.gov/17438917 DMY8NC4 DI DMY8NC4 DMY8NC4 DN Cefoxitin DMY8NC4 MI DEQAG48 DMY8NC4 MN Beta-lactamase (blaB) DMY8NC4 MT DME DMY8NC4 MA Metabolism DMY8NC4 RN Citrobacter koseri and Citrobacter amalonaticus isolates carry highly divergent beta-lactamase genes despite having high levels of biochemical similarity and 16S rRNA sequence homology. J Antimicrob Chemother. 2004 Jun;53(6):1076-80. DMY8NC4 RU https://pubmed.ncbi.nlm.nih.gov/15128725 DMY8NC4 DI DMY8NC4 DMY8NC4 DN Cefoxitin DMY8NC4 MI DEF01WC DMY8NC4 MN Beta-lactamase (blaB) DMY8NC4 MT DME DMY8NC4 MA Metabolism DMY8NC4 RN Beta-lactamase activity in Chromobacterium violaceum. J Infect Dis. 1976 Sep;134(3):290-3. DMY8NC4 RU https://pubmed.ncbi.nlm.nih.gov/977998 DMY8NC4 DI DMY8NC4 DMY8NC4 DN Cefoxitin DMY8NC4 MI DE5AHG6 DMY8NC4 MN Beta-lactamase (blaB) DMY8NC4 MT DME DMY8NC4 MA Metabolism DMY8NC4 RN Citrobacter koseri and Citrobacter amalonaticus isolates carry highly divergent beta-lactamase genes despite having high levels of biochemical similarity and 16S rRNA sequence homology. J Antimicrob Chemother. 2004 Jun;53(6):1076-80. DMY8NC4 RU https://pubmed.ncbi.nlm.nih.gov/15128725 DMYTXVR DI DMYTXVR DMYTXVR DN Cefoxitin DMYTXVR MI DT9G7XN DMYTXVR MN Peptide transporter 1 (SLC15A1) DMYTXVR MT DTP DMYTXVR MA Substrate DMYTXVR RN Three-dimensional quantitative structure-activity relationship analyses of beta-lactam antibiotics and tripeptides as substrates of the mammalian H+/peptide cotransporter PEPT1. J Med Chem. 2005 Jun 30;48(13):4410-9. DMYTXVR RU http://www.ncbi.nlm.nih.gov/pubmed/15974593 DMKBTFG DI DMKBTFG DMKBTFG DN Cefozopran DMKBTFG MI TT4ILYC DMKBTFG MN Bacterial Dihydropteroate synthetase (Bact folP) DMKBTFG MT DTT DMKBTFG MA Inhibitor DMKBTFG RN Emerging drugs for bacterial urinary tract infections. Expert Opin Emerg Drugs. 2005 May;10(2):275-98. DMKBTFG RU https://pubmed.ncbi.nlm.nih.gov/15934867 DMZ2WL4 DI DMZ2WL4 DMZ2WL4 DN Cefpiramide DMZ2WL4 MI TTJP4SM DMZ2WL4 MN Bacterial Penicillin binding protein (Bact PBP) DMZ2WL4 MT DTT DMZ2WL4 MA Binder DMZ2WL4 RN Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. DMZ2WL4 RU https://pubmed.ncbi.nlm.nih.gov/17016423 DMJUNY5 DI DMJUNY5 DMJUNY5 DN Cefpodoxime DMJUNY5 MI TTJP4SM DMJUNY5 MN Bacterial Penicillin binding protein (Bact PBP) DMJUNY5 MT DTT DMJUNY5 MA Binder DMJUNY5 RN Amino acid substitutions in mosaic penicillin-binding protein 2 associated with reduced susceptibility to cefixime in clinical isolates of Neisseri... Antimicrob Agents Chemother. 2006 Nov;50(11):3638-45. DMJUNY5 RU https://pubmed.ncbi.nlm.nih.gov/16940068 DMJUNY5 DI DMJUNY5 DMJUNY5 DN Cefpodoxime DMJUNY5 MI DEQAG48 DMJUNY5 MN Beta-lactamase (blaB) DMJUNY5 MT DME DMJUNY5 MA Metabolism DMJUNY5 RN Low-virulence Citrobacter species encode resistance to multiple antimicrobials. Antimicrob Agents Chemother. 2002 Nov;46(11):3555-60. DMJUNY5 RU https://pubmed.ncbi.nlm.nih.gov/12384364 DMJUNY5 DI DMJUNY5 DMJUNY5 DN Cefpodoxime DMJUNY5 MI DEEQ3RW DMJUNY5 MN Beta-lactamase (blaB) DMJUNY5 MT DME DMJUNY5 MA Metabolism DMJUNY5 RN Low-virulence Citrobacter species encode resistance to multiple antimicrobials. Antimicrob Agents Chemother. 2002 Nov;46(11):3555-60. DMJUNY5 RU https://pubmed.ncbi.nlm.nih.gov/12384364 DMJUNY5 DI DMJUNY5 DMJUNY5 DN Cefpodoxime DMJUNY5 MI DT9G7XN DMJUNY5 MN Peptide transporter 1 (SLC15A1) DMJUNY5 MT DTP DMJUNY5 MA Substrate DMJUNY5 RN Three-dimensional quantitative structure-activity relationship analyses of beta-lactam antibiotics and tripeptides as substrates of the mammalian H+/peptide cotransporter PEPT1. J Med Chem. 2005 Jun 30;48(13):4410-9. DMJUNY5 RU http://www.ncbi.nlm.nih.gov/pubmed/15974593 DM7DSYP DI DM7DSYP DM7DSYP DN Cefprozil DM7DSYP MI TTJP4SM DM7DSYP MN Bacterial Penicillin binding protein (Bact PBP) DM7DSYP MT DTT DM7DSYP MA Binder DM7DSYP RN Microbiology and antimicrobial management of sinusitis. J Laryngol Otol. 2005 Apr;119(4):251-8. DM7DSYP RU https://pubmed.ncbi.nlm.nih.gov/15949076 DMUNSWV DI DMUNSWV DMUNSWV DN Cefradine DMUNSWV MI TTJP4SM DMUNSWV MN Bacterial Penicillin binding protein (Bact PBP) DMUNSWV MT DTT DMUNSWV MA Binder DMUNSWV RN Staphylococcus aureus PBP4 is essential for beta-lactam resistance in community-acquired methicillin-resistant strains. Antimicrob Agents Chemother. 2008 Nov;52(11):3955-66. DMUNSWV RU https://pubmed.ncbi.nlm.nih.gov/18725435 DMUNSWV DI DMUNSWV DMUNSWV DN Cefradine DMUNSWV MI DT9G7XN DMUNSWV MN Peptide transporter 1 (SLC15A1) DMUNSWV MT DTP DMUNSWV MA Substrate DMUNSWV RN Recognition of beta-lactam antibiotics by rat peptide transporters, PEPT1 and PEPT2, in LLC-PK1 cells. Am J Physiol. 1997 Nov;273(5 Pt 2):F706-11. DMUNSWV RU http://www.ncbi.nlm.nih.gov/pubmed/9374833 DMUNSWV DI DMUNSWV DMUNSWV DN Cefradine DMUNSWV MI DT8QKNP DMUNSWV MN Peptide transporter 2 (SLC15A2) DMUNSWV MT DTP DMUNSWV MA Substrate DMUNSWV RN Transport characteristics of a novel peptide transporter 1 substrate, antihypotensive drug midodrine, and its amino acid derivatives. J Pharmacol Exp Ther. 2006 Jul;318(1):455-60. DMUNSWV RU http://www.ncbi.nlm.nih.gov/pubmed/16597710 DMQXLF3 DI DMQXLF3 DMQXLF3 DN Cefsulodin DMQXLF3 MI DT9G7XN DMQXLF3 MN Peptide transporter 1 (SLC15A1) DMQXLF3 MT DTP DMQXLF3 MA Substrate DMQXLF3 RN Intestinal transport of beta-lactam antibiotics: analysis of the affinity at the H+/peptide symporter (PEPT1), the uptake into Caco-2 cell monolayers and the transepithelial flux. Pharm Res. 1999 Jan;16(1):55-61. DMQXLF3 RU https://doi.org/10.1023/A:1018814627484 DM41GRA DI DM41GRA DM41GRA DN Ceftazidime DM41GRA MI TTJP4SM DM41GRA MN Bacterial Penicillin binding protein (Bact PBP) DM41GRA MT DTT DM41GRA MA Binder DM41GRA RN New and emerging treatment of Staphylococcus aureus infections in the hospital setting. Clin Microbiol Infect. 2008 Apr;14 Suppl 3:32-41. DM41GRA RU https://pubmed.ncbi.nlm.nih.gov/18318877 DMWV2AG DI DMWV2AG DMWV2AG DN Ceftibuten DMWV2AG MI TTJP4SM DMWV2AG MN Bacterial Penicillin binding protein (Bact PBP) DMWV2AG MT DTT DMWV2AG MA Binder DMWV2AG RN Neisseria gonorrhoeae and emerging resistance to extended spectrum cephalosporins. Curr Opin Infect Dis. 2009 Feb;22(1):87-91. DMWV2AG RU https://pubmed.ncbi.nlm.nih.gov/19532086 DMWV2AG DI DMWV2AG DMWV2AG DN Ceftibuten DMWV2AG MI DT9G7XN DMWV2AG MN Peptide transporter 1 (SLC15A1) DMWV2AG MT DTP DMWV2AG MA Substrate DMWV2AG RN Increased protein level of PEPT1 intestinal H+-peptide cotransporter upregulates absorption of glycylsarcosine and ceftibuten in 5/6 nephrectomized rats. Am J Physiol Gastrointest Liver Physiol. 2005 Apr;288(4):G664-70. DMWV2AG RU http://www.ncbi.nlm.nih.gov/pubmed/15528259 DMWV2AG DI DMWV2AG DMWV2AG DN Ceftibuten DMWV2AG MI DT8QKNP DMWV2AG MN Peptide transporter 2 (SLC15A2) DMWV2AG MT DTP DMWV2AG MA Substrate DMWV2AG RN Transport characteristics of a novel peptide transporter 1 substrate, antihypotensive drug midodrine, and its amino acid derivatives. J Pharmacol Exp Ther. 2006 Jul;318(1):455-60. DMWV2AG RU http://www.ncbi.nlm.nih.gov/pubmed/16597710 DMR2SOZ DI DMR2SOZ DMR2SOZ DN Ceftiofur DMR2SOZ MI DE3FVRW DMR2SOZ MN Beta-lactamase (blaB) DMR2SOZ MT DME DMR2SOZ MA Metabolism DMR2SOZ RN The bacterial degradation of chloramphenico. Lancet. 1967 Jun 10;1(7502):1259-60. DMR2SOZ RU https://pubmed.ncbi.nlm.nih.gov/4165044 DMR2SOZ DI DMR2SOZ DMR2SOZ DN Ceftiofur DMR2SOZ MI DEYM2D3 DMR2SOZ MN Beta-lactamase (blaB) DMR2SOZ MT DME DMR2SOZ MA Metabolism DMR2SOZ RN Bovine intestinal bacteria inactivate and degrade ceftiofur and ceftriaxone with multiple beta-lactamases. Antimicrob Agents Chemother. 2011 Nov;55(11):4990-8. DMR2SOZ RU https://pubmed.ncbi.nlm.nih.gov/21876048 DMR2SOZ DI DMR2SOZ DMR2SOZ DN Ceftiofur DMR2SOZ MI DE9ZQ3L DMR2SOZ MN Beta-lactamase (blaB) DMR2SOZ MT DME DMR2SOZ MA Metabolism DMR2SOZ RN Bovine intestinal bacteria inactivate and degrade ceftiofur and ceftriaxone with multiple beta-lactamases. Antimicrob Agents Chemother. 2011 Nov;55(11):4990-8. DMR2SOZ RU https://pubmed.ncbi.nlm.nih.gov/21876048 DMR2SOZ DI DMR2SOZ DMR2SOZ DN Ceftiofur DMR2SOZ MI DE69OXF DMR2SOZ MN Beta-lactamase (blaB) DMR2SOZ MT DME DMR2SOZ MA Metabolism DMR2SOZ RN Bovine intestinal bacteria inactivate and degrade ceftiofur and ceftriaxone with multiple beta-lactamases. Antimicrob Agents Chemother. 2011 Nov;55(11):4990-8. DMR2SOZ RU https://pubmed.ncbi.nlm.nih.gov/21876048 DMR2SOZ DI DMR2SOZ DMR2SOZ DN Ceftiofur DMR2SOZ MI DEPYGS9 DMR2SOZ MN Beta-lactamase (blaB) DMR2SOZ MT DME DMR2SOZ MA Metabolism DMR2SOZ RN Bovine intestinal bacteria inactivate and degrade ceftiofur and ceftriaxone with multiple beta-lactamases. Antimicrob Agents Chemother. 2011 Nov;55(11):4990-8. DMR2SOZ RU https://pubmed.ncbi.nlm.nih.gov/21876048 DMR2SOZ DI DMR2SOZ DMR2SOZ DN Ceftiofur DMR2SOZ MI DEPGFHV DMR2SOZ MN Beta-lactamase (blaB) DMR2SOZ MT DME DMR2SOZ MA Metabolism DMR2SOZ RN Isolation of bacterial strains from bovine fecal microflora capable of degradation of ceftiofur. Vet Microbiol. 2009 Oct 20;139(1-2):89-96. DMR2SOZ RU https://pubmed.ncbi.nlm.nih.gov/19428193 DMR2SOZ DI DMR2SOZ DMR2SOZ DN Ceftiofur DMR2SOZ MI DENZLGX DMR2SOZ MN Beta-lactamase (blaB) DMR2SOZ MT DME DMR2SOZ MA Metabolism DMR2SOZ RN Isolation of bacterial strains from bovine fecal microflora capable of degradation of ceftiofur. Vet Microbiol. 2009 Oct 20;139(1-2):89-96. DMR2SOZ RU https://pubmed.ncbi.nlm.nih.gov/19428193 DMR2SOZ DI DMR2SOZ DMR2SOZ DN Ceftiofur DMR2SOZ MI DEZAQPD DMR2SOZ MN Beta-lactamase (blaB) DMR2SOZ MT DME DMR2SOZ MA Metabolism DMR2SOZ RN Isolation of bacterial strains from bovine fecal microflora capable of degradation of ceftiofur. Vet Microbiol. 2009 Oct 20;139(1-2):89-96. DMR2SOZ RU https://pubmed.ncbi.nlm.nih.gov/19428193 DM3VOGS DI DM3VOGS DM3VOGS DN Ceftizoxime DM3VOGS MI TTJP4SM DM3VOGS MN Bacterial Penicillin binding protein (Bact PBP) DM3VOGS MT DTT DM3VOGS MA Binder DM3VOGS RN Role of penicillin-binding protein 2 (PBP2) in the antibiotic susceptibility and cell wall cross-linking of Staphylococcus aureus: evidence for the cooperative functioning of PBP2, PBP4, and PBP2A. JBacteriol. 2005 Mar;187(5):1815-24. DM3VOGS RU https://pubmed.ncbi.nlm.nih.gov/15716453 DM3VOGS DI DM3VOGS DM3VOGS DN Ceftizoxime DM3VOGS MI DTCSGPB DM3VOGS MN Multidrug resistance-associated protein 4 (ABCC4) DM3VOGS MT DTP DM3VOGS MA Substrate DM3VOGS RN Oral availability of cefadroxil depends on ABCC3 and ABCC4. Drug Metab Dispos. 2012 Mar;40(3):515-21. DM3VOGS RU http://www.ncbi.nlm.nih.gov/pubmed/22166395 DM3VOGS DI DM3VOGS DM3VOGS DN Ceftizoxime DM3VOGS MI DTQ23VB DM3VOGS MN Organic anion transporter 1 (SLC22A6) DM3VOGS MT DTP DM3VOGS MA Substrate DM3VOGS RN FDA Drug Development and Drug Interactions DM3VOGS RU https://www.fda.gov/drugs/developmentapprovalprocess/developmentresources/druginteractionslabeling/ucm093664.htm#table3-2 DM3VOGS DI DM3VOGS DM3VOGS DN Ceftizoxime DM3VOGS MI DTVP67E DM3VOGS MN Organic anion transporter 3 (SLC22A8) DM3VOGS MT DTP DM3VOGS MA Substrate DM3VOGS RN Human organic anion transporter hOAT3 is a potent transporter of cephalosporin antibiotics, in comparison with hOAT1. Biochem Pharmacol. 2005 Oct 1;70(7):1104-13. DM3VOGS RU http://www.ncbi.nlm.nih.gov/pubmed/16098483 DM9QWAH DI DM9QWAH DM9QWAH DN Ceftolozane/tazobactam DM9QWAH MI TTHI19T DM9QWAH MN Staphylococcus Beta-lactamase (Stap-coc blaZ) DM9QWAH MT DTT DM9QWAH MA Modulator DM9QWAH RN 2014 FDA drug approvals. Nat Rev Drug Discov. 2015 Feb;14(2):77-81. DM9QWAH RU https://pubmed.ncbi.nlm.nih.gov/25633781 DMCEW64 DI DMCEW64 DMCEW64 DN Ceftriaxone DMCEW64 MI TTJP4SM DMCEW64 MN Bacterial Penicillin binding protein (Bact PBP) DMCEW64 MT DTT DMCEW64 MA Modulator DMCEW64 RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. DMCEW64 RU https://www.fda.gov/ DMCEW64 DI DMCEW64 DMCEW64 DN Ceftriaxone DMCEW64 MI DEEAL81 DMCEW64 MN Beta-lactamase (blaB) DMCEW64 MT DME DMCEW64 MA Metabolism DMCEW64 RN Antibiotic resistance and production of extended-spectrum beta-lactamases amongst Klebsiella spp. from intensive care units in Europe. J Antimicrob Chemother. 1996 Sep;38(3):409-24. DMCEW64 RU https://pubmed.ncbi.nlm.nih.gov/8889716 DMCEW64 DI DMCEW64 DMCEW64 DN Ceftriaxone DMCEW64 MI DEYIEO5 DMCEW64 MN Beta-lactamase (blaB) DMCEW64 MT DME DMCEW64 MA Metabolism DMCEW64 RN Determination of the antibiotic resistance rates of Serratia marcescens isolates obtained from various clinical specimens. Niger J Clin Pract. 2019 Jan;22(1):125-130. DMCEW64 RU https://pubmed.ncbi.nlm.nih.gov/30666031 DMCEW64 DI DMCEW64 DMCEW64 DN Ceftriaxone DMCEW64 MI DEBKS91 DMCEW64 MN Beta-lactamase (blaB) DMCEW64 MT DME DMCEW64 MA Metabolism DMCEW64 RN Drug-resistant genes carried by Acinetobacter baumanii isolated from patients with lower respiratory tract infection. Chin Med J (Engl). 2010 Sep;123(18):2571-5. DMCEW64 RU https://pubmed.ncbi.nlm.nih.gov/21034630 DMCEW64 DI DMCEW64 DMCEW64 DN Ceftriaxone DMCEW64 MI DTFI42L DMCEW64 MN Multidrug resistance-associated protein 2 (ABCC2) DMCEW64 MT DTP DMCEW64 MA Substrate DMCEW64 RN Mammalian drug efflux transporters of the ATP binding cassette (ABC) family in multidrug resistance: A review of the past decade. Cancer Lett. 2016 Jan 1;370(1):153-64. DMCEW64 RU http://www.ncbi.nlm.nih.gov/pubmed/26499806 DMCEW64 DI DMCEW64 DMCEW64 DN Ceftriaxone DMCEW64 MI DT9C1TS DMCEW64 MN Organic anion transporting polypeptide 1B3 (SLCO1B3) DMCEW64 MT DTP DMCEW64 MA Substrate DMCEW64 RN Screening of antibiotics that interact with organic anion-transporting polypeptides 1B1 and 1B3 using fluorescent probes. Biol Pharm Bull. 2011;34(3):389-95. DMCEW64 RU http://www.ncbi.nlm.nih.gov/pubmed/21372390 DMCEW64 DI DMCEW64 DMCEW64 DN Ceftriaxone DMCEW64 MI DT9G7XN DMCEW64 MN Peptide transporter 1 (SLC15A1) DMCEW64 MT DTP DMCEW64 MA Substrate DMCEW64 RN Intestinal transport of beta-lactam antibiotics: analysis of the affinity at the H+/peptide symporter (PEPT1), the uptake into Caco-2 cell monolayers and the transepithelial flux. Pharm Res. 1999 Jan;16(1):55-61. DMCEW64 RU https://doi.org/10.1023/A:1018814627484 DMCEW64 DI DMCEW64 DMCEW64 DN Ceftriaxone DMCEW64 MI DTUGYRD DMCEW64 MN P-glycoprotein 1 (ABCB1) DMCEW64 MT DTP DMCEW64 MA Substrate DMCEW64 RN Mammalian drug efflux transporters of the ATP binding cassette (ABC) family in multidrug resistance: A review of the past decade. Cancer Lett. 2016 Jan 1;370(1):153-64. DMCEW64 RU http://www.ncbi.nlm.nih.gov/pubmed/26499806 DMSIMD8 DI DMSIMD8 DMSIMD8 DN Cefuroxime DMSIMD8 MI TTJP4SM DMSIMD8 MN Bacterial Penicillin binding protein (Bact PBP) DMSIMD8 MT DTT DMSIMD8 MA Binder DMSIMD8 RN Cefuroxime resistance in non-beta-lactamase Haemophilus influenzae is linked to mutations in ftsI. J Antimicrob Chemother. 2003 Mar;51(3):523-30. DMSIMD8 RU https://pubmed.ncbi.nlm.nih.gov/12615852 DM4CHN0 DI DM4CHN0 DM4CHN0 DN Cefuroxime axetil DM4CHN0 MI DT9G7XN DM4CHN0 MN Peptide transporter 1 (SLC15A1) DM4CHN0 MT DTP DM4CHN0 MA Substrate DM4CHN0 RN Intestinal transport of beta-lactam antibiotics: analysis of the affinity at the H+/peptide symporter (PEPT1), the uptake into Caco-2 cell monolayers and the transepithelial flux. Pharm Res. 1999 Jan;16(1):55-61. DM4CHN0 RU https://doi.org/10.1023/A:1018814627484 DM6LOQU DI DM6LOQU DM6LOQU DN Celecoxib DM6LOQU MI DES5XRU DM6LOQU MN Cytochrome P450 2C8 (CYP2C8) DM6LOQU MT DME DM6LOQU MA Metabolism DM6LOQU RN Cytochrome P450 2C8 pharmacogenetics: a review of clinical studies. Pharmacogenomics. 2009 Sep;10(9):1489-510. DM6LOQU RU https://www.ncbi.nlm.nih.gov/pubmed/?term=19761371 DM6LOQU DI DM6LOQU DM6LOQU DN Celecoxib DM6LOQU MI DE5IED8 DM6LOQU MN Cytochrome P450 2C9 (CYP2C9) DM6LOQU MT DME DM6LOQU MA Metabolism DM6LOQU RN Drug interactions in dentistry: the importance of knowing your CYPs. J Am Dent Assoc. 2004 Mar;135(3):298-311. DM6LOQU RU https://www.ncbi.nlm.nih.gov/pubmed/?term=15058617 DM6LOQU DI DM6LOQU DM6LOQU DN Celecoxib DM6LOQU MI DECB0K3 DM6LOQU MN Cytochrome P450 2D6 (CYP2D6) DM6LOQU MT DME DM6LOQU MA Metabolism DM6LOQU RN Celecoxib is a substrate of CYP2D6: impact on celecoxib metabolism in individuals with CYP2C9*3 variants. Drug Metab Pharmacokinet. 2018 Oct;33(5):219-227. DM6LOQU RU https://www.ncbi.nlm.nih.gov/pubmed/?term=30219715 DM6LOQU DI DM6LOQU DM6LOQU DN Celecoxib DM6LOQU MI DE4LYSA DM6LOQU MN Cytochrome P450 3A4 (CYP3A4) DM6LOQU MT DME DM6LOQU MA Metabolism DM6LOQU RN Major role of human liver microsomal cytochrome P450 2C9 (CYP2C9) in the oxidative metabolism of celecoxib, a novel cyclooxygenase-II inhibitor. J Pharmacol Exp Ther. 2000 May;293(2):453-9. DM6LOQU RU https://www.ncbi.nlm.nih.gov/pubmed/?term=10773015 DM6LOQU DI DM6LOQU DM6LOQU DN Celecoxib DM6LOQU MI TTVKILB DM6LOQU MN Prostaglandin G/H synthase 2 (COX-2) DM6LOQU MT DTT DM6LOQU MA Inhibitor DM6LOQU RN Pfizer. Product Development Pipeline. March 31 2009. DM6LOQU RU http://media.pfizer.com/files/research/pipeline/2009_0331/pipeline_2009_0331.pdf DM6LOQU DI DM6LOQU DM6LOQU DN Celecoxib DM6LOQU MI DEYWLRK DM6LOQU MN Sulfotransferase 1A1 (SULT1A1) DM6LOQU MT DME DM6LOQU MA Metabolism DM6LOQU RN Sulfonation of 17beta-estradiol and inhibition of sulfotransferase activity by polychlorobiphenylols and celecoxib in channel catfish, Ictalurus punctatus. Aquat Toxicol. 2007 Mar 10;81(3):286-92. DM6LOQU RU https://www.ncbi.nlm.nih.gov/pubmed/?term=17239972 DMD5LBX DI DMD5LBX DMD5LBX DN Celiprolol HCL DMD5LBX MI TTVIREA DMD5LBX MN Adrenergic receptor (ADR) DMD5LBX MT DTT DMD5LBX MA Modulator DMD5LBX RN Natural products as sources of new drugs over the last 25 years. J Nat Prod. 2007 Mar;70(3):461-77. DMD5LBX RU https://pubmed.ncbi.nlm.nih.gov/17309302 DMD5LBX DI DMD5LBX DMD5LBX DN Celiprolol HCL DMD5LBX MI DTE2B1D DMD5LBX MN Organic anion transporting polypeptide 1A2 (SLCO1A2) DMD5LBX MT DTP DMD5LBX MA Substrate DMD5LBX RN Involvement of influx and efflux transport systems in gastrointestinal absorption of celiprolol. J Pharm Sci. 2009 Jul;98(7):2529-39. DMD5LBX RU http://www.ncbi.nlm.nih.gov/pubmed/19067419 DMD5LBX DI DMD5LBX DMD5LBX DN Celiprolol HCL DMD5LBX MI DTUGYRD DMD5LBX MN P-glycoprotein 1 (ABCB1) DMD5LBX MT DTP DMD5LBX MA Substrate DMD5LBX RN Relationship between urinary sodium excretion and pioglitazone-induced edema. J Diabetes Investig. 2010 Oct 19;1(5):208-11. DMD5LBX RU https://doi.org/10.1111/j.2042-7158.1996.tb05904.x DMYT2FP DI DMYT2FP DMYT2FP DN Cellulose Sodium Phosphate DMYT2FP MI TT8X5NO DMYT2FP MN Calcium (Ca) DMYT2FP MT DTT DMYT2FP MA Modulator DMYT2FP RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. DMYT2FP RU https://www.fda.gov/ DMTIUFA DI DMTIUFA DMTIUFA DN Celtura DMTIUFA MI TT3J5ZI DMTIUFA MN Cell mediated immunity response (CMIR) DMTIUFA MT DTT DMTIUFA RN A prospective observational safety study on MF59( ) adjuvanted cell culture-derived vaccine, Celtura( ) during the A/H1N1 (2009) influenza pandemic. Vaccine. 2012 Oct 5;30(45):6436-43. DMTIUFA RU https://pubmed.ncbi.nlm.nih.gov/22902681 DMKMJHE DI DMKMJHE DMKMJHE DN Cemiplimab DMKMJHE MI TTNBFWK DMKMJHE MN Programmed cell death protein 1 (PD-1) DMKMJHE MT DTT DMKMJHE MA Modulator DMKMJHE RN 2018 FDA drug approvals.Nat Rev Drug Discov. 2019 Feb;18(2):85-89. DMKMJHE RU https://pubmed.ncbi.nlm.nih.gov/30710142 DM8Y2RU DI DM8Y2RU DM8Y2RU DN Cenegermin DM8Y2RU MI TTEDJN4 DM8Y2RU MN Low-affinity nerve growth factor receptor (NGFR) DM8Y2RU MT DTT DM8Y2RU MA Agonist DM8Y2RU RN 2018 FDA drug approvals.Nat Rev Drug Discov. 2019 Feb;18(2):85-89. DM8Y2RU RU https://pubmed.ncbi.nlm.nih.gov/30710142 DMXQS7K DI DMXQS7K DMXQS7K DN Cenestin DMXQS7K MI TTZAYWL DMXQS7K MN Estrogen receptor (ESR) DMXQS7K MT DTT DMXQS7K MA Agonist DMXQS7K RN Estrogen replacement therapy and cardioprotection: mechanisms and controversies. Braz J Med Biol Res. 2002 Mar;35(3):271-6. DMXQS7K RU https://pubmed.ncbi.nlm.nih.gov/11887204 DM8KLU9 DI DM8KLU9 DM8KLU9 DN Cenobamate DM8KLU9 MI DEJVYAZ DM8KLU9 MN Cytochrome P450 2A6 (CYP2A6) DM8KLU9 MT DME DM8KLU9 MA Metabolism DM8KLU9 RN FDA label of Cenobamate. The 2020 official website of the U.S. Food and Drug Administration. DM8KLU9 RU https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/212839s000lbl.pdf DM8KLU9 DI DM8KLU9 DM8KLU9 DN Cenobamate DM8KLU9 MI DEPKLMQ DM8KLU9 MN Cytochrome P450 2B6 (CYP2B6) DM8KLU9 MT DME DM8KLU9 MA Metabolism DM8KLU9 RN FDA label of Cenobamate. The 2020 official website of the U.S. Food and Drug Administration. DM8KLU9 RU https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/212839s000lbl.pdf DM8KLU9 DI DM8KLU9 DM8KLU9 DN Cenobamate DM8KLU9 MI DEVDYN7 DM8KLU9 MN Cytochrome P450 2E1 (CYP2E1) DM8KLU9 MT DME DM8KLU9 MA Metabolism DM8KLU9 RN FDA label of Cenobamate. The 2020 official website of the U.S. Food and Drug Administration. DM8KLU9 RU https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/212839s000lbl.pdf DM8KLU9 DI DM8KLU9 DM8KLU9 DN Cenobamate DM8KLU9 MI DE4LYSA DM8KLU9 MN Cytochrome P450 3A4 (CYP3A4) DM8KLU9 MT DME DM8KLU9 MA Metabolism DM8KLU9 RN FDA label of Cenobamate. The 2020 official website of the U.S. Food and Drug Administration. DM8KLU9 RU https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/212839s000lbl.pdf DM8KLU9 DI DM8KLU9 DM8KLU9 DN Cenobamate DM8KLU9 MI DEIBDNY DM8KLU9 MN Cytochrome P450 3A5 (CYP3A5) DM8KLU9 MT DME DM8KLU9 MA Metabolism DM8KLU9 RN FDA label of Cenobamate. The 2020 official website of the U.S. Food and Drug Administration. DM8KLU9 RU https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/212839s000lbl.pdf DM8KLU9 DI DM8KLU9 DM8KLU9 DN Cenobamate DM8KLU9 MI DEGTFWK DM8KLU9 MN Mephenytoin 4-hydroxylase (CYP2C19) DM8KLU9 MT DME DM8KLU9 MA Metabolism DM8KLU9 RN FDA label of Cenobamate. The 2020 official website of the U.S. Food and Drug Administration. DM8KLU9 RU https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/212839s000lbl.pdf DM8KLU9 DI DM8KLU9 DM8KLU9 DN Cenobamate DM8KLU9 MI DEB3CV1 DM8KLU9 MN UDP-glucuronosyltransferase 2B7 (UGT2B7) DM8KLU9 MT DME DM8KLU9 MA Metabolism DM8KLU9 RN FDA label of Cenobamate. The 2020 official website of the U.S. Food and Drug Administration. DM8KLU9 RU https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/212839s000lbl.pdf DMGOVHA DI DMGOVHA DMGOVHA DN Cenobamate DMGOVHA MI TTIG65Q DMGOVHA MN Voltage-gated sodium channel (Nav) DMGOVHA MT DTT DMGOVHA MA Inhibitor DMGOVHA RN Effects of cenobamate (YKP3089), a newly developed anti-epileptic drug, on voltage-gated sodium channels in rat hippocampal CA3 neurons. Eur J Pharmacol. 2019 Jul 15;855:175-182. DMGOVHA RU https://pubmed.ncbi.nlm.nih.gov/31063770 DMD5JU8 DI DMD5JU8 DMD5JU8 DN Cephalexin DMD5JU8 MI TTJP4SM DMD5JU8 MN Bacterial Penicillin binding protein (Bact PBP) DMD5JU8 MT DTT DMD5JU8 MA Binder DMD5JU8 RN Relationship between penicillin-binding protein patterns and beta-lactamases in clinical isolates of Bacteroides fragilis with different susceptibility to beta-lactam antibiotics. J Med Microbiol. 2004 Mar;53(Pt 3):213-21. DMD5JU8 RU https://pubmed.ncbi.nlm.nih.gov/14970246 DMD5JU8 DI DMD5JU8 DMD5JU8 DN Cephalexin DMD5JU8 MI DECB0K3 DMD5JU8 MN Cytochrome P450 2D6 (CYP2D6) DMD5JU8 MT DME DMD5JU8 MA Metabolism DMD5JU8 RN Population pharmacokinetic analysis of mirtazapine. Eur J Clin Pharmacol. 2004 Sep;60(7):473-80. DMD5JU8 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=15289959 DMD5JU8 DI DMD5JU8 DMD5JU8 DN Cephalexin DMD5JU8 MI DE4LYSA DMD5JU8 MN Cytochrome P450 3A4 (CYP3A4) DMD5JU8 MT DME DMD5JU8 MA Metabolism DMD5JU8 RN Transport and metabolic characterization of Caco-2 cells expressing CYP3A4 and CYP3A4 plus oxidoreductase. Pharm Res. 1999 Sep;16(9):1352-9. DMD5JU8 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=10496649 DMD5JU8 DI DMD5JU8 DMD5JU8 DN Cephalexin DMD5JU8 MI DTZGT0P DMD5JU8 MN Multidrug and toxin extrusion protein 1 (SLC47A1) DMD5JU8 MT DTP DMD5JU8 MA Substrate DMD5JU8 RN Reduced renal clearance of a zwitterionic substrate cephalexin in MATE1-deficient mice. J Pharmacol Exp Ther. 2010 Aug;334(2):651-6. DMD5JU8 RU http://www.ncbi.nlm.nih.gov/pubmed/20484555 DMD5JU8 DI DMD5JU8 DMD5JU8 DN Cephalexin DMD5JU8 MI DEIU0XN DMD5JU8 MN N-acylhomoserine lactone acylase (lacA) DMD5JU8 MT DME DMD5JU8 MA Metabolism DMD5JU8 RN A novel quorum-quenching N-acylhomoserine lactone acylase from Acidovorax sp. strain MR-S7 mediates antibiotic resistance. Appl Environ Microbiol. 2017 Jun 16;83(13). pii: e00080-17. DMD5JU8 RU https://pubmed.ncbi.nlm.nih.gov/28455333 DMD5JU8 DI DMD5JU8 DMD5JU8 DN Cephalexin DMD5JU8 MI DT9G7XN DMD5JU8 MN Peptide transporter 1 (SLC15A1) DMD5JU8 MT DTP DMD5JU8 MA Substrate DMD5JU8 RN Direct evidence for efficient transport and minimal metabolism of L-cephalexin by oligopeptide transporter 1 in budded baculovirus fraction. Biol Pharm Bull. 2009 Aug;32(8):1459-61. DMD5JU8 RU http://www.ncbi.nlm.nih.gov/pubmed/19652390 DMD5JU8 DI DMD5JU8 DMD5JU8 DN Cephalexin DMD5JU8 MI DT8QKNP DMD5JU8 MN Peptide transporter 2 (SLC15A2) DMD5JU8 MT DTP DMD5JU8 MA Substrate DMD5JU8 RN Transport characteristics of a novel peptide transporter 1 substrate, antihypotensive drug midodrine, and its amino acid derivatives. J Pharmacol Exp Ther. 2006 Jul;318(1):455-60. DMD5JU8 RU http://www.ncbi.nlm.nih.gov/pubmed/16597710 DMYZITL DI DMYZITL DMYZITL DN Cephaloglycin DMYZITL MI TTJP4SM DMYZITL MN Bacterial Penicillin binding protein (Bact PBP) DMYZITL MT DTT DMYZITL MA Modulator DMYZITL RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. DMYZITL RU https://www.fda.gov/ DMYZITL DI DMYZITL DMYZITL DN Cephaloglycin DMYZITL MI DT9G7XN DMYZITL MN Peptide transporter 1 (SLC15A1) DMYZITL MT DTP DMYZITL MA Substrate DMYZITL RN Pharmaceutical and pharmacological importance of peptide transporters. J Pharm Pharmacol. 2008 May;60(5):543-85. DMYZITL RU https://doi.org/10.1211/jpp.60.5.0002 DM79XDW DI DM79XDW DM79XDW DN Cephalosporin DM79XDW MI TTLP6GN DM79XDW MN Bacterial DD-carboxypeptidase (Bact vanYB) DM79XDW MT DTT DM79XDW MA Binder DM79XDW RN A 1.2-A snapshot of the final step of bacterial cell wall biosynthesis. Proc Natl Acad Sci U S A. 2001 Feb 13;98(4):1427-31. DM79XDW RU https://pubmed.ncbi.nlm.nih.gov/11171967 DM79XDW DI DM79XDW DM79XDW DN Cephalosporin DM79XDW MI DESIWFO DM79XDW MN Beta-lactamase (blaB) DM79XDW MT DME DM79XDW MA Metabolism DM79XDW RN EBR-1, a novel Ambler subclass B1 beta-lactamase from Empedobacter brevis. Antimicrob Agents Chemother. 2002 Oct;46(10):3223-7. DM79XDW RU https://pubmed.ncbi.nlm.nih.gov/12234848 DM51Z9E DI DM51Z9E DM51Z9E DN Cephalothin sodium DM51Z9E MI TTJP4SM DM51Z9E MN Bacterial Penicillin binding protein (Bact PBP) DM51Z9E MT DTT DM51Z9E MA Modulator DM51Z9E RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. DM51Z9E RU https://www.fda.gov/ DM51Z9E DI DM51Z9E DM51Z9E DN Cephalothin sodium DM51Z9E MI DTI7UX6 DM51Z9E MN Breast cancer resistance protein (ABCG2) DM51Z9E MT DTP DM51Z9E MA Substrate DM51Z9E RN Arginine-482 is not essential for transport of antibiotics, primary bile acids and unconjugated sterols by the human breast cancer resistance protein (ABCG2). Biochem J. 2005 Jan 15;385(Pt 2):419-26. DM51Z9E RU https://doi.org/10.1042/BJ20040791 DMV2JNY DI DMV2JNY DMV2JNY DN Cephapirin DMV2JNY MI TTJP4SM DMV2JNY MN Bacterial Penicillin binding protein (Bact PBP) DMV2JNY MT DTT DMV2JNY MA Binder DMV2JNY RN The formation of functional penicillin-binding proteins. J Biol Chem. 1975 Aug 25;250(16):6578-85. DMV2JNY RU https://pubmed.ncbi.nlm.nih.gov/808545 DM9Y5JB DI DM9Y5JB DM9Y5JB DN Cepharanthine DM9Y5JB MI DTUGYRD DM9Y5JB MN P-glycoprotein 1 (ABCB1) DM9Y5JB MT DTP DM9Y5JB MA Substrate DM9Y5JB RN Cepharanthin, a multidrug resistant modifier, is a substrate for P-glycoprotein. J Pharmacol Exp Ther. 1995 Oct;275(1):73-8. DM9Y5JB RU http://jpet.aspetjournals.org/content/275/1/73.long DMB920Z DI DMB920Z DMB920Z DN Ceritinib DMB920Z MI TTPMQSO DMB920Z MN ALK tyrosine kinase receptor (ALK) DMB920Z MT DTT DMB920Z MA Modulator DMB920Z RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7397). DMB920Z RU http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=7397 DMB920Z DI DMB920Z DMB920Z DN Ceritinib DMB920Z MI DTUGYRD DMB920Z MN P-glycoprotein 1 (ABCB1) DMB920Z MT DTP DMB920Z MA Substrate DMB920Z RN P-glycoprotein Mediates Ceritinib Resistance in Anaplastic Lymphoma Kinase-rearranged Non-small Cell Lung Cancer. EBioMedicine. 2015 Dec 12;3:54-66. DMB920Z RU http://www.ncbi.nlm.nih.gov/pubmed/26870817 DMXCM7H DI DMXCM7H DMXCM7H DN Cerivastatin DMXCM7H MI DTI7UX6 DMXCM7H MN Breast cancer resistance protein (ABCG2) DMXCM7H MT DTP DMXCM7H MA Substrate DMXCM7H RN Mammalian drug efflux transporters of the ATP binding cassette (ABC) family in multidrug resistance: A review of the past decade. Cancer Lett. 2016 Jan 1;370(1):153-64. DMXCM7H RU http://www.ncbi.nlm.nih.gov/pubmed/26499806 DMXCM7H DI DMXCM7H DMXCM7H DN Cerivastatin DMXCM7H MI DES5XRU DMXCM7H MN Cytochrome P450 2C8 (CYP2C8) DMXCM7H MT DME DMXCM7H MA Metabolism DMXCM7H RN Role of cytochrome P450 2C8 in drug metabolism and interactions. Pharmacol Rev. 2016 Jan;68(1):168-241. DMXCM7H RU https://www.ncbi.nlm.nih.gov/pubmed/?term=26721703 DMXCM7H DI DMXCM7H DMXCM7H DN Cerivastatin DMXCM7H MI DE4LYSA DMXCM7H MN Cytochrome P450 3A4 (CYP3A4) DMXCM7H MT DME DMXCM7H MA Metabolism DMXCM7H RN Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. DMXCM7H RU https://www.ncbi.nlm.nih.gov/pubmed/?term=19515014 DMXCM7H DI DMXCM7H DMXCM7H DN Cerivastatin DMXCM7H MI DEIBDNY DMXCM7H MN Cytochrome P450 3A5 (CYP3A5) DMXCM7H MT DME DMXCM7H MA Metabolism DMXCM7H RN Drug Interactions Flockhart Table DMXCM7H RU https://drug-interactions.medicine.iu.edu/Main-Table.aspx DMXCM7H DI DMXCM7H DMXCM7H DN Cerivastatin DMXCM7H MI DERD86B DMXCM7H MN Cytochrome P450 3A7 (CYP3A7) DMXCM7H MT DME DMXCM7H MA Metabolism DMXCM7H RN Drug Interactions Flockhart Table DMXCM7H RU https://drug-interactions.medicine.iu.edu/Main-Table.aspx DMXCM7H DI DMXCM7H DMXCM7H DN Cerivastatin DMXCM7H MI TTPADOQ DMXCM7H MN HMG-CoA reductase (HMGCR) DMXCM7H MT DTT DMXCM7H MA Inhibitor DMXCM7H RN Emerging therapies for multiple myeloma. Expert Opin Emerg Drugs. 2009 Mar;14(1):99-127. DMXCM7H RU https://pubmed.ncbi.nlm.nih.gov/19249983 DMXCM7H DI DMXCM7H DMXCM7H DN Cerivastatin DMXCM7H MI DTFI42L DMXCM7H MN Multidrug resistance-associated protein 2 (ABCC2) DMXCM7H MT DTP DMXCM7H MA Substrate DMXCM7H RN Identification of the hepatic efflux transporters of organic anions using double-transfected Madin-Darby canine kidney II cells expressing human organic anion-transporting polypeptide 1B1 (OATP1B1)/multidrug resistance-associated protein 2, OATP1B1/multidrug resistance 1, and OATP1B1/breast cancer resistance protein. J Pharmacol Exp Ther. 2005 Sep;314(3):1059-67. DMXCM7H RU https://doi.org/10.1124/jpet.105.085589 DMXCM7H DI DMXCM7H DMXCM7H DN Cerivastatin DMXCM7H MI DT3D8F0 DMXCM7H MN Organic anion transporting polypeptide 1B1 (SLCO1B1) DMXCM7H MT DTP DMXCM7H MA Substrate DMXCM7H RN FDA Drug Development and Drug Interactions DMXCM7H RU https://www.fda.gov/drugs/developmentapprovalprocess/developmentresources/druginteractionslabeling/ucm093664.htm#table3-2 DMXCM7H DI DMXCM7H DMXCM7H DN Cerivastatin DMXCM7H MI DT9C1TS DMXCM7H MN Organic anion transporting polypeptide 1B3 (SLCO1B3) DMXCM7H MT DTP DMXCM7H MA Substrate DMXCM7H RN FDA Drug Development and Drug Interactions DMXCM7H RU https://www.fda.gov/drugs/developmentapprovalprocess/developmentresources/druginteractionslabeling/ucm093664.htm#table3-2 DMXCM7H DI DMXCM7H DMXCM7H DN Cerivastatin DMXCM7H MI DTPFTEQ DMXCM7H MN Organic anion transporting polypeptide 2B1 (SLCO2B1) DMXCM7H MT DTP DMXCM7H MA Substrate DMXCM7H RN pH-sensitive interaction of HMG-CoA reductase inhibitors (statins) with organic anion transporting polypeptide 2B1. Mol Pharm. 2011 Aug 1;8(4):1303-13. DMXCM7H RU https://doi.org/10.1021/mp200103h DMXCM7H DI DMXCM7H DMXCM7H DN Cerivastatin DMXCM7H MI DTUGYRD DMXCM7H MN P-glycoprotein 1 (ABCB1) DMXCM7H MT DTP DMXCM7H MA Substrate DMXCM7H RN Identification of the hepatic efflux transporters of organic anions using double-transfected Madin-Darby canine kidney II cells expressing human organic anion-transporting polypeptide 1B1 (OATP1B1)/multidrug resistance-associated protein 2, OATP1B1/multidrug resistance 1, and OATP1B1/breast cancer resistance protein. J Pharmacol Exp Ther. 2005 Sep;314(3):1059-67. DMXCM7H RU https://doi.org/10.1124/jpet.105.085589 DMXCM7H DI DMXCM7H DMXCM7H DN Cerivastatin DMXCM7H MI DT56EKP DMXCM7H MN Sodium/taurocholate cotransporting polypeptide (SLC10A1) DMXCM7H MT DTP DMXCM7H MA Substrate DMXCM7H RN Differential effect of genetic variants of Na(+)-taurocholate co-transporting polypeptide (NTCP) and organic anion-transporting polypeptide 1B1 (OATP1B1) on the uptake of HMG-CoA reductase inhibitors. Xenobiotica. 2011 Jan;41(1):24-34. DMXCM7H RU http://www.ncbi.nlm.nih.gov/pubmed/20946088 DMXCM7H DI DMXCM7H DMXCM7H DN Cerivastatin DMXCM7H MI DEYGVN4 DMXCM7H MN UDP-glucuronosyltransferase 1A1 (UGT1A1) DMXCM7H MT DME DMXCM7H MA Metabolism DMXCM7H RN Cerivastatin, genetic variants, and the risk of rhabdomyolysis. Pharmacogenet Genomics. 2011 May;21(5):280-8. DMXCM7H RU https://www.ncbi.nlm.nih.gov/pubmed/21386754 DMXCM7H DI DMXCM7H DMXCM7H DN Cerivastatin DMXCM7H MI DEF2WXN DMXCM7H MN UDP-glucuronosyltransferase 1A3 (UGT1A3) DMXCM7H MT DME DMXCM7H MA Metabolism DMXCM7H RN Cerivastatin, genetic variants, and the risk of rhabdomyolysis. Pharmacogenet Genomics. 2011 May;21(5):280-8. DMXCM7H RU https://www.ncbi.nlm.nih.gov/pubmed/21386754 DM0HAC8 DI DM0HAC8 DM0HAC8 DN Cerliponase Alfa DM0HAC8 MI TTOVYPT DM0HAC8 MN Tripeptidyl-peptidase I (TPP1) DM0HAC8 MT DTT DM0HAC8 MA Modulator DM0HAC8 RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. DM0HAC8 RU https://www.fda.gov/ DM5CL9Z DI DM5CL9Z DM5CL9Z DN Certolizumab DM5CL9Z MI TTF8CQI DM5CL9Z MN Tumor necrosis factor (TNF) DM5CL9Z MT DTT DM5CL9Z MA Inhibitor DM5CL9Z RN Emerging drugs for rheumatoid arthritis. Expert Opin Emerg Drugs. 2008 Mar;13(1):175-96. DM5CL9Z RU https://pubmed.ncbi.nlm.nih.gov/18321156 DMUR94J DI DMUR94J DMUR94J DN Certoparin sodium DMUR94J MI TTCIHJA DMUR94J MN Coagulation factor Xa (F10) DMUR94J MT DTT DMUR94J MA Modulator DMUR94J RN Natural products as sources of new drugs over the last 25 years. J Nat Prod. 2007 Mar;70(3):461-77. DMUR94J RU https://pubmed.ncbi.nlm.nih.gov/17309302 DM6N4PR DI DM6N4PR DM6N4PR DN Cerulenin DM6N4PR MI TT7AOUD DM6N4PR MN Fatty acid synthase (FASN) DM6N4PR MT DTT DM6N4PR MA Inhibitor DM6N4PR RN Inhibition of fatty acid biosynthesis prevents adipocyte lipotoxicity on human osteoblasts in vitro. J Cell Mol Med. 2010 Apr;14(4):982-91. DM6N4PR RU https://pubmed.ncbi.nlm.nih.gov/19382912 DM2WE5K DI DM2WE5K DM2WE5K DN Ceruletide DM2WE5K MI TTVFO0U DM2WE5K MN Gastrin/cholecystokinin type B receptor (CCKBR) DM2WE5K MT DTT DM2WE5K MA Agonist DM2WE5K RN Comparison of postprandial and ceruletide serum bile acid stimulation in dogs. J Vet Intern Med. 2008 Jul-Aug;22(4):873-8. DM2WE5K RU https://pubmed.ncbi.nlm.nih.gov/18537882 DMOMP9U DI DMOMP9U DMOMP9U DN Cetirizine DMOMP9U MI TTTIBOJ DMOMP9U MN Histamine H1 receptor (H1R) DMOMP9U MT DTT DMOMP9U MA Antagonist DMOMP9U RN Design, synthesis and histamine H1-receptor antagonistic activity of some novel 4-amino-2-(substituted)-5-(substituted) aryl-6-[(substituted aryl) amino] pyrimidines. Arzneimittelforschung. 2009;59(5):243-7. DMOMP9U RU https://pubmed.ncbi.nlm.nih.gov/19537525 DMOMP9U DI DMOMP9U DMOMP9U DN Cetirizine DMOMP9U MI DTUGYRD DMOMP9U MN P-glycoprotein 1 (ABCB1) DMOMP9U MT DTP DMOMP9U MA Substrate DMOMP9U RN Stereoselective and multiple carrier-mediated transport of cetirizine across Caco-2 cell monolayers with potential drug interaction. Chirality. 2010 Jul;22(7):684-92. DMOMP9U RU http://www.ncbi.nlm.nih.gov/pubmed/20014242 DMSP4JX DI DMSP4JX DMSP4JX DN Cetraxate DMSP4JX MI TT5L2VC DMSP4JX MN Kallikrein-related peptidase (KLK) DMSP4JX MT DTT DMSP4JX MA Modulator DMSP4JX RN A new broad spectrum inhibitor of esteroproteases, 4-(2-carboxyethyl) phenyl-trans-4-aminomethyl cyclohexane carboxylate hydrochloride (DV 1006). Tohoku J Exp Med. 1972 Mar;106(3):233-48. DMSP4JX RU https://pubmed.ncbi.nlm.nih.gov/4261023 DMFD9Q6 DI DMFD9Q6 DMFD9Q6 DN Cetrorelix DMFD9Q6 MI TT8R70G DMFD9Q6 MN Gonadotropin-releasing hormone receptor (GNRHR) DMFD9Q6 MT DTT DMFD9Q6 MA Antagonist DMFD9Q6 RN Gonadotropin releasing hormone analogs induce apoptosis by extrinsic pathway involving p53 phosphorylation in primary cell cultures of human prostatic adenocarcinomas. Prostate. 2009 Jul 1;69(10):1025-33. DMFD9Q6 RU https://pubmed.ncbi.nlm.nih.gov/19301301 DMLNCE0 DI DMLNCE0 DMLNCE0 DN Cetuximab DMLNCE0 MI TTGKNB4 DMLNCE0 MN Epidermal growth factor receptor (EGFR) DMLNCE0 MT DTT DMLNCE0 RN Molecular inhibition of angiogenesis and metastatic potential in human squamous cell carcinomas after epidermal growth factor receptor blockade. Mol Cancer Ther. 2002 May;1(7):507-14. DMLNCE0 RU https://pubmed.ncbi.nlm.nih.gov/12479268 DMWSMND DI DMWSMND DMWSMND DN Cevimeline DMWSMND MI DECB0K3 DMWSMND MN Cytochrome P450 2D6 (CYP2D6) DMWSMND MT DME DMWSMND MA Metabolism DMWSMND RN Pharmacokinetics and metabolism of the novel muscarinic receptor agonist SNI-2011 in rats and dogs. Arzneimittelforschung. 2003;53(1):26-33. DMWSMND RU https://www.ncbi.nlm.nih.gov/pubmed/?term=12608011 DMWSMND DI DMWSMND DMWSMND DN Cevimeline DMWSMND MI DE4LYSA DMWSMND MN Cytochrome P450 3A4 (CYP3A4) DMWSMND MT DME DMWSMND MA Metabolism DMWSMND RN Pharmacokinetics and metabolism of the novel muscarinic receptor agonist SNI-2011 in rats and dogs. Arzneimittelforschung. 2003;53(1):26-33. DMWSMND RU https://www.ncbi.nlm.nih.gov/pubmed/?term=12608011 DMWSMND DI DMWSMND DMWSMND DN Cevimeline DMWSMND MI TTQ13Z5 DMWSMND MN Muscarinic acetylcholine receptor M3 (CHRM3) DMWSMND MT DTT DMWSMND MA Agonist DMWSMND RN Degradation of submandibular gland AQP5 by parasympathetic denervation of chorda tympani and its recovery by cevimeline, an M3 muscarinic receptor ... Am J Physiol Gastrointest Liver Physiol. 2008 Jul;295(1):G112-G123. DMWSMND RU https://pubmed.ncbi.nlm.nih.gov/18450949 DMKN345 DI DMKN345 DMKN345 DN Charybdotoxin DMKN345 MI TTMNI76 DMKN345 MN Calcium-activated potassium channel (KCN) DMKN345 MT DTT DMKN345 MA Blocker DMKN345 RN Reversible inhibition of the platelet procoagulant response through manipulation of the Gardos channel. Blood. 2006 Oct 1;108(7):2223-8. DMKN345 RU https://pubmed.ncbi.nlm.nih.gov/16741254 DMQ8JIK DI DMQ8JIK DMQ8JIK DN Chenodiol DMQ8JIK MI DE4LYSA DMQ8JIK MN Cytochrome P450 3A4 (CYP3A4) DMQ8JIK MT DME DMQ8JIK MA Metabolism DMQ8JIK RN Identification of human hepatic cytochrome p450 enzymes involved in the biotransformation of cholic and chenodeoxycholic acid. Drug Metab Dispos. 2008 Oct;36(10):1983-91. DMQ8JIK RU https://www.ncbi.nlm.nih.gov/pubmed/?term=18583509 DMQ8JIK DI DMQ8JIK DMQ8JIK DN Chenodiol DMQ8JIK MI DETL4WB DMQ8JIK MN Cytochrome P450 8B1 (CYP8B1) DMQ8JIK MT DME DMQ8JIK MA Metabolism DMQ8JIK RN Conversion of chenodeoxycholic acid to cholic acid by human CYP8B1. Biol Chem. 2019 Apr 24;400(5):625-628. DMQ8JIK RU https://pubmed.ncbi.nlm.nih.gov/30465713 DMQ8JIK DI DMQ8JIK DMQ8JIK DN Chenodiol DMQ8JIK MI TTS4UGC DMQ8JIK MN Farnesoid X-activated receptor (FXR) DMQ8JIK MT DTT DMQ8JIK MA Modulator DMQ8JIK RN Lithocholic acid decreases expression of bile salt export pump through farnesoid X receptor antagonist activity. J Biol Chem. 2002 Aug 30;277(35):31441-7. DMQ8JIK RU https://pubmed.ncbi.nlm.nih.gov/12052824 DMQ8JIK DI DMQ8JIK DMQ8JIK DN Chenodiol DMQ8JIK MI DEYGVN4 DMQ8JIK MN UDP-glucuronosyltransferase 1A1 (UGT1A1) DMQ8JIK MT DME DMQ8JIK MA Metabolism DMQ8JIK RN Human UDP-glucuronosyltransferase (UGT)1A3 enzyme conjugates chenodeoxycholic acid in the liver. Hepatology. 2006 Nov;44(5):1158-70. DMQ8JIK RU https://www.ncbi.nlm.nih.gov/pubmed/?term=17058234 DMXGJEI DI DMXGJEI DMXGJEI DN Chlophedianol DMXGJEI MI TTTIBOJ DMXGJEI MN Histamine H1 receptor (H1R) DMXGJEI MT DTT DMXGJEI MA Antagonist DMXGJEI RN Identification and differentiation of alkylamine antihistamines and their metabolites in urine by computerized gas chromatography-mass spectrometry. J Chromatogr. 1988 Aug 19;430(1):31-41. DMXGJEI RU https://pubmed.ncbi.nlm.nih.gov/2905706 DMRKE63 DI DMRKE63 DMRKE63 DN Chlorambucil DMRKE63 MI TTABD5E DMRKE63 MN DNA replication (DNA repli) DMRKE63 MT DTT DMRKE63 MA Intercalator DMRKE63 RN Roles of DNA repair and reductase activity in the cytotoxicity of the hypoxia-activated dinitrobenzamide mustard PR-104A. Mol Cancer Ther. 2009 Jun;8(6):1714-23. DMRKE63 RU https://pubmed.ncbi.nlm.nih.gov/19509245 DMRKE63 DI DMRKE63 DMRKE63 DN Chlorambucil DMRKE63 MI DEK6079 DMRKE63 MN Glutathione S-transferase pi (GSTP1) DMRKE63 MT DME DMRKE63 MA Metabolism DMRKE63 RN The anti-cancer drug chlorambucil as a substrate for the human polymorphic enzyme glutathione transferase P1-1: kinetic properties and crystallographic characterisation of allelic variants. J Mol Biol. 2008 Jun 27;380(1):131-44. DMRKE63 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=18511072 DMRKE63 DI DMRKE63 DMRKE63 DN Chlorambucil DMRKE63 MI DTE2B1D DMRKE63 MN Organic anion transporting polypeptide 1A2 (SLCO1A2) DMRKE63 MT DTP DMRKE63 MA Substrate DMRKE63 RN Transporters and renal drug elimination. Annu Rev Pharmacol Toxicol. 2004;44:137-66. DMRKE63 RU https://doi.org/10.1146/annurev.pharmtox.44.101802.121856 DMRKE63 DI DMRKE63 DMRKE63 DN Chlorambucil DMRKE63 MI DTUGYRD DMRKE63 MN P-glycoprotein 1 (ABCB1) DMRKE63 MT DTP DMRKE63 MA Substrate DMRKE63 RN Mammalian drug efflux transporters of the ATP binding cassette (ABC) family in multidrug resistance: A review of the past decade. Cancer Lett. 2016 Jan 1;370(1):153-64. DMRKE63 RU http://www.ncbi.nlm.nih.gov/pubmed/26499806 DMFXEWT DI DMFXEWT DMFXEWT DN Chloramphenicol DMFXEWT MI TTLFGBV DMFXEWT MN Bacterial 23S ribosomal RNA (Bact 23S rRNA) DMFXEWT MT DTT DMFXEWT MA Binder DMFXEWT RN Inhibition of peptide bond formation by pleuromutilins: the structure of the 50S ribosomal subunit from Deinococcus radiodurans in complex with tiamulin. Mol Microbiol. 2004 Dec;54(5):1287-94. DMFXEWT RU https://pubmed.ncbi.nlm.nih.gov/15554968 DMFXEWT DI DMFXEWT DMFXEWT DN Chloramphenicol DMFXEWT MI DE26V9J DMFXEWT MN Chloramphenicolase (chlR) DMFXEWT MT DME DMFXEWT MA Metabolism DMFXEWT RN The bacterial degradation of chloramphenico. Lancet. 1967 Jun 10;1(7502):1259-60. DMFXEWT RU https://pubmed.ncbi.nlm.nih.gov/4165044 DMFXEWT DI DMFXEWT DMFXEWT DN Chloramphenicol DMFXEWT MI DEMUBWL DMFXEWT MN Chloramphenicolase (chlR) DMFXEWT MT DME DMFXEWT MA Metabolism DMFXEWT RN The bacterial degradation of chloramphenico. Lancet. 1967 Jun 10;1(7502):1259-60. DMFXEWT RU https://pubmed.ncbi.nlm.nih.gov/4165044 DMFXEWT DI DMFXEWT DMFXEWT DN Chloramphenicol DMFXEWT MI DECMT89 DMFXEWT MN Chloramphenicolase (chlR) DMFXEWT MT DME DMFXEWT MA Metabolism DMFXEWT RN The bacterial degradation of chloramphenico. Lancet. 1967 Jun 10;1(7502):1259-60. DMFXEWT RU https://pubmed.ncbi.nlm.nih.gov/4165044 DMFXEWT DI DMFXEWT DMFXEWT DN Chloramphenicol DMFXEWT MI DEFVHQU DMFXEWT MN Glycerol-3-phosphate dehydrogenase (gpsA) DMFXEWT MT DME DMFXEWT MA Metabolism DMFXEWT RN Porcine beta-defensin 2 displays broad antimicrobial activity against pathogenic intestinal bacteria. Mol Immunol. 2008 Jan;45(2):386-94. DMFXEWT RU http://www.ncbi.nlm.nih.gov/pubmed/17658606 DMFXEWT DI DMFXEWT DMFXEWT DN Chloramphenicol DMFXEWT MI DEGTFWK DMFXEWT MN Mephenytoin 4-hydroxylase (CYP2C19) DMFXEWT MT DME DMFXEWT MA Metabolism DMFXEWT RN Chloramphenicol is a potent inhibitor of cytochrome P450 isoforms CYP2C19 and CYP3A4 in human liver microsomes. Antimicrob Agents Chemother. 2003 Nov;47(11):3464-9. DMFXEWT RU https://www.ncbi.nlm.nih.gov/pubmed/?term=14576103 DMFXEWT DI DMFXEWT DMFXEWT DN Chloramphenicol DMFXEWT MI DTUGYRD DMFXEWT MN P-glycoprotein 1 (ABCB1) DMFXEWT MT DTP DMFXEWT MA Substrate DMFXEWT RN Active Mediated Transport of Chloramphenicol and Thiamphenicol in a Calu-3 Lung Epithelial Cell Model. J Pharm Sci. 2018 Apr;107(4):1178-1184. DMFXEWT RU http://www.ncbi.nlm.nih.gov/pubmed/29221992 DMTN5XI DI DMTN5XI DMTN5XI DN Chlordiazepoxide DMTN5XI MI TTPTXIN DMTN5XI MN Translocator protein (TSPO) DMTN5XI MT DTT DMTN5XI MA Modulator DMTN5XI RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. DMTN5XI RU https://www.fda.gov/ DMQ9MVG DI DMQ9MVG DMQ9MVG DN Chlorhexidine DMQ9MVG MI TT4ILYC DMQ9MVG MN Bacterial Dihydropteroate synthetase (Bact folP) DMQ9MVG MT DTT DMQ9MVG MA Breaker DMQ9MVG RN The mechanism of action of chlorhexidine. FEMS Microbiol Lett. 1992 Dec 15;79(1-3):211-5. DMQ9MVG RU https://pubmed.ncbi.nlm.nih.gov/1335944 DMSF4PR DI DMSF4PR DMSF4PR DN Chlormerodrin DMSF4PR MI TTJUWVB DMSF4PR MN Succinate-semialdehyde dehydrogenase (ALDH5A1) DMSF4PR MT DTT DMSF4PR MA Modulator DMSF4PR RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. DMSF4PR RU https://www.fda.gov/ DMTWUXR DI DMTWUXR DMTWUXR DN Chlormezanone DMTWUXR MI TTPTXIN DMTWUXR MN Translocator protein (TSPO) DMTWUXR MT DTT DMTWUXR MA Agonist DMTWUXR RN Successful treatment of anxiety with a single night-time dose of chlormezanone: double-blind comparison with diazepam. Curr Med Res Opin. 1982;8(1):33-8. DMTWUXR RU https://pubmed.ncbi.nlm.nih.gov/7105820 DMSOQK1 DI DMSOQK1 DMSOQK1 DN Chloroprocaine DMSOQK1 MI TTWK8D0 DMSOQK1 MN Sodium pump subunit alpha-1 (ATP1A1) DMSOQK1 MT DTT DMSOQK1 MA Blocker DMSOQK1 RN Inhibition of the Na,K-ATPase of canine renal medulla by several local anesthetics. Pharmacol Res. 2001 Apr;43(4):399-403. DMSOQK1 RU https://pubmed.ncbi.nlm.nih.gov/11352545 DMSI5CB DI DMSI5CB DMSI5CB DN Chloroquine DMSI5CB MI DE6OQ3W DMSI5CB MN Cytochrome P450 1A1 (CYP1A1) DMSI5CB MT DME DMSI5CB MA Metabolism DMSI5CB RN In vitro metabolism of chloroquine: identification of CYP2C8, CYP3A4, and CYP2D6 as the main isoforms catalyzing N-desethylchloroquine formation. Drug Metab Dispos. 2003 Jun;31(6):748-54. DMSI5CB RU https://www.ncbi.nlm.nih.gov/pubmed/?term=12756207 DMSI5CB DI DMSI5CB DMSI5CB DN Chloroquine DMSI5CB MI DES5XRU DMSI5CB MN Cytochrome P450 2C8 (CYP2C8) DMSI5CB MT DME DMSI5CB MA Metabolism DMSI5CB RN Short communication: high prevalence of the cytochrome P450 2C8*2 mutation in Northern Ghana. Trop Med Int Health. 2005 Dec;10(12):1271-3. DMSI5CB RU https://www.ncbi.nlm.nih.gov/pubmed/?term=16359408 DMSI5CB DI DMSI5CB DMSI5CB DN Chloroquine DMSI5CB MI DECB0K3 DMSI5CB MN Cytochrome P450 2D6 (CYP2D6) DMSI5CB MT DME DMSI5CB MA Metabolism DMSI5CB RN Halofantrine and chloroquine inhibit CYP2D6 activity in healthy Zambians. Br J Clin Pharmacol. 1998 Mar;45(3):315-7. DMSI5CB RU https://www.ncbi.nlm.nih.gov/pubmed/?term=10896408 DMSI5CB DI DMSI5CB DMSI5CB DN Chloroquine DMSI5CB MI DE4LYSA DMSI5CB MN Cytochrome P450 3A4 (CYP3A4) DMSI5CB MT DME DMSI5CB MA Metabolism DMSI5CB RN Cytochrome P450 2C8 and CYP3A4/5 are involved in chloroquine metabolism in human liver microsomes. Arch Pharm Res. 2003 Aug;26(8):631-7. DMSI5CB RU https://www.ncbi.nlm.nih.gov/pubmed/?term=12967198 DMSI5CB DI DMSI5CB DMSI5CB DN Chloroquine DMSI5CB MI DEIBDNY DMSI5CB MN Cytochrome P450 3A5 (CYP3A5) DMSI5CB MT DME DMSI5CB MA Metabolism DMSI5CB RN Cytochrome P450 2C8 and CYP3A4/5 are involved in chloroquine metabolism in human liver microsomes. Arch Pharm Res. 2003 Aug;26(8):631-7. DMSI5CB RU https://www.ncbi.nlm.nih.gov/pubmed/?term=12967198 DMSI5CB DI DMSI5CB DMSI5CB DN Chloroquine DMSI5CB MI TTKY2NS DMSI5CB MN Duffy antigen chemokine receptor (ACKR1) DMSI5CB MT DTT DMSI5CB MA Modulator DMSI5CB RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. DMSI5CB RU https://www.fda.gov/ DMSI5CB DI DMSI5CB DMSI5CB DN Chloroquine DMSI5CB MI DTZGT0P DMSI5CB MN Multidrug and toxin extrusion protein 1 (SLC47A1) DMSI5CB MT DTP DMSI5CB MA Substrate DMSI5CB RN Molecular mechanism of renal tubular secretion of the antimalarial drug chloroquine. Antimicrob Agents Chemother. 2011 Jul;55(7):3091-8. DMSI5CB RU http://www.ncbi.nlm.nih.gov/pubmed/21518836 DMSI5CB DI DMSI5CB DMSI5CB DN Chloroquine DMSI5CB MI DTUGYRD DMSI5CB MN P-glycoprotein 1 (ABCB1) DMSI5CB MT DTP DMSI5CB MA Substrate DMSI5CB RN Improving the prediction of the brain disposition for orally administered drugs using BDDCS. Adv Drug Deliv Rev. 2012 Jan;64(1):95-109. DMSI5CB RU https://doi.org/10.1016/j.addr.2011.12.008 DMLHESP DI DMLHESP DMLHESP DN Chlorothiazide DMLHESP MI DTI7UX6 DMLHESP MN Breast cancer resistance protein (ABCG2) DMLHESP MT DTP DMLHESP MA Substrate DMLHESP RN ABCG2 modulates chlorothiazide permeability--in vitro-characterization of its interactions. Drug Metab Pharmacokinet. 2012;27(3):349-53. DMLHESP RU https://doi.org/10.2133/dmpk.DMPK-11-NT-068 DMLHESP DI DMLHESP DMLHESP DN Chlorothiazide DMLHESP MI TTANPDJ DMLHESP MN Carbonic anhydrase II (CA-II) DMLHESP MT DTT DMLHESP MA Inhibitor DMLHESP RN Localization of diuretic effects along the loop of Henle: an in vivo microperfusion study in rats. Clin Sci (Lond). 2000 Apr;98(4):481-8. DMLHESP RU https://pubmed.ncbi.nlm.nih.gov/10731484 DMLHESP DI DMLHESP DMLHESP DN Chlorothiazide DMLHESP MI DTVP67E DMLHESP MN Organic anion transporter 3 (SLC22A8) DMLHESP MT DTP DMLHESP MA Substrate DMLHESP RN Overlapping in vitro and in vivo specificities of the organic anion transporters OAT1 and OAT3 for loop and thiazide diuretics. Am J Physiol Renal Physiol. 2008 Apr;294(4):F867-73. DMLHESP RU http://www.ncbi.nlm.nih.gov/pubmed/18216144 DMFZBMQ DI DMFZBMQ DMFZBMQ DN Chloroxine DMFZBMQ MI TTQW87Y DMFZBMQ MN Opioid receptor kappa (OPRK1) DMFZBMQ MT DTT DMFZBMQ MA Inhibitor DMFZBMQ RN In silico identification and biochemical evaluation of novel inhibitors of NRH:quinone oxidoreductase 2 (NQO2). Bioorg Med Chem Lett. 2010 Dec 15;20(24):7331-6. DMFZBMQ RU https://pubmed.ncbi.nlm.nih.gov/21074425 DM5URA2 DI DM5URA2 DM5URA2 DN Chlorpheniramine DM5URA2 MI DECB0K3 DM5URA2 MN Cytochrome P450 2D6 (CYP2D6) DM5URA2 MT DME DM5URA2 MA Metabolism DM5URA2 RN The roles of CYP2D6 and stereoselectivity in the clinical pharmacokinetics of chlorpheniramine. Br J Clin Pharmacol. 2002 May;53(5):519-25. DM5URA2 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=11994058 DM5URA2 DI DM5URA2 DM5URA2 DN Chlorpheniramine DM5URA2 MI DE4LYSA DM5URA2 MN Cytochrome P450 3A4 (CYP3A4) DM5URA2 MT DME DM5URA2 MA Metabolism DM5URA2 RN Drug Interactions Flockhart Table DM5URA2 RU https://drug-interactions.medicine.iu.edu/Main-Table.aspx DM5URA2 DI DM5URA2 DM5URA2 DN Chlorpheniramine DM5URA2 MI DEIBDNY DM5URA2 MN Cytochrome P450 3A5 (CYP3A5) DM5URA2 MT DME DM5URA2 MA Metabolism DM5URA2 RN Drug Interactions Flockhart Table DM5URA2 RU https://drug-interactions.medicine.iu.edu/Main-Table.aspx DM5URA2 DI DM5URA2 DM5URA2 DN Chlorpheniramine DM5URA2 MI DERD86B DM5URA2 MN Cytochrome P450 3A7 (CYP3A7) DM5URA2 MT DME DM5URA2 MA Metabolism DM5URA2 RN Drug Interactions Flockhart Table DM5URA2 RU https://drug-interactions.medicine.iu.edu/Main-Table.aspx DM5URA2 DI DM5URA2 DM5URA2 DN Chlorpheniramine DM5URA2 MI TTTIBOJ DM5URA2 MN Histamine H1 receptor (H1R) DM5URA2 MT DTT DM5URA2 MA Antagonist DM5URA2 RN Intact cell binding for in vitro prediction of sedative and non-sedative histamine H1-receptor antagonists based on receptor internalization. J Pharmacol Sci. 2008 May;107(1):66-79. DM5URA2 RU https://pubmed.ncbi.nlm.nih.gov/18446005 DM5URA2 DI DM5URA2 DM5URA2 DN Chlorpheniramine DM5URA2 MI DTSYQGK DM5URA2 MN Multidrug resistance-associated protein 1 (ABCC1) DM5URA2 MT DTP DM5URA2 MA Substrate DM5URA2 RN Carrier mediated transport of chlorpheniramine and chlorcyclizine across bovine olfactory mucosa: implications on nose-to-brain transport. J Pharm Sci. 2005 Mar;94(3):613-24. DM5URA2 RU http://www.ncbi.nlm.nih.gov/pubmed/15666293 DMQRPOS DI DMQRPOS DMQRPOS DN Chlorphentermine hydrochloride DMQRPOS MI TT3ROYC DMQRPOS MN Serotonin transporter (SERT) DMQRPOS MT DTT DMQRPOS MA Modulator DMQRPOS RN Aminorex, fenfluramine, and chlorphentermine are serotonin transporter substrates.Implications for primary pulmonary hypertension.Circulation.1999 Aug 24;100(8):869-75. DMQRPOS RU https://www.ncbi.nlm.nih.gov/pubmed/10458725 DM1IFGT DI DM1IFGT DM1IFGT DN Chlorproguanil DM1IFGT MI TT9SL3Q DM1IFGT MN Polypeptide deformylase (PDF) DM1IFGT MT DTT DM1IFGT MA Inhibitor DM1IFGT RN The fight against drug-resistant malaria: novel plasmodial targets and antimalarial drugs. Curr Med Chem. 2008;15(2):161-71. DM1IFGT RU https://pubmed.ncbi.nlm.nih.gov/18220771 DMBGZI3 DI DMBGZI3 DMBGZI3 DN Chlorpromazine DMBGZI3 MI DEJGDUW DMBGZI3 MN Cytochrome P450 1A2 (CYP1A2) DMBGZI3 MT DME DMBGZI3 MA Metabolism DMBGZI3 RN Functional polymorphisms of the cytochrome P450 1A2 (CYP1A2) gene and prolonged QTc interval in schizophrenia. Prog Neuropsychopharmacol Biol Psychiatry. 2007 Aug 15;31(6):1297-302. DMBGZI3 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=17611010 DMBGZI3 DI DMBGZI3 DMBGZI3 DN Chlorpromazine DMBGZI3 MI DECB0K3 DMBGZI3 MN Cytochrome P450 2D6 (CYP2D6) DMBGZI3 MT DME DMBGZI3 MA Metabolism DMBGZI3 RN Use of antidepressant drugs in schizophrenic patients with depression. Encephale. 2006 Mar-Apr;32(2 Pt 1):263-9. DMBGZI3 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=16910628 DMBGZI3 DI DMBGZI3 DMBGZI3 DN Chlorpromazine DMBGZI3 MI DE4LYSA DMBGZI3 MN Cytochrome P450 3A4 (CYP3A4) DMBGZI3 MT DME DMBGZI3 MA Metabolism DMBGZI3 RN Effect of classic and atypical neuroleptics on cytochrome P450 3A (CYP3A) in rat liver. Pharmacol Rep. 2012;64(6):1411-8. DMBGZI3 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=23406751 DMBGZI3 DI DMBGZI3 DMBGZI3 DN Chlorpromazine DMBGZI3 MI DEIZLTN DMBGZI3 MN Docosahexaenoic acid omega-hydroxylase (CYP4F11) DMBGZI3 MT DME DMBGZI3 MA Metabolism DMBGZI3 RN Expression and characterization of human cytochrome P450 4F11: putative role in the metabolism of therapeutic drugs and eicosanoids. Toxicol Appl Pharmacol. 2004 Sep 15;199(3):295-304. DMBGZI3 RU https://pubmed.ncbi.nlm.nih.gov/15364545 DMBGZI3 DI DMBGZI3 DMBGZI3 DN Chlorpromazine DMBGZI3 MI TTEX248 DMBGZI3 MN Dopamine D2 receptor (D2R) DMBGZI3 MT DTT DMBGZI3 MA Antagonist DMBGZI3 RN Modulatory role of dopamine D2 receptors and fundamental role of L-type Ca2+ channels in the induction of long-term potentiation in the basolateral... Eur J Pharmacol. 2009 Mar 15;606(1-3):90-3. DMBGZI3 RU https://pubmed.ncbi.nlm.nih.gov/19374860 DMBGZI3 DI DMBGZI3 DMBGZI3 DN Chlorpromazine DMBGZI3 MI DTUGYRD DMBGZI3 MN P-glycoprotein 1 (ABCB1) DMBGZI3 MT DTP DMBGZI3 MA Substrate DMBGZI3 RN Mammalian drug efflux transporters of the ATP binding cassette (ABC) family in multidrug resistance: A review of the past decade. Cancer Lett. 2016 Jan 1;370(1):153-64. DMBGZI3 RU http://www.ncbi.nlm.nih.gov/pubmed/26499806 DMPHZQE DI DMPHZQE DMPHZQE DN Chlorpropamide DMPHZQE MI DE5IED8 DMPHZQE MN Cytochrome P450 2C9 (CYP2C9) DMPHZQE MT DME DMPHZQE MA Metabolism DMPHZQE RN Chlorpropamide 2-hydroxylation is catalysed by CYP2C9 and CYP2C19 in vitro: chlorpropamide disposition is influenced by CYP2C9, but not by CYP2C19 genetic polymorphism. Br J Clin Pharmacol. 2005 May;59(5):552-63. DMPHZQE RU https://www.ncbi.nlm.nih.gov/pubmed/?term=15842554 DMPHZQE DI DMPHZQE DMPHZQE DN Chlorpropamide DMPHZQE MI TTG140O DMPHZQE MN Inward rectifier potassium channel Kir1.2 (KCNJ10) DMPHZQE MT DTT DMPHZQE MA Blocker DMPHZQE RN Effect of the chlorpropamide and fructose-1,6-bisphosphate of soluble TNF receptor II levels. Pharmacol Res. 2004 May;49(5):449-53. DMPHZQE RU https://pubmed.ncbi.nlm.nih.gov/14998554 DMPHZQE DI DMPHZQE DMPHZQE DN Chlorpropamide DMPHZQE MI DEGTFWK DMPHZQE MN Mephenytoin 4-hydroxylase (CYP2C19) DMPHZQE MT DME DMPHZQE MA Metabolism DMPHZQE RN Chlorpropamide 2-hydroxylation is catalysed by CYP2C9 and CYP2C19 in vitro: chlorpropamide disposition is influenced by CYP2C9, but not by CYP2C19 genetic polymorphism. Br J Clin Pharmacol. 2005 May;59(5):552-63. DMPHZQE RU https://www.ncbi.nlm.nih.gov/pubmed/?term=15842554 DMY0KGJ DI DMY0KGJ DMY0KGJ DN Chlorprothixene DMY0KGJ MI TTEX248 DMY0KGJ MN Dopamine D2 receptor (D2R) DMY0KGJ MT DTT DMY0KGJ MA Antagonist DMY0KGJ RN Potential utility of histamine H3 receptor antagonist pharmacophore in antipsychotics. Bioorg Med Chem Lett. 2009 Jan 15;19(2):538-42. DMY0KGJ RU https://pubmed.ncbi.nlm.nih.gov/19091563 DM4DMBT DI DM4DMBT DM4DMBT DN Chlorthalidone DM4DMBT MI TTS087L DM4DMBT MN Solute carrier family 12 member 1 (SLC12A1) DM4DMBT MT DTT DM4DMBT MA Blocker DM4DMBT RN The 45-year story of the development of an anti-aldosterone more specific than spironolactone. Mol Cell Endocrinol. 2004 Mar 31;217(1-2):45-52. DM4DMBT RU https://pubmed.ncbi.nlm.nih.gov/15134800 DMCYVDT DI DMCYVDT DMCYVDT DN Chlorzoxazone DMCYVDT MI TTMNI76 DMCYVDT MN Calcium-activated potassium channel (KCN) DMCYVDT MT DTT DMCYVDT MA Activator DMCYVDT RN Chlorzoxazone inhibits contraction of rat thoracic aorta. Eur J Pharmacol. 2006 Sep 18;545(2-3):161-6. DMCYVDT RU https://pubmed.ncbi.nlm.nih.gov/16859676 DMCYVDT DI DMCYVDT DMCYVDT DN Chlorzoxazone DMCYVDT MI DE4OGUF DMCYVDT MN Cytochrome P450 102A1 (cyp102) DMCYVDT MT DME DMCYVDT MA Metabolism DMCYVDT RN Wild-type CYP102A1 as a biocatalyst: turnover of drugs usually metabolised by human liver enzymes. J Biol Inorg Chem. 2007 Mar;12(3):313-23. DMCYVDT RU https://pubmed.ncbi.nlm.nih.gov/17235582 DMCYVDT DI DMCYVDT DMCYVDT DN Chlorzoxazone DMCYVDT MI DEJGDUW DMCYVDT MN Cytochrome P450 1A2 (CYP1A2) DMCYVDT MT DME DMCYVDT MA Metabolism DMCYVDT RN Inhibitory monoclonal antibodies to human cytochrome P450 1A2: analysis of phenacetin O-deethylation in human liver. Pharmacogenetics. 1998 Oct;8(5):375-82. DMCYVDT RU https://www.ncbi.nlm.nih.gov/pubmed/?term=9825829 DMCYVDT DI DMCYVDT DMCYVDT DN Chlorzoxazone DMCYVDT MI DEJVYAZ DMCYVDT MN Cytochrome P450 2A6 (CYP2A6) DMCYVDT MT DME DMCYVDT MA Metabolism DMCYVDT RN Prediction of human liver microsomal oxidations of 7-ethoxycoumarin and chlorzoxazone with kinetic parameters of recombinant cytochrome P-450 enzymes. Drug Metab Dispos. 1999 Nov;27(11):1274-80. DMCYVDT RU https://www.ncbi.nlm.nih.gov/pubmed/?term=10534312 DMCYVDT DI DMCYVDT DMCYVDT DN Chlorzoxazone DMCYVDT MI DECB0K3 DMCYVDT MN Cytochrome P450 2D6 (CYP2D6) DMCYVDT MT DME DMCYVDT MA Metabolism DMCYVDT RN Prediction of human liver microsomal oxidations of 7-ethoxycoumarin and chlorzoxazone with kinetic parameters of recombinant cytochrome P-450 enzymes. Drug Metab Dispos. 1999 Nov;27(11):1274-80. DMCYVDT RU https://www.ncbi.nlm.nih.gov/pubmed/?term=10534312 DMCYVDT DI DMCYVDT DMCYVDT DN Chlorzoxazone DMCYVDT MI DEVDYN7 DMCYVDT MN Cytochrome P450 2E1 (CYP2E1) DMCYVDT MT DME DMCYVDT MA Metabolism DMCYVDT RN Trimethadione metabolism by human liver cytochrome P450: evidence for the involvement of CYP2E1. Xenobiotica. 1998 Nov;28(11):1041-7. DMCYVDT RU https://www.ncbi.nlm.nih.gov/pubmed/?term=9879636 DMCYVDT DI DMCYVDT DMCYVDT DN Chlorzoxazone DMCYVDT MI DE4LYSA DMCYVDT MN Cytochrome P450 3A4 (CYP3A4) DMCYVDT MT DME DMCYVDT MA Metabolism DMCYVDT RN Summary of information on human CYP enzymes: human P450 metabolism data. Drug Metab Rev. 2002 Feb-May;34(1-2):83-448. DMCYVDT RU https://www.ncbi.nlm.nih.gov/pubmed/?term=11996015 DMGU74E DI DMGU74E DMGU74E DN Cholecalciferol DMGU74E MI TTK59TV DMGU74E MN Vitamin D3 receptor (VDR) DMGU74E MT DTT DMGU74E MA Binder DMGU74E RN [Vitamin D2 or vitamin D3]. Rev Med Interne. 2008 Oct;29(10):815-20. DMGU74E RU https://pubmed.ncbi.nlm.nih.gov/18406498 DM7OKQV DI DM7OKQV DM7OKQV DN Cholic acid DM7OKQV MI DT7JELC DM7OKQV MN Apical sodium-dependent bile acid transporter (SLC10A2) DM7OKQV MT DTP DM7OKQV MA Substrate DM7OKQV RN Expression and transport properties of the human ileal and renal sodium-dependent bile acid transporter. Am J Physiol. 1998 Jan;274(1):G157-69. DM7OKQV RU http://ajpgi.physiology.org/content/274/1/G157.long DM7OKQV DI DM7OKQV DM7OKQV DN Cholic acid DM7OKQV MI DTI7UX6 DM7OKQV MN Breast cancer resistance protein (ABCG2) DM7OKQV MT DTP DM7OKQV MA Substrate DM7OKQV RN Characterization of the role of ABCG2 as a bile acid transporter in liver and placenta. Mol Pharmacol. 2012 Feb;81(2):273-83. DM7OKQV RU https://doi.org/10.1124/mol.111.075143 DM7OKQV DI DM7OKQV DM7OKQV DN Cholic acid DM7OKQV MI TTQ6VF4 DM7OKQV MN Ferrochelatase (FECH) DM7OKQV MT DTT DM7OKQV MA Inhibitor DM7OKQV RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DM7OKQV RU https://pubmed.ncbi.nlm.nih.gov/17139284 DM7OKQV DI DM7OKQV DM7OKQV DN Cholic acid DM7OKQV MI TTMF541 DM7OKQV MN Liver carboxylesterase (CES1) DM7OKQV MT DTT DM7OKQV MA Inhibitor DM7OKQV RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DM7OKQV RU https://pubmed.ncbi.nlm.nih.gov/17139284 DM7OKQV DI DM7OKQV DM7OKQV DN Cholic acid DM7OKQV MI DTFI42L DM7OKQV MN Multidrug resistance-associated protein 2 (ABCC2) DM7OKQV MT DTP DM7OKQV MA Substrate DM7OKQV RN Multiple pathways for fluoroquinolone secretion by human intestinal epithelial (Caco-2) cells. Br J Pharmacol. 2002 Mar;135(5):1263-75. DM7OKQV RU https://doi.org/10.1038/sj.bjp.0704560 DM7OKQV DI DM7OKQV DM7OKQV DN Cholic acid DM7OKQV MI DTCSGPB DM7OKQV MN Multidrug resistance-associated protein 4 (ABCC4) DM7OKQV MT DTP DM7OKQV MA Substrate DM7OKQV RN Human intestinal transporter database: QSAR modeling and virtual profiling of drug uptake, efflux and interactions. Pharm Res. 2013 Apr;30(4):996-1007. DM7OKQV RU https://doi.org/10.1007/s11095-012-0935-x DM7OKQV DI DM7OKQV DM7OKQV DN Cholic acid DM7OKQV MI DTE2B1D DM7OKQV MN Organic anion transporting polypeptide 1A2 (SLCO1A2) DM7OKQV MT DTP DM7OKQV MA Substrate DM7OKQV RN Molecular and functional characterization of an organic anion transporting polypeptide cloned from human liver. Gastroenterology. 1995 Oct;109(4):1274-82. DM7OKQV RU http://www.ncbi.nlm.nih.gov/pubmed/7557095 DM7OKQV DI DM7OKQV DM7OKQV DN Cholic acid DM7OKQV MI DT3D8F0 DM7OKQV MN Organic anion transporting polypeptide 1B1 (SLCO1B1) DM7OKQV MT DTP DM7OKQV MA Substrate DM7OKQV RN Organic anion transporting polypeptide 1B1: a genetically polymorphic transporter of major importance for hepatic drug uptake. Pharmacol Rev. 2011 Mar;63(1):157-81. DM7OKQV RU http://www.ncbi.nlm.nih.gov/pubmed/21245207 DM7OKQV DI DM7OKQV DM7OKQV DN Cholic acid DM7OKQV MI TT9V5JH DM7OKQV MN Phospholipase A2 (PLA2G1B) DM7OKQV MT DTT DM7OKQV MA Inhibitor DM7OKQV RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DM7OKQV RU https://pubmed.ncbi.nlm.nih.gov/17139284 DM7OKQV DI DM7OKQV DM7OKQV DN Cholic acid DM7OKQV MI DEYWLRK DM7OKQV MN Sulfotransferase 1A1 (SULT1A1) DM7OKQV MT DME DM7OKQV MA Metabolism DM7OKQV RN Kinetic analysis of bile acid sulfation by stably expressed human sulfotransferase 2A1 (SULT2A1). Xenobiotica. 2010 Mar;40(3):184-94. DM7OKQV RU https://www.ncbi.nlm.nih.gov/pubmed/?term=20102295 DMOI1ZF DI DMOI1ZF DMOI1ZF DN Choline alfoscerate DMOI1ZF MI TTH18TF DMOI1ZF MN Muscarinic acetylcholine receptor M5 (CHRM5) DMOI1ZF MT DTT DMOI1ZF MA Modulator DMOI1ZF RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 467). DMOI1ZF RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=467 DM8P137 DI DM8P137 DM8P137 DN Choline salicylate DM8P137 MI DEAHED0 DM8P137 MN Choline dehydrogenase (CHDH) DM8P137 MT DME DM8P137 MA Metabolism DM8P137 RN Usual choline and betaine dietary intake and incident coronary heart disease: the atherosclerosis risk in communities (ARIC) study. BMC Cardiovasc Disord. 2007 Jul 13;7:20. DM8P137 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=17629908 DM8P137 DI DM8P137 DM8P137 DN Choline salicylate DM8P137 MI DE5NGOW DM8P137 MN Choline O-acetyltransferase (CHAT) DM8P137 MT DME DM8P137 MA Metabolism DM8P137 RN The effect of trichlorfon and methylazoxymethanol on the development of guinea pig cerebellum. Toxicol Appl Pharmacol. 2007 Mar;219(2-3):128-35. DM8P137 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=17150236 DM8P137 DI DM8P137 DM8P137 DN Choline salicylate DM8P137 MI DEL87ZT DM8P137 MN Choline/ethanolaminephosphotransferase 1 (CEPT1) DM8P137 MT DME DM8P137 MA Metabolism DM8P137 RN PC and PE synthesis: mixed micellar analysis of the cholinephosphotransferase and ethanolaminephosphotransferase activities of human choline/ethanolamine phosphotransferase 1 (CEPT1). Lipids. 2002 Jul;37(7):663-72. DM8P137 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=12216837 DMFMZ3G DI DMFMZ3G DMFMZ3G DN Choriogonadotropin alfa DMFMZ3G MI TT2O4W9 DMFMZ3G MN Luteinizing hormone receptor (LHCGR) DMFMZ3G MT DTT DMFMZ3G MA Modulator DMFMZ3G RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. DMFMZ3G RU https://www.fda.gov/ DMFT73E DI DMFT73E DMFT73E DN Chorionic Gonadotropin DMFT73E MI TT2O4W9 DMFT73E MN Luteinizing hormone receptor (LHCGR) DMFT73E MT DTT DMFT73E MA Modulator DMFT73E RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. DMFT73E RU https://www.fda.gov/ DM2NA4K DI DM2NA4K DM2NA4K DN Ciclesonide DM2NA4K MI TTJL8VG DM2NA4K MN Corticosteroid-binding globulin (SERPINA6) DM2NA4K MT DTT DM2NA4K MA Binder DM2NA4K RN Novel human corticosteroid-binding globulin variant with low cortisol-binding affinity. J Clin Endocrinol Metab. 2000 Jan;85(1):361-7. DM2NA4K RU https://pubmed.ncbi.nlm.nih.gov/10634411 DM2NA4K DI DM2NA4K DM2NA4K DN Ciclesonide DM2NA4K MI DECB0K3 DM2NA4K MN Cytochrome P450 2D6 (CYP2D6) DM2NA4K MT DME DM2NA4K MA Metabolism DM2NA4K RN Identification of enzymes involved in phase I metabolism of ciclesonide by human liver microsomes. Eur J Drug Metab Pharmacokinet. 2005 Oct-Dec;30(4):275-86. DM2NA4K RU https://www.ncbi.nlm.nih.gov/pubmed/?term=16435573 DM2NA4K DI DM2NA4K DM2NA4K DN Ciclesonide DM2NA4K MI DE4LYSA DM2NA4K MN Cytochrome P450 3A4 (CYP3A4) DM2NA4K MT DME DM2NA4K MA Metabolism DM2NA4K RN Identification of enzymes involved in phase I metabolism of ciclesonide by human liver microsomes. Eur J Drug Metab Pharmacokinet. 2005 Oct-Dec;30(4):275-86. DM2NA4K RU https://www.ncbi.nlm.nih.gov/pubmed/?term=16435573 DM2NA4K DI DM2NA4K DM2NA4K DN Ciclesonide DM2NA4K MI DTUGYRD DM2NA4K MN P-glycoprotein 1 (ABCB1) DM2NA4K MT DTP DM2NA4K MA Substrate DM2NA4K RN Oral and inhaled corticosteroids: differences in P-glycoprotein (ABCB1) mediated efflux. Toxicol Appl Pharmacol. 2012 May 1;260(3):294-302. DM2NA4K RU https://doi.org/10.1016/j.taap.2012.03.008 DMN5T2A DI DMN5T2A DMN5T2A DN Ciclopirox DMN5T2A MI TTJQFBG DMN5T2A MN HIF-prolyl hydroxylase (HPH) DMN5T2A MT DTT DMN5T2A MA Modulator DMN5T2A RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. DMN5T2A RU https://www.fda.gov/ DMT2KRV DI DMT2KRV DMT2KRV DN Ciclosporin DMT2KRV MI DTI7UX6 DMT2KRV MN Breast cancer resistance protein (ABCG2) DMT2KRV MT DTP DMT2KRV MA Substrate DMT2KRV RN Mammalian drug efflux transporters of the ATP binding cassette (ABC) family in multidrug resistance: A review of the past decade. Cancer Lett. 2016 Jan 1;370(1):153-64. DMT2KRV RU http://www.ncbi.nlm.nih.gov/pubmed/26499806 DMT2KRV DI DMT2KRV DMT2KRV DN Ciclosporin DMT2KRV MI TTA4LDE DMT2KRV MN Calcineurin (PPP3CA) DMT2KRV MT DTT DMT2KRV MA Inhibitor DMT2KRV RN Cyclosporine and tacrolimus for the treatment of rheumatoid arthritis. Curr Opin Rheumatol. 2007 May;19(3):238-45. DMT2KRV RU https://pubmed.ncbi.nlm.nih.gov/17414949 DMAZJFX DI DMAZJFX DMAZJFX DN Ciclosporin DMAZJFX MI DE4LYSA DMAZJFX MN Cytochrome P450 3A4 (CYP3A4) DMAZJFX MT DME DMAZJFX MA Metabolism DMAZJFX RN Dasatinib significantly reduced in vivo exposure to cyclosporine in a rat model: The possible involvement of CYP3A induction. Pharmacol Rep. 2019 Apr;71(2):201-205. DMAZJFX RU https://www.ncbi.nlm.nih.gov/pubmed/?term=30785057 DMAZJFX DI DMAZJFX DMAZJFX DN Ciclosporin DMAZJFX MI DEIBDNY DMAZJFX MN Cytochrome P450 3A5 (CYP3A5) DMAZJFX MT DME DMAZJFX MA Metabolism DMAZJFX RN CYP3A4*18B and CYP3A5*3 polymorphisms contribute to pharmacokinetic variability of cyclosporine among healthy Chinese subjects. Eur J Pharm Sci. 2015 Aug 30;76:238-44. DMAZJFX RU https://www.ncbi.nlm.nih.gov/pubmed/?term=25976223 DMAZJFX DI DMAZJFX DMAZJFX DN Ciclosporin DMAZJFX MI DERD86B DMAZJFX MN Cytochrome P450 3A7 (CYP3A7) DMAZJFX MT DME DMAZJFX MA Metabolism DMAZJFX RN CYP3A7, CYP3A5, CYP3A4, and ABCB1 genetic polymorphisms, cyclosporine concentration, and dose requirement in transplant recipients. Ther Drug Monit. 2008 Dec;30(6):689-99. DMAZJFX RU https://www.ncbi.nlm.nih.gov/pubmed/?term=18978522 DMT2KRV DI DMT2KRV DMT2KRV DN Ciclosporin DMT2KRV MI DTFI42L DMT2KRV MN Multidrug resistance-associated protein 2 (ABCC2) DMT2KRV MT DTP DMT2KRV MA Substrate DMT2KRV RN Is cyclosporine A transport inhibited by pravastatin via multidrug resistant protein 2? Eur J Clin Pharmacol. 2010 Feb;66(2):153-8. DMT2KRV RU https://doi.org/10.1007/s00228-009-0740-6 DMT2KRV DI DMT2KRV DMT2KRV DN Ciclosporin DMT2KRV MI DTUGYRD DMT2KRV MN P-glycoprotein 1 (ABCB1) DMT2KRV MT DTP DMT2KRV MA Substrate DMT2KRV RN Contribution of down-regulation of intestinal and hepatic cytochrome P450 3A to increased absorption of cyclosporine A in a rat nephrosis model. J Pharmacol Exp Ther. 2008 Nov;327(2):592-9. DMT2KRV RU http://www.ncbi.nlm.nih.gov/pubmed/18725544 DMA13GD DI DMA13GD DMA13GD DN Cidofovir DMA13GD MI TTIU7X1 DMA13GD MN Herpes simplex virus DNA polymerase UL30 (HSV UL30) DMA13GD MT DTT DMA13GD MA Modulator DMA13GD RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. DMA13GD RU https://www.fda.gov/ DMA13GD DI DMA13GD DMA13GD DN Cidofovir DMA13GD MI DTFI42L DMA13GD MN Multidrug resistance-associated protein 2 (ABCC2) DMA13GD MT DTP DMA13GD MA Substrate DMA13GD RN Mammalian drug efflux transporters of the ATP binding cassette (ABC) family in multidrug resistance: A review of the past decade. Cancer Lett. 2016 Jan 1;370(1):153-64. DMA13GD RU http://www.ncbi.nlm.nih.gov/pubmed/26499806 DMA13GD DI DMA13GD DMA13GD DN Cidofovir DMA13GD MI DTQ23VB DMA13GD MN Organic anion transporter 1 (SLC22A6) DMA13GD MT DTP DMA13GD MA Substrate DMA13GD RN Renal transport of adefovir, cidofovir, and tenofovir by SLC22A family members (hOAT1, hOAT3, and hOCT2). Pharm Res. 2007 Apr;24(4):811-5. DMA13GD RU http://www.ncbi.nlm.nih.gov/pubmed/17372702 DMA13GD DI DMA13GD DMA13GD DN Cidofovir DMA13GD MI DTVP67E DMA13GD MN Organic anion transporter 3 (SLC22A8) DMA13GD MT DTP DMA13GD MA Substrate DMA13GD RN Renal transport of adefovir, cidofovir, and tenofovir by SLC22A family members (hOAT1, hOAT3, and hOCT2). Pharm Res. 2007 Apr;24(4):811-5. DMA13GD RU http://www.ncbi.nlm.nih.gov/pubmed/17372702 DME2H5T DI DME2H5T DME2H5T DN Cilastatin DME2H5T MI TTYUENF DME2H5T MN Dehydropeptidase I (DPEP1) DME2H5T MT DTT DME2H5T MA Inhibitor DME2H5T RN Pharmacokinetic study of pleural fluid penetration of carbapenem antibiotic agents in chemical pleurisy. Respir Med. 2006 Feb;100(2):324-31. DME2H5T RU https://pubmed.ncbi.nlm.nih.gov/16493791 DM4V6JA DI DM4V6JA DM4V6JA DN Cilazapril DM4V6JA MI TTL69WB DM4V6JA MN Angiotensin-converting enzyme (ACE) DM4V6JA MT DTT DM4V6JA MA Inhibitor DM4V6JA RN Triple pharmacological blockade of the renin-angiotensin-aldosterone system in nondiabetic CKD: an open-label crossover randomized controlled trial. Am J Kidney Dis. 2008 Sep;52(3):486-93. DM4V6JA RU https://pubmed.ncbi.nlm.nih.gov/18423812 DMZMSCT DI DMZMSCT DMZMSCT DN Cilostazol DMZMSCT MI DEJGDUW DMZMSCT MN Cytochrome P450 1A2 (CYP1A2) DMZMSCT MT DME DMZMSCT MA Metabolism DMZMSCT RN Effects of CYP3A inhibition on the metabolism of cilostazol. Clin Pharmacokinet. 1999;37 Suppl 2:61-8. DMZMSCT RU https://www.ncbi.nlm.nih.gov/pubmed/?term=10702888 DMZMSCT DI DMZMSCT DMZMSCT DN Cilostazol DMZMSCT MI DECB0K3 DMZMSCT MN Cytochrome P450 2D6 (CYP2D6) DMZMSCT MT DME DMZMSCT MA Metabolism DMZMSCT RN Effects of CYP3A inhibition on the metabolism of cilostazol. Clin Pharmacokinet. 1999;37 Suppl 2:61-8. DMZMSCT RU https://www.ncbi.nlm.nih.gov/pubmed/?term=10702888 DMZMSCT DI DMZMSCT DMZMSCT DN Cilostazol DMZMSCT MI DE4LYSA DMZMSCT MN Cytochrome P450 3A4 (CYP3A4) DMZMSCT MT DME DMZMSCT MA Metabolism DMZMSCT RN Effects of CYP3A inhibition on the metabolism of cilostazol. Clin Pharmacokinet. 1999;37 Suppl 2:61-8. DMZMSCT RU https://www.ncbi.nlm.nih.gov/pubmed/?term=10702888 DMZMSCT DI DMZMSCT DMZMSCT DN Cilostazol DMZMSCT MI DEIBDNY DMZMSCT MN Cytochrome P450 3A5 (CYP3A5) DMZMSCT MT DME DMZMSCT MA Metabolism DMZMSCT RN Effects of CYP3A inhibition on the metabolism of cilostazol. Clin Pharmacokinet. 1999;37 Suppl 2:61-8. DMZMSCT RU https://www.ncbi.nlm.nih.gov/pubmed/?term=10702888 DMZMSCT DI DMZMSCT DMZMSCT DN Cilostazol DMZMSCT MI DERD86B DMZMSCT MN Cytochrome P450 3A7 (CYP3A7) DMZMSCT MT DME DMZMSCT MA Metabolism DMZMSCT RN Effects of CYP3A inhibition on the metabolism of cilostazol. Clin Pharmacokinet. 1999;37 Suppl 2:61-8. DMZMSCT RU https://www.ncbi.nlm.nih.gov/pubmed/?term=10702888 DMZMSCT DI DMZMSCT DMZMSCT DN Cilostazol DMZMSCT MI DEGTFWK DMZMSCT MN Mephenytoin 4-hydroxylase (CYP2C19) DMZMSCT MT DME DMZMSCT MA Metabolism DMZMSCT RN Effects of CYP3A inhibition on the metabolism of cilostazol. Clin Pharmacokinet. 1999;37 Suppl 2:61-8. DMZMSCT RU https://www.ncbi.nlm.nih.gov/pubmed/?term=10702888 DMZMSCT DI DMZMSCT DMZMSCT DN Cilostazol DMZMSCT MI DTVP67E DMZMSCT MN Organic anion transporter 3 (SLC22A8) DMZMSCT MT DTP DMZMSCT MA Substrate DMZMSCT RN Aspirin and probenecid inhibit organic anion transporter 3-mediated renal uptake of cilostazol and probenecid induces metabolism of cilostazol in the rat. Drug Metab Dispos. 2014 Jun;42(6):996-1007. DMZMSCT RU http://www.ncbi.nlm.nih.gov/pubmed/24692216 DMZMSCT DI DMZMSCT DMZMSCT DN Cilostazol DMZMSCT MI DT3D8F0 DMZMSCT MN Organic anion transporting polypeptide 1B1 (SLCO1B1) DMZMSCT MT DTP DMZMSCT MA Substrate DMZMSCT RN Organic Anion-Transporting Polypeptide and Efflux Transporter-Mediated Hepatic Uptake and Biliary Excretion of Cilostazol and Its Metabolites in Rats and Humans. J Pharm Sci. 2017 Sep;106(9):2515-2523. DMZMSCT RU http://www.ncbi.nlm.nih.gov/pubmed/28535976 DMZMSCT DI DMZMSCT DMZMSCT DN Cilostazol DMZMSCT MI DT9C1TS DMZMSCT MN Organic anion transporting polypeptide 1B3 (SLCO1B3) DMZMSCT MT DTP DMZMSCT MA Substrate DMZMSCT RN Organic Anion-Transporting Polypeptide and Efflux Transporter-Mediated Hepatic Uptake and Biliary Excretion of Cilostazol and Its Metabolites in Rats and Humans. J Pharm Sci. 2017 Sep;106(9):2515-2523. DMZMSCT RU http://www.ncbi.nlm.nih.gov/pubmed/28535976 DMZMSCT DI DMZMSCT DMZMSCT DN Cilostazol DMZMSCT MI TTZCG4L DMZMSCT MN Phosphodiesterase 3 (PDE3) DMZMSCT MT DTT DMZMSCT MA Modulator DMZMSCT RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. DMZMSCT RU https://www.fda.gov/ DMZMSCT DI DMZMSCT DMZMSCT DN Cilostazol DMZMSCT MI TT06AWU DMZMSCT MN Phosphodiesterase 3A (PDE3A) DMZMSCT MT DTT DMZMSCT MA Inhibitor DMZMSCT RN A new generation of phosphodiesterase inhibitors: multiple molecular forms of phosphodiesterase and the potential for drug selectivity. J Med Chem. 1985 May;28(5):537-45. DMZMSCT RU https://pubmed.ncbi.nlm.nih.gov/2985781 DMH61ZB DI DMH61ZB DMH61ZB DN Cimetidine DMH61ZB MI DTI7UX6 DMH61ZB MN Breast cancer resistance protein (ABCG2) DMH61ZB MT DTP DMH61ZB MA Substrate DMH61ZB RN Progesterone acts via progesterone receptors A and B to regulate breast cancer resistance protein expression. Mol Pharmacol. 2008 Mar;73(3):613-5. DMH61ZB RU http://www.ncbi.nlm.nih.gov/pubmed/18086804 DMH61ZB DI DMH61ZB DMH61ZB DN Cimetidine DMH61ZB MI TTQHJ1K DMH61ZB MN Histamine H2 receptor (H2R) DMH61ZB MT DTT DMH61ZB MA Antagonist DMH61ZB RN Histamine H1 and H2 receptor antagonists accelerate skin barrier repair and prevent epidermal hyperplasia induced by barrier disruption in a dry environment. J Invest Dermatol. 2001 Feb;116(2):261-5. DMH61ZB RU https://pubmed.ncbi.nlm.nih.gov/11180002 DMH61ZB DI DMH61ZB DMH61ZB DN Cimetidine DMH61ZB MI DTZGT0P DMH61ZB MN Multidrug and toxin extrusion protein 1 (SLC47A1) DMH61ZB MT DTP DMH61ZB MA Substrate DMH61ZB RN Substrate specificity of MATE1 and MATE2-K, human multidrug and toxin extrusions/H(+)-organic cation antiporters. Biochem Pharmacol. 2007 Jul 15;74(2):359-71. DMH61ZB RU http://www.ncbi.nlm.nih.gov/pubmed/17509534 DMH61ZB DI DMH61ZB DMH61ZB DN Cimetidine DMH61ZB MI DT3TX4H DMH61ZB MN Multidrug and toxin extrusion protein 2 (SLC47A2) DMH61ZB MT DTP DMH61ZB MA Substrate DMH61ZB RN Substrate specificity of MATE1 and MATE2-K, human multidrug and toxin extrusions/H(+)-organic cation antiporters. Biochem Pharmacol. 2007 Jul 15;74(2):359-71. DMH61ZB RU http://www.ncbi.nlm.nih.gov/pubmed/17509534 DMH61ZB DI DMH61ZB DMH61ZB DN Cimetidine DMH61ZB MI DTVP67E DMH61ZB MN Organic anion transporter 3 (SLC22A8) DMH61ZB MT DTP DMH61ZB MA Substrate DMH61ZB RN Transport of the dipeptidyl peptidase-4 inhibitor sitagliptin by human organic anion transporter 3, organic anion transporting polypeptide 4C1, and multidrug resistance P-glycoprotein. J Pharmacol Exp Ther. 2007 May;321(2):673-83. DMH61ZB RU http://www.ncbi.nlm.nih.gov/pubmed/17314201 DMH61ZB DI DMH61ZB DMH61ZB DN Cimetidine DMH61ZB MI DTT79CX DMH61ZB MN Organic cation transporter 1 (SLC22A1) DMH61ZB MT DTP DMH61ZB MA Substrate DMH61ZB RN Identification of novel substrates and structure-activity relationship of cellular uptake mediated by human organic cation transporters 1 and 2. J Med Chem. 2013 Sep 26;56(18):7232-42. DMH61ZB RU http://www.ncbi.nlm.nih.gov/pubmed/23984907 DMH61ZB DI DMH61ZB DMH61ZB DN Cimetidine DMH61ZB MI DT9IDPW DMH61ZB MN Organic cation transporter 2 (SLC22A2) DMH61ZB MT DTP DMH61ZB MA Substrate DMH61ZB RN Elevated systemic elimination of cimetidine in rats with acute biliary obstruction: the role of renal organic cation transporter OCT2. Drug Metab Pharmacokinet. 2010;25(4):328-34. DMH61ZB RU http://www.ncbi.nlm.nih.gov/pubmed/20814153 DMH61ZB DI DMH61ZB DMH61ZB DN Cimetidine DMH61ZB MI DTUGYRD DMH61ZB MN P-glycoprotein 1 (ABCB1) DMH61ZB MT DTP DMH61ZB MA Substrate DMH61ZB RN Mammalian drug efflux transporters of the ATP binding cassette (ABC) family in multidrug resistance: A review of the past decade. Cancer Lett. 2016 Jan 1;370(1):153-64. DMH61ZB RU http://www.ncbi.nlm.nih.gov/pubmed/26499806 DMZHPNE DI DMZHPNE DMZHPNE DN Cimetropium bromide DMZHPNE MI TTH18TF DMZHPNE MN Muscarinic acetylcholine receptor M5 (CHRM5) DMZHPNE MT DTT DMZHPNE MA Modulator DMZHPNE RN Natural products as sources of new drugs over the last 25 years. J Nat Prod. 2007 Mar;70(3):461-77. DMZHPNE RU https://pubmed.ncbi.nlm.nih.gov/17309302 DMCX0K3 DI DMCX0K3 DMCX0K3 DN Cinacalcet DMCX0K3 MI DEJGDUW DMCX0K3 MN Cytochrome P450 1A2 (CYP1A2) DMCX0K3 MT DME DMCX0K3 MA Metabolism DMCX0K3 RN Effects of CYP3A inhibition on the metabolism of cilostazol. Clin Pharmacokinet. 1999;37 Suppl 2:61-8. DMCX0K3 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=10702888 DMCX0K3 DI DMCX0K3 DMCX0K3 DN Cinacalcet DMCX0K3 MI DECB0K3 DMCX0K3 MN Cytochrome P450 2D6 (CYP2D6) DMCX0K3 MT DME DMCX0K3 MA Metabolism DMCX0K3 RN Clinical pharmacokinetic and pharmacodynamic profile of cinacalcet hydrochloride. Clin Pharmacokinet. 2009;48(5):303-11. DMCX0K3 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=19566113 DMCX0K3 DI DMCX0K3 DMCX0K3 DN Cinacalcet DMCX0K3 MI DE4LYSA DMCX0K3 MN Cytochrome P450 3A4 (CYP3A4) DMCX0K3 MT DME DMCX0K3 MA Metabolism DMCX0K3 RN Clinical pharmacokinetic and pharmacodynamic profile of cinacalcet hydrochloride. Clin Pharmacokinet. 2009;48(5):303-11. DMCX0K3 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=19566113 DMCX0K3 DI DMCX0K3 DMCX0K3 DN Cinacalcet DMCX0K3 MI TTBUYHA DMCX0K3 MN Extracellular calcium-sensing receptor (CASR) DMCX0K3 MT DTT DMCX0K3 MA Agonist DMCX0K3 RN Clinical pipeline report, company report or official report of Amgen (2009). DMCX0K3 RU http://www.amgen.com/science/pipe.jsp DMFIC0M DI DMFIC0M DMFIC0M DN Cinalukast DMFIC0M MI TTGKOY9 DMFIC0M MN Leukotriene CysLT1 receptor (CYSLTR1) DMFIC0M MT DTT DMFIC0M MA Antagonist DMFIC0M RN Prolonged protection against exercise-induced bronchoconstriction by the leukotriene D4-receptor antagonist cinalukast. J Allergy Clin Immunol. 1997 Feb;99(2):210-5. DMFIC0M RU https://pubmed.ncbi.nlm.nih.gov/9042047 DM7U5QJ DI DM7U5QJ DM7U5QJ DN Cinnarizine DM7U5QJ MI DEJGDUW DM7U5QJ MN Cytochrome P450 1A2 (CYP1A2) DM7U5QJ MT DME DM7U5QJ MA Metabolism DM7U5QJ RN Insights into the substrate specificity, inhibitors, regulation, and polymorphisms and the clinical impact of human cytochrome P450 1A2. AAPS J. 2009 Sep;11(3):481-94. 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DM2NLS9 RU http://www.ncbi.nlm.nih.gov/pubmed/19307362 DM2NLS9 DI DM2NLS9 DM2NLS9 DN Ciprofloxacin XR DM2NLS9 MI DTVP67E DM2NLS9 MN Organic anion transporter 3 (SLC22A8) DM2NLS9 MT DTP DM2NLS9 MA Substrate DM2NLS9 RN Organic anion transporter 3 (oat3/slc22a8) interacts with carboxyfluoroquinolones, and deletion increases systemic exposure to ciprofloxacin. Mol Pharmacol. 2008 Jul;74(1):122-31. DM2NLS9 RU http://www.ncbi.nlm.nih.gov/pubmed/18381565 DM2NLS9 DI DM2NLS9 DM2NLS9 DN Ciprofloxacin XR DM2NLS9 MI DTE2B1D DM2NLS9 MN Organic anion transporting polypeptide 1A2 (SLCO1A2) DM2NLS9 MT DTP DM2NLS9 MA Substrate DM2NLS9 RN Fruit juice inhibition of uptake transport: a new type of food-drug interaction. Br J Clin Pharmacol. 2010 Nov;70(5):645-55. DM2NLS9 RU http://www.ncbi.nlm.nih.gov/pubmed/21039758 DM2NLS9 DI DM2NLS9 DM2NLS9 DN Ciprofloxacin XR DM2NLS9 MI TTIXTO3 DM2NLS9 MN Staphylococcus Topoisomerase IV (Stap-coc parC) DM2NLS9 MT DTT DM2NLS9 MA Modulator DM2NLS9 RN Drugs@FDA. 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DMRHGI9 RU https://doi.org/10.1016/j.bcp.2008.11.007 DMRHGI9 DI DMRHGI9 DMRHGI9 DN Cisplatin DMRHGI9 MI DT206GF DMRHGI9 MN Copper-transporting ATPase 2 (ATP7B) DMRHGI9 MT DTP DMRHGI9 MA Substrate DMRHGI9 RN Effect of cisplatin on the transport activity of PII-type ATPases. Metallomics. 2017 Jul 19;9(7):960-968. DMRHGI9 RU http://www.ncbi.nlm.nih.gov/pubmed/28636017 DMRHGI9 DI DMRHGI9 DMRHGI9 DN Cisplatin DMRHGI9 MI DEVDYN7 DMRHGI9 MN Cytochrome P450 2E1 (CYP2E1) DMRHGI9 MT DME DMRHGI9 MA Metabolism DMRHGI9 RN Cytochrome P450 2E1 null mice provide novel protection against cisplatin-induced nephrotoxicity and apoptosis. Kidney Int. 2003 May;63(5):1687-96. DMRHGI9 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=12675844 DMRHGI9 DI DMRHGI9 DMRHGI9 DN Cisplatin DMRHGI9 MI DE4ZHS1 DMRHGI9 MN Glutathione S-transferase alpha-1 (GSTA1) DMRHGI9 MT DME DMRHGI9 MA Metabolism DMRHGI9 RN Role of glutathione S-transferase P1-1 in the cellular detoxification of cisplatin. Mol Cancer Ther. 2008 Oct;7(10):3247-55. DMRHGI9 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=18852128 DMRHGI9 DI DMRHGI9 DMRHGI9 DN Cisplatin DMRHGI9 MI DEH7XYP DMRHGI9 MN Glutathione S-transferase alpha-4 (GSTA4) DMRHGI9 MT DME DMRHGI9 MA Metabolism DMRHGI9 RN GSTA4 mediates reduction of cisplatin ototoxicity in female mice. Nat Commun. 2019 Sep 12;10(1):4150. DMRHGI9 RU https://pubmed.ncbi.nlm.nih.gov/31515474 DMRHGI9 DI DMRHGI9 DMRHGI9 DN Cisplatin DMRHGI9 MI DEYZEJA DMRHGI9 MN Glutathione S-transferase mu-1 (GSTM1) DMRHGI9 MT DME DMRHGI9 MA Metabolism DMRHGI9 RN Glutathione S-transferase genetic polymorphisms and individual sensitivity to the ototoxic effect of cisplatin. Anticancer Drugs. 2000 Sep;11(8):639-43. DMRHGI9 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=11081456 DMRHGI9 DI DMRHGI9 DMRHGI9 DN Cisplatin DMRHGI9 MI DEK6079 DMRHGI9 MN Glutathione S-transferase pi (GSTP1) DMRHGI9 MT DME DMRHGI9 MA Metabolism DMRHGI9 RN Glutathione S-transferase genetic polymorphisms and individual sensitivity to the ototoxic effect of cisplatin. Anticancer Drugs. 2000 Sep;11(8):639-43. DMRHGI9 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=11081456 DMRHGI9 DI DMRHGI9 DMRHGI9 DN Cisplatin DMRHGI9 MI DE3PKUG DMRHGI9 MN Glutathione S-transferase theta-1 (GSTT1) DMRHGI9 MT DME DMRHGI9 MA Metabolism DMRHGI9 RN Glutathione S-transferase genetic polymorphisms and individual sensitivity to the ototoxic effect of cisplatin. Anticancer Drugs. 2000 Sep;11(8):639-43. 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DMRHGI9 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=10709094 DMRHGI9 DI DMRHGI9 DMRHGI9 DN Cisplatin DMRHGI9 MI DEFKGT7 DMRHGI9 MN Metallothionein-2A (MT2A) DMRHGI9 MT DME DMRHGI9 MA Metabolism DMRHGI9 RN Role of metallothionein in cisplatin sensitivity of germ-cell tumours. Int J Cancer. 2000 Mar 15;85(6):777-81. DMRHGI9 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=10709094 DMRHGI9 DI DMRHGI9 DMRHGI9 DN Cisplatin DMRHGI9 MI DTSYQGK DMRHGI9 MN Multidrug resistance-associated protein 1 (ABCC1) DMRHGI9 MT DTP DMRHGI9 MA Substrate DMRHGI9 RN Hammerhead ribozyme against gamma-glutamylcysteine synthetase sensitizes human colonic cancer cells to cisplatin by down-regulating both the glutathione synthesis and the expression of multidrug resistance proteins. Cancer Gene Ther. 2001 Oct;8(10):803-14. DMRHGI9 RU http://www.ncbi.nlm.nih.gov/pubmed/11687904 DMRHGI9 DI DMRHGI9 DMRHGI9 DN Cisplatin DMRHGI9 MI DTFI42L DMRHGI9 MN Multidrug resistance-associated protein 2 (ABCC2) DMRHGI9 MT DTP DMRHGI9 MA Substrate DMRHGI9 RN Lentivirus-mediated RNAi silencing targeting ABCC2 increasing the sensitivity of a human nasopharyngeal carcinoma cell line against cisplatin. J Transl Med. 2008 Oct 4;6:55. DMRHGI9 RU http://www.ncbi.nlm.nih.gov/pubmed/18834541 DMRHGI9 DI DMRHGI9 DMRHGI9 DN Cisplatin DMRHGI9 MI DT582KR DMRHGI9 MN Multidrug resistance-associated protein 6 (ABCC6) DMRHGI9 MT DTP DMRHGI9 MA Substrate DMRHGI9 RN Characterization of the drug resistance and transport properties of multidrug resistance protein 6 (MRP6, ABCC6). Cancer Res. 2002 Nov 1;62(21):6172-7. DMRHGI9 RU http://www.ncbi.nlm.nih.gov/pubmed/12414644 DMRHGI9 DI DMRHGI9 DMRHGI9 DN Cisplatin DMRHGI9 MI DEA3U9Y DMRHGI9 MN Myeloperoxidase (MPO) DMRHGI9 MT DME DMRHGI9 MA Metabolism DMRHGI9 RN Cisplatin reduces Brucella melitensis-infected cell number by inducing apoptosis, oxidant and pro-inflammatory cytokine production. Res Vet Sci. 2010 Apr;88(2):218-26. DMRHGI9 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=19818462 DMRHGI9 DI DMRHGI9 DMRHGI9 DN Cisplatin DMRHGI9 MI DTT79CX DMRHGI9 MN Organic cation transporter 1 (SLC22A1) DMRHGI9 MT DTP DMRHGI9 MA Substrate DMRHGI9 RN Cisplatin and oxaliplatin, but not carboplatin and nedaplatin, are substrates for human organic cation transporters (SLC22A1-3 and multidrug and toxin extrusion family). J Pharmacol Exp Ther. 2006 Nov;319(2):879-86. DMRHGI9 RU http://www.ncbi.nlm.nih.gov/pubmed/16914559 DMRHGI9 DI DMRHGI9 DMRHGI9 DN Cisplatin DMRHGI9 MI DT9IDPW DMRHGI9 MN Organic cation transporter 2 (SLC22A2) DMRHGI9 MT DTP DMRHGI9 MA Substrate DMRHGI9 RN Cisplatin nephrotoxicity is critically mediated via the human organic cation transporter 2. Am J Pathol. 2005 Dec;167(6):1477-84. DMRHGI9 RU http://www.ncbi.nlm.nih.gov/pubmed/16314463 DMRHGI9 DI DMRHGI9 DMRHGI9 DN Cisplatin DMRHGI9 MI DTUGYRD DMRHGI9 MN P-glycoprotein 1 (ABCB1) DMRHGI9 MT DTP DMRHGI9 MA Substrate DMRHGI9 RN Mammalian drug efflux transporters of the ATP binding cassette (ABC) family in multidrug resistance: A review of the past decade. Cancer Lett. 2016 Jan 1;370(1):153-64. DMRHGI9 RU http://www.ncbi.nlm.nih.gov/pubmed/26499806 DMRHGI9 DI DMRHGI9 DMRHGI9 DN Cisplatin DMRHGI9 MI DT8Q56F DMRHGI9 MN Probable low affinity copper uptake protein 2 (SLC31A2) DMRHGI9 MT DTP DMRHGI9 MA Substrate DMRHGI9 RN Copper transporter 2 regulates endocytosis and controls tumor growth and sensitivity to cisplatin in vivo. Mol Pharmacol. 2011 Jan;79(1):157-66. DMRHGI9 RU http://www.ncbi.nlm.nih.gov/pubmed/20930109 DMRHGI9 DI DMRHGI9 DMRHGI9 DN Cisplatin DMRHGI9 MI DENP5RY DMRHGI9 MN Quinone reductase 1 (NQO1) DMRHGI9 MT DME DMRHGI9 MA Metabolism DMRHGI9 RN PharmGKB: A worldwide resource for pharmacogenomic information. Wiley Interdiscip Rev Syst Biol Med. 2018 Jul;10(4):e1417. (ID: PA150642262) DMRHGI9 RU https://www.pharmgkb.org/pathway/PA150642262 DMRHGI9 DI DMRHGI9 DMRHGI9 DN Cisplatin DMRHGI9 MI DEUTDON DMRHGI9 MN Superoxide dismutase 1 (SOD1) DMRHGI9 MT DME DMRHGI9 MA Metabolism DMRHGI9 RN PharmGKB: A worldwide resource for pharmacogenomic information. Wiley Interdiscip Rev Syst Biol Med. 2018 Jul;10(4):e1417. (ID: PA150642262) DMRHGI9 RU https://www.pharmgkb.org/pathway/PA150642262 DM2G9AE DI DM2G9AE DM2G9AE DN Citalopram DM2G9AE MI DECB0K3 DM2G9AE MN Cytochrome P450 2D6 (CYP2D6) DM2G9AE MT DME DM2G9AE MA Metabolism DM2G9AE RN Pharmacokinetic-pharmacodynamic relationship of the selective serotonin reuptake inhibitors. Clin Pharmacokinet. 1996 Dec;31(6):444-69. DM2G9AE RU https://www.ncbi.nlm.nih.gov/pubmed/?term=8968657 DM2G9AE DI DM2G9AE DM2G9AE DN Citalopram DM2G9AE MI DEVDYN7 DM2G9AE MN Cytochrome P450 2E1 (CYP2E1) DM2G9AE MT DME DM2G9AE MA Metabolism DM2G9AE RN Antidepressant drugs in the elderly--role of the cytochrome P450 2D6. World J Biol Psychiatry. 2003 Apr;4(2):74-80. DM2G9AE RU https://www.ncbi.nlm.nih.gov/pubmed/?term=12692778 DM2G9AE DI DM2G9AE DM2G9AE DN Citalopram DM2G9AE MI DE4LYSA DM2G9AE MN Cytochrome P450 3A4 (CYP3A4) DM2G9AE MT DME DM2G9AE MA Metabolism DM2G9AE RN PharmGKB summary: citalopram pharmacokinetics pathway. Pharmacogenet Genomics. 2011 Nov;21(11):769-72. DM2G9AE RU https://www.ncbi.nlm.nih.gov/pubmed/?term=21546862 DM2G9AE DI DM2G9AE DM2G9AE DN Citalopram DM2G9AE MI DEGTFWK DM2G9AE MN Mephenytoin 4-hydroxylase (CYP2C19) DM2G9AE MT DME DM2G9AE MA Metabolism DM2G9AE RN Citalopram and desmethylcitalopram in vitro: human cytochromes mediating transformation, and cytochrome inhibitory effects. Biol Psychiatry. 1999 Sep 15;46(6):839-49. DM2G9AE RU https://www.ncbi.nlm.nih.gov/pubmed/?term=10494454 DM2G9AE DI DM2G9AE DM2G9AE DN Citalopram DM2G9AE MI DTSYQGK DM2G9AE MN Multidrug resistance-associated protein 1 (ABCC1) DM2G9AE MT DTP DM2G9AE MA Substrate DM2G9AE RN MRP1 polymorphisms associated with citalopram response in patients with major depression. J Clin Psychopharmacol. 2010 Apr;30(2):116-25. DM2G9AE RU http://www.ncbi.nlm.nih.gov/pubmed/20520284 DM2G9AE DI DM2G9AE DM2G9AE DN Citalopram DM2G9AE MI DTT79CX DM2G9AE MN Organic cation transporter 1 (SLC22A1) DM2G9AE MT DTP DM2G9AE MA Substrate DM2G9AE RN Organic cation transporters and their pharmacokinetic and pharmacodynamic consequences. Drug Metab Pharmacokinet. 2008;23(4):243-53. DM2G9AE RU https://doi.org/10.2133/dmpk.23.243 DM2G9AE DI DM2G9AE DM2G9AE DN Citalopram DM2G9AE MI DTUGYRD DM2G9AE MN P-glycoprotein 1 (ABCB1) DM2G9AE MT DTP DM2G9AE MA Substrate DM2G9AE RN ABCB1 gene polymorphisms are associated with fatal intoxications involving venlafaxine but not citalopram. Int J Legal Med. 2013 May;127(3):579-86. DM2G9AE RU http://www.ncbi.nlm.nih.gov/pubmed/23515680 DM2G9AE DI DM2G9AE DM2G9AE DN Citalopram DM2G9AE MI TT3ROYC DM2G9AE MN Serotonin transporter (SERT) DM2G9AE MT DTT DM2G9AE MA Modulator DM2G9AE RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. DM2G9AE RU https://www.fda.gov/ DMI4XBM DI DMI4XBM DMI4XBM DN Citicoline DMI4XBM MI DEQJ8N3 DMI4XBM MN ASM-like phosphodiesterase 3a (SMPDL3A) DMI4XBM MT DME DMI4XBM MA Metabolism DMI4XBM RN The structure and catalytic mechanism of human sphingomyelin phosphodiesterase like 3a--an acid sphingomyelinase homologue with a novel nucleotide hydrolase activity. FEBS J. 2016 Mar;283(6):1107-23. DMI4XBM RU https://www.ncbi.nlm.nih.gov/pubmed/?term=26783088 DMI4XBM DI DMI4XBM DMI4XBM DN Citicoline DMI4XBM MI DEH6S1Q DMI4XBM MN CDP-choline phosphohydrolase (ADPRM) DMI4XBM MT DME DMI4XBM MA Metabolism DMI4XBM RN Molecular bases of catalysis and ADP-ribose preference of human Mn2+-dependent ADP-ribose/CDP-alcohol diphosphatase and conversion by mutagenesis to a preferential cyclic ADP-ribose phosphohydrolase. PLoS One. 2015 Feb 18;10(2):e0118680. DMI4XBM RU https://www.ncbi.nlm.nih.gov/pubmed/?term=25692488 DMMEBWR DI DMMEBWR DMMEBWR DN Citric acid, magnesium oxide, sodium picosulfate DMMEBWR MI DEHYDG9 DMMEBWR MN Arylsulfate sulfotransferase (astA) DMMEBWR MT DME DMMEBWR MA Metabolism DMMEBWR RN The role of intestinal bacteria in the transformation of sodium picosulfate. Jpn J Pharmacol. 1992 May;59(1):1-5. DMMEBWR RU https://pubmed.ncbi.nlm.nih.gov/1507649 DM3JDRP DI DM3JDRP DM3JDRP DN Cladribine DM3JDRP MI TTLP57V DM3JDRP MN Adenosine deaminase (ADA) DM3JDRP MT DTT DM3JDRP MA Inhibitor DM3JDRP RN Cladribine: from the bench to the bedside--focus on hairy cell leukemia. Expert Rev Anticancer Ther. 2004 Oct;4(5):745-57. DM3JDRP RU https://pubmed.ncbi.nlm.nih.gov/15485311 DM3JDRP DI DM3JDRP DM3JDRP DN Cladribine DM3JDRP MI DTI7UX6 DM3JDRP MN Breast cancer resistance protein (ABCG2) DM3JDRP MT DTP DM3JDRP MA Substrate DM3JDRP RN Contribution of the drug transporter ABCG2 (breast cancer resistance protein) to resistance against anticancer nucleosides. Mol Cancer Ther. 2008 Sep;7(9):3092-102. DM3JDRP RU http://www.ncbi.nlm.nih.gov/pubmed/18765824 DM3JDRP DI DM3JDRP DM3JDRP DN Cladribine DM3JDRP MI DE9FGNK DM3JDRP MN Deoxycytidine kinase (DCK) DM3JDRP MT DME DM3JDRP MA Metabolism DM3JDRP RN Potential mechanisms of action related to the efficacy and safety of cladribine. Mult Scler Relat Disord. 2019 May;30:176-186. DM3JDRP RU https://www.ncbi.nlm.nih.gov/pubmed/?term=30785074 DM3JDRP DI DM3JDRP DM3JDRP DN Cladribine DM3JDRP MI DTZAWTH DM3JDRP MN Equilibrative nucleoside transporter 3 (SLC29A3) DM3JDRP MT DTP DM3JDRP MA Substrate DM3JDRP RN Functional characterization of novel human and mouse equilibrative nucleoside transporters (hENT3 and mENT3) located in intracellular membranes. J Biol Chem. 2005 Apr 22;280(16):15880-7. DM3JDRP RU http://www.ncbi.nlm.nih.gov/pubmed/15701636 DM3JDRP DI DM3JDRP DM3JDRP DN Cladribine DM3JDRP MI DTCSGPB DM3JDRP MN Multidrug resistance-associated protein 4 (ABCC4) DM3JDRP MT DTP DM3JDRP MA Substrate DM3JDRP RN Human intestinal transporter database: QSAR modeling and virtual profiling of drug uptake, efflux and interactions. Pharm Res. 2013 Apr;30(4):996-1007. DM3JDRP RU https://doi.org/10.1007/s11095-012-0935-x DM3JDRP DI DM3JDRP DM3JDRP DN Cladribine DM3JDRP MI DTT79CX DM3JDRP MN Organic cation transporter 1 (SLC22A1) DM3JDRP MT DTP DM3JDRP MA Substrate DM3JDRP RN Human intestinal transporter database: QSAR modeling and virtual profiling of drug uptake, efflux and interactions. Pharm Res. 2013 Apr;30(4):996-1007. DM3JDRP RU https://doi.org/10.1007/s11095-012-0935-x DM4M1SG DI DM4M1SG DM4M1SG DN Clarithromycin DM4M1SG MI TTUWYEA DM4M1SG MN Bacterial 50S ribosomal RNA (Bact 50S rRNA) DM4M1SG MT DTT DM4M1SG MA Binder DM4M1SG RN Structural basis for the interaction of antibiotics with the peptidyl transferase centre in eubacteria. Nature. 2001 Oct 25;413(6858):814-21. DM4M1SG RU https://pubmed.ncbi.nlm.nih.gov/11677599 DM4M1SG DI DM4M1SG DM4M1SG DN Clarithromycin DM4M1SG MI DE4LYSA DM4M1SG MN Cytochrome P450 3A4 (CYP3A4) DM4M1SG MT DME DM4M1SG MA Metabolism DM4M1SG RN Pharmacokinetic variability of clarithromycin and differences in CYP3A4 activity in patients with cystic fibrosis. J Cyst Fibros. 2014 Mar;13(2):179-85. DM4M1SG RU https://www.ncbi.nlm.nih.gov/pubmed/?term=24035278 DM4M1SG DI DM4M1SG DM4M1SG DN Clarithromycin DM4M1SG MI DEIBDNY DM4M1SG MN Cytochrome P450 3A5 (CYP3A5) DM4M1SG MT DME DM4M1SG MA Metabolism DM4M1SG RN Drug Interactions Flockhart Table DM4M1SG RU https://drug-interactions.medicine.iu.edu/Main-Table.aspx DM4M1SG DI DM4M1SG DM4M1SG DN Clarithromycin DM4M1SG MI DEGTFWK DM4M1SG MN Mephenytoin 4-hydroxylase (CYP2C19) DM4M1SG MT DME DM4M1SG MA Metabolism DM4M1SG RN Influence of CYP2C19 polymorphism and Helicobacter pylori genotype determined from gastric tissue samples on response to triple therapy for H pylori infection. Clin Gastroenterol Hepatol. 2005 Jun;3(6):564-73. DM4M1SG RU https://www.ncbi.nlm.nih.gov/pubmed/?term=15952098 DM4M1SG DI DM4M1SG DM4M1SG DN Clarithromycin DM4M1SG MI DTUGYRD DM4M1SG MN P-glycoprotein 1 (ABCB1) DM4M1SG MT DTP DM4M1SG MA Substrate DM4M1SG RN Mammalian drug efflux transporters of the ATP binding cassette (ABC) family in multidrug resistance: A review of the past decade. Cancer Lett. 2016 Jan 1;370(1):153-64. DM4M1SG RU http://www.ncbi.nlm.nih.gov/pubmed/26499806 DMPGR1E DI DMPGR1E DMPGR1E DN Clascoterone DMPGR1E MI TTS64P2 DMPGR1E MN Androgen receptor (AR) DMPGR1E MT DTT DMPGR1E MA Antagonist DMPGR1E RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health Human Services. 2020 DMPGR1E RU https://www.accessdata.fda.gov/drugsatfda_docs/label/2020/213433s000lbl.pdf DM2FGRT DI DM2FGRT DM2FGRT DN Clavulanate DM2FGRT MI TTHI19T DM2FGRT MN Staphylococcus Beta-lactamase (Stap-coc blaZ) DM2FGRT MT DTT DM2FGRT MA Inhibitor DM2FGRT RN A sensitive coupled HPLC/electrospray mass spectrometry assay for SPM-1 metallo-beta-lactamase inhibitors. Assay Drug Dev Technol. 2009 Apr;7(2):170-9. DM2FGRT RU https://pubmed.ncbi.nlm.nih.gov/19505232 DMBZWQL DI DMBZWQL DMBZWQL DN Clemastine DMBZWQL MI TTTIBOJ DMBZWQL MN Histamine H1 receptor (H1R) DMBZWQL MT DTT DMBZWQL MA Antagonist DMBZWQL RN Histamine upregulates keratinocyte MMP-9 production via the histamine H1 receptor. J Invest Dermatol. 2008 Dec;128(12):2783-91. DMBZWQL RU https://pubmed.ncbi.nlm.nih.gov/18548114 DMCKYZ5 DI DMCKYZ5 DMCKYZ5 DN Clenbuterol DMCKYZ5 MI TT2CJVK DMCKYZ5 MN Adrenergic receptor beta-2 (ADRB2) DMCKYZ5 MT DTT DMCKYZ5 MA Agonist DMCKYZ5 RN Postischemic brain injury is attenuated in mice lacking the beta2-adrenergic receptor. Anesth Analg. 2009 Jan;108(1):280-7. DMCKYZ5 RU https://pubmed.ncbi.nlm.nih.gov/19095863 DMCKYZ5 DI DMCKYZ5 DMCKYZ5 DN Clenbuterol DMCKYZ5 MI DE6OQ3W DMCKYZ5 MN Cytochrome P450 1A1 (CYP1A1) DMCKYZ5 MT DME DMCKYZ5 MA Metabolism DMCKYZ5 RN Beta-adrenergic receptor modulation of the LPS-mediated depression in CYP1A activity in astrocytes. Biochem Pharmacol. 2005 Mar 1;69(5):741-50. DMCKYZ5 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=15710352 DMCKYZ5 DI DMCKYZ5 DMCKYZ5 DN Clenbuterol DMCKYZ5 MI DEJGDUW DMCKYZ5 MN Cytochrome P450 1A2 (CYP1A2) DMCKYZ5 MT DME DMCKYZ5 MA Metabolism DMCKYZ5 RN Beta-adrenergic receptor modulation of the LPS-mediated depression in CYP1A activity in astrocytes. Biochem Pharmacol. 2005 Mar 1;69(5):741-50. DMCKYZ5 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=15710352 DMW4M97 DI DMW4M97 DMW4M97 DN Clevidipine butyrate DMW4M97 MI TT5HONZ DMW4M97 MN Calcium channel unspecific (CaC) DMW4M97 MT DTT DMW4M97 MA Modulator DMW4M97 RN 2008 FDA drug approvals. Nat Rev Drug Discov. 2009 Feb;8(2):93-6. DMW4M97 RU https://pubmed.ncbi.nlm.nih.gov/19180096 DMW4M97 DI DMW4M97 DMW4M97 DN Clevidipine butyrate DMW4M97 MI DECB0K3 DMW4M97 MN Cytochrome P450 2D6 (CYP2D6) DMW4M97 MT DME DMW4M97 MA Metabolism DMW4M97 RN Human cytochrome p450 induction and inhibition potential of clevidipine and its primary metabolite h152/81. Drug Metab Dispos. 2006 May;34(5):734-7. DMW4M97 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=16501008 DMW4M97 DI DMW4M97 DMW4M97 DN Clevidipine butyrate DMW4M97 MI DEVDYN7 DMW4M97 MN Cytochrome P450 2E1 (CYP2E1) DMW4M97 MT DME DMW4M97 MA Metabolism DMW4M97 RN Human cytochrome p450 induction and inhibition potential of clevidipine and its primary metabolite h152/81. Drug Metab Dispos. 2006 May;34(5):734-7. DMW4M97 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=16501008 DMW4M97 DI DMW4M97 DMW4M97 DN Clevidipine butyrate DMW4M97 MI DE4LYSA DMW4M97 MN Cytochrome P450 3A4 (CYP3A4) DMW4M97 MT DME DMW4M97 MA Metabolism DMW4M97 RN Integrated analysis on the physicochemical properties of dihydropyridine calcium channel blockers in grapefruit juice interactions. Curr Pharm Biotechnol. 2012 Jul;13(9):1705-17. DMW4M97 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=22039822 DMW4M97 DI DMW4M97 DMW4M97 DN Clevidipine butyrate DMW4M97 MI TTXHYV6 DMW4M97 MN Voltage-gated L-type calcium channel (L-CaC) DMW4M97 MT DTT DMW4M97 MA Inhibitor DMW4M97 RN Antibodies and venom peptides: new modalities for ion channels. Nat Rev Drug Discov. 2019 May;18(5):339-357. DMW4M97 RU https://pubmed.ncbi.nlm.nih.gov/30728472 DMUMQZ0 DI DMUMQZ0 DMUMQZ0 DN Clidinium DMUMQZ0 MI TTOXS3C DMUMQZ0 MN Muscarinic acetylcholine receptor (CHRM) DMUMQZ0 MT DTT DMUMQZ0 MA Antagonist DMUMQZ0 RN Pharmacological comparison of the cloned human and rat M2 muscarinic receptor genes expressed in the murine fibroblast (B82) cell line. J Pharmacol Exp Ther. 1998 Feb;284(2):500-7. DMUMQZ0 RU https://pubmed.ncbi.nlm.nih.gov/9454790 DMUMQZ0 DI DMUMQZ0 DMUMQZ0 DN Clidinium DMUMQZ0 MI TTZ9SOR DMUMQZ0 MN Muscarinic acetylcholine receptor M1 (CHRM1) DMUMQZ0 MT DTT DMUMQZ0 MA Antagonist DMUMQZ0 RN Accidental acute clidinium toxicity. Emerg Med J. 2009 Jun;26(6):460. DMUMQZ0 RU https://pubmed.ncbi.nlm.nih.gov/19465630 DMUMQZ0 DI DMUMQZ0 DMUMQZ0 DN Clidinium DMUMQZ0 MI DTT79CX DMUMQZ0 MN Organic cation transporter 1 (SLC22A1) DMUMQZ0 MT DTP DMUMQZ0 MA Substrate DMUMQZ0 RN Identification of novel substrates and structure-activity relationship of cellular uptake mediated by human organic cation transporters 1 and 2. J Med Chem. 2013 Sep 26;56(18):7232-42. DMUMQZ0 RU http://www.ncbi.nlm.nih.gov/pubmed/23984907 DM15HL8 DI DM15HL8 DM15HL8 DN Clindamycin DM15HL8 MI TTUWYEA DM15HL8 MN Bacterial 50S ribosomal RNA (Bact 50S rRNA) DM15HL8 MT DTT DM15HL8 MA Binder DM15HL8 RN Structural basis for the interaction of antibiotics with the peptidyl transferase centre in eubacteria. Nature. 2001 Oct 25;413(6858):814-21. DM15HL8 RU https://pubmed.ncbi.nlm.nih.gov/11677599 DM15HL8 DI DM15HL8 DM15HL8 DN Clindamycin DM15HL8 MI DEMSNER DM15HL8 MN Beta-lactamase (blaB) DM15HL8 MT DME DM15HL8 MA Metabolism DM15HL8 RN Comparison of antimicrobial susceptibility, beta-lactamase production, plasmid analysis and serum bactericidal activity in Edwardsiella tarda, E. ictaluri and E. hoshinae. J Med Microbiol. 1993 Oct;39(4):273-81. DM15HL8 RU https://pubmed.ncbi.nlm.nih.gov/8411088 DM15HL8 DI DM15HL8 DM15HL8 DN Clindamycin DM15HL8 MI DE4LYSA DM15HL8 MN Cytochrome P450 3A4 (CYP3A4) DM15HL8 MT DME DM15HL8 MA Metabolism DM15HL8 RN In vitro metabolism of clindamycin in human liver and intestinal microsomes. Drug Metab Dispos. 2003 Jul;31(7):878-87. DM15HL8 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=12814964 DMW1OQ0 DI DMW1OQ0 DMW1OQ0 DN Clobazam - Lundbeck DMW1OQ0 MI DEPKLMQ DMW1OQ0 MN Cytochrome P450 2B6 (CYP2B6) DMW1OQ0 MT DME DMW1OQ0 MA Metabolism DMW1OQ0 RN In vitro characterization of clobazam metabolism by recombinant cytochrome P450 enzymes: importance of CYP2C19. Drug Metab Dispos. 2004 Nov;32(11):1279-86. DMW1OQ0 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=15483195 DMW1OQ0 DI DMW1OQ0 DMW1OQ0 DN Clobazam - Lundbeck DMW1OQ0 MI DEZMWRE DMW1OQ0 MN Cytochrome P450 2C18 (CYP2C18) DMW1OQ0 MT DME DMW1OQ0 MA Metabolism DMW1OQ0 RN In vitro characterization of clobazam metabolism by recombinant cytochrome P450 enzymes: importance of CYP2C19. Drug Metab Dispos. 2004 Nov;32(11):1279-86. DMW1OQ0 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=15483195 DMW1OQ0 DI DMW1OQ0 DMW1OQ0 DN Clobazam - Lundbeck DMW1OQ0 MI DE4LYSA DMW1OQ0 MN Cytochrome P450 3A4 (CYP3A4) DMW1OQ0 MT DME DMW1OQ0 MA Metabolism DMW1OQ0 RN In vitro characterization of clobazam metabolism by recombinant cytochrome P450 enzymes: importance of CYP2C19. Drug Metab Dispos. 2004 Nov;32(11):1279-86. DMW1OQ0 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=15483195 DMW1OQ0 DI DMW1OQ0 DMW1OQ0 DN Clobazam - Lundbeck DMW1OQ0 MI TT1MPAY DMW1OQ0 MN GABA(A) receptor alpha-1 (GABRA1) DMW1OQ0 MT DTT DMW1OQ0 MA Antagonist DMW1OQ0 RN DrugBank: a knowledgebase for drugs, drug actions and drug targets. Nucleic Acids Res. 2008 Jan;36(Database issue):D901-6. DMW1OQ0 RU https://pubmed.ncbi.nlm.nih.gov/18048412 DMW1OQ0 DI DMW1OQ0 DMW1OQ0 DN Clobazam - Lundbeck DMW1OQ0 MI TTEX6LM DMW1OQ0 MN GABA(A) receptor gamma-3 (GABRG3) DMW1OQ0 MT DTT DMW1OQ0 MA Modulator DMW1OQ0 RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. DMW1OQ0 RU https://www.fda.gov/ DMW1OQ0 DI DMW1OQ0 DMW1OQ0 DN Clobazam - Lundbeck DMW1OQ0 MI DEGTFWK DMW1OQ0 MN Mephenytoin 4-hydroxylase (CYP2C19) DMW1OQ0 MT DME DMW1OQ0 MA Metabolism DMW1OQ0 RN A major influence of CYP2C19 genotype on the steady-state concentration of N-desmethylclobazam. Brain Dev. 2004 Dec;26(8):530-4. DMW1OQ0 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=15533655 DMW1OQ0 DI DMW1OQ0 DMW1OQ0 DN Clobazam - Lundbeck DMW1OQ0 MI DTUGYRD DMW1OQ0 MN P-glycoprotein 1 (ABCB1) DMW1OQ0 MT DTP DMW1OQ0 MA Substrate DMW1OQ0 RN Tarascon Pocket Pharmacopoeia 2018 Classic Shirt-Pocket Edition. DMW1OQ0 RU https://books.google.com/books?id=0gBRDwAAQBAJ&pg=PP37&lpg=PP37&dq=Methylergonovine+transporter+uptake+efflex&source=bl&ots=cUTe_ppsmZ&sig=ACfU3U3E_YqrDg0CNEuj8K-7lci47HAnrg&hl=zh-CN&sa=X&ved=2ahUKEwjnj-Dk7d7iAhUsK6YKHd5DBDkQ6AEwEnoECAgQAQ#v=onepage&q&f=false DMUXP52 DI DMUXP52 DMUXP52 DN Clobetasol DMUXP52 MI TT9V5JH DMUXP52 MN Phospholipase A2 (PLA2G1B) DMUXP52 MT DTT DMUXP52 MA Inhibitor DMUXP52 RN Utilization of epidermal phospholipase A2 inhibition to monitor topical steroid action. Br J Dermatol. 1984 Jul;111 Suppl 27:195-203. DMUXP52 RU https://pubmed.ncbi.nlm.nih.gov/6743552 DM9ZMQH DI DM9ZMQH DM9ZMQH DN Clocortolone DM9ZMQH MI TT9V5JH DM9ZMQH MN Phospholipase A2 (PLA2G1B) DM9ZMQH MT DTT DM9ZMQH MA Inducer DM9ZMQH RN Clocortolone pivalate: a paired comparison clinical trial of a new topical steroid in eczema/atopic dermatitis. Cutis. 1980 Jan;25(1):96-8. DM9ZMQH RU https://pubmed.ncbi.nlm.nih.gov/6986236 DM9Y6X7 DI DM9Y6X7 DM9Y6X7 DN Clodronate DM9Y6X7 MI TTU5A6Q DM9Y6X7 MN Adenine nucleotide translocator 1 (SLC25A4) DM9Y6X7 MT DTT DM9Y6X7 MA Inhibitor DM9Y6X7 RN Further insight into mechanism of action of clodronate: inhibition of mitochondrial ADP/ATP translocase by a nonhydrolyzable, adenine-containing metabolite. Mol Pharmacol. 2002 May;61(5):1255-62. DM9Y6X7 RU https://pubmed.ncbi.nlm.nih.gov/11961144 DMCVJ86 DI DMCVJ86 DMCVJ86 DN Clofarabine DMCVJ86 MI TTJP4SM DMCVJ86 MN Bacterial Penicillin binding protein (Bact PBP) DMCVJ86 MT DTT DMCVJ86 MA Binder DMCVJ86 RN Clofarabine: past, present, and future. Leuk Lymphoma. 2007 Oct;48(10):1922-30. DMCVJ86 RU https://pubmed.ncbi.nlm.nih.gov/17852710 DMCVJ86 DI DMCVJ86 DMCVJ86 DN Clofarabine DMCVJ86 MI DTI7UX6 DMCVJ86 MN Breast cancer resistance protein (ABCG2) DMCVJ86 MT DTP DMCVJ86 MA Substrate DMCVJ86 RN Contribution of the drug transporter ABCG2 (breast cancer resistance protein) to resistance against anticancer nucleosides. Mol Cancer Ther. 2008 Sep;7(9):3092-102. DMCVJ86 RU http://www.ncbi.nlm.nih.gov/pubmed/18765824 DMCVJ86 DI DMCVJ86 DMCVJ86 DN Clofarabine DMCVJ86 MI DT4YL5R DMCVJ86 MN Concentrative Na(+)-nucleoside cotransporter 3 (SLC28A3) DMCVJ86 MT DTP DMCVJ86 MA Substrate DMCVJ86 RN Cytarabine-resistant leukemia cells are moderately sensitive to clofarabine in vitro. Anticancer Res. 2014 Apr;34(4):1657-62. DMCVJ86 RU http://www.ncbi.nlm.nih.gov/pubmed/24692694 DMCVJ86 DI DMCVJ86 DMCVJ86 DN Clofarabine DMCVJ86 MI DE9FGNK DMCVJ86 MN Deoxycytidine kinase (DCK) DMCVJ86 MT DME DMCVJ86 MA Metabolism DMCVJ86 RN FDA label of Belinostat. The 2020 official website of the U.S. Food and Drug Administration. DMCVJ86 RU https://www.accessdata.fda.gov/drugsatfda_docs/label/2015/021673s024lbl.pdf DMCVJ86 DI DMCVJ86 DMCVJ86 DN Clofarabine DMCVJ86 MI DTXD1TQ DMCVJ86 MN Equilibrative nucleoside transporter 1 (SLC29A1) DMCVJ86 MT DTP DMCVJ86 MA Substrate DMCVJ86 RN Cytarabine-resistant leukemia cells are moderately sensitive to clofarabine in vitro. Anticancer Res. 2014 Apr;34(4):1657-62. DMCVJ86 RU http://www.ncbi.nlm.nih.gov/pubmed/24692694 DMCVJ86 DI DMCVJ86 DMCVJ86 DN Clofarabine DMCVJ86 MI DTW78DQ DMCVJ86 MN Equilibrative nucleoside transporter 2 (SLC29A2) DMCVJ86 MT DTP DMCVJ86 MA Substrate DMCVJ86 RN Cytarabine-resistant leukemia cells are moderately sensitive to clofarabine in vitro. Anticancer Res. 2014 Apr;34(4):1657-62. 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DMINRKW RU https://doi.org/10.1016/j.addr.2011.12.008 DMINRKW DI DMINRKW DMINRKW DN Clomipramine DMINRKW MI TT3ROYC DMINRKW MN Serotonin transporter (SERT) DMINRKW MT DTT DMINRKW MA Inhibitor DMINRKW RN Efficacy of treatments for patients with obsessive-compulsive disorder: a systematic review. J Am Acad Nurse Pract. 2009 Apr;21(4):207-13. DMINRKW RU https://pubmed.ncbi.nlm.nih.gov/19366379 DM0ZRMQ DI DM0ZRMQ DM0ZRMQ DN Clomocycline DM0ZRMQ MI TTQ8KVI DM0ZRMQ MN Staphylococcus 30S ribosomal subunit (Stap-coc pbp2) DM0ZRMQ MT DTT DM0ZRMQ MA Binder DM0ZRMQ RN Molecular dynamics simulations of the 30S ribosomal subunit reveal a preferred tetracycline binding site. J Am Chem Soc. 2008 Jan 30;130(4):1114-5. DM0ZRMQ RU https://pubmed.ncbi.nlm.nih.gov/18219717 DMTO13J DI DMTO13J DMTO13J DN Clonazepam DMTO13J MI DE4LYSA DMTO13J MN Cytochrome P450 3A4 (CYP3A4) DMTO13J MT DME DMTO13J MA Metabolism DMTO13J RN Identification of the human and animal hepatic cytochromes P450 involved in clonazepam metabolism. Fundam Clin Pharmacol. 1993;7(2):69-75. DMTO13J RU https://www.ncbi.nlm.nih.gov/pubmed/?term=8486332 DMTO13J DI DMTO13J DMTO13J DN Clonazepam DMTO13J MI TTNJYV2 DMTO13J MN Gamma-aminobutyric acid receptor (GAR) DMTO13J MT DTT DMTO13J MA Agonist DMTO13J RN Glutamate- and GABA-based CNS therapeutics. Curr Opin Pharmacol. 2006 Feb;6(1):7-17. DMTO13J RU https://pubmed.ncbi.nlm.nih.gov/16377242 DMTO13J DI DMTO13J DMTO13J DN Clonazepam DMTO13J MI DE0QLUZ DMTO13J MN Oxygen-insensitive NADPH nitroreductase B (nfsB) DMTO13J MT DME DMTO13J MA Metabolism DMTO13J RN Characterization of Escherichia coli nitroreductase NfsB in the metabolism of nitrobenzodiazepines. 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DM6RZ9Q RU https://pubmed.ncbi.nlm.nih.gov/11164065 DM6RZ9Q DI DM6RZ9Q DM6RZ9Q DN Clonidine DM6RZ9Q MI DEJGDUW DM6RZ9Q MN Cytochrome P450 1A2 (CYP1A2) DM6RZ9Q MT DME DM6RZ9Q MA Metabolism DM6RZ9Q RN CYP2D6 mediates 4-hydroxylation of clonidine in vitro: implication for pregnancy-induced changes in clonidine clearance. Drug Metab Dispos. 2010 Sep;38(9):1393-6. DM6RZ9Q RU https://www.ncbi.nlm.nih.gov/pubmed/?term=20570945 DM6RZ9Q DI DM6RZ9Q DM6RZ9Q DN Clonidine DM6RZ9Q MI DECB0K3 DM6RZ9Q MN Cytochrome P450 2D6 (CYP2D6) DM6RZ9Q MT DME DM6RZ9Q MA Metabolism DM6RZ9Q RN CYP2D6 mediates 4-hydroxylation of clonidine in vitro: implication for pregnancy-induced changes in clonidine clearance. Drug Metab Dispos. 2010 Sep;38(9):1393-6. DM6RZ9Q RU https://www.ncbi.nlm.nih.gov/pubmed/?term=20570945 DM6RZ9Q DI DM6RZ9Q DM6RZ9Q DN Clonidine DM6RZ9Q MI DE4LYSA DM6RZ9Q MN Cytochrome P450 3A4 (CYP3A4) DM6RZ9Q MT DME DM6RZ9Q MA Metabolism DM6RZ9Q RN CYP2D6 mediates 4-hydroxylation of clonidine in vitro: implication for pregnancy-induced changes in clonidine clearance. Drug Metab Dispos. 2010 Sep;38(9):1393-6. DM6RZ9Q RU https://www.ncbi.nlm.nih.gov/pubmed/?term=20570945 DM6RZ9Q DI DM6RZ9Q DM6RZ9Q DN Clonidine DM6RZ9Q MI DEIBDNY DM6RZ9Q MN Cytochrome P450 3A5 (CYP3A5) DM6RZ9Q MT DME DM6RZ9Q MA Metabolism DM6RZ9Q RN CYP2D6 mediates 4-hydroxylation of clonidine in vitro: implication for pregnancy-induced changes in clonidine clearance. Drug Metab Dispos. 2010 Sep;38(9):1393-6. DM6RZ9Q RU https://www.ncbi.nlm.nih.gov/pubmed/?term=20570945 DM6RZ9Q DI DM6RZ9Q DM6RZ9Q DN Clonidine DM6RZ9Q MI TT7HC21 DM6RZ9Q MN Membrane copper amine oxidase (AOC3) DM6RZ9Q MT DTT DM6RZ9Q MA Inhibitor DM6RZ9Q RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DM6RZ9Q RU https://pubmed.ncbi.nlm.nih.gov/10592235 DM6RZ9Q DI DM6RZ9Q DM6RZ9Q DN Clonidine DM6RZ9Q MI DTT79CX DM6RZ9Q MN Organic cation transporter 1 (SLC22A1) DM6RZ9Q MT DTP DM6RZ9Q MA Substrate DM6RZ9Q RN Influx Transport of Cationic Drug at the Blood-Retinal Barrier: Impact on the Retinal Delivery of Neuroprotectants. Biol Pharm Bull. 2017;40(8):1139-1145. DM6RZ9Q RU http://www.ncbi.nlm.nih.gov/pubmed/28768994 DM6RZ9Q DI DM6RZ9Q DM6RZ9Q DN Clonidine DM6RZ9Q MI DT9IDPW DM6RZ9Q MN Organic cation transporter 2 (SLC22A2) DM6RZ9Q MT DTP DM6RZ9Q MA Substrate DM6RZ9Q RN Influx Transport of Cationic Drug at the Blood-Retinal Barrier: Impact on the Retinal Delivery of Neuroprotectants. Biol Pharm Bull. 2017;40(8):1139-1145. DM6RZ9Q RU http://www.ncbi.nlm.nih.gov/pubmed/28768994 DM6RZ9Q DI DM6RZ9Q DM6RZ9Q DN Clonidine DM6RZ9Q MI DT6201N DM6RZ9Q MN Organic cation transporter 3 (SLC22A3) DM6RZ9Q MT DTP DM6RZ9Q MA Substrate DM6RZ9Q RN Influx Transport of Cationic Drug at the Blood-Retinal Barrier: Impact on the Retinal Delivery of Neuroprotectants. Biol Pharm Bull. 2017;40(8):1139-1145. DM6RZ9Q RU http://www.ncbi.nlm.nih.gov/pubmed/28768994 DM6RZ9Q DI DM6RZ9Q DM6RZ9Q DN Clonidine DM6RZ9Q MI DTUGYRD DM6RZ9Q MN P-glycoprotein 1 (ABCB1) DM6RZ9Q MT DTP DM6RZ9Q MA Substrate DM6RZ9Q RN Caco-2 permeability, P-glycoprotein transport ratios and brain penetration of heterocyclic drugs. Int J Pharm. 2003 Sep 16;263(1-2):113-22. DM6RZ9Q RU http://www.ncbi.nlm.nih.gov/pubmed/12954186 DMOL54H DI DMOL54H DMOL54H DN Clopidogrel DMOL54H MI DEJGDUW DMOL54H MN Cytochrome P450 1A2 (CYP1A2) DMOL54H MT DME DMOL54H MA Metabolism DMOL54H RN Clinical pharmacokinetics and pharmacodynamics of clopidogrel. 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DMOL54H RU https://www.ncbi.nlm.nih.gov/pubmed/?term=17361128 DMOL54H DI DMOL54H DMOL54H DN Clopidogrel DMOL54H MI DE4LYSA DMOL54H MN Cytochrome P450 3A4 (CYP3A4) DMOL54H MT DME DMOL54H MA Metabolism DMOL54H RN Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. DMOL54H RU https://www.ncbi.nlm.nih.gov/pubmed/?term=19515014 DMOL54H DI DMOL54H DMOL54H DN Clopidogrel DMOL54H MI DEIBDNY DMOL54H MN Cytochrome P450 3A5 (CYP3A5) DMOL54H MT DME DMOL54H MA Metabolism DMOL54H RN Cytochrome P450 3A inhibition by ketoconazole affects prasugrel and clopidogrel pharmacokinetics and pharmacodynamics differently. Clin Pharmacol Ther. 2007 May;81(5):735-41. DMOL54H RU https://www.ncbi.nlm.nih.gov/pubmed/?term=17361128 DMOL54H DI DMOL54H DMOL54H DN Clopidogrel DMOL54H MI DEGTFWK DMOL54H MN Mephenytoin 4-hydroxylase (CYP2C19) DMOL54H MT DME DMOL54H MA Metabolism DMOL54H RN Impact of the CYP2C19 gene polymorphism on clopidogrel personalized drug regimen and the clinical outcomes. Clin Lab. 2016 Sep 1;62(9):1773-1780. DMOL54H RU https://www.ncbi.nlm.nih.gov/pubmed/?term=28164572 DMOL54H DI DMOL54H DMOL54H DN Clopidogrel DMOL54H MI TTZ1DT0 DMOL54H MN P2Y purinoceptor 12 (P2RY12) DMOL54H MT DTT DMOL54H MA Antagonist DMOL54H RN P2Y12, a new platelet ADP receptor, target of clopidogrel. Semin Vasc Med. 2003 May;3(2):113-22. DMOL54H RU https://pubmed.ncbi.nlm.nih.gov/15199474 DMOL54H DI DMOL54H DMOL54H DN Clopidogrel DMOL54H MI DTUGYRD DMOL54H MN P-glycoprotein 1 (ABCB1) DMOL54H MT DTP DMOL54H MA Substrate DMOL54H RN Impact of P-glycoprotein on clopidogrel absorption. Clin Pharmacol Ther. 2006 Nov;80(5):486-501. DMOL54H RU http://www.ncbi.nlm.nih.gov/pubmed/17112805 DMC3JST DI DMC3JST DMC3JST DN Clorazepate DMC3JST MI DE4LYSA DMC3JST MN Cytochrome P450 3A4 (CYP3A4) DMC3JST MT DME DMC3JST MA Metabolism DMC3JST RN In vitro drug allergy detection system incorporating human liver microsomes in chlorazepate-induced skin rash: drug-specific proliferation associated with interleukin-5 secretion. Br J Dermatol. 2001 Feb;144(2):316-20. DMC3JST RU https://www.ncbi.nlm.nih.gov/pubmed/?term=11251565 DMC3JST DI DMC3JST DMC3JST DN Clorazepate DMC3JST MI TTPTXIN DMC3JST MN Translocator protein (TSPO) DMC3JST MT DTT DMC3JST MA Modulator DMC3JST RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. DMC3JST RU https://www.fda.gov/ DMCEUJD DI DMCEUJD DMCEUJD DN Clorgyline DMCEUJD MI TT32XQJ DMCEUJD MN Monoamine oxidase (MAO) DMCEUJD MT DTT DMCEUJD MA Inhibitor DMCEUJD RN Novel monoamine oxidase inhibitors: a patent review (2012 - 2014).Expert Opin Ther Pat. 2015 Jan;25(1):91-110. DMCEUJD RU https://www.ncbi.nlm.nih.gov/pubmed/25399762 DMCEUJD DI DMCEUJD DMCEUJD DN Clorgyline DMCEUJD MI TT3WG5C DMCEUJD MN Monoamine oxidase type A (MAO-A) DMCEUJD MT DTT DMCEUJD MA Inhibitor DMCEUJD RN Further investigation into the mechanism of tachykinin NK(2) receptor-triggered serotonin release from guinea-pig proximal colon. J Pharmacol Sci. 2009 May;110(1):122-6. DMCEUJD RU https://pubmed.ncbi.nlm.nih.gov/19423952 DM6K1OA DI DM6K1OA DM6K1OA DN Clothiapine DM6K1OA MI DERD86B DM6K1OA MN Cytochrome P450 3A7 (CYP3A7) DM6K1OA MT DME DM6K1OA MA Metabolism DM6K1OA RN Biotransformation of post-clozapine antipsychotics: pharmacological implications. Clin Pharmacokinet. 2000 May;38(5):393-414. DM6K1OA RU https://www.ncbi.nlm.nih.gov/pubmed/?term=10843459 DM59AZT DI DM59AZT DM59AZT DN Clotiazepam DM59AZT MI DEPKLMQ DM59AZT MN Cytochrome P450 2B6 (CYP2B6) DM59AZT MT DME DM59AZT MA Metabolism DM59AZT RN Contribution of human hepatic cytochrome p450 isoforms to the metabolism of psychotropic drugs. Biol Pharm Bull. 2005 Sep;28(9):1711-6. DM59AZT RU https://www.ncbi.nlm.nih.gov/pubmed/?term=16141545 DM59AZT DI DM59AZT DM59AZT DN Clotiazepam DM59AZT MI DEZMWRE DM59AZT MN Cytochrome P450 2C18 (CYP2C18) DM59AZT MT DME DM59AZT MA Metabolism DM59AZT RN Contribution of human hepatic cytochrome p450 isoforms to the metabolism of psychotropic drugs. Biol Pharm Bull. 2005 Sep;28(9):1711-6. DM59AZT RU https://www.ncbi.nlm.nih.gov/pubmed/?term=16141545 DM59AZT DI DM59AZT DM59AZT DN Clotiazepam DM59AZT MI DE4LYSA DM59AZT MN Cytochrome P450 3A4 (CYP3A4) DM59AZT MT DME DM59AZT MA Metabolism DM59AZT RN Contribution of human hepatic cytochrome p450 isoforms to the metabolism of psychotropic drugs. Biol Pharm Bull. 2005 Sep;28(9):1711-6. DM59AZT RU https://www.ncbi.nlm.nih.gov/pubmed/?term=16141545 DM59AZT DI DM59AZT DM59AZT DN Clotiazepam DM59AZT MI DEGTFWK DM59AZT MN Mephenytoin 4-hydroxylase (CYP2C19) DM59AZT MT DME DM59AZT MA Metabolism DM59AZT RN Contribution of human hepatic cytochrome p450 isoforms to the metabolism of psychotropic drugs. Biol Pharm Bull. 2005 Sep;28(9):1711-6. DM59AZT RU https://www.ncbi.nlm.nih.gov/pubmed/?term=16141545 DM59AZT DI DM59AZT DM59AZT DN Clotiazepam DM59AZT MI TTPTXIN DM59AZT MN Translocator protein (TSPO) DM59AZT MT DTT DM59AZT MA Agonist DM59AZT RN Effects of benzodiazepines and non-benzodiazepine compounds on the GABA-induced response in frog isolated sensory neurones. Br J Pharmacol. 1989 Nov;98(3):735-40. DM59AZT RU https://pubmed.ncbi.nlm.nih.gov/2574062 DMMFCIH DI DMMFCIH DMMFCIH DN Clotrimazole DMMFCIH MI TT30C9G DMMFCIH MN C-X-C chemokine receptor type 2 (CXCR2) DMMFCIH MT DTT DMMFCIH MA Modulator DMMFCIH RN Mode of action of clotrimazole: implications for therapy. Am J Obstet Gynecol. 1985 Aug 1;152(7 Pt 2):939-44. DMMFCIH RU https://www.ncbi.nlm.nih.gov/pubmed/3895959 DMMFCIH DI DMMFCIH DMMFCIH DN Clotrimazole DMMFCIH MI DE4LYSA DMMFCIH MN Cytochrome P450 3A4 (CYP3A4) DMMFCIH MT DME DMMFCIH MA Metabolism DMMFCIH RN Tacrolimus interaction with clotrimazole: a concise case report and literature review. 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Naunyn Schmiedebergs Arch Pharmacol. 1998 Nov;358(5):592-9. DMFC71L RU https://www.ncbi.nlm.nih.gov/pubmed/?term=9840430 DMFC71L DI DMFC71L DMFC71L DN Clozapine DMFC71L MI DECB0K3 DMFC71L MN Cytochrome P450 2D6 (CYP2D6) DMFC71L MT DME DMFC71L MA Metabolism DMFC71L RN Effect of antipsychotic drugs on human liver cytochrome P-450 (CYP) isoforms in vitro: preferential inhibition of CYP2D6. Drug Metab Dispos. 1999 Sep;27(9):1078-84. DMFC71L RU https://www.ncbi.nlm.nih.gov/pubmed/?term=10460810 DMFC71L DI DMFC71L DMFC71L DN Clozapine DMFC71L MI DE4LYSA DMFC71L MN Cytochrome P450 3A4 (CYP3A4) DMFC71L MT DME DMFC71L MA Metabolism DMFC71L RN Drug metabolism and atypical antipsychotics. Eur Neuropsychopharmacol. 1999 Jun;9(4):301-9. DMFC71L RU https://www.ncbi.nlm.nih.gov/pubmed/?term=10422890 DMFC71L DI DMFC71L DMFC71L DN Clozapine DMFC71L MI TTE0A2F DMFC71L MN Dopamine D4 receptor (D4R) DMFC71L MT DTT DMFC71L MA Modulator DMFC71L RN Drugs@FDA. U.S. Food and Drug Administration. 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The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7535). DM6L4H2 RU http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=7535 DM6L4H2 DI DM6L4H2 DM6L4H2 DN Cobicistat DM6L4H2 MI DE4LYSA DM6L4H2 MN Cytochrome P450 3A4 (CYP3A4) DM6L4H2 MT DME DM6L4H2 MA Metabolism DM6L4H2 RN Drug interactions between hormonal contraceptives and antiretrovirals. AIDS. 2017 Apr 24;31(7):917-952. DM6L4H2 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=28060009 DM6L4H2 DI DM6L4H2 DM6L4H2 DN Cobicistat DM6L4H2 MI DEIBDNY DM6L4H2 MN Cytochrome P450 3A5 (CYP3A5) DM6L4H2 MT DME DM6L4H2 MA Metabolism DM6L4H2 RN Pharmacokinetics and pharmacodynamics of GS-9350: a novel pharmacokinetic enhancer without anti-HIV activity. Clin Pharmacol Ther. 2010 Mar;87(3):322-9. DM6L4H2 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=20043009 DM6L4H2 DI DM6L4H2 DM6L4H2 DN Cobicistat DM6L4H2 MI DERD86B DM6L4H2 MN Cytochrome P450 3A7 (CYP3A7) DM6L4H2 MT DME DM6L4H2 MA Metabolism DM6L4H2 RN Pharmacokinetics and pharmacodynamics of GS-9350: a novel pharmacokinetic enhancer without anti-HIV activity. Clin Pharmacol Ther. 2010 Mar;87(3):322-9. DM6L4H2 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=20043009 DMDKXTO DI DMDKXTO DMDKXTO DN Cobicistat/darunavir DMDKXTO MI TTIJQ3O DMDKXTO MN Cytochrome P450 3A (CYP3A) DMDKXTO MT DTT DMDKXTO MA Modulator DMDKXTO RN Cobicistat: a review of its use as a pharmacokinetic enhancer of atazanavir and darunavir in patients with HIV-1 infection. Drugs. 2014 Feb;74(2):195-206. 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DMJX6ZG RU https://www.ncbi.nlm.nih.gov/pubmed/?term=19817501 DMJX6ZG DI DMJX6ZG DMJX6ZG DN Codeine DMJX6ZG MI DE4LYSA DMJX6ZG MN Cytochrome P450 3A4 (CYP3A4) DMJX6ZG MT DME DMJX6ZG MA Metabolism DMJX6ZG RN Drug-drug interactions for UDP-glucuronosyltransferase substrates: a pharmacokinetic explanation for typically observed low exposure (AUCi/AUC) ratios. Drug Metab Dispos. 2004 Nov;32(11):1201-8. DMJX6ZG RU https://www.ncbi.nlm.nih.gov/pubmed/?term=15304429 DMJX6ZG DI DMJX6ZG DMJX6ZG DN Codeine DMJX6ZG MI DERD86B DMJX6ZG MN Cytochrome P450 3A7 (CYP3A7) DMJX6ZG MT DME DMJX6ZG MA Metabolism DMJX6ZG RN Summary of information on human CYP enzymes: human P450 metabolism data. Drug Metab Rev. 2002 Feb-May;34(1-2):83-448. DMJX6ZG RU https://www.ncbi.nlm.nih.gov/pubmed/?term=11996015 DMJX6ZG DI DMJX6ZG DMJX6ZG DN Codeine DMJX6ZG MI TT27RFC DMJX6ZG MN Opioid receptor delta (OPRD1) DMJX6ZG MT DTT DMJX6ZG MA Agonist DMJX6ZG RN Butorphanol: effects of a prototypical agonist-antagonist analgesic on kappa-opioid receptors. J Pharmacol Sci. 2005 Jun;98(2):109-16. DMJX6ZG RU https://pubmed.ncbi.nlm.nih.gov/15942128 DMJX6ZG DI DMJX6ZG DMJX6ZG DN Codeine DMJX6ZG MI DTT79CX DMJX6ZG MN Organic cation transporter 1 (SLC22A1) DMJX6ZG MT DTP DMJX6ZG MA Substrate DMJX6ZG RN Association of Organic Cation Transporter 1 With Intolerance to Metformin in Type 2 Diabetes: A GoDARTS Study. Diabetes. 2015 May;64(5):1786-93. 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DM2POTE RU https://www.ncbi.nlm.nih.gov/pubmed/?term=12815172 DM2POTE DI DM2POTE DM2POTE DN Colchicine DM2POTE MI DTSYQGK DM2POTE MN Multidrug resistance-associated protein 1 (ABCC1) DM2POTE MT DTP DM2POTE MA Substrate DM2POTE RN Pharmacological characterization of the murine and human orthologs of multidrug-resistance protein in transfected human embryonic kidney cells. Mol Pharmacol. 1997 Sep;52(3):344-53. DM2POTE RU http://molpharm.aspetjournals.org/content/52/3/344 DM2POTE DI DM2POTE DM2POTE DN Colchicine DM2POTE MI DTUGYRD DM2POTE MN P-glycoprotein 1 (ABCB1) DM2POTE MT DTP DM2POTE MA Substrate DM2POTE RN Nilotinib (AMN107, Tasigna) reverses multidrug resistance by inhibiting the activity of the ABCB1/Pgp and ABCG2/BCRP/MXR transporters. Biochem Pharmacol. 2009 Jul 15;78(2):153-61. DM2POTE RU http://www.ncbi.nlm.nih.gov/pubmed/19427995 DM2POTE DI DM2POTE DM2POTE DN Colchicine DM2POTE MI TTML2WA DM2POTE MN Tubulin (TUB) DM2POTE MT DTT DM2POTE MA Binder DM2POTE RN Vitamin K3 disrupts the microtubule networks by binding to tubulin: a novel mechanism of its antiproliferative activity. Biochemistry. 2009 Jul 28;48(29):6963-74. DM2POTE RU https://pubmed.ncbi.nlm.nih.gov/19527023 DMJ01D8 DI DMJ01D8 DMJ01D8 DN Colforsin daropate hci DMJ01D8 MI TTULOB6 DMJ01D8 MN Cathelicidin antimicrobial peptide (CAMP) DMJ01D8 MT DTT DMJ01D8 MA Modulator DMJ01D8 RN Natural products as sources of new drugs over the last 25 years. J Nat Prod. 2007 Mar;70(3):461-77. DMJ01D8 RU https://pubmed.ncbi.nlm.nih.gov/17309302 DMZ9BMU DI DMZ9BMU DMZ9BMU DN Colistimethate DMZ9BMU MI TT4ILYC DMZ9BMU MN Bacterial Dihydropteroate synthetase (Bact folP) DMZ9BMU MT DTT DMZ9BMU MA Binder DMZ9BMU RN Polymyxin B sulfate and colistin: old antibiotics for emerging multiresistant gram-negative bacteria. Ann Pharmacother. 1999 Sep;33(9):960-7. DMZ9BMU RU https://pubmed.ncbi.nlm.nih.gov/10492501 DMMD9QE DI DMMD9QE DMMD9QE DN Colistin DMMD9QE MI TT4ILYC DMMD9QE MN Bacterial Dihydropteroate synthetase (Bact folP) DMMD9QE MT DTT DMMD9QE MA Binder DMMD9QE RN Polymyxin B sulfate and colistin: old antibiotics for emerging multiresistant gram-negative bacteria. Ann Pharmacother. 1999 Sep;33(9):960-7. DMMD9QE RU https://pubmed.ncbi.nlm.nih.gov/10492501 DMMD9QE DI DMMD9QE DMMD9QE DN Colistin DMMD9QE MI DE2M583 DMMD9QE MN Endoglucanase Y (EGY) DMMD9QE MT DME DMMD9QE MA Metabolism DMMD9QE RN Expression of Clostridium thermocellum endoglucanase gene in Lactobacillus gasseri and Lactobacillus johnsonii and characterization of the genetically modified probiotic lactobacilli. Curr Microbiol. 2000 Apr;40(4):257-63. DMMD9QE RU https://pubmed.ncbi.nlm.nih.gov/10688695 DMMD9QE DI DMMD9QE DMMD9QE DN Colistin DMMD9QE MI DE2AZTG DMMD9QE MN Endoglucanase Y (EGY) DMMD9QE MT DME DMMD9QE MA Metabolism DMMD9QE RN Expression of Clostridium thermocellum endoglucanase gene in Lactobacillus gasseri and Lactobacillus johnsonii and characterization of the genetically modified probiotic lactobacilli. Curr Microbiol. 2000 Apr;40(4):257-63. DMMD9QE RU https://pubmed.ncbi.nlm.nih.gov/10688695 DMFJ2OG DI DMFJ2OG DMFJ2OG DN Collagenase DMFJ2OG MI TTK982E DMFJ2OG MN Collagen (CO) DMFJ2OG MT DTT DMFJ2OG MA Breaker DMFJ2OG RN Contact dermatitis with clostridiopeptidase A contained in Noruxol ointment. Contact Dermatitis. 2007 Jun;56(6):361-2. DMFJ2OG RU https://pubmed.ncbi.nlm.nih.gov/17577383 DM1V329 DI DM1V329 DM1V329 DN Conivaptan DM1V329 MI DE4LYSA DM1V329 MN Cytochrome P450 3A4 (CYP3A4) DM1V329 MT DME DM1V329 MA Metabolism DM1V329 RN Conivaptan: a dual vasopressin receptor v1a/v2 antagonist [corrected]. Cardiovasc Drug Rev. 2007 Fall;25(3):261-79. DM1V329 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=17919259 DM1V329 DI DM1V329 DM1V329 DN Conivaptan DM1V329 MI TT4TFGN DM1V329 MN Vasopressin V1a receptor (V1AR) DM1V329 MT DTT DM1V329 MA Modulator DM1V329 RN Acute hemodynamic effects of conivaptan, a dual V(1A) and V(2) vasopressin receptor antagonist, in patients with advanced heart failure. Circulation. 2001 Nov 13;104(20):2417-23. DM1V329 RU https://pubmed.ncbi.nlm.nih.gov/11705818 DM1V329 DI DM1V329 DM1V329 DN Conivaptan DM1V329 MI TTK8R02 DM1V329 MN Vasopressin V2 receptor (V2R) DM1V329 MT DTT DM1V329 MA Modulator DM1V329 RN Acute hemodynamic effects of conivaptan, a dual V(1A) and V(2) vasopressin receptor antagonist, in patients with advanced heart failure. Circulation. 2001 Nov 13;104(20):2417-23. DM1V329 RU https://pubmed.ncbi.nlm.nih.gov/11705818 DMLT0E1 DI DMLT0E1 DMLT0E1 DN Conjugated estrogens DMLT0E1 MI DE9RA0I DMLT0E1 MN Beta-glucuronidase (uidA) DMLT0E1 MT DME DMLT0E1 MA Metabolism DMLT0E1 RN Long-term administration of conjugated estrogen and bazedoxifene decreased murine fecal beta-glucuronidase activity without impacting overall microbiome community. Sci Rep. 2018 May 25;8(1):8166. DMLT0E1 RU https://pubmed.ncbi.nlm.nih.gov/29802368 DMLT0E1 DI DMLT0E1 DMLT0E1 DN Conjugated estrogens DMLT0E1 MI DEJGDUW DMLT0E1 MN Cytochrome P450 1A2 (CYP1A2) DMLT0E1 MT DME DMLT0E1 MA Metabolism DMLT0E1 RN Effect of conjugated equine estrogens on oxidative metabolism in middle-aged and elderly postmenopausal women. J Clin Pharmacol. 2006 Nov;46(11):1299-307. DMLT0E1 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=17050794 DMLT0E1 DI DMLT0E1 DMLT0E1 DN Conjugated estrogens DMLT0E1 MI DE4LYSA DMLT0E1 MN Cytochrome P450 3A4 (CYP3A4) DMLT0E1 MT DME DMLT0E1 MA Metabolism DMLT0E1 RN Conjugated oestrogens/bazedoxifene. Aust Prescr. 2017 Jun;40(3):114-115. DMLT0E1 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=28798519 DMLT0E1 DI DMLT0E1 DMLT0E1 DN Conjugated estrogens DMLT0E1 MI TTOM3J0 DMLT0E1 MN Estrogen receptor beta (ESR2) DMLT0E1 MT DTT DMLT0E1 MA Antagonist DMLT0E1 RN Differential biochemical and cellular actions of Premarin estrogens: distinct pharmacology of bazedoxifene-conjugated estrogens combination. Mol Endocrinol. 2009 Jan;23(1):74-85. DMLT0E1 RU https://pubmed.ncbi.nlm.nih.gov/19036900 DMTPIZC DI DMTPIZC DMTPIZC DN Conjugated estrogens a DMTPIZC MI TTZAYWL DMTPIZC MN Estrogen receptor (ESR) DMTPIZC MT DTT DMTPIZC MA Modulator DMTPIZC RN Natural products as sources of new drugs over the last 25 years. J Nat Prod. 2007 Mar;70(3):461-77. DMTPIZC RU https://pubmed.ncbi.nlm.nih.gov/17309302 DMU7SF8 DI DMU7SF8 DMU7SF8 DN Conjugated estrogens b DMU7SF8 MI TTZAYWL DMU7SF8 MN Estrogen receptor (ESR) DMU7SF8 MT DTT DMU7SF8 MA Modulator DMU7SF8 RN Effect of MK-486 alone on Parkinsonism; studies on the clinical symptoms and catecholamine concentrations in the blood, urine and cerebrospinal fluid. No To Shinkei. 1977 Feb;29(2):205-13. DMU7SF8 RU https://pubmed.ncbi.nlm.nih.gov/326277 DMF29Q5 DI DMF29Q5 DMF29Q5 DN Connexyn DMF29Q5 MI TTWG9A4 DMF29Q5 MN Adrenergic receptor alpha-2A (ADRA2A) DMF29Q5 MT DTT DMF29Q5 MA Agonist DMF29Q5 RN alpha2A-adrenergic receptors heterosynaptically regulate glutamatergic transmission in the bed nucleus of the stria terminalis. Neuroscience. 2009 Sep 29;163(1):339-51. DMF29Q5 RU https://pubmed.ncbi.nlm.nih.gov/19527774 DMF29Q5 DI DMF29Q5 DMF29Q5 DN Connexyn DMF29Q5 MI DE4LYSA DMF29Q5 MN Cytochrome P450 3A4 (CYP3A4) DMF29Q5 MT DME DMF29Q5 MA Metabolism DMF29Q5 RN Microsomal catalyzed N-hydroxylation of guanfacine and reduction of N-hydroxyguanfacine. Arch Pharm (Weinheim). 1997 Oct;330(9-10):303-6. DMF29Q5 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=9396389 DM26KR1 DI DM26KR1 DM26KR1 DN Copper dotatate Cu-64 DM26KR1 MI TTZ6T9E DM26KR1 MN Somatostatin receptor type 2 (SSTR2) DM26KR1 MT DTT DM26KR1 MA Binder DM26KR1 RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health Human Services. 2020 DM26KR1 RU https://www.accessdata.fda.gov/drugsatfda_docs/label/2020/213227s000lbl.pdf DMP9TWZ DI DMP9TWZ DMP9TWZ DN Corticotropin DMP9TWZ MI DE4LYSA DMP9TWZ MN Cytochrome P450 3A4 (CYP3A4) DMP9TWZ MT DME DMP9TWZ MA Metabolism DMP9TWZ RN Troglitazone induces CYP3A4 activity leading to falsely abnormal dexamethasone suppression test. J Clin Endocrinol Metab. 2003 Jul;88(7):3113-6. DMP9TWZ RU https://www.ncbi.nlm.nih.gov/pubmed/?term=12843151 DMU5QZX DI DMU5QZX DMU5QZX DN Cortisone DMU5QZX MI DTUGYRD DMU5QZX MN P-glycoprotein 1 (ABCB1) DMU5QZX MT DTP DMU5QZX MA Substrate DMU5QZX RN Structural determinants of P-glycoprotein-mediated transport of glucocorticoids. Pharm Res. 2003 Nov;20(11):1794-803. DMU5QZX RU http://www.ncbi.nlm.nih.gov/pubmed/14661924 DMG8K57 DI DMG8K57 DMG8K57 DN Cortisone acetate DMG8K57 MI DEZDRQO DMG8K57 MN Corticosteroid 11-beta-dehydrogenase 1 (HSD11B1) DMG8K57 MT DME DMG8K57 MA Metabolism DMG8K57 RN Comparative enzymology of 11beta-hydroxysteroid dehydrogenase type 1 from six species. J Mol Endocrinol. 2005 Aug;35(1):89-101. DMG8K57 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=16087724 DMG8K57 DI DMG8K57 DMG8K57 DN Cortisone acetate DMG8K57 MI DEDH7FP DMG8K57 MN Corticosteroid 11-beta-dehydrogenase 2 (HSD11B2) DMG8K57 MT DME DMG8K57 MA Metabolism DMG8K57 RN Comparative enzymology of 11beta-hydroxysteroid dehydrogenase type 1 from six species. J Mol Endocrinol. 2005 Aug;35(1):89-101. DMG8K57 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=16087724 DMG8K57 DI DMG8K57 DMG8K57 DN Cortisone acetate DMG8K57 MI DE4LYSA DMG8K57 MN Cytochrome P450 3A4 (CYP3A4) DMG8K57 MT DME DMG8K57 MA Metabolism DMG8K57 RN Prediction of tacrolimus metabolism and dosage requirements based on CYP3A4 phenotype and CYP3A5(*)3 genotype in Chinese renal transplant recipients. Acta Pharmacol Sin. 2016 Apr;37(4):555-60. DMG8K57 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=26924289 DMG8K57 DI DMG8K57 DMG8K57 DN Cortisone acetate DMG8K57 MI DEIBDNY DMG8K57 MN Cytochrome P450 3A5 (CYP3A5) DMG8K57 MT DME DMG8K57 MA Metabolism DMG8K57 RN Comparative pharmacokinetics and metabolism studies in lean and diet- induced obese mice: an animal efficacy model for 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1) inhibitors. Drug Metab Lett. 2011 Jan;5(1):55-63. DMG8K57 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=21198436 DMG8K57 DI DMG8K57 DMG8K57 DN Cortisone acetate DMG8K57 MI DERD86B DMG8K57 MN Cytochrome P450 3A7 (CYP3A7) DMG8K57 MT DME DMG8K57 MA Metabolism DMG8K57 RN Comparative pharmacokinetics and metabolism studies in lean and diet- induced obese mice: an animal efficacy model for 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1) inhibitors. Drug Metab Lett. 2011 Jan;5(1):55-63. DMG8K57 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=21198436 DMG8K57 DI DMG8K57 DMG8K57 DN Cortisone acetate DMG8K57 MI DEEXSKI DMG8K57 MN Short-chain dehydrogenase/reductase retSDR4 (DHRS7) DMG8K57 MT DME DMG8K57 MA Metabolism DMG8K57 RN Human DHRS7, promising enzyme in metabolism of steroids and retinoids? J Steroid Biochem Mol Biol. 2016 Jan;155(Pt A):112-9. DMG8K57 RU https://pubmed.ncbi.nlm.nih.gov/26466768 DMG8K57 DI DMG8K57 DMG8K57 DN Cortisone acetate DMG8K57 MI TTP3UTW DMG8K57 MN Steroid hormone receptor ERR (ESRR) DMG8K57 MT DTT DMG8K57 MA Modulator DMG8K57 RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. DMG8K57 RU https://www.fda.gov/ DMUIASK DI DMUIASK DMUIASK DN Cosyntropin DMUIASK MI TTPWFDX DMUIASK MN Melanocortin receptor 2 (MC2R) DMUIASK MT DTT DMUIASK MA Antagonist DMUIASK RN Hypothalamic-pituitary-adrenal axis dysfunction in hospitalized neonatal foals. J Vet Intern Med. 2009 Jul-Aug;23(4):901-12. DMUIASK RU https://pubmed.ncbi.nlm.nih.gov/19496914 DMCEZ1B DI DMCEZ1B DMCEZ1B DN Cotinine DMCEZ1B MI TTJSZTB DMCEZ1B MN Nicotinic acetylcholine receptor (nAChR) DMCEZ1B MT DTT DMCEZ1B MA Modulator DMCEZ1B RN Functional versus chemical diversity: is biodiversity important for drug discovery. Trends Pharmacol Sci. 2002 May;23(5):225-31. DMCEZ1B RU https://pubmed.ncbi.nlm.nih.gov/12008000 DMCEZ1B DI DMCEZ1B DMCEZ1B DN Cotinine DMCEZ1B MI DEI8NGH DMCEZ1B MN UDP-glucuronosyltransferase 2B10 (UGT2B10) DMCEZ1B MT DME DMCEZ1B MA Metabolism DMCEZ1B RN Human UDP-glucuronosyltransferase (UGT) 2B10: validation of cotinine as a selective probe substrate, inhibition by UGT enzyme-selective inhibitors and antidepressant and antipsychotic drugs, and structural determinants of enzyme inhibition. Drug Metab Dispos. 2016 Mar;44(3):378-88. DMCEZ1B RU https://www.ncbi.nlm.nih.gov/pubmed/?term=26669329 DMJ7IQX DI DMJ7IQX DMJ7IQX DN Crestor/TriLipix DMJ7IQX MI TTPADOQ DMJ7IQX MN HMG-CoA reductase (HMGCR) DMJ7IQX MT DTT DMJ7IQX MA Inhibitor DMJ7IQX RN Clinical pipeline report, company report or official report of AstraZeneca (2009). DMJ7IQX RU http://www.astrazeneca.com/_mshost3690701/content/resources/media/investors/AZN-Q2-2009/AZN-Q2-2009-Pipeline.pdf DMNVKU6 DI DMNVKU6 DMNVKU6 DN Crisaborole DMNVKU6 MI TTV5CGO DMNVKU6 MN Phosphodiesterase 4 (PDE4) DMNVKU6 MT DTT DMNVKU6 MA Modulator DMNVKU6 RN 2016 FDA drug approvals. Nat Rev Drug Discov. 2017 Feb 2;16(2):73-76. DMNVKU6 RU https://www.ncbi.nlm.nih.gov/pubmed/28148938 DMAHOVJ DI DMAHOVJ DMAHOVJ DN Crizanlizumab DMAHOVJ MI TTE5VG0 DMAHOVJ MN P-selectin (SELP) DMAHOVJ MT DTT DMAHOVJ MA Inhibitor DMAHOVJ RN Crizanlizumab: First Approval. Drugs. 2020 Jan;80(1):79-84. DMAHOVJ RU https://pubmed.ncbi.nlm.nih.gov/31933169 DM4F29C DI DM4F29C DM4F29C DN Crizotinib DM4F29C MI TTPMQSO DM4F29C MN ALK tyrosine kinase receptor (ALK) DM4F29C MT DTT DM4F29C MA Modulator DM4F29C RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015 DM4F29C RU https://www.accessdata.fda.gov/scripts/cder/drugsatfda/ DM4F29C DI DM4F29C DM4F29C DN Crizotinib DM4F29C MI DE4LYSA DM4F29C MN Cytochrome P450 3A4 (CYP3A4) DM4F29C MT DME DM4F29C MA Metabolism DM4F29C RN Crizotinib for the treatment of non-small-cell lung cancer. Am J Health Syst Pharm. 2013 Jun 1;70(11):943-7. DM4F29C RU https://www.ncbi.nlm.nih.gov/pubmed/?term=23686600 DM4F29C DI DM4F29C DM4F29C DN Crizotinib DM4F29C MI DEIBDNY DM4F29C MN Cytochrome P450 3A5 (CYP3A5) DM4F29C MT DME DM4F29C MA Metabolism DM4F29C RN Crizotinib for the treatment of non-small-cell lung cancer. Am J Health Syst Pharm. 2013 Jun 1;70(11):943-7. DM4F29C RU https://www.ncbi.nlm.nih.gov/pubmed/?term=23686600 DM4F29C DI DM4F29C DM4F29C DN Crizotinib DM4F29C MI TTKA5LP DM4F29C MN HGF/Met signaling pathway (HGF/Met pathway) DM4F29C MT DTT DM4F29C MA Inhibitor DM4F29C RN Met tyrosine kinase inhibitor, PF-2341066, suppresses growth and invasion of nasopharyngeal carcinoma.Drug Des Devel Ther. 2015 Aug 26;9:4897-907. DM4F29C RU https://pubmed.ncbi.nlm.nih.gov/26345996 DM4F29C DI DM4F29C DM4F29C DN Crizotinib DM4F29C MI DT3D8F0 DM4F29C MN Organic anion transporting polypeptide 1B1 (SLCO1B1) DM4F29C MT DTP DM4F29C MA Substrate DM4F29C RN Contribution of OATP1B1 and OATP1B3 to the disposition of sorafenib and sorafenib-glucuronide. Clin Cancer Res. 2013 Mar 15;19(6):1458-66. DM4F29C RU http://www.ncbi.nlm.nih.gov/pubmed/23340295 DM4F29C DI DM4F29C DM4F29C DN Crizotinib DM4F29C MI DT9C1TS DM4F29C MN Organic anion transporting polypeptide 1B3 (SLCO1B3) DM4F29C MT DTP DM4F29C MA Substrate DM4F29C RN Contribution of OATP1B1 and OATP1B3 to the disposition of sorafenib and sorafenib-glucuronide. Clin Cancer Res. 2013 Mar 15;19(6):1458-66. DM4F29C RU http://www.ncbi.nlm.nih.gov/pubmed/23340295 DM4F29C DI DM4F29C DM4F29C DN Crizotinib DM4F29C MI DTUGYRD DM4F29C MN P-glycoprotein 1 (ABCB1) DM4F29C MT DTP DM4F29C MA Substrate DM4F29C RN Increased oral availability and brain accumulation of the ALK inhibitor crizotinib by coadministration of the P-glycoprotein (ABCB1) and breast cancer resistance protein (ABCG2) inhibitor elacridar. Int J Cancer. 2014 Mar 15;134(6):1484-94. DM4F29C RU http://www.ncbi.nlm.nih.gov/pubmed/24037730 DM4F29C DI DM4F29C DM4F29C DN Crizotinib DM4F29C MI TTNDSF4 DM4F29C MN Proto-oncogene c-Met (MET) DM4F29C MT DTT DM4F29C MA Modulator DM4F29C RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015 DM4F29C RU https://www.accessdata.fda.gov/scripts/cder/drugsatfda/ DM4F29C DI DM4F29C DM4F29C DN Crizotinib DM4F29C MI TTSZ6Y3 DM4F29C MN Proto-oncogene c-Ros (ROS1) DM4F29C MT DTT DM4F29C MA Modulator DM4F29C RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015 DM4F29C RU https://www.accessdata.fda.gov/scripts/cder/drugsatfda/ DM4AMQZ DI DM4AMQZ DM4AMQZ DN Crofelemer DM4AMQZ MI TTOJI4S DM4AMQZ MN Calcium-dependent chloride channel anoctamin (ANO) DM4AMQZ MT DTT DM4AMQZ MA Modulator DM4AMQZ RN Nat Rev Drug Discov. 2013 Feb;12(2):87-90. DM4AMQZ RU https://pubmed.ncbi.nlm.nih.gov/23370234 DM4AMQZ DI DM4AMQZ DM4AMQZ DN Crofelemer DM4AMQZ MI TTRLZHP DM4AMQZ MN cAMP-dependent chloride channel (CFTR) DM4AMQZ MT DTT DM4AMQZ MA Modulator DM4AMQZ RN Nat Rev Drug Discov. 2013 Feb;12(2):87-90. DM4AMQZ RU https://pubmed.ncbi.nlm.nih.gov/23370234 DM74LZK DI DM74LZK DM74LZK DN Cromoglicate DM74LZK MI TT78R5H DM74LZK MN Heat shock protein 90 alpha (HSP90A) DM74LZK MT DTT DM74LZK MA Inhibitor DM74LZK RN Hsp90 is a direct target of the anti-allergic drugs disodium cromoglycate and amlexanox. Biochem J. 2003 Sep 1;374(Pt 2):433-41. DM74LZK RU https://pubmed.ncbi.nlm.nih.gov/12803546 DMHCTAL DI DMHCTAL DMHCTAL DN Cryptenamine Acetates DMHCTAL MI TTH18TF DMHCTAL MN Muscarinic acetylcholine receptor M5 (CHRM5) DMHCTAL MT DTT DMHCTAL MA Modulator DMHCTAL RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. DMHCTAL RU https://www.fda.gov/ DMB8PF3 DI DMB8PF3 DMB8PF3 DN CT-102 DMB8PF3 MI TTI2WET DMB8PF3 MN Platelet-derived growth factor receptor (PDGFR) DMB8PF3 MT DTT DMB8PF3 MA Activator DMB8PF3 RN Emerging drugs for diabetic foot ulcers. Expert Opin Emerg Drugs. 2006 Nov;11(4):709-24. DMB8PF3 RU https://pubmed.ncbi.nlm.nih.gov/17064227 DMP0NFQ DI DMP0NFQ DMP0NFQ DN Cupric Sulfate DMP0NFQ MI DTP8L4F DMP0NFQ MN High affinity copper uptake protein 1 (SLC31A1) DMP0NFQ MT DTP DMP0NFQ MA Substrate DMP0NFQ RN Role of the copper transporter, CTR1, in platinum-induced ototoxicity. J Neurosci. 2010 Jul 14;30(28):9500-9. DMP0NFQ RU http://www.ncbi.nlm.nih.gov/pubmed/20631178 DMHSJB4 DI DMHSJB4 DMHSJB4 DN Cyclacillin DMHSJB4 MI TTJP4SM DMHSJB4 MN Bacterial Penicillin binding protein (Bact PBP) DMHSJB4 MT DTT DMHSJB4 MA Binder DMHSJB4 RN Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. DMHSJB4 RU https://pubmed.ncbi.nlm.nih.gov/17016423 DMHSJB4 DI DMHSJB4 DMHSJB4 DN Cyclacillin DMHSJB4 MI DT9G7XN DMHSJB4 MN Peptide transporter 1 (SLC15A1) DMHSJB4 MT DTP DMHSJB4 MA Substrate DMHSJB4 RN Transport characteristics of a novel peptide transporter 1 substrate, antihypotensive drug midodrine, and its amino acid derivatives. J Pharmacol Exp Ther. 2006 Jul;318(1):455-60. DMHSJB4 RU http://www.ncbi.nlm.nih.gov/pubmed/16597710 DMHSJB4 DI DMHSJB4 DMHSJB4 DN Cyclacillin DMHSJB4 MI DT8QKNP DMHSJB4 MN Peptide transporter 2 (SLC15A2) DMHSJB4 MT DTP DMHSJB4 MA Substrate DMHSJB4 RN Transport characteristics of a novel peptide transporter 1 substrate, antihypotensive drug midodrine, and its amino acid derivatives. J Pharmacol Exp Ther. 2006 Jul;318(1):455-60. DMHSJB4 RU http://www.ncbi.nlm.nih.gov/pubmed/16597710 DMO0R76 DI DMO0R76 DMO0R76 DN Cyclandelate DMO0R76 MI DE4LYSA DMO0R76 MN Cytochrome P450 3A4 (CYP3A4) DMO0R76 MT DME DMO0R76 MA Metabolism DMO0R76 RN Integrated analysis on the physicochemical properties of dihydropyridine calcium channel blockers in grapefruit juice interactions. Curr Pharm Biotechnol. 2012 Jul;13(9):1705-17. DMO0R76 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=22039822 DM9G7BS DI DM9G7BS DM9G7BS DN Cyclizine DM9G7BS MI TTTIBOJ DM9G7BS MN Histamine H1 receptor (H1R) DM9G7BS MT DTT DM9G7BS MA Antagonist DM9G7BS RN Histamine H1-receptor antagonists, promethazine and homochlorcyclizine, increase the steady-state plasma concentrations of haloperidol and reduced haloperidol. Ther Drug Monit. 2003 Apr;25(2):192-6. DM9G7BS RU https://pubmed.ncbi.nlm.nih.gov/12657913 DM1YBRM DI DM1YBRM DM1YBRM DN Cyclobenzaprine DM1YBRM MI TTYSN63 DM1YBRM MN 5-HT 2 receptor (5HT2R) DM1YBRM MT DTT DM1YBRM MA Antagonist DM1YBRM RN Torticollis under Cyclobenzaprine. Pharmacology. 2009 Jul 8;84(2):91-92. DM1YBRM RU https://pubmed.ncbi.nlm.nih.gov/19590258 DM1YBRM DI DM1YBRM DM1YBRM DN Cyclobenzaprine DM1YBRM MI DEJGDUW DM1YBRM MN Cytochrome P450 1A2 (CYP1A2) DM1YBRM MT DME DM1YBRM MA Metabolism DM1YBRM RN Identification of human liver cytochrome P450 isoforms involved in the in vitro metabolism of cyclobenzaprine. Drug Metab Dispos. 1996 Jul;24(7):786-91. DM1YBRM RU https://www.ncbi.nlm.nih.gov/pubmed/?term=8818577 DM1YBRM DI DM1YBRM DM1YBRM DN Cyclobenzaprine DM1YBRM MI DECB0K3 DM1YBRM MN Cytochrome P450 2D6 (CYP2D6) DM1YBRM MT DME DM1YBRM MA Metabolism DM1YBRM RN Identification of human liver cytochrome P450 isoforms involved in the in vitro metabolism of cyclobenzaprine. Drug Metab Dispos. 1996 Jul;24(7):786-91. DM1YBRM RU https://www.ncbi.nlm.nih.gov/pubmed/?term=8818577 DM1YBRM DI DM1YBRM DM1YBRM DN Cyclobenzaprine DM1YBRM MI DE4LYSA DM1YBRM MN Cytochrome P450 3A4 (CYP3A4) DM1YBRM MT DME DM1YBRM MA Metabolism DM1YBRM RN Identification of human liver cytochrome P450 isoforms involved in the in vitro metabolism of cyclobenzaprine. Drug Metab Dispos. 1996 Jul;24(7):786-91. DM1YBRM RU https://www.ncbi.nlm.nih.gov/pubmed/?term=8818577 DMT5RMB DI DMT5RMB DMT5RMB DN Cyclofenil DMT5RMB MI TTZAYWL DMT5RMB MN Estrogen receptor (ESR) DMT5RMB MT DTT DMT5RMB MA Modulator DMT5RMB RN Fluorine-substituted cyclofenil derivatives as estrogen receptor ligands: synthesis and structure-affinity relationship study of potential positron emission tomography agents for imaging estrogen receptors in breast cancer. J Med Chem. 2006 Apr 20;49(8):2496-511. DMT5RMB RU https://pubmed.ncbi.nlm.nih.gov/16610793 DMA8LM5 DI DMA8LM5 DMA8LM5 DN Cyclopentolate DMA8LM5 MI TTH18TF DMA8LM5 MN Muscarinic acetylcholine receptor M5 (CHRM5) DMA8LM5 MT DTT DMA8LM5 MA Antagonist DMA8LM5 RN High spatial resolution studies of muscarinic neuroeffector junctions in mouse isolated vas deferens. Neuroscience. 2009 Sep 15;162(4):1366-76. DMA8LM5 RU https://pubmed.ncbi.nlm.nih.gov/19486927 DM4O2Z7 DI DM4O2Z7 DM4O2Z7 DN Cyclophosphamide DM4O2Z7 MI DEJVYAZ DM4O2Z7 MN Cytochrome P450 2A6 (CYP2A6) DM4O2Z7 MT DME DM4O2Z7 MA Metabolism DM4O2Z7 RN Development of a substrate-activity based approach to identify the major human liver P-450 catalysts of cyclophosphamide and ifosfamide activation based on cDNA-expressed activities and liver microsomal P-450 profiles. Drug Metab Dispos. 1999 Jun;27(6):655-66. DM4O2Z7 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=10348794 DM4O2Z7 DI DM4O2Z7 DM4O2Z7 DN Cyclophosphamide DM4O2Z7 MI DEPKLMQ DM4O2Z7 MN Cytochrome P450 2B6 (CYP2B6) DM4O2Z7 MT DME DM4O2Z7 MA Metabolism DM4O2Z7 RN The effect of cyclophosphamide with and without dexamethasone on cytochrome P450 3A4 and 2B6 in human hepatocytes. Drug Metab Dispos. 2002 Jul;30(7):814-22. DM4O2Z7 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=12065440 DM4O2Z7 DI DM4O2Z7 DM4O2Z7 DN Cyclophosphamide DM4O2Z7 MI DEZMWRE DM4O2Z7 MN Cytochrome P450 2C18 (CYP2C18) DM4O2Z7 MT DME DM4O2Z7 MA Metabolism DM4O2Z7 RN Development of a substrate-activity based approach to identify the major human liver P-450 catalysts of cyclophosphamide and ifosfamide activation based on cDNA-expressed activities and liver microsomal P-450 profiles. Drug Metab Dispos. 1999 Jun;27(6):655-66. DM4O2Z7 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=10348794 DM4O2Z7 DI DM4O2Z7 DM4O2Z7 DN Cyclophosphamide DM4O2Z7 MI DES5XRU DM4O2Z7 MN Cytochrome P450 2C8 (CYP2C8) DM4O2Z7 MT DME DM4O2Z7 MA Metabolism DM4O2Z7 RN Enhanced cyclophosphamide and ifosfamide activation in primary human hepatocyte cultures: response to cytochrome P-450 inducers and autoinduction by oxazaphosphorines. Cancer Res. 1997 May 15;57(10):1946-54. DM4O2Z7 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=9157990 DM4O2Z7 DI DM4O2Z7 DM4O2Z7 DN Cyclophosphamide DM4O2Z7 MI DE5IED8 DM4O2Z7 MN Cytochrome P450 2C9 (CYP2C9) DM4O2Z7 MT DME DM4O2Z7 MA Metabolism DM4O2Z7 RN CYP2C9 polymorphisms in human tumors. Anticancer Res. 2006 Jan-Feb;26(1A):299-305. DM4O2Z7 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=16475710 DM4O2Z7 DI DM4O2Z7 DM4O2Z7 DN Cyclophosphamide DM4O2Z7 MI DE4LYSA DM4O2Z7 MN Cytochrome P450 3A4 (CYP3A4) DM4O2Z7 MT DME DM4O2Z7 MA Metabolism DM4O2Z7 RN Effects of ketoconazole on cyclophosphamide metabolism: evaluation of CYP3A4 inhibition effect using the in vitro and in vivo models. Exp Anim. 2018 Feb 9;67(1):71-82. DM4O2Z7 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=29129847 DM4O2Z7 DI DM4O2Z7 DM4O2Z7 DN Cyclophosphamide DM4O2Z7 MI DERD86B DM4O2Z7 MN Cytochrome P450 3A7 (CYP3A7) DM4O2Z7 MT DME DM4O2Z7 MA Metabolism DM4O2Z7 RN Summary of information on human CYP enzymes: human P450 metabolism data. Drug Metab Rev. 2002 Feb-May;34(1-2):83-448. DM4O2Z7 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=11996015 DM4O2Z7 DI DM4O2Z7 DM4O2Z7 DN Cyclophosphamide DM4O2Z7 MI TTUTN1I DM4O2Z7 MN Human Deoxyribonucleic acid (hDNA) DM4O2Z7 MT DTT DM4O2Z7 MA Modulator DM4O2Z7 RN O6-methylguanine-DNA methyltransferase activity and sensitivity to cyclophosphamide and cisplatin in human lung tumor xenografts. Int J Cancer. 1998 Sep 11;77(6):919-22. DM4O2Z7 RU https://www.ncbi.nlm.nih.gov/pubmed/9714064 DM4O2Z7 DI DM4O2Z7 DM4O2Z7 DN Cyclophosphamide DM4O2Z7 MI DEGTFWK DM4O2Z7 MN Mephenytoin 4-hydroxylase (CYP2C19) DM4O2Z7 MT DME DM4O2Z7 MA Metabolism DM4O2Z7 RN Cytochrome P450 pharmacogenetics and cancer. Oncogene. 2006 Mar 13;25(11):1679-91. DM4O2Z7 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=16550168 DM4O2Z7 DI DM4O2Z7 DM4O2Z7 DN Cyclophosphamide DM4O2Z7 MI DTCSGPB DM4O2Z7 MN Multidrug resistance-associated protein 4 (ABCC4) DM4O2Z7 MT DTP DM4O2Z7 MA Substrate DM4O2Z7 RN Interaction of oxazaphosphorines with multidrug resistance-associated protein 4 (MRP4). AAPS J. 2010 Sep;12(3):300-8. DM4O2Z7 RU http://www.ncbi.nlm.nih.gov/pubmed/20405259 DMT1I52 DI DMT1I52 DMT1I52 DN Cycloserine DMT1I52 MI TTLD29N DMT1I52 MN Glutamate receptor ionotropic NMDA 1 (NMDAR1) DMT1I52 MT DTT DMT1I52 MA Inhibitor DMT1I52 RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMT1I52 RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMT1I52 DI DMT1I52 DMT1I52 DN Cycloserine DMT1I52 MI TT6TMZU DMT1I52 MN Mycobacterium Biosynthetic alanine racemase (MycB alr) DMT1I52 MT DTT DMT1I52 MA Inhibitor DMT1I52 RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMT1I52 RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMT1I52 DI DMT1I52 DMT1I52 DN Cycloserine DMT1I52 MI TTCS3P1 DMT1I52 MN Mycobacterium D-alanine-D-alanine ligase A (MycB ddl) DMT1I52 MT DTT DMT1I52 MA Inhibitor DMT1I52 RN Self-protection mechanism in D-cycloserine-producing Streptomyces lavendulae. Gene cloning, characterization, and kinetics of its alanine racemase ... J Biol Chem. 2004 Oct 29;279(44):46143-52. DMT1I52 RU https://pubmed.ncbi.nlm.nih.gov/15302885 DMT1I52 DI DMT1I52 DMT1I52 DN Cycloserine DMT1I52 MI TT9IK2Z DMT1I52 MN N-methyl-D-aspartate receptor (NMDAR) DMT1I52 MT DTT DMT1I52 MA Agonist DMT1I52 RN How many modes of action should an antibiotic have Curr Opin Pharmacol. 2008 Oct;8(5):564-73. DMT1I52 RU https://pubmed.ncbi.nlm.nih.gov/18621146 DMT1I52 DI DMT1I52 DMT1I52 DN Cycloserine DMT1I52 MI DT48WEM DMT1I52 MN Proton-coupled amino acid transporter 1 (SLC36A1) DMT1I52 MT DTP DMT1I52 MA Substrate DMT1I52 RN Indirect regulation of the intestinal H+-coupled amino acid transporter hPAT1 (SLC36A1). J Cell Physiol. 2005 Aug;204(2):604-13. DMT1I52 RU http://www.ncbi.nlm.nih.gov/pubmed/15754324 DMT1I52 DI DMT1I52 DMT1I52 DN Cycloserine DMT1I52 MI DTAOPTV DMT1I52 MN Proton-coupled amino acid transporter 2 (SLC36A2) DMT1I52 MT DTP DMT1I52 MA Substrate DMT1I52 RN Substrate specificity and functional characterisation of the H+/amino acid transporter rat PAT2 (Slc36a2). Br J Pharmacol. 2005 Jan;144(1):28-41. DMT1I52 RU http://www.ncbi.nlm.nih.gov/pubmed/15644866 DMJ4AWC DI DMJ4AWC DMJ4AWC DN Cyclothiazide DMJ4AWC MI TTANPDJ DMJ4AWC MN Carbonic anhydrase II (CA-II) DMJ4AWC MT DTT DMJ4AWC MA Inhibitor DMJ4AWC RN Selective effect of thiazides on the human osteoblast-like cell line MG-63. Kidney Int. 1996 Nov;50(5):1476-82. DMJ4AWC RU https://pubmed.ncbi.nlm.nih.gov/8914012 DM8C43Q DI DM8C43Q DM8C43Q DN Cycrimine DM8C43Q MI TTZ9SOR DM8C43Q MN Muscarinic acetylcholine receptor M1 (CHRM1) DM8C43Q MT DTT DM8C43Q MA Binder DM8C43Q RN Capillary gas chromatography of trihexyphenidyl, procyclidine and cycrimine in biological fluids. J Chromatogr. 1989 Sep 29;494:135-42. DM8C43Q RU https://pubmed.ncbi.nlm.nih.gov/2573609 DMUY2OR DI DMUY2OR DMUY2OR DN Cynarin DMUY2OR MI TTLOQ79 DMUY2OR MN Taste receptor (TASR) DMUY2OR MT DTT DMUY2OR MA Modulator DMUY2OR RN Medicinal plants in therapy. Bull World Health Organ. 1985;63(6):965-81. DMUY2OR RU https://pubmed.ncbi.nlm.nih.gov/3879679 DM92AH3 DI DM92AH3 DM92AH3 DN Cyproheptadine DM92AH3 MI TTTIBOJ DM92AH3 MN Histamine H1 receptor (H1R) DM92AH3 MT DTT DM92AH3 MA Antagonist DM92AH3 RN Cyproheptadine displays preclinical activity in myeloma and leukemia. Blood. 2008 Aug 1;112(3):760-9. DM92AH3 RU https://pubmed.ncbi.nlm.nih.gov/18502826 DM92AH3 DI DM92AH3 DM92AH3 DN Cyproheptadine DM92AH3 MI DEYGVN4 DM92AH3 MN UDP-glucuronosyltransferase 1A1 (UGT1A1) DM92AH3 MT DME DM92AH3 MA Metabolism DM92AH3 RN Effect of common exon variant (p.P364L) on drug glucuronidation by the human UDP-glucuronosyltransferase 1 family. Basic Clin Pharmacol Toxicol. 2011 Dec;109(6):486-93. DM92AH3 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=21726413 DM92AH3 DI DM92AH3 DM92AH3 DN Cyproheptadine DM92AH3 MI DEF2WXN DM92AH3 MN UDP-glucuronosyltransferase 1A3 (UGT1A3) DM92AH3 MT DME DM92AH3 MA Metabolism DM92AH3 RN Glucuronidation of amines and other xenobiotics catalyzed by expressed human UDP-glucuronosyltransferase 1A3. Drug Metab Dispos. 1998 Jun;26(6):507-12. DM92AH3 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=9616184 DMQXLD2 DI DMQXLD2 DMQXLD2 DN Cyproterone DMQXLD2 MI TTS64P2 DMQXLD2 MN Androgen receptor (AR) DMQXLD2 MT DTT DMQXLD2 MA Antagonist DMQXLD2 RN Coactivator selective regulation of androgen receptor activity. Steroids. 2009 Aug;74(8):669-74. DMQXLD2 RU https://pubmed.ncbi.nlm.nih.gov/19463689 DMSYFM8 DI DMSYFM8 DMSYFM8 DN Cysteamine DMSYFM8 MI DEA3U9Y DMSYFM8 MN Myeloperoxidase (MPO) DMSYFM8 MT DME DMSYFM8 MA Metabolism DMSYFM8 RN Thiols as peroxidase substrates. Free Radic Biol Med. 1993 Feb;14(2):167-75. DMSYFM8 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=8381104 DMSYFM8 DI DMSYFM8 DMSYFM8 DN Cysteamine DMSYFM8 MI TTWF7UG DMSYFM8 MN Somatostatin (SST) DMSYFM8 MT DTT DMSYFM8 MA Binder DMSYFM8 RN Somatostatin, Alzheimer's disease and cognition: an old story coming of age Prog Neurobiol. 2009 Oct;89(2):153-61. DMSYFM8 RU https://pubmed.ncbi.nlm.nih.gov/19595735 DMZD5QR DI DMZD5QR DMZD5QR DN Cytarabine DMZD5QR MI DT0EQPW DMZD5QR MN Concentrative nucleoside transporter 1 (SLC28A1) DMZD5QR MT DTP DMZD5QR MA Substrate DMZD5QR RN FLT3 is implicated in cytarabine transport by human equilibrative nucleoside transporter 1 in pediatric acute leukemia. Oncotarget. 2016 Aug 2;7(31):49786-49799. DMZD5QR RU http://www.ncbi.nlm.nih.gov/pubmed/27391351 DMZD5QR DI DMZD5QR DMZD5QR DN Cytarabine DMZD5QR MI DEKEDRC DMZD5QR MN Cytidine aminohydrolase (CDA) DMZD5QR MT DME DMZD5QR MA Metabolism DMZD5QR RN Genetic factors influencing cytarabine therapy. Pharmacogenomics. 2009 Oct;10(10):1657-74. DMZD5QR RU https://www.ncbi.nlm.nih.gov/pubmed/?term=19842938 DMZD5QR DI DMZD5QR DMZD5QR DN Cytarabine DMZD5QR MI DEYILK4 DMZD5QR MN Cytidine deaminase (cdd) DMZD5QR MT DME DMZD5QR MA Metabolism DMZD5QR RN Mycoplasma hyorhinis-encoded cytidine deaminase efficiently inactivates cytosine-based anticancer drugs. FEBS Open Bio. 2015 Aug 3;5:634-9. DMZD5QR RU https://pubmed.ncbi.nlm.nih.gov/26322268 DMZD5QR DI DMZD5QR DMZD5QR DN Cytarabine DMZD5QR MI DE4LYSA DMZD5QR MN Cytochrome P450 3A4 (CYP3A4) DMZD5QR MT DME DMZD5QR MA Metabolism DMZD5QR RN Synthesis and characterization of a novel liver-targeted prodrug of cytosine-1-beta-D-arabinofuranoside monophosphate for the treatment of hepatocellular carcinoma. J Med Chem. 2006 Dec 28;49(26):7711-20. DMZD5QR RU https://www.ncbi.nlm.nih.gov/pubmed/?term=17181153 DMZD5QR DI DMZD5QR DMZD5QR DN Cytarabine DMZD5QR MI DEXL3P2 DMZD5QR MN Deoxycytidylate deaminase (DCTD) DMZD5QR MT DME DMZD5QR MA Metabolism DMZD5QR RN Genetic factors influencing cytarabine therapy. Pharmacogenomics. 2009 Oct;10(10):1657-74. DMZD5QR RU https://www.ncbi.nlm.nih.gov/pubmed/?term=19842938 DMZD5QR DI DMZD5QR DMZD5QR DN Cytarabine DMZD5QR MI DE3Z9HM DMZD5QR MN Ecto-5'-nucleotidase (NT5E) DMZD5QR MT DME DMZD5QR MA Metabolism DMZD5QR RN Genetic factors influencing cytarabine therapy. Pharmacogenomics. 2009 Oct;10(10):1657-74. DMZD5QR RU https://www.ncbi.nlm.nih.gov/pubmed/?term=19842938 DMZD5QR DI DMZD5QR DMZD5QR DN Cytarabine DMZD5QR MI DTXD1TQ DMZD5QR MN Equilibrative nucleoside transporter 1 (SLC29A1) DMZD5QR MT DTP DMZD5QR MA Substrate DMZD5QR RN FLT3 is implicated in cytarabine transport by human equilibrative nucleoside transporter 1 in pediatric acute leukemia. Oncotarget. 2016 Aug 2;7(31):49786-49799. DMZD5QR RU http://www.ncbi.nlm.nih.gov/pubmed/27391351 DMZD5QR DI DMZD5QR DMZD5QR DN Cytarabine DMZD5QR MI DTW78DQ DMZD5QR MN Equilibrative nucleoside transporter 2 (SLC29A2) DMZD5QR MT DTP DMZD5QR MA Substrate DMZD5QR RN FLT3 is implicated in cytarabine transport by human equilibrative nucleoside transporter 1 in pediatric acute leukemia. Oncotarget. 2016 Aug 2;7(31):49786-49799. DMZD5QR RU http://www.ncbi.nlm.nih.gov/pubmed/27391351 DMZD5QR DI DMZD5QR DMZD5QR DN Cytarabine DMZD5QR MI TTIU7X1 DMZD5QR MN Herpes simplex virus DNA polymerase UL30 (HSV UL30) DMZD5QR MT DTT DMZD5QR MA Inhibitor DMZD5QR RN Chromatin-associated proteins HMGB1/2 and PDIA3 trigger cellular response to chemotherapy-induced DNA damage. Mol Cancer Ther. 2009 Apr;8(4):864-72. DMZD5QR RU https://pubmed.ncbi.nlm.nih.gov/19372559 DMZD5QR DI DMZD5QR DMZD5QR DN Cytarabine DMZD5QR MI DTT79CX DMZD5QR MN Organic cation transporter 1 (SLC22A1) DMZD5QR MT DTP DMZD5QR MA Substrate DMZD5QR RN Human intestinal transporter database: QSAR modeling and virtual profiling of drug uptake, efflux and interactions. Pharm Res. 2013 Apr;30(4):996-1007. DMZD5QR RU https://doi.org/10.1007/s11095-012-0935-x DMZD5QR DI DMZD5QR DMZD5QR DN Cytarabine DMZD5QR MI DT2EG60 DMZD5QR MN Organic cation/carnitine transporter 1 (SLC22A4) DMZD5QR MT DTP DMZD5QR MA Substrate DMZD5QR RN OCTN1 Is a High-Affinity Carrier of Nucleoside Analogues. Cancer Res. 2017 Apr 15;77(8):2102-2111. DMZD5QR RU http://www.ncbi.nlm.nih.gov/pubmed/28209616 DMZD5QR DI DMZD5QR DMZD5QR DN Cytarabine DMZD5QR MI DTUGYRD DMZD5QR MN P-glycoprotein 1 (ABCB1) DMZD5QR MT DTP DMZD5QR MA Substrate DMZD5QR RN Mammalian drug efflux transporters of the ATP binding cassette (ABC) family in multidrug resistance: A review of the past decade. Cancer Lett. 2016 Jan 1;370(1):153-64. DMZD5QR RU http://www.ncbi.nlm.nih.gov/pubmed/26499806 DMDI6R4 DI DMDI6R4 DMDI6R4 DN Dabigatran DMDI6R4 MI TT6L509 DMDI6R4 MN Coagulation factor IIa (F2) DMDI6R4 MT DTT DMDI6R4 MA Inhibitor DMDI6R4 RN Mullard A: 2010 FDA drug approvals. Nat Rev Drug Discov. 2011 Feb;10(2):82-5. DMDI6R4 RU https://pubmed.ncbi.nlm.nih.gov/21283092 DMDI6R4 DI DMDI6R4 DMDI6R4 DN Dabigatran DMDI6R4 MI DTUGYRD DMDI6R4 MN P-glycoprotein 1 (ABCB1) DMDI6R4 MT DTP DMDI6R4 MA Substrate DMDI6R4 RN Influence of ABCB11 and HNF4 genes on daclatasvir plasma concentration: preliminary pharmacogenetic data from the Kineti-C study. J Antimicrob Chemother. 2017 Oct 1;72(10):2846-2849. DMDI6R4 RU http://www.ncbi.nlm.nih.gov/pubmed/29091211 DMX6OE3 DI DMX6OE3 DMX6OE3 DN Dabrafenib DMX6OE3 MI DTI7UX6 DMX6OE3 MN Breast cancer resistance protein (ABCG2) DMX6OE3 MT DTP DMX6OE3 MA Substrate DMX6OE3 RN Mechanisms limiting distribution of the threonine-protein kinase B-RaF(V600E) inhibitor dabrafenib to the brain: implications for the treatment of melanoma brain metastases. J Pharmacol Exp Ther. 2013 Mar;344(3):655-64. DMX6OE3 RU http://www.ncbi.nlm.nih.gov/pubmed/23249624 DMX6OE3 DI DMX6OE3 DMX6OE3 DN Dabrafenib DMX6OE3 MI DES5XRU DMX6OE3 MN Cytochrome P450 2C8 (CYP2C8) DMX6OE3 MT DME DMX6OE3 MA Metabolism DMX6OE3 RN Role of cytochrome P450 2C8 in drug metabolism and interactions. Pharmacol Rev. 2016 Jan;68(1):168-241. DMX6OE3 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=26721703 DMX6OE3 DI DMX6OE3 DMX6OE3 DN Dabrafenib DMX6OE3 MI DE4LYSA DMX6OE3 MN Cytochrome P450 3A4 (CYP3A4) DMX6OE3 MT DME DMX6OE3 MA Metabolism DMX6OE3 RN Physiologically based pharmacokinetic modeling to identify physiological and molecular characteristics driving variability in drug exposure. Clin Pharmacol Ther. 2018 Dec;104(6):1219-1228. DMX6OE3 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=29574693 DMX6OE3 DI DMX6OE3 DMX6OE3 DN Dabrafenib DMX6OE3 MI DTUGYRD DMX6OE3 MN P-glycoprotein 1 (ABCB1) DMX6OE3 MT DTP DMX6OE3 MA Substrate DMX6OE3 RN Mechanisms limiting distribution of the threonine-protein kinase B-RaF(V600E) inhibitor dabrafenib to the brain: implications for the treatment of melanoma brain metastases. J Pharmacol Exp Ther. 2013 Mar;344(3):655-64. DMX6OE3 RU http://www.ncbi.nlm.nih.gov/pubmed/23249624 DMX6OE3 DI DMX6OE3 DMX6OE3 DN Dabrafenib DMX6OE3 MI TTWCGQT DMX6OE3 MN Serine/threonine-protein kinase B-raf (BRAF) DMX6OE3 MT DTT DMX6OE3 MA Inhibitor DMX6OE3 RN Clinical pipeline report, company report or official report of GlaxoSmithKline (2011). DMX6OE3 RU http://www.gsk.com/ DMNPZL4 DI DMNPZL4 DMNPZL4 DN Dacarbazine DMNPZL4 MI DE6OQ3W DMNPZL4 MN Cytochrome P450 1A1 (CYP1A1) DMNPZL4 MT DME DMNPZL4 MA Metabolism DMNPZL4 RN Metabolic activation of dacarbazine by human cytochromes P450: the role of CYP1A1, CYP1A2, and CYP2E1. Clin Cancer Res. 1999 Aug;5(8):2192-7. DMNPZL4 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=10473105 DMNPZL4 DI DMNPZL4 DMNPZL4 DN Dacarbazine DMNPZL4 MI DEJGDUW DMNPZL4 MN Cytochrome P450 1A2 (CYP1A2) DMNPZL4 MT DME DMNPZL4 MA Metabolism DMNPZL4 RN Study on mesenchymal stem cells mediated enzyme-prodrug gene CYP1A2 targeting anti-tumor effect. Zhonghua Xue Ye Xue Za Zhi. 2009 Oct;30(10):667-71. DMNPZL4 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=19954661 DMNPZL4 DI DMNPZL4 DMNPZL4 DN Dacarbazine DMNPZL4 MI DEVDYN7 DMNPZL4 MN Cytochrome P450 2E1 (CYP2E1) DMNPZL4 MT DME DMNPZL4 MA Metabolism DMNPZL4 RN Role of cytochrome P450 isoenzymes in metabolism of O(6)-benzylguanine: implications for dacarbazine activation. Clin Cancer Res. 2001 Dec;7(12):4239-44. DMNPZL4 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=11751525 DMNPZL4 DI DMNPZL4 DMNPZL4 DN Dacarbazine DMNPZL4 MI TTUTN1I DMNPZL4 MN Human Deoxyribonucleic acid (hDNA) DMNPZL4 MT DTT DMNPZL4 MA Breaker DMNPZL4 RN Predicting the myelotoxicity of chemotherapy: the use of pretreatment O6-methylguanine-DNA methyltransferase determination in peripheral blood mono... Melanoma Res. 2011 Dec;21(6):502-8. DMNPZL4 RU https://pubmed.ncbi.nlm.nih.gov/19561552 DMSFK9V DI DMSFK9V DMSFK9V DN Daclatasvir DMSFK9V MI DE4LYSA DMSFK9V MN Cytochrome P450 3A4 (CYP3A4) DMSFK9V MT DME DMSFK9V MA Metabolism DMSFK9V RN Daclatasvir: a NS5A replication complex inhibitor for hepatitis C infection. Ann Pharmacother. 2016 Jan;50(1):39-46. DMSFK9V RU https://www.ncbi.nlm.nih.gov/pubmed/?term=26486762 DMSFK9V DI DMSFK9V DMSFK9V DN Daclatasvir DMSFK9V MI DEIBDNY DMSFK9V MN Cytochrome P450 3A5 (CYP3A5) DMSFK9V MT DME DMSFK9V MA Metabolism DMSFK9V RN Daclatasvir: a NS5A replication complex inhibitor for hepatitis C infection. Ann Pharmacother. 2016 Jan;50(1):39-46. DMSFK9V RU https://www.ncbi.nlm.nih.gov/pubmed/?term=26486762 DMSFK9V DI DMSFK9V DMSFK9V DN Daclatasvir DMSFK9V MI DERD86B DMSFK9V MN Cytochrome P450 3A7 (CYP3A7) DMSFK9V MT DME DMSFK9V MA Metabolism DMSFK9V RN Daclatasvir: a NS5A replication complex inhibitor for hepatitis C infection. Ann Pharmacother. 2016 Jan;50(1):39-46. DMSFK9V RU https://www.ncbi.nlm.nih.gov/pubmed/?term=26486762 DMSFK9V DI DMSFK9V DMSFK9V DN Daclatasvir DMSFK9V MI TTCJ2X8 DMSFK9V MN Hepatitis C virus Non-structural 5A (HCV NS5A) DMSFK9V MT DTT DMSFK9V MA Inhibitor DMSFK9V RN 2011 Pipeline of Bristol-Myers Squibb. DMSFK9V RU http://www.bms.com/pages/default.aspx DMSFK9V DI DMSFK9V DMSFK9V DN Daclatasvir DMSFK9V MI DTUGYRD DMSFK9V MN P-glycoprotein 1 (ABCB1) DMSFK9V MT DTP DMSFK9V MA Substrate DMSFK9V RN Influence of ABCB11 and HNF4 genes on daclatasvir plasma concentration: preliminary pharmacogenetic data from the Kineti-C study. J Antimicrob Chemother. 2017 Oct 1;72(10):2846-2849. DMSFK9V RU http://www.ncbi.nlm.nih.gov/pubmed/29091211 DM6OZQV DI DM6OZQV DM6OZQV DN Daclizumab DM6OZQV MI TTF89GD DM6OZQV MN Interleukin-2 (IL2) DM6OZQV MT DTT DM6OZQV MA Modulator DM6OZQV RN 2016 FDA drug approvals. Nat Rev Drug Discov. 2017 Feb 2;16(2):73-76. DM6OZQV RU https://www.ncbi.nlm.nih.gov/pubmed/28148938 DMOH8VY DI DMOH8VY DMOH8VY DN Dacomitinib DMOH8VY MI DE5IED8 DMOH8VY MN Cytochrome P450 2C9 (CYP2C9) DMOH8VY MT DME DMOH8VY MA Metabolism DMOH8VY RN Phase 1 study to investigate the pharmacokinetic properties of dacomitinib in healthy adult Chinese subjects genotyped for CYP2D6. Xenobiotica. 2018 May;48(5):459-466. DMOH8VY RU https://www.ncbi.nlm.nih.gov/pubmed/?term=28648122 DMOH8VY DI DMOH8VY DMOH8VY DN Dacomitinib DMOH8VY MI DECB0K3 DMOH8VY MN Cytochrome P450 2D6 (CYP2D6) DMOH8VY MT DME DMOH8VY MA Metabolism DMOH8VY RN Phase 1 study to investigate the pharmacokinetic properties of dacomitinib in healthy adult Chinese subjects genotyped for CYP2D6. Xenobiotica. 2018 May;48(5):459-466. DMOH8VY RU https://www.ncbi.nlm.nih.gov/pubmed/?term=28648122 DMOH8VY DI DMOH8VY DMOH8VY DN Dacomitinib DMOH8VY MI DE4LYSA DMOH8VY MN Cytochrome P450 3A4 (CYP3A4) DMOH8VY MT DME DMOH8VY MA Metabolism DMOH8VY RN Phase 1 study to investigate the pharmacokinetic properties of dacomitinib in healthy adult Chinese subjects genotyped for CYP2D6. Xenobiotica. 2018 May;48(5):459-466. DMOH8VY RU https://www.ncbi.nlm.nih.gov/pubmed/?term=28648122 DMOH8VY DI DMOH8VY DMOH8VY DN Dacomitinib DMOH8VY MI TTGKNB4 DMOH8VY MN Epidermal growth factor receptor (EGFR) DMOH8VY MT DTT DMOH8VY MA Antagonist DMOH8VY RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1797). DMOH8VY RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1797 DMOH8VY DI DMOH8VY DMOH8VY DN Dacomitinib DMOH8VY MI TT6EO5L DMOH8VY MN Erbb2 tyrosine kinase receptor (HER2) DMOH8VY MT DTT DMOH8VY MA Antagonist DMOH8VY RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7422). DMOH8VY RU http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=7422 DMOH8VY DI DMOH8VY DMOH8VY DN Dacomitinib DMOH8VY MI TT0JESD DMOH8VY MN Erbb4 tyrosine kinase receptor (Erbb-4) DMOH8VY MT DTT DMOH8VY MA Antagonist DMOH8VY RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7422). DMOH8VY RU http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=7422 DM2YGNW DI DM2YGNW DM2YGNW DN Dactinomycin DM2YGNW MI DTI7UX6 DM2YGNW MN Breast cancer resistance protein (ABCG2) DM2YGNW MT DTP DM2YGNW MA Substrate DM2YGNW RN Breast cancer resistance protein (BCRP/ABCG2) induces cellular resistance to HIV-1 nucleoside reverse transcriptase inhibitors. Mol Pharmacol. 2003 Jan;63(1):65-72. DM2YGNW RU https://doi.org/10.1124/mol.63.1.65 DM2YGNW DI DM2YGNW DM2YGNW DN Dactinomycin DM2YGNW MI TTUTN1I DM2YGNW MN Human Deoxyribonucleic acid (hDNA) DM2YGNW MT DTT DM2YGNW MA Breaker DM2YGNW RN Structural studies of atom-specific anticancer drugs acting on DNA. Pharmacol Ther. 1999 Sep;83(3):181-215. DM2YGNW RU https://pubmed.ncbi.nlm.nih.gov/10576292 DM2YGNW DI DM2YGNW DM2YGNW DN Dactinomycin DM2YGNW MI DTSYQGK DM2YGNW MN Multidrug resistance-associated protein 1 (ABCC1) DM2YGNW MT DTP DM2YGNW MA Substrate DM2YGNW RN Expression of multidrug resistance-associated protein in NIH/3T3 cells confers multidrug resistance associated with increased drug efflux and altered intracellular drug distribution. Cancer Res. 1995 Nov 15;55(22):5342-7. DM2YGNW RU http://cancerres.aacrjournals.org/content/55/22/5342 DM2YGNW DI DM2YGNW DM2YGNW DN Dactinomycin DM2YGNW MI DTUGYRD DM2YGNW MN P-glycoprotein 1 (ABCB1) DM2YGNW MT DTP DM2YGNW MA Substrate DM2YGNW RN Potential role of drug transporters in the pathogenesis of medically intractable epilepsy. Epilepsia. 2005 Feb;46(2):224-35. DM2YGNW RU https://doi.org/10.1111/j.0013-9580.2005.31904.x DMGMNH3 DI DMGMNH3 DMGMNH3 DN Dalbavancin DMGMNH3 MI TTXMY0J DMGMNH3 MN Pancreatic triacylglycerol lipase (PNLIP) DMGMNH3 MT DTT DMGMNH3 MA Inhibitor DMGMNH3 RN Pfizer. Product Development Pipeline. March 31 2009. DMGMNH3 RU http://media.pfizer.com/files/research/pipeline/2009_0331/pipeline_2009_0331.pdf DMM0PDO DI DMM0PDO DMM0PDO DN Dalfampridine DMM0PDO MI DEVDYN7 DMM0PDO MN Cytochrome P450 2E1 (CYP2E1) DMM0PDO MT DME DMM0PDO MA Metabolism DMM0PDO RN Dalfampridine: a medication to improve walking in patients with multiple sclerosis. Ann Pharmacother. 2012 Jul-Aug;46(7-8):1010-5. DMM0PDO RU https://www.ncbi.nlm.nih.gov/pubmed/?term=22764324 DMM0PDO DI DMM0PDO DMM0PDO DN Dalfampridine DMM0PDO MI TT1VOHK DMM0PDO MN Potassium channel unspecific (KC) DMM0PDO MT DTT DMM0PDO MA Modulator DMM0PDO RN Mullard A: 2010 FDA drug approvals. Nat Rev Drug Discov. 2011 Feb;10(2):82-5. DMM0PDO RU https://pubmed.ncbi.nlm.nih.gov/21283092 DM4LTKV DI DM4LTKV DM4LTKV DN Dalfopristin DM4LTKV MI TTUWYEA DM4LTKV MN Bacterial 50S ribosomal RNA (Bact 50S rRNA) DM4LTKV MT DTT DM4LTKV MA Binder DM4LTKV RN The streptogramin antibiotics: update on their mechanism of action. Expert Opin Investig Drugs. 1998 Apr;7(4):591-9. DM4LTKV RU https://pubmed.ncbi.nlm.nih.gov/15991995 DM6CLBN DI DM6CLBN DM6CLBN DN Danaparoid DM6CLBN MI TTCIHJA DM6CLBN MN Coagulation factor Xa (F10) DM6CLBN MT DTT DM6CLBN MA Inhibitor DM6CLBN RN Effect of factor X inhibition on coagulation activation and cytokine induction in human systemic inflammation. J Infect Dis. 2002 Nov 1;186(9):1270-6. DM6CLBN RU https://pubmed.ncbi.nlm.nih.gov/12402196 DML8KTN DI DML8KTN DML8KTN DN Danazol DML8KTN MI TTZAYWL DML8KTN MN Estrogen receptor (ESR) DML8KTN MT DTT DML8KTN MA Antagonist DML8KTN RN Danazol suppression of luteinizing hormone in the rat: evidence for mediation by both androgen and estrogen receptors. Proc Soc Exp Biol Med. 1990 May;194(1):54-7. DML8KTN RU https://pubmed.ncbi.nlm.nih.gov/2326286 DM1D8XY DI DM1D8XY DM1D8XY DN Dantrolene DM1D8XY MI DE4LYSA DM1D8XY MN Cytochrome P450 3A4 (CYP3A4) DM1D8XY MT DME DM1D8XY MA Metabolism DM1D8XY RN Summary of information on human CYP enzymes: human P450 metabolism data. Drug Metab Rev. 2002 Feb-May;34(1-2):83-448. DM1D8XY RU https://www.ncbi.nlm.nih.gov/pubmed/?term=11996015 DM1D8XY DI DM1D8XY DM1D8XY DN Dantrolene DM1D8XY MI TT9YXM1 DM1D8XY MN Ryanodine receptor (RYR) DM1D8XY MT DTT DM1D8XY MA Modulator DM1D8XY RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. DM1D8XY RU https://www.fda.gov/ DM28UJG DI DM28UJG DM28UJG DN Dapagliflozin DM28UJG MI DEJGDUW DM28UJG MN Cytochrome P450 1A2 (CYP1A2) DM28UJG MT DME DM28UJG MA Metabolism DM28UJG RN Clinical pharmacokinetics and pharmacodynamics of dapagliflozin, a selective inhibitor of sodium-glucose co-transporter type 2. 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DM28UJG RU https://www.ncbi.nlm.nih.gov/pubmed/?term=24105299 DM28UJG DI DM28UJG DM28UJG DN Dapagliflozin DM28UJG MI DECB0K3 DM28UJG MN Cytochrome P450 2D6 (CYP2D6) DM28UJG MT DME DM28UJG MA Metabolism DM28UJG RN Clinical pharmacokinetics and pharmacodynamics of dapagliflozin, a selective inhibitor of sodium-glucose co-transporter type 2. Clin Pharmacokinet. 2014 Jan;53(1):17-27. DM28UJG RU https://www.ncbi.nlm.nih.gov/pubmed/?term=24105299 DM28UJG DI DM28UJG DM28UJG DN Dapagliflozin DM28UJG MI DE4LYSA DM28UJG MN Cytochrome P450 3A4 (CYP3A4) DM28UJG MT DME DM28UJG MA Metabolism DM28UJG RN Clinical pharmacokinetics and pharmacodynamics of dapagliflozin, a selective inhibitor of sodium-glucose co-transporter type 2. Clin Pharmacokinet. 2014 Jan;53(1):17-27. 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DM28UJG RU https://www.ncbi.nlm.nih.gov/pubmed/?term=24105299 DM28UJG DI DM28UJG DM28UJG DN Dapagliflozin DM28UJG MI DEB3CV1 DM28UJG MN UDP-glucuronosyltransferase 2B7 (UGT2B7) DM28UJG MT DME DM28UJG MA Metabolism DM28UJG RN Clinical pharmacokinetics and pharmacodynamics of dapagliflozin, a selective inhibitor of sodium-glucose co-transporter type 2. Clin Pharmacokinet. 2014 Jan;53(1):17-27. DM28UJG RU https://www.ncbi.nlm.nih.gov/pubmed/?term=24105299 DM34TXO DI DM34TXO DM34TXO DN Dapagliflozin Propanediol; Saxagliptin Hydrochloride DM34TXO MI TTDIGC1 DM34TXO MN Dipeptidyl peptidase 4 (DPP-4) DM34TXO MT DTT DM34TXO MA Modulator DM34TXO RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. DM34TXO RU https://www.fda.gov/ DM34TXO DI DM34TXO DM34TXO DN Dapagliflozin Propanediol; Saxagliptin Hydrochloride DM34TXO MI TTLWPVF DM34TXO MN Sodium/glucose cotransporter 2 (SGLT2) DM34TXO MT DTT DM34TXO MA Modulator DM34TXO RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. DM34TXO RU https://www.fda.gov/ DMOXJKF DI DMOXJKF DMOXJKF DN Dapiprazole DMOXJKF MI TTEX248 DMOXJKF MN Dopamine D2 receptor (D2R) DMOXJKF MT DTT DMOXJKF MA Antagonist DMOXJKF RN Effect of ibopamine on aqueous humor production in normotensive humans. Invest Ophthalmol Vis Sci. 2003 Nov;44(11):4853-8. DMOXJKF RU https://pubmed.ncbi.nlm.nih.gov/14578408 DM4LT8A DI DM4LT8A DM4LT8A DN Dapsone DM4LT8A MI DEZMWRE DM4LT8A MN Cytochrome P450 2C18 (CYP2C18) DM4LT8A MT DME DM4LT8A MA Metabolism DM4LT8A RN CYP2C8/9 mediate dapsone N-hydroxylation at clinical concentrations of dapsone. Drug Metab Dispos. 2000 Aug;28(8):865-8. DM4LT8A RU https://www.ncbi.nlm.nih.gov/pubmed/?term=10901692 DM4LT8A DI DM4LT8A DM4LT8A DN Dapsone DM4LT8A MI DES5XRU DM4LT8A MN Cytochrome P450 2C8 (CYP2C8) DM4LT8A MT DME DM4LT8A MA Metabolism DM4LT8A RN CYP2C8/9 mediate dapsone N-hydroxylation at clinical concentrations of dapsone. Drug Metab Dispos. 2000 Aug;28(8):865-8. DM4LT8A RU https://www.ncbi.nlm.nih.gov/pubmed/?term=10901692 DM4LT8A DI DM4LT8A DM4LT8A DN Dapsone DM4LT8A MI DE5IED8 DM4LT8A MN Cytochrome P450 2C9 (CYP2C9) DM4LT8A MT DME DM4LT8A MA Metabolism DM4LT8A RN Differential activation of CYP2C9 variants by dapsone. Biochem Pharmacol. 2004 May 15;67(10):1831-41. DM4LT8A RU https://www.ncbi.nlm.nih.gov/pubmed/?term=15130760 DM4LT8A DI DM4LT8A DM4LT8A DN Dapsone DM4LT8A MI DEVDYN7 DM4LT8A MN Cytochrome P450 2E1 (CYP2E1) DM4LT8A MT DME DM4LT8A MA Metabolism DM4LT8A RN CYP2C8/9 mediate dapsone N-hydroxylation at clinical concentrations of dapsone. Drug Metab Dispos. 2000 Aug;28(8):865-8. DM4LT8A RU https://www.ncbi.nlm.nih.gov/pubmed/?term=10901692 DM4LT8A DI DM4LT8A DM4LT8A DN Dapsone DM4LT8A MI DE4LYSA DM4LT8A MN Cytochrome P450 3A4 (CYP3A4) DM4LT8A MT DME DM4LT8A MA Metabolism DM4LT8A RN Metabolic interactions of putative cytochrome P4503A substrates with alternative pathways of dapsone metabolism in human liver microsomes. Drug Metab Dispos. 1996 Feb;24(2):164-171. 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DM4LT8A RU https://www.fda.gov/ DM4LT8A DI DM4LT8A DM4LT8A DN Dapsone DM4LT8A MI DE073H6 DM4LT8A MN Prostaglandin G/H synthase 1 (COX-1) DM4LT8A MT DME DM4LT8A MA Metabolism DM4LT8A RN Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. DM4LT8A RU https://www.ncbi.nlm.nih.gov/pubmed/?term=19515014 DM4LT8A DI DM4LT8A DM4LT8A DN Dapsone DM4LT8A MI DE492CE DM4LT8A MN Prostaglandin G/H synthase 2 (COX-2) DM4LT8A MT DME DM4LT8A MA Metabolism DM4LT8A RN Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. DM4LT8A RU https://www.ncbi.nlm.nih.gov/pubmed/?term=19515014 DMKDU16 DI DMKDU16 DMKDU16 DN Daptomycin DMKDU16 MI TT4ILYC DMKDU16 MN Bacterial Dihydropteroate synthetase (Bact folP) DMKDU16 MT DTT DMKDU16 MA Binder DMKDU16 RN Structural transitions as determinants of the action of the calcium-dependent antibiotic daptomycin. Chem Biol. 2004 Jul;11(7):949-57. DMKDU16 RU https://pubmed.ncbi.nlm.nih.gov/15271353 DMFDQ3I DI DMFDQ3I DMFDQ3I DN Daptomycin DMFDQ3I MI DE49HWX DMFDQ3I MN CDP-alcohol phosphatidyltransferase (pgsA) DMFDQ3I MT DME DMFDQ3I MA Metabolism DMFDQ3I RN Mutations in cdsA and pgsA correlate with daptomycin resistance in Streptococcus mitis and S. oralis. Antimicrob Agents Chemother. 2019 Jan 29;63(2). pii: e01531-18. DMFDQ3I RU https://pubmed.ncbi.nlm.nih.gov/30509945 DMFDQ3I DI DMFDQ3I DMFDQ3I DN Daptomycin DMFDQ3I MI DETMA7Z DMFDQ3I MN CDP-alcohol phosphatidyltransferase (pgsA) DMFDQ3I MT DME DMFDQ3I MA Metabolism DMFDQ3I RN Mutations in cdsA and pgsA correlate with daptomycin resistance in Streptococcus mitis and S. oralis. Antimicrob Agents Chemother. 2019 Jan 29;63(2). pii: e01531-18. DMFDQ3I RU https://pubmed.ncbi.nlm.nih.gov/30509945 DMKCIUZ DI DMKCIUZ DMKCIUZ DN Daratumumab DMKCIUZ MI TTPURFN DMKCIUZ MN Cyclic ADP-ribose hydrolase 1 (CD38) DMKCIUZ MT DTT DMKCIUZ RN Targeting CD38 with Daratumumab Monotherapy in Multiple Myeloma. N Engl J Med. 2015 Sep 24;373(13):1207-19. DMKCIUZ RU https://pubmed.ncbi.nlm.nih.gov/26308596 DMMJTYW DI DMMJTYW DMMJTYW DN Darbepoetin alfa DMMJTYW MI TTAUX24 DMMJTYW MN Erythropoietin Receptor (EPOR) DMMJTYW MT DTT DMMJTYW MA Agonist DMMJTYW RN A cytosolic domain of the erythropoietin receptor contributes to endoplasmic reticulum-associated degradation. Eur J Biochem. 1999 Jul;263(2):410-9. DMMJTYW RU https://pubmed.ncbi.nlm.nih.gov/10406949 DMWXLYZ DI DMWXLYZ DMWXLYZ DN Darifenacin DMWXLYZ MI DECB0K3 DMWXLYZ MN Cytochrome P450 2D6 (CYP2D6) DMWXLYZ MT DME DMWXLYZ MA Metabolism DMWXLYZ RN The clinical pharmacokinetics of darifenacin. Clin Pharmacokinet. 2006;45(4):325-50. DMWXLYZ RU https://www.ncbi.nlm.nih.gov/pubmed/?term=16584282 DMWXLYZ DI DMWXLYZ DMWXLYZ DN Darifenacin DMWXLYZ MI DE4LYSA DMWXLYZ MN Cytochrome P450 3A4 (CYP3A4) DMWXLYZ MT DME DMWXLYZ MA Metabolism DMWXLYZ RN The clinical pharmacokinetics of darifenacin. Clin Pharmacokinet. 2006;45(4):325-50. DMWXLYZ RU https://www.ncbi.nlm.nih.gov/pubmed/?term=16584282 DMWXLYZ DI DMWXLYZ DMWXLYZ DN Darifenacin DMWXLYZ MI TTOXS3C DMWXLYZ MN Muscarinic acetylcholine receptor (CHRM) DMWXLYZ MT DTT DMWXLYZ MA Antagonist DMWXLYZ RN Characterisation of [3H]-darifenacin as a novel radioligand for the study of muscarinic M3 receptors. 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U.S. Department of Health Human Services. 2019 DMV7YFT RU https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/212099Orig1s000lbl.pdf DMV7YFT DI DMV7YFT DMV7YFT DN Darolutamide DMV7YFT MI DE4LYSA DMV7YFT MN Cytochrome P450 3A4 (CYP3A4) DMV7YFT MT DME DMV7YFT MA Metabolism DMV7YFT RN Drug-drug interaction potential of darolutamide: in vitro and clinical studies. Eur J Drug Metab Pharmacokinet. 2019 Dec;44(6):747-759. DMV7YFT RU https://www.ncbi.nlm.nih.gov/pubmed/?term=31571146 DMV7YFT DI DMV7YFT DMV7YFT DN Darolutamide DMV7YFT MI DEYGVN4 DMV7YFT MN UDP-glucuronosyltransferase 1A1 (UGT1A1) DMV7YFT MT DME DMV7YFT MA Metabolism DMV7YFT RN Drug-drug interaction potential of darolutamide: in vitro and clinical studies. Eur J Drug Metab Pharmacokinet. 2019 Dec;44(6):747-759. DMV7YFT RU https://www.ncbi.nlm.nih.gov/pubmed/?term=31571146 DMV7YFT DI DMV7YFT DMV7YFT DN Darolutamide DMV7YFT MI DEF2WXN DMV7YFT MN UDP-glucuronosyltransferase 1A3 (UGT1A3) DMV7YFT MT DME DMV7YFT MA Metabolism DMV7YFT RN Drug-drug interaction potential of darolutamide: in vitro and clinical studies. Eur J Drug Metab Pharmacokinet. 2019 Dec;44(6):747-759. DMV7YFT RU https://www.ncbi.nlm.nih.gov/pubmed/?term=31571146 DMV7YFT DI DMV7YFT DMV7YFT DN Darolutamide DMV7YFT MI DE2GB8N DMV7YFT MN UDP-glucuronosyltransferase 1A8 (UGT1A8) DMV7YFT MT DME DMV7YFT MA Metabolism DMV7YFT RN Drug-drug interaction potential of darolutamide: in vitro and clinical studies. Eur J Drug Metab Pharmacokinet. 2019 Dec;44(6):747-759. DMV7YFT RU https://www.ncbi.nlm.nih.gov/pubmed/?term=31571146 DMV7YFT DI DMV7YFT DMV7YFT DN Darolutamide DMV7YFT MI DE85D2P DMV7YFT MN UDP-glucuronosyltransferase 1A9 (UGT1A9) DMV7YFT MT DME DMV7YFT MA Metabolism DMV7YFT RN Drug-drug interaction potential of darolutamide: in vitro and clinical studies. Eur J Drug Metab Pharmacokinet. 2019 Dec;44(6):747-759. DMV7YFT RU https://www.ncbi.nlm.nih.gov/pubmed/?term=31571146 DMV7YFT DI DMV7YFT DMV7YFT DN Darolutamide DMV7YFT MI DEAZDL8 DMV7YFT MN UDP-glucuronosyltransferase 2B17 (UGT2B17) DMV7YFT MT DME DMV7YFT MA Metabolism DMV7YFT RN Drug-drug interaction potential of darolutamide: in vitro and clinical studies. Eur J Drug Metab Pharmacokinet. 2019 Dec;44(6):747-759. DMV7YFT RU https://www.ncbi.nlm.nih.gov/pubmed/?term=31571146 DMN3GCH DI DMN3GCH DMN3GCH DN Darunavir DMN3GCH MI DE4LYSA DMN3GCH MN Cytochrome P450 3A4 (CYP3A4) DMN3GCH MT DME DMN3GCH MA Metabolism DMN3GCH RN Drug interactions with new and investigational antiretrovirals. Clin Pharmacokinet. 2009;48(4):211-41. DMN3GCH RU https://www.ncbi.nlm.nih.gov/pubmed/?term=19492868 DMN3GCH DI DMN3GCH DMN3GCH DN Darunavir DMN3GCH MI TT5FNQT DMN3GCH MN Human immunodeficiency virus Protease (HIV PR) DMN3GCH MT DTT DMN3GCH MA Modulator DMN3GCH RN 2006 drug approvals: finding the niche. Nat Rev Drug Discov. 2007 Feb;6(2):99-101. DMN3GCH RU https://pubmed.ncbi.nlm.nih.gov/17342860 DMN3GCH DI DMN3GCH DMN3GCH DN Darunavir DMN3GCH MI DTE2B1D DMN3GCH MN Organic anion transporting polypeptide 1A2 (SLCO1A2) DMN3GCH MT DTP DMN3GCH MA Substrate DMN3GCH RN P-glycoprotein mediates efflux transport of darunavir in human intestinal Caco-2 and ABCB1 gene-transfected renal LLC-PK1 cell lines. Biol Pharm Bull. 2009 Sep;32(9):1588-93. DMN3GCH RU https://doi.org/10.1248/bpb.32.1588 DMN3GCH DI DMN3GCH DMN3GCH DN Darunavir DMN3GCH MI DT3D8F0 DMN3GCH MN Organic anion transporting polypeptide 1B1 (SLCO1B1) DMN3GCH MT DTP DMN3GCH MA Substrate DMN3GCH RN Organic anion transporting polypeptide 1B1: a genetically polymorphic transporter of major importance for hepatic drug uptake. Pharmacol Rev. 2011 Mar;63(1):157-81. DMN3GCH RU http://www.ncbi.nlm.nih.gov/pubmed/21245207 DMN3GCH DI DMN3GCH DMN3GCH DN Darunavir DMN3GCH MI DTUGYRD DMN3GCH MN P-glycoprotein 1 (ABCB1) DMN3GCH MT DTP DMN3GCH MA Substrate DMN3GCH RN Impact of drug transporters on cellular resistance towards saquinavir and darunavir. J Antimicrob Chemother. 2010 Nov;65(11):2319-28. DMN3GCH RU https://doi.org/10.1093/jac/dkq324 DMJV2EK DI DMJV2EK DMJV2EK DN Dasatinib DMJV2EK MI DTI7UX6 DMJV2EK MN Breast cancer resistance protein (ABCG2) DMJV2EK MT DTP DMJV2EK MA Substrate DMJV2EK RN Interaction of nilotinib, dasatinib and bosutinib with ABCB1 and ABCG2: implications for altered anti-cancer effects and pharmacological properties. Br J Pharmacol. 2009 Oct;158(4):1153-64. DMJV2EK RU http://www.ncbi.nlm.nih.gov/pubmed/19785662 DMJV2EK DI DMJV2EK DMJV2EK DN Dasatinib DMJV2EK MI DEJGDUW DMJV2EK MN Cytochrome P450 1A2 (CYP1A2) DMJV2EK MT DME DMJV2EK MA Metabolism DMJV2EK RN Clinical pharmacokinetics of tyrosine kinase inhibitors. Cancer Treat Rev. 2009 Dec;35(8):692-706. DMJV2EK RU https://www.ncbi.nlm.nih.gov/pubmed/?term=19733976 DMJV2EK DI DMJV2EK DMJV2EK DN Dasatinib DMJV2EK MI DE4LYSA DMJV2EK MN Cytochrome P450 3A4 (CYP3A4) DMJV2EK MT DME DMJV2EK MA Metabolism DMJV2EK RN Clinical pharmacokinetics of tyrosine kinase inhibitors. Cancer Treat Rev. 2009 Dec;35(8):692-706. DMJV2EK RU https://www.ncbi.nlm.nih.gov/pubmed/?term=19733976 DMJV2EK DI DMJV2EK DMJV2EK DN Dasatinib DMJV2EK MI DEIBDNY DMJV2EK MN Cytochrome P450 3A5 (CYP3A5) DMJV2EK MT DME DMJV2EK MA Metabolism DMJV2EK RN Clinical pharmacokinetics of tyrosine kinase inhibitors. Cancer Treat Rev. 2009 Dec;35(8):692-706. DMJV2EK RU https://www.ncbi.nlm.nih.gov/pubmed/?term=19733976 DMJV2EK DI DMJV2EK DMJV2EK DN Dasatinib DMJV2EK MI DEP76YL DMJV2EK MN Dimethylaniline oxidase 3 (FMO3) DMJV2EK MT DME DMJV2EK MA Metabolism DMJV2EK RN Identification of the human enzymes involved in the oxidative metabolism of dasatinib: an effective approach for determining metabolite formation kinetics. Drug Metab Dispos. 2008 Sep;36(9):1828-39. DMJV2EK RU https://www.ncbi.nlm.nih.gov/pubmed/?term=18556438 DMJV2EK DI DMJV2EK DMJV2EK DN Dasatinib DMJV2EK MI TTS7G69 DMJV2EK MN Fusion protein Bcr-Abl (Bcr-Abl) DMJV2EK MT DTT DMJV2EK MA Inhibitor DMJV2EK RN A comparison of physicochemical property profiles of marketed oral drugs and orally bioavailable anti-cancer protein kinase inhibitors in clinical development. Curr Top Med Chem. 2007;7(14):1408-22. DMJV2EK RU https://pubmed.ncbi.nlm.nih.gov/17692029 DMJV2EK DI DMJV2EK DMJV2EK DN Dasatinib DMJV2EK MI TT2B9KF DMJV2EK MN Fyn tyrosine protein kinase (FYN) DMJV2EK MT DTT DMJV2EK MA Inhibitor DMJV2EK RN A comparison of physicochemical property profiles of marketed oral drugs and orally bioavailable anti-cancer protein kinase inhibitors in clinical development. Curr Top Med Chem. 2007;7(14):1408-22. DMJV2EK RU https://pubmed.ncbi.nlm.nih.gov/17692029 DMJV2EK DI DMJV2EK DMJV2EK DN Dasatinib DMJV2EK MI TT860QF DMJV2EK MN LCK tyrosine protein kinase (LCK) DMJV2EK MT DTT DMJV2EK MA Inhibitor DMJV2EK RN A comparison of physicochemical property profiles of marketed oral drugs and orally bioavailable anti-cancer protein kinase inhibitors in clinical development. Curr Top Med Chem. 2007;7(14):1408-22. DMJV2EK RU https://pubmed.ncbi.nlm.nih.gov/17692029 DMJV2EK DI DMJV2EK DMJV2EK DN Dasatinib DMJV2EK MI DT3D8F0 DMJV2EK MN Organic anion transporting polypeptide 1B1 (SLCO1B1) DMJV2EK MT DTP DMJV2EK MA Substrate DMJV2EK RN Contribution of OATP1B1 and OATP1B3 to the disposition of sorafenib and sorafenib-glucuronide. Clin Cancer Res. 2013 Mar 15;19(6):1458-66. DMJV2EK RU http://www.ncbi.nlm.nih.gov/pubmed/23340295 DMJV2EK DI DMJV2EK DMJV2EK DN Dasatinib DMJV2EK MI DT9C1TS DMJV2EK MN Organic anion transporting polypeptide 1B3 (SLCO1B3) DMJV2EK MT DTP DMJV2EK MA Substrate DMJV2EK RN Contribution of OATP1B1 and OATP1B3 to the disposition of sorafenib and sorafenib-glucuronide. Clin Cancer Res. 2013 Mar 15;19(6):1458-66. DMJV2EK RU http://www.ncbi.nlm.nih.gov/pubmed/23340295 DMJV2EK DI DMJV2EK DMJV2EK DN Dasatinib DMJV2EK MI DTUGYRD DMJV2EK MN P-glycoprotein 1 (ABCB1) DMJV2EK MT DTP DMJV2EK MA Substrate DMJV2EK RN Comparison of ATP-binding cassette transporter interactions with the tyrosine kinase inhibitors imatinib, nilotinib, and dasatinib. Drug Metab Dispos. 2010 Aug;38(8):1371-80. DMJV2EK RU http://www.ncbi.nlm.nih.gov/pubmed/20423956 DMJV2EK DI DMJV2EK DMJV2EK DN Dasatinib DMJV2EK MI TT6PKBN DMJV2EK MN Proto-oncogene c-Src (SRC) DMJV2EK MT DTT DMJV2EK MA Inhibitor DMJV2EK RN A comparison of physicochemical property profiles of marketed oral drugs and orally bioavailable anti-cancer protein kinase inhibitors in clinical development. Curr Top Med Chem. 2007;7(14):1408-22. DMJV2EK RU https://pubmed.ncbi.nlm.nih.gov/17692029 DM74SVE DI DM74SVE DM74SVE DN Dasiglucagon DM74SVE MI TT9O6WS DM74SVE MN Glucagon receptor (GCGR) DM74SVE MT DTT DM74SVE MA Agonist DM74SVE RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health Human Services. 2021 DM74SVE RU https://www.accessdata.fda.gov/drugsatfda_docs/label/2021/214231s000lbl.pdf DMLDQFV DI DMLDQFV DMLDQFV DN Dasotraline DMLDQFV MI TTVBI8W DMLDQFV MN Dopamine transporter (DAT) DMLDQFV MT DTT DMLDQFV MA Inhibitor DMLDQFV RN Dasotraline for the Treatment of Attention-Deficit/Hyperactivity Disorder: A Randomized, Double-Blind, Placebo-Controlled, Proof-of-Concept Trial in Adults. Neuropsychopharmacology. 2015 Nov;40(12):2745-52. DMLDQFV RU https://pubmed.ncbi.nlm.nih.gov/25948101 DMLDQFV DI DMLDQFV DMLDQFV DN Dasotraline DMLDQFV MI TTAWNKZ DMLDQFV MN Norepinephrine transporter (NET) DMLDQFV MT DTT DMLDQFV MA Inhibitor DMLDQFV RN Dasotraline for the Treatment of Attention-Deficit/Hyperactivity Disorder: A Randomized, Double-Blind, Placebo-Controlled, Proof-of-Concept Trial in Adults. Neuropsychopharmacology. 2015 Nov;40(12):2745-52. DMLDQFV RU https://pubmed.ncbi.nlm.nih.gov/25948101 DMLDQFV DI DMLDQFV DMLDQFV DN Dasotraline DMLDQFV MI TT3ROYC DMLDQFV MN Serotonin transporter (SERT) DMLDQFV MT DTT DMLDQFV MA Inhibitor DMLDQFV RN Dasotraline for the Treatment of Attention-Deficit/Hyperactivity Disorder: A Randomized, Double-Blind, Placebo-Controlled, Proof-of-Concept Trial in Adults. Neuropsychopharmacology. 2015 Nov;40(12):2745-52. 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DMQUSBT RU http://www.ncbi.nlm.nih.gov/pubmed/11437380 DMQUSBT DI DMQUSBT DMQUSBT DN Daunorubicin DMQUSBT MI DE6OQ3W DMQUSBT MN Cytochrome P450 1A1 (CYP1A1) DMQUSBT MT DME DMQUSBT MA Metabolism DMQUSBT RN The effect of new lipophilic chelators on the activities of cytosolic reductases and P450 cytochromes involved in the metabolism of anthracycline antibiotics: studies in vitro. Physiol Res. 2004;53(6):683-91. DMQUSBT RU https://www.ncbi.nlm.nih.gov/pubmed/?term=15588138 DMQUSBT DI DMQUSBT DMQUSBT DN Daunorubicin DMQUSBT MI DEJGDUW DMQUSBT MN Cytochrome P450 1A2 (CYP1A2) DMQUSBT MT DME DMQUSBT MA Metabolism DMQUSBT RN The effect of new lipophilic chelators on the activities of cytosolic reductases and P450 cytochromes involved in the metabolism of anthracycline antibiotics: studies in vitro. Physiol Res. 2004;53(6):683-91. 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DMQUSBT RU https://www.fda.gov/ DMQUSBT DI DMQUSBT DMQUSBT DN Daunorubicin DMQUSBT MI TTUTN1I DMQUSBT MN Human Deoxyribonucleic acid (hDNA) DMQUSBT MT DTT DMQUSBT MA Intercalator DMQUSBT RN 31P NMR spectra of ethidium, quinacrine, and daunomycin complexes with poly(adenylic acid).poly(uridylic acid) RNA duplex and calf thymus DNA. Biochemistry. 1989 Apr 4;28(7):2804-12. DMQUSBT RU https://pubmed.ncbi.nlm.nih.gov/2472832 DMQUSBT DI DMQUSBT DMQUSBT DN Daunorubicin DMQUSBT MI DTSYQGK DMQUSBT MN Multidrug resistance-associated protein 1 (ABCC1) DMQUSBT MT DTP DMQUSBT MA Substrate DMQUSBT RN Vinblastine and sulfinpyrazone export by the multidrug resistance protein MRP2 is associated with glutathione export. Br J Cancer. 2000 Aug;83(3):375-83. 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DMC50ME RU http://www.ncbi.nlm.nih.gov/pubmed/10213372 DMSBRUW DI DMSBRUW DMSBRUW DN Decamethonium DMSBRUW MI TT54JVQ DMSBRUW MN Neuronal acetylcholine receptor alpha-1 (CHRNA1) DMSBRUW MT DTT DMSBRUW MA Modulator DMSBRUW RN Potency of nondepolarizing muscle relaxants on muscle-type acetylcholine receptors in denervated mouse skeletal muscle.Acta Pharmacol Sin.2010 Dec;31(12):1541-6. DMSBRUW RU https://www.ncbi.nlm.nih.gov/pubmed/21102480 DMQL8XJ DI DMQL8XJ DMQL8XJ DN Decitabine DMQL8XJ MI DEKEDRC DMQL8XJ MN Cytidine aminohydrolase (CDA) DMQL8XJ MT DME DMQL8XJ MA Metabolism DMQL8XJ RN Tracking decitabine incorporation into malignant myeloid cell DNA in vitro and in vivo by LC-MS/MS with enzymatic digestion. Sci Rep. 2019 Mar 14;9(1):4558. DMQL8XJ RU https://www.ncbi.nlm.nih.gov/pubmed/?term=30872721 DMQL8XJ DI DMQL8XJ DMQL8XJ DN Decitabine DMQL8XJ MI DEYILK4 DMQL8XJ MN Cytidine deaminase (cdd) DMQL8XJ MT DME DMQL8XJ MA Metabolism DMQL8XJ RN Mycoplasma hyorhinis-encoded cytidine deaminase efficiently inactivates cytosine-based anticancer drugs. FEBS Open Bio. 2015 Aug 3;5:634-9. DMQL8XJ RU https://pubmed.ncbi.nlm.nih.gov/26322268 DMQL8XJ DI DMQL8XJ DMQL8XJ DN Decitabine DMQL8XJ MI TTUTN1I DMQL8XJ MN Human Deoxyribonucleic acid (hDNA) DMQL8XJ MT DTT DMQL8XJ MA Modulator DMQL8XJ RN 2006 drug approvals: finding the niche. Nat Rev Drug Discov. 2007 Feb;6(2):99-101. DMQL8XJ RU https://pubmed.ncbi.nlm.nih.gov/17342860 DM6ETS0 DI DM6ETS0 DM6ETS0 DN Deferasirox DM6ETS0 MI DEYGVN4 DM6ETS0 MN UDP-glucuronosyltransferase 1A1 (UGT1A1) DM6ETS0 MT DME DM6ETS0 MA Metabolism DM6ETS0 RN Deferasirox pharmacogenetic influence on pharmacokinetic, efficacy and toxicity in a cohort of pediatric patients. Pharmacogenomics. 2017 Apr;18(6):539-554. DM6ETS0 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=28346059 DM6ETS0 DI DM6ETS0 DM6ETS0 DN Deferasirox DM6ETS0 MI DEF2WXN DM6ETS0 MN UDP-glucuronosyltransferase 1A3 (UGT1A3) DM6ETS0 MT DME DM6ETS0 MA Metabolism DM6ETS0 RN Deferasirox pharmacogenetic influence on pharmacokinetic, efficacy and toxicity in a cohort of pediatric patients. Pharmacogenomics. 2017 Apr;18(6):539-554. DM6ETS0 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=28346059 DMS2M7O DI DMS2M7O DMS2M7O DN Deferiprone DMS2M7O MI TTUDR0C DMS2M7O MN Iron (Fe) DMS2M7O MT DTT DMS2M7O MA Modulator DMS2M7O RN 2011 FDA drug approvals. Nat Rev Drug Discov. 2012 Feb 1;11(2):91-4. DMS2M7O RU https://pubmed.ncbi.nlm.nih.gov/22293555 DMS2M7O DI DMS2M7O DMS2M7O DN Deferiprone DMS2M7O MI DESD26P DMS2M7O MN UDP-glucuronosyltransferase 1A6 (UGT1A6) DMS2M7O MT DME DMS2M7O MA Metabolism DMS2M7O RN Deferiprone glucuronidation by human tissues and recombinant UDP glucuronosyltransferase 1A6: an in vitro investigation of genetic and splice variants. Drug Metab Dispos. 2009 Feb;37(2):322-9. DMS2M7O RU https://www.ncbi.nlm.nih.gov/pubmed/?term=18971318 DMTUKZH DI DMTUKZH DMTUKZH DN Deferoxamine mesylate DMTUKZH MI TTUDR0C DMTUKZH MN Iron (Fe) DMTUKZH MT DTT DMTUKZH MA Modulator DMTUKZH RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. DMTUKZH RU https://www.fda.gov/ DMV0RNS DI DMV0RNS DMV0RNS DN Deflazacort DMV0RNS MI DE4LYSA DMV0RNS MN Cytochrome P450 3A4 (CYP3A4) DMV0RNS MT DME DMV0RNS MA Metabolism DMV0RNS RN Mechanisms and clinical significance of pharmacokinetic-based drug-drug interactions with drugs approved by the U.S. Food and Drug Administration in 2017. Drug Metab Dispos. 2019 Feb;47(2):135-144. DMV0RNS RU https://www.ncbi.nlm.nih.gov/pubmed/?term=30442649 DMV0RNS DI DMV0RNS DMV0RNS DN Deflazacort DMV0RNS MI TTYRL6O DMV0RNS MN Glucocorticoid receptor (NR3C1) DMV0RNS MT DTT DMV0RNS MA Modulator DMV0RNS RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. DMV0RNS RU https://www.fda.gov/ DMV0RNS DI DMV0RNS DMV0RNS DN Deflazacort DMV0RNS MI DTUGYRD DMV0RNS MN P-glycoprotein 1 (ABCB1) DMV0RNS MT DTP DMV0RNS MA Substrate DMV0RNS RN KEGG: new perspectives on genomes, pathways, diseases and drugs. Nucleic Acids Res. 2017 Jan 4;45(D1):D353-D361. (dg:DG01665) DMV0RNS RU https://www.kegg.jp/dbget-bin/www_bget?dg:DG01665 DM3O8QY DI DM3O8QY DM3O8QY DN Degarelix DM3O8QY MI TT8R70G DM3O8QY MN Gonadotropin-releasing hormone receptor (GNRHR) DM3O8QY MT DTT DM3O8QY MA Inhibitor DM3O8QY RN Iterative approach to the discovery of novel degarelix analogues: substitutions at positions 3, 7, and 8. Part II. J Med Chem. 2005 Jul 28;48(15):4851-60. DM3O8QY RU https://pubmed.ncbi.nlm.nih.gov/16033265 DM4Q80H DI DM4Q80H DM4Q80H DN Dehydroepiandrosterone sulfate DM4Q80H MI DTI7UX6 DM4Q80H MN Breast cancer resistance protein (ABCG2) DM4Q80H MT DTP DM4Q80H MA Substrate DM4Q80H RN A prediction model of substrates and non-substrates of breast cancer resistance protein (BCRP) developed by GA-CG-SVM method. Comput Biol Med. 2011 Nov;41(11):1006-13. DM4Q80H RU https://doi.org/10.1016/j.compbiomed.2011.08.009 DM4Q80H DI DM4Q80H DM4Q80H DN Dehydroepiandrosterone sulfate DM4Q80H MI DTSYQGK DM4Q80H MN Multidrug resistance-associated protein 1 (ABCC1) DM4Q80H MT DTP DM4Q80H MA Substrate DM4Q80H RN Steroid and bile acid conjugates are substrates of human multidrug-resistance protein (MRP) 4 (ATP-binding cassette C4). Biochem J. 2003 Apr 15;371(Pt 2):361-7. DM4Q80H RU http://www.ncbi.nlm.nih.gov/pubmed/12523936 DM4Q80H DI DM4Q80H DM4Q80H DN Dehydroepiandrosterone sulfate DM4Q80H MI DTFI42L DM4Q80H MN Multidrug resistance-associated protein 2 (ABCC2) DM4Q80H MT DTP DM4Q80H MA Substrate DM4Q80H RN Directional trans-epithelial transport of organic anions in porcine LLC-PK1 cells that co-express human OATP1B1 (OATP-C) and MRP2. Biochem Pharmacol. 2005 Feb 1;69(3):415-23. DM4Q80H RU http://www.ncbi.nlm.nih.gov/pubmed/15652233 DM4Q80H DI DM4Q80H DM4Q80H DN Dehydroepiandrosterone sulfate DM4Q80H MI DTQ3ZHF DM4Q80H MN Multidrug resistance-associated protein 3 (ABCC3) DM4Q80H MT DTP DM4Q80H MA Substrate DM4Q80H RN Integration of hepatic drug transporters and phase II metabolizing enzymes: mechanisms of hepatic excretion of sulfate, glucuronide, and glutathione metabolites. Eur J Pharm Sci. 2006 Apr;27(5):447-86. DM4Q80H RU https://doi.org/10.1016/j.ejps.2005.12.007 DM4Q80H DI DM4Q80H DM4Q80H DN Dehydroepiandrosterone sulfate DM4Q80H MI DTCSGPB DM4Q80H MN Multidrug resistance-associated protein 4 (ABCC4) DM4Q80H MT DTP DM4Q80H MA Substrate DM4Q80H RN Steroid and bile acid conjugates are substrates of human multidrug-resistance protein (MRP) 4 (ATP-binding cassette C4). Biochem J. 2003 Apr 15;371(Pt 2):361-7. DM4Q80H RU http://www.ncbi.nlm.nih.gov/pubmed/12523936 DM4Q80H DI DM4Q80H DM4Q80H DN Dehydroepiandrosterone sulfate DM4Q80H MI DTE2B1D DM4Q80H MN Organic anion transporting polypeptide 1A2 (SLCO1A2) DM4Q80H MT DTP DM4Q80H MA Substrate DM4Q80H RN Membrane transporters in drug development. Nat Rev Drug Discov. 2010 Mar;9(3):215-36. DM4Q80H RU https://doi.org/10.1038/nrd3028 DM4Q80H DI DM4Q80H DM4Q80H DN Dehydroepiandrosterone sulfate DM4Q80H MI DT3D8F0 DM4Q80H MN Organic anion transporting polypeptide 1B1 (SLCO1B1) DM4Q80H MT DTP DM4Q80H MA Substrate DM4Q80H RN Organic anion transporting polypeptide 1B1: a genetically polymorphic transporter of major importance for hepatic drug uptake. Pharmacol Rev. 2011 Mar;63(1):157-81. DM4Q80H RU http://www.ncbi.nlm.nih.gov/pubmed/21245207 DM4Q80H DI DM4Q80H DM4Q80H DN Dehydroepiandrosterone sulfate DM4Q80H MI DT9C1TS DM4Q80H MN Organic anion transporting polypeptide 1B3 (SLCO1B3) DM4Q80H MT DTP DM4Q80H MA Substrate DM4Q80H RN LST-2, a human liver-specific organic anion transporter, determines methotrexate sensitivity in gastrointestinal cancers. Gastroenterology. 2001 Jun;120(7):1689-99. DM4Q80H RU http://www.ncbi.nlm.nih.gov/pubmed/11375950 DM4Q80H DI DM4Q80H DM4Q80H DN Dehydroepiandrosterone sulfate DM4Q80H MI DTPFTEQ DM4Q80H MN Organic anion transporting polypeptide 2B1 (SLCO2B1) DM4Q80H MT DTP DM4Q80H MA Substrate DM4Q80H RN Expression of OATP family members in hormone-related cancers: potential markers of progression. PLoS One. 2011;6(5):e20372. DM4Q80H RU https://doi.org/10.1371/journal.pone.0020372 DMVTU5Q DI DMVTU5Q DMVTU5Q DN Delafloxacin Meglumine DMVTU5Q MI TTZ82MR DMVTU5Q MN Plasmodium DNA gyrase (Malaria gyrase) DMVTU5Q MT DTT DMVTU5Q MA Inhibitor DMVTU5Q RN 2017 FDA drug approvals.Nat Rev Drug Discov. 2018 Feb;17(2):81-85. DMVTU5Q RU https://pubmed.ncbi.nlm.nih.gov/29348678 DMVTU5Q DI DMVTU5Q DMVTU5Q DN Delafloxacin Meglumine DMVTU5Q MI TTIXTO3 DMVTU5Q MN Staphylococcus Topoisomerase IV (Stap-coc parC) DMVTU5Q MT DTT DMVTU5Q MA Inhibitor DMVTU5Q RN 2017 FDA drug approvals.Nat Rev Drug Discov. 2018 Feb;17(2):81-85. DMVTU5Q RU https://pubmed.ncbi.nlm.nih.gov/29348678 DMXE76K DI DMXE76K DMXE76K DN Delamanid DMXE76K MI TTXT4D5 DMXE76K MN Bacterial Cell membrane (Bact CM) DMXE76K MT DTT DMXE76K MA Inhibitor DMXE76K RN Compassionate use of delamanid in adults and children for drug-resistant tuberculosis: 5-year update. Eur Respir J. 2021 May 20;57(5):2002483. DMXE76K RU https://pubmed.ncbi.nlm.nih.gov/33243846 DMXE76K DI DMXE76K DMXE76K DN Delamanid DMXE76K MI DE4LYSA DMXE76K MN Cytochrome P450 3A4 (CYP3A4) DMXE76K MT DME DMXE76K MA Metabolism DMXE76K RN Pharmacokinetics and metabolism of delamanid, a novel anti-tuberculosis drug, in animals and humans: importance of albumin metabolism in vivo. Drug Metab Dispos. 2015 Aug;43(8):1267-76. DMXE76K RU https://www.ncbi.nlm.nih.gov/pubmed/?term=26055620 DM7EUK3 DI DM7EUK3 DM7EUK3 DN Delapril DM7EUK3 MI TTL69WB DM7EUK3 MN Angiotensin-converting enzyme (ACE) DM7EUK3 MT DTT DM7EUK3 MA Modulator DM7EUK3 RN Natural products as sources of new drugs over the last 25 years. J Nat Prod. 2007 Mar;70(3):461-77. DM7EUK3 RU https://pubmed.ncbi.nlm.nih.gov/17309302 DM3NF5G DI DM3NF5G DM3NF5G DN Delavirdine DM3NF5G MI DTI7UX6 DM3NF5G MN Breast cancer resistance protein (ABCG2) DM3NF5G MT DTP DM3NF5G MA Substrate DM3NF5G RN Mammalian drug efflux transporters of the ATP binding cassette (ABC) family in multidrug resistance: A review of the past decade. Cancer Lett. 2016 Jan 1;370(1):153-64. DM3NF5G RU http://www.ncbi.nlm.nih.gov/pubmed/26499806 DM3NF5G DI DM3NF5G DM3NF5G DN Delavirdine DM3NF5G MI DECB0K3 DM3NF5G MN Cytochrome P450 2D6 (CYP2D6) DM3NF5G MT DME DM3NF5G MA Metabolism DM3NF5G RN Inhibition of human cytochrome P450 isoforms by nonnucleoside reverse transcriptase inhibitors. J Clin Pharmacol. 2001 Jan;41(1):85-91. DM3NF5G RU https://www.ncbi.nlm.nih.gov/pubmed/?term=11225565 DM3NF5G DI DM3NF5G DM3NF5G DN Delavirdine DM3NF5G MI DE4LYSA DM3NF5G MN Cytochrome P450 3A4 (CYP3A4) DM3NF5G MT DME DM3NF5G MA Metabolism DM3NF5G RN Delavirdine: clinical pharmacokinetics and drug interactions. Clin Pharmacokinet. 2001;40(3):207-26. DM3NF5G RU https://www.ncbi.nlm.nih.gov/pubmed/?term=11327199 DM3NF5G DI DM3NF5G DM3NF5G DN Delavirdine DM3NF5G MI DEIBDNY DM3NF5G MN Cytochrome P450 3A5 (CYP3A5) DM3NF5G MT DME DM3NF5G MA Metabolism DM3NF5G RN Drug Interactions Flockhart Table DM3NF5G RU https://drug-interactions.medicine.iu.edu/Main-Table.aspx DM3NF5G DI DM3NF5G DM3NF5G DN Delavirdine DM3NF5G MI DERD86B DM3NF5G MN Cytochrome P450 3A7 (CYP3A7) DM3NF5G MT DME DM3NF5G MA Metabolism DM3NF5G RN Drug Interactions Flockhart Table DM3NF5G RU https://drug-interactions.medicine.iu.edu/Main-Table.aspx DM3NF5G DI DM3NF5G DM3NF5G DN Delavirdine DM3NF5G MI TT84ETX DM3NF5G MN Human immunodeficiency virus Reverse transcriptase (HIV RT) DM3NF5G MT DTT DM3NF5G MA Modulator DM3NF5G RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. DM3NF5G RU https://www.fda.gov/ DM3NF5G DI DM3NF5G DM3NF5G DN Delavirdine DM3NF5G MI DTUGYRD DM3NF5G MN P-glycoprotein 1 (ABCB1) DM3NF5G MT DTP DM3NF5G MA Substrate DM3NF5G RN The transport of anti-HIV drugs across blood-CNS interfaces: summary of current knowledge and recommendations for further research. Antiviral Res. 2009 May;82(2):A99-109. DM3NF5G RU https://doi.org/10.1016/j.antiviral.2008.12.013 DMAYEU1 DI DMAYEU1 DMAYEU1 DN Demecarium bromide DMAYEU1 MI TT1RS9F DMAYEU1 MN Acetylcholinesterase (AChE) DMAYEU1 MT DTT DMAYEU1 MA Inhibitor DMAYEU1 RN The effects of topical ocular application of 0.25% demecarium bromide on serum acetylcholinesterase levels in normal dogs. Vet Ophthalmol. 2003 Mar;6(1):23-5. DMAYEU1 RU https://pubmed.ncbi.nlm.nih.gov/12641839 DMZEPFJ DI DMZEPFJ DMZEPFJ DN Demeclocycline DMZEPFJ MI TTQ8KVI DMZEPFJ MN Staphylococcus 30S ribosomal subunit (Stap-coc pbp2) DMZEPFJ MT DTT DMZEPFJ MA Binder DMZEPFJ RN Detection of tetracycline resistance genes by PCR methods. Methods Mol Biol. 2004;268:3-13. DMZEPFJ RU https://pubmed.ncbi.nlm.nih.gov/15156014 DMCZQGK DI DMCZQGK DMCZQGK DN Demecolcine DMCZQGK MI TT1EDJZ DMCZQGK MN Microtubule-associated protein (MAP) DMCZQGK MT DTT DMCZQGK MA Modulator DMCZQGK RN Medicinal plants in therapy. Bull World Health Organ. 1985;63(6):965-81. DMCZQGK RU https://pubmed.ncbi.nlm.nih.gov/3879679 DMMHR1U DI DMMHR1U DMMHR1U DN Denileukin diftitox DMMHR1U MI TTAJU0S DMMHR1U MN Interleukin 2 receptor (IL2R) DMMHR1U MT DTT DMMHR1U MA Binder DMMHR1U RN Optimizing denileukin diftitox (Ontak) therapy. Future Oncol. 2008 Aug;4(4):457-69. DMMHR1U RU https://pubmed.ncbi.nlm.nih.gov/18684057 DM8C3GN DI DM8C3GN DM8C3GN DN Denopamine DM8C3GN MI TTEX248 DM8C3GN MN Dopamine D2 receptor (D2R) DM8C3GN MT DTT DM8C3GN MA Modulator DM8C3GN RN Natural products as sources of new drugs over the last 25 years. J Nat Prod. 2007 Mar;70(3):461-77. DM8C3GN RU https://pubmed.ncbi.nlm.nih.gov/17309302 DM8C3GN DI DM8C3GN DM8C3GN DN Denopamine DM8C3GN MI DEAZDL8 DM8C3GN MN UDP-glucuronosyltransferase 2B17 (UGT2B17) DM8C3GN MT DME DM8C3GN MA Metabolism DM8C3GN RN Regioselective glucuronidation of denopamine: marked species differences and identification of human udp-glucuronosyltransferase isoform. Drug Metab Dispos. 2005 Mar;33(3):403-12. DM8C3GN RU https://www.ncbi.nlm.nih.gov/pubmed/?term=15608137 DMNI0KO DI DMNI0KO DMNI0KO DN Denosumab DMNI0KO MI TT9E8HR DMNI0KO MN Osteoclast differentiation factor (ODF) DMNI0KO MT DTT DMNI0KO RN Mullard A: 2010 FDA drug approvals. Nat Rev Drug Discov. 2011 Feb;10(2):82-5. DMNI0KO RU https://pubmed.ncbi.nlm.nih.gov/21283092 DM3GYAL DI DM3GYAL DM3GYAL DN Deoxycholic acid DM3GYAL MI DT7JELC DM3GYAL MN Apical sodium-dependent bile acid transporter (SLC10A2) DM3GYAL MT DTP DM3GYAL MA Substrate DM3GYAL RN Functional nanoparticles exploit the bile acid pathway to overcome multiple barriers of the intestinal epithelium for oral insulin delivery. Biomaterials. 2018 Jan;151:13-23. DM3GYAL RU http://www.ncbi.nlm.nih.gov/pubmed/29055774 DM3GYAL DI DM3GYAL DM3GYAL DN Deoxycholic acid DM3GYAL MI DTI7UX6 DM3GYAL MN Breast cancer resistance protein (ABCG2) DM3GYAL MT DTP DM3GYAL MA Substrate DM3GYAL RN Arginine-482 is not essential for transport of antibiotics, primary bile acids and unconjugated sterols by the human breast cancer resistance protein (ABCG2). Biochem J. 2005 Jan 15;385(Pt 2):419-26. DM3GYAL RU https://doi.org/10.1042/BJ20040791 DMYE5LJ DI DMYE5LJ DMYE5LJ DN DEOXYCYTIDINE DMYE5LJ MI TTP3QRF DMYE5LJ MN Thymidine kinase 1 (TK1) DMYE5LJ MT DTT DMYE5LJ MA Inhibitor DMYE5LJ RN Species- or isozyme-specific enzyme inhibitors. 5. Differential effects of thymidine substituents on affinity for rat thymidine kinase isozymes. J Med Chem. 1982 Jun;25(6):644-9. DMYE5LJ RU https://pubmed.ncbi.nlm.nih.gov/7097717 DMRH7CV DI DMRH7CV DMRH7CV DN Deserpidine DMRH7CV MI TTL69WB DMRH7CV MN Angiotensin-converting enzyme (ACE) DMRH7CV MT DTT DMRH7CV MA Inhibitor DMRH7CV RN Angiotensin II-induced modulation of endothelium-dependent relaxation in rabbit mesenteric resistance arteries. J Physiol. 2003 May 1;548(Pt 3):893-906. DMRH7CV RU https://pubmed.ncbi.nlm.nih.gov/12651915 DM2TO9R DI DM2TO9R DM2TO9R DN Desflurane DM2TO9R MI TTAN6JD DM2TO9R MN Glutamate receptor AMPA (GRIA) DM2TO9R MT DTT DM2TO9R MA Antagonist DM2TO9R RN Modulation of NMDA receptor function by ketamine and magnesium. Part II: interactions with volatile anesthetics. Anesth Analg. 2001 May;92(5):1182-91. DM2TO9R RU https://pubmed.ncbi.nlm.nih.gov/11323344 DMT2FDC DI DMT2FDC DMT2FDC DN Desipramine DMT2FDC MI DEJGDUW DMT2FDC MN Cytochrome P450 1A2 (CYP1A2) DMT2FDC MT DME DMT2FDC MA Metabolism DMT2FDC RN Summary of information on human CYP enzymes: human P450 metabolism data. Drug Metab Rev. 2002 Feb-May;34(1-2):83-448. DMT2FDC RU https://www.ncbi.nlm.nih.gov/pubmed/?term=11996015 DMT2FDC DI DMT2FDC DMT2FDC DN Desipramine DMT2FDC MI DEPKLMQ DMT2FDC MN Cytochrome P450 2B6 (CYP2B6) DMT2FDC MT DME DMT2FDC MA Metabolism DMT2FDC RN Drugs that may have potential CYP2B6 interactions. DMT2FDC RU https://drug-interactions.medicine.iu.edu/MainTable.aspx DMT2FDC DI DMT2FDC DMT2FDC DN Desipramine DMT2FDC MI DECB0K3 DMT2FDC MN Cytochrome P450 2D6 (CYP2D6) DMT2FDC MT DME DMT2FDC MA Metabolism DMT2FDC RN Dose-dependent inhibition of CYP1A2, CYP2C19 and CYP2D6 by citalopram, fluoxetine, fluvoxamine and paroxetine. Eur J Clin Pharmacol. 1996;51(1):73-8. DMT2FDC RU https://www.ncbi.nlm.nih.gov/pubmed/?term=8880055 DMT2FDC DI DMT2FDC DMT2FDC DN Desipramine DMT2FDC MI DE4LYSA DMT2FDC MN Cytochrome P450 3A4 (CYP3A4) DMT2FDC MT DME DMT2FDC MA Metabolism DMT2FDC RN Variability in metabolism of imipramine and desipramine using urinary excretion data. J Anal Toxicol. 2014 Jul-Aug;38(6):368-74. DMT2FDC RU https://www.ncbi.nlm.nih.gov/pubmed/?term=24782142 DMT2FDC DI DMT2FDC DMT2FDC DN Desipramine DMT2FDC MI DEGTFWK DMT2FDC MN Mephenytoin 4-hydroxylase (CYP2C19) DMT2FDC MT DME DMT2FDC MA Metabolism DMT2FDC RN Eight inhibitory monoclonal antibodies define the role of individual P-450s in human liver microsomal diazepam, 7-ethoxycoumarin, and imipramine metabolism. Drug Metab Dispos. 1999 Jan;27(1):102-9. DMT2FDC RU https://www.ncbi.nlm.nih.gov/pubmed/?term=9884317 DMT2FDC DI DMT2FDC DMT2FDC DN Desipramine DMT2FDC MI TTAWNKZ DMT2FDC MN Norepinephrine transporter (NET) DMT2FDC MT DTT DMT2FDC MA Inhibitor DMT2FDC RN Augmentation effect of combination therapy of aripiprazole and antidepressants on forced swimming test in mice. Psychopharmacology (Berl). 2009 Sep;206(1):97-107. DMT2FDC RU https://pubmed.ncbi.nlm.nih.gov/19517098 DMT2FDC DI DMT2FDC DMT2FDC DN Desipramine DMT2FDC MI DTT79CX DMT2FDC MN Organic cation transporter 1 (SLC22A1) DMT2FDC MT DTP DMT2FDC MA Substrate DMT2FDC RN Implications of genetic polymorphisms in drug transporters for pharmacotherapy. Cancer Lett. 2006 Mar 8;234(1):4-33. DMT2FDC RU https://doi.org/10.1016/j.canlet.2005.06.051 DMT2FDC DI DMT2FDC DMT2FDC DN Desipramine DMT2FDC MI DTUGYRD DMT2FDC MN P-glycoprotein 1 (ABCB1) DMT2FDC MT DTP DMT2FDC MA Substrate DMT2FDC RN A novel screening strategy to identify ABCB1 substrates and inhibitors. Naunyn Schmiedebergs Arch Pharmacol. 2009 Jan;379(1):11-26. DMT2FDC RU https://doi.org/10.1007/s00210-008-0345-0 DM2BTFN DI DM2BTFN DM2BTFN DN Desirudin Recombinant DM2BTFN MI TT6L509 DM2BTFN MN Coagulation factor IIa (F2) DM2BTFN MT DTT DM2BTFN MA Modulator DM2BTFN RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. DM2BTFN RU https://www.fda.gov/ DMB3ZSK DI DMB3ZSK DMB3ZSK DN Deslanoside DMB3ZSK MI TTWK8D0 DMB3ZSK MN Sodium pump subunit alpha-1 (ATP1A1) DMB3ZSK MT DTT DMB3ZSK MA Binder DMB3ZSK RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMB3ZSK RU https://pubmed.ncbi.nlm.nih.gov/17139284 DM56YN7 DI DM56YN7 DM56YN7 DN Desloratadine DM56YN7 MI DES5XRU DM56YN7 MN Cytochrome P450 2C8 (CYP2C8) DM56YN7 MT DME DM56YN7 MA Metabolism DM56YN7 RN Further characterization of the metabolism of desloratadine and its cytochrome P450 and UDP-glucuronosyltransferase inhibition potential: identification of desloratadine as a relatively selective UGT2B10 inhibitor. Drug Metab Dispos. 2015 Sep;43(9):1294-302. DM56YN7 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=26135009 DM56YN7 DI DM56YN7 DM56YN7 DN Desloratadine DM56YN7 MI TTTIBOJ DM56YN7 MN Histamine H1 receptor (H1R) DM56YN7 MT DTT DM56YN7 MA Antagonist DM56YN7 RN Examining the tolerability of the non-sedating antihistamine desloratadine: a prescription-event monitoring study in England. Drug Saf. 2009;32(2):169-79. DM56YN7 RU https://pubmed.ncbi.nlm.nih.gov/19236123 DM56YN7 DI DM56YN7 DM56YN7 DN Desloratadine DM56YN7 MI DTUGYRD DM56YN7 MN P-glycoprotein 1 (ABCB1) DM56YN7 MT DTP DM56YN7 MA Substrate DM56YN7 RN P-glycoprotein limits the brain penetration of nonsedating but not sedating H1-antagonists. Drug Metab Dispos. 2003 Mar;31(3):312-8. DM56YN7 RU http://www.ncbi.nlm.nih.gov/pubmed/12584158 DM56YN7 DI DM56YN7 DM56YN7 DN Desloratadine DM56YN7 MI DEI8NGH DM56YN7 MN UDP-glucuronosyltransferase 2B10 (UGT2B10) DM56YN7 MT DME DM56YN7 MA Metabolism DM56YN7 RN Further characterization of the metabolism of desloratadine and its cytochrome P450 and UDP-glucuronosyltransferase inhibition potential: identification of desloratadine as a relatively selective UGT2B10 inhibitor. Drug Metab Dispos. 2015 Sep;43(9):1294-302. DM56YN7 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=26135009 DMS3GVE DI DMS3GVE DMS3GVE DN Desmopressin DMS3GVE MI TTSCIUP DMS3GVE MN Oxytocin receptor (OTR) DMS3GVE MT DTT DMS3GVE MA Agonist DMS3GVE RN Design of potent and selective agonists for the human vasopressin V1b receptor based on modifications of [deamino-cys1]arginine vasopressin at position 4. J Med Chem. 2004 Apr 22;47(9):2375-88. DMS3GVE RU https://pubmed.ncbi.nlm.nih.gov/15084136 DMS3GVE DI DMS3GVE DMS3GVE DN Desmopressin DMS3GVE MI TTYCILE DMS3GVE MN Vasopressin receptor (VR) DMS3GVE MT DTT DMS3GVE MA Modulator DMS3GVE RN Vasopressin V2 (SR121463A) and V1a (SR49059) receptor antagonists both inhibit desmopressin vasorelaxing activity. Eur J Pharmacol. 1999 Nov 3;383(3):287-90. DMS3GVE RU https://pubmed.ncbi.nlm.nih.gov/10594321 DMS3GVE DI DMS3GVE DMS3GVE DN Desmopressin DMS3GVE MI TT4TFGN DMS3GVE MN Vasopressin V1a receptor (V1AR) DMS3GVE MT DTT DMS3GVE MA Agonist DMS3GVE RN Design of potent and selective agonists for the human vasopressin V1b receptor based on modifications of [deamino-cys1]arginine vasopressin at position 4. J Med Chem. 2004 Apr 22;47(9):2375-88. DMS3GVE RU https://pubmed.ncbi.nlm.nih.gov/15084136 DMS3GVE DI DMS3GVE DMS3GVE DN Desmopressin DMS3GVE MI TTL9MHW DMS3GVE MN Vasopressin V1b receptor (V1BR) DMS3GVE MT DTT DMS3GVE MA Agonist DMS3GVE RN Design of potent and selective agonists for the human vasopressin V1b receptor based on modifications of [deamino-cys1]arginine vasopressin at position 4. J Med Chem. 2004 Apr 22;47(9):2375-88. DMS3GVE RU https://pubmed.ncbi.nlm.nih.gov/15084136 DMS3GVE DI DMS3GVE DMS3GVE DN Desmopressin DMS3GVE MI TTK8R02 DMS3GVE MN Vasopressin V2 receptor (V2R) DMS3GVE MT DTT DMS3GVE MA Agonist DMS3GVE RN Design of potent and selective agonists for the human vasopressin V1b receptor based on modifications of [deamino-cys1]arginine vasopressin at position 4. J Med Chem. 2004 Apr 22;47(9):2375-88. DMS3GVE RU https://pubmed.ncbi.nlm.nih.gov/15084136 DM27U4Y DI DM27U4Y DM27U4Y DN Desogestrel DM27U4Y MI DE5IED8 DM27U4Y MN Cytochrome P450 2C9 (CYP2C9) DM27U4Y MT DME DM27U4Y MA Metabolism DM27U4Y RN The role of CYP2C in the in vitro bioactivation of the contraceptive steroid desogestrel. J Pharmacol Exp Ther. 1998 Dec;287(3):975-82. DM27U4Y RU https://www.ncbi.nlm.nih.gov/pubmed/?term=9864282 DM27U4Y DI DM27U4Y DM27U4Y DN Desogestrel DM27U4Y MI DE4LYSA DM27U4Y MN Cytochrome P450 3A4 (CYP3A4) DM27U4Y MT DME DM27U4Y MA Metabolism DM27U4Y RN The role of CYP2C and CYP3A in the disposition of 3-keto-desogestrel after administration of desogestrel. Br J Clin Pharmacol. 2005 Jul;60(1):69-75. DM27U4Y RU https://www.ncbi.nlm.nih.gov/pubmed/?term=15963096 DM27U4Y DI DM27U4Y DM27U4Y DN Desogestrel DM27U4Y MI DEGTFWK DM27U4Y MN Mephenytoin 4-hydroxylase (CYP2C19) DM27U4Y MT DME DM27U4Y MA Metabolism DM27U4Y RN The role of CYP2C in the in vitro bioactivation of the contraceptive steroid desogestrel. J Pharmacol Exp Ther. 1998 Dec;287(3):975-82. DM27U4Y RU https://www.ncbi.nlm.nih.gov/pubmed/?term=9864282 DM27U4Y DI DM27U4Y DM27U4Y DN Desogestrel DM27U4Y MI TTUV8G9 DM27U4Y MN Progesterone receptor (PGR) DM27U4Y MT DTT DM27U4Y MA Modulator DM27U4Y RN Preclinical experience with two selective progesterone receptor modulators on breast and endometrium. Steroids. 2000 Oct-Nov;65(10-11):733-40. DM27U4Y RU https://pubmed.ncbi.nlm.nih.gov/11108884 DMTP2NJ DI DMTP2NJ DMTP2NJ DN Desonide DMTP2NJ MI DE4LYSA DMTP2NJ MN Cytochrome P450 3A4 (CYP3A4) DMTP2NJ MT DME DMTP2NJ MA Metabolism DMTP2NJ RN Summary of information on human CYP enzymes: human P450 metabolism data. Drug Metab Rev. 2002 Feb-May;34(1-2):83-448. DMTP2NJ RU https://www.ncbi.nlm.nih.gov/pubmed/?term=11996015 DMTP2NJ DI DMTP2NJ DMTP2NJ DN Desonide DMTP2NJ MI TTP3UTW DMTP2NJ MN Steroid hormone receptor ERR (ESRR) DMTP2NJ MT DTT DMTP2NJ MA Modulator DMTP2NJ RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. DMTP2NJ RU https://www.fda.gov/ DM4PXF6 DI DM4PXF6 DM4PXF6 DN Desoximetasone DM4PXF6 MI TTP3UTW DM4PXF6 MN Steroid hormone receptor ERR (ESRR) DM4PXF6 MT DTT DM4PXF6 MA Modulator DM4PXF6 RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. DM4PXF6 RU https://www.fda.gov/ DMS0AFE DI DMS0AFE DMS0AFE DN Desoxycorticosterone acetate DMS0AFE MI DE4LYSA DMS0AFE MN Cytochrome P450 3A4 (CYP3A4) DMS0AFE MT DME DMS0AFE MA Metabolism DMS0AFE RN Progress in Brain Research. Chapter 11 - Steroidogenic Enzymes in the Brain: Morphological Aspects. 2010, 181:193-207. DMS0AFE RU https://www.sciencedirect.com/science/article/pii/S0079612308810114 DMS0AFE DI DMS0AFE DMS0AFE DN Desoxycorticosterone acetate DMS0AFE MI TT26PHO DMS0AFE MN Mineralocorticoid receptor (MR) DMS0AFE MT DTT DMS0AFE MA Modulator DMS0AFE RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. DMS0AFE RU https://www.fda.gov/ DMSA4B3 DI DMSA4B3 DMSA4B3 DN Desoxycorticosterone pivalate DMSA4B3 MI DE4LYSA DMSA4B3 MN Cytochrome P450 3A4 (CYP3A4) DMSA4B3 MT DME DMSA4B3 MA Metabolism DMSA4B3 RN Progress in Brain Research. Chapter 11 - Steroidogenic Enzymes in the Brain: Morphological Aspects. 2010, 181:193-207. DMSA4B3 RU https://www.sciencedirect.com/science/article/pii/S0079612308810114 DMSA4B3 DI DMSA4B3 DMSA4B3 DN Desoxycorticosterone pivalate DMSA4B3 MI TT26PHO DMSA4B3 MN Mineralocorticoid receptor (MR) DMSA4B3 MT DTT DMSA4B3 MA Binder DMSA4B3 RN Characterization of rat brain aldosterone receptors reveals high affinity for corticosterone. Endocrinology. 1983 Dec;113(6):2043-51. DMSA4B3 RU https://pubmed.ncbi.nlm.nih.gov/6227474 DMEZFXR DI DMEZFXR DMEZFXR DN Desoxyribonuclease DMEZFXR MI TT3C1VN DMEZFXR MN Enzyme unspecific (Enz) DMEZFXR MT DTT DMEZFXR MA Modulator DMEZFXR RN Preparation of the bifunctional enzyme ribonuclease-deoxyribonuclease by cross-linkage. Biochemistry. 1979 Oct 2;18(20):4449-52. DMEZFXR RU https://pubmed.ncbi.nlm.nih.gov/486431 DMJE6KO DI DMJE6KO DMJE6KO DN Desvenalfaxine succinate DMJE6KO MI DECB0K3 DMJE6KO MN Cytochrome P450 2D6 (CYP2D6) DMJE6KO MT DME DMJE6KO MA Metabolism DMJE6KO RN Effect of the CYP2D6*10 genotype on venlafaxine pharmacokinetics in healthy adult volunteers. Br J Clin Pharmacol. 1999 Apr;47(4):450-3. DMJE6KO RU https://www.ncbi.nlm.nih.gov/pubmed/?term=10233212 DMJE6KO DI DMJE6KO DMJE6KO DN Desvenalfaxine succinate DMJE6KO MI DE4LYSA DMJE6KO MN Cytochrome P450 3A4 (CYP3A4) DMJE6KO MT DME DMJE6KO MA Metabolism DMJE6KO RN Desvenlafaxine in the treatment of major depressive disorder. Expert Opin Pharmacother. 2011 Dec;12(18):2923-8. DMJE6KO RU https://www.ncbi.nlm.nih.gov/pubmed/?term=22098230 DMJE6KO DI DMJE6KO DMJE6KO DN Desvenalfaxine succinate DMJE6KO MI TTAWNKZ DMJE6KO MN Norepinephrine transporter (NET) DMJE6KO MT DTT DMJE6KO MA Inhibitor DMJE6KO RN Emerging therapies for fibromyalgia. Expert Opin Emerg Drugs. 2008 Mar;13(1):53-62. DMJE6KO RU https://pubmed.ncbi.nlm.nih.gov/18321148 DMHD4PE DI DMHD4PE DMHD4PE DN Desvenlafaxine DMHD4PE MI TT3ROYC DMHD4PE MN Serotonin transporter (SERT) DMHD4PE MT DTT DMHD4PE MA Modulator DMHD4PE RN 2008 FDA drug approvals. Nat Rev Drug Discov. 2009 Feb;8(2):93-6. DMHD4PE RU https://pubmed.ncbi.nlm.nih.gov/19180096 DMUPFLI DI DMUPFLI DMUPFLI DN Deutetrabenazine DMUPFLI MI DEJGDUW DMUPFLI MN Cytochrome P450 1A2 (CYP1A2) DMUPFLI MT DME DMUPFLI MA Metabolism DMUPFLI RN FDA Label of Deutetrabenazine. The 2020 official website of the U.S. Food and Drug Administration. DMUPFLI RU https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/208082s000lbl.pdf DMUPFLI DI DMUPFLI DMUPFLI DN Deutetrabenazine DMUPFLI MI DECB0K3 DMUPFLI MN Cytochrome P450 2D6 (CYP2D6) DMUPFLI MT DME DMUPFLI MA Metabolism DMUPFLI RN FDA Label of Deutetrabenazine. The 2020 official website of the U.S. Food and Drug Administration. DMUPFLI RU https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/208082s000lbl.pdf DMUPFLI DI DMUPFLI DMUPFLI DN Deutetrabenazine DMUPFLI MI TTNZRI3 DMUPFLI MN Synaptic vesicle amine transporter (SLC18A2) DMUPFLI MT DTT DMUPFLI MA Modulator DMUPFLI RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. DMUPFLI RU https://www.fda.gov/ DMMWZET DI DMMWZET DMMWZET DN Dexamethasone DMMWZET MI DETHCPD DMMWZET MN Carboxylesterase 2 (CES2) DMMWZET MT DME DMMWZET MA Metabolism DMMWZET RN In vitro metabolism of dexamethasone cipecilate, a novel synthetic corticosteroid, in human liver and nasal mucosa. Xenobiotica. 2011 Oct;41(10):874-84. DMMWZET RU https://www.ncbi.nlm.nih.gov/pubmed/?term=21657966 DMMWZET DI DMMWZET DMMWZET DN Dexamethasone DMMWZET MI DEDH7FP DMMWZET MN Corticosteroid 11-beta-dehydrogenase 2 (HSD11B2) DMMWZET MT DME DMMWZET MA Metabolism DMMWZET RN Metabolism of synthetic steroids by the human placenta. Placenta. 2007 Jan;28(1):39-46. DMMWZET RU https://www.ncbi.nlm.nih.gov/pubmed/?term=16549198 DMMWZET DI DMMWZET DMMWZET DN Dexamethasone DMMWZET MI DE4LYSA DMMWZET MN Cytochrome P450 3A4 (CYP3A4) DMMWZET MT DME DMMWZET MA Metabolism DMMWZET RN Identification of drugs inhibiting the in vitro metabolism of tacrolimus by human liver microsomes. Br J Clin Pharmacol. 1996 Mar;41(3):187-90. DMMWZET RU https://www.ncbi.nlm.nih.gov/pubmed/?term=8866917 DMMWZET DI DMMWZET DMMWZET DN Dexamethasone DMMWZET MI DEIBDNY DMMWZET MN Cytochrome P450 3A5 (CYP3A5) DMMWZET MT DME DMMWZET MA Metabolism DMMWZET RN Regulation of CYP3A5 by glucocorticoids and cigarette smoke in human lung-derived cells. J Pharmacol Exp Ther. 2003 Feb;304(2):745-52. DMMWZET RU https://www.ncbi.nlm.nih.gov/pubmed/?term=12538830 DMMWZET DI DMMWZET DMMWZET DN Dexamethasone DMMWZET MI DERD86B DMMWZET MN Cytochrome P450 3A7 (CYP3A7) DMMWZET MT DME DMMWZET MA Metabolism DMMWZET RN Cytotoxicity of chloroacetanilide herbicide alachlor in HepG2 cells independent of CYP3A4 and CYP3A7. Food Chem Toxicol. 2007 May;45(5):871-7. DMMWZET RU https://www.ncbi.nlm.nih.gov/pubmed/?term=17207564 DMMWZET DI DMMWZET DMMWZET DN Dexamethasone DMMWZET MI TTYRL6O DMMWZET MN Glucocorticoid receptor (NR3C1) DMMWZET MT DTT DMMWZET MA Agonist DMMWZET RN Interaction between the glucocorticoid and erythropoietin receptors in human erythroid cells. Exp Hematol. 2009 May;37(5):559-72. DMMWZET RU https://pubmed.ncbi.nlm.nih.gov/19375647 DMMWZET DI DMMWZET DMMWZET DN Dexamethasone DMMWZET MI DT9G7XN DMMWZET MN Peptide transporter 1 (SLC15A1) DMMWZET MT DTP DMMWZET MA Substrate DMMWZET RN Peptide transporter substrate identification during permeability screening in drug discovery: comparison of transfected MDCK-hPepT1 cells to Caco-2 cells. Arch Pharm Res. 2007 Apr;30(4):507-18. DMMWZET RU https://doi.org/10.1007/BF02980227 DMMWZET DI DMMWZET DMMWZET DN Dexamethasone DMMWZET MI DTUGYRD DMMWZET MN P-glycoprotein 1 (ABCB1) DMMWZET MT DTP DMMWZET MA Substrate DMMWZET RN Modulation of drug-stimulated ATPase activity of human MDR1/P-glycoprotein by cholesterol. Biochem J. 2007 Jan 15;401(2):597-605. DMMWZET RU http://www.ncbi.nlm.nih.gov/pubmed/17029589 DMIG8DW DI DMIG8DW DMIG8DW DN Dexamethasone sodium phosphate DMIG8DW MI DE4LYSA DMIG8DW MN Cytochrome P450 3A4 (CYP3A4) DMIG8DW MT DME DMIG8DW MA Metabolism DMIG8DW RN Identification of drugs inhibiting the in vitro metabolism of tacrolimus by human liver microsomes. Br J Clin Pharmacol. 1996 Mar;41(3):187-90. DMIG8DW RU https://www.ncbi.nlm.nih.gov/pubmed/?term=8866917 DMIG8DW DI DMIG8DW DMIG8DW DN Dexamethasone sodium phosphate DMIG8DW MI TTYRL6O DMIG8DW MN Glucocorticoid receptor (NR3C1) DMIG8DW MT DTT DMIG8DW MA Agonist DMIG8DW RN Dexamethasone rapidly increases GABA release in the dorsal motor nucleus of the vagus via retrograde messenger-mediated enhancement of TRPV1 activity. PLoS One. 2013 Jul 30;8(7):e70505. DMIG8DW RU https://pubmed.ncbi.nlm.nih.gov/23936221 DMKVWGE DI DMKVWGE DMKVWGE DN Dexbrompheniramine DMKVWGE MI TTTIBOJ DMKVWGE MN Histamine H1 receptor (H1R) DMKVWGE MT DTT DMKVWGE MA Antagonist DMKVWGE RN H2 histaminergic control of inhibition of eating induced by intragastric NaCl in rats. Physiol Behav. 1998 Aug;65(1):105-13. DMKVWGE RU https://pubmed.ncbi.nlm.nih.gov/9811372 DMA8DPN DI DMA8DPN DMA8DPN DN Dexchlorpheniramine maleate DMA8DPN MI DECB0K3 DMA8DPN MN Cytochrome P450 2D6 (CYP2D6) DMA8DPN MT DME DMA8DPN MA Metabolism DMA8DPN RN The roles of CYP2D6 and stereoselectivity in the clinical pharmacokinetics of chlorpheniramine. Br J Clin Pharmacol. 2002 May;53(5):519-25. DMA8DPN RU https://www.ncbi.nlm.nih.gov/pubmed/?term=11994058 DMA8DPN DI DMA8DPN DMA8DPN DN Dexchlorpheniramine maleate DMA8DPN MI TTTIBOJ DMA8DPN MN Histamine H1 receptor (H1R) DMA8DPN MT DTT DMA8DPN MA Modulator DMA8DPN RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. DMA8DPN RU https://www.fda.gov/ DMFYBD0 DI DMFYBD0 DMFYBD0 DN Dexibuprofen DMFYBD0 MI DEGKWJB DMFYBD0 MN Alpha-methylacyl-CoA racemase (AMACR) DMFYBD0 MT DME DMFYBD0 MA Metabolism DMFYBD0 RN Alpha-Methylacyl-CoA racemase (AMACR): metabolic enzyme, drug metabolizer and cancer marker P504S. Prog Lipid Res. 2013 Apr;52(2):220-30. DMFYBD0 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=23376124 DMFYBD0 DI DMFYBD0 DMFYBD0 DN Dexibuprofen DMFYBD0 MI DES5XRU DMFYBD0 MN Cytochrome P450 2C8 (CYP2C8) DMFYBD0 MT DME DMFYBD0 MA Metabolism DMFYBD0 RN Influence of CYP2C8 polymorphisms on the hydroxylation metabolism of paclitaxel, repaglinide and ibuprofen enantiomers in vitro. Biopharm Drug Dispos. 2013 Jul;34(5):278-87. DMFYBD0 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=23536207 DMFYBD0 DI DMFYBD0 DMFYBD0 DN Dexibuprofen DMFYBD0 MI DE5IED8 DMFYBD0 MN Cytochrome P450 2C9 (CYP2C9) DMFYBD0 MT DME DMFYBD0 MA Metabolism DMFYBD0 RN New insights into the structural features and functional relevance of human cytochrome P450 2C9. Part I. Curr Drug Metab. 2009 Dec;10(10):1075-126. DMFYBD0 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=20167001 DMFYBD0 DI DMFYBD0 DMFYBD0 DN Dexibuprofen DMFYBD0 MI DEGTFWK DMFYBD0 MN Mephenytoin 4-hydroxylase (CYP2C19) DMFYBD0 MT DME DMFYBD0 MA Metabolism DMFYBD0 RN PharmGKB summary: ibuprofen pathways. Pharmacogenet Genomics. 2015 Feb;25(2):96-106. DMFYBD0 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=25502615 DMFYBD0 DI DMFYBD0 DMFYBD0 DN Dexibuprofen DMFYBD0 MI TTK0943 DMFYBD0 MN Prostaglandin G/H synthase (COX) DMFYBD0 MT DTT DMFYBD0 MA Modulator DMFYBD0 RN Comparison of the efficacy and tolerability of dexibuprofen and celecoxib in the treatment of osteoarthritis of the hip. Int J Clin Pharmacol Ther. 2003 Apr;41(4):153-64. DMFYBD0 RU https://pubmed.ncbi.nlm.nih.gov/12708604 DMFYBD0 DI DMFYBD0 DMFYBD0 DN Dexibuprofen DMFYBD0 MI DEYGVN4 DMFYBD0 MN UDP-glucuronosyltransferase 1A1 (UGT1A1) DMFYBD0 MT DME DMFYBD0 MA Metabolism DMFYBD0 RN Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. DMFYBD0 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=19515014 DMFYBD0 DI DMFYBD0 DMFYBD0 DN Dexibuprofen DMFYBD0 MI DEF2WXN DMFYBD0 MN UDP-glucuronosyltransferase 1A3 (UGT1A3) DMFYBD0 MT DME DMFYBD0 MA Metabolism DMFYBD0 RN Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. DMFYBD0 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=19515014 DMFYBD0 DI DMFYBD0 DMFYBD0 DN Dexibuprofen DMFYBD0 MI DE85D2P DMFYBD0 MN UDP-glucuronosyltransferase 1A9 (UGT1A9) DMFYBD0 MT DME DMFYBD0 MA Metabolism DMFYBD0 RN Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. DMFYBD0 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=19515014 DMFYBD0 DI DMFYBD0 DMFYBD0 DN Dexibuprofen DMFYBD0 MI DEB3CV1 DMFYBD0 MN UDP-glucuronosyltransferase 2B7 (UGT2B7) DMFYBD0 MT DME DMFYBD0 MA Metabolism DMFYBD0 RN Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. DMFYBD0 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=19515014 DM1DBV5 DI DM1DBV5 DM1DBV5 DN Dexlansoprazole DM1DBV5 MI DE4LYSA DM1DBV5 MN Cytochrome P450 3A4 (CYP3A4) DM1DBV5 MT DME DM1DBV5 MA Metabolism DM1DBV5 RN Absorption, distribution, metabolism and excretion of [14C]dexlansoprazole in healthy male subjects. Clin Drug Investig. 2012 May 1;32(5):319-32. DM1DBV5 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=22455762 DM1DBV5 DI DM1DBV5 DM1DBV5 DN Dexlansoprazole DM1DBV5 MI TTLOKXP DM1DBV5 MN Gastric H(+)/K(+) ATPase (Proton pump) DM1DBV5 MT DTT DM1DBV5 MA Modulator DM1DBV5 RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. DM1DBV5 RU https://www.fda.gov/ DM1DBV5 DI DM1DBV5 DM1DBV5 DN Dexlansoprazole DM1DBV5 MI TTF1QVM DM1DBV5 MN Gastric H(+)/K(+) ATPase alpha (ATP4A) DM1DBV5 MT DTT DM1DBV5 MA Inhibitor DM1DBV5 RN Clinical pipeline report, company report or official report of Takeda (2009). DM1DBV5 RU http://www.takeda.com/pdf/usr/default/10_1_34992_2.pdf DM1DBV5 DI DM1DBV5 DM1DBV5 DN Dexlansoprazole DM1DBV5 MI DEGTFWK DM1DBV5 MN Mephenytoin 4-hydroxylase (CYP2C19) DM1DBV5 MT DME DM1DBV5 MA Metabolism DM1DBV5 RN Pharmacological and safety profile of dexlansoprazole: a new proton pump inhibitor - implications for treatment of gastroesophageal reflux disease in the Asia Pacific region. J Neurogastroenterol Motil. 2016 Jul 30;22(3):355-66. DM1DBV5 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=26932927 DM1DBV5 DI DM1DBV5 DM1DBV5 DN Dexlansoprazole DM1DBV5 MI DTUGYRD DM1DBV5 MN P-glycoprotein 1 (ABCB1) DM1DBV5 MT DTP DM1DBV5 MA Substrate DM1DBV5 RN A novel screening strategy to identify ABCB1 substrates and inhibitors. Naunyn Schmiedebergs Arch Pharmacol. 2009 Jan;379(1):11-26. DM1DBV5 RU https://doi.org/10.1007/s00210-008-0345-0 DM93L4X DI DM93L4X DM93L4X DN Dexmedetomidine DM93L4X MI TTQ8AFT DM93L4X MN Adrenergic receptor Alpha-2 (ADRA2) DM93L4X MT DTT DM93L4X MA Agonist DM93L4X RN Dexmedetomidine in intensive care unit: a study of hemodynamic changes. Middle East J Anesthesiol. 2002 Oct;16(6):587-95. DM93L4X RU https://pubmed.ncbi.nlm.nih.gov/12503262 DM93L4X DI DM93L4X DM93L4X DN Dexmedetomidine DM93L4X MI DEJGDUW DM93L4X MN Cytochrome P450 1A2 (CYP1A2) DM93L4X MT DME DM93L4X MA Metabolism DM93L4X RN Predominant role of peripheral catecholamines in the stress-induced modulation of CYP1A2 inducibility by benzo(alpha)pyrene. Basic Clin Pharmacol Toxicol. 2008 Jan;102(1):35-44. DM93L4X RU https://www.ncbi.nlm.nih.gov/pubmed/?term=17973897 DM93L4X DI DM93L4X DM93L4X DN Dexmedetomidine DM93L4X MI DEJVYAZ DM93L4X MN Cytochrome P450 2A6 (CYP2A6) DM93L4X MT DME DM93L4X MA Metabolism DM93L4X RN Impact of CYP2A6 gene polymorphism on the pharmacokinetics of dexmedetomidine for premedication. Expert Rev Clin Pharmacol. 2018 Sep;11(9):917-922. DM93L4X RU https://www.ncbi.nlm.nih.gov/pubmed/?term=30092666 DM93L4X DI DM93L4X DM93L4X DN Dexmedetomidine DM93L4X MI DEVDYN7 DM93L4X MN Cytochrome P450 2E1 (CYP2E1) DM93L4X MT DME DM93L4X MA Metabolism DM93L4X RN Metabolic stability and determination of cytochrome P450 isoenzymes' contribution to the metabolism of medetomidine in dog liver microsomes. Biomed Chromatogr. 2010 Aug;24(8):868-77. DM93L4X RU https://www.ncbi.nlm.nih.gov/pubmed/?term=20020418 DMUQE2A DI DMUQE2A DMUQE2A DN Dexmethylphenidate DMUQE2A MI DEB30C5 DMUQE2A MN Carboxylesterase 1 (CES1) DMUQE2A MT DME DMUQE2A MA Metabolism DMUQE2A RN Dexmethylphenidate hydrochloride in the treatment of attention deficit hyperactivity disorder. Neuropsychiatr Dis Treat. 2006 Dec;2(4):467-73. DMUQE2A RU https://www.ncbi.nlm.nih.gov/pubmed/?term=19412495 DM8WBAH DI DM8WBAH DM8WBAH DN Dexmethylphenidate hydrochloride DM8WBAH MI TTVBI8W DM8WBAH MN Dopamine transporter (DAT) DM8WBAH MT DTT DM8WBAH MA Inhibitor DM8WBAH RN Synthesis and pharmacology of site-specific cocaine abuse treatment agents: restricted rotation analogues of methylphenidate. J Med Chem. 2007 May 31;50(11):2718-31. DM8WBAH RU https://pubmed.ncbi.nlm.nih.gov/17489581 DMD7X1O DI DMD7X1O DMD7X1O DN Dexrazoxane DMD7X1O MI DE0EUXB DMD7X1O MN Dihydropyrimidinase-related protein 1 (DRP1) DMD7X1O MT DME DMD7X1O MA Metabolism DMD7X1O RN Metabolism of the cardioprotective drug dexrazoxane and one of its metabolites by isolated rat myocytes, hepatocytes, and blood. Drug Metab Dispos. 2005 Jun;33(6):719-25. DMD7X1O RU https://www.ncbi.nlm.nih.gov/pubmed/?term=15764716 DMD7X1O DI DMD7X1O DMD7X1O DN Dexrazoxane DMD7X1O MI TT0IHXV DMD7X1O MN DNA topoisomerase II (TOP2) DMD7X1O MT DTT DMD7X1O MA Modulator DMD7X1O RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. DMD7X1O RU https://www.fda.gov/ DMD7X1O DI DMD7X1O DMD7X1O DN Dexrazoxane DMD7X1O MI TT4NVEM DMD7X1O MN DNA topoisomerase II beta (TOP2B) DMD7X1O MT DTT DMD7X1O MA Inhibitor DMD7X1O RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMD7X1O RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMMIHVP DI DMMIHVP DMMIHVP DN Dextroamphetamine DMMIHVP MI DECB0K3 DMMIHVP MN Cytochrome P450 2D6 (CYP2D6) DMMIHVP MT DME DMMIHVP MA Metabolism DMMIHVP RN Involvement of CYP2D6 in the in vitro metabolism of amphetamine, two N-alkylamphetamines and their 4-methoxylated derivatives. Xenobiotica. 1999 Jul;29(7):719-32. DMMIHVP RU https://www.ncbi.nlm.nih.gov/pubmed/?term=10456690 DMMIHVP DI DMMIHVP DMMIHVP DN Dextroamphetamine DMMIHVP MI TTIU98M DMMIHVP MN Trace amine-associated receptor-1 (TAAR1) DMMIHVP MT DTT DMMIHVP MA Modulator DMMIHVP RN Methamphetamine and HIV-1-induced neurotoxicity: role of trace amine associated receptor 1 cAMP signaling in astrocytes. Neuropharmacology. 2014 Oct;85:499-507. DMMIHVP RU https://pubmed.ncbi.nlm.nih.gov/24950453 DMUDJZM DI DMUDJZM DMUDJZM DN Dextromethorphan DMUDJZM MI DEKP5HX DMUDJZM MN Cholesterol 24-hydroxylase (CYP46A1) DMUDJZM MT DME DMUDJZM MA Metabolism DMUDJZM RN Broad substrate specificity of human cytochrome P450 46A1 which initiates cholesterol degradation in the brain. Biochemistry. 2003 Dec 9;42(48):14284-92. DMUDJZM RU https://www.ncbi.nlm.nih.gov/pubmed/?term=14640697 DMUDJZM DI DMUDJZM DMUDJZM DN Dextromethorphan DMUDJZM MI DE4OGUF DMUDJZM MN Cytochrome P450 102A1 (cyp102) DMUDJZM MT DME DMUDJZM MA Metabolism DMUDJZM RN The bacterial P450 BM3: a prototype for a biocatalyst with human P450 activities. Trends Biotechnol. 2007 Jul;25(7):289-98. DMUDJZM RU https://pubmed.ncbi.nlm.nih.gov/17532492 DMUDJZM DI DMUDJZM DMUDJZM DN Dextromethorphan DMUDJZM MI DE6CQ0I DMUDJZM MN Cytochrome P450 130A1 (cyp130) DMUDJZM MT DME DMUDJZM MA Metabolism DMUDJZM RN Function, essentiality, and expression of cytochrome P450 enzymes and their cognate redox partners in Mycobacterium tuberculosis: are they drug targets? Appl Microbiol Biotechnol. 2019 May;103(9):3597-3614. DMUDJZM RU https://pubmed.ncbi.nlm.nih.gov/30810776 DMUDJZM DI DMUDJZM DMUDJZM DN Dextromethorphan DMUDJZM MI DEPKLMQ DMUDJZM MN Cytochrome P450 2B6 (CYP2B6) DMUDJZM MT DME DMUDJZM MA Metabolism DMUDJZM RN Enzymes in addition to CYP3A4 and 3A5 mediate N-demethylation of dextromethorphan in human liver microsomes. Biopharm Drug Dispos. 1999 Oct;20(7):341-6. DMUDJZM RU https://www.ncbi.nlm.nih.gov/pubmed/?term=10760842 DMUDJZM DI DMUDJZM DMUDJZM DN Dextromethorphan DMUDJZM MI DE5IED8 DMUDJZM MN Cytochrome P450 2C9 (CYP2C9) DMUDJZM MT DME DMUDJZM MA Metabolism DMUDJZM RN Multiple human cytochromes contribute to biotransformation of dextromethorphan in-vitro: role of CYP2C9, CYP2C19, CYP2D6, and CYP3A. J Pharm Pharmacol. 1998 Sep;50(9):997-1004. DMUDJZM RU https://www.ncbi.nlm.nih.gov/pubmed/?term=9811160 DMUDJZM DI DMUDJZM DMUDJZM DN Dextromethorphan DMUDJZM MI DECB0K3 DMUDJZM MN Cytochrome P450 2D6 (CYP2D6) DMUDJZM MT DME DMUDJZM MA Metabolism DMUDJZM RN Polymorphism of human cytochrome P450 2D6 and its clinical significance: Part I. Clin Pharmacokinet. 2009;48(11):689-723. DMUDJZM RU https://www.ncbi.nlm.nih.gov/pubmed/?term=19817501 DMUDJZM DI DMUDJZM DMUDJZM DN Dextromethorphan DMUDJZM MI DE4LYSA DMUDJZM MN Cytochrome P450 3A4 (CYP3A4) DMUDJZM MT DME DMUDJZM MA Metabolism DMUDJZM RN Comparative contribution to dextromethorphan metabolism by cytochrome P450 isoforms in vitro: can dextromethorphan be used as a dual probe for both CTP2D6 and CYP3A activities? Drug Metab Dispos. 2001 Nov;29(11):1514-20. DMUDJZM RU https://www.ncbi.nlm.nih.gov/pubmed/?term=11602530 DMUDJZM DI DMUDJZM DMUDJZM DN Dextromethorphan DMUDJZM MI DEIBDNY DMUDJZM MN Cytochrome P450 3A5 (CYP3A5) DMUDJZM MT DME DMUDJZM MA Metabolism DMUDJZM RN Summary of information on human CYP enzymes: human P450 metabolism data. Drug Metab Rev. 2002 Feb-May;34(1-2):83-448. DMUDJZM RU https://www.ncbi.nlm.nih.gov/pubmed/?term=11996015 DMUDJZM DI DMUDJZM DMUDJZM DN Dextromethorphan DMUDJZM MI DERD86B DMUDJZM MN Cytochrome P450 3A7 (CYP3A7) DMUDJZM MT DME DMUDJZM MA Metabolism DMUDJZM RN Characterization of dextromethorphan N-demethylation by human liver microsomes. Contribution of the cytochrome P450 3A (CYP3A) subfamily. Biochem Pharmacol. 1994 Jul 5;48(1):173-82. DMUDJZM RU https://www.ncbi.nlm.nih.gov/pubmed/?term=8043020 DMUDJZM DI DMUDJZM DMUDJZM DN Dextromethorphan DMUDJZM MI DEGTFWK DMUDJZM MN Mephenytoin 4-hydroxylase (CYP2C19) DMUDJZM MT DME DMUDJZM MA Metabolism DMUDJZM RN Multiple human cytochromes contribute to biotransformation of dextromethorphan in-vitro: role of CYP2C9, CYP2C19, CYP2D6, and CYP3A. J Pharm Pharmacol. 1998 Sep;50(9):997-1004. DMUDJZM RU https://www.ncbi.nlm.nih.gov/pubmed/?term=9811160 DMUDJZM DI DMUDJZM DMUDJZM DN Dextromethorphan DMUDJZM MI TT5TPI6 DMUDJZM MN Opioid receptor sigma 1 (OPRS1) DMUDJZM MT DTT DMUDJZM MA Agonist DMUDJZM RN Dextromethorphan/quinidine: AVP 923, dextromethorphan/cytochrome P450-2D6 inhibitor, quinidine/dextromethorphan. Drugs R D. 2005;6(3):174-7. DMUDJZM RU https://pubmed.ncbi.nlm.nih.gov/15869321 DMEHCY5 DI DMEHCY5 DMEHCY5 DN Dextromethorphan polistirex DMEHCY5 MI TT5TPI6 DMEHCY5 MN Opioid receptor sigma 1 (OPRS1) DMEHCY5 MT DTT DMEHCY5 MA Modulator DMEHCY5 RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. DMEHCY5 RU https://www.fda.gov/ DMEHCY5 DI DMEHCY5 DMEHCY5 DN Dextromethorphan polistirex DMEHCY5 MI TT3ROYC DMEHCY5 MN Serotonin transporter (SERT) DMEHCY5 MT DTT DMEHCY5 MA Modulator DMEHCY5 RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. DMEHCY5 RU https://www.fda.gov/ DM23HCX DI DM23HCX DM23HCX DN Dextropropoxyphene DM23HCX MI DECB0K3 DM23HCX MN Cytochrome P450 2D6 (CYP2D6) DM23HCX MT DME DM23HCX MA Metabolism DM23HCX RN Different effects of inhibitors on the O- and N-demethylation of codeine in human liver microsomes. Eur J Clin Pharmacol. 1997;52(1):41-7. DM23HCX RU https://www.ncbi.nlm.nih.gov/pubmed/?term=9143866 DM23HCX DI DM23HCX DM23HCX DN Dextropropoxyphene DM23HCX MI DE4LYSA DM23HCX MN Cytochrome P450 3A4 (CYP3A4) DM23HCX MT DME DM23HCX MA Metabolism DM23HCX RN CYP3A4 mediates dextropropoxyphene N-demethylation to nordextropropoxyphene: human in vitro and in vivo studies and lack of CYP2D6 involvement. Xenobiotica. 2004 Oct;34(10):875-87. DM23HCX RU https://www.ncbi.nlm.nih.gov/pubmed/?term=15764408 DM23HCX DI DM23HCX DM23HCX DN Dextropropoxyphene DM23HCX MI TTN4QDT DM23HCX MN Opioid receptor (OPR) DM23HCX MT DTT DM23HCX MA Agonist DM23HCX RN Retrospective diagnosis of an adverse drug reaction in a breastfed neonate: liquid chromatography-tandem mass spectrometry quantification of dextropropoxyphene and norpropoxyphene in newborn and maternal hair. J Anal Toxicol. 2008 Nov-Dec;39(9):787-9. DM23HCX RU https://pubmed.ncbi.nlm.nih.gov/19021937 DMBVEC7 DI DMBVEC7 DMBVEC7 DN Dextrothyroxine Sodium DMBVEC7 MI TTTSEPU DMBVEC7 MN Thyroid hormone receptor alpha (THRA) DMBVEC7 MT DTT DMBVEC7 MA Modulator DMBVEC7 RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. DMBVEC7 RU https://www.fda.gov/ DMBVEC7 DI DMBVEC7 DMBVEC7 DN Dextrothyroxine Sodium DMBVEC7 MI TTGER3L DMBVEC7 MN Thyroid hormone receptor beta (THRB) DMBVEC7 MT DTT DMBVEC7 MA Modulator DMBVEC7 RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. DMBVEC7 RU https://www.fda.gov/ DMJDB0Y DI DMJDB0Y DMJDB0Y DN Dezocine DMJDB0Y MI TTQW87Y DMJDB0Y MN Opioid receptor kappa (OPRK1) DMJDB0Y MT DTT DMJDB0Y MA Antagonist DMJDB0Y RN Pharmacological profiles of opioid ligands at kappa opioid receptors. BMC Pharmacol. 2006 Jan 25;6:3. DMJDB0Y RU https://pubmed.ncbi.nlm.nih.gov/16433932 DMU3FGB DI DMU3FGB DMU3FGB DN Dhaq diacetate DMU3FGB MI TT0IHXV DMU3FGB MN DNA topoisomerase II (TOP2) DMU3FGB MT DTT DMU3FGB MA Inhibitor DMU3FGB RN The hypoxia-activated ProDrug AQ4N penetrates deeply in tumor tissues and complements the limited distribution of mitoxantrone. Cancer Res. 2009 Feb 1;69(3):940-7. DMU3FGB RU https://pubmed.ncbi.nlm.nih.gov/19176397 DM08E9O DI DM08E9O DM08E9O DN Diazepam DM08E9O MI DEJGDUW DM08E9O MN Cytochrome P450 1A2 (CYP1A2) DM08E9O MT DME DM08E9O MA Metabolism DM08E9O RN In vitro metabolism of zolmitriptan in rat cytochromes induced with beta-naphthoflavone and the interaction between six drugs and zolmitriptan. Chem Biol Interact. 2003 Dec 15;146(3):263-72. DM08E9O RU https://www.ncbi.nlm.nih.gov/pubmed/?term=14642738 DM08E9O DI DM08E9O DM08E9O DN Diazepam DM08E9O MI DEPKLMQ DM08E9O MN Cytochrome P450 2B6 (CYP2B6) DM08E9O MT DME DM08E9O MA Metabolism DM08E9O RN Inhibitory monoclonal antibody to human cytochrome P450 2B6. Biochem Pharmacol. 1998 May 15;55(10):1633-40. DM08E9O RU https://www.ncbi.nlm.nih.gov/pubmed/?term=9633999 DM08E9O DI DM08E9O DM08E9O DN Diazepam DM08E9O MI DEZMWRE DM08E9O MN Cytochrome P450 2C18 (CYP2C18) DM08E9O MT DME DM08E9O MA Metabolism DM08E9O RN Targeted antipeptide antibodies to cytochrome P450 2C18 based on epitope mapping of an inhibitory monoclonal antibody to P450 2C51. Arch Biochem Biophys. 1997 Feb 15;338(2):157-64. DM08E9O RU https://www.ncbi.nlm.nih.gov/pubmed/?term=9028867 DM08E9O DI DM08E9O DM08E9O DN Diazepam DM08E9O MI DES5XRU DM08E9O MN Cytochrome P450 2C8 (CYP2C8) DM08E9O MT DME DM08E9O MA Metabolism DM08E9O RN Use of inhibitory monoclonal antibodies to assess the contribution of cytochromes P450 to human drug metabolism. Eur J Pharmacol. 2000 Apr 14;394(2-3):199-209. DM08E9O RU https://www.ncbi.nlm.nih.gov/pubmed/?term=10771285 DM08E9O DI DM08E9O DM08E9O DN Diazepam DM08E9O MI DE5IED8 DM08E9O MN Cytochrome P450 2C9 (CYP2C9) DM08E9O MT DME DM08E9O MA Metabolism DM08E9O RN Phenytoin-diazepam interaction. Ann Pharmacother. 2003 May;37(5):659-63. DM08E9O RU https://www.ncbi.nlm.nih.gov/pubmed/?term=12708941 DM08E9O DI DM08E9O DM08E9O DN Diazepam DM08E9O MI DE4LYSA DM08E9O MN Cytochrome P450 3A4 (CYP3A4) DM08E9O MT DME DM08E9O MA Metabolism DM08E9O RN Comparative study of the metabolism of drug substrates by human cytochrome P450 3A4 expressed in bacterial, yeast and human lymphoblastoid cells. Xenobiotica. 2002 Nov;32(11):937-47. DM08E9O RU https://www.ncbi.nlm.nih.gov/pubmed/?term=12487724 DM08E9O DI DM08E9O DM08E9O DN Diazepam DM08E9O MI DEIBDNY DM08E9O MN Cytochrome P450 3A5 (CYP3A5) DM08E9O MT DME DM08E9O MA Metabolism DM08E9O RN Eight inhibitory monoclonal antibodies define the role of individual P-450s in human liver microsomal diazepam, 7-ethoxycoumarin, and imipramine metabolism. Drug Metab Dispos. 1999 Jan;27(1):102-9. DM08E9O RU https://www.ncbi.nlm.nih.gov/pubmed/?term=9884317 DM08E9O DI DM08E9O DM08E9O DN Diazepam DM08E9O MI DERD86B DM08E9O MN Cytochrome P450 3A7 (CYP3A7) DM08E9O MT DME DM08E9O MA Metabolism DM08E9O RN Drug Interactions Flockhart Table DM08E9O RU https://drug-interactions.medicine.iu.edu/Main-Table.aspx DM08E9O DI DM08E9O DM08E9O DN Diazepam DM08E9O MI DEGTFWK DM08E9O MN Mephenytoin 4-hydroxylase (CYP2C19) DM08E9O MT DME DM08E9O MA Metabolism DM08E9O RN Summary of information on human CYP enzymes: human P450 metabolism data. Drug Metab Rev. 2002 Feb-May;34(1-2):83-448. DM08E9O RU https://www.ncbi.nlm.nih.gov/pubmed/?term=11996015 DM08E9O DI DM08E9O DM08E9O DN Diazepam DM08E9O MI DTUGYRD DM08E9O MN P-glycoprotein 1 (ABCB1) DM08E9O MT DTP DM08E9O MA Substrate DM08E9O RN Comparative studies on in vitro methods for evaluating in vivo function of MDR1 P-glycoprotein. Pharm Res. 2001 Dec;18(12):1660-8. DM08E9O RU http://www.ncbi.nlm.nih.gov/pubmed/11785684 DM08E9O DI DM08E9O DM08E9O DN Diazepam DM08E9O MI DE073H6 DM08E9O MN Prostaglandin G/H synthase 1 (COX-1) DM08E9O MT DME DM08E9O MA Metabolism DM08E9O RN Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. DM08E9O RU https://www.ncbi.nlm.nih.gov/pubmed/?term=19515014 DM08E9O DI DM08E9O DM08E9O DN Diazepam DM08E9O MI TTPTXIN DM08E9O MN Translocator protein (TSPO) DM08E9O MT DTT DM08E9O MA Agonist DM08E9O RN Translocator protein (18 kDa) mediates the pro-growth effects of diazepam on Ehrlich tumor cells in vivo. Eur J Pharmacol. 2010 Jan 25;626(2-3):131-8. DM08E9O RU https://pubmed.ncbi.nlm.nih.gov/19782064 DML1538 DI DML1538 DML1538 DN Diazoxide DML1538 MI TT1VOHK DML1538 MN Potassium channel unspecific (KC) DML1538 MT DTT DML1538 MA Modulator DML1538 RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. DML1538 RU https://www.fda.gov/ DMF9G7L DI DMF9G7L DMF9G7L DN Dibucaine DMF9G7L MI TTZOVE0 DMF9G7L MN Voltage-gated sodium channel alpha Nav1.5 (SCN5A) DMF9G7L MT DTT DMF9G7L MA Blocker DMF9G7L RN Halothane attenuates the cerebroprotective action of several Na+ and Ca2+ channel blockers via reversal of their ion channel blockade. Eur J Pharmacol. 2002 Oct 4;452(2):175-81. DMF9G7L RU https://pubmed.ncbi.nlm.nih.gov/12354567 DMH7IDQ DI DMH7IDQ DMH7IDQ DN Dichlorphenamide DMH7IDQ MI TTHQPL7 DMH7IDQ MN Carbonic anhydrase I (CA-I) DMH7IDQ MT DTT DMH7IDQ MA Modulator DMH7IDQ RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. DMH7IDQ RU https://www.fda.gov/ DMH7IDQ DI DMH7IDQ DMH7IDQ DN Dichlorphenamide DMH7IDQ MI TTANPDJ DMH7IDQ MN Carbonic anhydrase II (CA-II) DMH7IDQ MT DTT DMH7IDQ MA Inhibitor DMH7IDQ RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DMH7IDQ RU https://pubmed.ncbi.nlm.nih.gov/10592235 DMPIHLS DI DMPIHLS DMPIHLS DN Diclofenac DMPIHLS MI DTI7UX6 DMPIHLS MN Breast cancer resistance protein (ABCG2) DMPIHLS MT DTP DMPIHLS MA Substrate DMPIHLS RN Transport of diclofenac by breast cancer resistance protein (ABCG2) and stimulation of multidrug resistance protein 2 (ABCC2)-mediated drug transport by diclofenac and benzbromarone. Drug Metab Dispos. 2009 Jan;37(1):129-36. DMPIHLS RU http://www.ncbi.nlm.nih.gov/pubmed/18845662 DMPIHLS DI DMPIHLS DMPIHLS DN Diclofenac DMPIHLS MI DEKP5HX DMPIHLS MN Cholesterol 24-hydroxylase (CYP46A1) DMPIHLS MT DME DMPIHLS MA Metabolism DMPIHLS RN Broad substrate specificity of human cytochrome P450 46A1 which initiates cholesterol degradation in the brain. Biochemistry. 2003 Dec 9;42(48):14284-92. DMPIHLS RU https://www.ncbi.nlm.nih.gov/pubmed/?term=14640697 DMPIHLS DI DMPIHLS DMPIHLS DN Diclofenac DMPIHLS MI DE4OGUF DMPIHLS MN Cytochrome P450 102A1 (cyp102) DMPIHLS MT DME DMPIHLS MA Metabolism DMPIHLS RN Both reactivity and accessibility are important in cytochrome P450 metabolism: a combined DFT and MD study of fenamic acids in BM3 mutants. J Chem Inf Model. 2019 Feb 25;59(2):743-753. DMPIHLS RU https://pubmed.ncbi.nlm.nih.gov/30758202 DMPIHLS DI DMPIHLS DMPIHLS DN Diclofenac DMPIHLS MI DECV2ME DMPIHLS MN Cytochrome P450 105D7 (cyp105) DMPIHLS MT DME DMPIHLS MA Metabolism DMPIHLS RN The metagenome of Caracolus marginella gut microbiome using culture independent approaches and shotgun sequencing. Data Brief. 2017 Nov 22;16:501-505. DMPIHLS RU https://pubmed.ncbi.nlm.nih.gov/29270447 DMPIHLS DI DMPIHLS DMPIHLS DN Diclofenac DMPIHLS MI DE6OQ3W DMPIHLS MN Cytochrome P450 1A1 (CYP1A1) DMPIHLS MT DME DMPIHLS MA Metabolism DMPIHLS RN Diclofenac and its derivatives as tools for studying human cytochromes P450 active sites: particular efficiency and regioselectivity of P450 2Cs. Biochemistry. 1999 Oct 26;38(43):14264-70. DMPIHLS RU https://www.ncbi.nlm.nih.gov/pubmed/?term=10572000 DMPIHLS DI DMPIHLS DMPIHLS DN Diclofenac DMPIHLS MI DEJGDUW DMPIHLS MN Cytochrome P450 1A2 (CYP1A2) DMPIHLS MT DME DMPIHLS MA Metabolism DMPIHLS RN Metabolism and metabolic inhibition of xanthotoxol in human liver microsomes. Evid Based Complement Alternat Med. 2016;2016:5416509. DMPIHLS RU https://www.ncbi.nlm.nih.gov/pubmed/?term=27034690 DMPIHLS DI DMPIHLS DMPIHLS DN Diclofenac DMPIHLS MI DEPKLMQ DMPIHLS MN Cytochrome P450 2B6 (CYP2B6) DMPIHLS MT DME DMPIHLS MA Metabolism DMPIHLS RN Hepatic metabolism of diclofenac: role of human CYP in the minor oxidative pathways. Biochem Pharmacol. 1999 Sep 1;58(5):787-96. DMPIHLS RU https://www.ncbi.nlm.nih.gov/pubmed/?term=10449188 DMPIHLS DI DMPIHLS DMPIHLS DN Diclofenac DMPIHLS MI DEZMWRE DMPIHLS MN Cytochrome P450 2C18 (CYP2C18) DMPIHLS MT DME DMPIHLS MA Metabolism DMPIHLS RN Diclofenac and its derivatives as tools for studying human cytochromes P450 active sites: particular efficiency and regioselectivity of P450 2Cs. Biochemistry. 1999 Oct 26;38(43):14264-70. DMPIHLS RU https://www.ncbi.nlm.nih.gov/pubmed/?term=10572000 DMPIHLS DI DMPIHLS DMPIHLS DN Diclofenac DMPIHLS MI DES5XRU DMPIHLS MN Cytochrome P450 2C8 (CYP2C8) DMPIHLS MT DME DMPIHLS MA Metabolism DMPIHLS RN Analysis of human cytochrome P450 2C8 substrate specificity using a substrate pharmacophore and site-directed mutants. Biochemistry. 2004 Dec 14;43(49):15379-92. DMPIHLS RU https://www.ncbi.nlm.nih.gov/pubmed/?term=15581350 DMPIHLS DI DMPIHLS DMPIHLS DN Diclofenac DMPIHLS MI DE5IED8 DMPIHLS MN Cytochrome P450 2C9 (CYP2C9) DMPIHLS MT DME DMPIHLS MA Metabolism DMPIHLS RN New insights into the structural features and functional relevance of human cytochrome P450 2C9. Part I. Curr Drug Metab. 2009 Dec;10(10):1075-126. DMPIHLS RU https://www.ncbi.nlm.nih.gov/pubmed/?term=20167001 DMPIHLS DI DMPIHLS DMPIHLS DN Diclofenac DMPIHLS MI DE4LYSA DMPIHLS MN Cytochrome P450 3A4 (CYP3A4) DMPIHLS MT DME DMPIHLS MA Metabolism DMPIHLS RN Cytochrome P450 3A4-mediated interaction of diclofenac and quinidine. Drug Metab Dispos. 2000 Sep;28(9):1043-50. DMPIHLS RU https://www.ncbi.nlm.nih.gov/pubmed/?term=10950847 DMPIHLS DI DMPIHLS DMPIHLS DN Diclofenac DMPIHLS MI DEGTFWK DMPIHLS MN Mephenytoin 4-hydroxylase (CYP2C19) DMPIHLS MT DME DMPIHLS MA Metabolism DMPIHLS RN Diclofenac and its derivatives as tools for studying human cytochromes P450 active sites: particular efficiency and regioselectivity of P450 2Cs. Biochemistry. 1999 Oct 26;38(43):14264-70. DMPIHLS RU https://www.ncbi.nlm.nih.gov/pubmed/?term=10572000 DMPIHLS DI DMPIHLS DMPIHLS DN Diclofenac DMPIHLS MI DT9C1TS DMPIHLS MN Organic anion transporting polypeptide 1B3 (SLCO1B3) DMPIHLS MT DTP DMPIHLS MA Substrate DMPIHLS RN Influence of non-steroidal anti-inflammatory drugs on organic anion transporting polypeptide (OATP) 1B1- and OATP1B3-mediated drug transport. Drug Metab Dispos. 2011 Jun;39(6):1047-53. DMPIHLS RU http://www.ncbi.nlm.nih.gov/pubmed/21389119 DMPIHLS DI DMPIHLS DMPIHLS DN Diclofenac DMPIHLS MI TTK0943 DMPIHLS MN Prostaglandin G/H synthase (COX) DMPIHLS MT DTT DMPIHLS MA Modulator DMPIHLS RN Diclofenac and NS-398, a selective cyclooxygenase-2 inhibitor, decrease agonist-induced contractions of the pig isolated ureter. Urol Res. 2000 Dec;28(6):376-82. DMPIHLS RU https://pubmed.ncbi.nlm.nih.gov/11221916 DMPIHLS DI DMPIHLS DMPIHLS DN Diclofenac DMPIHLS MI DEF2WXN DMPIHLS MN UDP-glucuronosyltransferase 1A3 (UGT1A3) DMPIHLS MT DME DMPIHLS MA Metabolism DMPIHLS RN Glucuronidation of nonsteroidal anti-inflammatory drugs: identifying the enzymes responsible in human liver microsomes. Drug Metab Dispos. 2005 Jul;33(7):1027-35. DMPIHLS RU https://www.ncbi.nlm.nih.gov/pubmed/?term=15843492 DMPIHLS DI DMPIHLS DMPIHLS DN Diclofenac DMPIHLS MI DE85D2P DMPIHLS MN UDP-glucuronosyltransferase 1A9 (UGT1A9) DMPIHLS MT DME DMPIHLS MA Metabolism DMPIHLS RN Glucuronidation of nonsteroidal anti-inflammatory drugs: identifying the enzymes responsible in human liver microsomes. Drug Metab Dispos. 2005 Jul;33(7):1027-35. DMPIHLS RU https://www.ncbi.nlm.nih.gov/pubmed/?term=15843492 DMPIHLS DI DMPIHLS DMPIHLS DN Diclofenac DMPIHLS MI DEB3CV1 DMPIHLS MN UDP-glucuronosyltransferase 2B7 (UGT2B7) DMPIHLS MT DME DMPIHLS MA Metabolism DMPIHLS RN Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. DMPIHLS RU https://www.ncbi.nlm.nih.gov/pubmed/?term=19515014 DM8EU0Z DI DM8EU0Z DM8EU0Z DN Dicloxacillin DM8EU0Z MI TTJP4SM DM8EU0Z MN Bacterial Penicillin binding protein (Bact PBP) DM8EU0Z MT DTT DM8EU0Z MA Binder DM8EU0Z RN Mechanisms of resistance to beta-lactam antibiotics in Staphylococcus aureus. Scand J Infect Dis Suppl. 1984;42:64-71. DM8EU0Z RU https://pubmed.ncbi.nlm.nih.gov/6335600 DM8EU0Z DI DM8EU0Z DM8EU0Z DN Dicloxacillin DM8EU0Z MI DT9G7XN DM8EU0Z MN Peptide transporter 1 (SLC15A1) DM8EU0Z MT DTP DM8EU0Z MA Substrate DM8EU0Z RN Transport characteristics of a novel peptide transporter 1 substrate, antihypotensive drug midodrine, and its amino acid derivatives. J Pharmacol Exp Ther. 2006 Jul;318(1):455-60. DM8EU0Z RU http://www.ncbi.nlm.nih.gov/pubmed/16597710 DM8EU0Z DI DM8EU0Z DM8EU0Z DN Dicloxacillin DM8EU0Z MI DT8QKNP DM8EU0Z MN Peptide transporter 2 (SLC15A2) DM8EU0Z MT DTP DM8EU0Z MA Substrate DM8EU0Z RN Transport characteristics of a novel peptide transporter 1 substrate, antihypotensive drug midodrine, and its amino acid derivatives. J Pharmacol Exp Ther. 2006 Jul;318(1):455-60. DM8EU0Z RU http://www.ncbi.nlm.nih.gov/pubmed/16597710 DM8EU0Z DI DM8EU0Z DM8EU0Z DN Dicloxacillin DM8EU0Z MI DTUGYRD DM8EU0Z MN P-glycoprotein 1 (ABCB1) DM8EU0Z MT DTP DM8EU0Z MA Substrate DM8EU0Z RN Can the enhanced renal clearance of antibiotics in cystic fibrosis patients be explained by P-glycoprotein transport? Pharm Res. 2002 Apr;19(4):457-62. DM8EU0Z RU http://www.ncbi.nlm.nih.gov/pubmed/12033380 DMFQCB1 DI DMFQCB1 DMFQCB1 DN Dicumarol DMFQCB1 MI DE5IED8 DMFQCB1 MN Cytochrome P450 2C9 (CYP2C9) DMFQCB1 MT DME DMFQCB1 MA Metabolism DMFQCB1 RN Pharmacogenetics aspects of oral anticoagulants therapy. J Med Life. 2015 Apr-Jun;8(2):171-5. DMFQCB1 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=25866574 DMFQCB1 DI DMFQCB1 DMFQCB1 DN Dicumarol DMFQCB1 MI TTEUC8H DMFQCB1 MN Vitamin K epoxide reductase complex 1 (VKORC1) DMFQCB1 MT DTT DMFQCB1 MA Inhibitor DMFQCB1 RN Vitamin K antagonism of coumarin intoxication in the rat. Thromb Haemost. 1986 Apr 30;55(2):235-9. DMFQCB1 RU https://pubmed.ncbi.nlm.nih.gov/2424118 DMZSDGX DI DMZSDGX DMZSDGX DN Dicyclomine DMZSDGX MI TTZ9SOR DMZSDGX MN Muscarinic acetylcholine receptor M1 (CHRM1) DMZSDGX MT DTT DMZSDGX MA Antagonist DMZSDGX RN [Characterization of muscarinic receptors in undifferentiated thyroid cells in Fisher rats]. Endocrinol Nutr. 2009 Mar;56(3):106-11. DMZSDGX RU https://pubmed.ncbi.nlm.nih.gov/19627722 DMI2QPE DI DMI2QPE DMI2QPE DN Didanosine DMI2QPE MI DT82KPY DMI2QPE MN Concentrative nucleoside transporter 2 (SLC28A2) DMI2QPE MT DTP DMI2QPE MA Substrate DMI2QPE RN Clinical Nephrotoxins: Renal Injury from Drugs and Chemicals. DMI2QPE RU https://books.google.co.jp/books?id=cYBGAAAAQBAJ&pg=PA59&lpg=PA59&dq=SLC15A1%09Didanosine&source=bl&ots=CeeUnMnW6Z&sig=ACfU3U10UhN6m18-AuKuLOfFeDKtUo5VYw&hl=zh-CN&sa=X&ved=2ahUKEwjh_IyK9KHiAhVIzbwKHZKiDoMQ6AEwAXoECAgQAQ#v=onepage&q=SLC15A1%09Didanosine&f=false DMI2QPE DI DMI2QPE DMI2QPE DN Didanosine DMI2QPE MI TT84ETX DMI2QPE MN Human immunodeficiency virus Reverse transcriptase (HIV RT) DMI2QPE MT DTT DMI2QPE MA Inhibitor DMI2QPE RN The effect of individual antiretroviral drugs on body composition in HIV-infected persons initiating highly active antiretroviral therapy. J Acquir Immune Defic Syndr. 2009 Jul 1;51(3):298-304. DMI2QPE RU https://pubmed.ncbi.nlm.nih.gov/19412117 DMBSXI0 DI DMBSXI0 DMBSXI0 DN Dienestrol DMBSXI0 MI TTZAYWL DMBSXI0 MN Estrogen receptor (ESR) DMBSXI0 MT DTT DMBSXI0 MA Agonist DMBSXI0 RN Potential use of an estrogen-glucocorticoid receptor chimera as a drug screen for tissue selective estrogenic activity. Bone. 2009 Jan;44(1):102-12. DMBSXI0 RU https://pubmed.ncbi.nlm.nih.gov/18976723 DM1TJ8F DI DM1TJ8F DM1TJ8F DN Diethylcarbamazine DM1TJ8F MI TT2J34L DM1TJ8F MN Arachidonate 5-lipoxygenase (5-LOX) DM1TJ8F MT DTT DM1TJ8F MA Inhibitor DM1TJ8F RN Inhibition of leukotriene formation by diethylcarbamazine modifies the acid-base balance in the rabbits with blast injuries of the lungs. Vojnosanit Pregl. 1999 May-Jun;56(3):243-7. DM1TJ8F RU https://pubmed.ncbi.nlm.nih.gov/10518442 DMN3UXQ DI DMN3UXQ DMN3UXQ DN Diethylstilbestrol DMN3UXQ MI DES5XRU DMN3UXQ MN Cytochrome P450 2C8 (CYP2C8) DMN3UXQ MT DME DMN3UXQ MA Metabolism DMN3UXQ RN Reversible inhibition of four important human liver cytochrome P450 enzymes by diethylstilbestrol. Pharmazie. 2011 Mar;66(3):216-21. DMN3UXQ RU https://www.ncbi.nlm.nih.gov/pubmed/?term=21553654 DMN3UXQ DI DMN3UXQ DMN3UXQ DN Diethylstilbestrol DMN3UXQ MI DE4LYSA DMN3UXQ MN Cytochrome P450 3A4 (CYP3A4) DMN3UXQ MT DME DMN3UXQ MA Metabolism DMN3UXQ RN Comparative analysis of human CYP3A4 and rat CYP3A1 induction and relevant gene expression by bisphenol A and diethylstilbestrol: implications for toxicity testing paradigms. Reprod Toxicol. 2013 Jun;37:24-30. DMN3UXQ RU https://www.ncbi.nlm.nih.gov/pubmed/?term=23384967 DMN3UXQ DI DMN3UXQ DMN3UXQ DN Diethylstilbestrol DMN3UXQ MI TTZAYWL DMN3UXQ MN Estrogen receptor (ESR) DMN3UXQ MT DTT DMN3UXQ MA Agonist DMN3UXQ RN Effects of diethylstilbestrol on programmed oocyte death and induction of polyovular follicles in neonatal mouse ovaries. Biol Reprod. 2009 Nov;81(5):1002-9. DMN3UXQ RU https://pubmed.ncbi.nlm.nih.gov/19553606 DMN3UXQ DI DMN3UXQ DMN3UXQ DN Diethylstilbestrol DMN3UXQ MI DTUGYRD DMN3UXQ MN P-glycoprotein 1 (ABCB1) DMN3UXQ MT DTP DMN3UXQ MA Substrate DMN3UXQ RN Antiestrogens and steroid hormones: substrates of the human P-glycoprotein. Biochem Pharmacol. 1994 Jul 19;48(2):287-92. DMN3UXQ RU http://www.ncbi.nlm.nih.gov/pubmed/7914405 DMI9PRJ DI DMI9PRJ DMI9PRJ DN Diflorasone DMI9PRJ MI TT9V5JH DMI9PRJ MN Phospholipase A2 (PLA2G1B) DMI9PRJ MT DTT DMI9PRJ MA Inhibitor DMI9PRJ RN Structures from powders: diflorasone diacetate. Steroids. 2009 Jan;74(1):102-11. DMI9PRJ RU https://pubmed.ncbi.nlm.nih.gov/19013475 DM7EN8I DI DM7EN8I DM7EN8I DN Diflunisal DM7EN8I MI TTVKILB DM7EN8I MN Prostaglandin G/H synthase 2 (COX-2) DM7EN8I MT DTT DM7EN8I MA Inhibitor DM7EN8I RN Celecoxib and rofecoxib. The role of COX-2 inhibitors in dental practice. J Am Dent Assoc. 2001 Apr;132(4):451-6. DM7EN8I RU https://pubmed.ncbi.nlm.nih.gov/11315375 DM7EN8I DI DM7EN8I DM7EN8I DN Diflunisal DM7EN8I MI DEYGVN4 DM7EN8I MN UDP-glucuronosyltransferase 1A1 (UGT1A1) DM7EN8I MT DME DM7EN8I MA Metabolism DM7EN8I RN Differential effects of phenobarbital on ester and ether glucuronidation of diflunisal in rats. J Pharmacol Exp Ther. 1987 Sep;242(3):1013-8. DM7EN8I RU https://www.ncbi.nlm.nih.gov/pubmed/?term=3656106 DMMFVB3 DI DMMFVB3 DMMFVB3 DN Difluprednate DMMFVB3 MI DE4LYSA DMMFVB3 MN Cytochrome P450 3A4 (CYP3A4) DMMFVB3 MT DME DMMFVB3 MA Metabolism DMMFVB3 RN Prevalence of non-cytochrome P450-mediated metabolism in food and drug administration-approved oral and intravenous drugs: 2006-2015. Drug Metab Dispos. 2016 Aug;44(8):1246-52. DMMFVB3 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=27084892 DMMFVB3 DI DMMFVB3 DMMFVB3 DN Difluprednate DMMFVB3 MI TTUCK4B DMMFVB3 MN Phospholipase A2 inhibitory protein (PA2IP) DMMFVB3 MT DTT DMMFVB3 MA Agonist DMMFVB3 RN 2008 FDA drug approvals. Nat Rev Drug Discov. 2009 Feb;8(2):93-6. DMMFVB3 RU https://pubmed.ncbi.nlm.nih.gov/19180096 DMWVIGP DI DMWVIGP DMWVIGP DN Digitoxin DMWVIGP MI DE4LYSA DMWVIGP MN Cytochrome P450 3A4 (CYP3A4) DMWVIGP MT DME DMWVIGP MA Metabolism DMWVIGP RN Species differences in the toxicity and cytochrome P450 IIIA-dependent metabolism of digitoxin. Mol Pharmacol. 1991 Nov;40(5):859-67. DMWVIGP RU https://www.ncbi.nlm.nih.gov/pubmed/?term=1944247 DMWVIGP DI DMWVIGP DMWVIGP DN Digitoxin DMWVIGP MI DTUGYRD DMWVIGP MN P-glycoprotein 1 (ABCB1) DMWVIGP MT DTP DMWVIGP MA Substrate DMWVIGP RN The association of ABCB1 polymorphisms and elevated serum digitoxin concentrations in geriatric patients. Eur J Clin Pharmacol. 2008 Apr;64(4):367-72. DMWVIGP RU http://www.ncbi.nlm.nih.gov/pubmed/18080812 DMWVIGP DI DMWVIGP DMWVIGP DN Digitoxin DMWVIGP MI TTQ38E9 DMWVIGP MN Sodium/potassium-transporting ATPase (SPT ATPase) DMWVIGP MT DTT DMWVIGP MA Inhibitor DMWVIGP RN Treatment of congestive heart failure--current status of use of digitoxin. Eur J Clin Invest. 2001;31 Suppl 2:10-7. DMWVIGP RU https://pubmed.ncbi.nlm.nih.gov/11525233 DMWVIGP DI DMWVIGP DMWVIGP DN Digitoxin DMWVIGP MI DEYWLRK DMWVIGP MN Sulfotransferase 1A1 (SULT1A1) DMWVIGP MT DME DMWVIGP MA Metabolism DMWVIGP RN Hydroxysteroid sulfotransferase and a specific UDP-glucuronosyltransferase are involved in the metabolism of digitoxin in man. Naunyn Schmiedebergs Arch Pharmacol. 1992 Aug;346(2):226-33. DMWVIGP RU https://www.ncbi.nlm.nih.gov/pubmed/?term=1448185 DMWVIGP DI DMWVIGP DMWVIGP DN Digitoxin DMWVIGP MI DEYGVN4 DMWVIGP MN UDP-glucuronosyltransferase 1A1 (UGT1A1) DMWVIGP MT DME DMWVIGP MA Metabolism DMWVIGP RN Use of a human liver microsome bank in drug glucuronidation studies. Toxicol In Vitro. 1991;5(5-6):559-62. DMWVIGP RU https://www.ncbi.nlm.nih.gov/pubmed/?term=20732077 DMQCTIH DI DMQCTIH DMQCTIH DN Digoxin DMQCTIH MI DE84PFW DMQCTIH MN Cardiac glycoside reductase 1 (cgr1) DMQCTIH MT DME DMQCTIH MA Metabolism DMQCTIH RN Mechanistic insight into digoxin inactivation by Eggerthella lenta augments our understanding of its pharmacokinetics. Gut Microbes. 2014 Mar-Apr;5(2):233-8. DMQCTIH RU https://pubmed.ncbi.nlm.nih.gov/24637603 DMQCTIH DI DMQCTIH DMQCTIH DN Digoxin DMQCTIH MI DE9VSLW DMQCTIH MN Cardiac glycoside reductase 2 (cgr2) DMQCTIH MT DME DMQCTIH MA Metabolism DMQCTIH RN Mechanistic insight into digoxin inactivation by Eggerthella lenta augments our understanding of its pharmacokinetics. Gut Microbes. 2014 Mar-Apr;5(2):233-8. DMQCTIH RU https://pubmed.ncbi.nlm.nih.gov/24637603 DMQCTIH DI DMQCTIH DMQCTIH DN Digoxin DMQCTIH MI DE4LYSA DMQCTIH MN Cytochrome P450 3A4 (CYP3A4) DMQCTIH MT DME DMQCTIH MA Metabolism DMQCTIH RN Omeprazole-associated digoxin toxicity. South Med J. 2007 Apr;100(4):400-2. DMQCTIH RU https://www.ncbi.nlm.nih.gov/pubmed/?term=17458401 DMQCTIH DI DMQCTIH DMQCTIH DN Digoxin DMQCTIH MI DTZRMK5 DMQCTIH MN Multidrug resistance protein 3 (ABCB4) DMQCTIH MT DTP DMQCTIH MA Substrate DMQCTIH RN MDR3 P-glycoprotein, a phosphatidylcholine translocase, transports several cytotoxic drugs and directly interacts with drugs as judged by interference with nucleotide trapping. J Biol Chem. 2000 Aug 4;275(31):23530-9. DMQCTIH RU http://www.ncbi.nlm.nih.gov/pubmed/10918072 DMQCTIH DI DMQCTIH DMQCTIH DN Digoxin DMQCTIH MI TTACFNR DMQCTIH MN Organic anion transporter M1 (SLCO4C1) DMQCTIH MT DTT DMQCTIH MA Modulator DMQCTIH RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1227). DMQCTIH RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1227 DMQCTIH DI DMQCTIH DMQCTIH DN Digoxin DMQCTIH MI DT9C1TS DMQCTIH MN Organic anion transporting polypeptide 1B3 (SLCO1B3) DMQCTIH MT DTP DMQCTIH MA Substrate DMQCTIH RN Organic anion-transporting polypeptide B (OATP-B) and its functional comparison with three other OATPs of human liver. Gastroenterology. 2001 Feb;120(2):525-33. DMQCTIH RU http://www.ncbi.nlm.nih.gov/pubmed/11159893 DMQCTIH DI DMQCTIH DMQCTIH DN Digoxin DMQCTIH MI DTPFTEQ DMQCTIH MN Organic anion transporting polypeptide 2B1 (SLCO2B1) DMQCTIH MT DTP DMQCTIH MA Substrate DMQCTIH RN Drug Interactions in Infectious Diseases. DMQCTIH RU http://www.springer.com/medicine/internal/book/978-1-61779-212-0 DMQCTIH DI DMQCTIH DMQCTIH DN Digoxin DMQCTIH MI DTY0QMU DMQCTIH MN Organic anion transporting polypeptide 4C1 (SLCO4C1) DMQCTIH MT DTP DMQCTIH MA Substrate DMQCTIH RN Isolation and characterization of a digoxin transporter and its rat homologue expressed in the kidney. Proc Natl Acad Sci U S A. 2004 Mar 9;101(10):3569-74. DMQCTIH RU http://www.ncbi.nlm.nih.gov/pubmed/14993604 DMQCTIH DI DMQCTIH DMQCTIH DN Digoxin DMQCTIH MI DTMEQ32 DMQCTIH MN Organic solute transporter subunit alpha (SLC51A) DMQCTIH MT DTP DMQCTIH MA Substrate DMQCTIH RN Functional complementation between a novel mammalian polygenic transport complex and an evolutionarily ancient organic solute transporter, OSTalpha-OSTbeta. J Biol Chem. 2003 Jul 25;278(30):27473-82. DMQCTIH RU http://www.ncbi.nlm.nih.gov/pubmed/12719432 DMQCTIH DI DMQCTIH DMQCTIH DN Digoxin DMQCTIH MI DT1V9AJ DMQCTIH MN Organic solute transporter subunit beta (SLC51B) DMQCTIH MT DTP DMQCTIH MA Substrate DMQCTIH RN Functional complementation between a novel mammalian polygenic transport complex and an evolutionarily ancient organic solute transporter, OSTalpha-OSTbeta. J Biol Chem. 2003 Jul 25;278(30):27473-82. DMQCTIH RU http://www.ncbi.nlm.nih.gov/pubmed/12719432 DMQCTIH DI DMQCTIH DMQCTIH DN Digoxin DMQCTIH MI DTUGYRD DMQCTIH MN P-glycoprotein 1 (ABCB1) DMQCTIH MT DTP DMQCTIH MA Substrate DMQCTIH RN MDR1 function is sensitive to the phosphorylation state of myosin regulatory light chain. Biochem Biophys Res Commun. 2010 Jul 16;398(1):7-12. DMQCTIH RU http://www.ncbi.nlm.nih.gov/pubmed/20510202 DMQCTIH DI DMQCTIH DMQCTIH DN Digoxin DMQCTIH MI TTQ38E9 DMQCTIH MN Sodium/potassium-transporting ATPase (SPT ATPase) DMQCTIH MT DTT DMQCTIH MA Inhibitor DMQCTIH RN Fab antibody fragments: some applications in clinical toxicology. Drug Saf. 2004;27(14):1115-33. DMQCTIH RU https://pubmed.ncbi.nlm.nih.gov/15554746 DMZIXU9 DI DMZIXU9 DMZIXU9 DN Dihydralazine DMZIXU9 MI DEJGDUW DMZIXU9 MN Cytochrome P450 1A2 (CYP1A2) DMZIXU9 MT DME DMZIXU9 MA Metabolism DMZIXU9 RN Mechanism-based inactivation of cytochrome P450s 1A2 and 3A4 by dihydralazine in human liver microsomes. Chem Res Toxicol. 1999 Oct;12(10):1028-32. DMZIXU9 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=10525281 DMZIXU9 DI DMZIXU9 DMZIXU9 DN Dihydralazine DMZIXU9 MI DE4LYSA DMZIXU9 MN Cytochrome P450 3A4 (CYP3A4) DMZIXU9 MT DME DMZIXU9 MA Metabolism DMZIXU9 RN Mechanism-based inhibition of cytochrome P450 3A4 by therapeutic drugs. Clin Pharmacokinet. 2005;44(3):279-304. DMZIXU9 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=15762770 DMZIXU9 DI DMZIXU9 DMZIXU9 DN Dihydralazine DMZIXU9 MI DEZV4AP DMZIXU9 MN RNA cytidine acetyltransferase (hALP) DMZIXU9 MT DME DMZIXU9 MA Metabolism DMZIXU9 RN The influence of the acetylator phenotype for the clinical use of dihydralazine. Int J Clin Pharmacol Ther Toxicol. 1985 Apr;23 Suppl 1:S74-8. DMZIXU9 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=3842694 DMBXVMZ DI DMBXVMZ DMBXVMZ DN Dihydroartemisinin DMBXVMZ MI TTZVSJ2 DMBXVMZ MN Sarcoplasmic/endoplasmic reticulum calcium ATPase (ATP2A) DMBXVMZ MT DTT DMBXVMZ MA Inhibitor DMBXVMZ RN The fight against drug-resistant malaria: novel plasmodial targets and antimalarial drugs. Curr Med Chem. 2008;15(2):161-71. DMBXVMZ RU https://pubmed.ncbi.nlm.nih.gov/18220771 DMBXVMZ DI DMBXVMZ DMBXVMZ DN Dihydroartemisinin DMBXVMZ MI DE85D2P DMBXVMZ MN UDP-glucuronosyltransferase 1A9 (UGT1A9) DMBXVMZ MT DME DMBXVMZ MA Metabolism DMBXVMZ RN Eurartesim - European Medicines Agency DMBXVMZ RU http://www.ema.europa.eu/docs/en_GB/document_library/EPAR_-_Public_assessment_report/human/001199/WC500118116.pdf DMBXVMZ DI DMBXVMZ DMBXVMZ DN Dihydroartemisinin DMBXVMZ MI DEB3CV1 DMBXVMZ MN UDP-glucuronosyltransferase 2B7 (UGT2B7) DMBXVMZ MT DME DMBXVMZ MA Metabolism DMBXVMZ RN Eurartesim - European Medicines Agency DMBXVMZ RU http://www.ema.europa.eu/docs/en_GB/document_library/EPAR_-_Public_assessment_report/human/001199/WC500118116.pdf DM5SQ1G DI DM5SQ1G DM5SQ1G DN Dihydroergocristine DM5SQ1G MI TT2NUT5 DM5SQ1G MN Adrenergic receptor alpha-2C (ADRA2C) DM5SQ1G MT DTT DM5SQ1G MA Modulator DM5SQ1G RN Effect of dihydroergocristine on blood pressure and activity at peripheral alpha-adrenoceptors in pithed rats. Eur J Pharmacol. 1984 Jan 13;97(1-2):21-7. DM5SQ1G RU https://pubmed.ncbi.nlm.nih.gov/6321209 DM5SQ1G DI DM5SQ1G DM5SQ1G DN Dihydroergocristine DM5SQ1G MI DTUGYRD DM5SQ1G MN P-glycoprotein 1 (ABCB1) DM5SQ1G MT DTP DM5SQ1G MA Substrate DM5SQ1G RN Interaction of cytochrome P450 3A inhibitors with P-glycoprotein. J Pharmacol Exp Ther. 2002 Oct;303(1):323-32. DM5SQ1G RU https://doi.org/10.1124/jpet.102.037549 DM5IKUF DI DM5IKUF DM5IKUF DN Dihydroergotamine DM5IKUF MI DE4LYSA DM5IKUF MN Cytochrome P450 3A4 (CYP3A4) DM5IKUF MT DME DM5IKUF MA Metabolism DM5IKUF RN CYP2D6 and CYP3A4 involvement in the primary oxidative metabolism of hydrocodone by human liver microsomes. Br J Clin Pharmacol. 2004 Mar;57(3):287-97. DM5IKUF RU https://www.ncbi.nlm.nih.gov/pubmed/?term=14998425 DM5IKUF DI DM5IKUF DM5IKUF DN Dihydroergotamine DM5IKUF MI TTEX248 DM5IKUF MN Dopamine D2 receptor (D2R) DM5IKUF MT DTT DM5IKUF MA Agonist DM5IKUF RN Current and prospective pharmacological targets in relation to antimigraine action. Naunyn Schmiedebergs Arch Pharmacol. 2008 Oct;378(4):371-94. DM5IKUF RU https://pubmed.ncbi.nlm.nih.gov/18626630 DM5D6WZ DI DM5D6WZ DM5D6WZ DN Dihydroergotoxine DM5D6WZ MI TTEX248 DM5D6WZ MN Dopamine D2 receptor (D2R) DM5D6WZ MT DTT DM5D6WZ MA Agonist DM5D6WZ RN Pharmacologic management of Alzheimer disease, Part II: Antioxidants, antihypertensives, and ergoloid derivatives. Ann Pharmacother. 1999 Feb;33(2):188-97. DM5D6WZ RU https://pubmed.ncbi.nlm.nih.gov/10084415 DM5D6WZ DI DM5D6WZ DM5D6WZ DN Dihydroergotoxine DM5D6WZ MI TTAN6JD DM5D6WZ MN Glutamate receptor AMPA (GRIA) DM5D6WZ MT DTT DM5D6WZ MA Agonist DM5D6WZ RN Pharmacologic management of Alzheimer disease, Part II: Antioxidants, antihypertensives, and ergoloid derivatives. Ann Pharmacother. 1999 Feb;33(2):188-97. DM5D6WZ RU https://pubmed.ncbi.nlm.nih.gov/10084415 DMFB97P DI DMFB97P DMFB97P DN Dihydrotachysterol DMFB97P MI TTK59TV DMFB97P MN Vitamin D3 receptor (VDR) DMFB97P MT DTT DMFB97P MA Antagonist DMFB97P RN In vivo metabolism of the vitamin D analog, dihydrotachysterol. Evidence for formation of 1 alpha,25- and 1 beta,25-dihydroxy-dihydrotachysterol metabolites and studies of their biological activity. J Biol Chem. 1993 Jan 5;268(1):282-92. DMFB97P RU https://pubmed.ncbi.nlm.nih.gov/8380156 DMM1LG2 DI DMM1LG2 DMM1LG2 DN Dihydroxyacetone DMM1LG2 MI DEX9ZJQ DMM1LG2 MN Triokinase/FMN cyclase (TKFC) DMM1LG2 MT DME DMM1LG2 MA Metabolism DMM1LG2 RN Bifunctional homodimeric triokinase/FMN cyclase: contribution of protein domains to the activities of the human enzyme and molecular dynamics simulation of domain movements. J Biol Chem. 2014 Apr 11;289(15):10620-36. DMM1LG2 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=24569995 DM8YXKW DI DM8YXKW DM8YXKW DN Dihydroxyaluminium DM8YXKW MI TT8RDXP DM8YXKW MN Troponin C (TN-C) DM8YXKW MT DTT DM8YXKW MA Stimulator DM8YXKW RN A retrospective analysis of changes in inflammatory markers in patients treated with bacterial viruses. Clin Exp Med. 2009 Dec;9(4):303-12. DM8YXKW RU https://pubmed.ncbi.nlm.nih.gov/19350363 DMAI7ZV DI DMAI7ZV DMAI7ZV DN Diltiazem DMAI7ZV MI DES5XRU DMAI7ZV MN Cytochrome P450 2C8 (CYP2C8) DMAI7ZV MT DME DMAI7ZV MA Metabolism DMAI7ZV RN Role of CYP3A4 in human hepatic diltiazem N-demethylation: inhibition of CYP3A4 activity by oxidized diltiazem metabolites. J Pharmacol Exp Ther. 1997 Jul;282(1):294-300. DMAI7ZV RU https://www.ncbi.nlm.nih.gov/pubmed/?term=9223567 DMAI7ZV DI DMAI7ZV DMAI7ZV DN Diltiazem DMAI7ZV MI DE5IED8 DMAI7ZV MN Cytochrome P450 2C9 (CYP2C9) DMAI7ZV MT DME DMAI7ZV MA Metabolism DMAI7ZV RN Drug interactions with calcium channel blockers: possible involvement of metabolite-intermediate complexation with CYP3A. Drug Metab Dispos. 2000 Feb;28(2):125-30. DMAI7ZV RU https://www.ncbi.nlm.nih.gov/pubmed/?term=10640508 DMAI7ZV DI DMAI7ZV DMAI7ZV DN Diltiazem DMAI7ZV MI DECB0K3 DMAI7ZV MN Cytochrome P450 2D6 (CYP2D6) DMAI7ZV MT DME DMAI7ZV MA Metabolism DMAI7ZV RN Drug interactions with calcium channel blockers: possible involvement of metabolite-intermediate complexation with CYP3A. Drug Metab Dispos. 2000 Feb;28(2):125-30. DMAI7ZV RU https://www.ncbi.nlm.nih.gov/pubmed/?term=10640508 DMAI7ZV DI DMAI7ZV DMAI7ZV DN Diltiazem DMAI7ZV MI DE4LYSA DMAI7ZV MN Cytochrome P450 3A4 (CYP3A4) DMAI7ZV MT DME DMAI7ZV MA Metabolism DMAI7ZV RN Comparative metabolic capabilities of CYP3A4, CYP3A5, and CYP3A7. Drug Metab Dispos. 2002 Aug;30(8):883-91. DMAI7ZV RU https://www.ncbi.nlm.nih.gov/pubmed/?term=12124305 DMAI7ZV DI DMAI7ZV DMAI7ZV DN Diltiazem DMAI7ZV MI DEIBDNY DMAI7ZV MN Cytochrome P450 3A5 (CYP3A5) DMAI7ZV MT DME DMAI7ZV MA Metabolism DMAI7ZV RN Significant impacts of CYP3A4*1G and CYP3A5*3 genetic polymorphisms on the pharmacokinetics of diltiazem and its main metabolites in Chinese adult kidney transplant patients. J Clin Pharm Ther. 2016 Jun;41(3):341-7. DMAI7ZV RU https://www.ncbi.nlm.nih.gov/pubmed/?term=27149910 DMAI7ZV DI DMAI7ZV DMAI7ZV DN Diltiazem DMAI7ZV MI DERD86B DMAI7ZV MN Cytochrome P450 3A7 (CYP3A7) DMAI7ZV MT DME DMAI7ZV MA Metabolism DMAI7ZV RN FDA Drug Development and Drug Interactions DMAI7ZV RU https://www.fda.gov/Drugs/DevelopmentApprovalProcess/DevelopmentResources/DrugInteractionsLabeling/ucm093664.htm#table3-2 DMAI7ZV DI DMAI7ZV DMAI7ZV DN Diltiazem DMAI7ZV MI DEGTFWK DMAI7ZV MN Mephenytoin 4-hydroxylase (CYP2C19) DMAI7ZV MT DME DMAI7ZV MA Metabolism DMAI7ZV RN Effects of CYP3A4 inhibition by diltiazem on pharmacokinetics and dynamics of diazepam in relation to CYP2C19 genotype status. Drug Metab Dispos. 2001 Oct;29(10):1284-9. DMAI7ZV RU https://www.ncbi.nlm.nih.gov/pubmed/?term=11560871 DMAI7ZV DI DMAI7ZV DMAI7ZV DN Diltiazem DMAI7ZV MI DTUGYRD DMAI7ZV MN P-glycoprotein 1 (ABCB1) DMAI7ZV MT DTP DMAI7ZV MA Substrate DMAI7ZV RN Mammalian drug efflux transporters of the ATP binding cassette (ABC) family in multidrug resistance: A review of the past decade. Cancer Lett. 2016 Jan 1;370(1):153-64. DMAI7ZV RU http://www.ncbi.nlm.nih.gov/pubmed/26499806 DMAI7ZV DI DMAI7ZV DMAI7ZV DN Diltiazem DMAI7ZV MI TTFK1JQ DMAI7ZV MN Voltage-gated calcium channel alpha-2/delta-1 (CACNA2D1) DMAI7ZV MT DTT DMAI7ZV MA Blocker DMAI7ZV RN Egr-1, the potential target of calcium channel blockers in cardioprotection with ischemia/reperfusion injury in rats. Cell Physiol Biochem. 2009;24(1-2):17-24. DMAI7ZV RU https://pubmed.ncbi.nlm.nih.gov/19590189 DM264B3 DI DM264B3 DM264B3 DN Dimenhydrinate DM264B3 MI TTTIBOJ DM264B3 MN Histamine H1 receptor (H1R) DM264B3 MT DTT DM264B3 MA Antagonist DM264B3 RN Histamine 1 receptor antagonist in symptomatic treatment of renal colic accompanied by nausea: two birds with one stone Urology. 2009 Jan;73(1):32-6. DM264B3 RU https://pubmed.ncbi.nlm.nih.gov/18849063 DM32YAI DI DM32YAI DM32YAI DN Dimethindene DM32YAI MI TTTIBOJ DM32YAI MN Histamine H1 receptor (H1R) DM32YAI MT DTT DM32YAI MA Antagonist DM32YAI RN Analytical method for simultaneously measuring ex vivo drug receptor occupancy and dissociation rate: application to (R)-dimethindene occupancy of central histamine H1 receptors. J Recept Signal Transduct Res. 2009;29(2):84-93. DM32YAI RU https://pubmed.ncbi.nlm.nih.gov/19308787 DMXQKSL DI DMXQKSL DMXQKSL DN Dinoprost Tromethamine DMXQKSL MI TTOFYT1 DMXQKSL MN Prostacyclin receptor (PTGIR) DMXQKSL MT DTT DMXQKSL MA Antagonist DMXQKSL RN Palmitoylation of the human prostacyclin receptor. Functional implications of palmitoylation and isoprenylation. J Biol Chem. 2003 Feb 28;278(9):6947-58. DMXQKSL RU https://pubmed.ncbi.nlm.nih.gov/12488443 DMTYOPD DI DMTYOPD DMTYOPD DN Dinoprostone DMTYOPD MI DEJGDUW DMTYOPD MN Cytochrome P450 1A2 (CYP1A2) DMTYOPD MT DME DMTYOPD MA Metabolism DMTYOPD RN Effects of polyunsaturated fatty acids on prostaglandin synthesis and cyclooxygenase-mediated DNA adduct formation by heterocyclic aromatic amines in human adenocarcinoma colon cells. Mol Carcinog. 2004 Jul;40(3):180-8. DMTYOPD RU https://www.ncbi.nlm.nih.gov/pubmed/?term=15224350 DMTYOPD DI DMTYOPD DMTYOPD DN Dinoprostone DMTYOPD MI DE3GT9C DMTYOPD MN Cytochrome P450 4F2 (CYP4F2) DMTYOPD MT DME DMTYOPD MA Metabolism DMTYOPD RN Cloning and characterization of CYP4F21: a prostaglandin E2 20-hydroxylase of ram seminal vesicles. Arch Biochem Biophys. 2001 May 1;389(1):123-9. DMTYOPD RU https://www.ncbi.nlm.nih.gov/pubmed/?term=11370662 DMTYOPD DI DMTYOPD DMTYOPD DN Dinoprostone DMTYOPD MI DTFI42L DMTYOPD MN Multidrug resistance-associated protein 2 (ABCC2) DMTYOPD MT DTP DMTYOPD MA Substrate DMTYOPD RN Multidrug resistance associated protein 2 mediates transport of prostaglandin E2. Liver Int. 2006 Apr;26(3):362-8. DMTYOPD RU https://doi.org/10.1111/j.1478-3231.2005.01234.x DMTYOPD DI DMTYOPD DMTYOPD DN Dinoprostone DMTYOPD MI DTCSGPB DMTYOPD MN Multidrug resistance-associated protein 4 (ABCC4) DMTYOPD MT DTP DMTYOPD MA Substrate DMTYOPD RN The human multidrug resistance protein MRP4 functions as a prostaglandin efflux transporter and is inhibited by nonsteroidal antiinflammatory drugs. Proc Natl Acad Sci U S A. 2003 Aug 5;100(16):9244-9. DMTYOPD RU http://www.ncbi.nlm.nih.gov/pubmed/12835412 DMTYOPD DI DMTYOPD DMTYOPD DN Dinoprostone DMTYOPD MI DTQ23VB DMTYOPD MN Organic anion transporter 1 (SLC22A6) DMTYOPD MT DTP DMTYOPD MA Substrate DMTYOPD RN Human organic anion transporters and human organic cation transporters mediate renal transport of prostaglandins. J Pharmacol Exp Ther. 2002 Apr;301(1):293-8. DMTYOPD RU http://www.ncbi.nlm.nih.gov/pubmed/11907186 DMTYOPD DI DMTYOPD DMTYOPD DN Dinoprostone DMTYOPD MI DT0OC1Q DMTYOPD MN Organic anion transporter 2 (SLC22A7) DMTYOPD MT DTP DMTYOPD MA Substrate DMTYOPD RN Human organic anion transporters and human organic cation transporters mediate renal transport of prostaglandins. J Pharmacol Exp Ther. 2002 Apr;301(1):293-8. DMTYOPD RU http://www.ncbi.nlm.nih.gov/pubmed/11907186 DMTYOPD DI DMTYOPD DMTYOPD DN Dinoprostone DMTYOPD MI DTVP67E DMTYOPD MN Organic anion transporter 3 (SLC22A8) DMTYOPD MT DTP DMTYOPD MA Substrate DMTYOPD RN Human organic anion transporters and human organic cation transporters mediate renal transport of prostaglandins. J Pharmacol Exp Ther. 2002 Apr;301(1):293-8. DMTYOPD RU http://www.ncbi.nlm.nih.gov/pubmed/11907186 DMTYOPD DI DMTYOPD DMTYOPD DN Dinoprostone DMTYOPD MI DT06JWZ DMTYOPD MN Organic anion transporter 4 (SLC22A11) DMTYOPD MT DTP DMTYOPD MA Substrate DMTYOPD RN Human organic anion transporters and human organic cation transporters mediate renal transport of prostaglandins. J Pharmacol Exp Ther. 2002 Apr;301(1):293-8. DMTYOPD RU http://www.ncbi.nlm.nih.gov/pubmed/11907186 DMTYOPD DI DMTYOPD DMTYOPD DN Dinoprostone DMTYOPD MI DTE2B1D DMTYOPD MN Organic anion transporting polypeptide 1A2 (SLCO1A2) DMTYOPD MT DTP DMTYOPD MA Substrate DMTYOPD RN Localization of organic anion transporting polypeptide 4 (Oatp4) in rat liver and comparison of its substrate specificity with Oatp1, Oatp2 and Oatp3. Pflugers Arch. 2001 Nov;443(2):188-95. DMTYOPD RU http://www.ncbi.nlm.nih.gov/pubmed/11713643 DMTYOPD DI DMTYOPD DMTYOPD DN Dinoprostone DMTYOPD MI DT3D8F0 DMTYOPD MN Organic anion transporting polypeptide 1B1 (SLCO1B1) DMTYOPD MT DTP DMTYOPD MA Substrate DMTYOPD RN Organic anion transporting polypeptide 1B1: a genetically polymorphic transporter of major importance for hepatic drug uptake. Pharmacol Rev. 2011 Mar;63(1):157-81. DMTYOPD RU http://www.ncbi.nlm.nih.gov/pubmed/21245207 DMTYOPD DI DMTYOPD DMTYOPD DN Dinoprostone DMTYOPD MI DTPYCQ4 DMTYOPD MN Organic anion transporting polypeptide 1C1 (SLCO1C1) DMTYOPD MT DTP DMTYOPD MA Substrate DMTYOPD RN Identification of a novel human organic anion transporting polypeptide as a high affinity thyroxine transporter. Mol Endocrinol. 2002 Oct;16(10):2283-96. DMTYOPD RU http://www.ncbi.nlm.nih.gov/pubmed/12351693 DMTYOPD DI DMTYOPD DMTYOPD DN Dinoprostone DMTYOPD MI DT021JD DMTYOPD MN Organic anion transporting polypeptide 2A1 (SLCO2A1) DMTYOPD MT DTP DMTYOPD MA Substrate DMTYOPD RN Molecular identification and characterization of novel members of the human organic anion transporter (OATP) family. Biochem Biophys Res Commun. 2000 Jun 24;273(1):251-60. DMTYOPD RU http://www.ncbi.nlm.nih.gov/pubmed/10873595 DMTYOPD DI DMTYOPD DMTYOPD DN Dinoprostone DMTYOPD MI DTPFTEQ DMTYOPD MN Organic anion transporting polypeptide 2B1 (SLCO2B1) DMTYOPD MT DTP DMTYOPD MA Substrate DMTYOPD RN Molecular identification and characterization of novel members of the human organic anion transporter (OATP) family. Biochem Biophys Res Commun. 2000 Jun 24;273(1):251-60. DMTYOPD RU http://www.ncbi.nlm.nih.gov/pubmed/10873595 DMTYOPD DI DMTYOPD DMTYOPD DN Dinoprostone DMTYOPD MI DTVNRXW DMTYOPD MN Organic anion transporting polypeptide 3A1 (SLCO3A1) DMTYOPD MT DTP DMTYOPD MA Substrate DMTYOPD RN Molecular characterization of human and rat organic anion transporter OATP-D. Am J Physiol Renal Physiol. 2003 Dec;285(6):F1188-97. DMTYOPD RU http://www.ncbi.nlm.nih.gov/pubmed/14631946 DMTYOPD DI DMTYOPD DMTYOPD DN Dinoprostone DMTYOPD MI DT8H2IC DMTYOPD MN Organic anion transporting polypeptide 4A1 (SLCO4A1) DMTYOPD MT DTP DMTYOPD MA Substrate DMTYOPD RN Molecular identification and characterization of novel members of the human organic anion transporter (OATP) family. Biochem Biophys Res Commun. 2000 Jun 24;273(1):251-60. DMTYOPD RU http://www.ncbi.nlm.nih.gov/pubmed/10873595 DMTYOPD DI DMTYOPD DMTYOPD DN Dinoprostone DMTYOPD MI DTYVQ5M DMTYOPD MN Organic anion transporting polypeptide 5A1 (SLCO5A1) DMTYOPD MT DTP DMTYOPD MA Substrate DMTYOPD RN Expression and regulation of prostaglandin transporters, ATP-binding cassette, subfamily C, member 1 and 9, and solute carrier organic anion transporter family, member 2A1 and 5A1 in the uterine endometrium during the estrous cycle and pregnancy in pigs. Asian-Australas J Anim Sci. 2017 May;30(5):643-652. DMTYOPD RU http://www.ncbi.nlm.nih.gov/pubmed/27764917 DMTYOPD DI DMTYOPD DMTYOPD DN Dinoprostone DMTYOPD MI DTT79CX DMTYOPD MN Organic cation transporter 1 (SLC22A1) DMTYOPD MT DTP DMTYOPD MA Substrate DMTYOPD RN Are organic cation transporters capable of transporting prostaglandins? Naunyn Schmiedebergs Arch Pharmacol. 2005 Aug;372(2):125-30. DMTYOPD RU http://www.ncbi.nlm.nih.gov/pubmed/16211406 DMTYOPD DI DMTYOPD DMTYOPD DN Dinoprostone DMTYOPD MI DT9IDPW DMTYOPD MN Organic cation transporter 2 (SLC22A2) DMTYOPD MT DTP DMTYOPD MA Substrate DMTYOPD RN Are organic cation transporters capable of transporting prostaglandins? Naunyn Schmiedebergs Arch Pharmacol. 2005 Aug;372(2):125-30. DMTYOPD RU http://www.ncbi.nlm.nih.gov/pubmed/16211406 DMTYOPD DI DMTYOPD DMTYOPD DN Dinoprostone DMTYOPD MI DTMEQ32 DMTYOPD MN Organic solute transporter subunit alpha (SLC51A) DMTYOPD MT DTP DMTYOPD MA Substrate DMTYOPD RN Functional complementation between a novel mammalian polygenic transport complex and an evolutionarily ancient organic solute transporter, OSTalpha-OSTbeta. J Biol Chem. 2003 Jul 25;278(30):27473-82. DMTYOPD RU http://www.ncbi.nlm.nih.gov/pubmed/12719432 DMTYOPD DI DMTYOPD DMTYOPD DN Dinoprostone DMTYOPD MI DT1V9AJ DMTYOPD MN Organic solute transporter subunit beta (SLC51B) DMTYOPD MT DTP DMTYOPD MA Substrate DMTYOPD RN Functional complementation between a novel mammalian polygenic transport complex and an evolutionarily ancient organic solute transporter, OSTalpha-OSTbeta. J Biol Chem. 2003 Jul 25;278(30):27473-82. DMTYOPD RU http://www.ncbi.nlm.nih.gov/pubmed/12719432 DMTYOPD DI DMTYOPD DMTYOPD DN Dinoprostone DMTYOPD MI TT1ZAVI DMTYOPD MN Prostaglandin E2 receptor EP2 (PTGER2) DMTYOPD MT DTT DMTYOPD MA Antagonist DMTYOPD RN Evaluation of WO 2012/177618 A1 and US-2014/0179750 A1: novel small molecule antagonists of prostaglandin-E2 receptor EP2.Expert Opin Ther Pat. 2015 Jul;25(7):837-44. DMTYOPD RU https://www.ncbi.nlm.nih.gov/pubmed/25772215 DMTYOPD DI DMTYOPD DMTYOPD DN Dinoprostone DMTYOPD MI TTT2ZAR DMTYOPD MN Prostaglandin F2-alpha receptor (PTGFR) DMTYOPD MT DTT DMTYOPD MA Antagonist DMTYOPD RN Evaluation of WO 2012/177618 A1 and US-2014/0179750 A1: novel small molecule antagonists of prostaglandin-E2 receptor EP2.Expert Opin Ther Pat. 2015 Jul;25(7):837-44. DMTYOPD RU https://www.ncbi.nlm.nih.gov/pubmed/25772215 DMXVU6D DI DMXVU6D DMXVU6D DN Diphemanil Methylsulfate DMXVU6D MI TTZ9SOR DMXVU6D MN Muscarinic acetylcholine receptor M1 (CHRM1) DMXVU6D MT DTT DMXVU6D MA Modulator DMXVU6D RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. DMXVU6D RU https://www.fda.gov/ DMKQTBA DI DMKQTBA DMKQTBA DN Diphenhydramine DMKQTBA MI DE5IED8 DMKQTBA MN Cytochrome P450 2C9 (CYP2C9) DMKQTBA MT DME DMKQTBA MA Metabolism DMKQTBA RN Pharmacogenomics in psychiatry: implications for practice. Recent Pat Biotechnol. 2014;8(2):152-9. DMKQTBA RU https://www.ncbi.nlm.nih.gov/pubmed/25185985 DMKQTBA DI DMKQTBA DMKQTBA DN Diphenhydramine DMKQTBA MI DECB0K3 DMKQTBA MN Cytochrome P450 2D6 (CYP2D6) DMKQTBA MT DME DMKQTBA MA Metabolism DMKQTBA RN Identification of human cytochrome p450 isozymes involved in diphenhydramine N-demethylation. Drug Metab Dispos. 2007 Jan;35(1):72-8. DMKQTBA RU https://www.ncbi.nlm.nih.gov/pubmed/?term=17020955 DMKQTBA DI DMKQTBA DMKQTBA DN Diphenhydramine DMKQTBA MI TTTIBOJ DMKQTBA MN Histamine H1 receptor (H1R) DMKQTBA MT DTT DMKQTBA MA Antagonist DMKQTBA RN Intact cell binding for in vitro prediction of sedative and non-sedative histamine H1-receptor antagonists based on receptor internalization. J Pharmacol Sci. 2008 May;107(1):66-79. DMKQTBA RU https://pubmed.ncbi.nlm.nih.gov/18446005 DMKQTBA DI DMKQTBA DMKQTBA DN Diphenhydramine DMKQTBA MI TT2B6EV DMKQTBA MN Histamine N-methyltransferase (HNMT) DMKQTBA MT DTT DMKQTBA MA Inhibitor DMKQTBA RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DMKQTBA RU https://pubmed.ncbi.nlm.nih.gov/10592235 DMKQTBA DI DMKQTBA DMKQTBA DN Diphenhydramine DMKQTBA MI DEGTFWK DMKQTBA MN Mephenytoin 4-hydroxylase (CYP2C19) DMKQTBA MT DME DMKQTBA MA Metabolism DMKQTBA RN Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. DMKQTBA RU https://www.ncbi.nlm.nih.gov/pubmed/?term=19515014 DMKQTBA DI DMKQTBA DMKQTBA DN Diphenhydramine DMKQTBA MI DE073H6 DMKQTBA MN Prostaglandin G/H synthase 1 (COX-1) DMKQTBA MT DME DMKQTBA MA Metabolism DMKQTBA RN Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. DMKQTBA RU https://www.ncbi.nlm.nih.gov/pubmed/?term=19515014 DMHPWOM DI DMHPWOM DMHPWOM DN Diphenidol DMHPWOM MI TTQ3JTF DMHPWOM MN Muscarinic acetylcholine receptor M4 (CHRM4) DMHPWOM MT DTT DMHPWOM MA Antagonist DMHPWOM RN Diphenidol-related diamines as novel muscarinic M4 receptor antagonists. Bioorg Med Chem Lett. 2008 May 1;18(9):2972-6. DMHPWOM RU https://pubmed.ncbi.nlm.nih.gov/18395442 DMO5SZX DI DMO5SZX DMO5SZX DN Diphenoxylate DMO5SZX MI TTKWM86 DMO5SZX MN Opioid receptor mu (MOP) DMO5SZX MT DTT DMO5SZX MA Agonist DMO5SZX RN Loperamide: a pharmacological review. Rev Gastroenterol Disord. 2007;7 Suppl 3:S11-8. DMO5SZX RU https://pubmed.ncbi.nlm.nih.gov/18192961 DMW4X37 DI DMW4X37 DMW4X37 DN Diphenylpyraline DMW4X37 MI TTTIBOJ DMW4X37 MN Histamine H1 receptor (H1R) DMW4X37 MT DTT DMW4X37 MA Antagonist DMW4X37 RN Transport mechanism of an H1-antagonist at the blood-brain barrier: transport mechanism of mepyramine using the carotid injection technique. Biol Pharm Bull. 1994 May;17(5):676-9. DMW4X37 RU https://pubmed.ncbi.nlm.nih.gov/7920432 DM0FSIM DI DM0FSIM DM0FSIM DN Diphtheria-tetanus vaccine DM0FSIM MI TTXT4D5 DM0FSIM MN Bacterial Cell membrane (Bact CM) DM0FSIM MT DTT DM0FSIM RN 2006 drug approvals: finding the niche. Nat Rev Drug Discov. 2007 Feb;6(2):99-101. DM0FSIM RU https://pubmed.ncbi.nlm.nih.gov/17342860 DMH5W0G DI DMH5W0G DMH5W0G DN Dipivefrin DMH5W0G MI TTR6W5O DMH5W0G MN Adrenergic receptor beta-1 (ADRB1) DMH5W0G MT DTT DMH5W0G MA Antagonist DMH5W0G RN Contractile response of the isolated trabecular meshwork and ciliary muscle to cholinergic and adrenergic agents. Ger J Ophthalmol. 1996 May;5(3):146-53. DMH5W0G RU https://pubmed.ncbi.nlm.nih.gov/8803576 DMXY30O DI DMXY30O DMXY30O DN Dipyridamole DMXY30O MI DTI7UX6 DMXY30O MN Breast cancer resistance protein (ABCG2) DMXY30O MT DTP DMXY30O MA Substrate DMXY30O RN ABCG2: a perspective. Adv Drug Deliv Rev. 2009 Jan 31;61(1):3-13. DMXY30O RU https://doi.org/10.1016/j.addr.2008.11.003 DMXY30O DI DMXY30O DMXY30O DN Dipyridamole DMXY30O MI DTUGYRD DMXY30O MN P-glycoprotein 1 (ABCB1) DMXY30O MT DTP DMXY30O MA Substrate DMXY30O RN Improving the prediction of the brain disposition for orally administered drugs using BDDCS. Adv Drug Deliv Rev. 2012 Jan;64(1):95-109. DMXY30O RU https://doi.org/10.1016/j.addr.2011.12.008 DMXY30O DI DMXY30O DMXY30O DN Dipyridamole DMXY30O MI TTJ0IQB DMXY30O MN Phosphodiesterase 5A (PDE5A) DMXY30O MT DTT DMXY30O MA Modulator DMXY30O RN Anti-platelet therapy: phosphodiesterase inhibitors.Br J Clin Pharmacol.2011 Oct;72(4):634-46. DMXY30O RU https://www.ncbi.nlm.nih.gov/pubmed/21649691 DM0D9YJ DI DM0D9YJ DM0D9YJ DN Dirithromycin DM0D9YJ MI TTUWYEA DM0D9YJ MN Bacterial 50S ribosomal RNA (Bact 50S rRNA) DM0D9YJ MT DTT DM0D9YJ MA Binder DM0D9YJ RN Review of macrolides and ketolides: focus on respiratory tract infections. Drugs. 2001;61(4):443-98. DM0D9YJ RU https://pubmed.ncbi.nlm.nih.gov/11324679 DM0D9YJ DI DM0D9YJ DM0D9YJ DN Dirithromycin DM0D9YJ MI DTI7UX6 DM0D9YJ MN Breast cancer resistance protein (ABCG2) DM0D9YJ MT DTP DM0D9YJ MA Substrate DM0D9YJ RN Arginine-482 is not essential for transport of antibiotics, primary bile acids and unconjugated sterols by the human breast cancer resistance protein (ABCG2). Biochem J. 2005 Jan 15;385(Pt 2):419-26. DM0D9YJ RU https://doi.org/10.1042/BJ20040791 DM0D9YJ DI DM0D9YJ DM0D9YJ DN Dirithromycin DM0D9YJ MI DE4LYSA DM0D9YJ MN Cytochrome P450 3A4 (CYP3A4) DM0D9YJ MT DME DM0D9YJ MA Metabolism DM0D9YJ RN Drug-Drug interactions of clinical significance in the treatment of patients with Mycobacterium avium complex disease. Clin Pharmacokinet. 2000 Sep;39(3):203-14. DM0D9YJ RU https://www.ncbi.nlm.nih.gov/pubmed/?term=11020135 DM5SYZP DI DM5SYZP DM5SYZP DN Disopyramide DM5SYZP MI DEJGDUW DM5SYZP MN Cytochrome P450 1A2 (CYP1A2) DM5SYZP MT DME DM5SYZP MA Metabolism DM5SYZP RN Species difference in stereoselective involvement of CYP3A in the mono-N-dealkylation of disopyramide. Xenobiotica. 2001 Feb;31(2):73-83. DM5SYZP RU https://www.ncbi.nlm.nih.gov/pubmed/?term=11407536 DM5SYZP DI DM5SYZP DM5SYZP DN Disopyramide DM5SYZP MI DE4LYSA DM5SYZP MN Cytochrome P450 3A4 (CYP3A4) DM5SYZP MT DME DM5SYZP MA Metabolism DM5SYZP RN Species difference in stereoselective involvement of CYP3A in the mono-N-dealkylation of disopyramide. Xenobiotica. 2001 Feb;31(2):73-83. DM5SYZP RU https://www.ncbi.nlm.nih.gov/pubmed/?term=11407536 DM5SYZP DI DM5SYZP DM5SYZP DN Disopyramide DM5SYZP MI DTT79CX DM5SYZP MN Organic cation transporter 1 (SLC22A1) DM5SYZP MT DTP DM5SYZP MA Substrate DM5SYZP RN Identification of novel substrates and structure-activity relationship of cellular uptake mediated by human organic cation transporters 1 and 2. J Med Chem. 2013 Sep 26;56(18):7232-42. DM5SYZP RU http://www.ncbi.nlm.nih.gov/pubmed/23984907 DM5SYZP DI DM5SYZP DM5SYZP DN Disopyramide DM5SYZP MI TTZOVE0 DM5SYZP MN Voltage-gated sodium channel alpha Nav1.5 (SCN5A) DM5SYZP MT DTT DM5SYZP MA Blocker DM5SYZP RN Effect of sodium channel blockers on ST segment, QRS duration, and corrected QT interval in patients with Brugada syndrome. J Cardiovasc Electrophysiol. 2000 Dec;11(12):1320-9. DM5SYZP RU https://pubmed.ncbi.nlm.nih.gov/11196553 DMCL2OK DI DMCL2OK DMCL2OK DN Disulfiram DMCL2OK MI DEVDYN7 DMCL2OK MN Cytochrome P450 2E1 (CYP2E1) DMCL2OK MT DME DMCL2OK MA Metabolism DMCL2OK RN Duration of cytochrome P-450 2E1 (CYP2E1) inhibition and estimation of functional CYP2E1 enzyme half-life after single-dose disulfiram administration in humans. J Pharmacol Exp Ther. 1999 Oct;291(1):213-9. DMCL2OK RU https://www.ncbi.nlm.nih.gov/pubmed/?term=10490907 DMCL2OK DI DMCL2OK DMCL2OK DN Disulfiram DMCL2OK MI DE4LYSA DMCL2OK MN Cytochrome P450 3A4 (CYP3A4) DMCL2OK MT DME DMCL2OK MA Metabolism DMCL2OK RN Interaction of disulfiram with antiretroviral medications: efavirenz increases while atazanavir decreases disulfiram effect on enzymes of alcohol metabolism. Am J Addict. 2014 Mar-Apr;23(2):137-44. DMCL2OK RU https://www.ncbi.nlm.nih.gov/pubmed/?term=24118434 DMCL2OK DI DMCL2OK DMCL2OK DN Disulfiram DMCL2OK MI DEIBDNY DMCL2OK MN Cytochrome P450 3A5 (CYP3A5) DMCL2OK MT DME DMCL2OK MA Metabolism DMCL2OK RN Identification of the human P-450 enzymes responsible for the sulfoxidation and thiono-oxidation of diethyldithiocarbamate methyl ester: role of P-450 enzymes in disulfiram bioactivation. Alcohol Clin Exp Res. 1998 Sep;22(6):1212-9. DMCL2OK RU https://www.ncbi.nlm.nih.gov/pubmed/?term=9756035 DMCL2OK DI DMCL2OK DMCL2OK DN Disulfiram DMCL2OK MI TTB6UM0 DMCL2OK MN Fatty aldehyde dehydrogenase (ALDH3A2) DMCL2OK MT DTT DMCL2OK MA Inhibitor DMCL2OK RN Pharmacological treatment of alcohol dependence: target symptoms and target mechanisms. Pharmacol Ther. 2006 Sep;111(3):855-76. DMCL2OK RU https://pubmed.ncbi.nlm.nih.gov/16545872 DM4RK0G DI DM4RK0G DM4RK0G DN Divalproex sodium DM4RK0G MI TTT2LD9 DM4RK0G MN GABA transaminase (ABAT) DM4RK0G MT DTT DM4RK0G MA Inhibitor DM4RK0G RN DrugBank: a knowledgebase for drugs, drug actions and drug targets. Nucleic Acids Res. 2008 Jan;36(Database issue):D901-6. DM4RK0G RU https://pubmed.ncbi.nlm.nih.gov/18048412 DMD1B8Z DI DMD1B8Z DMD1B8Z DN Dobutamine DMD1B8Z MI TTR6W5O DMD1B8Z MN Adrenergic receptor beta-1 (ADRB1) DMD1B8Z MT DTT DMD1B8Z MA Agonist DMD1B8Z RN Beta-adrenoceptor alterations coupled with secretory response and experimental periodontitis in rat submandibular glands. Arch Oral Biol. 2008 Jun;53(6):509-16. DMD1B8Z RU https://pubmed.ncbi.nlm.nih.gov/18275933 DMD1B8Z DI DMD1B8Z DMD1B8Z DN Dobutamine DMD1B8Z MI DEV3T4A DMD1B8Z MN Catechol O-methyltransferase (COMT) DMD1B8Z MT DME DMD1B8Z MA Metabolism DMD1B8Z RN Catechol-O-methyltransferase: substrate-specificity and stereoselectivity for beta-adrenoceptor agents. Xenobiotica. 1986 Jan;16(1):47-52. DMD1B8Z RU https://www.ncbi.nlm.nih.gov/pubmed/?term=2868577 DMS5IEB DI DMS5IEB DMS5IEB DN Docarpamine DMS5IEB MI TTEX248 DMS5IEB MN Dopamine D2 receptor (D2R) DMS5IEB MT DTT DMS5IEB MA Modulator DMS5IEB RN Natural products as sources of new drugs over the last 25 years. J Nat Prod. 2007 Mar;70(3):461-77. DMS5IEB RU https://pubmed.ncbi.nlm.nih.gov/17309302 DMDI269 DI DMDI269 DMDI269 DN Docetaxel DMDI269 MI DTI7UX6 DMDI269 MN Breast cancer resistance protein (ABCG2) DMDI269 MT DTP DMDI269 MA Substrate DMDI269 RN Ixabepilone, a novel microtubule-targeting agent for breast cancer, is a substrate for P-glycoprotein (P-gp/MDR1/ABCB1) but not breast cancer resistance protein (BCRP/ABCG2). J Pharmacol Exp Ther. 2011 May;337(2):423-32. DMDI269 RU http://www.ncbi.nlm.nih.gov/pubmed/21262849 DMDI269 DI DMDI269 DMDI269 DN Docetaxel DMDI269 MI DE4LYSA DMDI269 MN Cytochrome P450 3A4 (CYP3A4) DMDI269 MT DME DMDI269 MA Metabolism DMDI269 RN Randomized pharmacokinetic and pharmacodynamic study of docetaxel: dosing based on body-surface area compared with individualized dosing based on cytochrome P450 activity estimated using a urinary metabolite of exogenous cortisol. J Clin Oncol. 2005 Feb 20;23(6):1061-9. DMDI269 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=15657405 DMDI269 DI DMDI269 DMDI269 DN Docetaxel DMDI269 MI DEIBDNY DMDI269 MN Cytochrome P450 3A5 (CYP3A5) DMDI269 MT DME DMDI269 MA Metabolism DMDI269 RN Drug Interactions Flockhart Table DMDI269 RU https://drug-interactions.medicine.iu.edu/Main-Table.aspx DMDI269 DI DMDI269 DMDI269 DN Docetaxel DMDI269 MI DERD86B DMDI269 MN Cytochrome P450 3A7 (CYP3A7) DMDI269 MT DME DMDI269 MA Metabolism DMDI269 RN Drug Interactions Flockhart Table DMDI269 RU https://drug-interactions.medicine.iu.edu/Main-Table.aspx DMDI269 DI DMDI269 DMDI269 DN Docetaxel DMDI269 MI DTSYQGK DMDI269 MN Multidrug resistance-associated protein 1 (ABCC1) DMDI269 MT DTP DMDI269 MA Substrate DMDI269 RN Human intestinal transporter database: QSAR modeling and virtual profiling of drug uptake, efflux and interactions. Pharm Res. 2013 Apr;30(4):996-1007. DMDI269 RU https://doi.org/10.1007/s11095-012-0935-x DMDI269 DI DMDI269 DMDI269 DN Docetaxel DMDI269 MI DTFI42L DMDI269 MN Multidrug resistance-associated protein 2 (ABCC2) DMDI269 MT DTP DMDI269 MA Substrate DMDI269 RN Transport of diclofenac by breast cancer resistance protein (ABCG2) and stimulation of multidrug resistance protein 2 (ABCC2)-mediated drug transport by diclofenac and benzbromarone. Drug Metab Dispos. 2009 Jan;37(1):129-36. DMDI269 RU http://www.ncbi.nlm.nih.gov/pubmed/18845662 DMDI269 DI DMDI269 DMDI269 DN Docetaxel DMDI269 MI DTPS120 DMDI269 MN Multidrug resistance-associated protein 7 (ABCC10) DMDI269 MT DTP DMDI269 MA Substrate DMDI269 RN Modulation of the ATPase and transport activities of broad-acting multidrug resistance factor ABCC10 (MRP7). Cancer Res. 2012 Dec 15;72(24):6457-67. DMDI269 RU http://www.ncbi.nlm.nih.gov/pubmed/23087055 DMDI269 DI DMDI269 DMDI269 DN Docetaxel DMDI269 MI DT3D8F0 DMDI269 MN Organic anion transporting polypeptide 1B1 (SLCO1B1) DMDI269 MT DTP DMDI269 MA Substrate DMDI269 RN FDA Drug Development and Drug Interactions DMDI269 RU https://www.fda.gov/drugs/developmentapprovalprocess/developmentresources/druginteractionslabeling/ucm093664.htm#table3-2 DMDI269 DI DMDI269 DMDI269 DN Docetaxel DMDI269 MI DT9C1TS DMDI269 MN Organic anion transporting polypeptide 1B3 (SLCO1B3) DMDI269 MT DTP DMDI269 MA Substrate DMDI269 RN Rapid screening of antineoplastic candidates for the human organic anion transporter OATP1B3 substrates using fluorescent probes. Cancer Lett. 2008 Feb 18;260(1-2):163-9. DMDI269 RU http://www.ncbi.nlm.nih.gov/pubmed/18082941 DMDI269 DI DMDI269 DMDI269 DN Docetaxel DMDI269 MI DTUGYRD DMDI269 MN P-glycoprotein 1 (ABCB1) DMDI269 MT DTP DMDI269 MA Substrate DMDI269 RN Effect of ABCB1 C3435T polymorphism on docetaxel pharmacokinetics according to menopausal status in breast cancer patients. Br J Cancer. 2010 Aug 10;103(4):560-6. DMDI269 RU http://www.ncbi.nlm.nih.gov/pubmed/20628376 DMDI269 DI DMDI269 DMDI269 DN Docetaxel DMDI269 MI DT68UV2 DMDI269 MN TAP-like protein (ABCB9) DMDI269 MT DTP DMDI269 MA Substrate DMDI269 RN RNA-sequencing dissects the transcriptome of polyploid cancer cells that are resistant to combined treatments of cisplatin with paclitaxel and docetaxel. Mol Biosyst. 2017 Sep 26;13(10):2125-2134. DMDI269 RU http://www.ncbi.nlm.nih.gov/pubmed/28825433 DMDI269 DI DMDI269 DMDI269 DN Docetaxel DMDI269 MI TTML2WA DMDI269 MN Tubulin (TUB) DMDI269 MT DTT DMDI269 MA Inhibitor DMDI269 RN Docetaxel: a review of its use in metastatic breast cancer. Drugs. 2005;65(17):2513-31. DMDI269 RU https://pubmed.ncbi.nlm.nih.gov/16296875 DMOHK1E DI DMOHK1E DMOHK1E DN Docosanol DMOHK1E MI TT1JL7D DMOHK1E MN Epstein-Barr virus Envelope glycoprotein gp340 (EBV BLLF1) DMOHK1E MT DTT DMOHK1E MA Modulator DMOHK1E RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. DMOHK1E RU https://www.fda.gov/ DMPN1TW DI DMPN1TW DMPN1TW DN Dofetilide DMPN1TW MI DE4LYSA DMPN1TW MN Cytochrome P450 3A4 (CYP3A4) DMPN1TW MT DME DMPN1TW MA Metabolism DMPN1TW RN Significance of metabolism in the disposition and action of the antidysrhythmic drug, dofetilide. In vitro studies and correlation with in vivo data. Drug Metab Dispos. 1996 Apr;24(4):447-55. DMPN1TW RU https://www.ncbi.nlm.nih.gov/pubmed/?term=8801060 DMPN1TW DI DMPN1TW DMPN1TW DN Dofetilide DMPN1TW MI DTZGT0P DMPN1TW MN Multidrug and toxin extrusion protein 1 (SLC47A1) DMPN1TW MT DTP DMPN1TW MA Substrate DMPN1TW RN FDA Drug Development and Drug Interactions DMPN1TW RU https://www.fda.gov/drugs/developmentapprovalprocess/developmentresources/druginteractionslabeling/ucm093664.htm#table3-2 DMPN1TW DI DMPN1TW DMPN1TW DN Dofetilide DMPN1TW MI DT3TX4H DMPN1TW MN Multidrug and toxin extrusion protein 2 (SLC47A2) DMPN1TW MT DTP DMPN1TW MA Substrate DMPN1TW RN FDA Drug Development and Drug Interactions DMPN1TW RU https://www.fda.gov/drugs/developmentapprovalprocess/developmentresources/druginteractionslabeling/ucm093664.htm#table3-2 DMPN1TW DI DMPN1TW DMPN1TW DN Dofetilide DMPN1TW MI DT9IDPW DMPN1TW MN Organic cation transporter 2 (SLC22A2) DMPN1TW MT DTP DMPN1TW MA Substrate DMPN1TW RN FDA Drug Development and Drug Interactions DMPN1TW RU https://www.fda.gov/drugs/developmentapprovalprocess/developmentresources/druginteractionslabeling/ucm093664.htm#table3-2 DMPN1TW DI DMPN1TW DMPN1TW DN Dofetilide DMPN1TW MI TT1VOHK DMPN1TW MN Potassium channel unspecific (KC) DMPN1TW MT DTT DMPN1TW MA Modulator DMPN1TW RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. DMPN1TW RU https://www.fda.gov/ DMMG26Z DI DMMG26Z DMMG26Z DN Dolasetron DMMG26Z MI TTPC4TU DMMG26Z MN 5-HT 3A receptor (HTR3A) DMMG26Z MT DTT DMMG26Z MA Antagonist DMMG26Z RN Palonosetron plus dexamethasone versus granisetron plus dexamethasone for prevention of nausea and vomiting during chemotherapy: a double-blind, do... Lancet Oncol. 2009 Feb;10(2):115-24. DMMG26Z RU https://pubmed.ncbi.nlm.nih.gov/19135415 DMMG26Z DI DMMG26Z DMMG26Z DN Dolasetron DMMG26Z MI DE5IED8 DMMG26Z MN Cytochrome P450 2C9 (CYP2C9) DMMG26Z MT DME DMMG26Z MA Metabolism DMMG26Z RN Summary of information on human CYP enzymes: human P450 metabolism data. Drug Metab Rev. 2002 Feb-May;34(1-2):83-448. DMMG26Z RU https://www.ncbi.nlm.nih.gov/pubmed/?term=11996015 DMMG26Z DI DMMG26Z DMMG26Z DN Dolasetron DMMG26Z MI DECB0K3 DMMG26Z MN Cytochrome P450 2D6 (CYP2D6) DMMG26Z MT DME DMMG26Z MA Metabolism DMMG26Z RN Reappraisal of the role of dolasetron in prevention and treatment of nausea and vomiting associated with surgery or chemotherapy. Cancer Manag Res. 2012;4:67-73. DMMG26Z RU https://www.ncbi.nlm.nih.gov/pubmed/?term=22427733 DMMG26Z DI DMMG26Z DMMG26Z DN Dolasetron DMMG26Z MI DE4LYSA DMMG26Z MN Cytochrome P450 3A4 (CYP3A4) DMMG26Z MT DME DMMG26Z MA Metabolism DMMG26Z RN Characterization of the cytochrome P450 enzymes involved in the in vitro metabolism of dolasetron. Comparison with other indole-containing 5-HT3 antagonists. Drug Metab Dispos. 1996 May;24(5):602-9. DMMG26Z RU https://www.ncbi.nlm.nih.gov/pubmed/?term=8723743 DMCZGRE DI DMCZGRE DMCZGRE DN Dolutegravir DMCZGRE MI DE4LYSA DMCZGRE MN Cytochrome P450 3A4 (CYP3A4) DMCZGRE MT DME DMCZGRE MA Metabolism DMCZGRE RN Mechanisms of action, pharmacology and interactions of dolutegravir. Enferm Infecc Microbiol Clin. 2015 Mar;33 Suppl 1:2-8. DMCZGRE RU https://www.ncbi.nlm.nih.gov/pubmed/?term=25858605 DMCZGRE DI DMCZGRE DMCZGRE DN Dolutegravir DMCZGRE MI TT5FH9Y DMCZGRE MN Human immunodeficiency virus Integrase (HIV IN) DMCZGRE MT DTT DMCZGRE MA Modulator DMCZGRE RN Radium 223 dichloride for prostate cancer treatment. Drug Des Devel Ther. 2017 Sep 6;11:2643-2651. DMCZGRE RU https://pubmed.ncbi.nlm.nih.gov/28919714 DMCZGRE DI DMCZGRE DMCZGRE DN Dolutegravir DMCZGRE MI DTUGYRD DMCZGRE MN P-glycoprotein 1 (ABCB1) DMCZGRE MT DTP DMCZGRE MA Substrate DMCZGRE RN Tarascon Pocket Pharmacopoeia 2018 Classic Shirt-Pocket Edition. DMCZGRE RU https://books.google.com/books?id=0gBRDwAAQBAJ&pg=PP37&lpg=PP37&dq=Methylergonovine+transporter+uptake+efflex&source=bl&ots=cUTe_ppsmZ&sig=ACfU3U3E_YqrDg0CNEuj8K-7lci47HAnrg&hl=zh-CN&sa=X&ved=2ahUKEwjnj-Dk7d7iAhUsK6YKHd5DBDkQ6AEwEnoECAgQAQ#v=onepage&q&f=false DMCZGRE DI DMCZGRE DMCZGRE DN Dolutegravir DMCZGRE MI DEYGVN4 DMCZGRE MN UDP-glucuronosyltransferase 1A1 (UGT1A1) DMCZGRE MT DME DMCZGRE MA Metabolism DMCZGRE RN Mechanisms of action, pharmacology and interactions of dolutegravir. Enferm Infecc Microbiol Clin. 2015 Mar;33 Suppl 1:2-8. DMCZGRE RU https://www.ncbi.nlm.nih.gov/pubmed/?term=25858605 DMBDPY0 DI DMBDPY0 DMBDPY0 DN Domperidone DMBDPY0 MI DEJGDUW DMBDPY0 MN Cytochrome P450 1A2 (CYP1A2) DMBDPY0 MT DME DMBDPY0 MA Metabolism DMBDPY0 RN Characterization of human cytochrome P450 enzymes catalyzing domperidone N-dealkylation and hydroxylation in vitro. Br J Clin Pharmacol. 2004 Sep;58(3):277-87. DMBDPY0 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=15327587 DMBDPY0 DI DMBDPY0 DMBDPY0 DN Domperidone DMBDPY0 MI DEPKLMQ DMBDPY0 MN Cytochrome P450 2B6 (CYP2B6) DMBDPY0 MT DME DMBDPY0 MA Metabolism DMBDPY0 RN Characterization of human cytochrome P450 enzymes catalyzing domperidone N-dealkylation and hydroxylation in vitro. Br J Clin Pharmacol. 2004 Sep;58(3):277-87. DMBDPY0 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=15327587 DMBDPY0 DI DMBDPY0 DMBDPY0 DN Domperidone DMBDPY0 MI DES5XRU DMBDPY0 MN Cytochrome P450 2C8 (CYP2C8) DMBDPY0 MT DME DMBDPY0 MA Metabolism DMBDPY0 RN Characterization of human cytochrome P450 enzymes catalyzing domperidone N-dealkylation and hydroxylation in vitro. Br J Clin Pharmacol. 2004 Sep;58(3):277-87. DMBDPY0 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=15327587 DMBDPY0 DI DMBDPY0 DMBDPY0 DN Domperidone DMBDPY0 MI DECB0K3 DMBDPY0 MN Cytochrome P450 2D6 (CYP2D6) DMBDPY0 MT DME DMBDPY0 MA Metabolism DMBDPY0 RN Characterization of human cytochrome P450 enzymes catalyzing domperidone N-dealkylation and hydroxylation in vitro. Br J Clin Pharmacol. 2004 Sep;58(3):277-87. DMBDPY0 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=15327587 DMBDPY0 DI DMBDPY0 DMBDPY0 DN Domperidone DMBDPY0 MI DE4LYSA DMBDPY0 MN Cytochrome P450 3A4 (CYP3A4) DMBDPY0 MT DME DMBDPY0 MA Metabolism DMBDPY0 RN Characterization of CYP3A isozymes involved in the metabolism of domperidone: role of cytochrome b5 and inhibition by ketoconazole. Drug Metab Lett. 2010 Apr;4(2):95-103. DMBDPY0 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=21281268 DMBDPY0 DI DMBDPY0 DMBDPY0 DN Domperidone DMBDPY0 MI DEIBDNY DMBDPY0 MN Cytochrome P450 3A5 (CYP3A5) DMBDPY0 MT DME DMBDPY0 MA Metabolism DMBDPY0 RN Drug Interactions Flockhart Table DMBDPY0 RU https://drug-interactions.medicine.iu.edu/Main-Table.aspx DMBDPY0 DI DMBDPY0 DMBDPY0 DN Domperidone DMBDPY0 MI DERD86B DMBDPY0 MN Cytochrome P450 3A7 (CYP3A7) DMBDPY0 MT DME DMBDPY0 MA Metabolism DMBDPY0 RN Drug Interactions Flockhart Table DMBDPY0 RU https://drug-interactions.medicine.iu.edu/Main-Table.aspx DMBDPY0 DI DMBDPY0 DMBDPY0 DN Domperidone DMBDPY0 MI TTEX248 DMBDPY0 MN Dopamine D2 receptor (D2R) DMBDPY0 MT DTT DMBDPY0 MA Antagonist DMBDPY0 RN Screening of domperidone in wastewater by high performance liquid chromatography and solid phase extraction methods. Talanta. 2006 Jan 15;68(3):928-31. DMBDPY0 RU https://pubmed.ncbi.nlm.nih.gov/18970411 DMBDPY0 DI DMBDPY0 DMBDPY0 DN Domperidone DMBDPY0 MI DTUGYRD DMBDPY0 MN P-glycoprotein 1 (ABCB1) DMBDPY0 MT DTP DMBDPY0 MA Substrate DMBDPY0 RN Identification of P-glycoprotein substrates and inhibitors among psychoactive compounds--implications for pharmacokinetics of selected substrates. J Pharm Pharmacol. 2004 Aug;56(8):967-75. DMBDPY0 RU http://www.ncbi.nlm.nih.gov/pubmed/15285840 DMIYG7Z DI DMIYG7Z DMIYG7Z DN Donepezil DMIYG7Z MI TT1RS9F DMIYG7Z MN Acetylcholinesterase (AChE) DMIYG7Z MT DTT DMIYG7Z MA Modulator DMIYG7Z RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2465). DMIYG7Z RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2465 DMIYG7Z DI DMIYG7Z DMIYG7Z DN Donepezil DMIYG7Z MI DE5IED8 DMIYG7Z MN Cytochrome P450 2C9 (CYP2C9) DMIYG7Z MT DME DMIYG7Z MA Metabolism DMIYG7Z RN Stereoselective metabolism of donepezil and steady-state plasma concentrations of S-donepezil based on CYP2D6 polymorphisms in the therapeutic responses of Han Chinese patients with Alzheimer's disease. J Pharmacol Sci. 2015 Nov;129(3):188-95. DMIYG7Z RU https://www.ncbi.nlm.nih.gov/pubmed/?term=26603528 DMIYG7Z DI DMIYG7Z DMIYG7Z DN Donepezil DMIYG7Z MI DECB0K3 DMIYG7Z MN Cytochrome P450 2D6 (CYP2D6) DMIYG7Z MT DME DMIYG7Z MA Metabolism DMIYG7Z RN Donepezil plasma concentrations, CYP2D6 and CYP3A4 phenotypes, and cognitive outcome in Alzheimer's disease. Eur J Clin Pharmacol. 2016 Jun;72(6):711-7. DMIYG7Z RU https://www.ncbi.nlm.nih.gov/pubmed/?term=26952092 DMIYG7Z DI DMIYG7Z DMIYG7Z DN Donepezil DMIYG7Z MI DE4LYSA DMIYG7Z MN Cytochrome P450 3A4 (CYP3A4) DMIYG7Z MT DME DMIYG7Z MA Metabolism DMIYG7Z RN Donepezil plasma concentrations, CYP2D6 and CYP3A4 phenotypes, and cognitive outcome in Alzheimer's disease. Eur J Clin Pharmacol. 2016 Jun;72(6):711-7. DMIYG7Z RU https://www.ncbi.nlm.nih.gov/pubmed/?term=26952092 DMPGUCF DI DMPGUCF DMPGUCF DN Dopamine DMPGUCF MI DEV3T4A DMPGUCF MN Catechol O-methyltransferase (COMT) DMPGUCF MT DME DMPGUCF MA Metabolism DMPGUCF RN Association between polymorphisms in catechol-O-methyltransferase (COMT) and cocaine-induced paranoia in European-American and African-American populations. Am J Med Genet B Neuropsychiatr Genet. 2011 Sep;156B(6):651-60. DMPGUCF RU https://www.ncbi.nlm.nih.gov/pubmed/?term=21656904 DMPGUCF DI DMPGUCF DMPGUCF DN Dopamine DMPGUCF MI DEJGDUW DMPGUCF MN Cytochrome P450 1A2 (CYP1A2) DMPGUCF MT DME DMPGUCF MA Metabolism DMPGUCF RN Modulation of CYP1A2 enzyme activity by indoleamines: inhibition by serotonin and tryptamine. Pharmacogenetics. 1998 Jun;8(3):251-8. DMPGUCF RU https://www.ncbi.nlm.nih.gov/pubmed/?term=9682270 DMPGUCF DI DMPGUCF DMPGUCF DN Dopamine DMPGUCF MI DE5IED8 DMPGUCF MN Cytochrome P450 2C9 (CYP2C9) DMPGUCF MT DME DMPGUCF MA Metabolism DMPGUCF RN Pharmacogenetics of schizophrenia. Am J Med Genet. 2000 Spring;97(1):98-106. DMPGUCF RU https://www.ncbi.nlm.nih.gov/pubmed/?term=10813809 DMPGUCF DI DMPGUCF DMPGUCF DN Dopamine DMPGUCF MI DECB0K3 DMPGUCF MN Cytochrome P450 2D6 (CYP2D6) DMPGUCF MT DME DMPGUCF MA Metabolism DMPGUCF RN Pharmacogenetics of schizophrenia. Am J Med Genet. 2000 Spring;97(1):98-106. DMPGUCF RU https://www.ncbi.nlm.nih.gov/pubmed/?term=10813809 DMPGUCF DI DMPGUCF DMPGUCF DN Dopamine DMPGUCF MI TTEX248 DMPGUCF MN Dopamine D2 receptor (D2R) DMPGUCF MT DTT DMPGUCF MA Agonist DMPGUCF RN The Detection of Dopamine Gene Receptors (DRD1-DRD5) Expression on Human Peripheral Blood Lymphocytes by Real Time PCR. Iran J Allergy Asthma Immunol. 2004 Dec;3(4):169-74. DMPGUCF RU https://pubmed.ncbi.nlm.nih.gov/17301410 DMPGUCF DI DMPGUCF DMPGUCF DN Dopamine DMPGUCF MI DEL0D64 DMPGUCF MN Dopamine dehydroxylase (dadH) DMPGUCF MT DME DMPGUCF MA Metabolism DMPGUCF RN Discovery and inhibition of an interspecies gut bacterial pathway for Levodopa metabolism. Science. 2019 Jun 14;364(6445). pii: eaau6323. DMPGUCF RU https://pubmed.ncbi.nlm.nih.gov/31196984 DMPGUCF DI DMPGUCF DMPGUCF DN Dopamine DMPGUCF MI DEGTFWK DMPGUCF MN Mephenytoin 4-hydroxylase (CYP2C19) DMPGUCF MT DME DMPGUCF MA Metabolism DMPGUCF RN Pharmacogenetics of schizophrenia. Am J Med Genet. 2000 Spring;97(1):98-106. DMPGUCF RU https://www.ncbi.nlm.nih.gov/pubmed/?term=10813809 DMPGUCF DI DMPGUCF DMPGUCF DN Dopamine DMPGUCF MI DET2NXO DMPGUCF MN Monoamine oxidase type B (MAO-B) DMPGUCF MT DME DMPGUCF MA Metabolism DMPGUCF RN Monoamine oxidases (MAO) in the pathogenesis of heart failure and ischemia/reperfusion injury. Biochim Biophys Acta. 2011 Jul;1813(7):1323-32. DMPGUCF RU https://www.ncbi.nlm.nih.gov/pubmed/?term=20869994 DMPGUCF DI DMPGUCF DMPGUCF DN Dopamine DMPGUCF MI DTT79CX DMPGUCF MN Organic cation transporter 1 (SLC22A1) DMPGUCF MT DTP DMPGUCF MA Substrate DMPGUCF RN Organic cation transporters and their pharmacokinetic and pharmacodynamic consequences. Drug Metab Pharmacokinet. 2008;23(4):243-53. DMPGUCF RU https://doi.org/10.2133/dmpk.23.243 DMPGUCF DI DMPGUCF DMPGUCF DN Dopamine DMPGUCF MI DT9IDPW DMPGUCF MN Organic cation transporter 2 (SLC22A2) DMPGUCF MT DTP DMPGUCF MA Substrate DMPGUCF RN Differential pharmacological in vitro properties of organic cation transporters and regional distribution in rat brain. Neuropharmacology. 2006 Jun;50(8):941-52. DMPGUCF RU http://www.ncbi.nlm.nih.gov/pubmed/16581093 DMPGUCF DI DMPGUCF DMPGUCF DN Dopamine DMPGUCF MI DT3BA8L DMPGUCF MN Sodium-dependent dopamine transporter (SLC6A3) DMPGUCF MT DTP DMPGUCF MA Substrate DMPGUCF RN Characterization of VNTRs Within the Entire Region of SLC6A3 and Its Association with Hypertension. DNA Cell Biol. 2017 Mar;36(3):227-236. DMPGUCF RU http://www.ncbi.nlm.nih.gov/pubmed/28055236 DMPGUCF DI DMPGUCF DMPGUCF DN Dopamine DMPGUCF MI DED5UR3 DMPGUCF MN Sulfotransferase 1B1 (SULT1B1) DMPGUCF MT DME DMPGUCF MA Metabolism DMPGUCF RN Molecular cloning, expression, and functional characterization of novel mouse sulfotransferases. Biochem Biophys Res Commun. 1998 Jun 29;247(3):681-6. DMPGUCF RU https://www.ncbi.nlm.nih.gov/pubmed/?term=9647753 DMPGUCF DI DMPGUCF DMPGUCF DN Dopamine DMPGUCF MI DT7A9GF DMPGUCF MN Synaptic vesicle glycoprotein 2C (SLC22B3) DMPGUCF MT DTP DMPGUCF MA Substrate DMPGUCF RN Synaptic vesicle glycoprotein 2C (SV2C) modulates dopamine release and is disrupted in Parkinson disease. Proc Natl Acad Sci U S A. 2017 Mar 14;114(11):E2253-E2262. DMPGUCF RU http://www.ncbi.nlm.nih.gov/pubmed/28246328 DMPGUCF DI DMPGUCF DMPGUCF DN Dopamine DMPGUCF MI DTM953D DMPGUCF MN Vesicular amine transporter 1 (SLC18A1) DMPGUCF MT DTP DMPGUCF MA Substrate DMPGUCF RN SLC18: Vesicular neurotransmitter transporters for monoamines and acetylcholine. Mol Aspects Med. 2013 Apr-Jun;34(2-3):360-72. DMPGUCF RU http://www.ncbi.nlm.nih.gov/pubmed/23506877 DMPGUCF DI DMPGUCF DMPGUCF DN Dopamine DMPGUCF MI DTT7VPB DMPGUCF MN Vesicular amine transporter 2 (SLC18A2) DMPGUCF MT DTP DMPGUCF MA Substrate DMPGUCF RN SLC18: Vesicular neurotransmitter transporters for monoamines and acetylcholine. Mol Aspects Med. 2013 Apr-Jun;34(2-3):360-72. DMPGUCF RU http://www.ncbi.nlm.nih.gov/pubmed/23506877 DMSCIKZ DI DMSCIKZ DMSCIKZ DN Dopexamine DMSCIKZ MI TTEX248 DMSCIKZ MN Dopamine D2 receptor (D2R) DMSCIKZ MT DTT DMSCIKZ MA Modulator DMSCIKZ RN Natural products as sources of new drugs over the last 25 years. J Nat Prod. 2007 Mar;70(3):461-77. DMSCIKZ RU https://pubmed.ncbi.nlm.nih.gov/17309302 DM9UCJK DI DM9UCJK DM9UCJK DN Doripenem DM9UCJK MI TT4ILYC DM9UCJK MN Bacterial Dihydropteroate synthetase (Bact folP) DM9UCJK MT DTT DM9UCJK MA Inhibitor DM9UCJK RN Emerging drugs for bacterial urinary tract infections. Expert Opin Emerg Drugs. 2005 May;10(2):275-98. DM9UCJK RU https://pubmed.ncbi.nlm.nih.gov/15934867 DM9UCJK DI DM9UCJK DM9UCJK DN Doripenem DM9UCJK MI DEC3G7M DM9UCJK MN Beta-lactamase (blaB) DM9UCJK MT DME DM9UCJK MA Metabolism DM9UCJK RN FRI-4 carbapenemase-producing Enterobacter cloacae complex isolated in Tokyo, Japan. J Antimicrob Chemother. 2018 Nov 1;73(11):2969-2972. DM9UCJK RU https://pubmed.ncbi.nlm.nih.gov/30060114 DM9UCJK DI DM9UCJK DM9UCJK DN Doripenem DM9UCJK MI DEAMVR3 DM9UCJK MN Dehydropeptidase-I (DPEP1) DM9UCJK MT DME DM9UCJK MA Metabolism DM9UCJK RN Disposition, metabolism, and excretion of [14C]doripenem after a single 500-milligram intravenous infusion in healthy men. Antimicrob Agents Chemother. 2008 Oct;52(10):3478-83. DM9UCJK RU https://www.ncbi.nlm.nih.gov/pubmed/?term=18644951 DM3XU74 DI DM3XU74 DM3XU74 DN Dornase Alfa DM3XU74 MI TTUTN1I DM3XU74 MN Human Deoxyribonucleic acid (hDNA) DM3XU74 MT DTT DM3XU74 MA Breaker DM3XU74 RN Dornase alfa. BioDrugs. 1997 Dec;8(6):439-45. DM3XU74 RU https://pubmed.ncbi.nlm.nih.gov/18031106 DMA17D0 DI DMA17D0 DMA17D0 DN Dorzolamide DMA17D0 MI TTANPDJ DMA17D0 MN Carbonic anhydrase II (CA-II) DMA17D0 MT DTT DMA17D0 MA Inhibitor DMA17D0 RN Carbonic anhydrase inhibitors. Inhibition studies of a coral secretory isoform by sulfonamides. Bioorg Med Chem. 2009 Jul 15;17(14):5054-8. DMA17D0 RU https://pubmed.ncbi.nlm.nih.gov/19520577 DMA17D0 DI DMA17D0 DMA17D0 DN Dorzolamide DMA17D0 MI DE5IED8 DMA17D0 MN Cytochrome P450 2C9 (CYP2C9) DMA17D0 MT DME DMA17D0 MA Metabolism DMA17D0 RN Summary of information on human CYP enzymes: human P450 metabolism data. Drug Metab Rev. 2002 Feb-May;34(1-2):83-448. DMA17D0 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=11996015 DMA17D0 DI DMA17D0 DMA17D0 DN Dorzolamide DMA17D0 MI DEVDYN7 DMA17D0 MN Cytochrome P450 2E1 (CYP2E1) DMA17D0 MT DME DMA17D0 MA Metabolism DMA17D0 RN In vitro metabolism of dorzolamide, a novel potent carbonic anhydrase inhibitor, in rat liver microsomes. Drug Metab Dispos. 1994 Nov-Dec;22(6):916-21. DMA17D0 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=7895610 DMA17D0 DI DMA17D0 DMA17D0 DN Dorzolamide DMA17D0 MI DE4LYSA DMA17D0 MN Cytochrome P450 3A4 (CYP3A4) DMA17D0 MT DME DMA17D0 MA Metabolism DMA17D0 RN Summary of information on human CYP enzymes: human P450 metabolism data. Drug Metab Rev. 2002 Feb-May;34(1-2):83-448. DMA17D0 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=11996015 DM78NWP DI DM78NWP DM78NWP DN Dostarlimab DM78NWP MI TTNBFWK DM78NWP MN Programmed cell death protein 1 (PD-1) DM78NWP MT DTT DM78NWP MA Inhibitor DM78NWP RN Dostarlimab in the treatment of recurrent or primary advanced endometrial cancer. Future Oncol. 2021 Mar;17(8):877-892. DM78NWP RU https://pubmed.ncbi.nlm.nih.gov/33251877 DMKE7L9 DI DMKE7L9 DMKE7L9 DN Doxacurium DMKE7L9 MI TTS5WZF DMKE7L9 MN Neuronal acetylcholine receptor alpha (NACHRA) DMKE7L9 MT DTT DMKE7L9 MA Antagonist DMKE7L9 RN Interaction of nondepolarizing muscle relaxants with M2 and M3 muscarinic receptors in guinea pig lung and heart. Anesthesiology. 1996 Jan;84(1):155-61. DMKE7L9 RU https://pubmed.ncbi.nlm.nih.gov/8572329 DMCYANK DI DMCYANK DMCYANK DN Doxapram DMCYANK MI DE4LYSA DMCYANK MN Cytochrome P450 3A4 (CYP3A4) DMCYANK MT DME DMCYANK MA Metabolism DMCYANK RN Population pharmacokinetics of doxapram in low-birth-weight Japanese infants with apnea. Eur J Pediatr. 2015 Apr;174(4):509-18. DMCYANK RU https://www.ncbi.nlm.nih.gov/pubmed/?term=25248340 DMCYANK DI DMCYANK DMCYANK DN Doxapram DMCYANK MI DEIBDNY DMCYANK MN Cytochrome P450 3A5 (CYP3A5) DMCYANK MT DME DMCYANK MA Metabolism DMCYANK RN Population pharmacokinetics of doxapram in low-birth-weight Japanese infants with apnea. Eur J Pediatr. 2015 Apr;174(4):509-18. DMCYANK RU https://www.ncbi.nlm.nih.gov/pubmed/?term=25248340 DMCYANK DI DMCYANK DMCYANK DN Doxapram DMCYANK MI TT6EYVN DMCYANK MN Peripheral carotid chemoreceptor (PCC) DMCYANK MT DTT DMCYANK MA Stimulator DMCYANK RN Ovalbumin sensitization alters the ventilatory responses to chemical challenges in guinea pigs. J Appl Physiol (1985). 2005 Nov;99(5):1782-8. DMCYANK RU https://pubmed.ncbi.nlm.nih.gov/16024517 DM9PLRH DI DM9PLRH DM9PLRH DN Doxazosin DM9PLRH MI TT34BHT DM9PLRH MN Adrenergic receptor alpha-1D (ADRA1D) DM9PLRH MT DTT DM9PLRH MA Antagonist DM9PLRH RN The role of combination medical therapy in benign prostatic hyperplasia. Int J Impot Res. 2008 Dec;20 Suppl 3:S33-43. DM9PLRH RU https://pubmed.ncbi.nlm.nih.gov/19002123 DM9PLRH DI DM9PLRH DM9PLRH DN Doxazosin DM9PLRH MI DE5IED8 DM9PLRH MN Cytochrome P450 2C9 (CYP2C9) DM9PLRH MT DME DM9PLRH MA Metabolism DM9PLRH RN Product monograph: CARDURA (Doxazosin mesylate). DM9PLRH RU https://www.pfizer.ca/sites/g/files/g10050796/f/201710/CARDURA_PM_Eng_201486_4Apr2017.pdf DM9PLRH DI DM9PLRH DM9PLRH DN Doxazosin DM9PLRH MI DECB0K3 DM9PLRH MN Cytochrome P450 2D6 (CYP2D6) DM9PLRH MT DME DM9PLRH MA Metabolism DM9PLRH RN Priapism induced by boceprevir-CYP3A4 inhibition and alpha-adrenergic blockade: case report. Clin Infect Dis. 2014 Jan;58(1):e35-8. DM9PLRH RU https://www.ncbi.nlm.nih.gov/pubmed/?term=24092799 DM9PLRH DI DM9PLRH DM9PLRH DN Doxazosin DM9PLRH MI DE4LYSA DM9PLRH MN Cytochrome P450 3A4 (CYP3A4) DM9PLRH MT DME DM9PLRH MA Metabolism DM9PLRH RN Priapism induced by boceprevir-CYP3A4 inhibition and alpha-adrenergic blockade: case report. Clin Infect Dis. 2014 Jan;58(1):e35-8. DM9PLRH RU https://www.ncbi.nlm.nih.gov/pubmed/?term=24092799 DM9PLRH DI DM9PLRH DM9PLRH DN Doxazosin DM9PLRH MI DEGTFWK DM9PLRH MN Mephenytoin 4-hydroxylase (CYP2C19) DM9PLRH MT DME DM9PLRH MA Metabolism DM9PLRH RN Priapism induced by boceprevir-CYP3A4 inhibition and alpha-adrenergic blockade: case report. Clin Infect Dis. 2014 Jan;58(1):e35-8. DM9PLRH RU https://www.ncbi.nlm.nih.gov/pubmed/?term=24092799 DMPI98T DI DMPI98T DMPI98T DN Doxepin DMPI98T MI DEJGDUW DMPI98T MN Cytochrome P450 1A2 (CYP1A2) DMPI98T MT DME DMPI98T MA Metabolism DMPI98T RN The N-demethylation of the doxepin isomers is mainly catalyzed by the polymorphic CYP2C19. Pharm Res. 2002 Jul;19(7):1034-7. DMPI98T RU https://www.ncbi.nlm.nih.gov/pubmed/?term=12180536 DMPI98T DI DMPI98T DMPI98T DN Doxepin DMPI98T MI DE5IED8 DMPI98T MN Cytochrome P450 2C9 (CYP2C9) DMPI98T MT DME DMPI98T MA Metabolism DMPI98T RN Contributions of CYP2D6, CYP2C9 and CYP2C19 to the biotransformation of E- and Z-doxepin in healthy volunteers. Pharmacogenetics. 2002 Oct;12(7):571-80. DMPI98T RU https://www.ncbi.nlm.nih.gov/pubmed/?term=12360109 DMPI98T DI DMPI98T DMPI98T DN Doxepin DMPI98T MI DECB0K3 DMPI98T MN Cytochrome P450 2D6 (CYP2D6) DMPI98T MT DME DMPI98T MA Metabolism DMPI98T RN Doxepin inhibits CYP2D6 activity in vivo. Pol J Pharmacol. 2004 Jul-Aug;56(4):491-4. DMPI98T RU https://www.ncbi.nlm.nih.gov/pubmed/?term=15520506 DMPI98T DI DMPI98T DMPI98T DN Doxepin DMPI98T MI DE4LYSA DMPI98T MN Cytochrome P450 3A4 (CYP3A4) DMPI98T MT DME DMPI98T MA Metabolism DMPI98T RN The N-demethylation of the doxepin isomers is mainly catalyzed by the polymorphic CYP2C19. Pharm Res. 2002 Jul;19(7):1034-7. DMPI98T RU https://www.ncbi.nlm.nih.gov/pubmed/?term=12180536 DMPI98T DI DMPI98T DMPI98T DN Doxepin DMPI98T MI TTTIBOJ DMPI98T MN Histamine H1 receptor (H1R) DMPI98T MT DTT DMPI98T MA Inhibitor DMPI98T RN Novel therapeutic usage of low-dose doxepin hydrochloride. Expert Opin Investig Drugs. 2007 Aug;16(8):1295-305. DMPI98T RU https://pubmed.ncbi.nlm.nih.gov/17685877 DMPI98T DI DMPI98T DMPI98T DN Doxepin DMPI98T MI DEGTFWK DMPI98T MN Mephenytoin 4-hydroxylase (CYP2C19) DMPI98T MT DME DMPI98T MA Metabolism DMPI98T RN Contributions of CYP2D6, CYP2C9 and CYP2C19 to the biotransformation of E- and Z-doxepin in healthy volunteers. Pharmacogenetics. 2002 Oct;12(7):571-80. DMPI98T RU https://www.ncbi.nlm.nih.gov/pubmed/?term=12360109 DM6FG1P DI DM6FG1P DM6FG1P DN Doxercalciferol DM6FG1P MI DEBS639 DM6FG1P MN Vitamin D(3) 25-hydroxylase (CYP27A1) DM6FG1P MT DME DM6FG1P MA Metabolism DM6FG1P RN Efficacy and safety of oral doxercalciferol in the management of secondary hyperparathyroidism in chronic kidney disease stage 4. Indian J Nephrol. 2013 Jul;23(4):271-5. DM6FG1P RU https://www.ncbi.nlm.nih.gov/pubmed/?term=23960343 DM6FG1P DI DM6FG1P DM6FG1P DN Doxercalciferol DM6FG1P MI TTK59TV DM6FG1P MN Vitamin D3 receptor (VDR) DM6FG1P MT DTT DM6FG1P MA Antagonist DM6FG1P RN Emerging drugs for psoriasis. Expert Opin Emerg Drugs. 2009 Mar;14(1):145-63. DM6FG1P RU https://pubmed.ncbi.nlm.nih.gov/19249988 DMEDKZH DI DMEDKZH DMEDKZH DN Doxofylline DMEDKZH MI DEJGDUW DMEDKZH MN Cytochrome P450 1A2 (CYP1A2) DMEDKZH MT DME DMEDKZH MA Metabolism DMEDKZH RN PharmGKB summary: caffeine pathway. Pharmacogenet Genomics. 2012 May;22(5):389-95. DMEDKZH RU https://www.ncbi.nlm.nih.gov/pubmed/?term=22293536 DMVP5YE DI DMVP5YE DMVP5YE DN Doxorubicin DMVP5YE MI DED2FW3 DMVP5YE MN Aldo-keto reductase 1A1 (AKR1A1) DMVP5YE MT DME DMVP5YE MA Metabolism DMVP5YE RN Carbonyl reductase 1 is a predominant doxorubicin reductase in the human liver. Drug Metab Dispos. 2008 Oct;36(10):2113-20. DMVP5YE RU https://www.ncbi.nlm.nih.gov/pubmed/?term=18635746 DMVP5YE DI DMVP5YE DMVP5YE DN Doxorubicin DMVP5YE MI DEGQTXO DMVP5YE MN Aldo-keto reductase 1C3 (AKR1C3) DMVP5YE MT DME DMVP5YE MA Metabolism DMVP5YE RN Inactivation of the anticancer drugs doxorubicin and oracin by aldo-keto reductase (AKR) 1C3. Toxicol Lett. 2008 Sep;181(1):1-6. DMVP5YE RU https://www.ncbi.nlm.nih.gov/pubmed/?term=18616992 DMVP5YE DI DMVP5YE DMVP5YE DN Doxorubicin DMVP5YE MI DTKVEXO DMVP5YE MN ATP-binding cassette sub-family B member 5 (ABCB5) DMVP5YE MT DTP DMVP5YE MA Substrate DMVP5YE RN ABCB5-mediated doxorubicin transport and chemoresistance in human malignant melanoma. Cancer Res. 2005 May 15;65(10):4320-33. DMVP5YE RU http://www.ncbi.nlm.nih.gov/pubmed/15899824 DMVP5YE DI DMVP5YE DMVP5YE DN Doxorubicin DMVP5YE MI DT0KQND DMVP5YE MN ATP-binding cassette sub-family B member 8 (ABCB8) DMVP5YE MT DTP DMVP5YE MA Substrate DMVP5YE RN ABCB8 mediates doxorubicin resistance in melanoma cells by protecting the mitochondrial genome. Mol Cancer Res. 2009 Jan;7(1):79-87. DMVP5YE RU http://www.ncbi.nlm.nih.gov/pubmed/19147539 DMVP5YE DI DMVP5YE DMVP5YE DN Doxorubicin DMVP5YE MI DTI7UX6 DMVP5YE MN Breast cancer resistance protein (ABCG2) DMVP5YE MT DTP DMVP5YE MA Substrate DMVP5YE RN Doxorubicin transport by RALBP1 and ABCG2 in lung and breast cancer. Int J Oncol. 2007 Mar;30(3):717-25. DMVP5YE RU http://www.ncbi.nlm.nih.gov/pubmed/17273774 DMVP5YE DI DMVP5YE DMVP5YE DN Doxorubicin DMVP5YE MI DECB0K3 DMVP5YE MN Cytochrome P450 2D6 (CYP2D6) DMVP5YE MT DME DMVP5YE MA Metabolism DMVP5YE RN Inhibitory effects of anticancer drugs on dextromethorphan-O-demethylase activity in human liver microsomes. Cancer Chemother Pharmacol. 1993;32(6):491-5. DMVP5YE RU https://www.ncbi.nlm.nih.gov/pubmed/?term=8258200 DMVP5YE DI DMVP5YE DMVP5YE DN Doxorubicin DMVP5YE MI DE4LYSA DMVP5YE MN Cytochrome P450 3A4 (CYP3A4) DMVP5YE MT DME DMVP5YE MA Metabolism DMVP5YE RN Expression levels and activation of a PXR variant are directly related to drug resistance in osteosarcoma cell lines. Cancer. 2007 Mar 1;109(5):957-65. DMVP5YE RU https://www.ncbi.nlm.nih.gov/pubmed/?term=17279585 DMVP5YE DI DMVP5YE DMVP5YE DN Doxorubicin DMVP5YE MI DEIBDNY DMVP5YE MN Cytochrome P450 3A5 (CYP3A5) DMVP5YE MT DME DMVP5YE MA Metabolism DMVP5YE RN Drug related genetic polymorphisms affecting adverse reactions to methotrexate, vinblastine, doxorubicin and cisplatin in patients with urothelial cancer. J Urol. 2008 Dec;180(6):2389-95. DMVP5YE RU https://www.ncbi.nlm.nih.gov/pubmed/?term=18930278 DMVP5YE DI DMVP5YE DMVP5YE DN Doxorubicin DMVP5YE MI TT0IHXV DMVP5YE MN DNA topoisomerase II (TOP2) DMVP5YE MT DTT DMVP5YE MA Modulator DMVP5YE RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. DMVP5YE RU https://www.fda.gov/ DMVP5YE DI DMVP5YE DMVP5YE DN Doxorubicin DMVP5YE MI DTPATLS DMVP5YE MN Fly-like putative transporter 2 (SLC22A16) DMVP5YE MT DTP DMVP5YE MA Substrate DMVP5YE RN Influence of pharmacogenetics on response and toxicity in breast cancer patients treated with doxorubicin and cyclophosphamide. Br J Cancer. 2010 Mar 16;102(6):1003-9. DMVP5YE RU http://www.ncbi.nlm.nih.gov/pubmed/20179710 DMVP5YE DI DMVP5YE DMVP5YE DN Doxorubicin DMVP5YE MI DE6NIY9 DMVP5YE MN Methionine synthase reductase (MTRR) DMVP5YE MT DME DMVP5YE MA Metabolism DMVP5YE RN Differences in the efficiency of reductive activation of methionine synthase and exogenous electron acceptors between the common polymorphic variants of human methionine synthase reductase. Biochemistry. 2002 Nov 12;41(45):13378-85. DMVP5YE RU https://www.ncbi.nlm.nih.gov/pubmed/?term=12416982 DMVP5YE DI DMVP5YE DMVP5YE DN Doxorubicin DMVP5YE MI DEYSOD0 DMVP5YE MN Molybdopterin-dependent enzyme (molD) DMVP5YE MT DME DMVP5YE MA Metabolism DMVP5YE RN Transformation of the anticancer drug doxorubicin in the human gut microbiome. ACS Infect Dis. 2018 Jan 12;4(1):68-76. DMVP5YE RU https://pubmed.ncbi.nlm.nih.gov/29160065 DMVP5YE DI DMVP5YE DMVP5YE DN Doxorubicin DMVP5YE MI DE1QMDG DMVP5YE MN Molybdopterin-dependent enzyme (molD) DMVP5YE MT DME DMVP5YE MA Metabolism DMVP5YE RN Transformation of the anticancer drug doxorubicin in the human gut microbiome. ACS Infect Dis. 2018 Jan 12;4(1):68-76. DMVP5YE RU https://pubmed.ncbi.nlm.nih.gov/29160065 DMVP5YE DI DMVP5YE DMVP5YE DN Doxorubicin DMVP5YE MI DEME01W DMVP5YE MN Molybdopterin-dependent enzyme (molD) DMVP5YE MT DME DMVP5YE MA Metabolism DMVP5YE RN Transformation of the anticancer drug doxorubicin in the human gut microbiome. ACS Infect Dis. 2018 Jan 12;4(1):68-76. DMVP5YE RU https://pubmed.ncbi.nlm.nih.gov/29160065 DMVP5YE DI DMVP5YE DMVP5YE DN Doxorubicin DMVP5YE MI DT342ZG DMVP5YE MN Monocarboxylate transporter 1 (SLC16A1) DMVP5YE MT DTP DMVP5YE MA Substrate DMVP5YE RN Circadian rhythms in gene expression: Relationship to physiology, disease, drug disposition and drug action. Adv Drug Deliv Rev. 2010 Jul 31;62(9-10):904-17. DMVP5YE RU https://doi.org/10.1016/j.addr.2010.05.009 DMVP5YE DI DMVP5YE DMVP5YE DN Doxorubicin DMVP5YE MI DTSYQGK DMVP5YE MN Multidrug resistance-associated protein 1 (ABCC1) DMVP5YE MT DTP DMVP5YE MA Substrate DMVP5YE RN The role of bioreductive activation of doxorubicin in cytotoxic activity against leukaemia HL60-sensitive cell line and its multidrug-resistant sublines. Br J Cancer. 2005 Jul 11;93(1):89-97. DMVP5YE RU http://www.ncbi.nlm.nih.gov/pubmed/15942634 DMVP5YE DI DMVP5YE DMVP5YE DN Doxorubicin DMVP5YE MI DTFI42L DMVP5YE MN Multidrug resistance-associated protein 2 (ABCC2) DMVP5YE MT DTP DMVP5YE MA Substrate DMVP5YE RN Involvement of the drug transporters p glycoprotein and multidrug resistance-associated protein Mrp2 in telithromycin transport. Antimicrob Agents Chemother. 2006 Jan;50(1):80-7. DMVP5YE RU http://www.ncbi.nlm.nih.gov/pubmed/16377671 DMVP5YE DI DMVP5YE DMVP5YE DN Doxorubicin DMVP5YE MI DEAMEF2 DMVP5YE MN NADH dehydrogenase (nuoE) DMVP5YE MT DME DMVP5YE MA Metabolism DMVP5YE RN Bacterial inactivation of the anticancer drug doxorubicin. Chem Biol. 2012 Oct 26;19(10):1255-64. DMVP5YE RU https://pubmed.ncbi.nlm.nih.gov/23102220 DMVP5YE DI DMVP5YE DMVP5YE DN Doxorubicin DMVP5YE MI DEIW03B DMVP5YE MN NADH-ubiquinone oxidoreductase 20 kDa (NDUFS7) DMVP5YE MT DME DMVP5YE MA Metabolism DMVP5YE RN Differential ability of cytostatics from anthraquinone group to generate free radicals in three enzymatic systems: NADH dehydrogenase, NADPH cytochrome P450 reductase, and xanthine oxidase. Oncol Res. 2003;13(5):245-52. DMVP5YE RU https://www.ncbi.nlm.nih.gov/pubmed/?term=12688675 DMVP5YE DI DMVP5YE DMVP5YE DN Doxorubicin DMVP5YE MI DE741FI DMVP5YE MN NADH-ubiquinone oxidoreductase 30 kDa (NDUFS3) DMVP5YE MT DME DMVP5YE MA Metabolism DMVP5YE RN Differential ability of cytostatics from anthraquinone group to generate free radicals in three enzymatic systems: NADH dehydrogenase, NADPH cytochrome P450 reductase, and xanthine oxidase. Oncol Res. 2003;13(5):245-52. DMVP5YE RU https://www.ncbi.nlm.nih.gov/pubmed/?term=12688675 DMVP5YE DI DMVP5YE DMVP5YE DN Doxorubicin DMVP5YE MI DEKX5CD DMVP5YE MN NADH-ubiquinone oxidoreductase 49 kDa (NDUFS2) DMVP5YE MT DME DMVP5YE MA Metabolism DMVP5YE RN Differential ability of cytostatics from anthraquinone group to generate free radicals in three enzymatic systems: NADH dehydrogenase, NADPH cytochrome P450 reductase, and xanthine oxidase. Oncol Res. 2003;13(5):245-52. DMVP5YE RU https://www.ncbi.nlm.nih.gov/pubmed/?term=12688675 DMVP5YE DI DMVP5YE DMVP5YE DN Doxorubicin DMVP5YE MI DE3N2FM DMVP5YE MN NADPH-cytochrome P450 reductase (CPR) DMVP5YE MT DME DMVP5YE MA Metabolism DMVP5YE RN Kinetics of anthracycline antibiotic free radical formation and reductive glycosidase activity. Arch Biochem Biophys. 1983 May;223(1):68-75. DMVP5YE RU https://www.ncbi.nlm.nih.gov/pubmed/?term=6305277 DMVP5YE DI DMVP5YE DMVP5YE DN Doxorubicin DMVP5YE MI DEYEK78 DMVP5YE MN Nitric oxide synthase brain (NOS1) DMVP5YE MT DME DMVP5YE MA Metabolism DMVP5YE RN The role of nitric oxide in anthracycline toxicity and prospects for pharmacologic prevention of cardiac damage. FASEB J. 2004 Apr;18(6):664-75. DMVP5YE RU https://www.ncbi.nlm.nih.gov/pubmed/?term=15054088 DMVP5YE DI DMVP5YE DMVP5YE DN Doxorubicin DMVP5YE MI DE708H2 DMVP5YE MN Nitric oxide synthase endothelial (NOS3) DMVP5YE MT DME DMVP5YE MA Metabolism DMVP5YE RN The role of nitric oxide in anthracycline toxicity and prospects for pharmacologic prevention of cardiac damage. FASEB J. 2004 Apr;18(6):664-75. DMVP5YE RU https://www.ncbi.nlm.nih.gov/pubmed/?term=15054088 DMVP5YE DI DMVP5YE DMVP5YE DN Doxorubicin DMVP5YE MI DE3C1JY DMVP5YE MN Nitric oxide synthase inducible (NOS2) DMVP5YE MT DME DMVP5YE MA Metabolism DMVP5YE RN The role of nitric oxide in anthracycline toxicity and prospects for pharmacologic prevention of cardiac damage. FASEB J. 2004 Apr;18(6):664-75. DMVP5YE RU https://www.ncbi.nlm.nih.gov/pubmed/?term=15054088 DMVP5YE DI DMVP5YE DMVP5YE DN Doxorubicin DMVP5YE MI DTUGYRD DMVP5YE MN P-glycoprotein 1 (ABCB1) DMVP5YE MT DTP DMVP5YE MA Substrate DMVP5YE RN MDR1 (ABCB1) G1199A (Ser400Asn) polymorphism alters transepithelial permeability and sensitivity to anticancer agents. Cancer Chemother Pharmacol. 2009 Jun;64(1):183-8. DMVP5YE RU http://www.ncbi.nlm.nih.gov/pubmed/19123050 DMVP5YE DI DMVP5YE DMVP5YE DN Doxorubicin DMVP5YE MI DENP5RY DMVP5YE MN Quinone reductase 1 (NQO1) DMVP5YE MT DME DMVP5YE MA Metabolism DMVP5YE RN Differential ability of cytostatics from anthraquinone group to generate free radicals in three enzymatic systems: NADH dehydrogenase, NADPH cytochrome P450 reductase, and xanthine oxidase. Oncol Res. 2003;13(5):245-52. DMVP5YE RU https://www.ncbi.nlm.nih.gov/pubmed/?term=12688675 DMVP5YE DI DMVP5YE DMVP5YE DN Doxorubicin DMVP5YE MI DE4G629 DMVP5YE MN Succinic semialdehyde reductase (AKR7A2) DMVP5YE MT DME DMVP5YE MA Metabolism DMVP5YE RN Naturally occurring variants of human aldo-keto reductases with reduced in vitro metabolism of daunorubicin and doxorubicin. J Pharmacol Exp Ther. 2010 Dec;335(3):533-45. DMVP5YE RU https://www.ncbi.nlm.nih.gov/pubmed/?term=20837989 DMVP5YE DI DMVP5YE DMVP5YE DN Doxorubicin DMVP5YE MI TTQY2EJ DMVP5YE MN TERT messenger RNA (TERT mRNA) DMVP5YE MT DTT DMVP5YE RN Design and development of antisense drugs. Expert Opin. Drug Discov. 2008 3(10):1189-1207. DMVP5YE RU http://www.informahealthcare.com/doi/abs/10.1517/17460441.3.10.1177 DMVP5YE DI DMVP5YE DMVP5YE DN Doxorubicin DMVP5YE MI DECG04O DMVP5YE MN Xanthine dehydrogenase/oxidase (XDH) DMVP5YE MT DME DMVP5YE MA Metabolism DMVP5YE RN Xanthine oxidoreductase in drug metabolism: beyond a role as a detoxifying enzyme. Curr Med Chem. 2016;23(35):4027-4036. DMVP5YE RU https://www.ncbi.nlm.nih.gov/pubmed/?term=27458036 DM7ICNU DI DM7ICNU DM7ICNU DN Doxycycline DM7ICNU MI TTOVFH2 DM7ICNU MN Bacterial 30S ribosomal RNA (Bact 30S rRNA) DM7ICNU MT DTT DM7ICNU MA Modulator DM7ICNU RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. DM7ICNU RU https://www.fda.gov/ DM7ICNU DI DM7ICNU DM7ICNU DN Doxycycline DM7ICNU MI DE4LYSA DM7ICNU MN Cytochrome P450 3A4 (CYP3A4) DM7ICNU MT DME DM7ICNU MA Metabolism DM7ICNU RN A further interaction study of quinine with clinically important drugs by human liver microsomes: determinations of inhibition constant (Ki) and type of inhibition. Eur J Drug Metab Pharmacokinet. 1999 Jul-Sep;24(3):272-8. DM7ICNU RU https://www.ncbi.nlm.nih.gov/pubmed/?term=10716067 DM7ICNU DI DM7ICNU DM7ICNU DN Doxycycline DM7ICNU MI DTUGYRD DM7ICNU MN P-glycoprotein 1 (ABCB1) DM7ICNU MT DTP DM7ICNU MA Substrate DM7ICNU RN Mammalian drug efflux transporters of the ATP binding cassette (ABC) family in multidrug resistance: A review of the past decade. Cancer Lett. 2016 Jan 1;370(1):153-64. DM7ICNU RU http://www.ncbi.nlm.nih.gov/pubmed/26499806 DMKOXFE DI DMKOXFE DMKOXFE DN Doxylamine DMKOXFE MI TTTIBOJ DMKOXFE MN Histamine H1 receptor (H1R) DMKOXFE MT DTT DMKOXFE MA Antagonist DMKOXFE RN First-generation H1 antihistamines found in pilot fatalities of civil aviation accidents, 1990-2005. Aviat Space Environ Med. 2007 May;78(5):514-22. DMKOXFE RU https://pubmed.ncbi.nlm.nih.gov/17539447 DMGOXPQ DI DMGOXPQ DMGOXPQ DN DP-VPA DMGOXPQ MI TTNJYV2 DMGOXPQ MN Gamma-aminobutyric acid receptor (GAR) DMGOXPQ MT DTT DMGOXPQ MA Modulator DMGOXPQ RN DP-VPA D-Pharm. Curr Opin Investig Drugs. 2002 Jun;3(6):921-3. DMGOXPQ RU https://pubmed.ncbi.nlm.nih.gov/12137414 DMF2JDG DI DMF2JDG DMF2JDG DN Dromostanolone DMF2JDG MI TTS64P2 DMF2JDG MN Androgen receptor (AR) DMF2JDG MT DTT DMF2JDG MA Binder DMF2JDG RN Endocrinological and pathological effects of anabolic-androgenic steroid in male rats. Endocr J. 2004 Aug;51(4):425-34. DMF2JDG RU https://pubmed.ncbi.nlm.nih.gov/15351799 DMA8FS5 DI DMA8FS5 DMA8FS5 DN Dronedarone DMA8FS5 MI DECB0K3 DMA8FS5 MN Cytochrome P450 2D6 (CYP2D6) DMA8FS5 MT DME DMA8FS5 MA Metabolism DMA8FS5 RN Effect of dronedarone on the pharmacokinetics of carvedilol following oral administration to rats. Eur J Pharm Sci. 2018 Jan 1;111:13-19. DMA8FS5 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=28942006 DMA8FS5 DI DMA8FS5 DMA8FS5 DN Dronedarone DMA8FS5 MI DE4LYSA DMA8FS5 MN Cytochrome P450 3A4 (CYP3A4) DMA8FS5 MT DME DMA8FS5 MA Metabolism DMA8FS5 RN Drug safety evaluation of dronedarone in atrial fibrillation. Expert Opin Drug Saf. 2012 Nov;11(6):1023-45. DMA8FS5 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=22971242 DMA8FS5 DI DMA8FS5 DMA8FS5 DN Dronedarone DMA8FS5 MI DEIBDNY DMA8FS5 MN Cytochrome P450 3A5 (CYP3A5) DMA8FS5 MT DME DMA8FS5 MA Metabolism DMA8FS5 RN Inactivation of human cytochrome P450 3A4 and 3A5 by dronedarone and N-desbutyl dronedarone. Mol Pharmacol. 2016 Jan;89(1):1-13. DMA8FS5 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=26490246 DMA8FS5 DI DMA8FS5 DMA8FS5 DN Dronedarone DMA8FS5 MI TT1VOHK DMA8FS5 MN Potassium channel unspecific (KC) DMA8FS5 MT DTT DMA8FS5 MA Inhibitor DMA8FS5 RN Antibodies and venom peptides: new modalities for ion channels. Nat Rev Drug Discov. 2019 May;18(5):339-357. DMA8FS5 RU https://pubmed.ncbi.nlm.nih.gov/30728472 DMA8FS5 DI DMA8FS5 DMA8FS5 DN Dronedarone DMA8FS5 MI TTW0CMT DMA8FS5 MN Voltage-gated potassium channel Kv1.5 (KCNA5) DMA8FS5 MT DTT DMA8FS5 MA Blocker DMA8FS5 RN New antiarrhythmic agents for atrial fibrillation and atrial flutter. Expert Opin Emerg Drugs. 2005 May;10(2):311-22. DMA8FS5 RU https://pubmed.ncbi.nlm.nih.gov/15934869 DM0DXA8 DI DM0DXA8 DM0DXA8 DN Droperidol DM0DXA8 MI TTEX248 DM0DXA8 MN Dopamine D2 receptor (D2R) DM0DXA8 MT DTT DM0DXA8 MA Binder DM0DXA8 RN Alpha-adrenergic blockade: a possible mechanism of tocolytic action of certain benzodiazepines in a postpartum rat model in vivo. Life Sci. 2003 Jan 24;72(10):1093-102. DM0DXA8 RU https://pubmed.ncbi.nlm.nih.gov/12505540 DM1A9W3 DI DM1A9W3 DM1A9W3 DN Drospirenone DM1A9W3 MI DE4LYSA DM1A9W3 MN Cytochrome P450 3A4 (CYP3A4) DM1A9W3 MT DME DM1A9W3 MA Metabolism DM1A9W3 RN Role of CYP3A in oral contraceptives clearance. Clin Transl Sci. 2018 May;11(3):251-260. DM1A9W3 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=28986954 DM1A9W3 DI DM1A9W3 DM1A9W3 DN Drospirenone DM1A9W3 MI TT26PHO DM1A9W3 MN Mineralocorticoid receptor (MR) DM1A9W3 MT DTT DM1A9W3 MA Binder DM1A9W3 RN Biochemical mechanisms of New Molecular Entities (NMEs) approved by United States FDA during 2001-2004: mechanisms leading to optimal efficacy and ... Curr Top Med Chem. 2006;6(5):461-78. DM1A9W3 RU https://pubmed.ncbi.nlm.nih.gov/16719803 DM59JCN DI DM59JCN DM59JCN DN Drotrecogin alfa DM59JCN MI TT1O264 DM59JCN MN Coagulation factor Va (F5) DM59JCN MT DTT DM59JCN MA Inhibitor DM59JCN RN Protein C in critical illness. Am J Health Syst Pharm. 2009 Jun 15;66(12):1089-96. DM59JCN RU https://pubmed.ncbi.nlm.nih.gov/19498123 DM59JCN DI DM59JCN DM59JCN DN Drotrecogin alfa DM59JCN MI TT1290U DM59JCN MN Coagulation factor VIII (F8) DM59JCN MT DTT DM59JCN MA Inhibitor DM59JCN RN Protein C in critical illness. Am J Health Syst Pharm. 2009 Jun 15;66(12):1089-96. DM59JCN RU https://pubmed.ncbi.nlm.nih.gov/19498123 DM5YF4M DI DM5YF4M DM5YF4M DN Droxidopa DM5YF4M MI DETK9CN DM5YF4M MN DOPA decarboxylase (DDC) DM5YF4M MT DME DM5YF4M MA Metabolism DM5YF4M RN L-Dihydroxyphenylserine (L-DOPS): a norepinephrine prodrug. Cardiovasc Drug Rev. 2006 Fall-Winter;24(3-4):189-203. DM5YF4M RU https://www.ncbi.nlm.nih.gov/pubmed/?term=17214596 DMXZRW0 DI DMXZRW0 DMXZRW0 DN DTI-015 DMXZRW0 MI DEJGDUW DMXZRW0 MN Cytochrome P450 1A2 (CYP1A2) DMXZRW0 MT DME DMXZRW0 MA Metabolism DMXZRW0 RN Principal drug-metabolizing enzyme systems in L1210 leukemia sensitive or resistant to BCNU in vivo. Leuk Res. 1994 Nov;18(11):829-35. DMXZRW0 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=7967709 DMXZRW0 DI DMXZRW0 DMXZRW0 DN DTI-015 DMXZRW0 MI DE4ZHS1 DMXZRW0 MN Glutathione S-transferase alpha-1 (GSTA1) DMXZRW0 MT DME DMXZRW0 MA Metabolism DMXZRW0 RN Expression of glutathione S-transferase T1 (GSTT1) in human brain tumours. Histol Histopathol. 2006 Nov;21(11):1199-207. DMXZRW0 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=16874663 DMXZRW0 DI DMXZRW0 DMXZRW0 DN DTI-015 DMXZRW0 MI TTUTN1I DMXZRW0 MN Human Deoxyribonucleic acid (hDNA) DMXZRW0 MT DTT DMXZRW0 MA Binder DMXZRW0 RN Carmustine-induced toxicity, DNA crosslinking and O6-methylguanine-DNA methyltransferase activity in two human lung cancer cell lines. Eur J Cancer. 1991;27(12):1658-62. DMXZRW0 RU https://pubmed.ncbi.nlm.nih.gov/1664221 DMCIJBH DI DMCIJBH DMCIJBH DN DU-176B DMCIJBH MI TTCIHJA DMCIJBH MN Coagulation factor Xa (F10) DMCIJBH MT DTT DMCIJBH MA Modulator DMCIJBH RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2359). DMCIJBH RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2359 DMCIJBH DI DMCIJBH DMCIJBH DN DU-176B DMCIJBH MI DE4LYSA DMCIJBH MN Cytochrome P450 3A4 (CYP3A4) DMCIJBH MT DME DMCIJBH MA Metabolism DMCIJBH RN Edoxaban drug-drug interactions with ketoconazole, erythromycin, and cyclosporine. Br J Clin Pharmacol. 2016 Dec;82(6):1591-1600. DMCIJBH RU https://www.ncbi.nlm.nih.gov/pubmed/?term=27530188 DMCIJBH DI DMCIJBH DMCIJBH DN DU-176B DMCIJBH MI DTUGYRD DMCIJBH MN P-glycoprotein 1 (ABCB1) DMCIJBH MT DTP DMCIJBH MA Substrate DMCIJBH RN Edoxaban drug-drug interactions with ketoconazole, erythromycin, and cyclosporine. Br J Clin Pharmacol. 2016 Dec;82(6):1591-1600. DMCIJBH RU http://www.ncbi.nlm.nih.gov/pubmed/27530188 DMYXBV3 DI DMYXBV3 DMYXBV3 DN Dulaglutide DMYXBV3 MI TTVIMDE DMYXBV3 MN Glucagon-like peptide 1 receptor (GLP1R) DMYXBV3 MT DTT DMYXBV3 MA Agonist DMYXBV3 RN 2014 FDA drug approvals. Nat Rev Drug Discov. 2015 Feb;14(2):77-81. DMYXBV3 RU https://pubmed.ncbi.nlm.nih.gov/25633781 DM9BI7M DI DM9BI7M DM9BI7M DN Duloxetine DM9BI7M MI DEJGDUW DM9BI7M MN Cytochrome P450 1A2 (CYP1A2) DM9BI7M MT DME DM9BI7M MA Metabolism DM9BI7M RN Duloxetine: clinical pharmacokinetics and drug interactions. Clin Pharmacokinet. 2011 May;50(5):281-94. DM9BI7M RU https://www.ncbi.nlm.nih.gov/pubmed/?term=21366359 DM9BI7M DI DM9BI7M DM9BI7M DN Duloxetine DM9BI7M MI DE5IED8 DM9BI7M MN Cytochrome P450 2C9 (CYP2C9) DM9BI7M MT DME DM9BI7M MA Metabolism DM9BI7M RN Duloxetine: clinical pharmacokinetics and drug interactions. Clin Pharmacokinet. 2011 May;50(5):281-94. DM9BI7M RU https://www.ncbi.nlm.nih.gov/pubmed/?term=21366359 DM9BI7M DI DM9BI7M DM9BI7M DN Duloxetine DM9BI7M MI DECB0K3 DM9BI7M MN Cytochrome P450 2D6 (CYP2D6) DM9BI7M MT DME DM9BI7M MA Metabolism DM9BI7M RN Duloxetine: clinical pharmacokinetics and drug interactions. Clin Pharmacokinet. 2011 May;50(5):281-94. DM9BI7M RU https://www.ncbi.nlm.nih.gov/pubmed/?term=21366359 DM9BI7M DI DM9BI7M DM9BI7M DN Duloxetine DM9BI7M MI TTAWNKZ DM9BI7M MN Norepinephrine transporter (NET) DM9BI7M MT DTT DM9BI7M MA Inhibitor DM9BI7M RN Multi-target therapeutics: when the whole is greater than the sum of the parts. Drug Discov Today. 2007 Jan;12(1-2):34-42. DM9BI7M RU https://pubmed.ncbi.nlm.nih.gov/17198971 DM9BI7M DI DM9BI7M DM9BI7M DN Duloxetine DM9BI7M MI TT3ROYC DM9BI7M MN Serotonin transporter (SERT) DM9BI7M MT DTT DM9BI7M MA Inhibitor DM9BI7M RN Multi-target therapeutics: when the whole is greater than the sum of the parts. Drug Discov Today. 2007 Jan;12(1-2):34-42. DM9BI7M RU https://pubmed.ncbi.nlm.nih.gov/17198971 DMOAD2Y DI DMOAD2Y DMOAD2Y DN Dupilumab DMOAD2Y MI TTDWHC3 DMOAD2Y MN Interleukin 4 receptor alpha (IL4R) DMOAD2Y MT DTT DMOAD2Y RN Dupilumab in persistent asthma with elevated eosinophil levels. N Engl J Med. 2013 Jun 27;368(26):2455-66. DMOAD2Y RU https://pubmed.ncbi.nlm.nih.gov/23688323 DM4PVDY DI DM4PVDY DM4PVDY DN Durvalumab DM4PVDY MI TT8ZLTI DM4PVDY MN Programmed cell death 1 ligand 1 (PD-L1) DM4PVDY MT DTT DM4PVDY MA Modulator DM4PVDY RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. DM4PVDY RU https://www.fda.gov/ DMQ4TJK DI DMQ4TJK DMQ4TJK DN Dutasteride DMQ4TJK MI DECB0K3 DMQ4TJK MN Cytochrome P450 2D6 (CYP2D6) DMQ4TJK MT DME DMQ4TJK MA Metabolism DMQ4TJK RN Duloxetine: clinical pharmacokinetics and drug interactions. Clin Pharmacokinet. 2011 May;50(5):281-94. DMQ4TJK RU https://www.ncbi.nlm.nih.gov/pubmed/?term=21366359 DMQ4TJK DI DMQ4TJK DMQ4TJK DN Dutasteride DMQ4TJK MI DEIBDNY DMQ4TJK MN Cytochrome P450 3A5 (CYP3A5) DMQ4TJK MT DME DMQ4TJK MA Metabolism DMQ4TJK RN Product monograph: Avodart (dutasteride capsules). DMQ4TJK RU https://ca.gsk.com/media/588688/avodart.pdf DMQ4TJK DI DMQ4TJK DMQ4TJK DN Dutasteride DMQ4TJK MI TT2A0DR DMQ4TJK MN Oxo-5-alpha-steroid 4-dehydrogenase (SRD5A) DMQ4TJK MT DTT DMQ4TJK MA Inhibitor DMQ4TJK RN The role of 5-alpha reductase inhibitors in prostate pathophysiology: Is there an additional advantage to inhibition of type 1 isoenzyme Can Urol Assoc J. 2009 Jun;3(3 Suppl 2):S109-14. DMQ4TJK RU https://pubmed.ncbi.nlm.nih.gov/19543428 DMU6OFP DI DMU6OFP DMU6OFP DN Dyclonine DMU6OFP MI TTZOVE0 DMU6OFP MN Voltage-gated sodium channel alpha Nav1.5 (SCN5A) DMU6OFP MT DTT DMU6OFP MA Blocker DMU6OFP RN Monoamine transporter and sodium channel mechanisms in the rapid pressor response to cocaine. Pharmacol Biochem Behav. 1998 Feb;59(2):305-12. DMU6OFP RU https://pubmed.ncbi.nlm.nih.gov/9476974 DMAKIDV DI DMAKIDV DMAKIDV DN Dydrogesterone DMAKIDV MI DE4LYSA DMAKIDV MN Cytochrome P450 3A4 (CYP3A4) DMAKIDV MT DME DMAKIDV MA Metabolism DMAKIDV RN Dydrogesterone metabolism in human liver by aldo-keto reductases and cytochrome P450 enzymes. Xenobiotica. 2016 Oct;46(10):868-74. DMAKIDV RU https://www.ncbi.nlm.nih.gov/pubmed/?term=26796435 DMAKIDV DI DMAKIDV DMAKIDV DN Dydrogesterone DMAKIDV MI TTUV8G9 DMAKIDV MN Progesterone receptor (PGR) DMAKIDV MT DTT DMAKIDV MA Agonist DMAKIDV RN Dienogest is a selective progesterone receptor agonist in transactivation analysis with potent oral endometrial activity due to its efficient pharm... Steroids. 2008 Feb;73(2):222-31. DMAKIDV RU https://pubmed.ncbi.nlm.nih.gov/18061638 DM8DZC1 DI DM8DZC1 DM8DZC1 DN Dyphylline DM8DZC1 MI TTZ97H5 DM8DZC1 MN Phosphodiesterase 4A (PDE4A) DM8DZC1 MT DTT DM8DZC1 MA Inhibitor DM8DZC1 RN Ocular hypotension induced by topical dopaminergic drugs and phosphodiesterase inhibitors. Eur J Pharmacol. 1994 Jun 2;258(1-2):85-94. DM8DZC1 RU https://pubmed.ncbi.nlm.nih.gov/7925603 DMJDYNQ DI DMJDYNQ DMJDYNQ DN E-2007 DMJDYNQ MI DEJGDUW DMJDYNQ MN Cytochrome P450 1A2 (CYP1A2) DMJDYNQ MT DME DMJDYNQ MA Metabolism DMJDYNQ RN Perampanel (Fycompa): a review of clinical efficacy and safety in epilepsy. P T. 2016 Nov;41(11):683-698. DMJDYNQ RU https://www.ncbi.nlm.nih.gov/pubmed/?term=27904300 DMJDYNQ DI DMJDYNQ DMJDYNQ DN E-2007 DMJDYNQ MI DE4LYSA DMJDYNQ MN Cytochrome P450 3A4 (CYP3A4) DMJDYNQ MT DME DMJDYNQ MA Metabolism DMJDYNQ RN The clinical pharmacology profile of the new antiepileptic drug perampanel: A novel noncompetitive AMPA receptor antagonist. Epilepsia. 2015 Jan;56(1):12-27. DMJDYNQ RU https://www.ncbi.nlm.nih.gov/pubmed/?term=25495693 DMJDYNQ DI DMJDYNQ DMJDYNQ DN E-2007 DMJDYNQ MI DEIBDNY DMJDYNQ MN Cytochrome P450 3A5 (CYP3A5) DMJDYNQ MT DME DMJDYNQ MA Metabolism DMJDYNQ RN FDA label of Perampanel. The 2020 official website of the U.S. Food and Drug Administration. DMJDYNQ RU https://www.accessdata.fda.gov/drugsatfda_docs/label/2016/202834s011lbl.pdf DMJDYNQ DI DMJDYNQ DMJDYNQ DN E-2007 DMJDYNQ MI TTAN6JD DMJDYNQ MN Glutamate receptor AMPA (GRIA) DMJDYNQ MT DTT DMJDYNQ MA Modulator DMJDYNQ RN Nat Rev Drug Discov. 2013 Feb;12(2):87-90. DMJDYNQ RU https://pubmed.ncbi.nlm.nih.gov/23370234 DMJDYNQ DI DMJDYNQ DMJDYNQ DN E-2007 DMJDYNQ MI TTVPQTF DMJDYNQ MN Glutamate receptor AMPA 1 (GRIA1) DMJDYNQ MT DTT DMJDYNQ MA Inhibitor DMJDYNQ RN Antibodies and venom peptides: new modalities for ion channels. Nat Rev Drug Discov. 2019 May;18(5):339-357. DMJDYNQ RU https://pubmed.ncbi.nlm.nih.gov/30728472 DMJDYNQ DI DMJDYNQ DMJDYNQ DN E-2007 DMJDYNQ MI TT9HLZ0 DMJDYNQ MN Glutamate receptor AMPA 2 (GRIA2) DMJDYNQ MT DTT DMJDYNQ MA Inhibitor DMJDYNQ RN Antibodies and venom peptides: new modalities for ion channels. Nat Rev Drug Discov. 2019 May;18(5):339-357. DMJDYNQ RU https://pubmed.ncbi.nlm.nih.gov/30728472 DMJDYNQ DI DMJDYNQ DMJDYNQ DN E-2007 DMJDYNQ MI TT82EZV DMJDYNQ MN Glutamate receptor AMPA 3 (GRIA3) DMJDYNQ MT DTT DMJDYNQ MA Inhibitor DMJDYNQ RN Antibodies and venom peptides: new modalities for ion channels. Nat Rev Drug Discov. 2019 May;18(5):339-357. DMJDYNQ RU https://pubmed.ncbi.nlm.nih.gov/30728472 DMJDYNQ DI DMJDYNQ DMJDYNQ DN E-2007 DMJDYNQ MI TTPJR0G DMJDYNQ MN Glutamate receptor AMPA 4 (GRIA4) DMJDYNQ MT DTT DMJDYNQ MA Inhibitor DMJDYNQ RN Antibodies and venom peptides: new modalities for ion channels. Nat Rev Drug Discov. 2019 May;18(5):339-357. DMJDYNQ RU https://pubmed.ncbi.nlm.nih.gov/30728472 DMOF2C6 DI DMOF2C6 DMOF2C6 DN Ecallantide DMOF2C6 MI TT5L2VC DMOF2C6 MN Kallikrein-related peptidase (KLK) DMOF2C6 MT DTT DMOF2C6 MA Inhibitor DMOF2C6 RN Ecallantide (DX-88), a plasma kallikrein inhibitor for the treatment of hereditary angioedema and the prevention of blood loss in on-pump cardiothoracic surgery. Expert Opin Biol Ther. 2008 Aug;8(8):1187-99. DMOF2C6 RU https://pubmed.ncbi.nlm.nih.gov/18613770 DMOF2C6 DI DMOF2C6 DMOF2C6 DN Ecallantide DMOF2C6 MI TTMF8H9 DMOF2C6 MN Plasma kallikrein (KLKB1) DMOF2C6 MT DTT DMOF2C6 MA Inhibitor DMOF2C6 RN Ecallantide (DX-88), a plasma kallikrein inhibitor for the treatment of hereditary angioedema and the prevention of blood loss in on-pump cardiothoracic surgery. Expert Opin Biol Ther. 2008 Aug;8(8):1187-99. DMOF2C6 RU https://pubmed.ncbi.nlm.nih.gov/18613770 DMSNVGB DI DMSNVGB DMSNVGB DN Echothiophate Iodide DMSNVGB MI TT1RS9F DMSNVGB MN Acetylcholinesterase (AChE) DMSNVGB MT DTT DMSNVGB MA Modulator DMSNVGB RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. DMSNVGB RU https://www.fda.gov/ DMFSWGH DI DMFSWGH DMFSWGH DN Econazole DMFSWGH MI TTTSOUD DMFSWGH MN Candida Cytochrome P450 51 (Candi ERG11) DMFSWGH MT DTT DMFSWGH MA Inhibitor DMFSWGH RN Differential azole antifungal efficacies contrasted using a Saccharomyces cerevisiae strain humanized for sterol 14 alpha-demethylase at the homolo... Antimicrob Agents Chemother. 2008 Oct;52(10):3597-603. DMFSWGH RU https://pubmed.ncbi.nlm.nih.gov/18694951 DMCRQHB DI DMCRQHB DMCRQHB DN Edrophonium DMCRQHB MI TT1RS9F DMCRQHB MN Acetylcholinesterase (AChE) DMCRQHB MT DTT DMCRQHB MA Inhibitor DMCRQHB RN Screening of acetylcholinesterase inhibitors by CE after enzymatic reaction at capillary inlet. J Sep Sci. 2009 May;32(10):1748-56. DMCRQHB RU https://pubmed.ncbi.nlm.nih.gov/19472276 DMCKL5V DI DMCKL5V DMCKL5V DN Efalizumab DMCKL5V MI TT48WR6 DMCKL5V MN Integrin alpha-L (ITGAL) DMCKL5V MT DTT DMCKL5V RN [Successful therapy of discoid lupus erythematosus with efalizumab]. Hautarzt. 2010 Mar;61(3):246-9. DMCKL5V RU https://pubmed.ncbi.nlm.nih.gov/19436973 DMC0GSJ DI DMC0GSJ DMC0GSJ DN Efavirenz DMC0GSJ MI DEJGDUW DMC0GSJ MN Cytochrome P450 1A2 (CYP1A2) DMC0GSJ MT DME DMC0GSJ MA Metabolism DMC0GSJ RN CYP2B6 genotype-dependent inhibition of CYP1A2 and induction of CYP2A6 by the antiretroviral drug efavirenz in healthy volunteers. Clin Transl Sci. 2019 Nov;12(6):657-666. DMC0GSJ RU https://www.ncbi.nlm.nih.gov/pubmed/?term=31339646 DMC0GSJ DI DMC0GSJ DMC0GSJ DN Efavirenz DMC0GSJ MI DEPKLMQ DMC0GSJ MN Cytochrome P450 2B6 (CYP2B6) DMC0GSJ MT DME DMC0GSJ MA Metabolism DMC0GSJ RN Evaluation of CYP2B6 induction and prediction of clinical drug-drug interactions: considerations from the IQ consortium induction working group-an industry perspective. Drug Metab Dispos. 2016 Oct;44(10):1720-30. DMC0GSJ RU https://www.ncbi.nlm.nih.gov/pubmed/?term=27422672 DMC0GSJ DI DMC0GSJ DMC0GSJ DN Efavirenz DMC0GSJ MI DE4LYSA DMC0GSJ MN Cytochrome P450 3A4 (CYP3A4) DMC0GSJ MT DME DMC0GSJ MA Metabolism DMC0GSJ RN Induction of CYP3A4 by efavirenz in primary human hepatocytes: comparison with rifampin and phenobarbital. J Clin Pharmacol. 2004 Nov;44(11):1273-81. DMC0GSJ RU https://www.ncbi.nlm.nih.gov/pubmed/?term=15496645 DMC0GSJ DI DMC0GSJ DMC0GSJ DN Efavirenz DMC0GSJ MI TT84ETX DMC0GSJ MN Human immunodeficiency virus Reverse transcriptase (HIV RT) DMC0GSJ MT DTT DMC0GSJ MA Modulator DMC0GSJ RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. DMC0GSJ RU https://www.fda.gov/ DMC0GSJ DI DMC0GSJ DMC0GSJ DN Efavirenz DMC0GSJ MI DTQ3ZHF DMC0GSJ MN Multidrug resistance-associated protein 3 (ABCC3) DMC0GSJ MT DTP DMC0GSJ MA Substrate DMC0GSJ RN Induction of multiple drug transporters by efavirenz. J Pharmacol Sci. 2009 Feb;109(2):242-50. DMC0GSJ RU https://doi.org/10.1254/jphs.08209FP DMC0GSJ DI DMC0GSJ DMC0GSJ DN Efavirenz DMC0GSJ MI DTUGYRD DMC0GSJ MN P-glycoprotein 1 (ABCB1) DMC0GSJ MT DTP DMC0GSJ MA Substrate DMC0GSJ RN Human intestinal transporter database: QSAR modeling and virtual profiling of drug uptake, efflux and interactions. Pharm Res. 2013 Apr;30(4):996-1007. DMC0GSJ RU https://doi.org/10.1007/s11095-012-0935-x DMFA9MV DI DMFA9MV DMFA9MV DN Efinaconazole DMFA9MV MI TTTSOUD DMFA9MV MN Candida Cytochrome P450 51 (Candi ERG11) DMFA9MV MT DTT DMFA9MV MA Inhibitor DMFA9MV RN Efinaconazole: Developmental and reproductive toxicity potential of a novel antifungal azole. Reprod Toxicol. 2015 Apr;52:18-25. DMFA9MV RU https://pubmed.ncbi.nlm.nih.gov/25527861 DMJOQM3 DI DMJOQM3 DMJOQM3 DN Eflornithine DMJOQM3 MI TTUMGNO DMJOQM3 MN Ornithine decarboxylase (ODC1) DMJOQM3 MT DTT DMJOQM3 MA Inhibitor DMJOQM3 RN Plasmodium falciparum and Plasmodium berghei: effects of ornithine decarboxylase inhibitors on erythrocytic schizogony. Exp Parasitol. 1987 Oct;64(2):237-43. DMJOQM3 RU https://pubmed.ncbi.nlm.nih.gov/3115816 DMMUCG4 DI DMMUCG4 DMMUCG4 DN Eicosapentaenoic acid/docosa-hexaenoic acid DMMUCG4 MI DE5IED8 DMMUCG4 MN Cytochrome P450 2C9 (CYP2C9) DMMUCG4 MT DME DMMUCG4 MA Metabolism DMMUCG4 RN CYP-eicosanoids--a new link between omega-3 fatty acids and cardiac disease? Prostaglandins Other Lipid Mediat. 2011 Nov;96(1-4):99-108. DMMUCG4 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=21945326 DMMUCG4 DI DMMUCG4 DMMUCG4 DN Eicosapentaenoic acid/docosa-hexaenoic acid DMMUCG4 MI DT5G94L DMMUCG4 MN Major facilitator superfamily domain-containing protein 2A (SLC59A1) DMMUCG4 MT DTP DMMUCG4 MA Substrate DMMUCG4 RN Mfsd2a Is a Transporter for the Essential -3 Fatty Acid Docosahexaenoic Acid (DHA) in Eye and Is Important for Photoreceptor Cell Development. J Biol Chem. 2016 May 13;291(20):10501-14. DMMUCG4 RU http://www.ncbi.nlm.nih.gov/pubmed/27008858 DMMUCG4 DI DMMUCG4 DMMUCG4 DN Eicosapentaenoic acid/docosa-hexaenoic acid DMMUCG4 MI TT8NGED DMMUCG4 MN Prostaglandin G/H synthase 1 (COX-1) DMMUCG4 MT DTT DMMUCG4 MA Inhibitor DMMUCG4 RN Cox-2 inhibitory effects of naturally occurring and modified fatty acids. J Nat Prod. 2001 Jun;64(6):745-9. DMMUCG4 RU https://pubmed.ncbi.nlm.nih.gov/11421736 DMMUCG4 DI DMMUCG4 DMMUCG4 DN Eicosapentaenoic acid/docosa-hexaenoic acid DMMUCG4 MI DE073H6 DMMUCG4 MN Prostaglandin G/H synthase 1 (COX-1) DMMUCG4 MT DME DMMUCG4 MA Metabolism DMMUCG4 RN Divergent cyclooxygenase responses to fatty acid structure and peroxide level in fish and mammalian prostaglandin H synthases. FASEB J. 2006 Jun;20(8):1097-108. DMMUCG4 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=16770009 DMMUCG4 DI DMMUCG4 DMMUCG4 DN Eicosapentaenoic acid/docosa-hexaenoic acid DMMUCG4 MI TTVKILB DMMUCG4 MN Prostaglandin G/H synthase 2 (COX-2) DMMUCG4 MT DTT DMMUCG4 MA Inhibitor DMMUCG4 RN Cox-2 inhibitory effects of naturally occurring and modified fatty acids. J Nat Prod. 2001 Jun;64(6):745-9. DMMUCG4 RU https://pubmed.ncbi.nlm.nih.gov/11421736 DMMUCG4 DI DMMUCG4 DMMUCG4 DN Eicosapentaenoic acid/docosa-hexaenoic acid DMMUCG4 MI DE492CE DMMUCG4 MN Prostaglandin G/H synthase 2 (COX-2) DMMUCG4 MT DME DMMUCG4 MA Metabolism DMMUCG4 RN Divergent cyclooxygenase responses to fatty acid structure and peroxide level in fish and mammalian prostaglandin H synthases. FASEB J. 2006 Jun;20(8):1097-108. DMMUCG4 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=16770009 DMRDUC0 DI DMRDUC0 DMRDUC0 DN Elagolix sodium DMRDUC0 MI TT8R70G DMRDUC0 MN Gonadotropin-releasing hormone receptor (GNRHR) DMRDUC0 MT DTT DMRDUC0 MA Antagonist DMRDUC0 RN 2018 FDA drug approvals.Nat Rev Drug Discov. 2019 Feb;18(2):85-89. DMRDUC0 RU https://pubmed.ncbi.nlm.nih.gov/30710142 DMS7OU8 DI DMS7OU8 DMS7OU8 DN Elapegademase DMS7OU8 MI TTLP57V DMS7OU8 MN Adenosine deaminase (ADA) DMS7OU8 MT DTT DMS7OU8 MA Modulator DMS7OU8 RN 2018 FDA drug approvals.Nat Rev Drug Discov. 2019 Feb;18(2):85-89. DMS7OU8 RU https://pubmed.ncbi.nlm.nih.gov/30710142 DMJLE18 DI DMJLE18 DMJLE18 DN Elbasvir DMJLE18 MI DE4LYSA DMJLE18 MN Cytochrome P450 3A4 (CYP3A4) DMJLE18 MT DME DMJLE18 MA Metabolism DMJLE18 RN Clinical pharmacokinetics and drug-drug interactions of Elbasvir/Grazoprevir. Eur J Drug Metab Pharmacokinet. 2018 Oct;43(5):509-531. DMJLE18 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=29557529 DMW649X DI DMW649X DMW649X DN Eletriptan DMW649X MI TTK8CXU DMW649X MN 5-HT 1B receptor (HTR1B) DMW649X MT DTT DMW649X MA Modulator DMW649X RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. DMW649X RU https://www.fda.gov/ DMW649X DI DMW649X DMW649X DN Eletriptan DMW649X MI TT6MSOK DMW649X MN 5-HT 1D receptor (HTR1D) DMW649X MT DTT DMW649X MA Modulator DMW649X RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. DMW649X RU https://www.fda.gov/ DMW649X DI DMW649X DMW649X DN Eletriptan DMW649X MI DE5IED8 DMW649X MN Cytochrome P450 2C9 (CYP2C9) DMW649X MT DME DMW649X MA Metabolism DMW649X RN Eletriptan in the management of acute migraine: an update on the evidence for efficacy, safety, and consistent response. Ther Adv Neurol Disord. 2016 Sep;9(5):414-23. DMW649X RU https://www.ncbi.nlm.nih.gov/pubmed/?term=27582896 DMW649X DI DMW649X DMW649X DN Eletriptan DMW649X MI DECB0K3 DMW649X MN Cytochrome P450 2D6 (CYP2D6) DMW649X MT DME DMW649X MA Metabolism DMW649X RN Eletriptan metabolism by human hepatic CYP450 enzymes and transport by human P-glycoprotein. Drug Metab Dispos. 2003 Jul;31(7):861-9. DMW649X RU https://www.ncbi.nlm.nih.gov/pubmed/?term=12814962 DMW649X DI DMW649X DMW649X DN Eletriptan DMW649X MI DE4LYSA DMW649X MN Cytochrome P450 3A4 (CYP3A4) DMW649X MT DME DMW649X MA Metabolism DMW649X RN Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. 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DMA9REV RU https://pubmed.ncbi.nlm.nih.gov/25633781 DMEYHG9 DI DMEYHG9 DMEYHG9 DN Elotuzumab DMEYHG9 MI TT7ILZ1 DMEYHG9 MN SLAM family member 7 SLAMF7 (CS1) DMEYHG9 MT DTT DMEYHG9 RN Market watch: Upcoming catalysts in Q2 2015. Nat Rev Drug Discov. 2015 Apr;14(4):228. DMEYHG9 RU https://pubmed.ncbi.nlm.nih.gov/25764988 DMOGFIX DI DMOGFIX DMOGFIX DN Eltrombopag DMOGFIX MI DTI7UX6 DMOGFIX MN Breast cancer resistance protein (ABCG2) DMOGFIX MT DTP DMOGFIX MA Substrate DMOGFIX RN Assessment of the pharmacokinetic interaction between eltrombopag and lopinavir-ritonavir in healthy adult subjects. Antimicrob Agents Chemother. 2012 Jun;56(6):2846-51. DMOGFIX RU https://doi.org/10.1128/AAC.05214-11 DMOGFIX DI DMOGFIX DMOGFIX DN Eltrombopag DMOGFIX MI DEJGDUW DMOGFIX MN Cytochrome P450 1A2 (CYP1A2) DMOGFIX MT DME DMOGFIX MA Metabolism DMOGFIX RN Eltrombopag for use in children with immune thrombocytopenia. Blood Adv. 2018 Feb 27;2(4):454-461. DMOGFIX RU https://www.ncbi.nlm.nih.gov/pubmed/?term=29487060 DMOGFIX DI DMOGFIX DMOGFIX DN Eltrombopag DMOGFIX MI DES5XRU DMOGFIX MN Cytochrome P450 2C8 (CYP2C8) DMOGFIX MT DME DMOGFIX MA Metabolism DMOGFIX RN Eltrombopag-induced acute liver failure in a pediatric patient: a pharmacokinetic and pharmacogenetic analysis. Ther Drug Monit. 2018 Aug;40(4):386-388. DMOGFIX RU https://www.ncbi.nlm.nih.gov/pubmed/?term=29683873 DMOGFIX DI DMOGFIX DMOGFIX DN Eltrombopag DMOGFIX MI DTPFTEQ DMOGFIX MN Organic anion transporting polypeptide 2B1 (SLCO2B1) DMOGFIX MT DTP DMOGFIX MA Substrate DMOGFIX RN Pharmacokinetics and hepatic uptake of eltrombopag, a novel platelet-increasing agent. Drug Metab Dispos. 2011 Jun;39(6):1088-96. DMOGFIX RU http://www.ncbi.nlm.nih.gov/pubmed/21422191 DMOGFIX DI DMOGFIX DMOGFIX DN Eltrombopag DMOGFIX MI TTIHYA4 DMOGFIX MN Thrombopoietin receptor (MPL) DMOGFIX MT DTT DMOGFIX MA Agonist DMOGFIX RN Emerging drugs for idiopathic thrombocytopenic purpura in adults. Expert Opin Emerg Drugs. 2008 Jun;13(2):237-54. DMOGFIX RU https://pubmed.ncbi.nlm.nih.gov/18537519 DMOGFIX DI DMOGFIX DMOGFIX DN Eltrombopag DMOGFIX MI DEYGVN4 DMOGFIX MN UDP-glucuronosyltransferase 1A1 (UGT1A1) DMOGFIX MT DME DMOGFIX MA Metabolism DMOGFIX RN Eltrombopag-induced acute liver failure in a pediatric patient: a pharmacokinetic and pharmacogenetic analysis. Ther Drug Monit. 2018 Aug;40(4):386-388. DMOGFIX RU https://www.ncbi.nlm.nih.gov/pubmed/?term=29683873 DMYZ0P1 DI DMYZ0P1 DMYZ0P1 DN Eluxadoline DMYZ0P1 MI TT27RFC DMYZ0P1 MN Opioid receptor delta (OPRD1) DMYZ0P1 MT DTT DMYZ0P1 MA Modulator DMYZ0P1 RN Molecular characterization of eluxadoline as a potential ligand targeting mu-delta opioid receptor heteromers.Biochem Pharmacol.2014 Dec 1;92(3):448-56. DMYZ0P1 RU https://www.ncbi.nlm.nih.gov/pubmed/25261794 DMYZ0P1 DI DMYZ0P1 DMYZ0P1 DN Eluxadoline DMYZ0P1 MI TTKWM86 DMYZ0P1 MN Opioid receptor mu (MOP) DMYZ0P1 MT DTT DMYZ0P1 MA Modulator DMYZ0P1 RN Molecular characterization of eluxadoline as a potential ligand targeting mu-delta opioid receptor heteromers.Biochem Pharmacol.2014 Dec 1;92(3):448-56. DMYZ0P1 RU https://www.ncbi.nlm.nih.gov/pubmed/25261794 DMYZ0P1 DI DMYZ0P1 DMYZ0P1 DN Eluxadoline DMYZ0P1 MI DT3D8F0 DMYZ0P1 MN Organic anion transporting polypeptide 1B1 (SLCO1B1) DMYZ0P1 MT DTP DMYZ0P1 MA Substrate DMYZ0P1 RN Effect of uptake transporters OAT3 and OATP1B1 and efflux transporter MRP2 on the pharmacokinetics of eluxadoline. J Clin Pharmacol. 2015 May;55(5):534-42. DMYZ0P1 RU http://www.ncbi.nlm.nih.gov/pubmed/25491493 DMG9B1U DI DMG9B1U DMG9B1U DN Elvitegravir DMG9B1U MI DE4LYSA DMG9B1U MN Cytochrome P450 3A4 (CYP3A4) DMG9B1U MT DME DMG9B1U MA Metabolism DMG9B1U RN FDA Label of Elvitegravir. The 2020 official website of the U.S. Food and Drug Administration. DMG9B1U RU https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/203100s030lbl.pdf DMG9B1U DI DMG9B1U DMG9B1U DN Elvitegravir DMG9B1U MI TT5FH9Y DMG9B1U MN Human immunodeficiency virus Integrase (HIV IN) DMG9B1U MT DTT DMG9B1U MA Modulator DMG9B1U RN Radium 223 dichloride for prostate cancer treatment. Drug Des Devel Ther. 2017 Sep 6;11:2643-2651. DMG9B1U RU https://pubmed.ncbi.nlm.nih.gov/28919714 DMG9B1U DI DMG9B1U DMG9B1U DN Elvitegravir DMG9B1U MI DEYGVN4 DMG9B1U MN UDP-glucuronosyltransferase 1A1 (UGT1A1) DMG9B1U MT DME DMG9B1U MA Metabolism DMG9B1U RN Elvitegravir for the treatment of HIV infection. Drugs Today (Barc). 2014 Mar;50(3):209-17. DMG9B1U RU https://www.ncbi.nlm.nih.gov/pubmed/?term=24696866 DMZG5WL DI DMZG5WL DMZG5WL DN Emapalumab DMZG5WL MI TT93WF5 DMZG5WL MN Interferon-gamma (IFNG) DMZG5WL MT DTT DMZG5WL MA Modulator DMZG5WL RN 2018 FDA drug approvals.Nat Rev Drug Discov. 2019 Feb;18(2):85-89. DMZG5WL RU https://pubmed.ncbi.nlm.nih.gov/30710142 DM36LAJ DI DM36LAJ DM36LAJ DN Emedastine DM36LAJ MI TTTIBOJ DM36LAJ MN Histamine H1 receptor (H1R) DM36LAJ MT DTT DM36LAJ MA Antagonist DM36LAJ RN Emedastine difumarate: a review of its potential ameliorating effect for tissue remodeling in allergic diseases. Expert Opin Pharmacother. 2009 Aug;10(11):1859-67. DM36LAJ RU https://pubmed.ncbi.nlm.nih.gov/19558341 DMCOAVT DI DMCOAVT DMCOAVT DN Emepronium DMCOAVT MI TTH18TF DMCOAVT MN Muscarinic acetylcholine receptor M5 (CHRM5) DMCOAVT MT DTT DMCOAVT MA Modulator DMCOAVT RN Classification of the presynaptic muscarinic receptor subtype that regulates 3H-acetylcholine secretion in the guinea pig urinary bladder in vitro. J Pharmacol Exp Ther. 1995 Jul;274(1):458-68. DMCOAVT RU https://pubmed.ncbi.nlm.nih.gov/7616431 DMCT2YF DI DMCT2YF DMCT2YF DN Emetine DMCT2YF MI DECB0K3 DMCT2YF MN Cytochrome P450 2D6 (CYP2D6) DMCT2YF MT DME DMCT2YF MA Metabolism DMCT2YF RN Metabolism of ipecac alkaloids cephaeline and emetine by human hepatic microsomal cytochrome P450s, and their inhibitory effects on P450 enzyme activities. Biol Pharm Bull. 2001 Jun;24(6):678-82. DMCT2YF RU https://www.ncbi.nlm.nih.gov/pubmed/?term=11411558 DMCT2YF DI DMCT2YF DMCT2YF DN Emetine DMCT2YF MI DE4LYSA DMCT2YF MN Cytochrome P450 3A4 (CYP3A4) DMCT2YF MT DME DMCT2YF MA Metabolism DMCT2YF RN Metabolism of ipecac alkaloids cephaeline and emetine by human hepatic microsomal cytochrome P450s, and their inhibitory effects on P450 enzyme activities. Biol Pharm Bull. 2001 Jun;24(6):678-82. DMCT2YF RU https://www.ncbi.nlm.nih.gov/pubmed/?term=11411558 DMCT2YF DI DMCT2YF DMCT2YF DN Emetine DMCT2YF MI DTUGYRD DMCT2YF MN P-glycoprotein 1 (ABCB1) DMCT2YF MT DTP DMCT2YF MA Substrate DMCT2YF RN Potential role of drug transporters in the pathogenesis of medically intractable epilepsy. Epilepsia. 2005 Feb;46(2):224-35. DMCT2YF RU https://doi.org/10.1111/j.0013-9580.2005.31904.x DM0AQ83 DI DM0AQ83 DM0AQ83 DN Emicizumab DM0AQ83 MI TTFEZ5Q DM0AQ83 MN Coagulation factor IX (F9) DM0AQ83 MT DTT DM0AQ83 MA Modulator DM0AQ83 RN 2017 FDA drug approvals.Nat Rev Drug Discov. 2018 Feb;17(2):81-85. DM0AQ83 RU https://pubmed.ncbi.nlm.nih.gov/29348678 DM0AQ83 DI DM0AQ83 DM0AQ83 DN Emicizumab DM0AQ83 MI TTCIHJA DM0AQ83 MN Coagulation factor Xa (F10) DM0AQ83 MT DTT DM0AQ83 MA Modulator DM0AQ83 RN 2017 FDA drug approvals.Nat Rev Drug Discov. 2018 Feb;17(2):81-85. DM0AQ83 RU https://pubmed.ncbi.nlm.nih.gov/29348678 DMRF9YK DI DMRF9YK DMRF9YK DN Empagliflozin DMRF9YK MI DTI7UX6 DMRF9YK MN Breast cancer resistance protein (ABCG2) DMRF9YK MT DTP DMRF9YK MA Substrate DMRF9YK RN KEGG: new perspectives on genomes, pathways, diseases and drugs. Nucleic Acids Res. 2017 Jan 4;45(D1):D353-D361. (dg:DG01913) DMRF9YK RU https://www.kegg.jp/dbget-bin/www_bget?dg:DG01913 DMRF9YK DI DMRF9YK DMRF9YK DN Empagliflozin DMRF9YK MI DTUGYRD DMRF9YK MN P-glycoprotein 1 (ABCB1) DMRF9YK MT DTP DMRF9YK MA Substrate DMRF9YK RN KEGG: new perspectives on genomes, pathways, diseases and drugs. Nucleic Acids Res. 2017 Jan 4;45(D1):D353-D361. (dg:DG01665) DMRF9YK RU https://www.kegg.jp/dbget-bin/www_bget?dg:DG01665 DMRF9YK DI DMRF9YK DMRF9YK DN Empagliflozin DMRF9YK MI TTLWPVF DMRF9YK MN Sodium/glucose cotransporter 2 (SGLT2) DMRF9YK MT DTT DMRF9YK MA Modulator DMRF9YK RN 2014 FDA drug approvals. Nat Rev Drug Discov. 2015 Feb;14(2):77-81. DMRF9YK RU https://pubmed.ncbi.nlm.nih.gov/25633781 DMRF9YK DI DMRF9YK DMRF9YK DN Empagliflozin DMRF9YK MI DEF2WXN DMRF9YK MN UDP-glucuronosyltransferase 1A3 (UGT1A3) DMRF9YK MT DME DMRF9YK MA Metabolism DMRF9YK RN Empagliflozin (Jardiance): a novel SGLT2 inhibitor for the treatment of type-2 diabetes. P T. 2015 Jun;40(6):364-8. DMRF9YK RU https://www.ncbi.nlm.nih.gov/pubmed/?term=26045645 DMRF9YK DI DMRF9YK DMRF9YK DN Empagliflozin DMRF9YK MI DE2GB8N DMRF9YK MN UDP-glucuronosyltransferase 1A8 (UGT1A8) DMRF9YK MT DME DMRF9YK MA Metabolism DMRF9YK RN Empagliflozin (Jardiance): a novel SGLT2 inhibitor for the treatment of type-2 diabetes. P T. 2015 Jun;40(6):364-8. DMRF9YK RU https://www.ncbi.nlm.nih.gov/pubmed/?term=26045645 DMRF9YK DI DMRF9YK DMRF9YK DN Empagliflozin DMRF9YK MI DE85D2P DMRF9YK MN UDP-glucuronosyltransferase 1A9 (UGT1A9) DMRF9YK MT DME DMRF9YK MA Metabolism DMRF9YK RN Empagliflozin (Jardiance): a novel SGLT2 inhibitor for the treatment of type-2 diabetes. P T. 2015 Jun;40(6):364-8. DMRF9YK RU https://www.ncbi.nlm.nih.gov/pubmed/?term=26045645 DMRF9YK DI DMRF9YK DMRF9YK DN Empagliflozin DMRF9YK MI DEB3CV1 DMRF9YK MN UDP-glucuronosyltransferase 2B7 (UGT2B7) DMRF9YK MT DME DMRF9YK MA Metabolism DMRF9YK RN Empagliflozin (Jardiance): a novel SGLT2 inhibitor for the treatment of type-2 diabetes. P T. 2015 Jun;40(6):364-8. DMRF9YK RU https://www.ncbi.nlm.nih.gov/pubmed/?term=26045645 DMBMUWZ DI DMBMUWZ DMBMUWZ DN Emtricitabine DMBMUWZ MI TT84ETX DMBMUWZ MN Human immunodeficiency virus Reverse transcriptase (HIV RT) DMBMUWZ MT DTT DMBMUWZ MA Modulator DMBMUWZ RN Nat Rev Drug Discov. 2013 Feb;12(2):87-90. DMBMUWZ RU https://pubmed.ncbi.nlm.nih.gov/23370234 DMBMUWZ DI DMBMUWZ DMBMUWZ DN Emtricitabine DMBMUWZ MI DTZGT0P DMBMUWZ MN Multidrug and toxin extrusion protein 1 (SLC47A1) DMBMUWZ MT DTP DMBMUWZ MA Substrate DMBMUWZ RN Emtricitabine is a substrate of MATE1 but not of OCT1, OCT2, P-gp, BCRP or MRP2 transporters. Xenobiotica. 2017 Jan;47(1):77-85. DMBMUWZ RU http://www.ncbi.nlm.nih.gov/pubmed/27052107 DMNFUZR DI DMNFUZR DMNFUZR DN Enalapril DMNFUZR MI TTL69WB DMNFUZR MN Angiotensin-converting enzyme (ACE) DMNFUZR MT DTT DMNFUZR MA Inhibitor DMNFUZR RN Determination of bezafibrate, methotrexate, cyclophosphamide, orlistat and enalapril in waste and surface waters using on-line solid-phase extracti... J Environ Monit. 2009 Apr;11(4):830-8. DMNFUZR RU https://pubmed.ncbi.nlm.nih.gov/19557238 DMNFUZR DI DMNFUZR DMNFUZR DN Enalapril DMNFUZR MI DEB30C5 DMNFUZR MN Carboxylesterase 1 (CES1) DMNFUZR MT DME DMNFUZR MA Metabolism DMNFUZR RN Absorption and cleavage of enalapril, a carboxyl ester prodrug, in the rat intestine: in vitro, in situ intestinal perfusion and portal vein cannulation models. Biopharm Drug Dispos. 2015 Sep;36(6):385-397. DMNFUZR RU https://www.ncbi.nlm.nih.gov/pubmed/?term=25832562 DMNFUZR DI DMNFUZR DMNFUZR DN Enalapril DMNFUZR MI DE4LYSA DMNFUZR MN Cytochrome P450 3A4 (CYP3A4) DMNFUZR MT DME DMNFUZR MA Metabolism DMNFUZR RN Summary of information on human CYP enzymes: human P450 metabolism data. Drug Metab Rev. 2002 Feb-May;34(1-2):83-448. DMNFUZR RU https://www.ncbi.nlm.nih.gov/pubmed/?term=11996015 DMNFUZR DI DMNFUZR DMNFUZR DN Enalapril DMNFUZR MI DEQMBHW DMNFUZR MN Dipeptidase (pepV) DMNFUZR MT DME DMNFUZR MA Metabolism DMNFUZR RN Characterization and kinetic analysis of enzyme-substrate recognition by three recombinant lactococcal PepVs. Arch Biochem Biophys. 2006 Oct 15;454(2):137-45. DMNFUZR RU https://pubmed.ncbi.nlm.nih.gov/16962986 DMNFUZR DI DMNFUZR DMNFUZR DN Enalapril DMNFUZR MI DTFI42L DMNFUZR MN Multidrug resistance-associated protein 2 (ABCC2) DMNFUZR MT DTP DMNFUZR MA Substrate DMNFUZR RN Vectorial transport of enalapril by Oatp1a1/Mrp2 and OATP1B1 and OATP1B3/MRP2 in rat and human livers. J Pharmacol Exp Ther. 2006 Jul;318(1):395-402. DMNFUZR RU http://www.ncbi.nlm.nih.gov/pubmed/16627748 DMNFUZR DI DMNFUZR DMNFUZR DN Enalapril DMNFUZR MI DTE2B1D DMNFUZR MN Organic anion transporting polypeptide 1A2 (SLCO1A2) DMNFUZR MT DTP DMNFUZR MA Substrate DMNFUZR RN Uptake of enalapril and expression of organic anion transporting polypeptide 1 in zonal, isolated rat hepatocytes. Drug Metab Dispos. 2000 Jul;28(7):801-6. DMNFUZR RU http://www.ncbi.nlm.nih.gov/pubmed/10859154 DMNFUZR DI DMNFUZR DMNFUZR DN Enalapril DMNFUZR MI DT3D8F0 DMNFUZR MN Organic anion transporting polypeptide 1B1 (SLCO1B1) DMNFUZR MT DTP DMNFUZR MA Substrate DMNFUZR RN The modified dipeptide, enalapril, an angiotensin-converting enzyme inhibitor, is transported by the rat liver organic anion transport protein. Hepatology. 1998 Nov;28(5):1341-6. DMNFUZR RU http://www.ncbi.nlm.nih.gov/pubmed/9794920 DMNFUZR DI DMNFUZR DMNFUZR DN Enalapril DMNFUZR MI DT9C1TS DMNFUZR MN Organic anion transporting polypeptide 1B3 (SLCO1B3) DMNFUZR MT DTP DMNFUZR MA Substrate DMNFUZR RN Vectorial transport of enalapril by Oatp1a1/Mrp2 and OATP1B1 and OATP1B3/MRP2 in rat and human livers. J Pharmacol Exp Ther. 2006 Jul;318(1):395-402. DMNFUZR RU http://www.ncbi.nlm.nih.gov/pubmed/16627748 DMNFUZR DI DMNFUZR DMNFUZR DN Enalapril DMNFUZR MI DT9G7XN DMNFUZR MN Peptide transporter 1 (SLC15A1) DMNFUZR MT DTP DMNFUZR MA Substrate DMNFUZR RN The intestinal H+/peptide symporter PEPT1: structure-affinity relationships. Eur J Pharm Sci. 2004 Jan;21(1):53-60. DMNFUZR RU https://doi.org/10.1016/S0928-0987(03)00142-8 DMNFUZR DI DMNFUZR DMNFUZR DN Enalapril DMNFUZR MI DT8QKNP DMNFUZR MN Peptide transporter 2 (SLC15A2) DMNFUZR MT DTP DMNFUZR MA Substrate DMNFUZR RN Ethanol inhibits functional activity of the human intestinal dipeptide transporter hPepT1 expressed in Xenopus oocytes. Alcohol Clin Exp Res. 2008 May;32(5):777-84. DMNFUZR RU http://www.ncbi.nlm.nih.gov/pubmed/18336632 DMPRBQV DI DMPRBQV DMPRBQV DN Enalaprilat DMPRBQV MI TTL69WB DMPRBQV MN Angiotensin-converting enzyme (ACE) DMPRBQV MT DTT DMPRBQV MA Inhibitor DMPRBQV RN Analysis of Vancomycin in the Hindlimb Vascular Bed of the Rat. Am J Ther. 1996 Oct;3(10):681-687. DMPRBQV RU https://pubmed.ncbi.nlm.nih.gov/11862223 DMFYAM1 DI DMFYAM1 DMFYAM1 DN Enalaprilat DMFYAM1 MI DEQMBHW DMFYAM1 MN Dipeptidase (pepV) DMFYAM1 MT DME DMFYAM1 MA Metabolism DMFYAM1 RN Characterization and kinetic analysis of enzyme-substrate recognition by three recombinant lactococcal PepVs. Arch Biochem Biophys. 2006 Oct 15;454(2):137-45. DMFYAM1 RU https://pubmed.ncbi.nlm.nih.gov/16962986 DMPRBQV DI DMPRBQV DMPRBQV DN Enalaprilat DMPRBQV MI DT9G7XN DMPRBQV MN Peptide transporter 1 (SLC15A1) DMPRBQV MT DTP DMPRBQV MA Substrate DMPRBQV RN Transporter-mediated Drug Interactions. Drug Metab Pharmacokinet. 2002;17(4):253-74. DMPRBQV RU https://doi.org/10.2133/dmpk.17.253 DM8QXOC DI DM8QXOC DM8QXOC DN Enasidenib DM8QXOC MI DEJGDUW DM8QXOC MN Cytochrome P450 1A2 (CYP1A2) DM8QXOC MT DME DM8QXOC MA Metabolism DM8QXOC RN FDA Label of Enasidenib. The 2020 official website of the U.S. Food and Drug Administration. DM8QXOC RU https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/209606s000lbl.pdf DM8QXOC DI DM8QXOC DM8QXOC DN Enasidenib DM8QXOC MI DEPKLMQ DM8QXOC MN Cytochrome P450 2B6 (CYP2B6) DM8QXOC MT DME DM8QXOC MA Metabolism DM8QXOC RN FDA Label of Enasidenib. The 2020 official website of the U.S. Food and Drug Administration. DM8QXOC RU https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/209606s000lbl.pdf DM8QXOC DI DM8QXOC DM8QXOC DN Enasidenib DM8QXOC MI DES5XRU DM8QXOC MN Cytochrome P450 2C8 (CYP2C8) DM8QXOC MT DME DM8QXOC MA Metabolism DM8QXOC RN FDA Label of Enasidenib. The 2020 official website of the U.S. Food and Drug Administration. DM8QXOC RU https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/209606s000lbl.pdf DM8QXOC DI DM8QXOC DM8QXOC DN Enasidenib DM8QXOC MI DE5IED8 DM8QXOC MN Cytochrome P450 2C9 (CYP2C9) DM8QXOC MT DME DM8QXOC MA Metabolism DM8QXOC RN FDA Label of Enasidenib. The 2020 official website of the U.S. Food and Drug Administration. DM8QXOC RU https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/209606s000lbl.pdf DM8QXOC DI DM8QXOC DM8QXOC DN Enasidenib DM8QXOC MI DEGTFWK DM8QXOC MN Mephenytoin 4-hydroxylase (CYP2C19) DM8QXOC MT DME DM8QXOC MA Metabolism DM8QXOC RN Enasidenib for the treatment of acute myeloid leukemia. Expert Rev Clin Pharmacol. 2018 Aug;11(8):755-760. DM8QXOC RU https://www.ncbi.nlm.nih.gov/pubmed/?term=29770715 DMPOU5H DI DMPOU5H DMPOU5H DN ENASIDENIB MESYLATE DMPOU5H MI TTDTWV0 DMPOU5H MN Isocitrate dehydrogenase (IDH) DMPOU5H MT DTT DMPOU5H MA Inhibitor DMPOU5H RN 2017 FDA drug approvals.Nat Rev Drug Discov. 2018 Feb;17(2):81-85. DMPOU5H RU https://pubmed.ncbi.nlm.nih.gov/29348678 DM7RNP3 DI DM7RNP3 DM7RNP3 DN Enbrel DM7RNP3 MI TTF8CQI DM7RNP3 MN Tumor necrosis factor (TNF) DM7RNP3 MT DTT DM7RNP3 MA Modulator DM7RNP3 RN Oral pentoxifylline inhibits release of tumor necrosis factor-alpha from human peripheral blood monocytes : a potential treatment for aseptic loose... J Bone Joint Surg Am. 2001 Jul;83(7):1057-61. DM7RNP3 RU https://www.ncbi.nlm.nih.gov/pubmed/11451976 DM0YJSB DI DM0YJSB DM0YJSB DN Enflurane DM0YJSB MI DEVDYN7 DM0YJSB MN Cytochrome P450 2E1 (CYP2E1) DM0YJSB MT DME DM0YJSB MA Metabolism DM0YJSB RN Stereoselective metabolism of enflurane by human liver cytochrome P450 2E1. Drug Metab Dispos. 1995 Dec;23(12):1426-30. DM0YJSB RU https://www.ncbi.nlm.nih.gov/pubmed/?term=8689955 DM0YJSB DI DM0YJSB DM0YJSB DN Enflurane DM0YJSB MI DED5AT3 DM0YJSB MN Cytochrome P450 2F1 (CYP2F1) DM0YJSB MT DME DM0YJSB MA Metabolism DM0YJSB RN Clinical enflurane metabolism by cytochrome P450 2E1. Clin Pharmacol Ther. 1994 Apr;55(4):434-40. DM0YJSB RU https://www.ncbi.nlm.nih.gov/pubmed/?term=8162670 DM0YJSB DI DM0YJSB DM0YJSB DN Enflurane DM0YJSB MI TTAN6JD DM0YJSB MN Glutamate receptor AMPA (GRIA) DM0YJSB MT DTT DM0YJSB MA Suppressor DM0YJSB RN Enflurane directly depresses glutamate AMPA and NMDA currents in mouse spinal cord motor neurons independent of actions on GABAA or glycine receptors. Anesthesiology. 2000 Oct;93(4):1075-84. DM0YJSB RU https://pubmed.ncbi.nlm.nih.gov/11020764 DMFS63G DI DMFS63G DMFS63G DN Enfortumab DMFS63G MI TTPO9EG DMFS63G MN Nectin cell adhesion molecule 4 (NECTIN4) DMFS63G MT DTT DMFS63G MA Inhibitor DMFS63G RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health Human Services. 2019 DMFS63G RU https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/761137s000lbl.pdf DM7YPM1 DI DM7YPM1 DM7YPM1 DN Enfuvirtide DM7YPM1 MI DEVDYN7 DM7YPM1 MN Cytochrome P450 2E1 (CYP2E1) DM7YPM1 MT DME DM7YPM1 MA Metabolism DM7YPM1 RN Pharmacokinetics, pharmacodynamics and drug interaction potential of enfuvirtide. Clin Pharmacokinet. 2005;44(2):175-86. DM7YPM1 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=15656696 DM7YPM1 DI DM7YPM1 DM7YPM1 DN Enfuvirtide DM7YPM1 MI TTG90S6 DM7YPM1 MN Human immunodeficiency virus Glycoprotein 41 (HIV gp41) DM7YPM1 MT DTT DM7YPM1 MA Modulator DM7YPM1 RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. DM7YPM1 RU https://www.fda.gov/ DM7YPM1 DI DM7YPM1 DM7YPM1 DN Enfuvirtide DM7YPM1 MI DEGTFWK DM7YPM1 MN Mephenytoin 4-hydroxylase (CYP2C19) DM7YPM1 MT DME DM7YPM1 MA Metabolism DM7YPM1 RN Pharmacokinetics, pharmacodynamics and drug interaction potential of enfuvirtide. Clin Pharmacokinet. 2005;44(2):175-86. DM7YPM1 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=15656696 DMYTE6L DI DMYTE6L DMYTE6L DN Enoxacin DMYTE6L MI TT0IHXV DMYTE6L MN DNA topoisomerase II (TOP2) DMYTE6L MT DTT DMYTE6L MA Inhibitor DMYTE6L RN Clinical pharmacokinetics of the newer antibacterial 4-quinolones. Clin Pharmacokinet. 1988 Feb;14(2):96-121. DMYTE6L RU https://pubmed.ncbi.nlm.nih.gov/3282749 DMYTE6L DI DMYTE6L DMYTE6L DN Enoxacin DMYTE6L MI DTZGT0P DMYTE6L MN Multidrug and toxin extrusion protein 1 (SLC47A1) DMYTE6L MT DTP DMYTE6L MA Substrate DMYTE6L RN Functional characterization of multidrug and toxin extrusion protein 1 as a facilitative transporter for fluoroquinolones. J Pharmacol Exp Ther. 2009 Feb;328(2):628-34. DMYTE6L RU http://www.ncbi.nlm.nih.gov/pubmed/19004926 DMYTE6L DI DMYTE6L DMYTE6L DN Enoxacin DMYTE6L MI DTE2B1D DMYTE6L MN Organic anion transporting polypeptide 1A2 (SLCO1A2) DMYTE6L MT DTP DMYTE6L MA Substrate DMYTE6L RN Identification of influx transporter for the quinolone antibacterial agent levofloxacin. Mol Pharm. 2007 Jan-Feb;4(1):85-94. DMYTE6L RU http://www.ncbi.nlm.nih.gov/pubmed/17274666 DMQVZJD DI DMQVZJD DMQVZJD DN Enoximone DMQVZJD MI TTZCG4L DMQVZJD MN Phosphodiesterase 3 (PDE3) DMQVZJD MT DTT DMQVZJD MA Modulator DMQVZJD RN In vitro and in vivo effects of the phosphodiesterase-III inhibitor enoximone on malignant hyperthermia-susceptible swine. Anesthesiology. 2003 Apr;98(4):944-9. DMQVZJD RU https://www.ncbi.nlm.nih.gov/pubmed/12657857 DMQVZJD DI DMQVZJD DMQVZJD DN Enoximone DMQVZJD MI TT06AWU DMQVZJD MN Phosphodiesterase 3A (PDE3A) DMQVZJD MT DTT DMQVZJD MA Inhibitor DMQVZJD RN Inhibitors of cyclic AMP phosphodiesterase. 2. Structural variations of N-cyclohexyl-N-methyl-4-[(1,2,3,5-tetrahydro- 2-oxoimidazo[2,1-b]quinazolin... J Med Chem. 1987 Feb;30(2):303-18. DMQVZJD RU https://pubmed.ncbi.nlm.nih.gov/3027339 DMFYZKN DI DMFYZKN DMFYZKN DN Enprofylline DMFYZKN MI TTZ97H5 DMFYZKN MN Phosphodiesterase 4A (PDE4A) DMFYZKN MT DTT DMFYZKN MA Inhibitor DMFYZKN RN Effects of enprofylline, a new xanthine derivate, on human pregnant myometrium. Am J Obstet Gynecol. 1987 Apr;156(4):958-62. DMFYZKN RU https://pubmed.ncbi.nlm.nih.gov/3034059 DMLBVKQ DI DMLBVKQ DMLBVKQ DN Entacapone DMLBVKQ MI DTI7UX6 DMLBVKQ MN Breast cancer resistance protein (ABCG2) DMLBVKQ MT DTP DMLBVKQ MA Substrate DMLBVKQ RN Elucidation of the Impact of P-glycoprotein and Breast Cancer Resistance Protein on the Brain Distribution of Catechol-O-Methyltransferase Inhibitors. Drug Metab Dispos. 2017 Dec;45(12):1282-1291. DMLBVKQ RU http://www.ncbi.nlm.nih.gov/pubmed/28916530 DMLBVKQ DI DMLBVKQ DMLBVKQ DN Entacapone DMLBVKQ MI TTKWFB8 DMLBVKQ MN Catechol-O-methyl-transferase (COMT) DMLBVKQ MT DTT DMLBVKQ MA Inhibitor DMLBVKQ RN Entacapone: a catechol-O-methyltransferase inhibitor for the adjunctive treatment of Parkinson's disease. Clin Ther. 2001 Jun;23(6):802-32; discussion 771. DMLBVKQ RU https://pubmed.ncbi.nlm.nih.gov/11440283 DMLBVKQ DI DMLBVKQ DMLBVKQ DN Entacapone DMLBVKQ MI DT3D8F0 DMLBVKQ MN Organic anion transporting polypeptide 1B1 (SLCO1B1) DMLBVKQ MT DTP DMLBVKQ MA Substrate DMLBVKQ RN Organic Anion Transporter 2-Mediated Hepatic Uptake Contributes to the Clearance of High-Permeability-Low-Molecular-Weight Acid and Zwitterion Drugs: Evaluation Using 25 Drugs. J Pharmacol Exp Ther. 2018 Nov;367(2):322-334. DMLBVKQ RU http://www.ncbi.nlm.nih.gov/pubmed/30135178 DMLBVKQ DI DMLBVKQ DMLBVKQ DN Entacapone DMLBVKQ MI DE85D2P DMLBVKQ MN UDP-glucuronosyltransferase 1A9 (UGT1A9) DMLBVKQ MT DME DMLBVKQ MA Metabolism DMLBVKQ RN Kinetic characterization of the 1A subfamily of recombinant human UDP-glucuronosyltransferases. Drug Metab Dispos. 2005 Jul;33(7):1017-26. DMLBVKQ RU https://www.ncbi.nlm.nih.gov/pubmed/?term=15802387 DM7VTQO DI DM7VTQO DM7VTQO DN Entecavir DM7VTQO MI DTI7UX6 DM7VTQO MN Breast cancer resistance protein (ABCG2) DM7VTQO MT DTP DM7VTQO MA Substrate DM7VTQO RN Multiple SLC and ABC Transporters Contribute to the Placental Transfer of Entecavir. Drug Metab Dispos. 2017 Mar;45(3):269-278. DM7VTQO RU http://www.ncbi.nlm.nih.gov/pubmed/28062543 DM7VTQO DI DM7VTQO DM7VTQO DN Entecavir DM7VTQO MI DT4YL5R DM7VTQO MN Concentrative Na(+)-nucleoside cotransporter 3 (SLC28A3) DM7VTQO MT DTP DM7VTQO MA Substrate DM7VTQO RN Multiple SLC and ABC Transporters Contribute to the Placental Transfer of Entecavir. Drug Metab Dispos. 2017 Mar;45(3):269-278. DM7VTQO RU http://www.ncbi.nlm.nih.gov/pubmed/28062543 DM7VTQO DI DM7VTQO DM7VTQO DN Entecavir DM7VTQO MI DT82KPY DM7VTQO MN Concentrative nucleoside transporter 2 (SLC28A2) DM7VTQO MT DTP DM7VTQO MA Substrate DM7VTQO RN Multiple SLC and ABC Transporters Contribute to the Placental Transfer of Entecavir. Drug Metab Dispos. 2017 Mar;45(3):269-278. DM7VTQO RU http://www.ncbi.nlm.nih.gov/pubmed/28062543 DM7VTQO DI DM7VTQO DM7VTQO DN Entecavir DM7VTQO MI DTXD1TQ DM7VTQO MN Equilibrative nucleoside transporter 1 (SLC29A1) DM7VTQO MT DTP DM7VTQO MA Substrate DM7VTQO RN Multiple SLC and ABC Transporters Contribute to the Placental Transfer of Entecavir. Drug Metab Dispos. 2017 Mar;45(3):269-278. DM7VTQO RU http://www.ncbi.nlm.nih.gov/pubmed/28062543 DM7VTQO DI DM7VTQO DM7VTQO DN Entecavir DM7VTQO MI DTW78DQ DM7VTQO MN Equilibrative nucleoside transporter 2 (SLC29A2) DM7VTQO MT DTP DM7VTQO MA Substrate DM7VTQO RN Multiple SLC and ABC Transporters Contribute to the Placental Transfer of Entecavir. Drug Metab Dispos. 2017 Mar;45(3):269-278. DM7VTQO RU http://www.ncbi.nlm.nih.gov/pubmed/28062543 DM7VTQO DI DM7VTQO DM7VTQO DN Entecavir DM7VTQO MI TTS5K1M DM7VTQO MN Hepatitis B virus Reverse transcriptase (HBV RT) DM7VTQO MT DTT DM7VTQO MA Modulator DM7VTQO RN Effect of hepatitis B virus reverse transcriptase variations on entecavir treatment response. J Infect Dis. 2014 Sep 1;210(5):701-7. DM7VTQO RU https://pubmed.ncbi.nlm.nih.gov/24610871 DM7VTQO DI DM7VTQO DM7VTQO DN Entecavir DM7VTQO MI DT0OC1Q DM7VTQO MN Organic anion transporter 2 (SLC22A7) DM7VTQO MT DTP DM7VTQO MA Substrate DM7VTQO RN Human organic anion transporter 2 is an entecavir, but not tenofovir, transporter. Drug Metab Pharmacokinet. 2017 Feb;32(1):116-119. DM7VTQO RU http://www.ncbi.nlm.nih.gov/pubmed/27916488 DM7VTQO DI DM7VTQO DM7VTQO DN Entecavir DM7VTQO MI DT6201N DM7VTQO MN Organic cation transporter 3 (SLC22A3) DM7VTQO MT DTP DM7VTQO MA Substrate DM7VTQO RN Multiple SLC and ABC Transporters Contribute to the Placental Transfer of Entecavir. Drug Metab Dispos. 2017 Mar;45(3):269-278. DM7VTQO RU http://www.ncbi.nlm.nih.gov/pubmed/28062543 DM7VTQO DI DM7VTQO DM7VTQO DN Entecavir DM7VTQO MI DT3HUVD DM7VTQO MN Organic cation/carnitine transporter 2 (SLC22A5) DM7VTQO MT DTP DM7VTQO MA Substrate DM7VTQO RN Multiple SLC and ABC Transporters Contribute to the Placental Transfer of Entecavir. Drug Metab Dispos. 2017 Mar;45(3):269-278. DM7VTQO RU http://www.ncbi.nlm.nih.gov/pubmed/28062543 DM7VTQO DI DM7VTQO DM7VTQO DN Entecavir DM7VTQO MI DT8QKNP DM7VTQO MN Peptide transporter 2 (SLC15A2) DM7VTQO MT DTP DM7VTQO MA Substrate DM7VTQO RN The oligopeptide transporter 2-mediated reabsorption of entecavir in rat kidney. Eur J Pharm Sci. 2014 Feb 14;52:41-7. DM7VTQO RU http://www.ncbi.nlm.nih.gov/pubmed/24184752 DMK659W DI DMK659W DMK659W DN Enteric-coated mycophenolate sodium DMK659W MI TTCAQMW DMK659W MN Inosine-5'-monophosphate dehydrogenase (IMPDH) DMK659W MT DTT DMK659W MA Inhibitor DMK659W RN Mycophenolate mofetil, an inhibitor of inosine monophosphate dehydrogenase, causes a paradoxical elevation of GTP in erythrocytes of renal transplant patients. Clin Sci (Lond). 2004 Jul;107(1):63-8. DMK659W RU https://pubmed.ncbi.nlm.nih.gov/14723604 DMMPTLH DI DMMPTLH DMMPTLH DN Entrectinib DMMPTLH MI TTPMQSO DMMPTLH MN ALK tyrosine kinase receptor (ALK) DMMPTLH MT DTT DMMPTLH MA Inhibitor DMMPTLH RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health Human Services. 2019 DMMPTLH RU https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/212725s000lbl.pdf DMMPTLH DI DMMPTLH DMMPTLH DN Entrectinib DMMPTLH MI TTKN7QR DMMPTLH MN BDNF/NT-3 growth factors receptor (TrkB) DMMPTLH MT DTT DMMPTLH MA Inhibitor DMMPTLH RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health Human Services. 2019 DMMPTLH RU https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/212725s000lbl.pdf DMMPTLH DI DMMPTLH DMMPTLH DN Entrectinib DMMPTLH MI DE4LYSA DMMPTLH MN Cytochrome P450 3A4 (CYP3A4) DMMPTLH MT DME DMMPTLH MA Metabolism DMMPTLH RN Entrectinib: first global approval. Drugs. 2019 Sep;79(13):1477-1483. DMMPTLH RU https://www.ncbi.nlm.nih.gov/pubmed/?term=31372957 DMMPTLH DI DMMPTLH DMMPTLH DN Entrectinib DMMPTLH MI TTXABCW DMMPTLH MN NT-3 growth factor receptor (TrkC) DMMPTLH MT DTT DMMPTLH MA Inhibitor DMMPTLH RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health Human Services. 2019 DMMPTLH RU https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/212725s000lbl.pdf DMMPTLH DI DMMPTLH DMMPTLH DN Entrectinib DMMPTLH MI TTSZ6Y3 DMMPTLH MN Proto-oncogene c-Ros (ROS1) DMMPTLH MT DTT DMMPTLH MA Inhibitor DMMPTLH RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health Human Services. 2019 DMMPTLH RU https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/212725s000lbl.pdf DMMPTLH DI DMMPTLH DMMPTLH DN Entrectinib DMMPTLH MI TTTDVOJ DMMPTLH MN Tropomyosin-related kinase A (TrkA) DMMPTLH MT DTT DMMPTLH MA Inhibitor DMMPTLH RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health Human Services. 2019 DMMPTLH RU https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/212725s000lbl.pdf DMGL19D DI DMGL19D DMGL19D DN Enzalutamide DMGL19D MI TTS64P2 DMGL19D MN Androgen receptor (AR) DMGL19D MT DTT DMGL19D MA Modulator DMGL19D RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015 DMGL19D RU https://www.accessdata.fda.gov/scripts/cder/drugsatfda/ DM5OGK0 DI DM5OGK0 DM5OGK0 DN Epalrestat DM5OGK0 MI TTFBNVI DM5OGK0 MN Aldose reductase (AKR1B1) DM5OGK0 MT DTT DM5OGK0 MA Inhibitor DM5OGK0 RN Long-term effect of epalrestat, an aldose reductase inhibitor, on the development of incipient diabetic nephropathy in Type 2 diabetic patients. J Diabetes Complications. 2001 Sep-Oct;15(5):241-4. DM5OGK0 RU https://pubmed.ncbi.nlm.nih.gov/11522497 DM5OGK0 DI DM5OGK0 DM5OGK0 DN Epalrestat DM5OGK0 MI TTXHYV6 DM5OGK0 MN Voltage-gated L-type calcium channel (L-CaC) DM5OGK0 MT DTT DM5OGK0 MA Blocker DM5OGK0 RN Recent updates of N-type calcium channel blockers with therapeutic potential for neuropathic pain and stroke. Curr Top Med Chem. 2009;9(4):377-95. DM5OGK0 RU https://pubmed.ncbi.nlm.nih.gov/19442208 DMHEAGL DI DMHEAGL DMHEAGL DN Epanova DMHEAGL MI DE87OZS DMHEAGL MN Arachidonate 5-lipoxygenase (ALOX5) DMHEAGL MT DME DMHEAGL MA Metabolism DMHEAGL RN Omega-3 fatty acids and inflammatory processes. Nutrients. 2010 Mar;2(3):355-74. DMHEAGL RU https://www.ncbi.nlm.nih.gov/pubmed/?term=22254027 DMHEAGL DI DMHEAGL DMHEAGL DN Epanova DMHEAGL MI DEIPST6 DMHEAGL MN Cytochrome P450 147G1 (cyp147) DMHEAGL MT DME DMHEAGL MA Metabolism DMHEAGL RN Selective Omega-1 oxidation of fatty acids by CYP147G1 from Mycobacterium marinum. Biochim Biophys Acta Gen Subj. 2019 Feb;1863(2):408-417. DMHEAGL RU https://pubmed.ncbi.nlm.nih.gov/30476524 DMHEAGL DI DMHEAGL DMHEAGL DN Epanova DMHEAGL MI DE492CE DMHEAGL MN Prostaglandin G/H synthase 2 (COX-2) DMHEAGL MT DME DMHEAGL MA Metabolism DMHEAGL RN Structural basis of fatty acid substrate binding to cyclooxygenase-2. J Biol Chem. 2010 Jul 16;285(29):22152-63. DMHEAGL RU https://www.ncbi.nlm.nih.gov/pubmed/?term=20463020 DMMV0KW DI DMMV0KW DMMV0KW DN Ephedrine DMMV0KW MI TTEX248 DMMV0KW MN Dopamine D2 receptor (D2R) DMMV0KW MT DTT DMMV0KW MA Agonist DMMV0KW RN The effect of alpha-2 adrenergic agonists on memory and cognitive flexibility. Cogn Behav Neurol. 2006 Dec;19(4):204-7. DMMV0KW RU https://pubmed.ncbi.nlm.nih.gov/17159617 DMMV0KW DI DMMV0KW DMMV0KW DN Ephedrine DMMV0KW MI DEYWLRK DMMV0KW MN Sulfotransferase 1A1 (SULT1A1) DMMV0KW MT DME DMMV0KW MA Metabolism DMMV0KW RN Benzylic alcohols as stereospecific substrates and inhibitors for aryl sulfotransferase. Chirality. 1991;3(2):104-11. DMMV0KW RU https://www.ncbi.nlm.nih.gov/pubmed/?term=1863522 DMVONE6 DI DMVONE6 DMVONE6 DN Epidermal growth factor DMVONE6 MI DE1TNRG DMVONE6 MN Carboxypeptidase M (CPM) DMVONE6 MT DME DMVONE6 MA Metabolism DMVONE6 RN Extracellular conversion of epidermal growth factor (EGF) to des-Arg53-EGF by carboxypeptidase M. J Biol Chem. 1995 Jul 21;270(29):17154-8. DMVONE6 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=7615511 DMVONE6 DI DMVONE6 DMVONE6 DN Epidermal growth factor DMVONE6 MI TTED8JB DMVONE6 MN Epidermal growth factor (EGF) DMVONE6 MT DTT DMVONE6 MA Modulator DMVONE6 RN Repurposing of the epidermal growth factor. Journal of Commercial Biotechnology (2011) 17, 45-52. DMVONE6 RU http://www.palgrave-journals.com/jcb/journal/v17/n1/full/jcb201028a.html DMVONE6 DI DMVONE6 DMVONE6 DN Epidermal growth factor DMVONE6 MI TTGKNB4 DMVONE6 MN Epidermal growth factor receptor (EGFR) DMVONE6 MT DTT DMVONE6 MA Modulator DMVONE6 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1797). DMVONE6 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1797 DMX0K3Q DI DMX0K3Q DMX0K3Q DN Epinastine DMX0K3Q MI DEPKLMQ DMX0K3Q MN Cytochrome P450 2B6 (CYP2B6) DMX0K3Q MT DME DMX0K3Q MA Metabolism DMX0K3Q RN Metabolism of epinastine, a histamine H1 receptor antagonist, in human liver microsomes in comparison with that of terfenadine. Res Commun Mol Pathol Pharmacol. 1997 Dec;98(3):273-92. DMX0K3Q RU https://www.ncbi.nlm.nih.gov/pubmed/?term=9485522 DMX0K3Q DI DMX0K3Q DMX0K3Q DN Epinastine DMX0K3Q MI DECB0K3 DMX0K3Q MN Cytochrome P450 2D6 (CYP2D6) DMX0K3Q MT DME DMX0K3Q MA Metabolism DMX0K3Q RN Metabolism of epinastine, a histamine H1 receptor antagonist, in human liver microsomes in comparison with that of terfenadine. Res Commun Mol Pathol Pharmacol. 1997 Dec;98(3):273-92. DMX0K3Q RU https://www.ncbi.nlm.nih.gov/pubmed/?term=9485522 DMX0K3Q DI DMX0K3Q DMX0K3Q DN Epinastine DMX0K3Q MI DE4LYSA DMX0K3Q MN Cytochrome P450 3A4 (CYP3A4) DMX0K3Q MT DME DMX0K3Q MA Metabolism DMX0K3Q RN Metabolism of epinastine, a histamine H1 receptor antagonist, in human liver microsomes in comparison with that of terfenadine. Res Commun Mol Pathol Pharmacol. 1997 Dec;98(3):273-92. DMX0K3Q RU https://www.ncbi.nlm.nih.gov/pubmed/?term=9485522 DMX0K3Q DI DMX0K3Q DMX0K3Q DN Epinastine DMX0K3Q MI TTTIBOJ DMX0K3Q MN Histamine H1 receptor (H1R) DMX0K3Q MT DTT DMX0K3Q MA Antagonist DMX0K3Q RN Influence of epinastine hydrochloride, an H1-receptor antagonist, on the function of mite allergen-pulsed murine bone marrow-derived dendritic cell... Mediators Inflamm. 2009;2009:738038. DMX0K3Q RU https://pubmed.ncbi.nlm.nih.gov/19381339 DMX0K3Q DI DMX0K3Q DMX0K3Q DN Epinastine DMX0K3Q MI DTUGYRD DMX0K3Q MN P-glycoprotein 1 (ABCB1) DMX0K3Q MT DTP DMX0K3Q MA Substrate DMX0K3Q RN Influx and efflux transport of H1-antagonist epinastine across the blood-brain barrier. Drug Metab Dispos. 2004 May;32(5):519-24. DMX0K3Q RU https://doi.org/10.1124/dmd.32.5.519 DM3KJBC DI DM3KJBC DM3KJBC DN Epinephrine DM3KJBC MI TTR6W5O DM3KJBC MN Adrenergic receptor beta-1 (ADRB1) DM3KJBC MT DTT DM3KJBC MA Agonist DM3KJBC RN Adrenergic activation of electrogenic K+ secretion in guinea pig distal colonic epithelium: involvement of beta1- and beta2-adrenergic receptors. Am J Physiol Gastrointest Liver Physiol. 2009 Aug;297(2):G269-77. DM3KJBC RU https://pubmed.ncbi.nlm.nih.gov/19460844 DM3KJBC DI DM3KJBC DM3KJBC DN Epinephrine DM3KJBC MI DEV3T4A DM3KJBC MN Catechol O-methyltransferase (COMT) DM3KJBC MT DME DM3KJBC MA Metabolism DM3KJBC RN Different metabolism of norepinephrine and epinephrine by catechol-O-methyltransferase and monoamine oxidase in rats. J Pharmacol Exp Ther. 1994 Mar;268(3):1242-51. DM3KJBC RU https://www.ncbi.nlm.nih.gov/pubmed/?term=8138937 DM3KJBC DI DM3KJBC DM3KJBC DN Epinephrine DM3KJBC MI DERE4TU DM3KJBC MN Monoamine oxidase type A (MAO-A) DM3KJBC MT DME DM3KJBC MA Metabolism DM3KJBC RN Role of monoamine-oxidase-A-gene variation in the development of glioblastoma in males: a case control study. J Neurooncol. 2019 Nov;145(2):287-294. DM3KJBC RU https://www.ncbi.nlm.nih.gov/pubmed/?term=31556016 DM3KJBC DI DM3KJBC DM3KJBC DN Epinephrine DM3KJBC MI DTT79CX DM3KJBC MN Organic cation transporter 1 (SLC22A1) DM3KJBC MT DTP DM3KJBC MA Substrate DM3KJBC RN Human intestinal transporter database: QSAR modeling and virtual profiling of drug uptake, efflux and interactions. Pharm Res. 2013 Apr;30(4):996-1007. DM3KJBC RU https://doi.org/10.1007/s11095-012-0935-x DM3KJBC DI DM3KJBC DM3KJBC DN Epinephrine DM3KJBC MI DT6201N DM3KJBC MN Organic cation transporter 3 (SLC22A3) DM3KJBC MT DTP DM3KJBC MA Substrate DM3KJBC RN Differential pharmacological in vitro properties of organic cation transporters and regional distribution in rat brain. Neuropharmacology. 2006 Jun;50(8):941-52. DM3KJBC RU http://www.ncbi.nlm.nih.gov/pubmed/16581093 DM3KJBC DI DM3KJBC DM3KJBC DN Epinephrine DM3KJBC MI DEYWLRK DM3KJBC MN Sulfotransferase 1A1 (SULT1A1) DM3KJBC MT DME DM3KJBC MA Metabolism DM3KJBC RN Crystal structure of human sulfotransferase SULT1A3 in complex with dopamine and 3'-phosphoadenosine 5'-phosphate. Biochem Biophys Res Commun. 2005 Sep 23;335(2):417-23. DM3KJBC RU https://www.ncbi.nlm.nih.gov/pubmed/?term=16083857 DM3KJBC DI DM3KJBC DM3KJBC DN Epinephrine DM3KJBC MI DEFQ8VO DM3KJBC MN Thiopurine methyltransferase (TPMT) DM3KJBC MT DME DM3KJBC MA Metabolism DM3KJBC RN Adrenal catecholamines and their metabolism in the vitamin A deficient rat. Ann Nutr Metab. 1983;27(3):220-7. DM3KJBC RU https://www.ncbi.nlm.nih.gov/pubmed/?term=6859813 DM3KJBC DI DM3KJBC DM3KJBC DN Epinephrine DM3KJBC MI DEYGVN4 DM3KJBC MN UDP-glucuronosyltransferase 1A1 (UGT1A1) DM3KJBC MT DME DM3KJBC MA Metabolism DM3KJBC RN Steroid glucuronides: human circulatory levels and formation by LNCaP cells. J Steroid Biochem Mol Biol. 1991;40(4-6):593-8. DM3KJBC RU https://www.ncbi.nlm.nih.gov/pubmed/?term=1835648 DMPDW6T DI DMPDW6T DMPDW6T DN Epirubicin DMPDW6T MI DTI7UX6 DMPDW6T MN Breast cancer resistance protein (ABCG2) DMPDW6T MT DTP DMPDW6T MA Substrate DMPDW6T RN Mammalian drug efflux transporters of the ATP binding cassette (ABC) family in multidrug resistance: A review of the past decade. Cancer Lett. 2016 Jan 1;370(1):153-64. DMPDW6T RU http://www.ncbi.nlm.nih.gov/pubmed/26499806 DMPDW6T DI DMPDW6T DMPDW6T DN Epirubicin DMPDW6T MI TT0IHXV DMPDW6T MN DNA topoisomerase II (TOP2) DMPDW6T MT DTT DMPDW6T MA Modulator DMPDW6T RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. DMPDW6T RU https://www.fda.gov/ DMPDW6T DI DMPDW6T DMPDW6T DN Epirubicin DMPDW6T MI DTSYQGK DMPDW6T MN Multidrug resistance-associated protein 1 (ABCC1) DMPDW6T MT DTP DMPDW6T MA Substrate DMPDW6T RN Sulindac sulfide selectively increases sensitivity of ABCC1 expressing tumor cells to doxorubicin and glutathione depletion. J Biomed Res. 2016 Mar;30(2):120-133. DMPDW6T RU http://www.ncbi.nlm.nih.gov/pubmed/28276667 DMPDW6T DI DMPDW6T DMPDW6T DN Epirubicin DMPDW6T MI DTFI42L DMPDW6T MN Multidrug resistance-associated protein 2 (ABCC2) DMPDW6T MT DTP DMPDW6T MA Substrate DMPDW6T RN Mammalian drug efflux transporters of the ATP binding cassette (ABC) family in multidrug resistance: A review of the past decade. Cancer Lett. 2016 Jan 1;370(1):153-64. DMPDW6T RU http://www.ncbi.nlm.nih.gov/pubmed/26499806 DMPDW6T DI DMPDW6T DMPDW6T DN Epirubicin DMPDW6T MI DTUGYRD DMPDW6T MN P-glycoprotein 1 (ABCB1) DMPDW6T MT DTP DMPDW6T MA Substrate DMPDW6T RN Mammalian drug efflux transporters of the ATP binding cassette (ABC) family in multidrug resistance: A review of the past decade. Cancer Lett. 2016 Jan 1;370(1):153-64. DMPDW6T RU http://www.ncbi.nlm.nih.gov/pubmed/26499806 DMPDW6T DI DMPDW6T DMPDW6T DN Epirubicin DMPDW6T MI DEB3CV1 DMPDW6T MN UDP-glucuronosyltransferase 2B7 (UGT2B7) DMPDW6T MT DME DMPDW6T MA Metabolism DMPDW6T RN Epirubicin glucuronidation and UGT2B7 developmental expression. Drug Metab Dispos. 2006 Dec;34(12):2097-101. DMPDW6T RU https://www.ncbi.nlm.nih.gov/pubmed/?term=16985101 DMF0NQR DI DMF0NQR DMF0NQR DN Eplerenone DMF0NQR MI DE4LYSA DMF0NQR MN Cytochrome P450 3A4 (CYP3A4) DMF0NQR MT DME DMF0NQR MA Metabolism DMF0NQR RN Eplerenone: a selective aldosterone receptor antagonist for hypertension and heart failure. Heart Dis. 2003 Sep-Oct;5(5):354-63. DMF0NQR RU https://www.ncbi.nlm.nih.gov/pubmed/?term=14503934 DMF0NQR DI DMF0NQR DMF0NQR DN Eplerenone DMF0NQR MI DEIBDNY DMF0NQR MN Cytochrome P450 3A5 (CYP3A5) DMF0NQR MT DME DMF0NQR MA Metabolism DMF0NQR RN The relative role of CYP3A4 and CYP3A5 in eplerenone metabolism. Toxicol Lett. 2019 Oct 15;315:9-13. DMF0NQR RU https://www.ncbi.nlm.nih.gov/pubmed/?term=31408697 DMF0NQR DI DMF0NQR DMF0NQR DN Eplerenone DMF0NQR MI TT26PHO DMF0NQR MN Mineralocorticoid receptor (MR) DMF0NQR MT DTT DMF0NQR MA Modulator DMF0NQR RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. DMF0NQR RU https://www.fda.gov/ DMKWB73 DI DMKWB73 DMKWB73 DN Epoetin alfa DMKWB73 MI TTAUX24 DMKWB73 MN Erythropoietin Receptor (EPOR) DMKWB73 MT DTT DMKWB73 MA Agonist DMKWB73 RN 2007 Standards, Options, and Recommendations: use of erythropoiesis-stimulating agents (ESA: epoetin alfa, epoetin beta, and darbepoetin) for the management of anemia in children with cancer. PediatrBlood Cancer. 2009 Jul;53(1):7-12. DMKWB73 RU https://pubmed.ncbi.nlm.nih.gov/19229970 DMUTYR2 DI DMUTYR2 DMUTYR2 DN Epoprostenol DMUTYR2 MI DE5IED8 DMUTYR2 MN Cytochrome P450 2C9 (CYP2C9) DMUTYR2 MT DME DMUTYR2 MA Metabolism DMUTYR2 RN Cytochrome P4502C9-derived epoxyeicosatrienoic acids induce the expression of cyclooxygenase-2 in endothelial cells. Arterioscler Thromb Vasc Biol. 2005 Feb;25(2):321-6. DMUTYR2 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=15569819 DMUTYR2 DI DMUTYR2 DMUTYR2 DN Epoprostenol DMUTYR2 MI TTOFYT1 DMUTYR2 MN Prostacyclin receptor (PTGIR) DMUTYR2 MT DTT DMUTYR2 MA Agonist DMUTYR2 RN Novel signaling pathways promote a paracrine wave of prostacyclin-induced vascular smooth muscle differentiation. J Mol Cell Cardiol. 2009 May;46(5):682-94. DMUTYR2 RU https://pubmed.ncbi.nlm.nih.gov/19302827 DM07K2I DI DM07K2I DM07K2I DN Eprosartan DM07K2I MI TT8DBY3 DM07K2I MN Angiotensin II receptor type-1 (AGTR1) DM07K2I MT DTT DM07K2I MA Antagonist DM07K2I RN Clinical profile of eprosartan: a different angiotensin II receptor blocker. Cardiovasc Hematol Agents Med Chem. 2008 Oct;6(4):253-7. DM07K2I RU https://pubmed.ncbi.nlm.nih.gov/18855637 DM07K2I DI DM07K2I DM07K2I DN Eprosartan DM07K2I MI DT9G7XN DM07K2I MN Peptide transporter 1 (SLC15A1) DM07K2I MT DTP DM07K2I MA Substrate DM07K2I RN High-affinity interaction of sartans with H+/peptide transporters. Drug Metab Dispos. 2009 Jan;37(1):143-9. DM07K2I RU http://www.ncbi.nlm.nih.gov/pubmed/18824524 DMQXTJS DI DMQXTJS DMQXTJS DN Eptifibatide DMQXTJS MI TT38RM1 DMQXTJS MN Glycoprotein IIb/IIIa receptor (GPIIb/IIIa) DMQXTJS MT DTT DMQXTJS MA Modulator DMQXTJS RN Barbourin. A GPIIb-IIIa-specific integrin antagonist from the venom of Sistrurus m. barbouri. J Biol Chem. 1991 May 25;266(15):9359-62. DMQXTJS RU https://pubmed.ncbi.nlm.nih.gov/2033037 DM5LJCI DI DM5LJCI DM5LJCI DN Eptinezumab DM5LJCI MI TTAFORY DM5LJCI MN Calcitonin gene-related peptide (CALC) DM5LJCI MT DTT DM5LJCI MA Inhibitor DM5LJCI RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health Human Services. 2020 DM5LJCI RU https://www.accessdata.fda.gov/drugsatfda_docs/label/2020/761119s000lbl.pdf DMI782S DI DMI782S DMI782S DN Erdafitinib DMI782S MI DE5IED8 DMI782S MN Cytochrome P450 2C9 (CYP2C9) DMI782S MT DME DMI782S MA Metabolism DMI782S RN FDA label of Erdafitinib. The 2020 official website of the U.S. Food and Drug Administration. DMI782S RU https://www.accessdata.fda.gov/drugsatfda_docs/nda/2019/212018Orig1s000MultidisciplineR.pdf DMI782S DI DMI782S DMI782S DN Erdafitinib DMI782S MI DE4LYSA DMI782S MN Cytochrome P450 3A4 (CYP3A4) DMI782S MT DME DMI782S MA Metabolism DMI782S RN FDA label of Erdafitinib. The 2020 official website of the U.S. Food and Drug Administration. DMI782S RU https://www.accessdata.fda.gov/drugsatfda_docs/nda/2019/212018Orig1s000MultidisciplineR.pdf DMI782S DI DMI782S DMI782S DN Erdafitinib DMI782S MI TT0LF7H DMI782S MN Fibroblast growth factor receptor (FGFR) DMI782S MT DTT DMI782S MA Inhibitor DMI782S RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health Human Services. 2019 DMI782S RU https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/212018s000lbl.pdf DM6QFSV DI DM6QFSV DM6QFSV DN Erdosteine DM6QFSV MI TT3NKIB DM6QFSV MN Pancreatic elastase 1 (CELA1) DM6QFSV MT DTT DM6QFSV MA Modulator DM6QFSV RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015 DM6QFSV RU https://www.accessdata.fda.gov/scripts/cder/drugsatfda/ DMWMCN0 DI DMWMCN0 DMWMCN0 DN Erenumab DMWMCN0 MI TTY6O0Q DMWMCN0 MN Calcitonin gene-related peptide receptor (CGRPR) DMWMCN0 MT DTT DMWMCN0 MA Modulator DMWMCN0 RN 2018 FDA drug approvals.Nat Rev Drug Discov. 2019 Feb;18(2):85-89. DMWMCN0 RU https://pubmed.ncbi.nlm.nih.gov/30710142 DMHO0AR DI DMHO0AR DMHO0AR DN Ergocalciferol DMHO0AR MI DE98XPV DMHO0AR MN Cholesterol desmolase (CYP11A1) DMHO0AR MT DME DMHO0AR MA Metabolism DMHO0AR RN Vitamin D: mechanisms of action and clinical applications. Endocrinol Metab Clin North Am. 2017 Dec;46(4):xvii-xviii. DMHO0AR RU https://www.ncbi.nlm.nih.gov/pubmed/?term=29080648 DMHO0AR DI DMHO0AR DMHO0AR DN Ergocalciferol DMHO0AR MI DERSX5P DMHO0AR MN Cytochrome P450 2J2 (CYP2J2) DMHO0AR MT DME DMHO0AR MA Metabolism DMHO0AR RN Characterization of rat and human CYP2J enzymes as Vitamin D 25-hydroxylases. Steroids. 2006 Oct;71(10):849-56. DMHO0AR RU https://www.ncbi.nlm.nih.gov/pubmed/?term=16842832 DMHO0AR DI DMHO0AR DMHO0AR DN Ergocalciferol DMHO0AR MI DE4LYSA DMHO0AR MN Cytochrome P450 3A4 (CYP3A4) DMHO0AR MT DME DMHO0AR MA Metabolism DMHO0AR RN CYP3A4 is a human microsomal vitamin D 25-hydroxylase. J Bone Miner Res. 2004 Apr;19(4):680-8. DMHO0AR RU https://www.ncbi.nlm.nih.gov/pubmed/?term=15005856 DMHO0AR DI DMHO0AR DMHO0AR DN Ergocalciferol DMHO0AR MI DEBIHM3 DMHO0AR MN Vitamin D 25-hydroxylase (CYP2R1) DMHO0AR MT DME DMHO0AR MA Metabolism DMHO0AR RN CYP2R1 (vitamin D 25-hydroxylase) gene is associated with susceptibility to type 1 diabetes and vitamin D levels in Germans. Diabetes Metab Res Rev. 2007 Nov;23(8):631-6. DMHO0AR RU https://www.ncbi.nlm.nih.gov/pubmed/?term=17607662 DMHO0AR DI DMHO0AR DMHO0AR DN Ergocalciferol DMHO0AR MI TTK59TV DMHO0AR MN Vitamin D3 receptor (VDR) DMHO0AR MT DTT DMHO0AR MA Antagonist DMHO0AR RN Vitamin D in health and disease. Clin J Am Soc Nephrol. 2008 Sep;3(5):1535-41. DMHO0AR RU https://pubmed.ncbi.nlm.nih.gov/18525006 DMORPBA DI DMORPBA DMORPBA DN Ergoloid mesylate DMORPBA MI TT32XQJ DMORPBA MN Monoamine oxidase (MAO) DMORPBA MT DTT DMORPBA MA Modulator DMORPBA RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. DMORPBA RU https://www.fda.gov/ DM0VEC1 DI DM0VEC1 DM0VEC1 DN Ergonovine DM0VEC1 MI DE4LYSA DM0VEC1 MN Cytochrome P450 3A4 (CYP3A4) DM0VEC1 MT DME DM0VEC1 MA Metabolism DM0VEC1 RN Rational prescription of drugs within similar therapeutic or structural class for gastrointestinal disease treatment: drug metabolism and its related interactions. World J Gastroenterol. 2007 Nov 14;13(42):5618-28. DM0VEC1 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=17948937 DM0VEC1 DI DM0VEC1 DM0VEC1 DN Ergonovine DM0VEC1 MI TTEX248 DM0VEC1 MN Dopamine D2 receptor (D2R) DM0VEC1 MT DTT DM0VEC1 MA Agonist DM0VEC1 RN Agonist profile of ergometrine (ergonovine) on a population of postsynaptic alpha-adrenoceptors. J Pharm Pharmacol. 1988 Feb;40(2):137-9. DM0VEC1 RU https://pubmed.ncbi.nlm.nih.gov/2897449 DMKR3C5 DI DMKR3C5 DMKR3C5 DN Ergotamine DMKR3C5 MI TTG28O6 DMKR3C5 MN Adrenergic receptor Alpha-1 (ADRA1) DMKR3C5 MT DTT DMKR3C5 MA Agonist DMKR3C5 RN Reversal of ergotamine-induced vasospasm following methylprednisolone. Clin Toxicol (Phila). 2008 Dec;46(10):1074-6. DMKR3C5 RU https://pubmed.ncbi.nlm.nih.gov/18763151 DMKR3C5 DI DMKR3C5 DMKR3C5 DN Ergotamine DMKR3C5 MI DEJGDUW DMKR3C5 MN Cytochrome P450 1A2 (CYP1A2) DMKR3C5 MT DME DMKR3C5 MA Metabolism DMKR3C5 RN Frovatriptan: a review of drug-drug interactions. Headache. 2002 Apr;42 Suppl 2:S63-73. DMKR3C5 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=12028322 DMKR3C5 DI DMKR3C5 DMKR3C5 DN Ergotamine DMKR3C5 MI DE4LYSA DMKR3C5 MN Cytochrome P450 3A4 (CYP3A4) DMKR3C5 MT DME DMKR3C5 MA Metabolism DMKR3C5 RN Modulation of cytochrome P450 metabolism by ergonovine and dihydroergotamine. Vet Hum Toxicol. 2003 Feb;45(1):6-9. DMKR3C5 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=12583687 DMKR3C5 DI DMKR3C5 DMKR3C5 DN Ergotamine DMKR3C5 MI DTUGYRD DMKR3C5 MN P-glycoprotein 1 (ABCB1) DMKR3C5 MT DTP DMKR3C5 MA Substrate DMKR3C5 RN Improving the prediction of the brain disposition for orally administered drugs using BDDCS. Adv Drug Deliv Rev. 2012 Jan;64(1):95-109. DMKR3C5 RU https://doi.org/10.1016/j.addr.2011.12.008 DM78IME DI DM78IME DM78IME DN Ergotidine DM78IME MI DETECWH DM78IME MN Amiloride-sensitive amine oxidase (AOC1) DM78IME MT DME DM78IME MA Metabolism DM78IME RN Human kidney diamine oxidase: heterologous expression, purification, and characterization. J Biol Inorg Chem. 2002 Jun;7(6):565-79. DM78IME RU https://www.ncbi.nlm.nih.gov/pubmed/?term=12072962 DM78IME DI DM78IME DM78IME DN Ergotidine DM78IME MI DE5IED8 DM78IME MN Cytochrome P450 2C9 (CYP2C9) DM78IME MT DME DM78IME MA Metabolism DM78IME RN Atazanavir for the treatment of human immunodeficiency virus infection. Pharmacotherapy. 2004 Dec;24(12):1732-47. DM78IME RU https://www.ncbi.nlm.nih.gov/pubmed/?term=15585441 DM78IME DI DM78IME DM78IME DN Ergotidine DM78IME MI DE4LYSA DM78IME MN Cytochrome P450 3A4 (CYP3A4) DM78IME MT DME DM78IME MA Metabolism DM78IME RN Atazanavir for the treatment of human immunodeficiency virus infection. Pharmacotherapy. 2004 Dec;24(12):1732-47. DM78IME RU https://www.ncbi.nlm.nih.gov/pubmed/?term=15585441 DM78IME DI DM78IME DM78IME DN Ergotidine DM78IME MI DT3EAQP DM78IME MN Equilibrative nucleoside transporter 4 (SLC29A4) DM78IME MT DTP DM78IME MA Substrate DM78IME RN Histamine uptake mediated by plasma membrane monoamine transporter and organic cation transporters in rat mast cell lines. Eur J Pharmacol. 2019 Apr 15;849:75-83. DM78IME RU http://www.ncbi.nlm.nih.gov/pubmed/30707958 DM78IME DI DM78IME DM78IME DN Ergotidine DM78IME MI TTTIBOJ DM78IME MN Histamine H1 receptor (H1R) DM78IME MT DTT DM78IME MA Agonist DM78IME RN Cloning and pharmacological characterization of a fourth histamine receptor (H(4)) expressed in bone marrow. Mol Pharmacol. 2001 Mar;59(3):420-6. DM78IME RU https://pubmed.ncbi.nlm.nih.gov/11179434 DM78IME DI DM78IME DM78IME DN Ergotidine DM78IME MI DE3PZ0I DM78IME MN Histamine N-methyltransferase (HNMT) DM78IME MT DME DM78IME MA Metabolism DM78IME RN Histamine pharmacogenomics. Pharmacogenomics. 2009 May;10(5):867-83. DM78IME RU https://www.ncbi.nlm.nih.gov/pubmed/?term=19450133 DM78IME DI DM78IME DM78IME DN Ergotidine DM78IME MI DT9IDPW DM78IME MN Organic cation transporter 2 (SLC22A2) DM78IME MT DTP DM78IME MA Substrate DM78IME RN The organic cation transporters (OCT1, OCT2, EMT) and the plasma membrane monoamine transporter (PMAT) show differential distribution and cyclic expression pattern in human endometrium and early pregnancy decidua. Mol Reprod Dev. 2007 Oct;74(10):1303-11. DM78IME RU http://www.ncbi.nlm.nih.gov/pubmed/17393420 DM78IME DI DM78IME DM78IME DN Ergotidine DM78IME MI DT6201N DM78IME MN Organic cation transporter 3 (SLC22A3) DM78IME MT DTP DM78IME MA Substrate DM78IME RN Differential pharmacological in vitro properties of organic cation transporters and regional distribution in rat brain. Neuropharmacology. 2006 Jun;50(8):941-52. DM78IME RU http://www.ncbi.nlm.nih.gov/pubmed/16581093 DM78IME DI DM78IME DM78IME DN Ergotidine DM78IME MI DEFQ8VO DM78IME MN Thiopurine methyltransferase (TPMT) DM78IME MT DME DM78IME MA Metabolism DM78IME RN Histamine-N-methyl transferase polymorphism and risk for multiple sclerosis. Eur J Neurol. 2010 Feb;17(2):335-8. DM78IME RU https://www.ncbi.nlm.nih.gov/pubmed/?term=19538200 DM78IME DI DM78IME DM78IME DN Ergotidine DM78IME MI DTM953D DM78IME MN Vesicular amine transporter 1 (SLC18A1) DM78IME MT DTP DM78IME MA Substrate DM78IME RN Gastrin-producing endocrine cells: a novel source of histamine in the rat stomach. Endocrinology. 1998 Oct;139(10):4404-15. DM78IME RU http://www.ncbi.nlm.nih.gov/pubmed/9751525 DM78IME DI DM78IME DM78IME DN Ergotidine DM78IME MI DTT7VPB DM78IME MN Vesicular amine transporter 2 (SLC18A2) DM78IME MT DTP DM78IME MA Substrate DM78IME RN The vesicular monoamine transporter 2: an underexplored pharmacological target. Neurochem Int. 2014 Jul;73:89-97. DM78IME RU http://www.ncbi.nlm.nih.gov/pubmed/24398404 DM1DX4Q DI DM1DX4Q DM1DX4Q DN Eribulin DM1DX4Q MI DE4LYSA DM1DX4Q MN Cytochrome P450 3A4 (CYP3A4) DM1DX4Q MT DME DM1DX4Q MA Metabolism DM1DX4Q RN Delineation of the interactions between the chemotherapeutic agent eribulin mesylate (E7389) and human CYP3A4. Cancer Chemother Pharmacol. 2008 Sep;62(4):707-16. DM1DX4Q RU https://www.ncbi.nlm.nih.gov/pubmed/?term=18431572 DM1DX4Q DI DM1DX4Q DM1DX4Q DN Eribulin DM1DX4Q MI TTML2WA DM1DX4Q MN Tubulin (TUB) DM1DX4Q MT DTT DM1DX4Q MA Inhibitor DM1DX4Q RN Mullard A: 2010 FDA drug approvals. Nat Rev Drug Discov. 2011 Feb;10(2):82-5. DM1DX4Q RU https://pubmed.ncbi.nlm.nih.gov/21283092 DMCMBHA DI DMCMBHA DMCMBHA DN Erlotinib DMCMBHA MI DTI7UX6 DMCMBHA MN Breast cancer resistance protein (ABCG2) DMCMBHA MT DTP DMCMBHA MA Substrate DMCMBHA RN Functions of the breast cancer resistance protein (BCRP/ABCG2) in chemotherapy. Adv Drug Deliv Rev. 2009 Jan 31;61(1):26-33. DMCMBHA RU https://doi.org/10.1016/j.addr.2008.07.003 DMCMBHA DI DMCMBHA DMCMBHA DN Erlotinib DMCMBHA MI DEJGDUW DMCMBHA MN Cytochrome P450 1A2 (CYP1A2) DMCMBHA MT DME DMCMBHA MA Metabolism DMCMBHA RN Clinical pharmacokinetics of tyrosine kinase inhibitors. Cancer Treat Rev. 2009 Dec;35(8):692-706. DMCMBHA RU https://www.ncbi.nlm.nih.gov/pubmed/?term=19733976 DMCMBHA DI DMCMBHA DMCMBHA DN Erlotinib DMCMBHA MI DECB0K3 DMCMBHA MN Cytochrome P450 2D6 (CYP2D6) DMCMBHA MT DME DMCMBHA MA Metabolism DMCMBHA RN Clinical pharmacokinetics of tyrosine kinase inhibitors. Cancer Treat Rev. 2009 Dec;35(8):692-706. DMCMBHA RU https://www.ncbi.nlm.nih.gov/pubmed/?term=19733976 DMCMBHA DI DMCMBHA DMCMBHA DN Erlotinib DMCMBHA MI DE4LYSA DMCMBHA MN Cytochrome P450 3A4 (CYP3A4) DMCMBHA MT DME DMCMBHA MA Metabolism DMCMBHA RN In vitro assessment of time-dependent inhibitory effects on CYP2C8 and CYP3A activity by fourteen protein kinase inhibitors. Drug Metab Dispos. 2014 Jul;42(7):1202-9. DMCMBHA RU https://www.ncbi.nlm.nih.gov/pubmed/?term=24713129 DMCMBHA DI DMCMBHA DMCMBHA DN Erlotinib DMCMBHA MI DEIBDNY DMCMBHA MN Cytochrome P450 3A5 (CYP3A5) DMCMBHA MT DME DMCMBHA MA Metabolism DMCMBHA RN Clinical pharmacokinetics of tyrosine kinase inhibitors. Cancer Treat Rev. 2009 Dec;35(8):692-706. DMCMBHA RU https://www.ncbi.nlm.nih.gov/pubmed/?term=19733976 DMCMBHA DI DMCMBHA DMCMBHA DN Erlotinib DMCMBHA MI TTGKNB4 DMCMBHA MN Epidermal growth factor receptor (EGFR) DMCMBHA MT DTT DMCMBHA MA Inhibitor DMCMBHA RN Quantitative prediction of fold resistance for inhibitors of EGFR. Biochemistry. 2009 Sep 8;48(35):8435-48. DMCMBHA RU https://pubmed.ncbi.nlm.nih.gov/19627157 DMCMBHA DI DMCMBHA DMCMBHA DN Erlotinib DMCMBHA MI DTUGYRD DMCMBHA MN P-glycoprotein 1 (ABCB1) DMCMBHA MT DTP DMCMBHA MA Substrate DMCMBHA RN Effect of the ATP-binding cassette drug transporters ABCB1, ABCG2, and ABCC2 on erlotinib hydrochloride (Tarceva) disposition in in vitro and in vivo pharmacokinetic studies employing Bcrp1-/-/Mdr1a/1b-/- (triple-knockout) and wild-type mice. Mol Cancer Ther. 2008 Aug;7(8):2280-7. DMCMBHA RU https://doi.org/10.1158/1535-7163.MCT-07-2250 DM4S3O8 DI DM4S3O8 DM4S3O8 DN Ertapenem DM4S3O8 MI TTJP4SM DM4S3O8 MN Bacterial Penicillin binding protein (Bact PBP) DM4S3O8 MT DTT DM4S3O8 MA Binder DM4S3O8 RN Role of penicillin-binding protein 2 (PBP2) in the antibiotic susceptibility and cell wall cross-linking of Staphylococcus aureus: evidence for the cooperative functioning of PBP2, PBP4, and PBP2A. JBacteriol. 2005 Mar;187(5):1815-24. DM4S3O8 RU https://pubmed.ncbi.nlm.nih.gov/15716453 DM4S3O8 DI DM4S3O8 DM4S3O8 DN Ertapenem DM4S3O8 MI DEC3G7M DM4S3O8 MN Beta-lactamase (blaB) DM4S3O8 MT DME DM4S3O8 MA Metabolism DM4S3O8 RN FRI-4 carbapenemase-producing Enterobacter cloacae complex isolated in Tokyo, Japan. J Antimicrob Chemother. 2018 Nov 1;73(11):2969-2972. DM4S3O8 RU https://pubmed.ncbi.nlm.nih.gov/30060114 DM4S3O8 DI DM4S3O8 DM4S3O8 DN Ertapenem DM4S3O8 MI DEMIUB2 DM4S3O8 MN Beta-lactamase (blaB) DM4S3O8 MT DME DM4S3O8 MA Metabolism DM4S3O8 RN War wound treatment complications due to transfer of an IncN plasmid harboring bla(OXA-181) from Morganella morganii to CTX-M-27-producing sequence type 131 Escherichia coli. Antimicrob Agents Chemother. 2015;59(6):3556-62. DM4S3O8 RU https://pubmed.ncbi.nlm.nih.gov/25870058 DM4S3O8 DI DM4S3O8 DM4S3O8 DN Ertapenem DM4S3O8 MI DECWSA9 DM4S3O8 MN Beta-lactamase (blaB) DM4S3O8 MT DME DM4S3O8 MA Metabolism DM4S3O8 RN War wound treatment complications due to transfer of an IncN plasmid harboring bla(OXA-181) from Morganella morganii to CTX-M-27-producing sequence type 131 Escherichia coli. Antimicrob Agents Chemother. 2015;59(6):3556-62. DM4S3O8 RU https://pubmed.ncbi.nlm.nih.gov/25870058 DMFGQ2S DI DMFGQ2S DMFGQ2S DN Erythrityl Tetranitrate DMFGQ2S MI TT6HPVC DMFGQ2S MN Guanylate cyclase (GC) DMFGQ2S MT DTT DMFGQ2S MA Stimulator DMFGQ2S RN Nitric oxide and nitric oxide synthase isoforms in the normal, hypertrophic, and failing heart. Mol Cell Biochem. 2010 Jan;333(1-2):191-201. DMFGQ2S RU https://pubmed.ncbi.nlm.nih.gov/19618122 DM4K7GQ DI DM4K7GQ DM4K7GQ DN Erythromycin DM4K7GQ MI TTUWYEA DM4K7GQ MN Bacterial 50S ribosomal RNA (Bact 50S rRNA) DM4K7GQ MT DTT DM4K7GQ MA Binder DM4K7GQ RN A synthetic alanyl-initiator tRNA with initiator tRNA properties as determined by fluorescence measurements: comparison to a synthetic alanyl-elongator tRNA. Nucleic Acids Res. 1991 Oct 25;19(20):5749-54. DM4K7GQ RU https://pubmed.ncbi.nlm.nih.gov/1945852 DM4K7GQ DI DM4K7GQ DM4K7GQ DN Erythromycin DM4K7GQ MI DE7IQ34 DM4K7GQ MN Beta-glucuronidase (uidA) DM4K7GQ MT DME DM4K7GQ MA Metabolism DM4K7GQ RN Identification of Lactobacillus sakei genes induced during meat fermentation and their role in survival and growth. Appl Environ Microbiol. 2007 Apr;73(8):2522-31. DM4K7GQ RU https://pubmed.ncbi.nlm.nih.gov/17308175 DM4K7GQ DI DM4K7GQ DM4K7GQ DN Erythromycin DM4K7GQ MI DTI7UX6 DM4K7GQ MN Breast cancer resistance protein (ABCG2) DM4K7GQ MT DTP DM4K7GQ MA Substrate DM4K7GQ RN ABCG2: a perspective. Adv Drug Deliv Rev. 2009 Jan 31;61(1):3-13. DM4K7GQ RU https://doi.org/10.1016/j.addr.2008.11.003 DM4K7GQ DI DM4K7GQ DM4K7GQ DN Erythromycin DM4K7GQ MI DE6OQ3W DM4K7GQ MN Cytochrome P450 1A1 (CYP1A1) DM4K7GQ MT DME DM4K7GQ MA Metabolism DM4K7GQ RN Cytochromes P450 in crustacea. Comp Biochem Physiol C Pharmacol Toxicol Endocrinol. 1998 Nov;121(1-3):157-72. DM4K7GQ RU https://www.ncbi.nlm.nih.gov/pubmed/?term=9972457 DM4K7GQ DI DM4K7GQ DM4K7GQ DN Erythromycin DM4K7GQ MI DEJGDUW DM4K7GQ MN Cytochrome P450 1A2 (CYP1A2) DM4K7GQ MT DME DM4K7GQ MA Metabolism DM4K7GQ RN Comparative studies of in vitro inhibition of cytochrome P450 3A4-dependent testosterone 6beta-hydroxylation by roxithromycin and its metabolites, troleandomycin, and erythromycin. Drug Metab Dispos. 1998 Nov;26(11):1053-7. DM4K7GQ RU https://www.ncbi.nlm.nih.gov/pubmed/?term=9806945 DM4K7GQ DI DM4K7GQ DM4K7GQ DN Erythromycin DM4K7GQ MI DE9QHP6 DM4K7GQ MN Cytochrome P450 1B1 (CYP1B1) DM4K7GQ MT DME DM4K7GQ MA Metabolism DM4K7GQ RN Cytochromes P450 in crustacea. Comp Biochem Physiol C Pharmacol Toxicol Endocrinol. 1998 Nov;121(1-3):157-72. DM4K7GQ RU https://www.ncbi.nlm.nih.gov/pubmed/?term=9972457 DM4K7GQ DI DM4K7GQ DM4K7GQ DN Erythromycin DM4K7GQ MI DE4LYSA DM4K7GQ MN Cytochrome P450 3A4 (CYP3A4) DM4K7GQ MT DME DM4K7GQ MA Metabolism DM4K7GQ RN Effect of the CYP3A4 inhibitor erythromycin on the pharmacokinetics of lignocaine and its pharmacologically active metabolites in subjects with normal and impaired liver function. Br J Clin Pharmacol. 2003 Jan;55(1):86-93. DM4K7GQ RU https://www.ncbi.nlm.nih.gov/pubmed/?term=12534644 DM4K7GQ DI DM4K7GQ DM4K7GQ DN Erythromycin DM4K7GQ MI DEIBDNY DM4K7GQ MN Cytochrome P450 3A5 (CYP3A5) DM4K7GQ MT DME DM4K7GQ MA Metabolism DM4K7GQ RN Differential regulation of CYP3A4 and CYP3A5 and its implication in drug discovery. Curr Drug Metab. 2017;18(12):1095-1105. DM4K7GQ RU https://www.ncbi.nlm.nih.gov/pubmed/?term=28558634 DM4K7GQ DI DM4K7GQ DM4K7GQ DN Erythromycin DM4K7GQ MI DERD86B DM4K7GQ MN Cytochrome P450 3A7 (CYP3A7) DM4K7GQ MT DME DM4K7GQ MA Metabolism DM4K7GQ RN Helices F-G are important for the substrate specificities of CYP3A7. Drug Metab Dispos. 2007 Mar;35(3):484-92. DM4K7GQ RU https://www.ncbi.nlm.nih.gov/pubmed/?term=17178770 DM4K7GQ DI DM4K7GQ DM4K7GQ DN Erythromycin DM4K7GQ MI DEIZLTN DM4K7GQ MN Docosahexaenoic acid omega-hydroxylase (CYP4F11) DM4K7GQ MT DME DM4K7GQ MA Metabolism DM4K7GQ RN Expression and characterization of human cytochrome P450 4F11: putative role in the metabolism of therapeutic drugs and eicosanoids. Toxicol Appl Pharmacol. 2004 Sep 15;199(3):295-304. DM4K7GQ RU https://pubmed.ncbi.nlm.nih.gov/15364545 DM4K7GQ DI DM4K7GQ DM4K7GQ DN Erythromycin DM4K7GQ MI DTFI42L DM4K7GQ MN Multidrug resistance-associated protein 2 (ABCC2) DM4K7GQ MT DTP DM4K7GQ MA Substrate DM4K7GQ RN Effect of ABCC2 (MRP2) transport function on erythromycin metabolism. Clin Pharmacol Ther. 2011 May;89(5):693-701. DM4K7GQ RU http://www.ncbi.nlm.nih.gov/pubmed/21451505 DM4K7GQ DI DM4K7GQ DM4K7GQ DN Erythromycin DM4K7GQ MI DT0OC1Q DM4K7GQ MN Organic anion transporter 2 (SLC22A7) DM4K7GQ MT DTP DM4K7GQ MA Substrate DM4K7GQ RN Possible involvement of organic anion transporter 2 on the interaction of theophylline with erythromycin in the human liver. Drug Metab Dispos. 2005 May;33(5):619-22. DM4K7GQ RU http://www.ncbi.nlm.nih.gov/pubmed/15708966 DM4K7GQ DI DM4K7GQ DM4K7GQ DN Erythromycin DM4K7GQ MI DT9C1TS DM4K7GQ MN Organic anion transporting polypeptide 1B3 (SLCO1B3) DM4K7GQ MT DTP DM4K7GQ MA Substrate DM4K7GQ RN Impact of OATP transporters on pharmacokinetics. Br J Pharmacol. 2009 Oct;158(3):693-705. DM4K7GQ RU http://www.ncbi.nlm.nih.gov/pubmed/19785645 DM4K7GQ DI DM4K7GQ DM4K7GQ DN Erythromycin DM4K7GQ MI DTUGYRD DM4K7GQ MN P-glycoprotein 1 (ABCB1) DM4K7GQ MT DTP DM4K7GQ MA Substrate DM4K7GQ RN Enhanced corneal absorption of erythromycin by modulating P-glycoprotein and MRP mediated efflux with corticosteroids. Pharm Res. 2009 May;26(5):1270-82. DM4K7GQ RU http://www.ncbi.nlm.nih.gov/pubmed/18958406 DMFK9HG DI DMFK9HG DMFK9HG DN Escitalopram DMFK9HG MI DECB0K3 DMFK9HG MN Cytochrome P450 2D6 (CYP2D6) DMFK9HG MT DME DMFK9HG MA Metabolism DMFK9HG RN CYP2D6 P34S Polymorphism and Outcomes of Escitalopram Treatment in Koreans with Major Depression. Psychiatry Investig. 2013 Sep;10(3):286-93. DMFK9HG RU https://www.ncbi.nlm.nih.gov/pubmed/?term=24302953 DMFK9HG DI DMFK9HG DMFK9HG DN Escitalopram DMFK9HG MI DE4LYSA DMFK9HG MN Cytochrome P450 3A4 (CYP3A4) DMFK9HG MT DME DMFK9HG MA Metabolism DMFK9HG RN PharmGKB summary: citalopram pharmacokinetics pathway. Pharmacogenet Genomics. 2011 Nov;21(11):769-72. DMFK9HG RU https://www.ncbi.nlm.nih.gov/pubmed/?term=21546862 DMFK9HG DI DMFK9HG DMFK9HG DN Escitalopram DMFK9HG MI DEGTFWK DMFK9HG MN Mephenytoin 4-hydroxylase (CYP2C19) DMFK9HG MT DME DMFK9HG MA Metabolism DMFK9HG RN Escitalopram pharmacogenetics: CYP2C19 relationships with dosing and clinical outcomes in autism spectrum disorder. Pharmacogenet Genomics. 2015 Nov;25(11):548-54. DMFK9HG RU https://www.ncbi.nlm.nih.gov/pubmed/?term=26313485 DMFK9HG DI DMFK9HG DMFK9HG DN Escitalopram DMFK9HG MI TT3ROYC DMFK9HG MN Serotonin transporter (SERT) DMFK9HG MT DTT DMFK9HG MA Inhibitor DMFK9HG RN Antidepressants and sleep: a review. Perspect Psychiatr Care. 2009 Jul;45(3):191-7. DMFK9HG RU https://pubmed.ncbi.nlm.nih.gov/19566691 DMZREFQ DI DMZREFQ DMZREFQ DN Eslicarbazepine DMZREFQ MI TTRK8B9 DMZREFQ MN Sodium channel unspecific (NaC) DMZREFQ MT DTT DMZREFQ MA Blocker DMZREFQ RN Progress report on new antiepileptic drugs: a summary of the Ninth Eilat Conference (EILAT IX). Epilepsy Res. 2009 Jan;83(1):1-43. DMZREFQ RU https://pubmed.ncbi.nlm.nih.gov/19008076 DMZREFQ DI DMZREFQ DMZREFQ DN Eslicarbazepine DMZREFQ MI DEYGVN4 DMZREFQ MN UDP-glucuronosyltransferase 1A1 (UGT1A1) DMZREFQ MT DME DMZREFQ MA Metabolism DMZREFQ RN Hepatic UDP-glucuronosyltransferase is responsible for eslicarbazepine glucuronidation. Drug Metab Dispos. 2011 Sep;39(9):1486-94. DMZREFQ RU https://www.ncbi.nlm.nih.gov/pubmed/?term=21673130 DMZREFQ DI DMZREFQ DMZREFQ DN Eslicarbazepine DMZREFQ MI TTIG65Q DMZREFQ MN Voltage-gated sodium channel (Nav) DMZREFQ MT DTT DMZREFQ MA Inhibitor DMZREFQ RN Antibodies and venom peptides: new modalities for ion channels. Nat Rev Drug Discov. 2019 May;18(5):339-357. DMZREFQ RU https://pubmed.ncbi.nlm.nih.gov/30728472 DMZREFQ DI DMZREFQ DMZREFQ DN Eslicarbazepine DMZREFQ MI TTN9VTF DMZREFQ MN Voltage-gated sodium channel alpha Nav1.9 (SCN11A) DMZREFQ MT DTT DMZREFQ MA Inhibitor DMZREFQ RN Antibodies and venom peptides: new modalities for ion channels. Nat Rev Drug Discov. 2019 May;18(5):339-357. DMZREFQ RU https://pubmed.ncbi.nlm.nih.gov/30728472 DMREUZV DI DMREUZV DMREUZV DN Eslicarbazepine acetate DMREUZV MI DTUGYRD DMREUZV MN P-glycoprotein 1 (ABCB1) DMREUZV MT DTP DMREUZV MA Substrate DMREUZV RN In vitro transport profile of carbamazepine, oxcarbazepine, eslicarbazepine acetate, and their active metabolites by human P-glycoprotein. Epilepsia. 2011 Oct;52(10):1894-904. DMREUZV RU https://doi.org/10.1111/j.1528-1167.2011.03140.x DM51TYR DI DM51TYR DM51TYR DN Esmolol DM51TYR MI TTR6W5O DM51TYR MN Adrenergic receptor beta-1 (ADRB1) DM51TYR MT DTT DM51TYR MA Antagonist DM51TYR RN Beta-1 selective adrenergic antagonist landiolol and esmolol can be safely used in patients with airway hyperreactivity. Heart Lung. 2009 Jan-Feb;38(1):48-55. DM51TYR RU https://pubmed.ncbi.nlm.nih.gov/19150530 DM51TYR DI DM51TYR DM51TYR DN Esmolol DM51TYR MI DECB0K3 DM51TYR MN Cytochrome P450 2D6 (CYP2D6) DM51TYR MT DME DM51TYR MA Metabolism DM51TYR RN Application of substrate depletion assay to evaluation of CYP isoforms responsible for stereoselective metabolism of carvedilol. Drug Metab Pharmacokinet. 2016 Dec;31(6):425-432. DM51TYR RU https://www.ncbi.nlm.nih.gov/pubmed/?term=27836712 DM7BN0X DI DM7BN0X DM7BN0X DN Esomeprazole DM7BN0X MI TTLOKXP DM7BN0X MN Gastric H(+)/K(+) ATPase (Proton pump) DM7BN0X MT DTT DM7BN0X MA Modulator DM7BN0X RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. DM7BN0X RU https://www.fda.gov/ DM7BN0X DI DM7BN0X DM7BN0X DN Esomeprazole DM7BN0X MI DEGTFWK DM7BN0X MN Mephenytoin 4-hydroxylase (CYP2C19) DM7BN0X MT DME DM7BN0X MA Metabolism DM7BN0X RN Predictive performance of physiologically based pharmacokinetic (PBPK) modeling of drugs extensively metabolized by major cytochrome P450s in children. Clin Pharmacol Ther. 2018 Jul;104(1):188-200. DM7BN0X RU https://www.ncbi.nlm.nih.gov/pubmed/?term=29027194 DMZGXUM DI DMZGXUM DMZGXUM DN Estazolam DMZGXUM MI DE4LYSA DMZGXUM MN Cytochrome P450 3A4 (CYP3A4) DMZGXUM MT DME DMZGXUM MA Metabolism DMZGXUM RN Identification of human cytochrome P450 enzymes involved in the formation of 4-hydroxyestazolam from estazolam. Xenobiotica. 2005 May;35(5):455-65. DMZGXUM RU https://www.ncbi.nlm.nih.gov/pubmed/?term=16012077 DMZGXUM DI DMZGXUM DMZGXUM DN Estazolam DMZGXUM MI TTPTXIN DMZGXUM MN Translocator protein (TSPO) DMZGXUM MT DTT DMZGXUM MA Agonist DMZGXUM RN Design and synthesis of new 2-substituted-5-(2-benzylthiophenyl)-1,3,4-oxadiazoles as benzodiazepine receptor agonists. Bioorg Med Chem Lett. 2005 Jun 15;15(12):3126-9. DMZGXUM RU https://pubmed.ncbi.nlm.nih.gov/15876530 DM9KZDO DI DM9KZDO DM9KZDO DN Esterified estrogens DM9KZDO MI TTZAYWL DM9KZDO MN Estrogen receptor (ESR) DM9KZDO MT DTT DM9KZDO MA Modulator DM9KZDO RN Safety and efficacy of low-dose esterified estrogens and methyltestosterone, alone or combined, for the treatment of hot flashes in menopausal women: a randomized, double-blind, placebo-controlled study. Fertil Steril. 2011 Jan;95(1):366-8. DM9KZDO RU https://pubmed.ncbi.nlm.nih.gov/20850731 DMUNTE3 DI DMUNTE3 DMUNTE3 DN Estradiol DMUNTE3 MI DTI7UX6 DMUNTE3 MN Breast cancer resistance protein (ABCG2) DMUNTE3 MT DTP DMUNTE3 MA Substrate DMUNTE3 RN Sterol transport by the human breast cancer resistance protein (ABCG2) expressed in Lactococcus lactis. J Biol Chem. 2003 Jun 6;278(23):20645-51. DMUNTE3 RU http://www.ncbi.nlm.nih.gov/pubmed/12668685 DMUNTE3 DI DMUNTE3 DMUNTE3 DN Estradiol DMUNTE3 MI DE6OQ3W DMUNTE3 MN Cytochrome P450 1A1 (CYP1A1) DMUNTE3 MT DME DMUNTE3 MA Metabolism DMUNTE3 RN Cytochrome P450 isoforms catalyze formation of catechol estrogen quinones that react with DNA. Metabolism. 2007 Jul;56(7):887-94. DMUNTE3 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=17570247 DMUNTE3 DI DMUNTE3 DMUNTE3 DN Estradiol DMUNTE3 MI DEJGDUW DMUNTE3 MN Cytochrome P450 1A2 (CYP1A2) DMUNTE3 MT DME DMUNTE3 MA Metabolism DMUNTE3 RN Cytochrome P450 1A2 (CYP1A2) activity and risk factors for breast cancer: a cross-sectional study. Breast Cancer Res. 2004;6(4):R352-65. DMUNTE3 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=15217502 DMUNTE3 DI DMUNTE3 DMUNTE3 DN Estradiol DMUNTE3 MI DE9QHP6 DMUNTE3 MN Cytochrome P450 1B1 (CYP1B1) DMUNTE3 MT DME DMUNTE3 MA Metabolism DMUNTE3 RN Cytochrome P450 isoforms catalyze formation of catechol estrogen quinones that react with DNA. Metabolism. 2007 Jul;56(7):887-94. DMUNTE3 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=17570247 DMUNTE3 DI DMUNTE3 DMUNTE3 DN Estradiol DMUNTE3 MI DES5XRU DMUNTE3 MN Cytochrome P450 2C8 (CYP2C8) DMUNTE3 MT DME DMUNTE3 MA Metabolism DMUNTE3 RN Role of cytochrome P450 2C8 in drug metabolism and interactions. Pharmacol Rev. 2016 Jan;68(1):168-241. DMUNTE3 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=26721703 DMUNTE3 DI DMUNTE3 DMUNTE3 DN Estradiol DMUNTE3 MI DE5IED8 DMUNTE3 MN Cytochrome P450 2C9 (CYP2C9) DMUNTE3 MT DME DMUNTE3 MA Metabolism DMUNTE3 RN Characterization of the oxidative metabolites of 17beta-estradiol and estrone formed by 15 selectively expressed human cytochrome p450 isoforms. Endocrinology. 2003 Aug;144(8):3382-98. DMUNTE3 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=12865317 DMUNTE3 DI DMUNTE3 DMUNTE3 DN Estradiol DMUNTE3 MI DE4LYSA DMUNTE3 MN Cytochrome P450 3A4 (CYP3A4) DMUNTE3 MT DME DMUNTE3 MA Metabolism DMUNTE3 RN Isoform-specific regulation of cytochromes P450 expression by estradiol and progesterone. Drug Metab Dispos. 2013 Feb;41(2):263-9. DMUNTE3 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=22837389 DMUNTE3 DI DMUNTE3 DMUNTE3 DN Estradiol DMUNTE3 MI DEIBDNY DMUNTE3 MN Cytochrome P450 3A5 (CYP3A5) DMUNTE3 MT DME DMUNTE3 MA Metabolism DMUNTE3 RN Drug Interactions Flockhart Table DMUNTE3 RU https://drug-interactions.medicine.iu.edu/Main-Table.aspx DMUNTE3 DI DMUNTE3 DMUNTE3 DN Estradiol DMUNTE3 MI DERD86B DMUNTE3 MN Cytochrome P450 3A7 (CYP3A7) DMUNTE3 MT DME DMUNTE3 MA Metabolism DMUNTE3 RN Drug Interactions Flockhart Table DMUNTE3 RU https://drug-interactions.medicine.iu.edu/Main-Table.aspx DMUNTE3 DI DMUNTE3 DMUNTE3 DN Estradiol DMUNTE3 MI DEGTB1K DMUNTE3 MN Dehydrogenase/reductase retSDR3 (HSD17B14) DMUNTE3 MT DME DMUNTE3 MA Metabolism DMUNTE3 RN Expression patterns of 17beta-hydroxysteroid dehydrogenase 14 in human tissues. Horm Metab Res. 2012 Dec;44(13):949-56. DMUNTE3 RU https://pubmed.ncbi.nlm.nih.gov/22864907 DMUNTE3 DI DMUNTE3 DMUNTE3 DN Estradiol DMUNTE3 MI TTZAYWL DMUNTE3 MN Estrogen receptor (ESR) DMUNTE3 MT DTT DMUNTE3 MA Agonist DMUNTE3 RN Reprint of Are all estrogens the same Maturitas. 2008 Sep-Oct;61(1-2):195-201. DMUNTE3 RU https://pubmed.ncbi.nlm.nih.gov/19434891 DMUNTE3 DI DMUNTE3 DMUNTE3 DN Estradiol DMUNTE3 MI DER0XCH DMUNTE3 MN Farnesol dehydrogenase (AKR1B15) DMUNTE3 MT DME DMUNTE3 MA Metabolism DMUNTE3 RN Aldo-keto Reductase 1B15 (AKR1B15): a mitochondrial human aldo-keto reductase with activity toward steroids and 3-keto-acyl-CoA conjugates. J Biol Chem. 2015 Mar 6;290(10):6531-45. DMUNTE3 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=25577493 DMUNTE3 DI DMUNTE3 DMUNTE3 DN Estradiol DMUNTE3 MI DEHX1DZ DMUNTE3 MN Lactoperoxidase (LPO) DMUNTE3 MT DME DMUNTE3 MA Metabolism DMUNTE3 RN The metabolism of 17 beta-estradiol by lactoperoxidase: a possible source of oxidative stress in breast cancer. Carcinogenesis. 1994 Nov;15(11):2637-43. DMUNTE3 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=7955118 DMUNTE3 DI DMUNTE3 DMUNTE3 DN Estradiol DMUNTE3 MI DEGTFWK DMUNTE3 MN Mephenytoin 4-hydroxylase (CYP2C19) DMUNTE3 MT DME DMUNTE3 MA Metabolism DMUNTE3 RN CYP2C19*17 is associated with decreased breast cancer risk. Breast Cancer Res Treat. 2009 May;115(2):391-6. DMUNTE3 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=18521743 DMUNTE3 DI DMUNTE3 DMUNTE3 DN Estradiol DMUNTE3 MI DTUGYRD DMUNTE3 MN P-glycoprotein 1 (ABCB1) DMUNTE3 MT DTP DMUNTE3 MA Substrate DMUNTE3 RN Antiestrogens and steroid hormones: substrates of the human P-glycoprotein. Biochem Pharmacol. 1994 Jul 19;48(2):287-92. DMUNTE3 RU http://www.ncbi.nlm.nih.gov/pubmed/7914405 DMUNTE3 DI DMUNTE3 DMUNTE3 DN Estradiol DMUNTE3 MI DEYWLRK DMUNTE3 MN Sulfotransferase 1A1 (SULT1A1) DMUNTE3 MT DME DMUNTE3 MA Metabolism DMUNTE3 RN Proposed role of the sulfotransferase/sulfatase pathway in modulating yolk steroid effects. Integr Comp Biol. 2008 Sep;48(3):419-27. DMUNTE3 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=21669803 DMUNTE3 DI DMUNTE3 DMUNTE3 DN Estradiol DMUNTE3 MI DEFQ8VO DMUNTE3 MN Thiopurine methyltransferase (TPMT) DMUNTE3 MT DME DMUNTE3 MA Metabolism DMUNTE3 RN Influence of estradiol-17 beta and progesterone on catechol-O-methyltransferase and monoamine oxidase activities in uterine artery and myometrium of ovariectomized pigs. Arch Vet Pol. 1993;33(1-2):29-37. DMUNTE3 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=8055052 DMUNTE3 DI DMUNTE3 DMUNTE3 DN Estradiol DMUNTE3 MI DEYGVN4 DMUNTE3 MN UDP-glucuronosyltransferase 1A1 (UGT1A1) DMUNTE3 MT DME DMUNTE3 MA Metabolism DMUNTE3 RN Functional characterization of human and cynomolgus monkey UDP-glucuronosyltransferase 1A1 enzymes. Life Sci. 2010 Aug 14;87(7-8):261-8. DMUNTE3 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=20620155 DMUNTE3 DI DMUNTE3 DMUNTE3 DN Estradiol DMUNTE3 MI DEB7I4M DMUNTE3 MN UDP-glucuronosyltransferase 2B28 (UGT2B28) DMUNTE3 MT DME DMUNTE3 MA Metabolism DMUNTE3 RN Isolation and characterization of the UGT2B28 cDNA encoding a novel human steroid conjugating UDP-glucuronosyltransferase. Biochemistry. 2001 Apr 3;40(13):3869-81. DMUNTE3 RU https://pubmed.ncbi.nlm.nih.gov/11300766 DM07U2A DI DM07U2A DM07U2A DN Estradiol acetate DM07U2A MI DEJGDUW DM07U2A MN Cytochrome P450 1A2 (CYP1A2) DM07U2A MT DME DM07U2A MA Metabolism DM07U2A RN Characterization of the oxidative metabolites of 17beta-estradiol and estrone formed by 15 selectively expressed human cytochrome p450 isoforms. Endocrinology. 2003 Aug;144(8):3382-98. DM07U2A RU https://www.ncbi.nlm.nih.gov/pubmed/?term=12865317 DM07U2A DI DM07U2A DM07U2A DN Estradiol acetate DM07U2A MI DES5XRU DM07U2A MN Cytochrome P450 2C8 (CYP2C8) DM07U2A MT DME DM07U2A MA Metabolism DM07U2A RN Role of cytochrome P450 2C8 in drug metabolism and interactions. Pharmacol Rev. 2016 Jan;68(1):168-241. DM07U2A RU https://www.ncbi.nlm.nih.gov/pubmed/?term=26721703 DM07U2A DI DM07U2A DM07U2A DN Estradiol acetate DM07U2A MI DE5IED8 DM07U2A MN Cytochrome P450 2C9 (CYP2C9) DM07U2A MT DME DM07U2A MA Metabolism DM07U2A RN A potential role for the estrogen-metabolizing cytochrome P450 enzymes in human breast carcinogenesis. Breast Cancer Res Treat. 2003 Dec;82(3):191-7. DM07U2A RU https://www.ncbi.nlm.nih.gov/pubmed/?term=14703066 DM07U2A DI DM07U2A DM07U2A DN Estradiol acetate DM07U2A MI DE4LYSA DM07U2A MN Cytochrome P450 3A4 (CYP3A4) DM07U2A MT DME DM07U2A MA Metabolism DM07U2A RN A potential role for the estrogen-metabolizing cytochrome P450 enzymes in human breast carcinogenesis. Breast Cancer Res Treat. 2003 Dec;82(3):191-7. DM07U2A RU https://www.ncbi.nlm.nih.gov/pubmed/?term=14703066 DM07U2A DI DM07U2A DM07U2A DN Estradiol acetate DM07U2A MI DEIBDNY DM07U2A MN Cytochrome P450 3A5 (CYP3A5) DM07U2A MT DME DM07U2A MA Metabolism DM07U2A RN Drug Interactions Flockhart Table DM07U2A RU https://drug-interactions.medicine.iu.edu/Main-Table.aspx DM07U2A DI DM07U2A DM07U2A DN Estradiol acetate DM07U2A MI DERD86B DM07U2A MN Cytochrome P450 3A7 (CYP3A7) DM07U2A MT DME DM07U2A MA Metabolism DM07U2A RN Drug Interactions Flockhart Table DM07U2A RU https://drug-interactions.medicine.iu.edu/Main-Table.aspx DM07U2A DI DM07U2A DM07U2A DN Estradiol acetate DM07U2A MI TTZAYWL DM07U2A MN Estrogen receptor (ESR) DM07U2A MT DTT DM07U2A MA Modulator DM07U2A RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. DM07U2A RU https://www.fda.gov/ DM07U2A DI DM07U2A DM07U2A DN Estradiol acetate DM07U2A MI DEGTFWK DM07U2A MN Mephenytoin 4-hydroxylase (CYP2C19) DM07U2A MT DME DM07U2A MA Metabolism DM07U2A RN Role of cytochrome P450 in estradiol metabolism in vitro. Acta Pharmacol Sin. 2001 Feb;22(2):148-54. DM07U2A RU https://www.ncbi.nlm.nih.gov/pubmed/?term=11741520 DM07U2A DI DM07U2A DM07U2A DN Estradiol acetate DM07U2A MI DEYGVN4 DM07U2A MN UDP-glucuronosyltransferase 1A1 (UGT1A1) DM07U2A MT DME DM07U2A MA Metabolism DM07U2A RN Functional characterization of human and cynomolgus monkey UDP-glucuronosyltransferase 1A1 enzymes. Life Sci. 2010 Aug 14;87(7-8):261-8. DM07U2A RU https://www.ncbi.nlm.nih.gov/pubmed/?term=20620155 DM27Z5T DI DM27Z5T DM27Z5T DN Estradiol cypionate DM27Z5T MI DEJGDUW DM27Z5T MN Cytochrome P450 1A2 (CYP1A2) DM27Z5T MT DME DM27Z5T MA Metabolism DM27Z5T RN Inhibition of the human liver microsomal and human cytochrome P450 1A2 and 3A4 metabolism of estradiol by deployment-related and other chemicals. Drug Metab Dispos. 2006 Sep;34(9):1606-14. DM27Z5T RU https://www.ncbi.nlm.nih.gov/pubmed/?term=16790556 DM27Z5T DI DM27Z5T DM27Z5T DN Estradiol cypionate DM27Z5T MI DES5XRU DM27Z5T MN Cytochrome P450 2C8 (CYP2C8) DM27Z5T MT DME DM27Z5T MA Metabolism DM27Z5T RN Role of cytochrome P450 in estradiol metabolism in vitro. Acta Pharmacol Sin. 2001 Feb;22(2):148-54. DM27Z5T RU https://www.ncbi.nlm.nih.gov/pubmed/?term=11741520 DM27Z5T DI DM27Z5T DM27Z5T DN Estradiol cypionate DM27Z5T MI DE5IED8 DM27Z5T MN Cytochrome P450 2C9 (CYP2C9) DM27Z5T MT DME DM27Z5T MA Metabolism DM27Z5T RN A potential role for the estrogen-metabolizing cytochrome P450 enzymes in human breast carcinogenesis. Breast Cancer Res Treat. 2003 Dec;82(3):191-7. DM27Z5T RU https://www.ncbi.nlm.nih.gov/pubmed/?term=14703066 DM27Z5T DI DM27Z5T DM27Z5T DN Estradiol cypionate DM27Z5T MI DE4LYSA DM27Z5T MN Cytochrome P450 3A4 (CYP3A4) DM27Z5T MT DME DM27Z5T MA Metabolism DM27Z5T RN A potential role for the estrogen-metabolizing cytochrome P450 enzymes in human breast carcinogenesis. Breast Cancer Res Treat. 2003 Dec;82(3):191-7. DM27Z5T RU https://www.ncbi.nlm.nih.gov/pubmed/?term=14703066 DM27Z5T DI DM27Z5T DM27Z5T DN Estradiol cypionate DM27Z5T MI DEIBDNY DM27Z5T MN Cytochrome P450 3A5 (CYP3A5) DM27Z5T MT DME DM27Z5T MA Metabolism DM27Z5T RN Drug Interactions Flockhart Table DM27Z5T RU https://drug-interactions.medicine.iu.edu/Main-Table.aspx DM27Z5T DI DM27Z5T DM27Z5T DN Estradiol cypionate DM27Z5T MI DERD86B DM27Z5T MN Cytochrome P450 3A7 (CYP3A7) DM27Z5T MT DME DM27Z5T MA Metabolism DM27Z5T RN Drug Interactions Flockhart Table DM27Z5T RU https://drug-interactions.medicine.iu.edu/Main-Table.aspx DM27Z5T DI DM27Z5T DM27Z5T DN Estradiol cypionate DM27Z5T MI TTZAYWL DM27Z5T MN Estrogen receptor (ESR) DM27Z5T MT DTT DM27Z5T MA Modulator DM27Z5T RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. DM27Z5T RU https://www.fda.gov/ DM27Z5T DI DM27Z5T DM27Z5T DN Estradiol cypionate DM27Z5T MI DEGTFWK DM27Z5T MN Mephenytoin 4-hydroxylase (CYP2C19) DM27Z5T MT DME DM27Z5T MA Metabolism DM27Z5T RN Role of cytochrome P450 in estradiol metabolism in vitro. Acta Pharmacol Sin. 2001 Feb;22(2):148-54. DM27Z5T RU https://www.ncbi.nlm.nih.gov/pubmed/?term=11741520 DM27Z5T DI DM27Z5T DM27Z5T DN Estradiol cypionate DM27Z5T MI DEYGVN4 DM27Z5T MN UDP-glucuronosyltransferase 1A1 (UGT1A1) DM27Z5T MT DME DM27Z5T MA Metabolism DM27Z5T RN Functional characterization of human and cynomolgus monkey UDP-glucuronosyltransferase 1A1 enzymes. Life Sci. 2010 Aug 14;87(7-8):261-8. DM27Z5T RU https://www.ncbi.nlm.nih.gov/pubmed/?term=20620155 DM8MC6O DI DM8MC6O DM8MC6O DN Estradiol valerate DM8MC6O MI DEJGDUW DM8MC6O MN Cytochrome P450 1A2 (CYP1A2) DM8MC6O MT DME DM8MC6O MA Metabolism DM8MC6O RN Inhibition of the human liver microsomal and human cytochrome P450 1A2 and 3A4 metabolism of estradiol by deployment-related and other chemicals. Drug Metab Dispos. 2006 Sep;34(9):1606-14. DM8MC6O RU https://www.ncbi.nlm.nih.gov/pubmed/?term=16790556 DM8MC6O DI DM8MC6O DM8MC6O DN Estradiol valerate DM8MC6O MI DES5XRU DM8MC6O MN Cytochrome P450 2C8 (CYP2C8) DM8MC6O MT DME DM8MC6O MA Metabolism DM8MC6O RN Role of cytochrome P450 in estradiol metabolism in vitro. Acta Pharmacol Sin. 2001 Feb;22(2):148-54. DM8MC6O RU https://www.ncbi.nlm.nih.gov/pubmed/?term=11741520 DM8MC6O DI DM8MC6O DM8MC6O DN Estradiol valerate DM8MC6O MI DE5IED8 DM8MC6O MN Cytochrome P450 2C9 (CYP2C9) DM8MC6O MT DME DM8MC6O MA Metabolism DM8MC6O RN A potential role for the estrogen-metabolizing cytochrome P450 enzymes in human breast carcinogenesis. Breast Cancer Res Treat. 2003 Dec;82(3):191-7. DM8MC6O RU https://www.ncbi.nlm.nih.gov/pubmed/?term=14703066 DM8MC6O DI DM8MC6O DM8MC6O DN Estradiol valerate DM8MC6O MI DE4LYSA DM8MC6O MN Cytochrome P450 3A4 (CYP3A4) DM8MC6O MT DME DM8MC6O MA Metabolism DM8MC6O RN A potential role for the estrogen-metabolizing cytochrome P450 enzymes in human breast carcinogenesis. Breast Cancer Res Treat. 2003 Dec;82(3):191-7. DM8MC6O RU https://www.ncbi.nlm.nih.gov/pubmed/?term=14703066 DM8MC6O DI DM8MC6O DM8MC6O DN Estradiol valerate DM8MC6O MI DEIBDNY DM8MC6O MN Cytochrome P450 3A5 (CYP3A5) DM8MC6O MT DME DM8MC6O MA Metabolism DM8MC6O RN Drug Interactions Flockhart Table DM8MC6O RU https://drug-interactions.medicine.iu.edu/Main-Table.aspx DM8MC6O DI DM8MC6O DM8MC6O DN Estradiol valerate DM8MC6O MI DERD86B DM8MC6O MN Cytochrome P450 3A7 (CYP3A7) DM8MC6O MT DME DM8MC6O MA Metabolism DM8MC6O RN Drug Interactions Flockhart Table DM8MC6O RU https://drug-interactions.medicine.iu.edu/Main-Table.aspx DM8MC6O DI DM8MC6O DM8MC6O DN Estradiol valerate DM8MC6O MI TTZAYWL DM8MC6O MN Estrogen receptor (ESR) DM8MC6O MT DTT DM8MC6O MA Modulator DM8MC6O RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. DM8MC6O RU https://www.fda.gov/ DM8MC6O DI DM8MC6O DM8MC6O DN Estradiol valerate DM8MC6O MI DEGTFWK DM8MC6O MN Mephenytoin 4-hydroxylase (CYP2C19) DM8MC6O MT DME DM8MC6O MA Metabolism DM8MC6O RN Role of cytochrome P450 in estradiol metabolism in vitro. Acta Pharmacol Sin. 2001 Feb;22(2):148-54. DM8MC6O RU https://www.ncbi.nlm.nih.gov/pubmed/?term=11741520 DM8MC6O DI DM8MC6O DM8MC6O DN Estradiol valerate DM8MC6O MI DEYGVN4 DM8MC6O MN UDP-glucuronosyltransferase 1A1 (UGT1A1) DM8MC6O MT DME DM8MC6O MA Metabolism DM8MC6O RN Functional characterization of human and cynomolgus monkey UDP-glucuronosyltransferase 1A1 enzymes. Life Sci. 2010 Aug 14;87(7-8):261-8. DM8MC6O RU https://www.ncbi.nlm.nih.gov/pubmed/?term=20620155 DMLNMEA DI DMLNMEA DMLNMEA DN Estradiol valerate/dienogest DMLNMEA MI TTUV8G9 DMLNMEA MN Progesterone receptor (PGR) DMLNMEA MT DTT DMLNMEA MA Modulator DMLNMEA RN Mullard A: 2010 FDA drug approvals. Nat Rev Drug Discov. 2011 Feb;10(2):82-5. DMLNMEA RU https://pubmed.ncbi.nlm.nih.gov/21283092 DMWTAOI DI DMWTAOI DMWTAOI DN Estramustine DMWTAOI MI DE4LYSA DMWTAOI MN Cytochrome P450 3A4 (CYP3A4) DMWTAOI MT DME DMWTAOI MA Metabolism DMWTAOI RN Activity of docetaxel with or without estramustine phosphate versus mitoxantrone in androgen dependent and independent human prostate cancer xenografts. J Urol. 2003 May;169(5):1729-34. DMWTAOI RU https://www.ncbi.nlm.nih.gov/pubmed/?term=12686819 DMWTAOI DI DMWTAOI DMWTAOI DN Estramustine DMWTAOI MI TTSBFYK DMWTAOI MN Estramustine binding protein (EMBP) DMWTAOI MT DTT DMWTAOI MA Binder DMWTAOI RN Estramustine binding protein in primary tumours and metastases of malignant melanoma. Melanoma Res. 1994 Dec;4(6):401-5. DMWTAOI RU https://pubmed.ncbi.nlm.nih.gov/7703721 DMOEM2I DI DMOEM2I DMOEM2I DN Estriol DMOEM2I MI DERD86B DMOEM2I MN Cytochrome P450 3A7 (CYP3A7) DMOEM2I MT DME DMOEM2I MA Metabolism DMOEM2I RN Expression and cyclic variability of CYP3A4 and CYP3A7 isoforms in human endometrium and cervix during the menstrual cycle. Drug Metab Dispos. 2003 Jan;31(1):1-6. DMOEM2I RU https://www.ncbi.nlm.nih.gov/pubmed/?term=12485945 DMOEM2I DI DMOEM2I DMOEM2I DN Estriol DMOEM2I MI TTZAYWL DMOEM2I MN Estrogen receptor (ESR) DMOEM2I MT DTT DMOEM2I MA Agonist DMOEM2I RN Reprint of Are all estrogens the same Maturitas. 2008 Sep-Oct;61(1-2):195-201. DMOEM2I RU https://pubmed.ncbi.nlm.nih.gov/19434891 DMOEM2I DI DMOEM2I DMOEM2I DN Estriol DMOEM2I MI DTUGYRD DMOEM2I MN P-glycoprotein 1 (ABCB1) DMOEM2I MT DTP DMOEM2I MA Substrate DMOEM2I RN P-glycoprotein (P-gp/MDR1)-mediated efflux of sex-steroid hormones and modulation of P-gp expression in vitro. Pharm Res. 2004 Jul;21(7):1284-93. DMOEM2I RU http://www.ncbi.nlm.nih.gov/pubmed/15290871 DMOEM2I DI DMOEM2I DMOEM2I DN Estriol DMOEM2I MI DEYGVN4 DMOEM2I MN UDP-glucuronosyltransferase 1A1 (UGT1A1) DMOEM2I MT DME DMOEM2I MA Metabolism DMOEM2I RN Stimulation of microsomal uridine diphosphate glucuronyltransferase by glucuronic acid derivatives. Biochem J. 1974 Apr;139(1):243-9. DMOEM2I RU https://www.ncbi.nlm.nih.gov/pubmed/?term=4219139 DMGY0UT DI DMGY0UT DMGY0UT DN Estrogen DMGY0UT MI TTZAYWL DMGY0UT MN Estrogen receptor (ESR) DMGY0UT MT DTT DMGY0UT MA Agonist DMGY0UT RN Estrogen-receptor polymorphisms and effects of estrogen replacement on high-density lipoprotein cholesterol in women with coronary disease. N Engl J Med. 2002 Mar 28;346(13):967-74. DMGY0UT RU https://pubmed.ncbi.nlm.nih.gov/11919305 DMGY0UT DI DMGY0UT DMGY0UT DN Estrogen DMGY0UT MI TTOM3J0 DMGY0UT MN Estrogen receptor beta (ESR2) DMGY0UT MT DTT DMGY0UT MA Agonist DMGY0UT RN Estrogen inhibits the vascular injury response in estrogen receptor beta-deficient female mice. Proc Natl Acad Sci U S A. 1999 Dec 21;96(26):15133-6. DMGY0UT RU https://pubmed.ncbi.nlm.nih.gov/10611350 DM5T6US DI DM5T6US DM5T6US DN Estrone DM5T6US MI DE6OQ3W DM5T6US MN Cytochrome P450 1A1 (CYP1A1) DM5T6US MT DME DM5T6US MA Metabolism DM5T6US RN A common CYP1B1 polymorphism is associated with 2-OHE1/16-OHE1 urinary estrone ratio. Clin Chem Lab Med. 2005;43(7):702-6. DM5T6US RU https://www.ncbi.nlm.nih.gov/pubmed/?term=16207128 DM5T6US DI DM5T6US DM5T6US DN Estrone DM5T6US MI DEJGDUW DM5T6US MN Cytochrome P450 1A2 (CYP1A2) DM5T6US MT DME DM5T6US MA Metabolism DM5T6US RN A transgenic mouse expressing human CYP1A2 in the pancreas. Biochem Pharmacol. 2000 Sep 15;60(6):857-63. DM5T6US RU https://www.ncbi.nlm.nih.gov/pubmed/?term=10930541 DM5T6US DI DM5T6US DM5T6US DN Estrone DM5T6US MI DE9QHP6 DM5T6US MN Cytochrome P450 1B1 (CYP1B1) DM5T6US MT DME DM5T6US MA Metabolism DM5T6US RN A common CYP1B1 polymorphism is associated with 2-OHE1/16-OHE1 urinary estrone ratio. Clin Chem Lab Med. 2005;43(7):702-6. DM5T6US RU https://www.ncbi.nlm.nih.gov/pubmed/?term=16207128 DM5T6US DI DM5T6US DM5T6US DN Estrone DM5T6US MI DEPKLMQ DM5T6US MN Cytochrome P450 2B6 (CYP2B6) DM5T6US MT DME DM5T6US MA Metabolism DM5T6US RN Characterization of the oxidative metabolites of 17beta-estradiol and estrone formed by 15 selectively expressed human cytochrome p450 isoforms. Endocrinology. 2003 Aug;144(8):3382-98. DM5T6US RU https://www.ncbi.nlm.nih.gov/pubmed/?term=12865317 DM5T6US DI DM5T6US DM5T6US DN Estrone DM5T6US MI DE5IED8 DM5T6US MN Cytochrome P450 2C9 (CYP2C9) DM5T6US MT DME DM5T6US MA Metabolism DM5T6US RN A potential role for the estrogen-metabolizing cytochrome P450 enzymes in human breast carcinogenesis. Breast Cancer Res Treat. 2003 Dec;82(3):191-7. DM5T6US RU https://www.ncbi.nlm.nih.gov/pubmed/?term=14703066 DM5T6US DI DM5T6US DM5T6US DN Estrone DM5T6US MI DEVDYN7 DM5T6US MN Cytochrome P450 2E1 (CYP2E1) DM5T6US MT DME DM5T6US MA Metabolism DM5T6US RN Novel metabolic pathway of estrone and 17beta-estradiol catalyzed by cytochrome P-450. Drug Metab Dispos. 2000 Feb;28(2):110-2. DM5T6US RU https://www.ncbi.nlm.nih.gov/pubmed/?term=10640505 DM5T6US DI DM5T6US DM5T6US DN Estrone DM5T6US MI DE4LYSA DM5T6US MN Cytochrome P450 3A4 (CYP3A4) DM5T6US MT DME DM5T6US MA Metabolism DM5T6US RN Regioselective hydroxylation of steroid hormones by human cytochromes P450. Drug Metab Rev. 2015 May;47(2):89-110. DM5T6US RU https://www.ncbi.nlm.nih.gov/pubmed/?term=25678418 DM5T6US DI DM5T6US DM5T6US DN Estrone DM5T6US MI DEIBDNY DM5T6US MN Cytochrome P450 3A5 (CYP3A5) DM5T6US MT DME DM5T6US MA Metabolism DM5T6US RN 16Alpha-hydroxylation of estrone by human cytochrome P4503A4/5. Carcinogenesis. 1998 May;19(5):867-72. DM5T6US RU https://www.ncbi.nlm.nih.gov/pubmed/?term=9635876 DM5T6US DI DM5T6US DM5T6US DN Estrone DM5T6US MI DEBMFZ8 DM5T6US MN Estradiol 17-beta-dehydrogenase 2 (HSD17B2) DM5T6US MT DME DM5T6US MA Metabolism DM5T6US RN Steroid signalling in the ovarian surface epithelium. Trends Endocrinol Metab. 2005 Sep;16(7):327-33. DM5T6US RU https://www.ncbi.nlm.nih.gov/pubmed/?term=16054388 DM5T6US DI DM5T6US DM5T6US DN Estrone DM5T6US MI TTZAYWL DM5T6US MN Estrogen receptor (ESR) DM5T6US MT DTT DM5T6US MA Agonist DM5T6US RN Reprint of Are all estrogens the same Maturitas. 2008 Sep-Oct;61(1-2):195-201. DM5T6US RU https://pubmed.ncbi.nlm.nih.gov/19434891 DM5T6US DI DM5T6US DM5T6US DN Estrone DM5T6US MI DER0XCH DM5T6US MN Farnesol dehydrogenase (AKR1B15) DM5T6US MT DME DM5T6US MA Metabolism DM5T6US RN Aldo-keto Reductase 1B15 (AKR1B15): a mitochondrial human aldo-keto reductase with activity toward steroids and 3-keto-acyl-CoA conjugates. J Biol Chem. 2015 Mar 6;290(10):6531-45. DM5T6US RU https://www.ncbi.nlm.nih.gov/pubmed/?term=25577493 DM5T6US DI DM5T6US DM5T6US DN Estrone DM5T6US MI DE915QP DM5T6US MN Ketoacyl-CoA reductase (HSD17B12) DM5T6US MT DME DM5T6US MA Metabolism DM5T6US RN Characterization of type 12 17beta-hydroxysteroid dehydrogenase, an isoform of type 3 17beta-hydroxysteroid dehydrogenase responsible for estradiol formation in women. Mol Endocrinol. 2006 Feb;20(2):437-43. DM5T6US RU https://www.ncbi.nlm.nih.gov/pubmed/?term=16166196 DM5T6US DI DM5T6US DM5T6US DN Estrone DM5T6US MI DEDMWFX DM5T6US MN Keto-steroid reductase (HSD17B7) DM5T6US MT DME DM5T6US MA Metabolism DM5T6US RN Steroid signalling in the ovarian surface epithelium. Trends Endocrinol Metab. 2005 Sep;16(7):327-33. DM5T6US RU https://www.ncbi.nlm.nih.gov/pubmed/?term=16054388 DM5T6US DI DM5T6US DM5T6US DN Estrone DM5T6US MI DE2XQGW DM5T6US MN Lauric acid omega-hydroxylase (CYP4A11) DM5T6US MT DME DM5T6US MA Metabolism DM5T6US RN Characterization of the oxidative metabolites of 17beta-estradiol and estrone formed by 15 selectively expressed human cytochrome p450 isoforms. Endocrinology. 2003 Aug;144(8):3382-98. DM5T6US RU https://www.ncbi.nlm.nih.gov/pubmed/?term=12865317 DM5T6US DI DM5T6US DM5T6US DN Estrone DM5T6US MI DEJHG19 DM5T6US MN Peroxisomal multifunctional enzyme 2 (HSD17B4) DM5T6US MT DME DM5T6US MA Metabolism DM5T6US RN Steroid signalling in the ovarian surface epithelium. 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DMVBIZL RU http://www.ncbi.nlm.nih.gov/pubmed/12379217 DMVBIZL DI DMVBIZL DMVBIZL DN Estrone sulfate DMVBIZL MI DTI7UX6 DMVBIZL MN Breast cancer resistance protein (ABCG2) DMVBIZL MT DTP DMVBIZL MA Substrate DMVBIZL RN ABCG2 transports sulfated conjugates of steroids and xenobiotics. J Biol Chem. 2003 Jun 20;278(25):22644-9. DMVBIZL RU http://www.ncbi.nlm.nih.gov/pubmed/12682043 DMVBIZL DI DMVBIZL DMVBIZL DN Estrone sulfate DMVBIZL MI DTI7UX6 DMVBIZL MN Breast cancer resistance protein (ABCG2) DMVBIZL MT DTP DMVBIZL MA Substrate DMVBIZL RN Differential selectivity of efflux transporter inhibitors in Caco-2 and MDCK-MDR1 monolayers: a strategy to assess the interaction of a new chemical entity with P-gp, BCRP, and MRP2. J Pharm Sci. 2012 May;101(5):1888-97. DMVBIZL RU https://doi.org/10.1002/jps.23069 DMVBIZL DI DMVBIZL DMVBIZL DN Estrone sulfate DMVBIZL MI DTZGT0P DMVBIZL MN Multidrug and toxin extrusion protein 1 (SLC47A1) DMVBIZL MT DTP DMVBIZL MA Substrate DMVBIZL RN Substrate specificity of MATE1 and MATE2-K, human multidrug and toxin extrusions/H(+)-organic cation antiporters. Biochem Pharmacol. 2007 Jul 15;74(2):359-71. DMVBIZL RU http://www.ncbi.nlm.nih.gov/pubmed/17509534 DMVBIZL DI DMVBIZL DMVBIZL DN Estrone sulfate DMVBIZL MI DT3TX4H DMVBIZL MN Multidrug and toxin extrusion protein 2 (SLC47A2) DMVBIZL MT DTP DMVBIZL MA Substrate DMVBIZL RN Substrate specificity of MATE1 and MATE2-K, human multidrug and toxin extrusions/H(+)-organic cation antiporters. Biochem Pharmacol. 2007 Jul 15;74(2):359-71. DMVBIZL RU http://www.ncbi.nlm.nih.gov/pubmed/17509534 DMVBIZL DI DMVBIZL DMVBIZL DN Estrone sulfate DMVBIZL MI DTSYQGK DMVBIZL MN Multidrug resistance-associated protein 1 (ABCC1) DMVBIZL MT DTP DMVBIZL MA Substrate DMVBIZL RN Molecular cloning and pharmacological characterization of rat multidrug resistance protein 1 (mrp1). Drug Metab Dispos. 2003 Aug;31(8):1016-26. DMVBIZL RU http://www.ncbi.nlm.nih.gov/pubmed/12867490 DMVBIZL DI DMVBIZL DMVBIZL DN Estrone sulfate DMVBIZL MI DTFI42L DMVBIZL MN Multidrug resistance-associated protein 2 (ABCC2) DMVBIZL MT DTP DMVBIZL MA Substrate DMVBIZL RN Human hepatobiliary transport of organic anions analyzed by quadruple-transfected cells. Mol Pharmacol. 2005 Oct;68(4):1031-8. DMVBIZL RU http://www.ncbi.nlm.nih.gov/pubmed/16046661 DMVBIZL DI DMVBIZL DMVBIZL DN Estrone sulfate DMVBIZL MI DTVP67E DMVBIZL MN Organic anion transporter 3 (SLC22A8) DMVBIZL MT DTP DMVBIZL MA Substrate DMVBIZL RN Involvement of tyrosine kinase and PI3K in the regulation of OAT3-mediated estrone sulfate transport in isolated rabbit renal proximal tubules. Am J Physiol Renal Physiol. 2005 Nov;289(5):F1057-64. DMVBIZL RU http://www.ncbi.nlm.nih.gov/pubmed/15956776 DMVBIZL DI DMVBIZL DMVBIZL DN Estrone sulfate DMVBIZL MI DT06JWZ DMVBIZL MN Organic anion transporter 4 (SLC22A11) DMVBIZL MT DTP DMVBIZL MA Substrate DMVBIZL RN Inhibitory effects of angiotensin II receptor antagonists and leukotriene receptor antagonists on the transport of human organic anion transporter 4. J Pharm Pharmacol. 2006 Nov;58(11):1499-505. DMVBIZL RU http://www.ncbi.nlm.nih.gov/pubmed/17132213 DMVBIZL DI DMVBIZL DMVBIZL DN Estrone sulfate DMVBIZL MI DTT3IKQ DMVBIZL MN Organic anion transporter 6 (SLC22A20) DMVBIZL MT DTP DMVBIZL MA Substrate DMVBIZL RN Transport of estrone sulfate by the novel organic anion transporter Oat6 (Slc22a20). Am J Physiol Renal Physiol. 2006 Aug;291(2):F314-21. DMVBIZL RU http://www.ncbi.nlm.nih.gov/pubmed/16478971 DMVBIZL DI DMVBIZL DMVBIZL DN Estrone sulfate DMVBIZL MI DTE2B1D DMVBIZL MN Organic anion transporting polypeptide 1A2 (SLCO1A2) DMVBIZL MT DTP DMVBIZL MA Substrate DMVBIZL RN Determination of OATP-, NTCP- and OCT-mediated substrate uptake activities in individual and pooled batches of cryopreserved human hepatocytes. Eur J Pharm Sci. 2011 Jul 17;43(4):297-307. DMVBIZL RU http://www.ncbi.nlm.nih.gov/pubmed/21605667 DMVBIZL DI DMVBIZL DMVBIZL DN Estrone sulfate DMVBIZL MI DT3D8F0 DMVBIZL MN Organic anion transporting polypeptide 1B1 (SLCO1B1) DMVBIZL MT DTP DMVBIZL MA Substrate DMVBIZL RN Role of transmembrane domain 10 for the function of organic anion transporting polypeptide 1B1. Protein Sci. 2009 Nov;18(11):2298-306. DMVBIZL RU http://www.ncbi.nlm.nih.gov/pubmed/19760661 DMVBIZL DI DMVBIZL DMVBIZL DN Estrone sulfate DMVBIZL MI DT9C1TS DMVBIZL MN Organic anion transporting polypeptide 1B3 (SLCO1B3) DMVBIZL MT DTP DMVBIZL MA Substrate DMVBIZL RN Effect of pregnane X receptor ligands on transport mediated by human OATP1B1 and OATP1B3. Eur J Pharmacol. 2008 Apr 14;584(1):57-65. DMVBIZL RU http://www.ncbi.nlm.nih.gov/pubmed/18321482 DMVBIZL DI DMVBIZL DMVBIZL DN Estrone sulfate DMVBIZL MI DTPFTEQ DMVBIZL MN Organic anion transporting polypeptide 2B1 (SLCO2B1) DMVBIZL MT DTP DMVBIZL MA Substrate DMVBIZL RN Substrate-dependent drug-drug interactions between gemfibrozil, fluvastatin and other organic anion-transporting peptide (OATP) substrates on OATP1B1, OATP2B1, and OATP1B3. Drug Metab Dispos. 2007 Aug;35(8):1308-14. DMVBIZL RU http://www.ncbi.nlm.nih.gov/pubmed/17470528 DMVBIZL DI DMVBIZL DMVBIZL DN Estrone sulfate DMVBIZL MI DTVNRXW DMVBIZL MN Organic anion transporting polypeptide 3A1 (SLCO3A1) DMVBIZL MT DTP DMVBIZL MA Substrate DMVBIZL RN Molecular identification and characterization of novel members of the human organic anion transporter (OATP) family. Biochem Biophys Res Commun. 2000 Jun 24;273(1):251-60. DMVBIZL RU http://www.ncbi.nlm.nih.gov/pubmed/10873595 DMVBIZL DI DMVBIZL DMVBIZL DN Estrone sulfate DMVBIZL MI DT8H2IC DMVBIZL MN Organic anion transporting polypeptide 4A1 (SLCO4A1) DMVBIZL MT DTP DMVBIZL MA Substrate DMVBIZL RN Involvement of estrone-3-sulfate transporters in proliferation of hormone-dependent breast cancer cells. J Pharmacol Exp Ther. 2004 Dec;311(3):1032-7. DMVBIZL RU http://www.ncbi.nlm.nih.gov/pubmed/15328376 DMVBIZL DI DMVBIZL DMVBIZL DN Estrone sulfate DMVBIZL MI DTY0QMU DMVBIZL MN Organic anion transporting polypeptide 4C1 (SLCO4C1) DMVBIZL MT DTP DMVBIZL MA Substrate DMVBIZL RN Transport of estrone 3-sulfate mediated by organic anion transporter OATP4C1: estrone 3-sulfate binds to the different recognition site for digoxin in OATP4C1. Drug Metab Pharmacokinet. 2010;25(3):314-7. DMVBIZL RU http://www.ncbi.nlm.nih.gov/pubmed/20610891 DMVBIZL DI DMVBIZL DMVBIZL DN Estrone sulfate DMVBIZL MI DTMEQ32 DMVBIZL MN Organic solute transporter subunit alpha (SLC51A) DMVBIZL MT DTP DMVBIZL MA Substrate DMVBIZL RN Functional complementation between a novel mammalian polygenic transport complex and an evolutionarily ancient organic solute transporter, OSTalpha-OSTbeta. J Biol Chem. 2003 Jul 25;278(30):27473-82. DMVBIZL RU http://www.ncbi.nlm.nih.gov/pubmed/12719432 DMVBIZL DI DMVBIZL DMVBIZL DN Estrone sulfate DMVBIZL MI DT1V9AJ DMVBIZL MN Organic solute transporter subunit beta (SLC51B) DMVBIZL MT DTP DMVBIZL MA Substrate DMVBIZL RN Functional complementation between a novel mammalian polygenic transport complex and an evolutionarily ancient organic solute transporter, OSTalpha-OSTbeta. J Biol Chem. 2003 Jul 25;278(30):27473-82. DMVBIZL RU http://www.ncbi.nlm.nih.gov/pubmed/12719432 DMVBIZL DI DMVBIZL DMVBIZL DN Estrone sulfate DMVBIZL MI DT1V9AJ DMVBIZL MN Organic solute transporter subunit beta (SLC51B) DMVBIZL MT DTP DMVBIZL MA Substrate DMVBIZL RN Functional complementation between a novel mammalian polygenic transport complex and an evolutionarily ancient organic solute transporter, OSTalpha-OSTbeta. J Biol Chem. 2003 Jul 25;278(30):27473-82. DMVBIZL RU http://www.ncbi.nlm.nih.gov/pubmed/12719432 DMVBIZL DI DMVBIZL DMVBIZL DN Estrone sulfate DMVBIZL MI DTUGYRD DMVBIZL MN P-glycoprotein 1 (ABCB1) DMVBIZL MT DTP DMVBIZL MA Substrate DMVBIZL RN Identification of the hepatic efflux transporters of organic anions using double-transfected Madin-Darby canine kidney II cells expressing human organic anion-transporting polypeptide 1B1 (OATP1B1)/multidrug resistance-associated protein 2, OATP1B1/multidrug resistance 1, and OATP1B1/breast cancer resistance protein. J Pharmacol Exp Ther. 2005 Sep;314(3):1059-67. DMVBIZL RU https://doi.org/10.1124/jpet.105.085589 DMVBIZL DI DMVBIZL DMVBIZL DN Estrone sulfate DMVBIZL MI DT56EKP DMVBIZL MN Sodium/taurocholate cotransporting polypeptide (SLC10A1) DMVBIZL MT DTP DMVBIZL MA Substrate DMVBIZL RN Ethnicity-dependent polymorphism in Na+-taurocholate cotransporting polypeptide (SLC10A1) reveals a domain critical for bile acid substrate recognition. J Biol Chem. 2004 Feb 20;279(8):7213-22. DMVBIZL RU http://www.ncbi.nlm.nih.gov/pubmed/14660639 DMRMDWA DI DMRMDWA DMRMDWA DN Estropipate DMRMDWA MI DE4LYSA DMRMDWA MN Cytochrome P450 3A4 (CYP3A4) DMRMDWA MT DME DMRMDWA MA Metabolism DMRMDWA RN Estrogen regulation of the cytochrome P450 3A subfamily in humans. J Pharmacol Exp Ther. 2004 Nov;311(2):728-35. DMRMDWA RU https://www.ncbi.nlm.nih.gov/pubmed/?term=15282264 DMRMDWA DI DMRMDWA DMRMDWA DN Estropipate DMRMDWA MI TTZAYWL DMRMDWA MN Estrogen receptor (ESR) DMRMDWA MT DTT DMRMDWA MA Modulator DMRMDWA RN US patent application no. 5,004,651, Stabilizing system for solid dosage forms. DMRMDWA RU http://www.google.com/patents/US5004651 DM8RZ9H DI DM8RZ9H DM8RZ9H DN Eszopiclone DM8RZ9H MI DES5XRU DM8RZ9H MN Cytochrome P450 2C8 (CYP2C8) DM8RZ9H MT DME DM8RZ9H MA Metabolism DM8RZ9H RN Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. DM8RZ9H RU https://www.ncbi.nlm.nih.gov/pubmed/?term=19515014 DM8RZ9H DI DM8RZ9H DM8RZ9H DN Eszopiclone DM8RZ9H MI DEVDYN7 DM8RZ9H MN Cytochrome P450 2E1 (CYP2E1) DM8RZ9H MT DME DM8RZ9H MA Metabolism DM8RZ9H RN Eszopiclone, a nonbenzodiazepine sedative-hypnotic agent for the treatment of transient and chronic insomnia. Clin Ther. 2006 Apr;28(4):491-516. DM8RZ9H RU https://www.ncbi.nlm.nih.gov/pubmed/?term=16750462 DM8RZ9H DI DM8RZ9H DM8RZ9H DN Eszopiclone DM8RZ9H MI DE4LYSA DM8RZ9H MN Cytochrome P450 3A4 (CYP3A4) DM8RZ9H MT DME DM8RZ9H MA Metabolism DM8RZ9H RN Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. DM8RZ9H RU https://www.ncbi.nlm.nih.gov/pubmed/?term=19515014 DM8RZ9H DI DM8RZ9H DM8RZ9H DN Eszopiclone DM8RZ9H MI TTPTXIN DM8RZ9H MN Translocator protein (TSPO) DM8RZ9H MT DTT DM8RZ9H MA Agonist DM8RZ9H RN New hypnotics: perspectives from sleep physiology. Vertex. 2007 Jul-Aug;18(74):294-9. DM8RZ9H RU https://pubmed.ncbi.nlm.nih.gov/18265473 DMCV109 DI DMCV109 DMCV109 DN Etanercept DMCV109 MI TTF8CQI DMCV109 MN Tumor necrosis factor (TNF) DMCV109 MT DTT DMCV109 MA Modulator DMCV109 RN The potential of biologics for the treatment of asthma. Nat Rev Drug Discov. 2012 Dec;11(12):958-72. DMCV109 RU https://www.ncbi.nlm.nih.gov/pubmed/23197041 DMHP9BL DI DMHP9BL DMHP9BL DN Etelcalcetide DMHP9BL MI TTBUYHA DMHP9BL MN Extracellular calcium-sensing receptor (CASR) DMHP9BL MT DTT DMHP9BL MA Modulator DMHP9BL RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. DMHP9BL RU https://www.fda.gov/ DM2QBHP DI DM2QBHP DM2QBHP DN Eteplirsen DM2QBHP MI TTWLFXU DM2QBHP MN Dystrophin messenger RNA (DMD mRNA) DM2QBHP MT DTT DM2QBHP MA Modulator DM2QBHP RN 2016 FDA drug approvals. Nat Rev Drug Discov. 2017 Feb 2;16(2):73-76. DM2QBHP RU https://www.ncbi.nlm.nih.gov/pubmed/28148938 DM5M4NT DI DM5M4NT DM5M4NT DN Ethacrynate sodium DM5M4NT MI TTS087L DM5M4NT MN Solute carrier family 12 member 1 (SLC12A1) DM5M4NT MT DTT DM5M4NT MA Modulator DM5M4NT RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. DM5M4NT RU https://www.fda.gov/ DM60QMR DI DM60QMR DM60QMR DN Ethacrynic acid DM60QMR MI DE6OQ3W DM60QMR MN Cytochrome P450 1A1 (CYP1A1) DM60QMR MT DME DM60QMR MA Metabolism DM60QMR RN Xenobiotic metabolizing and antioxidant enzymes in normal and neoplastic human breast tissue. Eur J Drug Metab Pharmacokinet. 1998 Oct-Dec;23(4):497-500. DM60QMR RU https://www.ncbi.nlm.nih.gov/pubmed/?term=10323333 DM60QMR DI DM60QMR DM60QMR DN Ethacrynic acid DM60QMR MI DE4ZHS1 DM60QMR MN Glutathione S-transferase alpha-1 (GSTA1) DM60QMR MT DME DM60QMR MA Metabolism DM60QMR RN Purification and biochemical properties of glutathione S-transferase from Lactuca sativa. J Biochem Mol Biol. 2005 Mar 31;38(2):232-7. DM60QMR RU https://www.ncbi.nlm.nih.gov/pubmed/?term=15826502 DM60QMR DI DM60QMR DM60QMR DN Ethacrynic acid DM60QMR MI DTSYQGK DM60QMR MN Multidrug resistance-associated protein 1 (ABCC1) DM60QMR MT DTP DM60QMR MA Substrate DM60QMR RN Inhibition of the multidrug resistance protein 1 (MRP1) by peptidomimetic glutathione-conjugate analogs. Mol Pharmacol. 2002 Nov;62(5):1160-6. DM60QMR RU http://www.ncbi.nlm.nih.gov/pubmed/12391280 DM60QMR DI DM60QMR DM60QMR DN Ethacrynic acid DM60QMR MI TTS087L DM60QMR MN Solute carrier family 12 member 1 (SLC12A1) DM60QMR MT DTT DM60QMR MA Blocker DM60QMR RN Na-K-Cl cotransport regulates intracellular volume and monolayer permeability of trabecular meshwork cells. Am J Physiol. 1995 Apr;268(4 Pt 1):C1067-74. DM60QMR RU https://pubmed.ncbi.nlm.nih.gov/7733229 DMR87LC DI DMR87LC DMR87LC DN Ethambutol DMR87LC MI TT1Q8GP DMR87LC MN Mycobacterium Arabinosyltransferase C (MycB embC) DMR87LC MT DTT DMR87LC MA Inhibitor DMR87LC RN The arabinosyltransferase EmbC is inhibited by ethambutol in Mycobacterium tuberculosis. Antimicrob Agents Chemother. 2009 Oct;53(10):4138-46. DMR87LC RU https://pubmed.ncbi.nlm.nih.gov/19596878 DMDRQZU DI DMDRQZU DMDRQZU DN Ethanol DMDRQZU MI DEG8NJD DMDRQZU MN Alcohol dehydrogenase (ADH) DMDRQZU MT DME DMDRQZU MA Metabolism DMDRQZU RN Functional profiles of coronal and dentin caries in children. J Oral Microbiol. 2018 Jul 16;10(1):1495976. DMDRQZU RU https://pubmed.ncbi.nlm.nih.gov/30034639 DMDRQZU DI DMDRQZU DMDRQZU DN Ethanol DMDRQZU MI DEE5M8O DMDRQZU MN Alcohol dehydrogenase class-I alpha (ADH1A) DMDRQZU MT DME DMDRQZU MA Metabolism DMDRQZU RN Natural alcohol exposure: is ethanol the main substrate for alcohol dehydrogenases in animals? Chem Biol Interact. 2011 May 30;191(1-3):14-25. DMDRQZU RU https://www.ncbi.nlm.nih.gov/pubmed/?term=21329681 DMDRQZU DI DMDRQZU DMDRQZU DN Ethanol DMDRQZU MI DEEN9RD DMDRQZU MN Alcohol dehydrogenase class-I beta (ADH1B) DMDRQZU MT DME DMDRQZU MA Metabolism DMDRQZU RN Natural alcohol exposure: is ethanol the main substrate for alcohol dehydrogenases in animals? Chem Biol Interact. 2011 May 30;191(1-3):14-25. DMDRQZU RU https://www.ncbi.nlm.nih.gov/pubmed/?term=21329681 DMDRQZU DI DMDRQZU DMDRQZU DN Ethanol DMDRQZU MI DEM1HNL DMDRQZU MN Alcohol dehydrogenase class-I gamma (ADH1C) DMDRQZU MT DME DMDRQZU MA Metabolism DMDRQZU RN Natural alcohol exposure: is ethanol the main substrate for alcohol dehydrogenases in animals? Chem Biol Interact. 2011 May 30;191(1-3):14-25. DMDRQZU RU https://www.ncbi.nlm.nih.gov/pubmed/?term=21329681 DMDRQZU DI DMDRQZU DMDRQZU DN Ethanol DMDRQZU MI DEOCWU3 DMDRQZU MN Alcohol dehydrogenase class-II (ADH4) DMDRQZU MT DME DMDRQZU MA Metabolism DMDRQZU RN Oxidation of alcohols and reduction of aldehydes derived from methyl- and dimethylpyrenes by cDNA-expressed human alcohol dehydrogenases. Toxicology. 2008 Mar 12;245(1-2):65-75. DMDRQZU RU https://www.ncbi.nlm.nih.gov/pubmed/?term=18242813 DMDRQZU DI DMDRQZU DMDRQZU DN Ethanol DMDRQZU MI DEIOH6A DMDRQZU MN Alcohol dehydrogenase class-III (ADH5) DMDRQZU MT DME DMDRQZU MA Metabolism DMDRQZU RN Functional assessment of human alcohol dehydrogenase family in ethanol metabolism: significance of first-pass metabolism. Alcohol Clin Exp Res. 2006 Jul;30(7):1132-42. DMDRQZU RU https://www.ncbi.nlm.nih.gov/pubmed/?term=16792560 DMDRQZU DI DMDRQZU DMDRQZU DN Ethanol DMDRQZU MI DE017IC DMDRQZU MN Alcohol dehydrogenase class-V (ADH6) DMDRQZU MT DME DMDRQZU MA Metabolism DMDRQZU RN Functional assessment of human alcohol dehydrogenase family in ethanol metabolism: significance of first-pass metabolism. Alcohol Clin Exp Res. 2006 Jul;30(7):1132-42. DMDRQZU RU https://www.ncbi.nlm.nih.gov/pubmed/?term=16792560 DMDRQZU DI DMDRQZU DMDRQZU DN Ethanol DMDRQZU MI DED2FW3 DMDRQZU MN Aldo-keto reductase 1A1 (AKR1A1) DMDRQZU MT DME DMDRQZU MA Metabolism DMDRQZU RN Functional assessment of human alcohol dehydrogenase family in ethanol metabolism: significance of first-pass metabolism. Alcohol Clin Exp Res. 2006 Jul;30(7):1132-42. DMDRQZU RU https://www.ncbi.nlm.nih.gov/pubmed/?term=16792560 DMDRQZU DI DMDRQZU DMDRQZU DN Ethanol DMDRQZU MI DEJGDUW DMDRQZU MN Cytochrome P450 1A2 (CYP1A2) DMDRQZU MT DME DMDRQZU MA Metabolism DMDRQZU RN Summary of information on human CYP enzymes: human P450 metabolism data. Drug Metab Rev. 2002 Feb-May;34(1-2):83-448. DMDRQZU RU https://www.ncbi.nlm.nih.gov/pubmed/?term=11996015 DMDRQZU DI DMDRQZU DMDRQZU DN Ethanol DMDRQZU MI DEVDYN7 DMDRQZU MN Cytochrome P450 2E1 (CYP2E1) DMDRQZU MT DME DMDRQZU MA Metabolism DMDRQZU RN CYP2E1 and clinical features in alcoholics. Neuropsychobiology. 2003;47(2):86-9. DMDRQZU RU https://www.ncbi.nlm.nih.gov/pubmed/?term=12707490 DMDRQZU DI DMDRQZU DMDRQZU DN Ethanol DMDRQZU MI DE4LYSA DMDRQZU MN Cytochrome P450 3A4 (CYP3A4) DMDRQZU MT DME DMDRQZU MA Metabolism DMDRQZU RN Summary of information on human CYP enzymes: human P450 metabolism data. Drug Metab Rev. 2002 Feb-May;34(1-2):83-448. DMDRQZU RU https://www.ncbi.nlm.nih.gov/pubmed/?term=11996015 DMDRQZU DI DMDRQZU DMDRQZU DN Ethanol DMDRQZU MI TT1MPAY DMDRQZU MN GABA(A) receptor alpha-1 (GABRA1) DMDRQZU MT DTT DMDRQZU MA Antagonist DMDRQZU RN DrugBank: a knowledgebase for drugs, drug actions and drug targets. Nucleic Acids Res. 2008 Jan;36(Database issue):D901-6. DMDRQZU RU https://pubmed.ncbi.nlm.nih.gov/18048412 DMDRQZU DI DMDRQZU DMDRQZU DN Ethanol DMDRQZU MI DEZMAHX DMDRQZU MN Gastric alcohol dehydrogenase (ADH7) DMDRQZU MT DME DMDRQZU MA Metabolism DMDRQZU RN Functional assessment of human alcohol dehydrogenase family in ethanol metabolism: significance of first-pass metabolism. Alcohol Clin Exp Res. 2006 Jul;30(7):1132-42. DMDRQZU RU https://www.ncbi.nlm.nih.gov/pubmed/?term=16792560 DMDRQZU DI DMDRQZU DMDRQZU DN Ethanol DMDRQZU MI DEYGVN4 DMDRQZU MN UDP-glucuronosyltransferase 1A1 (UGT1A1) DMDRQZU MT DME DMDRQZU MA Metabolism DMDRQZU RN Identification and preliminary characterization of UDP-glucuronosyltransferases catalyzing formation of ethyl glucuronide. Anal Bioanal Chem. 2014 Apr;406(9-10):2325-32. DMDRQZU RU https://www.ncbi.nlm.nih.gov/pubmed/?term=24553666 DM3B654 DI DM3B654 DM3B654 DN Ethanolamine oleate DM3B654 MI DEVDYN7 DM3B654 MN Cytochrome P450 2E1 (CYP2E1) DM3B654 MT DME DM3B654 MA Metabolism DM3B654 RN CYP2E1--biochemical and toxicological aspects and role in alcohol-induced liver injury. Mt Sinai J Med. 2006 Jul;73(4):657-72. DM3B654 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=16878272 DM53IP1 DI DM53IP1 DM53IP1 DN Ethchlorvynol DM53IP1 MI DE4LYSA DM53IP1 MN Cytochrome P450 3A4 (CYP3A4) DM53IP1 MT DME DM53IP1 MA Metabolism DM53IP1 RN Alkylation of the prosthetic heme in cytochrome P-450 during oxidative metabolism of the sedative-hypnotic ethchlorvynol. J Med Chem. 1982 Oct;25(10):1174-9. DM53IP1 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=7143353 DM53IP1 DI DM53IP1 DM53IP1 DN Ethchlorvynol DM53IP1 MI TT1MPAY DM53IP1 MN GABA(A) receptor alpha-1 (GABRA1) DM53IP1 MT DTT DM53IP1 MA Antagonist DM53IP1 RN DrugBank: a knowledgebase for drugs, drug actions and drug targets. Nucleic Acids Res. 2008 Jan;36(Database issue):D901-6. DM53IP1 RU https://pubmed.ncbi.nlm.nih.gov/18048412 DM53IP1 DI DM53IP1 DM53IP1 DN Ethchlorvynol DM53IP1 MI TTZA1NY DM53IP1 MN GABA(A) receptor beta-2 (GABRB2) DM53IP1 MT DTT DM53IP1 MA Antagonist DM53IP1 RN DrugBank: a knowledgebase for drugs, drug actions and drug targets. Nucleic Acids Res. 2008 Jan;36(Database issue):D901-6. DM53IP1 RU https://pubmed.ncbi.nlm.nih.gov/18048412 DMK57GB DI DMK57GB DMK57GB DN Ethinamate DMK57GB MI TTANPDJ DMK57GB MN Carbonic anhydrase II (CA-II) DMK57GB MT DTT DMK57GB MA Inhibitor DMK57GB RN Inhibition of carbonic anhydrases I and II by N-unsubstituted carbamate esters. J Biol Chem. 1992 Dec 15;267(35):25044-50. DMK57GB RU https://pubmed.ncbi.nlm.nih.gov/1460006 DMODJ40 DI DMODJ40 DMODJ40 DN Ethinyl estradiol DMODJ40 MI DE6OQ3W DMODJ40 MN Cytochrome P450 1A1 (CYP1A1) DMODJ40 MT DME DMODJ40 MA Metabolism DMODJ40 RN The involvement of CYP3A4 and CYP2C9 in the metabolism of 17 alpha-ethinylestradiol. Drug Metab Dispos. 2004 Nov;32(11):1209-12. DMODJ40 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=15304426 DMODJ40 DI DMODJ40 DMODJ40 DN Ethinyl estradiol DMODJ40 MI DES5XRU DMODJ40 MN Cytochrome P450 2C8 (CYP2C8) DMODJ40 MT DME DMODJ40 MA Metabolism DMODJ40 RN Examination of 209 drugs for inhibition of cytochrome P450 2C8. J Clin Pharmacol. 2005 Jan;45(1):68-78. DMODJ40 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=15601807 DMODJ40 DI DMODJ40 DMODJ40 DN Ethinyl estradiol DMODJ40 MI DE5IED8 DMODJ40 MN Cytochrome P450 2C9 (CYP2C9) DMODJ40 MT DME DMODJ40 MA Metabolism DMODJ40 RN The involvement of CYP3A4 and CYP2C9 in the metabolism of 17 alpha-ethinylestradiol. Drug Metab Dispos. 2004 Nov;32(11):1209-12. DMODJ40 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=15304426 DMODJ40 DI DMODJ40 DMODJ40 DN Ethinyl estradiol DMODJ40 MI DE4LYSA DMODJ40 MN Cytochrome P450 3A4 (CYP3A4) DMODJ40 MT DME DMODJ40 MA Metabolism DMODJ40 RN Rifampicin, a keystone inducer of drug metabolism: from Herbert Remmer's pioneering ideas to modern concepts. Drug Metab Rev. 2004 Oct;36(3-4):497-509. DMODJ40 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=15554232 DMODJ40 DI DMODJ40 DMODJ40 DN Ethinyl estradiol DMODJ40 MI TTZAYWL DMODJ40 MN Estrogen receptor (ESR) DMODJ40 MT DTT DMODJ40 MA Agonist DMODJ40 RN 17alpha-Ethinylestradiol hinders nucleotide excision repair in zebrafish liver cells. Aquat Toxicol. 2009 Dec 13;95(4):273-8. DMODJ40 RU https://pubmed.ncbi.nlm.nih.gov/19237207 DMODJ40 DI DMODJ40 DMODJ40 DN Ethinyl estradiol DMODJ40 MI DEGTFWK DMODJ40 MN Mephenytoin 4-hydroxylase (CYP2C19) DMODJ40 MT DME DMODJ40 MA Metabolism DMODJ40 RN The effect of ethinyloestradiol and levonorgestrel on the CYP2C19-mediated metabolism of omeprazole in healthy female subjects. Br J Clin Pharmacol. 2003 Aug;56(2):232-7. DMODJ40 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=12895199 DMODJ40 DI DMODJ40 DMODJ40 DN Ethinyl estradiol DMODJ40 MI DTUGYRD DMODJ40 MN P-glycoprotein 1 (ABCB1) DMODJ40 MT DTP DMODJ40 MA Substrate DMODJ40 RN P-glycoprotein (P-gp/MDR1)-mediated efflux of sex-steroid hormones and modulation of P-gp expression in vitro. Pharm Res. 2004 Jul;21(7):1284-93. DMODJ40 RU http://www.ncbi.nlm.nih.gov/pubmed/15290871 DMODJ40 DI DMODJ40 DMODJ40 DN Ethinyl estradiol DMODJ40 MI DEYGVN4 DMODJ40 MN UDP-glucuronosyltransferase 1A1 (UGT1A1) DMODJ40 MT DME DMODJ40 MA Metabolism DMODJ40 RN Drug-drug interactions for UDP-glucuronosyltransferase substrates: a pharmacokinetic explanation for typically observed low exposure (AUCi/AUC) ratios. Drug Metab Dispos. 2004 Nov;32(11):1201-8. DMODJ40 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=15304429 DM8K3EI DI DM8K3EI DM8K3EI DN Ethionamide DM8K3EI MI TTVTX4N DM8K3EI MN Bacterial Fatty acid synthetase I (Bact inhA) DM8K3EI MT DTT DM8K3EI MA Inhibitor DM8K3EI RN Mechanism of thioamide drug action against tuberculosis and leprosy. J Exp Med. 2007 Jan 22;204(1):73-8. DM8K3EI RU https://pubmed.ncbi.nlm.nih.gov/17227913 DM8K3EI DI DM8K3EI DM8K3EI DN Ethionamide DM8K3EI MI DEIASEZ DM8K3EI MN Dimethylaniline oxidase 2 (FMO2) DM8K3EI MT DME DM8K3EI MA Metabolism DM8K3EI RN Drug metabolism by flavin-containing monooxygenases of human and mouse. Expert Opin Drug Metab Toxicol. 2017 Feb;13(2):167-181. DM8K3EI RU https://pubmed.ncbi.nlm.nih.gov/27678284 DM8K3EI DI DM8K3EI DM8K3EI DN Ethionamide DM8K3EI MI DEP76YL DM8K3EI MN Dimethylaniline oxidase 3 (FMO3) DM8K3EI MT DME DM8K3EI MA Metabolism DM8K3EI RN Physiologically based pharmacokinetic modeling approach to predict drug-drug interactions with ethionamide involving impact of genetic polymorphism on FMO3. J Clin Pharmacol. 2019 Jun;59(6):880-889. DM8K3EI RU https://www.ncbi.nlm.nih.gov/pubmed/?term=30690726 DM0N3L7 DI DM0N3L7 DM0N3L7 DN Ethopropazine DM0N3L7 MI TTTIBOJ DM0N3L7 MN Histamine H1 receptor (H1R) DM0N3L7 MT DTT DM0N3L7 MA Modulator DM0N3L7 RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. DM0N3L7 RU https://www.fda.gov/ DMDZ9LT DI DMDZ9LT DMDZ9LT DN Ethosuximide DMDZ9LT MI DEVDYN7 DMDZ9LT MN Cytochrome P450 2E1 (CYP2E1) DMDZ9LT MT DME DMDZ9LT MA Metabolism DMDZ9LT RN Characterization of the cytochrome P450 enzymes involved in the in vitro metabolism of ethosuximide by human hepatic microsomal enzymes. Xenobiotica. 2003 Mar;33(3):265-76. DMDZ9LT RU https://www.ncbi.nlm.nih.gov/pubmed/?term=12637244 DMDZ9LT DI DMDZ9LT DMDZ9LT DN Ethosuximide DMDZ9LT MI DE4LYSA DMDZ9LT MN Cytochrome P450 3A4 (CYP3A4) DMDZ9LT MT DME DMDZ9LT MA Metabolism DMDZ9LT RN Characterization of the cytochrome P450 enzymes involved in the in vitro metabolism of ethosuximide by human hepatic microsomal enzymes. Xenobiotica. 2003 Mar;33(3):265-76. DMDZ9LT RU https://www.ncbi.nlm.nih.gov/pubmed/?term=12637244 DMDZ9LT DI DMDZ9LT DMDZ9LT DN Ethosuximide DMDZ9LT MI DEO1IE3 DMDZ9LT MN Cytochrome P450 3A43 (CYP3A43) DMDZ9LT MT DME DMDZ9LT MA Metabolism DMDZ9LT RN Characterization of the cytochrome P450 enzymes involved in the in vitro metabolism of ethosuximide by human hepatic microsomal enzymes. Xenobiotica. 2003 Mar;33(3):265-76. DMDZ9LT RU https://www.ncbi.nlm.nih.gov/pubmed/?term=12637244 DMDZ9LT DI DMDZ9LT DMDZ9LT DN Ethosuximide DMDZ9LT MI DEIBDNY DMDZ9LT MN Cytochrome P450 3A5 (CYP3A5) DMDZ9LT MT DME DMDZ9LT MA Metabolism DMDZ9LT RN Characterization of the cytochrome P450 enzymes involved in the in vitro metabolism of ethosuximide by human hepatic microsomal enzymes. Xenobiotica. 2003 Mar;33(3):265-76. DMDZ9LT RU https://www.ncbi.nlm.nih.gov/pubmed/?term=12637244 DMDZ9LT DI DMDZ9LT DMDZ9LT DN Ethosuximide DMDZ9LT MI DERD86B DMDZ9LT MN Cytochrome P450 3A7 (CYP3A7) DMDZ9LT MT DME DMDZ9LT MA Metabolism DMDZ9LT RN Characterization of the cytochrome P450 enzymes involved in the in vitro metabolism of ethosuximide by human hepatic microsomal enzymes. Xenobiotica. 2003 Mar;33(3):265-76. DMDZ9LT RU https://www.ncbi.nlm.nih.gov/pubmed/?term=12637244 DMDZ9LT DI DMDZ9LT DMDZ9LT DN Ethosuximide DMDZ9LT MI TT729IR DMDZ9LT MN Voltage-gated calcium channel alpha Cav3.1 (CACNA1G) DMDZ9LT MT DTT DMDZ9LT MA Blocker DMDZ9LT RN Maladaptive homeostatic plasticity in a rodent model of central pain syndrome: thalamic hyperexcitability after spinothalamic tract lesions. J Neurosci. 2008 Nov 12;28(46):11959-69. DMDZ9LT RU https://pubmed.ncbi.nlm.nih.gov/19005061 DMXWOCP DI DMXWOCP DMXWOCP DN Ethotoin DMXWOCP MI TTZOVE0 DMXWOCP MN Voltage-gated sodium channel alpha Nav1.5 (SCN5A) DMXWOCP MT DTT DMXWOCP MA Blocker DMXWOCP RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMXWOCP RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMVO4ED DI DMVO4ED DMVO4ED DN Ethoxzolamide DMVO4ED MI TTHQPL7 DMVO4ED MN Carbonic anhydrase I (CA-I) DMVO4ED MT DTT DMVO4ED MA Modulator DMVO4ED RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. DMVO4ED RU https://www.fda.gov/ DMVO4ED DI DMVO4ED DMVO4ED DN Ethoxzolamide DMVO4ED MI TTANPDJ DMVO4ED MN Carbonic anhydrase II (CA-II) DMVO4ED MT DTT DMVO4ED MA Inhibitor DMVO4ED RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DMVO4ED RU https://pubmed.ncbi.nlm.nih.gov/10592235 DM20VMW DI DM20VMW DM20VMW DN Ethylestrenol DM20VMW MI TTS64P2 DM20VMW MN Androgen receptor (AR) DM20VMW MT DTT DM20VMW MA Modulator DM20VMW RN Relative binding affinity of anabolic-androgenic steroids: comparison of the binding to the androgen receptors in skeletal muscle and in prostate, ... Endocrinology. 1984 Jun;114(6):2100-6. DM20VMW RU https://www.ncbi.nlm.nih.gov/pubmed/6539197 DMZM84R DI DMZM84R DMZM84R DN Ethynodiol diacetate DMZM84R MI DE4LYSA DMZM84R MN Cytochrome P450 3A4 (CYP3A4) DMZM84R MT DME DMZM84R MA Metabolism DMZM84R RN News and information in drug research: Ethynodiol diacetate. DMZM84R RU http://genelabs.com/drugsdb/details/ethynodiol-diacetate/ DMZM84R DI DMZM84R DMZM84R DN Ethynodiol diacetate DMZM84R MI TTUV8G9 DMZM84R MN Progesterone receptor (PGR) DMZM84R MT DTT DMZM84R MA Binder DMZM84R RN Contribution of functional groups of 19-nor-progestogens to binding to progesterone and estradiol-17beta receptors in rabbit uterus. Endocrinology. 1977 Jun;100(6):1579-84. DMZM84R RU https://pubmed.ncbi.nlm.nih.gov/858280 DMBIYNH DI DMBIYNH DMBIYNH DN ETI-204 DMBIYNH MI TTRLPUB DMBIYNH MN Bacillus anthracis Protective antigen (Anthrax PA) DMBIYNH MT DTT DMBIYNH RN Efficacy of ETI-204 monoclonal antibody as an adjunct therapy in a New Zealand white rabbit partial survival model for inhalational anthrax. Antimicrob Agents Chemother. 2015 Apr;59(4):2206-14. DMBIYNH RU https://pubmed.ncbi.nlm.nih.gov/25645849 DMAWJIN DI DMAWJIN DMAWJIN DN Etidronate Disodium DMAWJIN MI TT8X5NO DMAWJIN MN Calcium (Ca) DMAWJIN MT DTT DMAWJIN MA Modulator DMAWJIN RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. DMAWJIN RU https://www.fda.gov/ DMAWJIN DI DMAWJIN DMAWJIN DN Etidronate Disodium DMAWJIN MI TTUDR0C DMAWJIN MN Iron (Fe) DMAWJIN MT DTT DMAWJIN MA Modulator DMAWJIN RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. DMAWJIN RU https://www.fda.gov/ DM1XHYJ DI DM1XHYJ DM1XHYJ DN Etidronic acid DM1XHYJ MI TTCWXFA DM1XHYJ MN Protein-tyrosine phosphatase sigma (R-PTP-sigma) DM1XHYJ MT DTT DM1XHYJ MA Inhibitor DM1XHYJ RN Human protein tyrosine phosphatase-sigma: alternative splicing and inhibition by bisphosphonates. J Bone Miner Res. 1996 Apr;11(4):535-43. DM1XHYJ RU https://pubmed.ncbi.nlm.nih.gov/8992885 DM6WJO9 DI DM6WJO9 DM6WJO9 DN Etodolac DM6WJO9 MI DE5IED8 DM6WJO9 MN Cytochrome P450 2C9 (CYP2C9) DM6WJO9 MT DME DM6WJO9 MA Metabolism DM6WJO9 RN Stereoselective glucuronidation and hydroxylation of etodolac by UGT1A9 and CYP2C9 in man. Xenobiotica. 2004 May;34(5):449-61. DM6WJO9 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=15370961 DM6WJO9 DI DM6WJO9 DM6WJO9 DN Etodolac DM6WJO9 MI TTVKILB DM6WJO9 MN Prostaglandin G/H synthase 2 (COX-2) DM6WJO9 MT DTT DM6WJO9 MA Inhibitor DM6WJO9 RN Membranous nephropathy associated with the relatively selective cyclooxygenase-2 inhibitor, etodolac, in a patient with early rheumatoid arthritis. Intern Med. 2007;46(13):1055-8. DM6WJO9 RU https://pubmed.ncbi.nlm.nih.gov/17603251 DM6WJO9 DI DM6WJO9 DM6WJO9 DN Etodolac DM6WJO9 MI DEYGVN4 DM6WJO9 MN UDP-glucuronosyltransferase 1A1 (UGT1A1) DM6WJO9 MT DME DM6WJO9 MA Metabolism DM6WJO9 RN Stereoselective glucuronidation and hydroxylation of etodolac by UGT1A9 and CYP2C9 in man. Xenobiotica. 2004 May;34(5):449-61. DM6WJO9 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=15370961 DM6WJO9 DI DM6WJO9 DM6WJO9 DN Etodolac DM6WJO9 MI DEL5N6Y DM6WJO9 MN UDP-glucuronosyltransferase 1A10 (UGT1A10) DM6WJO9 MT DME DM6WJO9 MA Metabolism DM6WJO9 RN Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. DM6WJO9 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=19515014 DM6WJO9 DI DM6WJO9 DM6WJO9 DN Etodolac DM6WJO9 MI DEF2WXN DM6WJO9 MN UDP-glucuronosyltransferase 1A3 (UGT1A3) DM6WJO9 MT DME DM6WJO9 MA Metabolism DM6WJO9 RN Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. DM6WJO9 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=19515014 DM6WJO9 DI DM6WJO9 DM6WJO9 DN Etodolac DM6WJO9 MI DE85D2P DM6WJO9 MN UDP-glucuronosyltransferase 1A9 (UGT1A9) DM6WJO9 MT DME DM6WJO9 MA Metabolism DM6WJO9 RN Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. DM6WJO9 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=19515014 DM6WJO9 DI DM6WJO9 DM6WJO9 DN Etodolac DM6WJO9 MI DEB3CV1 DM6WJO9 MN UDP-glucuronosyltransferase 2B7 (UGT2B7) DM6WJO9 MT DME DM6WJO9 MA Metabolism DM6WJO9 RN Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. DM6WJO9 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=19515014 DMZI3WO DI DMZI3WO DMZI3WO DN Etomidate DMZI3WO MI TTEX6LM DMZI3WO MN GABA(A) receptor gamma-3 (GABRG3) DMZI3WO MT DTT DMZI3WO MA Modulator DMZI3WO RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. DMZI3WO RU https://www.fda.gov/ DMKA8J4 DI DMKA8J4 DMKA8J4 DN Etonogestrel DMKA8J4 MI DE4LYSA DMKA8J4 MN Cytochrome P450 3A4 (CYP3A4) DMKA8J4 MT DME DMKA8J4 MA Metabolism DMKA8J4 RN The role of CYP2C and CYP3A in the disposition of 3-keto-desogestrel after administration of desogestrel. Br J Clin Pharmacol. 2005 Jul;60(1):69-75. DMKA8J4 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=15963096 DMKA8J4 DI DMKA8J4 DMKA8J4 DN Etonogestrel DMKA8J4 MI TTUV8G9 DMKA8J4 MN Progesterone receptor (PGR) DMKA8J4 MT DTT DMKA8J4 MA Binder DMKA8J4 RN Pharmacological profile of progestins. Maturitas. 2008 Sep-Oct;61(1-2):151-7. DMKA8J4 RU https://pubmed.ncbi.nlm.nih.gov/19434887 DMNH3PG DI DMNH3PG DMNH3PG DN Etoposide DMNH3PG MI DTI7UX6 DMNH3PG MN Breast cancer resistance protein (ABCG2) DMNH3PG MT DTP DMNH3PG MA Substrate DMNH3PG RN Characterization of 3-methoxy flavones for their interaction with ABCG2 as suggested by ATPase activity. Biochim Biophys Acta. 2014 Nov;1838(11):2929-38. DMNH3PG RU http://www.ncbi.nlm.nih.gov/pubmed/25128152 DMNH3PG DI DMNH3PG DMNH3PG DN Etoposide DMNH3PG MI DEJGDUW DMNH3PG MN Cytochrome P450 1A2 (CYP1A2) DMNH3PG MT DME DMNH3PG MA Metabolism DMNH3PG RN Effects of morin on the pharmacokinetics of etoposide in rats. Biopharm Drug Dispos. 2007 Apr;28(3):151-6. DMNH3PG RU https://www.ncbi.nlm.nih.gov/pubmed/?term=17315145 DMNH3PG DI DMNH3PG DMNH3PG DN Etoposide DMNH3PG MI DEVDYN7 DMNH3PG MN Cytochrome P450 2E1 (CYP2E1) DMNH3PG MT DME DMNH3PG MA Metabolism DMNH3PG RN A study on the metabolism of etoposide and possible interactions with antitumor or supporting agents by human liver microsomes. J Pharmacol Exp Ther. 1998 Sep;286(3):1294-300. DMNH3PG RU https://www.ncbi.nlm.nih.gov/pubmed/?term=9732391 DMNH3PG DI DMNH3PG DMNH3PG DN Etoposide DMNH3PG MI DE4LYSA DMNH3PG MN Cytochrome P450 3A4 (CYP3A4) DMNH3PG MT DME DMNH3PG MA Metabolism DMNH3PG RN Effects of morin on the pharmacokinetics of etoposide in rats. Biopharm Drug Dispos. 2007 Apr;28(3):151-6. DMNH3PG RU https://www.ncbi.nlm.nih.gov/pubmed/?term=17315145 DMNH3PG DI DMNH3PG DMNH3PG DN Etoposide DMNH3PG MI DEIBDNY DMNH3PG MN Cytochrome P450 3A5 (CYP3A5) DMNH3PG MT DME DMNH3PG MA Metabolism DMNH3PG RN Kinetics and regulation of cytochrome P450-mediated etoposide metabolism. Drug Metab Dispos. 2004 Sep;32(9):993-1000. DMNH3PG RU https://www.ncbi.nlm.nih.gov/pubmed/?term=15319341 DMNH3PG DI DMNH3PG DMNH3PG DN Etoposide DMNH3PG MI TT0IHXV DMNH3PG MN DNA topoisomerase II (TOP2) DMNH3PG MT DTT DMNH3PG MA Modulator DMNH3PG RN Etoposide, topoisomerase II and cancer.Curr Med Chem Anticancer Agents.2005 Jul;5(4):363-72. DMNH3PG RU https://www.ncbi.nlm.nih.gov/pubmed/16101488 DMNH3PG DI DMNH3PG DMNH3PG DN Etoposide DMNH3PG MI DEK6079 DMNH3PG MN Glutathione S-transferase pi (GSTP1) DMNH3PG MT DME DMNH3PG MA Metabolism DMNH3PG RN Reactions of glutathione with the catechol, the ortho-quinone and the semi-quinone free radical of etoposide. Consequences for DNA inactivation. Biochem Pharmacol. 1992 Apr 15;43(8):1761-8. DMNH3PG RU https://www.ncbi.nlm.nih.gov/pubmed/?term=1315544 DMNH3PG DI DMNH3PG DMNH3PG DN Etoposide DMNH3PG MI DE3PKUG DMNH3PG MN Glutathione S-transferase theta-1 (GSTT1) DMNH3PG MT DME DMNH3PG MA Metabolism DMNH3PG RN Reactions of glutathione with the catechol, the ortho-quinone and the semi-quinone free radical of etoposide. Consequences for DNA inactivation. Biochem Pharmacol. 1992 Apr 15;43(8):1761-8. DMNH3PG RU https://www.ncbi.nlm.nih.gov/pubmed/?term=1315544 DMNH3PG DI DMNH3PG DMNH3PG DN Etoposide DMNH3PG MI DTSYQGK DMNH3PG MN Multidrug resistance-associated protein 1 (ABCC1) DMNH3PG MT DTP DMNH3PG MA Substrate DMNH3PG RN Multidrug resistance-associated protein-1 functional activity in Calu-3 cells. J Pharmacol Exp Ther. 2001 Sep;298(3):1199-205. DMNH3PG RU http://www.ncbi.nlm.nih.gov/pubmed/11504821 DMNH3PG DI DMNH3PG DMNH3PG DN Etoposide DMNH3PG MI DTFI42L DMNH3PG MN Multidrug resistance-associated protein 2 (ABCC2) DMNH3PG MT DTP DMNH3PG MA Substrate DMNH3PG RN Delineating the contribution of secretory transporters in the efflux of etoposide using Madin-Darby canine kidney (MDCK) cells overexpressing P-glycoprotein (Pgp), multidrug resistance-associated protein (MRP1), and canalicular multispecific organic anion transporter (cMOAT). Drug Metab Dispos. 2002 Apr;30(4):457-63. DMNH3PG RU http://www.ncbi.nlm.nih.gov/pubmed/11901101 DMNH3PG DI DMNH3PG DMNH3PG DN Etoposide DMNH3PG MI DTQ3ZHF DMNH3PG MN Multidrug resistance-associated protein 3 (ABCC3) DMNH3PG MT DTP DMNH3PG MA Substrate DMNH3PG RN Functional reconstitution of human ABCC3 into proteoliposomes reveals a transport mechanism with positive cooperativity. Biochemistry. 2009 May 26;48(20):4423-30. DMNH3PG RU http://www.ncbi.nlm.nih.gov/pubmed/19334674 DMNH3PG DI DMNH3PG DMNH3PG DN Etoposide DMNH3PG MI DT3D8F0 DMNH3PG MN Organic anion transporting polypeptide 1B1 (SLCO1B1) DMNH3PG MT DTP DMNH3PG MA Substrate DMNH3PG RN Identification of drugs and drug metabolites as substrates of multidrug resistance protein 2 (MRP2) using triple-transfected MDCK-OATP1B1-UGT1A1-MRP2 cells. Br J Pharmacol. 2012 Mar;165(6):1836-1847. DMNH3PG RU https://doi.org/10.1111/j.1476-5381.2011.01672.x DMNH3PG DI DMNH3PG DMNH3PG DN Etoposide DMNH3PG MI DT9C1TS DMNH3PG MN Organic anion transporting polypeptide 1B3 (SLCO1B3) DMNH3PG MT DTP DMNH3PG MA Substrate DMNH3PG RN Effect of pregnane X receptor ligands on transport mediated by human OATP1B1 and OATP1B3. Eur J Pharmacol. 2008 Apr 14;584(1):57-65. DMNH3PG RU http://www.ncbi.nlm.nih.gov/pubmed/18321482 DMNH3PG DI DMNH3PG DMNH3PG DN Etoposide DMNH3PG MI DTPFTEQ DMNH3PG MN Organic anion transporting polypeptide 2B1 (SLCO2B1) DMNH3PG MT DTP DMNH3PG MA Substrate DMNH3PG RN Identification of drugs and drug metabolites as substrates of multidrug resistance protein 2 (MRP2) using triple-transfected MDCK-OATP1B1-UGT1A1-MRP2 cells. Br J Pharmacol. 2012 Mar;165(6):1836-1847. DMNH3PG RU https://doi.org/10.1111/j.1476-5381.2011.01672.x DMNH3PG DI DMNH3PG DMNH3PG DN Etoposide DMNH3PG MI DTUGYRD DMNH3PG MN P-glycoprotein 1 (ABCB1) DMNH3PG MT DTP DMNH3PG MA Substrate DMNH3PG RN Efflux ratio cannot assess P-glycoprotein-mediated attenuation of absorptive transport: asymmetric effect of P-glycoprotein on absorptive and secretory transport across Caco-2 cell monolayers. Pharm Res. 2003 Aug;20(8):1200-9. DMNH3PG RU http://www.ncbi.nlm.nih.gov/pubmed/12948018 DMNH3PG DI DMNH3PG DMNH3PG DN Etoposide DMNH3PG MI DE073H6 DMNH3PG MN Prostaglandin G/H synthase 1 (COX-1) DMNH3PG MT DME DMNH3PG MA Metabolism DMNH3PG RN Peroxidative free radical formation and O-demethylation of etoposide(VP-16) and teniposide(VM-26). Biochem Biophys Res Commun. 1986 Feb 26;135(1):215-20. DMNH3PG RU https://www.ncbi.nlm.nih.gov/pubmed/?term=3006680 DMNH3PG DI DMNH3PG DMNH3PG DN Etoposide DMNH3PG MI DE492CE DMNH3PG MN Prostaglandin G/H synthase 2 (COX-2) DMNH3PG MT DME DMNH3PG MA Metabolism DMNH3PG RN Peroxidative free radical formation and O-demethylation of etoposide(VP-16) and teniposide(VM-26). Biochem Biophys Res Commun. 1986 Feb 26;135(1):215-20. DMNH3PG RU https://www.ncbi.nlm.nih.gov/pubmed/?term=3006680 DMNH3PG DI DMNH3PG DMNH3PG DN Etoposide DMNH3PG MI DEYGVN4 DMNH3PG MN UDP-glucuronosyltransferase 1A1 (UGT1A1) DMNH3PG MT DME DMNH3PG MA Metabolism DMNH3PG RN UDP-glucuronosyltransferase 1A1 is the principal enzyme responsible for etoposide glucuronidation in human liver and intestinal microsomes: structural characterization of phenolic and alcoholic glucuronides of etoposide and estimation of enzyme kinetics. Drug Metab Dispos. 2007 Mar;35(3):371-80. DMNH3PG RU https://www.ncbi.nlm.nih.gov/pubmed/?term=17151191 DM6A4NW DI DM6A4NW DM6A4NW DN Etoricoxib DM6A4NW MI DEJGDUW DM6A4NW MN Cytochrome P450 1A2 (CYP1A2) DM6A4NW MT DME DM6A4NW MA Metabolism DM6A4NW RN Role of human liver cytochrome P4503A in the metabolism of etoricoxib, a novel cyclooxygenase-2 selective inhibitor. Drug Metab Dispos. 2001 Jun;29(6):813-20. DM6A4NW RU https://www.ncbi.nlm.nih.gov/pubmed/?term=11353749 DM6A4NW DI DM6A4NW DM6A4NW DN Etoricoxib DM6A4NW MI DE5IED8 DM6A4NW MN Cytochrome P450 2C9 (CYP2C9) DM6A4NW MT DME DM6A4NW MA Metabolism DM6A4NW RN Role of human liver cytochrome P4503A in the metabolism of etoricoxib, a novel cyclooxygenase-2 selective inhibitor. Drug Metab Dispos. 2001 Jun;29(6):813-20. DM6A4NW RU https://www.ncbi.nlm.nih.gov/pubmed/?term=11353749 DM6A4NW DI DM6A4NW DM6A4NW DN Etoricoxib DM6A4NW MI DE4LYSA DM6A4NW MN Cytochrome P450 3A4 (CYP3A4) DM6A4NW MT DME DM6A4NW MA Metabolism DM6A4NW RN Role of human liver cytochrome P4503A in the metabolism of etoricoxib, a novel cyclooxygenase-2 selective inhibitor. Drug Metab Dispos. 2001 Jun;29(6):813-20. DM6A4NW RU https://www.ncbi.nlm.nih.gov/pubmed/?term=11353749 DM6A4NW DI DM6A4NW DM6A4NW DN Etoricoxib DM6A4NW MI TTVKILB DM6A4NW MN Prostaglandin G/H synthase 2 (COX-2) DM6A4NW MT DTT DM6A4NW MA Inhibitor DM6A4NW RN The effect of newer anti-rheumatic drugs on osteogenic cell proliferation: an in-vitro study. J Orthop Surg Res. 2009 May 26;4:17. DM6A4NW RU https://pubmed.ncbi.nlm.nih.gov/19470170 DMGV8QU DI DMGV8QU DMGV8QU DN Etravirine DMGV8QU MI DE5IED8 DMGV8QU MN Cytochrome P450 2C9 (CYP2C9) DMGV8QU MT DME DMGV8QU MA Metabolism DMGV8QU RN Pharmacokinetic interactions between etravirine and non-antiretroviral drugs. Clin Pharmacokinet. 2011 Jan;50(1):25-39. DMGV8QU RU https://www.ncbi.nlm.nih.gov/pubmed/?term=21142266 DMGV8QU DI DMGV8QU DMGV8QU DN Etravirine DMGV8QU MI DE4LYSA DMGV8QU MN Cytochrome P450 3A4 (CYP3A4) DMGV8QU MT DME DMGV8QU MA Metabolism DMGV8QU RN Pharmacokinetic interactions between etravirine and non-antiretroviral drugs. Clin Pharmacokinet. 2011 Jan;50(1):25-39. DMGV8QU RU https://www.ncbi.nlm.nih.gov/pubmed/?term=21142266 DMGV8QU DI DMGV8QU DMGV8QU DN Etravirine DMGV8QU MI TT84ETX DMGV8QU MN Human immunodeficiency virus Reverse transcriptase (HIV RT) DMGV8QU MT DTT DMGV8QU MA Modulator DMGV8QU RN 2008 FDA drug approvals. Nat Rev Drug Discov. 2009 Feb;8(2):93-6. DMGV8QU RU https://pubmed.ncbi.nlm.nih.gov/19180096 DMGV8QU DI DMGV8QU DMGV8QU DN Etravirine DMGV8QU MI DEGTFWK DMGV8QU MN Mephenytoin 4-hydroxylase (CYP2C19) DMGV8QU MT DME DMGV8QU MA Metabolism DMGV8QU RN Biotransformation of the antiretroviral drug etravirine: metabolite identification, reaction phenotyping, and characterization of autoinduction of cytochrome P450-dependent metabolism. Drug Metab Dispos. 2012 Apr;40(4):803-14. DMGV8QU RU https://www.ncbi.nlm.nih.gov/pubmed/?term=22269145 DMGV8QU DI DMGV8QU DMGV8QU DN Etravirine DMGV8QU MI DTQ3ZHF DMGV8QU MN Multidrug resistance-associated protein 3 (ABCC3) DMGV8QU MT DTP DMGV8QU MA Substrate DMGV8QU RN Interaction potential of etravirine with drug transporters assessed in vitro. Antimicrob Agents Chemother. 2011 Mar;55(3):1282-4. DMGV8QU RU http://www.ncbi.nlm.nih.gov/pubmed/21189339 DM2CZFA DI DM2CZFA DM2CZFA DN Etretinate DM2CZFA MI DEZT8FM DM2CZFA MN Retinoic acid 4-hydroxylase 26B1 (CYP26B1) DM2CZFA MT DME DM2CZFA MA Metabolism DM2CZFA RN Lipopolysaccharide opposes the induction of CYP26A1 and CYP26B1 gene expression by retinoic acid in the rat liver in vivo. Am J Physiol Gastrointest Liver Physiol. 2007 Apr;292(4):G1029-36. DM2CZFA RU https://www.ncbi.nlm.nih.gov/pubmed/?term=17185629 DM5GT1M DI DM5GT1M DM5GT1M DN EVANS BLUE DM5GT1M MI TTFNGC9 DM5GT1M MN Serum albumin (ALB) DM5GT1M MT DTT DM5GT1M MA Modulator DM5GT1M RN The ChEMBL database in 2017. Nucleic Acids Res. 2017 Jan 4;45(D1):D945-D954. DM5GT1M RU https://www.ncbi.nlm.nih.gov/pubmed/27899562 DM8X2EH DI DM8X2EH DM8X2EH DN Everolimus DM8X2EH MI DE4LYSA DM8X2EH MN Cytochrome P450 3A4 (CYP3A4) DM8X2EH MT DME DM8X2EH MA Metabolism DM8X2EH RN The evolving experience using everolimus in clinical transplantation. Transplant Proc. 2004 Mar;36(2 Suppl):495S-499S. DM8X2EH RU https://www.ncbi.nlm.nih.gov/pubmed/?term=15041395 DM8X2EH DI DM8X2EH DM8X2EH DN Everolimus DM8X2EH MI DTUGYRD DM8X2EH MN P-glycoprotein 1 (ABCB1) DM8X2EH MT DTP DM8X2EH MA Substrate DM8X2EH RN Closer to the Site of Action: Everolimus Concentrations in Peripheral Blood Mononuclear Cells Correlate Well With Whole Blood Concentrations. Ther Drug Monit. 2015 Oct;37(5):675-80. DM8X2EH RU http://www.ncbi.nlm.nih.gov/pubmed/25565673 DM8X2EH DI DM8X2EH DM8X2EH DN Everolimus DM8X2EH MI TTCJG29 DM8X2EH MN Serine/threonine-protein kinase mTOR (mTOR) DM8X2EH MT DTT DM8X2EH MA Inhibitor DM8X2EH RN Mammalian target of rapamycin, its mode of action and clinical response in metastatic clear cell carcinoma. Gan To Kagaku Ryoho. 2009 Jul;36(7):1076-9. DM8X2EH RU https://pubmed.ncbi.nlm.nih.gov/19620795 DMBLX7U DI DMBLX7U DMBLX7U DN Evinacumab DMBLX7U MI TTUO98L DMBLX7U MN Angiopoietin-related protein 3 (ANGPTL3) DMBLX7U MT DTT DMBLX7U MA Inhibitor DMBLX7U RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health Human Services. 2021 DMBLX7U RU https://www.accessdata.fda.gov/drugsatfda_docs/label/2021/761181s000lbl.pdf DM9HPW3 DI DM9HPW3 DM9HPW3 DN Exemestane DM9HPW3 MI TTSZLWK DM9HPW3 MN Aromatase (CYP19A1) DM9HPW3 MT DTT DM9HPW3 MA Inhibitor DM9HPW3 RN Aromatase inhibitors--theoretical concept and present experiences in the treatment of endometriosis. Zentralbl Gynakol. 2003 Jul-Aug;125(7-8):247-51. DM9HPW3 RU https://pubmed.ncbi.nlm.nih.gov/14505258 DM9HPW3 DI DM9HPW3 DM9HPW3 DN Exemestane DM9HPW3 MI DE4LYSA DM9HPW3 MN Cytochrome P450 3A4 (CYP3A4) DM9HPW3 MT DME DM9HPW3 MA Metabolism DM9HPW3 RN In vitro metabolism of exemestane by hepatic cytochrome P450s: impact of nonsynonymous polymorphisms on formation of the active metabolite 17beta-dihydroexemestane. Pharmacol Res Perspect. 2017 Apr 27;5(3):e00314. DM9HPW3 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=28603633 DMYHBKN DI DMYHBKN DMYHBKN DN Exenatide DMYHBKN MI DEKZQY6 DMYHBKN MN Dipeptidyl peptidase IV (DPP4) DMYHBKN MT DME DMYHBKN MA Metabolism DMYHBKN RN In vitro metabolic stability of exendin-4: pharmacokinetics and identification of cleavage products. PLoS One. 2015 Feb 27;10(2):e0116805. DMYHBKN RU https://www.ncbi.nlm.nih.gov/pubmed/?term=25723538 DMYHBKN DI DMYHBKN DMYHBKN DN Exenatide DMYHBKN MI TTVIMDE DMYHBKN MN Glucagon-like peptide 1 receptor (GLP1R) DMYHBKN MT DTT DMYHBKN MA Binder DMYHBKN RN Improved glycemic control and reduction of cardiometabolic risk factors in subjects with type 2 diabetes and metabolic syndrome treated with exenatide in a clinical practice setting. Diabetes TechnolTher. 2009 Jun;11(6):353-9. DMYHBKN RU https://pubmed.ncbi.nlm.nih.gov/19459763 DMHPRWG DI DMHPRWG DMHPRWG DN Exjade DMHPRWG MI TTUDR0C DMHPRWG MN Iron (Fe) DMHPRWG MT DTT DMHPRWG MA Modulator DMHPRWG RN Deferasirox : a review of its use in the management of transfusional chronic iron overload. Drugs. 2007;67(15):2211-30. DMHPRWG RU https://pubmed.ncbi.nlm.nih.gov/17927285 DM7A8TW DI DM7A8TW DM7A8TW DN Ezetimibe DM7A8TW MI DTJ0EW4 DM7A8TW MN Bile salt export pump (ABCB11) DM7A8TW MT DTP DM7A8TW MA Substrate DM7A8TW RN Early identification of clinically relevant drug interactions with the human bile salt export pump (BSEP/ABCB11). Toxicol Sci. 2013 Dec;136(2):328-43. DM7A8TW RU http://www.ncbi.nlm.nih.gov/pubmed/24014644 DM7A8TW DI DM7A8TW DM7A8TW DN Ezetimibe DM7A8TW MI DTI7UX6 DM7A8TW MN Breast cancer resistance protein (ABCG2) DM7A8TW MT DTP DM7A8TW MA Substrate DM7A8TW RN Complex pharmacokinetic behavior of ezetimibe depends on abcc2, abcc3, and abcg2. Drug Metab Dispos. 2009 Aug;37(8):1698-702. DM7A8TW RU http://www.ncbi.nlm.nih.gov/pubmed/19443695 DM7A8TW DI DM7A8TW DM7A8TW DN Ezetimibe DM7A8TW MI DE4LYSA DM7A8TW MN Cytochrome P450 3A4 (CYP3A4) DM7A8TW MT DME DM7A8TW MA Metabolism DM7A8TW RN Ezetimibe: a review of its metabolism, pharmacokinetics and drug interactions. Clin Pharmacokinet. 2005;44(5):467-94. DM7A8TW RU https://www.ncbi.nlm.nih.gov/pubmed/?term=15871634 DM7A8TW DI DM7A8TW DM7A8TW DN Ezetimibe DM7A8TW MI DTFI42L DM7A8TW MN Multidrug resistance-associated protein 2 (ABCC2) DM7A8TW MT DTP DM7A8TW MA Substrate DM7A8TW RN Intestinal expression of P-glycoprotein (ABCB1), multidrug resistance associated protein 2 (ABCC2), and uridine diphosphate-glucuronosyltransferase 1A1 predicts the disposition and modulates the effects of the cholesterol absorption inhibitor ezetimibe in humans. Clin Pharmacol Ther. 2006 Mar;79(3):206-17. DM7A8TW RU http://www.ncbi.nlm.nih.gov/pubmed/16513445 DM7A8TW DI DM7A8TW DM7A8TW DN Ezetimibe DM7A8TW MI DTQ3ZHF DM7A8TW MN Multidrug resistance-associated protein 3 (ABCC3) DM7A8TW MT DTP DM7A8TW MA Substrate DM7A8TW RN Complex pharmacokinetic behavior of ezetimibe depends on abcc2, abcc3, and abcg2. Drug Metab Dispos. 2009 Aug;37(8):1698-702. DM7A8TW RU http://www.ncbi.nlm.nih.gov/pubmed/19443695 DM7A8TW DI DM7A8TW DM7A8TW DN Ezetimibe DM7A8TW MI TTPD1CN DM7A8TW MN Niemann-Pick C1-like protein 1 (NPC1L1) DM7A8TW MT DTT DM7A8TW MA Inhibitor DM7A8TW RN Update on patented cholesterol absorption inhibitors. Expert Opin Ther Pat. 2009 Aug;19(8):1083-107. DM7A8TW RU https://pubmed.ncbi.nlm.nih.gov/19552506 DM7A8TW DI DM7A8TW DM7A8TW DN Ezetimibe DM7A8TW MI DT3D8F0 DM7A8TW MN Organic anion transporting polypeptide 1B1 (SLCO1B1) DM7A8TW MT DTP DM7A8TW MA Substrate DM7A8TW RN A LC-MS/MS method to quantify the novel cholesterol lowering drug ezetimibe in human serum, urine and feces in healthy subjects genotyped for SLCO1B1. J Chromatogr B Analyt Technol Biomed Life Sci. 2006 Jan 2;830(1):143-50. DM7A8TW RU http://www.ncbi.nlm.nih.gov/pubmed/16280261 DM7A8TW DI DM7A8TW DM7A8TW DN Ezetimibe DM7A8TW MI DTUGYRD DM7A8TW MN P-glycoprotein 1 (ABCB1) DM7A8TW MT DTP DM7A8TW MA Substrate DM7A8TW RN Pharmacokinetic and pharmacodynamic interactions between the immunosuppressant sirolimus and the lipid-lowering drug ezetimibe in healthy volunteers. Clin Pharmacol Ther. 2010 Jun;87(6):663-7. DM7A8TW RU http://www.ncbi.nlm.nih.gov/pubmed/20220747 DM7A8TW DI DM7A8TW DM7A8TW DN Ezetimibe DM7A8TW MI DEYGVN4 DM7A8TW MN UDP-glucuronosyltransferase 1A1 (UGT1A1) DM7A8TW MT DME DM7A8TW MA Metabolism DM7A8TW RN Ezetimibe: a review of its metabolism, pharmacokinetics and drug interactions. Clin Pharmacokinet. 2005;44(5):467-94. DM7A8TW RU https://www.ncbi.nlm.nih.gov/pubmed/?term=15871634 DM7A8TW DI DM7A8TW DM7A8TW DN Ezetimibe DM7A8TW MI DEF2WXN DM7A8TW MN UDP-glucuronosyltransferase 1A3 (UGT1A3) DM7A8TW MT DME DM7A8TW MA Metabolism DM7A8TW RN Drug interactions between the immunosuppressant tacrolimus and the cholesterol absorption inhibitor ezetimibe in healthy volunteers. Clin Pharmacol Ther. 2011 Apr;89(4):524-8. DM7A8TW RU https://www.ncbi.nlm.nih.gov/pubmed/?term=21368751 DM7A8TW DI DM7A8TW DM7A8TW DN Ezetimibe DM7A8TW MI DENZ6B1 DM7A8TW MN UDP-glucuronosyltransferase 2B15 (UGT2B15) DM7A8TW MT DME DM7A8TW MA Metabolism DM7A8TW RN Ezetimibe: a review of its metabolism, pharmacokinetics and drug interactions. Clin Pharmacokinet. 2005;44(5):467-94. DM7A8TW RU https://www.ncbi.nlm.nih.gov/pubmed/?term=15871634 DM7A8TW DI DM7A8TW DM7A8TW DN Ezetimibe DM7A8TW MI DEB3CV1 DM7A8TW MN UDP-glucuronosyltransferase 2B7 (UGT2B7) DM7A8TW MT DME DM7A8TW MA Metabolism DM7A8TW RN Ezetimibe: a review of its metabolism, pharmacokinetics and drug interactions. Clin Pharmacokinet. 2005;44(5):467-94. DM7A8TW RU https://www.ncbi.nlm.nih.gov/pubmed/?term=15871634 DMAB6PM DI DMAB6PM DMAB6PM DN Factor 8 DMAB6PM MI TT1290U DMAB6PM MN Coagulation factor VIII (F8) DMAB6PM MT DTT DMAB6PM MA Modulator DMAB6PM RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2607). DMAB6PM RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2607 DMZUW6P DI DMZUW6P DMZUW6P DN Factor viia DMZUW6P MI TTF0EGX DMZUW6P MN Coagulation factor VII (F7) DMZUW6P MT DTT DMZUW6P MA Modulator DMZUW6P RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2363). DMZUW6P RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2363 DM3C5GZ DI DM3C5GZ DM3C5GZ DN FADROZOLE DM3C5GZ MI TTSZLWK DM3C5GZ MN Aromatase (CYP19A1) DM3C5GZ MT DTT DM3C5GZ MA Inhibitor DM3C5GZ RN Enantioselective nonsteroidal aromatase inhibitors identified through a multidisciplinary medicinal chemistry approach. J Med Chem. 2005 Nov 17;48(23):7282-9. DM3C5GZ RU https://pubmed.ncbi.nlm.nih.gov/16279787 DM3C5GZ DI DM3C5GZ DM3C5GZ DN FADROZOLE DM3C5GZ MI TTIQUX7 DM3C5GZ MN Steroid 11-beta-hydroxylase (CYP11B1) DM3C5GZ MT DTT DM3C5GZ MA Inhibitor DM3C5GZ RN Synthesis, biological evaluation, and molecular modeling of 1-benzyl-1H-imidazoles as selective inhibitors of aldosterone synthase (CYP11B2). J Med Chem. 2010 Feb 25;53(4):1712-25. DM3C5GZ RU https://pubmed.ncbi.nlm.nih.gov/20121113 DMBI9ZJ DI DMBI9ZJ DMBI9ZJ DN Falecalcitrol DMBI9ZJ MI TTK59TV DMBI9ZJ MN Vitamin D3 receptor (VDR) DMBI9ZJ MT DTT DMBI9ZJ MA Agonist DMBI9ZJ RN Synthesis and biological evaluations of A-ring isomers of 26,26,26,27,27,27-hexafluoro-1,25-dihydroxyvitamin D3. Bioorg Med Chem. 2000 Aug;8(8):2157-66. DMBI9ZJ RU https://pubmed.ncbi.nlm.nih.gov/11003160 DMJHLSD DI DMJHLSD DMJHLSD DN Famciclovir DMJHLSD MI DE4LYSA DMJHLSD MN Cytochrome P450 3A4 (CYP3A4) DMJHLSD MT DME DMJHLSD MA Metabolism DMJHLSD RN Evidence that famciclovir (BRL 42810) and its associated metabolites do not inhibit the 6 beta-hydroxylation of testosterone in human liver microsomes. Drug Metab Dispos. 1993 Jan-Feb;21(1):18-23. DMJHLSD RU https://www.ncbi.nlm.nih.gov/pubmed/?term=8095215 DMJHLSD DI DMJHLSD DMJHLSD DN Famciclovir DMJHLSD MI TTIU7X1 DMJHLSD MN Herpes simplex virus DNA polymerase UL30 (HSV UL30) DMJHLSD MT DTT DMJHLSD MA Inhibitor DMJHLSD RN Penciclovir cream--improved topical treatment for herpes simplex infections. Skin Pharmacol Physiol. 2004 Sep-Oct;17(5):214-8. DMJHLSD RU https://pubmed.ncbi.nlm.nih.gov/15452407 DMJHLSD DI DMJHLSD DMJHLSD DN Famciclovir DMJHLSD MI DTUGYRD DMJHLSD MN P-glycoprotein 1 (ABCB1) DMJHLSD MT DTP DMJHLSD MA Substrate DMJHLSD RN Passive permeability and P-glycoprotein-mediated efflux differentiate central nervous system (CNS) and non-CNS marketed drugs. J Pharmacol Exp Ther. 2002 Dec;303(3):1029-37. DMJHLSD RU http://www.ncbi.nlm.nih.gov/pubmed/12438524 DMRL3AB DI DMRL3AB DMRL3AB DN Famotidine DMRL3AB MI TTQHJ1K DMRL3AB MN Histamine H2 receptor (H2R) DMRL3AB MT DTT DMRL3AB MA Antagonist DMRL3AB RN Histamine H1 and H2 receptor antagonists accelerate skin barrier repair and prevent epidermal hyperplasia induced by barrier disruption in a dry environment. J Invest Dermatol. 2001 Feb;116(2):261-5. DMRL3AB RU https://pubmed.ncbi.nlm.nih.gov/11180002 DMRL3AB DI DMRL3AB DMRL3AB DN Famotidine DMRL3AB MI DEGTFWK DMRL3AB MN Mephenytoin 4-hydroxylase (CYP2C19) DMRL3AB MT DME DMRL3AB MA Metabolism DMRL3AB RN Initial 48-hour acid inhibition by intravenous infusion of omeprazole, famotidine, or both in relation to cytochrome P450 2C19 genotype status. Clin Pharmacol Ther. 2006 Nov;80(5):539-48. DMRL3AB RU https://www.ncbi.nlm.nih.gov/pubmed/?term=17112810 DMRL3AB DI DMRL3AB DMRL3AB DN Famotidine DMRL3AB MI DTQ23VB DMRL3AB MN Organic anion transporter 1 (SLC22A6) DMRL3AB MT DTP DMRL3AB MA Substrate DMRL3AB RN Different transport properties between famotidine and cimetidine by human renal organic ion transporters (SLC22A). Eur J Pharmacol. 2004 Oct 25;503(1-3):25-30. DMRL3AB RU http://www.ncbi.nlm.nih.gov/pubmed/15496291 DMRL3AB DI DMRL3AB DMRL3AB DN Famotidine DMRL3AB MI DTVP67E DMRL3AB MN Organic anion transporter 3 (SLC22A8) DMRL3AB MT DTP DMRL3AB MA Substrate DMRL3AB RN A species difference in the transport activities of H2 receptor antagonists by rat and human renal organic anion and cation transporters. J Pharmacol Exp Ther. 2005 Oct;315(1):337-45. DMRL3AB RU http://www.ncbi.nlm.nih.gov/pubmed/16006492 DMRL3AB DI DMRL3AB DMRL3AB DN Famotidine DMRL3AB MI DT9IDPW DMRL3AB MN Organic cation transporter 2 (SLC22A2) DMRL3AB MT DTP DMRL3AB MA Substrate DMRL3AB RN A species difference in the transport activities of H2 receptor antagonists by rat and human renal organic anion and cation transporters. J Pharmacol Exp Ther. 2005 Oct;315(1):337-45. DMRL3AB RU http://www.ncbi.nlm.nih.gov/pubmed/16006492 DMX7A5V DI DMX7A5V DMX7A5V DN Faropenem DMX7A5V MI TT4ILYC DMX7A5V MN Bacterial Dihydropteroate synthetase (Bact folP) DMX7A5V MT DTT DMX7A5V MA Inhibitor DMX7A5V RN Emerging drugs for bacterial urinary tract infections. Expert Opin Emerg Drugs. 2005 May;10(2):275-98. DMX7A5V RU https://pubmed.ncbi.nlm.nih.gov/15934867 DMDEXQ0 DI DMDEXQ0 DMDEXQ0 DN Febuxostat DMDEXQ0 MI DEYGVN4 DMDEXQ0 MN UDP-glucuronosyltransferase 1A1 (UGT1A1) DMDEXQ0 MT DME DMDEXQ0 MA Metabolism DMDEXQ0 RN In vitro drug-drug interaction studies with febuxostat, a novel non-purine selective inhibitor of xanthine oxidase: plasma protein binding, identification of metabolic enzymes and cytochrome P450 inhibition. Xenobiotica. 2008 May;38(5):496-510. DMDEXQ0 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=18421623 DMDEXQ0 DI DMDEXQ0 DMDEXQ0 DN Febuxostat DMDEXQ0 MI TT7RJY8 DMDEXQ0 MN Xanthine dehydrogenase/oxidase (XDH) DMDEXQ0 MT DTT DMDEXQ0 MA Inhibitor DMDEXQ0 RN Clinical pipeline report, company report or official report of Takeda (2009). DMDEXQ0 RU http://www.takeda.com/pdf/usr/default/10_1_34992_2.pdf DM4ZBK6 DI DM4ZBK6 DM4ZBK6 DN Fedratinib DM4ZBK6 MI TTRMX3V DM4ZBK6 MN Janus kinase 2 (JAK-2) DM4ZBK6 MT DTT DM4ZBK6 MA Inhibitor DM4ZBK6 RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health Human Services. 2019 DM4ZBK6 RU https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/212327s000lbl.pdf DML2DCR DI DML2DCR DML2DCR DN Fedratinib hydrochloride DML2DCR MI DE4LYSA DML2DCR MN Cytochrome P450 3A4 (CYP3A4) DML2DCR MT DME DML2DCR MA Metabolism DML2DCR RN FDA label of Fedratinib. The 2020 official website of the U.S. Food and Drug Administration. DML2DCR RU https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/212327s000lbl.pdf DML2DCR DI DML2DCR DML2DCR DN Fedratinib hydrochloride DML2DCR MI DEP76YL DML2DCR MN Dimethylaniline oxidase 3 (FMO3) DML2DCR MT DME DML2DCR MA Metabolism DML2DCR RN FDA label of Fedratinib. The 2020 official website of the U.S. Food and Drug Administration. DML2DCR RU https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/212327s000lbl.pdf DML2DCR DI DML2DCR DML2DCR DN Fedratinib hydrochloride DML2DCR MI DEGTFWK DML2DCR MN Mephenytoin 4-hydroxylase (CYP2C19) DML2DCR MT DME DML2DCR MA Metabolism DML2DCR RN FDA label of Fedratinib. The 2020 official website of the U.S. Food and Drug Administration. DML2DCR RU https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/212327s000lbl.pdf DM1V5ZS DI DM1V5ZS DM1V5ZS DN Felbamate DM1V5ZS MI DEVDYN7 DM1V5ZS MN Cytochrome P450 2E1 (CYP2E1) DM1V5ZS MT DME DM1V5ZS MA Metabolism DM1V5ZS RN Summary of information on human CYP enzymes: human P450 metabolism data. Drug Metab Rev. 2002 Feb-May;34(1-2):83-448. DM1V5ZS RU https://www.ncbi.nlm.nih.gov/pubmed/?term=11996015 DM1V5ZS DI DM1V5ZS DM1V5ZS DN Felbamate DM1V5ZS MI DE4LYSA DM1V5ZS MN Cytochrome P450 3A4 (CYP3A4) DM1V5ZS MT DME DM1V5ZS MA Metabolism DM1V5ZS RN A mechanistic approach to antiepileptic drug interactions. Ann Pharmacother. 1998 May;32(5):554-63. DM1V5ZS RU https://www.ncbi.nlm.nih.gov/pubmed/?term=9606477 DM1V5ZS DI DM1V5ZS DM1V5ZS DN Felbamate DM1V5ZS MI TT9IK2Z DM1V5ZS MN N-methyl-D-aspartate receptor (NMDAR) DM1V5ZS MT DTT DM1V5ZS MA Antagonist DM1V5ZS RN Molecular determinants of the anticonvulsant felbamate binding site in the N-methyl-D-aspartate receptor. J Med Chem. 2008 Mar 27;51(6):1534-45. DM1V5ZS RU https://pubmed.ncbi.nlm.nih.gov/18311896 DMKZEIB DI DMKZEIB DMKZEIB DN Felbinac DMKZEIB MI TTK0943 DMKZEIB MN Prostaglandin G/H synthase (COX) DMKZEIB MT DTT DMKZEIB MA Modulator DMKZEIB RN A review of the effects of fenbufen and a metabolite, biphenylacetic acid, on platelet biochemistry and function. Arzneimittelforschung. 1980;30(4A):702-7. DMKZEIB RU https://pubmed.ncbi.nlm.nih.gov/6254545 DMOSW35 DI DMOSW35 DMOSW35 DN Felodipine DMOSW35 MI TT5HONZ DMOSW35 MN Calcium channel unspecific (CaC) DMOSW35 MT DTT DMOSW35 MA Blocker DMOSW35 RN Molecular pharmacology of human Cav3.2 T-type Ca2+ channels: block by antihypertensives, antiarrhythmics, and their analogs. J Pharmacol Exp Ther. 2009 Feb;328(2):621-7. DMOSW35 RU https://pubmed.ncbi.nlm.nih.gov/18974361 DMOSW35 DI DMOSW35 DMOSW35 DN Felodipine DMOSW35 MI DE4LYSA DMOSW35 MN Cytochrome P450 3A4 (CYP3A4) DMOSW35 MT DME DMOSW35 MA Metabolism DMOSW35 RN Drug interactions with calcium channel blockers: possible involvement of metabolite-intermediate complexation with CYP3A. Drug Metab Dispos. 2000 Feb;28(2):125-30. DMOSW35 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=10640508 DMOSW35 DI DMOSW35 DMOSW35 DN Felodipine DMOSW35 MI DEIBDNY DMOSW35 MN Cytochrome P450 3A5 (CYP3A5) DMOSW35 MT DME DMOSW35 MA Metabolism DMOSW35 RN Drug Interactions Flockhart Table DMOSW35 RU https://drug-interactions.medicine.iu.edu/Main-Table.aspx DMOSW35 DI DMOSW35 DMOSW35 DN Felodipine DMOSW35 MI DERD86B DMOSW35 MN Cytochrome P450 3A7 (CYP3A7) DMOSW35 MT DME DMOSW35 MA Metabolism DMOSW35 RN Drug Interactions Flockhart Table DMOSW35 RU https://drug-interactions.medicine.iu.edu/Main-Table.aspx DMOSW35 DI DMOSW35 DMOSW35 DN Felodipine DMOSW35 MI DTUGYRD DMOSW35 MN P-glycoprotein 1 (ABCB1) DMOSW35 MT DTP DMOSW35 MA Substrate DMOSW35 RN The influence of CYP3A5*3 and BCRPC421A genetic polymorphisms on the pharmacokinetics of felodipine in healthy Chinese volunteers. J Clin Pharm Ther. 2017 Jun;42(3):345-349. DMOSW35 RU http://www.ncbi.nlm.nih.gov/pubmed/28244604 DMHLP9C DI DMHLP9C DMHLP9C DN Felypressin DMHLP9C MI TT4TFGN DMHLP9C MN Vasopressin V1a receptor (V1AR) DMHLP9C MT DTT DMHLP9C MA Agonist DMHLP9C RN Peptide and non-peptide agonists and antagonists for the vasopressin and oxytocin V1a, V1b, V2 and OT receptors: research tools and potential therapeutic agents. Prog Brain Res. 2008;170:473-512. DMHLP9C RU https://pubmed.ncbi.nlm.nih.gov/18655903 DMXGDFK DI DMXGDFK DMXGDFK DN Fenbufen DMXGDFK MI TT8NGED DMXGDFK MN Prostaglandin G/H synthase 1 (COX-1) DMXGDFK MT DTT DMXGDFK MA Inhibitor DMXGDFK RN Fenbufen based 3-[5-(substituted aryl)-1,3,4-oxadiazol-2-yl]-1-(biphenyl-4-yl)propan-1-ones as safer antiinflammatory and analgesic agents. Eur J Med Chem. 2009 Sep;44(9):3798-804. DMXGDFK RU https://pubmed.ncbi.nlm.nih.gov/19457595 DMXGDFK DI DMXGDFK DMXGDFK DN Fenbufen DMXGDFK MI TTVKILB DMXGDFK MN Prostaglandin G/H synthase 2 (COX-2) DMXGDFK MT DTT DMXGDFK MA Inhibitor DMXGDFK RN Fenbufen based 3-[5-(substituted aryl)-1,3,4-oxadiazol-2-yl]-1-(biphenyl-4-yl)propan-1-ones as safer antiinflammatory and analgesic agents. Eur J Med Chem. 2009 Sep;44(9):3798-804. DMXGDFK RU https://pubmed.ncbi.nlm.nih.gov/19457595 DM0LRU9 DI DM0LRU9 DM0LRU9 DN Fendrix DM0LRU9 MI TT3J5ZI DM0LRU9 MN Cell mediated immunity response (CMIR) DM0LRU9 MT DTT DM0LRU9 RN Revaccination with Fendrix or HBVaxPro results in better response rates than does revaccination with three doses of Engerix-B in previous non-responders. Vaccine. 2012 Nov 6;30(48):6734-7. DM0LRU9 RU https://pubmed.ncbi.nlm.nih.gov/22981848 DMFKXDY DI DMFKXDY DMFKXDY DN Fenofibrate DMFKXDY MI DE4LYSA DMFKXDY MN Cytochrome P450 3A4 (CYP3A4) DMFKXDY MT DME DMFKXDY MA Metabolism DMFKXDY RN Clinical pharmacokinetics of fibric acid derivatives (fibrates). Clin Pharmacokinet. 1998 Feb;34(2):155-62. DMFKXDY RU https://www.ncbi.nlm.nih.gov/pubmed/?term=9515185 DMFKXDY DI DMFKXDY DMFKXDY DN Fenofibrate DMFKXDY MI TTJ584C DMFKXDY MN Peroxisome proliferator-activated receptor alpha (PPARA) DMFKXDY MT DTT DMFKXDY MA Agonist DMFKXDY RN Peroxisome proliferator-activated receptor alpha activators improve insulin sensitivity and reduce adiposity. J Biol Chem. 2000 Jun 2;275(22):16638-42. DMFKXDY RU https://pubmed.ncbi.nlm.nih.gov/10828060 DMFKXDY DI DMFKXDY DMFKXDY DN Fenofibrate DMFKXDY MI DE85D2P DMFKXDY MN UDP-glucuronosyltransferase 1A9 (UGT1A9) DMFKXDY MT DME DMFKXDY MA Metabolism DMFKXDY RN Drug-drug interactions for UDP-glucuronosyltransferase substrates: a pharmacokinetic explanation for typically observed low exposure (AUCi/AUC) ratios. Drug Metab Dispos. 2004 Nov;32(11):1201-8. DMFKXDY RU https://www.ncbi.nlm.nih.gov/pubmed/?term=15304429 DMGO2MC DI DMGO2MC DMGO2MC DN Fenofibric acid DMGO2MC MI DE7WS3H DMGO2MC MN Aldo-keto reductase 1B1 (AKR1B1) DMGO2MC MT DME DMGO2MC MA Metabolism DMGO2MC RN In vitro metabolism of fenofibric acid by carbonyl reducing enzymes. Chem Biol Interact. 2016 Oct 25;258:153-8. DMGO2MC RU https://www.ncbi.nlm.nih.gov/pubmed/?term=27599626 DMGO2MC DI DMGO2MC DMGO2MC DN Fenofibric acid DMGO2MC MI DE7P2FB DMGO2MC MN Aldo-keto reductase 1C1 (AKR1C1) DMGO2MC MT DME DMGO2MC MA Metabolism DMGO2MC RN In vitro metabolism of fenofibric acid by carbonyl reducing enzymes. Chem Biol Interact. 2016 Oct 25;258:153-8. DMGO2MC RU https://www.ncbi.nlm.nih.gov/pubmed/?term=27599626 DMGO2MC DI DMGO2MC DMGO2MC DN Fenofibric acid DMGO2MC MI DEOY5ZM DMGO2MC MN Aldo-keto reductase 1C2 (AKR1C2) DMGO2MC MT DME DMGO2MC MA Metabolism DMGO2MC RN In vitro metabolism of fenofibric acid by carbonyl reducing enzymes. Chem Biol Interact. 2016 Oct 25;258:153-8. DMGO2MC RU https://www.ncbi.nlm.nih.gov/pubmed/?term=27599626 DMGO2MC DI DMGO2MC DMGO2MC DN Fenofibric acid DMGO2MC MI DEGQTXO DMGO2MC MN Aldo-keto reductase 1C3 (AKR1C3) DMGO2MC MT DME DMGO2MC MA Metabolism DMGO2MC RN In vitro metabolism of fenofibric acid by carbonyl reducing enzymes. Chem Biol Interact. 2016 Oct 25;258:153-8. DMGO2MC RU https://www.ncbi.nlm.nih.gov/pubmed/?term=27599626 DMGO2MC DI DMGO2MC DMGO2MC DN Fenofibric acid DMGO2MC MI DT61TWI DMGO2MC MN ATP-binding cassette sub-family A member 1 (ABCA1) DMGO2MC MT DTP DMGO2MC MA Substrate DMGO2MC RN Fenofibric acid, an active form of fenofibrate, increases apolipoprotein A-I-mediated high-density lipoprotein biogenesis by enhancing transcription of ATP-binding cassette transporter A1 gene in a liver X receptor-dependent manner. Arterioscler Thromb Vasc Biol. 2005 Jun;25(6):1193-7. DMGO2MC RU http://www.ncbi.nlm.nih.gov/pubmed/15790930 DMGO2MC DI DMGO2MC DMGO2MC DN Fenofibric acid DMGO2MC MI TTIV96N DMGO2MC MN Fatty acid-binding protein 1 (FABP1) DMGO2MC MT DTT DMGO2MC MA Inhibitor DMGO2MC RN Characterization of the drug binding specificity of rat liver fatty acid binding protein. J Med Chem. 2008 Jul 10;51(13):3755-64. DMGO2MC RU https://pubmed.ncbi.nlm.nih.gov/18533710 DMGO2MC DI DMGO2MC DMGO2MC DN Fenofibric acid DMGO2MC MI DE9JFMC DMGO2MC MN NADPH-dependent carbonyl reductase 1 (CBR1) DMGO2MC MT DME DMGO2MC MA Metabolism DMGO2MC RN In vitro metabolism of fenofibric acid by carbonyl reducing enzymes. Chem Biol Interact. 2016 Oct 25;258:153-8. DMGO2MC RU https://www.ncbi.nlm.nih.gov/pubmed/?term=27599626 DMFAOKP DI DMFAOKP DMFAOKP DN Fenoldopam DMFAOKP MI TTZFYLI DMFAOKP MN Dopamine D1 receptor (D1R) DMFAOKP MT DTT DMFAOKP MA Agonist DMFAOKP RN Etiology of iodinated radiocontrast nephrotoxicity and its attenuation by beraprost. Yakugaku Zasshi. 2008 Jul;128(7):1023-9. DMFAOKP RU https://pubmed.ncbi.nlm.nih.gov/18591870 DML5VQ0 DI DML5VQ0 DML5VQ0 DN Fenoprofen DML5VQ0 MI TTK0943 DML5VQ0 MN Prostaglandin G/H synthase (COX) DML5VQ0 MT DTT DML5VQ0 MA Inhibitor DML5VQ0 RN The aryl propionic acid R-flurbiprofen selectively induces p75NTR-dependent decreased survival of prostate tumor cells. Cancer Res. 2007 Apr 1;67(7):3254-62. DML5VQ0 RU https://pubmed.ncbi.nlm.nih.gov/17409433 DMIP3ZV DI DMIP3ZV DMIP3ZV DN Fenoterol DMIP3ZV MI TT2CJVK DMIP3ZV MN Adrenergic receptor beta-2 (ADRB2) DMIP3ZV MT DTT DMIP3ZV MA Agonist DMIP3ZV RN Functional alpha1- and beta2-adrenergic receptors in human osteoblasts. J Cell Physiol. 2009 Jul;220(1):267-75. DMIP3ZV RU https://pubmed.ncbi.nlm.nih.gov/19334040 DMIP3ZV DI DMIP3ZV DMIP3ZV DN Fenoterol DMIP3ZV MI DTT79CX DMIP3ZV MN Organic cation transporter 1 (SLC22A1) DMIP3ZV MT DTP DMIP3ZV MA Substrate DMIP3ZV RN Identification of novel substrates and structure-activity relationship of cellular uptake mediated by human organic cation transporters 1 and 2. J Med Chem. 2013 Sep 26;56(18):7232-42. DMIP3ZV RU http://www.ncbi.nlm.nih.gov/pubmed/23984907 DM8WAHT DI DM8WAHT DM8WAHT DN Fentanyl DM8WAHT MI DE4LYSA DM8WAHT MN Cytochrome P450 3A4 (CYP3A4) DM8WAHT MT DME DM8WAHT MA Metabolism DM8WAHT RN Three-dimensional-quantitative structure activity relationship analysis of cytochrome P-450 3A4 substrates. J Pharmacol Exp Ther. 1999 Oct;291(1):424-33. DM8WAHT RU https://www.ncbi.nlm.nih.gov/pubmed/?term=10490933 DM8WAHT DI DM8WAHT DM8WAHT DN Fentanyl DM8WAHT MI DEIBDNY DM8WAHT MN Cytochrome P450 3A5 (CYP3A5) DM8WAHT MT DME DM8WAHT MA Metabolism DM8WAHT RN Pharmacogenomics as molecular autopsy for forensic toxicology: genotyping cytochrome P450 3A4*1B and 3A5*3 for 25 fentanyl cases. J Anal Toxicol. 2005 Oct;29(7):590-8. DM8WAHT RU https://www.ncbi.nlm.nih.gov/pubmed/?term=16419387 DM8WAHT DI DM8WAHT DM8WAHT DN Fentanyl DM8WAHT MI DERD86B DM8WAHT MN Cytochrome P450 3A7 (CYP3A7) DM8WAHT MT DME DM8WAHT MA Metabolism DM8WAHT RN Drug Interactions Flockhart Table DM8WAHT RU https://drug-interactions.medicine.iu.edu/Main-Table.aspx DM8WAHT DI DM8WAHT DM8WAHT DN Fentanyl DM8WAHT MI TTKWM86 DM8WAHT MN Opioid receptor mu (MOP) DM8WAHT MT DTT DM8WAHT MA Modulator DM8WAHT RN The ChEMBL database in 2017. Nucleic Acids Res. 2017 Jan 4;45(D1):D945-D954. DM8WAHT RU https://www.ncbi.nlm.nih.gov/pubmed/27899562 DM8WAHT DI DM8WAHT DM8WAHT DN Fentanyl DM8WAHT MI DTUGYRD DM8WAHT MN P-glycoprotein 1 (ABCB1) DM8WAHT MT DTP DM8WAHT MA Substrate DM8WAHT RN Mammalian drug efflux transporters of the ATP binding cassette (ABC) family in multidrug resistance: A review of the past decade. Cancer Lett. 2016 Jan 1;370(1):153-64. DM8WAHT RU http://www.ncbi.nlm.nih.gov/pubmed/26499806 DM13495 DI DM13495 DM13495 DN Fesoterodine fumarate DM13495 MI DECB0K3 DM13495 MN Cytochrome P450 2D6 (CYP2D6) DM13495 MT DME DM13495 MA Metabolism DM13495 RN Effects of the moderate CYP3A4 inhibitor, fluconazole, on the pharmacokinetics of fesoterodine in healthy subjects. Br J Clin Pharmacol. 2011 Aug;72(2):263-9. DM13495 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=21545485 DM13495 DI DM13495 DM13495 DN Fesoterodine fumarate DM13495 MI DE4LYSA DM13495 MN Cytochrome P450 3A4 (CYP3A4) DM13495 MT DME DM13495 MA Metabolism DM13495 RN Effects of the moderate CYP3A4 inhibitor, fluconazole, on the pharmacokinetics of fesoterodine in healthy subjects. Br J Clin Pharmacol. 2011 Aug;72(2):263-9. DM13495 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=21545485 DM13495 DI DM13495 DM13495 DN Fesoterodine fumarate DM13495 MI TTZ9SOR DM13495 MN Muscarinic acetylcholine receptor M1 (CHRM1) DM13495 MT DTT DM13495 MA Modulator DM13495 RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015 DM13495 RU https://www.accessdata.fda.gov/scripts/cder/drugsatfda/ DM13495 DI DM13495 DM13495 DN Fesoterodine fumarate DM13495 MI DTUGYRD DM13495 MN P-glycoprotein 1 (ABCB1) DM13495 MT DTP DM13495 MA Substrate DM13495 RN Blood-brain barrier permeation and efflux exclusion of anticholinergics used in the treatment of overactive bladder. Drugs Aging. 2012 Apr 1;29(4):259-73. DM13495 RU http://www.ncbi.nlm.nih.gov/pubmed/22390261 DM17ONX DI DM17ONX DM17ONX DN Fexofenadine DM17ONX MI TTTIBOJ DM17ONX MN Histamine H1 receptor (H1R) DM17ONX MT DTT DM17ONX MA Antagonist DM17ONX RN Update on prescription and over-the-counter histamine inverse agonists in rhinitis therapy. Curr Allergy Asthma Rep. 2009 Mar;9(2):140-8. DM17ONX RU https://pubmed.ncbi.nlm.nih.gov/19210904 DM17ONX DI DM17ONX DM17ONX DN Fexofenadine DM17ONX MI DTQ3ZHF DM17ONX MN Multidrug resistance-associated protein 3 (ABCC3) DM17ONX MT DTP DM17ONX MA Substrate DM17ONX RN Involvement of multiple efflux transporters in hepatic disposition of fexofenadine. Mol Pharmacol. 2008 May;73(5):1474-83. DM17ONX RU http://www.ncbi.nlm.nih.gov/pubmed/18245269 DM17ONX DI DM17ONX DM17ONX DN Fexofenadine DM17ONX MI DTE2B1D DM17ONX MN Organic anion transporting polypeptide 1A2 (SLCO1A2) DM17ONX MT DTP DM17ONX MA Substrate DM17ONX RN Influence of the flavonoids apigenin, kaempferol, and quercetin on the function of organic anion transporting polypeptides 1A2 and 2B1. Biochem Pharmacol. 2010 Dec 1;80(11):1746-53. DM17ONX RU http://www.ncbi.nlm.nih.gov/pubmed/20797388 DM17ONX DI DM17ONX DM17ONX DN Fexofenadine DM17ONX MI DT9C1TS DM17ONX MN Organic anion transporting polypeptide 1B3 (SLCO1B3) DM17ONX MT DTP DM17ONX MA Substrate DM17ONX RN Contribution of OATP (organic anion-transporting polypeptide) family transporters to the hepatic uptake of fexofenadine in humans. Drug Metab Dispos. 2005 Oct;33(10):1477-81. DM17ONX RU http://www.ncbi.nlm.nih.gov/pubmed/16014768 DM17ONX DI DM17ONX DM17ONX DN Fexofenadine DM17ONX MI DTPFTEQ DM17ONX MN Organic anion transporting polypeptide 2B1 (SLCO2B1) DM17ONX MT DTP DM17ONX MA Substrate DM17ONX RN The effects of the SLCO2B1 c.1457C>T polymorphism and apple juice on the pharmacokinetics of fexofenadine and midazolam in humans. Pharmacogenet Genomics. 2011 Feb;21(2):84-93. DM17ONX RU http://www.ncbi.nlm.nih.gov/pubmed/21280267 DM17ONX DI DM17ONX DM17ONX DN Fexofenadine DM17ONX MI DTT79CX DM17ONX MN Organic cation transporter 1 (SLC22A1) DM17ONX MT DTP DM17ONX MA Substrate DM17ONX RN Intestinal drug transporter expression and the impact of grapefruit juice in humans. Clin Pharmacol Ther. 2007 Mar;81(3):362-70. DM17ONX RU https://doi.org/10.1038/sj.clpt.6100056 DM17ONX DI DM17ONX DM17ONX DN Fexofenadine DM17ONX MI DTUGYRD DM17ONX MN P-glycoprotein 1 (ABCB1) DM17ONX MT DTP DM17ONX MA Substrate DM17ONX RN Effect of itraconazole on the pharmacokinetics and pharmacodynamics of fexofenadine in relation to the MDR1 genetic polymorphism. Clin Pharmacol Ther. 2005 Aug;78(2):191-201. DM17ONX RU http://www.ncbi.nlm.nih.gov/pubmed/16084853 DM9Q8SO DI DM9Q8SO DM9Q8SO DN Fibrinolysin DM9Q8SO MI TTWODQF DM9Q8SO MN Fibrin (FG) DM9Q8SO MT DTT DM9Q8SO MA Modulator DM9Q8SO RN FIBRINOLYSIN, FIBRIN AND HYALINE MEMBRANES. Pediatrics. 1963 Nov;32:940-2. DM9Q8SO RU https://pubmed.ncbi.nlm.nih.gov/14075642 DMFP6MV DI DMFP6MV DMFP6MV DN Fidaxomicin DMFP6MV MI TTIJ5EB DMFP6MV MN Bacterial RNA polymerase switch region (Bact RNAP-SR) DMFP6MV MT DTT DMFP6MV MA Modulator DMFP6MV RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015 DMFP6MV RU https://www.accessdata.fda.gov/scripts/cder/drugsatfda/ DMZEONG DI DMZEONG DMZEONG DN Finafloxacin DMZEONG MI TTN6J5F DMZEONG MN Bacterial DNA gyrase (Bact gyrase) DMZEONG MT DTT DMZEONG MA Modulator DMZEONG RN 2014 FDA drug approvals. Nat Rev Drug Discov. 2015 Feb;14(2):77-81. DMZEONG RU https://pubmed.ncbi.nlm.nih.gov/25633781 DMZEONG DI DMZEONG DMZEONG DN Finafloxacin DMZEONG MI TTIXTO3 DMZEONG MN Staphylococcus Topoisomerase IV (Stap-coc parC) DMZEONG MT DTT DMZEONG MA Modulator DMZEONG RN 2014 FDA drug approvals. Nat Rev Drug Discov. 2015 Feb;14(2):77-81. DMZEONG RU https://pubmed.ncbi.nlm.nih.gov/25633781 DMWV3TZ DI DMWV3TZ DMWV3TZ DN Finasteride DMWV3TZ MI DE4LYSA DMWV3TZ MN Cytochrome P450 3A4 (CYP3A4) DMWV3TZ MT DME DMWV3TZ MA Metabolism DMWV3TZ RN Summary of information on human CYP enzymes: human P450 metabolism data. Drug Metab Rev. 2002 Feb-May;34(1-2):83-448. DMWV3TZ RU https://www.ncbi.nlm.nih.gov/pubmed/?term=11996015 DMWV3TZ DI DMWV3TZ DMWV3TZ DN Finasteride DMWV3TZ MI DEIBDNY DMWV3TZ MN Cytochrome P450 3A5 (CYP3A5) DMWV3TZ MT DME DMWV3TZ MA Metabolism DMWV3TZ RN Drug Interactions Flockhart Table DMWV3TZ RU https://drug-interactions.medicine.iu.edu/Main-Table.aspx DMWV3TZ DI DMWV3TZ DMWV3TZ DN Finasteride DMWV3TZ MI DERD86B DMWV3TZ MN Cytochrome P450 3A7 (CYP3A7) DMWV3TZ MT DME DMWV3TZ MA Metabolism DMWV3TZ RN Drug Interactions Flockhart Table DMWV3TZ RU https://drug-interactions.medicine.iu.edu/Main-Table.aspx DMWV3TZ DI DMWV3TZ DMWV3TZ DN Finasteride DMWV3TZ MI TT2A0DR DMWV3TZ MN Oxo-5-alpha-steroid 4-dehydrogenase (SRD5A) DMWV3TZ MT DTT DMWV3TZ MA Inhibitor DMWV3TZ RN The role of 5-alpha reductase inhibitors in prostate pathophysiology: Is there an additional advantage to inhibition of type 1 isoenzyme Can Urol Assoc J. 2009 Jun;3(3 Suppl 2):S109-14. DMWV3TZ RU https://pubmed.ncbi.nlm.nih.gov/19543428 DMWV3TZ DI DMWV3TZ DMWV3TZ DN Finasteride DMWV3TZ MI TTT02K8 DMWV3TZ MN Steroid 5-alpha-reductase 2 (SRD5A2) DMWV3TZ MT DTT DMWV3TZ MA Inhibitor DMWV3TZ RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMWV3TZ RU http://phrma-docs.phrma.org/files/dmfile/MID_Skin_Diseases_2018_9_FINAL.pdf DM5JVAN DI DM5JVAN DM5JVAN DN Fingolimod DM5JVAN MI DED26GV DM5JVAN MN Cytochrome P450 4F12 (CYP4F12) DM5JVAN MT DME DM5JVAN MA Metabolism DM5JVAN RN CYP4F enzymes are responsible for the elimination of fingolimod (FTY720), a novel treatment of relapsing multiple sclerosis. Drug Metab Dispos. 2011 Feb;39(2):191-8. DM5JVAN RU https://www.ncbi.nlm.nih.gov/pubmed/?term=21045201 DM5JVAN DI DM5JVAN DM5JVAN DN Fingolimod DM5JVAN MI DE3GT9C DM5JVAN MN Cytochrome P450 4F2 (CYP4F2) DM5JVAN MT DME DM5JVAN MA Metabolism DM5JVAN RN CYP4F enzymes are responsible for the elimination of fingolimod (FTY720), a novel treatment of relapsing multiple sclerosis. Drug Metab Dispos. 2011 Feb;39(2):191-8. DM5JVAN RU https://www.ncbi.nlm.nih.gov/pubmed/?term=21045201 DM5JVAN DI DM5JVAN DM5JVAN DN Fingolimod DM5JVAN MI TT9JZCK DM5JVAN MN Sphingosine-1-phosphate receptor 1 (S1PR1) DM5JVAN MT DTT DM5JVAN MA Modulator DM5JVAN RN Mullard A: 2010 FDA drug approvals. Nat Rev Drug Discov. 2011 Feb;10(2):82-5. DM5JVAN RU https://pubmed.ncbi.nlm.nih.gov/21283092 DMKV4NL DI DMKV4NL DMKV4NL DN Flavoxate DMKV4NL MI TTH18TF DMKV4NL MN Muscarinic acetylcholine receptor M5 (CHRM5) DMKV4NL MT DTT DMKV4NL MA Antagonist DMKV4NL RN Brain pertussis toxin-sensitive G proteins are involved in the flavoxate hydrochloride-induced suppression of the micturition reflex in rats. Brain Res. 1996 Jul 15;727(1-2):91-8. DMKV4NL RU https://pubmed.ncbi.nlm.nih.gov/8842386 DMSQDLE DI DMSQDLE DMSQDLE DN Flecainide DMSQDLE MI DEJGDUW DMSQDLE MN Cytochrome P450 1A2 (CYP1A2) DMSQDLE MT DME DMSQDLE MA Metabolism DMSQDLE RN Flecainide: current status and perspectives in arrhythmia management. World J Cardiol. 2015 Feb 26;7(2):76-85. DMSQDLE RU https://www.ncbi.nlm.nih.gov/pubmed/?term=25717355 DMSQDLE DI DMSQDLE DMSQDLE DN Flecainide DMSQDLE MI DECB0K3 DMSQDLE MN Cytochrome P450 2D6 (CYP2D6) DMSQDLE MT DME DMSQDLE MA Metabolism DMSQDLE RN Flecainide: current status and perspectives in arrhythmia management. World J Cardiol. 2015 Feb 26;7(2):76-85. DMSQDLE RU https://www.ncbi.nlm.nih.gov/pubmed/?term=25717355 DMSQDLE DI DMSQDLE DMSQDLE DN Flecainide DMSQDLE MI TT05DLS DMSQDLE MN E3 ubiquitin-protein ligase COP1 (RFWD2) DMSQDLE MT DTT DMSQDLE MA Modulator DMSQDLE RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. DMSQDLE RU https://www.fda.gov/ DMSQDLE DI DMSQDLE DMSQDLE DN Flecainide DMSQDLE MI TTN9VTF DMSQDLE MN Voltage-gated sodium channel alpha Nav1.9 (SCN11A) DMSQDLE MT DTT DMSQDLE MA Blocker DMSQDLE RN New antiarrhythmic agents for atrial fibrillation and atrial flutter. Expert Opin Emerg Drugs. 2005 May;10(2):311-22. DMSQDLE RU https://pubmed.ncbi.nlm.nih.gov/15934869 DMXGQYZ DI DMXGQYZ DMXGQYZ DN Fleroxacin DMXGQYZ MI TT0IHXV DMXGQYZ MN DNA topoisomerase II (TOP2) DMXGQYZ MT DTT DMXGQYZ MA Inhibitor DMXGQYZ RN Fleroxacin overview. Chemotherapy. 1996 Mar;42 Suppl 1:1-9. DMXGQYZ RU https://pubmed.ncbi.nlm.nih.gov/8861529 DM70DTN DI DM70DTN DM70DTN DN Flibanserin DM70DTN MI TTSQIFT DM70DTN MN 5-HT 1A receptor (HTR1A) DM70DTN MT DTT DM70DTN MA Modulator DM70DTN RN Radium 223 dichloride for prostate cancer treatment. Drug Des Devel Ther. 2017 Sep 6;11:2643-2651. DM70DTN RU https://pubmed.ncbi.nlm.nih.gov/28919714 DM70DTN DI DM70DTN DM70DTN DN Flibanserin DM70DTN MI TTJQOD7 DM70DTN MN 5-HT 2A receptor (HTR2A) DM70DTN MT DTT DM70DTN MA Modulator DM70DTN RN Radium 223 dichloride for prostate cancer treatment. Drug Des Devel Ther. 2017 Sep 6;11:2643-2651. DM70DTN RU https://pubmed.ncbi.nlm.nih.gov/28919714 DM70DTN DI DM70DTN DM70DTN DN Flibanserin DM70DTN MI DE4LYSA DM70DTN MN Cytochrome P450 3A4 (CYP3A4) DM70DTN MT DME DM70DTN MA Metabolism DM70DTN RN Flibanserin: first global approval. Drugs. 2015 Oct;75(15):1815-22. DM70DTN RU https://www.ncbi.nlm.nih.gov/pubmed/?term=26412054 DM70DTN DI DM70DTN DM70DTN DN Flibanserin DM70DTN MI DEGTFWK DM70DTN MN Mephenytoin 4-hydroxylase (CYP2C19) DM70DTN MT DME DM70DTN MA Metabolism DM70DTN RN Flibanserin therapy and CYP2C19 genotype. DM70DTN RU https://www.ncbi.nlm.nih.gov/pubmed/?term=31550099 DMJ8A3Z DI DMJ8A3Z DMJ8A3Z DN Florbetapir F-18 DMJ8A3Z MI TTE4KHA DMJ8A3Z MN Amyloid beta A4 protein (APP) DMJ8A3Z MT DTT DMJ8A3Z MA Modulator DMJ8A3Z RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015 DMJ8A3Z RU https://www.accessdata.fda.gov/scripts/cder/drugsatfda/ DM04LR2 DI DM04LR2 DM04LR2 DN Floxuridine DM04LR2 MI TTU6BFZ DM04LR2 MN Candida Thymidylate synthase (Candi TMP1) DM04LR2 MT DTT DM04LR2 MA Inhibitor DM04LR2 RN Antisense down-regulation of thymidylate synthase to suppress growth and enhance cytotoxicity of 5-FUdR, 5-FU and Tomudex in HeLa cells. Br J Pharmacol. 1999 Aug;127(8):1777-86. DM04LR2 RU https://pubmed.ncbi.nlm.nih.gov/10482907 DM04LR2 DI DM04LR2 DM04LR2 DN Floxuridine DM04LR2 MI DE4HCYL DM04LR2 MN Thymidine phosphorylase (TYMP) DM04LR2 MT DME DM04LR2 MA Metabolism DM04LR2 RN Enhanced cancer cell growth inhibition by dipeptide prodrugs of floxuridine: increased transporter affinity and metabolic stability. Mol Pharm. 2008 Sep-Oct;5(5):717-27. DM04LR2 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=18652477 DMNUWST DI DMNUWST DMNUWST DN Flucloxacillin DMNUWST MI TTJP4SM DMNUWST MN Bacterial Penicillin binding protein (Bact PBP) DMNUWST MT DTT DMNUWST MA Binder DMNUWST RN Mechanisms of resistance to beta-lactam antibiotics in Staphylococcus aureus. Scand J Infect Dis Suppl. 1984;42:64-71. DMNUWST RU https://pubmed.ncbi.nlm.nih.gov/6335600 DMNUWST DI DMNUWST DMNUWST DN Flucloxacillin DMNUWST MI DE4LYSA DMNUWST MN Cytochrome P450 3A4 (CYP3A4) DMNUWST MT DME DMNUWST MA Metabolism DMNUWST RN Characterization of kinetics of human cytochrome P450s involved in bioactivation of flucloxacillin: inhibition of CYP3A-catalysed hydroxylation by sulfaphenazole. Br J Pharmacol. 2019 Feb;176(3):466-477. DMNUWST RU https://www.ncbi.nlm.nih.gov/pubmed/?term=30447161 DMNUWST DI DMNUWST DMNUWST DN Flucloxacillin DMNUWST MI DT9G7XN DMNUWST MN Peptide transporter 1 (SLC15A1) DMNUWST MT DTP DMNUWST MA Substrate DMNUWST RN Three-dimensional quantitative structure-activity relationship analyses of beta-lactam antibiotics and tripeptides as substrates of the mammalian H+/peptide cotransporter PEPT1. J Med Chem. 2005 Jun 30;48(13):4410-9. DMNUWST RU http://www.ncbi.nlm.nih.gov/pubmed/15974593 DMOWZ6B DI DMOWZ6B DMOWZ6B DN Fluconazole DMOWZ6B MI TTTSOUD DMOWZ6B MN Candida Cytochrome P450 51 (Candi ERG11) DMOWZ6B MT DTT DMOWZ6B MA Modulator DMOWZ6B RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. DMOWZ6B RU https://www.fda.gov/ DMOWZ6B DI DMOWZ6B DMOWZ6B DN Fluconazole DMOWZ6B MI DE5IED8 DMOWZ6B MN Cytochrome P450 2C9 (CYP2C9) DMOWZ6B MT DME DMOWZ6B MA Metabolism DMOWZ6B RN Effect of fluconazole on plasma fluvastatin and pravastatin concentrations. Eur J Clin Pharmacol. 2000 Jun;56(3):225-9. DMOWZ6B RU https://www.ncbi.nlm.nih.gov/pubmed/?term=10952477 DM13VTW DI DM13VTW DM13VTW DN Flucytosine DM13VTW MI TTU6BFZ DM13VTW MN Candida Thymidylate synthase (Candi TMP1) DM13VTW MT DTT DM13VTW MA Inhibitor DM13VTW RN Antifungal agents: mode of action in yeast cells. Rev Esp Quimioter. 2006 Jun;19(2):130-9. DM13VTW RU https://pubmed.ncbi.nlm.nih.gov/16964330 DMVRLT7 DI DMVRLT7 DMVRLT7 DN Fludarabine DMVRLT7 MI TTLP57V DMVRLT7 MN Adenosine deaminase (ADA) DMVRLT7 MT DTT DMVRLT7 MA Inhibitor DMVRLT7 RN Purine nucleoside analogs in indolent non-Hodgkin's lymphoma. Oncology (Williston Park). 2000 Jun;14(6 Suppl 2):13-5. DMVRLT7 RU https://pubmed.ncbi.nlm.nih.gov/10887639 DMD2K4I DI DMD2K4I DMD2K4I DN Fludiazepam DMD2K4I MI TTPTXIN DMD2K4I MN Translocator protein (TSPO) DMD2K4I MT DTT DMD2K4I MA Agonist DMD2K4I RN Benzodiazepines and their metabolites: relationship between binding affinity to the benzodiazepine receptor and pharmacological activity. Life Sci. 1985 Jan 14;36(2):113-9. DMD2K4I RU https://pubmed.ncbi.nlm.nih.gov/2857046 DMUDIR8 DI DMUDIR8 DMUDIR8 DN Fludrocortisone DMUDIR8 MI TTS64P2 DMUDIR8 MN Androgen receptor (AR) DMUDIR8 MT DTT DMUDIR8 MA Inhibitor DMUDIR8 RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DMUDIR8 RU https://pubmed.ncbi.nlm.nih.gov/10592235 DMUDIR8 DI DMUDIR8 DMUDIR8 DN Fludrocortisone DMUDIR8 MI DE4LYSA DMUDIR8 MN Cytochrome P450 3A4 (CYP3A4) DMUDIR8 MT DME DMUDIR8 MA Metabolism DMUDIR8 RN Summary of information on human CYP enzymes: human P450 metabolism data. Drug Metab Rev. 2002 Feb-May;34(1-2):83-448. DMUDIR8 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=11996015 DMUDIR8 DI DMUDIR8 DMUDIR8 DN Fludrocortisone DMUDIR8 MI TT26PHO DMUDIR8 MN Mineralocorticoid receptor (MR) DMUDIR8 MT DTT DMUDIR8 MA Agonist DMUDIR8 RN Mineralocorticoid receptor-mediated inhibition of the hypothalamic-pituitary-adrenal axis in aged humans. J Gerontol A Biol Sci Med Sci. 2003 Oct;58(10):B900-5. DMUDIR8 RU https://pubmed.ncbi.nlm.nih.gov/14570856 DMC8VNH DI DMC8VNH DMC8VNH DN Flufenamic Acid DMC8VNH MI TTS64P2 DMC8VNH MN Androgen receptor (AR) DMC8VNH MT DTT DMC8VNH MA Inhibitor DMC8VNH RN Ouellet M, Percival MD: Effect of inhibitor time-dependency on selectivity towards cyclooxygenase isoforms. Biochem J. 1995 Feb 15;306 ( Pt 1):247-51. DMC8VNH RU https://pubmed.ncbi.nlm.nih.gov/7864817 DMC8VNH DI DMC8VNH DMC8VNH DN Flufenamic Acid DMC8VNH MI TT5ZWB6 DMC8VNH MN Dihydrodiol dehydrogenase type I (AKR1C3) DMC8VNH MT DTT DMC8VNH MA Inhibitor DMC8VNH RN Ouellet M, Percival MD: Effect of inhibitor time-dependency on selectivity towards cyclooxygenase isoforms. Biochem J. 1995 Feb 15;306 ( Pt 1):247-51. DMC8VNH RU https://pubmed.ncbi.nlm.nih.gov/7864817 DMC8VNH DI DMC8VNH DMC8VNH DN Flufenamic Acid DMC8VNH MI TT8NGED DMC8VNH MN Prostaglandin G/H synthase 1 (COX-1) DMC8VNH MT DTT DMC8VNH MA Inhibitor DMC8VNH RN Ouellet M, Percival MD: Effect of inhibitor time-dependency on selectivity towards cyclooxygenase isoforms. Biochem J. 1995 Feb 15;306 ( Pt 1):247-51. DMC8VNH RU https://pubmed.ncbi.nlm.nih.gov/7864817 DMC8VNH DI DMC8VNH DMC8VNH DN Flufenamic Acid DMC8VNH MI TTVKILB DMC8VNH MN Prostaglandin G/H synthase 2 (COX-2) DMC8VNH MT DTT DMC8VNH MA Inhibitor DMC8VNH RN Ouellet M, Percival MD: Effect of inhibitor time-dependency on selectivity towards cyclooxygenase isoforms. Biochem J. 1995 Feb 15;306 ( Pt 1):247-51. DMC8VNH RU https://pubmed.ncbi.nlm.nih.gov/7864817 DMPCG2L DI DMPCG2L DMPCG2L DN Flumazenil DMPCG2L MI TTBMV1G DMPCG2L MN GABA(A) receptor alpha-2 (GABRA2) DMPCG2L MT DTT DMPCG2L MA Modulator (allosteric modulator) DMPCG2L RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 405). DMPCG2L RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=405 DMPCG2L DI DMPCG2L DMPCG2L DN Flumazenil DMPCG2L MI TT37EDJ DMPCG2L MN GABA(A) receptor alpha-3 (GABRA3) DMPCG2L MT DTT DMPCG2L MA Modulator (allosteric modulator) DMPCG2L RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 406). DMPCG2L RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=406 DMPCG2L DI DMPCG2L DMPCG2L DN Flumazenil DMPCG2L MI TTNZPQ1 DMPCG2L MN GABA(A) receptor alpha-5 (GABRA5) DMPCG2L MT DTT DMPCG2L MA Modulator (allosteric modulator) DMPCG2L RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 408). DMPCG2L RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=408 DMPCG2L DI DMPCG2L DMPCG2L DN Flumazenil DMPCG2L MI TTEX6LM DMPCG2L MN GABA(A) receptor gamma-3 (GABRG3) DMPCG2L MT DTT DMPCG2L MA Modulator (allosteric modulator) DMPCG2L RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 415). DMPCG2L RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=415 DMPCG2L DI DMPCG2L DMPCG2L DN Flumazenil DMPCG2L MI TTPTXIN DMPCG2L MN Translocator protein (TSPO) DMPCG2L MT DTT DMPCG2L MA Antagonist DMPCG2L RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2879). DMPCG2L RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2879 DMUNG4A DI DMUNG4A DMUNG4A DN Flumethasone DMUNG4A MI DE4LYSA DMUNG4A MN Cytochrome P450 3A4 (CYP3A4) DMUNG4A MT DME DMUNG4A MA Metabolism DMUNG4A RN Prediction of cytochrome P450 isoform responsible for metabolizing a drug molecule. BMC Pharmacol. 2010 Jul 16;10:8. DMUNG4A RU https://www.ncbi.nlm.nih.gov/pubmed/?term=20637097 DMU0YP6 DI DMU0YP6 DMU0YP6 DN Flumethasone Pivalate DMU0YP6 MI TTP3UTW DMU0YP6 MN Steroid hormone receptor ERR (ESRR) DMU0YP6 MT DTT DMU0YP6 MA Modulator DMU0YP6 RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. DMU0YP6 RU https://www.fda.gov/ DMZU5JP DI DMZU5JP DMZU5JP DN Flunarizine DMZU5JP MI DE6OQ3W DMZU5JP MN Cytochrome P450 1A1 (CYP1A1) DMZU5JP MT DME DMZU5JP MA Metabolism DMZU5JP RN Oxidative metabolism of flunarizine and cinnarizine by microsomes from B-lymphoblastoid cell lines expressing human cytochrome P450 enzymes. Biol Pharm Bull. 1996 Nov;19(11):1511-4. DMZU5JP RU https://www.ncbi.nlm.nih.gov/pubmed/?term=8951176 DMZU5JP DI DMZU5JP DMZU5JP DN Flunarizine DMZU5JP MI DEJGDUW DMZU5JP MN Cytochrome P450 1A2 (CYP1A2) DMZU5JP MT DME DMZU5JP MA Metabolism DMZU5JP RN Oxidative metabolism of flunarizine and cinnarizine by microsomes from B-lymphoblastoid cell lines expressing human cytochrome P450 enzymes. Biol Pharm Bull. 1996 Nov;19(11):1511-4. DMZU5JP RU https://www.ncbi.nlm.nih.gov/pubmed/?term=8951176 DMZU5JP DI DMZU5JP DMZU5JP DN Flunarizine DMZU5JP MI DEJVYAZ DMZU5JP MN Cytochrome P450 2A6 (CYP2A6) DMZU5JP MT DME DMZU5JP MA Metabolism DMZU5JP RN Oxidative metabolism of flunarizine and cinnarizine by microsomes from B-lymphoblastoid cell lines expressing human cytochrome P450 enzymes. Biol Pharm Bull. 1996 Nov;19(11):1511-4. DMZU5JP RU https://www.ncbi.nlm.nih.gov/pubmed/?term=8951176 DMZU5JP DI DMZU5JP DMZU5JP DN Flunarizine DMZU5JP MI DE5IED8 DMZU5JP MN Cytochrome P450 2C9 (CYP2C9) DMZU5JP MT DME DMZU5JP MA Metabolism DMZU5JP RN Oxidative metabolism of flunarizine and cinnarizine by microsomes from B-lymphoblastoid cell lines expressing human cytochrome P450 enzymes. Biol Pharm Bull. 1996 Nov;19(11):1511-4. DMZU5JP RU https://www.ncbi.nlm.nih.gov/pubmed/?term=8951176 DMZU5JP DI DMZU5JP DMZU5JP DN Flunarizine DMZU5JP MI DECB0K3 DMZU5JP MN Cytochrome P450 2D6 (CYP2D6) DMZU5JP MT DME DMZU5JP MA Metabolism DMZU5JP RN Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. DMZU5JP RU https://www.ncbi.nlm.nih.gov/pubmed/?term=19515014 DMZU5JP DI DMZU5JP DMZU5JP DN Flunarizine DMZU5JP MI TTX4QDJ DMZU5JP MN Voltage-gated calcium channel alpha Cav2.1 (CACNA1A) DMZU5JP MT DTT DMZU5JP MA Inhibitor DMZU5JP RN Antibodies and venom peptides: new modalities for ion channels. Nat Rev Drug Discov. 2019 May;18(5):339-357. DMZU5JP RU https://pubmed.ncbi.nlm.nih.gov/30728472 DMZU5JP DI DMZU5JP DMZU5JP DN Flunarizine DMZU5JP MI TTZPWGN DMZU5JP MN Voltage-gated calcium channel alpha Cav3.2 (CACNA1H) DMZU5JP MT DTT DMZU5JP MA Blocker DMZU5JP RN Positive allosteric interaction of structurally diverse T-type calcium channel antagonists. Cell Biochem Biophys. 2009;55(2):81-93. DMZU5JP RU https://pubmed.ncbi.nlm.nih.gov/19582593 DMZSWQC DI DMZSWQC DMZSWQC DN Flunisolide DMZSWQC MI DE4LYSA DMZSWQC MN Cytochrome P450 3A4 (CYP3A4) DMZSWQC MT DME DMZSWQC MA Metabolism DMZSWQC RN Metabolic pathways of inhaled glucocorticoids by the CYP3A enzymes. Drug Metab Dispos. 2013 Feb;41(2):379-89. DMZSWQC RU https://www.ncbi.nlm.nih.gov/pubmed/?term=23143891 DMZSWQC DI DMZSWQC DMZSWQC DN Flunisolide DMZSWQC MI TTYRL6O DMZSWQC MN Glucocorticoid receptor (NR3C1) DMZSWQC MT DTT DMZSWQC MA Agonist DMZSWQC RN The glucocorticoid receptor heterocomplex gene STIP1 is associated with improved lung function in asthmatic subjects treated with inhaled corticost... J Allergy Clin Immunol. 2009 Jun;123(6):1376-83.e7. DMZSWQC RU https://pubmed.ncbi.nlm.nih.gov/19254810 DMGR5Z3 DI DMGR5Z3 DMGR5Z3 DN Flunitrazepam DMGR5Z3 MI DEJGDUW DMGR5Z3 MN Cytochrome P450 1A2 (CYP1A2) DMGR5Z3 MT DME DMGR5Z3 MA Metabolism DMGR5Z3 RN Summary of information on human CYP enzymes: human P450 metabolism data. Drug Metab Rev. 2002 Feb-May;34(1-2):83-448. DMGR5Z3 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=11996015 DMGR5Z3 DI DMGR5Z3 DMGR5Z3 DN Flunitrazepam DMGR5Z3 MI DEJVYAZ DMGR5Z3 MN Cytochrome P450 2A6 (CYP2A6) DMGR5Z3 MT DME DMGR5Z3 MA Metabolism DMGR5Z3 RN CYP3A4 is the major CYP isoform mediating the in vitro hydroxylation and demethylation of flunitrazepam. Drug Metab Dispos. 2001 Feb;29(2):133-40. DMGR5Z3 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=11159802 DMGR5Z3 DI DMGR5Z3 DMGR5Z3 DN Flunitrazepam DMGR5Z3 MI DEPKLMQ DMGR5Z3 MN Cytochrome P450 2B6 (CYP2B6) DMGR5Z3 MT DME DMGR5Z3 MA Metabolism DMGR5Z3 RN CYP3A4 is the major CYP isoform mediating the in vitro hydroxylation and demethylation of flunitrazepam. Drug Metab Dispos. 2001 Feb;29(2):133-40. DMGR5Z3 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=11159802 DMGR5Z3 DI DMGR5Z3 DMGR5Z3 DN Flunitrazepam DMGR5Z3 MI DE5IED8 DMGR5Z3 MN Cytochrome P450 2C9 (CYP2C9) DMGR5Z3 MT DME DMGR5Z3 MA Metabolism DMGR5Z3 RN CYP3A4 is the major CYP isoform mediating the in vitro hydroxylation and demethylation of flunitrazepam. Drug Metab Dispos. 2001 Feb;29(2):133-40. DMGR5Z3 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=11159802 DMGR5Z3 DI DMGR5Z3 DMGR5Z3 DN Flunitrazepam DMGR5Z3 MI DE4LYSA DMGR5Z3 MN Cytochrome P450 3A4 (CYP3A4) DMGR5Z3 MT DME DMGR5Z3 MA Metabolism DMGR5Z3 RN Cytochrome P450 3A4 and benzodiazepines. Seishin Shinkeigaku Zasshi. 2003;105(5):631-42. DMGR5Z3 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=12875231 DMGR5Z3 DI DMGR5Z3 DMGR5Z3 DN Flunitrazepam DMGR5Z3 MI DEGTFWK DMGR5Z3 MN Mephenytoin 4-hydroxylase (CYP2C19) DMGR5Z3 MT DME DMGR5Z3 MA Metabolism DMGR5Z3 RN The role of cytochrome P450 2C19 activity in flunitrazepam metabolism in vivo. J Clin Psychopharmacol. 2003 Apr;23(2):169-75. DMGR5Z3 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=12640218 DMGR5Z3 DI DMGR5Z3 DMGR5Z3 DN Flunitrazepam DMGR5Z3 MI DE0QLUZ DMGR5Z3 MN Oxygen-insensitive NADPH nitroreductase B (nfsB) DMGR5Z3 MT DME DMGR5Z3 MA Metabolism DMGR5Z3 RN Structure-based development of bacterial nitroreductase against nitrobenzodiazepine-induced hypnosis. Biochem Pharmacol. 2012 Jun 15;83(12):1690-9. DMGR5Z3 RU https://pubmed.ncbi.nlm.nih.gov/22445794 DMGR5Z3 DI DMGR5Z3 DMGR5Z3 DN Flunitrazepam DMGR5Z3 MI TTPTXIN DMGR5Z3 MN Translocator protein (TSPO) DMGR5Z3 MT DTT DMGR5Z3 MA Agonist DMGR5Z3 RN Comparison of five benzodiazepine-receptor agonists on buprenorphine-induced mu-opioid receptor regulation. J Pharmacol Sci. 2009 May;110(1):36-46. DMGR5Z3 RU https://pubmed.ncbi.nlm.nih.gov/19443999 DMG2KI4 DI DMG2KI4 DMG2KI4 DN Fluocinolone acetonide DMG2KI4 MI DE4LYSA DMG2KI4 MN Cytochrome P450 3A4 (CYP3A4) DMG2KI4 MT DME DMG2KI4 MA Metabolism DMG2KI4 RN Metabolic pathways of inhaled glucocorticoids by the CYP3A enzymes. Drug Metab Dispos. 2013 Feb;41(2):379-89. DMG2KI4 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=23143891 DMG2KI4 DI DMG2KI4 DMG2KI4 DN Fluocinolone acetonide DMG2KI4 MI TTYRL6O DMG2KI4 MN Glucocorticoid receptor (NR3C1) DMG2KI4 MT DTT DMG2KI4 MA Modulator DMG2KI4 RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. DMG2KI4 RU https://www.fda.gov/ DM65KL8 DI DM65KL8 DM65KL8 DN Fluocinonide DM65KL8 MI DE4LYSA DM65KL8 MN Cytochrome P450 3A4 (CYP3A4) DM65KL8 MT DME DM65KL8 MA Metabolism DM65KL8 RN Metabolic pathways of inhaled glucocorticoids by the CYP3A enzymes. Drug Metab Dispos. 2013 Feb;41(2):379-89. DM65KL8 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=23143891 DM65KL8 DI DM65KL8 DM65KL8 DN Fluocinonide DM65KL8 MI TTP3UTW DM65KL8 MN Steroid hormone receptor ERR (ESRR) DM65KL8 MT DTT DM65KL8 MA Modulator DM65KL8 RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. DM65KL8 RU https://www.fda.gov/ DMQTFAO DI DMQTFAO DMQTFAO DN Fluorescein DMQTFAO MI TTHQZV7 DMQTFAO MN Mothers against decapentaplegic homolog 3 (SMAD3) DMQTFAO MT DTT DMQTFAO MA Inhibitor DMQTFAO RN In silico identification and biochemical evaluation of novel inhibitors of NRH:quinone oxidoreductase 2 (NQO2). Bioorg Med Chem Lett. 2010 Dec 15;20(24):7331-6. DMQTFAO RU https://pubmed.ncbi.nlm.nih.gov/21074425 DMQTFAO DI DMQTFAO DMQTFAO DN Fluorescein DMQTFAO MI DTSYQGK DMQTFAO MN Multidrug resistance-associated protein 1 (ABCC1) DMQTFAO MT DTP DMQTFAO MA Substrate DMQTFAO RN Transport of fluorescein in MDCKII-MRP1 transfected cells and mrp1-knockout mice. Biochem Biophys Res Commun. 2001 Jun 22;284(4):863-9. DMQTFAO RU http://www.ncbi.nlm.nih.gov/pubmed/11409873 DMQTFAO DI DMQTFAO DMQTFAO DN Fluorescein DMQTFAO MI DTFI42L DMQTFAO MN Multidrug resistance-associated protein 2 (ABCC2) DMQTFAO MT DTP DMQTFAO MA Substrate DMQTFAO RN Phosphoinositide 3-kinase/protein kinase B signaling pathway is involved in estradiol 17-D-glucuronide-induced cholestasis: complementarity with classical protein kinase C. Hepatology. 2010 Oct;52(4):1465-76. DMQTFAO RU http://www.ncbi.nlm.nih.gov/pubmed/20815017 DMQTFAO DI DMQTFAO DMQTFAO DN Fluorescein DMQTFAO MI DTYVM24 DMQTFAO MN Multidrug resistance-associated protein 5 (ABCC5) DMQTFAO MT DTP DMQTFAO MA Substrate DMQTFAO RN Hyaluronan export by the ABC transporter MRP5 and its modulation by intracellular cGMP. J Biol Chem. 2007 Jul 20;282(29):20999-1004. DMQTFAO RU http://www.ncbi.nlm.nih.gov/pubmed/17540771 DMQTFAO DI DMQTFAO DMQTFAO DN Fluorescein DMQTFAO MI DTQ23VB DMQTFAO MN Organic anion transporter 1 (SLC22A6) DMQTFAO MT DTP DMQTFAO MA Substrate DMQTFAO RN Apical expression or expression in a non polarized cell of hOAT1 inverses regulation by epidermal growth factor (EGF) as compared to basolateral hOAT1. Cell Physiol Biochem. 2004;14(3):177-86. DMQTFAO RU http://www.ncbi.nlm.nih.gov/pubmed/15107594 DMQTFAO DI DMQTFAO DMQTFAO DN Fluorescein DMQTFAO MI DT3D8F0 DMQTFAO MN Organic anion transporting polypeptide 1B1 (SLCO1B1) DMQTFAO MT DTP DMQTFAO MA Substrate DMQTFAO RN Organic Anion Transporter 2-Mediated Hepatic Uptake Contributes to the Clearance of High-Permeability-Low-Molecular-Weight Acid and Zwitterion Drugs: Evaluation Using 25 Drugs. J Pharmacol Exp Ther. 2018 Nov;367(2):322-334. DMQTFAO RU http://www.ncbi.nlm.nih.gov/pubmed/30135178 DMQTFAO DI DMQTFAO DMQTFAO DN Fluorescein DMQTFAO MI DT9C1TS DMQTFAO MN Organic anion transporting polypeptide 1B3 (SLCO1B3) DMQTFAO MT DTP DMQTFAO MA Substrate DMQTFAO RN Development of a cell-based high-throughput assay to screen for inhibitors of organic anion transporting polypeptides 1B1 and 1B3. Curr Chem Genomics. 2010 Mar 1;4:1-8. DMQTFAO RU http://www.ncbi.nlm.nih.gov/pubmed/20448812 DMQTFAO DI DMQTFAO DMQTFAO DN Fluorescein DMQTFAO MI TTTQR47 DMQTFAO MN Solute carrier family 22 member 8 (SLC22A8) DMQTFAO MT DTT DMQTFAO MA Inhibitor DMQTFAO RN Structural variation governs substrate specificity for organic anion transporter (OAT) homologs. Potential remote sensing by OAT family members. J Biol Chem. 2007 Aug 17;282(33):23841-53. DMQTFAO RU https://pubmed.ncbi.nlm.nih.gov/17553798 DM2HKC4 DI DM2HKC4 DM2HKC4 DN Fluorometholone DM2HKC4 MI DE4LYSA DM2HKC4 MN Cytochrome P450 3A4 (CYP3A4) DM2HKC4 MT DME DM2HKC4 MA Metabolism DM2HKC4 RN Regulation of drug-metabolizing cytochrome P450 enzymes by glucocorticoids. Drug Metab Rev. 2010 Nov;42(4):621-35. DM2HKC4 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=20482443 DM2HKC4 DI DM2HKC4 DM2HKC4 DN Fluorometholone DM2HKC4 MI TTYRL6O DM2HKC4 MN Glucocorticoid receptor (NR3C1) DM2HKC4 MT DTT DM2HKC4 MA Binder DM2HKC4 RN Loteprednol etabonate: a soft steroid for the treatment of allergic diseases of the airways. Drugs Today (Barc). 2000 May;36(5):313-20. DM2HKC4 RU https://pubmed.ncbi.nlm.nih.gov/12861354 DMUM7HZ DI DMUM7HZ DMUM7HZ DN Fluorouracil DMUM7HZ MI DEMJ7R2 DMUM7HZ MN Amidophosphoribosyltransferase (GPAT) DMUM7HZ MT DME DMUM7HZ MA Metabolism DMUM7HZ RN PharmGKB: A worldwide resource for pharmacogenomic information. Wiley Interdiscip Rev Syst Biol Med. 2018 Jul;10(4):e1417. (ID: PA150653776) DMUM7HZ RU https://www.pharmgkb.org/pathway/PA150653776 DMUM7HZ DI DMUM7HZ DMUM7HZ DN Fluorouracil DMUM7HZ MI DTI7UX6 DMUM7HZ MN Breast cancer resistance protein (ABCG2) DMUM7HZ MT DTP DMUM7HZ MA Substrate DMUM7HZ RN Role of BCRP as a biomarker for predicting resistance to 5-fluorouracil in breast cancer. Cancer Chemother Pharmacol. 2009 May;63(6):1103-10. DMUM7HZ RU http://www.ncbi.nlm.nih.gov/pubmed/18820913 DMUM7HZ DI DMUM7HZ DMUM7HZ DN Fluorouracil DMUM7HZ MI TTU6BFZ DMUM7HZ MN Candida Thymidylate synthase (Candi TMP1) DMUM7HZ MT DTT DMUM7HZ MA Inhibitor DMUM7HZ RN The efficacy of the combination therapy of 5-fluorouracil, cisplatin and leucovorin for hepatocellular carcinoma and its predictable factors. Cancer Chemother Pharmacol. 2004 Apr;53(4):296-304. DMUM7HZ RU https://pubmed.ncbi.nlm.nih.gov/14689231 DMUM7HZ DI DMUM7HZ DMUM7HZ DN Fluorouracil DMUM7HZ MI DEJGDUW DMUM7HZ MN Cytochrome P450 1A2 (CYP1A2) DMUM7HZ MT DME DMUM7HZ MA Metabolism DMUM7HZ RN Roles of cytochromes P450 1A2, 2A6, and 2C8 in 5-fluorouracil formation from tegafur, an anticancer prodrug, in human liver microsomes. Drug Metab Dispos. 2000 Dec;28(12):1457-63. DMUM7HZ RU https://www.ncbi.nlm.nih.gov/pubmed/?term=11095583 DMUM7HZ DI DMUM7HZ DMUM7HZ DN Fluorouracil DMUM7HZ MI DEJVYAZ DMUM7HZ MN Cytochrome P450 2A6 (CYP2A6) DMUM7HZ MT DME DMUM7HZ MA Metabolism DMUM7HZ RN Roles of cytochromes P450 1A2, 2A6, and 2C8 in 5-fluorouracil formation from tegafur, an anticancer prodrug, in human liver microsomes. Drug Metab Dispos. 2000 Dec;28(12):1457-63. DMUM7HZ RU https://www.ncbi.nlm.nih.gov/pubmed/?term=11095583 DMUM7HZ DI DMUM7HZ DMUM7HZ DN Fluorouracil DMUM7HZ MI DES5XRU DMUM7HZ MN Cytochrome P450 2C8 (CYP2C8) DMUM7HZ MT DME DMUM7HZ MA Metabolism DMUM7HZ RN Roles of cytochromes P450 1A2, 2A6, and 2C8 in 5-fluorouracil formation from tegafur, an anticancer prodrug, in human liver microsomes. Drug Metab Dispos. 2000 Dec;28(12):1457-63. DMUM7HZ RU https://www.ncbi.nlm.nih.gov/pubmed/?term=11095583 DMUM7HZ DI DMUM7HZ DMUM7HZ DN Fluorouracil DMUM7HZ MI TTZPS91 DMUM7HZ MN Dihydrothymine dehydrogenase (DPYD) DMUM7HZ MT DTT DMUM7HZ MA Inhibitor DMUM7HZ RN Enhancement of the antitumour activity of 5-fluorouracil (5-FU) by inhibiting dihydropyrimidine dehydrogenase activity (DPD) using 5-chloro-2,4-dihydroxypyridine (CDHP) in human tumour cells. Eur J Cancer. 2002 Jun;38(9):1271-7. DMUM7HZ RU https://pubmed.ncbi.nlm.nih.gov/12044515 DMUM7HZ DI DMUM7HZ DMUM7HZ DN Fluorouracil DMUM7HZ MI DESOEW1 DMUM7HZ MN Dihydrothymine dehydrogenase (DPYD) DMUM7HZ MT DME DMUM7HZ MA Metabolism DMUM7HZ RN 5-Fluorouracil toxicity-attributable IVS14 + 1G > A mutation of the dihydropyrimidine dehydrogenase gene in Polish colorectal cancer patients. Pharmacol Rep. 2008 Mar-Apr;60(2):238-42. DMUM7HZ RU https://www.ncbi.nlm.nih.gov/pubmed/?term=18443386 DMUM7HZ DI DMUM7HZ DMUM7HZ DN Fluorouracil DMUM7HZ MI DTXD1TQ DMUM7HZ MN Equilibrative nucleoside transporter 1 (SLC29A1) DMUM7HZ MT DTP DMUM7HZ MA Substrate DMUM7HZ RN Human equilibrative nucleoside transporter 1, as a predictor of 5-fluorouracil resistance in human pancreatic cancer. Anticancer Res. 2007 Jul-Aug;27(4B):2241-9. DMUM7HZ RU http://www.ncbi.nlm.nih.gov/pubmed/17695509 DMUM7HZ DI DMUM7HZ DMUM7HZ DN Fluorouracil DMUM7HZ MI DEOXTPZ DMUM7HZ MN Methylenetetrahydrofolate reductase (MTHFR) DMUM7HZ MT DME DMUM7HZ MA Metabolism DMUM7HZ RN 5-Fluorouracil pharmacogenomics: still rocking after all these years? Pharmacogenomics. 2011 Feb;12(2):251-65. DMUM7HZ RU https://www.ncbi.nlm.nih.gov/pubmed/?term=21332317 DMUM7HZ DI DMUM7HZ DMUM7HZ DN Fluorouracil DMUM7HZ MI DTFI42L DMUM7HZ MN Multidrug resistance-associated protein 2 (ABCC2) DMUM7HZ MT DTP DMUM7HZ MA Substrate DMUM7HZ RN Enhancing chemosensitivity in oral squamous cell carcinoma by lentivirus vector-mediated RNA interference targeting EGFR and MRP2. Oncol Lett. 2016 Sep;12(3):2107-2114. DMUM7HZ RU http://www.ncbi.nlm.nih.gov/pubmed/27602148 DMUM7HZ DI DMUM7HZ DMUM7HZ DN Fluorouracil DMUM7HZ MI DTQ3ZHF DMUM7HZ MN Multidrug resistance-associated protein 3 (ABCC3) DMUM7HZ MT DTP DMUM7HZ MA Substrate DMUM7HZ RN ATP-binding cassette C transporters in human pancreatic carcinoma cell lines. Upregulation in 5-fluorouracil-resistant cells. Pancreatology. 2009;9(1-2):136-44. DMUM7HZ RU http://www.ncbi.nlm.nih.gov/pubmed/19077464 DMUM7HZ DI DMUM7HZ DMUM7HZ DN Fluorouracil DMUM7HZ MI DTCSGPB DMUM7HZ MN Multidrug resistance-associated protein 4 (ABCC4) DMUM7HZ MT DTP DMUM7HZ MA Substrate DMUM7HZ RN ATP-binding cassette C transporters in human pancreatic carcinoma cell lines. Upregulation in 5-fluorouracil-resistant cells. Pancreatology. 2009;9(1-2):136-44. DMUM7HZ RU http://www.ncbi.nlm.nih.gov/pubmed/19077464 DMUM7HZ DI DMUM7HZ DMUM7HZ DN Fluorouracil DMUM7HZ MI DTYVM24 DMUM7HZ MN Multidrug resistance-associated protein 5 (ABCC5) DMUM7HZ MT DTP DMUM7HZ MA Substrate DMUM7HZ RN ATP-binding cassette C transporters in human pancreatic carcinoma cell lines. Upregulation in 5-fluorouracil-resistant cells. Pancreatology. 2009;9(1-2):136-44. DMUM7HZ RU http://www.ncbi.nlm.nih.gov/pubmed/19077464 DMUM7HZ DI DMUM7HZ DMUM7HZ DN Fluorouracil DMUM7HZ MI DT0OC1Q DMUM7HZ MN Organic anion transporter 2 (SLC22A7) DMUM7HZ MT DTP DMUM7HZ MA Substrate DMUM7HZ RN Transport mechanism and substrate specificity of human organic anion transporter 2 (hOat2 [SLC22A7]). J Pharm Pharmacol. 2005 May;57(5):573-8. DMUM7HZ RU http://www.ncbi.nlm.nih.gov/pubmed/15901346 DMUM7HZ DI DMUM7HZ DMUM7HZ DN Fluorouracil DMUM7HZ MI DTUGYRD DMUM7HZ MN P-glycoprotein 1 (ABCB1) DMUM7HZ MT DTP DMUM7HZ MA Substrate DMUM7HZ RN Mammalian drug efflux transporters of the ATP binding cassette (ABC) family in multidrug resistance: A review of the past decade. Cancer Lett. 2016 Jan 1;370(1):153-64. DMUM7HZ RU http://www.ncbi.nlm.nih.gov/pubmed/26499806 DMUM7HZ DI DMUM7HZ DMUM7HZ DN Fluorouracil DMUM7HZ MI TTQY2EJ DMUM7HZ MN TERT messenger RNA (TERT mRNA) DMUM7HZ MT DTT DMUM7HZ RN Design and development of antisense drugs. Expert Opin. Drug Discov. 2008 3(10):1189-1207. DMUM7HZ RU http://www.informahealthcare.com/doi/abs/10.1517/17460441.3.10.1177 DMUM7HZ DI DMUM7HZ DMUM7HZ DN Fluorouracil DMUM7HZ MI DE4HCYL DMUM7HZ MN Thymidine phosphorylase (TYMP) DMUM7HZ MT DME DMUM7HZ MA Metabolism DMUM7HZ RN 5-Fluorouracil pharmacogenomics: still rocking after all these years? Pharmacogenomics. 2011 Feb;12(2):251-65. DMUM7HZ RU https://www.ncbi.nlm.nih.gov/pubmed/?term=21332317 DMUM7HZ DI DMUM7HZ DMUM7HZ DN Fluorouracil DMUM7HZ MI DEASG0Q DMUM7HZ MN Thymidylate synthase (TYMS) DMUM7HZ MT DME DMUM7HZ MA Metabolism DMUM7HZ RN 5-Fluorouracil pharmacogenomics: still rocking after all these years? Pharmacogenomics. 2011 Feb;12(2):251-65. DMUM7HZ RU https://www.ncbi.nlm.nih.gov/pubmed/?term=21332317 DMUM7HZ DI DMUM7HZ DMUM7HZ DN Fluorouracil DMUM7HZ MI TTP1UKZ DMUM7HZ MN Thymidylate synthase messenger RNA (TYMS mRNA) DMUM7HZ MT DTT DMUM7HZ RN Design and development of antisense drugs. Expert Opin. Drug Discov. 2008 3(10):1189-1207. DMUM7HZ RU http://www.informahealthcare.com/doi/abs/10.1517/17460441.3.10.1177 DMUM7HZ DI DMUM7HZ DMUM7HZ DN Fluorouracil DMUM7HZ MI DE20ETR DMUM7HZ MN Uracil phosphoribosyltransferase (UPRT) DMUM7HZ MT DME DMUM7HZ MA Metabolism DMUM7HZ RN Combined suicide gene therapy for human colon cancer cells using adenovirus-mediated transfer of escherichia coli cytosine deaminase gene and Escherichia coli uracil phosphoribosyltransferase gene with 5-fluorocytosine. Cancer Gene Ther. 2000 Jul;7(7):1015-22. DMUM7HZ RU https://www.ncbi.nlm.nih.gov/pubmed/?term=10917204 DMUM7HZ DI DMUM7HZ DMUM7HZ DN Fluorouracil DMUM7HZ MI DEWJYTE DMUM7HZ MN Uridine 5'-monophosphate synthase (UMPS) DMUM7HZ MT DME DMUM7HZ MA Metabolism DMUM7HZ RN Orotate phosphoribosyltransferase is overexpressed in malignant pleural mesothelioma: Dramatically responds one case in high OPRT expression. Rare Dis. 2016 Apr 5;4(1):e1165909. DMUM7HZ RU https://www.ncbi.nlm.nih.gov/pubmed/?term=27274438 DMUM7HZ DI DMUM7HZ DMUM7HZ DN Fluorouracil DMUM7HZ MI DEFZWAX DMUM7HZ MN Uridine phosphorylase 1 (UPP1) DMUM7HZ MT DME DMUM7HZ MA Metabolism DMUM7HZ RN Uridine phosphorylase in breast cancer: a new prognostic factor? Front Biosci. 2006 Sep 1;11:2759-66. DMUM7HZ RU https://www.ncbi.nlm.nih.gov/pubmed/?term=16720348 DMUM7HZ DI DMUM7HZ DMUM7HZ DN Fluorouracil DMUM7HZ MI DEBQ2WU DMUM7HZ MN Uridine phosphorylase 2 (UPP2) DMUM7HZ MT DME DMUM7HZ MA Metabolism DMUM7HZ RN Uridine phosphorylase in breast cancer: a new prognostic factor? Front Biosci. 2006 Sep 1;11:2759-66. DMUM7HZ RU https://www.ncbi.nlm.nih.gov/pubmed/?term=16720348 DM3PD2C DI DM3PD2C DM3PD2C DN Fluoxetine DM3PD2C MI DEJGDUW DM3PD2C MN Cytochrome P450 1A2 (CYP1A2) DM3PD2C MT DME DM3PD2C MA Metabolism DM3PD2C RN Clinically significant psychotropic drug-drug interactions in the primary care setting. Curr Psychiatry Rep. 2012 Aug;14(4):376-90. DM3PD2C RU https://www.ncbi.nlm.nih.gov/pubmed/?term=22707017 DM3PD2C DI DM3PD2C DM3PD2C DN Fluoxetine DM3PD2C MI DEPKLMQ DM3PD2C MN Cytochrome P450 2B6 (CYP2B6) DM3PD2C MT DME DM3PD2C MA Metabolism DM3PD2C RN Molecular characterization of CYP2B6 substrates. Curr Drug Metab. 2008 Jun;9(5):363-73. DM3PD2C RU https://www.ncbi.nlm.nih.gov/pubmed/?term=18537573 DM3PD2C DI DM3PD2C DM3PD2C DN Fluoxetine DM3PD2C MI DE5IED8 DM3PD2C MN Cytochrome P450 2C9 (CYP2C9) DM3PD2C MT DME DM3PD2C MA Metabolism DM3PD2C RN Binding of CYP2C9 with diverse drugs and its implications for metabolic mechanism. Med Chem. 2009 May;5(3):263-70. DM3PD2C RU https://www.ncbi.nlm.nih.gov/pubmed/?term=19442216 DM3PD2C DI DM3PD2C DM3PD2C DN Fluoxetine DM3PD2C MI DECB0K3 DM3PD2C MN Cytochrome P450 2D6 (CYP2D6) DM3PD2C MT DME DM3PD2C MA Metabolism DM3PD2C RN (R)-, (S)-, and racemic fluoxetine N-demethylation by human cytochrome P450 enzymes. Drug Metab Dispos. 2000 Oct;28(10):1187-91. DM3PD2C RU https://www.ncbi.nlm.nih.gov/pubmed/?term=10997938 DM3PD2C DI DM3PD2C DM3PD2C DN Fluoxetine DM3PD2C MI DEVDYN7 DM3PD2C MN Cytochrome P450 2E1 (CYP2E1) DM3PD2C MT DME DM3PD2C MA Metabolism DM3PD2C RN Antidepressant drugs in the elderly--role of the cytochrome P450 2D6. World J Biol Psychiatry. 2003 Apr;4(2):74-80. DM3PD2C RU https://www.ncbi.nlm.nih.gov/pubmed/?term=12692778 DM3PD2C DI DM3PD2C DM3PD2C DN Fluoxetine DM3PD2C MI DE4LYSA DM3PD2C MN Cytochrome P450 3A4 (CYP3A4) DM3PD2C MT DME DM3PD2C MA Metabolism DM3PD2C RN O-Dealkylation of fluoxetine in relation to CYP2C19 gene dose and involvement of CYP3A4 in human liver microsomes. J Pharmacol Exp Ther. 2002 Jan;300(1):105-11. DM3PD2C RU https://www.ncbi.nlm.nih.gov/pubmed/?term=11752104 DM3PD2C DI DM3PD2C DM3PD2C DN Fluoxetine DM3PD2C MI DEIBDNY DM3PD2C MN Cytochrome P450 3A5 (CYP3A5) DM3PD2C MT DME DM3PD2C MA Metabolism DM3PD2C RN (R)-, (S)-, and racemic fluoxetine N-demethylation by human cytochrome P450 enzymes. Drug Metab Dispos. 2000 Oct;28(10):1187-91. DM3PD2C RU https://www.ncbi.nlm.nih.gov/pubmed/?term=10997938 DM3PD2C DI DM3PD2C DM3PD2C DN Fluoxetine DM3PD2C MI DEGTFWK DM3PD2C MN Mephenytoin 4-hydroxylase (CYP2C19) DM3PD2C MT DME DM3PD2C MA Metabolism DM3PD2C RN Effects of CYP2C19 genotype and CYP2C9 on fluoxetine N-demethylation in human liver microsomes. Acta Pharmacol Sin. 2001 Jan;22(1):85-90. DM3PD2C RU https://www.ncbi.nlm.nih.gov/pubmed/?term=11730569 DM3PD2C DI DM3PD2C DM3PD2C DN Fluoxetine DM3PD2C MI DTUGYRD DM3PD2C MN P-glycoprotein 1 (ABCB1) DM3PD2C MT DTP DM3PD2C MA Substrate DM3PD2C RN Fluoxetine and reversal of multidrug resistance. Cancer Lett. 2006 Jun 18;237(2):180-7. DM3PD2C RU https://doi.org/10.1016/j.canlet.2005.06.003 DM3PD2C DI DM3PD2C DM3PD2C DN Fluoxetine DM3PD2C MI TT3ROYC DM3PD2C MN Serotonin transporter (SERT) DM3PD2C MT DTT DM3PD2C MA Modulator DM3PD2C RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. DM3PD2C RU https://www.fda.gov/ DMUHCF1 DI DMUHCF1 DMUHCF1 DN Fluoxymesterone DMUHCF1 MI TTS64P2 DMUHCF1 MN Androgen receptor (AR) DMUHCF1 MT DTT DMUHCF1 MA Agonist DMUHCF1 RN An orally active selective androgen receptor modulator is efficacious on bone, muscle, and sex function with reduced impact on prostate. Endocrinology. 2007 Jan;148(1):363-73. DMUHCF1 RU https://pubmed.ncbi.nlm.nih.gov/17023534 DMUHCF1 DI DMUHCF1 DMUHCF1 DN Fluoxymesterone DMUHCF1 MI DE4LYSA DMUHCF1 MN Cytochrome P450 3A4 (CYP3A4) DMUHCF1 MT DME DMUHCF1 MA Metabolism DMUHCF1 RN Effect of dexamethasone on cytochrome P-450 mediated metabolism of 2-acetylaminofluorene in cultured rat hepatocytes. Biochem Pharmacol. 1987 Jan 15;36(2):237-43. DMUHCF1 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=2880590 DM0DJ9O DI DM0DJ9O DM0DJ9O DN Flupentixol DM0DJ9O MI DTUGYRD DM0DJ9O MN P-glycoprotein 1 (ABCB1) DM0DJ9O MT DTP DM0DJ9O MA Substrate DM0DJ9O RN Identification of P-glycoprotein substrates and inhibitors among psychoactive compounds--implications for pharmacokinetics of selected substrates. J Pharm Pharmacol. 2004 Aug;56(8):967-75. DM0DJ9O RU http://www.ncbi.nlm.nih.gov/pubmed/15285840 DMIT8LX DI DMIT8LX DMIT8LX DN Fluphenazine DMIT8LX MI TTK8CXU DMIT8LX MN 5-HT 1B receptor (HTR1B) DMIT8LX MT DTT DMIT8LX MA Modulator DMIT8LX RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. DMIT8LX RU https://www.fda.gov/ DMIT8LX DI DMIT8LX DMIT8LX DN Fluphenazine DMIT8LX MI DECB0K3 DMIT8LX MN Cytochrome P450 2D6 (CYP2D6) DMIT8LX MT DME DMIT8LX MA Metabolism DMIT8LX RN Effect of antipsychotic drugs on human liver cytochrome P-450 (CYP) isoforms in vitro: preferential inhibition of CYP2D6. Drug Metab Dispos. 1999 Sep;27(9):1078-84. DMIT8LX RU https://www.ncbi.nlm.nih.gov/pubmed/?term=10460810 DMIT8LX DI DMIT8LX DMIT8LX DN Fluphenazine DMIT8LX MI DTUGYRD DMIT8LX MN P-glycoprotein 1 (ABCB1) DMIT8LX MT DTP DMIT8LX MA Substrate DMIT8LX RN Identification of P-glycoprotein substrates and inhibitors among psychoactive compounds--implications for pharmacokinetics of selected substrates. J Pharm Pharmacol. 2004 Aug;56(8):967-75. DMIT8LX RU http://www.ncbi.nlm.nih.gov/pubmed/15285840 DMZWBKG DI DMZWBKG DMZWBKG DN Fluprednisolone DMZWBKG MI DE4LYSA DMZWBKG MN Cytochrome P450 3A4 (CYP3A4) DMZWBKG MT DME DMZWBKG MA Metabolism DMZWBKG RN NCIthesaurus: Fluprednisolone DMZWBKG RU https://ncit-stage.nci.nih.gov/ncitbrowser/pages/concept_details.jsf?dictionary=NCI_Thesaurus&version=18.06d&code=C65730&ns=ncit&type=relationship&key=null&b=1&n=0&vse=null DMHCI9S DI DMHCI9S DMHCI9S DN Flurandrenolide DMHCI9S MI DE4LYSA DMHCI9S MN Cytochrome P450 3A4 (CYP3A4) DMHCI9S MT DME DMHCI9S MA Metabolism DMHCI9S RN Prediction of cytochrome P450 isoform responsible for metabolizing a drug molecule. BMC Pharmacol. 2010 Jul 16;10:8. DMHCI9S RU https://www.ncbi.nlm.nih.gov/pubmed/?term=20637097 DMHCI9S DI DMHCI9S DMHCI9S DN Flurandrenolide DMHCI9S MI TTP3UTW DMHCI9S MN Steroid hormone receptor ERR (ESRR) DMHCI9S MT DTT DMHCI9S MA Modulator DMHCI9S RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. DMHCI9S RU https://www.fda.gov/ DMAL4G0 DI DMAL4G0 DMAL4G0 DN Flurazepam DMAL4G0 MI DEJVYAZ DMAL4G0 MN Cytochrome P450 2A6 (CYP2A6) DMAL4G0 MT DME DMAL4G0 MA Metabolism DMAL4G0 RN Is 1-aminobenzotriazole an appropriate in vitro tool as a nonspecific cytochrome P450 inactivator? Drug Metab Dispos. 2009 Jan;37(1):10-3. DMAL4G0 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=18936109 DMAL4G0 DI DMAL4G0 DMAL4G0 DN Flurazepam DMAL4G0 MI DE4LYSA DMAL4G0 MN Cytochrome P450 3A4 (CYP3A4) DMAL4G0 MT DME DMAL4G0 MA Metabolism DMAL4G0 RN Is 1-aminobenzotriazole an appropriate in vitro tool as a nonspecific cytochrome P450 inactivator? Drug Metab Dispos. 2009 Jan;37(1):10-3. DMAL4G0 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=18936109 DMAL4G0 DI DMAL4G0 DMAL4G0 DN Flurazepam DMAL4G0 MI TTPTXIN DMAL4G0 MN Translocator protein (TSPO) DMAL4G0 MT DTT DMAL4G0 MA Modulator DMAL4G0 RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. DMAL4G0 RU https://www.fda.gov/ DMGN4BY DI DMGN4BY DMGN4BY DN Flurbiprofen DMGN4BY MI DE5IED8 DMGN4BY MN Cytochrome P450 2C9 (CYP2C9) DMGN4BY MT DME DMGN4BY MA Metabolism DMGN4BY RN Effect of CYP2C9 genetic polymorphism on the metabolism of flurbiprofen in vitro. Drug Dev Ind Pharm. 2015;41(8):1363-7. DMGN4BY RU https://www.ncbi.nlm.nih.gov/pubmed/?term=25144335 DMGN4BY DI DMGN4BY DMGN4BY DN Flurbiprofen DMGN4BY MI TTVKILB DMGN4BY MN Prostaglandin G/H synthase 2 (COX-2) DMGN4BY MT DTT DMGN4BY MA Modulator DMGN4BY RN Flurbiprofen, a cyclooxygenase inhibitor, protects mice from hepatic ischemia/reperfusion injury by inhibiting GSK-3 signaling and mitochondrial permeability transition.Mol Med.2012 Sep 25;18:1128-35. DMGN4BY RU https://www.ncbi.nlm.nih.gov/pubmed/22714712 DMGN4BY DI DMGN4BY DMGN4BY DN Flurbiprofen DMGN4BY MI DEYGVN4 DMGN4BY MN UDP-glucuronosyltransferase 1A1 (UGT1A1) DMGN4BY MT DME DMGN4BY MA Metabolism DMGN4BY RN Predominant contribution of UDP-glucuronosyltransferase 2B7 in the glucuronidation of racemic flurbiprofen in the human liver. Drug Metab Dispos. 2007 Jul;35(7):1182-7. DMGN4BY RU https://www.ncbi.nlm.nih.gov/pubmed/?term=17446261 DMGN4BY DI DMGN4BY DMGN4BY DN Flurbiprofen DMGN4BY MI DEF2WXN DMGN4BY MN UDP-glucuronosyltransferase 1A3 (UGT1A3) DMGN4BY MT DME DMGN4BY MA Metabolism DMGN4BY RN Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. DMGN4BY RU https://www.ncbi.nlm.nih.gov/pubmed/?term=19515014 DMGN4BY DI DMGN4BY DMGN4BY DN Flurbiprofen DMGN4BY MI DE85D2P DMGN4BY MN UDP-glucuronosyltransferase 1A9 (UGT1A9) DMGN4BY MT DME DMGN4BY MA Metabolism DMGN4BY RN Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. DMGN4BY RU https://www.ncbi.nlm.nih.gov/pubmed/?term=19515014 DMGN4BY DI DMGN4BY DMGN4BY DN Flurbiprofen DMGN4BY MI DEB3CV1 DMGN4BY MN UDP-glucuronosyltransferase 2B7 (UGT2B7) DMGN4BY MT DME DMGN4BY MA Metabolism DMGN4BY RN Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. 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Urology. 2002 Sep;60(3 Suppl 1):132-8; discussion 138-9. DMK0O7U RU https://pubmed.ncbi.nlm.nih.gov/12231070 DMK0O7U DI DMK0O7U DMK0O7U DN Flutamide DMK0O7U MI DE6OQ3W DMK0O7U MN Cytochrome P450 1A1 (CYP1A1) DMK0O7U MT DME DMK0O7U MA Metabolism DMK0O7U RN Human CYP1B1 and anticancer agent metabolism: mechanism for tumor-specific drug inactivation? J Pharmacol Exp Ther. 2001 Feb;296(2):537-41. DMK0O7U RU https://www.ncbi.nlm.nih.gov/pubmed/?term=11160641 DMK0O7U DI DMK0O7U DMK0O7U DN Flutamide DMK0O7U MI DEJGDUW DMK0O7U MN Cytochrome P450 1A2 (CYP1A2) DMK0O7U MT DME DMK0O7U MA Metabolism DMK0O7U RN Metabolism of the antiandrogenic drug (Flutamide) by human CYP1A2. Drug Metab Dispos. 1997 Nov;25(11):1298-303. DMK0O7U RU https://www.ncbi.nlm.nih.gov/pubmed/?term=9351907 DMK0O7U DI DMK0O7U DMK0O7U DN Flutamide DMK0O7U MI DE9QHP6 DMK0O7U MN Cytochrome P450 1B1 (CYP1B1) DMK0O7U MT DME DMK0O7U MA Metabolism DMK0O7U RN Human CYP1B1 and anticancer agent metabolism: mechanism for tumor-specific drug inactivation? J Pharmacol Exp Ther. 2001 Feb;296(2):537-41. DMK0O7U RU https://www.ncbi.nlm.nih.gov/pubmed/?term=11160641 DMK0O7U DI DMK0O7U DMK0O7U DN Flutamide DMK0O7U MI DE4LYSA DMK0O7U MN Cytochrome P450 3A4 (CYP3A4) DMK0O7U MT DME DMK0O7U MA Metabolism DMK0O7U RN Identification of a novel glutathione conjugate of flutamide in incubations with human liver microsomes. Drug Metab Dispos. 2007 Jul;35(7):1081-8. DMK0O7U RU https://www.ncbi.nlm.nih.gov/pubmed/?term=17403914 DMK0O7U DI DMK0O7U DMK0O7U DN Flutamide DMK0O7U MI DEIBDNY DMK0O7U MN Cytochrome P450 3A5 (CYP3A5) DMK0O7U MT DME DMK0O7U MA Metabolism DMK0O7U RN Identification of a novel glutathione conjugate of flutamide in incubations with human liver microsomes. Drug Metab Dispos. 2007 Jul;35(7):1081-8. DMK0O7U RU https://www.ncbi.nlm.nih.gov/pubmed/?term=17403914 DMK0O7U DI DMK0O7U DMK0O7U DN Flutamide DMK0O7U MI DEGTFWK DMK0O7U MN Mephenytoin 4-hydroxylase (CYP2C19) DMK0O7U MT DME DMK0O7U MA Metabolism DMK0O7U RN Identification of a novel glutathione conjugate of flutamide in incubations with human liver microsomes. Drug Metab Dispos. 2007 Jul;35(7):1081-8. 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DM4MDJY RU https://www.ncbi.nlm.nih.gov/pubmed/?term=22594566 DM4MDJY DI DM4MDJY DM4MDJY DN Fluvastatin DM4MDJY MI DECB0K3 DM4MDJY MN Cytochrome P450 2D6 (CYP2D6) DM4MDJY MT DME DM4MDJY MA Metabolism DM4MDJY RN Clinical pharmacokinetics of fluvastatin. Clin Pharmacokinet. 2001;40(4):263-81. DM4MDJY RU https://www.ncbi.nlm.nih.gov/pubmed/?term=11368292 DM4MDJY DI DM4MDJY DM4MDJY DN Fluvastatin DM4MDJY MI DE4LYSA DM4MDJY MN Cytochrome P450 3A4 (CYP3A4) DM4MDJY MT DME DM4MDJY MA Metabolism DM4MDJY RN Effects of fluvastatin on the pharmacokinetics of eepaglinide: possible role of CYP3A4 and P-glycoprotein inhibition by fluvastatin. Korean J Physiol Pharmacol. 2013 Jun;17(3):245-51. DM4MDJY RU https://www.ncbi.nlm.nih.gov/pubmed/?term=23776402 DM4MDJY DI DM4MDJY DM4MDJY DN Fluvastatin DM4MDJY MI DEIBDNY DM4MDJY MN Cytochrome P450 3A5 (CYP3A5) DM4MDJY MT DME DM4MDJY MA Metabolism DM4MDJY RN Lipid-lowering response to statins is affected by CYP3A5 polymorphism. Pharmacogenetics. 2004 Aug;14(8):523-5. DM4MDJY RU https://www.ncbi.nlm.nih.gov/pubmed/?term=15284534 DM4MDJY DI DM4MDJY DM4MDJY DN Fluvastatin DM4MDJY MI TTPADOQ DM4MDJY MN HMG-CoA reductase (HMGCR) DM4MDJY MT DTT DM4MDJY MA Inhibitor DM4MDJY RN Equally potent inhibitors of cholesterol synthesis in human hepatocytes have distinguishable effects on different cytochrome P450 enzymes. Biopharm Drug Dispos. 2000 Dec;21(9):353-64. DM4MDJY RU https://pubmed.ncbi.nlm.nih.gov/11523064 DM4MDJY DI DM4MDJY DM4MDJY DN Fluvastatin DM4MDJY MI DT3D8F0 DM4MDJY MN Organic anion transporting polypeptide 1B1 (SLCO1B1) DM4MDJY MT DTP DM4MDJY MA Substrate DM4MDJY RN SLCO1B1 polymorphism and sex affect the pharmacokinetics of pravastatin but not fluvastatin. Clin Pharmacol Ther. 2006 Oct;80(4):356-66. 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DMEMBJC RU https://pubmed.ncbi.nlm.nih.gov/16859665 DMEMBJC DI DMEMBJC DMEMBJC DN Folic acid DMEMBJC MI DTOSN46 DMEMBJC MN Folate transporter 1 (SLC19A1) DMEMBJC MT DTP DMEMBJC MA Substrate DMEMBJC RN Biology of the major facilitative folate transporters SLC19A1 and SLC46A1. Curr Top Membr. 2014;73:175-204. DMEMBJC RU http://www.ncbi.nlm.nih.gov/pubmed/24745983 DMEMBJC DI DMEMBJC DMEMBJC DN Folic acid DMEMBJC MI DEW0GI5 DMEMBJC MN Folylpolyglutamate synthetase (fpgS) DMEMBJC MT DME DMEMBJC MA Metabolism DMEMBJC RN Mutagenesis of folylpolyglutamate synthetase indicates that dihydropteroate and tetrahydrofolate bind to the same site. Biochemistry. 2008 Feb 26;47(8):2388-96. DMEMBJC RU https://pubmed.ncbi.nlm.nih.gov/18232714 DMEMBJC DI DMEMBJC DMEMBJC DN Folic acid DMEMBJC MI DEU7MWJ DMEMBJC MN Gamma-Glu-X carboxypeptidase (GGH) DMEMBJC MT DME DMEMBJC MA Metabolism DMEMBJC RN Optimization of the trienzyme extraction for the microbiological assay of folate in vegetables. 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DMEMBJC RU https://www.ncbi.nlm.nih.gov/pubmed/?term=21462116 DMEMBJC DI DMEMBJC DMEMBJC DN Folic acid DMEMBJC MI DTM8E7H DMEMBJC MN Mitochondrial folate transporter/carrier (SLC25A32) DMEMBJC MT DTP DMEMBJC MA Substrate DMEMBJC RN Polymorphism of SLC25A32, the folate transporter gene, is associated with plasma folate levels and bone fractures in Japanese postmenopausal women. Geriatr Gerontol Int. 2014 Oct;14(4):942-6. DMEMBJC RU http://www.ncbi.nlm.nih.gov/pubmed/24354357 DMEMBJC DI DMEMBJC DMEMBJC DN Folic acid DMEMBJC MI DTSYQGK DMEMBJC MN Multidrug resistance-associated protein 1 (ABCC1) DMEMBJC MT DTP DMEMBJC MA Substrate DMEMBJC RN Folate concentration dependent transport activity of the Multidrug Resistance Protein 1 (ABCC1). Biochem Pharmacol. 2004 Apr 15;67(8):1541-8. DMEMBJC RU http://www.ncbi.nlm.nih.gov/pubmed/15041471 DMEMBJC DI DMEMBJC DMEMBJC DN Folic acid DMEMBJC MI DTFI42L DMEMBJC MN Multidrug resistance-associated protein 2 (ABCC2) DMEMBJC MT DTP DMEMBJC MA Substrate DMEMBJC RN Mammalian multidrug-resistance proteins (MRPs). Essays Biochem. 2011 Sep 7;50(1):179-207. DMEMBJC RU https://doi.org/10.1042/bse0500179 DMEMBJC DI DMEMBJC DMEMBJC DN Folic acid DMEMBJC MI DTQ3ZHF DMEMBJC MN Multidrug resistance-associated protein 3 (ABCC3) DMEMBJC MT DTP DMEMBJC MA Substrate DMEMBJC RN Transport of methotrexate (MTX) and folates by multidrug resistance protein (MRP) 3 and MRP1: effect of polyglutamylation on MTX transport. Cancer Res. 2001 Oct 1;61(19):7225-32. DMEMBJC RU http://www.ncbi.nlm.nih.gov/pubmed/11585759 DMEMBJC DI DMEMBJC DMEMBJC DN Folic acid DMEMBJC MI DTCSGPB DMEMBJC MN Multidrug resistance-associated protein 4 (ABCC4) DMEMBJC MT DTP DMEMBJC MA Substrate DMEMBJC RN Analysis of methotrexate and folate transport by multidrug resistance protein 4 (ABCC4): MRP4 is a component of the methotrexate efflux system. Cancer Res. 2002 Jun 1;62(11):3144-50. DMEMBJC RU http://www.ncbi.nlm.nih.gov/pubmed/12036927 DMEMBJC DI DMEMBJC DMEMBJC DN Folic acid DMEMBJC MI DTYVM24 DMEMBJC MN Multidrug resistance-associated protein 5 (ABCC5) DMEMBJC MT DTP DMEMBJC MA Substrate DMEMBJC RN The human multidrug resistance protein MRP5 transports folates and can mediate cellular resistance against antifolates. Cancer Res. 2005 May 15;65(10):4425-30. DMEMBJC RU http://www.ncbi.nlm.nih.gov/pubmed/15899835 DMEMBJC DI DMEMBJC DMEMBJC DN Folic acid DMEMBJC MI DTUGYRD DMEMBJC MN P-glycoprotein 1 (ABCB1) DMEMBJC MT DTP DMEMBJC MA Substrate DMEMBJC RN Folate transporter expression decreases in the human placenta throughout pregnancy and in pre-eclampsia. Pregnancy Hypertens. 2012 Apr;2(2):123-31. DMEMBJC RU http://www.ncbi.nlm.nih.gov/pubmed/26105097 DMEMBJC DI DMEMBJC DMEMBJC DN Folic acid DMEMBJC MI TTY8Z2E DMEMBJC MN Proton-coupled folate transporter (SLC46A1) DMEMBJC MT DTT DMEMBJC MA Modulator DMEMBJC RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1213). 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DMEMBJC RU https://www.ncbi.nlm.nih.gov/pubmed/?term=1329759 DMEMBJC DI DMEMBJC DMEMBJC DN Folic acid DMEMBJC MI DTKWJH3 DMEMBJC MN Sodium-coupled neutral amino acid transporter 3 (SLC38A3) DMEMBJC MT DTP DMEMBJC MA Substrate DMEMBJC RN Purification of recombinant human N-acetyltransferase type 1 (NAT1) expressed in E. coli and characterization of its potential role in folate metabolism. Biochem Pharmacol. 1995 Jun 16;49(12):1759-67. DMEMBJC RU http://www.ncbi.nlm.nih.gov/pubmed/7598738 DMEMBJC DI DMEMBJC DMEMBJC DN Folic acid DMEMBJC MI TT09I7D DMEMBJC MN Solute carrier family 19 member 1 (SLC19A1) DMEMBJC MT DTT DMEMBJC MA Modulator DMEMBJC RN Increased activity of a novel low pH folate transporter associated with lipophilic antifolate resistance in chinese hamster ovary cells. J Biol Chem. 1998 Apr 3;273(14):8106-11. DMEMBJC RU https://pubmed.ncbi.nlm.nih.gov/9525913 DMEMBJC DI DMEMBJC DMEMBJC DN Folic acid DMEMBJC MI DEWSHL5 DMEMBJC MN Vitamin B12 methionine synthase (MTR) DMEMBJC MT DME DMEMBJC MA Metabolism DMEMBJC RN Metabolic derangement of methionine and folate metabolism in mice deficient in methionine synthase reductase. Mol Genet Metab. 2007 May;91(1):85-97. DMEMBJC RU https://www.ncbi.nlm.nih.gov/pubmed/?term=17369066 DM2JTS5 DI DM2JTS5 DM2JTS5 DN Follitropin beta DM2JTS5 MI TTZFDBT DM2JTS5 MN Follicle-stimulating hormone receptor (FSHR) DM2JTS5 MT DTT DM2JTS5 MA Binder DM2JTS5 RN Follitropin-alpha (Gonal-F) versus follitropin-beta (Puregon) in controlled ovarian hyperstimulation for in vitro fertilization: is there any diffe... Fertil Steril. 2009 Apr;91(4 Suppl):1522-5. DM2JTS5 RU https://pubmed.ncbi.nlm.nih.gov/18851846 DM6VOWQ DI DM6VOWQ DM6VOWQ DN Fomepizole DM6VOWQ MI TT5AHZ0 DM6VOWQ MN Alcohol dehydrogenase 1A (ADH1A) DM6VOWQ MT DTT DM6VOWQ MA Modulator DM6VOWQ RN Drugs@FDA. 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Pathophysiol Haemost Thromb. 2002 Sep-Dec;32(5-6):218-24. DMWS3FH RU https://pubmed.ncbi.nlm.nih.gov/13679646 DMRBJNZ DI DMRBJNZ DMRBJNZ DN Forasartan DMRBJNZ MI TT8DBY3 DMRBJNZ MN Angiotensin II receptor type-1 (AGTR1) DMRBJNZ MT DTT DMRBJNZ MA Antagonist DMRBJNZ RN Non-peptide angiotensin II receptor antagonists: chemical feature based pharmacophore identification. J Med Chem. 2003 Feb 27;46(5):716-26. DMRBJNZ RU https://pubmed.ncbi.nlm.nih.gov/12593652 DMSOURV DI DMSOURV DMSOURV DN Formoterol DMSOURV MI TT2CJVK DMSOURV MN Adrenergic receptor beta-2 (ADRB2) DMSOURV MT DTT DMSOURV MA Agonist DMSOURV RN Long-acting beta2-agonists for chronic obstructive pulmonary disease patients with poorly reversible airflow limitation. Cochrane Database Syst Rev. 2002;(3):CD001104. DMSOURV RU https://pubmed.ncbi.nlm.nih.gov/12137617 DMSOURV DI DMSOURV DMSOURV DN Formoterol DMSOURV MI DE5IED8 DMSOURV MN Cytochrome P450 2C9 (CYP2C9) DMSOURV MT DME DMSOURV MA Metabolism DMSOURV RN FDA Label of Formoterol. The 2020 official website of the U.S. Food and Drug Administration. DMSOURV RU https://www.accessdata.fda.gov/drugsatfda_docs/label/2012/020831s028lbl.pdf DMSOURV DI DMSOURV DMSOURV DN Formoterol DMSOURV MI DECB0K3 DMSOURV MN Cytochrome P450 2D6 (CYP2D6) DMSOURV MT DME DMSOURV MA Metabolism DMSOURV RN A comparison of the expression and metabolizing activities of phase I and II enzymes in freshly isolated human lung parenchymal cells and cryopreserved human hepatocytes. Drug Metab Dispos. 2007 Oct;35(10):1797-805. DMSOURV RU https://www.ncbi.nlm.nih.gov/pubmed/?term=17627976 DMSOURV DI DMSOURV DMSOURV DN Formoterol DMSOURV MI DEGTFWK DMSOURV MN Mephenytoin 4-hydroxylase (CYP2C19) DMSOURV MT DME DMSOURV MA Metabolism DMSOURV RN A comparison of the expression and metabolizing activities of phase I and II enzymes in freshly isolated human lung parenchymal cells and cryopreserved human hepatocytes. Drug Metab Dispos. 2007 Oct;35(10):1797-805. DMSOURV RU https://www.ncbi.nlm.nih.gov/pubmed/?term=17627976 DMSOURV DI DMSOURV DMSOURV DN Formoterol DMSOURV MI DTT79CX DMSOURV MN Organic cation transporter 1 (SLC22A1) DMSOURV MT DTP DMSOURV MA Substrate DMSOURV RN Identification of novel substrates and structure-activity relationship of cellular uptake mediated by human organic cation transporters 1 and 2. J Med Chem. 2013 Sep 26;56(18):7232-42. DMSOURV RU http://www.ncbi.nlm.nih.gov/pubmed/23984907 DM4W9B3 DI DM4W9B3 DM4W9B3 DN Fosamprenavir DM4W9B3 MI DE4LYSA DM4W9B3 MN Cytochrome P450 3A4 (CYP3A4) DM4W9B3 MT DME DM4W9B3 MA Metabolism DM4W9B3 RN Fosamprenavir : clinical pharmacokinetics and drug interactions of the amprenavir prodrug. Clin Pharmacokinet. 2006;45(2):137-68. DM4W9B3 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=16485915 DM4W9B3 DI DM4W9B3 DM4W9B3 DN Fosamprenavir DM4W9B3 MI TT5FNQT DM4W9B3 MN Human immunodeficiency virus Protease (HIV PR) DM4W9B3 MT DTT DM4W9B3 MA Inhibitor DM4W9B3 RN Fosamprenavir/ritonavir in advanced HIV disease (TRIAD): a randomized study of high-dose, dual-boosted or standard dose fosamprenavir/ritonavir in ... J Antimicrob Chemother. 2009 Aug;64(2):398-410. DM4W9B3 RU https://pubmed.ncbi.nlm.nih.gov/19515730 DM4W9B3 DI DM4W9B3 DM4W9B3 DN Fosamprenavir DM4W9B3 MI DTUGYRD DM4W9B3 MN P-glycoprotein 1 (ABCB1) DM4W9B3 MT DTP DM4W9B3 MA Substrate DM4W9B3 RN Tarascon Pocket Pharmacopoeia 2018 Classic Shirt-Pocket Edition. DM4W9B3 RU https://books.google.com/books?id=0gBRDwAAQBAJ&pg=PP37&lpg=PP37&dq=Methylergonovine+transporter+uptake+efflex&source=bl&ots=cUTe_ppsmZ&sig=ACfU3U3E_YqrDg0CNEuj8K-7lci47HAnrg&hl=zh-CN&sa=X&ved=2ahUKEwjnj-Dk7d7iAhUsK6YKHd5DBDkQ6AEwEnoECAgQAQ#v=onepage&q&f=false DM9KJLZ DI DM9KJLZ DM9KJLZ DN Foscavir DM9KJLZ MI TTIU7X1 DM9KJLZ MN Herpes simplex virus DNA polymerase UL30 (HSV UL30) DM9KJLZ MT DTT DM9KJLZ MA Inhibitor DM9KJLZ RN Drug targets in cytomegalovirus infection. Infect Disord Drug Targets. 2009 Apr;9(2):201-22. DM9KJLZ RU https://pubmed.ncbi.nlm.nih.gov/19275707 DMR0TYK DI DMR0TYK DMR0TYK DN Fosdenopterin DMR0TYK MI TT7RJY8 DMR0TYK MN Xanthine dehydrogenase/oxidase (XDH) DMR0TYK MT DTT DMR0TYK MA Cofactor DMR0TYK RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health Human Services. 2021 DMR0TYK RU https://www.accessdata.fda.gov/drugsatfda_docs/label/2021/214018s000lbl.pdf DMD072M DI DMD072M DMD072M DN Fosfestrol DMD072M MI TTZAYWL DMD072M MN Estrogen receptor (ESR) DMD072M MT DTT DMD072M MA Modulator DMD072M RN Impact of natural products on developing new anti-cancer agents. Chem Rev. 2009 Jul;109(7):3012-43. DMD072M RU https://pubmed.ncbi.nlm.nih.gov/19422222 DMVGPMX DI DMVGPMX DMVGPMX DN Fosfomycin DMVGPMX MI TTICX3S DMVGPMX MN Bacterial UDP-N-acetylglucosamine carboxyvinyltransferase (Bact murA) DMVGPMX MT DTT DMVGPMX MA Inhibitor DMVGPMX RN Evidence that the fosfomycin target Cys115 in UDP-N-acetylglucosamine enolpyruvyl transferase (MurA) is essential for product release. J Biol Chem. 2005 Feb 4;280(5):3757-63. DMVGPMX RU https://pubmed.ncbi.nlm.nih.gov/15531591 DMVGPMX DI DMVGPMX DMVGPMX DN Fosfomycin DMVGPMX MI DE4ZHS1 DMVGPMX MN Glutathione S-transferase alpha-1 (GSTA1) DMVGPMX MT DME DMVGPMX MA Metabolism DMVGPMX RN Formation of an adduct between fosfomycin and glutathione: a new mechanism of antibiotic resistance in bacteria. Antimicrob Agents Chemother. 1988 Oct;32(10):1552-6. DMVGPMX RU https://www.ncbi.nlm.nih.gov/pubmed/?term=3056239 DMDIC39 DI DMDIC39 DMDIC39 DN Fosfosal DMDIC39 MI TTK0943 DMDIC39 MN Prostaglandin G/H synthase (COX) DMDIC39 MT DTT DMDIC39 MA Modulator DMDIC39 RN Natural products as sources of new drugs over the last 25 years. J Nat Prod. 2007 Mar;70(3):461-77. DMDIC39 RU https://pubmed.ncbi.nlm.nih.gov/17309302 DM9NJ52 DI DM9NJ52 DM9NJ52 DN Fosinopril DM9NJ52 MI TTL69WB DM9NJ52 MN Angiotensin-converting enzyme (ACE) DM9NJ52 MT DTT DM9NJ52 MA Inhibitor DM9NJ52 RN Angiotensin-converting enzyme inhibition and novel cardiovascular risk biomarkers: results from the Trial of Angiotensin Converting Enzyme Inhibition and Novel Cardiovascular Risk Factors (TRAIN) study. Am Heart J. 2009 Feb;157(2):334.e1-8. DM9NJ52 RU https://pubmed.ncbi.nlm.nih.gov/19185642 DM9NJ52 DI DM9NJ52 DM9NJ52 DN Fosinopril DM9NJ52 MI DT9G7XN DM9NJ52 MN Peptide transporter 1 (SLC15A1) DM9NJ52 MT DTP DM9NJ52 MA Substrate DM9NJ52 RN Transport of angiotensin-converting enzyme inhibitors by H+/peptide transporters revisited. J Pharmacol Exp Ther. 2008 Nov;327(2):432-41. DM9NJ52 RU http://www.ncbi.nlm.nih.gov/pubmed/18713951 DM9NJ52 DI DM9NJ52 DM9NJ52 DN Fosinopril DM9NJ52 MI DT8QKNP DM9NJ52 MN Peptide transporter 2 (SLC15A2) DM9NJ52 MT DTP DM9NJ52 MA Substrate DM9NJ52 RN Mechanism of intestinal absorption and renal reabsorption of an orally active ace inhibitor: uptake and transport of fosinopril in cell cultures. Drug Metab Dispos. 2001 Oct;29(10):1307-15. DM9NJ52 RU http://www.ncbi.nlm.nih.gov/pubmed/11560874 DM7G0EP DI DM7G0EP DM7G0EP DN Fosmidomycin DM7G0EP MI TTLH4J3 DM7G0EP MN Plasmodium DOXP reductoisomerase (Malaria DXR) DM7G0EP MT DTT DM7G0EP MA Binder DM7G0EP RN Structural basis of fosmidomycin action revealed by the complex with 2-C-methyl-D-erythritol 4-phosphate synthase (IspC). Implications for the cata... J Biol Chem. 2003 May 16;278(20):18401-7. DM7G0EP RU https://pubmed.ncbi.nlm.nih.gov/12621040 DMOX3LB DI DMOX3LB DMOX3LB DN Fosphenytoin DMOX3LB MI DE5IED8 DMOX3LB MN Cytochrome P450 2C9 (CYP2C9) DMOX3LB MT DME DMOX3LB MA Metabolism DMOX3LB RN Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. DMOX3LB RU https://www.ncbi.nlm.nih.gov/pubmed/?term=19515014 DMOX3LB DI DMOX3LB DMOX3LB DN Fosphenytoin DMOX3LB MI DE4LYSA DMOX3LB MN Cytochrome P450 3A4 (CYP3A4) DMOX3LB MT DME DMOX3LB MA Metabolism DMOX3LB RN Basic review of the cytochrome p450 system. J Adv Pract Oncol. 2013 Jul;4(4):263-8. DMOX3LB RU https://www.ncbi.nlm.nih.gov/pubmed/?term=25032007 DMOX3LB DI DMOX3LB DMOX3LB DN Fosphenytoin DMOX3LB MI DEGTFWK DMOX3LB MN Mephenytoin 4-hydroxylase (CYP2C19) DMOX3LB MT DME DMOX3LB MA Metabolism DMOX3LB RN CYP2C9, CYP2C19, and ABCB1 genotype and hospitalization for phenytoin toxicity. J Clin Pharmacol. 2009 Dec;49(12):1483-7. DMOX3LB RU https://www.ncbi.nlm.nih.gov/pubmed/?term=19617466 DMOX3LB DI DMOX3LB DMOX3LB DN Fosphenytoin DMOX3LB MI TTZOVE0 DMOX3LB MN Voltage-gated sodium channel alpha Nav1.5 (SCN5A) DMOX3LB MT DTT DMOX3LB MA Blocker DMOX3LB RN Lacosamide: a new approach to target voltage-gated sodium currents in epileptic disorders. CNS Drugs. 2009;23(7):555-68. DMOX3LB RU https://pubmed.ncbi.nlm.nih.gov/19552484 DM8J5XT DI DM8J5XT DM8J5XT DN Fospropofol DM8J5XT MI DEVEFKM DM8J5XT MN Alkaline phosphatase (ALPL) DM8J5XT MT DME DM8J5XT MA Metabolism DM8J5XT RN A double-blind, randomized, multicenter, dose-ranging study to evaluate the safety and efficacy of fospropofol disodium as an intravenous sedative for colonoscopy in high-risk populations. Am J Ther. 2013 Mar-Apr;20(2):163-71. DM8J5XT RU https://www.ncbi.nlm.nih.gov/pubmed/?term=22820718 DMKLJRD DI DMKLJRD DMKLJRD DN Fospropofol disodium DMKLJRD MI TTAN6JD DMKLJRD MN Glutamate receptor AMPA (GRIA) DMKLJRD MT DTT DMKLJRD MA Modulator DMKLJRD RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015 DMKLJRD RU https://www.accessdata.fda.gov/scripts/cder/drugsatfda/ DM6AUHV DI DM6AUHV DM6AUHV DN Fostamatinib DM6AUHV MI DTKVEXO DM6AUHV MN ATP-binding cassette sub-family B member 5 (ABCB5) DM6AUHV MT DTP DM6AUHV MA Substrate DM6AUHV RN DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. (ID: DB12010) DM6AUHV RU https://www.drugbank.ca/drugs/DB12010 DM6AUHV DI DM6AUHV DM6AUHV DN Fostamatinib DM6AUHV MI DE4LYSA DM6AUHV MN Cytochrome P450 3A4 (CYP3A4) DM6AUHV MT DME DM6AUHV MA Metabolism DM6AUHV RN Effects of CYP3A4 inhibitors ketoconazole and verapamil and the CYP3A4 inducer rifampicin on the pharmacokinetic parameters of fostamatinib: results from In vitro and phase I clinical studies. Drugs R D. 2016 Mar;16(1):81-92. DM6AUHV RU https://www.ncbi.nlm.nih.gov/pubmed/?term=26739683 DM6AUHV DI DM6AUHV DM6AUHV DN Fostamatinib DM6AUHV MI TTOU65C DM6AUHV MN Tyrosine-protein kinase SYK (SYK) DM6AUHV MT DTT DM6AUHV MA Modulator DM6AUHV RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2230). DM6AUHV RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2230 DM50ILT DI DM50ILT DM50ILT DN Fostemsavir DM50ILT MI TTBYP1X DM50ILT MN Human immunodeficiency virus Envelope glycoprotein gp120 (HIV gp120) DM50ILT MT DTT DM50ILT MA Inhibitor DM50ILT RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2020 DM50ILT RU https://www.accessdata.fda.gov/drugsatfda_docs/label/2020/212950s000lbl.pdf DMV62ED DI DMV62ED DMV62ED DN Fotemustine DMV62ED MI TTR7UJ3 DMV62ED MN Cytoplasmic thioredoxin reductase (TXNRD1) DMV62ED MT DTT DMV62ED MA Inhibitor DMV62ED RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMV62ED RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMF8DNE DI DMF8DNE DMF8DNE DN Framycetin DMF8DNE MI DEJADS9 DMF8DNE MN Aminoglycoside N-acetyltransferase (aacC2) DMF8DNE MT DME DMF8DNE MA Metabolism DMF8DNE RN Relationship between antimicrobial resistance and aminoglycoside-modifying enzyme gene expressions in Acinetobacter baumannii. Chin Med J (Engl). 2005 Jan 20;118(2):141-5. DMF8DNE RU https://pubmed.ncbi.nlm.nih.gov/15667800 DMF8DNE DI DMF8DNE DMF8DNE DN Framycetin DMF8DNE MI DEWPAJD DMF8DNE MN Aminoglycoside O-phosphotransferase (aphA6) DMF8DNE MT DME DMF8DNE MA Metabolism DMF8DNE RN Relationship between antimicrobial resistance and aminoglycoside-modifying enzyme gene expressions in Acinetobacter baumannii. Chin Med J (Engl). 2005 Jan 20;118(2):141-5. DMF8DNE RU https://pubmed.ncbi.nlm.nih.gov/15667800 DMF8DNE DI DMF8DNE DMF8DNE DN Framycetin DMF8DNE MI TT38DW5 DMF8DNE MN Bacterial 16S ribosomal RNA (Bact 16S rRNA) DMF8DNE MT DTT DMF8DNE MA Binder DMF8DNE RN Antistaphylococcal activity of gentamicin. Minerva Med. 1975 Dec 8;66(84):4505-26. DMF8DNE RU https://pubmed.ncbi.nlm.nih.gov/1105242 DMF8DNE DI DMF8DNE DMF8DNE DN Framycetin DMF8DNE MI TTQ8KVI DMF8DNE MN Staphylococcus 30S ribosomal subunit (Stap-coc pbp2) DMF8DNE MT DTT DMF8DNE MA Binder DMF8DNE RN Characterization of a 30S ribosomal subunit assembly intermediate found in Escherichia coli cells growing with neomycin or paromomycin. Arch Microbiol. 2008 May;189(5):441-9. DMF8DNE RU https://pubmed.ncbi.nlm.nih.gov/18060665 DMDZY54 DI DMDZY54 DMDZY54 DN Fremanezumab DMDZY54 MI TTY6O0Q DMDZY54 MN Calcitonin gene-related peptide receptor (CGRPR) DMDZY54 MT DTT DMDZY54 MA Modulator DMDZY54 RN 2018 FDA drug approvals.Nat Rev Drug Discov. 2019 Feb;18(2):85-89. DMDZY54 RU https://pubmed.ncbi.nlm.nih.gov/30710142 DM7RE8P DI DM7RE8P DM7RE8P DN Frovatriptan DM7RE8P MI TTK8CXU DM7RE8P MN 5-HT 1B receptor (HTR1B) DM7RE8P MT DTT DM7RE8P MA Modulator DM7RE8P RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. DM7RE8P RU https://www.fda.gov/ DM7RE8P DI DM7RE8P DM7RE8P DN Frovatriptan DM7RE8P MI TT6MSOK DM7RE8P MN 5-HT 1D receptor (HTR1D) DM7RE8P MT DTT DM7RE8P MA Modulator DM7RE8P RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. DM7RE8P RU https://www.fda.gov/ DM7RE8P DI DM7RE8P DM7RE8P DN Frovatriptan DM7RE8P MI DEJGDUW DM7RE8P MN Cytochrome P450 1A2 (CYP1A2) DM7RE8P MT DME DM7RE8P MA Metabolism DM7RE8P RN Frovatriptan: a review of drug-drug interactions. Headache. 2002 Apr;42 Suppl 2:S63-73. DM7RE8P RU https://www.ncbi.nlm.nih.gov/pubmed/?term=12028322 DM43AN2 DI DM43AN2 DM43AN2 DN Fructose DM43AN2 MI TTMS54D DM43AN2 MN Fragile histidine triad protein (FHIT) DM43AN2 MT DTT DM43AN2 MA Inhibitor DM43AN2 RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DM43AN2 RU https://pubmed.ncbi.nlm.nih.gov/17139284 DM43AN2 DI DM43AN2 DM43AN2 DN Fructose DM43AN2 MI DTOR02F DM43AN2 MN Glucose transporter type 5, small intestine (SLC2A5) DM43AN2 MT DTP DM43AN2 MA Substrate DM43AN2 RN Dexamethasone sensitizes the neonatal intestine to fructose induction of intestinal fructose transporter (Slc2A5) function. Endocrinology. 2008 Jan;149(1):409-23. DM43AN2 RU http://www.ncbi.nlm.nih.gov/pubmed/17947353 DM43AN2 DI DM43AN2 DM43AN2 DN Fructose DM43AN2 MI DT8SQBG DM43AN2 MN Glucose transporter type 7 (SLC2A7) DM43AN2 MT DTP DM43AN2 MA Substrate DM43AN2 RN Functional Properties and Genomics of Glucose Transporters. Curr Genomics. 2007 Apr; 8(2): 113128. DM43AN2 RU http://www.ncbi.nlm.nih.gov/pubmed/18660845 DM43AN2 DI DM43AN2 DM43AN2 DN Fructose DM43AN2 MI DT1CP40 DM43AN2 MN Sodium/glucose cotransporter 4 (SLC5A9) DM43AN2 MT DTP DM43AN2 MA Substrate DM43AN2 RN SLC5A9/SGLT4, a new Na+-dependent glucose transporter, is an essential transporter for mannose, 1,5-anhydro-D-glucitol, and fructose. Life Sci. 2005 Jan 14;76(9):1039-50. DM43AN2 RU http://www.ncbi.nlm.nih.gov/pubmed/15607332 DM43AN2 DI DM43AN2 DM43AN2 DN Fructose DM43AN2 MI DEWU03P DM43AN2 MN Sorbitol dehydrogenase (SORD) DM43AN2 MT DME DM43AN2 MA Metabolism DM43AN2 RN Isolation, characterization and evaluation of the Pichia pastoris sorbitol dehydrogenase promoter for expression of heterologous proteins. Protein Expr Purif. 2013 Nov;92(1):128-33. DM43AN2 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=24075932 DM0YZC6 DI DM0YZC6 DM0YZC6 DN Fulvestrant DM0YZC6 MI DE4LYSA DM0YZC6 MN Cytochrome P450 3A4 (CYP3A4) DM0YZC6 MT DME DM0YZC6 MA Metabolism DM0YZC6 RN Fulvestrant: pharmacologic profile versus existing endocrine agents for the treatment of breast cancer. Ann Pharmacother. 2006 Sep;40(9):1572-83. DM0YZC6 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=16912252 DM0YZC6 DI DM0YZC6 DM0YZC6 DN Fulvestrant DM0YZC6 MI TTZAYWL DM0YZC6 MN Estrogen receptor (ESR) DM0YZC6 MT DTT DM0YZC6 MA Antagonist DM0YZC6 RN Beta3-tubulin is induced by estradiol in human breast carcinoma cells through an estrogen-receptor dependent pathway. Cell Motil Cytoskeleton. 2009 Jul;66(7):378-88. DM0YZC6 RU https://pubmed.ncbi.nlm.nih.gov/19466750 DM0YZC6 DI DM0YZC6 DM0YZC6 DN Fulvestrant DM0YZC6 MI DEYGVN4 DM0YZC6 MN UDP-glucuronosyltransferase 1A1 (UGT1A1) DM0YZC6 MT DME DM0YZC6 MA Metabolism DM0YZC6 RN Inactivation of the pure antiestrogen fulvestrant and other synthetic estrogen molecules by UDP-glucuronosyltransferase 1A enzymes expressed in breast tissue. Mol Pharmacol. 2006 Mar;69(3):908-20. DM0YZC6 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=16339389 DM3P6V7 DI DM3P6V7 DM3P6V7 DN Furazolidone DM3P6V7 MI TTS1W4A DM3P6V7 MN Bacterial Deoxyribonucleic acid (Bact DNA) DM3P6V7 MT DTT DM3P6V7 MA Modulator DM3P6V7 RN Interaction of furazolidone with DNA. Biochim Biophys Acta. 1975 Aug 21;402(2):161-5. DM3P6V7 RU https://www.ncbi.nlm.nih.gov/pubmed/1174533 DMMQ8ZG DI DMMQ8ZG DMMQ8ZG DN Furosemide DMMQ8ZG MI DEVDYN7 DMMQ8ZG MN Cytochrome P450 2E1 (CYP2E1) DMMQ8ZG MT DME DMMQ8ZG MA Metabolism DMMQ8ZG RN Effects of cytochrome P450 inducers and inhibitors on the pharmacokinetics of intravenous furosemide in rats: involvement of CYP2C11, 2E1, 3A1 and 3A2 in furosemide metabolism. J Pharm Pharmacol. 2009 Jan;61(1):47-54. DMMQ8ZG RU https://www.ncbi.nlm.nih.gov/pubmed/?term=19126296 DMMQ8ZG DI DMMQ8ZG DMMQ8ZG DN Furosemide DMMQ8ZG MI DTQ23VB DMMQ8ZG MN Organic anion transporter 1 (SLC22A6) DMMQ8ZG MT DTP DMMQ8ZG MA Substrate DMMQ8ZG RN Interactions of human organic anion transporters with diuretics. J Pharmacol Exp Ther. 2004 Mar;308(3):1021-9. DMMQ8ZG RU http://www.ncbi.nlm.nih.gov/pubmed/14610216 DMMQ8ZG DI DMMQ8ZG DMMQ8ZG DN Furosemide DMMQ8ZG MI DTVP67E DMMQ8ZG MN Organic anion transporter 3 (SLC22A8) DMMQ8ZG MT DTP DMMQ8ZG MA Substrate DMMQ8ZG RN Interactions of human organic anion transporters with diuretics. J Pharmacol Exp Ther. 2004 Mar;308(3):1021-9. DMMQ8ZG RU http://www.ncbi.nlm.nih.gov/pubmed/14610216 DMMQ8ZG DI DMMQ8ZG DMMQ8ZG DN Furosemide DMMQ8ZG MI DT9G7XN DMMQ8ZG MN Peptide transporter 1 (SLC15A1) DMMQ8ZG MT DTP DMMQ8ZG MA Substrate DMMQ8ZG RN Peptide transporter substrate identification during permeability screening in drug discovery: comparison of transfected MDCK-hPepT1 cells to Caco-2 cells. Arch Pharm Res. 2007 Apr;30(4):507-18. DMMQ8ZG RU https://doi.org/10.1007/BF02980227 DMMQ8ZG DI DMMQ8ZG DMMQ8ZG DN Furosemide DMMQ8ZG MI TTS087L DMMQ8ZG MN Solute carrier family 12 member 1 (SLC12A1) DMMQ8ZG MT DTT DMMQ8ZG MA Blocker DMMQ8ZG RN Update of diuretics in the treatment of hypertension. Am J Ther. 2007 Mar-Apr;14(2):154-60. DMMQ8ZG RU https://pubmed.ncbi.nlm.nih.gov/17414583 DMMQ8ZG DI DMMQ8ZG DMMQ8ZG DN Furosemide DMMQ8ZG MI DEYGVN4 DMMQ8ZG MN UDP-glucuronosyltransferase 1A1 (UGT1A1) DMMQ8ZG MT DME DMMQ8ZG MA Metabolism DMMQ8ZG RN Drug-drug interactions for UDP-glucuronosyltransferase substrates: a pharmacokinetic explanation for typically observed low exposure (AUCi/AUC) ratios. Drug Metab Dispos. 2004 Nov;32(11):1201-8. DMMQ8ZG RU https://www.ncbi.nlm.nih.gov/pubmed/?term=15304429 DMWVCF3 DI DMWVCF3 DMWVCF3 DN Fusidic acid DMWVCF3 MI DECB0K3 DMWVCF3 MN Cytochrome P450 2D6 (CYP2D6) DMWVCF3 MT DME DMWVCF3 MA Metabolism DMWVCF3 RN The potent mechanism-based inactivation of CYP2D6 and CYP3A4 with fusidic acid in in vivo bioaccumulation. Xenobiotica. 2018 Oct;48(10):999-1005. DMWVCF3 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=29027845 DMWVCF3 DI DMWVCF3 DMWVCF3 DN Fusidic acid DMWVCF3 MI TT6HP1T DMWVCF3 MN Streptococcus Elongation factor G (Stre-coc fusA) DMWVCF3 MT DTT DMWVCF3 MA Inhibitor DMWVCF3 RN Genetic determinants of resistance to fusidic acid among clinical bacteremia isolates of Staphylococcus aureus. Antimicrob Agents Chemother. 2009 May;53(5):2059-65. DMWVCF3 RU https://pubmed.ncbi.nlm.nih.gov/19289529 DMWVCF3 DI DMWVCF3 DMWVCF3 DN Fusidic acid DMWVCF3 MI DEYGVN4 DMWVCF3 MN UDP-glucuronosyltransferase 1A1 (UGT1A1) DMWVCF3 MT DME DMWVCF3 MA Metabolism DMWVCF3 RN Fusidic acid inhibits hepatic transporters and metabolic enzymes: potential cause of clinical drug-drug interaction observed with statin coadministration. Antimicrob Agents Chemother. 2016 Sep 23;60(10):5986-94. DMWVCF3 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=27458210 DMZ0P95 DI DMZ0P95 DMZ0P95 DN Ga-68-DOTATOC DMZ0P95 MI TTZ6T9E DMZ0P95 MN Somatostatin receptor type 2 (SSTR2) DMZ0P95 MT DTT DMZ0P95 MA Binder DMZ0P95 RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health Human Services. 2019 DMZ0P95 RU https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/210828s000lbl.pdf DM6T924 DI DM6T924 DM6T924 DN Gabapentin DM6T924 MI TTDCVZW DM6T924 MN Gamma-aminobutyric acid B receptor (GABBR) DM6T924 MT DTT DM6T924 MA Antagonist DM6T924 RN Gabapentin increases a tonic inhibitory conductance in hippocampal pyramidal neurons. Anesthesiology. 2006 Aug;105(2):325-33. DM6T924 RU https://pubmed.ncbi.nlm.nih.gov/16871066 DM6T924 DI DM6T924 DM6T924 DN Gabapentin DM6T924 MI DT48T0N DM6T924 MN L-type amino acid transporter 1 (SLC7A5) DM6T924 MT DTP DM6T924 MA Substrate DM6T924 RN Transport of gabapentin by LAT1 (SLC7A5). Biochem Pharmacol. 2013 Jun 1;85(11):1672-83. DM6T924 RU http://www.ncbi.nlm.nih.gov/pubmed/23567998 DM6T924 DI DM6T924 DM6T924 DN Gabapentin DM6T924 MI DT9IDPW DM6T924 MN Organic cation transporter 2 (SLC22A2) DM6T924 MT DTP DM6T924 MA Substrate DM6T924 RN Clinical pharmacokinetic drug interaction studies of gabapentin enacarbil, a novel transported prodrug of gabapentin, with naproxen and cimetidine. Br J Clin Pharmacol. 2010 May;69(5):498-507. DM6T924 RU http://www.ncbi.nlm.nih.gov/pubmed/20573085 DM6T924 DI DM6T924 DM6T924 DN Gabapentin DM6T924 MI DT2EG60 DM6T924 MN Organic cation/carnitine transporter 1 (SLC22A4) DM6T924 MT DTP DM6T924 MA Substrate DM6T924 RN Effects of genetic variation in the novel organic cation transporter, OCTN1, on the renal clearance of gabapentin. Clin Pharmacol Ther. 2008 Mar;83(3):416-21. DM6T924 RU http://www.ncbi.nlm.nih.gov/pubmed/17609685 DMU9D2F DI DMU9D2F DMU9D2F DN Gabexate DMU9D2F MI TTEMV5X DMU9D2F MN Serine protease unspecific (SP) DMU9D2F MT DTT DMU9D2F MA Inhibitor DMU9D2F RN Tryptase-positive mast cells correlate with angiogenesis in early breast cancer patients. Int J Oncol. 2009 Jul;35(1):115-20. DMU9D2F RU https://pubmed.ncbi.nlm.nih.gov/19513558 DMI53FU DI DMI53FU DMI53FU DN Gaboxadol DMI53FU MI TTGXH6N DMI53FU MN GABA(A) receptor delta (GABRD) DMI53FU MT DTT DMI53FU MA Modulator DMI53FU RN Gaboxadol--a new awakening in sleep.Curr Opin Pharmacol.2006 Feb;6(1):30-6. DMI53FU RU https://www.ncbi.nlm.nih.gov/pubmed/16368265 DMI53FU DI DMI53FU DMI53FU DN Gaboxadol DMI53FU MI DT48WEM DMI53FU MN Proton-coupled amino acid transporter 1 (SLC36A1) DMI53FU MT DTP DMI53FU MA Substrate DMI53FU RN Intestinal gaboxadol absorption via PAT1 (SLC36A1): modified absorption in vivo following co-administration of L-tryptophan. Br J Pharmacol. 2009 Aug;157(8):1380-9. DMI53FU RU http://www.ncbi.nlm.nih.gov/pubmed/19594759 DM4VAOG DI DM4VAOG DM4VAOG DN Gadobenate dimeglumine DM4VAOG MI DTFI42L DM4VAOG MN Multidrug resistance-associated protein 2 (ABCC2) DM4VAOG MT DTP DM4VAOG MA Substrate DM4VAOG RN Liver Perfusion Modifies Gd-DTPA and Gd-BOPTA Hepatocyte Concentrations Through Transfer Clearances Across Sinusoidal Membranes. Eur J Drug Metab Pharmacokinet. 2017 Aug;42(4):657-667. DM4VAOG RU http://www.ncbi.nlm.nih.gov/pubmed/27778300 DM4VAOG DI DM4VAOG DM4VAOG DN Gadobenate dimeglumine DM4VAOG MI DT3D8F0 DM4VAOG MN Organic anion transporting polypeptide 1B1 (SLCO1B1) DM4VAOG MT DTP DM4VAOG MA Substrate DM4VAOG RN Liver Perfusion Modifies Gd-DTPA and Gd-BOPTA Hepatocyte Concentrations Through Transfer Clearances Across Sinusoidal Membranes. Eur J Drug Metab Pharmacokinet. 2017 Aug;42(4):657-667. DM4VAOG RU http://www.ncbi.nlm.nih.gov/pubmed/27778300 DM4VAOG DI DM4VAOG DM4VAOG DN Gadobenate dimeglumine DM4VAOG MI DT9C1TS DM4VAOG MN Organic anion transporting polypeptide 1B3 (SLCO1B3) DM4VAOG MT DTP DM4VAOG MA Substrate DM4VAOG RN Liver Perfusion Modifies Gd-DTPA and Gd-BOPTA Hepatocyte Concentrations Through Transfer Clearances Across Sinusoidal Membranes. Eur J Drug Metab Pharmacokinet. 2017 Aug;42(4):657-667. DM4VAOG RU http://www.ncbi.nlm.nih.gov/pubmed/27778300 DM4VAOG DI DM4VAOG DM4VAOG DN Gadobenate dimeglumine DM4VAOG MI TTFNGC9 DM4VAOG MN Serum albumin (ALB) DM4VAOG MT DTT DM4VAOG MA Binder DM4VAOG RN Protocol design for high relaxivity contrast agents in MR imaging of the CNS. Eur Radiol. 2006 Nov;16 Suppl 7:M3-7. DM4VAOG RU https://pubmed.ncbi.nlm.nih.gov/18655261 DM5V9U1 DI DM5V9U1 DM5V9U1 DN Gadofosveset DM5V9U1 MI TTFNGC9 DM5V9U1 MN Serum albumin (ALB) DM5V9U1 MT DTT DM5V9U1 MA Modulator DM5V9U1 RN 2008 FDA drug approvals. Nat Rev Drug Discov. 2009 Feb;8(2):93-6. DM5V9U1 RU https://pubmed.ncbi.nlm.nih.gov/19180096 DMEO794 DI DMEO794 DMEO794 DN Galantamine DMEO794 MI TT1RS9F DMEO794 MN Acetylcholinesterase (AChE) DMEO794 MT DTT DMEO794 MA Inhibitor DMEO794 RN [From symptomatic to disease modifying therapy Recent developments in the pharmacotherapy of Alzheimer's disease]. Fortschr Neurol Psychiatr. 2009 Jun;77(6):326-33. DMEO794 RU https://pubmed.ncbi.nlm.nih.gov/19504422 DMEO794 DI DMEO794 DMEO794 DN Galantamine DMEO794 MI DECB0K3 DMEO794 MN Cytochrome P450 2D6 (CYP2D6) DMEO794 MT DME DMEO794 MA Metabolism DMEO794 RN Clinical pharmacokinetics of galantamine. Clin Pharmacokinet. 2003;42(15):1383-92. DMEO794 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=14674789 DMEO794 DI DMEO794 DMEO794 DN Galantamine DMEO794 MI DE4LYSA DMEO794 MN Cytochrome P450 3A4 (CYP3A4) DMEO794 MT DME DMEO794 MA Metabolism DMEO794 RN Clinical pharmacokinetics of galantamine. Clin Pharmacokinet. 2003;42(15):1383-92. DMEO794 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=14674789 DMIZ1E8 DI DMIZ1E8 DMIZ1E8 DN Galcanezumab DMIZ1E8 MI TTY6O0Q DMIZ1E8 MN Calcitonin gene-related peptide receptor (CGRPR) DMIZ1E8 MT DTT DMIZ1E8 MA Modulator DMIZ1E8 RN 2018 FDA drug approvals.Nat Rev Drug Discov. 2019 Feb;18(2):85-89. DMIZ1E8 RU https://pubmed.ncbi.nlm.nih.gov/30710142 DMPO0MS DI DMPO0MS DMPO0MS DN Gallamine Triethiodide DMPO0MS MI TTYEG6Q DMPO0MS MN Muscarinic acetylcholine receptor M2 (CHRM2) DMPO0MS MT DTT DMPO0MS MA Antagonist DMPO0MS RN Cholinergic regulation of the corpora allata in adult male loreyi leafworm Mythimna loreyi. Arch Insect Biochem Physiol. 2002 Apr;49(4):215-24. DMPO0MS RU https://pubmed.ncbi.nlm.nih.gov/11921079 DMF9O6B DI DMF9O6B DMF9O6B DN Gallium nitrate DMF9O6B MI TTRYK0X DMF9O6B MN Interleukin-1 beta (IL1B) DMF9O6B MT DTT DMF9O6B MA Inhibitor DMF9O6B RN Elimination of arthritis pain and inflammation for over 2 years with a single 90 min, topical 14% gallium nitrate treatment: case reports and revie... Med Hypotheses. 2005;65(6):1136-41. DMF9O6B RU https://pubmed.ncbi.nlm.nih.gov/16122880 DMER9YA DI DMER9YA DMER9YA DN Galsulfase DMER9YA MI TTESQTG DMER9YA MN N-acetylgalactosamine-4-sulfatase (G4S) DMER9YA MT DTT DMER9YA MA Modulator DMER9YA RN Enzyme replacement therapy for mucopolysaccharidosis VI: long-term cardiac effects of galsulfase (Naglazyme ) therapy. J Inherit Metab Dis. 2013 Mar;36(2):385-94. DMER9YA RU https://pubmed.ncbi.nlm.nih.gov/22669363 DMGBKVD DI DMGBKVD DMGBKVD DN Gamma hydroxybutyric acid DMGBKVD MI TTDCVZW DMGBKVD MN Gamma-aminobutyric acid B receptor (GABBR) DMGBKVD MT DTT DMGBKVD MA Modulator DMGBKVD RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. DMGBKVD RU https://www.fda.gov/ DMGBKVD DI DMGBKVD DMGBKVD DN Gamma hydroxybutyric acid DMGBKVD MI DT342ZG DMGBKVD MN Monocarboxylate transporter 1 (SLC16A1) DMGBKVD MT DTP DMGBKVD MA Substrate DMGBKVD RN Flavonoids modulate monocarboxylate transporter-1-mediated transport of gamma-hydroxybutyrate in vitro and in vivo. Drug Metab Dispos. 2007 Feb;35(2):201-8. DMGBKVD RU http://www.ncbi.nlm.nih.gov/pubmed/17108059 DMGBKVD DI DMGBKVD DMGBKVD DN Gamma hydroxybutyric acid DMGBKVD MI DTM301H DMGBKVD MN Sodium-coupled monocarboxylate transporter 2 (SLC5A12) DMGBKVD MT DTP DMGBKVD MA Substrate DMGBKVD RN Sodium-coupled monocarboxylate transporters in normal tissues and in cancer. AAPS J. 2008;10(1):193-9. DMGBKVD RU http://www.ncbi.nlm.nih.gov/pubmed/18446519 DMSXKYG DI DMSXKYG DMSXKYG DN Gamma-homolinolenic acid DMSXKYG MI TT8NGED DMSXKYG MN Prostaglandin G/H synthase 1 (COX-1) DMSXKYG MT DTT DMSXKYG MA Inhibitor DMSXKYG RN Differential metabolism of dihomo-gamma-linolenic acid and arachidonic acid by cyclo-oxygenase-1 and cyclo-oxygenase-2: implications for cellular synthesis of prostaglandin E1 and prostaglandin E2. Biochem J. 2002 Jul 15;365(Pt 2):489-96. DMSXKYG RU https://pubmed.ncbi.nlm.nih.gov/11939906 DMSXKYG DI DMSXKYG DMSXKYG DN Gamma-homolinolenic acid DMSXKYG MI DE073H6 DMSXKYG MN Prostaglandin G/H synthase 1 (COX-1) DMSXKYG MT DME DMSXKYG MA Metabolism DMSXKYG RN Divergent cyclooxygenase responses to fatty acid structure and peroxide level in fish and mammalian prostaglandin H synthases. FASEB J. 2006 Jun;20(8):1097-108. DMSXKYG RU https://www.ncbi.nlm.nih.gov/pubmed/?term=16770009 DMSXKYG DI DMSXKYG DMSXKYG DN Gamma-homolinolenic acid DMSXKYG MI DE492CE DMSXKYG MN Prostaglandin G/H synthase 2 (COX-2) DMSXKYG MT DME DMSXKYG MA Metabolism DMSXKYG RN Divergent cyclooxygenase responses to fatty acid structure and peroxide level in fish and mammalian prostaglandin H synthases. FASEB J. 2006 Jun;20(8):1097-108. DMSXKYG RU https://www.ncbi.nlm.nih.gov/pubmed/?term=16770009 DMQN30Z DI DMQN30Z DMQN30Z DN Gamolenic acid DMQN30Z MI DE073H6 DMQN30Z MN Prostaglandin G/H synthase 1 (COX-1) DMQN30Z MT DME DMQN30Z MA Metabolism DMQN30Z RN Divergent cyclooxygenase responses to fatty acid structure and peroxide level in fish and mammalian prostaglandin H synthases. FASEB J. 2006 Jun;20(8):1097-108. DMQN30Z RU https://www.ncbi.nlm.nih.gov/pubmed/?term=16770009 DMQN30Z DI DMQN30Z DMQN30Z DN Gamolenic acid DMQN30Z MI DE492CE DMQN30Z MN Prostaglandin G/H synthase 2 (COX-2) DMQN30Z MT DME DMQN30Z MA Metabolism DMQN30Z RN Divergent cyclooxygenase responses to fatty acid structure and peroxide level in fish and mammalian prostaglandin H synthases. FASEB J. 2006 Jun;20(8):1097-108. DMQN30Z RU https://www.ncbi.nlm.nih.gov/pubmed/?term=16770009 DM1MBYQ DI DM1MBYQ DM1MBYQ DN Ganciclovir DM1MBYQ MI DTW7AE3 DM1MBYQ MN Alanine/serine/cysteine/threonine transporter 2 (SLC1A5) DM1MBYQ MT DTP DM1MBYQ MA Substrate DM1MBYQ RN Amino Acid Transporter ATB0,+ as a delivery system for drugs and prodrugs. Curr Drug Targets Immune Endocr Metabol Disord. 2005 Dec;5(4):357-64. DM1MBYQ RU http://www.ncbi.nlm.nih.gov/pubmed/16375689 DM1MBYQ DI DM1MBYQ DM1MBYQ DN Ganciclovir DM1MBYQ MI DTI7UX6 DM1MBYQ MN Breast cancer resistance protein (ABCG2) DM1MBYQ MT DTP DM1MBYQ MA Substrate DM1MBYQ RN Side populations of glioblastoma cells are less sensitive to HSV-TK/GCV suicide gene therapy system than the non-side population. In Vitro Cell Dev Biol Anim. 2010 Jun;46(6):497-501. DM1MBYQ RU http://www.ncbi.nlm.nih.gov/pubmed/20135358 DM1MBYQ DI DM1MBYQ DM1MBYQ DN Ganciclovir DM1MBYQ MI TTIU7X1 DM1MBYQ MN Herpes simplex virus DNA polymerase UL30 (HSV UL30) DM1MBYQ MT DTT DM1MBYQ MA Inhibitor DM1MBYQ RN Application of real time polymerase chain reaction to the diagnosis and treatment of cytomegalovirus infection after allogeneic hematopoietic stem cell transplantation. Zhonghua Xue Ye Xue Za Zhi. 2009 Feb;30(2):77-81. DM1MBYQ RU https://pubmed.ncbi.nlm.nih.gov/19563015 DM1MBYQ DI DM1MBYQ DM1MBYQ DN Ganciclovir DM1MBYQ MI DTZGT0P DM1MBYQ MN Multidrug and toxin extrusion protein 1 (SLC47A1) DM1MBYQ MT DTP DM1MBYQ MA Substrate DM1MBYQ RN Substrate specificity of MATE1 and MATE2-K, human multidrug and toxin extrusions/H(+)-organic cation antiporters. Biochem Pharmacol. 2007 Jul 15;74(2):359-71. DM1MBYQ RU http://www.ncbi.nlm.nih.gov/pubmed/17509534 DM1MBYQ DI DM1MBYQ DM1MBYQ DN Ganciclovir DM1MBYQ MI DT3TX4H DM1MBYQ MN Multidrug and toxin extrusion protein 2 (SLC47A2) DM1MBYQ MT DTP DM1MBYQ MA Substrate DM1MBYQ RN Substrate specificity of MATE1 and MATE2-K, human multidrug and toxin extrusions/H(+)-organic cation antiporters. Biochem Pharmacol. 2007 Jul 15;74(2):359-71. DM1MBYQ RU http://www.ncbi.nlm.nih.gov/pubmed/17509534 DM1MBYQ DI DM1MBYQ DM1MBYQ DN Ganciclovir DM1MBYQ MI DTCSGPB DM1MBYQ MN Multidrug resistance-associated protein 4 (ABCC4) DM1MBYQ MT DTP DM1MBYQ MA Substrate DM1MBYQ RN Human intestinal transporter database: QSAR modeling and virtual profiling of drug uptake, efflux and interactions. Pharm Res. 2013 Apr;30(4):996-1007. DM1MBYQ RU https://doi.org/10.1007/s11095-012-0935-x DM1MBYQ DI DM1MBYQ DM1MBYQ DN Ganciclovir DM1MBYQ MI DTYVM24 DM1MBYQ MN Multidrug resistance-associated protein 5 (ABCC5) DM1MBYQ MT DTP DM1MBYQ MA Substrate DM1MBYQ RN Cellular export of drugs and signaling molecules by the ATP-binding cassette transporters MRP4 (ABCC4) and MRP5 (ABCC5). Drug Metab Rev. 2005;37(1):253-78. DM1MBYQ RU http://www.ncbi.nlm.nih.gov/pubmed/15747503 DM1MBYQ DI DM1MBYQ DM1MBYQ DN Ganciclovir DM1MBYQ MI DTQ23VB DM1MBYQ MN Organic anion transporter 1 (SLC22A6) DM1MBYQ MT DTP DM1MBYQ MA Substrate DM1MBYQ RN Human organic anion transporters and human organic cation transporters mediate renal antiviral transport. J Pharmacol Exp Ther. 2002 Mar;300(3):918-24. DM1MBYQ RU http://www.ncbi.nlm.nih.gov/pubmed/11861798 DM1MBYQ DI DM1MBYQ DM1MBYQ DN Ganciclovir DM1MBYQ MI DTVP67E DM1MBYQ MN Organic anion transporter 3 (SLC22A8) DM1MBYQ MT DTP DM1MBYQ MA Substrate DM1MBYQ RN FDA Drug Development and Drug Interactions DM1MBYQ RU https://www.fda.gov/drugs/developmentapprovalprocess/developmentresources/druginteractionslabeling/ucm093664.htm#table3-2 DM1MBYQ DI DM1MBYQ DM1MBYQ DN Ganciclovir DM1MBYQ MI DTT79CX DM1MBYQ MN Organic cation transporter 1 (SLC22A1) DM1MBYQ MT DTP DM1MBYQ MA Substrate DM1MBYQ RN Human organic anion transporters and human organic cation transporters mediate renal antiviral transport. J Pharmacol Exp Ther. 2002 Mar;300(3):918-24. DM1MBYQ RU http://www.ncbi.nlm.nih.gov/pubmed/11861798 DMGMB30 DI DMGMB30 DMGMB30 DN Ganirelix DMGMB30 MI TT8R70G DMGMB30 MN Gonadotropin-releasing hormone receptor (GNRHR) DMGMB30 MT DTT DMGMB30 MA Antagonist DMGMB30 RN Age attenuates testosterone secretion driven by amplitude-varying pulses of recombinant human luteinizing hormone during acute gonadotrope inhibiti... J Clin Endocrinol Metab. 2007 Sep;92(9):3626-32. DMGMB30 RU https://pubmed.ncbi.nlm.nih.gov/17579202 DMSL679 DI DMSL679 DMSL679 DN Gatifloxacin DMSL679 MI TTN6J5F DMSL679 MN Bacterial DNA gyrase (Bact gyrase) DMSL679 MT DTT DMSL679 MA Modulator DMSL679 RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. DMSL679 RU https://www.fda.gov/ DMSL679 DI DMSL679 DMSL679 DN Gatifloxacin DMSL679 MI DTFI42L DMSL679 MN Multidrug resistance-associated protein 2 (ABCC2) DMSL679 MT DTP DMSL679 MA Substrate DMSL679 RN Uptake and intracellular release kinetics of liposome formulations in glioma cells. Int J Pharm. 2010 Aug 16;395(1-2):251-9. DMSL679 RU http://www.ncbi.nlm.nih.gov/pubmed/20573571 DMSL679 DI DMSL679 DMSL679 DN Gatifloxacin DMSL679 MI DTE2B1D DMSL679 MN Organic anion transporting polypeptide 1A2 (SLCO1A2) DMSL679 MT DTP DMSL679 MA Substrate DMSL679 RN Identification of influx transporter for the quinolone antibacterial agent levofloxacin. Mol Pharm. 2007 Jan-Feb;4(1):85-94. DMSL679 RU http://www.ncbi.nlm.nih.gov/pubmed/17274666 DMSL679 DI DMSL679 DMSL679 DN Gatifloxacin DMSL679 MI DTUGYRD DMSL679 MN P-glycoprotein 1 (ABCB1) DMSL679 MT DTP DMSL679 MA Substrate DMSL679 RN Interaction of gatifloxacin with efflux transporters: a possible mechanism for drug resistance. Int J Pharm. 2010 Aug 16;395(1-2):114-21. DMSL679 RU http://www.ncbi.nlm.nih.gov/pubmed/20573570 DMSL679 DI DMSL679 DMSL679 DN Gatifloxacin DMSL679 MI TTIXTO3 DMSL679 MN Staphylococcus Topoisomerase IV (Stap-coc parC) DMSL679 MT DTT DMSL679 MA Modulator DMSL679 RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. DMSL679 RU https://www.fda.gov/ DMH0QKA DI DMH0QKA DMH0QKA DN GDC-0199 DMH0QKA MI TTJGNVC DMH0QKA MN Apoptosis regulator Bcl-2 (BCL-2) DMH0QKA MT DTT DMH0QKA MA Modulator DMH0QKA RN ABT-199, a potent and selective BCL-2 inhibitor, achieves antitumor activity while sparing platelets. Nat Med. 2013 Feb;19(2):202-8. DMH0QKA RU https://pubmed.ncbi.nlm.nih.gov/23291630 DM15F0X DI DM15F0X DM15F0X DN Gefitinib DM15F0X MI DTI7UX6 DM15F0X MN Breast cancer resistance protein (ABCG2) DM15F0X MT DTP DM15F0X MA Substrate DM15F0X RN Mammalian drug efflux transporters of the ATP binding cassette (ABC) family in multidrug resistance: A review of the past decade. Cancer Lett. 2016 Jan 1;370(1):153-64. DM15F0X RU http://www.ncbi.nlm.nih.gov/pubmed/26499806 DM15F0X DI DM15F0X DM15F0X DN Gefitinib DM15F0X MI DECB0K3 DM15F0X MN Cytochrome P450 2D6 (CYP2D6) DM15F0X MT DME DM15F0X MA Metabolism DM15F0X RN Pharmacokinetic drug interactions of gefitinib with rifampicin, itraconazole and metoprolol. Clin Pharmacokinet. 2005;44(10):1067-81. DM15F0X RU https://www.ncbi.nlm.nih.gov/pubmed/?term=16176119 DM15F0X DI DM15F0X DM15F0X DN Gefitinib DM15F0X MI DE4LYSA DM15F0X MN Cytochrome P450 3A4 (CYP3A4) DM15F0X MT DME DM15F0X MA Metabolism DM15F0X RN Differential metabolism of gefitinib and erlotinib by human cytochrome P450 enzymes. Clin Cancer Res. 2007 Jun 15;13(12):3731-7. DM15F0X RU https://www.ncbi.nlm.nih.gov/pubmed/?term=17575239 DM15F0X DI DM15F0X DM15F0X DN Gefitinib DM15F0X MI DEIBDNY DM15F0X MN Cytochrome P450 3A5 (CYP3A5) DM15F0X MT DME DM15F0X MA Metabolism DM15F0X RN Differential metabolism of gefitinib and erlotinib by human cytochrome P450 enzymes. Clin Cancer Res. 2007 Jun 15;13(12):3731-7. DM15F0X RU https://www.ncbi.nlm.nih.gov/pubmed/?term=17575239 DM15F0X DI DM15F0X DM15F0X DN Gefitinib DM15F0X MI TTGKNB4 DM15F0X MN Epidermal growth factor receptor (EGFR) DM15F0X MT DTT DM15F0X MA Inhibitor DM15F0X RN Gefitinib ('Iressa', ZD1839) and new epidermal growth factor receptor inhibitors. Br J Cancer. 2004 Feb 9;90(3):566-72. DM15F0X RU https://pubmed.ncbi.nlm.nih.gov/14760365 DM15F0X DI DM15F0X DM15F0X DN Gefitinib DM15F0X MI DT3D8F0 DM15F0X MN Organic anion transporting polypeptide 1B1 (SLCO1B1) DM15F0X MT DTP DM15F0X MA Substrate DM15F0X RN Contribution of OATP1B1 and OATP1B3 to the disposition of sorafenib and sorafenib-glucuronide. Clin Cancer Res. 2013 Mar 15;19(6):1458-66. DM15F0X RU http://www.ncbi.nlm.nih.gov/pubmed/23340295 DM15F0X DI DM15F0X DM15F0X DN Gefitinib DM15F0X MI DT9C1TS DM15F0X MN Organic anion transporting polypeptide 1B3 (SLCO1B3) DM15F0X MT DTP DM15F0X MA Substrate DM15F0X RN Contribution of OATP1B1 and OATP1B3 to the disposition of sorafenib and sorafenib-glucuronide. Clin Cancer Res. 2013 Mar 15;19(6):1458-66. DM15F0X RU http://www.ncbi.nlm.nih.gov/pubmed/23340295 DM15F0X DI DM15F0X DM15F0X DN Gefitinib DM15F0X MI DTUGYRD DM15F0X MN P-glycoprotein 1 (ABCB1) DM15F0X MT DTP DM15F0X MA Substrate DM15F0X RN Gefitinib-phenytoin interaction is not correlated with the C-erythromycin breath test in healthy male volunteers. Br J Clin Pharmacol. 2009 Aug;68(2):226-37. DM15F0X RU http://www.ncbi.nlm.nih.gov/pubmed/19694743 DMSE3I7 DI DMSE3I7 DMSE3I7 DN Gemcitabine DMSE3I7 MI DT0EQPW DMSE3I7 MN Concentrative nucleoside transporter 1 (SLC28A1) DMSE3I7 MT DTP DMSE3I7 MA Substrate DMSE3I7 RN Pancreatic Cancer Chemoresistance to Gemcitabine. Cancers (Basel). 2017 Nov 16;9(11). DMSE3I7 RU http://www.ncbi.nlm.nih.gov/pubmed/29144412 DMSE3I7 DI DMSE3I7 DMSE3I7 DN Gemcitabine DMSE3I7 MI DEKEDRC DMSE3I7 MN Cytidine aminohydrolase (CDA) DMSE3I7 MT DME DMSE3I7 MA Metabolism DMSE3I7 RN Equilibrative nucleoside transporter 1 genotype, cytidine deaminase activity and age predict gemcitabine plasma clearance in patients with solid tumours. Br J Clin Pharmacol. 2011 Mar;71(3):437-44. DMSE3I7 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=21284703 DMSE3I7 DI DMSE3I7 DMSE3I7 DN Gemcitabine DMSE3I7 MI DETX3A5 DMSE3I7 MN Cytidine deaminase (cdd) DMSE3I7 MT DME DMSE3I7 MA Metabolism DMSE3I7 RN Potential role of intratumor bacteria in mediating tumor resistance to the chemotherapeutic drug gemcitabine. Science. 2017 Sep 15;357(6356):1156-1160. DMSE3I7 RU https://pubmed.ncbi.nlm.nih.gov/28912244 DMSE3I7 DI DMSE3I7 DMSE3I7 DN Gemcitabine DMSE3I7 MI DEFVABT DMSE3I7 MN Cytidine deaminase (cdd) DMSE3I7 MT DME DMSE3I7 MA Metabolism DMSE3I7 RN Potential role of intratumor bacteria in mediating tumor resistance to the chemotherapeutic drug gemcitabine. Science. 2017 Sep 15;357(6356):1156-1160. DMSE3I7 RU https://pubmed.ncbi.nlm.nih.gov/28912244 DMSE3I7 DI DMSE3I7 DMSE3I7 DN Gemcitabine DMSE3I7 MI DEYILK4 DMSE3I7 MN Cytidine deaminase (cdd) DMSE3I7 MT DME DMSE3I7 MA Metabolism DMSE3I7 RN Mycoplasma hyorhinis-encoded cytidine deaminase efficiently inactivates cytosine-based anticancer drugs. FEBS Open Bio. 2015 Aug 3;5:634-9. DMSE3I7 RU https://pubmed.ncbi.nlm.nih.gov/26322268 DMSE3I7 DI DMSE3I7 DMSE3I7 DN Gemcitabine DMSE3I7 MI DTYVM24 DMSE3I7 MN Multidrug resistance-associated protein 5 (ABCC5) DMSE3I7 MT DTP DMSE3I7 MA Substrate DMSE3I7 RN Interdependence of gemcitabine treatment, transporter expression, and resistance in human pancreatic carcinoma cells. Neoplasia. 2010 Sep;12(9):740-7. DMSE3I7 RU http://www.ncbi.nlm.nih.gov/pubmed/20824050 DMSE3I7 DI DMSE3I7 DMSE3I7 DN Gemcitabine DMSE3I7 MI DTUGYRD DMSE3I7 MN P-glycoprotein 1 (ABCB1) DMSE3I7 MT DTP DMSE3I7 MA Substrate DMSE3I7 RN Increased sensitivity to gemcitabine of P-glycoprotein and multidrug resistance-associated protein-overexpressing human cancer cell lines. Br J Cancer. 2003 Jun 16;88(12):1963-70. DMSE3I7 RU https://doi.org/10.1038/sj.bjc.6601011 DMSE3I7 DI DMSE3I7 DMSE3I7 DN Gemcitabine DMSE3I7 MI TTBWDI0 DMSE3I7 MN Ribonucleoside-diphosphate reductase M2 (RRM2) DMSE3I7 MT DTT DMSE3I7 MA Modulator DMSE3I7 RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. DMSE3I7 RU https://www.fda.gov/ DMSE3I7 DI DMSE3I7 DMSE3I7 DN Gemcitabine DMSE3I7 MI DEMPH4I DMSE3I7 MN Uridine/cytidine monophosphate kinase (UMPK) DMSE3I7 MT DME DMSE3I7 MA Metabolism DMSE3I7 RN Gemcitabine pharmacogenomics: deoxycytidine kinase and cytidylate kinase gene resequencing and functional genomics. Drug Metab Dispos. 2008 Sep;36(9):1951-9. DMSE3I7 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=18556440 DMD8Q3J DI DMD8Q3J DMD8Q3J DN Gemfibrozil DMD8Q3J MI DEFKSVZ DMD8Q3J MN Catechol-2,3-dioxygenase (caD) DMD8Q3J MT DME DMD8Q3J MA Metabolism DMD8Q3J RN Genomic, proteomic, and metabolite characterization of gemfibrozil-degrading organism Bacillus sp. GeD10. Environ Sci Technol. 2016 Jan 19;50(2):744-55. DMD8Q3J RU https://pubmed.ncbi.nlm.nih.gov/26683816 DMD8Q3J DI DMD8Q3J DMD8Q3J DN Gemfibrozil DMD8Q3J MI DE4LYSA DMD8Q3J MN Cytochrome P450 3A4 (CYP3A4) DMD8Q3J MT DME DMD8Q3J MA Metabolism DMD8Q3J RN Clinical pharmacokinetics of fibric acid derivatives (fibrates). Clin Pharmacokinet. 1998 Feb;34(2):155-62. DMD8Q3J RU https://www.ncbi.nlm.nih.gov/pubmed/?term=9515185 DMD8Q3J DI DMD8Q3J DMD8Q3J DN Gemfibrozil DMD8Q3J MI TTOF3WZ DMD8Q3J MN Lipoprotein lipase (LPL) DMD8Q3J MT DTT DMD8Q3J MA Activator DMD8Q3J RN Mode of action of fibrates in the regulation of triglyceride and HDL-cholesterol metabolism. Drugs Today (Barc). 2006 Jan;42(1):39-64. DMD8Q3J RU https://pubmed.ncbi.nlm.nih.gov/16511610 DMD8Q3J DI DMD8Q3J DMD8Q3J DN Gemfibrozil DMD8Q3J MI DEYGVN4 DMD8Q3J MN UDP-glucuronosyltransferase 1A1 (UGT1A1) DMD8Q3J MT DME DMD8Q3J MA Metabolism DMD8Q3J RN The UDP-glucuronosyltransferase 2B7 isozyme is responsible for gemfibrozil glucuronidation in the human liver. Drug Metab Dispos. 2007 Nov;35(11):2040-4. DMD8Q3J RU https://www.ncbi.nlm.nih.gov/pubmed/?term=17670842 DMD8Q3J DI DMD8Q3J DMD8Q3J DN Gemfibrozil DMD8Q3J MI DEF2WXN DMD8Q3J MN UDP-glucuronosyltransferase 1A3 (UGT1A3) DMD8Q3J MT DME DMD8Q3J MA Metabolism DMD8Q3J RN Comprehensive pharmacogenomic study reveals an important role of UGT1A3 in montelukast pharmacokinetics. Clin Pharmacol Ther. 2018 Jul;104(1):158-168. DMD8Q3J RU https://www.ncbi.nlm.nih.gov/pubmed/?term=28940478 DMD8Q3J DI DMD8Q3J DMD8Q3J DN Gemfibrozil DMD8Q3J MI DE85D2P DMD8Q3J MN UDP-glucuronosyltransferase 1A9 (UGT1A9) DMD8Q3J MT DME DMD8Q3J MA Metabolism DMD8Q3J RN The UDP-glucuronosyltransferase 2B7 isozyme is responsible for gemfibrozil glucuronidation in the human liver. Drug Metab Dispos. 2007 Nov;35(11):2040-4. DMD8Q3J RU https://www.ncbi.nlm.nih.gov/pubmed/?term=17670842 DMD8Q3J DI DMD8Q3J DMD8Q3J DN Gemfibrozil DMD8Q3J MI DEB3CV1 DMD8Q3J MN UDP-glucuronosyltransferase 2B7 (UGT2B7) DMD8Q3J MT DME DMD8Q3J MA Metabolism DMD8Q3J RN The UDP-glucuronosyltransferase 2B7 isozyme is responsible for gemfibrozil glucuronidation in the human liver. Drug Metab Dispos. 2007 Nov;35(11):2040-4. DMD8Q3J RU https://www.ncbi.nlm.nih.gov/pubmed/?term=17670842 DMHT34O DI DMHT34O DMHT34O DN Gemifloxacin DMHT34O MI TTN6J5F DMHT34O MN Bacterial DNA gyrase (Bact gyrase) DMHT34O MT DTT DMHT34O MA Modulator DMHT34O RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. DMHT34O RU https://www.fda.gov/ DMHT34O DI DMHT34O DMHT34O DN Gemifloxacin DMHT34O MI DTFI42L DMHT34O MN Multidrug resistance-associated protein 2 (ABCC2) DMHT34O MT DTP DMHT34O MA Substrate DMHT34O RN Differential effect of P-gp and MRP2 on cellular translocation of gemifloxacin. Int J Pharm. 2011 Nov 25;420(1):26-33. DMHT34O RU http://www.ncbi.nlm.nih.gov/pubmed/21864659 DMHT34O DI DMHT34O DMHT34O DN Gemifloxacin DMHT34O MI TTIXTO3 DMHT34O MN Staphylococcus Topoisomerase IV (Stap-coc parC) DMHT34O MT DTT DMHT34O MA Modulator DMHT34O RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. DMHT34O RU https://www.fda.gov/ DMJ2O7B DI DMJ2O7B DMJ2O7B DN Gemtuzumab ozogamicin DMJ2O7B MI DE4LYSA DMJ2O7B MN Cytochrome P450 3A4 (CYP3A4) DMJ2O7B MT DME DMJ2O7B MA Metabolism DMJ2O7B RN Clinical pharmacokinetics of fibric acid derivatives (fibrates). Clin Pharmacokinet. 1998 Feb;34(2):155-62. DMJ2O7B RU https://www.ncbi.nlm.nih.gov/pubmed/?term=9515185 DMJ2O7B DI DMJ2O7B DMJ2O7B DN Gemtuzumab ozogamicin DMJ2O7B MI TTJVYO3 DMJ2O7B MN Myeloid cell surface antigen CD33 (CD33) DMJ2O7B MT DTT DMJ2O7B RN Targeted treatment of acute myeloid leukemia in older adults: role of gemtuzumab ozogamicin. Clin Interv Aging. 2009;4:197-205. DMJ2O7B RU https://pubmed.ncbi.nlm.nih.gov/19503782 DMKINJO DI DMKINJO DMKINJO DN Gentamicin DMKINJO MI DE48UAX DMKINJO MN Aminoglycoside 6'-N-acetyltransferase (aacA) DMKINJO MT DME DMKINJO MA Metabolism DMKINJO RN Detection of multidrug-resistant Enterobacteriaceae isolated from river waters flowing to the Guanabara Bay and from clinical samples of hospitals in Rio de Janeiro, Brazil. Biomedica. 2019 May 1;39(s1):135-149. DMKINJO RU https://pubmed.ncbi.nlm.nih.gov/31529856 DMKINJO DI DMKINJO DMKINJO DN Gentamicin DMKINJO MI DEWPAJD DMKINJO MN Aminoglycoside O-phosphotransferase (aphA6) DMKINJO MT DME DMKINJO MA Metabolism DMKINJO RN Relationship between antimicrobial resistance and aminoglycoside-modifying enzyme gene expressions in Acinetobacter baumannii. Chin Med J (Engl). 2005 Jan 20;118(2):141-5. DMKINJO RU https://pubmed.ncbi.nlm.nih.gov/15667800 DMKINJO DI DMKINJO DMKINJO DN Gentamicin DMKINJO MI DE5WGIM DMKINJO MN Aminoglycoside phosphotransferase (aph-Ib) DMKINJO MT DME DMKINJO MA Metabolism DMKINJO RN Cloning and expression of novel aminoglycoside phosphotransferase genes from Campylobacter and their role in the resistance to six aminoglycosides. Antimicrob Agents Chemother. 2017 Dec 21;62(1). pii: e01682-17. DMKINJO RU https://pubmed.ncbi.nlm.nih.gov/29109167 DMKINJO DI DMKINJO DMKINJO DN Gentamicin DMKINJO MI TTOVFH2 DMKINJO MN Bacterial 30S ribosomal RNA (Bact 30S rRNA) DMKINJO MT DTT DMKINJO MA Modulator DMKINJO RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. DMKINJO RU https://www.fda.gov/ DMKINJO DI DMKINJO DMKINJO DN Gentamicin DMKINJO MI DE2M583 DMKINJO MN Endoglucanase Y (EGY) DMKINJO MT DME DMKINJO MA Metabolism DMKINJO RN Expression of Clostridium thermocellum endoglucanase gene in Lactobacillus gasseri and Lactobacillus johnsonii and characterization of the genetically modified probiotic lactobacilli. Curr Microbiol. 2000 Apr;40(4):257-63. DMKINJO RU https://pubmed.ncbi.nlm.nih.gov/10688695 DMKINJO DI DMKINJO DMKINJO DN Gentamicin DMKINJO MI DE2AZTG DMKINJO MN Endoglucanase Y (EGY) DMKINJO MT DME DMKINJO MA Metabolism DMKINJO RN Expression of Clostridium thermocellum endoglucanase gene in Lactobacillus gasseri and Lactobacillus johnsonii and characterization of the genetically modified probiotic lactobacilli. Curr Microbiol. 2000 Apr;40(4):257-63. DMKINJO RU https://pubmed.ncbi.nlm.nih.gov/10688695 DMKINJO DI DMKINJO DMKINJO DN Gentamicin DMKINJO MI DECXWN8 DMKINJO MN Kanamycin/gentamycin-resistance enzyme (aacA) DMKINJO MT DME DMKINJO MA Metabolism DMKINJO RN Cloning and expression of novel aminoglycoside phosphotransferase genes from Campylobacter and their role in the resistance to six aminoglycosides. Antimicrob Agents Chemother. 2017 Dec 21;62(1). pii: e01682-17. DMKINJO RU https://pubmed.ncbi.nlm.nih.gov/29109167 DMBT7MI DI DMBT7MI DMBT7MI DN Gentamicine sulfate DMBT7MI MI TTUWYEA DMBT7MI MN Bacterial 50S ribosomal RNA (Bact 50S rRNA) DMBT7MI MT DTT DMBT7MI MA Binder DMBT7MI RN The protein synthesis inhibitors, oxazolidinones and chloramphenicol, cause extensive translational inaccuracy in vivo. J Mol Biol. 2002 Sep 13;322(2):273-9. DMBT7MI RU https://pubmed.ncbi.nlm.nih.gov/12217690 DMP0OVQ DI DMP0OVQ DMP0OVQ DN Gestrinone DMP0OVQ MI DE4LYSA DMP0OVQ MN Cytochrome P450 3A4 (CYP3A4) DMP0OVQ MT DME DMP0OVQ MA Metabolism DMP0OVQ RN Adverse drug interactions: a handbook for prescribers. Taylor and Francis group.2010. DMP0OVQ RU https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3040554/ DMP0OVQ DI DMP0OVQ DMP0OVQ DN Gestrinone DMP0OVQ MI TTZAYWL DMP0OVQ MN Estrogen receptor (ESR) DMP0OVQ MT DTT DMP0OVQ MA Modulator DMP0OVQ RN Natural products as sources of new drugs over the last 25 years. J Nat Prod. 2007 Mar;70(3):461-77. DMP0OVQ RU https://pubmed.ncbi.nlm.nih.gov/17309302 DMKGH0R DI DMKGH0R DMKGH0R DN GHRP-2 DMKGH0R MI TTWDC17 DMKGH0R MN Growth hormone secretagogue receptor 1 (GHSR) DMKGH0R MT DTT DMKGH0R MA Agonist DMKGH0R RN GH-releasing peptide-2 increases fat mass in mice lacking NPY: indication for a crucial mediating role of hypothalamic agouti-related protein. Endocrinology. 2002 Feb;143(2):558-68. DMKGH0R RU https://pubmed.ncbi.nlm.nih.gov/11796511 DMKGH0R DI DMKGH0R DMKGH0R DN GHRP-2 DMKGH0R MI TTZ3IFB DMKGH0R MN Phosphogluconate dehydrogenase (PGD) DMKGH0R MT DTT DMKGH0R MA Inhibitor DMKGH0R RN Synthesis and biological evaluation of substrate-based inhibitors of 6-phosphogluconate dehydrogenase as potential drugs against African trypanosomiasis. Bioorg Med Chem. 2003 Jul 17;11(14):3205-14. DMKGH0R RU https://pubmed.ncbi.nlm.nih.gov/12818683 DMWQ4MZ DI DMWQ4MZ DMWQ4MZ DN Gilteritinib DMWQ4MZ MI DE4LYSA DMWQ4MZ MN Cytochrome P450 3A4 (CYP3A4) DMWQ4MZ MT DME DMWQ4MZ MA Metabolism DMWQ4MZ RN ClinicalTrials.gov (NCT02456883) Study to Investigate the Absorption, Metabolism and Excretion of [14C] ASP2215 in Patients With Advanced Solid Tumors. DMWQ4MZ RU https://clinicaltrials.gov/ct2/show/NCT02456883 DMWQ4MZ DI DMWQ4MZ DMWQ4MZ DN Gilteritinib DMWQ4MZ MI TTGJCWZ DMWQ4MZ MN Fms-like tyrosine kinase 3 (FLT-3) DMWQ4MZ MT DTT DMWQ4MZ MA Inhibitor DMWQ4MZ RN 2018 FDA drug approvals.Nat Rev Drug Discov. 2019 Feb;18(2):85-89. DMWQ4MZ RU https://pubmed.ncbi.nlm.nih.gov/30710142 DMTI0ZO DI DMTI0ZO DMTI0ZO DN Gilteritinib DMTI0ZO MI DTUGYRD DMTI0ZO MN P-glycoprotein 1 (ABCB1) DMTI0ZO MT DTP DMTI0ZO MA Substrate DMTI0ZO RN KEGG: new perspectives on genomes, pathways, diseases and drugs. Nucleic Acids Res. 2017 Jan 4;45(D1):D353-D361. (dg:DG01665) DMTI0ZO RU https://www.kegg.jp/dbget-bin/www_bget?dg:DG01665 DMWQ4MZ DI DMWQ4MZ DMWQ4MZ DN Gilteritinib DMWQ4MZ MI TTZPY6J DMWQ4MZ MN Tyrosine-protein kinase UFO (AXL) DMWQ4MZ MT DTT DMWQ4MZ MA Inhibitor DMWQ4MZ RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMWQ4MZ RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DM5PFIJ DI DM5PFIJ DM5PFIJ DN Givosiran DM5PFIJ MI TTG1FXO DM5PFIJ MN ALAS1 messenger RNA (ALAS1 mRNA) DM5PFIJ MT DTT DM5PFIJ MA Inhibitor DM5PFIJ RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health Human Services. 2019 DM5PFIJ RU https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/0212194s000lbl.pdf DM83MOK DI DM83MOK DM83MOK DN Glassia DM83MOK MI TTA7UJC DM83MOK MN Alpha-1-antitrypsin (SERPINA1) DM83MOK MT DTT DM83MOK MA Inhibitor DM83MOK RN Mullard A: 2010 FDA drug approvals. Nat Rev Drug Discov. 2011 Feb;10(2):82-5. DM83MOK RU https://pubmed.ncbi.nlm.nih.gov/21283092 DMAPV1B DI DMAPV1B DMAPV1B DN Glatiramer acetate DMAPV1B MI TTLCMWF DMAPV1B MN MHC class II antigen DRB1*1 (HLA-DRB1) DMAPV1B MT DTT DMAPV1B MA Binder DMAPV1B RN Mechanism of action of glatiramer acetate in multiple sclerosis and its potential for the development of new applications. Proc Natl Acad Sci U S A. 2004 Oct 5;101 Suppl 2:14593-8. DMAPV1B RU https://pubmed.ncbi.nlm.nih.gov/15371592 DM31YVO DI DM31YVO DM31YVO DN Glecaprevir DM31YVO MI DE4LYSA DM31YVO MN Cytochrome P450 3A4 (CYP3A4) DM31YVO MT DME DM31YVO MA Metabolism DM31YVO RN The pharmacological interactions between direct-acting antivirals for the treatment of chronic hepatitis c and psychotropic drugs. Expert Rev Clin Pharmacol. 2018 Oct;11(10):999-1030. DM31YVO RU https://www.ncbi.nlm.nih.gov/pubmed/?term=30199279 DMF6Z5T DI DMF6Z5T DMF6Z5T DN Glecaprevir; pibrentasvir DMF6Z5T MI TTCJ2X8 DMF6Z5T MN Hepatitis C virus Non-structural 5A (HCV NS5A) DMF6Z5T MT DTT DMF6Z5T MA Inhibitor DMF6Z5T RN 2017 FDA drug approvals.Nat Rev Drug Discov. 2018 Feb;17(2):81-85. DMF6Z5T RU https://pubmed.ncbi.nlm.nih.gov/29348678 DMF6Z5T DI DMF6Z5T DMF6Z5T DN Glecaprevir; pibrentasvir DMF6Z5T MI TTHC7JD DMF6Z5T MN Hepatitis C virus Serine protease NS3/4A (HCV NS3/4A) DMF6Z5T MT DTT DMF6Z5T MA Inhibitor DMF6Z5T RN 2017 FDA drug approvals.Nat Rev Drug Discov. 2018 Feb;17(2):81-85. DMF6Z5T RU https://pubmed.ncbi.nlm.nih.gov/29348678 DM8JXPZ DI DM8JXPZ DM8JXPZ DN Glibenclamide DM8JXPZ MI TTP835K DM8JXPZ MN ATP-binding cassette transporter C8 (ABCC8) DM8JXPZ MT DTT DM8JXPZ MA Modulator DM8JXPZ RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. DM8JXPZ RU https://www.fda.gov/ DM8JXPZ DI DM8JXPZ DM8JXPZ DN Glibenclamide DM8JXPZ MI DTI7UX6 DM8JXPZ MN Breast cancer resistance protein (ABCG2) DM8JXPZ MT DTP DM8JXPZ MA Substrate DM8JXPZ RN Glyburide transport across the human placenta. Obstet Gynecol. 2015 Mar;125(3):583-8. DM8JXPZ RU http://www.ncbi.nlm.nih.gov/pubmed/25730219 DM8JXPZ DI DM8JXPZ DM8JXPZ DN Glibenclamide DM8JXPZ MI DE5IED8 DM8JXPZ MN Cytochrome P450 2C9 (CYP2C9) DM8JXPZ MT DME DM8JXPZ MA Metabolism DM8JXPZ RN Contributions of human cytochrome P450 enzymes to glyburide metabolism. Biopharm Drug Dispos. 2010 May;31(4):228-42. DM8JXPZ RU https://www.ncbi.nlm.nih.gov/pubmed/?term=20437462 DM8JXPZ DI DM8JXPZ DM8JXPZ DN Glibenclamide DM8JXPZ MI DE4LYSA DM8JXPZ MN Cytochrome P450 3A4 (CYP3A4) DM8JXPZ MT DME DM8JXPZ MA Metabolism DM8JXPZ RN Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. DM8JXPZ RU https://www.ncbi.nlm.nih.gov/pubmed/?term=19515014 DM8JXPZ DI DM8JXPZ DM8JXPZ DN Glibenclamide DM8JXPZ MI DEIBDNY DM8JXPZ MN Cytochrome P450 3A5 (CYP3A5) DM8JXPZ MT DME DM8JXPZ MA Metabolism DM8JXPZ RN Identification of CYP3A7 for glyburide metabolism in human fetal livers. Biochem Pharmacol. 2014 Dec 15;92(4):690-700. DM8JXPZ RU https://www.ncbi.nlm.nih.gov/pubmed/?term=25450675 DM8JXPZ DI DM8JXPZ DM8JXPZ DN Glibenclamide DM8JXPZ MI DERD86B DM8JXPZ MN Cytochrome P450 3A7 (CYP3A7) DM8JXPZ MT DME DM8JXPZ MA Metabolism DM8JXPZ RN Identification of CYP3A7 for glyburide metabolism in human fetal livers. Biochem Pharmacol. 2014 Dec 15;92(4):690-700. DM8JXPZ RU https://www.ncbi.nlm.nih.gov/pubmed/?term=25450675 DM8JXPZ DI DM8JXPZ DM8JXPZ DN Glibenclamide DM8JXPZ MI DEGTFWK DM8JXPZ MN Mephenytoin 4-hydroxylase (CYP2C19) DM8JXPZ MT DME DM8JXPZ MA Metabolism DM8JXPZ RN Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. DM8JXPZ RU https://www.ncbi.nlm.nih.gov/pubmed/?term=19515014 DM8JXPZ DI DM8JXPZ DM8JXPZ DN Glibenclamide DM8JXPZ MI DTQ3ZHF DM8JXPZ MN Multidrug resistance-associated protein 3 (ABCC3) DM8JXPZ MT DTP DM8JXPZ MA Substrate DM8JXPZ RN Transport of glyburide by placental ABC transporters: implications in fetal drug exposure. Placenta. 2006 Nov-Dec;27(11-12):1096-102. DM8JXPZ RU http://www.ncbi.nlm.nih.gov/pubmed/16460798 DM8JXPZ DI DM8JXPZ DM8JXPZ DN Glibenclamide DM8JXPZ MI DTPFTEQ DM8JXPZ MN Organic anion transporting polypeptide 2B1 (SLCO2B1) DM8JXPZ MT DTP DM8JXPZ MA Substrate DM8JXPZ RN Citrus juices inhibit the function of human organic anion-transporting polypeptide OATP-B. Drug Metab Dispos. 2005 Apr;33(4):518-23. DM8JXPZ RU http://www.ncbi.nlm.nih.gov/pubmed/15640378 DM8JXPZ DI DM8JXPZ DM8JXPZ DN Glibenclamide DM8JXPZ MI DEYGVN4 DM8JXPZ MN UDP-glucuronosyltransferase 1A1 (UGT1A1) DM8JXPZ MT DME DM8JXPZ MA Metabolism DM8JXPZ RN Contribution of UDP-glucuronosyltransferases 1A9 and 2B7 to the glucuronidation of indomethacin in the human liver. Eur J Clin Pharmacol. 2007 Mar;63(3):289-96. DM8JXPZ RU https://www.ncbi.nlm.nih.gov/pubmed/?term=17245571 DMN6QO5 DI DMN6QO5 DMN6QO5 DN Gliclazide DMN6QO5 MI TTP835K DMN6QO5 MN ATP-binding cassette transporter C8 (ABCC8) DMN6QO5 MT DTT DMN6QO5 MA Blocker DMN6QO5 RN Structural basis for the interference between nicorandil and sulfonylurea action. Diabetes. 2001 Oct;50(10):2253-9. DMN6QO5 RU https://pubmed.ncbi.nlm.nih.gov/11574406 DMN6QO5 DI DMN6QO5 DMN6QO5 DN Gliclazide DMN6QO5 MI DE5IED8 DMN6QO5 MN Cytochrome P450 2C9 (CYP2C9) DMN6QO5 MT DME DMN6QO5 MA Metabolism DMN6QO5 RN Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. DMN6QO5 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=19515014 DMN6QO5 DI DMN6QO5 DMN6QO5 DN Gliclazide DMN6QO5 MI DEGTFWK DMN6QO5 MN Mephenytoin 4-hydroxylase (CYP2C19) DMN6QO5 MT DME DMN6QO5 MA Metabolism DMN6QO5 RN The metabolism of CYP2C9 and CYP2C19 for gliclazide by homology modeling and docking study. Eur J Med Chem. 2009 Feb;44(2):854-61. DMN6QO5 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=18541345 DM5FSJA DI DM5FSJA DM5FSJA DN Glimepiride DM5FSJA MI TTP835K DM5FSJA MN ATP-binding cassette transporter C8 (ABCC8) DM5FSJA MT DTT DM5FSJA MA Blocker DM5FSJA RN Mechanism of disopyramide-induced hypoglycaemia in a patient with Type 2 diabetes. Diabet Med. 2009 Jan;26(1):76-8. DM5FSJA RU https://pubmed.ncbi.nlm.nih.gov/19125764 DM5FSJA DI DM5FSJA DM5FSJA DN Glimepiride DM5FSJA MI TTEF5MJ DM5FSJA MN ATP-binding cassette transporter C9 (ABCC9) DM5FSJA MT DTT DM5FSJA MA Blocker DM5FSJA RN Mechanism of disopyramide-induced hypoglycaemia in a patient with Type 2 diabetes. Diabet Med. 2009 Jan;26(1):76-8. DM5FSJA RU https://pubmed.ncbi.nlm.nih.gov/19125764 DM5FSJA DI DM5FSJA DM5FSJA DN Glimepiride DM5FSJA MI DTJ0EW4 DM5FSJA MN Bile salt export pump (ABCB11) DM5FSJA MT DTP DM5FSJA MA Substrate DM5FSJA RN Early identification of clinically relevant drug interactions with the human bile salt export pump (BSEP/ABCB11). Toxicol Sci. 2013 Dec;136(2):328-43. DM5FSJA RU http://www.ncbi.nlm.nih.gov/pubmed/24014644 DM5FSJA DI DM5FSJA DM5FSJA DN Glimepiride DM5FSJA MI DE5IED8 DM5FSJA MN Cytochrome P450 2C9 (CYP2C9) DM5FSJA MT DME DM5FSJA MA Metabolism DM5FSJA RN Effect of CYP2C9 genetic polymorphisms on the efficacy and pharmacokinetics of glimepiride in subjects with type 2 diabetes. Diabetes Res Clin Pract. 2006 May;72(2):148-54. DM5FSJA RU https://www.ncbi.nlm.nih.gov/pubmed/?term=16325295 DMZA5PQ DI DMZA5PQ DMZA5PQ DN Glipizide DMZA5PQ MI DTJ0EW4 DMZA5PQ MN Bile salt export pump (ABCB11) DMZA5PQ MT DTP DMZA5PQ MA Substrate DMZA5PQ RN Early identification of clinically relevant drug interactions with the human bile salt export pump (BSEP/ABCB11). Toxicol Sci. 2013 Dec;136(2):328-43. DMZA5PQ RU http://www.ncbi.nlm.nih.gov/pubmed/24014644 DMZA5PQ DI DMZA5PQ DMZA5PQ DN Glipizide DMZA5PQ MI DE5IED8 DMZA5PQ MN Cytochrome P450 2C9 (CYP2C9) DMZA5PQ MT DME DMZA5PQ MA Metabolism DMZA5PQ RN Clinical consequences of cytochrome P450 2C9 polymorphisms. Clin Pharmacol Ther. 2005 Jan;77(1):1-16. DMZA5PQ RU https://www.ncbi.nlm.nih.gov/pubmed/?term=15637526 DMZA5PQ DI DMZA5PQ DMZA5PQ DN Glipizide DMZA5PQ MI DE4LYSA DMZA5PQ MN Cytochrome P450 3A4 (CYP3A4) DMZA5PQ MT DME DMZA5PQ MA Metabolism DMZA5PQ RN Repaglinide : a pharmacoeconomic review of its use in type 2 diabetes mellitus. Pharmacoeconomics. 2004;22(6):389-411. DMZA5PQ RU https://www.ncbi.nlm.nih.gov/pubmed/?term=15099124 DMZA5PQ DI DMZA5PQ DMZA5PQ DN Glipizide DMZA5PQ MI TTG140O DMZA5PQ MN Inward rectifier potassium channel Kir1.2 (KCNJ10) DMZA5PQ MT DTT DMZA5PQ MA Blocker DMZA5PQ RN Triggering and amplification of insulin secretion by dimethyl alpha-ketoglutarate, a membrane permeable alpha-ketoglutarate analogue. Eur J Pharmacol. 2009 Apr 1;607(1-3):41-6. DMZA5PQ RU https://pubmed.ncbi.nlm.nih.gov/19233162 DMZA5PQ DI DMZA5PQ DMZA5PQ DN Glipizide DMZA5PQ MI DEGTFWK DMZA5PQ MN Mephenytoin 4-hydroxylase (CYP2C19) DMZA5PQ MT DME DMZA5PQ MA Metabolism DMZA5PQ RN Pharmacokinetics of chlorpheniramine, phenytoin, glipizide and nifedipine in an individual homozygous for the CYP2C9*3 allele. Pharmacogenetics. 1999 Feb;9(1):71-80. DMZA5PQ RU https://www.ncbi.nlm.nih.gov/pubmed/?term=10208645 DMZA5PQ DI DMZA5PQ DMZA5PQ DN Glipizide DMZA5PQ MI DEYGVN4 DMZA5PQ MN UDP-glucuronosyltransferase 1A1 (UGT1A1) DMZA5PQ MT DME DMZA5PQ MA Metabolism DMZA5PQ RN Drug-drug interactions for UDP-glucuronosyltransferase substrates: a pharmacokinetic explanation for typically observed low exposure (AUCi/AUC) ratios. Drug Metab Dispos. 2004 Nov;32(11):1201-8. DMZA5PQ RU https://www.ncbi.nlm.nih.gov/pubmed/?term=15304429 DMB0EUX DI DMB0EUX DMB0EUX DN Gliquidone DMB0EUX MI DE5IED8 DMB0EUX MN Cytochrome P450 2C9 (CYP2C9) DMB0EUX MT DME DMB0EUX MA Metabolism DMB0EUX RN Clinically and pharmacologically relevant interactions of antidiabetic drugs. Ther Adv Endocrinol Metab. 2016 Apr;7(2):69-83. DMB0EUX RU https://www.ncbi.nlm.nih.gov/pubmed/?term=27092232 DMB0EUX DI DMB0EUX DMB0EUX DN Gliquidone DMB0EUX MI TTG140O DMB0EUX MN Inward rectifier potassium channel Kir1.2 (KCNJ10) DMB0EUX MT DTT DMB0EUX MA Binder DMB0EUX RN Hydroxyl-substituted sulfonylureas as potent inhibitors of specific [3H]glyburide binding to rat brain synaptosomes. Bioorg Med Chem. 2003 May 1;11(9):2099-113. DMB0EUX RU https://pubmed.ncbi.nlm.nih.gov/12670661 DMJPR2B DI DMJPR2B DMJPR2B DN Glisoxepide DMJPR2B MI DE5IED8 DMJPR2B MN Cytochrome P450 2C9 (CYP2C9) DMJPR2B MT DME DMJPR2B MA Metabolism DMJPR2B RN Clinically and pharmacologically relevant interactions of antidiabetic drugs. Ther Adv Endocrinol Metab. 2016 Apr;7(2):69-83. DMJPR2B RU https://www.ncbi.nlm.nih.gov/pubmed/?term=27092232 DMJPR2B DI DMJPR2B DMJPR2B DN Glisoxepide DMJPR2B MI TTG140O DMJPR2B MN Inward rectifier potassium channel Kir1.2 (KCNJ10) DMJPR2B MT DTT DMJPR2B MA Blocker DMJPR2B RN Bepridil, an antiarrhythmic drug, opens mitochondrial KATP channels, blocks sarcolemmal KATP channels, and confers cardioprotection. J Pharmacol Exp Ther. 2006 Jan;316(1):182-8. DMJPR2B RU https://pubmed.ncbi.nlm.nih.gov/16174795 DMFLUTR DI DMFLUTR DMFLUTR DN Glucagon recombinant DMFLUTR MI TT9O6WS DMFLUTR MN Glucagon receptor (GCGR) DMFLUTR MT DTT DMFLUTR MA Binder DMFLUTR RN Glucagon receptor expression and glucagon stimulation of ghrelin secretion in rat stomach. Biochem Biophys Res Commun. 2007 Jun 15;357(4):865-70. DMFLUTR RU https://pubmed.ncbi.nlm.nih.gov/17462598 DM6EL5Q DI DM6EL5Q DM6EL5Q DN Glucarpidase DM6EL5Q MI TTX81QL DM6EL5Q MN Toxic methotrexate (TM) DM6EL5Q MT DTT DM6EL5Q MA Modulator DM6EL5Q RN Nat Rev Drug Discov. 2013 Feb;12(2):87-90. DM6EL5Q RU https://pubmed.ncbi.nlm.nih.gov/23370234 DM4ZLFD DI DM4ZLFD DM4ZLFD DN Glucosamine DM4ZLFD MI DEVDYN7 DM4ZLFD MN Cytochrome P450 2E1 (CYP2E1) DM4ZLFD MT DME DM4ZLFD MA Metabolism DM4ZLFD RN Characterization of moclobemide N-oxidation in human liver microsomes. Xenobiotica. 2001 Jul;31(7):387-97. DM4ZLFD RU https://www.ncbi.nlm.nih.gov/pubmed/?term=11531003 DM4ZLFD DI DM4ZLFD DM4ZLFD DN Glucosamine DM4ZLFD MI TTRYK0X DM4ZLFD MN Interleukin-1 beta (IL1B) DM4ZLFD MT DTT DM4ZLFD MA Inhibitor DM4ZLFD RN Glucosamine inhibits IL-1beta-mediated IL-8 production in prostate cancer cells by MAPK attenuation. J Cell Biochem. 2009 Oct 1;108(2):489-98. DM4ZLFD RU https://pubmed.ncbi.nlm.nih.gov/19626664 DM4ZLFD DI DM4ZLFD DM4ZLFD DN Glucosamine DM4ZLFD MI DEGTFWK DM4ZLFD MN Mephenytoin 4-hydroxylase (CYP2C19) DM4ZLFD MT DME DM4ZLFD MA Metabolism DM4ZLFD RN Characterization of moclobemide N-oxidation in human liver microsomes. Xenobiotica. 2001 Jul;31(7):387-97. DM4ZLFD RU https://www.ncbi.nlm.nih.gov/pubmed/?term=11531003 DMAHMT9 DI DMAHMT9 DMAHMT9 DN Glutathione DMAHMT9 MI DTI7UX6 DMAHMT9 MN Breast cancer resistance protein (ABCG2) DMAHMT9 MT DTP DMAHMT9 MA Substrate DMAHMT9 RN Glutathione transport is a unique function of the ATP-binding cassette protein ABCG2. J Biol Chem. 2010 May 28;285(22):16582-7. DMAHMT9 RU http://www.ncbi.nlm.nih.gov/pubmed/20332504 DMAHMT9 DI DMAHMT9 DMAHMT9 DN Glutathione DMAHMT9 MI TT3C1VN DMAHMT9 MN Enzyme unspecific (Enz) DMAHMT9 MT DTT DMAHMT9 MA Modulator DMAHMT9 RN Methionine and cysteine affect glutathione level, glutathione-related enzyme activities and the expression of glutathione S-transferase isozymes in rat hepatocytes. J Nutr. 1997 Nov;127(11):2135-41. DMAHMT9 RU https://pubmed.ncbi.nlm.nih.gov/9372907 DMAHMT9 DI DMAHMT9 DMAHMT9 DN Glutathione DMAHMT9 MI DEKW6PB DMAHMT9 MN Gamma-glutamylcyclotransferase (GGCT) DMAHMT9 MT DME DMAHMT9 MA Metabolism DMAHMT9 RN Characterization of the mechanism of thioredoxin-dependent activation of gamma-glutamylcyclotransferase, RipAY, from Ralstonia solanacearum. Biochem Biophys Res Commun. 2020 Mar 12;523(3):759-765. DMAHMT9 RU https://pubmed.ncbi.nlm.nih.gov/31948763 DMAHMT9 DI DMAHMT9 DMAHMT9 DN Glutathione DMAHMT9 MI DEB4JZV DMAHMT9 MN Gamma-glutamylcyclotransferase 2 (CHAC2) DMAHMT9 MT DME DMAHMT9 MA Metabolism DMAHMT9 RN ChaC2, an enzyme for slow turnover of cytosolic glutathione. J Biol Chem. 2017 Jan 13;292(2):638-651. DMAHMT9 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=27913623 DMAHMT9 DI DMAHMT9 DMAHMT9 DN Glutathione DMAHMT9 MI DEH6CAO DMAHMT9 MN Gamma-glutamyltranspeptidase 5 (GGT5) DMAHMT9 MT DME DMAHMT9 MA Metabolism DMAHMT9 RN Gamma-glutamyl compounds: substrate specificity of gamma-glutamyl transpeptidase enzymes. Anal Biochem. 2011 Jul 15;414(2):208-14. DMAHMT9 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=21447318 DMAHMT9 DI DMAHMT9 DMAHMT9 DN Glutathione DMAHMT9 MI DEOS3FD DMAHMT9 MN Glutathione peroxidase 6 (GPX6) DMAHMT9 MT DME DMAHMT9 MA Metabolism DMAHMT9 RN Metabolomics reveals a role for the chromatin-binding protein HMGN5 in glutathione metabolism. PLoS One. 2014 Jan 2;9(1):e84583. DMAHMT9 RU https://pubmed.ncbi.nlm.nih.gov/24392144 DMAHMT9 DI DMAHMT9 DMAHMT9 DN Glutathione DMAHMT9 MI DEZSNJD DMAHMT9 MN Glutathione S-transferase omega-1 (GSTO1) DMAHMT9 MT DME DMAHMT9 MA Metabolism DMAHMT9 RN Structural insights into the dehydroascorbate reductase activity of human omega-class glutathione transferases. J Mol Biol. 2012 Jul 13;420(3):190-203. DMAHMT9 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=22522127 DMAHMT9 DI DMAHMT9 DMAHMT9 DN Glutathione DMAHMT9 MI DEHMPZR DMAHMT9 MN Glutathione S-transferase omega-2 (GSTO2) DMAHMT9 MT DME DMAHMT9 MA Metabolism DMAHMT9 RN Structural insights into the dehydroascorbate reductase activity of human omega-class glutathione transferases. J Mol Biol. 2012 Jul 13;420(3):190-203. DMAHMT9 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=22522127 DMAHMT9 DI DMAHMT9 DMAHMT9 DN Glutathione DMAHMT9 MI DTSYQGK DMAHMT9 MN Multidrug resistance-associated protein 1 (ABCC1) DMAHMT9 MT DTP DMAHMT9 MA Substrate DMAHMT9 RN Structural determinants of substrate specificity differences between human multidrug resistance protein (MRP) 1 (ABCC1) and MRP3 (ABCC3). Drug Metab Dispos. 2008 Dec;36(12):2571-81. DMAHMT9 RU http://www.ncbi.nlm.nih.gov/pubmed/18775981 DMAHMT9 DI DMAHMT9 DMAHMT9 DN Glutathione DMAHMT9 MI DTFI42L DMAHMT9 MN Multidrug resistance-associated protein 2 (ABCC2) DMAHMT9 MT DTP DMAHMT9 MA Substrate DMAHMT9 RN Oxidative and electrophilic stress induces multidrug resistance-associated protein transporters via the nuclear factor-E2-related factor-2 transcriptional pathway. Hepatology. 2007 Nov;46(5):1597-610. DMAHMT9 RU http://www.ncbi.nlm.nih.gov/pubmed/17668877 DMAHMT9 DI DMAHMT9 DMAHMT9 DN Glutathione DMAHMT9 MI DTCSGPB DMAHMT9 MN Multidrug resistance-associated protein 4 (ABCC4) DMAHMT9 MT DTP DMAHMT9 MA Substrate DMAHMT9 RN Role of glutathione in the multidrug resistance protein 4 (MRP4/ABCC4)-mediated efflux of cAMP and resistance to purine analogues. Biochem J. 2002 Feb 1;361(Pt 3):497-503. DMAHMT9 RU https://doi.org/10.1042/0264-6021:3610497 DMAHMT9 DI DMAHMT9 DMAHMT9 DN Glutathione DMAHMT9 MI DT9C1TS DMAHMT9 MN Organic anion transporting polypeptide 1B3 (SLCO1B3) DMAHMT9 MT DTP DMAHMT9 MA Substrate DMAHMT9 RN Regulation of Organic Anion Transporting Polypeptides (OATP) 1B1- and OATP1B3-Mediated Transport: An Updated Review in the Context of OATP-Mediated Drug-Drug Interactions. Int J Mol Sci. 2018 Mar 14;19(3). pii: E855. DMAHMT9 RU http://www.ncbi.nlm.nih.gov/pubmed/29538325 DMAHMT9 DI DMAHMT9 DMAHMT9 DN Glutathione DMAHMT9 MI DTUGYRD DMAHMT9 MN P-glycoprotein 1 (ABCB1) DMAHMT9 MT DTP DMAHMT9 MA Substrate DMAHMT9 RN Upregulation of cellular glutathione levels in human ABCB5- and murine Abcb5-transfected cells. BMC Pharmacol Toxicol. 2015 Dec 15;16:37. DMAHMT9 RU http://www.ncbi.nlm.nih.gov/pubmed/26666373 DMGE0CW DI DMGE0CW DMGE0CW DN Glutethimide DMGE0CW MI TTVG215 DMGE0CW MN Debrisoquine 4-hydroxylase (CYP2D6) DMGE0CW MT DTT DMGE0CW MA Inducer DMGE0CW RN A study of the effects of large doses of glutethimide that were used for self-poisoning during pregnancy on human fetuses. Toxicol Ind Health. 2008 Feb-Mar;24(1-2):69-78. DMGE0CW RU https://pubmed.ncbi.nlm.nih.gov/18818183 DMGE0CW DI DMGE0CW DMGE0CW DN Glutethimide DMGE0CW MI DEA3U9Y DMGE0CW MN Myeloperoxidase (MPO) DMGE0CW MT DME DMGE0CW MA Metabolism DMGE0CW RN Proteomic profile of aminoglutethimide-induced apoptosis in HL-60 cells: role of myeloperoxidase and arylamine free radicals. Chem Biol Interact. 2015 Sep 5;239:129-38. DMGE0CW RU https://www.ncbi.nlm.nih.gov/pubmed/?term=26102013 DMDGRQO DI DMDGRQO DMDGRQO DN Glycerol phenylbutyrate DMDGRQO MI DEVOTU4 DMDGRQO MN Aquaporin adipose (AQP7) DMDGRQO MT DME DMDGRQO MA Metabolism DMDGRQO RN Aquaporins in the human testis and spermatozoa - identification, involvement in sperm volume regulation and clinical relevance. Int J Androl. 2010 Aug 1;33(4):629-41. DMDGRQO RU https://www.ncbi.nlm.nih.gov/pubmed/?term=19840149 DMDGRQO DI DMDGRQO DMDGRQO DN Glycerol phenylbutyrate DMDGRQO MI DEDI8VX DMDGRQO MN Propanediol dehydrogenase (dhaT) DMDGRQO MT DME DMDGRQO MA Metabolism DMDGRQO RN Expression and characterization of a novel 1,3-propanediol dehydrogenase from Lactobacillus brevis. Appl Biochem Biotechnol. 2016 Jul;179(6):959-72. DMDGRQO RU https://pubmed.ncbi.nlm.nih.gov/26961082 DMIOZ29 DI DMIOZ29 DMIOZ29 DN Glycine DMIOZ29 MI DTW7AE3 DMIOZ29 MN Alanine/serine/cysteine/threonine transporter 2 (SLC1A5) DMIOZ29 MT DTP DMIOZ29 MA Substrate DMIOZ29 RN Transport of butyryl-L-carnitine, a potential prodrug, via the carnitine transporter OCTN2 and the amino acid transporter ATB(0,+). Am J Physiol Gastrointest Liver Physiol. 2007 Nov;293(5):G1046-53. DMIOZ29 RU http://www.ncbi.nlm.nih.gov/pubmed/17855766 DMIOZ29 DI DMIOZ29 DMIOZ29 DN Glycine DMIOZ29 MI DERA3OF DMIOZ29 MN Bile acid-CoA thioesterase (BAAT) DMIOZ29 MT DME DMIOZ29 MA Metabolism DMIOZ29 RN Bile acid coenzyme A: amino acid N-acyltransferase in the amino acid conjugation of bile acids. Methods Enzymol. 2005;400:374-94. DMIOZ29 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=16399361 DMIOZ29 DI DMIOZ29 DMIOZ29 DN Glycine DMIOZ29 MI DE437BY DMIOZ29 MN Delta-aminolevulinate synthase 2 (ALAS2) DMIOZ29 MT DME DMIOZ29 MA Metabolism DMIOZ29 RN Molecular expression and characterization of erythroid-specific 5-aminolevulinate synthase gain-of-function mutations causing X-linked protoporphyria. Mol Med. 2013 Mar 5;19:18-25. DMIOZ29 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=23348515 DMIOZ29 DI DMIOZ29 DMIOZ29 DN Glycine DMIOZ29 MI TTKJEMQ DMIOZ29 MN Glutamate receptor ionotropic NMDA 2A (NMDAR2A) DMIOZ29 MT DTT DMIOZ29 MA Antagonist DMIOZ29 RN Glycine transport inhibitors for the treatment of schizophrenia: Symptom and disease modification. Curr Opin Drug Discov Devel. 2009 Jul;12(4):468-78. DMIOZ29 RU https://pubmed.ncbi.nlm.nih.gov/19562643 DMIOZ29 DI DMIOZ29 DMIOZ29 DN Glycine DMIOZ29 MI DTJF3DX DMIOZ29 MN L-type amino acid transporter 2 (SLC7A8) DMIOZ29 MT DTP DMIOZ29 MA Substrate DMIOZ29 RN The Transporter Classification Database (TCDB): recent advances. Nucleic Acids Res. 2016 Jan 4;44(D1):D372-9. (ID: 2.A.3.8.20) DMIOZ29 RU http://www.tcdb.org/search/result.php?tc=2.A.3.8.20 DMIOZ29 DI DMIOZ29 DMIOZ29 DN Glycine DMIOZ29 MI DTBPTJF DMIOZ29 MN Na(+)/Cl(-) betaine/GABA transporter (SLC6A12) DMIOZ29 MT DTP DMIOZ29 MA Substrate DMIOZ29 RN Interpreting metabolomic profiles using unbiased pathway models. PLoS Comput Biol. 2010 Feb 26;6(2):e1000692. DMIOZ29 RU http://www.ncbi.nlm.nih.gov/pubmed/20195502 DMIOZ29 DI DMIOZ29 DMIOZ29 DN Glycine DMIOZ29 MI DT48WEM DMIOZ29 MN Proton-coupled amino acid transporter 1 (SLC36A1) DMIOZ29 MT DTP DMIOZ29 MA Substrate DMIOZ29 RN Transport of amino acids and GABA analogues via the human proton-coupled amino acid transporter, hPAT1: characterization of conditions for affinity and transport experiments in Caco-2 cells. Eur J Pharm Sci. 2008 Sep 2;35(1-2):86-95. DMIOZ29 RU http://www.ncbi.nlm.nih.gov/pubmed/18621125 DMIOZ29 DI DMIOZ29 DMIOZ29 DN Glycine DMIOZ29 MI DT2CFQ5 DMIOZ29 MN Sodium- and chloride-dependent glycine transporter 1 (SLC6A9) DMIOZ29 MT DTP DMIOZ29 MA Substrate DMIOZ29 RN Mutation in SLC6A9 encoding a glycine transporter causes a novel form of non-ketotic hyperglycinemia in humans. Hum Genet. 2016 Nov;135(11):1263-1268. DMIOZ29 RU http://www.ncbi.nlm.nih.gov/pubmed/27481395 DMIOZ29 DI DMIOZ29 DMIOZ29 DN Glycine DMIOZ29 MI DTE8R17 DMIOZ29 MN Sodium- and chloride-dependent glycine transporter 2 (SLC6A5) DMIOZ29 MT DTP DMIOZ29 MA Substrate DMIOZ29 RN Mutations in the GlyT2 gene (SLC6A5) are a second major cause of startle disease. J Biol Chem. 2012 Aug 17;287(34):28975-85. DMIOZ29 RU http://www.ncbi.nlm.nih.gov/pubmed/22700964 DM1WL9O DI DM1WL9O DM1WL9O DN Glycodiazine DM1WL9O MI TTG140O DM1WL9O MN Inward rectifier potassium channel Kir1.2 (KCNJ10) DM1WL9O MT DTT DM1WL9O MA Binder DM1WL9O RN Coupling between proximal tubular transport processes. Studies with ouabain, SITS and HCO3-free solutions. Pflugers Arch. 1977 Apr 25;368(3):245-52. DM1WL9O RU https://pubmed.ncbi.nlm.nih.gov/141035 DM2M3ZA DI DM2M3ZA DM2M3ZA DN Glycopyrrolate DM2M3ZA MI TTZ9SOR DM2M3ZA MN Muscarinic acetylcholine receptor M1 (CHRM1) DM2M3ZA MT DTT DM2M3ZA MA Antagonist DM2M3ZA RN Autonomic cardiovascular control during a novel pharmacologic alternative to ganglionic blockade. Clin Pharmacol Ther. 2008 May;83(5):692-701. DM2M3ZA RU https://pubmed.ncbi.nlm.nih.gov/17687267 DM2M3ZA DI DM2M3ZA DM2M3ZA DN Glycopyrrolate DM2M3ZA MI DTT79CX DM2M3ZA MN Organic cation transporter 1 (SLC22A1) DM2M3ZA MT DTP DM2M3ZA MA Substrate DM2M3ZA RN Identification of novel substrates and structure-activity relationship of cellular uptake mediated by human organic cation transporters 1 and 2. J Med Chem. 2013 Sep 26;56(18):7232-42. DM2M3ZA RU http://www.ncbi.nlm.nih.gov/pubmed/23984907 DMGVJLB DI DMGVJLB DMGVJLB DN GMA-161 DMGVJLB MI TT7KTSR DMGVJLB MN Immunoglobulin gamma Fc receptor III (FCGR3) DMGVJLB MT DTT DMGVJLB MA Antagonist DMGVJLB RN Emerging drugs for idiopathic thrombocytopenic purpura in adults. Expert Opin Emerg Drugs. 2008 Jun;13(2):237-54. DMGVJLB RU https://pubmed.ncbi.nlm.nih.gov/18537519 DMHZV7X DI DMHZV7X DMHZV7X DN Golimumab DMHZV7X MI TTF8CQI DMHZV7X MN Tumor necrosis factor (TNF) DMHZV7X MT DTT DMHZV7X RN Hughes B: 2009 FDA drug approvals. Nat Rev Drug Discov. 2010 Feb;9(2):89-92. DMHZV7X RU https://pubmed.ncbi.nlm.nih.gov/20118952 DMAQ469 DI DMAQ469 DMAQ469 DN Gonadorelin DMAQ469 MI TT8R70G DMAQ469 MN Gonadotropin-releasing hormone receptor (GNRHR) DMAQ469 MT DTT DMAQ469 MA Agonist DMAQ469 RN Use of cognitive behavior therapy for functional hypothalamic amenorrhea. Ann N Y Acad Sci. 2006 Dec;1092:114-29. DMAQ469 RU https://pubmed.ncbi.nlm.nih.gov/17308138 DMAQ469 DI DMAQ469 DMAQ469 DN Gonadorelin DMAQ469 MI DEYCUQ2 DMAQ469 MN Metallo-endopeptidase-like 1 (MMEL1) DMAQ469 MT DME DMAQ469 MA Metabolism DMAQ469 RN Cell-specific activity of neprilysin 2 isoforms and enzymic specificity compared with neprilysin. Biochem J. 2002 May 1;363(Pt 3):697-705. DMAQ469 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=11964170 DMAQ469 DI DMAQ469 DMAQ469 DN Gonadorelin DMAQ469 MI DEVSCNZ DMAQ469 MN Prolyl endopeptidase (PREP) DMAQ469 MT DME DMAQ469 MA Metabolism DMAQ469 RN Ion-exchange chromatography: basic principles and application to the partial purification of soluble mammalian prolyl oligopeptidase. Methods Mol Biol. 2011;681:215-28. DMAQ469 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=20978968 DMAQ469 DI DMAQ469 DMAQ469 DN Gonadorelin DMAQ469 MI DE95LJC DMAQ469 MN Thimet oligopeptidase (THOP1) DMAQ469 MT DME DMAQ469 MA Metabolism DMAQ469 RN Sleep deprivation changes thimet oligopeptidase (THOP1) expression and activity in rat brain. Heliyon. 2019 Nov 26;5(11):e02896. DMAQ469 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=31828230 DMAT8CG DI DMAT8CG DMAT8CG DN Goserelin DMAT8CG MI TT0ID4A DMAT8CG MN Leutinizing-hormone-releasing hormone (GNRH1) DMAT8CG MT DTT DMAT8CG MA Activator DMAT8CG RN Long-term effectiveness of adjuvant goserelin in premenopausal women with early breast cancer. J Natl Cancer Inst. 2009 Mar 4;101(5):341-9. DMAT8CG RU https://pubmed.ncbi.nlm.nih.gov/19244174 DMPT74U DI DMPT74U DMPT74U DN Gramicidin D DMPT74U MI TT4ILYC DMPT74U MN Bacterial Dihydropteroate synthetase (Bact folP) DMPT74U MT DTT DMPT74U MA Binder DMPT74U RN Structures of gramicidins A, B, and C incorporated into sodium dodecyl sulfate micelles. Biochemistry. 2001 Oct 2;40(39):11676-86. DMPT74U RU https://pubmed.ncbi.nlm.nih.gov/11570868 DMPT74U DI DMPT74U DMPT74U DN Gramicidin D DMPT74U MI DTUGYRD DMPT74U MN P-glycoprotein 1 (ABCB1) DMPT74U MT DTP DMPT74U MA Substrate DMPT74U RN Mammalian drug efflux transporters of the ATP binding cassette (ABC) family in multidrug resistance: A review of the past decade. Cancer Lett. 2016 Jan 1;370(1):153-64. DMPT74U RU http://www.ncbi.nlm.nih.gov/pubmed/26499806 DMIUW25 DI DMIUW25 DMIUW25 DN Granisetron DMIUW25 MI TTNXLKE DMIUW25 MN 5-HT 3 receptor (5HT3R) DMIUW25 MT DTT DMIUW25 MA Antagonist DMIUW25 RN New approaches to chemotherapy-induced nausea and vomiting: from neuropharmacology to clinical investigations. Cancer J. 2006 Sep-Oct;12(5):341-7. DMIUW25 RU https://pubmed.ncbi.nlm.nih.gov/17034670 DMIUW25 DI DMIUW25 DMIUW25 DN Granisetron DMIUW25 MI DE6OQ3W DMIUW25 MN Cytochrome P450 1A1 (CYP1A1) DMIUW25 MT DME DMIUW25 MA Metabolism DMIUW25 RN CYP1A1 is a major enzyme responsible for the metabolism of granisetron in human liver microsomes. Curr Drug Metab. 2005 Oct;6(5):469-80. DMIUW25 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=16248838 DMIUW25 DI DMIUW25 DMIUW25 DN Granisetron DMIUW25 MI DEJGDUW DMIUW25 MN Cytochrome P450 1A2 (CYP1A2) DMIUW25 MT DME DMIUW25 MA Metabolism DMIUW25 RN Heterogeneity in systemic availability of ondansetron and granisetron following oral administration. Drug Metab Dispos. 1999 Jan;27(1):110-2. DMIUW25 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=9884318 DMIUW25 DI DMIUW25 DMIUW25 DN Granisetron DMIUW25 MI DECB0K3 DMIUW25 MN Cytochrome P450 2D6 (CYP2D6) DMIUW25 MT DME DMIUW25 MA Metabolism DMIUW25 RN Granisetron: new insights into its use for the treatment of chemotherapy-induced nausea and vomiting. Expert Opin Pharmacother. 2003 Sep;4(9):1563-71. DMIUW25 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=12943486 DMIUW25 DI DMIUW25 DMIUW25 DN Granisetron DMIUW25 MI DE4LYSA DMIUW25 MN Cytochrome P450 3A4 (CYP3A4) DMIUW25 MT DME DMIUW25 MA Metabolism DMIUW25 RN CYP1A1 is a major enzyme responsible for the metabolism of granisetron in human liver microsomes. Curr Drug Metab. 2005 Oct;6(5):469-80. DMIUW25 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=16248838 DMIUW25 DI DMIUW25 DMIUW25 DN Granisetron DMIUW25 MI DEIBDNY DMIUW25 MN Cytochrome P450 3A5 (CYP3A5) DMIUW25 MT DME DMIUW25 MA Metabolism DMIUW25 RN Characterisation of the cytochrome P450 enzymes involved in the in vitro metabolism of granisetron. Br J Clin Pharmacol. 1994 Dec;38(6):557-66. DMIUW25 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=7888294 DMGLX0T DI DMGLX0T DMGLX0T DN Grepafloxacin DMGLX0T MI TTN6J5F DMGLX0T MN Bacterial DNA gyrase (Bact gyrase) DMGLX0T MT DTT DMGLX0T MA Modulator DMGLX0T RN Grepafloxacin, a dimethyl derivative of ciprofloxacin, acts preferentially through gyrase in Streptococcus pneumoniae: role of the C-5 group in tar... Antimicrob Agents Chemother. 2002 Feb;46(2):582-5. DMGLX0T RU https://www.ncbi.nlm.nih.gov/pubmed/11796384 DMGLX0T DI DMGLX0T DMGLX0T DN Grepafloxacin DMGLX0T MI DTI7UX6 DMGLX0T MN Breast cancer resistance protein (ABCG2) DMGLX0T MT DTP DMGLX0T MA Substrate DMGLX0T RN Involvement of breast cancer resistance protein (ABCG2) in the biliary excretion mechanism of fluoroquinolones. Drug Metab Dispos. 2007 Oct;35(10):1873-9. DMGLX0T RU http://www.ncbi.nlm.nih.gov/pubmed/17639028 DMGLX0T DI DMGLX0T DMGLX0T DN Grepafloxacin DMGLX0T MI DEJGDUW DMGLX0T MN Cytochrome P450 1A2 (CYP1A2) DMGLX0T MT DME DMGLX0T MA Metabolism DMGLX0T RN Quantitative prediction of drug interactions caused by CYP1A2 inhibitors and inducers. Clin Pharmacokinet. 2016 Aug;55(8):977-90. DMGLX0T RU https://www.ncbi.nlm.nih.gov/pubmed/?term=26936044 DMGLX0T DI DMGLX0T DMGLX0T DN Grepafloxacin DMGLX0T MI DE4LYSA DMGLX0T MN Cytochrome P450 3A4 (CYP3A4) DMGLX0T MT DME DMGLX0T MA Metabolism DMGLX0T RN MDR- and CYP3A4-mediated drug-drug interactions. J Neuroimmune Pharmacol. 2006 Sep;1(3):323-39. DMGLX0T RU https://www.ncbi.nlm.nih.gov/pubmed/?term=18040809 DMGLX0T DI DMGLX0T DMGLX0T DN Grepafloxacin DMGLX0T MI DTSYQGK DMGLX0T MN Multidrug resistance-associated protein 1 (ABCC1) DMGLX0T MT DTP DMGLX0T MA Substrate DMGLX0T RN Limited distribution of new quinolone antibacterial agents into brain caused by multiple efflux transporters at the blood-brain barrier. J Pharmacol Exp Ther. 2000 Oct;295(1):146-52. DMGLX0T RU http://jpet.aspetjournals.org/content/295/1/146.long DMGLX0T DI DMGLX0T DMGLX0T DN Grepafloxacin DMGLX0T MI DTFI42L DMGLX0T MN Multidrug resistance-associated protein 2 (ABCC2) DMGLX0T MT DTP DMGLX0T MA Substrate DMGLX0T RN Fluoroquinolone efflux mediated by ABC transporters. J Pharm Sci. 2008 Sep;97(9):3483-93. DMGLX0T RU http://www.ncbi.nlm.nih.gov/pubmed/18200507 DMGLX0T DI DMGLX0T DMGLX0T DN Grepafloxacin DMGLX0T MI DTE2B1D DMGLX0T MN Organic anion transporting polypeptide 1A2 (SLCO1A2) DMGLX0T MT DTP DMGLX0T MA Substrate DMGLX0T RN Identification of influx transporter for the quinolone antibacterial agent levofloxacin. Mol Pharm. 2007 Jan-Feb;4(1):85-94. DMGLX0T RU http://www.ncbi.nlm.nih.gov/pubmed/17274666 DMGLX0T DI DMGLX0T DMGLX0T DN Grepafloxacin DMGLX0T MI DTUGYRD DMGLX0T MN P-glycoprotein 1 (ABCB1) DMGLX0T MT DTP DMGLX0T MA Substrate DMGLX0T RN Mammalian drug efflux transporters of the ATP binding cassette (ABC) family in multidrug resistance: A review of the past decade. Cancer Lett. 2016 Jan 1;370(1):153-64. DMGLX0T RU http://www.ncbi.nlm.nih.gov/pubmed/26499806 DMK54YG DI DMK54YG DMK54YG DN Griseofulvin DMK54YG MI DEJGDUW DMK54YG MN Cytochrome P450 1A2 (CYP1A2) DMK54YG MT DME DMK54YG MA Metabolism DMK54YG RN Kinetic mechanism of the activation of human plasminogen by streptokinase. Biochemistry. 1975 Oct 7;14(20):4459-65. DMK54YG RU https://www.ncbi.nlm.nih.gov/pubmed/?term=126078 DMK54YG DI DMK54YG DMK54YG DN Griseofulvin DMK54YG MI TT7PBUD DMK54YG MN Fungal Microtubule (Fung MicroTU) DMK54YG MT DTT DMK54YG MA Inducer DMK54YG RN Dermatophyte infections. Am Fam Physician. 2003 Jan 1;67(1):101-8. DMK54YG RU https://pubmed.ncbi.nlm.nih.gov/12537173 DM1ECNJ DI DM1ECNJ DM1ECNJ DN GS-7340 DM1ECNJ MI TT84ETX DM1ECNJ MN Human immunodeficiency virus Reverse transcriptase (HIV RT) DM1ECNJ MT DTT DM1ECNJ MA Inhibitor DM1ECNJ RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2020 DM1ECNJ RU https://www.accessdata.fda.gov/drugsatfda_docs/label/2020/208464s008lbl.pdf DM8QB0T DI DM8QB0T DM8QB0T DN GSK2592984A DM8QB0T MI TT3J5ZI DM8QB0T MN Cell mediated immunity response (CMIR) DM8QB0T MT DTT DM8QB0T RN Anti-influenza agents from Traditional Chinese Medicine. Nat Prod Rep. 2010 Jan;27(12):1758-80. DM8QB0T RU https://pubmed.ncbi.nlm.nih.gov/20941447 DM5QWEL DI DM5QWEL DM5QWEL DN Guanabenz DM5QWEL MI TTQ8AFT DM5QWEL MN Adrenergic receptor Alpha-2 (ADRA2) DM5QWEL MT DTT DM5QWEL MA Agonist DM5QWEL RN Centrally acting sympathetic inhibitors for therapy of patients with hypertension. Nippon Rinsho. 1997 Aug;55(8):2081-5. DM5QWEL RU https://pubmed.ncbi.nlm.nih.gov/9284427 DM5QWEL DI DM5QWEL DM5QWEL DN Guanabenz DM5QWEL MI DEJGDUW DM5QWEL MN Cytochrome P450 1A2 (CYP1A2) DM5QWEL MT DME DM5QWEL MA Metabolism DM5QWEL RN Synthetic and natural compounds that interact with human cytochrome P450 1A2 and implications in drug development. Curr Med Chem. 2009;16(31):4066-218. DM5QWEL RU https://www.ncbi.nlm.nih.gov/pubmed/?term=19754423 DM5QWEL DI DM5QWEL DM5QWEL DN Guanabenz DM5QWEL MI DTUGYRD DM5QWEL MN P-glycoprotein 1 (ABCB1) DM5QWEL MT DTP DM5QWEL MA Substrate DM5QWEL RN A novel screening strategy to identify ABCB1 substrates and inhibitors. Naunyn Schmiedebergs Arch Pharmacol. 2009 Jan;379(1):11-26. DM5QWEL RU https://doi.org/10.1007/s00210-008-0345-0 DM6S157 DI DM6S157 DM6S157 DN Guanadrel Sulfate DM6S157 MI TTVIREA DM6S157 MN Adrenergic receptor (ADR) DM6S157 MT DTT DM6S157 MA Modulator DM6S157 RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. DM6S157 RU https://www.fda.gov/ DM9NSWT DI DM9NSWT DM9NSWT DN Guanethidine DM9NSWT MI TTT04VN DM9NSWT MN Adrenergic neuron (AD neuro) DM9NSWT MT DTT DM9NSWT MA Blocker DM9NSWT RN Characterization of bradykinin-induced endothelium-independent contraction in equine basilar artery. J Vet Pharmacol Ther. 2009 Jun;32(3):264-70. DM9NSWT RU https://pubmed.ncbi.nlm.nih.gov/19646091 DMB1CZ8 DI DMB1CZ8 DMB1CZ8 DN Guanfacine extended release DMB1CZ8 MI TTQ8AFT DMB1CZ8 MN Adrenergic receptor Alpha-2 (ADRA2) DMB1CZ8 MT DTT DMB1CZ8 MA Agonist DMB1CZ8 RN Emerging drugs for attention-deficit/hyperactivity disorder. Expert Opin Emerg Drugs. 2007 Sep;12(3):423-34. DMB1CZ8 RU https://pubmed.ncbi.nlm.nih.gov/17874970 DMB1CZ8 DI DMB1CZ8 DMB1CZ8 DN Guanfacine extended release DMB1CZ8 MI TTMSFAW DMB1CZ8 MN Cannabinoid receptor 2 (CB2) DMB1CZ8 MT DTT DMB1CZ8 MA Agonist DMB1CZ8 RN Posttraining activation of CB1 cannabinoid receptors in the CA1 region of the dorsal hippocampus impairs object recognition long-term memory. Neurobiol Learn Mem. 2008 Sep;90(2):374-81. DMB1CZ8 RU https://pubmed.ncbi.nlm.nih.gov/18524639 DMB1CZ8 DI DMB1CZ8 DMB1CZ8 DN Guanfacine extended release DMB1CZ8 MI TT7QNVC DMB1CZ8 MN Glucose-dependent insulinotropic receptor (GPR119) DMB1CZ8 MT DTT DMB1CZ8 MA Agonist DMB1CZ8 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 126). DMB1CZ8 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=126 DMB1CZ8 DI DMB1CZ8 DMB1CZ8 DN Guanfacine extended release DMB1CZ8 MI TTNET8J DMB1CZ8 MN G-protein coupled receptor 55 (GPR55) DMB1CZ8 MT DTT DMB1CZ8 MA Agonist DMB1CZ8 RN The orphan receptor GPR55 is a novel cannabinoid receptor. Br J Pharmacol. 2007 Dec;152(7):1092-101. DMB1CZ8 RU https://pubmed.ncbi.nlm.nih.gov/17876302 DM0P63W DI DM0P63W DM0P63W DN Guanidine Hydrochloride DM0P63W MI TTQ8AFT DM0P63W MN Adrenergic receptor Alpha-2 (ADRA2) DM0P63W MT DTT DM0P63W MA Modulator DM0P63W RN Guanidine-based 2-adrenoceptor ligands: Towards selective antagonist activity.Eur J Med Chem.2014 Jul 23;82:242-54. DM0P63W RU https://www.ncbi.nlm.nih.gov/pubmed/24908653 DMP7LK1 DI DMP7LK1 DMP7LK1 DN Guggulsterone DMP7LK1 MI TTS4UGC DMP7LK1 MN Farnesoid X-activated receptor (FXR) DMP7LK1 MT DTT DMP7LK1 MA Antagonist DMP7LK1 RN Effect of guggulsterone and cembranoids of Commiphora mukul on pancreatic phospholipase A(2): role in hypocholesterolemia. J Nat Prod. 2009 Jan;72(1):24-8. DMP7LK1 RU https://pubmed.ncbi.nlm.nih.gov/19102680 DMP7LK1 DI DMP7LK1 DMP7LK1 DN Guggulsterone DMP7LK1 MI DTUGYRD DMP7LK1 MN P-glycoprotein 1 (ABCB1) DMP7LK1 MT DTP DMP7LK1 MA Substrate DMP7LK1 RN Effects of plant sterols on human multidrug transporters ABCB1 and ABCC1. Biochem Biophys Res Commun. 2008 May 2;369(2):363-8. DMP7LK1 RU https://doi.org/10.1016/j.bbrc.2008.02.026 DMV4KOA DI DMV4KOA DMV4KOA DN GW642444 DMV4KOA MI TT2CJVK DMV4KOA MN Adrenergic receptor beta-2 (ADRB2) DMV4KOA MT DTT DMV4KOA MA Agonist DMV4KOA RN Clinical pipeline report, company report or official report of GlaxoSmithKline (2009). DMV4KOA RU http://www.gsk.com/investors/product_pipeline/docs/gsk-pipeline-feb09.pdf DML72VJ DI DML72VJ DML72VJ DN GW685698X DML72VJ MI TTYRL6O DML72VJ MN Glucocorticoid receptor (NR3C1) DML72VJ MT DTT DML72VJ MA Agonist DML72VJ RN Clinical pipeline report, company report or official report of GlaxoSmithKline (2009). DML72VJ RU http://www.gsk.com/investors/product_pipeline/docs/gsk-pipeline-feb09.pdf DMFUAXT DI DMFUAXT DMFUAXT DN H1N1 pandemic influenza A vaccine DMFUAXT MI TT3J5ZI DMFUAXT MN Cell mediated immunity response (CMIR) DMFUAXT MT DTT DMFUAXT RN How Influenza (Flu) Vaccines Are Made. FLU.gov. 2014. DMFUAXT RU http://www.flu.gov/about_the_flu/h1n1/ DMMHYLB DI DMMHYLB DMMHYLB DN H5N1 influenza vaccine DMMHYLB MI TT3J5ZI DMMHYLB MN Cell mediated immunity response (CMIR) DMMHYLB MT DTT DMMHYLB RN Comparative clinical trial of vaccines against avian influenza. Zh Mikrobiol Epidemiol Immunobiol. 2007 May-Jun;(3):10-6. DMMHYLB RU https://pubmed.ncbi.nlm.nih.gov/17672124 DM7JNTV DI DM7JNTV DM7JNTV DN Halaven DM7JNTV MI DE4LYSA DM7JNTV MN Cytochrome P450 3A4 (CYP3A4) DM7JNTV MT DME DM7JNTV MA Metabolism DM7JNTV RN Eribulin, a microtubule inhibitor for metastatic breast cancer. Oncology (Williston Park). 2011 Feb;25(2 Suppl Nurse Ed):46-8. DM7JNTV RU https://www.ncbi.nlm.nih.gov/pubmed/?term=25373284 DMPFWO6 DI DMPFWO6 DMPFWO6 DN Halazepam DMPFWO6 MI TTPTXIN DMPFWO6 MN Translocator protein (TSPO) DMPFWO6 MT DTT DMPFWO6 MA Modulator DMPFWO6 RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. DMPFWO6 RU https://www.fda.gov/ DMGLAX1 DI DMGLAX1 DMGLAX1 DN Halcinonide DMGLAX1 MI DE4LYSA DMGLAX1 MN Cytochrome P450 3A4 (CYP3A4) DMGLAX1 MT DME DMGLAX1 MA Metabolism DMGLAX1 RN NCIthesaurus: Halcinonide DMGLAX1 RU https://ncit-stage.nci.nih.gov/ncitbrowser/pages/concept_details.jsf?dictionary=NCI_Thesaurus&version=18.06d&code=C47552&ns=ncit&type=relationship&key=null&b=1&n=0&vse=null DMGLAX1 DI DMGLAX1 DMGLAX1 DN Halcinonide DMGLAX1 MI TTP3UTW DMGLAX1 MN Steroid hormone receptor ERR (ESRR) DMGLAX1 MT DTT DMGLAX1 MA Modulator DMGLAX1 RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. DMGLAX1 RU https://www.fda.gov/ DM3GB6S DI DM3GB6S DM3GB6S DN Halobetasol propionate DM3GB6S MI TTP3UTW DM3GB6S MN Steroid hormone receptor ERR (ESRR) DM3GB6S MT DTT DM3GB6S MA Modulator DM3GB6S RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. DM3GB6S RU https://www.fda.gov/ DMOMK1V DI DMOMK1V DMOMK1V DN Halofantrine DMOMK1V MI TTV3NH6 DMOMK1V MN Calmodulin (CALM) DMOMK1V MT DTT DMOMK1V MA Modulator DMOMK1V RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. DMOMK1V RU https://www.fda.gov/ DMOMK1V DI DMOMK1V DMOMK1V DN Halofantrine DMOMK1V MI DES5XRU DMOMK1V MN Cytochrome P450 2C8 (CYP2C8) DMOMK1V MT DME DMOMK1V MA Metabolism DMOMK1V RN Halofantrine metabolism in microsomes in man: major role of CYP 3A4 and CYP 3A5. J Pharm Pharmacol. 1999 Apr;51(4):419-26. DMOMK1V RU https://www.ncbi.nlm.nih.gov/pubmed/?term=10385214 DMOMK1V DI DMOMK1V DMOMK1V DN Halofantrine DMOMK1V MI DECB0K3 DMOMK1V MN Cytochrome P450 2D6 (CYP2D6) DMOMK1V MT DME DMOMK1V MA Metabolism DMOMK1V RN Halofantrine and chloroquine inhibit CYP2D6 activity in healthy Zambians. Br J Clin Pharmacol. 1998 Mar;45(3):315-7. DMOMK1V RU https://www.ncbi.nlm.nih.gov/pubmed/?term=10896408 DMOMK1V DI DMOMK1V DMOMK1V DN Halofantrine DMOMK1V MI DE4LYSA DMOMK1V MN Cytochrome P450 3A4 (CYP3A4) DMOMK1V MT DME DMOMK1V MA Metabolism DMOMK1V RN Pharmacokinetic and pharmacodynamic interaction between grapefruit juice and halofantrine. Clin Pharmacol Ther. 2002 Nov;72(5):514-23. DMOMK1V RU https://www.ncbi.nlm.nih.gov/pubmed/?term=12426515 DMOMK1V DI DMOMK1V DMOMK1V DN Halofantrine DMOMK1V MI DEIBDNY DMOMK1V MN Cytochrome P450 3A5 (CYP3A5) DMOMK1V MT DME DMOMK1V MA Metabolism DMOMK1V RN Halofantrine metabolism in microsomes in man: major role of CYP 3A4 and CYP 3A5. J Pharm Pharmacol. 1999 Apr;51(4):419-26. DMOMK1V RU https://www.ncbi.nlm.nih.gov/pubmed/?term=10385214 DM96SE0 DI DM96SE0 DM96SE0 DN Haloperidol DM96SE0 MI DE6OQ3W DM96SE0 MN Cytochrome P450 1A1 (CYP1A1) DM96SE0 MT DME DM96SE0 MA Metabolism DM96SE0 RN In vitro characterization of the metabolism of haloperidol using recombinant cytochrome p450 enzymes and human liver microsomes. Drug Metab Dispos. 2001 Dec;29(12):1638-43. DM96SE0 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=11717183 DM96SE0 DI DM96SE0 DM96SE0 DN Haloperidol DM96SE0 MI DEJGDUW DM96SE0 MN Cytochrome P450 1A2 (CYP1A2) DM96SE0 MT DME DM96SE0 MA Metabolism DM96SE0 RN In vitro characterization of the metabolism of haloperidol using recombinant cytochrome p450 enzymes and human liver microsomes. Drug Metab Dispos. 2001 Dec;29(12):1638-43. DM96SE0 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=11717183 DM96SE0 DI DM96SE0 DM96SE0 DN Haloperidol DM96SE0 MI DE5IED8 DM96SE0 MN Cytochrome P450 2C9 (CYP2C9) DM96SE0 MT DME DM96SE0 MA Metabolism DM96SE0 RN In vitro characterization of the metabolism of haloperidol using recombinant cytochrome p450 enzymes and human liver microsomes. Drug Metab Dispos. 2001 Dec;29(12):1638-43. DM96SE0 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=11717183 DM96SE0 DI DM96SE0 DM96SE0 DN Haloperidol DM96SE0 MI DECB0K3 DM96SE0 MN Cytochrome P450 2D6 (CYP2D6) DM96SE0 MT DME DM96SE0 MA Metabolism DM96SE0 RN Use of antidepressant drugs in schizophrenic patients with depression. Encephale. 2006 Mar-Apr;32(2 Pt 1):263-9. DM96SE0 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=16910628 DM96SE0 DI DM96SE0 DM96SE0 DN Haloperidol DM96SE0 MI DE4LYSA DM96SE0 MN Cytochrome P450 3A4 (CYP3A4) DM96SE0 MT DME DM96SE0 MA Metabolism DM96SE0 RN Assessment of the contributions of CYP3A4 and CYP3A5 in the metabolism of the antipsychotic agent haloperidol to its potentially neurotoxic pyridinium metabolite and effect of antidepressants on the bioactivation pathway. Drug Metab Dispos. 2003 Mar;31(3):243-9. DM96SE0 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=12584149 DM96SE0 DI DM96SE0 DM96SE0 DN Haloperidol DM96SE0 MI DEIBDNY DM96SE0 MN Cytochrome P450 3A5 (CYP3A5) DM96SE0 MT DME DM96SE0 MA Metabolism DM96SE0 RN Assessment of the contributions of CYP3A4 and CYP3A5 in the metabolism of the antipsychotic agent haloperidol to its potentially neurotoxic pyridinium metabolite and effect of antidepressants on the bioactivation pathway. Drug Metab Dispos. 2003 Mar;31(3):243-9. DM96SE0 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=12584149 DM96SE0 DI DM96SE0 DM96SE0 DN Haloperidol DM96SE0 MI DERD86B DM96SE0 MN Cytochrome P450 3A7 (CYP3A7) DM96SE0 MT DME DM96SE0 MA Metabolism DM96SE0 RN Drug Interactions Flockhart Table DM96SE0 RU https://drug-interactions.medicine.iu.edu/Main-Table.aspx DM96SE0 DI DM96SE0 DM96SE0 DN Haloperidol DM96SE0 MI TTEX248 DM96SE0 MN Dopamine D2 receptor (D2R) DM96SE0 MT DTT DM96SE0 MA Antagonist DM96SE0 RN Dopaminergic synapses in the matrix of the ventrolateral striatum after chronic haloperidol treatment. Synapse. 2002 Aug;45(2):78-85. DM96SE0 RU https://pubmed.ncbi.nlm.nih.gov/12112400 DM96SE0 DI DM96SE0 DM96SE0 DN Haloperidol DM96SE0 MI DEGTFWK DM96SE0 MN Mephenytoin 4-hydroxylase (CYP2C19) DM96SE0 MT DME DM96SE0 MA Metabolism DM96SE0 RN In vitro characterization of the metabolism of haloperidol using recombinant cytochrome p450 enzymes and human liver microsomes. Drug Metab Dispos. 2001 Dec;29(12):1638-43. DM96SE0 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=11717183 DM96SE0 DI DM96SE0 DM96SE0 DN Haloperidol DM96SE0 MI DTUGYRD DM96SE0 MN P-glycoprotein 1 (ABCB1) DM96SE0 MT DTP DM96SE0 MA Substrate DM96SE0 RN Identification of P-glycoprotein substrates and inhibitors among psychoactive compounds--implications for pharmacokinetics of selected substrates. J Pharm Pharmacol. 2004 Aug;56(8):967-75. DM96SE0 RU http://www.ncbi.nlm.nih.gov/pubmed/15285840 DM96SE0 DI DM96SE0 DM96SE0 DN Haloperidol DM96SE0 MI DE85D2P DM96SE0 MN UDP-glucuronosyltransferase 1A9 (UGT1A9) DM96SE0 MT DME DM96SE0 MA Metabolism DM96SE0 RN Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. DM96SE0 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=19515014 DMH4IVU DI DMH4IVU DMH4IVU DN Haloprogin DMH4IVU MI TTAH0B3 DMH4IVU MN Fungal Cell membrane (Fung CM) DMH4IVU MT DTT DMH4IVU MA Binder DMH4IVU RN Haloprogin: mode of action studies in Candida albicans. Can J Microbiol. 1974 Sep;20(9):1241-5. DMH4IVU RU https://pubmed.ncbi.nlm.nih.gov/4608935 DM80OZ5 DI DM80OZ5 DM80OZ5 DN Halothane DM80OZ5 MI DEJVYAZ DM80OZ5 MN Cytochrome P450 2A6 (CYP2A6) DM80OZ5 MT DME DM80OZ5 MA Metabolism DM80OZ5 RN Halothane-dependent lipid peroxidation in human liver microsomes is catalyzed by cytochrome P4502A6 (CYP2A6). Anesthesiology. 2001 Aug;95(2):509-14. DM80OZ5 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=11506127 DM80OZ5 DI DM80OZ5 DM80OZ5 DN Halothane DM80OZ5 MI DEPKLMQ DM80OZ5 MN Cytochrome P450 2B6 (CYP2B6) DM80OZ5 MT DME DM80OZ5 MA Metabolism DM80OZ5 RN Bupropion and 4-OH-bupropion pharmacokinetics in relation to genetic polymorphisms in CYP2B6. Pharmacogenetics. 2003 Oct;13(10):619-26. DM80OZ5 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=14515060 DM80OZ5 DI DM80OZ5 DM80OZ5 DN Halothane DM80OZ5 MI DE5IED8 DM80OZ5 MN Cytochrome P450 2C9 (CYP2C9) DM80OZ5 MT DME DM80OZ5 MA Metabolism DM80OZ5 RN Human reductive halothane metabolism in vitro is catalyzed by cytochrome P450 2A6 and 3A4. Drug Metab Dispos. 1996 Sep;24(9):976-83. DM80OZ5 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=8886607 DM80OZ5 DI DM80OZ5 DM80OZ5 DN Halothane DM80OZ5 MI DECB0K3 DM80OZ5 MN Cytochrome P450 2D6 (CYP2D6) DM80OZ5 MT DME DM80OZ5 MA Metabolism DM80OZ5 RN Summary of information on human CYP enzymes: human P450 metabolism data. Drug Metab Rev. 2002 Feb-May;34(1-2):83-448. DM80OZ5 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=11996015 DM80OZ5 DI DM80OZ5 DM80OZ5 DN Halothane DM80OZ5 MI DEVDYN7 DM80OZ5 MN Cytochrome P450 2E1 (CYP2E1) DM80OZ5 MT DME DM80OZ5 MA Metabolism DM80OZ5 RN Concordance between trifluoroacetic acid and hepatic protein trifluoroacetylation after disulfiram inhibition of halothane metabolism in rats. Acta Anaesthesiol Scand. 2003 Jul;47(6):765-70. DM80OZ5 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=12803597 DM80OZ5 DI DM80OZ5 DM80OZ5 DN Halothane DM80OZ5 MI DE4LYSA DM80OZ5 MN Cytochrome P450 3A4 (CYP3A4) DM80OZ5 MT DME DM80OZ5 MA Metabolism DM80OZ5 RN Human reductive halothane metabolism in vitro is catalyzed by cytochrome P450 2A6 and 3A4. Drug Metab Dispos. 1996 Sep;24(9):976-83. DM80OZ5 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=8886607 DM80OZ5 DI DM80OZ5 DM80OZ5 DN Halothane DM80OZ5 MI TTAN6JD DM80OZ5 MN Glutamate receptor AMPA (GRIA) DM80OZ5 MT DTT DM80OZ5 MA Antagonist DM80OZ5 RN Reduced inhibition of cortical glutamate and GABA release by halothane in mice lacking the K+ channel, TREK-1. Br J Pharmacol. 2007 Nov;152(6):939-45. DM80OZ5 RU https://pubmed.ncbi.nlm.nih.gov/17828284 DM80OZ5 DI DM80OZ5 DM80OZ5 DN Halothane DM80OZ5 MI DE9A2LB DM80OZ5 MN Microsomal cytochrome MCB5 (CYB5A) DM80OZ5 MT DME DM80OZ5 MA Metabolism DM80OZ5 RN Modulation of the reductive metabolism of halothane by microsomal cytochrome b5 in rat liver. Biochim Biophys Acta. 1987 Dec 7;926(3):231-8. DM80OZ5 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=3689822 DMN0S1G DI DMN0S1G DMN0S1G DN HEGF DMN0S1G MI TTGKNB4 DMN0S1G MN Epidermal growth factor receptor (EGFR) DMN0S1G MT DTT DMN0S1G MA Activator DMN0S1G RN Emerging drugs for diabetic foot ulcers. Expert Opin Emerg Drugs. 2006 Nov;11(4):709-24. DMN0S1G RU https://pubmed.ncbi.nlm.nih.gov/17064227 DMEVXY6 DI DMEVXY6 DMEVXY6 DN Heparin Calcium DMEVXY6 MI TT4QPUL DMEVXY6 MN Antithrombin-III (ATIII) DMEVXY6 MT DTT DMEVXY6 MA Modulator DMEVXY6 RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. DMEVXY6 RU https://www.fda.gov/ DM9KHZL DI DM9KHZL DM9KHZL DN Heparin Sodium DM9KHZL MI TT4QPUL DM9KHZL MN Antithrombin-III (ATIII) DM9KHZL MT DTT DM9KHZL MA Modulator DM9KHZL RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2632). DM9KHZL RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2632 DMOB2F3 DI DMOB2F3 DMOB2F3 DN Heptabarbital DMOB2F3 MI TTAN6JD DMOB2F3 MN Glutamate receptor AMPA (GRIA) DMOB2F3 MT DTT DMOB2F3 MA Antagonist DMOB2F3 RN A computer program using disposition decomposition analysis in pharmacodynamics. Biopharm Drug Dispos. 1997 Jan;18(1):9-15. DMOB2F3 RU https://pubmed.ncbi.nlm.nih.gov/9008265 DM6YWBF DI DM6YWBF DM6YWBF DN Herbimycin A DM6YWBF MI TT6PKBN DM6YWBF MN Proto-oncogene c-Src (SRC) DM6YWBF MT DTT DM6YWBF MA Inhibitor DM6YWBF RN In vivo antitumor activity of herbimycin A, a tyrosine kinase inhibitor, targeted against BCR/ABL oncoprotein in mice bearing BCR/ABL-transfected cells. Leuk Res. 1994 Nov;18(11):867-73. DM6YWBF RU https://pubmed.ncbi.nlm.nih.gov/7967714 DMDBWHY DI DMDBWHY DMDBWHY DN Heroin diacetylmorphine DMDBWHY MI DEQ2BAJ DMDBWHY MN Acetylcholinesterase (ACHE) DMDBWHY MT DME DMDBWHY MA Metabolism DMDBWHY RN Kinetic characterization of cholinesterases and a therapeutically valuable cocaine hydrolase for their catalytic activities against heroin and its metabolite 6-monoacetylmorphine. Chem Biol Interact. 2018 Sep 25;293:107-114. DMDBWHY RU https://www.ncbi.nlm.nih.gov/pubmed/?term=30080993 DMKER83 DI DMKER83 DMKER83 DN Hesperetin DMKER83 MI DTI7UX6 DMKER83 MN Breast cancer resistance protein (ABCG2) DMKER83 MT DTP DMKER83 MA Substrate DMKER83 RN Interaction of the breast cancer resistance protein with plant polyphenols. Biochem Biophys Res Commun. 2004 Apr 23;317(1):269-75. DMKER83 RU https://doi.org/10.1016/j.bbrc.2004.03.040 DMKER83 DI DMKER83 DMKER83 DN Hesperetin DMKER83 MI DEJGDUW DMKER83 MN Cytochrome P450 1A2 (CYP1A2) DMKER83 MT DME DMKER83 MA Metabolism DMKER83 RN In vitro investigation of cytochrome P450-mediated metabolism of dietary flavonoids. Food Chem Toxicol. 2002 May;40(5):609-16. DMKER83 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=11955666 DMKER83 DI DMKER83 DMKER83 DN Hesperetin DMKER83 MI TTF8P9I DMKER83 MN Diacylglycerol acyltransferase 1 (DGAT1) DMKER83 MT DTT DMKER83 MA Inhibitor DMKER83 RN In vitro inhibition of diacylglycerol acyltransferase by prenylflavonoids from Sophora flavescens. Planta Med. 2004 Mar;70(3):258-60. DMKER83 RU https://pubmed.ncbi.nlm.nih.gov/15114505 DMI5DW1 DI DMI5DW1 DMI5DW1 DN Hesperidin DMI5DW1 MI TT4FDG6 DMI5DW1 MN Voltage-gated calcium channel alpha Cav2.2 (CACNA1B) DMI5DW1 MT DTT DMI5DW1 MA Inhibitor DMI5DW1 RN In silico identification and biochemical evaluation of novel inhibitors of NRH:quinone oxidoreductase 2 (NQO2). Bioorg Med Chem Lett. 2010 Dec 15;20(24):7331-6. DMI5DW1 RU https://pubmed.ncbi.nlm.nih.gov/21074425 DMPXITB DI DMPXITB DMPXITB DN Hetacillin DMPXITB MI TTJP4SM DMPXITB MN Bacterial Penicillin binding protein (Bact PBP) DMPXITB MT DTT DMPXITB MA Modulator DMPXITB RN JBioWH: an open-source Java framework for bioinformatics data integration.Database (Oxford).2013 Jul 11;2013:bat051. DMPXITB RU https://www.ncbi.nlm.nih.gov/pubmed/23846595 DMGUC9T DI DMGUC9T DMGUC9T DN HEV-239 DMGUC9T MI TT3J5ZI DMGUC9T MN Cell mediated immunity response (CMIR) DMGUC9T MT DTT DMGUC9T RN The development of a recombinant hepatitis E vaccine HEV 239. Hum Vaccin Immunother. 2015;11(4):908-14. DMGUC9T RU https://pubmed.ncbi.nlm.nih.gov/25714510 DMLKSE0 DI DMLKSE0 DMLKSE0 DN Hexachlorophene DMLKSE0 MI TTAO7YK DMLKSE0 MN Plasmodium Glutamate dehydrogenase (Malaria gdh) DMLKSE0 MT DTT DMLKSE0 MA Inhibitor DMLKSE0 RN Novel inhibitors complexed with glutamate dehydrogenase: allosteric regulation by control of protein dynamics. J Biol Chem. 2009 Aug 21;284(34):22988-3000. DMLKSE0 RU https://pubmed.ncbi.nlm.nih.gov/19531491 DMFY307 DI DMFY307 DMFY307 DN Hexafluronium bromide DMFY307 MI TTEB0GD DMFY307 MN Cholinesterase (BCHE) DMFY307 MT DTT DMFY307 MA Inhibitor DMFY307 RN Synergistic effect of acidosis and succinylcholine-induced hyperkalemia in spinal cord transected rats. Acta Anaesthesiol Scand. 1984 Feb;28(1):87-90. DMFY307 RU https://pubmed.ncbi.nlm.nih.gov/6711267 DMQ314B DI DMQ314B DMQ314B DN Hexobarbital DMQ314B MI DEJGDUW DMQ314B MN Cytochrome P450 1A2 (CYP1A2) DMQ314B MT DME DMQ314B MA Metabolism DMQ314B RN Cytochrome P450 isozymes involved in propranolol metabolism in human liver microsomes. The role of CYP2D6 as ring-hydroxylase and CYP1A2 as N-desisopropylase. Drug Metab Dispos. 1994 Nov-Dec;22(6):909-15. DMQ314B RU https://www.ncbi.nlm.nih.gov/pubmed/?term=7895609 DMQ314B DI DMQ314B DMQ314B DN Hexobarbital DMQ314B MI DE5IED8 DMQ314B MN Cytochrome P450 2C9 (CYP2C9) DMQ314B MT DME DMQ314B MA Metabolism DMQ314B RN Summary of information on human CYP enzymes: human P450 metabolism data. Drug Metab Rev. 2002 Feb-May;34(1-2):83-448. DMQ314B RU https://www.ncbi.nlm.nih.gov/pubmed/?term=11996015 DMQ314B DI DMQ314B DMQ314B DN Hexobarbital DMQ314B MI DE4LYSA DMQ314B MN Cytochrome P450 3A4 (CYP3A4) DMQ314B MT DME DMQ314B MA Metabolism DMQ314B RN Cytochrome P450 isozymes involved in propranolol metabolism in human liver microsomes. The role of CYP2D6 as ring-hydroxylase and CYP1A2 as N-desisopropylase. Drug Metab Dispos. 1994 Nov-Dec;22(6):909-15. DMQ314B RU https://www.ncbi.nlm.nih.gov/pubmed/?term=7895609 DMQ314B DI DMQ314B DMQ314B DN Hexobarbital DMQ314B MI TT1MPAY DMQ314B MN GABA(A) receptor alpha-1 (GABRA1) DMQ314B MT DTT DMQ314B MA Antagonist DMQ314B RN DrugBank: a knowledgebase for drugs, drug actions and drug targets. Nucleic Acids Res. 2008 Jan;36(Database issue):D901-6. DMQ314B RU https://pubmed.ncbi.nlm.nih.gov/18048412 DMQ314B DI DMQ314B DMQ314B DN Hexobarbital DMQ314B MI DEGTFWK DMQ314B MN Mephenytoin 4-hydroxylase (CYP2C19) DMQ314B MT DME DMQ314B MA Metabolism DMQ314B RN Stereoselective hexobarbital 3'-hydroxylation by CYP2C19 expressed in yeast cells and the roles of amino acid residues at positions 300 and 476. Chirality. 2007 Jul;19(7):550-8. DMQ314B RU https://www.ncbi.nlm.nih.gov/pubmed/?term=17487889 DMQ314B DI DMQ314B DMQ314B DN Hexobarbital DMQ314B MI DE073H6 DMQ314B MN Prostaglandin G/H synthase 1 (COX-1) DMQ314B MT DME DMQ314B MA Metabolism DMQ314B RN Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. DMQ314B RU https://www.ncbi.nlm.nih.gov/pubmed/?term=19515014 DMEADRK DI DMEADRK DMEADRK DN Hexylcaine DMEADRK MI TTZOVE0 DMEADRK MN Voltage-gated sodium channel alpha Nav1.5 (SCN5A) DMEADRK MT DTT DMEADRK MA Blocker DMEADRK RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMEADRK RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMV7IM6 DI DMV7IM6 DMV7IM6 DN Histamine Phosphate DMV7IM6 MI TT7CXIM DMV7IM6 MN Histamine receptor (HR) DMV7IM6 MT DTT DMV7IM6 MA Modulator DMV7IM6 RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. DMV7IM6 RU https://www.fda.gov/ DMGBPSH DI DMGBPSH DMGBPSH DN Homatropine Methylbromide DMGBPSH MI TTH18TF DMGBPSH MN Muscarinic acetylcholine receptor M5 (CHRM5) DMGBPSH MT DTT DMGBPSH MA Antagonist DMGBPSH RN Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. DMGBPSH RU https://pubmed.ncbi.nlm.nih.gov/17016423 DM78G6F DI DM78G6F DM78G6F DN HTF 919 DM78G6F MI TT07C3Y DM78G6F MN 5-HT 4 receptor (HTR4) DM78G6F MT DTT DM78G6F MA Agonist DM78G6F RN 5-Hydroxytryptamine mediated contractions in isolated preparations of equine ileum and pelvic flexure: pharmacological characterization of a new 5-HT(4) agonist. J Vet Pharmacol Ther. 2002 Feb;25(1):49-58. DM78G6F RU https://pubmed.ncbi.nlm.nih.gov/11874527 DMA5OBU DI DMA5OBU DMA5OBU DN Human neutral insulin DMA5OBU MI TTCBFJO DMA5OBU MN Insulin receptor (INSR) DMA5OBU MT DTT DMA5OBU MA Binder DMA5OBU RN Knockouts model the 100 best-selling drugs--will they model the next 100 Nat Rev Drug Discov. 2003 Jan;2(1):38-51. DMA5OBU RU https://pubmed.ncbi.nlm.nih.gov/12509758 DMPHVQ1 DI DMPHVQ1 DMPHVQ1 DN Human prothrombin complex concentrate DMPHVQ1 MI TT6L509 DMPHVQ1 MN Coagulation factor IIa (F2) DMPHVQ1 MT DTT DMPHVQ1 MA Modulator DMPHVQ1 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2362). DMPHVQ1 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2362 DMMAWLU DI DMMAWLU DMMAWLU DN Huperzine A DMMAWLU MI TT1RS9F DMMAWLU MN Acetylcholinesterase (AChE) DMMAWLU MT DTT DMMAWLU MA Inhibitor DMMAWLU RN Huperzine A attenuates cognitive deficits and brain injury in neonatal rats after hypoxia-ischemia. Brain Res. 2002 Sep 13;949(1-2):162-70. DMMAWLU RU https://pubmed.ncbi.nlm.nih.gov/12213312 DMMAWLU DI DMMAWLU DMMAWLU DN Huperzine A DMMAWLU MI TT9IK2Z DMMAWLU MN N-methyl-D-aspartate receptor (NMDAR) DMMAWLU MT DTT DMMAWLU MA Antagonist DMMAWLU RN Progress report on new antiepileptic drugs: a summary of the Ninth Eilat Conference (EILAT IX). Epilepsy Res. 2009 Jan;83(1):1-43. DMMAWLU RU https://pubmed.ncbi.nlm.nih.gov/19008076 DMX8M26 DI DMX8M26 DMX8M26 DN Hyaluronate sodium DMX8M26 MI DEH31BC DMX8M26 MN Hyaluronate lyase (hyaL) DMX8M26 MT DME DMX8M26 MA Metabolism DMX8M26 RN A bacterial ABC transporter enables import of mammalian host glycosaminoglycans. Sci Rep. 2017 Apr 21;7(1):1069. DMX8M26 RU https://pubmed.ncbi.nlm.nih.gov/28432302 DMX8M26 DI DMX8M26 DMX8M26 DN Hyaluronate sodium DMX8M26 MI TTG8DNU DMX8M26 MN Hyaluronic acid receptor (LYVE1) DMX8M26 MT DTT DMX8M26 MA Modulator DMX8M26 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4954). DMX8M26 RU http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=4954 DMX8M26 DI DMX8M26 DMX8M26 DN Hyaluronate sodium DMX8M26 MI DEWP153 DMX8M26 MN Hyaluronidase (hyl) DMX8M26 MT DME DMX8M26 MA Metabolism DMX8M26 RN A novel hyaluronidase produced by Bacillus sp. A50. PLoS One. 2014 Apr 15;9(4):e94156. DMX8M26 RU https://pubmed.ncbi.nlm.nih.gov/24736576 DMETWAU DI DMETWAU DMETWAU DN Hyaluronidase (ovine) DMETWAU MI TTYTVXF DMETWAU MN Hyaluronic acid (HA) DMETWAU MT DTT DMETWAU MA Modulator DMETWAU RN Safety results of two phase III trials of an intravitreous injection of highly purified ovine hyaluronidase (Vitrase) for the management of vitreous hemorrhage. Am J Ophthalmol. 2005 Oct;140(4):585-97. DMETWAU RU https://pubmed.ncbi.nlm.nih.gov/16226510 DMU8JGH DI DMU8JGH DMU8JGH DN Hydralazine DMU8JGH MI TT7HC21 DMU8JGH MN Membrane copper amine oxidase (AOC3) DMU8JGH MT DTT DMU8JGH MA Modulator DMU8JGH RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. DMU8JGH RU https://www.fda.gov/ DMU8JGH DI DMU8JGH DMU8JGH DN Hydralazine DMU8JGH MI DE7OAB3 DMU8JGH MN N-acetyltransferase 1 (NAT1) DMU8JGH MT DME DMU8JGH MA Metabolism DMU8JGH RN N-acetyltransferase 2 genotype-dependent N-acetylation of hydralazine in human hepatocytes. Drug Metab Dispos. 2017 Dec;45(12):1276-1281. DMU8JGH RU https://www.ncbi.nlm.nih.gov/pubmed/?term=29018032 DMU8JGH DI DMU8JGH DMU8JGH DN Hydralazine DMU8JGH MI DER7TA0 DMU8JGH MN N-acetyltransferase 2 (NAT2) DMU8JGH MT DME DMU8JGH MA Metabolism DMU8JGH RN N-acetyltransferase 2 genotype-dependent N-acetylation of hydralazine in human hepatocytes. Drug Metab Dispos. 2017 Dec;45(12):1276-1281. DMU8JGH RU https://www.ncbi.nlm.nih.gov/pubmed/?term=29018032 DMU8JGH DI DMU8JGH DMU8JGH DN Hydralazine DMU8JGH MI DEZV4AP DMU8JGH MN RNA cytidine acetyltransferase (hALP) DMU8JGH MT DME DMU8JGH MA Metabolism DMU8JGH RN Prizidilol, an antihypertensive with precapillary vasodilator and beta-adrenoceptor blocking actions, in primary hypertension. Clin Pharmacol Ther. 1981 May;29(5):588-93. DMU8JGH RU https://www.ncbi.nlm.nih.gov/pubmed/?term=6111409 DMUSZHD DI DMUSZHD DMUSZHD DN Hydrochlorothiazide DMUSZHD MI TTL69WB DMUSZHD MN Angiotensin-converting enzyme (ACE) DMUSZHD MT DTT DMUSZHD MA Modulator DMUSZHD RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. DMUSZHD RU https://www.fda.gov/ DMQ2JO5 DI DMQ2JO5 DMQ2JO5 DN Hydrocodone DMQ2JO5 MI TTKWM86 DMQ2JO5 MN Opioid receptor mu (MOP) DMQ2JO5 MT DTT DMQ2JO5 MA Modulator DMQ2JO5 RN Clinical pipeline report, company report or official report of kempharm. DMQ2JO5 RU http://www.kempharm.com/pages/pipeline/pain.php DMIAPBE DI DMIAPBE DMIAPBE DN Hydrocodone bitartrate DMIAPBE MI DEPKLMQ DMIAPBE MN Cytochrome P450 2B6 (CYP2B6) DMIAPBE MT DME DMIAPBE MA Metabolism DMIAPBE RN FDA label of Hydrocodone bitartrate. The 2020 official website of the U.S. Food and Drug Administration. DMIAPBE RU https://www.accessdata.fda.gov/drugsatfda_docs/label/2018/206627s007s008lbl.pdf DMIAPBE DI DMIAPBE DMIAPBE DN Hydrocodone bitartrate DMIAPBE MI DECB0K3 DMIAPBE MN Cytochrome P450 2D6 (CYP2D6) DMIAPBE MT DME DMIAPBE MA Metabolism DMIAPBE RN The effect of CYP2D6 drug-drug interactions on hydrocodone effectiveness. Acad Emerg Med. 2014 Aug;21(8):879-85. DMIAPBE RU https://www.ncbi.nlm.nih.gov/pubmed/?term=25156930 DMIAPBE DI DMIAPBE DMIAPBE DN Hydrocodone bitartrate DMIAPBE MI DE4LYSA DMIAPBE MN Cytochrome P450 3A4 (CYP3A4) DMIAPBE MT DME DMIAPBE MA Metabolism DMIAPBE RN The effect of CYP2D6 drug-drug interactions on hydrocodone effectiveness. Acad Emerg Med. 2014 Aug;21(8):879-85. DMIAPBE RU https://www.ncbi.nlm.nih.gov/pubmed/?term=25156930 DMIAPBE DI DMIAPBE DMIAPBE DN Hydrocodone bitartrate DMIAPBE MI DEYGVN4 DMIAPBE MN UDP-glucuronosyltransferase 1A1 (UGT1A1) DMIAPBE MT DME DMIAPBE MA Metabolism DMIAPBE RN Pharmacokinetic drug interactions of morphine, codeine, and their derivatives: theory and clinical reality, Part II. Psychosomatics. 2003 Nov-Dec;44(6):515-20. DMIAPBE RU https://www.ncbi.nlm.nih.gov/pubmed/?term=14597688 DM8K1XO DI DM8K1XO DM8K1XO DN Hydrocortamate DM8K1XO MI TTYRL6O DM8K1XO MN Glucocorticoid receptor (NR3C1) DM8K1XO MT DTT DM8K1XO MA Modulator DM8K1XO RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. DM8K1XO RU https://www.fda.gov/ DMGEMB7 DI DMGEMB7 DMGEMB7 DN Hydrocortisone DMGEMB7 MI DE6TYUK DMGEMB7 MN Aldosterone synthase (CYP11B2) DMGEMB7 MT DME DMGEMB7 MA Metabolism DMGEMB7 RN Studies on the origin of circulating 18-hydroxycortisol and 18-oxocortisol in normal human subjects. J Clin Endocrinol Metab. 2004 Sep;89(9):4628-33. DMGEMB7 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=15356073 DMGEMB7 DI DMGEMB7 DMGEMB7 DN Hydrocortisone DMGEMB7 MI DE4LYSA DMGEMB7 MN Cytochrome P450 3A4 (CYP3A4) DMGEMB7 MT DME DMGEMB7 MA Metabolism DMGEMB7 RN Regulation of the CYP3A4 gene by hydrocortisone and xenobiotics: role of the glucocorticoid and pregnane X receptors. Drug Metab Dispos. 2000 May;28(5):493-6. DMGEMB7 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=10772626 DMGEMB7 DI DMGEMB7 DMGEMB7 DN Hydrocortisone DMGEMB7 MI DEIBDNY DMGEMB7 MN Cytochrome P450 3A5 (CYP3A5) DMGEMB7 MT DME DMGEMB7 MA Metabolism DMGEMB7 RN CYP3A5 genotype is associated with elevated blood pressure. Pharmacogenet Genomics. 2005 Oct;15(10):737-41. DMGEMB7 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=16141800 DMGEMB7 DI DMGEMB7 DMGEMB7 DN Hydrocortisone DMGEMB7 MI DERD86B DMGEMB7 MN Cytochrome P450 3A7 (CYP3A7) DMGEMB7 MT DME DMGEMB7 MA Metabolism DMGEMB7 RN Steroid hydroxylation by human fetal CYP3A7 and human NADPH-cytochrome P450 reductase coexpressed in insect cells using baculovirus. Res Commun Mol Pathol Pharmacol. 1998 Apr;100(1):15-28. DMGEMB7 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=9644715 DMGEMB7 DI DMGEMB7 DMGEMB7 DN Hydrocortisone DMGEMB7 MI TTYRL6O DMGEMB7 MN Glucocorticoid receptor (NR3C1) DMGEMB7 MT DTT DMGEMB7 MA Modulator DMGEMB7 RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. DMGEMB7 RU https://www.fda.gov/ DMGEMB7 DI DMGEMB7 DMGEMB7 DN Hydrocortisone DMGEMB7 MI DTUGYRD DMGEMB7 MN P-glycoprotein 1 (ABCB1) DMGEMB7 MT DTP DMGEMB7 MA Substrate DMGEMB7 RN Oral and inhaled corticosteroids: differences in P-glycoprotein (ABCB1) mediated efflux. Toxicol Appl Pharmacol. 2012 May 1;260(3):294-302. DMGEMB7 RU https://doi.org/10.1016/j.taap.2012.03.008 DMGEMB7 DI DMGEMB7 DMGEMB7 DN Hydrocortisone DMGEMB7 MI DEPE0RD DMGEMB7 MN Steroid 11-beta-hydroxylase (CYP11B1) DMGEMB7 MT DME DMGEMB7 MA Metabolism DMGEMB7 RN Studies on the origin of circulating 18-hydroxycortisol and 18-oxocortisol in normal human subjects. J Clin Endocrinol Metab. 2004 Sep;89(9):4628-33. DMGEMB7 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=15356073 DMVPUQI DI DMVPUQI DMVPUQI DN Hydroflumethiazide DMVPUQI MI TTS087L DMVPUQI MN Solute carrier family 12 member 1 (SLC12A1) DMVPUQI MT DTT DMVPUQI MA Blocker DMVPUQI RN DrugBank: a knowledgebase for drugs, drug actions and drug targets. Nucleic Acids Res. 2008 Jan;36(Database issue):D901-6. DMVPUQI RU https://pubmed.ncbi.nlm.nih.gov/18048412 DM1NG5W DI DM1NG5W DM1NG5W DN Hydrogen peroxide DM1NG5W MI DE1XPGH DM1NG5W MN Catalase (CAT) DM1NG5W MT DME DM1NG5W MA Metabolism DM1NG5W RN Catalase and glutathione peroxidase are equally active in detoxification of hydrogen peroxide in human erythrocytes. Blood. 1989 Jan;73(1):334-9. DM1NG5W RU https://www.ncbi.nlm.nih.gov/pubmed/?term=2491951 DM1NG5W DI DM1NG5W DM1NG5W DN Hydrogen peroxide DM1NG5W MI DESZ5G9 DM1NG5W MN Cellular glutathione peroxidase (GPX1) DM1NG5W MT DME DM1NG5W MA Metabolism DM1NG5W RN Catalase and glutathione peroxidase are equally active in detoxification of hydrogen peroxide in human erythrocytes. Blood. 1989 Jan;73(1):334-9. DM1NG5W RU https://www.ncbi.nlm.nih.gov/pubmed/?term=2491951 DM1NG5W DI DM1NG5W DM1NG5W DN Hydrogen peroxide DM1NG5W MI DE9QHP6 DM1NG5W MN Cytochrome P450 1B1 (CYP1B1) DM1NG5W MT DME DM1NG5W MA Metabolism DM1NG5W RN NADPH- and hydroperoxide-supported 17beta-estradiol hydroxylation catalyzed by a variant form (432L, 453S) of human cytochrome P450 1B1. J Steroid Biochem Mol Biol. 2000 Sep;74(1-2):11-8. DM1NG5W RU https://www.ncbi.nlm.nih.gov/pubmed/?term=11074351 DM1NG5W DI DM1NG5W DM1NG5W DN Hydrogen peroxide DM1NG5W MI DECB0K3 DM1NG5W MN Cytochrome P450 2D6 (CYP2D6) DM1NG5W MT DME DM1NG5W MA Metabolism DM1NG5W RN Engineering of cytochrome P450 3A4 for enhanced peroxide-mediated substrate oxidation using directed evolution and site-directed mutagenesis. Drug Metab Dispos. 2006 Dec;34(12):1958-65. DM1NG5W RU https://www.ncbi.nlm.nih.gov/pubmed/?term=16987939 DM1NG5W DI DM1NG5W DM1NG5W DN Hydrogen peroxide DM1NG5W MI TTELIN2 DM1NG5W MN PTPN1 messenger RNA (PTPN1 mRNA) DM1NG5W MT DTT DM1NG5W MA Inhibitor DM1NG5W RN Periodinates: a new class of protein tyrosine phosphatase inhibitors. Bioorg Med Chem Lett. 1999 Feb 8;9(3):353-6. DM1NG5W RU https://pubmed.ncbi.nlm.nih.gov/10091683 DMHP21E DI DMHP21E DMHP21E DN Hydromorphone DMHP21E MI DE5IED8 DMHP21E MN Cytochrome P450 2C9 (CYP2C9) DMHP21E MT DME DMHP21E MA Metabolism DMHP21E RN Role of individual human cytochrome P450 enzymes in the in vitro metabolism of hydromorphone. Xenobiotica. 2004 Apr;34(4):335-44.; DMHP21E RU https://www.ncbi.nlm.nih.gov/pubmed/?term=15268978 DMHP21E DI DMHP21E DMHP21E DN Hydromorphone DMHP21E MI DECB0K3 DMHP21E MN Cytochrome P450 2D6 (CYP2D6) DMHP21E MT DME DMHP21E MA Metabolism DMHP21E RN Effect of cytochrome P450 2D1 inhibition on hydrocodone metabolism and its behavioral consequences in rats. J Pharmacol Exp Ther. 1997 Mar;280(3):1374-82. DMHP21E RU https://www.ncbi.nlm.nih.gov/pubmed/?term=9067326 DMHP21E DI DMHP21E DMHP21E DN Hydromorphone DMHP21E MI DE4LYSA DMHP21E MN Cytochrome P450 3A4 (CYP3A4) DMHP21E MT DME DMHP21E MA Metabolism DMHP21E RN Capillary electrophoresis contributions to the hydromorphone metabolism in man. Electrophoresis. 2006 Jun;27(12):2444-57. DMHP21E RU https://www.ncbi.nlm.nih.gov/pubmed/?term=16718649 DMHP21E DI DMHP21E DMHP21E DN Hydromorphone DMHP21E MI TT27RFC DMHP21E MN Opioid receptor delta (OPRD1) DMHP21E MT DTT DMHP21E MA Binder DMHP21E RN Identification of opioid ligands possessing mixed micro agonist/delta antagonist activity among pyridomorphinans derived from naloxone, oxymorphone, and hydromorphone [correction of hydropmorphone]. J Med Chem. 2004 Mar 11;47(6):1400-12. DMHP21E RU https://pubmed.ncbi.nlm.nih.gov/14998329 DMHP21E DI DMHP21E DMHP21E DN Hydromorphone DMHP21E MI TTKWM86 DMHP21E MN Opioid receptor mu (MOP) DMHP21E MT DTT DMHP21E MA Inhibitor DMHP21E RN Clinical pipeline report, company report or official report of signaturerx. DMHP21E RU http://www.signaturerx.com/view.cfm/59/Abuse-Resistant-Opioids DMHP21E DI DMHP21E DMHP21E DN Hydromorphone DMHP21E MI DEYGVN4 DMHP21E MN UDP-glucuronosyltransferase 1A1 (UGT1A1) DMHP21E MT DME DMHP21E MA Metabolism DMHP21E RN Is maternal opioid use hazardous to breast-fed infants? Clin Toxicol (Phila). 2012 Jan;50(1):1-14. DMHP21E RU https://www.ncbi.nlm.nih.gov/pubmed/?term=22148986 DMHP21E DI DMHP21E DMHP21E DN Hydromorphone DMHP21E MI DEF2WXN DMHP21E MN UDP-glucuronosyltransferase 1A3 (UGT1A3) DMHP21E MT DME DMHP21E MA Metabolism DMHP21E RN Opioid therapies and cytochrome p450 interactions. J Pain Symptom Manage. 2012 Dec;44(6 Suppl):S4-14. DMHP21E RU https://www.ncbi.nlm.nih.gov/pubmed/?term=23218233 DMHP21E DI DMHP21E DMHP21E DN Hydromorphone DMHP21E MI DEB3CV1 DMHP21E MN UDP-glucuronosyltransferase 2B7 (UGT2B7) DMHP21E MT DME DMHP21E MA Metabolism DMHP21E RN Opioid therapies and cytochrome p450 interactions. J Pain Symptom Manage. 2012 Dec;44(6 Suppl):S4-14. DMHP21E RU https://www.ncbi.nlm.nih.gov/pubmed/?term=23218233 DM6AVR4 DI DM6AVR4 DM6AVR4 DN Hydroquinone DM6AVR4 MI DE4LYSA DM6AVR4 MN Cytochrome P450 3A4 (CYP3A4) DM6AVR4 MT DME DM6AVR4 MA Metabolism DM6AVR4 RN Metabolism of (S)-5,6-difluoro-4-cyclopropylethynyl-4-trifluoromethyl-3, 4-dihydro-2(1H)-quinazolinone, a non-nucleoside reverse transcriptase inhibitor, in human liver microsomes. Metabolic activation and enzyme kinetics. Drug Metab Dispos. 2003 Jan;31(1):122-32. DM6AVR4 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=12485961 DM6AVR4 DI DM6AVR4 DM6AVR4 DN Hydroquinone DM6AVR4 MI DEQUXZ5 DM6AVR4 MN Fumarate reductase flavoprotein (frdA) DM6AVR4 MT DME DM6AVR4 MA Metabolism DM6AVR4 RN Wolinella succinogenes quinol:fumarate reductase and its comparison to E. coli succinate:quinone reductase. FEBS Lett. 2003 Nov 27;555(1):21-8. DM6AVR4 RU https://pubmed.ncbi.nlm.nih.gov/14630313 DM6AVR4 DI DM6AVR4 DM6AVR4 DN Hydroquinone DM6AVR4 MI TT38RM1 DM6AVR4 MN Glycoprotein IIb/IIIa receptor (GPIIb/IIIa) DM6AVR4 MT DTT DM6AVR4 MA Antagonist DM6AVR4 RN Accutin, a new disintegrin, inhibits angiogenesis in vitro and in vivo by acting as integrin alphavbeta3 antagonist and inducing apoptosis. Blood. 1998 Nov 1;92(9):3268-76. DM6AVR4 RU https://pubmed.ncbi.nlm.nih.gov/9787163 DM6AVR4 DI DM6AVR4 DM6AVR4 DN Hydroquinone DM6AVR4 MI TTULVH8 DM6AVR4 MN Tyrosinase (TYR) DM6AVR4 MT DTT DM6AVR4 MA Inhibitor DM6AVR4 RN Identification of an Alkylhydroquinone from Rhus succedanea as an Inhibitor of Tyrosinase and Melanogenesis. J Agric Food Chem. 2009 Mar 25;57(6):2200-5. DM6AVR4 RU https://pubmed.ncbi.nlm.nih.gov/19159217 DMGKV9D DI DMGKV9D DMGKV9D DN Hydroxocobalamin DMGKV9D MI TTCQ21Y DMGKV9D MN Methylmalonyl-CoA mutase (MMUT) DMGKV9D MT DTT DMGKV9D MA Cofactor DMGKV9D RN Vitamin B12. Nippon Rinsho. 1999 Oct;57(10):2205-10. DMGKV9D RU https://pubmed.ncbi.nlm.nih.gov/10540863 DMJAS3O DI DMJAS3O DMJAS3O DN Hydroxyamphetamine DMJAS3O MI DE4LYSA DMJAS3O MN Cytochrome P450 3A4 (CYP3A4) DMJAS3O MT DME DMJAS3O MA Metabolism DMJAS3O RN Stereoselective method development and validation for determination of concentrations of amphetamine-type stimulants and metabolites in human urine using a simultaneous extraction-chiral derivatization approach. J Chromatogr B Analyt Technol Biomed Life Sci. 2011 Jan 1;879(1):8-16. DMJAS3O RU https://www.ncbi.nlm.nih.gov/pubmed/?term=21147046 DMQSGM0 DI DMQSGM0 DMQSGM0 DN Hydroxyamphetamine Hydrobromide DMQSGM0 MI TTIU98M DMQSGM0 MN Trace amine-associated receptor-1 (TAAR1) DMQSGM0 MT DTT DMQSGM0 MA Modulator DMQSGM0 RN Diagnostic pharmacology of the pupil.Clin Neuropharmacol.1985;8(1):27-37. DMQSGM0 RU https://www.ncbi.nlm.nih.gov/pubmed/3884149 DMSIVND DI DMSIVND DMSIVND DN Hydroxychloroquine DMSIVND MI DTI7UX6 DMSIVND MN Breast cancer resistance protein (ABCG2) DMSIVND MT DTP DMSIVND MA Substrate DMSIVND RN MDR-ABC transporters: biomarkers in rheumatoid arthritis. Clin Exp Rheumatol. 2013 Sep-Oct;31(5):779-87. DMSIVND RU http://www.ncbi.nlm.nih.gov/pubmed/23711386 DMSIVND DI DMSIVND DMSIVND DN Hydroxychloroquine DMSIVND MI DE4LYSA DMSIVND MN Cytochrome P450 3A4 (CYP3A4) DMSIVND MT DME DMSIVND MA Metabolism DMSIVND RN Hydroxychloroquine: a physiologically-based pharmacokinetic model in the context of cancer-related autophagy modulation. J Pharmacol Exp Ther. 2018 Jun;365(3):447-459. DMSIVND RU https://www.ncbi.nlm.nih.gov/pubmed/?term=29438998 DMSIVND DI DMSIVND DMSIVND DN Hydroxychloroquine DMSIVND MI TTRJ1K4 DMSIVND MN Toll-like receptor 7 (TLR7) DMSIVND MT DTT DMSIVND MA Antagonist DMSIVND RN TLR7/9 antagonists as therapeutics for immune-mediated inflammatory disorders. Inflamm Allergy Drug Targets. 2007 Dec;6(4):223-35. DMSIVND RU https://pubmed.ncbi.nlm.nih.gov/18220957 DMGIZF5 DI DMGIZF5 DMGIZF5 DN Hydroxyflutamide DMGIZF5 MI TTS64P2 DMGIZF5 MN Androgen receptor (AR) DMGIZF5 MT DTT DMGIZF5 MA Antagonist DMGIZF5 RN Drug insight: role of the androgen receptor in the development and progression of prostate cancer. Nat Clin Pract Oncol. 2007 Apr;4(4):236-44. DMGIZF5 RU https://pubmed.ncbi.nlm.nih.gov/17392714 DMIKQH5 DI DMIKQH5 DMIKQH5 DN Hydroxyprogesterone DMIKQH5 MI DE4LYSA DMIKQH5 MN Cytochrome P450 3A4 (CYP3A4) DMIKQH5 MT DME DMIKQH5 MA Metabolism DMIKQH5 RN Prevention of preterm delivery with 17-hydroxyprogesterone caproate: pharmacologic considerations. Semin Perinatol. 2014 Dec;38(8):516-22. DMIKQH5 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=25256193 DMIKQH5 DI DMIKQH5 DMIKQH5 DN Hydroxyprogesterone DMIKQH5 MI DEIBDNY DMIKQH5 MN Cytochrome P450 3A5 (CYP3A5) DMIKQH5 MT DME DMIKQH5 MA Metabolism DMIKQH5 RN Prevention of preterm delivery with 17-hydroxyprogesterone caproate: pharmacologic considerations. Semin Perinatol. 2014 Dec;38(8):516-22. DMIKQH5 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=25256193 DMIKQH5 DI DMIKQH5 DMIKQH5 DN Hydroxyprogesterone DMIKQH5 MI DE0JMZ5 DMIKQH5 MN Steroid 21-hydroxylase (CYP21A2) DMIKQH5 MT DME DMIKQH5 MA Metabolism DMIKQH5 RN Functional characterization of two novel point mutations in the CYP21 gene causing simple virilizing forms of congenital adrenal hyperplasia due to 21-hydroxylase deficiency. J Clin Endocrinol Metab. 2005 Jan;90(1):445-54. DMIKQH5 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=15483094 DMIKQH5 DI DMIKQH5 DMIKQH5 DN Hydroxyprogesterone DMIKQH5 MI DEYGVN4 DMIKQH5 MN UDP-glucuronosyltransferase 1A1 (UGT1A1) DMIKQH5 MT DME DMIKQH5 MA Metabolism DMIKQH5 RN The glucuronidation of Delta4-3-Keto C19- and C21-hydroxysteroids by human liver microsomal and recombinant UDP-glucuronosyltransferases (UGTs): 6alpha- and 21-hydroxyprogesterone are selective substrates for UGT2B7. Drug Metab Dispos. 2007 Mar;35(3):363-70. DMIKQH5 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=17151189 DMR5QS6 DI DMR5QS6 DMR5QS6 DN Hydroxystilbamidine Isethionate DMR5QS6 MI TTS1W4A DMR5QS6 MN Bacterial Deoxyribonucleic acid (Bact DNA) DMR5QS6 MT DTT DMR5QS6 MA Modulator DMR5QS6 RN Interaction between hydroxystilbamidine and DNA. I. Binding isotherms and thermodynamics of the association. Biochim Biophys Acta. 1975 Sep 12;407(1):24-42. DMR5QS6 RU https://www.ncbi.nlm.nih.gov/pubmed/1242363 DMOQVU9 DI DMOQVU9 DMOQVU9 DN Hydroxyurea DMOQVU9 MI DTE2B1D DMOQVU9 MN Organic anion transporting polypeptide 1A2 (SLCO1A2) DMOQVU9 MT DTP DMOQVU9 MA Substrate DMOQVU9 RN Transcellular movement of hydroxyurea is mediated by specific solute carrier transporters. Exp Hematol. 2011 Apr;39(4):446-56. DMOQVU9 RU http://www.ncbi.nlm.nih.gov/pubmed/21256917 DMOQVU9 DI DMOQVU9 DMOQVU9 DN Hydroxyurea DMOQVU9 MI DT3D8F0 DMOQVU9 MN Organic anion transporting polypeptide 1B1 (SLCO1B1) DMOQVU9 MT DTP DMOQVU9 MA Substrate DMOQVU9 RN Transcellular movement of hydroxyurea is mediated by specific solute carrier transporters. Exp Hematol. 2011 Apr;39(4):446-56. DMOQVU9 RU http://www.ncbi.nlm.nih.gov/pubmed/21256917 DMOQVU9 DI DMOQVU9 DMOQVU9 DN Hydroxyurea DMOQVU9 MI DT9C1TS DMOQVU9 MN Organic anion transporting polypeptide 1B3 (SLCO1B3) DMOQVU9 MT DTP DMOQVU9 MA Substrate DMOQVU9 RN Transcellular movement of hydroxyurea is mediated by specific solute carrier transporters. Exp Hematol. 2011 Apr;39(4):446-56. DMOQVU9 RU http://www.ncbi.nlm.nih.gov/pubmed/21256917 DMOQVU9 DI DMOQVU9 DMOQVU9 DN Hydroxyurea DMOQVU9 MI DTUGYRD DMOQVU9 MN P-glycoprotein 1 (ABCB1) DMOQVU9 MT DTP DMOQVU9 MA Substrate DMOQVU9 RN Mammalian drug efflux transporters of the ATP binding cassette (ABC) family in multidrug resistance: A review of the past decade. Cancer Lett. 2016 Jan 1;370(1):153-64. DMOQVU9 RU http://www.ncbi.nlm.nih.gov/pubmed/26499806 DMOQVU9 DI DMOQVU9 DMOQVU9 DN Hydroxyurea DMOQVU9 MI TTBWDI0 DMOQVU9 MN Ribonucleoside-diphosphate reductase M2 (RRM2) DMOQVU9 MT DTT DMOQVU9 MA Modulator DMOQVU9 RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. DMOQVU9 RU https://www.fda.gov/ DMF8Y74 DI DMF8Y74 DMF8Y74 DN Hydroxyzine DMF8Y74 MI DE4LYSA DMF8Y74 MN Cytochrome P450 3A4 (CYP3A4) DMF8Y74 MT DME DMF8Y74 MA Metabolism DMF8Y74 RN Product characteristics of HYDROXYZINE (Hydroxyzine Hydrochloride Capsules). DMF8Y74 RU https://www.aapharma.ca/downloads/en/PIL/2018/Hydroxyzine-Pr_Info_Mono-ENG-Jul_09_2018.pdf DMF8Y74 DI DMF8Y74 DMF8Y74 DN Hydroxyzine DMF8Y74 MI DEIBDNY DMF8Y74 MN Cytochrome P450 3A5 (CYP3A5) DMF8Y74 MT DME DMF8Y74 MA Metabolism DMF8Y74 RN Product characteristics of HYDROXYZINE (Hydroxyzine Hydrochloride Capsules). DMF8Y74 RU https://www.aapharma.ca/downloads/en/PIL/2018/Hydroxyzine-Pr_Info_Mono-ENG-Jul_09_2018.pdf DMF8Y74 DI DMF8Y74 DMF8Y74 DN Hydroxyzine DMF8Y74 MI TTTIBOJ DMF8Y74 MN Histamine H1 receptor (H1R) DMF8Y74 MT DTT DMF8Y74 MA Antagonist DMF8Y74 RN Hydroxyzine, a first generation H(1)-receptor antagonist, inhibits human ether-a-go-go-related gene (HERG) current and causes syncope in a patient ... J Pharmacol Sci. 2008 Dec;108(4):462-71. DMF8Y74 RU https://pubmed.ncbi.nlm.nih.gov/19057127 DMVAIH4 DI DMVAIH4 DMVAIH4 DN Hylenex DMVAIH4 MI TTYTVXF DMVAIH4 MN Hyaluronic acid (HA) DMVAIH4 MT DTT DMVAIH4 MA Modulator DMVAIH4 RN Targeting the tumor microenvironment in cancer: why hyaluronidase deserves a second look. Cancer Discov. 2011 September; 1(4): 291-296. DMVAIH4 RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3204883/ DM804UR DI DM804UR DM804UR DN Hyoscyamine DM804UR MI TTH18TF DM804UR MN Muscarinic acetylcholine receptor M5 (CHRM5) DM804UR MT DTT DM804UR MA Antagonist DM804UR RN Reconstitution of the purified porcine atrial muscarinic acetylcholine receptor with purified porcine atrial inhibitory guanine nucleotide binding protein. Biochemistry. 1987 Dec 15;26(25):8175-82. DM804UR RU https://pubmed.ncbi.nlm.nih.gov/3126798 DM0RXF5 DI DM0RXF5 DM0RXF5 DN Hyqvia DM0RXF5 MI TTXFI1K DM0RXF5 MN Hyaluronidase (HYAL) DM0RXF5 MT DTT DM0RXF5 MA Modulator DM0RXF5 RN 2014 FDA drug approvals. Nat Rev Drug Discov. 2015 Feb;14(2):77-81. DM0RXF5 RU https://pubmed.ncbi.nlm.nih.gov/25633781 DMV67QO DI DMV67QO DMV67QO DN Ibalizumab DMV67QO MI TTN2JFW DMV67QO MN T-cell surface glycoprotein CD4 (CD4) DMV67QO MT DTT DMV67QO MA Modulator DMV67QO RN 2018 FDA drug approvals.Nat Rev Drug Discov. 2019 Feb;18(2):85-89. DMV67QO RU https://pubmed.ncbi.nlm.nih.gov/30710142 DM0QZBN DI DM0QZBN DM0QZBN DN Ibandronate DM0QZBN MI TTIKWV4 DM0QZBN MN Geranyltranstransferase (FDPS) DM0QZBN MT DTT DM0QZBN MA Modulator DM0QZBN RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. DM0QZBN RU https://www.fda.gov/ DMGUX67 DI DMGUX67 DMGUX67 DN Ibopamine hci DMGUX67 MI TTEX248 DMGUX67 MN Dopamine D2 receptor (D2R) DMGUX67 MT DTT DMGUX67 MA Modulator DMGUX67 RN Natural products as sources of new drugs over the last 25 years. J Nat Prod. 2007 Mar;70(3):461-77. DMGUX67 RU https://pubmed.ncbi.nlm.nih.gov/17309302 DMG594T DI DMG594T DMG594T DN Ibritumomab DMG594T MI TTUE541 DMG594T MN Leukocyte surface antigen Leu-16 (CD20) DMG594T MT DTT DMG594T RN Structure of the Fab fragment of therapeutic antibody Ofatumumab provides insights into the recognition mechanism with CD20. Mol Immunol. 2009 Jul;46(11-12):2419-23. DMG594T RU https://pubmed.ncbi.nlm.nih.gov/19427037 DMHZCPO DI DMHZCPO DMHZCPO DN Ibrutinib DMHZCPO MI DECB0K3 DMHZCPO MN Cytochrome P450 2D6 (CYP2D6) DMHZCPO MT DME DMHZCPO MA Metabolism DMHZCPO RN Absorption, metabolism, and excretion of oral 14C radiolabeled ibrutinib: an open-label, phase I, single-dose study in healthy men. Drug Metab Dispos. 2015 Feb;43(2):289-97. DMHZCPO RU https://www.ncbi.nlm.nih.gov/pubmed/?term=25488930 DMHZCPO DI DMHZCPO DMHZCPO DN Ibrutinib DMHZCPO MI DE4LYSA DMHZCPO MN Cytochrome P450 3A4 (CYP3A4) DMHZCPO MT DME DMHZCPO MA Metabolism DMHZCPO RN Absorption, metabolism, and excretion of oral 14C radiolabeled ibrutinib: an open-label, phase I, single-dose study in healthy men. Drug Metab Dispos. 2015 Feb;43(2):289-97. DMHZCPO RU https://www.ncbi.nlm.nih.gov/pubmed/?term=25488930 DMHZCPO DI DMHZCPO DMHZCPO DN Ibrutinib DMHZCPO MI DEIBDNY DMHZCPO MN Cytochrome P450 3A5 (CYP3A5) DMHZCPO MT DME DMHZCPO MA Metabolism DMHZCPO RN Absorption, metabolism, and excretion of oral 14C radiolabeled ibrutinib: an open-label, phase I, single-dose study in healthy men. Drug Metab Dispos. 2015 Feb;43(2):289-97. DMHZCPO RU https://www.ncbi.nlm.nih.gov/pubmed/?term=25488930 DMHZCPO DI DMHZCPO DMHZCPO DN Ibrutinib DMHZCPO MI DTUGYRD DMHZCPO MN P-glycoprotein 1 (ABCB1) DMHZCPO MT DTP DMHZCPO MA Substrate DMHZCPO RN P-Glycoprotein (MDR1/ABCB1) Restricts Brain Penetration of the Bruton's Tyrosine Kinase Inhibitor Ibrutinib, While Cytochrome P450-3A (CYP3A) Limits Its Oral Bioavailability. Mol Pharm. 2018 Nov 5;15(11):5124-5134. DMHZCPO RU http://www.ncbi.nlm.nih.gov/pubmed/30247919 DMHZCPO DI DMHZCPO DMHZCPO DN Ibrutinib DMHZCPO MI TTGM6VW DMHZCPO MN Tyrosine-protein kinase BTK (ATK) DMHZCPO MT DTT DMHZCPO MA Inhibitor DMHZCPO RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1948). DMHZCPO RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1948 DM4LSPN DI DM4LSPN DM4LSPN DN Ibudilast DM4LSPN MI TTZCG4L DM4LSPN MN Phosphodiesterase 3 (PDE3) DM4LSPN MT DTT DM4LSPN MA Inhibitor DM4LSPN RN Therapeutic targeting of 3',5'-cyclic nucleotide phosphodiesterases: inhibition and beyond. Nat Rev Drug Discov. 2019 Oct;18(10):770-796. DM4LSPN RU https://pubmed.ncbi.nlm.nih.gov/31388135 DM4LSPN DI DM4LSPN DM4LSPN DN Ibudilast DM4LSPN MI TTV5CGO DM4LSPN MN Phosphodiesterase 4 (PDE4) DM4LSPN MT DTT DM4LSPN MA Inhibitor DM4LSPN RN Therapeutic targeting of 3',5'-cyclic nucleotide phosphodiesterases: inhibition and beyond. Nat Rev Drug Discov. 2019 Oct;18(10):770-796. DM4LSPN RU https://pubmed.ncbi.nlm.nih.gov/31388135 DM8VCBE DI DM8VCBE DM8VCBE DN Ibuprofen DM8VCBE MI DEMEPVJ DM8VCBE MN Acyl-CoA thioesterase 2 (ACOT2) DM8VCBE MT DME DM8VCBE MA Metabolism DM8VCBE RN A study on the chiral inversion of mandelic acid in humans. Org Biomol Chem. 2014 Sep 14;12(34):6737-44. DM8VCBE RU https://www.ncbi.nlm.nih.gov/pubmed/?term=25050409 DM8VCBE DI DM8VCBE DM8VCBE DN Ibuprofen DM8VCBE MI DEGKWJB DM8VCBE MN Alpha-methylacyl-CoA racemase (AMACR) DM8VCBE MT DME DM8VCBE MA Metabolism DM8VCBE RN Ibuprofen: pharmacology, efficacy and safety. Inflammopharmacology. 2009 Dec;17(6):275-342. DM8VCBE RU https://www.ncbi.nlm.nih.gov/pubmed/?term=19949916 DM8VCBE DI DM8VCBE DM8VCBE DN Ibuprofen DM8VCBE MI TTMWT8Z DM8VCBE MN C-X-C chemokine receptor type 1 (CXCR1) DM8VCBE MT DTT DM8VCBE MA Inhibitor DM8VCBE RN 2-Arylpropionic CXC chemokine receptor 1 (CXCR1) ligands as novel noncompetitive CXCL8 inhibitors. J Med Chem. 2005 Jun 30;48(13):4312-31. DM8VCBE RU https://pubmed.ncbi.nlm.nih.gov/15974585 DM8VCBE DI DM8VCBE DM8VCBE DN Ibuprofen DM8VCBE MI TT30C9G DM8VCBE MN C-X-C chemokine receptor type 2 (CXCR2) DM8VCBE MT DTT DM8VCBE MA Inhibitor DM8VCBE RN 2-Arylpropionic CXC chemokine receptor 1 (CXCR1) ligands as novel noncompetitive CXCL8 inhibitors. J Med Chem. 2005 Jun 30;48(13):4312-31. DM8VCBE RU https://pubmed.ncbi.nlm.nih.gov/15974585 DM8VCBE DI DM8VCBE DM8VCBE DN Ibuprofen DM8VCBE MI DES5XRU DM8VCBE MN Cytochrome P450 2C8 (CYP2C8) DM8VCBE MT DME DM8VCBE MA Metabolism DM8VCBE RN Influence of CYP2C8 polymorphisms on the hydroxylation metabolism of paclitaxel, repaglinide and ibuprofen enantiomers in vitro. Biopharm Drug Dispos. 2013 Jul;34(5):278-87. DM8VCBE RU https://www.ncbi.nlm.nih.gov/pubmed/?term=23536207 DM8VCBE DI DM8VCBE DM8VCBE DN Ibuprofen DM8VCBE MI DE5IED8 DM8VCBE MN Cytochrome P450 2C9 (CYP2C9) DM8VCBE MT DME DM8VCBE MA Metabolism DM8VCBE RN Summary of information on human CYP enzymes: human P450 metabolism data. Drug Metab Rev. 2002 Feb-May;34(1-2):83-448. DM8VCBE RU https://www.ncbi.nlm.nih.gov/pubmed/?term=11996015 DM8VCBE DI DM8VCBE DM8VCBE DN Ibuprofen DM8VCBE MI DE4LYSA DM8VCBE MN Cytochrome P450 3A4 (CYP3A4) DM8VCBE MT DME DM8VCBE MA Metabolism DM8VCBE RN PharmGKB summary: ibuprofen pathways. Pharmacogenet Genomics. 2015 Feb;25(2):96-106. DM8VCBE RU https://www.ncbi.nlm.nih.gov/pubmed/?term=25502615 DM8VCBE DI DM8VCBE DM8VCBE DN Ibuprofen DM8VCBE MI TTCTE1G DM8VCBE MN Interleukin-8 (IL8) DM8VCBE MT DTT DM8VCBE MA Inhibitor DM8VCBE RN Structure-Activity Relationship of novel phenylacetic CXCR1 inhibitors. Bioorg Med Chem Lett. 2009 Aug 1;19(15):4026-30. DM8VCBE RU https://pubmed.ncbi.nlm.nih.gov/19560921 DM8VCBE DI DM8VCBE DM8VCBE DN Ibuprofen DM8VCBE MI DEGTFWK DM8VCBE MN Mephenytoin 4-hydroxylase (CYP2C19) DM8VCBE MT DME DM8VCBE MA Metabolism DM8VCBE RN Summary of information on human CYP enzymes: human P450 metabolism data. Drug Metab Rev. 2002 Feb-May;34(1-2):83-448. DM8VCBE RU https://www.ncbi.nlm.nih.gov/pubmed/?term=11996015 DM8VCBE DI DM8VCBE DM8VCBE DN Ibuprofen DM8VCBE MI DTLT3UG DM8VCBE MN Monocarboxylate transporter 2 (SLC16A7) DM8VCBE MT DTP DM8VCBE MA Substrate DM8VCBE RN Monocarboxylate Transporters in Drug Disposition: Role in the Toxicokinetics and Toxicodynamics of the Drug of Abuse GHB. DM8VCBE RU https://www.njacs.org/wp-content/docs/2010-Spring-DrugMet-Marilyn_Morris.pdf DM8VCBE DI DM8VCBE DM8VCBE DN Ibuprofen DM8VCBE MI DTHE530 DM8VCBE MN Probable small intestine urate exporter (SLC17A4) DM8VCBE MT DTP DM8VCBE MA Substrate DM8VCBE RN A Na+-phosphate cotransporter homologue (SLC17A4 protein) is an intestinal organic anion exporter. Am J Physiol Cell Physiol. 2012 Jun 1;302(11):C1652-60. DM8VCBE RU http://www.ncbi.nlm.nih.gov/pubmed/22460716 DM8VCBE DI DM8VCBE DM8VCBE DN Ibuprofen DM8VCBE MI TTVKILB DM8VCBE MN Prostaglandin G/H synthase 2 (COX-2) DM8VCBE MT DTT DM8VCBE MA Inhibitor DM8VCBE RN Maternal toxicity of nonsteroidal anti-inflammatory drugs as an important factor affecting prenatal development. Reprod Toxicol. 2009 Sep;28(2):239-44. DM8VCBE RU https://pubmed.ncbi.nlm.nih.gov/19379806 DM8VCBE DI DM8VCBE DM8VCBE DN Ibuprofen DM8VCBE MI DEF2WXN DM8VCBE MN UDP-glucuronosyltransferase 1A3 (UGT1A3) DM8VCBE MT DME DM8VCBE MA Metabolism DM8VCBE RN Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. DM8VCBE RU https://www.ncbi.nlm.nih.gov/pubmed/?term=19515014 DM8VCBE DI DM8VCBE DM8VCBE DN Ibuprofen DM8VCBE MI DE85D2P DM8VCBE MN UDP-glucuronosyltransferase 1A9 (UGT1A9) DM8VCBE MT DME DM8VCBE MA Metabolism DM8VCBE RN Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. DM8VCBE RU https://www.ncbi.nlm.nih.gov/pubmed/?term=19515014 DM8VCBE DI DM8VCBE DM8VCBE DN Ibuprofen DM8VCBE MI DEB3CV1 DM8VCBE MN UDP-glucuronosyltransferase 2B7 (UGT2B7) DM8VCBE MT DME DM8VCBE MA Metabolism DM8VCBE RN Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. DM8VCBE RU https://www.ncbi.nlm.nih.gov/pubmed/?term=19515014 DMFJ8LT DI DMFJ8LT DMFJ8LT DN Ibutamoren DMFJ8LT MI TTWDC17 DMFJ8LT MN Growth hormone secretagogue receptor 1 (GHSR) DMFJ8LT MT DTT DMFJ8LT MA Modulator DMFJ8LT RN Design and biological activities of L-163,191 (MK-0677): a potent, orally active growth hormone secretagogue. Proc Natl Acad Sci U S A. 1995 Jul 18;92(15):7001-5. DMFJ8LT RU https://www.ncbi.nlm.nih.gov/pubmed/7624358 DMKXY2R DI DMKXY2R DMKXY2R DN Ibutilide DMKXY2R MI TT1VOHK DMKXY2R MN Potassium channel unspecific (KC) DMKXY2R MT DTT DMKXY2R MA Modulator DMKXY2R RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. DMKXY2R RU https://www.fda.gov/ DMQPTOZ DI DMQPTOZ DMQPTOZ DN Icatibant DMQPTOZ MI TTGY8IW DMQPTOZ MN B2 bradykinin receptor (BDKRB2) DMQPTOZ MT DTT DMQPTOZ MA Antagonist DMQPTOZ RN Bradykinin receptor antagonists--a review of the patent literature 2005-2008. Expert Opin Ther Pat. 2009 Jul;19(7):919-41. DMQPTOZ RU https://pubmed.ncbi.nlm.nih.gov/19552510 DM648X9 DI DM648X9 DM648X9 DN Icodextrin DM648X9 MI DET64RG DM648X9 MN Pancreatic alpha-amylase (AMY2A) DM648X9 MT DME DM648X9 MA Metabolism DM648X9 RN Analytical interferences in point-of-care testing glucometers by icodextrin and its metabolites: an overview. Perit Dial Int. 2009 Jul-Aug;29(4):377-83. DM648X9 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=19602602 DMJHN0A DI DMJHN0A DMJHN0A DN Icosapent DMJHN0A MI TTK0943 DMJHN0A MN Prostaglandin G/H synthase (COX) DMJHN0A MT DTT DMJHN0A MA Binder DMJHN0A RN Differential modulation of Toll-like receptors by fatty acids: preferential inhibition by n-3 polyunsaturated fatty acids. J Lipid Res. 2003 Mar;44(3):479-86. DMJHN0A RU https://pubmed.ncbi.nlm.nih.gov/12562875 DMM0XGL DI DMM0XGL DMM0XGL DN Idarubicin DMM0XGL MI DTI7UX6 DMM0XGL MN Breast cancer resistance protein (ABCG2) DMM0XGL MT DTP DMM0XGL MA Substrate DMM0XGL RN Amonafide L-malate is not a substrate for multidrug resistance proteins in secondary acute myeloid leukemia. Leukemia. 2008 Nov;22(11):2110-5. DMM0XGL RU https://doi.org/10.1038/leu.2008.87 DMM0XGL DI DMM0XGL DMM0XGL DN Idarubicin DMM0XGL MI DE5IED8 DMM0XGL MN Cytochrome P450 2C9 (CYP2C9) DMM0XGL MT DME DMM0XGL MA Metabolism DMM0XGL RN In vitro evaluation of cytochrome P450-mediated drug interactions between cytarabine, idarubicin, itraconazole and caspofungin. Hematology. 2004 Jun;9(3):217-21. DMM0XGL RU https://www.ncbi.nlm.nih.gov/pubmed/?term=15204103 DMM0XGL DI DMM0XGL DMM0XGL DN Idarubicin DMM0XGL MI DECB0K3 DMM0XGL MN Cytochrome P450 2D6 (CYP2D6) DMM0XGL MT DME DMM0XGL MA Metabolism DMM0XGL RN In vitro evaluation of cytochrome P450-mediated drug interactions between cytarabine, idarubicin, itraconazole and caspofungin. Hematology. 2004 Jun;9(3):217-21. DMM0XGL RU https://www.ncbi.nlm.nih.gov/pubmed/?term=15204103 DMM0XGL DI DMM0XGL DMM0XGL DN Idarubicin DMM0XGL MI TT0IHXV DMM0XGL MN DNA topoisomerase II (TOP2) DMM0XGL MT DTT DMM0XGL MA Modulator DMM0XGL RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. DMM0XGL RU https://www.fda.gov/ DMM0XGL DI DMM0XGL DMM0XGL DN Idarubicin DMM0XGL MI DTSYQGK DMM0XGL MN Multidrug resistance-associated protein 1 (ABCC1) DMM0XGL MT DTP DMM0XGL MA Substrate DMM0XGL RN Human intestinal transporter database: QSAR modeling and virtual profiling of drug uptake, efflux and interactions. Pharm Res. 2013 Apr;30(4):996-1007. DMM0XGL RU https://doi.org/10.1007/s11095-012-0935-x DMM0XGL DI DMM0XGL DMM0XGL DN Idarubicin DMM0XGL MI DTUGYRD DMM0XGL MN P-glycoprotein 1 (ABCB1) DMM0XGL MT DTP DMM0XGL MA Substrate DMM0XGL RN Amonafide L-malate is not a substrate for multidrug resistance proteins in secondary acute myeloid leukemia. Leukemia. 2008 Nov;22(11):2110-5. DMM0XGL RU https://doi.org/10.1038/leu.2008.87 DMXEACF DI DMXEACF DMXEACF DN Idarucizumab DMXEACF MI TTFDXCO DMXEACF MN Dabigatran (Dabi) DMXEACF MT DTT DMXEACF MA Binder DMXEACF RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health Human Services. 2015 DMXEACF RU https://www.accessdata.fda.gov/drugsatfda_docs/label/2015/761025lbl.pdf DMQFDRC DI DMQFDRC DMQFDRC DN Idebenone DMQFDRC MI DEJGDUW DMQFDRC MN Cytochrome P450 1A2 (CYP1A2) DMQFDRC MT DME DMQFDRC MA Metabolism DMQFDRC RN Pharmacokinetic evaluation of idebenone. Expert Opin Drug Metab Toxicol. 2010 Nov;6(11):1437-44. DMQFDRC RU https://www.ncbi.nlm.nih.gov/pubmed/?term=20955109 DMP1QTS DI DMP1QTS DMP1QTS DN Idecabtagene vicleucel DMP1QTS MI TTZ3P4W DMP1QTS MN B-cell maturation protein (TNFRSF17) DMP1QTS MT DTT DMP1QTS MA CAR-T-Cell-Therapy DMP1QTS RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health Human Services. DMP1QTS RU https://www.fda.gov/vaccines-blood-biologics/abecma-idecabtagene-vicleucel DM602WT DI DM602WT DM602WT DN Idelalisib DM602WT MI DTI7UX6 DM602WT MN Breast cancer resistance protein (ABCG2) DM602WT MT DTP DM602WT MA Substrate DM602WT RN DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. (ID: DB09054) DM602WT RU https://www.drugbank.ca/drugs/DB09054 DM602WT DI DM602WT DM602WT DN Idelalisib DM602WT MI DE4LYSA DM602WT MN Cytochrome P450 3A4 (CYP3A4) DM602WT MT DME DM602WT MA Metabolism DM602WT RN FDA label of Idelalisib. The 2020 official website of the U.S. Food and Drug Administration. DM602WT RU https://www.accessdata.fda.gov/drugsatfda_docs/nda/2014/206545Orig1s000ClinPharmR.pdf DM602WT DI DM602WT DM602WT DN Idelalisib DM602WT MI TTGBPJE DM602WT MN PI3-kinase delta (PIK3CD) DM602WT MT DTT DM602WT MA Inhibitor DM602WT RN 2014 FDA drug approvals. Nat Rev Drug Discov. 2015 Feb;14(2):77-81. DM602WT RU https://pubmed.ncbi.nlm.nih.gov/25633781 DMDRT0E DI DMDRT0E DMDRT0E DN Idoxuridine DMDRT0E MI TT4823K DMDRT0E MN Virus Deoxyribonucleic acid (Viru DNA) DMDRT0E MT DTT DMDRT0E MA Binder DMDRT0E RN Radiopharmaceuticals (Strontium 89) and radiosensitizers (idoxuridine). J Intraven Nurs. 1998 Nov-Dec;21(6):335-7. DMDRT0E RU https://pubmed.ncbi.nlm.nih.gov/10392098 DM30SXV DI DM30SXV DM30SXV DN Idursulfase DM30SXV MI TTNY2AP DM30SXV MN Iduronate 2-sulfatase (IDS) DM30SXV MT DTT DM30SXV MA Modulator DM30SXV RN 2006 drug approvals: finding the niche. Nat Rev Drug Discov. 2007 Feb;6(2):99-101. DM30SXV RU https://pubmed.ncbi.nlm.nih.gov/17342860 DMCT3I8 DI DMCT3I8 DMCT3I8 DN Ifosfamide DMCT3I8 MI DEJVYAZ DMCT3I8 MN Cytochrome P450 2A6 (CYP2A6) DMCT3I8 MT DME DMCT3I8 MA Metabolism DMCT3I8 RN Measurement of 4-hydroxylation of ifosfamide in human liver microsomes using the estimation of free and protein-bound acrolein and codetermination of keto- and carboxyifosfamide. J Cancer Res Clin Oncol. 2002 Jul;128(7):385-92. DMCT3I8 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=12136253 DMCT3I8 DI DMCT3I8 DMCT3I8 DN Ifosfamide DMCT3I8 MI DEPKLMQ DMCT3I8 MN Cytochrome P450 2B6 (CYP2B6) DMCT3I8 MT DME DMCT3I8 MA Metabolism DMCT3I8 RN A novel distal enhancer module regulated by pregnane X receptor/constitutive androstane receptor is essential for the maximal induction of CYP2B6 gene expression. J Biol Chem. 2003 Apr 18;278(16):14146-52. DMCT3I8 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=12571232 DMCT3I8 DI DMCT3I8 DMCT3I8 DN Ifosfamide DMCT3I8 MI DEZMWRE DMCT3I8 MN Cytochrome P450 2C18 (CYP2C18) DMCT3I8 MT DME DMCT3I8 MA Metabolism DMCT3I8 RN Development of a substrate-activity based approach to identify the major human liver P-450 catalysts of cyclophosphamide and ifosfamide activation based on cDNA-expressed activities and liver microsomal P-450 profiles. Drug Metab Dispos. 1999 Jun;27(6):655-66. DMCT3I8 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=10348794 DMCT3I8 DI DMCT3I8 DMCT3I8 DN Ifosfamide DMCT3I8 MI DES5XRU DMCT3I8 MN Cytochrome P450 2C8 (CYP2C8) DMCT3I8 MT DME DMCT3I8 MA Metabolism DMCT3I8 RN Enhanced cyclophosphamide and ifosfamide activation in primary human hepatocyte cultures: response to cytochrome P-450 inducers and autoinduction by oxazaphosphorines. Cancer Res. 1997 May 15;57(10):1946-54. DMCT3I8 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=9157990 DMCT3I8 DI DMCT3I8 DMCT3I8 DN Ifosfamide DMCT3I8 MI DE5IED8 DMCT3I8 MN Cytochrome P450 2C9 (CYP2C9) DMCT3I8 MT DME DMCT3I8 MA Metabolism DMCT3I8 RN CYP2C9 polymorphisms in human tumors. Anticancer Res. 2006 Jan-Feb;26(1A):299-305. DMCT3I8 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=16475710 DMCT3I8 DI DMCT3I8 DMCT3I8 DN Ifosfamide DMCT3I8 MI DE4LYSA DMCT3I8 MN Cytochrome P450 3A4 (CYP3A4) DMCT3I8 MT DME DMCT3I8 MA Metabolism DMCT3I8 RN Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. DMCT3I8 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=19515014 DMCT3I8 DI DMCT3I8 DMCT3I8 DN Ifosfamide DMCT3I8 MI DEIBDNY DMCT3I8 MN Cytochrome P450 3A5 (CYP3A5) DMCT3I8 MT DME DMCT3I8 MA Metabolism DMCT3I8 RN Enhanced cyclophosphamide and ifosfamide activation in primary human hepatocyte cultures: response to cytochrome P-450 inducers and autoinduction by oxazaphosphorines. Cancer Res. 1997 May 15;57(10):1946-54. DMCT3I8 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=9157990 DMCT3I8 DI DMCT3I8 DMCT3I8 DN Ifosfamide DMCT3I8 MI DERD86B DMCT3I8 MN Cytochrome P450 3A7 (CYP3A7) DMCT3I8 MT DME DMCT3I8 MA Metabolism DMCT3I8 RN Summary of information on human CYP enzymes: human P450 metabolism data. Drug Metab Rev. 2002 Feb-May;34(1-2):83-448. DMCT3I8 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=11996015 DMCT3I8 DI DMCT3I8 DMCT3I8 DN Ifosfamide DMCT3I8 MI TTUTN1I DMCT3I8 MN Human Deoxyribonucleic acid (hDNA) DMCT3I8 MT DTT DMCT3I8 MA Modulator DMCT3I8 RN Pharmacokinetics and metabolism of ifosfamide in relation to DNA damage assessed by the COMET assay in children with cancer. Br J Cancer. 2005 May 9;92(9):1626-35. DMCT3I8 RU https://www.ncbi.nlm.nih.gov/pubmed/15827549 DMCT3I8 DI DMCT3I8 DMCT3I8 DN Ifosfamide DMCT3I8 MI DEGTFWK DMCT3I8 MN Mephenytoin 4-hydroxylase (CYP2C19) DMCT3I8 MT DME DMCT3I8 MA Metabolism DMCT3I8 RN Development of a substrate-activity based approach to identify the major human liver P-450 catalysts of cyclophosphamide and ifosfamide activation based on cDNA-expressed activities and liver microsomal P-450 profiles. Drug Metab Dispos. 1999 Jun;27(6):655-66. DMCT3I8 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=10348794 DMCT3I8 DI DMCT3I8 DMCT3I8 DN Ifosfamide DMCT3I8 MI DE073H6 DMCT3I8 MN Prostaglandin G/H synthase 1 (COX-1) DMCT3I8 MT DME DMCT3I8 MA Metabolism DMCT3I8 RN Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. DMCT3I8 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=19515014 DM6AUFY DI DM6AUFY DM6AUFY DN Iloperidone DM6AUFY MI TTJQOD7 DM6AUFY MN 5-HT 2A receptor (HTR2A) DM6AUFY MT DTT DM6AUFY MA Antagonist DM6AUFY RN Hughes B: 2009 FDA drug approvals. Nat Rev Drug Discov. 2010 Feb;9(2):89-92. DM6AUFY RU https://pubmed.ncbi.nlm.nih.gov/20118952 DM6AUFY DI DM6AUFY DM6AUFY DN Iloperidone DM6AUFY MI DECB0K3 DM6AUFY MN Cytochrome P450 2D6 (CYP2D6) DM6AUFY MT DME DM6AUFY MA Metabolism DM6AUFY RN Influences of CYP2D6*10 polymorphisms on the pharmacokinetics of iloperidone and its metabolites in Chinese patients with schizophrenia: a population pharmacokinetic analysis. Acta Pharmacol Sin. 2016 Nov;37(11):1499-1508. DM6AUFY RU https://www.ncbi.nlm.nih.gov/pubmed/?term=27665849 DM6AUFY DI DM6AUFY DM6AUFY DN Iloperidone DM6AUFY MI DE4LYSA DM6AUFY MN Cytochrome P450 3A4 (CYP3A4) DM6AUFY MT DME DM6AUFY MA Metabolism DM6AUFY RN Influences of CYP2D6*10 polymorphisms on the pharmacokinetics of iloperidone and its metabolites in Chinese patients with schizophrenia: a population pharmacokinetic analysis. Acta Pharmacol Sin. 2016 Nov;37(11):1499-1508. DM6AUFY RU https://www.ncbi.nlm.nih.gov/pubmed/?term=27665849 DM6AUFY DI DM6AUFY DM6AUFY DN Iloperidone DM6AUFY MI DEIBDNY DM6AUFY MN Cytochrome P450 3A5 (CYP3A5) DM6AUFY MT DME DM6AUFY MA Metabolism DM6AUFY RN Application of liquid chromatography/mass spectrometry in accelerating the identification of human liver cytochrome P450 isoforms involved in the metabolism of iloperidone. J Pharmacol Exp Ther. 1998 Sep;286(3):1285-93. DM6AUFY RU https://www.ncbi.nlm.nih.gov/pubmed/?term=9732390 DM6AUFY DI DM6AUFY DM6AUFY DN Iloperidone DM6AUFY MI DERD86B DM6AUFY MN Cytochrome P450 3A7 (CYP3A7) DM6AUFY MT DME DM6AUFY MA Metabolism DM6AUFY RN Application of liquid chromatography/mass spectrometry in accelerating the identification of human liver cytochrome P450 isoforms involved in the metabolism of iloperidone. J Pharmacol Exp Ther. 1998 Sep;286(3):1285-93. DM6AUFY RU https://www.ncbi.nlm.nih.gov/pubmed/?term=9732390 DM6AUFY DI DM6AUFY DM6AUFY DN Iloperidone DM6AUFY MI TTEX248 DM6AUFY MN Dopamine D2 receptor (D2R) DM6AUFY MT DTT DM6AUFY MA Antagonist DM6AUFY RN Hughes B: 2009 FDA drug approvals. Nat Rev Drug Discov. 2010 Feb;9(2):89-92. DM6AUFY RU https://pubmed.ncbi.nlm.nih.gov/20118952 DMVPZBE DI DMVPZBE DMVPZBE DN Iloprost DMVPZBE MI DT021JD DMVPZBE MN Organic anion transporting polypeptide 2A1 (SLCO2A1) DMVPZBE MT DTP DMVPZBE MA Substrate DMVPZBE RN Cloning, in vitro expression, and tissue distribution of a human prostaglandin transporter cDNA(hPGT). J Clin Invest. 1996 Sep 1;98(5):1142-9. DMVPZBE RU http://www.ncbi.nlm.nih.gov/pubmed/8787677 DMVPZBE DI DMVPZBE DMVPZBE DN Iloprost DMVPZBE MI DTVNRXW DMVPZBE MN Organic anion transporting polypeptide 3A1 (SLCO3A1) DMVPZBE MT DTP DMVPZBE MA Substrate DMVPZBE RN Molecular characterization of human and rat organic anion transporter OATP-D. Am J Physiol Renal Physiol. 2003 Dec;285(6):F1188-97. DMVPZBE RU http://www.ncbi.nlm.nih.gov/pubmed/14631946 DMVPZBE DI DMVPZBE DMVPZBE DN Iloprost DMVPZBE MI TT1ZAVI DMVPZBE MN Prostaglandin E2 receptor EP2 (PTGER2) DMVPZBE MT DTT DMVPZBE MA Agonist DMVPZBE RN Exploration of prostanoid receptor subtype regulating estradiol and prostaglandin E2 induction of spinophilin in developing preoptic area neurons. Neuroscience. 2007 May 25;146(3):1117-27. DMVPZBE RU https://pubmed.ncbi.nlm.nih.gov/17408863 DM7RJXL DI DM7RJXL DM7RJXL DN Imatinib DM7RJXL MI DTI7UX6 DM7RJXL MN Breast cancer resistance protein (ABCG2) DM7RJXL MT DTP DM7RJXL MA Substrate DM7RJXL RN Imatinib mesylate (STI571) is a substrate for the breast cancer resistance protein (BCRP)/ABCG2 drug pump. Blood. 2004 Nov 1;104(9):2940-2. DM7RJXL RU http://www.ncbi.nlm.nih.gov/pubmed/15251980 DM7RJXL DI DM7RJXL DM7RJXL DN Imatinib DM7RJXL MI DEJGDUW DM7RJXL MN Cytochrome P450 1A2 (CYP1A2) DM7RJXL MT DME DM7RJXL MA Metabolism DM7RJXL RN The effect of apigenin on pharmacokinetics of imatinib and its metabolite N-desmethyl imatinib in rats. Biomed Res Int. 2013;2013:789184. DM7RJXL RU https://www.ncbi.nlm.nih.gov/pubmed/?term=24369535 DM7RJXL DI DM7RJXL DM7RJXL DN Imatinib DM7RJXL MI DES5XRU DM7RJXL MN Cytochrome P450 2C8 (CYP2C8) DM7RJXL MT DME DM7RJXL MA Metabolism DM7RJXL RN Role of cytochrome P450 2C8 in drug metabolism and interactions. Pharmacol Rev. 2016 Jan;68(1):168-241. DM7RJXL RU https://www.ncbi.nlm.nih.gov/pubmed/?term=26721703 DM7RJXL DI DM7RJXL DM7RJXL DN Imatinib DM7RJXL MI DE5IED8 DM7RJXL MN Cytochrome P450 2C9 (CYP2C9) DM7RJXL MT DME DM7RJXL MA Metabolism DM7RJXL RN Drug-drug interactions with imatinib: an observational study. Medicine (Baltimore). 2016 Oct;95(40):e5076. DM7RJXL RU https://www.ncbi.nlm.nih.gov/pubmed/?term=27749579 DM7RJXL DI DM7RJXL DM7RJXL DN Imatinib DM7RJXL MI DECB0K3 DM7RJXL MN Cytochrome P450 2D6 (CYP2D6) DM7RJXL MT DME DM7RJXL MA Metabolism DM7RJXL RN Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. DM7RJXL RU https://www.ncbi.nlm.nih.gov/pubmed/?term=19515014 DM7RJXL DI DM7RJXL DM7RJXL DN Imatinib DM7RJXL MI DE4LYSA DM7RJXL MN Cytochrome P450 3A4 (CYP3A4) DM7RJXL MT DME DM7RJXL MA Metabolism DM7RJXL RN Potent mechanism-based inhibition of CYP3A4 by imatinib explains its liability to interact with CYP3A4 substrates. Br J Pharmacol. 2012 Apr;165(8):2787-98. DM7RJXL RU https://www.ncbi.nlm.nih.gov/pubmed/?term=22014153 DM7RJXL DI DM7RJXL DM7RJXL DN Imatinib DM7RJXL MI DEIBDNY DM7RJXL MN Cytochrome P450 3A5 (CYP3A5) DM7RJXL MT DME DM7RJXL MA Metabolism DM7RJXL RN Clinical pharmacokinetics of imatinib. Clin Pharmacokinet. 2005;44(9):879-94. DM7RJXL RU https://www.ncbi.nlm.nih.gov/pubmed/?term=16122278 DM7RJXL DI DM7RJXL DM7RJXL DN Imatinib DM7RJXL MI DERD86B DM7RJXL MN Cytochrome P450 3A7 (CYP3A7) DM7RJXL MT DME DM7RJXL MA Metabolism DM7RJXL RN Drug Interactions Flockhart Table DM7RJXL RU https://drug-interactions.medicine.iu.edu/Main-Table.aspx DM7RJXL DI DM7RJXL DM7RJXL DN Imatinib DM7RJXL MI TTS7G69 DM7RJXL MN Fusion protein Bcr-Abl (Bcr-Abl) DM7RJXL MT DTT DM7RJXL MA Inhibitor DM7RJXL RN A comparison of physicochemical property profiles of marketed oral drugs and orally bioavailable anti-cancer protein kinase inhibitors in clinical development. Curr Top Med Chem. 2007;7(14):1408-22. DM7RJXL RU https://pubmed.ncbi.nlm.nih.gov/17692029 DM7RJXL DI DM7RJXL DM7RJXL DN Imatinib DM7RJXL MI TTN6ORK DM7RJXL MN Mcl-1 messenger RNA (MCL-1 mRNA) DM7RJXL MT DTT DM7RJXL RN Design and development of antisense drugs. Expert Opin. Drug Discov. 2008 3(10):1189-1207. DM7RJXL RU http://www.informahealthcare.com/doi/abs/10.1517/17460441.3.10.1177 DM7RJXL DI DM7RJXL DM7RJXL DN Imatinib DM7RJXL MI DTE2B1D DM7RJXL MN Organic anion transporting polypeptide 1A2 (SLCO1A2) DM7RJXL MT DTP DM7RJXL MA Substrate DM7RJXL RN Environmental and genetic factors affecting transport of imatinib by OATP1A2. Clin Pharmacol Ther. 2011 Jun;89(6):816-20. DM7RJXL RU http://www.ncbi.nlm.nih.gov/pubmed/21508937 DM7RJXL DI DM7RJXL DM7RJXL DN Imatinib DM7RJXL MI DT3D8F0 DM7RJXL MN Organic anion transporting polypeptide 1B1 (SLCO1B1) DM7RJXL MT DTP DM7RJXL MA Substrate DM7RJXL RN Contribution of OATP1B1 and OATP1B3 to the disposition of sorafenib and sorafenib-glucuronide. Clin Cancer Res. 2013 Mar 15;19(6):1458-66. DM7RJXL RU http://www.ncbi.nlm.nih.gov/pubmed/23340295 DM7RJXL DI DM7RJXL DM7RJXL DN Imatinib DM7RJXL MI DT9C1TS DM7RJXL MN Organic anion transporting polypeptide 1B3 (SLCO1B3) DM7RJXL MT DTP DM7RJXL MA Substrate DM7RJXL RN Contribution of OATP1B1 and OATP1B3 to the disposition of sorafenib and sorafenib-glucuronide. Clin Cancer Res. 2013 Mar 15;19(6):1458-66. DM7RJXL RU http://www.ncbi.nlm.nih.gov/pubmed/23340295 DM7RJXL DI DM7RJXL DM7RJXL DN Imatinib DM7RJXL MI DTT79CX DM7RJXL MN Organic cation transporter 1 (SLC22A1) DM7RJXL MT DTP DM7RJXL MA Substrate DM7RJXL RN Pharmacologic markers and predictors of responses to imatinib therapy in patients with chronic myeloid leukemia. Leuk Lymphoma. 2008 Apr;49(4):639-42. DM7RJXL RU http://www.ncbi.nlm.nih.gov/pubmed/18398725 DM7RJXL DI DM7RJXL DM7RJXL DN Imatinib DM7RJXL MI DTUGYRD DM7RJXL MN P-glycoprotein 1 (ABCB1) DM7RJXL MT DTP DM7RJXL MA Substrate DM7RJXL RN Association of genetic polymorphisms in the influx transporter SLCO1B3 and the efflux transporter ABCB1 with imatinib pharmacokinetics in patients with chronic myeloid leukemia. Ther Drug Monit. 2011 Apr;33(2):244-50. DM7RJXL RU http://www.ncbi.nlm.nih.gov/pubmed/21311410 DM7RJXL DI DM7RJXL DM7RJXL DN Imatinib DM7RJXL MI TTI2WET DM7RJXL MN Platelet-derived growth factor receptor (PDGFR) DM7RJXL MT DTT DM7RJXL MA Inhibitor DM7RJXL RN A comparison of physicochemical property profiles of marketed oral drugs and orally bioavailable anti-cancer protein kinase inhibitors in clinical development. Curr Top Med Chem. 2007;7(14):1408-22. DM7RJXL RU https://pubmed.ncbi.nlm.nih.gov/17692029 DM7RJXL DI DM7RJXL DM7RJXL DN Imatinib DM7RJXL MI DE073H6 DM7RJXL MN Prostaglandin G/H synthase 1 (COX-1) DM7RJXL MT DME DM7RJXL MA Metabolism DM7RJXL RN Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. DM7RJXL RU https://www.ncbi.nlm.nih.gov/pubmed/?term=19515014 DM7RJXL DI DM7RJXL DM7RJXL DN Imatinib DM7RJXL MI TTX41N9 DM7RJXL MN Tyrosine-protein kinase Kit (KIT) DM7RJXL MT DTT DM7RJXL MA Inhibitor DM7RJXL RN A comparison of physicochemical property profiles of marketed oral drugs and orally bioavailable anti-cancer protein kinase inhibitors in clinical development. Curr Top Med Chem. 2007;7(14):1408-22. DM7RJXL RU https://pubmed.ncbi.nlm.nih.gov/17692029 DMUL7T1 DI DMUL7T1 DMUL7T1 DN Imidapril DMUL7T1 MI TTL69WB DMUL7T1 MN Angiotensin-converting enzyme (ACE) DMUL7T1 MT DTT DMUL7T1 MA Modulator DMUL7T1 RN Natural products as sources of new drugs over the last 25 years. J Nat Prod. 2007 Mar;70(3):461-77. DMUL7T1 RU https://pubmed.ncbi.nlm.nih.gov/17309302 DM3VS7Z DI DM3VS7Z DM3VS7Z DN Imidazole salicylate DM3VS7Z MI TTTEJMY DM3VS7Z MN Tromboxane A2 synthesis (TA2 synth) DM3VS7Z MT DTT DM3VS7Z MA Modulator DM3VS7Z RN Tolerability of imidazole salycilate in aspirin-sensitive patients. Allergy Proc. 1995 Sep-Oct;16(5):251-4. DM3VS7Z RU https://pubmed.ncbi.nlm.nih.gov/8566739 DMI9FBP DI DMI9FBP DMI9FBP DN Imipenem DMI9FBP MI DERI7LO DMI9FBP MN AmpC beta-lactamase (ampC) DMI9FBP MT DME DMI9FBP MA Metabolism DMI9FBP RN Characterization of the AmpC beta-Lactamase from Burkholderia multivorans. Antimicrob Agents Chemother. 2018 Sep 24;62(10). pii: e01140-18. DMI9FBP RU https://pubmed.ncbi.nlm.nih.gov/30012762 DMI9FBP DI DMI9FBP DMI9FBP DN Imipenem DMI9FBP MI TTHWB7G DMI9FBP MN Bacterial Penicillin binding protein 2 (Bact mrdA) DMI9FBP MT DTT DMI9FBP MA Binder DMI9FBP RN A comparative trial of imipenem versus ceftazidime in the release of endotoxin and cytokine generation in patients with gram-negative urosepsis. Urosepsis Study Group. J Endotoxin Res. 2000;6(1):25-31. DMI9FBP RU https://pubmed.ncbi.nlm.nih.gov/11061029 DMI9FBP DI DMI9FBP DMI9FBP DN Imipenem DMI9FBP MI DEC3G7M DMI9FBP MN Beta-lactamase (blaB) DMI9FBP MT DME DMI9FBP MA Metabolism DMI9FBP RN FRI-4 carbapenemase-producing Enterobacter cloacae complex isolated in Tokyo, Japan. J Antimicrob Chemother. 2018 Nov 1;73(11):2969-2972. DMI9FBP RU https://pubmed.ncbi.nlm.nih.gov/30060114 DMI9FBP DI DMI9FBP DMI9FBP DN Imipenem DMI9FBP MI DE7IH52 DMI9FBP MN Beta-lactamase (blaB) DMI9FBP MT DME DMI9FBP MA Metabolism DMI9FBP RN Antibiotic therapy for inducible AmpC beta-lactamase-producing Gram-negative bacilli: what are the alternatives to carbapenems, quinolones and aminoglycosides? Int J Antimicrob Agents. 2012 Oct;40(4):297-305. DMI9FBP RU https://pubmed.ncbi.nlm.nih.gov/22824371 DMI9FBP DI DMI9FBP DMI9FBP DN Imipenem DMI9FBP MI DEYIEO5 DMI9FBP MN Beta-lactamase (blaB) DMI9FBP MT DME DMI9FBP MA Metabolism DMI9FBP RN Antibiotic therapy for inducible AmpC beta-lactamase-producing Gram-negative bacilli: what are the alternatives to carbapenems, quinolones and aminoglycosides? Int J Antimicrob Agents. 2012 Oct;40(4):297-305. DMI9FBP RU https://pubmed.ncbi.nlm.nih.gov/22824371 DMI9FBP DI DMI9FBP DMI9FBP DN Imipenem DMI9FBP MI DEBKS91 DMI9FBP MN Beta-lactamase (blaB) DMI9FBP MT DME DMI9FBP MA Metabolism DMI9FBP RN A high mortality rate associated with multidrug-resistant Acinetobacter baumannii ST79 and ST25 carrying OXA-23 in a Brazilian intensive care unit. PLoS One. 2018 Dec 28;13(12):e0209367. DMI9FBP RU https://pubmed.ncbi.nlm.nih.gov/30592758 DMI9FBP DI DMI9FBP DMI9FBP DN Imipenem DMI9FBP MI DEUHIQS DMI9FBP MN Beta-lactamase (blaB) DMI9FBP MT DME DMI9FBP MA Metabolism DMI9FBP RN AmpC beta-lactamase-producing Enterobacterales: what a clinician should know. Infection. 2019 Jun;47(3):363-375. DMI9FBP RU https://pubmed.ncbi.nlm.nih.gov/30840201 DMI9FBP DI DMI9FBP DMI9FBP DN Imipenem DMI9FBP MI DECWSA9 DMI9FBP MN Beta-lactamase (blaB) DMI9FBP MT DME DMI9FBP MA Metabolism DMI9FBP RN Molecular investigation of extended-spectrum beta-lactamase genes and potential drug resistance in clinical isolates of Morganella morganii. Ann Saudi Med. 2016 May-Jun;36(3):223-8. DMI9FBP RU https://pubmed.ncbi.nlm.nih.gov/27236395 DMI9FBP DI DMI9FBP DMI9FBP DN Imipenem DMI9FBP MI DECB2MX DMI9FBP MN Beta-lactamase (blaB) DMI9FBP MT DME DMI9FBP MA Metabolism DMI9FBP RN Whole-genome sequence of Chryseobacterium oranimense, a colistin-resistant bacterium isolated from a cystic fibrosis patient in France. Antimicrob Agents Chemother. 2015 Mar;59(3):1696-706. DMI9FBP RU https://pubmed.ncbi.nlm.nih.gov/25583710 DMI9FBP DI DMI9FBP DMI9FBP DN Imipenem DMI9FBP MI DEEQ3RW DMI9FBP MN Beta-lactamase (blaB) DMI9FBP MT DME DMI9FBP MA Metabolism DMI9FBP RN Hospital sewage water: a reservoir for variants of New Delhi metallo-beta-lactamase (NDM)- and extended-spectrum beta-lactamase (ESBL)-producing Enterobacteriaceae. Int J Antimicrob Agents. 2018 Jan;51(1):82-88. DMI9FBP RU https://pubmed.ncbi.nlm.nih.gov/28887202 DMI9FBP DI DMI9FBP DMI9FBP DN Imipenem DMI9FBP MI DEQ0K5J DMI9FBP MN Beta-lactamase (blaB) DMI9FBP MT DME DMI9FBP MA Metabolism DMI9FBP RN Hospital sewage water: a reservoir for variants of New Delhi metallo-beta-lactamase (NDM)- and extended-spectrum beta-lactamase (ESBL)-producing Enterobacteriaceae. Int J Antimicrob Agents. 2018 Jan;51(1):82-88. DMI9FBP RU https://pubmed.ncbi.nlm.nih.gov/28887202 DMI9FBP DI DMI9FBP DMI9FBP DN Imipenem DMI9FBP MI DE7MYGB DMI9FBP MN Beta-lactamase (blaB) DMI9FBP MT DME DMI9FBP MA Metabolism DMI9FBP RN Antibiotic therapy for inducible AmpC beta-lactamase-producing Gram-negative bacilli: what are the alternatives to carbapenems, quinolones and aminoglycosides? Int J Antimicrob Agents. 2012 Oct;40(4):297-305. DMI9FBP RU https://pubmed.ncbi.nlm.nih.gov/22824371 DMI9FBP DI DMI9FBP DMI9FBP DN Imipenem DMI9FBP MI DEL6894 DMI9FBP MN Beta-lactamase (blaB) DMI9FBP MT DME DMI9FBP MA Metabolism DMI9FBP RN Hospital sewage water: a reservoir for variants of New Delhi metallo-beta-lactamase (NDM)- and extended-spectrum beta-lactamase (ESBL)-producing Enterobacteriaceae. Int J Antimicrob Agents. 2018 Jan;51(1):82-88. DMI9FBP RU https://pubmed.ncbi.nlm.nih.gov/28887202 DMI9FBP DI DMI9FBP DMI9FBP DN Imipenem DMI9FBP MI DE8KH4C DMI9FBP MN Beta-lactamase (blaB) DMI9FBP MT DME DMI9FBP MA Metabolism DMI9FBP RN Carbapenemase VCC-1-producing Vibrio cholerae in coastal waters of Germany. Emerg Infect Dis. 2017 Oct;23(10):1735-1737. DMI9FBP RU https://pubmed.ncbi.nlm.nih.gov/28930017 DMI9FBP DI DMI9FBP DMI9FBP DN Imipenem DMI9FBP MI DEB90AL DMI9FBP MN Carbapenemase (cphA) DMI9FBP MT DME DMI9FBP MA Metabolism DMI9FBP RN A carbapenem-resistant clinical isolate of Aeromonas hydrophila in Japan harbouring an acquired gene encoding GES-24 beta-lactamase. J Med Microbiol. 2018 Nov;67(11):1535-1537. DMI9FBP RU https://pubmed.ncbi.nlm.nih.gov/30289383 DMI9FBP DI DMI9FBP DMI9FBP DN Imipenem DMI9FBP MI DETRKSD DMI9FBP MN Carbapenemase (cphA) DMI9FBP MT DME DMI9FBP MA Metabolism DMI9FBP RN Proteomic identification of Axc, a novel beta-lactamase with carbapenemase activity in a meropenem-resistant clinical isolate of Achromobacter xylosoxidans. Sci Rep. 2018 May 25;8(1):8181. DMI9FBP RU https://pubmed.ncbi.nlm.nih.gov/29802257 DMI9FBP DI DMI9FBP DMI9FBP DN Imipenem DMI9FBP MI DEQ4LIN DMI9FBP MN Carbapenemase (cphA) DMI9FBP MT DME DMI9FBP MA Metabolism DMI9FBP RN Occurrence of a new metallo-beta-lactamase IMP-4 carried on a conjugative plasmid in Citrobacter youngae from the People's Republic of China. FEMS Microbiol Lett. 2001 Jan 1;194(1):53-7. DMI9FBP RU https://pubmed.ncbi.nlm.nih.gov/11150665 DMI9FBP DI DMI9FBP DMI9FBP DN Imipenem DMI9FBP MI DE9QNXV DMI9FBP MN Carbapenemase (cphA) DMI9FBP MT DME DMI9FBP MA Metabolism DMI9FBP RN Pseudocitrobacter gen. nov., a novel genus of the Enterobacteriaceae with two new species Pseudocitrobacter faecalis sp. nov., and Pseudocitrobacter anthropi sp. nov, isolated from fecal samples from hospitalized patients in Pakistan. Syst Appl Microbiol. 2014 Feb;37(1):17-22. DMI9FBP RU https://pubmed.ncbi.nlm.nih.gov/24182752 DM2NUH3 DI DM2NUH3 DM2NUH3 DN Imipramine DM2NUH3 MI DEJGDUW DM2NUH3 MN Cytochrome P450 1A2 (CYP1A2) DM2NUH3 MT DME DM2NUH3 MA Metabolism DM2NUH3 RN Reappraisal of human CYP isoforms involved in imipramine N-demethylation and 2-hydroxylation: a study using microsomes obtained from putative extensive and poor metabolizers of S-mephenytoin and eleven recombinant human CYPs. J Pharmacol Exp Ther. 1997 Jun;281(3):1199-210. DM2NUH3 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=9190854 DM2NUH3 DI DM2NUH3 DM2NUH3 DN Imipramine DM2NUH3 MI DEPKLMQ DM2NUH3 MN Cytochrome P450 2B6 (CYP2B6) DM2NUH3 MT DME DM2NUH3 MA Metabolism DM2NUH3 RN Reappraisal of human CYP isoforms involved in imipramine N-demethylation and 2-hydroxylation: a study using microsomes obtained from putative extensive and poor metabolizers of S-mephenytoin and eleven recombinant human CYPs. J Pharmacol Exp Ther. 1997 Jun;281(3):1199-210. DM2NUH3 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=9190854 DM2NUH3 DI DM2NUH3 DM2NUH3 DN Imipramine DM2NUH3 MI DEZMWRE DM2NUH3 MN Cytochrome P450 2C18 (CYP2C18) DM2NUH3 MT DME DM2NUH3 MA Metabolism DM2NUH3 RN Reappraisal of human CYP isoforms involved in imipramine N-demethylation and 2-hydroxylation: a study using microsomes obtained from putative extensive and poor metabolizers of S-mephenytoin and eleven recombinant human CYPs. J Pharmacol Exp Ther. 1997 Jun;281(3):1199-210. DM2NUH3 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=9190854 DM2NUH3 DI DM2NUH3 DM2NUH3 DN Imipramine DM2NUH3 MI DECB0K3 DM2NUH3 MN Cytochrome P450 2D6 (CYP2D6) DM2NUH3 MT DME DM2NUH3 MA Metabolism DM2NUH3 RN QTc prolongation associated with combination therapy of levofloxacin, imipramine, and fluoxetine. Ann Pharmacother. 2005 Mar;39(3):543-6. DM2NUH3 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=15687478 DM2NUH3 DI DM2NUH3 DM2NUH3 DN Imipramine DM2NUH3 MI DE4LYSA DM2NUH3 MN Cytochrome P450 3A4 (CYP3A4) DM2NUH3 MT DME DM2NUH3 MA Metabolism DM2NUH3 RN Variability in metabolism of imipramine and desipramine using urinary excretion data. J Anal Toxicol. 2014 Jul-Aug;38(6):368-74. DM2NUH3 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=24782142 DM2NUH3 DI DM2NUH3 DM2NUH3 DN Imipramine DM2NUH3 MI DERD86B DM2NUH3 MN Cytochrome P450 3A7 (CYP3A7) DM2NUH3 MT DME DM2NUH3 MA Metabolism DM2NUH3 RN Catalysis of drug oxidation during embryogenesis in human hepatic tissues using imipramine as a model substrate. Drug Metab Dispos. 1999 Nov;27(11):1306-8. DM2NUH3 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=10534316 DM2NUH3 DI DM2NUH3 DM2NUH3 DN Imipramine DM2NUH3 MI DEIZLTN DM2NUH3 MN Docosahexaenoic acid omega-hydroxylase (CYP4F11) DM2NUH3 MT DME DM2NUH3 MA Metabolism DM2NUH3 RN Expression and characterization of human cytochrome P450 4F11: putative role in the metabolism of therapeutic drugs and eicosanoids. Toxicol Appl Pharmacol. 2004 Sep 15;199(3):295-304. 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DM2NUH3 RU https://pubmed.ncbi.nlm.nih.gov/19059298 DM2NUH3 DI DM2NUH3 DM2NUH3 DN Imipramine DM2NUH3 MI DTUGYRD DM2NUH3 MN P-glycoprotein 1 (ABCB1) DM2NUH3 MT DTP DM2NUH3 MA Substrate DM2NUH3 RN Caco-2 permeability, P-glycoprotein transport ratios and brain penetration of heterocyclic drugs. Int J Pharm. 2003 Sep 16;263(1-2):113-22. DM2NUH3 RU http://www.ncbi.nlm.nih.gov/pubmed/12954186 DM2NUH3 DI DM2NUH3 DM2NUH3 DN Imipramine DM2NUH3 MI DEYGVN4 DM2NUH3 MN UDP-glucuronosyltransferase 1A1 (UGT1A1) DM2NUH3 MT DME DM2NUH3 MA Metabolism DM2NUH3 RN Liquid chromatography-tandem mass spectrometry method for measurement of nicotine N-glucuronide: a marker for human UGT2B10 inhibition. J Pharm Biomed Anal. 2011 Jul 15;55(5):964-71. DM2NUH3 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=21497036 DM1TMA3 DI DM1TMA3 DM1TMA3 DN Imiquimod DM1TMA3 MI DEJGDUW DM1TMA3 MN Cytochrome P450 1A2 (CYP1A2) DM1TMA3 MT DME DM1TMA3 MA Metabolism DM1TMA3 RN Summary of information on human CYP enzymes: human P450 metabolism data. Drug Metab Rev. 2002 Feb-May;34(1-2):83-448. DM1TMA3 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=11996015 DM1TMA3 DI DM1TMA3 DM1TMA3 DN Imiquimod DM1TMA3 MI DE4LYSA DM1TMA3 MN Cytochrome P450 3A4 (CYP3A4) DM1TMA3 MT DME DM1TMA3 MA Metabolism DM1TMA3 RN Summary of information on human CYP enzymes: human P450 metabolism data. Drug Metab Rev. 2002 Feb-May;34(1-2):83-448. DM1TMA3 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=11996015 DM1TMA3 DI DM1TMA3 DM1TMA3 DN Imiquimod DM1TMA3 MI TTRJ1K4 DM1TMA3 MN Toll-like receptor 7 (TLR7) DM1TMA3 MT DTT DM1TMA3 MA Agonist DM1TMA3 RN Imiquimod enhances IFN-gamma production and effector function of T cells infiltrating human squamous cell carcinomas of the skin. J Invest Dermatol. 2009 Nov;129(11):2676-85. DM1TMA3 RU https://pubmed.ncbi.nlm.nih.gov/19516264 DMRMFP4 DI DMRMFP4 DMRMFP4 DN Inamrinone Lactate DMRMFP4 MI TTZCG4L DMRMFP4 MN Phosphodiesterase 3 (PDE3) DMRMFP4 MT DTT DMRMFP4 MA Inhibitor DMRMFP4 RN Effects of amrinone on hepatic ischemia-reperfusion injury in rats. J Hepatol. 2002 Jul;37(1):31-8. DMRMFP4 RU https://pubmed.ncbi.nlm.nih.gov/12076859 DM3DSVJ DI DM3DSVJ DM3DSVJ DN Incadronate DM3DSVJ MI TTIKWV4 DM3DSVJ MN Geranyltranstransferase (FDPS) DM3DSVJ MT DTT DM3DSVJ MA Inhibitor DM3DSVJ RN Structure-activity relationships for inhibition of farnesyl diphosphate synthase in vitro and inhibition of bone resorption in vivo by nitrogen-containing bisphosphonates. J Pharmacol Exp Ther. 2001 Feb;296(2):235-42. DM3DSVJ RU https://pubmed.ncbi.nlm.nih.gov/11160603 DMKE6YT DI DMKE6YT DMKE6YT DN Incobotulinum toxin A DMKE6YT MI TTZJD1B DMKE6YT MN Acetylcholine release (Ach rele) DMKE6YT MT DTT DMKE6YT MA Modulator DMKE6YT RN Mullard A: 2010 FDA drug approvals. Nat Rev Drug Discov. 2011 Feb;10(2):82-5. DMKE6YT RU https://pubmed.ncbi.nlm.nih.gov/21283092 DM32GSJ DI DM32GSJ DM32GSJ DN Incruse ellipta DM32GSJ MI DECB0K3 DM32GSJ MN Cytochrome P450 2D6 (CYP2D6) DM32GSJ MT DME DM32GSJ MA Metabolism DM32GSJ RN The combination of umeclidinium bromide and vilanterol in the management of chronic obstructive pulmonary disease: current evidence and future prospects. Ther Adv Respir Dis. 2013 Dec;7(6):311-9. DM32GSJ RU https://www.ncbi.nlm.nih.gov/pubmed/?term=24004659 DM32GSJ DI DM32GSJ DM32GSJ DN Incruse ellipta DM32GSJ MI TTOXS3C DM32GSJ MN Muscarinic acetylcholine receptor (CHRM) DM32GSJ MT DTT DM32GSJ MA Antagonist DM32GSJ RN Clinical pipeline report, company report or official report of GlaxoSmithKline. DM32GSJ RU http://www.gsk.ca/english/html/media-centre/2014-04-17.html DMQJHR7 DI DMQJHR7 DMQJHR7 DN Indacaterol DMQJHR7 MI TT2CJVK DMQJHR7 MN Adrenergic receptor beta-2 (ADRB2) DMQJHR7 MT DTT DMQJHR7 MA Agonist DMQJHR7 RN Emerging drugs in chronic obstructive pulmonary disease. Expert Opin Emerg Drugs. 2009 Mar;14(1):181-94. DMQJHR7 RU https://pubmed.ncbi.nlm.nih.gov/19265487 DMQJHR7 DI DMQJHR7 DMQJHR7 DN Indacaterol DMQJHR7 MI DE4LYSA DMQJHR7 MN Cytochrome P450 3A4 (CYP3A4) DMQJHR7 MT DME DMQJHR7 MA Metabolism DMQJHR7 RN Use of indacaterol for the treatment of COPD: a pharmacokinetic evaluation. Expert Opin Drug Metab Toxicol. 2014 Jan;10(1):129-37. DMQJHR7 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=24295085 DMQJHR7 DI DMQJHR7 DMQJHR7 DN Indacaterol DMQJHR7 MI DTT79CX DMQJHR7 MN Organic cation transporter 1 (SLC22A1) DMQJHR7 MT DTP DMQJHR7 MA Substrate DMQJHR7 RN Identification of novel substrates and structure-activity relationship of cellular uptake mediated by human organic cation transporters 1 and 2. J Med Chem. 2013 Sep 26;56(18):7232-42. DMQJHR7 RU http://www.ncbi.nlm.nih.gov/pubmed/23984907 DMQJHR7 DI DMQJHR7 DMQJHR7 DN Indacaterol DMQJHR7 MI DTUGYRD DMQJHR7 MN P-glycoprotein 1 (ABCB1) DMQJHR7 MT DTP DMQJHR7 MA Substrate DMQJHR7 RN KEGG: new perspectives on genomes, pathways, diseases and drugs. Nucleic Acids Res. 2017 Jan 4;45(D1):D353-D361. (dg:DG01665) DMQJHR7 RU https://www.kegg.jp/dbget-bin/www_bget?dg:DG01665 DMQJHR7 DI DMQJHR7 DMQJHR7 DN Indacaterol DMQJHR7 MI DEYGVN4 DMQJHR7 MN UDP-glucuronosyltransferase 1A1 (UGT1A1) DMQJHR7 MT DME DMQJHR7 MA Metabolism DMQJHR7 RN Use of indacaterol for the treatment of COPD: a pharmacokinetic evaluation. Expert Opin Drug Metab Toxicol. 2014 Jan;10(1):129-37. DMQJHR7 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=24295085 DMGN1PW DI DMGN1PW DMGN1PW DN Indapamide DMGN1PW MI DE4LYSA DMGN1PW MN Cytochrome P450 3A4 (CYP3A4) DMGN1PW MT DME DMGN1PW MA Metabolism DMGN1PW RN Dehydrogenation of the indoline-containing drug 4-chloro-N-(2-methyl-1-indolinyl)-3-sulfamoylbenzamide (indapamide) by CYP3A4: correlation with in silico predictions. Drug Metab Dispos. 2009 Mar;37(3):672-84. DMGN1PW RU https://www.ncbi.nlm.nih.gov/pubmed/?term=19074530 DMGN1PW DI DMGN1PW DMGN1PW DN Indapamide DMGN1PW MI TT846HF DMGN1PW MN Voltage-gated potassium channel Kv7.1 (KCNQ1) DMGN1PW MT DTT DMGN1PW MA Blocker DMGN1PW RN Indapamide induces apoptosis of GH3 pituitary cells independently of its inhibition of voltage-dependent K+ currents. Eur J Pharmacol. 2006 Apr 24;536(1-2):78-84. DMGN1PW RU https://pubmed.ncbi.nlm.nih.gov/16556441 DMUV8OR DI DMUV8OR DMUV8OR DN Indecainide DMUV8OR MI TTZOVE0 DMUV8OR MN Voltage-gated sodium channel alpha Nav1.5 (SCN5A) DMUV8OR MT DTT DMUV8OR MA Blocker DMUV8OR RN Electrophysiological studies of indecainide hydrochloride, a new antiarrhythmic agent, in canine cardiac tissues. J Cardiovasc Pharmacol. 1984 Jul-Aug;6(4):614-21. DMUV8OR RU https://pubmed.ncbi.nlm.nih.gov/6206315 DMWO3N6 DI DMWO3N6 DMWO3N6 DN Indeloxazine DMWO3N6 MI TTGP7BY DMWO3N6 MN Monoamine oxidase type B (MAO-B) DMWO3N6 MT DTT DMWO3N6 MA Modulator DMWO3N6 RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015 DMWO3N6 RU https://www.accessdata.fda.gov/scripts/cder/drugsatfda/ DM0T3YH DI DM0T3YH DM0T3YH DN Indinavir DM0T3YH MI DECB0K3 DM0T3YH MN Cytochrome P450 2D6 (CYP2D6) DM0T3YH MT DME DM0T3YH MA Metabolism DM0T3YH RN Inhibition of desipramine hydroxylation (Cytochrome P450-2D6) in vitro by quinidine and by viral protease inhibitors: relation to drug interactions in vivo. J Pharm Sci. 1998 Oct;87(10):1184-9. DM0T3YH RU https://www.ncbi.nlm.nih.gov/pubmed/?term=9758674 DM0T3YH DI DM0T3YH DM0T3YH DN Indinavir DM0T3YH MI DE4LYSA DM0T3YH MN Cytochrome P450 3A4 (CYP3A4) DM0T3YH MT DME DM0T3YH MA Metabolism DM0T3YH RN Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. 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DM0T3YH RU https://www.ncbi.nlm.nih.gov/pubmed/?term=16433896 DM0T3YH DI DM0T3YH DM0T3YH DN Indinavir DM0T3YH MI TT5FNQT DM0T3YH MN Human immunodeficiency virus Protease (HIV PR) DM0T3YH MT DTT DM0T3YH MA Inhibitor DM0T3YH RN Quantification of HIV protease inhibitors and non-nucleoside reverse transcriptase inhibitors in peripheral blood mononuclear cell lysate using liq... J Chromatogr B Analyt Technol Biomed Life Sci. 2009 Feb 15;877(5-6):575-80. DM0T3YH RU https://pubmed.ncbi.nlm.nih.gov/19168402 DM0T3YH DI DM0T3YH DM0T3YH DN Indinavir DM0T3YH MI DTSYQGK DM0T3YH MN Multidrug resistance-associated protein 1 (ABCC1) DM0T3YH MT DTP DM0T3YH MA Substrate DM0T3YH RN Human intestinal transporter database: QSAR modeling and virtual profiling of drug uptake, efflux and interactions. Pharm Res. 2013 Apr;30(4):996-1007. 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DM2NQUY RU https://doi.org/10.1016/j.jhep.2012.01.031 DMSC4A7 DI DMSC4A7 DMSC4A7 DN Indomethacin DMSC4A7 MI DE5IED8 DMSC4A7 MN Cytochrome P450 2C9 (CYP2C9) DMSC4A7 MT DME DMSC4A7 MA Metabolism DMSC4A7 RN Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. DMSC4A7 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=19515014 DMSC4A7 DI DMSC4A7 DMSC4A7 DN Indomethacin DMSC4A7 MI DEGTFWK DMSC4A7 MN Mephenytoin 4-hydroxylase (CYP2C19) DMSC4A7 MT DME DMSC4A7 MA Metabolism DMSC4A7 RN Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. DMSC4A7 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=19515014 DMSC4A7 DI DMSC4A7 DMSC4A7 DN Indomethacin DMSC4A7 MI DTUGYRD DMSC4A7 MN P-glycoprotein 1 (ABCB1) DMSC4A7 MT DTP DMSC4A7 MA Substrate DMSC4A7 RN Indomethacin induces apoptosis via a MRP1-dependent mechanism in doxorubicin-resistant small-cell lung cancer cells overexpressing MRP1. Br J Cancer. 2007 Oct 22;97(8):1077-83. DMSC4A7 RU http://www.ncbi.nlm.nih.gov/pubmed/17940500 DMSC4A7 DI DMSC4A7 DMSC4A7 DN Indomethacin DMSC4A7 MI TTVKILB DMSC4A7 MN Prostaglandin G/H synthase 2 (COX-2) DMSC4A7 MT DTT DMSC4A7 MA Modulator DMSC4A7 RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. DMSC4A7 RU https://www.fda.gov/ DMSC4A7 DI DMSC4A7 DMSC4A7 DN Indomethacin DMSC4A7 MI DEYGVN4 DMSC4A7 MN UDP-glucuronosyltransferase 1A1 (UGT1A1) DMSC4A7 MT DME DMSC4A7 MA Metabolism DMSC4A7 RN Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. DMSC4A7 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=19515014 DMSC4A7 DI DMSC4A7 DMSC4A7 DN Indomethacin DMSC4A7 MI DE85D2P DMSC4A7 MN UDP-glucuronosyltransferase 1A9 (UGT1A9) DMSC4A7 MT DME DMSC4A7 MA Metabolism DMSC4A7 RN Contribution of UDP-glucuronosyltransferases 1A9 and 2B7 to the glucuronidation of indomethacin in the human liver. Eur J Clin Pharmacol. 2007 Mar;63(3):289-96. 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U.S. Department of Health Human Services. 2020 DMI0RHA RU https://www.accessdata.fda.gov/drugsatfda_docs/label/2020/761142s000lbl.pdf DMH7OIA DI DMH7OIA DMH7OIA DN Infliximab DMH7OIA MI TTF8CQI DMH7OIA MN Tumor necrosis factor (TNF) DMH7OIA MT DTT DMH7OIA RN Drug insight: tumor necrosis factor-converting enzyme as a pharmaceutical target for rheumatoid arthritis. Nat Clin Pract Rheumatol. 2008 Jun;4(6):300-9. DMH7OIA RU https://pubmed.ncbi.nlm.nih.gov/18414459 DMK1CZJ DI DMK1CZJ DMK1CZJ DN Ingenol mebutate DMK1CZJ MI DTUGYRD DMK1CZJ MN P-glycoprotein 1 (ABCB1) DMK1CZJ MT DTP DMK1CZJ MA Substrate DMK1CZJ RN The skin cancer chemotherapeutic agent ingenol-3-angelate (PEP005) is a substrate for the epidermal multidrug transporter (ABCB1) and targets tumor vasculature. Cancer Res. 2010 Jun 1;70(11):4509-19. 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DMB7CE0 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=15850385 DMB7CE0 DI DMB7CE0 DMB7CE0 DN Insulin DMB7CE0 MI DE0QGHP DMB7CE0 MN Insulin-degrading enzyme (ide) DMB7CE0 MT DME DMB7CE0 MA Metabolism DMB7CE0 RN Vibrio vulnificus secretes an insulin-degrading enzyme that promotes bacterial proliferation in vivo. J Biol Chem. 2015 Jul 24;290(30):18708-20. DMB7CE0 RU https://pubmed.ncbi.nlm.nih.gov/26041774 DMPL395 DI DMPL395 DMPL395 DN Insulin degludec DMPL395 MI TTZOPHG DMPL395 MN Insulin (INS) DMPL395 MT DTT DMPL395 MA Modulator DMPL395 RN Radium 223 dichloride for prostate cancer treatment. Drug Des Devel Ther. 2017 Sep 6;11:2643-2651. DMPL395 RU https://pubmed.ncbi.nlm.nih.gov/28919714 DM79NZ5 DI DM79NZ5 DM79NZ5 DN Insulin determir DM79NZ5 MI TTZOPHG DM79NZ5 MN Insulin (INS) DM79NZ5 MT DTT DM79NZ5 MA Modulator DM79NZ5 RN 2005 approvals: Safety first. Nature Reviews Drug Discovery 5, 92-93 (February 2006). DM79NZ5 RU http://www.nature.com/nrd/journal/v11/n1/full/nrd3645.html DM5XHVR DI DM5XHVR DM5XHVR DN Insulin Lyspro recombinant DM5XHVR MI TTCBFJO DM5XHVR MN Insulin receptor (INSR) DM5XHVR MT DTT DM5XHVR MA Binder DM5XHVR RN Knockouts model the 100 best-selling drugs--will they model the next 100 Nat Rev Drug Discov. 2003 Jan;2(1):38-51. DM5XHVR RU https://pubmed.ncbi.nlm.nih.gov/12509758 DMYVP5G DI DMYVP5G DMYVP5G DN Insulin recombinant DMYVP5G MI TTCBFJO DMYVP5G MN Insulin receptor (INSR) DMYVP5G MT DTT DMYVP5G MA Binder DMYVP5G RN Knockouts model the 100 best-selling drugs--will they model the next 100 Nat Rev Drug Discov. 2003 Jan;2(1):38-51. DMYVP5G RU https://pubmed.ncbi.nlm.nih.gov/12509758 DMW8KI7 DI DMW8KI7 DMW8KI7 DN Insulin Susp Isophane Recombinant Human DMW8KI7 MI TTZOPHG DMW8KI7 MN Insulin (INS) DMW8KI7 MT DTT DMW8KI7 MA Modulator DMW8KI7 RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. DMW8KI7 RU https://www.fda.gov/ DM0NATE DI DM0NATE DM0NATE DN Insulin Susp Protamine Zinc Beef/Pork DM0NATE MI TTZOPHG DM0NATE MN Insulin (INS) DM0NATE MT DTT DM0NATE MA Modulator DM0NATE RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. DM0NATE RU https://www.fda.gov/ DM6MO9X DI DM6MO9X DM6MO9X DN Insulin Zinc Susp Recombinant Human DM6MO9X MI TTZOPHG DM6MO9X MN Insulin (INS) DM6MO9X MT DTT DM6MO9X MA Modulator DM6MO9X RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. DM6MO9X RU https://www.fda.gov/ DMO95XI DI DMO95XI DMO95XI DN Insulin, porcine DMO95XI MI TTCBFJO DMO95XI MN Insulin receptor (INSR) DMO95XI MT DTT DMO95XI MA Binder DMO95XI RN Acidic residues on the N-terminus of proinsulin C-Peptide are important for the folding of insulin precursor. J Biochem. 2002 Jun;131(6):855-9. DMO95XI RU https://pubmed.ncbi.nlm.nih.gov/12038982 DMX7V28 DI DMX7V28 DMX7V28 DN Insulin-aspart DMX7V28 MI TTZOPHG DMX7V28 MN Insulin (INS) DMX7V28 MT DTT DMX7V28 MA Modulator DMX7V28 RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. DMX7V28 RU https://www.fda.gov/ DMOA4VW DI DMOA4VW DMOA4VW DN Insulin-detemir DMOA4VW MI TTZOPHG DMOA4VW MN Insulin (INS) DMOA4VW MT DTT DMOA4VW MA Modulator DMOA4VW RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. DMOA4VW RU https://www.fda.gov/ DMR4HIW DI DMR4HIW DMR4HIW DN Insulin-glargine DMR4HIW MI TTZOPHG DMR4HIW MN Insulin (INS) DMR4HIW MT DTT DMR4HIW MA Modulator DMR4HIW RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. DMR4HIW RU https://www.fda.gov/ DMQI0FU DI DMQI0FU DMQI0FU DN Insulin-glulisine DMQI0FU MI TTCBFJO DMQI0FU MN Insulin receptor (INSR) DMQI0FU MT DTT DMQI0FU MA Binder DMQI0FU RN Insulin glulisine: a review of its use in the management of diabetes mellitus. Drugs. 2009;69(8):1035-57. DMQI0FU RU https://pubmed.ncbi.nlm.nih.gov/19496630 DM4O90W DI DM4O90W DM4O90W DN Insulin-lispro DM4O90W MI TTCBFJO DM4O90W MN Insulin receptor (INSR) DM4O90W MT DTT DM4O90W MA Binder DM4O90W RN Hope for insulin mimetic oral antidiabetic drugs. Eur J Endocrinol. 1999 Dec;141(6):561-2. DM4O90W RU https://pubmed.ncbi.nlm.nih.gov/10601956 DMSTA36 DI DMSTA36 DMSTA36 DN Intedanib DMSTA36 MI TTRLW2X DMSTA36 MN Fibroblast growth factor receptor 1 (FGFR1) DMSTA36 MT DTT DMSTA36 MA Modulator DMSTA36 RN 2014 FDA drug approvals. Nat Rev Drug Discov. 2015 Feb;14(2):77-81. DMSTA36 RU https://pubmed.ncbi.nlm.nih.gov/25633781 DMSTA36 DI DMSTA36 DMSTA36 DN Intedanib DMSTA36 MI TTGJCWZ DMSTA36 MN Fms-like tyrosine kinase 3 (FLT-3) DMSTA36 MT DTT DMSTA36 MA Inhibitor DMSTA36 RN 2014 FDA drug approvals. Nat Rev Drug Discov. 2015 Feb;14(2):77-81. DMSTA36 RU https://pubmed.ncbi.nlm.nih.gov/25633781 DMSTA36 DI DMSTA36 DMSTA36 DN Intedanib DMSTA36 MI DTUGYRD DMSTA36 MN P-glycoprotein 1 (ABCB1) DMSTA36 MT DTP DMSTA36 MA Substrate DMSTA36 RN Effects of Ketoconazole and Rifampicin on the Pharmacokinetics of Nintedanib in Healthy Subjects. Eur J Drug Metab Pharmacokinet. 2018 Oct;43(5):533-541. DMSTA36 RU http://www.ncbi.nlm.nih.gov/pubmed/29500603 DMSTA36 DI DMSTA36 DMSTA36 DN Intedanib DMSTA36 MI TTI2WET DMSTA36 MN Platelet-derived growth factor receptor (PDGFR) DMSTA36 MT DTT DMSTA36 MA Modulator DMSTA36 RN 2014 FDA drug approvals. Nat Rev Drug Discov. 2015 Feb;14(2):77-81. DMSTA36 RU https://pubmed.ncbi.nlm.nih.gov/25633781 DMSTA36 DI DMSTA36 DMSTA36 DN Intedanib DMSTA36 MI TTVJ1D8 DMSTA36 MN Vascular endothelial growth factor receptor (VEGFR) DMSTA36 MT DTT DMSTA36 MA Modulator DMSTA36 RN 2014 FDA drug approvals. Nat Rev Drug Discov. 2015 Feb;14(2):77-81. DMSTA36 RU https://pubmed.ncbi.nlm.nih.gov/25633781 DMUTZ8S DI DMUTZ8S DMUTZ8S DN Interferon Alfa-2a, Recombinant DMUTZ8S MI TTGJVQM DMUTZ8S MN Fibroblast growth factor receptor 2 (FGFR2) DMUTZ8S MT DTT DMUTZ8S MA Binder DMUTZ8S RN DrugBank: a knowledgebase for drugs, drug actions and drug targets. Nucleic Acids Res. 2008 Jan;36(Database issue):D901-6. DMUTZ8S RU https://pubmed.ncbi.nlm.nih.gov/18048412 DMWCQP4 DI DMWCQP4 DMWCQP4 DN Interferon alfa-2B DMWCQP4 MI TTSIUJ9 DMWCQP4 MN Interferon-alpha 2 (IFNA2) DMWCQP4 MT DTT DMWCQP4 MA Modulator DMWCQP4 RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. DMWCQP4 RU https://www.fda.gov/ DM3TPY8 DI DM3TPY8 DM3TPY8 DN Interferon Alfa-2b, Recombinant DM3TPY8 MI TTMQB37 DM3TPY8 MN Interferon alpha/beta receptor 2 (IFNAR2) DM3TPY8 MT DTT DM3TPY8 MA Binder DM3TPY8 RN Successful treatment of relapsed Philadelphia chromosome-positive acute lymphoblastic leukemia with T315I mutation after haplo-identical hematopoie... Leuk Res. 2009 Aug;33(8):e111-3. DM3TPY8 RU https://pubmed.ncbi.nlm.nih.gov/19362369 DM90WJH DI DM90WJH DM90WJH DN Interferon alfacon-1 DM90WJH MI TTMQB37 DM90WJH MN Interferon alpha/beta receptor 2 (IFNAR2) DM90WJH MT DTT DM90WJH MA Binder DM90WJH RN Retreating chronic hepatitis C with daily interferon alfacon-1/ribavirin after nonresponse to pegylated interferon/ribavirin: DIRECT results. Hepatology. 2009 Jun;49(6):1838-46. DM90WJH RU https://pubmed.ncbi.nlm.nih.gov/19291790 DM4AK0Q DI DM4AK0Q DM4AK0Q DN Interferon alfa-n1 DM4AK0Q MI TTMQB37 DM4AK0Q MN Interferon alpha/beta receptor 2 (IFNAR2) DM4AK0Q MT DTT DM4AK0Q MA Binder DM4AK0Q RN Lymphoblastoid interferon alfa-n1 improves the long-term response to a 6-month course of treatment in chronic hepatitis C compared with recombinant interferon alfa-2b: results of an international randomized controlled trial. Clinical Advisory Group for the Hepatitis C Comparative Study. Hepatology. 1998 Apr;27(4):1121-7. DM4AK0Q RU https://pubmed.ncbi.nlm.nih.gov/9537453 DMTZNQ9 DI DMTZNQ9 DMTZNQ9 DN Interferon alfa-n3 DMTZNQ9 MI TT95SOA DMTZNQ9 MN Interferon alpha (IFNA) DMTZNQ9 MT DTT DMTZNQ9 MA Modulator DMTZNQ9 RN Clinical pipeline report, company report or official report of Hemispherx Biopharma. DMTZNQ9 RU http://www.hemispherx.net/content/rnd/ DM1A6RV DI DM1A6RV DM1A6RV DN Interferon beta-1a DM1A6RV MI TT4TZ8J DM1A6RV MN Interferon-beta (IFNB1) DM1A6RV MT DTT DM1A6RV MA Modulator DM1A6RV RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. DM1A6RV RU https://www.fda.gov/ DMCN61Z DI DMCN61Z DMCN61Z DN Interferon beta-1b DMCN61Z MI TTMQB37 DMCN61Z MN Interferon alpha/beta receptor 2 (IFNAR2) DMCN61Z MT DTT DMCN61Z MA Binder DMCN61Z RN Interferon-beta(1b) Treatment in Neuromyelitis Optica. Eur Neurol. 2009 Jul 7;62(3):167-170. DMCN61Z RU https://pubmed.ncbi.nlm.nih.gov/19590215 DMWUMRL DI DMWUMRL DMWUMRL DN Interferon gamma-1b DMWUMRL MI TT13TL0 DMWUMRL MN Interferon gamma receptor (IFNGR2) DMWUMRL MT DTT DMWUMRL MA Binder DMWUMRL RN Genetic polymorphisms in the promoter of the interferon gamma receptor 1 gene are associated with atopic cataracts. Invest Ophthalmol Vis Sci. 2007 Feb;48(2):583-9. DMWUMRL RU https://pubmed.ncbi.nlm.nih.gov/17251453 DM1Y69Q DI DM1Y69Q DM1Y69Q DN Interleukin-3 DM1Y69Q MI TT5TQ2W DM1Y69Q MN Granulocyte colony-stimulating factor (CSF3) DM1Y69Q MT DTT DM1Y69Q MA Modulator DM1Y69Q RN Interleukin 3: from colony-stimulating factor to pluripotent immunoregulatory cytokine. Int J Immunopharmacol. 1992 Apr;14(3):421-30. DM1Y69Q RU https://pubmed.ncbi.nlm.nih.gov/1618595 DMS6ZI0 DI DMS6ZI0 DMS6ZI0 DN Inulin DMS6ZI0 MI DE4EX78 DMS6ZI0 MN Beta-fructofuranosidase (BFRU) DMS6ZI0 MT DME DMS6ZI0 MA Metabolism DMS6ZI0 RN Substrate-driven gene expression in Roseburia inulinivorans: importance of inducible enzymes in the utilization of inulin and starch. Proc Natl Acad Sci U S A. 2011 Mar 15;108 Suppl 1:4672-9. DMS6ZI0 RU https://pubmed.ncbi.nlm.nih.gov/20679207 DM1Y2JH DI DM1Y2JH DM1Y2JH DN Inulin DM1Y2JH MI TTZOPHG DM1Y2JH MN Insulin (INS) DM1Y2JH MT DTT DM1Y2JH MA Modulator DM1Y2JH RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. DM1Y2JH RU https://www.fda.gov/ DM80OEZ DI DM80OEZ DM80OEZ DN Iobenguane I-123 DM80OEZ MI TTAWNKZ DM80OEZ MN Norepinephrine transporter (NET) DM80OEZ MT DTT DM80OEZ MA Inhibitor DM80OEZ RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 926). DM80OEZ RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=926 DMXIQYS DI DMXIQYS DMXIQYS DN Iodipamide DMXIQYS MI TTFNGC9 DMXIQYS MN Serum albumin (ALB) DMXIQYS MT DTT DMXIQYS MA Binder DMXIQYS RN Determining binding sites of drugs on human serum albumin using FIA-QCM. Biosens Bioelectron. 2008 Sep 15;24(1):48-54. DMXIQYS RU https://pubmed.ncbi.nlm.nih.gov/18436441 DMNARJT DI DMNARJT DMNARJT DN Ioflupane I-123 DMNARJT MI TTVBI8W DMNARJT MN Dopamine transporter (DAT) DMNARJT MT DTT DMNARJT MA Modulator DMNARJT RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015 DMNARJT RU https://www.accessdata.fda.gov/scripts/cder/drugsatfda/ DMLZTP9 DI DMLZTP9 DMLZTP9 DN Ipecac DMLZTP9 MI DECB0K3 DMLZTP9 MN Cytochrome P450 2D6 (CYP2D6) DMLZTP9 MT DME DMLZTP9 MA Metabolism DMLZTP9 RN Medical Toxicology of Drug Abuse: Synthesized Chemicals and Psychoactive Plants. doi: 10.1002/9781118105955.ch13 DMLZTP9 RU https://onlinelibrary.wiley.com/doi/abs/10.1002/9781118105955.ch13 DMWA24P DI DMWA24P DMWA24P DN IPI-145 DMWA24P MI TTGBPJE DMWA24P MN PI3-kinase delta (PIK3CD) DMWA24P MT DTT DMWA24P MA Modulator DMWA24P RN PI3K-delta and PI3K-gamma inhibition by IPI-145 abrogates immune responses and suppresses activity in autoimmune and inflammatory disease models. Chem Biol. 2013 Nov 21;20(11):1364-74. DMWA24P RU https://pubmed.ncbi.nlm.nih.gov/24211136 DMWA24P DI DMWA24P DMWA24P DN IPI-145 DMWA24P MI TTHBTOP DMWA24P MN PI3-kinase gamma (PIK3CG) DMWA24P MT DTT DMWA24P MA Modulator DMWA24P RN PI3K-delta and PI3K-gamma inhibition by IPI-145 abrogates immune responses and suppresses activity in autoimmune and inflammatory disease models. Chem Biol. 2013 Nov 21;20(11):1364-74. DMWA24P RU https://pubmed.ncbi.nlm.nih.gov/24211136 DMJTIYK DI DMJTIYK DMJTIYK DN Ipilimumab DMJTIYK MI TTI2S1D DMJTIYK MN Cytotoxic T-lymphocyte protein 4 (CTLA-4) DMJTIYK MT DTT DMJTIYK RN Mullard A: 2010 FDA drug approvals. Nat Rev Drug Discov. 2011 Feb;10(2):82-5. DMJTIYK RU https://pubmed.ncbi.nlm.nih.gov/21283092 DMFQ320 DI DMFQ320 DMFQ320 DN Ipratropium DMFQ320 MI TTQ13Z5 DMFQ320 MN Muscarinic acetylcholine receptor M3 (CHRM3) DMFQ320 MT DTT DMFQ320 MA Modulator DMFQ320 RN Role of parasympathetic nerves and muscarinic receptors in allergy and asthma.Chem Immunol Allergy.2012;98:48-69. DMFQ320 RU https://www.ncbi.nlm.nih.gov/pubmed/22767057 DMFQ320 DI DMFQ320 DMFQ320 DN Ipratropium DMFQ320 MI DTT79CX DMFQ320 MN Organic cation transporter 1 (SLC22A1) DMFQ320 MT DTP DMFQ320 MA Substrate DMFQ320 RN Identification of novel substrates and structure-activity relationship of cellular uptake mediated by human organic cation transporters 1 and 2. J Med Chem. 2013 Sep 26;56(18):7232-42. DMFQ320 RU http://www.ncbi.nlm.nih.gov/pubmed/23984907 DMFQ320 DI DMFQ320 DMFQ320 DN Ipratropium DMFQ320 MI DT2EG60 DMFQ320 MN Organic cation/carnitine transporter 1 (SLC22A4) DMFQ320 MT DTP DMFQ320 MA Substrate DMFQ320 RN Transport of ipratropium, an anti-chronic obstructive pulmonary disease drug, is mediated by organic cation/carnitine transporters in human bronchial epithelial cells: implications for carrier-mediated pulmonary absorption. Mol Pharm. 2010 Feb 1;7(1):187-95. DMFQ320 RU http://www.ncbi.nlm.nih.gov/pubmed/20020740 DMFQ320 DI DMFQ320 DMFQ320 DN Ipratropium DMFQ320 MI DT3HUVD DMFQ320 MN Organic cation/carnitine transporter 2 (SLC22A5) DMFQ320 MT DTP DMFQ320 MA Substrate DMFQ320 RN Transport of ipratropium, an anti-chronic obstructive pulmonary disease drug, is mediated by organic cation/carnitine transporters in human bronchial epithelial cells: implications for carrier-mediated pulmonary absorption. Mol Pharm. 2010 Feb 1;7(1):187-95. DMFQ320 RU http://www.ncbi.nlm.nih.gov/pubmed/20020740 DM0IO13 DI DM0IO13 DM0IO13 DN Ipriflavone DM0IO13 MI DE6OQ3W DM0IO13 MN Cytochrome P450 1A1 (CYP1A1) DM0IO13 MT DME DM0IO13 MA Metabolism DM0IO13 RN Effects of enzyme inducers and inhibitors on the pharmacokinetics of intravenous ipriflavone in rats. J Pharm Pharmacol. 2006 Apr;58(4):449-57. DM0IO13 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=16597362 DM0IO13 DI DM0IO13 DM0IO13 DN Ipriflavone DM0IO13 MI DEJGDUW DM0IO13 MN Cytochrome P450 1A2 (CYP1A2) DM0IO13 MT DME DM0IO13 MA Metabolism DM0IO13 RN Characterization of cytochrome P450s mediating ipriflavone metabolism in human liver microsomes. Xenobiotica. 2007 Mar;37(3):246-59. DM0IO13 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=17624023 DM0IO13 DI DM0IO13 DM0IO13 DN Ipriflavone DM0IO13 MI DE4LYSA DM0IO13 MN Cytochrome P450 3A4 (CYP3A4) DM0IO13 MT DME DM0IO13 MA Metabolism DM0IO13 RN Pharmacokinetics of ipriflavone and metabolites after oral administration of a corn-oil suspension relative to the Osteofix tablet. Am J Ther. 1997 Jul-Aug;4(7-8):229-38. DM0IO13 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=10423615 DMTP1DC DI DMTP1DC DMTP1DC DN Irbesartan DMTP1DC MI TT8DBY3 DMTP1DC MN Angiotensin II receptor type-1 (AGTR1) DMTP1DC MT DTT DMTP1DC MA Antagonist DMTP1DC RN Radioligand binding assays: application of [(125)I]angiotensin II receptor binding. Methods Mol Biol. 2009;552:131-41. DMTP1DC RU https://pubmed.ncbi.nlm.nih.gov/19513646 DMTP1DC DI DMTP1DC DMTP1DC DN Irbesartan DMTP1DC MI DES5XRU DMTP1DC MN Cytochrome P450 2C8 (CYP2C8) DMTP1DC MT DME DMTP1DC MA Metabolism DMTP1DC RN Examination of 209 drugs for inhibition of cytochrome P450 2C8. J Clin Pharmacol. 2005 Jan;45(1):68-78. DMTP1DC RU https://www.ncbi.nlm.nih.gov/pubmed/?term=15601807 DMTP1DC DI DMTP1DC DMTP1DC DN Irbesartan DMTP1DC MI DE5IED8 DMTP1DC MN Cytochrome P450 2C9 (CYP2C9) DMTP1DC MT DME DMTP1DC MA Metabolism DMTP1DC RN Rapid detection of the known SNPs of CYP2C9 using oligonucleotide microarray. World J Gastroenterol. 2003 Jun;9(6):1342-6. DMTP1DC RU https://www.ncbi.nlm.nih.gov/pubmed/?term=12800253 DMTP1DC DI DMTP1DC DMTP1DC DN Irbesartan DMTP1DC MI DE4LYSA DMTP1DC MN Cytochrome P450 3A4 (CYP3A4) DMTP1DC MT DME DMTP1DC MA Metabolism DMTP1DC RN Drug interactions with irbesartan. Clin Pharmacokinet. 2001;40(8):605-14. DMTP1DC RU https://www.ncbi.nlm.nih.gov/pubmed/?term=11523726 DMTP1DC DI DMTP1DC DMTP1DC DN Irbesartan DMTP1DC MI DT9G7XN DMTP1DC MN Peptide transporter 1 (SLC15A1) DMTP1DC MT DTP DMTP1DC MA Substrate DMTP1DC RN High-affinity interaction of sartans with H+/peptide transporters. Drug Metab Dispos. 2009 Jan;37(1):143-9. DMTP1DC RU http://www.ncbi.nlm.nih.gov/pubmed/18824524 DMTP1DC DI DMTP1DC DMTP1DC DN Irbesartan DMTP1DC MI DE073H6 DMTP1DC MN Prostaglandin G/H synthase 1 (COX-1) DMTP1DC MT DME DMTP1DC MA Metabolism DMTP1DC RN Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. DMTP1DC RU https://www.ncbi.nlm.nih.gov/pubmed/?term=19515014 DMTP1DC DI DMTP1DC DMTP1DC DN Irbesartan DMTP1DC MI DEF2WXN DMTP1DC MN UDP-glucuronosyltransferase 1A3 (UGT1A3) DMTP1DC MT DME DMTP1DC MA Metabolism DMTP1DC RN Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. DMTP1DC RU https://www.ncbi.nlm.nih.gov/pubmed/?term=19515014 DMP6SC2 DI DMP6SC2 DMP6SC2 DN Irinotecan DMP6SC2 MI DE9RA0I DMP6SC2 MN Beta-glucuronidase (uidA) DMP6SC2 MT DME DMP6SC2 MA Metabolism DMP6SC2 RN Involvement of beta-glucuronidase in intestinal microflora in the intestinal toxicity of the antitumor camptothecin derivative irinotecan hydrochloride (CPT-11) in rats. Cancer Res. 1996 Aug 15;56(16):3752-7. DMP6SC2 RU https://pubmed.ncbi.nlm.nih.gov/8706020 DMP6SC2 DI DMP6SC2 DMP6SC2 DN Irinotecan DMP6SC2 MI DTI7UX6 DMP6SC2 MN Breast cancer resistance protein (ABCG2) DMP6SC2 MT DTP DMP6SC2 MA Substrate DMP6SC2 RN Cyclosporin A, tacrolimus and sirolimus are potent inhibitors of the human breast cancer resistance protein (ABCG2) and reverse resistance to mitoxantrone and topotecan. Cancer Chemother Pharmacol. 2006 Sep;58(3):374-83. DMP6SC2 RU http://www.ncbi.nlm.nih.gov/pubmed/16404634 DMP6SC2 DI DMP6SC2 DMP6SC2 DN Irinotecan DMP6SC2 MI DEB30C5 DMP6SC2 MN Carboxylesterase 1 (CES1) DMP6SC2 MT DME DMP6SC2 MA Metabolism DMP6SC2 RN Irinotecan and its active metabolite, SN-38: review of bioanalytical methods and recent update from clinical pharmacology perspectives. Biomed Chromatogr. 2010 Jan;24(1):104-23. DMP6SC2 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=19852077 DMP6SC2 DI DMP6SC2 DMP6SC2 DN Irinotecan DMP6SC2 MI DETHCPD DMP6SC2 MN Carboxylesterase 2 (CES2) DMP6SC2 MT DME DMP6SC2 MA Metabolism DMP6SC2 RN Hydrolysis of irinotecan and its oxidative metabolites, 7-ethyl-10-[4-N-(5-aminopentanoic acid)-1-piperidino] carbonyloxycamptothecin and 7-ethyl-10-[4-(1-piperidino)-1-amino]-carbonyloxycamptothecin, by human carboxylesterases CES1A1, CES2, and a newly expressed carboxylesterase isoenzyme, CES3. Drug Metab Dispos. 2004 May;32(5):505-11. DMP6SC2 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=15100172 DMP6SC2 DI DMP6SC2 DMP6SC2 DN Irinotecan DMP6SC2 MI DEMI4VE DMP6SC2 MN Carboxylesterase 3 (CES3) DMP6SC2 MT DME DMP6SC2 MA Metabolism DMP6SC2 RN Hydrolysis of irinotecan and its oxidative metabolites, 7-ethyl-10-[4-N-(5-aminopentanoic acid)-1-piperidino] carbonyloxycamptothecin and 7-ethyl-10-[4-(1-piperidino)-1-amino]-carbonyloxycamptothecin, by human carboxylesterases CES1A1, CES2, and a newly expressed carboxylesterase isoenzyme, CES3. Drug Metab Dispos. 2004 May;32(5):505-11. DMP6SC2 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=15100172 DMP6SC2 DI DMP6SC2 DMP6SC2 DN Irinotecan DMP6SC2 MI DEPKLMQ DMP6SC2 MN Cytochrome P450 2B6 (CYP2B6) DMP6SC2 MT DME DMP6SC2 MA Metabolism DMP6SC2 RN Drugs that may have potential CYP2B6 interactions. DMP6SC2 RU https://drug-interactions.medicine.iu.edu/MainTable.aspx DMP6SC2 DI DMP6SC2 DMP6SC2 DN Irinotecan DMP6SC2 MI DE4LYSA DMP6SC2 MN Cytochrome P450 3A4 (CYP3A4) DMP6SC2 MT DME DMP6SC2 MA Metabolism DMP6SC2 RN Irinotecan and its active metabolite, SN-38: review of bioanalytical methods and recent update from clinical pharmacology perspectives. Biomed Chromatogr. 2010 Jan;24(1):104-23. DMP6SC2 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=19852077 DMP6SC2 DI DMP6SC2 DMP6SC2 DN Irinotecan DMP6SC2 MI DEIBDNY DMP6SC2 MN Cytochrome P450 3A5 (CYP3A5) DMP6SC2 MT DME DMP6SC2 MA Metabolism DMP6SC2 RN Pharmacogenetics of irinotecan metabolism and transport: an update. Toxicol In Vitro. 2006 Mar;20(2):163-75. DMP6SC2 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=16271446 DMP6SC2 DI DMP6SC2 DMP6SC2 DN Irinotecan DMP6SC2 MI DERD86B DMP6SC2 MN Cytochrome P450 3A7 (CYP3A7) DMP6SC2 MT DME DMP6SC2 MA Metabolism DMP6SC2 RN Drug Interactions Flockhart Table DMP6SC2 RU https://drug-interactions.medicine.iu.edu/Main-Table.aspx DMP6SC2 DI DMP6SC2 DMP6SC2 DN Irinotecan DMP6SC2 MI TTGTQHC DMP6SC2 MN DNA topoisomerase I (TOP1) DMP6SC2 MT DTT DMP6SC2 MA Modulator DMP6SC2 RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. DMP6SC2 RU https://www.fda.gov/ DMP6SC2 DI DMP6SC2 DMP6SC2 DN Irinotecan DMP6SC2 MI DTSYQGK DMP6SC2 MN Multidrug resistance-associated protein 1 (ABCC1) DMP6SC2 MT DTP DMP6SC2 MA Substrate DMP6SC2 RN ATP-Dependent efflux of CPT-11 and SN-38 by the multidrug resistance protein (MRP) and its inhibition by PAK-104P. Mol Pharmacol. 1999 May;55(5):921-8. DMP6SC2 RU http://molpharm.aspetjournals.org/content/55/5/921 DMP6SC2 DI DMP6SC2 DMP6SC2 DN Irinotecan DMP6SC2 MI DTFI42L DMP6SC2 MN Multidrug resistance-associated protein 2 (ABCC2) DMP6SC2 MT DTP DMP6SC2 MA Substrate DMP6SC2 RN Intestinal transport of irinotecan in Caco-2 cells and MDCK II cells overexpressing efflux transporters Pgp, cMOAT, and MRP1. Drug Metab Dispos. 2002 Jul;30(7):763-70. DMP6SC2 RU http://www.ncbi.nlm.nih.gov/pubmed/12065434 DMP6SC2 DI DMP6SC2 DMP6SC2 DN Irinotecan DMP6SC2 MI DTCSGPB DMP6SC2 MN Multidrug resistance-associated protein 4 (ABCC4) DMP6SC2 MT DTP DMP6SC2 MA Substrate DMP6SC2 RN P-glycoprotein, but not multidrug resistance protein 4, plays a role in the systemic clearance of irinotecan and SN-38 in mice. Drug Metab Lett. 2010 Dec;4(4):195-201. DMP6SC2 RU http://www.ncbi.nlm.nih.gov/pubmed/20583968 DMP6SC2 DI DMP6SC2 DMP6SC2 DN Irinotecan DMP6SC2 MI DTYVM24 DMP6SC2 MN Multidrug resistance-associated protein 5 (ABCC5) DMP6SC2 MT DTP DMP6SC2 MA Substrate DMP6SC2 RN Celecoxib upregulates multidrug resistance proteins in colon cancer: lack of synergy with standard chemotherapy. Curr Cancer Drug Targets. 2008 Aug;8(5):414-20. DMP6SC2 RU http://www.ncbi.nlm.nih.gov/pubmed/18690847 DMP6SC2 DI DMP6SC2 DMP6SC2 DN Irinotecan DMP6SC2 MI DTUGYRD DMP6SC2 MN P-glycoprotein 1 (ABCB1) DMP6SC2 MT DTP DMP6SC2 MA Substrate DMP6SC2 RN Intestinal transport of irinotecan in Caco-2 cells and MDCK II cells overexpressing efflux transporters Pgp, cMOAT, and MRP1. Drug Metab Dispos. 2002 Jul;30(7):763-70. DMP6SC2 RU http://www.ncbi.nlm.nih.gov/pubmed/12065434 DMAP8MV DI DMAP8MV DMAP8MV DN Iron DMAP8MV MI DEXVHDB DMAP8MV MN Friedreich ataxia protein (FXN) DMAP8MV MT DME DMAP8MV MA Metabolism DMAP8MV RN Iron dysregulation in Friedreich ataxia. Semin Pediatr Neurol. 2006 Sep;13(3):166-75. DMAP8MV RU https://www.ncbi.nlm.nih.gov/pubmed/?term=17101455 DMAP8MV DI DMAP8MV DMAP8MV DN Iron DMAP8MV MI TTQO71U DMAP8MV MN Hemoglobin (HB) DMAP8MV MT DTT DMAP8MV MA Activator DMAP8MV RN Efficacy and safety of total dose infusion of low molecular weight iron dextran in the treatment of iron deficiency anemia during pregnancy. J Coll Physicians Surg Pak. 2008 Jul;18(7):424-7. DMAP8MV RU https://pubmed.ncbi.nlm.nih.gov/18760066 DMAP8MV DI DMAP8MV DMAP8MV DN Iron DMAP8MV MI DTVKMHD DMAP8MV MN Natural resistance-associated macrophage protein 2 (SLC11A2) DMAP8MV MT DTP DMAP8MV MA Substrate DMAP8MV RN Transmembrane topology of the mammalian Slc11a2 iron transporter. Biochemistry. 2009 Sep 8;48(35):8422-34. DMAP8MV RU http://www.ncbi.nlm.nih.gov/pubmed/19621945 DMAP8MV DI DMAP8MV DMAP8MV DN Iron DMAP8MV MI DTG1RJO DMAP8MV MN Sodium/bile acid cotransporter 7 (SLC10A7) DMAP8MV MT DTP DMAP8MV MA Substrate DMAP8MV RN Modulation of macrophage iron transport by Nramp1 (Slc11a1). Immunobiology. 2007;212(9-10):751-7. DMAP8MV RU http://www.ncbi.nlm.nih.gov/pubmed/18086376 DM5OY70 DI DM5OY70 DM5OY70 DN Iron Dextran DM5OY70 MI TTQO71U DM5OY70 MN Hemoglobin (HB) DM5OY70 MT DTT DM5OY70 MA Activator DM5OY70 RN Efficacy and safety of total dose infusion of low molecular weight iron dextran in the treatment of iron deficiency anemia during pregnancy. J Coll Physicians Surg Pak. 2008 Jul;18(7):424-7. DM5OY70 RU https://pubmed.ncbi.nlm.nih.gov/18760066 DMD45S9 DI DMD45S9 DMD45S9 DN Isavuconazonium DMD45S9 MI DE4LYSA DMD45S9 MN Cytochrome P450 3A4 (CYP3A4) DMD45S9 MT DME DMD45S9 MA Metabolism DMD45S9 RN Isavuconazole: pharmacology, pharmacodynamics, and current clinical experience with a new triazole antifungal agent. Pharmacotherapy. 2015 Nov;35(11):1037-51. DMD45S9 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=26598096 DMJ9G23 DI DMJ9G23 DMJ9G23 DN ISIS 1570 DMJ9G23 MI TTA1L39 DMJ9G23 MN ICAM1 messenger RNA (ICAM1 mRNA) DMJ9G23 MT DTT DMJ9G23 RN US patent application no. 6,300,491, Oligonucleotide inhibition of cell adhesion. DMJ9G23 RU http://www.patentbuddy.com/Patent/6300491?ft=true&sr=true DMAF1NB DI DMAF1NB DMAF1NB DN Isocarboxazid DMAF1NB MI TT3WG5C DMAF1NB MN Monoamine oxidase type A (MAO-A) DMAF1NB MT DTT DMAF1NB MA Inhibitor DMAF1NB RN MAOIs in the contemporary treatment of depression. Neuropsychopharmacology. 1995 May;12(3):185-219. DMAF1NB RU https://pubmed.ncbi.nlm.nih.gov/7612154 DMITSEH DI DMITSEH DMITSEH DN Isoetharine DMITSEH MI TT2CJVK DMITSEH MN Adrenergic receptor beta-2 (ADRB2) DMITSEH MT DTT DMITSEH MA Modulator DMITSEH RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. DMITSEH RU https://www.fda.gov/ DMY6T31 DI DMY6T31 DMY6T31 DN Isoflurane DMY6T31 MI DEPKLMQ DMY6T31 MN Cytochrome P450 2B6 (CYP2B6) DMY6T31 MT DME DMY6T31 MA Metabolism DMY6T31 RN Summary of information on human CYP enzymes: human P450 metabolism data. Drug Metab Rev. 2002 Feb-May;34(1-2):83-448. DMY6T31 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=11996015 DMY6T31 DI DMY6T31 DMY6T31 DN Isoflurane DMY6T31 MI DEVDYN7 DMY6T31 MN Cytochrome P450 2E1 (CYP2E1) DMY6T31 MT DME DMY6T31 MA Metabolism DMY6T31 RN Clinical isoflurane metabolism by cytochrome P450 2E1. Anesthesiology. 1999 Mar;90(3):766-71. DMY6T31 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=10078678 DMY6T31 DI DMY6T31 DMY6T31 DN Isoflurane DMY6T31 MI TTAN6JD DMY6T31 MN Glutamate receptor AMPA (GRIA) DMY6T31 MT DTT DMY6T31 MA Agonist DMY6T31 RN Transmembrane residues define the action of isoflurane at the GABAA receptor alpha-3 subunit. Brain Res. 2005 Jan 25;1032(1-2):30-5. DMY6T31 RU https://pubmed.ncbi.nlm.nih.gov/15680938 DMBSK7X DI DMBSK7X DMBSK7X DN Isoflurophate DMBSK7X MI TT1RS9F DMBSK7X MN Acetylcholinesterase (AChE) DMBSK7X MT DTT DMBSK7X MA Inhibitor DMBSK7X RN Rational design of alkylene-linked bis-pyridiniumaldoximes as improved acetylcholinesterase reactivators. Chem Biol. 2003 Jun;10(6):491-502. DMBSK7X RU https://pubmed.ncbi.nlm.nih.gov/12837382 DM5JVS3 DI DM5JVS3 DM5JVS3 DN Isoniazid DM5JVS3 MI DEXCQTM DM5JVS3 MN Arylamine N-acetyltransferase (NAT) DM5JVS3 MT DME DM5JVS3 MA Metabolism DM5JVS3 RN The actinobacterium Tsukamurella paurometabola has a functionally divergent arylamine N-acetyltransferase (NAT) homolog. World J Microbiol Biotechnol. 2019 Oct 31;35(11):174. DM5JVS3 RU https://pubmed.ncbi.nlm.nih.gov/31673919 DM5JVS3 DI DM5JVS3 DM5JVS3 DN Isoniazid DM5JVS3 MI TTVTX4N DM5JVS3 MN Bacterial Fatty acid synthetase I (Bact inhA) DM5JVS3 MT DTT DM5JVS3 MA Inhibitor DM5JVS3 RN Diversity in enoyl-acyl carrier protein reductases. Cell Mol Life Sci. 2009 May;66(9):1507-17. DM5JVS3 RU https://pubmed.ncbi.nlm.nih.gov/19151923 DM5JVS3 DI DM5JVS3 DM5JVS3 DN Isoniazid DM5JVS3 MI DEAGY5M DM5JVS3 MN Catalase-peroxidase (katG) DM5JVS3 MT DME DM5JVS3 MA Metabolism DM5JVS3 RN Crystal structure of the catalase-peroxidase KatG W78F mutant from Synechococcus elongatus PCC7942 in complex with the antitubercular pro-drug isoniazid. FEBS Lett. 2015 Jan 2;589(1):131-7. DM5JVS3 RU https://pubmed.ncbi.nlm.nih.gov/25479089 DM5JVS3 DI DM5JVS3 DM5JVS3 DN Isoniazid DM5JVS3 MI DEVDYN7 DM5JVS3 MN Cytochrome P450 2E1 (CYP2E1) DM5JVS3 MT DME DM5JVS3 MA Metabolism DM5JVS3 RN Inhibition of CYP2E1 catalytic activity in vitro by S-adenosyl-L-methionine. Biochem Pharmacol. 2005 Apr 1;69(7):1081-93. DM5JVS3 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=15763544 DMQYV60 DI DMQYV60 DMQYV60 DN Isopropamide iodide DMQYV60 MI TTOXS3C DMQYV60 MN Muscarinic acetylcholine receptor (CHRM) DMQYV60 MT DTT DMQYV60 MA Modulator DMQYV60 RN Competitive and non-competitive antagonism exhibited by 'selective' antagonists at atrial and ileal muscarinic receptor subtypes. Br J Pharmacol. 1987 Apr;90(4):701-7. DMQYV60 RU https://pubmed.ncbi.nlm.nih.gov/3580704 DMK7MEY DI DMK7MEY DMK7MEY DN Isoproterenol DMK7MEY MI TTR6W5O DMK7MEY MN Adrenergic receptor beta-1 (ADRB1) DMK7MEY MT DTT DMK7MEY MA Agonist DMK7MEY RN Current therapeutic uses and potential of beta-adrenoceptor agonists and antagonists. Eur J Clin Pharmacol. 1998 Feb;53(6):389-404. DMK7MEY RU https://pubmed.ncbi.nlm.nih.gov/9551698 DMK7MEY DI DMK7MEY DMK7MEY DN Isoproterenol DMK7MEY MI TT2CJVK DMK7MEY MN Adrenergic receptor beta-2 (ADRB2) DMK7MEY MT DTT DMK7MEY MA Modulator DMK7MEY RN Current therapeutic uses and potential of beta-adrenoceptor agonists and antagonists. Eur J Clin Pharmacol. 1998 Feb;53(6):389-404. DMK7MEY RU https://pubmed.ncbi.nlm.nih.gov/9551698 DMK7MEY DI DMK7MEY DMK7MEY DN Isoproterenol DMK7MEY MI TTGW72V DMK7MEY MN Interleukin-12 beta (IL12B) DMK7MEY MT DTT DMK7MEY MA Modulator DMK7MEY RN A phase 1 study of AS1409, a novel antibody-cytokine fusion protein, in patients with malignant melanoma or renal cell carcinoma. Clin Cancer Res. 2011 Apr 1;17(7):1998-2005. DMK7MEY RU https://pubmed.ncbi.nlm.nih.gov/21447719 DMK7MEY DI DMK7MEY DMK7MEY DN Isoproterenol DMK7MEY MI DEFQ8VO DMK7MEY MN Thiopurine methyltransferase (TPMT) DMK7MEY MT DME DMK7MEY MA Metabolism DMK7MEY RN Identification, characterization, and ontogenic study of a catechol O-methyltransferase from zebrafish. Aquat Toxicol. 2011 Mar;102(1-2):18-23. DMK7MEY RU https://www.ncbi.nlm.nih.gov/pubmed/?term=21371608 DMBI4JG DI DMBI4JG DMBI4JG DN Isosorbide dinitrate DMBI4JG MI DE4LYSA DMBI4JG MN Cytochrome P450 3A4 (CYP3A4) DMBI4JG MT DME DMBI4JG MA Metabolism DMBI4JG RN Isoforms of cytochrome P450 on organic nitrate-derived nitric oxide release in human heart vessels. FEBS Lett. 1999 Jun 11;452(3):165-9. DMBI4JG RU https://www.ncbi.nlm.nih.gov/pubmed/?term=10386583 DMBI4JG DI DMBI4JG DMBI4JG DN Isosorbide dinitrate DMBI4JG MI DE4ZHS1 DMBI4JG MN Glutathione S-transferase alpha-1 (GSTA1) DMBI4JG MT DME DMBI4JG MA Metabolism DMBI4JG RN Nitroglycerin and isosorbide dinitrate stimulation of glutathione disulfide efflux from perfused rat liver. Biochem Pharmacol. 1989 Nov 1;38(21):3807-10. DMBI4JG RU https://www.ncbi.nlm.nih.gov/pubmed/?term=2512927 DMBI4JG DI DMBI4JG DMBI4JG DN Isosorbide dinitrate DMBI4JG MI TT6HPVC DMBI4JG MN Guanylate cyclase (GC) DMBI4JG MT DTT DMBI4JG MA Stimulator DMBI4JG RN Nitric oxide and nitric oxide synthase isoforms in the normal, hypertrophic, and failing heart. Mol Cell Biochem. 2010 Jan;333(1-2):191-201. DMBI4JG RU https://pubmed.ncbi.nlm.nih.gov/19618122 DMYLMU0 DI DMYLMU0 DMYLMU0 DN Isosorbide mononitrate DMYLMU0 MI DE4LYSA DMYLMU0 MN Cytochrome P450 3A4 (CYP3A4) DMYLMU0 MT DME DMYLMU0 MA Metabolism DMYLMU0 RN Isoforms of cytochrome P450 on organic nitrate-derived nitric oxide release in human heart vessels. FEBS Lett. 1999 Jun 11;452(3):165-9. DMYLMU0 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=10386583 DMYLMU0 DI DMYLMU0 DMYLMU0 DN Isosorbide mononitrate DMYLMU0 MI TT6HPVC DMYLMU0 MN Guanylate cyclase (GC) DMYLMU0 MT DTT DMYLMU0 MA Stimulator DMYLMU0 RN Nitric oxide and nitric oxide synthase isoforms in the normal, hypertrophic, and failing heart. Mol Cell Biochem. 2010 Jan;333(1-2):191-201. DMYLMU0 RU https://pubmed.ncbi.nlm.nih.gov/19618122 DM4QTBN DI DM4QTBN DM4QTBN DN Isotretinoin DM4QTBN MI DE4LYSA DM4QTBN MN Cytochrome P450 3A4 (CYP3A4) DM4QTBN MT DME DM4QTBN MA Metabolism DM4QTBN RN The effect of isotretinoin on the pharmacokinetics and pharmacodynamics of ethinyl estradiol and norethindrone. Clin Pharmacol Ther. 2004 May;75(5):464-75. DM4QTBN RU https://www.ncbi.nlm.nih.gov/pubmed/?term=15116059 DM4QTBN DI DM4QTBN DM4QTBN DN Isotretinoin DM4QTBN MI TTOD7B3 DM4QTBN MN Retinoic acid receptor (RAR) DM4QTBN MT DTT DM4QTBN MA Agonist DM4QTBN RN Retinoid agonist isotretinoin ameliorates obstructive renal injury. J Urol. 2003 Oct;170(4 Pt 1):1398-402. DM4QTBN RU https://pubmed.ncbi.nlm.nih.gov/14501777 DMX7LKS DI DMX7LKS DMX7LKS DN Isovanillin DMX7LKS MI TT3MOS2 DMX7LKS MN Aldehyde oxidase (AOX1) DMX7LKS MT DTT DMX7LKS MA Inhibitor DMX7LKS RN Contribution of aldehyde oxidizing enzymes on the metabolism of 3,4-dimethoxy-2-phenylethylamine to 3,4-dimethoxyphenylacetic acid by guinea pig li... Cell Physiol Biochem. 2006;17(1-2):47-56. DMX7LKS RU https://pubmed.ncbi.nlm.nih.gov/16543721 DMJL10P DI DMJL10P DMJL10P DN Isoxyl DMJL10P MI TT6RIOV DMJL10P MN Acyl-CoA desaturase (SCD) DMJL10P MT DTT DMJL10P MA Binder DMJL10P RN Has nature already identified all useful antibacterial targets Curr Opin Microbiol. 2008 Oct;11(5):387-92. DMJL10P RU https://pubmed.ncbi.nlm.nih.gov/18804175 DMWCRN1 DI DMWCRN1 DMWCRN1 DN Ispaghula DMWCRN1 MI TTH18TF DMWCRN1 MN Muscarinic acetylcholine receptor M5 (CHRM5) DMWCRN1 MT DTT DMWCRN1 MA Antagonist DMWCRN1 RN Emerging drugs for irritable bowel syndrome. Expert Opin Emerg Drugs. 2006 May;11(2):293-313. DMWCRN1 RU https://pubmed.ncbi.nlm.nih.gov/16634703 DMA5XGH DI DMA5XGH DMA5XGH DN Isradipine DMA5XGH MI TT5HONZ DMA5XGH MN Calcium channel unspecific (CaC) DMA5XGH MT DTT DMA5XGH MA Modulator DMA5XGH RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. DMA5XGH RU https://www.fda.gov/ DM20VSK DI DM20VSK DM20VSK DN Istradefylline DM20VSK MI TTM2AOE DM20VSK MN Adenosine A2a receptor (ADORA2A) DM20VSK MT DTT DM20VSK MA Modulator DM20VSK RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health Human Services. 2019 DM20VSK RU https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/022075s000lbl.pdf DM20VSK DI DM20VSK DM20VSK DN Istradefylline DM20VSK MI DEJGDUW DM20VSK MN Cytochrome P450 1A2 (CYP1A2) DM20VSK MT DME DM20VSK MA Metabolism DM20VSK RN Effects of rifampin on the pharmacokinetics of a single dose of istradefylline in healthy subjects. J Clin Pharmacol. 2018 Feb;58(2):193-201. DM20VSK RU https://www.ncbi.nlm.nih.gov/pubmed/?term=28881378 DM20VSK DI DM20VSK DM20VSK DN Istradefylline DM20VSK MI DEPKLMQ DM20VSK MN Cytochrome P450 2B6 (CYP2B6) DM20VSK MT DME DM20VSK MA Metabolism DM20VSK RN Effects of rifampin on the pharmacokinetics of a single dose of istradefylline in healthy subjects. J Clin Pharmacol. 2018 Feb;58(2):193-201. DM20VSK RU https://www.ncbi.nlm.nih.gov/pubmed/?term=28881378 DM20VSK DI DM20VSK DM20VSK DN Istradefylline DM20VSK MI DEZMWRE DM20VSK MN Cytochrome P450 2C18 (CYP2C18) DM20VSK MT DME DM20VSK MA Metabolism DM20VSK RN Effects of rifampin on the pharmacokinetics of a single dose of istradefylline in healthy subjects. J Clin Pharmacol. 2018 Feb;58(2):193-201. DM20VSK RU https://www.ncbi.nlm.nih.gov/pubmed/?term=28881378 DM20VSK DI DM20VSK DM20VSK DN Istradefylline DM20VSK MI DES5XRU DM20VSK MN Cytochrome P450 2C8 (CYP2C8) DM20VSK MT DME DM20VSK MA Metabolism DM20VSK RN Effects of rifampin on the pharmacokinetics of a single dose of istradefylline in healthy subjects. J Clin Pharmacol. 2018 Feb;58(2):193-201. DM20VSK RU https://www.ncbi.nlm.nih.gov/pubmed/?term=28881378 DM20VSK DI DM20VSK DM20VSK DN Istradefylline DM20VSK MI DE5IED8 DM20VSK MN Cytochrome P450 2C9 (CYP2C9) DM20VSK MT DME DM20VSK MA Metabolism DM20VSK RN Effects of rifampin on the pharmacokinetics of a single dose of istradefylline in healthy subjects. J Clin Pharmacol. 2018 Feb;58(2):193-201. DM20VSK RU https://www.ncbi.nlm.nih.gov/pubmed/?term=28881378 DM20VSK DI DM20VSK DM20VSK DN Istradefylline DM20VSK MI DECB0K3 DM20VSK MN Cytochrome P450 2D6 (CYP2D6) DM20VSK MT DME DM20VSK MA Metabolism DM20VSK RN Effects of rifampin on the pharmacokinetics of a single dose of istradefylline in healthy subjects. J Clin Pharmacol. 2018 Feb;58(2):193-201. DM20VSK RU https://www.ncbi.nlm.nih.gov/pubmed/?term=28881378 DM20VSK DI DM20VSK DM20VSK DN Istradefylline DM20VSK MI DE4LYSA DM20VSK MN Cytochrome P450 3A4 (CYP3A4) DM20VSK MT DME DM20VSK MA Metabolism DM20VSK RN Effects of rifampin on the pharmacokinetics of a single dose of istradefylline in healthy subjects. J Clin Pharmacol. 2018 Feb;58(2):193-201. DM20VSK RU https://www.ncbi.nlm.nih.gov/pubmed/?term=28881378 DM20VSK DI DM20VSK DM20VSK DN Istradefylline DM20VSK MI DEIBDNY DM20VSK MN Cytochrome P450 3A5 (CYP3A5) DM20VSK MT DME DM20VSK MA Metabolism DM20VSK RN Effects of rifampin on the pharmacokinetics of a single dose of istradefylline in healthy subjects. J Clin Pharmacol. 2018 Feb;58(2):193-201. DM20VSK RU https://www.ncbi.nlm.nih.gov/pubmed/?term=28881378 DMCR1MV DI DMCR1MV DMCR1MV DN Itraconazole DMCR1MV MI TTTSOUD DMCR1MV MN Candida Cytochrome P450 51 (Candi ERG11) DMCR1MV MT DTT DMCR1MV MA Modulator DMCR1MV RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. DMCR1MV RU https://www.fda.gov/ DMCR1MV DI DMCR1MV DMCR1MV DN Itraconazole DMCR1MV MI DE4LYSA DMCR1MV MN Cytochrome P450 3A4 (CYP3A4) DMCR1MV MT DME DMCR1MV MA Metabolism DMCR1MV RN Effects of itraconazole and tandospirone on the pharmacokinetics of perospirone. Ther Drug Monit. 2006 Feb;28(1):73-5. DMCR1MV RU https://www.ncbi.nlm.nih.gov/pubmed/?term=16418697 DMCR1MV DI DMCR1MV DMCR1MV DN Itraconazole DMCR1MV MI TT4LXBC DMCR1MV MN Hedgehog signaling pathway (HS pathway) DMCR1MV MT DTT DMCR1MV MA Inhibitor DMCR1MV RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMCR1MV RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DMCR1MV DI DMCR1MV DMCR1MV DN Itraconazole DMCR1MV MI DTUGYRD DMCR1MV MN P-glycoprotein 1 (ABCB1) DMCR1MV MT DTP DMCR1MV MA Substrate DMCR1MV RN Mammalian drug efflux transporters of the ATP binding cassette (ABC) family in multidrug resistance: A review of the past decade. Cancer Lett. 2016 Jan 1;370(1):153-64. DMCR1MV RU http://www.ncbi.nlm.nih.gov/pubmed/26499806 DMCR1MV DI DMCR1MV DMCR1MV DN Itraconazole DMCR1MV MI DEYGVN4 DMCR1MV MN UDP-glucuronosyltransferase 1A1 (UGT1A1) DMCR1MV MT DME DMCR1MV MA Metabolism DMCR1MV RN Investigation into UDP-glucuronosyltransferase (UGT) enzyme kinetics of imidazole- and triazole-containing antifungal drugs in human liver microsomes and recombinant UGT enzymes. Drug Metab Dispos. 2010 Jun;38(6):923-9. DMCR1MV RU https://www.ncbi.nlm.nih.gov/pubmed/?term=20304965 DM0L594 DI DM0L594 DM0L594 DN Ivabradine DM0L594 MI DE4LYSA DM0L594 MN Cytochrome P450 3A4 (CYP3A4) DM0L594 MT DME DM0L594 MA Metabolism DM0L594 RN Ivabradine: new drug. Best avoided in stable angina. Prescrire Int. 2007 Apr;16(88):53-6. DM0L594 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=17458043 DM0L594 DI DM0L594 DM0L594 DN Ivabradine DM0L594 MI TTKLW9S DM0L594 MN Hyperpolarization cyclic nucleotide-gated channel (HCN) DM0L594 MT DTT DM0L594 MA Inhibitor DM0L594 RN Antibodies and venom peptides: new modalities for ion channels. Nat Rev Drug Discov. 2019 May;18(5):339-357. DM0L594 RU https://pubmed.ncbi.nlm.nih.gov/30728472 DM0L594 DI DM0L594 DM0L594 DN Ivabradine DM0L594 MI TTFCQYU DM0L594 MN Sinus node I(f) channel (SA node IfC) DM0L594 MT DTT DM0L594 MA Modulator DM0L594 RN Ivabradine - the first selective sinus node If channel inhibitor in the treatment of stable angina. Int J Clin Pract. 2006 February; 60(2): 222-228. DM0L594 RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1448693/ DMZC1HS DI DMZC1HS DMZC1HS DN Ivacaftor DMZC1HS MI TTRLZHP DMZC1HS MN cAMP-dependent chloride channel (CFTR) DMZC1HS MT DTT DMZC1HS MA Modulator DMZC1HS RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015 DMZC1HS RU https://www.accessdata.fda.gov/scripts/cder/drugsatfda/ DMZC1HS DI DMZC1HS DMZC1HS DN Ivacaftor DMZC1HS MI DE4LYSA DMZC1HS MN Cytochrome P450 3A4 (CYP3A4) DMZC1HS MT DME DMZC1HS MA Metabolism DMZC1HS RN Sensitivity of ivacaftor to drug-drug interactions with rifampin, a cytochrome P450 3A4 inducer. Pediatr Pulmonol. 2018 May;53(5):E6-E8. DMZC1HS RU https://www.ncbi.nlm.nih.gov/pubmed/?term=29488691 DMZC1HS DI DMZC1HS DMZC1HS DN Ivacaftor DMZC1HS MI DEIBDNY DMZC1HS MN Cytochrome P450 3A5 (CYP3A5) DMZC1HS MT DME DMZC1HS MA Metabolism DMZC1HS RN Sensitivity of ivacaftor to drug-drug interactions with rifampin, a cytochrome P450 3A4 inducer. Pediatr Pulmonol. 2018 May;53(5):E6-E8. DMZC1HS RU https://www.ncbi.nlm.nih.gov/pubmed/?term=29488691 DMZC1HS DI DMZC1HS DMZC1HS DN Ivacaftor DMZC1HS MI DTUGYRD DMZC1HS MN P-glycoprotein 1 (ABCB1) DMZC1HS MT DTP DMZC1HS MA Substrate DMZC1HS RN Investigation of the effects of the CFTR potentiator ivacaftor on human P-glycoprotein (ABCB1). Sci Rep. 2017 Dec 13;7(1):17481. DMZC1HS RU http://www.ncbi.nlm.nih.gov/pubmed/29235532 DMDBX5F DI DMDBX5F DMDBX5F DN Ivermectin DMDBX5F MI DE4LYSA DMDBX5F MN Cytochrome P450 3A4 (CYP3A4) DMDBX5F MT DME DMDBX5F MA Metabolism DMDBX5F RN Identification of cytochrome P4503A4 as the major enzyme responsible for the metabolism of ivermectin by human liver microsomes. Xenobiotica. 1998 Mar;28(3):313-21. DMDBX5F RU https://www.ncbi.nlm.nih.gov/pubmed/?term=9574819 DMDBX5F DI DMDBX5F DMDBX5F DN Ivermectin DMDBX5F MI DTSYQGK DMDBX5F MN Multidrug resistance-associated protein 1 (ABCC1) DMDBX5F MT DTP DMDBX5F MA Substrate DMDBX5F RN Interaction of ivermectin with multidrug resistance proteins (MRP1, 2 and 3). Chem Biol Interact. 2006 Feb 25;159(3):169-79. DMDBX5F RU http://www.ncbi.nlm.nih.gov/pubmed/16384552 DMDBX5F DI DMDBX5F DMDBX5F DN Ivermectin DMDBX5F MI TTSNVHO DMDBX5F MN Onchocerca Glutamate-gated chloride channel (Onchoc GluCl) DMDBX5F MT DTT DMDBX5F MA Activator DMDBX5F RN Inhibitory neurotransmission and olfactory memory in honeybees. Neurobiol Learn Mem. 2008 Nov;90(4):589-95. DMDBX5F RU https://pubmed.ncbi.nlm.nih.gov/18755283 DMDBX5F DI DMDBX5F DMDBX5F DN Ivermectin DMDBX5F MI DTUGYRD DMDBX5F MN P-glycoprotein 1 (ABCB1) DMDBX5F MT DTP DMDBX5F MA Substrate DMDBX5F RN MDR1-deficient genotype in Collie dogs hypersensitive to the P-glycoprotein substrate ivermectin. Eur J Pharmacol. 2003 Jan 24;460(2-3):85-91. DMDBX5F RU http://www.ncbi.nlm.nih.gov/pubmed/12559367 DM8S6T7 DI DM8S6T7 DM8S6T7 DN Ivosidenib DM8S6T7 MI TTV2A1R DM8S6T7 MN Oxalosuccinate decarboxylase (IDH1) DM8S6T7 MT DTT DM8S6T7 MA Inhibitor DM8S6T7 RN 2018 FDA drug approvals.Nat Rev Drug Discov. 2019 Feb;18(2):85-89. DM8S6T7 RU https://pubmed.ncbi.nlm.nih.gov/30710142 DMRVITQ DI DMRVITQ DMRVITQ DN Ivosidenib DMRVITQ MI DTUGYRD DMRVITQ MN P-glycoprotein 1 (ABCB1) DMRVITQ MT DTP DMRVITQ MA Substrate DMRVITQ RN DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. (ID: DB14568) DMRVITQ RU https://www.drugbank.ca/drugs/DB14568 DM2OZ3G DI DM2OZ3G DM2OZ3G DN Ixabepilone DM2OZ3G MI DE4LYSA DM2OZ3G MN Cytochrome P450 3A4 (CYP3A4) DM2OZ3G MT DME DM2OZ3G MA Metabolism DM2OZ3G RN The effect of ketoconazole on the pharmacokinetics and pharmacodynamics of ixabepilone: a first in class epothilone B analogue in late-phase clinical development. Clin Cancer Res. 2008 May 1;14(9):2701-9. DM2OZ3G RU https://www.ncbi.nlm.nih.gov/pubmed/?term=18451235 DM2OZ3G DI DM2OZ3G DM2OZ3G DN Ixabepilone DM2OZ3G MI DTUGYRD DM2OZ3G MN P-glycoprotein 1 (ABCB1) DM2OZ3G MT DTP DM2OZ3G MA Substrate DM2OZ3G RN Ixabepilone, a novel microtubule-targeting agent for breast cancer, is a substrate for P-glycoprotein (P-gp/MDR1/ABCB1) but not breast cancer resistance protein (BCRP/ABCG2). J Pharmacol Exp Ther. 2011 May;337(2):423-32. DM2OZ3G RU http://www.ncbi.nlm.nih.gov/pubmed/21262849 DM2OZ3G DI DM2OZ3G DM2OZ3G DN Ixabepilone DM2OZ3G MI TTML2WA DM2OZ3G MN Tubulin (TUB) DM2OZ3G MT DTT DM2OZ3G MA Stablizer DM2OZ3G RN Mullard A: 2010 FDA drug approvals. Nat Rev Drug Discov. 2011 Feb;10(2):82-5. DM2OZ3G RU https://pubmed.ncbi.nlm.nih.gov/21283092 DMXW92T DI DMXW92T DMXW92T DN Ixekizumab DMXW92T MI TTG0MT6 DMXW92T MN Interleukin-17 (IL17) DMXW92T MT DTT DMXW92T MA Modulator DMXW92T RN Brodalumab and ixekizumab, anti-interleukin-17-receptor antibodies for psoriasis: a critical appraisal. Br J Dermatol. 2012 Oct;167(4):710-3; discussion 714-5. DMXW92T RU https://pubmed.ncbi.nlm.nih.gov/23013312 DMKJ8LB DI DMKJ8LB DMKJ8LB DN Josamycin DMKJ8LB MI TTUWYEA DMKJ8LB MN Bacterial 50S ribosomal RNA (Bact 50S rRNA) DMKJ8LB MT DTT DMKJ8LB MA Binder DMKJ8LB RN The mechanism of action of macrolides, lincosamides and streptogramin B reveals the nascent peptide exit path in the ribosome. J Mol Biol. 2003 Jul 25;330(5):1005-14. DMKJ8LB RU https://pubmed.ncbi.nlm.nih.gov/12860123 DMITFB8 DI DMITFB8 DMITFB8 DN Kanamycin DMITFB8 MI DEWPAJD DMITFB8 MN Aminoglycoside O-phosphotransferase (aphA6) DMITFB8 MT DME DMITFB8 MA Metabolism DMITFB8 RN Relationship between antimicrobial resistance and aminoglycoside-modifying enzyme gene expressions in Acinetobacter baumannii. Chin Med J (Engl). 2005 Jan 20;118(2):141-5. DMITFB8 RU https://pubmed.ncbi.nlm.nih.gov/15667800 DMITFB8 DI DMITFB8 DMITFB8 DN Kanamycin DMITFB8 MI DE5WGIM DMITFB8 MN Aminoglycoside phosphotransferase (aph-Ib) DMITFB8 MT DME DMITFB8 MA Metabolism DMITFB8 RN Cloning and expression of novel aminoglycoside phosphotransferase genes from Campylobacter and their role in the resistance to six aminoglycosides. Antimicrob Agents Chemother. 2017 Dec 21;62(1). pii: e01682-17. DMITFB8 RU https://pubmed.ncbi.nlm.nih.gov/29109167 DMITFB8 DI DMITFB8 DMITFB8 DN Kanamycin DMITFB8 MI DE2M583 DMITFB8 MN Endoglucanase Y (EGY) DMITFB8 MT DME DMITFB8 MA Metabolism DMITFB8 RN Expression of Clostridium thermocellum endoglucanase gene in Lactobacillus gasseri and Lactobacillus johnsonii and characterization of the genetically modified probiotic lactobacilli. Curr Microbiol. 2000 Apr;40(4):257-63. DMITFB8 RU https://pubmed.ncbi.nlm.nih.gov/10688695 DMITFB8 DI DMITFB8 DMITFB8 DN Kanamycin DMITFB8 MI DE2AZTG DMITFB8 MN Endoglucanase Y (EGY) DMITFB8 MT DME DMITFB8 MA Metabolism DMITFB8 RN Expression of Clostridium thermocellum endoglucanase gene in Lactobacillus gasseri and Lactobacillus johnsonii and characterization of the genetically modified probiotic lactobacilli. Curr Microbiol. 2000 Apr;40(4):257-63. DMITFB8 RU https://pubmed.ncbi.nlm.nih.gov/10688695 DMITFB8 DI DMITFB8 DMITFB8 DN Kanamycin DMITFB8 MI DECXWN8 DMITFB8 MN Kanamycin/gentamycin-resistance enzyme (aacA) DMITFB8 MT DME DMITFB8 MA Metabolism DMITFB8 RN Cloning and expression of novel aminoglycoside phosphotransferase genes from Campylobacter and their role in the resistance to six aminoglycosides. Antimicrob Agents Chemother. 2017 Dec 21;62(1). pii: e01682-17. DMITFB8 RU https://pubmed.ncbi.nlm.nih.gov/29109167 DM2DMPO DI DM2DMPO DM2DMPO DN Kanamycin DM2DMPO MI TTQ8KVI DM2DMPO MN Staphylococcus 30S ribosomal subunit (Stap-coc pbp2) DM2DMPO MT DTT DM2DMPO MA Binder DM2DMPO RN SsrA-mediated protein tagging in the presence of miscoding drugs and its physiological role in Escherichia coli. Genes Cells. 2002 Jul;7(7):629-38. DM2DMPO RU https://pubmed.ncbi.nlm.nih.gov/12081641 DMT5HA4 DI DMT5HA4 DMT5HA4 DN Ketamine DMT5HA4 MI DEPKLMQ DMT5HA4 MN Cytochrome P450 2B6 (CYP2B6) DMT5HA4 MT DME DMT5HA4 MA Metabolism DMT5HA4 RN Contribution of CYP3A4, CYP2B6, and CYP2C9 isoforms to N-demethylation of ketamine in human liver microsomes. Drug Metab Dispos. 2002 Jul;30(7):853-8. DMT5HA4 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=12065445 DMT5HA4 DI DMT5HA4 DMT5HA4 DN Ketamine DMT5HA4 MI DE5IED8 DMT5HA4 MN Cytochrome P450 2C9 (CYP2C9) DMT5HA4 MT DME DMT5HA4 MA Metabolism DMT5HA4 RN Contribution of CYP3A4, CYP2B6, and CYP2C9 isoforms to N-demethylation of ketamine in human liver microsomes. Drug Metab Dispos. 2002 Jul;30(7):853-8. DMT5HA4 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=12065445 DMT5HA4 DI DMT5HA4 DMT5HA4 DN Ketamine DMT5HA4 MI DE4LYSA DMT5HA4 MN Cytochrome P450 3A4 (CYP3A4) DMT5HA4 MT DME DMT5HA4 MA Metabolism DMT5HA4 RN Contribution of CYP3A4, CYP2B6, and CYP2C9 isoforms to N-demethylation of ketamine in human liver microsomes. Drug Metab Dispos. 2002 Jul;30(7):853-8. DMT5HA4 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=12065445 DMT5HA4 DI DMT5HA4 DMT5HA4 DN Ketamine DMT5HA4 MI TT9IK2Z DMT5HA4 MN N-methyl-D-aspartate receptor (NMDAR) DMT5HA4 MT DTT DMT5HA4 MA Antagonist DMT5HA4 RN Ketamine modulates theta and gamma oscillations. J Cogn Neurosci. 2010 Jul;22(7):1452-64. DMT5HA4 RU https://pubmed.ncbi.nlm.nih.gov/19583475 DMVLMW6 DI DMVLMW6 DMVLMW6 DN Ketanserin DMVLMW6 MI TTYSN63 DMVLMW6 MN 5-HT 2 receptor (5HT2R) DMVLMW6 MT DTT DMVLMW6 MA Antagonist DMVLMW6 RN Nordexfenfluramine causes more severe pulmonary vasoconstriction than dexfenfluramine. Am J Physiol Lung Cell Mol Physiol. 2004 Mar;286(3):L531-8. DMVLMW6 RU https://pubmed.ncbi.nlm.nih.gov/14607779 DMM3L6Z DI DMM3L6Z DMM3L6Z DN Ketobemidone DMM3L6Z MI DEPKLMQ DMM3L6Z MN Cytochrome P450 2B6 (CYP2B6) DMM3L6Z MT DME DMM3L6Z MA Metabolism DMM3L6Z RN Ketobemidone is a substrate for cytochrome P4502C9 and 3A4, but not for P-glycoprotein. Xenobiotica. 2005 Aug;35(8):785-96. DMM3L6Z RU https://www.ncbi.nlm.nih.gov/pubmed/?term=16278191 DMM3L6Z DI DMM3L6Z DMM3L6Z DN Ketobemidone DMM3L6Z MI DES5XRU DMM3L6Z MN Cytochrome P450 2C8 (CYP2C8) DMM3L6Z MT DME DMM3L6Z MA Metabolism DMM3L6Z RN Ketobemidone is a substrate for cytochrome P4502C9 and 3A4, but not for P-glycoprotein. Xenobiotica. 2005 Aug;35(8):785-96. DMM3L6Z RU https://www.ncbi.nlm.nih.gov/pubmed/?term=16278191 DMM3L6Z DI DMM3L6Z DMM3L6Z DN Ketobemidone DMM3L6Z MI DE5IED8 DMM3L6Z MN Cytochrome P450 2C9 (CYP2C9) DMM3L6Z MT DME DMM3L6Z MA Metabolism DMM3L6Z RN Ketobemidone is a substrate for cytochrome P4502C9 and 3A4, but not for P-glycoprotein. Xenobiotica. 2005 Aug;35(8):785-96. DMM3L6Z RU https://www.ncbi.nlm.nih.gov/pubmed/?term=16278191 DMM3L6Z DI DMM3L6Z DMM3L6Z DN Ketobemidone DMM3L6Z MI DE4LYSA DMM3L6Z MN Cytochrome P450 3A4 (CYP3A4) DMM3L6Z MT DME DMM3L6Z MA Metabolism DMM3L6Z RN Ketobemidone is a substrate for cytochrome P4502C9 and 3A4, but not for P-glycoprotein. Xenobiotica. 2005 Aug;35(8):785-96. DMM3L6Z RU https://www.ncbi.nlm.nih.gov/pubmed/?term=16278191 DMM3L6Z DI DMM3L6Z DMM3L6Z DN Ketobemidone DMM3L6Z MI DEGTFWK DMM3L6Z MN Mephenytoin 4-hydroxylase (CYP2C19) DMM3L6Z MT DME DMM3L6Z MA Metabolism DMM3L6Z RN Ketobemidone is a substrate for cytochrome P4502C9 and 3A4, but not for P-glycoprotein. Xenobiotica. 2005 Aug;35(8):785-96. DMM3L6Z RU https://www.ncbi.nlm.nih.gov/pubmed/?term=16278191 DMM3L6Z DI DMM3L6Z DMM3L6Z DN Ketobemidone DMM3L6Z MI TTN4QDT DMM3L6Z MN Opioid receptor (OPR) DMM3L6Z MT DTT DMM3L6Z MA Modulator DMM3L6Z RN The mu1 and mu2 opioid receptor binding of ketobemidone, norketobemidone and 3-dimethylamino-1,1-diphenylbutene. Pharmacol Toxicol. 1996 Aug;79(2):103-4. DMM3L6Z RU https://pubmed.ncbi.nlm.nih.gov/8878254 DMM3L6Z DI DMM3L6Z DMM3L6Z DN Ketobemidone DMM3L6Z MI DE073H6 DMM3L6Z MN Prostaglandin G/H synthase 1 (COX-1) DMM3L6Z MT DME DMM3L6Z MA Metabolism DMM3L6Z RN Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. DMM3L6Z RU https://www.ncbi.nlm.nih.gov/pubmed/?term=19515014 DMM3L6Z DI DMM3L6Z DMM3L6Z DN Ketobemidone DMM3L6Z MI DE85D2P DMM3L6Z MN UDP-glucuronosyltransferase 1A9 (UGT1A9) DMM3L6Z MT DME DMM3L6Z MA Metabolism DMM3L6Z RN Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. DMM3L6Z RU https://www.ncbi.nlm.nih.gov/pubmed/?term=19515014 DMPZI3Q DI DMPZI3Q DMPZI3Q DN Ketoconazole DMPZI3Q MI TTTSOUD DMPZI3Q MN Candida Cytochrome P450 51 (Candi ERG11) DMPZI3Q MT DTT DMPZI3Q MA Inhibitor DMPZI3Q RN Clinical pharmacokinetics and pharmacodynamics of solifenacin. Clin Pharmacokinet. 2009;48(5):281-302. DMPZI3Q RU https://pubmed.ncbi.nlm.nih.gov/19566112 DMPZI3Q DI DMPZI3Q DMPZI3Q DN Ketoconazole DMPZI3Q MI DE4LYSA DMPZI3Q MN Cytochrome P450 3A4 (CYP3A4) DMPZI3Q MT DME DMPZI3Q MA Metabolism DMPZI3Q RN The metabolism of amiodarone by various CYP isoenzymes of human and rat, and the inhibitory influence of ketoconazole. J Pharm Pharm Sci. 2008;11(1):147-59. DMPZI3Q RU https://www.ncbi.nlm.nih.gov/pubmed/?term=18445370 DMPZI3Q DI DMPZI3Q DMPZI3Q DN Ketoconazole DMPZI3Q MI DTUGYRD DMPZI3Q MN P-glycoprotein 1 (ABCB1) DMPZI3Q MT DTP DMPZI3Q MA Substrate DMPZI3Q RN Mammalian drug efflux transporters of the ATP binding cassette (ABC) family in multidrug resistance: A review of the past decade. Cancer Lett. 2016 Jan 1;370(1):153-64. DMPZI3Q RU http://www.ncbi.nlm.nih.gov/pubmed/26499806 DMRKXPT DI DMRKXPT DMRKXPT DN Ketoprofen DMRKXPT MI DE5IED8 DMRKXPT MN Cytochrome P450 2C9 (CYP2C9) DMRKXPT MT DME DMRKXPT MA Metabolism DMRKXPT RN Clinical pharmacokinetics of ketoprofen enantiomers in wild type of Cyp 2c8 and Cyp 2c9 patients with rheumatoid arthritis. Eur J Drug Metab Pharmacokinet. 2011 Sep;36(3):167-73. DMRKXPT RU https://www.ncbi.nlm.nih.gov/pubmed/?term=21516380 DMRKXPT DI DMRKXPT DMRKXPT DN Ketoprofen DMRKXPT MI TTVKILB DMRKXPT MN Prostaglandin G/H synthase 2 (COX-2) DMRKXPT MT DTT DMRKXPT MA Inhibitor DMRKXPT RN Probing the skin permeation of fish oil/EPA and ketoprofen-3. Effects on epidermal COX-2 and LOX. Prostaglandins Leukot Essent Fatty Acids. 2007 Jun;76(6):357-62. DMRKXPT RU https://pubmed.ncbi.nlm.nih.gov/17588732 DMRKXPT DI DMRKXPT DMRKXPT DN Ketoprofen DMRKXPT MI DEYGVN4 DMRKXPT MN UDP-glucuronosyltransferase 1A1 (UGT1A1) DMRKXPT MT DME DMRKXPT MA Metabolism DMRKXPT RN Association between the UGT1A1*28 allele and hyperbilirubinemia in HIV-positive patients receiving atazanavir: a meta-analysis. Biosci Rep. 2019 May 2;39(5). pii: BSR20182105. DMRKXPT RU https://www.ncbi.nlm.nih.gov/pubmed/30962262 DMI4EL5 DI DMI4EL5 DMI4EL5 DN Ketorolac DMI4EL5 MI DES5XRU DMI4EL5 MN Cytochrome P450 2C8 (CYP2C8) DMI4EL5 MT DME DMI4EL5 MA Metabolism DMI4EL5 RN Body weight, gender and pregnancy affect enantiomer-specific ketorolac pharmacokinetics. Br J Clin Pharmacol. 2017 Sep;83(9):1966-1975. DMI4EL5 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=28429492 DMI4EL5 DI DMI4EL5 DMI4EL5 DN Ketorolac DMI4EL5 MI TTK0943 DMI4EL5 MN Prostaglandin G/H synthase (COX) DMI4EL5 MT DTT DMI4EL5 MA Inhibitor DMI4EL5 RN Cyclooxygenase and nitric oxide synthase dependence of cutaneous reactive hyperemia in humans. Am J Physiol Heart Circ Physiol. 2007 Jul;293(1):H425-32. DMI4EL5 RU https://pubmed.ncbi.nlm.nih.gov/17369458 DMI4EL5 DI DMI4EL5 DMI4EL5 DN Ketorolac DMI4EL5 MI DEB3CV1 DMI4EL5 MN UDP-glucuronosyltransferase 2B7 (UGT2B7) DMI4EL5 MT DME DMI4EL5 MA Metabolism DMI4EL5 RN Body weight, gender and pregnancy affect enantiomer-specific ketorolac pharmacokinetics. Br J Clin Pharmacol. 2017 Sep;83(9):1966-1975. DMI4EL5 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=28429492 DMOVY05 DI DMOVY05 DMOVY05 DN Ketotifen DMOVY05 MI TTTIBOJ DMOVY05 MN Histamine H1 receptor (H1R) DMOVY05 MT DTT DMOVY05 MA Antagonist DMOVY05 RN Intact cell binding for in vitro prediction of sedative and non-sedative histamine H1-receptor antagonists based on receptor internalization. J Pharmacol Sci. 2008 May;107(1):66-79. DMOVY05 RU https://pubmed.ncbi.nlm.nih.gov/18446005 DM74XKS DI DM74XKS DM74XKS DN Ketotifen DM74XKS MI DE1LZID DM74XKS MN Short-chain dehydrogenase/reductase SDR19C1 (DHRS1) DM74XKS MT DME DM74XKS MA Metabolism DM74XKS RN Initial characterization of human DHRS1 (SDR19C1), a member of the short-chain dehydrogenase/reductase superfamily. J Steroid Biochem Mol Biol. 2019 Jan;185:80-89. DM74XKS RU https://pubmed.ncbi.nlm.nih.gov/30031147 DM0KAE6 DI DM0KAE6 DM0KAE6 DN Kombiglyze XR/Komboglyze FDC DM0KAE6 MI TTDIGC1 DM0KAE6 MN Dipeptidyl peptidase 4 (DPP-4) DM0KAE6 MT DTT DM0KAE6 MA Modulator DM0KAE6 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1612). DM0KAE6 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1612 DMSA4HZ DI DMSA4HZ DMSA4HZ DN KU-0058948 DMSA4HZ MI TTVDSZ0 DMSA4HZ MN Poly [ADP-ribose] polymerase 1 (PARP1) DMSA4HZ MT DTT DMSA4HZ MA Inhibitor DMSA4HZ RN Structural basis for inhibitor specificity in human poly(ADP-ribose) polymerase-3. J Med Chem. 2009 May 14;52(9):3108-11. DMSA4HZ RU https://pubmed.ncbi.nlm.nih.gov/19354255 DMK8U72 DI DMK8U72 DMK8U72 DN Labetalol DMK8U72 MI TTG28O6 DMK8U72 MN Adrenergic receptor Alpha-1 (ADRA1) DMK8U72 MT DTT DMK8U72 MA Antagonist DMK8U72 RN Beta-blockers in the treatment of hypertension: are there clinically relevant differences Postgrad Med. 2009 May;121(3):90-8. DMK8U72 RU https://pubmed.ncbi.nlm.nih.gov/19491545 DMK8U72 DI DMK8U72 DMK8U72 DN Labetalol DMK8U72 MI DECB0K3 DMK8U72 MN Cytochrome P450 2D6 (CYP2D6) DMK8U72 MT DME DMK8U72 MA Metabolism DMK8U72 RN Comparison of verapamil, diltiazem, and labetalol on the bioavailability and metabolism of imipramine. J Clin Pharmacol. 1992 Feb;32(2):176-83. DMK8U72 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=1613128 DMK8U72 DI DMK8U72 DMK8U72 DN Labetalol DMK8U72 MI DEGTFWK DMK8U72 MN Mephenytoin 4-hydroxylase (CYP2C19) DMK8U72 MT DME DMK8U72 MA Metabolism DMK8U72 RN Drug Interactions Flockhart Table DMK8U72 RU https://drug-interactions.medicine.iu.edu/Main-Table.aspx DMK8U72 DI DMK8U72 DMK8U72 DN Labetalol DMK8U72 MI DTE2B1D DMK8U72 MN Organic anion transporting polypeptide 1A2 (SLCO1A2) DMK8U72 MT DTP DMK8U72 MA Substrate DMK8U72 RN Involvement of influx and efflux transport systems in gastrointestinal absorption of celiprolol. J Pharm Sci. 2009 Jul;98(7):2529-39. DMK8U72 RU http://www.ncbi.nlm.nih.gov/pubmed/19067419 DMK8U72 DI DMK8U72 DMK8U72 DN Labetalol DMK8U72 MI DTUGYRD DMK8U72 MN P-glycoprotein 1 (ABCB1) DMK8U72 MT DTP DMK8U72 MA Substrate DMK8U72 RN Human intestinal transporter database: QSAR modeling and virtual profiling of drug uptake, efflux and interactions. Pharm Res. 2013 Apr;30(4):996-1007. DMK8U72 RU https://doi.org/10.1007/s11095-012-0935-x DMK8U72 DI DMK8U72 DMK8U72 DN Labetalol DMK8U72 MI DEYGVN4 DMK8U72 MN UDP-glucuronosyltransferase 1A1 (UGT1A1) DMK8U72 MT DME DMK8U72 MA Metabolism DMK8U72 RN Regulation of UDP-glucuronosyltransferase (UGT) 1A1 by progesterone and its impact on labetalol elimination. Xenobiotica. 2008 Jan;38(1):62-75. DMK8U72 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=18098064 DMK8U72 DI DMK8U72 DMK8U72 DN Labetalol DMK8U72 MI DE85D2P DMK8U72 MN UDP-glucuronosyltransferase 1A9 (UGT1A9) DMK8U72 MT DME DMK8U72 MA Metabolism DMK8U72 RN Regulation of UDP-glucuronosyltransferase (UGT) 1A1 by progesterone and its impact on labetalol elimination. Xenobiotica. 2008 Jan;38(1):62-75. DMK8U72 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=18098064 DMK8U72 DI DMK8U72 DMK8U72 DN Labetalol DMK8U72 MI DENUPDX DMK8U72 MN UDP-glucuronosyltransferase 2B4 (UGT2B4) DMK8U72 MT DME DMK8U72 MA Metabolism DMK8U72 RN Regulation of UDP-glucuronosyltransferase (UGT) 1A1 by progesterone and its impact on labetalol elimination. Xenobiotica. 2008 Jan;38(1):62-75. DMK8U72 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=18098064 DMK8U72 DI DMK8U72 DMK8U72 DN Labetalol DMK8U72 MI DEB3CV1 DMK8U72 MN UDP-glucuronosyltransferase 2B7 (UGT2B7) DMK8U72 MT DME DMK8U72 MA Metabolism DMK8U72 RN Regulation of UDP-glucuronosyltransferase (UGT) 1A1 by progesterone and its impact on labetalol elimination. Xenobiotica. 2008 Jan;38(1):62-75. DMK8U72 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=18098064 DMVM6QR DI DMVM6QR DMVM6QR DN Lacosamide DMVM6QR MI DE5IED8 DMVM6QR MN Cytochrome P450 2C9 (CYP2C9) DMVM6QR MT DME DMVM6QR MA Metabolism DMVM6QR RN Lacosamide: what can be expected from the next new antiepileptic drug? Epilepsy Curr. 2009 Sep-Oct;9(5):133-4. DMVM6QR RU https://www.ncbi.nlm.nih.gov/pubmed/?term=19826503 DMVM6QR DI DMVM6QR DMVM6QR DN Lacosamide DMVM6QR MI TTZCW3T DMVM6QR MN Dihydropyrimidinase related protein 2 (DPYSL2) DMVM6QR MT DTT DMVM6QR MA Modulator DMVM6QR RN 2008 FDA drug approvals. Nat Rev Drug Discov. 2009 Feb;8(2):93-6. DMVM6QR RU https://pubmed.ncbi.nlm.nih.gov/19180096 DMVM6QR DI DMVM6QR DMVM6QR DN Lacosamide DMVM6QR MI DEGTFWK DMVM6QR MN Mephenytoin 4-hydroxylase (CYP2C19) DMVM6QR MT DME DMVM6QR MA Metabolism DMVM6QR RN Lacosamide therapeutic monitoring in patients with epilepsy: effect of concomitant antiepileptic drugs. Ther Drug Monit. 2013 Dec;35(6):849-52. DMVM6QR RU https://www.ncbi.nlm.nih.gov/pubmed/?term=23942540 DMVM6QR DI DMVM6QR DMVM6QR DN Lacosamide DMVM6QR MI TTIG65Q DMVM6QR MN Voltage-gated sodium channel (Nav) DMVM6QR MT DTT DMVM6QR MA Inhibitor DMVM6QR RN Antibodies and venom peptides: new modalities for ion channels. Nat Rev Drug Discov. 2019 May;18(5):339-357. DMVM6QR RU https://pubmed.ncbi.nlm.nih.gov/30728472 DMVM6QR DI DMVM6QR DMVM6QR DN Lacosamide DMVM6QR MI TTN9VTF DMVM6QR MN Voltage-gated sodium channel alpha Nav1.9 (SCN11A) DMVM6QR MT DTT DMVM6QR MA Inhibitor DMVM6QR RN Antibodies and venom peptides: new modalities for ion channels. Nat Rev Drug Discov. 2019 May;18(5):339-357. DMVM6QR RU https://pubmed.ncbi.nlm.nih.gov/30728472 DMA7QTC DI DMA7QTC DMA7QTC DN Lactoferrin DMA7QTC MI TTM1TDX DMA7QTC MN Tryptase alpha/beta-1 (Tryptase) DMA7QTC MT DTT DMA7QTC MA Inhibitor DMA7QTC RN Inhibitors of tryptase for the treatment of mast cell-mediated diseases. Curr Pharm Des. 1998 Oct;4(5):381-96. DMA7QTC RU https://pubmed.ncbi.nlm.nih.gov/10197050 DMV7OPN DI DMV7OPN DMV7OPN DN Lactulose DMV7OPN MI DEIEY19 DMV7OPN MN Beta-galactosidase (bgaB) DMV7OPN MT DME DMV7OPN MA Metabolism DMV7OPN RN In vitro fermentation of lactulose by human gut bacteria. J Agric Food Chem. 2014 Nov 12;62(45):10970-7. DMV7OPN RU https://pubmed.ncbi.nlm.nih.gov/25340538 DMV7OPN DI DMV7OPN DMV7OPN DN Lactulose DMV7OPN MI DE235K6 DMV7OPN MN Beta-glucosidase (bglA) DMV7OPN MT DME DMV7OPN MA Metabolism DMV7OPN RN In vitro fermentation of lactulose by human gut bacteria. J Agric Food Chem. 2014 Nov 12;62(45):10970-7. DMV7OPN RU https://pubmed.ncbi.nlm.nih.gov/25340538 DMV7OPN DI DMV7OPN DMV7OPN DN Lactulose DMV7OPN MI DEPB9C2 DMV7OPN MN Glycosyl hydrolase (glyH) DMV7OPN MT DME DMV7OPN MA Metabolism DMV7OPN RN In vitro fermentation of lactulose by human gut bacteria. J Agric Food Chem. 2014 Nov 12;62(45):10970-7. DMV7OPN RU https://pubmed.ncbi.nlm.nih.gov/25340538 DMZDN4W DI DMZDN4W DMZDN4W DN L-alanine DMZDN4W MI DTC54PX DMZDN4W MN Alanine/serine/cysteine/threonine transporter 1 (SLC1A4) DMZDN4W MT DTP DMZDN4W MA Substrate DMZDN4W RN D-Serine Is a Substrate for Neutral Amino Acid Transporters ASCT1/SLC1A4 and ASCT2/SLC1A5, and Is Transported by Both Subtypes in Rat Hippocampal Astrocyte Cultures. PLoS One. 2016 Jun 7;11(6):e0156551. DMZDN4W RU http://www.ncbi.nlm.nih.gov/pubmed/27272177 DMZDN4W DI DMZDN4W DMZDN4W DN L-alanine DMZDN4W MI TTT2LD9 DMZDN4W MN GABA transaminase (ABAT) DMZDN4W MT DTT DMZDN4W MA Inhibitor DMZDN4W RN DrugBank: a knowledgebase for drugs, drug actions and drug targets. Nucleic Acids Res. 2008 Jan;36(Database issue):D901-6. DMZDN4W RU https://pubmed.ncbi.nlm.nih.gov/18048412 DMZDN4W DI DMZDN4W DMZDN4W DN L-alanine DMZDN4W MI DTJF3DX DMZDN4W MN L-type amino acid transporter 2 (SLC7A8) DMZDN4W MT DTP DMZDN4W MA Substrate DMZDN4W RN The Transporter Classification Database (TCDB): recent advances. Nucleic Acids Res. 2016 Jan 4;44(D1):D372-9. (ID: 2.A.3.8.20) DMZDN4W RU http://www.tcdb.org/search/result.php?tc=2.A.3.8.20 DMZDN4W DI DMZDN4W DMZDN4W DN L-alanine DMZDN4W MI DTD815L DMZDN4W MN Sodium-coupled neutral amino acid transporter 1 (SLC38A1) DMZDN4W MT DTP DMZDN4W MA Substrate DMZDN4W RN Identification of SLC38A7 (SNAT7) protein as a glutamine transporter expressed in neurons. J Biol Chem. 2011 Jun 10;286(23):20500-11. DMZDN4W RU http://www.ncbi.nlm.nih.gov/pubmed/21511949 DMZDN4W DI DMZDN4W DMZDN4W DN L-alanine DMZDN4W MI DTTWL58 DMZDN4W MN Sodium-coupled neutral amino acid transporter 2 (SLC38A2) DMZDN4W MT DTP DMZDN4W MA Substrate DMZDN4W RN Identification of SLC38A7 (SNAT7) protein as a glutamine transporter expressed in neurons. J Biol Chem. 2011 Jun 10;286(23):20500-11. DMZDN4W RU http://www.ncbi.nlm.nih.gov/pubmed/21511949 DMZDN4W DI DMZDN4W DMZDN4W DN L-alanine DMZDN4W MI DTKWJH3 DMZDN4W MN Sodium-coupled neutral amino acid transporter 3 (SLC38A3) DMZDN4W MT DTP DMZDN4W MA Substrate DMZDN4W RN Identification of SLC38A7 (SNAT7) protein as a glutamine transporter expressed in neurons. J Biol Chem. 2011 Jun 10;286(23):20500-11. DMZDN4W RU http://www.ncbi.nlm.nih.gov/pubmed/21511949 DMZDN4W DI DMZDN4W DMZDN4W DN L-alanine DMZDN4W MI DTPJBD5 DMZDN4W MN Sodium-coupled neutral amino acid transporter 4 (SLC38A4) DMZDN4W MT DTP DMZDN4W MA Substrate DMZDN4W RN Identification of SLC38A7 (SNAT7) protein as a glutamine transporter expressed in neurons. J Biol Chem. 2011 Jun 10;286(23):20500-11. DMZDN4W RU http://www.ncbi.nlm.nih.gov/pubmed/21511949 DMZDN4W DI DMZDN4W DMZDN4W DN L-alanine DMZDN4W MI DTLX28N DMZDN4W MN Sodium-coupled neutral amino acid transporter 5 (SLC38A5) DMZDN4W MT DTP DMZDN4W MA Substrate DMZDN4W RN Identification of SLC38A7 (SNAT7) protein as a glutamine transporter expressed in neurons. J Biol Chem. 2011 Jun 10;286(23):20500-11. DMZDN4W RU http://www.ncbi.nlm.nih.gov/pubmed/21511949 DMANBR7 DI DMANBR7 DMANBR7 DN L-alanyl-l-glutamine DMANBR7 MI TTI7S12 DMANBR7 MN Glutamine receptor (GluR) DMANBR7 MT DTT DMANBR7 MA Modulator DMANBR7 RN Natural products as sources of new drugs over the last 25 years. J Nat Prod. 2007 Mar;70(3):461-77. DMANBR7 RU https://pubmed.ncbi.nlm.nih.gov/17309302 DMI347A DI DMI347A DMI347A DN Lamivudine DMI347A MI DTI7UX6 DMI347A MN Breast cancer resistance protein (ABCG2) DMI347A MT DTP DMI347A MA Substrate DMI347A RN The effect of ABCG2 V12M, Q141K and Q126X, known functional variants in vitro, on the disposition of lamivudine. Br J Clin Pharmacol. 2007 Nov;64(5):645-54. DMI347A RU http://www.ncbi.nlm.nih.gov/pubmed/17509035 DMI347A DI DMI347A DMI347A DN Lamivudine DMI347A MI DE4E31Z DMI347A MN Deoxy-5'-nucleotidase 1 (NT5C) DMI347A MT DME DMI347A MA Metabolism DMI347A RN Nucleoside and nucleotide HIV reverse transcriptase inhibitors: 25 years after zidovudine. Antiviral Res. 2010 Jan;85(1):39-58. DMI347A RU https://www.ncbi.nlm.nih.gov/pubmed/?term=19887088 DMI347A DI DMI347A DMI347A DN Lamivudine DMI347A MI TT84ETX DMI347A MN Human immunodeficiency virus Reverse transcriptase (HIV RT) DMI347A MT DTT DMI347A MA Modulator DMI347A RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. DMI347A RU https://www.fda.gov/ DMI347A DI DMI347A DMI347A DN Lamivudine DMI347A MI DTT79CX DMI347A MN Organic cation transporter 1 (SLC22A1) DMI347A MT DTP DMI347A MA Substrate DMI347A RN Relevance of the organic cation transporters 1 and 2 for antiretroviral drug therapy in human immunodeficiency virus infection. Drug Metab Dispos. 2008 Aug;36(8):1616-23. DMI347A RU http://www.ncbi.nlm.nih.gov/pubmed/18490433 DMI347A DI DMI347A DMI347A DN Lamivudine DMI347A MI DT9IDPW DMI347A MN Organic cation transporter 2 (SLC22A2) DMI347A MT DTP DMI347A MA Substrate DMI347A RN Genetic variants of organic cation transporter 1 (OCT1) and OCT2 significantly reduce lamivudine uptake. Biopharm Drug Dispos. 2012 Apr;33(3):170-8. DMI347A RU http://www.ncbi.nlm.nih.gov/pubmed/22415520 DMI347A DI DMI347A DMI347A DN Lamivudine DMI347A MI DEQYXD4 DMI347A MN Phosphorylcholine transferase A (PCYT1A) DMI347A MT DME DMI347A MA Metabolism DMI347A RN Model for intracellular Lamivudine metabolism in peripheral blood mononuclear cells ex vivo and in human immunodeficiency virus type 1-infected adolescents. Antimicrob Agents Chemother. 2006 Aug;50(8):2686-94. DMI347A RU https://www.ncbi.nlm.nih.gov/pubmed/?term=16870759 DMI347A DI DMI347A DMI347A DN Lamivudine DMI347A MI DEIX1PO DMI347A MN Phosphorylethanolamine transferase (PCYT2) DMI347A MT DME DMI347A MA Metabolism DMI347A RN Model for intracellular Lamivudine metabolism in peripheral blood mononuclear cells ex vivo and in human immunodeficiency virus type 1-infected adolescents. Antimicrob Agents Chemother. 2006 Aug;50(8):2686-94. DMI347A RU https://www.ncbi.nlm.nih.gov/pubmed/?term=16870759 DM8SXYG DI DM8SXYG DM8SXYG DN Lamotrigine DM8SXYG MI DTT79CX DM8SXYG MN Organic cation transporter 1 (SLC22A1) DM8SXYG MT DTP DM8SXYG MA Substrate DM8SXYG RN Lamotrigine is a substrate for OCT1 in brain endothelial cells. Biochem Pharmacol. 2012 Mar 15;83(6):805-14. DM8SXYG RU https://doi.org/10.1016/j.bcp.2011.12.032 DM8SXYG DI DM8SXYG DM8SXYG DN Lamotrigine DM8SXYG MI DTUGYRD DM8SXYG MN P-glycoprotein 1 (ABCB1) DM8SXYG MT DTP DM8SXYG MA Substrate DM8SXYG RN Several major antiepileptic drugs are substrates for human P-glycoprotein. Neuropharmacology. 2008 Dec;55(8):1364-75. DM8SXYG RU http://www.ncbi.nlm.nih.gov/pubmed/18824002 DM8SXYG DI DM8SXYG DM8SXYG DN Lamotrigine DM8SXYG MI DEYGVN4 DM8SXYG MN UDP-glucuronosyltransferase 1A1 (UGT1A1) DM8SXYG MT DME DM8SXYG MA Metabolism DM8SXYG RN Drug-drug interactions for UDP-glucuronosyltransferase substrates: a pharmacokinetic explanation for typically observed low exposure (AUCi/AUC) ratios. Drug Metab Dispos. 2004 Nov;32(11):1201-8. DM8SXYG RU https://www.ncbi.nlm.nih.gov/pubmed/?term=15304429 DM8SXYG DI DM8SXYG DM8SXYG DN Lamotrigine DM8SXYG MI DEF2WXN DM8SXYG MN UDP-glucuronosyltransferase 1A3 (UGT1A3) DM8SXYG MT DME DM8SXYG MA Metabolism DM8SXYG RN Variation in glucuronidation of lamotrigine in human liver microsomes. Xenobiotica. 2009 May;39(5):355-63. DM8SXYG RU https://www.ncbi.nlm.nih.gov/pubmed/?term=19387891 DM8SXYG DI DM8SXYG DM8SXYG DN Lamotrigine DM8SXYG MI DELOY3P DM8SXYG MN UDP-glucuronosyltransferase 1A4 (UGT1A4) DM8SXYG MT DME DM8SXYG MA Metabolism DM8SXYG RN Studies on induction of lamotrigine metabolism in transgenic UGT1 mice. Xenobiotica. 2009 Nov;39(11):826-35. DM8SXYG RU https://www.ncbi.nlm.nih.gov/pubmed/?term=19845433 DM8SXYG DI DM8SXYG DM8SXYG DN Lamotrigine DM8SXYG MI TTN9VTF DM8SXYG MN Voltage-gated sodium channel alpha Nav1.9 (SCN11A) DM8SXYG MT DTT DM8SXYG MA Blocker DM8SXYG RN The effects of lamotrigine on the acquisition and expression of morphine-induced place preference in mice. Pak J Biol Sci. 2009 Jan 1;12(1):33-9. DM8SXYG RU https://pubmed.ncbi.nlm.nih.gov/19579915 DMEH7YU DI DMEH7YU DMEH7YU DN Lanadelumab DMEH7YU MI TTMF8H9 DMEH7YU MN Plasma kallikrein (KLKB1) DMEH7YU MT DTT DMEH7YU MA Modulator DMEH7YU RN 2018 FDA drug approvals.Nat Rev Drug Discov. 2019 Feb;18(2):85-89. DMEH7YU RU https://pubmed.ncbi.nlm.nih.gov/30710142 DMG6ZU4 DI DMG6ZU4 DMG6ZU4 DN Lanreotide acetate DMG6ZU4 MI TTZ6T9E DMG6ZU4 MN Somatostatin receptor type 2 (SSTR2) DMG6ZU4 MT DTT DMG6ZU4 MA Modulator DMG6ZU4 RN Treatment strategies for acromegaly. Expert Opin Emerg Drugs. 2005 Nov;10(4):875-90. DMG6ZU4 RU https://pubmed.ncbi.nlm.nih.gov/16262568 DMXYLQ3 DI DMXYLQ3 DMXYLQ3 DN Lansoprazole DMXYLQ3 MI DEZMWRE DMXYLQ3 MN Cytochrome P450 2C18 (CYP2C18) DMXYLQ3 MT DME DMXYLQ3 MA Metabolism DMXYLQ3 RN Oxidative metabolism of lansoprazole by human liver cytochromes P450. Mol Pharmacol. 1995 Feb;47(2):410-8. DMXYLQ3 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=7870052 DMXYLQ3 DI DMXYLQ3 DMXYLQ3 DN Lansoprazole DMXYLQ3 MI DES5XRU DMXYLQ3 MN Cytochrome P450 2C8 (CYP2C8) DMXYLQ3 MT DME DMXYLQ3 MA Metabolism DMXYLQ3 RN Identification of the human P450 enzymes involved in lansoprazole metabolism. J Pharmacol Exp Ther. 1996 May;277(2):805-16. DMXYLQ3 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=8627562 DMXYLQ3 DI DMXYLQ3 DMXYLQ3 DN Lansoprazole DMXYLQ3 MI DE5IED8 DMXYLQ3 MN Cytochrome P450 2C9 (CYP2C9) DMXYLQ3 MT DME DMXYLQ3 MA Metabolism DMXYLQ3 RN Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. DMXYLQ3 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=19515014 DMXYLQ3 DI DMXYLQ3 DMXYLQ3 DN Lansoprazole DMXYLQ3 MI DE4LYSA DMXYLQ3 MN Cytochrome P450 3A4 (CYP3A4) DMXYLQ3 MT DME DMXYLQ3 MA Metabolism DMXYLQ3 RN An evaluation of the cytochrome P450 induction potential of pantoprazole in primary human hepatocytes. Chem Biol Interact. 1998 Jul 3;114(1-2):1-13. DMXYLQ3 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=9744552 DMXYLQ3 DI DMXYLQ3 DMXYLQ3 DN Lansoprazole DMXYLQ3 MI DEGTFWK DMXYLQ3 MN Mephenytoin 4-hydroxylase (CYP2C19) DMXYLQ3 MT DME DMXYLQ3 MA Metabolism DMXYLQ3 RN Effects of clarithromycin on lansoprazole pharmacokinetics between CYP2C19 genotypes. Br J Clin Pharmacol. 2005 Mar;59(3):302-9. DMXYLQ3 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=15752376 DMMJQSH DI DMMJQSH DMMJQSH DN Lanthanum carbonate DMMJQSH MI TTHOTF6 DMMJQSH MN Phosphate (PHO) DMMJQSH MT DTT DMMJQSH MA Modulator DMMJQSH RN 2004 approvals: the demise of the blockbuster. Nat Rev Drug Discov. 2005 Feb;4(2):93-4. DMMJQSH RU https://pubmed.ncbi.nlm.nih.gov/15756752 DM3BH1Y DI DM3BH1Y DM3BH1Y DN Lapatinib DM3BH1Y MI DTI7UX6 DM3BH1Y MN Breast cancer resistance protein (ABCG2) DM3BH1Y MT DTP DM3BH1Y MA Substrate DM3BH1Y RN The role of efflux and uptake transporters in [N-{3-chloro-4-[(3-fluorobenzyl)oxy]phenyl}-6-[5-({[2-(methylsulfonyl)ethyl]amino}methyl)-2-furyl]-4-quinazolinamine (GW572016, lapatinib) disposition and drug interactions. Drug Metab Dispos. 2008 Apr;36(4):695-701. DM3BH1Y RU https://doi.org/10.1124/dmd.107.018374 DM3BH1Y DI DM3BH1Y DM3BH1Y DN Lapatinib DM3BH1Y MI DES5XRU DM3BH1Y MN Cytochrome P450 2C8 (CYP2C8) DM3BH1Y MT DME DM3BH1Y MA Metabolism DM3BH1Y RN Mechanism-based inactivation of cytochrome P450 3A4 by lapatinib. Mol Pharmacol. 2010 Oct;78(4):693-703. DM3BH1Y RU https://www.ncbi.nlm.nih.gov/pubmed/?term=20624855 DM3BH1Y DI DM3BH1Y DM3BH1Y DN Lapatinib DM3BH1Y MI DE4LYSA DM3BH1Y MN Cytochrome P450 3A4 (CYP3A4) DM3BH1Y MT DME DM3BH1Y MA Metabolism DM3BH1Y RN Mechanism-based inactivation of cytochrome P450 3A4 by lapatinib. Mol Pharmacol. 2010 Oct;78(4):693-703. DM3BH1Y RU https://www.ncbi.nlm.nih.gov/pubmed/?term=20624855 DM3BH1Y DI DM3BH1Y DM3BH1Y DN Lapatinib DM3BH1Y MI DEIBDNY DM3BH1Y MN Cytochrome P450 3A5 (CYP3A5) DM3BH1Y MT DME DM3BH1Y MA Metabolism DM3BH1Y RN Clinical pharmacokinetics of tyrosine kinase inhibitors. Cancer Treat Rev. 2009 Dec;35(8):692-706. DM3BH1Y RU https://www.ncbi.nlm.nih.gov/pubmed/?term=19733976 DM3BH1Y DI DM3BH1Y DM3BH1Y DN Lapatinib DM3BH1Y MI TTGKNB4 DM3BH1Y MN Epidermal growth factor receptor (EGFR) DM3BH1Y MT DTT DM3BH1Y MA Inhibitor DM3BH1Y RN Triple negative breast cancer--current status and prospective targeted treatment based on HER1 (EGFR), TOP2A and C-MYC gene assessment. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2009 Mar;153(1):13-7. DM3BH1Y RU https://pubmed.ncbi.nlm.nih.gov/19365520 DM3BH1Y DI DM3BH1Y DM3BH1Y DN Lapatinib DM3BH1Y MI TT6EO5L DM3BH1Y MN Erbb2 tyrosine kinase receptor (HER2) DM3BH1Y MT DTT DM3BH1Y MA Inhibitor DM3BH1Y RN Triple negative breast cancer--current status and prospective targeted treatment based on HER1 (EGFR), TOP2A and C-MYC gene assessment. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2009 Mar;153(1):13-7. DM3BH1Y RU https://pubmed.ncbi.nlm.nih.gov/19365520 DM3BH1Y DI DM3BH1Y DM3BH1Y DN Lapatinib DM3BH1Y MI TT1QFLA DM3BH1Y MN Eukaryotic elongation factor 2 kinase (eEF-2K) DM3BH1Y MT DTT DM3BH1Y MA Inhibitor DM3BH1Y RN Inhibition of eEF-2 kinase sensitizes human nasopharyngeal carcinoma cells to lapatinib-induced apoptosis through the Src and Erk pathways.BMC Cancer. 2016 Oct 19;16(1):813. DM3BH1Y RU https://pubmed.ncbi.nlm.nih.gov/27756261 DM3BH1Y DI DM3BH1Y DM3BH1Y DN Lapatinib DM3BH1Y MI DEGTFWK DM3BH1Y MN Mephenytoin 4-hydroxylase (CYP2C19) DM3BH1Y MT DME DM3BH1Y MA Metabolism DM3BH1Y RN Clinical pharmacokinetics of tyrosine kinase inhibitors. Cancer Treat Rev. 2009 Dec;35(8):692-706. DM3BH1Y RU https://www.ncbi.nlm.nih.gov/pubmed/?term=19733976 DM3BH1Y DI DM3BH1Y DM3BH1Y DN Lapatinib DM3BH1Y MI DTUGYRD DM3BH1Y MN P-glycoprotein 1 (ABCB1) DM3BH1Y MT DTP DM3BH1Y MA Substrate DM3BH1Y RN Tarascon Pocket Pharmacopoeia 2018 Classic Shirt-Pocket Edition. DM3BH1Y RU https://books.google.com/books?id=0gBRDwAAQBAJ&pg=PP37&lpg=PP37&dq=Methylergonovine+transporter+uptake+efflex&source=bl&ots=cUTe_ppsmZ&sig=ACfU3U3E_YqrDg0CNEuj8K-7lci47HAnrg&hl=zh-CN&sa=X&ved=2ahUKEwjnj-Dk7d7iAhUsK6YKHd5DBDkQ6AEwEnoECAgQAQ#v=onepage&q&f=false DM26CQR DI DM26CQR DM26CQR DN Larotrectinib DM26CQR MI TTKN7QR DM26CQR MN BDNF/NT-3 growth factors receptor (TrkB) DM26CQR MT DTT DM26CQR MA Inhibitor DM26CQR RN 2018 FDA drug approvals.Nat Rev Drug Discov. 2019 Feb;18(2):85-89. DM26CQR RU https://pubmed.ncbi.nlm.nih.gov/30710142 DM26CQR DI DM26CQR DM26CQR DN Larotrectinib DM26CQR MI TTXABCW DM26CQR MN NT-3 growth factor receptor (TrkC) DM26CQR MT DTT DM26CQR MA Inhibitor DM26CQR RN 2018 FDA drug approvals.Nat Rev Drug Discov. 2019 Feb;18(2):85-89. DM26CQR RU https://pubmed.ncbi.nlm.nih.gov/30710142 DM26CQR DI DM26CQR DM26CQR DN Larotrectinib DM26CQR MI TTTDVOJ DM26CQR MN Tropomyosin-related kinase A (TrkA) DM26CQR MT DTT DM26CQR MA Inhibitor DM26CQR RN 2018 FDA drug approvals.Nat Rev Drug Discov. 2019 Feb;18(2):85-89. DM26CQR RU https://pubmed.ncbi.nlm.nih.gov/30710142 DMSQ1JV DI DMSQ1JV DMSQ1JV DN LAS-34273 DMSQ1JV MI TTQ13Z5 DMSQ1JV MN Muscarinic acetylcholine receptor M3 (CHRM3) DMSQ1JV MT DTT DMSQ1JV MA Antagonist DMSQ1JV RN Emerging drugs for the treatment of chronic obstructive pulmonary disease. Expert Opin Emerg Drugs. 2006 May;11(2):275-91. DMSQ1JV RU https://pubmed.ncbi.nlm.nih.gov/16634702 DMXLVDT DI DMXLVDT DMXLVDT DN Lasmiditan DMXLVDT MI TT0MI3F DMXLVDT MN 5-HT 1F receptor (HTR1F) DMXLVDT MT DTT DMXLVDT MA Agonist DMXLVDT RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health Human Services. 2019 DMXLVDT RU https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/211280s000lbl.pdf DMHA18P DI DMHA18P DMHA18P DN Lasofoxifene DMHA18P MI TTZAYWL DMHA18P MN Estrogen receptor (ESR) DMHA18P MT DTT DMHA18P MA Modulator DMHA18P RN Pfizer. Product Development Pipeline. March 31 2009. DMHA18P RU http://media.pfizer.com/files/research/pipeline/2009_0331/pipeline_2009_0331.pdf DMHA18P DI DMHA18P DMHA18P DN Lasofoxifene DMHA18P MI TT57ID8 DMHA18P MN Respiratory syncytial virus protein F (RSV F) DMHA18P MT DTT DMHA18P MA Modulator DMHA18P RN Prospects for the development of fusion inhibitors to treat human respiratory syncytial virus infection. Curr Opin Drug Discov Devel. 2009 Jul;12(4):479-87. DMHA18P RU https://pubmed.ncbi.nlm.nih.gov/19562644 DMANL0D DI DMANL0D DMANL0D DN Latamoxef DMANL0D MI TT85JMW DMANL0D MN Bacterial Penicillin binding protein 3 (Bact mrcA) DMANL0D MT DTT DMANL0D MA Binder DMANL0D RN Clinical relevance of antibiotic-induced endotoxin release in patients undergoing hepatic resection. World J Surg. 1999 Jan;23(1):75-9. DMANL0D RU https://pubmed.ncbi.nlm.nih.gov/9841767 DMANL0D DI DMANL0D DMANL0D DN Latamoxef DMANL0D MI DT8QKNP DMANL0D MN Peptide transporter 2 (SLC15A2) DMANL0D MT DTP DMANL0D MA Substrate DMANL0D RN Transport characteristics of a novel peptide transporter 1 substrate, antihypotensive drug midodrine, and its amino acid derivatives. J Pharmacol Exp Ther. 2006 Jul;318(1):455-60. DMANL0D RU http://www.ncbi.nlm.nih.gov/pubmed/16597710 DMI5OXG DI DMI5OXG DMI5OXG DN Latanoprost DMI5OXG MI DT021JD DMI5OXG MN Organic anion transporting polypeptide 2A1 (SLCO2A1) DMI5OXG MT DTP DMI5OXG MA Substrate DMI5OXG RN The prostaglandin transporter OATP2A1 is expressed in human ocular tissues and transports the antiglaucoma prostanoid latanoprost. Invest Ophthalmol Vis Sci. 2010 May;51(5):2504-11. DMI5OXG RU http://www.ncbi.nlm.nih.gov/pubmed/20019365 DMI5OXG DI DMI5OXG DMI5OXG DN Latanoprost DMI5OXG MI DTPFTEQ DMI5OXG MN Organic anion transporting polypeptide 2B1 (SLCO2B1) DMI5OXG MT DTP DMI5OXG MA Substrate DMI5OXG RN The prostaglandin transporter OATP2A1 is expressed in human ocular tissues and transports the antiglaucoma prostanoid latanoprost. Invest Ophthalmol Vis Sci. 2010 May;51(5):2504-11. DMI5OXG RU http://www.ncbi.nlm.nih.gov/pubmed/20019365 DMI5OXG DI DMI5OXG DMI5OXG DN Latanoprost DMI5OXG MI TTT2ZAR DMI5OXG MN Prostaglandin F2-alpha receptor (PTGFR) DMI5OXG MT DTT DMI5OXG MA Agonist DMI5OXG RN PGF(2alpha) FP receptor contributes to brain damage following transient focal brain ischemia. Neurotox Res. 2009 Jan;15(1):62-70. DMI5OXG RU https://pubmed.ncbi.nlm.nih.gov/19384589 DMLFX7K DI DMLFX7K DMLFX7K DN LCZ696 DMLFX7K MI TT5TKPM DMLFX7K MN Neutral endopeptidase (MME) DMLFX7K MT DTT DMLFX7K MA Modulator DMLFX7K RN 2014 FDA drug approvals. Nat Rev Drug Discov. 2015 Feb;14(2):77-81. DMLFX7K RU https://pubmed.ncbi.nlm.nih.gov/25633781 DME6G97 DI DME6G97 DME6G97 DN Lefamulin DME6G97 MI TTLFGBV DME6G97 MN Bacterial 23S ribosomal RNA (Bact 23S rRNA) DME6G97 MT DTT DME6G97 MA Inhibitor DME6G97 RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health Human Services. 2019 DME6G97 RU https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/211672s000,211673s000lbl.pdf DME6G97 DI DME6G97 DME6G97 DN Lefamulin DME6G97 MI DE4LYSA DME6G97 MN Cytochrome P450 3A4 (CYP3A4) DME6G97 MT DME DME6G97 MA Metabolism DME6G97 RN Lefamulin: review of a promising novel pleuromutilin antibiotic. Pharmacotherapy. 2018 Sep;38(9):935-946. DME6G97 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=30019769 DMR8ONJ DI DMR8ONJ DMR8ONJ DN Leflunomide DMR8ONJ MI DTI7UX6 DMR8ONJ MN Breast cancer resistance protein (ABCG2) DMR8ONJ MT DTP DMR8ONJ MA Substrate DMR8ONJ RN Leflunomide and its metabolite A771726 are high affinity substrates of BCRP: implications for drug resistance. Ann Rheum Dis. 2009 Jul;68(7):1201-7. DMR8ONJ RU http://www.ncbi.nlm.nih.gov/pubmed/18397960 DMR8ONJ DI DMR8ONJ DMR8ONJ DN Leflunomide DMR8ONJ MI DEJGDUW DMR8ONJ MN Cytochrome P450 1A2 (CYP1A2) DMR8ONJ MT DME DMR8ONJ MA Metabolism DMR8ONJ RN Synthetic and natural compounds that interact with human cytochrome P450 1A2 and implications in drug development. Curr Med Chem. 2009;16(31):4066-218. DMR8ONJ RU https://www.ncbi.nlm.nih.gov/pubmed/?term=19754423 DMR8ONJ DI DMR8ONJ DMR8ONJ DN Leflunomide DMR8ONJ MI DE5IED8 DMR8ONJ MN Cytochrome P450 2C9 (CYP2C9) DMR8ONJ MT DME DMR8ONJ MA Metabolism DMR8ONJ RN Leflunomide-induced acute hepatitis. Dig Liver Dis. 2004 Jan;36(1):82-4. DMR8ONJ RU https://www.ncbi.nlm.nih.gov/pubmed/?term=14971821 DMR8ONJ DI DMR8ONJ DMR8ONJ DN Leflunomide DMR8ONJ MI DE4LYSA DMR8ONJ MN Cytochrome P450 3A4 (CYP3A4) DMR8ONJ MT DME DMR8ONJ MA Metabolism DMR8ONJ RN Prediction of drug-induced liver injury in HepG2 cells cultured with human liver microsomes. Chem Res Toxicol. 2015 May 18;28(5):872-85. DMR8ONJ RU https://www.ncbi.nlm.nih.gov/pubmed/?term=25860621 DMR8ONJ DI DMR8ONJ DMR8ONJ DN Leflunomide DMR8ONJ MI TT3PQ2Y DMR8ONJ MN Plasmodium Dihydroorotate dehydrogenase (Malaria DHOdehase) DMR8ONJ MT DTT DMR8ONJ MA Inhibitor DMR8ONJ RN Identification and characterization of potential new therapeutic targets in inflammatory and autoimmune diseases. Eur J Biochem. 1999 Dec;266(3):1184-91. DMR8ONJ RU https://pubmed.ncbi.nlm.nih.gov/10583416 DM6Q7U4 DI DM6Q7U4 DM6Q7U4 DN Lenalidomide DM6Q7U4 MI DTUGYRD DM6Q7U4 MN P-glycoprotein 1 (ABCB1) DM6Q7U4 MT DTP DM6Q7U4 MA Substrate DM6Q7U4 RN DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. (ID: DB00480) DM6Q7U4 RU https://www.drugbank.ca/drugs/DB00480 DM6Q7U4 DI DM6Q7U4 DM6Q7U4 DN Lenalidomide DM6Q7U4 MI TTF8CQI DM6Q7U4 MN Tumor necrosis factor (TNF) DM6Q7U4 MT DTT DM6Q7U4 MA Inhibitor DM6Q7U4 RN Thalidomide and thalidomide analogues for maintenance of remission in Crohn's disease. Cochrane Database Syst Rev. 2009 Apr 15;(2):CD007351. DM6Q7U4 RU https://pubmed.ncbi.nlm.nih.gov/19370685 DMB1IU4 DI DMB1IU4 DMB1IU4 DN Lenvatinib DMB1IU4 MI DTUGYRD DMB1IU4 MN P-glycoprotein 1 (ABCB1) DMB1IU4 MT DTP DMB1IU4 MA Substrate DMB1IU4 RN Influence of CYP3A4/5 and ABC transporter polymorphisms on lenvatinib plasma trough concentrations in Japanese patients with thyroid cancer. Sci Rep. 2019 Apr 1;9(1):5404. DMB1IU4 RU http://www.ncbi.nlm.nih.gov/pubmed/30931962 DMB1IU4 DI DMB1IU4 DMB1IU4 DN Lenvatinib DMB1IU4 MI TTUTJGQ DMB1IU4 MN Vascular endothelial growth factor receptor 2 (KDR) DMB1IU4 MT DTT DMB1IU4 MA Inhibitor DMB1IU4 RN Emerging drugs for ovarian cancer. Expert Opin Emerg Drugs. 2008 Sep;13(3):523-36. DMB1IU4 RU https://pubmed.ncbi.nlm.nih.gov/18764727 DM1I3D5 DI DM1I3D5 DM1I3D5 DN Lepirudin DM1I3D5 MI TT6L509 DM1I3D5 MN Coagulation factor IIa (F2) DM1I3D5 MT DTT DM1I3D5 MA Inhibitor DM1I3D5 RN Recombinant hirudin (lepirudin) as anticoagulant in intensive care patients treated with continuous hemodialysis. Kidney Int Suppl. 1999 Nov;(72):S46-50. DM1I3D5 RU https://pubmed.ncbi.nlm.nih.gov/10560805 DMPWSEM DI DMPWSEM DMPWSEM DN Lercanidipine DMPWSEM MI DE4LYSA DMPWSEM MN Cytochrome P450 3A4 (CYP3A4) DMPWSEM MT DME DMPWSEM MA Metabolism DMPWSEM RN Lercanidipine in hypertension. Vasc Health Risk Manag. 2005;1(3):173-82. DMPWSEM RU https://www.ncbi.nlm.nih.gov/pubmed/?term=17319103 DMPWSEM DI DMPWSEM DMPWSEM DN Lercanidipine DMPWSEM MI DEIBDNY DMPWSEM MN Cytochrome P450 3A5 (CYP3A5) DMPWSEM MT DME DMPWSEM MA Metabolism DMPWSEM RN Drug Interactions Flockhart Table DMPWSEM RU https://drug-interactions.medicine.iu.edu/Main-Table.aspx DMPWSEM DI DMPWSEM DMPWSEM DN Lercanidipine DMPWSEM MI DERD86B DMPWSEM MN Cytochrome P450 3A7 (CYP3A7) DMPWSEM MT DME DMPWSEM MA Metabolism DMPWSEM RN Drug Interactions Flockhart Table DMPWSEM RU https://drug-interactions.medicine.iu.edu/Main-Table.aspx DMPWSEM DI DMPWSEM DMPWSEM DN Lercanidipine DMPWSEM MI TTFK1JQ DMPWSEM MN Voltage-gated calcium channel alpha-2/delta-1 (CACNA2D1) DMPWSEM MT DTT DMPWSEM MA Blocker DMPWSEM RN Treatment of essential hypertension with calcium channel blockers: what is the place of lercanidipine Expert Opin Drug Metab Toxicol. 2009 Aug;5(8):981-7. DMPWSEM RU https://pubmed.ncbi.nlm.nih.gov/19619074 DMUR64T DI DMUR64T DMUR64T DN Lesinurad DMUR64T MI DE5IED8 DMUR64T MN Cytochrome P450 2C9 (CYP2C9) DMUR64T MT DME DMUR64T MA Metabolism DMUR64T RN FDA Label of Lesinurad. The 2020 official website of the U.S. Food and Drug Administration. DMUR64T RU https://www.accessdata.fda.gov/drugsatfda_docs/label/2015/207988lbl.pdf DMUR64T DI DMUR64T DMUR64T DN Lesinurad DMUR64T MI TTA592U DMUR64T MN Urate anion exchanger 1 (URAT1) DMUR64T MT DTT DMUR64T MA Modulator DMUR64T RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1031). DMUR64T RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1031 DMQ2AIJ DI DMQ2AIJ DMQ2AIJ DN Lestaurtinib DMQ2AIJ MI TTGJCWZ DMQ2AIJ MN Fms-like tyrosine kinase 3 (FLT-3) DMQ2AIJ MT DTT DMQ2AIJ MA Modulator DMQ2AIJ RN Lestaurtinib (CEP701) is a JAK2 inhibitor that suppresses JAK2/STAT5 signaling and the proliferation of primary erythroid cells from patients with ... Blood. 2008 Jun 15;111(12):5663-71. DMQ2AIJ RU https://pubmed.ncbi.nlm.nih.gov/17984313 DMH07Y3 DI DMH07Y3 DMH07Y3 DN Letrozole DMH07Y3 MI TTSZLWK DMH07Y3 MN Aromatase (CYP19A1) DMH07Y3 MT DTT DMH07Y3 MA Inhibitor DMH07Y3 RN Aromatase inhibitors--theoretical concept and present experiences in the treatment of endometriosis. Zentralbl Gynakol. 2003 Jul-Aug;125(7-8):247-51. DMH07Y3 RU https://pubmed.ncbi.nlm.nih.gov/14505258 DMH07Y3 DI DMH07Y3 DMH07Y3 DN Letrozole DMH07Y3 MI DEQX145 DMH07Y3 MN Aromatase (CYP19A1) DMH07Y3 MT DME DMH07Y3 MA Metabolism DMH07Y3 RN Double-blind, randomised, multicentre endocrine trial comparing two letrozole doses, in postmenopausal breast cancer patients. Eur J Cancer. 1999 Feb;35(2):208-13. DMH07Y3 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=10448261 DMH07Y3 DI DMH07Y3 DMH07Y3 DN Letrozole DMH07Y3 MI DEJVYAZ DMH07Y3 MN Cytochrome P450 2A6 (CYP2A6) DMH07Y3 MT DME DMH07Y3 MA Metabolism DMH07Y3 RN Letrozole concentration is associated with CYP2A6 variation but not with arthralgia in patients with breast cancer. Breast Cancer Res Treat. 2018 Nov;172(2):371-379. DMH07Y3 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=30094551 DMH07Y3 DI DMH07Y3 DMH07Y3 DN Letrozole DMH07Y3 MI DE4LYSA DMH07Y3 MN Cytochrome P450 3A4 (CYP3A4) DMH07Y3 MT DME DMH07Y3 MA Metabolism DMH07Y3 RN Inhibition of drug metabolizing cytochrome P450s by the aromatase inhibitor drug letrozole and its major oxidative metabolite 4,4'-methanol-bisbenzonitrile in vitro. Cancer Chemother Pharmacol. 2009 Oct;64(5):867-75. DMH07Y3 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=19198839 DMUAZWG DI DMUAZWG DMUAZWG DN Leucovorin DMUAZWG MI DTFI42L DMUAZWG MN Multidrug resistance-associated protein 2 (ABCC2) DMUAZWG MT DTP DMUAZWG MA Substrate DMUAZWG RN Transport of methotrexate, methotrexate polyglutamates, and 17beta-estradiol 17-(beta-D-glucuronide) by ABCG2: effects of acquired mutations at R482 on methotrexate transport. Cancer Res. 2003 Jul 15;63(14):4048-54. DMUAZWG RU http://www.ncbi.nlm.nih.gov/pubmed/12874005 DMUAZWG DI DMUAZWG DMUAZWG DN Leucovorin DMUAZWG MI DTQ3ZHF DMUAZWG MN Multidrug resistance-associated protein 3 (ABCC3) DMUAZWG MT DTP DMUAZWG MA Substrate DMUAZWG RN Transport of methotrexate (MTX) and folates by multidrug resistance protein (MRP) 3 and MRP1: effect of polyglutamylation on MTX transport. Cancer Res. 2001 Oct 1;61(19):7225-32. DMUAZWG RU http://www.ncbi.nlm.nih.gov/pubmed/11585759 DMUAZWG DI DMUAZWG DMUAZWG DN Leucovorin DMUAZWG MI DTCSGPB DMUAZWG MN Multidrug resistance-associated protein 4 (ABCC4) DMUAZWG MT DTP DMUAZWG MA Substrate DMUAZWG RN Analysis of methotrexate and folate transport by multidrug resistance protein 4 (ABCC4): MRP4 is a component of the methotrexate efflux system. Cancer Res. 2002 Jun 1;62(11):3144-50. DMUAZWG RU http://www.ncbi.nlm.nih.gov/pubmed/12036927 DMNWZJG DI DMNWZJG DMNWZJG DN Leucovorin Calcium DMNWZJG MI TTYZVDJ DMNWZJG MN Dihydrofolate reductase (DHFR) DMNWZJG MT DTT DMNWZJG MA Modulator DMNWZJG RN Biochemical factors in the selectivity of leucovorin rescue: selective inhibition of leucovorin reactivation of dihydrofolate reductase and leucovorin utilization in purine and pyrimidine biosynthesis by methotrexate and dihydrofolate polyglutamates.NCI Monogr.1987;(5):17-26. DMNWZJG RU https://www.ncbi.nlm.nih.gov/pubmed/2448654 DMZT4N7 DI DMZT4N7 DMZT4N7 DN Leucovorin/5-fluorouracil DMZT4N7 MI TTU6BFZ DMZT4N7 MN Candida Thymidylate synthase (Candi TMP1) DMZT4N7 MT DTT DMZT4N7 MA Inhibitor DMZT4N7 RN Decreased levels of UMP kinase as a mechanism of fluoropyrimidine resistance. Mol Cancer Ther. 2009 May;8(5):1037-44. DMZT4N7 RU https://pubmed.ncbi.nlm.nih.gov/19383847 DM5XPIJ DI DM5XPIJ DM5XPIJ DN Leuprolide DM5XPIJ MI TT0ID4A DM5XPIJ MN Leutinizing-hormone-releasing hormone (GNRH1) DM5XPIJ MT DTT DM5XPIJ MA Activator DM5XPIJ RN Increased risk of metabolic syndrome, diabetes mellitus, and cardiovascular disease in men receiving androgen deprivation therapy for prostate cancer. Pharmacotherapy. 2008 Dec;28(12):1511-22. DM5XPIJ RU https://pubmed.ncbi.nlm.nih.gov/19025432 DM15HAT DI DM15HAT DM15HAT DN Leuprorelin acetate DM15HAT MI TT8R70G DM15HAT MN Gonadotropin-releasing hormone receptor (GNRHR) DM15HAT MT DTT DM15HAT MA Agonist DM15HAT RN Clinical pipeline report, company report or official report of Takeda (2009). DM15HAT RU http://www.takeda.com/pdf/usr/default/10_1_34992_2.pdf DMJBOCR DI DMJBOCR DMJBOCR DN Levacecarnine HCL DMJBOCR MI DTW7AE3 DMJBOCR MN Alanine/serine/cysteine/threonine transporter 2 (SLC1A5) DMJBOCR MT DTP DMJBOCR MA Substrate DMJBOCR RN A polarized localization of amino acid/carnitine transporter B(0,+) (ATB(0,+)) in the blood-brain barrier. Biochem Biophys Res Commun. 2008 Nov 14;376(2):267-70. DMJBOCR RU http://www.ncbi.nlm.nih.gov/pubmed/18771654 DMJBOCR DI DMJBOCR DMJBOCR DN Levacecarnine HCL DMJBOCR MI DEIGQCY DMJBOCR MN Carnitine O-acetyltransferase (CRAT) DMJBOCR MT DME DMJBOCR MA Metabolism DMJBOCR RN Structural and mutational characterization of L-carnitine binding to human carnitine acetyltransferase. J Struct Biol. 2004 Jun;146(3):416-24. DMJBOCR RU https://www.ncbi.nlm.nih.gov/pubmed/?term=15099582 DMJBOCR DI DMJBOCR DMJBOCR DN Levacecarnine HCL DMJBOCR MI TTDL0NY DMJBOCR MN Carnitine O-palmitoyltransferase I (CPT1B) DMJBOCR MT DTT DMJBOCR MA Activator DMJBOCR RN Central ghrelin regulates peripheral lipid metabolism in a growth hormone-independent fashion. Endocrinology. 2009 Oct;150(10):4562-74. DMJBOCR RU https://pubmed.ncbi.nlm.nih.gov/19608647 DMJBOCR DI DMJBOCR DMJBOCR DN Levacecarnine HCL DMJBOCR MI DTQOUM4 DMJBOCR MN Carnitine/acylcarnitine translocase (SLC25A20) DMJBOCR MT DTP DMJBOCR MA Substrate DMJBOCR RN Molecular and functional analysis of SLC25A20 mutations causing carnitine-acylcarnitine translocase deficiency. Hum Mutat. 2004 Oct;24(4):312-20. DMJBOCR RU http://www.ncbi.nlm.nih.gov/pubmed/15365988 DMJBOCR DI DMJBOCR DMJBOCR DN Levacecarnine HCL DMJBOCR MI DEVDYN7 DMJBOCR MN Cytochrome P450 2E1 (CYP2E1) DMJBOCR MT DME DMJBOCR MA Metabolism DMJBOCR RN Modulation of ethanol-mediated CYP2E1 induction by clofibrate and L-carnitine in rat liver. Biol Pharm Bull. 1993 Dec;16(12):1240-3. DMJBOCR RU https://www.ncbi.nlm.nih.gov/pubmed/?term=8130774 DMJBOCR DI DMJBOCR DMJBOCR DN Levacecarnine HCL DMJBOCR MI DTPATLS DMJBOCR MN Fly-like putative transporter 2 (SLC22A16) DMJBOCR MT DTP DMJBOCR MA Substrate DMJBOCR RN The human carnitine transporter SLC22A16 mediates high affinity uptake of the anticancer polyamine analogue bleomycin-A5. J Biol Chem. 2010 Feb 26;285(9):6275-84. DMJBOCR RU http://www.ncbi.nlm.nih.gov/pubmed/20037140 DMJBOCR DI DMJBOCR DMJBOCR DN Levacecarnine HCL DMJBOCR MI DTQK5O9 DMJBOCR MN Monocarboxylate transporter 9 (SLC16A9) DMJBOCR MT DTP DMJBOCR MA Substrate DMJBOCR RN Histological characterization of orphan transporter MCT14 (SLC16A14) shows abundant expression in mouse CNS and kidney. BMC Neurosci. 2016 Jul 1;17(1):43. DMJBOCR RU http://www.ncbi.nlm.nih.gov/pubmed/27364523 DMJBOCR DI DMJBOCR DMJBOCR DN Levacecarnine HCL DMJBOCR MI DT2EG60 DMJBOCR MN Organic cation/carnitine transporter 1 (SLC22A4) DMJBOCR MT DTP DMJBOCR MA Substrate DMJBOCR RN Spontaneous development of intestinal and colonic atrophy and inflammation in the carnitine-deficient jvs (OCTN2(-/-)) mice. Mol Genet Metab. 2007 Dec;92(4):315-24. DMJBOCR RU http://www.ncbi.nlm.nih.gov/pubmed/17884651 DMJBOCR DI DMJBOCR DMJBOCR DN Levacecarnine HCL DMJBOCR MI DT3HUVD DMJBOCR MN Organic cation/carnitine transporter 2 (SLC22A5) DMJBOCR MT DTP DMJBOCR MA Substrate DMJBOCR RN Colistin is substrate of the carnitine/organic cation transporter 2 (OCTN2, SLC22A5). Drug Metab Dispos. 2017 Dec;45(12):1240-1244. DMJBOCR RU http://www.ncbi.nlm.nih.gov/pubmed/28986476 DM5YBO1 DI DM5YBO1 DM5YBO1 DN Levalbuterol DM5YBO1 MI TT2CJVK DM5YBO1 MN Adrenergic receptor beta-2 (ADRB2) DM5YBO1 MT DTT DM5YBO1 MA Antagonist DM5YBO1 RN Beta-blockers in the treatment of hypertension: are there clinically relevant differences Postgrad Med. 2009 May;121(3):90-8. DM5YBO1 RU https://pubmed.ncbi.nlm.nih.gov/19491545 DMCOLUP DI DMCOLUP DMCOLUP DN Levallorphan DMCOLUP MI TTF4E0J DMCOLUP MN Neuronal acetylcholine receptor alpha-2 (CHRNA2) DMCOLUP MT DTT DMCOLUP MA Antagonist DMCOLUP RN Synergy between pairs of competitive antagonists at adult human muscle acetylcholine receptors. Anesth Analg. 2008 Aug;107(2):525-33. DMCOLUP RU https://pubmed.ncbi.nlm.nih.gov/18633030 DM5EN79 DI DM5EN79 DM5EN79 DN Levamisole DM5EN79 MI TTMR5UV DM5EN79 MN Alkaline phosphatase tissue-nonspecific (ALPL) DM5EN79 MT DTT DM5EN79 MA Inhibitor DM5EN79 RN Characterization of rat heart alkaline phosphatase isoenzymes and modulation of activity. Braz J Med Biol Res. 2008 Jul;41(7):600-9. DM5EN79 RU https://pubmed.ncbi.nlm.nih.gov/18719742 DMTGDN8 DI DMTGDN8 DMTGDN8 DN Levetiracetam DMTGDN8 MI TTPC4TU DMTGDN8 MN 5-HT 3A receptor (HTR3A) DMTGDN8 MT DTT DMTGDN8 MA Antagonist DMTGDN8 RN Emerging therapies for fibromyalgia. Expert Opin Emerg Drugs. 2008 Mar;13(1):53-62. DMTGDN8 RU https://pubmed.ncbi.nlm.nih.gov/18321148 DMTGDN8 DI DMTGDN8 DMTGDN8 DN Levetiracetam DMTGDN8 MI DTUGYRD DMTGDN8 MN P-glycoprotein 1 (ABCB1) DMTGDN8 MT DTP DMTGDN8 MA Substrate DMTGDN8 RN Differences in the transport of the antiepileptic drugs phenytoin, levetiracetam and carbamazepine by human and mouse P-glycoprotein. Neuropharmacology. 2007 Feb;52(2):333-46. DMTGDN8 RU http://www.ncbi.nlm.nih.gov/pubmed/17045309 DMTGDN8 DI DMTGDN8 DMTGDN8 DN Levetiracetam DMTGDN8 MI TTT3P91 DMTGDN8 MN Synaptic vesicle glycoprotein 2A (SV2A) DMTGDN8 MT DTT DMTGDN8 MA Modulator DMTGDN8 RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. DMTGDN8 RU https://www.fda.gov/ DMSREPX DI DMSREPX DMSREPX DN Levobetaxolol DMSREPX MI TTR6W5O DMSREPX MN Adrenergic receptor beta-1 (ADRB1) DMSREPX MT DTT DMSREPX MA Antagonist DMSREPX RN Binding affinities of ocular hypotensive beta-blockers levobetaxolol, levobunolol, and timolol at endogenous guinea pig beta-adrenoceptors. J Ocul Pharmacol Ther. 2004 Apr;20(2):93-9. DMSREPX RU https://pubmed.ncbi.nlm.nih.gov/15117564 DMSREPX DI DMSREPX DMSREPX DN Levobetaxolol DMSREPX MI DECB0K3 DMSREPX MN Cytochrome P450 2D6 (CYP2D6) DMSREPX MT DME DMSREPX MA Metabolism DMSREPX RN Application of substrate depletion assay to evaluation of CYP isoforms responsible for stereoselective metabolism of carvedilol. Drug Metab Pharmacokinet. 2016 Dec;31(6):425-432. DMSREPX RU https://www.ncbi.nlm.nih.gov/pubmed/?term=27836712 DMTNFCQ DI DMTNFCQ DMTNFCQ DN Levobunolol DMTNFCQ MI TTR6W5O DMTNFCQ MN Adrenergic receptor beta-1 (ADRB1) DMTNFCQ MT DTT DMTNFCQ MA Antagonist DMTNFCQ RN Binding of beta-adrenoceptor antagonists to rat and rabbit lung: special reference to levobunolol. Arzneimittelforschung. 1984;34(5):579-84. DMTNFCQ RU https://pubmed.ncbi.nlm.nih.gov/6147147 DMTNFCQ DI DMTNFCQ DMTNFCQ DN Levobunolol DMTNFCQ MI DECB0K3 DMTNFCQ MN Cytochrome P450 2D6 (CYP2D6) DMTNFCQ MT DME DMTNFCQ MA Metabolism DMTNFCQ RN Application of substrate depletion assay to evaluation of CYP isoforms responsible for stereoselective metabolism of carvedilol. Drug Metab Pharmacokinet. 2016 Dec;31(6):425-432. DMTNFCQ RU https://www.ncbi.nlm.nih.gov/pubmed/?term=27836712 DM783CH DI DM783CH DM783CH DN Levobupivacaine DM783CH MI DEJGDUW DM783CH MN Cytochrome P450 1A2 (CYP1A2) DM783CH MT DME DM783CH MA Metabolism DM783CH RN Pharmacokinetics of levobupivacaine after caudal epidural administration in infants less than 3 months of age. Br J Anaesth. 2005 Oct;95(4):524-9. DM783CH RU https://www.ncbi.nlm.nih.gov/pubmed/?term=16100236 DM783CH DI DM783CH DM783CH DN Levobupivacaine DM783CH MI DE4LYSA DM783CH MN Cytochrome P450 3A4 (CYP3A4) DM783CH MT DME DM783CH MA Metabolism DM783CH RN Clinical profile of levobupivacaine in regional anesthesia: A systematic review. J Anaesthesiol Clin Pharmacol. 2013 Oct;29(4):530-9. DM783CH RU https://www.ncbi.nlm.nih.gov/pubmed/?term=24249993 DM783CH DI DM783CH DM783CH DN Levobupivacaine DM783CH MI TTRK8B9 DM783CH MN Sodium channel unspecific (NaC) DM783CH MT DTT DM783CH MA Blocker DM783CH RN Block of neuronal tetrodotoxin-resistant Na+ currents by stereoisomers of piperidine local anesthetics. Anesth Analg. 2000 Dec;91(6):1499-505. DM783CH RU https://pubmed.ncbi.nlm.nih.gov/11094008 DMMZPWT DI DMMZPWT DMMZPWT DN Levocabastine DMMZPWT MI TTTIBOJ DMMZPWT MN Histamine H1 receptor (H1R) DMMZPWT MT DTT DMMZPWT MA Antagonist DMMZPWT RN Contribution of alpha4beta1 integrin to the antiallergic effect of levocabastine. Biochem Pharmacol. 2008 Sep 15;76(6):751-62. DMMZPWT RU https://pubmed.ncbi.nlm.nih.gov/18680729 DMQYLGP DI DMQYLGP DMQYLGP DN Levocetirizine DMQYLGP MI DT06JWZ DMQYLGP MN Organic anion transporter 4 (SLC22A11) DMQYLGP MT DTP DMQYLGP MA Substrate DMQYLGP RN Cellular Uptake of Levocetirizine by Organic Anion Transporter 4. J Pharm Sci. 2017 Sep;106(9):2895-2898. DMQYLGP RU http://www.ncbi.nlm.nih.gov/pubmed/28385546 DMW6ZJI DI DMW6ZJI DMW6ZJI DN Levocetirizine dihydrochloride DMW6ZJI MI DE4LYSA DMW6ZJI MN Cytochrome P450 3A4 (CYP3A4) DMW6ZJI MT DME DMW6ZJI MA Metabolism DMW6ZJI RN FDA label of Levocetirizine dihydrochloride. The 2020 official website of the U.S. Food and Drug Administration. DMW6ZJI RU https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/022064s038,022157s020lbl.pdf DMW6ZJI DI DMW6ZJI DMW6ZJI DN Levocetirizine dihydrochloride DMW6ZJI MI TTTIBOJ DMW6ZJI MN Histamine H1 receptor (H1R) DMW6ZJI MT DTT DMW6ZJI MA Antagonist DMW6ZJI RN Update on prescription and over-the-counter histamine inverse agonists in rhinitis therapy. Curr Allergy Asthma Rep. 2009 Mar;9(2):140-8. DMW6ZJI RU https://pubmed.ncbi.nlm.nih.gov/19210904 DMN3E57 DI DMN3E57 DMN3E57 DN Levodopa DMN3E57 MI DECB0K3 DMN3E57 MN Cytochrome P450 2D6 (CYP2D6) DMN3E57 MT DME DMN3E57 MA Metabolism DMN3E57 RN Multiple cytochrome P450 enzymes responsible for the oxidative metabolism of the substituted (S)-3-phenylpiperidine, (S,S)-3-[3-(methylsulfonyl)phenyl]-1-propylpiperidine hydrochloride, in human liver microsomes. Drug Metab Dispos. 2002 Dec;30(12):1372-7. DMN3E57 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=12433806 DMN3E57 DI DMN3E57 DMN3E57 DN Levodopa DMN3E57 MI DETK9CN DMN3E57 MN DOPA decarboxylase (DDC) DMN3E57 MT DME DMN3E57 MA Metabolism DMN3E57 RN Complexity of dopamine metabolism. Cell Commun Signal. 2013 May 17;11(1):34. DMN3E57 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=23683503 DMN3E57 DI DMN3E57 DMN3E57 DN Levodopa DMN3E57 MI TTEX248 DMN3E57 MN Dopamine D2 receptor (D2R) DMN3E57 MT DTT DMN3E57 MA Modulator DMN3E57 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 3639). DMN3E57 RU http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=3639 DMN3E57 DI DMN3E57 DMN3E57 DN Levodopa DMN3E57 MI DT48T0N DMN3E57 MN L-type amino acid transporter 1 (SLC7A5) DMN3E57 MT DTP DMN3E57 MA Substrate DMN3E57 RN Modulation of LAT1 (SLC7A5) transporter activity and stability by membrane cholesterol. Sci Rep. 2017 Mar 8;7:43580. DMN3E57 RU http://www.ncbi.nlm.nih.gov/pubmed/28272458 DMN3E57 DI DMN3E57 DMN3E57 DN Levodopa DMN3E57 MI DTUGYRD DMN3E57 MN P-glycoprotein 1 (ABCB1) DMN3E57 MT DTP DMN3E57 MA Substrate DMN3E57 RN Human intestinal transporter database: QSAR modeling and virtual profiling of drug uptake, efflux and interactions. Pharm Res. 2013 Apr;30(4):996-1007. DMN3E57 RU https://doi.org/10.1007/s11095-012-0935-x DMN3E57 DI DMN3E57 DMN3E57 DN Levodopa DMN3E57 MI DEFQ8VO DMN3E57 MN Thiopurine methyltransferase (TPMT) DMN3E57 MT DME DMN3E57 MA Metabolism DMN3E57 RN Reduced 3-O-methyl-dopa levels in OCD patients and their unaffected parents is associated with the low activity M158 COMT allele. Am J Med Genet B Neuropsychiatr Genet. 2010 Mar 5;153B(2):542-548. DMN3E57 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=19676096 DMN3E57 DI DMN3E57 DMN3E57 DN Levodopa DMN3E57 MI DE3HL9N DMN3E57 MN Tyrosine decarboxylase (tdc) DMN3E57 MT DME DMN3E57 MA Metabolism DMN3E57 RN Discovery and inhibition of an interspecies gut bacterial pathway for Levodopa metabolism. Science. 2019 Jun 14;364(6445). pii: eaau6323. DMN3E57 RU https://pubmed.ncbi.nlm.nih.gov/31196984 DMN3E57 DI DMN3E57 DMN3E57 DN Levodopa DMN3E57 MI DEX2ZLF DMN3E57 MN Tyrosine decarboxylase (tdc) DMN3E57 MT DME DMN3E57 MA Metabolism DMN3E57 RN Gut bacterial tyrosine decarboxylases restrict levels of levodopa in the treatment of Parkinson's disease. Nat Commun. 2019 Jan 18;10(1):310. DMN3E57 RU https://pubmed.ncbi.nlm.nih.gov/30659181 DMS60RB DI DMS60RB DMS60RB DN Levofloxacin DMS60RB MI TTN6J5F DMS60RB MN Bacterial DNA gyrase (Bact gyrase) DMS60RB MT DTT DMS60RB MA Modulator DMS60RB RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. DMS60RB RU https://www.fda.gov/ DMS60RB DI DMS60RB DMS60RB DN Levofloxacin DMS60RB MI DEP0IWS DMS60RB MN Beta-lactamase (blaB) DMS60RB MT DME DMS60RB MA Metabolism DMS60RB RN Analysis of the drug-resistant characteristics of Klebsiella pneumoniae isolated from the respiratory tract and CTX-M ESBL genes. Genet Mol Res. 2015 Oct 5;14(4):12043-8. DMS60RB RU https://pubmed.ncbi.nlm.nih.gov/26505351 DMS60RB DI DMS60RB DMS60RB DN Levofloxacin DMS60RB MI DTE2B1D DMS60RB MN Organic anion transporting polypeptide 1A2 (SLCO1A2) DMS60RB MT DTP DMS60RB MA Substrate DMS60RB RN Identification of influx transporter for the quinolone antibacterial agent levofloxacin. Mol Pharm. 2007 Jan-Feb;4(1):85-94. DMS60RB RU http://www.ncbi.nlm.nih.gov/pubmed/17274666 DMS60RB DI DMS60RB DMS60RB DN Levofloxacin DMS60RB MI DTUGYRD DMS60RB MN P-glycoprotein 1 (ABCB1) DMS60RB MT DTP DMS60RB MA Substrate DMS60RB RN Mammalian drug efflux transporters of the ATP binding cassette (ABC) family in multidrug resistance: A review of the past decade. Cancer Lett. 2016 Jan 1;370(1):153-64. DMS60RB RU http://www.ncbi.nlm.nih.gov/pubmed/26499806 DMS60RB DI DMS60RB DMS60RB DN Levofloxacin DMS60RB MI TTIXTO3 DMS60RB MN Staphylococcus Topoisomerase IV (Stap-coc parC) DMS60RB MT DTT DMS60RB MA Modulator DMS60RB RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. DMS60RB RU https://www.fda.gov/ DMUV5JB DI DMUV5JB DMUV5JB DN Levomefolic acid DMUV5JB MI DEWSHL5 DMUV5JB MN Vitamin B12 methionine synthase (MTR) DMUV5JB MT DME DMUV5JB MA Metabolism DMUV5JB RN Folic acid and L-5-methyltetrahydrofolate: comparison of clinical pharmacokinetics and pharmacodynamics. Clin Pharmacokinet. 2010 Aug;49(8):535-48. DMUV5JB RU https://www.ncbi.nlm.nih.gov/pubmed/?term=20608755 DMIKFEL DI DMIKFEL DMIKFEL DN Levomepromazine DMIKFEL MI DECB0K3 DMIKFEL MN Cytochrome P450 2D6 (CYP2D6) DMIKFEL MT DME DMIKFEL MA Metabolism DMIKFEL RN Influence of the CYP2D6 isoenzyme in patients treated with venlafaxine for major depressive disorder: clinical and economic consequences. PLoS One. 2014 Nov 4;9(11):e90453. DMIKFEL RU https://www.ncbi.nlm.nih.gov/pubmed/?term=25369508 DMIKFEL DI DMIKFEL DMIKFEL DN Levomepromazine DMIKFEL MI TTEX248 DMIKFEL MN Dopamine D2 receptor (D2R) DMIKFEL MT DTT DMIKFEL MA Modulator DMIKFEL RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. DMIKFEL RU https://www.fda.gov/ DMIKFEL DI DMIKFEL DMIKFEL DN Levomepromazine DMIKFEL MI DTUGYRD DMIKFEL MN P-glycoprotein 1 (ABCB1) DMIKFEL MT DTP DMIKFEL MA Substrate DMIKFEL RN Identification of P-glycoprotein substrates and inhibitors among psychoactive compounds--implications for pharmacokinetics of selected substrates. J Pharm Pharmacol. 2004 Aug;56(8):967-75. DMIKFEL RU http://www.ncbi.nlm.nih.gov/pubmed/15285840 DM06HG5 DI DM06HG5 DM06HG5 DN Levomethadyl Acetate DM06HG5 MI TTKWM86 DM06HG5 MN Opioid receptor mu (MOP) DM06HG5 MT DTT DM06HG5 MA Agonist DM06HG5 RN Methadone-related opioid agonist pharmacotherapy for heroin addiction. History, recent molecular and neurochemical research and future in mainstream medicine. Ann N Y Acad Sci. 2000;909:186-216. DM06HG5 RU https://pubmed.ncbi.nlm.nih.gov/10911931 DM429AE DI DM429AE DM429AE DN Levomethadyl acetate hydrochloride DM429AE MI DEQX145 DM429AE MN Aromatase (CYP19A1) DM429AE MT DME DM429AE MA Metabolism DM429AE RN N-demethylation of levo-alpha-acetylmethadol by human placental aromatase. Biochem Pharmacol. 2004 Mar 1;67(5):885-92. DM429AE RU https://www.ncbi.nlm.nih.gov/pubmed/?term=15104241 DM429AE DI DM429AE DM429AE DN Levomethadyl acetate hydrochloride DM429AE MI DE4LYSA DM429AE MN Cytochrome P450 3A4 (CYP3A4) DM429AE MT DME DM429AE MA Metabolism DM429AE RN Paradoxical role of cytochrome P450 3A in the bioactivation and clinical effects of levo-alpha-acetylmethadol: importance of clinical investigations to validate in vitro drug metabolism studies. Clin Pharmacokinet. 2005;44(7):731-51. DM429AE RU https://www.ncbi.nlm.nih.gov/pubmed/?term=15966756 DM429AE DI DM429AE DM429AE DN Levomethadyl acetate hydrochloride DM429AE MI DEIBDNY DM429AE MN Cytochrome P450 3A5 (CYP3A5) DM429AE MT DME DM429AE MA Metabolism DM429AE RN Drug Interactions Flockhart Table DM429AE RU https://drug-interactions.medicine.iu.edu/Main-Table.aspx DM429AE DI DM429AE DM429AE DN Levomethadyl acetate hydrochloride DM429AE MI DERD86B DM429AE MN Cytochrome P450 3A7 (CYP3A7) DM429AE MT DME DM429AE MA Metabolism DM429AE RN Drug Interactions Flockhart Table DM429AE RU https://drug-interactions.medicine.iu.edu/Main-Table.aspx DMV26S8 DI DMV26S8 DMV26S8 DN Levomilnacipran DMV26S8 MI DES5XRU DMV26S8 MN Cytochrome P450 2C8 (CYP2C8) DMV26S8 MT DME DMV26S8 MA Metabolism DMV26S8 RN The role of levomilnacipran in the management of major depressive disorder: a comprehensive review. Curr Neuropharmacol. 2016;14(2):191-9. DMV26S8 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=26572745 DMV26S8 DI DMV26S8 DMV26S8 DN Levomilnacipran DMV26S8 MI TTAWNKZ DMV26S8 MN Norepinephrine transporter (NET) DMV26S8 MT DTT DMV26S8 MA Modulator DMV26S8 RN Hughes B: 2009 FDA drug approvals. Nat Rev Drug Discov. 2010 Feb;9(2):89-92. DMV26S8 RU https://pubmed.ncbi.nlm.nih.gov/20118952 DMV26S8 DI DMV26S8 DMV26S8 DN Levomilnacipran DMV26S8 MI DTUGYRD DMV26S8 MN P-glycoprotein 1 (ABCB1) DMV26S8 MT DTP DMV26S8 MA Substrate DMV26S8 RN P-glycoprotein differentially affects escitalopram, levomilnacipran, vilazodone and vortioxetine transport at the mouse blood-brain barrier inivo. Neuropharmacology. 2016 Apr;103:104-11. DMV26S8 RU http://www.ncbi.nlm.nih.gov/pubmed/26700248 DMV26S8 DI DMV26S8 DMV26S8 DN Levomilnacipran DMV26S8 MI TT3ROYC DMV26S8 MN Serotonin transporter (SERT) DMV26S8 MT DTT DMV26S8 MA Modulator DMV26S8 RN Hughes B: 2009 FDA drug approvals. Nat Rev Drug Discov. 2010 Feb;9(2):89-92. DMV26S8 RU https://pubmed.ncbi.nlm.nih.gov/20118952 DM1DP7T DI DM1DP7T DM1DP7T DN Levonorgestrel DM1DP7T MI TTUV8G9 DM1DP7T MN Progesterone receptor (PGR) DM1DP7T MT DTT DM1DP7T MA Binder DM1DP7T RN Met909 plays a key role in the activation of the progesterone receptor and also in the high potency of 13-ethyl progestins. Mol Pharmacol. 2009 Jun;75(6):1317-24. DM1DP7T RU https://pubmed.ncbi.nlm.nih.gov/19289570 DMECB4H DI DMECB4H DMECB4H DN Levopropoxyphene Napsylate Anhydrous DMECB4H MI TT35UGH DMECB4H MN Neuronal acetylcholine receptor alpha-3/beta-4 (CHRNA3/B4) DMECB4H MT DTT DMECB4H MA Modulator DMECB4H RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. DMECB4H RU https://www.fda.gov/ DMECB4H DI DMECB4H DMECB4H DN Levopropoxyphene Napsylate Anhydrous DMECB4H MI TTKWM86 DMECB4H MN Opioid receptor mu (MOP) DMECB4H MT DTT DMECB4H MA Modulator DMECB4H RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. DMECB4H RU https://www.fda.gov/ DM2XVNI DI DM2XVNI DM2XVNI DN Levormeloxifene DM2XVNI MI TTZAYWL DM2XVNI MN Estrogen receptor (ESR) DM2XVNI MT DTT DM2XVNI MA Modulator DM2XVNI RN Centchroman, a selective estrogen receptor modulator, as a contraceptive and for the management of hormone-related clinical disorders. Med Res Rev. 2001 Jul;21(4):302-47. DM2XVNI RU https://pubmed.ncbi.nlm.nih.gov/11410933 DMGS80V DI DMGS80V DMGS80V DN Levorphanol DMGS80V MI TT9IK2Z DMGS80V MN N-methyl-D-aspartate receptor (NMDAR) DMGS80V MT DTT DMGS80V MA Antagonist DMGS80V RN Neuroprotective agents for the treatment of acute ischemic stroke. Curr Neurol Neurosci Rep. 2003 Jan;3(1):9-20. DMGS80V RU https://pubmed.ncbi.nlm.nih.gov/12507405 DMGS80V DI DMGS80V DMGS80V DN Levorphanol DMGS80V MI TTN4QDT DMGS80V MN Opioid receptor (OPR) DMGS80V MT DTT DMGS80V MA Agonist DMGS80V RN Comparison of the effects of dextromethorphan, dextrorphan, and levorphanol on the hypothalamo-pituitary-adrenal axis. J Pharmacol Exp Ther. 2004 May;309(2):515-22. DMGS80V RU https://pubmed.ncbi.nlm.nih.gov/14742749 DMKBOS2 DI DMKBOS2 DMKBOS2 DN Levosimendan DMKBOS2 MI TT8RDXP DMKBOS2 MN Troponin C (TN-C) DMKBOS2 MT DTT DMKBOS2 MA Stimulator DMKBOS2 RN Timing of levosimendan in cardiac surgery. Anadolu Kardiyol Derg. 2009 Jun;9(3):223-30. DMKBOS2 RU https://pubmed.ncbi.nlm.nih.gov/19520657 DMHN027 DI DMHN027 DMHN027 DN Levothyroxine DMHN027 MI DE4LYSA DMHN027 MN Cytochrome P450 3A4 (CYP3A4) DMHN027 MT DME DMHN027 MA Metabolism DMHN027 RN [Metabolic interaction between psychopharmaceuticals. Probable cause of exacerbation of hypothyroidism according to a case report]. Lakartidningen. 2002 Jun 20;99(25):2854-6. DMHN027 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=12143142 DMHN027 DI DMHN027 DMHN027 DN Levothyroxine DMHN027 MI DTE2B1D DMHN027 MN Organic anion transporting polypeptide 1A2 (SLCO1A2) DMHN027 MT DTP DMHN027 MA Substrate DMHN027 RN Identification of thyroid hormone transporters in humans: different molecules are involved in a tissue-specific manner. Endocrinology. 2001 May;142(5):2005-12. DMHN027 RU http://www.ncbi.nlm.nih.gov/pubmed/11316767 DMHN027 DI DMHN027 DMHN027 DN Levothyroxine DMHN027 MI DT3D8F0 DMHN027 MN Organic anion transporting polypeptide 1B1 (SLCO1B1) DMHN027 MT DTP DMHN027 MA Substrate DMHN027 RN Identification of a novel gene family encoding human liver-specific organic anion transporter LST-1. J Biol Chem. 1999 Jun 11;274(24):17159-63. DMHN027 RU http://www.ncbi.nlm.nih.gov/pubmed/10358072 DMHN027 DI DMHN027 DMHN027 DN Levothyroxine DMHN027 MI DTPYCQ4 DMHN027 MN Organic anion transporting polypeptide 1C1 (SLCO1C1) DMHN027 MT DTP DMHN027 MA Substrate DMHN027 RN Identification of a novel human organic anion transporting polypeptide as a high affinity thyroxine transporter. Mol Endocrinol. 2002 Oct;16(10):2283-96. DMHN027 RU http://www.ncbi.nlm.nih.gov/pubmed/12351693 DMHN027 DI DMHN027 DMHN027 DN Levothyroxine DMHN027 MI TTTSEPU DMHN027 MN Thyroid hormone receptor alpha (THRA) DMHN027 MT DTT DMHN027 MA Antagonist DMHN027 RN Thyroid hormone resistance and pituitary enlargement after thyroid ablation in a woman on levothyroxine treatment. Thyroid. 2008 Oct;18(10):1119-23. DMHN027 RU https://pubmed.ncbi.nlm.nih.gov/18816177 DMHN027 DI DMHN027 DMHN027 DN Levothyroxine DMHN027 MI DEYGVN4 DMHN027 MN UDP-glucuronosyltransferase 1A1 (UGT1A1) DMHN027 MT DME DMHN027 MA Metabolism DMHN027 RN Drug-drug interactions for UDP-glucuronosyltransferase substrates: a pharmacokinetic explanation for typically observed low exposure (AUCi/AUC) ratios. Drug Metab Dispos. 2004 Nov;32(11):1201-8. DMHN027 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=15304429 DM4PUDW DI DM4PUDW DM4PUDW DN L-glutamic acid DM4PUDW MI DT85HYR DM4PUDW MN Calcium-binding mitochondrial carrier protein Aralar1 (SLC25A12) DM4PUDW MT DTP DM4PUDW MA Substrate DM4PUDW RN Mitochondrial Aspartate/Glutamate Carrier SLC25A12 and Autism Spectrum Disorder: a Meta-Analysis. Mol Neurobiol. 2016 Apr;53(3):1579-1588. DM4PUDW RU http://www.ncbi.nlm.nih.gov/pubmed/25663199 DM4PUDW DI DM4PUDW DM4PUDW DN L-glutamic acid DM4PUDW MI DTDSYAQ DM4PUDW MN Calcium-binding mitochondrial carrier protein Aralar2 (SLC25A13) DM4PUDW MT DTP DM4PUDW MA Substrate DM4PUDW RN Epigenetic upregulation and functional role of the mitochondrial aspartate/glutamate carrier isoform 1 in hepatocellular carcinoma. Biochim Biophys Acta Mol Basis Dis. 2019 Jan;1865(1):38-47. DM4PUDW RU http://www.ncbi.nlm.nih.gov/pubmed/30321589 DM4PUDW DI DM4PUDW DM4PUDW DN L-glutamic acid DM4PUDW MI DTKLMH6 DM4PUDW MN Cystine/glutamate transporter (SLC7A11) DM4PUDW MT DTP DM4PUDW MA Substrate DM4PUDW RN The glutamate/cystine antiporter SLC7A11/xCT enhances cancer cell dependency on glucose by exporting glutamate. J Biol Chem. 2017 Aug 25;292(34):14240-14249. DM4PUDW RU http://www.ncbi.nlm.nih.gov/pubmed/28630042 DM4PUDW DI DM4PUDW DM4PUDW DN L-glutamic acid DM4PUDW MI DT9U216 DM4PUDW MN Excitatory amino acid transporter 1 (SLC1A3) DM4PUDW MT DTP DM4PUDW MA Substrate DM4PUDW RN The SLC1 high-affinity glutamate and neutral amino acid transporter family. Mol Aspects Med. 2013 Apr-Jun;34(2-3):108-20. DM4PUDW RU http://www.ncbi.nlm.nih.gov/pubmed/23506861 DM4PUDW DI DM4PUDW DM4PUDW DN L-glutamic acid DM4PUDW MI DT0VAI5 DM4PUDW MN Excitatory amino acid transporter 2 (SLC1A2) DM4PUDW MT DTP DM4PUDW MA Substrate DM4PUDW RN EAAT2 (GLT-1; slc1a2) glutamate transporters reconstituted in liposomes argues against heteroexchange being substantially faster than net uptake. J Neurosci. 2014 Oct 1;34(40):13472-85. DM4PUDW RU http://www.ncbi.nlm.nih.gov/pubmed/25274824 DM4PUDW DI DM4PUDW DM4PUDW DN L-glutamic acid DM4PUDW MI DTJIRMD DM4PUDW MN Excitatory amino acid transporter 3 (SLC1A1) DM4PUDW MT DTP DM4PUDW MA Substrate DM4PUDW RN Loss-of-function mutations in the glutamate transporter SLC1A1 cause human dicarboxylic aminoaciduria. J Clin Invest. 2011 Jan;121(1):446-53. DM4PUDW RU http://www.ncbi.nlm.nih.gov/pubmed/21123949 DM4PUDW DI DM4PUDW DM4PUDW DN L-glutamic acid DM4PUDW MI DTV2AOB DM4PUDW MN Excitatory amino acid transporter 4 (SLC1A6) DM4PUDW MT DTP DM4PUDW MA Substrate DM4PUDW RN The SLC1 high-affinity glutamate and neutral amino acid transporter family. Mol Aspects Med. 2013 Apr-Jun;34(2-3):108-20. DM4PUDW RU http://www.ncbi.nlm.nih.gov/pubmed/23506861 DM4PUDW DI DM4PUDW DM4PUDW DN L-glutamic acid DM4PUDW MI DTBGZ8H DM4PUDW MN Excitatory amino acid transporter 5 (SLC1A7) DM4PUDW MT DTP DM4PUDW MA Substrate DM4PUDW RN The SLC1 high-affinity glutamate and neutral amino acid transporter family. Mol Aspects Med. 2013 Apr-Jun;34(2-3):108-20. DM4PUDW RU http://www.ncbi.nlm.nih.gov/pubmed/23506861 DM4PUDW DI DM4PUDW DM4PUDW DN L-glutamic acid DM4PUDW MI DTJCWP8 DM4PUDW MN Mitochondrial glutamate carrier 1 (SLC25A22) DM4PUDW MT DTP DM4PUDW MA Substrate DM4PUDW RN Impaired mitochondrial glutamate transport in autosomal recessive neonatal myoclonic epilepsy. Am J Hum Genet. 2005 Feb;76(2):334-9. DM4PUDW RU http://www.ncbi.nlm.nih.gov/pubmed/15592994 DM4PUDW DI DM4PUDW DM4PUDW DN L-glutamic acid DM4PUDW MI DT3VZJO DM4PUDW MN Mitochondrial glutamate carrier 2 (SLC25A18) DM4PUDW MT DTP DM4PUDW MA Substrate DM4PUDW RN The ABCs of membrane transporters in health and disease (SLC series): Introduction. Molecular Aspects of Medicine, 2013, 34(2-3):95-107. (GeneName=SLC25A18) DM4PUDW RU http://slc.bioparadigms.org/protein?GeneName=SLC25A18 DM4PUDW DI DM4PUDW DM4PUDW DN L-glutamic acid DM4PUDW MI TT9IK2Z DM4PUDW MN N-methyl-D-aspartate receptor (NMDAR) DM4PUDW MT DTT DM4PUDW MA Antagonist DM4PUDW RN Altered expression of genes involved in GABAergic transmission and neuromodulation of granule cell activity in the cerebellum of schizophrenia pati... Am J Psychiatry. 2008 Dec;165(12):1594-603. DM4PUDW RU https://pubmed.ncbi.nlm.nih.gov/18923069 DM4PUDW DI DM4PUDW DM4PUDW DN L-glutamic acid DM4PUDW MI DT06JWZ DM4PUDW MN Organic anion transporter 4 (SLC22A11) DM4PUDW MT DTP DM4PUDW MA Substrate DM4PUDW RN The role of the intracellular glutamate gradient in driving organic anion transporter function. DM4PUDW RU http://www.physoc.org/proceedings/abstract/Proc%20Physiol%20Soc%2034C12 DM4PUDW DI DM4PUDW DM4PUDW DN L-glutamic acid DM4PUDW MI DTPFTEQ DM4PUDW MN Organic anion transporting polypeptide 2B1 (SLCO2B1) DM4PUDW MT DTP DM4PUDW MA Substrate DM4PUDW RN The Transporter Classification Database (TCDB): recent advances. Nucleic Acids Res. 2016 Jan 4;44(D1):D372-9. (ID: 2.A.60.1.20) DM4PUDW RU http://www.tcdb.org/search/result.php?tc=2.A.60.1.20 DM4PUDW DI DM4PUDW DM4PUDW DN L-glutamic acid DM4PUDW MI DT38SZL DM4PUDW MN Organic cation transporter-like 3 (SLC22A13) DM4PUDW MT DTP DM4PUDW MA Substrate DM4PUDW RN SLC22A13 catalyses unidirectional efflux of aspartate and glutamate at the basolateral membrane of type A intercalated cells in the renal collecting duct. Biochem J. 2014 Jan 15;457(2):243-51. DM4PUDW RU http://www.ncbi.nlm.nih.gov/pubmed/24147638 DM4PUDW DI DM4PUDW DM4PUDW DN L-glutamic acid DM4PUDW MI DT2LGOY DM4PUDW MN Putative sodium-coupled neutral amino acid transporter 10 (SLC38A10) DM4PUDW MT DTP DM4PUDW MA Substrate DM4PUDW RN The neuronal and astrocytic protein SLC38A10 transports glutamine, glutamate, and aspartate, suggesting a role in neurotransmission. FEBS Open Bio. 2017 Apr 26;7(6):730-746. DM4PUDW RU http://www.ncbi.nlm.nih.gov/pubmed/28593130 DM4PUDW DI DM4PUDW DM4PUDW DN L-glutamic acid DM4PUDW MI DT0UQDA DM4PUDW MN Putative sodium-coupled neutral amino acid transporter 8 (SLC38A8) DM4PUDW MT DTP DM4PUDW MA Substrate DM4PUDW RN Structural modeling of a novel SLC38A8 mutation that causes foveal hypoplasia. Mol Genet Genomic Med. 2017 Feb 26;5(3):202-209. DM4PUDW RU http://www.ncbi.nlm.nih.gov/pubmed/28546991 DM4PUDW DI DM4PUDW DM4PUDW DN L-glutamic acid DM4PUDW MI DTMWE5P DM4PUDW MN Sodium-independent aspartate/glutamate transporter 1 (SLC7A13) DM4PUDW MT DTP DM4PUDW MA Substrate DM4PUDW RN Novel cystine transporter in renal proximal tubule identified as a missing partner of cystinuria-related plasma membrane protein rBAT/SLC3A1. Proc Natl Acad Sci U S A. 2016 Jan 19;113(3):775-80. DM4PUDW RU http://www.ncbi.nlm.nih.gov/pubmed/26739563 DM4PUDW DI DM4PUDW DM4PUDW DN L-glutamic acid DM4PUDW MI DTNK0FR DM4PUDW MN Vesicular glutamate transporter 1 (SLC17A7) DM4PUDW MT DTP DM4PUDW MA Substrate DM4PUDW RN Molecular pharmacology of glutamate transporters, EAATs and VGLUTs. Brain Res Brain Res Rev. 2004 Jul;45(3):250-65. DM4PUDW RU http://www.ncbi.nlm.nih.gov/pubmed/15210307 DM4PUDW DI DM4PUDW DM4PUDW DN L-glutamic acid DM4PUDW MI DT5LHCR DM4PUDW MN Vesicular glutamate transporter 2 (SLC17A6) DM4PUDW MT DTP DM4PUDW MA Substrate DM4PUDW RN Molecular pharmacology of glutamate transporters, EAATs and VGLUTs. Brain Res Brain Res Rev. 2004 Jul;45(3):250-65. DM4PUDW RU http://www.ncbi.nlm.nih.gov/pubmed/15210307 DM4PUDW DI DM4PUDW DM4PUDW DN L-glutamic acid DM4PUDW MI DTAGDH7 DM4PUDW MN Vesicular glutamate transporter 3 (SLC17A8) DM4PUDW MT DTP DM4PUDW MA Substrate DM4PUDW RN Molecular pharmacology of glutamate transporters, EAATs and VGLUTs. Brain Res Brain Res Rev. 2004 Jul;45(3):250-65. DM4PUDW RU http://www.ncbi.nlm.nih.gov/pubmed/15210307 DM69G8X DI DM69G8X DM69G8X DN L-glutamine DM69G8X MI DTW7AE3 DM69G8X MN Alanine/serine/cysteine/threonine transporter 2 (SLC1A5) DM69G8X MT DTP DM69G8X MA Substrate DM69G8X RN High-affinity glutamate transporter GLAST/EAAT1 regulates cell surface expression of glutamine/neutral amino acid transporter ASCT2 in human fetal astrocytes. Neurochem Int. 2006 May-Jun;48(6-7):611-5. DM69G8X RU http://www.ncbi.nlm.nih.gov/pubmed/16516348 DM69G8X DI DM69G8X DM69G8X DN L-glutamine DM69G8X MI DT48T0N DM69G8X MN L-type amino acid transporter 1 (SLC7A5) DM69G8X MT DTP DM69G8X MA Substrate DM69G8X RN Bidirectional transport of amino acids regulates mTOR and autophagy. Cell. 2009 Feb 6;136(3):521-34. DM69G8X RU http://www.ncbi.nlm.nih.gov/pubmed/19203585 DM69G8X DI DM69G8X DM69G8X DN L-glutamine DM69G8X MI DT2EGUN DM69G8X MN Putative sodium-coupled neutral amino acid transporter 7 (SLC38A7) DM69G8X MT DTP DM69G8X MA Substrate DM69G8X RN Identification of SLC38A7 (SNAT7) protein as a glutamine transporter expressed in neurons. J Biol Chem. 2011 Jun 10;286(23):20500-11. DM69G8X RU http://www.ncbi.nlm.nih.gov/pubmed/21511949 DM69G8X DI DM69G8X DM69G8X DN L-glutamine DM69G8X MI DTD815L DM69G8X MN Sodium-coupled neutral amino acid transporter 1 (SLC38A1) DM69G8X MT DTP DM69G8X MA Substrate DM69G8X RN Identification of SLC38A7 (SNAT7) protein as a glutamine transporter expressed in neurons. J Biol Chem. 2011 Jun 10;286(23):20500-11. DM69G8X RU http://www.ncbi.nlm.nih.gov/pubmed/21511949 DM69G8X DI DM69G8X DM69G8X DN L-glutamine DM69G8X MI DTTWL58 DM69G8X MN Sodium-coupled neutral amino acid transporter 2 (SLC38A2) DM69G8X MT DTP DM69G8X MA Substrate DM69G8X RN Identification of SLC38A7 (SNAT7) protein as a glutamine transporter expressed in neurons. J Biol Chem. 2011 Jun 10;286(23):20500-11. DM69G8X RU http://www.ncbi.nlm.nih.gov/pubmed/21511949 DM69G8X DI DM69G8X DM69G8X DN L-glutamine DM69G8X MI DTKWJH3 DM69G8X MN Sodium-coupled neutral amino acid transporter 3 (SLC38A3) DM69G8X MT DTP DM69G8X MA Substrate DM69G8X RN Identification of SLC38A7 (SNAT7) protein as a glutamine transporter expressed in neurons. J Biol Chem. 2011 Jun 10;286(23):20500-11. DM69G8X RU http://www.ncbi.nlm.nih.gov/pubmed/21511949 DM69G8X DI DM69G8X DM69G8X DN L-glutamine DM69G8X MI DTPJBD5 DM69G8X MN Sodium-coupled neutral amino acid transporter 4 (SLC38A4) DM69G8X MT DTP DM69G8X MA Substrate DM69G8X RN Identification of SLC38A7 (SNAT7) protein as a glutamine transporter expressed in neurons. J Biol Chem. 2011 Jun 10;286(23):20500-11. DM69G8X RU http://www.ncbi.nlm.nih.gov/pubmed/21511949 DM69G8X DI DM69G8X DM69G8X DN L-glutamine DM69G8X MI DTLX28N DM69G8X MN Sodium-coupled neutral amino acid transporter 5 (SLC38A5) DM69G8X MT DTP DM69G8X MA Substrate DM69G8X RN Identification of SLC38A7 (SNAT7) protein as a glutamine transporter expressed in neurons. J Biol Chem. 2011 Jun 10;286(23):20500-11. DM69G8X RU http://www.ncbi.nlm.nih.gov/pubmed/21511949 DMNQXV8 DI DMNQXV8 DMNQXV8 DN LGX818 DMNQXV8 MI DE4LYSA DMNQXV8 MN Cytochrome P450 3A4 (CYP3A4) DMNQXV8 MT DME DMNQXV8 MA Metabolism DMNQXV8 RN Development of encorafenib for BRAF-mutated advanced melanoma. Curr Opin Oncol. 2018 Mar;30(2):125-133. DMNQXV8 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=29356698 DMNQXV8 DI DMNQXV8 DMNQXV8 DN LGX818 DMNQXV8 MI DEGTFWK DMNQXV8 MN Mephenytoin 4-hydroxylase (CYP2C19) DMNQXV8 MT DME DMNQXV8 MA Metabolism DMNQXV8 RN Development of encorafenib for BRAF-mutated advanced melanoma. Curr Opin Oncol. 2018 Mar;30(2):125-133. DMNQXV8 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=29356698 DMNQXV8 DI DMNQXV8 DMNQXV8 DN LGX818 DMNQXV8 MI TTWCGQT DMNQXV8 MN Serine/threonine-protein kinase B-raf (BRAF) DMNQXV8 MT DTT DMNQXV8 MA Modulator DMNQXV8 RN Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41. DMNQXV8 RU https://www.ncbi.nlm.nih.gov/pubmed/15950434 DML4ZOT DI DML4ZOT DML4ZOT DN Lidocaine DML4ZOT MI DEJGDUW DML4ZOT MN Cytochrome P450 1A2 (CYP1A2) DML4ZOT MT DME DML4ZOT MA Metabolism DML4ZOT RN Synthetic and natural compounds that interact with human cytochrome P450 1A2 and implications in drug development. Curr Med Chem. 2009;16(31):4066-218. DML4ZOT RU https://www.ncbi.nlm.nih.gov/pubmed/?term=19754423 DML4ZOT DI DML4ZOT DML4ZOT DN Lidocaine DML4ZOT MI DEJVYAZ DML4ZOT MN Cytochrome P450 2A6 (CYP2A6) DML4ZOT MT DME DML4ZOT MA Metabolism DML4ZOT RN Summary of information on human CYP enzymes: human P450 metabolism data. Drug Metab Rev. 2002 Feb-May;34(1-2):83-448. DML4ZOT RU https://www.ncbi.nlm.nih.gov/pubmed/?term=11996015 DML4ZOT DI DML4ZOT DML4ZOT DN Lidocaine DML4ZOT MI DEPKLMQ DML4ZOT MN Cytochrome P450 2B6 (CYP2B6) DML4ZOT MT DME DML4ZOT MA Metabolism DML4ZOT RN Insights into CYP2B6-mediated drug-drug interactions. Acta Pharm Sin B. 2016 Sep;6(5):413-425. DML4ZOT RU https://www.ncbi.nlm.nih.gov/pubmed/?term=27709010 DML4ZOT DI DML4ZOT DML4ZOT DN Lidocaine DML4ZOT MI DEZMWRE DML4ZOT MN Cytochrome P450 2C18 (CYP2C18) DML4ZOT MT DME DML4ZOT MA Metabolism DML4ZOT RN Summary of information on human CYP enzymes: human P450 metabolism data. Drug Metab Rev. 2002 Feb-May;34(1-2):83-448. DML4ZOT RU https://www.ncbi.nlm.nih.gov/pubmed/?term=11996015 DML4ZOT DI DML4ZOT DML4ZOT DN Lidocaine DML4ZOT MI DES5XRU DML4ZOT MN Cytochrome P450 2C8 (CYP2C8) DML4ZOT MT DME DML4ZOT MA Metabolism DML4ZOT RN Summary of information on human CYP enzymes: human P450 metabolism data. Drug Metab Rev. 2002 Feb-May;34(1-2):83-448. DML4ZOT RU https://www.ncbi.nlm.nih.gov/pubmed/?term=11996015 DML4ZOT DI DML4ZOT DML4ZOT DN Lidocaine DML4ZOT MI DE5IED8 DML4ZOT MN Cytochrome P450 2C9 (CYP2C9) DML4ZOT MT DME DML4ZOT MA Metabolism DML4ZOT RN Summary of information on human CYP enzymes: human P450 metabolism data. Drug Metab Rev. 2002 Feb-May;34(1-2):83-448. DML4ZOT RU https://www.ncbi.nlm.nih.gov/pubmed/?term=11996015 DML4ZOT DI DML4ZOT DML4ZOT DN Lidocaine DML4ZOT MI DECB0K3 DML4ZOT MN Cytochrome P450 2D6 (CYP2D6) DML4ZOT MT DME DML4ZOT MA Metabolism DML4ZOT RN Involvement of CYP1A2 and CYP3A4 in lidocaine N-deethylation and 3-hydroxylation in humans. Drug Metab Dispos. 2000 Aug;28(8):959-65. DML4ZOT RU https://www.ncbi.nlm.nih.gov/pubmed/?term=10901707 DML4ZOT DI DML4ZOT DML4ZOT DN Lidocaine DML4ZOT MI DE4LYSA DML4ZOT MN Cytochrome P450 3A4 (CYP3A4) DML4ZOT MT DME DML4ZOT MA Metabolism DML4ZOT RN Pharmacokinetics of lidocaine hydrochloride metabolized by CYP3A4 in Chinese Han volunteers living at low altitude and in native Han and Tibetan Chinese volunteers living at high altitude. Pharmacology. 2016;97(3-4):107-13. DML4ZOT RU https://www.ncbi.nlm.nih.gov/pubmed/?term=26730802 DML4ZOT DI DML4ZOT DML4ZOT DN Lidocaine DML4ZOT MI DEIBDNY DML4ZOT MN Cytochrome P450 3A5 (CYP3A5) DML4ZOT MT DME DML4ZOT MA Metabolism DML4ZOT RN Drug Interactions Flockhart Table DML4ZOT RU https://drug-interactions.medicine.iu.edu/Main-Table.aspx DML4ZOT DI DML4ZOT DML4ZOT DN Lidocaine DML4ZOT MI DERD86B DML4ZOT MN Cytochrome P450 3A7 (CYP3A7) DML4ZOT MT DME DML4ZOT MA Metabolism DML4ZOT RN Drug Interactions Flockhart Table DML4ZOT RU https://drug-interactions.medicine.iu.edu/Main-Table.aspx DML4ZOT DI DML4ZOT DML4ZOT DN Lidocaine DML4ZOT MI DTUGYRD DML4ZOT MN P-glycoprotein 1 (ABCB1) DML4ZOT MT DTP DML4ZOT MA Substrate DML4ZOT RN Mammalian drug efflux transporters of the ATP binding cassette (ABC) family in multidrug resistance: A review of the past decade. Cancer Lett. 2016 Jan 1;370(1):153-64. DML4ZOT RU http://www.ncbi.nlm.nih.gov/pubmed/26499806 DML4ZOT DI DML4ZOT DML4ZOT DN Lidocaine DML4ZOT MI TTN9VTF DML4ZOT MN Voltage-gated sodium channel alpha Nav1.9 (SCN11A) DML4ZOT MT DTT DML4ZOT MA Blocker DML4ZOT RN Mechanisms of analgesia of intravenous lidocaine. Rev Bras Anestesiol. 2008 May-Jun;58(3):280-6. DML4ZOT RU https://pubmed.ncbi.nlm.nih.gov/19378524 DMV23GL DI DMV23GL DMV23GL DN Lidoflazine DMV23GL MI DE4LYSA DMV23GL MN Cytochrome P450 3A4 (CYP3A4) DMV23GL MT DME DMV23GL MA Metabolism DMV23GL RN Integrated analysis on the physicochemical properties of dihydropyridine calcium channel blockers in grapefruit juice interactions. Curr Pharm Biotechnol. 2012 Jul;13(9):1705-17. DMV23GL RU https://www.ncbi.nlm.nih.gov/pubmed/?term=22039822 DMV23GL DI DMV23GL DMV23GL DN Lidoflazine DMV23GL MI TTRK8B9 DMV23GL MN Sodium channel unspecific (NaC) DMV23GL MT DTT DMV23GL MA Inhibitor DMV23GL RN Synthesis and pharmacological evaluation of phenylacetamides as sodium-channel blockers. J Med Chem. 1994 Jan 21;37(2):268-74. DMV23GL RU https://pubmed.ncbi.nlm.nih.gov/8295214 DMV23GL DI DMV23GL DMV23GL DN Lidoflazine DMV23GL MI TTLXAKE DMV23GL MN Solute carrier family 29 member 1 (SLC29A1) DMV23GL MT DTT DMV23GL MA Inhibitor DMV23GL RN Synthesis, flow cytometric evaluation, and identification of highly potent dipyridamole analogues as equilibrative nucleoside transporter 1 inhibit... J Med Chem. 2007 Aug 9;50(16):3906-20. DMV23GL RU https://pubmed.ncbi.nlm.nih.gov/17636949 DMV23GL DI DMV23GL DMV23GL DN Lidoflazine DMV23GL MI TTAXZ0K DMV23GL MN Voltage-gated sodium channel alpha Nav1.3 (SCN3A) DMV23GL MT DTT DMV23GL MA Inhibitor DMV23GL RN Synthesis and pharmacological evaluation of phenylacetamides as sodium-channel blockers. J Med Chem. 1994 Jan 21;37(2):268-74. DMV23GL RU https://pubmed.ncbi.nlm.nih.gov/8295214 DM4WVC5 DI DM4WVC5 DM4WVC5 DN Lifitegrast DM4WVC5 MI TT48WR6 DM4WVC5 MN Integrin alpha-L (ITGAL) DM4WVC5 MT DTT DM4WVC5 MA Modulator DM4WVC5 RN Corneal inflammation is inhibited by the LFA-1 antagonist, lifitegrast (SAR 1118). J Ocul Pharmacol Ther. 2013 May;29(4):395-402. DM4WVC5 RU https://pubmed.ncbi.nlm.nih.gov/23215542 DM4WVC5 DI DM4WVC5 DM4WVC5 DN Lifitegrast DM4WVC5 MI TTCT6F7 DM4WVC5 MN Intercellular adhesion molecule ICAM-1 (ICAM1) DM4WVC5 MT DTT DM4WVC5 MA Inhibitor DM4WVC5 RN Discovery and Development of Potent LFA-1/ICAM-1 Antagonist SAR 1118 as an Ophthalmic Solution for Treating Dry Eye. ACS Med Chem Lett. 2012 Jan 31;3(3):203-6. DM4WVC5 RU https://pubmed.ncbi.nlm.nih.gov/24900456 DM4WVC5 DI DM4WVC5 DM4WVC5 DN Lifitegrast DM4WVC5 MI DTE2B1D DM4WVC5 MN Organic anion transporting polypeptide 1A2 (SLCO1A2) DM4WVC5 MT DTP DM4WVC5 MA Substrate DM4WVC5 RN Clinical Pharmacology and Biopharmaceutics review(s) DM4WVC5 RU https://www.accessdata.fda.gov/drugsatfda_docs/nda/2016/208073Orig1s000ClinPharmR.pdf DM4WVC5 DI DM4WVC5 DM4WVC5 DN Lifitegrast DM4WVC5 MI DTPFTEQ DM4WVC5 MN Organic anion transporting polypeptide 2B1 (SLCO2B1) DM4WVC5 MT DTP DM4WVC5 MA Substrate DM4WVC5 RN Clinical Pharmacology and Biopharmaceutics review(s) DM4WVC5 RU https://www.accessdata.fda.gov/drugsatfda_docs/nda/2016/208073Orig1s000ClinPharmR.pdf DM4EGV0 DI DM4EGV0 DM4EGV0 DN Linaclotide DM4EGV0 MI TTLDPRG DM4EGV0 MN Guanylyl cyclase C (GUCY2C) DM4EGV0 MT DTT DM4EGV0 MA Activator DM4EGV0 RN Emerging drugs for postoperative ileus. Expert Opin Emerg Drugs. 2007 Nov;12(4):619-26. DM4EGV0 RU https://pubmed.ncbi.nlm.nih.gov/17979603 DMWFJTR DI DMWFJTR DMWFJTR DN Linagliptin DMWFJTR MI TTDIGC1 DMWFJTR MN Dipeptidyl peptidase 4 (DPP-4) DMWFJTR MT DTT DMWFJTR MA Inhibitor DMWFJTR RN Boehringer Ingelheim. Product Development Pipeline. June 2 2009. DMWFJTR RU http://www.boehringer-ingelheim.com/corporate/research/pipeline.asp DMWFJTR DI DMWFJTR DMWFJTR DN Linagliptin DMWFJTR MI DTUGYRD DMWFJTR MN P-glycoprotein 1 (ABCB1) DMWFJTR MT DTP DMWFJTR MA Substrate DMWFJTR RN Tarascon Pocket Pharmacopoeia 2018 Classic Shirt-Pocket Edition. DMWFJTR RU https://books.google.com/books?id=0gBRDwAAQBAJ&pg=PP37&lpg=PP37&dq=Methylergonovine+transporter+uptake+efflex&source=bl&ots=cUTe_ppsmZ&sig=ACfU3U3E_YqrDg0CNEuj8K-7lci47HAnrg&hl=zh-CN&sa=X&ved=2ahUKEwjnj-Dk7d7iAhUsK6YKHd5DBDkQ6AEwEnoECAgQAQ#v=onepage&q&f=false DMVTHER DI DMVTHER DMVTHER DN Lincomycin DMVTHER MI TTUWYEA DMVTHER MN Bacterial 50S ribosomal RNA (Bact 50S rRNA) DMVTHER MT DTT DMVTHER MA Inhibitor DMVTHER RN Specific inhibition of 50S ribosomal subunit formation in Staphylococcus aureus cells by 16-membered macrolide, lincosamide, and streptogramin B antibiotics. Curr Microbiol. 2000 Aug;41(2):126-35. DMVTHER RU https://pubmed.ncbi.nlm.nih.gov/10856379 DMB8CNL DI DMB8CNL DMB8CNL DN Lindane DMB8CNL MI TTAN6JD DMB8CNL MN Glutamate receptor AMPA (GRIA) DMB8CNL MT DTT DMB8CNL MA Antagonist DMB8CNL RN NMDA-induced seizure intensity is enhanced in COX-2 deficient mice. Neurotoxicology. 2008 Nov;29(6):1114-20. DMB8CNL RU https://pubmed.ncbi.nlm.nih.gov/18834901 DMGFPU2 DI DMGFPU2 DMGFPU2 DN Linezolid DMGFPU2 MI TTLFGBV DMGFPU2 MN Bacterial 23S ribosomal RNA (Bact 23S rRNA) DMGFPU2 MT DTT DMGFPU2 MA Binder DMGFPU2 RN Genome sequencing of linezolid-resistant Streptococcus pneumoniae mutants reveals novel mechanisms of resistance. Genome Res. 2009 Jul;19(7):1214-23. DMGFPU2 RU https://pubmed.ncbi.nlm.nih.gov/19351617 DM6IR3P DI DM6IR3P DM6IR3P DN Liothyronine DM6IR3P MI DTE2B1D DM6IR3P MN Organic anion transporting polypeptide 1A2 (SLCO1A2) DM6IR3P MT DTP DM6IR3P MA Substrate DM6IR3P RN Identification of thyroid hormone transporters in humans: different molecules are involved in a tissue-specific manner. Endocrinology. 2001 May;142(5):2005-12. DM6IR3P RU http://www.ncbi.nlm.nih.gov/pubmed/11316767 DM6IR3P DI DM6IR3P DM6IR3P DN Liothyronine DM6IR3P MI DT3D8F0 DM6IR3P MN Organic anion transporting polypeptide 1B1 (SLCO1B1) DM6IR3P MT DTP DM6IR3P MA Substrate DM6IR3P RN Identification of a novel gene family encoding human liver-specific organic anion transporter LST-1. J Biol Chem. 1999 Jun 11;274(24):17159-63. DM6IR3P RU http://www.ncbi.nlm.nih.gov/pubmed/10358072 DM6IR3P DI DM6IR3P DM6IR3P DN Liothyronine DM6IR3P MI DT9C1TS DM6IR3P MN Organic anion transporting polypeptide 1B3 (SLCO1B3) DM6IR3P MT DTP DM6IR3P MA Substrate DM6IR3P RN LST-2, a human liver-specific organic anion transporter, determines methotrexate sensitivity in gastrointestinal cancers. Gastroenterology. 2001 Jun;120(7):1689-99. DM6IR3P RU http://www.ncbi.nlm.nih.gov/pubmed/11375950 DM6IR3P DI DM6IR3P DM6IR3P DN Liothyronine DM6IR3P MI DTPYCQ4 DM6IR3P MN Organic anion transporting polypeptide 1C1 (SLCO1C1) DM6IR3P MT DTP DM6IR3P MA Substrate DM6IR3P RN Involvement of multispecific organic anion transporter, Oatp14 (Slc21a14), in the transport of thyroxine across the blood-brain barrier. Endocrinology. 2004 Sep;145(9):4384-91. DM6IR3P RU http://www.ncbi.nlm.nih.gov/pubmed/15166123 DM6IR3P DI DM6IR3P DM6IR3P DN Liothyronine DM6IR3P MI DT8H2IC DM6IR3P MN Organic anion transporting polypeptide 4A1 (SLCO4A1) DM6IR3P MT DTP DM6IR3P MA Substrate DM6IR3P RN Isolation and characterization of a digoxin transporter and its rat homologue expressed in the kidney. Proc Natl Acad Sci U S A. 2004 Mar 9;101(10):3569-74. DM6IR3P RU http://www.ncbi.nlm.nih.gov/pubmed/14993604 DM6IR3P DI DM6IR3P DM6IR3P DN Liothyronine DM6IR3P MI DTY0QMU DM6IR3P MN Organic anion transporting polypeptide 4C1 (SLCO4C1) DM6IR3P MT DTP DM6IR3P MA Substrate DM6IR3P RN Isolation and characterization of a digoxin transporter and its rat homologue expressed in the kidney. Proc Natl Acad Sci U S A. 2004 Mar 9;101(10):3569-74. DM6IR3P RU http://www.ncbi.nlm.nih.gov/pubmed/14993604 DM6IR3P DI DM6IR3P DM6IR3P DN Liothyronine DM6IR3P MI DT56EKP DM6IR3P MN Sodium/taurocholate cotransporting polypeptide (SLC10A1) DM6IR3P MT DTP DM6IR3P MA Substrate DM6IR3P RN Identification of thyroid hormone transporters. Biochem Biophys Res Commun. 1999 Jan 19;254(2):497-501. DM6IR3P RU http://www.ncbi.nlm.nih.gov/pubmed/9918867 DM6IR3P DI DM6IR3P DM6IR3P DN Liothyronine DM6IR3P MI DEYWLRK DM6IR3P MN Sulfotransferase 1A1 (SULT1A1) DM6IR3P MT DME DM6IR3P MA Metabolism DM6IR3P RN Characterization of human liver thermostable phenol sulfotransferase (SULT1A1) allozymes with 3,3',5-triiodothyronine as the substrate. J Endocrinol. 2001 Dec;171(3):525-32. DM6IR3P RU https://www.ncbi.nlm.nih.gov/pubmed/?term=11739018 DM6IR3P DI DM6IR3P DM6IR3P DN Liothyronine DM6IR3P MI TTTSEPU DM6IR3P MN Thyroid hormone receptor alpha (THRA) DM6IR3P MT DTT DM6IR3P MA Antagonist DM6IR3P RN Evaluation of thyroid hormone action in a case of generalized resistance to thyroid hormone with chronic thyroiditis: discovery of a novel heterozy... Endocr J. 2007 Dec;54(5):727-32. DM6IR3P RU https://pubmed.ncbi.nlm.nih.gov/17827792 DM6IR3P DI DM6IR3P DM6IR3P DN Liothyronine DM6IR3P MI DEYGVN4 DM6IR3P MN UDP-glucuronosyltransferase 1A1 (UGT1A1) DM6IR3P MT DME DM6IR3P MA Metabolism DM6IR3P RN FDA Label of Liothyronine sodium. The 2020 official website of the U.S. Food and Drug Administration. DM6IR3P RU https://www.accessdata.fda.gov/drugsatfda_docs/label/2018/010379s054lbl.pdf DMSTXWR DI DMSTXWR DMSTXWR DN Liotrix DMSTXWR MI DE4LYSA DMSTXWR MN Cytochrome P450 3A4 (CYP3A4) DMSTXWR MT DME DMSTXWR MA Metabolism DMSTXWR RN A basic conceptual and practical overview of interactions with highly prescribed drugs. Can J Clin Pharmacol. 2002 Winter;9(4):191-8. DMSTXWR RU https://www.ncbi.nlm.nih.gov/pubmed/?term=12584577 DM3FXPS DI DM3FXPS DM3FXPS DN Liraglutide DM3FXPS MI DEKZQY6 DM3FXPS MN Dipeptidyl peptidase IV (DPP4) DM3FXPS MT DME DM3FXPS MA Metabolism DM3FXPS RN Metabolism and excretion of the once-daily human glucagon-like peptide-1 analog liraglutide in healthy male subjects and its in vitro degradation by dipeptidyl peptidase IV and neutral endopeptidase. Drug Metab Dispos. 2010 Nov;38(11):1944-53. DM3FXPS RU https://www.ncbi.nlm.nih.gov/pubmed/?term=20709939 DM3FXPS DI DM3FXPS DM3FXPS DN Liraglutide DM3FXPS MI TTVIMDE DM3FXPS MN Glucagon-like peptide 1 receptor (GLP1R) DM3FXPS MT DTT DM3FXPS MA Agonist DM3FXPS RN Emerging drugs for obesity: linking novel biological mechanisms to pharmaceutical pipelines. Expert Opin Emerg Drugs. 2005 Aug;10(3):643-60. DM3FXPS RU https://pubmed.ncbi.nlm.nih.gov/16083333 DM3FXPS DI DM3FXPS DM3FXPS DN Liraglutide DM3FXPS MI DEVN830 DM3FXPS MN Neprilysin (MME) DM3FXPS MT DME DM3FXPS MA Metabolism DM3FXPS RN Metabolism and excretion of the once-daily human glucagon-like peptide-1 analog liraglutide in healthy male subjects and its in vitro degradation by dipeptidyl peptidase IV and neutral endopeptidase. Drug Metab Dispos. 2010 Nov;38(11):1944-53. DM3FXPS RU https://www.ncbi.nlm.nih.gov/pubmed/?term=20709939 DM6W8V5 DI DM6W8V5 DM6W8V5 DN Lisdexamfetamine DM6W8V5 MI DECB0K3 DM6W8V5 MN Cytochrome P450 2D6 (CYP2D6) DM6W8V5 MT DME DM6W8V5 MA Metabolism DM6W8V5 RN Preclinical pharmacokinetics, pharmacology and toxicology of lisdexamfetamine: a novel d-amphetamine pro-drug. Neuropharmacology. 2014 Dec;87:41-50. DM6W8V5 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=24594478 DM6W8V5 DI DM6W8V5 DM6W8V5 DN Lisdexamfetamine DM6W8V5 MI DT9G7XN DM6W8V5 MN Peptide transporter 1 (SLC15A1) DM6W8V5 MT DTP DM6W8V5 MA Substrate DM6W8V5 RN Absorption of lisdexamfetamine dimesylate and its enzymatic conversion to d-amphetamine. Neuropsychiatr Dis Treat. 2010 Jun 24;6:317-27. DM6W8V5 RU http://www.ncbi.nlm.nih.gov/pubmed/20628632 DM6W8V5 DI DM6W8V5 DM6W8V5 DN Lisdexamfetamine DM6W8V5 MI TTIU98M DM6W8V5 MN Trace amine-associated receptor-1 (TAAR1) DM6W8V5 MT DTT DM6W8V5 MA Modulator DM6W8V5 RN 2007 FDA drug approvals: a year of flux. Nat Rev Drug Discov. 2008 Feb;7(2):107-9. DM6W8V5 RU https://pubmed.ncbi.nlm.nih.gov/18246607 DMUOK4C DI DMUOK4C DMUOK4C DN Lisinopril DMUOK4C MI TTL69WB DMUOK4C MN Angiotensin-converting enzyme (ACE) DMUOK4C MT DTT DMUOK4C MA Inhibitor DMUOK4C RN Involvement of vascular angiotensin II-forming enzymes in the progression of aortic abdominal aneurysms in angiotensin II- infused ApoE-deficient m... J Atheroscler Thromb. 2009 Jun;16(3):164-71. DMUOK4C RU https://pubmed.ncbi.nlm.nih.gov/19556720 DMUOK4C DI DMUOK4C DMUOK4C DN Lisinopril DMUOK4C MI DT9G7XN DMUOK4C MN Peptide transporter 1 (SLC15A1) DMUOK4C MT DTP DMUOK4C MA Substrate DMUOK4C RN Peptide transporter substrate identification during permeability screening in drug discovery: comparison of transfected MDCK-hPepT1 cells to Caco-2 cells. Arch Pharm Res. 2007 Apr;30(4):507-18. DMUOK4C RU https://doi.org/10.1007/BF02980227 DMP45ME DI DMP45ME DMP45ME DN Lisocabtagene maraleucel DMP45ME MI TTW640A DMP45ME MN B-lymphocyte surface antigen B4 (CD19) DMP45ME MT DTT DMP45ME MA CAR-T-Cell-Therapy DMP45ME RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health Human Services. DMP45ME RU https://www.fda.gov/vaccines-blood-biologics/cellular-gene-therapy-products/breyanzi-lisocabtagene-maraleucel DMCME17 DI DMCME17 DMCME17 DN Lisuride DMCME17 MI DECB0K3 DMCME17 MN Cytochrome P450 2D6 (CYP2D6) DMCME17 MT DME DMCME17 MA Metabolism DMCME17 RN Stable expression of human cytochrome P450 3A4 in V79 cells and its application for metabolic profiling of ergot derivatives. Eur J Pharmacol. 1995 Oct 6;293(3):183-90. DMCME17 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=8666035 DMCME17 DI DMCME17 DMCME17 DN Lisuride DMCME17 MI DE4LYSA DMCME17 MN Cytochrome P450 3A4 (CYP3A4) DMCME17 MT DME DMCME17 MA Metabolism DMCME17 RN Stable expression of human cytochrome P450 3A4 in V79 cells and its application for metabolic profiling of ergot derivatives. Eur J Pharmacol. 1995 Oct 6;293(3):183-90. DMCME17 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=8666035 DMCME17 DI DMCME17 DMCME17 DN Lisuride DMCME17 MI TTEX248 DMCME17 MN Dopamine D2 receptor (D2R) DMCME17 MT DTT DMCME17 MA Agonist DMCME17 RN Fibrotic heart-valve reactions to dopamine-agonist treatment in Parkinson's disease. Lancet Neurol. 2007 Sep;6(9):826-9. DMCME17 RU https://pubmed.ncbi.nlm.nih.gov/17706566 DMX9PIA DI DMX9PIA DMX9PIA DN Live attenuated influenza vaccine DMX9PIA MI TT3J5ZI DMX9PIA MN Cell mediated immunity response (CMIR) DMX9PIA MT DTT DMX9PIA RN Flu myths: dispelling the myths associated with live attenuated influenza vaccine. Mayo Clin Proc. 2008 Jan;83(1):77-84. DMX9PIA RU https://pubmed.ncbi.nlm.nih.gov/18174020 DM0QJDC DI DM0QJDC DM0QJDC DN Lixisenatide DM0QJDC MI TTVIMDE DM0QJDC MN Glucagon-like peptide 1 receptor (GLP1R) DM0QJDC MT DTT DM0QJDC MA Modulator DM0QJDC RN GLP-1 receptor agonists for individualized treatment of type 2 diabetes mellitus.Nat Rev Endocrinol.2012 Dec;8(12):728-42. DM0QJDC RU https://www.ncbi.nlm.nih.gov/pubmed/22945360 DMJPD06 DI DMJPD06 DMJPD06 DN Lmw heparin DMJPD06 MI TTCIHJA DMJPD06 MN Coagulation factor Xa (F10) DMJPD06 MT DTT DMJPD06 MA Modulator DMJPD06 RN Natural products as sources of new drugs over the last 25 years. J Nat Prod. 2007 Mar;70(3):461-77. DMJPD06 RU https://pubmed.ncbi.nlm.nih.gov/17309302 DMHY3IP DI DMHY3IP DMHY3IP DN Lobeglitazone DMHY3IP MI DES5XRU DMHY3IP MN Cytochrome P450 2C8 (CYP2C8) DMHY3IP MT DME DMHY3IP MA Metabolism DMHY3IP RN Effects of gemfibrozil, itraconazole, and their combination on the pharmacokinetics of pioglitazone. Clin Pharmacol Ther. 2005 May;77(5):404-14. DMHY3IP RU https://www.ncbi.nlm.nih.gov/pubmed/?term=15900286 DMHY3IP DI DMHY3IP DMHY3IP DN Lobeglitazone DMHY3IP MI DE4LYSA DMHY3IP MN Cytochrome P450 3A4 (CYP3A4) DMHY3IP MT DME DMHY3IP MA Metabolism DMHY3IP RN Lack of the effect of lobeglitazone, a peroxisome proliferator-activated receptor-gamma agonist, on the pharmacokinetics and pharmacodynamics of warfarin. Drug Des Devel Ther. 2015 Mar 2;9:737-43. DMHY3IP RU https://www.ncbi.nlm.nih.gov/pubmed/?term=25767371 DMHY3IP DI DMHY3IP DMHY3IP DN Lobeglitazone DMHY3IP MI TTJ584C DMHY3IP MN Peroxisome proliferator-activated receptor alpha (PPARA) DMHY3IP MT DTT DMHY3IP MA Agonist DMHY3IP RN Tolerability and pharmacokinetics of lobeglitazone, a novel peroxisome proliferator-activated receptor-gamma agonist, after a single oral administration in healthy female subjects. Clin Drug Investig. 2014 Jul;34(7):467-74. DMHY3IP RU https://pubmed.ncbi.nlm.nih.gov/24802657 DMHY3IP DI DMHY3IP DMHY3IP DN Lobeglitazone DMHY3IP MI TTZMAO3 DMHY3IP MN Peroxisome proliferator-activated receptor gamma (PPAR-gamma) DMHY3IP MT DTT DMHY3IP MA Agonist DMHY3IP RN Tolerability and pharmacokinetics of lobeglitazone, a novel peroxisome proliferator-activated receptor-gamma agonist, after a single oral administration in healthy female subjects. Clin Drug Investig. 2014 Jul;34(7):467-74. DMHY3IP RU https://pubmed.ncbi.nlm.nih.gov/24802657 DM1WXA6 DI DM1WXA6 DM1WXA6 DN Lofexidine DM1WXA6 MI TTQ8AFT DM1WXA6 MN Adrenergic receptor Alpha-2 (ADRA2) DM1WXA6 MT DTT DM1WXA6 MA Agonist DM1WXA6 RN Clinical pharmacokinetics of lofexidine, the alpha 2-adrenergic receptor agonist, in opiate addicts plasma using a highly sensitive liquid chromatography tandem mass spectrometric analysis. Am J DrugAlcohol Abuse. 2008;34(5):611-6. DM1WXA6 RU https://pubmed.ncbi.nlm.nih.gov/18821454 DM1WXA6 DI DM1WXA6 DM1WXA6 DN Lofexidine DM1WXA6 MI TTWG9A4 DM1WXA6 MN Adrenergic receptor alpha-2A (ADRA2A) DM1WXA6 MT DTT DM1WXA6 MA Agonist DM1WXA6 RN 2018 FDA drug approvals.Nat Rev Drug Discov. 2019 Feb;18(2):85-89. DM1WXA6 RU https://pubmed.ncbi.nlm.nih.gov/30710142 DM1WXA6 DI DM1WXA6 DM1WXA6 DN Lofexidine DM1WXA6 MI DEJGDUW DM1WXA6 MN Cytochrome P450 1A2 (CYP1A2) DM1WXA6 MT DME DM1WXA6 MA Metabolism DM1WXA6 RN The Drugs.com International Drug Name Database: Lofexidine DM1WXA6 RU https://www.drugs.com/ppa/lofexidine.html DM1WXA6 DI DM1WXA6 DM1WXA6 DN Lofexidine DM1WXA6 MI DECB0K3 DM1WXA6 MN Cytochrome P450 2D6 (CYP2D6) DM1WXA6 MT DME DM1WXA6 MA Metabolism DM1WXA6 RN Advisory committee lofexidine hydrochloride (lucemyratm) briefing document. DM1WXA6 RU https://www.fda.gov/media/111903/download DM1WXA6 DI DM1WXA6 DM1WXA6 DN Lofexidine DM1WXA6 MI DEGTFWK DM1WXA6 MN Mephenytoin 4-hydroxylase (CYP2C19) DM1WXA6 MT DME DM1WXA6 MA Metabolism DM1WXA6 RN Advisory committee lofexidine hydrochloride (lucemyratm) briefing document. DM1WXA6 RU https://www.fda.gov/media/111903/download DMVRH9C DI DMVRH9C DMVRH9C DN Lomefloxacin DMVRH9C MI DEJGDUW DMVRH9C MN Cytochrome P450 1A2 (CYP1A2) DMVRH9C MT DME DMVRH9C MA Metabolism DMVRH9C RN Inhibitory potency of quinolone antibacterial agents against cytochrome P450IA2 activity in vivo and in vitro. Antimicrob Agents Chemother. 1992 May;36(5):942-8. DMVRH9C RU https://www.ncbi.nlm.nih.gov/pubmed/?term=1510417 DMVRH9C DI DMVRH9C DMVRH9C DN Lomefloxacin DMVRH9C MI TT0IHXV DMVRH9C MN DNA topoisomerase II (TOP2) DMVRH9C MT DTT DMVRH9C MA Inhibitor DMVRH9C RN Inhibition of human topoisomerase IIalpha by fluoroquinolones and ultraviolet A irradiation. Toxicol Sci. 2002 Sep;69(1):16-22. DMVRH9C RU https://pubmed.ncbi.nlm.nih.gov/12215656 DMVRH9C DI DMVRH9C DMVRH9C DN Lomefloxacin DMVRH9C MI DTE2B1D DMVRH9C MN Organic anion transporting polypeptide 1A2 (SLCO1A2) DMVRH9C MT DTP DMVRH9C MA Substrate DMVRH9C RN Identification of influx transporter for the quinolone antibacterial agent levofloxacin. Mol Pharm. 2007 Jan-Feb;4(1):85-94. DMVRH9C RU http://www.ncbi.nlm.nih.gov/pubmed/17274666 DME0TC8 DI DME0TC8 DME0TC8 DN Lomerizine DME0TC8 MI DE4LYSA DME0TC8 MN Cytochrome P450 3A4 (CYP3A4) DME0TC8 MT DME DME0TC8 MA Metabolism DME0TC8 RN Integrated analysis on the physicochemical properties of dihydropyridine calcium channel blockers in grapefruit juice interactions. Curr Pharm Biotechnol. 2012 Jul;13(9):1705-17. DME0TC8 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=22039822 DME0TC8 DI DME0TC8 DME0TC8 DN Lomerizine DME0TC8 MI TTRK8B9 DME0TC8 MN Sodium channel unspecific (NaC) DME0TC8 MT DTT DME0TC8 MA Inhibitor DME0TC8 RN Medicinal chemistry of neuronal voltage-gated sodium channel blockers. J Med Chem. 2001 Jan 18;44(2):115-37. DME0TC8 RU https://pubmed.ncbi.nlm.nih.gov/11170622 DME0TC8 DI DME0TC8 DME0TC8 DN Lomerizine DME0TC8 MI TT4FDG6 DME0TC8 MN Voltage-gated calcium channel alpha Cav2.2 (CACNA1B) DME0TC8 MT DTT DME0TC8 MA Inhibitor DME0TC8 RN Synthesis and SAR of novel 2-arylthiazolidinones as selective analgesic N-type calcium channel blockers. Bioorg Med Chem Lett. 2007 Feb 1;17(3):662-7. DME0TC8 RU https://pubmed.ncbi.nlm.nih.gov/17134896 DME0TC8 DI DME0TC8 DME0TC8 DN Lomerizine DME0TC8 MI TTZOVE0 DME0TC8 MN Voltage-gated sodium channel alpha Nav1.5 (SCN5A) DME0TC8 MT DTT DME0TC8 MA Inhibitor DME0TC8 RN Medicinal chemistry of neuronal voltage-gated sodium channel blockers. J Med Chem. 2001 Jan 18;44(2):115-37. DME0TC8 RU https://pubmed.ncbi.nlm.nih.gov/11170622 DMLB4PE DI DMLB4PE DMLB4PE DN Lomitapide mesylate DMLB4PE MI DE4LYSA DMLB4PE MN Cytochrome P450 3A4 (CYP3A4) DMLB4PE MT DME DMLB4PE MA Metabolism DMLB4PE RN Evaluation of the effects of the weak CYP3A inhibitors atorvastatin and ethinyl estradiol/norgestimate on lomitapide pharmacokinetics in healthy subjects. J Clin Pharmacol. 2016 Jan;56(1):47-55. DMLB4PE RU https://www.ncbi.nlm.nih.gov/pubmed/?term=26120010 DMMWSUL DI DMMWSUL DMMWSUL DN Lomustine DMMWSUL MI TTUTN1I DMMWSUL MN Human Deoxyribonucleic acid (hDNA) DMMWSUL MT DTT DMMWSUL MA Inhibitor DMMWSUL RN Synthesis and evaluation of ethylnitrosoureas of substituted naphthalimides as anticancer compounds. Acta Pol Pharm. 2007 Jan-Feb;64(1):27-33. DMMWSUL RU https://pubmed.ncbi.nlm.nih.gov/17665847 DMGM2Z6 DI DMGM2Z6 DMGM2Z6 DN Lonafarnib DMGM2Z6 MI DE4LYSA DMGM2Z6 MN Cytochrome P450 3A4 (CYP3A4) DMGM2Z6 MT DME DMGM2Z6 MA Metabolism DMGM2Z6 RN Identification of human liver cytochrome P450 enzymes responsible for the metabolism of lonafarnib (Sarasar). Drug Metab Dispos. 2006 Apr;34(4):628-35. DMGM2Z6 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=16443667 DMGM2Z6 DI DMGM2Z6 DMGM2Z6 DN Lonafarnib DMGM2Z6 MI DEIBDNY DMGM2Z6 MN Cytochrome P450 3A5 (CYP3A5) DMGM2Z6 MT DME DMGM2Z6 MA Metabolism DMGM2Z6 RN Identification of human liver cytochrome P450 enzymes responsible for the metabolism of lonafarnib (Sarasar). Drug Metab Dispos. 2006 Apr;34(4):628-35. DMGM2Z6 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=16443667 DMGM2Z6 DI DMGM2Z6 DMGM2Z6 DN Lonafarnib DMGM2Z6 MI TTXQKM3 DMGM2Z6 MN Farnesyl protein transferase (Ftase) DMGM2Z6 MT DTT DMGM2Z6 MA Modulator DMGM2Z6 RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health Human Services. 2020 DMGM2Z6 RU https://www.accessdata.fda.gov/drugsatfda_docs/label/2020/213969s000lbl.pdf DMXSVGI DI DMXSVGI DMXSVGI DN Loncastuximab tesirine DMXSVGI MI TTW640A DMXSVGI MN B-lymphocyte surface antigen B4 (CD19) DMXSVGI MT DTT DMXSVGI MA Inhibitor DMXSVGI RN Final results of a phase 1 study of loncastuximab tesirine in relapsed/refractory B-cell non-Hodgkin lymphoma. Blood. 2021 May 13;137(19):2634-2645. DMXSVGI RU https://pubmed.ncbi.nlm.nih.gov/33211842 DMOJZQ9 DI DMOJZQ9 DMOJZQ9 DN Loperamide DMOJZQ9 MI DEPKLMQ DMOJZQ9 MN Cytochrome P450 2B6 (CYP2B6) DMOJZQ9 MT DME DMOJZQ9 MA Metabolism DMOJZQ9 RN Identification of cytochrome P450 isoforms involved in the metabolism of loperamide in human liver microsomes. Eur J Clin Pharmacol. 2004 Oct;60(8):575-81. DMOJZQ9 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=15365656 DMOJZQ9 DI DMOJZQ9 DMOJZQ9 DN Loperamide DMOJZQ9 MI DES5XRU DMOJZQ9 MN Cytochrome P450 2C8 (CYP2C8) DMOJZQ9 MT DME DMOJZQ9 MA Metabolism DMOJZQ9 RN Identification of cytochrome P450 isoforms involved in the metabolism of loperamide in human liver microsomes. Eur J Clin Pharmacol. 2004 Oct;60(8):575-81. DMOJZQ9 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=15365656 DMOJZQ9 DI DMOJZQ9 DMOJZQ9 DN Loperamide DMOJZQ9 MI DECB0K3 DMOJZQ9 MN Cytochrome P450 2D6 (CYP2D6) DMOJZQ9 MT DME DMOJZQ9 MA Metabolism DMOJZQ9 RN Identification of cytochrome P450 isoforms involved in the metabolism of loperamide in human liver microsomes. Eur J Clin Pharmacol. 2004 Oct;60(8):575-81. DMOJZQ9 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=15365656 DMOJZQ9 DI DMOJZQ9 DMOJZQ9 DN Loperamide DMOJZQ9 MI DE4LYSA DMOJZQ9 MN Cytochrome P450 3A4 (CYP3A4) DMOJZQ9 MT DME DMOJZQ9 MA Metabolism DMOJZQ9 RN Loperamide: a pharmacological review. Rev Gastroenterol Disord. 2007;7 Suppl 3:S11-8. DMOJZQ9 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=18192961 DMOJZQ9 DI DMOJZQ9 DMOJZQ9 DN Loperamide DMOJZQ9 MI TT27RFC DMOJZQ9 MN Opioid receptor delta (OPRD1) DMOJZQ9 MT DTT DMOJZQ9 MA Binder DMOJZQ9 RN Loperamide: evidence of interaction with mu and delta opioid receptors. Life Sci. 1983;33 Suppl 1:315-8. DMOJZQ9 RU https://pubmed.ncbi.nlm.nih.gov/6319884 DMOJZQ9 DI DMOJZQ9 DMOJZQ9 DN Loperamide DMOJZQ9 MI DEDPI65 DMOJZQ9 MN Oxygen-insensitive NADPH nitroreductase A (nfsA) DMOJZQ9 MT DME DMOJZQ9 MA Metabolism DMOJZQ9 RN Reduction of the prodrug loperamide oxide to its active drug loperamide in the gut of rats, dogs, and humans. Drug Metab Dispos. 1995 Mar;23(3):354-62. DMOJZQ9 RU https://pubmed.ncbi.nlm.nih.gov/7628301 DMOJZQ9 DI DMOJZQ9 DMOJZQ9 DN Loperamide DMOJZQ9 MI DTUGYRD DMOJZQ9 MN P-glycoprotein 1 (ABCB1) DMOJZQ9 MT DTP DMOJZQ9 MA Substrate DMOJZQ9 RN In vitro P-glycoprotein assays to predict the in vivo interactions of P-glycoprotein with drugs in the central nervous system. Drug Metab Dispos. 2008 Feb;36(2):268-75. DMOJZQ9 RU http://www.ncbi.nlm.nih.gov/pubmed/17962372 DMITQS0 DI DMITQS0 DMITQS0 DN Lopinavir DMITQS0 MI TTLFGBV DMITQS0 MN Bacterial 23S ribosomal RNA (Bact 23S rRNA) DMITQS0 MT DTT DMITQS0 MA Modulator DMITQS0 RN Company report (JMI Laboratories) DMITQS0 RU http://www.jmilabs.com/data/posters/ICAAC2013%5CE-144.pdf DMITQS0 DI DMITQS0 DMITQS0 DN Lopinavir DMITQS0 MI DTI7UX6 DMITQS0 MN Breast cancer resistance protein (ABCG2) DMITQS0 MT DTP DMITQS0 MA Substrate DMITQS0 RN Mammalian drug efflux transporters of the ATP binding cassette (ABC) family in multidrug resistance: A review of the past decade. Cancer Lett. 2016 Jan 1;370(1):153-64. DMITQS0 RU http://www.ncbi.nlm.nih.gov/pubmed/26499806 DMITQS0 DI DMITQS0 DMITQS0 DN Lopinavir DMITQS0 MI DE4LYSA DMITQS0 MN Cytochrome P450 3A4 (CYP3A4) DMITQS0 MT DME DMITQS0 MA Metabolism DMITQS0 RN Synthesis and antiviral activities of the major metabolites of the HIV protease inhibitor ABT-378 (Lopinavir). Bioorg Med Chem Lett. 2001 Jun 4;11(11):1351-3. DMITQS0 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=11378352 DMITQS0 DI DMITQS0 DMITQS0 DN Lopinavir DMITQS0 MI DTSYQGK DMITQS0 MN Multidrug resistance-associated protein 1 (ABCC1) DMITQS0 MT DTP DMITQS0 MA Substrate DMITQS0 RN Inhibition of P-glycoprotein and multidrug resistance-associated proteins modulates the intracellular concentration of lopinavir in cultured CD4 T cells and primary human lymphocytes. J Antimicrob Chemother. 2007 Nov;60(5):987-93. DMITQS0 RU http://www.ncbi.nlm.nih.gov/pubmed/17890284 DMITQS0 DI DMITQS0 DMITQS0 DN Lopinavir DMITQS0 MI DTFI42L DMITQS0 MN Multidrug resistance-associated protein 2 (ABCC2) DMITQS0 MT DTP DMITQS0 MA Substrate DMITQS0 RN Effects of cytochrome P450 3A (CYP3A) and the drug transporters P-glycoprotein (MDR1/ABCB1) and MRP2 (ABCC2) on the pharmacokinetics of lopinavir. Br J Pharmacol. 2010 Jul;160(5):1224-33. DMITQS0 RU http://www.ncbi.nlm.nih.gov/pubmed/20590614 DMITQS0 DI DMITQS0 DMITQS0 DN Lopinavir DMITQS0 MI DT3D8F0 DMITQS0 MN Organic anion transporting polypeptide 1B1 (SLCO1B1) DMITQS0 MT DTP DMITQS0 MA Substrate DMITQS0 RN Organic anion transporting polypeptide 1B1: a genetically polymorphic transporter of major importance for hepatic drug uptake. Pharmacol Rev. 2011 Mar;63(1):157-81. DMITQS0 RU http://www.ncbi.nlm.nih.gov/pubmed/21245207 DMITQS0 DI DMITQS0 DMITQS0 DN Lopinavir DMITQS0 MI DTUGYRD DMITQS0 MN P-glycoprotein 1 (ABCB1) DMITQS0 MT DTP DMITQS0 MA Substrate DMITQS0 RN Effects of cytochrome P450 3A (CYP3A) and the drug transporters P-glycoprotein (MDR1/ABCB1) and MRP2 (ABCC2) on the pharmacokinetics of lopinavir. Br J Pharmacol. 2010 Jul;160(5):1224-33. DMITQS0 RU http://www.ncbi.nlm.nih.gov/pubmed/20590614 DM4L8H3 DI DM4L8H3 DM4L8H3 DN Loracarbef DM4L8H3 MI TTJP4SM DM4L8H3 MN Bacterial Penicillin binding protein (Bact PBP) DM4L8H3 MT DTT DM4L8H3 MA Binder DM4L8H3 RN Amino acid substitutions in mosaic penicillin-binding protein 2 associated with reduced susceptibility to cefixime in clinical isolates of Neisseri... Antimicrob Agents Chemother. 2006 Nov;50(11):3638-45. DM4L8H3 RU https://pubmed.ncbi.nlm.nih.gov/16940068 DMF3AN7 DI DMF3AN7 DMF3AN7 DN Loratadine DMF3AN7 MI DEJGDUW DMF3AN7 MN Cytochrome P450 1A2 (CYP1A2) DMF3AN7 MT DME DMF3AN7 MA Metabolism DMF3AN7 RN Metabolism of loratadine and further characterization of its in vitro metabolites. Drug Metab Lett. 2009 Aug;3(3):162-70. DMF3AN7 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=19702548 DMF3AN7 DI DMF3AN7 DMF3AN7 DN Loratadine DMF3AN7 MI DEPKLMQ DMF3AN7 MN Cytochrome P450 2B6 (CYP2B6) DMF3AN7 MT DME DMF3AN7 MA Metabolism DMF3AN7 RN Metabolism of loratadine and further characterization of its in vitro metabolites. Drug Metab Lett. 2009 Aug;3(3):162-70. DMF3AN7 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=19702548 DMF3AN7 DI DMF3AN7 DMF3AN7 DN Loratadine DMF3AN7 MI DES5XRU DMF3AN7 MN Cytochrome P450 2C8 (CYP2C8) DMF3AN7 MT DME DMF3AN7 MA Metabolism DMF3AN7 RN Role of cytochrome P450 2C8 in drug metabolism and interactions. Pharmacol Rev. 2016 Jan;68(1):168-241. DMF3AN7 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=26721703 DMF3AN7 DI DMF3AN7 DMF3AN7 DN Loratadine DMF3AN7 MI DE5IED8 DMF3AN7 MN Cytochrome P450 2C9 (CYP2C9) DMF3AN7 MT DME DMF3AN7 MA Metabolism DMF3AN7 RN In vitro inhibition of human liver drug metabolizing enzymes by second generation antihistamines. Chem Biol Interact. 1999 Nov 15;123(1):63-79. DMF3AN7 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=10597902 DMF3AN7 DI DMF3AN7 DMF3AN7 DN Loratadine DMF3AN7 MI DECB0K3 DMF3AN7 MN Cytochrome P450 2D6 (CYP2D6) DMF3AN7 MT DME DMF3AN7 MA Metabolism DMF3AN7 RN In vitro characterization of the inhibition profile of loratadine, desloratadine, and 3-OH-desloratadine for five human cytochrome P-450 enzymes. Drug Metab Dispos. 2001 Sep;29(9):1173-5. DMF3AN7 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=11502723 DMF3AN7 DI DMF3AN7 DMF3AN7 DN Loratadine DMF3AN7 MI DE4LYSA DMF3AN7 MN Cytochrome P450 3A4 (CYP3A4) DMF3AN7 MT DME DMF3AN7 MA Metabolism DMF3AN7 RN Summary of information on human CYP enzymes: human P450 metabolism data. Drug Metab Rev. 2002 Feb-May;34(1-2):83-448. DMF3AN7 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=11996015 DMF3AN7 DI DMF3AN7 DMF3AN7 DN Loratadine DMF3AN7 MI DEIBDNY DMF3AN7 MN Cytochrome P450 3A5 (CYP3A5) DMF3AN7 MT DME DMF3AN7 MA Metabolism DMF3AN7 RN Metabolism of loratadine and further characterization of its in vitro metabolites. Drug Metab Lett. 2009 Aug;3(3):162-70. DMF3AN7 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=19702548 DMF3AN7 DI DMF3AN7 DMF3AN7 DN Loratadine DMF3AN7 MI TTTIBOJ DMF3AN7 MN Histamine H1 receptor (H1R) DMF3AN7 MT DTT DMF3AN7 MA Antagonist DMF3AN7 RN Clinical research of Ibudilast on treating the steroid resistant allergic rhinitis. Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2009 Jan;23(2):63-6. DMF3AN7 RU https://pubmed.ncbi.nlm.nih.gov/19452709 DMF3AN7 DI DMF3AN7 DMF3AN7 DN Loratadine DMF3AN7 MI DEGTFWK DMF3AN7 MN Mephenytoin 4-hydroxylase (CYP2C19) DMF3AN7 MT DME DMF3AN7 MA Metabolism DMF3AN7 RN Advances in high-resolution MS and hepatocyte models solve a long-standing metabolism challenge: the loratadine story. Bioanalysis. 2016 Aug;8(16):1645-62. DMF3AN7 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=27460981 DMF3AN7 DI DMF3AN7 DMF3AN7 DN Loratadine DMF3AN7 MI DTUGYRD DMF3AN7 MN P-glycoprotein 1 (ABCB1) DMF3AN7 MT DTP DMF3AN7 MA Substrate DMF3AN7 RN P-glycoprotein limits the brain penetration of nonsedating but not sedating H1-antagonists. Drug Metab Dispos. 2003 Mar;31(3):312-8. DMF3AN7 RU http://www.ncbi.nlm.nih.gov/pubmed/12584158 DM84ZXF DI DM84ZXF DM84ZXF DN Lorazepam DM84ZXF MI TTPTXIN DM84ZXF MN Translocator protein (TSPO) DM84ZXF MT DTT DM84ZXF MA Modulator DM84ZXF RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. DM84ZXF RU https://www.fda.gov/ DM84ZXF DI DM84ZXF DM84ZXF DN Lorazepam DM84ZXF MI DENZ6B1 DM84ZXF MN UDP-glucuronosyltransferase 2B15 (UGT2B15) DM84ZXF MT DME DM84ZXF MA Metabolism DM84ZXF RN Effect of the UGT2B15 genotype on the pharmacokinetics, pharmacodynamics, and drug interactions of intravenous lorazepam in healthy volunteers. Clin Pharmacol Ther. 2005 Jun;77(6):486-94. DM84ZXF RU https://www.ncbi.nlm.nih.gov/pubmed/?term=15961980 DM84ZXF DI DM84ZXF DM84ZXF DN Lorazepam DM84ZXF MI DEB3CV1 DM84ZXF MN UDP-glucuronosyltransferase 2B7 (UGT2B7) DM84ZXF MT DME DM84ZXF MA Metabolism DM84ZXF RN Pharmacokinetic and pharmacodynamic interaction of lorazepam and valproic acid in relation to UGT2B7 genetic polymorphism in healthy subjects. Clin Pharmacol Ther. 2008 Apr;83(4):595-600. DM84ZXF RU https://www.ncbi.nlm.nih.gov/pubmed/?term=17687269 DMG6OYJ DI DMG6OYJ DMG6OYJ DN Lorcaserin DMG6OYJ MI TTWJBZ5 DMG6OYJ MN 5-HT 2C receptor (HTR2C) DMG6OYJ MT DTT DMG6OYJ MA Agonist DMG6OYJ RN Anti-obesity drugs. Expert Opin Pharmacother. 2008 Jun;9(8):1339-50. DMG6OYJ RU https://pubmed.ncbi.nlm.nih.gov/18473708 DMG6OYJ DI DMG6OYJ DMG6OYJ DN Lorcaserin DMG6OYJ MI DEJGDUW DMG6OYJ MN Cytochrome P450 1A2 (CYP1A2) DMG6OYJ MT DME DMG6OYJ MA Metabolism DMG6OYJ RN Identification of human cytochrome P450 and flavin-containing monooxygenase enzymes involved in the metabolism of lorcaserin, a novel selective human 5-hydroxytryptamine 2C agonist. Drug Metab Dispos. 2012 Apr;40(4):761-71. DMG6OYJ RU https://www.ncbi.nlm.nih.gov/pubmed/?term=22266842 DMG6OYJ DI DMG6OYJ DMG6OYJ DN Lorcaserin DMG6OYJ MI DEJVYAZ DMG6OYJ MN Cytochrome P450 2A6 (CYP2A6) DMG6OYJ MT DME DMG6OYJ MA Metabolism DMG6OYJ RN Identification of human cytochrome P450 and flavin-containing monooxygenase enzymes involved in the metabolism of lorcaserin, a novel selective human 5-hydroxytryptamine 2C agonist. Drug Metab Dispos. 2012 Apr;40(4):761-71. DMG6OYJ RU https://www.ncbi.nlm.nih.gov/pubmed/?term=22266842 DMG6OYJ DI DMG6OYJ DMG6OYJ DN Lorcaserin DMG6OYJ MI DEPKLMQ DMG6OYJ MN Cytochrome P450 2B6 (CYP2B6) DMG6OYJ MT DME DMG6OYJ MA Metabolism DMG6OYJ RN Identification of human cytochrome P450 and flavin-containing monooxygenase enzymes involved in the metabolism of lorcaserin, a novel selective human 5-hydroxytryptamine 2C agonist. Drug Metab Dispos. 2012 Apr;40(4):761-71. DMG6OYJ RU https://www.ncbi.nlm.nih.gov/pubmed/?term=22266842 DMG6OYJ DI DMG6OYJ DMG6OYJ DN Lorcaserin DMG6OYJ MI DECB0K3 DMG6OYJ MN Cytochrome P450 2D6 (CYP2D6) DMG6OYJ MT DME DMG6OYJ MA Metabolism DMG6OYJ RN Identification of human cytochrome P450 and flavin-containing monooxygenase enzymes involved in the metabolism of lorcaserin, a novel selective human 5-hydroxytryptamine 2C agonist. Drug Metab Dispos. 2012 Apr;40(4):761-71. DMG6OYJ RU https://www.ncbi.nlm.nih.gov/pubmed/?term=22266842 DMG6OYJ DI DMG6OYJ DMG6OYJ DN Lorcaserin DMG6OYJ MI DE4LYSA DMG6OYJ MN Cytochrome P450 3A4 (CYP3A4) DMG6OYJ MT DME DMG6OYJ MA Metabolism DMG6OYJ RN Identification of human cytochrome P450 and flavin-containing monooxygenase enzymes involved in the metabolism of lorcaserin, a novel selective human 5-hydroxytryptamine 2C agonist. Drug Metab Dispos. 2012 Apr;40(4):761-71. DMG6OYJ RU https://www.ncbi.nlm.nih.gov/pubmed/?term=22266842 DMG6OYJ DI DMG6OYJ DMG6OYJ DN Lorcaserin DMG6OYJ MI DEGTFWK DMG6OYJ MN Mephenytoin 4-hydroxylase (CYP2C19) DMG6OYJ MT DME DMG6OYJ MA Metabolism DMG6OYJ RN Identification of human cytochrome P450 and flavin-containing monooxygenase enzymes involved in the metabolism of lorcaserin, a novel selective human 5-hydroxytryptamine 2C agonist. Drug Metab Dispos. 2012 Apr;40(4):761-71. DMG6OYJ RU https://www.ncbi.nlm.nih.gov/pubmed/?term=22266842 DMICDLV DI DMICDLV DMICDLV DN Lorlatinib DMICDLV MI TTPMQSO DMICDLV MN ALK tyrosine kinase receptor (ALK) DMICDLV MT DTT DMICDLV MA Inhibitor DMICDLV RN 2018 FDA drug approvals.Nat Rev Drug Discov. 2019 Feb;18(2):85-89. DMICDLV RU https://pubmed.ncbi.nlm.nih.gov/30710142 DMICDLV DI DMICDLV DMICDLV DN Lorlatinib DMICDLV MI DES5XRU DMICDLV MN Cytochrome P450 2C8 (CYP2C8) DMICDLV MT DME DMICDLV MA Metabolism DMICDLV RN FDA label of Lorlatinib. The 2020 official website of the U.S. Food and Drug Administration. DMICDLV RU https://www.accessdata.fda.gov/drugsatfda_docs/label/2018/210868s000lbl.pdf DMICDLV DI DMICDLV DMICDLV DN Lorlatinib DMICDLV MI DE4LYSA DMICDLV MN Cytochrome P450 3A4 (CYP3A4) DMICDLV MT DME DMICDLV MA Metabolism DMICDLV RN FDA label of Lorlatinib. The 2020 official website of the U.S. Food and Drug Administration. DMICDLV RU https://www.accessdata.fda.gov/drugsatfda_docs/label/2018/210868s000lbl.pdf DMICDLV DI DMICDLV DMICDLV DN Lorlatinib DMICDLV MI DEIBDNY DMICDLV MN Cytochrome P450 3A5 (CYP3A5) DMICDLV MT DME DMICDLV MA Metabolism DMICDLV RN FDA label of Lorlatinib. The 2020 official website of the U.S. Food and Drug Administration. DMICDLV RU https://www.accessdata.fda.gov/drugsatfda_docs/label/2018/210868s000lbl.pdf DMICDLV DI DMICDLV DMICDLV DN Lorlatinib DMICDLV MI DERD86B DMICDLV MN Cytochrome P450 3A7 (CYP3A7) DMICDLV MT DME DMICDLV MA Metabolism DMICDLV RN Product characteristics of Lorviqua. DMICDLV RU https://www.ema.europa.eu/en/documents/product-information/lorviqua-epar-product-information_en.pdf DMICDLV DI DMICDLV DMICDLV DN Lorlatinib DMICDLV MI DEGTFWK DMICDLV MN Mephenytoin 4-hydroxylase (CYP2C19) DMICDLV MT DME DMICDLV MA Metabolism DMICDLV RN FDA label of Lorlatinib. The 2020 official website of the U.S. Food and Drug Administration. DMICDLV RU https://www.accessdata.fda.gov/drugsatfda_docs/label/2018/210868s000lbl.pdf DMICDLV DI DMICDLV DMICDLV DN Lorlatinib DMICDLV MI TTSZ6Y3 DMICDLV MN Proto-oncogene c-Ros (ROS1) DMICDLV MT DTT DMICDLV MA Inhibitor DMICDLV RN 2018 FDA drug approvals.Nat Rev Drug Discov. 2019 Feb;18(2):85-89. DMICDLV RU https://pubmed.ncbi.nlm.nih.gov/30710142 DMICDLV DI DMICDLV DMICDLV DN Lorlatinib DMICDLV MI DEF2WXN DMICDLV MN UDP-glucuronosyltransferase 1A3 (UGT1A3) DMICDLV MT DME DMICDLV MA Metabolism DMICDLV RN FDA label of Lorlatinib. The 2020 official website of the U.S. Food and Drug Administration. DMICDLV RU https://www.accessdata.fda.gov/drugsatfda_docs/label/2018/210868s000lbl.pdf DMICDLV DI DMICDLV DMICDLV DN Lorlatinib DMICDLV MI DELOY3P DMICDLV MN UDP-glucuronosyltransferase 1A4 (UGT1A4) DMICDLV MT DME DMICDLV MA Metabolism DMICDLV RN FDA label of Lorlatinib. The 2020 official website of the U.S. Food and Drug Administration. DMICDLV RU https://www.accessdata.fda.gov/drugsatfda_docs/label/2018/210868s000lbl.pdf DMYZFXN DI DMYZFXN DMYZFXN DN Lornoxicam DMYZFXN MI DE5IED8 DMYZFXN MN Cytochrome P450 2C9 (CYP2C9) DMYZFXN MT DME DMYZFXN MA Metabolism DMYZFXN RN Prediction of pharmacokinetic drug/drug interactions from In vitro data: interactions of the nonsteroidal anti-inflammatory drug lornoxicam with oral anticoagulants. Drug Metab Dispos. 2000 Feb;28(2):161-8. DMYZFXN RU https://www.ncbi.nlm.nih.gov/pubmed/?term=10640513 DMYZFXN DI DMYZFXN DMYZFXN DN Lornoxicam DMYZFXN MI TTK0943 DMYZFXN MN Prostaglandin G/H synthase (COX) DMYZFXN MT DTT DMYZFXN MA Modulator DMYZFXN RN The analgesic NSAID lornoxicam inhibits cyclooxygenase (COX)-1/-2, inducible nitric oxide synthase (iNOS), and the formation of interleukin (IL)-6 in vitro. Inflamm Res. 1999 Jul;48(7):369-79. DMYZFXN RU https://pubmed.ncbi.nlm.nih.gov/10450786 DM72JXH DI DM72JXH DM72JXH DN Losartan DM72JXH MI TT8DBY3 DM72JXH MN Angiotensin II receptor type-1 (AGTR1) DM72JXH MT DTT DM72JXH MA Antagonist DM72JXH RN Radioligand binding assays: application of [(125)I]angiotensin II receptor binding. Methods Mol Biol. 2009;552:131-41. DM72JXH RU https://pubmed.ncbi.nlm.nih.gov/19513646 DM72JXH DI DM72JXH DM72JXH DN Losartan DM72JXH MI DES5XRU DM72JXH MN Cytochrome P450 2C8 (CYP2C8) DM72JXH MT DME DM72JXH MA Metabolism DM72JXH RN Drug-drug interaction between losartan and paclitaxel in human liver microsomes with different CYP2C8 genotypes. Basic Clin Pharmacol Toxicol. 2015 Jun;116(6):493-8. DM72JXH RU https://www.ncbi.nlm.nih.gov/pubmed/?term=25424246 DM72JXH DI DM72JXH DM72JXH DN Losartan DM72JXH MI DE5IED8 DM72JXH MN Cytochrome P450 2C9 (CYP2C9) DM72JXH MT DME DM72JXH MA Metabolism DM72JXH RN Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. DM72JXH RU https://www.ncbi.nlm.nih.gov/pubmed/?term=19515014 DM72JXH DI DM72JXH DM72JXH DN Losartan DM72JXH MI DE4LYSA DM72JXH MN Cytochrome P450 3A4 (CYP3A4) DM72JXH MT DME DM72JXH MA Metabolism DM72JXH RN Summary of information on human CYP enzymes: human P450 metabolism data. Drug Metab Rev. 2002 Feb-May;34(1-2):83-448. DM72JXH RU https://www.ncbi.nlm.nih.gov/pubmed/?term=11996015 DM72JXH DI DM72JXH DM72JXH DN Losartan DM72JXH MI DEIBDNY DM72JXH MN Cytochrome P450 3A5 (CYP3A5) DM72JXH MT DME DM72JXH MA Metabolism DM72JXH RN Summary of information on human CYP enzymes: human P450 metabolism data. Drug Metab Rev. 2002 Feb-May;34(1-2):83-448. DM72JXH RU https://www.ncbi.nlm.nih.gov/pubmed/?term=11996015 DM72JXH DI DM72JXH DM72JXH DN Losartan DM72JXH MI DT9G7XN DM72JXH MN Peptide transporter 1 (SLC15A1) DM72JXH MT DTP DM72JXH MA Substrate DM72JXH RN High-affinity interaction of sartans with H+/peptide transporters. Drug Metab Dispos. 2009 Jan;37(1):143-9. DM72JXH RU http://www.ncbi.nlm.nih.gov/pubmed/18824524 DM72JXH DI DM72JXH DM72JXH DN Losartan DM72JXH MI DTUGYRD DM72JXH MN P-glycoprotein 1 (ABCB1) DM72JXH MT DTP DM72JXH MA Substrate DM72JXH RN Active transport of the angiotensin-II antagonist losartan and its main metabolite EXP 3174 across MDCK-MDR1 and caco-2 cell monolayers. Br J Pharmacol. 2000 Mar;129(6):1235-43. DM72JXH RU http://www.ncbi.nlm.nih.gov/pubmed/10725273 DM72JXH DI DM72JXH DM72JXH DN Losartan DM72JXH MI DEYGVN4 DM72JXH MN UDP-glucuronosyltransferase 1A1 (UGT1A1) DM72JXH MT DME DM72JXH MA Metabolism DM72JXH RN The human UDP-glucuronosyltransferase UGT1A3 is highly selective towards N2 in the tetrazole ring of losartan, candesartan, and zolarsartan. Biochem Pharmacol. 2008 Sep 15;76(6):763-72. DM72JXH RU https://www.ncbi.nlm.nih.gov/pubmed/?term=18674515 DM72JXH DI DM72JXH DM72JXH DN Losartan DM72JXH MI DEL5N6Y DM72JXH MN UDP-glucuronosyltransferase 1A10 (UGT1A10) DM72JXH MT DME DM72JXH MA Metabolism DM72JXH RN Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. DM72JXH RU https://www.ncbi.nlm.nih.gov/pubmed/?term=19515014 DM72JXH DI DM72JXH DM72JXH DN Losartan DM72JXH MI DEF2WXN DM72JXH MN UDP-glucuronosyltransferase 1A3 (UGT1A3) DM72JXH MT DME DM72JXH MA Metabolism DM72JXH RN Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. DM72JXH RU https://www.ncbi.nlm.nih.gov/pubmed/?term=19515014 DM72JXH DI DM72JXH DM72JXH DN Losartan DM72JXH MI DEB3CV1 DM72JXH MN UDP-glucuronosyltransferase 2B7 (UGT2B7) DM72JXH MT DME DM72JXH MA Metabolism DM72JXH RN Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. DM72JXH RU https://www.ncbi.nlm.nih.gov/pubmed/?term=19515014 DM8QTJI DI DM8QTJI DM8QTJI DN Loteprednol etabonate DM8QTJI MI DE4LYSA DM8QTJI MN Cytochrome P450 3A4 (CYP3A4) DM8QTJI MT DME DM8QTJI MA Metabolism DM8QTJI RN EMC: Lotemax 0.5% w/v Eye Drops, Suspension. DM8QTJI RU https://www.medicines.org.uk/emc/product/6212 DM8QTJI DI DM8QTJI DM8QTJI DN Loteprednol etabonate DM8QTJI MI DESDN74 DM8QTJI MN Serum paraoxonase/arylesterase 1 (PON1) DM8QTJI MT DME DM8QTJI MA Metabolism DM8QTJI RN Identification of esterase involved in the metabolism of two corticosteroid soft drugs. Biochem Pharmacol. 2017 Mar 1;127:82-89. DM8QTJI RU https://www.ncbi.nlm.nih.gov/pubmed/?term=28017774 DM8QTJI DI DM8QTJI DM8QTJI DN Loteprednol etabonate DM8QTJI MI TTP3UTW DM8QTJI MN Steroid hormone receptor ERR (ESRR) DM8QTJI MT DTT DM8QTJI MA Modulator DM8QTJI RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. DM8QTJI RU https://www.fda.gov/ DM9OZWQ DI DM9OZWQ DM9OZWQ DN Lovastatin DM9OZWQ MI DES5XRU DM9OZWQ MN Cytochrome P450 2C8 (CYP2C8) DM9OZWQ MT DME DM9OZWQ MA Metabolism DM9OZWQ RN Pharmacogenomics of statins: understanding susceptibility to adverse effects. Pharmgenomics Pers Med. 2016 Oct 3;9:97-106. DM9OZWQ RU https://www.ncbi.nlm.nih.gov/pubmed/?term=27757045 DM9OZWQ DI DM9OZWQ DM9OZWQ DN Lovastatin DM9OZWQ MI DE4LYSA DM9OZWQ MN Cytochrome P450 3A4 (CYP3A4) DM9OZWQ MT DME DM9OZWQ MA Metabolism DM9OZWQ RN Metabolic interactions with statins. Tidsskr Nor Laegeforen. 2001 Jan 20;121(2):189-93. DM9OZWQ RU https://www.ncbi.nlm.nih.gov/pubmed/?term=11475198 DM9OZWQ DI DM9OZWQ DM9OZWQ DN Lovastatin DM9OZWQ MI TTPADOQ DM9OZWQ MN HMG-CoA reductase (HMGCR) DM9OZWQ MT DTT DM9OZWQ MA Inhibitor DM9OZWQ RN Microarray and biochemical analysis of lovastatin-induced apoptosis of squamous cell carcinomas. Neoplasia. 2002 Jul-Aug;4(4):337-46. DM9OZWQ RU https://pubmed.ncbi.nlm.nih.gov/12082550 DM9OZWQ DI DM9OZWQ DM9OZWQ DN Lovastatin DM9OZWQ MI DEGTFWK DM9OZWQ MN Mephenytoin 4-hydroxylase (CYP2C19) DM9OZWQ MT DME DM9OZWQ MA Metabolism DM9OZWQ RN Pharmacogenomics of statins: understanding susceptibility to adverse effects. Pharmgenomics Pers Med. 2016 Oct 3;9:97-106. DM9OZWQ RU https://www.ncbi.nlm.nih.gov/pubmed/?term=27757045 DM9OZWQ DI DM9OZWQ DM9OZWQ DN Lovastatin DM9OZWQ MI DT3D8F0 DM9OZWQ MN Organic anion transporting polypeptide 1B1 (SLCO1B1) DM9OZWQ MT DTP DM9OZWQ MA Substrate DM9OZWQ RN A novel human hepatic organic anion transporting polypeptide (OATP2). Identification of a liver-specific human organic anion transporting polypeptide and identification of rat and human hydroxymethylglutaryl-CoA reductase inhibitor transporters. J Biol Chem. 1999 Dec 24;274(52):37161-8. DM9OZWQ RU http://www.ncbi.nlm.nih.gov/pubmed/10601278 DM9OZWQ DI DM9OZWQ DM9OZWQ DN Lovastatin DM9OZWQ MI DTUGYRD DM9OZWQ MN P-glycoprotein 1 (ABCB1) DM9OZWQ MT DTP DM9OZWQ MA Substrate DM9OZWQ RN Mammalian drug efflux transporters of the ATP binding cassette (ABC) family in multidrug resistance: A review of the past decade. Cancer Lett. 2016 Jan 1;370(1):153-64. DM9OZWQ RU http://www.ncbi.nlm.nih.gov/pubmed/26499806 DM9OZWQ DI DM9OZWQ DM9OZWQ DN Lovastatin DM9OZWQ MI DETXQZ1 DM9OZWQ MN Serum paraoxonase/lactonase 3 (PON3) DM9OZWQ MT DME DM9OZWQ MA Metabolism DM9OZWQ RN Paraoxonases-1, -2 and -3: what are their functions? Chem Biol Interact. 2016 Nov 25;259(Pt B):51-62. DM9OZWQ RU https://www.ncbi.nlm.nih.gov/pubmed/?term=27238723 DM9OZWQ DI DM9OZWQ DM9OZWQ DN Lovastatin DM9OZWQ MI DEYGVN4 DM9OZWQ MN UDP-glucuronosyltransferase 1A1 (UGT1A1) DM9OZWQ MT DME DM9OZWQ MA Metabolism DM9OZWQ RN Pharmacogenomics of statins: understanding susceptibility to adverse effects. Pharmgenomics Pers Med. 2016 Oct 3;9:97-106. DM9OZWQ RU https://www.ncbi.nlm.nih.gov/pubmed/?term=27757045 DM9OZWQ DI DM9OZWQ DM9OZWQ DN Lovastatin DM9OZWQ MI DEF2WXN DM9OZWQ MN UDP-glucuronosyltransferase 1A3 (UGT1A3) DM9OZWQ MT DME DM9OZWQ MA Metabolism DM9OZWQ RN Pharmacogenomics of statins: understanding susceptibility to adverse effects. Pharmgenomics Pers Med. 2016 Oct 3;9:97-106. DM9OZWQ RU https://www.ncbi.nlm.nih.gov/pubmed/?term=27757045 DM9OZWQ DI DM9OZWQ DM9OZWQ DN Lovastatin DM9OZWQ MI DEB3CV1 DM9OZWQ MN UDP-glucuronosyltransferase 2B7 (UGT2B7) DM9OZWQ MT DME DM9OZWQ MA Metabolism DM9OZWQ RN Pharmacogenomics of statins: understanding susceptibility to adverse effects. Pharmgenomics Pers Med. 2016 Oct 3;9:97-106. DM9OZWQ RU https://www.ncbi.nlm.nih.gov/pubmed/?term=27757045 DMGCQ4E DI DMGCQ4E DMGCQ4E DN Lovastatin acid DMGCQ4E MI DTUGYRD DMGCQ4E MN P-glycoprotein 1 (ABCB1) DMGCQ4E MT DTP DMGCQ4E MA Substrate DMGCQ4E RN Human intestinal transporter database: QSAR modeling and virtual profiling of drug uptake, efflux and interactions. Pharm Res. 2013 Apr;30(4):996-1007. DMGCQ4E RU https://doi.org/10.1007/s11095-012-0935-x DM8AI9U DI DM8AI9U DM8AI9U DN Loxapine DM8AI9U MI DEJGDUW DM8AI9U MN Cytochrome P450 1A2 (CYP1A2) DM8AI9U MT DME DM8AI9U MA Metabolism DM8AI9U RN In vitro identification of the human cytochrome p450 enzymes involved in the oxidative metabolism of loxapine. Biopharm Drug Dispos. 2011 Oct;32(7):398-407. DM8AI9U RU https://www.ncbi.nlm.nih.gov/pubmed/?term=21826677 DM8AI9U DI DM8AI9U DM8AI9U DN Loxapine DM8AI9U MI DECB0K3 DM8AI9U MN Cytochrome P450 2D6 (CYP2D6) DM8AI9U MT DME DM8AI9U MA Metabolism DM8AI9U RN In vitro identification of the human cytochrome p450 enzymes involved in the oxidative metabolism of loxapine. Biopharm Drug Dispos. 2011 Oct;32(7):398-407. DM8AI9U RU https://www.ncbi.nlm.nih.gov/pubmed/?term=21826677 DM8AI9U DI DM8AI9U DM8AI9U DN Loxapine DM8AI9U MI DE4LYSA DM8AI9U MN Cytochrome P450 3A4 (CYP3A4) DM8AI9U MT DME DM8AI9U MA Metabolism DM8AI9U RN In vitro identification of the human cytochrome p450 enzymes involved in the oxidative metabolism of loxapine. Biopharm Drug Dispos. 2011 Oct;32(7):398-407. DM8AI9U RU https://www.ncbi.nlm.nih.gov/pubmed/?term=21826677 DM8AI9U DI DM8AI9U DM8AI9U DN Loxapine DM8AI9U MI TTEX248 DM8AI9U MN Dopamine D2 receptor (D2R) DM8AI9U MT DTT DM8AI9U MA Antagonist DM8AI9U RN Remoxipride in Parkinson's disease: differential response in patients with dyskinesias fluctuations versus psychosis. Clin Neuropharmacol. 1995 Feb;18(1):39-45. DM8AI9U RU https://pubmed.ncbi.nlm.nih.gov/8665533 DMQMGXV DI DMQMGXV DMQMGXV DN Loxoprofen gel DMQMGXV MI TTK0943 DMQMGXV MN Prostaglandin G/H synthase (COX) DMQMGXV MT DTT DMQMGXV MA Inhibitor DMQMGXV RN Comparative study of the clinical efficacy of the selective cyclooxygenase-2 inhibitor celecoxib compared with loxoprofen in patients with frozen shoulder. Mod Rheumatol. 2014 Jan;24(1):144-9. DMQMGXV RU https://pubmed.ncbi.nlm.nih.gov/24261771 DMQXI9F DI DMQXI9F DMQXI9F DN L-Phenylalanine DMQXI9F MI DTJF3DX DMQXI9F MN L-type amino acid transporter 2 (SLC7A8) DMQXI9F MT DTP DMQXI9F MA Substrate DMQXI9F RN Quantifying the relative contributions of different solute carriers to aggregate substrate transport. Sci Rep. 2017 Jan 16;7:40628. DMQXI9F RU http://www.ncbi.nlm.nih.gov/pubmed/28091567 DMQXI9F DI DMQXI9F DMQXI9F DN L-Phenylalanine DMQXI9F MI DTBMSWG DMQXI9F MN L-type amino acid transporter 3 (SLC43A1) DMQXI9F MT DTP DMQXI9F MA Substrate DMQXI9F RN Identification of a novel system L amino acid transporter structurally distinct from heterodimeric amino acid transporters. J Biol Chem. 2003 Oct 31;278(44):43838-45. DMQXI9F RU http://www.ncbi.nlm.nih.gov/pubmed/12930836 DMQXI9F DI DMQXI9F DMQXI9F DN L-Phenylalanine DMQXI9F MI DTK02I1 DMQXI9F MN L-type amino acid transporter 4 (SLC43A2) DMQXI9F MT DTP DMQXI9F MA Substrate DMQXI9F RN Anticipation of food intake induces phosphorylation switch to regulate basolateral amino acid transporter LAT4 (SLC43A2) function. J Physiol. 2019 Jan;597(2):521-542. DMQXI9F RU http://www.ncbi.nlm.nih.gov/pubmed/30379325 DMQXI9F DI DMQXI9F DMQXI9F DN L-Phenylalanine DMQXI9F MI DE0WGR8 DMQXI9F MN Phenylalanine--tRNA ligase mitochondrial (FARS2) DMQXI9F MT DME DMQXI9F MA Metabolism DMQXI9F RN Expression and characterization of a human mitochondrial phenylalanyl-tRNA synthetase. J Mol Biol. 1999 May 14;288(4):567-77. DMQXI9F RU https://www.ncbi.nlm.nih.gov/pubmed/?term=10329163 DMQXI9F DI DMQXI9F DMQXI9F DN L-Phenylalanine DMQXI9F MI TTUHP71 DMQXI9F MN Tyrosine 3-monooxygenase (TH) DMQXI9F MT DTT DMQXI9F MA Binder DMQXI9F RN Selectivity and affinity determinants for ligand binding to the aromatic amino acid hydroxylases. Curr Med Chem. 2007;14(4):455-67. DMQXI9F RU https://pubmed.ncbi.nlm.nih.gov/17305546 DMKSTWR DI DMKSTWR DMKSTWR DN L-Proline DMKSTWR MI DTJF3DX DMKSTWR MN L-type amino acid transporter 2 (SLC7A8) DMKSTWR MT DTP DMKSTWR MA Substrate DMKSTWR RN The Transporter Classification Database (TCDB): recent advances. Nucleic Acids Res. 2016 Jan 4;44(D1):D372-9. (ID: 2.A.3.8.20) DMKSTWR RU http://www.tcdb.org/search/result.php?tc=2.A.3.8.20 DMKSTWR DI DMKSTWR DMKSTWR DN L-Proline DMKSTWR MI DTBPTJF DMKSTWR MN Na(+)/Cl(-) betaine/GABA transporter (SLC6A12) DMKSTWR MT DTP DMKSTWR MA Substrate DMKSTWR RN Interpreting metabolomic profiles using unbiased pathway models. PLoS Comput Biol. 2010 Feb 26;6(2):e1000692. DMKSTWR RU http://www.ncbi.nlm.nih.gov/pubmed/20195502 DMKSTWR DI DMKSTWR DMKSTWR DN L-Proline DMKSTWR MI DT48WEM DMKSTWR MN Proton-coupled amino acid transporter 1 (SLC36A1) DMKSTWR MT DTP DMKSTWR MA Substrate DMKSTWR RN PAT1 (SLC36A1) shows nuclear localization and affects growth of smooth muscle cells from rats. Am J Physiol Endocrinol Metab. 2014 Jan 1;306(1):E65-74. DMKSTWR RU http://www.ncbi.nlm.nih.gov/pubmed/24222668 DMKSTWR DI DMKSTWR DMKSTWR DN L-Proline DMKSTWR MI DTBS49U DMKSTWR MN Proton-coupled amino acid transporter 4 (SLC36A4) DMKSTWR MT DTP DMKSTWR MA Substrate DMKSTWR RN SLC36A4 (hPAT4) is a high affinity amino acid transporter when expressed in Xenopus laevis oocytes. J Biol Chem. 2011 Jan 28;286(4):2455-60. DMKSTWR RU http://www.ncbi.nlm.nih.gov/pubmed/21097500 DMKSTWR DI DMKSTWR DMKSTWR DN L-Proline DMKSTWR MI TTL2ADK DMKSTWR MN Rotamase A (PPIA) DMKSTWR MT DTT DMKSTWR MA Binder DMKSTWR RN Mechanistic insight into the role of transition-state stabilization in cyclophilin A. J Am Chem Soc. 2009 Jan 14;131(1):147-52. DMKSTWR RU https://pubmed.ncbi.nlm.nih.gov/19128175 DMKSTWR DI DMKSTWR DMKSTWR DN L-Proline DMKSTWR MI TT6ZFQ4 DMKSTWR MN Rotamase B (PPIB) DMKSTWR MT DTT DMKSTWR MA Binder DMKSTWR RN Escherichia coli cyclophilin B binds a highly distorted form of trans-prolyl peptide isomer. Eur J Biochem. 2004 Sep;271(18):3794-803. DMKSTWR RU https://pubmed.ncbi.nlm.nih.gov/15355356 DMKSTWR DI DMKSTWR DMKSTWR DN L-Proline DMKSTWR MI DTH1GEL DMKSTWR MN Sodium-dependent proline transporter (SLC6A7) DMKSTWR MT DTP DMKSTWR MA Substrate DMKSTWR RN A new association between polymorphisms of the SLC6A7 gene in the chromosome 5q31-32 region and asthma. J Hum Genet. 2010 Jun;55(6):358-65. DMKSTWR RU http://www.ncbi.nlm.nih.gov/pubmed/20431603 DMIBH7M DI DMIBH7M DMIBH7M DN L-tryptophan DMIBH7M MI DETK9CN DMIBH7M MN DOPA decarboxylase (DDC) DMIBH7M MT DME DMIBH7M MA Metabolism DMIBH7M RN Origin and metabolism of serotonin. J Cardiovasc Pharmacol. 1990;16 Suppl 3:S1-7. DMIBH7M RU https://www.ncbi.nlm.nih.gov/pubmed/?term=1369709 DMIBH7M DI DMIBH7M DMIBH7M DN L-tryptophan DMIBH7M MI TTZJYKH DMIBH7M MN Indoleamine 2,3-dioxygenase 1 (IDO1) DMIBH7M MT DTT DMIBH7M MA Binder DMIBH7M RN Interactions between nitric oxide and indoleamine 2,3-dioxygenase. Biochemistry. 2006 Jul 18;45(28):8527-38. DMIBH7M RU https://pubmed.ncbi.nlm.nih.gov/16834326 DMIBH7M DI DMIBH7M DMIBH7M DN L-tryptophan DMIBH7M MI DE43MW5 DMIBH7M MN Indoleamine 2,3-dioxygenase 1 (IDO1) DMIBH7M MT DME DMIBH7M MA Metabolism DMIBH7M RN Kynurenine pathway metabolites and enzymes involved in redox reactions. Neuropharmacology. 2017 Jan;112(Pt B):331-345. DMIBH7M RU https://www.ncbi.nlm.nih.gov/pubmed/?term=26970015 DMIBH7M DI DMIBH7M DMIBH7M DN L-tryptophan DMIBH7M MI DE8BVKA DMIBH7M MN Indoleamine 2,3-dioxygenase 2 (IDO2) DMIBH7M MT DME DMIBH7M MA Metabolism DMIBH7M RN Kynurenine pathway metabolites and enzymes involved in redox reactions. Neuropharmacology. 2017 Jan;112(Pt B):331-345. DMIBH7M RU https://www.ncbi.nlm.nih.gov/pubmed/?term=26970015 DMIBH7M DI DMIBH7M DMIBH7M DN L-tryptophan DMIBH7M MI DTJF3DX DMIBH7M MN L-type amino acid transporter 2 (SLC7A8) DMIBH7M MT DTP DMIBH7M MA Substrate DMIBH7M RN The Transporter Classification Database (TCDB): recent advances. Nucleic Acids Res. 2016 Jan 4;44(D1):D372-9. (ID: 2.A.3.8.20) DMIBH7M RU http://www.tcdb.org/search/result.php?tc=2.A.3.8.20 DMIBH7M DI DMIBH7M DMIBH7M DN L-tryptophan DMIBH7M MI DTPAQJO DMIBH7M MN Monocarboxylate transporter 10 (SLC16A10) DMIBH7M MT DTP DMIBH7M MA Substrate DMIBH7M RN Phosphatidylserine synthesis required for the maximal tryptophan transport activity in Saccharomyces cerevisiae. Biosci Biotechnol Biochem. 2000 Jan;64(1):167-72. DMIBH7M RU http://www.ncbi.nlm.nih.gov/pubmed/10705462 DMIBH7M DI DMIBH7M DMIBH7M DN L-tryptophan DMIBH7M MI DTVP67E DMIBH7M MN Organic anion transporter 3 (SLC22A8) DMIBH7M MT DTP DMIBH7M MA Substrate DMIBH7M RN Murine renal organic anion transporters mOAT1 and mOAT3 facilitate the transport of neuroactive tryptophan metabolites. Am J Physiol Cell Physiol. 2005 Nov;289(5):C1075-84. DMIBH7M RU http://www.ncbi.nlm.nih.gov/pubmed/15944205 DMIBH7M DI DMIBH7M DMIBH7M DN L-tryptophan DMIBH7M MI DTUGYRD DMIBH7M MN P-glycoprotein 1 (ABCB1) DMIBH7M MT DTP DMIBH7M MA Substrate DMIBH7M RN Pharmacogenetics of antidepressants. Front Pharmacol. 2011 Feb 16;2:6. DMIBH7M RU http://www.ncbi.nlm.nih.gov/pubmed/21687501 DMIBH7M DI DMIBH7M DMIBH7M DN L-tryptophan DMIBH7M MI DTBS49U DMIBH7M MN Proton-coupled amino acid transporter 4 (SLC36A4) DMIBH7M MT DTP DMIBH7M MA Substrate DMIBH7M RN SLC36A4 (hPAT4) is a high affinity amino acid transporter when expressed in Xenopus laevis oocytes. J Biol Chem. 2011 Jan 28;286(4):2455-60. DMIBH7M RU http://www.ncbi.nlm.nih.gov/pubmed/21097500 DMIBH7M DI DMIBH7M DMIBH7M DN L-tryptophan DMIBH7M MI DEP5BDK DMIBH7M MN Tryptophan 5-hydroxylase 1 (TPH1) DMIBH7M MT DME DMIBH7M MA Metabolism DMIBH7M RN Developmental role of tryptophan hydroxylase in the nervous system. Mol Neurobiol. 2007 Feb;35(1):45-54. DMIBH7M RU https://www.ncbi.nlm.nih.gov/pubmed/?term=17519505 DMIBH7M DI DMIBH7M DMIBH7M DN L-tryptophan DMIBH7M MI DER6XYF DMIBH7M MN Tryptophan 5-hydroxylase 2 (TPH2) DMIBH7M MT DME DMIBH7M MA Metabolism DMIBH7M RN Strain differences in basal and post-citalopram extracellular 5-HT in the mouse medial prefrontal cortex and dorsal hippocampus: relation with tryptophan hydroxylase-2 activity. J Neurochem. 2007 Nov;103(3):1111-20. DMIBH7M RU https://www.ncbi.nlm.nih.gov/pubmed/?term=17666043 DMIBH7M DI DMIBH7M DMIBH7M DN L-tryptophan DMIBH7M MI DEGH1QU DMIBH7M MN Tryptophan oxygenase (TRPO) DMIBH7M MT DME DMIBH7M MA Metabolism DMIBH7M RN Reaction pathway of tryptophanase-catalyzed L-tryptophan synthesis from D-serine. J Chromatogr B Analyt Technol Biomed Life Sci. 2011 Nov 1;879(29):3289-95. DMIBH7M RU https://www.ncbi.nlm.nih.gov/pubmed/?term=21601540 DMIBH7M DI DMIBH7M DMIBH7M DN L-tryptophan DMIBH7M MI DEPVE0M DMIBH7M MN Tryptophanyl-tRNA synthetase cytoplasmic (WARS1) DMIBH7M MT DME DMIBH7M MA Metabolism DMIBH7M RN IFN-gamma-induced IDO and WRS expression in microglia is differentially regulated by IL-4. Glia. 2007 Oct;55(13):1385-96. DMIBH7M RU https://www.ncbi.nlm.nih.gov/pubmed/?term=17661345 DMIBH7M DI DMIBH7M DMIBH7M DN L-tryptophan DMIBH7M MI DEPTKBQ DMIBH7M MN Tryptophanyl-tRNA synthetase mitochondrial (WARS2) DMIBH7M MT DME DMIBH7M MA Metabolism DMIBH7M RN Crystal structure of tryptophanyl-tRNA synthetase complexed with adenosine-5' tetraphosphate: evidence for distributed use of catalytic binding energy in amino acid activation by class I aminoacyl-tRNA synthetases. J Mol Biol. 2007 May 25;369(1):108-28. DMIBH7M RU https://www.ncbi.nlm.nih.gov/pubmed/?term=17428498 DM9O8DT DI DM9O8DT DM9O8DT DN L-tyrosine DM9O8DT MI DTJF3DX DM9O8DT MN L-type amino acid transporter 2 (SLC7A8) DM9O8DT MT DTP DM9O8DT MA Substrate DM9O8DT RN The Transporter Classification Database (TCDB): recent advances. Nucleic Acids Res. 2016 Jan 4;44(D1):D372-9. (ID: 2.A.3.8.20) DM9O8DT RU http://www.tcdb.org/search/result.php?tc=2.A.3.8.20 DM9O8DT DI DM9O8DT DM9O8DT DN L-tyrosine DM9O8DT MI TTUHP71 DM9O8DT MN Tyrosine 3-monooxygenase (TH) DM9O8DT MT DTT DM9O8DT MA Binder DM9O8DT RN Effect of metals and phenylalanine on the activity of human tryptophan hydroxylase-2: comparison with that on tyrosine hydroxylase activity. Neurosci Lett. 2006 Jul 3;401(3):261-5. DM9O8DT RU https://pubmed.ncbi.nlm.nih.gov/16581181 DM9O8DT DI DM9O8DT DM9O8DT DN L-tyrosine DM9O8DT MI DEX2ZLF DM9O8DT MN Tyrosine decarboxylase (tdc) DM9O8DT MT DME DM9O8DT MA Metabolism DM9O8DT RN Tyrosine decarboxylase from Lactobacillus brevis: soluble expression and characterization. Protein Expr Purif. 2014 Feb;94:33-9. DM9O8DT RU https://pubmed.ncbi.nlm.nih.gov/24211777 DMMJVXZ DI DMMJVXZ DMMJVXZ DN LU302146 DMMJVXZ MI TTKRD0G DMMJVXZ MN Endothelin A receptor (EDNRA) DMMJVXZ MT DTT DMMJVXZ MA Antagonist DMMJVXZ RN Influence of endothelin receptor antagonists on myocardial protein kinase C isoforms in uraemic cardiomyopathy. Clin Sci (Lond). 2002 Aug;103 Suppl 48:276S-279S. DMMJVXZ RU https://pubmed.ncbi.nlm.nih.gov/12193103 DMJTEMW DI DMJTEMW DMJTEMW DN Lubiprostone DMJTEMW MI TT30NW6 DMJTEMW MN Chloride channel protein 2 (CLC-2) DMJTEMW MT DTT DMJTEMW MA Activator DMJTEMW RN Lubiprostone stimulates secretion from tracheal submucosal glands of sheep, pigs, and humans. Am J Physiol Lung Cell Mol Physiol. 2009 May;296(5):L811-24. DMJTEMW RU https://pubmed.ncbi.nlm.nih.gov/19233902 DMZLBUO DI DMZLBUO DMZLBUO DN Lucanthone DMZLBUO MI TT0IHXV DMZLBUO MN DNA topoisomerase II (TOP2) DMZLBUO MT DTT DMZLBUO MA Inhibitor DMZLBUO RN Clonogenicity of human leukemic cells protected from cell-lethal agents by heat shock protein 70. Cell Stress Chaperones. 2005 Spring;10(1):37-45. DMZLBUO RU https://pubmed.ncbi.nlm.nih.gov/15832946 DMT73J8 DI DMT73J8 DMT73J8 DN Luliconazole DMT73J8 MI TTTSOUD DMT73J8 MN Candida Cytochrome P450 51 (Candi ERG11) DMT73J8 MT DTT DMT73J8 MA Inhibitor DMT73J8 RN Radium 223 dichloride for prostate cancer treatment. Drug Des Devel Ther. 2017 Sep 6;11:2643-2651. DMT73J8 RU https://pubmed.ncbi.nlm.nih.gov/28919714 DMUPOGR DI DMUPOGR DMUPOGR DN Lumacaftor + Ivacaftor DMUPOGR MI TTRLZHP DMUPOGR MN cAMP-dependent chloride channel (CFTR) DMUPOGR MT DTT DMUPOGR MA Enhancer DMUPOGR RN Antibodies and venom peptides: new modalities for ion channels. Nat Rev Drug Discov. 2019 May;18(5):339-357. DMUPOGR RU https://pubmed.ncbi.nlm.nih.gov/30728472 DMUPOGR DI DMUPOGR DMUPOGR DN Lumacaftor + Ivacaftor DMUPOGR MI TTFPKRB DMUPOGR MN cAMP-dependent chloride channel F508 deletion (CFTR del F508) DMUPOGR MT DTT DMUPOGR MA Enhancer DMUPOGR RN Antibodies and venom peptides: new modalities for ion channels. Nat Rev Drug Discov. 2019 May;18(5):339-357. DMUPOGR RU https://pubmed.ncbi.nlm.nih.gov/30728472 DMEBQAO DI DMEBQAO DMEBQAO DN Lumasiran DMEBQAO MI TTS58YO DMEBQAO MN HAO1 messenger RNA (HAO1 mRNA) DMEBQAO MT DTT DMEBQAO MA Inhibitor DMEBQAO RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health Human Services. 2020 DMEBQAO RU https://www.accessdata.fda.gov/drugsatfda_docs/label/2020/214103lbl.pdf DMQ8HOJ DI DMQ8HOJ DMQ8HOJ DN lumateperone tosylate DMQ8HOJ MI TTJQOD7 DMQ8HOJ MN 5-HT 2A receptor (HTR2A) DMQ8HOJ MT DTT DMQ8HOJ MA Antagonist DMQ8HOJ RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health Human Services. 2019 DMQ8HOJ RU https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/209500s000lbl.pdf DMQ8HOJ DI DMQ8HOJ DMQ8HOJ DN lumateperone tosylate DMQ8HOJ MI TTEX248 DMQ8HOJ MN Dopamine D2 receptor (D2R) DMQ8HOJ MT DTT DMQ8HOJ MA Antagonist DMQ8HOJ RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health Human Services. 2019 DMQ8HOJ RU https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/209500s000lbl.pdf DM29GAD DI DM29GAD DM29GAD DN Lumefantrine DM29GAD MI DE4LYSA DM29GAD MN Cytochrome P450 3A4 (CYP3A4) DM29GAD MT DME DM29GAD MA Metabolism DM29GAD RN Development of a paediatric physiologically based pharmacokinetic model to assess the impact of drug-drug interactions in tuberculosis co-infected malaria subjects: A case study with artemether-lumefantrine and the CYP3A4-inducer rifampicin. Eur J Pharm Sci. 2017 Aug 30;106:20-33. DM29GAD RU https://www.ncbi.nlm.nih.gov/pubmed/?term=28546104 DM29GAD DI DM29GAD DM29GAD DN Lumefantrine DM29GAD MI TTWK8D0 DM29GAD MN Sodium pump subunit alpha-1 (ATP1A1) DM29GAD MT DTT DM29GAD MA Binder DM29GAD RN The fight against drug-resistant malaria: novel plasmodial targets and antimalarial drugs. Curr Med Chem. 2008;15(2):161-71. DM29GAD RU https://pubmed.ncbi.nlm.nih.gov/18220771 DM1S4AG DI DM1S4AG DM1S4AG DN Lumiracoxib DM1S4AG MI DEJGDUW DM1S4AG MN Cytochrome P450 1A2 (CYP1A2) DM1S4AG MT DME DM1S4AG MA Metabolism DM1S4AG RN Clinical pharmacology of lumiracoxib: a selective cyclo-oxygenase-2 inhibitor. Clin Pharmacokinet. 2005;44(12):1247-66. DM1S4AG RU https://www.ncbi.nlm.nih.gov/pubmed/?term=16372823 DM1S4AG DI DM1S4AG DM1S4AG DN Lumiracoxib DM1S4AG MI DE5IED8 DM1S4AG MN Cytochrome P450 2C9 (CYP2C9) DM1S4AG MT DME DM1S4AG MA Metabolism DM1S4AG RN Clinical pharmacology of lumiracoxib: a selective cyclo-oxygenase-2 inhibitor. Clin Pharmacokinet. 2005;44(12):1247-66. DM1S4AG RU https://www.ncbi.nlm.nih.gov/pubmed/?term=16372823 DM1S4AG DI DM1S4AG DM1S4AG DN Lumiracoxib DM1S4AG MI DEGTFWK DM1S4AG MN Mephenytoin 4-hydroxylase (CYP2C19) DM1S4AG MT DME DM1S4AG MA Metabolism DM1S4AG RN Clinical pharmacology of lumiracoxib: a selective cyclo-oxygenase-2 inhibitor. Clin Pharmacokinet. 2005;44(12):1247-66. DM1S4AG RU https://www.ncbi.nlm.nih.gov/pubmed/?term=16372823 DM1S4AG DI DM1S4AG DM1S4AG DN Lumiracoxib DM1S4AG MI TTVKILB DM1S4AG MN Prostaglandin G/H synthase 2 (COX-2) DM1S4AG MT DTT DM1S4AG MA Inhibitor DM1S4AG RN Dissociation of airway inflammation and hyperresponsiveness by cyclooxygenase inhibition in allergen challenged mice. Eur Respir J. 2009 Jul;34(1):200-8. DM1S4AG RU https://pubmed.ncbi.nlm.nih.gov/19251789 DM1S4AG DI DM1S4AG DM1S4AG DN Lumiracoxib DM1S4AG MI DE85D2P DM1S4AG MN UDP-glucuronosyltransferase 1A9 (UGT1A9) DM1S4AG MT DME DM1S4AG MA Metabolism DM1S4AG RN Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. DM1S4AG RU https://www.ncbi.nlm.nih.gov/pubmed/?term=19515014 DMCVPXO DI DMCVPXO DMCVPXO DN Lurasidone hydrochloride DMCVPXO MI TTJQOD7 DMCVPXO MN 5-HT 2A receptor (HTR2A) DMCVPXO MT DTT DMCVPXO MA Modulator DMCVPXO RN Mullard A: 2010 FDA drug approvals. Nat Rev Drug Discov. 2011 Feb;10(2):82-5. DMCVPXO RU https://pubmed.ncbi.nlm.nih.gov/21283092 DMCVPXO DI DMCVPXO DMCVPXO DN Lurasidone hydrochloride DMCVPXO MI DE4LYSA DMCVPXO MN Cytochrome P450 3A4 (CYP3A4) DMCVPXO MT DME DMCVPXO MA Metabolism DMCVPXO RN Pharmacokinetics and pharmacodynamics of lurasidone hydrochloride, a second-generation antipsychotic: a systematic review of the published literature. Clin Pharmacokinet. 2017 May;56(5):493-503. DMCVPXO RU https://www.ncbi.nlm.nih.gov/pubmed/?term=27722855 DMCVPXO DI DMCVPXO DMCVPXO DN Lurasidone hydrochloride DMCVPXO MI TTEX248 DMCVPXO MN Dopamine D2 receptor (D2R) DMCVPXO MT DTT DMCVPXO MA Modulator DMCVPXO RN Mullard A: 2010 FDA drug approvals. Nat Rev Drug Discov. 2011 Feb;10(2):82-5. DMCVPXO RU https://pubmed.ncbi.nlm.nih.gov/21283092 DMEFRTZ DI DMEFRTZ DMEFRTZ DN Lurbinectedin DMEFRTZ MI TTUTN1I DMEFRTZ MN Human Deoxyribonucleic acid (hDNA) DMEFRTZ MT DTT DMEFRTZ MA Inhibitor DMEFRTZ RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health Human Services. 2020 DMEFRTZ RU https://www.accessdata.fda.gov/drugsatfda_docs/label/2020/213702s000lbl.pdf DMEFRTZ DI DMEFRTZ DMEFRTZ DN Lurbinectedin DMEFRTZ MI TTOVXHF DMEFRTZ MN Human Deoxyribonucleic acid minor groove (hDNA min) DMEFRTZ MT DTT DMEFRTZ MA Inhibitor DMEFRTZ RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health Human Services. 2020 DMEFRTZ RU https://www.accessdata.fda.gov/drugsatfda_docs/label/2020/213702s000lbl.pdf DMH6IKO DI DMH6IKO DMH6IKO DN Lusutrombopag DMH6IKO MI TTIHYA4 DMH6IKO MN Thrombopoietin receptor (MPL) DMH6IKO MT DTT DMH6IKO MA Agonist DMH6IKO RN 2018 FDA drug approvals.Nat Rev Drug Discov. 2019 Feb;18(2):85-89. DMH6IKO RU https://pubmed.ncbi.nlm.nih.gov/30710142 DMN1XVC DI DMN1XVC DMN1XVC DN Lutetium Lu 177 dotatate DMN1XVC MI TTIND6G DMN1XVC MN Somatostatin receptor type 1 (SSTR1) DMN1XVC MT DTT DMN1XVC MA Antagonist DMN1XVC RN 2018 FDA drug approvals.Nat Rev Drug Discov. 2019 Feb;18(2):85-89. DMN1XVC RU https://pubmed.ncbi.nlm.nih.gov/30710142 DM7K5GD DI DM7K5GD DM7K5GD DN Lutropin alfa DM7K5GD MI TT2O4W9 DM7K5GD MN Luteinizing hormone receptor (LHCGR) DM7K5GD MT DTT DM7K5GD MA Binder DM7K5GD RN Lutropin alfa. Drugs. 2008;68(11):1529-40. DM7K5GD RU https://pubmed.ncbi.nlm.nih.gov/18627209 DMJKROX DI DMJKROX DMJKROX DN Luvox DMJKROX MI DEJGDUW DMJKROX MN Cytochrome P450 1A2 (CYP1A2) DMJKROX MT DME DMJKROX MA Metabolism DMJKROX RN Effect of fluvoxamine on the pharmacokinetics of roflumilast and roflumilast N-oxide. Clin Pharmacokinet. 2007;46(7):613-22. DMJKROX RU https://www.ncbi.nlm.nih.gov/pubmed/?term=17596106 DMJKROX DI DMJKROX DMJKROX DN Luvox DMJKROX MI DECB0K3 DMJKROX MN Cytochrome P450 2D6 (CYP2D6) DMJKROX MT DME DMJKROX MA Metabolism DMJKROX RN Is therapeutic drug monitoring a case for optimizing clinical outcome and avoiding interactions of the selective serotonin reuptake inhibitors? Ther Drug Monit. 2000 Apr;22(2):143-54. DMJKROX RU https://www.ncbi.nlm.nih.gov/pubmed/?term=10774624 DMJKROX DI DMJKROX DMJKROX DN Luvox DMJKROX MI DEVDYN7 DMJKROX MN Cytochrome P450 2E1 (CYP2E1) DMJKROX MT DME DMJKROX MA Metabolism DMJKROX RN Antidepressant drugs in the elderly--role of the cytochrome P450 2D6. World J Biol Psychiatry. 2003 Apr;4(2):74-80. DMJKROX RU https://www.ncbi.nlm.nih.gov/pubmed/?term=12692778 DMJKROX DI DMJKROX DMJKROX DN Luvox DMJKROX MI TT3ROYC DMJKROX MN Serotonin transporter (SERT) DMJKROX MT DTT DMJKROX MA Modulator DMJKROX RN Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41. DMJKROX RU https://www.ncbi.nlm.nih.gov/pubmed/15950434 DM93VBZ DI DM93VBZ DM93VBZ DN LY2835219 DM93VBZ MI TT0PG8F DM93VBZ MN Cyclin-dependent kinase 4 (CDK4) DM93VBZ MT DTT DM93VBZ MA Modulator DM93VBZ RN Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41. DM93VBZ RU https://www.ncbi.nlm.nih.gov/pubmed/15950434 DM93VBZ DI DM93VBZ DM93VBZ DN LY2835219 DM93VBZ MI TTO0FDJ DM93VBZ MN Cyclin-dependent kinase 6 (CDK6) DM93VBZ MT DTT DM93VBZ MA Modulator DM93VBZ RN Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41. DM93VBZ RU https://www.ncbi.nlm.nih.gov/pubmed/15950434 DM93VBZ DI DM93VBZ DM93VBZ DN LY2835219 DM93VBZ MI DE4LYSA DM93VBZ MN Cytochrome P450 3A4 (CYP3A4) DM93VBZ MT DME DM93VBZ MA Metabolism DM93VBZ RN LiverTox: Clinical and Research Information on Drug-Induced Liver Injury [Internet]-Abemaciclib. DM93VBZ RU https://www.ncbi.nlm.nih.gov/books/NBK548807/ DM93VBZ DI DM93VBZ DM93VBZ DN LY2835219 DM93VBZ MI DTZGT0P DM93VBZ MN Multidrug and toxin extrusion protein 1 (SLC47A1) DM93VBZ MT DTP DM93VBZ MA Substrate DM93VBZ RN Abemaciclib Inhibits Renal Tubular Secretion Without Changing Glomerular Filtration Rate. Clin Pharmacol Ther. 2019 May;105(5):1187-1195. DM93VBZ RU http://www.ncbi.nlm.nih.gov/pubmed/30449032 DM93VBZ DI DM93VBZ DM93VBZ DN LY2835219 DM93VBZ MI DT3TX4H DM93VBZ MN Multidrug and toxin extrusion protein 2 (SLC47A2) DM93VBZ MT DTP DM93VBZ MA Substrate DM93VBZ RN Abemaciclib Inhibits Renal Tubular Secretion Without Changing Glomerular Filtration Rate. Clin Pharmacol Ther. 2019 May;105(5):1187-1195. DM93VBZ RU http://www.ncbi.nlm.nih.gov/pubmed/30449032 DM93VBZ DI DM93VBZ DM93VBZ DN LY2835219 DM93VBZ MI DT9IDPW DM93VBZ MN Organic cation transporter 2 (SLC22A2) DM93VBZ MT DTP DM93VBZ MA Substrate DM93VBZ RN Abemaciclib Inhibits Renal Tubular Secretion Without Changing Glomerular Filtration Rate. Clin Pharmacol Ther. 2019 May;105(5):1187-1195. DM93VBZ RU http://www.ncbi.nlm.nih.gov/pubmed/30449032 DMOMLHJ DI DMOMLHJ DMOMLHJ DN Lymecycline DMOMLHJ MI TTQ8KVI DMOMLHJ MN Staphylococcus 30S ribosomal subunit (Stap-coc pbp2) DMOMLHJ MT DTT DMOMLHJ MA Binder DMOMLHJ RN Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. DMOMLHJ RU https://pubmed.ncbi.nlm.nih.gov/17016423 DM154EB DI DM154EB DM154EB DN Lypressin DM154EB MI TTPFZJ1 DM154EB MN Vasopressin V1 receptor (V1R) DM154EB MT DTT DM154EB MA Modulator DM154EB RN Human pain thresholds after the application of lypressin, a vasopressin analogue. Pharmacol Toxicol. 1987 Jul;61(1):16-9. DM154EB RU https://pubmed.ncbi.nlm.nih.gov/3628176 DMQYJIR DI DMQYJIR DMQYJIR DN Macimorelin DMQYJIR MI TTWDC17 DMQYJIR MN Growth hormone secretagogue receptor 1 (GHSR) DMQYJIR MT DTT DMQYJIR MA Agonist DMQYJIR RN National Cancer Institute Drug Dictionary (drug id 735530). DMQYJIR RU http://www.cancer.gov/publications/dictionaries/cancer-drug?cdrid=735530 DMP79A1 DI DMP79A1 DMP79A1 DN Macitentan DMP79A1 MI DE4LYSA DMP79A1 MN Cytochrome P450 3A4 (CYP3A4) DMP79A1 MT DME DMP79A1 MA Metabolism DMP79A1 RN Investigation of the effects of ketoconazole on the pharmacokinetics of macitentan, a novel dual endothelin receptor antagonist, in healthy subjects. Clin Pharmacokinet. 2013 Aug;52(8):685-92. DMP79A1 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=23568224 DMP79A1 DI DMP79A1 DMP79A1 DN Macitentan DMP79A1 MI TTKRD0G DMP79A1 MN Endothelin A receptor (EDNRA) DMP79A1 MT DTT DMP79A1 MA Modulator DMP79A1 RN Radium 223 dichloride for prostate cancer treatment. Drug Des Devel Ther. 2017 Sep 6;11:2643-2651. DMP79A1 RU https://pubmed.ncbi.nlm.nih.gov/28919714 DMP79A1 DI DMP79A1 DMP79A1 DN Macitentan DMP79A1 MI TT3ZTGU DMP79A1 MN Endothelin B receptor (EDNRB) DMP79A1 MT DTT DMP79A1 MA Modulator DMP79A1 RN Radium 223 dichloride for prostate cancer treatment. Drug Des Devel Ther. 2017 Sep 6;11:2643-2651. DMP79A1 RU https://pubmed.ncbi.nlm.nih.gov/28919714 DMP79A1 DI DMP79A1 DMP79A1 DN Macitentan DMP79A1 MI DEGTFWK DMP79A1 MN Mephenytoin 4-hydroxylase (CYP2C19) DMP79A1 MT DME DMP79A1 MA Metabolism DMP79A1 RN Investigation of the effects of ketoconazole on the pharmacokinetics of macitentan, a novel dual endothelin receptor antagonist, in healthy subjects. Clin Pharmacokinet. 2013 Aug;52(8):685-92. DMP79A1 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=23568224 DM3BS97 DI DM3BS97 DM3BS97 DN Macrolides DM3BS97 MI TTLFGBV DM3BS97 MN Bacterial 23S ribosomal RNA (Bact 23S rRNA) DM3BS97 MT DTT DM3BS97 MA Binder DM3BS97 RN Has nature already identified all useful antibacterial targets Curr Opin Microbiol. 2008 Oct;11(5):387-92. DM3BS97 RU https://pubmed.ncbi.nlm.nih.gov/18804175 DMU4ORS DI DMU4ORS DMU4ORS DN Magnesium DMU4ORS MI TT9IK2Z DMU4ORS MN N-methyl-D-aspartate receptor (NMDAR) DMU4ORS MT DTT DMU4ORS MA Antagonist DMU4ORS RN Emerging drugs for acute ischemic stroke. Expert Opin Emerg Drugs. 2009 Mar;14(1):33-42. DMU4ORS RU https://pubmed.ncbi.nlm.nih.gov/19249986 DMVEK07 DI DMVEK07 DMVEK07 DN Magnesium Sulfate DMVEK07 MI TT9IK2Z DMVEK07 MN N-methyl-D-aspartate receptor (NMDAR) DMVEK07 MT DTT DMVEK07 MA Antagonist DMVEK07 RN Magnesium sulfate diminishes the effects of amide local anesthetics in rat sciatic-nerve block. Reg Anesth Pain Med. 2007 Jul-Aug;32(4):288-95. DMVEK07 RU https://pubmed.ncbi.nlm.nih.gov/17720112 DMXZ84M DI DMXZ84M DMXZ84M DN Malathion DMXZ84M MI TT1RS9F DMXZ84M MN Acetylcholinesterase (AChE) DMXZ84M MT DTT DMXZ84M MA Inhibitor DMXZ84M RN Acetylcholinesterase activity in Corbicula fluminea Mull., as a biomarker of organophosphate pesticide pollution in Pinacanauan River, Philippines. Environ Monit Assess. 2010 Jun;165(1-4):331-40. DMXZ84M RU https://pubmed.ncbi.nlm.nih.gov/19444631 DMXZ84M DI DMXZ84M DMXZ84M DN Malathion DMXZ84M MI DEJGDUW DMXZ84M MN Cytochrome P450 1A2 (CYP1A2) DMXZ84M MT DME DMXZ84M MA Metabolism DMXZ84M RN Malathion bioactivation in the human liver: the contribution of different cytochrome p450 isoforms. Drug Metab Dispos. 2005 Mar;33(3):295-302. DMXZ84M RU https://www.ncbi.nlm.nih.gov/pubmed/?term=15557345 DMXZ84M DI DMXZ84M DMXZ84M DN Malathion DMXZ84M MI DEPKLMQ DMXZ84M MN Cytochrome P450 2B6 (CYP2B6) DMXZ84M MT DME DMXZ84M MA Metabolism DMXZ84M RN Malathion bioactivation in the human liver: the contribution of different cytochrome p450 isoforms. Drug Metab Dispos. 2005 Mar;33(3):295-302. DMXZ84M RU https://www.ncbi.nlm.nih.gov/pubmed/?term=15557345 DMSCDY9 DI DMSCDY9 DMSCDY9 DN Mannitol DMSCDY9 MI TTTX5M8 DMSCDY9 MN Aspergillus Mannitol 2-dehydrogenase (Asperg M2DH) DMSCDY9 MT DTT DMSCDY9 MA Activator DMSCDY9 RN Polyol-specific long-chain dehydrogenases/reductases of mannitol metabolism in Aspergillus fumigatus: biochemical characterization and pH studies o... Chem Biol Interact. 2009 Mar 16;178(1-3):274-82. DMSCDY9 RU https://pubmed.ncbi.nlm.nih.gov/18983992 DMSCDY9 DI DMSCDY9 DMSCDY9 DN Mannitol DMSCDY9 MI TTV0PE2 DMSCDY9 MN Aspergillus Mannitol-1-phosphate 5-dehydrogenase (Asperg mpdA) DMSCDY9 MT DTT DMSCDY9 MA Activator DMSCDY9 RN Polyol-specific long-chain dehydrogenases/reductases of mannitol metabolism in Aspergillus fumigatus: biochemical characterization and pH studies o... Chem Biol Interact. 2009 Mar 16;178(1-3):274-82. DMSCDY9 RU https://pubmed.ncbi.nlm.nih.gov/18983992 DMPWB7T DI DMPWB7T DMPWB7T DN Maprotiline DMPWB7T MI DEJGDUW DMPWB7T MN Cytochrome P450 1A2 (CYP1A2) DMPWB7T MT DME DMPWB7T MA Metabolism DMPWB7T RN Cytochrome P450 enzymes contributing to demethylation of maprotiline in man. Pharmacol Toxicol. 2002 Mar;90(3):144-9. DMPWB7T RU https://www.ncbi.nlm.nih.gov/pubmed/?term=12071336 DMPWB7T DI DMPWB7T DMPWB7T DN Maprotiline DMPWB7T MI DECB0K3 DMPWB7T MN Cytochrome P450 2D6 (CYP2D6) DMPWB7T MT DME DMPWB7T MA Metabolism DMPWB7T RN Cytochrome P450 enzymes contributing to demethylation of maprotiline in man. Pharmacol Toxicol. 2002 Mar;90(3):144-9. DMPWB7T RU https://www.ncbi.nlm.nih.gov/pubmed/?term=12071336 DMPWB7T DI DMPWB7T DMPWB7T DN Maprotiline DMPWB7T MI TTAWNKZ DMPWB7T MN Norepinephrine transporter (NET) DMPWB7T MT DTT DMPWB7T MA Inhibitor DMPWB7T RN Effect of pharmacologically selective antidepressants on serotonin uptake in rat platelets. Gen Physiol Biophys. 2005 Mar;24(1):113-28. DMPWB7T RU https://pubmed.ncbi.nlm.nih.gov/15900091 DMTL94F DI DMTL94F DMTL94F DN Maraviroc DMTL94F MI TT2CEJG DMTL94F MN C-C chemokine receptor type 5 (CCR5) DMTL94F MT DTT DMTL94F MA Antagonist DMTL94F RN Rapamycin enhances aplaviroc anti-HIV activity: implications for the clinical development of novel CCR5 antagonists. Antiviral Res. 2009 Jul;83(1):86-9. DMTL94F RU https://pubmed.ncbi.nlm.nih.gov/19501260 DMTL94F DI DMTL94F DMTL94F DN Maraviroc DMTL94F MI TTJIH8Q DMTL94F MN CCR5 messenger RNA (CCR5 mRNA) DMTL94F MT DTT DMTL94F MA Antagonist DMTL94F RN Molecular cloning and radioligand binding characterization of the chemokine receptor CCR5 from rhesus macaque and human. Biochem Pharmacol. 2005 Dec 19;71(1-2):163-72. DMTL94F RU https://pubmed.ncbi.nlm.nih.gov/16298345 DMTL94F DI DMTL94F DMTL94F DN Maraviroc DMTL94F MI DTUGYRD DMTL94F MN P-glycoprotein 1 (ABCB1) DMTL94F MT DTP DMTL94F MA Substrate DMTL94F RN Tarascon Pocket Pharmacopoeia 2018 Classic Shirt-Pocket Edition. DMTL94F RU https://books.google.com/books?id=0gBRDwAAQBAJ&pg=PP37&lpg=PP37&dq=Methylergonovine+transporter+uptake+efflex&source=bl&ots=cUTe_ppsmZ&sig=ACfU3U3E_YqrDg0CNEuj8K-7lci47HAnrg&hl=zh-CN&sa=X&ved=2ahUKEwjnj-Dk7d7iAhUsK6YKHd5DBDkQ6AEwEnoECAgQAQ#v=onepage&q&f=false DMKEY6S DI DMKEY6S DMKEY6S DN Margetuximab DMKEY6S MI TT6EO5L DMKEY6S MN Erbb2 tyrosine kinase receptor (HER2) DMKEY6S MT DTT DMKEY6S RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health Human Services. 2020 DMKEY6S RU https://www.accessdata.fda.gov/drugsatfda_docs/label/2020/761150s000lbl.pdf DM70IK5 DI DM70IK5 DM70IK5 DN Marinol DM70IK5 MI TT6OEDT DM70IK5 MN Cannabinoid receptor 1 (CB1) DM70IK5 MT DTT DM70IK5 MA Agonist DM70IK5 RN Emerging strategies for exploiting cannabinoid receptor agonists as medicines. Br J Pharmacol. 2009 Feb;156(3):397-411. DM70IK5 RU https://pubmed.ncbi.nlm.nih.gov/19226257 DM70IK5 DI DM70IK5 DM70IK5 DN Marinol DM70IK5 MI DE6OQ3W DM70IK5 MN Cytochrome P450 1A1 (CYP1A1) DM70IK5 MT DME DM70IK5 MA Metabolism DM70IK5 RN Increasing the intracellular availability of all-trans retinoic acid in neuroblastoma cells. Br J Cancer. 2005 Feb 28;92(4):696-704. DM70IK5 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=15714209 DM70IK5 DI DM70IK5 DM70IK5 DN Marinol DM70IK5 MI DEJVYAZ DM70IK5 MN Cytochrome P450 2A6 (CYP2A6) DM70IK5 MT DME DM70IK5 MA Metabolism DM70IK5 RN Health control over the feeding of troops on the Western and 3d Belorussian Fronts during the Great Patriotic War years. Voen Med Zh. 1975 Jun;(6):86-8. DM70IK5 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=1103455 DM70IK5 DI DM70IK5 DM70IK5 DN Marinol DM70IK5 MI DE5IED8 DM70IK5 MN Cytochrome P450 2C9 (CYP2C9) DM70IK5 MT DME DM70IK5 MA Metabolism DM70IK5 RN CYP2C-catalyzed delta9-tetrahydrocannabinol metabolism: kinetics, pharmacogenetics and interaction with phenytoin. Biochem Pharmacol. 2005 Oct 1;70(7):1096-103. DM70IK5 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=16112652 DM70IK5 DI DM70IK5 DM70IK5 DN Marinol DM70IK5 MI DE4LYSA DM70IK5 MN Cytochrome P450 3A4 (CYP3A4) DM70IK5 MT DME DM70IK5 MA Metabolism DM70IK5 RN Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. DM70IK5 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=19515014 DM70IK5 DI DM70IK5 DM70IK5 DN Marinol DM70IK5 MI DEGTFWK DM70IK5 MN Mephenytoin 4-hydroxylase (CYP2C19) DM70IK5 MT DME DM70IK5 MA Metabolism DM70IK5 RN Inhibition of cyclosporine and tetrahydrocannabinol metabolism by cannabidiol in mouse and human microsomes. Xenobiotica. 1996 Mar;26(3):275-84. DM70IK5 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=8730919 DM70IK5 DI DM70IK5 DM70IK5 DN Marinol DM70IK5 MI DE073H6 DM70IK5 MN Prostaglandin G/H synthase 1 (COX-1) DM70IK5 MT DME DM70IK5 MA Metabolism DM70IK5 RN Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. DM70IK5 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=19515014 DMMVNZ0 DI DMMVNZ0 DMMVNZ0 DN Masoprocol DMMVNZ0 MI TT6EO5L DMMVNZ0 MN Erbb2 tyrosine kinase receptor (HER2) DMMVNZ0 MT DTT DMMVNZ0 MA Modulator DMMVNZ0 RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. DMMVNZ0 RU https://www.fda.gov/ DMZ36RN DI DMZ36RN DMZ36RN DN Mazindol DMZ36RN MI TTAWNKZ DMZ36RN MN Norepinephrine transporter (NET) DMZ36RN MT DTT DMZ36RN MA Modulator DMZ36RN RN Binding of [3H]mazindol to cardiac norepinephrine transporters: kinetic and equilibrium studies. Naunyn Schmiedebergs Arch Pharmacol. 2004 Jul;370(1):9-16. DMZ36RN RU https://pubmed.ncbi.nlm.nih.gov/15300361 DM0R4Z5 DI DM0R4Z5 DM0R4Z5 DN MCB-3837 DM0R4Z5 MI TT9SL3Q DM0R4Z5 MN Polypeptide deformylase (PDF) DM0R4Z5 MT DTT DM0R4Z5 MA Inhibitor DM0R4Z5 RN The fight against drug-resistant malaria: novel plasmodial targets and antimalarial drugs. Curr Med Chem. 2008;15(2):161-71. DM0R4Z5 RU https://pubmed.ncbi.nlm.nih.gov/18220771 DM8ZHP1 DI DM8ZHP1 DM8ZHP1 DN MCI-186 DM8ZHP1 MI TTJGNVC DM8ZHP1 MN Apoptosis regulator Bcl-2 (BCL-2) DM8ZHP1 MT DTT DM8ZHP1 MA Regulator (upregulator) DM8ZHP1 RN Emerging disease-modifying therapies for the treatment of motor neuron disease/amyotropic lateral sclerosis. Expert Opin Emerg Drugs. 2007 May;12(2):229-52. DM8ZHP1 RU https://pubmed.ncbi.nlm.nih.gov/17604499 DM8ZHP1 DI DM8ZHP1 DM8ZHP1 DN MCI-186 DM8ZHP1 MI DTQ23VB DM8ZHP1 MN Organic anion transporter 1 (SLC22A6) DM8ZHP1 MT DTP DM8ZHP1 MA Substrate DM8ZHP1 RN Human organic anion transporters 1 (hOAT1/SLC22A6) and 3 (hOAT3/SLC22A8) transport edaravone (MCI-186; 3-methyl-1-phenyl-2-pyrazolin-5-one) and its sulfate conjugate. Drug Metab Dispos. 2007 Aug;35(8):1429-34. DM8ZHP1 RU http://www.ncbi.nlm.nih.gov/pubmed/17502342 DM8ZHP1 DI DM8ZHP1 DM8ZHP1 DN MCI-186 DM8ZHP1 MI DTVP67E DM8ZHP1 MN Organic anion transporter 3 (SLC22A8) DM8ZHP1 MT DTP DM8ZHP1 MA Substrate DM8ZHP1 RN Human organic anion transporters 1 (hOAT1/SLC22A6) and 3 (hOAT3/SLC22A8) transport edaravone (MCI-186; 3-methyl-1-phenyl-2-pyrazolin-5-one) and its sulfate conjugate. Drug Metab Dispos. 2007 Aug;35(8):1429-34. DM8ZHP1 RU http://www.ncbi.nlm.nih.gov/pubmed/17502342 DM8ZHP1 DI DM8ZHP1 DM8ZHP1 DN MCI-186 DM8ZHP1 MI DEYGVN4 DM8ZHP1 MN UDP-glucuronosyltransferase 1A1 (UGT1A1) DM8ZHP1 MT DME DM8ZHP1 MA Metabolism DM8ZHP1 RN A novel administration route for edaravone: I. Effects of metabolic inhibitors on skin permeability of edaravone. Int J Pharm. 2009 May 8;372(1-2):33-8. DM8ZHP1 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=19166920 DM4IAKR DI DM4IAKR DM4IAKR DN MD-1100 DM4IAKR MI TTLDPRG DM4IAKR MN Guanylyl cyclase C (GUCY2C) DM4IAKR MT DTT DM4IAKR MA Activator DM4IAKR RN Emerging drugs for irritable bowel syndrome. Expert Opin Emerg Drugs. 2006 May;11(2):293-313. DM4IAKR RU https://pubmed.ncbi.nlm.nih.gov/16634703 DMO14SG DI DMO14SG DMO14SG DN Mebendazole DMO14SG MI DE4LYSA DMO14SG MN Cytochrome P450 3A4 (CYP3A4) DMO14SG MT DME DMO14SG MA Metabolism DMO14SG RN Alveolar echinococcosis of the liver in an adult with human immunodeficiency virus type-1 infection. Infection. 2004 Oct;32(5):299-302. DMO14SG RU https://www.ncbi.nlm.nih.gov/pubmed/?term=15624896 DMO14SG DI DMO14SG DMO14SG DN Mebendazole DMO14SG MI TTYFKSZ DMO14SG MN Tubulin beta (TUBB) DMO14SG MT DTT DMO14SG MA Binder DMO14SG RN Flubendazole interferes with a wide spectrum of cell homeostatic mechanisms in Echinococcus granulosus protoscoleces. Parasitol Int. 2009 Sep;58(3):270-7. DMO14SG RU https://pubmed.ncbi.nlm.nih.gov/19336257 DMNOBFQ DI DMNOBFQ DMNOBFQ DN Mebeverine DMNOBFQ MI TTH18TF DMNOBFQ MN Muscarinic acetylcholine receptor M5 (CHRM5) DMNOBFQ MT DTT DMNOBFQ MA Antagonist DMNOBFQ RN Emerging drugs for irritable bowel syndrome. Expert Opin Emerg Drugs. 2006 May;11(2):293-313. DMNOBFQ RU https://pubmed.ncbi.nlm.nih.gov/16634703 DM0KYI4 DI DM0KYI4 DM0KYI4 DN Mebutamate DM0KYI4 MI TTEX6LM DM0KYI4 MN GABA(A) receptor gamma-3 (GABRG3) DM0KYI4 MT DTT DM0KYI4 MA Modulator DM0KYI4 RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. DM0KYI4 RU https://www.fda.gov/ DMGQFYB DI DMGQFYB DMGQFYB DN Mecamylamine DMGQFYB MI TTJSZTB DMGQFYB MN Nicotinic acetylcholine receptor (nAChR) DMGQFYB MT DTT DMGQFYB MA Antagonist DMGQFYB RN Mecamylamine (Inversine): an old antihypertensive with new research directions. J Hum Hypertens. 2002 Jul;16(7):453-7. DMGQFYB RU https://pubmed.ncbi.nlm.nih.gov/12080428 DM1O3BY DI DM1O3BY DM1O3BY DN Mecasermin DM1O3BY MI TTHRID2 DM1O3BY MN Insulin-like growth factor I receptor (IGF1R) DM1O3BY MT DTT DM1O3BY MA Inhibitor DM1O3BY RN IGF-1R, IGF-1 and IGF-2 expression as potential prognostic and predictive markers in colorectal-cancer. Virchows Arch. 2003 Aug;443(2):139-45. DM1O3BY RU https://pubmed.ncbi.nlm.nih.gov/12845531 DM0CVXA DI DM0CVXA DM0CVXA DN Mechlorethamine DM0CVXA MI TTUTN1I DM0CVXA MN Human Deoxyribonucleic acid (hDNA) DM0CVXA MT DTT DM0CVXA MA Intercalator DM0CVXA RN Proteomic analysis of DNA-protein cross-linking by antitumor nitrogen mustards. Chem Res Toxicol. 2009 Jun;22(6):1151-62. DM0CVXA RU https://pubmed.ncbi.nlm.nih.gov/19480393 DMS7T13 DI DMS7T13 DMS7T13 DN Meclizine DMS7T13 MI DECB0K3 DMS7T13 MN Cytochrome P450 2D6 (CYP2D6) DMS7T13 MT DME DMS7T13 MA Metabolism DMS7T13 RN Meclizine metabolism and pharmacokinetics: formulation on its absorption. J Clin Pharmacol. 2012 Sep;52(9):1343-9. DMS7T13 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=21903894 DMS7T13 DI DMS7T13 DMS7T13 DN Meclizine DMS7T13 MI TTRANFM DMS7T13 MN Orphan nuclear receptor NR1I3 (NR1I3) DMS7T13 MT DTT DMS7T13 MA Modulator DMS7T13 RN Synthetic drugs and natural products as modulators of constitutive androstane receptor (CAR) and pregnane X receptor (PXR). Drug Metab Rev. 2006;38(1-2):51-73. DMS7T13 RU https://pubmed.ncbi.nlm.nih.gov/16684648 DMSFQ8I DI DMSFQ8I DMSFQ8I DN Meclocycline DMSFQ8I MI TTQ8KVI DMSFQ8I MN Staphylococcus 30S ribosomal subunit (Stap-coc pbp2) DMSFQ8I MT DTT DMSFQ8I MA Binder DMSFQ8I RN Detection of tetracycline resistance genes by PCR methods. Methods Mol Biol. 2004;268:3-13. DMSFQ8I RU https://pubmed.ncbi.nlm.nih.gov/15156014 DMNL98G DI DMNL98G DMNL98G DN Meclofenamate sodium DMNL98G MI TT8NGED DMNL98G MN Prostaglandin G/H synthase 1 (COX-1) DMNL98G MT DTT DMNL98G MA Modulator DMNL98G RN Role of COX-2-derived metabolites in regulation of the renal hemodynamic response to norepinephrine. Am J Physiol Renal Physiol. 2001 Nov;281(5):F975-82. DMNL98G RU https://www.ncbi.nlm.nih.gov/pubmed/11592955 DMNL98G DI DMNL98G DMNL98G DN Meclofenamate sodium DMNL98G MI TTVKILB DMNL98G MN Prostaglandin G/H synthase 2 (COX-2) DMNL98G MT DTT DMNL98G MA Modulator DMNL98G RN Role of COX-2-derived metabolites in regulation of the renal hemodynamic response to norepinephrine. Am J Physiol Renal Physiol. 2001 Nov;281(5):F975-82. DMNL98G RU https://www.ncbi.nlm.nih.gov/pubmed/11592955 DM05FXR DI DM05FXR DM05FXR DN Meclofenamic acid DM05FXR MI DE4OGUF DM05FXR MN Cytochrome P450 102A1 (cyp102) DM05FXR MT DME DM05FXR MA Metabolism DM05FXR RN Both reactivity and accessibility are important in cytochrome P450 metabolism: a combined DFT and MD study of fenamic acids in BM3 mutants. J Chem Inf Model. 2019 Feb 25;59(2):743-753. DM05FXR RU https://pubmed.ncbi.nlm.nih.gov/30758202 DM05FXR DI DM05FXR DM05FXR DN Meclofenamic acid DM05FXR MI TTK0943 DM05FXR MN Prostaglandin G/H synthase (COX) DM05FXR MT DTT DM05FXR MA Inhibitor DM05FXR RN Interactions of PGH synthase isozymes-1 and -2 with NSAIDs. Ann N Y Acad Sci. 1994 Nov 15;744:50-7. DM05FXR RU https://pubmed.ncbi.nlm.nih.gov/7825862 DMBGWPH DI DMBGWPH DMBGWPH DN Medroxyprogesterone DMBGWPH MI DE4LYSA DMBGWPH MN Cytochrome P450 3A4 (CYP3A4) DMBGWPH MT DME DMBGWPH MA Metabolism DMBGWPH RN Metabolic profiling and cytochrome P450 reaction phenotyping of medroxyprogesterone acetate. Drug Metab Dispos. 2008 Nov;36(11):2292-8. DMBGWPH RU https://www.ncbi.nlm.nih.gov/pubmed/?term=18725509 DMBGWPH DI DMBGWPH DMBGWPH DN Medroxyprogesterone DMBGWPH MI TTUV8G9 DMBGWPH MN Progesterone receptor (PGR) DMBGWPH MT DTT DMBGWPH MA Agonist DMBGWPH RN Dienogest is a selective progesterone receptor agonist in transactivation analysis with potent oral endometrial activity due to its efficient pharm... Steroids. 2008 Feb;73(2):222-31. DMBGWPH RU https://pubmed.ncbi.nlm.nih.gov/18061638 DMJ90O5 DI DMJ90O5 DMJ90O5 DN Medrysone DMJ90O5 MI DE4LYSA DMJ90O5 MN Cytochrome P450 3A4 (CYP3A4) DMJ90O5 MT DME DMJ90O5 MA Metabolism DMJ90O5 RN Regulation of drug-metabolizing cytochrome P450 enzymes by glucocorticoids. Drug Metab Rev. 2010 Nov;42(4):621-35. DMJ90O5 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=20482443 DMJ90O5 DI DMJ90O5 DMJ90O5 DN Medrysone DMJ90O5 MI TTP3UTW DMJ90O5 MN Steroid hormone receptor ERR (ESRR) DMJ90O5 MT DTT DMJ90O5 MA Modulator DMJ90O5 RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. DMJ90O5 RU https://www.fda.gov/ DMK7HFI DI DMK7HFI DMK7HFI DN Mefenamic acid DMK7HFI MI DE4OGUF DMK7HFI MN Cytochrome P450 102A1 (cyp102) DMK7HFI MT DME DMK7HFI MA Metabolism DMK7HFI RN Both reactivity and accessibility are important in cytochrome P450 metabolism: a combined DFT and MD study of fenamic acids in BM3 mutants. J Chem Inf Model. 2019 Feb 25;59(2):743-753. DMK7HFI RU https://pubmed.ncbi.nlm.nih.gov/30758202 DMK7HFI DI DMK7HFI DMK7HFI DN Mefenamic acid DMK7HFI MI DES5XRU DMK7HFI MN Cytochrome P450 2C8 (CYP2C8) DMK7HFI MT DME DMK7HFI MA Metabolism DMK7HFI RN Role of cytochrome P450 2C8 in drug metabolism and interactions. Pharmacol Rev. 2016 Jan;68(1):168-241. DMK7HFI RU https://www.ncbi.nlm.nih.gov/pubmed/?term=26721703 DMK7HFI DI DMK7HFI DMK7HFI DN Mefenamic acid DMK7HFI MI DE5IED8 DMK7HFI MN Cytochrome P450 2C9 (CYP2C9) DMK7HFI MT DME DMK7HFI MA Metabolism DMK7HFI RN Cytochrome P450-mediated bioactivation of mefenamic acid to quinoneimine intermediates and inactivation by human glutathione S-transferases. Chem Res Toxicol. 2014 Dec 15;27(12):2071-81. DMK7HFI RU https://www.ncbi.nlm.nih.gov/pubmed/?term=25372302 DMK7HFI DI DMK7HFI DMK7HFI DN Mefenamic acid DMK7HFI MI TTVKILB DMK7HFI MN Prostaglandin G/H synthase 2 (COX-2) DMK7HFI MT DTT DMK7HFI MA Inhibitor DMK7HFI RN Systematic pharmacological approach to the characterization of NSAIDs. Prostaglandins Leukot Essent Fatty Acids. 1998 Jul;59(1):55-62. DMK7HFI RU https://pubmed.ncbi.nlm.nih.gov/9758208 DMWT905 DI DMWT905 DMWT905 DN Mefloquine DMWT905 MI DE4LYSA DMWT905 MN Cytochrome P450 3A4 (CYP3A4) DMWT905 MT DME DMWT905 MA Metabolism DMWT905 RN Effect of rifampin on plasma concentrations of mefloquine in healthy volunteers. J Pharm Pharmacol. 2000 Oct;52(10):1265-9. DMWT905 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=11092571 DMWT905 DI DMWT905 DMWT905 DN Mefloquine DMWT905 MI DTUGYRD DMWT905 MN P-glycoprotein 1 (ABCB1) DMWT905 MT DTP DMWT905 MA Substrate DMWT905 RN Polymorphisms in human MDR1 (P-glycoprotein): recent advances and clinical relevance. Clin Pharmacol Ther. 2004 Jan;75(1):13-33. DMWT905 RU https://doi.org/10.1016/j.clpt.2003.09.012 DMWT905 DI DMWT905 DMWT905 DN Mefloquine DMWT905 MI TTT28H3 DMWT905 MN Plasmodium 80S ribosome (Malaria 80S) DMWT905 MT DTT DMWT905 MA Binder DMWT905 RN An ultrastructural study of the effects of mefloquine on malaria parasites. Am J Trop Med Hyg. 1987 Jan;36(1):9-14. DMWT905 RU https://pubmed.ncbi.nlm.nih.gov/3544894 DMDH9KX DI DMDH9KX DMDH9KX DN Megestrol DMDH9KX MI DE4LYSA DMDH9KX MN Cytochrome P450 3A4 (CYP3A4) DMDH9KX MT DME DMDH9KX MA Metabolism DMDH9KX RN Metabolism of megestrol acetate in vitro and the role of oxidative metabolites. Xenobiotica. 2018 Oct;48(10):973-983. DMDH9KX RU https://www.ncbi.nlm.nih.gov/pubmed/?term=29050522 DMDH9KX DI DMDH9KX DMDH9KX DN Megestrol DMDH9KX MI TTUV8G9 DMDH9KX MN Progesterone receptor (PGR) DMDH9KX MT DTT DMDH9KX MA Binder DMDH9KX RN Focus on anastrozole and breast cancer. Curr Med Res Opin. 2003;19(8):683-8. DMDH9KX RU https://pubmed.ncbi.nlm.nih.gov/14687437 DM1OFHN DI DM1OFHN DM1OFHN DN Meglitinides DM1OFHN MI TTEX248 DM1OFHN MN Dopamine D2 receptor (D2R) DM1OFHN MT DTT DM1OFHN MA Antagonist DM1OFHN RN Specific in vitro and in vivo binding of 3H-raclopride. A potent substituted benzamide drug with high affinity for dopamine D-2 receptors in the rat brain. Biochem Pharmacol. 1985 Jul 1;34(13):2251-9. DM1OFHN RU https://pubmed.ncbi.nlm.nih.gov/4015674 DM1OFHN DI DM1OFHN DM1OFHN DN Meglitinides DM1OFHN MI TTCBFJO DM1OFHN MN Insulin receptor (INSR) DM1OFHN MT DTT DM1OFHN MA Stimulator DM1OFHN RN New drugs for type 2 diabetes mellitus: what is their place in therapy Drugs. 2008;68(15):2131-62. DM1OFHN RU https://pubmed.ncbi.nlm.nih.gov/18840004 DMGUZ0W DI DMGUZ0W DMGUZ0W DN MELARSOPROL DMGUZ0W MI TT2SUAQ DMGUZ0W MN Cysteine protease (CYP) DMGUZ0W MT DTT DMGUZ0W MA Inhibitor DMGUZ0W RN On-bead screening of a combinatorial fumaric acid derived peptide library yields antiplasmodial cysteine protease inhibitors with unusual peptide s... J Med Chem. 2009 Sep 24;52(18):5662-72. DMGUZ0W RU https://pubmed.ncbi.nlm.nih.gov/19715342 DMKWFBT DI DMKWFBT DMKWFBT DN Melatonin DMKWFBT MI DE6OQ3W DMKWFBT MN Cytochrome P450 1A1 (CYP1A1) DMKWFBT MT DME DMKWFBT MA Metabolism DMKWFBT RN Metabolism of melatonin by human cytochromes p450. Drug Metab Dispos. 2005 Apr;33(4):489-94. DMKWFBT RU https://www.ncbi.nlm.nih.gov/pubmed/?term=15616152 DMKWFBT DI DMKWFBT DMKWFBT DN Melatonin DMKWFBT MI DEJGDUW DMKWFBT MN Cytochrome P450 1A2 (CYP1A2) DMKWFBT MT DME DMKWFBT MA Metabolism DMKWFBT RN Multiple P450 substrates in a single run: rapid and comprehensive in vitro interaction assay. Eur J Pharm Sci. 2005 Jan;24(1):123-32. DMKWFBT RU https://www.ncbi.nlm.nih.gov/pubmed/?term=15626586 DMKWFBT DI DMKWFBT DMKWFBT DN Melatonin DMKWFBT MI DE9QHP6 DMKWFBT MN Cytochrome P450 1B1 (CYP1B1) DMKWFBT MT DME DMKWFBT MA Metabolism DMKWFBT RN Metabolism of melatonin by human cytochromes p450. Drug Metab Dispos. 2005 Apr;33(4):489-94. DMKWFBT RU https://www.ncbi.nlm.nih.gov/pubmed/?term=15616152 DMKWFBT DI DMKWFBT DMKWFBT DN Melatonin DMKWFBT MI DE5IED8 DMKWFBT MN Cytochrome P450 2C9 (CYP2C9) DMKWFBT MT DME DMKWFBT MA Metabolism DMKWFBT RN New insights into the structural features and functional relevance of human cytochrome P450 2C9. Part I. Curr Drug Metab. 2009 Dec;10(10):1075-126. DMKWFBT RU https://www.ncbi.nlm.nih.gov/pubmed/?term=20167001 DMKWFBT DI DMKWFBT DMKWFBT DN Melatonin DMKWFBT MI DEHGR57 DMKWFBT MN Hydroxyindole O-methyltransferase (ASMT) DMKWFBT MT DME DMKWFBT MA Metabolism DMKWFBT RN The pharmacology of the pineal gland. Annu Rev Pharmacol Toxicol. 1976;16:33-51. DMKWFBT RU https://www.ncbi.nlm.nih.gov/pubmed/?term=180879 DMKWFBT DI DMKWFBT DMKWFBT DN Melatonin DMKWFBT MI DE43MW5 DMKWFBT MN Indoleamine 2,3-dioxygenase 1 (IDO1) DMKWFBT MT DME DMKWFBT MA Metabolism DMKWFBT RN Molecular evidence that melatonin is enzymatically oxidized in a different manner than tryptophan: investigations with both indoleamine 2,3-dioxygenase and myeloperoxidase. Biochem J. 2005 May 15;388(Pt 1):205-15. DMKWFBT RU https://www.ncbi.nlm.nih.gov/pubmed/?term=15636586 DMKWFBT DI DMKWFBT DMKWFBT DN Melatonin DMKWFBT MI TT0WAIE DMKWFBT MN Melatonin receptor type 1A (MTNR1A) DMKWFBT MT DTT DMKWFBT MA Binder DMKWFBT RN The human MT1 melatonin receptor stimulates cAMP production in the human neuroblastoma cell line SH-SY5Y cells via a calcium-calmodulin signal transduction pathway. J Neuroendocrinol. 2005 Mar;17(3):170-8. DMKWFBT RU https://pubmed.ncbi.nlm.nih.gov/15796769 DMKWFBT DI DMKWFBT DMKWFBT DN Melatonin DMKWFBT MI DEGTFWK DMKWFBT MN Mephenytoin 4-hydroxylase (CYP2C19) DMKWFBT MT DME DMKWFBT MA Metabolism DMKWFBT RN The effect of CYP2C19 substrate on the metabolism of melatonin in the elderly: a randomized, double-blind, placebo-controlled study. Methods Find Exp Clin Pharmacol. 2006 Sep;28(7):447-50. DMKWFBT RU https://www.ncbi.nlm.nih.gov/pubmed/?term=17003850 DMKWFBT DI DMKWFBT DMKWFBT DN Melatonin DMKWFBT MI TTJLP0R DMKWFBT MN Quinone reductase 2 (NQO2) DMKWFBT MT DTT DMKWFBT MA Inhibitor DMKWFBT RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DMKWFBT RU https://pubmed.ncbi.nlm.nih.gov/10592235 DM2AR7L DI DM2AR7L DM2AR7L DN Meloxicam DM2AR7L MI DES5XRU DM2AR7L MN Cytochrome P450 2C8 (CYP2C8) DM2AR7L MT DME DM2AR7L MA Metabolism DM2AR7L RN Genetically based impairment in CYP2C8- and CYP2C9-dependent NSAID metabolism as a risk factor for gastrointestinal bleeding: is a combination of pharmacogenomics and metabolomics required to improve personalized medicine? Expert Opin Drug Metab Toxicol. 2009 Jun;5(6):607-20. DM2AR7L RU https://www.ncbi.nlm.nih.gov/pubmed/?term=19422321 DM2AR7L DI DM2AR7L DM2AR7L DN Meloxicam DM2AR7L MI DE5IED8 DM2AR7L MN Cytochrome P450 2C9 (CYP2C9) DM2AR7L MT DME DM2AR7L MA Metabolism DM2AR7L RN Summary of information on human CYP enzymes: human P450 metabolism data. Drug Metab Rev. 2002 Feb-May;34(1-2):83-448. DM2AR7L RU https://www.ncbi.nlm.nih.gov/pubmed/?term=11996015 DM2AR7L DI DM2AR7L DM2AR7L DN Meloxicam DM2AR7L MI DE4LYSA DM2AR7L MN Cytochrome P450 3A4 (CYP3A4) DM2AR7L MT DME DM2AR7L MA Metabolism DM2AR7L RN Activation of human cytochrome P-450 3A4-catalyzed meloxicam 5'-methylhydroxylation by quinidine and hydroquinidine in vitro. J Pharmacol Exp Ther. 1999 Jul;290(1):1-8. DM2AR7L RU https://www.ncbi.nlm.nih.gov/pubmed/?term=10381752 DM2AR7L DI DM2AR7L DM2AR7L DN Meloxicam DM2AR7L MI TTVKILB DM2AR7L MN Prostaglandin G/H synthase 2 (COX-2) DM2AR7L MT DTT DM2AR7L MA Inhibitor DM2AR7L RN Meloxicam: selective COX-2 inhibition in clinical practice. Semin Arthritis Rheum. 1997 Jun;26(6 Suppl 1):21-7. DM2AR7L RU https://pubmed.ncbi.nlm.nih.gov/9219316 DMOLNHF DI DMOLNHF DMOLNHF DN Melphalan DMOLNHF MI DE4ZHS1 DMOLNHF MN Glutathione S-transferase alpha-1 (GSTA1) DMOLNHF MT DME DMOLNHF MA Metabolism DMOLNHF RN Metabolism of melphalan by rat liver microsomal glutathione S-transferase. Chem Biol Interact. 2005 Apr 15;152(2-3):101-6. DMOLNHF RU https://www.ncbi.nlm.nih.gov/pubmed/?term=15840383 DMOLNHF DI DMOLNHF DMOLNHF DN Melphalan DMOLNHF MI TTUTN1I DMOLNHF MN Human Deoxyribonucleic acid (hDNA) DMOLNHF MT DTT DMOLNHF MA Modulator DMOLNHF RN Alkylation of DNA by melphalan in relation to immunoassay of melphalan-DNA adducts: characterization of mono-alkylated and cross-linked products fr... Chem Biol Interact. 1990;73(2-3):183-94. DMOLNHF RU https://www.ncbi.nlm.nih.gov/pubmed/2155711 DMOLNHF DI DMOLNHF DMOLNHF DN Melphalan DMOLNHF MI DTUGYRD DMOLNHF MN P-glycoprotein 1 (ABCB1) DMOLNHF MT DTP DMOLNHF MA Substrate DMOLNHF RN Multidrug resistance protein-mediated transport of chlorambucil and melphalan conjugated to glutathione. Br J Cancer. 1998;77(2):201-9. DMOLNHF RU http://www.ncbi.nlm.nih.gov/pubmed/9460989 DMWF5R4 DI DMWF5R4 DMWF5R4 DN Melphalan flufenamide DMWF5R4 MI TTUTN1I DMWF5R4 MN Human Deoxyribonucleic acid (hDNA) DMWF5R4 MT DTT DMWF5R4 MA Binder DMWF5R4 RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health Human Services. 2021 DMWF5R4 RU https://www.accessdata.fda.gov/drugsatfda_docs/label/2021/214383s000lbl.pdf DMD9WSC DI DMD9WSC DMD9WSC DN Memantine DMD9WSC MI TT9IK2Z DMD9WSC MN N-methyl-D-aspartate receptor (NMDAR) DMD9WSC MT DTT DMD9WSC MA Modulator DMD9WSC RN The NMDA receptor antagonist memantine as a symptomatological and neuroprotective treatment for Alzheimer's disease: preclinical evidence. Int J Geriatr Psychiatry. 2003 Sep;18(Suppl 1):S23-32. DMD9WSC RU https://pubmed.ncbi.nlm.nih.gov/12973747 DMD9WSC DI DMD9WSC DMD9WSC DN Memantine DMD9WSC MI DT9IDPW DMD9WSC MN Organic cation transporter 2 (SLC22A2) DMD9WSC MT DTP DMD9WSC MA Substrate DMD9WSC RN Human neurons express the polyspecific cation transporter hOCT2, which translocates monoamine neurotransmitters, amantadine, and memantine. Mol Pharmacol. 1998 Aug;54(2):342-52. DMD9WSC RU http://www.ncbi.nlm.nih.gov/pubmed/9687576 DMP9N85 DI DMP9N85 DMP9N85 DN Menadiol sodium diphosphate DMP9N85 MI DE3N2FM DMP9N85 MN NADPH-cytochrome P450 reductase (CPR) DMP9N85 MT DME DMP9N85 MA Metabolism DMP9N85 RN Creatinine sulfate/esculoside/hesperidin methyl chalcone/menadiol sodium phosphate/tranexamic acid actions. DMP9N85 RU https://www.ndrugs.com/?s=creatinine%20sulfate/esculoside/hesperidin%20methyl%20chalcone/menadiol%20sodium%20phosphate/tranexamic%20acid&t=actions#doctor_pharmacology DMP9N85 DI DMP9N85 DMP9N85 DN Menadiol sodium diphosphate DMP9N85 MI DEVRYQN DMP9N85 MN Vitamin K1 2,3-epoxide reductase 1 (VKOR) DMP9N85 MT DME DMP9N85 MA Metabolism DMP9N85 RN SMPDB database: Vitamin K Metabolism DMP9N85 RU http://smpdb.ca/view/SMP00464 DMSJDTY DI DMSJDTY DMSJDTY DN Menadione DMSJDTY MI TT3MOS2 DMSJDTY MN Aldehyde oxidase (AOX1) DMSJDTY MT DTT DMSJDTY MA Inhibitor DMSJDTY RN Inhibition by SKF-525A of the aldehyde oxidase-mediated metabolism of the experimental antitumour agent acridine carboxamide. Biochem Pharmacol. 1993 May 25;45(10):2159-62. DMSJDTY RU https://pubmed.ncbi.nlm.nih.gov/8512597 DMSJDTY DI DMSJDTY DMSJDTY DN Menadione DMSJDTY MI DTI7UX6 DMSJDTY MN Breast cancer resistance protein (ABCG2) DMSJDTY MT DTP DMSJDTY MA Substrate DMSJDTY RN The naphthoquinones, vitamin K3 and its structural analogue plumbagin, are substrates of the multidrug resistance linked ATP binding cassette drug transporter ABCG2. Mol Cancer Ther. 2007 Dec;6(12 Pt 1):3279-86. DMSJDTY RU http://www.ncbi.nlm.nih.gov/pubmed/18065489 DMSJDTY DI DMSJDTY DMSJDTY DN Menadione DMSJDTY MI DE6OQ3W DMSJDTY MN Cytochrome P450 1A1 (CYP1A1) DMSJDTY MT DME DMSJDTY MA Metabolism DMSJDTY RN Rat hepatic CYP1A1 and CYP1A2 induction by menadione. Toxicol Lett. 2005 Feb 15;155(2):253-8. DMSJDTY RU https://www.ncbi.nlm.nih.gov/pubmed/?term=15603920 DMSJDTY DI DMSJDTY DMSJDTY DN Menadione DMSJDTY MI DEJGDUW DMSJDTY MN Cytochrome P450 1A2 (CYP1A2) DMSJDTY MT DME DMSJDTY MA Metabolism DMSJDTY RN Rat hepatic CYP1A1 and CYP1A2 induction by menadione. Toxicol Lett. 2005 Feb 15;155(2):253-8. DMSJDTY RU https://www.ncbi.nlm.nih.gov/pubmed/?term=15603920 DMSJDTY DI DMSJDTY DMSJDTY DN Menadione DMSJDTY MI DEVDYN7 DMSJDTY MN Cytochrome P450 2E1 (CYP2E1) DMSJDTY MT DME DMSJDTY MA Metabolism DMSJDTY RN CYP2E1 overexpression alters hepatocyte death from menadione and fatty acids by activation of ERK1/2 signaling. Hepatology. 2004 Feb;39(2):444-55. DMSJDTY RU https://www.ncbi.nlm.nih.gov/pubmed/?term=14767997 DMSJDTY DI DMSJDTY DMSJDTY DN Menadione DMSJDTY MI DE6NIY9 DMSJDTY MN Methionine synthase reductase (MTRR) DMSJDTY MT DME DMSJDTY MA Metabolism DMSJDTY RN Differences in the efficiency of reductive activation of methionine synthase and exogenous electron acceptors between the common polymorphic variants of human methionine synthase reductase. Biochemistry. 2002 Nov 12;41(45):13378-85. DMSJDTY RU https://www.ncbi.nlm.nih.gov/pubmed/?term=12416982 DMSJDTY DI DMSJDTY DMSJDTY DN Menadione DMSJDTY MI DEOXTPZ DMSJDTY MN Methylenetetrahydrofolate reductase (MTHFR) DMSJDTY MT DME DMSJDTY MA Metabolism DMSJDTY RN Purification and properties of 5,10-methylenetetrahydrofolate reductase, an iron-sulfur flavoprotein from Clostridium formicoaceticum. J Biol Chem. 1984 Sep 10;259(17):10845-9. DMSJDTY RU https://www.ncbi.nlm.nih.gov/pubmed/?term=6381490 DMSJDTY DI DMSJDTY DMSJDTY DN Menadione DMSJDTY MI DE8RYV5 DMSJDTY MN NADPH:quinone reductase (CRYZ) DMSJDTY MT DME DMSJDTY MA Metabolism DMSJDTY RN Role of glutathione reductase during menadione-induced NADPH oxidation in isolated rat hepatocytes. Biochem Pharmacol. 1987 Nov 15;36(22):3879-84. DMSJDTY RU https://www.ncbi.nlm.nih.gov/pubmed/?term=3689427 DMSJDTY DI DMSJDTY DMSJDTY DN Menadione DMSJDTY MI DE9JFMC DMSJDTY MN NADPH-dependent carbonyl reductase 1 (CBR1) DMSJDTY MT DME DMSJDTY MA Metabolism DMSJDTY RN Polycyclic aromatic hydrocarbon quinones and glutathione thioethers as substrates and inhibitors of the human placental NADP-linked 15-hydroxyprostaglandin dehydrogenase. J Biol Chem. 1987 Sep 15;262(26):12448-51. DMSJDTY RU https://www.ncbi.nlm.nih.gov/pubmed/?term=3624267 DMSJDTY DI DMSJDTY DMSJDTY DN Menadione DMSJDTY MI DEIVKZ8 DMSJDTY MN NADPH-dependent carbonyl reductase 3 (CBR3) DMSJDTY MT DME DMSJDTY MA Metabolism DMSJDTY RN Different functions between human monomeric carbonyl reductase 3 and carbonyl reductase 1. Mol Cell Biochem. 2008 Aug;315(1-2):113-21. DMSJDTY RU https://www.ncbi.nlm.nih.gov/pubmed/?term=18493841 DMSJDTY DI DMSJDTY DMSJDTY DN Menadione DMSJDTY MI DEPG9C0 DMSJDTY MN Nitroreductase (NTR) DMSJDTY MT DME DMSJDTY MA Metabolism DMSJDTY RN Purification and characterization of wild-type and mutant "classical" nitroreductases of Salmonella typhimurium. L33R mutation greatly diminishes binding of FMN to the nitroreductase of S. typhimurium. J Biol Chem. 1998 Sep 11;273(37):23922-8. DMSJDTY RU https://pubmed.ncbi.nlm.nih.gov/9727006 DMSJDTY DI DMSJDTY DMSJDTY DN Menadione DMSJDTY MI DEJVDAT DMSJDTY MN Sepiapterin reductase (SPR) DMSJDTY MT DME DMSJDTY MA Metabolism DMSJDTY RN Sepiapterin reductase mediates chemical redox cycling in lung epithelial cells. J Biol Chem. 2013 Jun 28;288(26):19221-37. DMSJDTY RU https://www.ncbi.nlm.nih.gov/pubmed/?term=23640889 DMSJDTY DI DMSJDTY DMSJDTY DN Menadione DMSJDTY MI TTPFZJ1 DMSJDTY MN Vasopressin V1 receptor (V1R) DMSJDTY MT DTT DMSJDTY MA Agonist DMSJDTY RN Evidence in hyponatremia related to inappropriate secretion of ADH that V1 receptor stimulation contributes to the increase in renal uric acid clearance. J Am Soc Nephrol. 1996 May;7(5):805-10. DMSJDTY RU https://pubmed.ncbi.nlm.nih.gov/8738818 DM2SR1J DI DM2SR1J DM2SR1J DN Meningococcal groups A, C, Y and W-135 conjugate vaccine DM2SR1J MI TTY4IQ9 DM2SR1J MN Corynebacterium Mutated CRM197 (Cory mTOX) DM2SR1J MT DTT DM2SR1J MA Binder DM2SR1J RN Mullard A: 2010 FDA drug approvals. Nat Rev Drug Discov. 2011 Feb;10(2):82-5. DM2SR1J RU https://pubmed.ncbi.nlm.nih.gov/21283092 DM4CF18 DI DM4CF18 DM4CF18 DN Menotropins DM4CF18 MI TTZFDBT DM4CF18 MN Follicle-stimulating hormone receptor (FSHR) DM4CF18 MT DTT DM4CF18 MA Binder DM4CF18 RN The role of gonadotropins in ovulation induction. Am J Obstet Gynecol. 1995 Feb;172(2 Pt 2):759-65. DM4CF18 RU https://pubmed.ncbi.nlm.nih.gov/7872378 DMG2KW7 DI DMG2KW7 DMG2KW7 DN Menthol DMG2KW7 MI TTXDKTO DMG2KW7 MN Long transient receptor potential channel 8 (TRPM8) DMG2KW7 MT DTT DMG2KW7 MA Activator DMG2KW7 RN TRPV1-mediated itch in seasonal allergic rhinitis. Allergy. 2009 May;64(5):807-10. DMG2KW7 RU https://pubmed.ncbi.nlm.nih.gov/19220220 DMG2KW7 DI DMG2KW7 DMG2KW7 DN Menthol DMG2KW7 MI TTELV3W DMG2KW7 MN Transformation-sensitive protein p120 (TRPA1) DMG2KW7 MT DTT DMG2KW7 MA Activator DMG2KW7 RN TRPV1-mediated itch in seasonal allergic rhinitis. Allergy. 2009 May;64(5):807-10. DMG2KW7 RU https://pubmed.ncbi.nlm.nih.gov/19220220 DM8YU2F DI DM8YU2F DM8YU2F DN Mepenzolate DM8YU2F MI TTH18TF DM8YU2F MN Muscarinic acetylcholine receptor M5 (CHRM5) DM8YU2F MT DTT DM8YU2F MA Antagonist DM8YU2F RN Isolation of cholinergic active ingredients in aqueous extracts of Mareya micrantha using the longitudinal muscle of isolated guinea-pig ileum as a pharmacological activity marker. J Ethnopharmacol. 1995 Mar;45(3):215-22. DM8YU2F RU https://pubmed.ncbi.nlm.nih.gov/7623487 DMX4GND DI DMX4GND DMX4GND DN Meperidine DMX4GND MI TTQ8AFT DMX4GND MN Adrenergic receptor Alpha-2 (ADRA2) DMX4GND MT DTT DMX4GND MA Agonist DMX4GND RN Meperidine, remifentanil and tramadol but not sufentanil interact with alpha(2)-adrenoceptors in alpha(2A)-, alpha(2B)- and alpha(2C)-adrenoceptor ... Eur J Pharmacol. 2008 Mar 17;582(1-3):70-7. DMX4GND RU https://pubmed.ncbi.nlm.nih.gov/18234187 DMX4GND DI DMX4GND DMX4GND DN Meperidine DMX4GND MI DEPKLMQ DMX4GND MN Cytochrome P450 2B6 (CYP2B6) DMX4GND MT DME DMX4GND MA Metabolism DMX4GND RN Insights into CYP2B6-mediated drug-drug interactions. Acta Pharm Sin B. 2016 Sep;6(5):413-425. DMX4GND RU https://www.ncbi.nlm.nih.gov/pubmed/?term=27709010 DMX4GND DI DMX4GND DMX4GND DN Meperidine DMX4GND MI DECB0K3 DMX4GND MN Cytochrome P450 2D6 (CYP2D6) DMX4GND MT DME DMX4GND MA Metabolism DMX4GND RN CYP2B6, CYP3A4, and CYP2C19 are responsible for the in vitro N-demethylation of meperidine in human liver microsomes. Drug Metab Dispos. 2004 Sep;32(9):930-6. DMX4GND RU https://www.ncbi.nlm.nih.gov/pubmed/?term=15319333 DMX4GND DI DMX4GND DMX4GND DN Meperidine DMX4GND MI DE4LYSA DMX4GND MN Cytochrome P450 3A4 (CYP3A4) DMX4GND MT DME DMX4GND MA Metabolism DMX4GND RN Is meperidine the drug that just won't die? J Pediatr Pharmacol Ther. 2011 Jul;16(3):167-9. DMX4GND RU https://www.ncbi.nlm.nih.gov/pubmed/?term=22479158 DMX4GND DI DMX4GND DMX4GND DN Meperidine DMX4GND MI DEGTFWK DMX4GND MN Mephenytoin 4-hydroxylase (CYP2C19) DMX4GND MT DME DMX4GND MA Metabolism DMX4GND RN Impact of cytochrome P450 variation on meperidine N-demethylation to the neurotoxic metabolite normeperidine. Xenobiotica. 2020 Feb;50(2):209-222. DMX4GND RU https://www.ncbi.nlm.nih.gov/pubmed/?term=30902024 DMX4GND DI DMX4GND DMX4GND DN Meperidine DMX4GND MI DTUGYRD DMX4GND MN P-glycoprotein 1 (ABCB1) DMX4GND MT DTP DMX4GND MA Substrate DMX4GND RN Opioids and efflux transporters. Part 3: P-glycoprotein substrate activity of 3-hydroxyl addition to meperidine analogs. Bioorg Med Chem Lett. 2008 Jun 15;18(12):3638-40. DMX4GND RU http://www.ncbi.nlm.nih.gov/pubmed/18499452 DMFJH5Q DI DMFJH5Q DMFJH5Q DN Mephentermine DMFJH5Q MI TTEX248 DMFJH5Q MN Dopamine D2 receptor (D2R) DMFJH5Q MT DTT DMFJH5Q MA Agonist DMFJH5Q RN Present state of alpha- and beta-adrenergic drugs I. The adrenergic receptor. Am Heart J. 1976 Nov;92(5):661-4. DMFJH5Q RU https://pubmed.ncbi.nlm.nih.gov/10722 DM5UGDK DI DM5UGDK DM5UGDK DN Mephenytoin DM5UGDK MI DEJGDUW DM5UGDK MN Cytochrome P450 1A2 (CYP1A2) DM5UGDK MT DME DM5UGDK MA Metabolism DM5UGDK RN Comparison of (S)-mephenytoin and proguanil oxidation in vitro: contribution of several CYP isoforms. Br J Clin Pharmacol. 1999 Aug;48(2):158-67. DM5UGDK RU https://www.ncbi.nlm.nih.gov/pubmed/?term=10417492 DM5UGDK DI DM5UGDK DM5UGDK DN Mephenytoin DM5UGDK MI DEPKLMQ DM5UGDK MN Cytochrome P450 2B6 (CYP2B6) DM5UGDK MT DME DM5UGDK MA Metabolism DM5UGDK RN Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. DM5UGDK RU https://www.ncbi.nlm.nih.gov/pubmed/?term=19515014 DM5UGDK DI DM5UGDK DM5UGDK DN Mephenytoin DM5UGDK MI DEZMWRE DM5UGDK MN Cytochrome P450 2C18 (CYP2C18) DM5UGDK MT DME DM5UGDK MA Metabolism DM5UGDK RN Cytochrome P450 metabolic dealkylation of nine N-nitrosodialkylamines by human liver microsomes. Carcinogenesis. 1996 Sep;17(9):2029-34. DM5UGDK RU https://www.ncbi.nlm.nih.gov/pubmed/?term=8824531 DM5UGDK DI DM5UGDK DM5UGDK DN Mephenytoin DM5UGDK MI DES5XRU DM5UGDK MN Cytochrome P450 2C8 (CYP2C8) DM5UGDK MT DME DM5UGDK MA Metabolism DM5UGDK RN Evidence that CYP2C19 is the major (S)-mephenytoin 4'-hydroxylase in humans. Biochemistry. 1994 Feb 22;33(7):1743-52. DM5UGDK RU https://www.ncbi.nlm.nih.gov/pubmed/?term=8110777 DM5UGDK DI DM5UGDK DM5UGDK DN Mephenytoin DM5UGDK MI DE5IED8 DM5UGDK MN Cytochrome P450 2C9 (CYP2C9) DM5UGDK MT DME DM5UGDK MA Metabolism DM5UGDK RN Cytochrome P450 metabolic dealkylation of nine N-nitrosodialkylamines by human liver microsomes. Carcinogenesis. 1996 Sep;17(9):2029-34. DM5UGDK RU https://www.ncbi.nlm.nih.gov/pubmed/?term=8824531 DM5UGDK DI DM5UGDK DM5UGDK DN Mephenytoin DM5UGDK MI DECB0K3 DM5UGDK MN Cytochrome P450 2D6 (CYP2D6) DM5UGDK MT DME DM5UGDK MA Metabolism DM5UGDK RN Ethnic differences in genetic polymorphisms of CYP2D6, CYP2C19, CYP3As and MDR1/ABCB1. Drug Metab Pharmacokinet. 2004 Apr;19(2):83-95. DM5UGDK RU https://www.ncbi.nlm.nih.gov/pubmed/?term=15499174 DM5UGDK DI DM5UGDK DM5UGDK DN Mephenytoin DM5UGDK MI DE4LYSA DM5UGDK MN Cytochrome P450 3A4 (CYP3A4) DM5UGDK MT DME DM5UGDK MA Metabolism DM5UGDK RN Species differences in stereoselective metabolism of mephenytoin by cytochrome P450 (CYP2C and CYP3A). J Pharmacol Exp Ther. 1993 Jan;264(1):89-94. DM5UGDK RU https://www.ncbi.nlm.nih.gov/pubmed/?term=8423554 DM5UGDK DI DM5UGDK DM5UGDK DN Mephenytoin DM5UGDK MI DEIBDNY DM5UGDK MN Cytochrome P450 3A5 (CYP3A5) DM5UGDK MT DME DM5UGDK MA Metabolism DM5UGDK RN Species differences in stereoselective metabolism of mephenytoin by cytochrome P450 (CYP2C and CYP3A). J Pharmacol Exp Ther. 1993 Jan;264(1):89-94. DM5UGDK RU https://www.ncbi.nlm.nih.gov/pubmed/?term=8423554 DM5UGDK DI DM5UGDK DM5UGDK DN Mephenytoin DM5UGDK MI DEGTFWK DM5UGDK MN Mephenytoin 4-hydroxylase (CYP2C19) DM5UGDK MT DME DM5UGDK MA Metabolism DM5UGDK RN Cytochromes P450 mediating the N-demethylation of amitriptyline. Br J Clin Pharmacol. 1997 Feb;43(2):137-44. DM5UGDK RU https://www.ncbi.nlm.nih.gov/pubmed/?term=9131945 DM5UGDK DI DM5UGDK DM5UGDK DN Mephenytoin DM5UGDK MI TTZOVE0 DM5UGDK MN Voltage-gated sodium channel alpha Nav1.5 (SCN5A) DM5UGDK MT DTT DM5UGDK MA Blocker DM5UGDK RN Lacosamide: a new approach to target voltage-gated sodium currents in epileptic disorders. CNS Drugs. 2009;23(7):555-68. DM5UGDK RU https://pubmed.ncbi.nlm.nih.gov/19552484 DMUDWP9 DI DMUDWP9 DMUDWP9 DN Mepindolol DMUDWP9 MI TTMXGCW DMUDWP9 MN Adrenergic receptor beta-3 (ADRB3) DMUDWP9 MT DTT DMUDWP9 MA Modulator DMUDWP9 RN Pharmacological studies on the intrinsic sympathomimetic activity of the beta-adrenoceptor antagonist mepindolol. Arzneimittelforschung. 1986 May;36(5):811-3. DMUDWP9 RU https://pubmed.ncbi.nlm.nih.gov/2873820 DMUDWP9 DI DMUDWP9 DMUDWP9 DN Mepindolol DMUDWP9 MI DECB0K3 DMUDWP9 MN Cytochrome P450 2D6 (CYP2D6) DMUDWP9 MT DME DMUDWP9 MA Metabolism DMUDWP9 RN Application of substrate depletion assay to evaluation of CYP isoforms responsible for stereoselective metabolism of carvedilol. Drug Metab Pharmacokinet. 2016 Dec;31(6):425-432. DMUDWP9 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=27836712 DMH2NMY DI DMH2NMY DMH2NMY DN Mepivacaine DMH2NMY MI TTRK8B9 DMH2NMY MN Sodium channel unspecific (NaC) DMH2NMY MT DTT DMH2NMY MA Blocker DMH2NMY RN Block of neuronal tetrodotoxin-resistant Na+ currents by stereoisomers of piperidine local anesthetics. Anesth Analg. 2000 Dec;91(6):1499-505. DMH2NMY RU https://pubmed.ncbi.nlm.nih.gov/11094008 DMW2GEJ DI DMW2GEJ DMW2GEJ DN Mepolizumab DMW2GEJ MI TTPREZD DMW2GEJ MN Interleukin-5 (IL5) DMW2GEJ MT DTT DMW2GEJ MA Modulator DMW2GEJ RN Mepolizumab: 240563, anti-IL-5 monoclonal antibody - GlaxoSmithKline, anti-interleukin-5 monoclonal antibody - GlaxoSmithKline, SB 240563. Drugs R D. 2008;9(2):125-30. DMW2GEJ RU https://www.ncbi.nlm.nih.gov/pubmed/18298130 DMTL9IP DI DMTL9IP DMTL9IP DN Meprednisone DMTL9IP MI DE4LYSA DMTL9IP MN Cytochrome P450 3A4 (CYP3A4) DMTL9IP MT DME DMTL9IP MA Metabolism DMTL9IP RN Regulation of drug-metabolizing cytochrome P450 enzymes by glucocorticoids. Drug Metab Rev. 2010 Nov;42(4):621-35. DMTL9IP RU https://www.ncbi.nlm.nih.gov/pubmed/?term=20482443 DMTL9IP DI DMTL9IP DMTL9IP DN Meprednisone DMTL9IP MI TTYRL6O DMTL9IP MN Glucocorticoid receptor (NR3C1) DMTL9IP MT DTT DMTL9IP MA Modulator DMTL9IP RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. DMTL9IP RU https://www.fda.gov/ DMHM93Y DI DMHM93Y DMHM93Y DN Meprobamate DMHM93Y MI DEVDYN7 DMHM93Y MN Cytochrome P450 2E1 (CYP2E1) DMHM93Y MT DME DMHM93Y MA Metabolism DMHM93Y RN Mechanisms of circadian rhythmicity of carbon tetrachloride hepatotoxicity. J Pharmacol Exp Ther. 2002 Jan;300(1):273-81. DMHM93Y RU https://www.ncbi.nlm.nih.gov/pubmed/?term=11752126 DMHM93Y DI DMHM93Y DMHM93Y DN Meprobamate DMHM93Y MI TT1MPAY DMHM93Y MN GABA(A) receptor alpha-1 (GABRA1) DMHM93Y MT DTT DMHM93Y MA Antagonist DMHM93Y RN DrugBank: a knowledgebase for drugs, drug actions and drug targets. Nucleic Acids Res. 2008 Jan;36(Database issue):D901-6. DMHM93Y RU https://pubmed.ncbi.nlm.nih.gov/18048412 DMHM93Y DI DMHM93Y DMHM93Y DN Meprobamate DMHM93Y MI DEGTFWK DMHM93Y MN Mephenytoin 4-hydroxylase (CYP2C19) DMHM93Y MT DME DMHM93Y MA Metabolism DMHM93Y RN Association between blood carisoprodol:meprobamate concentration ratios and CYP2C19 genotype in carisoprodol-drugged drivers: decreased metabolic capacity in heterozygous CYP2C19*1/CYP2C19*2 subjects? Pharmacogenetics. 2003 Jul;13(7):383-8. DMHM93Y RU https://www.ncbi.nlm.nih.gov/pubmed/?term=12835613 DMHM93Y DI DMHM93Y DMHM93Y DN Meprobamate DMHM93Y MI TT9SL3Q DMHM93Y MN Polypeptide deformylase (PDF) DMHM93Y MT DTT DMHM93Y MA Inhibitor DMHM93Y RN The fight against drug-resistant malaria: novel plasmodial targets and antimalarial drugs. Curr Med Chem. 2008;15(2):161-71. DMHM93Y RU https://pubmed.ncbi.nlm.nih.gov/18220771 DMHM93Y DI DMHM93Y DMHM93Y DN Meprobamate DMHM93Y MI TTBZ7OD DMHM93Y MN Protein kinase C epsilon (PRKCE) DMHM93Y MT DTT DMHM93Y MA Stimulator DMHM93Y RN Protein kinase C, an elusive therapeutic target . Nat Rev Drug Discov. 2012 December; 11(12): 937-957. DMHM93Y RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3760692/ DMHM93Y DI DMHM93Y DMHM93Y DN Meprobamate DMHM93Y MI DEYGVN4 DMHM93Y MN UDP-glucuronosyltransferase 1A1 (UGT1A1) DMHM93Y MT DME DMHM93Y MA Metabolism DMHM93Y RN Solid-phase synthesis of drug glucuronides by immobilized glucuronosyltransferase. J Med Chem. 1976 May;19(5):679-83. DMHM93Y RU https://www.ncbi.nlm.nih.gov/pubmed/?term=818382 DMPSB8F DI DMPSB8F DMPSB8F DN MEPTAZINOL DMPSB8F MI TTEB0GD DMPSB8F MN Cholinesterase (BCHE) DMPSB8F MT DTT DMPSB8F MA Inhibitor DMPSB8F RN Bis-(-)-nor-meptazinols as novel nanomolar cholinesterase inhibitors with high inhibitory potency on amyloid-beta aggregation. J Med Chem. 2008 Apr 10;51(7):2027-36. DMPSB8F RU https://pubmed.ncbi.nlm.nih.gov/18333606 DMB4SFH DI DMB4SFH DMB4SFH DN Mepyramine DMB4SFH MI TTTIBOJ DMB4SFH MN Histamine H1 receptor (H1R) DMB4SFH MT DTT DMB4SFH MA Antagonist DMB4SFH RN Antinociception induced by central administration of histamine in the formalin test in rats. Indian J Physiol Pharmacol. 2008 Jul-Sep;52(3):249-54. DMB4SFH RU https://pubmed.ncbi.nlm.nih.gov/19552055 DMB4SFH DI DMB4SFH DMB4SFH DN Mepyramine DMB4SFH MI DT3HUVD DMB4SFH MN Organic cation/carnitine transporter 2 (SLC22A5) DMB4SFH MT DTP DMB4SFH MA Substrate DMB4SFH RN Genetic deficiency of carnitine/organic cation transporter 2 (slc22a5) is associated with altered tissue distribution of its substrate pyrilamine in mice. Biopharm Drug Dispos. 2009 Dec;30(9):495-507. DMB4SFH RU http://www.ncbi.nlm.nih.gov/pubmed/19821448 DM7F5OW DI DM7F5OW DM7F5OW DN Mepyramine maleate DM7F5OW MI TTTIBOJ DM7F5OW MN Histamine H1 receptor (H1R) DM7F5OW MT DTT DM7F5OW MA Antagonist DM7F5OW RN Antinociception induced by central administration of histamine in the formalin test in rats. Indian J Physiol Pharmacol. 2008 Jul-Sep;52(3):249-54. DM7F5OW RU https://pubmed.ncbi.nlm.nih.gov/19552055 DMAFBCY DI DMAFBCY DMAFBCY DN Mequitazine DMAFBCY MI DECB0K3 DMAFBCY MN Cytochrome P450 2D6 (CYP2D6) DMAFBCY MT DME DMAFBCY MA Metabolism DMAFBCY RN Oxidation of histamine H1 antagonist mequitazine is catalyzed by cytochrome P450 2D6 in human liver microsomes. J Pharmacol Exp Ther. 1998 Feb;284(2):437-42. DMAFBCY RU https://www.ncbi.nlm.nih.gov/pubmed/?term=9454781 DMAFBCY DI DMAFBCY DMAFBCY DN Mequitazine DMAFBCY MI TTTIBOJ DMAFBCY MN Histamine H1 receptor (H1R) DMAFBCY MT DTT DMAFBCY MA Antagonist DMAFBCY RN Efficiency of mequitazine in the treatment of allergic rhinitis and chronic urticaria in children. A bibliographic systematic review. Rev Alerg Mex. 2008 Jan-Feb;55(1):3-9. DMAFBCY RU https://pubmed.ncbi.nlm.nih.gov/18697448 DMAFBCY DI DMAFBCY DMAFBCY DN Mequitazine DMAFBCY MI DTUGYRD DMAFBCY MN P-glycoprotein 1 (ABCB1) DMAFBCY MT DTP DMAFBCY MA Substrate DMAFBCY RN Passive permeability and P-glycoprotein-mediated efflux differentiate central nervous system (CNS) and non-CNS marketed drugs. J Pharmacol Exp Ther. 2002 Dec;303(3):1029-37. DMAFBCY RU http://www.ncbi.nlm.nih.gov/pubmed/12438524 DMTM2IK DI DMTM2IK DMTM2IK DN Mercaptopurine DMTM2IK MI TTZFTY4 DMTM2IK MN Amidophosphoribosyltransferase (PPAT) DMTM2IK MT DTT DMTM2IK MA Breaker DMTM2IK RN 6-mercaptopurine (6-MP) induces p53-mediated apoptosis of neural progenitor cells in the developing fetal rodent brain. Neurotoxicol Teratol. 2009 Jul-Aug;31(4):198-202. DMTM2IK RU https://pubmed.ncbi.nlm.nih.gov/19281843 DMTM2IK DI DMTM2IK DMTM2IK DN Mercaptopurine DMTM2IK MI DTI7UX6 DMTM2IK MN Breast cancer resistance protein (ABCG2) DMTM2IK MT DTP DMTM2IK MA Substrate DMTM2IK RN ABC transporters and their role in nucleoside and nucleotide drug resistance. Biochem Pharmacol. 2012 Apr 15;83(8):1073-83. DMTM2IK RU https://doi.org/10.1016/j.bcp.2011.12.042 DMTM2IK DI DMTM2IK DMTM2IK DN Mercaptopurine DMTM2IK MI DT4YL5R DMTM2IK MN Concentrative Na(+)-nucleoside cotransporter 3 (SLC28A3) DMTM2IK MT DTP DMTM2IK MA Substrate DMTM2IK RN Involvement of the concentrative nucleoside transporter 3 and equilibrative nucleoside transporter 2 in the resistance of T-lymphoblastic cell lines to thiopurines. Biochem Biophys Res Commun. 2006 Apr 28;343(1):208-15. DMTM2IK RU http://www.ncbi.nlm.nih.gov/pubmed/16530731 DMTM2IK DI DMTM2IK DMTM2IK DN Mercaptopurine DMTM2IK MI DT82KPY DMTM2IK MN Concentrative nucleoside transporter 2 (SLC28A2) DMTM2IK MT DTP DMTM2IK MA Substrate DMTM2IK RN PharmGKB: A worldwide resource for pharmacogenomic information. Wiley Interdiscip Rev Syst Biol Med. 2018 Jul;10(4):e1417. (ID: PA2040) DMTM2IK RU https://www.pharmgkb.org/pathway/PA2040 DMTM2IK DI DMTM2IK DMTM2IK DN Mercaptopurine DMTM2IK MI DE6OQ3W DMTM2IK MN Cytochrome P450 1A1 (CYP1A1) DMTM2IK MT DME DMTM2IK MA Metabolism DMTM2IK RN Pharmacogenomics in drug-metabolizing enzymes catalyzing anticancer drugs for personalized cancer chemotherapy. Curr Drug Metab. 2007 Aug;8(6):554-62. DMTM2IK RU https://www.ncbi.nlm.nih.gov/pubmed/?term=17691917 DMTM2IK DI DMTM2IK DMTM2IK DN Mercaptopurine DMTM2IK MI DTGBPR5 DMTM2IK MN Equilibrative nucleobase transporter 1 (SLC43A3) DMTM2IK MT DTP DMTM2IK MA Substrate DMTM2IK RN Characterization of 6-Mercaptopurine Transport by the SLC43A3-Encoded Nucleobase Transporter. Mol Pharmacol. 2019 Jun;95(6):584-596. DMTM2IK RU http://www.ncbi.nlm.nih.gov/pubmed/30910793 DMTM2IK DI DMTM2IK DMTM2IK DN Mercaptopurine DMTM2IK MI DTXD1TQ DMTM2IK MN Equilibrative nucleoside transporter 1 (SLC29A1) DMTM2IK MT DTP DMTM2IK MA Substrate DMTM2IK RN PharmGKB: A worldwide resource for pharmacogenomic information. Wiley Interdiscip Rev Syst Biol Med. 2018 Jul;10(4):e1417. (ID: PA2040) DMTM2IK RU https://www.pharmgkb.org/pathway/PA2040 DMTM2IK DI DMTM2IK DMTM2IK DN Mercaptopurine DMTM2IK MI DTW78DQ DMTM2IK MN Equilibrative nucleoside transporter 2 (SLC29A2) DMTM2IK MT DTP DMTM2IK MA Substrate DMTM2IK RN PharmGKB: A worldwide resource for pharmacogenomic information. Wiley Interdiscip Rev Syst Biol Med. 2018 Jul;10(4):e1417. (ID: PA2040) DMTM2IK RU https://www.pharmgkb.org/pathway/PA2040 DMTM2IK DI DMTM2IK DMTM2IK DN Mercaptopurine DMTM2IK MI TTL7C8Q DMTM2IK MN Inosine-5'-monophosphate dehydrogenase 1 (IMPDH1) DMTM2IK MT DTT DMTM2IK MA Inhibitor DMTM2IK RN Clinical pharmacology and pharmacogenetics of thiopurines. Eur J Clin Pharmacol. 2008 Aug;64(8):753-67. DMTM2IK RU https://pubmed.ncbi.nlm.nih.gov/18506437 DMTM2IK DI DMTM2IK DMTM2IK DN Mercaptopurine DMTM2IK MI DTCSGPB DMTM2IK MN Multidrug resistance-associated protein 4 (ABCC4) DMTM2IK MT DTP DMTM2IK MA Substrate DMTM2IK RN Polymorphisms in multidrug resistance-associated protein gene 4 is associated with outcome in childhood acute lymphoblastic leukemia. Blood. 2009 Aug 13;114(7):1383-6. DMTM2IK RU http://www.ncbi.nlm.nih.gov/pubmed/19515727 DMTM2IK DI DMTM2IK DMTM2IK DN Mercaptopurine DMTM2IK MI DTYVM24 DMTM2IK MN Multidrug resistance-associated protein 5 (ABCC5) DMTM2IK MT DTP DMTM2IK MA Substrate DMTM2IK RN Overexpression of MRP4 (ABCC4) and MRP5 (ABCC5) confer resistance to the nucleoside analogs cytarabine and troxacitabine, but not gemcitabine. Springerplus. 2014 Dec 13;3:732. DMTM2IK RU http://www.ncbi.nlm.nih.gov/pubmed/25674464 DMTM2IK DI DMTM2IK DMTM2IK DN Mercaptopurine DMTM2IK MI DTVP67E DMTM2IK MN Organic anion transporter 3 (SLC22A8) DMTM2IK MT DTP DMTM2IK MA Substrate DMTM2IK RN Organic anion transporter 3 is involved in the brain-to-blood efflux transport of thiopurine nucleobase analogs. J Neurochem. 2004 Aug;90(4):931-41. DMTM2IK RU http://www.ncbi.nlm.nih.gov/pubmed/15287899 DMTM2IK DI DMTM2IK DMTM2IK DN Mercaptopurine DMTM2IK MI DEFQ8VO DMTM2IK MN Thiopurine methyltransferase (TPMT) DMTM2IK MT DME DMTM2IK MA Metabolism DMTM2IK RN The degree of myelosuppression during maintenance therapy of adolescents with B-lineage intermediate risk acute lymphoblastic leukemia predicts risk of relapse. Leukemia. 2010 Apr;24(4):715-20. DMTM2IK RU https://www.ncbi.nlm.nih.gov/pubmed/?term=20130603 DMTM2IK DI DMTM2IK DMTM2IK DN Mercaptopurine DMTM2IK MI DEYGVN4 DMTM2IK MN UDP-glucuronosyltransferase 1A1 (UGT1A1) DMTM2IK MT DME DMTM2IK MA Metabolism DMTM2IK RN Pharmacogenomics in drug-metabolizing enzymes catalyzing anticancer drugs for personalized cancer chemotherapy. Curr Drug Metab. 2007 Aug;8(6):554-62. DMTM2IK RU https://www.ncbi.nlm.nih.gov/pubmed/?term=17691917 DM0HS92 DI DM0HS92 DM0HS92 DN Merimepodib DM0HS92 MI TTGKNB4 DM0HS92 MN Epidermal growth factor receptor (EGFR) DM0HS92 MT DTT DM0HS92 MA Inhibitor DM0HS92 RN Clinical pipeline report, company report or official report of GlaxoSmithKline (2009). DM0HS92 RU http://www.gsk.com/investors/product_pipeline/docs/gsk-pipeline-feb09.pdf DM0HS92 DI DM0HS92 DM0HS92 DN Merimepodib DM0HS92 MI TT6EO5L DM0HS92 MN Erbb2 tyrosine kinase receptor (HER2) DM0HS92 MT DTT DM0HS92 MA Inhibitor DM0HS92 RN Clinical pipeline report, company report or official report of GlaxoSmithKline (2009). DM0HS92 RU http://www.gsk.com/investors/product_pipeline/docs/gsk-pipeline-feb09.pdf DM0HS92 DI DM0HS92 DM0HS92 DN Merimepodib DM0HS92 MI TTL7C8Q DM0HS92 MN Inosine-5'-monophosphate dehydrogenase 1 (IMPDH1) DM0HS92 MT DTT DM0HS92 MA Inhibitor DM0HS92 RN VX-497: a novel, selective IMPDH inhibitor and immunosuppressive agent. J Pharm Sci. 2001 May;90(5):625-37. DM0HS92 RU https://pubmed.ncbi.nlm.nih.gov/11288107 DM62UHC DI DM62UHC DM62UHC DN Meropenem DM62UHC MI TTJP4SM DM62UHC MN Bacterial Penicillin binding protein (Bact PBP) DM62UHC MT DTT DM62UHC MA Modulator DM62UHC RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. DM62UHC RU https://www.fda.gov/ DM62UHC DI DM62UHC DM62UHC DN Meropenem DM62UHC MI DEC3G7M DM62UHC MN Beta-lactamase (blaB) DM62UHC MT DME DM62UHC MA Metabolism DM62UHC RN FRI-4 carbapenemase-producing Enterobacter cloacae complex isolated in Tokyo, Japan. J Antimicrob Chemother. 2018 Nov 1;73(11):2969-2972. DM62UHC RU https://pubmed.ncbi.nlm.nih.gov/30060114 DM62UHC DI DM62UHC DM62UHC DN Meropenem DM62UHC MI DENJ2SQ DM62UHC MN Beta-lactamase (blaB) DM62UHC MT DME DM62UHC MA Metabolism DM62UHC RN Prevalence of antimicrobial resistance genes in Bacteroides spp. and Prevotella spp. Dutch clinical isolates. Clin Microbiol Infect. 2019 Sep;25(9):1156.e9-1156.e13. DM62UHC RU https://pubmed.ncbi.nlm.nih.gov/30802650 DM62UHC DI DM62UHC DM62UHC DN Meropenem DM62UHC MI DEBKS91 DM62UHC MN Beta-lactamase (blaB) DM62UHC MT DME DM62UHC MA Metabolism DM62UHC RN A high mortality rate associated with multidrug-resistant Acinetobacter baumannii ST79 and ST25 carrying OXA-23 in a Brazilian intensive care unit. PLoS One. 2018 Dec 28;13(12):e0209367. DM62UHC RU https://pubmed.ncbi.nlm.nih.gov/30592758 DM62UHC DI DM62UHC DM62UHC DN Meropenem DM62UHC MI DECWSA9 DM62UHC MN Beta-lactamase (blaB) DM62UHC MT DME DM62UHC MA Metabolism DM62UHC RN Molecular investigation of extended-spectrum beta-lactamase genes and potential drug resistance in clinical isolates of Morganella morganii. Ann Saudi Med. 2016 May-Jun;36(3):223-8. DM62UHC RU https://pubmed.ncbi.nlm.nih.gov/27236395 DM62UHC DI DM62UHC DM62UHC DN Meropenem DM62UHC MI DEB90AL DM62UHC MN Carbapenemase (cphA) DM62UHC MT DME DM62UHC MA Metabolism DM62UHC RN A carbapenem-resistant clinical isolate of Aeromonas hydrophila in Japan harbouring an acquired gene encoding GES-24 beta-lactamase. J Med Microbiol. 2018 Nov;67(11):1535-1537. DM62UHC RU https://pubmed.ncbi.nlm.nih.gov/30289383 DM62UHC DI DM62UHC DM62UHC DN Meropenem DM62UHC MI DEBGCYQ DM62UHC MN New delhi metallo-beta-lactamase NDM-1 (blaNDM) DM62UHC MT DME DM62UHC MA Metabolism DM62UHC RN Genomic characterization of an extensively-drug resistance Salmonella enterica serotype Indiana strain harboring bla NDM-1 gene isolated from a chicken carcass in China. Microbiol Res. 2017 Nov;204:48-54. DM62UHC RU https://pubmed.ncbi.nlm.nih.gov/28870291 DM62UHC DI DM62UHC DM62UHC DN Meropenem DM62UHC MI DTQ23VB DM62UHC MN Organic anion transporter 1 (SLC22A6) DM62UHC MT DTP DM62UHC MA Substrate DM62UHC RN Characterization of CS-023 (RO4908463), a novel parenteral carbapenem antibiotic, and meropenem as substrates of human renal transporters. Drug Metab Pharmacokinet. 2007 Feb 25;22(1):41-7. DM62UHC RU http://www.ncbi.nlm.nih.gov/pubmed/17329910 DMOVAIX DI DMOVAIX DMOVAIX DN Meropenem + vaborbactam DMOVAIX MI TTHI19T DMOVAIX MN Staphylococcus Beta-lactamase (Stap-coc blaZ) DMOVAIX MT DTT DMOVAIX MA Inhibitor DMOVAIX RN 2017 FDA drug approvals.Nat Rev Drug Discov. 2018 Feb;17(2):81-85. DMOVAIX RU https://pubmed.ncbi.nlm.nih.gov/29348678 DMOL5IU DI DMOL5IU DMOL5IU DN Mesalazine DMOL5IU MI DTFI42L DMOL5IU MN Multidrug resistance-associated protein 2 (ABCC2) DMOL5IU MT DTP DMOL5IU MA Substrate DMOL5IU RN Transport studies with 5-aminosalicylate. Eur J Clin Pharmacol. 2006 Oct;62(10):871-5. DMOL5IU RU http://www.ncbi.nlm.nih.gov/pubmed/16944117 DMOL5IU DI DMOL5IU DMOL5IU DN Mesalazine DMOL5IU MI DT3D8F0 DMOL5IU MN Organic anion transporting polypeptide 1B1 (SLCO1B1) DMOL5IU MT DTP DMOL5IU MA Substrate DMOL5IU RN Role of organic anion-transporting polypeptides for cellular mesalazine (5-aminosalicylic acid) uptake. Drug Metab Dispos. 2011 Jun;39(6):1097-102. DMOL5IU RU http://www.ncbi.nlm.nih.gov/pubmed/21430235 DMOL5IU DI DMOL5IU DMOL5IU DN Mesalazine DMOL5IU MI DT9C1TS DMOL5IU MN Organic anion transporting polypeptide 1B3 (SLCO1B3) DMOL5IU MT DTP DMOL5IU MA Substrate DMOL5IU RN Role of organic anion-transporting polypeptides for cellular mesalazine (5-aminosalicylic acid) uptake. Drug Metab Dispos. 2011 Jun;39(6):1097-102. DMOL5IU RU http://www.ncbi.nlm.nih.gov/pubmed/21430235 DMOL5IU DI DMOL5IU DMOL5IU DN Mesalazine DMOL5IU MI DTPFTEQ DMOL5IU MN Organic anion transporting polypeptide 2B1 (SLCO2B1) DMOL5IU MT DTP DMOL5IU MA Substrate DMOL5IU RN Role of organic anion-transporting polypeptides for cellular mesalazine (5-aminosalicylic acid) uptake. Drug Metab Dispos. 2011 Jun;39(6):1097-102. DMOL5IU RU http://www.ncbi.nlm.nih.gov/pubmed/21430235 DMOL5IU DI DMOL5IU DMOL5IU DN Mesalazine DMOL5IU MI TT8NGED DMOL5IU MN Prostaglandin G/H synthase 1 (COX-1) DMOL5IU MT DTT DMOL5IU MA Inhibitor DMOL5IU RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMOL5IU RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMOL5IU DI DMOL5IU DMOL5IU DN Mesalazine DMOL5IU MI DEZV4AP DMOL5IU MN RNA cytidine acetyltransferase (hALP) DMOL5IU MT DME DMOL5IU MA Metabolism DMOL5IU RN NAT1 genotypes do not predict response to mesalamine in patients with ulcerative colitis. Z Gastroenterol. 2008 Mar;46(3):259-65. DMOL5IU RU https://www.ncbi.nlm.nih.gov/pubmed/?term=18322880 DM2ZGAN DI DM2ZGAN DM2ZGAN DN Mesoridazine DM2ZGAN MI DECB0K3 DM2ZGAN MN Cytochrome P450 2D6 (CYP2D6) DM2ZGAN MT DME DM2ZGAN MA Metabolism DM2ZGAN RN Thioridazine steady-state plasma concentrations are influenced by tobacco smoking and CYP2D6, but not by the CYP2C9 genotype. Eur J Clin Pharmacol. 2003 May;59(1):45-50. DM2ZGAN RU https://www.ncbi.nlm.nih.gov/pubmed/?term=12682803 DM2ZGAN DI DM2ZGAN DM2ZGAN DN Mesoridazine DM2ZGAN MI TTEX248 DM2ZGAN MN Dopamine D2 receptor (D2R) DM2ZGAN MT DTT DM2ZGAN MA Agonist DM2ZGAN RN Intrinsic efficacy of antipsychotics at human D2, D3, and D4 dopamine receptors: identification of the clozapine metabolite N-desmethylclozapine as... J Pharmacol Exp Ther. 2005 Dec;315(3):1278-87. DM2ZGAN RU https://pubmed.ncbi.nlm.nih.gov/16135699 DMG3F94 DI DMG3F94 DMG3F94 DN Mestranol DMG3F94 MI DES5XRU DMG3F94 MN Cytochrome P450 2C8 (CYP2C8) DMG3F94 MT DME DMG3F94 MA Metabolism DMG3F94 RN Loss of orally administered drugs in GI tract. Saudi Pharm J. 2012 Oct;20(4):331-44. DMG3F94 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=23960808 DMG3F94 DI DMG3F94 DMG3F94 DN Mestranol DMG3F94 MI DE5IED8 DMG3F94 MN Cytochrome P450 2C9 (CYP2C9) DMG3F94 MT DME DMG3F94 MA Metabolism DMG3F94 RN Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. DMG3F94 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=19515014 DMG3F94 DI DMG3F94 DMG3F94 DN Mestranol DMG3F94 MI DE4LYSA DMG3F94 MN Cytochrome P450 3A4 (CYP3A4) DMG3F94 MT DME DMG3F94 MA Metabolism DMG3F94 RN Prescribrt's digital referenve - Ethinyl estradiol/norethindrone; mestranol/norethindrone - Drug Summary DMG3F94 RU http://www.pdr.net/drug-summary/Necon-ethinyl-estradiol-norethindrone----mestranol-norethindrone-2049 DMG3F94 DI DMG3F94 DMG3F94 DN Mestranol DMG3F94 MI TTZAYWL DMG3F94 MN Estrogen receptor (ESR) DMG3F94 MT DTT DMG3F94 MA Agonist DMG3F94 RN Short-term effects of environmentally relevant concentrations of EDC mixtures on Mytilus galloprovincialis digestive gland. Aquat Toxicol. 2008 May 30;87(4):272-9. DMG3F94 RU https://pubmed.ncbi.nlm.nih.gov/18374427 DMM4QOJ DI DMM4QOJ DMM4QOJ DN Metadoxine DMM4QOJ MI TTPRKM0 DMM4QOJ MN GABA transporter GAT-1 (SLC6A1) DMM4QOJ MT DTT DMM4QOJ MA Modulator DMM4QOJ RN Company report (Alcobra pharma) DMM4QOJ RU http://www.alcobra-pharma.com/products.cfm?productID=163127 DMTQS9A DI DMTQS9A DMTQS9A DN Metaproterenol sulfate DMTQS9A MI TT2CJVK DMTQS9A MN Adrenergic receptor beta-2 (ADRB2) DMTQS9A MT DTT DMTQS9A MA Modulator DMTQS9A RN Male--female differences in the impact of beta-adrenoceptor stimulation on resistance to experimental metastasis: exploring the effects of age and ... J Neuroimmunol. 2008 Jan;193(1-2):113-9. DMTQS9A RU https://pubmed.ncbi.nlm.nih.gov/18037507 DMWIX23 DI DMWIX23 DMWIX23 DN Metaraminol DMWIX23 MI TTEX248 DMWIX23 MN Dopamine D2 receptor (D2R) DMWIX23 MT DTT DMWIX23 MA Agonist DMWIX23 RN Alpha1-adrenoceptor stimulation enhances experimental gastric carcinogenesis induced by N-methyl-N'-nitro-N-nitrosoguanidine in Wistar rats. Int J Cancer. 1998 Jul 29;77(3):467-9. DMWIX23 RU https://pubmed.ncbi.nlm.nih.gov/9663612 DMJFP6G DI DMJFP6G DMJFP6G DN Metergolin DMJFP6G MI TTK8CXU DMJFP6G MN 5-HT 1B receptor (HTR1B) DMJFP6G MT DTT DMJFP6G MA Antagonist DMJFP6G RN Two amino acid differences in the sixth transmembrane domain are partially responsible for the pharmacological differences between the 5-HT1D beta and 5-HT1E 5-hydroxytryptamine receptors. J Neurochem. 1996 Nov;67(5):2096-103. DMJFP6G RU https://pubmed.ncbi.nlm.nih.gov/8863519 DMJFP6G DI DMJFP6G DMJFP6G DN Metergolin DMJFP6G MI TT6MSOK DMJFP6G MN 5-HT 1D receptor (HTR1D) DMJFP6G MT DTT DMJFP6G MA Antagonist DMJFP6G RN Primary structure and functional characterization of a human 5-HT1D-type serotonin receptor. Mol Pharmacol. 1991 Aug;40(2):143-8. DMJFP6G RU https://pubmed.ncbi.nlm.nih.gov/1652050 DMJFP6G DI DMJFP6G DMJFP6G DN Metergolin DMJFP6G MI TTCPG9S DMJFP6G MN 5-HT 1E receptor (HTR1E) DMJFP6G MT DTT DMJFP6G MA Antagonist DMJFP6G RN Molecular cloning and pharmacological characterization of the guinea pig 5-HT1E receptor. Eur J Pharmacol. 2004 Jan 26;484(2-3):127-39. DMJFP6G RU https://pubmed.ncbi.nlm.nih.gov/14744596 DMJFP6G DI DMJFP6G DMJFP6G DN Metergolin DMJFP6G MI TT0MI3F DMJFP6G MN 5-HT 1F receptor (HTR1F) DMJFP6G MT DTT DMJFP6G MA Antagonist DMJFP6G RN Cloning and characterization of the guinea pig 5-HT1F receptor subtype: a comparison of the pharmacological profile to the human species homolog. Neuropharmacology. 1997 Apr-May;36(4-5):569-76. DMJFP6G RU https://pubmed.ncbi.nlm.nih.gov/9225282 DMJFP6G DI DMJFP6G DMJFP6G DN Metergolin DMJFP6G MI TTJQOD7 DMJFP6G MN 5-HT 2A receptor (HTR2A) DMJFP6G MT DTT DMJFP6G MA Antagonist DMJFP6G RN Pharmacological characterisation of the agonist radioligand binding site of 5-HT(2A), 5-HT(2B) and 5-HT(2C) receptors. Naunyn Schmiedebergs Arch Pharmacol. 2004 Aug;370(2):114-23. DMJFP6G RU https://pubmed.ncbi.nlm.nih.gov/15322733 DMJFP6G DI DMJFP6G DMJFP6G DN Metergolin DMJFP6G MI TT0K1SC DMJFP6G MN 5-HT 2B receptor (HTR2B) DMJFP6G MT DTT DMJFP6G MA Antagonist DMJFP6G RN Pharmacological characterisation of the agonist radioligand binding site of 5-HT(2A), 5-HT(2B) and 5-HT(2C) receptors. Naunyn Schmiedebergs Arch Pharmacol. 2004 Aug;370(2):114-23. DMJFP6G RU https://pubmed.ncbi.nlm.nih.gov/15322733 DMJFP6G DI DMJFP6G DMJFP6G DN Metergolin DMJFP6G MI TTWJBZ5 DMJFP6G MN 5-HT 2C receptor (HTR2C) DMJFP6G MT DTT DMJFP6G MA Antagonist DMJFP6G RN Pharmacological characterisation of the agonist radioligand binding site of 5-HT(2A), 5-HT(2B) and 5-HT(2C) receptors. Naunyn Schmiedebergs Arch Pharmacol. 2004 Aug;370(2):114-23. DMJFP6G RU https://pubmed.ncbi.nlm.nih.gov/15322733 DMJFP6G DI DMJFP6G DMJFP6G DN Metergolin DMJFP6G MI TTRUFDT DMJFP6G MN 5-HT 5A receptor (HTR5A) DMJFP6G MT DTT DMJFP6G MA Antagonist DMJFP6G RN Cloning and characterisation of the human 5-HT5A serotonin receptor. FEBS Lett. 1994 Dec 5;355(3):242-6. DMJFP6G RU https://pubmed.ncbi.nlm.nih.gov/7988681 DMJFP6G DI DMJFP6G DMJFP6G DN Metergolin DMJFP6G MI TT85JO3 DMJFP6G MN 5-HT receptor (5HTR) DMJFP6G MT DTT DMJFP6G MA Modulator DMJFP6G RN Natural products as sources of new drugs over the last 25 years. J Nat Prod. 2007 Mar;70(3):461-77. DMJFP6G RU https://pubmed.ncbi.nlm.nih.gov/17309302 DM89QE1 DI DM89QE1 DM89QE1 DN Metformin DM89QE1 MI TTY84UG DM89QE1 MN Acetyl-CoA carboxylase 2 (ACACB) DM89QE1 MT DTT DM89QE1 MA Activator DM89QE1 RN AMP-activated protein kinase-dependent and -independent mechanisms underlying in vitro antiglioma action of compound C. Biochem Pharmacol. 2009 Jun 1;77(11):1684-93. DM89QE1 RU https://pubmed.ncbi.nlm.nih.gov/19428322 DM89QE1 DI DM89QE1 DM89QE1 DN Metformin DM89QE1 MI DTI7UX6 DM89QE1 MN Breast cancer resistance protein (ABCG2) DM89QE1 MT DTP DM89QE1 MA Substrate DM89QE1 RN Role of human placental apical membrane transporters in the efflux of glyburide, rosiglitazone, and metformin. Am J Obstet Gynecol. 2010 Apr;202(4):383.e1-7. DM89QE1 RU http://www.ncbi.nlm.nih.gov/pubmed/20350646 DM89QE1 DI DM89QE1 DM89QE1 DN Metformin DM89QE1 MI DT3EAQP DM89QE1 MN Equilibrative nucleoside transporter 4 (SLC29A4) DM89QE1 MT DTP DM89QE1 MA Substrate DM89QE1 RN Metformin: from mechanisms of action to therapies. Cell Metab. 2014 Dec 2;20(6):953-66. DM89QE1 RU http://www.ncbi.nlm.nih.gov/pubmed/25456737 DM89QE1 DI DM89QE1 DM89QE1 DN Metformin DM89QE1 MI DTZGT0P DM89QE1 MN Multidrug and toxin extrusion protein 1 (SLC47A1) DM89QE1 MT DTP DM89QE1 MA Substrate DM89QE1 RN Human multidrug and toxin extrusion 1 (MATE1/SLC47A1) transporter: functional characterization, interaction with OCT2 (SLC22A2), and single nucleotide polymorphisms. Am J Physiol Renal Physiol. 2010 Apr;298(4):F997-F1005. DM89QE1 RU http://www.ncbi.nlm.nih.gov/pubmed/20053795 DM89QE1 DI DM89QE1 DM89QE1 DN Metformin DM89QE1 MI DT3TX4H DM89QE1 MN Multidrug and toxin extrusion protein 2 (SLC47A2) DM89QE1 MT DTP DM89QE1 MA Substrate DM89QE1 RN Substrate specificity of MATE1 and MATE2-K, human multidrug and toxin extrusions/H(+)-organic cation antiporters. Biochem Pharmacol. 2007 Jul 15;74(2):359-71. DM89QE1 RU http://www.ncbi.nlm.nih.gov/pubmed/17509534 DM89QE1 DI DM89QE1 DM89QE1 DN Metformin DM89QE1 MI DTT79CX DM89QE1 MN Organic cation transporter 1 (SLC22A1) DM89QE1 MT DTP DM89QE1 MA Substrate DM89QE1 RN Metformin is a superior substrate for renal organic cation transporter OCT2 rather than hepatic OCT1. Drug Metab Pharmacokinet. 2005 Oct;20(5):379-86. DM89QE1 RU http://www.ncbi.nlm.nih.gov/pubmed/16272756 DM89QE1 DI DM89QE1 DM89QE1 DN Metformin DM89QE1 MI DT9IDPW DM89QE1 MN Organic cation transporter 2 (SLC22A2) DM89QE1 MT DTP DM89QE1 MA Substrate DM89QE1 RN Metformin is a superior substrate for renal organic cation transporter OCT2 rather than hepatic OCT1. Drug Metab Pharmacokinet. 2005 Oct;20(5):379-86. DM89QE1 RU http://www.ncbi.nlm.nih.gov/pubmed/16272756 DM89QE1 DI DM89QE1 DM89QE1 DN Metformin DM89QE1 MI DT6201N DM89QE1 MN Organic cation transporter 3 (SLC22A3) DM89QE1 MT DTP DM89QE1 MA Substrate DM89QE1 RN Expression of organic cation transporters OCT1 (SLC22A1) and OCT3 (SLC22A3) is affected by genetic factors and cholestasis in human liver. Hepatology. 2009 Oct;50(4):1227-40. DM89QE1 RU http://www.ncbi.nlm.nih.gov/pubmed/19591196 DM89QE1 DI DM89QE1 DM89QE1 DN Metformin DM89QE1 MI TTMHCGA DM89QE1 MN Solute carrier family 47 member 1 (SLC47A1) DM89QE1 MT DTT DM89QE1 MA Modulator DM89QE1 RN Molecular cloning, functional characterization and tissue distribution of rat H+/organic cation antiporter MATE1. Pharm Res. 2006 Aug;23(8):1696-701. DM89QE1 RU https://pubmed.ncbi.nlm.nih.gov/16850272 DM89QE1 DI DM89QE1 DM89QE1 DN Metformin DM89QE1 MI DTLA4Q2 DM89QE1 MN Thiamine transporter 1 (SLC19A2) DM89QE1 MT DTP DM89QE1 MA Substrate DM89QE1 RN Metformin Is a Substrate and Inhibitor of the Human Thiamine Transporter, THTR-2 (SLC19A3). Mol Pharm. 2015 Dec 7;12(12):4301-10. DM89QE1 RU http://www.ncbi.nlm.nih.gov/pubmed/26528626 DM89QE1 DI DM89QE1 DM89QE1 DN Metformin DM89QE1 MI DT39CEA DM89QE1 MN Thiamine transporter 2 (SLC19A3) DM89QE1 MT DTP DM89QE1 MA Substrate DM89QE1 RN Metformin Is a Substrate and Inhibitor of the Human Thiamine Transporter, THTR-2 (SLC19A3). Mol Pharm. 2015 Dec 7;12(12):4301-10. DM89QE1 RU http://www.ncbi.nlm.nih.gov/pubmed/26528626 DMTPAM3 DI DMTPAM3 DMTPAM3 DN Metformin arginine-hemisuccinimide DMTPAM3 MI TTCBFJO DMTPAM3 MN Insulin receptor (INSR) DMTPAM3 MT DTT DMTPAM3 MA Inhibitor DMTPAM3 RN Metformin (Glucophage) inhibits tyrosine phosphatase activity to stimulate the insulin receptor tyrosine kinase. Biochem Pharmacol. 2004 Jun 1;67(11):2081-91. DMTPAM3 RU https://pubmed.ncbi.nlm.nih.gov/15135305 DMGS4QH DI DMGS4QH DMGS4QH DN Methacholine Chloride DMGS4QH MI TTYEG6Q DMGS4QH MN Muscarinic acetylcholine receptor M2 (CHRM2) DMGS4QH MT DTT DMGS4QH MA Inhibitor DMGS4QH RN 6beta-Acetoxynortropane: a potent muscarinic agonist with apparent selectivity toward M2-receptors. J Med Chem. 1998 Jun 4;41(12):2047-55. DMGS4QH RU https://pubmed.ncbi.nlm.nih.gov/9622546 DMGS4QH DI DMGS4QH DMGS4QH DN Methacholine Chloride DMGS4QH MI TTQ13Z5 DMGS4QH MN Muscarinic acetylcholine receptor M3 (CHRM3) DMGS4QH MT DTT DMGS4QH MA Modulator DMGS4QH RN Muscarinic M3-receptors mediate cholinergic synergism of mitogenesis in airway smooth muscle. Am J Respir Cell Mol Biol. 2003 Feb;28(2):257-62. DMGS4QH RU https://pubmed.ncbi.nlm.nih.gov/12540494 DMGS4QH DI DMGS4QH DMGS4QH DN Methacholine Chloride DMGS4QH MI TTQ3JTF DMGS4QH MN Muscarinic acetylcholine receptor M4 (CHRM4) DMGS4QH MT DTT DMGS4QH MA Inhibitor DMGS4QH RN 6beta-Acetoxynortropane: a potent muscarinic agonist with apparent selectivity toward M2-receptors. J Med Chem. 1998 Jun 4;41(12):2047-55. DMGS4QH RU https://pubmed.ncbi.nlm.nih.gov/9622546 DMAY96V DI DMAY96V DMAY96V DN Methacycline DMAY96V MI TTQ8KVI DMAY96V MN Staphylococcus 30S ribosomal subunit (Stap-coc pbp2) DMAY96V MT DTT DMAY96V MA Binder DMAY96V RN Tetracyclines and pulmonary inflammation. Endocr Metab Immune Disord Drug Targets. 2007 Dec;7(4):232-6. DMAY96V RU https://pubmed.ncbi.nlm.nih.gov/18220943 DMTW6IU DI DMTW6IU DMTW6IU DN Methadone DMTW6IU MI DEQX145 DMTW6IU MN Aromatase (CYP19A1) DMTW6IU MT DME DMTW6IU MA Metabolism DMTW6IU RN Bidirectional transfer of methadone across human placenta. Biochem Pharmacol. 2005 Jan 1;69(1):187-97. DMTW6IU RU https://www.ncbi.nlm.nih.gov/pubmed/?term=15588727 DMTW6IU DI DMTW6IU DMTW6IU DN Methadone DMTW6IU MI DEJGDUW DMTW6IU MN Cytochrome P450 1A2 (CYP1A2) DMTW6IU MT DME DMTW6IU MA Metabolism DMTW6IU RN Methadone--metabolism, pharmacokinetics and interactions. Pharmacol Res. 2004 Dec;50(6):551-9. DMTW6IU RU https://www.ncbi.nlm.nih.gov/pubmed/?term=15501692 DMTW6IU DI DMTW6IU DMTW6IU DN Methadone DMTW6IU MI DEPKLMQ DMTW6IU MN Cytochrome P450 2B6 (CYP2B6) DMTW6IU MT DME DMTW6IU MA Metabolism DMTW6IU RN Methadone metabolism and drug-drug interactions: in vitro and in vivo literature review. J Pharm Sci. 2018 Dec;107(12):2983-2991. DMTW6IU RU https://www.ncbi.nlm.nih.gov/pubmed/?term=30205091 DMTW6IU DI DMTW6IU DMTW6IU DN Methadone DMTW6IU MI DEZMWRE DMTW6IU MN Cytochrome P450 2C18 (CYP2C18) DMTW6IU MT DME DMTW6IU MA Metabolism DMTW6IU RN Involvement of cytochrome P450 3A4 enzyme in the N-demethylation of methadone in human liver microsomes. Chem Res Toxicol. 1996 Mar;9(2):365-73. DMTW6IU RU https://www.ncbi.nlm.nih.gov/pubmed/?term=8839037 DMTW6IU DI DMTW6IU DMTW6IU DN Methadone DMTW6IU MI DES5XRU DMTW6IU MN Cytochrome P450 2C8 (CYP2C8) DMTW6IU MT DME DMTW6IU MA Metabolism DMTW6IU RN Methadone metabolism and drug-drug interactions: in vitro and in vivo literature review. J Pharm Sci. 2018 Dec;107(12):2983-2991. DMTW6IU RU https://www.ncbi.nlm.nih.gov/pubmed/?term=30205091 DMTW6IU DI DMTW6IU DMTW6IU DN Methadone DMTW6IU MI DE5IED8 DMTW6IU MN Cytochrome P450 2C9 (CYP2C9) DMTW6IU MT DME DMTW6IU MA Metabolism DMTW6IU RN Methadone metabolism and drug-drug interactions: in vitro and in vivo literature review. J Pharm Sci. 2018 Dec;107(12):2983-2991. DMTW6IU RU https://www.ncbi.nlm.nih.gov/pubmed/?term=30205091 DMTW6IU DI DMTW6IU DMTW6IU DN Methadone DMTW6IU MI DECB0K3 DMTW6IU MN Cytochrome P450 2D6 (CYP2D6) DMTW6IU MT DME DMTW6IU MA Metabolism DMTW6IU RN Methadone metabolism and drug-drug interactions: in vitro and in vivo literature review. J Pharm Sci. 2018 Dec;107(12):2983-2991. DMTW6IU RU https://www.ncbi.nlm.nih.gov/pubmed/?term=30205091 DMTW6IU DI DMTW6IU DMTW6IU DN Methadone DMTW6IU MI DE4LYSA DMTW6IU MN Cytochrome P450 3A4 (CYP3A4) DMTW6IU MT DME DMTW6IU MA Metabolism DMTW6IU RN Methadone metabolism and drug-drug interactions: in vitro and in vivo literature review. J Pharm Sci. 2018 Dec;107(12):2983-2991. DMTW6IU RU https://www.ncbi.nlm.nih.gov/pubmed/?term=30205091 DMTW6IU DI DMTW6IU DMTW6IU DN Methadone DMTW6IU MI DERD86B DMTW6IU MN Cytochrome P450 3A7 (CYP3A7) DMTW6IU MT DME DMTW6IU MA Metabolism DMTW6IU RN Methadone metabolism and drug-drug interactions: in vitro and in vivo literature review. J Pharm Sci. 2018 Dec;107(12):2983-2991. DMTW6IU RU https://www.ncbi.nlm.nih.gov/pubmed/?term=30205091 DMTW6IU DI DMTW6IU DMTW6IU DN Methadone DMTW6IU MI DEGTFWK DMTW6IU MN Mephenytoin 4-hydroxylase (CYP2C19) DMTW6IU MT DME DMTW6IU MA Metabolism DMTW6IU RN Methadone metabolism and drug-drug interactions: in vitro and in vivo literature review. J Pharm Sci. 2018 Dec;107(12):2983-2991. DMTW6IU RU https://www.ncbi.nlm.nih.gov/pubmed/?term=30205091 DMTW6IU DI DMTW6IU DMTW6IU DN Methadone DMTW6IU MI TTN4QDT DMTW6IU MN Opioid receptor (OPR) DMTW6IU MT DTT DMTW6IU MA Agonist DMTW6IU RN Methadone treatment and its dangers. Medicina (Kaunas). 2009;45(5):419-25. DMTW6IU RU https://pubmed.ncbi.nlm.nih.gov/19535889 DMTW6IU DI DMTW6IU DMTW6IU DN Methadone DMTW6IU MI DTUGYRD DMTW6IU MN P-glycoprotein 1 (ABCB1) DMTW6IU MT DTP DMTW6IU MA Substrate DMTW6IU RN In vitro P-glycoprotein-mediated transport of (R)-, (S)-, (R,S)-methadone, LAAM and their main metabolites. Pharmacology. 2007;80(4):304-11. DMTW6IU RU http://www.ncbi.nlm.nih.gov/pubmed/17690563 DMIRMVB DI DMIRMVB DMIRMVB DN Methadyl Acetate DMIRMVB MI TTKWM86 DMIRMVB MN Opioid receptor mu (MOP) DMIRMVB MT DTT DMIRMVB MA Agonist DMIRMVB RN Acetylmethadol metabolites influence opiate receptors and adenylate cyclase in amygdala. Eur J Pharmacol. 1981 Jul 10;72(4):343-9. DMIRMVB RU https://pubmed.ncbi.nlm.nih.gov/6268422 DMPM4SK DI DMPM4SK DMPM4SK DN Methamphetamine DMPM4SK MI TTBRKXS DMPM4SK MN Adrenergic receptor alpha-1B (ADRA1B) DMPM4SK MT DTT DMPM4SK MA Antagonist DMPM4SK RN Mirtazapine treatment after conditioning with methamphetamine alters subsequent expression of place preference. Drug Alcohol Depend. 2009 Jan 1;99(1-3):231-9. DMPM4SK RU https://pubmed.ncbi.nlm.nih.gov/18945553 DMPM4SK DI DMPM4SK DMPM4SK DN Methamphetamine DMPM4SK MI DECB0K3 DMPM4SK MN Cytochrome P450 2D6 (CYP2D6) DMPM4SK MT DME DMPM4SK MA Metabolism DMPM4SK RN Cytochrome P450 2D6.1 and cytochrome P450 2D6.10 differ in catalytic activity for multiple substrates. Pharmacogenetics. 2001 Aug;11(6):477-87. DMPM4SK RU https://www.ncbi.nlm.nih.gov/pubmed/?term=11505218 DMPM4SK DI DMPM4SK DMPM4SK DN Methamphetamine DMPM4SK MI TTEX248 DMPM4SK MN Dopamine D2 receptor (D2R) DMPM4SK MT DTT DMPM4SK MA Agonist DMPM4SK RN Pharmacotherapy for obesity. Drugs. 2005;65(10):1391-418. DMPM4SK RU https://pubmed.ncbi.nlm.nih.gov/15977970 DMPM4SK DI DMPM4SK DMPM4SK DN Methamphetamine DMPM4SK MI DTT7VPB DMPM4SK MN Vesicular amine transporter 2 (SLC18A2) DMPM4SK MT DTP DMPM4SK MA Substrate DMPM4SK RN Synthesis and Discovery of Arylpiperidinylquinazolines: New Inhibitors of the Vesicular Monoamine Transporter. J Med Chem. 2018 Oct 25;61(20):9121-9131. DMPM4SK RU http://www.ncbi.nlm.nih.gov/pubmed/30240563 DMO2JBC DI DMO2JBC DMO2JBC DN Methamphetamine hydrochloride DMO2JBC MI DECB0K3 DMO2JBC MN Cytochrome P450 2D6 (CYP2D6) DMO2JBC MT DME DMO2JBC MA Metabolism DMO2JBC RN Cytochrome P450 2D6.1 and cytochrome P450 2D6.10 differ in catalytic activity for multiple substrates. Pharmacogenetics. 2001 Aug;11(6):477-87. DMO2JBC RU https://www.ncbi.nlm.nih.gov/pubmed/?term=11505218 DM8X4A1 DI DM8X4A1 DM8X4A1 DN Methantheline DM8X4A1 MI TTH18TF DM8X4A1 MN Muscarinic acetylcholine receptor M5 (CHRM5) DM8X4A1 MT DTT DM8X4A1 MA Antagonist DM8X4A1 RN Anticholinergics for urinary symptoms in multiple sclerosis. Cochrane Database Syst Rev. 2009 Jan 21;(1):CD004193. DM8X4A1 RU https://pubmed.ncbi.nlm.nih.gov/19160231 DM5A38V DI DM5A38V DM5A38V DN Metharbital DM5A38V MI TTEX6LM DM5A38V MN GABA(A) receptor gamma-3 (GABRG3) DM5A38V MT DTT DM5A38V MA Modulator DM5A38V RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. DM5A38V RU https://www.fda.gov/ DM7J2TA DI DM7J2TA DM7J2TA DN Methazolamide DM7J2TA MI TTHQPL7 DM7J2TA MN Carbonic anhydrase I (CA-I) DM7J2TA MT DTT DM7J2TA MA Modulator DM7J2TA RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2597). DM7J2TA RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2597 DMAUHQX DI DMAUHQX DMAUHQX DN Methdilazine DMAUHQX MI TTTIBOJ DMAUHQX MN Histamine H1 receptor (H1R) DMAUHQX MT DTT DMAUHQX MA Antagonist DMAUHQX RN Effect of H1 blockers alone and in combination with morphine to produce antinociception in mice. Neuropharmacology. 1985 Jan;24(1):1-4. DMAUHQX RU https://pubmed.ncbi.nlm.nih.gov/2858829 DM3Z217 DI DM3Z217 DM3Z217 DN Methimazole DM3Z217 MI DEIASEZ DM3Z217 MN Dimethylaniline oxidase 2 (FMO2) DM3Z217 MT DME DM3Z217 MA Metabolism DM3Z217 RN Drug metabolism by flavin-containing monooxygenases of human and mouse. Expert Opin Drug Metab Toxicol. 2017 Feb;13(2):167-181. DM3Z217 RU https://pubmed.ncbi.nlm.nih.gov/27678284 DM25FL8 DI DM25FL8 DM25FL8 DN Methimazole DM25FL8 MI TT52XDZ DM25FL8 MN Thyroid peroxidase (TPO) DM25FL8 MT DTT DM25FL8 MA Inhibitor DM25FL8 RN Diagnosis and treatment of thyrotoxicosis in childhood. A European questionnaire study. Eur J Endocrinol. 1994 Nov;131(5):467-73. DM25FL8 RU https://pubmed.ncbi.nlm.nih.gov/7952157 DM7YMIT DI DM7YMIT DM7YMIT DN Methohexital DM7YMIT MI TT1MPAY DM7YMIT MN GABA(A) receptor alpha-1 (GABRA1) DM7YMIT MT DTT DM7YMIT MA Antagonist DM7YMIT RN DrugBank: a knowledgebase for drugs, drug actions and drug targets. Nucleic Acids Res. 2008 Jan;36(Database issue):D901-6. DM7YMIT RU https://pubmed.ncbi.nlm.nih.gov/18048412 DM2TEOL DI DM2TEOL DM2TEOL DN Methotrexate DM2TEOL MI DTI7UX6 DM2TEOL MN Breast cancer resistance protein (ABCG2) DM2TEOL MT DTP DM2TEOL MA Substrate DM2TEOL RN Wild-type breast cancer resistance protein (BCRP/ABCG2) is a methotrexate polyglutamate transporter. Cancer Res. 2003 Sep 1;63(17):5538-43. DM2TEOL RU http://www.ncbi.nlm.nih.gov/pubmed/14500392 DM2TEOL DI DM2TEOL DM2TEOL DN Methotrexate DM2TEOL MI DE4EGMZ DM2TEOL MN Dihydrofolate reductase (DHFR) DM2TEOL MT DME DM2TEOL MA Metabolism DM2TEOL RN The pharmacogenetics of methotrexate. Rheumatology (Oxford). 2007 Oct;46(10):1520-4. DM2TEOL RU https://www.ncbi.nlm.nih.gov/pubmed/?term=17586865 DM2TEOL DI DM2TEOL DM2TEOL DN Methotrexate DM2TEOL MI DTOSN46 DM2TEOL MN Folate transporter 1 (SLC19A1) DM2TEOL MT DTP DM2TEOL MA Substrate DM2TEOL RN Biology of the major facilitative folate transporters SLC19A1 and SLC46A1. Curr Top Membr. 2014;73:175-204. DM2TEOL RU http://www.ncbi.nlm.nih.gov/pubmed/24745983 DM2TEOL DI DM2TEOL DM2TEOL DN Methotrexate DM2TEOL MI DECWT2V DM2TEOL MN Folylpolyglutamate synthase (FPGS) DM2TEOL MT DME DM2TEOL MA Metabolism DM2TEOL RN The pharmacogenetics of methotrexate. Rheumatology (Oxford). 2007 Oct;46(10):1520-4. DM2TEOL RU https://www.ncbi.nlm.nih.gov/pubmed/?term=17586865 DM2TEOL DI DM2TEOL DM2TEOL DN Methotrexate DM2TEOL MI DEU7MWJ DM2TEOL MN Gamma-Glu-X carboxypeptidase (GGH) DM2TEOL MT DME DM2TEOL MA Metabolism DM2TEOL RN The pharmacogenetics of methotrexate. Rheumatology (Oxford). 2007 Oct;46(10):1520-4. DM2TEOL RU https://www.ncbi.nlm.nih.gov/pubmed/?term=17586865 DM2TEOL DI DM2TEOL DM2TEOL DN Methotrexate DM2TEOL MI DEN8V7Z DM2TEOL MN Glutamate carboxypeptidase II (FOLH1) DM2TEOL MT DME DM2TEOL MA Metabolism DM2TEOL RN Understanding and managing methotrexate nephrotoxicity. Oncologist. 2006 Jun;11(6):694-703. DM2TEOL RU https://www.ncbi.nlm.nih.gov/pubmed/?term=16794248 DM2TEOL DI DM2TEOL DM2TEOL DN Methotrexate DM2TEOL MI DEOXTPZ DM2TEOL MN Methylenetetrahydrofolate reductase (MTHFR) DM2TEOL MT DME DM2TEOL MA Metabolism DM2TEOL RN The pharmacogenetics of methotrexate. Rheumatology (Oxford). 2007 Oct;46(10):1520-4. DM2TEOL RU https://www.ncbi.nlm.nih.gov/pubmed/?term=17586865 DM2TEOL DI DM2TEOL DM2TEOL DN Methotrexate DM2TEOL MI DTSYQGK DM2TEOL MN Multidrug resistance-associated protein 1 (ABCC1) DM2TEOL MT DTP DM2TEOL MA Substrate DM2TEOL RN Transport of methotrexate (MTX) and folates by multidrug resistance protein (MRP) 3 and MRP1: effect of polyglutamylation on MTX transport. Cancer Res. 2001 Oct 1;61(19):7225-32. DM2TEOL RU http://www.ncbi.nlm.nih.gov/pubmed/11585759 DM2TEOL DI DM2TEOL DM2TEOL DN Methotrexate DM2TEOL MI DTFI42L DM2TEOL MN Multidrug resistance-associated protein 2 (ABCC2) DM2TEOL MT DTP DM2TEOL MA Substrate DM2TEOL RN Dose-dependent disposition of methotrexate in Abcc2 and Abcc3 gene knockout murine models. Drug Metab Dispos. 2011 Nov;39(11):2155-61. DM2TEOL RU http://www.ncbi.nlm.nih.gov/pubmed/21841039 DM2TEOL DI DM2TEOL DM2TEOL DN Methotrexate DM2TEOL MI DTQ3ZHF DM2TEOL MN Multidrug resistance-associated protein 3 (ABCC3) DM2TEOL MT DTP DM2TEOL MA Substrate DM2TEOL RN Multidrug resistance protein (MRP) 1 and MRP3 attenuate cytotoxic and transactivating effects of the cyclopentenone prostaglandin, 15-deoxy-Delta(12,14)prostaglandin J2 in MCF7 breast cancer cells. Biochemistry. 2003 May 13;42(18):5429-37. DM2TEOL RU http://www.ncbi.nlm.nih.gov/pubmed/12731885 DM2TEOL DI DM2TEOL DM2TEOL DN Methotrexate DM2TEOL MI DTCSGPB DM2TEOL MN Multidrug resistance-associated protein 4 (ABCC4) DM2TEOL MT DTP DM2TEOL MA Substrate DM2TEOL RN Interaction of nonsteroidal anti-inflammatory drugs with multidrug resistance protein (MRP) 2/ABCC2- and MRP4/ABCC4-mediated methotrexate transport. J Pharmacol Exp Ther. 2007 Jan;320(1):229-35. DM2TEOL RU http://www.ncbi.nlm.nih.gov/pubmed/17005917 DM2TEOL DI DM2TEOL DM2TEOL DN Methotrexate DM2TEOL MI DTYVM24 DM2TEOL MN Multidrug resistance-associated protein 5 (ABCC5) DM2TEOL MT DTP DM2TEOL MA Substrate DM2TEOL RN The human multidrug resistance protein MRP5 transports folates and can mediate cellular resistance against antifolates. Cancer Res. 2005 May 15;65(10):4425-30. DM2TEOL RU http://www.ncbi.nlm.nih.gov/pubmed/15899835 DM2TEOL DI DM2TEOL DM2TEOL DN Methotrexate DM2TEOL MI DTWN7FC DM2TEOL MN Multidrug resistance-associated protein 8 (ABCC11) DM2TEOL MT DTP DM2TEOL MA Substrate DM2TEOL RN ABCC11/MRP8 confers pemetrexed resistance in lung cancer. Cancer Sci. 2010 Nov;101(11):2404-10. DM2TEOL RU http://www.ncbi.nlm.nih.gov/pubmed/20718756 DM2TEOL DI DM2TEOL DM2TEOL DN Methotrexate DM2TEOL MI DTQ23VB DM2TEOL MN Organic anion transporter 1 (SLC22A6) DM2TEOL MT DTP DM2TEOL MA Substrate DM2TEOL RN Transport of aminopterin by human organic anion transporters hOAT1 and hOAT3: Comparison with methotrexate. Drug Metab Pharmacokinet. 2010;25(2):163-9. DM2TEOL RU http://www.ncbi.nlm.nih.gov/pubmed/20460822 DM2TEOL DI DM2TEOL DM2TEOL DN Methotrexate DM2TEOL MI DT0OC1Q DM2TEOL MN Organic anion transporter 2 (SLC22A7) DM2TEOL MT DTP DM2TEOL MA Substrate DM2TEOL RN Transport of organic anions across the basolateral membrane of proximal tubule cells. Rev Physiol Biochem Pharmacol. 2003;146:95-158. DM2TEOL RU http://www.ncbi.nlm.nih.gov/pubmed/12605306 DM2TEOL DI DM2TEOL DM2TEOL DN Methotrexate DM2TEOL MI DTVP67E DM2TEOL MN Organic anion transporter 3 (SLC22A8) DM2TEOL MT DTP DM2TEOL MA Substrate DM2TEOL RN Methotrexate-loxoprofen interaction: involvement of human organic anion transporters hOAT1 and hOAT3. Drug Metab Pharmacokinet. 2004 Oct;19(5):369-74. DM2TEOL RU http://www.ncbi.nlm.nih.gov/pubmed/15548848 DM2TEOL DI DM2TEOL DM2TEOL DN Methotrexate DM2TEOL MI DT06JWZ DM2TEOL MN Organic anion transporter 4 (SLC22A11) DM2TEOL MT DTP DM2TEOL MA Substrate DM2TEOL RN Characterization of methotrexate transport and its drug interactions with human organic anion transporters. J Pharmacol Exp Ther. 2002 Aug;302(2):666-71. DM2TEOL RU http://www.ncbi.nlm.nih.gov/pubmed/12130730 DM2TEOL DI DM2TEOL DM2TEOL DN Methotrexate DM2TEOL MI DTE2B1D DM2TEOL MN Organic anion transporting polypeptide 1A2 (SLCO1A2) DM2TEOL MT DTP DM2TEOL MA Substrate DM2TEOL RN Interaction of methotrexate with organic-anion transporting polypeptide 1A2 and its genetic variants. J Pharmacol Exp Ther. 2006 Aug;318(2):521-9. DM2TEOL RU http://www.ncbi.nlm.nih.gov/pubmed/16702441 DM2TEOL DI DM2TEOL DM2TEOL DN Methotrexate DM2TEOL MI DT3D8F0 DM2TEOL MN Organic anion transporting polypeptide 1B1 (SLCO1B1) DM2TEOL MT DTP DM2TEOL MA Substrate DM2TEOL RN Preclinical Mouse Models To Study Human OATP1B1- and OATP1B3-Mediated Drug-Drug Interactions in Vivo. Mol Pharm. 2015 Dec 7;12(12):4259-69. DM2TEOL RU http://www.ncbi.nlm.nih.gov/pubmed/26474710 DM2TEOL DI DM2TEOL DM2TEOL DN Methotrexate DM2TEOL MI DT9C1TS DM2TEOL MN Organic anion transporting polypeptide 1B3 (SLCO1B3) DM2TEOL MT DTP DM2TEOL MA Substrate DM2TEOL RN LST-2, a human liver-specific organic anion transporter, determines methotrexate sensitivity in gastrointestinal cancers. Gastroenterology. 2001 Jun;120(7):1689-99. DM2TEOL RU http://www.ncbi.nlm.nih.gov/pubmed/11375950 DM2TEOL DI DM2TEOL DM2TEOL DN Methotrexate DM2TEOL MI DTUGYRD DM2TEOL MN P-glycoprotein 1 (ABCB1) DM2TEOL MT DTP DM2TEOL MA Substrate DM2TEOL RN Mammalian drug efflux transporters of the ATP binding cassette (ABC) family in multidrug resistance: A review of the past decade. Cancer Lett. 2016 Jan 1;370(1):153-64. DM2TEOL RU http://www.ncbi.nlm.nih.gov/pubmed/26499806 DM2TEOL DI DM2TEOL DM2TEOL DN Methotrexate DM2TEOL MI TTY8Z2E DM2TEOL MN Proton-coupled folate transporter (SLC46A1) DM2TEOL MT DTT DM2TEOL MA Modulator DM2TEOL RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1213). DM2TEOL RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1213 DM2TEOL DI DM2TEOL DM2TEOL DN Methotrexate DM2TEOL MI DTDJEMI DM2TEOL MN Proton-coupled folate transporter (SLC46A1) DM2TEOL MT DTP DM2TEOL MA Substrate DM2TEOL RN Site-specific contribution of proton-coupled folate transporter/haem carrier protein 1 in the intestinal absorption of methotrexate in rats. J Pharm Pharmacol. 2009 Jul;61(7):911-8. DM2TEOL RU http://www.ncbi.nlm.nih.gov/pubmed/19589233 DM2TEOL DI DM2TEOL DM2TEOL DN Methotrexate DM2TEOL MI TT09I7D DM2TEOL MN Solute carrier family 19 member 1 (SLC19A1) DM2TEOL MT DTT DM2TEOL MA Modulator DM2TEOL RN Increased activity of a novel low pH folate transporter associated with lipophilic antifolate resistance in chinese hamster ovary cells. J Biol Chem. 1998 Apr 3;273(14):8106-11. DM2TEOL RU https://pubmed.ncbi.nlm.nih.gov/9525913 DM2TEOL DI DM2TEOL DM2TEOL DN Methotrexate DM2TEOL MI DEFQ8VO DM2TEOL MN Thiopurine methyltransferase (TPMT) DM2TEOL MT DME DM2TEOL MA Metabolism DM2TEOL RN Genetics of rheumatoid arthritis. Mayo Clin Proc. 2006 Jan;81(1):94-101. DM2TEOL RU https://www.ncbi.nlm.nih.gov/pubmed/?term=16438485 DM2TEOL DI DM2TEOL DM2TEOL DN Methotrexate DM2TEOL MI DEASG0Q DM2TEOL MN Thymidylate synthase (TYMS) DM2TEOL MT DME DM2TEOL MA Metabolism DM2TEOL RN The pharmacogenetics of methotrexate. Rheumatology (Oxford). 2007 Oct;46(10):1520-4. DM2TEOL RU https://www.ncbi.nlm.nih.gov/pubmed/?term=17586865 DM5XH2C DI DM5XH2C DM5XH2C DN Methotrexate Sodium DM5XH2C MI TTYZVDJ DM5XH2C MN Dihydrofolate reductase (DHFR) DM5XH2C MT DTT DM5XH2C MA Modulator DM5XH2C RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. DM5XH2C RU https://www.fda.gov/ DMF5XQH DI DMF5XQH DMF5XQH DN Methoxamine DMF5XQH MI TTBRKXS DMF5XQH MN Adrenergic receptor alpha-1B (ADRA1B) DMF5XQH MT DTT DMF5XQH MA Stimulator DMF5XQH RN Activation of alpha1-adrenoceptors inhibits growth hormone secretion in humans. Exp Clin Endocrinol Diabetes. 2009 Oct;117(9):460-2. DMF5XQH RU https://pubmed.ncbi.nlm.nih.gov/19373756 DME8FZ9 DI DME8FZ9 DME8FZ9 DN Methoxsalen DME8FZ9 MI TTAQ6ZW DME8FZ9 MN Cytochrome P450 2A6 (CYP2A6) DME8FZ9 MT DTT DME8FZ9 MA Binder DME8FZ9 RN Mutagenicity and carcinogenicity of methoxsalen plus UV-A. Arch Dermatol. 1984 May;120(5):662-9. DME8FZ9 RU https://pubmed.ncbi.nlm.nih.gov/6372701 DME8FZ9 DI DME8FZ9 DME8FZ9 DN Methoxsalen DME8FZ9 MI DEJVYAZ DME8FZ9 MN Cytochrome P450 2A6 (CYP2A6) DME8FZ9 MT DME DME8FZ9 MA Metabolism DME8FZ9 RN Identification of the human cytochrome P450 enzymes involved in the in vitro metabolism of artemisinin. Br J Clin Pharmacol. 1999 Oct;48(4):528-35. DME8FZ9 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=10583023 DME8FZ9 DI DME8FZ9 DME8FZ9 DN Methoxsalen DME8FZ9 MI DE4LYSA DME8FZ9 MN Cytochrome P450 3A4 (CYP3A4) DME8FZ9 MT DME DME8FZ9 MA Metabolism DME8FZ9 RN Photochemotherapeutic agent 8-methoxypsoralen induces cytochrome P450 3A4 and carboxylesterase HCE2: evidence on an involvement of the pregnane X receptor. Toxicol Sci. 2007 Jan;95(1):13-22. DME8FZ9 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=17003103 DMK1LZD DI DMK1LZD DMK1LZD DN Methoxy polyethylene glycol-epoetin beta DMK1LZD MI TTAUX24 DMK1LZD MN Erythropoietin Receptor (EPOR) DMK1LZD MT DTT DMK1LZD MA Activator DMK1LZD RN 2007 FDA drug approvals: a year of flux. Nat Rev Drug Discov. 2008 Feb;7(2):107-9. DMK1LZD RU https://pubmed.ncbi.nlm.nih.gov/18246607 DML0RAE DI DML0RAE DML0RAE DN Methoxyflurane DML0RAE MI DEJGDUW DML0RAE MN Cytochrome P450 1A2 (CYP1A2) DML0RAE MT DME DML0RAE MA Metabolism DML0RAE RN Identification of cytochrome P450 2E1 as the predominant enzyme catalyzing human liver microsomal defluorination of sevoflurane, isoflurane, and methoxyflurane. Anesthesiology. 1993 Oct;79(4):795-807. DML0RAE RU https://www.ncbi.nlm.nih.gov/pubmed/?term=8214760 DML0RAE DI DML0RAE DML0RAE DN Methoxyflurane DML0RAE MI DEJVYAZ DML0RAE MN Cytochrome P450 2A6 (CYP2A6) DML0RAE MT DME DML0RAE MA Metabolism DML0RAE RN Human kidney methoxyflurane and sevoflurane metabolism. Intrarenal fluoride production as a possible mechanism of methoxyflurane nephrotoxicity. Anesthesiology. 1995 Mar;82(3):689-99. DML0RAE RU https://www.ncbi.nlm.nih.gov/pubmed/?term=7879937 DML0RAE DI DML0RAE DML0RAE DN Methoxyflurane DML0RAE MI DEPKLMQ DML0RAE MN Cytochrome P450 2B6 (CYP2B6) DML0RAE MT DME DML0RAE MA Metabolism DML0RAE RN Human kidney methoxyflurane and sevoflurane metabolism. Intrarenal fluoride production as a possible mechanism of methoxyflurane nephrotoxicity. Anesthesiology. 1995 Mar;82(3):689-99. DML0RAE RU https://www.ncbi.nlm.nih.gov/pubmed/?term=7879937 DML0RAE DI DML0RAE DML0RAE DN Methoxyflurane DML0RAE MI DE5IED8 DML0RAE MN Cytochrome P450 2C9 (CYP2C9) DML0RAE MT DME DML0RAE MA Metabolism DML0RAE RN Identification of cytochrome P450 2E1 as the predominant enzyme catalyzing human liver microsomal defluorination of sevoflurane, isoflurane, and methoxyflurane. Anesthesiology. 1993 Oct;79(4):795-807. DML0RAE RU https://www.ncbi.nlm.nih.gov/pubmed/?term=8214760 DML0RAE DI DML0RAE DML0RAE DN Methoxyflurane DML0RAE MI DECB0K3 DML0RAE MN Cytochrome P450 2D6 (CYP2D6) DML0RAE MT DME DML0RAE MA Metabolism DML0RAE RN Identification of cytochrome P450 2E1 as the predominant enzyme catalyzing human liver microsomal defluorination of sevoflurane, isoflurane, and methoxyflurane. Anesthesiology. 1993 Oct;79(4):795-807. DML0RAE RU https://www.ncbi.nlm.nih.gov/pubmed/?term=8214760 DML0RAE DI DML0RAE DML0RAE DN Methoxyflurane DML0RAE MI DEVDYN7 DML0RAE MN Cytochrome P450 2E1 (CYP2E1) DML0RAE MT DME DML0RAE MA Metabolism DML0RAE RN Construction and assessment of models of CYP2E1: predictions of metabolism from docking, molecular dynamics, and density functional theoretical calculations. J Med Chem. 2003 Apr 24;46(9):1645-60. DML0RAE RU https://www.ncbi.nlm.nih.gov/pubmed/?term=12699383 DML0RAE DI DML0RAE DML0RAE DN Methoxyflurane DML0RAE MI DE4LYSA DML0RAE MN Cytochrome P450 3A4 (CYP3A4) DML0RAE MT DME DML0RAE MA Metabolism DML0RAE RN Identification of cytochrome P450 2E1 as the predominant enzyme catalyzing human liver microsomal defluorination of sevoflurane, isoflurane, and methoxyflurane. Anesthesiology. 1993 Oct;79(4):795-807. DML0RAE RU https://www.ncbi.nlm.nih.gov/pubmed/?term=8214760 DML0RAE DI DML0RAE DML0RAE DN Methoxyflurane DML0RAE MI TT1MPAY DML0RAE MN GABA(A) receptor alpha-1 (GABRA1) DML0RAE MT DTT DML0RAE MA Antagonist DML0RAE RN DrugBank: a knowledgebase for drugs, drug actions and drug targets. Nucleic Acids Res. 2008 Jan;36(Database issue):D901-6. DML0RAE RU https://pubmed.ncbi.nlm.nih.gov/18048412 DMHP8FI DI DMHP8FI DMHP8FI DN Methscopolamine bromide DMHP8FI MI TTQ13Z5 DMHP8FI MN Muscarinic acetylcholine receptor M3 (CHRM3) DMHP8FI MT DTT DMHP8FI MA Modulator DMHP8FI RN Agonist-regulated alteration of the affinity of pancreatic muscarinic cholinergic receptors. J Biol Chem. 1993 Oct 25;268(30):22436-43. DMHP8FI RU https://www.ncbi.nlm.nih.gov/pubmed/7693670 DM6L5VO DI DM6L5VO DM6L5VO DN Methsuximide DM6L5VO MI DEGTFWK DM6L5VO MN Mephenytoin 4-hydroxylase (CYP2C19) DM6L5VO MT DME DM6L5VO MA Metabolism DM6L5VO RN The role of S-mephenytoin hydroxylase (CYP2C19) in the metabolism of the antimalarial biguanides. Br J Clin Pharmacol. 1995 Apr;39(4):441-4. DM6L5VO RU https://www.ncbi.nlm.nih.gov/pubmed/?term=7640152 DM6L5VO DI DM6L5VO DM6L5VO DN Methsuximide DM6L5VO MI TT729IR DM6L5VO MN Voltage-gated calcium channel alpha Cav3.1 (CACNA1G) DM6L5VO MT DTT DM6L5VO MA Blocker DM6L5VO RN Block of cloned human T-type calcium channels by succinimide antiepileptic drugs. Mol Pharmacol. 2001 Nov;60(5):1121-32. DM6L5VO RU https://pubmed.ncbi.nlm.nih.gov/11641441 DMN7SDE DI DMN7SDE DMN7SDE DN Methyclothiazide DMN7SDE MI TTS087L DMN7SDE MN Solute carrier family 12 member 1 (SLC12A1) DMN7SDE MT DTT DMN7SDE MA Blocker DMN7SDE RN DrugBank: a knowledgebase for drugs, drug actions and drug targets. Nucleic Acids Res. 2008 Jan;36(Database issue):D901-6. DMN7SDE RU https://pubmed.ncbi.nlm.nih.gov/18048412 DMIUX3D DI DMIUX3D DMIUX3D DN Methyl aminolevulinate DMIUX3D MI TTQ6VF4 DMIUX3D MN Ferrochelatase (FECH) DMIUX3D MT DTT DMIUX3D MA Activator DMIUX3D RN Low-dose methotrexate enhances aminolevulinate-based photodynamic therapy in skin carcinoma cells in vitro and in vivo. Clin Cancer Res. 2009 May 15;15(10):3333-43. DMIUX3D RU https://pubmed.ncbi.nlm.nih.gov/19447864 DM5I621 DI DM5I621 DM5I621 DN Methyldopa DM5I621 MI DEJGDUW DM5I621 MN Cytochrome P450 1A2 (CYP1A2) DM5I621 MT DME DM5I621 MA Metabolism DM5I621 RN Lack of interaction between amiodarone and mexiletine in cardiac arrhythmia patients. J Clin Pharmacol. 2002 Mar;42(3):342-6. DM5I621 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=11865972 DM5I621 DI DM5I621 DM5I621 DN Methyldopa DM5I621 MI DECB0K3 DM5I621 MN Cytochrome P450 2D6 (CYP2D6) DM5I621 MT DME DM5I621 MA Metabolism DM5I621 RN Lack of interaction between amiodarone and mexiletine in cardiac arrhythmia patients. J Clin Pharmacol. 2002 Mar;42(3):342-6. DM5I621 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=11865972 DM5I621 DI DM5I621 DM5I621 DN Methyldopa DM5I621 MI TTEX248 DM5I621 MN Dopamine D2 receptor (D2R) DM5I621 MT DTT DM5I621 MA Agonist DM5I621 RN Centrally acting antihypertensive agents: an update. J Clin Hypertens (Greenwich). 2007 May;9(5):399-405. DM5I621 RU https://pubmed.ncbi.nlm.nih.gov/17485976 DM5I621 DI DM5I621 DM5I621 DN Methyldopa DM5I621 MI DEYWLRK DM5I621 MN Sulfotransferase 1A1 (SULT1A1) DM5I621 MT DME DM5I621 MA Metabolism DM5I621 RN Platelet phenol sulfotransferase and erythrocyte catechol-O-methyltransferase activities: correlation with methyldopa metabolism. Clin Pharmacol Ther. 1984 Jan;35(1):55-63. DM5I621 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=6580988 DM5I621 DI DM5I621 DM5I621 DN Methyldopa DM5I621 MI DEFQ8VO DM5I621 MN Thiopurine methyltransferase (TPMT) DM5I621 MT DME DM5I621 MA Metabolism DM5I621 RN Identification, characterization, and ontogenic study of a catechol O-methyltransferase from zebrafish. Aquat Toxicol. 2011 Mar;102(1-2):18-23. DM5I621 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=21371608 DM8XI09 DI DM8XI09 DM8XI09 DN Methyldopate Hydrochloride DM8XI09 MI TTQ8AFT DM8XI09 MN Adrenergic receptor Alpha-2 (ADRA2) DM8XI09 MT DTT DM8XI09 MA Modulator DM8XI09 RN Effect of Antihypertensive Therapy with Alpha Methyldopa on Levels of Angiogenic Factors in Pregnancies with Hypertensive Disorders DM8XI09 RU https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2447877 DMJAPE7 DI DMJAPE7 DMJAPE7 DN Methylene blue DMJAPE7 MI TT6HPVC DMJAPE7 MN Guanylate cyclase (GC) DMJAPE7 MT DTT DMJAPE7 MA Inhibitor DMJAPE7 RN Curcumin ameliorates high glucose-induced acute vascular endothelial dysfunction in rat thoracic aorta. Clin Exp Pharmacol Physiol. 2009 Dec;36(12):1177-82. DMJAPE7 RU https://pubmed.ncbi.nlm.nih.gov/19473193 DMJAPE7 DI DMJAPE7 DMJAPE7 DN Methylene blue DMJAPE7 MI TT32XQJ DMJAPE7 MN Monoamine oxidase (MAO) DMJAPE7 MT DTT DMJAPE7 RN Photoluminescence of CdTe nanocrystals modulated by methylene blue and DNA. A label-free luminescent signaling nanohybrid platform. Phys Chem Chem Phys. 2009 Jul 7;11(25):5062-9. DMJAPE7 RU https://pubmed.ncbi.nlm.nih.gov/19562136 DMBEX4O DI DMBEX4O DMBEX4O DN Methylergonovine DMBEX4O MI DE4LYSA DMBEX4O MN Cytochrome P450 3A4 (CYP3A4) DMBEX4O MT DME DMBEX4O MA Metabolism DMBEX4O RN Modulation of cytochrome P450 metabolism by ergonovine and dihydroergotamine. Vet Hum Toxicol. 2003 Feb;45(1):6-9. DMBEX4O RU https://www.ncbi.nlm.nih.gov/pubmed/?term=12583687 DMBEX4O DI DMBEX4O DMBEX4O DN Methylergonovine DMBEX4O MI TTZFYLI DMBEX4O MN Dopamine D1 receptor (D1R) DMBEX4O MT DTT DMBEX4O MA Antagonist DMBEX4O RN Reinforcement in an in vitro analog of appetitive classical conditioning of feeding behavior in Aplysia: blockade by a dopamine antagonist. Learn Mem. 2005 May-Jun;12(3):216-20. DMBEX4O RU https://pubmed.ncbi.nlm.nih.gov/15930499 DMZTGN2 DI DMZTGN2 DMZTGN2 DN Methylnaltrexone bromide DMZTGN2 MI TTD0CIQ DMZTGN2 MN Melanocortin receptor 4 (MC4R) DMZTGN2 MT DTT DMZTGN2 MA Agonist DMZTGN2 RN Emerging drugs for obesity: linking novel biological mechanisms to pharmaceutical pipelines. Expert Opin Emerg Drugs. 2005 Aug;10(3):643-60. DMZTGN2 RU https://pubmed.ncbi.nlm.nih.gov/16083333 DMZTGN2 DI DMZTGN2 DMZTGN2 DN Methylnaltrexone bromide DMZTGN2 MI TTKWM86 DMZTGN2 MN Opioid receptor mu (MOP) DMZTGN2 MT DTT DMZTGN2 MA Modulator DMZTGN2 RN 2008 FDA drug approvals. Nat Rev Drug Discov. 2009 Feb;8(2):93-6. DMZTGN2 RU https://pubmed.ncbi.nlm.nih.gov/19180096 DM7SJD6 DI DM7SJD6 DM7SJD6 DN Methylphenidate DM7SJD6 MI DEB30C5 DM7SJD6 MN Carboxylesterase 1 (CES1) DM7SJD6 MT DME DM7SJD6 MA Metabolism DM7SJD6 RN Methylphenidate is stereoselectively hydrolyzed by human carboxylesterase CES1A1. J Pharmacol Exp Ther. 2004 Aug;310(2):469-76. DM7SJD6 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=15082749 DM7SJD6 DI DM7SJD6 DM7SJD6 DN Methylphenidate DM7SJD6 MI TTVBI8W DM7SJD6 MN Dopamine transporter (DAT) DM7SJD6 MT DTT DM7SJD6 MA Blocker DM7SJD6 RN Imaging the effects of methylphenidate on brain dopamine: new model on its therapeutic actions for attention-deficit/hyperactivity disorder. Biol Psychiatry. 2005 Jun 1;57(11):1410-5. DM7SJD6 RU https://pubmed.ncbi.nlm.nih.gov/15950015 DM7SJD6 DI DM7SJD6 DM7SJD6 DN Methylphenidate DM7SJD6 MI DTE8R17 DM7SJD6 MN Sodium- and chloride-dependent glycine transporter 2 (SLC6A5) DM7SJD6 MT DTP DM7SJD6 MA Substrate DM7SJD6 RN SLC6 transporters: structure, function, regulation, disease association and therapeutics. Mol Aspects Med. 2013 Apr-Jun;34(2-3):197-219. DM7SJD6 RU http://www.ncbi.nlm.nih.gov/pubmed/23506866 DMDSWAG DI DMDSWAG DMDSWAG DN Methylphenobarbital DMDSWAG MI DEPKLMQ DMDSWAG MN Cytochrome P450 2B6 (CYP2B6) DMDSWAG MT DME DMDSWAG MA Metabolism DMDSWAG RN Pharmacogenetic roles of CYP2C19 and CYP2B6 in the metabolism of R- and S-mephobarbital in humans. Pharmacogenetics. 2004 Aug;14(8):549-56. DMDSWAG RU https://www.ncbi.nlm.nih.gov/pubmed/?term=15284537 DMDSWAG DI DMDSWAG DMDSWAG DN Methylphenobarbital DMDSWAG MI TT1MPAY DMDSWAG MN GABA(A) receptor alpha-1 (GABRA1) DMDSWAG MT DTT DMDSWAG MA Antagonist DMDSWAG RN DrugBank: a knowledgebase for drugs, drug actions and drug targets. Nucleic Acids Res. 2008 Jan;36(Database issue):D901-6. DMDSWAG RU https://pubmed.ncbi.nlm.nih.gov/18048412 DMDSWAG DI DMDSWAG DMDSWAG DN Methylphenobarbital DMDSWAG MI DEGTFWK DMDSWAG MN Mephenytoin 4-hydroxylase (CYP2C19) DMDSWAG MT DME DMDSWAG MA Metabolism DMDSWAG RN A novel single nucleotide polymorphism (SNP) of the CYP2C19 gene in a Japanese subject with lowered capacity of mephobarbital 4'-hydroxylation. Drug Metab Pharmacokinet. 2004 Jun;19(3):236-8. DMDSWAG RU https://www.ncbi.nlm.nih.gov/pubmed/?term=15499191 DM4BDON DI DM4BDON DM4BDON DN Methylprednisolone DM4BDON MI DE4LYSA DM4BDON MN Cytochrome P450 3A4 (CYP3A4) DM4BDON MT DME DM4BDON MA Metabolism DM4BDON RN Cytochrome P450 enzyme regulation by glucocorticoids and consequences in terms of drug interaction. Expert Opin Drug Metab Toxicol. 2014 Mar;10(3):425-35. DM4BDON RU https://www.ncbi.nlm.nih.gov/pubmed/?term=24451000 DM4BDON DI DM4BDON DM4BDON DN Methylprednisolone DM4BDON MI TTYRL6O DM4BDON MN Glucocorticoid receptor (NR3C1) DM4BDON MT DTT DM4BDON MA Modulator DM4BDON RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. DM4BDON RU https://www.fda.gov/ DM4BDON DI DM4BDON DM4BDON DN Methylprednisolone DM4BDON MI DTUGYRD DM4BDON MN P-glycoprotein 1 (ABCB1) DM4BDON MT DTP DM4BDON MA Substrate DM4BDON RN Secretory transport of methylprednisolone possibly mediated by P-glycoprotein in Caco-2 cells. Biol Pharm Bull. 2002 Mar;25(3):393-6. DM4BDON RU http://www.ncbi.nlm.nih.gov/pubmed/11913542 DM5VWOB DI DM5VWOB DM5VWOB DN Methylscopolamine DM5VWOB MI TTOXS3C DM5VWOB MN Muscarinic acetylcholine receptor (CHRM) DM5VWOB MT DTT DM5VWOB MA Antagonist DM5VWOB RN Lithocholylcholine, a bile acid/acetylcholine hybrid, is a muscarinic receptor antagonist. J Pharmacol Exp Ther. 2002 Oct;303(1):29-35. DM5VWOB RU https://pubmed.ncbi.nlm.nih.gov/12235229 DM5VWOB DI DM5VWOB DM5VWOB DN Methylscopolamine DM5VWOB MI TTYEG6Q DM5VWOB MN Muscarinic acetylcholine receptor M2 (CHRM2) DM5VWOB MT DTT DM5VWOB MA Antagonist DM5VWOB RN Methylacridinium and its cholinergic properties. Neurotox Res. 2009 Nov;16(4):372-7. DM5VWOB RU https://pubmed.ncbi.nlm.nih.gov/19565307 DM5VWOB DI DM5VWOB DM5VWOB DN Methylscopolamine DM5VWOB MI TTQ13Z5 DM5VWOB MN Muscarinic acetylcholine receptor M3 (CHRM3) DM5VWOB MT DTT DM5VWOB MA Antagonist DM5VWOB RN Interaction of neuromuscular blocking drugs with recombinant human m1-m5 muscarinic receptors expressed in Chinese hamster ovary cells. Br J Pharmacol. 1998 Nov;125(5):1088-94. DM5VWOB RU https://pubmed.ncbi.nlm.nih.gov/9846649 DMWLFGO DI DMWLFGO DMWLFGO DN Methyltestosterone DMWLFGO MI DEPKLMQ DMWLFGO MN Cytochrome P450 2B6 (CYP2B6) DMWLFGO MT DME DMWLFGO MA Metabolism DMWLFGO RN Metabolism of anabolic steroids by recombinant human cytochrome P450 enzymes. Gas chromatographic-mass spectrometric determination of metabolites. J Chromatogr B Biomed Sci Appl. 1999 Nov 26;735(1):73-83. DMWLFGO RU https://www.ncbi.nlm.nih.gov/pubmed/?term=10630892 DMWLFGO DI DMWLFGO DMWLFGO DN Methyltestosterone DMWLFGO MI DE4LYSA DMWLFGO MN Cytochrome P450 3A4 (CYP3A4) DMWLFGO MT DME DMWLFGO MA Metabolism DMWLFGO RN Metabolism of anabolic steroids by recombinant human cytochrome P450 enzymes. Gas chromatographic-mass spectrometric determination of metabolites. J Chromatogr B Biomed Sci Appl. 1999 Nov 26;735(1):73-83. DMWLFGO RU https://www.ncbi.nlm.nih.gov/pubmed/?term=10630892 DMWLFGO DI DMWLFGO DMWLFGO DN Methyltestosterone DMWLFGO MI DEGKRXT DMWLFGO MN UDP-glucuronosyltransferase 2A1 (UGT2A1) DMWLFGO MT DME DMWLFGO MA Metabolism DMWLFGO RN Hepatic expression patterns of aryl hydrocarbon receptor, pregnane X receptor, two cytochrome P450s and five phase II metabolism genes responsive to 17alpha-methyltestosterone in rare minnow Gobiocypris rarus. Environ Toxicol Pharmacol. 2014 May;37(3):1157-68. DMWLFGO RU https://pubmed.ncbi.nlm.nih.gov/24814259 DMBW7VH DI DMBW7VH DMBW7VH DN Methyprylon DMBW7VH MI DECB0K3 DMBW7VH MN Cytochrome P450 2D6 (CYP2D6) DMBW7VH MT DME DMBW7VH MA Metabolism DMBW7VH RN Drugs and steatohepatitis. Semin Liver Dis. 2002;22(2):185-94. DMBW7VH RU https://www.ncbi.nlm.nih.gov/pubmed/?term=12016549 DMBW7VH DI DMBW7VH DMBW7VH DN Methyprylon DMBW7VH MI TT1MPAY DMBW7VH MN GABA(A) receptor alpha-1 (GABRA1) DMBW7VH MT DTT DMBW7VH MA Antagonist DMBW7VH RN DrugBank: a knowledgebase for drugs, drug actions and drug targets. Nucleic Acids Res. 2008 Jan;36(Database issue):D901-6. DMBW7VH RU https://pubmed.ncbi.nlm.nih.gov/18048412 DM1EF73 DI DM1EF73 DM1EF73 DN Methysergide DM1EF73 MI TTWJBZ5 DM1EF73 MN 5-HT 2C receptor (HTR2C) DM1EF73 MT DTT DM1EF73 MA Antagonist DM1EF73 RN Spinal serotonin receptor activation modulates the exercise ventilatory response with increased dead space in goats. Respir Physiol Neurobiol. 2008 May 31;161(3):230-8. DM1EF73 RU https://pubmed.ncbi.nlm.nih.gov/18396470 DM1EF73 DI DM1EF73 DM1EF73 DN Methysergide DM1EF73 MI DTUGYRD DM1EF73 MN P-glycoprotein 1 (ABCB1) DM1EF73 MT DTP DM1EF73 MA Substrate DM1EF73 RN Passive permeability and P-glycoprotein-mediated efflux differentiate central nervous system (CNS) and non-CNS marketed drugs. J Pharmacol Exp Ther. 2002 Dec;303(3):1029-37. DM1EF73 RU http://www.ncbi.nlm.nih.gov/pubmed/12438524 DMIKHN0 DI DMIKHN0 DMIKHN0 DN Meticillin DMIKHN0 MI TTJP4SM DMIKHN0 MN Bacterial Penicillin binding protein (Bact PBP) DMIKHN0 MT DTT DMIKHN0 MA Binder DMIKHN0 RN A link in transcription between the native pbpB and the acquired mecA gene in a strain of Staphylococcus aureus. Microbiology. 2006 Sep;152(Pt 9):2549-58. DMIKHN0 RU https://pubmed.ncbi.nlm.nih.gov/16946250 DMJMVKI DI DMJMVKI DMJMVKI DN Metipranolol DMJMVKI MI TTR6W5O DMJMVKI MN Adrenergic receptor beta-1 (ADRB1) DMJMVKI MT DTT DMJMVKI MA Antagonist DMJMVKI RN Invited review: Neuroprotective properties of certain beta-adrenoceptor antagonists used for the treatment of glaucoma. J Ocul Pharmacol Ther. 2005 Jun;21(3):175-81. DMJMVKI RU https://pubmed.ncbi.nlm.nih.gov/15969634 DMJMVKI DI DMJMVKI DMJMVKI DN Metipranolol DMJMVKI MI DECB0K3 DMJMVKI MN Cytochrome P450 2D6 (CYP2D6) DMJMVKI MT DME DMJMVKI MA Metabolism DMJMVKI RN Application of substrate depletion assay to evaluation of CYP isoforms responsible for stereoselective metabolism of carvedilol. Drug Metab Pharmacokinet. 2016 Dec;31(6):425-432. DMJMVKI RU https://www.ncbi.nlm.nih.gov/pubmed/?term=27836712 DM0JE6N DI DM0JE6N DM0JE6N DN Metixene DM0JE6N MI TTZ9SOR DM0JE6N MN Muscarinic acetylcholine receptor M1 (CHRM1) DM0JE6N MT DTT DM0JE6N MA Modulator DM0JE6N RN Roles of the M1 muscarinic acetylcholine receptor subtype in the regulation of basal ganglia function and implications for the treatment of Parkinson's disease.J Pharmacol Exp Ther.2012 Mar;340(3):595-603. DM0JE6N RU https://www.ncbi.nlm.nih.gov/pubmed/22135383 DMFA5MY DI DMFA5MY DMFA5MY DN Metoclopramide DMFA5MY MI DEJGDUW DMFA5MY MN Cytochrome P450 1A2 (CYP1A2) DMFA5MY MT DME DMFA5MY MA Metabolism DMFA5MY RN Metoclopramide is metabolized by CYP2D6 and is a reversible inhibitor, but not inactivator, of CYP2D6. Xenobiotica. 2014 Apr;44(4):309-319. DMFA5MY RU https://www.ncbi.nlm.nih.gov/pubmed/?term=24010633 DMFA5MY DI DMFA5MY DMFA5MY DN Metoclopramide DMFA5MY MI DECB0K3 DMFA5MY MN Cytochrome P450 2D6 (CYP2D6) DMFA5MY MT DME DMFA5MY MA Metabolism DMFA5MY RN Metoclopramide is metabolized by CYP2D6 and is a reversible inhibitor, but not inactivator, of CYP2D6. Xenobiotica. 2014 Apr;44(4):309-319. DMFA5MY RU https://www.ncbi.nlm.nih.gov/pubmed/?term=24010633 DMFA5MY DI DMFA5MY DMFA5MY DN Metoclopramide DMFA5MY MI DE4LYSA DMFA5MY MN Cytochrome P450 3A4 (CYP3A4) DMFA5MY MT DME DMFA5MY MA Metabolism DMFA5MY RN Metoclopramide is metabolized by CYP2D6 and is a reversible inhibitor, but not inactivator, of CYP2D6. Xenobiotica. 2014 Apr;44(4):309-319. DMFA5MY RU https://www.ncbi.nlm.nih.gov/pubmed/?term=24010633 DMFA5MY DI DMFA5MY DMFA5MY DN Metoclopramide DMFA5MY MI TTEX248 DMFA5MY MN Dopamine D2 receptor (D2R) DMFA5MY MT DTT DMFA5MY MA Antagonist DMFA5MY RN Mechanisms for metoclopramide-mediated sensitization and haloperidol-induced catalepsy in rats. Eur J Pharmacol. 2008 Jun 10;587(1-3):181-6. DMFA5MY RU https://pubmed.ncbi.nlm.nih.gov/18457824 DMFA5MY DI DMFA5MY DMFA5MY DN Metoclopramide DMFA5MY MI DTT79CX DMFA5MY MN Organic cation transporter 1 (SLC22A1) DMFA5MY MT DTP DMFA5MY MA Substrate DMFA5MY RN Identification of novel substrates and structure-activity relationship of cellular uptake mediated by human organic cation transporters 1 and 2. J Med Chem. 2013 Sep 26;56(18):7232-42. DMFA5MY RU http://www.ncbi.nlm.nih.gov/pubmed/23984907 DMZJYBW DI DMZJYBW DMZJYBW DN Metocurine Iodide DMZJYBW MI TTL1ATN DMZJYBW MN Neuronal acetylcholine receptor alpha-4/beta-2 (CHRNA4/B2) DMZJYBW MT DTT DMZJYBW MA Modulator DMZJYBW RN NMR study of general anesthetic interaction with nAChR beta2 subunit.Biophys J.2008 Mar 1;94(5):1681-8. DMZJYBW RU https://www.ncbi.nlm.nih.gov/pubmed/17993502 DMB39LO DI DMB39LO DMB39LO DN Metolazone DMB39LO MI TTP362L DMB39LO MN Solute carrier family 12 member 3 (SLC12A3) DMB39LO MT DTT DMB39LO MA Blocker DMB39LO RN The renal thiazide-sensitive Na-Cl cotransporter as mediator of the aldosterone-escape phenomenon. J Clin Invest. 2001 Jul;108(2):215-22. DMB39LO RU https://pubmed.ncbi.nlm.nih.gov/11457874 DMB39LO DI DMB39LO DMB39LO DN Metolazone DMB39LO MI DT6MDC9 DMB39LO MN Thiazide-sensitive sodium-chloride cotransporter (SLC12A3) DMB39LO MT DTP DMB39LO MA Substrate DMB39LO RN Inhibition of binding of [3H]metolazone to rat kidney membrane by stilbene disulfonates. Biochem Pharmacol. 1991 Jun 1;41(11):1745-50. DMB39LO RU http://www.ncbi.nlm.nih.gov/pubmed/2043163 DMOJ0V6 DI DMOJ0V6 DMOJ0V6 DN Metoprolol DMOJ0V6 MI TTR6W5O DMOJ0V6 MN Adrenergic receptor beta-1 (ADRB1) DMOJ0V6 MT DTT DMOJ0V6 MA Antagonist DMOJ0V6 RN Prediction and experimental validation of acute toxicity of beta-blockers in Ceriodaphnia dubia. Environ Toxicol Chem. 2005 Oct;24(10):2470-6. DMOJ0V6 RU https://pubmed.ncbi.nlm.nih.gov/16268148 DMOJ0V6 DI DMOJ0V6 DMOJ0V6 DN Metoprolol DMOJ0V6 MI DECB0K3 DMOJ0V6 MN Cytochrome P450 2D6 (CYP2D6) DMOJ0V6 MT DME DMOJ0V6 MA Metabolism DMOJ0V6 RN The impact of CYP2D6 mediated drug-drug interaction: a systematic review on a combination of metoprolol and paroxetine/fluoxetine. Br J Clin Pharmacol. 2018 Dec;84(12):2704-2715. DMOJ0V6 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=30248178 DMOJ0V6 DI DMOJ0V6 DMOJ0V6 DN Metoprolol DMOJ0V6 MI DE4LYSA DMOJ0V6 MN Cytochrome P450 3A4 (CYP3A4) DMOJ0V6 MT DME DMOJ0V6 MA Metabolism DMOJ0V6 RN Chemical stability-indicating HPLC study of fixed-dosage combination containing metoprolol tartrate and hydrochlorothiazide. DMOJ0V6 RU https://www.researchgate.net/publication/257614687_Chemical_stability-indicating_HPLC_study_of_fixed-dosage_combination_containing_metoprolol_tartrate_and_hydrochlorothiazide DMOJ0V6 DI DMOJ0V6 DMOJ0V6 DN Metoprolol DMOJ0V6 MI DEGTFWK DMOJ0V6 MN Mephenytoin 4-hydroxylase (CYP2C19) DMOJ0V6 MT DME DMOJ0V6 MA Metabolism DMOJ0V6 RN Summary of information on human CYP enzymes: human P450 metabolism data. Drug Metab Rev. 2002 Feb-May;34(1-2):83-448. DMOJ0V6 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=11996015 DMOJ0V6 DI DMOJ0V6 DMOJ0V6 DN Metoprolol DMOJ0V6 MI DT9G7XN DMOJ0V6 MN Peptide transporter 1 (SLC15A1) DMOJ0V6 MT DTP DMOJ0V6 MA Substrate DMOJ0V6 RN Peptide transporter substrate identification during permeability screening in drug discovery: comparison of transfected MDCK-hPepT1 cells to Caco-2 cells. Arch Pharm Res. 2007 Apr;30(4):507-18. DMOJ0V6 RU https://doi.org/10.1007/BF02980227 DM1NOEK DI DM1NOEK DM1NOEK DN Metreleptin DM1NOEK MI TT0HD6V DM1NOEK MN Leptin receptor (LEPR) DM1NOEK MT DTT DM1NOEK MA Modulator DM1NOEK RN 2014 FDA drug approvals. Nat Rev Drug Discov. 2015 Feb;14(2):77-81. DM1NOEK RU https://pubmed.ncbi.nlm.nih.gov/25633781 DMTIVEN DI DMTIVEN DMTIVEN DN Metronidazole DMTIVEN MI TTS1W4A DMTIVEN MN Bacterial Deoxyribonucleic acid (Bact DNA) DMTIVEN MT DTT DMTIVEN MA Modulator DMTIVEN RN DNA breakage due to metronidazole treatment. Mutat Res. 2001 Jul 1;478(1-2):153-8. DMTIVEN RU https://www.ncbi.nlm.nih.gov/pubmed/11406179 DMTIVEN DI DMTIVEN DMTIVEN DN Metronidazole DMTIVEN MI DEJVYAZ DMTIVEN MN Cytochrome P450 2A6 (CYP2A6) DMTIVEN MT DME DMTIVEN MA Metabolism DMTIVEN RN The role of human cytochrome P450 enzymes in the formation of 2-hydroxymetronidazole: CYP2A6 is the high affinity (low Km) catalyst. Drug Metab Dispos. 2013 Sep;41(9):1686-94. DMTIVEN RU https://www.ncbi.nlm.nih.gov/pubmed/?term=23813797 DMTIVEN DI DMTIVEN DMTIVEN DN Metronidazole DMTIVEN MI DE5IED8 DMTIVEN MN Cytochrome P450 2C9 (CYP2C9) DMTIVEN MT DME DMTIVEN MA Metabolism DMTIVEN RN Summary of information on human CYP enzymes: human P450 metabolism data. Drug Metab Rev. 2002 Feb-May;34(1-2):83-448. DMTIVEN RU https://www.ncbi.nlm.nih.gov/pubmed/?term=11996015 DMTIVEN DI DMTIVEN DMTIVEN DN Metronidazole DMTIVEN MI DE4LYSA DMTIVEN MN Cytochrome P450 3A4 (CYP3A4) DMTIVEN MT DME DMTIVEN MA Metabolism DMTIVEN RN Does metronidazole interact with CYP3A substrates by inhibiting their metabolism through this metabolic pathway? Or should other mechanisms be considered? Ann Pharmacother. 2007 Apr;41(4):653-8. DMTIVEN RU https://www.ncbi.nlm.nih.gov/pubmed/?term=17374625 DMTIVEN DI DMTIVEN DMTIVEN DN Metronidazole DMTIVEN MI DEIBDNY DMTIVEN MN Cytochrome P450 3A5 (CYP3A5) DMTIVEN MT DME DMTIVEN MA Metabolism DMTIVEN RN The role of human cytochrome P450 enzymes in the formation of 2-hydroxymetronidazole: CYP2A6 is the high affinity (low Km) catalyst. Drug Metab Dispos. 2013 Sep;41(9):1686-94. DMTIVEN RU https://www.ncbi.nlm.nih.gov/pubmed/?term=23813797 DMTIVEN DI DMTIVEN DMTIVEN DN Metronidazole DMTIVEN MI DERD86B DMTIVEN MN Cytochrome P450 3A7 (CYP3A7) DMTIVEN MT DME DMTIVEN MA Metabolism DMTIVEN RN The role of human cytochrome P450 enzymes in the formation of 2-hydroxymetronidazole: CYP2A6 is the high affinity (low Km) catalyst. Drug Metab Dispos. 2013 Sep;41(9):1686-94. DMTIVEN RU https://www.ncbi.nlm.nih.gov/pubmed/?term=23813797 DMTIVEN DI DMTIVEN DMTIVEN DN Metronidazole DMTIVEN MI DE8R7QY DMTIVEN MN Nitroreductase (NTR) DMTIVEN MT DME DMTIVEN MA Metabolism DMTIVEN RN Giardia, Entamoeba, and Trichomonas enzymes activate metronidazole (nitroreductases) and inactivate metronidazole (nitroimidazole reductases). Antimicrob Agents Chemother. 2009 Feb;53(2):458-64. DMTIVEN RU https://pubmed.ncbi.nlm.nih.gov/19015349 DMTIVEN DI DMTIVEN DMTIVEN DN Metronidazole DMTIVEN MI DE2VSMT DMTIVEN MN Nitroreductase (NTR) DMTIVEN MT DME DMTIVEN MA Metabolism DMTIVEN RN Giardia, Entamoeba, and Trichomonas enzymes activate metronidazole (nitroreductases) and inactivate metronidazole (nitroimidazole reductases). Antimicrob Agents Chemother. 2009 Feb;53(2):458-64. DMTIVEN RU https://pubmed.ncbi.nlm.nih.gov/19015349 DMTIVEN DI DMTIVEN DMTIVEN DN Metronidazole DMTIVEN MI DEQGIMN DMTIVEN MN Nitroreductase (NTR) DMTIVEN MT DME DMTIVEN MA Metabolism DMTIVEN RN Giardia, Entamoeba, and Trichomonas enzymes activate metronidazole (nitroreductases) and inactivate metronidazole (nitroimidazole reductases). Antimicrob Agents Chemother. 2009 Feb;53(2):458-64. DMTIVEN RU https://pubmed.ncbi.nlm.nih.gov/19015349 DMTIVEN DI DMTIVEN DMTIVEN DN Metronidazole DMTIVEN MI DEP7ECA DMTIVEN MN Nitroreductase (NTR) DMTIVEN MT DME DMTIVEN MA Metabolism DMTIVEN RN Acetamide--a metabolite of metronidazole formed by the intestinal flora. Biochem Pharmacol. 1979 Dec 15;28(24):3611-5. DMTIVEN RU https://pubmed.ncbi.nlm.nih.gov/231450 DMTIVEN DI DMTIVEN DMTIVEN DN Metronidazole DMTIVEN MI DEAN5EW DMTIVEN MN Nitroreductase (NTR) DMTIVEN MT DME DMTIVEN MA Metabolism DMTIVEN RN Overexpression, isotopic labeling, and spectral characterization of Enterobacter cloacae nitroreductase. Protein Expr Purif. 1998 Jun;13(1):53-60. DMTIVEN RU https://pubmed.ncbi.nlm.nih.gov/9631515 DMTIVEN DI DMTIVEN DMTIVEN DN Metronidazole DMTIVEN MI DE3U2Y6 DMTIVEN MN Nitroreductase (NTR) DMTIVEN MT DME DMTIVEN MA Metabolism DMTIVEN RN Mechanism of metronidazole-resistance by isolates of nitroreductase-producing Enterococcus gallinarum and Enterococcus casseliflavus from the human intestinal tract. FEMS Microbiol Lett. 2003 Aug 29;225(2):195-200. DMTIVEN RU https://pubmed.ncbi.nlm.nih.gov/12951241 DMTIVEN DI DMTIVEN DMTIVEN DN Metronidazole DMTIVEN MI DEUW4J0 DMTIVEN MN Nitroreductase (NTR) DMTIVEN MT DME DMTIVEN MA Metabolism DMTIVEN RN Mechanism of metronidazole-resistance by isolates of nitroreductase-producing Enterococcus gallinarum and Enterococcus casseliflavus from the human intestinal tract. FEMS Microbiol Lett. 2003 Aug 29;225(2):195-200. DMTIVEN RU https://pubmed.ncbi.nlm.nih.gov/12951241 DMTIVEN DI DMTIVEN DMTIVEN DN Metronidazole DMTIVEN MI DELAPDY DMTIVEN MN Nitroreductase (NTR) DMTIVEN MT DME DMTIVEN MA Metabolism DMTIVEN RN Isolation of metronidazole-resistant Bacteroides fragilis carrying the nimA nitroreductase gene from a patient in Washington State. J Clin Microbiol. 2004 Sep;42(9):4127-9. Case Reports DMTIVEN RU https://pubmed.ncbi.nlm.nih.gov/15364999 DMTIVEN DI DMTIVEN DMTIVEN DN Metronidazole DMTIVEN MI DEYGVN4 DMTIVEN MN UDP-glucuronosyltransferase 1A1 (UGT1A1) DMTIVEN MT DME DMTIVEN MA Metabolism DMTIVEN RN Drug-drug interactions for UDP-glucuronosyltransferase substrates: a pharmacokinetic explanation for typically observed low exposure (AUCi/AUC) ratios. Drug Metab Dispos. 2004 Nov;32(11):1201-8. DMTIVEN RU https://www.ncbi.nlm.nih.gov/pubmed/?term=15304429 DMI7FVQ DI DMI7FVQ DMI7FVQ DN Metyrapone DMI7FVQ MI TTIQUX7 DMI7FVQ MN Steroid 11-beta-hydroxylase (CYP11B1) DMI7FVQ MT DTT DMI7FVQ MA Inhibitor DMI7FVQ RN Effects of 3-MeSO2-DDE and some CYP inhibitors on glucocorticoid steroidogenesis in the H295R human adrenocortical carcinoma cell line. Toxicol In Vitro. 2002 Apr;16(2):113-21. DMI7FVQ RU https://pubmed.ncbi.nlm.nih.gov/11869873 DMBYCU0 DI DMBYCU0 DMBYCU0 DN Metyrosine DMBYCU0 MI TTUHP71 DMBYCU0 MN Tyrosine 3-monooxygenase (TH) DMBYCU0 MT DTT DMBYCU0 MA Binder DMBYCU0 RN Dopamine beta-hydroxylase deficiency. A genetic disorder of cardiovascular regulation. Hypertension. 1991 Jul;18(1):1-8. DMBYCU0 RU https://pubmed.ncbi.nlm.nih.gov/1677640 DMCTE9R DI DMCTE9R DMCTE9R DN Mexiletine DMCTE9R MI DEJGDUW DMCTE9R MN Cytochrome P450 1A2 (CYP1A2) DMCTE9R MT DME DMCTE9R MA Metabolism DMCTE9R RN Inhibition of human liver cytochrome P-450 1A2 by the class IB antiarrhythmics mexiletine, lidocaine, and tocainide. J Pharmacol Exp Ther. 1999 May;289(2):853-8. DMCTE9R RU https://www.ncbi.nlm.nih.gov/pubmed/?term=10215663 DMCTE9R DI DMCTE9R DMCTE9R DN Mexiletine DMCTE9R MI DEPKLMQ DMCTE9R MN Cytochrome P450 2B6 (CYP2B6) DMCTE9R MT DME DMCTE9R MA Metabolism DMCTE9R RN Role of specific cytochrome P450 enzymes in the N-oxidation of the antiarrhythmic agent mexiletine. Xenobiotica. 2003 Jan;33(1):13-25. DMCTE9R RU https://www.ncbi.nlm.nih.gov/pubmed/?term=12519691 DMCTE9R DI DMCTE9R DMCTE9R DN Mexiletine DMCTE9R MI DECB0K3 DMCTE9R MN Cytochrome P450 2D6 (CYP2D6) DMCTE9R MT DME DMCTE9R MA Metabolism DMCTE9R RN Impact of CYP2D6*10 on mexiletine pharmacokinetics in healthy adult volunteers. Eur J Clin Pharmacol. 2003 Sep;59(5-6):395-9. DMCTE9R RU https://www.ncbi.nlm.nih.gov/pubmed/?term=12937870 DMCTE9R DI DMCTE9R DMCTE9R DN Mexiletine DMCTE9R MI DEVDYN7 DMCTE9R MN Cytochrome P450 2E1 (CYP2E1) DMCTE9R MT DME DMCTE9R MA Metabolism DMCTE9R RN Role of specific cytochrome P450 enzymes in the N-oxidation of the antiarrhythmic agent mexiletine. Xenobiotica. 2003 Jan;33(1):13-25. DMCTE9R RU https://www.ncbi.nlm.nih.gov/pubmed/?term=12519691 DMCTE9R DI DMCTE9R DMCTE9R DN Mexiletine DMCTE9R MI DE4LYSA DMCTE9R MN Cytochrome P450 3A4 (CYP3A4) DMCTE9R MT DME DMCTE9R MA Metabolism DMCTE9R RN Pharmacokinetic and pharmacodynamic interaction between mexiletine and propafenone in human beings. Clin Pharmacol Ther. 2000 Jul;68(1):44-57. DMCTE9R RU https://www.ncbi.nlm.nih.gov/pubmed/?term=10945315 DMCTE9R DI DMCTE9R DMCTE9R DN Mexiletine DMCTE9R MI TTZOVE0 DMCTE9R MN Voltage-gated sodium channel alpha Nav1.5 (SCN5A) DMCTE9R MT DTT DMCTE9R MA Blocker DMCTE9R RN Effect of sodium channel blockers on ST segment, QRS duration, and corrected QT interval in patients with Brugada syndrome. J Cardiovasc Electrophysiol. 2000 Dec;11(12):1320-9. DMCTE9R RU https://pubmed.ncbi.nlm.nih.gov/11196553 DMY5JEP DI DMY5JEP DMY5JEP DN Mezlocillin DMY5JEP MI TT85JMW DMY5JEP MN Bacterial Penicillin binding protein 3 (Bact mrcA) DMY5JEP MT DTT DMY5JEP MA Binder DMY5JEP RN Bactericidal effect of piperacillin alone and combined. Presse Med. 1986 Dec 20;15(46):2297-302. DMY5JEP RU https://pubmed.ncbi.nlm.nih.gov/2949271 DMVKA4O DI DMVKA4O DMVKA4O DN Mianserin DMVKA4O MI TTYSN63 DMVKA4O MN 5-HT 2 receptor (5HT2R) DMVKA4O MT DTT DMVKA4O MA Antagonist DMVKA4O RN 5-HT reuptake and 5-HT2 receptors modulate capsaicin-evoked hypothermia in rats. Neurosci Lett. 2008 Jan 17;430(3):191-6. DMVKA4O RU https://pubmed.ncbi.nlm.nih.gov/18155835 DMVKA4O DI DMVKA4O DMVKA4O DN Mianserin DMVKA4O MI DEJGDUW DMVKA4O MN Cytochrome P450 1A2 (CYP1A2) DMVKA4O MT DME DMVKA4O MA Metabolism DMVKA4O RN Identification of human cytochrome P450 isoforms involved in the stereoselective metabolism of mianserin enantiomers. J Pharmacol Exp Ther. 1996 Jul;278(1):21-30. DMVKA4O RU https://www.ncbi.nlm.nih.gov/pubmed/?term=8764331 DMVKA4O DI DMVKA4O DMVKA4O DN Mianserin DMVKA4O MI DEPKLMQ DMVKA4O MN Cytochrome P450 2B6 (CYP2B6) DMVKA4O MT DME DMVKA4O MA Metabolism DMVKA4O RN Bupropion and 4-OH-bupropion pharmacokinetics in relation to genetic polymorphisms in CYP2B6. Pharmacogenetics. 2003 Oct;13(10):619-26. DMVKA4O RU https://www.ncbi.nlm.nih.gov/pubmed/?term=14515060 DMVKA4O DI DMVKA4O DMVKA4O DN Mianserin DMVKA4O MI DECB0K3 DMVKA4O MN Cytochrome P450 2D6 (CYP2D6) DMVKA4O MT DME DMVKA4O MA Metabolism DMVKA4O RN Assessment of CYP2D6 activity as a form of optimizing antidepressant therapy. Psychiatr Pol. 2004 Nov-Dec;38(6):1093-104. DMVKA4O RU https://www.ncbi.nlm.nih.gov/pubmed/?term=15779673 DMVKA4O DI DMVKA4O DMVKA4O DN Mianserin DMVKA4O MI DE4LYSA DMVKA4O MN Cytochrome P450 3A4 (CYP3A4) DMVKA4O MT DME DMVKA4O MA Metabolism DMVKA4O RN [Metabolic interaction between psychopharmaceuticals. Probable cause of exacerbation of hypothyroidism according to a case report]. Lakartidningen. 2002 Jun 20;99(25):2854-6. DMVKA4O RU https://www.ncbi.nlm.nih.gov/pubmed/?term=12143142 DM6Y3AN DI DM6Y3AN DM6Y3AN DN Micafungin DM6Y3AN MI DEJ6FSR DM6Y3AN MN Arylsulfatase A (ARSA) DM6Y3AN MT DME DM6Y3AN MA Metabolism DM6Y3AN RN The echinocandin micafungin: a review of the pharmacology, spectrum of activity, clinical efficacy and safety. Expert Opin Pharmacother. 2007 Jun;8(8):1155-66. DM6Y3AN RU https://www.ncbi.nlm.nih.gov/pubmed/?term=17516879 DM6Y3AN DI DM6Y3AN DM6Y3AN DN Micafungin DM6Y3AN MI TT0SFXH DM6Y3AN MN Fungal 1,3-beta-glucan synthase (Fung GSC2) DM6Y3AN MT DTT DM6Y3AN MA Modulator DM6Y3AN RN An immunomodulatory activity of micafungin in preclinical aspergillosis. J Antimicrob Chemother. 2014 Apr;69(4):1065-74. DM6Y3AN RU https://pubmed.ncbi.nlm.nih.gov/24265229 DM3O6CY DI DM3O6CY DM3O6CY DN Micardis telmisartan DM3O6CY MI TT8DBY3 DM3O6CY MN Angiotensin II receptor type-1 (AGTR1) DM3O6CY MT DTT DM3O6CY MA Antagonist DM3O6CY RN The angiotensin II receptor antagonist telmisartan reduces urinary albumin excretion in patients with isolated systolic hypertension: results of a randomized, double-blind, placebo-controlled trial. J Hypertens. 2005 Nov;23(11):2055-61. DM3O6CY RU https://pubmed.ncbi.nlm.nih.gov/16208149 DMPMYE8 DI DMPMYE8 DMPMYE8 DN Miconazole DMPMYE8 MI TTTSOUD DMPMYE8 MN Candida Cytochrome P450 51 (Candi ERG11) DMPMYE8 MT DTT DMPMYE8 MA Modulator DMPMYE8 RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. DMPMYE8 RU https://www.fda.gov/ DMPMYE8 DI DMPMYE8 DMPMYE8 DN Miconazole DMPMYE8 MI DE4LYSA DMPMYE8 MN Cytochrome P450 3A4 (CYP3A4) DMPMYE8 MT DME DMPMYE8 MA Metabolism DMPMYE8 RN Inhibition of cytochrome P450 enzymes participating in p-nitrophenol hydroxylation by drugs known as CYP2E1 inhibitors. Chem Biol Interact. 2004 Apr 15;147(3):331-40. DMPMYE8 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=15135088 DMXOELT DI DMXOELT DMXOELT DN Midazolam DMXOELT MI DEPKLMQ DMXOELT MN Cytochrome P450 2B6 (CYP2B6) DMXOELT MT DME DMXOELT MA Metabolism DMXOELT RN Further characterization of the expression in liver and catalytic activity of CYP2B6. J Pharmacol Exp Ther. 1998 Sep;286(3):1253-9. DMXOELT RU https://www.ncbi.nlm.nih.gov/pubmed/?term=9732386 DMXOELT DI DMXOELT DMXOELT DN Midazolam DMXOELT MI DE4LYSA DMXOELT MN Cytochrome P450 3A4 (CYP3A4) DMXOELT MT DME DMXOELT MA Metabolism DMXOELT RN Selection of alternative CYP3A4 probe substrates for clinical drug interaction studies using in vitro data and in vivo simulation. Drug Metab Dispos. 2010 Jun;38(6):981-7. DMXOELT RU https://www.ncbi.nlm.nih.gov/pubmed/?term=20203109 DMXOELT DI DMXOELT DMXOELT DN Midazolam DMXOELT MI DEIBDNY DMXOELT MN Cytochrome P450 3A5 (CYP3A5) DMXOELT MT DME DMXOELT MA Metabolism DMXOELT RN In vitro metabolism of midazolam, triazolam, nifedipine, and testosterone by human liver microsomes and recombinant cytochromes p450: role of cyp3a4 and cyp3a5. Drug Metab Dispos. 2003 Jul;31(7):938-44. DMXOELT RU https://www.ncbi.nlm.nih.gov/pubmed/?term=12814972 DMXOELT DI DMXOELT DMXOELT DN Midazolam DMXOELT MI DERD86B DMXOELT MN Cytochrome P450 3A7 (CYP3A7) DMXOELT MT DME DMXOELT MA Metabolism DMXOELT RN Summary of information on human CYP enzymes: human P450 metabolism data. Drug Metab Rev. 2002 Feb-May;34(1-2):83-448. DMXOELT RU https://www.ncbi.nlm.nih.gov/pubmed/?term=11996015 DMXOELT DI DMXOELT DMXOELT DN Midazolam DMXOELT MI DEMF740 DMXOELT MN Cytochrome P450 4B1 (CYP4B1) DMXOELT MT DME DMXOELT MA Metabolism DMXOELT RN Summary of information on human CYP enzymes: human P450 metabolism data. Drug Metab Rev. 2002 Feb-May;34(1-2):83-448. DMXOELT RU https://www.ncbi.nlm.nih.gov/pubmed/?term=11996015 DMXOELT DI DMXOELT DMXOELT DN Midazolam DMXOELT MI DTUGYRD DMXOELT MN P-glycoprotein 1 (ABCB1) DMXOELT MT DTP DMXOELT MA Substrate DMXOELT RN A novel screening strategy to identify ABCB1 substrates and inhibitors. Naunyn Schmiedebergs Arch Pharmacol. 2009 Jan;379(1):11-26. DMXOELT RU https://doi.org/10.1007/s00210-008-0345-0 DMXOELT DI DMXOELT DMXOELT DN Midazolam DMXOELT MI TTPTXIN DMXOELT MN Translocator protein (TSPO) DMXOELT MT DTT DMXOELT MA Modulator DMXOELT RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. DMXOELT RU https://www.fda.gov/ DME2PY5 DI DME2PY5 DME2PY5 DN Midodrine DME2PY5 MI TTG28O6 DME2PY5 MN Adrenergic receptor Alpha-1 (ADRA1) DME2PY5 MT DTT DME2PY5 MA Agonist DME2PY5 RN Orthostatic hypotension in patients with Parkinson's disease: pathophysiology and management. Drugs Aging. 2001;18(7):495-505. DME2PY5 RU https://pubmed.ncbi.nlm.nih.gov/11482743 DME2PY5 DI DME2PY5 DME2PY5 DN Midodrine DME2PY5 MI DECB0K3 DME2PY5 MN Cytochrome P450 2D6 (CYP2D6) DME2PY5 MT DME DME2PY5 MA Metabolism DME2PY5 RN Akathisia with combined use of midodrine and promethazine. JAMA. 2006 May 3;295(17):2000-1. Letter DME2PY5 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=16670408 DME2PY5 DI DME2PY5 DME2PY5 DN Midodrine DME2PY5 MI DT9G7XN DME2PY5 MN Peptide transporter 1 (SLC15A1) DME2PY5 MT DTP DME2PY5 MA Substrate DME2PY5 RN Transport characteristics of a novel peptide transporter 1 substrate, antihypotensive drug midodrine, and its amino acid derivatives. J Pharmacol Exp Ther. 2006 Jul;318(1):455-60. DME2PY5 RU http://www.ncbi.nlm.nih.gov/pubmed/16597710 DMI6E0R DI DMI6E0R DMI6E0R DN Midostaurin DMI6E0R MI DE4LYSA DMI6E0R MN Cytochrome P450 3A4 (CYP3A4) DMI6E0R MT DME DMI6E0R MA Metabolism DMI6E0R RN Midostaurin, a novel protein kinase inhibitor for the treatment of acute myelogenous leukemia: insights from human absorption, metabolism, and excretion studies of a BDDCS II drug. Drug Metab Dispos. 2017 May;45(5):540-555. DMI6E0R RU https://www.ncbi.nlm.nih.gov/pubmed/?term=28270565 DMI6E0R DI DMI6E0R DMI6E0R DN Midostaurin DMI6E0R MI TTGJCWZ DMI6E0R MN Fms-like tyrosine kinase 3 (FLT-3) DMI6E0R MT DTT DMI6E0R MA Inhibitor DMI6E0R RN A comparison of physicochemical property profiles of marketed oral drugs and orally bioavailable anti-cancer protein kinase inhibitors in clinical development. Curr Top Med Chem. 2007;7(14):1408-22. DMI6E0R RU https://pubmed.ncbi.nlm.nih.gov/17692029 DMI6E0R DI DMI6E0R DMI6E0R DN Midostaurin DMI6E0R MI DTUGYRD DMI6E0R MN P-glycoprotein 1 (ABCB1) DMI6E0R MT DTP DMI6E0R MA Substrate DMI6E0R RN Human intestinal transporter database: QSAR modeling and virtual profiling of drug uptake, efflux and interactions. Pharm Res. 2013 Apr;30(4):996-1007. DMI6E0R RU https://doi.org/10.1007/s11095-012-0935-x DMI6E0R DI DMI6E0R DMI6E0R DN Midostaurin DMI6E0R MI TTRFOXJ DMI6E0R MN Protein kinase C gamma (PRKCG) DMI6E0R MT DTT DMI6E0R MA Inhibitor DMI6E0R RN A comparison of physicochemical property profiles of marketed oral drugs and orally bioavailable anti-cancer protein kinase inhibitors in clinical development. Curr Top Med Chem. 2007;7(14):1408-22. DMI6E0R RU https://pubmed.ncbi.nlm.nih.gov/17692029 DMGZQEF DI DMGZQEF DMGZQEF DN Mifepristone DMGZQEF MI DE4LYSA DMGZQEF MN Cytochrome P450 3A4 (CYP3A4) DMGZQEF MT DME DMGZQEF MA Metabolism DMGZQEF RN Evaluation of strategies for the assessment of drug-drug interactions involving cytochrome P450 enzymes. Eur J Drug Metab Pharmacokinet. 2018 Dec;43(6):737-750. DMGZQEF RU https://www.ncbi.nlm.nih.gov/pubmed/?term=29785610 DMGZQEF DI DMGZQEF DMGZQEF DN Mifepristone DMGZQEF MI DEIBDNY DMGZQEF MN Cytochrome P450 3A5 (CYP3A5) DMGZQEF MT DME DMGZQEF MA Metabolism DMGZQEF RN Comparative analysis of substrate and inhibitor interactions with CYP3A4 and CYP3A5. Xenobiotica. 2006 Apr;36(4):287-99. DMGZQEF RU https://www.ncbi.nlm.nih.gov/pubmed/?term=16684709 DMGZQEF DI DMGZQEF DMGZQEF DN Mifepristone DMGZQEF MI TTYRL6O DMGZQEF MN Glucocorticoid receptor (NR3C1) DMGZQEF MT DTT DMGZQEF MA Modulator DMGZQEF RN The glucocorticoid agonist activities of mifepristone (RU486) and progesterone are dependent on glucocorticoid receptor levels but not on EC50 values. Steroids. 2007 Jun;72(6-7):600-8. DMGZQEF RU https://pubmed.ncbi.nlm.nih.gov/17509631 DMFIQ2H DI DMFIQ2H DMFIQ2H DN Migalastat DMFIQ2H MI TTIS03D DMFIQ2H MN Alpha-galactosidase A (GLA) DMFIQ2H MT DTT DMFIQ2H MA Modulator DMFIQ2H RN AT-1001: a high-affinity alpha3beta4 nAChR ligand with novel nicotine-suppressive pharmacology. Br J Pharmacol. 2015 Apr;172(7):1834-45. DMFIQ2H RU https://pubmed.ncbi.nlm.nih.gov/25440006 DMXBQAM DI DMXBQAM DMXBQAM DN Miglitol DMXBQAM MI TTXWASR DMXBQAM MN Intestinal maltase-glucoamylase (MGAM) DMXBQAM MT DTT DMXBQAM MA Inhibitor DMXBQAM RN Drug therapy of postprandial hyperglycaemia. Drugs. 1999 Jan;57(1):19-29. DMXBQAM RU https://pubmed.ncbi.nlm.nih.gov/9951949 DM5J64S DI DM5J64S DM5J64S DN Miglustat DM5J64S MI TTPHEX3 DM5J64S MN Ceramide glucosyltransferase (UGCG) DM5J64S MT DTT DM5J64S MA Inhibitor DM5J64S RN Effect of miglustat on bone disease in adults with type 1 Gaucher disease: a pooled analysis of three multinational, open-label studies. Clin Ther. 2007 Aug;29(8):1645-54. DM5J64S RU https://pubmed.ncbi.nlm.nih.gov/17919546 DMBFE74 DI DMBFE74 DMBFE74 DN Milnacipran DMBFE74 MI TTAWNKZ DMBFE74 MN Norepinephrine transporter (NET) DMBFE74 MT DTT DMBFE74 MA Inhibitor DMBFE74 RN Milnacipran: beyond a role of antidepressant. Clin Neuropharmacol. 2009 Nov-Dec;32(6):355-63. DMBFE74 RU https://pubmed.ncbi.nlm.nih.gov/19620845 DM8TUPF DI DM8TUPF DM8TUPF DN Milrinone DM8TUPF MI TTZCG4L DM8TUPF MN Phosphodiesterase 3 (PDE3) DM8TUPF MT DTT DM8TUPF MA Modulator DM8TUPF RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. DM8TUPF RU https://www.fda.gov/ DMND304 DI DMND304 DMND304 DN Miltefosine DMND304 MI DEB2ZMT DMND304 MN Choline phosphatase 1 (PLD1) DMND304 MT DME DMND304 MA Metabolism DMND304 RN Development of miltefosine as an oral treatment for leishmaniasis. Trans R Soc Trop Med Hyg. 2006 Dec;100 Suppl 1:S17-20. DMND304 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=16730362 DMND304 DI DMND304 DMND304 DN Miltefosine DMND304 MI TT9V5JH DMND304 MN Phospholipase A2 (PLA2G1B) DMND304 MT DTT DMND304 MA Inhibitor DMND304 RN Novel antifungal agents, targets or therapeutic strategies for the treatment of invasive fungal diseases: a review of the literature (2005-2009). Rev Iberoam Micol. 2009 Mar 31;26(1):15-22. DMND304 RU https://pubmed.ncbi.nlm.nih.gov/19463273 DM0EP7M DI DM0EP7M DM0EP7M DN Minaprine DM0EP7M MI TT0K1SC DM0EP7M MN 5-HT 2B receptor (HTR2B) DM0EP7M MT DTT DM0EP7M MA Antagonist DM0EP7M RN Privileged structures: a useful concept for the rational design of new lead drug candidates. Mini Rev Med Chem. 2007 Nov;7(11):1108-19. DM0EP7M RU https://pubmed.ncbi.nlm.nih.gov/18045214 DM0EP7M DI DM0EP7M DM0EP7M DN Minaprine DM0EP7M MI DECB0K3 DM0EP7M MN Cytochrome P450 2D6 (CYP2D6) DM0EP7M MT DME DM0EP7M MA Metabolism DM0EP7M RN Comparative molecular field analysis and QSAR on substrates binding to cytochrome p450 2D6. Bioorg Med Chem. 2003 Dec 1;11(24):5545-54. DM0EP7M RU https://www.ncbi.nlm.nih.gov/pubmed/?term=14642599 DMVN5OH DI DMVN5OH DMVN5OH DN Minocycline DMVN5OH MI TTQ8KVI DMVN5OH MN Staphylococcus 30S ribosomal subunit (Stap-coc pbp2) DMVN5OH MT DTT DMVN5OH MA Binder DMVN5OH RN Functional, biophysical, and structural bases for antibacterial activity of tigecycline. Antimicrob Agents Chemother. 2006 Jun;50(6):2156-66. DMVN5OH RU https://pubmed.ncbi.nlm.nih.gov/16723578 DM50PMY DI DM50PMY DM50PMY DN Minodronate DM50PMY MI TTIKWV4 DM50PMY MN Geranyltranstransferase (FDPS) DM50PMY MT DTT DM50PMY MA Inhibitor DM50PMY RN Synthesis, chiral high performance liquid chromatographic resolution and enantiospecific activity of a potent new geranylgeranyl transferase inhibitor, 2-hydroxy-3-imidazo[1,2-a]pyridin-3-yl-2-phosphonopropionic acid. J Med Chem. 2010 May 13;53(9):3454-64. DM50PMY RU https://pubmed.ncbi.nlm.nih.gov/20394422 DMA2Z4F DI DMA2Z4F DMA2Z4F DN Minoxidil DMA2Z4F MI TT1VOHK DMA2Z4F MN Potassium channel unspecific (KC) DMA2Z4F MT DTT DMA2Z4F MA Modulator DMA2Z4F RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. DMA2Z4F RU https://www.fda.gov/ DMA2Z4F DI DMA2Z4F DMA2Z4F DN Minoxidil DMA2Z4F MI DEYWLRK DMA2Z4F MN Sulfotransferase 1A1 (SULT1A1) DMA2Z4F MT DME DMA2Z4F MA Metabolism DMA2Z4F RN Sulfation of minoxidil by multiple human cytosolic sulfotransferases. Chem Biol Interact. 1998 Feb 20;109(1-3):53-67. DMA2Z4F RU https://www.ncbi.nlm.nih.gov/pubmed/?term=9566733 DMA2Z4F DI DMA2Z4F DMA2Z4F DN Minoxidil DMA2Z4F MI DEYGVN4 DMA2Z4F MN UDP-glucuronosyltransferase 1A1 (UGT1A1) DMA2Z4F MT DME DMA2Z4F MA Metabolism DMA2Z4F RN Human udp-glucuronosyltransferases: isoform selectivity and kinetics of 4-methylumbelliferone and 1-naphthol glucuronidation, effects of organic solvents, and inhibition by diclofenac and probenecid. Drug Metab Dispos. 2004 Apr;32(4):413-23. DMA2Z4F RU https://www.ncbi.nlm.nih.gov/pubmed/?term=15039294 DMGSRN1 DI DMGSRN1 DMGSRN1 DN Mipomersen DMGSRN1 MI TTN1IE2 DMGSRN1 MN APOB messenger RNA (APOB mRNA) DMGSRN1 MT DTT DMGSRN1 RN Design and development of antisense drugs. Expert Opin. Drug Discov. 2008 3(10):1189-1207. DMGSRN1 RU http://www.informahealthcare.com/doi/abs/10.1517/17460441.3.10.1177 DMS1GYT DI DMS1GYT DMS1GYT DN Mirabegron DMS1GYT MI TTMXGCW DMS1GYT MN Adrenergic receptor beta-3 (ADRB3) DMS1GYT MT DTT DMS1GYT MA Modulator DMS1GYT RN Nat Rev Drug Discov. 2013 Feb;12(2):87-90. DMS1GYT RU https://pubmed.ncbi.nlm.nih.gov/23370234 DMS1GYT DI DMS1GYT DMS1GYT DN Mirabegron DMS1GYT MI DECB0K3 DMS1GYT MN Cytochrome P450 2D6 (CYP2D6) DMS1GYT MT DME DMS1GYT MA Metabolism DMS1GYT RN Role of cytochrome p450 isoenzymes 3A and 2D6 in the in vivo metabolism of mirabegron, a beta-3-adrenoceptor agonist. Clin Drug Investig. 2013 Jun;33(6):429-40. DMS1GYT RU https://www.ncbi.nlm.nih.gov/pubmed/?term=23625188 DMS1GYT DI DMS1GYT DMS1GYT DN Mirabegron DMS1GYT MI DE4LYSA DMS1GYT MN Cytochrome P450 3A4 (CYP3A4) DMS1GYT MT DME DMS1GYT MA Metabolism DMS1GYT RN Role of cytochrome p450 isoenzymes 3A and 2D6 in the in vivo metabolism of mirabegron, a beta-3-adrenoceptor agonist. Clin Drug Investig. 2013 Jun;33(6):429-40. DMS1GYT RU https://www.ncbi.nlm.nih.gov/pubmed/?term=23625188 DML53ZJ DI DML53ZJ DML53ZJ DN Mirtazapine DML53ZJ MI TTWJBZ5 DML53ZJ MN 5-HT 2C receptor (HTR2C) DML53ZJ MT DTT DML53ZJ MA Antagonist DML53ZJ RN Inverse agonist and neutral antagonist actions of antidepressants at recombinant and native 5-hydroxytryptamine2C receptors: differential modulatio... Mol Pharmacol. 2008 Mar;73(3):748-57. DML53ZJ RU https://pubmed.ncbi.nlm.nih.gov/18083778 DML53ZJ DI DML53ZJ DML53ZJ DN Mirtazapine DML53ZJ MI DEJGDUW DML53ZJ MN Cytochrome P450 1A2 (CYP1A2) DML53ZJ MT DME DML53ZJ MA Metabolism DML53ZJ RN Impact of the CYP2D6 ultrarapid metabolizer genotype on mirtazapine pharmacokinetics and adverse events in healthy volunteers. J Clin Psychopharmacol. 2004 Dec;24(6):647-52. DML53ZJ RU https://www.ncbi.nlm.nih.gov/pubmed/?term=15538128 DML53ZJ DI DML53ZJ DML53ZJ DN Mirtazapine DML53ZJ MI DES5XRU DML53ZJ MN Cytochrome P450 2C8 (CYP2C8) DML53ZJ MT DME DML53ZJ MA Metabolism DML53ZJ RN Summary of information on human CYP enzymes: human P450 metabolism data. Drug Metab Rev. 2002 Feb-May;34(1-2):83-448. DML53ZJ RU https://www.ncbi.nlm.nih.gov/pubmed/?term=11996015 DML53ZJ DI DML53ZJ DML53ZJ DN Mirtazapine DML53ZJ MI DE5IED8 DML53ZJ MN Cytochrome P450 2C9 (CYP2C9) DML53ZJ MT DME DML53ZJ MA Metabolism DML53ZJ RN Summary of information on human CYP enzymes: human P450 metabolism data. Drug Metab Rev. 2002 Feb-May;34(1-2):83-448. DML53ZJ RU https://www.ncbi.nlm.nih.gov/pubmed/?term=11996015 DML53ZJ DI DML53ZJ DML53ZJ DN Mirtazapine DML53ZJ MI DECB0K3 DML53ZJ MN Cytochrome P450 2D6 (CYP2D6) DML53ZJ MT DME DML53ZJ MA Metabolism DML53ZJ RN A review of the pharmacological and clinical profile of mirtazapine. CNS Drug Rev. 2001 Fall;7(3):249-64. DML53ZJ RU https://www.ncbi.nlm.nih.gov/pubmed/?term=11607047 DML53ZJ DI DML53ZJ DML53ZJ DN Mirtazapine DML53ZJ MI DE4LYSA DML53ZJ MN Cytochrome P450 3A4 (CYP3A4) DML53ZJ MT DME DML53ZJ MA Metabolism DML53ZJ RN A review of the pharmacological and clinical profile of mirtazapine. CNS Drug Rev. 2001 Fall;7(3):249-64. DML53ZJ RU https://www.ncbi.nlm.nih.gov/pubmed/?term=11607047 DMHVJFK DI DMHVJFK DMHVJFK DN Misoprostol DMHVJFK MI TTOFYT1 DMHVJFK MN Prostacyclin receptor (PTGIR) DMHVJFK MT DTT DMHVJFK MA Antagonist DMHVJFK RN Palmitoylation of the human prostacyclin receptor. Functional implications of palmitoylation and isoprenylation. J Biol Chem. 2003 Feb 28;278(9):6947-58. DMHVJFK RU https://pubmed.ncbi.nlm.nih.gov/12488443 DMP8HEL DI DMP8HEL DMP8HEL DN Mitiglinide DMP8HEL MI TTG140O DMP8HEL MN Inward rectifier potassium channel Kir1.2 (KCNJ10) DMP8HEL MT DTT DMP8HEL MA Blocker DMP8HEL RN Carboxyl-glucuronidation of mitiglinide by human UDP-glucuronosyltransferases. Biochem Pharmacol. 2007 Jun 1;73(11):1842-51. DMP8HEL RU https://pubmed.ncbi.nlm.nih.gov/17359941 DMP8HEL DI DMP8HEL DMP8HEL DN Mitiglinide DMP8HEL MI DEF2WXN DMP8HEL MN UDP-glucuronosyltransferase 1A3 (UGT1A3) DMP8HEL MT DME DMP8HEL MA Metabolism DMP8HEL RN Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. DMP8HEL RU https://www.ncbi.nlm.nih.gov/pubmed/?term=19515014 DMH0ZJE DI DMH0ZJE DMH0ZJE DN Mitomycin DMH0ZJE MI TTUTN1I DMH0ZJE MN Human Deoxyribonucleic acid (hDNA) DMH0ZJE MT DTT DMH0ZJE MA Binder DMH0ZJE RN Assessment of cell viability, lipid peroxidation and quantification of DNA fragmentation after the treatment of anticancerous drug mitomycin C and ... Exp Toxicol Pathol. 2010 Sep;62(5):503-8. DMH0ZJE RU https://pubmed.ncbi.nlm.nih.gov/19608391 DMH0ZJE DI DMH0ZJE DMH0ZJE DN Mitomycin DMH0ZJE MI DTUGYRD DMH0ZJE MN P-glycoprotein 1 (ABCB1) DMH0ZJE MT DTP DMH0ZJE MA Substrate DMH0ZJE RN In vivo expansion of MDR1-transduced cells accompanied by a post-transplantation chemotherapy regimen with mitomycin C and methotrexate. J Gene Med. 2010 Jul;12(7):596-603. DMH0ZJE RU http://www.ncbi.nlm.nih.gov/pubmed/20533531 DM4PF81 DI DM4PF81 DM4PF81 DN Mitomycin A DM4PF81 MI TTUTN1I DM4PF81 MN Human Deoxyribonucleic acid (hDNA) DM4PF81 MT DTT DM4PF81 RN Selective activation of mitomycin A by thiols to form DNA cross-links and monoadducts: biochemical basis for the modulation of mitomycin cytotoxicity by the quinone redox potential. J Med Chem. 2001 Aug 16;44(17):2834-42. DM4PF81 RU https://pubmed.ncbi.nlm.nih.gov/11495594 DMU1GX0 DI DMU1GX0 DMU1GX0 DN Mitotane DMU1GX0 MI TTZAYWL DMU1GX0 MN Estrogen receptor (ESR) DMU1GX0 MT DTT DMU1GX0 MA Binder DMU1GX0 RN Mitotane for adrenocortical carcinoma treatment. Curr Opin Investig Drugs. 2005 Apr;6(4):386-94. DMU1GX0 RU https://pubmed.ncbi.nlm.nih.gov/15898346 DMM39BF DI DMM39BF DMM39BF DN Mitoxantrone DMM39BF MI DT2T6VQ DMM39BF MN ATP-binding cassette sub-family A member 3 (ABCA3) DMM39BF MT DTP DMM39BF MA Substrate DMM39BF RN A distinct "side population" of cells with high drug efflux capacity in human tumor cells. Proc Natl Acad Sci U S A. 2004 Sep 28;101(39):14228-33. DMM39BF RU http://www.ncbi.nlm.nih.gov/pubmed/15381773 DMM39BF DI DMM39BF DMM39BF DN Mitoxantrone DMM39BF MI DTI7UX6 DMM39BF MN Breast cancer resistance protein (ABCG2) DMM39BF MT DTP DMM39BF MA Substrate DMM39BF RN Functional characterization of the human multidrug transporter, ABCG2, expressed in insect cells. Biochem Biophys Res Commun. 2001 Jul 6;285(1):111-7. DMM39BF RU http://www.ncbi.nlm.nih.gov/pubmed/11437380 DMM39BF DI DMM39BF DMM39BF DN Mitoxantrone DMM39BF MI DEVDYN7 DMM39BF MN Cytochrome P450 2E1 (CYP2E1) DMM39BF MT DME DMM39BF MA Metabolism DMM39BF RN FDA label of Mitoxantrone. The 2020 official website of the U.S. Food and Drug Administration. DMM39BF RU https://www.accessdata.fda.gov/drugsatfda_docs/label/2012/019297s035lbl.pdf DMM39BF DI DMM39BF DMM39BF DN Mitoxantrone DMM39BF MI TT0IHXV DMM39BF MN DNA topoisomerase II (TOP2) DMM39BF MT DTT DMM39BF MA Modulator DMM39BF RN Mitoxantrone, a topoisomerase II inhibitor, induces apoptosis of B-chronic lymphocytic leukaemia cells. Br J Haematol. 1998 Jan;100(1):142-6. DMM39BF RU https://pubmed.ncbi.nlm.nih.gov/9450803 DMM39BF DI DMM39BF DMM39BF DN Mitoxantrone DMM39BF MI DTSYQGK DMM39BF MN Multidrug resistance-associated protein 1 (ABCC1) DMM39BF MT DTP DMM39BF MA Substrate DMM39BF RN Multidrug resistance protein 1 (MRP1, ABCC1) mediates resistance to mitoxantrone via glutathione-dependent drug efflux. Mol Pharmacol. 2006 Apr;69(4):1499-505. DMM39BF RU https://doi.org/10.1124/mol.105.017988 DMM39BF DI DMM39BF DMM39BF DN Mitoxantrone DMM39BF MI DTFI42L DMM39BF MN Multidrug resistance-associated protein 2 (ABCC2) DMM39BF MT DTP DMM39BF MA Substrate DMM39BF RN Mammalian drug efflux transporters of the ATP binding cassette (ABC) family in multidrug resistance: A review of the past decade. Cancer Lett. 2016 Jan 1;370(1):153-64. DMM39BF RU http://www.ncbi.nlm.nih.gov/pubmed/26499806 DMM39BF DI DMM39BF DMM39BF DN Mitoxantrone DMM39BF MI DTUGYRD DMM39BF MN P-glycoprotein 1 (ABCB1) DMM39BF MT DTP DMM39BF MA Substrate DMM39BF RN Mammalian drug efflux transporters of the ATP binding cassette (ABC) family in multidrug resistance: A review of the past decade. Cancer Lett. 2016 Jan 1;370(1):153-64. DMM39BF RU http://www.ncbi.nlm.nih.gov/pubmed/26499806 DM473VD DI DM473VD DM473VD DN Mivacurium DM473VD MI TTF4E0J DM473VD MN Neuronal acetylcholine receptor alpha-2 (CHRNA2) DM473VD MT DTT DM473VD MA Antagonist DM473VD RN Pharmacological characteristics of the inhibition of nondepolarizing neuromuscular blocking agents at human adult muscle nicotinic acetylcholine receptor. Anesthesiology. 2009 Jun;110(6):1244-52. DM473VD RU https://pubmed.ncbi.nlm.nih.gov/19417616 DM1FDN8 DI DM1FDN8 DM1FDN8 DN Mizolastine DM1FDN8 MI TTTIBOJ DM1FDN8 MN Histamine H1 receptor (H1R) DM1FDN8 MT DTT DM1FDN8 MA Antagonist DM1FDN8 RN Histamine H1-receptor antagonists inhibit nuclear factor-kappaB and activator protein-1 activities via H1-receptor-dependent and -independent mechanisms. Clin Exp Allergy. 2008 Jun;38(6):947-56. DM1FDN8 RU https://pubmed.ncbi.nlm.nih.gov/18498541 DMW6F0S DI DMW6F0S DMW6F0S DN Mizoribine DMW6F0S MI TTL7C8Q DMW6F0S MN Inosine-5'-monophosphate dehydrogenase 1 (IMPDH1) DMW6F0S MT DTT DMW6F0S MA Inhibitor DMW6F0S RN VX-497: a novel, selective IMPDH inhibitor and immunosuppressive agent. J Pharm Sci. 2001 May;90(5):625-37. DMW6F0S RU https://pubmed.ncbi.nlm.nih.gov/11288107 DM215WE DI DM215WE DM215WE DN MK-1439 DM215WE MI DE4LYSA DM215WE MN Cytochrome P450 3A4 (CYP3A4) DM215WE MT DME DM215WE MA Metabolism DM215WE RN Characterisation of the absorption, distribution, metabolism, excretion and mass balance of doravirine, a non-nucleoside reverse transcriptase inhibitor in humans. Xenobiotica. 2019 Apr;49(4):422-432. DM215WE RU https://www.ncbi.nlm.nih.gov/pubmed/?term=29557716 DM215WE DI DM215WE DM215WE DN MK-1439 DM215WE MI DEIBDNY DM215WE MN Cytochrome P450 3A5 (CYP3A5) DM215WE MT DME DM215WE MA Metabolism DM215WE RN Characterisation of the absorption, distribution, metabolism, excretion and mass balance of doravirine, a non-nucleoside reverse transcriptase inhibitor in humans. Xenobiotica. 2019 Apr;49(4):422-432. DM215WE RU https://www.ncbi.nlm.nih.gov/pubmed/?term=29557716 DM215WE DI DM215WE DM215WE DN MK-1439 DM215WE MI TT84ETX DM215WE MN Human immunodeficiency virus Reverse transcriptase (HIV RT) DM215WE MT DTT DM215WE MA Inhibitor DM215WE RN 2018 FDA drug approvals.Nat Rev Drug Discov. 2019 Feb;18(2):85-89. DM215WE RU https://pubmed.ncbi.nlm.nih.gov/30710142 DMBYNW0 DI DMBYNW0 DMBYNW0 DN MK-3475 DMBYNW0 MI TTNBFWK DMBYNW0 MN Programmed cell death protein 1 (PD-1) DMBYNW0 MT DTT DMBYNW0 RN 2014 FDA drug approvals. Nat Rev Drug Discov. 2015 Feb;14(2):77-81. DMBYNW0 RU https://pubmed.ncbi.nlm.nih.gov/25633781 DMOB58Q DI DMOB58Q DMOB58Q DN MK-8228 DMOB58Q MI TTZHSBO DMOB58Q MN Cytomegalovirus Terminase (CMV TRM) DMOB58Q MT DTT DMOB58Q MA Inhibitor DMOB58Q RN 2017 FDA drug approvals.Nat Rev Drug Discov. 2018 Feb;17(2):81-85. DMOB58Q RU https://pubmed.ncbi.nlm.nih.gov/29348678 DMOB58Q DI DMOB58Q DMOB58Q DN MK-8228 DMOB58Q MI TTOGPL1 DMOB58Q MN Cytomegalovirus Terminase UL56 (CMV TRM1) DMOB58Q MT DTT DMOB58Q MA Inhibitor DMOB58Q RN The novel anticytomegalovirus compound AIC246 (Letermovir) inhibits human cytomegalovirus replication through a specific antiviral mechanism that involves the viral terminase. J Virol. 2011 Oct;85(20):10884-93. DMOB58Q RU https://pubmed.ncbi.nlm.nih.gov/21752907 DMOB58Q DI DMOB58Q DMOB58Q DN MK-8228 DMOB58Q MI DEYGVN4 DMOB58Q MN UDP-glucuronosyltransferase 1A1 (UGT1A1) DMOB58Q MT DME DMOB58Q MA Metabolism DMOB58Q RN Pharmacogenetic analysis of OATP1B1, UGT1A1, and BCRP variants in relation to the pharmacokinetics of letermovir in previously conducted clinical studies. J Clin Pharmacol. 2019 Sep;59(9):1236-1243. DMOB58Q RU https://www.ncbi.nlm.nih.gov/pubmed/?term=31022310 DMP2LZ8 DI DMP2LZ8 DMP2LZ8 DN MLN0002 DMP2LZ8 MI TT7ZMI1 DMP2LZ8 MN Integrin alpha-4/beta-7 (ITGA4/B7) DMP2LZ8 MT DTT DMP2LZ8 MA Modulator DMP2LZ8 RN 2014 FDA drug approvals. Nat Rev Drug Discov. 2015 Feb;14(2):77-81. DMP2LZ8 RU https://pubmed.ncbi.nlm.nih.gov/25633781 DMCMETN DI DMCMETN DMCMETN DN MLN9708 DMCMETN MI DEJGDUW DMCMETN MN Cytochrome P450 1A2 (CYP1A2) DMCMETN MT DME DMCMETN MA Metabolism DMCMETN RN Phase 1/2 trial of ixazomib, cyclophosphamide and dexamethasone in patients with previously untreated symptomatic multiple myeloma. Blood Cancer J. 2018 Jul 30;8(8):70. DMCMETN RU https://www.ncbi.nlm.nih.gov/pubmed/?term=30061664 DMCMETN DI DMCMETN DMCMETN DN MLN9708 DMCMETN MI DEPKLMQ DMCMETN MN Cytochrome P450 2B6 (CYP2B6) DMCMETN MT DME DMCMETN MA Metabolism DMCMETN RN NINLARO- European Medicines Agency - European Union DMCMETN RU https://www.ema.europa.eu/en/documents/product-information/ninlaro-epar-product-information_en.pdf DMCMETN DI DMCMETN DMCMETN DN MLN9708 DMCMETN MI DES5XRU DMCMETN MN Cytochrome P450 2C8 (CYP2C8) DMCMETN MT DME DMCMETN MA Metabolism DMCMETN RN Ninlaro- European Medicines Agency - European Union DMCMETN RU https://www.ema.europa.eu/en/documents/product-information/ninlaro-epar-product-information_en.pdf DMCMETN DI DMCMETN DMCMETN DN MLN9708 DMCMETN MI TTU7ZMG DMCMETN MN Proteasome (PS) DMCMETN MT DTT DMCMETN MA Modulator DMCMETN RN Evaluation of the proteasome inhibitor MLN9708 in preclinical models of human cancer. Cancer Res. 2010 Mar 1;70(5):1970-80. DMCMETN RU https://pubmed.ncbi.nlm.nih.gov/20160034 DMNZWL7 DI DMNZWL7 DMNZWL7 DN Moclobemide DMNZWL7 MI DE5IED8 DMNZWL7 MN Cytochrome P450 2C9 (CYP2C9) DMNZWL7 MT DME DMNZWL7 MA Metabolism DMNZWL7 RN Summary of information on human CYP enzymes: human P450 metabolism data. Drug Metab Rev. 2002 Feb-May;34(1-2):83-448. DMNZWL7 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=11996015 DMNZWL7 DI DMNZWL7 DMNZWL7 DN Moclobemide DMNZWL7 MI DECB0K3 DMNZWL7 MN Cytochrome P450 2D6 (CYP2D6) DMNZWL7 MT DME DMNZWL7 MA Metabolism DMNZWL7 RN Moclobemide, a substrate of CYP2C19 and an inhibitor of CYP2C19, CYP2D6, and CYP1A2: a panel study. Clin Pharmacol Ther. 1995 Jun;57(6):670-7. DMNZWL7 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=7781267 DMNZWL7 DI DMNZWL7 DMNZWL7 DN Moclobemide DMNZWL7 MI DEGTFWK DMNZWL7 MN Mephenytoin 4-hydroxylase (CYP2C19) DMNZWL7 MT DME DMNZWL7 MA Metabolism DMNZWL7 RN Effect of omeprazole on the pharmacokinetics of moclobemide according to the genetic polymorphism of CYP2C19. Clin Pharmacol Ther. 2001 Apr;69(4):266-73. DMNZWL7 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=11309556 DMNZWL7 DI DMNZWL7 DMNZWL7 DN Moclobemide DMNZWL7 MI TT32XQJ DMNZWL7 MN Monoamine oxidase (MAO) DMNZWL7 MT DTT DMNZWL7 MA Inhibitor DMNZWL7 RN Novel monoamine oxidase inhibitors: a patent review (2012 - 2014).Expert Opin Ther Pat. 2015 Jan;25(1):91-110. DMNZWL7 RU https://www.ncbi.nlm.nih.gov/pubmed/25399762 DMNZWL7 DI DMNZWL7 DMNZWL7 DN Moclobemide DMNZWL7 MI TT3WG5C DMNZWL7 MN Monoamine oxidase type A (MAO-A) DMNZWL7 MT DTT DMNZWL7 MA Inhibitor DMNZWL7 RN Efficacy of citalopram and moclobemide in patients with social phobia: some preliminary findings. Hum Psychopharmacol. 2002 Dec;17(8):401-5. DMNZWL7 RU https://pubmed.ncbi.nlm.nih.gov/12457375 DMYILBE DI DMYILBE DMYILBE DN Modafinil DMYILBE MI DE4LYSA DMYILBE MN Cytochrome P450 3A4 (CYP3A4) DMYILBE MT DME DMYILBE MA Metabolism DMYILBE RN Summary of information on human CYP enzymes: human P450 metabolism data. Drug Metab Rev. 2002 Feb-May;34(1-2):83-448. DMYILBE RU https://www.ncbi.nlm.nih.gov/pubmed/?term=11996015 DMYILBE DI DMYILBE DMYILBE DN Modafinil DMYILBE MI TTVBI8W DMYILBE MN Dopamine transporter (DAT) DMYILBE MT DTT DMYILBE MA Modulator DMYILBE RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. DMYILBE RU https://www.fda.gov/ DM26E4B DI DM26E4B DM26E4B DN Moexipril DM26E4B MI TTL69WB DM26E4B MN Angiotensin-converting enzyme (ACE) DM26E4B MT DTT DM26E4B MA Inhibitor DM26E4B RN Moexipril for treatment of primary biliary cirrhosis in patients with an incomplete response to ursodeoxycholic acid. Dig Dis Sci. 2010 Feb;55(2):476-83. DM26E4B RU https://pubmed.ncbi.nlm.nih.gov/19255851 DM26E4B DI DM26E4B DM26E4B DN Moexipril DM26E4B MI DT9G7XN DM26E4B MN Peptide transporter 1 (SLC15A1) DM26E4B MT DTP DM26E4B MA Substrate DM26E4B RN Transport of angiotensin-converting enzyme inhibitors by H+/peptide transporters revisited. J Pharmacol Exp Ther. 2008 Nov;327(2):432-41. DM26E4B RU http://www.ncbi.nlm.nih.gov/pubmed/18713951 DM26E4B DI DM26E4B DM26E4B DN Moexipril DM26E4B MI DT8QKNP DM26E4B MN Peptide transporter 2 (SLC15A2) DM26E4B MT DTP DM26E4B MA Substrate DM26E4B RN Transport of angiotensin-converting enzyme inhibitors by H+/peptide transporters revisited. J Pharmacol Exp Ther. 2008 Nov;327(2):432-41. DM26E4B RU http://www.ncbi.nlm.nih.gov/pubmed/18713951 DMISH0Z DI DMISH0Z DMISH0Z DN Mogamulizumab DMISH0Z MI TT7HQD0 DMISH0Z MN C-C chemokine receptor type 4 (CCR4) DMISH0Z MT DTT DMISH0Z MA Inhibitor DMISH0Z RN Mogamulizumab, a humanized mAb against C-C chemokine receptor 4 for the potential treatment of T-cell lymphomas and asthma. Curr Opin Mol Ther. 2010 Dec;12(6):770-9. DMISH0Z RU https://pubmed.ncbi.nlm.nih.gov/21154168 DMAH70G DI DMAH70G DMAH70G DN Molindone DMAH70G MI TTEX248 DMAH70G MN Dopamine D2 receptor (D2R) DMAH70G MT DTT DMAH70G MA Binder DMAH70G RN Molindone for schizophrenia and severe mental illness. Cochrane Database Syst Rev. 2007 Jan 24;(1):CD002083. DMAH70G RU https://pubmed.ncbi.nlm.nih.gov/17253473 DM9MA8O DI DM9MA8O DM9MA8O DN Molsidomine DM9MA8O MI DE37ABY DM9MA8O MN Phosphodiesterase 5A (PDE5A) DM9MA8O MT DME DM9MA8O MA Metabolism DM9MA8O RN DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. (id: DB09282) DM9MA8O RU https://www.drugbank.ca/drugs/DB09282 DM45OJN DI DM45OJN DM45OJN DN Mometasone DM45OJN MI DE4LYSA DM45OJN MN Cytochrome P450 3A4 (CYP3A4) DM45OJN MT DME DM45OJN MA Metabolism DM45OJN RN Regulation of drug-metabolizing cytochrome P450 enzymes by glucocorticoids. Drug Metab Rev. 2010 Nov;42(4):621-35. DM45OJN RU https://www.ncbi.nlm.nih.gov/pubmed/?term=20482443 DM45OJN DI DM45OJN DM45OJN DN Mometasone DM45OJN MI TTYRL6O DM45OJN MN Glucocorticoid receptor (NR3C1) DM45OJN MT DTT DM45OJN MA Agonist DM45OJN RN Mometasone furoate is a less specific glucocorticoid than fluticasone propionate. Eur Respir J. 2002 Dec;20(6):1386-92. DM45OJN RU https://pubmed.ncbi.nlm.nih.gov/12503693 DMVJS2K DI DMVJS2K DMVJS2K DN Monobenzone DMVJS2K MI TTULVH8 DMVJS2K MN Tyrosinase (TYR) DMVJS2K MT DTT DMVJS2K MA Inhibitor DMVJS2K RN Identification of an Alkylhydroquinone from Rhus succedanea as an Inhibitor of Tyrosinase and Melanogenesis. J Agric Food Chem. 2009 Mar 25;57(6):2200-5. DMVJS2K RU https://pubmed.ncbi.nlm.nih.gov/19159217 DMD157S DI DMD157S DMD157S DN Montelukast DMD157S MI DEJVYAZ DMD157S MN Cytochrome P450 2A6 (CYP2A6) DMD157S MT DME DMD157S MA Metabolism DMD157S RN Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. DMD157S RU https://www.ncbi.nlm.nih.gov/pubmed/?term=19515014 DMD157S DI DMD157S DMD157S DN Montelukast DMD157S MI DES5XRU DMD157S MN Cytochrome P450 2C8 (CYP2C8) DMD157S MT DME DMD157S MA Metabolism DMD157S RN Determinants of cytochrome P450 2C8 substrate binding: structures of complexes with montelukast, troglitazone, felodipine, and 9-cis-retinoic acid. J Biol Chem. 2008 Jun 20;283(25):17227-37. DMD157S RU https://www.ncbi.nlm.nih.gov/pubmed/?term=18413310 DMD157S DI DMD157S DMD157S DN Montelukast DMD157S MI DE5IED8 DMD157S MN Cytochrome P450 2C9 (CYP2C9) DMD157S MT DME DMD157S MA Metabolism DMD157S RN In vitro metabolism of montelukast by cytochrome P450s and UDP-glucuronosyltransferases. Drug Metab Dispos. 2015 Dec;43(12):1905-16. DMD157S RU https://www.ncbi.nlm.nih.gov/pubmed/?term=26374173 DMD157S DI DMD157S DMD157S DN Montelukast DMD157S MI DE4LYSA DMD157S MN Cytochrome P450 3A4 (CYP3A4) DMD157S MT DME DMD157S MA Metabolism DMD157S RN Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. DMD157S RU https://www.ncbi.nlm.nih.gov/pubmed/?term=19515014 DMD157S DI DMD157S DMD157S DN Montelukast DMD157S MI TTGKOY9 DMD157S MN Leukotriene CysLT1 receptor (CYSLTR1) DMD157S MT DTT DMD157S MA Antagonist DMD157S RN Protective potential of montelukast against hepatic ischemia/reperfusion injury in rats. J Surg Res. 2010 Mar;159(1):588-94. DMD157S RU https://pubmed.ncbi.nlm.nih.gov/19515388 DMD157S DI DMD157S DMD157S DN Montelukast DMD157S MI DTE2B1D DMD157S MN Organic anion transporting polypeptide 1A2 (SLCO1A2) DMD157S MT DTP DMD157S MA Substrate DMD157S RN Effect of citrus juice and SLCO2B1 genotype on the pharmacokinetics of montelukast. J Clin Pharmacol. 2011 May;51(5):751-60. DMD157S RU http://www.ncbi.nlm.nih.gov/pubmed/20974993 DMD157S DI DMD157S DMD157S DN Montelukast DMD157S MI DTPFTEQ DMD157S MN Organic anion transporting polypeptide 2B1 (SLCO2B1) DMD157S MT DTP DMD157S MA Substrate DMD157S RN Effects of polymorphisms of the SLCO2B1 transporter gene on the pharmacokinetics of montelukast in humans. J Clin Pharmacol. 2013 Nov;53(11):1186-93. DMD157S RU http://www.ncbi.nlm.nih.gov/pubmed/23970434 DM560Y3 DI DM560Y3 DM560Y3 DN Morantel tartrate DM560Y3 MI TTHDSE2 DM560Y3 MN Bacterial Fumarate reductase flavoprotein (Bact frdA) DM560Y3 MT DTT DM560Y3 MA Inhibitor DM560Y3 RN Fumarate reductase is essential for Helicobacter pylori colonization of the mouse stomach. Microb Pathog. 2000 Nov;29(5):279-87. DM560Y3 RU https://pubmed.ncbi.nlm.nih.gov/11031122 DMOMBJW DI DMOMBJW DMOMBJW DN Moricizine DMOMBJW MI TTZOVE0 DMOMBJW MN Voltage-gated sodium channel alpha Nav1.5 (SCN5A) DMOMBJW MT DTT DMOMBJW MA Blocker DMOMBJW RN From first class to third class: recent upheaval in antiarrhythmic therapy--lessons from clinical trials. Am J Cardiol. 1996 Aug 29;78(4A):28-33. DMOMBJW RU https://pubmed.ncbi.nlm.nih.gov/8780326 DM9UTDE DI DM9UTDE DM9UTDE DN Morniflumate DM9UTDE MI TTK0943 DM9UTDE MN Prostaglandin G/H synthase (COX) DM9UTDE MT DTT DM9UTDE MA Modulator DM9UTDE RN Modulation of arachidonic acid metabolism by orally administered morniflumate in man. Agents Actions. 1991 Jul;33(3-4):233-9. DM9UTDE RU https://pubmed.ncbi.nlm.nih.gov/1659152 DMRMS0L DI DMRMS0L DMRMS0L DN Morphine DMRMS0L MI DES5XRU DMRMS0L MN Cytochrome P450 2C8 (CYP2C8) DMRMS0L MT DME DMRMS0L MA Metabolism DMRMS0L RN In vitro metabolism study of buprenorphine: evidence for new metabolic pathways. Drug Metab Dispos. 2005 May;33(5):689-95. DMRMS0L RU https://www.ncbi.nlm.nih.gov/pubmed/?term=15743975 DMRMS0L DI DMRMS0L DMRMS0L DN Morphine DMRMS0L MI DECB0K3 DMRMS0L MN Cytochrome P450 2D6 (CYP2D6) DMRMS0L MT DME DMRMS0L MA Metabolism DMRMS0L RN Activation of G-proteins by morphine and codeine congeners: insights to the relevance of O- and N-demethylated metabolites at mu- and delta-opioid receptors. J Pharmacol Exp Ther. 2004 Feb;308(2):547-54. DMRMS0L RU https://www.ncbi.nlm.nih.gov/pubmed/?term=14600248 DMRMS0L DI DMRMS0L DMRMS0L DN Morphine DMRMS0L MI DE4LYSA DMRMS0L MN Cytochrome P450 3A4 (CYP3A4) DMRMS0L MT DME DMRMS0L MA Metabolism DMRMS0L RN Modulation of UDP-glucuronosyltransferase 2B7 function by cytochrome P450s in vitro: differential effects of CYP1A2, CYP2C9 and CYP3A4. Biol Pharm Bull. 2005 Oct;28(10):2026-7. DMRMS0L RU https://www.ncbi.nlm.nih.gov/pubmed/?term=16204972 DMRMS0L DI DMRMS0L DMRMS0L DN Morphine DMRMS0L MI DTQ3ZHF DMRMS0L MN Multidrug resistance-associated protein 3 (ABCC3) DMRMS0L MT DTP DMRMS0L MA Substrate DMRMS0L RN Multidrug resistance-associated proteins 3, 4, and 5. Pflugers Arch. 2007 Feb;453(5):661-73. DMRMS0L RU http://www.ncbi.nlm.nih.gov/pubmed/16586096 DMRMS0L DI DMRMS0L DMRMS0L DN Morphine DMRMS0L MI TTKWM86 DMRMS0L MN Opioid receptor mu (MOP) DMRMS0L MT DTT DMRMS0L MA Modulator DMRMS0L RN Antianalgesia: stereoselective action of dextro-morphine over levo-morphine on glia in the mouse spinal cord.J Pharmacol Exp Ther.2005 Sep;314(3):1101-8. DMRMS0L RU https://www.ncbi.nlm.nih.gov/pubmed/15901793 DMRMS0L DI DMRMS0L DMRMS0L DN Morphine DMRMS0L MI DTUGYRD DMRMS0L MN P-glycoprotein 1 (ABCB1) DMRMS0L MT DTP DMRMS0L MA Substrate DMRMS0L RN Genetic variability and clinical efficacy of morphine. Acta Anaesthesiol Scand. 2005 Aug;49(7):902-8. DMRMS0L RU http://www.ncbi.nlm.nih.gov/pubmed/16045647 DMRMS0L DI DMRMS0L DMRMS0L DN Morphine DMRMS0L MI DEYGVN4 DMRMS0L MN UDP-glucuronosyltransferase 1A1 (UGT1A1) DMRMS0L MT DME DMRMS0L MA Metabolism DMRMS0L RN Contribution of UDP-glucuronosyltransferase 1A1 and 1A8 to morphine-6-glucuronidation and its kinetic properties. Drug Metab Dispos. 2008 Apr;36(4):688-94. DMRMS0L RU https://www.ncbi.nlm.nih.gov/pubmed/?term=18187562 DMRMS0L DI DMRMS0L DMRMS0L DN Morphine DMRMS0L MI DEF2WXN DMRMS0L MN UDP-glucuronosyltransferase 1A3 (UGT1A3) DMRMS0L MT DME DMRMS0L MA Metabolism DMRMS0L RN Glucuronidation of amines and other xenobiotics catalyzed by expressed human UDP-glucuronosyltransferase 1A3. Drug Metab Dispos. 1998 Jun;26(6):507-12. DMRMS0L RU https://www.ncbi.nlm.nih.gov/pubmed/?term=9616184 DMRMS0L DI DMRMS0L DMRMS0L DN Morphine DMRMS0L MI DEB3CV1 DMRMS0L MN UDP-glucuronosyltransferase 2B7 (UGT2B7) DMRMS0L MT DME DMRMS0L MA Metabolism DMRMS0L RN Molecular cloning of the baboon UDP-glucuronosyltransferase 2B gene family and their activity in conjugating morphine. Drug Metab Dispos. 2010 Apr;38(4):545-53. DMRMS0L RU https://www.ncbi.nlm.nih.gov/pubmed/?term=20071451 DMEJKRF DI DMEJKRF DMEJKRF DN Motexafin gadolinium DMEJKRF MI TTLPJWH DMEJKRF MN Thioredoxin reductase (PRDX5) DMEJKRF MT DTT DMEJKRF MA Modulator DMEJKRF RN Mechanism of inhibition of ribonucleotide reductase with motexafin gadolinium (MGd). Biochem Biophys Res Commun. 2009 Feb 13;379(3):775-9. DMEJKRF RU https://pubmed.ncbi.nlm.nih.gov/19121624 DMYKUNR DI DMYKUNR DMYKUNR DN Moxalactam Disodium DMYKUNR MI TT85JMW DMYKUNR MN Bacterial Penicillin binding protein 3 (Bact mrcA) DMYKUNR MT DTT DMYKUNR MA Modulator DMYKUNR RN Moxalactam (6059-S), a new 1-oxa-beta-lactam: binding affinity for penicillin-binding proteins of Escherichia coli K-12. DMYKUNR RU https://www.ncbi.nlm.nih.gov/pmc/articles/PMC283783 DMN63DZ DI DMN63DZ DMN63DZ DN Moxetumomab pasudotox DMN63DZ MI TTM6QSK DMN63DZ MN B-cell receptor CD22 (CD22) DMN63DZ MT DTT DMN63DZ MA Modulator DMN63DZ RN Antibody fusion proteins: anti-CD22 recombinant immunotoxin moxetumomab pasudotox. Clin Cancer Res. 2011 Oct 15;17(20):6398-405. DMN63DZ RU https://pubmed.ncbi.nlm.nih.gov/22003067 DMYGHX5 DI DMYGHX5 DMYGHX5 DN Moxidectin DMYGHX5 MI TTNJYV2 DMYGHX5 MN Gamma-aminobutyric acid receptor (GAR) DMYGHX5 MT DTT DMYGHX5 MA Modulator DMYGHX5 RN 2018 FDA drug approvals.Nat Rev Drug Discov. 2019 Feb;18(2):85-89. DMYGHX5 RU https://pubmed.ncbi.nlm.nih.gov/30710142 DMYGHX5 DI DMYGHX5 DMYGHX5 DN Moxidectin DMYGHX5 MI TTSNVHO DMYGHX5 MN Onchocerca Glutamate-gated chloride channel (Onchoc GluCl) DMYGHX5 MT DTT DMYGHX5 MA Modulator DMYGHX5 RN 2018 FDA drug approvals.Nat Rev Drug Discov. 2019 Feb;18(2):85-89. DMYGHX5 RU https://pubmed.ncbi.nlm.nih.gov/30710142 DMU8V4S DI DMU8V4S DMU8V4S DN Moxifloxacin DMU8V4S MI TTN6J5F DMU8V4S MN Bacterial DNA gyrase (Bact gyrase) DMU8V4S MT DTT DMU8V4S MA Modulator DMU8V4S RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. DMU8V4S RU https://www.fda.gov/ DMU8V4S DI DMU8V4S DMU8V4S DN Moxifloxacin DMU8V4S MI TTIXTO3 DMU8V4S MN Staphylococcus Topoisomerase IV (Stap-coc parC) DMU8V4S MT DTT DMU8V4S MA Modulator DMU8V4S RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. DMU8V4S RU https://www.fda.gov/ DMFCLYW DI DMFCLYW DMFCLYW DN Moxisylyte DMFCLYW MI TT34BHT DMFCLYW MN Adrenergic receptor alpha-1D (ADRA1D) DMFCLYW MT DTT DMFCLYW MA Modulator DMFCLYW RN Pharmacokinetics of moxisylyte in healthy volunteers after intracavernous injection of increasing doses. Eur J Clin Pharmacol. 1996;49(5):411-5. DMFCLYW RU https://pubmed.ncbi.nlm.nih.gov/8866639 DMGFB0E DI DMGFB0E DMGFB0E DN MOXONIDINE DMGFB0E MI TTWG9A4 DMGFB0E MN Adrenergic receptor alpha-2A (ADRA2A) DMGFB0E MT DTT DMGFB0E MA Inhibitor DMGFB0E RN Synthesis and pharmacologic evaluation of 2-endo-amino-3-exo-isopropylbicyclo[2.2.1]heptane: a potent imidazoline1 receptor specific agent. J Med Chem. 1996 Mar 15;39(6):1193-5. DMGFB0E RU https://pubmed.ncbi.nlm.nih.gov/8632424 DMGFB0E DI DMGFB0E DMGFB0E DN MOXONIDINE DMGFB0E MI TTWM4TY DMGFB0E MN Adrenergic receptor alpha-2B (ADRA2B) DMGFB0E MT DTT DMGFB0E MA Inhibitor DMGFB0E RN Synthesis and pharmacologic evaluation of 2-endo-amino-3-exo-isopropylbicyclo[2.2.1]heptane: a potent imidazoline1 receptor specific agent. J Med Chem. 1996 Mar 15;39(6):1193-5. DMGFB0E RU https://pubmed.ncbi.nlm.nih.gov/8632424 DMGFB0E DI DMGFB0E DMGFB0E DN MOXONIDINE DMGFB0E MI TT2NUT5 DMGFB0E MN Adrenergic receptor alpha-2C (ADRA2C) DMGFB0E MT DTT DMGFB0E MA Inhibitor DMGFB0E RN Synthesis and pharmacologic evaluation of 2-endo-amino-3-exo-isopropylbicyclo[2.2.1]heptane: a potent imidazoline1 receptor specific agent. J Med Chem. 1996 Mar 15;39(6):1193-5. DMGFB0E RU https://pubmed.ncbi.nlm.nih.gov/8632424 DMZ905C DI DMZ905C DMZ905C DN Mozavaptan DMZ905C MI TTPFZJ1 DMZ905C MN Vasopressin V1 receptor (V1R) DMZ905C MT DTT DMZ905C MA Antagonist DMZ905C RN Vasopressin (ADH). Nippon Rinsho. 1992 Dec;50(12):2893-900. DMZ905C RU https://pubmed.ncbi.nlm.nih.gov/1337114 DMZ905C DI DMZ905C DMZ905C DN Mozavaptan DMZ905C MI TT4TFGN DMZ905C MN Vasopressin V1a receptor (V1AR) DMZ905C MT DTT DMZ905C MA Inhibitor DMZ905C RN Nonpeptide vasopressin antagonists: a new group of hormone blockers entering the scene. Exp Clin Endocrinol Diabetes. 1999;107(3):157-65. DMZ905C RU https://pubmed.ncbi.nlm.nih.gov/10376439 DMZ905C DI DMZ905C DMZ905C DN Mozavaptan DMZ905C MI TTL9MHW DMZ905C MN Vasopressin V1b receptor (V1BR) DMZ905C MT DTT DMZ905C MA Inhibitor DMZ905C RN New analgesic drugs derived from phencyclidine. J Med Chem. 1981 May;24(5):496-9. DMZ905C RU https://pubmed.ncbi.nlm.nih.gov/7241506 DMZ905C DI DMZ905C DMZ905C DN Mozavaptan DMZ905C MI TTK8R02 DMZ905C MN Vasopressin V2 receptor (V2R) DMZ905C MT DTT DMZ905C MA Inhibitor DMZ905C RN Nonpeptide vasopressin receptor antagonists: development of selective and orally active V1a, V2 and V1b receptor ligands. Prog Brain Res. 2002;139:197-210. DMZ905C RU https://pubmed.ncbi.nlm.nih.gov/12436936 DMWX683 DI DMWX683 DMWX683 DN Mupirocin DMWX683 MI TT6KYJ5 DMWX683 MN Bacterial Isoleucyl-tRNA synthetase (Bact ileS) DMWX683 MT DTT DMWX683 MA Modulator DMWX683 RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. DMWX683 RU https://www.fda.gov/ DM8ANCF DI DM8ANCF DM8ANCF DN Muromonab DM8ANCF MI TTZAT79 DM8ANCF MN T-cell surface glycoprotein CD3 epsilon (CD3E) DM8ANCF MT DTT DM8ANCF MA Binder DM8ANCF RN Basiliximab: a review of its use as induction therapy in renal transplantation. Drugs. 2003;63(24):2803-35. DM8ANCF RU https://pubmed.ncbi.nlm.nih.gov/14664658 DMPQAGE DI DMPQAGE DMPQAGE DN Mycophenolate mofetil DMPQAGE MI DTI7UX6 DMPQAGE MN Breast cancer resistance protein (ABCG2) DMPQAGE MT DTP DMPQAGE MA Substrate DMPQAGE RN Influence of drug transporters and UGT polymorphisms on pharmacokinetics of phenolic glucuronide metabolite of mycophenolic acid in Japanese renal transplant recipients. Ther Drug Monit. 2008 Oct;30(5):559-64. DMPQAGE RU http://www.ncbi.nlm.nih.gov/pubmed/18695635 DMPQAGE DI DMPQAGE DMPQAGE DN Mycophenolate mofetil DMPQAGE MI DES5XRU DMPQAGE MN Cytochrome P450 2C8 (CYP2C8) DMPQAGE MT DME DMPQAGE MA Metabolism DMPQAGE RN PharmGKB summary: mycophenolic acid pathway. Pharmacogenet Genomics. 2014 Jan;24(1):73-9. DMPQAGE RU https://www.ncbi.nlm.nih.gov/pubmed/?term=24220207 DMPQAGE DI DMPQAGE DMPQAGE DN Mycophenolate mofetil DMPQAGE MI DE4LYSA DMPQAGE MN Cytochrome P450 3A4 (CYP3A4) DMPQAGE MT DME DMPQAGE MA Metabolism DMPQAGE RN PharmGKB summary: mycophenolic acid pathway. Pharmacogenet Genomics. 2014 Jan;24(1):73-9. DMPQAGE RU https://www.ncbi.nlm.nih.gov/pubmed/?term=24220207 DMPQAGE DI DMPQAGE DMPQAGE DN Mycophenolate mofetil DMPQAGE MI DEIBDNY DMPQAGE MN Cytochrome P450 3A5 (CYP3A5) DMPQAGE MT DME DMPQAGE MA Metabolism DMPQAGE RN PharmGKB summary: mycophenolic acid pathway. Pharmacogenet Genomics. 2014 Jan;24(1):73-9. DMPQAGE RU https://www.ncbi.nlm.nih.gov/pubmed/?term=24220207 DMPQAGE DI DMPQAGE DMPQAGE DN Mycophenolate mofetil DMPQAGE MI TTTB4UP DMPQAGE MN Inosine-5'-monophosphate dehydrogenase 2 (IMPDH2) DMPQAGE MT DTT DMPQAGE MA Inhibitor DMPQAGE RN Clinical pipeline report, company report or official report of Roche (2009). DMPQAGE RU http://www.roche.com/research_and_development/pipeline/roche_pharma_pipeline.htm DMPQAGE DI DMPQAGE DMPQAGE DN Mycophenolate mofetil DMPQAGE MI DTFI42L DMPQAGE MN Multidrug resistance-associated protein 2 (ABCC2) DMPQAGE MT DTP DMPQAGE MA Substrate DMPQAGE RN Influence of SLCO1B1, 1B3, 2B1 and ABCC2 genetic polymorphisms on mycophenolic acid pharmacokinetics in Japanese renal transplant recipients. Eur J Clin Pharmacol. 2007 Dec;63(12):1161-9. DMPQAGE RU http://www.ncbi.nlm.nih.gov/pubmed/17906856 DMPQAGE DI DMPQAGE DMPQAGE DN Mycophenolate mofetil DMPQAGE MI DT3D8F0 DMPQAGE MN Organic anion transporting polypeptide 1B1 (SLCO1B1) DMPQAGE MT DTP DMPQAGE MA Substrate DMPQAGE RN Influence of SLCO1B1, 1B3, 2B1 and ABCC2 genetic polymorphisms on mycophenolic acid pharmacokinetics in Japanese renal transplant recipients. Eur J Clin Pharmacol. 2007 Dec;63(12):1161-9. DMPQAGE RU http://www.ncbi.nlm.nih.gov/pubmed/17906856 DMPQAGE DI DMPQAGE DMPQAGE DN Mycophenolate mofetil DMPQAGE MI DT9C1TS DMPQAGE MN Organic anion transporting polypeptide 1B3 (SLCO1B3) DMPQAGE MT DTP DMPQAGE MA Substrate DMPQAGE RN Influence of SLCO1B1, 1B3, 2B1 and ABCC2 genetic polymorphisms on mycophenolic acid pharmacokinetics in Japanese renal transplant recipients. Eur J Clin Pharmacol. 2007 Dec;63(12):1161-9. DMPQAGE RU http://www.ncbi.nlm.nih.gov/pubmed/17906856 DMPQAGE DI DMPQAGE DMPQAGE DN Mycophenolate mofetil DMPQAGE MI DTUGYRD DMPQAGE MN P-glycoprotein 1 (ABCB1) DMPQAGE MT DTP DMPQAGE MA Substrate DMPQAGE RN Influence of drug transporters and UGT polymorphisms on pharmacokinetics of phenolic glucuronide metabolite of mycophenolic acid in Japanese renal transplant recipients. Ther Drug Monit. 2008 Oct;30(5):559-64. DMPQAGE RU http://www.ncbi.nlm.nih.gov/pubmed/18695635 DMPQAGE DI DMPQAGE DMPQAGE DN Mycophenolate mofetil DMPQAGE MI TT1ZAVI DMPQAGE MN Prostaglandin E2 receptor EP2 (PTGER2) DMPQAGE MT DTT DMPQAGE MA Modulator DMPQAGE RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 341). DMPQAGE RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=341 DMPQAGE DI DMPQAGE DMPQAGE DN Mycophenolate mofetil DMPQAGE MI DEYGVN4 DMPQAGE MN UDP-glucuronosyltransferase 1A1 (UGT1A1) DMPQAGE MT DME DMPQAGE MA Metabolism DMPQAGE RN Characterization of rat intestinal microsomal UDP-glucuronosyltransferase activity toward mycophenolic acid. Drug Metab Dispos. 2006 Sep;34(9):1632-9. DMPQAGE RU https://www.ncbi.nlm.nih.gov/pubmed/?term=16790558 DMPQAGE DI DMPQAGE DMPQAGE DN Mycophenolate mofetil DMPQAGE MI DEL5N6Y DMPQAGE MN UDP-glucuronosyltransferase 1A10 (UGT1A10) DMPQAGE MT DME DMPQAGE MA Metabolism DMPQAGE RN [Pharmacology of mycophenolate mofetil: recent data and clinical consequences]. Nephrologie. 2001;22(7):331-7. DMPQAGE RU https://www.ncbi.nlm.nih.gov/pubmed/?term=11817210 DMPQAGE DI DMPQAGE DMPQAGE DN Mycophenolate mofetil DMPQAGE MI DESD26P DMPQAGE MN UDP-glucuronosyltransferase 1A6 (UGT1A6) DMPQAGE MT DME DMPQAGE MA Metabolism DMPQAGE RN Characterization of rat intestinal microsomal UDP-glucuronosyltransferase activity toward mycophenolic acid. Drug Metab Dispos. 2006 Sep;34(9):1632-9. DMPQAGE RU https://www.ncbi.nlm.nih.gov/pubmed/?term=16790558 DMPQAGE DI DMPQAGE DMPQAGE DN Mycophenolate mofetil DMPQAGE MI DE85D2P DMPQAGE MN UDP-glucuronosyltransferase 1A9 (UGT1A9) DMPQAGE MT DME DMPQAGE MA Metabolism DMPQAGE RN The evolution of population pharmacokinetic models to describe the enterohepatic recycling of mycophenolic acid in solid organ transplantation and autoimmune disease. Clin Pharmacokinet. 2011 Jan;50(1):1-24. DMPQAGE RU https://www.ncbi.nlm.nih.gov/pubmed/?term=21142265 DMPQAGE DI DMPQAGE DMPQAGE DN Mycophenolate mofetil DMPQAGE MI DEB3CV1 DMPQAGE MN UDP-glucuronosyltransferase 2B7 (UGT2B7) DMPQAGE MT DME DMPQAGE MA Metabolism DMPQAGE RN PharmGKB summary: mycophenolic acid pathway. Pharmacogenet Genomics. 2014 Jan;24(1):73-9. DMPQAGE RU https://www.ncbi.nlm.nih.gov/pubmed/?term=24220207 DMYTN18 DI DMYTN18 DMYTN18 DN Mycophenolic acid DMYTN18 MI DTFI42L DMYTN18 MN Multidrug resistance-associated protein 2 (ABCC2) DMYTN18 MT DTP DMYTN18 MA Substrate DMYTN18 RN C-440T/T-331C polymorphisms in the UGT1A9 gene affect the pharmacokinetics of mycophenolic acid in kidney transplantation. Pharmacogenomics. 2007 Sep;8(9):1127-41. DMYTN18 RU http://www.ncbi.nlm.nih.gov/pubmed/17924828 DMYTN18 DI DMYTN18 DMYTN18 DN Mycophenolic acid DMYTN18 MI DTQ23VB DMYTN18 MN Organic anion transporter 1 (SLC22A6) DMYTN18 MT DTP DMYTN18 MA Substrate DMYTN18 RN Interaction and transport characteristics of mycophenolic acid and its glucuronide via human organic anion transporters hOAT1 and hOAT3. Biochem Pharmacol. 2007 Jun 30;74(1):161-8. DMYTN18 RU http://www.ncbi.nlm.nih.gov/pubmed/17462604 DMRBMAU DI DMRBMAU DMRBMAU DN Mycophenolic acid DMRBMAU MI DE85D2P DMRBMAU MN UDP-glucuronosyltransferase 1A9 (UGT1A9) DMRBMAU MT DME DMRBMAU MA Metabolism DMRBMAU RN Diabetes mellitus reduces activity of human UDP-glucuronosyltransferase 2B7 in liver and kidney leading to decreased formation of mycophenolic acid acyl-glucuronide metabolite. Drug Metab Dispos. 2011 Mar;39(3):448-55. DMRBMAU RU https://www.ncbi.nlm.nih.gov/pubmed/?term=21123165 DMRBMAU DI DMRBMAU DMRBMAU DN Mycophenolic acid DMRBMAU MI DEB3CV1 DMRBMAU MN UDP-glucuronosyltransferase 2B7 (UGT2B7) DMRBMAU MT DME DMRBMAU MA Metabolism DMRBMAU RN Diabetes mellitus reduces activity of human UDP-glucuronosyltransferase 2B7 in liver and kidney leading to decreased formation of mycophenolic acid acyl-glucuronide metabolite. Drug Metab Dispos. 2011 Mar;39(3):448-55. DMRBMAU RU https://www.ncbi.nlm.nih.gov/pubmed/?term=21123165 DMSOAJ2 DI DMSOAJ2 DMSOAJ2 DN N-0923 DMSOAJ2 MI TTEX248 DMSOAJ2 MN Dopamine D2 receptor (D2R) DMSOAJ2 MT DTT DMSOAJ2 MA Agonist DMSOAJ2 RN Drugs used to treat Parkinson's disease, present status and future directions. CNS Neurol Disord Drug Targets. 2008 Oct;7(4):321-42. DMSOAJ2 RU https://pubmed.ncbi.nlm.nih.gov/18991661 DMHJVOL DI DMHJVOL DMHJVOL DN Nabi-HB DMHJVOL MI TT6KSF7 DMHJVOL MN Hepatitis B virus Large envelope protein (HBV S) DMHJVOL MT DTT DMHJVOL MA Modulator DMHJVOL RN Hepatitis B Immune Globulin (Human) Nabi-HB . US Food and Drug Administration report. DMHJVOL RU http://www.fda.gov/downloads/BiologicsBloodVaccines/BloodBloodProducts/ApprovedProducts/LicensedProductsBLAs/FractionatedPlasmaProducts/ucm117658.pdf DMVRYT2 DI DMVRYT2 DMVRYT2 DN Nabilone DMVRYT2 MI TT6OEDT DMVRYT2 MN Cannabinoid receptor 1 (CB1) DMVRYT2 MT DTT DMVRYT2 MA Inhibitor DMVRYT2 RN Novel 1',1'-chain substituted hexahydrocannabinols: 9-hydroxy-3-(1-hexyl-cyclobut-1-yl)-hexahydrocannabinol (AM2389) a highly potent cannabinoid r... J Med Chem. 2010 Oct 14;53(19):6996-7010. DMVRYT2 RU https://pubmed.ncbi.nlm.nih.gov/20925434 DMVRYT2 DI DMVRYT2 DMVRYT2 DN Nabilone DMVRYT2 MI TTMSFAW DMVRYT2 MN Cannabinoid receptor 2 (CB2) DMVRYT2 MT DTT DMVRYT2 MA Inhibitor DMVRYT2 RN Novel 1',1'-chain substituted hexahydrocannabinols: 9-hydroxy-3-(1-hexyl-cyclobut-1-yl)-hexahydrocannabinol (AM2389) a highly potent cannabinoid r... J Med Chem. 2010 Oct 14;53(19):6996-7010. DMVRYT2 RU https://pubmed.ncbi.nlm.nih.gov/20925434 DMAT2XH DI DMAT2XH DMAT2XH DN Nabumetone DMAT2XH MI DE7P2FB DMAT2XH MN Aldo-keto reductase 1C1 (AKR1C1) DMAT2XH MT DME DMAT2XH MA Metabolism DMAT2XH RN Reductive metabolism of nabumetone by human liver microsomal and cytosolic fractions: exploratory prediction using inhibitors and substrates as marker probes. Eur J Drug Metab Pharmacokinet. 2015 Jun;40(2):127-35. DMAT2XH RU https://www.ncbi.nlm.nih.gov/pubmed/?term=24659525 DMAT2XH DI DMAT2XH DMAT2XH DN Nabumetone DMAT2XH MI DEAJN47 DMAT2XH MN Aldo-keto reductase 1C4 (AKR1C4) DMAT2XH MT DME DMAT2XH MA Metabolism DMAT2XH RN Reductive metabolism of nabumetone by human liver microsomal and cytosolic fractions: exploratory prediction using inhibitors and substrates as marker probes. Eur J Drug Metab Pharmacokinet. 2015 Jun;40(2):127-35. DMAT2XH RU https://www.ncbi.nlm.nih.gov/pubmed/?term=24659525 DMAT2XH DI DMAT2XH DMAT2XH DN Nabumetone DMAT2XH MI DEZDRQO DMAT2XH MN Corticosteroid 11-beta-dehydrogenase 1 (HSD11B1) DMAT2XH MT DME DMAT2XH MA Metabolism DMAT2XH RN Reductive metabolism of nabumetone by human liver microsomal and cytosolic fractions: exploratory prediction using inhibitors and substrates as marker probes. Eur J Drug Metab Pharmacokinet. 2015 Jun;40(2):127-35. DMAT2XH RU https://www.ncbi.nlm.nih.gov/pubmed/?term=24659525 DMAT2XH DI DMAT2XH DMAT2XH DN Nabumetone DMAT2XH MI DEJGDUW DMAT2XH MN Cytochrome P450 1A2 (CYP1A2) DMAT2XH MT DME DMAT2XH MA Metabolism DMAT2XH RN A predominate role of CYP1A2 for the metabolism of nabumetone to the active metabolite, 6-methoxy-2-naphthylacetic acid, in human liver microsomes. Drug Metab Dispos. 2009 May;37(5):1017-24. DMAT2XH RU https://www.ncbi.nlm.nih.gov/pubmed/?term=19204080 DMAT2XH DI DMAT2XH DMAT2XH DN Nabumetone DMAT2XH MI DE5IED8 DMAT2XH MN Cytochrome P450 2C9 (CYP2C9) DMAT2XH MT DME DMAT2XH MA Metabolism DMAT2XH RN In vitro characterization of the cytochrome P450 isoforms involved in the metabolism of 6-methoxy-2-napthylacetic acid, an active metabolite of the prodrug nabumetone. Biol Pharm Bull. 2011;34(5):734-9. DMAT2XH RU https://www.ncbi.nlm.nih.gov/pubmed/?term=21532165 DMAT2XH DI DMAT2XH DMAT2XH DN Nabumetone DMAT2XH MI TTVKILB DMAT2XH MN Prostaglandin G/H synthase 2 (COX-2) DMAT2XH MT DTT DMAT2XH MA Inhibitor DMAT2XH RN Renal effects of nabumetone, a COX-2 antagonist: impairment of function in isolated perfused rat kidneys contrasts with preserved renal function in vivo. Exp Nephrol. 2001;9(6):387-96. DMAT2XH RU https://pubmed.ncbi.nlm.nih.gov/11701998 DM1XBWR DI DM1XBWR DM1XBWR DN N-acetyl-D-glucosamine DM1XBWR MI TTDM6HZ DM1XBWR MN Alpha-N-acetylglucosaminidase (NAGLU) DM1XBWR MT DTT DM1XBWR MA Activator DM1XBWR RN Development of bFGF-Chitosan Matrices and Their Interactions with Human Dermal Fibroblast Cells. J Biomater Sci Polym Ed. 2009;20(10):1335-51. DM1XBWR RU https://pubmed.ncbi.nlm.nih.gov/19622275 DM1XBWR DI DM1XBWR DM1XBWR DN N-acetyl-D-glucosamine DM1XBWR MI DEROYHE DM1XBWR MN N-acetyl-D-glucosamine 2-epimerase (AGE) DM1XBWR MT DME DM1XBWR MA Metabolism DM1XBWR RN Production of N-acetyl-d-neuraminic acid by whole cells expressing Bacteroides thetaiotaomicron N-acetyl-d-glucosamine 2-epimerase and Escherichia coli N-acetyl-d-neuraminic acid aldolase. J Agric Food Chem. 2019 Jun 5;67(22):6285-6291. DM1XBWR RU https://www.ncbi.nlm.nih.gov/pubmed/?term=31117501 DM5NM6E DI DM5NM6E DM5NM6E DN NADH DM5NM6E MI DEE5M8O DM5NM6E MN Alcohol dehydrogenase class-I alpha (ADH1A) DM5NM6E MT DME DM5NM6E MA Metabolism DM5NM6E RN Conformational changes and catalysis by alcohol dehydrogenase. Arch Biochem Biophys. 2010 Jan 1;493(1):3-12. DM5NM6E RU https://www.ncbi.nlm.nih.gov/pubmed/?term=19583966 DM5NM6E DI DM5NM6E DM5NM6E DN NADH DM5NM6E MI DEEN9RD DM5NM6E MN Alcohol dehydrogenase class-I beta (ADH1B) DM5NM6E MT DME DM5NM6E MA Metabolism DM5NM6E RN Conformational changes and catalysis by alcohol dehydrogenase. Arch Biochem Biophys. 2010 Jan 1;493(1):3-12. DM5NM6E RU https://www.ncbi.nlm.nih.gov/pubmed/?term=19583966 DM5NM6E DI DM5NM6E DM5NM6E DN NADH DM5NM6E MI DEIOH6A DM5NM6E MN Alcohol dehydrogenase class-III (ADH5) DM5NM6E MT DME DM5NM6E MA Metabolism DM5NM6E RN Conformational changes and catalysis by alcohol dehydrogenase. Arch Biochem Biophys. 2010 Jan 1;493(1):3-12. DM5NM6E RU https://www.ncbi.nlm.nih.gov/pubmed/?term=19583966 DM5NM6E DI DM5NM6E DM5NM6E DN NADH DM5NM6E MI DE017IC DM5NM6E MN Alcohol dehydrogenase class-V (ADH6) DM5NM6E MT DME DM5NM6E MA Metabolism DM5NM6E RN Conformational changes and catalysis by alcohol dehydrogenase. Arch Biochem Biophys. 2010 Jan 1;493(1):3-12. DM5NM6E RU https://www.ncbi.nlm.nih.gov/pubmed/?term=19583966 DM5NM6E DI DM5NM6E DM5NM6E DN NADH DM5NM6E MI DED2FW3 DM5NM6E MN Aldo-keto reductase 1A1 (AKR1A1) DM5NM6E MT DME DM5NM6E MA Metabolism DM5NM6E RN Conformational changes and catalysis by alcohol dehydrogenase. Arch Biochem Biophys. 2010 Jan 1;493(1):3-12. DM5NM6E RU https://www.ncbi.nlm.nih.gov/pubmed/?term=19583966 DM5NM6E DI DM5NM6E DM5NM6E DN NADH DM5NM6E MI DE4A3BL DM5NM6E MN Diaphorase-1 (CYB5R3) DM5NM6E MT DME DM5NM6E MA Metabolism DM5NM6E RN Expression of a novel P275L variant of NADH:cytochrome b5 reductase gives functional insight into the conserved motif important for pyridine nucleotide binding. Arch Biochem Biophys. 2006 Mar 1;447(1):59-67. DM5NM6E RU https://www.ncbi.nlm.nih.gov/pubmed/?term=16469290 DM5NM6E DI DM5NM6E DM5NM6E DN NADH DM5NM6E MI DEZMAHX DM5NM6E MN Gastric alcohol dehydrogenase (ADH7) DM5NM6E MT DME DM5NM6E MA Metabolism DM5NM6E RN Conformational changes and catalysis by alcohol dehydrogenase. Arch Biochem Biophys. 2010 Jan 1;493(1):3-12. DM5NM6E RU https://www.ncbi.nlm.nih.gov/pubmed/?term=19583966 DM5NM6E DI DM5NM6E DM5NM6E DN NADH DM5NM6E MI DEGSPC9 DM5NM6E MN Hydroxyacyl-CoA dehydrogenase 2 (HSD17B10) DM5NM6E MT DME DM5NM6E MA Metabolism DM5NM6E RN A human brain L-3-hydroxyacyl-coenzyme A dehydrogenase is identical to an amyloid beta-peptide-binding protein involved in Alzheimer's disease. J Biol Chem. 1998 Apr 24;273(17):10741-6. DM5NM6E RU https://www.ncbi.nlm.nih.gov/pubmed/?term=9553139 DM5NM6E DI DM5NM6E DM5NM6E DN NADH DM5NM6E MI TTTJF7V DM5NM6E MN NADH dehydrogenase (MT-ND3) DM5NM6E MT DTT DM5NM6E MA Binder DM5NM6E RN Mechanism of cadmium-decreased glucuronidation in the rat. Biochem Pharmacol. 1992 Dec 1;44(11):2139-47. DM5NM6E RU https://pubmed.ncbi.nlm.nih.gov/1472079 DM5NM6E DI DM5NM6E DM5NM6E DN NADH DM5NM6E MI DESICUZ DM5NM6E MN Retinol dehydrogenase 13 (RDH13) DM5NM6E MT DME DM5NM6E MA Metabolism DM5NM6E RN Human retinol dehydrogenase 13 (RDH13) is a mitochondrial short-chain dehydrogenase/reductase with a retinaldehyde reductase activity. FEBS J. 2008 Jan;275(1):138-47. DM5NM6E RU https://www.ncbi.nlm.nih.gov/pubmed/?term=18039331 DM5NM6E DI DM5NM6E DM5NM6E DN NADH DM5NM6E MI DEWDJU4 DM5NM6E MN Retinol dehydrogenase 14 (RDH14) DM5NM6E MT DME DM5NM6E MA Metabolism DM5NM6E RN Human pancreas protein 2 (PAN2) has a retinal reductase activity and is ubiquitously expressed in human tissues. FEBS Lett. 2002 Nov 20;531(3):489-93. DM5NM6E RU https://www.ncbi.nlm.nih.gov/pubmed/?term=12435598 DMW6GVL DI DMW6GVL DMW6GVL DN Nadolol DMW6GVL MI TTR6W5O DMW6GVL MN Adrenergic receptor beta-1 (ADRB1) DMW6GVL MT DTT DMW6GVL MA Modulator DMW6GVL RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. DMW6GVL RU https://www.fda.gov/ DMW6GVL DI DMW6GVL DMW6GVL DN Nadolol DMW6GVL MI DTE2B1D DMW6GVL MN Organic anion transporting polypeptide 1A2 (SLCO1A2) DMW6GVL MT DTP DMW6GVL MA Substrate DMW6GVL RN Involvement of influx and efflux transport systems in gastrointestinal absorption of celiprolol. J Pharm Sci. 2009 Jul;98(7):2529-39. DMW6GVL RU http://www.ncbi.nlm.nih.gov/pubmed/19067419 DMW6GVL DI DMW6GVL DMW6GVL DN Nadolol DMW6GVL MI DTUGYRD DMW6GVL MN P-glycoprotein 1 (ABCB1) DMW6GVL MT DTP DMW6GVL MA Substrate DMW6GVL RN Tarascon Pocket Pharmacopoeia 2018 Classic Shirt-Pocket Edition. DMW6GVL RU https://books.google.com/books?id=0gBRDwAAQBAJ&pg=PP37&lpg=PP37&dq=Methylergonovine+transporter+uptake+efflex&source=bl&ots=cUTe_ppsmZ&sig=ACfU3U3E_YqrDg0CNEuj8K-7lci47HAnrg&hl=zh-CN&sa=X&ved=2ahUKEwjnj-Dk7d7iAhUsK6YKHd5DBDkQ6AEwEnoECAgQAQ#v=onepage&q&f=false DMBNKST DI DMBNKST DMBNKST DN Nadroparin calcium DMBNKST MI TTCIHJA DMBNKST MN Coagulation factor Xa (F10) DMBNKST MT DTT DMBNKST MA Modulator DMBNKST RN Serum zinc concentrations: contamination from laboratory equipment. JPEN J Parenter Enteral Nutr. 1979 May-Jun;3(3):179-81. DMBNKST RU https://pubmed.ncbi.nlm.nih.gov/113585 DMU1XOD DI DMU1XOD DMU1XOD DN Nafamostat DMU1XOD MI TTEMV5X DMU1XOD MN Serine protease unspecific (SP) DMU1XOD MT DTT DMU1XOD MA Inhibitor DMU1XOD RN Tryptase-positive mast cells correlate with angiogenesis in early breast cancer patients. Int J Oncol. 2009 Jul;35(1):115-20. DMU1XOD RU https://pubmed.ncbi.nlm.nih.gov/19513558 DMU1XOD DI DMU1XOD DMU1XOD DN Nafamostat DMU1XOD MI TTF8CQI DMU1XOD MN Tumor necrosis factor (TNF) DMU1XOD MT DTT DMU1XOD RN Clinical pipeline report, company report or official report of AstraZeneca (2009). DMU1XOD RU http://www.astrazeneca.com/_mshost3690701/content/resources/media/investors/AZN-Q2-2009/AZN-Q2-2009-Pipeline.pdf DMAHEFY DI DMAHEFY DMAHEFY DN Nafarelin DMAHEFY MI TT8R70G DMAHEFY MN Gonadotropin-releasing hormone receptor (GNRHR) DMAHEFY MT DTT DMAHEFY MA Agonist DMAHEFY RN Reversible downregulation of endocrine and germinative testicular function (hormonal castration) in the dog with the GnRH-agonist azagly-nafarelin ... Theriogenology. 2009 Apr 15;71(7):1037-45. DMAHEFY RU https://pubmed.ncbi.nlm.nih.gov/19233456 DMN9RPO DI DMN9RPO DMN9RPO DN Nafcillin DMN9RPO MI TTJP4SM DMN9RPO MN Bacterial Penicillin binding protein (Bact PBP) DMN9RPO MT DTT DMN9RPO MA Binder DMN9RPO RN Binding affinity for penicillin-binding protein 2a correlates with in vivo activity of beta-lactam antibiotics against methicillin-resistant Staphylococcus aureus. J Infect Dis. 1990 Sep;162(3):705-10. DMN9RPO RU https://pubmed.ncbi.nlm.nih.gov/2387996 DMN9RPO DI DMN9RPO DMN9RPO DN Nafcillin DMN9RPO MI DT3D8F0 DMN9RPO MN Organic anion transporting polypeptide 1B1 (SLCO1B1) DMN9RPO MT DTP DMN9RPO MA Substrate DMN9RPO RN Organic anion transporting polypeptide 1B1: a genetically polymorphic transporter of major importance for hepatic drug uptake. Pharmacol Rev. 2011 Mar;63(1):157-81. DMN9RPO RU http://www.ncbi.nlm.nih.gov/pubmed/21245207 DMVMQ1L DI DMVMQ1L DMVMQ1L DN Nafronyl DMVMQ1L MI TT85JO3 DMVMQ1L MN 5-HT receptor (5HTR) DMVMQ1L MT DTT DMVMQ1L MA Modulator DMVMQ1L RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015 DMVMQ1L RU https://www.accessdata.fda.gov/scripts/cder/drugsatfda/ DMHVBG1 DI DMHVBG1 DMHVBG1 DN Naftifine DMHVBG1 MI TTE14XG DMHVBG1 MN Squalene monooxygenase (SQLE) DMHVBG1 MT DTT DMHVBG1 MA Inhibitor DMHVBG1 RN Characterization of squalene epoxidase activity from the dermatophyte Trichophyton rubrum and its inhibition by terbinafine and other antimycotic agents. Antimicrob Agents Chemother. 1996 Feb;40(2):443-7. DMHVBG1 RU https://pubmed.ncbi.nlm.nih.gov/8834895 DMQ8R4E DI DMQ8R4E DMQ8R4E DN Naftopidil DMQ8R4E MI TTNGILX DMQ8R4E MN Adrenergic receptor alpha-1A (ADRA1A) DMQ8R4E MT DTT DMQ8R4E MA Inhibitor DMQ8R4E RN Pharmacophore identification of alpha(1A)-adrenoceptor antagonists. Bioorg Med Chem Lett. 2005 Feb 1;15(3):657-64. DMQ8R4E RU https://pubmed.ncbi.nlm.nih.gov/15664832 DMQ8R4E DI DMQ8R4E DMQ8R4E DN Naftopidil DMQ8R4E MI DE5IED8 DMQ8R4E MN Cytochrome P450 2C9 (CYP2C9) DMQ8R4E MT DME DMQ8R4E MA Metabolism DMQ8R4E RN Identification of human cytochrome P450 isozymes involved in the metabolism of naftopidil enantiomers in vitro. J Pharm Pharmacol. 2014 Nov;66(11):1534-51. DMQ8R4E RU https://www.ncbi.nlm.nih.gov/pubmed/?term=24944083 DMQ8R4E DI DMQ8R4E DMQ8R4E DN Naftopidil DMQ8R4E MI DEGTFWK DMQ8R4E MN Mephenytoin 4-hydroxylase (CYP2C19) DMQ8R4E MT DME DMQ8R4E MA Metabolism DMQ8R4E RN Identification of human cytochrome P450 isozymes involved in the metabolism of naftopidil enantiomers in vitro. J Pharm Pharmacol. 2014 Nov;66(11):1534-51. DMQ8R4E RU https://www.ncbi.nlm.nih.gov/pubmed/?term=24944083 DMOSQGU DI DMOSQGU DMOSQGU DN Nalbuphine DMOSQGU MI TTQW87Y DMOSQGU MN Opioid receptor kappa (OPRK1) DMOSQGU MT DTT DMOSQGU MA Modulator DMOSQGU RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. DMOSQGU RU https://www.fda.gov/ DMOSQGU DI DMOSQGU DMOSQGU DN Nalbuphine DMOSQGU MI DTUGYRD DMOSQGU MN P-glycoprotein 1 (ABCB1) DMOSQGU MT DTP DMOSQGU MA Substrate DMOSQGU RN Passive permeability and P-glycoprotein-mediated efflux differentiate central nervous system (CNS) and non-CNS marketed drugs. J Pharmacol Exp Ther. 2002 Dec;303(3):1029-37. DMOSQGU RU http://www.ncbi.nlm.nih.gov/pubmed/12438524 DMGD3YH DI DMGD3YH DMGD3YH DN Naldemedine Tosylate DMGD3YH MI TTKWM86 DMGD3YH MN Opioid receptor mu (MOP) DMGD3YH MT DTT DMGD3YH MA Antagonist DMGD3YH RN 2017 FDA drug approvals.Nat Rev Drug Discov. 2018 Feb;17(2):81-85. DMGD3YH RU https://pubmed.ncbi.nlm.nih.gov/29348678 DMA9DHW DI DMA9DHW DMA9DHW DN Nalfurafine hcl DMA9DHW MI TTQW87Y DMA9DHW MN Opioid receptor kappa (OPRK1) DMA9DHW MT DTT DMA9DHW MA Inhibitor DMA9DHW RN Drug design and synthesis of a novel kappa opioid receptor agonist with an oxabicyclo[2.2.2]octane skeleton and its pharmacology. Bioorg Med Chem Lett. 2010 Jan 1;20(1):121-4. DMA9DHW RU https://pubmed.ncbi.nlm.nih.gov/19962305 DMA9DHW DI DMA9DHW DMA9DHW DN Nalfurafine hcl DMA9DHW MI TTKWM86 DMA9DHW MN Opioid receptor mu (MOP) DMA9DHW MT DTT DMA9DHW MA Inhibitor DMA9DHW RN Drug design and synthesis of a novel kappa opioid receptor agonist with an oxabicyclo[2.2.2]octane skeleton and its pharmacology. Bioorg Med Chem Lett. 2010 Jan 1;20(1):121-4. DMA9DHW RU https://pubmed.ncbi.nlm.nih.gov/19962305 DMRM0JV DI DMRM0JV DMRM0JV DN Nalidixic acid DMRM0JV MI TT0IHXV DMRM0JV MN DNA topoisomerase II (TOP2) DMRM0JV MT DTT DMRM0JV MA Inhibitor DMRM0JV RN Activity of fluoroquinolone antibiotics against Plasmodium falciparum in vitro. Antimicrob Agents Chemother. 1988 Aug;32(8):1182-6. DMRM0JV RU https://pubmed.ncbi.nlm.nih.gov/2847647 DM4YWCZ DI DM4YWCZ DM4YWCZ DN Nalmefene DM4YWCZ MI TTN4QDT DM4YWCZ MN Opioid receptor (OPR) DM4YWCZ MT DTT DM4YWCZ MA Antagonist DM4YWCZ RN Unconditioned behavioral effects of the powerful kappa-opioid hallucinogen salvinorin A in nonhuman primates: fast onset and entry into cerebrospin... J Pharmacol Exp Ther. 2009 Feb;328(2):588-97. DM4YWCZ RU https://pubmed.ncbi.nlm.nih.gov/19001155 DML0B41 DI DML0B41 DML0B41 DN Naloxegol DML0B41 MI DE4LYSA DML0B41 MN Cytochrome P450 3A4 (CYP3A4) DML0B41 MT DME DML0B41 MA Metabolism DML0B41 RN Naloxegol: treatment for opioid-induced constipation in chronic non-cancer pain. Ann Pharmacother. 2015 Mar;49(3):360-5. DML0B41 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=25471070 DML0B41 DI DML0B41 DML0B41 DN Naloxegol DML0B41 MI TTKWM86 DML0B41 MN Opioid receptor mu (MOP) DML0B41 MT DTT DML0B41 MA Modulator DML0B41 RN 2014 FDA drug approvals. Nat Rev Drug Discov. 2015 Feb;14(2):77-81. DML0B41 RU https://pubmed.ncbi.nlm.nih.gov/25633781 DML0B41 DI DML0B41 DML0B41 DN Naloxegol DML0B41 MI DTUGYRD DML0B41 MN P-glycoprotein 1 (ABCB1) DML0B41 MT DTP DML0B41 MA Substrate DML0B41 RN Tarascon Pocket Pharmacopoeia 2018 Classic Shirt-Pocket Edition. DML0B41 RU https://books.google.com/books?id=0gBRDwAAQBAJ&pg=PP37&lpg=PP37&dq=Methylergonovine+transporter+uptake+efflex&source=bl&ots=cUTe_ppsmZ&sig=ACfU3U3E_YqrDg0CNEuj8K-7lci47HAnrg&hl=zh-CN&sa=X&ved=2ahUKEwjnj-Dk7d7iAhUsK6YKHd5DBDkQ6AEwEnoECAgQAQ#v=onepage&q&f=false DM3FXMA DI DM3FXMA DM3FXMA DN Naloxone DM3FXMA MI TTKWM86 DM3FXMA MN Opioid receptor mu (MOP) DM3FXMA MT DTT DM3FXMA MA Antagonist DM3FXMA RN OxyContin abuse and overdose. Postgrad Med. 2009 Mar;121(2):163-7. DM3FXMA RU https://pubmed.ncbi.nlm.nih.gov/19332974 DMUL45H DI DMUL45H DMUL45H DN Naltrexone DMUL45H MI TTN4QDT DMUL45H MN Opioid receptor (OPR) DMUL45H MT DTT DMUL45H MA Antagonist DMUL45H RN An evaluation of mu-opioid receptor (OPRM1) as a predictor of naltrexone response in the treatment of alcohol dependence: results from the Combined Pharmacotherapies and Behavioral Interventions for Alcohol Dependence (COMBINE) study. Arch Gen Psychiatry. 2008 Feb;65(2):135-44. DMUL45H RU https://pubmed.ncbi.nlm.nih.gov/18250251 DMUL45H DI DMUL45H DMUL45H DN Naltrexone DMUL45H MI DEYGVN4 DMUL45H MN UDP-glucuronosyltransferase 1A1 (UGT1A1) DMUL45H MT DME DMUL45H MA Metabolism DMUL45H RN In vivo chronic exposure to heroin or naltrexone selectively inhibits liver microsome formation of estradiol-3-glucuronide in the rat. Biochem Pharmacol. 2008 Sep 1;76(5):672-9. DMUL45H RU https://www.ncbi.nlm.nih.gov/pubmed/?term=18639530 DMFWKG1 DI DMFWKG1 DMFWKG1 DN Nandrolone DMFWKG1 MI TTS64P2 DMFWKG1 MN Androgen receptor (AR) DMFWKG1 MT DTT DMFWKG1 MA Agonist DMFWKG1 RN Expression of androgen receptor on fibroblast and hepatocyte of rats after deep second-degree burn caused by scalding. Sichuan Da Xue Xue Bao Yi Xue Ban. 2005 May;36(3):362-4. DMFWKG1 RU https://pubmed.ncbi.nlm.nih.gov/15931869 DMFWKG1 DI DMFWKG1 DMFWKG1 DN Nandrolone DMFWKG1 MI DEQX145 DMFWKG1 MN Aromatase (CYP19A1) DMFWKG1 MT DME DMFWKG1 MA Metabolism DMFWKG1 RN Aromatization of testosterone and 19-nortestosterone by a single enzyme from equine testicular microsomes. Differences from human placental aromatase. J Steroid Biochem. 1988 Jan;29(1):119-25. DMFWKG1 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=3347045 DMJFZDL DI DMJFZDL DMJFZDL DN Naphazoline DMJFZDL MI TTEX248 DMJFZDL MN Dopamine D2 receptor (D2R) DMJFZDL MT DTT DMJFZDL MA Agonist DMJFZDL RN Decongestants in treatment of nasal obstruction. Otolaryngol Pol. 1999;53(3):347-52. DMJFZDL RU https://pubmed.ncbi.nlm.nih.gov/10481510 DMZ5RGV DI DMZ5RGV DMZ5RGV DN Naproxen DMZ5RGV MI DEJGDUW DMZ5RGV MN Cytochrome P450 1A2 (CYP1A2) DMZ5RGV MT DME DMZ5RGV MA Metabolism DMZ5RGV RN Involvement of multiple cytochrome P450 isoforms in naproxen O-demethylation. Eur J Clin Pharmacol. 1997;52(4):293-8. DMZ5RGV RU https://www.ncbi.nlm.nih.gov/pubmed/?term=9248768 DMZ5RGV DI DMZ5RGV DMZ5RGV DN Naproxen DMZ5RGV MI DES5XRU DMZ5RGV MN Cytochrome P450 2C8 (CYP2C8) DMZ5RGV MT DME DMZ5RGV MA Metabolism DMZ5RGV RN Involvement of multiple cytochrome P450 isoforms in naproxen O-demethylation. Eur J Clin Pharmacol. 1997;52(4):293-8. DMZ5RGV RU https://www.ncbi.nlm.nih.gov/pubmed/?term=9248768 DMZ5RGV DI DMZ5RGV DMZ5RGV DN Naproxen DMZ5RGV MI DE5IED8 DMZ5RGV MN Cytochrome P450 2C9 (CYP2C9) DMZ5RGV MT DME DMZ5RGV MA Metabolism DMZ5RGV RN Drug interactions in dentistry: the importance of knowing your CYPs. J Am Dent Assoc. 2004 Mar;135(3):298-311. DMZ5RGV RU https://www.ncbi.nlm.nih.gov/pubmed/?term=15058617 DMZ5RGV DI DMZ5RGV DMZ5RGV DN Naproxen DMZ5RGV MI TT8NGED DMZ5RGV MN Prostaglandin G/H synthase 1 (COX-1) DMZ5RGV MT DTT DMZ5RGV MA Inhibitor DMZ5RGV RN Comparative inhibitory activity of rofecoxib, meloxicam, diclofenac, ibuprofen, and naproxen on COX-2 versus COX-1 in healthy volunteers. J Clin Pharmacol. 2000 Oct;40(10):1109-20. DMZ5RGV RU https://pubmed.ncbi.nlm.nih.gov/11028250 DMZ5RGV DI DMZ5RGV DMZ5RGV DN Naproxen DMZ5RGV MI TTVKILB DMZ5RGV MN Prostaglandin G/H synthase 2 (COX-2) DMZ5RGV MT DTT DMZ5RGV MA Inhibitor DMZ5RGV RN Comparative inhibitory activity of rofecoxib, meloxicam, diclofenac, ibuprofen, and naproxen on COX-2 versus COX-1 in healthy volunteers. J Clin Pharmacol. 2000 Oct;40(10):1109-20. DMZ5RGV RU https://pubmed.ncbi.nlm.nih.gov/11028250 DMZ5RGV DI DMZ5RGV DMZ5RGV DN Naproxen DMZ5RGV MI DEYGVN4 DMZ5RGV MN UDP-glucuronosyltransferase 1A1 (UGT1A1) DMZ5RGV MT DME DMZ5RGV MA Metabolism DMZ5RGV RN Influence of mutations associated with Gilbert and Crigler-Najjar type II syndromes on the glucuronidation kinetics of bilirubin and other UDP-glucuronosyltransferase 1A substrates. Pharmacogenet Genomics. 2007 Dec;17(12):1017-29. DMZ5RGV RU https://www.ncbi.nlm.nih.gov/pubmed/?term=18004206 DMZ5RGV DI DMZ5RGV DMZ5RGV DN Naproxen DMZ5RGV MI DEL5N6Y DMZ5RGV MN UDP-glucuronosyltransferase 1A10 (UGT1A10) DMZ5RGV MT DME DMZ5RGV MA Metabolism DMZ5RGV RN S-Naproxen and desmethylnaproxen glucuronidation by human liver microsomes and recombinant human UDP-glucuronosyltransferases (UGT): role of UGT2B7 in the elimination of naproxen. Br J Clin Pharmacol. 2005 Oct;60(4):423-33. DMZ5RGV RU https://www.ncbi.nlm.nih.gov/pubmed/?term=16187975 DMZ5RGV DI DMZ5RGV DMZ5RGV DN Naproxen DMZ5RGV MI DEF2WXN DMZ5RGV MN UDP-glucuronosyltransferase 1A3 (UGT1A3) DMZ5RGV MT DME DMZ5RGV MA Metabolism DMZ5RGV RN S-Naproxen and desmethylnaproxen glucuronidation by human liver microsomes and recombinant human UDP-glucuronosyltransferases (UGT): role of UGT2B7 in the elimination of naproxen. Br J Clin Pharmacol. 2005 Oct;60(4):423-33. DMZ5RGV RU https://www.ncbi.nlm.nih.gov/pubmed/?term=16187975 DMZ5RGV DI DMZ5RGV DMZ5RGV DN Naproxen DMZ5RGV MI DESD26P DMZ5RGV MN UDP-glucuronosyltransferase 1A6 (UGT1A6) DMZ5RGV MT DME DMZ5RGV MA Metabolism DMZ5RGV RN S-Naproxen and desmethylnaproxen glucuronidation by human liver microsomes and recombinant human UDP-glucuronosyltransferases (UGT): role of UGT2B7 in the elimination of naproxen. Br J Clin Pharmacol. 2005 Oct;60(4):423-33. DMZ5RGV RU https://www.ncbi.nlm.nih.gov/pubmed/?term=16187975 DMZ5RGV DI DMZ5RGV DMZ5RGV DN Naproxen DMZ5RGV MI DE85D2P DMZ5RGV MN UDP-glucuronosyltransferase 1A9 (UGT1A9) DMZ5RGV MT DME DMZ5RGV MA Metabolism DMZ5RGV RN S-Naproxen and desmethylnaproxen glucuronidation by human liver microsomes and recombinant human UDP-glucuronosyltransferases (UGT): role of UGT2B7 in the elimination of naproxen. Br J Clin Pharmacol. 2005 Oct;60(4):423-33. DMZ5RGV RU https://www.ncbi.nlm.nih.gov/pubmed/?term=16187975 DMZ5RGV DI DMZ5RGV DMZ5RGV DN Naproxen DMZ5RGV MI DEB3CV1 DMZ5RGV MN UDP-glucuronosyltransferase 2B7 (UGT2B7) DMZ5RGV MT DME DMZ5RGV MA Metabolism DMZ5RGV RN Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. DMZ5RGV RU https://www.ncbi.nlm.nih.gov/pubmed/?term=19515014 DMO50U2 DI DMO50U2 DMO50U2 DN Naratriptan DMO50U2 MI TTK8CXU DMO50U2 MN 5-HT 1B receptor (HTR1B) DMO50U2 MT DTT DMO50U2 MA Agonist DMO50U2 RN Triptans in pregnancy. Ther Drug Monit. 2008 Feb;30(1):5-9. DMO50U2 RU https://pubmed.ncbi.nlm.nih.gov/18223456 DMO50U2 DI DMO50U2 DMO50U2 DN Naratriptan DMO50U2 MI DERE4TU DMO50U2 MN Monoamine oxidase type A (MAO-A) DMO50U2 MT DME DMO50U2 MA Metabolism DMO50U2 RN Migraine pharmacotherapy with oral triptans: a rational approach to clinical management. Expert Opin Pharmacother. 2000 Mar;1(3):391-404. DMO50U2 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=11249525 DMO50U2 DI DMO50U2 DMO50U2 DN Naratriptan DMO50U2 MI DTT79CX DMO50U2 MN Organic cation transporter 1 (SLC22A1) DMO50U2 MT DTP DMO50U2 MA Substrate DMO50U2 RN OCT1 mediates hepatic uptake of sumatriptan and loss-of-function OCT1 polymorphisms affect sumatriptan pharmacokinetics. Clin Pharmacol Ther. 2016 Jun;99(6):633-41. DMO50U2 RU http://www.ncbi.nlm.nih.gov/pubmed/26659468 DMFEHXD DI DMFEHXD DMFEHXD DN Natamycin DMFEHXD MI TTAH0B3 DMFEHXD MN Fungal Cell membrane (Fung CM) DMFEHXD MT DTT DMFEHXD MA Binder DMFEHXD RN Natamycin blocks fungal growth by binding specifically to ergosterol without permeabilizing the membrane. J Biol Chem. 2008 Mar 7;283(10):6393-401. DMFEHXD RU https://pubmed.ncbi.nlm.nih.gov/18165687 DMLK2QH DI DMLK2QH DMLK2QH DN Nateglinide DMLK2QH MI DE5IED8 DMLK2QH MN Cytochrome P450 2C9 (CYP2C9) DMLK2QH MT DME DMLK2QH MA Metabolism DMLK2QH RN Drug-drug and food-drug pharmacokinetic interactions with new insulinotropic agents repaglinide and nateglinide. Clin Pharmacokinet. 2007;46(2):93-108. DMLK2QH RU https://www.ncbi.nlm.nih.gov/pubmed/?term=17253883 DMLK2QH DI DMLK2QH DMLK2QH DN Nateglinide DMLK2QH MI DECB0K3 DMLK2QH MN Cytochrome P450 2D6 (CYP2D6) DMLK2QH MT DME DMLK2QH MA Metabolism DMLK2QH RN Influence of CYP2C9 and CYP2D6 polymorphisms on the pharmacokinetics of nateglinide in genotyped healthy volunteers. Clin Pharmacokinet. 2004;43(4):267-78. DMLK2QH RU https://www.ncbi.nlm.nih.gov/pubmed/?term=15005635 DMLK2QH DI DMLK2QH DMLK2QH DN Nateglinide DMLK2QH MI DE4LYSA DMLK2QH MN Cytochrome P450 3A4 (CYP3A4) DMLK2QH MT DME DMLK2QH MA Metabolism DMLK2QH RN Drug-drug and food-drug pharmacokinetic interactions with new insulinotropic agents repaglinide and nateglinide. Clin Pharmacokinet. 2007;46(2):93-108. DMLK2QH RU https://www.ncbi.nlm.nih.gov/pubmed/?term=17253883 DMLK2QH DI DMLK2QH DMLK2QH DN Nateglinide DMLK2QH MI DEIBDNY DMLK2QH MN Cytochrome P450 3A5 (CYP3A5) DMLK2QH MT DME DMLK2QH MA Metabolism DMLK2QH RN Drug Interactions Flockhart Table DMLK2QH RU https://drug-interactions.medicine.iu.edu/Main-Table.aspx DMLK2QH DI DMLK2QH DMLK2QH DN Nateglinide DMLK2QH MI DERD86B DMLK2QH MN Cytochrome P450 3A7 (CYP3A7) DMLK2QH MT DME DMLK2QH MA Metabolism DMLK2QH RN Drug Interactions Flockhart Table DMLK2QH RU https://drug-interactions.medicine.iu.edu/Main-Table.aspx DMLK2QH DI DMLK2QH DMLK2QH DN Nateglinide DMLK2QH MI DT3I124 DMLK2QH MN Monocarboxylate transporter 6 (SLC16A5) DMLK2QH MT DTP DMLK2QH MA Substrate DMLK2QH RN Quercetin, Morin, Luteolin, and Phloretin Are Dietary Flavonoid Inhibitors of Monocarboxylate Transporter 6. Mol Pharm. 2017 Sep 5;14(9):2930-2936. DMLK2QH RU http://www.ncbi.nlm.nih.gov/pubmed/28513167 DMLK2QH DI DMLK2QH DMLK2QH DN Nateglinide DMLK2QH MI DT3D8F0 DMLK2QH MN Organic anion transporting polypeptide 1B1 (SLCO1B1) DMLK2QH MT DTP DMLK2QH MA Substrate DMLK2QH RN Organic Anion Transporter 2-Mediated Hepatic Uptake Contributes to the Clearance of High-Permeability-Low-Molecular-Weight Acid and Zwitterion Drugs: Evaluation Using 25 Drugs. J Pharmacol Exp Ther. 2018 Nov;367(2):322-334. DMLK2QH RU http://www.ncbi.nlm.nih.gov/pubmed/30135178 DMLK2QH DI DMLK2QH DMLK2QH DN Nateglinide DMLK2QH MI DT9C1TS DMLK2QH MN Organic anion transporting polypeptide 1B3 (SLCO1B3) DMLK2QH MT DTP DMLK2QH MA Substrate DMLK2QH RN FDA Drug Development and Drug Interactions DMLK2QH RU https://www.fda.gov/drugs/developmentapprovalprocess/developmentresources/druginteractionslabeling/ucm093664.htm#table3-2 DMLK2QH DI DMLK2QH DMLK2QH DN Nateglinide DMLK2QH MI TT1VOHK DMLK2QH MN Potassium channel unspecific (KC) DMLK2QH MT DTT DMLK2QH MA Modulator DMLK2QH RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. DMLK2QH RU https://www.fda.gov/ DMLK2QH DI DMLK2QH DMLK2QH DN Nateglinide DMLK2QH MI DE073H6 DMLK2QH MN Prostaglandin G/H synthase 1 (COX-1) DMLK2QH MT DME DMLK2QH MA Metabolism DMLK2QH RN Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. DMLK2QH RU https://www.ncbi.nlm.nih.gov/pubmed/?term=19515014 DMLK2QH DI DMLK2QH DMLK2QH DN Nateglinide DMLK2QH MI DE85D2P DMLK2QH MN UDP-glucuronosyltransferase 1A9 (UGT1A9) DMLK2QH MT DME DMLK2QH MA Metabolism DMLK2QH RN Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. DMLK2QH RU https://www.ncbi.nlm.nih.gov/pubmed/?term=19515014 DM7F1PA DI DM7F1PA DM7F1PA DN Nebivolol DM7F1PA MI TTR6W5O DM7F1PA MN Adrenergic receptor beta-1 (ADRB1) DM7F1PA MT DTT DM7F1PA MA Antagonist DM7F1PA RN Nitric oxide mechanisms of nebivolol. Ther Adv Cardiovasc Dis. 2009 Aug;3(4):317-27. DM7F1PA RU https://pubmed.ncbi.nlm.nih.gov/19443516 DM7F1PA DI DM7F1PA DM7F1PA DN Nebivolol DM7F1PA MI DECB0K3 DM7F1PA MN Cytochrome P450 2D6 (CYP2D6) DM7F1PA MT DME DM7F1PA MA Metabolism DM7F1PA RN Nebivolol: a review of its clinical and pharmacological characteristics. Int J Clin Pharmacol Ther. 2006 Aug;44(8):344-57. DM7F1PA RU https://www.ncbi.nlm.nih.gov/pubmed/?term=16961165 DM7F1PA DI DM7F1PA DM7F1PA DN Nebivolol DM7F1PA MI DEGTFWK DM7F1PA MN Mephenytoin 4-hydroxylase (CYP2C19) DM7F1PA MT DME DM7F1PA MA Metabolism DM7F1PA RN Evaluation of 24 CYP2D6 variants on the metabolism of nebivolol in vitro. Drug Metab Dispos. 2016 Nov;44(11):1828-1831. DM7F1PA RU https://www.ncbi.nlm.nih.gov/pubmed/?term=27538917 DMKOJSN DI DMKOJSN DMKOJSN DN Necitumumab DMKOJSN MI TTGKNB4 DMKOJSN MN Epidermal growth factor receptor (EGFR) DMKOJSN MT DTT DMKOJSN MA Modulator DMKOJSN RN Rindopepimut, a 14-mer injectable peptide vaccine against EGFRvIII for the potential treatment of glioblastoma multiforme. Curr Opin Mol Ther. 2010 Dec;12(6):741-54. DMKOJSN RU https://pubmed.ncbi.nlm.nih.gov/21154166 DM4ZS8M DI DM4ZS8M DM4ZS8M DN Nefazodone DM4ZS8M MI TTWJBZ5 DM4ZS8M MN 5-HT 2C receptor (HTR2C) DM4ZS8M MT DTT DM4ZS8M MA Antagonist DM4ZS8M RN Serotonin 5-HT2C receptors as a target for the treatment of depressive and anxious states: focus on novel therapeutic strategies. Therapie. 2005 Sep-Oct;60(5):441-60. DM4ZS8M RU https://pubmed.ncbi.nlm.nih.gov/16433010 DM4ZS8M DI DM4ZS8M DM4ZS8M DN Nefazodone DM4ZS8M MI DECB0K3 DM4ZS8M MN Cytochrome P450 2D6 (CYP2D6) DM4ZS8M MT DME DM4ZS8M MA Metabolism DM4ZS8M RN Nefazodone, meta-chlorophenylpiperazine, and their metabolites in vitro: cytochromes mediating transformation, and P450-3A4 inhibitory actions. Psychopharmacology (Berl). 1999 Jul;145(1):113-22. DM4ZS8M RU https://www.ncbi.nlm.nih.gov/pubmed/?term=10445380 DM4ZS8M DI DM4ZS8M DM4ZS8M DN Nefazodone DM4ZS8M MI DE4LYSA DM4ZS8M MN Cytochrome P450 3A4 (CYP3A4) DM4ZS8M MT DME DM4ZS8M MA Metabolism DM4ZS8M RN Nefazodone, meta-chlorophenylpiperazine, and their metabolites in vitro: cytochromes mediating transformation, and P450-3A4 inhibitory actions. Psychopharmacology (Berl). 1999 Jul;145(1):113-22. DM4ZS8M RU https://www.ncbi.nlm.nih.gov/pubmed/?term=10445380 DMB6VEG DI DMB6VEG DMB6VEG DN Nelarabine DMB6VEG MI DEDQHBV DMB6VEG MN Adenosine aminohydrolase (ADA) DMB6VEG MT DME DMB6VEG MA Metabolism DMB6VEG RN Profile of nelarabine: use in the treatment of T-cell acute lymphoblastic leukemia. Onco Targets Ther. 2009 Feb 18;2:219-28. DMB6VEG RU https://www.ncbi.nlm.nih.gov/pubmed/?term=20616909 DMB6VEG DI DMB6VEG DMB6VEG DN Nelarabine DMB6VEG MI TTUBNVO DMB6VEG MN DNA synthesis (DNA synth) DMB6VEG MT DTT DMB6VEG MA Binder DMB6VEG RN Nelarabine. Drugs. 2008;68(4):439-47. DMB6VEG RU https://pubmed.ncbi.nlm.nih.gov/18318562 DMFX6G8 DI DMFX6G8 DMFX6G8 DN Nelfinavir mesylate DMFX6G8 MI DE4LYSA DMFX6G8 MN Cytochrome P450 3A4 (CYP3A4) DMFX6G8 MT DME DMFX6G8 MA Metabolism DMFX6G8 RN Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. DMFX6G8 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=19515014 DMFX6G8 DI DMFX6G8 DMFX6G8 DN Nelfinavir mesylate DMFX6G8 MI DEIBDNY DMFX6G8 MN Cytochrome P450 3A5 (CYP3A5) DMFX6G8 MT DME DMFX6G8 MA Metabolism DMFX6G8 RN Differential inhibition of cytochrome P450 3A4, 3A5 and 3A7 by five human immunodeficiency virus (HIV) protease inhibitors in vitro. Basic Clin Pharmacol Toxicol. 2006 Jan;98(1):79-85. DMFX6G8 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=16433896 DMFX6G8 DI DMFX6G8 DMFX6G8 DN Nelfinavir mesylate DMFX6G8 MI DERD86B DMFX6G8 MN Cytochrome P450 3A7 (CYP3A7) DMFX6G8 MT DME DMFX6G8 MA Metabolism DMFX6G8 RN Differential inhibition of cytochrome P450 3A4, 3A5 and 3A7 by five human immunodeficiency virus (HIV) protease inhibitors in vitro. Basic Clin Pharmacol Toxicol. 2006 Jan;98(1):79-85. DMFX6G8 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=16433896 DMFX6G8 DI DMFX6G8 DMFX6G8 DN Nelfinavir mesylate DMFX6G8 MI DEGTFWK DMFX6G8 MN Mephenytoin 4-hydroxylase (CYP2C19) DMFX6G8 MT DME DMFX6G8 MA Metabolism DMFX6G8 RN Impact of CYP2C19 polymorphism on the pharmacokinetics of nelfinavir in patients with pancreatic cancer. Br J Clin Pharmacol. 2015 Aug;80(2):267-75. DMFX6G8 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=25752914 DMY0EKH DI DMY0EKH DMY0EKH DN Nemonapride DMY0EKH MI TTEX248 DMY0EKH MN Dopamine D2 receptor (D2R) DMY0EKH MT DTT DMY0EKH MA Agonist DMY0EKH RN The pipeline and future of drug development in schizophrenia. Mol Psychiatry. 2007 Oct;12(10):904-22. DMY0EKH RU https://pubmed.ncbi.nlm.nih.gov/17667958 DM0S9Z1 DI DM0S9Z1 DM0S9Z1 DN Nemonoxacin DM0S9Z1 MI TTN6J5F DM0S9Z1 MN Bacterial DNA gyrase (Bact gyrase) DM0S9Z1 MT DTT DM0S9Z1 MA Inhibitor DM0S9Z1 RN Nemonoxacin: first global approval. Drugs. 2014 Aug;74(12):1445-53. DM0S9Z1 RU https://pubmed.ncbi.nlm.nih.gov/25079302 DMPWCTH DI DMPWCTH DMPWCTH DN Neocarzinostatin DMPWCTH MI TTUTN1I DMPWCTH MN Human Deoxyribonucleic acid (hDNA) DMPWCTH MT DTT DMPWCTH MA Modulator DMPWCTH RN Natural products as sources of new drugs over the last 25 years. J Nat Prod. 2007 Mar;70(3):461-77. DMPWCTH RU https://pubmed.ncbi.nlm.nih.gov/17309302 DM6T2J3 DI DM6T2J3 DM6T2J3 DN Neostigmine DM6T2J3 MI TT1RS9F DM6T2J3 MN Acetylcholinesterase (AChE) DM6T2J3 MT DTT DM6T2J3 MA Inhibitor DM6T2J3 RN Screening of acetylcholinesterase inhibitors by CE after enzymatic reaction at capillary inlet. J Sep Sci. 2009 May;32(10):1748-56. DM6T2J3 RU https://pubmed.ncbi.nlm.nih.gov/19472276 DM6T2J3 DI DM6T2J3 DM6T2J3 DN Neostigmine DM6T2J3 MI DTUGYRD DM6T2J3 MN P-glycoprotein 1 (ABCB1) DM6T2J3 MT DTP DM6T2J3 MA Substrate DM6T2J3 RN Improving the prediction of the brain disposition for orally administered drugs using BDDCS. Adv Drug Deliv Rev. 2012 Jan;64(1):95-109. DM6T2J3 RU https://doi.org/10.1016/j.addr.2011.12.008 DMYK490 DI DMYK490 DMYK490 DN Nepafenac DMYK490 MI TTK0943 DMYK490 MN Prostaglandin G/H synthase (COX) DMYK490 MT DTT DMYK490 MA Inhibitor DMYK490 RN Topical nepafenac inhibits ocular neovascularization. Invest Ophthalmol Vis Sci. 2003 Jan;44(1):409-15. DMYK490 RU https://pubmed.ncbi.nlm.nih.gov/12506103 DMEDU7B DI DMEDU7B DMEDU7B DN NERATINIB MALEATE DMEDU7B MI TTGKNB4 DMEDU7B MN Epidermal growth factor receptor (EGFR) DMEDU7B MT DTT DMEDU7B MA Antagonist DMEDU7B RN 2017 FDA drug approvals.Nat Rev Drug Discov. 2018 Feb;17(2):81-85. DMEDU7B RU https://pubmed.ncbi.nlm.nih.gov/29348678 DMEDU7B DI DMEDU7B DMEDU7B DN NERATINIB MALEATE DMEDU7B MI TT6EO5L DMEDU7B MN Erbb2 tyrosine kinase receptor (HER2) DMEDU7B MT DTT DMEDU7B MA Antagonist DMEDU7B RN 2017 FDA drug approvals.Nat Rev Drug Discov. 2018 Feb;17(2):81-85. DMEDU7B RU https://pubmed.ncbi.nlm.nih.gov/29348678 DMMPG5V DI DMMPG5V DMMPG5V DN NERIDRONIC ACID DMMPG5V MI TTIKWV4 DMMPG5V MN Geranyltranstransferase (FDPS) DMMPG5V MT DTT DMMPG5V MA Inhibitor DMMPG5V RN Structure-activity relationships among the nitrogen containing bisphosphonates in clinical use and other analogues: time-dependent inhibition of hu... J Med Chem. 2008 Apr 10;51(7):2187-95. DMMPG5V RU https://pubmed.ncbi.nlm.nih.gov/18327899 DMFOIA8 DI DMFOIA8 DMFOIA8 DN Nesiritide DMFOIA8 MI TTJME02 DMFOIA8 MN Atrial natriuretic peptide receptor A (NPR1) DMFOIA8 MT DTT DMFOIA8 MA Binder DMFOIA8 RN The efficacy and safety of B-type natriuretic peptide (nesiritide) in patients with renal insufficiency and acutely decompensated congestive heart failure. Nephrol Dial Transplant. 2004 Feb;19(2):391-9. DMFOIA8 RU https://pubmed.ncbi.nlm.nih.gov/14736964 DM0LPI9 DI DM0LPI9 DM0LPI9 DN Netarsudil DM0LPI9 MI TTAWNKZ DM0LPI9 MN Norepinephrine transporter (NET) DM0LPI9 MT DTT DM0LPI9 MA Modulator DM0LPI9 RN Effect of 0.04% AR-13324, a ROCK, and norepinephrine transporter inhibitor, on aqueous humor dynamics in normotensive monkey eyes. J Glaucoma. 2015 Jan;24(1):51-4. DM0LPI9 RU https://pubmed.ncbi.nlm.nih.gov/25535688 DM0LPI9 DI DM0LPI9 DM0LPI9 DN Netarsudil DM0LPI9 MI TTMQO60 DM0LPI9 MN Rho-associated protein kinase (ROCK) DM0LPI9 MT DTT DM0LPI9 MA Modulator DM0LPI9 RN Effect of 0.04% AR-13324, a ROCK, and norepinephrine transporter inhibitor, on aqueous humor dynamics in normotensive monkey eyes. J Glaucoma. 2015 Jan;24(1):51-4. DM0LPI9 RU https://pubmed.ncbi.nlm.nih.gov/25535688 DM0LPI9 DI DM0LPI9 DM0LPI9 DN Netarsudil DM0LPI9 MI TTZN7RP DM0LPI9 MN Rho-associated protein kinase 1 (ROCK1) DM0LPI9 MT DTT DM0LPI9 MA Inhibitor DM0LPI9 RN 2017 FDA drug approvals.Nat Rev Drug Discov. 2018 Feb;17(2):81-85. DM0LPI9 RU https://pubmed.ncbi.nlm.nih.gov/29348678 DMRD1QK DI DMRD1QK DMRD1QK DN Netilmicin DMRD1QK MI DEJADS9 DMRD1QK MN Aminoglycoside N-acetyltransferase (aacC2) DMRD1QK MT DME DMRD1QK MA Metabolism DMRD1QK RN Relationship between antimicrobial resistance and aminoglycoside-modifying enzyme gene expressions in Acinetobacter baumannii. Chin Med J (Engl). 2005 Jan 20;118(2):141-5. DMRD1QK RU https://pubmed.ncbi.nlm.nih.gov/15667800 DMRD1QK DI DMRD1QK DMRD1QK DN Netilmicin DMRD1QK MI DEWPAJD DMRD1QK MN Aminoglycoside O-phosphotransferase (aphA6) DMRD1QK MT DME DMRD1QK MA Metabolism DMRD1QK RN Relationship between antimicrobial resistance and aminoglycoside-modifying enzyme gene expressions in Acinetobacter baumannii. Chin Med J (Engl). 2005 Jan 20;118(2):141-5. DMRD1QK RU https://pubmed.ncbi.nlm.nih.gov/15667800 DMRD1QK DI DMRD1QK DMRD1QK DN Netilmicin DMRD1QK MI DEZV4AP DMRD1QK MN RNA cytidine acetyltransferase (hALP) DMRD1QK MT DME DMRD1QK MA Metabolism DMRD1QK RN Aminoglycoside resistance resulting from tight drug binding to an altered aminoglycoside acetyltransferase. Antimicrob Agents Chemother. 2003 May;47(5):1577-83. DMRD1QK RU https://www.ncbi.nlm.nih.gov/pubmed/?term=12709325 DMRD1QK DI DMRD1QK DMRD1QK DN Netilmicin DMRD1QK MI TTQ8KVI DMRD1QK MN Staphylococcus 30S ribosomal subunit (Stap-coc pbp2) DMRD1QK MT DTT DMRD1QK MA Binder DMRD1QK RN Ribosomal resistance in the gentamicin producer organism Micromonospora purpurea. Antimicrob Agents Chemother. 1982 Aug;22(2):231-6. DMRD1QK RU https://pubmed.ncbi.nlm.nih.gov/6927285 DM6HX9B DI DM6HX9B DM6HX9B DN Nevirapine DM6HX9B MI DEJVYAZ DM6HX9B MN Cytochrome P450 2A6 (CYP2A6) DM6HX9B MT DME DM6HX9B MA Metabolism DM6HX9B RN Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. DM6HX9B RU https://www.ncbi.nlm.nih.gov/pubmed/?term=19515014 DM6HX9B DI DM6HX9B DM6HX9B DN Nevirapine DM6HX9B MI DEPKLMQ DM6HX9B MN Cytochrome P450 2B6 (CYP2B6) DM6HX9B MT DME DM6HX9B MA Metabolism DM6HX9B RN RAT CYP3A and CYP2B1/2 were not associated with nevirapine-induced hepatotoxicity. Methods Find Exp Clin Pharmacol. 2006 Sep;28(7):423-31. DM6HX9B RU https://www.ncbi.nlm.nih.gov/pubmed/?term=17003847 DM6HX9B DI DM6HX9B DM6HX9B DN Nevirapine DM6HX9B MI DE5IED8 DM6HX9B MN Cytochrome P450 2C9 (CYP2C9) DM6HX9B MT DME DM6HX9B MA Metabolism DM6HX9B RN Inhibition of human cytochrome P450 isoforms by nonnucleoside reverse transcriptase inhibitors. J Clin Pharmacol. 2001 Jan;41(1):85-91. DM6HX9B RU https://www.ncbi.nlm.nih.gov/pubmed/?term=11225565 DM6HX9B DI DM6HX9B DM6HX9B DN Nevirapine DM6HX9B MI DECB0K3 DM6HX9B MN Cytochrome P450 2D6 (CYP2D6) DM6HX9B MT DME DM6HX9B MA Metabolism DM6HX9B RN Characterization of the in vitro biotransformation of the HIV-1 reverse transcriptase inhibitor nevirapine by human hepatic cytochromes P-450. Drug Metab Dispos. 1999 Dec;27(12):1488-95. DM6HX9B RU https://www.ncbi.nlm.nih.gov/pubmed/?term=10570031 DM6HX9B DI DM6HX9B DM6HX9B DN Nevirapine DM6HX9B MI DE4LYSA DM6HX9B MN Cytochrome P450 3A4 (CYP3A4) DM6HX9B MT DME DM6HX9B MA Metabolism DM6HX9B RN Characterization of the in vitro biotransformation of the HIV-1 reverse transcriptase inhibitor nevirapine by human hepatic cytochromes P-450. Drug Metab Dispos. 1999 Dec;27(12):1488-95. DM6HX9B RU https://www.ncbi.nlm.nih.gov/pubmed/?term=10570031 DM6HX9B DI DM6HX9B DM6HX9B DN Nevirapine DM6HX9B MI DEIBDNY DM6HX9B MN Cytochrome P450 3A5 (CYP3A5) DM6HX9B MT DME DM6HX9B MA Metabolism DM6HX9B RN Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. DM6HX9B RU https://www.ncbi.nlm.nih.gov/pubmed/?term=19515014 DM6HX9B DI DM6HX9B DM6HX9B DN Nevirapine DM6HX9B MI DERD86B DM6HX9B MN Cytochrome P450 3A7 (CYP3A7) DM6HX9B MT DME DM6HX9B MA Metabolism DM6HX9B RN Helices F-G are important for the substrate specificities of CYP3A7. Drug Metab Dispos. 2007 Mar;35(3):484-92. DM6HX9B RU https://www.ncbi.nlm.nih.gov/pubmed/?term=17178770 DM6HX9B DI DM6HX9B DM6HX9B DN Nevirapine DM6HX9B MI TT84ETX DM6HX9B MN Human immunodeficiency virus Reverse transcriptase (HIV RT) DM6HX9B MT DTT DM6HX9B MA Modulator DM6HX9B RN HIV-1 reverse transcriptase complex with DNA and nevirapine reveals non-nucleoside inhibition mechanism.Nat Struct Mol Biol.2012 Jan 22;19(2):253-9. DM6HX9B RU https://www.ncbi.nlm.nih.gov/pubmed/22266819 DM6HX9B DI DM6HX9B DM6HX9B DN Nevirapine DM6HX9B MI DTUGYRD DM6HX9B MN P-glycoprotein 1 (ABCB1) DM6HX9B MT DTP DM6HX9B MA Substrate DM6HX9B RN Human intestinal transporter database: QSAR modeling and virtual profiling of drug uptake, efflux and interactions. Pharm Res. 2013 Apr;30(4):996-1007. DM6HX9B RU https://doi.org/10.1007/s11095-012-0935-x DMCDYW7 DI DMCDYW7 DMCDYW7 DN Nicardipine DMCDYW7 MI DTI7UX6 DMCDYW7 MN Breast cancer resistance protein (ABCG2) DMCDYW7 MT DTP DMCDYW7 MA Substrate DMCDYW7 RN Mammalian drug efflux transporters of the ATP binding cassette (ABC) family in multidrug resistance: A review of the past decade. Cancer Lett. 2016 Jan 1;370(1):153-64. DMCDYW7 RU http://www.ncbi.nlm.nih.gov/pubmed/26499806 DMCDYW7 DI DMCDYW7 DMCDYW7 DN Nicardipine DMCDYW7 MI TT5HONZ DMCDYW7 MN Calcium channel unspecific (CaC) DMCDYW7 MT DTT DMCDYW7 MA Blocker DMCDYW7 RN Effect of intracoronary nicardipine on cardiac enzymes after elective percutaneous coronary intervention. Clin Cardiol. 2009 Jun;32(6):315-20. DMCDYW7 RU https://pubmed.ncbi.nlm.nih.gov/19569065 DMCDYW7 DI DMCDYW7 DMCDYW7 DN Nicardipine DMCDYW7 MI DES5XRU DMCDYW7 MN Cytochrome P450 2C8 (CYP2C8) DMCDYW7 MT DME DMCDYW7 MA Metabolism DMCDYW7 RN Summary of information on human CYP enzymes: human P450 metabolism data. Drug Metab Rev. 2002 Feb-May;34(1-2):83-448. DMCDYW7 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=11996015 DMCDYW7 DI DMCDYW7 DMCDYW7 DN Nicardipine DMCDYW7 MI DECB0K3 DMCDYW7 MN Cytochrome P450 2D6 (CYP2D6) DMCDYW7 MT DME DMCDYW7 MA Metabolism DMCDYW7 RN Inhibitory effects of nicardipine to cytochrome P450 (CYP) in human liver microsomes. Biol Pharm Bull. 2005 May;28(5):882-5. DMCDYW7 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=15863898 DMCDYW7 DI DMCDYW7 DMCDYW7 DN Nicardipine DMCDYW7 MI DEVDYN7 DMCDYW7 MN Cytochrome P450 2E1 (CYP2E1) DMCDYW7 MT DME DMCDYW7 MA Metabolism DMCDYW7 RN Summary of information on human CYP enzymes: human P450 metabolism data. Drug Metab Rev. 2002 Feb-May;34(1-2):83-448. DMCDYW7 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=11996015 DMCDYW7 DI DMCDYW7 DMCDYW7 DN Nicardipine DMCDYW7 MI DE4LYSA DMCDYW7 MN Cytochrome P450 3A4 (CYP3A4) DMCDYW7 MT DME DMCDYW7 MA Metabolism DMCDYW7 RN Inhibitory effects of nicardipine to cytochrome P450 (CYP) in human liver microsomes. Biol Pharm Bull. 2005 May;28(5):882-5. DMCDYW7 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=15863898 DMCDYW7 DI DMCDYW7 DMCDYW7 DN Nicardipine DMCDYW7 MI DTUGYRD DMCDYW7 MN P-glycoprotein 1 (ABCB1) DMCDYW7 MT DTP DMCDYW7 MA Substrate DMCDYW7 RN Modulation of drug-stimulated ATPase activity of human MDR1/P-glycoprotein by cholesterol. Biochem J. 2007 Jan 15;401(2):597-605. DMCDYW7 RU http://www.ncbi.nlm.nih.gov/pubmed/17029589 DMBCM8L DI DMBCM8L DMBCM8L DN Nicergoline DMBCM8L MI TTQ8AFT DMBCM8L MN Adrenergic receptor Alpha-2 (ADRA2) DMBCM8L MT DTT DMBCM8L MA Antagonist DMBCM8L RN Effect of non-selective alpha-adrenergic receptor antagonist nicergoline on the activity of neurons in the ventral lateral thalamic nucleus. Fiziol Zh. 2005;51(4):29-35. DMBCM8L RU https://pubmed.ncbi.nlm.nih.gov/16201147 DMBCM8L DI DMBCM8L DMBCM8L DN Nicergoline DMBCM8L MI DECB0K3 DMBCM8L MN Cytochrome P450 2D6 (CYP2D6) DMBCM8L MT DME DMBCM8L MA Metabolism DMBCM8L RN Involvement of CYP2D6 but not CYP2C19 in nicergoline metabolism in humans. Br J Clin Pharmacol. 1996 Dec;42(6):707-11. DMBCM8L RU https://www.ncbi.nlm.nih.gov/pubmed/?term=8971425 DMJAGXQ DI DMJAGXQ DMJAGXQ DN Niclosamide DMJAGXQ MI DE5IED8 DMJAGXQ MN Cytochrome P450 2C9 (CYP2C9) DMJAGXQ MT DME DMJAGXQ MA Metabolism DMJAGXQ RN Generation and evaluation of a CYP2C9 heteroactivation pharmacophore. J Pharmacol Exp Ther. 2003 Dec;307(3):878-87. DMJAGXQ RU https://www.ncbi.nlm.nih.gov/pubmed/?term=14557374 DMJAGXQ DI DMJAGXQ DMJAGXQ DN Niclosamide DMJAGXQ MI DE0K82S DMJAGXQ MN Nitroreductase (NTR) DMJAGXQ MT DME DMJAGXQ MA Metabolism DMJAGXQ RN CYP1A1 and Cnr nitroreductase bioactivated niclosamide in vitro. Mutagenesis. 2013 Nov;28(6):645-51. DMJAGXQ RU https://pubmed.ncbi.nlm.nih.gov/23956140 DMIYJFV DI DMIYJFV DMIYJFV DN Nicorandil DMIYJFV MI TTEF5MJ DMIYJFV MN ATP-binding cassette transporter C9 (ABCC9) DMIYJFV MT DTT DMIYJFV MA Activator DMIYJFV RN A functional role of the C-terminal 42 amino acids of SUR2A and SUR2B in the physiology and pharmacology of cardiovascular ATP-sensitive K(+) chann... J Mol Cell Cardiol. 2005 Jul;39(1):1-6. DMIYJFV RU https://pubmed.ncbi.nlm.nih.gov/15978900 DMUPE07 DI DMUPE07 DMUPE07 DN Nicotinamide DMUPE07 MI DEVDYN7 DMUPE07 MN Cytochrome P450 2E1 (CYP2E1) DMUPE07 MT DME DMUPE07 MA Metabolism DMUPE07 RN Nicotinamide N-oxidation by CYP2E1 in human liver microsomes. Drug Metab Dispos. 2013 Mar;41(3):550-3. DMUPE07 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=23418369 DMUPE07 DI DMUPE07 DMUPE07 DN Nicotinamide DMUPE07 MI TTVDSZ0 DMUPE07 MN Poly [ADP-ribose] polymerase 1 (PARP1) DMUPE07 MT DTT DMUPE07 MA Binder DMUPE07 RN beta-1,2,3-Triazolyl-nucleosides as nicotinamide riboside mimics. Nucleosides Nucleotides Nucleic Acids. 2009 Mar;28(3):238-59. DMUPE07 RU https://pubmed.ncbi.nlm.nih.gov/19333861 DMWX5CO DI DMWX5CO DMWX5CO DN Nicotine DMWX5CO MI DE6OQ3W DMWX5CO MN Cytochrome P450 1A1 (CYP1A1) DMWX5CO MT DME DMWX5CO MA Metabolism DMWX5CO RN Roles of CYP2A6 and CYP2B6 in nicotine C-oxidation by human liver microsomes. Arch Toxicol. 1999 Mar;73(2):65-70. DMWX5CO RU https://www.ncbi.nlm.nih.gov/pubmed/?term=10350185 DMWX5CO DI DMWX5CO DMWX5CO DN Nicotine DMWX5CO MI DEJGDUW DMWX5CO MN Cytochrome P450 1A2 (CYP1A2) DMWX5CO MT DME DMWX5CO MA Metabolism DMWX5CO RN Roles of CYP2A6 and CYP2B6 in nicotine C-oxidation by human liver microsomes. Arch Toxicol. 1999 Mar;73(2):65-70. DMWX5CO RU https://www.ncbi.nlm.nih.gov/pubmed/?term=10350185 DMWX5CO DI DMWX5CO DMWX5CO DN Nicotine DMWX5CO MI DEXZA9U DMWX5CO MN Cytochrome P450 2A13 (CYP2A13) DMWX5CO MT DME DMWX5CO MA Metabolism DMWX5CO RN Inactivation of CYP2A6 and CYP2A13 during nicotine metabolism. J Pharmacol Exp Ther. 2006 Jan;316(1):295-303. DMWX5CO RU https://www.ncbi.nlm.nih.gov/pubmed/?term=16188955 DMWX5CO DI DMWX5CO DMWX5CO DN Nicotine DMWX5CO MI DEJVYAZ DMWX5CO MN Cytochrome P450 2A6 (CYP2A6) DMWX5CO MT DME DMWX5CO MA Metabolism DMWX5CO RN CYP2A6- and CYP2A13-catalyzed metabolism of the nicotine delta-5'(1')iminium ion. J Pharmacol Exp Ther. 2012 Nov;343(2):307-15. DMWX5CO RU https://www.ncbi.nlm.nih.gov/pubmed/?term=22869927 DMWX5CO DI DMWX5CO DMWX5CO DN Nicotine DMWX5CO MI DEPKLMQ DMWX5CO MN Cytochrome P450 2B6 (CYP2B6) DMWX5CO MT DME DMWX5CO MA Metabolism DMWX5CO RN Nicotine and 4-(methylnitrosamino)-1-(3-pyridyl)-butanone metabolism by cytochrome P450 2B6. Drug Metab Dispos. 2005 Dec;33(12):1760-4. DMWX5CO RU https://www.ncbi.nlm.nih.gov/pubmed/?term=16174803 DMWX5CO DI DMWX5CO DMWX5CO DN Nicotine DMWX5CO MI DES5XRU DMWX5CO MN Cytochrome P450 2C8 (CYP2C8) DMWX5CO MT DME DMWX5CO MA Metabolism DMWX5CO RN Roles of CYP2A6 and CYP2B6 in nicotine C-oxidation by human liver microsomes. Arch Toxicol. 1999 Mar;73(2):65-70. DMWX5CO RU https://www.ncbi.nlm.nih.gov/pubmed/?term=10350185 DMWX5CO DI DMWX5CO DMWX5CO DN Nicotine DMWX5CO MI DE5IED8 DMWX5CO MN Cytochrome P450 2C9 (CYP2C9) DMWX5CO MT DME DMWX5CO MA Metabolism DMWX5CO RN Roles of CYP2A6 and CYP2B6 in nicotine C-oxidation by human liver microsomes. Arch Toxicol. 1999 Mar;73(2):65-70. DMWX5CO RU https://www.ncbi.nlm.nih.gov/pubmed/?term=10350185 DMWX5CO DI DMWX5CO DMWX5CO DN Nicotine DMWX5CO MI DECB0K3 DMWX5CO MN Cytochrome P450 2D6 (CYP2D6) DMWX5CO MT DME DMWX5CO MA Metabolism DMWX5CO RN Roles of CYP2A6 and CYP2B6 in nicotine C-oxidation by human liver microsomes. Arch Toxicol. 1999 Mar;73(2):65-70. DMWX5CO RU https://www.ncbi.nlm.nih.gov/pubmed/?term=10350185 DMWX5CO DI DMWX5CO DMWX5CO DN Nicotine DMWX5CO MI DEVDYN7 DMWX5CO MN Cytochrome P450 2E1 (CYP2E1) DMWX5CO MT DME DMWX5CO MA Metabolism DMWX5CO RN Effects of nicotine on cytochrome P450 2A6 and 2E1 activities. Br J Clin Pharmacol. 2010 Feb;69(2):152-9. DMWX5CO RU https://www.ncbi.nlm.nih.gov/pubmed/?term=20233178 DMWX5CO DI DMWX5CO DMWX5CO DN Nicotine DMWX5CO MI DE4LYSA DMWX5CO MN Cytochrome P450 3A4 (CYP3A4) DMWX5CO MT DME DMWX5CO MA Metabolism DMWX5CO RN Roles of CYP2A6 and CYP2B6 in nicotine C-oxidation by human liver microsomes. Arch Toxicol. 1999 Mar;73(2):65-70. DMWX5CO RU https://www.ncbi.nlm.nih.gov/pubmed/?term=10350185 DMWX5CO DI DMWX5CO DMWX5CO DN Nicotine DMWX5CO MI DEGTFWK DMWX5CO MN Mephenytoin 4-hydroxylase (CYP2C19) DMWX5CO MT DME DMWX5CO MA Metabolism DMWX5CO RN Roles of CYP2A6 and CYP2B6 in nicotine C-oxidation by human liver microsomes. Arch Toxicol. 1999 Mar;73(2):65-70. DMWX5CO RU https://www.ncbi.nlm.nih.gov/pubmed/?term=10350185 DMWX5CO DI DMWX5CO DMWX5CO DN Nicotine DMWX5CO MI DE4AMLP DMWX5CO MN Nicotinate dehydrogenase (nicA) DMWX5CO MT DME DMWX5CO MA Metabolism DMWX5CO RN Optimization of a nicotine degrading enzyme for potential use in treatment of nicotine addiction. BMC Biotechnol. 2019 Aug 2;19(1):56. DMWX5CO RU https://pubmed.ncbi.nlm.nih.gov/31375100 DMWX5CO DI DMWX5CO DMWX5CO DN Nicotine DMWX5CO MI TTJSZTB DMWX5CO MN Nicotinic acetylcholine receptor (nAChR) DMWX5CO MT DTT DMWX5CO MA Antagonist DMWX5CO RN Atypical antipsychotics as noncompetitive inhibitors of alpha4beta2 and alpha7 neuronal nicotinic receptors. Neuropharmacology. 2009 Aug;57(2):183-91. DMWX5CO RU https://pubmed.ncbi.nlm.nih.gov/19481556 DMWX5CO DI DMWX5CO DMWX5CO DN Nicotine DMWX5CO MI DEYGVN4 DMWX5CO MN UDP-glucuronosyltransferase 1A1 (UGT1A1) DMWX5CO MT DME DMWX5CO MA Metabolism DMWX5CO RN Liquid chromatography-tandem mass spectrometry method for measurement of nicotine N-glucuronide: a marker for human UGT2B10 inhibition. J Pharm Biomed Anal. 2011 Jul 15;55(5):964-71. DMWX5CO RU https://www.ncbi.nlm.nih.gov/pubmed/?term=21497036 DMSVOZT DI DMSVOZT DMSVOZT DN Nifedipine DMSVOZT MI DE4OGUF DMSVOZT MN Cytochrome P450 102A1 (cyp102) DMSVOZT MT DME DMSVOZT MA Metabolism DMSVOZT RN Wild-type CYP102A1 as a biocatalyst: turnover of drugs usually metabolised by human liver enzymes. J Biol Inorg Chem. 2007 Mar;12(3):313-23. DMSVOZT RU https://pubmed.ncbi.nlm.nih.gov/17235582 DMSVOZT DI DMSVOZT DMSVOZT DN Nifedipine DMSVOZT MI DEJGDUW DMSVOZT MN Cytochrome P450 1A2 (CYP1A2) DMSVOZT MT DME DMSVOZT MA Metabolism DMSVOZT RN Inhibition of human cytochrome P450 enzymes by 1,4-dihydropyridine calcium antagonists: prediction of in vivo drug-drug interactions. Eur J Clin Pharmacol. 2000 Feb-Mar;55(11-12):843-52. DMSVOZT RU https://www.ncbi.nlm.nih.gov/pubmed/?term=10805063 DMSVOZT DI DMSVOZT DMSVOZT DN Nifedipine DMSVOZT MI DECB0K3 DMSVOZT MN Cytochrome P450 2D6 (CYP2D6) DMSVOZT MT DME DMSVOZT MA Metabolism DMSVOZT RN Molecular basis of polymorphic drug metabolism. J Mol Med (Berl). 1995 Nov;73(11):539-53. DMSVOZT RU https://www.ncbi.nlm.nih.gov/pubmed/?term=8751138 DMSVOZT DI DMSVOZT DMSVOZT DN Nifedipine DMSVOZT MI DE4LYSA DMSVOZT MN Cytochrome P450 3A4 (CYP3A4) DMSVOZT MT DME DMSVOZT MA Metabolism DMSVOZT RN Metabolic interactions of selected antimalarial and non-antimalarial drugs with the major pathway (3-hydroxylation) of quinine in human liver microsomes. Br J Clin Pharmacol. 1997 Nov;44(5):505-11. DMSVOZT RU https://www.ncbi.nlm.nih.gov/pubmed/?term=9384469 DMSVOZT DI DMSVOZT DMSVOZT DN Nifedipine DMSVOZT MI DEIBDNY DMSVOZT MN Cytochrome P450 3A5 (CYP3A5) DMSVOZT MT DME DMSVOZT MA Metabolism DMSVOZT RN In vitro metabolism of midazolam, triazolam, nifedipine, and testosterone by human liver microsomes and recombinant cytochromes p450: role of cyp3a4 and cyp3a5. Drug Metab Dispos. 2003 Jul;31(7):938-44. DMSVOZT RU https://www.ncbi.nlm.nih.gov/pubmed/?term=12814972 DMSVOZT DI DMSVOZT DMSVOZT DN Nifedipine DMSVOZT MI DTUGYRD DMSVOZT MN P-glycoprotein 1 (ABCB1) DMSVOZT MT DTP DMSVOZT MA Substrate DMSVOZT RN Mammalian drug efflux transporters of the ATP binding cassette (ABC) family in multidrug resistance: A review of the past decade. Cancer Lett. 2016 Jan 1;370(1):153-64. DMSVOZT RU http://www.ncbi.nlm.nih.gov/pubmed/26499806 DMSVOZT DI DMSVOZT DMSVOZT DN Nifedipine DMSVOZT MI TTXHYV6 DMSVOZT MN Voltage-gated L-type calcium channel (L-CaC) DMSVOZT MT DTT DMSVOZT MA Modulator DMSVOZT RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. DMSVOZT RU https://www.fda.gov/ DMJ3I1Q DI DMJ3I1Q DMJ3I1Q DN Niflumic acid DMJ3I1Q MI TTVKILB DMJ3I1Q MN Prostaglandin G/H synthase 2 (COX-2) DMJ3I1Q MT DTT DMJ3I1Q MA Inhibitor DMJ3I1Q RN Rat ovulation, implantation and decidualization are severely compromised by COX-2 inhibitors. Front Biosci. 2007 May 1;12:3333-42. DMJ3I1Q RU https://pubmed.ncbi.nlm.nih.gov/17485303 DMJ3I1Q DI DMJ3I1Q DMJ3I1Q DN Niflumic acid DMJ3I1Q MI DEYGVN4 DMJ3I1Q MN UDP-glucuronosyltransferase 1A1 (UGT1A1) DMJ3I1Q MT DME DMJ3I1Q MA Metabolism DMJ3I1Q RN Identification of human UDP-glucuronosyltransferase responsible for the glucuronidation of niflumic acid in human liver. Pharm Res. 2006 Jul;23(7):1502-8. DMJ3I1Q RU https://www.ncbi.nlm.nih.gov/pubmed/?term=16783480 DMSQLZJ DI DMSQLZJ DMSQLZJ DN Nifurtimox DMSQLZJ MI DTI7UX6 DMSQLZJ MN Breast cancer resistance protein (ABCG2) DMSQLZJ MT DTP DMSQLZJ MA Substrate DMSQLZJ RN The transport of nifurtimox, an anti-trypanosomal drug, in an in vitro model of the human blood-brain barrier: evidence for involvement of breast cancer resistance protein. Brain Res. 2012 Feb 3;1436:111-21. DMSQLZJ RU https://doi.org/10.1016/j.brainres.2011.11.053 DM7HXWT DI DM7HXWT DM7HXWT DN Nilotinib DM7HXWT MI DTI7UX6 DM7HXWT MN Breast cancer resistance protein (ABCG2) DM7HXWT MT DTP DM7HXWT MA Substrate DM7HXWT RN Interaction of nilotinib, dasatinib and bosutinib with ABCB1 and ABCG2: implications for altered anti-cancer effects and pharmacological properties. Br J Pharmacol. 2009 Oct;158(4):1153-64. DM7HXWT RU http://www.ncbi.nlm.nih.gov/pubmed/19785662 DM7HXWT DI DM7HXWT DM7HXWT DN Nilotinib DM7HXWT MI DES5XRU DM7HXWT MN Cytochrome P450 2C8 (CYP2C8) DM7HXWT MT DME DM7HXWT MA Metabolism DM7HXWT RN Role of cytochrome P450 2C8 in drug metabolism and interactions. Pharmacol Rev. 2016 Jan;68(1):168-241. DM7HXWT RU https://www.ncbi.nlm.nih.gov/pubmed/?term=26721703 DM7HXWT DI DM7HXWT DM7HXWT DN Nilotinib DM7HXWT MI DE4LYSA DM7HXWT MN Cytochrome P450 3A4 (CYP3A4) DM7HXWT MT DME DM7HXWT MA Metabolism DM7HXWT RN Drug interactions with the tyrosine kinase inhibitors imatinib, dasatinib, and nilotinib. Blood. 2011 Feb 24;117(8):e75-87. DM7HXWT RU https://www.ncbi.nlm.nih.gov/pubmed/?term=20810928 DM7HXWT DI DM7HXWT DM7HXWT DN Nilotinib DM7HXWT MI TTS7G69 DM7HXWT MN Fusion protein Bcr-Abl (Bcr-Abl) DM7HXWT MT DTT DM7HXWT MA Modulator DM7HXWT RN 2007 FDA drug approvals: a year of flux. Nat Rev Drug Discov. 2008 Feb;7(2):107-9. DM7HXWT RU https://pubmed.ncbi.nlm.nih.gov/18246607 DM7HXWT DI DM7HXWT DM7HXWT DN Nilotinib DM7HXWT MI DTFI42L DM7HXWT MN Multidrug resistance-associated protein 2 (ABCC2) DM7HXWT MT DTP DM7HXWT MA Substrate DM7HXWT RN Interaction of nilotinib, dasatinib and bosutinib with ABCB1 and ABCG2: implications for altered anti-cancer effects and pharmacological properties. Br J Pharmacol. 2009 Oct;158(4):1153-64. DM7HXWT RU http://www.ncbi.nlm.nih.gov/pubmed/19785662 DM7HXWT DI DM7HXWT DM7HXWT DN Nilotinib DM7HXWT MI DT3D8F0 DM7HXWT MN Organic anion transporting polypeptide 1B1 (SLCO1B1) DM7HXWT MT DTP DM7HXWT MA Substrate DM7HXWT RN Contribution of OATP1B1 and OATP1B3 to the disposition of sorafenib and sorafenib-glucuronide. Clin Cancer Res. 2013 Mar 15;19(6):1458-66. DM7HXWT RU http://www.ncbi.nlm.nih.gov/pubmed/23340295 DM7HXWT DI DM7HXWT DM7HXWT DN Nilotinib DM7HXWT MI DT9C1TS DM7HXWT MN Organic anion transporting polypeptide 1B3 (SLCO1B3) DM7HXWT MT DTP DM7HXWT MA Substrate DM7HXWT RN Contribution of OATP1B1 and OATP1B3 to the disposition of sorafenib and sorafenib-glucuronide. Clin Cancer Res. 2013 Mar 15;19(6):1458-66. DM7HXWT RU http://www.ncbi.nlm.nih.gov/pubmed/23340295 DM7HXWT DI DM7HXWT DM7HXWT DN Nilotinib DM7HXWT MI DTUGYRD DM7HXWT MN P-glycoprotein 1 (ABCB1) DM7HXWT MT DTP DM7HXWT MA Substrate DM7HXWT RN KEGG: new perspectives on genomes, pathways, diseases and drugs. Nucleic Acids Res. 2017 Jan 4;45(D1):D353-D361. (dg:DG01665) DM7HXWT RU https://www.kegg.jp/dbget-bin/www_bget?dg:DG01665 DMFN07X DI DMFN07X DMFN07X DN Nilutamide DMFN07X MI TTS64P2 DMFN07X MN Androgen receptor (AR) DMFN07X MT DTT DMFN07X MA Antagonist DMFN07X RN CX3CR1 is expressed by prostate epithelial cells and androgens regulate the levels of CX3CL1/fractalkine in the bone marrow: potential role in prostate cancer bone tropism. Cancer Res. 2008 Mar 15;68(6):1715-22. DMFN07X RU https://pubmed.ncbi.nlm.nih.gov/18339851 DMFN07X DI DMFN07X DMFN07X DN Nilutamide DMFN07X MI DEGTFWK DMFN07X MN Mephenytoin 4-hydroxylase (CYP2C19) DMFN07X MT DME DMFN07X MA Metabolism DMFN07X RN Nilutamide inhibits mephenytoin 4-hydroxylation in untreated male rats and in human liver microsomes. Xenobiotica. 1991 Dec;21(12):1559-70. DMFN07X RU https://www.ncbi.nlm.nih.gov/pubmed/?term=1785203 DMFN07X DI DMFN07X DMFN07X DN Nilutamide DMFN07X MI DE3N2FM DMFN07X MN NADPH-cytochrome P450 reductase (CPR) DMFN07X MT DME DMFN07X MA Metabolism DMFN07X RN Generation of free radicals during the reductive metabolism of nilutamide by lung microsomes: possible role in the development of lung lesions in patients treated with this anti-androgen. Biochem Pharmacol. 1992 Feb 4;43(3):654-7. DMFN07X RU https://www.ncbi.nlm.nih.gov/pubmed/?term=1311586 DMQ0RKZ DI DMQ0RKZ DMQ0RKZ DN Nimodipine DMQ0RKZ MI TT5HONZ DMQ0RKZ MN Calcium channel unspecific (CaC) DMQ0RKZ MT DTT DMQ0RKZ MA Blocker DMQ0RKZ RN Influence of bupropion and calcium channel antagonists on the nicotine-induced memory-related response of mice in the elevated plus maze. Pharmacol Rep. 2009 Mar-Apr;61(2):236-44. DMQ0RKZ RU https://pubmed.ncbi.nlm.nih.gov/19443934 DMQ0RKZ DI DMQ0RKZ DMQ0RKZ DN Nimodipine DMQ0RKZ MI DE4LYSA DMQ0RKZ MN Cytochrome P450 3A4 (CYP3A4) DMQ0RKZ MT DME DMQ0RKZ MA Metabolism DMQ0RKZ RN Summary of information on human CYP enzymes: human P450 metabolism data. Drug Metab Rev. 2002 Feb-May;34(1-2):83-448. DMQ0RKZ RU https://www.ncbi.nlm.nih.gov/pubmed/?term=11996015 DMQ0RKZ DI DMQ0RKZ DMQ0RKZ DN Nimodipine DMQ0RKZ MI DEIBDNY DMQ0RKZ MN Cytochrome P450 3A5 (CYP3A5) DMQ0RKZ MT DME DMQ0RKZ MA Metabolism DMQ0RKZ RN Enzyme kinetics and inhibition of nimodipine metabolism in human liver microsomes. Acta Pharmacol Sin. 2000 Aug;21(8):690-4. DMQ0RKZ RU https://www.ncbi.nlm.nih.gov/pubmed/?term=11501176 DMQ0RKZ DI DMQ0RKZ DMQ0RKZ DN Nimodipine DMQ0RKZ MI DTUGYRD DMQ0RKZ MN P-glycoprotein 1 (ABCB1) DMQ0RKZ MT DTP DMQ0RKZ MA Substrate DMQ0RKZ RN Human intestinal transporter database: QSAR modeling and virtual profiling of drug uptake, efflux and interactions. Pharm Res. 2013 Apr;30(4):996-1007. DMQ0RKZ RU https://doi.org/10.1007/s11095-012-0935-x DMA65ER DI DMA65ER DMA65ER DN Nipradilol DMA65ER MI TTMXGCW DMA65ER MN Adrenergic receptor beta-3 (ADRB3) DMA65ER MT DTT DMA65ER MA Modulator DMA65ER RN Actions of nipradilol (K-351), a new alpha- and beta-adrenoceptor blocker, on the rabbit portal vein. Jpn J Pharmacol. 1984 Aug;35(4):359-69. DMA65ER RU https://pubmed.ncbi.nlm.nih.gov/6150128 DMLPSWQ DI DMLPSWQ DMLPSWQ DN Niraparib Tosylate DMLPSWQ MI TTVDSZ0 DMLPSWQ MN Poly [ADP-ribose] polymerase 1 (PARP1) DMLPSWQ MT DTT DMLPSWQ MA Modulator DMLPSWQ RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. DMLPSWQ RU https://www.fda.gov/ DM7ISKJ DI DM7ISKJ DM7ISKJ DN Nisoldipine DM7ISKJ MI TT5HONZ DM7ISKJ MN Calcium channel unspecific (CaC) DM7ISKJ MT DTT DM7ISKJ MA Blocker DM7ISKJ RN RT-PCR and pharmacological analysis of L-and T-type calcium channels in rat carotid body. Adv Exp Med Biol. 2009;648:105-12. DM7ISKJ RU https://pubmed.ncbi.nlm.nih.gov/19536471 DM7ISKJ DI DM7ISKJ DM7ISKJ DN Nisoldipine DM7ISKJ MI DE4LYSA DM7ISKJ MN Cytochrome P450 3A4 (CYP3A4) DM7ISKJ MT DME DM7ISKJ MA Metabolism DM7ISKJ RN Summary of information on human CYP enzymes: human P450 metabolism data. Drug Metab Rev. 2002 Feb-May;34(1-2):83-448. DM7ISKJ RU https://www.ncbi.nlm.nih.gov/pubmed/?term=11996015 DM7ISKJ DI DM7ISKJ DM7ISKJ DN Nisoldipine DM7ISKJ MI DEIBDNY DM7ISKJ MN Cytochrome P450 3A5 (CYP3A5) DM7ISKJ MT DME DM7ISKJ MA Metabolism DM7ISKJ RN Drug Interactions Flockhart Table DM7ISKJ RU https://drug-interactions.medicine.iu.edu/Main-Table.aspx DM7ISKJ DI DM7ISKJ DM7ISKJ DN Nisoldipine DM7ISKJ MI DERD86B DM7ISKJ MN Cytochrome P450 3A7 (CYP3A7) DM7ISKJ MT DME DM7ISKJ MA Metabolism DM7ISKJ RN Drug Interactions Flockhart Table DM7ISKJ RU https://drug-interactions.medicine.iu.edu/Main-Table.aspx DM7ISKJ DI DM7ISKJ DM7ISKJ DN Nisoldipine DM7ISKJ MI DTUGYRD DM7ISKJ MN P-glycoprotein 1 (ABCB1) DM7ISKJ MT DTP DM7ISKJ MA Substrate DM7ISKJ RN Mammalian drug efflux transporters of the ATP binding cassette (ABC) family in multidrug resistance: A review of the past decade. Cancer Lett. 2016 Jan 1;370(1):153-64. DM7ISKJ RU http://www.ncbi.nlm.nih.gov/pubmed/26499806 DMOWLVG DI DMOWLVG DMOWLVG DN Nitazoxanide DMOWLVG MI TT0F5P8 DMOWLVG MN Cryptosporidium Pyruvate:ferredoxin oxidoreductase (Crypto CpPNO) DMOWLVG MT DTT DMOWLVG MA Modulator DMOWLVG RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. DMOWLVG RU https://www.fda.gov/ DMVS9WQ DI DMVS9WQ DMVS9WQ DN Nitisinone DMVS9WQ MI TT8DSFC DMVS9WQ MN Hydroxyphenylpyruvate dioxygenase (HPD) DMVS9WQ MT DTT DMVS9WQ MA Inhibitor DMVS9WQ RN Experience of nitisinone for the pharmacological treatment of hereditary tyrosinaemia type 1. Expert Opin Pharmacother. 2008 May;9(7):1229-36. DMVS9WQ RU https://pubmed.ncbi.nlm.nih.gov/18422479 DMEGIQ6 DI DMEGIQ6 DMEGIQ6 DN Nitrazepam DMEGIQ6 MI DE4LYSA DMEGIQ6 MN Cytochrome P450 3A4 (CYP3A4) DMEGIQ6 MT DME DMEGIQ6 MA Metabolism DMEGIQ6 RN Prediction of metabolic clearance using fresh human hepatocytes: comparison with cryopreserved hepatocytes and hepatic microsomes for five benzodiazepines. Xenobiotica. 2008 Apr;38(4):353-67. DMEGIQ6 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=18340561 DMEGIQ6 DI DMEGIQ6 DMEGIQ6 DN Nitrazepam DMEGIQ6 MI TT1MPAY DMEGIQ6 MN GABA(A) receptor alpha-1 (GABRA1) DMEGIQ6 MT DTT DMEGIQ6 MA Antagonist DMEGIQ6 RN DrugBank: a knowledgebase for drugs, drug actions and drug targets. Nucleic Acids Res. 2008 Jan;36(Database issue):D901-6. DMEGIQ6 RU https://pubmed.ncbi.nlm.nih.gov/18048412 DMEGIQ6 DI DMEGIQ6 DMEGIQ6 DN Nitrazepam DMEGIQ6 MI DEAVXGM DMEGIQ6 MN Nitroreductase (NTR) DMEGIQ6 MT DME DMEGIQ6 MA Metabolism DMEGIQ6 RN Reduction of nitrazepam by Clostridium leptum, a nitroreductase-producing bacterium isolated from the human intestinal tract. Clin Infect Dis. 1997 Sep;25 Suppl 2:S121-2. DMEGIQ6 RU https://pubmed.ncbi.nlm.nih.gov/9310649 DMEGIQ6 DI DMEGIQ6 DMEGIQ6 DN Nitrazepam DMEGIQ6 MI DEGV7K0 DMEGIQ6 MN Nitroreductase (NTR) DMEGIQ6 MT DME DMEGIQ6 MA Metabolism DMEGIQ6 RN Distinct genetic and functional traits of human intestinal Prevotella copri strains are associated with different habitual diets. Cell Host Microbe. 2019 Mar 13;25(3):444-453.e3. DMEGIQ6 RU https://pubmed.ncbi.nlm.nih.gov/30799264 DMEGIQ6 DI DMEGIQ6 DMEGIQ6 DN Nitrazepam DMEGIQ6 MI DE0K82S DMEGIQ6 MN Nitroreductase (NTR) DMEGIQ6 MT DME DMEGIQ6 MA Metabolism DMEGIQ6 RN Purification and characterization of wild-type and mutant "classical" nitroreductases of Salmonella typhimurium. L33R mutation greatly diminishes binding of FMN to the nitroreductase of S. typhimurium. J Biol Chem. 1998 Sep 11;273(37):23922-8. DMEGIQ6 RU https://pubmed.ncbi.nlm.nih.gov/9727006 DMEGIQ6 DI DMEGIQ6 DMEGIQ6 DN Nitrazepam DMEGIQ6 MI DEDPI65 DMEGIQ6 MN Oxygen-insensitive NADPH nitroreductase A (nfsA) DMEGIQ6 MT DME DMEGIQ6 MA Metabolism DMEGIQ6 RN Biochemical characterization of NfsA, the Escherichia coli major nitroreductase exhibiting a high amino acid sequence homology to Frp, a Vibrio harveyi flavin oxidoreductase. J Bacteriol. 1996 Aug;178(15):4508-14. DMEGIQ6 RU https://pubmed.ncbi.nlm.nih.gov/8755878 DMEGIQ6 DI DMEGIQ6 DMEGIQ6 DN Nitrazepam DMEGIQ6 MI DEX5D46 DMEGIQ6 MN Oxygen-insensitive NADPH nitroreductase A (nfsA) DMEGIQ6 MT DME DMEGIQ6 MA Metabolism DMEGIQ6 RN Identification and characterization of SnrA, an inducible oxygen-insensitive nitroreductase in Salmonella enterica serovar Typhimurium TA1535. Mutat Res. 2002 Oct 31;508(1-2):59-70. DMEGIQ6 RU https://pubmed.ncbi.nlm.nih.gov/12379462 DMEGIQ6 DI DMEGIQ6 DMEGIQ6 DN Nitrazepam DMEGIQ6 MI DE0QLUZ DMEGIQ6 MN Oxygen-insensitive NADPH nitroreductase B (nfsB) DMEGIQ6 MT DME DMEGIQ6 MA Metabolism DMEGIQ6 RN Conversion of NfsB, a minor Escherichia coli nitroreductase, to a flavin reductase similar in biochemical properties to FRase I, the major flavin reductase in Vibrio fischeri, by a single amino acid substitution. J Bacteriol. 1996 Aug;178(15):4731-3. DMEGIQ6 RU https://pubmed.ncbi.nlm.nih.gov/8755909 DM21C09 DI DM21C09 DM21C09 DN Nitrendipine DM21C09 MI DE4LYSA DM21C09 MN Cytochrome P450 3A4 (CYP3A4) DM21C09 MT DME DM21C09 MA Metabolism DM21C09 RN Summary of information on human CYP enzymes: human P450 metabolism data. Drug Metab Rev. 2002 Feb-May;34(1-2):83-448. DM21C09 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=11996015 DM21C09 DI DM21C09 DM21C09 DN Nitrendipine DM21C09 MI DEIBDNY DM21C09 MN Cytochrome P450 3A5 (CYP3A5) DM21C09 MT DME DM21C09 MA Metabolism DM21C09 RN Drug Interactions Flockhart Table DM21C09 RU https://drug-interactions.medicine.iu.edu/Main-Table.aspx DM21C09 DI DM21C09 DM21C09 DN Nitrendipine DM21C09 MI DERD86B DM21C09 MN Cytochrome P450 3A7 (CYP3A7) DM21C09 MT DME DM21C09 MA Metabolism DM21C09 RN Drug Interactions Flockhart Table DM21C09 RU https://drug-interactions.medicine.iu.edu/Main-Table.aspx DM21C09 DI DM21C09 DM21C09 DN Nitrendipine DM21C09 MI DTUGYRD DM21C09 MN P-glycoprotein 1 (ABCB1) DM21C09 MT DTP DM21C09 MA Substrate DM21C09 RN Mammalian drug efflux transporters of the ATP binding cassette (ABC) family in multidrug resistance: A review of the past decade. Cancer Lett. 2016 Jan 1;370(1):153-64. DM21C09 RU http://www.ncbi.nlm.nih.gov/pubmed/26499806 DM21C09 DI DM21C09 DM21C09 DN Nitrendipine DM21C09 MI TTFK1JQ DM21C09 MN Voltage-gated calcium channel alpha-2/delta-1 (CACNA2D1) DM21C09 MT DTT DM21C09 MA Blocker DM21C09 RN Sulfobutyl ether-alkyl ether mixed cyclodextrin derivatives with enhanced inclusion ability. J Pharm Sci. 2009 Dec;98(12):4769-80. DM21C09 RU https://pubmed.ncbi.nlm.nih.gov/19408308 DM1RBYG DI DM1RBYG DM1RBYG DN Nitric Oxide DM1RBYG MI DTW7AE3 DM1RBYG MN Alanine/serine/cysteine/threonine transporter 2 (SLC1A5) DM1RBYG MT DTP DM1RBYG MA Substrate DM1RBYG RN Functional regulation of Na+-dependent neutral amino acid transporter ASCT2 by S-nitrosothiols and nitric oxide in Caco-2 cells. FEBS Lett. 2005 Apr 25;579(11):2499-506. DM1RBYG RU http://www.ncbi.nlm.nih.gov/pubmed/15848195 DM1RBYG DI DM1RBYG DM1RBYG DN Nitric Oxide DM1RBYG MI TT6HPVC DM1RBYG MN Guanylate cyclase (GC) DM1RBYG MT DTT DM1RBYG MA Stimulator DM1RBYG RN Nitric oxide and nitric oxide synthase isoforms in the normal, hypertrophic, and failing heart. Mol Cell Biochem. 2010 Jan;333(1-2):191-201. DM1RBYG RU https://pubmed.ncbi.nlm.nih.gov/19618122 DM1RBYG DI DM1RBYG DM1RBYG DN Nitric Oxide DM1RBYG MI TT23PYC DM1RBYG MN Soluble guanylate cyclase (GCS) DM1RBYG MT DTT DM1RBYG MA Stimulator DM1RBYG RN Nitric oxide and nitrovasodilators: similarities, differences, and interactions. Am J Cardiol. 1996 May 30;77(13):2C-7C. DM1RBYG RU https://pubmed.ncbi.nlm.nih.gov/8638522 DM7PQIK DI DM7PQIK DM7PQIK DN Nitrofurantoin DM7PQIK MI TTS1W4A DM7PQIK MN Bacterial Deoxyribonucleic acid (Bact DNA) DM7PQIK MT DTT DM7PQIK MA Breaker DM7PQIK RN On the nature of the adaptive response induced by mitomycin C in Vibrio cholerae OGAWA 154 cells. Biochem Biophys Res Commun. 1996 Mar 27;220(3):509-14. DM7PQIK RU https://pubmed.ncbi.nlm.nih.gov/8607796 DM7PQIK DI DM7PQIK DM7PQIK DN Nitrofurantoin DM7PQIK MI DTI7UX6 DM7PQIK MN Breast cancer resistance protein (ABCG2) DM7PQIK MT DTP DM7PQIK MA Substrate DM7PQIK RN The breast cancer resistance protein (BCRP/ABCG2) affects pharmacokinetics, hepatobiliary excretion, and milk secretion of the antibiotic nitrofurantoin. Mol Pharmacol. 2005 May;67(5):1758-64. DM7PQIK RU http://www.ncbi.nlm.nih.gov/pubmed/15709111 DM7PQIK DI DM7PQIK DM7PQIK DN Nitrofurantoin DM7PQIK MI DE3N2FM DM7PQIK MN NADPH-cytochrome P450 reductase (CPR) DM7PQIK MT DME DM7PQIK MA Metabolism DM7PQIK RN Role of cytochrome P450 reductase in nitrofurantoin-induced redox cycling and cytotoxicity. Free Radic Biol Med. 2008 Mar 15;44(6):1169-79. DM7PQIK RU https://www.ncbi.nlm.nih.gov/pubmed/?term=18206659 DM7PQIK DI DM7PQIK DM7PQIK DN Nitrofurantoin DM7PQIK MI DE21PLI DM7PQIK MN NADPH-dependent nitroreductase (nfrA1) DM7PQIK MT DME DM7PQIK MA Metabolism DM7PQIK RN Conversion of NfsA, the major Escherichia coli nitroreductase, to a flavin reductase with an activity similar to that of Frp, a flavin reductase in Vibrio harveyi, by a single amino acid substitution. J Bacteriol. 1998 Jan;180(2):422-5. DM7PQIK RU https://pubmed.ncbi.nlm.nih.gov/9440535 DM7PQIK DI DM7PQIK DM7PQIK DN Nitrofurantoin DM7PQIK MI DE82GV7 DM7PQIK MN NADPH-dependent oxidoreductase (nfrA) DM7PQIK MT DME DM7PQIK MA Metabolism DM7PQIK RN Reduction of polynitroaromatic compounds: the bacterial nitroreductases. FEMS Microbiol Rev. 2008 May;32(3):474-500. DM7PQIK RU https://pubmed.ncbi.nlm.nih.gov/18355273 DM7PQIK DI DM7PQIK DM7PQIK DN Nitrofurantoin DM7PQIK MI DEAVXGM DM7PQIK MN Nitroreductase (NTR) DM7PQIK MT DME DM7PQIK MA Metabolism DM7PQIK RN Isolation of nitrofurantoin-resistant mutants of nitroreductase-producing Clostridium sp. strains from the human intestinal tract. Antimicrob Agents Chemother. 1998 May;42(5):1121-6. DM7PQIK RU https://pubmed.ncbi.nlm.nih.gov/9593138 DM7PQIK DI DM7PQIK DM7PQIK DN Nitrofurantoin DM7PQIK MI DE7XBKW DM7PQIK MN Nitroreductase (NTR) DM7PQIK MT DME DM7PQIK MA Metabolism DM7PQIK RN Isolation of nitrofurantoin-resistant mutants of nitroreductase-producing Clostridium sp. strains from the human intestinal tract. Antimicrob Agents Chemother. 1998 May;42(5):1121-6. DM7PQIK RU https://pubmed.ncbi.nlm.nih.gov/9593138 DM7PQIK DI DM7PQIK DM7PQIK DN Nitrofurantoin DM7PQIK MI DEP7ECA DM7PQIK MN Nitroreductase (NTR) DM7PQIK MT DME DM7PQIK MA Metabolism DM7PQIK RN Isolation of nitrofurantoin-resistant mutants of nitroreductase-producing Clostridium sp. strains from the human intestinal tract. Antimicrob Agents Chemother. 1998 May;42(5):1121-6. DM7PQIK RU https://pubmed.ncbi.nlm.nih.gov/9593138 DM7PQIK DI DM7PQIK DM7PQIK DN Nitrofurantoin DM7PQIK MI DEH3ABM DM7PQIK MN Nitroreductase (NTR) DM7PQIK MT DME DM7PQIK MA Metabolism DM7PQIK RN Isolation of nitrofurantoin-resistant mutants of nitroreductase-producing Clostridium sp. strains from the human intestinal tract. Antimicrob Agents Chemother. 1998 May;42(5):1121-6. DM7PQIK RU https://pubmed.ncbi.nlm.nih.gov/9593138 DM7PQIK DI DM7PQIK DM7PQIK DN Nitrofurantoin DM7PQIK MI DE3U2Y6 DM7PQIK MN Nitroreductase (NTR) DM7PQIK MT DME DM7PQIK MA Metabolism DM7PQIK RN Mechanism of metronidazole-resistance by isolates of nitroreductase-producing Enterococcus gallinarum and Enterococcus casseliflavus from the human intestinal tract. FEMS Microbiol Lett. 2003 Aug 29;225(2):195-200. DM7PQIK RU https://pubmed.ncbi.nlm.nih.gov/12951241 DM7PQIK DI DM7PQIK DM7PQIK DN Nitrofurantoin DM7PQIK MI DEUW4J0 DM7PQIK MN Nitroreductase (NTR) DM7PQIK MT DME DM7PQIK MA Metabolism DM7PQIK RN Mechanism of metronidazole-resistance by isolates of nitroreductase-producing Enterococcus gallinarum and Enterococcus casseliflavus from the human intestinal tract. FEMS Microbiol Lett. 2003 Aug 29;225(2):195-200. DM7PQIK RU https://pubmed.ncbi.nlm.nih.gov/12951241 DM7PQIK DI DM7PQIK DM7PQIK DN Nitrofurantoin DM7PQIK MI DE5LYXF DM7PQIK MN Nitroreductase (NTR) DM7PQIK MT DME DM7PQIK MA Metabolism DM7PQIK RN Biotransformation of 1-nitropyrene in intestinal anaerobic bacteria. Microbiol Immunol. 1982;26(11):993-1005. DM7PQIK RU https://pubmed.ncbi.nlm.nih.gov/7167066 DMSM2KE DI DMSM2KE DMSM2KE DN Nitrofurazone DMSM2KE MI TTOVFH2 DMSM2KE MN Bacterial 30S ribosomal RNA (Bact 30S rRNA) DMSM2KE MT DTT DMSM2KE MA Inhibitor DMSM2KE RN The antibiotic Furvina targets the P-site of 30S ribosomal subunits and inhibits translation initiation displaying start codon bias. Nucleic Acids Res. 2012 Nov 1;40(20):10366-74. DMSM2KE RU https://pubmed.ncbi.nlm.nih.gov/22941660 DMSM2KE DI DMSM2KE DMSM2KE DN Nitrofurazone DMSM2KE MI DECB0K3 DMSM2KE MN Cytochrome P450 2D6 (CYP2D6) DMSM2KE MT DME DMSM2KE MA Metabolism DMSM2KE RN Nefazodone pharmacokinetics in depressed children and adolescents. J Am Acad Child Adolesc Psychiatry. 2000 Aug;39(8):1008-16. DMSM2KE RU https://www.ncbi.nlm.nih.gov/pubmed/?term=10939229 DMSM2KE DI DMSM2KE DMSM2KE DN Nitrofurazone DMSM2KE MI DE21PLI DMSM2KE MN NADPH-dependent nitroreductase (nfrA1) DMSM2KE MT DME DMSM2KE MA Metabolism DMSM2KE RN Conversion of NfsA, the major Escherichia coli nitroreductase, to a flavin reductase with an activity similar to that of Frp, a flavin reductase in Vibrio harveyi, by a single amino acid substitution. J Bacteriol. 1998 Jan;180(2):422-5. DMSM2KE RU https://pubmed.ncbi.nlm.nih.gov/9440535 DMSM2KE DI DMSM2KE DMSM2KE DN Nitrofurazone DMSM2KE MI DE82GV7 DMSM2KE MN NADPH-dependent oxidoreductase (nfrA) DMSM2KE MT DME DMSM2KE MA Metabolism DMSM2KE RN Reduction of polynitroaromatic compounds: the bacterial nitroreductases. FEMS Microbiol Rev. 2008 May;32(3):474-500. DMSM2KE RU https://pubmed.ncbi.nlm.nih.gov/18355273 DMSM2KE DI DMSM2KE DMSM2KE DN Nitrofurazone DMSM2KE MI DE3U2Y6 DMSM2KE MN Nitroreductase (NTR) DMSM2KE MT DME DMSM2KE MA Metabolism DMSM2KE RN Mechanism of metronidazole-resistance by isolates of nitroreductase-producing Enterococcus gallinarum and Enterococcus casseliflavus from the human intestinal tract. FEMS Microbiol Lett. 2003 Aug 29;225(2):195-200. DMSM2KE RU https://pubmed.ncbi.nlm.nih.gov/12951241 DMSM2KE DI DMSM2KE DMSM2KE DN Nitrofurazone DMSM2KE MI DEUW4J0 DMSM2KE MN Nitroreductase (NTR) DMSM2KE MT DME DMSM2KE MA Metabolism DMSM2KE RN Mechanism of metronidazole-resistance by isolates of nitroreductase-producing Enterococcus gallinarum and Enterococcus casseliflavus from the human intestinal tract. FEMS Microbiol Lett. 2003 Aug 29;225(2):195-200. DMSM2KE RU https://pubmed.ncbi.nlm.nih.gov/12951241 DMSM2KE DI DMSM2KE DMSM2KE DN Nitrofurazone DMSM2KE MI DEDPI65 DMSM2KE MN Oxygen-insensitive NADPH nitroreductase A (nfsA) DMSM2KE MT DME DMSM2KE MA Metabolism DMSM2KE RN Biochemical characterization of NfsA, the Escherichia coli major nitroreductase exhibiting a high amino acid sequence homology to Frp, a Vibrio harveyi flavin oxidoreductase. J Bacteriol. 1996 Aug;178(15):4508-14. DMSM2KE RU https://pubmed.ncbi.nlm.nih.gov/8755878 DMSM2KE DI DMSM2KE DMSM2KE DN Nitrofurazone DMSM2KE MI DE0QLUZ DMSM2KE MN Oxygen-insensitive NADPH nitroreductase B (nfsB) DMSM2KE MT DME DMSM2KE MA Metabolism DMSM2KE RN Conversion of NfsB, a minor Escherichia coli nitroreductase, to a flavin reductase similar in biochemical properties to FRase I, the major flavin reductase in Vibrio fischeri, by a single amino acid substitution. J Bacteriol. 1996 Aug;178(15):4731-3. DMSM2KE RU https://pubmed.ncbi.nlm.nih.gov/8755909 DMQ2491 DI DMQ2491 DMQ2491 DN Nitroglycerin DMQ2491 MI TTGKNB4 DMQ2491 MN Epidermal growth factor receptor (EGFR) DMQ2491 MT DTT DMQ2491 MA Activator DMQ2491 RN Emerging drugs for diabetic foot ulcers. Expert Opin Emerg Drugs. 2006 Nov;11(4):709-24. DMQ2491 RU https://pubmed.ncbi.nlm.nih.gov/17064227 DMQ2491 DI DMQ2491 DMQ2491 DN Nitroglycerin DMQ2491 MI TT23PYC DMQ2491 MN Soluble guanylate cyclase (GCS) DMQ2491 MT DTT DMQ2491 MA Modulator DMQ2491 RN Activators of soluble guanylate cyclase for the treatment of male erectile dysfunction. Int J Impot Res. 2002 Feb;14(1):8-14. DMQ2491 RU https://pubmed.ncbi.nlm.nih.gov/11896472 DMM765C DI DMM765C DMM765C DN Nitroprusside DMM765C MI TTC9IZL DMM765C MN Inositol 1,4,5-trisphosphate receptor (ITPR) DMM765C MT DTT DMM765C MA Antagonist DMM765C RN Prostacyclin and sodium nitroprusside inhibit the activity of the platelet inositol 1,4,5-trisphosphate receptor and promote its phosphorylation. J Biol Chem. 1996 Mar 8;271(10):5545-51. DMM765C RU https://pubmed.ncbi.nlm.nih.gov/8621413 DMLUA2J DI DMLUA2J DMLUA2J DN Nitroprusside DMLUA2J MI DEAH3PE DMLUA2J MN S-(hydroxymethyl)glutathione dehydrogenase (adh) DMLUA2J MT DME DMLUA2J MA Metabolism DMLUA2J RN Nitrosative stress response in Vibrio cholerae: role of S-nitrosoglutathione reductase. Appl Biochem Biotechnol. 2017 Jul;182(3):871-884. DMLUA2J RU https://pubmed.ncbi.nlm.nih.gov/28000045 DMTHWBI DI DMTHWBI DMTHWBI DN Nitrous oxide DMTHWBI MI TT9IK2Z DMTHWBI MN N-methyl-D-aspartate receptor (NMDAR) DMTHWBI MT DTT DMTHWBI MA Antagonist DMTHWBI RN Anaesthetic drugs: linking molecular actions to clinical effects. Curr Pharm Des. 2006;12(28):3665-79. DMTHWBI RU https://pubmed.ncbi.nlm.nih.gov/17073666 DMAB9QE DI DMAB9QE DMAB9QE DN Nivolumab DMAB9QE MI TTNBFWK DMAB9QE MN Programmed cell death protein 1 (PD-1) DMAB9QE MT DTT DMAB9QE MA Modulator DMAB9QE RN 2014 FDA drug approvals. Nat Rev Drug Discov. 2015 Feb;14(2):77-81. DMAB9QE RU https://pubmed.ncbi.nlm.nih.gov/25633781 DMGFV3Z DI DMGFV3Z DMGFV3Z DN Nizatidine DMGFV3Z MI TTQHJ1K DMGFV3Z MN Histamine H2 receptor (H2R) DMGFV3Z MT DTT DMGFV3Z MA Antagonist DMGFV3Z RN Does the use of nizatidine, as a pro-kinetic agent, improve gastric emptying in patients post-oesophagectomy J Gastrointest Surg. 2009 Mar;13(3):432-7. DMGFV3Z RU https://pubmed.ncbi.nlm.nih.gov/18979143 DMGFV3Z DI DMGFV3Z DMGFV3Z DN Nizatidine DMGFV3Z MI DTT79CX DMGFV3Z MN Organic cation transporter 1 (SLC22A1) DMGFV3Z MT DTP DMGFV3Z MA Substrate DMGFV3Z RN Identification of novel substrates and structure-activity relationship of cellular uptake mediated by human organic cation transporters 1 and 2. J Med Chem. 2013 Sep 26;56(18):7232-42. DMGFV3Z RU http://www.ncbi.nlm.nih.gov/pubmed/23984907 DMGFV3Z DI DMGFV3Z DMGFV3Z DN Nizatidine DMGFV3Z MI DTUGYRD DMGFV3Z MN P-glycoprotein 1 (ABCB1) DMGFV3Z MT DTP DMGFV3Z MA Substrate DMGFV3Z RN DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. (ID: DB00585) DMGFV3Z RU https://www.drugbank.ca/drugs/DB00585 DMRJ7D1 DI DMRJ7D1 DMRJ7D1 DN Nomegestrol acetate DMRJ7D1 MI TTZAYWL DMRJ7D1 MN Estrogen receptor (ESR) DMRJ7D1 MT DTT DMRJ7D1 MA Modulator DMRJ7D1 RN Regulation of rat uterine steroid receptors by nomegestrol acetate, a new 19-nor-progesterone derivative. J Pharmacol Exp Ther. 1989 Feb;248(2):758-61. DMRJ7D1 RU https://pubmed.ncbi.nlm.nih.gov/2918478 DMOUC09 DI DMOUC09 DMOUC09 DN Norepinephrine DMOUC09 MI TTR6W5O DMOUC09 MN Adrenergic receptor beta-1 (ADRB1) DMOUC09 MT DTT DMOUC09 MA Stimulator DMOUC09 RN Impact of exogenous beta-adrenergic receptor stimulation on hepatosplanchnic oxygen kinetics and metabolic activity in septic shock. Crit Care Med. 1999 Feb;27(2):325-31. DMOUC09 RU https://pubmed.ncbi.nlm.nih.gov/10075057 DMOUC09 DI DMOUC09 DMOUC09 DN Norepinephrine DMOUC09 MI DTT79CX DMOUC09 MN Organic cation transporter 1 (SLC22A1) DMOUC09 MT DTP DMOUC09 MA Substrate DMOUC09 RN Organic cation transporters and their pharmacokinetic and pharmacodynamic consequences. Drug Metab Pharmacokinet. 2008;23(4):243-53. DMOUC09 RU https://doi.org/10.2133/dmpk.23.243 DMOUC09 DI DMOUC09 DMOUC09 DN Norepinephrine DMOUC09 MI DT9IDPW DMOUC09 MN Organic cation transporter 2 (SLC22A2) DMOUC09 MT DTP DMOUC09 MA Substrate DMOUC09 RN Differential pharmacological in vitro properties of organic cation transporters and regional distribution in rat brain. Neuropharmacology. 2006 Jun;50(8):941-52. DMOUC09 RU http://www.ncbi.nlm.nih.gov/pubmed/16581093 DMOUC09 DI DMOUC09 DMOUC09 DN Norepinephrine DMOUC09 MI DT6201N DMOUC09 MN Organic cation transporter 3 (SLC22A3) DMOUC09 MT DTP DMOUC09 MA Substrate DMOUC09 RN Differential pharmacological in vitro properties of organic cation transporters and regional distribution in rat brain. Neuropharmacology. 2006 Jun;50(8):941-52. DMOUC09 RU http://www.ncbi.nlm.nih.gov/pubmed/16581093 DMOUC09 DI DMOUC09 DMOUC09 DN Norepinephrine DMOUC09 MI DTE8R17 DMOUC09 MN Sodium- and chloride-dependent glycine transporter 2 (SLC6A5) DMOUC09 MT DTP DMOUC09 MA Substrate DMOUC09 RN SLC6A2 Gene (Protein Coding). DMOUC09 RU https://www.genecards.org/cgi-bin/carddisp.pl?gene=SLC6A2 DMOUC09 DI DMOUC09 DMOUC09 DN Norepinephrine DMOUC09 MI DT9JBVI DMOUC09 MN Sodium-dependent noradrenaline transporter (SLC6A2) DMOUC09 MT DTP DMOUC09 MA Substrate DMOUC09 RN Chronic depolarization stimulates norepinephrine transporter expression via catecholamines. J Neurochem. 2006 May;97(4):1044-51. DMOUC09 RU http://www.ncbi.nlm.nih.gov/pubmed/16573647 DMOUC09 DI DMOUC09 DMOUC09 DN Norepinephrine DMOUC09 MI DTM953D DMOUC09 MN Vesicular amine transporter 1 (SLC18A1) DMOUC09 MT DTP DMOUC09 MA Substrate DMOUC09 RN SLC18: Vesicular neurotransmitter transporters for monoamines and acetylcholine. Mol Aspects Med. 2013 Apr-Jun;34(2-3):360-72. DMOUC09 RU http://www.ncbi.nlm.nih.gov/pubmed/23506877 DMOUC09 DI DMOUC09 DMOUC09 DN Norepinephrine DMOUC09 MI DTT7VPB DMOUC09 MN Vesicular amine transporter 2 (SLC18A2) DMOUC09 MT DTP DMOUC09 MA Substrate DMOUC09 RN SLC18: Vesicular neurotransmitter transporters for monoamines and acetylcholine. Mol Aspects Med. 2013 Apr-Jun;34(2-3):360-72. DMOUC09 RU http://www.ncbi.nlm.nih.gov/pubmed/23506877 DMTY169 DI DMTY169 DMTY169 DN Norethindrone DMTY169 MI TTUV8G9 DMTY169 MN Progesterone receptor (PGR) DMTY169 MT DTT DMTY169 MA Agonist DMTY169 RN Progesterone receptor ligand binding pocket flexibility: crystal structures of the norethindrone and mometasone furoate complexes. J Med Chem. 2004 Jun 17;47(13):3381-7. DMTY169 RU https://pubmed.ncbi.nlm.nih.gov/15189034 DMDGCQP DI DMDGCQP DMDGCQP DN Norethindrone acetate DMDGCQP MI DEAJN47 DMDGCQP MN Aldo-keto reductase 1C4 (AKR1C4) DMDGCQP MT DME DMDGCQP MA Metabolism DMDGCQP RN Hormonal properties of norethisterone, 7alpha-methyl-norethisterone and their derivatives. J Steroid Biochem Mol Biol. 2000 Nov 15;74(4):213-22. DMDGCQP RU https://www.ncbi.nlm.nih.gov/pubmed/?term=11162927 DMDGCQP DI DMDGCQP DMDGCQP DN Norethindrone acetate DMDGCQP MI DEVON3M DMDGCQP MN Aldo-keto reductase 1D1 (AKR1D1) DMDGCQP MT DME DMDGCQP MA Metabolism DMDGCQP RN Hormonal properties of norethisterone, 7alpha-methyl-norethisterone and their derivatives. J Steroid Biochem Mol Biol. 2000 Nov 15;74(4):213-22. DMDGCQP RU https://www.ncbi.nlm.nih.gov/pubmed/?term=11162927 DMDGCQP DI DMDGCQP DMDGCQP DN Norethindrone acetate DMDGCQP MI DEN0GVQ DMDGCQP MN Beta-HSD adrenal and gonadal type (HSD3B2) DMDGCQP MT DME DMDGCQP MA Metabolism DMDGCQP RN Hormonal properties of norethisterone, 7alpha-methyl-norethisterone and their derivatives. J Steroid Biochem Mol Biol. 2000 Nov 15;74(4):213-22. DMDGCQP RU https://www.ncbi.nlm.nih.gov/pubmed/?term=11162927 DMDGCQP DI DMDGCQP DMDGCQP DN Norethindrone acetate DMDGCQP MI DEJGDUW DMDGCQP MN Cytochrome P450 1A2 (CYP1A2) DMDGCQP MT DME DMDGCQP MA Metabolism DMDGCQP RN Identification of the human cytochrome P450 enzymes involved in the in vitro biotransformation of lynestrenol and norethindrone. J Steroid Biochem Mol Biol. 2008 May;110(1-2):56-66. DMDGCQP RU https://www.ncbi.nlm.nih.gov/pubmed/?term=18356043 DMDGCQP DI DMDGCQP DMDGCQP DN Norethindrone acetate DMDGCQP MI DEJVYAZ DMDGCQP MN Cytochrome P450 2A6 (CYP2A6) DMDGCQP MT DME DMDGCQP MA Metabolism DMDGCQP RN Identification of the human cytochrome P450 enzymes involved in the in vitro biotransformation of lynestrenol and norethindrone. J Steroid Biochem Mol Biol. 2008 May;110(1-2):56-66. DMDGCQP RU https://www.ncbi.nlm.nih.gov/pubmed/?term=18356043 DMDGCQP DI DMDGCQP DMDGCQP DN Norethindrone acetate DMDGCQP MI DE4LYSA DMDGCQP MN Cytochrome P450 3A4 (CYP3A4) DMDGCQP MT DME DMDGCQP MA Metabolism DMDGCQP RN Identification of the human cytochrome P450 enzymes involved in the in vitro biotransformation of lynestrenol and norethindrone. J Steroid Biochem Mol Biol. 2008 May;110(1-2):56-66. DMDGCQP RU https://www.ncbi.nlm.nih.gov/pubmed/?term=18356043 DMDGCQP DI DMDGCQP DMDGCQP DN Norethindrone acetate DMDGCQP MI DEIBDNY DMDGCQP MN Cytochrome P450 3A5 (CYP3A5) DMDGCQP MT DME DMDGCQP MA Metabolism DMDGCQP RN The interaction between St John's wort and an oral contraceptive. Clin Pharmacol Ther. 2003 Dec;74(6):525-35. DMDGCQP RU https://www.ncbi.nlm.nih.gov/pubmed/?term=14663455 DMDGCQP DI DMDGCQP DMDGCQP DN Norethindrone acetate DMDGCQP MI DERD86B DMDGCQP MN Cytochrome P450 3A7 (CYP3A7) DMDGCQP MT DME DMDGCQP MA Metabolism DMDGCQP RN The interaction between St John's wort and an oral contraceptive. Clin Pharmacol Ther. 2003 Dec;74(6):525-35. DMDGCQP RU https://www.ncbi.nlm.nih.gov/pubmed/?term=14663455 DMDGCQP DI DMDGCQP DMDGCQP DN Norethindrone acetate DMDGCQP MI DEGTFWK DMDGCQP MN Mephenytoin 4-hydroxylase (CYP2C19) DMDGCQP MT DME DMDGCQP MA Metabolism DMDGCQP RN Drug Interactions Flockhart Table DMDGCQP RU https://drug-interactions.medicine.iu.edu/Main-Table.aspx DMIZ6W2 DI DMIZ6W2 DMIZ6W2 DN Norfloxacin DMIZ6W2 MI TTN6J5F DMIZ6W2 MN Bacterial DNA gyrase (Bact gyrase) DMIZ6W2 MT DTT DMIZ6W2 MA Modulator DMIZ6W2 RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. DMIZ6W2 RU https://www.fda.gov/ DMIZ6W2 DI DMIZ6W2 DMIZ6W2 DN Norfloxacin DMIZ6W2 MI DTI7UX6 DMIZ6W2 MN Breast cancer resistance protein (ABCG2) DMIZ6W2 MT DTP DMIZ6W2 MA Substrate DMIZ6W2 RN Breast cancer resistance protein (BCRP/ABCG2) transports fluoroquinolone antibiotics and affects their oral availability, pharmacokinetics, and milk secretion. Drug Metab Dispos. 2006 Apr;34(4):690-5. DMIZ6W2 RU http://www.ncbi.nlm.nih.gov/pubmed/16434544 DMIZ6W2 DI DMIZ6W2 DMIZ6W2 DN Norfloxacin DMIZ6W2 MI DEJGDUW DMIZ6W2 MN Cytochrome P450 1A2 (CYP1A2) DMIZ6W2 MT DME DMIZ6W2 MA Metabolism DMIZ6W2 RN Clinically significant psychotropic drug-drug interactions in the primary care setting. Curr Psychiatry Rep. 2012 Aug;14(4):376-90. DMIZ6W2 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=22707017 DMIZ6W2 DI DMIZ6W2 DMIZ6W2 DN Norfloxacin DMIZ6W2 MI DTE2B1D DMIZ6W2 MN Organic anion transporting polypeptide 1A2 (SLCO1A2) DMIZ6W2 MT DTP DMIZ6W2 MA Substrate DMIZ6W2 RN Identification of influx transporter for the quinolone antibacterial agent levofloxacin. Mol Pharm. 2007 Jan-Feb;4(1):85-94. DMIZ6W2 RU http://www.ncbi.nlm.nih.gov/pubmed/17274666 DMIZ6W2 DI DMIZ6W2 DMIZ6W2 DN Norfloxacin DMIZ6W2 MI DTUGYRD DMIZ6W2 MN P-glycoprotein 1 (ABCB1) DMIZ6W2 MT DTP DMIZ6W2 MA Substrate DMIZ6W2 RN Human intestinal transporter database: QSAR modeling and virtual profiling of drug uptake, efflux and interactions. Pharm Res. 2013 Apr;30(4):996-1007. DMIZ6W2 RU https://doi.org/10.1007/s11095-012-0935-x DMYP4XC DI DMYP4XC DMYP4XC DN Norgestimate DMYP4XC MI DE4LYSA DMYP4XC MN Cytochrome P450 3A4 (CYP3A4) DMYP4XC MT DME DMYP4XC MA Metabolism DMYP4XC RN Metabolite identification, reaction phenotyping, and retrospective drug-drug interaction predictions of 17-deacetylnorgestimate, the active component of the oral contraceptive norgestimate. Drug Metab Dispos. 2017 Jun;45(6):676-685. DMYP4XC RU https://www.ncbi.nlm.nih.gov/pubmed/?term=28283499 DMYP4XC DI DMYP4XC DMYP4XC DN Norgestimate DMYP4XC MI TTUV8G9 DMYP4XC MN Progesterone receptor (PGR) DMYP4XC MT DTT DMYP4XC MA Agonist DMYP4XC RN Pharmacological profile of progestins. Maturitas. 2008 Sep-Oct;61(1-2):151-7. DMYP4XC RU https://pubmed.ncbi.nlm.nih.gov/19434887 DM4KDYJ DI DM4KDYJ DM4KDYJ DN Nortriptyline DM4KDYJ MI DEJGDUW DM4KDYJ MN Cytochrome P450 1A2 (CYP1A2) DM4KDYJ MT DME DM4KDYJ MA Metabolism DM4KDYJ RN Hydroxylation and demethylation of the tricyclic antidepressant nortriptyline by cDNA-expressed human cytochrome P-450 isozymes. Drug Metab Dispos. 1997 Jun;25(6):740-4. DM4KDYJ RU https://www.ncbi.nlm.nih.gov/pubmed/?term=9193876 DM4KDYJ DI DM4KDYJ DM4KDYJ DN Nortriptyline DM4KDYJ MI DECB0K3 DM4KDYJ MN Cytochrome P450 2D6 (CYP2D6) DM4KDYJ MT DME DM4KDYJ MA Metabolism DM4KDYJ RN A study on CYP2C19 and CYP2D6 polymorphic effects on pharmacokinetics and pharmacodynamics of amitriptyline in healthy Koreans. Clin Transl Sci. 2017 Mar;10(2):93-101. DM4KDYJ RU https://www.ncbi.nlm.nih.gov/pubmed/?term=28296334 DM4KDYJ DI DM4KDYJ DM4KDYJ DN Nortriptyline DM4KDYJ MI DE4LYSA DM4KDYJ MN Cytochrome P450 3A4 (CYP3A4) DM4KDYJ MT DME DM4KDYJ MA Metabolism DM4KDYJ RN Cytochrome P-450 activities in human and rat brain microsomes. Brain Res. 2000 Feb 14;855(2):235-43. DM4KDYJ RU https://www.ncbi.nlm.nih.gov/pubmed/?term=10677595 DM4KDYJ DI DM4KDYJ DM4KDYJ DN Nortriptyline DM4KDYJ MI DEIBDNY DM4KDYJ MN Cytochrome P450 3A5 (CYP3A5) DM4KDYJ MT DME DM4KDYJ MA Metabolism DM4KDYJ RN Bioactivation of the tricyclic antidepressant amitriptyline and its metabolite nortriptyline to arene oxide intermediates in human liver microsomes and recombinant P450s. Chem Biol Interact. 2008 May 9;173(1):59-67. DM4KDYJ RU https://www.ncbi.nlm.nih.gov/pubmed/?term=18359012 DM4KDYJ DI DM4KDYJ DM4KDYJ DN Nortriptyline DM4KDYJ MI DEGTFWK DM4KDYJ MN Mephenytoin 4-hydroxylase (CYP2C19) DM4KDYJ MT DME DM4KDYJ MA Metabolism DM4KDYJ RN In vivo age-related changes in hepatic drug-oxidizing capacity in humans. J Clin Pharm Ther. 1998 Aug;23(4):247-55. DM4KDYJ RU https://www.ncbi.nlm.nih.gov/pubmed/?term=9867310 DM4KDYJ DI DM4KDYJ DM4KDYJ DN Nortriptyline DM4KDYJ MI DE073H6 DM4KDYJ MN Prostaglandin G/H synthase 1 (COX-1) DM4KDYJ MT DME DM4KDYJ MA Metabolism DM4KDYJ RN Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. DM4KDYJ RU https://www.ncbi.nlm.nih.gov/pubmed/?term=19515014 DM4KDYJ DI DM4KDYJ DM4KDYJ DN Nortriptyline DM4KDYJ MI TT3ROYC DM4KDYJ MN Serotonin transporter (SERT) DM4KDYJ MT DTT DM4KDYJ MA Modulator DM4KDYJ RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. DM4KDYJ RU https://www.fda.gov/ DMRFWGK DI DMRFWGK DMRFWGK DN Novobiocin DMRFWGK MI TT0IHXV DMRFWGK MN DNA topoisomerase II (TOP2) DMRFWGK MT DTT DMRFWGK MA Inhibitor DMRFWGK RN Transcriptional responses of Bacillus subtillis and thuringiensis to antibiotics and anti-tumour drugs. Int J Mol Med. 2009 Jan;23(1):33-9. DMRFWGK RU https://pubmed.ncbi.nlm.nih.gov/19082504 DM6ZPLQ DI DM6ZPLQ DM6ZPLQ DN Novolimus DM6ZPLQ MI TTCJG29 DM6ZPLQ MN Serine/threonine-protein kinase mTOR (mTOR) DM6ZPLQ MT DTT DM6ZPLQ MA Inhibitor DM6ZPLQ RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2109). DM6ZPLQ RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2109 DMRSX53 DI DMRSX53 DMRSX53 DN nusinersen DMRSX53 MI TTSVGQ5 DMRSX53 MN SMN1 messenger RNA (SMN1 mRNA) DMRSX53 MT DTT DMRSX53 MA Modulator DMRSX53 RN 2016 FDA drug approvals. Nat Rev Drug Discov. 2017 Feb 2;16(2):73-76. DMRSX53 RU https://www.ncbi.nlm.nih.gov/pubmed/28148938 DM63QS9 DI DM63QS9 DM63QS9 DN Nystatin DM63QS9 MI TTQKWA4 DM63QS9 MN Fungal Cell membrane ergosterol (Fung CME) DM63QS9 MT DTT DM63QS9 MA Modulator DM63QS9 RN Cholesterol and Ergosterol Influence Nystatin Surface Aggregation: Relation to Pore Formation DM63QS9 RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1304795 DM3Q1SM DI DM3Q1SM DM3Q1SM DN Obeticholic acid DM3Q1SM MI DERA3OF DM3Q1SM MN Bile acid-CoA thioesterase (BAAT) DM3Q1SM MT DME DM3Q1SM MA Metabolism DM3Q1SM RN Glycine and taurine conjugation of bile acids by a single enzyme. Molecular cloning and expression of human liver bile acid CoA:amino acid N-acyltransferase. J Biol Chem. 1994 Jul 29;269(30):19375-9. DM3Q1SM RU http://www.jbc.org/content/269/30/19375.full.pdf DM3Q1SM DI DM3Q1SM DM3Q1SM DN Obeticholic acid DM3Q1SM MI TTS4UGC DM3Q1SM MN Farnesoid X-activated receptor (FXR) DM3Q1SM MT DTT DM3Q1SM MA Modulator DM3Q1SM RN 2016 FDA drug approvals. Nat Rev Drug Discov. 2017 Feb 2;16(2):73-76. DM3Q1SM RU https://www.ncbi.nlm.nih.gov/pubmed/28148938 DM3BVAE DI DM3BVAE DM3BVAE DN Obinutuzumab DM3BVAE MI TTUE541 DM3BVAE MN Leukocyte surface antigen Leu-16 (CD20) DM3BVAE MT DTT DM3BVAE RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2628). DM3BVAE RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2628 DMEZ2KH DI DMEZ2KH DMEZ2KH DN Ocrelizumab DMEZ2KH MI TTUE541 DMEZ2KH MN Leukocyte surface antigen Leu-16 (CD20) DMEZ2KH MT DTT DMEZ2KH RN Emerging drugs for rheumatoid arthritis. Expert Opin Emerg Drugs. 2008 Mar;13(1):175-96. DMEZ2KH RU https://pubmed.ncbi.nlm.nih.gov/18321156 DM7AVGW DI DM7AVGW DM7AVGW DN Ocriplasmin DM7AVGW MI TTPJ921 DM7AVGW MN Fibronectin (FN1) DM7AVGW MT DTT DM7AVGW MA Inhibitor DM7AVGW RN Nat Rev Drug Discov. 2013 Feb;12(2):87-90. DM7AVGW RU https://pubmed.ncbi.nlm.nih.gov/23370234 DMHIDCJ DI DMHIDCJ DMHIDCJ DN Octreotide DMHIDCJ MI DTFI42L DMHIDCJ MN Multidrug resistance-associated protein 2 (ABCC2) DMHIDCJ MT DTP DMHIDCJ MA Substrate DMHIDCJ RN P-glycoprotein- and mrp2-mediated octreotide transport in renal proximal tubule. Br J Pharmacol. 2000 Jan;129(2):251-6. DMHIDCJ RU http://www.ncbi.nlm.nih.gov/pubmed/10694230 DMHIDCJ DI DMHIDCJ DMHIDCJ DN Octreotide DMHIDCJ MI TTZ6T9E DMHIDCJ MN Somatostatin receptor type 2 (SSTR2) DMHIDCJ MT DTT DMHIDCJ MA Binder DMHIDCJ RN Versatile conjugation of octreotide to dendrimers by cycloaddition ("click") chemistry to yield high-affinity multivalent cyclic Peptide dendrimers. Bioconjug Chem. 2009 Jul;20(7):1323-31. DMHIDCJ RU https://pubmed.ncbi.nlm.nih.gov/19537708 DMZK0FQ DI DMZK0FQ DMZK0FQ DN Oestradiol valerate and dienogest DMZK0FQ MI DE4LYSA DMZK0FQ MN Cytochrome P450 3A4 (CYP3A4) DMZK0FQ MT DME DMZK0FQ MA Metabolism DMZK0FQ RN Progestogens in menopausal hormone therapy. Prz Menopauzalny. 2015 Jun;14(2):134-43. DMZK0FQ RU https://www.ncbi.nlm.nih.gov/pubmed/?term=26327902 DM295PR DI DM295PR DM295PR DN Ofatumumab DM295PR MI TTUE541 DM295PR MN Leukocyte surface antigen Leu-16 (CD20) DM295PR MT DTT DM295PR RN Hughes B: 2009 FDA drug approvals. Nat Rev Drug Discov. 2010 Feb;9(2):89-92. DM295PR RU https://pubmed.ncbi.nlm.nih.gov/20118952 DM0VQN3 DI DM0VQN3 DM0VQN3 DN Ofloxacin DM0VQN3 MI TTN6J5F DM0VQN3 MN Bacterial DNA gyrase (Bact gyrase) DM0VQN3 MT DTT DM0VQN3 MA Modulator DM0VQN3 RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. DM0VQN3 RU https://www.fda.gov/ DM0VQN3 DI DM0VQN3 DM0VQN3 DN Ofloxacin DM0VQN3 MI DTI7UX6 DM0VQN3 MN Breast cancer resistance protein (ABCG2) DM0VQN3 MT DTP DM0VQN3 MA Substrate DM0VQN3 RN Mammalian drug efflux transporters of the ATP binding cassette (ABC) family in multidrug resistance: A review of the past decade. Cancer Lett. 2016 Jan 1;370(1):153-64. DM0VQN3 RU http://www.ncbi.nlm.nih.gov/pubmed/26499806 DMQ4PKA DI DMQ4PKA DMQ4PKA DN Olamufloxacin DMQ4PKA MI DTFI42L DMQ4PKA MN Multidrug resistance-associated protein 2 (ABCC2) DMQ4PKA MT DTP DMQ4PKA MA Substrate DMQ4PKA RN Human intestinal transporter database: QSAR modeling and virtual profiling of drug uptake, efflux and interactions. Pharm Res. 2013 Apr;30(4):996-1007. DMQ4PKA RU https://doi.org/10.1007/s11095-012-0935-x DMPFN6Y DI DMPFN6Y DMPFN6Y DN Olanzapine DMPFN6Y MI DEJGDUW DMPFN6Y MN Cytochrome P450 1A2 (CYP1A2) DMPFN6Y MT DME DMPFN6Y MA Metabolism DMPFN6Y RN Interactions between the cytochrome P450 system and the second-generation antipsychotics. J Psychiatry Neurosci. 2003 Mar;28(2):99-112. DMPFN6Y RU https://www.ncbi.nlm.nih.gov/pubmed/?term=12670127 DMPFN6Y DI DMPFN6Y DMPFN6Y DN Olanzapine DMPFN6Y MI DECB0K3 DMPFN6Y MN Cytochrome P450 2D6 (CYP2D6) DMPFN6Y MT DME DMPFN6Y MA Metabolism DMPFN6Y RN [Olanzapine: pharmacology, pharmacokinetics and therapeutic drug monitoring]. Fortschr Neurol Psychiatr. 2001 Nov;69(11):510-7. DMPFN6Y RU https://www.ncbi.nlm.nih.gov/pubmed/?term=11704898 DMPFN6Y DI DMPFN6Y DMPFN6Y DN Olanzapine DMPFN6Y MI TTEX248 DMPFN6Y MN Dopamine D2 receptor (D2R) DMPFN6Y MT DTT DMPFN6Y MA Agonist DMPFN6Y RN Olanzapine: an updated review of its use in the management of schizophrenia. Drugs. 2001;61(1):111-61. DMPFN6Y RU https://pubmed.ncbi.nlm.nih.gov/11217867 DMPFN6Y DI DMPFN6Y DMPFN6Y DN Olanzapine DMPFN6Y MI DTUGYRD DMPFN6Y MN P-glycoprotein 1 (ABCB1) DMPFN6Y MT DTP DMPFN6Y MA Substrate DMPFN6Y RN Identification of P-glycoprotein substrates and inhibitors among psychoactive compounds--implications for pharmacokinetics of selected substrates. J Pharm Pharmacol. 2004 Aug;56(8):967-75. DMPFN6Y RU http://www.ncbi.nlm.nih.gov/pubmed/15285840 DM0Y49P DI DM0Y49P DM0Y49P DN Olanzapine/fluoxetine combination DM0Y49P MI TT8G3Z7 DM0Y49P MN Serotoninnorepinephrinedopamine reuptake (SNDR) DM0Y49P MT DTT DM0Y49P MA Antagonist DM0Y49P RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015 DM0Y49P RU https://www.accessdata.fda.gov/scripts/cder/drugsatfda/ DM8QB1D DI DM8QB1D DM8QB1D DN Olaparib DM8QB1D MI DE4LYSA DM8QB1D MN Cytochrome P450 3A4 (CYP3A4) DM8QB1D MT DME DM8QB1D MA Metabolism DM8QB1D RN Extent of radiosensitization by the PARP inhibitor olaparib depends on its dose, the radiation dose and the integrity of the homologous recombination pathway of tumor cells. Radiother Oncol. 2015 Sep;116(3):358-65. DM8QB1D RU https://www.ncbi.nlm.nih.gov/pubmed/?term=25981132 DM8QB1D DI DM8QB1D DM8QB1D DN Olaparib DM8QB1D MI DTUGYRD DM8QB1D MN P-glycoprotein 1 (ABCB1) DM8QB1D MT DTP DM8QB1D MA Substrate DM8QB1D RN Overexpressed ABCB1 Induces Olaparib-Taxane Cross-Resistance in Advanced Prostate Cancer. Transl Oncol. 2019 May 7;12(7):871-878. DM8QB1D RU http://www.ncbi.nlm.nih.gov/pubmed/31075528 DM8QB1D DI DM8QB1D DM8QB1D DN Olaparib DM8QB1D MI TTEBCY8 DM8QB1D MN Poly [ADP-ribose] polymerase (PARP) DM8QB1D MT DTT DM8QB1D MA Modulator DM8QB1D RN 2014 FDA drug approvals. Nat Rev Drug Discov. 2015 Feb;14(2):77-81. DM8QB1D RU https://pubmed.ncbi.nlm.nih.gov/25633781 DMNYOIX DI DMNYOIX DMNYOIX DN Olaratumab DMNYOIX MI TT8FYO9 DMNYOIX MN Platelet-derived growth factor receptor alpha (PDGFRA) DMNYOIX MT DTT DMNYOIX MA Modulator DMNYOIX RN A phase I study of olaratumab, an anti-platelet-derived growth factor receptor alpha (PDGFRalpha) monoclonal antibody, in patients with advanced solid tumors. Cancer Chemother Pharmacol. 2014 Mar;73(3):595-604. DMNYOIX RU https://pubmed.ncbi.nlm.nih.gov/24452395 DM6MDCF DI DM6MDCF DM6MDCF DN Oliceridine DM6MDCF MI DECB0K3 DM6MDCF MN Cytochrome P450 2D6 (CYP2D6) DM6MDCF MT DME DM6MDCF MA Metabolism DM6MDCF RN First clinical experience with TRV130: pharmacokinetics and pharmacodynamics in healthy volunteers. J Clin Pharmacol. 2014 Mar;54(3):351-7. DM6MDCF RU https://www.ncbi.nlm.nih.gov/pubmed/?term=24122908 DMWBHRY DI DMWBHRY DMWBHRY DN Olmesartan medoxomil DMWBHRY MI TT8DBY3 DMWBHRY MN Angiotensin II receptor type-1 (AGTR1) DMWBHRY MT DTT DMWBHRY MA Antagonist DMWBHRY RN Mechanism of diastolic stiffening of the failing myocardium and its prevention by angiotensin receptor and calcium channel blockers. J Cardiovasc Pharmacol. 2009 Jul;54(1):47-56. DMWBHRY RU https://pubmed.ncbi.nlm.nih.gov/19528815 DMWBHRY DI DMWBHRY DMWBHRY DN Olmesartan medoxomil DMWBHRY MI DTI7UX6 DMWBHRY MN Breast cancer resistance protein (ABCG2) DMWBHRY MT DTP DMWBHRY MA Substrate DMWBHRY RN KEGG: new perspectives on genomes, pathways, diseases and drugs. Nucleic Acids Res. 2017 Jan 4;45(D1):D353-D361. (dg:DG01913) DMWBHRY RU https://www.kegg.jp/dbget-bin/www_bget?dg:DG01913 DMWBHRY DI DMWBHRY DMWBHRY DN Olmesartan medoxomil DMWBHRY MI DTFI42L DMWBHRY MN Multidrug resistance-associated protein 2 (ABCC2) DMWBHRY MT DTP DMWBHRY MA Substrate DMWBHRY RN Multiple human isoforms of drug transporters contribute to the hepatic and renal transport of olmesartan, a selective antagonist of the angiotensin II AT1-receptor. Drug Metab Dispos. 2007 Dec;35(12):2166-76. DMWBHRY RU http://www.ncbi.nlm.nih.gov/pubmed/17823233 DMWBHRY DI DMWBHRY DMWBHRY DN Olmesartan medoxomil DMWBHRY MI DTCSGPB DMWBHRY MN Multidrug resistance-associated protein 4 (ABCC4) DMWBHRY MT DTP DMWBHRY MA Substrate DMWBHRY RN Multiple human isoforms of drug transporters contribute to the hepatic and renal transport of olmesartan, a selective antagonist of the angiotensin II AT1-receptor. Drug Metab Dispos. 2007 Dec;35(12):2166-76. DMWBHRY RU http://www.ncbi.nlm.nih.gov/pubmed/17823233 DMWBHRY DI DMWBHRY DMWBHRY DN Olmesartan medoxomil DMWBHRY MI DTQ23VB DMWBHRY MN Organic anion transporter 1 (SLC22A6) DMWBHRY MT DTP DMWBHRY MA Substrate DMWBHRY RN Multiple human isoforms of drug transporters contribute to the hepatic and renal transport of olmesartan, a selective antagonist of the angiotensin II AT1-receptor. Drug Metab Dispos. 2007 Dec;35(12):2166-76. DMWBHRY RU http://www.ncbi.nlm.nih.gov/pubmed/17823233 DMWBHRY DI DMWBHRY DMWBHRY DN Olmesartan medoxomil DMWBHRY MI DTVP67E DMWBHRY MN Organic anion transporter 3 (SLC22A8) DMWBHRY MT DTP DMWBHRY MA Substrate DMWBHRY RN Multiple human isoforms of drug transporters contribute to the hepatic and renal transport of olmesartan, a selective antagonist of the angiotensin II AT1-receptor. Drug Metab Dispos. 2007 Dec;35(12):2166-76. DMWBHRY RU http://www.ncbi.nlm.nih.gov/pubmed/17823233 DMWBHRY DI DMWBHRY DMWBHRY DN Olmesartan medoxomil DMWBHRY MI DT3D8F0 DMWBHRY MN Organic anion transporting polypeptide 1B1 (SLCO1B1) DMWBHRY MT DTP DMWBHRY MA Substrate DMWBHRY RN OATP1B1, OATP1B3, and mrp2 are involved in hepatobiliary transport of olmesartan, a novel angiotensin II blocker. Drug Metab Dispos. 2006 May;34(5):862-9. DMWBHRY RU http://www.ncbi.nlm.nih.gov/pubmed/16501004 DMWBHRY DI DMWBHRY DMWBHRY DN Olmesartan medoxomil DMWBHRY MI DT9C1TS DMWBHRY MN Organic anion transporting polypeptide 1B3 (SLCO1B3) DMWBHRY MT DTP DMWBHRY MA Substrate DMWBHRY RN Multiple human isoforms of drug transporters contribute to the hepatic and renal transport of olmesartan, a selective antagonist of the angiotensin II AT1-receptor. Drug Metab Dispos. 2007 Dec;35(12):2166-76. DMWBHRY RU http://www.ncbi.nlm.nih.gov/pubmed/17823233 DMWBHRY DI DMWBHRY DMWBHRY DN Olmesartan medoxomil DMWBHRY MI DTUGYRD DMWBHRY MN P-glycoprotein 1 (ABCB1) DMWBHRY MT DTP DMWBHRY MA Substrate DMWBHRY RN KEGG: new perspectives on genomes, pathways, diseases and drugs. Nucleic Acids Res. 2017 Jan 4;45(D1):D353-D361. (dg:DG01665) DMWBHRY RU https://www.kegg.jp/dbget-bin/www_bget?dg:DG01665 DM62B78 DI DM62B78 DM62B78 DN Olodaterol DM62B78 MI TT2CJVK DM62B78 MN Adrenergic receptor beta-2 (ADRB2) DM62B78 MT DTT DM62B78 MA Modulator DM62B78 RN 2014 FDA drug approvals. Nat Rev Drug Discov. 2015 Feb;14(2):77-81. DM62B78 RU https://pubmed.ncbi.nlm.nih.gov/25633781 DM62B78 DI DM62B78 DM62B78 DN Olodaterol DM62B78 MI DE5IED8 DM62B78 MN Cytochrome P450 2C9 (CYP2C9) DM62B78 MT DME DM62B78 MA Metabolism DM62B78 RN FDA Label of Olodaterol. The 2020 official website of the U.S. Food and Drug Administration. DM62B78 RU https://www.accessdata.fda.gov/drugsatfda_docs/label/2018/203108s006lbl.pdf DMKMWQG DI DMKMWQG DMKMWQG DN Olopatadine DMKMWQG MI DE4LYSA DMKMWQG MN Cytochrome P450 3A4 (CYP3A4) DMKMWQG MT DME DMKMWQG MA Metabolism DMKMWQG RN Effects of olopatadine, a new antiallergic agent, on human liver microsomal cytochrome P450 activities. Drug Metab Dispos. 2002 Dec;30(12):1504-11. DMKMWQG RU https://www.ncbi.nlm.nih.gov/pubmed/?term=12433826 DMKMWQG DI DMKMWQG DMKMWQG DN Olopatadine DMKMWQG MI TTTIBOJ DMKMWQG MN Histamine H1 receptor (H1R) DMKMWQG MT DTT DMKMWQG MA Antagonist DMKMWQG RN Emerging drugs for ocular allergy. Expert Opin Emerg Drugs. 2005 Aug;10(3):505-20. DMKMWQG RU https://pubmed.ncbi.nlm.nih.gov/16083326 DMKMWQG DI DMKMWQG DMKMWQG DN Olopatadine DMKMWQG MI DTUGYRD DMKMWQG MN P-glycoprotein 1 (ABCB1) DMKMWQG MT DTP DMKMWQG MA Substrate DMKMWQG RN Human intestinal transporter database: QSAR modeling and virtual profiling of drug uptake, efflux and interactions. Pharm Res. 2013 Apr;30(4):996-1007. DMKMWQG RU https://doi.org/10.1007/s11095-012-0935-x DMWBQKU DI DMWBQKU DMWBQKU DN Olprinone DMWBQKU MI TTZCG4L DMWBQKU MN Phosphodiesterase 3 (PDE3) DMWBQKU MT DTT DMWBQKU MA Inhibitor DMWBQKU RN Olprinone: a phosphodiesterase III inhibitor with positive inotropic and vasodilator effects. Cardiovasc Drug Rev. 2002 Fall;20(3):163-74. DMWBQKU RU https://pubmed.ncbi.nlm.nih.gov/12397365 DMZW9HA DI DMZW9HA DMZW9HA DN Olsalazine DMZW9HA MI TTPZ7AG DMZW9HA MN Oxidoreductase unspecific (OR) DMZW9HA MT DTT DMZW9HA MA Modulator DMZW9HA RN Reaction mechanism of azoreductases suggests convergent evolution with quinone oxidoreductases. Protein Cell. 2010 Aug;1(8):780-90. DMZW9HA RU https://pubmed.ncbi.nlm.nih.gov/21203919 DMPU2WX DI DMPU2WX DMPU2WX DN Omacetaxine mepesuccinate DMPU2WX MI TTA4FIU DMPU2WX MN Ribosome A (hRA) DMPU2WX MT DTT DMPU2WX MA Modulator DMPU2WX RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015 DMPU2WX RU https://www.accessdata.fda.gov/scripts/cder/drugsatfda/ DMR2J95 DI DMR2J95 DMR2J95 DN Omadacycline DMR2J95 MI TTOVFH2 DMR2J95 MN Bacterial 30S ribosomal RNA (Bact 30S rRNA) DMR2J95 MT DTT DMR2J95 MA Inhibitor DMR2J95 RN Omadacycline Enters the Ring: A New Antimicrobial Contender.Pharmacotherapy. 2018 Dec;38(12):1194-1204. DMR2J95 RU https://pubmed.ncbi.nlm.nih.gov/30290000 DMU5G01 DI DMU5G01 DMU5G01 DN Omadacycline DMU5G01 MI DTUGYRD DMU5G01 MN P-glycoprotein 1 (ABCB1) DMU5G01 MT DTP DMU5G01 MA Substrate DMU5G01 RN DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. (ID: DB12455) DMU5G01 RU https://www.drugbank.ca/drugs/DB12455 DMETVFJ DI DMETVFJ DMETVFJ DN Omalizumab DMETVFJ MI TTDGEC0 DMETVFJ MN Immunoglobulin epsilon Fc receptor gamma (FCERG) DMETVFJ MT DTT DMETVFJ MA Modulator DMETVFJ RN The potential of biologics for the treatment of asthma. Nat Rev Drug Discov. 2012 Dec;11(12):958-72. DMETVFJ RU https://www.ncbi.nlm.nih.gov/pubmed/23197041 DML9TI0 DI DML9TI0 DML9TI0 DN Ombitasvir + paritaprevir + ritonavir DML9TI0 MI TTWXB3E DML9TI0 MN Hepatitis C virus NS3 helicase (HCV NS3) DML9TI0 MT DTT DML9TI0 MA Modulator DML9TI0 RN HCV Drug Resistance Challenges in Japan: The Role of Pre-Existing Variants and Emerging Resistant Strains in Direct Acting Antiviral Therapy DML9TI0 RU https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4632384 DM471KJ DI DM471KJ DM471KJ DN Omeprazole DM471KJ MI DEZMWRE DM471KJ MN Cytochrome P450 2C18 (CYP2C18) DM471KJ MT DME DM471KJ MA Metabolism DM471KJ RN Human CYP2C19 is a major omeprazole 5-hydroxylase, as demonstrated with recombinant cytochrome P450 enzymes. Drug Metab Dispos. 1996 Oct;24(10):1081-7. DM471KJ RU https://www.ncbi.nlm.nih.gov/pubmed/?term=8894508 DM471KJ DI DM471KJ DM471KJ DN Omeprazole DM471KJ MI DES5XRU DM471KJ MN Cytochrome P450 2C8 (CYP2C8) DM471KJ MT DME DM471KJ MA Metabolism DM471KJ RN Human CYP2C19 is a major omeprazole 5-hydroxylase, as demonstrated with recombinant cytochrome P450 enzymes. Drug Metab Dispos. 1996 Oct;24(10):1081-7. DM471KJ RU https://www.ncbi.nlm.nih.gov/pubmed/?term=8894508 DM471KJ DI DM471KJ DM471KJ DN Omeprazole DM471KJ MI DE5IED8 DM471KJ MN Cytochrome P450 2C9 (CYP2C9) DM471KJ MT DME DM471KJ MA Metabolism DM471KJ RN Comparison of inhibitory effects of the proton pump-inhibiting drugs omeprazole, esomeprazole, lansoprazole, pantoprazole, and rabeprazole on human cytochrome P450 activities. Drug Metab Dispos. 2004 Aug;32(8):821-7. DM471KJ RU https://www.ncbi.nlm.nih.gov/pubmed/?term=15258107 DM471KJ DI DM471KJ DM471KJ DN Omeprazole DM471KJ MI DE4LYSA DM471KJ MN Cytochrome P450 3A4 (CYP3A4) DM471KJ MT DME DM471KJ MA Metabolism DM471KJ RN Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. DM471KJ RU https://www.ncbi.nlm.nih.gov/pubmed/?term=19515014 DM471KJ DI DM471KJ DM471KJ DN Omeprazole DM471KJ MI DEIBDNY DM471KJ MN Cytochrome P450 3A5 (CYP3A5) DM471KJ MT DME DM471KJ MA Metabolism DM471KJ RN Impact of intestinal CYP2C19 genotypes on the interaction between tacrolimus and omeprazole, but not lansoprazole, in adult living-donor liver transplant patients. Drug Metab Dispos. 2009 Apr;37(4):821-6. DM471KJ RU https://www.ncbi.nlm.nih.gov/pubmed/?term=19139162 DM471KJ DI DM471KJ DM471KJ DN Omeprazole DM471KJ MI TTLOKXP DM471KJ MN Gastric H(+)/K(+) ATPase (Proton pump) DM471KJ MT DTT DM471KJ MA Modulator DM471KJ RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. DM471KJ RU https://www.fda.gov/ DM471KJ DI DM471KJ DM471KJ DN Omeprazole DM471KJ MI DEGTFWK DM471KJ MN Mephenytoin 4-hydroxylase (CYP2C19) DM471KJ MT DME DM471KJ MA Metabolism DM471KJ RN Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. DM471KJ RU https://www.ncbi.nlm.nih.gov/pubmed/?term=19515014 DM471KJ DI DM471KJ DM471KJ DN Omeprazole DM471KJ MI DTUGYRD DM471KJ MN P-glycoprotein 1 (ABCB1) DM471KJ MT DTP DM471KJ MA Substrate DM471KJ RN A novel screening strategy to identify ABCB1 substrates and inhibitors. Naunyn Schmiedebergs Arch Pharmacol. 2009 Jan;379(1):11-26. DM471KJ RU https://doi.org/10.1007/s00210-008-0345-0 DMOTQ1I DI DMOTQ1I DMOTQ1I DN Ondansetron DMOTQ1I MI TTNXLKE DMOTQ1I MN 5-HT 3 receptor (5HT3R) DMOTQ1I MT DTT DMOTQ1I MA Agonist DMOTQ1I RN Treatment of pruritus in chronic liver disease with the 5-hydroxytryptamine receptor type 3 antagonist ondansetron: a randomized, placebo-controlled, double-blind cross-over trial. Eur J Gastroenterol Hepatol. 1998 Oct;10(10):865-70. DMOTQ1I RU https://pubmed.ncbi.nlm.nih.gov/9831410 DMOTQ1I DI DMOTQ1I DMOTQ1I DN Ondansetron DMOTQ1I MI DEJGDUW DMOTQ1I MN Cytochrome P450 1A2 (CYP1A2) DMOTQ1I MT DME DMOTQ1I MA Metabolism DMOTQ1I RN Effects of serotonin-3 receptor antagonists on cytochrome P450 activities in human liver microsomes. Biol Pharm Bull. 2006 Sep;29(9):1931-5. DMOTQ1I RU https://www.ncbi.nlm.nih.gov/pubmed/?term=16946512 DMOTQ1I DI DMOTQ1I DMOTQ1I DN Ondansetron DMOTQ1I MI DE5IED8 DMOTQ1I MN Cytochrome P450 2C9 (CYP2C9) DMOTQ1I MT DME DMOTQ1I MA Metabolism DMOTQ1I RN Summary of information on human CYP enzymes: human P450 metabolism data. Drug Metab Rev. 2002 Feb-May;34(1-2):83-448. DMOTQ1I RU https://www.ncbi.nlm.nih.gov/pubmed/?term=11996015 DMOTQ1I DI DMOTQ1I DMOTQ1I DN Ondansetron DMOTQ1I MI DECB0K3 DMOTQ1I MN Cytochrome P450 2D6 (CYP2D6) DMOTQ1I MT DME DMOTQ1I MA Metabolism DMOTQ1I RN Cytochrome P450 2D6 metabolism and 5-hydroxytryptamine type 3 receptor antagonists for postoperative nausea and vomiting. Med Sci Monit. 2005 Oct;11(10):RA322-8. DMOTQ1I RU https://www.ncbi.nlm.nih.gov/pubmed/?term=16192915 DMOTQ1I DI DMOTQ1I DMOTQ1I DN Ondansetron DMOTQ1I MI DEVDYN7 DMOTQ1I MN Cytochrome P450 2E1 (CYP2E1) DMOTQ1I MT DME DMOTQ1I MA Metabolism DMOTQ1I RN Characterization of the cytochrome P450 enzymes involved in the in vitro metabolism of dolasetron. Comparison with other indole-containing 5-HT3 antagonists. Drug Metab Dispos. 1996 May;24(5):602-9. DMOTQ1I RU https://www.ncbi.nlm.nih.gov/pubmed/?term=8723743 DMOTQ1I DI DMOTQ1I DMOTQ1I DN Ondansetron DMOTQ1I MI DE4LYSA DMOTQ1I MN Cytochrome P450 3A4 (CYP3A4) DMOTQ1I MT DME DMOTQ1I MA Metabolism DMOTQ1I RN The effect of rifampin on the pharmacokinetics of oral and intravenous ondansetron. Clin Pharmacol Ther. 1999 Apr;65(4):377-81. DMOTQ1I RU https://www.ncbi.nlm.nih.gov/pubmed/?term=10223773 DMOTQ1I DI DMOTQ1I DMOTQ1I DN Ondansetron DMOTQ1I MI DEIBDNY DMOTQ1I MN Cytochrome P450 3A5 (CYP3A5) DMOTQ1I MT DME DMOTQ1I MA Metabolism DMOTQ1I RN Multiple forms of cytochrome P450 are involved in the metabolism of ondansetron in humans. Drug Metab Dispos. 1995 Nov;23(11):1225-30. DMOTQ1I RU https://www.ncbi.nlm.nih.gov/pubmed/?term=8591723 DMOTQ1I DI DMOTQ1I DMOTQ1I DN Ondansetron DMOTQ1I MI DERD86B DMOTQ1I MN Cytochrome P450 3A7 (CYP3A7) DMOTQ1I MT DME DMOTQ1I MA Metabolism DMOTQ1I RN Multiple forms of cytochrome P450 are involved in the metabolism of ondansetron in humans. Drug Metab Dispos. 1995 Nov;23(11):1225-30. DMOTQ1I RU https://www.ncbi.nlm.nih.gov/pubmed/?term=8591723 DMOTQ1I DI DMOTQ1I DMOTQ1I DN Ondansetron DMOTQ1I MI DTUGYRD DMOTQ1I MN P-glycoprotein 1 (ABCB1) DMOTQ1I MT DTP DMOTQ1I MA Substrate DMOTQ1I RN Polymorphisms in human MDR1 (P-glycoprotein): recent advances and clinical relevance. Clin Pharmacol Ther. 2004 Jan;75(1):13-33. DMOTQ1I RU https://doi.org/10.1016/j.clpt.2003.09.012 DMHG57U DI DMHG57U DMHG57U DN OPC-34712 DMHG57U MI TTSQIFT DMHG57U MN 5-HT 1A receptor (HTR1A) DMHG57U MT DTT DMHG57U MA Modulator DMHG57U RN Effects of brexpiprazole, a novel serotonin-dopamine activity modulator, on phencyclidine-induced cognitive deficits in mice: a role for serotonin 5-HT1A receptors.Pharmacol Biochem Behav.2014 Sep;124:245-9. DMHG57U RU https://www.ncbi.nlm.nih.gov/pubmed/24955861 DMHG57U DI DMHG57U DMHG57U DN OPC-34712 DMHG57U MI DECB0K3 DMHG57U MN Cytochrome P450 2D6 (CYP2D6) DMHG57U MT DME DMHG57U MA Metabolism DMHG57U RN Brexpiprazole: first global approval. Drugs. 2015 Sep;75(14):1687-97. DMHG57U RU https://www.ncbi.nlm.nih.gov/pubmed/?term=26310190 DMHG57U DI DMHG57U DMHG57U DN OPC-34712 DMHG57U MI DE4LYSA DMHG57U MN Cytochrome P450 3A4 (CYP3A4) DMHG57U MT DME DMHG57U MA Metabolism DMHG57U RN Brexpiprazole: first global approval. Drugs. 2015 Sep;75(14):1687-97. DMHG57U RU https://www.ncbi.nlm.nih.gov/pubmed/?term=26310190 DMHG57U DI DMHG57U DMHG57U DN OPC-34712 DMHG57U MI TTEX248 DMHG57U MN Dopamine D2 receptor (D2R) DMHG57U MT DTT DMHG57U MA Modulator DMHG57U RN Effects of brexpiprazole, a novel serotonin-dopamine activity modulator, on phencyclidine-induced cognitive deficits in mice: a role for serotonin 5-HT1A receptors.Pharmacol Biochem Behav.2014 Sep;124:245-9. DMHG57U RU https://www.ncbi.nlm.nih.gov/pubmed/24955861 DMHG57U DI DMHG57U DMHG57U DN OPC-34712 DMHG57U MI DT3BA8L DMHG57U MN Sodium-dependent dopamine transporter (SLC6A3) DMHG57U MT DTP DMHG57U MA Substrate DMHG57U RN Brexpiprazole reduces hyperactivity, impulsivity, and risk-preference behavior in mice with dopamine transporter knockdown-a model of mania. Psychopharmacology (Berl). 2017 Mar;234(6):1017-1028. DMHG57U RU http://www.ncbi.nlm.nih.gov/pubmed/28160035 DM1BKA6 DI DM1BKA6 DM1BKA6 DN Opicapone DM1BKA6 MI TTKWFB8 DM1BKA6 MN Catechol-O-methyl-transferase (COMT) DM1BKA6 MT DTT DM1BKA6 MA Inhibitor DM1BKA6 RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health Human Services. 2020 DM1BKA6 RU https://www.accessdata.fda.gov/drugsatfda_docs/label/2020/212489s000lbl.pdf DMPUOXF DI DMPUOXF DMPUOXF DN Opipramol DMPUOXF MI DECB0K3 DMPUOXF MN Cytochrome P450 2D6 (CYP2D6) DMPUOXF MT DME DMPUOXF MA Metabolism DMPUOXF RN Summary of information on human CYP enzymes: human P450 metabolism data. Drug Metab Rev. 2002 Feb-May;34(1-2):83-448. DMPUOXF RU https://www.ncbi.nlm.nih.gov/pubmed/?term=11996015 DMTSRI6 DI DMTSRI6 DMTSRI6 DN Oprelvekin DMTSRI6 MI TTZPLJS DMTSRI6 MN Interleukin 11 receptor alpha (IL11RA) DMTSRI6 MT DTT DMTSRI6 MA Binder DMTSRI6 RN Oprelvekin: a review of its pharmacology and therapeutic potential in chemotherapy-induced thrombocytopenia. BioDrugs. 1998 Aug;10(2):159-71. DMTSRI6 RU https://pubmed.ncbi.nlm.nih.gov/18020592 DM28D05 DI DM28D05 DM28D05 DN Oritavancin DM28D05 MI TT4ILYC DM28D05 MN Bacterial Dihydropteroate synthetase (Bact folP) DM28D05 MT DTT DM28D05 MA Inhibitor DM28D05 RN Emerging drugs for bacterial urinary tract infections. Expert Opin Emerg Drugs. 2005 May;10(2):275-98. DM28D05 RU https://pubmed.ncbi.nlm.nih.gov/15934867 DMRJSP8 DI DMRJSP8 DMRJSP8 DN Orlistat DMRJSP8 MI TT6OEDT DMRJSP8 MN Cannabinoid receptor 1 (CB1) DMRJSP8 MT DTT DMRJSP8 MA Inhibitor DMRJSP8 RN Tetrahydrolipstatin analogues as modulators of endocannabinoid 2-arachidonoylglycerol metabolism. J Med Chem. 2008 Nov 13;51(21):6970-9. DMRJSP8 RU https://pubmed.ncbi.nlm.nih.gov/18831576 DMRJSP8 DI DMRJSP8 DMRJSP8 DN Orlistat DMRJSP8 MI TTXMY0J DMRJSP8 MN Pancreatic triacylglycerol lipase (PNLIP) DMRJSP8 MT DTT DMRJSP8 MA Modulator DMRJSP8 RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. DMRJSP8 RU https://www.fda.gov/ DM6QHDJ DI DM6QHDJ DM6QHDJ DN Ornidazole DM6QHDJ MI DE4LYSA DM6QHDJ MN Cytochrome P450 3A4 (CYP3A4) DM6QHDJ MT DME DM6QHDJ MA Metabolism DM6QHDJ RN Effect of ketoconazole on the pharmacokinetics of ornidazole--a possible role of p-glycoprotein and CYP3A. Drug Metabol Drug Interact. 2006;22(1):67-77. DM6QHDJ RU https://www.ncbi.nlm.nih.gov/pubmed/?term=17152348 DM6QHDJ DI DM6QHDJ DM6QHDJ DN Ornidazole DM6QHDJ MI DEIBDNY DM6QHDJ MN Cytochrome P450 3A5 (CYP3A5) DM6QHDJ MT DME DM6QHDJ MA Metabolism DM6QHDJ RN Effect of ketoconazole on the pharmacokinetics of ornidazole--a possible role of p-glycoprotein and CYP3A. Drug Metabol Drug Interact. 2006;22(1):67-77. DM6QHDJ RU https://www.ncbi.nlm.nih.gov/pubmed/?term=17152348 DM6QHDJ DI DM6QHDJ DM6QHDJ DN Ornidazole DM6QHDJ MI DERD86B DM6QHDJ MN Cytochrome P450 3A7 (CYP3A7) DM6QHDJ MT DME DM6QHDJ MA Metabolism DM6QHDJ RN Effect of ketoconazole on the pharmacokinetics of ornidazole--a possible role of p-glycoprotein and CYP3A. Drug Metabol Drug Interact. 2006;22(1):67-77. DM6QHDJ RU https://www.ncbi.nlm.nih.gov/pubmed/?term=17152348 DM6QHDJ DI DM6QHDJ DM6QHDJ DN Ornidazole DM6QHDJ MI DE90ZBW DM6QHDJ MN Flavin adenine dinucleotide dehydrogenase (fadd) DM6QHDJ MT DME DM6QHDJ MA Metabolism DM6QHDJ RN Reduction of azo dyes and nitroaromatic compounds by bacterial enzymes from the human intestinal tract. Environ Health Perspect. 1995 Jun;103 Suppl 5:17-9. DM6QHDJ RU https://pubmed.ncbi.nlm.nih.gov/8565901 DM6QHDJ DI DM6QHDJ DM6QHDJ DN Ornidazole DM6QHDJ MI DEXG57F DM6QHDJ MN Flavin adenine dinucleotide dehydrogenase (fadd) DM6QHDJ MT DME DM6QHDJ MA Metabolism DM6QHDJ RN Reduction of azo dyes and nitroaromatic compounds by bacterial enzymes from the human intestinal tract. Environ Health Perspect. 1995 Jun;103 Suppl 5:17-9. DM6QHDJ RU https://pubmed.ncbi.nlm.nih.gov/8565901 DM6QHDJ DI DM6QHDJ DM6QHDJ DN Ornidazole DM6QHDJ MI DE5CJFM DM6QHDJ MN Flavin adenine dinucleotide dehydrogenase (fadd) DM6QHDJ MT DME DM6QHDJ MA Metabolism DM6QHDJ RN Reduction of azo dyes and nitroaromatic compounds by bacterial enzymes from the human intestinal tract. Environ Health Perspect. 1995 Jun;103 Suppl 5:17-9. DM6QHDJ RU https://pubmed.ncbi.nlm.nih.gov/8565901 DM6QHDJ DI DM6QHDJ DM6QHDJ DN Ornidazole DM6QHDJ MI DE9WXYE DM6QHDJ MN Flavin adenine dinucleotide dehydrogenase (fadd) DM6QHDJ MT DME DM6QHDJ MA Metabolism DM6QHDJ RN Reduction of azo dyes and nitroaromatic compounds by bacterial enzymes from the human intestinal tract. Environ Health Perspect. 1995 Jun;103 Suppl 5:17-9. DM6QHDJ RU https://pubmed.ncbi.nlm.nih.gov/8565901 DM6QHDJ DI DM6QHDJ DM6QHDJ DN Ornidazole DM6QHDJ MI DEX5D46 DM6QHDJ MN Oxygen-insensitive NADPH nitroreductase A (nfsA) DM6QHDJ MT DME DM6QHDJ MA Metabolism DM6QHDJ RN Identification and characterization of SnrA, an inducible oxygen-insensitive nitroreductase in Salmonella enterica serovar Typhimurium TA1535. Mutat Res. 2002 Oct 31;508(1-2):59-70. DM6QHDJ RU https://pubmed.ncbi.nlm.nih.gov/12379462 DMW542E DI DMW542E DMW542E DN Orphenadrine DMW542E MI TT9IK2Z DMW542E MN N-methyl-D-aspartate receptor (NMDAR) DMW542E MT DTT DMW542E MA Antagonist DMW542E RN Involvement of voltage-gated sodium channels blockade in the analgesic effects of orphenadrine. Pain. 2009 Apr;142(3):225-35. DMW542E RU https://pubmed.ncbi.nlm.nih.gov/19217209 DMFIQ20 DI DMFIQ20 DMFIQ20 DN Orphenadrine citrate DMFIQ20 MI DE4LYSA DMFIQ20 MN Cytochrome P450 3A4 (CYP3A4) DMFIQ20 MT DME DMFIQ20 MA Metabolism DMFIQ20 RN Orphenadrine and methimazole inhibit multiple cytochrome P450 enzymes in human liver microsomes. Drug Metab Dispos. 1997 Mar;25(3):390-3. DMFIQ20 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=9172960 DMGO72P DI DMGO72P DMGO72P DN Oseltamivir DMGO72P MI TT50QJ3 DMGO72P MN Influenza Neuraminidase (Influ NA) DMGO72P MT DTT DMGO72P MA Inhibitor DMGO72P RN Current and future antiviral therapy of severe seasonal and avian influenza. Antiviral Res. 2008 Apr;78(1):91-102. DMGO72P RU https://pubmed.ncbi.nlm.nih.gov/18328578 DMGO72P DI DMGO72P DMGO72P DN Oseltamivir DMGO72P MI DTCSGPB DMGO72P MN Multidrug resistance-associated protein 4 (ABCC4) DMGO72P MT DTP DMGO72P MA Substrate DMGO72P RN Limited brain distribution of [3R,4R,5S]-4-acetamido-5-amino-3-(1-ethylpropoxy)-1-cyclohexene-1-carboxylate phosphate (Ro 64-0802), a pharmacologically active form of oseltamivir, by active efflux across the blood-brain barrier mediated by organic anion transporter 3 (Oat3/Slc22a8) and multidrug resistance-associated protein 4 (Mrp4/Abcc4). Drug Metab Dispos. 2009 Feb;37(2):315-21. DMGO72P RU http://www.ncbi.nlm.nih.gov/pubmed/19029202 DMGO72P DI DMGO72P DMGO72P DN Oseltamivir DMGO72P MI DTQ23VB DMGO72P MN Organic anion transporter 1 (SLC22A6) DMGO72P MT DTP DMGO72P MA Substrate DMGO72P RN FDA Drug Development and Drug Interactions DMGO72P RU https://www.fda.gov/drugs/developmentapprovalprocess/developmentresources/druginteractionslabeling/ucm093664.htm#table3-2 DMGO72P DI DMGO72P DMGO72P DN Oseltamivir DMGO72P MI DTVP67E DMGO72P MN Organic anion transporter 3 (SLC22A8) DMGO72P MT DTP DMGO72P MA Substrate DMGO72P RN FDA Drug Development and Drug Interactions DMGO72P RU https://www.fda.gov/drugs/developmentapprovalprocess/developmentresources/druginteractionslabeling/ucm093664.htm#table3-2 DMGO72P DI DMGO72P DMGO72P DN Oseltamivir DMGO72P MI DT9G7XN DMGO72P MN Peptide transporter 1 (SLC15A1) DMGO72P MT DTP DMGO72P MA Substrate DMGO72P RN Oseltamivir (tamiflu) is a substrate of peptide transporter 1. Drug Metab Dispos. 2009 Aug;37(8):1676-81. DMGO72P RU http://www.ncbi.nlm.nih.gov/pubmed/19439487 DMGO72P DI DMGO72P DMGO72P DN Oseltamivir DMGO72P MI DTUGYRD DMGO72P MN P-glycoprotein 1 (ABCB1) DMGO72P MT DTP DMGO72P MA Substrate DMGO72P RN Nonclinical pharmacokinetics of oseltamivir and oseltamivir carboxylate in the central nervous system. Antimicrob Agents Chemother. 2009 Nov;53(11):4753-61. DMGO72P RU http://www.ncbi.nlm.nih.gov/pubmed/19721074 DMIJC9X DI DMIJC9X DMIJC9X DN Osilodrostat DMIJC9X MI TTIQUX7 DMIJC9X MN Steroid 11-beta-hydroxylase (CYP11B1) DMIJC9X MT DTT DMIJC9X MA Modulator DMIJC9X RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health Human Services. 2020 DMIJC9X RU https://www.accessdata.fda.gov/drugsatfda_docs/label/2020/212801s000lbl.pdf DMRJLAT DI DMRJLAT DMRJLAT DN Osimertinib DMRJLAT MI TTGKNB4 DMRJLAT MN Epidermal growth factor receptor (EGFR) DMRJLAT MT DTT DMRJLAT MA Inhibitor DMRJLAT RN AZD9291, an irreversible EGFR TKI, overcomes T790M-mediated resistance to EGFR inhibitors in lung cancer. Cancer Discov. 2014 Sep;4(9):1046-61. DMRJLAT RU https://pubmed.ncbi.nlm.nih.gov/24893891 DMF5ZB3 DI DMF5ZB3 DMF5ZB3 DN OspA lipoprotein DMF5ZB3 MI TTM6QSK DMF5ZB3 MN B-cell receptor CD22 (CD22) DMF5ZB3 MT DTT DMF5ZB3 MA Binder DMF5ZB3 RN Safety and immunogenicity of recombinant Bacille Calmette-Gu |rin (rBCG) expressing Borrelia burgdorferi outer surface protein A (OspA) lipoprotein in adult volunteers: a candidate Lyme disease vaccine. Vaccine. 1999 Feb 26;17(7-8):904-14. DMF5ZB3 RU https://pubmed.ncbi.nlm.nih.gov/10067697 DMC4GEI DI DMC4GEI DMC4GEI DN Ospemifene DMC4GEI MI DEPKLMQ DMC4GEI MN Cytochrome P450 2B6 (CYP2B6) DMC4GEI MT DME DMC4GEI MA Metabolism DMC4GEI RN Ospemifene metabolism in humans in vitro and in vivo: metabolite identification, quantitation, and CYP assignment of major hydroxylations. Drug Metabol Drug Interact. 2013;28(3):153-61. DMC4GEI RU https://www.ncbi.nlm.nih.gov/pubmed/?term=23729558 DMC4GEI DI DMC4GEI DMC4GEI DN Ospemifene DMC4GEI MI DE5IED8 DMC4GEI MN Cytochrome P450 2C9 (CYP2C9) DMC4GEI MT DME DMC4GEI MA Metabolism DMC4GEI RN Ospemifene metabolism in humans in vitro and in vivo: metabolite identification, quantitation, and CYP assignment of major hydroxylations. Drug Metabol Drug Interact. 2013;28(3):153-61. DMC4GEI RU https://www.ncbi.nlm.nih.gov/pubmed/?term=23729558 DMC4GEI DI DMC4GEI DMC4GEI DN Ospemifene DMC4GEI MI DE4LYSA DMC4GEI MN Cytochrome P450 3A4 (CYP3A4) DMC4GEI MT DME DMC4GEI MA Metabolism DMC4GEI RN Ospemifene metabolism in humans in vitro and in vivo: metabolite identification, quantitation, and CYP assignment of major hydroxylations. Drug Metabol Drug Interact. 2013;28(3):153-61. DMC4GEI RU https://www.ncbi.nlm.nih.gov/pubmed/?term=23729558 DMC4GEI DI DMC4GEI DMC4GEI DN Ospemifene DMC4GEI MI TTZAYWL DMC4GEI MN Estrogen receptor (ESR) DMC4GEI MT DTT DMC4GEI MA Modulator DMC4GEI RN Clinical pipeline report, company report or official report of Shionogi (2011). DMC4GEI RU http://www.shionogi.co.jp/index_e.html DMC4GEI DI DMC4GEI DMC4GEI DN Ospemifene DMC4GEI MI DEGTFWK DMC4GEI MN Mephenytoin 4-hydroxylase (CYP2C19) DMC4GEI MT DME DMC4GEI MA Metabolism DMC4GEI RN Ospemifene metabolism in humans in vitro and in vivo: metabolite identification, quantitation, and CYP assignment of major hydroxylations. Drug Metabol Drug Interact. 2013;28(3):153-61. DMC4GEI RU https://www.ncbi.nlm.nih.gov/pubmed/?term=23729558 DM05968 DI DM05968 DM05968 DN Otilonium bromide DM05968 MI TTXHYV6 DM05968 MN Voltage-gated L-type calcium channel (L-CaC) DM05968 MT DTT DM05968 MA Blocker DM05968 RN Emerging drugs for irritable bowel syndrome. Expert Opin Emerg Drugs. 2006 May;11(2):293-313. DM05968 RU https://pubmed.ncbi.nlm.nih.gov/16634703 DMQNI7O DI DMQNI7O DMQNI7O DN OTL-200 DMQNI7O MI TTYQANR DMQNI7O MN Cerebroside-sulfatase (ARSA) DMQNI7O MT DTT DMQNI7O MA Replacement DMQNI7O RN Clinical pipeline report, company report or official report of Orchard Therapeutics. DMQNI7O RU https://www.orchard-tx.com/approach/pipeline/ DME0F98 DI DME0F98 DME0F98 DN Ovine corticotropin-releasing hormone DME0F98 MI TTVIREA DME0F98 MN Adrenergic receptor (ADR) DME0F98 MT DTT DME0F98 MA Modulator DME0F98 RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015 DME0F98 RU https://www.accessdata.fda.gov/scripts/cder/drugsatfda/ DMTAFY4 DI DMTAFY4 DMTAFY4 DN Oxacillin DMTAFY4 MI TTJP4SM DMTAFY4 MN Bacterial Penicillin binding protein (Bact PBP) DMTAFY4 MT DTT DMTAFY4 MA Binder DMTAFY4 RN Novel anion liposome-encapsulated antisense oligonucleotide restores susceptibility of methicillin-resistant Staphylococcus aureus and rescues mice... Antimicrob Agents Chemother. 2009 Jul;53(7):2871-8. DMTAFY4 RU https://pubmed.ncbi.nlm.nih.gov/19433567 DMTAFY4 DI DMTAFY4 DMTAFY4 DN Oxacillin DMTAFY4 MI DE2ARDZ DMTAFY4 MN PenA beta-lactamase (penA1) DMTAFY4 MT DME DMTAFY4 MA Metabolism DMTAFY4 RN Characterization of the penA and penR genes of Burkholderia cepacia 249 which encode the chromosomal class A penicillinase and its LysR-type transcriptional regulator. Antimicrob Agents Chemother. 1997 Nov;41(11):2399-405. DMTAFY4 RU https://pubmed.ncbi.nlm.nih.gov/9371340 DMQNWRD DI DMQNWRD DMQNWRD DN Oxaliplatin DMQNWRD MI DTI7UX6 DMQNWRD MN Breast cancer resistance protein (ABCG2) DMQNWRD MT DTP DMQNWRD MA Substrate DMQNWRD RN Effect of ABCG2 on cytotoxicity of platinum drugs: interference of EGFP. Toxicol In Vitro. 2008 Dec;22(8):1846-52. DMQNWRD RU https://doi.org/10.1016/j.tiv.2008.09.001 DMQNWRD DI DMQNWRD DMQNWRD DN Oxaliplatin DMQNWRD MI DE6OQ3W DMQNWRD MN Cytochrome P450 1A1 (CYP1A1) DMQNWRD MT DME DMQNWRD MA Metabolism DMQNWRD RN The influence of metabolic gene polymorphisms on urinary 1-hydroxypyrene concentrations in Chinese coke oven workers. Sci Total Environ. 2007 Aug 1;381(1-3):38-46. DMQNWRD RU https://www.ncbi.nlm.nih.gov/pubmed/?term=17498780 DMQNWRD DI DMQNWRD DMQNWRD DN Oxaliplatin DMQNWRD MI DEJGDUW DMQNWRD MN Cytochrome P450 1A2 (CYP1A2) DMQNWRD MT DME DMQNWRD MA Metabolism DMQNWRD RN The influence of metabolic gene polymorphisms on urinary 1-hydroxypyrene concentrations in Chinese coke oven workers. Sci Total Environ. 2007 Aug 1;381(1-3):38-46. DMQNWRD RU https://www.ncbi.nlm.nih.gov/pubmed/?term=17498780 DMQNWRD DI DMQNWRD DMQNWRD DN Oxaliplatin DMQNWRD MI DE9QHP6 DMQNWRD MN Cytochrome P450 1B1 (CYP1B1) DMQNWRD MT DME DMQNWRD MA Metabolism DMQNWRD RN The influence of metabolic gene polymorphisms on urinary 1-hydroxypyrene concentrations in Chinese coke oven workers. Sci Total Environ. 2007 Aug 1;381(1-3):38-46. DMQNWRD RU https://www.ncbi.nlm.nih.gov/pubmed/?term=17498780 DMQNWRD DI DMQNWRD DMQNWRD DN Oxaliplatin DMQNWRD MI DEVDYN7 DMQNWRD MN Cytochrome P450 2E1 (CYP2E1) DMQNWRD MT DME DMQNWRD MA Metabolism DMQNWRD RN The influence of metabolic gene polymorphisms on urinary 1-hydroxypyrene concentrations in Chinese coke oven workers. Sci Total Environ. 2007 Aug 1;381(1-3):38-46. DMQNWRD RU https://www.ncbi.nlm.nih.gov/pubmed/?term=17498780 DMQNWRD DI DMQNWRD DMQNWRD DN Oxaliplatin DMQNWRD MI DEYZEJA DMQNWRD MN Glutathione S-transferase mu-1 (GSTM1) DMQNWRD MT DME DMQNWRD MA Metabolism DMQNWRD RN PharmGKB: A worldwide resource for pharmacogenomic information. Wiley Interdiscip Rev Syst Biol Med. 2018 Jul;10(4):e1417. (ID: PA150642262) DMQNWRD RU https://www.pharmgkb.org/pathway/PA150642262 DMQNWRD DI DMQNWRD DMQNWRD DN Oxaliplatin DMQNWRD MI DEK6079 DMQNWRD MN Glutathione S-transferase pi (GSTP1) DMQNWRD MT DME DMQNWRD MA Metabolism DMQNWRD RN PharmGKB: A worldwide resource for pharmacogenomic information. Wiley Interdiscip Rev Syst Biol Med. 2018 Jul;10(4):e1417. (ID: PA150642262) DMQNWRD RU https://www.pharmgkb.org/pathway/PA150642262 DMQNWRD DI DMQNWRD DMQNWRD DN Oxaliplatin DMQNWRD MI DE3PKUG DMQNWRD MN Glutathione S-transferase theta-1 (GSTT1) DMQNWRD MT DME DMQNWRD MA Metabolism DMQNWRD RN PharmGKB: A worldwide resource for pharmacogenomic information. Wiley Interdiscip Rev Syst Biol Med. 2018 Jul;10(4):e1417. (ID: PA150642262) DMQNWRD RU https://www.pharmgkb.org/pathway/PA150642262 DMQNWRD DI DMQNWRD DMQNWRD DN Oxaliplatin DMQNWRD MI DTP8L4F DMQNWRD MN High affinity copper uptake protein 1 (SLC31A1) DMQNWRD MT DTP DMQNWRD MA Substrate DMQNWRD RN Copper transporters regulate the cellular pharmacology and sensitivity to Pt drugs. Crit Rev Oncol Hematol. 2005 Jan;53(1):13-23. DMQNWRD RU http://www.ncbi.nlm.nih.gov/pubmed/15607932 DMQNWRD DI DMQNWRD DMQNWRD DN Oxaliplatin DMQNWRD MI TTUTN1I DMQNWRD MN Human Deoxyribonucleic acid (hDNA) DMQNWRD MT DTT DMQNWRD MA Modulator DMQNWRD RN Structures of oxaliplatin-oligonucleotide adducts from DNA.J Mass Spectrom.2012 Oct;47(10):1282-93. DMQNWRD RU https://www.ncbi.nlm.nih.gov/pubmed/23019159 DMQNWRD DI DMQNWRD DMQNWRD DN Oxaliplatin DMQNWRD MI DE5ME8A DMQNWRD MN Metallothionein-1A (MT1A) DMQNWRD MT DME DMQNWRD MA Metabolism DMQNWRD RN PharmGKB: A worldwide resource for pharmacogenomic information. Wiley Interdiscip Rev Syst Biol Med. 2018 Jul;10(4):e1417. (ID: PA150642262) DMQNWRD RU https://www.pharmgkb.org/pathway/PA150642262 DMQNWRD DI DMQNWRD DMQNWRD DN Oxaliplatin DMQNWRD MI DEFKGT7 DMQNWRD MN Metallothionein-2A (MT2A) DMQNWRD MT DME DMQNWRD MA Metabolism DMQNWRD RN PharmGKB: A worldwide resource for pharmacogenomic information. Wiley Interdiscip Rev Syst Biol Med. 2018 Jul;10(4):e1417. (ID: PA150642262) DMQNWRD RU https://www.pharmgkb.org/pathway/PA150642262 DMQNWRD DI DMQNWRD DMQNWRD DN Oxaliplatin DMQNWRD MI DTFI42L DMQNWRD MN Multidrug resistance-associated protein 2 (ABCC2) DMQNWRD MT DTP DMQNWRD MA Substrate DMQNWRD RN Multidrug Resistance-Associated Protein 2 (MRP2) Mediated Transport of Oxaliplatin-Derived Platinum in Membrane Vesicles. PLoS One. 2015 Jul 1;10(7):e0130727. DMQNWRD RU http://www.ncbi.nlm.nih.gov/pubmed/26131551 DMQNWRD DI DMQNWRD DMQNWRD DN Oxaliplatin DMQNWRD MI DEA3U9Y DMQNWRD MN Myeloperoxidase (MPO) DMQNWRD MT DME DMQNWRD MA Metabolism DMQNWRD RN PharmGKB: A worldwide resource for pharmacogenomic information. Wiley Interdiscip Rev Syst Biol Med. 2018 Jul;10(4):e1417. (ID: PA150642262) DMQNWRD RU https://www.pharmgkb.org/pathway/PA150642262 DMQNWRD DI DMQNWRD DMQNWRD DN Oxaliplatin DMQNWRD MI DTT79CX DMQNWRD MN Organic cation transporter 1 (SLC22A1) DMQNWRD MT DTP DMQNWRD MA Substrate DMQNWRD RN Organic cation transporters are determinants of oxaliplatin cytotoxicity. Cancer Res. 2006 Sep 1;66(17):8847-57. DMQNWRD RU http://www.ncbi.nlm.nih.gov/pubmed/16951202 DMQNWRD DI DMQNWRD DMQNWRD DN Oxaliplatin DMQNWRD MI DT9IDPW DMQNWRD MN Organic cation transporter 2 (SLC22A2) DMQNWRD MT DTP DMQNWRD MA Substrate DMQNWRD RN Relevance of copper transporter 1 and organic cation transporters 1-3 for oxaliplatin uptake and drug resistance in colorectal cancer cells. Metallomics. 2018 Mar 1;10(3):414-425. DMQNWRD RU http://www.ncbi.nlm.nih.gov/pubmed/29417972 DMQNWRD DI DMQNWRD DMQNWRD DN Oxaliplatin DMQNWRD MI DENP5RY DMQNWRD MN Quinone reductase 1 (NQO1) DMQNWRD MT DME DMQNWRD MA Metabolism DMQNWRD RN PharmGKB: A worldwide resource for pharmacogenomic information. Wiley Interdiscip Rev Syst Biol Med. 2018 Jul;10(4):e1417. (ID: PA150642262) DMQNWRD RU https://www.pharmgkb.org/pathway/PA150642262 DMQNWRD DI DMQNWRD DMQNWRD DN Oxaliplatin DMQNWRD MI DEUTDON DMQNWRD MN Superoxide dismutase 1 (SOD1) DMQNWRD MT DME DMQNWRD MA Metabolism DMQNWRD RN PharmGKB: A worldwide resource for pharmacogenomic information. Wiley Interdiscip Rev Syst Biol Med. 2018 Jul;10(4):e1417. (ID: PA150642262) DMQNWRD RU https://www.pharmgkb.org/pathway/PA150642262 DM2QDX1 DI DM2QDX1 DM2QDX1 DN Oxamniquine DM2QDX1 MI DECB0K3 DM2QDX1 MN Cytochrome P450 2D6 (CYP2D6) DM2QDX1 MT DME DM2QDX1 MA Metabolism DM2QDX1 RN Inhibitory effects of antiparasitic drugs on cytochrome P450 2D6. Eur J Clin Pharmacol. 1995;48(1):35-8. DM2QDX1 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=7621845 DM2QDX1 DI DM2QDX1 DM2QDX1 DN Oxamniquine DM2QDX1 MI TTB1TZG DM2QDX1 MN Schistosoma Deoxyribonucleic acid (Schist DNA) DM2QDX1 MT DTT DM2QDX1 MA Modulator DM2QDX1 RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. DM2QDX1 RU https://www.fda.gov/ DMU9MYJ DI DMU9MYJ DMU9MYJ DN Oxandrolone DMU9MYJ MI TTS64P2 DMU9MYJ MN Androgen receptor (AR) DMU9MYJ MT DTT DMU9MYJ MA Agonist DMU9MYJ RN The effect of oxandrolone treatment on human osteoblastic cells. J Burns Wounds. 2007 Mar 7;6:e4. DMU9MYJ RU https://pubmed.ncbi.nlm.nih.gov/17364004 DMZ30JT DI DMZ30JT DMZ30JT DN Oxantel pamoate DMZ30JT MI TTHDSE2 DMZ30JT MN Bacterial Fumarate reductase flavoprotein (Bact frdA) DMZ30JT MT DTT DMZ30JT MA Inhibitor DMZ30JT RN Fumarate reductase is essential for Helicobacter pylori colonization of the mouse stomach. Microb Pathog. 2000 Nov;29(5):279-87. DMZ30JT RU https://pubmed.ncbi.nlm.nih.gov/11031122 DM9UB0P DI DM9UB0P DM9UB0P DN Oxaprozin DM9UB0P MI DE5IED8 DM9UB0P MN Cytochrome P450 2C9 (CYP2C9) DM9UB0P MT DME DM9UB0P MA Metabolism DM9UB0P RN Oxaprozin and piroxicam, nonsteroidal antiinflammatory drugs with long half-lives: effect of protein-binding differences on steady-state pharmacokinetics. J Clin Pharmacol. 1997 Apr;37(4):267-78. DM9UB0P RU https://www.ncbi.nlm.nih.gov/pubmed/?term=9115051 DM9UB0P DI DM9UB0P DM9UB0P DN Oxaprozin DM9UB0P MI TTK0943 DM9UB0P MN Prostaglandin G/H synthase (COX) DM9UB0P MT DTT DM9UB0P MA Inhibitor DM9UB0P RN The aryl propionic acid R-flurbiprofen selectively induces p75NTR-dependent decreased survival of prostate tumor cells. Cancer Res. 2007 Apr 1;67(7):3254-62. DM9UB0P RU https://pubmed.ncbi.nlm.nih.gov/17409433 DM1F42Z DI DM1F42Z DM1F42Z DN Oxatomide DM1F42Z MI DECB0K3 DM1F42Z MN Cytochrome P450 2D6 (CYP2D6) DM1F42Z MT DME DM1F42Z MA Metabolism DM1F42Z RN Identification of human P450 isoforms involved in the metabolism of the antiallergic drug, oxatomide, and its kinetic parameters and inhibition constants. Biol Pharm Bull. 2005 Feb;28(2):328-34. DM1F42Z RU https://www.ncbi.nlm.nih.gov/pubmed/?term=15684493 DM1F42Z DI DM1F42Z DM1F42Z DN Oxatomide DM1F42Z MI DE4LYSA DM1F42Z MN Cytochrome P450 3A4 (CYP3A4) DM1F42Z MT DME DM1F42Z MA Metabolism DM1F42Z RN Identification of human P450 isoforms involved in the metabolism of the antiallergic drug, oxatomide, and its kinetic parameters and inhibition constants. Biol Pharm Bull. 2005 Feb;28(2):328-34. DM1F42Z RU https://www.ncbi.nlm.nih.gov/pubmed/?term=15684493 DM1F42Z DI DM1F42Z DM1F42Z DN Oxatomide DM1F42Z MI TTTIBOJ DM1F42Z MN Histamine H1 receptor (H1R) DM1F42Z MT DTT DM1F42Z MA Antagonist DM1F42Z RN Intact cell binding for in vitro prediction of sedative and non-sedative histamine H1-receptor antagonists based on receptor internalization. J Pharmacol Sci. 2008 May;107(1):66-79. DM1F42Z RU https://pubmed.ncbi.nlm.nih.gov/18446005 DMXNZM4 DI DMXNZM4 DMXNZM4 DN Oxazepam DMXNZM4 MI DE4LYSA DMXNZM4 MN Cytochrome P450 3A4 (CYP3A4) DMXNZM4 MT DME DMXNZM4 MA Metabolism DMXNZM4 RN Bioreactor systems in drug metabolism: synthesis of cytochrome P450-generated metabolites. Metab Eng. 2000 Apr;2(2):115-25. DMXNZM4 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=10935727 DMXNZM4 DI DMXNZM4 DMXNZM4 DN Oxazepam DMXNZM4 MI DEO1IE3 DMXNZM4 MN Cytochrome P450 3A43 (CYP3A43) DMXNZM4 MT DME DMXNZM4 MA Metabolism DMXNZM4 RN Cytochrome P450 enzyme activity and protein expression in primary porcine enterocyte and hepatocyte cultures. Xenobiotica. 2000 Jan;30(1):27-46. DMXNZM4 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=10659949 DMXNZM4 DI DMXNZM4 DMXNZM4 DN Oxazepam DMXNZM4 MI DEIBDNY DMXNZM4 MN Cytochrome P450 3A5 (CYP3A5) DMXNZM4 MT DME DMXNZM4 MA Metabolism DMXNZM4 RN Cytochrome P450 enzyme activity and protein expression in primary porcine enterocyte and hepatocyte cultures. Xenobiotica. 2000 Jan;30(1):27-46. DMXNZM4 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=10659949 DMXNZM4 DI DMXNZM4 DMXNZM4 DN Oxazepam DMXNZM4 MI DERD86B DMXNZM4 MN Cytochrome P450 3A7 (CYP3A7) DMXNZM4 MT DME DMXNZM4 MA Metabolism DMXNZM4 RN Cytochrome P450 enzyme activity and protein expression in primary porcine enterocyte and hepatocyte cultures. Xenobiotica. 2000 Jan;30(1):27-46. DMXNZM4 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=10659949 DMXNZM4 DI DMXNZM4 DMXNZM4 DN Oxazepam DMXNZM4 MI TTPTXIN DMXNZM4 MN Translocator protein (TSPO) DMXNZM4 MT DTT DMXNZM4 MA Agonist DMXNZM4 RN Effects of the combination of metyrapone and oxazepam on cocaine and food self-administration in rats. Pharmacol Biochem Behav. 2008 Nov;91(1):181-9. DMXNZM4 RU https://pubmed.ncbi.nlm.nih.gov/18692521 DMXNZM4 DI DMXNZM4 DMXNZM4 DN Oxazepam DMXNZM4 MI DEYGVN4 DMXNZM4 MN UDP-glucuronosyltransferase 1A1 (UGT1A1) DMXNZM4 MT DME DMXNZM4 MA Metabolism DMXNZM4 RN Evidence for oxazepam as an in vivo probe of UGT2B15: oxazepam clearance is reduced by UGT2B15 D85Y polymorphism but unaffected by UGT2B17 deletion. Br J Clin Pharmacol. 2009 Nov;68(5):721-30. DMXNZM4 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=19916996 DMXNZM4 DI DMXNZM4 DMXNZM4 DN Oxazepam DMXNZM4 MI DEB3CV1 DMXNZM4 MN UDP-glucuronosyltransferase 2B7 (UGT2B7) DMXNZM4 MT DME DMXNZM4 MA Metabolism DMXNZM4 RN Stereoselective conjugation of oxazepam by human UDP-glucuronosyltransferases (UGTs): S-oxazepam is glucuronidated by UGT2B15, while R-oxazepam is glucuronidated by UGT2B7 and UGT1A9. Drug Metab Dispos. 2002 Nov;30(11):1257-65. DMXNZM4 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=12386133 DM5PU6O DI DM5PU6O DM5PU6O DN Oxcarbazepine DM5PU6O MI DTUGYRD DM5PU6O MN P-glycoprotein 1 (ABCB1) DM5PU6O MT DTP DM5PU6O MA Substrate DM5PU6O RN The transport of antiepileptic drugs by P-glycoprotein. Adv Drug Deliv Rev. 2012 Jul;64(10):930-42. DM5PU6O RU https://doi.org/10.1016/j.addr.2011.12.003 DM5PU6O DI DM5PU6O DM5PU6O DN Oxcarbazepine DM5PU6O MI TTN9VTF DM5PU6O MN Voltage-gated sodium channel alpha Nav1.9 (SCN11A) DM5PU6O MT DTT DM5PU6O MA Blocker DM5PU6O RN Debate: Does genetic information in humans help us treat patients PRO--genetic information in humans helps us treat patients. CON--genetic information does not help at all. Epilepsia. 2008 Dec;49 Suppl 9:13-24. DM5PU6O RU https://pubmed.ncbi.nlm.nih.gov/19087113 DME7KRM DI DME7KRM DME7KRM DN Oxiconazole DME7KRM MI TTTSOUD DME7KRM MN Candida Cytochrome P450 51 (Candi ERG11) DME7KRM MT DTT DME7KRM MA Inhibitor DME7KRM RN Antifungal agents: mechanisms of action. Trends Microbiol. 2003 Jun;11(6):272-9. DME7KRM RU https://pubmed.ncbi.nlm.nih.gov/12823944 DME7KRM DI DME7KRM DME7KRM DN Oxiconazole DME7KRM MI DEGTFWK DME7KRM MN Mephenytoin 4-hydroxylase (CYP2C19) DME7KRM MT DME DME7KRM MA Metabolism DME7KRM RN In vitro metabolism of oxymetazoline: evidence for bioactivation to a reactive metabolite. Drug Metab Dispos. 2011 Apr;39(4):693-702. DME7KRM RU https://www.ncbi.nlm.nih.gov/pubmed/?term=21177487 DM9EQC0 DI DM9EQC0 DM9EQC0 DN Oxidized glutathione DM9EQC0 MI TTEP6RV DM9EQC0 MN Glutathione reductase (GR) DM9EQC0 MT DTT DM9EQC0 MA Inhibitor DM9EQC0 RN The purification and properties of glutathione reductase from the cestode Moniezia expansa. Int J Biochem Cell Biol. 1995 Apr;27(4):393-401. DM9EQC0 RU https://pubmed.ncbi.nlm.nih.gov/7788561 DMRKOS1 DI DMRKOS1 DMRKOS1 DN Oxilofrine DMRKOS1 MI TTVIREA DMRKOS1 MN Adrenergic receptor (ADR) DMRKOS1 MT DTT DMRKOS1 MA Modulator DMRKOS1 RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015 DMRKOS1 RU https://www.accessdata.fda.gov/scripts/cder/drugsatfda/ DM9FKSR DI DM9FKSR DM9FKSR DN Oxitropium bromide DM9FKSR MI TTH18TF DM9FKSR MN Muscarinic acetylcholine receptor M5 (CHRM5) DM9FKSR MT DTT DM9FKSR MA Modulator DM9FKSR RN Natural products as sources of new drugs over the last 25 years. J Nat Prod. 2007 Mar;70(3):461-77. DM9FKSR RU https://pubmed.ncbi.nlm.nih.gov/17309302 DM51OQW DI DM51OQW DM51OQW DN Oxprenolol DM51OQW MI TTR6W5O DM51OQW MN Adrenergic receptor beta-1 (ADRB1) DM51OQW MT DTT DM51OQW MA Antagonist DM51OQW RN Prediction and experimental validation of acute toxicity of beta-blockers in Ceriodaphnia dubia. Environ Toxicol Chem. 2005 Oct;24(10):2470-6. DM51OQW RU https://pubmed.ncbi.nlm.nih.gov/16268148 DM51OQW DI DM51OQW DM51OQW DN Oxprenolol DM51OQW MI DECB0K3 DM51OQW MN Cytochrome P450 2D6 (CYP2D6) DM51OQW MT DME DM51OQW MA Metabolism DM51OQW RN Application of substrate depletion assay to evaluation of CYP isoforms responsible for stereoselective metabolism of carvedilol. Drug Metab Pharmacokinet. 2016 Dec;31(6):425-432. DM51OQW RU https://www.ncbi.nlm.nih.gov/pubmed/?term=27836712 DMLHSE3 DI DMLHSE3 DMLHSE3 DN Oxtriphylline DMLHSE3 MI DEJGDUW DMLHSE3 MN Cytochrome P450 1A2 (CYP1A2) DMLHSE3 MT DME DMLHSE3 MA Metabolism DMLHSE3 RN PharmGKB summary: very important pharmacogene information for CYP1A2. Pharmacogenet Genomics. 2012 Jan;22(1):73-7. DMLHSE3 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=21989077 DMLHSE3 DI DMLHSE3 DMLHSE3 DN Oxtriphylline DMLHSE3 MI TTZCG4L DMLHSE3 MN Phosphodiesterase 3 (PDE3) DMLHSE3 MT DTT DMLHSE3 MA Modulator DMLHSE3 RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. DMLHSE3 RU https://www.fda.gov/ DMLHSE3 DI DMLHSE3 DMLHSE3 DN Oxtriphylline DMLHSE3 MI TTV5CGO DMLHSE3 MN Phosphodiesterase 4 (PDE4) DMLHSE3 MT DTT DMLHSE3 MA Modulator DMLHSE3 RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. DMLHSE3 RU https://www.fda.gov/ DMI0GDH DI DMI0GDH DMI0GDH DN Oxybuprocaine DMI0GDH MI TTRK8B9 DMI0GDH MN Sodium channel unspecific (NaC) DMI0GDH MT DTT DMI0GDH MA Blocker DMI0GDH RN Intrathecal oxybuprocaine and proxymetacaine produced potent and long-lasting spinal anesthesia in rats. Neurosci Lett. 2009 May 1;454(3):249-53. DMI0GDH RU https://pubmed.ncbi.nlm.nih.gov/19429093 DMF2KLU DI DMF2KLU DMF2KLU DN Oxybutynin hydrochloride DMF2KLU MI DE4LYSA DMF2KLU MN Cytochrome P450 3A4 (CYP3A4) DMF2KLU MT DME DMF2KLU MA Metabolism DMF2KLU RN A comparative review of oxybutynin chloride formulations: pharmacokinetics and therapeutic efficacy in overactive bladder. Rev Urol. 2010 Winter;12(1):12-9. DMF2KLU RU https://www.ncbi.nlm.nih.gov/pubmed/?term=20428289 DMF2KLU DI DMF2KLU DMF2KLU DN Oxybutynin hydrochloride DMF2KLU MI DEIBDNY DMF2KLU MN Cytochrome P450 3A5 (CYP3A5) DMF2KLU MT DME DMF2KLU MA Metabolism DMF2KLU RN Stereoselective pharmacokinetics of oxybutynin and N-desethyloxybutynin in vitro and in vivo. Xenobiotica. 2007 Jan;37(1):59-73. DMF2KLU RU https://www.ncbi.nlm.nih.gov/pubmed/?term=17178634 DMF2KLU DI DMF2KLU DMF2KLU DN Oxybutynin hydrochloride DMF2KLU MI TTOXS3C DMF2KLU MN Muscarinic acetylcholine receptor (CHRM) DMF2KLU MT DTT DMF2KLU MA Modulator DMF2KLU RN Effects of propiverine hydrochloride (propiverine) on the muscarinic receptor binding affinity in guinea pig tissues and on salivation in conscious dogs. Nihon Yakurigaku Zasshi. 1999 Mar;113(3):157-66. DMF2KLU RU https://pubmed.ncbi.nlm.nih.gov/10347840 DMXLKHV DI DMXLKHV DMXLKHV DN Oxycodone DMXLKHV MI TT27RFC DMXLKHV MN Opioid receptor delta (OPRD1) DMXLKHV MT DTT DMXLKHV MA Agonist DMXLKHV RN Oxycodone: a pharmacological and clinical review. Clin Transl Oncol. 2007 May;9(5):298-307. DMXLKHV RU https://pubmed.ncbi.nlm.nih.gov/17525040 DMXLKHV DI DMXLKHV DMXLKHV DN Oxycodone DMXLKHV MI TTKWM86 DMXLKHV MN Opioid receptor mu (MOP) DMXLKHV MT DTT DMXLKHV MA Modulator DMXLKHV RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 319). DMXLKHV RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=319 DM8ZXT6 DI DM8ZXT6 DM8ZXT6 DN Oxymetazoline DM8ZXT6 MI TTQ8AFT DM8ZXT6 MN Adrenergic receptor Alpha-2 (ADRA2) DM8ZXT6 MT DTT DM8ZXT6 MA Agonist DM8ZXT6 RN Potent alpha(2A)-adrenoceptor-mediated vasoconstriction by brimonidine in porcine ciliary arteries. Invest Ophthalmol Vis Sci. 2001 Aug;42(9):2049-55. DM8ZXT6 RU https://pubmed.ncbi.nlm.nih.gov/11481271 DM8ZXT6 DI DM8ZXT6 DM8ZXT6 DN Oxymetazoline DM8ZXT6 MI DEYGVN4 DM8ZXT6 MN UDP-glucuronosyltransferase 1A1 (UGT1A1) DM8ZXT6 MT DME DM8ZXT6 MA Metabolism DM8ZXT6 RN Identification and characterization of oxymetazoline glucuronidation in human liver microsomes: evidence for the involvement of UGT1A9. J Pharm Sci. 2011 Feb;100(2):784-93. DM8ZXT6 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=20669329 DMFXUT8 DI DMFXUT8 DMFXUT8 DN Oxymetholone DMFXUT8 MI DEOG15F DMFXUT8 MN Steroid 5-alpha-reductase 1 (SRD5A1) DMFXUT8 MT DME DMFXUT8 MA Metabolism DMFXUT8 RN Androgen physiology. Semin Reprod Med. 2006 Apr;24(2):71-7. DMFXUT8 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=16633980 DM65AGJ DI DM65AGJ DM65AGJ DN Oxymorphone DM65AGJ MI DECB0K3 DM65AGJ MN Cytochrome P450 2D6 (CYP2D6) DM65AGJ MT DME DM65AGJ MA Metabolism DM65AGJ RN Exposure to oral oxycodone is increased by concomitant inhibition of CYP2D6 and 3A4 pathways, but not by inhibition of CYP2D6 alone. Br J Clin Pharmacol. 2010 Jul;70(1):78-87. DM65AGJ RU https://www.ncbi.nlm.nih.gov/pubmed/?term=20642550 DM65AGJ DI DM65AGJ DM65AGJ DN Oxymorphone DM65AGJ MI DE4LYSA DM65AGJ MN Cytochrome P450 3A4 (CYP3A4) DM65AGJ MT DME DM65AGJ MA Metabolism DM65AGJ RN Exposure to oral oxycodone is increased by concomitant inhibition of CYP2D6 and 3A4 pathways, but not by inhibition of CYP2D6 alone. Br J Clin Pharmacol. 2010 Jul;70(1):78-87. DM65AGJ RU https://www.ncbi.nlm.nih.gov/pubmed/?term=20642550 DM65AGJ DI DM65AGJ DM65AGJ DN Oxymorphone DM65AGJ MI TTN4QDT DM65AGJ MN Opioid receptor (OPR) DM65AGJ MT DTT DM65AGJ MA Modulator DM65AGJ RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7094). DM65AGJ RU http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=7094 DMPZS7U DI DMPZS7U DMPZS7U DN Oxyphenbutazone DMPZS7U MI TTFNGC9 DMPZS7U MN Serum albumin (ALB) DMPZS7U MT DTT DMPZS7U MA Modulator DMPZS7U RN Effect of albumin conformation on binding of phenylbutazone and oxyphenbutazone to human serum albumin. J Pharm Sci. 1982 Feb;71(2):241-4. DMPZS7U RU https://www.ncbi.nlm.nih.gov/pubmed/7062254 DM3TABW DI DM3TABW DM3TABW DN Oxyphencyclimine DM3TABW MI TTH18TF DM3TABW MN Muscarinic acetylcholine receptor M5 (CHRM5) DM3TABW MT DTT DM3TABW MA Binder DM3TABW RN Stereoselective interaction of procyclidine, hexahydro-difenidol, hexbutinol and oxyphencyclimine, and of related antagonists, with four muscarinic receptors. Eur J Pharmacol. 1992 Sep 1;227(1):33-42. DM3TABW RU https://pubmed.ncbi.nlm.nih.gov/1426023 DMMQHOZ DI DMMQHOZ DMMQHOZ DN Oxyphenonium DMMQHOZ MI TTZ9SOR DMMQHOZ MN Muscarinic acetylcholine receptor M1 (CHRM1) DMMQHOZ MT DTT DMMQHOZ MA Antagonist DMMQHOZ RN Ultraviolet spectroscopic estimation of microenvironments and bitter tastes of oxyphenonium bromide in cyclodextrin solutions. J Pharm Sci. 1999 Aug;88(8):759-62. DMMQHOZ RU https://pubmed.ncbi.nlm.nih.gov/10430538 DMMQHOZ DI DMMQHOZ DMMQHOZ DN Oxyphenonium DMMQHOZ MI DTT79CX DMMQHOZ MN Organic cation transporter 1 (SLC22A1) DMMQHOZ MT DTP DMMQHOZ MA Substrate DMMQHOZ RN Identification of novel substrates and structure-activity relationship of cellular uptake mediated by human organic cation transporters 1 and 2. J Med Chem. 2013 Sep 26;56(18):7232-42. DMMQHOZ RU http://www.ncbi.nlm.nih.gov/pubmed/23984907 DMOVH1M DI DMOVH1M DMOVH1M DN Oxytetracycline DMOVH1M MI TTQ8KVI DMOVH1M MN Staphylococcus 30S ribosomal subunit (Stap-coc pbp2) DMOVH1M MT DTT DMOVH1M MA Binder DMOVH1M RN Detection of tetracycline resistance genes by PCR methods. Methods Mol Biol. 2004;268:3-13. DMOVH1M RU https://pubmed.ncbi.nlm.nih.gov/15156014 DMDL27I DI DMDL27I DMDL27I DN Oxytocin DMDL27I MI TTSCIUP DMDL27I MN Oxytocin receptor (OTR) DMDL27I MT DTT DMDL27I MA Modulator DMDL27I RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 369). DMDL27I RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=369 DMDL27I DI DMDL27I DMDL27I DN Oxytocin DMDL27I MI TT4TFGN DMDL27I MN Vasopressin V1a receptor (V1AR) DMDL27I MT DTT DMDL27I MA Agonist DMDL27I RN Mapping peptide-binding domains of the human V1a vasopressin receptor with a photoactivatable linear peptide antagonist. J Biol Chem. 1997 Oct 17;272(42):26536-44. DMDL27I RU https://pubmed.ncbi.nlm.nih.gov/9334232 DMDL27I DI DMDL27I DMDL27I DN Oxytocin DMDL27I MI TTL9MHW DMDL27I MN Vasopressin V1b receptor (V1BR) DMDL27I MT DTT DMDL27I MA Agonist DMDL27I RN The human V3 pituitary vasopressin receptor: ligand binding profile and density-dependent signaling pathways. Endocrinology. 1997 Oct;138(10):4109-22. DMDL27I RU https://pubmed.ncbi.nlm.nih.gov/9322919 DMDL27I DI DMDL27I DMDL27I DN Oxytocin DMDL27I MI TTK8R02 DMDL27I MN Vasopressin V2 receptor (V2R) DMDL27I MT DTT DMDL27I MA Agonist DMDL27I RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 368). DMDL27I RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=368 DM1YB0R DI DM1YB0R DM1YB0R DN OZ277 DM1YB0R MI TTZVSJ2 DM1YB0R MN Sarcoplasmic/endoplasmic reticulum calcium ATPase (ATP2A) DM1YB0R MT DTT DM1YB0R MA Inhibitor DM1YB0R RN The fight against drug-resistant malaria: novel plasmodial targets and antimalarial drugs. Curr Med Chem. 2008;15(2):161-71. DM1YB0R RU https://pubmed.ncbi.nlm.nih.gov/18220771 DMT6AM2 DI DMT6AM2 DMT6AM2 DN Ozanimod DMT6AM2 MI TT9JZCK DMT6AM2 MN Sphingosine-1-phosphate receptor 1 (S1PR1) DMT6AM2 MT DTT DMT6AM2 MA Agonist DMT6AM2 RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health Human Services. 2020 DMT6AM2 RU https://www.accessdata.fda.gov/drugsatfda_docs/label/2020/209899s000lbl.pdf DM6KZMG DI DM6KZMG DM6KZMG DN Ozenoxacin DM6KZMG MI TTN6J5F DM6KZMG MN Bacterial DNA gyrase (Bact gyrase) DM6KZMG MT DTT DM6KZMG MA Modulator DM6KZMG RN In vitro and in vivo antibacterial activity of T-3912, a novel non-fluorinated topical quinolone. J Antimicrob Chemother. 2002 Mar;49(3):455-65. DM6KZMG RU https://www.ncbi.nlm.nih.gov/pubmed/11864945 DM6KZMG DI DM6KZMG DM6KZMG DN Ozenoxacin DM6KZMG MI TTABD5E DM6KZMG MN DNA replication (DNA repli) DM6KZMG MT DTT DM6KZMG MA Inhibitor DM6KZMG RN 2017 FDA drug approvals.Nat Rev Drug Discov. 2018 Feb;17(2):81-85. DM6KZMG RU https://pubmed.ncbi.nlm.nih.gov/29348678 DM6KZMG DI DM6KZMG DM6KZMG DN Ozenoxacin DM6KZMG MI TTRVWAT DM6KZMG MN Staphylococcus DNA gyrase A (Stap-coc gyrA) DM6KZMG MT DTT DM6KZMG MA Inhibitor DM6KZMG RN 2017 FDA drug approvals.Nat Rev Drug Discov. 2018 Feb;17(2):81-85. DM6KZMG RU https://pubmed.ncbi.nlm.nih.gov/29348678 DM6KZMG DI DM6KZMG DM6KZMG DN Ozenoxacin DM6KZMG MI TTIXTO3 DM6KZMG MN Staphylococcus Topoisomerase IV (Stap-coc parC) DM6KZMG MT DTT DM6KZMG MA Modulator DM6KZMG RN In vitro and in vivo antibacterial activity of T-3912, a novel non-fluorinated topical quinolone. J Antimicrob Chemother. 2002 Mar;49(3):455-65. DM6KZMG RU https://www.ncbi.nlm.nih.gov/pubmed/11864945 DMNKT8Z DI DMNKT8Z DMNKT8Z DN Pachycarpine DMNKT8Z MI TTRK8B9 DMNKT8Z MN Sodium channel unspecific (NaC) DMNKT8Z MT DTT DMNKT8Z MA Modulator DMNKT8Z RN Medicinal plants in therapy. Bull World Health Organ. 1985;63(6):965-81. DMNKT8Z RU https://pubmed.ncbi.nlm.nih.gov/3879679 DMLB81S DI DMLB81S DMLB81S DN Paclitaxel DMLB81S MI DTI7UX6 DMLB81S MN Breast cancer resistance protein (ABCG2) DMLB81S MT DTP DMLB81S MA Substrate DMLB81S RN Ixabepilone, a novel microtubule-targeting agent for breast cancer, is a substrate for P-glycoprotein (P-gp/MDR1/ABCB1) but not breast cancer resistance protein (BCRP/ABCG2). J Pharmacol Exp Ther. 2011 May;337(2):423-32. DMLB81S RU http://www.ncbi.nlm.nih.gov/pubmed/21262849 DMLB81S DI DMLB81S DMLB81S DN Paclitaxel DMLB81S MI DTZRMK5 DMLB81S MN Multidrug resistance protein 3 (ABCB4) DMLB81S MT DTP DMLB81S MA Substrate DMLB81S RN MDR3 P-glycoprotein, a phosphatidylcholine translocase, transports several cytotoxic drugs and directly interacts with drugs as judged by interference with nucleotide trapping. J Biol Chem. 2000 Aug 4;275(31):23530-9. DMLB81S RU http://www.ncbi.nlm.nih.gov/pubmed/10918072 DMLB81S DI DMLB81S DMLB81S DN Paclitaxel DMLB81S MI DTSYQGK DMLB81S MN Multidrug resistance-associated protein 1 (ABCC1) DMLB81S MT DTP DMLB81S MA Substrate DMLB81S RN Human intestinal transporter database: QSAR modeling and virtual profiling of drug uptake, efflux and interactions. Pharm Res. 2013 Apr;30(4):996-1007. DMLB81S RU https://doi.org/10.1007/s11095-012-0935-x DMLB81S DI DMLB81S DMLB81S DN Paclitaxel DMLB81S MI DTFI42L DMLB81S MN Multidrug resistance-associated protein 2 (ABCC2) DMLB81S MT DTP DMLB81S MA Substrate DMLB81S RN Multidrug resistance protein 2 is an important determinant of paclitaxel pharmacokinetics. Clin Cancer Res. 2006 Oct 15;12(20 Pt 1):6125-32. DMLB81S RU http://www.ncbi.nlm.nih.gov/pubmed/17062689 DMLB81S DI DMLB81S DMLB81S DN Paclitaxel DMLB81S MI DTQ3ZHF DMLB81S MN Multidrug resistance-associated protein 3 (ABCC3) DMLB81S MT DTP DMLB81S MA Substrate DMLB81S RN Functional genomics identifies ABCC3 as a mediator of taxane resistance in HER2-amplified breast cancer. Cancer Res. 2008 Jul 1;68(13):5380-9. DMLB81S RU https://doi.org/10.1158/0008-5472.CAN-08-0234 DMLB81S DI DMLB81S DMLB81S DN Paclitaxel DMLB81S MI DTPS120 DMLB81S MN Multidrug resistance-associated protein 7 (ABCC10) DMLB81S MT DTP DMLB81S MA Substrate DMLB81S RN Modulation of the ATPase and transport activities of broad-acting multidrug resistance factor ABCC10 (MRP7). Cancer Res. 2012 Dec 15;72(24):6457-67. DMLB81S RU http://www.ncbi.nlm.nih.gov/pubmed/23087055 DMLB81S DI DMLB81S DMLB81S DN Paclitaxel DMLB81S MI DT0OC1Q DMLB81S MN Organic anion transporter 2 (SLC22A7) DMLB81S MT DTP DMLB81S MA Substrate DMLB81S RN Transport mechanism and substrate specificity of human organic anion transporter 2 (hOat2 [SLC22A7]). J Pharm Pharmacol. 2005 May;57(5):573-8. DMLB81S RU http://www.ncbi.nlm.nih.gov/pubmed/15901346 DMLB81S DI DMLB81S DMLB81S DN Paclitaxel DMLB81S MI DT3D8F0 DMLB81S MN Organic anion transporting polypeptide 1B1 (SLCO1B1) DMLB81S MT DTP DMLB81S MA Substrate DMLB81S RN Interaction of human organic anion transporter polypeptides 1B1 and 1B3 with antineoplastic compounds. Eur J Med Chem. 2015 Mar 6;92:723-31. DMLB81S RU http://www.ncbi.nlm.nih.gov/pubmed/25618019 DMLB81S DI DMLB81S DMLB81S DN Paclitaxel DMLB81S MI DT9C1TS DMLB81S MN Organic anion transporting polypeptide 1B3 (SLCO1B3) DMLB81S MT DTP DMLB81S MA Substrate DMLB81S RN Identification of OATP1B3 as a high-affinity hepatocellular transporter of paclitaxel. Cancer Biol Ther. 2005 Aug;4(8):815-8. DMLB81S RU http://www.ncbi.nlm.nih.gov/pubmed/16210916 DMLB81S DI DMLB81S DMLB81S DN Paclitaxel DMLB81S MI DTUGYRD DMLB81S MN P-glycoprotein 1 (ABCB1) DMLB81S MT DTP DMLB81S MA Substrate DMLB81S RN Kinetics of P-glycoprotein-mediated efflux of paclitaxel. J Pharmacol Exp Ther. 2001 Sep;298(3):1236-42. DMLB81S RU http://www.ncbi.nlm.nih.gov/pubmed/11504826 DMLB81S DI DMLB81S DMLB81S DN Paclitaxel DMLB81S MI DT68UV2 DMLB81S MN TAP-like protein (ABCB9) DMLB81S MT DTP DMLB81S MA Substrate DMLB81S RN Overexpression of microRNA-24 increases the sensitivity to paclitaxel in drug-resistant breast carcinoma cell lines via targeting ABCB9. Oncol Lett. 2016 Nov;12(5):3905-3911. DMLB81S RU http://www.ncbi.nlm.nih.gov/pubmed/27895747 DMD7L94 DI DMD7L94 DMD7L94 DN Palbociclib DMD7L94 MI DTI7UX6 DMD7L94 MN Breast cancer resistance protein (ABCG2) DMD7L94 MT DTP DMD7L94 MA Substrate DMD7L94 RN Efflux transporters at the blood-brain barrier limit delivery and efficacy of cyclin-dependent kinase 4/6 inhibitor palbociclib (PD-0332991) in an orthotopic brain tumor model. J Pharmacol Exp Ther. 2015 Nov;355(2):264-71. DMD7L94 RU http://www.ncbi.nlm.nih.gov/pubmed/26354993 DMD7L94 DI DMD7L94 DMD7L94 DN Palbociclib DMD7L94 MI TT0PG8F DMD7L94 MN Cyclin-dependent kinase 4 (CDK4) DMD7L94 MT DTT DMD7L94 MA Modulator DMD7L94 RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health Human Services. 2017 DMD7L94 RU https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/207103s004lbl.pdf DMD7L94 DI DMD7L94 DMD7L94 DN Palbociclib DMD7L94 MI TTO0FDJ DMD7L94 MN Cyclin-dependent kinase 6 (CDK6) DMD7L94 MT DTT DMD7L94 MA Modulator DMD7L94 RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health Human Services. 2017 DMD7L94 RU https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/207103s004lbl.pdf DMD7L94 DI DMD7L94 DMD7L94 DN Palbociclib DMD7L94 MI DE4LYSA DMD7L94 MN Cytochrome P450 3A4 (CYP3A4) DMD7L94 MT DME DMD7L94 MA Metabolism DMD7L94 RN Progress with palbociclib in breast cancer: latest evidence and clinical considerations. Ther Adv Med Oncol. 2017 Feb;9(2):83-105. DMD7L94 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=28203301 DMD7L94 DI DMD7L94 DMD7L94 DN Palbociclib DMD7L94 MI DTUGYRD DMD7L94 MN P-glycoprotein 1 (ABCB1) DMD7L94 MT DTP DMD7L94 MA Substrate DMD7L94 RN Efflux transporters at the blood-brain barrier limit delivery and efficacy of cyclin-dependent kinase 4/6 inhibitor palbociclib (PD-0332991) in an orthotopic brain tumor model. J Pharmacol Exp Ther. 2015 Nov;355(2):264-71. DMD7L94 RU http://www.ncbi.nlm.nih.gov/pubmed/26354993 DM9JOYP DI DM9JOYP DM9JOYP DN Palifermin DM9JOYP MI TTGJVQM DM9JOYP MN Fibroblast growth factor receptor 2 (FGFR2) DM9JOYP MT DTT DM9JOYP MA Binder DM9JOYP RN Keratinocyte growth factor. Expert Opin Biol Ther. 2009 Jun;9(6):779-87. DM9JOYP RU https://pubmed.ncbi.nlm.nih.gov/19456212 DM7NPJS DI DM7NPJS DM7NPJS DN Paliperidone DM7NPJS MI TT85JO3 DM7NPJS MN 5-HT receptor (5HTR) DM7NPJS MT DTT DM7NPJS MA Antagonist DM7NPJS RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015 DM7NPJS RU https://www.accessdata.fda.gov/scripts/cder/drugsatfda/ DM7NPJS DI DM7NPJS DM7NPJS DN Paliperidone DM7NPJS MI DECB0K3 DM7NPJS MN Cytochrome P450 2D6 (CYP2D6) DM7NPJS MT DME DM7NPJS MA Metabolism DM7NPJS RN Interpreting serum risperidone concentrations. Pharmacotherapy. 2005 Feb;25(2):299-302. DM7NPJS RU https://www.ncbi.nlm.nih.gov/pubmed/?term=15767244 DM7NPJS DI DM7NPJS DM7NPJS DN Paliperidone DM7NPJS MI DE4LYSA DM7NPJS MN Cytochrome P450 3A4 (CYP3A4) DM7NPJS MT DME DM7NPJS MA Metabolism DM7NPJS RN ABCB1 polymorphisms influence steady-state plasma levels of 9-hydroxyrisperidone and risperidone active moiety. Ther Drug Monit. 2008 Oct;30(5):628-33. DM7NPJS RU https://www.ncbi.nlm.nih.gov/pubmed/?term=18708991 DM7NPJS DI DM7NPJS DM7NPJS DN Paliperidone DM7NPJS MI DEIBDNY DM7NPJS MN Cytochrome P450 3A5 (CYP3A5) DM7NPJS MT DME DM7NPJS MA Metabolism DM7NPJS RN Different enantioselective 9-hydroxylation of risperidone by the two human CYP2D6 and CYP3A4 enzymes. Drug Metab Dispos. 2001 Oct;29(10):1263-8. DM7NPJS RU https://www.ncbi.nlm.nih.gov/pubmed/?term=11560868 DM7NPJS DI DM7NPJS DM7NPJS DN Paliperidone DM7NPJS MI DTUGYRD DM7NPJS MN P-glycoprotein 1 (ABCB1) DM7NPJS MT DTP DM7NPJS MA Substrate DM7NPJS RN Invega (paliperidone) extended release tablets FDA Label DM7NPJS RU https://www.accessdata.fda.gov/drugsatfda_docs/label/2010/021999s018lbl.pdf DMQM9S0 DI DMQM9S0 DMQM9S0 DN Palivizumab DMQM9S0 MI TT57ID8 DMQM9S0 MN Respiratory syncytial virus protein F (RSV F) DMQM9S0 MT DTT DMQM9S0 MA Modulator DMQM9S0 RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. DMQM9S0 RU https://www.fda.gov/ DMBHMOX DI DMBHMOX DMBHMOX DN Palonosetron DMBHMOX MI TTPC4TU DMBHMOX MN 5-HT 3A receptor (HTR3A) DMBHMOX MT DTT DMBHMOX MA Antagonist DMBHMOX RN Management of postoperative nausea and vomiting: focus on palonosetron. Ther Clin Risk Manag. 2009 Feb;5(1):21-34. DMBHMOX RU https://pubmed.ncbi.nlm.nih.gov/19436621 DMBHMOX DI DMBHMOX DMBHMOX DN Palonosetron DMBHMOX MI DECB0K3 DMBHMOX MN Cytochrome P450 2D6 (CYP2D6) DMBHMOX MT DME DMBHMOX MA Metabolism DMBHMOX RN Cytochrome P450 2D6 metabolism and 5-hydroxytryptamine type 3 receptor antagonists for postoperative nausea and vomiting. Med Sci Monit. 2005 Oct;11(10):RA322-8. DMBHMOX RU https://www.ncbi.nlm.nih.gov/pubmed/?term=16192915 DMBHMOX DI DMBHMOX DMBHMOX DN Palonosetron DMBHMOX MI DE4LYSA DMBHMOX MN Cytochrome P450 3A4 (CYP3A4) DMBHMOX MT DME DMBHMOX MA Metabolism DMBHMOX RN Pharmacokinetics, metabolism and excretion of intravenous [l4C]-palonosetron in healthy human volunteers. Biopharm Drug Dispos. 2004 Nov;25(8):329-37. DMBHMOX RU https://www.ncbi.nlm.nih.gov/pubmed/?term=15378559 DMK2PBD DI DMK2PBD DMK2PBD DN Palonosetron + fosnetupitant DMK2PBD MI TTPC4TU DMK2PBD MN 5-HT 3A receptor (HTR3A) DMK2PBD MT DTT DMK2PBD MA Antagonist DMK2PBD RN 2018 FDA drug approvals.Nat Rev Drug Discov. 2019 Feb;18(2):85-89. DMK2PBD RU https://pubmed.ncbi.nlm.nih.gov/30710142 DMK2PBD DI DMK2PBD DMK2PBD DN Palonosetron + fosnetupitant DMK2PBD MI TTZPO1L DMK2PBD MN Substance-P receptor (TACR1) DMK2PBD MT DTT DMK2PBD MA Antagonist DMK2PBD RN 2018 FDA drug approvals.Nat Rev Drug Discov. 2019 Feb;18(2):85-89. DMK2PBD RU https://pubmed.ncbi.nlm.nih.gov/30710142 DMB4AVP DI DMB4AVP DMB4AVP DN Pamidronate DMB4AVP MI TTIKWV4 DMB4AVP MN Geranyltranstransferase (FDPS) DMB4AVP MT DTT DMB4AVP MA Inhibitor DMB4AVP RN Detection of nonsterol isoprenoids by HPLC-MS/MS. Anal Biochem. 2008 Dec 1;383(1):18-24. DMB4AVP RU https://pubmed.ncbi.nlm.nih.gov/18782552 DMB0VY8 DI DMB0VY8 DMB0VY8 DN Pancuronium DMB0VY8 MI TTJSZTB DMB0VY8 MN Nicotinic acetylcholine receptor (nAChR) DMB0VY8 MT DTT DMB0VY8 MA Antagonist DMB0VY8 RN Pharmacological characteristics of the inhibition of nondepolarizing neuromuscular blocking agents at human adult muscle nicotinic acetylcholine receptor. Anesthesiology. 2009 Jun;110(6):1244-52. DMB0VY8 RU https://pubmed.ncbi.nlm.nih.gov/19417616 DMQPD1F DI DMQPD1F DMQPD1F DN Panitumumab DMQPD1F MI TTGKNB4 DMQPD1F MN Epidermal growth factor receptor (EGFR) DMQPD1F MT DTT DMQPD1F MA Suppressor DMQPD1F RN Integration of panitumumab into the treatment of colorectal cancer. Crit Rev Oncol Hematol. 2010 Apr;74(1):16-26. DMQPD1F RU https://pubmed.ncbi.nlm.nih.gov/19616446 DM58WKG DI DM58WKG DM58WKG DN Panobinostat DM58WKG MI DE4LYSA DM58WKG MN Cytochrome P450 3A4 (CYP3A4) DM58WKG MT DME DM58WKG MA Metabolism DM58WKG RN Panobinostat for the treatment of relapsed or relapsed/refractory multiple myeloma: pharmacology and clinical outcomes. Expert Rev Clin Pharmacol. 2016;9(1):35-48. DM58WKG RU https://www.ncbi.nlm.nih.gov/pubmed/?term=26503877 DM58WKG DI DM58WKG DM58WKG DN Panobinostat DM58WKG MI TT6R7JZ DM58WKG MN Histone deacetylase 1 (HDAC1) DM58WKG MT DTT DM58WKG MA Inhibitor DM58WKG RN Protein methyltransferases as a target class for drug discovery. Nat Rev Drug Discov. 2009 Sep;8(9):724-32. DM58WKG RU https://pubmed.ncbi.nlm.nih.gov/19721445 DM58WKG DI DM58WKG DM58WKG DN Panobinostat DM58WKG MI DTUGYRD DM58WKG MN P-glycoprotein 1 (ABCB1) DM58WKG MT DTP DM58WKG MA Substrate DM58WKG RN Panobinostat for the treatment of multiple myeloma: the evidence to date. J Blood Med. 2015 Oct 8;6:269-76. 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DMCA9QP RU https://pubmed.ncbi.nlm.nih.gov/12646997 DMOC1BX DI DMOC1BX DMOC1BX DN Paraldehyde DMOC1BX MI DEWYTJB DMOC1BX MN Aldehyde dehydrogenase 2 (ALDH2) DMOC1BX MT DME DMOC1BX MA Metabolism DMOC1BX RN Paraldehyde. J Appl Toxicol. 1991 Oct;11(5):379-81. DMOC1BX RU https://www.ncbi.nlm.nih.gov/pubmed/?term=1783744 DMR5ZUP DI DMR5ZUP DMR5ZUP DN Paramethadione DMR5ZUP MI DE5IED8 DMR5ZUP MN Cytochrome P450 2C9 (CYP2C9) DMR5ZUP MT DME DMR5ZUP MA Metabolism DMR5ZUP RN Involvement of cytochrome P450 2C9, 2E1 and 3A4 in trimethadione N-demethylation in human microsomes. J Clin Pharm Ther. 2003 Dec;28(6):493-6. DMR5ZUP RU https://www.ncbi.nlm.nih.gov/pubmed/?term=14651673 DMR5ZUP DI DMR5ZUP DMR5ZUP DN Paramethadione DMR5ZUP MI DEVDYN7 DMR5ZUP MN Cytochrome P450 2E1 (CYP2E1) DMR5ZUP MT DME DMR5ZUP MA Metabolism DMR5ZUP RN Cytochrome P450 2E1: its clinical and toxicological role. J Clin Pharm Ther. 2000 Jun;25(3):165-75. 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DMR5ZUP RU https://pubmed.ncbi.nlm.nih.gov/17291698 DM6PR40 DI DM6PR40 DM6PR40 DN Paramethasone DM6PR40 MI TTJL8VG DM6PR40 MN Corticosteroid-binding globulin (SERPINA6) DM6PR40 MT DTT DM6PR40 MA Binder DM6PR40 RN Novel human corticosteroid-binding globulin variant with low cortisol-binding affinity. J Clin Endocrinol Metab. 2000 Jan;85(1):361-7. DM6PR40 RU https://pubmed.ncbi.nlm.nih.gov/10634411 DM6PR40 DI DM6PR40 DM6PR40 DN Paramethasone DM6PR40 MI DE4LYSA DM6PR40 MN Cytochrome P450 3A4 (CYP3A4) DM6PR40 MT DME DM6PR40 MA Metabolism DM6PR40 RN Regulation of drug-metabolizing cytochrome P450 enzymes by glucocorticoids. Drug Metab Rev. 2010 Nov;42(4):621-35. DM6PR40 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=20482443 DMM0HR1 DI DMM0HR1 DMM0HR1 DN Pargyline DMM0HR1 MI TT32XQJ DMM0HR1 MN Monoamine oxidase (MAO) DMM0HR1 MT DTT DMM0HR1 MA Inhibitor DMM0HR1 RN Novel monoamine oxidase inhibitors: a patent review (2012 - 2014).Expert Opin Ther Pat. 2015 Jan;25(1):91-110. DMM0HR1 RU https://www.ncbi.nlm.nih.gov/pubmed/25399762 DMM0HR1 DI DMM0HR1 DMM0HR1 DN Pargyline DMM0HR1 MI TTGP7BY DMM0HR1 MN Monoamine oxidase type B (MAO-B) DMM0HR1 MT DTT DMM0HR1 MA Inhibitor DMM0HR1 RN Dose-dependent activation of distinct hypertrophic pathways by serotonin in cardiac cells. Am J Physiol Heart Circ Physiol. 2009 Aug;297(2):H821-8. DMM0HR1 RU https://pubmed.ncbi.nlm.nih.gov/19542488 DMYBV3G DI DMYBV3G DMYBV3G DN Paricalcitol DMYBV3G MI TTK59TV DMYBV3G MN Vitamin D3 receptor (VDR) DMYBV3G MT DTT DMYBV3G MA Agonist DMYBV3G RN New acquisitions in therapy of secondary hyperparathyroidism in chronic kidney disease and peritoneal dialysis patients: role of vitamin D receptor... Contrib Nephrol. 2009;163:219-226. DMYBV3G RU https://pubmed.ncbi.nlm.nih.gov/19494617 DM1AGXN DI DM1AGXN DM1AGXN DN Paromomycin DM1AGXN MI TTQ8KVI DM1AGXN MN Staphylococcus 30S ribosomal subunit (Stap-coc pbp2) DM1AGXN MT DTT DM1AGXN MA Binder DM1AGXN RN Aminoglycoside association pathways with the 30S ribosomal subunit. J Phys Chem B. 2009 May 21;113(20):7322-30. DM1AGXN RU https://pubmed.ncbi.nlm.nih.gov/19438282 DM5PVQE DI DM5PVQE DM5PVQE DN Paroxetine DM5PVQE MI DEJGDUW DM5PVQE MN Cytochrome P450 1A2 (CYP1A2) DM5PVQE MT DME DM5PVQE MA Metabolism DM5PVQE RN CYP1A2 genetic polymorphisms are associated with treatment response to the antidepressant paroxetine. Pharmacogenomics. 2010 Nov;11(11):1535-43. DM5PVQE RU https://www.ncbi.nlm.nih.gov/pubmed/?term=21121774 DM5PVQE DI DM5PVQE DM5PVQE DN Paroxetine DM5PVQE MI DECB0K3 DM5PVQE MN Cytochrome P450 2D6 (CYP2D6) DM5PVQE MT DME DM5PVQE MA Metabolism DM5PVQE RN Clinical pharmacogenetics implementation consortium (CPIC) guideline for CYP2D6 and CYP2C19 genotypes and dosing of selective serotonin reuptake inhibitors. Clin Pharmacol Ther. 2015 Aug;98(2):127-34. DM5PVQE RU https://www.ncbi.nlm.nih.gov/pubmed/?term=25974703 DM5PVQE DI DM5PVQE DM5PVQE DN Paroxetine DM5PVQE MI DE4LYSA DM5PVQE MN Cytochrome P450 3A4 (CYP3A4) DM5PVQE MT DME DM5PVQE MA Metabolism DM5PVQE RN New orally active anticoagulant agents for the prevention and treatment of venous thromboembolism in cancer patients. Ther Clin Risk Manag. 2014 Jun 13;10:423-36. DM5PVQE RU https://www.ncbi.nlm.nih.gov/pubmed/?term=24966680 DM5PVQE DI DM5PVQE DM5PVQE DN Paroxetine DM5PVQE MI DEGTFWK DM5PVQE MN Mephenytoin 4-hydroxylase (CYP2C19) DM5PVQE MT DME DM5PVQE MA Metabolism DM5PVQE RN Identification of cytochrome P450 isoforms involved in the metabolism of paroxetine and estimation of their importance for human paroxetine metabolism using a population-based simulator. Drug Metab Dispos. 2010 Mar;38(3):376-85. DM5PVQE RU https://www.ncbi.nlm.nih.gov/pubmed/?term=20007670 DM5PVQE DI DM5PVQE DM5PVQE DN Paroxetine DM5PVQE MI DTUGYRD DM5PVQE MN P-glycoprotein 1 (ABCB1) DM5PVQE MT DTP DM5PVQE MA Substrate DM5PVQE RN Improving the prediction of the brain disposition for orally administered drugs using BDDCS. Adv Drug Deliv Rev. 2012 Jan;64(1):95-109. DM5PVQE RU https://doi.org/10.1016/j.addr.2011.12.008 DM5PVQE DI DM5PVQE DM5PVQE DN Paroxetine DM5PVQE MI TT3ROYC DM5PVQE MN Serotonin transporter (SERT) DM5PVQE MT DTT DM5PVQE MA Modulator DM5PVQE RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. DM5PVQE RU https://www.fda.gov/ DMHM7JS DI DMHM7JS DMHM7JS DN Pasireotide DMHM7JS MI TTIND6G DMHM7JS MN Somatostatin receptor type 1 (SSTR1) DMHM7JS MT DTT DMHM7JS MA Inhibitor DMHM7JS RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 355). DMHM7JS RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=355 DMHM7JS DI DMHM7JS DMHM7JS DN Pasireotide DMHM7JS MI TTZ6T9E DMHM7JS MN Somatostatin receptor type 2 (SSTR2) DMHM7JS MT DTT DMHM7JS MA Inhibitor DMHM7JS RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 356). DMHM7JS RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=356 DMHM7JS DI DMHM7JS DMHM7JS DN Pasireotide DMHM7JS MI TTJX3UE DMHM7JS MN Somatostatin receptor type 3 (SSTR3) DMHM7JS MT DTT DMHM7JS MA Inhibitor DMHM7JS RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 357). DMHM7JS RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=357 DMHM7JS DI DMHM7JS DMHM7JS DN Pasireotide DMHM7JS MI TT2BC4G DMHM7JS MN Somatostatin receptor type 5 (SSTR5) DMHM7JS MT DTT DMHM7JS MA Inhibitor DMHM7JS RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 359). DMHM7JS RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=359 DMMIQ20 DI DMMIQ20 DMMIQ20 DN Patiromer calcium DMMIQ20 MI TTB0SC6 DMMIQ20 MN Potassium (K) DMMIQ20 MT DTT DMMIQ20 MA Binder DMMIQ20 RN Evaluation of the efficacy and safety of RLY5016, a polymeric potassium binder, in a double-blind, placebo-controlled study in patients with chronic heart failure (the PEARL-HF) trial. Eur Heart J. 2011 Apr;32(7):820-8. DMMIQ20 RU https://pubmed.ncbi.nlm.nih.gov/21208974 DMWSA0V DI DMWSA0V DMWSA0V DN Patisiran DMWSA0V MI TTPOYU7 DMWSA0V MN Transthyretin messenger RNA (TTR mRNA) DMWSA0V MT DTT DMWSA0V RN Clinical pipeline report, company report or official report of Alnylam Pharmaceuticals, Inc. DMWSA0V RU http://www.alnylam.com/product-pipeline/ttr-amyloidosis-fac/ DMF57DM DI DMF57DM DMF57DM DN Pazopanib DMF57DM MI DEJGDUW DMF57DM MN Cytochrome P450 1A2 (CYP1A2) DMF57DM MT DME DMF57DM MA Metabolism DMF57DM RN Pazopanib, a new therapy for metastatic soft tissue sarcoma. Expert Opin Pharmacother. 2013 May;14(7):929-35. DMF57DM RU https://www.ncbi.nlm.nih.gov/pubmed/?term=23488774 DMF57DM DI DMF57DM DMF57DM DN Pazopanib DMF57DM MI DES5XRU DMF57DM MN Cytochrome P450 2C8 (CYP2C8) DMF57DM MT DME DMF57DM MA Metabolism DMF57DM RN Pazopanib, a new therapy for metastatic soft tissue sarcoma. Expert Opin Pharmacother. 2013 May;14(7):929-35. DMF57DM RU https://www.ncbi.nlm.nih.gov/pubmed/?term=23488774 DMF57DM DI DMF57DM DMF57DM DN Pazopanib DMF57DM MI DECB0K3 DMF57DM MN Cytochrome P450 2D6 (CYP2D6) DMF57DM MT DME DMF57DM MA Metabolism DMF57DM RN Pazopanib: the newest tyrosine kinase inhibitor for the treatment of advanced or metastatic renal cell carcinoma. Drugs. 2011 Mar 5;71(4):443-54. DMF57DM RU https://www.ncbi.nlm.nih.gov/pubmed/?term=21395357 DMF57DM DI DMF57DM DMF57DM DN Pazopanib DMF57DM MI DE4LYSA DMF57DM MN Cytochrome P450 3A4 (CYP3A4) DMF57DM MT DME DMF57DM MA Metabolism DMF57DM RN Pazopanib, a new therapy for metastatic soft tissue sarcoma. Expert Opin Pharmacother. 2013 May;14(7):929-35. DMF57DM RU https://www.ncbi.nlm.nih.gov/pubmed/?term=23488774 DM6U9CQ DI DM6U9CQ DM6U9CQ DN Pazopanib HCl DM6U9CQ MI DTI7UX6 DM6U9CQ MN Breast cancer resistance protein (ABCG2) DM6U9CQ MT DTP DM6U9CQ MA Substrate DM6U9CQ RN Bioavailability, metabolism and disposition of oral pazopanib in patients with advanced cancer. Xenobiotica. 2013 May;43(5):443-53. DM6U9CQ RU http://www.ncbi.nlm.nih.gov/pubmed/23548165 DM6U9CQ DI DM6U9CQ DM6U9CQ DN Pazopanib HCl DM6U9CQ MI DT3D8F0 DM6U9CQ MN Organic anion transporting polypeptide 1B1 (SLCO1B1) DM6U9CQ MT DTP DM6U9CQ MA Substrate DM6U9CQ RN Organic anion transporting polypeptide 1B1: a genetically polymorphic transporter of major importance for hepatic drug uptake. Pharmacol Rev. 2011 Mar;63(1):157-81. DM6U9CQ RU http://www.ncbi.nlm.nih.gov/pubmed/21245207 DM6U9CQ DI DM6U9CQ DM6U9CQ DN Pazopanib HCl DM6U9CQ MI DTUGYRD DM6U9CQ MN P-glycoprotein 1 (ABCB1) DM6U9CQ MT DTP DM6U9CQ MA Substrate DM6U9CQ RN Bioavailability, metabolism and disposition of oral pazopanib in patients with advanced cancer. Xenobiotica. 2013 May;43(5):443-53. DM6U9CQ RU http://www.ncbi.nlm.nih.gov/pubmed/23548165 DM6U9CQ DI DM6U9CQ DM6U9CQ DN Pazopanib HCl DM6U9CQ MI TTI2WET DM6U9CQ MN Platelet-derived growth factor receptor (PDGFR) DM6U9CQ MT DTT DM6U9CQ MA Inhibitor DM6U9CQ RN Hughes B: 2009 FDA drug approvals. 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DM49IGF RU https://pubmed.ncbi.nlm.nih.gov/3282749 DMOWEBU DI DMOWEBU DMOWEBU DN Pegaptanib DMOWEBU MI TTIPJCB DMOWEBU MN Neuropilin-1 (NRP1) DMOWEBU MT DTT DMOWEBU RN Pegaptanib, a targeted anti-VEGF aptamer for ocular vascular disease. Nat Rev Drug Discov. 2006 Feb;5(2):123-32. DMOWEBU RU https://pubmed.ncbi.nlm.nih.gov/16518379 DM7UP8X DI DM7UP8X DM7UP8X DN Pegfilgrastim DM7UP8X MI TTC70AJ DM7UP8X MN Granulocyte colony-stimulating factor receptor (G-CSF-R) DM7UP8X MT DTT DM7UP8X MA Binder DM7UP8X RN Evidence that the granulocyte colony-stimulating factor (G-CSF) receptor plays a role in the pharmacokinetics of G-CSF and PegG-CSF using a G-CSF-R KO model. Pharmacol Res. 2004 Jul;50(1):55-8. DM7UP8X RU https://pubmed.ncbi.nlm.nih.gov/15082029 DMJI3BA DI DMJI3BA DMJI3BA DN Peginterferon alfa-2a DMJI3BA MI TTSIUJ9 DMJI3BA MN Interferon-alpha 2 (IFNA2) DMJI3BA MT DTT DMJI3BA MA Modulator DMJI3BA RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. DMJI3BA RU https://www.fda.gov/ DMAP58Y DI DMAP58Y DMAP58Y DN Peginterferon alfa-2b DMAP58Y MI TTSIUJ9 DMAP58Y MN Interferon-alpha 2 (IFNA2) DMAP58Y MT DTT DMAP58Y MA Modulator DMAP58Y RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. DMAP58Y RU https://www.fda.gov/ DMCLR6G DI DMCLR6G DMCLR6G DN Pegloticase DMCLR6G MI TTZ1SWF DMCLR6G MN Uric acid (URA) DMCLR6G MT DTT DMCLR6G MA Modulator DMCLR6G RN Mullard A: 2010 FDA drug approvals. Nat Rev Drug Discov. 2011 Feb;10(2):82-5. DMCLR6G RU https://pubmed.ncbi.nlm.nih.gov/21283092 DM6NZ2P DI DM6NZ2P DM6NZ2P DN Pegvaliase DM6NZ2P MI TTGSVH2 DM6NZ2P MN Phenylalanine hydroxylase (PAH) DM6NZ2P MT DTT DM6NZ2P MA Modulator DM6NZ2P RN Induction, titration, and maintenance dosing regimen in a phase 2 study of pegvaliase for control of blood phenylalanine in adults with phenylketonuria.Mol Genet Metab. 2018 Nov;125(3):217-227. DM6NZ2P RU https://pubmed.ncbi.nlm.nih.gov/30146451 DMDEZI3 DI DMDEZI3 DMDEZI3 DN Pegvisomant DMDEZI3 MI TTKMAZ6 DMDEZI3 MN Growth hormone receptor (GHR) DMDEZI3 MT DTT DMDEZI3 MA Antagonist DMDEZI3 RN Growth hormone receptor antagonist treatment reduces exercise performance in young males. J Clin Endocrinol Metab. 2009 Sep;94(9):3265-72. DMDEZI3 RU https://pubmed.ncbi.nlm.nih.gov/19549743 DMRH0D5 DI DMRH0D5 DMRH0D5 DN PEGylated IFN beta 1-a DMRH0D5 MI TT4TZ8J DMRH0D5 MN Interferon-beta (IFNB1) DMRH0D5 MT DTT DMRH0D5 MA Modulator DMRH0D5 RN Pegylated interferon beta-1a for relapsing-remitting multiple sclerosis (ADVANCE): a randomised, phase 3, double-blind study. Lancet Neurol. 2014 Jul;13(7):657-65. DMRH0D5 RU https://pubmed.ncbi.nlm.nih.gov/24794721 DM8DQV9 DI DM8DQV9 DM8DQV9 DN Pelubiprofen DM8DQV9 MI TTK0943 DM8DQV9 MN Prostaglandin G/H synthase (COX) DM8DQV9 MT DTT DM8DQV9 MA Modulator DM8DQV9 RN Anti-inflammatory effect of pelubiprofen, 2-[4-(oxocyclohexylidenemethyl)-phenyl]propionic acid, mediated by dual suppression of COX activity and LPS-induced inflammatory gene expression via NF- B inactivation. J Cell Biochem. 2011 Dec;112(12):3594-603. DM8DQV9 RU https://pubmed.ncbi.nlm.nih.gov/21809372 DMD1VZL DI DMD1VZL DMD1VZL DN Pemafibrate DMD1VZL MI TTJ584C DMD1VZL MN Peroxisome proliferator-activated receptor alpha (PPARA) DMD1VZL MT DTT DMD1VZL MA Agonist DMD1VZL RN Pemafibrate: First Global Approval. Drugs. 2017 Oct;77(16):1805-1810. DMD1VZL RU https://pubmed.ncbi.nlm.nih.gov/28929345 DMFQEA6 DI DMFQEA6 DMFQEA6 DN Pembrolizumab DMFQEA6 MI TTNBFWK DMFQEA6 MN Programmed cell death protein 1 (PD-1) DMFQEA6 MT DTT DMFQEA6 RN Development of Inhibitors of the Programmed Cell Death-1/Programmed Cell Death-Ligand 1 Signaling Pathway.J Med Chem. 2019 Feb 28;62(4):1715-1730. DMFQEA6 RU https://pubmed.ncbi.nlm.nih.gov/30247903 DMMX2E6 DI DMMX2E6 DMMX2E6 DN Pemetrexed DMMX2E6 MI DTI7UX6 DMMX2E6 MN Breast cancer resistance protein (ABCG2) DMMX2E6 MT DTP DMMX2E6 MA Substrate DMMX2E6 RN pH-Dependent transport of pemetrexed by breast cancer resistance protein. Drug Metab Dispos. 2011 Sep;39(9):1478-85. DMMX2E6 RU https://doi.org/10.1124/dmd.111.039370 DMMX2E6 DI DMMX2E6 DMMX2E6 DN Pemetrexed DMMX2E6 MI TTU6BFZ DMMX2E6 MN Candida Thymidylate synthase (Candi TMP1) DMMX2E6 MT DTT DMMX2E6 MA Inhibitor DMMX2E6 RN Updated clinical information on multitargeted antifolates in lung cancer. Clin Lung Cancer. 2009 Mar;10 Suppl 1:S35-40. DMMX2E6 RU https://pubmed.ncbi.nlm.nih.gov/19362945 DMMX2E6 DI DMMX2E6 DMMX2E6 DN Pemetrexed DMMX2E6 MI DTOSN46 DMMX2E6 MN Folate transporter 1 (SLC19A1) DMMX2E6 MT DTP DMMX2E6 MA Substrate DMMX2E6 RN Biology of the major facilitative folate transporters SLC19A1 and SLC46A1. Curr Top Membr. 2014;73:175-204. DMMX2E6 RU http://www.ncbi.nlm.nih.gov/pubmed/24745983 DMMX2E6 DI DMMX2E6 DMMX2E6 DN Pemetrexed DMMX2E6 MI DTFI42L DMMX2E6 MN Multidrug resistance-associated protein 2 (ABCC2) DMMX2E6 MT DTP DMMX2E6 MA Substrate DMMX2E6 RN Human intestinal transporter database: QSAR modeling and virtual profiling of drug uptake, efflux and interactions. Pharm Res. 2013 Apr;30(4):996-1007. DMMX2E6 RU https://doi.org/10.1007/s11095-012-0935-x DMMX2E6 DI DMMX2E6 DMMX2E6 DN Pemetrexed DMMX2E6 MI DTYVM24 DMMX2E6 MN Multidrug resistance-associated protein 5 (ABCC5) DMMX2E6 MT DTP DMMX2E6 MA Substrate DMMX2E6 RN Kinetic validation of the use of carboxydichlorofluorescein as a drug surrogate for MRP5-mediated transport. Eur J Pharm Sci. 2006 Apr;27(5):524-32. DMMX2E6 RU http://www.ncbi.nlm.nih.gov/pubmed/16337112 DMMX2E6 DI DMMX2E6 DMMX2E6 DN Pemetrexed DMMX2E6 MI DTPFTEQ DMMX2E6 MN Organic anion transporting polypeptide 2B1 (SLCO2B1) DMMX2E6 MT DTP DMMX2E6 MA Substrate DMMX2E6 RN Substrate- and pH-specific antifolate transport mediated by organic anion-transporting polypeptide 2B1 (OATP2B1-SLCO2B1). Mol Pharmacol. 2012 Feb;81(2):134-42. DMMX2E6 RU https://doi.org/10.1124/mol.111.074823 DMMX2E6 DI DMMX2E6 DMMX2E6 DN Pemetrexed DMMX2E6 MI DTDJEMI DMMX2E6 MN Proton-coupled folate transporter (SLC46A1) DMMX2E6 MT DTP DMMX2E6 MA Substrate DMMX2E6 RN The proton-coupled folate transporter: impact on pemetrexed transport and on antifolates activities compared with the reduced folate carrier. Mol Pharmacol. 2008 Sep;74(3):854-62. DMMX2E6 RU http://www.ncbi.nlm.nih.gov/pubmed/18524888 DM819JF DI DM819JF DM819JF DN Pemigatinib DM819JF MI TTRLW2X DM819JF MN Fibroblast growth factor receptor 1 (FGFR1) DM819JF MT DTT DM819JF MA Inhibitor DM819JF RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health Human Services. 2020 DM819JF RU https://www.accessdata.fda.gov/drugsatfda_docs/label/2020/213736s000lbl.pdf DM819JF DI DM819JF DM819JF DN Pemigatinib DM819JF MI TTGJVQM DM819JF MN Fibroblast growth factor receptor 2 (FGFR2) DM819JF MT DTT DM819JF MA Inhibitor DM819JF RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health Human Services. 2020 DM819JF RU https://www.accessdata.fda.gov/drugsatfda_docs/label/2020/213736s000lbl.pdf DM819JF DI DM819JF DM819JF DN Pemigatinib DM819JF MI TTST7KB DM819JF MN Fibroblast growth factor receptor 3 (FGFR3) DM819JF MT DTT DM819JF MA Inhibitor DM819JF RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health Human Services. 2020 DM819JF RU https://www.accessdata.fda.gov/drugsatfda_docs/label/2020/213736s000lbl.pdf DML97WV DI DML97WV DML97WV DN Pemirolast DML97WV MI TTTIBOJ DML97WV MN Histamine H1 receptor (H1R) DML97WV MT DTT DML97WV MA Antagonist DML97WV RN The effect of a combined therapy with a histamine H1 antagonist and a chemical mediator release inhibitor on allergic conjunctivitis. Ophthalmologica. 2008;222(4):232-9. DML97WV RU https://pubmed.ncbi.nlm.nih.gov/18463425 DML97WV DI DML97WV DML97WV DN Pemirolast DML97WV MI DTFI42L DML97WV MN Multidrug resistance-associated protein 2 (ABCC2) DML97WV MT DTP DML97WV MA Substrate DML97WV RN Human intestinal transporter database: QSAR modeling and virtual profiling of drug uptake, efflux and interactions. Pharm Res. 2013 Apr;30(4):996-1007. DML97WV RU https://doi.org/10.1007/s11095-012-0935-x DML97WV DI DML97WV DML97WV DN Pemirolast DML97WV MI DTUGYRD DML97WV MN P-glycoprotein 1 (ABCB1) DML97WV MT DTP DML97WV MA Substrate DML97WV RN Human intestinal transporter database: QSAR modeling and virtual profiling of drug uptake, efflux and interactions. Pharm Res. 2013 Apr;30(4):996-1007. DML97WV RU https://doi.org/10.1007/s11095-012-0935-x DM4ES8F DI DM4ES8F DM4ES8F DN Penbutolol DM4ES8F MI TTR6W5O DM4ES8F MN Adrenergic receptor beta-1 (ADRB1) DM4ES8F MT DTT DM4ES8F MA Antagonist DM4ES8F RN beta-Adrenergic receptor blockers--a group of chiral drugs: different effects of each enantiomer. Ceska Slov Farm. 2002 May;51(3):121-8. DM4ES8F RU https://pubmed.ncbi.nlm.nih.gov/12058352 DM4ES8F DI DM4ES8F DM4ES8F DN Penbutolol DM4ES8F MI DECB0K3 DM4ES8F MN Cytochrome P450 2D6 (CYP2D6) DM4ES8F MT DME DM4ES8F MA Metabolism DM4ES8F RN Application of substrate depletion assay to evaluation of CYP isoforms responsible for stereoselective metabolism of carvedilol. Drug Metab Pharmacokinet. 2016 Dec;31(6):425-432. DM4ES8F RU https://www.ncbi.nlm.nih.gov/pubmed/?term=27836712 DMOUMDV DI DMOUMDV DMOUMDV DN Penciclovir DMOUMDV MI TTIU7X1 DMOUMDV MN Herpes simplex virus DNA polymerase UL30 (HSV UL30) DMOUMDV MT DTT DMOUMDV MA Inhibitor DMOUMDV RN Antimicrobial strategies: inhibition of viral polymerases by 3'-hydroxyl nucleosides. Drugs. 2009;69(2):151-66. DMOUMDV RU https://pubmed.ncbi.nlm.nih.gov/19228073 DMOUMDV DI DMOUMDV DMOUMDV DN Penciclovir DMOUMDV MI DT0OC1Q DMOUMDV MN Organic anion transporter 2 (SLC22A7) DMOUMDV MT DTP DMOUMDV MA Substrate DMOUMDV RN In vitro studies with two human organic anion transporters: OAT2 and OAT7. Xenobiotica. 2018 Oct;48(10):1037-1049. DMOUMDV RU http://www.ncbi.nlm.nih.gov/pubmed/28945155 DMOUMDV DI DMOUMDV DMOUMDV DN Penciclovir DMOUMDV MI TTP3QRF DMOUMDV MN Thymidine kinase 1 (TK1) DMOUMDV MT DTT DMOUMDV MA Inhibitor DMOUMDV RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMOUMDV RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMG1DTE DI DMG1DTE DMG1DTE DN Penfluridol DMG1DTE MI TT729IR DMG1DTE MN Voltage-gated calcium channel alpha Cav3.1 (CACNA1G) DMG1DTE MT DTT DMG1DTE MA Blocker DMG1DTE RN Differential inhibition of T-type calcium channels by neuroleptics. J Neurosci. 2002 Jan 15;22(2):396-403. DMG1DTE RU https://pubmed.ncbi.nlm.nih.gov/11784784 DM40EF6 DI DM40EF6 DM40EF6 DN Penicillamine DM40EF6 MI TTT3ZC9 DM40EF6 MN Human immunodeficiency virus Tat protein (HIV tat) DM40EF6 MT DTT DM40EF6 MA Inhibitor DM40EF6 RN Docking studies reveal a selective binding of D-penicillamine to the transactivator protein of human immunodeficiency virus type 1. FEBS Lett. 2002 Apr 10;516(1-3):43-6. DM40EF6 RU https://pubmed.ncbi.nlm.nih.gov/11959100 DMNMHBV DI DMNMHBV DMNMHBV DN Penicillin DMNMHBV MI TTJP4SM DMNMHBV MN Bacterial Penicillin binding protein (Bact PBP) DMNMHBV MT DTT DMNMHBV MA Modulator DMNMHBV RN Bacterial Resistance to Penicillin G by Decreased Affinity of Penicillin-Binding Proteins: A Mathematical Model DMNMHBV RU https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2957969 DM49VEW DI DM49VEW DM49VEW DN Penicillin G Benzathine DM49VEW MI TTJP4SM DM49VEW MN Bacterial Penicillin binding protein (Bact PBP) DM49VEW MT DTT DM49VEW MA Modulator DM49VEW RN Bacterial Resistance to Penicillin G by Decreased Affinity of Penicillin-Binding Proteins: A Mathematical Model DM49VEW RU https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2957969 DMU4JLB DI DMU4JLB DMU4JLB DN Penicillin G Procaine DMU4JLB MI TTJP4SM DMU4JLB MN Bacterial Penicillin binding protein (Bact PBP) DMU4JLB MT DTT DMU4JLB MA Modulator DMU4JLB RN Bacterial Resistance to Penicillin G by Decreased Affinity of Penicillin-Binding Proteins: A Mathematical Model DMU4JLB RU https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2957969 DMY18XK DI DMY18XK DMY18XK DN Penicillin G Sodium DMY18XK MI TTJP4SM DMY18XK MN Bacterial Penicillin binding protein (Bact PBP) DMY18XK MT DTT DMY18XK MA Modulator DMY18XK RN Bacterial Resistance to Penicillin G by Decreased Affinity of Penicillin-Binding Proteins: A Mathematical Model DMY18XK RU https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2957969 DMKVOYF DI DMKVOYF DMKVOYF DN Penicillin V DMKVOYF MI TTJP4SM DMKVOYF MN Bacterial Penicillin binding protein (Bact PBP) DMKVOYF MT DTT DMKVOYF MA Binder DMKVOYF RN Localization of penicillin-binding proteins to the splitting system of Staphylococcus aureus septa by using a mercury-penicillin V derivative. J Bacteriol. 1995 Jul;177(13):3631-40. DMKVOYF RU https://pubmed.ncbi.nlm.nih.gov/7541399 DM8LX76 DI DM8LX76 DM8LX76 DN Penicillin V Potassium DM8LX76 MI TTJP4SM DM8LX76 MN Bacterial Penicillin binding protein (Bact PBP) DM8LX76 MT DTT DM8LX76 MA Modulator DM8LX76 RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. DM8LX76 RU https://www.fda.gov/ DMZ9MO5 DI DMZ9MO5 DMZ9MO5 DN Pentaerythritol tetranitrate DMZ9MO5 MI DEWYTJB DMZ9MO5 MN Aldehyde dehydrogenase 2 (ALDH2) DMZ9MO5 MT DME DMZ9MO5 MA Metabolism DMZ9MO5 RN OSHA Occupational Chemical Database: drug information. DMZ9MO5 RU https://www.osha.gov/dts/chemicalsampling/data/CH_260110.html DMRCLZB DI DMRCLZB DMRCLZB DN Pentagastrin DMRCLZB MI TTVFO0U DMRCLZB MN Gastrin/cholecystokinin type B receptor (CCKBR) DMRCLZB MT DTT DMRCLZB MA Agonist DMRCLZB RN Functional interactions between endocannabinoid and CCK neurotransmitter systems may be critical for extinction learning. Neuropsychopharmacology. 2009 Jan;34(2):509-21. DMRCLZB RU https://pubmed.ncbi.nlm.nih.gov/18580872 DMHZJCG DI DMHZJCG DMHZJCG DN Pentamidine DMHZJCG MI DEJGDUW DMHZJCG MN Cytochrome P450 1A2 (CYP1A2) DMHZJCG MT DME DMHZJCG MA Metabolism DMHZJCG RN Identification of human cytochrome P(450)s that metabolise anti-parasitic drugs and predictions of in vivo drug hepatic clearance from in vitro data. Eur J Clin Pharmacol. 2003 Sep;59(5-6):429-42. DMHZJCG RU https://www.ncbi.nlm.nih.gov/pubmed/?term=12920490 DMHZJCG DI DMHZJCG DMHZJCG DN Pentamidine DMHZJCG MI DES5XRU DMHZJCG MN Cytochrome P450 2C8 (CYP2C8) DMHZJCG MT DME DMHZJCG MA Metabolism DMHZJCG RN Identification of human cytochrome P(450)s that metabolise anti-parasitic drugs and predictions of in vivo drug hepatic clearance from in vitro data. Eur J Clin Pharmacol. 2003 Sep;59(5-6):429-42. DMHZJCG RU https://www.ncbi.nlm.nih.gov/pubmed/?term=12920490 DMHZJCG DI DMHZJCG DMHZJCG DN Pentamidine DMHZJCG MI DECB0K3 DMHZJCG MN Cytochrome P450 2D6 (CYP2D6) DMHZJCG MT DME DMHZJCG MA Metabolism DMHZJCG RN Identification of human cytochrome P(450)s that metabolise anti-parasitic drugs and predictions of in vivo drug hepatic clearance from in vitro data. Eur J Clin Pharmacol. 2003 Sep;59(5-6):429-42. DMHZJCG RU https://www.ncbi.nlm.nih.gov/pubmed/?term=12920490 DMHZJCG DI DMHZJCG DMHZJCG DN Pentamidine DMHZJCG MI DE4LYSA DMHZJCG MN Cytochrome P450 3A4 (CYP3A4) DMHZJCG MT DME DMHZJCG MA Metabolism DMHZJCG RN Identification of human cytochrome P(450)s that metabolise anti-parasitic drugs and predictions of in vivo drug hepatic clearance from in vitro data. Eur J Clin Pharmacol. 2003 Sep;59(5-6):429-42. DMHZJCG RU https://www.ncbi.nlm.nih.gov/pubmed/?term=12920490 DMHZJCG DI DMHZJCG DMHZJCG DN Pentamidine DMHZJCG MI DEIBDNY DMHZJCG MN Cytochrome P450 3A5 (CYP3A5) DMHZJCG MT DME DMHZJCG MA Metabolism DMHZJCG RN Identification of human cytochrome P(450)s that metabolise anti-parasitic drugs and predictions of in vivo drug hepatic clearance from in vitro data. Eur J Clin Pharmacol. 2003 Sep;59(5-6):429-42. DMHZJCG RU https://www.ncbi.nlm.nih.gov/pubmed/?term=12920490 DMHZJCG DI DMHZJCG DMHZJCG DN Pentamidine DMHZJCG MI DEGTFWK DMHZJCG MN Mephenytoin 4-hydroxylase (CYP2C19) DMHZJCG MT DME DMHZJCG MA Metabolism DMHZJCG RN Value of preemptive CYP2C19 genotyping in allogeneic stem cell transplant patients considered for pentamidine administration. Clin Transplant. 2011 May-Jun;25(3):E271-5. DMHZJCG RU https://www.ncbi.nlm.nih.gov/pubmed/?term=21299635 DMHZJCG DI DMHZJCG DMHZJCG DN Pentamidine DMHZJCG MI DTT79CX DMHZJCG MN Organic cation transporter 1 (SLC22A1) DMHZJCG MT DTP DMHZJCG MA Substrate DMHZJCG RN Transport of dicationic drugs pentamidine and furamidine by human organic cation transporters. Drug Metab Dispos. 2009 Feb;37(2):424-30. DMHZJCG RU http://www.ncbi.nlm.nih.gov/pubmed/18971316 DMHZJCG DI DMHZJCG DMHZJCG DN Pentamidine DMHZJCG MI TTM1TDX DMHZJCG MN Tryptase alpha/beta-1 (Tryptase) DMHZJCG MT DTT DMHZJCG MA Inhibitor DMHZJCG RN Inhibitors of tryptase for the treatment of mast cell-mediated diseases. Curr Pharm Des. 1998 Oct;4(5):381-96. DMHZJCG RU https://pubmed.ncbi.nlm.nih.gov/10197050 DM1XBHS DI DM1XBHS DM1XBHS DN Pentazocine DM1XBHS MI TTN4QDT DM1XBHS MN Opioid receptor (OPR) DM1XBHS MT DTT DM1XBHS MA Antagonist DM1XBHS RN Functional characterization of a sigma receptor and its gene expression by haloperidol. Nippon Yakurigaku Zasshi. 1999 Jul;114(1):61-8. DM1XBHS RU https://pubmed.ncbi.nlm.nih.gov/10562966 DM1XBHS DI DM1XBHS DM1XBHS DN Pentazocine DM1XBHS MI DTUGYRD DM1XBHS MN P-glycoprotein 1 (ABCB1) DM1XBHS MT DTP DM1XBHS MA Substrate DM1XBHS RN Mammalian drug efflux transporters of the ATP binding cassette (ABC) family in multidrug resistance: A review of the past decade. Cancer Lett. 2016 Jan 1;370(1):153-64. DM1XBHS RU http://www.ncbi.nlm.nih.gov/pubmed/26499806 DMFNH7L DI DMFNH7L DMFNH7L DN Pentobarbital DMFNH7L MI TT1MPAY DMFNH7L MN GABA(A) receptor alpha-1 (GABRA1) DMFNH7L MT DTT DMFNH7L MA Antagonist DMFNH7L RN DrugBank: a knowledgebase for drugs, drug actions and drug targets. Nucleic Acids Res. 2008 Jan;36(Database issue):D901-6. DMFNH7L RU https://pubmed.ncbi.nlm.nih.gov/18048412 DMFNH7L DI DMFNH7L DMFNH7L DN Pentobarbital DMFNH7L MI DEGTFWK DMFNH7L MN Mephenytoin 4-hydroxylase (CYP2C19) DMFNH7L MT DME DMFNH7L MA Metabolism DMFNH7L RN CYP2C19 polymorphism effect on phenobarbitone. Pharmacokinetics in Japanese patients with epilepsy: analysis by population pharmacokinetics. Eur J Clin Pharmacol. 2000 Feb-Mar;55(11-12):821-5. DMFNH7L RU https://www.ncbi.nlm.nih.gov/pubmed/?term=10805060 DM38VYQ DI DM38VYQ DM38VYQ DN Pentolinium DM38VYQ MI TT4H1MQ DM38VYQ MN Neuronal acetylcholine receptor alpha-4 (CHRNA4) DM38VYQ MT DTT DM38VYQ MA Antagonist DM38VYQ RN Nicotinic and nonnicotinic receptor-mediated actions of vinblastine. Proc Soc Exp Biol Med. 1993 Jul;203(3):372-6. DM38VYQ RU https://pubmed.ncbi.nlm.nih.gov/8516349 DM2HRKE DI DM2HRKE DM2HRKE DN Pentosan polysulfate DM2HRKE MI TTCEKVZ DM2HRKE MN Fibroblast growth factor-4 (FGF4) DM2HRKE MT DTT DM2HRKE MA Modulator DM2HRKE RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. DM2HRKE RU https://www.fda.gov/ DM0HXDS DI DM0HXDS DM0HXDS DN Pentostatin DM0HXDS MI TTLP57V DM0HXDS MN Adenosine deaminase (ADA) DM0HXDS MT DTT DM0HXDS MA Inhibitor DM0HXDS RN Purine nucleoside analogs in indolent non-Hodgkin's lymphoma. Oncology (Williston Park). 2000 Jun;14(6 Suppl 2):13-5. DM0HXDS RU https://pubmed.ncbi.nlm.nih.gov/10887639 DMU3DNC DI DMU3DNC DMU3DNC DN Pentoxifylline DMU3DNC MI DEJGDUW DMU3DNC MN Cytochrome P450 1A2 (CYP1A2) DMU3DNC MT DME DMU3DNC MA Metabolism DMU3DNC RN Cytochrome P450 isozymes involved in lisofylline metabolism to pentoxifylline in human liver microsomes. Drug Metab Dispos. 1997 Dec;25(12):1354-8. DMU3DNC RU https://www.ncbi.nlm.nih.gov/pubmed/?term=9394024 DMU3DNC DI DMU3DNC DMU3DNC DN Pentoxifylline DMU3DNC MI TTF8CQI DMU3DNC MN Tumor necrosis factor (TNF) DMU3DNC MT DTT DMU3DNC RN Targeted therapies in myelodysplastic syndromes: ASH 2003 review. Semin Hematol. 2004 Apr;41(2 Suppl 4):13-20. DMU3DNC RU https://pubmed.ncbi.nlm.nih.gov/15190511 DMNXY5K DI DMNXY5K DMNXY5K DN Peramivir DMNXY5K MI TT50QJ3 DMNXY5K MN Influenza Neuraminidase (Influ NA) DMNXY5K MT DTT DMNXY5K MA Inhibitor DMNXY5K RN Developing new antiviral agents for influenza treatment: what does the future hold Clin Infect Dis. 2009 Jan 1;48 Suppl 1:S3-13. DMNXY5K RU https://pubmed.ncbi.nlm.nih.gov/19067613 DM2AOTZ DI DM2AOTZ DM2AOTZ DN Perazine DM2AOTZ MI DE6OQ3W DM2AOTZ MN Cytochrome P450 1A1 (CYP1A1) DM2AOTZ MT DME DM2AOTZ MA Metabolism DM2AOTZ RN The metabolism of the piperazine-type phenothiazine neuroleptic perazine by the human cytochrome P-450 isoenzymes. Eur Neuropsychopharmacol. 2004 May;14(3):199-208. DM2AOTZ RU https://www.ncbi.nlm.nih.gov/pubmed/?term=15056479 DM2AOTZ DI DM2AOTZ DM2AOTZ DN Perazine DM2AOTZ MI DEJGDUW DM2AOTZ MN Cytochrome P450 1A2 (CYP1A2) DM2AOTZ MT DME DM2AOTZ MA Metabolism DM2AOTZ RN Perazine as a potent inhibitor of human CYP1A2 but not CYP3A4. Pol J Pharmacol. 2002 Jul-Aug;54(4):407-10. DM2AOTZ RU https://www.ncbi.nlm.nih.gov/pubmed/?term=12523495 DM2AOTZ DI DM2AOTZ DM2AOTZ DN Perazine DM2AOTZ MI DEJVYAZ DM2AOTZ MN Cytochrome P450 2A6 (CYP2A6) DM2AOTZ MT DME DM2AOTZ MA Metabolism DM2AOTZ RN The metabolism of the piperazine-type phenothiazine neuroleptic perazine by the human cytochrome P-450 isoenzymes. Eur Neuropsychopharmacol. 2004 May;14(3):199-208. DM2AOTZ RU https://www.ncbi.nlm.nih.gov/pubmed/?term=15056479 DM2AOTZ DI DM2AOTZ DM2AOTZ DN Perazine DM2AOTZ MI DE5IED8 DM2AOTZ MN Cytochrome P450 2C9 (CYP2C9) DM2AOTZ MT DME DM2AOTZ MA Metabolism DM2AOTZ RN Cytochrome P-450 enzymes and FMO3 contribute to the disposition of the antipsychotic drug perazine in vitro. Psychopharmacology (Berl). 2000 Sep;151(4):312-20. DM2AOTZ RU https://www.ncbi.nlm.nih.gov/pubmed/?term=11026737 DM2AOTZ DI DM2AOTZ DM2AOTZ DN Perazine DM2AOTZ MI DECB0K3 DM2AOTZ MN Cytochrome P450 2D6 (CYP2D6) DM2AOTZ MT DME DM2AOTZ MA Metabolism DM2AOTZ RN Cytochrome P-450 enzymes and FMO3 contribute to the disposition of the antipsychotic drug perazine in vitro. Psychopharmacology (Berl). 2000 Sep;151(4):312-20. DM2AOTZ RU https://www.ncbi.nlm.nih.gov/pubmed/?term=11026737 DM2AOTZ DI DM2AOTZ DM2AOTZ DN Perazine DM2AOTZ MI DEVDYN7 DM2AOTZ MN Cytochrome P450 2E1 (CYP2E1) DM2AOTZ MT DME DM2AOTZ MA Metabolism DM2AOTZ RN Effects of phenothiazine neuroleptics on the rate of caffeine demethylation and hydroxylation in the rat liver. Pol J Pharmacol. 2001 Nov-Dec;53(6):615-21. DM2AOTZ RU https://www.ncbi.nlm.nih.gov/pubmed/?term=11985335 DM2AOTZ DI DM2AOTZ DM2AOTZ DN Perazine DM2AOTZ MI DE4LYSA DM2AOTZ MN Cytochrome P450 3A4 (CYP3A4) DM2AOTZ MT DME DM2AOTZ MA Metabolism DM2AOTZ RN The metabolism of the piperazine-type phenothiazine neuroleptic perazine by the human cytochrome P-450 isoenzymes. Eur Neuropsychopharmacol. 2004 May;14(3):199-208. DM2AOTZ RU https://www.ncbi.nlm.nih.gov/pubmed/?term=15056479 DM2AOTZ DI DM2AOTZ DM2AOTZ DN Perazine DM2AOTZ MI TTEX248 DM2AOTZ MN Dopamine D2 receptor (D2R) DM2AOTZ MT DTT DM2AOTZ MA Modulator DM2AOTZ RN Synthesis and in vitro binding of N-phenyl piperazine analogs as potential dopamine D3 receptor ligands. Bioorg Med Chem. 2005 Jan 3;13(1):77-87. DM2AOTZ RU https://pubmed.ncbi.nlm.nih.gov/15582454 DM2AOTZ DI DM2AOTZ DM2AOTZ DN Perazine DM2AOTZ MI DEGTFWK DM2AOTZ MN Mephenytoin 4-hydroxylase (CYP2C19) DM2AOTZ MT DME DM2AOTZ MA Metabolism DM2AOTZ RN Cytochrome P-450 enzymes and FMO3 contribute to the disposition of the antipsychotic drug perazine in vitro. Psychopharmacology (Berl). 2000 Sep;151(4):312-20. DM2AOTZ RU https://www.ncbi.nlm.nih.gov/pubmed/?term=11026737 DM2AOTZ DI DM2AOTZ DM2AOTZ DN Perazine DM2AOTZ MI DTUGYRD DM2AOTZ MN P-glycoprotein 1 (ABCB1) DM2AOTZ MT DTP DM2AOTZ MA Substrate DM2AOTZ RN Identification of P-glycoprotein substrates and inhibitors among psychoactive compounds--implications for pharmacokinetics of selected substrates. J Pharm Pharmacol. 2004 Aug;56(8):967-75. DM2AOTZ RU http://www.ncbi.nlm.nih.gov/pubmed/15285840 DM14MAE DI DM14MAE DM14MAE DN Pergolide DM14MAE MI TTZFYLI DM14MAE MN Dopamine D1 receptor (D1R) DM14MAE MT DTT DM14MAE MA Modulator DM14MAE RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. DM14MAE RU https://www.fda.gov/ DM14MAE DI DM14MAE DM14MAE DN Pergolide DM14MAE MI TTEX248 DM14MAE MN Dopamine D2 receptor (D2R) DM14MAE MT DTT DM14MAE MA Modulator DM14MAE RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. DM14MAE RU https://www.fda.gov/ DM5GKOV DI DM5GKOV DM5GKOV DN Pergolide mesylate DM5GKOV MI DE4LYSA DM5GKOV MN Cytochrome P450 3A4 (CYP3A4) DM5GKOV MT DME DM5GKOV MA Metabolism DM5GKOV RN Receptor-binding and pharmacokinetic properties of dopaminergic agonists. Curr Top Med Chem. 2008;8(12):1049-67. DM5GKOV RU https://www.ncbi.nlm.nih.gov/pubmed/?term=18691132 DMINO7Z DI DMINO7Z DMINO7Z DN Perhexiline DMINO7Z MI TTDL0NY DMINO7Z MN Carnitine O-palmitoyltransferase I (CPT1B) DMINO7Z MT DTT DMINO7Z MA Inhibitor DMINO7Z RN Perhexiline. Cardiovasc Drug Rev. 2007 Spring;25(1):76-97. DMINO7Z RU https://pubmed.ncbi.nlm.nih.gov/17445089 DMINO7Z DI DMINO7Z DMINO7Z DN Perhexiline DMINO7Z MI DEPKLMQ DMINO7Z MN Cytochrome P450 2B6 (CYP2B6) DMINO7Z MT DME DMINO7Z MA Metabolism DMINO7Z RN CYP2B6, CYP2D6, and CYP3A4 catalyze the primary oxidative metabolism of perhexiline enantiomers by human liver microsomes. Drug Metab Dispos. 2007 Jan;35(1):128-38. DMINO7Z RU https://www.ncbi.nlm.nih.gov/pubmed/?term=17050648 DMINO7Z DI DMINO7Z DMINO7Z DN Perhexiline DMINO7Z MI DECB0K3 DMINO7Z MN Cytochrome P450 2D6 (CYP2D6) DMINO7Z MT DME DMINO7Z MA Metabolism DMINO7Z RN CYP2B6, CYP2D6, and CYP3A4 catalyze the primary oxidative metabolism of perhexiline enantiomers by human liver microsomes. Drug Metab Dispos. 2007 Jan;35(1):128-38. DMINO7Z RU https://www.ncbi.nlm.nih.gov/pubmed/?term=17050648 DMINO7Z DI DMINO7Z DMINO7Z DN Perhexiline DMINO7Z MI DE4LYSA DMINO7Z MN Cytochrome P450 3A4 (CYP3A4) DMINO7Z MT DME DMINO7Z MA Metabolism DMINO7Z RN CYP2B6, CYP2D6, and CYP3A4 catalyze the primary oxidative metabolism of perhexiline enantiomers by human liver microsomes. Drug Metab Dispos. 2007 Jan;35(1):128-38. DMINO7Z RU https://www.ncbi.nlm.nih.gov/pubmed/?term=17050648 DMOPZDT DI DMOPZDT DMOPZDT DN Perindopril DMOPZDT MI TTL69WB DMOPZDT MN Angiotensin-converting enzyme (ACE) DMOPZDT MT DTT DMOPZDT MA Inhibitor DMOPZDT RN Fixed combination perindopril-amlodipine (Coveram) in the treatment of hypertension and coronary heart disease. Rev Med Liege. 2009 Apr;64(4):223-7. DMOPZDT RU https://pubmed.ncbi.nlm.nih.gov/19514543 DMOPZDT DI DMOPZDT DMOPZDT DN Perindopril DMOPZDT MI DT9G7XN DMOPZDT MN Peptide transporter 1 (SLC15A1) DMOPZDT MT DTP DMOPZDT MA Substrate DMOPZDT RN Transport of angiotensin-converting enzyme inhibitors by H+/peptide transporters revisited. J Pharmacol Exp Ther. 2008 Nov;327(2):432-41. DMOPZDT RU http://www.ncbi.nlm.nih.gov/pubmed/18713951 DMOPZDT DI DMOPZDT DMOPZDT DN Perindopril DMOPZDT MI DT8QKNP DMOPZDT MN Peptide transporter 2 (SLC15A2) DMOPZDT MT DTP DMOPZDT MA Substrate DMOPZDT RN Transport of angiotensin-converting enzyme inhibitors by H+/peptide transporters revisited. J Pharmacol Exp Ther. 2008 Nov;327(2):432-41. DMOPZDT RU http://www.ncbi.nlm.nih.gov/pubmed/18713951 DMZ0Q1G DI DMZ0Q1G DMZ0Q1G DN Permethrin DMZ0Q1G MI DEPKLMQ DMZ0Q1G MN Cytochrome P450 2B6 (CYP2B6) DMZ0Q1G MT DME DMZ0Q1G MA Metabolism DMZ0Q1G RN Human metabolic interactions of environmental chemicals. J Biochem Mol Toxicol. 2007;21(4):182-6. DMZ0Q1G RU https://www.ncbi.nlm.nih.gov/pubmed/?term=17936932 DMZ0Q1G DI DMZ0Q1G DMZ0Q1G DN Permethrin DMZ0Q1G MI DE4LYSA DMZ0Q1G MN Cytochrome P450 3A4 (CYP3A4) DMZ0Q1G MT DME DMZ0Q1G MA Metabolism DMZ0Q1G RN Human metabolic interactions of environmental chemicals. J Biochem Mol Toxicol. 2007;21(4):182-6. DMZ0Q1G RU https://www.ncbi.nlm.nih.gov/pubmed/?term=17936932 DMZ0Q1G DI DMZ0Q1G DMZ0Q1G DN Permethrin DMZ0Q1G MI TTRK8B9 DMZ0Q1G MN Sodium channel unspecific (NaC) DMZ0Q1G MT DTT DMZ0Q1G MA Blocker DMZ0Q1G RN In vitro assays for repellents and deterrents for ticks: differing effects of products when tested with attractant or arrestment stimuli. Med Vet Entomol. 2003 Dec;17(4):370-8. DMZ0Q1G RU https://pubmed.ncbi.nlm.nih.gov/14651650 DMVHJLX DI DMVHJLX DMVHJLX DN Perospirone DMVHJLX MI TTYSN63 DMVHJLX MN 5-HT 2 receptor (5HT2R) DMVHJLX MT DTT DMVHJLX MA Modulator DMVHJLX RN Pharmacological effects of zotepine and other antipsychotics on the central 5-HT2 receptors. Pharmacopsychiatry. 1993 Mar;26(2):53-8. DMVHJLX RU https://pubmed.ncbi.nlm.nih.gov/7690975 DMVHJLX DI DMVHJLX DMVHJLX DN Perospirone DMVHJLX MI DES5XRU DMVHJLX MN Cytochrome P450 2C8 (CYP2C8) DMVHJLX MT DME DMVHJLX MA Metabolism DMVHJLX RN Steady-state pharmacokinetics of a new antipsychotic agent perospirone and its active metabolite, and its relationship with prolactin response. Ther Drug Monit. 2004 Aug;26(4):361-5. DMVHJLX RU https://www.ncbi.nlm.nih.gov/pubmed/?term=15257064 DMVHJLX DI DMVHJLX DMVHJLX DN Perospirone DMVHJLX MI DECB0K3 DMVHJLX MN Cytochrome P450 2D6 (CYP2D6) DMVHJLX MT DME DMVHJLX MA Metabolism DMVHJLX RN Steady-state pharmacokinetics of a new antipsychotic agent perospirone and its active metabolite, and its relationship with prolactin response. Ther Drug Monit. 2004 Aug;26(4):361-5. DMVHJLX RU https://www.ncbi.nlm.nih.gov/pubmed/?term=15257064 DMA4MRX DI DMA4MRX DMA4MRX DN Perphenazine DMA4MRX MI DEJGDUW DMA4MRX MN Cytochrome P450 1A2 (CYP1A2) DMA4MRX MT DME DMA4MRX MA Metabolism DMA4MRX RN Effect of antipsychotic drugs on human liver cytochrome P-450 (CYP) isoforms in vitro: preferential inhibition of CYP2D6. Drug Metab Dispos. 1999 Sep;27(9):1078-84. DMA4MRX RU https://www.ncbi.nlm.nih.gov/pubmed/?term=10460810 DMA4MRX DI DMA4MRX DMA4MRX DN Perphenazine DMA4MRX MI DEZMWRE DMA4MRX MN Cytochrome P450 2C18 (CYP2C18) DMA4MRX MT DME DMA4MRX MA Metabolism DMA4MRX RN Identification of the human cytochrome P450 isoforms mediating in vitro N-dealkylation of perphenazine. Br J Clin Pharmacol. 2000 Dec;50(6):563-71. DMA4MRX RU https://www.ncbi.nlm.nih.gov/pubmed/?term=11136295 DMA4MRX DI DMA4MRX DMA4MRX DN Perphenazine DMA4MRX MI DES5XRU DMA4MRX MN Cytochrome P450 2C8 (CYP2C8) DMA4MRX MT DME DMA4MRX MA Metabolism DMA4MRX RN Identification of the human cytochrome P450 isoforms mediating in vitro N-dealkylation of perphenazine. Br J Clin Pharmacol. 2000 Dec;50(6):563-71. DMA4MRX RU https://www.ncbi.nlm.nih.gov/pubmed/?term=11136295 DMA4MRX DI DMA4MRX DMA4MRX DN Perphenazine DMA4MRX MI DE5IED8 DMA4MRX MN Cytochrome P450 2C9 (CYP2C9) DMA4MRX MT DME DMA4MRX MA Metabolism DMA4MRX RN Identification of the human cytochrome P450 isoforms mediating in vitro N-dealkylation of perphenazine. Br J Clin Pharmacol. 2000 Dec;50(6):563-71. DMA4MRX RU https://www.ncbi.nlm.nih.gov/pubmed/?term=11136295 DMA4MRX DI DMA4MRX DMA4MRX DN Perphenazine DMA4MRX MI DECB0K3 DMA4MRX MN Cytochrome P450 2D6 (CYP2D6) DMA4MRX MT DME DMA4MRX MA Metabolism DMA4MRX RN Use of antidepressant drugs in schizophrenic patients with depression. Encephale. 2006 Mar-Apr;32(2 Pt 1):263-9. DMA4MRX RU https://www.ncbi.nlm.nih.gov/pubmed/?term=16910628 DMA4MRX DI DMA4MRX DMA4MRX DN Perphenazine DMA4MRX MI DE4LYSA DMA4MRX MN Cytochrome P450 3A4 (CYP3A4) DMA4MRX MT DME DMA4MRX MA Metabolism DMA4MRX RN Identification of the human cytochrome P450 isoforms mediating in vitro N-dealkylation of perphenazine. Br J Clin Pharmacol. 2000 Dec;50(6):563-71. DMA4MRX RU https://www.ncbi.nlm.nih.gov/pubmed/?term=11136295 DMA4MRX DI DMA4MRX DMA4MRX DN Perphenazine DMA4MRX MI TTEX248 DMA4MRX MN Dopamine D2 receptor (D2R) DMA4MRX MT DTT DMA4MRX MA Antagonist DMA4MRX RN CYP2D6 and DRD2 genes differentially impact pharmacodynamic sensitivity and time course of prolactin response to perphenazine. Pharmacogenet Genomics. 2007 Nov;17(11):989-93. DMA4MRX RU https://pubmed.ncbi.nlm.nih.gov/18075468 DMA4MRX DI DMA4MRX DMA4MRX DN Perphenazine DMA4MRX MI DEGTFWK DMA4MRX MN Mephenytoin 4-hydroxylase (CYP2C19) DMA4MRX MT DME DMA4MRX MA Metabolism DMA4MRX RN Identification of the human cytochrome P450 isoforms mediating in vitro N-dealkylation of perphenazine. Br J Clin Pharmacol. 2000 Dec;50(6):563-71. DMA4MRX RU https://www.ncbi.nlm.nih.gov/pubmed/?term=11136295 DMA4MRX DI DMA4MRX DMA4MRX DN Perphenazine DMA4MRX MI DTT79CX DMA4MRX MN Organic cation transporter 1 (SLC22A1) DMA4MRX MT DTP DMA4MRX MA Substrate DMA4MRX RN Identification of novel substrates and structure-activity relationship of cellular uptake mediated by human organic cation transporters 1 and 2. J Med Chem. 2013 Sep 26;56(18):7232-42. DMA4MRX RU http://www.ncbi.nlm.nih.gov/pubmed/23984907 DMA4MRX DI DMA4MRX DMA4MRX DN Perphenazine DMA4MRX MI DTUGYRD DMA4MRX MN P-glycoprotein 1 (ABCB1) DMA4MRX MT DTP DMA4MRX MA Substrate DMA4MRX RN Identification of P-glycoprotein substrates and inhibitors among psychoactive compounds--implications for pharmacokinetics of selected substrates. J Pharm Pharmacol. 2004 Aug;56(8):967-75. DMA4MRX RU http://www.ncbi.nlm.nih.gov/pubmed/15285840 DMHJV0X DI DMHJV0X DMHJV0X DN Pertuzumab DMHJV0X MI TT6EO5L DMHJV0X MN Erbb2 tyrosine kinase receptor (HER2) DMHJV0X MT DTT DMHJV0X MA Inhibitor DMHJV0X RN Clinical pipeline report, company report or official report of Roche (2009). DMHJV0X RU http://www.roche.com/research_and_development/pipeline/roche_pharma_pipeline.htm DMS2J0Z DI DMS2J0Z DMS2J0Z DN Pexidartinib DMS2J0Z MI TTGJCWZ DMS2J0Z MN Fms-like tyrosine kinase 3 (FLT-3) DMS2J0Z MT DTT DMS2J0Z MA Inhibitor DMS2J0Z RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health Human Services. 2019 DMS2J0Z RU https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/211810s000lbl.pdf DMS2J0Z DI DMS2J0Z DMS2J0Z DN Pexidartinib DMS2J0Z MI TT7MRDV DMS2J0Z MN Macrophage colony-stimulating factor 1 receptor (CSF1R) DMS2J0Z MT DTT DMS2J0Z MA Inhibitor DMS2J0Z RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health Human Services. 2019 DMS2J0Z RU https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/211810s000lbl.pdf DMS2J0Z DI DMS2J0Z DMS2J0Z DN Pexidartinib DMS2J0Z MI TTX41N9 DMS2J0Z MN Tyrosine-protein kinase Kit (KIT) DMS2J0Z MT DTT DMS2J0Z MA Inhibitor DMS2J0Z RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health Human Services. 2019 DMS2J0Z RU https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/211810s000lbl.pdf DMSB068 DI DMSB068 DMSB068 DN PF-04449913 DMSB068 MI DES5XRU DMSB068 MN Cytochrome P450 2C8 (CYP2C8) DMSB068 MT DME DMSB068 MA Metabolism DMSB068 RN Metabolism, excretion and pharmacokinetics of [14C]glasdegib (PF-04449913) in healthy volunteers following oral administration. Xenobiotica. 2017 Dec;47(12):1064-1076. DMSB068 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=27866461 DMSB068 DI DMSB068 DMSB068 DN PF-04449913 DMSB068 MI TT4LXBC DMSB068 MN Hedgehog signaling pathway (HS pathway) DMSB068 MT DTT DMSB068 MA Inhibitor DMSB068 RN 2018 FDA drug approvals.Nat Rev Drug Discov. 2019 Feb;18(2):85-89. DMSB068 RU https://pubmed.ncbi.nlm.nih.gov/30710142 DMSB068 DI DMSB068 DMSB068 DN PF-04449913 DMSB068 MI TTCJG29 DMSB068 MN Serine/threonine-protein kinase mTOR (mTOR) DMSB068 MT DTT DMSB068 MA Inhibitor DMSB068 RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMSB068 RU http://phrma-docs.phrma.org/files/dmfile/MID_Neurological-Disorders-Drug-List_2018.pdf DMSB068 DI DMSB068 DMSB068 DN PF-04449913 DMSB068 MI TT8J1S3 DMSB068 MN Smoothened homolog (SMO) DMSB068 MT DTT DMSB068 MA Modulator DMSB068 RN Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41. DMSB068 RU https://www.ncbi.nlm.nih.gov/pubmed/15950434 DMSB068 DI DMSB068 DMSB068 DN PF-04449913 DMSB068 MI DE85D2P DMSB068 MN UDP-glucuronosyltransferase 1A9 (UGT1A9) DMSB068 MT DME DMSB068 MA Metabolism DMSB068 RN Metabolism, excretion and pharmacokinetics of [14C]glasdegib (PF-04449913) in healthy volunteers following oral administration. Xenobiotica. 2017 Dec;47(12):1064-1076. DMSB068 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=27866461 DM79VXT DI DM79VXT DM79VXT DN PF-04971729 DM79VXT MI TTLWPVF DM79VXT MN Sodium/glucose cotransporter 2 (SGLT2) DM79VXT MT DTT DM79VXT MA Modulator DM79VXT RN Dose-ranging efficacy and safety study of ertugliflozin, a sodium-glucose co-transporter 2 inhibitor, in patients with type 2 diabetes on a background of metformin.Diabetes Obes Metab.2015 Jun;17(6):591-8. DM79VXT RU https://www.ncbi.nlm.nih.gov/pubmed/25754396 DM79VXT DI DM79VXT DM79VXT DN PF-04971729 DM79VXT MI DE85D2P DM79VXT MN UDP-glucuronosyltransferase 1A9 (UGT1A9) DM79VXT MT DME DM79VXT MA Metabolism DM79VXT RN The effect of renal impairment on the pharmacokinetics and pharmacodynamics of ertugliflozin in subjects with type 2 diabetes mellitus. J Clin Pharmacol. 2017 Nov;57(11):1432-1443. DM79VXT RU https://www.ncbi.nlm.nih.gov/pubmed/?term=28703316 DM79VXT DI DM79VXT DM79VXT DN PF-04971729 DM79VXT MI DEB3CV1 DM79VXT MN UDP-glucuronosyltransferase 2B7 (UGT2B7) DM79VXT MT DME DM79VXT MA Metabolism DM79VXT RN The effect of renal impairment on the pharmacokinetics and pharmacodynamics of ertugliflozin in subjects with type 2 diabetes mellitus. J Clin Pharmacol. 2017 Nov;57(11):1432-1443. DM79VXT RU https://www.ncbi.nlm.nih.gov/pubmed/?term=28703316 DMOHS9P DI DMOHS9P DMOHS9P DN Phenacemide DMOHS9P MI TTRK8B9 DMOHS9P MN Sodium channel unspecific (NaC) DMOHS9P MT DTT DMOHS9P MA Blocker DMOHS9P RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMOHS9P RU https://pubmed.ncbi.nlm.nih.gov/17139284 DM6TS1N DI DM6TS1N DM6TS1N DN Phendimetrazine DM6TS1N MI TTBRKXS DM6TS1N MN Adrenergic receptor alpha-1B (ADRA1B) DM6TS1N MT DTT DM6TS1N MA Antagonist DM6TS1N RN Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. DM6TS1N RU https://pubmed.ncbi.nlm.nih.gov/17016423 DMHIDUE DI DMHIDUE DMHIDUE DN Phenelzine DMHIDUE MI DE4LYSA DMHIDUE MN Cytochrome P450 3A4 (CYP3A4) DMHIDUE MT DME DMHIDUE MA Metabolism DMHIDUE RN An evaluation of potential mechanism-based inactivation of human drug metabolizing cytochromes P450 by monoamine oxidase inhibitors, including isoniazid. Br J Clin Pharmacol. 2006 May;61(5):570-84. DMHIDUE RU https://www.ncbi.nlm.nih.gov/pubmed/?term=16669850 DMHIDUE DI DMHIDUE DMHIDUE DN Phenelzine DMHIDUE MI DEIBDNY DMHIDUE MN Cytochrome P450 3A5 (CYP3A5) DMHIDUE MT DME DMHIDUE MA Metabolism DMHIDUE RN An evaluation of potential mechanism-based inactivation of human drug metabolizing cytochromes P450 by monoamine oxidase inhibitors, including isoniazid. Br J Clin Pharmacol. 2006 May;61(5):570-84. DMHIDUE RU https://www.ncbi.nlm.nih.gov/pubmed/?term=16669850 DMHIDUE DI DMHIDUE DMHIDUE DN Phenelzine DMHIDUE MI DEGTFWK DMHIDUE MN Mephenytoin 4-hydroxylase (CYP2C19) DMHIDUE MT DME DMHIDUE MA Metabolism DMHIDUE RN An evaluation of potential mechanism-based inactivation of human drug metabolizing cytochromes P450 by monoamine oxidase inhibitors, including isoniazid. Br J Clin Pharmacol. 2006 May;61(5):570-84. DMHIDUE RU https://www.ncbi.nlm.nih.gov/pubmed/?term=16669850 DMHIDUE DI DMHIDUE DMHIDUE DN Phenelzine DMHIDUE MI TT32XQJ DMHIDUE MN Monoamine oxidase (MAO) DMHIDUE MT DTT DMHIDUE MA Inhibitor DMHIDUE RN Novel monoamine oxidase inhibitors: a patent review (2012 - 2014).Expert Opin Ther Pat. 2015 Jan;25(1):91-110. DMHIDUE RU https://www.ncbi.nlm.nih.gov/pubmed/25399762 DMHIDUE DI DMHIDUE DMHIDUE DN Phenelzine DMHIDUE MI TTGP7BY DMHIDUE MN Monoamine oxidase type B (MAO-B) DMHIDUE MT DTT DMHIDUE MA Inhibitor DMHIDUE RN Limitation of adipose tissue enlargement in rats chronically treated with semicarbazide-sensitive amine oxidase and monoamine oxidase inhibitors. Pharmacol Res. 2008 Jun;57(6):426-34. DMHIDUE RU https://pubmed.ncbi.nlm.nih.gov/18539478 DMDTC7R DI DMDTC7R DMDTC7R DN Phenindamine DMDTC7R MI TTTIBOJ DMDTC7R MN Histamine H1 receptor (H1R) DMDTC7R MT DTT DMDTC7R MA Antagonist DMDTC7R RN The histamine H1-receptor antagonist binding site. 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DMCH7RU RU https://pubmed.ncbi.nlm.nih.gov/11526976 DMXYTN9 DI DMXYTN9 DMXYTN9 DN Phenmetrazine DMXYTN9 MI TTVBI8W DMXYTN9 MN Dopamine transporter (DAT) DMXYTN9 MT DTT DMXYTN9 MA Inhibitor DMXYTN9 RN Interaction of the anorectic medication, phendimetrazine, and its metabolites with monoamine transporters in rat brain. Eur J Pharmacol. 2002 Jun 28;447(1):51-7. DMXYTN9 RU https://pubmed.ncbi.nlm.nih.gov/12106802 DMXYTN9 DI DMXYTN9 DMXYTN9 DN Phenmetrazine DMXYTN9 MI TTAWNKZ DMXYTN9 MN Norepinephrine transporter (NET) DMXYTN9 MT DTT DMXYTN9 MA Inhibitor DMXYTN9 RN Interaction of the anorectic medication, phendimetrazine, and its metabolites with monoamine transporters in rat brain. Eur J Pharmacol. 2002 Jun 28;447(1):51-7. DMXYTN9 RU https://pubmed.ncbi.nlm.nih.gov/12106802 DMXZOCG DI DMXZOCG DMXZOCG DN Phenobarbital DMXZOCG MI DEPKLMQ DMXZOCG MN Cytochrome P450 2B6 (CYP2B6) DMXZOCG MT DME DMXZOCG MA Metabolism DMXZOCG RN Regulation of CYP2B6 in primary human hepatocytes by prototypical inducers. Drug Metab Dispos. 2004 Mar;32(3):348-58. DMXZOCG RU https://www.ncbi.nlm.nih.gov/pubmed/?term=14977870 DMXZOCG DI DMXZOCG DMXZOCG DN Phenobarbital DMXZOCG MI DEZMWRE DMXZOCG MN Cytochrome P450 2C18 (CYP2C18) DMXZOCG MT DME DMXZOCG MA Metabolism DMXZOCG RN Induction of CYP2C genes in human hepatocytes in primary culture. Drug Metab Dispos. 2001 Mar;29(3):242-51. DMXZOCG RU https://www.ncbi.nlm.nih.gov/pubmed/?term=11181490 DMXZOCG DI DMXZOCG DMXZOCG DN Phenobarbital DMXZOCG MI DES5XRU DMXZOCG MN Cytochrome P450 2C8 (CYP2C8) DMXZOCG MT DME DMXZOCG MA Metabolism DMXZOCG RN Colchicine down-regulates cytochrome P450 2B6, 2C8, 2C9, and 3A4 in human hepatocytes by affecting their glucocorticoid receptor-mediated regulation. Mol Pharmacol. 2003 Jul;64(1):160-9. DMXZOCG RU https://www.ncbi.nlm.nih.gov/pubmed/?term=12815172 DMXZOCG DI DMXZOCG DMXZOCG DN Phenobarbital DMXZOCG MI DE5IED8 DMXZOCG MN Cytochrome P450 2C9 (CYP2C9) DMXZOCG MT DME DMXZOCG MA Metabolism DMXZOCG RN Induction of human CYP2C9 by rifampicin, hyperforin, and phenobarbital is mediated by the pregnane X receptor. J Pharmacol Exp Ther. 2004 Feb;308(2):495-501. DMXZOCG RU https://www.ncbi.nlm.nih.gov/pubmed/?term=14600250 DMXZOCG DI DMXZOCG DMXZOCG DN Phenobarbital DMXZOCG MI DEVDYN7 DMXZOCG MN Cytochrome P450 2E1 (CYP2E1) DMXZOCG MT DME DMXZOCG MA Metabolism DMXZOCG RN Phenobarbital induces monkey brain CYP2E1 protein but not hepatic CYP2E1, in vitro or in vivo chlorzoxazone metabolism. Eur J Pharmacol. 2006 Dec 15;552(1-3):151-8. DMXZOCG RU https://www.ncbi.nlm.nih.gov/pubmed/?term=17049344 DMXZOCG DI DMXZOCG DMXZOCG DN Phenobarbital DMXZOCG MI DE4LYSA DMXZOCG MN Cytochrome P450 3A4 (CYP3A4) DMXZOCG MT DME DMXZOCG MA Metabolism DMXZOCG RN Clinically important drug interactions potentially involving mechanism-based inhibition of cytochrome P450 3A4 and the role of therapeutic drug monitoring. Ther Drug Monit. 2007 Dec;29(6):687-710. DMXZOCG RU https://www.ncbi.nlm.nih.gov/pubmed/?term=18043468 DMXZOCG DI DMXZOCG DMXZOCG DN Phenobarbital DMXZOCG MI DEIBDNY DMXZOCG MN Cytochrome P450 3A5 (CYP3A5) DMXZOCG MT DME DMXZOCG MA Metabolism DMXZOCG RN Induction and regulation of xenobiotic-metabolizing cytochrome P450s in the human A549 lung adenocarcinoma cell line. Am J Respir Cell Mol Biol. 2000 Mar;22(3):360-6. DMXZOCG RU https://www.ncbi.nlm.nih.gov/pubmed/?term=10696073 DMXZOCG DI DMXZOCG DMXZOCG DN Phenobarbital DMXZOCG MI DERD86B DMXZOCG MN Cytochrome P450 3A7 (CYP3A7) DMXZOCG MT DME DMXZOCG MA Metabolism DMXZOCG RN Regulation of human liver cytochromes P-450 in family 3A in primary and continuous culture of human hepatocytes. Hepatology. 1993 Nov;18(5):1254-62. DMXZOCG RU https://www.ncbi.nlm.nih.gov/pubmed/?term=8225233 DMXZOCG DI DMXZOCG DMXZOCG DN Phenobarbital DMXZOCG MI TTNJYV2 DMXZOCG MN Gamma-aminobutyric acid receptor (GAR) DMXZOCG MT DTT DMXZOCG MA Antagonist DMXZOCG RN DrugBank: a knowledgebase for drugs, drug actions and drug targets. Nucleic Acids Res. 2008 Jan;36(Database issue):D901-6. DMXZOCG RU https://pubmed.ncbi.nlm.nih.gov/18048412 DMXZOCG DI DMXZOCG DMXZOCG DN Phenobarbital DMXZOCG MI DEGTFWK DMXZOCG MN Mephenytoin 4-hydroxylase (CYP2C19) DMXZOCG MT DME DMXZOCG MA Metabolism DMXZOCG RN Effects of prototypical microsomal enzyme inducers on cytochrome P450 expression in cultured human hepatocytes. Drug Metab Dispos. 2003 Apr;31(4):421-31. DMXZOCG RU https://www.ncbi.nlm.nih.gov/pubmed/?term=12642468 DMXZOCG DI DMXZOCG DMXZOCG DN Phenobarbital DMXZOCG MI DTFI42L DMXZOCG MN Multidrug resistance-associated protein 2 (ABCC2) DMXZOCG MT DTP DMXZOCG MA Substrate DMXZOCG RN Regulation of multidrug resistance-associated protein 2 (ABCC2) by the nuclear receptors pregnane X receptor, farnesoid X-activated receptor, and constitutive androstane receptor. J Biol Chem. 2002 Jan 25;277(4):2908-15. DMXZOCG RU http://www.ncbi.nlm.nih.gov/pubmed/11706036 DMXZOCG DI DMXZOCG DMXZOCG DN Phenobarbital DMXZOCG MI DTUGYRD DMXZOCG MN P-glycoprotein 1 (ABCB1) DMXZOCG MT DTP DMXZOCG MA Substrate DMXZOCG RN The transport of antiepileptic drugs by P-glycoprotein. Adv Drug Deliv Rev. 2012 Jul;64(10):930-42. DMXZOCG RU https://doi.org/10.1016/j.addr.2011.12.003 DM8KSQH DI DM8KSQH DM8KSQH DN Phenoxybenzamine DM8KSQH MI TTEX248 DM8KSQH MN Dopamine D2 receptor (D2R) DM8KSQH MT DTT DM8KSQH MA Antagonist DM8KSQH RN Catecholamine-secreting neuroblastoma in a 4-month-old infant: perioperative management. J Clin Anesth. 2009 Feb;21(1):54-6. DM8KSQH RU https://pubmed.ncbi.nlm.nih.gov/19232942 DM8KSQH DI DM8KSQH DM8KSQH DN Phenoxybenzamine DM8KSQH MI DTT79CX DM8KSQH MN Organic cation transporter 1 (SLC22A1) DM8KSQH MT DTP DM8KSQH MA Substrate DM8KSQH RN Implications of genetic polymorphisms in drug transporters for pharmacotherapy. Cancer Lett. 2006 Mar 8;234(1):4-33. DM8KSQH RU https://doi.org/10.1016/j.canlet.2005.06.051 DMDO279 DI DMDO279 DMDO279 DN Phenprocoumon DMDO279 MI DES5XRU DMDO279 MN Cytochrome P450 2C8 (CYP2C8) DMDO279 MT DME DMDO279 MA Metabolism DMDO279 RN Identification of cytochromes P450 2C9 and 3A4 as the major catalysts of phenprocoumon hydroxylation in vitro. Eur J Clin Pharmacol. 2004 May;60(3):173-82. DMDO279 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=15054565 DMDO279 DI DMDO279 DMDO279 DN Phenprocoumon DMDO279 MI DE5IED8 DMDO279 MN Cytochrome P450 2C9 (CYP2C9) DMDO279 MT DME DMDO279 MA Metabolism DMDO279 RN Genetic polymorphisms of cytochrome P450 2C9 causing reduced phenprocoumon (S)-7-hydroxylation in vitro and in vivo. Xenobiotica. 2004 Sep;34(9):847-59. DMDO279 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=15742978 DMDO279 DI DMDO279 DMDO279 DN Phenprocoumon DMDO279 MI DE4LYSA DMDO279 MN Cytochrome P450 3A4 (CYP3A4) DMDO279 MT DME DMDO279 MA Metabolism DMDO279 RN Identification of cytochromes P450 2C9 and 3A4 as the major catalysts of phenprocoumon hydroxylation in vitro. Eur J Clin Pharmacol. 2004 May;60(3):173-82. DMDO279 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=15054565 DMDO279 DI DMDO279 DMDO279 DN Phenprocoumon DMDO279 MI DTUGYRD DMDO279 MN P-glycoprotein 1 (ABCB1) DMDO279 MT DTP DMDO279 MA Substrate DMDO279 RN Role of P-glycoprotein in the uptake/efflux transport of oral vitamin K antagonists and rivaroxaban through the Caco-2 cell model. Basic Clin Pharmacol Toxicol. 2013 Oct;113(4):259-65. DMDO279 RU http://www.ncbi.nlm.nih.gov/pubmed/23663291 DMDO279 DI DMDO279 DMDO279 DN Phenprocoumon DMDO279 MI TTEUC8H DMDO279 MN Vitamin K epoxide reductase complex 1 (VKORC1) DMDO279 MT DTT DMDO279 MA Inhibitor DMDO279 RN [Oral anticoagulation and pharmacogenetics: importance in the clinical setting]. Rev Med Suisse. 2007 Sep 12;3(124):2030, 2033-4, 2036. DMDO279 RU https://pubmed.ncbi.nlm.nih.gov/17955831 DMG60XN DI DMG60XN DMG60XN DN Phentermine DMG60XN MI DE4LYSA DMG60XN MN Cytochrome P450 3A4 (CYP3A4) DMG60XN MT DME DMG60XN MA Metabolism DMG60XN RN FDA Label of Qsymia. The 2020 official website of the U.S. Food and Drug Administration. DMG60XN RU https://www.accessdata.fda.gov/drugsatfda_docs/label/2012/022580s000lbl.pdf DMG60XN DI DMG60XN DMG60XN DN Phentermine DMG60XN MI TTAWNKZ DMG60XN MN Norepinephrine transporter (NET) DMG60XN MT DTT DMG60XN MA Inhibitor DMG60XN RN Novel anti-obesity drugs. Expert Opin Investig Drugs. 2000 Jun;9(6):1317-26. DMG60XN RU https://pubmed.ncbi.nlm.nih.gov/11060745 DMXYJOB DI DMXYJOB DMXYJOB DN Phentolamine DMXYJOB MI TTEX248 DMXYJOB MN Dopamine D2 receptor (D2R) DMXYJOB MT DTT DMXYJOB MA Antagonist DMXYJOB RN Nesfatin-1 exerts cardiovascular actions in brain: possible interaction with the central melanocortin system. Am J Physiol Regul Integr Comp Physiol. 2009 Aug;297(2):R330-6. DMXYJOB RU https://pubmed.ncbi.nlm.nih.gov/19474390 DMQ95GE DI DMQ95GE DMQ95GE DN Phenylacetic acid DMQ95GE MI DT39AOM DMQ95GE MN Monocarboxylate transporter 3 (SLC16A8) DMQ95GE MT DTP DMQ95GE MA Substrate DMQ95GE RN Immunohistochemical and functional characterization of peptide, organic cation, neutral and basic amino acid, and monocarboxylate drug transporters in human ocular tissues. Drug Metab Dispos. 2013 Feb;41(2):466-74. DMQ95GE RU http://www.ncbi.nlm.nih.gov/pubmed/23169611 DMAYL0T DI DMAYL0T DMAYL0T DN Phenylbutazone DMAYL0T MI DE5IED8 DMAYL0T MN Cytochrome P450 2C9 (CYP2C9) DMAYL0T MT DME DMAYL0T MA Metabolism DMAYL0T RN Metabolism of sulfinpyrazone sulfide and sulfinpyrazone by human liver microsomes and cDNA-expressed cytochrome P450s. Drug Metab Dispos. 2001 May;29(5):701-11. DMAYL0T RU https://www.ncbi.nlm.nih.gov/pubmed/?term=11302937 DMAYL0T DI DMAYL0T DMAYL0T DN Phenylbutazone DMAYL0T MI TTVKILB DMAYL0T MN Prostaglandin G/H synthase 2 (COX-2) DMAYL0T MT DTT DMAYL0T MA Inhibitor DMAYL0T RN COX-1 and COX-2 inhibition in horse blood by phenylbutazone, flunixin, carprofen and meloxicam: an in vitro analysis. Pharmacol Res. 2005 Oct;52(4):302-6. DMAYL0T RU https://pubmed.ncbi.nlm.nih.gov/15939622 DMAYL0T DI DMAYL0T DMAYL0T DN Phenylbutazone DMAYL0T MI DEYGVN4 DMAYL0T MN UDP-glucuronosyltransferase 1A1 (UGT1A1) DMAYL0T MT DME DMAYL0T MA Metabolism DMAYL0T RN Identification of human UDP-glucuronosyltransferase isoform(s) responsible for the C-glucuronidation of phenylbutazone. Arch Biochem Biophys. 2006 Oct 1;454(1):72-9. DMAYL0T RU https://www.ncbi.nlm.nih.gov/pubmed/?term=16949544 DMZHUO5 DI DMZHUO5 DMZHUO5 DN Phenylephrine DMZHUO5 MI TTEX248 DMZHUO5 MN Dopamine D2 receptor (D2R) DMZHUO5 MT DTT DMZHUO5 MA Agonist DMZHUO5 RN MMP-2 induced vein relaxation via inhibition of [Ca2+]e-dependent mechanisms of venous smooth muscle contraction. Role of RGD peptides. J Surg Res. 2010 Apr;159(2):755-64. DMZHUO5 RU https://pubmed.ncbi.nlm.nih.gov/19482300 DMKAEQW DI DMKAEQW DMKAEQW DN Phenyltoloxamine DMKAEQW MI TTZFYLI DMKAEQW MN Dopamine D1 receptor (D1R) DMKAEQW MT DTT DMKAEQW MA Inhibitor DMKAEQW RN Dopamine/serotonin receptor ligands. 9. Oxygen-containing midsized heterocyclic ring systems and nonrigidized analogues. A step toward dopamine D5 ... J Med Chem. 2004 Aug 12;47(17):4155-8. DMKAEQW RU https://pubmed.ncbi.nlm.nih.gov/15293986 DMKAEQW DI DMKAEQW DMKAEQW DN Phenyltoloxamine DMKAEQW MI TTEX248 DMKAEQW MN Dopamine D2 receptor (D2R) DMKAEQW MT DTT DMKAEQW MA Inhibitor DMKAEQW RN Dopamine/serotonin receptor ligands. 9. Oxygen-containing midsized heterocyclic ring systems and nonrigidized analogues. A step toward dopamine D5 ... J Med Chem. 2004 Aug 12;47(17):4155-8. DMKAEQW RU https://pubmed.ncbi.nlm.nih.gov/15293986 DMKAEQW DI DMKAEQW DMKAEQW DN Phenyltoloxamine DMKAEQW MI TTE0A2F DMKAEQW MN Dopamine D4 receptor (D4R) DMKAEQW MT DTT DMKAEQW MA Inhibitor DMKAEQW RN Dopamine/serotonin receptor ligands. 9. Oxygen-containing midsized heterocyclic ring systems and nonrigidized analogues. A step toward dopamine D5 ... J Med Chem. 2004 Aug 12;47(17):4155-8. DMKAEQW RU https://pubmed.ncbi.nlm.nih.gov/15293986 DMKAEQW DI DMKAEQW DMKAEQW DN Phenyltoloxamine DMKAEQW MI TTS2PH3 DMKAEQW MN Dopamine D5 receptor (D5R) DMKAEQW MT DTT DMKAEQW MA Inhibitor DMKAEQW RN Dopamine/serotonin receptor ligands. 9. Oxygen-containing midsized heterocyclic ring systems and nonrigidized analogues. A step toward dopamine D5 ... J Med Chem. 2004 Aug 12;47(17):4155-8. DMKAEQW RU https://pubmed.ncbi.nlm.nih.gov/15293986 DMNOKBV DI DMNOKBV DMNOKBV DN Phenytoin DMNOKBV MI DEPKLMQ DMNOKBV MN Cytochrome P450 2B6 (CYP2B6) DMNOKBV MT DME DMNOKBV MA Metabolism DMNOKBV RN PharmGKB summary: phenytoin pathway. Pharmacogenet Genomics. 2012 Jun;22(6):466-70. DMNOKBV RU https://www.ncbi.nlm.nih.gov/pubmed/?term=22569204 DMNOKBV DI DMNOKBV DMNOKBV DN Phenytoin DMNOKBV MI DEZMWRE DMNOKBV MN Cytochrome P450 2C18 (CYP2C18) DMNOKBV MT DME DMNOKBV MA Metabolism DMNOKBV RN Summary of information on human CYP enzymes: human P450 metabolism data. Drug Metab Rev. 2002 Feb-May;34(1-2):83-448. DMNOKBV RU https://www.ncbi.nlm.nih.gov/pubmed/?term=11996015 DMNOKBV DI DMNOKBV DMNOKBV DN Phenytoin DMNOKBV MI DES5XRU DMNOKBV MN Cytochrome P450 2C8 (CYP2C8) DMNOKBV MT DME DMNOKBV MA Metabolism DMNOKBV RN Summary of information on human CYP enzymes: human P450 metabolism data. Drug Metab Rev. 2002 Feb-May;34(1-2):83-448. DMNOKBV RU https://www.ncbi.nlm.nih.gov/pubmed/?term=11996015 DMNOKBV DI DMNOKBV DMNOKBV DN Phenytoin DMNOKBV MI DE5IED8 DMNOKBV MN Cytochrome P450 2C9 (CYP2C9) DMNOKBV MT DME DMNOKBV MA Metabolism DMNOKBV RN Antiepileptic drug interactions - principles and clinical implications. Curr Neuropharmacol. 2010 Sep;8(3):254-67. DMNOKBV RU https://www.ncbi.nlm.nih.gov/pubmed/?term=21358975 DMNOKBV DI DMNOKBV DMNOKBV DN Phenytoin DMNOKBV MI DE4LYSA DMNOKBV MN Cytochrome P450 3A4 (CYP3A4) DMNOKBV MT DME DMNOKBV MA Metabolism DMNOKBV RN Coadministration of lopinavir/ritonavir and phenytoin results in two-way drug interaction through cytochrome P-450 induction. J Acquir Immune Defic Syndr. 2004 Aug 15;36(5):1034-40. DMNOKBV RU https://www.ncbi.nlm.nih.gov/pubmed/?term=15247556 DMNOKBV DI DMNOKBV DMNOKBV DN Phenytoin DMNOKBV MI DEIBDNY DMNOKBV MN Cytochrome P450 3A5 (CYP3A5) DMNOKBV MT DME DMNOKBV MA Metabolism DMNOKBV RN PharmGKB summary: phenytoin pathway. Pharmacogenet Genomics. 2012 Jun;22(6):466-70. DMNOKBV RU https://www.ncbi.nlm.nih.gov/pubmed/?term=22569204 DMNOKBV DI DMNOKBV DMNOKBV DN Phenytoin DMNOKBV MI DERD86B DMNOKBV MN Cytochrome P450 3A7 (CYP3A7) DMNOKBV MT DME DMNOKBV MA Metabolism DMNOKBV RN PharmGKB summary: phenytoin pathway. Pharmacogenet Genomics. 2012 Jun;22(6):466-70. DMNOKBV RU https://www.ncbi.nlm.nih.gov/pubmed/?term=22569204 DMNOKBV DI DMNOKBV DMNOKBV DN Phenytoin DMNOKBV MI DE4ZHS1 DMNOKBV MN Glutathione S-transferase alpha-1 (GSTA1) DMNOKBV MT DME DMNOKBV MA Metabolism DMNOKBV RN Comparison of basal glutathione S-transferase activities and of the influence of phenobarbital, butylated hydroxy-anisole or 5,5'-diphenylhydantoin on enzyme activity in male rodents. Comp Biochem Physiol C. 1987;88(1):91-3. DMNOKBV RU https://www.ncbi.nlm.nih.gov/pubmed/?term=2890493 DMNOKBV DI DMNOKBV DMNOKBV DN Phenytoin DMNOKBV MI DEGTFWK DMNOKBV MN Mephenytoin 4-hydroxylase (CYP2C19) DMNOKBV MT DME DMNOKBV MA Metabolism DMNOKBV RN Summary of information on human CYP enzymes: human P450 metabolism data. Drug Metab Rev. 2002 Feb-May;34(1-2):83-448. DMNOKBV RU https://www.ncbi.nlm.nih.gov/pubmed/?term=11996015 DMNOKBV DI DMNOKBV DMNOKBV DN Phenytoin DMNOKBV MI DTSYQGK DMNOKBV MN Multidrug resistance-associated protein 1 (ABCC1) DMNOKBV MT DTP DMNOKBV MA Substrate DMNOKBV RN Evaluation of transport of common antiepileptic drugs by human multidrug resistance-associated proteins (MRP1, 2 and 5) that are overexpressed in pharmacoresistant epilepsy. Neuropharmacology. 2010 Jun;58(7):1019-32. DMNOKBV RU http://www.ncbi.nlm.nih.gov/pubmed/20080116 DMNOKBV DI DMNOKBV DMNOKBV DN Phenytoin DMNOKBV MI DTFI42L DMNOKBV MN Multidrug resistance-associated protein 2 (ABCC2) DMNOKBV MT DTP DMNOKBV MA Substrate DMNOKBV RN Upregulation of brain expression of P-glycoprotein in MRP2-deficient TR(-) rats resembles seizure-induced up-regulation of this drug efflux transporter in normal rats. Epilepsia. 2007 Apr;48(4):631-45. DMNOKBV RU http://www.ncbi.nlm.nih.gov/pubmed/17437408 DMNOKBV DI DMNOKBV DMNOKBV DN Phenytoin DMNOKBV MI DTUGYRD DMNOKBV MN P-glycoprotein 1 (ABCB1) DMNOKBV MT DTP DMNOKBV MA Substrate DMNOKBV RN The transport of antiepileptic drugs by P-glycoprotein. Adv Drug Deliv Rev. 2012 Jul;64(10):930-42. DMNOKBV RU https://doi.org/10.1016/j.addr.2011.12.003 DMNOKBV DI DMNOKBV DMNOKBV DN Phenytoin DMNOKBV MI TTRK8B9 DMNOKBV MN Sodium channel unspecific (NaC) DMNOKBV MT DTT DMNOKBV MA Blocker DMNOKBV RN Lacosamide: a new approach to target voltage-gated sodium currents in epileptic disorders. CNS Drugs. 2009;23(7):555-68. DMNOKBV RU https://pubmed.ncbi.nlm.nih.gov/19552484 DMUKMC8 DI DMUKMC8 DMUKMC8 DN Phloroglucinol DMUKMC8 MI DE69WKO DMUKMC8 MN Phloroglucinol reductase (PHGR) DMUKMC8 MT DME DMUKMC8 MA Metabolism DMUKMC8 RN Purification and properties of phloroglucinol reductase from Eubacterium oxidoreducens G-41. J Biol Chem. 1989 Mar 15;264(8):4423-7. DMUKMC8 RU https://pubmed.ncbi.nlm.nih.gov/2925649 DMUXQG7 DI DMUXQG7 DMUXQG7 DN Phosphate DMUXQG7 MI DTVAEDK DMUXQG7 MN Calcium-binding mitochondrial carrier protein SCaMC-1 (SLC25A24) DMUXQG7 MT DTP DMUXQG7 MA Substrate DMUXQG7 RN De Novo Mutations in SLC25A24 Cause a Disorder Characterized by Early Aging, Bone Dysplasia, Characteristic Face, and Early Demise. Am J Hum Genet. 2017 Nov 2;101(5):844-855. DMUXQG7 RU http://www.ncbi.nlm.nih.gov/pubmed/29100094 DMUXQG7 DI DMUXQG7 DMUXQG7 DN Phosphate DMUXQG7 MI DTN7X5J DMUXQG7 MN Calcium-binding mitochondrial carrier protein SCaMC-2 (SLC25A25) DMUXQG7 MT DTP DMUXQG7 MA Substrate DMUXQG7 RN Ketogenic diet induces expression of the muscle circadian gene Slc25a25 via neural pathway that might be involved in muscle thermogenesis. Sci Rep. 2017 Jun 6;7(1):2885. DMUXQG7 RU http://www.ncbi.nlm.nih.gov/pubmed/28588221 DMUXQG7 DI DMUXQG7 DMUXQG7 DN Phosphate DMUXQG7 MI DTLQ0EZ DMUXQG7 MN Calcium-binding mitochondrial carrier protein SCaMC-3 (SLC25A23) DMUXQG7 MT DTP DMUXQG7 MA Substrate DMUXQG7 RN Cellular expression and alternative splicing of SLC25A23, a member of the mitochondrial Ca2+-dependent solute carrier gene family. Gene. 2005 Jan 31;345(2):173-82. DMUXQG7 RU http://www.ncbi.nlm.nih.gov/pubmed/15716113 DMUXQG7 DI DMUXQG7 DMUXQG7 DN Phosphate DMUXQG7 MI DE9P5K7 DMUXQG7 MN GDP-D-glucose phosphorylase 1 (GDPGP1) DMUXQG7 MT DME DMUXQG7 MA Metabolism DMUXQG7 RN A novel GDP-D-glucose phosphorylase involved in quality control of the nucleoside diphosphate sugar pool in Caenorhabditis elegans and mammals. J Biol Chem. 2011 Jun 17;286(24):21511-23. DMUXQG7 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=21507950 DMUXQG7 DI DMUXQG7 DMUXQG7 DN Phosphate DMUXQG7 MI DTH9SQJ DMUXQG7 MN Glycerol-3-phosphate permease (SLC37A1) DMUXQG7 MT DTP DMUXQG7 MA Substrate DMUXQG7 RN SLC37A1 and SLC37A2 are phosphate-linked, glucose-6-phosphate antiporters. PLoS One. 2011;6(9):e23157. DMUXQG7 RU http://www.ncbi.nlm.nih.gov/pubmed/21949678 DMUXQG7 DI DMUXQG7 DMUXQG7 DN Phosphate DMUXQG7 MI DTJYKDQ DMUXQG7 MN Mitochondrial dicarboxylate carrier (SLC25A10) DMUXQG7 MT DTP DMUXQG7 MA Substrate DMUXQG7 RN SLC25A10 biallelic mutations in intractable epileptic encephalopathy with complex I deficiency. Hum Mol Genet. 2018 Feb 1;27(3):499-504. DMUXQG7 RU http://www.ncbi.nlm.nih.gov/pubmed/29211846 DMUXQG7 DI DMUXQG7 DMUXQG7 DN Phosphate DMUXQG7 MI DTCRIWV DMUXQG7 MN Phosphate carrier protein (SLC25A3) DMUXQG7 MT DTP DMUXQG7 MA Substrate DMUXQG7 RN The mammalian phosphate carrier SLC25A3 is a mitochondrial copper transporter required for cytochrome c oxidase biogenesis. J Biol Chem. 2018 Feb 9;293(6):1887-1896. DMUXQG7 RU http://www.ncbi.nlm.nih.gov/pubmed/29237729 DMUXQG7 DI DMUXQG7 DMUXQG7 DN Phosphate DMUXQG7 MI DTHE530 DMUXQG7 MN Probable small intestine urate exporter (SLC17A4) DMUXQG7 MT DTP DMUXQG7 MA Substrate DMUXQG7 RN A Na+-phosphate cotransporter homologue (SLC17A4 protein) is an intestinal organic anion exporter. Am J Physiol Cell Physiol. 2012 Jun 1;302(11):C1652-60. DMUXQG7 RU http://www.ncbi.nlm.nih.gov/pubmed/22460716 DMUXQG7 DI DMUXQG7 DMUXQG7 DN Phosphate DMUXQG7 MI DT8ARWJ DMUXQG7 MN Sodium-dependent phosphate transport protein 1 (SLC17A1) DMUXQG7 MT DTP DMUXQG7 MA Substrate DMUXQG7 RN Type 1 sodium-dependent phosphate transporter (SLC17A1 Protein) is a Cl(-)-dependent urate exporter. J Biol Chem. 2010 Aug 20;285(34):26107-13. DMUXQG7 RU http://www.ncbi.nlm.nih.gov/pubmed/20566650 DMUXQG7 DI DMUXQG7 DMUXQG7 DN Phosphate DMUXQG7 MI DTFOJL7 DMUXQG7 MN Sodium-dependent phosphate transport protein 4 (SLC17A3) DMUXQG7 MT DTP DMUXQG7 MA Substrate DMUXQG7 RN Human sodium phosphate transporter 4 (hNPT4/SLC17A3) as a common renal secretory pathway for drugs and urate. J Biol Chem. 2010 Nov 5;285(45):35123-32. DMUXQG7 RU http://www.ncbi.nlm.nih.gov/pubmed/20810651 DMUXQG7 DI DMUXQG7 DMUXQG7 DN Phosphate DMUXQG7 MI DTMULXV DMUXQG7 MN Sodium-dependent phosphate transporter 1 (SLC20A1) DMUXQG7 MT DTP DMUXQG7 MA Substrate DMUXQG7 RN Phosphate transporters and their function. Annu Rev Physiol. 2013;75:535-50. DMUXQG7 RU http://www.ncbi.nlm.nih.gov/pubmed/23398154 DMUXQG7 DI DMUXQG7 DMUXQG7 DN Phosphate DMUXQG7 MI DTFD4VB DMUXQG7 MN Sodium-dependent phosphate transporter 2 (SLC20A2) DMUXQG7 MT DTP DMUXQG7 MA Substrate DMUXQG7 RN Phosphate transporters and their function. Annu Rev Physiol. 2013;75:535-50. DMUXQG7 RU http://www.ncbi.nlm.nih.gov/pubmed/23398154 DMUXQG7 DI DMUXQG7 DMUXQG7 DN Phosphate DMUXQG7 MI DTNK0FR DMUXQG7 MN Vesicular glutamate transporter 1 (SLC17A7) DMUXQG7 MT DTP DMUXQG7 MA Substrate DMUXQG7 RN SLC17: a functionally diverse family of organic anion transporters. Mol Aspects Med. 2013 Apr-Jun;34(2-3):350-9. DMUXQG7 RU http://www.ncbi.nlm.nih.gov/pubmed/23506876 DMUXQG7 DI DMUXQG7 DMUXQG7 DN Phosphate DMUXQG7 MI DT5LHCR DMUXQG7 MN Vesicular glutamate transporter 2 (SLC17A6) DMUXQG7 MT DTP DMUXQG7 MA Substrate DMUXQG7 RN Type 1 sodium-dependent phosphate transporter (SLC17A1 Protein) is a Cl(-)-dependent urate exporter. J Biol Chem. 2010 Aug 20;285(34):26107-13. DMUXQG7 RU http://www.ncbi.nlm.nih.gov/pubmed/20566650 DM8HDOL DI DM8HDOL DM8HDOL DN Phytonadione DM8HDOL MI TT76OLR DM8HDOL MN Vitamin K-dependent gamma-carboxylase (GGCX) DM8HDOL MT DTT DM8HDOL MA Cofactor DM8HDOL RN Quinone oxidoreductases and vitamin K metabolism. Vitam Horm. 2008;78:85-101. DM8HDOL RU https://pubmed.ncbi.nlm.nih.gov/18374191 DM27BL1 DI DM27BL1 DM27BL1 DN Pibrentasvir DM27BL1 MI DTUGYRD DM27BL1 MN P-glycoprotein 1 (ABCB1) DM27BL1 MT DTP DM27BL1 MA Substrate DM27BL1 RN Tarascon Pocket Pharmacopoeia 2018 Classic Shirt-Pocket Edition. DM27BL1 RU https://books.google.com/books?id=0gBRDwAAQBAJ&pg=PP37&lpg=PP37&dq=Methylergonovine+transporter+uptake+efflex&source=bl&ots=cUTe_ppsmZ&sig=ACfU3U3E_YqrDg0CNEuj8K-7lci47HAnrg&hl=zh-CN&sa=X&ved=2ahUKEwjnj-Dk7d7iAhUsK6YKHd5DBDkQ6AEwEnoECAgQAQ#v=onepage&q&f=false DMIBNG2 DI DMIBNG2 DMIBNG2 DN Picrotoxin DMIBNG2 MI TT1MPAY DMIBNG2 MN GABA(A) receptor alpha-1 (GABRA1) DMIBNG2 MT DTT DMIBNG2 MA Antagonist DMIBNG2 RN DrugBank: a knowledgebase for drugs, drug actions and drug targets. Nucleic Acids Res. 2008 Jan;36(Database issue):D901-6. DMIBNG2 RU https://pubmed.ncbi.nlm.nih.gov/18048412 DMV9ADG DI DMV9ADG DMV9ADG DN Pilocarpine DMV9ADG MI DEJVYAZ DMV9ADG MN Cytochrome P450 2A6 (CYP2A6) DMV9ADG MT DME DMV9ADG MA Metabolism DMV9ADG RN Structural comparison of cytochromes P450 2A6, 2A13, and 2E1 with pilocarpine. FEBS J. 2012 May;279(9):1621-31. DMV9ADG RU https://www.ncbi.nlm.nih.gov/pubmed/?term=22051186 DMV9ADG DI DMV9ADG DMV9ADG DN Pilocarpine DMV9ADG MI DE4LYSA DMV9ADG MN Cytochrome P450 3A4 (CYP3A4) DMV9ADG MT DME DMV9ADG MA Metabolism DMV9ADG RN The inhibition of CYP enzymes in mouse and human liver by pilocarpine. Br J Pharmacol. 1995 Feb;114(4):832-6. DMV9ADG RU https://www.ncbi.nlm.nih.gov/pubmed/?term=7773543 DMV9ADG DI DMV9ADG DMV9ADG DN Pilocarpine DMV9ADG MI TTH18TF DMV9ADG MN Muscarinic acetylcholine receptor M5 (CHRM5) DMV9ADG MT DTT DMV9ADG MA Agonist DMV9ADG RN Retinoic acid prevents virus-induced airway hyperreactivity and M2 receptor dysfunction via anti-inflammatory and antiviral effects. Am J Physiol Lung Cell Mol Physiol. 2009 Aug;297(2):L340-6. DMV9ADG RU https://pubmed.ncbi.nlm.nih.gov/19465517 DMZ65K8 DI DMZ65K8 DMZ65K8 DN Pilsicainide DMZ65K8 MI TTRK8B9 DMZ65K8 MN Sodium channel unspecific (NaC) DMZ65K8 MT DTT DMZ65K8 MA Modulator DMZ65K8 RN A sodium channel blocker, pilsicainide, produces atrial post-repolarization refractoriness through the reduction of sodium channel availability. Tohoku J Exp Med. 2011;225(1):35-42. DMZ65K8 RU https://pubmed.ncbi.nlm.nih.gov/21869589 DMR7IVC DI DMR7IVC DMR7IVC DN Pimavanserin DMR7IVC MI TTJQOD7 DMR7IVC MN 5-HT 2A receptor (HTR2A) DMR7IVC MT DTT DMR7IVC MA Modulator DMR7IVC RN Pimavanserin, a selective serotonin (5-HT)2A-inverse agonist, enhances the efficacy and safety of risperidone, 2mg/day, but does not enhance efficacy of haloperidol, 2mg/day: comparison with reference dose risperidone, 6mg/day.Schizophr Res.2012 Nov;141(2-3):144-52. DMR7IVC RU https://www.ncbi.nlm.nih.gov/pubmed/22954754 DMZLGRB DI DMZLGRB DMZLGRB DN Pimecrolimus DMZLGRB MI TTA4LDE DMZLGRB MN Calcineurin (PPP3CA) DMZLGRB MT DTT DMZLGRB MA Inhibitor DMZLGRB RN Treatment of chronic blepharokeratoconjunctivitis with local calcineurin inhibitors. Ophthalmologe. 2009 Jul;106(7):635-8. DMZLGRB RU https://pubmed.ncbi.nlm.nih.gov/19499228 DMZLGRB DI DMZLGRB DMZLGRB DN Pimecrolimus DMZLGRB MI DE4LYSA DMZLGRB MN Cytochrome P450 3A4 (CYP3A4) DMZLGRB MT DME DMZLGRB MA Metabolism DMZLGRB RN Pimecrolimus: absorption, distribution, metabolism, and excretion in healthy volunteers after a single oral dose and supplementary investigations in vitro. Drug Metab Dispos. 2006 May;34(5):765-74. DMZLGRB RU https://www.ncbi.nlm.nih.gov/pubmed/?term=16467136 DMW83TP DI DMW83TP DMW83TP DN Pimozide DMW83TP MI DEJGDUW DMW83TP MN Cytochrome P450 1A2 (CYP1A2) DMW83TP MT DME DMW83TP MA Metabolism DMW83TP RN Identification and characterization of human cytochrome P450 isoforms interacting with pimozide. J Pharmacol Exp Ther. 1998 May;285(2):428-37. DMW83TP RU https://www.ncbi.nlm.nih.gov/pubmed/?term=9580580 DMW83TP DI DMW83TP DMW83TP DN Pimozide DMW83TP MI DECB0K3 DMW83TP MN Cytochrome P450 2D6 (CYP2D6) DMW83TP MT DME DMW83TP MA Metabolism DMW83TP RN The influence of the CYP3A4*22 polymorphism and CYP2D6 polymorphisms on serum concentrations of aripiprazole, haloperidol, pimozide, and risperidone in psychiatric patients. J Clin Psychopharmacol. 2015 Jun;35(3):228-36. DMW83TP RU https://www.ncbi.nlm.nih.gov/pubmed/?term=25868121 DMW83TP DI DMW83TP DMW83TP DN Pimozide DMW83TP MI DE4LYSA DMW83TP MN Cytochrome P450 3A4 (CYP3A4) DMW83TP MT DME DMW83TP MA Metabolism DMW83TP RN Identification and characterization of human cytochrome P450 isoforms interacting with pimozide. J Pharmacol Exp Ther. 1998 May;285(2):428-37. DMW83TP RU https://www.ncbi.nlm.nih.gov/pubmed/?term=9580580 DMW83TP DI DMW83TP DMW83TP DN Pimozide DMW83TP MI DEIBDNY DMW83TP MN Cytochrome P450 3A5 (CYP3A5) DMW83TP MT DME DMW83TP MA Metabolism DMW83TP RN Drug Interactions Flockhart Table DMW83TP RU https://drug-interactions.medicine.iu.edu/Main-Table.aspx DMW83TP DI DMW83TP DMW83TP DN Pimozide DMW83TP MI DERD86B DMW83TP MN Cytochrome P450 3A7 (CYP3A7) DMW83TP MT DME DMW83TP MA Metabolism DMW83TP RN Drug Interactions Flockhart Table DMW83TP RU https://drug-interactions.medicine.iu.edu/Main-Table.aspx DMW83TP DI DMW83TP DMW83TP DN Pimozide DMW83TP MI TTEX248 DMW83TP MN Dopamine D2 receptor (D2R) DMW83TP MT DTT DMW83TP MA Antagonist DMW83TP RN [The benzamides tiapride, sulpiride, and amisulpride in treatment for Tourette's syndrome]. Nervenarzt. 2007 Mar;78(3):264, 266-8, 270-1. DMW83TP RU https://pubmed.ncbi.nlm.nih.gov/16924461 DMW83TP DI DMW83TP DMW83TP DN Pimozide DMW83TP MI DTUGYRD DMW83TP MN P-glycoprotein 1 (ABCB1) DMW83TP MT DTP DMW83TP MA Substrate DMW83TP RN Human intestinal transporter database: QSAR modeling and virtual profiling of drug uptake, efflux and interactions. Pharm Res. 2013 Apr;30(4):996-1007. DMW83TP RU https://doi.org/10.1007/s11095-012-0935-x DMRADYL DI DMRADYL DMRADYL DN Pinacidil DMRADYL MI DE4LYSA DMRADYL MN Cytochrome P450 3A4 (CYP3A4) DMRADYL MT DME DMRADYL MA Metabolism DMRADYL RN Cytochrome P450 3A4-mediated oxidative conversion of a cyano to an amide group in the metabolism of pinacidil. Biochemistry. 2002 Feb 26;41(8):2712-8. DMRADYL RU https://www.ncbi.nlm.nih.gov/pubmed/?term=11851418 DMRADYL DI DMRADYL DMRADYL DN Pinacidil DMRADYL MI TT1VOHK DMRADYL MN Potassium channel unspecific (KC) DMRADYL MT DTT DMRADYL MA Modulator DMRADYL RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. DMRADYL RU https://www.fda.gov/ DMD2NV7 DI DMD2NV7 DMD2NV7 DN Pindolol DMD2NV7 MI TTR6W5O DMD2NV7 MN Adrenergic receptor beta-1 (ADRB1) DMD2NV7 MT DTT DMD2NV7 MA Antagonist DMD2NV7 RN Are we misunderstanding beta-blockers. Int J Cardiol. 2007 Aug 9;120(1):10-27. DMD2NV7 RU https://pubmed.ncbi.nlm.nih.gov/17433471 DMKJ485 DI DMKJ485 DMKJ485 DN Pioglitazone DMKJ485 MI DES5XRU DMKJ485 MN Cytochrome P450 2C8 (CYP2C8) DMKJ485 MT DME DMKJ485 MA Metabolism DMKJ485 RN The role of human CYP2C8 and CYP2C9 variants in pioglitazone metabolism in vitro. Basic Clin Pharmacol Toxicol. 2009 Dec;105(6):374-9. DMKJ485 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=19614891 DMKJ485 DI DMKJ485 DMKJ485 DN Pioglitazone DMKJ485 MI DE5IED8 DMKJ485 MN Cytochrome P450 2C9 (CYP2C9) DMKJ485 MT DME DMKJ485 MA Metabolism DMKJ485 RN Current clinical evidence on pioglitazone pharmacogenomics. Front Pharmacol. 2013 Nov 26;4:147. DMKJ485 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=24324437 DMKJ485 DI DMKJ485 DMKJ485 DN Pioglitazone DMKJ485 MI DE4LYSA DMKJ485 MN Cytochrome P450 3A4 (CYP3A4) DMKJ485 MT DME DMKJ485 MA Metabolism DMKJ485 RN Pioglitazone is metabolised by CYP2C8 and CYP3A4 in vitro: potential for interactions with CYP2C8 inhibitors. Basic Clin Pharmacol Toxicol. 2006 Jul;99(1):44-51. DMKJ485 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=16867170 DMKJ485 DI DMKJ485 DMKJ485 DN Pioglitazone DMKJ485 MI TTZMAO3 DMKJ485 MN Peroxisome proliferator-activated receptor gamma (PPAR-gamma) DMKJ485 MT DTT DMKJ485 MA Agonist DMKJ485 RN Functional PPAR-gamma receptor is a novel therapeutic target for ACTH-secreting pituitary adenomas. Nat Med. 2002 Nov;8(11):1281-7. DMKJ485 RU https://pubmed.ncbi.nlm.nih.gov/12379847 DMKJ485 DI DMKJ485 DMKJ485 DN Pioglitazone DMKJ485 MI DE073H6 DMKJ485 MN Prostaglandin G/H synthase 1 (COX-1) DMKJ485 MT DME DMKJ485 MA Metabolism DMKJ485 RN Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. DMKJ485 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=19515014 DM5F84A DI DM5F84A DM5F84A DN Pipecuronium DM5F84A MI TTF4E0J DM5F84A MN Neuronal acetylcholine receptor alpha-2 (CHRNA2) DM5F84A MT DTT DM5F84A MA Antagonist DM5F84A RN Synergy between pairs of competitive antagonists at adult human muscle acetylcholine receptors. Anesth Analg. 2008 Aug;107(2):525-33. DM5F84A RU https://pubmed.ncbi.nlm.nih.gov/18633030 DMGQU0Y DI DMGQU0Y DMGQU0Y DN Piperacetazine DMGQU0Y MI TTEX248 DMGQU0Y MN Dopamine D2 receptor (D2R) DMGQU0Y MT DTT DMGQU0Y MA Modulator DMGQU0Y RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. DMGQU0Y RU https://www.fda.gov/ DMTBKF3 DI DMTBKF3 DMTBKF3 DN Piperacillin DMTBKF3 MI TTJP4SM DMTBKF3 MN Bacterial Penicillin binding protein (Bact PBP) DMTBKF3 MT DTT DMTBKF3 MA Binder DMTBKF3 RN In vitro antienterococcal activity explains associations between exposures to antimicrobial agents and risk of colonization by multiresistant enter... J Infect Dis. 2004 Dec 15;190(12):2162-6. DMTBKF3 RU https://pubmed.ncbi.nlm.nih.gov/15551215 DMTBKF3 DI DMTBKF3 DMTBKF3 DN Piperacillin DMTBKF3 MI DET9I1W DMTBKF3 MN Beta-lactamase (blaB) DMTBKF3 MT DME DMTBKF3 MA Metabolism DMTBKF3 RN Purification and characterization of a new beta-lactamase from Bacteroides uniformis. Antimicrob Agents Chemother. 1995 Jul;39(7):1458-61. DMTBKF3 RU https://pubmed.ncbi.nlm.nih.gov/7492085 DMTBKF3 DI DMTBKF3 DMTBKF3 DN Piperacillin DMTBKF3 MI DEEZ5CV DMTBKF3 MN Beta-lactamase (blaB) DMTBKF3 MT DME DMTBKF3 MA Metabolism DMTBKF3 RN Characterization of piperacillin/tazobactam-resistant klebsiella oxytoca recovered from a nosocomial outbreak. PLoS One. 2015 Nov 5;10(11):e0142366. DMTBKF3 RU https://pubmed.ncbi.nlm.nih.gov/26539828 DMTBKF3 DI DMTBKF3 DMTBKF3 DN Piperacillin DMTBKF3 MI DEYIEO5 DMTBKF3 MN Beta-lactamase (blaB) DMTBKF3 MT DME DMTBKF3 MA Metabolism DMTBKF3 RN Determination of the antibiotic resistance rates of Serratia marcescens isolates obtained from various clinical specimens. Niger J Clin Pract. 2019 Jan;22(1):125-130. DMTBKF3 RU https://pubmed.ncbi.nlm.nih.gov/30666031 DMTBKF3 DI DMTBKF3 DMTBKF3 DN Piperacillin DMTBKF3 MI DT9G7XN DMTBKF3 MN Peptide transporter 1 (SLC15A1) DMTBKF3 MT DTP DMTBKF3 MA Substrate DMTBKF3 RN Three-dimensional quantitative structure-activity relationship analyses of beta-lactam antibiotics and tripeptides as substrates of the mammalian H+/peptide cotransporter PEPT1. J Med Chem. 2005 Jun 30;48(13):4410-9. DMTBKF3 RU http://www.ncbi.nlm.nih.gov/pubmed/15974593 DMT70RC DI DMT70RC DMT70RC DN Piperaquine DMT70RC MI DE5IED8 DMT70RC MN Cytochrome P450 2C9 (CYP2C9) DMT70RC MT DME DMT70RC MA Metabolism DMT70RC RN Eurartesim - European Medicines Agency DMT70RC RU http://www.ema.europa.eu/docs/en_GB/document_library/EPAR_-_Public_assessment_report/human/001199/WC500118116.pdf DMT70RC DI DMT70RC DMT70RC DN Piperaquine DMT70RC MI DEGTFWK DMT70RC MN Mephenytoin 4-hydroxylase (CYP2C19) DMT70RC MT DME DMT70RC MA Metabolism DMT70RC RN Open-label crossover study of primaquine and dihydroartemisinin-piperaquine pharmacokinetics in healthy adult thai subjects. Antimicrob Agents Chemother. 2014 Dec;58(12):7340-6. DMT70RC RU https://www.ncbi.nlm.nih.gov/pubmed/?term=25267661 DMT70RC DI DMT70RC DMT70RC DN Piperaquine DMT70RC MI TTZVSJ2 DMT70RC MN Sarcoplasmic/endoplasmic reticulum calcium ATPase (ATP2A) DMT70RC MT DTT DMT70RC MA Inhibitor DMT70RC RN The fight against drug-resistant malaria: novel plasmodial targets and antimalarial drugs. Curr Med Chem. 2008;15(2):161-71. DMT70RC RU https://pubmed.ncbi.nlm.nih.gov/18220771 DMTY9LU DI DMTY9LU DMTY9LU DN Piperazine DMTY9LU MI DECB0K3 DMTY9LU MN Cytochrome P450 2D6 (CYP2D6) DMTY9LU MT DME DMTY9LU MA Metabolism DMTY9LU RN Chemistry, pharmacology, toxicology, and hepatic metabolism of designer drugs of the amphetamine (ecstasy), piperazine, and pyrrolidinophenone types: a synopsis. Ther Drug Monit. 2004 Apr;26(2):127-31. DMTY9LU RU https://www.ncbi.nlm.nih.gov/pubmed/?term=15228152 DMTY9LU DI DMTY9LU DMTY9LU DN Piperazine DMTY9LU MI TTNJYV2 DMTY9LU MN Gamma-aminobutyric acid receptor (GAR) DMTY9LU MT DTT DMTY9LU MA Antagonist DMTY9LU RN Cyclooctadepsipeptides--an anthelmintically active class of compounds exhibiting a novel mode of action. Int J Antimicrob Agents. 2003 Sep;22(3):318-31. DMTY9LU RU https://pubmed.ncbi.nlm.nih.gov/13678839 DMNL0E6 DI DMNL0E6 DMNL0E6 DN Pipobroman DMNL0E6 MI TTUTN1I DMNL0E6 MN Human Deoxyribonucleic acid (hDNA) DMNL0E6 MT DTT DMNL0E6 MA Binder DMNL0E6 RN Effects of piposulfan (Ancyte) on protein and DNA synthesis in Ehrlich ascites carcinoma. Life Sci II. 1971 Jun 8;10(11):605-12. DMNL0E6 RU https://pubmed.ncbi.nlm.nih.gov/5556760 DMC68DF DI DMC68DF DMC68DF DN Pipotiazine DMC68DF MI DECB0K3 DMC68DF MN Cytochrome P450 2D6 (CYP2D6) DMC68DF MT DME DMC68DF MA Metabolism DMC68DF RN Polymorphism of human cytochrome P450 2D6 and its clinical significance: part II. Clin Pharmacokinet. 2009;48(12):761-804. DMC68DF RU https://www.ncbi.nlm.nih.gov/pubmed/?term=19902987 DMC68DF DI DMC68DF DMC68DF DN Pipotiazine DMC68DF MI DE4LYSA DMC68DF MN Cytochrome P450 3A4 (CYP3A4) DMC68DF MT DME DMC68DF MA Metabolism DMC68DF RN Main contribution of the cytochrome P450 isoenzyme 1A2 (CYP1A2) to N-demethylation and 5-sulfoxidation of the phenothiazine neuroleptic chlorpromazine in human liver--A comparison with other phenothiazines. Biochem Pharmacol. 2010 Oct 15;80(8):1252-9. DMC68DF RU https://www.ncbi.nlm.nih.gov/pubmed/?term=20615392 DMC68DF DI DMC68DF DMC68DF DN Pipotiazine DMC68DF MI DEGTFWK DMC68DF MN Mephenytoin 4-hydroxylase (CYP2C19) DMC68DF MT DME DMC68DF MA Metabolism DMC68DF RN Main contribution of the cytochrome P450 isoenzyme 1A2 (CYP1A2) to N-demethylation and 5-sulfoxidation of the phenothiazine neuroleptic chlorpromazine in human liver--A comparison with other phenothiazines. Biochem Pharmacol. 2010 Oct 15;80(8):1252-9. DMC68DF RU https://www.ncbi.nlm.nih.gov/pubmed/?term=20615392 DMGTW1I DI DMGTW1I DMGTW1I DN Pirarubicin DMGTW1I MI DTI7UX6 DMGTW1I MN Breast cancer resistance protein (ABCG2) DMGTW1I MT DTP DMGTW1I MA Substrate DMGTW1I RN Role of BCRP as a biomarker for predicting resistance to 5-fluorouracil in breast cancer. Cancer Chemother Pharmacol. 2009 May;63(6):1103-10. DMGTW1I RU http://www.ncbi.nlm.nih.gov/pubmed/18820913 DMGTW1I DI DMGTW1I DMGTW1I DN Pirarubicin DMGTW1I MI TTUTN1I DMGTW1I MN Human Deoxyribonucleic acid (hDNA) DMGTW1I MT DTT DMGTW1I MA Modulator DMGTW1I RN Natural products as sources of new drugs over the last 25 years. J Nat Prod. 2007 Mar;70(3):461-77. DMGTW1I RU https://pubmed.ncbi.nlm.nih.gov/17309302 DMGTW1I DI DMGTW1I DMGTW1I DN Pirarubicin DMGTW1I MI DTUGYRD DMGTW1I MN P-glycoprotein 1 (ABCB1) DMGTW1I MT DTP DMGTW1I MA Substrate DMGTW1I RN Human intestinal transporter database: QSAR modeling and virtual profiling of drug uptake, efflux and interactions. Pharm Res. 2013 Apr;30(4):996-1007. DMGTW1I RU https://doi.org/10.1007/s11095-012-0935-x DMI5678 DI DMI5678 DMI5678 DN Pirbuterol DMI5678 MI TT2CJVK DMI5678 MN Adrenergic receptor beta-2 (ADRB2) DMI5678 MT DTT DMI5678 MA Agonist DMI5678 RN Inhaled beta agonists. Respir Care. 2007 Jul;52(7):820-32. DMI5678 RU https://pubmed.ncbi.nlm.nih.gov/17594727 DMP6M1N DI DMP6M1N DMP6M1N DN Pirenzepine DMP6M1N MI TTZ9SOR DMP6M1N MN Muscarinic acetylcholine receptor M1 (CHRM1) DMP6M1N MT DTT DMP6M1N MA Antagonist DMP6M1N RN Negative crosstalk between M1 and M2 muscarinic autoreceptors involves endogenous adenosine activating A1 receptors at the rat motor endplate. Neurosci Lett. 2009 Aug 14;459(3):127-31. DMP6M1N RU https://pubmed.ncbi.nlm.nih.gov/19427366 DMP6M1N DI DMP6M1N DMP6M1N DN Pirenzepine DMP6M1N MI DTUGYRD DMP6M1N MN P-glycoprotein 1 (ABCB1) DMP6M1N MT DTP DMP6M1N MA Substrate DMP6M1N RN Passive permeability and P-glycoprotein-mediated efflux differentiate central nervous system (CNS) and non-CNS marketed drugs. J Pharmacol Exp Ther. 2002 Dec;303(3):1029-37. DMP6M1N RU http://www.ncbi.nlm.nih.gov/pubmed/12438524 DM6VZFQ DI DM6VZFQ DM6VZFQ DN Pirfenidone DM6VZFQ MI DEJGDUW DM6VZFQ MN Cytochrome P450 1A2 (CYP1A2) DM6VZFQ MT DME DM6VZFQ MA Metabolism DM6VZFQ RN Risk of clinically relevant pharmacokinetic-based drug-drug interactions with drugs approved by the U.S. Food and Drug Administration between 2013 and 2016. Drug Metab Dispos. 2018 Jun;46(6):835-845. DM6VZFQ RU https://www.ncbi.nlm.nih.gov/pubmed/?term=29572333 DM6VZFQ DI DM6VZFQ DM6VZFQ DN Pirfenidone DM6VZFQ MI TTR9XHZ DM6VZFQ MN Transforming growth factor beta 1 (TGFB1) DM6VZFQ MT DTT DM6VZFQ MA Modulator DM6VZFQ RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. DM6VZFQ RU https://www.fda.gov/ DMBCYF5 DI DMBCYF5 DMBCYF5 DN Pirmenol DMBCYF5 MI TTRK8B9 DMBCYF5 MN Sodium channel unspecific (NaC) DMBCYF5 MT DTT DMBCYF5 MA Modulator DMBCYF5 RN Pirmenol, a new antiarrhythmic drug with potassium- and sodium-channel blocking activity; a voltage-clamp study in rabbit Purkinje fibres. Naunyn Schmiedebergs Arch Pharmacol. 1990 May;341(5):462-71. DMBCYF5 RU https://pubmed.ncbi.nlm.nih.gov/2164163 DMTK234 DI DMTK234 DMTK234 DN Piroxicam DMTK234 MI DES5XRU DMTK234 MN Cytochrome P450 2C8 (CYP2C8) DMTK234 MT DME DMTK234 MA Metabolism DMTK234 RN Efficacy of piroxicam for postoperative pain after lower third molar surgery associated with CYP2C8*3 and CYP2C9 J Pain Res. 2017 Jul 6;10:1581-1589. DMTK234 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=28740425 DMTK234 DI DMTK234 DMTK234 DN Piroxicam DMTK234 MI DE5IED8 DMTK234 MN Cytochrome P450 2C9 (CYP2C9) DMTK234 MT DME DMTK234 MA Metabolism DMTK234 RN Functional characterization of human CYP2C9 allelic variants in COS-7 cells. Front Pharmacol. 2016 Apr 25;7:98. DMTK234 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=27199745 DMTK234 DI DMTK234 DMTK234 DN Piroxicam DMTK234 MI TT8NGED DMTK234 MN Prostaglandin G/H synthase 1 (COX-1) DMTK234 MT DTT DMTK234 MA Modulator DMTK234 RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. DMTK234 RU https://www.fda.gov/ DMMOFHT DI DMMOFHT DMMOFHT DN Pirprofen DMMOFHT MI DEYGVN4 DMMOFHT MN UDP-glucuronosyltransferase 1A1 (UGT1A1) DMMOFHT MT DME DMMOFHT MA Metabolism DMMOFHT RN Glucuronidation of 2-arylpropionic acids pirprofen, flurbiprofen, and ibuprofen by liver microsomes. Drug Metab Dispos. 1990 Sep-Oct;18(5):692-7. DMMOFHT RU https://www.ncbi.nlm.nih.gov/pubmed/?term=1981722 DMJH792 DI DMJH792 DMJH792 DN Pitavastatin DMJH792 MI DTI7UX6 DMJH792 MN Breast cancer resistance protein (ABCG2) DMJH792 MT DTP DMJH792 MA Substrate DMJH792 RN ABCG2: a perspective. Adv Drug Deliv Rev. 2009 Jan 31;61(1):3-13. DMJH792 RU https://doi.org/10.1016/j.addr.2008.11.003 DMJH792 DI DMJH792 DMJH792 DN Pitavastatin DMJH792 MI DTFI42L DMJH792 MN Multidrug resistance-associated protein 2 (ABCC2) DMJH792 MT DTP DMJH792 MA Substrate DMJH792 RN Involvement of BCRP (ABCG2) in the biliary excretion of pitavastatin. Mol Pharmacol. 2005 Sep;68(3):800-7. DMJH792 RU http://www.ncbi.nlm.nih.gov/pubmed/15955871 DMJH792 DI DMJH792 DMJH792 DN Pitavastatin DMJH792 MI DTE2B1D DMJH792 MN Organic anion transporting polypeptide 1A2 (SLCO1A2) DMJH792 MT DTP DMJH792 MA Substrate DMJH792 RN Transporter-mediated influx and efflux mechanisms of pitavastatin, a new inhibitor of HMG-CoA reductase. J Pharm Pharmacol. 2005 Oct;57(10):1305-11. DMJH792 RU http://www.ncbi.nlm.nih.gov/pubmed/16259759 DMJH792 DI DMJH792 DMJH792 DN Pitavastatin DMJH792 MI DT3D8F0 DMJH792 MN Organic anion transporting polypeptide 1B1 (SLCO1B1) DMJH792 MT DTP DMJH792 MA Substrate DMJH792 RN Prediction of the in vivo OATP1B1-mediated drug-drug interaction potential of an investigational drug against a range of statins. Eur J Pharm Sci. 2012 Aug 30;47(1):244-55. DMJH792 RU http://www.ncbi.nlm.nih.gov/pubmed/22538052 DMJH792 DI DMJH792 DMJH792 DN Pitavastatin DMJH792 MI DT9C1TS DMJH792 MN Organic anion transporting polypeptide 1B3 (SLCO1B3) DMJH792 MT DTP DMJH792 MA Substrate DMJH792 RN Impact of OATP transporters on pharmacokinetics. Br J Pharmacol. 2009 Oct;158(3):693-705. DMJH792 RU http://www.ncbi.nlm.nih.gov/pubmed/19785645 DMJH792 DI DMJH792 DMJH792 DN Pitavastatin DMJH792 MI DTPFTEQ DMJH792 MN Organic anion transporting polypeptide 2B1 (SLCO2B1) DMJH792 MT DTP DMJH792 MA Substrate DMJH792 RN Intestinal absorption of HMG-CoA reductase inhibitor pitavastatin mediated by organic anion transporting polypeptide and P-glycoprotein/multidrug resistance 1. Drug Metab Pharmacokinet. 2011;26(2):171-9. DMJH792 RU https://doi.org/10.2133/dmpk.DMPK-10-RG-073 DM1UJO0 DI DM1UJO0 DM1UJO0 DN Pitavastatin calcium DM1UJO0 MI DTI7UX6 DM1UJO0 MN Breast cancer resistance protein (ABCG2) DM1UJO0 MT DTP DM1UJO0 MA Substrate DM1UJO0 RN Involvement of BCRP (ABCG2) in the biliary excretion of pitavastatin. Mol Pharmacol. 2005 Sep;68(3):800-7. DM1UJO0 RU http://www.ncbi.nlm.nih.gov/pubmed/15955871 DM1UJO0 DI DM1UJO0 DM1UJO0 DN Pitavastatin calcium DM1UJO0 MI DES5XRU DM1UJO0 MN Cytochrome P450 2C8 (CYP2C8) DM1UJO0 MT DME DM1UJO0 MA Metabolism DM1UJO0 RN Comparison of the safety, tolerability, and pharmacokinetic profile of a single oral dose of pitavastatin 4 mg in adult subjects with severe renal impairment not on hemodialysis versus healthy adult subjects. J Cardiovasc Pharmacol. 2012 Jul;60(1):42-8. DM1UJO0 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=22472908 DM1UJO0 DI DM1UJO0 DM1UJO0 DN Pitavastatin calcium DM1UJO0 MI DE5IED8 DM1UJO0 MN Cytochrome P450 2C9 (CYP2C9) DM1UJO0 MT DME DM1UJO0 MA Metabolism DM1UJO0 RN Pitavastatin: a review in hypercholesterolemia. Am J Cardiovasc Drugs. 2017 Apr;17(2):157-168. DM1UJO0 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=28130659 DM1UJO0 DI DM1UJO0 DM1UJO0 DN Pitavastatin calcium DM1UJO0 MI TTPADOQ DM1UJO0 MN HMG-CoA reductase (HMGCR) DM1UJO0 MT DTT DM1UJO0 MA Inhibitor DM1UJO0 RN Cholesterol-lowering effect of NK-104, a 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitor, in guinea pig model of hyperlipidemia. Arzneimittelforschung. 2001;51(3):197-203. DM1UJO0 RU https://pubmed.ncbi.nlm.nih.gov/11304935 DM1UJO0 DI DM1UJO0 DM1UJO0 DN Pitavastatin calcium DM1UJO0 MI DTFI42L DM1UJO0 MN Multidrug resistance-associated protein 2 (ABCC2) DM1UJO0 MT DTP DM1UJO0 MA Substrate DM1UJO0 RN Mammalian drug efflux transporters of the ATP binding cassette (ABC) family in multidrug resistance: A review of the past decade. Cancer Lett. 2016 Jan 1;370(1):153-64. DM1UJO0 RU http://www.ncbi.nlm.nih.gov/pubmed/26499806 DM1UJO0 DI DM1UJO0 DM1UJO0 DN Pitavastatin calcium DM1UJO0 MI DTVP67E DM1UJO0 MN Organic anion transporter 3 (SLC22A8) DM1UJO0 MT DTP DM1UJO0 MA Substrate DM1UJO0 RN Transporter-mediated influx and efflux mechanisms of pitavastatin, a new inhibitor of HMG-CoA reductase. J Pharm Pharmacol. 2005 Oct;57(10):1305-11. 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DM1UJO0 RU http://www.ncbi.nlm.nih.gov/pubmed/18408565 DM1UJO0 DI DM1UJO0 DM1UJO0 DN Pitavastatin calcium DM1UJO0 MI DT9C1TS DM1UJO0 MN Organic anion transporting polypeptide 1B3 (SLCO1B3) DM1UJO0 MT DTP DM1UJO0 MA Substrate DM1UJO0 RN Contribution of OATP2 (OATP1B1) and OATP8 (OATP1B3) to the hepatic uptake of pitavastatin in humans. J Pharmacol Exp Ther. 2004 Oct;311(1):139-46. DM1UJO0 RU http://www.ncbi.nlm.nih.gov/pubmed/15159445 DM1UJO0 DI DM1UJO0 DM1UJO0 DN Pitavastatin calcium DM1UJO0 MI DTPFTEQ DM1UJO0 MN Organic anion transporting polypeptide 2B1 (SLCO2B1) DM1UJO0 MT DTP DM1UJO0 MA Substrate DM1UJO0 RN Drug-drug interaction between pitavastatin and various drugs via OATP1B1. Drug Metab Dispos. 2006 Jul;34(7):1229-36. DM1UJO0 RU http://www.ncbi.nlm.nih.gov/pubmed/16595711 DM1UJO0 DI DM1UJO0 DM1UJO0 DN Pitavastatin calcium DM1UJO0 MI DT56EKP DM1UJO0 MN Sodium/taurocholate cotransporting polypeptide (SLC10A1) DM1UJO0 MT DTP DM1UJO0 MA Substrate DM1UJO0 RN Transporter-mediated influx and efflux mechanisms of pitavastatin, a new inhibitor of HMG-CoA reductase. J Pharm Pharmacol. 2005 Oct;57(10):1305-11. DM1UJO0 RU http://www.ncbi.nlm.nih.gov/pubmed/16259759 DM1UJO0 DI DM1UJO0 DM1UJO0 DN Pitavastatin calcium DM1UJO0 MI DEYGVN4 DM1UJO0 MN UDP-glucuronosyltransferase 1A1 (UGT1A1) DM1UJO0 MT DME DM1UJO0 MA Metabolism DM1UJO0 RN Metabolic fate of pitavastatin, a new inhibitor of HMG-CoA reductase: human UDP-glucuronosyltransferase enzymes involved in lactonization. Xenobiotica. 2003 Jan;33(1):27-41. 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U.S. Department of Health Human Services. 2019 DM8RFNJ RU https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/211150s000lbl.pdf DMX8CVY DI DMX8CVY DMX8CVY DN Pivampicillin DMX8CVY MI TTJP4SM DMX8CVY MN Bacterial Penicillin binding protein (Bact PBP) DMX8CVY MT DTT DMX8CVY MA Binder DMX8CVY RN Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. DMX8CVY RU https://pubmed.ncbi.nlm.nih.gov/17016423 DMDU0BV DI DMDU0BV DMDU0BV DN Pivmecillinam DMDU0BV MI TTJP4SM DMDU0BV MN Bacterial Penicillin binding protein (Bact PBP) DMDU0BV MT DTT DMDU0BV MA Binder DMDU0BV RN Association between antimicrobial consumption and resistance in Escherichia coli. Antimicrob Agents Chemother. 2009 Mar;53(3):912-7. DMDU0BV RU https://pubmed.ncbi.nlm.nih.gov/19104012 DMV74ZH DI DMV74ZH DMV74ZH DN Pizotyline DMV74ZH MI TT85JO3 DMV74ZH MN 5-HT receptor (5HTR) DMV74ZH MT DTT DMV74ZH MA Modulator DMV74ZH RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015 DMV74ZH RU https://www.accessdata.fda.gov/scripts/cder/drugsatfda/ DMV74ZH DI DMV74ZH DMV74ZH DN Pizotyline DMV74ZH MI DEI8NGH DMV74ZH MN UDP-glucuronosyltransferase 2B10 (UGT2B10) DMV74ZH MT DME DMV74ZH MA Metabolism DMV74ZH RN Human UDP-glucuronosyltransferase (UGT) 2B10 in drug N-glucuronidation: substrate screening and comparison with UGT1A3 and UGT1A4. Drug Metab Dispos. 2013 Jul;41(7):1389-97. DMV74ZH RU https://www.ncbi.nlm.nih.gov/pubmed/?term=23611809 DMKMBES DI DMKMBES DMKMBES DN Plazomicin DMKMBES MI DE69QHT DMKMBES MN Aminoglycoside acetyltransferase (aac) DMKMBES MT DME DMKMBES MA Metabolism DMKMBES RN Plazomicin retains antibiotic activity against most aminoglycoside modifying enzymes. ACS Infect Dis. 2018 Jun 8;4(6):980-987. 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U.S. Department of Health Human Services. 2019 DMF6Y0L RU https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/761121s000lbl.pdf DMF6Y0L DI DMF6Y0L DMF6Y0L DN Polatuzumab vedotin DMF6Y0L MI DE4LYSA DMF6Y0L MN Cytochrome P450 3A4 (CYP3A4) DMF6Y0L MT DME DMF6Y0L MA Metabolism DMF6Y0L RN FDA label of Polatuzumab vedotin-piiq. The 2020 official website of the U.S. Food and Drug Administration. DMF6Y0L RU https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/761121s000lbl.pdf DMH1KMT DI DMH1KMT DMH1KMT DN Polidocanol DMH1KMT MI TTT6K3S DMH1KMT MN Endothelium of blood vessels (Endothelium) DMH1KMT MT DTT DMH1KMT MA Modulator DMH1KMT RN Drugs@FDA. U.S. Food and Drug Administration. 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DM0PMGJ RU https://www.fda.gov/ DM4I1JP DI DM4I1JP DM4I1JP DN Polyethylene glycol DM4I1JP MI DEIOH6A DM4I1JP MN Alcohol dehydrogenase class-III (ADH5) DM4I1JP MT DME DM4I1JP MA Metabolism DM4I1JP RN PEGylated proteins: evaluation of their safety in the absence of definitive metabolism studies. Drug Metab Dispos. 2007 Jan;35(1):9-16. DM4I1JP RU https://www.ncbi.nlm.nih.gov/pubmed/?term=17020954 DMN0LP8 DI DMN0LP8 DMN0LP8 DN Polymyxin B Sulfate DMN0LP8 MI TT4ILYC DMN0LP8 MN Bacterial Dihydropteroate synthetase (Bact folP) DMN0LP8 MT DTT DMN0LP8 MA Binder DMN0LP8 RN Polymyxin B sulfate and colistin: old antibiotics for emerging multiresistant gram-negative bacteria. Ann Pharmacother. 1999 Sep;33(9):960-7. DMN0LP8 RU https://pubmed.ncbi.nlm.nih.gov/10492501 DMJAOT1 DI DMJAOT1 DMJAOT1 DN Polyoxidonium DMJAOT1 MI TT3J5ZI DMJAOT1 MN Cell mediated immunity response (CMIR) DMJAOT1 MT DTT DMJAOT1 MA Modulator DMJAOT1 RN Effect of polyoxidonium on the phagocytic activity of human peripheral blood leukocytes. Russ J Immunol. 2003 Apr;8(1):53-60. DMJAOT1 RU https://pubmed.ncbi.nlm.nih.gov/12717555 DMCH80F DI DMCH80F DMCH80F DN Polythiazide DMCH80F MI TTP362L DMCH80F MN Solute carrier family 12 member 3 (SLC12A3) DMCH80F MT DTT DMCH80F MA Blocker DMCH80F RN The renal thiazide-sensitive Na-Cl cotransporter as mediator of the aldosterone-escape phenomenon. J Clin Invest. 2001 Jul;108(2):215-22. DMCH80F RU https://pubmed.ncbi.nlm.nih.gov/11457874 DMTGBAX DI DMTGBAX DMTGBAX DN Pomalidomide DMTGBAX MI TTDIBYJ DMTGBAX MN Angiogenesis/myeloma cell growth (AMCG) DMTGBAX MT DTT DMTGBAX MA Modulator DMTGBAX RN Radium 223 dichloride for prostate cancer treatment. 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Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. (ID: DB08910) DMTGBAX RU https://www.drugbank.ca/drugs/DB08910 DMYGJQO DI DMYGJQO DMYGJQO DN Ponatinib DMYGJQO MI DTI7UX6 DMYGJQO MN Breast cancer resistance protein (ABCG2) DMYGJQO MT DTP DMYGJQO MA Substrate DMYGJQO RN DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. (ID: DB08901) DMYGJQO RU https://www.drugbank.ca/drugs/DB08901 DMYGJQO DI DMYGJQO DMYGJQO DN Ponatinib DMYGJQO MI DECB0K3 DMYGJQO MN Cytochrome P450 2D6 (CYP2D6) DMYGJQO MT DME DMYGJQO MA Metabolism DMYGJQO RN Novel pathways of ponatinib disposition catalyzed by CYP1A1 involving generation of potentially toxic metabolites. J Pharmacol Exp Ther. 2017 Oct;363(1):12-19. DMYGJQO RU https://www.ncbi.nlm.nih.gov/pubmed/?term=28882992 DMYGJQO DI DMYGJQO DMYGJQO DN Ponatinib DMYGJQO MI DE4LYSA DMYGJQO MN Cytochrome P450 3A4 (CYP3A4) DMYGJQO MT DME DMYGJQO MA Metabolism DMYGJQO RN Evaluation of the effect of multiple doses of rifampin on the pharmacokinetics and safety of ponatinib in healthy subjects. Clin Pharmacol Drug Dev. 2015 Sep;4(5):354-60. DMYGJQO RU https://www.ncbi.nlm.nih.gov/pubmed/?term=27137144 DMYGJQO DI DMYGJQO DMYGJQO DN Ponatinib DMYGJQO MI DEIBDNY DMYGJQO MN Cytochrome P450 3A5 (CYP3A5) DMYGJQO MT DME DMYGJQO MA Metabolism DMYGJQO RN Potential of ponatinib to treat chronic myeloid leukemia and acute lymphoblastic leukemia. Onco Targets Ther. 2013 Aug 20;6:1111-8. DMYGJQO RU https://www.ncbi.nlm.nih.gov/pubmed/?term=23986642 DMYGJQO DI DMYGJQO DMYGJQO DN Ponatinib DMYGJQO MI TTGJCWZ DMYGJQO MN Fms-like tyrosine kinase 3 (FLT-3) DMYGJQO MT DTT DMYGJQO MA Modulator DMYGJQO RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015 DMYGJQO RU https://www.accessdata.fda.gov/scripts/cder/drugsatfda/ DMYGJQO DI DMYGJQO DMYGJQO DN Ponatinib DMYGJQO MI DTUGYRD DMYGJQO MN P-glycoprotein 1 (ABCB1) DMYGJQO MT DTP DMYGJQO MA Substrate DMYGJQO RN DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. (ID: DB08901) DMYGJQO RU https://www.drugbank.ca/drugs/DB08901 DMYGJQO DI DMYGJQO DMYGJQO DN Ponatinib DMYGJQO MI TT4DXQT DMYGJQO MN Proto-oncogene c-Ret (RET) DMYGJQO MT DTT DMYGJQO MA Modulator DMYGJQO RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015 DMYGJQO RU https://www.accessdata.fda.gov/scripts/cder/drugsatfda/ DMYGJQO DI DMYGJQO DMYGJQO DN Ponatinib DMYGJQO MI TT3PJMV DMYGJQO MN Tyrosine-protein kinase ABL1 (ABL) DMYGJQO MT DTT DMYGJQO MA Modulator DMYGJQO RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015 DMYGJQO RU https://www.accessdata.fda.gov/scripts/cder/drugsatfda/ DMYGJQO DI DMYGJQO DMYGJQO DN Ponatinib DMYGJQO MI TTX41N9 DMYGJQO MN Tyrosine-protein kinase Kit (KIT) DMYGJQO MT DTT DMYGJQO MA Modulator DMYGJQO RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015 DMYGJQO RU https://www.accessdata.fda.gov/scripts/cder/drugsatfda/ DMEAOYJ DI DMEAOYJ DMEAOYJ DN Ponesimod DMEAOYJ MI TT9JZCK DMEAOYJ MN Sphingosine-1-phosphate receptor 1 (S1PR1) DMEAOYJ MT DTT DMEAOYJ MA Agonist DMEAOYJ RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health Human Services. 2021 DMEAOYJ RU https://www.accessdata.fda.gov/drugsatfda_docs/label/2021/213498s000lbl.pdf DM7ZWNY DI DM7ZWNY DM7ZWNY DN Porfimer Sodium DM7ZWNY MI TTH0DUS DM7ZWNY MN Low-density lipoprotein receptor (LDL-R) DM7ZWNY MT DTT DM7ZWNY MA Modulator DM7ZWNY RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. DM7ZWNY RU https://www.fda.gov/ DMUL5EW DI DMUL5EW DMUL5EW DN Posaconazole DMUL5EW MI TTTSOUD DMUL5EW MN Candida Cytochrome P450 51 (Candi ERG11) DMUL5EW MT DTT DMUL5EW MA Inhibitor DMUL5EW RN A new, broad-spectrum azole antifungal: posaconazole--mechanisms of action and resistance, spectrum of activity. Mycoses. 2006;49 Suppl 1:2-6. DMUL5EW RU https://pubmed.ncbi.nlm.nih.gov/16961575 DMUL5EW DI DMUL5EW DMUL5EW DN Posaconazole DMUL5EW MI DE4LYSA DMUL5EW MN Cytochrome P450 3A4 (CYP3A4) DMUL5EW MT DME DMUL5EW MA Metabolism DMUL5EW RN Survey of computed tomography doses and establishment of national diagnostic reference levels in the Republic of Belarus. Radiat Prot Dosimetry. 2010 Apr-May;139(1-3):367-70. DMUL5EW RU https://www.ncbi.nlm.nih.gov/pubmed/?term=20181649 DMUL5EW DI DMUL5EW DMUL5EW DN Posaconazole DMUL5EW MI DTUGYRD DMUL5EW MN P-glycoprotein 1 (ABCB1) DMUL5EW MT DTP DMUL5EW MA Substrate DMUL5EW RN KEGG: new perspectives on genomes, pathways, diseases and drugs. Nucleic Acids Res. 2017 Jan 4;45(D1):D353-D361. (dg:DG01665) DMUL5EW RU https://www.kegg.jp/dbget-bin/www_bget?dg:DG01665 DMUL5EW DI DMUL5EW DMUL5EW DN Posaconazole DMUL5EW MI DEYGVN4 DMUL5EW MN UDP-glucuronosyltransferase 1A1 (UGT1A1) DMUL5EW MT DME DMUL5EW MA Metabolism DMUL5EW RN Identification of human UDP-glucuronosyltransferase enzyme(s) responsible for the glucuronidation of posaconazole (Noxafil). Drug Metab Dispos. 2004 Feb;32(2):267-71. DMUL5EW RU https://www.ncbi.nlm.nih.gov/pubmed/?term=14744950 DMMTAJC DI DMMTAJC DMMTAJC DN Potassium chloride DMMTAJC MI DTHKL3Q DMMTAJC MN Basolateral Na-K-Cl symporter (SLC12A2) DMMTAJC MT DTP DMMTAJC MA Substrate DMMTAJC RN Expression of the sodium potassium chloride cotransporter (NKCC1) and sodium chloride cotransporter (NCC) and their effects on rat lens transparency. Mol Vis. 2010 May 4;16:800-12. DMMTAJC RU http://www.ncbi.nlm.nih.gov/pubmed/20458365 DMMTAJC DI DMMTAJC DMMTAJC DN Potassium chloride DMMTAJC MI DTO1UQY DMMTAJC MN Bumetanide-sensitive sodium-(potassium)-chloride cotransporter 2 (SLC12A1) DMMTAJC MT DTP DMMTAJC MA Substrate DMMTAJC RN Rare mutations in renal sodium and potassium transporter genes exhibit impaired transport function. Curr Opin Nephrol Hypertens. 2014 Jan;23(1):1-8. DMMTAJC RU http://www.ncbi.nlm.nih.gov/pubmed/24253496 DMMTAJC DI DMMTAJC DMMTAJC DN Potassium chloride DMMTAJC MI DTY25IU DMMTAJC MN Electroneutral potassium-chloride cotransporter 1 (SLC12A4) DMMTAJC MT DTP DMMTAJC MA Substrate DMMTAJC RN Human potassium chloride cotransporter 1 (SLC12A4) promoter is regulated by AP-2 and contains a functional downstream promoter element. Blood. 2004 Jun 1;103(11):4302-9. DMMTAJC RU http://www.ncbi.nlm.nih.gov/pubmed/14976052 DMMTAJC DI DMMTAJC DMMTAJC DN Potassium chloride DMMTAJC MI DTD62VB DMMTAJC MN Electroneutral potassium-chloride cotransporter 2 (SLC12A5) DMMTAJC MT DTP DMMTAJC MA Substrate DMMTAJC RN Tyrosine phosphorylation regulates the membrane trafficking of the potassium chloride co-transporter KCC2. Mol Cell Neurosci. 2010 Oct;45(2):173-9. DMMTAJC RU http://www.ncbi.nlm.nih.gov/pubmed/20600929 DMMTAJC DI DMMTAJC DMMTAJC DN Potassium chloride DMMTAJC MI DTMA4FJ DMMTAJC MN Electroneutral potassium-chloride cotransporter 3 (SLC12A6) DMMTAJC MT DTP DMMTAJC MA Substrate DMMTAJC RN Functional analysis of a potassium-chloride co-transporter 3 (SLC12A6) promoter polymorphism leading to an additional DNA methylation site. Neuropsychopharmacology. 2009 Jan;34(2):458-67. DMMTAJC RU http://www.ncbi.nlm.nih.gov/pubmed/18536702 DMMTAJC DI DMMTAJC DMMTAJC DN Potassium chloride DMMTAJC MI DT3HUVD DMMTAJC MN Organic cation/carnitine transporter 2 (SLC22A5) DMMTAJC MT DTP DMMTAJC MA Substrate DMMTAJC RN Mutations affecting GABAergic signaling in seizures and epilepsy. Pflugers Arch. 2010 Jul;460(2):505-23. DMMTAJC RU http://www.ncbi.nlm.nih.gov/pubmed/20352446 DMMTAJC DI DMMTAJC DMMTAJC DN Potassium chloride DMMTAJC MI TTS087L DMMTAJC MN Solute carrier family 12 member 1 (SLC12A1) DMMTAJC MT DTT DMMTAJC MA Modulator DMMTAJC RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. DMMTAJC RU https://www.fda.gov/ DMGLZ26 DI DMGLZ26 DMGLZ26 DN Practolol DMGLZ26 MI TTR6W5O DMGLZ26 MN Adrenergic receptor beta-1 (ADRB1) DMGLZ26 MT DTT DMGLZ26 MA Antagonist DMGLZ26 RN Prostaglandin E2 synthesis elicited by adrenergic stimuli in guinea pig trachea is mediated primarily via activation of beta 2 adrenergic receptors. Prostaglandins. 1992 Nov;44(5):399-412. DMGLZ26 RU https://pubmed.ncbi.nlm.nih.gov/1335153 DMGLZ26 DI DMGLZ26 DMGLZ26 DN Practolol DMGLZ26 MI DECB0K3 DMGLZ26 MN Cytochrome P450 2D6 (CYP2D6) DMGLZ26 MT DME DMGLZ26 MA Metabolism DMGLZ26 RN Application of substrate depletion assay to evaluation of CYP isoforms responsible for stereoselective metabolism of carvedilol. Drug Metab Pharmacokinet. 2016 Dec;31(6):425-432. DMGLZ26 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=27836712 DMAO80I DI DMAO80I DMAO80I DN Pralatrexate DMAO80I MI DTOSN46 DMAO80I MN Folate transporter 1 (SLC19A1) DMAO80I MT DTP DMAO80I MA Substrate DMAO80I RN Antifolates in cancer therapy: structure, activity and mechanisms of drug resistance. Drug Resist Updat. 2012 Aug;15(4):183-210. DMAO80I RU http://www.ncbi.nlm.nih.gov/pubmed/22921318 DMAO80I DI DMAO80I DMAO80I DN Pralatrexate DMAO80I MI DECWT2V DMAO80I MN Folylpolyglutamate synthase (FPGS) DMAO80I MT DME DMAO80I MA Metabolism DMAO80I RN Pralatrexate : evaluation of clinical efficacy and toxicity in T-cell lymphoma. Expert Opin Pharmacother. 2013 Mar;14(4):515-23. DMAO80I RU https://www.ncbi.nlm.nih.gov/pubmed/?term=23409799 DMAO80I DI DMAO80I DMAO80I DN Pralatrexate DMAO80I MI TT9SL3Q DMAO80I MN Polypeptide deformylase (PDF) DMAO80I MT DTT DMAO80I MA Inhibitor DMAO80I RN Hughes B: 2009 FDA drug approvals. Nat Rev Drug Discov. 2010 Feb;9(2):89-92. DMAO80I RU https://pubmed.ncbi.nlm.nih.gov/20118952 DMAO80I DI DMAO80I DMAO80I DN Pralatrexate DMAO80I MI DTDJEMI DMAO80I MN Proton-coupled folate transporter (SLC46A1) DMAO80I MT DTP DMAO80I MA Substrate DMAO80I RN Antifolates in cancer therapy: structure, activity and mechanisms of drug resistance. Drug Resist Updat. 2012 Aug;15(4):183-210. DMAO80I RU http://www.ncbi.nlm.nih.gov/pubmed/22921318 DMGQ0ZI DI DMGQ0ZI DMGQ0ZI DN Pralidoxime chloride DMGQ0ZI MI TT1RS9F DMGQ0ZI MN Acetylcholinesterase (AChE) DMGQ0ZI MT DTT DMGQ0ZI MA Modulator DMGQ0ZI RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. DMGQ0ZI RU https://www.fda.gov/ DMWU0I2 DI DMWU0I2 DMWU0I2 DN Pralsetinib DMWU0I2 MI TT4DXQT DMWU0I2 MN Proto-oncogene c-Ret (RET) DMWU0I2 MT DTT DMWU0I2 MA Inhibitor DMWU0I2 RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health Human Services. 2020 DMWU0I2 RU https://www.accessdata.fda.gov/drugsatfda_docs/label/2020/213721s000lbl.pdf DMNMW9R DI DMNMW9R DMNMW9R DN Pramipexole DMNMW9R MI TTEX248 DMNMW9R MN Dopamine D2 receptor (D2R) DMNMW9R MT DTT DMNMW9R MA Modulator DMNMW9R RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. DMNMW9R RU https://www.fda.gov/ DMNMW9R DI DMNMW9R DMNMW9R DN Pramipexole DMNMW9R MI TT4C8EA DMNMW9R MN Dopamine D3 receptor (D3R) DMNMW9R MT DTT DMNMW9R MA Modulator DMNMW9R RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. DMNMW9R RU https://www.fda.gov/ DMNMW9R DI DMNMW9R DMNMW9R DN Pramipexole DMNMW9R MI DTT79CX DMNMW9R MN Organic cation transporter 1 (SLC22A1) DMNMW9R MT DTP DMNMW9R MA Substrate DMNMW9R RN OCT1 polymorphism is associated with response and survival time in anti-Parkinsonian drug users. Neurogenetics. 2011 Feb;12(1):79-82. DMNMW9R RU http://www.ncbi.nlm.nih.gov/pubmed/20680652 DMNMW9R DI DMNMW9R DMNMW9R DN Pramipexole DMNMW9R MI DT9IDPW DMNMW9R MN Organic cation transporter 2 (SLC22A2) DMNMW9R MT DTP DMNMW9R MA Substrate DMNMW9R RN Uptake of pramipexole by human organic cation transporters. Mol Pharm. 2010 Aug 2;7(4):1342-7. DMNMW9R RU http://www.ncbi.nlm.nih.gov/pubmed/20496886 DM2FHG3 DI DM2FHG3 DM2FHG3 DN Pramiracetam DM2FHG3 MI TTH18TF DM2FHG3 MN Muscarinic acetylcholine receptor M5 (CHRM5) DM2FHG3 MT DTT DM2FHG3 MA Modulator DM2FHG3 RN Some neurochemical properties of pramiracetam (CI-879), a new cognition-enhancing agent. Article first published online: 5 OCT 2004. DM2FHG3 RU http://onlinelibrary.wiley.com/doi/10.1002/ddr.430030503/abstract DM0EZ9Q DI DM0EZ9Q DM0EZ9Q DN Pramlintide DM0EZ9Q MI TTVIMDE DM0EZ9Q MN Glucagon-like peptide 1 receptor (GLP1R) DM0EZ9Q MT DTT DM0EZ9Q MA Agonist DM0EZ9Q RN Emerging drugs for obesity: linking novel biological mechanisms to pharmaceutical pipelines. Expert Opin Emerg Drugs. 2005 Aug;10(3):643-60. DM0EZ9Q RU https://pubmed.ncbi.nlm.nih.gov/16083333 DMYHDCA DI DMYHDCA DMYHDCA DN Pranlukast DMYHDCA MI DE4LYSA DMYHDCA MN Cytochrome P450 3A4 (CYP3A4) DMYHDCA MT DME DMYHDCA MA Metabolism DMYHDCA RN Effect of clarithromycin on the pharmacokinetics of pranlukast in healthy volunteers. Drug Metab Pharmacokinet. 2008;23(6):428-33.; DMYHDCA RU https://www.ncbi.nlm.nih.gov/pubmed/?term=19122337 DMYHDCA DI DMYHDCA DMYHDCA DN Pranlukast DMYHDCA MI TTGKOY9 DMYHDCA MN Leukotriene CysLT1 receptor (CYSLTR1) DMYHDCA MT DTT DMYHDCA MA Antagonist DMYHDCA RN Beneficial effects of leukotriene receptor antagonists in the prevention of cedar pollinosis in a community setting. J Investig Allergol Clin Immunol. 2009;19(3):195-203. DMYHDCA RU https://pubmed.ncbi.nlm.nih.gov/19610262 DM67VKL DI DM67VKL DM67VKL DN Prasterone DM67VKL MI TTS64P2 DM67VKL MN Androgen receptor (AR) DM67VKL MT DTT DM67VKL MA Antagonist DM67VKL RN Dehydroepiandrosterone, glucose-6-phosphate dehydrogenase, and longevity. Ageing Res Rev. 2004 Apr;3(2):171-87. DM67VKL RU https://pubmed.ncbi.nlm.nih.gov/15177053 DM67VKL DI DM67VKL DM67VKL DN Prasterone DM67VKL MI DEQX145 DM67VKL MN Aromatase (CYP19A1) DM67VKL MT DME DM67VKL MA Metabolism DM67VKL RN Urinary and serum octopamine in patients with portal-systemic encephalopathy. Lancet. 1975 Nov 15;2(7942):943-6. DM67VKL RU https://www.ncbi.nlm.nih.gov/pubmed/?term=53430 DM67VKL DI DM67VKL DM67VKL DN Prasterone DM67VKL MI DEN0GVQ DM67VKL MN Beta-HSD adrenal and gonadal type (HSD3B2) DM67VKL MT DME DM67VKL MA Metabolism DM67VKL RN Selective inhibition of human 3beta-hydroxysteroid dehydrogenase type 1 as a potential treatment for breast cancer. J Steroid Biochem Mol Biol. 2011 May;125(1-2):57-65. DM67VKL RU https://www.ncbi.nlm.nih.gov/pubmed/?term=20736065 DM67VKL DI DM67VKL DM67VKL DN Prasterone DM67VKL MI DTI7UX6 DM67VKL MN Breast cancer resistance protein (ABCG2) DM67VKL MT DTP DM67VKL MA Substrate DM67VKL RN Human intestinal transporter database: QSAR modeling and virtual profiling of drug uptake, efflux and interactions. Pharm Res. 2013 Apr;30(4):996-1007. DM67VKL RU https://doi.org/10.1007/s11095-012-0935-x DM67VKL DI DM67VKL DM67VKL DN Prasterone DM67VKL MI DE4LYSA DM67VKL MN Cytochrome P450 3A4 (CYP3A4) DM67VKL MT DME DM67VKL MA Metabolism DM67VKL RN Contribution of human hepatic cytochrome P450 isoforms to regioselective hydroxylation of steroid hormones. Xenobiotica. 1998 Jun;28(6):539-47. DM67VKL RU https://www.ncbi.nlm.nih.gov/pubmed/?term=9667077 DM67VKL DI DM67VKL DM67VKL DN Prasterone DM67VKL MI DERD86B DM67VKL MN Cytochrome P450 3A7 (CYP3A7) DM67VKL MT DME DM67VKL MA Metabolism DM67VKL RN Summary of information on human CYP enzymes: human P450 metabolism data. Drug Metab Rev. 2002 Feb-May;34(1-2):83-448. DM67VKL RU https://www.ncbi.nlm.nih.gov/pubmed/?term=11996015 DM67VKL DI DM67VKL DM67VKL DN Prasterone DM67VKL MI DE36TMY DM67VKL MN Cytochrome P450 7B1 (CYP7B1) DM67VKL MT DME DM67VKL MA Metabolism DM67VKL RN CYP7B1-mediated metabolism of dehydroepiandrosterone and 5alpha-androstane-3beta,17beta-diol--potential role(s) for estrogen signaling. FEBS J. 2008 Apr;275(8):1778-89. DM67VKL RU https://pubmed.ncbi.nlm.nih.gov/18331353 DM67VKL DI DM67VKL DM67VKL DN Prasterone DM67VKL MI DERDQWN DM67VKL MN Dihydrotestosterone oxidoreductase (HSD3B1) DM67VKL MT DME DM67VKL MA Metabolism DM67VKL RN Selective inhibition of human 3beta-hydroxysteroid dehydrogenase type 1 as a potential treatment for breast cancer. J Steroid Biochem Mol Biol. 2011 May;125(1-2):57-65. DM67VKL RU https://www.ncbi.nlm.nih.gov/pubmed/?term=20736065 DM67VKL DI DM67VKL DM67VKL DN Prasterone DM67VKL MI DEZS5YK DM67VKL MN Estradiol 17-beta-dehydrogenase 1 (HSD17B1) DM67VKL MT DME DM67VKL MA Metabolism DM67VKL RN Steroid signalling in the ovarian surface epithelium. Trends Endocrinol Metab. 2005 Sep;16(7):327-33. DM67VKL RU https://www.ncbi.nlm.nih.gov/pubmed/?term=16054388 DM67VKL DI DM67VKL DM67VKL DN Prasterone DM67VKL MI DEBMFZ8 DM67VKL MN Estradiol 17-beta-dehydrogenase 2 (HSD17B2) DM67VKL MT DME DM67VKL MA Metabolism DM67VKL RN Steroid signalling in the ovarian surface epithelium. Trends Endocrinol Metab. 2005 Sep;16(7):327-33. DM67VKL RU https://www.ncbi.nlm.nih.gov/pubmed/?term=16054388 DM67VKL DI DM67VKL DM67VKL DN Prasterone DM67VKL MI TTKN8W0 DM67VKL MN Glucose-6-phosphate dehydrogenase (G6PD) DM67VKL MT DTT DM67VKL MA Inhibitor DM67VKL RN Glucose utilization and activity of glucose-6-phosphate dehydrogenase, isocitrate dehydrogenase and malate dehydrogenase in rat erythrocytes after treatment with tuberculostatic agents. Vopr Med Khim. 1986 Sep-Oct;32(5):32-5. DM67VKL RU https://pubmed.ncbi.nlm.nih.gov/3776114 DM67VKL DI DM67VKL DM67VKL DN Prasterone DM67VKL MI DTCSGPB DM67VKL MN Multidrug resistance-associated protein 4 (ABCC4) DM67VKL MT DTP DM67VKL MA Substrate DM67VKL RN Steroid and bile acid conjugates are substrates of human multidrug-resistance protein (MRP) 4 (ATP-binding cassette C4). Biochem J. 2003 Apr 15;371(Pt 2):361-7. DM67VKL RU http://www.ncbi.nlm.nih.gov/pubmed/12523936 DM67VKL DI DM67VKL DM67VKL DN Prasterone DM67VKL MI DTWN7FC DM67VKL MN Multidrug resistance-associated protein 8 (ABCC11) DM67VKL MT DTP DM67VKL MA Substrate DM67VKL RN Human multidrug resistance protein 8 (MRP8/ABCC11), an apical efflux pump for steroid sulfates, is an axonal protein of the CNS and peripheral nervous system. Neuroscience. 2006;137(4):1247-57. DM67VKL RU http://www.ncbi.nlm.nih.gov/pubmed/16359813 DM67VKL DI DM67VKL DM67VKL DN Prasterone DM67VKL MI DTVP67E DM67VKL MN Organic anion transporter 3 (SLC22A8) DM67VKL MT DTP DM67VKL MA Substrate DM67VKL RN Identification and characterization of human organic anion transporter 3 expressing predominantly in the kidney. Mol Pharmacol. 2001 May;59(5):1277-86. DM67VKL RU http://www.ncbi.nlm.nih.gov/pubmed/11306713 DM67VKL DI DM67VKL DM67VKL DN Prasterone DM67VKL MI DEJHG19 DM67VKL MN Peroxisomal multifunctional enzyme 2 (HSD17B4) DM67VKL MT DME DM67VKL MA Metabolism DM67VKL RN Steroid signalling in the ovarian surface epithelium. Trends Endocrinol Metab. 2005 Sep;16(7):327-33. DM67VKL RU https://www.ncbi.nlm.nih.gov/pubmed/?term=16054388 DM67VKL DI DM67VKL DM67VKL DN Prasterone DM67VKL MI DE0P6LK DM67VKL MN Sulfotransferase 2A1 (SULT2A1) DM67VKL MT DME DM67VKL MA Metabolism DM67VKL RN Sulfation of environmental estrogens by cytosolic human sulfotransferases. Drug Metab Pharmacokinet. 2002;17(3):221-8. DM67VKL RU https://www.ncbi.nlm.nih.gov/pubmed/?term=15618673 DM67VKL DI DM67VKL DM67VKL DN Prasterone DM67VKL MI DEZBN53 DM67VKL MN Sulfotransferase 2B1 (SULT2B1) DM67VKL MT DME DM67VKL MA Metabolism DM67VKL RN Expression and characterization of the human 3 beta-hydroxysteroid sulfotransferases (SULT2B1a and SULT2B1b). J Steroid Biochem Mol Biol. 2001 Jun;77(4-5):261-9. DM67VKL RU https://www.ncbi.nlm.nih.gov/pubmed/?term=11457664 DM7MT6E DI DM7MT6E DM7MT6E DN Prasugrel DM7MT6E MI DEPKLMQ DM7MT6E MN Cytochrome P450 2B6 (CYP2B6) DM7MT6E MT DME DM7MT6E MA Metabolism DM7MT6E RN The evolution of antiplatelet therapy in the treatment of acute coronary syndromes: from aspirin to the present day. Drugs. 2012 Nov 12;72(16):2087-116. DM7MT6E RU https://www.ncbi.nlm.nih.gov/pubmed/?term=23083110 DM7MT6E DI DM7MT6E DM7MT6E DN Prasugrel DM7MT6E MI DE5IED8 DM7MT6E MN Cytochrome P450 2C9 (CYP2C9) DM7MT6E MT DME DM7MT6E MA Metabolism DM7MT6E RN The evolution of antiplatelet therapy in the treatment of acute coronary syndromes: from aspirin to the present day. Drugs. 2012 Nov 12;72(16):2087-116. DM7MT6E RU https://www.ncbi.nlm.nih.gov/pubmed/?term=23083110 DM7MT6E DI DM7MT6E DM7MT6E DN Prasugrel DM7MT6E MI DE4LYSA DM7MT6E MN Cytochrome P450 3A4 (CYP3A4) DM7MT6E MT DME DM7MT6E MA Metabolism DM7MT6E RN The evolution of antiplatelet therapy in the treatment of acute coronary syndromes: from aspirin to the present day. Drugs. 2012 Nov 12;72(16):2087-116. DM7MT6E RU https://www.ncbi.nlm.nih.gov/pubmed/?term=23083110 DM7MT6E DI DM7MT6E DM7MT6E DN Prasugrel DM7MT6E MI DEGTFWK DM7MT6E MN Mephenytoin 4-hydroxylase (CYP2C19) DM7MT6E MT DME DM7MT6E MA Metabolism DM7MT6E RN The evolution of antiplatelet therapy in the treatment of acute coronary syndromes: from aspirin to the present day. Drugs. 2012 Nov 12;72(16):2087-116. DM7MT6E RU https://www.ncbi.nlm.nih.gov/pubmed/?term=23083110 DM7MT6E DI DM7MT6E DM7MT6E DN Prasugrel DM7MT6E MI TTZ1DT0 DM7MT6E MN P2Y purinoceptor 12 (P2RY12) DM7MT6E MT DTT DM7MT6E MA Inhibitor DM7MT6E RN Hughes B: 2009 FDA drug approvals. Nat Rev Drug Discov. 2010 Feb;9(2):89-92. DM7MT6E RU https://pubmed.ncbi.nlm.nih.gov/20118952 DM6A0X7 DI DM6A0X7 DM6A0X7 DN Pravastatin DM6A0X7 MI DTJ0EW4 DM6A0X7 MN Bile salt export pump (ABCB11) DM6A0X7 MT DTP DM6A0X7 MA Substrate DM6A0X7 RN Bile salt export pump (BSEP/ABCB11) can transport a nonbile acid substrate, pravastatin. J Pharmacol Exp Ther. 2005 Aug;314(2):876-82. DM6A0X7 RU http://www.ncbi.nlm.nih.gov/pubmed/15901796 DM6A0X7 DI DM6A0X7 DM6A0X7 DN Pravastatin DM6A0X7 MI DTI7UX6 DM6A0X7 MN Breast cancer resistance protein (ABCG2) DM6A0X7 MT DTP DM6A0X7 MA Substrate DM6A0X7 RN Mammalian drug efflux transporters of the ATP binding cassette (ABC) family in multidrug resistance: A review of the past decade. Cancer Lett. 2016 Jan 1;370(1):153-64. DM6A0X7 RU http://www.ncbi.nlm.nih.gov/pubmed/26499806 DM6A0X7 DI DM6A0X7 DM6A0X7 DN Pravastatin DM6A0X7 MI DE5IED8 DM6A0X7 MN Cytochrome P450 2C9 (CYP2C9) DM6A0X7 MT DME DM6A0X7 MA Metabolism DM6A0X7 RN In vitro comparative inhibition profiles of major human drug metabolising cytochrome P450 isozymes (CYP2C9, CYP2D6 and CYP3A4) by HMG-CoA reductase inhibitors. Eur J Clin Pharmacol. 1996;50(3):209-15. DM6A0X7 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=8737761 DM6A0X7 DI DM6A0X7 DM6A0X7 DN Pravastatin DM6A0X7 MI DE4LYSA DM6A0X7 MN Cytochrome P450 3A4 (CYP3A4) DM6A0X7 MT DME DM6A0X7 MA Metabolism DM6A0X7 RN Clinical pharmacokinetics of pravastatin: mechanisms of pharmacokinetic events. Clin Pharmacokinet. 2000 Dec;39(6):397-412. DM6A0X7 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=11192473 DM6A0X7 DI DM6A0X7 DM6A0X7 DN Pravastatin DM6A0X7 MI DEIBDNY DM6A0X7 MN Cytochrome P450 3A5 (CYP3A5) DM6A0X7 MT DME DM6A0X7 MA Metabolism DM6A0X7 RN Comparison of cytochrome P-450-dependent metabolism and drug interactions of the 3-hydroxy-3-methylglutaryl-CoA reductase inhibitors lovastatin and pravastatin in the liver. Drug Metab Dispos. 1999 Feb;27(2):173-9. DM6A0X7 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=9929499 DM6A0X7 DI DM6A0X7 DM6A0X7 DN Pravastatin DM6A0X7 MI TTPADOQ DM6A0X7 MN HMG-CoA reductase (HMGCR) DM6A0X7 MT DTT DM6A0X7 MA Inhibitor DM6A0X7 RN A randomized, double-blind trial comparing the efficacy and safety of pitavastatin versus pravastatin in patients with primary hypercholesterolemia. Atherosclerosis. 2002 Jun;162(2):373-9. DM6A0X7 RU https://pubmed.ncbi.nlm.nih.gov/11996957 DM6A0X7 DI DM6A0X7 DM6A0X7 DN Pravastatin DM6A0X7 MI DTFI42L DM6A0X7 MN Multidrug resistance-associated protein 2 (ABCC2) DM6A0X7 MT DTP DM6A0X7 MA Substrate DM6A0X7 RN Role of transporters in the tissue-selective distribution and elimination of drugs: transporters in the liver, small intestine, brain and kidney. J Control Release. 2002 Jan 17;78(1-3):43-54. DM6A0X7 RU http://www.ncbi.nlm.nih.gov/pubmed/11772448 DM6A0X7 DI DM6A0X7 DM6A0X7 DN Pravastatin DM6A0X7 MI DTVP67E DM6A0X7 MN Organic anion transporter 3 (SLC22A8) DM6A0X7 MT DTP DM6A0X7 MA Substrate DM6A0X7 RN Prediction of the overall renal tubular secretion and hepatic clearance of anionic drugs and a renal drug-drug interaction involving organic anion transporter 3 in humans by in vitro uptake experiments. Drug Metab Dispos. 2011 Jun;39(6):1031-8. DM6A0X7 RU http://www.ncbi.nlm.nih.gov/pubmed/21383204 DM6A0X7 DI DM6A0X7 DM6A0X7 DN Pravastatin DM6A0X7 MI DT06JWZ DM6A0X7 MN Organic anion transporter 4 (SLC22A11) DM6A0X7 MT DTP DM6A0X7 MA Substrate DM6A0X7 RN Inhibition of human organic anion transporter 3 mediated pravastatin transport by gemfibrozil and the metabolites in humans. Xenobiotica. 2007 Apr;37(4):416-26. DM6A0X7 RU http://www.ncbi.nlm.nih.gov/pubmed/17455113 DM6A0X7 DI DM6A0X7 DM6A0X7 DN Pravastatin DM6A0X7 MI DTDI5S3 DM6A0X7 MN Organic anion transporter 7 (SLC22A9) DM6A0X7 MT DTP DM6A0X7 MA Substrate DM6A0X7 RN Variability in hepatic expression of organic anion transporter 7/SLC22A9, a novel pravastatin uptake transporter: impact of genetic and regulatory factors. Pharmacogenomics J. 2016 Aug;16(4):341-51. DM6A0X7 RU http://www.ncbi.nlm.nih.gov/pubmed/26239079 DM6A0X7 DI DM6A0X7 DM6A0X7 DN Pravastatin DM6A0X7 MI DT3D8F0 DM6A0X7 MN Organic anion transporting polypeptide 1B1 (SLCO1B1) DM6A0X7 MT DTP DM6A0X7 MA Substrate DM6A0X7 RN The effect of SLCO1B1*15 on the disposition of pravastatin and pitavastatin is substrate dependent: the contribution of transporting activity changes by SLCO1B1*15. Pharmacogenet Genomics. 2008 May;18(5):424-33. DM6A0X7 RU http://www.ncbi.nlm.nih.gov/pubmed/18408565 DM6A0X7 DI DM6A0X7 DM6A0X7 DN Pravastatin DM6A0X7 MI DT9C1TS DM6A0X7 MN Organic anion transporting polypeptide 1B3 (SLCO1B3) DM6A0X7 MT DTP DM6A0X7 MA Substrate DM6A0X7 RN Relevance of conserved lysine and arginine residues in transmembrane helices for the transport activity of organic anion transporting polypeptide 1B3. Br J Pharmacol. 2010 Feb 1;159(3):698-708. DM6A0X7 RU http://www.ncbi.nlm.nih.gov/pubmed/20100277 DM6A0X7 DI DM6A0X7 DM6A0X7 DN Pravastatin DM6A0X7 MI DTPFTEQ DM6A0X7 MN Organic anion transporting polypeptide 2B1 (SLCO2B1) DM6A0X7 MT DTP DM6A0X7 MA Substrate DM6A0X7 RN Functional characterization of pH-sensitive organic anion transporting polypeptide OATP-B in human. J Pharmacol Exp Ther. 2004 Feb;308(2):438-45. DM6A0X7 RU http://www.ncbi.nlm.nih.gov/pubmed/14610227 DM6A0X7 DI DM6A0X7 DM6A0X7 DN Pravastatin DM6A0X7 MI DTUGYRD DM6A0X7 MN P-glycoprotein 1 (ABCB1) DM6A0X7 MT DTP DM6A0X7 MA Substrate DM6A0X7 RN Tarascon Pocket Pharmacopoeia 2018 Classic Shirt-Pocket Edition. DM6A0X7 RU https://books.google.com/books?id=0gBRDwAAQBAJ&pg=PP37&lpg=PP37&dq=Methylergonovine+transporter+uptake+efflex&source=bl&ots=cUTe_ppsmZ&sig=ACfU3U3E_YqrDg0CNEuj8K-7lci47HAnrg&hl=zh-CN&sa=X&ved=2ahUKEwjnj-Dk7d7iAhUsK6YKHd5DBDkQ6AEwEnoECAgQAQ#v=onepage&q&f=false DM6A0X7 DI DM6A0X7 DM6A0X7 DN Pravastatin DM6A0X7 MI DTHE530 DM6A0X7 MN Probable small intestine urate exporter (SLC17A4) DM6A0X7 MT DTP DM6A0X7 MA Substrate DM6A0X7 RN A Na+-phosphate cotransporter homologue (SLC17A4 protein) is an intestinal organic anion exporter. Am J Physiol Cell Physiol. 2012 Jun 1;302(11):C1652-60. DM6A0X7 RU http://www.ncbi.nlm.nih.gov/pubmed/22460716 DMEWC7N DI DMEWC7N DMEWC7N DN Prazepam DMEWC7N MI DE4LYSA DMEWC7N MN Cytochrome P450 3A4 (CYP3A4) DMEWC7N MT DME DMEWC7N MA Metabolism DMEWC7N RN Metabolic profile of oxazepam and related benzodiazepines: clinical and forensic aspects. Drug Metab Rev. 2017 Nov;49(4):451-463. DMEWC7N RU https://www.ncbi.nlm.nih.gov/pubmed/?term=28903606 DMEWC7N DI DMEWC7N DMEWC7N DN Prazepam DMEWC7N MI TTPTXIN DMEWC7N MN Translocator protein (TSPO) DMEWC7N MT DTT DMEWC7N MA Modulator DMEWC7N RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. DMEWC7N RU https://www.fda.gov/ DMOU1PK DI DMOU1PK DMOU1PK DN Praziquantel DMOU1PK MI DEJGDUW DMOU1PK MN Cytochrome P450 1A2 (CYP1A2) DMOU1PK MT DME DMOU1PK MA Metabolism DMOU1PK RN Identification of human cytochrome P(450)s that metabolise anti-parasitic drugs and predictions of in vivo drug hepatic clearance from in vitro data. Eur J Clin Pharmacol. 2003 Sep;59(5-6):429-42. DMOU1PK RU https://www.ncbi.nlm.nih.gov/pubmed/?term=12920490 DMOU1PK DI DMOU1PK DMOU1PK DN Praziquantel DMOU1PK MI DE4LYSA DMOU1PK MN Cytochrome P450 3A4 (CYP3A4) DMOU1PK MT DME DMOU1PK MA Metabolism DMOU1PK RN Biotransformation of praziquantel by human cytochrome p450 3A4 (CYP 3A4). Acta Pol Pharm. 2006 Sep-Oct;63(5):381-5. DMOU1PK RU https://www.ncbi.nlm.nih.gov/pubmed/?term=17357589 DMOU1PK DI DMOU1PK DMOU1PK DN Praziquantel DMOU1PK MI DEO1IE3 DMOU1PK MN Cytochrome P450 3A43 (CYP3A43) DMOU1PK MT DME DMOU1PK MA Metabolism DMOU1PK RN Rifampin markedly decreases plasma concentrations of praziquantel in healthy volunteers. Clin Pharmacol Ther. 2002 Nov;72(5):505-13. DMOU1PK RU https://www.ncbi.nlm.nih.gov/pubmed/?term=12426514 DMOU1PK DI DMOU1PK DMOU1PK DN Praziquantel DMOU1PK MI DEIBDNY DMOU1PK MN Cytochrome P450 3A5 (CYP3A5) DMOU1PK MT DME DMOU1PK MA Metabolism DMOU1PK RN Rifampin markedly decreases plasma concentrations of praziquantel in healthy volunteers. Clin Pharmacol Ther. 2002 Nov;72(5):505-13. DMOU1PK RU https://www.ncbi.nlm.nih.gov/pubmed/?term=12426514 DMOU1PK DI DMOU1PK DMOU1PK DN Praziquantel DMOU1PK MI DERD86B DMOU1PK MN Cytochrome P450 3A7 (CYP3A7) DMOU1PK MT DME DMOU1PK MA Metabolism DMOU1PK RN Rifampin markedly decreases plasma concentrations of praziquantel in healthy volunteers. Clin Pharmacol Ther. 2002 Nov;72(5):505-13. DMOU1PK RU https://www.ncbi.nlm.nih.gov/pubmed/?term=12426514 DMOU1PK DI DMOU1PK DMOU1PK DN Praziquantel DMOU1PK MI TTCYE56 DMOU1PK MN Glutathione-dependent PGD synthase (HPGDS) DMOU1PK MT DTT DMOU1PK MA Inhibitor DMOU1PK RN X-ray structure of glutathione S-transferase from Schistosoma japonicum in a new crystal form reveals flexibility of the substrate-binding site. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2005 Mar 1;61(Pt 3):263-5. DMOU1PK RU https://pubmed.ncbi.nlm.nih.gov/16511012 DMOU1PK DI DMOU1PK DMOU1PK DN Praziquantel DMOU1PK MI DEGTFWK DMOU1PK MN Mephenytoin 4-hydroxylase (CYP2C19) DMOU1PK MT DME DMOU1PK MA Metabolism DMOU1PK RN Identification of human cytochrome P(450)s that metabolise anti-parasitic drugs and predictions of in vivo drug hepatic clearance from in vitro data. Eur J Clin Pharmacol. 2003 Sep;59(5-6):429-42. DMOU1PK RU https://www.ncbi.nlm.nih.gov/pubmed/?term=12920490 DMCD9YG DI DMCD9YG DMCD9YG DN Prazosin DMCD9YG MI TTG28O6 DMCD9YG MN Adrenergic receptor Alpha-1 (ADRA1) DMCD9YG MT DTT DMCD9YG MA Antagonist DMCD9YG RN Adventitia removal does not modify the alphaID-adrenoceptors response in aorta during hypertension and ageing. Auton Autacoid Pharmacol. 2009 Jul;29(3):117-33. DMCD9YG RU https://pubmed.ncbi.nlm.nih.gov/19566752 DMCD9YG DI DMCD9YG DMCD9YG DN Prazosin DMCD9YG MI DTI7UX6 DMCD9YG MN Breast cancer resistance protein (ABCG2) DMCD9YG MT DTP DMCD9YG MA Substrate DMCD9YG RN P-glycoprotein and breast cancer resistance protein expression and function at the blood-brain barrier and blood-cerebrospinal fluid barrier (choroid plexus) in streptozotocin-induced diabetes in rats. Brain Res. 2011 Jan 25;1370:238-45. DMCD9YG RU http://www.ncbi.nlm.nih.gov/pubmed/21075088 DMCD9YG DI DMCD9YG DMCD9YG DN Prazosin DMCD9YG MI DE6OQ3W DMCD9YG MN Cytochrome P450 1A1 (CYP1A1) DMCD9YG MT DME DMCD9YG MA Metabolism DMCD9YG RN Role of adrenoceptor-linked signaling pathways in the regulation of CYP1A1 gene expression. Biochem Pharmacol. 2005 Jan 15;69(2):277-87. DMCD9YG RU https://www.ncbi.nlm.nih.gov/pubmed/?term=15627480 DMCD9YG DI DMCD9YG DMCD9YG DN Prazosin DMCD9YG MI DTT79CX DMCD9YG MN Organic cation transporter 1 (SLC22A1) DMCD9YG MT DTP DMCD9YG MA Substrate DMCD9YG RN Implications of genetic polymorphisms in drug transporters for pharmacotherapy. Cancer Lett. 2006 Mar 8;234(1):4-33. DMCD9YG RU https://doi.org/10.1016/j.canlet.2005.06.051 DMCD9YG DI DMCD9YG DMCD9YG DN Prazosin DMCD9YG MI DTUGYRD DMCD9YG MN P-glycoprotein 1 (ABCB1) DMCD9YG MT DTP DMCD9YG MA Substrate DMCD9YG RN Evidence for two nonidentical drug-interaction sites in the human P-glycoprotein. Proc Natl Acad Sci U S A. 1997 Sep 30;94(20):10594-9. DMCD9YG RU http://www.ncbi.nlm.nih.gov/pubmed/9380680 DMBUNVW DI DMBUNVW DMBUNVW DN Prednicarbate DMBUNVW MI DE4LYSA DMBUNVW MN Cytochrome P450 3A4 (CYP3A4) DMBUNVW MT DME DMBUNVW MA Metabolism DMBUNVW RN HEP Drug interaction: daclatasvir and abacavir. DMBUNVW RU https://hep-druginteractions.org/interactions/1205/all DMBUNVW DI DMBUNVW DMBUNVW DN Prednicarbate DMBUNVW MI TTP3UTW DMBUNVW MN Steroid hormone receptor ERR (ESRR) DMBUNVW MT DTT DMBUNVW MA Modulator DMBUNVW RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. DMBUNVW RU https://www.fda.gov/ DMQ8FR2 DI DMQ8FR2 DMQ8FR2 DN Prednisolone DMQ8FR2 MI DE4LYSA DMQ8FR2 MN Cytochrome P450 3A4 (CYP3A4) DMQ8FR2 MT DME DMQ8FR2 MA Metabolism DMQ8FR2 RN Inter-individual difference determinant of prednisolone pharmacokinetics for Japanese renal transplant recipients in the maintenance stage. Xenobiotica. 2009 Dec;39(12):939-45. DMQ8FR2 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=19795924 DMQ8FR2 DI DMQ8FR2 DMQ8FR2 DN Prednisolone DMQ8FR2 MI DEIBDNY DMQ8FR2 MN Cytochrome P450 3A5 (CYP3A5) DMQ8FR2 MT DME DMQ8FR2 MA Metabolism DMQ8FR2 RN Pharmacokinetic and pharmacoimmunodynamic interactions between prednisolone and sirolimus in adrenalectomized rats. J Pharmacokinet Biopharm. 1999 Feb;27(1):1-21. DMQ8FR2 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=10533695 DMQ8FR2 DI DMQ8FR2 DMQ8FR2 DN Prednisolone DMQ8FR2 MI TTYRL6O DMQ8FR2 MN Glucocorticoid receptor (NR3C1) DMQ8FR2 MT DTT DMQ8FR2 MA Modulator DMQ8FR2 RN Aldosterone (mineralocorticoid) equivalent to prednisolone (glucocorticoid) in reversing hearing loss in MRL/MpJ-Fas1pr autoimmune mice. Laryngoscope. 2000 Nov;110(11):1902-6. DMQ8FR2 RU https://pubmed.ncbi.nlm.nih.gov/11081607 DMQ8FR2 DI DMQ8FR2 DMQ8FR2 DN Prednisolone DMQ8FR2 MI DTUGYRD DMQ8FR2 MN P-glycoprotein 1 (ABCB1) DMQ8FR2 MT DTP DMQ8FR2 MA Substrate DMQ8FR2 RN The role of the efflux transporter P-glycoprotein in brain penetration of prednisolone. J Endocrinol. 2002 Oct;175(1):251-60. DMQ8FR2 RU http://www.ncbi.nlm.nih.gov/pubmed/12379510 DM2HG4X DI DM2HG4X DM2HG4X DN Prednisone DM2HG4X MI DE4LYSA DM2HG4X MN Cytochrome P450 3A4 (CYP3A4) DM2HG4X MT DME DM2HG4X MA Metabolism DM2HG4X RN Cytochrome P450 enzyme regulation by glucocorticoids and consequences in terms of drug interaction. Expert Opin Drug Metab Toxicol. 2014 Mar;10(3):425-35. DM2HG4X RU https://www.ncbi.nlm.nih.gov/pubmed/?term=24451000 DM2HG4X DI DM2HG4X DM2HG4X DN Prednisone DM2HG4X MI TTYRL6O DM2HG4X MN Glucocorticoid receptor (NR3C1) DM2HG4X MT DTT DM2HG4X MA Agonist DM2HG4X RN Cytochromes P450 (CYP) in the Poeciliopsis lucida hepatocellular carcinoma cell line (PLHC-1): dose- and time-dependent glucocorticoid potentiation of CYP1A induction without induction of CYP3A. ArchBiochem Biophys. 1996 May 1;329(1):113-22. DM2HG4X RU https://pubmed.ncbi.nlm.nih.gov/8619627 DM2HG4X DI DM2HG4X DM2HG4X DN Prednisone DM2HG4X MI DTUGYRD DM2HG4X MN P-glycoprotein 1 (ABCB1) DM2HG4X MT DTP DM2HG4X MA Substrate DM2HG4X RN Structural determinants of P-glycoprotein-mediated transport of glucocorticoids. Pharm Res. 2003 Nov;20(11):1794-803. DM2HG4X RU http://www.ncbi.nlm.nih.gov/pubmed/14661924 DMDVP3B DI DMDVP3B DMDVP3B DN Pregabalin DMDVP3B MI DT48T0N DMDVP3B MN L-type amino acid transporter 1 (SLC7A5) DMDVP3B MT DTP DMDVP3B MA Substrate DMDVP3B RN Transport of Pregabalin Via L-Type Amino Acid Transporter 1 (SLC7A5) in Human Brain Capillary Endothelial Cell Line. Pharm Res. 2018 Oct 29;35(12):246. DMDVP3B RU http://www.ncbi.nlm.nih.gov/pubmed/30374619 DMDVP3B DI DMDVP3B DMDVP3B DN Pregabalin DMDVP3B MI TTFK1JQ DMDVP3B MN Voltage-gated calcium channel alpha-2/delta-1 (CACNA2D1) DMDVP3B MT DTT DMDVP3B MA Modulator DMDVP3B RN Pregabalin reduces the release of synaptic vesicles from cultured hippocampal neurons. Mol Pharmacol. 2006 Aug;70(2):467-76. DMDVP3B RU https://pubmed.ncbi.nlm.nih.gov/16641316 DMYQVGN DI DMYQVGN DMYQVGN DN Premarin/Trimegestone DMYQVGN MI TTZAYWL DMYQVGN MN Estrogen receptor (ESR) DMYQVGN MT DTT DMYQVGN MA Modulator DMYQVGN RN The Haunting of Medical Journals: How Ghostwriting Sold RT PLoS Med. 2010 September; 7(9): e1000335. DMYQVGN RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2935455/ DMDYA31 DI DMDYA31 DMDYA31 DN Pretomanid DMDYA31 MI DE4LYSA DMDYA31 MN Cytochrome P450 3A4 (CYP3A4) DMDYA31 MT DME DMDYA31 MA Metabolism DMDYA31 RN FDA briefing document - pretomanid tablet, 200 mg meeting of the antimicrobial drugs advisory committee (AMDAC). DMDYA31 RU https://www.fda.gov/media/127592/download DMDYA31 DI DMDYA31 DMDYA31 DN Pretomanid DMDYA31 MI TT08ESN DMDYA31 MN Mycobacterium Mycolic acid synthase (MycB cma) DMDYA31 MT DTT DMDYA31 MA Inhibitor DMDYA31 RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health Human Services. 2019 DMDYA31 RU https://www.accessdata.fda.gov/drugsatfda_docs/nda/2019/212862Orig1s000Lbl.pdf DMQ0C2Z DI DMQ0C2Z DMQ0C2Z DN Prevnar DMQ0C2Z MI TT9GOIR DMQ0C2Z MN Streptococcus Diphtheria protein (Stre DIPP) DMQ0C2Z MT DTT DMQ0C2Z RN Patent WO2013131983 A1. DMQ0C2Z RU http://www.google.com/patents/WO2013131983A1?cl=en DMMZB0K DI DMMZB0K DMMZB0K DN Prifinium DMMZB0K MI TTH18TF DMMZB0K MN Muscarinic acetylcholine receptor M5 (CHRM5) DMMZB0K MT DTT DMMZB0K MA Modulator DMMZB0K RN Ligand binding properties of muscarinic acetylcholine receptor subtypes (m1-m5) expressed in baculovirus-infected insect cells. J Pharmacol Exp Ther. 1995 Jul;274(1):378-84. DMMZB0K RU https://pubmed.ncbi.nlm.nih.gov/7616422 DMI7DZ2 DI DMI7DZ2 DMI7DZ2 DN Prilocaine DMI7DZ2 MI TTZOVE0 DMI7DZ2 MN Voltage-gated sodium channel alpha Nav1.5 (SCN5A) DMI7DZ2 MT DTT DMI7DZ2 MA Blocker DMI7DZ2 RN Monoamine transporter and sodium channel mechanisms in the rapid pressor response to cocaine. Pharmacol Biochem Behav. 1998 Feb;59(2):305-12. DMI7DZ2 RU https://pubmed.ncbi.nlm.nih.gov/9476974 DMWQ16I DI DMWQ16I DMWQ16I DN Primaquine DMWQ16I MI DEJGDUW DMWQ16I MN Cytochrome P450 1A2 (CYP1A2) DMWQ16I MT DME DMWQ16I MA Metabolism DMWQ16I RN Identification of human cytochrome P(450)s that metabolise anti-parasitic drugs and predictions of in vivo drug hepatic clearance from in vitro data. Eur J Clin Pharmacol. 2003 Sep;59(5-6):429-42. DMWQ16I RU https://www.ncbi.nlm.nih.gov/pubmed/?term=12920490 DMWQ16I DI DMWQ16I DMWQ16I DN Primaquine DMWQ16I MI DE4LYSA DMWQ16I MN Cytochrome P450 3A4 (CYP3A4) DMWQ16I MT DME DMWQ16I MA Metabolism DMWQ16I RN Primaquine metabolism by human liver microsomes: effect of other antimalarial drugs. Biochem Pharmacol. 1992 Aug 4;44(3):587-90. DMWQ16I RU https://www.ncbi.nlm.nih.gov/pubmed/?term=1510705 DMWQ16I DI DMWQ16I DMWQ16I DN Primaquine DMWQ16I MI TT698WO DMWQ16I MN Plasmodium Deoxyribonucleic acid (Malaria DNA) DMWQ16I MT DTT DMWQ16I RN Primaquine-induced differential gene expression analysis in mice liver using DNA microarrays. Toxicology. 2007 Sep 24;239(1-2):96-107. DMWQ16I RU https://pubmed.ncbi.nlm.nih.gov/17686563 DM0WX6I DI DM0WX6I DM0WX6I DN Primidone DM0WX6I MI DE5IED8 DM0WX6I MN Cytochrome P450 2C9 (CYP2C9) DM0WX6I MT DME DM0WX6I MA Metabolism DM0WX6I RN Prescribrt's digital referenve - Primidone - Drug Summary. DM0WX6I RU https://www.pdr.net/drug-summary/Mysoline-primidone-775 DM0WX6I DI DM0WX6I DM0WX6I DN Primidone DM0WX6I MI TT1MPAY DM0WX6I MN GABA(A) receptor alpha-1 (GABRA1) DM0WX6I MT DTT DM0WX6I MA Antagonist DM0WX6I RN DrugBank: a knowledgebase for drugs, drug actions and drug targets. Nucleic Acids Res. 2008 Jan;36(Database issue):D901-6. DM0WX6I RU https://pubmed.ncbi.nlm.nih.gov/18048412 DM0WX6I DI DM0WX6I DM0WX6I DN Primidone DM0WX6I MI DEGTFWK DM0WX6I MN Mephenytoin 4-hydroxylase (CYP2C19) DM0WX6I MT DME DM0WX6I MA Metabolism DM0WX6I RN Clinically significant pharmacokinetic drug interactions between antiepileptic drugs. J Clin Pharm Ther. 1999 Apr;24(2):87-92. DM0WX6I RU https://www.ncbi.nlm.nih.gov/pubmed/?term=10380060 DM9HOKG DI DM9HOKG DM9HOKG DN Prinomastat DM9HOKG MI TTMX39J DM9HOKG MN Matrix metalloproteinase-1 (MMP-1) DM9HOKG MT DTT DM9HOKG MA Inhibitor DM9HOKG RN AG-3340 (Agouron Pharmaceuticals Inc). IDrugs. 2000 Mar;3(3):336-45. DM9HOKG RU https://pubmed.ncbi.nlm.nih.gov/16103944 DM9HOKG DI DM9HOKG DM9HOKG DN Prinomastat DM9HOKG MI TTLM12X DM9HOKG MN Matrix metalloproteinase-2 (MMP-2) DM9HOKG MT DTT DM9HOKG MA Inhibitor DM9HOKG RN AG-3340 (Agouron Pharmaceuticals Inc). IDrugs. 2000 Mar;3(3):336-45. DM9HOKG RU https://pubmed.ncbi.nlm.nih.gov/16103944 DM9HOKG DI DM9HOKG DM9HOKG DN Prinomastat DM9HOKG MI TTMTWOS DM9HOKG MN Matrix metalloproteinase-7 (MMP-7) DM9HOKG MT DTT DM9HOKG MA Inhibitor DM9HOKG RN AG-3340 (Agouron Pharmaceuticals Inc). IDrugs. 2000 Mar;3(3):336-45. DM9HOKG RU https://pubmed.ncbi.nlm.nih.gov/16103944 DMMFWOJ DI DMMFWOJ DMMFWOJ DN Probenecid DMMFWOJ MI DT3I124 DMMFWOJ MN Monocarboxylate transporter 6 (SLC16A5) DMMFWOJ MT DTP DMMFWOJ MA Substrate DMMFWOJ RN Quercetin, Morin, Luteolin, and Phloretin Are Dietary Flavonoid Inhibitors of Monocarboxylate Transporter 6. Mol Pharm. 2017 Sep 5;14(9):2930-2936. DMMFWOJ RU http://www.ncbi.nlm.nih.gov/pubmed/28513167 DMMFWOJ DI DMMFWOJ DMMFWOJ DN Probenecid DMMFWOJ MI DTFI42L DMMFWOJ MN Multidrug resistance-associated protein 2 (ABCC2) DMMFWOJ MT DTP DMMFWOJ MA Substrate DMMFWOJ RN MRP2 (ABCC2) transports taxanes and confers paclitaxel resistance and both processes are stimulated by probenecid. Int J Cancer. 2005 Sep 20;116(5):824-9. DMMFWOJ RU https://doi.org/10.1002/ijc.21013 DMMFWOJ DI DMMFWOJ DMMFWOJ DN Probenecid DMMFWOJ MI DTE2B1D DMMFWOJ MN Organic anion transporting polypeptide 1A2 (SLCO1A2) DMMFWOJ MT DTP DMMFWOJ MA Substrate DMMFWOJ RN Characterization of the efflux transport of 17beta-estradiol-D-17beta-glucuronide from the brain across the blood-brain barrier. J Pharmacol Exp Ther. 2001 Jul;298(1):316-22. DMMFWOJ RU http://www.ncbi.nlm.nih.gov/pubmed/11408557 DMMFWOJ DI DMMFWOJ DMMFWOJ DN Probenecid DMMFWOJ MI TTTQR47 DMMFWOJ MN Solute carrier family 22 member 8 (SLC22A8) DMMFWOJ MT DTT DMMFWOJ MA Blocker DMMFWOJ RN Transport of organic anions across the basolateral membrane of proximal tubule cells. Rev Physiol Biochem Pharmacol. 2003;146:95-158. DMMFWOJ RU https://pubmed.ncbi.nlm.nih.gov/12605306 DMMFWOJ DI DMMFWOJ DMMFWOJ DN Probenecid DMMFWOJ MI DEYGVN4 DMMFWOJ MN UDP-glucuronosyltransferase 1A1 (UGT1A1) DMMFWOJ MT DME DMMFWOJ MA Metabolism DMMFWOJ RN Modulation of 3'-azido-3'-deoxythymidine catabolism by probenecid and acetaminophen in freshly isolated rat hepatocytes. Biochem Pharmacol. 1991 Sep 12;42(7):1475-80. DMMFWOJ RU https://www.ncbi.nlm.nih.gov/pubmed/?term=1930271 DMVZQ2M DI DMVZQ2M DMVZQ2M DN Probucol DMVZQ2M MI TTJW1GN DMVZQ2M MN ATP-binding cassette transporter A1 (ABCA1) DMVZQ2M MT DTT DMVZQ2M MA Modulator DMVZQ2M RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. DMVZQ2M RU https://www.fda.gov/ DMNMXR8 DI DMNMXR8 DMNMXR8 DN Procainamide DMNMXR8 MI DECB0K3 DMNMXR8 MN Cytochrome P450 2D6 (CYP2D6) DMNMXR8 MT DME DMNMXR8 MA Metabolism DMNMXR8 RN Involvement of CYP2D6 activity in the N-oxidation of procainamide in man. Pharmacogenetics. 1999 Dec;9(6):683-96. DMNMXR8 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=10634131 DMNMXR8 DI DMNMXR8 DMNMXR8 DN Procainamide DMNMXR8 MI TT05DLS DMNMXR8 MN E3 ubiquitin-protein ligase COP1 (RFWD2) DMNMXR8 MT DTT DMNMXR8 MA Modulator DMNMXR8 RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. DMNMXR8 RU https://www.fda.gov/ DMNMXR8 DI DMNMXR8 DMNMXR8 DN Procainamide DMNMXR8 MI DTZGT0P DMNMXR8 MN Multidrug and toxin extrusion protein 1 (SLC47A1) DMNMXR8 MT DTP DMNMXR8 MA Substrate DMNMXR8 RN Substrate specificity of MATE1 and MATE2-K, human multidrug and toxin extrusions/H(+)-organic cation antiporters. Biochem Pharmacol. 2007 Jul 15;74(2):359-71. DMNMXR8 RU http://www.ncbi.nlm.nih.gov/pubmed/17509534 DMNMXR8 DI DMNMXR8 DMNMXR8 DN Procainamide DMNMXR8 MI DT3TX4H DMNMXR8 MN Multidrug and toxin extrusion protein 2 (SLC47A2) DMNMXR8 MT DTP DMNMXR8 MA Substrate DMNMXR8 RN Substrate specificity of MATE1 and MATE2-K, human multidrug and toxin extrusions/H(+)-organic cation antiporters. Biochem Pharmacol. 2007 Jul 15;74(2):359-71. DMNMXR8 RU http://www.ncbi.nlm.nih.gov/pubmed/17509534 DMNMXR8 DI DMNMXR8 DMNMXR8 DN Procainamide DMNMXR8 MI DE7OAB3 DMNMXR8 MN N-acetyltransferase 1 (NAT1) DMNMXR8 MT DME DMNMXR8 MA Metabolism DMNMXR8 RN Longitudinal distribution of arylamine N-acetyltransferases in the intestine of the hamster, mouse, and rat. Evidence for multiplicity of N-acetyltransferases in the intestine. Biochem Pharmacol. 1996 Nov 22;52(10):1613-20. DMNMXR8 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=8937477 DMNMXR8 DI DMNMXR8 DMNMXR8 DN Procainamide DMNMXR8 MI DER7TA0 DMNMXR8 MN N-acetyltransferase 2 (NAT2) DMNMXR8 MT DME DMNMXR8 MA Metabolism DMNMXR8 RN Substrate-dependent regulation of human arylamine N-acetyltransferase-1 in cultured cells. Mol Pharmacol. 2000 Mar;57(3):468-73. DMNMXR8 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=10692486 DMNMXR8 DI DMNMXR8 DMNMXR8 DN Procainamide DMNMXR8 MI DTT79CX DMNMXR8 MN Organic cation transporter 1 (SLC22A1) DMNMXR8 MT DTP DMNMXR8 MA Substrate DMNMXR8 RN Identification of novel substrates and structure-activity relationship of cellular uptake mediated by human organic cation transporters 1 and 2. J Med Chem. 2013 Sep 26;56(18):7232-42. DMNMXR8 RU http://www.ncbi.nlm.nih.gov/pubmed/23984907 DMNMXR8 DI DMNMXR8 DMNMXR8 DN Procainamide DMNMXR8 MI DEZV4AP DMNMXR8 MN RNA cytidine acetyltransferase (hALP) DMNMXR8 MT DME DMNMXR8 MA Metabolism DMNMXR8 RN Effect of H2-receptor antagonists on rat liver cytosolic acetyl CoA:arylamine N-acetyltransferase activity. Drug Metab Dispos. 1992 Jan-Feb;20(1):74-8. DMNMXR8 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=1371435 DM4LSNE DI DM4LSNE DM4LSNE DN Procaine DM4LSNE MI TTPC4TU DM4LSNE MN 5-HT 3A receptor (HTR3A) DM4LSNE MT DTT DM4LSNE MA Antagonist DM4LSNE RN Local anesthetics have different mechanisms and sites of action at recombinant 5-HT3 receptors. Reg Anesth Pain Med. 2007 Nov-Dec;32(6):462-70. DM4LSNE RU https://pubmed.ncbi.nlm.nih.gov/18035290 DMIK367 DI DMIK367 DMIK367 DN Procarbazine DMIK367 MI DE6OQ3W DMIK367 MN Cytochrome P450 1A1 (CYP1A1) DMIK367 MT DME DMIK367 MA Metabolism DMIK367 RN In vitro and in vivo evidence for the formation of methyl radical from procarbazine: a spin-trapping study. Carcinogenesis. 1992 May;13(5):799-805. DMIK367 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=1316811 DMIK367 DI DMIK367 DMIK367 DN Procarbazine DMIK367 MI DEJGDUW DMIK367 MN Cytochrome P450 1A2 (CYP1A2) DMIK367 MT DME DMIK367 MA Metabolism DMIK367 RN In vitro and in vivo evidence for the formation of methyl radical from procarbazine: a spin-trapping study. Carcinogenesis. 1992 May;13(5):799-805. DMIK367 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=1316811 DMIK367 DI DMIK367 DMIK367 DN Procarbazine DMIK367 MI DE9QHP6 DMIK367 MN Cytochrome P450 1B1 (CYP1B1) DMIK367 MT DME DMIK367 MA Metabolism DMIK367 RN Tumour cytochrome P450 and drug activation. Curr Pharm Des. 2002;8(15):1335-47. DMIK367 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=12052211 DMIK367 DI DMIK367 DMIK367 DN Procarbazine DMIK367 MI TTUTN1I DMIK367 MN Human Deoxyribonucleic acid (hDNA) DMIK367 MT DTT DMIK367 RN Brca2/Xrcc2 dependent HR, but not NHEJ, is required for protection against O(6)-methylguanine triggered apoptosis, DSBs and chromosomal aberrations... DNA Repair (Amst). 2009 Jan 1;8(1):72-86. DMIK367 RU https://pubmed.ncbi.nlm.nih.gov/18840549 DM1M0Q4 DI DM1M0Q4 DM1M0Q4 DN Procaterol DM1M0Q4 MI TT2CJVK DM1M0Q4 MN Adrenergic receptor beta-2 (ADRB2) DM1M0Q4 MT DTT DM1M0Q4 MA Agonist DM1M0Q4 RN Inhalation and incubation with procaterol increases diaphragm muscle contractility in mice. Allergol Int. 2007 Sep;56(3):285-91. DM1M0Q4 RU https://pubmed.ncbi.nlm.nih.gov/17646734 DM1M0Q4 DI DM1M0Q4 DM1M0Q4 DN Procaterol DM1M0Q4 MI DTT79CX DM1M0Q4 MN Organic cation transporter 1 (SLC22A1) DM1M0Q4 MT DTP DM1M0Q4 MA Substrate DM1M0Q4 RN Identification of novel substrates and structure-activity relationship of cellular uptake mediated by human organic cation transporters 1 and 2. J Med Chem. 2013 Sep 26;56(18):7232-42. DM1M0Q4 RU http://www.ncbi.nlm.nih.gov/pubmed/23984907 DM53SRA DI DM53SRA DM53SRA DN Prochlorperazine DM53SRA MI DECB0K3 DM53SRA MN Cytochrome P450 2D6 (CYP2D6) DM53SRA MT DME DM53SRA MA Metabolism DM53SRA RN Potential for drug interactions involving cytochromes P450 2D6 and 3A4 on general adult psychiatric and functional elderly psychiatric wards. Br J Clin Pharmacol. 2004 Apr;57(4):464-72. DM53SRA RU https://www.ncbi.nlm.nih.gov/pubmed/?term=15025745 DM53SRA DI DM53SRA DM53SRA DN Prochlorperazine DM53SRA MI TTEX248 DM53SRA MN Dopamine D2 receptor (D2R) DM53SRA MT DTT DM53SRA MA Antagonist DM53SRA RN In vitro and in vivo characteristics of prochlorperazine oral disintegrating film. Int J Pharm. 2009 Feb 23;368(1-2):98-102. DM53SRA RU https://pubmed.ncbi.nlm.nih.gov/18992311 DMHFJDT DI DMHFJDT DMHFJDT DN Procyclidine DMHFJDT MI TTH18TF DMHFJDT MN Muscarinic acetylcholine receptor M5 (CHRM5) DMHFJDT MT DTT DMHFJDT MA Antagonist DMHFJDT RN Protection against soman-induced seizures in rats: relationship among doses of prophylactics, soman, and adjuncts. Toxicol Appl Pharmacol. 2004 May 1;196(3):327-36. DMHFJDT RU https://pubmed.ncbi.nlm.nih.gov/15094303 DMF1X5P DI DMF1X5P DMF1X5P DN Proflavine DMF1X5P MI TTS1W4A DMF1X5P MN Bacterial Deoxyribonucleic acid (Bact DNA) DMF1X5P MT DTT DMF1X5P MA Binder DMF1X5P RN Interaction of small molecules with double-stranded RNA: spectroscopic, viscometric, and calorimetric study of hoechst and proflavine binding to PolyCG structures. DNA Cell Biol. 2009 Apr;28(4):209-19. DMF1X5P RU https://pubmed.ncbi.nlm.nih.gov/19364280 DM671NG DI DM671NG DM671NG DN Progabide DM671NG MI TTDCVZW DM671NG MN Gamma-aminobutyric acid B receptor (GABBR) DM671NG MT DTT DM671NG MA Agonist DM671NG RN Interactions between dopamine and GABA in the control of ambulatory activity and neophobia in the mouse. Pharmacol Biochem Behav. 1998 Jan;59(1):239-47. DM671NG RU https://pubmed.ncbi.nlm.nih.gov/9443561 DMUY35B DI DMUY35B DMUY35B DN Progesterone DMUY35B MI DE7P2FB DMUY35B MN Aldo-keto reductase 1C1 (AKR1C1) DMUY35B MT DME DMUY35B MA Metabolism DMUY35B RN Human 3-alpha hydroxysteroid dehydrogenase type 3 (3alpha-HSD3): the V54L mutation restricting the steroid alternative binding and enhancing the 20alpha-HSD activity. J Steroid Biochem Mol Biol. 2014 May;141:135-43. DMUY35B RU https://www.ncbi.nlm.nih.gov/pubmed/?term=24434280 DMUY35B DI DMUY35B DMUY35B DN Progesterone DMUY35B MI DTI7UX6 DMUY35B MN Breast cancer resistance protein (ABCG2) DMUY35B MT DTP DMUY35B MA Substrate DMUY35B RN Sterol transport by the human breast cancer resistance protein (ABCG2) expressed in Lactococcus lactis. J Biol Chem. 2003 Jun 6;278(23):20645-51. DMUY35B RU http://www.ncbi.nlm.nih.gov/pubmed/12668685 DMUY35B DI DMUY35B DMUY35B DN Progesterone DMUY35B MI DEKP5HX DMUY35B MN Cholesterol 24-hydroxylase (CYP46A1) DMUY35B MT DME DMUY35B MA Metabolism DMUY35B RN Broad substrate specificity of human cytochrome P450 46A1 which initiates cholesterol degradation in the brain. Biochemistry. 2003 Dec 9;42(48):14284-92. DMUY35B RU https://www.ncbi.nlm.nih.gov/pubmed/?term=14640697 DMUY35B DI DMUY35B DMUY35B DN Progesterone DMUY35B MI DE6OQ3W DMUY35B MN Cytochrome P450 1A1 (CYP1A1) DMUY35B MT DME DMUY35B MA Metabolism DMUY35B RN Allelic variants of human cytochrome P450 1A1 (CYP1A1): effect of T461N and I462V substitutions on steroid hydroxylase specificity. Pharmacogenetics. 2000 Aug;10(6):519-30. DMUY35B RU https://www.ncbi.nlm.nih.gov/pubmed/?term=10975606 DMUY35B DI DMUY35B DMUY35B DN Progesterone DMUY35B MI DE9QHP6 DMUY35B MN Cytochrome P450 1B1 (CYP1B1) DMUY35B MT DME DMUY35B MA Metabolism DMUY35B RN Catalytic properties of polymorphic human cytochrome P450 1B1 variants. Carcinogenesis. 1999 Aug;20(8):1607-13. DMUY35B RU https://www.ncbi.nlm.nih.gov/pubmed/?term=10426814 DMUY35B DI DMUY35B DMUY35B DN Progesterone DMUY35B MI DEBY951 DMUY35B MN Cytochrome P450 21A2 (cyp21) DMUY35B MT DME DMUY35B MA Metabolism DMUY35B RN acillus megaterium SF185 spores exert protective effects against oxidative stress in vivo and in vitro. Sci Rep. 2019 Aug 19;9(1):12082. DMUY35B RU https://pubmed.ncbi.nlm.nih.gov/31427655 DMUY35B DI DMUY35B DMUY35B DN Progesterone DMUY35B MI DEJVYAZ DMUY35B MN Cytochrome P450 2A6 (CYP2A6) DMUY35B MT DME DMUY35B MA Metabolism DMUY35B RN Summary of information on human CYP enzymes: human P450 metabolism data. Drug Metab Rev. 2002 Feb-May;34(1-2):83-448. DMUY35B RU https://www.ncbi.nlm.nih.gov/pubmed/?term=11996015 DMUY35B DI DMUY35B DMUY35B DN Progesterone DMUY35B MI DE5IED8 DMUY35B MN Cytochrome P450 2C9 (CYP2C9) DMUY35B MT DME DMUY35B MA Metabolism DMUY35B RN Progesterone and testosterone hydroxylation by cytochromes P450 2C19, 2C9, and 3A4 in human liver microsomes. Arch Biochem Biophys. 1997 Oct 1;346(1):161-9. DMUY35B RU https://www.ncbi.nlm.nih.gov/pubmed/?term=9328296 DMUY35B DI DMUY35B DMUY35B DN Progesterone DMUY35B MI DECB0K3 DMUY35B MN Cytochrome P450 2D6 (CYP2D6) DMUY35B MT DME DMUY35B MA Metabolism DMUY35B RN Effect of genetic polymorphism on the metabolism of endogenous neuroactive substances, progesterone and p-tyramine, catalyzed by CYP2D6. Brain Res Mol Brain Res. 2004 Oct 22;129(1-2):117-23. DMUY35B RU https://www.ncbi.nlm.nih.gov/pubmed/?term=15469888 DMUY35B DI DMUY35B DMUY35B DN Progesterone DMUY35B MI DE4LYSA DMUY35B MN Cytochrome P450 3A4 (CYP3A4) DMUY35B MT DME DMUY35B MA Metabolism DMUY35B RN Contribution of human hepatic cytochrome P450 isoforms to regioselective hydroxylation of steroid hormones. Xenobiotica. 1998 Jun;28(6):539-47. DMUY35B RU https://www.ncbi.nlm.nih.gov/pubmed/?term=9667077 DMUY35B DI DMUY35B DMUY35B DN Progesterone DMUY35B MI DEIBDNY DMUY35B MN Cytochrome P450 3A5 (CYP3A5) DMUY35B MT DME DMUY35B MA Metabolism DMUY35B RN Human prostate CYP3A5: identification of a unique 5'-untranslated sequence and characterization of purified recombinant protein. Biochem Biophys Res Commun. 1999 Jul 14;260(3):676-81. DMUY35B RU https://www.ncbi.nlm.nih.gov/pubmed/?term=10403825 DMUY35B DI DMUY35B DMUY35B DN Progesterone DMUY35B MI DERD86B DMUY35B MN Cytochrome P450 3A7 (CYP3A7) DMUY35B MT DME DMUY35B MA Metabolism DMUY35B RN The role of cytochrome P450 3A (CYP3A) isoform(s) in oxidative metabolism of testosterone and benzphetamine in human adult and fetal liver. J Steroid Biochem Mol Biol. 1993 Jan;44(1):61-7. DMUY35B RU https://www.ncbi.nlm.nih.gov/pubmed/?term=8424894 DMUY35B DI DMUY35B DMUY35B DN Progesterone DMUY35B MI DEMF740 DMUY35B MN Cytochrome P450 4B1 (CYP4B1) DMUY35B MT DME DMUY35B MA Metabolism DMUY35B RN Steroid hormone hydroxylase specificities of eleven cDNA-expressed human cytochrome P450s. Arch Biochem Biophys. 1991 Oct;290(1):160-6. DMUY35B RU https://www.ncbi.nlm.nih.gov/pubmed/?term=1898086 DMUY35B DI DMUY35B DMUY35B DN Progesterone DMUY35B MI DEZ1H4L DMUY35B MN Cytochrome P450 MEG (cyp106) DMUY35B MT DME DMUY35B MA Metabolism DMUY35B RN Engineering of CYP106A2 for steroid 9alpha- and 6beta-hydroxylation. Steroids. 2017 Apr;120:41-48. DMUY35B RU https://pubmed.ncbi.nlm.nih.gov/28163026 DMUY35B DI DMUY35B DMUY35B DN Progesterone DMUY35B MI DE4ZHS1 DMUY35B MN Glutathione S-transferase alpha-1 (GSTA1) DMUY35B MT DME DMUY35B MA Metabolism DMUY35B RN Human glutathione transferase A3-3, a highly efficient catalyst of double-bond isomerization in the biosynthetic pathway of steroid hormones. J Biol Chem. 2001 Aug 31;276(35):33061-5. DMUY35B RU https://www.ncbi.nlm.nih.gov/pubmed/?term=11418619 DMUY35B DI DMUY35B DMUY35B DN Progesterone DMUY35B MI DEGTFWK DMUY35B MN Mephenytoin 4-hydroxylase (CYP2C19) DMUY35B MT DME DMUY35B MA Metabolism DMUY35B RN Progesterone and testosterone hydroxylation by cytochromes P450 2C19, 2C9, and 3A4 in human liver microsomes. Arch Biochem Biophys. 1997 Oct 1;346(1):161-9. DMUY35B RU https://www.ncbi.nlm.nih.gov/pubmed/?term=9328296 DMUY35B DI DMUY35B DMUY35B DN Progesterone DMUY35B MI DTUGYRD DMUY35B MN P-glycoprotein 1 (ABCB1) DMUY35B MT DTP DMUY35B MA Substrate DMUY35B RN Comparative studies on in vitro methods for evaluating in vivo function of MDR1 P-glycoprotein. Pharm Res. 2001 Dec;18(12):1660-8. DMUY35B RU http://www.ncbi.nlm.nih.gov/pubmed/11785684 DMUY35B DI DMUY35B DMUY35B DN Progesterone DMUY35B MI TTUV8G9 DMUY35B MN Progesterone receptor (PGR) DMUY35B MT DTT DMUY35B MA Agonist DMUY35B RN Clinical pipeline report, company report or official report of lipocine. DMUY35B RU http://www.lipocine.com/pipeline/lpcn-1107/ DMUY35B DI DMUY35B DMUY35B DN Progesterone DMUY35B MI DE0JMZ5 DMUY35B MN Steroid 21-hydroxylase (CYP21A2) DMUY35B MT DME DMUY35B MA Metabolism DMUY35B RN Human cytochrome P450 21A2, the major steroid 21-hydroxylase: structure of the enzyme progesterone substrate complex and rate-limiting C-H bond cleavage. J Biol Chem. 2015 May 22;290(21):13128-43. DMUY35B RU https://www.ncbi.nlm.nih.gov/pubmed/?term=25855791 DMUY35B DI DMUY35B DMUY35B DN Progesterone DMUY35B MI DEYWLRK DMUY35B MN Sulfotransferase 1A1 (SULT1A1) DMUY35B MT DME DMUY35B MA Metabolism DMUY35B RN Progestagenic effects of tibolone are target gene-specific in human endometrial cells. J Soc Gynecol Investig. 2006 Sep;13(6):459-65. DMUY35B RU https://www.ncbi.nlm.nih.gov/pubmed/?term=16879988 DMBL79I DI DMBL79I DMBL79I DN Proguanil DMBL79I MI DEJGDUW DMBL79I MN Cytochrome P450 1A2 (CYP1A2) DMBL79I MT DME DMBL79I MA Metabolism DMBL79I RN Comparison of (S)-mephenytoin and proguanil oxidation in vitro: contribution of several CYP isoforms. Br J Clin Pharmacol. 1999 Aug;48(2):158-67. DMBL79I RU https://www.ncbi.nlm.nih.gov/pubmed/?term=10417492 DMBL79I DI DMBL79I DMBL79I DN Proguanil DMBL79I MI DE5IED8 DMBL79I MN Cytochrome P450 2C9 (CYP2C9) DMBL79I MT DME DMBL79I MA Metabolism DMBL79I RN Summary of information on human CYP enzymes: human P450 metabolism data. Drug Metab Rev. 2002 Feb-May;34(1-2):83-448. DMBL79I RU https://www.ncbi.nlm.nih.gov/pubmed/?term=11996015 DMBL79I DI DMBL79I DMBL79I DN Proguanil DMBL79I MI DEVDYN7 DMBL79I MN Cytochrome P450 2E1 (CYP2E1) DMBL79I MT DME DMBL79I MA Metabolism DMBL79I RN Comparison of (S)-mephenytoin and proguanil oxidation in vitro: contribution of several CYP isoforms. Br J Clin Pharmacol. 1999 Aug;48(2):158-67. DMBL79I RU https://www.ncbi.nlm.nih.gov/pubmed/?term=10417492 DMBL79I DI DMBL79I DMBL79I DN Proguanil DMBL79I MI DE4LYSA DMBL79I MN Cytochrome P450 3A4 (CYP3A4) DMBL79I MT DME DMBL79I MA Metabolism DMBL79I RN In vitro proguanil activation to cycloguanil is mediated by CYP2C19 and CYP3A4 in adult Chinese liver microsomes. Acta Pharmacol Sin. 2000 Aug;21(8):747-52. DMBL79I RU https://www.ncbi.nlm.nih.gov/pubmed/?term=11501186 DMBL79I DI DMBL79I DMBL79I DN Proguanil DMBL79I MI DEGTFWK DMBL79I MN Mephenytoin 4-hydroxylase (CYP2C19) DMBL79I MT DME DMBL79I MA Metabolism DMBL79I RN Polymorphic oxidative metabolism of proguanil in a Nigerian population. Eur J Clin Pharmacol. 2002 Nov;58(8):543-5. DMBL79I RU https://www.ncbi.nlm.nih.gov/pubmed/?term=12451432 DMBL79I DI DMBL79I DMBL79I DN Proguanil DMBL79I MI TT9SL3Q DMBL79I MN Polypeptide deformylase (PDF) DMBL79I MT DTT DMBL79I MA Inhibitor DMBL79I RN Transformation with human dihydrofolate reductase renders malaria parasites insensitive to WR99210 but does not affect the intrinsic activity of proguanil. Proc Natl Acad Sci U S A. 1997 Sep 30;94(20):10931-6. DMBL79I RU https://pubmed.ncbi.nlm.nih.gov/9380737 DMYSCIL DI DMYSCIL DMYSCIL DN Prolastin DMYSCIL MI TTZBFA0 DMYSCIL MN Protease unspecific (PRO) DMYSCIL MT DTT DMYSCIL MA Inhibitor DMYSCIL RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015 DMYSCIL RU https://www.accessdata.fda.gov/scripts/cder/drugsatfda/ DMMJ1IS DI DMMJ1IS DMMJ1IS DN Prolixin decanoate DMMJ1IS MI TTK8CXU DMMJ1IS MN 5-HT 1B receptor (HTR1B) DMMJ1IS MT DTT DMMJ1IS MA Modulator DMMJ1IS RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. DMMJ1IS RU https://www.fda.gov/ DMMJ1IS DI DMMJ1IS DMMJ1IS DN Prolixin decanoate DMMJ1IS MI DECB0K3 DMMJ1IS MN Cytochrome P450 2D6 (CYP2D6) DMMJ1IS MT DME DMMJ1IS MA Metabolism DMMJ1IS RN Effect of antipsychotic drugs on human liver cytochrome P-450 (CYP) isoforms in vitro: preferential inhibition of CYP2D6. Drug Metab Dispos. 1999 Sep;27(9):1078-84. DMMJ1IS RU https://www.ncbi.nlm.nih.gov/pubmed/?term=10460810 DMZAL7W DI DMZAL7W DMZAL7W DN Promazine DMZAL7W MI DEJGDUW DMZAL7W MN Cytochrome P450 1A2 (CYP1A2) DMZAL7W MT DME DMZAL7W MA Metabolism DMZAL7W RN Contribution of human cytochrome p-450 isoforms to the metabolism of the simplest phenothiazine neuroleptic promazine. Br J Pharmacol. 2003 Apr;138(8):1465-74. DMZAL7W RU https://www.ncbi.nlm.nih.gov/pubmed/?term=12721102 DMZAL7W DI DMZAL7W DMZAL7W DN Promazine DMZAL7W MI DE5IED8 DMZAL7W MN Cytochrome P450 2C9 (CYP2C9) DMZAL7W MT DME DMZAL7W MA Metabolism DMZAL7W RN Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. DMZAL7W RU https://www.ncbi.nlm.nih.gov/pubmed/?term=19515014 DMZAL7W DI DMZAL7W DMZAL7W DN Promazine DMZAL7W MI DE4LYSA DMZAL7W MN Cytochrome P450 3A4 (CYP3A4) DMZAL7W MT DME DMZAL7W MA Metabolism DMZAL7W RN Contribution of human cytochrome p-450 isoforms to the metabolism of the simplest phenothiazine neuroleptic promazine. Br J Pharmacol. 2003 Apr;138(8):1465-74. DMZAL7W RU https://www.ncbi.nlm.nih.gov/pubmed/?term=12721102 DMZAL7W DI DMZAL7W DMZAL7W DN Promazine DMZAL7W MI DEGTFWK DMZAL7W MN Mephenytoin 4-hydroxylase (CYP2C19) DMZAL7W MT DME DMZAL7W MA Metabolism DMZAL7W RN Contribution of human cytochrome p-450 isoforms to the metabolism of the simplest phenothiazine neuroleptic promazine. Br J Pharmacol. 2003 Apr;138(8):1465-74. DMZAL7W RU https://www.ncbi.nlm.nih.gov/pubmed/?term=12721102 DMZAL7W DI DMZAL7W DMZAL7W DN Promazine DMZAL7W MI TTH18TF DMZAL7W MN Muscarinic acetylcholine receptor M5 (CHRM5) DMZAL7W MT DTT DMZAL7W MA Binder DMZAL7W RN Muscarinic cholinergic and histamine H1 receptor binding of phenothiazine drug metabolites. Life Sci. 1988;43(5):405-12. DMZAL7W RU https://pubmed.ncbi.nlm.nih.gov/2899826 DMK4S8I DI DMK4S8I DMK4S8I DN Promegestone DMK4S8I MI DE4LYSA DMK4S8I MN Cytochrome P450 3A4 (CYP3A4) DMK4S8I MT DME DMK4S8I MA Metabolism DMK4S8I RN Progestogens in menopausal hormone therapy. Prz Menopauzalny. 2015 Jun;14(2):134-43. DMK4S8I RU https://www.ncbi.nlm.nih.gov/pubmed/?term=26327902 DMU92F8 DI DMU92F8 DMU92F8 DN Promestriene DMU92F8 MI TTZAYWL DMU92F8 MN Estrogen receptor (ESR) DMU92F8 MT DTT DMU92F8 MA Modulator DMU92F8 RN Promestriene, a specific topic estrogen. Review of 40 years of vaginal atrophy treatment: is it safe even in cancer patients. Anticancer Drugs. 2013 Nov;24(10):989-98. DMU92F8 RU https://pubmed.ncbi.nlm.nih.gov/24080714 DM6I5GR DI DM6I5GR DM6I5GR DN Promethazine DM6I5GR MI DEPKLMQ DM6I5GR MN Cytochrome P450 2B6 (CYP2B6) DM6I5GR MT DME DM6I5GR MA Metabolism DM6I5GR RN Bupropion and 4-OH-bupropion pharmacokinetics in relation to genetic polymorphisms in CYP2B6. Pharmacogenetics. 2003 Oct;13(10):619-26. DM6I5GR RU https://www.ncbi.nlm.nih.gov/pubmed/?term=14515060 DM6I5GR DI DM6I5GR DM6I5GR DN Promethazine DM6I5GR MI DECB0K3 DM6I5GR MN Cytochrome P450 2D6 (CYP2D6) DM6I5GR MT DME DM6I5GR MA Metabolism DM6I5GR RN Akathisia with combined use of midodrine and promethazine. JAMA. 2006 May 3;295(17):2000-1. Letter DM6I5GR RU https://www.ncbi.nlm.nih.gov/pubmed/?term=16670408 DM6I5GR DI DM6I5GR DM6I5GR DN Promethazine DM6I5GR MI TTTIBOJ DM6I5GR MN Histamine H1 receptor (H1R) DM6I5GR MT DTT DM6I5GR MA Antagonist DM6I5GR RN Intact cell binding for in vitro prediction of sedative and non-sedative histamine H1-receptor antagonists based on receptor internalization. J Pharmacol Sci. 2008 May;107(1):66-79. DM6I5GR RU https://pubmed.ncbi.nlm.nih.gov/18446005 DMPIBJK DI DMPIBJK DMPIBJK DN Propafenone DMPIBJK MI DEJGDUW DMPIBJK MN Cytochrome P450 1A2 (CYP1A2) DMPIBJK MT DME DMPIBJK MA Metabolism DMPIBJK RN Inhibitory effects of antiarrhythmic drugs on phenacetin O-deethylation catalysed by human CYP1A2. Br J Clin Pharmacol. 1998 Apr;45(4):361-8. DMPIBJK RU https://www.ncbi.nlm.nih.gov/pubmed/?term=9578183 DMPIBJK DI DMPIBJK DMPIBJK DN Propafenone DMPIBJK MI DECB0K3 DMPIBJK MN Cytochrome P450 2D6 (CYP2D6) DMPIBJK MT DME DMPIBJK MA Metabolism DMPIBJK RN Effect of selective serotonin reuptake inhibitors on the oxidative metabolism of propafenone: in vitro studies using human liver microsomes. J Clin Psychopharmacol. 2000 Aug;20(4):428-34. DMPIBJK RU https://www.ncbi.nlm.nih.gov/pubmed/?term=10917404 DMPIBJK DI DMPIBJK DMPIBJK DN Propafenone DMPIBJK MI DE4LYSA DMPIBJK MN Cytochrome P450 3A4 (CYP3A4) DMPIBJK MT DME DMPIBJK MA Metabolism DMPIBJK RN Effect of selective serotonin reuptake inhibitors on the oxidative metabolism of propafenone: in vitro studies using human liver microsomes. J Clin Psychopharmacol. 2000 Aug;20(4):428-34. DMPIBJK RU https://www.ncbi.nlm.nih.gov/pubmed/?term=10917404 DMPIBJK DI DMPIBJK DMPIBJK DN Propafenone DMPIBJK MI TT05DLS DMPIBJK MN E3 ubiquitin-protein ligase COP1 (RFWD2) DMPIBJK MT DTT DMPIBJK MA Modulator DMPIBJK RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. DMPIBJK RU https://www.fda.gov/ DMPIBJK DI DMPIBJK DMPIBJK DN Propafenone DMPIBJK MI DTUGYRD DMPIBJK MN P-glycoprotein 1 (ABCB1) DMPIBJK MT DTP DMPIBJK MA Substrate DMPIBJK RN Mammalian drug efflux transporters of the ATP binding cassette (ABC) family in multidrug resistance: A review of the past decade. Cancer Lett. 2016 Jan 1;370(1):153-64. DMPIBJK RU http://www.ncbi.nlm.nih.gov/pubmed/26499806 DM2EN6G DI DM2EN6G DM2EN6G DN Propantheline DM2EN6G MI TTZ9SOR DM2EN6G MN Muscarinic acetylcholine receptor M1 (CHRM1) DM2EN6G MT DTT DM2EN6G MA Antagonist DM2EN6G RN Involvement of the peripheral cholinergic muscarinic system in the compensatory ovarian hypertrophy in the rat. Exp Biol Med (Maywood). 2004 Sep;229(8):793-805. DM2EN6G RU https://pubmed.ncbi.nlm.nih.gov/15337834 DMLS39E DI DMLS39E DMLS39E DN Proparacaine DMLS39E MI TT90XZ8 DMLS39E MN Voltage-gated sodium channel alpha Nav1.8 (SCN10A) DMLS39E MT DTT DMLS39E MA Modulator DMLS39E RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. DMLS39E RU https://www.fda.gov/ DM6JQ2I DI DM6JQ2I DM6JQ2I DN Propentofylline propionate DM6JQ2I MI DEJGDUW DM6JQ2I MN Cytochrome P450 1A2 (CYP1A2) DM6JQ2I MT DME DM6JQ2I MA Metabolism DM6JQ2I RN PharmGKB summary: caffeine pathway. Pharmacogenet Genomics. 2012 May;22(5):389-95. DM6JQ2I RU https://www.ncbi.nlm.nih.gov/pubmed/?term=22293536 DME9JNL DI DME9JNL DME9JNL DN Propericiazine DME9JNL MI TTBRKXS DME9JNL MN Adrenergic receptor alpha-1B (ADRA1B) DME9JNL MT DTT DME9JNL MA Binder DME9JNL RN Interaction of neuroleptics and antidepressants with rat brain alpha 2-receptors: a possible relationship between alpha 2-receptor antagonism and antidepressant action. Biol Psychiatry. 1984 Sep;19(9):1283-91. DME9JNL RU https://pubmed.ncbi.nlm.nih.gov/6149771 DMWDHUZ DI DMWDHUZ DMWDHUZ DN Propicillin DMWDHUZ MI DTLT3UG DMWDHUZ MN Monocarboxylate transporter 2 (SLC16A7) DMWDHUZ MT DTP DMWDHUZ MA Substrate DMWDHUZ RN Monocarboxylate Transporters in Drug Disposition: Role in the Toxicokinetics and Toxicodynamics of the Drug of Abuse GHB. DMWDHUZ RU https://www.njacs.org/wp-content/docs/2010-Spring-DrugMet-Marilyn_Morris.pdf DMKY8V1 DI DMKY8V1 DMKY8V1 DN Propiomazine DMKY8V1 MI TTTIBOJ DMKY8V1 MN Histamine H1 receptor (H1R) DMKY8V1 MT DTT DMKY8V1 MA Antagonist DMKY8V1 RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMKY8V1 RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMUWBIJ DI DMUWBIJ DMUWBIJ DN Propiverine DMUWBIJ MI DE4LYSA DMUWBIJ MN Cytochrome P450 3A4 (CYP3A4) DMUWBIJ MT DME DMUWBIJ MA Metabolism DMUWBIJ RN Product monograph: Mictoryl (Propiverine hydrochloride modified-release capsules). DMUWBIJ RU https://www.duchesnay.com/files/pdf/mictoryl-monograph.pdf DMUWBIJ DI DMUWBIJ DMUWBIJ DN Propiverine DMUWBIJ MI TTH18TF DMUWBIJ MN Muscarinic acetylcholine receptor M5 (CHRM5) DMUWBIJ MT DTT DMUWBIJ MA Antagonist DMUWBIJ RN Affinity profiles of various muscarinic antagonists for cloned human muscarinic acetylcholine receptor (mAChR) subtypes and mAChRs in rat heart and submandibular gland. Life Sci. 1999;64(25):2351-8. DMUWBIJ RU https://pubmed.ncbi.nlm.nih.gov/10374898 DMB4OLE DI DMB4OLE DMB4OLE DN Propofol DMB4OLE MI DEJGDUW DMB4OLE MN Cytochrome P450 1A2 (CYP1A2) DMB4OLE MT DME DMB4OLE MA Metabolism DMB4OLE RN Inhibition of cytochrome P450 2E1 by propofol in human and porcine liver microsomes. Biochem Pharmacol. 2002 Oct 1;64(7):1151-6. DMB4OLE RU https://www.ncbi.nlm.nih.gov/pubmed/?term=12234619 DMB4OLE DI DMB4OLE DMB4OLE DN Propofol DMB4OLE MI DEJVYAZ DMB4OLE MN Cytochrome P450 2A6 (CYP2A6) DMB4OLE MT DME DMB4OLE MA Metabolism DMB4OLE RN Possible involvement of multiple human cytochrome P450 isoforms in the liver metabolism of propofol. Br J Anaesth. 1998 Jun;80(6):788-95. DMB4OLE RU https://www.ncbi.nlm.nih.gov/pubmed/?term=9771309 DMB4OLE DI DMB4OLE DMB4OLE DN Propofol DMB4OLE MI DEPKLMQ DMB4OLE MN Cytochrome P450 2B6 (CYP2B6) DMB4OLE MT DME DMB4OLE MA Metabolism DMB4OLE RN Involvement of human cytochrome P450 2B6 in the omega- and 4-hydroxylation of the anesthetic agent propofol. Xenobiotica. 2007 Jul;37(7):717-24. DMB4OLE RU https://www.ncbi.nlm.nih.gov/pubmed/?term=17620218 DMB4OLE DI DMB4OLE DMB4OLE DN Propofol DMB4OLE MI DEZMWRE DMB4OLE MN Cytochrome P450 2C18 (CYP2C18) DMB4OLE MT DME DMB4OLE MA Metabolism DMB4OLE RN Possible involvement of multiple human cytochrome P450 isoforms in the liver metabolism of propofol. Br J Anaesth. 1998 Jun;80(6):788-95. DMB4OLE RU https://www.ncbi.nlm.nih.gov/pubmed/?term=9771309 DMB4OLE DI DMB4OLE DMB4OLE DN Propofol DMB4OLE MI DES5XRU DMB4OLE MN Cytochrome P450 2C8 (CYP2C8) DMB4OLE MT DME DMB4OLE MA Metabolism DMB4OLE RN Possible involvement of multiple human cytochrome P450 isoforms in the liver metabolism of propofol. Br J Anaesth. 1998 Jun;80(6):788-95. DMB4OLE RU https://www.ncbi.nlm.nih.gov/pubmed/?term=9771309 DMB4OLE DI DMB4OLE DMB4OLE DN Propofol DMB4OLE MI DE5IED8 DMB4OLE MN Cytochrome P450 2C9 (CYP2C9) DMB4OLE MT DME DMB4OLE MA Metabolism DMB4OLE RN Cytochrome P-450 2B6 is responsible for interindividual variability of propofol hydroxylation by human liver microsomes. Anesthesiology. 2001 Jan;94(1):110-9. DMB4OLE RU https://www.ncbi.nlm.nih.gov/pubmed/?term=11135730 DMB4OLE DI DMB4OLE DMB4OLE DN Propofol DMB4OLE MI DECB0K3 DMB4OLE MN Cytochrome P450 2D6 (CYP2D6) DMB4OLE MT DME DMB4OLE MA Metabolism DMB4OLE RN Effects of propofol on human hepatic microsomal cytochrome P450 activities. Xenobiotica. 1998 Sep;28(9):845-53. DMB4OLE RU https://www.ncbi.nlm.nih.gov/pubmed/?term=9764927 DMB4OLE DI DMB4OLE DMB4OLE DN Propofol DMB4OLE MI DEVDYN7 DMB4OLE MN Cytochrome P450 2E1 (CYP2E1) DMB4OLE MT DME DMB4OLE MA Metabolism DMB4OLE RN Inhibition of cytochrome P450 2E1 by propofol in human and porcine liver microsomes. Biochem Pharmacol. 2002 Oct 1;64(7):1151-6. DMB4OLE RU https://www.ncbi.nlm.nih.gov/pubmed/?term=12234619 DMB4OLE DI DMB4OLE DMB4OLE DN Propofol DMB4OLE MI DE4LYSA DMB4OLE MN Cytochrome P450 3A4 (CYP3A4) DMB4OLE MT DME DMB4OLE MA Metabolism DMB4OLE RN Cytochrome P-450 2B6 is responsible for interindividual variability of propofol hydroxylation by human liver microsomes. Anesthesiology. 2001 Jan;94(1):110-9. DMB4OLE RU https://www.ncbi.nlm.nih.gov/pubmed/?term=11135730 DMB4OLE DI DMB4OLE DMB4OLE DN Propofol DMB4OLE MI TTDP1UC DMB4OLE MN Fatty acid amide hydrolase (FAAH) DMB4OLE MT DTT DMB4OLE MA Inhibitor DMB4OLE RN Glutamate- and GABA-based CNS therapeutics. Curr Opin Pharmacol. 2006 Feb;6(1):7-17. DMB4OLE RU https://pubmed.ncbi.nlm.nih.gov/16377242 DMB4OLE DI DMB4OLE DMB4OLE DN Propofol DMB4OLE MI DEGTFWK DMB4OLE MN Mephenytoin 4-hydroxylase (CYP2C19) DMB4OLE MT DME DMB4OLE MA Metabolism DMB4OLE RN Possible involvement of multiple human cytochrome P450 isoforms in the liver metabolism of propofol. Br J Anaesth. 1998 Jun;80(6):788-95. DMB4OLE RU https://www.ncbi.nlm.nih.gov/pubmed/?term=9771309 DMB4OLE DI DMB4OLE DMB4OLE DN Propofol DMB4OLE MI DEUM1EX DMB4OLE MN Oleamide hydrolase 1 (FAAH) DMB4OLE MT DME DMB4OLE MA Metabolism DMB4OLE RN Update of TTD: therapeutic target database. Nucleic Acids Res. 2010 Jan;38(Database issue):D787-91. DMB4OLE RU https://www.ncbi.nlm.nih.gov/pubmed/?term=19933260 DMB4OLE DI DMB4OLE DMB4OLE DN Propofol DMB4OLE MI DEYGVN4 DMB4OLE MN UDP-glucuronosyltransferase 1A1 (UGT1A1) DMB4OLE MT DME DMB4OLE MA Metabolism DMB4OLE RN Substrate-dependent modulation of UDP-glucuronosyltransferase 1A1 (UGT1A1) by propofol in recombinant human UGT1A1 and human liver microsomes. Basic Clin Pharmacol Toxicol. 2007 Sep;101(3):211-4. DMB4OLE RU https://www.ncbi.nlm.nih.gov/pubmed/?term=17697043 DMB4OLE DI DMB4OLE DMB4OLE DN Propofol DMB4OLE MI DESD26P DMB4OLE MN UDP-glucuronosyltransferase 1A6 (UGT1A6) DMB4OLE MT DME DMB4OLE MA Metabolism DMB4OLE RN Pharmacokinetics of propofol and extrahepatic UGT1A6 gene expression in anhepatic rats. Pharmacology. 2009;84(4):219-26. DMB4OLE RU https://www.ncbi.nlm.nih.gov/pubmed/?term=19752585 DMB4OLE DI DMB4OLE DMB4OLE DN Propofol DMB4OLE MI DE85D2P DMB4OLE MN UDP-glucuronosyltransferase 1A9 (UGT1A9) DMB4OLE MT DME DMB4OLE MA Metabolism DMB4OLE RN Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. DMB4OLE RU https://www.ncbi.nlm.nih.gov/pubmed/?term=19515014 DMMSOLA DI DMMSOLA DMMSOLA DN Propoxyphene Hydrochloride DMMSOLA MI TTKWM86 DMMSOLA MN Opioid receptor mu (MOP) DMMSOLA MT DTT DMMSOLA MA Modulator DMMSOLA RN Norpropoxyphene-induced cardiotoxicity is associated with changes in ion-selectivity and gating of HERG currents. Cardiovasc Res. 1999 Dec;44(3):568-78. DMMSOLA RU https://www.ncbi.nlm.nih.gov/pubmed/10690289 DM79NTF DI DM79NTF DM79NTF DN Propranolol DM79NTF MI TTR6W5O DM79NTF MN Adrenergic receptor beta-1 (ADRB1) DM79NTF MT DTT DM79NTF MA Antagonist DM79NTF RN Beta-blockers in the treatment of hypertension: are there clinically relevant differences Postgrad Med. 2009 May;121(3):90-8. DM79NTF RU https://pubmed.ncbi.nlm.nih.gov/19491545 DM79NTF DI DM79NTF DM79NTF DN Propranolol DM79NTF MI DE4OGUF DM79NTF MN Cytochrome P450 102A1 (cyp102) DM79NTF MT DME DM79NTF MA Metabolism DM79NTF RN acillus megaterium SF185 spores exert protective effects against oxidative stress in vivo and in vitro. Sci Rep. 2019 Aug 19;9(1):12082. DM79NTF RU https://pubmed.ncbi.nlm.nih.gov/31427655 DM79NTF DI DM79NTF DM79NTF DN Propranolol DM79NTF MI DEJGDUW DM79NTF MN Cytochrome P450 1A2 (CYP1A2) DM79NTF MT DME DM79NTF MA Metabolism DM79NTF RN Synthetic and natural compounds that interact with human cytochrome P450 1A2 and implications in drug development. Curr Med Chem. 2009;16(31):4066-218. DM79NTF RU https://www.ncbi.nlm.nih.gov/pubmed/?term=19754423 DM79NTF DI DM79NTF DM79NTF DN Propranolol DM79NTF MI DECB0K3 DM79NTF MN Cytochrome P450 2D6 (CYP2D6) DM79NTF MT DME DM79NTF MA Metabolism DM79NTF RN Structure-activity relationship for human cytochrome P450 substrates and inhibitors. Drug Metab Rev. 2002 Feb-May;34(1-2):69-82. DM79NTF RU https://www.ncbi.nlm.nih.gov/pubmed/?term=11996013 DM79NTF DI DM79NTF DM79NTF DN Propranolol DM79NTF MI DE4LYSA DM79NTF MN Cytochrome P450 3A4 (CYP3A4) DM79NTF MT DME DM79NTF MA Metabolism DM79NTF RN Cytochrome P450 isozymes involved in propranolol metabolism in human liver microsomes. The role of CYP2D6 as ring-hydroxylase and CYP1A2 as N-desisopropylase. Drug Metab Dispos. 1994 Nov-Dec;22(6):909-15. DM79NTF RU https://www.ncbi.nlm.nih.gov/pubmed/?term=7895609 DM79NTF DI DM79NTF DM79NTF DN Propranolol DM79NTF MI DEIBDNY DM79NTF MN Cytochrome P450 3A5 (CYP3A5) DM79NTF MT DME DM79NTF MA Metabolism DM79NTF RN The influence of diltiazem versus cimetidine on propranolol metabolism. J Clin Pharmacol. 1992 Dec;32(12):1099-104. DM79NTF RU https://www.ncbi.nlm.nih.gov/pubmed/?term=1487547 DM79NTF DI DM79NTF DM79NTF DN Propranolol DM79NTF MI DERD86B DM79NTF MN Cytochrome P450 3A7 (CYP3A7) DM79NTF MT DME DM79NTF MA Metabolism DM79NTF RN The influence of diltiazem versus cimetidine on propranolol metabolism. J Clin Pharmacol. 1992 Dec;32(12):1099-104. DM79NTF RU https://www.ncbi.nlm.nih.gov/pubmed/?term=1487547 DM79NTF DI DM79NTF DM79NTF DN Propranolol DM79NTF MI DEIASEZ DM79NTF MN Dimethylaniline oxidase 2 (FMO2) DM79NTF MT DME DM79NTF MA Metabolism DM79NTF RN Human FMO2-based microbial whole-cell catalysts for drug metabolite synthesis. Microb Cell Fact. 2015 Jun 12;14:82. DM79NTF RU https://www.ncbi.nlm.nih.gov/pubmed/?term=26062974 DM79NTF DI DM79NTF DM79NTF DN Propranolol DM79NTF MI DEGTFWK DM79NTF MN Mephenytoin 4-hydroxylase (CYP2C19) DM79NTF MT DME DM79NTF MA Metabolism DM79NTF RN Clinical relevance of genetic polymorphisms in the human CYP2C subfamily. Br J Clin Pharmacol. 2001 Oct;52(4):349-55. DM79NTF RU https://www.ncbi.nlm.nih.gov/pubmed/?term=11678778 DM79NTF DI DM79NTF DM79NTF DN Propranolol DM79NTF MI DTT79CX DM79NTF MN Organic cation transporter 1 (SLC22A1) DM79NTF MT DTP DM79NTF MA Substrate DM79NTF RN Influx Transport of Cationic Drug at the Blood-Retinal Barrier: Impact on the Retinal Delivery of Neuroprotectants. Biol Pharm Bull. 2017;40(8):1139-1145. DM79NTF RU http://www.ncbi.nlm.nih.gov/pubmed/28768994 DM79NTF DI DM79NTF DM79NTF DN Propranolol DM79NTF MI DT9IDPW DM79NTF MN Organic cation transporter 2 (SLC22A2) DM79NTF MT DTP DM79NTF MA Substrate DM79NTF RN Influx Transport of Cationic Drug at the Blood-Retinal Barrier: Impact on the Retinal Delivery of Neuroprotectants. Biol Pharm Bull. 2017;40(8):1139-1145. DM79NTF RU http://www.ncbi.nlm.nih.gov/pubmed/28768994 DM79NTF DI DM79NTF DM79NTF DN Propranolol DM79NTF MI DT6201N DM79NTF MN Organic cation transporter 3 (SLC22A3) DM79NTF MT DTP DM79NTF MA Substrate DM79NTF RN Influx Transport of Cationic Drug at the Blood-Retinal Barrier: Impact on the Retinal Delivery of Neuroprotectants. Biol Pharm Bull. 2017;40(8):1139-1145. DM79NTF RU http://www.ncbi.nlm.nih.gov/pubmed/28768994 DM79NTF DI DM79NTF DM79NTF DN Propranolol DM79NTF MI DTUGYRD DM79NTF MN P-glycoprotein 1 (ABCB1) DM79NTF MT DTP DM79NTF MA Substrate DM79NTF RN Tarascon Pocket Pharmacopoeia 2018 Classic Shirt-Pocket Edition. DM79NTF RU https://books.google.com/books?id=0gBRDwAAQBAJ&pg=PP37&lpg=PP37&dq=Methylergonovine+transporter+uptake+efflex&source=bl&ots=cUTe_ppsmZ&sig=ACfU3U3E_YqrDg0CNEuj8K-7lci47HAnrg&hl=zh-CN&sa=X&ved=2ahUKEwjnj-Dk7d7iAhUsK6YKHd5DBDkQ6AEwEnoECAgQAQ#v=onepage&q&f=false DMTBW2O DI DMTBW2O DMTBW2O DN Propylhexedrine DMTBW2O MI TT2NUT5 DMTBW2O MN Adrenergic receptor alpha-2C (ADRA2C) DMTBW2O MT DTT DMTBW2O MA Modulator DMTBW2O RN Airway compromise and delayed death following attempted central vein injection of propylhexedrine. J Emerg Med. 1994 Nov-Dec;12(6):795-7. DMTBW2O RU https://pubmed.ncbi.nlm.nih.gov/7533806 DM6D7N8 DI DM6D7N8 DM6D7N8 DN Propylthiouracil DM6D7N8 MI TTU3X26 DM6D7N8 MN Iodothyronine deiodinase type I (DIO1) DM6D7N8 MT DTT DM6D7N8 MA Inhibitor DM6D7N8 RN Type 1 iodothyronine deiodinase is the major source of circulating T3 in hyperthyroidism: implications for therapy. Nat Clin Pract Endocrinol Metab. 2007 Nov;3(11):740-1. DM6D7N8 RU https://pubmed.ncbi.nlm.nih.gov/17712320 DM6D7N8 DI DM6D7N8 DM6D7N8 DN Propylthiouracil DM6D7N8 MI TT52XDZ DM6D7N8 MN Thyroid peroxidase (TPO) DM6D7N8 MT DTT DM6D7N8 MA Inhibitor DM6D7N8 RN Bioinorganic chemistry in thyroid gland: effect of antithyroid drugs on peroxidase-catalyzed oxidation and iodination reactions. Bioinorg Chem Appl. 2006:23214. DM6D7N8 RU https://pubmed.ncbi.nlm.nih.gov/17497002 DMX0EZJ DI DMX0EZJ DMX0EZJ DN Prothionamide DMX0EZJ MI TTVTX4N DMX0EZJ MN Bacterial Fatty acid synthetase I (Bact inhA) DMX0EZJ MT DTT DMX0EZJ MA Inhibitor DMX0EZJ RN Mechanism of thioamide drug action against tuberculosis and leprosy. J Exp Med. 2007 Jan 22;204(1):73-8. DMX0EZJ RU https://pubmed.ncbi.nlm.nih.gov/17227913 DMGN5QD DI DMGN5QD DMGN5QD DN Protirelin DMGN5QD MI DEVDR46 DMGN5QD MN Pyrrolidone-carboxylate peptidase (PGPI) DMGN5QD MT DME DMGN5QD MA Metabolism DMGN5QD RN Marginal involvement of pyroglutamyl aminopeptidase I in metabolism of thyrotropin-releasing hormone in rat brain. Biol Pharm Bull. 2004 Aug;27(8):1197-201. DMGN5QD RU https://www.ncbi.nlm.nih.gov/pubmed/?term=15305021 DMGN5QD DI DMGN5QD DMGN5QD DN Protirelin DMGN5QD MI TT4J8MF DMGN5QD MN Thyrotropin-releasing hormone receptor (TRHR) DMGN5QD MT DTT DMGN5QD MA Modulator DMGN5QD RN Company report (takeda) DMGN5QD RU https://www.takeda.com/csr/reports/pdf/index/ar2010_04_en.pdf DMAHZKR DI DMAHZKR DMAHZKR DN Protokylol Hydrochloride DMAHZKR MI TTR6W5O DMAHZKR MN Adrenergic receptor beta-1 (ADRB1) DMAHZKR MT DTT DMAHZKR MA Modulator DMAHZKR RN N-Aralkyl substitution increases the affinity of adrenergic drugs for the alpha-adrenoceptor in rat liver. DMAHZKR RU https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1668481 DMNHTZI DI DMNHTZI DMNHTZI DN Protriptyline DMNHTZI MI TTAWNKZ DMNHTZI MN Norepinephrine transporter (NET) DMNHTZI MT DTT DMNHTZI MA Inhibitor DMNHTZI RN Analgesic properties of intrathecally administered heterocyclic antidepressants. Pain. 1987 Mar;28(3):343-55. DMNHTZI RU https://pubmed.ncbi.nlm.nih.gov/3494977 DMNHTZI DI DMNHTZI DMNHTZI DN Protriptyline DMNHTZI MI DTUGYRD DMNHTZI MN P-glycoprotein 1 (ABCB1) DMNHTZI MT DTP DMNHTZI MA Substrate DMNHTZI RN Passive permeability and P-glycoprotein-mediated efflux differentiate central nervous system (CNS) and non-CNS marketed drugs. J Pharmacol Exp Ther. 2002 Dec;303(3):1029-37. DMNHTZI RU http://www.ncbi.nlm.nih.gov/pubmed/12438524 DMGKT2L DI DMGKT2L DMGKT2L DN Pro-urokinase DMGKT2L MI TTGY7WI DMGKT2L MN Urokinase-type plasminogen activator (PLAU) DMGKT2L MT DTT DMGKT2L MA Modulator DMGKT2L RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2393). DMGKT2L RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2393 DMOK965 DI DMOK965 DMOK965 DN Prulifloxacin DMOK965 MI TTN6J5F DMOK965 MN Bacterial DNA gyrase (Bact gyrase) DMOK965 MT DTT DMOK965 MA Inhibitor DMOK965 RN Prulifloxacin: a new antibacterial fluoroquinolone. Expert Rev Anti Infect Ther. 2006 Feb;4(1):27-41. DMOK965 RU https://pubmed.ncbi.nlm.nih.gov/16441207 DMOK965 DI DMOK965 DMOK965 DN Prulifloxacin DMOK965 MI TTFK8YB DMOK965 MN Bacterial DNA topoisomerase 4A (Bact parC) DMOK965 MT DTT DMOK965 MA Inhibitor DMOK965 RN Prulifloxacin: a new antibacterial fluoroquinolone. Expert Rev Anti Infect Ther. 2006 Feb;4(1):27-41. DMOK965 RU https://pubmed.ncbi.nlm.nih.gov/16441207 DMIVJ0D DI DMIVJ0D DMIVJ0D DN Pseudoephedrine DMIVJ0D MI TTEX248 DMIVJ0D MN Dopamine D2 receptor (D2R) DMIVJ0D MT DTT DMIVJ0D MA Stimulator DMIVJ0D RN Cetirizine/pseudoephedrine. Drugs. 2001;61(15):2231-40; discussion 2241-2. DMIVJ0D RU https://pubmed.ncbi.nlm.nih.gov/11772135 DMIVJ0D DI DMIVJ0D DMIVJ0D DN Pseudoephedrine DMIVJ0D MI DEYWLRK DMIVJ0D MN Sulfotransferase 1A1 (SULT1A1) DMIVJ0D MT DME DMIVJ0D MA Metabolism DMIVJ0D RN Benzylic alcohols as stereospecific substrates and inhibitors for aryl sulfotransferase. Chirality. 1991;3(2):104-11. DMIVJ0D RU https://www.ncbi.nlm.nih.gov/pubmed/?term=1863522 DMLSUWZ DI DMLSUWZ DMLSUWZ DN PSI-7977 DMLSUWZ MI DEWJATF DMLSUWZ MN Adenosine 5'-monophosphoramidase (HINT1) DMLSUWZ MT DME DMLSUWZ MA Metabolism DMLSUWZ RN Mechanism of activation of PSI-7851 and its diastereoisomer PSI-7977. J Biol Chem. 2010 Nov 5;285(45):34337-47. DMLSUWZ RU https://www.ncbi.nlm.nih.gov/pubmed/?term=20801890 DMLSUWZ DI DMLSUWZ DMLSUWZ DN PSI-7977 DMLSUWZ MI DEB30C5 DMLSUWZ MN Carboxylesterase 1 (CES1) DMLSUWZ MT DME DMLSUWZ MA Metabolism DMLSUWZ RN Mechanism of activation of PSI-7851 and its diastereoisomer PSI-7977. J Biol Chem. 2010 Nov 5;285(45):34337-47. DMLSUWZ RU https://www.ncbi.nlm.nih.gov/pubmed/?term=20801890 DMLSUWZ DI DMLSUWZ DMLSUWZ DN PSI-7977 DMLSUWZ MI TTMVBWH DMLSUWZ MN Hepatitis C virus RNA-directed RNA polymerase (HCV NS5B) DMLSUWZ MT DTT DMLSUWZ MA Modulator DMLSUWZ RN Radium 223 dichloride for prostate cancer treatment. Drug Des Devel Ther. 2017 Sep 6;11:2643-2651. DMLSUWZ RU https://pubmed.ncbi.nlm.nih.gov/28919714 DMWLTU2 DI DMWLTU2 DMWLTU2 DN PSMA-11 Ga-68 DMWLTU2 MI TT9G4N0 DMWLTU2 MN Glutamate carboxypeptidase II (GCPII) DMWLTU2 MT DTT DMWLTU2 MA Binder DMWLTU2 RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health Human Services. 2020 DMWLTU2 RU https://www.accessdata.fda.gov/drugsatfda_docs/label/2020/212642s000lbl.pdf DMG2X3E DI DMG2X3E DMG2X3E DN Pyrantel DMG2X3E MI DECB0K3 DMG2X3E MN Cytochrome P450 2D6 (CYP2D6) DMG2X3E MT DME DMG2X3E MA Metabolism DMG2X3E RN Identification of human cytochrome P(450)s that metabolise anti-parasitic drugs and predictions of in vivo drug hepatic clearance from in vitro data. Eur J Clin Pharmacol. 2003 Sep;59(5-6):429-42. DMG2X3E RU https://www.ncbi.nlm.nih.gov/pubmed/?term=12920490 DM4IF32 DI DM4IF32 DM4IF32 DN Pyrazinamide DM4IF32 MI TTVTX4N DM4IF32 MN Bacterial Fatty acid synthetase I (Bact inhA) DM4IF32 MT DTT DM4IF32 MA Inhibitor DM4IF32 RN Pyrazinamide inhibits the eukaryotic-like fatty acid synthetase I (FASI) of Mycobacterium tuberculosis. Nat Med. 2000 Sep;6(9):1043-7. DM4IF32 RU https://pubmed.ncbi.nlm.nih.gov/10973326 DM4IF32 DI DM4IF32 DM4IF32 DN Pyrazinamide DM4IF32 MI DEJGDUW DM4IF32 MN Cytochrome P450 1A2 (CYP1A2) DM4IF32 MT DME DM4IF32 MA Metabolism DM4IF32 RN The metabolism of pyrazoloacridine (NSC 366140) by cytochromes p450 and flavin monooxygenase in human liver microsomes. Clin Cancer Res. 2004 Feb 15;10(4):1471-80. DM4IF32 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=14977851 DM4IF32 DI DM4IF32 DM4IF32 DN Pyrazinamide DM4IF32 MI DE4LYSA DM4IF32 MN Cytochrome P450 3A4 (CYP3A4) DM4IF32 MT DME DM4IF32 MA Metabolism DM4IF32 RN The metabolism of pyrazoloacridine (NSC 366140) by cytochromes p450 and flavin monooxygenase in human liver microsomes. Clin Cancer Res. 2004 Feb 15;10(4):1471-80. DM4IF32 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=14977851 DM4IF32 DI DM4IF32 DM4IF32 DN Pyrazinamide DM4IF32 MI DERQS6E DM4IF32 MN Nicotinamidase (pncA) DM4IF32 MT DME DM4IF32 MA Metabolism DM4IF32 RN Specificity and mechanism of Acinetobacter baumanii nicotinamidase: implications for activation of the front-line tuberculosis drug pyrazinamide. Angew Chem Int Ed Engl. 2009;48(48):9176-9. DM4IF32 RU https://pubmed.ncbi.nlm.nih.gov/19859929 DM8HO1L DI DM8HO1L DM8HO1L DN Pyridostigmine DM8HO1L MI TT1RS9F DM8HO1L MN Acetylcholinesterase (AChE) DM8HO1L MT DTT DM8HO1L MA Inhibitor DM8HO1L RN Neuromuscular blockade, reversal agent use, and operating room time: retrospective analysis of US inpatient surgeries. Curr Med Res Opin. 2009 Apr;25(4):943-50. DM8HO1L RU https://pubmed.ncbi.nlm.nih.gov/19257799 DMO2K0J DI DMO2K0J DMO2K0J DN Pyridoxal Phosphate DMO2K0J MI TT6L509 DMO2K0J MN Coagulation factor IIa (F2) DMO2K0J MT DTT DMO2K0J MA Inhibitor DMO2K0J RN New antithrombotic drugs (excluding plasminogen activators. Arch Mal Coeur Vaiss. 2001 Nov;94(11 Suppl):1225-32. DMO2K0J RU https://pubmed.ncbi.nlm.nih.gov/11794963 DMO2K0J DI DMO2K0J DMO2K0J DN Pyridoxal Phosphate DMO2K0J MI TTT2LD9 DMO2K0J MN GABA transaminase (ABAT) DMO2K0J MT DTT DMO2K0J MA Inhibitor DMO2K0J RN DrugBank: a knowledgebase for drugs, drug actions and drug targets. Nucleic Acids Res. 2008 Jan;36(Database issue):D901-6. DMO2K0J RU https://pubmed.ncbi.nlm.nih.gov/18048412 DM5X7VY DI DM5X7VY DM5X7VY DN Pyrimethamine DM5X7VY MI DTI7UX6 DM5X7VY MN Breast cancer resistance protein (ABCG2) DM5X7VY MT DTP DM5X7VY MA Substrate DM5X7VY RN Mutant Gly482 and Thr482 ABCG2 mediate high-level resistance to lipophilic antifolates. Cancer Chemother Pharmacol. 2006 Dec;58(6):826-34. DM5X7VY RU https://doi.org/10.1007/s00280-006-0230-9 DM5X7VY DI DM5X7VY DM5X7VY DN Pyrimethamine DM5X7VY MI TTVC37M DM5X7VY MN Folate receptor alpha (FOLR1) DM5X7VY MT DTT DM5X7VY MA Modulator DM5X7VY RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. DM5X7VY RU https://www.fda.gov/ DM5X7VY DI DM5X7VY DM5X7VY DN Pyrimethamine DM5X7VY MI DTZGT0P DM5X7VY MN Multidrug and toxin extrusion protein 1 (SLC47A1) DM5X7VY MT DTP DM5X7VY MA Substrate DM5X7VY RN Expression of Organic Anion Transporter 1 or 3 in Human Kidney Proximal Tubule Cells Reduces Cisplatin Sensitivity. Drug Metab Dispos. 2018 May;46(5):592-599. DM5X7VY RU http://www.ncbi.nlm.nih.gov/pubmed/29514829 DMNA8HM DI DMNA8HM DMNA8HM DN Pyrithione Zinc DMNA8HM MI TTG5TOX DMNA8HM MN Fungal Proton pump (FPPCM) DMNA8HM MT DTT DMNA8HM MA Modulator DMNA8HM RN Mechanism of the antimicrobial action of pyrithione: effects on membrane transport, ATP levels, and protein synthesis. Antimicrob Agents Chemother. 1978 Jul;14(1):60-8. DMNA8HM RU https://www.ncbi.nlm.nih.gov/pubmed/28693 DMUWAM2 DI DMUWAM2 DMUWAM2 DN Pyronaridine DMUWAM2 MI TTZVSJ2 DMUWAM2 MN Sarcoplasmic/endoplasmic reticulum calcium ATPase (ATP2A) DMUWAM2 MT DTT DMUWAM2 MA Inhibitor DMUWAM2 RN The fight against drug-resistant malaria: novel plasmodial targets and antimalarial drugs. Curr Med Chem. 2008;15(2):161-71. DMUWAM2 RU https://pubmed.ncbi.nlm.nih.gov/18220771 DM7Q41G DI DM7Q41G DM7Q41G DN Pyruvic acid DM7Q41G MI TTT2LD9 DM7Q41G MN GABA transaminase (ABAT) DM7Q41G MT DTT DM7Q41G MA Inhibitor DM7Q41G RN DrugBank: a knowledgebase for drugs, drug actions and drug targets. Nucleic Acids Res. 2008 Jan;36(Database issue):D901-6. DM7Q41G RU https://pubmed.ncbi.nlm.nih.gov/18048412 DM7Q41G DI DM7Q41G DM7Q41G DN Pyruvic acid DM7Q41G MI DT342ZG DM7Q41G MN Monocarboxylate transporter 1 (SLC16A1) DM7Q41G MT DTP DM7Q41G MA Substrate DM7Q41G RN AR-C155858 is a potent inhibitor of monocarboxylate transporters MCT1 and MCT2 that binds to an intracellular site involving transmembrane helices 7-10. Biochem J. 2010 Jan 15;425(3):523-30. DM7Q41G RU https://doi.org/10.1042/BJ20091515 DMGAZHU DI DMGAZHU DMGAZHU DN Quattvaxem DMGAZHU MI TT3J5ZI DMGAZHU MN Cell mediated immunity response (CMIR) DMGAZHU MT DTT DMGAZHU RN Double-blind study comparing the immunogenicity of a licensed DTwPHib-CRM197 conjugate vaccine (Quattvaxem) with three investigational, liquid formulations using lower doses of Hib-CRM197 conjugate. Vaccine. 2005 Feb 25;23(14):1715-9. DMGAZHU RU https://pubmed.ncbi.nlm.nih.gov/15705477 DMY4D87 DI DMY4D87 DMY4D87 DN Quazepam DMY4D87 MI DE5IED8 DMY4D87 MN Cytochrome P450 2C9 (CYP2C9) DMY4D87 MT DME DMY4D87 MA Metabolism DMY4D87 RN Interaction between grapefruit juice and hypnotic drugs: comparison of triazolam and quazepam. Eur J Clin Pharmacol. 2006 Mar;62(3):209-15. DMY4D87 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=16416305 DMY4D87 DI DMY4D87 DMY4D87 DN Quazepam DMY4D87 MI DE4LYSA DMY4D87 MN Cytochrome P450 3A4 (CYP3A4) DMY4D87 MT DME DMY4D87 MA Metabolism DMY4D87 RN Interaction between grapefruit juice and hypnotic drugs: comparison of triazolam and quazepam. Eur J Clin Pharmacol. 2006 Mar;62(3):209-15. DMY4D87 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=16416305 DMY4D87 DI DMY4D87 DMY4D87 DN Quazepam DMY4D87 MI DEGTFWK DMY4D87 MN Mephenytoin 4-hydroxylase (CYP2C19) DMY4D87 MT DME DMY4D87 MA Metabolism DMY4D87 RN In vitro metabolism of quazepam in human liver and intestine and assessment of drug interactions. Xenobiotica. 2004 Nov-Dec;34(11-12):1001-11. DMY4D87 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=15801544 DMY4D87 DI DMY4D87 DMY4D87 DN Quazepam DMY4D87 MI TTPTXIN DMY4D87 MN Translocator protein (TSPO) DMY4D87 MT DTT DMY4D87 MA Modulator DMY4D87 RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. DMY4D87 RU https://www.fda.gov/ DM3NC4M DI DM3NC4M DM3NC4M DN Quercetin DM3NC4M MI TTPOI4B DM3NC4M MN Acetyl-CoA:lyso-PAF acetyltransferase (PCAT) DM3NC4M MT DTT DM3NC4M MA Inhibitor DM3NC4M RN Modulation by flavonoids of PAF and related phospholipids in endothelial cells during oxidative stress. J Lipid Res. 2003 Feb;44(2):380-7. DM3NC4M RU https://pubmed.ncbi.nlm.nih.gov/12576520 DM3NC4M DI DM3NC4M DM3NC4M DN Quercetin DM3NC4M MI DTI7UX6 DM3NC4M MN Breast cancer resistance protein (ABCG2) DM3NC4M MT DTP DM3NC4M MA Substrate DM3NC4M RN Mammalian drug efflux transporters of the ATP binding cassette (ABC) family in multidrug resistance: A review of the past decade. Cancer Lett. 2016 Jan 1;370(1):153-64. DM3NC4M RU http://www.ncbi.nlm.nih.gov/pubmed/26499806 DM3NC4M DI DM3NC4M DM3NC4M DN Quercetin DM3NC4M MI DTH6X7Q DM3NC4M MN Feline leukemia virus subgroup C receptor-related protein 1 (SLC49A1) DM3NC4M MT DTP DM3NC4M MA Substrate DM3NC4M RN The Transporter Classification Database (TCDB): recent advances. Nucleic Acids Res. 2016 Jan 4;44(D1):D372-9. (ID: 2.A.1.28.1) DM3NC4M RU http://www.tcdb.org/search/result.php?tc=2.A.1.28.1 DM3NC4M DI DM3NC4M DM3NC4M DN Quercetin DM3NC4M MI DTG3T6X DM3NC4M MN Glucose transporter type 1, erythrocyte/brain (SLC2A1) DM3NC4M MT DTP DM3NC4M MA Substrate DM3NC4M RN Oral Bioavailability and Disposition of Phytochemicals DM3NC4M RU http://cdn.intechweb.org/pdfs/25496.pdf DM3NC4M DI DM3NC4M DM3NC4M DN Quercetin DM3NC4M MI DTLT3UG DM3NC4M MN Monocarboxylate transporter 2 (SLC16A7) DM3NC4M MT DTP DM3NC4M MA Substrate DM3NC4M RN Monocarboxylate Transporters in Drug Disposition: Role in the Toxicokinetics and Toxicodynamics of the Drug of Abuse GHB. DM3NC4M RU https://www.njacs.org/wp-content/docs/2010-Spring-DrugMet-Marilyn_Morris.pdf DM3NC4M DI DM3NC4M DM3NC4M DN Quercetin DM3NC4M MI DTSYQGK DM3NC4M MN Multidrug resistance-associated protein 1 (ABCC1) DM3NC4M MT DTP DM3NC4M MA Substrate DM3NC4M RN Human intestinal transporter database: QSAR modeling and virtual profiling of drug uptake, efflux and interactions. Pharm Res. 2013 Apr;30(4):996-1007. DM3NC4M RU https://doi.org/10.1007/s11095-012-0935-x DM3NC4M DI DM3NC4M DM3NC4M DN Quercetin DM3NC4M MI DTCSGPB DM3NC4M MN Multidrug resistance-associated protein 4 (ABCC4) DM3NC4M MT DTP DM3NC4M MA Substrate DM3NC4M RN Human intestinal transporter database: QSAR modeling and virtual profiling of drug uptake, efflux and interactions. Pharm Res. 2013 Apr;30(4):996-1007. DM3NC4M RU https://doi.org/10.1007/s11095-012-0935-x DM3NC4M DI DM3NC4M DM3NC4M DN Quercetin DM3NC4M MI DTUGYRD DM3NC4M MN P-glycoprotein 1 (ABCB1) DM3NC4M MT DTP DM3NC4M MA Substrate DM3NC4M RN Flavonoid permeability across an in situ model of the blood-brain barrier. Free Radic Biol Med. 2004 Mar 1;36(5):592-604. DM3NC4M RU https://doi.org/10.1016/j.freeradbiomed.2003.11.023 DM1N62C DI DM1N62C DM1N62C DN Quetiapine DM1N62C MI DECB0K3 DM1N62C MN Cytochrome P450 2D6 (CYP2D6) DM1N62C MT DME DM1N62C MA Metabolism DM1N62C RN A liquid chromatographic-electrospray-tandem mass spectrometric method for quantitation of quetiapine in human plasma and liver microsomes: application to study in vitro metabolism. J Anal Toxicol. 2004 Sep;28(6):443-8. DM1N62C RU https://www.ncbi.nlm.nih.gov/pubmed/?term=15516294 DM1N62C DI DM1N62C DM1N62C DN Quetiapine DM1N62C MI DE4LYSA DM1N62C MN Cytochrome P450 3A4 (CYP3A4) DM1N62C MT DME DM1N62C MA Metabolism DM1N62C RN Metabolism of the active metabolite of quetiapine, N-desalkylquetiapine in vitro. Drug Metab Dispos. 2012 Sep;40(9):1778-84. DM1N62C RU https://www.ncbi.nlm.nih.gov/pubmed/?term=22688609 DM1N62C DI DM1N62C DM1N62C DN Quetiapine DM1N62C MI DEIBDNY DM1N62C MN Cytochrome P450 3A5 (CYP3A5) DM1N62C MT DME DM1N62C MA Metabolism DM1N62C RN Influence of ABCB1 and CYP3A5 genetic polymorphisms on the pharmacokinetics of quetiapine in healthy volunteers. Pharmacogenet Genomics. 2014 Jan;24(1):35-42. DM1N62C RU https://www.ncbi.nlm.nih.gov/pubmed/?term=24240480 DM1N62C DI DM1N62C DM1N62C DN Quetiapine DM1N62C MI DERD86B DM1N62C MN Cytochrome P450 3A7 (CYP3A7) DM1N62C MT DME DM1N62C MA Metabolism DM1N62C RN A liquid chromatographic-electrospray-tandem mass spectrometric method for quantitation of quetiapine in human plasma and liver microsomes: application to study in vitro metabolism. J Anal Toxicol. 2004 Sep;28(6):443-8. DM1N62C RU https://www.ncbi.nlm.nih.gov/pubmed/?term=15516294 DM1N62C DI DM1N62C DM1N62C DN Quetiapine DM1N62C MI TTEX248 DM1N62C MN Dopamine D2 receptor (D2R) DM1N62C MT DTT DM1N62C MA Agonist DM1N62C RN Receptor reserve-dependent properties of antipsychotics at human dopamine D2 receptors. Eur J Pharmacol. 2009 Apr 1;607(1-3):35-40. DM1N62C RU https://pubmed.ncbi.nlm.nih.gov/19217900 DM1N62C DI DM1N62C DM1N62C DN Quetiapine DM1N62C MI DEGTFWK DM1N62C MN Mephenytoin 4-hydroxylase (CYP2C19) DM1N62C MT DME DM1N62C MA Metabolism DM1N62C RN A liquid chromatographic-electrospray-tandem mass spectrometric method for quantitation of quetiapine in human plasma and liver microsomes: application to study in vitro metabolism. J Anal Toxicol. 2004 Sep;28(6):443-8. DM1N62C RU https://www.ncbi.nlm.nih.gov/pubmed/?term=15516294 DM1N62C DI DM1N62C DM1N62C DN Quetiapine DM1N62C MI DTUGYRD DM1N62C MN P-glycoprotein 1 (ABCB1) DM1N62C MT DTP DM1N62C MA Substrate DM1N62C RN Identification of P-glycoprotein substrates and inhibitors among psychoactive compounds--implications for pharmacokinetics of selected substrates. J Pharm Pharmacol. 2004 Aug;56(8):967-75. 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DMSWYF5 RU https://www.fda.gov/ DMSWYF5 DI DMSWYF5 DMSWYF5 DN Quinine DMSWYF5 MI DEGTFWK DMSWYF5 MN Mephenytoin 4-hydroxylase (CYP2C19) DMSWYF5 MT DME DMSWYF5 MA Metabolism DMSWYF5 RN Organic anion-transporting polypeptide B (OATP-B) and its functional comparison with three other OATPs of human liver. Gastroenterology. 2001 Feb;120(2):525-33. DMSWYF5 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=11159893 DMSWYF5 DI DMSWYF5 DMSWYF5 DN Quinine DMSWYF5 MI DTBPTJF DMSWYF5 MN Na(+)/Cl(-) betaine/GABA transporter (SLC6A12) DMSWYF5 MT DTP DMSWYF5 MA Substrate DMSWYF5 RN The Transporter Classification Database (TCDB): recent advances. Nucleic Acids Res. 2016 Jan 4;44(D1):D372-9. 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DMSWYF5 RU http://www.ncbi.nlm.nih.gov/pubmed/10525100 DMSWYF5 DI DMSWYF5 DMSWYF5 DN Quinine DMSWYF5 MI DTUGYRD DMSWYF5 MN P-glycoprotein 1 (ABCB1) DMSWYF5 MT DTP DMSWYF5 MA Substrate DMSWYF5 RN Mammalian drug efflux transporters of the ATP binding cassette (ABC) family in multidrug resistance: A review of the past decade. Cancer Lett. 2016 Jan 1;370(1):153-64. DMSWYF5 RU http://www.ncbi.nlm.nih.gov/pubmed/26499806 DM5GVHU DI DM5GVHU DM5GVHU DN Quinolones DM5GVHU MI TT0IHXV DM5GVHU MN DNA topoisomerase II (TOP2) DM5GVHU MT DTT DM5GVHU MA Inhibitor DM5GVHU RN The magic bullets and tuberculosis drug targets. Annu Rev Pharmacol Toxicol. 2005;45:529-64. DM5GVHU RU https://pubmed.ncbi.nlm.nih.gov/15822188 DM5GVHU DI DM5GVHU DM5GVHU DN Quinolones DM5GVHU MI DTE2B1D DM5GVHU MN Organic anion transporting polypeptide 1A2 (SLCO1A2) DM5GVHU MT DTP DM5GVHU MA Substrate DM5GVHU RN The Transporter Classification Database (TCDB): recent advances. Nucleic Acids Res. 2016 Jan 4;44(D1):D372-9. (ID: 2.A.60.1.14) DM5GVHU RU http://www.tcdb.org/search/result.php?tc=2.A.60.1.14 DMLKFC4 DI DMLKFC4 DMLKFC4 DN Quinupristin DMLKFC4 MI TTIB7O8 DMLKFC4 MN Bacterial Integral membrane LmrP (Bact lmrP) DMLKFC4 MT DTT DMLKFC4 MA Modulator DMLKFC4 RN The lactococcal secondary multidrug transporter LmrP confers resistance to lincosamides, macrolides, streptogramins and tetracyclines. Microbiology. 2001 Oct;147(Pt 10):2873-80. DMLKFC4 RU https://pubmed.ncbi.nlm.nih.gov/11577166 DMM4U9G DI DMM4U9G DMM4U9G DN R0-93877 DMM4U9G MI TT07C3Y DMM4U9G MN 5-HT 4 receptor (HTR4) DMM4U9G MT DTT DMM4U9G MA Agonist DMM4U9G RN Irritable bowel syndrome: new agents targeting serotonin receptor subtypes. Drugs. 2001;61(3):317-32. 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DMMZXIW RU https://www.ncbi.nlm.nih.gov/pubmed/?term=16783561 DMMZXIW DI DMMZXIW DMMZXIW DN Rabeprazole DMMZXIW MI TTF1QVM DMMZXIW MN Gastric H(+)/K(+) ATPase alpha (ATP4A) DMMZXIW MT DTT DMMZXIW MA Inhibitor DMMZXIW RN Review article: rabeprazole's tolerability profile in clinical trials. Aliment Pharmacol Ther. 1999 Oct;13 Suppl 5:17-23. DMMZXIW RU https://pubmed.ncbi.nlm.nih.gov/10555605 DMMZXIW DI DMMZXIW DMMZXIW DN Rabeprazole DMMZXIW MI DEGTFWK DMMZXIW MN Mephenytoin 4-hydroxylase (CYP2C19) DMMZXIW MT DME DMMZXIW MA Metabolism DMMZXIW RN Effects of clarithromycin and verapamil on rabeprazole pharmacokinetics between CYP2C19 genotypes. Eur J Clin Pharmacol. 2006 Aug;62(8):597-603. DMMZXIW RU https://www.ncbi.nlm.nih.gov/pubmed/?term=16783561 DMFOTZ7 DI DMFOTZ7 DMFOTZ7 DN Racecadotril DMFOTZ7 MI TT8CYO4 DMFOTZ7 MN Endopeptidase (ENP) DMFOTZ7 MT DTT DMFOTZ7 MA Modulator DMFOTZ7 RN A comprehensive review of the pharmacodynamics, pharmacokinetics, and clinical effects of the neutral endopeptidase inhibitor racecadotril. Front Pharmacol. 2012 May 30;3:93. DMFOTZ7 RU https://pubmed.ncbi.nlm.nih.gov/22661949 DMXTCVF DI DMXTCVF DMXTCVF DN Radium-223-Dichloride DMXTCVF MI TTUTN1I DMXTCVF MN Human Deoxyribonucleic acid (hDNA) DMXTCVF MT DTT DMXTCVF MA Modulator DMXTCVF RN Radium 223 dichloride for prostate cancer treatment. Drug Des Devel Ther. 2017 Sep 6;11:2643-2651. DMXTCVF RU https://pubmed.ncbi.nlm.nih.gov/28919714 DMDKF3M DI DMDKF3M DMDKF3M DN Raloxifene DMDKF3M MI DE4LYSA DMDKF3M MN Cytochrome P450 3A4 (CYP3A4) DMDKF3M MT DME DMDKF3M MA Metabolism DMDKF3M RN The role of P-glycoprotein in the bioactivation of raloxifene. Drug Metab Dispos. 2006 Dec;34(12):2073-8. DMDKF3M RU https://www.ncbi.nlm.nih.gov/pubmed/?term=16959878 DMDKF3M DI DMDKF3M DMDKF3M DN Raloxifene DMDKF3M MI TTZAYWL DMDKF3M MN Estrogen receptor (ESR) DMDKF3M MT DTT DMDKF3M MA Modulator DMDKF3M RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 620). DMDKF3M RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=620 DMDKF3M DI DMDKF3M DMDKF3M DN Raloxifene DMDKF3M MI DTUGYRD DMDKF3M MN P-glycoprotein 1 (ABCB1) DMDKF3M MT DTP DMDKF3M MA Substrate DMDKF3M RN Influence of hepatic and intestinal efflux transporters and their genetic variants on the pharmacokinetics and pharmacodynamics of raloxifene in osteoporosis treatment. Transl Res. 2012 Oct;160(4):298-308. DMDKF3M RU https://doi.org/10.1016/j.trsl.2012.03.002 DMDKF3M DI DMDKF3M DMDKF3M DN Raloxifene DMDKF3M MI DEYGVN4 DMDKF3M MN UDP-glucuronosyltransferase 1A1 (UGT1A1) DMDKF3M MT DME DMDKF3M MA Metabolism DMDKF3M RN Drug-drug interactions for UDP-glucuronosyltransferase substrates: a pharmacokinetic explanation for typically observed low exposure (AUCi/AUC) ratios. Drug Metab Dispos. 2004 Nov;32(11):1201-8. DMDKF3M RU https://www.ncbi.nlm.nih.gov/pubmed/?term=15304429 DMDKF3M DI DMDKF3M DMDKF3M DN Raloxifene DMDKF3M MI DEL5N6Y DMDKF3M MN UDP-glucuronosyltransferase 1A10 (UGT1A10) DMDKF3M MT DME DMDKF3M MA Metabolism DMDKF3M RN Characterization of raloxifene glucuronidation: potential role of UGT1A8 genotype on raloxifene metabolism in vivo. Cancer Prev Res (Phila). 2013 Jul;6(7):719-30. DMDKF3M RU https://www.ncbi.nlm.nih.gov/pubmed/?term=23682072 DMYURI6 DI DMYURI6 DMYURI6 DN Raltegravir DMYURI6 MI DE6OQ3W DMYURI6 MN Cytochrome P450 1A1 (CYP1A1) DMYURI6 MT DME DMYURI6 MA Metabolism DMYURI6 RN Exposure-related effects of atazanavir on the pharmacokinetics of raltegravir in HIV-1-infected patients. Ther Drug Monit. 2010 Dec;32(6):782-6. DMYURI6 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=20926993 DMYURI6 DI DMYURI6 DMYURI6 DN Raltegravir DMYURI6 MI TT5FH9Y DMYURI6 MN Human immunodeficiency virus Integrase (HIV IN) DMYURI6 MT DTT DMYURI6 MA Modulator DMYURI6 RN 2007 FDA drug approvals: a year of flux. Nat Rev Drug Discov. 2008 Feb;7(2):107-9. DMYURI6 RU https://pubmed.ncbi.nlm.nih.gov/18246607 DMYURI6 DI DMYURI6 DMYURI6 DN Raltegravir DMYURI6 MI DEYGVN4 DMYURI6 MN UDP-glucuronosyltransferase 1A1 (UGT1A1) DMYURI6 MT DME DMYURI6 MA Metabolism DMYURI6 RN Successful tacrolimus treatment following renal transplant in a HIV-infected patient with raltegravir previously treated with a protease inhibitor based regimen. Drug Metabol Drug Interact. 2011;26(3):139-41. DMYURI6 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=21980965 DMT9K8G DI DMT9K8G DMT9K8G DN Raltitrexed DMT9K8G MI DTI7UX6 DMT9K8G MN Breast cancer resistance protein (ABCG2) DMT9K8G MT DTP DMT9K8G MA Substrate DMT9K8G RN Pharmacogenomic importance of ABCG2. Pharmacogenomics. 2008 Aug;9(8):1005-9. DMT9K8G RU https://doi.org/10.2217/14622416.9.8.1005 DMT9K8G DI DMT9K8G DMT9K8G DN Raltitrexed DMT9K8G MI TTU6BFZ DMT9K8G MN Candida Thymidylate synthase (Candi TMP1) DMT9K8G MT DTT DMT9K8G MA Inhibitor DMT9K8G RN DNA damage and homologous recombination signaling induced by thymidylate deprivation. Biochem Pharmacol. 2008 Oct 15;76(8):987-96. DMT9K8G RU https://pubmed.ncbi.nlm.nih.gov/18773878 DMT9K8G DI DMT9K8G DMT9K8G DN Raltitrexed DMT9K8G MI DTFI42L DMT9K8G MN Multidrug resistance-associated protein 2 (ABCC2) DMT9K8G MT DTP DMT9K8G MA Substrate DMT9K8G RN Antifolate resistance mediated by the multidrug resistance proteins MRP1 and MRP2. Cancer Res. 1999 Jun 1;59(11):2532-5. DMT9K8G RU http://cancerres.aacrjournals.org/content/59/11/2532 DM7IW9J DI DM7IW9J DM7IW9J DN Ramelteon DM7IW9J MI DEJGDUW DM7IW9J MN Cytochrome P450 1A2 (CYP1A2) DM7IW9J MT DME DM7IW9J MA Metabolism DM7IW9J RN Metabolism of ramelteon in human liver microsomes and correlation with the effect of fluvoxamine on ramelteon pharmacokinetics. Drug Metab Dispos. 2010 Aug;38(8):1381-91. DM7IW9J RU https://www.ncbi.nlm.nih.gov/pubmed/?term=20478852 DM7IW9J DI DM7IW9J DM7IW9J DN Ramelteon DM7IW9J MI DE4LYSA DM7IW9J MN Cytochrome P450 3A4 (CYP3A4) DM7IW9J MT DME DM7IW9J MA Metabolism DM7IW9J RN Metabolism of ramelteon in human liver microsomes and correlation with the effect of fluvoxamine on ramelteon pharmacokinetics. Drug Metab Dispos. 2010 Aug;38(8):1381-91. 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Clin Pharmacol Ther. 1999 Apr;65(4):369-76. DM0GUSX RU https://www.ncbi.nlm.nih.gov/pubmed/?term=10223772 DM0GUSX DI DM0GUSX DM0GUSX DN Ranitidine DM0GUSX MI DECB0K3 DM0GUSX MN Cytochrome P450 2D6 (CYP2D6) DM0GUSX MT DME DM0GUSX MA Metabolism DM0GUSX RN Oxidation of ranitidine by isozymes of flavin-containing monooxygenase and cytochrome P450. Jpn J Pharmacol. 2000 Oct;84(2):213-20. DM0GUSX RU https://www.ncbi.nlm.nih.gov/pubmed/?term=11128045 DM0GUSX DI DM0GUSX DM0GUSX DN Ranitidine DM0GUSX MI DEBMX7C DM0GUSX MN Dimethylaniline oxidase 5 (FMO5) DM0GUSX MT DME DM0GUSX MA Metabolism DM0GUSX RN Drug metabolism by flavin-containing monooxygenases of human and mouse. Expert Opin Drug Metab Toxicol. 2017 Feb;13(2):167-181. 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DMHSY1I RU http://www.ncbi.nlm.nih.gov/pubmed/25739790 DMHSY1I DI DMHSY1I DMHSY1I DN Regorafenib DMHSY1I MI DT3D8F0 DMHSY1I MN Organic anion transporting polypeptide 1B1 (SLCO1B1) DMHSY1I MT DTP DMHSY1I MA Substrate DMHSY1I RN Regorafenib is transported by the organic anion transporter 1B1 and the multidrug resistance protein 2. Biol Pharm Bull. 2015;38(4):582-6. DMHSY1I RU http://www.ncbi.nlm.nih.gov/pubmed/25739790 DMHSY1I DI DMHSY1I DMHSY1I DN Regorafenib DMHSY1I MI DTUGYRD DMHSY1I MN P-glycoprotein 1 (ABCB1) DMHSY1I MT DTP DMHSY1I MA Substrate DMHSY1I RN Brain and Testis Accumulation of Regorafenib is Restricted by Breast Cancer Resistance Protein (BCRP/ABCG2) and P-glycoprotein (P-GP/ABCB1). Pharm Res. 2015 Jul;32(7):2205-16. DMHSY1I RU http://www.ncbi.nlm.nih.gov/pubmed/25563977 DMHSY1I DI DMHSY1I DMHSY1I DN Regorafenib DMHSY1I MI TT4DXQT DMHSY1I MN Proto-oncogene c-Ret (RET) DMHSY1I MT DTT DMHSY1I MA Modulator DMHSY1I RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015 DMHSY1I RU https://www.accessdata.fda.gov/scripts/cder/drugsatfda/ DMHSY1I DI DMHSY1I DMHSY1I DN Regorafenib DMHSY1I MI TTX41N9 DMHSY1I MN Tyrosine-protein kinase Kit (KIT) DMHSY1I MT DTT DMHSY1I MA Modulator DMHSY1I RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015 DMHSY1I RU https://www.accessdata.fda.gov/scripts/cder/drugsatfda/ DMHSY1I DI DMHSY1I DMHSY1I DN Regorafenib DMHSY1I MI DE85D2P DMHSY1I MN UDP-glucuronosyltransferase 1A9 (UGT1A9) DMHSY1I MT DME DMHSY1I MA Metabolism DMHSY1I RN FDA Label of Regorafenib. The 2020 official website of the U.S. Food and Drug Administration. DMHSY1I RU https://www.accessdata.fda.gov/drugsatfda_docs/label/2012/203085lbl.pdf DMHSY1I DI DMHSY1I DMHSY1I DN Regorafenib DMHSY1I MI TTUTJGQ DMHSY1I MN Vascular endothelial growth factor receptor 2 (KDR) DMHSY1I MT DTT DMHSY1I MA Modulator DMHSY1I RN Drugs@FDA. U.S. Food and Drug Administration. 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DM5SXUV RU https://pubmed.ncbi.nlm.nih.gov/19478691 DM5SXUV DI DM5SXUV DM5SXUV DN Repaglinide DM5SXUV MI DES5XRU DM5SXUV MN Cytochrome P450 2C8 (CYP2C8) DM5SXUV MT DME DM5SXUV MA Metabolism DM5SXUV RN Drug-drug and food-drug pharmacokinetic interactions with new insulinotropic agents repaglinide and nateglinide. Clin Pharmacokinet. 2007;46(2):93-108. DM5SXUV RU https://www.ncbi.nlm.nih.gov/pubmed/?term=17253883 DM5SXUV DI DM5SXUV DM5SXUV DN Repaglinide DM5SXUV MI DE4LYSA DM5SXUV MN Cytochrome P450 3A4 (CYP3A4) DM5SXUV MT DME DM5SXUV MA Metabolism DM5SXUV RN Drug-drug and food-drug pharmacokinetic interactions with new insulinotropic agents repaglinide and nateglinide. Clin Pharmacokinet. 2007;46(2):93-108. DM5SXUV RU https://www.ncbi.nlm.nih.gov/pubmed/?term=17253883 DM5SXUV DI DM5SXUV DM5SXUV DN Repaglinide DM5SXUV MI DT3D8F0 DM5SXUV MN Organic anion transporting polypeptide 1B1 (SLCO1B1) DM5SXUV MT DTP DM5SXUV MA Substrate DM5SXUV RN Disease-Associated Changes in Drug Transporters May Impact the Pharmacokinetics and/or Toxicity of Drugs: A White Paper From the International Transporter Consortium. Clin Pharmacol Ther. 2018 Nov;104(5):900-915. DM5SXUV RU http://www.ncbi.nlm.nih.gov/pubmed/29756222 DM5SXUV DI DM5SXUV DM5SXUV DN Repaglinide DM5SXUV MI DEYGVN4 DM5SXUV MN UDP-glucuronosyltransferase 1A1 (UGT1A1) DM5SXUV MT DME DM5SXUV MA Metabolism DM5SXUV RN Repaglinide-gemfibrozil drug interaction: inhibition of repaglinide glucuronidation as a potential additional contributing mechanism. Br J Clin Pharmacol. 2010 Dec;70(6):870-80. DM5SXUV RU https://www.ncbi.nlm.nih.gov/pubmed/?term=21175442 DM6KI0D DI DM6KI0D DM6KI0D DN Repirinast DM6KI0D MI TT7CXIM DM6KI0D MN Histamine receptor (HR) DM6KI0D MT DTT DM6KI0D MA Modulator DM6KI0D RN Mechanism of action of MY-1250, an active metabolite of Repirinast, in inhibiting histamine release from rat mast cells. Br J Pharmacol. 1992 Mar;105(3):587-90. DM6KI0D RU https://pubmed.ncbi.nlm.nih.gov/1378339 DMG7SQK DI DMG7SQK DMG7SQK DN Rescinnamine DMG7SQK MI TTL69WB DMG7SQK MN Angiotensin-converting enzyme (ACE) DMG7SQK MT DTT DMG7SQK MA Inhibitor DMG7SQK RN Colorimetric determination of indolic drugs. Pak J Pharm Sci. 2005 Apr;18(2):48-51. DMG7SQK RU https://pubmed.ncbi.nlm.nih.gov/16431399 DM6VM38 DI DM6VM38 DM6VM38 DN Reserpine DM6VM38 MI DTI7UX6 DM6VM38 MN Breast cancer resistance protein (ABCG2) DM6VM38 MT DTP DM6VM38 MA Substrate DM6VM38 RN Mammalian drug efflux transporters of the ATP binding cassette (ABC) family in multidrug resistance: A review of the past decade. Cancer Lett. 2016 Jan 1;370(1):153-64. DM6VM38 RU http://www.ncbi.nlm.nih.gov/pubmed/26499806 DM6VM38 DI DM6VM38 DM6VM38 DN Reserpine DM6VM38 MI DTUGYRD DM6VM38 MN P-glycoprotein 1 (ABCB1) DM6VM38 MT DTP DM6VM38 MA Substrate DM6VM38 RN Improving the prediction of the brain disposition for orally administered drugs using BDDCS. Adv Drug Deliv Rev. 2012 Jan;64(1):95-109. DM6VM38 RU https://doi.org/10.1016/j.addr.2011.12.008 DM6VM38 DI DM6VM38 DM6VM38 DN Reserpine DM6VM38 MI TTNZRI3 DM6VM38 MN Synaptic vesicle amine transporter (SLC18A2) DM6VM38 MT DTT DM6VM38 MA Blocker DM6VM38 RN Dopamine signaling is required for depolarization-induced slow current in cerebellar Purkinje cells. J Neurosci. 2009 Jul 1;29(26):8530-8. DM6VM38 RU https://pubmed.ncbi.nlm.nih.gov/19571144 DM0AUCH DI DM0AUCH DM0AUCH DN Reslizumab DM0AUCH MI TTPREZD DM0AUCH MN Interleukin-5 (IL5) DM0AUCH MT DTT DM0AUCH MA Modulator DM0AUCH RN The potential of biologics for the treatment of asthma. Nat Rev Drug Discov. 2012 Dec;11(12):958-72. DM0AUCH RU https://www.ncbi.nlm.nih.gov/pubmed/23197041 DM9JXB7 DI DM9JXB7 DM9JXB7 DN Retapamulin DM9JXB7 MI TTUWYEA DM9JXB7 MN Bacterial 50S ribosomal RNA (Bact 50S rRNA) DM9JXB7 MT DTT DM9JXB7 MA Inhibitor DM9JXB7 RN Retapamulin inhibition of translation and 50S ribosomal subunit formation in Staphylococcus aureus cells. Antimicrob Agents Chemother. 2007 Sep;51(9):3385-7. DM9JXB7 RU https://pubmed.ncbi.nlm.nih.gov/17562806 DML0D1P DI DML0D1P DML0D1P DN Reteplase DML0D1P MI TTP86E2 DML0D1P MN Plasminogen (PLG) DML0D1P MT DTT DML0D1P MA Activator DML0D1P RN Fibrin binding and the regulation of plasminogen activators during thrombolytic therapy. Cardiovasc Hematol Agents Med Chem. 2008 Jul;6(3):212-23. DML0D1P RU https://pubmed.ncbi.nlm.nih.gov/18673235 DMGNYIH DI DMGNYIH DMGNYIH DN Retigabine DMGNYIH MI DE6OQ3W DMGNYIH MN Cytochrome P450 1A1 (CYP1A1) DMGNYIH MT DME DMGNYIH MA Metabolism DMGNYIH RN Retigabine N-glucuronidation and its potential role in enterohepatic circulation. Drug Metab Dispos. 1999 May;27(5):605-12. DMGNYIH RU https://www.ncbi.nlm.nih.gov/pubmed/?term=10220490 DMGNYIH DI DMGNYIH DMGNYIH DN Retigabine DMGNYIH MI DEYGVN4 DMGNYIH MN UDP-glucuronosyltransferase 1A1 (UGT1A1) DMGNYIH MT DME DMGNYIH MA Metabolism DMGNYIH RN N-Glucuronidation of the antiepileptic drug retigabine: results from studies with human volunteers, heterologously expressed human UGTs, human liver, kidney, and liver microsomal membranes of Crigler-Najjar type II. Metabolism. 2006 Jun;55(6):711-21. DMGNYIH RU https://www.ncbi.nlm.nih.gov/pubmed/?term=16713428 DMGNYIH DI DMGNYIH DMGNYIH DN Retigabine DMGNYIH MI DEF2WXN DMGNYIH MN UDP-glucuronosyltransferase 1A3 (UGT1A3) DMGNYIH MT DME DMGNYIH MA Metabolism DMGNYIH RN Retigabine N-glucuronidation and its potential role in enterohepatic circulation. Drug Metab Dispos. 1999 May;27(5):605-12. DMGNYIH RU https://www.ncbi.nlm.nih.gov/pubmed/?term=10220490 DMGNYIH DI DMGNYIH DMGNYIH DN Retigabine DMGNYIH MI DE85D2P DMGNYIH MN UDP-glucuronosyltransferase 1A9 (UGT1A9) DMGNYIH MT DME DMGNYIH MA Metabolism DMGNYIH RN Retigabine N-glucuronidation and its potential role in enterohepatic circulation. Drug Metab Dispos. 1999 May;27(5):605-12. DMGNYIH RU https://www.ncbi.nlm.nih.gov/pubmed/?term=10220490 DMGNYIH DI DMGNYIH DMGNYIH DN Retigabine DMGNYIH MI TTQ29KF DMGNYIH MN Voltage-gated potassium channel Kv7 (KCNQ) DMGNYIH MT DTT DMGNYIH MA Activator DMGNYIH RN Antibodies and venom peptides: new modalities for ion channels. Nat Rev Drug Discov. 2019 May;18(5):339-357. DMGNYIH RU https://pubmed.ncbi.nlm.nih.gov/30728472 DMGNYIH DI DMGNYIH DMGNYIH DN Retigabine DMGNYIH MI TTIVDM3 DMGNYIH MN Voltage-gated potassium channel Kv7.3 (KCNQ3) DMGNYIH MT DTT DMGNYIH MA Modulator DMGNYIH RN The urinary safety profile and secondary renal effects of retigabine (ezogabine): a first-in-class antiepileptic drug that targets KCNQ (K(v)7) potassium channels. Epilepsia. 2012 Apr;53(4):606-12. DMGNYIH RU https://pubmed.ncbi.nlm.nih.gov/22428574 DMMP5SI DI DMMP5SI DMMP5SI DN Revefenacin DMMP5SI MI DECB0K3 DMMP5SI MN Cytochrome P450 2D6 (CYP2D6) DMMP5SI MT DME DMMP5SI MA Metabolism DMMP5SI RN A 28-day, randomized, double-blind, placebo-controlled, parallel group study of nebulized revefenacin in patients with chronic obstructive pulmonary disease. Respir Res. 2017 Nov 2;18(1):182. DMMP5SI RU https://www.ncbi.nlm.nih.gov/pubmed/?term=29096627 DMMP5SI DI DMMP5SI DMMP5SI DN Revefenacin DMMP5SI MI TTOXS3C DMMP5SI MN Muscarinic acetylcholine receptor (CHRM) DMMP5SI MT DTT DMMP5SI MA Antagonist DMMP5SI RN 2018 FDA drug approvals.Nat Rev Drug Discov. 2019 Feb;18(2):85-89. DMMP5SI RU https://pubmed.ncbi.nlm.nih.gov/30710142 DM8LRU2 DI DM8LRU2 DM8LRU2 DN Revolade/Promacta DM8LRU2 MI TTIHYA4 DM8LRU2 MN Thrombopoietin receptor (MPL) DM8LRU2 MT DTT DM8LRU2 MA Agonist DM8LRU2 RN Clinical pipeline report, company report or official report of GlaxoSmithKline (2009). DM8LRU2 RU http://www.gsk.com/investors/product_pipeline/docs/gsk-pipeline-feb09.pdf DM69XMQ DI DM69XMQ DM69XMQ DN RG-7446 DM69XMQ MI TT8ZLTI DM69XMQ MN Programmed cell death 1 ligand 1 (PD-L1) DM69XMQ MT DTT DM69XMQ RN PD-1 as a potential target in cancer therapy. Cancer Med. 2013 October; 2(5): 662-673. DM69XMQ RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3892798/ DMNF0G8 DI DMNF0G8 DMNF0G8 DN Rh-alphaglucosidase DMNF0G8 MI TTXWASR DMNF0G8 MN Intestinal maltase-glucoamylase (MGAM) DMNF0G8 MT DTT DMNF0G8 MA Modulator DMNF0G8 RN 2006 drug approvals: finding the niche. Nat Rev Drug Discov. 2007 Feb;6(2):99-101. DMNF0G8 RU https://pubmed.ncbi.nlm.nih.gov/17342860 DM3ADGP DI DM3ADGP DM3ADGP DN Rhucin DM3ADGP MI TTVQ6R9 DM3ADGP MN C1 esterase inhibitor (SERPING1) DM3ADGP MT DTT DM3ADGP MA Modulator DM3ADGP RN Mullard A: 2010 FDA drug approvals. Nat Rev Drug Discov. 2011 Feb;10(2):82-5. DM3ADGP RU https://pubmed.ncbi.nlm.nih.gov/21283092 DM3ADGP DI DM3ADGP DM3ADGP DN Rhucin DM3ADGP MI TTJ0IQB DM3ADGP MN Phosphodiesterase 5A (PDE5A) DM3ADGP MT DTT DM3ADGP MA Inhibitor DM3ADGP RN cGMP-hydrolytic activity and its inhibition by sildenafil in normal and failing human and mouse myocardium. J Pharmacol Exp Ther. 2009 Sep;330(3):884-91. DM3ADGP RU https://pubmed.ncbi.nlm.nih.gov/19546307 DMALNG0 DI DMALNG0 DMALNG0 DN RHuEPO DMALNG0 MI TTAUX24 DMALNG0 MN Erythropoietin Receptor (EPOR) DMALNG0 MT DTT DMALNG0 MA Stimulator DMALNG0 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1718). DMALNG0 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1718 DMEYLH9 DI DMEYLH9 DMEYLH9 DN Ribavirin DMEYLH9 MI DT4YL5R DMEYLH9 MN Concentrative Na(+)-nucleoside cotransporter 3 (SLC28A3) DMEYLH9 MT DTP DMEYLH9 MA Substrate DMEYLH9 RN Kinetic study of anti-viral ribavirin uptake mediated by hCNT3 and hENT1 in Xenopus laevis oocytes. Biophys Chem. 2010 Mar;147(1-2):59-65. DMEYLH9 RU http://www.ncbi.nlm.nih.gov/pubmed/20096989 DMEYLH9 DI DMEYLH9 DMEYLH9 DN Ribavirin DMEYLH9 MI DT82KPY DMEYLH9 MN Concentrative nucleoside transporter 2 (SLC28A2) DMEYLH9 MT DTP DMEYLH9 MA Substrate DMEYLH9 RN Identification and functional analysis of variants in the human concentrative nucleoside transporter 2, hCNT2 (SLC28A2) in Chinese, Malays and Indians. Pharmacogenet Genomics. 2007 Sep;17(9):783-6. DMEYLH9 RU http://www.ncbi.nlm.nih.gov/pubmed/17700367 DMEYLH9 DI DMEYLH9 DMEYLH9 DN Ribavirin DMEYLH9 MI DE1DOKJ DMEYLH9 MN Cytosolic 5'-nucleotidase II (NT5C2) DMEYLH9 MT DME DMEYLH9 MA Metabolism DMEYLH9 RN Phosphorylation of ribavirin and viramidine by adenosine kinase and cytosolic 5'-nucleotidase II: Implications for ribavirin metabolism in erythrocytes. Antimicrob Agents Chemother. 2005 Jun;49(6):2164-71. DMEYLH9 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=15917509 DMEYLH9 DI DMEYLH9 DMEYLH9 DN Ribavirin DMEYLH9 MI DTXD1TQ DMEYLH9 MN Equilibrative nucleoside transporter 1 (SLC29A1) DMEYLH9 MT DTP DMEYLH9 MA Substrate DMEYLH9 RN Effects of dipyridamole coadministration on the pharmacokinetics of ribavirin in healthy volunteers. Drug Metab Pharmacokinet. 2013;28(5):406-10. DMEYLH9 RU http://www.ncbi.nlm.nih.gov/pubmed/23459628 DMEYLH9 DI DMEYLH9 DMEYLH9 DN Ribavirin DMEYLH9 MI TTL7C8Q DMEYLH9 MN Inosine-5'-monophosphate dehydrogenase 1 (IMPDH1) DMEYLH9 MT DTT DMEYLH9 MA Inhibitor DMEYLH9 RN Treating HCV with ribavirin analogues and ribavirin-like molecules. J Antimicrob Chemother. 2006 Jan;57(1):8-13. DMEYLH9 RU https://pubmed.ncbi.nlm.nih.gov/16293677 DMEYLH9 DI DMEYLH9 DMEYLH9 DN Ribavirin DMEYLH9 MI DT9G7XN DMEYLH9 MN Peptide transporter 1 (SLC15A1) DMEYLH9 MT DTP DMEYLH9 MA Substrate DMEYLH9 RN Transport of levovirin prodrugs in the human intestinal Caco-2 cell line. J Pharm Sci. 2006 Jun;95(6):1318-25. DMEYLH9 RU https://doi.org/10.1002/jps.20434 DMEYLH9 DI DMEYLH9 DMEYLH9 DN Ribavirin DMEYLH9 MI DE2WSAL DMEYLH9 MN Purine nucleoside phosphorylase (PNP) DMEYLH9 MT DME DMEYLH9 MA Metabolism DMEYLH9 RN Functional analysis of purine nucleoside phosphorylase as a key enzyme in ribavirin metabolism. Drug Metab Pharmacokinet. 2014;29(2):211-4. DMEYLH9 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=24107682 DM9CIUW DI DM9CIUW DM9CIUW DN Ribociclib succinate DM9CIUW MI TT0PG8F DM9CIUW MN Cyclin-dependent kinase 4 (CDK4) DM9CIUW MT DTT DM9CIUW MA Modulator DM9CIUW RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. DM9CIUW RU https://www.fda.gov/ DM9CIUW DI DM9CIUW DM9CIUW DN Ribociclib succinate DM9CIUW MI TTO0FDJ DM9CIUW MN Cyclin-dependent kinase 6 (CDK6) DM9CIUW MT DTT DM9CIUW MA Modulator DM9CIUW RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. DM9CIUW RU https://www.fda.gov/ DM9CIUW DI DM9CIUW DM9CIUW DN Ribociclib succinate DM9CIUW MI DE4LYSA DM9CIUW MN Cytochrome P450 3A4 (CYP3A4) DM9CIUW MT DME DM9CIUW MA Metabolism DM9CIUW RN P-glycoprotein limits ribociclib brain exposure and CYP3A4 restricts its oral bioavailability. Mol Pharm. 2019 Sep 3;16(9):3842-3852. DM9CIUW RU https://www.ncbi.nlm.nih.gov/pubmed/?term=31329454 DM8YMWE DI DM8YMWE DM8YMWE DN Riboflavin DM8YMWE MI DER6BCE DM8YMWE MN Acid phosphatase-like protein 1 (ACP6) DM8YMWE MT DME DM8YMWE MA Metabolism DM8YMWE RN An atlas of human metabolism. Sci Signal. 2020 Mar 24;13(624). pii: eaaz1482. (Reaction HMR_6507) DM8YMWE RU https://www.metabolicatlas.org/explore/gem-browser/human1/reaction/HMR_6507 DM8YMWE DI DM8YMWE DM8YMWE DN Riboflavin DM8YMWE MI DTI7UX6 DM8YMWE MN Breast cancer resistance protein (ABCG2) DM8YMWE MT DTP DM8YMWE MA Substrate DM8YMWE RN Multidrug transporter ABCG2/breast cancer resistance protein secretes riboflavin (vitamin B2) into milk. Mol Cell Biol. 2007 Feb;27(4):1247-53. DM8YMWE RU http://www.ncbi.nlm.nih.gov/pubmed/17145775 DM8YMWE DI DM8YMWE DM8YMWE DN Riboflavin DM8YMWE MI DE6OQ3W DM8YMWE MN Cytochrome P450 1A1 (CYP1A1) DM8YMWE MT DME DM8YMWE MA Metabolism DM8YMWE RN Disruption of endogenous regulator homeostasis underlies the mechanism of rat CYP1A1 mRNA induction by metyrapone. Biochem J. 1998 Apr 1;331 ( Pt 1):273-81. DM8YMWE RU https://www.ncbi.nlm.nih.gov/pubmed/?term=9512490 DM8YMWE DI DM8YMWE DM8YMWE DN Riboflavin DM8YMWE MI DETE84Z DM8YMWE MN Eosinophil peroxidase (EPX) DM8YMWE MT DME DM8YMWE MA Metabolism DM8YMWE RN An atlas of human metabolism. Sci Signal. 2020 Mar 24;13(624). pii: eaaz1482. (Reaction HMR_6507) DM8YMWE RU https://www.metabolicatlas.org/explore/gem-browser/human1/reaction/HMR_6507 DM8YMWE DI DM8YMWE DM8YMWE DN Riboflavin DM8YMWE MI DE21PLI DM8YMWE MN NADPH-dependent nitroreductase (nfrA1) DM8YMWE MT DME DM8YMWE MA Metabolism DM8YMWE RN Conversion of NfsA, the major Escherichia coli nitroreductase, to a flavin reductase with an activity similar to that of Frp, a flavin reductase in Vibrio harveyi, by a single amino acid substitution. J Bacteriol. 1998 Jan;180(2):422-5. DM8YMWE RU https://pubmed.ncbi.nlm.nih.gov/9440535 DM8YMWE DI DM8YMWE DM8YMWE DN Riboflavin DM8YMWE MI DE82GV7 DM8YMWE MN NADPH-dependent oxidoreductase (nfrA) DM8YMWE MT DME DM8YMWE MA Metabolism DM8YMWE RN Reduction of polynitroaromatic compounds: the bacterial nitroreductases. FEMS Microbiol Rev. 2008 May;32(3):474-500. DM8YMWE RU https://pubmed.ncbi.nlm.nih.gov/18355273 DM8YMWE DI DM8YMWE DM8YMWE DN Riboflavin DM8YMWE MI DE0K82S DM8YMWE MN Nitroreductase (NTR) DM8YMWE MT DME DM8YMWE MA Metabolism DM8YMWE RN Purification and characterization of wild-type and mutant "classical" nitroreductases of Salmonella typhimurium. L33R mutation greatly diminishes binding of FMN to the nitroreductase of S. typhimurium. J Biol Chem. 1998 Sep 11;273(37):23922-8. DM8YMWE RU https://pubmed.ncbi.nlm.nih.gov/9727006 DM8YMWE DI DM8YMWE DM8YMWE DN Riboflavin DM8YMWE MI DEDW5H6 DM8YMWE MN Prostatic acid phosphatase (ACP3) DM8YMWE MT DME DM8YMWE MA Metabolism DM8YMWE RN An atlas of human metabolism. Sci Signal. 2020 Mar 24;13(624). pii: eaaz1482. (Reaction HMR_6507) DM8YMWE RU https://www.metabolicatlas.org/explore/gem-browser/human1/reaction/HMR_6507 DM8YMWE DI DM8YMWE DM8YMWE DN Riboflavin DM8YMWE MI DT7NOKR DM8YMWE MN Riboflavin transporter 1 (SLC52A1) DM8YMWE MT DTP DM8YMWE MA Substrate DM8YMWE RN An intronic variation in SLC52A1 causes exon skipping and transient riboflavin-responsive multiple acyl-CoA dehydrogenation deficiency. Mol Genet Metab. 2017 Dec;122(4):182-188. DM8YMWE RU http://www.ncbi.nlm.nih.gov/pubmed/29122468 DM8YMWE DI DM8YMWE DM8YMWE DN Riboflavin DM8YMWE MI DTBVQIO DM8YMWE MN Riboflavin transporter 2 (SLC52A3) DM8YMWE MT DTP DM8YMWE MA Substrate DM8YMWE RN An intronic variation in SLC52A1 causes exon skipping and transient riboflavin-responsive multiple acyl-CoA dehydrogenation deficiency. Mol Genet Metab. 2017 Dec;122(4):182-188. DM8YMWE RU http://www.ncbi.nlm.nih.gov/pubmed/29122468 DM8YMWE DI DM8YMWE DM8YMWE DN Riboflavin DM8YMWE MI DTAVOS6 DM8YMWE MN Riboflavin transporter 3 (SLC52A2) DM8YMWE MT DTP DM8YMWE MA Substrate DM8YMWE RN An intronic variation in SLC52A1 causes exon skipping and transient riboflavin-responsive multiple acyl-CoA dehydrogenation deficiency. Mol Genet Metab. 2017 Dec;122(4):182-188. DM8YMWE RU http://www.ncbi.nlm.nih.gov/pubmed/29122468 DM8YMWE DI DM8YMWE DM8YMWE DN Riboflavin DM8YMWE MI DESITDW DM8YMWE MN Tartrate-resistant acid ATPase (ACP5) DM8YMWE MT DME DM8YMWE MA Metabolism DM8YMWE RN An atlas of human metabolism. Sci Signal. 2020 Mar 24;13(624). pii: eaaz1482. (Reaction HMR_6507) DM8YMWE RU https://www.metabolicatlas.org/explore/gem-browser/human1/reaction/HMR_6507 DM8YMWE DI DM8YMWE DM8YMWE DN Riboflavin DM8YMWE MI DE3OZT4 DM8YMWE MN Testicular acid phosphatase (ACP4) DM8YMWE MT DME DM8YMWE MA Metabolism DM8YMWE RN An atlas of human metabolism. Sci Signal. 2020 Mar 24;13(624). pii: eaaz1482. (Reaction HMR_6507) DM8YMWE RU https://www.metabolicatlas.org/explore/gem-browser/human1/reaction/HMR_6507 DM8YMWE DI DM8YMWE DM8YMWE DN Riboflavin DM8YMWE MI DEGSUI0 DM8YMWE MN Xylosyl phosphatase (PXYLP1) DM8YMWE MT DME DM8YMWE MA Metabolism DM8YMWE RN An atlas of human metabolism. Sci Signal. 2020 Mar 24;13(624). pii: eaaz1482. (Reaction HMR_6507) DM8YMWE RU https://www.metabolicatlas.org/explore/gem-browser/human1/reaction/HMR_6507 DMWH9CN DI DMWH9CN DMWH9CN DN Ridogrel DMWH9CN MI TT2O84V DMWH9CN MN Thromboxane A2 receptor (TBXA2R) DMWH9CN MT DTT DMWH9CN MA Binder DMWH9CN RN Chronic ouabain treatment exacerbates blood pressure elevation in spontaneously hypertensive rats: the role of vascular mechanisms. J Hypertens. 2009 Jun;27(6):1233-42. DMWH9CN RU https://pubmed.ncbi.nlm.nih.gov/19337130 DM1YBHK DI DM1YBHK DM1YBHK DN Rifabutin DM1YBHK MI DE4LYSA DM1YBHK MN Cytochrome P450 3A4 (CYP3A4) DM1YBHK MT DME DM1YBHK MA Metabolism DM1YBHK RN The effect of multiple doses of ritonavir on the pharmacokinetics of rifabutin. Clin Pharmacol Ther. 1998 Apr;63(4):414-21. DM1YBHK RU https://www.ncbi.nlm.nih.gov/pubmed/?term=9585795 DM1YBHK DI DM1YBHK DM1YBHK DN Rifabutin DM1YBHK MI TTHKJLN DM1YBHK MN DNA-directed RNA polymerase (RNAP) DM1YBHK MT DTT DM1YBHK MA Modulator DM1YBHK RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. DM1YBHK RU https://www.fda.gov/ DM5DSFZ DI DM5DSFZ DM5DSFZ DN Rifampicin DM5DSFZ MI DEJGDUW DM5DSFZ MN Cytochrome P450 1A2 (CYP1A2) DM5DSFZ MT DME DM5DSFZ MA Metabolism DM5DSFZ RN Effects of prototypical microsomal enzyme inducers on cytochrome P450 expression in cultured human hepatocytes. Drug Metab Dispos. 2003 Apr;31(4):421-31. DM5DSFZ RU https://www.ncbi.nlm.nih.gov/pubmed/?term=12642468 DM5DSFZ DI DM5DSFZ DM5DSFZ DN Rifampicin DM5DSFZ MI DEPKLMQ DM5DSFZ MN Cytochrome P450 2B6 (CYP2B6) DM5DSFZ MT DME DM5DSFZ MA Metabolism DM5DSFZ RN Cytochrome P450 2B6 activity as measured by bupropion hydroxylation: effect of induction by rifampin and ethnicity. Clin Pharmacol Ther. 2006 Jul;80(1):75-84. DM5DSFZ RU https://www.ncbi.nlm.nih.gov/pubmed/?term=16815319 DM5DSFZ DI DM5DSFZ DM5DSFZ DN Rifampicin DM5DSFZ MI DE5IED8 DM5DSFZ MN Cytochrome P450 2C9 (CYP2C9) DM5DSFZ MT DME DM5DSFZ MA Metabolism DM5DSFZ RN Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. DM5DSFZ RU https://www.ncbi.nlm.nih.gov/pubmed/?term=19515014 DM5DSFZ DI DM5DSFZ DM5DSFZ DN Rifampicin DM5DSFZ MI DECB0K3 DM5DSFZ MN Cytochrome P450 2D6 (CYP2D6) DM5DSFZ MT DME DM5DSFZ MA Metabolism DM5DSFZ RN Xenobiotic-metabolizing cytochromes p450 in human white adipose tissue: expression and induction. Drug Metab Dispos. 2010 Apr;38(4):679-86. DM5DSFZ RU https://www.ncbi.nlm.nih.gov/pubmed/?term=20035023 DM5DSFZ DI DM5DSFZ DM5DSFZ DN Rifampicin DM5DSFZ MI DEVDYN7 DM5DSFZ MN Cytochrome P450 2E1 (CYP2E1) DM5DSFZ MT DME DM5DSFZ MA Metabolism DM5DSFZ RN Protective effect of rifampicin against acute liver injury induced by carbon tetrachloride in mice. Jpn J Pharmacol. 1995 Dec;69(4):325-34. DM5DSFZ RU https://www.ncbi.nlm.nih.gov/pubmed/?term=8786635 DM5DSFZ DI DM5DSFZ DM5DSFZ DN Rifampicin DM5DSFZ MI DE4LYSA DM5DSFZ MN Cytochrome P450 3A4 (CYP3A4) DM5DSFZ MT DME DM5DSFZ MA Metabolism DM5DSFZ RN Ketoconazole and rifampin significantly affect the pharmacokinetics, but not the safety or QTc interval, of casopitant, a neurokinin-1 receptor antagonist. J Clin Pharmacol. 2010 Aug;50(8):951-9. DM5DSFZ RU https://www.ncbi.nlm.nih.gov/pubmed/?term=20124517 DM5DSFZ DI DM5DSFZ DM5DSFZ DN Rifampicin DM5DSFZ MI DEGTFWK DM5DSFZ MN Mephenytoin 4-hydroxylase (CYP2C19) DM5DSFZ MT DME DM5DSFZ MA Metabolism DM5DSFZ RN Rifampin markedly decreases plasma concentrations of praziquantel in healthy volunteers. Clin Pharmacol Ther. 2002 Nov;72(5):505-13. DM5DSFZ RU https://www.ncbi.nlm.nih.gov/pubmed/?term=12426514 DM5DSFZ DI DM5DSFZ DM5DSFZ DN Rifampicin DM5DSFZ MI DE6PKFB DM5DSFZ MN Rifampicin monooxygenase (rox) DM5DSFZ MT DME DM5DSFZ MA Metabolism DM5DSFZ RN Mechanism of rifampicin inactivation in Nocardia farcinica. PLoS One. 2016 Oct 5;11(10):e0162578. DM5DSFZ RU https://pubmed.ncbi.nlm.nih.gov/27706151 DMA8J1G DI DMA8J1G DMA8J1G DN Rifampin DMA8J1G MI TTIJ5EB DMA8J1G MN Bacterial RNA polymerase switch region (Bact RNAP-SR) DMA8J1G MT DTT DMA8J1G MA Inhibitor DMA8J1G RN Bacillus subtilis tolerance of moderate concentrations of rifampin involves the sigma(B)-dependent general and multiple stress response. J Bacteriol. 2002 Jan;184(2):459-67. DMA8J1G RU https://pubmed.ncbi.nlm.nih.gov/11751823 DMA8J1G DI DMA8J1G DMA8J1G DN Rifampin DMA8J1G MI DTI7UX6 DMA8J1G MN Breast cancer resistance protein (ABCG2) DMA8J1G MT DTP DMA8J1G MA Substrate DMA8J1G RN Arginine-482 is not essential for transport of antibiotics, primary bile acids and unconjugated sterols by the human breast cancer resistance protein (ABCG2). Biochem J. 2005 Jan 15;385(Pt 2):419-26. DMA8J1G RU https://doi.org/10.1042/BJ20040791 DMA8J1G DI DMA8J1G DMA8J1G DN Rifampin DMA8J1G MI DTFI42L DMA8J1G MN Multidrug resistance-associated protein 2 (ABCC2) DMA8J1G MT DTP DMA8J1G MA Substrate DMA8J1G RN Expression and distribution of CYP3A genes, CYP2B22, and MDR1, MRP1, MRP2, LRP efflux transporters in brain of control and rifampicin-treated pigs. Mol Cell Biochem. 2010 Apr;337(1-2):133-43. DMA8J1G RU http://www.ncbi.nlm.nih.gov/pubmed/19844775 DMA8J1G DI DMA8J1G DMA8J1G DN Rifampin DMA8J1G MI DT3D8F0 DMA8J1G MN Organic anion transporting polypeptide 1B1 (SLCO1B1) DMA8J1G MT DTP DMA8J1G MA Substrate DMA8J1G RN Human organic anion transporting polypeptide-C (SLC21A6) is a major determinant of rifampin-mediated pregnane X receptor activation. J Pharmacol Exp Ther. 2003 Jan;304(1):223-8. DMA8J1G RU http://www.ncbi.nlm.nih.gov/pubmed/12490595 DMA8J1G DI DMA8J1G DMA8J1G DN Rifampin DMA8J1G MI DT9C1TS DMA8J1G MN Organic anion transporting polypeptide 1B3 (SLCO1B3) DMA8J1G MT DTP DMA8J1G MA Substrate DMA8J1G RN Interactions of rifamycin SV and rifampicin with organic anion uptake systems of human liver. Hepatology. 2002 Jul;36(1):164-72. DMA8J1G RU http://www.ncbi.nlm.nih.gov/pubmed/12085361 DMA8J1G DI DMA8J1G DMA8J1G DN Rifampin DMA8J1G MI DTUGYRD DMA8J1G MN P-glycoprotein 1 (ABCB1) DMA8J1G MT DTP DMA8J1G MA Substrate DMA8J1G RN Mammalian drug efflux transporters of the ATP binding cassette (ABC) family in multidrug resistance: A review of the past decade. Cancer Lett. 2016 Jan 1;370(1):153-64. DMA8J1G RU http://www.ncbi.nlm.nih.gov/pubmed/26499806 DMEH3O7 DI DMEH3O7 DMEH3O7 DN Rifamycin DMEH3O7 MI TTR6YA2 DMEH3O7 MN Bacterial RNA polymerase sigma factor SigA (Bact sigA) DMEH3O7 MT DTT DMEH3O7 MA Modulator DMEH3O7 RN NCBI report DMEH3O7 RU http://www.ncbi.nlm.nih.gov/Structure/mmdb/mmdbsrv.cgi?uid=4OIR DMEH3O7 DI DMEH3O7 DMEH3O7 DN Rifamycin DMEH3O7 MI TT79JGK DMEH3O7 MN Mycobacterium RNA polymerase (MycB RNAP) DMEH3O7 MT DTT DMEH3O7 MA Inhibitor DMEH3O7 RN Rifamycin action on RNA polymerase in antibiotic-tolerant Mycobacterium tuberculosis results in differentially detectable populations.Proc Natl Acad Sci U S A. 2017 Jun 13;114(24):E4832-E4840. DMEH3O7 RU https://pubmed.ncbi.nlm.nih.gov/28559332 DMEH3O7 DI DMEH3O7 DMEH3O7 DN Rifamycin DMEH3O7 MI TTS31JH DMEH3O7 MN Staphylococcus Plastid RNA polymerase beta (Stap-coc rpoB) DMEH3O7 MT DTT DMEH3O7 MA Modulator DMEH3O7 RN NCBI report DMEH3O7 RU http://www.ncbi.nlm.nih.gov/Structure/mmdb/mmdbsrv.cgi?uid=4OIR DMCHV4I DI DMCHV4I DMCHV4I DN Rifapentine DMCHV4I MI DE4LYSA DMCHV4I MN Cytochrome P450 3A4 (CYP3A4) DMCHV4I MT DME DMCHV4I MA Metabolism DMCHV4I RN Inhibitory potential of twenty five anti-tuberculosis drugs on CYP activities in human liver microsomes. Biol Pharm Bull. 2015;38(9):1425-9. DMCHV4I RU https://www.ncbi.nlm.nih.gov/pubmed/?term=26094899 DMCHV4I DI DMCHV4I DMCHV4I DN Rifapentine DMCHV4I MI TTHKJLN DMCHV4I MN DNA-directed RNA polymerase (RNAP) DMCHV4I MT DTT DMCHV4I MA Binder DMCHV4I RN Contribution of rpoB mutations to development of rifamycin cross-resistance in Mycobacterium tuberculosis. Antimicrob Agents Chemother. 1998 Jul;42(7):1853-7. DMCHV4I RU https://pubmed.ncbi.nlm.nih.gov/9661035 DMW1TV2 DI DMW1TV2 DMW1TV2 DN Rifaximin DMW1TV2 MI DE4LYSA DMW1TV2 MN Cytochrome P450 3A4 (CYP3A4) DMW1TV2 MT DME DMW1TV2 MA Metabolism DMW1TV2 RN Probable interaction between warfarin and rifaximin in a patient treated for small intestine bacterial overgrowth. Ann Pharmacother. 2011 May;45(5):e25. DMW1TV2 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=21505109 DMW1TV2 DI DMW1TV2 DMW1TV2 DN Rifaximin DMW1TV2 MI DTUGYRD DMW1TV2 MN P-glycoprotein 1 (ABCB1) DMW1TV2 MT DTP DMW1TV2 MA Substrate DMW1TV2 RN Advantageous Solubility-Permeability Interplay When Using Amorphous Solid Dispersion (ASD) Formulation for the BCS Class IV P-gp Substrate Rifaximin: Simultaneous Increase of Both the Solubility and the Permeability. AAPS J. 2017 May;19(3):806-813. DMW1TV2 RU http://www.ncbi.nlm.nih.gov/pubmed/28204967 DM13PQW DI DM13PQW DM13PQW DN Rilmenidine DM13PQW MI TT2NUT5 DM13PQW MN Adrenergic receptor alpha-2C (ADRA2C) DM13PQW MT DTT DM13PQW MA Modulator DM13PQW RN Rilmenidine-induced ocular hypotension: role of imidazoline1 and alpha 2 receptors. Curr Eye Res. 1996 Sep;15(9):943-50. DM13PQW RU https://pubmed.ncbi.nlm.nih.gov/8921215 DMGLUQS DI DMGLUQS DMGLUQS DN Rilonacept DMGLUQS MI TTRYK0X DMGLUQS MN Interleukin-1 beta (IL1B) DMGLUQS MT DTT DMGLUQS MA Modulator DMGLUQS RN 2008 FDA drug approvals. Nat Rev Drug Discov. 2009 Feb;8(2):93-6. DMGLUQS RU https://pubmed.ncbi.nlm.nih.gov/19180096 DMJ0QOW DI DMJ0QOW DMJ0QOW DN Rilpivirine DMJ0QOW MI DE4LYSA DMJ0QOW MN Cytochrome P450 3A4 (CYP3A4) DMJ0QOW MT DME DMJ0QOW MA Metabolism DMJ0QOW RN Potential of the novel antiretroviral drug rilpivirine to modulate the expression and function of drug transporters and drug-metabolising enzymes in vitro. Int J Antimicrob Agents. 2013 May;41(5):484-7. DMJ0QOW RU https://www.ncbi.nlm.nih.gov/pubmed/?term=23428312 DMJ0QOW DI DMJ0QOW DMJ0QOW DN Rilpivirine DMJ0QOW MI TT84ETX DMJ0QOW MN Human immunodeficiency virus Reverse transcriptase (HIV RT) DMJ0QOW MT DTT DMJ0QOW MA Inhibitor DMJ0QOW RN Emerging antiviral drugs. Expert Opin Emerg Drugs. 2008 Sep;13(3):393-416. DMJ0QOW RU https://pubmed.ncbi.nlm.nih.gov/18764719 DMJ0QOW DI DMJ0QOW DMJ0QOW DN Rilpivirine DMJ0QOW MI DEGTFWK DMJ0QOW MN Mephenytoin 4-hydroxylase (CYP2C19) DMJ0QOW MT DME DMJ0QOW MA Metabolism DMJ0QOW RN Population pharmacokinetics and pharmacogenetics analysis of rilpivirine in HIV-1-infected individuals. Antimicrob Agents Chemother. 2016 Dec 27;61(1). DMJ0QOW RU https://www.ncbi.nlm.nih.gov/pubmed/?term=27799217 DMJ0QOW DI DMJ0QOW DMJ0QOW DN Rilpivirine DMJ0QOW MI DEYGVN4 DMJ0QOW MN UDP-glucuronosyltransferase 1A1 (UGT1A1) DMJ0QOW MT DME DMJ0QOW MA Metabolism DMJ0QOW RN Human biotransformation of the nonnucleoside reverse transcriptase inhibitor rilpivirine and a cross-species metabolism comparison. Antimicrob Agents Chemother. 2013 Oct;57(10):5067-79. DMJ0QOW RU https://www.ncbi.nlm.nih.gov/pubmed/?term=23917319 DMJ0QOW DI DMJ0QOW DMJ0QOW DN Rilpivirine DMJ0QOW MI DELOY3P DMJ0QOW MN UDP-glucuronosyltransferase 1A4 (UGT1A4) DMJ0QOW MT DME DMJ0QOW MA Metabolism DMJ0QOW RN Human biotransformation of the nonnucleoside reverse transcriptase inhibitor rilpivirine and a cross-species metabolism comparison. Antimicrob Agents Chemother. 2013 Oct;57(10):5067-79. DMJ0QOW RU https://www.ncbi.nlm.nih.gov/pubmed/?term=23917319 DMJ0QOW DI DMJ0QOW DMJ0QOW DN Rilpivirine DMJ0QOW MI TT90XZ8 DMJ0QOW MN Voltage-gated sodium channel alpha Nav1.8 (SCN10A) DMJ0QOW MT DTT DMJ0QOW MA Inhibitor DMJ0QOW RN Structures of muO-conotoxins from Conus marmoreus. I nhibitors of tetrodotoxin (TTX)-sensitive and TTX-resistant sodium channels in mammalian senso... J Biol Chem. 2004 Jun 11;279(24):25774-82. DMJ0QOW RU https://pubmed.ncbi.nlm.nih.gov/15044438 DMECBWN DI DMECBWN DMECBWN DN Riluzole DMECBWN MI DTI7UX6 DMECBWN MN Breast cancer resistance protein (ABCG2) DMECBWN MT DTP DMECBWN MA Substrate DMECBWN RN Interactions between riluzole and ABCG2/BCRP transporter. Neurosci Lett. 2009 Mar 6;452(1):12-6. DMECBWN RU http://www.ncbi.nlm.nih.gov/pubmed/19146924 DMECBWN DI DMECBWN DMECBWN DN Riluzole DMECBWN MI DE6OQ3W DMECBWN MN Cytochrome P450 1A1 (CYP1A1) DMECBWN MT DME DMECBWN MA Metabolism DMECBWN RN Summary of information on human CYP enzymes: human P450 metabolism data. Drug Metab Rev. 2002 Feb-May;34(1-2):83-448. DMECBWN RU https://www.ncbi.nlm.nih.gov/pubmed/?term=11996015 DMECBWN DI DMECBWN DMECBWN DN Riluzole DMECBWN MI DEJGDUW DMECBWN MN Cytochrome P450 1A2 (CYP1A2) DMECBWN MT DME DMECBWN MA Metabolism DMECBWN RN Association between CYP1A2 activity and riluzole clearance in patients with amyotrophic lateral sclerosis. Br J Clin Pharmacol. 2005 Mar;59(3):310-3. DMECBWN RU https://www.ncbi.nlm.nih.gov/pubmed/?term=15752377 DMECBWN DI DMECBWN DMECBWN DN Riluzole DMECBWN MI DEYGVN4 DMECBWN MN UDP-glucuronosyltransferase 1A1 (UGT1A1) DMECBWN MT DME DMECBWN MA Metabolism DMECBWN RN Involvement of human CYP1A isoenzymes in the metabolism and drug interactions of riluzole in vitro. J Pharmacol Exp Ther. 1997 Sep;282(3):1465-72. DMECBWN RU https://www.ncbi.nlm.nih.gov/pubmed/?term=9316860 DMECBWN DI DMECBWN DMECBWN DN Riluzole DMECBWN MI TTN9VTF DMECBWN MN Voltage-gated sodium channel alpha Nav1.9 (SCN11A) DMECBWN MT DTT DMECBWN MA Blocker DMECBWN RN Secondary injury mechanisms of spinal cord trauma: a novel therapeutic approach for the management of secondary pathophysiology with the sodium channel blocker riluzole. Prog Brain Res. 2002;137:177-90. DMECBWN RU https://pubmed.ncbi.nlm.nih.gov/12440368 DM5DWMU DI DM5DWMU DM5DWMU DN Rimantadine DM5DWMU MI TTXT3PU DM5DWMU MN Influenza M2 protein (Influ M) DM5DWMU MT DTT DM5DWMU MA Inhibitor DM5DWMU RN Antiviral resistance of influenza A (H3N2) strains isolated in northern Greece between 2004 and 2007. Euro Surveill. 2009 Jan 29;14(4). pii: 19104. DM5DWMU RU https://pubmed.ncbi.nlm.nih.gov/19215710 DMHOAUG DI DMHOAUG DMHOAUG DN Rimegepant DMHOAUG MI TTY6O0Q DMHOAUG MN Calcitonin gene-related peptide receptor (CGRPR) DMHOAUG MT DTT DMHOAUG MA Antagonist DMHOAUG RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health Human Services. 2020 DMHOAUG RU https://www.accessdata.fda.gov/drugsatfda_docs/label/2020/212728s000lbl.pdf DMTAREC DI DMTAREC DMTAREC DN Rimexolone DMTAREC MI DE4LYSA DMTAREC MN Cytochrome P450 3A4 (CYP3A4) DMTAREC MT DME DMTAREC MA Metabolism DMTAREC RN Identification of clinically used drugs that activate pregnane X receptors. Drug Metab Dispos. 2011 Jan;39(1):151-9. DMTAREC RU https://www.ncbi.nlm.nih.gov/pubmed/?term=20966043 DMTAREC DI DMTAREC DMTAREC DN Rimexolone DMTAREC MI TTPNQAC DMTAREC MN Estrogen-related receptor-alpha (ESRRA) DMTAREC MT DTT DMTAREC MA Modulator DMTAREC RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 622). DMTAREC RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=622 DMA47C6 DI DMA47C6 DMA47C6 DN Rimiterol DMA47C6 MI TTMXGCW DMA47C6 MN Adrenergic receptor beta-3 (ADRB3) DMA47C6 MT DTT DMA47C6 MA Modulator DMA47C6 RN Comparison of the beta2-adrenoceptor selectivity of rimiterol, salbutamol and isoprenaline by the intravenous route in man. Br J Clin Pharmacol. 1975 Feb;2(1):41-8. DMA47C6 RU https://pubmed.ncbi.nlm.nih.gov/10940 DMXBLMP DI DMXBLMP DMXBLMP DN Riociguat DMXBLMP MI DTI7UX6 DMXBLMP MN Breast cancer resistance protein (ABCG2) DMXBLMP MT DTP DMXBLMP MA Substrate DMXBLMP RN KEGG: new perspectives on genomes, pathways, diseases and drugs. Nucleic Acids Res. 2017 Jan 4;45(D1):D353-D361. (dg:DG01913) DMXBLMP RU https://www.kegg.jp/dbget-bin/www_bget?dg:DG01913 DMXBLMP DI DMXBLMP DMXBLMP DN Riociguat DMXBLMP MI DE6OQ3W DMXBLMP MN Cytochrome P450 1A1 (CYP1A1) DMXBLMP MT DME DMXBLMP MA Metabolism DMXBLMP RN Riociguat (adempas): a novel agent for the treatment of pulmonary arterial hypertension and chronic thromboembolic pulmonary hypertension. P T. 2014 Nov;39(11):749-58. DMXBLMP RU https://www.ncbi.nlm.nih.gov/pubmed/?term=25395817 DMXBLMP DI DMXBLMP DMXBLMP DN Riociguat DMXBLMP MI DES5XRU DMXBLMP MN Cytochrome P450 2C8 (CYP2C8) DMXBLMP MT DME DMXBLMP MA Metabolism DMXBLMP RN Riociguat (adempas): a novel agent for the treatment of pulmonary arterial hypertension and chronic thromboembolic pulmonary hypertension. P T. 2014 Nov;39(11):749-58. DMXBLMP RU https://www.ncbi.nlm.nih.gov/pubmed/?term=25395817 DMXBLMP DI DMXBLMP DMXBLMP DN Riociguat DMXBLMP MI DERSX5P DMXBLMP MN Cytochrome P450 2J2 (CYP2J2) DMXBLMP MT DME DMXBLMP MA Metabolism DMXBLMP RN Riociguat (adempas): a novel agent for the treatment of pulmonary arterial hypertension and chronic thromboembolic pulmonary hypertension. P T. 2014 Nov;39(11):749-58. DMXBLMP RU https://www.ncbi.nlm.nih.gov/pubmed/?term=25395817 DMXBLMP DI DMXBLMP DMXBLMP DN Riociguat DMXBLMP MI DE4LYSA DMXBLMP MN Cytochrome P450 3A4 (CYP3A4) DMXBLMP MT DME DMXBLMP MA Metabolism DMXBLMP RN Riociguat (adempas): a novel agent for the treatment of pulmonary arterial hypertension and chronic thromboembolic pulmonary hypertension. P T. 2014 Nov;39(11):749-58. DMXBLMP RU https://www.ncbi.nlm.nih.gov/pubmed/?term=25395817 DMXBLMP DI DMXBLMP DMXBLMP DN Riociguat DMXBLMP MI DTUGYRD DMXBLMP MN P-glycoprotein 1 (ABCB1) DMXBLMP MT DTP DMXBLMP MA Substrate DMXBLMP RN Pharmacokinetic interaction profile of riociguat, a new soluble guanylate cyclase stimulator, initro. Pulm Pharmacol Ther. 2014 Aug;28(2):130-7. DMXBLMP RU http://www.ncbi.nlm.nih.gov/pubmed/24657506 DMXBLMP DI DMXBLMP DMXBLMP DN Riociguat DMXBLMP MI TTWNFC2 DMXBLMP MN Soluble guanylyl cyclase (GUCY2D) DMXBLMP MT DTT DMXBLMP MA Modulator DMXBLMP RN Radium 223 dichloride for prostate cancer treatment. Drug Des Devel Ther. 2017 Sep 6;11:2643-2651. DMXBLMP RU https://pubmed.ncbi.nlm.nih.gov/28919714 DM958QB DI DM958QB DM958QB DN Ripretinib DM958QB MI TT8FYO9 DM958QB MN Platelet-derived growth factor receptor alpha (PDGFRA) DM958QB MT DTT DM958QB MA Inhibitor DM958QB RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health Human Services. 2020 DM958QB RU https://www.accessdata.fda.gov/drugsatfda_docs/label/2020/213973s000lbl.pdf DM958QB DI DM958QB DM958QB DN Ripretinib DM958QB MI TTX41N9 DM958QB MN Tyrosine-protein kinase Kit (KIT) DM958QB MT DTT DM958QB MA Inhibitor DM958QB RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health Human Services. 2020 DM958QB RU https://www.accessdata.fda.gov/drugsatfda_docs/label/2020/213973s000lbl.pdf DMM32GT DI DMM32GT DMM32GT DN Risankizumab DMM32GT MI TTC1GLB DMM32GT MN Interleukin-23 (IL23) DMM32GT MT DTT DMM32GT MA Inhibitor DMM32GT RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health Human Services. 2019 DMM32GT RU https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/761105s000lbl.pdf DMIMF8J DI DMIMF8J DMIMF8J DN Risdiplam DMIMF8J MI DE4LYSA DMIMF8J MN Cytochrome P450 3A4 (CYP3A4) DMIMF8J MT DME DMIMF8J MA Metabolism DMIMF8J RN A phase 1 healthy male volunteer single escalating dose study of the pharmacokinetics and pharmacodynamics of risdiplam (RG7916, RO7034067), a SMN2 splicing modifier. Br J Clin Pharmacol. 2019 Jan;85(1):181-193. DMIMF8J RU https://www.ncbi.nlm.nih.gov/pubmed/?term=30302786 DM5FLTY DI DM5FLTY DM5FLTY DN Risedronate DM5FLTY MI TTIKWV4 DM5FLTY MN Geranyltranstransferase (FDPS) DM5FLTY MT DTT DM5FLTY MA Inhibitor DM5FLTY RN Activity of bisphosphonates against Trypanosoma brucei rhodesiense. J Med Chem. 2002 Jul 4;45(14):2904-14. DM5FLTY RU https://pubmed.ncbi.nlm.nih.gov/12086478 DMN6DXL DI DMN6DXL DMN6DXL DN Risperidone DMN6DXL MI DECB0K3 DMN6DXL MN Cytochrome P450 2D6 (CYP2D6) DMN6DXL MT DME DMN6DXL MA Metabolism DMN6DXL RN Cytochrome P450 3A inhibitor itraconazole affects plasma concentrations of risperidone and 9-hydroxyrisperidone in schizophrenic patients. Clin Pharmacol Ther. 2005 Nov;78(5):520-8. DMN6DXL RU https://www.ncbi.nlm.nih.gov/pubmed/?term=16321618 DMN6DXL DI DMN6DXL DMN6DXL DN Risperidone DMN6DXL MI DE4LYSA DMN6DXL MN Cytochrome P450 3A4 (CYP3A4) DMN6DXL MT DME DMN6DXL MA Metabolism DMN6DXL RN Summary of information on human CYP enzymes: human P450 metabolism data. Drug Metab Rev. 2002 Feb-May;34(1-2):83-448. DMN6DXL RU https://www.ncbi.nlm.nih.gov/pubmed/?term=11996015 DMN6DXL DI DMN6DXL DMN6DXL DN Risperidone DMN6DXL MI DEIBDNY DMN6DXL MN Cytochrome P450 3A5 (CYP3A5) DMN6DXL MT DME DMN6DXL MA Metabolism DMN6DXL RN Different enantioselective 9-hydroxylation of risperidone by the two human CYP2D6 and CYP3A4 enzymes. Drug Metab Dispos. 2001 Oct;29(10):1263-8. DMN6DXL RU https://www.ncbi.nlm.nih.gov/pubmed/?term=11560868 DMN6DXL DI DMN6DXL DMN6DXL DN Risperidone DMN6DXL MI TTEX248 DMN6DXL MN Dopamine D2 receptor (D2R) DMN6DXL MT DTT DMN6DXL MA Antagonist DMN6DXL RN Randomized clinical comparison of perospirone and risperidone in patients with schizophrenia: Kansai Psychiatric Multicenter Study. Psychiatry Clin Neurosci. 2009 Jun;63(3):322-8. DMN6DXL RU https://pubmed.ncbi.nlm.nih.gov/19566763 DMN6DXL DI DMN6DXL DMN6DXL DN Risperidone DMN6DXL MI DTUGYRD DMN6DXL MN P-glycoprotein 1 (ABCB1) DMN6DXL MT DTP DMN6DXL MA Substrate DMN6DXL RN Effect of verapamil on pharmacokinetics and pharmacodynamics of risperidone: in vivo evidence of involvement of P-glycoprotein in risperidone disposition. Clin Pharmacol Ther. 2005 Jul;78(1):43-51. DMN6DXL RU http://www.ncbi.nlm.nih.gov/pubmed/16003291 DM4V6RL DI DM4V6RL DM4V6RL DN Ritodrine DM4V6RL MI TT2CJVK DM4V6RL MN Adrenergic receptor beta-2 (ADRB2) DM4V6RL MT DTT DM4V6RL MA Modulator DM4V6RL RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. DM4V6RL RU https://www.fda.gov/ DM4V6RL DI DM4V6RL DM4V6RL DN Ritodrine DM4V6RL MI DEYWLRK DM4V6RL MN Sulfotransferase 1A1 (SULT1A1) DM4V6RL MT DME DM4V6RL MA Metabolism DM4V6RL RN Inhibitory effects of various beverages on ritodrine sulfation by recombinant human sulfotransferase isoforms SULT1A1 and SULT1A3. Pharm Res. 2005 Aug;22(8):1406-10. DM4V6RL RU https://www.ncbi.nlm.nih.gov/pubmed/?term=16078151 DMU764S DI DMU764S DMU764S DN Ritonavir DMU764S MI DEPKLMQ DMU764S MN Cytochrome P450 2B6 (CYP2B6) DMU764S MT DME DMU764S MA Metabolism DMU764S RN Evaluation of CYP2B6 induction and prediction of clinical drug-drug interactions: considerations from the IQ consortium induction working group-an industry perspective. Drug Metab Dispos. 2016 Oct;44(10):1720-30. DMU764S RU https://www.ncbi.nlm.nih.gov/pubmed/?term=27422672 DMU764S DI DMU764S DMU764S DN Ritonavir DMU764S MI DECB0K3 DMU764S MN Cytochrome P450 2D6 (CYP2D6) DMU764S MT DME DMU764S MA Metabolism DMU764S RN Reversible coma caused by risperidone-ritonavir interaction. Clin Neuropharmacol. 2002 Sep-Oct;25(5):251-3. DMU764S RU https://www.ncbi.nlm.nih.gov/pubmed/?term=12410055 DMU764S DI DMU764S DMU764S DN Ritonavir DMU764S MI DE4LYSA DMU764S MN Cytochrome P450 3A4 (CYP3A4) DMU764S MT DME DMU764S MA Metabolism DMU764S RN Effect of extended exposure to grapefruit juice on cytochrome P450 3A activity in humans: comparison with ritonavir. Clin Pharmacol Ther. 2006 Mar;79(3):243-54. DMU764S RU https://www.ncbi.nlm.nih.gov/pubmed/?term=16513448 DMU764S DI DMU764S DMU764S DN Ritonavir DMU764S MI DEIBDNY DMU764S MN Cytochrome P450 3A5 (CYP3A5) DMU764S MT DME DMU764S MA Metabolism DMU764S RN Drug Interactions Flockhart Table DMU764S RU https://drug-interactions.medicine.iu.edu/Main-Table.aspx DMU764S DI DMU764S DMU764S DN Ritonavir DMU764S MI DERD86B DMU764S MN Cytochrome P450 3A7 (CYP3A7) DMU764S MT DME DMU764S MA Metabolism DMU764S RN Effect of extended exposure to grapefruit juice on cytochrome P450 3A activity in humans: comparison with ritonavir. Clin Pharmacol Ther. 2006 Mar;79(3):243-54. DMU764S RU https://www.ncbi.nlm.nih.gov/pubmed/?term=16513448 DMU764S DI DMU764S DMU764S DN Ritonavir DMU764S MI TT5FNQT DMU764S MN Human immunodeficiency virus Protease (HIV PR) DMU764S MT DTT DMU764S MA Inhibitor DMU764S RN Anti-HIV drugs: 25 compounds approved within 25 years after the discovery of HIV. Int J Antimicrob Agents. 2009 Apr;33(4):307-20. DMU764S RU https://pubmed.ncbi.nlm.nih.gov/19108994 DMU764S DI DMU764S DMU764S DN Ritonavir DMU764S MI DTFI42L DMU764S MN Multidrug resistance-associated protein 2 (ABCC2) DMU764S MT DTP DMU764S MA Substrate DMU764S RN Interaction of eight HIV protease inhibitors with the canalicular efflux transporter ABCC2 (MRP2) in sandwich-cultured rat and human hepatocytes. Biopharm Drug Dispos. 2010 Mar;31(2-3):178-88. DMU764S RU http://www.ncbi.nlm.nih.gov/pubmed/20238377 DMU764S DI DMU764S DMU764S DN Ritonavir DMU764S MI DTPFTEQ DMU764S MN Organic anion transporting polypeptide 2B1 (SLCO2B1) DMU764S MT DTP DMU764S MA Substrate DMU764S RN pH dependence of organic anion-transporting polypeptide 2B1 in Caco-2 cells: potential role in antiretroviral drug oral bioavailability and drug-drug interactions. J Pharmacol Exp Ther. 2010 Sep 1;334(3):1009-22. DMU764S RU http://www.ncbi.nlm.nih.gov/pubmed/20507927 DMU764S DI DMU764S DMU764S DN Ritonavir DMU764S MI DTUGYRD DMU764S MN P-glycoprotein 1 (ABCB1) DMU764S MT DTP DMU764S MA Substrate DMU764S RN MDR1 G1199A polymorphism alters permeability of HIV protease inhibitors across P-glycoprotein-expressing epithelial cells. AIDS. 2005 Oct 14;19(15):1617-25. DMU764S RU http://www.ncbi.nlm.nih.gov/pubmed/16184031 DMBUH26 DI DMBUH26 DMBUH26 DN Rituximab DMBUH26 MI TTUE541 DMBUH26 MN Leukocyte surface antigen Leu-16 (CD20) DMBUH26 MT DTT DMBUH26 RN [Contribution of radioimmunotherapy to the treatment of lymphoma]. Ann Pharm Fr. 2008 Nov-Dec;66(5-6):300-8. DMBUH26 RU https://pubmed.ncbi.nlm.nih.gov/19061730 DM1YVZT DI DM1YVZT DM1YVZT DN Rituximab DM1YVZT MI TTUE541 DM1YVZT MN Leukocyte surface antigen Leu-16 (CD20) DM1YVZT MT DTT DM1YVZT RN Clinical pipeline report, company report or official report of Genentech (2009). DM1YVZT RU http://www.gene.com/gene/pipeline/status/ DMQMBZ1 DI DMQMBZ1 DMQMBZ1 DN Rivaroxaban DMQMBZ1 MI DTI7UX6 DMQMBZ1 MN Breast cancer resistance protein (ABCG2) DMQMBZ1 MT DTP DMQMBZ1 MA Substrate DMQMBZ1 RN Absence of both MDR1 (ABCB1) and breast cancer resistance protein (ABCG2) transporters significantly alters rivaroxaban disposition and central nervous system entry. Basic Clin Pharmacol Toxicol. 2013 Mar;112(3):164-70. DMQMBZ1 RU http://www.ncbi.nlm.nih.gov/pubmed/22958812 DMQMBZ1 DI DMQMBZ1 DMQMBZ1 DN Rivaroxaban DMQMBZ1 MI TTCIHJA DMQMBZ1 MN Coagulation factor Xa (F10) DMQMBZ1 MT DTT DMQMBZ1 MA Modulator DMQMBZ1 RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015 DMQMBZ1 RU https://www.accessdata.fda.gov/scripts/cder/drugsatfda/ DMQMBZ1 DI DMQMBZ1 DMQMBZ1 DN Rivaroxaban DMQMBZ1 MI DERSX5P DMQMBZ1 MN Cytochrome P450 2J2 (CYP2J2) DMQMBZ1 MT DME DMQMBZ1 MA Metabolism DMQMBZ1 RN Comparative efficacy and safety of the novel oral anticoagulants dabigatran, rivaroxaban and apixaban in preclinical and clinical development. Thromb Haemost. 2010 Mar;103(3):572-85. DMQMBZ1 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=20135071 DMQMBZ1 DI DMQMBZ1 DMQMBZ1 DN Rivaroxaban DMQMBZ1 MI DE4LYSA DMQMBZ1 MN Cytochrome P450 3A4 (CYP3A4) DMQMBZ1 MT DME DMQMBZ1 MA Metabolism DMQMBZ1 RN Comparative efficacy and safety of the novel oral anticoagulants dabigatran, rivaroxaban and apixaban in preclinical and clinical development. Thromb Haemost. 2010 Mar;103(3):572-85. DMQMBZ1 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=20135071 DMQMBZ1 DI DMQMBZ1 DMQMBZ1 DN Rivaroxaban DMQMBZ1 MI DEIBDNY DMQMBZ1 MN Cytochrome P450 3A5 (CYP3A5) DMQMBZ1 MT DME DMQMBZ1 MA Metabolism DMQMBZ1 RN Pharmacology of the new target-specific oral anticoagulants. J Thromb Thrombolysis. 2013 Aug;36(2):133-40. DMQMBZ1 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=23645472 DMQMBZ1 DI DMQMBZ1 DMQMBZ1 DN Rivaroxaban DMQMBZ1 MI DTUGYRD DMQMBZ1 MN P-glycoprotein 1 (ABCB1) DMQMBZ1 MT DTP DMQMBZ1 MA Substrate DMQMBZ1 RN Downregulation of ABCB1 gene in patients with total hip or knee arthroplasty influences pharmacokinetics of rivaroxaban: a population pharmacokinetic-pharmacodynamic study. Eur J Clin Pharmacol. 2019 Feb 6. DMQMBZ1 RU http://www.ncbi.nlm.nih.gov/pubmed/30725221 DMG629M DI DMG629M DMG629M DN Rivastigmine DMG629M MI TT1RS9F DMG629M MN Acetylcholinesterase (AChE) DMG629M MT DTT DMG629M MA Modulator DMG629M RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2465). DMG629M RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2465 DMDJMA3 DI DMDJMA3 DMDJMA3 DN Rizatriptan DMDJMA3 MI TT6MSOK DMDJMA3 MN 5-HT 1D receptor (HTR1D) DMDJMA3 MT DTT DMDJMA3 MA Agonist DMDJMA3 RN An introduction to migraine: from ancient treatment to functional pharmacology and antimigraine therapy. Proc West Pharmacol Soc. 2002;45:199-210. DMDJMA3 RU https://pubmed.ncbi.nlm.nih.gov/12434581 DMDJMA3 DI DMDJMA3 DMDJMA3 DN Rizatriptan DMDJMA3 MI DTT79CX DMDJMA3 MN Organic cation transporter 1 (SLC22A1) DMDJMA3 MT DTP DMDJMA3 MA Substrate DMDJMA3 RN OCT1 mediates hepatic uptake of sumatriptan and loss-of-function OCT1 polymorphisms affect sumatriptan pharmacokinetics. Clin Pharmacol Ther. 2016 Jun;99(6):633-41. DMDJMA3 RU http://www.ncbi.nlm.nih.gov/pubmed/26659468 DMY9BMK DI DMY9BMK DMY9BMK DN Rocuronium DMY9BMK MI TTF4E0J DMY9BMK MN Neuronal acetylcholine receptor alpha-2 (CHRNA2) DMY9BMK MT DTT DMY9BMK MA Antagonist DMY9BMK RN Pharmacological characteristics of the inhibition of nondepolarizing neuromuscular blocking agents at human adult muscle nicotinic acetylcholine receptor. Anesthesiology. 2009 Jun;110(6):1244-52. DMY9BMK RU https://pubmed.ncbi.nlm.nih.gov/19417616 DMY9BMK DI DMY9BMK DMY9BMK DN Rocuronium DMY9BMK MI DTE2B1D DMY9BMK MN Organic anion transporting polypeptide 1A2 (SLCO1A2) DMY9BMK MT DTP DMY9BMK MA Substrate DMY9BMK RN Polyspecific organic anion transporting polypeptides mediate hepatic uptake of amphipathic type II organic cations. J Pharmacol Exp Ther. 1999 Oct;291(1):147-52. DMY9BMK RU http://jpet.aspetjournals.org/content/291/1/147.long DMY9BMK DI DMY9BMK DMY9BMK DN Rocuronium DMY9BMK MI DTPFTEQ DMY9BMK MN Organic anion transporting polypeptide 2B1 (SLCO2B1) DMY9BMK MT DTP DMY9BMK MA Substrate DMY9BMK RN Drug Interactions in Infectious Diseases. DMY9BMK RU http://www.springer.com/medicine/internal/book/978-1-61779-212-0 DM3P5DA DI DM3P5DA DM3P5DA DN Rofecoxib DM3P5DA MI DEJGDUW DM3P5DA MN Cytochrome P450 1A2 (CYP1A2) DM3P5DA MT DME DM3P5DA MA Metabolism DM3P5DA RN Rofecoxib is a potent inhibitor of cytochrome P450 1A2: studies with tizanidine and caffeine in healthy subjects. Br J Clin Pharmacol. 2006 Sep;62(3):345-57. DM3P5DA RU https://www.ncbi.nlm.nih.gov/pubmed/?term=16934051 DM3P5DA DI DM3P5DA DM3P5DA DN Rofecoxib DM3P5DA MI DES5XRU DM3P5DA MN Cytochrome P450 2C8 (CYP2C8) DM3P5DA MT DME DM3P5DA MA Metabolism DM3P5DA RN Role of cytochrome P450 2C8 in drug metabolism and interactions. Pharmacol Rev. 2016 Jan;68(1):168-241. DM3P5DA RU https://www.ncbi.nlm.nih.gov/pubmed/?term=26721703 DM3P5DA DI DM3P5DA DM3P5DA DN Rofecoxib DM3P5DA MI DE5IED8 DM3P5DA MN Cytochrome P450 2C9 (CYP2C9) DM3P5DA MT DME DM3P5DA MA Metabolism DM3P5DA RN Impact of CYP2C9 genotype on pharmacokinetics: are all cyclooxygenase inhibitors the same? Drug Metab Dispos. 2005 Nov;33(11):1567-75. DM3P5DA RU https://www.ncbi.nlm.nih.gov/pubmed/?term=16118328 DM3P5DA DI DM3P5DA DM3P5DA DN Rofecoxib DM3P5DA MI DE4LYSA DM3P5DA MN Cytochrome P450 3A4 (CYP3A4) DM3P5DA MT DME DM3P5DA MA Metabolism DM3P5DA RN Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. DM3P5DA RU https://www.ncbi.nlm.nih.gov/pubmed/?term=19515014 DM3P5DA DI DM3P5DA DM3P5DA DN Rofecoxib DM3P5DA MI DE073H6 DM3P5DA MN Prostaglandin G/H synthase 1 (COX-1) DM3P5DA MT DME DM3P5DA MA Metabolism DM3P5DA RN Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. DM3P5DA RU https://www.ncbi.nlm.nih.gov/pubmed/?term=19515014 DM3P5DA DI DM3P5DA DM3P5DA DN Rofecoxib DM3P5DA MI TTVKILB DM3P5DA MN Prostaglandin G/H synthase 2 (COX-2) DM3P5DA MT DTT DM3P5DA MA Inhibitor DM3P5DA RN Privileged structures: a useful concept for the rational design of new lead drug candidates. Mini Rev Med Chem. 2007 Nov;7(11):1108-19. DM3P5DA RU https://pubmed.ncbi.nlm.nih.gov/18045214 DMPGHY8 DI DMPGHY8 DMPGHY8 DN Roflumilast DMPGHY8 MI DEJGDUW DMPGHY8 MN Cytochrome P450 1A2 (CYP1A2) DMPGHY8 MT DME DMPGHY8 MA Metabolism DMPGHY8 RN Effect of steady-state enoxacin on single-dose pharmacokinetics of roflumilast and roflumilast N-oxide. J Clin Pharmacol. 2011 Apr;51(4):586-93. DMPGHY8 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=20466871 DMPGHY8 DI DMPGHY8 DMPGHY8 DN Roflumilast DMPGHY8 MI DE4LYSA DMPGHY8 MN Cytochrome P450 3A4 (CYP3A4) DMPGHY8 MT DME DMPGHY8 MA Metabolism DMPGHY8 RN Effect of steady-state enoxacin on single-dose pharmacokinetics of roflumilast and roflumilast N-oxide. J Clin Pharmacol. 2011 Apr;51(4):586-93. DMPGHY8 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=20466871 DMPGHY8 DI DMPGHY8 DMPGHY8 DN Roflumilast DMPGHY8 MI TTV5CGO DMPGHY8 MN Phosphodiesterase 4 (PDE4) DMPGHY8 MT DTT DMPGHY8 MA Modulator DMPGHY8 RN 2011 FDA drug approvals. Nat Rev Drug Discov. 2012 Feb 1;11(2):91-4. DMPGHY8 RU https://pubmed.ncbi.nlm.nih.gov/22293555 DMCZWOK DI DMCZWOK DMCZWOK DN Rokitamycin DMCZWOK MI DE4LYSA DMCZWOK MN Cytochrome P450 3A4 (CYP3A4) DMCZWOK MT DME DMCZWOK MA Metabolism DMCZWOK RN An in vitro study on the metabolism and possible drug interactions of rokitamycin, a macrolide antibiotic, using human liver microsomes. Drug Metab Dispos. 1999 Jul;27(7):776-85. DMCZWOK RU https://www.ncbi.nlm.nih.gov/pubmed/?term=10383920 DM8XP26 DI DM8XP26 DM8XP26 DN Rolapitant DM8XP26 MI DE4LYSA DM8XP26 MN Cytochrome P450 3A4 (CYP3A4) DM8XP26 MT DME DM8XP26 MA Metabolism DM8XP26 RN Pharmacokinetic interactions of rolapitant with cytochrome P450 3A substrates in healthy subjects. J Clin Pharmacol. 2019 Apr;59(4):488-499. DM8XP26 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=30422319 DM8XP26 DI DM8XP26 DM8XP26 DN Rolapitant DM8XP26 MI TTZPO1L DM8XP26 MN Substance-P receptor (TACR1) DM8XP26 MT DTT DM8XP26 MA Antagonist DM8XP26 RN Netupitant and palonosetron trigger NK1 receptor internalization in NG108-15 cells. Exp Brain Res. 2014 Aug;232(8):2637-44. DM8XP26 RU https://pubmed.ncbi.nlm.nih.gov/24969614 DMBR5Q7 DI DMBR5Q7 DMBR5Q7 DN Rolitetracycline DMBR5Q7 MI TTQ8KVI DMBR5Q7 MN Staphylococcus 30S ribosomal subunit (Stap-coc pbp2) DMBR5Q7 MT DTT DMBR5Q7 MA Binder DMBR5Q7 RN Reversed-phase high-performance liquid chromatography coupled to ultraviolet and electrospray time-of-flight mass spectrometry on-line detection fo... J Chromatogr A. 2008 Jun 27;1195(1-2):107-16. DMBR5Q7 RU https://pubmed.ncbi.nlm.nih.gov/18501371 DMT5GNL DI DMT5GNL DMT5GNL DN Romidepsin DMT5GNL MI DEPKLMQ DMT5GNL MN Cytochrome P450 2B6 (CYP2B6) DMT5GNL MT DME DMT5GNL MA Metabolism DMT5GNL RN FDA Label of Romidepsin. The 2020 official website of the U.S. Food and Drug Administration. DMT5GNL RU https://www.accessdata.fda.gov/drugsatfda_docs/label/2009/022393lbl.pdf DMT5GNL DI DMT5GNL DMT5GNL DN Romidepsin DMT5GNL MI DE4LYSA DMT5GNL MN Cytochrome P450 3A4 (CYP3A4) DMT5GNL MT DME DMT5GNL MA Metabolism DMT5GNL RN A phase I/II trial of the histone deacetylase inhibitor romidepsin for adults with recurrent malignant glioma: North American Brain Tumor Consortium Study 03-03. Neuro Oncol. 2011 May;13(5):509-16. DMT5GNL RU https://www.ncbi.nlm.nih.gov/pubmed/?term=21377994 DMT5GNL DI DMT5GNL DMT5GNL DN Romidepsin DMT5GNL MI DEIBDNY DMT5GNL MN Cytochrome P450 3A5 (CYP3A5) DMT5GNL MT DME DMT5GNL MA Metabolism DMT5GNL RN Population pharmacokinetics of romidepsin in patients with cutaneous T-cell lymphoma and relapsed peripheral T-cell lymphoma. Clin Cancer Res. 2009 Feb 15;15(4):1496-503. DMT5GNL RU https://www.ncbi.nlm.nih.gov/pubmed/?term=19228751 DMT5GNL DI DMT5GNL DMT5GNL DN Romidepsin DMT5GNL MI TT6R7JZ DMT5GNL MN Histone deacetylase 1 (HDAC1) DMT5GNL MT DTT DMT5GNL MA Inhibitor DMT5GNL RN Hughes B: 2009 FDA drug approvals. Nat Rev Drug Discov. 2010 Feb;9(2):89-92. DMT5GNL RU https://pubmed.ncbi.nlm.nih.gov/20118952 DMT5GNL DI DMT5GNL DMT5GNL DN Romidepsin DMT5GNL MI DT9C1TS DMT5GNL MN Organic anion transporting polypeptide 1B3 (SLCO1B3) DMT5GNL MT DTP DMT5GNL MA Substrate DMT5GNL RN Population pharmacokinetics of romidepsin in patients with cutaneous T-cell lymphoma and relapsed peripheral T-cell lymphoma. Clin Cancer Res. 2009 Feb 15;15(4):1496-503. DMT5GNL RU http://www.ncbi.nlm.nih.gov/pubmed/19228751 DMT5GNL DI DMT5GNL DMT5GNL DN Romidepsin DMT5GNL MI DTUGYRD DMT5GNL MN P-glycoprotein 1 (ABCB1) DMT5GNL MT DTP DMT5GNL MA Substrate DMT5GNL RN Population pharmacokinetics of romidepsin in patients with cutaneous T-cell lymphoma and relapsed peripheral T-cell lymphoma. Clin Cancer Res. 2009 Feb 15;15(4):1496-503. DMT5GNL RU http://www.ncbi.nlm.nih.gov/pubmed/19228751 DM3U7SZ DI DM3U7SZ DM3U7SZ DN Romiplostim DM3U7SZ MI TT037IE DM3U7SZ MN Aryl hydrocarbon receptor (AHR) DM3U7SZ MT DTT DM3U7SZ MA Modulator DM3U7SZ RN A Phase I study of the angiogenesis inhibitor SU5416 (semaxanib) in solid tumours, incorporating dynamic contrast MR pharmacodynamic end points. Br J Cancer. 2005 Oct 17;93(8):876-83. DM3U7SZ RU https://pubmed.ncbi.nlm.nih.gov/16222321 DM3U7SZ DI DM3U7SZ DM3U7SZ DN Romiplostim DM3U7SZ MI TTRLW2X DM3U7SZ MN Fibroblast growth factor receptor 1 (FGFR1) DM3U7SZ MT DTT DM3U7SZ MA Inhibitor DM3U7SZ RN Anthranilic acid amides: a novel class of antiangiogenic VEGF receptor kinase inhibitors. J Med Chem. 2002 Dec 19;45(26):5687-93. DM3U7SZ RU https://pubmed.ncbi.nlm.nih.gov/12477352 DM3U7SZ DI DM3U7SZ DM3U7SZ DN Romiplostim DM3U7SZ MI TT8FYO9 DM3U7SZ MN Platelet-derived growth factor receptor alpha (PDGFRA) DM3U7SZ MT DTT DM3U7SZ MA Inhibitor DM3U7SZ RN Discovery of 5-[5-fluoro-2-oxo-1,2- dihydroindol-(3Z)-ylidenemethyl]-2,4- dimethyl-1H-pyrrole-3-carboxylic acid (2-diethylaminoethyl)amide, a novel... J Med Chem. 2003 Mar 27;46(7):1116-9. DM3U7SZ RU https://pubmed.ncbi.nlm.nih.gov/12646019 DM3U7SZ DI DM3U7SZ DM3U7SZ DN Romiplostim DM3U7SZ MI TTI7421 DM3U7SZ MN Platelet-derived growth factor receptor beta (PDGFRB) DM3U7SZ MT DTT DM3U7SZ MA Inhibitor DM3U7SZ RN Discovery of 5-[5-fluoro-2-oxo-1,2- dihydroindol-(3Z)-ylidenemethyl]-2,4- dimethyl-1H-pyrrole-3-carboxylic acid (2-diethylaminoethyl)amide, a novel... J Med Chem. 2003 Mar 27;46(7):1116-9. DM3U7SZ RU https://pubmed.ncbi.nlm.nih.gov/12646019 DM3U7SZ DI DM3U7SZ DM3U7SZ DN Romiplostim DM3U7SZ MI TT4DXQT DM3U7SZ MN Proto-oncogene c-Ret (RET) DM3U7SZ MT DTT DM3U7SZ MA Inhibitor DM3U7SZ RN Synthesis, structure-activity relationship and crystallographic studies of 3-substituted indolin-2-one RET inhibitors. Bioorg Med Chem. 2010 Feb 15;18(4):1482-96. DM3U7SZ RU https://pubmed.ncbi.nlm.nih.gov/20117004 DM3U7SZ DI DM3U7SZ DM3U7SZ DN Romiplostim DM3U7SZ MI TTIHYA4 DM3U7SZ MN Thrombopoietin receptor (MPL) DM3U7SZ MT DTT DM3U7SZ MA Modulator DM3U7SZ RN 2008 FDA drug approvals. Nat Rev Drug Discov. 2009 Feb;8(2):93-6. DM3U7SZ RU https://pubmed.ncbi.nlm.nih.gov/19180096 DM3U7SZ DI DM3U7SZ DM3U7SZ DN Romiplostim DM3U7SZ MI TTX41N9 DM3U7SZ MN Tyrosine-protein kinase Kit (KIT) DM3U7SZ MT DTT DM3U7SZ MA Inhibitor DM3U7SZ RN New anilinophthalazines as potent and orally well absorbed inhibitors of the VEGF receptor tyrosine kinases useful as antagonists of tumor-driven a... J Med Chem. 2000 Jun 15;43(12):2310-23. DM3U7SZ RU https://pubmed.ncbi.nlm.nih.gov/10882357 DM3U7SZ DI DM3U7SZ DM3U7SZ DN Romiplostim DM3U7SZ MI TTUTJGQ DM3U7SZ MN Vascular endothelial growth factor receptor 2 (KDR) DM3U7SZ MT DTT DM3U7SZ MA Inhibitor DM3U7SZ RN Anthranilic acid amides: a novel class of antiangiogenic VEGF receptor kinase inhibitors. J Med Chem. 2002 Dec 19;45(26):5687-93. DM3U7SZ RU https://pubmed.ncbi.nlm.nih.gov/12477352 DM3U7SZ DI DM3U7SZ DM3U7SZ DN Romiplostim DM3U7SZ MI TT1VAUK DM3U7SZ MN VEGFR1 messenger RNA (VEGFR1 mRNA) DM3U7SZ MT DTT DM3U7SZ MA Inhibitor DM3U7SZ RN New anilinophthalazines as potent and orally well absorbed inhibitors of the VEGF receptor tyrosine kinases useful as antagonists of tumor-driven a... J Med Chem. 2000 Jun 15;43(12):2310-23. DM3U7SZ RU https://pubmed.ncbi.nlm.nih.gov/10882357 DMFJZN0 DI DMFJZN0 DMFJZN0 DN Romosozumab DMFJZN0 MI TTYRO4F DMFJZN0 MN Sclerostin (SOST) DMFJZN0 MT DTT DMFJZN0 RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health Human Services. 2019 DMFJZN0 RU https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/761062s000lbl.pdf DMA6S1D DI DMA6S1D DMA6S1D DN Ropinirole DMA6S1D MI DEJGDUW DMA6S1D MN Cytochrome P450 1A2 (CYP1A2) DMA6S1D MT DME DMA6S1D MA Metabolism DMA6S1D RN Receptor-binding and pharmacokinetic properties of dopaminergic agonists. Curr Top Med Chem. 2008;8(12):1049-67. DMA6S1D RU https://www.ncbi.nlm.nih.gov/pubmed/?term=18691132 DMA6S1D DI DMA6S1D DMA6S1D DN Ropinirole DMA6S1D MI DE4LYSA DMA6S1D MN Cytochrome P450 3A4 (CYP3A4) DMA6S1D MT DME DMA6S1D MA Metabolism DMA6S1D RN In vitro identification of the P450 enzymes responsible for the metabolism of ropinirole. Drug Metab Dispos. 1997 Jul;25(7):840-4. DMA6S1D RU https://www.ncbi.nlm.nih.gov/pubmed/?term=9224778 DMA6S1D DI DMA6S1D DMA6S1D DN Ropinirole DMA6S1D MI TTEX248 DMA6S1D MN Dopamine D2 receptor (D2R) DMA6S1D MT DTT DMA6S1D MA Modulator DMA6S1D RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. DMA6S1D RU https://www.fda.gov/ DMA6S1D DI DMA6S1D DMA6S1D DN Ropinirole DMA6S1D MI TT4C8EA DMA6S1D MN Dopamine D3 receptor (D3R) DMA6S1D MT DTT DMA6S1D MA Modulator DMA6S1D RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. DMA6S1D RU https://www.fda.gov/ DMSPJG2 DI DMSPJG2 DMSPJG2 DN Ropivacaine DMSPJG2 MI DEJGDUW DMSPJG2 MN Cytochrome P450 1A2 (CYP1A2) DMSPJG2 MT DME DMSPJG2 MA Metabolism DMSPJG2 RN Metabolism of ropivacaine in humans is mediated by CYP1A2 and to a minor extent by CYP3A4: an interaction study with fluvoxamine and ketoconazole as in vivo inhibitors. Clin Pharmacol Ther. 1998 Nov;64(5):484-91. DMSPJG2 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=9834040 DMSPJG2 DI DMSPJG2 DMSPJG2 DN Ropivacaine DMSPJG2 MI DEPKLMQ DMSPJG2 MN Cytochrome P450 2B6 (CYP2B6) DMSPJG2 MT DME DMSPJG2 MA Metabolism DMSPJG2 RN Summary of information on human CYP enzymes: human P450 metabolism data. 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U.S. Department of Health & Human Services. DMSPJG2 RU https://www.fda.gov/ DMILWZR DI DMILWZR DMILWZR DN Rosiglitazone DMILWZR MI DTI7UX6 DMILWZR MN Breast cancer resistance protein (ABCG2) DMILWZR MT DTP DMILWZR MA Substrate DMILWZR RN ATP-binding cassette transporters in human heart failure. Naunyn Schmiedebergs Arch Pharmacol. 2008 May;377(3):231-43. DMILWZR RU http://www.ncbi.nlm.nih.gov/pubmed/18392808 DMY6EAO DI DMY6EAO DMY6EAO DN Rosiglitazone DMY6EAO MI DES5XRU DMY6EAO MN Cytochrome P450 2C8 (CYP2C8) DMY6EAO MT DME DMY6EAO MA Metabolism DMY6EAO RN Characterization of the cytochrome P450 enzymes involved in the in vitro metabolism of rosiglitazone. Br J Clin Pharmacol. 1999 Sep;48(3):424-32. 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DMY6EAO RU https://www.ncbi.nlm.nih.gov/pubmed/?term=15900286 DMY6EAO DI DMY6EAO DMY6EAO DN Rosiglitazone DMY6EAO MI DE073H6 DMY6EAO MN Prostaglandin G/H synthase 1 (COX-1) DMY6EAO MT DME DMY6EAO MA Metabolism DMY6EAO RN Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. DMY6EAO RU https://www.ncbi.nlm.nih.gov/pubmed/?term=19515014 DMT45MU DI DMT45MU DMT45MU DN Rosiglitazone XR DMT45MU MI TTZMAO3 DMT45MU MN Peroxisome proliferator-activated receptor gamma (PPAR-gamma) DMT45MU MT DTT DMT45MU MA Agonist DMT45MU RN Clinical pipeline report, company report or official report of GlaxoSmithKline (2009). DMT45MU RU http://www.gsk.com/investors/product_pipeline/docs/gsk-pipeline-feb09.pdf DMVOIK1 DI DMVOIK1 DMVOIK1 DN Rosoxacin DMVOIK1 MI TT0IHXV DMVOIK1 MN DNA topoisomerase II (TOP2) DMVOIK1 MT DTT DMVOIK1 MA Inhibitor DMVOIK1 RN Inhibition of Micrococcus luteus DNA gyrase by norfloxacin and 10 other quinolone carboxylic acids. Antimicrob Agents Chemother. 1986 Apr;29(4):598-601. DMVOIK1 RU https://pubmed.ncbi.nlm.nih.gov/3010848 DMMIQ7G DI DMMIQ7G DMMIQ7G DN Rosuvastatin DMMIQ7G MI DTI7UX6 DMMIQ7G MN Breast cancer resistance protein (ABCG2) DMMIQ7G MT DTP DMMIQ7G MA Substrate DMMIQ7G RN Involvement of multiple transporters in the hepatobiliary transport of rosuvastatin. Drug Metab Dispos. 2008 Oct;36(10):2014-23. DMMIQ7G RU http://www.ncbi.nlm.nih.gov/pubmed/18617601 DMMIQ7G DI DMMIQ7G DMMIQ7G DN Rosuvastatin DMMIQ7G MI DE9QHP6 DMMIQ7G MN Cytochrome P450 1B1 (CYP1B1) DMMIQ7G MT DME DMMIQ7G MA Metabolism DMMIQ7G RN Pharmacokinetics of rosuvastatin when coadministered with rifampicin in healthy males: a randomized, single-blind, placebo-controlled, crossover study. Clin Ther. 2008 Jul;30(7):1283-9. DMMIQ7G RU https://www.ncbi.nlm.nih.gov/pubmed/?term=18691987 DMMIQ7G DI DMMIQ7G DMMIQ7G DN Rosuvastatin DMMIQ7G MI DE5IED8 DMMIQ7G MN Cytochrome P450 2C9 (CYP2C9) DMMIQ7G MT DME DMMIQ7G MA Metabolism DMMIQ7G RN Effects of acid and lactone forms of eight HMG-CoA reductase inhibitors on CYP-mediated metabolism and MDR1-mediated transport. Pharm Res. 2006 Mar;23(3):506-12. DMMIQ7G RU https://www.ncbi.nlm.nih.gov/pubmed/?term=16388406 DMMIQ7G DI DMMIQ7G DMMIQ7G DN Rosuvastatin DMMIQ7G MI DE4LYSA DMMIQ7G MN Cytochrome P450 3A4 (CYP3A4) DMMIQ7G MT DME DMMIQ7G MA Metabolism DMMIQ7G RN Effects of acid and lactone forms of eight HMG-CoA reductase inhibitors on CYP-mediated metabolism and MDR1-mediated transport. Pharm Res. 2006 Mar;23(3):506-12. DMMIQ7G RU https://www.ncbi.nlm.nih.gov/pubmed/?term=16388406 DMMIQ7G DI DMMIQ7G DMMIQ7G DN Rosuvastatin DMMIQ7G MI TTPADOQ DMMIQ7G MN HMG-CoA reductase (HMGCR) DMMIQ7G MT DTT DMMIQ7G MA Inhibitor DMMIQ7G RN New dimension of statin action on ApoB atherogenicity. Clin Cardiol. 2003 Jan;26(1 Suppl 1):I7-10. DMMIQ7G RU https://pubmed.ncbi.nlm.nih.gov/12539816 DMMIQ7G DI DMMIQ7G DMMIQ7G DN Rosuvastatin DMMIQ7G MI DTFI42L DMMIQ7G MN Multidrug resistance-associated protein 2 (ABCC2) DMMIQ7G MT DTP DMMIQ7G MA Substrate DMMIQ7G RN Involvement of multiple transporters in the hepatobiliary transport of rosuvastatin. Drug Metab Dispos. 2008 Oct;36(10):2014-23. DMMIQ7G RU http://www.ncbi.nlm.nih.gov/pubmed/18617601 DMMIQ7G DI DMMIQ7G DMMIQ7G DN Rosuvastatin DMMIQ7G MI DTVP67E DMMIQ7G MN Organic anion transporter 3 (SLC22A8) DMMIQ7G MT DTP DMMIQ7G MA Substrate DMMIQ7G RN The contribution of organic anion transporters OAT1 and OAT3 to the renal uptake of rosuvastatin. J Pharmacol Exp Ther. 2007 Sep;322(3):1221-7. DMMIQ7G RU http://www.ncbi.nlm.nih.gov/pubmed/17585018 DMMIQ7G DI DMMIQ7G DMMIQ7G DN Rosuvastatin DMMIQ7G MI DTE2B1D DMMIQ7G MN Organic anion transporting polypeptide 1A2 (SLCO1A2) DMMIQ7G MT DTP DMMIQ7G MA Substrate DMMIQ7G RN Drug and bile acid transporters in rosuvastatin hepatic uptake: function, expression, and pharmacogenetics. Gastroenterology. 2006 May;130(6):1793-806. DMMIQ7G RU http://www.ncbi.nlm.nih.gov/pubmed/16697742 DMMIQ7G DI DMMIQ7G DMMIQ7G DN Rosuvastatin DMMIQ7G MI DT3D8F0 DMMIQ7G MN Organic anion transporting polypeptide 1B1 (SLCO1B1) DMMIQ7G MT DTP DMMIQ7G MA Substrate DMMIQ7G RN Involvement of multiple transporters in the hepatobiliary transport of rosuvastatin. Drug Metab Dispos. 2008 Oct;36(10):2014-23. DMMIQ7G RU http://www.ncbi.nlm.nih.gov/pubmed/18617601 DMMIQ7G DI DMMIQ7G DMMIQ7G DN Rosuvastatin DMMIQ7G MI DT9C1TS DMMIQ7G MN Organic anion transporting polypeptide 1B3 (SLCO1B3) DMMIQ7G MT DTP DMMIQ7G MA Substrate DMMIQ7G RN Involvement of multiple transporters in the hepatobiliary transport of rosuvastatin. Drug Metab Dispos. 2008 Oct;36(10):2014-23. DMMIQ7G RU http://www.ncbi.nlm.nih.gov/pubmed/18617601 DMMIQ7G DI DMMIQ7G DMMIQ7G DN Rosuvastatin DMMIQ7G MI DTPFTEQ DMMIQ7G MN Organic anion transporting polypeptide 2B1 (SLCO2B1) DMMIQ7G MT DTP DMMIQ7G MA Substrate DMMIQ7G RN Involvement of multiple transporters in the hepatobiliary transport of rosuvastatin. Drug Metab Dispos. 2008 Oct;36(10):2014-23. DMMIQ7G RU http://www.ncbi.nlm.nih.gov/pubmed/18617601 DMMIQ7G DI DMMIQ7G DMMIQ7G DN Rosuvastatin DMMIQ7G MI DTUGYRD DMMIQ7G MN P-glycoprotein 1 (ABCB1) DMMIQ7G MT DTP DMMIQ7G MA Substrate DMMIQ7G RN Involvement of multiple transporters in the hepatobiliary transport of rosuvastatin. Drug Metab Dispos. 2008 Oct;36(10):2014-23. DMMIQ7G RU http://www.ncbi.nlm.nih.gov/pubmed/18617601 DMMIQ7G DI DMMIQ7G DMMIQ7G DN Rosuvastatin DMMIQ7G MI DT56EKP DMMIQ7G MN Sodium/taurocholate cotransporting polypeptide (SLC10A1) DMMIQ7G MT DTP DMMIQ7G MA Substrate DMMIQ7G RN Drug and bile acid transporters in rosuvastatin hepatic uptake: function, expression, and pharmacogenetics. Gastroenterology. 2006 May;130(6):1793-806. DMMIQ7G RU http://www.ncbi.nlm.nih.gov/pubmed/16697742 DMP7X6Q DI DMP7X6Q DMP7X6Q DN Rotigotine DMP7X6Q MI DE4LYSA DMP7X6Q MN Cytochrome P450 3A4 (CYP3A4) DMP7X6Q MT DME DMP7X6Q MA Metabolism DMP7X6Q RN Receptor-binding and pharmacokinetic properties of dopaminergic agonists. Curr Top Med Chem. 2008;8(12):1049-67. DMP7X6Q RU https://www.ncbi.nlm.nih.gov/pubmed/?term=18691132 DMP7X6Q DI DMP7X6Q DMP7X6Q DN Rotigotine DMP7X6Q MI DEYWLRK DMP7X6Q MN Sulfotransferase 1A1 (SULT1A1) DMP7X6Q MT DME DMP7X6Q MA Metabolism DMP7X6Q RN Identification of the human SULT enzymes involved in the metabolism of rotigotine. 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DMP7X6Q RU https://www.ncbi.nlm.nih.gov/pubmed/?term=26465778 DMP7X6Q DI DMP7X6Q DMP7X6Q DN Rotigotine DMP7X6Q MI DED5UR3 DMP7X6Q MN Sulfotransferase 1B1 (SULT1B1) DMP7X6Q MT DME DMP7X6Q MA Metabolism DMP7X6Q RN Identification of the human SULT enzymes involved in the metabolism of rotigotine. J Clin Pharmacol. 2016 Jun;56(6):754-60. DMP7X6Q RU https://www.ncbi.nlm.nih.gov/pubmed/?term=26465778 DMP7X6Q DI DMP7X6Q DMP7X6Q DN Rotigotine DMP7X6Q MI DEU3DHN DMP7X6Q MN Sulfotransferase 1C4 (SULT1C4) DMP7X6Q MT DME DMP7X6Q MA Metabolism DMP7X6Q RN Identification of the human SULT enzymes involved in the metabolism of rotigotine. J Clin Pharmacol. 2016 Jun;56(6):754-60. DMP7X6Q RU https://www.ncbi.nlm.nih.gov/pubmed/?term=26465778 DMP7X6Q DI DMP7X6Q DMP7X6Q DN Rotigotine DMP7X6Q MI DESTKG6 DMP7X6Q MN Sulfotransferase 1E1 (SULT1E1) DMP7X6Q MT DME DMP7X6Q MA Metabolism DMP7X6Q RN Identification of the human SULT enzymes involved in the metabolism of rotigotine. J Clin Pharmacol. 2016 Jun;56(6):754-60. DMP7X6Q RU https://www.ncbi.nlm.nih.gov/pubmed/?term=26465778 DM9PVX8 DI DM9PVX8 DM9PVX8 DN Rucaparib DM9PVX8 MI DEJGDUW DM9PVX8 MN Cytochrome P450 1A2 (CYP1A2) DM9PVX8 MT DME DM9PVX8 MA Metabolism DM9PVX8 RN Rucaparib: the past, present, and future of a newly approved PARP inhibitor for ovarian cancer. Onco Targets Ther. 2017 Jun 19;10:3029-3037. DM9PVX8 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=28790837 DM9PVX8 DI DM9PVX8 DM9PVX8 DN Rucaparib DM9PVX8 MI TTEBCY8 DM9PVX8 MN Poly [ADP-ribose] polymerase (PARP) DM9PVX8 MT DTT DM9PVX8 MA Modulator DM9PVX8 RN 2016 FDA drug approvals. Nat Rev Drug Discov. 2017 Feb 2;16(2):73-76. DM9PVX8 RU https://www.ncbi.nlm.nih.gov/pubmed/28148938 DMWE60C DI DMWE60C DMWE60C DN Rufinamide DMWE60C MI DEB30C5 DMWE60C MN Carboxylesterase 1 (CES1) DMWE60C MT DME DMWE60C MA Metabolism DMWE60C RN Investigation of the metabolism of rufinamide and its interaction with valproate. Drug Metab Lett. 2011 Dec;5(4):280-9. DMWE60C RU https://www.ncbi.nlm.nih.gov/pubmed/?term=22022867 DMWE60C DI DMWE60C DMWE60C DN Rufinamide DMWE60C MI DETHCPD DMWE60C MN Carboxylesterase 2 (CES2) DMWE60C MT DME DMWE60C MA Metabolism DMWE60C RN Investigation of the metabolism of rufinamide and its interaction with valproate. Drug Metab Lett. 2011 Dec;5(4):280-9. DMWE60C RU https://www.ncbi.nlm.nih.gov/pubmed/?term=22022867 DMWE60C DI DMWE60C DMWE60C DN Rufinamide DMWE60C MI TTRK8B9 DMWE60C MN Sodium channel unspecific (NaC) DMWE60C MT DTT DMWE60C MA Blocker DMWE60C RN Emerging drugs for epilepsy. Expert Opin Emerg Drugs. 2007 Sep;12(3):407-22. DMWE60C RU https://pubmed.ncbi.nlm.nih.gov/17874969 DM7Q98D DI DM7Q98D DM7Q98D DN Ruxolitinib DM7Q98D MI TT6DM01 DM7Q98D MN Janus kinase 1 (JAK-1) DM7Q98D MT DTT DM7Q98D MA Modulator DM7Q98D RN 2011 FDA drug approvals. Nat Rev Drug Discov. 2012 Feb 1;11(2):91-4. 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The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1800). DMOFP18 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1800 DM0YWJC DI DM0YWJC DM0YWJC DN Safinamide DM0YWJC MI TTGP7BY DM0YWJC MN Monoamine oxidase type B (MAO-B) DM0YWJC MT DTT DM0YWJC MA Inhibitor DM0YWJC RN Emerging drugs for epilepsy. Expert Opin Emerg Drugs. 2007 Sep;12(3):407-22. DM0YWJC RU https://pubmed.ncbi.nlm.nih.gov/17874969 DM0J2ZT DI DM0J2ZT DM0J2ZT DN Safinamide mesylate DM0J2ZT MI DE4LYSA DM0J2ZT MN Cytochrome P450 3A4 (CYP3A4) DM0J2ZT MT DME DM0J2ZT MA Metabolism DM0J2ZT RN Disposition and metabolism of safinamide, a novel drug for Parkinson's disease, in healthy male volunteers. Pharmacology. 2013;92(3-4):207-16. DM0J2ZT RU https://www.ncbi.nlm.nih.gov/pubmed/?term=24136086 DM0J2ZT DI DM0J2ZT DM0J2ZT DN Safinamide mesylate DM0J2ZT MI DERE4TU DM0J2ZT MN Monoamine oxidase type A (MAO-A) DM0J2ZT MT DME DM0J2ZT MA Metabolism DM0J2ZT RN Solid-phase synthesis and insights into structure-activity relationships of safinamide analogues as potent and selective inhibitors of type B monoamine oxidase. J Med Chem. 2007 Oct 4;50(20):4909-16. DM0J2ZT RU https://www.ncbi.nlm.nih.gov/pubmed/?term=17824599 DM0J2ZT DI DM0J2ZT DM0J2ZT DN Safinamide mesylate DM0J2ZT MI TTGP7BY DM0J2ZT MN Monoamine oxidase type B (MAO-B) DM0J2ZT MT DTT DM0J2ZT MA Inhibitor DM0J2ZT RN 2017 FDA drug approvals.Nat Rev Drug Discov. 2018 Feb;17(2):81-85. DM0J2ZT RU https://pubmed.ncbi.nlm.nih.gov/29348678 DMN9CWF DI DMN9CWF DMN9CWF DN Salbutamol DMN9CWF MI TT2CJVK DMN9CWF MN Adrenergic receptor beta-2 (ADRB2) DMN9CWF MT DTT DMN9CWF MA Agonist DMN9CWF RN Potential of beta2-adrenoceptor agonists as add-on therapy for multiple sclerosis: focus on salbutamol (albuterol). CNS Drugs. 2002;16(1):1-8. DMN9CWF RU https://pubmed.ncbi.nlm.nih.gov/11772115 DMN9CWF DI DMN9CWF DMN9CWF DN Salbutamol DMN9CWF MI DEB30C5 DMN9CWF MN Carboxylesterase 1 (CES1) DMN9CWF MT DME DMN9CWF MA Metabolism DMN9CWF RN Effect of carboxylesterase 1 c.428G>A single nucleotide variation on the pharmacokinetics of quinapril and enalapril. Br J Clin Pharmacol. 2015 Nov;80(5):1131-8. DMN9CWF RU https://www.ncbi.nlm.nih.gov/pubmed/?term=25919042 DMN9CWF DI DMN9CWF DMN9CWF DN Salbutamol DMN9CWF MI DE4LYSA DMN9CWF MN Cytochrome P450 3A4 (CYP3A4) DMN9CWF MT DME DMN9CWF MA Metabolism DMN9CWF RN Summary of information on human CYP enzymes: human P450 metabolism data. Drug Metab Rev. 2002 Feb-May;34(1-2):83-448. DMN9CWF RU https://www.ncbi.nlm.nih.gov/pubmed/?term=11996015 DMN9CWF DI DMN9CWF DMN9CWF DN Salbutamol DMN9CWF MI DTT79CX DMN9CWF MN Organic cation transporter 1 (SLC22A1) DMN9CWF MT DTP DMN9CWF MA Substrate DMN9CWF RN Identification of novel substrates and structure-activity relationship of cellular uptake mediated by human organic cation transporters 1 and 2. J Med Chem. 2013 Sep 26;56(18):7232-42. DMN9CWF RU http://www.ncbi.nlm.nih.gov/pubmed/23984907 DMN9CWF DI DMN9CWF DMN9CWF DN Salbutamol DMN9CWF MI DEP7E8X DMN9CWF MN Sulfotransferase 1A3 (SULT1A3) DMN9CWF MT DME DMN9CWF MA Metabolism DMN9CWF RN SULT 1A3 single-nucleotide polymorphism and the single dose pharmacokinetics of inhaled salbutamol enantiomers: are some athletes at risk of higher urine levels? Drug Test Anal. 2015 Feb;7(2):109-13. DMN9CWF RU https://www.ncbi.nlm.nih.gov/pubmed/?term=24692077 DM1T2LS DI DM1T2LS DM1T2LS DN Salicin DM1T2LS MI DEFKVZD DM1T2LS MN Phospho-beta-glucosidase (LBA1706) DM1T2LS MT DME DM1T2LS MA Metabolism DM1T2LS RN Microbial unmasking of plant glycosides. mBio. 2018 Jan 30;9(1). pii: e02433-17. DM1T2LS RU https://pubmed.ncbi.nlm.nih.gov/29382739 DM2F8XZ DI DM2F8XZ DM2F8XZ DN Salicyclic acid DM2F8XZ MI TTUNARX DM2F8XZ MN Carbonic anhydrase (CA) DM2F8XZ MT DTT DM2F8XZ MA Inhibitor DM2F8XZ RN Carbonic anhydrase inhibitors: Inhibition of the new membrane-associated isoform XV with phenols. Bioorg Med Chem Lett. 2008 Jun 15;18(12):3593-6. DM2F8XZ RU https://pubmed.ncbi.nlm.nih.gov/18501600 DM2F8XZ DI DM2F8XZ DM2F8XZ DN Salicyclic acid DM2F8XZ MI TTHQPL7 DM2F8XZ MN Carbonic anhydrase I (CA-I) DM2F8XZ MT DTT DM2F8XZ MA Inhibitor DM2F8XZ RN Carbonic anhydrase inhibitors: inhibition of mammalian isoforms I-XIV with a series of substituted phenols including paracetamol and salicylic acid. Bioorg Med Chem. 2008 Aug 1;16(15):7424-8. DM2F8XZ RU https://pubmed.ncbi.nlm.nih.gov/18579385 DM2F8XZ DI DM2F8XZ DM2F8XZ DN Salicyclic acid DM2F8XZ MI TTANPDJ DM2F8XZ MN Carbonic anhydrase II (CA-II) DM2F8XZ MT DTT DM2F8XZ MA Inhibitor DM2F8XZ RN Carbonic anhydrase inhibitors: inhibition of mammalian isoforms I-XIV with a series of substituted phenols including paracetamol and salicylic acid. Bioorg Med Chem. 2008 Aug 1;16(15):7424-8. DM2F8XZ RU https://pubmed.ncbi.nlm.nih.gov/18579385 DM2F8XZ DI DM2F8XZ DM2F8XZ DN Salicyclic acid DM2F8XZ MI TTZHA0O DM2F8XZ MN Carbonic anhydrase IV (CA-IV) DM2F8XZ MT DTT DM2F8XZ MA Inhibitor DM2F8XZ RN Carbonic anhydrase inhibitors: inhibition of mammalian isoforms I-XIV with a series of substituted phenols including paracetamol and salicylic acid. Bioorg Med Chem. 2008 Aug 1;16(15):7424-8. DM2F8XZ RU https://pubmed.ncbi.nlm.nih.gov/18579385 DM2F8XZ DI DM2F8XZ DM2F8XZ DN Salicyclic acid DM2F8XZ MI TTCFSPE DM2F8XZ MN Carbonic anhydrase VI (CA-VI) DM2F8XZ MT DTT DM2F8XZ MA Inhibitor DM2F8XZ RN Carbonic anhydrase inhibitors: inhibition of mammalian isoforms I-XIV with a series of substituted phenols including paracetamol and salicylic acid. Bioorg Med Chem. 2008 Aug 1;16(15):7424-8. DM2F8XZ RU https://pubmed.ncbi.nlm.nih.gov/18579385 DM2F8XZ DI DM2F8XZ DM2F8XZ DN Salicyclic acid DM2F8XZ MI TTSYM0R DM2F8XZ MN Carbonic anhydrase XII (CA-XII) DM2F8XZ MT DTT DM2F8XZ MA Inhibitor DM2F8XZ RN Carbonic anhydrase inhibitors: inhibition of mammalian isoforms I-XIV with a series of substituted phenols including paracetamol and salicylic acid. Bioorg Med Chem. 2008 Aug 1;16(15):7424-8. DM2F8XZ RU https://pubmed.ncbi.nlm.nih.gov/18579385 DM2F8XZ DI DM2F8XZ DM2F8XZ DN Salicyclic acid DM2F8XZ MI DE5IED8 DM2F8XZ MN Cytochrome P450 2C9 (CYP2C9) DM2F8XZ MT DME DM2F8XZ MA Metabolism DM2F8XZ RN Aromatic hydroxylation of salicylic acid and aspirin by human cytochromes P450. Eur J Pharm Sci. 2015 Jun 20;73:49-56. DM2F8XZ RU https://www.ncbi.nlm.nih.gov/pubmed/?term=25840124 DM2F8XZ DI DM2F8XZ DM2F8XZ DN Salicyclic acid DM2F8XZ MI DT342ZG DM2F8XZ MN Monocarboxylate transporter 1 (SLC16A1) DM2F8XZ MT DTP DM2F8XZ MA Substrate DM2F8XZ RN H+-coupled nutrient, micronutrient and drug transporters in the mammalian small intestine. Exp Physiol. 2007 Jul;92(4):603-19. DM2F8XZ RU https://doi.org/10.1113/expphysiol.2005.029959 DM2F8XZ DI DM2F8XZ DM2F8XZ DN Salicyclic acid DM2F8XZ MI DTLT3UG DM2F8XZ MN Monocarboxylate transporter 2 (SLC16A7) DM2F8XZ MT DTP DM2F8XZ MA Substrate DM2F8XZ RN Clinical and Functional Relevance of the Monocarboxylate Transporter Family in Disease Pathophysiology and Drug Therapy. Clin Transl Sci. 2018 Jul;11(4):352-364. DM2F8XZ RU http://www.ncbi.nlm.nih.gov/pubmed/29660777 DM2F8XZ DI DM2F8XZ DM2F8XZ DN Salicyclic acid DM2F8XZ MI DTHE530 DM2F8XZ MN Probable small intestine urate exporter (SLC17A4) DM2F8XZ MT DTP DM2F8XZ MA Substrate DM2F8XZ RN A Na+-phosphate cotransporter homologue (SLC17A4 protein) is an intestinal organic anion exporter. Am J Physiol Cell Physiol. 2012 Jun 1;302(11):C1652-60. DM2F8XZ RU http://www.ncbi.nlm.nih.gov/pubmed/22460716 DM2F8XZ DI DM2F8XZ DM2F8XZ DN Salicyclic acid DM2F8XZ MI TT8NGED DM2F8XZ MN Prostaglandin G/H synthase 1 (COX-1) DM2F8XZ MT DTT DM2F8XZ MA Inhibitor DM2F8XZ RN The C50T polymorphism of the cyclooxygenase-1 gene and the risk of thrombotic events during low-dose therapy with acetyl salicylic acid. Thromb Haemost. 2008 Jul;100(1):70-5. DM2F8XZ RU https://pubmed.ncbi.nlm.nih.gov/18612540 DM2F8XZ DI DM2F8XZ DM2F8XZ DN Salicyclic acid DM2F8XZ MI DTM301H DM2F8XZ MN Sodium-coupled monocarboxylate transporter 2 (SLC5A12) DM2F8XZ MT DTP DM2F8XZ MA Substrate DM2F8XZ RN Sodium-coupled monocarboxylate transporters in normal tissues and in cancer. AAPS J. 2008;10(1):193-9. DM2F8XZ RU http://www.ncbi.nlm.nih.gov/pubmed/18446519 DMIEU69 DI DMIEU69 DMIEU69 DN Salmeterol DMIEU69 MI TT2CJVK DMIEU69 MN Adrenergic receptor beta-2 (ADRB2) DMIEU69 MT DTT DMIEU69 MA Agonist DMIEU69 RN Pharmacogenetic tests in asthma therapy. Clin Lab Med. 2008 Dec;28(4):645-65. DMIEU69 RU https://pubmed.ncbi.nlm.nih.gov/19059068 DMIEU69 DI DMIEU69 DMIEU69 DN Salmeterol DMIEU69 MI DE4LYSA DMIEU69 MN Cytochrome P450 3A4 (CYP3A4) DMIEU69 MT DME DMIEU69 MA Metabolism DMIEU69 RN Clinical pharmacokinetics of salmeterol. Clin Pharmacokinet. 2002;41(1):19-30. DMIEU69 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=11825095 DMIEU69 DI DMIEU69 DMIEU69 DN Salmeterol DMIEU69 MI DEIBDNY DMIEU69 MN Cytochrome P450 3A5 (CYP3A5) DMIEU69 MT DME DMIEU69 MA Metabolism DMIEU69 RN Drug Interactions Flockhart Table DMIEU69 RU https://drug-interactions.medicine.iu.edu/Main-Table.aspx DMIEU69 DI DMIEU69 DMIEU69 DN Salmeterol DMIEU69 MI DERD86B DMIEU69 MN Cytochrome P450 3A7 (CYP3A7) DMIEU69 MT DME DMIEU69 MA Metabolism DMIEU69 RN Drug Interactions Flockhart Table DMIEU69 RU https://drug-interactions.medicine.iu.edu/Main-Table.aspx DMEWUPF DI DMEWUPF DMEWUPF DN Salmon Calcitonin DMEWUPF MI TTLWS2O DMEWUPF MN Calcitonin receptor (CALCR) DMEWUPF MT DTT DMEWUPF MA Binder DMEWUPF RN Improved absorption of salmon calcitonin by ultraflexible liposomes through intranasal delivery. Peptides. 2009 Jul;30(7):1288-95. DMEWUPF RU https://pubmed.ncbi.nlm.nih.gov/19540427 DM13P4C DI DM13P4C DM13P4C DN Salsalate DM13P4C MI TT8NGED DM13P4C MN Prostaglandin G/H synthase 1 (COX-1) DM13P4C MT DTT DM13P4C MA Inhibitor DM13P4C RN New non-steroidal anti-rheumatic drugs: selective inhibitors of inducible cyclooxygenase. Med Klin (Munich). 1998 Jul 15;93(7):407-15. DM13P4C RU https://pubmed.ncbi.nlm.nih.gov/9711054 DM62MUZ DI DM62MUZ DM62MUZ DN Samarium Sm-153 Lexidronam Pentasodium DM62MUZ MI TTGXKP7 DM62MUZ MN Samarium (SAM) DM62MUZ MT DTT DM62MUZ MA Modulator DM62MUZ RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. DM62MUZ RU https://www.fda.gov/ DMDINFS DI DMDINFS DMDINFS DN Sanguinarine DMDINFS MI TTQ38E9 DMDINFS MN Sodium/potassium-transporting ATPase (SPT ATPase) DMDINFS MT DTT DMDINFS MA Modulator DMDINFS RN Medicinal plants in therapy. Bull World Health Organ. 1985;63(6):965-81. DMDINFS RU https://pubmed.ncbi.nlm.nih.gov/3879679 DM5VP0F DI DM5VP0F DM5VP0F DN Saphris DM5VP0F MI DTUGYRD DM5VP0F MN P-glycoprotein 1 (ABCB1) DM5VP0F MT DTP DM5VP0F MA Substrate DM5VP0F RN Human intestinal transporter database: QSAR modeling and virtual profiling of drug uptake, efflux and interactions. Pharm Res. 2013 Apr;30(4):996-1007. DM5VP0F RU https://doi.org/10.1007/s11095-012-0935-x DM4087K DI DM4087K DM4087K DN Saprisartan DM4087K MI TT8DBY3 DM4087K MN Angiotensin II receptor type-1 (AGTR1) DM4087K MT DTT DM4087K MA Antagonist DM4087K RN Pharmacological properties of angiotensin II receptor antagonists. Can J Cardiol. 1999 Nov;15 Suppl F:26F-8F. DM4087K RU https://pubmed.ncbi.nlm.nih.gov/10579749 DM90TJP DI DM90TJP DM90TJP DN Sapropterin hydrochloride DM90TJP MI TTGSVH2 DM90TJP MN Phenylalanine hydroxylase (PAH) DM90TJP MT DTT DM90TJP MA Modulator DM90TJP RN 2007 FDA drug approvals: a year of flux. Nat Rev Drug Discov. 2008 Feb;7(2):107-9. DM90TJP RU https://pubmed.ncbi.nlm.nih.gov/18246607 DMG814N DI DMG814N DMG814N DN Saquinavir DMG814N MI DTI7UX6 DMG814N MN Breast cancer resistance protein (ABCG2) DMG814N MT DTP DMG814N MA Substrate DMG814N RN Nicotine and cotinine increases the brain penetration of saquinavir in rat. J Neurochem. 2010 Dec;115(6):1495-507. DMG814N RU http://www.ncbi.nlm.nih.gov/pubmed/20950334 DMG814N DI DMG814N DMG814N DN Saquinavir DMG814N MI DECB0K3 DMG814N MN Cytochrome P450 2D6 (CYP2D6) DMG814N MT DME DMG814N MA Metabolism DMG814N RN Inhibition of desipramine hydroxylation (Cytochrome P450-2D6) in vitro by quinidine and by viral protease inhibitors: relation to drug interactions in vivo. J Pharm Sci. 1998 Oct;87(10):1184-9. DMG814N RU https://www.ncbi.nlm.nih.gov/pubmed/?term=9758674 DMG814N DI DMG814N DMG814N DN Saquinavir DMG814N MI DE4LYSA DMG814N MN Cytochrome P450 3A4 (CYP3A4) DMG814N MT DME DMG814N MA Metabolism DMG814N RN Effect of saquinavir-ritonavir on cytochrome P450 3A4 activity in healthy volunteers using midazolam as a probe. Pharmacotherapy. 2009 Oct;29(10):1175-81. DMG814N RU https://www.ncbi.nlm.nih.gov/pubmed/?term=19792991 DMG814N DI DMG814N DMG814N DN Saquinavir DMG814N MI DEIBDNY DMG814N MN Cytochrome P450 3A5 (CYP3A5) DMG814N MT DME DMG814N MA Metabolism DMG814N RN Differential inhibition of cytochrome P450 3A4, 3A5 and 3A7 by five human immunodeficiency virus (HIV) protease inhibitors in vitro. Basic Clin Pharmacol Toxicol. 2006 Jan;98(1):79-85. DMG814N RU https://www.ncbi.nlm.nih.gov/pubmed/?term=16433896 DMG814N DI DMG814N DMG814N DN Saquinavir DMG814N MI DERD86B DMG814N MN Cytochrome P450 3A7 (CYP3A7) DMG814N MT DME DMG814N MA Metabolism DMG814N RN Differential inhibition of cytochrome P450 3A4, 3A5 and 3A7 by five human immunodeficiency virus (HIV) protease inhibitors in vitro. Basic Clin Pharmacol Toxicol. 2006 Jan;98(1):79-85. DMG814N RU https://www.ncbi.nlm.nih.gov/pubmed/?term=16433896 DMG814N DI DMG814N DMG814N DN Saquinavir DMG814N MI TT5FNQT DMG814N MN Human immunodeficiency virus Protease (HIV PR) DMG814N MT DTT DMG814N MA Inhibitor DMG814N RN PL-100, a novel HIV-1 protease inhibitor displaying a high genetic barrier to resistance: an in vitro selection study. J Med Virol. 2008 Dec;80(12):2053-63. DMG814N RU https://pubmed.ncbi.nlm.nih.gov/19040279 DMG814N DI DMG814N DMG814N DN Saquinavir DMG814N MI DTSYQGK DMG814N MN Multidrug resistance-associated protein 1 (ABCC1) DMG814N MT DTP DMG814N MA Substrate DMG814N RN Direct evidence that saquinavir is transported by multidrug resistance-associated protein (MRP1) and canalicular multispecific organic anion transporter (MRP2). Antimicrob Agents Chemother. 2002 Nov;46(11):3456-62. DMG814N RU http://www.ncbi.nlm.nih.gov/pubmed/12384350 DMG814N DI DMG814N DMG814N DN Saquinavir DMG814N MI DTFI42L DMG814N MN Multidrug resistance-associated protein 2 (ABCC2) DMG814N MT DTP DMG814N MA Substrate DMG814N RN Evidence for two interacting ligand binding sites in human multidrug resistance protein 2 (ATP binding cassette C2). J Biol Chem. 2003 Jun 27;278(26):23538-44. DMG814N RU http://www.ncbi.nlm.nih.gov/pubmed/12702717 DMG814N DI DMG814N DMG814N DN Saquinavir DMG814N MI DTE2B1D DMG814N MN Organic anion transporting polypeptide 1A2 (SLCO1A2) DMG814N MT DTP DMG814N MA Substrate DMG814N RN Human organic anion-transporting polypeptide OATP-A (SLC21A3) acts in concert with P-glycoprotein and multidrug resistance protein 2 in the vectorial transport of Saquinavir in Hep G2 cells. Mol Pharm. 2004 Jan 12;1(1):49-56. DMG814N RU http://www.ncbi.nlm.nih.gov/pubmed/15832500 DMG814N DI DMG814N DMG814N DN Saquinavir DMG814N MI DT3D8F0 DMG814N MN Organic anion transporting polypeptide 1B1 (SLCO1B1) DMG814N MT DTP DMG814N MA Substrate DMG814N RN Organic anion transporting polypeptide 1B1: a genetically polymorphic transporter of major importance for hepatic drug uptake. Pharmacol Rev. 2011 Mar;63(1):157-81. DMG814N RU http://www.ncbi.nlm.nih.gov/pubmed/21245207 DMG814N DI DMG814N DMG814N DN Saquinavir DMG814N MI DTUGYRD DMG814N MN P-glycoprotein 1 (ABCB1) DMG814N MT DTP DMG814N MA Substrate DMG814N RN Predicting P-glycoprotein effects on oral absorption: correlation of transport in Caco-2 with drug pharmacokinetics in wild-type and mdr1a(-/-) mice in vivo. Pharm Res. 2004 May;21(5):819-26. DMG814N RU http://www.ncbi.nlm.nih.gov/pubmed/15180340 DMKS1DV DI DMKS1DV DMKS1DV DN SARALASIN DMKS1DV MI TT8DBY3 DMKS1DV MN Angiotensin II receptor type-1 (AGTR1) DMKS1DV MT DTT DMKS1DV MA Inhibitor DMKS1DV RN Identification of a potent, selective, and orally active leukotriene a4 hydrolase inhibitor with anti-inflammatory activity. J Med Chem. 2008 Jul 24;51(14):4150-69. DMKS1DV RU https://pubmed.ncbi.nlm.nih.gov/18588282 DMKS1DV DI DMKS1DV DMKS1DV DN SARALASIN DMKS1DV MI TTQVOEI DMKS1DV MN Angiotensin II receptor type-2 (AGTR2) DMKS1DV MT DTT DMKS1DV MA Inhibitor DMKS1DV RN cis-4-(Piperazin-1-yl)-5,6,7a,8,9,10,11,11a-octahydrobenzofuro[2,3-h]quinazolin-2-amine (A-987306), a new histamine H4R antagonist that blocks pain... J Med Chem. 2008 Nov 27;51(22):7094-8. DMKS1DV RU https://pubmed.ncbi.nlm.nih.gov/18983139 DMKZROL DI DMKZROL DMKZROL DN Saralasin Acetate DMKZROL MI TT8DBY3 DMKZROL MN Angiotensin II receptor type-1 (AGTR1) DMKZROL MT DTT DMKZROL MA Modulator DMKZROL RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. DMKZROL RU https://www.fda.gov/ DMLZNIQ DI DMLZNIQ DMLZNIQ DN Sarecycline DMLZNIQ MI TTOVFH2 DMLZNIQ MN Bacterial 30S ribosomal RNA (Bact 30S rRNA) DMLZNIQ MT DTT DMLZNIQ MA Inhibitor DMLZNIQ RN Microbiological Profile of Sarecycline, a Novel Targeted Spectrum Tetracycline for the Treatment of Acne Vulgaris.Antimicrob Agents Chemother. 2018 Dec 21;63(1). pii: e01297-18. DMLZNIQ RU https://pubmed.ncbi.nlm.nih.gov/30397052 DMY0M8J DI DMY0M8J DMY0M8J DN Sargramostim DMY0M8J MI TT6MP2Z DMY0M8J MN GMCSFR-alpha (CSF2RA) DMY0M8J MT DTT DMY0M8J MA Binder DMY0M8J RN Stem cell transplantation and hematopoietic growth factors. Curr Hematol Rep. 2002 Nov;1(2):103-9. DMY0M8J RU https://pubmed.ncbi.nlm.nih.gov/12901131 DMOGNXY DI DMOGNXY DMOGNXY DN Sarilumab DMOGNXY MI TT0E5SK DMOGNXY MN Interleukin 6 receptor (IL6R) DMOGNXY MT DTT DMOGNXY MA Modulator DMOGNXY RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. DMOGNXY RU https://www.fda.gov/ DMGLP6S DI DMGLP6S DMGLP6S DN Sarpogrelate DMGLP6S MI TTJQOD7 DMGLP6S MN 5-HT 2A receptor (HTR2A) DMGLP6S MT DTT DMGLP6S MA Antagonist DMGLP6S RN Beneficial effects of sarpogrelate hydrochloride, a 5-HT2A receptor antagonist, supplemented with pioglitazone on diabetic model mice. Endocr Res. 2009;34(1-2):18-30. DMGLP6S RU https://pubmed.ncbi.nlm.nih.gov/19557588 DMRSKMZ DI DMRSKMZ DMRSKMZ DN Satumomab Pendetide DMRSKMZ MI TTX35ZM DMRSKMZ MN Tumor-associated glycoprotein 72 (TAG-72) DMRSKMZ MT DTT DMRSKMZ MA Binder DMRSKMZ RN Indium-111 satumomab pendetide: the first FDA-approved monoclonal antibody for tumor imaging. J Nucl Med Technol. 1998 Sep;26(3):155-63; quiz 170-1. DMRSKMZ RU https://pubmed.ncbi.nlm.nih.gov/9755434 DMGXENV DI DMGXENV DMGXENV DN Saxagliptin DMGXENV MI DE4LYSA DMGXENV MN Cytochrome P450 3A4 (CYP3A4) DMGXENV MT DME DMGXENV MA Metabolism DMGXENV RN Effect of rifampicin on the pharmacokinetics and pharmacodynamics of saxagliptin, a dipeptidyl peptidase-4 inhibitor, in healthy subjects. Br J Clin Pharmacol. 2011 Jul;72(1):92-102. DMGXENV RU https://www.ncbi.nlm.nih.gov/pubmed/?term=21651615 DMGXENV DI DMGXENV DMGXENV DN Saxagliptin DMGXENV MI DEIBDNY DMGXENV MN Cytochrome P450 3A5 (CYP3A5) DMGXENV MT DME DMGXENV MA Metabolism DMGXENV RN Effect of rifampicin on the pharmacokinetics and pharmacodynamics of saxagliptin, a dipeptidyl peptidase-4 inhibitor, in healthy subjects. Br J Clin Pharmacol. 2011 Jul;72(1):92-102. DMGXENV RU https://www.ncbi.nlm.nih.gov/pubmed/?term=21651615 DMGXENV DI DMGXENV DMGXENV DN Saxagliptin DMGXENV MI TTDIGC1 DMGXENV MN Dipeptidyl peptidase 4 (DPP-4) DMGXENV MT DTT DMGXENV MA Inhibitor DMGXENV RN Hughes B: 2009 FDA drug approvals. Nat Rev Drug Discov. 2010 Feb;9(2):89-92. DMGXENV RU https://pubmed.ncbi.nlm.nih.gov/20118952 DMGXENV DI DMGXENV DMGXENV DN Saxagliptin DMGXENV MI DTSYQGK DMGXENV MN Multidrug resistance-associated protein 1 (ABCC1) DMGXENV MT DTP DMGXENV MA Substrate DMGXENV RN Dipeptidylpeptidase-4 inhibitors (gliptins): focus on drug-drug interactions. Clin Pharmacokinet. 2010 Sep;49(9):573-88. DMGXENV RU http://www.ncbi.nlm.nih.gov/pubmed/20690781 DMGXENV DI DMGXENV DMGXENV DN Saxagliptin DMGXENV MI DTVP67E DMGXENV MN Organic anion transporter 3 (SLC22A8) DMGXENV MT DTP DMGXENV MA Substrate DMGXENV RN Comparative clinical pharmacokinetics of dipeptidyl peptidase-4 inhibitors. Clin Pharmacokinet. 2012 Aug 1;51(8):501-14. DMGXENV RU http://www.ncbi.nlm.nih.gov/pubmed/22686547 DMGXENV DI DMGXENV DMGXENV DN Saxagliptin DMGXENV MI DTY0QMU DMGXENV MN Organic anion transporting polypeptide 4C1 (SLCO4C1) DMGXENV MT DTP DMGXENV MA Substrate DMGXENV RN Comparative clinical pharmacokinetics of dipeptidyl peptidase-4 inhibitors. Clin Pharmacokinet. 2012 Aug 1;51(8):501-14. DMGXENV RU http://www.ncbi.nlm.nih.gov/pubmed/22686547 DMGXENV DI DMGXENV DMGXENV DN Saxagliptin DMGXENV MI DTUGYRD DMGXENV MN P-glycoprotein 1 (ABCB1) DMGXENV MT DTP DMGXENV MA Substrate DMGXENV RN Tarascon Pocket Pharmacopoeia 2018 Classic Shirt-Pocket Edition. DMGXENV RU https://books.google.com/books?id=0gBRDwAAQBAJ&pg=PP37&lpg=PP37&dq=Methylergonovine+transporter+uptake+efflex&source=bl&ots=cUTe_ppsmZ&sig=ACfU3U3E_YqrDg0CNEuj8K-7lci47HAnrg&hl=zh-CN&sa=X&ved=2ahUKEwjnj-Dk7d7iAhUsK6YKHd5DBDkQ6AEwEnoECAgQAQ#v=onepage&q&f=false DMDK7T9 DI DMDK7T9 DMDK7T9 DN SBC-102 DMDK7T9 MI TTS8T1M DMDK7T9 MN Lysosomal acid lipase (LIPA) DMDK7T9 MT DTT DMDK7T9 MA Modulator DMDK7T9 RN A Phase 3 Trial of Sebelipase Alfa in Lysosomal Acid Lipase Deficiency. N Engl J Med. 2015 Sep 10;373(11):1010-20. DMDK7T9 RU https://pubmed.ncbi.nlm.nih.gov/26352813 DMOM8AL DI DMOM8AL DMOM8AL DN Scopolamine DMOM8AL MI TTOXS3C DMOM8AL MN Muscarinic acetylcholine receptor (CHRM) DMOM8AL MT DTT DMOM8AL MA Antagonist DMOM8AL RN The amygdala modulates morphine-induced state-dependent memory retrieval via muscarinic acetylcholine receptors. Neuroscience. 2009 May 5;160(2):255-63. DMOM8AL RU https://pubmed.ncbi.nlm.nih.gov/19272427 DMJ18YL DI DMJ18YL DMJ18YL DN Secnidazole DMJ18YL MI DEAN5EW DMJ18YL MN Nitroreductase (NTR) DMJ18YL MT DME DMJ18YL MA Metabolism DMJ18YL RN Overexpression, isotopic labeling, and spectral characterization of Enterobacter cloacae nitroreductase. Protein Expr Purif. 1998 Jun;13(1):53-60. DMJ18YL RU https://pubmed.ncbi.nlm.nih.gov/9631515 DM14RF5 DI DM14RF5 DM14RF5 DN Secobarbital DM14RF5 MI TT1MPAY DM14RF5 MN GABA(A) receptor alpha-1 (GABRA1) DM14RF5 MT DTT DM14RF5 MA Antagonist DM14RF5 RN DrugBank: a knowledgebase for drugs, drug actions and drug targets. Nucleic Acids Res. 2008 Jan;36(Database issue):D901-6. DM14RF5 RU https://pubmed.ncbi.nlm.nih.gov/18048412 DMDKE4N DI DMDKE4N DMDKE4N DN Secretin DMDKE4N MI TTOBVIN DMDKE4N MN Secretin receptor (SCT) DMDKE4N MT DTT DMDKE4N MA Binder DMDKE4N RN False-positive secretin stimulation test for gastrinoma associated with the use of proton pump inhibitor therapy. Clin Gastroenterol Hepatol. 2009 May;7(5):600-2. DMDKE4N RU https://pubmed.ncbi.nlm.nih.gov/19245850 DMFEGB0 DI DMFEGB0 DMFEGB0 DN Segesterone acetate; ethinyl estradiol DMFEGB0 MI TTDSB34 DMFEGB0 MN G-protein coupled estrogen receptor 1 (GPER1) DMFEGB0 MT DTT DMFEGB0 MA Modulator DMFEGB0 RN 2018 FDA drug approvals.Nat Rev Drug Discov. 2019 Feb;18(2):85-89. DMFEGB0 RU https://pubmed.ncbi.nlm.nih.gov/30710142 DMFEGB0 DI DMFEGB0 DMFEGB0 DN Segesterone acetate; ethinyl estradiol DMFEGB0 MI TTUV8G9 DMFEGB0 MN Progesterone receptor (PGR) DMFEGB0 MT DTT DMFEGB0 MA Modulator DMFEGB0 RN 2018 FDA drug approvals.Nat Rev Drug Discov. 2019 Feb;18(2):85-89. DMFEGB0 RU https://pubmed.ncbi.nlm.nih.gov/30710142 DM6034S DI DM6034S DM6034S DN Selegiline DM6034S MI TT32XQJ DM6034S MN Monoamine oxidase (MAO) DM6034S MT DTT DM6034S MA Inhibitor DM6034S RN Novel monoamine oxidase inhibitors: a patent review (2012 - 2014).Expert Opin Ther Pat. 2015 Jan;25(1):91-110. DM6034S RU https://www.ncbi.nlm.nih.gov/pubmed/25399762 DM6034S DI DM6034S DM6034S DN Selegiline DM6034S MI TTGP7BY DM6034S MN Monoamine oxidase type B (MAO-B) DM6034S MT DTT DM6034S MA Inhibitor DM6034S RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2490). DM6034S RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2490 DM6034S DI DM6034S DM6034S DN Selegiline DM6034S MI TTZPO1L DM6034S MN Substance-P receptor (TACR1) DM6034S MT DTT DM6034S MA Antagonist DM6034S RN Clinical pipeline report, company report or official report of GlaxoSmithKline (2009). DM6034S RU http://www.gsk.com/investors/product_pipeline/docs/gsk-pipeline-feb09.pdf DM3VR1L DI DM3VR1L DM3VR1L DN Selegiline hydrochloride DM3VR1L MI DEJGDUW DM3VR1L MN Cytochrome P450 1A2 (CYP1A2) DM3VR1L MT DME DM3VR1L MA Metabolism DM3VR1L RN Comparative studies on the cytochrome p450-associated metabolism and interaction potential of selegiline between human liver-derived in vitro systems. Drug Metab Dispos. 2003 Sep;31(9):1093-102. DM3VR1L RU https://www.ncbi.nlm.nih.gov/pubmed/?term=12920164 DM3VR1L DI DM3VR1L DM3VR1L DN Selegiline hydrochloride DM3VR1L MI DEJVYAZ DM3VR1L MN Cytochrome P450 2A6 (CYP2A6) DM3VR1L MT DME DM3VR1L MA Metabolism DM3VR1L RN Variation in CYP2A6 activity and personalized medicine. J Pers Med. 2017 Dec 1;7(4). pii: E18. DM3VR1L RU https://www.ncbi.nlm.nih.gov/pubmed/?term=29194389 DM3VR1L DI DM3VR1L DM3VR1L DN Selegiline hydrochloride DM3VR1L MI DEPKLMQ DM3VR1L MN Cytochrome P450 2B6 (CYP2B6) DM3VR1L MT DME DM3VR1L MA Metabolism DM3VR1L RN Evaluation of metabolism dependent inhibition of CYP2B6 mediated bupropion hydroxylation in human liver microsomes by monoamine oxidase inhibitors and prediction of potential as perpetrators of drug interaction. Chem Biol Interact. 2015 Mar 25;230:9-20. DM3VR1L RU https://www.ncbi.nlm.nih.gov/pubmed/?term=25656918 DM3VR1L DI DM3VR1L DM3VR1L DN Selegiline hydrochloride DM3VR1L MI DES5XRU DM3VR1L MN Cytochrome P450 2C8 (CYP2C8) DM3VR1L MT DME DM3VR1L MA Metabolism DM3VR1L RN Comparative studies on the cytochrome p450-associated metabolism and interaction potential of selegiline between human liver-derived in vitro systems. Drug Metab Dispos. 2003 Sep;31(9):1093-102. DM3VR1L RU https://www.ncbi.nlm.nih.gov/pubmed/?term=12920164 DM3VR1L DI DM3VR1L DM3VR1L DN Selegiline hydrochloride DM3VR1L MI DE5IED8 DM3VR1L MN Cytochrome P450 2C9 (CYP2C9) DM3VR1L MT DME DM3VR1L MA Metabolism DM3VR1L RN Summary of information on human CYP enzymes: human P450 metabolism data. Drug Metab Rev. 2002 Feb-May;34(1-2):83-448. DM3VR1L RU https://www.ncbi.nlm.nih.gov/pubmed/?term=11996015 DM3VR1L DI DM3VR1L DM3VR1L DN Selegiline hydrochloride DM3VR1L MI DECB0K3 DM3VR1L MN Cytochrome P450 2D6 (CYP2D6) DM3VR1L MT DME DM3VR1L MA Metabolism DM3VR1L RN Inter- and intraindividual pharmacokinetic variations in the treatment of Parkinson's disease. Rinsho Shinkeigaku. 2005 Nov;45(11):895-8. DM3VR1L RU https://www.ncbi.nlm.nih.gov/pubmed/?term=16447756 DM3VR1L DI DM3VR1L DM3VR1L DN Selegiline hydrochloride DM3VR1L MI DE4LYSA DM3VR1L MN Cytochrome P450 3A4 (CYP3A4) DM3VR1L MT DME DM3VR1L MA Metabolism DM3VR1L RN P450 phenotyping of the metabolism of selegiline to desmethylselegiline and methamphetamine. Drug Metab Pharmacokinet. 2007 Apr;22(2):78-87. DM3VR1L RU https://www.ncbi.nlm.nih.gov/pubmed/?term=17495414 DM3VR1L DI DM3VR1L DM3VR1L DN Selegiline hydrochloride DM3VR1L MI DEGTFWK DM3VR1L MN Mephenytoin 4-hydroxylase (CYP2C19) DM3VR1L MT DME DM3VR1L MA Metabolism DM3VR1L RN Comparative studies on the cytochrome p450-associated metabolism and interaction potential of selegiline between human liver-derived in vitro systems. Drug Metab Dispos. 2003 Sep;31(9):1093-102. DM3VR1L RU https://www.ncbi.nlm.nih.gov/pubmed/?term=12920164 DM3VR1L DI DM3VR1L DM3VR1L DN Selegiline hydrochloride DM3VR1L MI TTGP7BY DM3VR1L MN Monoamine oxidase type B (MAO-B) DM3VR1L MT DTT DM3VR1L MA Modulator DM3VR1L RN Emerging drugs for Parkinson's disease. Expert Opin Emerg Drugs. 2006 Sep;11(3):403-17. DM3VR1L RU https://pubmed.ncbi.nlm.nih.gov/16939381 DM25CGV DI DM25CGV DM25CGV DN Selenium DM25CGV MI DEGDPL2 DM25CGV MN Glutathione reductase (GSR) DM25CGV MT DME DM25CGV MA Metabolism DM25CGV RN Selenium metabolism, selenoproteins and mechanisms of cancer prevention: complexities with thioredoxin reductase. Carcinogenesis. 1999 Sep;20(9):1657-66. DM25CGV RU https://www.ncbi.nlm.nih.gov/pubmed/?term=10469608 DM25CGV DI DM25CGV DM25CGV DN Selenium DM25CGV MI DEH4TD6 DM25CGV MN Selenocysteine lyase (SCLY) DM25CGV MT DME DM25CGV MA Metabolism DM25CGV RN Selenium metabolism, selenoproteins and mechanisms of cancer prevention: complexities with thioredoxin reductase. Carcinogenesis. 1999 Sep;20(9):1657-66. DM25CGV RU https://www.ncbi.nlm.nih.gov/pubmed/?term=10469608 DM25CGV DI DM25CGV DM25CGV DN Selenium DM25CGV MI DEUP4DA DM25CGV MN Thioredoxin reductase TR1 (TXNRD1) DM25CGV MT DME DM25CGV MA Metabolism DM25CGV RN Selenium metabolism, selenoproteins and mechanisms of cancer prevention: complexities with thioredoxin reductase. Carcinogenesis. 1999 Sep;20(9):1657-66. DM25CGV RU https://www.ncbi.nlm.nih.gov/pubmed/?term=10469608 DMAHSU0 DI DMAHSU0 DMAHSU0 DN Selexipag DMAHSU0 MI DES5XRU DMAHSU0 MN Cytochrome P450 2C8 (CYP2C8) DMAHSU0 MT DME DMAHSU0 MA Metabolism DMAHSU0 RN FDA Label of Uptravi. The 2020 official website of the U.S. Food and Drug Administration. DMAHSU0 RU https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/207947s005lbl.pdf DMAHSU0 DI DMAHSU0 DMAHSU0 DN Selexipag DMAHSU0 MI TTOFYT1 DMAHSU0 MN Prostacyclin receptor (PTGIR) DMAHSU0 MT DTT DMAHSU0 MA Agonist DMAHSU0 RN Selexipag: an oral, selective prostacyclin receptor agonist for the treatment of pulmonary arterial hypertension. Eur Respir J. 2012 Oct;40(4):874-80. DMAHSU0 RU https://pubmed.ncbi.nlm.nih.gov/22362844 DMZR15V DI DMZR15V DMZR15V DN Selpercatinib DMZR15V MI TT4DXQT DMZR15V MN Proto-oncogene c-Ret (RET) DMZR15V MT DTT DMZR15V MA Inhibitor DMZR15V RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health Human Services. 2020 DMZR15V RU https://www.accessdata.fda.gov/drugsatfda_docs/label/2020/213246s000lbl.pdf DMAGFOD DI DMAGFOD DMAGFOD DN Semaglutide DMAGFOD MI DEKZQY6 DMAGFOD MN Dipeptidyl peptidase IV (DPP4) DMAGFOD MT DME DMAGFOD MA Metabolism DMAGFOD RN Absorption, metabolism and excretion of the GLP-1 analogue semaglutide in humans and nonclinical species. Eur J Pharm Sci. 2017 Jun 15;104:31-41. DMAGFOD RU https://www.ncbi.nlm.nih.gov/pubmed/?term=28323117 DMAGFOD DI DMAGFOD DMAGFOD DN Semaglutide DMAGFOD MI TTVIMDE DMAGFOD MN Glucagon-like peptide 1 receptor (GLP1R) DMAGFOD MT DTT DMAGFOD MA Agonist DMAGFOD RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 249). DMAGFOD RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=249 DMAGFOD DI DMAGFOD DMAGFOD DN Semaglutide DMAGFOD MI DEVN830 DMAGFOD MN Neprilysin (MME) DMAGFOD MT DME DMAGFOD MA Metabolism DMAGFOD RN Absorption, metabolism and excretion of the GLP-1 analogue semaglutide in humans and nonclinical species. Eur J Pharm Sci. 2017 Jun 15;104:31-41. DMAGFOD RU https://www.ncbi.nlm.nih.gov/pubmed/?term=28323117 DM25HP1 DI DM25HP1 DM25HP1 DN Sermorelin DM25HP1 MI TTG4R8V DM25HP1 MN Growth hormone-releasing hormone receptor (GHRHR) DM25HP1 MT DTT DM25HP1 MA Binder DM25HP1 RN Sermorelin: a better approach to management of adult-onset growth hormone insufficiency Clin Interv Aging. 2006;1(4):307-8. DM25HP1 RU https://pubmed.ncbi.nlm.nih.gov/18046908 DM1A9XO DI DM1A9XO DM1A9XO DN Sertaconazole DM1A9XO MI TTTSOUD DM1A9XO MN Candida Cytochrome P450 51 (Candi ERG11) DM1A9XO MT DTT DM1A9XO MA Inhibitor DM1A9XO RN Sertaconazole: a review of its use in the management of superficial mycoses in dermatology and gynaecology. Drugs. 2009;69(3):339-59. DM1A9XO RU https://pubmed.ncbi.nlm.nih.gov/19275277 DM0FB1J DI DM0FB1J DM0FB1J DN Sertraline DM0FB1J MI DEJGDUW DM0FB1J MN Cytochrome P450 1A2 (CYP1A2) DM0FB1J MT DME DM0FB1J MA Metabolism DM0FB1J RN The selective serotonin reuptake inhibitor sertraline: its profile and use in psychiatric disorders. CNS Drug Rev. 2001 Spring;7(1):1-24. DM0FB1J RU https://www.ncbi.nlm.nih.gov/pubmed/?term=11420570 DM0FB1J DI DM0FB1J DM0FB1J DN Sertraline DM0FB1J MI DEPKLMQ DM0FB1J MN Cytochrome P450 2B6 (CYP2B6) DM0FB1J MT DME DM0FB1J MA Metabolism DM0FB1J RN Influence of CYP2B6 and CYP2C19 polymorphisms on sertraline metabolism in major depression patients. Int J Clin Pharm. 2016 Apr;38(2):388-94. DM0FB1J RU https://www.ncbi.nlm.nih.gov/pubmed/?term=26830411 DM0FB1J DI DM0FB1J DM0FB1J DN Sertraline DM0FB1J MI DE5IED8 DM0FB1J MN Cytochrome P450 2C9 (CYP2C9) DM0FB1J MT DME DM0FB1J MA Metabolism DM0FB1J RN Sertraline is metabolized by multiple cytochrome P450 enzymes, monoamine oxidases, and glucuronyl transferases in human: an in vitro study. Drug Metab Dispos. 2005 Feb;33(2):262-70. DM0FB1J RU https://www.ncbi.nlm.nih.gov/pubmed/?term=15547048 DM0FB1J DI DM0FB1J DM0FB1J DN Sertraline DM0FB1J MI DECB0K3 DM0FB1J MN Cytochrome P450 2D6 (CYP2D6) DM0FB1J MT DME DM0FB1J MA Metabolism DM0FB1J RN Some aspects of genetic polymorphism in the biotransformation of antidepressants. Therapie. 2004 Jan-Feb;59(1):5-12. DM0FB1J RU https://www.ncbi.nlm.nih.gov/pubmed/?term=15199661 DM0FB1J DI DM0FB1J DM0FB1J DN Sertraline DM0FB1J MI DEVDYN7 DM0FB1J MN Cytochrome P450 2E1 (CYP2E1) DM0FB1J MT DME DM0FB1J MA Metabolism DM0FB1J RN PharmGKB: A worldwide resource for pharmacogenomic information. Wiley Interdiscip Rev Syst Biol Med. 2018 Jul;10(4):e1417. (ID: PA166181117) DM0FB1J RU https://www.pharmgkb.org/pathway/PA166181117 DM0FB1J DI DM0FB1J DM0FB1J DN Sertraline DM0FB1J MI DE4LYSA DM0FB1J MN Cytochrome P450 3A4 (CYP3A4) DM0FB1J MT DME DM0FB1J MA Metabolism DM0FB1J RN New orally active anticoagulant agents for the prevention and treatment of venous thromboembolism in cancer patients. Ther Clin Risk Manag. 2014 Jun 13;10:423-36. DM0FB1J RU https://www.ncbi.nlm.nih.gov/pubmed/?term=24966680 DM0FB1J DI DM0FB1J DM0FB1J DN Sertraline DM0FB1J MI DEGTFWK DM0FB1J MN Mephenytoin 4-hydroxylase (CYP2C19) DM0FB1J MT DME DM0FB1J MA Metabolism DM0FB1J RN Influence of CYP2B6 and CYP2C19 polymorphisms on sertraline metabolism in major depression patients. Int J Clin Pharm. 2016 Apr;38(2):388-94. DM0FB1J RU https://www.ncbi.nlm.nih.gov/pubmed/?term=26830411 DM0FB1J DI DM0FB1J DM0FB1J DN Sertraline DM0FB1J MI DTUGYRD DM0FB1J MN P-glycoprotein 1 (ABCB1) DM0FB1J MT DTP DM0FB1J MA Substrate DM0FB1J RN Improving the prediction of the brain disposition for orally administered drugs using BDDCS. Adv Drug Deliv Rev. 2012 Jan;64(1):95-109. DM0FB1J RU https://doi.org/10.1016/j.addr.2011.12.008 DM0FB1J DI DM0FB1J DM0FB1J DN Sertraline DM0FB1J MI TT3ROYC DM0FB1J MN Serotonin transporter (SERT) DM0FB1J MT DTT DM0FB1J MA Inhibitor DM0FB1J RN Psychopharmacological treatment of dermatological patients--when simply talking does not help. J Dtsch Dermatol Ges. 2007 Dec;5(12):1101-6. DM0FB1J RU https://pubmed.ncbi.nlm.nih.gov/17877739 DMPVRN9 DI DMPVRN9 DMPVRN9 DN Setmelanotide DMPVRN9 MI TTD0CIQ DMPVRN9 MN Melanocortin receptor 4 (MC4R) DMPVRN9 MT DTT DMPVRN9 MA Agonist DMPVRN9 RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health Human Services. 2020 DMPVRN9 RU https://www.accessdata.fda.gov/drugsatfda_docs/label/2020/213793s000lbl.pdf DMC9O43 DI DMC9O43 DMC9O43 DN Sevoflurane DMC9O43 MI DEJVYAZ DMC9O43 MN Cytochrome P450 2A6 (CYP2A6) DMC9O43 MT DME DMC9O43 MA Metabolism DMC9O43 RN Human kidney methoxyflurane and sevoflurane metabolism. Intrarenal fluoride production as a possible mechanism of methoxyflurane nephrotoxicity. Anesthesiology. 1995 Mar;82(3):689-99. DMC9O43 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=7879937 DMC9O43 DI DMC9O43 DMC9O43 DN Sevoflurane DMC9O43 MI DEPKLMQ DMC9O43 MN Cytochrome P450 2B6 (CYP2B6) DMC9O43 MT DME DMC9O43 MA Metabolism DMC9O43 RN Summary of information on human CYP enzymes: human P450 metabolism data. Drug Metab Rev. 2002 Feb-May;34(1-2):83-448. DMC9O43 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=11996015 DMC9O43 DI DMC9O43 DMC9O43 DN Sevoflurane DMC9O43 MI DEVDYN7 DMC9O43 MN Cytochrome P450 2E1 (CYP2E1) DMC9O43 MT DME DMC9O43 MA Metabolism DMC9O43 RN Inhibition of cytochrome P450 2E1 by propofol in human and porcine liver microsomes. Biochem Pharmacol. 2002 Oct 1;64(7):1151-6. DMC9O43 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=12234619 DMC9O43 DI DMC9O43 DMC9O43 DN Sevoflurane DMC9O43 MI DE4LYSA DMC9O43 MN Cytochrome P450 3A4 (CYP3A4) DMC9O43 MT DME DMC9O43 MA Metabolism DMC9O43 RN Identification of cytochrome P450 2E1 as the predominant enzyme catalyzing human liver microsomal defluorination of sevoflurane, isoflurane, and methoxyflurane. Anesthesiology. 1993 Oct;79(4):795-807. DMC9O43 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=8214760 DMC9O43 DI DMC9O43 DMC9O43 DN Sevoflurane DMC9O43 MI TTAN6JD DMC9O43 MN Glutamate receptor AMPA (GRIA) DMC9O43 MT DTT DMC9O43 MA Antagonist DMC9O43 RN Effects of sevoflurane on carrageenan- and fentanyl-induced pain hypersensitivity in Sprague-Dawley rats. Can J Anaesth. 2009 Feb;56(2):126-35. DMC9O43 RU https://pubmed.ncbi.nlm.nih.gov/19247760 DMFJTDI DI DMFJTDI DMFJTDI DN Sibutramine DMFJTDI MI DE4LYSA DMFJTDI MN Cytochrome P450 3A4 (CYP3A4) DMFJTDI MT DME DMFJTDI MA Metabolism DMFJTDI RN Sibutramine: a serotonin-norepinephrine reuptake-inhibitor for the treatment of obesity. Ann Pharmacother. 1999 Sep;33(9):968-78. DMFJTDI RU https://www.ncbi.nlm.nih.gov/pubmed/?term=10492502 DMFJTDI DI DMFJTDI DMFJTDI DN Sibutramine DMFJTDI MI TTAWNKZ DMFJTDI MN Norepinephrine transporter (NET) DMFJTDI MT DTT DMFJTDI MA Modulator DMFJTDI RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. DMFJTDI RU https://www.fda.gov/ DMFJTDI DI DMFJTDI DMFJTDI DN Sibutramine DMFJTDI MI TT3ROYC DMFJTDI MN Serotonin transporter (SERT) DMFJTDI MT DTT DMFJTDI MA Modulator DMFJTDI RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. DMFJTDI RU https://www.fda.gov/ DM1BS03 DI DM1BS03 DM1BS03 DN Sifalimumab DM1BS03 MI TTMQB37 DM1BS03 MN Interferon alpha/beta receptor 2 (IFNAR2) DM1BS03 MT DTT DM1BS03 RN Clinical pipeline report, company report or official report of AstraZeneca (2009). DM1BS03 RU http://www.astrazeneca.com/_mshost3690701/content/resources/media/investors/AZN-Q2-2009/AZN-Q2-2009-Pipeline.pdf DMSWJ5X DI DMSWJ5X DMSWJ5X DN Sildenafil citrate DMSWJ5X MI DE5IED8 DMSWJ5X MN Cytochrome P450 2C9 (CYP2C9) DMSWJ5X MT DME DMSWJ5X MA Metabolism DMSWJ5X RN Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. DMSWJ5X RU https://www.ncbi.nlm.nih.gov/pubmed/?term=19515014 DMSWJ5X DI DMSWJ5X DMSWJ5X DN Sildenafil citrate DMSWJ5X MI DECB0K3 DMSWJ5X MN Cytochrome P450 2D6 (CYP2D6) DMSWJ5X MT DME DMSWJ5X MA Metabolism DMSWJ5X RN Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. DMSWJ5X RU https://www.ncbi.nlm.nih.gov/pubmed/?term=19515014 DMSWJ5X DI DMSWJ5X DMSWJ5X DN Sildenafil citrate DMSWJ5X MI DEVDYN7 DMSWJ5X MN Cytochrome P450 2E1 (CYP2E1) DMSWJ5X MT DME DMSWJ5X MA Metabolism DMSWJ5X RN Erectile dysfunction drugs changed the protein expressions and activities of drug-metabolising enzymes in the liver of male rats. Oxid Med Cell Longev. 2016;2016:4970906. DMSWJ5X RU https://www.ncbi.nlm.nih.gov/pubmed/?term=27800121 DMSWJ5X DI DMSWJ5X DMSWJ5X DN Sildenafil citrate DMSWJ5X MI DE4LYSA DMSWJ5X MN Cytochrome P450 3A4 (CYP3A4) DMSWJ5X MT DME DMSWJ5X MA Metabolism DMSWJ5X RN Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. DMSWJ5X RU https://www.ncbi.nlm.nih.gov/pubmed/?term=19515014 DMSWJ5X DI DMSWJ5X DMSWJ5X DN Sildenafil citrate DMSWJ5X MI DEIBDNY DMSWJ5X MN Cytochrome P450 3A5 (CYP3A5) DMSWJ5X MT DME DMSWJ5X MA Metabolism DMSWJ5X RN The contributions of cytochromes P450 3A4 and 3A5 to the metabolism of the phosphodiesterase type 5 inhibitors sildenafil, udenafil, and vardenafil. Drug Metab Dispos. 2008 Jun;36(6):986-90. DMSWJ5X RU https://www.ncbi.nlm.nih.gov/pubmed/?term=18308836 DMSWJ5X DI DMSWJ5X DMSWJ5X DN Sildenafil citrate DMSWJ5X MI DERD86B DMSWJ5X MN Cytochrome P450 3A7 (CYP3A7) DMSWJ5X MT DME DMSWJ5X MA Metabolism DMSWJ5X RN Drug Interactions Flockhart Table DMSWJ5X RU https://drug-interactions.medicine.iu.edu/Main-Table.aspx DMSWJ5X DI DMSWJ5X DMSWJ5X DN Sildenafil citrate DMSWJ5X MI DEGTFWK DMSWJ5X MN Mephenytoin 4-hydroxylase (CYP2C19) DMSWJ5X MT DME DMSWJ5X MA Metabolism DMSWJ5X RN Identification of the cytochrome P450 enzymes involved in the N-demethylation of sildenafil. Br J Clin Pharmacol. 2001 Mar;51(3):239-48. DMSWJ5X RU https://www.ncbi.nlm.nih.gov/pubmed/?term=11298070 DMJSBT6 DI DMJSBT6 DMJSBT6 DN Silodosin DMJSBT6 MI TTNGILX DMJSBT6 MN Adrenergic receptor alpha-1A (ADRA1A) DMJSBT6 MT DTT DMJSBT6 MA Inhibitor DMJSBT6 RN Pharmacophore identification of alpha(1A)-adrenoceptor antagonists. Bioorg Med Chem Lett. 2005 Feb 1;15(3):657-64. DMJSBT6 RU https://pubmed.ncbi.nlm.nih.gov/15664832 DMJSBT6 DI DMJSBT6 DMJSBT6 DN Silodosin DMJSBT6 MI DEE5M8O DMJSBT6 MN Alcohol dehydrogenase class-I alpha (ADH1A) DMJSBT6 MT DME DMJSBT6 MA Metabolism DMJSBT6 RN Pharmacokinetics and disposition of silodosin (KMD-3213). Yakugaku Zasshi. 2006 Mar;126 Spec no.:237-45. DMJSBT6 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=16518089 DMJSBT6 DI DMJSBT6 DMJSBT6 DN Silodosin DMJSBT6 MI DEWYTJB DMJSBT6 MN Aldehyde dehydrogenase 2 (ALDH2) DMJSBT6 MT DME DMJSBT6 MA Metabolism DMJSBT6 RN Pharmacokinetics and disposition of silodosin (KMD-3213). Yakugaku Zasshi. 2006 Mar;126 Spec no.:237-45. DMJSBT6 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=16518089 DMJSBT6 DI DMJSBT6 DMJSBT6 DN Silodosin DMJSBT6 MI DE4LYSA DMJSBT6 MN Cytochrome P450 3A4 (CYP3A4) DMJSBT6 MT DME DMJSBT6 MA Metabolism DMJSBT6 RN Silodosin for benign prostatic hyperplasia. Ann Pharmacother. 2010 Feb;44(2):302-10. DMJSBT6 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=20071497 DMJSBT6 DI DMJSBT6 DMJSBT6 DN Silodosin DMJSBT6 MI DTZRMK5 DMJSBT6 MN Multidrug resistance protein 3 (ABCB4) DMJSBT6 MT DTP DMJSBT6 MA Substrate DMJSBT6 RN Pharmacokinetics and disposition of silodosin (KMD-3213)]. Yakugaku Zasshi. 2006 Mar;126 Spec no.:237-45. DMJSBT6 RU http://www.ncbi.nlm.nih.gov/pubmed/16518089 DMJSBT6 DI DMJSBT6 DMJSBT6 DN Silodosin DMJSBT6 MI DTUGYRD DMJSBT6 MN P-glycoprotein 1 (ABCB1) DMJSBT6 MT DTP DMJSBT6 MA Substrate DMJSBT6 RN The influence of UGT2B7, UGT1A8, MDR1, ALDH, ADH, CYP3A4 and CYP3A5 genetic polymorphisms on the pharmacokinetics of silodosin in healthy Chinese volunteers. Drug Metab Pharmacokinet. 2013;28(3):239-43. DMJSBT6 RU http://www.ncbi.nlm.nih.gov/pubmed/23257391 DMJSBT6 DI DMJSBT6 DMJSBT6 DN Silodosin DMJSBT6 MI DEB3CV1 DMJSBT6 MN UDP-glucuronosyltransferase 2B7 (UGT2B7) DMJSBT6 MT DME DMJSBT6 MA Metabolism DMJSBT6 RN Pharmacokinetics and disposition of silodosin (KMD-3213). Yakugaku Zasshi. 2006 Mar;126 Spec no.:237-45. DMJSBT6 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=16518089 DMGEATB DI DMGEATB DMGEATB DN Siltuximab DMGEATB MI TTT1V78 DMGEATB MN Interleukin-6 (IL6) DMGEATB MT DTT DMGEATB RN 2014 FDA drug approvals. Nat Rev Drug Discov. 2015 Feb;14(2):77-81. DMGEATB RU https://pubmed.ncbi.nlm.nih.gov/25633781 DMVTHWQ DI DMVTHWQ DMVTHWQ DN Silver sulfadiazine DMVTHWQ MI TT4ILYC DMVTHWQ MN Bacterial Dihydropteroate synthetase (Bact folP) DMVTHWQ MT DTT DMVTHWQ MA Binder DMVTHWQ RN Comparative evaluation of transdermal formulations of norfloxacin with silver sulfadiazine cream, USP, for burn wound healing property. J Burns Wounds. 2006 Jun 7;5:e4. DMVTHWQ RU https://pubmed.ncbi.nlm.nih.gov/16921417 DMLUA9D DI DMLUA9D DMLUA9D DN Simeprevir DMLUA9D MI DE4LYSA DMLUA9D MN Cytochrome P450 3A4 (CYP3A4) DMLUA9D MT DME DMLUA9D MA Metabolism DMLUA9D RN Hepatitis C virus direct-acting antiviral drug interactions and use in renal and hepatic impairment. Top Antivir Med. 2015 May-Jun;23(2):92-6. DMLUA9D RU https://www.ncbi.nlm.nih.gov/pubmed/?term=26200709 DMLUA9D DI DMLUA9D DMLUA9D DN Simeprevir DMLUA9D MI TTHC7JD DMLUA9D MN Hepatitis C virus Serine protease NS3/4A (HCV NS3/4A) DMLUA9D MT DTT DMLUA9D MA Modulator DMLUA9D RN Radium 223 dichloride for prostate cancer treatment. Drug Des Devel Ther. 2017 Sep 6;11:2643-2651. DMLUA9D RU https://pubmed.ncbi.nlm.nih.gov/28919714 DMLUA9D DI DMLUA9D DMLUA9D DN Simeprevir DMLUA9D MI DT3D8F0 DMLUA9D MN Organic anion transporting polypeptide 1B1 (SLCO1B1) DMLUA9D MT DTP DMLUA9D MA Substrate DMLUA9D RN Drug-Drug Interactions with the NS3/4A Protease Inhibitor Simeprevir. Clin Pharmacokinet. 2016 Feb;55(2):197-208. DMLUA9D RU http://www.ncbi.nlm.nih.gov/pubmed/26353895 DMLUA9D DI DMLUA9D DMLUA9D DN Simeprevir DMLUA9D MI DTUGYRD DMLUA9D MN P-glycoprotein 1 (ABCB1) DMLUA9D MT DTP DMLUA9D MA Substrate DMLUA9D RN KEGG: new perspectives on genomes, pathways, diseases and drugs. Nucleic Acids Res. 2017 Jan 4;45(D1):D353-D361. (dg:DG01665) DMLUA9D RU https://www.kegg.jp/dbget-bin/www_bget?dg:DG01665 DM30SGU DI DM30SGU DM30SGU DN Simvastatin DM30SGU MI DTI7UX6 DM30SGU MN Breast cancer resistance protein (ABCG2) DM30SGU MT DTP DM30SGU MA Substrate DM30SGU RN Human intestinal transporter database: QSAR modeling and virtual profiling of drug uptake, efflux and interactions. Pharm Res. 2013 Apr;30(4):996-1007. DM30SGU RU https://doi.org/10.1007/s11095-012-0935-x DM30SGU DI DM30SGU DM30SGU DN Simvastatin DM30SGU MI DES5XRU DM30SGU MN Cytochrome P450 2C8 (CYP2C8) DM30SGU MT DME DM30SGU MA Metabolism DM30SGU RN Drug interactions with lipid-lowering drugs: mechanisms and clinical relevance. Clin Pharmacol Ther. 2006 Dec;80(6):565-81. DM30SGU RU https://www.ncbi.nlm.nih.gov/pubmed/?term=17178259 DM30SGU DI DM30SGU DM30SGU DN Simvastatin DM30SGU MI DECB0K3 DM30SGU MN Cytochrome P450 2D6 (CYP2D6) DM30SGU MT DME DM30SGU MA Metabolism DM30SGU RN Genetic polymorphisms in cytochrome P450 enzymes: effect on efficacy and tolerability of HMG-CoA reductase inhibitors. Am J Cardiovasc Drugs. 2004;4(4):247-55. DM30SGU RU https://www.ncbi.nlm.nih.gov/pubmed/?term=15285699 DM30SGU DI DM30SGU DM30SGU DN Simvastatin DM30SGU MI DE4LYSA DM30SGU MN Cytochrome P450 3A4 (CYP3A4) DM30SGU MT DME DM30SGU MA Metabolism DM30SGU RN A comparison of the effects of 3-hydroxy-3-methylglutaryl-coenzyme a (HMG-CoA) reductase inhibitors on the CYP3A4-dependent oxidation of mexazolam in vitro. Drug Metab Dispos. 2001 Mar;29(3):282-8. DM30SGU RU https://www.ncbi.nlm.nih.gov/pubmed/?term=11181496 DM30SGU DI DM30SGU DM30SGU DN Simvastatin DM30SGU MI DEIBDNY DM30SGU MN Cytochrome P450 3A5 (CYP3A5) DM30SGU MT DME DM30SGU MA Metabolism DM30SGU RN In vitro metabolism of simvastatin in humans [SBT]identification of metabolizing enzymes and effect of the drug on hepatic P450s. Drug Metab Dispos. 1997 Oct;25(10):1191-9. DM30SGU RU https://www.ncbi.nlm.nih.gov/pubmed/?term=9321523 DM30SGU DI DM30SGU DM30SGU DN Simvastatin DM30SGU MI TTPADOQ DM30SGU MN HMG-CoA reductase (HMGCR) DM30SGU MT DTT DM30SGU MA Inhibitor DM30SGU RN Equally potent inhibitors of cholesterol synthesis in human hepatocytes have distinguishable effects on different cytochrome P450 enzymes. Biopharm Drug Dispos. 2000 Dec;21(9):353-64. DM30SGU RU https://pubmed.ncbi.nlm.nih.gov/11523064 DM30SGU DI DM30SGU DM30SGU DN Simvastatin DM30SGU MI DEGTFWK DM30SGU MN Mephenytoin 4-hydroxylase (CYP2C19) DM30SGU MT DME DM30SGU MA Metabolism DM30SGU RN Pharmacogenomics of statins: understanding susceptibility to adverse effects. Pharmgenomics Pers Med. 2016 Oct 3;9:97-106. DM30SGU RU https://www.ncbi.nlm.nih.gov/pubmed/?term=27757045 DM30SGU DI DM30SGU DM30SGU DN Simvastatin DM30SGU MI DT3D8F0 DM30SGU MN Organic anion transporting polypeptide 1B1 (SLCO1B1) DM30SGU MT DTP DM30SGU MA Substrate DM30SGU RN Impact of OATP transporters on pharmacokinetics. Br J Pharmacol. 2009 Oct;158(3):693-705. DM30SGU RU http://www.ncbi.nlm.nih.gov/pubmed/19785645 DM30SGU DI DM30SGU DM30SGU DN Simvastatin DM30SGU MI DTUGYRD DM30SGU MN P-glycoprotein 1 (ABCB1) DM30SGU MT DTP DM30SGU MA Substrate DM30SGU RN Mammalian drug efflux transporters of the ATP binding cassette (ABC) family in multidrug resistance: A review of the past decade. Cancer Lett. 2016 Jan 1;370(1):153-64. DM30SGU RU http://www.ncbi.nlm.nih.gov/pubmed/26499806 DM30SGU DI DM30SGU DM30SGU DN Simvastatin DM30SGU MI DEYGVN4 DM30SGU MN UDP-glucuronosyltransferase 1A1 (UGT1A1) DM30SGU MT DME DM30SGU MA Metabolism DM30SGU RN Pharmacogenomics of statins: understanding susceptibility to adverse effects. Pharmgenomics Pers Med. 2016 Oct 3;9:97-106. DM30SGU RU https://www.ncbi.nlm.nih.gov/pubmed/?term=27757045 DM30SGU DI DM30SGU DM30SGU DN Simvastatin DM30SGU MI DEF2WXN DM30SGU MN UDP-glucuronosyltransferase 1A3 (UGT1A3) DM30SGU MT DME DM30SGU MA Metabolism DM30SGU RN Pharmacogenomics of statins: understanding susceptibility to adverse effects. Pharmgenomics Pers Med. 2016 Oct 3;9:97-106. DM30SGU RU https://www.ncbi.nlm.nih.gov/pubmed/?term=27757045 DM30SGU DI DM30SGU DM30SGU DN Simvastatin DM30SGU MI DEB3CV1 DM30SGU MN UDP-glucuronosyltransferase 2B7 (UGT2B7) DM30SGU MT DME DM30SGU MA Metabolism DM30SGU RN Pharmacogenomics of statins: understanding susceptibility to adverse effects. Pharmgenomics Pers Med. 2016 Oct 3;9:97-106. DM30SGU RU https://www.ncbi.nlm.nih.gov/pubmed/?term=27757045 DMGWR0C DI DMGWR0C DMGWR0C DN Sintilimab DMGWR0C MI TTNBFWK DMGWR0C MN Programmed cell death protein 1 (PD-1) DMGWR0C MT DTT DMGWR0C MA Inhibitor DMGWR0C RN Sintilimab: First Global Approval. Drugs. 2019 Feb;79(3):341-346. DMGWR0C RU https://pubmed.ncbi.nlm.nih.gov/30742278 DM2R86O DI DM2R86O DM2R86O DN Siponimod DM2R86O MI DE5IED8 DM2R86O MN Cytochrome P450 2C9 (CYP2C9) DM2R86O MT DME DM2R86O MA Metabolism DM2R86O RN Metabolism and disposition of siponimod, a novel selective S1P1/S1P5 agonist, in healthy volunteers and in vitro identification of human cytochrome P450 enzymes involved in its oxidative metabolism. Drug Metab Dispos. 2018 Jul;46(7):1001-1013. DM2R86O RU https://www.ncbi.nlm.nih.gov/pubmed/?term=29735753 DMVCMUJ DI DMVCMUJ DMVCMUJ DN Siponimod DMVCMUJ MI DE5IED8 DMVCMUJ MN Cytochrome P450 2C9 (CYP2C9) DMVCMUJ MT DME DMVCMUJ MA Metabolism DMVCMUJ RN Metabolism and disposition of siponimod, a novel selective S1P1/S1P5 agonist, in healthy volunteers and in vitro identification of human cytochrome P450 enzymes involved in its oxidative metabolism. Drug Metab Dispos. 2018 Jul;46(7):1001-1013. DMVCMUJ RU https://www.ncbi.nlm.nih.gov/pubmed/?term=29735753 DM2R86O DI DM2R86O DM2R86O DN Siponimod DM2R86O MI DE4LYSA DM2R86O MN Cytochrome P450 3A4 (CYP3A4) DM2R86O MT DME DM2R86O MA Metabolism DM2R86O RN Metabolism and disposition of siponimod, a novel selective S1P1/S1P5 agonist, in healthy volunteers and in vitro identification of human cytochrome P450 enzymes involved in its oxidative metabolism. Drug Metab Dispos. 2018 Jul;46(7):1001-1013. DM2R86O RU https://www.ncbi.nlm.nih.gov/pubmed/?term=29735753 DMVCMUJ DI DMVCMUJ DMVCMUJ DN Siponimod DMVCMUJ MI DE4LYSA DMVCMUJ MN Cytochrome P450 3A4 (CYP3A4) DMVCMUJ MT DME DMVCMUJ MA Metabolism DMVCMUJ RN Metabolism and disposition of siponimod, a novel selective S1P1/S1P5 agonist, in healthy volunteers and in vitro identification of human cytochrome P450 enzymes involved in its oxidative metabolism. Drug Metab Dispos. 2018 Jul;46(7):1001-1013. DMVCMUJ RU https://www.ncbi.nlm.nih.gov/pubmed/?term=29735753 DM2R86O DI DM2R86O DM2R86O DN Siponimod DM2R86O MI TT7BQRM DM2R86O MN Sphingosine-1 phosphate receptor (S1PR) DM2R86O MT DTT DM2R86O MA Modulator DM2R86O RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health Human Services. 2019 DM2R86O RU https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/209884s000lbl.pdf DM2R86O DI DM2R86O DM2R86O DN Siponimod DM2R86O MI TT9JZCK DM2R86O MN Sphingosine-1-phosphate receptor 1 (S1PR1) DM2R86O MT DTT DM2R86O MA Modulator DM2R86O RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health Human Services. 2019 DM2R86O RU https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/209884s000lbl.pdf DMGW1ID DI DMGW1ID DMGW1ID DN Sirolimus DMGW1ID MI DE4LYSA DMGW1ID MN Cytochrome P450 3A4 (CYP3A4) DMGW1ID MT DME DMGW1ID MA Metabolism DMGW1ID RN Summary of information on human CYP enzymes: human P450 metabolism data. Drug Metab Rev. 2002 Feb-May;34(1-2):83-448. DMGW1ID RU https://www.ncbi.nlm.nih.gov/pubmed/?term=11996015 DMGW1ID DI DMGW1ID DMGW1ID DN Sirolimus DMGW1ID MI DEIBDNY DMGW1ID MN Cytochrome P450 3A5 (CYP3A5) DMGW1ID MT DME DMGW1ID MA Metabolism DMGW1ID RN Drug Interactions Flockhart Table DMGW1ID RU https://drug-interactions.medicine.iu.edu/Main-Table.aspx DMGW1ID DI DMGW1ID DMGW1ID DN Sirolimus DMGW1ID MI DERD86B DMGW1ID MN Cytochrome P450 3A7 (CYP3A7) DMGW1ID MT DME DMGW1ID MA Metabolism DMGW1ID RN Drug Interactions Flockhart Table DMGW1ID RU https://drug-interactions.medicine.iu.edu/Main-Table.aspx DMGW1ID DI DMGW1ID DMGW1ID DN Sirolimus DMGW1ID MI DT3D8F0 DMGW1ID MN Organic anion transporting polypeptide 1B1 (SLCO1B1) DMGW1ID MT DTP DMGW1ID MA Substrate DMGW1ID RN Pharmacokinetic and pharmacodynamic interactions between the immunosuppressant sirolimus and the lipid-lowering drug ezetimibe in healthy volunteers. Clin Pharmacol Ther. 2010 Jun;87(6):663-7. DMGW1ID RU http://www.ncbi.nlm.nih.gov/pubmed/20220747 DMGW1ID DI DMGW1ID DMGW1ID DN Sirolimus DMGW1ID MI DTUGYRD DMGW1ID MN P-glycoprotein 1 (ABCB1) DMGW1ID MT DTP DMGW1ID MA Substrate DMGW1ID RN Pharmacogenetics of tacrolimus and sirolimus in renal transplant patients: from retrospective analyses to prospective studies. Transplant Proc. 2007 Sep;39(7):2142-4. DMGW1ID RU http://www.ncbi.nlm.nih.gov/pubmed/17889118 DMGW1ID DI DMGW1ID DMGW1ID DN Sirolimus DMGW1ID MI TTGQUFK DMGW1ID MN PI3K/AKT/mTOR pathway (PAm pathway) DMGW1ID MT DTT DMGW1ID MA Inhibitor DMGW1ID RN The genomic landscape of nasopharyngeal carcinoma.Nat Genet. 2014 Aug;46(8):866-71. DMGW1ID RU https://pubmed.ncbi.nlm.nih.gov/24952746 DMGW1ID DI DMGW1ID DMGW1ID DN Sirolimus DMGW1ID MI TTCJG29 DMGW1ID MN Serine/threonine-protein kinase mTOR (mTOR) DMGW1ID MT DTT DMGW1ID MA Inhibitor DMGW1ID RN Knockouts model the 100 best-selling drugs--will they model the next 100 Nat Rev Drug Discov. 2003 Jan;2(1):38-51. DMGW1ID RU https://pubmed.ncbi.nlm.nih.gov/12509758 DM92P0F DI DM92P0F DM92P0F DN Sisomicin DM92P0F MI DE5WGIM DM92P0F MN Aminoglycoside phosphotransferase (aph-Ib) DM92P0F MT DME DM92P0F MA Metabolism DM92P0F RN Novel aminoglycoside 2''-phosphotransferase identified in a gram-negative pathogen. Antimicrob Agents Chemother. 2013 Jan;57(1):452-7. DM92P0F RU https://pubmed.ncbi.nlm.nih.gov/23129050 DMGDKXN DI DMGDKXN DMGDKXN DN Sitagliptin DMGDKXN MI DES5XRU DMGDKXN MN Cytochrome P450 2C8 (CYP2C8) DMGDKXN MT DME DMGDKXN MA Metabolism DMGDKXN RN Pharmacokinetics of dipeptidylpeptidase-4 inhibitors. Diabetes Obes Metab. 2010 Aug;12(8):648-58. DMGDKXN RU https://www.ncbi.nlm.nih.gov/pubmed/?term=20590741 DMGDKXN DI DMGDKXN DMGDKXN DN Sitagliptin DMGDKXN MI DE4LYSA DMGDKXN MN Cytochrome P450 3A4 (CYP3A4) DMGDKXN MT DME DMGDKXN MA Metabolism DMGDKXN RN Pharmacokinetics of dipeptidylpeptidase-4 inhibitors. Diabetes Obes Metab. 2010 Aug;12(8):648-58. DMGDKXN RU https://www.ncbi.nlm.nih.gov/pubmed/?term=20590741 DMGDKXN DI DMGDKXN DMGDKXN DN Sitagliptin DMGDKXN MI TTDIGC1 DMGDKXN MN Dipeptidyl peptidase 4 (DPP-4) DMGDKXN MT DTT DMGDKXN MA Inhibitor DMGDKXN RN Novel therapeutics for type 2 diabetes: incretin hormone mimetics (glucagon-like peptide-1 receptor agonists) and dipeptidyl peptidase-4 inhibitors. Pharmacol Ther. 2009 Oct;124(1):113-38. DMGDKXN RU https://pubmed.ncbi.nlm.nih.gov/19545590 DMGDKXN DI DMGDKXN DMGDKXN DN Sitagliptin DMGDKXN MI DTVP67E DMGDKXN MN Organic anion transporter 3 (SLC22A8) DMGDKXN MT DTP DMGDKXN MA Substrate DMGDKXN RN Transport of the dipeptidyl peptidase-4 inhibitor sitagliptin by human organic anion transporter 3, organic anion transporting polypeptide 4C1, and multidrug resistance P-glycoprotein. J Pharmacol Exp Ther. 2007 May;321(2):673-83. DMGDKXN RU http://www.ncbi.nlm.nih.gov/pubmed/17314201 DMGDKXN DI DMGDKXN DMGDKXN DN Sitagliptin DMGDKXN MI DTT79CX DMGDKXN MN Organic cation transporter 1 (SLC22A1) DMGDKXN MT DTP DMGDKXN MA Substrate DMGDKXN RN 265 effect of dietary cholesterol on gallbladder bile lithogenicity and gene expression in the enterohepatic axis of non-obese gallstone and control women. Journal of Hepatology, 2009, 50(09):S105-S106. DMGDKXN RU https://doi.org/10.1016/S0168-8278(09)60267-1 DMGDKXN DI DMGDKXN DMGDKXN DN Sitagliptin DMGDKXN MI DTUGYRD DMGDKXN MN P-glycoprotein 1 (ABCB1) DMGDKXN MT DTP DMGDKXN MA Substrate DMGDKXN RN Tarascon Pocket Pharmacopoeia 2018 Classic Shirt-Pocket Edition. DMGDKXN RU https://books.google.com/books?id=0gBRDwAAQBAJ&pg=PP37&lpg=PP37&dq=Methylergonovine+transporter+uptake+efflex&source=bl&ots=cUTe_ppsmZ&sig=ACfU3U3E_YqrDg0CNEuj8K-7lci47HAnrg&hl=zh-CN&sa=X&ved=2ahUKEwjnj-Dk7d7iAhUsK6YKHd5DBDkQ6AEwEnoECAgQAQ#v=onepage&q&f=false DMQ8E9R DI DMQ8E9R DMQ8E9R DN SKI-758 DMQ8E9R MI TTGKNB4 DMQ8E9R MN Epidermal growth factor receptor (EGFR) DMQ8E9R MT DTT DMQ8E9R MA Inhibitor DMQ8E9R RN Synthesis and Src kinase inhibitory activity of a series of 4-[(2,4-dichloro-5-methoxyphenyl)amino]-7-furyl-3-quinolinecarbonitriles. J Med Chem. 2006 Dec 28;49(26):7868-76. DMQ8E9R RU https://pubmed.ncbi.nlm.nih.gov/17181170 DMQ8E9R DI DMQ8E9R DMQ8E9R DN SKI-758 DMQ8E9R MI TT6PKBN DMQ8E9R MN Proto-oncogene c-Src (SRC) DMQ8E9R MT DTT DMQ8E9R MA Inhibitor DMQ8E9R RN Synthesis and Src kinase inhibitory activity of a series of 4-[(2,4-dichloro-5-methoxyphenyl)amino]-7-furyl-3-quinolinecarbonitriles. J Med Chem. 2006 Dec 28;49(26):7868-76. DMQ8E9R RU https://pubmed.ncbi.nlm.nih.gov/17181170 DMQ8E9R DI DMQ8E9R DMQ8E9R DN SKI-758 DMQ8E9R MI TT3PJMV DMQ8E9R MN Tyrosine-protein kinase ABL1 (ABL) DMQ8E9R MT DTT DMQ8E9R MA Inhibitor DMQ8E9R RN Synthesis and Src kinase inhibitory activity of a series of 4-[(2,4-dichloro-5-methoxyphenyl)amino]-7-furyl-3-quinolinecarbonitriles. J Med Chem. 2006 Dec 28;49(26):7868-76. DMQ8E9R RU https://pubmed.ncbi.nlm.nih.gov/17181170 DMDIZCS DI DMDIZCS DMDIZCS DN S-licarbazepine DMDIZCS MI DTUGYRD DMDIZCS MN P-glycoprotein 1 (ABCB1) DMDIZCS MT DTP DMDIZCS MA Substrate DMDIZCS RN In vitro transport profile of carbamazepine, oxcarbazepine, eslicarbazepine acetate, and their active metabolites by human P-glycoprotein. Epilepsia. 2011 Oct;52(10):1894-904. DMDIZCS RU https://doi.org/10.1111/j.1528-1167.2011.03140.x DMFX9O6 DI DMFX9O6 DMFX9O6 DN SM-101 DMFX9O6 MI TTXT21W DMFX9O6 MN Immunoglobulin gamma Fc receptor IIA (FCGR2A) DMFX9O6 MT DTT DMFX9O6 MA Antagonist DMFX9O6 RN Emerging drugs for idiopathic thrombocytopenic purpura in adults. Expert Opin Emerg Drugs. 2008 Jun;13(2):237-54. DMFX9O6 RU https://pubmed.ncbi.nlm.nih.gov/18537519 DMFX9O6 DI DMFX9O6 DMFX9O6 DN SM-101 DMFX9O6 MI TTYT93M DMFX9O6 MN MAP kinase p38 (MAPK12) DMFX9O6 MT DTT DMFX9O6 MA Inhibitor DMFX9O6 RN Agents in development for the treatment of diabetic nephropathy. Expert Opin Emerg Drugs. 2008 Sep;13(3):447-63. DMFX9O6 RU https://pubmed.ncbi.nlm.nih.gov/18764722 DM1I93C DI DM1I93C DM1I93C DN SMT-D002 DM1I93C MI TTZ9SOR DM1I93C MN Muscarinic acetylcholine receptor M1 (CHRM1) DM1I93C MT DTT DM1I93C MA Agonist DM1I93C RN Demonstration of bladder selective muscarinic receptor binding by intravesical oxybutynin to treat overactive bladder. J Urol. 2004 Nov;172(5 Pt 1):2059-64. DM1I93C RU https://pubmed.ncbi.nlm.nih.gov/15540789 DM1I93C DI DM1I93C DM1I93C DN SMT-D002 DM1I93C MI TTYEG6Q DM1I93C MN Muscarinic acetylcholine receptor M2 (CHRM2) DM1I93C MT DTT DM1I93C MA Agonist DM1I93C RN Demonstration of bladder selective muscarinic receptor binding by intravesical oxybutynin to treat overactive bladder. J Urol. 2004 Nov;172(5 Pt 1):2059-64. DM1I93C RU https://pubmed.ncbi.nlm.nih.gov/15540789 DM1I93C DI DM1I93C DM1I93C DN SMT-D002 DM1I93C MI TTQ13Z5 DM1I93C MN Muscarinic acetylcholine receptor M3 (CHRM3) DM1I93C MT DTT DM1I93C MA Agonist DM1I93C RN Demonstration of bladder selective muscarinic receptor binding by intravesical oxybutynin to treat overactive bladder. J Urol. 2004 Nov;172(5 Pt 1):2059-64. DM1I93C RU https://pubmed.ncbi.nlm.nih.gov/15540789 DMH21E0 DI DMH21E0 DMH21E0 DN Sodium acetate anhydrous DMH21E0 MI DEE76VW DMH21E0 MN Acetyl-CoA synthetase (ACSS2) DMH21E0 MT DME DMH21E0 MA Metabolism DMH21E0 RN Sodium acetate induces a metabolic alkalosis but not the increase in fatty acid oxidation observed following bicarbonate ingestion in humans. J Nutr. 2007 Jul;137(7):1750-6. DMH21E0 RU http://jn.nutrition.org/content/137/7/1750.full DMMU6BJ DI DMMU6BJ DMMU6BJ DN Sodium bicarbonate DMMU6BJ MI DTSQY0W DMMU6BJ MN Anion exchange protein 4 (SLC4A9) DMMU6BJ MT DTP DMMU6BJ MA Substrate DMMU6BJ RN A novel sodium bicarbonate cotransporter-like gene in an ancient duplicated region: SLC4A9 at 5q31. Genome Biol. 2001;2(4):RESEARCH0011. DMMU6BJ RU http://www.ncbi.nlm.nih.gov/pubmed/11305939 DMMU6BJ DI DMMU6BJ DMMU6BJ DN Sodium bicarbonate DMMU6BJ MI DTWDEIL DMMU6BJ MN Electrogenic sodium bicarbonate cotransporter 1 (SLC4A4) DMMU6BJ MT DTP DMMU6BJ MA Substrate DMMU6BJ RN The sodium bicarbonate cotransporter (NBCe1) is essential for normal development of mouse dentition. J Biol Chem. 2010 Aug 6;285(32):24432-8. DMMU6BJ RU http://www.ncbi.nlm.nih.gov/pubmed/20529845 DMMU6BJ DI DMMU6BJ DMMU6BJ DN Sodium bicarbonate DMMU6BJ MI DTCL4P8 DMMU6BJ MN Electrogenic sodium bicarbonate cotransporter 4 (SLC4A5) DMMU6BJ MT DTP DMMU6BJ MA Substrate DMMU6BJ RN The sodium bicarbonate cotransporter: structure, function, and regulation. Semin Nephrol. 2006 Sep;26(5):352-60. DMMU6BJ RU http://www.ncbi.nlm.nih.gov/pubmed/17071329 DMMU6BJ DI DMMU6BJ DMMU6BJ DN Sodium bicarbonate DMMU6BJ MI DTW40Z7 DMMU6BJ MN Electroneutral sodium bicarbonate exchanger 1 (SLC4A8) DMMU6BJ MT DTP DMMU6BJ MA Substrate DMMU6BJ RN The sodium bicarbonate cotransporter: structure, function, and regulation. Semin Nephrol. 2006 Sep;26(5):352-60. DMMU6BJ RU http://www.ncbi.nlm.nih.gov/pubmed/17071329 DMMU6BJ DI DMMU6BJ DMMU6BJ DN Sodium bicarbonate DMMU6BJ MI DT03V27 DMMU6BJ MN Sodium bicarbonate cotransporter 3 (SLC4A7) DMMU6BJ MT DTP DMMU6BJ MA Substrate DMMU6BJ RN The sodium bicarbonate cotransporter: structure, function, and regulation. Semin Nephrol. 2006 Sep;26(5):352-60. DMMU6BJ RU http://www.ncbi.nlm.nih.gov/pubmed/17071329 DMMU6BJ DI DMMU6BJ DMMU6BJ DN Sodium bicarbonate DMMU6BJ MI DT7RYVF DMMU6BJ MN Sodium-driven chloride bicarbonate exchanger (SLC4A10) DMMU6BJ MT DTP DMMU6BJ MA Substrate DMMU6BJ RN Molecular mechanisms of electrogenic sodium bicarbonate cotransport: structural and equilibrium thermodynamic considerations. J Membr Biol. 2004 Jan 15;197(2):77-90. DMMU6BJ RU http://www.ncbi.nlm.nih.gov/pubmed/15014910 DMMU6BJ DI DMMU6BJ DMMU6BJ DN Sodium bicarbonate DMMU6BJ MI TTZPWGN DMMU6BJ MN Voltage-gated calcium channel alpha Cav3.2 (CACNA1H) DMMU6BJ MT DTT DMMU6BJ MA Blocker DMMU6BJ RN Acute renal failure. Clin Evid (Online). 2008 Sep 3;2008. pii: 2001. DMMU6BJ RU https://pubmed.ncbi.nlm.nih.gov/19445797 DMMU6BJ DI DMMU6BJ DMMU6BJ DN Sodium bicarbonate DMMU6BJ MI TTPLQO0 DMMU6BJ MN Voltage-gated potassium channel Kv4.3 (KCND3) DMMU6BJ MT DTT DMMU6BJ MA Blocker DMMU6BJ RN Management of cocaine-induced cardiac arrhythmias due to cardiac ion channel dysfunction. Clin Toxicol (Phila). 2009 Jan;47(1):14-23. DMMU6BJ RU https://pubmed.ncbi.nlm.nih.gov/18815938 DMM3950 DI DMM3950 DMM3950 DN Sodium chloride DMM3950 MI TTQ8AFT DMM3950 MN Adrenergic receptor Alpha-2 (ADRA2) DMM3950 MT DTT DMM3950 MA Agonist DMM3950 RN Noradrenergic alpha-2 receptor agonists reverse working memory deficits induced by the anxiogenic drug, FG7142, in rats. Pharmacol Biochem Behav. 2000 Nov;67(3):397-403. DMM3950 RU https://pubmed.ncbi.nlm.nih.gov/11164065 DMM3950 DI DMM3950 DMM3950 DN Sodium chloride DMM3950 MI DTHKL3Q DMM3950 MN Basolateral Na-K-Cl symporter (SLC12A2) DMM3950 MT DTP DMM3950 MA Substrate DMM3950 RN Expression of the sodium potassium chloride cotransporter (NKCC1) and sodium chloride cotransporter (NCC) and their effects on rat lens transparency. Mol Vis. 2010 May 4;16:800-12. DMM3950 RU http://www.ncbi.nlm.nih.gov/pubmed/20458365 DMM3950 DI DMM3950 DMM3950 DN Sodium chloride DMM3950 MI DTO1UQY DMM3950 MN Bumetanide-sensitive sodium-(potassium)-chloride cotransporter 2 (SLC12A1) DMM3950 MT DTP DMM3950 MA Substrate DMM3950 RN Upregulation of renal sodium transporters in D5 dopamine receptor-deficient mice. Hypertension. 2010 Jun;55(6):1431-7. DMM3950 RU http://www.ncbi.nlm.nih.gov/pubmed/20404220 DMM3950 DI DMM3950 DMM3950 DN Sodium chloride DMM3950 MI DT6201N DMM3950 MN Organic cation transporter 3 (SLC22A3) DMM3950 MT DTP DMM3950 MA Substrate DMM3950 RN Organic cation transporter 3 (Slc22a3) is implicated in salt-intake regulation. J Neurosci. 2004 Mar 17;24(11):2846-51. DMM3950 RU http://www.ncbi.nlm.nih.gov/pubmed/15028779 DMLJ634 DI DMLJ634 DMLJ634 DN Sodium lauryl sulfate DMLJ634 MI TTFNGC9 DMLJ634 MN Serum albumin (ALB) DMLJ634 MT DTT DMLJ634 MA Binder DMLJ634 RN Some properties of the interaction between 2,2'-diselenadibenzoic acid and serum albumins. J Pharm Biomed Anal. 2005 Sep 1;39(1-2):263-7. DMLJ634 RU https://pubmed.ncbi.nlm.nih.gov/16085141 DMGA9X0 DI DMGA9X0 DMGA9X0 DN Sodium nitroprusside DMGA9X0 MI TT23PYC DMGA9X0 MN Soluble guanylate cyclase (GCS) DMGA9X0 MT DTT DMGA9X0 MA Modulator DMGA9X0 RN Stimulators and activators of soluble guanylate cyclase: review and potential therapeutic indications.Crit Care Res Pract.2012;2012:290805. DMGA9X0 RU https://www.ncbi.nlm.nih.gov/pubmed/22482042 DMCIWZL DI DMCIWZL DMCIWZL DN Sodium oxybate DMCIWZL MI DE8RJ3F DMCIWZL MN Hydroxyacid-oxoacid transhydrogenase (ADHFE1) DMCIWZL MT DME DMCIWZL MA Metabolism DMCIWZL RN Kinetic characterization of human hydroxyacid-oxoacid transhydrogenase: relevance to D-2-hydroxyglutaric and gamma-hydroxybutyric acidurias. J Inherit Metab Dis. 2005;28(6):921-30. DMCIWZL RU https://www.ncbi.nlm.nih.gov/pubmed/?term=16435184 DMCIWZL DI DMCIWZL DMCIWZL DN Sodium oxybate DMCIWZL MI DE5KEWZ DMCIWZL MN Succinate-semialdehyde dehydrogenase (ALDH5A1) DMCIWZL MT DME DMCIWZL MA Metabolism DMCIWZL RN Redox-switch modulation of human SSADH by dynamic catalytic loop. EMBO J. 2009 Apr 8;28(7):959-68. DMCIWZL RU https://www.ncbi.nlm.nih.gov/pubmed/?term=19300440 DMXLBCQ DI DMXLBCQ DMXLBCQ DN Sodium phenylbutyrate DMXLBCQ MI TTBH0VX DMXLBCQ MN Histone deacetylase (HDAC) DMXLBCQ MT DTT DMXLBCQ MA Inhibitor DMXLBCQ RN Histone Deacetylase inhibitors: new promise in the treatment of immune and inflammatory diseases. Curr Drug Targets. 2010 Nov;11(11):1430-8. DMXLBCQ RU https://pubmed.ncbi.nlm.nih.gov/20583972 DMXLBCQ DI DMXLBCQ DMXLBCQ DN Sodium phenylbutyrate DMXLBCQ MI TTFJ8Q1 DMXLBCQ MN Protein kinase C alpha (PRKCA) DMXLBCQ MT DTT DMXLBCQ MA Modulator DMXLBCQ RN Polo-like kinase inhibitor Ro5203280 has potent antitumor activity in nasopharyngeal carcinoma.Mol Cancer Ther. 2013 Aug;12(8):1393-401. DMXLBCQ RU https://pubmed.ncbi.nlm.nih.gov/23686835 DMKY27B DI DMKY27B DMKY27B DN Sodium phosphate dibasic/sodium phosphate monobasic DMKY27B MI DTWFOPY DMKY27B MN Sodium-dependent phosphate transport protein 2B (SLC34A2) DMKY27B MT DTP DMKY27B MA Substrate DMKY27B RN Phosphate transporters and their function. Annu Rev Physiol. 2013;75:535-50. DMKY27B RU http://www.ncbi.nlm.nih.gov/pubmed/23398154 DM4QFXJ DI DM4QFXJ DM4QFXJ DN Sodium Tetradecyl Sulfate DM4QFXJ MI TTZUXYS DM4QFXJ MN Vitamin K-dependent protein C (PROC) DM4QFXJ MT DTT DM4QFXJ MA Inhibitor DM4QFXJ RN Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. DM4QFXJ RU https://pubmed.ncbi.nlm.nih.gov/17016423 DMCSLZ4 DI DMCSLZ4 DMCSLZ4 DN Sodium zirconium cyclosilicate DMCSLZ4 MI TTB0SC6 DMCSLZ4 MN Potassium (K) DMCSLZ4 MT DTT DMCSLZ4 MA Binder DMCSLZ4 RN 2018 FDA drug approvals.Nat Rev Drug Discov. 2019 Feb;18(2):85-89. DMCSLZ4 RU https://pubmed.ncbi.nlm.nih.gov/30710142 DMQI86A DI DMQI86A DMQI86A DN Sofosbuvir DMQI86A MI DTI7UX6 DMQI86A MN Breast cancer resistance protein (ABCG2) DMQI86A MT DTP DMQI86A MA Substrate DMQI86A RN KEGG: new perspectives on genomes, pathways, diseases and drugs. Nucleic Acids Res. 2017 Jan 4;45(D1):D353-D361. (dg:DG01913) DMQI86A RU https://www.kegg.jp/dbget-bin/www_bget?dg:DG01913 DMQI86A DI DMQI86A DMQI86A DN Sofosbuvir DMQI86A MI DTUGYRD DMQI86A MN P-glycoprotein 1 (ABCB1) DMQI86A MT DTP DMQI86A MA Substrate DMQI86A RN Cytochrome P450 3A Induction Predicts P-glycoprotein Induction; Part 2: Prediction of Decreased Substrate Exposure After Rifabutin or Carbamazepine. Clin Pharmacol Ther. 2018 Dec;104(6):1191-1198. DMQI86A RU http://www.ncbi.nlm.nih.gov/pubmed/29569712 DM5F47O DI DM5F47O DM5F47O DN Sofosbuvir + velpatasvir + voxilaprevir DM5F47O MI TTCJ2X8 DM5F47O MN Hepatitis C virus Non-structural 5A (HCV NS5A) DM5F47O MT DTT DM5F47O MA Inhibitor DM5F47O RN 2017 FDA drug approvals.Nat Rev Drug Discov. 2018 Feb;17(2):81-85. DM5F47O RU https://pubmed.ncbi.nlm.nih.gov/29348678 DM5F47O DI DM5F47O DM5F47O DN Sofosbuvir + velpatasvir + voxilaprevir DM5F47O MI TTMVBWH DM5F47O MN Hepatitis C virus RNA-directed RNA polymerase (HCV NS5B) DM5F47O MT DTT DM5F47O MA Inhibitor DM5F47O RN 2017 FDA drug approvals.Nat Rev Drug Discov. 2018 Feb;17(2):81-85. DM5F47O RU https://pubmed.ncbi.nlm.nih.gov/29348678 DM5F47O DI DM5F47O DM5F47O DN Sofosbuvir + velpatasvir + voxilaprevir DM5F47O MI TTHC7JD DM5F47O MN Hepatitis C virus Serine protease NS3/4A (HCV NS3/4A) DM5F47O MT DTT DM5F47O MA Inhibitor DM5F47O RN 2017 FDA drug approvals.Nat Rev Drug Discov. 2018 Feb;17(2):81-85. DM5F47O RU https://pubmed.ncbi.nlm.nih.gov/29348678 DMG592Q DI DMG592Q DMG592Q DN Solifenacin DMG592Q MI DECB0K3 DMG592Q MN Cytochrome P450 2D6 (CYP2D6) DMG592Q MT DME DMG592Q MA Metabolism DMG592Q RN Clinical pharmacokinetics and pharmacodynamics of solifenacin. Clin Pharmacokinet. 2009;48(5):281-302. DMG592Q RU https://www.ncbi.nlm.nih.gov/pubmed/?term=19566112 DMG592Q DI DMG592Q DMG592Q DN Solifenacin DMG592Q MI DE4LYSA DMG592Q MN Cytochrome P450 3A4 (CYP3A4) DMG592Q MT DME DMG592Q MA Metabolism DMG592Q RN Clinical pharmacokinetics and pharmacodynamics of solifenacin. Clin Pharmacokinet. 2009;48(5):281-302. DMG592Q RU https://www.ncbi.nlm.nih.gov/pubmed/?term=19566112 DMG592Q DI DMG592Q DMG592Q DN Solifenacin DMG592Q MI TTQ13Z5 DMG592Q MN Muscarinic acetylcholine receptor M3 (CHRM3) DMG592Q MT DTT DMG592Q MA Antagonist DMG592Q RN Comparison of muscarinic receptor selectivity of solifenacin and oxybutynin in the bladder and submandibular gland of muscarinic receptor knockout ... Eur J Pharmacol. 2009 Aug 1;615(1-3):201-6. DMG592Q RU https://pubmed.ncbi.nlm.nih.gov/19446545 DMZ9FAO DI DMZ9FAO DMZ9FAO DN Somatomedin-1 DMZ9FAO MI TTHRID2 DMZ9FAO MN Insulin-like growth factor I receptor (IGF1R) DMZ9FAO MT DTT DMZ9FAO MA Modulator DMZ9FAO RN 2005 approvals: Safety first. Nature Reviews Drug Discovery 5, 92-93 (February 2006). DMZ9FAO RU http://www.nature.com/nrd/journal/v11/n1/full/nrd3645.html DMF3GM2 DI DMF3GM2 DMF3GM2 DN Somatropin recombinant DMF3GM2 MI TTKMAZ6 DMF3GM2 MN Growth hormone receptor (GHR) DMF3GM2 MT DTT DMF3GM2 MA Binder DMF3GM2 RN Cost-utility of somatropin (rDNA origin) in the treatment of growth hormone deficiency in children. Curr Med Res Opin. 2006 Feb;22(2):351-7. DMF3GM2 RU https://pubmed.ncbi.nlm.nih.gov/16466607 DM72409 DI DM72409 DM72409 DN Sonidegib phosphate DM72409 MI DE4LYSA DM72409 MN Cytochrome P450 3A4 (CYP3A4) DM72409 MT DME DM72409 MA Metabolism DM72409 RN Sonidegib: first global approval. Drugs. 2015 Sep;75(13):1559-66. DM72409 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=26323341 DMS8IFC DI DMS8IFC DMS8IFC DN Sorafenib DMS8IFC MI DTI7UX6 DMS8IFC MN Breast cancer resistance protein (ABCG2) DMS8IFC MT DTP DMS8IFC MA Substrate DMS8IFC RN Double-transduced MDCKII cells to study human P-glycoprotein (ABCB1) and breast cancer resistance protein (ABCG2) interplay in drug transport across the blood-brain barrier. Mol Pharm. 2011 Apr 4;8(2):571-82. DMS8IFC RU https://doi.org/10.1021/mp1003898 DMS8IFC DI DMS8IFC DMS8IFC DN Sorafenib DMS8IFC MI DEJGDUW DMS8IFC MN Cytochrome P450 1A2 (CYP1A2) DMS8IFC MT DME DMS8IFC MA Metabolism DMS8IFC RN Ontogeny and sorafenib metabolism. Clin Cancer Res. 2012 Oct 15;18(20):5788-95. DMS8IFC RU https://www.ncbi.nlm.nih.gov/pubmed/?term=22927483 DMS8IFC DI DMS8IFC DMS8IFC DN Sorafenib DMS8IFC MI DES5XRU DMS8IFC MN Cytochrome P450 2C8 (CYP2C8) DMS8IFC MT DME DMS8IFC MA Metabolism DMS8IFC RN Interaction of sorafenib and cytochrome P450 isoenzymes in patients with advanced melanoma: a phase I/II pharmacokinetic interaction study. Cancer Chemother Pharmacol. 2011 Nov;68(5):1111-8. DMS8IFC RU https://www.ncbi.nlm.nih.gov/pubmed/?term=21350850 DMS8IFC DI DMS8IFC DMS8IFC DN Sorafenib DMS8IFC MI DE4LYSA DMS8IFC MN Cytochrome P450 3A4 (CYP3A4) DMS8IFC MT DME DMS8IFC MA Metabolism DMS8IFC RN Interaction of sorafenib and cytochrome P450 isoenzymes in patients with advanced melanoma: a phase I/II pharmacokinetic interaction study. Cancer Chemother Pharmacol. 2011 Nov;68(5):1111-8. DMS8IFC RU https://www.ncbi.nlm.nih.gov/pubmed/?term=21350850 DMS8IFC DI DMS8IFC DMS8IFC DN Sorafenib DMS8IFC MI DEIBDNY DMS8IFC MN Cytochrome P450 3A5 (CYP3A5) DMS8IFC MT DME DMS8IFC MA Metabolism DMS8IFC RN Drug Interactions Flockhart Table DMS8IFC RU https://drug-interactions.medicine.iu.edu/Main-Table.aspx DMS8IFC DI DMS8IFC DMS8IFC DN Sorafenib DMS8IFC MI DERD86B DMS8IFC MN Cytochrome P450 3A7 (CYP3A7) DMS8IFC MT DME DMS8IFC MA Metabolism DMS8IFC RN Drug Interactions Flockhart Table DMS8IFC RU https://drug-interactions.medicine.iu.edu/Main-Table.aspx DMS8IFC DI DMS8IFC DMS8IFC DN Sorafenib DMS8IFC MI TTGKNB4 DMS8IFC MN Epidermal growth factor receptor (EGFR) DMS8IFC MT DTT DMS8IFC MA Inhibitor DMS8IFC RN Nasopharyngeal carcinoma: Current treatment options and future directions. J Nasopharyng Carcinoma, 2014, 1(16): e16. DMS8IFC RU http://journalofnasopharyngealcarcinoma.org/JNPC/article/view/30/227 DMS8IFC DI DMS8IFC DMS8IFC DN Sorafenib DMS8IFC MI DTFI42L DMS8IFC MN Multidrug resistance-associated protein 2 (ABCC2) DMS8IFC MT DTP DMS8IFC MA Substrate DMS8IFC RN Multidrug resistance protein 2 implicates anticancer drug-resistance to sorafenib. Biol Pharm Bull. 2011;34(3):433-5. DMS8IFC RU https://doi.org/10.1248/bpb.34.433 DMS8IFC DI DMS8IFC DMS8IFC DN Sorafenib DMS8IFC MI DT3D8F0 DMS8IFC MN Organic anion transporting polypeptide 1B1 (SLCO1B1) DMS8IFC MT DTP DMS8IFC MA Substrate DMS8IFC RN Contribution of OATP1B1 and OATP1B3 to the disposition of sorafenib and sorafenib-glucuronide. Clin Cancer Res. 2013 Mar 15;19(6):1458-66. DMS8IFC RU http://www.ncbi.nlm.nih.gov/pubmed/23340295 DMS8IFC DI DMS8IFC DMS8IFC DN Sorafenib DMS8IFC MI DT9C1TS DMS8IFC MN Organic anion transporting polypeptide 1B3 (SLCO1B3) DMS8IFC MT DTP DMS8IFC MA Substrate DMS8IFC RN Contribution of OATP1B1 and OATP1B3 to the disposition of sorafenib and sorafenib-glucuronide. Clin Cancer Res. 2013 Mar 15;19(6):1458-66. DMS8IFC RU http://www.ncbi.nlm.nih.gov/pubmed/23340295 DMS8IFC DI DMS8IFC DMS8IFC DN Sorafenib DMS8IFC MI DTT79CX DMS8IFC MN Organic cation transporter 1 (SLC22A1) DMS8IFC MT DTP DMS8IFC MA Substrate DMS8IFC RN nan DMS8IFC RU nan DMS8IFC DI DMS8IFC DMS8IFC DN Sorafenib DMS8IFC MI DTUGYRD DMS8IFC MN P-glycoprotein 1 (ABCB1) DMS8IFC MT DTP DMS8IFC MA Substrate DMS8IFC RN Breast cancer resistance protein and P-glycoprotein limit sorafenib brain accumulation. Mol Cancer Ther. 2010 Feb;9(2):319-26. DMS8IFC RU http://www.ncbi.nlm.nih.gov/pubmed/20103600 DMS8IFC DI DMS8IFC DMS8IFC DN Sorafenib DMS8IFC MI TTI7421 DMS8IFC MN Platelet-derived growth factor receptor beta (PDGFRB) DMS8IFC MT DTT DMS8IFC MA Modulator DMS8IFC RN Preclinical overview of sorafenib, a multikinase inhibitor that targets both Raf and VEGF and PDGF receptor tyrosine kinase signaling.Mol Cancer Ther.2008 Oct;7(10):3129-40. DMS8IFC RU https://www.ncbi.nlm.nih.gov/pubmed/18852116 DMS8IFC DI DMS8IFC DMS8IFC DN Sorafenib DMS8IFC MI DTYEM9B DMS8IFC MN RalBP1-associated Eps domain-containing protein 2 (RALBP1) DMS8IFC MT DTP DMS8IFC MA Substrate DMS8IFC RN Rlip76 transports sunitinib and sorafenib and mediates drug resistance in kidney cancer. Int J Cancer. 2010 Mar 15;126(6):1327-38. DMS8IFC RU http://www.ncbi.nlm.nih.gov/pubmed/19626587 DMS8IFC DI DMS8IFC DMS8IFC DN Sorafenib DMS8IFC MI TTX41N9 DMS8IFC MN Tyrosine-protein kinase Kit (KIT) DMS8IFC MT DTT DMS8IFC MA Modulator DMS8IFC RN Preclinical overview of sorafenib, a multikinase inhibitor that targets both Raf and VEGF and PDGF receptor tyrosine kinase signaling.Mol Cancer Ther.2008 Oct;7(10):3129-40. DMS8IFC RU https://www.ncbi.nlm.nih.gov/pubmed/18852116 DMS8IFC DI DMS8IFC DMS8IFC DN Sorafenib DMS8IFC MI DE85D2P DMS8IFC MN UDP-glucuronosyltransferase 1A9 (UGT1A9) DMS8IFC MT DME DMS8IFC MA Metabolism DMS8IFC RN Pharmacokinetic interaction involving sorafenib and the calcium-channel blocker felodipine in a patient with hepatocellular carcinoma. Invest New Drugs. 2011 Dec;29(6):1511-4. DMS8IFC RU https://www.ncbi.nlm.nih.gov/pubmed/?term=20706860 DMS8IFC DI DMS8IFC DMS8IFC DN Sorafenib DMS8IFC MI TTUTJGQ DMS8IFC MN Vascular endothelial growth factor receptor 2 (KDR) DMS8IFC MT DTT DMS8IFC MA Modulator DMS8IFC RN Preclinical overview of sorafenib, a multikinase inhibitor that targets both Raf and VEGF and PDGF receptor tyrosine kinase signaling.Mol Cancer Ther.2008 Oct;7(10):3129-40. DMS8IFC RU https://www.ncbi.nlm.nih.gov/pubmed/18852116 DMAN0DE DI DMAN0DE DMAN0DE DN Sorbitol DMAN0DE MI DEWU03P DMAN0DE MN Sorbitol dehydrogenase (SORD) DMAN0DE MT DME DMAN0DE MA Metabolism DMAN0DE RN Plasma concentration of iditol dehydrogenase (sorbitol dehydrogenase) in ponies treated with aflatoxin B1. Am J Vet Res. 1980 Jun;41(6):925-7. DMAN0DE RU https://www.ncbi.nlm.nih.gov/pubmed/?term=7436081 DMUJGR1 DI DMUJGR1 DMUJGR1 DN Sorivudine DMUJGR1 MI TT84ETX DMUJGR1 MN Human immunodeficiency virus Reverse transcriptase (HIV RT) DMUJGR1 MT DTT DMUJGR1 MA Modulator DMUJGR1 RN Natural products as sources of new drugs over the last 25 years. J Nat Prod. 2007 Mar;70(3):461-77. DMUJGR1 RU https://pubmed.ncbi.nlm.nih.gov/17309302 DML60TN DI DML60TN DML60TN DN Sotalol DML60TN MI TTR6W5O DML60TN MN Adrenergic receptor beta-1 (ADRB1) DML60TN MT DTT DML60TN MA Antagonist DML60TN RN beta(2)-adrenoceptors are critical for antidepressant treatment of neuropathic pain. Ann Neurol. 2009 Feb;65(2):218-25. DML60TN RU https://pubmed.ncbi.nlm.nih.gov/19259968 DML60TN DI DML60TN DML60TN DN Sotalol DML60TN MI DECB0K3 DML60TN MN Cytochrome P450 2D6 (CYP2D6) DML60TN MT DME DML60TN MA Metabolism DML60TN RN Application of substrate depletion assay to evaluation of CYP isoforms responsible for stereoselective metabolism of carvedilol. Drug Metab Pharmacokinet. 2016 Dec;31(6):425-432. DML60TN RU https://www.ncbi.nlm.nih.gov/pubmed/?term=27836712 DML60TN DI DML60TN DML60TN DN Sotalol DML60TN MI DTE2B1D DML60TN MN Organic anion transporting polypeptide 1A2 (SLCO1A2) DML60TN MT DTP DML60TN MA Substrate DML60TN RN Involvement of influx and efflux transport systems in gastrointestinal absorption of celiprolol. J Pharm Sci. 2009 Jul;98(7):2529-39. DML60TN RU http://www.ncbi.nlm.nih.gov/pubmed/19067419 DMB4HCT DI DMB4HCT DMB4HCT DN Sparfloxacin DMB4HCT MI TTN6J5F DMB4HCT MN Bacterial DNA gyrase (Bact gyrase) DMB4HCT MT DTT DMB4HCT MA Modulator DMB4HCT RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. DMB4HCT RU https://www.fda.gov/ DMB4HCT DI DMB4HCT DMB4HCT DN Sparfloxacin DMB4HCT MI DTUGYRD DMB4HCT MN P-glycoprotein 1 (ABCB1) DMB4HCT MT DTP DMB4HCT MA Substrate DMB4HCT RN Mammalian drug efflux transporters of the ATP binding cassette (ABC) family in multidrug resistance: A review of the past decade. Cancer Lett. 2016 Jan 1;370(1):153-64. DMB4HCT RU http://www.ncbi.nlm.nih.gov/pubmed/26499806 DMB4HCT DI DMB4HCT DMB4HCT DN Sparfloxacin DMB4HCT MI TTIXTO3 DMB4HCT MN Staphylococcus Topoisomerase IV (Stap-coc parC) DMB4HCT MT DTT DMB4HCT MA Modulator DMB4HCT RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. DMB4HCT RU https://www.fda.gov/ DM6CMJD DI DM6CMJD DM6CMJD DN Spectinomycin DM6CMJD MI DEYWTIQ DM6CMJD MN Aminoglycoside adenylyltransferase (aadA1a) DM6CMJD MT DME DM6CMJD MA Metabolism DM6CMJD RN Structural mechanism of AadA, a dual-specificity aminoglycoside adenylyltransferase from Salmonella enterica. J Biol Chem. 2018 Jul 20;293(29):11481-11490. DM6CMJD RU https://pubmed.ncbi.nlm.nih.gov/29871922 DM0MQ35 DI DM0MQ35 DM0MQ35 DN Spectinomycin DM0MQ35 MI TTQ8KVI DM0MQ35 MN Staphylococcus 30S ribosomal subunit (Stap-coc pbp2) DM0MQ35 MT DTT DM0MQ35 MA Binder DM0MQ35 RN Functional insights from the structure of the 30S ribosomal subunit and its interactions with antibiotics. Nature. 2000 Sep 21;407(6802):340-8. DM0MQ35 RU https://pubmed.ncbi.nlm.nih.gov/11014183 DM6XFHS DI DM6XFHS DM6XFHS DN SPI-1005 DM6XFHS MI TTFNGC9 DM6XFHS MN Serum albumin (ALB) DM6XFHS MT DTT DM6XFHS MA Binder DM6XFHS RN Transport of ebselen in plasma and its transfer to binding sites in the hepatocyte. Biochem Pharmacol. 1994 Sep 15;48(6):1137-44. DM6XFHS RU https://pubmed.ncbi.nlm.nih.gov/7945407 DM0BQRS DI DM0BQRS DM0BQRS DN Spinosad DM0BQRS MI TT9JZPU DM0BQRS MN Pediculus humanus Nicotinic acetylcholine receptor (Pedhc nAChR) DM0BQRS MT DTT DM0BQRS MA Modulator DM0BQRS RN 2011 FDA drug approvals. Nat Rev Drug Discov. 2012 Feb 1;11(2):91-4. DM0BQRS RU https://pubmed.ncbi.nlm.nih.gov/22293555 DM20R5F DI DM20R5F DM20R5F DN Spiramycin DM20R5F MI TTLFGBV DM20R5F MN Bacterial 23S ribosomal RNA (Bact 23S rRNA) DM20R5F MT DTT DM20R5F MA Binder DM20R5F RN The apicoplast as an antimalarial drug target. Drug Resist Updat. 2001 Jun;4(3):145-51. DM20R5F RU https://pubmed.ncbi.nlm.nih.gov/11768328 DM5XLTY DI DM5XLTY DM5XLTY DN Spirapril DM5XLTY MI TTL69WB DM5XLTY MN Angiotensin-converting enzyme (ACE) DM5XLTY MT DTT DM5XLTY MA Inhibitor DM5XLTY RN Central angiotensin II controls alcohol consumption via its AT1 receptor. FASEB J. 2005 Sep;19(11):1474-81. DM5XLTY RU https://pubmed.ncbi.nlm.nih.gov/16126915 DM5XLTY DI DM5XLTY DM5XLTY DN Spirapril DM5XLTY MI DEQMBHW DM5XLTY MN Dipeptidase (pepV) DM5XLTY MT DME DM5XLTY MA Metabolism DM5XLTY RN Characterization and kinetic analysis of enzyme-substrate recognition by three recombinant lactococcal PepVs. Arch Biochem Biophys. 2006 Oct 15;454(2):137-45. DM5XLTY RU https://pubmed.ncbi.nlm.nih.gov/16962986 DM5XLTY DI DM5XLTY DM5XLTY DN Spirapril DM5XLTY MI DT9G7XN DM5XLTY MN Peptide transporter 1 (SLC15A1) DM5XLTY MT DTP DM5XLTY MA Substrate DM5XLTY RN Transport of angiotensin-converting enzyme inhibitors by H+/peptide transporters revisited. J Pharmacol Exp Ther. 2008 Nov;327(2):432-41. DM5XLTY RU http://www.ncbi.nlm.nih.gov/pubmed/18713951 DM5XLTY DI DM5XLTY DM5XLTY DN Spirapril DM5XLTY MI DT8QKNP DM5XLTY MN Peptide transporter 2 (SLC15A2) DM5XLTY MT DTP DM5XLTY MA Substrate DM5XLTY RN Transport of angiotensin-converting enzyme inhibitors by H+/peptide transporters revisited. J Pharmacol Exp Ther. 2008 Nov;327(2):432-41. DM5XLTY RU http://www.ncbi.nlm.nih.gov/pubmed/18713951 DM2AQ5N DI DM2AQ5N DM2AQ5N DN Spironolactone DM2AQ5N MI TT26PHO DM2AQ5N MN Mineralocorticoid receptor (MR) DM2AQ5N MT DTT DM2AQ5N MA Modulator DM2AQ5N RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. DM2AQ5N RU https://www.fda.gov/ DMCO5JZ DI DMCO5JZ DMCO5JZ DN SR141716A DMCO5JZ MI TT6OEDT DMCO5JZ MN Cannabinoid receptor 1 (CB1) DMCO5JZ MT DTT DMCO5JZ MA Antagonist DMCO5JZ RN Anti-obesity drugs. Expert Opin Pharmacother. 2008 Jun;9(8):1339-50. DMCO5JZ RU https://pubmed.ncbi.nlm.nih.gov/18473708 DM6DEK9 DI DM6DEK9 DM6DEK9 DN Stavudine DM6DEK9 MI TT84ETX DM6DEK9 MN Human immunodeficiency virus Reverse transcriptase (HIV RT) DM6DEK9 MT DTT DM6DEK9 MA Inhibitor DM6DEK9 RN Primer unblocking by HIV-1 reverse transcriptase and resistance to nucleoside RT inhibitors (NRTIs). Int J Biochem Cell Biol. 2004 Sep;36(9):1687-705. DM6DEK9 RU https://pubmed.ncbi.nlm.nih.gov/15183338 DMMSDOY DI DMMSDOY DMMSDOY DN Stiripentol DMMSDOY MI DEJGDUW DMMSDOY MN Cytochrome P450 1A2 (CYP1A2) DMMSDOY MT DME DMMSDOY MA Metabolism DMMSDOY RN Stiripentol. Expert Opin Investig Drugs. 2005 Jul;14(7):905-11. DMMSDOY RU https://www.ncbi.nlm.nih.gov/pubmed/?term=16022579 DMMSDOY DI DMMSDOY DMMSDOY DN Stiripentol DMMSDOY MI DE4LYSA DMMSDOY MN Cytochrome P450 3A4 (CYP3A4) DMMSDOY MT DME DMMSDOY MA Metabolism DMMSDOY RN Product characteristics of Diacomit. DMMSDOY RU http://www.ema.europa.eu/docs/en_GB/document_library/EPAR_-_Product_Information/human/000664/WC500036518.pdf DMMSDOY DI DMMSDOY DMMSDOY DN Stiripentol DMMSDOY MI TTEX6LM DMMSDOY MN GABA(A) receptor gamma-3 (GABRG3) DMMSDOY MT DTT DMMSDOY MA Modulator DMMSDOY RN Stiripentol, a putative antiepileptic drug, enhances the duration of opening of GABA-A receptor channels. Epilepsia. 2006 Apr;47(4):704-16. DMMSDOY RU https://pubmed.ncbi.nlm.nih.gov/16650136 DMMSDOY DI DMMSDOY DMMSDOY DN Stiripentol DMMSDOY MI DEGTFWK DMMSDOY MN Mephenytoin 4-hydroxylase (CYP2C19) DMMSDOY MT DME DMMSDOY MA Metabolism DMMSDOY RN FDA Label of Diacomit. The 2020 official website of the U.S. Food and Drug Administration. DMMSDOY RU https://www.accessdata.fda.gov/drugsatfda_docs/label/2018/206709s000,207223s000lbl.pdf DM5JQ0D DI DM5JQ0D DM5JQ0D DN Streptokinase DM5JQ0D MI TTP86E2 DM5JQ0D MN Plasminogen (PLG) DM5JQ0D MT DTT DM5JQ0D MA Activator DM5JQ0D RN Acute anuric renal failure with streptokinase therapy in a patient with acute venous thromboembolic disease and the review of renal side effects of streptokinase. Tuberk Toraks. 2008;56(4):456-61. DM5JQ0D RU https://pubmed.ncbi.nlm.nih.gov/19123085 DMSRXVM DI DMSRXVM DMSRXVM DN Streptomycin DMSRXVM MI DEYWTIQ DMSRXVM MN Aminoglycoside adenylyltransferase (aadA1a) DMSRXVM MT DME DMSRXVM MA Metabolism DMSRXVM RN Structural mechanism of AadA, a dual-specificity aminoglycoside adenylyltransferase from Salmonella enterica. J Biol Chem. 2018 Jul 20;293(29):11481-11490. DMSRXVM RU https://pubmed.ncbi.nlm.nih.gov/29871922 DMSRXVM DI DMSRXVM DMSRXVM DN Streptomycin DMSRXVM MI DEWPAJD DMSRXVM MN Aminoglycoside O-phosphotransferase (aphA6) DMSRXVM MT DME DMSRXVM MA Metabolism DMSRXVM RN Relationship between antimicrobial resistance and aminoglycoside-modifying enzyme gene expressions in Acinetobacter baumannii. Chin Med J (Engl). 2005 Jan 20;118(2):141-5. DMSRXVM RU https://pubmed.ncbi.nlm.nih.gov/15667800 DMSRXVM DI DMSRXVM DMSRXVM DN Streptomycin DMSRXVM MI DE2M583 DMSRXVM MN Endoglucanase Y (EGY) DMSRXVM MT DME DMSRXVM MA Metabolism DMSRXVM RN Expression of Clostridium thermocellum endoglucanase gene in Lactobacillus gasseri and Lactobacillus johnsonii and characterization of the genetically modified probiotic lactobacilli. Curr Microbiol. 2000 Apr;40(4):257-63. DMSRXVM RU https://pubmed.ncbi.nlm.nih.gov/10688695 DMSRXVM DI DMSRXVM DMSRXVM DN Streptomycin DMSRXVM MI DE2AZTG DMSRXVM MN Endoglucanase Y (EGY) DMSRXVM MT DME DMSRXVM MA Metabolism DMSRXVM RN Expression of Clostridium thermocellum endoglucanase gene in Lactobacillus gasseri and Lactobacillus johnsonii and characterization of the genetically modified probiotic lactobacilli. Curr Microbiol. 2000 Apr;40(4):257-63. DMSRXVM RU https://pubmed.ncbi.nlm.nih.gov/10688695 DMSRXVM DI DMSRXVM DMSRXVM DN Streptomycin DMSRXVM MI DEMVXEA DMSRXVM MN Phosphotransferase enzyme strA (strA) DMSRXVM MT DME DMSRXVM MA Metabolism DMSRXVM RN Genetic analysis of streptomycin-resistant (Sm(R)) strains of Erwinia amylovora suggests that dissemination of two genotypes is responsible for the current distribution of Sm(R) E. amylovora in Michigan. Phytopathology. 2011 Feb;101(2):182-91. DMSRXVM RU https://pubmed.ncbi.nlm.nih.gov/20923367 DMSRXVM DI DMSRXVM DMSRXVM DN Streptomycin DMSRXVM MI DEXCHR2 DMSRXVM MN Phosphotransferase enzyme strB (strB) DMSRXVM MT DME DMSRXVM MA Metabolism DMSRXVM RN Genetic analysis of streptomycin-resistant (Sm(R)) strains of Erwinia amylovora suggests that dissemination of two genotypes is responsible for the current distribution of Sm(R) E. amylovora in Michigan. Phytopathology. 2011 Feb;101(2):182-91. DMSRXVM RU https://pubmed.ncbi.nlm.nih.gov/20923367 DME1LQN DI DME1LQN DME1LQN DN Streptomycin DME1LQN MI TTQ8KVI DME1LQN MN Staphylococcus 30S ribosomal subunit (Stap-coc pbp2) DME1LQN MT DTT DME1LQN MA Binder DME1LQN RN Functional insights from the structure of the 30S ribosomal subunit and its interactions with antibiotics. Nature. 2000 Sep 21;407(6802):340-8. DME1LQN RU https://pubmed.ncbi.nlm.nih.gov/11014183 DMOF7AT DI DMOF7AT DMOF7AT DN Streptozocin DMOF7AT MI TTUTN1I DMOF7AT MN Human Deoxyribonucleic acid (hDNA) DMOF7AT MT DTT DMOF7AT MA Breaker DMOF7AT RN Hydrodynamics-based transfection of pancreatic duodenal homeobox 1 DNA improves hyperglycemia and is associated with limited complications in diabe... Endocr J. 2009;56(6):783-90. DMOF7AT RU https://pubmed.ncbi.nlm.nih.gov/19561381 DME81IY DI DME81IY DME81IY DN Succimer DME81IY MI DTFI42L DME81IY MN Multidrug resistance-associated protein 2 (ABCC2) DME81IY MT DTP DME81IY MA Substrate DME81IY RN MRP2 involvement in renal proximal tubular elimination of methylmercury mediated by DMPS or DMSA. Toxicol Appl Pharmacol. 2009 Feb 15;235(1):10-7. DME81IY RU http://www.ncbi.nlm.nih.gov/pubmed/19063911 DMDWICP DI DMDWICP DMDWICP DN Succinic acid DMDWICP MI TTJUWVB DMDWICP MN Succinate-semialdehyde dehydrogenase (ALDH5A1) DMDWICP MT DTT DMDWICP MA Inhibitor DMDWICP RN Redox-switch modulation of human SSADH by dynamic catalytic loop. EMBO J. 2009 Apr 8;28(7):959-68. DMDWICP RU https://pubmed.ncbi.nlm.nih.gov/19300440 DM2ET1M DI DM2ET1M DM2ET1M DN Succinylcholine DM2ET1M MI TTQ13Z5 DM2ET1M MN Muscarinic acetylcholine receptor M3 (CHRM3) DM2ET1M MT DTT DM2ET1M MA Antagonist DM2ET1M RN The involvement of histaminic and muscarinic receptors in the bronchoconstriction induced by myorelaxant administration in sensitized rabbits. Anesth Analg. 2008 Dec;107(6):1899-906. DM2ET1M RU https://pubmed.ncbi.nlm.nih.gov/19020136 DMP9HBO DI DMP9HBO DMP9HBO DN Sucralfate DMP9HBO MI TTGKIED DMP9HBO MN Fibroblast growth factor-2 (FGF2) DMP9HBO MT DTT DMP9HBO MA Modulator DMP9HBO RN Assessment of sucralfate coating by sequential scintigraphic imaging in radiation-induced esophageal lesions. Gastrointest Endosc. 1995 Feb;41(2):109-14. DMP9HBO RU https://pubmed.ncbi.nlm.nih.gov/7720996 DMU7YEL DI DMU7YEL DMU7YEL DN Sufentanil DMU7YEL MI DE4LYSA DMU7YEL MN Cytochrome P450 3A4 (CYP3A4) DMU7YEL MT DME DMU7YEL MA Metabolism DMU7YEL RN Possible involvement of multiple cytochrome P450S in fentanyl and sufentanil metabolism as opposed to alfentanil. Biochem Pharmacol. 1997 Jun 1;53(11):1613-9. DMU7YEL RU https://www.ncbi.nlm.nih.gov/pubmed/?term=9264313 DMU7YEL DI DMU7YEL DMU7YEL DN Sufentanil DMU7YEL MI TTN4QDT DMU7YEL MN Opioid receptor (OPR) DMU7YEL MT DTT DMU7YEL MA Antagonist DMU7YEL RN mu-opioid receptor-stimulated synthesis of reactive oxygen species is mediated via phospholipase D2. J Neurochem. 2009 Aug;110(4):1288-96. DMU7YEL RU https://pubmed.ncbi.nlm.nih.gov/19519662 DMZ6VEY DI DMZ6VEY DMZ6VEY DN Sulfacetamide DMZ6VEY MI TT915ZD DMZ6VEY MN Candida Mannose-6-phosphate isomerase (Candi PMI1) DMZ6VEY MT DTT DMZ6VEY MA Inhibitor DMZ6VEY RN Antifungal Activity of Ag(I) and Zn(II) Complexes of Sulfacetamide Derivatives. Met Based Drugs. 2000;7(1):49-54. DMZ6VEY RU https://pubmed.ncbi.nlm.nih.gov/18475922 DMKI2XC DI DMKI2XC DMKI2XC DN Sulfacytine DMKI2XC MI TT4ILYC DMKI2XC MN Bacterial Dihydropteroate synthetase (Bact folP) DMKI2XC MT DTT DMKI2XC MA Inhibitor DMKI2XC RN Sulfacytine in uncomplicated urinary tract infections. Double-blind comparison with sulfisoxazole. Urology. 1976 Mar;7(3):267-71. DMKI2XC RU https://pubmed.ncbi.nlm.nih.gov/769287 DMTW3R8 DI DMTW3R8 DMTW3R8 DN Sulfadiazine DMTW3R8 MI TT4ILYC DMTW3R8 MN Bacterial Dihydropteroate synthetase (Bact folP) DMTW3R8 MT DTT DMTW3R8 MA Inhibitor DMTW3R8 RN Sulfadiazine/hydroxypropyl-beta-cyclodextrin host-guest system: Characterization, phase-solubility and molecular modeling. Bioorg Med Chem. 2008 May 15;16(10):5788-94. DMTW3R8 RU https://pubmed.ncbi.nlm.nih.gov/18434167 DMTW3R8 DI DMTW3R8 DMTW3R8 DN Sulfadiazine DMTW3R8 MI DES5XRU DMTW3R8 MN Cytochrome P450 2C8 (CYP2C8) DMTW3R8 MT DME DMTW3R8 MA Metabolism DMTW3R8 RN Reduction of sulfamethoxazole and dapsone hydroxylamines by a microsomal enzyme system purified from pig liver and pig and human liver microsomes. Life Sci. 2005 May 27;77(2):205-19. DMTW3R8 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=15862605 DMTW3R8 DI DMTW3R8 DMTW3R8 DN Sulfadiazine DMTW3R8 MI DE5IED8 DMTW3R8 MN Cytochrome P450 2C9 (CYP2C9) DMTW3R8 MT DME DMTW3R8 MA Metabolism DMTW3R8 RN Prediction of in vivo drug-drug interactions between tolbutamide and various sulfonamides in humans based on in vitro experiments. Drug Metab Dispos. 2000 Apr;28(4):475-81. DMTW3R8 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=10725317 DMTW3R8 DI DMTW3R8 DMTW3R8 DN Sulfadiazine DMTW3R8 MI DEVDYN7 DMTW3R8 MN Cytochrome P450 2E1 (CYP2E1) DMTW3R8 MT DME DMTW3R8 MA Metabolism DMTW3R8 RN Summary of information on human CYP enzymes: human P450 metabolism data. Drug Metab Rev. 2002 Feb-May;34(1-2):83-448. DMTW3R8 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=11996015 DMTW3R8 DI DMTW3R8 DMTW3R8 DN Sulfadiazine DMTW3R8 MI DE4LYSA DMTW3R8 MN Cytochrome P450 3A4 (CYP3A4) DMTW3R8 MT DME DMTW3R8 MA Metabolism DMTW3R8 RN Summary of information on human CYP enzymes: human P450 metabolism data. Drug Metab Rev. 2002 Feb-May;34(1-2):83-448. DMTW3R8 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=11996015 DMTW3R8 DI DMTW3R8 DMTW3R8 DN Sulfadiazine DMTW3R8 MI DEZV4AP DMTW3R8 MN RNA cytidine acetyltransferase (hALP) DMTW3R8 MT DME DMTW3R8 MA Metabolism DMTW3R8 RN Identification of cytochrome P450 and arylamine N-acetyltransferase isoforms involved in sulfadiazine metabolism. Drug Metab Dispos. 2005 Jul;33(7):969-76. DMTW3R8 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=15843491 DMKM3SX DI DMKM3SX DMKM3SX DN Sulfamerazine DMKM3SX MI TT4ILYC DMKM3SX MN Bacterial Dihydropteroate synthetase (Bact folP) DMKM3SX MT DTT DMKM3SX MA Inhibitor DMKM3SX RN A confirmatory method for the simultaneous extraction, separation, identification and quantification of Tetracycline, Sulphonamide, Trimethoprim an... J Chromatogr A. 2009 Nov 13;1216(46):8110-6. DMKM3SX RU https://pubmed.ncbi.nlm.nih.gov/19586630 DMRGZ16 DI DMRGZ16 DMRGZ16 DN Sulfamethazine DMRGZ16 MI TT4ILYC DMRGZ16 MN Bacterial Dihydropteroate synthetase (Bact folP) DMRGZ16 MT DTT DMRGZ16 MA Inhibitor DMRGZ16 RN A new and simple method to determine trace levels of sulfonamides in honey by high performance liquid chromatography with fluorescence detection. J Chromatogr A. 2009 Oct 23;1216(43):7275-80. DMRGZ16 RU https://pubmed.ncbi.nlm.nih.gov/19505691 DMGCHDS DI DMGCHDS DMGCHDS DN Sulfamethizole DMGCHDS MI TT4ILYC DMGCHDS MN Bacterial Dihydropteroate synthetase (Bact folP) DMGCHDS MT DTT DMGCHDS MA Inhibitor DMGCHDS RN Inhibition of bioluminescence in Photobacterium phosphoreum by sulfamethizole and its stimulation by thymine. Biochim Biophys Acta. 1990 Jun 26;1017(3):229-34. DMGCHDS RU https://pubmed.ncbi.nlm.nih.gov/2372557 DMB08GE DI DMB08GE DMB08GE DN Sulfamethoxazole DMB08GE MI TT4ILYC DMB08GE MN Bacterial Dihydropteroate synthetase (Bact folP) DMB08GE MT DTT DMB08GE MA Inhibitor DMB08GE RN In vitro activities of novel antifolate drug combinations against Plasmodium falciparum and human granulocyte CFUs. Antimicrob Agents Chemother. 1995 Apr;39(4):948-52. DMB08GE RU https://pubmed.ncbi.nlm.nih.gov/7786001 DMB08GE DI DMB08GE DMB08GE DN Sulfamethoxazole DMB08GE MI DES5XRU DMB08GE MN Cytochrome P450 2C8 (CYP2C8) DMB08GE MT DME DMB08GE MA Metabolism DMB08GE RN Sulfamethoxazole and its metabolite nitroso sulfamethoxazole stimulate dendritic cell costimulatory signaling. J Immunol. 2007 May 1;178(9):5533-42. DMB08GE RU https://www.ncbi.nlm.nih.gov/pubmed/?term=17442935 DMB08GE DI DMB08GE DMB08GE DN Sulfamethoxazole DMB08GE MI DE5IED8 DMB08GE MN Cytochrome P450 2C9 (CYP2C9) DMB08GE MT DME DMB08GE MA Metabolism DMB08GE RN Reduction of sulfamethoxazole and dapsone hydroxylamines by a microsomal enzyme system purified from pig liver and pig and human liver microsomes. Life Sci. 2005 May 27;77(2):205-19. DMB08GE RU https://www.ncbi.nlm.nih.gov/pubmed/?term=15862605 DMB08GE DI DMB08GE DMB08GE DN Sulfamethoxazole DMB08GE MI DE4LYSA DMB08GE MN Cytochrome P450 3A4 (CYP3A4) DMB08GE MT DME DMB08GE MA Metabolism DMB08GE RN The effect of cimetidine on the formation of sulfamethoxazole hydroxylamine in patients with human immunodeficiency virus. J Clin Pharmacol. 1998 May;38(5):463-6. DMB08GE RU https://www.ncbi.nlm.nih.gov/pubmed/?term=9602961 DMB08GE DI DMB08GE DMB08GE DN Sulfamethoxazole DMB08GE MI DE073H6 DMB08GE MN Prostaglandin G/H synthase 1 (COX-1) DMB08GE MT DME DMB08GE MA Metabolism DMB08GE RN Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. DMB08GE RU https://www.ncbi.nlm.nih.gov/pubmed/?term=19515014 DMB08GE DI DMB08GE DMB08GE DN Sulfamethoxazole DMB08GE MI DEZV4AP DMB08GE MN RNA cytidine acetyltransferase (hALP) DMB08GE MT DME DMB08GE MA Metabolism DMB08GE RN Crystallization and preliminary X-ray characterization of arylamine N-acetyltransferase C (BanatC) from Bacillus anthracis. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2007 Oct 1;63(Pt 10):862-4. DMB08GE RU https://www.ncbi.nlm.nih.gov/pubmed/?term=17909290 DMB08GE DI DMB08GE DMB08GE DN Sulfamethoxazole DMB08GE MI DE85D2P DMB08GE MN UDP-glucuronosyltransferase 1A9 (UGT1A9) DMB08GE MT DME DMB08GE MA Metabolism DMB08GE RN Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. DMB08GE RU https://www.ncbi.nlm.nih.gov/pubmed/?term=19515014 DMIO1K0 DI DMIO1K0 DMIO1K0 DN Sulfamylon DMIO1K0 MI TTUNARX DMIO1K0 MN Carbonic anhydrase (CA) DMIO1K0 MT DTT DMIO1K0 MA Inhibitor DMIO1K0 RN Cloning, expression, post-translational modifications and inhibition studies on the latest mammalian carbonic anhydrase isoform, CA XV. J Med Chem. 2009 Feb 12;52(3):646-54. DMIO1K0 RU https://pubmed.ncbi.nlm.nih.gov/19193158 DMIO1K0 DI DMIO1K0 DMIO1K0 DN Sulfamylon DMIO1K0 MI TTANPDJ DMIO1K0 MN Carbonic anhydrase II (CA-II) DMIO1K0 MT DTT DMIO1K0 MA Inhibitor DMIO1K0 RN Sulfonamide linked neoglycoconjugates--a new class of inhibitors for cancer-associated carbonic anhydrases. J Med Chem. 2010 Apr 8;53(7):2913-26. DMIO1K0 RU https://pubmed.ncbi.nlm.nih.gov/20201556 DMIO1K0 DI DMIO1K0 DMIO1K0 DN Sulfamylon DMIO1K0 MI TTZHA0O DMIO1K0 MN Carbonic anhydrase IV (CA-IV) DMIO1K0 MT DTT DMIO1K0 MA Inhibitor DMIO1K0 RN Carbonic anhydrase inhibitors. Inhibition of the membrane-bound human and bovine isozymes IV with sulfonamides. Bioorg Med Chem Lett. 2005 Feb 15;15(4):1149-54. DMIO1K0 RU https://pubmed.ncbi.nlm.nih.gov/15686931 DMIO1K0 DI DMIO1K0 DMIO1K0 DN Sulfamylon DMIO1K0 MI TTCFSPE DMIO1K0 MN Carbonic anhydrase VI (CA-VI) DMIO1K0 MT DTT DMIO1K0 MA Inhibitor DMIO1K0 RN Cloning, expression, post-translational modifications and inhibition studies on the latest mammalian carbonic anhydrase isoform, CA XV. J Med Chem. 2009 Feb 12;52(3):646-54. DMIO1K0 RU https://pubmed.ncbi.nlm.nih.gov/19193158 DMIO1K0 DI DMIO1K0 DMIO1K0 DN Sulfamylon DMIO1K0 MI TTSYM0R DMIO1K0 MN Carbonic anhydrase XII (CA-XII) DMIO1K0 MT DTT DMIO1K0 MA Inhibitor DMIO1K0 RN Sulfonamide linked neoglycoconjugates--a new class of inhibitors for cancer-associated carbonic anhydrases. J Med Chem. 2010 Apr 8;53(7):2913-26. DMIO1K0 RU https://pubmed.ncbi.nlm.nih.gov/20201556 DMIO1K0 DI DMIO1K0 DMIO1K0 DN Sulfamylon DMIO1K0 MI TTEYTKG DMIO1K0 MN Carbonic anhydrase XIV (CA-XIV) DMIO1K0 MT DTT DMIO1K0 MA Inhibitor DMIO1K0 RN Carbonic anhydrase inhibitors: inhibition of the transmembrane isozyme XIV with sulfonamides. Bioorg Med Chem Lett. 2005 Sep 1;15(17):3828-33. DMIO1K0 RU https://pubmed.ncbi.nlm.nih.gov/16039848 DMABVE9 DI DMABVE9 DMABVE9 DN Sulfanilamide DMABVE9 MI TT4ILYC DMABVE9 MN Bacterial Dihydropteroate synthetase (Bact folP) DMABVE9 MT DTT DMABVE9 MA Modulator DMABVE9 RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. DMABVE9 RU https://www.fda.gov/ DMFNAEM DI DMFNAEM DMFNAEM DN Sulfaphenazole DMFNAEM MI TTR40YJ DMFNAEM MN S-mephenytoin 4-hydroxylase (CYP2C9) DMFNAEM MT DTT DMFNAEM MA Modulator DMFNAEM RN Identification of amino acid substitutions that confer a high affinity for sulfaphenazole binding and a high catalytic efficiency for warfarin meta... Biochemistry. 1998 Nov 17;37(46):16270-9. DMFNAEM RU https://www.ncbi.nlm.nih.gov/pubmed/9819219 DMIUYFH DI DMIUYFH DMIUYFH DN Sulfapyridine DMIUYFH MI TT4ILYC DMIUYFH MN Bacterial Dihydropteroate synthetase (Bact folP) DMIUYFH MT DTT DMIUYFH MA Inhibitor DMIUYFH RN A confirmatory method for the simultaneous extraction, separation, identification and quantification of Tetracycline, Sulphonamide, Trimethoprim an... J Chromatogr A. 2009 Nov 13;1216(46):8110-6. DMIUYFH RU https://pubmed.ncbi.nlm.nih.gov/19586630 DMIUYFH DI DMIUYFH DMIUYFH DN Sulfapyridine DMIUYFH MI DEZV4AP DMIUYFH MN RNA cytidine acetyltransferase (hALP) DMIUYFH MT DME DMIUYFH MA Metabolism DMIUYFH RN Effects of NAT2 polymorphism on SASP pharmacokinetics in Chinese population. Clin Chim Acta. 2009 Sep;407(1-2):30-5. DMIUYFH RU https://www.ncbi.nlm.nih.gov/pubmed/?term=19560446 DMICA9H DI DMICA9H DMICA9H DN Sulfasalazine DMICA9H MI TTIMJ02 DMICA9H MN ATP-binding cassette transporter G2 (ABCG2) DMICA9H MT DTT DMICA9H MA Inhibitor DMICA9H RN The anti-inflammatory mechanism of sulfasalazine is related to adenosine release at inflamed sites. J Immunol. 1996 Mar 1;156(5):1937-41. DMICA9H RU https://pubmed.ncbi.nlm.nih.gov/8596047 DMICA9H DI DMICA9H DMICA9H DN Sulfasalazine DMICA9H MI DE5CAX1 DMICA9H MN Azoreductase (azoR) DMICA9H MT DME DMICA9H MA Metabolism DMICA9H RN The influence of probiotic treatment on sulfasalazine metabolism in rat. Xenobiotica. 2012 Aug;42(8):791-7. DMICA9H RU https://pubmed.ncbi.nlm.nih.gov/22348441 DMICA9H DI DMICA9H DMICA9H DN Sulfasalazine DMICA9H MI DEGTKHL DMICA9H MN Azoreductase (azoR) DMICA9H MT DME DMICA9H MA Metabolism DMICA9H RN The role of intestinal bacteria in the metabolism of salicylazosulfapyridine. J Pharmacol Exp Ther. 1972 Jun;181(3):555-62. DMICA9H RU https://pubmed.ncbi.nlm.nih.gov/4402374 DMICA9H DI DMICA9H DMICA9H DN Sulfasalazine DMICA9H MI DE3UF6Z DMICA9H MN Azoreductase (azoR) DMICA9H MT DME DMICA9H MA Metabolism DMICA9H RN The role of intestinal bacteria in the metabolism of salicylazosulfapyridine. J Pharmacol Exp Ther. 1972 Jun;181(3):555-62. DMICA9H RU https://pubmed.ncbi.nlm.nih.gov/4402374 DMICA9H DI DMICA9H DMICA9H DN Sulfasalazine DMICA9H MI DE6GHJ5 DMICA9H MN Azoreductase (azoR) DMICA9H MT DME DMICA9H MA Metabolism DMICA9H RN The role of intestinal bacteria in the metabolism of salicylazosulfapyridine. J Pharmacol Exp Ther. 1972 Jun;181(3):555-62. DMICA9H RU https://pubmed.ncbi.nlm.nih.gov/4402374 DMICA9H DI DMICA9H DMICA9H DN Sulfasalazine DMICA9H MI DEEISQ2 DMICA9H MN Azoreductase (azoR) DMICA9H MT DME DMICA9H MA Metabolism DMICA9H RN The influence of probiotic treatment on sulfasalazine metabolism in rat. Xenobiotica. 2012 Aug;42(8):791-7. DMICA9H RU https://pubmed.ncbi.nlm.nih.gov/22348441 DMICA9H DI DMICA9H DMICA9H DN Sulfasalazine DMICA9H MI DEI2PC5 DMICA9H MN Azoreductase (azoR) DMICA9H MT DME DMICA9H MA Metabolism DMICA9H RN The influence of probiotic treatment on sulfasalazine metabolism in rat. Xenobiotica. 2012 Aug;42(8):791-7. DMICA9H RU https://pubmed.ncbi.nlm.nih.gov/22348441 DMICA9H DI DMICA9H DMICA9H DN Sulfasalazine DMICA9H MI DETEMAH DMICA9H MN Azoreductase (azoR) DMICA9H MT DME DMICA9H MA Metabolism DMICA9H RN The role of intestinal bacteria in the metabolism of salicylazosulfapyridine. J Pharmacol Exp Ther. 1972 Jun;181(3):555-62. DMICA9H RU https://pubmed.ncbi.nlm.nih.gov/4402374 DMICA9H DI DMICA9H DMICA9H DN Sulfasalazine DMICA9H MI DEM1BHT DMICA9H MN Azoreductase (azoR) DMICA9H MT DME DMICA9H MA Metabolism DMICA9H RN The influence of probiotic treatment on sulfasalazine metabolism in rat. Xenobiotica. 2012 Aug;42(8):791-7. DMICA9H RU https://pubmed.ncbi.nlm.nih.gov/22348441 DMICA9H DI DMICA9H DMICA9H DN Sulfasalazine DMICA9H MI DEIKZOU DMICA9H MN Azoreductase (azoR) DMICA9H MT DME DMICA9H MA Metabolism DMICA9H RN Mapping human microbiome drug metabolism by gut bacteria and their genes. Nature. 2019 Jun;570(7762):462-467. DMICA9H RU https://pubmed.ncbi.nlm.nih.gov/31158845 DMICA9H DI DMICA9H DMICA9H DN Sulfasalazine DMICA9H MI DENLBG3 DMICA9H MN Azoreductase (azoR) DMICA9H MT DME DMICA9H MA Metabolism DMICA9H RN The influence of probiotic treatment on sulfasalazine metabolism in rat. Xenobiotica. 2012 Aug;42(8):791-7. DMICA9H RU https://pubmed.ncbi.nlm.nih.gov/22348441 DMICA9H DI DMICA9H DMICA9H DN Sulfasalazine DMICA9H MI DEIHK8V DMICA9H MN Azoreductase (azoR) DMICA9H MT DME DMICA9H MA Metabolism DMICA9H RN The influence of probiotic treatment on sulfasalazine metabolism in rat. Xenobiotica. 2012 Aug;42(8):791-7. 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DMICA9H RU https://pubmed.ncbi.nlm.nih.gov/18321156 DMICA9H DI DMICA9H DMICA9H DN Sulfasalazine DMICA9H MI DTPFTEQ DMICA9H MN Organic anion transporting polypeptide 2B1 (SLCO2B1) DMICA9H MT DTP DMICA9H MA Substrate DMICA9H RN Small-Dosing Clinical Study: Pharmacokinetic, Pharmacogenomic (SLCO2B1 and ABCG2), and Interaction (Atorvastatin and Grapefruit Juice) Profiles of 5 Probes for OATP2B1 and BCRP. J Pharm Sci. 2017 Sep;106(9):2688-2694. DMICA9H RU http://www.ncbi.nlm.nih.gov/pubmed/28322941 DMICA9H DI DMICA9H DMICA9H DN Sulfasalazine DMICA9H MI DT9G7XN DMICA9H MN Peptide transporter 1 (SLC15A1) DMICA9H MT DTP DMICA9H MA Substrate DMICA9H RN Peptide transporter substrate identification during permeability screening in drug discovery: comparison of transfected MDCK-hPepT1 cells to Caco-2 cells. Arch Pharm Res. 2007 Apr;30(4):507-18. 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DM2QHZU RU https://pubmed.ncbi.nlm.nih.gov/6409111 DM2QHZU DI DM2QHZU DM2QHZU DN Sulindac DM2QHZU MI DTCSGPB DM2QHZU MN Multidrug resistance-associated protein 4 (ABCC4) DM2QHZU MT DTP DM2QHZU MA Substrate DM2QHZU RN Fluo-cAMP is transported by multidrug resistance-associated protein isoform 4 in rat choroid plexus. J Neurochem. 2010 Oct;115(1):200-8. DM2QHZU RU http://www.ncbi.nlm.nih.gov/pubmed/20649844 DMNUC42 DI DMNUC42 DMNUC42 DN Sulodexide DMNUC42 MI TT4QPUL DMNUC42 MN Antithrombin-III (ATIII) DMNUC42 MT DTT DMNUC42 MA Activator DMNUC42 RN Review of pharmacodynamics, pharmacokinetics, and therapeutic properties of sulodexide. Med Res Rev. 1998 Jan;18(1):1-20. DMNUC42 RU https://pubmed.ncbi.nlm.nih.gov/9436179 DMZI2UF DI DMZI2UF DMZI2UF DN Sulphadoxine DMZI2UF MI TT4ILYC DMZI2UF MN Bacterial Dihydropteroate synthetase (Bact folP) DMZI2UF MT DTT DMZI2UF MA Binder DMZI2UF RN The fight against drug-resistant malaria: novel plasmodial targets and antimalarial drugs. 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DMVYXR8 RU https://pubmed.ncbi.nlm.nih.gov/11293643 DMVYXR8 DI DMVYXR8 DMVYXR8 DN Sumatriptan DMVYXR8 MI DTT79CX DMVYXR8 MN Organic cation transporter 1 (SLC22A1) DMVYXR8 MT DTP DMVYXR8 MA Substrate DMVYXR8 RN Identification of novel substrates and structure-activity relationship of cellular uptake mediated by human organic cation transporters 1 and 2. J Med Chem. 2013 Sep 26;56(18):7232-42. DMVYXR8 RU http://www.ncbi.nlm.nih.gov/pubmed/23984907 DMVYXR8 DI DMVYXR8 DMVYXR8 DN Sumatriptan DMVYXR8 MI DTUGYRD DMVYXR8 MN P-glycoprotein 1 (ABCB1) DMVYXR8 MT DTP DMVYXR8 MA Substrate DMVYXR8 RN HT29-MTX and Caco-2/TC7 monolayers as predictive models for human intestinal absorption: role of the mucus layer. J Pharm Sci. 2001 Oct;90(10):1608-19. Comparative Study DMVYXR8 RU http://www.ncbi.nlm.nih.gov/pubmed/11745719 DMCBJSR DI DMCBJSR DMCBJSR DN Sunitinib DMCBJSR MI DTI7UX6 DMCBJSR MN Breast cancer resistance protein (ABCG2) DMCBJSR MT DTP DMCBJSR MA Substrate DMCBJSR RN Double-transduced MDCKII cells to study human P-glycoprotein (ABCB1) and breast cancer resistance protein (ABCG2) interplay in drug transport across the blood-brain barrier. Mol Pharm. 2011 Apr 4;8(2):571-82. DMCBJSR RU https://doi.org/10.1021/mp1003898 DMCBJSR DI DMCBJSR DMCBJSR DN Sunitinib DMCBJSR MI DE4LYSA DMCBJSR MN Cytochrome P450 3A4 (CYP3A4) DMCBJSR MT DME DMCBJSR MA Metabolism DMCBJSR RN In vitro assessment of time-dependent inhibitory effects on CYP2C8 and CYP3A activity by fourteen protein kinase inhibitors. Drug Metab Dispos. 2014 Jul;42(7):1202-9. 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DMCBJSR RU http://www.ncbi.nlm.nih.gov/pubmed/23340295 DMCBJSR DI DMCBJSR DMCBJSR DN Sunitinib DMCBJSR MI DT9C1TS DMCBJSR MN Organic anion transporting polypeptide 1B3 (SLCO1B3) DMCBJSR MT DTP DMCBJSR MA Substrate DMCBJSR RN Contribution of OATP1B1 and OATP1B3 to the disposition of sorafenib and sorafenib-glucuronide. Clin Cancer Res. 2013 Mar 15;19(6):1458-66. DMCBJSR RU http://www.ncbi.nlm.nih.gov/pubmed/23340295 DMCBJSR DI DMCBJSR DMCBJSR DN Sunitinib DMCBJSR MI DTUGYRD DMCBJSR MN P-glycoprotein 1 (ABCB1) DMCBJSR MT DTP DMCBJSR MA Substrate DMCBJSR RN Interaction of the multikinase inhibitors sorafenib and sunitinib with solute carriers and ATP-binding cassette transporters. Clin Cancer Res. 2009 Oct 1;15(19):6062-9. DMCBJSR RU http://www.ncbi.nlm.nih.gov/pubmed/19773380 DMCBJSR DI DMCBJSR DMCBJSR DN Sunitinib DMCBJSR MI DTYEM9B DMCBJSR MN RalBP1-associated Eps domain-containing protein 2 (RALBP1) DMCBJSR MT DTP DMCBJSR MA Substrate DMCBJSR RN Rlip76 transports sunitinib and sorafenib and mediates drug resistance in kidney cancer. Int J Cancer. 2010 Mar 15;126(6):1327-38. DMCBJSR RU http://www.ncbi.nlm.nih.gov/pubmed/19626587 DMCBJSR DI DMCBJSR DMCBJSR DN Sunitinib DMCBJSR MI TTUTJGQ DMCBJSR MN Vascular endothelial growth factor receptor 2 (KDR) DMCBJSR MT DTT DMCBJSR MA Modulator DMCBJSR RN 2006 drug approvals: finding the niche. Nat Rev Drug Discov. 2007 Feb;6(2):99-101. DMCBJSR RU https://pubmed.ncbi.nlm.nih.gov/17342860 DMN8E5D DI DMN8E5D DMN8E5D DN Sunitinib malate DMN8E5D MI DTUGYRD DMN8E5D MN P-glycoprotein 1 (ABCB1) DMN8E5D MT DTP DMN8E5D MA Substrate DMN8E5D RN JNK-AKT-NF-kB controls P-glycoprotein expression to attenuate the cytotoxicity of deoxynivalenol in mammalian cells. 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DMKXJZ7 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=14570769 DMKXJZ7 DI DMKXJZ7 DMKXJZ7 DN Suprofen DMKXJZ7 MI TT8NGED DMKXJZ7 MN Prostaglandin G/H synthase 1 (COX-1) DMKXJZ7 MT DTT DMKXJZ7 MA Inhibitor DMKXJZ7 RN Differential binding mode of diverse cyclooxygenase inhibitors. J Mol Graph Model. 2002 Mar;20(5):359-71. DMKXJZ7 RU https://pubmed.ncbi.nlm.nih.gov/11885959 DMKXJZ7 DI DMKXJZ7 DMKXJZ7 DN Suprofen DMKXJZ7 MI DEYGVN4 DMKXJZ7 MN UDP-glucuronosyltransferase 1A1 (UGT1A1) DMKXJZ7 MT DME DMKXJZ7 MA Metabolism DMKXJZ7 RN Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. DMKXJZ7 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=19515014 DM0E6S3 DI DM0E6S3 DM0E6S3 DN Suvorexant DM0E6S3 MI DE4LYSA DM0E6S3 MN Cytochrome P450 3A4 (CYP3A4) DM0E6S3 MT DME DM0E6S3 MA Metabolism DM0E6S3 RN Suvorexant: a promising, novel treatment for insomnia. 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DM6S0HB RU https://pubmed.ncbi.nlm.nih.gov/21510312 DM51FY6 DI DM51FY6 DM51FY6 DN Tacrine DM51FY6 MI TT1RS9F DM51FY6 MN Acetylcholinesterase (AChE) DM51FY6 MT DTT DM51FY6 MA Inhibitor DM51FY6 RN Evidence that the clinical effects of cholinesterase inhibitors are related to potency and targeting of action. Int J Clin Pract Suppl. 2002 Jun;(127):6-19. DM51FY6 RU https://pubmed.ncbi.nlm.nih.gov/12139368 DM51FY6 DI DM51FY6 DM51FY6 DN Tacrine DM51FY6 MI DEJGDUW DM51FY6 MN Cytochrome P450 1A2 (CYP1A2) DM51FY6 MT DME DM51FY6 MA Metabolism DM51FY6 RN Synthetic and natural compounds that interact with human cytochrome P450 1A2 and implications in drug development. Curr Med Chem. 2009;16(31):4066-218. DM51FY6 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=19754423 DM51FY6 DI DM51FY6 DM51FY6 DN Tacrine DM51FY6 MI DE4ZHS1 DM51FY6 MN Glutathione S-transferase alpha-1 (GSTA1) DM51FY6 MT DME DM51FY6 MA Metabolism DM51FY6 RN Combined glutathione-S-transferase M1 and T1 genetic polymorphism and tacrine hepatotoxicity. Clin Pharmacol Ther. 2000 Apr;67(4):432-7. DM51FY6 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=10801254 DM51FY6 DI DM51FY6 DM51FY6 DN Tacrine DM51FY6 MI DTUGYRD DM51FY6 MN P-glycoprotein 1 (ABCB1) DM51FY6 MT DTP DM51FY6 MA Substrate DM51FY6 RN Tacrine sinusoidal uptake and biliary excretion in sandwich-cultured primary rat hepatocytes. J Pharm Pharm Sci. 2014;17(3):427-38. DM51FY6 RU http://www.ncbi.nlm.nih.gov/pubmed/25224352 DMZ7XNQ DI DMZ7XNQ DMZ7XNQ DN Tacrolimus DMZ7XNQ MI TTA4LDE DMZ7XNQ MN Calcineurin (PPP3CA) DMZ7XNQ MT DTT DMZ7XNQ MA Inhibitor DMZ7XNQ RN Emerging drugs for ocular allergy. Expert Opin Emerg Drugs. 2005 Aug;10(3):505-20. DMZ7XNQ RU https://pubmed.ncbi.nlm.nih.gov/16083326 DMZ7XNQ DI DMZ7XNQ DMZ7XNQ DN Tacrolimus DMZ7XNQ MI DE4LYSA DMZ7XNQ MN Cytochrome P450 3A4 (CYP3A4) DMZ7XNQ MT DME DMZ7XNQ MA Metabolism DMZ7XNQ RN Summary of information on human CYP enzymes: human P450 metabolism data. Drug Metab Rev. 2002 Feb-May;34(1-2):83-448. DMZ7XNQ RU https://www.ncbi.nlm.nih.gov/pubmed/?term=11996015 DMZ7XNQ DI DMZ7XNQ DMZ7XNQ DN Tacrolimus DMZ7XNQ MI DEIBDNY DMZ7XNQ MN Cytochrome P450 3A5 (CYP3A5) DMZ7XNQ MT DME DMZ7XNQ MA Metabolism DMZ7XNQ RN Tacrolimus pharmacokinetics and pharmacogenetics: influence of adenosine triphosphate-binding cassette B1 (ABCB1) and cytochrome (CYP) 3A polymorphisms. Fundam Clin Pharmacol. 2007 Aug;21(4):427-35. DMZ7XNQ RU https://www.ncbi.nlm.nih.gov/pubmed/?term=17635182 DMZ7XNQ DI DMZ7XNQ DMZ7XNQ DN Tacrolimus DMZ7XNQ MI DE3N2FM DMZ7XNQ MN NADPH-cytochrome P450 reductase (CPR) DMZ7XNQ MT DME DMZ7XNQ MA Metabolism DMZ7XNQ RN Polymorphisms in cytochrome P450 oxidoreductase and its effect on drug metabolism and efficacy. Pharmacogenet Genomics. 2017 Sep;27(9):337-346. DMZ7XNQ RU https://www.ncbi.nlm.nih.gov/pubmed/?term=28731962 DMZ7XNQ DI DMZ7XNQ DMZ7XNQ DN Tacrolimus DMZ7XNQ MI DTUGYRD DMZ7XNQ MN P-glycoprotein 1 (ABCB1) DMZ7XNQ MT DTP DMZ7XNQ MA Substrate DMZ7XNQ RN Mammalian drug efflux transporters of the ATP binding cassette (ABC) family in multidrug resistance: A review of the past decade. Cancer Lett. 2016 Jan 1;370(1):153-64. DMZ7XNQ RU http://www.ncbi.nlm.nih.gov/pubmed/26499806 DMZ7XNQ DI DMZ7XNQ DMZ7XNQ DN Tacrolimus DMZ7XNQ MI DEW6V07 DMZ7XNQ MN Ribosomal 23S RNA methyltransferase Erm (erm) DMZ7XNQ MT DME DMZ7XNQ MA Metabolism DMZ7XNQ RN High frequency of macrolide resistance mechanisms in clinical isolates of Corynebacterium species. Microb Drug Resist. 2010 Dec;16(4):273-7. DMZ7XNQ RU https://pubmed.ncbi.nlm.nih.gov/20624090 DMZ7XNQ DI DMZ7XNQ DMZ7XNQ DN Tacrolimus DMZ7XNQ MI DEA65D8 DMZ7XNQ MN Ribosomal 23S RNA methyltransferase Erm (erm) DMZ7XNQ MT DME DMZ7XNQ MA Metabolism DMZ7XNQ RN High frequency of macrolide resistance mechanisms in clinical isolates of Corynebacterium species. Microb Drug Resist. 2010 Dec;16(4):273-7. DMZ7XNQ RU https://pubmed.ncbi.nlm.nih.gov/20624090 DMJZHT1 DI DMJZHT1 DMJZHT1 DN Tadalafil DMJZHT1 MI DE4LYSA DMJZHT1 MN Cytochrome P450 3A4 (CYP3A4) DMJZHT1 MT DME DMJZHT1 MA Metabolism DMJZHT1 RN Contribution of CYP3A isoforms to dealkylation of PDE5 inhibitors: a comparison between sildenafil N-demethylation and tadalafil demethylenation. Biol Pharm Bull. 2015;38(1):58-65. DMJZHT1 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=25744459 DMJZHT1 DI DMJZHT1 DMJZHT1 DN Tadalafil DMJZHT1 MI DEIBDNY DMJZHT1 MN Cytochrome P450 3A5 (CYP3A5) DMJZHT1 MT DME DMJZHT1 MA Metabolism DMJZHT1 RN Contribution of CYP3A isoforms to dealkylation of PDE5 inhibitors: a comparison between sildenafil N-demethylation and tadalafil demethylenation. Biol Pharm Bull. 2015;38(1):58-65. DMJZHT1 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=25744459 DMJZHT1 DI DMJZHT1 DMJZHT1 DN Tadalafil DMJZHT1 MI DTUGYRD DMJZHT1 MN P-glycoprotein 1 (ABCB1) DMJZHT1 MT DTP DMJZHT1 MA Substrate DMJZHT1 RN In Vitro P-Glycoprotein-Mediated Transport of Tadalafil: A Comparison with Sildenafil. Biol Pharm Bull. 2017;40(8):1314-1319. DMJZHT1 RU http://www.ncbi.nlm.nih.gov/pubmed/28769012 DMJZHT1 DI DMJZHT1 DMJZHT1 DN Tadalafil DMJZHT1 MI TTJ0IQB DMJZHT1 MN Phosphodiesterase 5A (PDE5A) DMJZHT1 MT DTT DMJZHT1 MA Inhibitor DMJZHT1 RN Pulmonary arterial hypertension: the most devastating vascular complication of systemic sclerosis. Rheumatology (Oxford). 2009 Jun;48 Suppl 3:iii25-31. DMJZHT1 RU https://pubmed.ncbi.nlm.nih.gov/19487219 DM1XT4N DI DM1XT4N DM1XT4N DN Tafenoquine DM1XT4N MI DECB0K3 DM1XT4N MN Cytochrome P450 2D6 (CYP2D6) DM1XT4N MT DME DM1XT4N MA Metabolism DM1XT4N RN Tafenoquine and its potential in the treatment and relapse prevention of Plasmodium vivax malaria: the evidence to date. Drug Des Devel Ther. 2016 Jul 26;10:2387-99. DM1XT4N RU https://www.ncbi.nlm.nih.gov/pubmed/?term=27528800 DM1XT4N DI DM1XT4N DM1XT4N DN Tafenoquine DM1XT4N MI TTB8JQ7 DM1XT4N MN Electron transport complex III (Complex III) DM1XT4N MT DTT DM1XT4N MA Inhibitor DM1XT4N RN Tafenoquine: First Global Approval.Drugs. 2018 Sep;78(14):1517-1523. DM1XT4N RU https://pubmed.ncbi.nlm.nih.gov/30229442 DM1XT4N DI DM1XT4N DM1XT4N DN Tafenoquine DM1XT4N MI TTULV0X DM1XT4N MN Reactive oxygen species (ROS) DM1XT4N MT DTT DM1XT4N MA Modulator DM1XT4N RN Tafenoquine: First Global Approval.Drugs. 2018 Sep;78(14):1517-1523. DM1XT4N RU https://pubmed.ncbi.nlm.nih.gov/30229442 DMFC41K DI DMFC41K DMFC41K DN Tafluprost DMFC41K MI TTT2ZAR DMFC41K MN Prostaglandin F2-alpha receptor (PTGFR) DMFC41K MT DTT DMFC41K MA Modulator DMFC41K RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015 DMFC41K RU https://www.accessdata.fda.gov/scripts/cder/drugsatfda/ DM9HQ5U DI DM9HQ5U DM9HQ5U DN Tagraxofusp DM9HQ5U MI TTENHJ0 DM9HQ5U MN Interleukin 3 receptor alpha (IL3RA) DM9HQ5U MT DTT DM9HQ5U MA Modulator DM9HQ5U RN 2018 FDA drug approvals.Nat Rev Drug Discov. 2019 Feb;18(2):85-89. DM9HQ5U RU https://pubmed.ncbi.nlm.nih.gov/30710142 DM2M3OC DI DM2M3OC DM2M3OC DN Talazoparib DM2M3OC MI DTI7UX6 DM2M3OC MN Breast cancer resistance protein (ABCG2) DM2M3OC MT DTP DM2M3OC MA Substrate DM2M3OC RN DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. (ID: DB11760) DM2M3OC RU https://www.drugbank.ca/drugs/DB11760 DM2M3OC DI DM2M3OC DM2M3OC DN Talazoparib DM2M3OC MI DTUGYRD DM2M3OC MN P-glycoprotein 1 (ABCB1) DM2M3OC MT DTP DM2M3OC MA Substrate DM2M3OC RN DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. (ID: DB11760) DM2M3OC RU https://www.drugbank.ca/drugs/DB11760 DM1KS78 DI DM1KS78 DM1KS78 DN Talazoparib DM1KS78 MI TTEBCY8 DM1KS78 MN Poly [ADP-ribose] polymerase (PARP) DM1KS78 MT DTT DM1KS78 MA Inhibitor DM1KS78 RN 2018 FDA drug approvals.Nat Rev Drug Discov. 2019 Feb;18(2):85-89. DM1KS78 RU https://pubmed.ncbi.nlm.nih.gov/30710142 DM214Q8 DI DM214Q8 DM214Q8 DN Talbutal DM214Q8 MI TTEX6LM DM214Q8 MN GABA(A) receptor gamma-3 (GABRG3) DM214Q8 MT DTT DM214Q8 MA Modulator DM214Q8 RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. DM214Q8 RU https://www.fda.gov/ DM3PZXN DI DM3PZXN DM3PZXN DN Taliglucerase alfa DM3PZXN MI TT1B5PU DM3PZXN MN Glucosylceramidase (GBA) DM3PZXN MT DTT DM3PZXN MA Modulator DM3PZXN RN Nat Rev Drug Discov. 2013 Feb;12(2):87-90. DM3PZXN RU https://pubmed.ncbi.nlm.nih.gov/23370234 DMKBW5C DI DMKBW5C DMKBW5C DN Talimogene Laherparepvec DMKBW5C MI TTNYZG2 DMKBW5C MN Granulocyte-macrophage colony-stimulating factor (CSF2) DMKBW5C MT DTT DMKBW5C MA Modulator DMKBW5C RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. DMKBW5C RU https://www.fda.gov/ DMLB0EZ DI DMLB0EZ DMLB0EZ DN Tamoxifen DMLB0EZ MI DTI7UX6 DMLB0EZ MN Breast cancer resistance protein (ABCG2) DMLB0EZ MT DTP DMLB0EZ MA Substrate DMLB0EZ RN The phytoestrogen genistein enhances multidrug resistance in breast cancer cell lines by translational regulation of ABC transporters. Cancer Lett. 2016 Jun 28;376(1):165-72. DMLB0EZ RU http://www.ncbi.nlm.nih.gov/pubmed/27033456 DMLB0EZ DI DMLB0EZ DMLB0EZ DN Tamoxifen DMLB0EZ MI DE6OQ3W DMLB0EZ MN Cytochrome P450 1A1 (CYP1A1) DMLB0EZ MT DME DMLB0EZ MA Metabolism DMLB0EZ RN Metabolism of tamoxifen by recombinant human cytochrome P450 enzymes: formation of the 4-hydroxy, 4'-hydroxy and N-desmethyl metabolites and isomerization of trans-4-hydroxytamoxifen. Drug Metab Dispos. 2002 Aug;30(8):869-74. DMLB0EZ RU https://www.ncbi.nlm.nih.gov/pubmed/?term=12124303 DMLB0EZ DI DMLB0EZ DMLB0EZ DN Tamoxifen DMLB0EZ MI DEJGDUW DMLB0EZ MN Cytochrome P450 1A2 (CYP1A2) DMLB0EZ MT DME DMLB0EZ MA Metabolism DMLB0EZ RN Endoxifen and other metabolites of tamoxifen inhibit human hydroxysteroid sulfotransferase 2A1 (hSULT2A1). Drug Metab Dispos. 2014 Nov;42(11):1843-50. DMLB0EZ RU https://www.ncbi.nlm.nih.gov/pubmed/?term=25157097 DMLB0EZ DI DMLB0EZ DMLB0EZ DN Tamoxifen DMLB0EZ MI DEJVYAZ DMLB0EZ MN Cytochrome P450 2A6 (CYP2A6) DMLB0EZ MT DME DMLB0EZ MA Metabolism DMLB0EZ RN Genotoxicity of tamoxifen, tamoxifen epoxide and toremifene in human lymphoblastoid cells containing human cytochrome P450s. Carcinogenesis. 1994 Jan;15(1):5-9. DMLB0EZ RU https://www.ncbi.nlm.nih.gov/pubmed/?term=8293548 DMLB0EZ DI DMLB0EZ DMLB0EZ DN Tamoxifen DMLB0EZ MI DEPKLMQ DMLB0EZ MN Cytochrome P450 2B6 (CYP2B6) DMLB0EZ MT DME DMLB0EZ MA Metabolism DMLB0EZ RN Effect of tamoxifen on the enzymatic activity of human cytochrome CYP2B6. J Pharmacol Exp Ther. 2002 Jun;301(3):945-52. DMLB0EZ RU https://www.ncbi.nlm.nih.gov/pubmed/?term=12023523 DMLB0EZ DI DMLB0EZ DMLB0EZ DN Tamoxifen DMLB0EZ MI DE5IED8 DMLB0EZ MN Cytochrome P450 2C9 (CYP2C9) DMLB0EZ MT DME DMLB0EZ MA Metabolism DMLB0EZ RN Tamoxifen inhibits cytochrome P450 2C9 activity in breast cancer patients. 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DMLB0EZ RU https://www.ncbi.nlm.nih.gov/pubmed/?term=8293548 DMLB0EZ DI DMLB0EZ DMLB0EZ DN Tamoxifen DMLB0EZ MI DE4LYSA DMLB0EZ MN Cytochrome P450 3A4 (CYP3A4) DMLB0EZ MT DME DMLB0EZ MA Metabolism DMLB0EZ RN Comprehensive evaluation of tamoxifen sequential biotransformation by the human cytochrome P450 system in vitro: prominent roles for CYP3A and CYP2D6. J Pharmacol Exp Ther. 2004 Sep;310(3):1062-75. DMLB0EZ RU https://www.ncbi.nlm.nih.gov/pubmed/?term=15159443 DMLB0EZ DI DMLB0EZ DMLB0EZ DN Tamoxifen DMLB0EZ MI DEIBDNY DMLB0EZ MN Cytochrome P450 3A5 (CYP3A5) DMLB0EZ MT DME DMLB0EZ MA Metabolism DMLB0EZ RN Polymorphisms in cytochrome P4503A5 (CYP3A5) may be associated with race and tumor characteristics, but not metabolism and side effects of tamoxifen in breast cancer patients. Cancer Lett. 2005 Jan 10;217(1):61-72. DMLB0EZ RU https://www.ncbi.nlm.nih.gov/pubmed/?term=15596297 DMLB0EZ DI DMLB0EZ DMLB0EZ DN Tamoxifen DMLB0EZ MI DERD86B DMLB0EZ MN Cytochrome P450 3A7 (CYP3A7) DMLB0EZ MT DME DMLB0EZ MA Metabolism DMLB0EZ RN Drug Interactions Flockhart Table DMLB0EZ RU https://drug-interactions.medicine.iu.edu/Main-Table.aspx DMLB0EZ DI DMLB0EZ DMLB0EZ DN Tamoxifen DMLB0EZ MI TTZAYWL DMLB0EZ MN Estrogen receptor (ESR) DMLB0EZ MT DTT DMLB0EZ MA Antagonist DMLB0EZ RN Modulators of vascular sex hormone receptors and their effects in estrogen-deficiency states associated with menopause. Recent Pat Cardiovasc Drug Discov. 2008 Nov;3(3):165-86. DMLB0EZ RU https://pubmed.ncbi.nlm.nih.gov/18991792 DMLB0EZ DI DMLB0EZ DMLB0EZ DN Tamoxifen DMLB0EZ MI DEGTFWK DMLB0EZ MN Mephenytoin 4-hydroxylase (CYP2C19) DMLB0EZ MT DME DMLB0EZ MA Metabolism DMLB0EZ RN Cytochrome P450 pharmacogenetics and cancer. Oncogene. 2006 Mar 13;25(11):1679-91. DMLB0EZ RU https://www.ncbi.nlm.nih.gov/pubmed/?term=16550168 DMLB0EZ DI DMLB0EZ DMLB0EZ DN Tamoxifen DMLB0EZ MI DTPS120 DMLB0EZ MN Multidrug resistance-associated protein 7 (ABCC10) DMLB0EZ MT DTP DMLB0EZ MA Substrate DMLB0EZ RN Modulation of the ATPase and transport activities of broad-acting multidrug resistance factor ABCC10 (MRP7). Cancer Res. 2012 Dec 15;72(24):6457-67. DMLB0EZ RU http://www.ncbi.nlm.nih.gov/pubmed/23087055 DMLB0EZ DI DMLB0EZ DMLB0EZ DN Tamoxifen DMLB0EZ MI DTUGYRD DMLB0EZ MN P-glycoprotein 1 (ABCB1) DMLB0EZ MT DTP DMLB0EZ MA Substrate DMLB0EZ RN Mammalian drug efflux transporters of the ATP binding cassette (ABC) family in multidrug resistance: A review of the past decade. Cancer Lett. 2016 Jan 1;370(1):153-64. DMLB0EZ RU http://www.ncbi.nlm.nih.gov/pubmed/26499806 DMLB0EZ DI DMLB0EZ DMLB0EZ DN Tamoxifen DMLB0EZ MI DEYWLRK DMLB0EZ MN Sulfotransferase 1A1 (SULT1A1) DMLB0EZ MT DME DMLB0EZ MA Metabolism DMLB0EZ RN Tamoxifen-induced adduct formation and cell stress in human endometrial glands. Drug Metab Dispos. 2010 Jan;38(1):200-7. DMLB0EZ RU https://www.ncbi.nlm.nih.gov/pubmed/?term=19812351 DMLB0EZ DI DMLB0EZ DMLB0EZ DN Tamoxifen DMLB0EZ MI DEFQ8VO DMLB0EZ MN Thiopurine methyltransferase (TPMT) DMLB0EZ MT DME DMLB0EZ MA Metabolism DMLB0EZ RN Polymorphism of estrogen metabolism genes and cataract. Med Hypotheses. 2004;63(3):494-7. DMLB0EZ RU https://www.ncbi.nlm.nih.gov/pubmed/?term=15288375 DMLB0EZ DI DMLB0EZ DMLB0EZ DN Tamoxifen DMLB0EZ MI DEYGVN4 DMLB0EZ MN UDP-glucuronosyltransferase 1A1 (UGT1A1) DMLB0EZ MT DME DMLB0EZ MA Metabolism DMLB0EZ RN Functional significance of UDP-glucuronosyltransferase variants in the metabolism of active tamoxifen metabolites. Cancer Res. 2009 Mar 1;69(5):1892-900. DMLB0EZ RU https://www.ncbi.nlm.nih.gov/pubmed/?term=19244109 DMLB0EZ DI DMLB0EZ DMLB0EZ DN Tamoxifen DMLB0EZ MI DEL5N6Y DMLB0EZ MN UDP-glucuronosyltransferase 1A10 (UGT1A10) DMLB0EZ MT DME DMLB0EZ MA Metabolism DMLB0EZ RN Glucuronidation of active tamoxifen metabolites by the human UDP glucuronosyltransferases. Drug Metab Dispos. 2007 Nov;35(11):2006-14. DMLB0EZ RU https://www.ncbi.nlm.nih.gov/pubmed/?term=17664247 DMLB0EZ DI DMLB0EZ DMLB0EZ DN Tamoxifen DMLB0EZ MI DEB3CV1 DMLB0EZ MN UDP-glucuronosyltransferase 2B7 (UGT2B7) DMLB0EZ MT DME DMLB0EZ MA Metabolism DMLB0EZ RN Metabolism and transport of tamoxifen in relation to its effectiveness: new perspectives on an ongoing controversy. Future Oncol. 2014 Jan;10(1):107-22. DMLB0EZ RU https://www.ncbi.nlm.nih.gov/pubmed/?term=24328412 DM5QF9V DI DM5QF9V DM5QF9V DN Tamsulosin DM5QF9V MI TTNGILX DM5QF9V MN Adrenergic receptor alpha-1A (ADRA1A) DM5QF9V MT DTT DM5QF9V MA Modulator DM5QF9V RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. DM5QF9V RU https://www.fda.gov/ DM5QF9V DI DM5QF9V DM5QF9V DN Tamsulosin DM5QF9V MI DECB0K3 DM5QF9V MN Cytochrome P450 2D6 (CYP2D6) DM5QF9V MT DME DM5QF9V MA Metabolism DM5QF9V RN Identification of cytochrome P450 isozymes involved in metabolism of the alpha1-adrenoceptor blocker tamsulosin in human liver microsomes. Xenobiotica. 1998 Oct;28(10):909-22. DM5QF9V RU https://www.ncbi.nlm.nih.gov/pubmed/?term=9849639 DM5QF9V DI DM5QF9V DM5QF9V DN Tamsulosin DM5QF9V MI DE4LYSA DM5QF9V MN Cytochrome P450 3A4 (CYP3A4) DM5QF9V MT DME DM5QF9V MA Metabolism DM5QF9V RN Identification of cytochrome P450 isozymes involved in metabolism of the alpha1-adrenoceptor blocker tamsulosin in human liver microsomes. Xenobiotica. 1998 Oct;28(10):909-22. DM5QF9V RU https://www.ncbi.nlm.nih.gov/pubmed/?term=9849639 DMPHWU6 DI DMPHWU6 DMPHWU6 DN Tandospirone DMPHWU6 MI TT85JO3 DMPHWU6 MN 5-HT receptor (5HTR) DMPHWU6 MT DTT DMPHWU6 MA Modulator DMPHWU6 RN Natural products as sources of new drugs over the last 25 years. J Nat Prod. 2007 Mar;70(3):461-77. DMPHWU6 RU https://pubmed.ncbi.nlm.nih.gov/17309302 DMXLSH3 DI DMXLSH3 DMXLSH3 DN Tapentadol hydrochloride DMXLSH3 MI DE5IED8 DMXLSH3 MN Cytochrome P450 2C9 (CYP2C9) DMXLSH3 MT DME DMXLSH3 MA Metabolism DMXLSH3 RN Investigations into the drug-drug interaction potential of tapentadol in human liver microsomes and fresh human hepatocytes. Drug Metab Lett. 2008 Jan;2(1):67-75. DMXLSH3 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=19356073 DMXLSH3 DI DMXLSH3 DMXLSH3 DN Tapentadol hydrochloride DMXLSH3 MI DECB0K3 DMXLSH3 MN Cytochrome P450 2D6 (CYP2D6) DMXLSH3 MT DME DMXLSH3 MA Metabolism DMXLSH3 RN Investigations into the drug-drug interaction potential of tapentadol in human liver microsomes and fresh human hepatocytes. Drug Metab Lett. 2008 Jan;2(1):67-75. DMXLSH3 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=19356073 DMXLSH3 DI DMXLSH3 DMXLSH3 DN Tapentadol hydrochloride DMXLSH3 MI TTAWNKZ DMXLSH3 MN Norepinephrine transporter (NET) DMXLSH3 MT DTT DMXLSH3 MA Modulator DMXLSH3 RN 2008 FDA drug approvals. Nat Rev Drug Discov. 2009 Feb;8(2):93-6. DMXLSH3 RU https://pubmed.ncbi.nlm.nih.gov/19180096 DMXLSH3 DI DMXLSH3 DMXLSH3 DN Tapentadol hydrochloride DMXLSH3 MI TTKWM86 DMXLSH3 MN Opioid receptor mu (MOP) DMXLSH3 MT DTT DMXLSH3 MA Modulator DMXLSH3 RN 2008 FDA drug approvals. Nat Rev Drug Discov. 2009 Feb;8(2):93-6. DMXLSH3 RU https://pubmed.ncbi.nlm.nih.gov/19180096 DMXLSH3 DI DMXLSH3 DMXLSH3 DN Tapentadol hydrochloride DMXLSH3 MI DE85D2P DMXLSH3 MN UDP-glucuronosyltransferase 1A9 (UGT1A9) DMXLSH3 MT DME DMXLSH3 MA Metabolism DMXLSH3 RN Investigations into the drug-drug interaction potential of tapentadol in human liver microsomes and fresh human hepatocytes. Drug Metab Lett. 2008 Jan;2(1):67-75. DMXLSH3 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=19356073 DMXLSH3 DI DMXLSH3 DMXLSH3 DN Tapentadol hydrochloride DMXLSH3 MI DEB3CV1 DMXLSH3 MN UDP-glucuronosyltransferase 2B7 (UGT2B7) DMXLSH3 MT DME DMXLSH3 MA Metabolism DMXLSH3 RN Investigations into the drug-drug interaction potential of tapentadol in human liver microsomes and fresh human hepatocytes. Drug Metab Lett. 2008 Jan;2(1):67-75. DMXLSH3 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=19356073 DMLOQ1V DI DMLOQ1V DMLOQ1V DN Tasimelteon DMLOQ1V MI DEJGDUW DMLOQ1V MN Cytochrome P450 1A2 (CYP1A2) DMLOQ1V MT DME DMLOQ1V MA Metabolism DMLOQ1V RN Clinical assessment of drug-drug interactions of tasimelteon, a novel dual melatonin receptor agonist. J Clin Pharmacol. 2015 Sep;55(9):1004-11. DMLOQ1V RU https://www.ncbi.nlm.nih.gov/pubmed/?term=25851638 DMLOQ1V DI DMLOQ1V DMLOQ1V DN Tasimelteon DMLOQ1V MI DE4LYSA DMLOQ1V MN Cytochrome P450 3A4 (CYP3A4) DMLOQ1V MT DME DMLOQ1V MA Metabolism DMLOQ1V RN Clinical assessment of drug-drug interactions of tasimelteon, a novel dual melatonin receptor agonist. J Clin Pharmacol. 2015 Sep;55(9):1004-11. DMLOQ1V RU https://www.ncbi.nlm.nih.gov/pubmed/?term=25851638 DMLOQ1V DI DMLOQ1V DMLOQ1V DN Tasimelteon DMLOQ1V MI TT0WAIE DMLOQ1V MN Melatonin receptor type 1A (MTNR1A) DMLOQ1V MT DTT DMLOQ1V MA Agonist DMLOQ1V RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7393). DMLOQ1V RU http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=7393 DMLOQ1V DI DMLOQ1V DMLOQ1V DN Tasimelteon DMLOQ1V MI TT32JK8 DMLOQ1V MN Melatonin receptor type 1B (MTNR1B) DMLOQ1V MT DTT DMLOQ1V MA Agonist DMLOQ1V RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7393). DMLOQ1V RU http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=7393 DMM13DI DI DMM13DI DMM13DI DN Tasosartan DMM13DI MI TT8DBY3 DMM13DI MN Angiotensin II receptor type-1 (AGTR1) DMM13DI MT DTT DMM13DI MA Antagonist DMM13DI RN Tasosartan, enoltasosartan, and angiotensin II receptor blockade: the confounding role of protein binding. J Pharmacol Exp Ther. 2000 Nov;295(2):649-54. DMM13DI RU https://pubmed.ncbi.nlm.nih.gov/11046101 DMM13DI DI DMM13DI DMM13DI DN Tasosartan DMM13DI MI DE4LYSA DMM13DI MN Cytochrome P450 3A4 (CYP3A4) DMM13DI MT DME DMM13DI MA Metabolism DMM13DI RN Summary of information on human CYP enzymes: human P450 metabolism data. Drug Metab Rev. 2002 Feb-May;34(1-2):83-448. DMM13DI RU https://www.ncbi.nlm.nih.gov/pubmed/?term=11996015 DM3ED1A DI DM3ED1A DM3ED1A DN Tavaborole DM3ED1A MI TT37GL6 DM3ED1A MN Staphylococcus Leucyl-tRNA synthetase (Stap-coc leuS) DM3ED1A MT DTT DM3ED1A MA Inhibitor DM3ED1A RN An antifungal agent inhibits an aminoacyl-tRNA synthetase by trapping tRNA in the editing site. Science. 2007 Jun 22;316(5832):1759-61. DM3ED1A RU https://pubmed.ncbi.nlm.nih.gov/17588934 DMUOT9V DI DMUOT9V DMUOT9V DN Taxol DMUOT9V MI TTJGNVC DMUOT9V MN Apoptosis regulator Bcl-2 (BCL-2) DMUOT9V MT DTT DMUOT9V MA Modulator DMUOT9V RN Paclitaxel directly binds to Bcl-2 and functionally mimics activity of Nur77. Cancer Res. 2009 Sep 1;69(17):6906-14. DMUOT9V RU https://pubmed.ncbi.nlm.nih.gov/19671798 DMUOT9V DI DMUOT9V DMUOT9V DN Taxol DMUOT9V MI TTYFKSZ DMUOT9V MN Tubulin beta (TUBB) DMUOT9V MT DTT DMUOT9V MA Modulator DMUOT9V RN Paclitaxel directly binds to Bcl-2 and functionally mimics activity of Nur77. Cancer Res. 2009 Sep 1;69(17):6906-14. DMUOT9V RU https://pubmed.ncbi.nlm.nih.gov/19671798 DM8SMD1 DI DM8SMD1 DM8SMD1 DN Tazarotene DM8SMD1 MI DES5XRU DM8SMD1 MN Cytochrome P450 2C8 (CYP2C8) DM8SMD1 MT DME DM8SMD1 MA Metabolism DM8SMD1 RN Cytochrome P450 2C8 and flavin-containing monooxygenases are involved in the metabolism of tazarotenic acid in humans. Drug Metab Dispos. 2003 Apr;31(4):476-81. DM8SMD1 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=12642475 DM8SMD1 DI DM8SMD1 DM8SMD1 DN Tazarotene DM8SMD1 MI TT1Q3IE DM8SMD1 MN Retinoic acid receptor gamma (RARG) DM8SMD1 MT DTT DM8SMD1 MA Binder DM8SMD1 RN Recent developments in receptor-selective retinoids. Curr Pharm Des. 2000 Jun;6(9):919-31. DM8SMD1 RU https://pubmed.ncbi.nlm.nih.gov/10828316 DMWP1BH DI DMWP1BH DMWP1BH DN Tazemetostat DMWP1BH MI TT9MZCQ DMWP1BH MN Enhancer of zeste homolog 2 (EZH2) DMWP1BH MT DTT DMWP1BH MA Inhibitor DMWP1BH RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health Human Services. 2020 DMWP1BH RU https://www.accessdata.fda.gov/drugsatfda_docs/label/2020/213400s000lbl.pdf DM3XNUI DI DM3XNUI DM3XNUI DN Tazobactam DM3XNUI MI DEEZ5CV DM3XNUI MN Beta-lactamase (blaB) DM3XNUI MT DME DM3XNUI MA Metabolism DM3XNUI RN Characterization of piperacillin/tazobactam-resistant klebsiella oxytoca recovered from a nosocomial outbreak. PLoS One. 2015 Nov 5;10(11):e0142366. DM3XNUI RU https://pubmed.ncbi.nlm.nih.gov/26539828 DM3XNUI DI DM3XNUI DM3XNUI DN Tazobactam DM3XNUI MI DEYIEO5 DM3XNUI MN Beta-lactamase (blaB) DM3XNUI MT DME DM3XNUI MA Metabolism DM3XNUI RN Determination of the antibiotic resistance rates of Serratia marcescens isolates obtained from various clinical specimens. Niger J Clin Pract. 2019 Jan;22(1):125-130. DM3XNUI RU https://pubmed.ncbi.nlm.nih.gov/30666031 DM3XNUI DI DM3XNUI DM3XNUI DN Tazobactam DM3XNUI MI TTHI19T DM3XNUI MN Staphylococcus Beta-lactamase (Stap-coc blaZ) DM3XNUI MT DTT DM3XNUI MA Inhibitor DM3XNUI RN Selection of TNF-alpha binding affibody molecules using a beta-lactamase protein fragment complementation assay. N Biotechnol. 2009 Nov 30;26(5):251-9. DM3XNUI RU https://pubmed.ncbi.nlm.nih.gov/19576305 DML6OE7 DI DML6OE7 DML6OE7 DN Tbo-Filgrastim DML6OE7 MI TTC70AJ DML6OE7 MN Granulocyte colony-stimulating factor receptor (G-CSF-R) DML6OE7 MT DTT DML6OE7 MA Modulator DML6OE7 RN Nat Rev Drug Discov. 2013 Feb;12(2):87-90. DML6OE7 RU https://pubmed.ncbi.nlm.nih.gov/23370234 DMQ5S6C DI DMQ5S6C DMQ5S6C DN Tebipenem pivoxil DMQ5S6C MI TTJP4SM DMQ5S6C MN Bacterial Penicillin binding protein (Bact PBP) DMQ5S6C MT DTT DMQ5S6C MA Binder DMQ5S6C RN In Vitro Activity of Tebipenem (SPR859) against Penicillin-Binding Proteins of Gram-Negative and Gram-Positive Bacteria. Antimicrob Agents Chemother. 2019 Mar 27;63(4):e02181-18. DMQ5S6C RU https://pubmed.ncbi.nlm.nih.gov/30718255 DMYQCWT DI DMYQCWT DMYQCWT DN Tecartus DMYQCWT MI TTW640A DMYQCWT MN B-lymphocyte surface antigen B4 (CD19) DMYQCWT MT DTT DMYQCWT RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health Human Services. DMYQCWT RU https://www.fda.gov/vaccines-blood-biologics/cellular-gene-therapy-products/tecartus-brexucabtagene-autoleucel DM2OVDT DI DM2OVDT DM2OVDT DN Tecfidera DM2OVDT MI TTK3Q4W DM2OVDT MN NFE2-related factor 2 pathway (Nrf2 pathway) DM2OVDT MT DTT DM2OVDT MA Inhibitor DM2OVDT RN Radium 223 dichloride for prostate cancer treatment. Drug Des Devel Ther. 2017 Sep 6;11:2643-2651. DM2OVDT RU https://pubmed.ncbi.nlm.nih.gov/28919714 DMUEWM3 DI DMUEWM3 DMUEWM3 DN Technetium (99MTC) mebrofenin DMUEWM3 MI DTFI42L DMUEWM3 MN Multidrug resistance-associated protein 2 (ABCC2) DMUEWM3 MT DTP DMUEWM3 MA Substrate DMUEWM3 RN Mammalian drug efflux transporters of the ATP binding cassette (ABC) family in multidrug resistance: A review of the past decade. Cancer Lett. 2016 Jan 1;370(1):153-64. DMUEWM3 RU http://www.ncbi.nlm.nih.gov/pubmed/26499806 DMUEWM3 DI DMUEWM3 DMUEWM3 DN Technetium (99MTC) mebrofenin DMUEWM3 MI DTQ3ZHF DMUEWM3 MN Multidrug resistance-associated protein 3 (ABCC3) DMUEWM3 MT DTP DMUEWM3 MA Substrate DMUEWM3 RN Mammalian drug efflux transporters of the ATP binding cassette (ABC) family in multidrug resistance: A review of the past decade. Cancer Lett. 2016 Jan 1;370(1):153-64. DMUEWM3 RU http://www.ncbi.nlm.nih.gov/pubmed/26499806 DMUEWM3 DI DMUEWM3 DMUEWM3 DN Technetium (99MTC) mebrofenin DMUEWM3 MI DT3D8F0 DMUEWM3 MN Organic anion transporting polypeptide 1B1 (SLCO1B1) DMUEWM3 MT DTP DMUEWM3 MA Substrate DMUEWM3 RN Disease-Associated Changes in Drug Transporters May Impact the Pharmacokinetics and/or Toxicity of Drugs: A White Paper From the International Transporter Consortium. Clin Pharmacol Ther. 2018 Nov;104(5):900-915. DMUEWM3 RU http://www.ncbi.nlm.nih.gov/pubmed/29756222 DMUEWM3 DI DMUEWM3 DMUEWM3 DN Technetium (99MTC) mebrofenin DMUEWM3 MI DT9C1TS DMUEWM3 MN Organic anion transporting polypeptide 1B3 (SLCO1B3) DMUEWM3 MT DTP DMUEWM3 MA Substrate DMUEWM3 RN Transporters involved in the hepatic uptake of (99m)Tc-mebrofenin and indocyanine green. J Hepatol. 2011 Apr;54(4):738-45. DMUEWM3 RU http://www.ncbi.nlm.nih.gov/pubmed/21163547 DMW5ML9 DI DMW5ML9 DMW5ML9 DN Tecovirimat DMW5ML9 MI TTG7UOF DMW5ML9 MN Variola virus Envelope phospholipase F13 (VARV p37) DMW5ML9 MT DTT DMW5ML9 MA Inhibitor DMW5ML9 RN Tecovirimat, a p37 envelope protein inhibitor for the treatment of smallpox infection.IDrugs. 2010 Mar;13(3):181-91. Review DMW5ML9 RU https://pubmed.ncbi.nlm.nih.gov/20191435 DMG2SKR DI DMG2SKR DMG2SKR DN Tedizolid DMG2SKR MI TTUWYEA DMG2SKR MN Bacterial 50S ribosomal RNA (Bact 50S rRNA) DMG2SKR MT DTT DMG2SKR MA Modulator DMG2SKR RN 2014 FDA drug approvals. Nat Rev Drug Discov. 2015 Feb;14(2):77-81. DMG2SKR RU https://pubmed.ncbi.nlm.nih.gov/25633781 DMYOAKS DI DMYOAKS DMYOAKS DN Teduglutide DMYOAKS MI TT1YWO5 DMYOAKS MN Glucagon-like peptide 2 receptor (GLP2R) DMYOAKS MT DTT DMYOAKS MA Modulator DMYOAKS RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015 DMYOAKS RU https://www.accessdata.fda.gov/scripts/cder/drugsatfda/ DM31ZQM DI DM31ZQM DM31ZQM DN Tegafur DM31ZQM MI DEJGDUW DM31ZQM MN Cytochrome P450 1A2 (CYP1A2) DM31ZQM MT DME DM31ZQM MA Metabolism DM31ZQM RN Summary of information on human CYP enzymes: human P450 metabolism data. Drug Metab Rev. 2002 Feb-May;34(1-2):83-448. DM31ZQM RU https://www.ncbi.nlm.nih.gov/pubmed/?term=11996015 DM31ZQM DI DM31ZQM DM31ZQM DN Tegafur DM31ZQM MI DEJVYAZ DM31ZQM MN Cytochrome P450 2A6 (CYP2A6) DM31ZQM MT DME DM31ZQM MA Metabolism DM31ZQM RN Rapid development of S-1 in the west for therapy of advanced gastric carcinoma. Gan To Kagaku Ryoho. 2006 Jun;33 Suppl 1:117-20. DM31ZQM RU https://www.ncbi.nlm.nih.gov/pubmed/?term=16897985 DM31ZQM DI DM31ZQM DM31ZQM DN Tegafur DM31ZQM MI DES5XRU DM31ZQM MN Cytochrome P450 2C8 (CYP2C8) DM31ZQM MT DME DM31ZQM MA Metabolism DM31ZQM RN Roles of cytochromes P450 1A2, 2A6, and 2C8 in 5-fluorouracil formation from tegafur, an anticancer prodrug, in human liver microsomes. Drug Metab Dispos. 2000 Dec;28(12):1457-63. DM31ZQM RU https://www.ncbi.nlm.nih.gov/pubmed/?term=11095583 DM31ZQM DI DM31ZQM DM31ZQM DN Tegafur DM31ZQM MI DEVDYN7 DM31ZQM MN Cytochrome P450 2E1 (CYP2E1) DM31ZQM MT DME DM31ZQM MA Metabolism DM31ZQM RN Roles of cytochromes P450 1A2, 2A6, and 2C8 in 5-fluorouracil formation from tegafur, an anticancer prodrug, in human liver microsomes. Drug Metab Dispos. 2000 Dec;28(12):1457-63. DM31ZQM RU https://www.ncbi.nlm.nih.gov/pubmed/?term=11095583 DM31ZQM DI DM31ZQM DM31ZQM DN Tegafur DM31ZQM MI DEIBDNY DM31ZQM MN Cytochrome P450 3A5 (CYP3A5) DM31ZQM MT DME DM31ZQM MA Metabolism DM31ZQM RN Roles of cytochromes P450 1A2, 2A6, and 2C8 in 5-fluorouracil formation from tegafur, an anticancer prodrug, in human liver microsomes. Drug Metab Dispos. 2000 Dec;28(12):1457-63. DM31ZQM RU https://www.ncbi.nlm.nih.gov/pubmed/?term=11095583 DM3XYD1 DI DM3XYD1 DM3XYD1 DN Tegaserod DM3XYD1 MI TT07C3Y DM3XYD1 MN 5-HT 4 receptor (HTR4) DM3XYD1 MT DTT DM3XYD1 MA Agonist DM3XYD1 RN Emerging drugs for irritable bowel syndrome. Expert Opin Emerg Drugs. 2006 May;11(2):293-313. DM3XYD1 RU https://pubmed.ncbi.nlm.nih.gov/16634703 DM3XYD1 DI DM3XYD1 DM3XYD1 DN Tegaserod DM3XYD1 MI DECB0K3 DM3XYD1 MN Cytochrome P450 2D6 (CYP2D6) DM3XYD1 MT DME DM3XYD1 MA Metabolism DM3XYD1 RN In vitro metabolism of tegaserod in human liver and intestine: assessment of drug interactions. Drug Metab Dispos. 2001 Oct;29(10):1269-76. DM3XYD1 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=11560869 DMAQ2LK DI DMAQ2LK DMAQ2LK DN Teicoplanin DMAQ2LK MI TTXT4D5 DMAQ2LK MN Bacterial Cell membrane (Bact CM) DMAQ2LK MT DTT DMAQ2LK MA Inhibitor DMAQ2LK RN 2014 FDA drug approvals. Nat Rev Drug Discov. 2015 Feb;14(2):77-81. DMAQ2LK RU https://pubmed.ncbi.nlm.nih.gov/25633781 DMAQ2LK DI DMAQ2LK DMAQ2LK DN Teicoplanin DMAQ2LK MI DEYWLRK DMAQ2LK MN Sulfotransferase 1A1 (SULT1A1) DMAQ2LK MT DME DMAQ2LK MA Metabolism DMAQ2LK RN The 2.7 A resolution structure of the glycopeptide sulfotransferase Teg14. Acta Crystallogr D Biol Crystallogr. 2010 Dec;66(Pt 12):1278-86. DMAQ2LK RU https://www.ncbi.nlm.nih.gov/pubmed/?term=21123867 DMAQ2LK DI DMAQ2LK DMAQ2LK DN Teicoplanin DMAQ2LK MI DEOFMQ7 DMAQ2LK MN VanA ligase (vanA) DMAQ2LK MT DME DMAQ2LK MA Metabolism DMAQ2LK RN Genetics and mechanisms of glycopeptide resistance in enterococci. Antimicrob Agents Chemother. 1993 Aug;37(8):1563-71. DMAQ2LK RU https://pubmed.ncbi.nlm.nih.gov/8215264 DMAQ2LK DI DMAQ2LK DMAQ2LK DN Teicoplanin DMAQ2LK MI DEO97D6 DMAQ2LK MN VanA ligase (vanA) DMAQ2LK MT DME DMAQ2LK MA Metabolism DMAQ2LK RN Genetics and mechanisms of glycopeptide resistance in enterococci. Antimicrob Agents Chemother. 1993 Aug;37(8):1563-71. DMAQ2LK RU https://pubmed.ncbi.nlm.nih.gov/8215264 DMAQ2LK DI DMAQ2LK DMAQ2LK DN Teicoplanin DMAQ2LK MI DEO8E75 DMAQ2LK MN VanA ligase (vanA) DMAQ2LK MT DME DMAQ2LK MA Metabolism DMAQ2LK RN Genetics and mechanisms of glycopeptide resistance in enterococci. Antimicrob Agents Chemother. 1993 Aug;37(8):1563-71. DMAQ2LK RU https://pubmed.ncbi.nlm.nih.gov/8215264 DMAQ2LK DI DMAQ2LK DMAQ2LK DN Teicoplanin DMAQ2LK MI DEN6VO0 DMAQ2LK MN VanA ligase (vanA) DMAQ2LK MT DME DMAQ2LK MA Metabolism DMAQ2LK RN Emergence of high-level resistance to glycopeptides in Enterococcus gallinarum and Enterococcus casseliflavus. Antimicrob Agents Chemother. 1994 Jul;38(7):1675-7. DMAQ2LK RU https://pubmed.ncbi.nlm.nih.gov/7979308 DMAQ2LK DI DMAQ2LK DMAQ2LK DN Teicoplanin DMAQ2LK MI DESOXHP DMAQ2LK MN VanA ligase (vanA) DMAQ2LK MT DME DMAQ2LK MA Metabolism DMAQ2LK RN vanA in Enterococcus faecium, Enterococcus faecalis, and Enterococcus casseliflavus detected in French cattle. Foodborne Pathog Dis. 2009 Nov;6(9):1107-11. DMAQ2LK RU https://pubmed.ncbi.nlm.nih.gov/19694552 DMMRV29 DI DMMRV29 DMMRV29 DN Telaprevir DMMRV29 MI DE4LYSA DMMRV29 MN Cytochrome P450 3A4 (CYP3A4) DMMRV29 MT DME DMMRV29 MA Metabolism DMMRV29 RN Managing drug-drug interactions with boceprevir and telaprevir. Clin Liver Dis (Hoboken). 2012 Apr 26;1(2):36-40. DMMRV29 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=31186844 DMMRV29 DI DMMRV29 DMMRV29 DN Telaprevir DMMRV29 MI TTHC7JD DMMRV29 MN Hepatitis C virus Serine protease NS3/4A (HCV NS3/4A) DMMRV29 MT DTT DMMRV29 MA Modulator DMMRV29 RN 2011 FDA drug approvals. Nat Rev Drug Discov. 2012 Feb 1;11(2):91-4. DMMRV29 RU https://pubmed.ncbi.nlm.nih.gov/22293555 DMMRV29 DI DMMRV29 DMMRV29 DN Telaprevir DMMRV29 MI DTUGYRD DMMRV29 MN P-glycoprotein 1 (ABCB1) DMMRV29 MT DTP DMMRV29 MA Substrate DMMRV29 RN Drug interactions and protease inhibitors used in the treatment of hepatitis C: how to manage? Eur J Clin Pharmacol. 2014 Jul;70(7):775-89. DMMRV29 RU http://www.ncbi.nlm.nih.gov/pubmed/24817413 DM58VQX DI DM58VQX DM58VQX DN Telavancin DM58VQX MI TT7EFHR DM58VQX MN Corticotropin-releasing factor receptor 1 (CRHR1) DM58VQX MT DTT DM58VQX MA Antagonist DM58VQX RN A review of drug options in age-related macular degeneration therapy and potential new agents. Expert Opin Pharmacother. 2006 Dec;7(17):2355-68. DM58VQX RU https://pubmed.ncbi.nlm.nih.gov/17109611 DMSWUGE DI DMSWUGE DMSWUGE DN Telbivudine DMSWUGE MI TTT4SY6 DMSWUGE MN Hepatitis B virus Polymerase (HBV P) DMSWUGE MT DTT DMSWUGE MA Inhibitor DMSWUGE RN Nucleos(t)ide analogues for hepatitis B virus: strategies for long-term success. Best Pract Res Clin Gastroenterol. 2008;22(6):1081-92. DMSWUGE RU https://pubmed.ncbi.nlm.nih.gov/19187868 DMZ4P3A DI DMZ4P3A DMZ4P3A DN Telithromycin DMZ4P3A MI TTUWYEA DMZ4P3A MN Bacterial 50S ribosomal RNA (Bact 50S rRNA) DMZ4P3A MT DTT DMZ4P3A MA Binder DMZ4P3A RN An examination of the differential sensitivity to ketolide antibiotics in ermB strains of Streptococcus pyogenes and Streptococcus pneumoniae. Curr Microbiol. 2004 Oct;49(4):239-47. DMZ4P3A RU https://pubmed.ncbi.nlm.nih.gov/15386111 DMZ4P3A DI DMZ4P3A DMZ4P3A DN Telithromycin DMZ4P3A MI DE4LYSA DMZ4P3A MN Cytochrome P450 3A4 (CYP3A4) DMZ4P3A MT DME DMZ4P3A MA Metabolism DMZ4P3A RN Drug interactions during therapy with three major groups of antimicrobial agents. Expert Opin Pharmacother. 2006 Apr;7(6):639-51. DMZ4P3A RU https://www.ncbi.nlm.nih.gov/pubmed/?term=16556082 DMZ4P3A DI DMZ4P3A DMZ4P3A DN Telithromycin DMZ4P3A MI DEIBDNY DMZ4P3A MN Cytochrome P450 3A5 (CYP3A5) DMZ4P3A MT DME DMZ4P3A MA Metabolism DMZ4P3A RN Verapamil toxicity resulting from a probable interaction with telithromycin. Ann Pharmacother. 2005 Feb;39(2):357-60. DMZ4P3A RU https://www.ncbi.nlm.nih.gov/pubmed/?term=15598962 DMZ4P3A DI DMZ4P3A DMZ4P3A DN Telithromycin DMZ4P3A MI DTFI42L DMZ4P3A MN Multidrug resistance-associated protein 2 (ABCC2) DMZ4P3A MT DTP DMZ4P3A MA Substrate DMZ4P3A RN Involvement of the drug transporters p glycoprotein and multidrug resistance-associated protein Mrp2 in telithromycin transport. Antimicrob Agents Chemother. 2006 Jan;50(1):80-7. DMZ4P3A RU http://www.ncbi.nlm.nih.gov/pubmed/16377671 DMZ4P3A DI DMZ4P3A DMZ4P3A DN Telithromycin DMZ4P3A MI DTUGYRD DMZ4P3A MN P-glycoprotein 1 (ABCB1) DMZ4P3A MT DTP DMZ4P3A MA Substrate DMZ4P3A RN Differences in assessment of macrolide interaction with human MDR1 (ABCB1, P-gp) using rhodamine-123 efflux, ATPase activity and cellular accumulation assays. Eur J Pharm Sci. 2010 Sep 11;41(1):86-95. DMZ4P3A RU https://doi.org/10.1016/j.ejps.2010.05.016 DMS3GX2 DI DMS3GX2 DMS3GX2 DN Telmisartan DMS3GX2 MI TT8DBY3 DMS3GX2 MN Angiotensin II receptor type-1 (AGTR1) DMS3GX2 MT DTT DMS3GX2 MA Antagonist DMS3GX2 RN Deletion of angiotensin II type I receptor reduces hepatic steatosis. J Hepatol. 2009 Jun;50(6):1226-35. DMS3GX2 RU https://pubmed.ncbi.nlm.nih.gov/19395110 DMS3GX2 DI DMS3GX2 DMS3GX2 DN Telmisartan DMS3GX2 MI DTE2B1D DMS3GX2 MN Organic anion transporting polypeptide 1A2 (SLCO1A2) DMS3GX2 MT DTP DMS3GX2 MA Substrate DMS3GX2 RN Predominant contribution of OATP1B3 to the hepatic uptake of telmisartan, an angiotensin II receptor antagonist, in humans. Drug Metab Dispos. 2006 Jul;34(7):1109-15. DMS3GX2 RU http://www.ncbi.nlm.nih.gov/pubmed/16611857 DMS3GX2 DI DMS3GX2 DMS3GX2 DN Telmisartan DMS3GX2 MI DT9C1TS DMS3GX2 MN Organic anion transporting polypeptide 1B3 (SLCO1B3) DMS3GX2 MT DTP DMS3GX2 MA Substrate DMS3GX2 RN Predominant contribution of OATP1B3 to the hepatic uptake of telmisartan, an angiotensin II receptor antagonist, in humans. Drug Metab Dispos. 2006 Jul;34(7):1109-15. DMS3GX2 RU http://www.ncbi.nlm.nih.gov/pubmed/16611857 DMS3GX2 DI DMS3GX2 DMS3GX2 DN Telmisartan DMS3GX2 MI DTPFTEQ DMS3GX2 MN Organic anion transporting polypeptide 2B1 (SLCO2B1) DMS3GX2 MT DTP DMS3GX2 MA Substrate DMS3GX2 RN Establishment of a set of double transfectants coexpressing organic anion transporting polypeptide 1B3 and hepatic efflux transporters for the characterization of the hepatobiliary transport of telmisartan acylglucuronide. Drug Metab Dispos. 2008 Apr;36(4):796-805. DMS3GX2 RU http://www.ncbi.nlm.nih.gov/pubmed/18180273 DMS3GX2 DI DMS3GX2 DMS3GX2 DN Telmisartan DMS3GX2 MI DEYGVN4 DMS3GX2 MN UDP-glucuronosyltransferase 1A1 (UGT1A1) DMS3GX2 MT DME DMS3GX2 MA Metabolism DMS3GX2 RN The impact of pharmacogenetics of metabolic enzymes and transporters on the pharmacokinetics of telmisartan in healthy volunteers. Pharmacogenet Genomics. 2011 Sep;21(9):523-30. DMS3GX2 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=21829131 DMS3GX2 DI DMS3GX2 DMS3GX2 DN Telmisartan DMS3GX2 MI DEF2WXN DMS3GX2 MN UDP-glucuronosyltransferase 1A3 (UGT1A3) DMS3GX2 MT DME DMS3GX2 MA Metabolism DMS3GX2 RN Characterization of in vitro glucuronidation clearance of a range of drugs in human kidney microsomes: comparison with liver and intestinal glucuronidation and impact of albumin. Drug Metab Dispos. 2012 Apr;40(4):825-35. DMS3GX2 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=22275465 DMDIYFZ DI DMDIYFZ DMDIYFZ DN Telotristat ethyl DMDIYFZ MI TTDJBV3 DMDIYFZ MN Tryptophan hydroxylase (TPH) DMDIYFZ MT DTT DMDIYFZ MA Modulator DMDIYFZ RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. DMDIYFZ RU https://www.fda.gov/ DM02A65 DI DM02A65 DM02A65 DN Temazepam DM02A65 MI DEPKLMQ DM02A65 MN Cytochrome P450 2B6 (CYP2B6) DM02A65 MT DME DM02A65 MA Metabolism DM02A65 RN Human liver microsomal diazepam metabolism using cDNA-expressed cytochrome P450s: role of CYP2B6, 2C19 and the 3A subfamily. Xenobiotica. 1996 Nov;26(11):1155-66. DM02A65 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=8948091 DM02A65 DI DM02A65 DM02A65 DN Temazepam DM02A65 MI DES5XRU DM02A65 MN Cytochrome P450 2C8 (CYP2C8) DM02A65 MT DME DM02A65 MA Metabolism DM02A65 RN Human liver microsomal diazepam metabolism using cDNA-expressed cytochrome P450s: role of CYP2B6, 2C19 and the 3A subfamily. Xenobiotica. 1996 Nov;26(11):1155-66. DM02A65 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=8948091 DM02A65 DI DM02A65 DM02A65 DN Temazepam DM02A65 MI DE5IED8 DM02A65 MN Cytochrome P450 2C9 (CYP2C9) DM02A65 MT DME DM02A65 MA Metabolism DM02A65 RN Role of cDNA-expressed human cytochromes P450 in the metabolism of diazepam. Biochem Pharmacol. 1998 Mar 15;55(6):889-96. DM02A65 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=9586962 DM02A65 DI DM02A65 DM02A65 DN Temazepam DM02A65 MI DE4LYSA DM02A65 MN Cytochrome P450 3A4 (CYP3A4) DM02A65 MT DME DM02A65 MA Metabolism DM02A65 RN Human liver microsomal diazepam metabolism using cDNA-expressed cytochrome P450s: role of CYP2B6, 2C19 and the 3A subfamily. Xenobiotica. 1996 Nov;26(11):1155-66. DM02A65 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=8948091 DM02A65 DI DM02A65 DM02A65 DN Temazepam DM02A65 MI DEGTFWK DM02A65 MN Mephenytoin 4-hydroxylase (CYP2C19) DM02A65 MT DME DM02A65 MA Metabolism DM02A65 RN Human liver microsomal diazepam metabolism using cDNA-expressed cytochrome P450s: role of CYP2B6, 2C19 and the 3A subfamily. Xenobiotica. 1996 Nov;26(11):1155-66. DM02A65 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=8948091 DM02A65 DI DM02A65 DM02A65 DN Temazepam DM02A65 MI TTPTXIN DM02A65 MN Translocator protein (TSPO) DM02A65 MT DTT DM02A65 MA Modulator DM02A65 RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. DM02A65 RU https://www.fda.gov/ DM1A79H DI DM1A79H DM1A79H DN Temocapril DM1A79H MI DT3D8F0 DM1A79H MN Organic anion transporting polypeptide 1B1 (SLCO1B1) DM1A79H MT DTP DM1A79H MA Substrate DM1A79H RN Organic anion transporting polypeptide 1B1: a genetically polymorphic transporter of major importance for hepatic drug uptake. Pharmacol Rev. 2011 Mar;63(1):157-81. DM1A79H RU http://www.ncbi.nlm.nih.gov/pubmed/21245207 DM1A79H DI DM1A79H DM1A79H DN Temocapril DM1A79H MI DT9G7XN DM1A79H MN Peptide transporter 1 (SLC15A1) DM1A79H MT DTP DM1A79H MA Substrate DM1A79H RN The role of transporters in drug interactions. Eur J Pharm Sci. 2006 Apr;27(5):501-17. DM1A79H RU https://doi.org/10.1016/j.ejps.2005.11.002 DM0JXFL DI DM0JXFL DM0JXFL DN Temocapril hydrochloride DM0JXFL MI TTL69WB DM0JXFL MN Angiotensin-converting enzyme (ACE) DM0JXFL MT DTT DM0JXFL MA Modulator DM0JXFL RN Natural products as sources of new drugs over the last 25 years. J Nat Prod. 2007 Mar;70(3):461-77. DM0JXFL RU https://pubmed.ncbi.nlm.nih.gov/17309302 DMNX2QI DI DMNX2QI DMNX2QI DN Temocaprilate DMNX2QI MI DTFI42L DMNX2QI MN Multidrug resistance-associated protein 2 (ABCC2) DMNX2QI MT DTP DMNX2QI MA Substrate DMNX2QI RN Mammalian drug efflux transporters of the ATP binding cassette (ABC) family in multidrug resistance: A review of the past decade. Cancer Lett. 2016 Jan 1;370(1):153-64. DMNX2QI RU http://www.ncbi.nlm.nih.gov/pubmed/26499806 DMNX2QI DI DMNX2QI DMNX2QI DN Temocaprilate DMNX2QI MI DTFI42L DMNX2QI MN Multidrug resistance-associated protein 2 (ABCC2) DMNX2QI MT DTP DMNX2QI MA Substrate DMNX2QI RN Pharmacogenetics of membrane transporters: an update on current approaches. Mol Biotechnol. 2010 Feb;44(2):152-67. DMNX2QI RU https://doi.org/10.1007/s12033-009-9220-6 DMNX2QI DI DMNX2QI DMNX2QI DN Temocaprilate DMNX2QI MI DT9G7XN DMNX2QI MN Peptide transporter 1 (SLC15A1) DMNX2QI MT DTP DMNX2QI MA Substrate DMNX2QI RN Transporter-mediated Drug Interactions. Drug Metab Pharmacokinet. 2002;17(4):253-74. DMNX2QI RU https://doi.org/10.2133/dmpk.17.253 DMKECZD DI DMKECZD DMKECZD DN Temozolomide DMKECZD MI TTUTN1I DMKECZD MN Human Deoxyribonucleic acid (hDNA) DMKECZD MT DTT DMKECZD MA Modulator DMKECZD RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. DMKECZD RU https://www.fda.gov/ DMS104F DI DMS104F DMS104F DN Temsirolimus DMS104F MI DE4LYSA DMS104F MN Cytochrome P450 3A4 (CYP3A4) DMS104F MT DME DMS104F MA Metabolism DMS104F RN Drug Interactions Flockhart Table DMS104F RU https://drug-interactions.medicine.iu.edu/Main-Table.aspx DMS104F DI DMS104F DMS104F DN Temsirolimus DMS104F MI DEIBDNY DMS104F MN Cytochrome P450 3A5 (CYP3A5) DMS104F MT DME DMS104F MA Metabolism DMS104F RN Drug Interactions Flockhart Table DMS104F RU https://drug-interactions.medicine.iu.edu/Main-Table.aspx DMS104F DI DMS104F DMS104F DN Temsirolimus DMS104F MI DERD86B DMS104F MN Cytochrome P450 3A7 (CYP3A7) DMS104F MT DME DMS104F MA Metabolism DMS104F RN Drug Interactions Flockhart Table DMS104F RU https://drug-interactions.medicine.iu.edu/Main-Table.aspx DMS104F DI DMS104F DMS104F DN Temsirolimus DMS104F MI DTUGYRD DMS104F MN P-glycoprotein 1 (ABCB1) DMS104F MT DTP DMS104F MA Substrate DMS104F RN Association of NR1I2, CYP3A5 and ABCB1 genetic polymorphisms with variability of temsirolimus pharmacokinetics and toxicity in patients with metastatic bladder cancer. Cancer Chemother Pharmacol. 2017 Sep;80(3):653-659. DMS104F RU http://www.ncbi.nlm.nih.gov/pubmed/28676933 DMS104F DI DMS104F DMS104F DN Temsirolimus DMS104F MI TTCJG29 DMS104F MN Serine/threonine-protein kinase mTOR (mTOR) DMS104F MT DTT DMS104F MA Inhibitor DMS104F RN Advances in kinase targeting: current clinical use and clinical trials. Trends Pharmacol Sci. 2014 Nov;35(11):604-20. DMS104F RU https://pubmed.ncbi.nlm.nih.gov/25312588 DMCOZJY DI DMCOZJY DMCOZJY DN Tenapanor DMCOZJY MI DE4LYSA DMCOZJY MN Cytochrome P450 3A4 (CYP3A4) DMCOZJY MT DME DMCOZJY MA Metabolism DMCOZJY RN FDA label of Tenapanor. The 2020 official website of the U.S. Food and Drug Administration. DMCOZJY RU https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/211801s000lbl.pdf DMCOZJY DI DMCOZJY DMCOZJY DN Tenapanor DMCOZJY MI DEIBDNY DMCOZJY MN Cytochrome P450 3A5 (CYP3A5) DMCOZJY MT DME DMCOZJY MA Metabolism DMCOZJY RN FDA label of Tenapanor. The 2020 official website of the U.S. Food and Drug Administration. DMCOZJY RU https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/211801s000lbl.pdf DMCOZJY DI DMCOZJY DMCOZJY DN Tenapanor DMCOZJY MI TTFZVPO DMCOZJY MN Sodium/hydrogen exchanger 3 (SLC9A3) DMCOZJY MT DTT DMCOZJY MA Modulator DMCOZJY RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health Human Services. 2019 DMCOZJY RU https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/211801s000lbl.pdf DMJYN25 DI DMJYN25 DMJYN25 DN Tenecteplase DMJYN25 MI TTP86E2 DMJYN25 MN Plasminogen (PLG) DMJYN25 MT DTT DMJYN25 MA Activator DMJYN25 RN Thrombolytic therapies: the current state of affairs. J Endovasc Ther. 2005 Apr;12(2):224-32. DMJYN25 RU https://pubmed.ncbi.nlm.nih.gov/15823070 DMLW57T DI DMLW57T DMLW57T DN Teniposide DMLW57T MI DTI7UX6 DMLW57T MN Breast cancer resistance protein (ABCG2) DMLW57T MT DTP DMLW57T MA Substrate DMLW57T RN Mammalian drug efflux transporters of the ATP binding cassette (ABC) family in multidrug resistance: A review of the past decade. Cancer Lett. 2016 Jan 1;370(1):153-64. DMLW57T RU http://www.ncbi.nlm.nih.gov/pubmed/26499806 DMLW57T DI DMLW57T DMLW57T DN Teniposide DMLW57T MI DE4LYSA DMLW57T MN Cytochrome P450 3A4 (CYP3A4) DMLW57T MT DME DMLW57T MA Metabolism DMLW57T RN Screening for inhibitory effects of antineoplastic agents on CYP3A4 in human liver microsomes. Int J Clin Pharmacol Ther. 2001 Dec;39(12):517-28. DMLW57T RU https://www.ncbi.nlm.nih.gov/pubmed/?term=11770832 DMLW57T DI DMLW57T DMLW57T DN Teniposide DMLW57T MI DEIBDNY DMLW57T MN Cytochrome P450 3A5 (CYP3A5) DMLW57T MT DME DMLW57T MA Metabolism DMLW57T RN O-demethylation of epipodophyllotoxins is catalyzed by human cytochrome P450 3A4. Mol Pharmacol. 1994 Feb;45(2):352-8. DMLW57T RU https://www.ncbi.nlm.nih.gov/pubmed/?term=8114683 DMLW57T DI DMLW57T DMLW57T DN Teniposide DMLW57T MI TT0IHXV DMLW57T MN DNA topoisomerase II (TOP2) DMLW57T MT DTT DMLW57T MA Modulator DMLW57T RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. DMLW57T RU https://www.fda.gov/ DMLW57T DI DMLW57T DMLW57T DN Teniposide DMLW57T MI DEGTFWK DMLW57T MN Mephenytoin 4-hydroxylase (CYP2C19) DMLW57T MT DME DMLW57T MA Metabolism DMLW57T RN Drug Interactions Flockhart Table DMLW57T RU https://drug-interactions.medicine.iu.edu/Main-Table.aspx DMLW57T DI DMLW57T DMLW57T DN Teniposide DMLW57T MI DTQ3ZHF DMLW57T MN Multidrug resistance-associated protein 3 (ABCC3) DMLW57T MT DTP DMLW57T MA Substrate DMLW57T RN Characterization of drug transport by the human multidrug resistance protein 3 (ABCC3). J Biol Chem. 2001 Dec 7;276(49):46400-7. DMLW57T RU http://www.ncbi.nlm.nih.gov/pubmed/11581266 DMLW57T DI DMLW57T DMLW57T DN Teniposide DMLW57T MI DTUGYRD DMLW57T MN P-glycoprotein 1 (ABCB1) DMLW57T MT DTP DMLW57T MA Substrate DMLW57T RN Mammalian drug efflux transporters of the ATP binding cassette (ABC) family in multidrug resistance: A review of the past decade. Cancer Lett. 2016 Jan 1;370(1):153-64. DMLW57T RU http://www.ncbi.nlm.nih.gov/pubmed/26499806 DM1IS6U DI DM1IS6U DM1IS6U DN Tenofovir DM1IS6U MI DTI7UX6 DM1IS6U MN Breast cancer resistance protein (ABCG2) DM1IS6U MT DTP DM1IS6U MA Substrate DM1IS6U RN KEGG: new perspectives on genomes, pathways, diseases and drugs. Nucleic Acids Res. 2017 Jan 4;45(D1):D353-D361. (dg:DG01913) DM1IS6U RU https://www.kegg.jp/dbget-bin/www_bget?dg:DG01913 DM1IS6U DI DM1IS6U DM1IS6U DN Tenofovir DM1IS6U MI TT84ETX DM1IS6U MN Human immunodeficiency virus Reverse transcriptase (HIV RT) DM1IS6U MT DTT DM1IS6U MA Inhibitor DM1IS6U RN Antiviral drugs in current clinical use. J Clin Virol. 2004 Jun;30(2):115-33. DM1IS6U RU https://pubmed.ncbi.nlm.nih.gov/15125867 DM1IS6U DI DM1IS6U DM1IS6U DN Tenofovir DM1IS6U MI DTCSGPB DM1IS6U MN Multidrug resistance-associated protein 4 (ABCC4) DM1IS6U MT DTP DM1IS6U MA Substrate DM1IS6U RN Functional involvement of multidrug resistance-associated protein 4 (MRP4/ABCC4) in the renal elimination of the antiviral drugs adefovir and tenofovir. Mol Pharmacol. 2007 Feb;71(2):619-27. DM1IS6U RU http://www.ncbi.nlm.nih.gov/pubmed/17110501 DM1IS6U DI DM1IS6U DM1IS6U DN Tenofovir DM1IS6U MI DTPS120 DM1IS6U MN Multidrug resistance-associated protein 7 (ABCC10) DM1IS6U MT DTP DM1IS6U MA Substrate DM1IS6U RN Genetic variants of ABCC10, a novel tenofovir transporter, are associated with kidney tubular dysfunction. J Infect Dis. 2011 Jul 1;204(1):145-53. DM1IS6U RU http://www.ncbi.nlm.nih.gov/pubmed/21628669 DM1IS6U DI DM1IS6U DM1IS6U DN Tenofovir DM1IS6U MI DTWN7FC DM1IS6U MN Multidrug resistance-associated protein 8 (ABCC11) DM1IS6U MT DTP DM1IS6U MA Substrate DM1IS6U RN Tenofovir Disoproxil Fumarate Is a New Substrate of ATP-Binding Cassette Subfamily C Member 11. Antimicrob Agents Chemother. 2017 Mar 24;61(4). pii: e01725-16. DM1IS6U RU http://www.ncbi.nlm.nih.gov/pubmed/28167562 DM1IS6U DI DM1IS6U DM1IS6U DN Tenofovir DM1IS6U MI DTQ23VB DM1IS6U MN Organic anion transporter 1 (SLC22A6) DM1IS6U MT DTP DM1IS6U MA Substrate DM1IS6U RN Human renal organic anion transporter 1 (hOAT1) and its role in the nephrotoxicity of antiviral nucleotide analogs. Nucleosides Nucleotides Nucleic Acids. 2001 Apr-Jul;20(4-7):641-8. DM1IS6U RU http://www.ncbi.nlm.nih.gov/pubmed/11563082 DM1IS6U DI DM1IS6U DM1IS6U DN Tenofovir DM1IS6U MI DTVP67E DM1IS6U MN Organic anion transporter 3 (SLC22A8) DM1IS6U MT DTP DM1IS6U MA Substrate DM1IS6U RN Tenofovir alafenamide is not a substrate for renal organic anion transporters (OATs) and does not exhibit OAT-dependent cytotoxicity. Antivir Ther. 2014;19(7):687-92. DM1IS6U RU http://www.ncbi.nlm.nih.gov/pubmed/24699134 DM1IS6U DI DM1IS6U DM1IS6U DN Tenofovir DM1IS6U MI DTUGYRD DM1IS6U MN P-glycoprotein 1 (ABCB1) DM1IS6U MT DTP DM1IS6U MA Substrate DM1IS6U RN KEGG: new perspectives on genomes, pathways, diseases and drugs. Nucleic Acids Res. 2017 Jan 4;45(D1):D353-D361. (dg:DG01665) DM1IS6U RU https://www.kegg.jp/dbget-bin/www_bget?dg:DG01665 DMTQF4A DI DMTQF4A DMTQF4A DN Tenofovir alafenamide DMTQF4A MI DE14JZK DMTQF4A MN Cathepsin A (CTSA) DMTQF4A MT DME DMTQF4A MA Metabolism DMTQF4A RN Bictegravir/Emtricitabine/Tenofovir Alafenamide: a review in HIV-1 infection. Drugs. 2018 Nov;78(17):1817-1828. DMTQF4A RU https://www.ncbi.nlm.nih.gov/pubmed/?term=30460547 DMTQF4A DI DMTQF4A DMTQF4A DN Tenofovir alafenamide DMTQF4A MI DE4LYSA DMTQF4A MN Cytochrome P450 3A4 (CYP3A4) DMTQF4A MT DME DMTQF4A MA Metabolism DMTQF4A RN FDA label of Bictegravir, emtricitabine, and tenofovir alafenamide. The 2020 official website of the U.S. Food and Drug Administration. DMTQF4A RU https://www.accessdata.fda.gov/drugsatfda_docs/label/2018/210251s000lbl.pdf DMSY4ZG DI DMSY4ZG DMSY4ZG DN Tenofovir disoproxil fumarate DMSY4ZG MI DE4LYSA DMSY4ZG MN Cytochrome P450 3A4 (CYP3A4) DMSY4ZG MT DME DMSY4ZG MA Metabolism DMSY4ZG RN FDA label of Bictegravir, emtricitabine, and tenofovir alafenamide. The 2020 official website of the U.S. Food and Drug Administration. DMSY4ZG RU https://www.accessdata.fda.gov/drugsatfda_docs/label/2018/210251s000lbl.pdf DMSY4ZG DI DMSY4ZG DMSY4ZG DN Tenofovir disoproxil fumarate DMSY4ZG MI TT84ETX DMSY4ZG MN Human immunodeficiency virus Reverse transcriptase (HIV RT) DMSY4ZG MT DTT DMSY4ZG MA Modulator DMSY4ZG RN Nat Rev Drug Discov. 2013 Feb;12(2):87-90. DMSY4ZG RU https://pubmed.ncbi.nlm.nih.gov/23370234 DMVAZP9 DI DMVAZP9 DMVAZP9 DN Tenoxicam DMVAZP9 MI DE5IED8 DMVAZP9 MN Cytochrome P450 2C9 (CYP2C9) DMVAZP9 MT DME DMVAZP9 MA Metabolism DMVAZP9 RN CYP2C9 genotypes and the pharmacokinetics of tenoxicam in Brazilians. Clin Pharmacol Ther. 2004 Jul;76(1):18-26. DMVAZP9 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=15229460 DMVAZP9 DI DMVAZP9 DMVAZP9 DN Tenoxicam DMVAZP9 MI DTUGYRD DMVAZP9 MN P-glycoprotein 1 (ABCB1) DMVAZP9 MT DTP DMVAZP9 MA Substrate DMVAZP9 RN Human intestinal transporter database: QSAR modeling and virtual profiling of drug uptake, efflux and interactions. Pharm Res. 2013 Apr;30(4):996-1007. DMVAZP9 RU https://doi.org/10.1007/s11095-012-0935-x DMVAZP9 DI DMVAZP9 DMVAZP9 DN Tenoxicam DMVAZP9 MI TTVKILB DMVAZP9 MN Prostaglandin G/H synthase 2 (COX-2) DMVAZP9 MT DTT DMVAZP9 MA Inhibitor DMVAZP9 RN The use and safety profile of non-steroidal antiinflammatory drugs among Turkish patients with osteoarthritis. Turk J Gastroenterol. 2005 Sep;16(3):138-42. DMVAZP9 RU https://pubmed.ncbi.nlm.nih.gov/16245223 DMUQ0E8 DI DMUQ0E8 DMUQ0E8 DN Tepotinib DMUQ0E8 MI TTNDSF4 DMUQ0E8 MN Proto-oncogene c-Met (MET) DMUQ0E8 MT DTT DMUQ0E8 MA Modulator DMUQ0E8 RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health Human Services. 2021 DMUQ0E8 RU https://www.accessdata.fda.gov/drugsatfda_docs/label/2021/214096s000lbl.pdf DM4L59B DI DM4L59B DM4L59B DN Teprotumumab DM4L59B MI TTHRID2 DM4L59B MN Insulin-like growth factor I receptor (IGF1R) DM4L59B MT DTT DM4L59B MA Antagonist DM4L59B RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health Human Services. 2020 DM4L59B RU https://www.accessdata.fda.gov/drugsatfda_docs/label/2020/761143s000lbl.pdf DM3JCVS DI DM3JCVS DM3JCVS DN Terazosin DM3JCVS MI TT34BHT DM3JCVS MN Adrenergic receptor alpha-1D (ADRA1D) DM3JCVS MT DTT DM3JCVS MA Antagonist DM3JCVS RN Induction of prostate apoptosis by alpha1-adrenoceptor antagonists: mechanistic significance of the quinazoline component. Prostate Cancer Prostatic Dis. 2002;5(2):88-95. DM3JCVS RU https://pubmed.ncbi.nlm.nih.gov/12496995 DMI6HUW DI DMI6HUW DMI6HUW DN Terbinafine DMI6HUW MI TTM9XSU DMI6HUW MN Candida Squalene epoxidase (Candi ERG1) DMI6HUW MT DTT DMI6HUW MA Modulator DMI6HUW RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. DMI6HUW RU https://www.fda.gov/ DMI6HUW DI DMI6HUW DMI6HUW DN Terbinafine DMI6HUW MI DEJGDUW DMI6HUW MN Cytochrome P450 1A2 (CYP1A2) DMI6HUW MT DME DMI6HUW MA Metabolism DMI6HUW RN Multiple cytochrome P-450s involved in the metabolism of terbinafine suggest a limited potential for drug-drug interactions. Drug Metab Dispos. 1999 Sep;27(9):1029-38. DMI6HUW RU https://www.ncbi.nlm.nih.gov/pubmed/?term=10460803 DMI6HUW DI DMI6HUW DMI6HUW DN Terbinafine DMI6HUW MI DES5XRU DMI6HUW MN Cytochrome P450 2C8 (CYP2C8) DMI6HUW MT DME DMI6HUW MA Metabolism DMI6HUW RN Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. DMI6HUW RU https://www.ncbi.nlm.nih.gov/pubmed/?term=19515014 DMI6HUW DI DMI6HUW DMI6HUW DN Terbinafine DMI6HUW MI DE5IED8 DMI6HUW MN Cytochrome P450 2C9 (CYP2C9) DMI6HUW MT DME DMI6HUW MA Metabolism DMI6HUW RN Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. DMI6HUW RU https://www.ncbi.nlm.nih.gov/pubmed/?term=19515014 DMI6HUW DI DMI6HUW DMI6HUW DN Terbinafine DMI6HUW MI DE4LYSA DMI6HUW MN Cytochrome P450 3A4 (CYP3A4) DMI6HUW MT DME DMI6HUW MA Metabolism DMI6HUW RN Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. DMI6HUW RU https://www.ncbi.nlm.nih.gov/pubmed/?term=19515014 DMI6HUW DI DMI6HUW DMI6HUW DN Terbinafine DMI6HUW MI DEGTFWK DMI6HUW MN Mephenytoin 4-hydroxylase (CYP2C19) DMI6HUW MT DME DMI6HUW MA Metabolism DMI6HUW RN Multiple cytochrome P-450s involved in the metabolism of terbinafine suggest a limited potential for drug-drug interactions. Drug Metab Dispos. 1999 Sep;27(9):1029-38. DMI6HUW RU https://www.ncbi.nlm.nih.gov/pubmed/?term=10460803 DMI6HUW DI DMI6HUW DMI6HUW DN Terbinafine DMI6HUW MI DE073H6 DMI6HUW MN Prostaglandin G/H synthase 1 (COX-1) DMI6HUW MT DME DMI6HUW MA Metabolism DMI6HUW RN Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. DMI6HUW RU https://www.ncbi.nlm.nih.gov/pubmed/?term=19515014 DMD4381 DI DMD4381 DMD4381 DN Terbutaline DMD4381 MI TT2CJVK DMD4381 MN Adrenergic receptor beta-2 (ADRB2) DMD4381 MT DTT DMD4381 MA Agonist DMD4381 RN Evaluation of a new oral beta2-adrenoceptor stimulant bronchodilator, terbutaline. Pharmacology. 1975;13(3):201-11. DMD4381 RU https://pubmed.ncbi.nlm.nih.gov/239414 DMD4381 DI DMD4381 DMD4381 DN Terbutaline DMD4381 MI DTT79CX DMD4381 MN Organic cation transporter 1 (SLC22A1) DMD4381 MT DTP DMD4381 MA Substrate DMD4381 RN Identification of novel substrates and structure-activity relationship of cellular uptake mediated by human organic cation transporters 1 and 2. J Med Chem. 2013 Sep 26;56(18):7232-42. DMD4381 RU http://www.ncbi.nlm.nih.gov/pubmed/23984907 DMVPWLZ DI DMVPWLZ DMVPWLZ DN Terbutyline DMVPWLZ MI TTVIREA DMVPWLZ MN Adrenergic receptor (ADR) DMVPWLZ MT DTT DMVPWLZ MA Modulator DMVPWLZ RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015 DMVPWLZ RU https://www.accessdata.fda.gov/scripts/cder/drugsatfda/ DMJ13KI DI DMJ13KI DMJ13KI DN Terconazole DMJ13KI MI TTTSOUD DMJ13KI MN Candida Cytochrome P450 51 (Candi ERG11) DMJ13KI MT DTT DMJ13KI MA Inhibitor DMJ13KI RN Mode of action of anti-Candida drugs: focus on terconazole and other ergosterol biosynthesis inhibitors. Am J Obstet Gynecol. 1991 Oct;165(4 Pt 2):1193-9. DMJ13KI RU https://pubmed.ncbi.nlm.nih.gov/1951574 DMQ2FKJ DI DMQ2FKJ DMQ2FKJ DN Teriflunomide DMQ2FKJ MI DTI7UX6 DMQ2FKJ MN Breast cancer resistance protein (ABCG2) DMQ2FKJ MT DTP DMQ2FKJ MA Substrate DMQ2FKJ RN MDR-ABC transporters: biomarkers in rheumatoid arthritis. Clin Exp Rheumatol. 2013 Sep-Oct;31(5):779-87. DMQ2FKJ RU http://www.ncbi.nlm.nih.gov/pubmed/23711386 DMQ2FKJ DI DMQ2FKJ DMQ2FKJ DN Teriflunomide DMQ2FKJ MI TTLVP78 DMQ2FKJ MN Dihydroorotate dehydrogenase (DHODH) DMQ2FKJ MT DTT DMQ2FKJ MA Modulator DMQ2FKJ RN Nat Rev Drug Discov. 2013 Feb;12(2):87-90. DMQ2FKJ RU https://pubmed.ncbi.nlm.nih.gov/23370234 DMQ2FKJ DI DMQ2FKJ DMQ2FKJ DN Teriflunomide DMQ2FKJ MI TTPADOQ DMQ2FKJ MN HMG-CoA reductase (HMGCR) DMQ2FKJ MT DTT DMQ2FKJ MA Inhibitor DMQ2FKJ RN Emerging drugs in peripheral arterial disease. Expert Opin Emerg Drugs. 2006 Mar;11(1):75-90. DMQ2FKJ RU https://pubmed.ncbi.nlm.nih.gov/16503827 DMQ2FKJ DI DMQ2FKJ DMQ2FKJ DN Teriflunomide DMQ2FKJ MI TT3PQ2Y DMQ2FKJ MN Plasmodium Dihydroorotate dehydrogenase (Malaria DHOdehase) DMQ2FKJ MT DTT DMQ2FKJ MA Inhibitor DMQ2FKJ RN Expression and characterization of E. coli-produced soluble, functional human dihydroorotate dehydrogenase: a potential target for immunosuppression. J Mol Microbiol Biotechnol. 1999 Aug;1(1):183-8. DMQ2FKJ RU https://pubmed.ncbi.nlm.nih.gov/10941801 DMMC45B DI DMMC45B DMMC45B DN Teriparatide DMMC45B MI TT6F7GZ DMMC45B MN Parathyroid hormone (PTH) DMMC45B MT DTT DMMC45B MA Modulator DMMC45B RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. DMMC45B RU https://www.fda.gov/ DMT9FH3 DI DMT9FH3 DMT9FH3 DN Terlipressin DMT9FH3 MI TT4TFGN DMT9FH3 MN Vasopressin V1a receptor (V1AR) DMT9FH3 MT DTT DMT9FH3 MA Stimulator DMT9FH3 RN Investigational vasopressin receptor modulators in the pipeline. Expert Opin Investig Drugs. 2009 Aug;18(8):1119-31. DMT9FH3 RU https://pubmed.ncbi.nlm.nih.gov/19589090 DM2L3D5 DI DM2L3D5 DM2L3D5 DN Tertatolol DM2L3D5 MI TTSQIFT DM2L3D5 MN 5-HT 1A receptor (HTR1A) DM2L3D5 MT DTT DM2L3D5 MA Inhibitor DM2L3D5 RN Synthesis of new derivatives of 8-OH-DPAT: Influence of substitution on the aromatic ring on the pharmacological profile, Bioorg. Med. Chem. Lett. 3(10):2035-2038 (1993). DM2L3D5 RU http://www.sciencedirect.com/science/article/pii/S0960894X0181009X DM2L3D5 DI DM2L3D5 DM2L3D5 DN Tertatolol DM2L3D5 MI DECB0K3 DM2L3D5 MN Cytochrome P450 2D6 (CYP2D6) DM2L3D5 MT DME DM2L3D5 MA Metabolism DM2L3D5 RN Application of substrate depletion assay to evaluation of CYP isoforms responsible for stereoselective metabolism of carvedilol. Drug Metab Pharmacokinet. 2016 Dec;31(6):425-432. DM2L3D5 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=27836712 DM9GP85 DI DM9GP85 DM9GP85 DN Tesamorelin DM9GP85 MI TTG4R8V DM9GP85 MN Growth hormone-releasing hormone receptor (GHRHR) DM9GP85 MT DTT DM9GP85 MA Binder DM9GP85 RN Mullard A: 2010 FDA drug approvals. Nat Rev Drug Discov. 2011 Feb;10(2):82-5. DM9GP85 RU https://pubmed.ncbi.nlm.nih.gov/21283092 DMVY4GN DI DMVY4GN DMVY4GN DN Testolactone DMVY4GN MI TTSZLWK DMVY4GN MN Aromatase (CYP19A1) DMVY4GN MT DTT DMVY4GN MA Inhibitor DMVY4GN RN Aromatase inhibitors for male infertility. J Urol. 2002 Feb;167(2 Pt 1):624-9. DMVY4GN RU https://pubmed.ncbi.nlm.nih.gov/11792932 DM7HUNW DI DM7HUNW DM7HUNW DN Testosterone DM7HUNW MI TTS64P2 DM7HUNW MN Androgen receptor (AR) DM7HUNW MT DTT DM7HUNW MA Agonist DM7HUNW RN Molecular mechanism of androgen action. Trends Endocrinol Metab. 1998 Oct 1;9(8):317-24. DM7HUNW RU https://pubmed.ncbi.nlm.nih.gov/18406296 DM7HUNW DI DM7HUNW DM7HUNW DN Testosterone DM7HUNW MI DTI7UX6 DM7HUNW MN Breast cancer resistance protein (ABCG2) DM7HUNW MT DTP DM7HUNW MA Substrate DM7HUNW RN Association of the ABCG2 C421A polymorphism with prostate cancer risk and survival. BJU Int. 2008 Dec;102(11):1694-9. DM7HUNW RU http://www.ncbi.nlm.nih.gov/pubmed/18710444 DM7HUNW DI DM7HUNW DM7HUNW DN Testosterone DM7HUNW MI DT9C1TS DM7HUNW MN Organic anion transporting polypeptide 1B3 (SLCO1B3) DM7HUNW MT DTP DM7HUNW MA Substrate DM7HUNW RN Effect of SLCO1B3 haplotype on testosterone transport and clinical outcome in caucasian patients with androgen-independent prostatic cancer. Clin Cancer Res. 2008 Jun 1;14(11):3312-8. DM7HUNW RU http://www.ncbi.nlm.nih.gov/pubmed/18519758 DM7HUNW DI DM7HUNW DM7HUNW DN Testosterone DM7HUNW MI DTUGYRD DM7HUNW MN P-glycoprotein 1 (ABCB1) DM7HUNW MT DTP DM7HUNW MA Substrate DM7HUNW RN A novel screening strategy to identify ABCB1 substrates and inhibitors. Naunyn Schmiedebergs Arch Pharmacol. 2009 Jan;379(1):11-26. DM7HUNW RU https://doi.org/10.1007/s00210-008-0345-0 DMC1TEV DI DMC1TEV DMC1TEV DN Testosterone cypionate DMC1TEV MI DEQX145 DMC1TEV MN Aromatase (CYP19A1) DMC1TEV MT DME DMC1TEV MA Metabolism DMC1TEV RN Loss of aromatase cytochrome P450 function as a risk factor for Parkinson's disease? Brain Res Rev. 2008 Mar;57(2):431-43. DMC1TEV RU https://www.ncbi.nlm.nih.gov/pubmed/?term=18063054 DMC1TEV DI DMC1TEV DMC1TEV DN Testosterone cypionate DMC1TEV MI DEKP5HX DMC1TEV MN Cholesterol 24-hydroxylase (CYP46A1) DMC1TEV MT DME DMC1TEV MA Metabolism DMC1TEV RN Broad substrate specificity of human cytochrome P450 46A1 which initiates cholesterol degradation in the brain. Biochemistry. 2003 Dec 9;42(48):14284-92. DMC1TEV RU https://www.ncbi.nlm.nih.gov/pubmed/?term=14640697 DMC1TEV DI DMC1TEV DMC1TEV DN Testosterone cypionate DMC1TEV MI DEHDW40 DMC1TEV MN Cytochrome P450 154C2 (cyp154) DMC1TEV MT DME DMC1TEV MA Metabolism DMC1TEV RN nan DMC1TEV RU nan DMC1TEV DI DMC1TEV DMC1TEV DN Testosterone cypionate DMC1TEV MI DE6OQ3W DMC1TEV MN Cytochrome P450 1A1 (CYP1A1) DMC1TEV MT DME DMC1TEV MA Metabolism DMC1TEV RN Allelic variants of human cytochrome P450 1A1 (CYP1A1): effect of T461N and I462V substitutions on steroid hydroxylase specificity. Pharmacogenetics. 2000 Aug;10(6):519-30. DMC1TEV RU https://www.ncbi.nlm.nih.gov/pubmed/?term=10975606 DMC1TEV DI DMC1TEV DMC1TEV DN Testosterone cypionate DMC1TEV MI DE9QHP6 DMC1TEV MN Cytochrome P450 1B1 (CYP1B1) DMC1TEV MT DME DMC1TEV MA Metabolism DMC1TEV RN Catalytic properties of polymorphic human cytochrome P450 1B1 variants. Carcinogenesis. 1999 Aug;20(8):1607-13. DMC1TEV RU https://www.ncbi.nlm.nih.gov/pubmed/?term=10426814 DMC1TEV DI DMC1TEV DMC1TEV DN Testosterone cypionate DMC1TEV MI DEXZA9U DMC1TEV MN Cytochrome P450 2A13 (CYP2A13) DMC1TEV MT DME DMC1TEV MA Metabolism DMC1TEV RN Effects of 8-methoxypsoralen on cytochrome P450 2A13. Carcinogenesis. 2005 Mar;26(3):621-9. DMC1TEV RU https://www.ncbi.nlm.nih.gov/pubmed/?term=15579482 DMC1TEV DI DMC1TEV DMC1TEV DN Testosterone cypionate DMC1TEV MI DEPKLMQ DMC1TEV MN Cytochrome P450 2B6 (CYP2B6) DMC1TEV MT DME DMC1TEV MA Metabolism DMC1TEV RN Insights into CYP2B6-mediated drug-drug interactions. Acta Pharm Sin B. 2016 Sep;6(5):413-425. DMC1TEV RU https://www.ncbi.nlm.nih.gov/pubmed/?term=27709010 DMC1TEV DI DMC1TEV DMC1TEV DN Testosterone cypionate DMC1TEV MI DES5XRU DMC1TEV MN Cytochrome P450 2C8 (CYP2C8) DMC1TEV MT DME DMC1TEV MA Metabolism DMC1TEV RN Role of cytochrome P450 2C8 in drug metabolism and interactions. Pharmacol Rev. 2016 Jan;68(1):168-241. DMC1TEV RU https://www.ncbi.nlm.nih.gov/pubmed/?term=26721703 DMC1TEV DI DMC1TEV DMC1TEV DN Testosterone cypionate DMC1TEV MI DE5IED8 DMC1TEV MN Cytochrome P450 2C9 (CYP2C9) DMC1TEV MT DME DMC1TEV MA Metabolism DMC1TEV RN Human cytochrome p450 induction and inhibition potential of clevidipine and its primary metabolite h152/81. Drug Metab Dispos. 2006 May;34(5):734-7. DMC1TEV RU https://www.ncbi.nlm.nih.gov/pubmed/?term=16501008 DMC1TEV DI DMC1TEV DMC1TEV DN Testosterone cypionate DMC1TEV MI DE4LYSA DMC1TEV MN Cytochrome P450 3A4 (CYP3A4) DMC1TEV MT DME DMC1TEV MA Metabolism DMC1TEV RN Digging deeper into CYP3A testosterone metabolism: kinetic, regioselectivity, and stereoselectivity differences between CYP3A4/5 and CYP3A7. Drug Metab Dispos. 2017 Dec;45(12):1266-1275. DMC1TEV RU https://www.ncbi.nlm.nih.gov/pubmed/?term=28986474 DMC1TEV DI DMC1TEV DMC1TEV DN Testosterone cypionate DMC1TEV MI DEO1IE3 DMC1TEV MN Cytochrome P450 3A43 (CYP3A43) DMC1TEV MT DME DMC1TEV MA Metabolism DMC1TEV RN cDNA cloning and initial characterization of CYP3A43, a novel human cytochrome P450. Mol Pharmacol. 2001 Feb;59(2):386-92. DMC1TEV RU https://www.ncbi.nlm.nih.gov/pubmed/?term=11160876 DMC1TEV DI DMC1TEV DMC1TEV DN Testosterone cypionate DMC1TEV MI DEIBDNY DMC1TEV MN Cytochrome P450 3A5 (CYP3A5) DMC1TEV MT DME DMC1TEV MA Metabolism DMC1TEV RN In vitro metabolism of midazolam, triazolam, nifedipine, and testosterone by human liver microsomes and recombinant cytochromes p450: role of cyp3a4 and cyp3a5. Drug Metab Dispos. 2003 Jul;31(7):938-44. DMC1TEV RU https://www.ncbi.nlm.nih.gov/pubmed/?term=12814972 DMC1TEV DI DMC1TEV DMC1TEV DN Testosterone cypionate DMC1TEV MI DERD86B DMC1TEV MN Cytochrome P450 3A7 (CYP3A7) DMC1TEV MT DME DMC1TEV MA Metabolism DMC1TEV RN Steroid hydroxylation by human fetal CYP3A7 and human NADPH-cytochrome P450 reductase coexpressed in insect cells using baculovirus. Res Commun Mol Pathol Pharmacol. 1998 Apr;100(1):15-28. DMC1TEV RU https://www.ncbi.nlm.nih.gov/pubmed/?term=9644715 DMC1TEV DI DMC1TEV DMC1TEV DN Testosterone cypionate DMC1TEV MI DEMF740 DMC1TEV MN Cytochrome P450 4B1 (CYP4B1) DMC1TEV MT DME DMC1TEV MA Metabolism DMC1TEV RN Steroid hormone hydroxylase specificities of eleven cDNA-expressed human cytochrome P450s. Arch Biochem Biophys. 1991 Oct;290(1):160-6. DMC1TEV RU https://www.ncbi.nlm.nih.gov/pubmed/?term=1898086 DMC1TEV DI DMC1TEV DMC1TEV DN Testosterone cypionate DMC1TEV MI DEZ1H4L DMC1TEV MN Cytochrome P450 MEG (cyp106) DMC1TEV MT DME DMC1TEV MA Metabolism DMC1TEV RN nan DMC1TEV RU nan DMC1TEV DI DMC1TEV DMC1TEV DN Testosterone cypionate DMC1TEV MI DEGTB1K DMC1TEV MN Dehydrogenase/reductase retSDR3 (HSD17B14) DMC1TEV MT DME DMC1TEV MA Metabolism DMC1TEV RN Expression patterns of 17beta-hydroxysteroid dehydrogenase 14 in human tissues. Horm Metab Res. 2012 Dec;44(13):949-56. DMC1TEV RU https://pubmed.ncbi.nlm.nih.gov/22864907 DMC1TEV DI DMC1TEV DMC1TEV DN Testosterone cypionate DMC1TEV MI DER0XCH DMC1TEV MN Farnesol dehydrogenase (AKR1B15) DMC1TEV MT DME DMC1TEV MA Metabolism DMC1TEV RN Aldo-keto Reductase 1B15 (AKR1B15): a mitochondrial human aldo-keto reductase with activity toward steroids and 3-keto-acyl-CoA conjugates. J Biol Chem. 2015 Mar 6;290(10):6531-45. DMC1TEV RU https://www.ncbi.nlm.nih.gov/pubmed/?term=25577493 DMC1TEV DI DMC1TEV DMC1TEV DN Testosterone cypionate DMC1TEV MI DEGTFWK DMC1TEV MN Mephenytoin 4-hydroxylase (CYP2C19) DMC1TEV MT DME DMC1TEV MA Metabolism DMC1TEV RN Progesterone and testosterone hydroxylation by cytochromes P450 2C19, 2C9, and 3A4 in human liver microsomes. Arch Biochem Biophys. 1997 Oct 1;346(1):161-9. DMC1TEV RU https://www.ncbi.nlm.nih.gov/pubmed/?term=9328296 DMC1TEV DI DMC1TEV DMC1TEV DN Testosterone cypionate DMC1TEV MI DEOG15F DMC1TEV MN Steroid 5-alpha-reductase 1 (SRD5A1) DMC1TEV MT DME DMC1TEV MA Metabolism DMC1TEV RN Molecular analysis of the SRD5A1 and SRD5A2 genes in patients with benign prostatic hyperplasia with regard to metabolic parameters and selected hormone levels. Int J Environ Res Public Health. 2017 Oct 30;14(11). DMC1TEV RU https://www.ncbi.nlm.nih.gov/pubmed/29084161 DMC1TEV DI DMC1TEV DMC1TEV DN Testosterone cypionate DMC1TEV MI DEPTJ3D DMC1TEV MN Steroid 5-alpha-reductase 2 (SRD5A2) DMC1TEV MT DME DMC1TEV MA Metabolism DMC1TEV RN Molecular analysis of the SRD5A1 and SRD5A2 genes in patients with benign prostatic hyperplasia with regard to metabolic parameters and selected hormone levels. Int J Environ Res Public Health. 2017 Oct 30;14(11). DMC1TEV RU https://www.ncbi.nlm.nih.gov/pubmed/29084161 DMC1TEV DI DMC1TEV DMC1TEV DN Testosterone cypionate DMC1TEV MI DEZGVDW DMC1TEV MN Steroid 5-alpha-reductase 3 (SRD5A3) DMC1TEV MT DME DMC1TEV MA Metabolism DMC1TEV RN Molecular analysis of the SRD5A1 and SRD5A2 genes in patients with benign prostatic hyperplasia with regard to metabolic parameters and selected hormone levels. Int J Environ Res Public Health. 2017 Oct 30;14(11). DMC1TEV RU https://www.ncbi.nlm.nih.gov/pubmed/29084161 DMB6871 DI DMB6871 DMB6871 DN Testosterone enanthate DMB6871 MI DEPKLMQ DMB6871 MN Cytochrome P450 2B6 (CYP2B6) DMB6871 MT DME DMB6871 MA Metabolism DMB6871 RN Insights into CYP2B6-mediated drug-drug interactions. Acta Pharm Sin B. 2016 Sep;6(5):413-425. DMB6871 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=27709010 DMB6871 DI DMB6871 DMB6871 DN Testosterone enanthate DMB6871 MI DES5XRU DMB6871 MN Cytochrome P450 2C8 (CYP2C8) DMB6871 MT DME DMB6871 MA Metabolism DMB6871 RN Role of cytochrome P450 2C8 in drug metabolism and interactions. Pharmacol Rev. 2016 Jan;68(1):168-241. DMB6871 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=26721703 DMB6871 DI DMB6871 DMB6871 DN Testosterone enanthate DMB6871 MI DE5IED8 DMB6871 MN Cytochrome P450 2C9 (CYP2C9) DMB6871 MT DME DMB6871 MA Metabolism DMB6871 RN Human cytochrome p450 induction and inhibition potential of clevidipine and its primary metabolite h152/81. Drug Metab Dispos. 2006 May;34(5):734-7. DMB6871 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=16501008 DMB6871 DI DMB6871 DMB6871 DN Testosterone enanthate DMB6871 MI DEIBDNY DMB6871 MN Cytochrome P450 3A5 (CYP3A5) DMB6871 MT DME DMB6871 MA Metabolism DMB6871 RN In vitro metabolism of midazolam, triazolam, nifedipine, and testosterone by human liver microsomes and recombinant cytochromes p450: role of cyp3a4 and cyp3a5. Drug Metab Dispos. 2003 Jul;31(7):938-44. DMB6871 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=12814972 DMB6871 DI DMB6871 DMB6871 DN Testosterone enanthate DMB6871 MI DERD86B DMB6871 MN Cytochrome P450 3A7 (CYP3A7) DMB6871 MT DME DMB6871 MA Metabolism DMB6871 RN Steroid hydroxylation by human fetal CYP3A7 and human NADPH-cytochrome P450 reductase coexpressed in insect cells using baculovirus. Res Commun Mol Pathol Pharmacol. 1998 Apr;100(1):15-28. DMB6871 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=9644715 DMB6871 DI DMB6871 DMB6871 DN Testosterone enanthate DMB6871 MI DEGTFWK DMB6871 MN Mephenytoin 4-hydroxylase (CYP2C19) DMB6871 MT DME DMB6871 MA Metabolism DMB6871 RN Progesterone and testosterone hydroxylation by cytochromes P450 2C19, 2C9, and 3A4 in human liver microsomes. Arch Biochem Biophys. 1997 Oct 1;346(1):161-9. DMB6871 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=9328296 DMB6871 DI DMB6871 DMB6871 DN Testosterone enanthate DMB6871 MI DEON3ED DMB6871 MN Phosphodiesterase 7B (PDE7B) DMB6871 MT DME DMB6871 MA Metabolism DMB6871 RN PDE7B is involved in nandrolone decanoate hydrolysis in liver cytosol and its transcription is up-regulated by androgens in HepG2. Front Pharmacol. 2014 May 30;5:132. DMB6871 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=24910615 DMB6871 DI DMB6871 DMB6871 DN Testosterone enanthate DMB6871 MI DEOG15F DMB6871 MN Steroid 5-alpha-reductase 1 (SRD5A1) DMB6871 MT DME DMB6871 MA Metabolism DMB6871 RN Molecular analysis of the SRD5A1 and SRD5A2 genes in patients with benign prostatic hyperplasia with regard to metabolic parameters and selected hormone levels. Int J Environ Res Public Health. 2017 Oct 30;14(11). DMB6871 RU https://www.ncbi.nlm.nih.gov/pubmed/29084161 DMB6871 DI DMB6871 DMB6871 DN Testosterone enanthate DMB6871 MI DEPTJ3D DMB6871 MN Steroid 5-alpha-reductase 2 (SRD5A2) DMB6871 MT DME DMB6871 MA Metabolism DMB6871 RN Molecular analysis of the SRD5A1 and SRD5A2 genes in patients with benign prostatic hyperplasia with regard to metabolic parameters and selected hormone levels. Int J Environ Res Public Health. 2017 Oct 30;14(11). DMB6871 RU https://www.ncbi.nlm.nih.gov/pubmed/29084161 DMB6871 DI DMB6871 DMB6871 DN Testosterone enanthate DMB6871 MI DEZGVDW DMB6871 MN Steroid 5-alpha-reductase 3 (SRD5A3) DMB6871 MT DME DMB6871 MA Metabolism DMB6871 RN Molecular analysis of the SRD5A1 and SRD5A2 genes in patients with benign prostatic hyperplasia with regard to metabolic parameters and selected hormone levels. Int J Environ Res Public Health. 2017 Oct 30;14(11). DMB6871 RU https://www.ncbi.nlm.nih.gov/pubmed/29084161 DMZO10Y DI DMZO10Y DMZO10Y DN Testosterone Undecanoate DMZO10Y MI DEPKLMQ DMZO10Y MN Cytochrome P450 2B6 (CYP2B6) DMZO10Y MT DME DMZO10Y MA Metabolism DMZO10Y RN Insights into CYP2B6-mediated drug-drug interactions. Acta Pharm Sin B. 2016 Sep;6(5):413-425. DMZO10Y RU https://www.ncbi.nlm.nih.gov/pubmed/?term=27709010 DMZO10Y DI DMZO10Y DMZO10Y DN Testosterone Undecanoate DMZO10Y MI DES5XRU DMZO10Y MN Cytochrome P450 2C8 (CYP2C8) DMZO10Y MT DME DMZO10Y MA Metabolism DMZO10Y RN Role of cytochrome P450 2C8 in drug metabolism and interactions. Pharmacol Rev. 2016 Jan;68(1):168-241. DMZO10Y RU https://www.ncbi.nlm.nih.gov/pubmed/?term=26721703 DMZO10Y DI DMZO10Y DMZO10Y DN Testosterone Undecanoate DMZO10Y MI DE5IED8 DMZO10Y MN Cytochrome P450 2C9 (CYP2C9) DMZO10Y MT DME DMZO10Y MA Metabolism DMZO10Y RN Human cytochrome p450 induction and inhibition potential of clevidipine and its primary metabolite h152/81. Drug Metab Dispos. 2006 May;34(5):734-7. DMZO10Y RU https://www.ncbi.nlm.nih.gov/pubmed/?term=16501008 DMZO10Y DI DMZO10Y DMZO10Y DN Testosterone Undecanoate DMZO10Y MI DEIBDNY DMZO10Y MN Cytochrome P450 3A5 (CYP3A5) DMZO10Y MT DME DMZO10Y MA Metabolism DMZO10Y RN In vitro metabolism of midazolam, triazolam, nifedipine, and testosterone by human liver microsomes and recombinant cytochromes p450: role of cyp3a4 and cyp3a5. Drug Metab Dispos. 2003 Jul;31(7):938-44. DMZO10Y RU https://www.ncbi.nlm.nih.gov/pubmed/?term=12814972 DMZO10Y DI DMZO10Y DMZO10Y DN Testosterone Undecanoate DMZO10Y MI DERD86B DMZO10Y MN Cytochrome P450 3A7 (CYP3A7) DMZO10Y MT DME DMZO10Y MA Metabolism DMZO10Y RN Steroid hydroxylation by human fetal CYP3A7 and human NADPH-cytochrome P450 reductase coexpressed in insect cells using baculovirus. Res Commun Mol Pathol Pharmacol. 1998 Apr;100(1):15-28. DMZO10Y RU https://www.ncbi.nlm.nih.gov/pubmed/?term=9644715 DMZO10Y DI DMZO10Y DMZO10Y DN Testosterone Undecanoate DMZO10Y MI DEGTFWK DMZO10Y MN Mephenytoin 4-hydroxylase (CYP2C19) DMZO10Y MT DME DMZO10Y MA Metabolism DMZO10Y RN Progesterone and testosterone hydroxylation by cytochromes P450 2C19, 2C9, and 3A4 in human liver microsomes. Arch Biochem Biophys. 1997 Oct 1;346(1):161-9. DMZO10Y RU https://www.ncbi.nlm.nih.gov/pubmed/?term=9328296 DMYWQ0O DI DMYWQ0O DMYWQ0O DN Tetrabenazine DMYWQ0O MI DECB0K3 DMYWQ0O MN Cytochrome P450 2D6 (CYP2D6) DMYWQ0O MT DME DMYWQ0O MA Metabolism DMYWQ0O RN Role of tetrabenazine for Huntington's disease-associated chorea. Ann Pharmacother. 2010 Jun;44(6):1080-9. DMYWQ0O RU http://www.ncbi.nlm.nih.gov/pubmed/20442355 DMYWQ0O DI DMYWQ0O DMYWQ0O DN Tetrabenazine DMYWQ0O MI TTNZRI3 DMYWQ0O MN Synaptic vesicle amine transporter (SLC18A2) DMYWQ0O MT DTT DMYWQ0O MA Blocker DMYWQ0O RN Dopamine signaling is required for depolarization-induced slow current in cerebellar Purkinje cells. J Neurosci. 2009 Jul 1;29(26):8530-8. DMYWQ0O RU https://pubmed.ncbi.nlm.nih.gov/19571144 DM9J6C2 DI DM9J6C2 DM9J6C2 DN Tetracaine DM9J6C2 MI TT90XZ8 DM9J6C2 MN Voltage-gated sodium channel alpha Nav1.8 (SCN10A) DM9J6C2 MT DTT DM9J6C2 MA Inhibitor DM9J6C2 RN Heterologous expression and functional analysis of rat Nav1.8 (SNS) voltage-gated sodium channels in the dorsal root ganglion neuroblastoma cell line ND7-23. Neuropharmacology. 2004 Mar;46(3):425-38. DM9J6C2 RU https://pubmed.ncbi.nlm.nih.gov/14975698 DMZA017 DI DMZA017 DMZA017 DN Tetracycline DMZA017 MI DTI7UX6 DMZA017 MN Breast cancer resistance protein (ABCG2) DMZA017 MT DTP DMZA017 MA Substrate DMZA017 RN Arginine-482 is not essential for transport of antibiotics, primary bile acids and unconjugated sterols by the human breast cancer resistance protein (ABCG2). Biochem J. 2005 Jan 15;385(Pt 2):419-26. DMZA017 RU https://doi.org/10.1042/BJ20040791 DMZA017 DI DMZA017 DMZA017 DN Tetracycline DMZA017 MI DT0OC1Q DMZA017 MN Organic anion transporter 2 (SLC22A7) DMZA017 MT DTP DMZA017 MA Substrate DMZA017 RN Human organic anion transporters mediate the transport of tetracycline. Jpn J Pharmacol. 2002 Jan;88(1):69-76. DMZA017 RU http://www.ncbi.nlm.nih.gov/pubmed/11855680 DMZA017 DI DMZA017 DMZA017 DN Tetracycline DMZA017 MI DTVP67E DMZA017 MN Organic anion transporter 3 (SLC22A8) DMZA017 MT DTP DMZA017 MA Substrate DMZA017 RN Human organic anion transporters mediate the transport of tetracycline. Jpn J Pharmacol. 2002 Jan;88(1):69-76. DMZA017 RU http://www.ncbi.nlm.nih.gov/pubmed/11855680 DMZA017 DI DMZA017 DMZA017 DN Tetracycline DMZA017 MI DT06JWZ DMZA017 MN Organic anion transporter 4 (SLC22A11) DMZA017 MT DTP DMZA017 MA Substrate DMZA017 RN Human organic anion transporters mediate the transport of tetracycline. Jpn J Pharmacol. 2002 Jan;88(1):69-76. DMZA017 RU http://www.ncbi.nlm.nih.gov/pubmed/11855680 DMZA017 DI DMZA017 DMZA017 DN Tetracycline DMZA017 MI DTUGYRD DMZA017 MN P-glycoprotein 1 (ABCB1) DMZA017 MT DTP DMZA017 MA Substrate DMZA017 RN Mammalian drug efflux transporters of the ATP binding cassette (ABC) family in multidrug resistance: A review of the past decade. Cancer Lett. 2016 Jan 1;370(1):153-64. DMZA017 RU http://www.ncbi.nlm.nih.gov/pubmed/26499806 DMZA017 DI DMZA017 DMZA017 DN Tetracycline DMZA017 MI TTQ8KVI DMZA017 MN Staphylococcus 30S ribosomal subunit (Stap-coc pbp2) DMZA017 MT DTT DMZA017 MA Binder DMZA017 RN The glycylcyclines: a comparative review with the tetracyclines. Drugs. 2004;64(1):63-88. DMZA017 RU https://pubmed.ncbi.nlm.nih.gov/14723559 DMINZ4W DI DMINZ4W DMINZ4W DN Tetrahydrobiopterin DMINZ4W MI DER6XYF DMINZ4W MN Tryptophan 5-hydroxylase 2 (TPH2) DMINZ4W MT DME DMINZ4W MA Metabolism DMINZ4W RN Characterization of wild-type and mutant forms of human tryptophan hydroxylase 2. J Neurochem. 2007 Mar;100(6):1648-57. DMINZ4W RU https://www.ncbi.nlm.nih.gov/pubmed/?term=17181551 DMINZ4W DI DMINZ4W DMINZ4W DN Tetrahydrobiopterin DMINZ4W MI TTUHP71 DMINZ4W MN Tyrosine 3-monooxygenase (TH) DMINZ4W MT DTT DMINZ4W MA Cofactor DMINZ4W RN Biochemistry of postmortem brains in Parkinson's disease: historical overview and future prospects. J Neural Transm Suppl. 2007;(72):113-20. DMINZ4W RU https://pubmed.ncbi.nlm.nih.gov/17982884 DMH15UV DI DMH15UV DMH15UV DN Tetrahydrofolic acid DMH15UV MI TTQOD3G DMH15UV MN Folate receptor (FOLR) DMH15UV MT DTT DMH15UV MA Binder DMH15UV RN Common mutations at the homocysteine metabolism pathway and pediatric stroke. Thromb Res. 2001 Apr 15;102(2):115-20. DMH15UV RU https://pubmed.ncbi.nlm.nih.gov/11323021 DMT57WC DI DMT57WC DMT57WC DN Tetrahydrozoline DMT57WC MI TT2NUT5 DMT57WC MN Adrenergic receptor alpha-2C (ADRA2C) DMT57WC MT DTT DMT57WC MA Modulator DMT57WC RN Prolonged cardiovascular effects after unintentional ingestion of tetrahydrozoline. Clin Toxicol (Phila). 2008 Feb;46(2):171-2. DMT57WC RU https://pubmed.ncbi.nlm.nih.gov/18259967 DMWMPRG DI DMWMPRG DMWMPRG DN Tetrodotoxin DMWMPRG MI TTRK8B9 DMWMPRG MN Sodium channel unspecific (NaC) DMWMPRG MT DTT DMWMPRG MA Antagonist DMWMPRG RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMWMPRG RU http://phrma-docs.phrma.org/files/dmfile/MID_Neurological-Disorders-Drug-List_2018.pdf DMWMPRG DI DMWMPRG DMWMPRG DN Tetrodotoxin DMWMPRG MI TTIG65Q DMWMPRG MN Voltage-gated sodium channel (Nav) DMWMPRG MT DTT DMWMPRG MA Inhibitor DMWMPRG RN Antibodies and venom peptides: new modalities for ion channels. Nat Rev Drug Discov. 2019 May;18(5):339-357. DMWMPRG RU https://pubmed.ncbi.nlm.nih.gov/30728472 DMWMPRG DI DMWMPRG DMWMPRG DN Tetrodotoxin DMWMPRG MI TTZOVE0 DMWMPRG MN Voltage-gated sodium channel alpha Nav1.5 (SCN5A) DMWMPRG MT DTT DMWMPRG MA Blocker DMWMPRG RN Halothane attenuates the cerebroprotective action of several Na+ and Ca2+ channel blockers via reversal of their ion channel blockade. Eur J Pharmacol. 2002 Oct 4;452(2):175-81. DMWMPRG RU https://pubmed.ncbi.nlm.nih.gov/12354567 DMY62FC DI DMY62FC DMY62FC DN Tezacaftor And Ivacaftor DMY62FC MI TTRLZHP DMY62FC MN cAMP-dependent chloride channel (CFTR) DMY62FC MT DTT DMY62FC MA Binder DMY62FC RN 2018 FDA drug approvals.Nat Rev Drug Discov. 2019 Feb;18(2):85-89. DMY62FC RU https://pubmed.ncbi.nlm.nih.gov/30710142 DM70BU5 DI DM70BU5 DM70BU5 DN Thalidomide DM70BU5 MI DEJVYAZ DM70BU5 MN Cytochrome P450 2A6 (CYP2A6) DM70BU5 MT DME DM70BU5 MA Metabolism DM70BU5 RN Metabolism of thalidomide in human microsomes, cloned human cytochrome P-450 isozymes, and Hansen's disease patients. J Biochem Mol Toxicol. 2000;14(3):140-7. DM70BU5 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=10711629 DM70BU5 DI DM70BU5 DM70BU5 DN Thalidomide DM70BU5 MI DEPKLMQ DM70BU5 MN Cytochrome P450 2B6 (CYP2B6) DM70BU5 MT DME DM70BU5 MA Metabolism DM70BU5 RN Metabolism of thalidomide in human microsomes, cloned human cytochrome P-450 isozymes, and Hansen's disease patients. J Biochem Mol Toxicol. 2000;14(3):140-7. DM70BU5 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=10711629 DM70BU5 DI DM70BU5 DM70BU5 DN Thalidomide DM70BU5 MI DEZMWRE DM70BU5 MN Cytochrome P450 2C18 (CYP2C18) DM70BU5 MT DME DM70BU5 MA Metabolism DM70BU5 RN Thalidomide metabolism by the CYP2C subfamily. Clin Cancer Res. 2002 Jun;8(6):1964-73. DM70BU5 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=12060642 DM70BU5 DI DM70BU5 DM70BU5 DN Thalidomide DM70BU5 MI DES5XRU DM70BU5 MN Cytochrome P450 2C8 (CYP2C8) DM70BU5 MT DME DM70BU5 MA Metabolism DM70BU5 RN Thalidomide metabolism by the CYP2C subfamily. Clin Cancer Res. 2002 Jun;8(6):1964-73. DM70BU5 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=12060642 DM70BU5 DI DM70BU5 DM70BU5 DN Thalidomide DM70BU5 MI DE5IED8 DM70BU5 MN Cytochrome P450 2C9 (CYP2C9) DM70BU5 MT DME DM70BU5 MA Metabolism DM70BU5 RN Thalidomide metabolism by the CYP2C subfamily. Clin Cancer Res. 2002 Jun;8(6):1964-73. DM70BU5 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=12060642 DM70BU5 DI DM70BU5 DM70BU5 DN Thalidomide DM70BU5 MI DEVDYN7 DM70BU5 MN Cytochrome P450 2E1 (CYP2E1) DM70BU5 MT DME DM70BU5 MA Metabolism DM70BU5 RN Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. DM70BU5 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=19515014 DM70BU5 DI DM70BU5 DM70BU5 DN Thalidomide DM70BU5 MI DEIBDNY DM70BU5 MN Cytochrome P450 3A5 (CYP3A5) DM70BU5 MT DME DM70BU5 MA Metabolism DM70BU5 RN Human liver microsomal cytochrome P450 3A enzymes involved in thalidomide 5-hydroxylation and formation of a glutathione conjugate. Chem Res Toxicol. 2010 Jun 21;23(6):1018-24. DM70BU5 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=20443640 DM70BU5 DI DM70BU5 DM70BU5 DN Thalidomide DM70BU5 MI DEGTFWK DM70BU5 MN Mephenytoin 4-hydroxylase (CYP2C19) DM70BU5 MT DME DM70BU5 MA Metabolism DM70BU5 RN Pharmacogenetic associations of CYP2C19 genotype with in vivo metabolisms and pharmacological effects of thalidomide. Cancer Biol Ther. 2002 Nov-Dec;1(6):669-73. DM70BU5 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=12642692 DM70BU5 DI DM70BU5 DM70BU5 DN Thalidomide DM70BU5 MI DE073H6 DM70BU5 MN Prostaglandin G/H synthase 1 (COX-1) DM70BU5 MT DME DM70BU5 MA Metabolism DM70BU5 RN Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. DM70BU5 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=19515014 DM70BU5 DI DM70BU5 DM70BU5 DN Thalidomide DM70BU5 MI TTF8CQI DM70BU5 MN Tumor necrosis factor (TNF) DM70BU5 MT DTT DM70BU5 MA Inhibitor DM70BU5 RN Efficacy of different thalidomide regimens for patients with multiple myeloma and its relationship with TNF-alpha level. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2008 Dec;16(6):1312-5. DM70BU5 RU https://pubmed.ncbi.nlm.nih.gov/19099634 DMM8D3F DI DMM8D3F DMM8D3F DN Theobromine DMM8D3F MI DEJGDUW DMM8D3F MN Cytochrome P450 1A2 (CYP1A2) DMM8D3F MT DME DMM8D3F MA Metabolism DMM8D3F RN Cytochrome P450 isoform selectivity in human hepatic theobromine metabolism. Br J Clin Pharmacol. 1999 Mar;47(3):299-305. DMM8D3F RU https://www.ncbi.nlm.nih.gov/pubmed/?term=10215755 DMM8D3F DI DMM8D3F DMM8D3F DN Theobromine DMM8D3F MI DEVDYN7 DMM8D3F MN Cytochrome P450 2E1 (CYP2E1) DMM8D3F MT DME DMM8D3F MA Metabolism DMM8D3F RN Cytochrome P450 isoform selectivity in human hepatic theobromine metabolism. Br J Clin Pharmacol. 1999 Mar;47(3):299-305. DMM8D3F RU https://www.ncbi.nlm.nih.gov/pubmed/?term=10215755 DMRJFN9 DI DMRJFN9 DMRJFN9 DN Theophylline DMRJFN9 MI TTSLI08 DMRJFN9 MN Adenosine receptor (ADOR) DMRJFN9 MT DTT DMRJFN9 MA Antagonist DMRJFN9 RN Emerging adenosine receptor agonists. Expert Opin Emerg Drugs. 2007 Sep;12(3):479-92. DMRJFN9 RU https://pubmed.ncbi.nlm.nih.gov/17874974 DMRJFN9 DI DMRJFN9 DMRJFN9 DN Theophylline DMRJFN9 MI DE6OQ3W DMRJFN9 MN Cytochrome P450 1A1 (CYP1A1) DMRJFN9 MT DME DMRJFN9 MA Metabolism DMRJFN9 RN Specificity of substrate and inhibitor probes for human cytochromes P450 1A1 and 1A2. J Pharmacol Exp Ther. 1993 Apr;265(1):401-7. DMRJFN9 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=8474022 DMRJFN9 DI DMRJFN9 DMRJFN9 DN Theophylline DMRJFN9 MI DEJGDUW DMRJFN9 MN Cytochrome P450 1A2 (CYP1A2) DMRJFN9 MT DME DMRJFN9 MA Metabolism DMRJFN9 RN Association between common CYP1A2 polymorphisms and theophylline metabolism in non-smoking healthy volunteers. Basic Clin Pharmacol Toxicol. 2013 Apr;112(4):257-63. DMRJFN9 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=23167834 DMRJFN9 DI DMRJFN9 DMRJFN9 DN Theophylline DMRJFN9 MI DE9QHP6 DMRJFN9 MN Cytochrome P450 1B1 (CYP1B1) DMRJFN9 MT DME DMRJFN9 MA Metabolism DMRJFN9 RN Oxidation of xenobiotics by recombinant human cytochrome P450 1B1. Drug Metab Dispos. 1997 May;25(5):617-22. DMRJFN9 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=9152602 DMRJFN9 DI DMRJFN9 DMRJFN9 DN Theophylline DMRJFN9 MI DECB0K3 DMRJFN9 MN Cytochrome P450 2D6 (CYP2D6) DMRJFN9 MT DME DMRJFN9 MA Metabolism DMRJFN9 RN Characterization of human cytochromes P450 involved in theophylline 8-hydroxylation. Biochem Pharmacol. 1995 Jul 17;50(2):205-11. DMRJFN9 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=7632164 DMRJFN9 DI DMRJFN9 DMRJFN9 DN Theophylline DMRJFN9 MI DEVDYN7 DMRJFN9 MN Cytochrome P450 2E1 (CYP2E1) DMRJFN9 MT DME DMRJFN9 MA Metabolism DMRJFN9 RN Construction and assessment of models of CYP2E1: predictions of metabolism from docking, molecular dynamics, and density functional theoretical calculations. J Med Chem. 2003 Apr 24;46(9):1645-60. DMRJFN9 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=12699383 DMRJFN9 DI DMRJFN9 DMRJFN9 DN Theophylline DMRJFN9 MI DE4LYSA DMRJFN9 MN Cytochrome P450 3A4 (CYP3A4) DMRJFN9 MT DME DMRJFN9 MA Metabolism DMRJFN9 RN Characterization of human cytochromes P450 involved in theophylline 8-hydroxylation. Biochem Pharmacol. 1995 Jul 17;50(2):205-11. DMRJFN9 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=7632164 DMRJFN9 DI DMRJFN9 DMRJFN9 DN Theophylline DMRJFN9 MI DT0OC1Q DMRJFN9 MN Organic anion transporter 2 (SLC22A7) DMRJFN9 MT DTP DMRJFN9 MA Substrate DMRJFN9 RN Possible involvement of organic anion transporter 2 on the interaction of theophylline with erythromycin in the human liver. Drug Metab Dispos. 2005 May;33(5):619-22. DMRJFN9 RU http://www.ncbi.nlm.nih.gov/pubmed/15708966 DM7YCK3 DI DM7YCK3 DM7YCK3 DN Thiabendazole DM7YCK3 MI TTHDSE2 DM7YCK3 MN Bacterial Fumarate reductase flavoprotein (Bact frdA) DM7YCK3 MT DTT DM7YCK3 MA Inhibitor DM7YCK3 RN Fumarate reductase is essential for Helicobacter pylori colonization of the mouse stomach. Microb Pathog. 2000 Nov;29(5):279-87. DM7YCK3 RU https://pubmed.ncbi.nlm.nih.gov/11031122 DM7YCK3 DI DM7YCK3 DM7YCK3 DN Thiabendazole DM7YCK3 MI DEJGDUW DM7YCK3 MN Cytochrome P450 1A2 (CYP1A2) DM7YCK3 MT DME DM7YCK3 MA Metabolism DM7YCK3 RN Synthetic and natural compounds that interact with human cytochrome P450 1A2 and implications in drug development. Curr Med Chem. 2009;16(31):4066-218. DM7YCK3 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=19754423 DMDRKH2 DI DMDRKH2 DMDRKH2 DN Thiamphenicol DMDRKH2 MI TTLFGBV DMDRKH2 MN Bacterial 23S ribosomal RNA (Bact 23S rRNA) DMDRKH2 MT DTT DMDRKH2 MA Modulator DMDRKH2 RN The fused TrpEG from Streptomyces venezuelae is an anthranilate synthase, not a 2-amino-2-deoxyisochorismate [corrected] (ADIC) synthase. Ethn Dis. 2008 Spring;18(2 Suppl 2):S2-9-13. DMDRKH2 RU https://pubmed.ncbi.nlm.nih.gov/18646313 DMDRKH2 DI DMDRKH2 DMDRKH2 DN Thiamphenicol DMDRKH2 MI DTUGYRD DMDRKH2 MN P-glycoprotein 1 (ABCB1) DMDRKH2 MT DTP DMDRKH2 MA Substrate DMDRKH2 RN Active Mediated Transport of Chloramphenicol and Thiamphenicol in a Calu-3 Lung Epithelial Cell Model. J Pharm Sci. 2018 Apr;107(4):1178-1184. DMDRKH2 RU http://www.ncbi.nlm.nih.gov/pubmed/29221992 DMHDF7B DI DMHDF7B DMHDF7B DN Thiamylal DMHDF7B MI DE5IED8 DMHDF7B MN Cytochrome P450 2C9 (CYP2C9) DMHDF7B MT DME DMHDF7B MA Metabolism DMHDF7B RN Protein binding and the metabolism of thiamylal enantiomers in vitro. Anesth Analg. 2000 Sep;91(3):736-40. DMHDF7B RU https://www.ncbi.nlm.nih.gov/pubmed/?term=10960410 DMHDF7B DI DMHDF7B DMHDF7B DN Thiamylal DMHDF7B MI DEVDYN7 DMHDF7B MN Cytochrome P450 2E1 (CYP2E1) DMHDF7B MT DME DMHDF7B MA Metabolism DMHDF7B RN Effects of premedication medicines on the formation of the CYP3A4-dependent metabolite of ropivacaine, 2', 6'-Pipecoloxylidide, on human liver microsomes in vitro. Basic Clin Pharmacol Toxicol. 2006 Feb;98(2):181-3. DMHDF7B RU https://www.ncbi.nlm.nih.gov/pubmed/?term=16445592 DMHDF7B DI DMHDF7B DMHDF7B DN Thiamylal DMHDF7B MI DE4LYSA DMHDF7B MN Cytochrome P450 3A4 (CYP3A4) DMHDF7B MT DME DMHDF7B MA Metabolism DMHDF7B RN Protein binding and the metabolism of thiamylal enantiomers in vitro. Anesth Analg. 2000 Sep;91(3):736-40. DMHDF7B RU https://www.ncbi.nlm.nih.gov/pubmed/?term=10960410 DMHDF7B DI DMHDF7B DMHDF7B DN Thiamylal DMHDF7B MI TTEX6LM DMHDF7B MN GABA(A) receptor gamma-3 (GABRG3) DMHDF7B MT DTT DMHDF7B MA Modulator DMHDF7B RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. DMHDF7B RU https://www.fda.gov/ DMC1NBW DI DMC1NBW DMC1NBW DN Thiazolidinedione DMC1NBW MI TTZMAO3 DMC1NBW MN Peroxisome proliferator-activated receptor gamma (PPAR-gamma) DMC1NBW MT DTT DMC1NBW MA Agonist DMC1NBW RN Functional PPAR-gamma receptor is a novel therapeutic target for ACTH-secreting pituitary adenomas. Nat Med. 2002 Nov;8(11):1281-7. DMC1NBW RU https://pubmed.ncbi.nlm.nih.gov/12379847 DMU3IET DI DMU3IET DMU3IET DN Thiethylperazine DMU3IET MI TTEX248 DMU3IET MN Dopamine D2 receptor (D2R) DMU3IET MT DTT DMU3IET MA Antagonist DMU3IET RN Antiemetic specificity of dopamine antagonists. Psychopharmacology (Berl). 1982;78(3):210-3. DMU3IET RU https://pubmed.ncbi.nlm.nih.gov/6130555 DMEPWYA DI DMEPWYA DMEPWYA DN THIOCOLCHICOSIDE DMEPWYA MI TT1MPAY DMEPWYA MN GABA(A) receptor alpha-1 (GABRA1) DMEPWYA MT DTT DMEPWYA MA Inhibitor DMEPWYA RN 3-demethoxy-3-glycosylaminothiocolchicines: Synthesis of a new class of putative muscle relaxant compounds. J Med Chem. 2006 Sep 7;49(18):5571-7. DMEPWYA RU https://pubmed.ncbi.nlm.nih.gov/16942030 DMEPWYA DI DMEPWYA DMEPWYA DN THIOCOLCHICOSIDE DMEPWYA MI TTZA1NY DMEPWYA MN GABA(A) receptor beta-2 (GABRB2) DMEPWYA MT DTT DMEPWYA MA Inhibitor DMEPWYA RN 3-demethoxy-3-glycosylaminothiocolchicines: Synthesis of a new class of putative muscle relaxant compounds. J Med Chem. 2006 Sep 7;49(18):5571-7. DMEPWYA RU https://pubmed.ncbi.nlm.nih.gov/16942030 DMEPWYA DI DMEPWYA DMEPWYA DN THIOCOLCHICOSIDE DMEPWYA MI TT06RH5 DMEPWYA MN GABA(A) receptor gamma-2 (GABRG2) DMEPWYA MT DTT DMEPWYA MA Inhibitor DMEPWYA RN 3-demethoxy-3-glycosylaminothiocolchicines: Synthesis of a new class of putative muscle relaxant compounds. J Med Chem. 2006 Sep 7;49(18):5571-7. DMEPWYA RU https://pubmed.ncbi.nlm.nih.gov/16942030 DMEPWYA DI DMEPWYA DMEPWYA DN THIOCOLCHICOSIDE DMEPWYA MI TTNJYV2 DMEPWYA MN Gamma-aminobutyric acid receptor (GAR) DMEPWYA MT DTT DMEPWYA MA Inhibitor DMEPWYA RN 3-demethoxy-3-glycosylaminothiocolchicines: Synthesis of a new class of putative muscle relaxant compounds. J Med Chem. 2006 Sep 7;49(18):5571-7. DMEPWYA RU https://pubmed.ncbi.nlm.nih.gov/16942030 DMEPWYA DI DMEPWYA DMEPWYA DN THIOCOLCHICOSIDE DMEPWYA MI TTZ8EM9 DMEPWYA MN Glycine receptor (GlyR) DMEPWYA MT DTT DMEPWYA MA Inhibitor DMEPWYA RN 3-demethoxy-3-glycosylaminothiocolchicines: Synthesis of a new class of putative muscle relaxant compounds. J Med Chem. 2006 Sep 7;49(18):5571-7. DMEPWYA RU https://pubmed.ncbi.nlm.nih.gov/16942030 DMEPWYA DI DMEPWYA DMEPWYA DN THIOCOLCHICOSIDE DMEPWYA MI TTF45NW DMEPWYA MN Strychnine-binding glycine receptor (GLRA1) DMEPWYA MT DTT DMEPWYA MA Inhibitor DMEPWYA RN 3-demethoxy-3-glycosylaminothiocolchicines: Synthesis of a new class of putative muscle relaxant compounds. J Med Chem. 2006 Sep 7;49(18):5571-7. DMEPWYA RU https://pubmed.ncbi.nlm.nih.gov/16942030 DM7NKEV DI DM7NKEV DM7NKEV DN Thioguanine DM7NKEV MI DTI7UX6 DM7NKEV MN Breast cancer resistance protein (ABCG2) DM7NKEV MT DTP DM7NKEV MA Substrate DM7NKEV RN ABC transporters and their role in nucleoside and nucleotide drug resistance. Biochem Pharmacol. 2012 Apr 15;83(8):1073-83. DM7NKEV RU https://doi.org/10.1016/j.bcp.2011.12.042 DM7NKEV DI DM7NKEV DM7NKEV DN Thioguanine DM7NKEV MI DT4YL5R DM7NKEV MN Concentrative Na(+)-nucleoside cotransporter 3 (SLC28A3) DM7NKEV MT DTP DM7NKEV MA Substrate DM7NKEV RN Involvement of the concentrative nucleoside transporter 3 and equilibrative nucleoside transporter 2 in the resistance of T-lymphoblastic cell lines to thiopurines. Biochem Biophys Res Commun. 2006 Apr 28;343(1):208-15. DM7NKEV RU http://www.ncbi.nlm.nih.gov/pubmed/16530731 DM7NKEV DI DM7NKEV DM7NKEV DN Thioguanine DM7NKEV MI DEVXTP5 DM7NKEV MN Hypoxanthine phosphoribosyltransferase (HPRT1) DM7NKEV MT DME DM7NKEV MA Metabolism DM7NKEV RN Qualitative and quantitative difference in mutation induction between carbon- and neon-ion beams in normal human cells. Biol Sci Space. 2003 Dec;17(4):302-6. DM7NKEV RU https://www.ncbi.nlm.nih.gov/pubmed/?term=15136753 DM7NKEV DI DM7NKEV DM7NKEV DN Thioguanine DM7NKEV MI TTCAQMW DM7NKEV MN Inosine-5'-monophosphate dehydrogenase (IMPDH) DM7NKEV MT DTT DM7NKEV MA Intercalator DM7NKEV RN Immune effector cells produce lethal DNA damage in cells treated with a thiopurine. Cancer Res. 2009 Mar 15;69(6):2393-9. DM7NKEV RU https://pubmed.ncbi.nlm.nih.gov/19244103 DM7NKEV DI DM7NKEV DM7NKEV DN Thioguanine DM7NKEV MI DTCSGPB DM7NKEV MN Multidrug resistance-associated protein 4 (ABCC4) DM7NKEV MT DTP DM7NKEV MA Substrate DM7NKEV RN Multidrug resistance protein 4 (MRP4/ABCC4) mediates efflux of bimane-glutathione. Int J Biochem Cell Biol. 2004 Feb;36(2):247-57. DM7NKEV RU http://www.ncbi.nlm.nih.gov/pubmed/14643890 DM7NKEV DI DM7NKEV DM7NKEV DN Thioguanine DM7NKEV MI DEFQ8VO DM7NKEV MN Thiopurine methyltransferase (TPMT) DM7NKEV MT DME DM7NKEV MA Metabolism DM7NKEV RN Usefulness of thiopurine methyltransferase and thiopurine metabolite analysis in clinical practice in patients with inflammatory bowel diseases. Acta Gastroenterol Belg. 2010 Jul-Sep;73(3):331-5. DM7NKEV RU https://www.ncbi.nlm.nih.gov/pubmed/?term=21086934 DMGP8AX DI DMGP8AX DMGP8AX DN Thiopental DMGP8AX MI TTDP1UC DMGP8AX MN Fatty acid amide hydrolase (FAAH) DMGP8AX MT DTT DMGP8AX MA Inhibitor DMGP8AX RN The general anesthetic propofol increases brain N-arachidonylethanolamine (anandamide) content and inhibits fatty acid amide hydrolase. Br J Pharmacol. 2003 Jul;139(5):1005-13. DMGP8AX RU https://pubmed.ncbi.nlm.nih.gov/12839875 DMGP8AX DI DMGP8AX DMGP8AX DN Thiopental DMGP8AX MI DEGTFWK DMGP8AX MN Mephenytoin 4-hydroxylase (CYP2C19) DMGP8AX MT DME DMGP8AX MA Metabolism DMGP8AX RN Lerman J. (2014). Neonatal Anesthesia. Springer. DMGP8AX RU https://link.springer.com/book/10.1007%2F978-1-4419-6041-2 DM35M8J DI DM35M8J DM35M8J DN Thioridazine DM35M8J MI DECB0K3 DM35M8J MN Cytochrome P450 2D6 (CYP2D6) DM35M8J MT DME DM35M8J MA Metabolism DM35M8J RN Thioridazine steady-state plasma concentrations are influenced by tobacco smoking and CYP2D6, but not by the CYP2C9 genotype. Eur J Clin Pharmacol. 2003 May;59(1):45-50. DM35M8J RU https://www.ncbi.nlm.nih.gov/pubmed/?term=12682803 DM35M8J DI DM35M8J DM35M8J DN Thioridazine DM35M8J MI TTEX248 DM35M8J MN Dopamine D2 receptor (D2R) DM35M8J MT DTT DM35M8J MA Antagonist DM35M8J RN Antipsychotics lack alpha 1A/B adrenoceptor subtype selectivity in the rat. Eur Neuropsychopharmacol. 2005 Mar;15(2):231-4. DM35M8J RU https://pubmed.ncbi.nlm.nih.gov/15695070 DM35M8J DI DM35M8J DM35M8J DN Thioridazine DM35M8J MI DEGTFWK DM35M8J MN Mephenytoin 4-hydroxylase (CYP2C19) DM35M8J MT DME DM35M8J MA Metabolism DM35M8J RN CYP2J2 and CYP2C19 are the major enzymes responsible for metabolism of albendazole and fenbendazole in human liver microsomes and recombinant P450 assay systems. Antimicrob Agents Chemother. 2013 Nov;57(11):5448-56. DM35M8J RU https://www.ncbi.nlm.nih.gov/pubmed/?term=23959307 DM35M8J DI DM35M8J DM35M8J DN Thioridazine DM35M8J MI DTUGYRD DM35M8J MN P-glycoprotein 1 (ABCB1) DM35M8J MT DTP DM35M8J MA Substrate DM35M8J RN Improving the prediction of the brain disposition for orally administered drugs using BDDCS. Adv Drug Deliv Rev. 2012 Jan;64(1):95-109. DM35M8J RU https://doi.org/10.1016/j.addr.2011.12.008 DMIZKOP DI DMIZKOP DMIZKOP DN Thiotepa DMIZKOP MI DE4LYSA DMIZKOP MN Cytochrome P450 3A4 (CYP3A4) DMIZKOP MT DME DMIZKOP MA Metabolism DMIZKOP RN Cytochrome P450 isozymes 3A4 and 2B6 are involved in the in vitro human metabolism of thiotepa to TEPA. Cancer Chemother Pharmacol. 2002 Jun;49(6):461-7. DMIZKOP RU https://www.ncbi.nlm.nih.gov/pubmed/?term=12107550 DMIZKOP DI DMIZKOP DMIZKOP DN Thiotepa DMIZKOP MI DE4ZHS1 DMIZKOP MN Glutathione S-transferase alpha-1 (GSTA1) DMIZKOP MT DME DMIZKOP MA Metabolism DMIZKOP RN Differential catalytic efficiency of allelic variants of human glutathione S-transferase Pi in catalyzing the glutathione conjugation of thiotepa. Arch Biochem Biophys. 1999 Jun 1;366(1):89-94. DMIZKOP RU https://www.ncbi.nlm.nih.gov/pubmed/?term=10334868 DMDINC4 DI DMDINC4 DMDINC4 DN Thiothixene DMDINC4 MI DEJGDUW DMDINC4 MN Cytochrome P450 1A2 (CYP1A2) DMDINC4 MT DME DMDINC4 MA Metabolism DMDINC4 RN In vitro analysis of factors influencing CYP1A2 expression as potential determinants of interindividual variation. Pharmacol Res Perspect. 2017 Mar 2;5(2):e00299. DMDINC4 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=28357125 DMDINC4 DI DMDINC4 DMDINC4 DN Thiothixene DMDINC4 MI TTEX248 DMDINC4 MN Dopamine D2 receptor (D2R) DMDINC4 MT DTT DMDINC4 MA Antagonist DMDINC4 RN Dopaminergic stimulation of cAMP accumulation in cultured rat mesangial cells. Am J Physiol. 1987 Aug;253(2 Pt 2):H358-64. DMDINC4 RU https://pubmed.ncbi.nlm.nih.gov/3039860 DM2P6VD DI DM2P6VD DM2P6VD DN Thrombin/fibrinogen matrix patch DM2P6VD MI TTWODQF DM2P6VD MN Fibrin (FG) DM2P6VD MT DTT DM2P6VD MA Modulator DM2P6VD RN Fibrin sealant patch for repair of acute type a aortic dissection. J Card Surg. 2013 Nov;28(6):736-41. DM2P6VD RU https://pubmed.ncbi.nlm.nih.gov/23957708 DMJ47QC DI DMJ47QC DMJ47QC DN Thyrotropin DMJ47QC MI TT6NYJA DMJ47QC MN Thyrotropin receptor (TSHR) DMJ47QC MT DTT DMJ47QC MA Modulator DMJ47QC RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. DMJ47QC RU https://www.fda.gov/ DMMYLTI DI DMMYLTI DMMYLTI DN Thyrotropin Alfa DMMYLTI MI TT6NYJA DMMYLTI MN Thyrotropin receptor (TSHR) DMMYLTI MT DTT DMMYLTI MA Binder DMMYLTI RN Pharmacological profiles and clinical effects of recombinant human thyrotropin alfa (Thyrogen) Intramuscular Injection 0.9 mg). Nippon Yakurigaku Zasshi. 2009 Jul;134(1):28-34. DMMYLTI RU https://pubmed.ncbi.nlm.nih.gov/19602784 DMKSQG0 DI DMKSQG0 DMKSQG0 DN Tiagabine DMKSQG0 MI DE4LYSA DMKSQG0 MN Cytochrome P450 3A4 (CYP3A4) DMKSQG0 MT DME DMKSQG0 MA Metabolism DMKSQG0 RN Enzyme induction and inhibition by new antiepileptic drugs: a review of human studies. Fundam Clin Pharmacol. 2000 Jul-Aug;14(4):301-19. DMKSQG0 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=11030437 DMKSQG0 DI DMKSQG0 DMKSQG0 DN Tiagabine DMKSQG0 MI TTPRKM0 DMKSQG0 MN GABA transporter GAT-1 (SLC6A1) DMKSQG0 MT DTT DMKSQG0 MA Inhibitor DMKSQG0 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 929). DMKSQG0 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=929 DMKSQG0 DI DMKSQG0 DMKSQG0 DN Tiagabine DMKSQG0 MI TTV9MQG DMKSQG0 MN Gamma-aminobutyric acid uptake (GABAU) DMKSQG0 MT DTT DMKSQG0 MA Inhibitor DMKSQG0 RN Glutamate- and GABA-based CNS therapeutics. Curr Opin Pharmacol. 2006 Feb;6(1):7-17. DMKSQG0 RU https://pubmed.ncbi.nlm.nih.gov/16377242 DMKSQG0 DI DMKSQG0 DMKSQG0 DN Tiagabine DMKSQG0 MI DEYGVN4 DMKSQG0 MN UDP-glucuronosyltransferase 1A1 (UGT1A1) DMKSQG0 MT DME DMKSQG0 MA Metabolism DMKSQG0 RN Actual and Predicted Pharmacokinetic Interactions Between Anticonvulsants and Antiretrovirals. 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DM23D7J RU https://pubmed.ncbi.nlm.nih.gov/2277128 DM5JWV9 DI DM5JWV9 DM5JWV9 DN Tiazofurin DM5JWV9 MI TTL7C8Q DM5JWV9 MN Inosine-5'-monophosphate dehydrogenase 1 (IMPDH1) DM5JWV9 MT DTT DM5JWV9 MA Inhibitor DM5JWV9 RN In vitro and in vivo antiproliferative activity of IPCAR, a new pyrazole nucleoside analog. Anticancer Res. 1998 Jul-Aug;18(4A):2623-30. DM5JWV9 RU https://pubmed.ncbi.nlm.nih.gov/9703919 DM5JWV9 DI DM5JWV9 DM5JWV9 DN Tiazofurin DM5JWV9 MI DENV24I DM5JWV9 MN Nicotinamide riboside kinase 1 (NRK1) DM5JWV9 MT DME DM5JWV9 MA Metabolism DM5JWV9 RN Nicotinamide riboside kinase structures reveal new pathways to NAD+. PLoS Biol. 2007 Oct 2;5(10):e263. DM5JWV9 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=17914902 DM5JWV9 DI DM5JWV9 DM5JWV9 DN Tiazofurin DM5JWV9 MI DE8DJ3N DM5JWV9 MN Nicotinamide riboside kinase 2 (NRK2) DM5JWV9 MT DME DM5JWV9 MA Metabolism DM5JWV9 RN Nicotinamide riboside kinase structures reveal new pathways to NAD+. PLoS Biol. 2007 Oct 2;5(10):e263. DM5JWV9 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=17914902 DM78XFG DI DM78XFG DM78XFG DN Tibolone DM78XFG MI DEN0GVQ DM78XFG MN Beta-HSD adrenal and gonadal type (HSD3B2) DM78XFG MT DME DM78XFG MA Metabolism DM78XFG RN Tibolone: a unique version of hormone replacement therapy. Ann Pharmacother. 2004 May;38(5):874-81. DM78XFG RU http://citeseerx.ist.psu.edu/viewdoc/download?doi=10.1.1.919.2384&rep=rep1&type=pdf DM78XFG DI DM78XFG DM78XFG DN Tibolone DM78XFG MI DERDQWN DM78XFG MN Dihydrotestosterone oxidoreductase (HSD3B1) DM78XFG MT DME DM78XFG MA Metabolism DM78XFG RN Tibolone: a unique version of hormone replacement therapy. Ann Pharmacother. 2004 May;38(5):874-81. DM78XFG RU http://citeseerx.ist.psu.edu/viewdoc/download?doi=10.1.1.919.2384&rep=rep1&type=pdf DM78XFG DI DM78XFG DM78XFG DN Tibolone DM78XFG MI DEYWLRK DM78XFG MN Sulfotransferase 1A1 (SULT1A1) DM78XFG MT DME DM78XFG MA Metabolism DM78XFG RN Sulfation of tibolone metabolites by human postmenopausal liver and small intestinal sulfotransferases (SULTs). Steroids. 2006 May;71(5):343-51. DM78XFG RU https://www.ncbi.nlm.nih.gov/pubmed/?term=16360722 DM4ME02 DI DM4ME02 DM4ME02 DN Ticarcillin DM4ME02 MI TTJP4SM DM4ME02 MN Bacterial Penicillin binding protein (Bact PBP) DM4ME02 MT DTT DM4ME02 MA Binder DM4ME02 RN Activities of antibiotics against methicillin-resistant Staphylococcus aureus with particular reference to synergetic effect between ticarcillin and fosfomycin on penicillinase non-producing methicillin-resistant S. aureus. Jpn J Antibiot. 1993 Jun;46(6):421-7. DM4ME02 RU https://pubmed.ncbi.nlm.nih.gov/8360977 DM4ME02 DI DM4ME02 DM4ME02 DN Ticarcillin DM4ME02 MI DED0TBR DM4ME02 MN Beta-lactamase (blaB) DM4ME02 MT DME DM4ME02 MA Metabolism DM4ME02 RN Effect of CO2 on susceptibilities of anaerobes to erythromycin, azithromycin, clarithromycin, and roxithromycin. Antimicrob Agents Chemother. 1994 Feb;38(2):211-6. DM4ME02 RU https://pubmed.ncbi.nlm.nih.gov/8192445 DM4ME02 DI DM4ME02 DM4ME02 DN Ticarcillin DM4ME02 MI DERGEVU DM4ME02 MN Beta-lactamase (blaB) DM4ME02 MT DME DM4ME02 MA Metabolism DM4ME02 RN Effect of CO2 on susceptibilities of anaerobes to erythromycin, azithromycin, clarithromycin, and roxithromycin. Antimicrob Agents Chemother. 1994 Feb;38(2):211-6. DM4ME02 RU https://pubmed.ncbi.nlm.nih.gov/8192445 DM4ME02 DI DM4ME02 DM4ME02 DN Ticarcillin DM4ME02 MI DEQMISO DM4ME02 MN Beta-lactamase (blaB) DM4ME02 MT DME DM4ME02 MA Metabolism DM4ME02 RN Effect of CO2 on susceptibilities of anaerobes to erythromycin, azithromycin, clarithromycin, and roxithromycin. Antimicrob Agents Chemother. 1994 Feb;38(2):211-6. DM4ME02 RU https://pubmed.ncbi.nlm.nih.gov/8192445 DM4ME02 DI DM4ME02 DM4ME02 DN Ticarcillin DM4ME02 MI DEHFJ4G DM4ME02 MN Beta-lactamase (blaB) DM4ME02 MT DME DM4ME02 MA Metabolism DM4ME02 RN Effect of CO2 on susceptibilities of anaerobes to erythromycin, azithromycin, clarithromycin, and roxithromycin. Antimicrob Agents Chemother. 1994 Feb;38(2):211-6. 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DM4ME02 RU https://pubmed.ncbi.nlm.nih.gov/2221864 DM4ME02 DI DM4ME02 DM4ME02 DN Ticarcillin DM4ME02 MI DEF01WC DM4ME02 MN Beta-lactamase (blaB) DM4ME02 MT DME DM4ME02 MA Metabolism DM4ME02 RN Beta-lactamase activity in Chromobacterium violaceum. J Infect Dis. 1976 Sep;134(3):290-3. DM4ME02 RU https://pubmed.ncbi.nlm.nih.gov/977998 DMO946V DI DMO946V DMO946V DN Ticlopidine DMO946V MI DECB0K3 DMO946V MN Cytochrome P450 2D6 (CYP2D6) DMO946V MT DME DMO946V MA Metabolism DMO946V RN Effect of health foods on cytochrome P450-mediated drug metabolism. J Pharm Health Care Sci. 2017 May 10;3:14. DMO946V RU https://www.ncbi.nlm.nih.gov/pubmed/?term=28496987 DMO946V DI DMO946V DMO946V DN Ticlopidine DMO946V MI DEGTFWK DMO946V MN Mephenytoin 4-hydroxylase (CYP2C19) DMO946V MT DME DMO946V MA Metabolism DMO946V RN Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. DMO946V RU https://www.ncbi.nlm.nih.gov/pubmed/?term=19515014 DMO946V DI DMO946V DMO946V DN Ticlopidine DMO946V MI DEA3U9Y DMO946V MN Myeloperoxidase (MPO) DMO946V MT DME DMO946V MA Metabolism DMO946V RN Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. DMO946V RU https://www.ncbi.nlm.nih.gov/pubmed/?term=19515014 DMO946V DI DMO946V DMO946V DN Ticlopidine DMO946V MI TTQL5VC DMO946V MN Platelet-activating factor receptor (PTAFR) DMO946V MT DTT DMO946V MA Modulator DMO946V RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. DMO946V RU https://www.fda.gov/ DMLE7IO DI DMLE7IO DMLE7IO DN Tigecycline DMLE7IO MI TTQ8KVI DMLE7IO MN Staphylococcus 30S ribosomal subunit (Stap-coc pbp2) DMLE7IO MT DTT DMLE7IO MA Binder DMLE7IO RN Tigecycline: first of a new class of antimicrobial agents. Pharmacotherapy. 2006 Aug;26(8):1099-110. DMLE7IO RU https://pubmed.ncbi.nlm.nih.gov/16863487 DMLW9HG DI DMLW9HG DMLW9HG DN Tildrakizumab DMLW9HG MI TTC1GLB DMLW9HG MN Interleukin-23 (IL23) DMLW9HG MT DTT DMLW9HG MA Modulator DMLW9HG RN 2018 FDA drug approvals.Nat Rev Drug Discov. 2019 Feb;18(2):85-89. DMLW9HG RU https://pubmed.ncbi.nlm.nih.gov/30710142 DMLW9HG DI DMLW9HG DMLW9HG DN Tildrakizumab DMLW9HG MI TTQTX98 DMLW9HG MN Interleukin-37 (IL37) DMLW9HG MT DTT DMLW9HG MA Inhibitor DMLW9HG RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMLW9HG RU http://phrma-docs.phrma.org/files/dmfile/MID_Skin_Diseases_2018_9_FINAL.pdf DMJW0VS DI DMJW0VS DMJW0VS DN Tilidine DMJW0VS MI TTN4QDT DMJW0VS MN Opioid receptor (OPR) DMJW0VS MT DTT DMJW0VS MA Modulator DMJW0VS RN Actions of tilidine and nortilidine on cloned opioid receptors. Eur J Pharmacol. 2005 Jan 4;506(3):205-8. DMJW0VS RU https://pubmed.ncbi.nlm.nih.gov/15627429 DM3NXRU DI DM3NXRU DM3NXRU DN Timolol DM3NXRU MI TTR6W5O DM3NXRU MN Adrenergic receptor beta-1 (ADRB1) DM3NXRU MT DTT DM3NXRU MA Antagonist DM3NXRU RN Topical dorzolamide 2%/timolol 0.5% ophthalmic solution: a review of its use in the treatment of glaucoma and ocular hypertension. Drugs Aging. 2006;23(12):977-95. DM3NXRU RU https://pubmed.ncbi.nlm.nih.gov/17154662 DM3NXRU DI DM3NXRU DM3NXRU DN Timolol DM3NXRU MI DECB0K3 DM3NXRU MN Cytochrome P450 2D6 (CYP2D6) DM3NXRU MT DME DM3NXRU MA Metabolism DM3NXRU RN Cardiac safety of ophthalmic timolol. Expert Opin Drug Saf. 2016 Nov;15(11):1549-1561. DM3NXRU RU https://www.ncbi.nlm.nih.gov/pubmed/?term=27534869 DM3NXRU DI DM3NXRU DM3NXRU DN Timolol DM3NXRU MI DEGTFWK DM3NXRU MN Mephenytoin 4-hydroxylase (CYP2C19) DM3NXRU MT DME DM3NXRU MA Metabolism DM3NXRU RN Metabolism of ophthalmic timolol: new aspects of an old drug. Basic Clin Pharmacol Toxicol. 2011 May;108(5):297-303. DM3NXRU RU https://www.ncbi.nlm.nih.gov/pubmed/?term=21385322 DM3NXRU DI DM3NXRU DM3NXRU DN Timolol DM3NXRU MI DTUGYRD DM3NXRU MN P-glycoprotein 1 (ABCB1) DM3NXRU MT DTP DM3NXRU MA Substrate DM3NXRU RN Relationship between urinary sodium excretion and pioglitazone-induced edema. J Diabetes Investig. 2010 Oct 19;1(5):208-11. DM3NXRU RU https://doi.org/10.1111/j.2042-7158.1996.tb05904.x DM3OWT4 DI DM3OWT4 DM3OWT4 DN Tindamax DM3OWT4 MI DE4LYSA DM3OWT4 MN Cytochrome P450 3A4 (CYP3A4) DM3OWT4 MT DME DM3OWT4 MA Metabolism DM3OWT4 RN FDA label of Tinidazole. The 2020 official website of the U.S. Food and Drug Administration. DM3OWT4 RU https://www.accessdata.fda.gov/drugsatfda_docs/label/2007/021618s003lbl.pdf DM3OWT4 DI DM3OWT4 DM3OWT4 DN Tindamax DM3OWT4 MI DEAN5EW DM3OWT4 MN Nitroreductase (NTR) DM3OWT4 MT DME DM3OWT4 MA Metabolism DM3OWT4 RN Overexpression, isotopic labeling, and spectral characterization of Enterobacter cloacae nitroreductase. Protein Expr Purif. 1998 Jun;13(1):53-60. DM3OWT4 RU https://pubmed.ncbi.nlm.nih.gov/9631515 DMNYPGS DI DMNYPGS DMNYPGS DN Tioconazole DMNYPGS MI TTTSOUD DMNYPGS MN Candida Cytochrome P450 51 (Candi ERG11) DMNYPGS MT DTT DMNYPGS MA Inhibitor DMNYPGS RN Biological spectra analysis: Linking biological activity profiles to molecular structure. Proc Natl Acad Sci U S A. 2005 Jan 11;102(2):261-6. DMNYPGS RU https://pubmed.ncbi.nlm.nih.gov/15625110 DMFDC0Q DI DMFDC0Q DMFDC0Q DN Tiotropium DMFDC0Q MI TTOXS3C DMFDC0Q MN Muscarinic acetylcholine receptor (CHRM) DMFDC0Q MT DTT DMFDC0Q MA Antagonist DMFDC0Q RN Pharmacological characterization of GSK573719 (umeclidinium): a novel, long-acting, inhaled antagonist of the muscarinic cholinergic receptors for treatment of pulmonary diseases. J Pharmacol Exp Ther. 2013 May;345(2):260-70. DMFDC0Q RU https://pubmed.ncbi.nlm.nih.gov/23435542 DMFDC0Q DI DMFDC0Q DMFDC0Q DN Tiotropium DMFDC0Q MI TTQ13Z5 DMFDC0Q MN Muscarinic acetylcholine receptor M3 (CHRM3) DMFDC0Q MT DTT DMFDC0Q MA Antagonist DMFDC0Q RN DrugBank: a knowledgebase for drugs, drug actions and drug targets. Nucleic Acids Res. 2008 Jan;36(Database issue):D901-6. DMFDC0Q RU https://pubmed.ncbi.nlm.nih.gov/18048412 DMFDC0Q DI DMFDC0Q DMFDC0Q DN Tiotropium DMFDC0Q MI DTT79CX DMFDC0Q MN Organic cation transporter 1 (SLC22A1) DMFDC0Q MT DTP DMFDC0Q MA Substrate DMFDC0Q RN Identification of novel substrates and structure-activity relationship of cellular uptake mediated by human organic cation transporters 1 and 2. J Med Chem. 2013 Sep 26;56(18):7232-42. DMFDC0Q RU http://www.ncbi.nlm.nih.gov/pubmed/23984907 DMFDC0Q DI DMFDC0Q DMFDC0Q DN Tiotropium DMFDC0Q MI DT3HUVD DMFDC0Q MN Organic cation/carnitine transporter 2 (SLC22A5) DMFDC0Q MT DTP DMFDC0Q MA Substrate DMFDC0Q RN Transport of ipratropium, an anti-chronic obstructive pulmonary disease drug, is mediated by organic cation/carnitine transporters in human bronchial epithelial cells: implications for carrier-mediated pulmonary absorption. Mol Pharm. 2010 Feb 1;7(1):187-95. DMFDC0Q RU http://www.ncbi.nlm.nih.gov/pubmed/20020740 DM8HJX6 DI DM8HJX6 DM8HJX6 DN Tipranavir DM8HJX6 MI DECB0K3 DM8HJX6 MN Cytochrome P450 2D6 (CYP2D6) DM8HJX6 MT DME DM8HJX6 MA Metabolism DM8HJX6 RN A phenotype-genotype approach to predicting CYP450 and P-glycoprotein drug interactions with the mixed inhibitor/inducer tipranavir/ritonavir. Clin Pharmacol Ther. 2010 Jun;87(6):735-42. DM8HJX6 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=20147896 DM8HJX6 DI DM8HJX6 DM8HJX6 DN Tipranavir DM8HJX6 MI DE4LYSA DM8HJX6 MN Cytochrome P450 3A4 (CYP3A4) DM8HJX6 MT DME DM8HJX6 MA Metabolism DM8HJX6 RN A phenotype-genotype approach to predicting CYP450 and P-glycoprotein drug interactions with the mixed inhibitor/inducer tipranavir/ritonavir. Clin Pharmacol Ther. 2010 Jun;87(6):735-42. DM8HJX6 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=20147896 DM8HJX6 DI DM8HJX6 DM8HJX6 DN Tipranavir DM8HJX6 MI TT5FNQT DM8HJX6 MN Human immunodeficiency virus Protease (HIV PR) DM8HJX6 MT DTT DM8HJX6 MA Modulator DM8HJX6 RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. DM8HJX6 RU https://www.fda.gov/ DM8HJX6 DI DM8HJX6 DM8HJX6 DN Tipranavir DM8HJX6 MI DEGTFWK DM8HJX6 MN Mephenytoin 4-hydroxylase (CYP2C19) DM8HJX6 MT DME DM8HJX6 MA Metabolism DM8HJX6 RN A phenotype-genotype approach to predicting CYP450 and P-glycoprotein drug interactions with the mixed inhibitor/inducer tipranavir/ritonavir. Clin Pharmacol Ther. 2010 Jun;87(6):735-42. DM8HJX6 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=20147896 DMJNV4O DI DMJNV4O DMJNV4O DN Tirbanibulin DMJNV4O MI TTHVQ4N DMJNV4O MN Tubulin polymerization (TubP) DMJNV4O MT DTT DMJNV4O MA Inhibitor DMJNV4O RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health Human Services. 2020 DMJNV4O RU https://www.accessdata.fda.gov/drugsatfda_docs/label/2020/213189s000lbl.pdf DMQG17S DI DMQG17S DMQG17S DN Tirofiban DMQG17S MI TT38RM1 DMQG17S MN Glycoprotein IIb/IIIa receptor (GPIIb/IIIa) DMQG17S MT DTT DMQG17S MA Modulator DMQG17S RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. DMQG17S RU https://www.fda.gov/ DMM9BJD DI DMM9BJD DMM9BJD DN Tisagenlecleucel DMM9BJD MI TTW640A DMM9BJD MN B-lymphocyte surface antigen B4 (CD19) DMM9BJD MT DTT DMM9BJD MA Immunostimulant DMM9BJD RN 2017 FDA drug approvals.Nat Rev Drug Discov. 2018 Feb;17(2):81-85. DMM9BJD RU https://pubmed.ncbi.nlm.nih.gov/29348678 DMM9BJD DI DMM9BJD DMM9BJD DN Tisagenlecleucel DMM9BJD MI TTUE541 DMM9BJD MN Leukocyte surface antigen Leu-16 (CD20) DMM9BJD MT DTT DMM9BJD MA Immunostimulant DMM9BJD RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMM9BJD RU http://phrma-docs.phrma.org/files/dmfile/MID_Immuno-Oncology-2017_Drug-List1.pdf DMGVUO5 DI DMGVUO5 DMGVUO5 DN Tislelizumab DMGVUO5 MI TTNBFWK DMGVUO5 MN Programmed cell death protein 1 (PD-1) DMGVUO5 MT DTT DMGVUO5 RN Tislelizumab: an investigational anti-PD-1 antibody for the treatment of advanced non-small cell lung cancer (NSCLC). Expert Opin Investig Drugs. 2020 Dec;29(12):1355-1364. DMGVUO5 RU https://pubmed.ncbi.nlm.nih.gov/33044117 DMUKC5L DI DMUKC5L DMUKC5L DN Tivozanib DMUKC5L MI TT2Q6G1 DMUKC5L MN Vascular endothelial growth factor receptor 1 (FLT-1) DMUKC5L MT DTT DMUKC5L MA Inhibitor DMUKC5L RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health Human Services DMUKC5L RU https://www.fda.gov/drugs/drug-approvals-and-databases/fda-approves-tivozanib-relapsed-or-refractory-advanced-renal-cell-carcinoma DMUKC5L DI DMUKC5L DMUKC5L DN Tivozanib DMUKC5L MI TTUTJGQ DMUKC5L MN Vascular endothelial growth factor receptor 2 (KDR) DMUKC5L MT DTT DMUKC5L MA Modulator DMUKC5L RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health Human Services DMUKC5L RU https://www.fda.gov/drugs/drug-approvals-and-databases/fda-approves-tivozanib-relapsed-or-refractory-advanced-renal-cell-carcinoma DMUKC5L DI DMUKC5L DMUKC5L DN Tivozanib DMUKC5L MI TTDCBX5 DMUKC5L MN Vascular endothelial growth factor receptor 3 (FLT-4) DMUKC5L MT DTT DMUKC5L MA Modulator DMUKC5L RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health Human Services DMUKC5L RU https://www.fda.gov/drugs/drug-approvals-and-databases/fda-approves-tivozanib-relapsed-or-refractory-advanced-renal-cell-carcinoma DMR2IQ4 DI DMR2IQ4 DMR2IQ4 DN Tizanidine DMR2IQ4 MI TTQ8AFT DMR2IQ4 MN Adrenergic receptor Alpha-2 (ADRA2) DMR2IQ4 MT DTT DMR2IQ4 MA Agonist DMR2IQ4 RN Tizanidine. A review of its pharmacology, clinical efficacy and tolerability in the management of spasticity associated with cerebral and spinal disorders. Drugs. 1997 Mar;53(3):435-52. DMR2IQ4 RU https://pubmed.ncbi.nlm.nih.gov/9074844 DMR2IQ4 DI DMR2IQ4 DMR2IQ4 DN Tizanidine DMR2IQ4 MI DEJGDUW DMR2IQ4 MN Cytochrome P450 1A2 (CYP1A2) DMR2IQ4 MT DME DMR2IQ4 MA Metabolism DMR2IQ4 RN Synthetic and natural compounds that interact with human cytochrome P450 1A2 and implications in drug development. Curr Med Chem. 2009;16(31):4066-218. DMR2IQ4 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=19754423 DMUI0CH DI DMUI0CH DMUI0CH DN Tobramycin DMUI0CH MI DEJADS9 DMUI0CH MN Aminoglycoside N-acetyltransferase (aacC2) DMUI0CH MT DME DMUI0CH MA Metabolism DMUI0CH RN Relationship between antimicrobial resistance and aminoglycoside-modifying enzyme gene expressions in Acinetobacter baumannii. Chin Med J (Engl). 2005 Jan 20;118(2):141-5. DMUI0CH RU https://pubmed.ncbi.nlm.nih.gov/15667800 DMUI0CH DI DMUI0CH DMUI0CH DN Tobramycin DMUI0CH MI DEWPAJD DMUI0CH MN Aminoglycoside O-phosphotransferase (aphA6) DMUI0CH MT DME DMUI0CH MA Metabolism DMUI0CH RN Relationship between antimicrobial resistance and aminoglycoside-modifying enzyme gene expressions in Acinetobacter baumannii. Chin Med J (Engl). 2005 Jan 20;118(2):141-5. DMUI0CH RU https://pubmed.ncbi.nlm.nih.gov/15667800 DMUI0CH DI DMUI0CH DMUI0CH DN Tobramycin DMUI0CH MI DE5WGIM DMUI0CH MN Aminoglycoside phosphotransferase (aph-Ib) DMUI0CH MT DME DMUI0CH MA Metabolism DMUI0CH RN Cloning and expression of novel aminoglycoside phosphotransferase genes from Campylobacter and their role in the resistance to six aminoglycosides. Antimicrob Agents Chemother. 2017 Dec 21;62(1). pii: e01682-17. DMUI0CH RU https://pubmed.ncbi.nlm.nih.gov/29109167 DMUI0CH DI DMUI0CH DMUI0CH DN Tobramycin DMUI0CH MI TTOVFH2 DMUI0CH MN Bacterial 30S ribosomal RNA (Bact 30S rRNA) DMUI0CH MT DTT DMUI0CH MA Modulator DMUI0CH RN Mechanism of action of aminoglycoside antibiotics.Binding studies of tobramycin and its 6'-N-acetyl derivative to the bacterial ribosome and its subunits.Eur J Biochem.1979 Dec;102(1):73-81. DMUI0CH RU https://www.ncbi.nlm.nih.gov/pubmed/391568 DMUI0CH DI DMUI0CH DMUI0CH DN Tobramycin DMUI0CH MI DECXWN8 DMUI0CH MN Kanamycin/gentamycin-resistance enzyme (aacA) DMUI0CH MT DME DMUI0CH MA Metabolism DMUI0CH RN Cloning and expression of novel aminoglycoside phosphotransferase genes from Campylobacter and their role in the resistance to six aminoglycosides. Antimicrob Agents Chemother. 2017 Dec 21;62(1). pii: e01682-17. DMUI0CH RU https://pubmed.ncbi.nlm.nih.gov/29109167 DMUI0CH DI DMUI0CH DMUI0CH DN Tobramycin DMUI0CH MI DEZV4AP DMUI0CH MN RNA cytidine acetyltransferase (hALP) DMUI0CH MT DME DMUI0CH MA Metabolism DMUI0CH RN Genetic analysis of bacterial acetyltransferases: identification of amino acids determining the specificities of the aminoglycoside 6'-N-acetyltransferase Ib and IIa proteins. J Bacteriol. 1992 May;174(10):3196-203. DMUI0CH RU https://www.ncbi.nlm.nih.gov/pubmed/?term=1577689 DMYNMDP DI DMYNMDP DMYNMDP DN Tocainide DMYNMDP MI DEJGDUW DMYNMDP MN Cytochrome P450 1A2 (CYP1A2) DMYNMDP MT DME DMYNMDP MA Metabolism DMYNMDP RN The effect of tocainide on theophylline metabolism. Br J Clin Pharmacol. 1993 Apr;35(4):437-40. DMYNMDP RU https://www.ncbi.nlm.nih.gov/pubmed/?term=8485025 DMYNMDP DI DMYNMDP DMYNMDP DN Tocainide DMYNMDP MI TT05DLS DMYNMDP MN E3 ubiquitin-protein ligase COP1 (RFWD2) DMYNMDP MT DTT DMYNMDP MA Modulator DMYNMDP RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. DMYNMDP RU https://www.fda.gov/ DM7J6OR DI DM7J6OR DM7J6OR DN Tocilizumab DM7J6OR MI TT0E5SK DM7J6OR MN Interleukin 6 receptor (IL6R) DM7J6OR MT DTT DM7J6OR MA Modulator DM7J6OR RN Mullard A: 2010 FDA drug approvals. Nat Rev Drug Discov. 2011 Feb;10(2):82-5. DM7J6OR RU https://pubmed.ncbi.nlm.nih.gov/21283092 DM1UE67 DI DM1UE67 DM1UE67 DN TOCOTRIENOL DM1UE67 MI TTPADOQ DM1UE67 MN HMG-CoA reductase (HMGCR) DM1UE67 MT DTT DM1UE67 MA Inhibitor DM1UE67 RN Inhibitory effect of delta-tocotrienol, a HMG CoA reductase inhibitor, on monocyte-endothelial cell adhesion. J Nutr Sci Vitaminol (Tokyo). 2002 Oct;48(5):332-7. DM1UE67 RU https://pubmed.ncbi.nlm.nih.gov/12656204 DMBS370 DI DMBS370 DMBS370 DN Tofacitinib DMBS370 MI DE4LYSA DMBS370 MN Cytochrome P450 3A4 (CYP3A4) DMBS370 MT DME DMBS370 MA Metabolism DMBS370 RN The pharmacokinetics, metabolism, and clearance mechanisms of tofacitinib, a janus kinase inhibitor, in humans. Drug Metab Dispos. 2014 Apr;42(4):759-73. DMBS370 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=24464803 DMBS370 DI DMBS370 DMBS370 DN Tofacitinib DMBS370 MI TTT7PJU DMBS370 MN Janus kinase 3 (JAK-3) DMBS370 MT DTT DMBS370 MA Modulator DMBS370 RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015 DMBS370 RU https://www.accessdata.fda.gov/scripts/cder/drugsatfda/ DMBS370 DI DMBS370 DMBS370 DN Tofacitinib DMBS370 MI DEGTFWK DMBS370 MN Mephenytoin 4-hydroxylase (CYP2C19) DMBS370 MT DME DMBS370 MA Metabolism DMBS370 RN The pharmacokinetics, metabolism, and clearance mechanisms of tofacitinib, a janus kinase inhibitor, in humans. Drug Metab Dispos. 2014 Apr;42(4):759-73. DMBS370 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=24464803 DMIHRNA DI DMIHRNA DMIHRNA DN Tolazamide DMIHRNA MI DE5IED8 DMIHRNA MN Cytochrome P450 2C9 (CYP2C9) DMIHRNA MT DME DMIHRNA MA Metabolism DMIHRNA RN Clinically and pharmacologically relevant interactions of antidiabetic drugs. Ther Adv Endocrinol Metab. 2016 Apr;7(2):69-83. DMIHRNA RU https://www.ncbi.nlm.nih.gov/pubmed/?term=27092232 DMIHRNA DI DMIHRNA DMIHRNA DN Tolazamide DMIHRNA MI TTG140O DMIHRNA MN Inward rectifier potassium channel Kir1.2 (KCNJ10) DMIHRNA MT DTT DMIHRNA MA Blocker DMIHRNA RN Inhibition of ATP-activated potassium channels exerts pressor effects and improves survival in a rat model of severe hemorrhagic shock. Shock. 1996 Jun;5(6):391-4. DMIHRNA RU https://pubmed.ncbi.nlm.nih.gov/8799949 DMI40NL DI DMI40NL DMI40NL DN Tolazoline DMI40NL MI TTEX248 DMI40NL MN Dopamine D2 receptor (D2R) DMI40NL MT DTT DMI40NL MA Antagonist DMI40NL RN Comparative effects of tolazoline and nitroprusside on human isolated radial artery. Ann Thorac Surg. 2006 Jan;81(1):125-31. DMI40NL RU https://pubmed.ncbi.nlm.nih.gov/16368348 DM02AWV DI DM02AWV DM02AWV DN Tolbutamide DM02AWV MI TTP835K DM02AWV MN ATP-binding cassette transporter C8 (ABCC8) DM02AWV MT DTT DM02AWV MA Blocker DM02AWV RN Expression of an activating mutation in the gene encoding the KATP channel subunit Kir6.2 in mouse pancreatic beta cells recapitulates neonatal diabetes. J Clin Invest. 2009 Jan;119(1):80-90. DM02AWV RU https://pubmed.ncbi.nlm.nih.gov/19065048 DM02AWV DI DM02AWV DM02AWV DN Tolbutamide DM02AWV MI TTEF5MJ DM02AWV MN ATP-binding cassette transporter C9 (ABCC9) DM02AWV MT DTT DM02AWV MA Blocker DM02AWV RN Expression of an activating mutation in the gene encoding the KATP channel subunit Kir6.2 in mouse pancreatic beta cells recapitulates neonatal diabetes. J Clin Invest. 2009 Jan;119(1):80-90. DM02AWV RU https://pubmed.ncbi.nlm.nih.gov/19065048 DM02AWV DI DM02AWV DM02AWV DN Tolbutamide DM02AWV MI DEZMWRE DM02AWV MN Cytochrome P450 2C18 (CYP2C18) DM02AWV MT DME DM02AWV MA Metabolism DM02AWV RN Summary of information on human CYP enzymes: human P450 metabolism data. Drug Metab Rev. 2002 Feb-May;34(1-2):83-448. DM02AWV RU https://www.ncbi.nlm.nih.gov/pubmed/?term=11996015 DM02AWV DI DM02AWV DM02AWV DN Tolbutamide DM02AWV MI DES5XRU DM02AWV MN Cytochrome P450 2C8 (CYP2C8) DM02AWV MT DME DM02AWV MA Metabolism DM02AWV RN Prediction of in vivo drug-drug interactions between tolbutamide and various sulfonamides in humans based on in vitro experiments. Drug Metab Dispos. 2000 Apr;28(4):475-81. DM02AWV RU https://www.ncbi.nlm.nih.gov/pubmed/?term=10725317 DM02AWV DI DM02AWV DM02AWV DN Tolbutamide DM02AWV MI DE5IED8 DM02AWV MN Cytochrome P450 2C9 (CYP2C9) DM02AWV MT DME DM02AWV MA Metabolism DM02AWV RN Effects of organic solvents on the activities of cytochrome P450 isoforms, UDP-dependent glucuronyl transferase, and phenol sulfotransferase in human hepatocytes. Drug Metab Dispos. 2001 Feb;29(2):141-4. DM02AWV RU https://www.ncbi.nlm.nih.gov/pubmed/?term=11159803 DM02AWV DI DM02AWV DM02AWV DN Tolbutamide DM02AWV MI DEGTFWK DM02AWV MN Mephenytoin 4-hydroxylase (CYP2C19) DM02AWV MT DME DM02AWV MA Metabolism DM02AWV RN CYP2C19 participates in tolbutamide hydroxylation by human liver microsomes. Drug Metab Dispos. 2000 Mar;28(3):354-9. DM02AWV RU https://www.ncbi.nlm.nih.gov/pubmed/?term=10681382 DM02AWV DI DM02AWV DM02AWV DN Tolbutamide DM02AWV MI DTI58LU DM02AWV MN Sulfonylurea receptor 1 (ABCC8) DM02AWV MT DTP DM02AWV MA Substrate DM02AWV RN ABCC8 and ABCC9: ABC transporters that regulate K+ channels. Pflugers Arch. 2007 Feb;453(5):703-18. DM02AWV RU http://www.ncbi.nlm.nih.gov/pubmed/16897043 DM02AWV DI DM02AWV DM02AWV DN Tolbutamide DM02AWV MI DT3JCE6 DM02AWV MN Sulfonylurea receptor 2 (ABCC9) DM02AWV MT DTP DM02AWV MA Substrate DM02AWV RN ABCC8 and ABCC9: ABC transporters that regulate K+ channels. Pflugers Arch. 2007 Feb;453(5):703-18. DM02AWV RU http://www.ncbi.nlm.nih.gov/pubmed/16897043 DM8MNVO DI DM8MNVO DM8MNVO DN Tolcapone DM8MNVO MI TTKWFB8 DM8MNVO MN Catechol-O-methyl-transferase (COMT) DM8MNVO MT DTT DM8MNVO MA Inhibitor DM8MNVO RN Catechol-O-methyltransferase inhibitors in the management of Parkinson's disease. Semin Neurol. 2001;21(1):15-22. DM8MNVO RU https://pubmed.ncbi.nlm.nih.gov/11346021 DMWUIJE DI DMWUIJE DMWUIJE DN Tolmetin DMWUIJE MI TTVKILB DMWUIJE MN Prostaglandin G/H synthase 2 (COX-2) DMWUIJE MT DTT DMWUIJE MA Inhibitor DMWUIJE RN Maternal toxicity of nonsteroidal anti-inflammatory drugs as an important factor affecting prenatal development. Reprod Toxicol. 2009 Sep;28(2):239-44. DMWUIJE RU https://pubmed.ncbi.nlm.nih.gov/19379806 DM28MU7 DI DM28MU7 DM28MU7 DN Tolnaftate DM28MU7 MI TTE14XG DM28MU7 MN Squalene monooxygenase (SQLE) DM28MU7 MT DTT DM28MU7 MA Inhibitor DM28MU7 RN Effects of squalene epoxidase inhibitors on Candida albicans. Antimicrob Agents Chemother. 1992 Aug;36(8):1779-81. DM28MU7 RU https://pubmed.ncbi.nlm.nih.gov/1416865 DMA2GHJ DI DMA2GHJ DMA2GHJ DN Tolperisone DMA2GHJ MI DEJGDUW DMA2GHJ MN Cytochrome P450 1A2 (CYP1A2) DMA2GHJ MT DME DMA2GHJ MA Metabolism DMA2GHJ RN Identification of metabolic pathways involved in the biotransformation of tolperisone by human microsomal enzymes. Drug Metab Dispos. 2003 May;31(5):631-6. DMA2GHJ RU https://www.ncbi.nlm.nih.gov/pubmed/?term=12695352 DMA2GHJ DI DMA2GHJ DMA2GHJ DN Tolperisone DMA2GHJ MI DECB0K3 DMA2GHJ MN Cytochrome P450 2D6 (CYP2D6) DMA2GHJ MT DME DMA2GHJ MA Metabolism DMA2GHJ RN Identification of metabolic pathways involved in the biotransformation of tolperisone by human microsomal enzymes. Drug Metab Dispos. 2003 May;31(5):631-6. DMA2GHJ RU https://www.ncbi.nlm.nih.gov/pubmed/?term=12695352 DMA2GHJ DI DMA2GHJ DMA2GHJ DN Tolperisone DMA2GHJ MI DEGTFWK DMA2GHJ MN Mephenytoin 4-hydroxylase (CYP2C19) DMA2GHJ MT DME DMA2GHJ MA Metabolism DMA2GHJ RN Identification of metabolic pathways involved in the biotransformation of tolperisone by human microsomal enzymes. Drug Metab Dispos. 2003 May;31(5):631-6. DMA2GHJ RU https://www.ncbi.nlm.nih.gov/pubmed/?term=12695352 DMA2GHJ DI DMA2GHJ DMA2GHJ DN Tolperisone DMA2GHJ MI TTCRJKY DMA2GHJ MN Voltage-gated calcium channel (Cav) DMA2GHJ MT DTT DMA2GHJ MA Modulator DMA2GHJ RN Tolperisone-type drugs inhibit spinal reflexes via blockade of voltage-gated sodium and calcium channels. J Pharmacol Exp Ther. 2005 Dec;315(3):1237-46. DMA2GHJ RU https://pubmed.ncbi.nlm.nih.gov/16126840 DMA2GHJ DI DMA2GHJ DMA2GHJ DN Tolperisone DMA2GHJ MI TTN9VTF DMA2GHJ MN Voltage-gated sodium channel alpha Nav1.9 (SCN11A) DMA2GHJ MT DTT DMA2GHJ MA Modulator DMA2GHJ RN Tolperisone-type drugs inhibit spinal reflexes via blockade of voltage-gated sodium and calcium channels. J Pharmacol Exp Ther. 2005 Dec;315(3):1237-46. DMA2GHJ RU https://pubmed.ncbi.nlm.nih.gov/16126840 DMSHPW8 DI DMSHPW8 DMSHPW8 DN Tolterodine DMSHPW8 MI DE5IED8 DMSHPW8 MN Cytochrome P450 2C9 (CYP2C9) DMSHPW8 MT DME DMSHPW8 MA Metabolism DMSHPW8 RN Tolterodine, a new muscarinic receptor antagonist, is metabolized by cytochromes P450 2D6 and 3A in human liver microsomes. Drug Metab Dispos. 1998 Apr;26(4):289-93. DMSHPW8 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=9531513 DMSHPW8 DI DMSHPW8 DMSHPW8 DN Tolterodine DMSHPW8 MI DECB0K3 DMSHPW8 MN Cytochrome P450 2D6 (CYP2D6) DMSHPW8 MT DME DMSHPW8 MA Metabolism DMSHPW8 RN Effect of the CYP2D6*10 genotype on tolterodine pharmacokinetics. Drug Metab Dispos. 2010 Sep;38(9):1456-63. DMSHPW8 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=20530222 DMSHPW8 DI DMSHPW8 DMSHPW8 DN Tolterodine DMSHPW8 MI DE4LYSA DMSHPW8 MN Cytochrome P450 3A4 (CYP3A4) DMSHPW8 MT DME DMSHPW8 MA Metabolism DMSHPW8 RN Tolterodine, a new muscarinic receptor antagonist, is metabolized by cytochromes P450 2D6 and 3A in human liver microsomes. Drug Metab Dispos. 1998 Apr;26(4):289-93. DMSHPW8 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=9531513 DMSHPW8 DI DMSHPW8 DMSHPW8 DN Tolterodine DMSHPW8 MI DEGTFWK DMSHPW8 MN Mephenytoin 4-hydroxylase (CYP2C19) DMSHPW8 MT DME DMSHPW8 MA Metabolism DMSHPW8 RN Tolterodine, a new muscarinic receptor antagonist, is metabolized by cytochromes P450 2D6 and 3A in human liver microsomes. Drug Metab Dispos. 1998 Apr;26(4):289-93. DMSHPW8 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=9531513 DMSHPW8 DI DMSHPW8 DMSHPW8 DN Tolterodine DMSHPW8 MI TTQ13Z5 DMSHPW8 MN Muscarinic acetylcholine receptor M3 (CHRM3) DMSHPW8 MT DTT DMSHPW8 MA Antagonist DMSHPW8 RN Signal transduction underlying carbachol-induced contraction of human urinary bladder. J Pharmacol Exp Ther. 2004 Jun;309(3):1148-53. DMSHPW8 RU https://pubmed.ncbi.nlm.nih.gov/14769832 DMIWFRL DI DMIWFRL DMIWFRL DN Tolvaptan DMIWFRL MI DE4LYSA DMIWFRL MN Cytochrome P450 3A4 (CYP3A4) DMIWFRL MT DME DMIWFRL MA Metabolism DMIWFRL RN Tolvaptan: a new therapeutic agent. Rev Recent Clin Trials. 2011 May;6(2):177-88. DMIWFRL RU https://www.ncbi.nlm.nih.gov/pubmed/?term=20868352 DMIWFRL DI DMIWFRL DMIWFRL DN Tolvaptan DMIWFRL MI DTUGYRD DMIWFRL MN P-glycoprotein 1 (ABCB1) DMIWFRL MT DTP DMIWFRL MA Substrate DMIWFRL RN In vitro P-glycoprotein interactions and steady-state pharmacokinetic interactions between tolvaptan and digoxin in healthy subjects. 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DMAE6LK RU http://www.gsk.com/investors/product_pipeline/docs/gsk-pipeline-feb09.pdf DM82Z30 DI DM82Z30 DM82Z30 DN Topiramate DM82Z30 MI DE4LYSA DM82Z30 MN Cytochrome P450 3A4 (CYP3A4) DM82Z30 MT DME DM82Z30 MA Metabolism DM82Z30 RN Dose-dependent induction of cytochrome P450 (CYP) 3A4 and activation of pregnane X receptor by topiramate. Epilepsia. 2003 Dec;44(12):1521-8. DM82Z30 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=14636322 DM82Z30 DI DM82Z30 DM82Z30 DN Topiramate DM82Z30 MI TT0MYE2 DM82Z30 MN Glutamate receptor ionotropic kainate 1 (GRIK1) DM82Z30 MT DTT DM82Z30 MA Antagonist DM82Z30 RN Development of medications for alcohol use disorders: recent advances and ongoing challenges. Expert Opin Emerg Drugs. 2005 May;10(2):323-43. DM82Z30 RU https://pubmed.ncbi.nlm.nih.gov/15934870 DM82Z30 DI DM82Z30 DM82Z30 DN Topiramate DM82Z30 MI DTUGYRD DM82Z30 MN P-glycoprotein 1 (ABCB1) DM82Z30 MT DTP DM82Z30 MA Substrate DM82Z30 RN The antiepileptic drug topiramate is a substrate for human P-glycoprotein but not multidrug resistance proteins. Pharm Res. 2009 Nov;26(11):2464-70. DM82Z30 RU https://doi.org/10.1007/s11095-009-9961-8 DMP6G8T DI DMP6G8T DMP6G8T DN Topotecan DMP6G8T MI DTI7UX6 DMP6G8T MN Breast cancer resistance protein (ABCG2) DMP6G8T MT DTP DMP6G8T MA Substrate DMP6G8T RN Differential inhibition of murine Bcrp1/Abcg2 and human BCRP/ABCG2 by the mycotoxin fumitremorgin C. Eur J Pharmacol. 2010 Oct 10;644(1-3):41-8. DMP6G8T RU http://www.ncbi.nlm.nih.gov/pubmed/20655304 DMP6G8T DI DMP6G8T DMP6G8T DN Topotecan DMP6G8T MI TTGTQHC DMP6G8T MN DNA topoisomerase I (TOP1) DMP6G8T MT DTT DMP6G8T MA Modulator DMP6G8T RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. DMP6G8T RU https://www.fda.gov/ DMP6G8T DI DMP6G8T DMP6G8T DN Topotecan DMP6G8T MI DTZGT0P DMP6G8T MN Multidrug and toxin extrusion protein 1 (SLC47A1) DMP6G8T MT DTP DMP6G8T MA Substrate DMP6G8T RN Substrate specificity of MATE1 and MATE2-K, human multidrug and toxin extrusions/H(+)-organic cation antiporters. Biochem Pharmacol. 2007 Jul 15;74(2):359-71. DMP6G8T RU http://www.ncbi.nlm.nih.gov/pubmed/17509534 DMP6G8T DI DMP6G8T DMP6G8T DN Topotecan DMP6G8T MI DT3TX4H DMP6G8T MN Multidrug and toxin extrusion protein 2 (SLC47A2) DMP6G8T MT DTP DMP6G8T MA Substrate DMP6G8T RN Substrate specificity of MATE1 and MATE2-K, human multidrug and toxin extrusions/H(+)-organic cation antiporters. Biochem Pharmacol. 2007 Jul 15;74(2):359-71. DMP6G8T RU http://www.ncbi.nlm.nih.gov/pubmed/17509534 DMP6G8T DI DMP6G8T DMP6G8T DN Topotecan DMP6G8T MI DTSYQGK DMP6G8T MN Multidrug resistance-associated protein 1 (ABCC1) DMP6G8T MT DTP DMP6G8T MA Substrate DMP6G8T RN Human intestinal transporter database: QSAR modeling and virtual profiling of drug uptake, efflux and interactions. Pharm Res. 2013 Apr;30(4):996-1007. DMP6G8T RU https://doi.org/10.1007/s11095-012-0935-x DMP6G8T DI DMP6G8T DMP6G8T DN Topotecan DMP6G8T MI DTCSGPB DMP6G8T MN Multidrug resistance-associated protein 4 (ABCC4) DMP6G8T MT DTP DMP6G8T MA Substrate DMP6G8T RN Topotecan is a substrate for multidrug resistance associated protein 4. Curr Drug Metab. 2006 Jan;7(1):105-18. 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DMGB5RE RU https://pubmed.ncbi.nlm.nih.gov/16927039 DMZQOUX DI DMZQOUX DMZQOUX DN Trastuzumab DMZQOUX MI TT6EO5L DMZQOUX MN Erbb2 tyrosine kinase receptor (HER2) DMZQOUX MT DTT DMZQOUX RN Her2/neu is not a commonly expressed therapeutic target in melanoma -- a large cohort tissue microarray study. Melanoma Res. 2004 Jun;14(3):207-10. DMZQOUX RU https://pubmed.ncbi.nlm.nih.gov/15179190 DM20K91 DI DM20K91 DM20K91 DN Travoprost DM20K91 MI TTT2ZAR DM20K91 MN Prostaglandin F2-alpha receptor (PTGFR) DM20K91 MT DTT DM20K91 MA Agonist DM20K91 RN Prostaglandin subtype-selective and non-selective IOP-lowering comparison in monkeys. J Ocul Pharmacol Ther. 2009 Feb;25(1):1-8. DM20K91 RU https://pubmed.ncbi.nlm.nih.gov/19232013 DMK1GBJ DI DMK1GBJ DMK1GBJ DN Trazodone DMK1GBJ MI TTSQIFT DMK1GBJ MN 5-HT 1A receptor (HTR1A) DMK1GBJ MT DTT DMK1GBJ MA Modulator DMK1GBJ RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. DMK1GBJ RU https://www.fda.gov/ DMK1GBJ DI DMK1GBJ DMK1GBJ DN Trazodone DMK1GBJ MI DECB0K3 DMK1GBJ MN Cytochrome P450 2D6 (CYP2D6) DMK1GBJ MT DME DMK1GBJ MA Metabolism DMK1GBJ RN Evaluating the role of drug metabolism and reactive intermediates in trazodone-induced cytotoxicity toward freshly-isolated rat hepatocytes. Drug Res (Stuttg). 2016 Nov;66(11):592-596. DMK1GBJ RU https://www.ncbi.nlm.nih.gov/pubmed/?term=27643409 DMK1GBJ DI DMK1GBJ DMK1GBJ DN Trazodone DMK1GBJ MI DE4LYSA DMK1GBJ MN Cytochrome P450 3A4 (CYP3A4) DMK1GBJ MT DME DMK1GBJ MA Metabolism DMK1GBJ RN Metabolic activation of the nontricyclic antidepressant trazodone to electrophilic quinone-imine and epoxide intermediates in human liver microsomes and recombinant P4503A4. Chem Biol Interact. 2005 Jun 30;155(1-2):10-20. DMK1GBJ RU https://www.ncbi.nlm.nih.gov/pubmed/?term=15978881 DMK1GBJ DI DMK1GBJ DMK1GBJ DN Trazodone DMK1GBJ MI DEIBDNY DMK1GBJ MN Cytochrome P450 3A5 (CYP3A5) DMK1GBJ MT DME DMK1GBJ MA Metabolism DMK1GBJ RN Drug Interactions Flockhart Table DMK1GBJ RU https://drug-interactions.medicine.iu.edu/Main-Table.aspx DMK1GBJ DI DMK1GBJ DMK1GBJ DN Trazodone DMK1GBJ MI DERD86B DMK1GBJ MN Cytochrome P450 3A7 (CYP3A7) DMK1GBJ MT DME DMK1GBJ MA Metabolism DMK1GBJ RN Drug Interactions Flockhart Table DMK1GBJ RU https://drug-interactions.medicine.iu.edu/Main-Table.aspx DMK1GBJ DI DMK1GBJ DMK1GBJ DN Trazodone DMK1GBJ MI TT3ROYC DMK1GBJ MN Serotonin transporter (SERT) DMK1GBJ MT DTT DMK1GBJ MA Modulator DMK1GBJ RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. DMK1GBJ RU https://www.fda.gov/ DMTIQF3 DI DMTIQF3 DMTIQF3 DN Treprostinil DMTIQF3 MI DES5XRU DMTIQF3 MN Cytochrome P450 2C8 (CYP2C8) DMTIQF3 MT DME DMTIQF3 MA Metabolism DMTIQF3 RN FDA label of Treprostinil. The 2020 official website of the U.S. Food and Drug Administration. DMTIQF3 RU https://www.accessdata.fda.gov/drugsatfda_docs/label/2018/021272s026lbl.pdf DMTIQF3 DI DMTIQF3 DMTIQF3 DN Treprostinil DMTIQF3 MI DE5IED8 DMTIQF3 MN Cytochrome P450 2C9 (CYP2C9) DMTIQF3 MT DME DMTIQF3 MA Metabolism DMTIQF3 RN Lack of a pharmacokinetic interaction between oral treprostinil and bosentan in healthy adult volunteers. J Clin Pharmacol. 2010 Jul;50(7):829-34. DMTIQF3 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=20133511 DMTIQF3 DI DMTIQF3 DMTIQF3 DN Treprostinil DMTIQF3 MI TTOFYT1 DMTIQF3 MN Prostacyclin receptor (PTGIR) DMTIQF3 MT DTT DMTIQF3 MA Agonist DMTIQF3 RN Dosing considerations in the use of intravenous prostanoids in pulmonary arterial hypertension: an experience-based review. Am Heart J. 2009 Apr;157(4):625-35. DMTIQF3 RU https://pubmed.ncbi.nlm.nih.gov/19332188 DM49DUI DI DM49DUI DM49DUI DN Tretinoin DM49DUI MI DEXNDR0 DM49DUI MN Cytochrome P450 26C1 (CYP26C1) DM49DUI MT DME DM49DUI MA Metabolism DM49DUI RN CYP26C1 is a hydroxylase of multiple active retinoids and interacts with cellular retinoic acid binding proteins. Mol Pharmacol. 2018 May;93(5):489-503. DM49DUI RU https://pubmed.ncbi.nlm.nih.gov/29476041 DM49DUI DI DM49DUI DM49DUI DN Tretinoin DM49DUI MI DEJVYAZ DM49DUI MN Cytochrome P450 2A6 (CYP2A6) DM49DUI MT DME DM49DUI MA Metabolism DM49DUI RN Summary of information on human CYP enzymes: human P450 metabolism data. Drug Metab Rev. 2002 Feb-May;34(1-2):83-448. DM49DUI RU https://www.ncbi.nlm.nih.gov/pubmed/?term=11996015 DM49DUI DI DM49DUI DM49DUI DN Tretinoin DM49DUI MI DEPKLMQ DM49DUI MN Cytochrome P450 2B6 (CYP2B6) DM49DUI MT DME DM49DUI MA Metabolism DM49DUI RN Summary of information on human CYP enzymes: human P450 metabolism data. Drug Metab Rev. 2002 Feb-May;34(1-2):83-448. DM49DUI RU https://www.ncbi.nlm.nih.gov/pubmed/?term=11996015 DM49DUI DI DM49DUI DM49DUI DN Tretinoin DM49DUI MI DEZMWRE DM49DUI MN Cytochrome P450 2C18 (CYP2C18) DM49DUI MT DME DM49DUI MA Metabolism DM49DUI RN Identification of human cytochrome P450s involved in the formation of all-trans-retinoic acid principal metabolites. Mol Pharmacol. 2000 Dec;58(6):1341-8. DM49DUI RU https://www.ncbi.nlm.nih.gov/pubmed/?term=11093772 DM49DUI DI DM49DUI DM49DUI DN Tretinoin DM49DUI MI DES5XRU DM49DUI MN Cytochrome P450 2C8 (CYP2C8) DM49DUI MT DME DM49DUI MA Metabolism DM49DUI RN Identification of human cytochrome P450s involved in the formation of all-trans-retinoic acid principal metabolites. Mol Pharmacol. 2000 Dec;58(6):1341-8. DM49DUI RU https://www.ncbi.nlm.nih.gov/pubmed/?term=11093772 DM49DUI DI DM49DUI DM49DUI DN Tretinoin DM49DUI MI DE5IED8 DM49DUI MN Cytochrome P450 2C9 (CYP2C9) DM49DUI MT DME DM49DUI MA Metabolism DM49DUI RN Summary of information on human CYP enzymes: human P450 metabolism data. Drug Metab Rev. 2002 Feb-May;34(1-2):83-448. DM49DUI RU https://www.ncbi.nlm.nih.gov/pubmed/?term=11996015 DM49DUI DI DM49DUI DM49DUI DN Tretinoin DM49DUI MI DE4LYSA DM49DUI MN Cytochrome P450 3A4 (CYP3A4) DM49DUI MT DME DM49DUI MA Metabolism DM49DUI RN Identification of human cytochrome P450s involved in the formation of all-trans-retinoic acid principal metabolites. Mol Pharmacol. 2000 Dec;58(6):1341-8. DM49DUI RU https://www.ncbi.nlm.nih.gov/pubmed/?term=11093772 DM49DUI DI DM49DUI DM49DUI DN Tretinoin DM49DUI MI DEIBDNY DM49DUI MN Cytochrome P450 3A5 (CYP3A5) DM49DUI MT DME DM49DUI MA Metabolism DM49DUI RN Identification of human cytochrome P450s involved in the formation of all-trans-retinoic acid principal metabolites. Mol Pharmacol. 2000 Dec;58(6):1341-8. DM49DUI RU https://www.ncbi.nlm.nih.gov/pubmed/?term=11093772 DM49DUI DI DM49DUI DM49DUI DN Tretinoin DM49DUI MI DERD86B DM49DUI MN Cytochrome P450 3A7 (CYP3A7) DM49DUI MT DME DM49DUI MA Metabolism DM49DUI RN Identification of human cytochrome P450s involved in the formation of all-trans-retinoic acid principal metabolites. Mol Pharmacol. 2000 Dec;58(6):1341-8. DM49DUI RU https://www.ncbi.nlm.nih.gov/pubmed/?term=11093772 DM49DUI DI DM49DUI DM49DUI DN Tretinoin DM49DUI MI DTUGYRD DM49DUI MN P-glycoprotein 1 (ABCB1) DM49DUI MT DTP DM49DUI MA Substrate DM49DUI RN Carotenoids reverse multidrug resistance in cancer cells by interfering with ABC-transporters. Phytomedicine. 2012 Aug 15;19(11):977-87. DM49DUI RU https://doi.org/10.1016/j.phymed.2012.05.010 DM49DUI DI DM49DUI DM49DUI DN Tretinoin DM49DUI MI TTOD7B3 DM49DUI MN Retinoic acid receptor (RAR) DM49DUI MT DTT DM49DUI MA Binder DM49DUI RN Retinoids--which dermatological indications will benefit in the near future Skin Pharmacol Appl Skin Physiol. 2001 Sep-Oct;14(5):303-15. DM49DUI RU https://pubmed.ncbi.nlm.nih.gov/11586072 DM49DUI DI DM49DUI DM49DUI DN Tretinoin DM49DUI MI TT1Q3IE DM49DUI MN Retinoic acid receptor gamma (RARG) DM49DUI MT DTT DM49DUI MA Agonist DM49DUI RN Targacept active conformation search: a new method for predicting the conformation of a ligand bound to its protein target. J Med Chem. 2004 Dec 30;47(27):6831-9. DM49DUI RU https://pubmed.ncbi.nlm.nih.gov/15615532 DMU54QB DI DMU54QB DMU54QB DN Treximet DMU54QB MI TTSQIFT DMU54QB MN 5-HT 1A receptor (HTR1A) DMU54QB MT DTT DMU54QB MA Antagonist DMU54QB RN Clinical pipeline report, company report or official report of GlaxoSmithKline (2009). DMU54QB RU http://www.gsk.com/investors/product_pipeline/docs/gsk-pipeline-feb09.pdf DM0AEPG DI DM0AEPG DM0AEPG DN Triacetin DM0AEPG MI DEQU4N2 DM0AEPG MN Carboxyl ester lipase (CEL) DM0AEPG MT DME DM0AEPG MA Metabolism DM0AEPG RN Lipoamidase activity in normal and mutagenized pancreatic cholesterol esterase (bile salt-stimulated lipase). Biochem J. 1993 Apr 1;291 ( Pt 1):65-9. DM0AEPG RU https://www.ncbi.nlm.nih.gov/pubmed/?term=8471055 DM98IXF DI DM98IXF DM98IXF DN Triamcinolone DM98IXF MI TTYRL6O DM98IXF MN Glucocorticoid receptor (NR3C1) DM98IXF MT DTT DM98IXF MA Modulator DM98IXF RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. DM98IXF RU https://www.fda.gov/ DM7LRKD DI DM7LRKD DM7LRKD DN Triamcinolone diacetate DM7LRKD MI DE4LYSA DM7LRKD MN Cytochrome P450 3A4 (CYP3A4) DM7LRKD MT DME DM7LRKD MA Metabolism DM7LRKD RN Triamcinolone acetonide induced secondary adrenal insufficiency related to impaired CYP3A4 metabolism by coadministration of nefazodone. Pain Med. 2010 Jul;11(7):1132-5. DM7LRKD RU https://www.ncbi.nlm.nih.gov/pubmed/?term=20456080 DM7LRKD DI DM7LRKD DM7LRKD DN Triamcinolone diacetate DM7LRKD MI DEIBDNY DM7LRKD MN Cytochrome P450 3A5 (CYP3A5) DM7LRKD MT DME DM7LRKD MA Metabolism DM7LRKD RN Metabolic pathways of inhaled glucocorticoids by the CYP3A enzymes. Drug Metab Dispos. 2013 Feb;41(2):379-89. DM7LRKD RU https://www.ncbi.nlm.nih.gov/pubmed/?term=23143891 DM7LRKD DI DM7LRKD DM7LRKD DN Triamcinolone diacetate DM7LRKD MI DERD86B DM7LRKD MN Cytochrome P450 3A7 (CYP3A7) DM7LRKD MT DME DM7LRKD MA Metabolism DM7LRKD RN Metabolic pathways of inhaled glucocorticoids by the CYP3A enzymes. Drug Metab Dispos. 2013 Feb;41(2):379-89. DM7LRKD RU https://www.ncbi.nlm.nih.gov/pubmed/?term=23143891 DM2HU9I DI DM2HU9I DM2HU9I DN Triamterene DM2HU9I MI TTQM7TE DM2HU9I MN Amiloride-sensitive sodium channel (ENaC) DM2HU9I MT DTT DM2HU9I MA Blocker DM2HU9I RN Effects of the serine/threonine kinase SGK1 on the epithelial Na(+) channel (ENaC) and CFTR: implications for cystic fibrosis. Cell Physiol Biochem. 2001;11(4):209-18. DM2HU9I RU https://pubmed.ncbi.nlm.nih.gov/11509829 DM2HU9I DI DM2HU9I DM2HU9I DN Triamterene DM2HU9I MI DEJGDUW DM2HU9I MN Cytochrome P450 1A2 (CYP1A2) DM2HU9I MT DME DM2HU9I MA Metabolism DM2HU9I RN Rate-limiting biotransformation of triamterene is mediated by CYP1A2. Int J Clin Pharmacol Ther. 2005 Jul;43(7):327-34. DM2HU9I RU https://www.ncbi.nlm.nih.gov/pubmed/?term=16035375 DM2HU9I DI DM2HU9I DM2HU9I DN Triamterene DM2HU9I MI DTT79CX DM2HU9I MN Organic cation transporter 1 (SLC22A1) DM2HU9I MT DTP DM2HU9I MA Substrate DM2HU9I RN Identification of novel substrates and structure-activity relationship of cellular uptake mediated by human organic cation transporters 1 and 2. J Med Chem. 2013 Sep 26;56(18):7232-42. DM2HU9I RU http://www.ncbi.nlm.nih.gov/pubmed/23984907 DMETYK5 DI DMETYK5 DMETYK5 DN Triazolam DMETYK5 MI DE4LYSA DMETYK5 MN Cytochrome P450 3A4 (CYP3A4) DMETYK5 MT DME DMETYK5 MA Metabolism DMETYK5 RN In vitro metabolism of midazolam, triazolam, nifedipine, and testosterone by human liver microsomes and recombinant cytochromes p450: role of cyp3a4 and cyp3a5. Drug Metab Dispos. 2003 Jul;31(7):938-44. DMETYK5 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=12814972 DMETYK5 DI DMETYK5 DMETYK5 DN Triazolam DMETYK5 MI DEIBDNY DMETYK5 MN Cytochrome P450 3A5 (CYP3A5) DMETYK5 MT DME DMETYK5 MA Metabolism DMETYK5 RN In vitro metabolism of midazolam, triazolam, nifedipine, and testosterone by human liver microsomes and recombinant cytochromes p450: role of cyp3a4 and cyp3a5. Drug Metab Dispos. 2003 Jul;31(7):938-44. DMETYK5 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=12814972 DMETYK5 DI DMETYK5 DMETYK5 DN Triazolam DMETYK5 MI DERD86B DMETYK5 MN Cytochrome P450 3A7 (CYP3A7) DMETYK5 MT DME DMETYK5 MA Metabolism DMETYK5 RN Drug Interactions Flockhart Table DMETYK5 RU https://drug-interactions.medicine.iu.edu/Main-Table.aspx DMETYK5 DI DMETYK5 DMETYK5 DN Triazolam DMETYK5 MI TTPTXIN DMETYK5 MN Translocator protein (TSPO) DMETYK5 MT DTT DMETYK5 MA Modulator DMETYK5 RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. DMETYK5 RU https://www.fda.gov/ DMHAQCO DI DMHAQCO DMHAQCO DN Trichlormethiazide DMHAQCO MI DTVP67E DMHAQCO MN Organic anion transporter 3 (SLC22A8) DMHAQCO MT DTP DMHAQCO MA Substrate DMHAQCO RN Prediction of the overall renal tubular secretion and hepatic clearance of anionic drugs and a renal drug-drug interaction involving organic anion transporter 3 in humans by in vitro uptake experiments. Drug Metab Dispos. 2011 Jun;39(6):1031-8. DMHAQCO RU http://www.ncbi.nlm.nih.gov/pubmed/21383204 DMHAQCO DI DMHAQCO DMHAQCO DN Trichlormethiazide DMHAQCO MI TTS087L DMHAQCO MN Solute carrier family 12 member 1 (SLC12A1) DMHAQCO MT DTT DMHAQCO MA Blocker DMHAQCO RN Function and regulation of epithelial sodium transporters in the kidney of a salt-sensitive hypertensive rat model. J Hypertens. 2007 May;25(5):1065-72. DMHAQCO RU https://pubmed.ncbi.nlm.nih.gov/17414671 DMPWGBR DI DMPWGBR DMPWGBR DN Triclabendazole DMPWGBR MI DEJGDUW DMPWGBR MN Cytochrome P450 1A2 (CYP1A2) DMPWGBR MT DME DMPWGBR MA Metabolism DMPWGBR RN In vitro drug-drug interaction potential of sulfoxide and/or sulfone metabolites of albendazole, triclabendazole, aldicarb, methiocarb, montelukast and ziprasidone. Drug Metab Lett. 2018;12(2):101-116. DMPWGBR RU https://www.ncbi.nlm.nih.gov/pubmed/?term=30117405 DMPWGBR DI DMPWGBR DMPWGBR DN Triclabendazole DMPWGBR MI DE5IED8 DMPWGBR MN Cytochrome P450 2C9 (CYP2C9) DMPWGBR MT DME DMPWGBR MA Metabolism DMPWGBR RN In vitro drug-drug interaction potential of sulfoxide and/or sulfone metabolites of albendazole, triclabendazole, aldicarb, methiocarb, montelukast and ziprasidone. Drug Metab Lett. 2018;12(2):101-116. DMPWGBR RU https://www.ncbi.nlm.nih.gov/pubmed/?term=30117405 DMPWGBR DI DMPWGBR DMPWGBR DN Triclabendazole DMPWGBR MI DECB0K3 DMPWGBR MN Cytochrome P450 2D6 (CYP2D6) DMPWGBR MT DME DMPWGBR MA Metabolism DMPWGBR RN FDA Label of Egaten. The 2020 official website of the U.S. Food and Drug Administration. DMPWGBR RU https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/208711s000lbl.pdf DMPWGBR DI DMPWGBR DMPWGBR DN Triclabendazole DMPWGBR MI DE4LYSA DMPWGBR MN Cytochrome P450 3A4 (CYP3A4) DMPWGBR MT DME DMPWGBR MA Metabolism DMPWGBR RN In vitro drug-drug interaction potential of sulfoxide and/or sulfone metabolites of albendazole, triclabendazole, aldicarb, methiocarb, montelukast and ziprasidone. Drug Metab Lett. 2018;12(2):101-116. DMPWGBR RU https://www.ncbi.nlm.nih.gov/pubmed/?term=30117405 DMPWGBR DI DMPWGBR DMPWGBR DN Triclabendazole DMPWGBR MI DEGTFWK DMPWGBR MN Mephenytoin 4-hydroxylase (CYP2C19) DMPWGBR MT DME DMPWGBR MA Metabolism DMPWGBR RN In vitro drug-drug interaction potential of sulfoxide and/or sulfone metabolites of albendazole, triclabendazole, aldicarb, methiocarb, montelukast and ziprasidone. Drug Metab Lett. 2018;12(2):101-116. DMPWGBR RU https://www.ncbi.nlm.nih.gov/pubmed/?term=30117405 DMPWGBR DI DMPWGBR DMPWGBR DN Triclabendazole DMPWGBR MI TTEAID7 DMPWGBR MN Trypanosoma Cruzipain (Trypano CYSP) DMPWGBR MT DTT DMPWGBR MA Inhibitor DMPWGBR RN Colloid formation by drugs in simulated intestinal fluid. J Med Chem. 2010 May 27;53(10):4259-65. DMPWGBR RU https://pubmed.ncbi.nlm.nih.gov/20426472 DMZUR4N DI DMZUR4N DMZUR4N DN Triclosan DMZUR4N MI TTNX2CS DMZUR4N MN Plasmodium Enoyl-ACP reductase (Malaria fabI) DMZUR4N MT DTT DMZUR4N MA Binder DMZUR4N RN Novel molecular targets for antimalarial drug development. Chem Biol Drug Des. 2008 Apr;71(4):287-97. DMZUR4N RU https://pubmed.ncbi.nlm.nih.gov/18298458 DMVLHNI DI DMVLHNI DMVLHNI DN Tridihexethyl DMVLHNI MI TTH18TF DMVLHNI MN Muscarinic acetylcholine receptor M5 (CHRM5) DMVLHNI MT DTT DMVLHNI MA Binder DMVLHNI RN Effect of anticholinergic agents upon acquired nystagmus: a double-blind study of trihexyphenidyl and tridihexethyl chloride. Neurology. 1991 Nov;41(11):1737-41. DMVLHNI RU https://pubmed.ncbi.nlm.nih.gov/1944902 DMD2WPG DI DMD2WPG DMD2WPG DN Trientine DMD2WPG MI TTEYTKG DMD2WPG MN Carbonic anhydrase XIV (CA-XIV) DMD2WPG MT DTT DMD2WPG MA Inhibitor DMD2WPG RN Polyamines inhibit carbonic anhydrases by anchoring to the zinc-coordinated water molecule. J Med Chem. 2010 Aug 12;53(15):5511-22. DMD2WPG RU https://pubmed.ncbi.nlm.nih.gov/20590092 DMOL793 DI DMOL793 DMOL793 DN Trifarotene DMOL793 MI DEPKLMQ DMOL793 MN Cytochrome P450 2B6 (CYP2B6) DMOL793 MT DME DMOL793 MA Metabolism DMOL793 RN FDA label of Trifarotene. The 2020 official website of the U.S. Food and Drug Administration. DMOL793 RU https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/211527s000lbl.pdf DMOL793 DI DMOL793 DMOL793 DN Trifarotene DMOL793 MI DES5XRU DMOL793 MN Cytochrome P450 2C8 (CYP2C8) DMOL793 MT DME DMOL793 MA Metabolism DMOL793 RN FDA label of Trifarotene. The 2020 official website of the U.S. Food and Drug Administration. DMOL793 RU https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/211527s000lbl.pdf DMOL793 DI DMOL793 DMOL793 DN Trifarotene DMOL793 MI DE5IED8 DMOL793 MN Cytochrome P450 2C9 (CYP2C9) DMOL793 MT DME DMOL793 MA Metabolism DMOL793 RN FDA label of Trifarotene. The 2020 official website of the U.S. Food and Drug Administration. DMOL793 RU https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/211527s000lbl.pdf DMOL793 DI DMOL793 DMOL793 DN Trifarotene DMOL793 MI DE4LYSA DMOL793 MN Cytochrome P450 3A4 (CYP3A4) DMOL793 MT DME DMOL793 MA Metabolism DMOL793 RN FDA label of Trifarotene. The 2020 official website of the U.S. Food and Drug Administration. DMOL793 RU https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/211527s000lbl.pdf DMOL793 DI DMOL793 DMOL793 DN Trifarotene DMOL793 MI TT1Q3IE DMOL793 MN Retinoic acid receptor gamma (RARG) DMOL793 MT DTT DMOL793 MA Agonist DMOL793 RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health Human Services. 2019 DMOL793 RU https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/211527s000lbl.pdf DMKBYWI DI DMKBYWI DMKBYWI DN Trifluoperazine DMKBYWI MI TTV3NH6 DMKBYWI MN Calmodulin (CALM) DMKBYWI MT DTT DMKBYWI MA Inhibitor DMKBYWI RN Inhibitory effect of jujuboside A on glutamate-mediated excitatory signal pathway in hippocampus. Planta Med. 2003 Aug;69(8):692-5. DMKBYWI RU https://pubmed.ncbi.nlm.nih.gov/14531016 DMKBYWI DI DMKBYWI DMKBYWI DN Trifluoperazine DMKBYWI MI DEJGDUW DMKBYWI MN Cytochrome P450 1A2 (CYP1A2) DMKBYWI MT DME DMKBYWI MA Metabolism DMKBYWI RN Psychotropic Medications Metabolized by Cytochromes P450 (CYP) 1A2 Enzyme and Relevant Drug Interactions: Review of Articles DMKBYWI RU https://austinpublishinggroup.com/pharmacology-therapeutics/fulltext/ajpt-v4-id1085.php DMKBYWI DI DMKBYWI DMKBYWI DN Trifluoperazine DMKBYWI MI DEIASEZ DMKBYWI MN Dimethylaniline oxidase 2 (FMO2) DMKBYWI MT DME DMKBYWI MA Metabolism DMKBYWI RN Human FMO2-based microbial whole-cell catalysts for drug metabolite synthesis. Microb Cell Fact. 2015 Jun 12;14:82. DMKBYWI RU https://www.ncbi.nlm.nih.gov/pubmed/?term=26062974 DMKBYWI DI DMKBYWI DMKBYWI DN Trifluoperazine DMKBYWI MI DTUGYRD DMKBYWI MN P-glycoprotein 1 (ABCB1) DMKBYWI MT DTP DMKBYWI MA Substrate DMKBYWI RN Mammalian drug efflux transporters of the ATP binding cassette (ABC) family in multidrug resistance: A review of the past decade. Cancer Lett. 2016 Jan 1;370(1):153-64. DMKBYWI RU http://www.ncbi.nlm.nih.gov/pubmed/26499806 DMKFQJP DI DMKFQJP DMKFQJP DN Triflupromazine DMKFQJP MI TT0K1SC DMKFQJP MN 5-HT 2B receptor (HTR2B) DMKFQJP MT DTT DMKFQJP MA Antagonist DMKFQJP RN Some properties of 5-hydroxytryptamine receptors in the hindquarters of the rat. Br J Pharmacol. 1979 Sep;67(1):79-85. DMKFQJP RU https://pubmed.ncbi.nlm.nih.gov/497523 DMKFQJP DI DMKFQJP DMKFQJP DN Triflupromazine DMKFQJP MI DTUGYRD DMKFQJP MN P-glycoprotein 1 (ABCB1) DMKFQJP MT DTP DMKFQJP MA Substrate DMKFQJP RN Human intestinal transporter database: QSAR modeling and virtual profiling of drug uptake, efflux and interactions. Pharm Res. 2013 Apr;30(4):996-1007. DMKFQJP RU https://doi.org/10.1007/s11095-012-0935-x DMG2YBD DI DMG2YBD DMG2YBD DN Trifluridine DMG2YBD MI TTU6BFZ DMG2YBD MN Candida Thymidylate synthase (Candi TMP1) DMG2YBD MT DTT DMG2YBD MA Inhibitor DMG2YBD RN Trifluorothymidine induces cell death independently of p53. Nucleosides Nucleotides Nucleic Acids. 2008 Jun;27(6):699-703. DMG2YBD RU https://pubmed.ncbi.nlm.nih.gov/18600528 DMG2YBD DI DMG2YBD DMG2YBD DN Trifluridine DMG2YBD MI DT0EQPW DMG2YBD MN Concentrative nucleoside transporter 1 (SLC28A1) DMG2YBD MT DTP DMG2YBD MA Substrate DMG2YBD RN Lonsurf, INN-trifluridine/tipiracil. DMG2YBD RU https://s3-us-west-2.amazonaws.com/drugbank/cite_this/attachments/files/000/000/649/original/WC500206246.pdf?1531845997 DMG2YBD DI DMG2YBD DMG2YBD DN Trifluridine DMG2YBD MI DTXD1TQ DMG2YBD MN Equilibrative nucleoside transporter 1 (SLC29A1) DMG2YBD MT DTP DMG2YBD MA Substrate DMG2YBD RN Lonsurf, INN-trifluridine/tipiracil. DMG2YBD RU https://s3-us-west-2.amazonaws.com/drugbank/cite_this/attachments/files/000/000/649/original/WC500206246.pdf?1531845997 DMG2YBD DI DMG2YBD DMG2YBD DN Trifluridine DMG2YBD MI DTW78DQ DMG2YBD MN Equilibrative nucleoside transporter 2 (SLC29A2) DMG2YBD MT DTP DMG2YBD MA Substrate DMG2YBD RN Lonsurf, INN-trifluridine/tipiracil. DMG2YBD RU https://s3-us-west-2.amazonaws.com/drugbank/cite_this/attachments/files/000/000/649/original/WC500206246.pdf?1531845997 DMG2YBD DI DMG2YBD DMG2YBD DN Trifluridine DMG2YBD MI DTQ23VB DMG2YBD MN Organic anion transporter 1 (SLC22A6) DMG2YBD MT DTP DMG2YBD MA Substrate DMG2YBD RN Rat multispecific organic anion transporter 1 (rOAT1) transports zidovudine, acyclovir, and other antiviral nucleoside analogs. J Pharmacol Exp Ther. 2000 Sep;294(3):844-9. DMG2YBD RU http://www.ncbi.nlm.nih.gov/pubmed/10945832 DMG2YBD DI DMG2YBD DMG2YBD DN Trifluridine DMG2YBD MI DE4HCYL DMG2YBD MN Thymidine phosphorylase (TYMP) DMG2YBD MT DME DMG2YBD MA Metabolism DMG2YBD RN Phase I clinical study of three times a day oral administration of TAS-102 in patients with solid tumors. Cancer Invest. 2008 Oct;26(8):794-9. DMG2YBD RU https://www.ncbi.nlm.nih.gov/pubmed/?term=18798063 DMB19L8 DI DMB19L8 DMB19L8 DN Trihexyphenidyl DMB19L8 MI TTMXGCW DMB19L8 MN Adrenergic receptor beta-3 (ADRB3) DMB19L8 MT DTT DMB19L8 MA Agonist DMB19L8 RN Obesity: pathophysiology and clinical management. Curr Med Chem. 2009;16(4):506-21. DMB19L8 RU https://pubmed.ncbi.nlm.nih.gov/19199918 DMB19L8 DI DMB19L8 DMB19L8 DN Trihexyphenidyl DMB19L8 MI TTZ9SOR DMB19L8 MN Muscarinic acetylcholine receptor M1 (CHRM1) DMB19L8 MT DTT DMB19L8 MA Antagonist DMB19L8 RN The role of M1 muscarinic cholinergic receptors in the discriminative stimulus properties of N-desmethylclozapine and the atypical antipsychotic dr... Psychopharmacology (Berl). 2009 Apr;203(2):295-301. DMB19L8 RU https://pubmed.ncbi.nlm.nih.gov/18685832 DMP5A4T DI DMP5A4T DMP5A4T DN Trilaciclib DMP5A4T MI TT0PG8F DMP5A4T MN Cyclin-dependent kinase 4 (CDK4) DMP5A4T MT DTT DMP5A4T MA Inhibitor DMP5A4T RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health Human Services. 2021 DMP5A4T RU https://www.accessdata.fda.gov/drugsatfda_docs/label/2021/214200s000lbl.pdf DMP5A4T DI DMP5A4T DMP5A4T DN Trilaciclib DMP5A4T MI TTO0FDJ DMP5A4T MN Cyclin-dependent kinase 6 (CDK6) DMP5A4T MT DTT DMP5A4T MA Inhibitor DMP5A4T RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health Human Services. 2021 DMP5A4T RU https://www.accessdata.fda.gov/drugsatfda_docs/label/2021/214200s000lbl.pdf DMQZ9GF DI DMQZ9GF DMQZ9GF DN Trilostane DMQZ9GF MI DE4LYSA DMQZ9GF MN Cytochrome P450 3A4 (CYP3A4) DMQZ9GF MT DME DMQZ9GF MA Metabolism DMQZ9GF RN Long-term low-dose ketoconazole treatment in bilateral macronodular adrenal hyperplasia. Endocrinol Diabetes Metab Case Rep. 2014;2014:140083. DMQZ9GF RU https://www.ncbi.nlm.nih.gov/pubmed/?term=25535576 DMQZ9GF DI DMQZ9GF DMQZ9GF DN Trilostane DMQZ9GF MI TTOM3J0 DMQZ9GF MN Estrogen receptor beta (ESR2) DMQZ9GF MT DTT DMQZ9GF MA Modulator DMQZ9GF RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. DMQZ9GF RU https://www.fda.gov/ DM1QLST DI DM1QLST DM1QLST DN Trimazosin DM1QLST MI TT34BHT DM1QLST MN Adrenergic receptor alpha-1D (ADRA1D) DM1QLST MT DTT DM1QLST MA Modulator DM1QLST RN The hypotensive effect of trimazosin is not caused solely by alpha 1-adrenoceptor blockade. J Cardiovasc Pharmacol. 1984 Jan-Feb;6(1):142-50. DM1QLST RU https://pubmed.ncbi.nlm.nih.gov/6199597 DMPYQ7B DI DMPYQ7B DMPYQ7B DN Trimebutine DMPYQ7B MI DE4LYSA DMPYQ7B MN Cytochrome P450 3A4 (CYP3A4) DMPYQ7B MT DME DMPYQ7B MA Metabolism DMPYQ7B RN Integrated analysis on the physicochemical properties of dihydropyridine calcium channel blockers in grapefruit juice interactions. Curr Pharm Biotechnol. 2012 Jul;13(9):1705-17. DMPYQ7B RU https://www.ncbi.nlm.nih.gov/pubmed/?term=22039822 DMEMV9D DI DMEMV9D DMEMV9D DN Trimeprazine DMEMV9D MI TTTIBOJ DMEMV9D MN Histamine H1 receptor (H1R) DMEMV9D MT DTT DMEMV9D MA Antagonist DMEMV9D RN Effectiveness of alimemazine in controlling retching after Nissen fundoplication. J Pediatr Surg. 2005 Nov;40(11):1737-40. DMEMV9D RU https://pubmed.ncbi.nlm.nih.gov/16291162 DM0Q8MZ DI DM0Q8MZ DM0Q8MZ DN Trimethadione DM0Q8MZ MI DES5XRU DM0Q8MZ MN Cytochrome P450 2C8 (CYP2C8) DM0Q8MZ MT DME DM0Q8MZ MA Metabolism DM0Q8MZ RN Trimethadione metabolism by human liver cytochrome P450: evidence for the involvement of CYP2E1. Xenobiotica. 1998 Nov;28(11):1041-7. DM0Q8MZ RU https://www.ncbi.nlm.nih.gov/pubmed/?term=9879636 DM0Q8MZ DI DM0Q8MZ DM0Q8MZ DN Trimethadione DM0Q8MZ MI DE5IED8 DM0Q8MZ MN Cytochrome P450 2C9 (CYP2C9) DM0Q8MZ MT DME DM0Q8MZ MA Metabolism DM0Q8MZ RN Involvement of cytochrome P450 2C9, 2E1 and 3A4 in trimethadione N-demethylation in human microsomes. J Clin Pharm Ther. 2003 Dec;28(6):493-6. DM0Q8MZ RU https://www.ncbi.nlm.nih.gov/pubmed/?term=14651673 DM0Q8MZ DI DM0Q8MZ DM0Q8MZ DN Trimethadione DM0Q8MZ MI DEVDYN7 DM0Q8MZ MN Cytochrome P450 2E1 (CYP2E1) DM0Q8MZ MT DME DM0Q8MZ MA Metabolism DM0Q8MZ RN Involvement of cytochrome P450 2C9, 2E1 and 3A4 in trimethadione N-demethylation in human microsomes. J Clin Pharm Ther. 2003 Dec;28(6):493-6. DM0Q8MZ RU https://www.ncbi.nlm.nih.gov/pubmed/?term=14651673 DM0Q8MZ DI DM0Q8MZ DM0Q8MZ DN Trimethadione DM0Q8MZ MI DE4LYSA DM0Q8MZ MN Cytochrome P450 3A4 (CYP3A4) DM0Q8MZ MT DME DM0Q8MZ MA Metabolism DM0Q8MZ RN Involvement of cytochrome P450 2C9, 2E1 and 3A4 in trimethadione N-demethylation in human microsomes. J Clin Pharm Ther. 2003 Dec;28(6):493-6. DM0Q8MZ RU https://www.ncbi.nlm.nih.gov/pubmed/?term=14651673 DM0Q8MZ DI DM0Q8MZ DM0Q8MZ DN Trimethadione DM0Q8MZ MI DEGTFWK DM0Q8MZ MN Mephenytoin 4-hydroxylase (CYP2C19) DM0Q8MZ MT DME DM0Q8MZ MA Metabolism DM0Q8MZ RN Evaluation of child/adult pharmacokinetic differences from a database derived from the therapeutic drug literature. Toxicol Sci. 2002 Apr;66(2):185-200. DM0Q8MZ RU https://www.ncbi.nlm.nih.gov/pubmed/?term=11896285 DM0Q8MZ DI DM0Q8MZ DM0Q8MZ DN Trimethadione DM0Q8MZ MI TT729IR DM0Q8MZ MN Voltage-gated calcium channel alpha Cav3.1 (CACNA1G) DM0Q8MZ MT DTT DM0Q8MZ MA Blocker DM0Q8MZ RN Prophylactic and therapeutic functions of T-type calcium blockers against noise-induced hearing loss. Hear Res. 2007 Apr;226(1-2):52-60. DM0Q8MZ RU https://pubmed.ncbi.nlm.nih.gov/17291698 DMHF4IQ DI DMHF4IQ DMHF4IQ DN Trimethaphan DMHF4IQ MI TT4H1MQ DMHF4IQ MN Neuronal acetylcholine receptor alpha-4 (CHRNA4) DMHF4IQ MT DTT DMHF4IQ MA Antagonist DMHF4IQ RN Mechanism of long-lasting block of ganglion nicotinic receptors by mono-ammonium compounds with long aliphatic chain. J Auton Nerv Syst. 1994 Aug;48(3):231-40. DMHF4IQ RU https://pubmed.ncbi.nlm.nih.gov/7963258 DMM7CHK DI DMM7CHK DMM7CHK DN Trimethoprim DMM7CHK MI DES5XRU DMM7CHK MN Cytochrome P450 2C8 (CYP2C8) DMM7CHK MT DME DMM7CHK MA Metabolism DMM7CHK RN Pioglitazone is metabolised by CYP2C8 and CYP3A4 in vitro: potential for interactions with CYP2C8 inhibitors. Basic Clin Pharmacol Toxicol. 2006 Jul;99(1):44-51. DMM7CHK RU https://www.ncbi.nlm.nih.gov/pubmed/?term=16867170 DMM7CHK DI DMM7CHK DMM7CHK DN Trimethoprim DMM7CHK MI DE5IED8 DMM7CHK MN Cytochrome P450 2C9 (CYP2C9) DMM7CHK MT DME DMM7CHK MA Metabolism DMM7CHK RN Trimethoprim and sulfamethoxazole are selective inhibitors of CYP2C8 and CYP2C9, respectively. Drug Metab Dispos. 2002 Jun;30(6):631-5. DMM7CHK RU https://www.ncbi.nlm.nih.gov/pubmed/?term=12019187 DMM7CHK DI DMM7CHK DMM7CHK DN Trimethoprim DMM7CHK MI DE4LYSA DMM7CHK MN Cytochrome P450 3A4 (CYP3A4) DMM7CHK MT DME DMM7CHK MA Metabolism DMM7CHK RN Summary of information on human CYP enzymes: human P450 metabolism data. Drug Metab Rev. 2002 Feb-May;34(1-2):83-448. DMM7CHK RU https://www.ncbi.nlm.nih.gov/pubmed/?term=11996015 DMM7CHK DI DMM7CHK DMM7CHK DN Trimethoprim DMM7CHK MI TTYZVDJ DMM7CHK MN Dihydrofolate reductase (DHFR) DMM7CHK MT DTT DMM7CHK MA Modulator DMM7CHK RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. DMM7CHK RU https://www.fda.gov/ DMM7CHK DI DMM7CHK DMM7CHK DN Trimethoprim DMM7CHK MI DTT79CX DMM7CHK MN Organic cation transporter 1 (SLC22A1) DMM7CHK MT DTP DMM7CHK MA Substrate DMM7CHK RN Identification of novel substrates and structure-activity relationship of cellular uptake mediated by human organic cation transporters 1 and 2. J Med Chem. 2013 Sep 26;56(18):7232-42. DMM7CHK RU http://www.ncbi.nlm.nih.gov/pubmed/23984907 DMM7CHK DI DMM7CHK DMM7CHK DN Trimethoprim DMM7CHK MI DTUGYRD DMM7CHK MN P-glycoprotein 1 (ABCB1) DMM7CHK MT DTP DMM7CHK MA Substrate DMM7CHK RN Improving the prediction of the brain disposition for orally administered drugs using BDDCS. Adv Drug Deliv Rev. 2012 Jan;64(1):95-109. DMM7CHK RU https://doi.org/10.1016/j.addr.2011.12.008 DMDEA85 DI DMDEA85 DMDEA85 DN Trimetrexate DMDEA85 MI DTI7UX6 DMDEA85 MN Breast cancer resistance protein (ABCG2) DMDEA85 MT DTP DMDEA85 MA Substrate DMDEA85 RN Mutant Gly482 and Thr482 ABCG2 mediate high-level resistance to lipophilic antifolates. Cancer Chemother Pharmacol. 2006 Dec;58(6):826-34. DMDEA85 RU https://doi.org/10.1007/s00280-006-0230-9 DMDEA85 DI DMDEA85 DMDEA85 DN Trimetrexate DMDEA85 MI TT9SL3Q DMDEA85 MN Polypeptide deformylase (PDF) DMDEA85 MT DTT DMDEA85 MA Inhibitor DMDEA85 RN Expression and characterization of recombinant human-derived Pneumocystis carinii dihydrofolate reductase. Antimicrob Agents Chemother. 2000 Nov;44(11):3092-6. DMDEA85 RU https://pubmed.ncbi.nlm.nih.gov/11036028 DM1SC8M DI DM1SC8M DM1SC8M DN Trimipramine DM1SC8M MI DE5IED8 DM1SC8M MN Cytochrome P450 2C9 (CYP2C9) DM1SC8M MT DME DM1SC8M MA Metabolism DM1SC8M RN Effects of polymorphisms in CYP2D6, CYP2C9, and CYP2C19 on trimipramine pharmacokinetics. J Clin Psychopharmacol. 2003 Oct;23(5):459-66. DM1SC8M RU https://www.ncbi.nlm.nih.gov/pubmed/?term=14520122 DM1SC8M DI DM1SC8M DM1SC8M DN Trimipramine DM1SC8M MI DECB0K3 DM1SC8M MN Cytochrome P450 2D6 (CYP2D6) DM1SC8M MT DME DM1SC8M MA Metabolism DM1SC8M RN Galactorrhea during treatment with trimipramine. A case report. Pharmacopsychiatry. 2005 Nov;38(6):326-7. DM1SC8M RU https://www.ncbi.nlm.nih.gov/pubmed/?term=16342006 DM1SC8M DI DM1SC8M DM1SC8M DN Trimipramine DM1SC8M MI DEGTFWK DM1SC8M MN Mephenytoin 4-hydroxylase (CYP2C19) DM1SC8M MT DME DM1SC8M MA Metabolism DM1SC8M RN Effects of polymorphisms in CYP2D6, CYP2C9, and CYP2C19 on trimipramine pharmacokinetics. J Clin Psychopharmacol. 2003 Oct;23(5):459-66. DM1SC8M RU https://www.ncbi.nlm.nih.gov/pubmed/?term=14520122 DM1SC8M DI DM1SC8M DM1SC8M DN Trimipramine DM1SC8M MI TTAWNKZ DM1SC8M MN Norepinephrine transporter (NET) DM1SC8M MT DTT DM1SC8M MA Inhibitor DM1SC8M RN Antidepressants suppress production of the Th1 cytokine interferon-gamma, independent of monoamine transporter blockade. Eur Neuropsychopharmacol. 2006 Oct;16(7):481-90. DM1SC8M RU https://pubmed.ncbi.nlm.nih.gov/16388933 DM1SC8M DI DM1SC8M DM1SC8M DN Trimipramine DM1SC8M MI DEYGVN4 DM1SC8M MN UDP-glucuronosyltransferase 1A1 (UGT1A1) DM1SC8M MT DME DM1SC8M MA Metabolism DM1SC8M RN Role of human UGT2B10 in N-glucuronidation of tricyclic antidepressants, amitriptyline, imipramine, clomipramine, and trimipramine. Drug Metab Dispos. 2010 May;38(5):863-70. DM1SC8M RU https://www.ncbi.nlm.nih.gov/pubmed/?term=20133892 DMZBU15 DI DMZBU15 DMZBU15 DN Tripelennamine DMZBU15 MI TTTIBOJ DMZBU15 MN Histamine H1 receptor (H1R) DMZBU15 MT DTT DMZBU15 MA Antagonist DMZBU15 RN Involvement of histamine H1 and H2 receptors in the regulation of STAT-1 phosphorylation: inverse agonism exhibited by the receptor antagonists. Int Immunopharmacol. 2005 Jul;5(7-8):1299-309. DMZBU15 RU https://pubmed.ncbi.nlm.nih.gov/15914334 DM7SWIA DI DM7SWIA DM7SWIA DN Triprolidine DM7SWIA MI TTTIBOJ DM7SWIA MN Histamine H1 receptor (H1R) DM7SWIA MT DTT DM7SWIA MA Antagonist DM7SWIA RN Histamine excites rat lateral vestibular nuclear neurons through activation of post-synaptic H2 receptors. Neurosci Lett. 2008 Dec 19;448(1):15-9. DM7SWIA RU https://pubmed.ncbi.nlm.nih.gov/18938221 DM7SWIA DI DM7SWIA DM7SWIA DN Triprolidine DM7SWIA MI DTUGYRD DM7SWIA MN P-glycoprotein 1 (ABCB1) DM7SWIA MT DTP DM7SWIA MA Substrate DM7SWIA RN Central nervous system pharmacokinetics of the Mdr1 P-glycoprotein substrate CP-615,003: intersite differences and implications for human receptor occupancy projections from cerebrospinal fluid exposures. Drug Metab Dispos. 2007 Aug;35(8):1341-9. DM7SWIA RU https://doi.org/10.1124/dmd.106.013953 DMTK4LS DI DMTK4LS DMTK4LS DN Triptorelin DMTK4LS MI TT8R70G DMTK4LS MN Gonadotropin-releasing hormone receptor (GNRHR) DMTK4LS MT DTT DMTK4LS MA Modulator DMTK4LS RN Regulation of GnRH I receptor gene expression by the GnRH agonist triptorelin, estradiol, and progesterone in the gonadotroph-derived cell line alphaT3-1. Endocrine. 2006 Aug;30(1):139-44. DMTK4LS RU https://pubmed.ncbi.nlm.nih.gov/17185802 DMHB2C3 DI DMHB2C3 DMHB2C3 DN Trofosfamide DMHB2C3 MI DEPKLMQ DMHB2C3 MN Cytochrome P450 2B6 (CYP2B6) DMHB2C3 MT DME DMHB2C3 MA Metabolism DMHB2C3 RN Investigation of the major human hepatic cytochrome P450 involved in 4-hydroxylation and N-dechloroethylation of trofosfamide. Cancer Chemother Pharmacol. 1999;44(4):327-34. DMHB2C3 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=10447581 DMHB2C3 DI DMHB2C3 DMHB2C3 DN Trofosfamide DMHB2C3 MI DE4LYSA DMHB2C3 MN Cytochrome P450 3A4 (CYP3A4) DMHB2C3 MT DME DMHB2C3 MA Metabolism DMHB2C3 RN Investigation of the major human hepatic cytochrome P450 involved in 4-hydroxylation and N-dechloroethylation of trofosfamide. Cancer Chemother Pharmacol. 1999;44(4):327-34. DMHB2C3 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=10447581 DM3VFPD DI DM3VFPD DM3VFPD DN Troglitazone DM3VFPD MI DE6OQ3W DM3VFPD MN Cytochrome P450 1A1 (CYP1A1) DM3VFPD MT DME DM3VFPD MA Metabolism DM3VFPD RN Oxidation of troglitazone to a quinone-type metabolite catalyzed by cytochrome P-450 2C8 and P-450 3A4 in human liver microsomes. Drug Metab Dispos. 1999 Nov;27(11):1260-6. DM3VFPD RU https://www.ncbi.nlm.nih.gov/pubmed/?term=10534310 DM3VFPD DI DM3VFPD DM3VFPD DN Troglitazone DM3VFPD MI DES5XRU DM3VFPD MN Cytochrome P450 2C8 (CYP2C8) DM3VFPD MT DME DM3VFPD MA Metabolism DM3VFPD RN Effect of genetic polymorphisms in cytochrome p450 (CYP) 2C9 and CYP2C8 on the pharmacokinetics of oral antidiabetic drugs: clinical relevance. Clin Pharmacokinet. 2005;44(12):1209-25. DM3VFPD RU https://www.ncbi.nlm.nih.gov/pubmed/?term=16372821 DM3VFPD DI DM3VFPD DM3VFPD DN Troglitazone DM3VFPD MI DE5IED8 DM3VFPD MN Cytochrome P450 2C9 (CYP2C9) DM3VFPD MT DME DM3VFPD MA Metabolism DM3VFPD RN In vitro inhibitory effects of troglitazone and its metabolites on drug oxidation activities of human cytochrome P450 enzymes: comparison with pioglitazone and rosiglitazone. Xenobiotica. 2000 Jan;30(1):61-70. DM3VFPD RU https://www.ncbi.nlm.nih.gov/pubmed/?term=10659951 DM3VFPD DI DM3VFPD DM3VFPD DN Troglitazone DM3VFPD MI DE4LYSA DM3VFPD MN Cytochrome P450 3A4 (CYP3A4) DM3VFPD MT DME DM3VFPD MA Metabolism DM3VFPD RN Effect of genetic polymorphisms in cytochrome p450 (CYP) 2C9 and CYP2C8 on the pharmacokinetics of oral antidiabetic drugs: clinical relevance. Clin Pharmacokinet. 2005;44(12):1209-25. DM3VFPD RU https://www.ncbi.nlm.nih.gov/pubmed/?term=16372821 DM3VFPD DI DM3VFPD DM3VFPD DN Troglitazone DM3VFPD MI DEGTFWK DM3VFPD MN Mephenytoin 4-hydroxylase (CYP2C19) DM3VFPD MT DME DM3VFPD MA Metabolism DM3VFPD RN In vitro inhibitory effects of troglitazone and its metabolites on drug oxidation activities of human cytochrome P450 enzymes: comparison with pioglitazone and rosiglitazone. Xenobiotica. 2000 Jan;30(1):61-70. DM3VFPD RU https://www.ncbi.nlm.nih.gov/pubmed/?term=10659951 DM3VFPD DI DM3VFPD DM3VFPD DN Troglitazone DM3VFPD MI TTZMAO3 DM3VFPD MN Peroxisome proliferator-activated receptor gamma (PPAR-gamma) DM3VFPD MT DTT DM3VFPD MA Agonist DM3VFPD RN Expression of peroxisome proliferator-activated receptors (PPARs) in human urinary bladder carcinoma and growth inhibition by its agonists. Int J Cancer. 2003 May 1;104(5):597-602. DM3VFPD RU https://pubmed.ncbi.nlm.nih.gov/12594814 DM3VFPD DI DM3VFPD DM3VFPD DN Troglitazone DM3VFPD MI DEYGVN4 DM3VFPD MN UDP-glucuronosyltransferase 1A1 (UGT1A1) DM3VFPD MT DME DM3VFPD MA Metabolism DM3VFPD RN Troglitazone glucuronidation in human liver and intestine microsomes: high catalytic activity of UGT1A8 and UGT1A10. Drug Metab Dispos. 2002 Dec;30(12):1462-9. DM3VFPD RU https://www.ncbi.nlm.nih.gov/pubmed/?term=12433820 DM3VFPD DI DM3VFPD DM3VFPD DN Troglitazone DM3VFPD MI DEL5N6Y DM3VFPD MN UDP-glucuronosyltransferase 1A10 (UGT1A10) DM3VFPD MT DME DM3VFPD MA Metabolism DM3VFPD RN Troglitazone glucuronidation in human liver and intestine microsomes: high catalytic activity of UGT1A8 and UGT1A10. Drug Metab Dispos. 2002 Dec;30(12):1462-9. DM3VFPD RU https://www.ncbi.nlm.nih.gov/pubmed/?term=12433820 DM3VFPD DI DM3VFPD DM3VFPD DN Troglitazone DM3VFPD MI DEF2WXN DM3VFPD MN UDP-glucuronosyltransferase 1A3 (UGT1A3) DM3VFPD MT DME DM3VFPD MA Metabolism DM3VFPD RN Troglitazone glucuronidation in human liver and intestine microsomes: high catalytic activity of UGT1A8 and UGT1A10. Drug Metab Dispos. 2002 Dec;30(12):1462-9. DM3VFPD RU https://www.ncbi.nlm.nih.gov/pubmed/?term=12433820 DM3VFPD DI DM3VFPD DM3VFPD DN Troglitazone DM3VFPD MI DESD26P DM3VFPD MN UDP-glucuronosyltransferase 1A6 (UGT1A6) DM3VFPD MT DME DM3VFPD MA Metabolism DM3VFPD RN Troglitazone glucuronidation in human liver and intestine microsomes: high catalytic activity of UGT1A8 and UGT1A10. Drug Metab Dispos. 2002 Dec;30(12):1462-9. DM3VFPD RU https://www.ncbi.nlm.nih.gov/pubmed/?term=12433820 DM3VFPD DI DM3VFPD DM3VFPD DN Troglitazone DM3VFPD MI DE85D2P DM3VFPD MN UDP-glucuronosyltransferase 1A9 (UGT1A9) DM3VFPD MT DME DM3VFPD MA Metabolism DM3VFPD RN The UDP-glucuronosyltransferase 1A9 enzyme is a peroxisome proliferator-activated receptor alpha and gamma target gene. J Biol Chem. 2003 Apr 18;278(16):13975-83. DM3VFPD RU https://www.ncbi.nlm.nih.gov/pubmed/?term=12582161 DM3VFPD DI DM3VFPD DM3VFPD DN Troglitazone DM3VFPD MI DEB3CV1 DM3VFPD MN UDP-glucuronosyltransferase 2B7 (UGT2B7) DM3VFPD MT DME DM3VFPD MA Metabolism DM3VFPD RN Troglitazone glucuronidation in human liver and intestine microsomes: high catalytic activity of UGT1A8 and UGT1A10. Drug Metab Dispos. 2002 Dec;30(12):1462-9. DM3VFPD RU https://www.ncbi.nlm.nih.gov/pubmed/?term=12433820 DMUZNIG DI DMUZNIG DMUZNIG DN Troleandomycin DMUZNIG MI TTUWYEA DMUZNIG MN Bacterial 50S ribosomal RNA (Bact 50S rRNA) DMUZNIG MT DTT DMUZNIG MA Binder DMUZNIG RN Depression of colony formation by human thymus-derived lymphocytes with rifampin and other antimicrobial agents. J Infect Dis. 1981 Jun;143(6):832-5. DMUZNIG RU https://pubmed.ncbi.nlm.nih.gov/6972981 DMUZNIG DI DMUZNIG DMUZNIG DN Troleandomycin DMUZNIG MI DE4LYSA DMUZNIG MN Cytochrome P450 3A4 (CYP3A4) DMUZNIG MT DME DMUZNIG MA Metabolism DMUZNIG RN Effects of roxithromycin, erythromycin and troleandomycin on their N-demethylation by rat and human cytochrome P450 enzymes. Xenobiotica. 1996 Nov;26(11):1143-53. DMUZNIG RU https://www.ncbi.nlm.nih.gov/pubmed/?term=8948090 DMOBLGK DI DMOBLGK DMOBLGK DN Tromethamine DMOBLGK MI TTBFROQ DMOBLGK MN S-adenosylmethionine decarboxylase proenzyme (AMD1) DMOBLGK MT DTT DMOBLGK MA Inhibitor DMOBLGK RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMOBLGK RU https://pubmed.ncbi.nlm.nih.gov/17139284 DM1D90W DI DM1D90W DM1D90W DN Tropicamide DM1D90W MI TTQ3JTF DM1D90W MN Muscarinic acetylcholine receptor M4 (CHRM4) DM1D90W MT DTT DM1D90W MA Antagonist DM1D90W RN The muscarinic receptor antagonist tropicamide suppresses tremulous jaw movements in a rodent model of parkinsonian tremor: possible role of M4 rec... Psychopharmacology (Berl). 2007 Oct;194(3):347-59. DM1D90W RU https://pubmed.ncbi.nlm.nih.gov/17594079 DMNSJ7V DI DMNSJ7V DMNSJ7V DN Tropisetron DMNSJ7V MI TTPC4TU DMNSJ7V MN 5-HT 3A receptor (HTR3A) DMNSJ7V MT DTT DMNSJ7V MA Antagonist DMNSJ7V RN Emerging therapies for fibromyalgia. Expert Opin Emerg Drugs. 2008 Mar;13(1):53-62. DMNSJ7V RU https://pubmed.ncbi.nlm.nih.gov/18321148 DMNSJ7V DI DMNSJ7V DMNSJ7V DN Tropisetron DMNSJ7V MI DE5IED8 DMNSJ7V MN Cytochrome P450 2C9 (CYP2C9) DMNSJ7V MT DME DMNSJ7V MA Metabolism DMNSJ7V RN Summary of information on human CYP enzymes: human P450 metabolism data. Drug Metab Rev. 2002 Feb-May;34(1-2):83-448. DMNSJ7V RU https://www.ncbi.nlm.nih.gov/pubmed/?term=11996015 DMNSJ7V DI DMNSJ7V DMNSJ7V DN Tropisetron DMNSJ7V MI DECB0K3 DMNSJ7V MN Cytochrome P450 2D6 (CYP2D6) DMNSJ7V MT DME DMNSJ7V MA Metabolism DMNSJ7V RN Cytochrome P450 2D6 metabolism and 5-hydroxytryptamine type 3 receptor antagonists for postoperative nausea and vomiting. Med Sci Monit. 2005 Oct;11(10):RA322-8. DMNSJ7V RU https://www.ncbi.nlm.nih.gov/pubmed/?term=16192915 DMNSJ7V DI DMNSJ7V DMNSJ7V DN Tropisetron DMNSJ7V MI DE4LYSA DMNSJ7V MN Cytochrome P450 3A4 (CYP3A4) DMNSJ7V MT DME DMNSJ7V MA Metabolism DMNSJ7V RN Characterization of the cytochrome P450 enzymes involved in the in vitro metabolism of dolasetron. Comparison with other indole-containing 5-HT3 antagonists. Drug Metab Dispos. 1996 May;24(5):602-9. DMNSJ7V RU https://www.ncbi.nlm.nih.gov/pubmed/?term=8723743 DMX6RTG DI DMX6RTG DMX6RTG DN Trospium DMX6RTG MI TTH18TF DMX6RTG MN Muscarinic acetylcholine receptor M5 (CHRM5) DMX6RTG MT DTT DMX6RTG MA Antagonist DMX6RTG RN Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. DMX6RTG RU https://pubmed.ncbi.nlm.nih.gov/17016423 DM32XZT DI DM32XZT DM32XZT DN Trospium chloride DM32XZT MI DTE2B1D DM32XZT MN Organic anion transporting polypeptide 1A2 (SLCO1A2) DM32XZT MT DTP DM32XZT MA Substrate DM32XZT RN Expression of drug transporters and drug metabolizing enzymes in the bladder urothelium in man and affinity of the bladder spasmolytic trospium chloride to transporters likely involved in its pharmacokinetics. Mol Pharm. 2015 Jan 5;12(1):171-8. DM32XZT RU http://www.ncbi.nlm.nih.gov/pubmed/25466967 DM32XZT DI DM32XZT DM32XZT DN Trospium chloride DM32XZT MI DTT79CX DM32XZT MN Organic cation transporter 1 (SLC22A1) DM32XZT MT DTP DM32XZT MA Substrate DM32XZT RN Expression of drug transporters and drug metabolizing enzymes in the bladder urothelium in man and affinity of the bladder spasmolytic trospium chloride to transporters likely involved in its pharmacokinetics. Mol Pharm. 2015 Jan 5;12(1):171-8. DM32XZT RU http://www.ncbi.nlm.nih.gov/pubmed/25466967 DM32XZT DI DM32XZT DM32XZT DN Trospium chloride DM32XZT MI DTUGYRD DM32XZT MN P-glycoprotein 1 (ABCB1) DM32XZT MT DTP DM32XZT MA Substrate DM32XZT RN Expression of drug transporters and drug metabolizing enzymes in the bladder urothelium in man and affinity of the bladder spasmolytic trospium chloride to transporters likely involved in its pharmacokinetics. Mol Pharm. 2015 Jan 5;12(1):171-8. DM32XZT RU http://www.ncbi.nlm.nih.gov/pubmed/25466967 DM6AN32 DI DM6AN32 DM6AN32 DN Trovafloxacin DM6AN32 MI TTN6J5F DM6AN32 MN Bacterial DNA gyrase (Bact gyrase) DM6AN32 MT DTT DM6AN32 MA Modulator DM6AN32 RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. DM6AN32 RU https://www.fda.gov/ DMDHCK9 DI DMDHCK9 DMDHCK9 DN Trumenba DMDHCK9 MI TTUW6OP DMDHCK9 MN Complement factor H (CFH) DMDHCK9 MT DTT DMDHCK9 RN 2014 FDA drug approvals. Nat Rev Drug Discov. 2015 Feb;14(2):77-81. DMDHCK9 RU https://pubmed.ncbi.nlm.nih.gov/25633781 DM4NTMO DI DM4NTMO DM4NTMO DN TRYPAN BLUE DM4NTMO MI TTELIN2 DM4NTMO MN PTPN1 messenger RNA (PTPN1 mRNA) DM4NTMO MT DTT DM4NTMO MA Inhibitor DM4NTMO RN Evans Blue and other dyes as protein tyrosine phosphatase inhibitors. Bioorg Med Chem Lett. 2004 Apr 19;14(8):1923-6. DM4NTMO RU https://pubmed.ncbi.nlm.nih.gov/15050628 DMBZIVP DI DMBZIVP DMBZIVP DN Tubocurarine DMBZIVP MI TTF4E0J DMBZIVP MN Neuronal acetylcholine receptor alpha-2 (CHRNA2) DMBZIVP MT DTT DMBZIVP MA Antagonist DMBZIVP RN Pharmacological characteristics of the inhibition of nondepolarizing neuromuscular blocking agents at human adult muscle nicotinic acetylcholine receptor. Anesthesiology. 2009 Jun;110(6):1244-52. DMBZIVP RU https://pubmed.ncbi.nlm.nih.gov/19417616 DMBZIVP DI DMBZIVP DMBZIVP DN Tubocurarine DMBZIVP MI DTT79CX DMBZIVP MN Organic cation transporter 1 (SLC22A1) DMBZIVP MT DTP DMBZIVP MA Substrate DMBZIVP RN Human intestinal transporter database: QSAR modeling and virtual profiling of drug uptake, efflux and interactions. Pharm Res. 2013 Apr;30(4):996-1007. DMBZIVP RU https://doi.org/10.1007/s11095-012-0935-x DMBESUA DI DMBESUA DMBESUA DN Tucatinib DMBESUA MI TT6EO5L DMBESUA MN Erbb2 tyrosine kinase receptor (HER2) DMBESUA MT DTT DMBESUA MA Inhibitor DMBESUA RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health Human Services. 2020 DMBESUA RU https://www.accessdata.fda.gov/drugsatfda_docs/label/2020/213411s000lbl.pdf DM749I3 DI DM749I3 DM749I3 DN Ubrogepant DM749I3 MI TTY6O0Q DM749I3 MN Calcitonin gene-related peptide receptor (CGRPR) DM749I3 MT DTT DM749I3 MA Antagonist DM749I3 RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health Human Services. 2019 DM749I3 RU https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/211765s000lbl.pdf DM1IQRP DI DM1IQRP DM1IQRP DN Udenafil DM1IQRP MI DE4LYSA DM1IQRP MN Cytochrome P450 3A4 (CYP3A4) DM1IQRP MT DME DM1IQRP MA Metabolism DM1IQRP RN The contributions of cytochromes P450 3A4 and 3A5 to the metabolism of the phosphodiesterase type 5 inhibitors sildenafil, udenafil, and vardenafil. Drug Metab Dispos. 2008 Jun;36(6):986-90. DM1IQRP RU https://www.ncbi.nlm.nih.gov/pubmed/?term=18308836 DM1IQRP DI DM1IQRP DM1IQRP DN Udenafil DM1IQRP MI DEIBDNY DM1IQRP MN Cytochrome P450 3A5 (CYP3A5) DM1IQRP MT DME DM1IQRP MA Metabolism DM1IQRP RN The disposition of three phosphodiesterase type 5 inhibitors, vardenafil, sildenafil, and udenafil, is differently influenced by the CYP3A5 genotype. Pharmacogenet Genomics. 2011 Dec;21(12):820-8. DM1IQRP RU https://www.ncbi.nlm.nih.gov/pubmed/?term=21934637 DM1IQRP DI DM1IQRP DM1IQRP DN Udenafil DM1IQRP MI TTJ0IQB DM1IQRP MN Phosphodiesterase 5A (PDE5A) DM1IQRP MT DTT DM1IQRP MA Inhibitor DM1IQRP RN Increased expression of the nitric oxide synthase gene and protein in corpus cavernosum by repeated dosing of udenafil in a rat model of chemical d... Asian J Androl. 2009 Jul;11(4):435-42. DM1IQRP RU https://pubmed.ncbi.nlm.nih.gov/19465935 DMX3O0D DI DMX3O0D DMX3O0D DN UFT DMX3O0D MI DEJVYAZ DMX3O0D MN Cytochrome P450 2A6 (CYP2A6) DMX3O0D MT DME DMX3O0D MA Metabolism DMX3O0D RN UFT Capsules (uracil-tegafur). DMX3O0D RU https://hemonc.org/docs/packageinsert/uraciltegafur.pdf DMBNI20 DI DMBNI20 DMBNI20 DN Ulipristal DMBNI20 MI DEJGDUW DMBNI20 MN Cytochrome P450 1A2 (CYP1A2) DMBNI20 MT DME DMBNI20 MA Metabolism DMBNI20 RN The clinical pharmacology and pharmacokinetics of ulipristal acetate for the treatment of uterine fibroids. Reprod Sci. 2015 Apr;22(4):476-83. DMBNI20 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=25228633 DMBNI20 DI DMBNI20 DMBNI20 DN Ulipristal DMBNI20 MI DE4LYSA DMBNI20 MN Cytochrome P450 3A4 (CYP3A4) DMBNI20 MT DME DMBNI20 MA Metabolism DMBNI20 RN Emergency contraception. Gynecol Endocrinol. 2013 Mar;29 Suppl 1:1-14. DMBNI20 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=23437846 DMBNI20 DI DMBNI20 DMBNI20 DN Ulipristal DMBNI20 MI TTUV8G9 DMBNI20 MN Progesterone receptor (PGR) DMBNI20 MT DTT DMBNI20 MA Modulator DMBNI20 RN Mullard A: 2010 FDA drug approvals. Nat Rev Drug Discov. 2011 Feb;10(2):82-5. DMBNI20 RU https://pubmed.ncbi.nlm.nih.gov/21283092 DMYRBO1 DI DMYRBO1 DMYRBO1 DN Umbralisib DMYRBO1 MI TTA8PLI DMYRBO1 MN Casein kinase I epsilon (CSNK1E) DMYRBO1 MT DTT DMYRBO1 MA Inhibitor DMYRBO1 RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health Human Services. 2021 DMYRBO1 RU https://www.accessdata.fda.gov/drugsatfda_docs/label/2021/213176s000lbl.pdf DMYRBO1 DI DMYRBO1 DMYRBO1 DN Umbralisib DMYRBO1 MI TTGBPJE DMYRBO1 MN PI3-kinase delta (PIK3CD) DMYRBO1 MT DTT DMYRBO1 MA Inhibitor DMYRBO1 RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health Human Services. 2021 DMYRBO1 RU https://www.accessdata.fda.gov/drugsatfda_docs/label/2021/213176s000lbl.pdf DM4E8O9 DI DM4E8O9 DM4E8O9 DN Umeclidinium DM4E8O9 MI TTH18TF DM4E8O9 MN Muscarinic acetylcholine receptor M5 (CHRM5) DM4E8O9 MT DTT DM4E8O9 MA Modulator DM4E8O9 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7354). DM4E8O9 RU http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=7354 DMXNR04 DI DMXNR04 DMXNR04 DN Unoprostone DMXNR04 MI TT9B4N3 DMXNR04 MN Prostaglandin receptor (PTGR) DMXNR04 MT DTT DMXNR04 MA Modulator DMXNR04 RN Comparison of the vasoactive effects of the docosanoid unoprostone and selected prostanoids on isolated perfused retinal arterioles. Invest Ophthalmol Vis Sci. 2001 Jun;42(7):1499-504. DMXNR04 RU https://pubmed.ncbi.nlm.nih.gov/11381053 DM8T2OI DI DM8T2OI DM8T2OI DN Upadacitinib DM8T2OI MI DECB0K3 DM8T2OI MN Cytochrome P450 2D6 (CYP2D6) DM8T2OI MT DME DM8T2OI MA Metabolism DM8T2OI RN Population pharmacokinetics of upadacitinib using the immediate-release and extended-release formulations in healthy subjects and subjects with rheumatoid arthritis: analyses of phase I-III clinical trials. Clin Pharmacokinet. 2019 Aug;58(8):1045-1058. DM8T2OI RU https://www.ncbi.nlm.nih.gov/pubmed/?term=30945116 DM8T2OI DI DM8T2OI DM8T2OI DN Upadacitinib DM8T2OI MI DE4LYSA DM8T2OI MN Cytochrome P450 3A4 (CYP3A4) DM8T2OI MT DME DM8T2OI MA Metabolism DM8T2OI RN Population pharmacokinetics of upadacitinib using the immediate-release and extended-release formulations in healthy subjects and subjects with rheumatoid arthritis: analyses of phase I-III clinical trials. Clin Pharmacokinet. 2019 Aug;58(8):1045-1058. DM8T2OI RU https://www.ncbi.nlm.nih.gov/pubmed/?term=30945116 DM32B5U DI DM32B5U DM32B5U DN Upadacitinib DM32B5U MI TT6DM01 DM32B5U MN Janus kinase 1 (JAK-1) DM32B5U MT DTT DM32B5U MA Modulator DM32B5U RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health Human Services. 2019 DM32B5U RU https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/211675s000lbl.pdf DMHL7OB DI DMHL7OB DMHL7OB DN Uracil mustard DMHL7OB MI TTUTN1I DMHL7OB MN Human Deoxyribonucleic acid (hDNA) DMHL7OB MT DTT DMHL7OB MA Modulator DMHL7OB RN Excision of DNA adducts of nitrogen mustards by bacterial and mammalian 3-methyladenine-DNA glycosylases. Carcinogenesis. 1996 Apr;17(4):643-8. DMHL7OB RU https://pubmed.ncbi.nlm.nih.gov/8625472 DMD59GI DI DMD59GI DMD59GI DN Urapidil DMD59GI MI TTSQIFT DMD59GI MN 5-HT 1A receptor (HTR1A) DMD59GI MT DTT DMD59GI MA Agonist DMD59GI RN Urapidil. A reappraisal of its use in the management of hypertension. Drugs. 1998 Nov;56(5):929-55. DMD59GI RU https://pubmed.ncbi.nlm.nih.gov/9829161 DMD59GI DI DMD59GI DMD59GI DN Urapidil DMD59GI MI TTG28O6 DMD59GI MN Adrenergic receptor Alpha-1 (ADRA1) DMD59GI MT DTT DMD59GI MA Antagonist DMD59GI RN Urapidil. A reappraisal of its use in the management of hypertension. Drugs. 1998 Nov;56(5):929-55. DMD59GI RU https://pubmed.ncbi.nlm.nih.gov/9829161 DMUK75B DI DMUK75B DMUK75B DN Urea DMUK75B MI DTE2B1D DMUK75B MN Organic anion transporting polypeptide 1A2 (SLCO1A2) DMUK75B MT DTP DMUK75B MA Substrate DMUK75B RN Transcellular movement of hydroxyurea is mediated by specific solute carrier transporters. Exp Hematol. 2011 Apr;39(4):446-56. DMUK75B RU http://www.ncbi.nlm.nih.gov/pubmed/21256917 DMQTREB DI DMQTREB DMQTREB DN Uridine DMQTREB MI DT0EQPW DMQTREB MN Concentrative nucleoside transporter 1 (SLC28A1) DMQTREB MT DTP DMQTREB MA Substrate DMQTREB RN Electrophysiological recordings of CNT1 (SLC28A1) activity on Nanions SURFE2R N1. DMQTREB RU https://www.nanion.de/images/phocadownloadpap/Application_Notes/Nanion_APP_Note_SURFE2R_CNT1_09003.pdf DMQTREB DI DMQTREB DMQTREB DN Uridine DMQTREB MI DT82KPY DMQTREB MN Concentrative nucleoside transporter 2 (SLC28A2) DMQTREB MT DTP DMQTREB MA Substrate DMQTREB RN Transport of ribavirin across the rat and human placental barrier: Roles of nucleoside and ATP-binding cassette drug efflux transporters. Biochem Pharmacol. 2019 May;163:60-70. DMQTREB RU http://www.ncbi.nlm.nih.gov/pubmed/30716294 DMQTREB DI DMQTREB DMQTREB DN Uridine DMQTREB MI DENV24I DMQTREB MN Nicotinamide riboside kinase 1 (NRK1) DMQTREB MT DME DMQTREB MA Metabolism DMQTREB RN Nicotinamide riboside kinase structures reveal new pathways to NAD+. PLoS Biol. 2007 Oct 2;5(10):e263. DMQTREB RU https://www.ncbi.nlm.nih.gov/pubmed/?term=17914902 DMQTREB DI DMQTREB DMQTREB DN Uridine DMQTREB MI DE8DJ3N DMQTREB MN Nicotinamide riboside kinase 2 (NRK2) DMQTREB MT DME DMQTREB MA Metabolism DMQTREB RN Nicotinamide riboside kinase structures reveal new pathways to NAD+. PLoS Biol. 2007 Oct 2;5(10):e263. DMQTREB RU https://www.ncbi.nlm.nih.gov/pubmed/?term=17914902 DMQTREB DI DMQTREB DMQTREB DN Uridine DMQTREB MI TTO0IB8 DMQTREB MN Thymidine phosphorylase (TYMP) DMQTREB MT DTT DMQTREB MA Inhibitor DMQTREB RN Enzymatic activities of uridine and thymidine phosphorylase in normal and cancerous uterine cervical tissues. Hum Cell. 2007 Nov;20(4):107-10. DMQTREB RU https://pubmed.ncbi.nlm.nih.gov/17949350 DMQTREB DI DMQTREB DMQTREB DN Uridine DMQTREB MI DE478BP DMQTREB MN Uridine-cytidine kinase 1 (UCK1) DMQTREB MT DME DMQTREB MA Metabolism DMQTREB RN Phosphorylation of uridine and cytidine nucleoside analogs by two human uridine-cytidine kinases. Mol Pharmacol. 2001 May;59(5):1181-6. DMQTREB RU https://www.ncbi.nlm.nih.gov/pubmed/?term=11306702 DMQTREB DI DMQTREB DMQTREB DN Uridine DMQTREB MI DETN1O0 DMQTREB MN Uridine-cytidine kinase 2 (UCK2) DMQTREB MT DME DMQTREB MA Metabolism DMQTREB RN Phosphorylation of uridine and cytidine nucleoside analogs by two human uridine-cytidine kinases. Mol Pharmacol. 2001 May;59(5):1181-6. DMQTREB RU https://www.ncbi.nlm.nih.gov/pubmed/?term=11306702 DMG9HIA DI DMG9HIA DMG9HIA DN Urofollitropin DMG9HIA MI TTZFDBT DMG9HIA MN Follicle-stimulating hormone receptor (FSHR) DMG9HIA MT DTT DMG9HIA MA Binder DMG9HIA RN Follicle-stimulating hormone in clinical practice: an update. Treat Endocrinol. 2004;3(3):161-71. DMG9HIA RU https://pubmed.ncbi.nlm.nih.gov/16026112 DM0GOUD DI DM0GOUD DM0GOUD DN Urokinase DM0GOUD MI TTGY7WI DM0GOUD MN Urokinase-type plasminogen activator (PLAU) DM0GOUD MT DTT DM0GOUD MA Modulator DM0GOUD RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. DM0GOUD RU https://www.fda.gov/ DMCUT21 DI DMCUT21 DMCUT21 DN Ursodeoxycholic acid DMCUT21 MI DEOMLHG DMCUT21 MN Beta-hydroxysteroid dehydrogenase (hdhB) DMCUT21 MT DME DMCUT21 MA Metabolism DMCUT21 RN Identification, cloning, heterologous expression, and characterization of a NADPH-dependent 7beta-hydroxysteroid dehydrogenase from Collinsella aerofaciens. Appl Microbiol Biotechnol. 2011 Apr;90(1):127-35. DMCUT21 RU https://pubmed.ncbi.nlm.nih.gov/21181147 DMCUT21 DI DMCUT21 DMCUT21 DN Ursodeoxycholic acid DMCUT21 MI TTJBPN3 DMCUT21 MN Biliverdin reductase A (BLVRA) DMCUT21 MT DTT DMCUT21 MA Activator DMCUT21 RN Role of vitamin C transporters and biliverdin reductase in the dual pro-oxidant and anti-oxidant effect of biliary compounds on the placental-fetal... Toxicol Appl Pharmacol. 2008 Oct 15;232(2):327-36. DMCUT21 RU https://pubmed.ncbi.nlm.nih.gov/18706437 DMCUT21 DI DMCUT21 DMCUT21 DN Ursodeoxycholic acid DMCUT21 MI DT3D8F0 DMCUT21 MN Organic anion transporting polypeptide 1B1 (SLCO1B1) DMCUT21 MT DTP DMCUT21 MA Substrate DMCUT21 RN Transport of fluorescent chenodeoxycholic acid via the human organic anion transporters OATP1B1 and OATP1B3. J Lipid Res. 2006 Jun;47(6):1196-202. DMCUT21 RU http://www.ncbi.nlm.nih.gov/pubmed/16534140 DMCUT21 DI DMCUT21 DMCUT21 DN Ursodeoxycholic acid DMCUT21 MI TTOP832 DMCUT21 MN Solute carrier family 23 member 2 (SLC23A2) DMCUT21 MT DTT DMCUT21 MA Activator DMCUT21 RN Role of vitamin C transporters and biliverdin reductase in the dual pro-oxidant and anti-oxidant effect of biliary compounds on the placental-fetal... Toxicol Appl Pharmacol. 2008 Oct 15;232(2):327-36. DMCUT21 RU https://pubmed.ncbi.nlm.nih.gov/18706437 DMHTYK3 DI DMHTYK3 DMHTYK3 DN Ustekinumab DMHTYK3 MI TTRTK6Y DMHTYK3 MN Interleukin-12 alpha (IL12A) DMHTYK3 MT DTT DMHTYK3 RN Hughes B: 2009 FDA drug approvals. Nat Rev Drug Discov. 2010 Feb;9(2):89-92. DMHTYK3 RU https://pubmed.ncbi.nlm.nih.gov/20118952 DMHTYK3 DI DMHTYK3 DMHTYK3 DN Ustekinumab DMHTYK3 MI TTC1GLB DMHTYK3 MN Interleukin-23 (IL23) DMHTYK3 MT DTT DMHTYK3 RN Hughes B: 2009 FDA drug approvals. Nat Rev Drug Discov. 2010 Feb;9(2):89-92. DMHTYK3 RU https://pubmed.ncbi.nlm.nih.gov/20118952 DMHTYK3 DI DMHTYK3 DMHTYK3 DN Ustekinumab DMHTYK3 MI TT9SL3Q DMHTYK3 MN Polypeptide deformylase (PDF) DMHTYK3 MT DTT DMHTYK3 MA Inhibitor DMHTYK3 RN Novel Saccharomyces cerevisiae screen identifies WR99210 analogues that inhibit Mycobacterium tuberculosis dihydrofolate reductase. Antimicrob Agents Chemother. 2002 Nov;46(11):3362-9. DMHTYK3 RU https://pubmed.ncbi.nlm.nih.gov/12384337 DMA630M DI DMA630M DMA630M DN Vaccinia immune globulin DMA630M MI TTOP3CH DMA630M MN Immunoglobulin unspecific (Ig) DMA630M MT DTT DMA630M MA Modulator DMA630M RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015 DMA630M RU https://www.accessdata.fda.gov/scripts/cder/drugsatfda/ DMHKS94 DI DMHKS94 DMHKS94 DN Valaciclovir DMHKS94 MI DTW7AE3 DMHKS94 MN Alanine/serine/cysteine/threonine transporter 2 (SLC1A5) DMHKS94 MT DTP DMHKS94 MA Substrate DMHKS94 RN Transport of amino acid-based prodrugs by the Na+- and Cl(-) -coupled amino acid transporter ATB0,+ and expression of the transporter in tissues amenable for drug delivery. J Pharmacol Exp Ther. 2004 Mar;308(3):1138-47. DMHKS94 RU http://www.ncbi.nlm.nih.gov/pubmed/14617696 DMHKS94 DI DMHKS94 DMHKS94 DN Valaciclovir DMHKS94 MI TTIU7X1 DMHKS94 MN Herpes simplex virus DNA polymerase UL30 (HSV UL30) DMHKS94 MT DTT DMHKS94 MA Inhibitor DMHKS94 RN Extensive oral shedding of human herpesvirus 8 in a renal allograft recipient. Oral Microbiol Immunol. 2009 Apr;24(2):109-15. DMHKS94 RU https://pubmed.ncbi.nlm.nih.gov/19239637 DMHKS94 DI DMHKS94 DMHKS94 DN Valaciclovir DMHKS94 MI DTVP67E DMHKS94 MN Organic anion transporter 3 (SLC22A8) DMHKS94 MT DTP DMHKS94 MA Substrate DMHKS94 RN Human organic anion transporters and human organic cation transporters mediate renal antiviral transport. J Pharmacol Exp Ther. 2002 Mar;300(3):918-24. DMHKS94 RU http://www.ncbi.nlm.nih.gov/pubmed/11861798 DMHKS94 DI DMHKS94 DMHKS94 DN Valaciclovir DMHKS94 MI DT9G7XN DMHKS94 MN Peptide transporter 1 (SLC15A1) DMHKS94 MT DTP DMHKS94 MA Substrate DMHKS94 RN Valacyclovir: a substrate for the intestinal and renal peptide transporters PEPT1 and PEPT2. Biochem Biophys Res Commun. 1998 May 19;246(2):470-5. DMHKS94 RU http://www.ncbi.nlm.nih.gov/pubmed/9610386 DMHKS94 DI DMHKS94 DMHKS94 DN Valaciclovir DMHKS94 MI DT8QKNP DMHKS94 MN Peptide transporter 2 (SLC15A2) DMHKS94 MT DTP DMHKS94 MA Substrate DMHKS94 RN Valacyclovir: a substrate for the intestinal and renal peptide transporters PEPT1 and PEPT2. Biochem Biophys Res Commun. 1998 May 19;246(2):470-5. DMHKS94 RU http://www.ncbi.nlm.nih.gov/pubmed/9610386 DM5I1CE DI DM5I1CE DM5I1CE DN Valacyclovir Hydrochloride DM5I1CE MI TTIU7X1 DM5I1CE MN Herpes simplex virus DNA polymerase UL30 (HSV UL30) DM5I1CE MT DTT DM5I1CE MA Modulator DM5I1CE RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. DM5I1CE RU https://www.fda.gov/ DMQSA2V DI DMQSA2V DMQSA2V DN Valbenazine tosylate DMQSA2V MI TTNZRI3 DMQSA2V MN Synaptic vesicle amine transporter (SLC18A2) DMQSA2V MT DTT DMQSA2V MA Modulator DMQSA2V RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. DMQSA2V RU https://www.fda.gov/ DMAY7H4 DI DMAY7H4 DMAY7H4 DN Valdecoxib DMAY7H4 MI DE5IED8 DMAY7H4 MN Cytochrome P450 2C9 (CYP2C9) DMAY7H4 MT DME DMAY7H4 MA Metabolism DMAY7H4 RN Genetically based impairment in CYP2C8- and CYP2C9-dependent NSAID metabolism as a risk factor for gastrointestinal bleeding: is a combination of pharmacogenomics and metabolomics required to improve personalized medicine? Expert Opin Drug Metab Toxicol. 2009 Jun;5(6):607-20. DMAY7H4 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=19422321 DMAY7H4 DI DMAY7H4 DMAY7H4 DN Valdecoxib DMAY7H4 MI DE4LYSA DMAY7H4 MN Cytochrome P450 3A4 (CYP3A4) DMAY7H4 MT DME DMAY7H4 MA Metabolism DMAY7H4 RN Simultaneous assessment of drug interactions with low- and high-extraction opioids: application to parecoxib effects on the pharmacokinetics and pharmacodynamics of fentanyl and alfentanil. Anesthesiology. 2003 Apr;98(4):853-61. DMAY7H4 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=12657846 DMAY7H4 DI DMAY7H4 DMAY7H4 DN Valdecoxib DMAY7H4 MI TTVKILB DMAY7H4 MN Prostaglandin G/H synthase 2 (COX-2) DMAY7H4 MT DTT DMAY7H4 MA Inhibitor DMAY7H4 RN Biochemical mechanisms of New Molecular Entities (NMEs) approved by United States FDA during 2001-2004: mechanisms leading to optimal efficacy and ... Curr Top Med Chem. 2006;6(5):461-78. DMAY7H4 RU https://pubmed.ncbi.nlm.nih.gov/16719803 DMAY7H4 DI DMAY7H4 DMAY7H4 DN Valdecoxib DMAY7H4 MI DE85D2P DMAY7H4 MN UDP-glucuronosyltransferase 1A9 (UGT1A9) DMAY7H4 MT DME DMAY7H4 MA Metabolism DMAY7H4 RN Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. DMAY7H4 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=19515014 DMS2IUH DI DMS2IUH DMS2IUH DN Valganciclovir DMS2IUH MI DTW7AE3 DMS2IUH MN Alanine/serine/cysteine/threonine transporter 2 (SLC1A5) DMS2IUH MT DTP DMS2IUH MA Substrate DMS2IUH RN Transport of amino acid esters and the amino-acid-based prodrug valganciclovir by the amino acid transporter ATB(0,+). Pharm Res. 2004 Jul;21(7):1303-10. DMS2IUH RU http://www.ncbi.nlm.nih.gov/pubmed/15290873 DMS2IUH DI DMS2IUH DMS2IUH DN Valganciclovir DMS2IUH MI TTIU7X1 DMS2IUH MN Herpes simplex virus DNA polymerase UL30 (HSV UL30) DMS2IUH MT DTT DMS2IUH MA Inhibitor DMS2IUH RN Drug targets in cytomegalovirus infection. Infect Disord Drug Targets. 2009 Apr;9(2):201-22. DMS2IUH RU https://pubmed.ncbi.nlm.nih.gov/19275707 DMS2IUH DI DMS2IUH DMS2IUH DN Valganciclovir DMS2IUH MI DT9G7XN DMS2IUH MN Peptide transporter 1 (SLC15A1) DMS2IUH MT DTP DMS2IUH MA Substrate DMS2IUH RN Transport of valganciclovir, a ganciclovir prodrug, via peptide transporters PEPT1 and PEPT2. J Pharm Sci. 2000 Jun;89(6):781-9. DMS2IUH RU http://www.ncbi.nlm.nih.gov/pubmed/10824137 DMCFE9I DI DMCFE9I DMCFE9I DN Valproate DMCFE9I MI DEJVYAZ DMCFE9I MN Cytochrome P450 2A6 (CYP2A6) DMCFE9I MT DME DMCFE9I MA Metabolism DMCFE9I RN Psychotropic drug interactions with valproate. Clin Neuropharmacol. 2005 Mar-Apr;28(2):96-101. DMCFE9I RU https://www.ncbi.nlm.nih.gov/pubmed/?term=15795555 DMCFE9I DI DMCFE9I DMCFE9I DN Valproate DMCFE9I MI DEPKLMQ DMCFE9I MN Cytochrome P450 2B6 (CYP2B6) DMCFE9I MT DME DMCFE9I MA Metabolism DMCFE9I RN Insights into CYP2B6-mediated drug-drug interactions. Acta Pharm Sin B. 2016 Sep;6(5):413-425. DMCFE9I RU https://www.ncbi.nlm.nih.gov/pubmed/?term=27709010 DMCFE9I DI DMCFE9I DMCFE9I DN Valproate DMCFE9I MI DE5IED8 DMCFE9I MN Cytochrome P450 2C9 (CYP2C9) DMCFE9I MT DME DMCFE9I MA Metabolism DMCFE9I RN A mechanistic approach to antiepileptic drug interactions. Ann Pharmacother. 1998 May;32(5):554-63. DMCFE9I RU https://www.ncbi.nlm.nih.gov/pubmed/?term=9606477 DMCFE9I DI DMCFE9I DMCFE9I DN Valproate DMCFE9I MI DEIBDNY DMCFE9I MN Cytochrome P450 3A5 (CYP3A5) DMCFE9I MT DME DMCFE9I MA Metabolism DMCFE9I RN Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. DMCFE9I RU https://www.ncbi.nlm.nih.gov/pubmed/?term=19515014 DMCFE9I DI DMCFE9I DMCFE9I DN Valproate DMCFE9I MI TTRZQE3 DMCFE9I MN Glycogen synthase kinase-3 alpha (GSK-3A) DMCFE9I MT DTT DMCFE9I MA Inhibitor DMCFE9I RN Challenges and new opportunities in the investigation of new drug therapies to treat frontotemporal dementia. Expert Opin Ther Targets. 2008 Nov;12(11):1367-76. DMCFE9I RU https://pubmed.ncbi.nlm.nih.gov/18851693 DMCFE9I DI DMCFE9I DMCFE9I DN Valproate DMCFE9I MI TTBH0VX DMCFE9I MN Histone deacetylase (HDAC) DMCFE9I MT DTT DMCFE9I MA Inhibitor DMCFE9I RN Transcription-independent heritability of induced histone modifications in the mouse preimplantation embryo. PLoS One. 2009 Jun 30;4(6):e6086. DMCFE9I RU https://pubmed.ncbi.nlm.nih.gov/19564914 DMCFE9I DI DMCFE9I DMCFE9I DN Valproate DMCFE9I MI DEGTFWK DMCFE9I MN Mephenytoin 4-hydroxylase (CYP2C19) DMCFE9I MT DME DMCFE9I MA Metabolism DMCFE9I RN A mechanistic approach to antiepileptic drug interactions. Ann Pharmacother. 1998 May;32(5):554-63. DMCFE9I RU https://www.ncbi.nlm.nih.gov/pubmed/?term=9606477 DMCFE9I DI DMCFE9I DMCFE9I DN Valproate DMCFE9I MI DTLT3UG DMCFE9I MN Monocarboxylate transporter 2 (SLC16A7) DMCFE9I MT DTP DMCFE9I MA Substrate DMCFE9I RN Monocarboxylate Transporters in Drug Disposition: Role in the Toxicokinetics and Toxicodynamics of the Drug of Abuse GHB. DMCFE9I RU https://www.njacs.org/wp-content/docs/2010-Spring-DrugMet-Marilyn_Morris.pdf DMCFE9I DI DMCFE9I DMCFE9I DN Valproate DMCFE9I MI DTFI42L DMCFE9I MN Multidrug resistance-associated protein 2 (ABCC2) DMCFE9I MT DTP DMCFE9I MA Substrate DMCFE9I RN Pharmacogenetics of membrane transporters: an update on current approaches. Mol Biotechnol. 2010 Feb;44(2):152-67. DMCFE9I RU https://doi.org/10.1007/s12033-009-9220-6 DMCFE9I DI DMCFE9I DMCFE9I DN Valproate DMCFE9I MI DE073H6 DMCFE9I MN Prostaglandin G/H synthase 1 (COX-1) DMCFE9I MT DME DMCFE9I MA Metabolism DMCFE9I RN Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. DMCFE9I RU https://www.ncbi.nlm.nih.gov/pubmed/?term=19515014 DMCFE9I DI DMCFE9I DMCFE9I DN Valproate DMCFE9I MI DEYGVN4 DMCFE9I MN UDP-glucuronosyltransferase 1A1 (UGT1A1) DMCFE9I MT DME DMCFE9I MA Metabolism DMCFE9I RN Effect of aging on glucuronidation of valproic acid in human liver microsomes and the role of UDP-glucuronosyltransferase UGT1A4, UGT1A8, and UGT1A10. Drug Metab Dispos. 2009 Jan;37(1):229-36. DMCFE9I RU https://www.ncbi.nlm.nih.gov/pubmed/?term=18838507 DMCFE9I DI DMCFE9I DMCFE9I DN Valproate DMCFE9I MI DEL5N6Y DMCFE9I MN UDP-glucuronosyltransferase 1A10 (UGT1A10) DMCFE9I MT DME DMCFE9I MA Metabolism DMCFE9I RN UDP glucuronosyltransferase (UGT) 1A6 pharmacogenetics: II. Functional impact of the three most common nonsynonymous UGT1A6 polymorphisms (S7A, T181A, and R184S). J Pharmacol Exp Ther. 2005 Jun;313(3):1340-6. DMCFE9I RU https://www.ncbi.nlm.nih.gov/pubmed/?term=15761113 DMCFE9I DI DMCFE9I DMCFE9I DN Valproate DMCFE9I MI DEF2WXN DMCFE9I MN UDP-glucuronosyltransferase 1A3 (UGT1A3) DMCFE9I MT DME DMCFE9I MA Metabolism DMCFE9I RN Effect of aging on glucuronidation of valproic acid in human liver microsomes and the role of UDP-glucuronosyltransferase UGT1A4, UGT1A8, and UGT1A10. Drug Metab Dispos. 2009 Jan;37(1):229-36. DMCFE9I RU https://www.ncbi.nlm.nih.gov/pubmed/?term=18838507 DMCFE9I DI DMCFE9I DMCFE9I DN Valproate DMCFE9I MI DESD26P DMCFE9I MN UDP-glucuronosyltransferase 1A6 (UGT1A6) DMCFE9I MT DME DMCFE9I MA Metabolism DMCFE9I RN UDP glucuronosyltransferase (UGT) 1A6 pharmacogenetics: II. Functional impact of the three most common nonsynonymous UGT1A6 polymorphisms (S7A, T181A, and R184S). J Pharmacol Exp Ther. 2005 Jun;313(3):1340-6. DMCFE9I RU https://www.ncbi.nlm.nih.gov/pubmed/?term=15761113 DMCFE9I DI DMCFE9I DMCFE9I DN Valproate DMCFE9I MI DE85D2P DMCFE9I MN UDP-glucuronosyltransferase 1A9 (UGT1A9) DMCFE9I MT DME DMCFE9I MA Metabolism DMCFE9I RN Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. DMCFE9I RU https://www.ncbi.nlm.nih.gov/pubmed/?term=19515014 DMCFE9I DI DMCFE9I DMCFE9I DN Valproate DMCFE9I MI DEB3CV1 DMCFE9I MN UDP-glucuronosyltransferase 2B7 (UGT2B7) DMCFE9I MT DME DMCFE9I MA Metabolism DMCFE9I RN Pharmacokinetic and pharmacodynamic interaction of lorazepam and valproic acid in relation to UGT2B7 genetic polymorphism in healthy subjects. Clin Pharmacol Ther. 2008 Apr;83(4):595-600. DMCFE9I RU https://www.ncbi.nlm.nih.gov/pubmed/?term=17687269 DMOYJFK DI DMOYJFK DMOYJFK DN Valrubicin DMOYJFK MI TT0IHXV DMOYJFK MN DNA topoisomerase II (TOP2) DMOYJFK MT DTT DMOYJFK MA Inhibitor DMOYJFK RN Metabolic activation of N-acylanthracyclines precedes their interaction with DNA topoisomerase II. NCI Monogr. 1987;(4):111-5. DMOYJFK RU https://pubmed.ncbi.nlm.nih.gov/3041237 DMREUQ6 DI DMREUQ6 DMREUQ6 DN Valsartan DMREUQ6 MI TT8DBY3 DMREUQ6 MN Angiotensin II receptor type-1 (AGTR1) DMREUQ6 MT DTT DMREUQ6 MA Antagonist DMREUQ6 RN Radioligand binding assays: application of [(125)I]angiotensin II receptor binding. Methods Mol Biol. 2009;552:131-41. DMREUQ6 RU https://pubmed.ncbi.nlm.nih.gov/19513646 DMREUQ6 DI DMREUQ6 DMREUQ6 DN Valsartan DMREUQ6 MI DE5IED8 DMREUQ6 MN Cytochrome P450 2C9 (CYP2C9) DMREUQ6 MT DME DMREUQ6 MA Metabolism DMREUQ6 RN In vitro inhibition screening of human hepatic P450 enzymes by five angiotensin-II receptor antagonists. Eur J Clin Pharmacol. 2000 May;56(2):135-40. DMREUQ6 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=10877007 DMREUQ6 DI DMREUQ6 DMREUQ6 DN Valsartan DMREUQ6 MI DTFI42L DMREUQ6 MN Multidrug resistance-associated protein 2 (ABCC2) DMREUQ6 MT DTP DMREUQ6 MA Substrate DMREUQ6 RN Involvement of transporters in the hepatic uptake and biliary excretion of valsartan, a selective antagonist of the angiotensin II AT1-receptor, in humans. Drug Metab Dispos. 2006 Jul;34(7):1247-54. DMREUQ6 RU http://www.ncbi.nlm.nih.gov/pubmed/16624871 DMREUQ6 DI DMREUQ6 DMREUQ6 DN Valsartan DMREUQ6 MI DTVP67E DMREUQ6 MN Organic anion transporter 3 (SLC22A8) DMREUQ6 MT DTP DMREUQ6 MA Substrate DMREUQ6 RN Prediction of the overall renal tubular secretion and hepatic clearance of anionic drugs and a renal drug-drug interaction involving organic anion transporter 3 in humans by in vitro uptake experiments. Drug Metab Dispos. 2011 Jun;39(6):1031-8. DMREUQ6 RU http://www.ncbi.nlm.nih.gov/pubmed/21383204 DMREUQ6 DI DMREUQ6 DMREUQ6 DN Valsartan DMREUQ6 MI DT3D8F0 DMREUQ6 MN Organic anion transporting polypeptide 1B1 (SLCO1B1) DMREUQ6 MT DTP DMREUQ6 MA Substrate DMREUQ6 RN Regulation of Organic Anion Transporting Polypeptides (OATP) 1B1- and OATP1B3-Mediated Transport: An Updated Review in the Context of OATP-Mediated Drug-Drug Interactions. Int J Mol Sci. 2018 Mar 14;19(3). pii: E855. DMREUQ6 RU http://www.ncbi.nlm.nih.gov/pubmed/29538325 DMREUQ6 DI DMREUQ6 DMREUQ6 DN Valsartan DMREUQ6 MI DT9C1TS DMREUQ6 MN Organic anion transporting polypeptide 1B3 (SLCO1B3) DMREUQ6 MT DTP DMREUQ6 MA Substrate DMREUQ6 RN Involvement of transporters in the hepatic uptake and biliary excretion of valsartan, a selective antagonist of the angiotensin II AT1-receptor, in humans. Drug Metab Dispos. 2006 Jul;34(7):1247-54. DMREUQ6 RU http://www.ncbi.nlm.nih.gov/pubmed/16624871 DMREUQ6 DI DMREUQ6 DMREUQ6 DN Valsartan DMREUQ6 MI DT9G7XN DMREUQ6 MN Peptide transporter 1 (SLC15A1) DMREUQ6 MT DTP DMREUQ6 MA Substrate DMREUQ6 RN High-affinity interaction of sartans with H+/peptide transporters. Drug Metab Dispos. 2009 Jan;37(1):143-9. DMREUQ6 RU http://www.ncbi.nlm.nih.gov/pubmed/18824524 DMK7T1Q DI DMK7T1Q DMK7T1Q DN Vancomycin DMK7T1Q MI DE035GU DMK7T1Q MN D-alanylalanine synthetase (ddl) DMK7T1Q MT DME DMK7T1Q MA Metabolism DMK7T1Q RN vanG element insertions within a conserved chromosomal site conferring vancomycin resistance to Streptococcus agalactiae and Streptococcus anginosus. mBio. 2014 Jul 22;5(4):e01386-14. DMK7T1Q RU https://pubmed.ncbi.nlm.nih.gov/25053786 DMK7T1Q DI DMK7T1Q DMK7T1Q DN Vancomycin DMK7T1Q MI DEOFMQ7 DMK7T1Q MN VanA ligase (vanA) DMK7T1Q MT DME DMK7T1Q MA Metabolism DMK7T1Q RN Genetics and mechanisms of glycopeptide resistance in enterococci. Antimicrob Agents Chemother. 1993 Aug;37(8):1563-71. DMK7T1Q RU https://pubmed.ncbi.nlm.nih.gov/8215264 DMK7T1Q DI DMK7T1Q DMK7T1Q DN Vancomycin DMK7T1Q MI DEO97D6 DMK7T1Q MN VanA ligase (vanA) DMK7T1Q MT DME DMK7T1Q MA Metabolism DMK7T1Q RN Genetics and mechanisms of glycopeptide resistance in enterococci. Antimicrob Agents Chemother. 1993 Aug;37(8):1563-71. DMK7T1Q RU https://pubmed.ncbi.nlm.nih.gov/8215264 DMK7T1Q DI DMK7T1Q DMK7T1Q DN Vancomycin DMK7T1Q MI DEO8E75 DMK7T1Q MN VanA ligase (vanA) DMK7T1Q MT DME DMK7T1Q MA Metabolism DMK7T1Q RN Genetics and mechanisms of glycopeptide resistance in enterococci. Antimicrob Agents Chemother. 1993 Aug;37(8):1563-71. DMK7T1Q RU https://pubmed.ncbi.nlm.nih.gov/8215264 DMK7T1Q DI DMK7T1Q DMK7T1Q DN Vancomycin DMK7T1Q MI DEN6VO0 DMK7T1Q MN VanA ligase (vanA) DMK7T1Q MT DME DMK7T1Q MA Metabolism DMK7T1Q RN Emergence of high-level resistance to glycopeptides in Enterococcus gallinarum and Enterococcus casseliflavus. Antimicrob Agents Chemother. 1994 Jul;38(7):1675-7. DMK7T1Q RU https://pubmed.ncbi.nlm.nih.gov/7979308 DMK7T1Q DI DMK7T1Q DMK7T1Q DN Vancomycin DMK7T1Q MI DESOXHP DMK7T1Q MN VanA ligase (vanA) DMK7T1Q MT DME DMK7T1Q MA Metabolism DMK7T1Q RN nan DMK7T1Q RU nan DMK7T1Q DI DMK7T1Q DMK7T1Q DN Vancomycin DMK7T1Q MI DE27YVU DMK7T1Q MN VanB ligase (vanB) DMK7T1Q MT DME DMK7T1Q MA Metabolism DMK7T1Q RN Genetics and mechanisms of glycopeptide resistance in enterococci. Antimicrob Agents Chemother. 1993 Aug;37(8):1563-71. DMK7T1Q RU https://pubmed.ncbi.nlm.nih.gov/8215264 DMK7T1Q DI DMK7T1Q DMK7T1Q DN Vancomycin DMK7T1Q MI DER7KFQ DMK7T1Q MN VanB ligase (vanB) DMK7T1Q MT DME DMK7T1Q MA Metabolism DMK7T1Q RN Genetics and mechanisms of glycopeptide resistance in enterococci. Antimicrob Agents Chemother. 1993 Aug;37(8):1563-71. DMK7T1Q RU https://pubmed.ncbi.nlm.nih.gov/8215264 DMK7T1Q DI DMK7T1Q DMK7T1Q DN Vancomycin DMK7T1Q MI DEMDEJ8 DMK7T1Q MN VanB ligase (vanB) DMK7T1Q MT DME DMK7T1Q MA Metabolism DMK7T1Q RN vanI: a novel D-Ala-D-Lac vancomycin resistance gene cluster found in Desulfitobacterium hafniense. Microb Biotechnol. 2014 Sep;7(5):456-66. DMK7T1Q RU https://pubmed.ncbi.nlm.nih.gov/25042042 DMK7T1Q DI DMK7T1Q DMK7T1Q DN Vancomycin DMK7T1Q MI DE2GMEK DMK7T1Q MN VanB ligase (vanB) DMK7T1Q MT DME DMK7T1Q MA Metabolism DMK7T1Q RN vanI: a novel D-Ala-D-Lac vancomycin resistance gene cluster found in Desulfitobacterium hafniense. Microb Biotechnol. 2014 Sep;7(5):456-66. DMK7T1Q RU https://pubmed.ncbi.nlm.nih.gov/25042042 DMK7T1Q DI DMK7T1Q DMK7T1Q DN Vancomycin DMK7T1Q MI DEIF4P9 DMK7T1Q MN VanC2 ligase (vanC) DMK7T1Q MT DME DMK7T1Q MA Metabolism DMK7T1Q RN Sequence of the vanC gene of Enterococcus gallinarum BM4174 encoding a D-alanine:D-alanine ligase-related protein necessary for vancomycin resistance. Gene. 1992 Mar 1;112(1):53-8. DMK7T1Q RU https://pubmed.ncbi.nlm.nih.gov/1551598 DMK7T1Q DI DMK7T1Q DMK7T1Q DN Vancomycin DMK7T1Q MI DEH73ZC DMK7T1Q MN VanC2 ligase (vanC) DMK7T1Q MT DME DMK7T1Q MA Metabolism DMK7T1Q RN Bacterial resistance to vancomycin: overproduction, purification, and characterization of VanC2 from Enterococcus casseliflavus as a D-Ala-D-Ser ligase. Proc Natl Acad Sci U S A. 1997 Sep 16;94(19):10040-4. DMK7T1Q RU https://pubmed.ncbi.nlm.nih.gov/9294159 DMK7T1Q DI DMK7T1Q DMK7T1Q DN Vancomycin DMK7T1Q MI DEPH3S7 DMK7T1Q MN VanG ligase (vanG) DMK7T1Q MT DME DMK7T1Q MA Metabolism DMK7T1Q RN vanG element insertions within a conserved chromosomal site conferring vancomycin resistance to Streptococcus agalactiae and Streptococcus anginosus. mBio. 2014 Jul 22;5(4):e01386-14. DMK7T1Q RU https://pubmed.ncbi.nlm.nih.gov/25053786 DMK7T1Q DI DMK7T1Q DMK7T1Q DN Vancomycin DMK7T1Q MI DEPN8F9 DMK7T1Q MN VanG ligase (vanG) DMK7T1Q MT DME DMK7T1Q MA Metabolism DMK7T1Q RN vanG element insertions within a conserved chromosomal site conferring vancomycin resistance to Streptococcus agalactiae and Streptococcus anginosus. mBio. 2014 Jul 22;5(4):e01386-14. DMK7T1Q RU https://pubmed.ncbi.nlm.nih.gov/25053786 DMRICNP DI DMRICNP DMRICNP DN Vandetanib DMRICNP MI DTI7UX6 DMRICNP MN Breast cancer resistance protein (ABCG2) DMRICNP MT DTP DMRICNP MA Substrate DMRICNP RN Tyrosine kinase inhibitors and multidrug resistance proteins: interactions and biological consequences. Cancer Chemother Pharmacol. 2010 Jan;65(2):335-46. DMRICNP RU https://doi.org/10.1007/s00280-009-1039-0 DMRICNP DI DMRICNP DMRICNP DN Vandetanib DMRICNP MI DE4LYSA DMRICNP MN Cytochrome P450 3A4 (CYP3A4) DMRICNP MT DME DMRICNP MA Metabolism DMRICNP RN FDA label of Vandetanib. The 2020 official website of the U.S. Food and Drug Administration. DMRICNP RU http://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=d2a87691-c9ad-4753-97a1-311fccfe6515 DMRICNP DI DMRICNP DMRICNP DN Vandetanib DMRICNP MI TTGKNB4 DMRICNP MN Epidermal growth factor receptor (EGFR) DMRICNP MT DTT DMRICNP MA Inhibitor DMRICNP RN A comparison of physicochemical property profiles of marketed oral drugs and orally bioavailable anti-cancer protein kinase inhibitors in clinical development. Curr Top Med Chem. 2007;7(14):1408-22. DMRICNP RU https://pubmed.ncbi.nlm.nih.gov/17692029 DMRICNP DI DMRICNP DMRICNP DN Vandetanib DMRICNP MI DT3D8F0 DMRICNP MN Organic anion transporting polypeptide 1B1 (SLCO1B1) DMRICNP MT DTP DMRICNP MA Substrate DMRICNP RN Contribution of OATP1B1 and OATP1B3 to the disposition of sorafenib and sorafenib-glucuronide. Clin Cancer Res. 2013 Mar 15;19(6):1458-66. DMRICNP RU http://www.ncbi.nlm.nih.gov/pubmed/23340295 DMRICNP DI DMRICNP DMRICNP DN Vandetanib DMRICNP MI DT9C1TS DMRICNP MN Organic anion transporting polypeptide 1B3 (SLCO1B3) DMRICNP MT DTP DMRICNP MA Substrate DMRICNP RN Contribution of OATP1B1 and OATP1B3 to the disposition of sorafenib and sorafenib-glucuronide. Clin Cancer Res. 2013 Mar 15;19(6):1458-66. DMRICNP RU http://www.ncbi.nlm.nih.gov/pubmed/23340295 DMRICNP DI DMRICNP DMRICNP DN Vandetanib DMRICNP MI TT4DXQT DMRICNP MN Proto-oncogene c-Ret (RET) DMRICNP MT DTT DMRICNP MA Inhibitor DMRICNP RN A comparison of physicochemical property profiles of marketed oral drugs and orally bioavailable anti-cancer protein kinase inhibitors in clinical development. Curr Top Med Chem. 2007;7(14):1408-22. DMRICNP RU https://pubmed.ncbi.nlm.nih.gov/17692029 DMRICNP DI DMRICNP DMRICNP DN Vandetanib DMRICNP MI TTUTJGQ DMRICNP MN Vascular endothelial growth factor receptor 2 (KDR) DMRICNP MT DTT DMRICNP MA Inhibitor DMRICNP RN A comparison of physicochemical property profiles of marketed oral drugs and orally bioavailable anti-cancer protein kinase inhibitors in clinical development. Curr Top Med Chem. 2007;7(14):1408-22. DMRICNP RU https://pubmed.ncbi.nlm.nih.gov/17692029 DMTBGW8 DI DMTBGW8 DMTBGW8 DN Vardenafil DMTBGW8 MI DE4LYSA DMTBGW8 MN Cytochrome P450 3A4 (CYP3A4) DMTBGW8 MT DME DMTBGW8 MA Metabolism DMTBGW8 RN Erectile dysfunction drugs changed the protein expressions and activities of drug-metabolising enzymes in the liver of male rats. Oxid Med Cell Longev. 2016;2016:4970906. DMTBGW8 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=27800121 DMTBGW8 DI DMTBGW8 DMTBGW8 DN Vardenafil DMTBGW8 MI DEIBDNY DMTBGW8 MN Cytochrome P450 3A5 (CYP3A5) DMTBGW8 MT DME DMTBGW8 MA Metabolism DMTBGW8 RN The contributions of cytochromes P450 3A4 and 3A5 to the metabolism of the phosphodiesterase type 5 inhibitors sildenafil, udenafil, and vardenafil. Drug Metab Dispos. 2008 Jun;36(6):986-90. DMTBGW8 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=18308836 DMTBGW8 DI DMTBGW8 DMTBGW8 DN Vardenafil DMTBGW8 MI TTJ0IQB DMTBGW8 MN Phosphodiesterase 5A (PDE5A) DMTBGW8 MT DTT DMTBGW8 MA Binder DMTBGW8 RN The effect of vardenafil, a potent and highly selective phosphodiesterase-5 inhibitor for the treatment of erectile dysfunction, on the cardiovascular response to exercise in patients with coronary artery disease. J Am Coll Cardiol. 2002 Dec 4;40(11):2006-12. DMTBGW8 RU https://pubmed.ncbi.nlm.nih.gov/12475462 DMMUOLJ DI DMMUOLJ DMMUOLJ DN Varenicline DMMUOLJ MI TTL1ATN DMMUOLJ MN Neuronal acetylcholine receptor alpha-4/beta-2 (CHRNA4/B2) DMMUOLJ MT DTT DMMUOLJ MA Modulator DMMUOLJ RN 2006 drug approvals: finding the niche. Nat Rev Drug Discov. 2007 Feb;6(2):99-101. DMMUOLJ RU https://pubmed.ncbi.nlm.nih.gov/17342860 DMMUOLJ DI DMMUOLJ DMMUOLJ DN Varenicline DMMUOLJ MI DTT79CX DMMUOLJ MN Organic cation transporter 1 (SLC22A1) DMMUOLJ MT DTP DMMUOLJ MA Substrate DMMUOLJ RN Identification of novel substrates and structure-activity relationship of cellular uptake mediated by human organic cation transporters 1 and 2. J Med Chem. 2013 Sep 26;56(18):7232-42. DMMUOLJ RU http://www.ncbi.nlm.nih.gov/pubmed/23984907 DMMUOLJ DI DMMUOLJ DMMUOLJ DN Varenicline DMMUOLJ MI DT9IDPW DMMUOLJ MN Organic cation transporter 2 (SLC22A2) DMMUOLJ MT DTP DMMUOLJ MA Substrate DMMUOLJ RN Effect of human renal cationic transporter inhibition on the pharmacokinetics of varenicline, a new therapy for smoking cessation: an in vitro-in vivo study. Clin Pharmacol Ther. 2008 Apr;83(4):567-76. DMMUOLJ RU http://www.ncbi.nlm.nih.gov/pubmed/17971819 DMQ2FPC DI DMQ2FPC DMQ2FPC DN Vasopressin DMQ2FPC MI DTFI42L DMQ2FPC MN Multidrug resistance-associated protein 2 (ABCC2) DMQ2FPC MT DTP DMQ2FPC MA Substrate DMQ2FPC RN Transport function and hepatocellular localization of mrp6 in rat liver. Mol Pharmacol. 2000 Mar;57(3):634-41. DMQ2FPC RU http://www.ncbi.nlm.nih.gov/pubmed/10692506 DMQ2FPC DI DMQ2FPC DMQ2FPC DN Vasopressin DMQ2FPC MI TTK8R02 DMQ2FPC MN Vasopressin V2 receptor (V2R) DMQ2FPC MT DTT DMQ2FPC MA Agonist DMQ2FPC RN Vasopressin receptors: structure/function relationships and signal transduction in target cells. J Soc Biol. 2005;199(4):351-9. DMQ2FPC RU https://pubmed.ncbi.nlm.nih.gov/16738530 DMP0UK2 DI DMP0UK2 DMP0UK2 DN Vecuronium DMP0UK2 MI TTF4E0J DMP0UK2 MN Neuronal acetylcholine receptor alpha-2 (CHRNA2) DMP0UK2 MT DTT DMP0UK2 MA Antagonist DMP0UK2 RN Pharmacological characteristics of the inhibition of nondepolarizing neuromuscular blocking agents at human adult muscle nicotinic acetylcholine receptor. Anesthesiology. 2009 Jun;110(6):1244-52. DMP0UK2 RU https://pubmed.ncbi.nlm.nih.gov/19417616 DMP0UK2 DI DMP0UK2 DMP0UK2 DN Vecuronium DMP0UK2 MI DTUGYRD DMP0UK2 MN P-glycoprotein 1 (ABCB1) DMP0UK2 MT DTP DMP0UK2 MA Substrate DMP0UK2 RN Polymorphisms in human MDR1 (P-glycoprotein): recent advances and clinical relevance. Clin Pharmacol Ther. 2004 Jan;75(1):13-33. DMP0UK2 RU https://doi.org/10.1016/j.clpt.2003.09.012 DMV3YMX DI DMV3YMX DMV3YMX DN Vedolizmab DMV3YMX MI TT4BT06 DMV3YMX MN Integrin alpha-4 (ITGA4) DMV3YMX MT DTT DMV3YMX MA Antagonist DMV3YMX RN Clinical pipeline report, company report or official report of Takeda (2009). DMV3YMX RU http://www.takeda.com/pdf/usr/default/10_1_34992_2.pdf DMV3YMX DI DMV3YMX DMV3YMX DN Vedolizmab DMV3YMX MI TTLT9XQ DMV3YMX MN Integrin beta-7 (ITGB7) DMV3YMX MT DTT DMV3YMX MA Antagonist DMV3YMX RN Clinical pipeline report, company report or official report of Takeda (2009). DMV3YMX RU http://www.takeda.com/pdf/usr/default/10_1_34992_2.pdf DM4BOAS DI DM4BOAS DM4BOAS DN Velaglucerase alfa DM4BOAS MI TT1B5PU DM4BOAS MN Glucosylceramidase (GBA) DM4BOAS MT DTT DM4BOAS MA Modulator DM4BOAS RN Mullard A: 2010 FDA drug approvals. Nat Rev Drug Discov. 2011 Feb;10(2):82-5. DM4BOAS RU https://pubmed.ncbi.nlm.nih.gov/21283092 DMGF8ZQ DI DMGF8ZQ DMGF8ZQ DN Velpatasvir DMGF8ZQ MI DEPKLMQ DMGF8ZQ MN Cytochrome P450 2B6 (CYP2B6) DMGF8ZQ MT DME DMGF8ZQ MA Metabolism DMGF8ZQ RN Epclusa- European Medicines Agency - European Union DMGF8ZQ RU https://www.ema.europa.eu/en/documents/product-information/epclusa-epar-product-information_de.pdf DMGF8ZQ DI DMGF8ZQ DMGF8ZQ DN Velpatasvir DMGF8ZQ MI DES5XRU DMGF8ZQ MN Cytochrome P450 2C8 (CYP2C8) DMGF8ZQ MT DME DMGF8ZQ MA Metabolism DMGF8ZQ RN FDA Label of Vosevi. The 2020 official website of the U.S. Food and Drug Administration. DMGF8ZQ RU https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/209195s000lbl.pdf DMGF8ZQ DI DMGF8ZQ DMGF8ZQ DN Velpatasvir DMGF8ZQ MI DE4LYSA DMGF8ZQ MN Cytochrome P450 3A4 (CYP3A4) DMGF8ZQ MT DME DMGF8ZQ MA Metabolism DMGF8ZQ RN Product characteristics of Epclusa. DMGF8ZQ RU https://www.ema.europa.eu/en/documents/product-information/epclusa-epar-product-information_en.pdf DM62UG5 DI DM62UG5 DM62UG5 DN Vemurafenib DM62UG5 MI DE4LYSA DM62UG5 MN Cytochrome P450 3A4 (CYP3A4) DM62UG5 MT DME DM62UG5 MA Metabolism DM62UG5 RN Vemurafenib for the treatment of melanoma. Expert Opin Pharmacother. 2012 Dec;13(17):2533-43. DM62UG5 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=23094782 DM62UG5 DI DM62UG5 DM62UG5 DN Vemurafenib DM62UG5 MI DT3D8F0 DM62UG5 MN Organic anion transporting polypeptide 1B1 (SLCO1B1) DM62UG5 MT DTP DM62UG5 MA Substrate DM62UG5 RN Contribution of OATP1B1 and OATP1B3 to the disposition of sorafenib and sorafenib-glucuronide. Clin Cancer Res. 2013 Mar 15;19(6):1458-66. DM62UG5 RU http://www.ncbi.nlm.nih.gov/pubmed/23340295 DM62UG5 DI DM62UG5 DM62UG5 DN Vemurafenib DM62UG5 MI DT9C1TS DM62UG5 MN Organic anion transporting polypeptide 1B3 (SLCO1B3) DM62UG5 MT DTP DM62UG5 MA Substrate DM62UG5 RN Contribution of OATP1B1 and OATP1B3 to the disposition of sorafenib and sorafenib-glucuronide. Clin Cancer Res. 2013 Mar 15;19(6):1458-66. DM62UG5 RU http://www.ncbi.nlm.nih.gov/pubmed/23340295 DM62UG5 DI DM62UG5 DM62UG5 DN Vemurafenib DM62UG5 MI DTUGYRD DM62UG5 MN P-glycoprotein 1 (ABCB1) DM62UG5 MT DTP DM62UG5 MA Substrate DM62UG5 RN Differential effects of the oncogenic BRAF inhibitor PLX4032 (vemurafenib) and its progenitor PLX4720 on ABCB1 function. J Pharm Pharm Sci. 2014;17(1):154-68. DM62UG5 RU http://www.ncbi.nlm.nih.gov/pubmed/24735766 DM62UG5 DI DM62UG5 DM62UG5 DN Vemurafenib DM62UG5 MI TTWCGQT DM62UG5 MN Serine/threonine-protein kinase B-raf (BRAF) DM62UG5 MT DTT DM62UG5 MA Modulator DM62UG5 RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015 DM62UG5 RU https://www.accessdata.fda.gov/scripts/cder/drugsatfda/ DM8I94Y DI DM8I94Y DM8I94Y DN Venetoclax DM8I94Y MI DTUGYRD DM8I94Y MN P-glycoprotein 1 (ABCB1) DM8I94Y MT DTP DM8I94Y MA Substrate DM8I94Y RN Venclexta FDA label DM8I94Y RU https://s3-us-west-2.amazonaws.com/drugbank/cite_this/attachments/files/000/002/127/original/Venclexta_FDA_label.pdf?1543869212 DMR6QH0 DI DMR6QH0 DMR6QH0 DN Venlafaxine DMR6QH0 MI DE5IED8 DMR6QH0 MN Cytochrome P450 2C9 (CYP2C9) DMR6QH0 MT DME DMR6QH0 MA Metabolism DMR6QH0 RN O- and N-demethylation of venlafaxine in vitro by human liver microsomes and by microsomes from cDNA-transfected cells: effect of metabolic inhibitors and SSRI antidepressants. Neuropsychopharmacology. 1999 May;20(5):480-90. DMR6QH0 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=10192828 DMR6QH0 DI DMR6QH0 DMR6QH0 DN Venlafaxine DMR6QH0 MI DECB0K3 DMR6QH0 MN Cytochrome P450 2D6 (CYP2D6) DMR6QH0 MT DME DMR6QH0 MA Metabolism DMR6QH0 RN The associations between CYP2D6 metabolizer status and pharmacokinetics and clinical outcomes of venlafaxine: a systematic review and meta-analysis. Pharmacopsychiatry. 2019 Sep;52(5):222-231. DMR6QH0 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=30485867 DMR6QH0 DI DMR6QH0 DMR6QH0 DN Venlafaxine DMR6QH0 MI DE4LYSA DMR6QH0 MN Cytochrome P450 3A4 (CYP3A4) DMR6QH0 MT DME DMR6QH0 MA Metabolism DMR6QH0 RN Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. DMR6QH0 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=19515014 DMR6QH0 DI DMR6QH0 DMR6QH0 DN Venlafaxine DMR6QH0 MI DEGTFWK DMR6QH0 MN Mephenytoin 4-hydroxylase (CYP2C19) DMR6QH0 MT DME DMR6QH0 MA Metabolism DMR6QH0 RN O- and N-demethylation of venlafaxine in vitro by human liver microsomes and by microsomes from cDNA-transfected cells: effect of metabolic inhibitors and SSRI antidepressants. Neuropsychopharmacology. 1999 May;20(5):480-90. DMR6QH0 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=10192828 DMR6QH0 DI DMR6QH0 DMR6QH0 DN Venlafaxine DMR6QH0 MI TTAWNKZ DMR6QH0 MN Norepinephrine transporter (NET) DMR6QH0 MT DTT DMR6QH0 MA Inhibitor DMR6QH0 RN Clinically relevant drug interactions with new generation antidepressants and antipsychotics. Ther Umsch. 2009 Jun;66(6):485-92. DMR6QH0 RU https://pubmed.ncbi.nlm.nih.gov/19496045 DMR6QH0 DI DMR6QH0 DMR6QH0 DN Venlafaxine DMR6QH0 MI TT3ROYC DMR6QH0 MN Serotonin transporter (SERT) DMR6QH0 MT DTT DMR6QH0 MA Inhibitor DMR6QH0 RN Clinically relevant drug interactions with new generation antidepressants and antipsychotics. Ther Umsch. 2009 Jun;66(6):485-92. DMR6QH0 RU https://pubmed.ncbi.nlm.nih.gov/19496045 DMA7PEW DI DMA7PEW DMA7PEW DN Verapamil DMA7PEW MI DEJGDUW DMA7PEW MN Cytochrome P450 1A2 (CYP1A2) DMA7PEW MT DME DMA7PEW MA Metabolism DMA7PEW RN Identification of P450 enzymes involved in metabolism of verapamil in humans. Naunyn Schmiedebergs Arch Pharmacol. 1993 Sep;348(3):332-7. DMA7PEW RU https://www.ncbi.nlm.nih.gov/pubmed/?term=8232610 DMA7PEW DI DMA7PEW DMA7PEW DN Verapamil DMA7PEW MI DEPKLMQ DMA7PEW MN Cytochrome P450 2B6 (CYP2B6) DMA7PEW MT DME DMA7PEW MA Metabolism DMA7PEW RN Summary of information on human CYP enzymes: human P450 metabolism data. Drug Metab Rev. 2002 Feb-May;34(1-2):83-448. DMA7PEW RU https://www.ncbi.nlm.nih.gov/pubmed/?term=11996015 DMA7PEW DI DMA7PEW DMA7PEW DN Verapamil DMA7PEW MI DEZMWRE DMA7PEW MN Cytochrome P450 2C18 (CYP2C18) DMA7PEW MT DME DMA7PEW MA Metabolism DMA7PEW RN Summary of information on human CYP enzymes: human P450 metabolism data. Drug Metab Rev. 2002 Feb-May;34(1-2):83-448. DMA7PEW RU https://www.ncbi.nlm.nih.gov/pubmed/?term=11996015 DMA7PEW DI DMA7PEW DMA7PEW DN Verapamil DMA7PEW MI DES5XRU DMA7PEW MN Cytochrome P450 2C8 (CYP2C8) DMA7PEW MT DME DMA7PEW MA Metabolism DMA7PEW RN Differential expression and function of CYP2C isoforms in human intestine and liver. Pharmacogenetics. 2003 Sep;13(9):565-75. DMA7PEW RU https://www.ncbi.nlm.nih.gov/pubmed/?term=12972955 DMA7PEW DI DMA7PEW DMA7PEW DN Verapamil DMA7PEW MI DE5IED8 DMA7PEW MN Cytochrome P450 2C9 (CYP2C9) DMA7PEW MT DME DMA7PEW MA Metabolism DMA7PEW RN Drug interactions with calcium channel blockers: possible involvement of metabolite-intermediate complexation with CYP3A. Drug Metab Dispos. 2000 Feb;28(2):125-30. DMA7PEW RU https://www.ncbi.nlm.nih.gov/pubmed/?term=10640508 DMA7PEW DI DMA7PEW DMA7PEW DN Verapamil DMA7PEW MI DEVDYN7 DMA7PEW MN Cytochrome P450 2E1 (CYP2E1) DMA7PEW MT DME DMA7PEW MA Metabolism DMA7PEW RN Summary of information on human CYP enzymes: human P450 metabolism data. Drug Metab Rev. 2002 Feb-May;34(1-2):83-448. DMA7PEW RU https://www.ncbi.nlm.nih.gov/pubmed/?term=11996015 DMA7PEW DI DMA7PEW DMA7PEW DN Verapamil DMA7PEW MI DE4LYSA DMA7PEW MN Cytochrome P450 3A4 (CYP3A4) DMA7PEW MT DME DMA7PEW MA Metabolism DMA7PEW RN Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. DMA7PEW RU https://www.ncbi.nlm.nih.gov/pubmed/?term=19515014 DMA7PEW DI DMA7PEW DMA7PEW DN Verapamil DMA7PEW MI DEIBDNY DMA7PEW MN Cytochrome P450 3A5 (CYP3A5) DMA7PEW MT DME DMA7PEW MA Metabolism DMA7PEW RN Differential mechanism-based inhibition of CYP3A4 and CYP3A5 by verapamil. Drug Metab Dispos. 2005 May;33(5):664-71. DMA7PEW RU https://www.ncbi.nlm.nih.gov/pubmed/?term=15689501 DMA7PEW DI DMA7PEW DMA7PEW DN Verapamil DMA7PEW MI DERD86B DMA7PEW MN Cytochrome P450 3A7 (CYP3A7) DMA7PEW MT DME DMA7PEW MA Metabolism DMA7PEW RN Prediction of cytochrome P450 3A inhibition by verapamil enantiomers and their metabolites. Drug Metab Dispos. 2004 Feb;32(2):259-66. DMA7PEW RU https://www.ncbi.nlm.nih.gov/pubmed/?term=14744949 DMA7PEW DI DMA7PEW DMA7PEW DN Verapamil DMA7PEW MI DEGTFWK DMA7PEW MN Mephenytoin 4-hydroxylase (CYP2C19) DMA7PEW MT DME DMA7PEW MA Metabolism DMA7PEW RN Cytochromes of the P450 2C subfamily are the major enzymes involved in the O-demethylation of verapamil in humans. Naunyn Schmiedebergs Arch Pharmacol. 1995 Dec;353(1):116-21. DMA7PEW RU https://www.ncbi.nlm.nih.gov/pubmed/?term=8750925 DMA7PEW DI DMA7PEW DMA7PEW DN Verapamil DMA7PEW MI DTZRMK5 DMA7PEW MN Multidrug resistance protein 3 (ABCB4) DMA7PEW MT DTP DMA7PEW MA Substrate DMA7PEW RN MDR3 P-glycoprotein, a phosphatidylcholine translocase, transports several cytotoxic drugs and directly interacts with drugs as judged by interference with nucleotide trapping. J Biol Chem. 2000 Aug 4;275(31):23530-9. DMA7PEW RU http://www.ncbi.nlm.nih.gov/pubmed/10918072 DMA7PEW DI DMA7PEW DMA7PEW DN Verapamil DMA7PEW MI DTSYQGK DMA7PEW MN Multidrug resistance-associated protein 1 (ABCC1) DMA7PEW MT DTP DMA7PEW MA Substrate DMA7PEW RN Human intestinal transporter database: QSAR modeling and virtual profiling of drug uptake, efflux and interactions. Pharm Res. 2013 Apr;30(4):996-1007. DMA7PEW RU https://doi.org/10.1007/s11095-012-0935-x DMA7PEW DI DMA7PEW DMA7PEW DN Verapamil DMA7PEW MI DTT79CX DMA7PEW MN Organic cation transporter 1 (SLC22A1) DMA7PEW MT DTP DMA7PEW MA Substrate DMA7PEW RN Implications of genetic polymorphisms in drug transporters for pharmacotherapy. Cancer Lett. 2006 Mar 8;234(1):4-33. DMA7PEW RU https://doi.org/10.1016/j.canlet.2005.06.051 DMA7PEW DI DMA7PEW DMA7PEW DN Verapamil DMA7PEW MI DT2EG60 DMA7PEW MN Organic cation/carnitine transporter 1 (SLC22A4) DMA7PEW MT DTP DMA7PEW MA Substrate DMA7PEW RN Novel membrane transporter OCTN1 mediates multispecific, bidirectional, and pH-dependent transport of organic cations. J Pharmacol Exp Ther. 1999 May;289(2):768-73. DMA7PEW RU http://www.ncbi.nlm.nih.gov/pubmed/10215651 DMA7PEW DI DMA7PEW DMA7PEW DN Verapamil DMA7PEW MI DT3HUVD DMA7PEW MN Organic cation/carnitine transporter 2 (SLC22A5) DMA7PEW MT DTP DMA7PEW MA Substrate DMA7PEW RN Genetic variations of the SLC22A5 gene in the Chinese and Indian populations of Singapore. Drug Metab Pharmacokinet. 2010;25(1):112-9. DMA7PEW RU http://www.ncbi.nlm.nih.gov/pubmed/20208395 DMA7PEW DI DMA7PEW DMA7PEW DN Verapamil DMA7PEW MI DTUGYRD DMA7PEW MN P-glycoprotein 1 (ABCB1) DMA7PEW MT DTP DMA7PEW MA Substrate DMA7PEW RN Improved expression and purification of human multidrug resistance protein MDR1 from baculovirus-infected insect cells. Protein Expr Purif. 2009 Jul;66(1):7-14. DMA7PEW RU http://www.ncbi.nlm.nih.gov/pubmed/19233288 DMA7PEW DI DMA7PEW DMA7PEW DN Verapamil DMA7PEW MI TT729IR DMA7PEW MN Voltage-gated calcium channel alpha Cav3.1 (CACNA1G) DMA7PEW MT DTT DMA7PEW MA Blocker DMA7PEW RN Mechanism of tissue-selective drug action in the cardiovascular system. Mol Interv. 2005 Apr;5(2):84-93. DMA7PEW RU https://pubmed.ncbi.nlm.nih.gov/15821157 DM7MDBE DI DM7MDBE DM7MDBE DN Vericiguat DM7MDBE MI TTWNFC2 DM7MDBE MN Soluble guanylyl cyclase (GUCY2D) DM7MDBE MT DTT DM7MDBE MA Modulator DM7MDBE RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health Human Services. 2021 DM7MDBE RU https://www.accessdata.fda.gov/drugsatfda_docs/label/2021/214377s000lbl.pdf DMIY6DB DI DMIY6DB DMIY6DB DN Verteporfin DMIY6DB MI DTF9Y2V DMIY6DB MN ATP-binding cassette sub-family B member 6 (ABCB6) DMIY6DB MT DTP DMIY6DB MA Substrate DMIY6DB RN Efficient purification and reconstitution of ATP binding cassette transporter B6 (ABCB6) for functional and structural studies. J Biol Chem. 2013 Aug 2;288(31):22658-69. DMIY6DB RU http://www.ncbi.nlm.nih.gov/pubmed/23792964 DMIY6DB DI DMIY6DB DMIY6DB DN Verteporfin DMIY6DB MI DTI7UX6 DMIY6DB MN Breast cancer resistance protein (ABCG2) DMIY6DB MT DTP DMIY6DB MA Substrate DMIY6DB RN The tyrosine kinase inhibitor imatinib mesylate enhances the efficacy of photodynamic therapy by inhibiting ABCG2. Clin Cancer Res. 2007 Apr 15;13(8):2463-70. DMIY6DB RU https://doi.org/10.1158/1078-0432.CCR-06-1599 DMBKX3C DI DMBKX3C DMBKX3C DN VESNARINONE DMBKX3C MI TT06AWU DMBKX3C MN Phosphodiesterase 3A (PDE3A) DMBKX3C MT DTT DMBKX3C MA Inhibitor DMBKX3C RN Design, synthesis and biological evaluation of 6-(benzyloxy)-4-methylquinolin-2(1H)-one derivatives as PDE3 inhibitors. Bioorg Med Chem. 2010 Jan 15;18(2):855-62. DMBKX3C RU https://pubmed.ncbi.nlm.nih.gov/20005117 DMBKX3C DI DMBKX3C DMBKX3C DN VESNARINONE DMBKX3C MI TTQ6VDM DMBKX3C MN Voltage-gated potassium channel Kv11.1 (KCNH2) DMBKX3C MT DTT DMBKX3C MA Inhibitor DMBKX3C RN Prediction of hERG potassium channel affinity by traditional and hologram qSAR methods. Bioorg Med Chem Lett. 2003 Aug 18;13(16):2773-5. DMBKX3C RU https://pubmed.ncbi.nlm.nih.gov/12873512 DM4UHZF DI DM4UHZF DM4UHZF DN Vestronidase alfa DM4UHZF MI TTHS7CM DM4UHZF MN Beta-glucuronidase (GUSB) DM4UHZF MT DTT DM4UHZF MA Modulator DM4UHZF RN 2017 FDA drug approvals.Nat Rev Drug Discov. 2018 Feb;17(2):81-85. DM4UHZF RU https://pubmed.ncbi.nlm.nih.gov/29348678 DMFR201 DI DMFR201 DMFR201 DN Vibegron DMFR201 MI TTMXGCW DMFR201 MN Adrenergic receptor beta-3 (ADRB3) DMFR201 MT DTT DMFR201 MA Agonist DMFR201 RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health Human Services. 2020 DMFR201 RU https://www.accessdata.fda.gov/drugsatfda_docs/label/2020/213006s000lbl.pdf DM0N85H DI DM0N85H DM0N85H DN Vidarabine DM0N85H MI TTNE7KG DM0N85H MN Adenosine A2b receptor (ADORA2B) DM0N85H MT DTT DM0N85H MA Modulator DM0N85H RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. DM0N85H RU https://www.fda.gov/ DMYT0OG DI DMYT0OG DMYT0OG DN Vigabatrin DMYT0OG MI TTT2LD9 DMYT0OG MN GABA transaminase (ABAT) DMYT0OG MT DTT DMYT0OG MA Inhibitor DMYT0OG RN Hughes B: 2009 FDA drug approvals. Nat Rev Drug Discov. 2010 Feb;9(2):89-92. DMYT0OG RU https://pubmed.ncbi.nlm.nih.gov/20118952 DMYT0OG DI DMYT0OG DMYT0OG DN Vigabatrin DMYT0OG MI DT48WEM DMYT0OG MN Proton-coupled amino acid transporter 1 (SLC36A1) DMYT0OG MT DTP DMYT0OG MA Substrate DMYT0OG RN Rectal absorption of vigabatrin, a substrate of the proton coupled amino acid transporter (PAT1, Slc36a1), in rats. Pharm Res. 2012 Apr;29(4):1134-42. DMYT0OG RU http://www.ncbi.nlm.nih.gov/pubmed/22234618 DMF5EK1 DI DMF5EK1 DMF5EK1 DN Vilanterol DMF5EK1 MI TT2CJVK DMF5EK1 MN Adrenergic receptor beta-2 (ADRB2) DMF5EK1 MT DTT DMF5EK1 MA Modulator DMF5EK1 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7353). DMF5EK1 RU http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=7353 DMF5EK1 DI DMF5EK1 DMF5EK1 DN Vilanterol DMF5EK1 MI DE4LYSA DMF5EK1 MN Cytochrome P450 3A4 (CYP3A4) DMF5EK1 MT DME DMF5EK1 MA Metabolism DMF5EK1 RN The effect of ketoconazole on the pharmacokinetics and pharmacodynamics of inhaled fluticasone furoate and vilanterol trifenatate in healthy subjects. Br J Clin Pharmacol. 2013 Jun;75(6):1478-87. DMF5EK1 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=23116485 DM4LECQ DI DM4LECQ DM4LECQ DN Vilazodone DM4LECQ MI TTSQIFT DM4LECQ MN 5-HT 1A receptor (HTR1A) DM4LECQ MT DTT DM4LECQ MA Modulator DM4LECQ RN 2011 FDA drug approvals. Nat Rev Drug Discov. 2012 Feb 1;11(2):91-4. DM4LECQ RU https://pubmed.ncbi.nlm.nih.gov/22293555 DM4LECQ DI DM4LECQ DM4LECQ DN Vilazodone DM4LECQ MI DECB0K3 DM4LECQ MN Cytochrome P450 2D6 (CYP2D6) DM4LECQ MT DME DM4LECQ MA Metabolism DM4LECQ RN Vilazodone HCl (Viibryd): A Serotonin Partial Agonist and Reuptake Inhibitor For the Treatment of Major Depressive Disorder. P T. 2012 Jan;37(1):28-31. DM4LECQ RU https://www.ncbi.nlm.nih.gov/pubmed/?term=22346333 DM4LECQ DI DM4LECQ DM4LECQ DN Vilazodone DM4LECQ MI DE4LYSA DM4LECQ MN Cytochrome P450 3A4 (CYP3A4) DM4LECQ MT DME DM4LECQ MA Metabolism DM4LECQ RN Vilazodone HCl (Viibryd): A Serotonin Partial Agonist and Reuptake Inhibitor For the Treatment of Major Depressive Disorder. P T. 2012 Jan;37(1):28-31. DM4LECQ RU https://www.ncbi.nlm.nih.gov/pubmed/?term=22346333 DM4LECQ DI DM4LECQ DM4LECQ DN Vilazodone DM4LECQ MI DEGTFWK DM4LECQ MN Mephenytoin 4-hydroxylase (CYP2C19) DM4LECQ MT DME DM4LECQ MA Metabolism DM4LECQ RN Vilazodone HCl (Viibryd): A Serotonin Partial Agonist and Reuptake Inhibitor For the Treatment of Major Depressive Disorder. P T. 2012 Jan;37(1):28-31. DM4LECQ RU https://www.ncbi.nlm.nih.gov/pubmed/?term=22346333 DM4LECQ DI DM4LECQ DM4LECQ DN Vilazodone DM4LECQ MI TT3ROYC DM4LECQ MN Serotonin transporter (SERT) DM4LECQ MT DTT DM4LECQ MA Modulator DM4LECQ RN 2011 FDA drug approvals. Nat Rev Drug Discov. 2012 Feb 1;11(2):91-4. DM4LECQ RU https://pubmed.ncbi.nlm.nih.gov/22293555 DMYN59P DI DMYN59P DMYN59P DN Vildagliptin DMYN59P MI TTDIGC1 DMYN59P MN Dipeptidyl peptidase 4 (DPP-4) DMYN59P MT DTT DMYN59P MA Inhibitor DMYN59P RN Emerging drug candidates of dipeptidyl peptidase IV (DPP IV) inhibitor class for the treatment of Type 2 Diabetes. Curr Drug Targets. 2009 Jan;10(1):71-87. DMYN59P RU https://pubmed.ncbi.nlm.nih.gov/19149538 DMYN59P DI DMYN59P DMYN59P DN Vildagliptin DMYN59P MI DTUGYRD DMYN59P MN P-glycoprotein 1 (ABCB1) DMYN59P MT DTP DMYN59P MA Substrate DMYN59P RN Pharmacokinetics of dipeptidylpeptidase-4 inhibitors. Diabetes Obes Metab. 2010 Aug;12(8):648-58. DMYN59P RU https://doi.org/10.1111/j.1463-1326.2010.01212.x DM5TVS3 DI DM5TVS3 DM5TVS3 DN Vinblastine DM5TVS3 MI DTI7UX6 DM5TVS3 MN Breast cancer resistance protein (ABCG2) DM5TVS3 MT DTP DM5TVS3 MA Substrate DM5TVS3 RN Ixabepilone, a novel microtubule-targeting agent for breast cancer, is a substrate for P-glycoprotein (P-gp/MDR1/ABCB1) but not breast cancer resistance protein (BCRP/ABCG2). J Pharmacol Exp Ther. 2011 May;337(2):423-32. DM5TVS3 RU http://www.ncbi.nlm.nih.gov/pubmed/21262849 DM5TVS3 DI DM5TVS3 DM5TVS3 DN Vinblastine DM5TVS3 MI DECB0K3 DM5TVS3 MN Cytochrome P450 2D6 (CYP2D6) DM5TVS3 MT DME DM5TVS3 MA Metabolism DM5TVS3 RN Inhibitory effects of anticancer drugs on dextromethorphan-O-demethylase activity in human liver microsomes. Cancer Chemother Pharmacol. 1993;32(6):491-5. DM5TVS3 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=8258200 DM5TVS3 DI DM5TVS3 DM5TVS3 DN Vinblastine DM5TVS3 MI DE4LYSA DM5TVS3 MN Cytochrome P450 3A4 (CYP3A4) DM5TVS3 MT DME DM5TVS3 MA Metabolism DM5TVS3 RN Induction of CYP3A4 by vinblastine: role of the nuclear receptor NR1I2. Ann Pharmacother. 2010 Nov;44(11):1709-17. DM5TVS3 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=20959500 DM5TVS3 DI DM5TVS3 DM5TVS3 DN Vinblastine DM5TVS3 MI DEIBDNY DM5TVS3 MN Cytochrome P450 3A5 (CYP3A5) DM5TVS3 MT DME DM5TVS3 MA Metabolism DM5TVS3 RN Drug related genetic polymorphisms affecting adverse reactions to methotrexate, vinblastine, doxorubicin and cisplatin in patients with urothelial cancer. J Urol. 2008 Dec;180(6):2389-95. DM5TVS3 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=18930278 DM5TVS3 DI DM5TVS3 DM5TVS3 DN Vinblastine DM5TVS3 MI DTZRMK5 DM5TVS3 MN Multidrug resistance protein 3 (ABCB4) DM5TVS3 MT DTP DM5TVS3 MA Substrate DM5TVS3 RN MDR3 P-glycoprotein, a phosphatidylcholine translocase, transports several cytotoxic drugs and directly interacts with drugs as judged by interference with nucleotide trapping. J Biol Chem. 2000 Aug 4;275(31):23530-9. DM5TVS3 RU http://www.ncbi.nlm.nih.gov/pubmed/10918072 DM5TVS3 DI DM5TVS3 DM5TVS3 DN Vinblastine DM5TVS3 MI DTSYQGK DM5TVS3 MN Multidrug resistance-associated protein 1 (ABCC1) DM5TVS3 MT DTP DM5TVS3 MA Substrate DM5TVS3 RN Development and characterization of a recombinant Madin-Darby canine kidney cell line that expresses rat multidrug resistance-associated protein 1 (rMRP1). AAPS PharmSci. 2004 Mar 9;6(1):E8. DM5TVS3 RU http://www.ncbi.nlm.nih.gov/pubmed/15198509 DM5TVS3 DI DM5TVS3 DM5TVS3 DN Vinblastine DM5TVS3 MI DTFI42L DM5TVS3 MN Multidrug resistance-associated protein 2 (ABCC2) DM5TVS3 MT DTP DM5TVS3 MA Substrate DM5TVS3 RN Severe hypokalemia due to a possible drug-drug interaction between vinblastine and antiretrovirals in a HIV-infected patient with Hodgkin's lymphoma. Int J STD AIDS. 2017 Oct;28(12):1259-1262. DM5TVS3 RU http://www.ncbi.nlm.nih.gov/pubmed/28403692 DM5TVS3 DI DM5TVS3 DM5TVS3 DN Vinblastine DM5TVS3 MI DTUGYRD DM5TVS3 MN P-glycoprotein 1 (ABCB1) DM5TVS3 MT DTP DM5TVS3 MA Substrate DM5TVS3 RN Xenopus laevis oocytes expressing human P-glycoprotein: probing trans- and cis-inhibitory effects on [3H]vinblastine and [3H]digoxin efflux. Pharmacol Res. 2010 Jan;61(1):76-84. DM5TVS3 RU http://www.ncbi.nlm.nih.gov/pubmed/19631272 DM5TVS3 DI DM5TVS3 DM5TVS3 DN Vinblastine DM5TVS3 MI TTJ2PTI DM5TVS3 MN Tubulin beta-2 chain (TUBB2) DM5TVS3 MT DTT DM5TVS3 MA Inhibitor DM5TVS3 RN Effect of the antitumor drug vinblastine on nuclear betaII-tubulin in cultured rat kidney mesangial cells. Invest New Drugs. 2003 Feb;21(1):15-20. DM5TVS3 RU https://pubmed.ncbi.nlm.nih.gov/12795526 DMK1ZOR DI DMK1ZOR DMK1ZOR DN Vincamine DMK1ZOR MI DEJGDUW DMK1ZOR MN Cytochrome P450 1A2 (CYP1A2) DMK1ZOR MT DME DMK1ZOR MA Metabolism DMK1ZOR RN Characterization of human cytochrome P450 isoenzymes involved in the metabolism of vinorelbine. Fundam Clin Pharmacol. 2005 Oct;19(5):545-53. DMK1ZOR RU https://www.ncbi.nlm.nih.gov/pubmed/?term=16176333 DMK1ZOR DI DMK1ZOR DMK1ZOR DN Vincamine DMK1ZOR MI DECB0K3 DMK1ZOR MN Cytochrome P450 2D6 (CYP2D6) DMK1ZOR MT DME DMK1ZOR MA Metabolism DMK1ZOR RN Characterization of human cytochrome P450 isoenzymes involved in the metabolism of vinorelbine. Fundam Clin Pharmacol. 2005 Oct;19(5):545-53. DMK1ZOR RU https://www.ncbi.nlm.nih.gov/pubmed/?term=16176333 DMK1ZOR DI DMK1ZOR DMK1ZOR DN Vincamine DMK1ZOR MI DEVDYN7 DMK1ZOR MN Cytochrome P450 2E1 (CYP2E1) DMK1ZOR MT DME DMK1ZOR MA Metabolism DMK1ZOR RN Characterization of human cytochrome P450 isoenzymes involved in the metabolism of vinorelbine. Fundam Clin Pharmacol. 2005 Oct;19(5):545-53. DMK1ZOR RU https://www.ncbi.nlm.nih.gov/pubmed/?term=16176333 DMK1ZOR DI DMK1ZOR DMK1ZOR DN Vincamine DMK1ZOR MI DE4LYSA DMK1ZOR MN Cytochrome P450 3A4 (CYP3A4) DMK1ZOR MT DME DMK1ZOR MA Metabolism DMK1ZOR RN Characterization of human cytochrome P450 isoenzymes involved in the metabolism of vinorelbine. Fundam Clin Pharmacol. 2005 Oct;19(5):545-53. DMK1ZOR RU https://www.ncbi.nlm.nih.gov/pubmed/?term=16176333 DMINOX3 DI DMINOX3 DMINOX3 DN Vincristine DMINOX3 MI DTI7UX6 DMINOX3 MN Breast cancer resistance protein (ABCG2) DMINOX3 MT DTP DMINOX3 MA Substrate DMINOX3 RN Mutant Gly482 and Thr482 ABCG2 mediate high-level resistance to lipophilic antifolates. Cancer Chemother Pharmacol. 2006 Dec;58(6):826-34. DMINOX3 RU https://doi.org/10.1007/s00280-006-0230-9 DMINOX3 DI DMINOX3 DMINOX3 DN Vincristine DMINOX3 MI DE4LYSA DMINOX3 MN Cytochrome P450 3A4 (CYP3A4) DMINOX3 MT DME DMINOX3 MA Metabolism DMINOX3 RN Association of CYP3A5 expression and vincristine neurotoxicity in pediatric malignancies in Turkish population. J Pediatr Hematol Oncol. 2017 Aug;39(6):458-462. DMINOX3 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=28697165 DMINOX3 DI DMINOX3 DMINOX3 DN Vincristine DMINOX3 MI DEIBDNY DMINOX3 MN Cytochrome P450 3A5 (CYP3A5) DMINOX3 MT DME DMINOX3 MA Metabolism DMINOX3 RN Association of CYP3A5 expression and vincristine neurotoxicity in pediatric malignancies in Turkish population. J Pediatr Hematol Oncol. 2017 Aug;39(6):458-462. DMINOX3 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=28697165 DMINOX3 DI DMINOX3 DMINOX3 DN Vincristine DMINOX3 MI DERD86B DMINOX3 MN Cytochrome P450 3A7 (CYP3A7) DMINOX3 MT DME DMINOX3 MA Metabolism DMINOX3 RN Drug Interactions Flockhart Table DMINOX3 RU https://drug-interactions.medicine.iu.edu/Main-Table.aspx DMINOX3 DI DMINOX3 DMINOX3 DN Vincristine DMINOX3 MI DTSYQGK DMINOX3 MN Multidrug resistance-associated protein 1 (ABCC1) DMINOX3 MT DTP DMINOX3 MA Substrate DMINOX3 RN Interaction of plant cannabinoids with the multidrug transporter ABCC1 (MRP1). Eur J Pharmacol. 2008 Sep 4;591(1-3):128-31. DMINOX3 RU http://www.ncbi.nlm.nih.gov/pubmed/18619955 DMINOX3 DI DMINOX3 DMINOX3 DN Vincristine DMINOX3 MI DTFI42L DMINOX3 MN Multidrug resistance-associated protein 2 (ABCC2) DMINOX3 MT DTP DMINOX3 MA Substrate DMINOX3 RN Mammalian drug efflux transporters of the ATP binding cassette (ABC) family in multidrug resistance: A review of the past decade. Cancer Lett. 2016 Jan 1;370(1):153-64. DMINOX3 RU http://www.ncbi.nlm.nih.gov/pubmed/26499806 DMINOX3 DI DMINOX3 DMINOX3 DN Vincristine DMINOX3 MI DTUGYRD DMINOX3 MN P-glycoprotein 1 (ABCB1) DMINOX3 MT DTP DMINOX3 MA Substrate DMINOX3 RN L-type calcium channel blockers reverse docetaxel and vincristine-induced multidrug resistance independent of ABCB1 expression in human lung cancer cell lines. Toxicol Lett. 2010 Feb 15;192(3):408-18. DMINOX3 RU http://www.ncbi.nlm.nih.gov/pubmed/19944135 DMINOX3 DI DMINOX3 DMINOX3 DN Vincristine DMINOX3 MI TTYFKSZ DMINOX3 MN Tubulin beta (TUBB) DMINOX3 MT DTT DMINOX3 MA Modulator DMINOX3 RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. DMINOX3 RU https://www.fda.gov/ DMVR628 DI DMVR628 DMVR628 DN Vindesine DMVR628 MI DE4LYSA DMVR628 MN Cytochrome P450 3A4 (CYP3A4) DMVR628 MT DME DMVR628 MA Metabolism DMVR628 RN Human liver microsomal cytochrome P450 3A isozymes mediated vindesine biotransformation. Metabolic drug interactions. Biochem Pharmacol. 1993 Feb 24;45(4):853-61. DMVR628 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=8452560 DMVR628 DI DMVR628 DMVR628 DN Vindesine DMVR628 MI DEIBDNY DMVR628 MN Cytochrome P450 3A5 (CYP3A5) DMVR628 MT DME DMVR628 MA Metabolism DMVR628 RN Structural perspectives of the CYP3A family and their small molecule modulators in drug metabolism. 2019, 3(3), 132-142. DMVR628 RU https://www.sciencedirect.com/science/article/pii/S2542568419300431 DMVR628 DI DMVR628 DMVR628 DN Vindesine DMVR628 MI DERD86B DMVR628 MN Cytochrome P450 3A7 (CYP3A7) DMVR628 MT DME DMVR628 MA Metabolism DMVR628 RN Structural perspectives of the CYP3A family and their small molecule modulators in drug metabolism. 2019, 3(3), 132-142. DMVR628 RU https://www.sciencedirect.com/science/article/pii/S2542568419300431 DMVR628 DI DMVR628 DMVR628 DN Vindesine DMVR628 MI DTUGYRD DMVR628 MN P-glycoprotein 1 (ABCB1) DMVR628 MT DTP DMVR628 MA Substrate DMVR628 RN Human intestinal transporter database: QSAR modeling and virtual profiling of drug uptake, efflux and interactions. Pharm Res. 2013 Apr;30(4):996-1007. DMVR628 RU https://doi.org/10.1007/s11095-012-0935-x DMVR628 DI DMVR628 DMVR628 DN Vindesine DMVR628 MI TTYFKSZ DMVR628 MN Tubulin beta (TUBB) DMVR628 MT DTT DMVR628 MA Binder DMVR628 RN Antiproliferating activity of the mitotic inhibitor pironetin against vindesine- and paclitaxel-resistant human small cell lung cancer H69 cells. Anticancer Res. 2007 Mar-Apr;27(2):729-36. DMVR628 RU https://pubmed.ncbi.nlm.nih.gov/17465195 DMVXFYE DI DMVXFYE DMVXFYE DN Vinorelbine DMVXFYE MI DECB0K3 DMVXFYE MN Cytochrome P450 2D6 (CYP2D6) DMVXFYE MT DME DMVXFYE MA Metabolism DMVXFYE RN Inhibitory effects of anticancer drugs on dextromethorphan-O-demethylase activity in human liver microsomes. Cancer Chemother Pharmacol. 1993;32(6):491-5. DMVXFYE RU https://www.ncbi.nlm.nih.gov/pubmed/?term=8258200 DMVXFYE DI DMVXFYE DMVXFYE DN Vinorelbine DMVXFYE MI DE4LYSA DMVXFYE MN Cytochrome P450 3A4 (CYP3A4) DMVXFYE MT DME DMVXFYE MA Metabolism DMVXFYE RN Characterization of human cytochrome P450 isoenzymes involved in the metabolism of vinorelbine. Fundam Clin Pharmacol. 2005 Oct;19(5):545-53. DMVXFYE RU https://www.ncbi.nlm.nih.gov/pubmed/?term=16176333 DMVXFYE DI DMVXFYE DMVXFYE DN Vinorelbine DMVXFYE MI DTUGYRD DMVXFYE MN P-glycoprotein 1 (ABCB1) DMVXFYE MT DTP DMVXFYE MA Substrate DMVXFYE RN Rational use of in vitro P-glycoprotein assays in drug discovery. J Pharmacol Exp Ther. 2001 Nov;299(2):620-8. DMVXFYE RU http://www.ncbi.nlm.nih.gov/pubmed/11602674 DMVXFYE DI DMVXFYE DMVXFYE DN Vinorelbine DMVXFYE MI TTML2WA DMVXFYE MN Tubulin (TUB) DMVXFYE MT DTT DMVXFYE MA Inhibitor DMVXFYE RN Vinca alkaloid and MDR1. Gan To Kagaku Ryoho. 2008 Jul;35(7):1086-9. DMVXFYE RU https://pubmed.ncbi.nlm.nih.gov/18633246 DMVN2E6 DI DMVN2E6 DMVN2E6 DN Vinpocetine DMVN2E6 MI DE4LYSA DMVN2E6 MN Cytochrome P450 3A4 (CYP3A4) DMVN2E6 MT DME DMVN2E6 MA Metabolism DMVN2E6 RN Integrated analysis on the physicochemical properties of dihydropyridine calcium channel blockers in grapefruit juice interactions. Curr Pharm Biotechnol. 2012 Jul;13(9):1705-17. DMVN2E6 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=22039822 DMVN2E6 DI DMVN2E6 DMVN2E6 DN Vinpocetine DMVN2E6 MI TTHQENC DMVN2E6 MN Phosphodiesterase 1 (PDE1) DMVN2E6 MT DTT DMVN2E6 MA Inhibitor DMVN2E6 RN Effects of phosphodiesterase inhibitors on contraction induced by endothelin-1 of isolated human prostatic tissue. Urology. 2009 Jun;73(6):1397-401. DMVN2E6 RU https://pubmed.ncbi.nlm.nih.gov/19285714 DMZYLFC DI DMZYLFC DMZYLFC DN Viomycin sulfate DMZYLFC MI TTIA0J5 DMZYLFC MN Bacterial 70S ribosomal RNA (Bact 70S rRNA) DMZYLFC MT DTT DMZYLFC MA Modulator DMZYLFC RN The antibiotic viomycin traps the ribosome in an intermediate state of translocation.Nat Struct Mol Biol.2007 Jun;14(6):493-7. DMZYLFC RU https://www.ncbi.nlm.nih.gov/pubmed/17515906 DM0REZS DI DM0REZS DM0REZS DN Virulizin DM0REZS MI TTD2MLN DM0REZS MN Natural killer cell activation (NKA) DM0REZS MT DTT DM0REZS MA Modulator DM0REZS RN Virulizin, a novel immunotherapy agent, activates NK cells through induction of IL-12 expression in macrophages. Cancer Immunol Immunother. 2005 Nov;54(11):1115-26. DM0REZS RU https://pubmed.ncbi.nlm.nih.gov/15891881 DM5IXKQ DI DM5IXKQ DM5IXKQ DN Vismodegib DM5IXKQ MI DE5IED8 DM5IXKQ MN Cytochrome P450 2C9 (CYP2C9) DM5IXKQ MT DME DM5IXKQ MA Metabolism DM5IXKQ RN The dawn of hedgehog inhibitors: Vismodegib. J Pharmacol Pharmacother. 2013 Jan;4(1):4-7. DM5IXKQ RU https://www.ncbi.nlm.nih.gov/pubmed/?term=23662017 DM5IXKQ DI DM5IXKQ DM5IXKQ DN Vismodegib DM5IXKQ MI DE4LYSA DM5IXKQ MN Cytochrome P450 3A4 (CYP3A4) DM5IXKQ MT DME DM5IXKQ MA Metabolism DM5IXKQ RN The dawn of hedgehog inhibitors: Vismodegib. J Pharmacol Pharmacother. 2013 Jan;4(1):4-7. DM5IXKQ RU https://www.ncbi.nlm.nih.gov/pubmed/?term=23662017 DM5IXKQ DI DM5IXKQ DM5IXKQ DN Vismodegib DM5IXKQ MI TT8J1S3 DM5IXKQ MN Smoothened homolog (SMO) DM5IXKQ MT DTT DM5IXKQ MA Modulator DM5IXKQ RN Nat Rev Drug Discov. 2013 Feb;12(2):87-90. DM5IXKQ RU https://pubmed.ncbi.nlm.nih.gov/23370234 DMJ2AH4 DI DMJ2AH4 DMJ2AH4 DN Vitamin A DMJ2AH4 MI DEJGDUW DMJ2AH4 MN Cytochrome P450 1A2 (CYP1A2) DMJ2AH4 MT DME DMJ2AH4 MA Metabolism DMJ2AH4 RN Carotenoids as regulators for inter-species difference in cytochrome P450 1A expression and activity in ungulates and rats. Food Chem Toxicol. 2010 Nov;48(11):3201-8. DMJ2AH4 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=20797421 DMJ2AH4 DI DMJ2AH4 DMJ2AH4 DN Vitamin A DMJ2AH4 MI DE9QHP6 DMJ2AH4 MN Cytochrome P450 1B1 (CYP1B1) DMJ2AH4 MT DME DMJ2AH4 MA Metabolism DMJ2AH4 RN Metabolism of retinoids and arachidonic acid by human and mouse cytochrome P450 1b1. Drug Metab Dispos. 2004 Aug;32(8):840-7. DMJ2AH4 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=15258110 DMJ2AH4 DI DMJ2AH4 DMJ2AH4 DN Vitamin A DMJ2AH4 MI DES5XRU DMJ2AH4 MN Cytochrome P450 2C8 (CYP2C8) DMJ2AH4 MT DME DMJ2AH4 MA Metabolism DMJ2AH4 RN Effects of arachidonic acid, prostaglandins, retinol, retinoic acid and cholecalciferol on xenobiotic oxidations catalysed by human cytochrome P450 enzymes. Xenobiotica. 1999 Mar;29(3):231-41. DMJ2AH4 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=10219964 DMJ2AH4 DI DMJ2AH4 DMJ2AH4 DN Vitamin A DMJ2AH4 MI DEVDYN7 DMJ2AH4 MN Cytochrome P450 2E1 (CYP2E1) DMJ2AH4 MT DME DMJ2AH4 MA Metabolism DMJ2AH4 RN The role of inflammatory cells and cytochrome P450 in the potentiation of CCl4-induced liver injury by a single dose of retinol. Toxicol Appl Pharmacol. 1996 Dec;141(2):507-19. DMJ2AH4 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=8975775 DMJ2AH4 DI DMJ2AH4 DMJ2AH4 DN Vitamin A DMJ2AH4 MI DE6NMGO DMJ2AH4 MN Cytochrome P450 2S1 (CYP2S1) DMJ2AH4 MT DME DMJ2AH4 MA Metabolism DMJ2AH4 RN The involvement of cytochrome p450 (CYP) 26 in the retinoic acid metabolism of human epidermal keratinocytes. Biochim Biophys Acta. 2009 Mar;1791(3):220-8. DMJ2AH4 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=19171200 DMJ2AH4 DI DMJ2AH4 DMJ2AH4 DN Vitamin A DMJ2AH4 MI DE4LYSA DMJ2AH4 MN Cytochrome P450 3A4 (CYP3A4) DMJ2AH4 MT DME DMJ2AH4 MA Metabolism DMJ2AH4 RN Biosynthesis of all-trans-retinoic acid from all-trans-retinol: catalysis of all-trans-retinol oxidation by human P-450 cytochromes. Drug Metab Dispos. 2000 Mar;28(3):315-22. DMJ2AH4 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=10681376 DMJ2AH4 DI DMJ2AH4 DMJ2AH4 DN Vitamin A DMJ2AH4 MI DEKN1H4 DMJ2AH4 MN Retinal dehydrogenase 2 (ALDH1A2) DMJ2AH4 MT DME DMJ2AH4 MA Metabolism DMJ2AH4 RN Vitamin A metabolism by dendritic cells triggers an antimicrobial response against Mycobacterium tuberculosis. mSphere. 2019 Jun 5;4(3). pii: e00327-19. DMJ2AH4 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=31167948 DMJ2AH4 DI DMJ2AH4 DMJ2AH4 DN Vitamin A DMJ2AH4 MI DEOVJF2 DMJ2AH4 MN Retinoic acid 4-hydroxylase 26A1 (CYP26A1) DMJ2AH4 MT DME DMJ2AH4 MA Metabolism DMJ2AH4 RN Induction of CYP26A1 by metabolites of retinoic acid: evidence that CYP26A1 is an important enzyme in the elimination of active retinoids. Mol Pharmacol. 2015;87(3):430-41. DMJ2AH4 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=25492813 DMJ2AH4 DI DMJ2AH4 DMJ2AH4 DN Vitamin A DMJ2AH4 MI TTOD7B3 DMJ2AH4 MN Retinoic acid receptor (RAR) DMJ2AH4 MT DTT DMJ2AH4 MA Binder DMJ2AH4 RN Vitamins and cofactors: highlights of ESBOC 2009. Nat Chem Biol. 2009 Aug;5(8):530-3. DMJ2AH4 RU https://pubmed.ncbi.nlm.nih.gov/19620989 DMJ2AH4 DI DMJ2AH4 DMJ2AH4 DN Vitamin A DMJ2AH4 MI TTH029C DMJ2AH4 MN Retinoic acid receptor RXR-gamma (RXRG) DMJ2AH4 MT DTT DMJ2AH4 MA Binder DMJ2AH4 RN Vitamins and cofactors: highlights of ESBOC 2009. Nat Chem Biol. 2009 Aug;5(8):530-3. DMJ2AH4 RU https://pubmed.ncbi.nlm.nih.gov/19620989 DMJ2AH4 DI DMJ2AH4 DMJ2AH4 DN Vitamin A DMJ2AH4 MI DESI4OK DMJ2AH4 MN Retinol dehydrogenase 5 (RDH5) DMJ2AH4 MT DME DMJ2AH4 MA Metabolism DMJ2AH4 RN Generation of retinaldehyde for retinoic acid biosynthesis. Biomolecules. 2019 Dec 18;10(1). pii: E5. DMJ2AH4 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=31861321 DMJ2AH4 DI DMJ2AH4 DMJ2AH4 DN Vitamin A DMJ2AH4 MI DEGTU5I DMJ2AH4 MN Short-chain dehydrogenase/reductase retSDR8 (DHRS9) DMJ2AH4 MT DME DMJ2AH4 MA Metabolism DMJ2AH4 RN Vitamin A metabolism by dendritic cells triggers an antimicrobial response against Mycobacterium tuberculosis. mSphere. 2019 Jun 5;4(3). pii: e00327-19. DMJ2AH4 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=31167948 DMJ2AH4 DI DMJ2AH4 DMJ2AH4 DN Vitamin A DMJ2AH4 MI TTRTKPV DMJ2AH4 MN Trypanosoma Trypanothione reductase (Trypano TPR) DMJ2AH4 MT DTT DMJ2AH4 MA Binder DMJ2AH4 RN Opportunities and challenges in antiparasitic drug discovery. Nat Rev Drug Discov. 2005 Sep;4(9):727-40. DMJ2AH4 RU https://pubmed.ncbi.nlm.nih.gov/16138106 DMZ1WXJ DI DMZ1WXJ DMZ1WXJ DN Vitamin B1 DMZ1WXJ MI TT8RHGB DMZ1WXJ MN Bacterial Pyruvate decarboxylase (Bact aceE) DMZ1WXJ MT DTT DMZ1WXJ MA Cofactor DMZ1WXJ RN Vitamins and cofactors: highlights of ESBOC 2009. Nat Chem Biol. 2009 Aug;5(8):530-3. DMZ1WXJ RU https://pubmed.ncbi.nlm.nih.gov/19620989 DMZ1WXJ DI DMZ1WXJ DMZ1WXJ DN Vitamin B1 DMZ1WXJ MI DT8KXR9 DMZ1WXJ MN Choline transporter-like protein 4 (SLC44A4) DMZ1WXJ MT DTP DMZ1WXJ MA Substrate DMZ1WXJ RN Molecular identification and functional characterization of the human colonic thiamine pyrophosphate transporter. J Biol Chem. 2017 Oct 6;292(40):16526. DMZ1WXJ RU http://www.ncbi.nlm.nih.gov/pubmed/28986434 DMZ1WXJ DI DMZ1WXJ DMZ1WXJ DN Vitamin B1 DMZ1WXJ MI DTEHSG0 DMZ1WXJ MN Putative thiamine transporter SLC35F3 (SLC35F3) DMZ1WXJ MT DTP DMZ1WXJ MA Substrate DMZ1WXJ RN Genetic implication of a novel thiamine transporter in human hypertension. J Am Coll Cardiol. 2014 Apr 22;63(15):1542-55. DMZ1WXJ RU http://www.ncbi.nlm.nih.gov/pubmed/24509276 DMZ1WXJ DI DMZ1WXJ DMZ1WXJ DN Vitamin B1 DMZ1WXJ MI DT39CEA DMZ1WXJ MN Thiamine transporter 2 (SLC19A3) DMZ1WXJ MT DTP DMZ1WXJ MA Substrate DMZ1WXJ RN Folate and thiamine transporters mediated by facilitative carriers (SLC19A1-3 and SLC46A1) and folate receptors. Mol Aspects Med. 2013 Apr-Jun;34(2-3):373-85. DMZ1WXJ RU http://www.ncbi.nlm.nih.gov/pubmed/23506878 DMQVRZH DI DMQVRZH DMQVRZH DN Vitamin B3 DMQVRZH MI DEGF70S DMQVRZH MN Cyclic ADP-ribose hydrolase 1 (CD38) DMQVRZH MT DME DMQVRZH MA Metabolism DMQVRZH RN ADP-ribosyl cyclase and CD38 catalyze the synthesis of a calcium-mobilizing metabolite from NADP. J Biol Chem. 1995 Dec 22;270(51):30327-33. DMQVRZH RU https://www.ncbi.nlm.nih.gov/pubmed/?term=8530456 DMQVRZH DI DMQVRZH DMQVRZH DN Vitamin B3 DMQVRZH MI TTRHEQ4 DMQVRZH MN Diacylglycerol O-acyltransferase 2 (DGAT2) DMQVRZH MT DTT DMQVRZH MA Inhibitor DMQVRZH RN Hakozaki T, Minwalla L, Zhuang J, Chhoa M, Matsubara A, Miyamoto K, Greatens A, Hillebrand GG, Bissett DL, Boissy RE: The effect of niacinamide on reducing cutaneous pigmentation and suppression of melanosome transfer. Br J Dermatol. 2002 Jul;147(1):20-31. DMQVRZH RU https://pubmed.ncbi.nlm.nih.gov/12100180 DMQVRZH DI DMQVRZH DMQVRZH DN Vitamin B3 DMQVRZH MI TTWNV8U DMQVRZH MN Nicotinic acid receptor (HCAR2) DMQVRZH MT DTT DMQVRZH MA Agonist DMQVRZH RN Hakozaki T, Minwalla L, Zhuang J, Chhoa M, Matsubara A, Miyamoto K, Greatens A, Hillebrand GG, Bissett DL, Boissy RE: The effect of niacinamide on reducing cutaneous pigmentation and suppression of melanosome transfer. Br J Dermatol. 2002 Jul;147(1):20-31. DMQVRZH RU https://pubmed.ncbi.nlm.nih.gov/12100180 DMDBZMV DI DMDBZMV DMDBZMV DN Vitamin B6 DMDBZMV MI TTN451K DMDBZMV MN Aromatic-L-amino-acid decarboxylase (DDC) DMDBZMV MT DTT DMDBZMV MA Cofactor DMDBZMV RN Functional COMT variant predicts response to high dose pyridoxine in Parkinson's disease. Am J Med Genet B Neuropsychiatr Genet. 2005 Aug 5;137B(1):1-4. DMDBZMV RU https://pubmed.ncbi.nlm.nih.gov/15965967 DMDBZMV DI DMDBZMV DMDBZMV DN Vitamin B6 DMDBZMV MI DE2UNSW DMDBZMV MN Pyridoxal phosphate phosphatase (PDXP) DMDBZMV MT DME DMDBZMV MA Metabolism DMDBZMV RN Purification and characterization of vitamin B6-phosphate phosphatase from human erythrocytes. J Biol Chem. 1992 Aug 5;267(22):15978-83. DMDBZMV RU https://www.ncbi.nlm.nih.gov/pubmed/?term=1322411 DMXJ7O8 DI DMXJ7O8 DMXJ7O8 DN Vitamin C DMXJ7O8 MI TTK982E DMXJ7O8 MN Collagen (CO) DMXJ7O8 MT DTT DMXJ7O8 MA Activator DMXJ7O8 RN Effects of vitamin C on dark circles of the lower eyelids: quantitative evaluation using image analysis and echogram. Skin Res Technol. 2009 May;15(2):214-7. DMXJ7O8 RU https://pubmed.ncbi.nlm.nih.gov/19626722 DMXJ7O8 DI DMXJ7O8 DMXJ7O8 DN Vitamin C DMXJ7O8 MI DEWO724 DMXJ7O8 MN HIF-prolyl hydroxylase 2 (EGLN1) DMXJ7O8 MT DME DMXJ7O8 MA Metabolism DMXJ7O8 RN Characterization of the human prolyl 4-hydroxylases that modify the hypoxia-inducible factor. J Biol Chem. 2003 Aug 15;278(33):30772-80. DMXJ7O8 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=12788921 DMXJ7O8 DI DMXJ7O8 DMXJ7O8 DN Vitamin C DMXJ7O8 MI DESO5ZY DMXJ7O8 MN Prolyl 4-hydroxylase alpha-1 (P4HA1) DMXJ7O8 MT DME DMXJ7O8 MA Metabolism DMXJ7O8 RN Prolyl 4-hydroxylases, the key enzymes of collagen biosynthesis. Matrix Biol. 2003 Mar;22(1):15-24. DMXJ7O8 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=12714038 DMXJ7O8 DI DMXJ7O8 DMXJ7O8 DN Vitamin C DMXJ7O8 MI DE5EGK0 DMXJ7O8 MN Prolyl 4-hydroxylase alpha-2 (P4HA2) DMXJ7O8 MT DME DMXJ7O8 MA Metabolism DMXJ7O8 RN Prolyl 4-hydroxylases, the key enzymes of collagen biosynthesis. Matrix Biol. 2003 Mar;22(1):15-24. DMXJ7O8 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=12714038 DMXJ7O8 DI DMXJ7O8 DMXJ7O8 DN Vitamin C DMXJ7O8 MI DE2L4RX DMXJ7O8 MN Prolyl 4-hydroxylase alpha-3 (P4HA3) DMXJ7O8 MT DME DMXJ7O8 MA Metabolism DMXJ7O8 RN Identification and characterization of a third human, rat, and mouse collagen prolyl 4-hydroxylase isoenzyme. J Biol Chem. 2003 Nov 28;278(48):47685-93. DMXJ7O8 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=14500733 DMXJ7O8 DI DMXJ7O8 DMXJ7O8 DN Vitamin C DMXJ7O8 MI DT3KH2X DMXJ7O8 MN Sodium-dependent vitamin C transporter 1 (SLC23A1) DMXJ7O8 MT DTP DMXJ7O8 MA Substrate DMXJ7O8 RN A family of mammalian Na+-dependent L-ascorbic acid transporters. Nature. 1999 May 6;399(6731):70-5. DMXJ7O8 RU http://www.ncbi.nlm.nih.gov/pubmed/10331392 DMXJ7O8 DI DMXJ7O8 DMXJ7O8 DN Vitamin C DMXJ7O8 MI DTVY9PJ DMXJ7O8 MN Sodium-dependent vitamin C transporter 2 (SLC23A2) DMXJ7O8 MT DTP DMXJ7O8 MA Substrate DMXJ7O8 RN Molecular characterization and transcriptional regulation of the sodium-dependent vitamin C transporter genes (slc23a1 and slc23a2) in a teleost fish, the Senegalese sole (Solea senegalensis). Comp Biochem Physiol B Biochem Mol Biol. 2012 Mar;161(3):208-18. DMXJ7O8 RU http://www.ncbi.nlm.nih.gov/pubmed/22142801 DMXJ7O8 DI DMXJ7O8 DMXJ7O8 DN Vitamin C DMXJ7O8 MI TT6XAGK DMXJ7O8 MN Solute carrier family 23 member 1 (SLC23A1) DMXJ7O8 MT DTT DMXJ7O8 MA Modulator DMXJ7O8 RN Decreased expression of the vitamin C transporter SVCT1 by ascorbic acid in a human intestinal epithelial cell line. Br J Nutr. 2002 Feb;87(2):97-100. DMXJ7O8 RU https://pubmed.ncbi.nlm.nih.gov/11895172 DMXJ7O8 DI DMXJ7O8 DMXJ7O8 DN Vitamin C DMXJ7O8 MI TTOP832 DMXJ7O8 MN Solute carrier family 23 member 2 (SLC23A2) DMXJ7O8 MT DTT DMXJ7O8 MA Modulator DMXJ7O8 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1042). DMXJ7O8 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1042 DMXJ7O8 DI DMXJ7O8 DMXJ7O8 DN Vitamin C DMXJ7O8 MI DEFQ8VO DMXJ7O8 MN Thiopurine methyltransferase (TPMT) DMXJ7O8 MT DME DMXJ7O8 MA Metabolism DMXJ7O8 RN Ascorbic acid inhibits spinal meningeal catechol-o-methyl transferase in vitro, markedly increasing epinephrine bioavailability. Anesthesiology. 1997 Feb;86(2):405-9. DMXJ7O8 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=9054258 DMWQUC9 DI DMWQUC9 DMWQUC9 DN Vitamin D DMWQUC9 MI DE98XPV DMWQUC9 MN Cholesterol desmolase (CYP11A1) DMWQUC9 MT DME DMWQUC9 MA Metabolism DMWQUC9 RN Metabolism of 1alpha-hydroxyvitamin D3 by cytochrome P450scc to biologically active 1alpha,20-dihydroxyvitamin D3. J Steroid Biochem Mol Biol. 2008 Dec;112(4-5):213-9. DMWQUC9 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=19000766 DMWQUC9 DI DMWQUC9 DMWQUC9 DN Vitamin D DMWQUC9 MI DE28NZ9 DMWQUC9 MN Cytochrome P450 124 (cyp124) DMWQUC9 MT DME DMWQUC9 MA Metabolism DMWQUC9 RN Identification of Mycobacterium tuberculosis enzyme involved in vitamin D and 7-dehydrocholesterol metabolism. J Steroid Biochem Mol Biol. 2017 May;169:202-209. DMWQUC9 RU https://pubmed.ncbi.nlm.nih.gov/27289046 DMWQUC9 DI DMWQUC9 DMWQUC9 DN Vitamin D DMWQUC9 MI DERSX5P DMWQUC9 MN Cytochrome P450 2J2 (CYP2J2) DMWQUC9 MT DME DMWQUC9 MA Metabolism DMWQUC9 RN Characterization of rat and human CYP2J enzymes as Vitamin D 25-hydroxylases. Steroids. 2006 Oct;71(10):849-56. DMWQUC9 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=16842832 DMWQUC9 DI DMWQUC9 DMWQUC9 DN Vitamin D DMWQUC9 MI DE4LYSA DMWQUC9 MN Cytochrome P450 3A4 (CYP3A4) DMWQUC9 MT DME DMWQUC9 MA Metabolism DMWQUC9 RN Interplay between vitamin D and the drug metabolizing enzyme CYP3A4. J Steroid Biochem Mol Biol. 2013 Jul;136:54-8. DMWQUC9 RU https://www.ncbi.nlm.nih.gov/pubmed/22985909 DMWQUC9 DI DMWQUC9 DMWQUC9 DN Vitamin D DMWQUC9 MI DEBIHM3 DMWQUC9 MN Vitamin D 25-hydroxylase (CYP2R1) DMWQUC9 MT DME DMWQUC9 MA Metabolism DMWQUC9 RN Placental vitamin D metabolism and its associations with circulating vitamin D metabolites in pregnant women. Am J Clin Nutr. 2017 Dec;106(6):1439-1448. DMWQUC9 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=29021285 DMWQUC9 DI DMWQUC9 DMWQUC9 DN Vitamin D DMWQUC9 MI DEBS639 DMWQUC9 MN Vitamin D(3) 25-hydroxylase (CYP27A1) DMWQUC9 MT DME DMWQUC9 MA Metabolism DMWQUC9 RN Chemoprevention of prostate cancer by cholecalciferol (vitamin D3): 25-hydroxylase (CYP27A1) in human prostate epithelial cells. Clin Exp Metastasis. 2005;22(3):265-73. DMWQUC9 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=16158254 DMZC90K DI DMZC90K DMZC90K DN Vitamin E DMZC90K MI DE4LYSA DMZC90K MN Cytochrome P450 3A4 (CYP3A4) DMZC90K MT DME DMZC90K MA Metabolism DMZC90K RN Adverse effects of vitamin E by induction of drug metabolism. Genes Nutr. 2007 Dec;2(3):249-56. DMZC90K RU https://www.ncbi.nlm.nih.gov/pubmed/?term=18850180 DMWIJTN DI DMWIJTN DMWIJTN DN Voclosporin DMWIJTN MI TTA4LDE DMWIJTN MN Calcineurin (PPP3CA) DMWIJTN MT DTT DMWIJTN MA Inhibitor DMWIJTN RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health Human Services. 2021 DMWIJTN RU https://www.accessdata.fda.gov/drugsatfda_docs/label/2021/213716s000lbl.pdf DMUBP9O DI DMUBP9O DMUBP9O DN Voglibose DMUBP9O MI TTXWASR DMUBP9O MN Intestinal maltase-glucoamylase (MGAM) DMUBP9O MT DTT DMUBP9O MA Inhibitor DMUBP9O RN Effects of changeover from voglibose to acarbose on postprandial triglycerides in type 2 diabetes mellitus patients. Adv Ther. 2009 Jun;26(6):660-6. DMUBP9O RU https://pubmed.ncbi.nlm.nih.gov/19568704 DM1YEPS DI DM1YEPS DM1YEPS DN Volanesorsen DM1YEPS MI TTXOZQ1 DM1YEPS MN ApoC-III messenger RNA (APOC3 mRNA) DM1YEPS MT DTT DM1YEPS MA Inhibitor DM1YEPS RN Metabolism and Disposition of Volanesorsen, a 2'- O-(2 methoxyethyl) Antisense Oligonucleotide, Across Species. Drug Metab Dispos. 2019 Oct;47(10):1164-1173. DM1YEPS RU https://pubmed.ncbi.nlm.nih.gov/31350288 DMO6315 DI DMO6315 DMO6315 DN Vonoprazan DMO6315 MI TTLOKXP DMO6315 MN Gastric H(+)/K(+) ATPase (Proton pump) DMO6315 MT DTT DMO6315 MA Modulator DMO6315 RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health Human Services. 2008 DMO6315 RU https://www.accessdata.fda.gov/drugsatfda_docs/label/2008/020973s022lbl.pdf DMI783H DI DMI783H DMI783H DN Vonvendi DMI783H MI TT3SZBT DMI783H MN von Willebrand factor (VWF) DMI783H MT DTT DMI783H MA Replacement DMI783H RN Clinical pipeline report, company report or official report of Vonvendi. DMI783H RU https://www.vonvendi.com/ DMA16BR DI DMA16BR DMA16BR DN Vorapaxar DMA16BR MI DERSX5P DMA16BR MN Cytochrome P450 2J2 (CYP2J2) DMA16BR MT DME DMA16BR MA Metabolism DMA16BR RN Vorapaxar: the missing link in antiplatelet therapy! J Anaesthesiol Clin Pharmacol. 2017 Apr-Jun;33(2):269-270. DMA16BR RU https://www.ncbi.nlm.nih.gov/pubmed/?term=28781465 DMA16BR DI DMA16BR DMA16BR DN Vorapaxar DMA16BR MI DE4LYSA DMA16BR MN Cytochrome P450 3A4 (CYP3A4) DMA16BR MT DME DMA16BR MA Metabolism DMA16BR RN Vorapaxar: the missing link in antiplatelet therapy! J Anaesthesiol Clin Pharmacol. 2017 Apr-Jun;33(2):269-270. DMA16BR RU https://www.ncbi.nlm.nih.gov/pubmed/?term=28781465 DMA16BR DI DMA16BR DMA16BR DN Vorapaxar DMA16BR MI TTL935N DMA16BR MN Proteinase activated receptor 1 (F2R) DMA16BR MT DTT DMA16BR MA Antagonist DMA16BR RN In Process Citation. Pharm Unserer Zeit. 2009;38(4):320-8. DMA16BR RU https://pubmed.ncbi.nlm.nih.gov/19572350 DMAOL2S DI DMAOL2S DMAOL2S DN Voriconazole DMAOL2S MI TTTSOUD DMAOL2S MN Candida Cytochrome P450 51 (Candi ERG11) DMAOL2S MT DTT DMAOL2S MA Modulator DMAOL2S RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. DMAOL2S RU https://www.fda.gov/ DMAOL2S DI DMAOL2S DMAOL2S DN Voriconazole DMAOL2S MI DE5IED8 DMAOL2S MN Cytochrome P450 2C9 (CYP2C9) DMAOL2S MT DME DMAOL2S MA Metabolism DMAOL2S RN Effect of voriconazole on the pharmacokinetics of diclofenac. Fundam Clin Pharmacol. 2007 Dec;21(6):651-6. DMAOL2S RU https://www.ncbi.nlm.nih.gov/pubmed/?term=18034666 DMAOL2S DI DMAOL2S DMAOL2S DN Voriconazole DMAOL2S MI DE4LYSA DMAOL2S MN Cytochrome P450 3A4 (CYP3A4) DMAOL2S MT DME DMAOL2S MA Metabolism DMAOL2S RN Roles of CYP3A4 and CYP2C19 in methyl hydroxylated and N-oxidized metabolite formation from voriconazole, a new anti-fungal agent, in human liver microsomes. Biochem Pharmacol. 2007 Jun 15;73(12):2020-6. DMAOL2S RU https://www.ncbi.nlm.nih.gov/pubmed/?term=17433262 DMAOL2S DI DMAOL2S DMAOL2S DN Voriconazole DMAOL2S MI DEGTFWK DMAOL2S MN Mephenytoin 4-hydroxylase (CYP2C19) DMAOL2S MT DME DMAOL2S MA Metabolism DMAOL2S RN Effect of voriconazole on the pharmacokinetics of diclofenac. Fundam Clin Pharmacol. 2007 Dec;21(6):651-6. DMAOL2S RU https://www.ncbi.nlm.nih.gov/pubmed/?term=18034666 DMAOL2S DI DMAOL2S DMAOL2S DN Voriconazole DMAOL2S MI DE073H6 DMAOL2S MN Prostaglandin G/H synthase 1 (COX-1) DMAOL2S MT DME DMAOL2S MA Metabolism DMAOL2S RN Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. DMAOL2S RU https://www.ncbi.nlm.nih.gov/pubmed/?term=19515014 DMWMPD4 DI DMWMPD4 DMWMPD4 DN Vorinostat DMWMPD4 MI TT6R7JZ DMWMPD4 MN Histone deacetylase 1 (HDAC1) DMWMPD4 MT DTT DMWMPD4 MA Inhibitor DMWMPD4 RN Protein methyltransferases as a target class for drug discovery. Nat Rev Drug Discov. 2009 Sep;8(9):724-32. DMWMPD4 RU https://pubmed.ncbi.nlm.nih.gov/19721445 DMWMPD4 DI DMWMPD4 DMWMPD4 DN Vorinostat DMWMPD4 MI DEYGVN4 DMWMPD4 MN UDP-glucuronosyltransferase 1A1 (UGT1A1) DMWMPD4 MT DME DMWMPD4 MA Metabolism DMWMPD4 RN A pharmacogenetic study of vorinostat glucuronidation. Pharmacogenet Genomics. 2010 Oct;20(10):638-41. DMWMPD4 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=20729791 DMWMPD4 DI DMWMPD4 DMWMPD4 DN Vorinostat DMWMPD4 MI DEF2WXN DMWMPD4 MN UDP-glucuronosyltransferase 1A3 (UGT1A3) DMWMPD4 MT DME DMWMPD4 MA Metabolism DMWMPD4 RN Uridine 5'-diphospho-glucuronosyltransferase genetic polymorphisms and response to cancer chemotherapy. Future Oncol. 2010 Apr;6(4):563-85. DMWMPD4 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=20373870 DMWMPD4 DI DMWMPD4 DMWMPD4 DN Vorinostat DMWMPD4 MI DEZO4N3 DMWMPD4 MN UDP-glucuronosyltransferase 1A7 (UGT1A7) DMWMPD4 MT DME DMWMPD4 MA Metabolism DMWMPD4 RN Uridine 5'-diphospho-glucuronosyltransferase genetic polymorphisms and response to cancer chemotherapy. Future Oncol. 2010 Apr;6(4):563-85. DMWMPD4 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=20373870 DMWMPD4 DI DMWMPD4 DMWMPD4 DN Vorinostat DMWMPD4 MI DE2GB8N DMWMPD4 MN UDP-glucuronosyltransferase 1A8 (UGT1A8) DMWMPD4 MT DME DMWMPD4 MA Metabolism DMWMPD4 RN Uridine 5'-diphospho-glucuronosyltransferase genetic polymorphisms and response to cancer chemotherapy. Future Oncol. 2010 Apr;6(4):563-85. DMWMPD4 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=20373870 DMWMPD4 DI DMWMPD4 DMWMPD4 DN Vorinostat DMWMPD4 MI DE85D2P DMWMPD4 MN UDP-glucuronosyltransferase 1A9 (UGT1A9) DMWMPD4 MT DME DMWMPD4 MA Metabolism DMWMPD4 RN Age-dependent hepatic UDP-glucuronosyltransferase gene expression and activity in children. Front Pharmacol. 2016 Nov 16;7:437. DMWMPD4 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=27899892 DMWMPD4 DI DMWMPD4 DMWMPD4 DN Vorinostat DMWMPD4 MI DEAZDL8 DMWMPD4 MN UDP-glucuronosyltransferase 2B17 (UGT2B17) DMWMPD4 MT DME DMWMPD4 MA Metabolism DMWMPD4 RN Age-dependent hepatic UDP-glucuronosyltransferase gene expression and activity in children. Front Pharmacol. 2016 Nov 16;7:437. DMWMPD4 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=27899892 DMWMPD4 DI DMWMPD4 DMWMPD4 DN Vorinostat DMWMPD4 MI DEB3CV1 DMWMPD4 MN UDP-glucuronosyltransferase 2B7 (UGT2B7) DMWMPD4 MT DME DMWMPD4 MA Metabolism DMWMPD4 RN Age-dependent hepatic UDP-glucuronosyltransferase gene expression and activity in children. Front Pharmacol. 2016 Nov 16;7:437. DMWMPD4 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=27899892 DM6F1PU DI DM6F1PU DM6F1PU DN Vortioxetine DM6F1PU MI DEJVYAZ DM6F1PU MN Cytochrome P450 2A6 (CYP2A6) DM6F1PU MT DME DM6F1PU MA Metabolism DM6F1PU RN Identification of the cytochrome P450 and other enzymes involved in the in vitro oxidative metabolism of a novel antidepressant, Lu AA21004. Drug Metab Dispos. 2012 Jul;40(7):1357-65. DM6F1PU RU https://www.ncbi.nlm.nih.gov/pubmed/?term=22496396 DM6F1PU DI DM6F1PU DM6F1PU DN Vortioxetine DM6F1PU MI DEPKLMQ DM6F1PU MN Cytochrome P450 2B6 (CYP2B6) DM6F1PU MT DME DM6F1PU MA Metabolism DM6F1PU RN Identification of the cytochrome P450 and other enzymes involved in the in vitro oxidative metabolism of a novel antidepressant, Lu AA21004. Drug Metab Dispos. 2012 Jul;40(7):1357-65. DM6F1PU RU https://www.ncbi.nlm.nih.gov/pubmed/?term=22496396 DM6F1PU DI DM6F1PU DM6F1PU DN Vortioxetine DM6F1PU MI DES5XRU DM6F1PU MN Cytochrome P450 2C8 (CYP2C8) DM6F1PU MT DME DM6F1PU MA Metabolism DM6F1PU RN Identification of the cytochrome P450 and other enzymes involved in the in vitro oxidative metabolism of a novel antidepressant, Lu AA21004. Drug Metab Dispos. 2012 Jul;40(7):1357-65. DM6F1PU RU https://www.ncbi.nlm.nih.gov/pubmed/?term=22496396 DM6F1PU DI DM6F1PU DM6F1PU DN Vortioxetine DM6F1PU MI DE5IED8 DM6F1PU MN Cytochrome P450 2C9 (CYP2C9) DM6F1PU MT DME DM6F1PU MA Metabolism DM6F1PU RN Identification of the cytochrome P450 and other enzymes involved in the in vitro oxidative metabolism of a novel antidepressant, Lu AA21004. Drug Metab Dispos. 2012 Jul;40(7):1357-65. DM6F1PU RU https://www.ncbi.nlm.nih.gov/pubmed/?term=22496396 DM6F1PU DI DM6F1PU DM6F1PU DN Vortioxetine DM6F1PU MI DECB0K3 DM6F1PU MN Cytochrome P450 2D6 (CYP2D6) DM6F1PU MT DME DM6F1PU MA Metabolism DM6F1PU RN Identification of the cytochrome P450 and other enzymes involved in the in vitro oxidative metabolism of a novel antidepressant, Lu AA21004. Drug Metab Dispos. 2012 Jul;40(7):1357-65. DM6F1PU RU https://www.ncbi.nlm.nih.gov/pubmed/?term=22496396 DM6F1PU DI DM6F1PU DM6F1PU DN Vortioxetine DM6F1PU MI DE4LYSA DM6F1PU MN Cytochrome P450 3A4 (CYP3A4) DM6F1PU MT DME DM6F1PU MA Metabolism DM6F1PU RN Identification of the cytochrome P450 and other enzymes involved in the in vitro oxidative metabolism of a novel antidepressant, Lu AA21004. Drug Metab Dispos. 2012 Jul;40(7):1357-65. DM6F1PU RU https://www.ncbi.nlm.nih.gov/pubmed/?term=22496396 DM6F1PU DI DM6F1PU DM6F1PU DN Vortioxetine DM6F1PU MI DEIBDNY DM6F1PU MN Cytochrome P450 3A5 (CYP3A5) DM6F1PU MT DME DM6F1PU MA Metabolism DM6F1PU RN Identification of the cytochrome P450 and other enzymes involved in the in vitro oxidative metabolism of a novel antidepressant, Lu AA21004. Drug Metab Dispos. 2012 Jul;40(7):1357-65. DM6F1PU RU https://www.ncbi.nlm.nih.gov/pubmed/?term=22496396 DM6F1PU DI DM6F1PU DM6F1PU DN Vortioxetine DM6F1PU MI DEGTFWK DM6F1PU MN Mephenytoin 4-hydroxylase (CYP2C19) DM6F1PU MT DME DM6F1PU MA Metabolism DM6F1PU RN Vortioxetine: clinical pharmacokinetics and drug interactions. Clin Pharmacokinet. 2018 Jun;57(6):673-686. DM6F1PU RU https://www.ncbi.nlm.nih.gov/pubmed/?term=29189941 DM6F1PU DI DM6F1PU DM6F1PU DN Vortioxetine DM6F1PU MI TT3ROYC DM6F1PU MN Serotonin transporter (SERT) DM6F1PU MT DTT DM6F1PU MA Inhibitor DM6F1PU RN Radium 223 dichloride for prostate cancer treatment. Drug Des Devel Ther. 2017 Sep 6;11:2643-2651. DM6F1PU RU https://pubmed.ncbi.nlm.nih.gov/28919714 DMCS6M5 DI DMCS6M5 DMCS6M5 DN Voxelotor DMCS6M5 MI DEPKLMQ DMCS6M5 MN Cytochrome P450 2B6 (CYP2B6) DMCS6M5 MT DME DMCS6M5 MA Metabolism DMCS6M5 RN FDA label of Fedratinib. The 2020 official website of the U.S. Food and Drug Administration. DMCS6M5 RU https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/212327s000lbl.pdf DMCS6M5 DI DMCS6M5 DMCS6M5 DN Voxelotor DMCS6M5 MI DE5IED8 DMCS6M5 MN Cytochrome P450 2C9 (CYP2C9) DMCS6M5 MT DME DMCS6M5 MA Metabolism DMCS6M5 RN FDA label of Fedratinib. The 2020 official website of the U.S. Food and Drug Administration. DMCS6M5 RU https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/212327s000lbl.pdf DMCS6M5 DI DMCS6M5 DMCS6M5 DN Voxelotor DMCS6M5 MI DE4LYSA DMCS6M5 MN Cytochrome P450 3A4 (CYP3A4) DMCS6M5 MT DME DMCS6M5 MA Metabolism DMCS6M5 RN FDA label of Fedratinib. The 2020 official website of the U.S. Food and Drug Administration. DMCS6M5 RU https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/212327s000lbl.pdf DMCS6M5 DI DMCS6M5 DMCS6M5 DN Voxelotor DMCS6M5 MI TTQO71U DMCS6M5 MN Hemoglobin (HB) DMCS6M5 MT DTT DMCS6M5 MA Modulator DMCS6M5 RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health Human Services. 2019 DMCS6M5 RU https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/213137s000lbl.pdf DMCS6M5 DI DMCS6M5 DMCS6M5 DN Voxelotor DMCS6M5 MI DEGTFWK DMCS6M5 MN Mephenytoin 4-hydroxylase (CYP2C19) DMCS6M5 MT DME DMCS6M5 MA Metabolism DMCS6M5 RN FDA label of Fedratinib. The 2020 official website of the U.S. Food and Drug Administration. DMCS6M5 RU https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/212327s000lbl.pdf DMAI83D DI DMAI83D DMAI83D DN Voxilaprevir DMAI83D MI DEJGDUW DMAI83D MN Cytochrome P450 1A2 (CYP1A2) DMAI83D MT DME DMAI83D MA Metabolism DMAI83D RN Management of Unique Populations with HCV Infection DMAI83D RU https://www.hcvguidelines.org/unique-populations DMAI83D DI DMAI83D DMAI83D DN Voxilaprevir DMAI83D MI DES5XRU DMAI83D MN Cytochrome P450 2C8 (CYP2C8) DMAI83D MT DME DMAI83D MA Metabolism DMAI83D RN FDA Label of Vosevi. The 2020 official website of the U.S. Food and Drug Administration. 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DMJYCVW RU https://www.ncbi.nlm.nih.gov/pubmed/?term=9248768 DMJYCVW DI DMJYCVW DMJYCVW DN Warfarin DMJYCVW MI DE5IED8 DMJYCVW MN Cytochrome P450 2C9 (CYP2C9) DMJYCVW MT DME DMJYCVW MA Metabolism DMJYCVW RN Pharmacogenomics of CYP2C9: functional and clinical considerations. J Pers Med. 2017 Dec 28;8(1). DMJYCVW RU https://www.ncbi.nlm.nih.gov/pubmed/?term=29283396 DMJYCVW DI DMJYCVW DMJYCVW DN Warfarin DMJYCVW MI DE4LYSA DMJYCVW MN Cytochrome P450 3A4 (CYP3A4) DMJYCVW MT DME DMJYCVW MA Metabolism DMJYCVW RN Contribution of three CYP3A isoforms to metabolism of R- and S-warfarin. Drug Metab Lett. 2010 Dec;4(4):213-9. DMJYCVW RU https://www.ncbi.nlm.nih.gov/pubmed/?term=20615193 DMJYCVW DI DMJYCVW DMJYCVW DN Warfarin DMJYCVW MI DEGTFWK DMJYCVW MN Mephenytoin 4-hydroxylase (CYP2C19) DMJYCVW MT DME DMJYCVW MA Metabolism DMJYCVW RN Metabolism of R- and S-warfarin by CYP2C19 into four hydroxywarfarins. Drug Metab Lett. 2012 Sep 1;6(3):157-64. DMJYCVW RU https://www.ncbi.nlm.nih.gov/pubmed/?term=23331088 DMJYCVW DI DMJYCVW DMJYCVW DN Warfarin DMJYCVW MI DT9C1TS DMJYCVW MN Organic anion transporting polypeptide 1B3 (SLCO1B3) DMJYCVW MT DTP DMJYCVW MA Substrate DMJYCVW RN Bosentan is a substrate of human OATP1B1 and OATP1B3: inhibition of hepatic uptake as the common mechanism of its interactions with cyclosporin A, rifampicin, and sildenafil. Drug Metab Dispos. 2007 Aug;35(8):1400-7. DMJYCVW RU http://www.ncbi.nlm.nih.gov/pubmed/17496208 DMJYCVW DI DMJYCVW DMJYCVW DN Warfarin DMJYCVW MI DEYWLRK DMJYCVW MN Sulfotransferase 1A1 (SULT1A1) DMJYCVW MT DME DMJYCVW MA Metabolism DMJYCVW RN Natural products isolated from Mexican medicinal plants: novel inhibitors of sulfotransferases, SULT1A1 and SULT2A1. Phytomedicine. 2001 Nov;8(6):481-8. DMJYCVW RU https://www.ncbi.nlm.nih.gov/pubmed/?term=11824526 DMJYCVW DI DMJYCVW DMJYCVW DN Warfarin DMJYCVW MI DEYGVN4 DMJYCVW MN UDP-glucuronosyltransferase 1A1 (UGT1A1) DMJYCVW MT DME DMJYCVW MA Metabolism DMJYCVW RN Assessing cytochrome P450 and UDP-glucuronosyltransferase contributions to warfarin metabolism in humans. Chem Res Toxicol. 2009 Jul;22(7):1239-45. DMJYCVW RU https://www.ncbi.nlm.nih.gov/pubmed/?term=19408964 DMJYCVW DI DMJYCVW DMJYCVW DN Warfarin DMJYCVW MI TTEUC8H DMJYCVW MN Vitamin K epoxide reductase complex 1 (VKORC1) DMJYCVW MT DTT DMJYCVW MA Inhibitor DMJYCVW RN [Oral anticoagulation and pharmacogenetics: importance in the clinical setting]. Rev Med Suisse. 2007 Sep 12;3(124):2030, 2033-4, 2036. DMJYCVW RU https://pubmed.ncbi.nlm.nih.gov/17955831 DMLHOA0 DI DMLHOA0 DMLHOA0 DN Xatral DMLHOA0 MI TTNGILX DMLHOA0 MN Adrenergic receptor alpha-1A (ADRA1A) DMLHOA0 MT DTT DMLHOA0 MA Antagonist DMLHOA0 RN Pharma & Vaccines. Product Development Pipeline. April 29 2009. DMLHOA0 RU http://en.sanofi-aventis.com/binaries/RD_Phase_III_EN_tcm28-24007.pdf DMLHOA0 DI DMLHOA0 DMLHOA0 DN Xatral DMLHOA0 MI DE4LYSA DMLHOA0 MN Cytochrome P450 3A4 (CYP3A4) DMLHOA0 MT DME DMLHOA0 MA Metabolism DMLHOA0 RN Extended-release alfuzosin hydrochloride: a new alpha-adrenergic receptor antagonist for symptomatic benign prostatic hyperplasia. Am J Geriatr Pharmacother. 2004 Mar;2(1):14-23. DMLHOA0 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=15555475 DMU8ANS DI DMU8ANS DMU8ANS DN Ximelegatran DMU8ANS MI TT6L509 DMU8ANS MN Coagulation factor IIa (F2) DMU8ANS MT DTT DMU8ANS MA Inhibitor DMU8ANS RN Emerging drugs in peripheral arterial disease. Expert Opin Emerg Drugs. 2006 Mar;11(1):75-90. 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DMAR467 RU https://pubmed.ncbi.nlm.nih.gov/7764860 DMAR467 DI DMAR467 DMAR467 DN Xylose DMAR467 MI DEMZ1HA DMAR467 MN Xylose isomerase (xylA) DMAR467 MT DME DMAR467 MA Metabolism DMAR467 RN Bacterial xylose isomerases from the mammal gut Bacteroidetes cluster function in Saccharomyces cerevisiae for effective xylose fermentation. Microb Cell Fact. 2015 May 17;14:70. DMAR467 RU https://pubmed.ncbi.nlm.nih.gov/25981595 DMDPM7R DI DMDPM7R DMDPM7R DN Y-25130 DMDPM7R MI TTNXLKE DMDPM7R MN 5-HT 3 receptor (5HT3R) DMDPM7R MT DTT DMDPM7R MA Antagonist DMDPM7R RN The antiemetic profile of Y-25130, a new selective 5-HT3 receptor antagonist. Eur J Pharmacol. 1991 Apr 24;196(3):299-305. DMDPM7R RU https://pubmed.ncbi.nlm.nih.gov/1654255 DMDPM7R DI DMDPM7R DMDPM7R DN Y-25130 DMDPM7R MI DTUGYRD DMDPM7R MN P-glycoprotein 1 (ABCB1) DMDPM7R MT DTP DMDPM7R MA Substrate DMDPM7R RN Human intestinal transporter database: QSAR modeling and virtual profiling of drug uptake, efflux and interactions. Pharm Res. 2013 Apr;30(4):996-1007. DMDPM7R RU https://doi.org/10.1007/s11095-012-0935-x DMNZCI1 DI DMNZCI1 DMNZCI1 DN YM443 DMNZCI1 MI TT1RS9F DMNZCI1 MN Acetylcholinesterase (AChE) DMNZCI1 MT DTT DMNZCI1 MA Modulator DMNZCI1 RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015 DMNZCI1 RU https://www.accessdata.fda.gov/scripts/cder/drugsatfda/ DMMP3Y2 DI DMMP3Y2 DMMP3Y2 DN Yn-968D1 DMMP3Y2 MI DTI7UX6 DMMP3Y2 MN Breast cancer resistance protein (ABCG2) DMMP3Y2 MT DTP DMMP3Y2 MA Substrate DMMP3Y2 RN Apatinib (YN968D1) reverses multidrug resistance by inhibiting the efflux function of multiple ATP-binding cassette transporters. Cancer Res. 2010 Oct 15;70(20):7981-91. DMMP3Y2 RU https://doi.org/10.1158/0008-5472.CAN-10-0111 DMMP3Y2 DI DMMP3Y2 DMMP3Y2 DN Yn-968D1 DMMP3Y2 MI TTUTJGQ DMMP3Y2 MN Vascular endothelial growth factor receptor 2 (KDR) DMMP3Y2 MT DTT DMMP3Y2 MA Inhibitor DMMP3Y2 RN YN968D1 is a novel and selective inhibitor of vascular endothelial growth factor receptor-2 tyrosine kinase with potent activity in vitro and in vivo. Cancer Sci. 2011 Jul;102(7):1374-80. DMMP3Y2 RU https://pubmed.ncbi.nlm.nih.gov/21443688 DMJCP1Y DI DMJCP1Y DMJCP1Y DN Yohimbine DMJCP1Y MI TTQ8AFT DMJCP1Y MN Adrenergic receptor Alpha-2 (ADRA2) DMJCP1Y MT DTT DMJCP1Y MA Antagonist DMJCP1Y RN Acute neurotoxicity after yohimbine ingestion by a body builder. Clin Toxicol (Phila). 2009 Sep;47(8):827-9. DMJCP1Y RU https://pubmed.ncbi.nlm.nih.gov/19640235 DMJCP1Y DI DMJCP1Y DMJCP1Y DN Yohimbine DMJCP1Y MI DECB0K3 DMJCP1Y MN Cytochrome P450 2D6 (CYP2D6) DMJCP1Y MT DME DMJCP1Y MA Metabolism DMJCP1Y RN Relationship of cytochrome P450 pharmacogenetics to the effects of yohimbine on gastrointestinal transit and catecholamines in healthy subjects. Neurogastroenterol Motil. 2008 Aug;20(8):891-9. DMJCP1Y RU https://www.ncbi.nlm.nih.gov/pubmed/?term=18433425 DMJCP1Y DI DMJCP1Y DMJCP1Y DN Yohimbine DMJCP1Y MI DE4LYSA DMJCP1Y MN Cytochrome P450 3A4 (CYP3A4) DMJCP1Y MT DME DMJCP1Y MA Metabolism DMJCP1Y RN Human sympathetic activation by alpha2-adrenergic blockade with yohimbine: bimodal, epistatic influence of cytochrome P450-mediated drug metabolism. Clin Pharmacol Ther. 2004 Aug;76(2):139-53. DMJCP1Y RU https://www.ncbi.nlm.nih.gov/pubmed/?term=15289791 DMHNQOG DI DMHNQOG DMHNQOG DN Zafirlukast DMHNQOG MI DES5XRU DMHNQOG MN Cytochrome P450 2C8 (CYP2C8) DMHNQOG MT DME DMHNQOG MA Metabolism DMHNQOG RN Pioglitazone is metabolised by CYP2C8 and CYP3A4 in vitro: potential for interactions with CYP2C8 inhibitors. Basic Clin Pharmacol Toxicol. 2006 Jul;99(1):44-51. DMHNQOG RU https://www.ncbi.nlm.nih.gov/pubmed/?term=16867170 DMHNQOG DI DMHNQOG DMHNQOG DN Zafirlukast DMHNQOG MI DE5IED8 DMHNQOG MN Cytochrome P450 2C9 (CYP2C9) DMHNQOG MT DME DMHNQOG MA Metabolism DMHNQOG RN Potential of pranlukast and zafirlukast in the inhibition of human liver cytochrome P450 enzymes. Xenobiotica. 2004 May;34(5):429-38. DMHNQOG RU https://www.ncbi.nlm.nih.gov/pubmed/?term=15370959 DMHNQOG DI DMHNQOG DMHNQOG DN Zafirlukast DMHNQOG MI DE4LYSA DMHNQOG MN Cytochrome P450 3A4 (CYP3A4) DMHNQOG MT DME DMHNQOG MA Metabolism DMHNQOG RN Fluconazole but not the CYP3A4 inhibitor, itraconazole, increases zafirlukast plasma concentrations. Eur J Clin Pharmacol. 2012 May;68(5):681-8. DMHNQOG RU https://www.ncbi.nlm.nih.gov/pubmed/?term=22108774 DMHNQOG DI DMHNQOG DMHNQOG DN Zafirlukast DMHNQOG MI TTGKOY9 DMHNQOG MN Leukotriene CysLT1 receptor (CYSLTR1) DMHNQOG MT DTT DMHNQOG MA Antagonist DMHNQOG RN Inhibitory effects of zafirlukast on respiratory bursts of human neutrophils. Drugs Exp Clin Res. 2002;28(4):133-45. DMHNQOG RU https://pubmed.ncbi.nlm.nih.gov/12512231 DMHNQOG DI DMHNQOG DMHNQOG DN Zafirlukast DMHNQOG MI DE073H6 DMHNQOG MN Prostaglandin G/H synthase 1 (COX-1) DMHNQOG MT DME DMHNQOG MA Metabolism DMHNQOG RN Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. DMHNQOG RU https://www.ncbi.nlm.nih.gov/pubmed/?term=19515014 DMH7MUV DI DMH7MUV DMH7MUV DN Zalcitabine DMH7MUV MI DE5IED8 DMH7MUV MN Cytochrome P450 2C9 (CYP2C9) DMH7MUV MT DME DMH7MUV MA Metabolism DMH7MUV RN Protease inhibitors in patients with HIV disease. Clinically important pharmacokinetic considerations. Clin Pharmacokinet. 1997 Mar;32(3):194-209. DMH7MUV RU https://www.ncbi.nlm.nih.gov/pubmed/?term=9084959 DMH7MUV DI DMH7MUV DMH7MUV DN Zalcitabine DMH7MUV MI DECB0K3 DMH7MUV MN Cytochrome P450 2D6 (CYP2D6) DMH7MUV MT DME DMH7MUV MA Metabolism DMH7MUV RN Protease inhibitors in patients with HIV disease. Clinically important pharmacokinetic considerations. Clin Pharmacokinet. 1997 Mar;32(3):194-209. DMH7MUV RU https://www.ncbi.nlm.nih.gov/pubmed/?term=9084959 DMH7MUV DI DMH7MUV DMH7MUV DN Zalcitabine DMH7MUV MI DE4LYSA DMH7MUV MN Cytochrome P450 3A4 (CYP3A4) DMH7MUV MT DME DMH7MUV MA Metabolism DMH7MUV RN Protease inhibitors in patients with HIV disease. Clinically important pharmacokinetic considerations. Clin Pharmacokinet. 1997 Mar;32(3):194-209. DMH7MUV RU https://www.ncbi.nlm.nih.gov/pubmed/?term=9084959 DMH7MUV DI DMH7MUV DMH7MUV DN Zalcitabine DMH7MUV MI DEO1IE3 DMH7MUV MN Cytochrome P450 3A43 (CYP3A43) DMH7MUV MT DME DMH7MUV MA Metabolism DMH7MUV RN Protease inhibitors in patients with HIV disease. Clinically important pharmacokinetic considerations. Clin Pharmacokinet. 1997 Mar;32(3):194-209. DMH7MUV RU https://www.ncbi.nlm.nih.gov/pubmed/?term=9084959 DMH7MUV DI DMH7MUV DMH7MUV DN Zalcitabine DMH7MUV MI DEIBDNY DMH7MUV MN Cytochrome P450 3A5 (CYP3A5) DMH7MUV MT DME DMH7MUV MA Metabolism DMH7MUV RN Protease inhibitors in patients with HIV disease. Clinically important pharmacokinetic considerations. Clin Pharmacokinet. 1997 Mar;32(3):194-209. DMH7MUV RU https://www.ncbi.nlm.nih.gov/pubmed/?term=9084959 DMH7MUV DI DMH7MUV DMH7MUV DN Zalcitabine DMH7MUV MI DERD86B DMH7MUV MN Cytochrome P450 3A7 (CYP3A7) DMH7MUV MT DME DMH7MUV MA Metabolism DMH7MUV RN Protease inhibitors in patients with HIV disease. Clinically important pharmacokinetic considerations. Clin Pharmacokinet. 1997 Mar;32(3):194-209. DMH7MUV RU https://www.ncbi.nlm.nih.gov/pubmed/?term=9084959 DMH7MUV DI DMH7MUV DMH7MUV DN Zalcitabine DMH7MUV MI TT84ETX DMH7MUV MN Human immunodeficiency virus Reverse transcriptase (HIV RT) DMH7MUV MT DTT DMH7MUV MA Inhibitor DMH7MUV RN A peptide inhibitor of HIV-1 reverse transcriptase using alpha,beta-dehydro residues: a structure-based computer model. J Biomol Struct Dyn. 1998 Oct;16(2):347-54. DMH7MUV RU https://pubmed.ncbi.nlm.nih.gov/9833673 DMH7MUV DI DMH7MUV DMH7MUV DN Zalcitabine DMH7MUV MI DTWN7FC DMH7MUV MN Multidrug resistance-associated protein 8 (ABCC11) DMH7MUV MT DTP DMH7MUV MA Substrate DMH7MUV RN MRP8, ATP-binding cassette C11 (ABCC11), is a cyclic nucleotide efflux pump and a resistance factor for fluoropyrimidines 2',3'-dideoxycytidine and 9'-(2'-phosphonylmethoxyethyl)adenine. J Biol Chem. 2003 Aug 8;278(32):29509-14. DMH7MUV RU http://www.ncbi.nlm.nih.gov/pubmed/12764137 DMH7MUV DI DMH7MUV DMH7MUV DN Zalcitabine DMH7MUV MI DTQ23VB DMH7MUV MN Organic anion transporter 1 (SLC22A6) DMH7MUV MT DTP DMH7MUV MA Substrate DMH7MUV RN Interaction of zalcitabine with human organic anion transporter 1. Pharmazie. 2006 May;61(5):491-2. DMH7MUV RU http://www.ncbi.nlm.nih.gov/pubmed/16724555 DMGFWSM DI DMGFWSM DMGFWSM DN Zaleplon DMGFWSM MI DEAWHS8 DMGFWSM MN Aldehyde oxidase (AOX1) DMGFWSM MT DME DMGFWSM MA Metabolism DMGFWSM RN Characterization of aldehyde oxidase enzyme activity in cryopreserved human hepatocytes. Drug Metab Dispos. 2012 Feb;40(2):267-75. DMGFWSM RU https://www.ncbi.nlm.nih.gov/pubmed/?term=22031625 DMGFWSM DI DMGFWSM DMGFWSM DN Zaleplon DMGFWSM MI DE4LYSA DMGFWSM MN Cytochrome P450 3A4 (CYP3A4) DMGFWSM MT DME DMGFWSM MA Metabolism DMGFWSM RN Metabolism of zaleplon by human liver: evidence for involvement of aldehyde oxidase. Xenobiotica. 2002 Oct;32(10):835-47. DMGFWSM RU https://www.ncbi.nlm.nih.gov/pubmed/?term=12419014 DMGFWSM DI DMGFWSM DMGFWSM DN Zaleplon DMGFWSM MI DEIBDNY DMGFWSM MN Cytochrome P450 3A5 (CYP3A5) DMGFWSM MT DME DMGFWSM MA Metabolism DMGFWSM RN Drug Interactions Flockhart Table DMGFWSM RU https://drug-interactions.medicine.iu.edu/Main-Table.aspx DMGFWSM DI DMGFWSM DMGFWSM DN Zaleplon DMGFWSM MI DERD86B DMGFWSM MN Cytochrome P450 3A7 (CYP3A7) DMGFWSM MT DME DMGFWSM MA Metabolism DMGFWSM RN Drug Interactions Flockhart Table DMGFWSM RU https://drug-interactions.medicine.iu.edu/Main-Table.aspx DMGFWSM DI DMGFWSM DMGFWSM DN Zaleplon DMGFWSM MI TT1MPAY DMGFWSM MN GABA(A) receptor alpha-1 (GABRA1) DMGFWSM MT DTT DMGFWSM MA Modulator DMGFWSM RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. DMGFWSM RU https://www.fda.gov/ DMFMBZ4 DI DMFMBZ4 DMFMBZ4 DN Zanamivir DMFMBZ4 MI TT50QJ3 DMFMBZ4 MN Influenza Neuraminidase (Influ NA) DMFMBZ4 MT DTT DMFMBZ4 MA Inhibitor DMFMBZ4 RN Current and future antiviral therapy of severe seasonal and avian influenza. Antiviral Res. 2008 Apr;78(1):91-102. DMFMBZ4 RU https://pubmed.ncbi.nlm.nih.gov/18328578 DMUR5NG DI DMUR5NG DMUR5NG DN Zanubrutinib DMUR5NG MI DE4LYSA DMUR5NG MN Cytochrome P450 3A4 (CYP3A4) DMUR5NG MT DME DMUR5NG MA Metabolism DMUR5NG RN FDA label of Zanubrutinib. The 2020 official website of the U.S. Food and Drug Administration. DMUR5NG RU https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/213217s000lbl.pdf DMJWRQP DI DMJWRQP DMJWRQP DN Zanubrutinib DMJWRQP MI TTGM6VW DMJWRQP MN Tyrosine-protein kinase BTK (ATK) DMJWRQP MT DTT DMJWRQP MA Inhibitor DMJWRQP RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health Human Services. 2019 DMJWRQP RU https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/213217s000lbl.pdf DMA5QPM DI DMA5QPM DMA5QPM DN Zemaira DMA5QPM MI TTA7UJC DMA5QPM MN Alpha-1-antitrypsin (SERPINA1) DMA5QPM MT DTT DMA5QPM MA Inhibitor DMA5QPM RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health Human Services. DMA5QPM RU https://www.fda.gov/vaccines-blood-biologics/approved-blood-products/zemaira DMSLJP4 DI DMSLJP4 DMSLJP4 DN Ziconotide DMSLJP4 MI DE4LYSA DMSLJP4 MN Cytochrome P450 3A4 (CYP3A4) DMSLJP4 MT DME DMSLJP4 MA Metabolism DMSLJP4 RN Integrated analysis on the physicochemical properties of dihydropyridine calcium channel blockers in grapefruit juice interactions. Curr Pharm Biotechnol. 2012 Jul;13(9):1705-17. DMSLJP4 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=22039822 DMSLJP4 DI DMSLJP4 DMSLJP4 DN Ziconotide DMSLJP4 MI TT4FDG6 DMSLJP4 MN Voltage-gated calcium channel alpha Cav2.2 (CACNA1B) DMSLJP4 MT DTT DMSLJP4 MA Blocker DMSLJP4 RN Emerging treatments for traumatic brain injury. Expert Opin Emerg Drugs. 2009 Mar;14(1):67-84. DMSLJP4 RU https://pubmed.ncbi.nlm.nih.gov/19249984 DM4KI7O DI DM4KI7O DM4KI7O DN Zidovudine DM4KI7O MI DTI7UX6 DM4KI7O MN Breast cancer resistance protein (ABCG2) DM4KI7O MT DTP DM4KI7O MA Substrate DM4KI7O RN Mammalian drug efflux transporters of the ATP binding cassette (ABC) family in multidrug resistance: A review of the past decade. Cancer Lett. 2016 Jan 1;370(1):153-64. DM4KI7O RU http://www.ncbi.nlm.nih.gov/pubmed/26499806 DM4KI7O DI DM4KI7O DM4KI7O DN Zidovudine DM4KI7O MI DEJVYAZ DM4KI7O MN Cytochrome P450 2A6 (CYP2A6) DM4KI7O MT DME DM4KI7O MA Metabolism DM4KI7O RN Summary of information on human CYP enzymes: human P450 metabolism data. Drug Metab Rev. 2002 Feb-May;34(1-2):83-448. DM4KI7O RU https://www.ncbi.nlm.nih.gov/pubmed/?term=11996015 DM4KI7O DI DM4KI7O DM4KI7O DN Zidovudine DM4KI7O MI DES5XRU DM4KI7O MN Cytochrome P450 2C8 (CYP2C8) DM4KI7O MT DME DM4KI7O MA Metabolism DM4KI7O RN Summary of information on human CYP enzymes: human P450 metabolism data. Drug Metab Rev. 2002 Feb-May;34(1-2):83-448. DM4KI7O RU https://www.ncbi.nlm.nih.gov/pubmed/?term=11996015 DM4KI7O DI DM4KI7O DM4KI7O DN Zidovudine DM4KI7O MI DE5IED8 DM4KI7O MN Cytochrome P450 2C9 (CYP2C9) DM4KI7O MT DME DM4KI7O MA Metabolism DM4KI7O RN Summary of information on human CYP enzymes: human P450 metabolism data. Drug Metab Rev. 2002 Feb-May;34(1-2):83-448. DM4KI7O RU https://www.ncbi.nlm.nih.gov/pubmed/?term=11996015 DM4KI7O DI DM4KI7O DM4KI7O DN Zidovudine DM4KI7O MI DE4LYSA DM4KI7O MN Cytochrome P450 3A4 (CYP3A4) DM4KI7O MT DME DM4KI7O MA Metabolism DM4KI7O RN The metabolism of zidovudine by human liver microsomes in vitro: formation of 3'-amino-3'-deoxythymidine. Biochem Pharmacol. 1994 Jul 19;48(2):267-76. DM4KI7O RU https://www.ncbi.nlm.nih.gov/pubmed/?term=8053924 DM4KI7O DI DM4KI7O DM4KI7O DN Zidovudine DM4KI7O MI TTGJCWZ DM4KI7O MN Fms-like tyrosine kinase 3 (FLT-3) DM4KI7O MT DTT DM4KI7O MA Binder DM4KI7O RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1807). DM4KI7O RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1807 DM4KI7O DI DM4KI7O DM4KI7O DN Zidovudine DM4KI7O MI TT84ETX DM4KI7O MN Human immunodeficiency virus Reverse transcriptase (HIV RT) DM4KI7O MT DTT DM4KI7O MA Inhibitor DM4KI7O RN Antiviral drugs in current clinical use. J Clin Virol. 2004 Jun;30(2):115-33. DM4KI7O RU https://pubmed.ncbi.nlm.nih.gov/15125867 DM4KI7O DI DM4KI7O DM4KI7O DN Zidovudine DM4KI7O MI DEGTFWK DM4KI7O MN Mephenytoin 4-hydroxylase (CYP2C19) DM4KI7O MT DME DM4KI7O MA Metabolism DM4KI7O RN Summary of information on human CYP enzymes: human P450 metabolism data. Drug Metab Rev. 2002 Feb-May;34(1-2):83-448. DM4KI7O RU https://www.ncbi.nlm.nih.gov/pubmed/?term=11996015 DM4KI7O DI DM4KI7O DM4KI7O DN Zidovudine DM4KI7O MI DTCSGPB DM4KI7O MN Multidrug resistance-associated protein 4 (ABCC4) DM4KI7O MT DTP DM4KI7O MA Substrate DM4KI7O RN Human intestinal transporter database: QSAR modeling and virtual profiling of drug uptake, efflux and interactions. Pharm Res. 2013 Apr;30(4):996-1007. DM4KI7O RU https://doi.org/10.1007/s11095-012-0935-x DM4KI7O DI DM4KI7O DM4KI7O DN Zidovudine DM4KI7O MI DTQ23VB DM4KI7O MN Organic anion transporter 1 (SLC22A6) DM4KI7O MT DTP DM4KI7O MA Substrate DM4KI7O RN Human organic anion transporters and human organic cation transporters mediate renal antiviral transport. J Pharmacol Exp Ther. 2002 Mar;300(3):918-24. DM4KI7O RU http://www.ncbi.nlm.nih.gov/pubmed/11861798 DM4KI7O DI DM4KI7O DM4KI7O DN Zidovudine DM4KI7O MI DT0OC1Q DM4KI7O MN Organic anion transporter 2 (SLC22A7) DM4KI7O MT DTP DM4KI7O MA Substrate DM4KI7O RN Human organic anion transporters and human organic cation transporters mediate renal antiviral transport. J Pharmacol Exp Ther. 2002 Mar;300(3):918-24. DM4KI7O RU http://www.ncbi.nlm.nih.gov/pubmed/11861798 DM4KI7O DI DM4KI7O DM4KI7O DN Zidovudine DM4KI7O MI DTVP67E DM4KI7O MN Organic anion transporter 3 (SLC22A8) DM4KI7O MT DTP DM4KI7O MA Substrate DM4KI7O RN Human organic anion transporters and human organic cation transporters mediate renal antiviral transport. J Pharmacol Exp Ther. 2002 Mar;300(3):918-24. DM4KI7O RU http://www.ncbi.nlm.nih.gov/pubmed/11861798 DM4KI7O DI DM4KI7O DM4KI7O DN Zidovudine DM4KI7O MI DT06JWZ DM4KI7O MN Organic anion transporter 4 (SLC22A11) DM4KI7O MT DTP DM4KI7O MA Substrate DM4KI7O RN Human organic anion transporters and human organic cation transporters mediate renal antiviral transport. J Pharmacol Exp Ther. 2002 Mar;300(3):918-24. DM4KI7O RU http://www.ncbi.nlm.nih.gov/pubmed/11861798 DM4KI7O DI DM4KI7O DM4KI7O DN Zidovudine DM4KI7O MI DTT79CX DM4KI7O MN Organic cation transporter 1 (SLC22A1) DM4KI7O MT DTP DM4KI7O MA Substrate DM4KI7O RN Human intestinal transporter database: QSAR modeling and virtual profiling of drug uptake, efflux and interactions. Pharm Res. 2013 Apr;30(4):996-1007. DM4KI7O RU https://doi.org/10.1007/s11095-012-0935-x DM4KI7O DI DM4KI7O DM4KI7O DN Zidovudine DM4KI7O MI DTUGYRD DM4KI7O MN P-glycoprotein 1 (ABCB1) DM4KI7O MT DTP DM4KI7O MA Substrate DM4KI7O RN The transport of anti-HIV drugs across blood-CNS interfaces: summary of current knowledge and recommendations for further research. Antiviral Res. 2009 May;82(2):A99-109. DM4KI7O RU https://doi.org/10.1016/j.antiviral.2008.12.013 DM4KI7O DI DM4KI7O DM4KI7O DN Zidovudine DM4KI7O MI DEYGVN4 DM4KI7O MN UDP-glucuronosyltransferase 1A1 (UGT1A1) DM4KI7O MT DME DM4KI7O MA Metabolism DM4KI7O RN Interindividual variability in pharmacokinetics of generic nucleoside reverse transcriptase inhibitors in TB/HIV-coinfected Ghanaian patients: UGT2B7*1c is associated with faster zidovudine clearance and glucuronidation. J Clin Pharmacol. 2009 Sep;49(9):1079-90. DM4KI7O RU https://www.ncbi.nlm.nih.gov/pubmed/?term=19628728 DM4KI7O DI DM4KI7O DM4KI7O DN Zidovudine DM4KI7O MI DEB3CV1 DM4KI7O MN UDP-glucuronosyltransferase 2B7 (UGT2B7) DM4KI7O MT DME DM4KI7O MA Metabolism DM4KI7O RN Determination of UDP-glucuronosyltransferase UGT2B7 activity in human liver microsomes by ultra-performance liquid chromatography with MS detection. J Chromatogr B Analyt Technol Biomed Life Sci. 2008 Jul 1;870(1):84-90. DM4KI7O RU https://www.ncbi.nlm.nih.gov/pubmed/?term=18573701 DMVRIC2 DI DMVRIC2 DMVRIC2 DN Zileuton DMVRIC2 MI TT2J34L DMVRIC2 MN Arachidonate 5-lipoxygenase (5-LOX) DMVRIC2 MT DTT DMVRIC2 MA Inhibitor DMVRIC2 RN 5-lipoxygenase inhibitor zileuton attenuates ischemic brain damage: involvement of matrix metalloproteinase 9. Neurol Res. 2009 Oct;31(8):848-52. DMVRIC2 RU https://pubmed.ncbi.nlm.nih.gov/19309543 DMVRIC2 DI DMVRIC2 DMVRIC2 DN Zileuton DMVRIC2 MI DEJGDUW DMVRIC2 MN Cytochrome P450 1A2 (CYP1A2) DMVRIC2 MT DME DMVRIC2 MA Metabolism DMVRIC2 RN Synthetic and natural compounds that interact with human cytochrome P450 1A2 and implications in drug development. Curr Med Chem. 2009;16(31):4066-218. DMVRIC2 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=19754423 DMVRIC2 DI DMVRIC2 DMVRIC2 DN Zileuton DMVRIC2 MI DE5IED8 DMVRIC2 MN Cytochrome P450 2C9 (CYP2C9) DMVRIC2 MT DME DMVRIC2 MA Metabolism DMVRIC2 RN Identification of the human liver cytochrome P450 enzymes involved in the metabolism of zileuton (ABT-077) and its N-dehydroxylated metabolite, Abbott-66193. Drug Metab Dispos. 1995 Oct;23(10):1163-74. DMVRIC2 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=8654206 DMVRIC2 DI DMVRIC2 DMVRIC2 DN Zileuton DMVRIC2 MI DE4LYSA DMVRIC2 MN Cytochrome P450 3A4 (CYP3A4) DMVRIC2 MT DME DMVRIC2 MA Metabolism DMVRIC2 RN Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. DMVRIC2 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=19515014 DMVRIC2 DI DMVRIC2 DMVRIC2 DN Zileuton DMVRIC2 MI DE073H6 DMVRIC2 MN Prostaglandin G/H synthase 1 (COX-1) DMVRIC2 MT DME DMVRIC2 MA Metabolism DMVRIC2 RN Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. DMVRIC2 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=19515014 DMVRIC2 DI DMVRIC2 DMVRIC2 DN Zileuton DMVRIC2 MI DE85D2P DMVRIC2 MN UDP-glucuronosyltransferase 1A9 (UGT1A9) DMVRIC2 MT DME DMVRIC2 MA Metabolism DMVRIC2 RN Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. DMVRIC2 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=19515014 DMZ4R3Q DI DMZ4R3Q DMZ4R3Q DN Zinc salts DMZ4R3Q MI DTD3FHQ DMZ4R3Q MN Iron-regulated transporter 1 (SLC40A1) DMZ4R3Q MT DTP DMZ4R3Q MA Substrate DMZ4R3Q RN Ferroportin-mediated iron transport: expression and regulation. Biochim Biophys Acta. 2012 Sep;1823(9):1426-33. DMZ4R3Q RU http://www.ncbi.nlm.nih.gov/pubmed/22440327 DMZ4R3Q DI DMZ4R3Q DMZ4R3Q DN Zinc salts DMZ4R3Q MI DT1BO38 DMZ4R3Q MN Zinc transporter 1 (SLC30A1) DMZ4R3Q MT DTP DMZ4R3Q MA Substrate DMZ4R3Q RN Zinc transporters ZnT1 (Slc30a1), Zip8 (Slc39a8), and Zip10 (Slc39a10) in mouse red blood cells are differentially regulated during erythroid development and by dietary zinc deficiency. J Nutr. 2008 Nov;138(11):2076-83. DMZ4R3Q RU http://www.ncbi.nlm.nih.gov/pubmed/18936201 DMZ4R3Q DI DMZ4R3Q DMZ4R3Q DN Zinc salts DMZ4R3Q MI DTYBI73 DMZ4R3Q MN Zinc transporter 10 (SLC30A10) DMZ4R3Q MT DTP DMZ4R3Q MA Substrate DMZ4R3Q RN Mutations in SLC30A10 cause parkinsonism and dystonia with hypermanganesemia, polycythemia, and chronic liver disease. Am J Hum Genet. 2012 Mar 9;90(3):467-77. DMZ4R3Q RU http://www.ncbi.nlm.nih.gov/pubmed/22341971 DMZ4R3Q DI DMZ4R3Q DMZ4R3Q DN Zinc salts DMZ4R3Q MI DTIAF6C DMZ4R3Q MN Zinc transporter 2 (SLC30A2) DMZ4R3Q MT DTP DMZ4R3Q MA Substrate DMZ4R3Q RN Compound heterozygous mutations in SLC30A2/ZnT2 results in low milk zinc concentrations: a novel mechanism for zinc deficiency in a breast-fed infant. PLoS One. 2013 May 31;8(5):e64045. DMZ4R3Q RU http://www.ncbi.nlm.nih.gov/pubmed/23741301 DMZ4R3Q DI DMZ4R3Q DMZ4R3Q DN Zinc salts DMZ4R3Q MI DTKMECW DMZ4R3Q MN Zinc transporter 3 (SLC30A3) DMZ4R3Q MT DTP DMZ4R3Q MA Substrate DMZ4R3Q RN Loss of synaptic Zn2+ transporter function increases risk of febrile seizures. Sci Rep. 2015 Dec 9;5:17816. DMZ4R3Q RU http://www.ncbi.nlm.nih.gov/pubmed/26647834 DMZ4R3Q DI DMZ4R3Q DMZ4R3Q DN Zinc salts DMZ4R3Q MI DT280XI DMZ4R3Q MN Zinc transporter 4 (SLC30A4) DMZ4R3Q MT DTP DMZ4R3Q MA Substrate DMZ4R3Q RN Mutation analysis of the zinc transporter gene SLC30A4 reveals no association with periodic catatonia on chromosome 15q15. J Neural Transm (Vienna). 2003 Nov;110(11):1329-32. DMZ4R3Q RU http://www.ncbi.nlm.nih.gov/pubmed/14628196 DMZ4R3Q DI DMZ4R3Q DMZ4R3Q DN Zinc salts DMZ4R3Q MI DTVHQT2 DMZ4R3Q MN Zinc transporter 5 (SLC30A5) DMZ4R3Q MT DTP DMZ4R3Q MA Substrate DMZ4R3Q RN Altered expression of two zinc transporters, SLC30A5 and SLC30A6, underlies a mammary gland disorder of reduced zinc secretion into milk. Genes Nutr. 2015 Sep;10(5):487. DMZ4R3Q RU http://www.ncbi.nlm.nih.gov/pubmed/26319140 DMZ4R3Q DI DMZ4R3Q DMZ4R3Q DN Zinc salts DMZ4R3Q MI DTKPRIL DMZ4R3Q MN Zinc transporter 6 (SLC30A6) DMZ4R3Q MT DTP DMZ4R3Q MA Substrate DMZ4R3Q RN Altered expression of two zinc transporters, SLC30A5 and SLC30A6, underlies a mammary gland disorder of reduced zinc secretion into milk. Genes Nutr. 2015 Sep;10(5):487. DMZ4R3Q RU http://www.ncbi.nlm.nih.gov/pubmed/26319140 DMZ4R3Q DI DMZ4R3Q DMZ4R3Q DN Zinc salts DMZ4R3Q MI DTQK38X DMZ4R3Q MN Zinc transporter 7 (SLC30A7) DMZ4R3Q MT DTP DMZ4R3Q MA Substrate DMZ4R3Q RN Znt7 (Slc30a7)-deficient mice display reduced body zinc status and body fat accumulation. J Biol Chem. 2007 Dec 21;282(51):37053-63. DMZ4R3Q RU http://www.ncbi.nlm.nih.gov/pubmed/17954933 DMZ4R3Q DI DMZ4R3Q DMZ4R3Q DN Zinc salts DMZ4R3Q MI DT7NVLY DMZ4R3Q MN Zinc transporter 8 (SLC30A8) DMZ4R3Q MT DTP DMZ4R3Q MA Substrate DMZ4R3Q RN Zinc transporter 8 (ZnT8) and cell function. Trends Endocrinol Metab. 2014 Aug;25(8):415-24. DMZ4R3Q RU http://www.ncbi.nlm.nih.gov/pubmed/24751356 DMZ4R3Q DI DMZ4R3Q DMZ4R3Q DN Zinc salts DMZ4R3Q MI DT2I79L DMZ4R3Q MN Zinc transporter 9 (SLC30A9) DMZ4R3Q MT DTP DMZ4R3Q MA Substrate DMZ4R3Q RN SLC30A9 mutation affecting intracellular zinc homeostasis causes a novel cerebro-renal syndrome. Brain. 2017 Apr 1;140(4):928-939. DMZ4R3Q RU http://www.ncbi.nlm.nih.gov/pubmed/28334855 DMZ4R3Q DI DMZ4R3Q DMZ4R3Q DN Zinc salts DMZ4R3Q MI DTDQSAM DMZ4R3Q MN Zinc transporter SLC39A7 (SLC39A7) DMZ4R3Q MT DTP DMZ4R3Q MA Substrate DMZ4R3Q RN A ZIP6-ZIP10 heteromer controls NCAM1 phosphorylation and integration into focal adhesion complexes during epithelial-to-mesenchymal transition. Sci Rep. 2017 Jan 18;7:40313. DMZ4R3Q RU http://www.ncbi.nlm.nih.gov/pubmed/28098160 DMZ4R3Q DI DMZ4R3Q DMZ4R3Q DN Zinc salts DMZ4R3Q MI DTLWPXS DMZ4R3Q MN Zinc transporter ZIP1 (SLC39A1) DMZ4R3Q MT DTP DMZ4R3Q MA Substrate DMZ4R3Q RN SLC transporters as a novel class of tumour suppressors: identity, function and molecular mechanisms. Biochem J. 2016 May 1;473(9):1113-24. DMZ4R3Q RU http://www.ncbi.nlm.nih.gov/pubmed/27118869 DMZ4R3Q DI DMZ4R3Q DMZ4R3Q DN Zinc salts DMZ4R3Q MI DTK02RZ DMZ4R3Q MN Zinc transporter ZIP10 (SLC39A10) DMZ4R3Q MT DTP DMZ4R3Q MA Substrate DMZ4R3Q RN Zinc transporter SLC39A10/ZIP10 facilitates antiapoptotic signaling during early B-cell development. Proc Natl Acad Sci U S A. 2014 Aug 12;111(32):11780-5. DMZ4R3Q RU http://www.ncbi.nlm.nih.gov/pubmed/25074913 DMZ4R3Q DI DMZ4R3Q DMZ4R3Q DN Zinc salts DMZ4R3Q MI DTEOAND DMZ4R3Q MN Zinc transporter ZIP11 (SLC39A11) DMZ4R3Q MT DTP DMZ4R3Q MA Substrate DMZ4R3Q RN Gastric and colonic zinc transporter ZIP11 (Slc39a11) in mice responds to dietary zinc and exhibits nuclear localization. J Nutr. 2013 Dec;143(12):1882-8. DMZ4R3Q RU http://www.ncbi.nlm.nih.gov/pubmed/24089422 DMZ4R3Q DI DMZ4R3Q DMZ4R3Q DN Zinc salts DMZ4R3Q MI DT1UIT5 DMZ4R3Q MN Zinc transporter ZIP12 (SLC39A12) DMZ4R3Q MT DTP DMZ4R3Q MA Substrate DMZ4R3Q RN The zinc transporter ZIP12 regulates the pulmonary vascular response to chronic hypoxia. Nature. 2015 Aug 20;524(7565):356-60. DMZ4R3Q RU http://www.ncbi.nlm.nih.gov/pubmed/26258299 DMZ4R3Q DI DMZ4R3Q DMZ4R3Q DN Zinc salts DMZ4R3Q MI DTOTKBS DMZ4R3Q MN Zinc transporter ZIP13 (SLC39A13) DMZ4R3Q MT DTP DMZ4R3Q MA Substrate DMZ4R3Q RN Promotion of vesicular zinc efflux by ZIP13 and its implications for spondylocheiro dysplastic Ehlers-Danlos syndrome. Proc Natl Acad Sci U S A. 2012 Dec 18;109(51):E3530-8. DMZ4R3Q RU http://www.ncbi.nlm.nih.gov/pubmed/23213233 DMZ4R3Q DI DMZ4R3Q DMZ4R3Q DN Zinc salts DMZ4R3Q MI DTZ6IJW DMZ4R3Q MN Zinc transporter ZIP14 (SLC39A14) DMZ4R3Q MT DTP DMZ4R3Q MA Substrate DMZ4R3Q RN SLC39A14 deficiency alters manganese homeostasis and excretion resulting in brain manganese accumulation and motor deficits in mice. Proc Natl Acad Sci U S A. 2018 Feb 20;115(8):E1769-E1778. DMZ4R3Q RU http://www.ncbi.nlm.nih.gov/pubmed/29437953 DMZ4R3Q DI DMZ4R3Q DMZ4R3Q DN Zinc salts DMZ4R3Q MI DTL8VXO DMZ4R3Q MN Zinc transporter ZIP2 (SLC39A2) DMZ4R3Q MT DTP DMZ4R3Q MA Substrate DMZ4R3Q RN Reassessment of the Transport Mechanism of the Human Zinc Transporter SLC39A2. Biochemistry. 2018 Jul 3;57(26):3976-3986. DMZ4R3Q RU http://www.ncbi.nlm.nih.gov/pubmed/29791142 DMZ4R3Q DI DMZ4R3Q DMZ4R3Q DN Zinc salts DMZ4R3Q MI DTH08M7 DMZ4R3Q MN Zinc transporter ZIP3 (SLC39A3) DMZ4R3Q MT DTP DMZ4R3Q MA Substrate DMZ4R3Q RN The SLC39 family of zinc transporters. Mol Aspects Med. 2013 Apr-Jun;34(2-3):612-9. DMZ4R3Q RU http://www.ncbi.nlm.nih.gov/pubmed/23506894 DMZ4R3Q DI DMZ4R3Q DMZ4R3Q DN Zinc salts DMZ4R3Q MI DTEZCUM DMZ4R3Q MN Zinc transporter ZIP4 (SLC39A4) DMZ4R3Q MT DTP DMZ4R3Q MA Substrate DMZ4R3Q RN Extreme population differences in the human zinc transporter ZIP4 (SLC39A4) are explained by positive selection in Sub-Saharan Africa. PLoS Genet. 2014 Feb 20;10(2):e1004128. DMZ4R3Q RU http://www.ncbi.nlm.nih.gov/pubmed/24586184 DMZ4R3Q DI DMZ4R3Q DMZ4R3Q DN Zinc salts DMZ4R3Q MI DTN9ACR DMZ4R3Q MN Zinc transporter ZIP5 (SLC39A5) DMZ4R3Q MT DTP DMZ4R3Q MA Substrate DMZ4R3Q RN The mammalian Zip5 protein is a zinc transporter that localizes to the basolateral surface of polarized cells. J Biol Chem. 2004 Dec 3;279(49):51433-41. DMZ4R3Q RU http://www.ncbi.nlm.nih.gov/pubmed/15322118 DMZ4R3Q DI DMZ4R3Q DMZ4R3Q DN Zinc salts DMZ4R3Q MI DTT1S93 DMZ4R3Q MN Zinc transporter ZIP6 (SLC39A6) DMZ4R3Q MT DTP DMZ4R3Q MA Substrate DMZ4R3Q RN A ZIP6-ZIP10 heteromer controls NCAM1 phosphorylation and integration into focal adhesion complexes during epithelial-to-mesenchymal transition. Sci Rep. 2017 Jan 18;7:40313. DMZ4R3Q RU http://www.ncbi.nlm.nih.gov/pubmed/28098160 DMZ4R3Q DI DMZ4R3Q DMZ4R3Q DN Zinc salts DMZ4R3Q MI DTLPQGT DMZ4R3Q MN Zinc transporter ZIP8 (SLC39A8) DMZ4R3Q MT DTP DMZ4R3Q MA Substrate DMZ4R3Q RN Zinc transporters ZnT1 (Slc30a1), Zip8 (Slc39a8), and Zip10 (Slc39a10) in mouse red blood cells are differentially regulated during erythroid development and by dietary zinc deficiency. J Nutr. 2008 Nov;138(11):2076-83. DMZ4R3Q RU http://www.ncbi.nlm.nih.gov/pubmed/18936201 DMZ4R3Q DI DMZ4R3Q DMZ4R3Q DN Zinc salts DMZ4R3Q MI DTJH79E DMZ4R3Q MN Zinc transporter ZIP9 (SLC39A9) DMZ4R3Q MT DTP DMZ4R3Q MA Substrate DMZ4R3Q RN A ZIP6-ZIP10 heteromer controls NCAM1 phosphorylation and integration into focal adhesion complexes during epithelial-to-mesenchymal transition. Sci Rep. 2017 Jan 18;7:40313. DMZ4R3Q RU http://www.ncbi.nlm.nih.gov/pubmed/28098160 DMK4OL7 DI DMK4OL7 DMK4OL7 DN Zinostatin stimalamer DMK4OL7 MI TTUTN1I DMK4OL7 MN Human Deoxyribonucleic acid (hDNA) DMK4OL7 MT DTT DMK4OL7 MA Modulator DMK4OL7 RN Natural products as sources of new drugs over the last 25 years. J Nat Prod. 2007 Mar;70(3):461-77. DMK4OL7 RU https://pubmed.ncbi.nlm.nih.gov/17309302 DMM58JY DI DMM58JY DMM58JY DN Ziprasidone DMM58JY MI DE4LYSA DMM58JY MN Cytochrome P450 3A4 (CYP3A4) DMM58JY MT DME DMM58JY MA Metabolism DMM58JY RN Metabolism of atypical antipsychotics: involvement of cytochrome p450 enzymes and relevance for drug-drug interactions. Curr Drug Metab. 2008 Jun;9(5):410-8. DMM58JY RU https://www.ncbi.nlm.nih.gov/pubmed/?term=18537577 DMM58JY DI DMM58JY DMM58JY DN Ziprasidone DMM58JY MI TTEX248 DMM58JY MN Dopamine D2 receptor (D2R) DMM58JY MT DTT DMM58JY MA Agonist DMM58JY RN Striatal and extrastriatal D2/D3-receptor-binding properties of ziprasidone: a positron emission tomography study with [18F]Fallypride and [11C]raclopride (D2/D3-receptor occupancy of ziprasidone). JClin Psychopharmacol. 2008 Dec;28(6):608-17. DMM58JY RU https://pubmed.ncbi.nlm.nih.gov/19011428 DMM58JY DI DMM58JY DMM58JY DN Ziprasidone DMM58JY MI TTLA931 DMM58JY MN Neuronal acetylcholine receptor alpha-7 (CHRNA7) DMM58JY MT DTT DMM58JY MA Binder DMM58JY RN The pipeline and future of drug development in schizophrenia. Mol Psychiatry. 2007 Oct;12(10):904-22. DMM58JY RU https://pubmed.ncbi.nlm.nih.gov/17667958 DMM58JY DI DMM58JY DMM58JY DN Ziprasidone DMM58JY MI DTUGYRD DMM58JY MN P-glycoprotein 1 (ABCB1) DMM58JY MT DTP DMM58JY MA Substrate DMM58JY RN Improving the prediction of the brain disposition for orally administered drugs using BDDCS. Adv Drug Deliv Rev. 2012 Jan;64(1):95-109. DMM58JY RU https://doi.org/10.1016/j.addr.2011.12.008 DMN4H2O DI DMN4H2O DMN4H2O DN Zithromax DMN4H2O MI TTUWYEA DMN4H2O MN Bacterial 50S ribosomal RNA (Bact 50S rRNA) DMN4H2O MT DTT DMN4H2O MA Modulator DMN4H2O RN The ChEMBL database in 2017. Nucleic Acids Res. 2017 Jan 4;45(D1):D945-D954. DMN4H2O RU https://www.ncbi.nlm.nih.gov/pubmed/27899562 DMN4H2O DI DMN4H2O DMN4H2O DN Zithromax DMN4H2O MI DE4LYSA DMN4H2O MN Cytochrome P450 3A4 (CYP3A4) DMN4H2O MT DME DMN4H2O MA Metabolism DMN4H2O RN Summary of information on human CYP enzymes: human P450 metabolism data. Drug Metab Rev. 2002 Feb-May;34(1-2):83-448. DMN4H2O RU https://www.ncbi.nlm.nih.gov/pubmed/?term=11996015 DMIXC7G DI DMIXC7G DMIXC7G DN Zoledronate DMIXC7G MI TTIKWV4 DMIXC7G MN Geranyltranstransferase (FDPS) DMIXC7G MT DTT DMIXC7G MA Modulator DMIXC7G RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. DMIXC7G RU https://www.fda.gov/ DMIXC7G DI DMIXC7G DMIXC7G DN Zoledronate DMIXC7G MI DTSYQGK DMIXC7G MN Multidrug resistance-associated protein 1 (ABCC1) DMIXC7G MT DTP DMIXC7G MA Substrate DMIXC7G RN Zoledronic acid is synergic with vinblastine to induce apoptosis in a multidrug resistance protein-1 dependent way: an in vitro study. Cell Biol Int. 2006 Mar;30(3):278-82. DMIXC7G RU https://doi.org/10.1016/j.cellbi.2005.11.008 DM57O90 DI DM57O90 DM57O90 DN Zolgensma DM57O90 MI TT8QL6X DM57O90 MN Survival motor neuron protein (SMN1) DM57O90 MT DTT DM57O90 RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health Human Services. DM57O90 RU https://www.fda.gov/vaccines-blood-biologics/zolgensma DM1IB4Q DI DM1IB4Q DM1IB4Q DN Zolmitriptan DM1IB4Q MI TTK8CXU DM1IB4Q MN 5-HT 1B receptor (HTR1B) DM1IB4Q MT DTT DM1IB4Q MA Modulator DM1IB4Q RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. DM1IB4Q RU https://www.fda.gov/ DM1IB4Q DI DM1IB4Q DM1IB4Q DN Zolmitriptan DM1IB4Q MI TT6MSOK DM1IB4Q MN 5-HT 1D receptor (HTR1D) DM1IB4Q MT DTT DM1IB4Q MA Modulator DM1IB4Q RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. DM1IB4Q RU https://www.fda.gov/ DM1IB4Q DI DM1IB4Q DM1IB4Q DN Zolmitriptan DM1IB4Q MI DEJGDUW DM1IB4Q MN Cytochrome P450 1A2 (CYP1A2) DM1IB4Q MT DME DM1IB4Q MA Metabolism DM1IB4Q RN In vitro metabolism of zolmitriptan in rat cytochromes induced with beta-naphthoflavone and the interaction between six drugs and zolmitriptan. Chem Biol Interact. 2003 Dec 15;146(3):263-72. DM1IB4Q RU https://www.ncbi.nlm.nih.gov/pubmed/?term=14642738 DM1IB4Q DI DM1IB4Q DM1IB4Q DN Zolmitriptan DM1IB4Q MI DERE4TU DM1IB4Q MN Monoamine oxidase type A (MAO-A) DM1IB4Q MT DME DM1IB4Q MA Metabolism DM1IB4Q RN Med-psych drug-drug interactions update. Psychosomatics. 2002 May;43(3):245-7. DM1IB4Q RU https://www.ncbi.nlm.nih.gov/pubmed/12075043 DM1IB4Q DI DM1IB4Q DM1IB4Q DN Zolmitriptan DM1IB4Q MI DTT79CX DM1IB4Q MN Organic cation transporter 1 (SLC22A1) DM1IB4Q MT DTP DM1IB4Q MA Substrate DM1IB4Q RN OCT1 mediates hepatic uptake of sumatriptan and loss-of-function OCT1 polymorphisms affect sumatriptan pharmacokinetics. Clin Pharmacol Ther. 2016 Jun;99(6):633-41. DM1IB4Q RU http://www.ncbi.nlm.nih.gov/pubmed/26659468 DM1IB4Q DI DM1IB4Q DM1IB4Q DN Zolmitriptan DM1IB4Q MI DTUGYRD DM1IB4Q MN P-glycoprotein 1 (ABCB1) DM1IB4Q MT DTP DM1IB4Q MA Substrate DM1IB4Q RN Improving the prediction of the brain disposition for orally administered drugs using BDDCS. Adv Drug Deliv Rev. 2012 Jan;64(1):95-109. DM1IB4Q RU https://doi.org/10.1016/j.addr.2011.12.008 DMWOSKJ DI DMWOSKJ DMWOSKJ DN Zolpidem DMWOSKJ MI DEJGDUW DMWOSKJ MN Cytochrome P450 1A2 (CYP1A2) DMWOSKJ MT DME DMWOSKJ MA Metabolism DMWOSKJ RN Adverse reactions to zolpidem: case reports and a review of the literature. Prim Care Companion J Clin Psychiatry. 2010;12(6). pii: PCC.09r00849. DMWOSKJ RU https://www.ncbi.nlm.nih.gov/pubmed/?term=21494350 DMWOSKJ DI DMWOSKJ DMWOSKJ DN Zolpidem DMWOSKJ MI DE5IED8 DMWOSKJ MN Cytochrome P450 2C9 (CYP2C9) DMWOSKJ MT DME DMWOSKJ MA Metabolism DMWOSKJ RN The influences of CYP2C9*1/*3 genotype on the pharmacokinetics of zolpidem. Arch Pharm Res. 2018 Sep;41(9):931-936. DMWOSKJ RU https://www.ncbi.nlm.nih.gov/pubmed/?term=30178440 DMWOSKJ DI DMWOSKJ DMWOSKJ DN Zolpidem DMWOSKJ MI DECB0K3 DMWOSKJ MN Cytochrome P450 2D6 (CYP2D6) DMWOSKJ MT DME DMWOSKJ MA Metabolism DMWOSKJ RN Effect of zolpidem on human cytochrome P450 activity, and on transport mediated by P-glycoprotein. Biopharm Drug Dispos. 2002 Dec;23(9):361-7. DMWOSKJ RU https://www.ncbi.nlm.nih.gov/pubmed/?term=12469329 DMWOSKJ DI DMWOSKJ DMWOSKJ DN Zolpidem DMWOSKJ MI DE4LYSA DMWOSKJ MN Cytochrome P450 3A4 (CYP3A4) DMWOSKJ MT DME DMWOSKJ MA Metabolism DMWOSKJ RN Zolpidem pharmacokinetics and pharmacodynamics in metabolic interactions involving CYP3A: sex as a differentiating factor. Eur J Clin Pharmacol. 2010 Sep;66(9):955. DMWOSKJ RU https://www.ncbi.nlm.nih.gov/pubmed/?term=20552178 DMWOSKJ DI DMWOSKJ DMWOSKJ DN Zolpidem DMWOSKJ MI DEIBDNY DMWOSKJ MN Cytochrome P450 3A5 (CYP3A5) DMWOSKJ MT DME DMWOSKJ MA Metabolism DMWOSKJ RN PharmGKB: A worldwide resource for pharmacogenomic information. Wiley Interdiscip Rev Syst Biol Med. 2018 Jul;10(4):e1417. (ID: PA166170041) DMWOSKJ RU https://www.pharmgkb.org/vip/PA166170041/relationships DMWOSKJ DI DMWOSKJ DMWOSKJ DN Zolpidem DMWOSKJ MI DERD86B DMWOSKJ MN Cytochrome P450 3A7 (CYP3A7) DMWOSKJ MT DME DMWOSKJ MA Metabolism DMWOSKJ RN Principles of Clinical Pharmacology (Third Edition). 2012, Pages 417-436 DMWOSKJ RU https://doi.org/10.1016/B978-0-12-385471-1.00025-8 DMWOSKJ DI DMWOSKJ DMWOSKJ DN Zolpidem DMWOSKJ MI TT1MPAY DMWOSKJ MN GABA(A) receptor alpha-1 (GABRA1) DMWOSKJ MT DTT DMWOSKJ MA Modulator DMWOSKJ RN Zolpidem, a selective GABA(A) receptor alpha1 subunit agonist, induces comparable Fos expression in oxytocinergic neurons of the hypothalamic paraventricular and accessory but not supraoptic nuclei in the rat.Brain Res Bull.2006 Dec 11;71(1-3):200-7. DMWOSKJ RU https://www.ncbi.nlm.nih.gov/pubmed/17113947 DMWOSKJ DI DMWOSKJ DMWOSKJ DN Zolpidem DMWOSKJ MI TTEX6LM DMWOSKJ MN GABA(A) receptor gamma-3 (GABRG3) DMWOSKJ MT DTT DMWOSKJ MA Modulator (allosteric modulator) DMWOSKJ RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 415). DMWOSKJ RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=415 DMWOSKJ DI DMWOSKJ DMWOSKJ DN Zolpidem DMWOSKJ MI DEGTFWK DMWOSKJ MN Mephenytoin 4-hydroxylase (CYP2C19) DMWOSKJ MT DME DMWOSKJ MA Metabolism DMWOSKJ RN Zolpidem extended-release: a single insomnia treatment option for sleep induction and sleep maintenance symptoms. Am J Ther. 2007 May-Jun;14(3):299-305. DMWOSKJ RU https://www.ncbi.nlm.nih.gov/pubmed/?term=17515707 DM0DTF7 DI DM0DTF7 DM0DTF7 DN Zonisamide DM0DTF7 MI DE8UGTM DM0DTF7 MN Aldehyde oxidase (AOX) DM0DTF7 MT DME DM0DTF7 MA Metabolism DM0DTF7 RN The role of mammalian intestinal bacteria in the reductive metabolism of zonisamide. J Pharm Pharmacol. 1997 Mar;49(3):253-6. DM0DTF7 RU https://pubmed.ncbi.nlm.nih.gov/9231340 DM0DTF7 DI DM0DTF7 DM0DTF7 DN Zonisamide DM0DTF7 MI DE4LYSA DM0DTF7 MN Cytochrome P450 3A4 (CYP3A4) DM0DTF7 MT DME DM0DTF7 MA Metabolism DM0DTF7 RN Pharmacokinetics and drug interactions with zonisamide. Epilepsia. 2007 Mar;48(3):435-41. DM0DTF7 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=17319920 DM0DTF7 DI DM0DTF7 DM0DTF7 DN Zonisamide DM0DTF7 MI DEIBDNY DM0DTF7 MN Cytochrome P450 3A5 (CYP3A5) DM0DTF7 MT DME DM0DTF7 MA Metabolism DM0DTF7 RN Prediction of drug-drug interactions of zonisamide metabolism in humans from in vitro data. Eur J Clin Pharmacol. 1998 Apr;54(2):177-83. DM0DTF7 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=9626925 DM0DTF7 DI DM0DTF7 DM0DTF7 DN Zonisamide DM0DTF7 MI DERD86B DM0DTF7 MN Cytochrome P450 3A7 (CYP3A7) DM0DTF7 MT DME DM0DTF7 MA Metabolism DM0DTF7 RN Differential catalytic properties in metabolism of endogenous and exogenous substrates among CYP3A enzymes expressed in COS-7 cells. Biochim Biophys Acta. 1998 May 8;1380(3):297-304. DM0DTF7 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=9555064 DM0DTF7 DI DM0DTF7 DM0DTF7 DN Zonisamide DM0DTF7 MI DEGTFWK DM0DTF7 MN Mephenytoin 4-hydroxylase (CYP2C19) DM0DTF7 MT DME DM0DTF7 MA Metabolism DM0DTF7 RN Carbamazepine pharmacokinetics are not affected by zonisamide: in vitro mechanistic study and in vivo clinical study in epileptic patients. Epilepsy Res. 2004 Nov;62(1):1-11. DM0DTF7 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=15519127 DM0DTF7 DI DM0DTF7 DM0DTF7 DN Zonisamide DM0DTF7 MI TTRK8B9 DM0DTF7 MN Sodium channel unspecific (NaC) DM0DTF7 MT DTT DM0DTF7 MA Blocker DM0DTF7 RN Antiepileptic drugs and relapse after epilepsy surgery. Epileptic Disord. 2008 Sep;10(3):193-8. DM0DTF7 RU https://pubmed.ncbi.nlm.nih.gov/18782687 DM0DTF7 DI DM0DTF7 DM0DTF7 DN Zonisamide DM0DTF7 MI DEYGVN4 DM0DTF7 MN UDP-glucuronosyltransferase 1A1 (UGT1A1) DM0DTF7 MT DME DM0DTF7 MA Metabolism DM0DTF7 RN Actual and Predicted Pharmacokinetic Interactions Between Anticonvulsants and Antiretrovirals. DM0DTF7 RU https://hivclinic.ca/archive/main/drugs_interact_files/anticonvulsant-int.pdf DMPI6Z0 DI DMPI6Z0 DMPI6Z0 DN Zopiclone DMPI6Z0 MI DES5XRU DMPI6Z0 MN Cytochrome P450 2C8 (CYP2C8) DMPI6Z0 MT DME DMPI6Z0 MA Metabolism DMPI6Z0 RN Cytochrome P-450 3A4 and 2C8 are involved in zopiclone metabolism. Drug Metab Dispos. 1999 Sep;27(9):1068-73. DMPI6Z0 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=10460808 DMPI6Z0 DI DMPI6Z0 DMPI6Z0 DN Zopiclone DMPI6Z0 MI DE5IED8 DMPI6Z0 MN Cytochrome P450 2C9 (CYP2C9) DMPI6Z0 MT DME DMPI6Z0 MA Metabolism DMPI6Z0 RN Cytochrome P-450 3A4 and 2C8 are involved in zopiclone metabolism. Drug Metab Dispos. 1999 Sep;27(9):1068-73. DMPI6Z0 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=10460808 DMPI6Z0 DI DMPI6Z0 DMPI6Z0 DN Zopiclone DMPI6Z0 MI DEVDYN7 DMPI6Z0 MN Cytochrome P450 2E1 (CYP2E1) DMPI6Z0 MT DME DMPI6Z0 MA Metabolism DMPI6Z0 RN Eszopiclone, a nonbenzodiazepine sedative-hypnotic agent for the treatment of transient and chronic insomnia. Clin Ther. 2006 Apr;28(4):491-516. DMPI6Z0 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=16750462 DMPI6Z0 DI DMPI6Z0 DMPI6Z0 DN Zopiclone DMPI6Z0 MI DE4LYSA DMPI6Z0 MN Cytochrome P450 3A4 (CYP3A4) DMPI6Z0 MT DME DMPI6Z0 MA Metabolism DMPI6Z0 RN Eszopiclone, a nonbenzodiazepine sedative-hypnotic agent for the treatment of transient and chronic insomnia. Clin Ther. 2006 Apr;28(4):491-516. DMPI6Z0 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=16750462 DMPI6Z0 DI DMPI6Z0 DMPI6Z0 DN Zopiclone DMPI6Z0 MI TTAN6JD DMPI6Z0 MN Glutamate receptor AMPA (GRIA) DMPI6Z0 MT DTT DMPI6Z0 MA Binder DMPI6Z0 RN Eszopiclone: its use in the treatment of insomnia. Neuropsychiatr Dis Treat. 2007 Aug;3(4):441-453. DMPI6Z0 RU https://pubmed.ncbi.nlm.nih.gov/19300573 DMPI6Z0 DI DMPI6Z0 DMPI6Z0 DN Zopiclone DMPI6Z0 MI DE073H6 DMPI6Z0 MN Prostaglandin G/H synthase 1 (COX-1) DMPI6Z0 MT DME DMPI6Z0 MA Metabolism DMPI6Z0 RN Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. DMPI6Z0 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=19515014 DMRMCXW DI DMRMCXW DMRMCXW DN Zotarolimus DMRMCXW MI TTCJG29 DMRMCXW MN Serine/threonine-protein kinase mTOR (mTOR) DMRMCXW MT DTT DMRMCXW MA Modulator DMRMCXW RN Natural products to drugs: natural product-derived compounds in clinical trials. Nat Prod Rep. 2008 Jun;25(3):475-516. DMRMCXW RU https://pubmed.ncbi.nlm.nih.gov/18497896 DMF3VXA DI DMF3VXA DMF3VXA DN Zotepine DMF3VXA MI TTJQOD7 DMF3VXA MN 5-HT 2A receptor (HTR2A) DMF3VXA MT DTT DMF3VXA MA Inhibitor DMF3VXA RN Current and novel approaches to the drug treatment of schizophrenia. J Med Chem. 2001 Feb 15;44(4):477-501. DMF3VXA RU https://pubmed.ncbi.nlm.nih.gov/11170639 DMF3VXA DI DMF3VXA DMF3VXA DN Zotepine DMF3VXA MI DE6OQ3W DMF3VXA MN Cytochrome P450 1A1 (CYP1A1) DMF3VXA MT DME DMF3VXA MA Metabolism DMF3VXA RN Identification of cytochrome P450 enzymes involved in the metabolism of zotepine, an antipsychotic drug, in human liver microsomes. Xenobiotica. 1999 Mar;29(3):217-29. DMF3VXA RU https://www.ncbi.nlm.nih.gov/pubmed/?term=10219963 DMF3VXA DI DMF3VXA DMF3VXA DN Zotepine DMF3VXA MI DEJGDUW DMF3VXA MN Cytochrome P450 1A2 (CYP1A2) DMF3VXA MT DME DMF3VXA MA Metabolism DMF3VXA RN Identification of cytochrome P450 enzymes involved in the metabolism of zotepine, an antipsychotic drug, in human liver microsomes. Xenobiotica. 1999 Mar;29(3):217-29. DMF3VXA RU https://www.ncbi.nlm.nih.gov/pubmed/?term=10219963 DMF3VXA DI DMF3VXA DMF3VXA DN Zotepine DMF3VXA MI DEPKLMQ DMF3VXA MN Cytochrome P450 2B6 (CYP2B6) DMF3VXA MT DME DMF3VXA MA Metabolism DMF3VXA RN Identification of cytochrome P450 enzymes involved in the metabolism of zotepine, an antipsychotic drug, in human liver microsomes. Xenobiotica. 1999 Mar;29(3):217-29. DMF3VXA RU https://www.ncbi.nlm.nih.gov/pubmed/?term=10219963 DMF3VXA DI DMF3VXA DMF3VXA DN Zotepine DMF3VXA MI DECB0K3 DMF3VXA MN Cytochrome P450 2D6 (CYP2D6) DMF3VXA MT DME DMF3VXA MA Metabolism DMF3VXA RN Identification of cytochrome P450 enzymes involved in the metabolism of zotepine, an antipsychotic drug, in human liver microsomes. Xenobiotica. 1999 Mar;29(3):217-29. DMF3VXA RU https://www.ncbi.nlm.nih.gov/pubmed/?term=10219963 DMF3VXA DI DMF3VXA DMF3VXA DN Zotepine DMF3VXA MI DE4LYSA DMF3VXA MN Cytochrome P450 3A4 (CYP3A4) DMF3VXA MT DME DMF3VXA MA Metabolism DMF3VXA RN New antipsychotic agents for schizophrenia: pharmacokinetics and metabolism update. Curr Opin Investig Drugs. 2002 Jul;3(7):1073-80. DMF3VXA RU https://www.ncbi.nlm.nih.gov/pubmed/?term=12186270 DMF3VXA DI DMF3VXA DMF3VXA DN Zotepine DMF3VXA MI DEIBDNY DMF3VXA MN Cytochrome P450 3A5 (CYP3A5) DMF3VXA MT DME DMF3VXA MA Metabolism DMF3VXA RN Identification of cytochrome P450 enzymes involved in the metabolism of zotepine, an antipsychotic drug, in human liver microsomes. Xenobiotica. 1999 Mar;29(3):217-29. DMF3VXA RU https://www.ncbi.nlm.nih.gov/pubmed/?term=10219963 DMF3VXA DI DMF3VXA DMF3VXA DN Zotepine DMF3VXA MI DEGTFWK DMF3VXA MN Mephenytoin 4-hydroxylase (CYP2C19) DMF3VXA MT DME DMF3VXA MA Metabolism DMF3VXA RN Identification of cytochrome P450 enzymes involved in the metabolism of zotepine, an antipsychotic drug, in human liver microsomes. Xenobiotica. 1999 Mar;29(3):217-29. DMF3VXA RU https://www.ncbi.nlm.nih.gov/pubmed/?term=10219963 DMKYD5N DI DMKYD5N DMKYD5N DN Zuclopenthixol DMKYD5N MI DECB0K3 DMKYD5N MN Cytochrome P450 2D6 (CYP2D6) DMKYD5N MT DME DMKYD5N MA Metabolism DMKYD5N RN Genotype and co-medication dependent CYP2D6 metabolic activity: effects on serum concentrations of aripiprazole, haloperidol, risperidone, paliperidone and zuclopenthixol. Eur J Clin Pharmacol. 2016 Feb;72(2):175-84. DMKYD5N RU https://www.ncbi.nlm.nih.gov/pubmed/?term=26514968 DMKYD5N DI DMKYD5N DMKYD5N DN Zuclopenthixol DMKYD5N MI TTEX248 DMKYD5N MN Dopamine D2 receptor (D2R) DMKYD5N MT DTT DMKYD5N MA Antagonist DMKYD5N RN An ethopharmacological assessment of the effects of zuclopenthixol on agonistic interactions in male mice. Methods Find Exp Clin Pharmacol. 1999 Jan-Feb;21(1):11-5. DMKYD5N RU https://pubmed.ncbi.nlm.nih.gov/10222441 DMRCOU5 DI DMRCOU5 DMRCOU5 DN Dicycloplatin DMRCOU5 MI TTUTN1I DMRCOU5 MN Human Deoxyribonucleic acid (hDNA) DMRCOU5 MT DTT DMRCOU5 MA Inhibitor DMRCOU5 RN Dicycloplatin, a novel platinum analog in chemotherapy: synthesis of chinese pre-clinical and clinical profile and emerging mechanistic studies. Anticancer Res. 2014 Jan;34(1):455-63. DMRCOU5 RU https://pubmed.ncbi.nlm.nih.gov/24403501 DMBZ27L DI DMBZ27L DMBZ27L DN Favipiravir DMBZ27L MI TT79JGK DMBZ27L MN Mycobacterium RNA polymerase (MycB RNAP) DMBZ27L MT DTT DMBZ27L MA Modulator DMBZ27L RN Favipiravir (T-705), a novel viral RNA polymerase inhibitor.Antiviral Res.2013 Nov;100(2):446-54. DMBZ27L RU https://www.ncbi.nlm.nih.gov/pubmed/24084488 DMDWYUN DI DMDWYUN DMDWYUN DN HBI-8000 DMDWYUN MI TTBH0VX DMDWYUN MN Histone deacetylase (HDAC) DMDWYUN MT DTT DMDWYUN MA Inhibitor DMDWYUN RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMDWYUN RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DMDWYUN DI DMDWYUN DMDWYUN DN HBI-8000 DMDWYUN MI TT6R7JZ DMDWYUN MN Histone deacetylase 1 (HDAC1) DMDWYUN MT DTT DMDWYUN MA Modulator DMDWYUN RN Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41. DMDWYUN RU https://www.ncbi.nlm.nih.gov/pubmed/15950434 DM5GFIK DI DM5GFIK DM5GFIK DN Icotinib hydrochloride DM5GFIK MI DEJGDUW DM5GFIK MN Cytochrome P450 1A2 (CYP1A2) DM5GFIK MT DME DM5GFIK MA Metabolism DM5GFIK RN Metabolic pathway of icotinib in vitro: the differential roles of CYP3A4, CYP3A5, and CYP1A2 on potential pharmacokinetic drug-drug interaction. J Pharm Sci. 2018 Apr;107(4):979-983. DM5GFIK RU https://www.ncbi.nlm.nih.gov/pubmed/?term=29247736 DM5GFIK DI DM5GFIK DM5GFIK DN Icotinib hydrochloride DM5GFIK MI DE4LYSA DM5GFIK MN Cytochrome P450 3A4 (CYP3A4) DM5GFIK MT DME DM5GFIK MA Metabolism DM5GFIK RN Metabolic pathway of icotinib in vitro: the differential roles of CYP3A4, CYP3A5, and CYP1A2 on potential pharmacokinetic drug-drug interaction. J Pharm Sci. 2018 Apr;107(4):979-983. DM5GFIK RU https://www.ncbi.nlm.nih.gov/pubmed/?term=29247736 DM5GFIK DI DM5GFIK DM5GFIK DN Icotinib hydrochloride DM5GFIK MI DEIBDNY DM5GFIK MN Cytochrome P450 3A5 (CYP3A5) DM5GFIK MT DME DM5GFIK MA Metabolism DM5GFIK RN Metabolic pathway of icotinib in vitro: the differential roles of CYP3A4, CYP3A5, and CYP1A2 on potential pharmacokinetic drug-drug interaction. J Pharm Sci. 2018 Apr;107(4):979-983. DM5GFIK RU https://www.ncbi.nlm.nih.gov/pubmed/?term=29247736 DM5GFIK DI DM5GFIK DM5GFIK DN Icotinib hydrochloride DM5GFIK MI TTGKNB4 DM5GFIK MN Epidermal growth factor receptor (EGFR) DM5GFIK MT DTT DM5GFIK MA Antagonist DM5GFIK RN Phase I study of icotinib hydrochloride (BPI-2009H), an oral EGFR tyrosine kinase inhibitor, in patients with advanced NSCLC and other solid tumors. Lung Cancer. 2011 Aug;73(2):195-202. DM5GFIK RU https://pubmed.ncbi.nlm.nih.gov/21144613 DM5GIWZ DI DM5GIWZ DM5GIWZ DN Mirogabalin DM5GIWZ MI TTFK1JQ DM5GIWZ MN Voltage-gated calcium channel alpha-2/delta-1 (CACNA2D1) DM5GIWZ MT DTT DM5GIWZ MA Modulator DM5GIWZ RN Efficacy and safety of mirogabalin (DS-5565) for the treatment of diabetic peripheral neuropathic pain: a randomized, double-blind, placebo- and active comparator-controlled, adaptive proof-of-concept phase 2 study. Diabetes Care. 2014 Dec;37(12):3253-61. DM5GIWZ RU https://pubmed.ncbi.nlm.nih.gov/25231896 DMY67U8 DI DMY67U8 DMY67U8 DN Trapidil DMY67U8 MI TTST7KB DMY67U8 MN Fibroblast growth factor receptor 3 (FGFR3) DMY67U8 MT DTT DMY67U8 MA Inhibitor DMY67U8 RN Emerging therapies for multiple myeloma. Expert Opin Emerg Drugs. 2009 Mar;14(1):99-127. DMY67U8 RU https://pubmed.ncbi.nlm.nih.gov/19249983 DMY67U8 DI DMY67U8 DMY67U8 DN Trapidil DMY67U8 MI TTI2WET DMY67U8 MN Platelet-derived growth factor receptor (PDGFR) DMY67U8 MT DTT DMY67U8 MA Inhibitor DMY67U8 RN Osteitis fibrosa is mediated by Platelet-Derived Growth Factor-A via a phosphoinositide 3-kinase-dependent signaling pathway in a rat model for chr... Endocrinology. 2008 Nov;149(11):5735-46. DMY67U8 RU https://pubmed.ncbi.nlm.nih.gov/18635661 DMVZL26 DI DMVZL26 DMVZL26 DN 3,4-Dihydroxycinnamic Acid DMVZL26 MI TT2J34L DMVZL26 MN Arachidonate 5-lipoxygenase (5-LOX) DMVZL26 MT DTT DMVZL26 MA Inhibitor DMVZL26 RN Phenidone protects the nigral dopaminergic neurons from LPS-induced neurotoxicity. Neurosci Lett. 2008 Nov 7;445(1):1-6. DMVZL26 RU https://pubmed.ncbi.nlm.nih.gov/18760329 DMVZL26 DI DMVZL26 DMVZL26 DN 3,4-Dihydroxycinnamic Acid DMVZL26 MI TT2AST1 DMVZL26 MN Macrophage migration inhibitory factor (MIF) DMVZL26 MT DTT DMVZL26 MA Inhibitor DMVZL26 RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMVZL26 RU https://pubmed.ncbi.nlm.nih.gov/17139284 DML6CN4 DI DML6CN4 DML6CN4 DN Acemetacin DML6CN4 MI DEB3CV1 DML6CN4 MN UDP-glucuronosyltransferase 2B7 (UGT2B7) DML6CN4 MT DME DML6CN4 MA Metabolism DML6CN4 RN Seyffart G. (1992). Drug dosage in renal insufficiency (2nd ed.). Springer Science+Business Media Dordrecht. DML6CN4 RU https://link.springer.com/content/pdf/bfm%3A978-94-011-3804-8%2F1.pdf DM4UE3K DI DM4UE3K DM4UE3K DN Acetylcarnitine DM4UE3K MI DT3HUVD DM4UE3K MN Organic cation/carnitine transporter 2 (SLC22A5) DM4UE3K MT DTP DM4UE3K MA Substrate DM4UE3K RN Cloning and functional characterization of a novel up-regulator, cartregulin, of carnitine transporter, OCTN2. Arch Biochem Biophys. 2006 Aug 1;452(1):29-37. DM4UE3K RU http://www.ncbi.nlm.nih.gov/pubmed/16839516 DM1237M DI DM1237M DM1237M DN Alfacalcidol DM1237M MI DERSX5P DM1237M MN Cytochrome P450 2J2 (CYP2J2) DM1237M MT DME DM1237M MA Metabolism DM1237M RN Characterization of rat and human CYP2J enzymes as Vitamin D 25-hydroxylases. Steroids. 2006 Oct;71(10):849-56. DM1237M RU https://www.ncbi.nlm.nih.gov/pubmed/?term=16842832 DM1237M DI DM1237M DM1237M DN Alfacalcidol DM1237M MI DEBS639 DM1237M MN Vitamin D(3) 25-hydroxylase (CYP27A1) DM1237M MT DME DM1237M MA Metabolism DM1237M RN Kidney microsomal 25- and 1alpha-hydroxylase in vitamin D metabolism: catalytic properties, molecular cloning, cellular localization and expression during development. Biochim Biophys Acta. 2002 Feb 28;1580(2-3):133-44. DM1237M RU https://www.ncbi.nlm.nih.gov/pubmed/?term=11880238 DMY2AH1 DI DMY2AH1 DMY2AH1 DN Aminophenazone DMY2AH1 MI DEJGDUW DMY2AH1 MN Cytochrome P450 1A2 (CYP1A2) DMY2AH1 MT DME DMY2AH1 MA Metabolism DMY2AH1 RN Summary of information on human CYP enzymes: human P450 metabolism data. Drug Metab Rev. 2002 Feb-May;34(1-2):83-448. DMY2AH1 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=11996015 DMY2AH1 DI DMY2AH1 DMY2AH1 DN Aminophenazone DMY2AH1 MI DEZMWRE DMY2AH1 MN Cytochrome P450 2C18 (CYP2C18) DMY2AH1 MT DME DMY2AH1 MA Metabolism DMY2AH1 RN Contribution of human hepatic cytochrome P450s and steroidogenic CYP17 to the N-demethylation of aminopyrine. Xenobiotica. 1999 Feb;29(2):187-93. DMY2AH1 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=10199594 DMY2AH1 DI DMY2AH1 DMY2AH1 DN Aminophenazone DMY2AH1 MI DES5XRU DMY2AH1 MN Cytochrome P450 2C8 (CYP2C8) DMY2AH1 MT DME DMY2AH1 MA Metabolism DMY2AH1 RN Contribution of human hepatic cytochrome P450s and steroidogenic CYP17 to the N-demethylation of aminopyrine. Xenobiotica. 1999 Feb;29(2):187-93. DMY2AH1 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=10199594 DMY2AH1 DI DMY2AH1 DMY2AH1 DN Aminophenazone DMY2AH1 MI DE5IED8 DMY2AH1 MN Cytochrome P450 2C9 (CYP2C9) DMY2AH1 MT DME DMY2AH1 MA Metabolism DMY2AH1 RN Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. DMY2AH1 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=19515014 DMY2AH1 DI DMY2AH1 DMY2AH1 DN Aminophenazone DMY2AH1 MI DECB0K3 DMY2AH1 MN Cytochrome P450 2D6 (CYP2D6) DMY2AH1 MT DME DMY2AH1 MA Metabolism DMY2AH1 RN Contribution of human hepatic cytochrome P450s and steroidogenic CYP17 to the N-demethylation of aminopyrine. Xenobiotica. 1999 Feb;29(2):187-93. DMY2AH1 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=10199594 DMY2AH1 DI DMY2AH1 DMY2AH1 DN Aminophenazone DMY2AH1 MI DE4LYSA DMY2AH1 MN Cytochrome P450 3A4 (CYP3A4) DMY2AH1 MT DME DMY2AH1 MA Metabolism DMY2AH1 RN Contribution of human hepatic cytochrome P450s and steroidogenic CYP17 to the N-demethylation of aminopyrine. Xenobiotica. 1999 Feb;29(2):187-93. DMY2AH1 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=10199594 DMY2AH1 DI DMY2AH1 DMY2AH1 DN Aminophenazone DMY2AH1 MI DERD86B DMY2AH1 MN Cytochrome P450 3A7 (CYP3A7) DMY2AH1 MT DME DMY2AH1 MA Metabolism DMY2AH1 RN Summary of information on human CYP enzymes: human P450 metabolism data. Drug Metab Rev. 2002 Feb-May;34(1-2):83-448. DMY2AH1 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=11996015 DMY2AH1 DI DMY2AH1 DMY2AH1 DN Aminophenazone DMY2AH1 MI DEGTFWK DMY2AH1 MN Mephenytoin 4-hydroxylase (CYP2C19) DMY2AH1 MT DME DMY2AH1 MA Metabolism DMY2AH1 RN Inhibition of human hepatic cytochrome P450s and steroidogenic CYP17 by nonylphenol. Biol Pharm Bull. 2002 Feb;25(2):235-8. DMY2AH1 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=11853173 DMY2AH1 DI DMY2AH1 DMY2AH1 DN Aminophenazone DMY2AH1 MI DEX2KIA DMY2AH1 MN Steroid 17-alpha-monooxygenase (CYP17A1) DMY2AH1 MT DME DMY2AH1 MA Metabolism DMY2AH1 RN Contribution of human hepatic cytochrome P450s and steroidogenic CYP17 to the N-demethylation of aminopyrine. Xenobiotica. 1999 Feb;29(2):187-93. DMY2AH1 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=10199594 DMWDEN0 DI DMWDEN0 DMWDEN0 DN Amylin DMWDEN0 MI DE0LW4X DMWDEN0 MN Matrix metalloproteinase-2 (MMP-2) DMWDEN0 MT DME DMWDEN0 MA Metabolism DMWDEN0 RN Matrix metalloproteinase-9 reduces islet amyloid formation by degrading islet amyloid polypeptide. J Biol Chem. 2013 Feb 1;288(5):3553-9. DMWDEN0 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=23229548 DMWDEN0 DI DMWDEN0 DMWDEN0 DN Amylin DMWDEN0 MI DEA0BDX DMWDEN0 MN Matrix metalloproteinase-9 (MMP-9) DMWDEN0 MT DME DMWDEN0 MA Metabolism DMWDEN0 RN Matrix metalloproteinase-9 reduces islet amyloid formation by degrading islet amyloid polypeptide. J Biol Chem. 2013 Feb 1;288(5):3553-9. DMWDEN0 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=23229548 DMWDEN0 DI DMWDEN0 DMWDEN0 DN Amylin DMWDEN0 MI TTD0CIQ DMWDEN0 MN Melanocortin receptor 4 (MC4R) DMWDEN0 MT DTT DMWDEN0 MA Agonist DMWDEN0 RN Novel anti-obesity drugs. Expert Opin Investig Drugs. 2000 Jun;9(6):1317-26. DMWDEN0 RU https://pubmed.ncbi.nlm.nih.gov/11060745 DM8EKSV DI DM8EKSV DM8EKSV DN Anti-MIF antibodies DM8EKSV MI TT2AST1 DM8EKSV MN Macrophage migration inhibitory factor (MIF) DM8EKSV MT DTT DM8EKSV MA Inhibitor DM8EKSV RN Neutralization of Macrophage Migration Inhibitory Factor (MIF) by Fully Human Antibodies Correlates with Their Specificity for the beta-Sheet Structure of MIF. J Biol Chem. 2012 March 2; 287(10): 7446-7455. DM8EKSV RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3293543/ DML1VXW DI DML1VXW DML1VXW DN Arotinolol DML1VXW MI DECB0K3 DML1VXW MN Cytochrome P450 2D6 (CYP2D6) DML1VXW MT DME DML1VXW MA Metabolism DML1VXW RN Application of substrate depletion assay to evaluation of CYP isoforms responsible for stereoselective metabolism of carvedilol. Drug Metab Pharmacokinet. 2016 Dec;31(6):425-432. DML1VXW RU https://www.ncbi.nlm.nih.gov/pubmed/?term=27836712 DMB7WYM DI DMB7WYM DMB7WYM DN ATOSIBAN DMB7WYM MI TTSCIUP DMB7WYM MN Oxytocin receptor (OTR) DMB7WYM MT DTT DMB7WYM MA Inhibitor DMB7WYM RN Pyridobenzodiazepines: a novel class of orally active, vasopressin V2 receptor selective agonists. Bioorg Med Chem Lett. 2006 Feb 15;16(4):954-9. DMB7WYM RU https://pubmed.ncbi.nlm.nih.gov/16297621 DMB7WYM DI DMB7WYM DMB7WYM DN ATOSIBAN DMB7WYM MI TT4TFGN DMB7WYM MN Vasopressin V1a receptor (V1AR) DMB7WYM MT DTT DMB7WYM MA Inhibitor DMB7WYM RN The discovery of GSK221149A: a potent and selective oxytocin antagonist. Bioorg Med Chem Lett. 2008 Jan 1;18(1):90-4. DMB7WYM RU https://pubmed.ncbi.nlm.nih.gov/18032036 DMB7WYM DI DMB7WYM DMB7WYM DN ATOSIBAN DMB7WYM MI TTL9MHW DMB7WYM MN Vasopressin V1b receptor (V1BR) DMB7WYM MT DTT DMB7WYM MA Inhibitor DMB7WYM RN The discovery of GSK221149A: a potent and selective oxytocin antagonist. Bioorg Med Chem Lett. 2008 Jan 1;18(1):90-4. DMB7WYM RU https://pubmed.ncbi.nlm.nih.gov/18032036 DMB7WYM DI DMB7WYM DMB7WYM DN ATOSIBAN DMB7WYM MI TTK8R02 DMB7WYM MN Vasopressin V2 receptor (V2R) DMB7WYM MT DTT DMB7WYM MA Inhibitor DMB7WYM RN The discovery of GSK221149A: a potent and selective oxytocin antagonist. Bioorg Med Chem Lett. 2008 Jan 1;18(1):90-4. DMB7WYM RU https://pubmed.ncbi.nlm.nih.gov/18032036 DMA12HL DI DMA12HL DMA12HL DN Azelnidipine DMA12HL MI DE4LYSA DMA12HL MN Cytochrome P450 3A4 (CYP3A4) DMA12HL MT DME DMA12HL MA Metabolism DMA12HL RN KEGG: new perspectives on genomes, pathways, diseases and drugs. Nucleic Acids Res. 2017 Jan 4;45(D1):D353-D361. (DRUG:D01145) DMA12HL RU http://www.genome.jp/dbget-bin/www_bget?D01145 DMJSDBE DI DMJSDBE DMJSDBE DN Barnidipine DMJSDBE MI DE4LYSA DMJSDBE MN Cytochrome P450 3A4 (CYP3A4) DMJSDBE MT DME DMJSDBE MA Metabolism DMJSDBE RN Examination of metabolic pathways and identification of human liver cytochrome P450 isozymes responsible for the metabolism of barnidipine, a calcium channel blocker. Xenobiotica. 1997 Sep;27(9):885-900. DMJSDBE RU https://www.ncbi.nlm.nih.gov/pubmed/?term=9381730 DMLKUG7 DI DMLKUG7 DMLKUG7 DN Beclabuvir DMLKUG7 MI DE4LYSA DMLKUG7 MN Cytochrome P450 3A4 (CYP3A4) DMLKUG7 MT DME DMLKUG7 MA Metabolism DMLKUG7 RN Application of static models to predict midazolam clinical interactions in the presence of single or multiple hepatitis C virus drugs. Drug Metab Dispos. 2016 Aug;44(8):1372-80. DMLKUG7 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=27226352 DM5NW1E DI DM5NW1E DM5NW1E DN Beclomethasone dipropionate DM5NW1E MI DTUGYRD DM5NW1E MN P-glycoprotein 1 (ABCB1) DM5NW1E MT DTP DM5NW1E MA Substrate DM5NW1E RN Oral and inhaled corticosteroids: differences in P-glycoprotein (ABCB1) mediated efflux. Toxicol Appl Pharmacol. 2012 May 1;260(3):294-302. DM5NW1E RU https://doi.org/10.1016/j.taap.2012.03.008 DMWNP6B DI DMWNP6B DMWNP6B DN Benidipine DMWNP6B MI DE4LYSA DMWNP6B MN Cytochrome P450 3A4 (CYP3A4) DMWNP6B MT DME DMWNP6B MA Metabolism DMWNP6B RN Characterization of benidipine and its enantiomers' metabolism by human liver cytochrome P450 enzymes. Drug Metab Dispos. 2007 Sep;35(9):1518-24. DMWNP6B RU https://www.ncbi.nlm.nih.gov/pubmed/?term=17537876 DMWNP6B DI DMWNP6B DMWNP6B DN Benidipine DMWNP6B MI DEIBDNY DMWNP6B MN Cytochrome P450 3A5 (CYP3A5) DMWNP6B MT DME DMWNP6B MA Metabolism DMWNP6B RN Characterization of benidipine and its enantiomers' metabolism by human liver cytochrome P450 enzymes. Drug Metab Dispos. 2007 Sep;35(9):1518-24. DMWNP6B RU https://www.ncbi.nlm.nih.gov/pubmed/?term=17537876 DMHKZX1 DI DMHKZX1 DMHKZX1 DN Benzethonium DMHKZX1 MI DECB0K3 DMHKZX1 MN Cytochrome P450 2D6 (CYP2D6) DMHKZX1 MT DME DMHKZX1 MA Metabolism DMHKZX1 RN Transport, metabolism, and in vivo population pharmacokinetics of the chloro benztropine analogs, a class of compounds extensively evaluated in animal models of drug abuse. J Pharmacol Exp Ther. 2007 Jan;320(1):344-53. DMHKZX1 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=17003230 DMHKZX1 DI DMHKZX1 DMHKZX1 DN Benzethonium DMHKZX1 MI DEGTFWK DMHKZX1 MN Mephenytoin 4-hydroxylase (CYP2C19) DMHKZX1 MT DME DMHKZX1 MA Metabolism DMHKZX1 RN Transport, metabolism, and in vivo population pharmacokinetics of the chloro benztropine analogs, a class of compounds extensively evaluated in animal models of drug abuse. J Pharmacol Exp Ther. 2007 Jan;320(1):344-53. DMHKZX1 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=17003230 DML634R DI DML634R DML634R DN Beraprost DML634R MI DES5XRU DML634R MN Cytochrome P450 2C8 (CYP2C8) DML634R MT DME DML634R MA Metabolism DML634R RN Evaluation of drug-drug interaction potential of beraprost sodium mediated by P450 in vitro. Yakugaku Zasshi. 2008 Oct;128(10):1459-65. DML634R RU https://www.ncbi.nlm.nih.gov/pubmed/?term=18827466 DMWL182 DI DMWL182 DMWL182 DN Beraprost DMWL182 MI TTOFYT1 DMWL182 MN Prostacyclin receptor (PTGIR) DMWL182 MT DTT DMWL182 MA Agonist DMWL182 RN Prostaglandin I2 IP Receptor Agonist, Beraprost, Prevents Transient Global Cerebral Ischemia Induced Hippocampal CA1 Injury in Aging Mice. J Neurol Disord. 2014;2:1000174. DMWL182 RU https://pubmed.ncbi.nlm.nih.gov/25584359 DMC5Q8X DI DMC5Q8X DMC5Q8X DN Berberine DMC5Q8X MI DTT79CX DMC5Q8X MN Organic cation transporter 1 (SLC22A1) DMC5Q8X MT DTP DMC5Q8X MA Substrate DMC5Q8X RN Vectorial transport of the plant alkaloid berberine by double-transfected cells expressing the human organic cation transporter 1 (OCT1, SLC22A1) and the efflux pump MDR1 P-glycoprotein (ABCB1). Naunyn Schmiedebergs Arch Pharmacol. 2008 Feb;376(6):449-61. DMC5Q8X RU https://doi.org/10.1007/s00210-007-0219-x DMC5Q8X DI DMC5Q8X DMC5Q8X DN Berberine DMC5Q8X MI DTUGYRD DMC5Q8X MN P-glycoprotein 1 (ABCB1) DMC5Q8X MT DTP DMC5Q8X MA Substrate DMC5Q8X RN P-glycoprotein-mediated transport of berberine across Caco-2 cell monolayers. J Pharm Sci. 2002 Dec;91(12):2614-21. DMC5Q8X RU http://www.ncbi.nlm.nih.gov/pubmed/12434406 DMC5Q8X DI DMC5Q8X DMC5Q8X DN Berberine DMC5Q8X MI TTUJFD0 DMC5Q8X MN Telomerase reverse transcriptase (TERT) DMC5Q8X MT DTT DMC5Q8X MA Inhibitor DMC5Q8X RN Stage specificity of Plasmodium falciparum telomerase and its inhibition by berberine. Parasitol Int. 2002 Mar;51(1):99-103. DMC5Q8X RU https://pubmed.ncbi.nlm.nih.gov/11880232 DMGXD5T DI DMGXD5T DMGXD5T DN Brotizolam DMGXD5T MI DE4LYSA DMGXD5T MN Cytochrome P450 3A4 (CYP3A4) DMGXD5T MT DME DMGXD5T MA Metabolism DMGXD5T RN Inhibition of the metabolism of brotizolam by erythromycin in humans: in vivo evidence for the involvement of CYP3A4 in brotizolam metabolism. Br J Clin Pharmacol. 2005 Aug;60(2):172-5. DMGXD5T RU https://www.ncbi.nlm.nih.gov/pubmed/?term=16042670 DMXZU73 DI DMXZU73 DMXZU73 DN Carbapenem DMXZU73 MI DESIWFO DMXZU73 MN Beta-lactamase (blaB) DMXZU73 MT DME DMXZU73 MA Metabolism DMXZU73 RN EBR-1, a novel Ambler subclass B1 beta-lactamase from Empedobacter brevis. Antimicrob Agents Chemother. 2002 Oct;46(10):3223-7. DMXZU73 RU https://pubmed.ncbi.nlm.nih.gov/12234848 DMXZU73 DI DMXZU73 DMXZU73 DN Carbapenem DMXZU73 MI DEBKS91 DMXZU73 MN Beta-lactamase (blaB) DMXZU73 MT DME DMXZU73 MA Metabolism DMXZU73 RN Investigation of carbapenemases and aminoglycoside modifying enzymes of Acinetobacter baumannii isolates recovered from patients admitted to intensive care units in a tertiary-care hospital in Brazil. Rev Soc Bras Med Trop. 2019 Dec 20;53:e20190044. DMXZU73 RU https://pubmed.ncbi.nlm.nih.gov/31859941 DMJKWPZ DI DMJKWPZ DMJKWPZ DN Cefpirome DMJKWPZ MI DEEAL81 DMJKWPZ MN Beta-lactamase (blaB) DMJKWPZ MT DME DMJKWPZ MA Metabolism DMJKWPZ RN Oral streptococcal strains isolated from odontogenic infections and their susceptibility to antibiotics. Rev Med Chir Soc Med Nat Iasi. 2006 Oct-Dec;110(4):1012-5. DMJKWPZ RU https://pubmed.ncbi.nlm.nih.gov/17438917 DMJKWPZ DI DMJKWPZ DMJKWPZ DN Cefpirome DMJKWPZ MI DEMIUB2 DMJKWPZ MN Beta-lactamase (blaB) DMJKWPZ MT DME DMJKWPZ MA Metabolism DMJKWPZ RN Oral streptococcal strains isolated from odontogenic infections and their susceptibility to antibiotics. Rev Med Chir Soc Med Nat Iasi. 2006 Oct-Dec;110(4):1012-5. DMJKWPZ RU https://pubmed.ncbi.nlm.nih.gov/17438917 DMPZTRC DI DMPZTRC DMPZTRC DN Ceftazidine DMPZTRC MI DEBKS91 DMPZTRC MN Beta-lactamase (blaB) DMPZTRC MT DME DMPZTRC MA Metabolism DMPZTRC RN Drug-resistant genes carried by Acinetobacter baumanii isolated from patients with lower respiratory tract infection. Chin Med J (Engl). 2010 Sep;123(18):2571-5. DMPZTRC RU https://pubmed.ncbi.nlm.nih.gov/21034630 DMYGEH7 DI DMYGEH7 DMYGEH7 DN Ceftolozane sulfate DMYGEH7 MI TTJP4SM DMYGEH7 MN Bacterial Penicillin binding protein (Bact PBP) DMYGEH7 MT DTT DMYGEH7 MA Modulator DMYGEH7 RN Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41. DMYGEH7 RU https://www.ncbi.nlm.nih.gov/pubmed/15950434 DMYTGW0 DI DMYTGW0 DMYTGW0 DN Celiprolol DMYTGW0 MI DECB0K3 DMYTGW0 MN Cytochrome P450 2D6 (CYP2D6) DMYTGW0 MT DME DMYTGW0 MA Metabolism DMYTGW0 RN Application of substrate depletion assay to evaluation of CYP isoforms responsible for stereoselective metabolism of carvedilol. Drug Metab Pharmacokinet. 2016 Dec;31(6):425-432. DMYTGW0 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=27836712 DM6C4YJ DI DM6C4YJ DM6C4YJ DN Chlorphenamine DM6C4YJ MI DECB0K3 DM6C4YJ MN Cytochrome P450 2D6 (CYP2D6) DM6C4YJ MT DME DM6C4YJ MA Metabolism DM6C4YJ RN The roles of CYP2D6 and stereoselectivity in the clinical pharmacokinetics of chlorpheniramine. Br J Clin Pharmacol. 2002 May;53(5):519-25. DM6C4YJ RU https://www.ncbi.nlm.nih.gov/pubmed/?term=11994058 DM6C4YJ DI DM6C4YJ DM6C4YJ DN Chlorphenamine DM6C4YJ MI DE4LYSA DM6C4YJ MN Cytochrome P450 3A4 (CYP3A4) DM6C4YJ MT DME DM6C4YJ MA Metabolism DM6C4YJ RN Drug Interactions Flockhart Table DM6C4YJ RU https://drug-interactions.medicine.iu.edu/Main-Table.aspx DM6C4YJ DI DM6C4YJ DM6C4YJ DN Chlorphenamine DM6C4YJ MI DEIBDNY DM6C4YJ MN Cytochrome P450 3A5 (CYP3A5) DM6C4YJ MT DME DM6C4YJ MA Metabolism DM6C4YJ RN Drug Interactions Flockhart Table DM6C4YJ RU https://drug-interactions.medicine.iu.edu/Main-Table.aspx DM6C4YJ DI DM6C4YJ DM6C4YJ DN Chlorphenamine DM6C4YJ MI DERD86B DM6C4YJ MN Cytochrome P450 3A7 (CYP3A7) DM6C4YJ MT DME DM6C4YJ MA Metabolism DM6C4YJ RN Drug Interactions Flockhart Table DM6C4YJ RU https://drug-interactions.medicine.iu.edu/Main-Table.aspx DM0N19Y DI DM0N19Y DM0N19Y DN Chondroitin sulfate DM0N19Y MI DELTYX6 DM0N19Y MN Alpha-L-iduronidase (IDUA) DM0N19Y MT DME DM0N19Y MA Metabolism DM0N19Y RN MFN human ref: Chondroitin sulfate degradation. DM0N19Y RU http://mummichog.org/shuzhao/mfn1.9/humanpngs2/mfn1v9path123.png DM0N19Y DI DM0N19Y DM0N19Y DN Chondroitin sulfate DM0N19Y MI DEHKRDS DM0N19Y MN Arylsulfatase B (ARSB) DM0N19Y MT DME DM0N19Y MA Metabolism DM0N19Y RN MFN human ref: Chondroitin sulfate degradation. DM0N19Y RU http://mummichog.org/shuzhao/mfn1.9/humanpngs2/mfn1v9path123.png DM0N19Y DI DM0N19Y DM0N19Y DN Chondroitin sulfate DM0N19Y MI DEP54UE DM0N19Y MN Beta-glucuronidase (GUSB) DM0N19Y MT DME DM0N19Y MA Metabolism DM0N19Y RN MFN human ref: Chondroitin sulfate degradation. DM0N19Y RU http://mummichog.org/shuzhao/mfn1.9/humanpngs2/mfn1v9path123.png DM0N19Y DI DM0N19Y DM0N19Y DN Chondroitin sulfate DM0N19Y MI DEQIZP2 DM0N19Y MN Chondroitin 6-sulfotransferase (CHST3) DM0N19Y MT DME DM0N19Y MA Metabolism DM0N19Y RN Variants in chondroitin sulfate metabolism genes in thrombotic storm. Thromb Res. 2018 Jan;161:43-51. DM0N19Y RU https://pubmed.ncbi.nlm.nih.gov/29178990 DM0N19Y DI DM0N19Y DM0N19Y DN Chondroitin sulfate DM0N19Y MI DEH31BC DM0N19Y MN Hyaluronate lyase (hyaL) DM0N19Y MT DME DM0N19Y MA Metabolism DM0N19Y RN nan DM0N19Y RU nan DM0N19Y DI DM0N19Y DM0N19Y DN Chondroitin sulfate DM0N19Y MI DEV7UZD DM0N19Y MN Hyaluronoglucosaminidase (nagH) DM0N19Y MT DME DM0N19Y MA Metabolism DM0N19Y RN nan DM0N19Y RU nan DM0N19Y DI DM0N19Y DM0N19Y DN Chondroitin sulfate DM0N19Y MI DEL45C2 DM0N19Y MN Iduronate 2-sulfatase (IDS) DM0N19Y MT DME DM0N19Y MA Metabolism DM0N19Y RN MFN human ref: Chondroitin sulfate degradation. DM0N19Y RU http://mummichog.org/shuzhao/mfn1.9/humanpngs2/mfn1v9path123.png DM0N19Y DI DM0N19Y DM0N19Y DN Chondroitin sulfate DM0N19Y MI DE6AY40 DM0N19Y MN N-acetyl-beta-glucosaminidase beta (HEXB) DM0N19Y MT DME DM0N19Y MA Metabolism DM0N19Y RN MFN human ref: Chondroitin sulfate degradation. DM0N19Y RU http://mummichog.org/shuzhao/mfn1.9/humanpngs2/mfn1v9path123.png DMBG0N4 DI DMBG0N4 DMBG0N4 DN Cibenzoline DMBG0N4 MI DECB0K3 DMBG0N4 MN Cytochrome P450 2D6 (CYP2D6) DMBG0N4 MT DME DMBG0N4 MA Metabolism DMBG0N4 RN Stereoselective metabolism of cibenzoline, an antiarrhythmic drug, by human and rat liver microsomes: possible involvement of CYP2D and CYP3A. Drug Metab Dispos. 2000 Sep;28(9):1128-34. DMBG0N4 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=10950860 DMBG0N4 DI DMBG0N4 DMBG0N4 DN Cibenzoline DMBG0N4 MI DE4LYSA DMBG0N4 MN Cytochrome P450 3A4 (CYP3A4) DMBG0N4 MT DME DMBG0N4 MA Metabolism DMBG0N4 RN Stereoselective metabolism of cibenzoline, an antiarrhythmic drug, by human and rat liver microsomes: possible involvement of CYP2D and CYP3A. Drug Metab Dispos. 2000 Sep;28(9):1128-34. DMBG0N4 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=10950860 DMSW5QP DI DMSW5QP DMSW5QP DN Cotrimoxazole DMSW5QP MI DEP0IWS DMSW5QP MN Beta-lactamase (blaB) DMSW5QP MT DME DMSW5QP MA Metabolism DMSW5QP RN Analysis of the drug-resistant characteristics of Klebsiella pneumoniae isolated from the respiratory tract and CTX-M ESBL genes. Genet Mol Res. 2015 Oct 5;14(4):12043-8. DMSW5QP RU https://pubmed.ncbi.nlm.nih.gov/26505351 DMLMOIJ DI DMLMOIJ DMLMOIJ DN Cyproterone acetate DMLMOIJ MI DE4LYSA DMLMOIJ MN Cytochrome P450 3A4 (CYP3A4) DMLMOIJ MT DME DMLMOIJ MA Metabolism DMLMOIJ RN Progestogens in menopausal hormone therapy. Prz Menopauzalny. 2015 Jun;14(2):134-43. DMLMOIJ RU https://www.ncbi.nlm.nih.gov/pubmed/?term=26327902 DMV6KFY DI DMV6KFY DMV6KFY DN Dapoxetine DMV6KFY MI DECB0K3 DMV6KFY MN Cytochrome P450 2D6 (CYP2D6) DMV6KFY MT DME DMV6KFY MA Metabolism DMV6KFY RN Dapoxetine: a new option in the medical management of premature ejaculation. Ther Adv Urol. 2012 Oct;4(5):233-51. DMV6KFY RU https://www.ncbi.nlm.nih.gov/pubmed/?term=23024705 DMV6KFY DI DMV6KFY DMV6KFY DN Dapoxetine DMV6KFY MI DE4LYSA DMV6KFY MN Cytochrome P450 3A4 (CYP3A4) DMV6KFY MT DME DMV6KFY MA Metabolism DMV6KFY RN Pharmacokinetics of single and multiple escalating doses of dapoxetine in healthy volunteers. Clinical Pharmacology Therapeutics, 2004, 75(2):P32. DMV6KFY RU https://ascpt.onlinelibrary.wiley.com/doi/abs/10.1016/j.clpt.2003.11.123 DMV6KFY DI DMV6KFY DMV6KFY DN Dapoxetine DMV6KFY MI DEJ73Q9 DMV6KFY MN Dimethylaniline oxidase 1 (FMO1) DMV6KFY MT DME DMV6KFY MA Metabolism DMV6KFY RN Pharmacokinetics of single and multiple escalating doses of dapoxetine in healthy volunteers. Clinical Pharmacology Therapeutics, 2004, 75(2):P32. DMV6KFY RU https://ascpt.onlinelibrary.wiley.com/doi/abs/10.1016/j.clpt.2003.11.123 DMV5KTJ DI DMV5KTJ DMV5KTJ DN Demegestone DMV5KTJ MI DE4LYSA DMV5KTJ MN Cytochrome P450 3A4 (CYP3A4) DMV5KTJ MT DME DMV5KTJ MA Metabolism DMV5KTJ RN Drug interactions between rifamycin antibiotics and hormonal contraception: a systematic review. BJOG. 2018 Jun;125(7):804-811. DMV5KTJ RU https://www.ncbi.nlm.nih.gov/pubmed/?term=29130574 DMN2Q5I DI DMN2Q5I DMN2Q5I DN Diacerein DMN2Q5I MI TTRYK0X DMN2Q5I MN Interleukin-1 beta (IL1B) DMN2Q5I MT DTT DMN2Q5I MA Inhibitor DMN2Q5I RN Non-surgical treatment of osteoarthritis of large joints - new aspects. Wien Med Wochenschr. 2009;159(3-4):76-86. DMN2Q5I RU https://pubmed.ncbi.nlm.nih.gov/19247594 DMTX0PZ DI DMTX0PZ DMTX0PZ DN Dibekacin DMTX0PZ MI DE5WGIM DMTX0PZ MN Aminoglycoside phosphotransferase (aph-Ib) DMTX0PZ MT DME DMTX0PZ MA Metabolism DMTX0PZ RN Novel aminoglycoside 2''-phosphotransferase identified in a gram-negative pathogen. Antimicrob Agents Chemother. 2013 Jan;57(1):452-7. DMTX0PZ RU https://pubmed.ncbi.nlm.nih.gov/23129050 DMZ5Y1P DI DMZ5Y1P DMZ5Y1P DN Dichloroacetate DMZ5Y1P MI TTCZOF2 DMZ5Y1P MN Pyruvate dehydrogenase kinase 1 (PDHK1) DMZ5Y1P MT DTT DMZ5Y1P MA Inhibitor DMZ5Y1P RN Comparison of Antitumor Effects of Combined and Separate Treatment with NO Synthase Inhibitor T1023 and PDK1 Inhibitor Dichloroacetate. Bull Exp Biol Med. 2019 Nov;168(1):92-94. DMZ5Y1P RU https://pubmed.ncbi.nlm.nih.gov/31768777 DMB0FWL DI DMB0FWL DMB0FWL DN Dihydrocodeine DMB0FWL MI DECB0K3 DMB0FWL MN Cytochrome P450 2D6 (CYP2D6) DMB0FWL MT DME DMB0FWL MA Metabolism DMB0FWL RN The role of active metabolites in dihydrocodeine effects. Int J Clin Pharmacol Ther. 2003 Mar;41(3):95-106. DMB0FWL RU https://www.ncbi.nlm.nih.gov/pubmed/?term=12665158 DMB0FWL DI DMB0FWL DMB0FWL DN Dihydrocodeine DMB0FWL MI DE4LYSA DMB0FWL MN Cytochrome P450 3A4 (CYP3A4) DMB0FWL MT DME DMB0FWL MA Metabolism DMB0FWL RN Pharmacokinetics of dihydrocodeine and its active metabolite after single and multiple oral dosing. Br J Clin Pharmacol. 1999 Sep;48(3):317-22. DMB0FWL RU https://www.ncbi.nlm.nih.gov/pubmed/?term=10510141 DMB0FWL DI DMB0FWL DMB0FWL DN Dihydrocodeine DMB0FWL MI TTN4QDT DMB0FWL MN Opioid receptor (OPR) DMB0FWL MT DTT DMB0FWL MA Modulator DMB0FWL RN Affinities of dihydrocodeine and its metabolites to opioid receptors. Pharmacol Toxicol. 2002 Aug;91(2):57-63. DMB0FWL RU https://pubmed.ncbi.nlm.nih.gov/12420793 DMB0FWL DI DMB0FWL DMB0FWL DN Dihydrocodeine DMB0FWL MI DENUPDX DMB0FWL MN UDP-glucuronosyltransferase 2B4 (UGT2B4) DMB0FWL MT DME DMB0FWL MA Metabolism DMB0FWL RN Adult and infant pharmacokinetic profiling of dihydrocodeine using physiologically based pharmacokinetic modeling. Biopharm Drug Dispos. 2019 Nov;40(9):350-357. DMB0FWL RU https://www.ncbi.nlm.nih.gov/pubmed/?term=31691978 DMB0FWL DI DMB0FWL DMB0FWL DN Dihydrocodeine DMB0FWL MI DEB3CV1 DMB0FWL MN UDP-glucuronosyltransferase 2B7 (UGT2B7) DMB0FWL MT DME DMB0FWL MA Metabolism DMB0FWL RN Adult and infant pharmacokinetic profiling of dihydrocodeine using physiologically based pharmacokinetic modeling. Biopharm Drug Dispos. 2019 Nov;40(9):350-357. DMB0FWL RU https://www.ncbi.nlm.nih.gov/pubmed/?term=31691978 DM3S8XC DI DM3S8XC DM3S8XC DN Dihydrotestosterone DM3S8XC MI DE7P2FB DM3S8XC MN Aldo-keto reductase 1C1 (AKR1C1) DM3S8XC MT DME DM3S8XC MA Metabolism DM3S8XC RN Human 3-alpha hydroxysteroid dehydrogenase type 3 (3alpha-HSD3): the V54L mutation restricting the steroid alternative binding and enhancing the 20alpha-HSD activity. J Steroid Biochem Mol Biol. 2014 May;141:135-43. DM3S8XC RU https://www.ncbi.nlm.nih.gov/pubmed/?term=24434280 DM3S8XC DI DM3S8XC DM3S8XC DN Dihydrotestosterone DM3S8XC MI TTS64P2 DM3S8XC MN Androgen receptor (AR) DM3S8XC MT DTT DM3S8XC MA Modulator DM3S8XC RN Inhibition of the dihydrotestosterone-activated androgen receptor by nuclear receptor corepressor. Mol Endocrinol. 2002 Jul;16(7):1492-501. DM3S8XC RU https://www.ncbi.nlm.nih.gov/pubmed/12089345 DM3S8XC DI DM3S8XC DM3S8XC DN Dihydrotestosterone DM3S8XC MI TTKPW01 DM3S8XC MN Androgen receptor messenger RNA (AR mRNA) DM3S8XC MT DTT DM3S8XC MA Agonist DM3S8XC RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 628). DM3S8XC RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=628 DM3S8XC DI DM3S8XC DM3S8XC DN Dihydrotestosterone DM3S8XC MI DEQX145 DM3S8XC MN Aromatase (CYP19A1) DM3S8XC MT DME DM3S8XC MA Metabolism DM3S8XC RN Identifying susceptibility genes for prostate cancer--a family-based association study of polymorphisms in CYP17, CYP19, CYP11A1, and LH-beta. Cancer Epidemiol Biomarkers Prev. 2005 Aug;14(8):2035-9. DM3S8XC RU https://www.ncbi.nlm.nih.gov/pubmed/?term=16103457 DM3S8XC DI DM3S8XC DM3S8XC DN Dihydrotestosterone DM3S8XC MI DTUGYRD DM3S8XC MN P-glycoprotein 1 (ABCB1) DM3S8XC MT DTP DM3S8XC MA Substrate DM3S8XC RN P-glycoprotein increases the efflux of the androgen dihydrotestosterone and reduces androgen responsive gene activity in prostate tumor cells. Prostate. 2004 Apr 1;59(1):77-90. DM3S8XC RU https://doi.org/10.1002/pros.10354 DM3S8XC DI DM3S8XC DM3S8XC DN Dihydrotestosterone DM3S8XC MI DEX2KIA DM3S8XC MN Steroid 17-alpha-monooxygenase (CYP17A1) DM3S8XC MT DME DM3S8XC MA Metabolism DM3S8XC RN Identifying susceptibility genes for prostate cancer--a family-based association study of polymorphisms in CYP17, CYP19, CYP11A1, and LH-beta. Cancer Epidemiol Biomarkers Prev. 2005 Aug;14(8):2035-9. DM3S8XC RU https://www.ncbi.nlm.nih.gov/pubmed/?term=16103457 DM3S8XC DI DM3S8XC DM3S8XC DN Dihydrotestosterone DM3S8XC MI DEYGVN4 DM3S8XC MN UDP-glucuronosyltransferase 1A1 (UGT1A1) DM3S8XC MT DME DM3S8XC MA Metabolism DM3S8XC RN UDP-glucuronosyltransferase 2B15 (UGT2B15) and UGT2B17 enzymes are major determinants of the androgen response in prostate cancer LNCaP cells. J Biol Chem. 2007 Nov 16;282(46):33466-74. DM3S8XC RU https://www.ncbi.nlm.nih.gov/pubmed/?term=17848572 DM3YH4I DI DM3YH4I DM3YH4I DN D-Serine DM3YH4I MI DTC54PX DM3YH4I MN Alanine/serine/cysteine/threonine transporter 1 (SLC1A4) DM3YH4I MT DTP DM3YH4I MA Substrate DM3YH4I RN D-Serine Is a Substrate for Neutral Amino Acid Transporters ASCT1/SLC1A4 and ASCT2/SLC1A5, and Is Transported by Both Subtypes in Rat Hippocampal Astrocyte Cultures. PLoS One. 2016 Jun 7;11(6):e0156551. DM3YH4I RU http://www.ncbi.nlm.nih.gov/pubmed/27272177 DM3YH4I DI DM3YH4I DM3YH4I DN D-Serine DM3YH4I MI DTW7AE3 DM3YH4I MN Alanine/serine/cysteine/threonine transporter 2 (SLC1A5) DM3YH4I MT DTP DM3YH4I MA Substrate DM3YH4I RN D-Serine Is a Substrate for Neutral Amino Acid Transporters ASCT1/SLC1A4 and ASCT2/SLC1A5, and Is Transported by Both Subtypes in Rat Hippocampal Astrocyte Cultures. PLoS One. 2016 Jun 7;11(6):e0156551. DM3YH4I RU http://www.ncbi.nlm.nih.gov/pubmed/27272177 DM3YH4I DI DM3YH4I DM3YH4I DN D-Serine DM3YH4I MI DERZQ2Y DM3YH4I MN D-amino-acid oxidase (DAO) DM3YH4I MT DME DM3YH4I MA Metabolism DM3YH4I RN Focus on the role of D-serine and D-amino acid oxidase in amyotrophic lateral sclerosis/motor neuron disease (ALS). Front Mol Biosci. 2018 Feb 13;5:8. DM3YH4I RU https://www.ncbi.nlm.nih.gov/pubmed/?term=29487852 DM3YH4I DI DM3YH4I DM3YH4I DN D-Serine DM3YH4I MI TTLD29N DM3YH4I MN Glutamate receptor ionotropic NMDA 1 (NMDAR1) DM3YH4I MT DTT DM3YH4I MA Inhibitor DM3YH4I RN Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. DM3YH4I RU https://pubmed.ncbi.nlm.nih.gov/11752352 DM3YH4I DI DM3YH4I DM3YH4I DN D-Serine DM3YH4I MI DEKOQX7 DM3YH4I MN Serine racemase (SRR) DM3YH4I MT DME DM3YH4I MA Metabolism DM3YH4I RN D-Serine made by serine racemase in Drosophila intestine plays a physiological role in sleep. Nat Commun. 2019 May 7;10(1):1986. DM3YH4I RU https://www.ncbi.nlm.nih.gov/pubmed/?term=31064979 DM3YH4I DI DM3YH4I DM3YH4I DN D-Serine DM3YH4I MI TTF45NW DM3YH4I MN Strychnine-binding glycine receptor (GLRA1) DM3YH4I MT DTT DM3YH4I MA Inhibitor DM3YH4I RN Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. DM3YH4I RU https://pubmed.ncbi.nlm.nih.gov/11752352 DMQRX24 DI DMQRX24 DMQRX24 DN Ebastine DMQRX24 MI DERSX5P DMQRX24 MN Cytochrome P450 2J2 (CYP2J2) DMQRX24 MT DME DMQRX24 MA Metabolism DMQRX24 RN Identifying a selective substrate and inhibitor pair for the evaluation of CYP2J2 activity. Drug Metab Dispos. 2012 May;40(5):943-51. DMQRX24 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=22328583 DMQRX24 DI DMQRX24 DMQRX24 DN Ebastine DMQRX24 MI DE4LYSA DMQRX24 MN Cytochrome P450 3A4 (CYP3A4) DMQRX24 MT DME DMQRX24 MA Metabolism DMQRX24 RN Characterization of ebastine, hydroxyebastine, and carebastine metabolism by human liver microsomes and expressed cytochrome P450 enzymes: major roles for CYP2J2 and CYP3A. Drug Metab Dispos. 2006 Nov;34(11):1793-7. DMQRX24 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=16896065 DMQRX24 DI DMQRX24 DMQRX24 DN Ebastine DMQRX24 MI DE3GT9C DMQRX24 MN Cytochrome P450 4F2 (CYP4F2) DMQRX24 MT DME DMQRX24 MA Metabolism DMQRX24 RN cDNA cloning and expression of a novel cytochrome p450 (cyp4f12) from human small intestine. Biochem Biophys Res Commun. 2001 Feb 2;280(4):1135-41. DMQRX24 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=11162645 DMH21D9 DI DMH21D9 DMH21D9 DN Ebastine DMH21D9 MI DTUGYRD DMH21D9 MN P-glycoprotein 1 (ABCB1) DMH21D9 MT DTP DMH21D9 MA Substrate DMH21D9 RN Human intestinal transporter database: QSAR modeling and virtual profiling of drug uptake, efflux and interactions. Pharm Res. 2013 Apr;30(4):996-1007. DMH21D9 RU https://doi.org/10.1007/s11095-012-0935-x DM9WPIH DI DM9WPIH DM9WPIH DN Ergonovine maleate DM9WPIH MI DE4LYSA DM9WPIH MN Cytochrome P450 3A4 (CYP3A4) DM9WPIH MT DME DM9WPIH MA Metabolism DM9WPIH RN Rational prescription of drugs within similar therapeutic or structural class for gastrointestinal disease treatment: drug metabolism and its related interactions. World J Gastroenterol. 2007 Nov 14;13(42):5618-28. DM9WPIH RU https://www.ncbi.nlm.nih.gov/pubmed/?term=17948937 DMKEGI3 DI DMKEGI3 DMKEGI3 DN Esmirtazapine DMKEGI3 MI DECB0K3 DMKEGI3 MN Cytochrome P450 2D6 (CYP2D6) DMKEGI3 MT DME DMKEGI3 MA Metabolism DMKEGI3 RN Residual effects of esmirtazapine on actual driving performance: overall findings and an exploratory analysis into the role of CYP2D6 phenotype. Psychopharmacology (Berl). 2011 May;215(2):321-32. DMKEGI3 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=21246188 DM7ITZK DI DM7ITZK DM7ITZK DN Ethinylestradiol propanesulfonate DM7ITZK MI DE4LYSA DM7ITZK MN Cytochrome P450 3A4 (CYP3A4) DM7ITZK MT DME DM7ITZK MA Metabolism DM7ITZK RN The involvement of CYP3A4 and CYP2C9 in the metabolism of 17 alpha-ethinylestradiol. Drug Metab Dispos. 2004 Nov;32(11):1209-12. DM7ITZK RU https://www.ncbi.nlm.nih.gov/pubmed/?term=15304426 DM8TNX3 DI DM8TNX3 DM8TNX3 DN Etizolam DM8TNX3 MI DEZMWRE DM8TNX3 MN Cytochrome P450 2C18 (CYP2C18) DM8TNX3 MT DME DM8TNX3 MA Metabolism DM8TNX3 RN Etizolam (INN) Pre-Review Report. DM8TNX3 RU https://erowid.org/pharms/etizolam/etizolam_article1_who_2016.pdf DM8TNX3 DI DM8TNX3 DM8TNX3 DN Etizolam DM8TNX3 MI DE4LYSA DM8TNX3 MN Cytochrome P450 3A4 (CYP3A4) DM8TNX3 MT DME DM8TNX3 MA Metabolism DM8TNX3 RN Inhibition of the metabolism of etizolam by itraconazole in humans: evidence for the involvement of CYP3A4 in etizolam metabolism. Eur J Clin Pharmacol. 2004 Aug;60(6):427-30. DM8TNX3 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=15232663 DM8TNX3 DI DM8TNX3 DM8TNX3 DN Etizolam DM8TNX3 MI DEGTFWK DM8TNX3 MN Mephenytoin 4-hydroxylase (CYP2C19) DM8TNX3 MT DME DM8TNX3 MA Metabolism DM8TNX3 RN Effects of genetic polymorphism of cytochrome P450 enzymes on the pharmacokinetics of benzodiazepines. J Clin Pharm Ther. 2007 Aug;32(4):333-41. DM8TNX3 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=17635335 DMR7U8F DI DMR7U8F DMR7U8F DN Etoperidone DMR7U8F MI DE4LYSA DMR7U8F MN Cytochrome P450 3A4 (CYP3A4) DMR7U8F MT DME DMR7U8F MA Metabolism DMR7U8F RN In vitro identification of metabolic pathways and cytochrome P450 enzymes involved in the metabolism of etoperidone. Xenobiotica. 2002 Nov;32(11):949-62. DMR7U8F RU https://www.ncbi.nlm.nih.gov/pubmed/?term=12487725 DM9R1YU DI DM9R1YU DM9R1YU DN Gestodene DM9R1YU MI DE4LYSA DM9R1YU MN Cytochrome P450 3A4 (CYP3A4) DM9R1YU MT DME DM9R1YU MA Metabolism DM9R1YU RN Effect of an oral contraceptive preparation containing ethinylestradiol and gestodene on CYP3A4 activity as measured by midazolam 1'-hydroxylation. Br J Clin Pharmacol. 2000 Oct;50(4):333-7. DM9R1YU RU https://www.ncbi.nlm.nih.gov/pubmed/?term=11012556 DMDN4A1 DI DMDN4A1 DMDN4A1 DN Glitazone DMDN4A1 MI TTZMAO3 DMDN4A1 MN Peroxisome proliferator-activated receptor gamma (PPAR-gamma) DMDN4A1 MT DTT DMDN4A1 MA Agonist DMDN4A1 RN Peroxisome proliferator-activated receptor alpha activators improve insulin sensitivity and reduce adiposity. J Biol Chem. 2000 Jun 2;275(22):16638-42. DMDN4A1 RU https://pubmed.ncbi.nlm.nih.gov/10828060 DMF72W3 DI DMF72W3 DMF72W3 DN Glyceryl trinitrate DMF72W3 MI DEAPJSO DMF72W3 MN Microsomal glutathione S-transferase 1 (MGST1) DMF72W3 MT DME DMF72W3 MA Metabolism DMF72W3 RN Microsomal glutathione transferase 1: mechanism and functional roles. Drug Metab Rev. 2011 May;43(2):300-6. DMF72W3 RU https://pubmed.ncbi.nlm.nih.gov/21495795 DM0OX31 DI DM0OX31 DM0OX31 DN Glypromate DM0OX31 MI DEIZ2D9 DM0OX31 MN Tripeptidase (pepT) DM0OX31 MT DME DM0OX31 MA Metabolism DM0OX31 RN Tripeptidase gene (pepT) of Lactococcus lactis: molecular cloning and nucleotide sequencing of pepT and construction of a chromosomal deletion mutant. J Bacteriol. 1994 May;176(10):2854-61. DM0OX31 RU https://pubmed.ncbi.nlm.nih.gov/8188586 DM9BPLW DI DM9BPLW DM9BPLW DN Grazoprevir DM9BPLW MI DE4LYSA DM9BPLW MN Cytochrome P450 3A4 (CYP3A4) DM9BPLW MT DME DM9BPLW MA Metabolism DM9BPLW RN FDA label of Elbasvir and grazoprevir. The 2020 official website of the U.S. Food and Drug Administration. DM9BPLW RU https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/208261s002lbl.pdf DMPN5IH DI DMPN5IH DMPN5IH DN Guanfacine DMPN5IH MI DTUGYRD DMPN5IH MN P-glycoprotein 1 (ABCB1) DMPN5IH MT DTP DMPN5IH MA Substrate DMPN5IH RN An in vitro evaluation of guanfacine as a substrate for P-glycoprotein. Neuropsychiatr Dis Treat. 2011;7:501-5. DMPN5IH RU https://doi.org/10.2147/NDT.S24153 DMLYXBF DI DMLYXBF DMLYXBF DN Guanoxan DMLYXBF MI DECB0K3 DMLYXBF MN Cytochrome P450 2D6 (CYP2D6) DMLYXBF MT DME DMLYXBF MA Metabolism DMLYXBF RN Summary of information on human CYP enzymes: human P450 metabolism data. Drug Metab Rev. 2002 Feb-May;34(1-2):83-448. DMLYXBF RU https://www.ncbi.nlm.nih.gov/pubmed/?term=11996015 DM4OQRD DI DM4OQRD DM4OQRD DN HIF-1alpha DM4OQRD MI TT0LF7H DM4OQRD MN Fibroblast growth factor receptor (FGFR) DM4OQRD MT DTT DM4OQRD MA Antagonist DM4OQRD RN Tumor angiogenesis as a therapeutic target. Drug Discov Today. 2001 Oct 1;6(19):1005-1024. DM4OQRD RU https://pubmed.ncbi.nlm.nih.gov/11576867 DM4OQRD DI DM4OQRD DM4OQRD DN HIF-1alpha DM4OQRD MI TTQHWNA DM4OQRD MN Hypoxia-inducible factor 1 alpha (HIF-1A) DM4OQRD MT DTT DM4OQRD MA Inhibitor DM4OQRD RN A RNA antagonist of hypoxia-inducible factor-1alpha, EZN-2968, inhibits tumor cell growth. Mol Cancer Ther. 2008 Nov;7(11):3598-608. DM4OQRD RU https://pubmed.ncbi.nlm.nih.gov/18974394 DMYOC29 DI DMYOC29 DMYOC29 DN Hirudin DMYOC29 MI TT6L509 DMYOC29 MN Coagulation factor IIa (F2) DMYOC29 MT DTT DMYOC29 MA Inhibitor DMYOC29 RN Probing the hirudin-thrombin interaction by incorporation of noncoded amino acids and molecular dynamics simulation. Biochemistry. 2002 Nov 19;41(46):13556-69. DMYOC29 RU https://pubmed.ncbi.nlm.nih.gov/12427016 DM0WD1V DI DM0WD1V DM0WD1V DN Human calcitonin DM0WD1V MI DE7PT32 DM0WD1V MN Alanyl aminopeptidase (ANPEP) DM0WD1V MT DME DM0WD1V MA Metabolism DM0WD1V RN Renal metabolism of calcitonin. Am J Physiol. 1988 Apr;254(4 Pt 2):F593-600. DM0WD1V RU https://www.ncbi.nlm.nih.gov/pubmed/?term=2833122 DM0WD1V DI DM0WD1V DM0WD1V DN Human calcitonin DM0WD1V MI DELOWRJ DM0WD1V MN Alpha-N-acetylglucosaminidase (NAG) DM0WD1V MT DME DM0WD1V MA Metabolism DM0WD1V RN Renal metabolism of calcitonin. Am J Physiol. 1988 Apr;254(4 Pt 2):F593-600. DM0WD1V RU https://www.ncbi.nlm.nih.gov/pubmed/?term=2833122 DM0WD1V DI DM0WD1V DM0WD1V DN Human calcitonin DM0WD1V MI DEA3VM1 DM0WD1V MN Phosphoglucomutase 1 (PGM1) DM0WD1V MT DME DM0WD1V MA Metabolism DM0WD1V RN Renal metabolism of calcitonin. Am J Physiol. 1988 Apr;254(4 Pt 2):F593-600. DM0WD1V RU https://www.ncbi.nlm.nih.gov/pubmed/?term=2833122 DMABXOZ DI DMABXOZ DMABXOZ DN Hyaluronic acid DMABXOZ MI DEV7UZD DMABXOZ MN Hyaluronoglucosaminidase (nagH) DMABXOZ MT DME DMABXOZ MA Metabolism DMABXOZ RN An extracellular enzyme with hyaluronidase and chondroitinase activities from some oral anaerobic spirochaetes. Microbiology. 1996 Sep;142 ( Pt 9):2567-76. DMABXOZ RU https://pubmed.ncbi.nlm.nih.gov/8828225 DM8NWFD DI DM8NWFD DM8NWFD DN Hypericum DM8NWFD MI TTAWNKZ DM8NWFD MN Norepinephrine transporter (NET) DM8NWFD MT DTT DM8NWFD MA Inhibitor DM8NWFD RN The experimental and clinical pharmacology of St John's Wort (Hypericum perforatum L.). Mol Psychiatry. 1999 Jul;4(4):333-8. DM8NWFD RU https://pubmed.ncbi.nlm.nih.gov/10483049 DMVXLOD DI DMVXLOD DMVXLOD DN Imrecoxib DMVXLOD MI DE5IED8 DMVXLOD MN Cytochrome P450 2C9 (CYP2C9) DMVXLOD MT DME DMVXLOD MA Metabolism DMVXLOD RN Lack of effect of Imrecoxib, an innovative and moderate COX-2 inhibitor, on pharmacokinetics and pharmacodynamics of warfarin in healthy volunteers. Sci Rep. 2019 Oct 31;9(1):15774. DMVXLOD RU https://www.ncbi.nlm.nih.gov/pubmed/?term=31673051 DMVXLOD DI DMVXLOD DMVXLOD DN Imrecoxib DMVXLOD MI TT8NGED DMVXLOD MN Prostaglandin G/H synthase 1 (COX-1) DMVXLOD MT DTT DMVXLOD MA Inhibitor DMVXLOD RN Synthesis and anti-inflammatory activity of the major metabolites of imrecoxib. Bioorg Med Chem Lett. 2009 Apr 15;19(8):2270-2. DMVXLOD RU https://pubmed.ncbi.nlm.nih.gov/19286379 DMVXLOD DI DMVXLOD DMVXLOD DN Imrecoxib DMVXLOD MI TTVKILB DMVXLOD MN Prostaglandin G/H synthase 2 (COX-2) DMVXLOD MT DTT DMVXLOD MA Inhibitor DMVXLOD RN Synthesis and anti-inflammatory activity of the major metabolites of imrecoxib. Bioorg Med Chem Lett. 2009 Apr 15;19(8):2270-2. DMVXLOD RU https://pubmed.ncbi.nlm.nih.gov/19286379 DM2R496 DI DM2R496 DM2R496 DN Indenolol DM2R496 MI DECB0K3 DM2R496 MN Cytochrome P450 2D6 (CYP2D6) DM2R496 MT DME DM2R496 MA Metabolism DM2R496 RN Application of substrate depletion assay to evaluation of CYP isoforms responsible for stereoselective metabolism of carvedilol. Drug Metab Pharmacokinet. 2016 Dec;31(6):425-432. DM2R496 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=27836712 DMVPLNC DI DMVPLNC DMVPLNC DN Ingrezza DMVPLNC MI TTNZRI3 DMVPLNC MN Synaptic vesicle amine transporter (SLC18A2) DMVPLNC MT DTT DMVPLNC MA Antagonist DMVPLNC RN VMAT2 Inhibitors and the Path to Ingrezza (Valbenazine). Prog Med Chem. 2018;57(1):87-111. DMVPLNC RU https://pubmed.ncbi.nlm.nih.gov/29680151 DM7U58J DI DM7U58J DM7U58J DN Isoflavone DM7U58J MI DEUX61H DM7U58J MN Biphenyl dioxygenase (bphC) DM7U58J MT DME DM7U58J MA Metabolism DM7U58J RN Flavonoids biotransformation by bacterial non-heme dioxygenases, biphenyl and naphthalene dioxygenase. Appl Microbiol Biotechnol. 2011 Jul;91(2):219-28. DM7U58J RU https://pubmed.ncbi.nlm.nih.gov/21626021 DM7U58J DI DM7U58J DM7U58J DN Isoflavone DM7U58J MI DEE76YZ DM7U58J MN Naphthalene dioxygenase (doxB) DM7U58J MT DME DM7U58J MA Metabolism DM7U58J RN Flavonoids biotransformation by bacterial non-heme dioxygenases, biphenyl and naphthalene dioxygenase. Appl Microbiol Biotechnol. 2011 Jul;91(2):219-28. DM7U58J RU https://pubmed.ncbi.nlm.nih.gov/21626021 DM170OH DI DM170OH DM170OH DN Ketazolam DM170OH MI DE4LYSA DM170OH MN Cytochrome P450 3A4 (CYP3A4) DM170OH MT DME DM170OH MA Metabolism DM170OH RN Metabolic profile of oxazepam and related benzodiazepines: clinical and forensic aspects. Drug Metab Rev. 2017 Nov;49(4):451-463. DM170OH RU https://www.ncbi.nlm.nih.gov/pubmed/?term=28903606 DMQP5I3 DI DMQP5I3 DMQP5I3 DN Lacidipine DMQP5I3 MI DE4LYSA DMQP5I3 MN Cytochrome P450 3A4 (CYP3A4) DMQP5I3 MT DME DMQP5I3 MA Metabolism DMQP5I3 RN The effects of lacidipine on the steady/state plasma concentrations of simvastatin in healthy subjects. Br J Clin Pharmacol. 2001 Feb;51(2):147-52. DMQP5I3 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=11259986 DM5FABJ DI DM5FABJ DM5FABJ DN LAROPIPRANT DM5FABJ MI TTPADOQ DM5FABJ MN HMG-CoA reductase (HMGCR) DM5FABJ MT DTT DM5FABJ MA Inhibitor DM5FABJ RN A novel c-Met inhibitor, MK8033, synergizes with carboplatin plus paclitaxel to inhibit ovarian cancer cell growth. Oncol Rep. 2013 May;29(5):2011-8. DM5FABJ RU https://pubmed.ncbi.nlm.nih.gov/23467907 DM5FABJ DI DM5FABJ DM5FABJ DN LAROPIPRANT DM5FABJ MI TTOFYT1 DM5FABJ MN Prostacyclin receptor (PTGIR) DM5FABJ MT DTT DM5FABJ MA Inhibitor DM5FABJ RN Discovery of a potent and selective prostaglandin D2 receptor antagonist, [(3R)-4-(4-chloro-benzyl)-7-fluoro-5-(methylsulfonyl)-1,2,3,4-tetrahydroc... J Med Chem. 2007 Feb 22;50(4):794-806. DM5FABJ RU https://pubmed.ncbi.nlm.nih.gov/17300164 DM5FABJ DI DM5FABJ DM5FABJ DN LAROPIPRANT DM5FABJ MI TTNVEIR DM5FABJ MN Prostaglandin D2 receptor (PTGDR) DM5FABJ MT DTT DM5FABJ MA Inhibitor DM5FABJ RN Discovery of a potent and selective prostaglandin D2 receptor antagonist, [(3R)-4-(4-chloro-benzyl)-7-fluoro-5-(methylsulfonyl)-1,2,3,4-tetrahydroc... J Med Chem. 2007 Feb 22;50(4):794-806. DM5FABJ RU https://pubmed.ncbi.nlm.nih.gov/17300164 DM5FABJ DI DM5FABJ DM5FABJ DN LAROPIPRANT DM5FABJ MI TTQDMX5 DM5FABJ MN Prostaglandin D2 receptor 2 (PTGDR2) DM5FABJ MT DTT DM5FABJ MA Inhibitor DM5FABJ RN Discovery of a potent and selective prostaglandin D2 receptor antagonist, [(3R)-4-(4-chloro-benzyl)-7-fluoro-5-(methylsulfonyl)-1,2,3,4-tetrahydroc... J Med Chem. 2007 Feb 22;50(4):794-806. DM5FABJ RU https://pubmed.ncbi.nlm.nih.gov/17300164 DM5FABJ DI DM5FABJ DM5FABJ DN LAROPIPRANT DM5FABJ MI TT1ZAVI DM5FABJ MN Prostaglandin E2 receptor EP2 (PTGER2) DM5FABJ MT DTT DM5FABJ MA Inhibitor DM5FABJ RN Discovery of a potent and selective prostaglandin D2 receptor antagonist, [(3R)-4-(4-chloro-benzyl)-7-fluoro-5-(methylsulfonyl)-1,2,3,4-tetrahydroc... J Med Chem. 2007 Feb 22;50(4):794-806. DM5FABJ RU https://pubmed.ncbi.nlm.nih.gov/17300164 DM5FABJ DI DM5FABJ DM5FABJ DN LAROPIPRANT DM5FABJ MI TTT2ZAR DM5FABJ MN Prostaglandin F2-alpha receptor (PTGFR) DM5FABJ MT DTT DM5FABJ MA Inhibitor DM5FABJ RN Discovery of a potent and selective prostaglandin D2 receptor antagonist, [(3R)-4-(4-chloro-benzyl)-7-fluoro-5-(methylsulfonyl)-1,2,3,4-tetrahydroc... J Med Chem. 2007 Feb 22;50(4):794-806. DM5FABJ RU https://pubmed.ncbi.nlm.nih.gov/17300164 DM5FABJ DI DM5FABJ DM5FABJ DN LAROPIPRANT DM5FABJ MI TT2O84V DM5FABJ MN Thromboxane A2 receptor (TBXA2R) DM5FABJ MT DTT DM5FABJ MA Inhibitor DM5FABJ RN Discovery of a potent and selective prostaglandin D2 receptor antagonist, [(3R)-4-(4-chloro-benzyl)-7-fluoro-5-(methylsulfonyl)-1,2,3,4-tetrahydroc... J Med Chem. 2007 Feb 22;50(4):794-806. DM5FABJ RU https://pubmed.ncbi.nlm.nih.gov/17300164 DM92S6N DI DM92S6N DM92S6N DN Levamlodipine DM92S6N MI DE4LYSA DM92S6N MN Cytochrome P450 3A4 (CYP3A4) DM92S6N MT DME DM92S6N MA Metabolism DM92S6N RN Amlodipine metabolism in human liver microsomes and roles of CYP3A4/5 in the dihydropyridine dehydrogenation. Drug Metab Dispos. 2014 Feb;42(2):245-9. DM92S6N RU https://www.ncbi.nlm.nih.gov/pubmed/?term=24301608 DM92S6N DI DM92S6N DM92S6N DN Levamlodipine DM92S6N MI TTXHYV6 DM92S6N MN Voltage-gated L-type calcium channel (L-CaC) DM92S6N MT DTT DM92S6N MA Modulator DM92S6N RN Effects of (S)-amlodipine and (R)-amlodipine on L-type calcium channel current of rat ventricular myocytes and cytosolic calcium of aortic smooth muscle cells. Pharmazie. 2008 Jun;63(6):470-4. DM92S6N RU https://pubmed.ncbi.nlm.nih.gov/18604992 DM82JP0 DI DM82JP0 DM82JP0 DN Lynestrenol DM82JP0 MI DE5IED8 DM82JP0 MN Cytochrome P450 2C9 (CYP2C9) DM82JP0 MT DME DM82JP0 MA Metabolism DM82JP0 RN Identification of the human cytochrome P450 enzymes involved in the in vitro biotransformation of lynestrenol and norethindrone. J Steroid Biochem Mol Biol. 2008 May;110(1-2):56-66. DM82JP0 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=18356043 DM82JP0 DI DM82JP0 DM82JP0 DN Lynestrenol DM82JP0 MI DE4LYSA DM82JP0 MN Cytochrome P450 3A4 (CYP3A4) DM82JP0 MT DME DM82JP0 MA Metabolism DM82JP0 RN Identification of the human cytochrome P450 enzymes involved in the in vitro biotransformation of lynestrenol and norethindrone. J Steroid Biochem Mol Biol. 2008 May;110(1-2):56-66. DM82JP0 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=18356043 DM82JP0 DI DM82JP0 DM82JP0 DN Lynestrenol DM82JP0 MI DEGTFWK DM82JP0 MN Mephenytoin 4-hydroxylase (CYP2C19) DM82JP0 MT DME DM82JP0 MA Metabolism DM82JP0 RN Identification of the human cytochrome P450 enzymes involved in the in vitro biotransformation of lynestrenol and norethindrone. J Steroid Biochem Mol Biol. 2008 May;110(1-2):56-66. DM82JP0 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=18356043 DM0UGYX DI DM0UGYX DM0UGYX DN Medifoxamine DM0UGYX MI DEJVYAZ DM0UGYX MN Cytochrome P450 2A6 (CYP2A6) DM0UGYX MT DME DM0UGYX MA Metabolism DM0UGYX RN Summary of information on human CYP enzymes: human P450 metabolism data. Drug Metab Rev. 2002 Feb-May;34(1-2):83-448. DM0UGYX RU https://www.ncbi.nlm.nih.gov/pubmed/?term=11996015 DM0UGYX DI DM0UGYX DM0UGYX DN Medifoxamine DM0UGYX MI DE4LYSA DM0UGYX MN Cytochrome P450 3A4 (CYP3A4) DM0UGYX MT DME DM0UGYX MA Metabolism DM0UGYX RN Summary of information on human CYP enzymes: human P450 metabolism data. Drug Metab Rev. 2002 Feb-May;34(1-2):83-448. DM0UGYX RU https://www.ncbi.nlm.nih.gov/pubmed/?term=11996015 DME1X96 DI DME1X96 DME1X96 DN Mexazolam DME1X96 MI DE4LYSA DME1X96 MN Cytochrome P450 3A4 (CYP3A4) DME1X96 MT DME DME1X96 MA Metabolism DME1X96 RN A comparison of the effects of 3-hydroxy-3-methylglutaryl-coenzyme a (HMG-CoA) reductase inhibitors on the CYP3A4-dependent oxidation of mexazolam in vitro. Drug Metab Dispos. 2001 Mar;29(3):282-8. DME1X96 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=11181496 DM2VOQ3 DI DM2VOQ3 DM2VOQ3 DN Mosapride DM2VOQ3 MI TT07C3Y DM2VOQ3 MN 5-HT 4 receptor (HTR4) DM2VOQ3 MT DTT DM2VOQ3 MA Agonist DM2VOQ3 RN The in vitro pharmacological profile of TD-5108, a selective 5-HT(4) receptor agonist with high intrinsic activity. Naunyn Schmiedebergs Arch Pharmacol. 2008 Jul;378(1):125-37. DM2VOQ3 RU https://pubmed.ncbi.nlm.nih.gov/18415081 DM2VOQ3 DI DM2VOQ3 DM2VOQ3 DN Mosapride DM2VOQ3 MI DE4LYSA DM2VOQ3 MN Cytochrome P450 3A4 (CYP3A4) DM2VOQ3 MT DME DM2VOQ3 MA Metabolism DM2VOQ3 RN The involvement of flavin-containing monooxygenase but not CYP3A4 in metabolism of itopride hydrochloride, a gastroprokinetic agent: comparison with cisapride and mosapride citrate. Drug Metab Dispos. 2000 Oct;28(10):1231-7. DM2VOQ3 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=10997945 DMVILAD DI DMVILAD DMVILAD DN MOTILIN DMVILAD MI TT953CX DMVILAD MN Motilin receptor (MLNR) DMVILAD MT DTT DMVILAD MA Inhibitor DMVILAD RN Discovery of a new class of macrocyclic antagonists to the human motilin receptor. J Med Chem. 2006 Nov 30;49(24):7190-7. DMVILAD RU https://pubmed.ncbi.nlm.nih.gov/17125271 DMHEAB1 DI DMHEAB1 DMHEAB1 DN Neupro DMHEAB1 MI TTWFZ1N DMHEAB1 MN Dopamine receptor (DR) DMHEAB1 MT DTT DMHEAB1 MA Agonist DMHEAB1 RN Rotigotine Transdermal Patch: A Review in Parkinson's Disease. CNS Drugs. 2019 Jul;33(7):707-718. DMHEAB1 RU https://pubmed.ncbi.nlm.nih.gov/31243728 DMRP8XB DI DMRP8XB DMRP8XB DN Nomegestrol DMRP8XB MI DE4LYSA DMRP8XB MN Cytochrome P450 3A4 (CYP3A4) DMRP8XB MT DME DMRP8XB MA Metabolism DMRP8XB RN Progestogens in menopausal hormone therapy. Prz Menopauzalny. 2015 Jun;14(2):134-43. DMRP8XB RU https://www.ncbi.nlm.nih.gov/pubmed/?term=26327902 DMVAOME DI DMVAOME DMVAOME DN Oleandomycin DMVAOME MI DEYGVN4 DMVAOME MN UDP-glucuronosyltransferase 1A1 (UGT1A1) DMVAOME MT DME DMVAOME MA Metabolism DMVAOME RN Inversion of the anomeric configuration of the transferred sugar during inactivation of the macrolide antibiotic oleandomycin catalyzed by a macrolide glycosyltransferase. FEBS Lett. 2000 Jul 7;476(3):186-9. DMVAOME RU https://www.ncbi.nlm.nih.gov/pubmed/?term=10913610 DMQIMTK DI DMQIMTK DMQIMTK DN Ombitasvir DMQIMTK MI DTUGYRD DMQIMTK MN P-glycoprotein 1 (ABCB1) DMQIMTK MT DTP DMQIMTK MA Substrate DMQIMTK RN Tarascon Pocket Pharmacopoeia 2018 Classic Shirt-Pocket Edition. DMQIMTK RU https://books.google.com/books?id=0gBRDwAAQBAJ&pg=PP37&lpg=PP37&dq=Methylergonovine+transporter+uptake+efflex&source=bl&ots=cUTe_ppsmZ&sig=ACfU3U3E_YqrDg0CNEuj8K-7lci47HAnrg&hl=zh-CN&sa=X&ved=2ahUKEwjnj-Dk7d7iAhUsK6YKHd5DBDkQ6AEwEnoECAgQAQ#v=onepage&q&f=false DMPSKA5 DI DMPSKA5 DMPSKA5 DN Ortho-phosphate DMPSKA5 MI DEQ3EWA DMPSKA5 MN Maltose phosphorylase (malP) DMPSKA5 MT DME DMPSKA5 MA Metabolism DMPSKA5 RN Maltose phosphorylase from Lactobacillus brevis: purification, characterization, and application in a biosensor for ortho-phosphate. Enzyme Microb Technol. 1997 Nov 1;21(6):413-20. DMPSKA5 RU https://pubmed.ncbi.nlm.nih.gov/9343859 DMU1JVW DI DMU1JVW DMU1JVW DN Otilonium DMU1JVW MI DE4LYSA DMU1JVW MN Cytochrome P450 3A4 (CYP3A4) DMU1JVW MT DME DMU1JVW MA Metabolism DMU1JVW RN Integrated analysis on the physicochemical properties of dihydropyridine calcium channel blockers in grapefruit juice interactions. Curr Pharm Biotechnol. 2012 Jul;13(9):1705-17. DMU1JVW RU https://www.ncbi.nlm.nih.gov/pubmed/?term=22039822 DMIGKA1 DI DMIGKA1 DMIGKA1 DN Ozagrel DMIGKA1 MI TTQBR95 DMIGKA1 MN Stress-activated protein kinase 2a (p38 alpha) DMIGKA1 MT DTT DMIGKA1 MA Inhibitor DMIGKA1 RN Clinical pipeline report, company report or official report of GlaxoSmithKline (2009). DMIGKA1 RU http://www.gsk.com/investors/product_pipeline/docs/gsk-pipeline-feb09.pdf DMY2AEF DI DMY2AEF DMY2AEF DN PAI-1 DMY2AEF MI TTGY7WI DMY2AEF MN Urokinase-type plasminogen activator (PLAU) DMY2AEF MT DTT DMY2AEF MA Inhibitor DMY2AEF RN Urokinase-type plasminogen activator and its inhibitor PAI-1: predictors of poor response to tamoxifen therapy in recurrent breast cancer. J Natl Cancer Inst. 1995 May 17;87(10):751-6. DMY2AEF RU https://pubmed.ncbi.nlm.nih.gov/7563153 DMIV8CT DI DMIV8CT DMIV8CT DN Parecoxib DMIV8CT MI DE4LYSA DMIV8CT MN Cytochrome P450 3A4 (CYP3A4) DMIV8CT MT DME DMIV8CT MA Metabolism DMIV8CT RN Simultaneous determination of parecoxib and its main metabolites valdecoxib and hydroxylated valdecoxib in mouse plasma with a sensitive LC-MS/MS method to elucidate the decreased drug metabolism of tumor bearing mice. J Pharm Biomed Anal. 2018 Sep 5;158:1-7. DMIV8CT RU https://www.ncbi.nlm.nih.gov/pubmed/?term=29843006 DMIV8CT DI DMIV8CT DMIV8CT DN Parecoxib DMIV8CT MI TTSZDQU DMIV8CT MN Lactotransferrin (LTF) DMIV8CT MT DTT DMIV8CT MA Inhibitor DMIV8CT RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DMIV8CT RU https://pubmed.ncbi.nlm.nih.gov/10592235 DMQY873 DI DMQY873 DMQY873 DN Pentifylline DMQY873 MI DEJGDUW DMQY873 MN Cytochrome P450 1A2 (CYP1A2) DMQY873 MT DME DMQY873 MA Metabolism DMQY873 RN PharmGKB summary: caffeine pathway. Pharmacogenet Genomics. 2012 May;22(5):389-95. DMQY873 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=22293536 DM4OIMZ DI DM4OIMZ DM4OIMZ DN Pinaverium DM4OIMZ MI DE4LYSA DM4OIMZ MN Cytochrome P450 3A4 (CYP3A4) DM4OIMZ MT DME DM4OIMZ MA Metabolism DM4OIMZ RN Integrated analysis on the physicochemical properties of dihydropyridine calcium channel blockers in grapefruit juice interactions. Curr Pharm Biotechnol. 2012 Jul;13(9):1705-17. DM4OIMZ RU https://www.ncbi.nlm.nih.gov/pubmed/?term=22039822 DMWRYUH DI DMWRYUH DMWRYUH DN Prasterone sulfate DMWRYUH MI DERD86B DMWRYUH MN Cytochrome P450 3A7 (CYP3A7) DMWRYUH MT DME DMWRYUH MA Metabolism DMWRYUH RN CYP3A7*1C polymorphism, serum dehydroepiandrosterone sulfate level, and bone mineral density in postmenopausal women. Calcif Tissue Int. 2007 Mar;80(3):154-9. DMWRYUH RU https://www.ncbi.nlm.nih.gov/pubmed/?term=17334880 DM6VFO1 DI DM6VFO1 DM6VFO1 DN Pregnenolone DM6VFO1 MI DEN0GVQ DM6VFO1 MN Beta-HSD adrenal and gonadal type (HSD3B2) DM6VFO1 MT DME DM6VFO1 MA Metabolism DM6VFO1 RN Structure/function relationships responsible for the kinetic differences between human type 1 and type 2 3beta-hydroxysteroid dehydrogenase and for the catalysis of the type 1 activity. J Biol Chem. 2002 Nov 8;277(45):42795-801. DM6VFO1 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=12205101 DM6VFO1 DI DM6VFO1 DM6VFO1 DN Pregnenolone DM6VFO1 MI DE4LYSA DM6VFO1 MN Cytochrome P450 3A4 (CYP3A4) DM6VFO1 MT DME DM6VFO1 MA Metabolism DM6VFO1 RN Cytochrome P450 expression and regulation in CYP3A4/CYP2D6 double transgenic humanized mice. Drug Metab Dispos. 2008 Feb;36(2):435-41. DM6VFO1 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=18048490 DM6VFO1 DI DM6VFO1 DM6VFO1 DN Pregnenolone DM6VFO1 MI DERDQWN DM6VFO1 MN Dihydrotestosterone oxidoreductase (HSD3B1) DM6VFO1 MT DME DM6VFO1 MA Metabolism DM6VFO1 RN Structure/function relationships responsible for the kinetic differences between human type 1 and type 2 3beta-hydroxysteroid dehydrogenase and for the catalysis of the type 1 activity. J Biol Chem. 2002 Nov 8;277(45):42795-801. DM6VFO1 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=12205101 DM6VFO1 DI DM6VFO1 DM6VFO1 DN Pregnenolone DM6VFO1 MI TTPNQAC DM6VFO1 MN Estrogen-related receptor-alpha (ESRRA) DM6VFO1 MT DTT DM6VFO1 MA Agonist DM6VFO1 RN Suppression of adrenal function by low-dose prednisone: assessment with 24-hour urinary steroid hormone profiles--a review of five cases. Altern Med Rev. 2006 Mar;11(1):40-6. DM6VFO1 RU https://pubmed.ncbi.nlm.nih.gov/16597193 DM6VFO1 DI DM6VFO1 DM6VFO1 DN Pregnenolone DM6VFO1 MI DE0P6LK DM6VFO1 MN Sulfotransferase 2A1 (SULT2A1) DM6VFO1 MT DME DM6VFO1 MA Metabolism DM6VFO1 RN Expression and characterization of the human 3 beta-hydroxysteroid sulfotransferases (SULT2B1a and SULT2B1b). J Steroid Biochem Mol Biol. 2001 Jun;77(4-5):261-9. DM6VFO1 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=11457664 DM6VFO1 DI DM6VFO1 DM6VFO1 DN Pregnenolone DM6VFO1 MI DEZBN53 DM6VFO1 MN Sulfotransferase 2B1 (SULT2B1) DM6VFO1 MT DME DM6VFO1 MA Metabolism DM6VFO1 RN Expression and characterization of the human 3 beta-hydroxysteroid sulfotransferases (SULT2B1a and SULT2B1b). J Steroid Biochem Mol Biol. 2001 Jun;77(4-5):261-9. DM6VFO1 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=11457664 DM8PTSY DI DM8PTSY DM8PTSY DN Prenylamine DM8PTSY MI DE4LYSA DM8PTSY MN Cytochrome P450 3A4 (CYP3A4) DM8PTSY MT DME DM8PTSY MA Metabolism DM8PTSY RN Integrated analysis on the physicochemical properties of dihydropyridine calcium channel blockers in grapefruit juice interactions. Curr Pharm Biotechnol. 2012 Jul;13(9):1705-17. DM8PTSY RU https://www.ncbi.nlm.nih.gov/pubmed/?term=22039822 DM37FKA DI DM37FKA DM37FKA DN Primovist DM37FKA MI DT3D8F0 DM37FKA MN Organic anion transporting polypeptide 1B1 (SLCO1B1) DM37FKA MT DTP DM37FKA MA Substrate DM37FKA RN Organic anion transporting polypeptide 1B1: a genetically polymorphic transporter of major importance for hepatic drug uptake. Pharmacol Rev. 2011 Mar;63(1):157-81. DM37FKA RU http://www.ncbi.nlm.nih.gov/pubmed/21245207 DM37FKA DI DM37FKA DM37FKA DN Primovist DM37FKA MI DT9C1TS DM37FKA MN Organic anion transporting polypeptide 1B3 (SLCO1B3) DM37FKA MT DTP DM37FKA MA Substrate DM37FKA RN Hepatic uptake of the magnetic resonance imaging contrast agent Gd-EOB-DTPA: role of human organic anion transporters. Drug Metab Dispos. 2010 Jul;38(7):1024-8. DM37FKA RU http://www.ncbi.nlm.nih.gov/pubmed/20406852 DMXL43T DI DMXL43T DMXL43T DN Prulifloxacin DMXL43T MI DESDN74 DMXL43T MN Serum paraoxonase/arylesterase 1 (PON1) DMXL43T MT DME DMXL43T MA Metabolism DMXL43T RN Paraoxonases-1, -2 and -3: what are their functions? Chem Biol Interact. 2016 Nov 25;259(Pt B):51-62. DMXL43T RU https://www.ncbi.nlm.nih.gov/pubmed/?term=27238723 DMF8CJ9 DI DMF8CJ9 DMF8CJ9 DN Pyridine DMF8CJ9 MI TTKNWZ4 DMF8CJ9 MN Thromboxane-A synthase (TBXAS1) DMF8CJ9 MT DTT DMF8CJ9 MA Inhibitor DMF8CJ9 RN Highly selective inhibitors of thromboxane synthetase. 2. Pyridine derivatives. J Med Chem. 1981 Oct;24(10):1149-55. DMF8CJ9 RU https://pubmed.ncbi.nlm.nih.gov/7199089 DMBPN7T DI DMBPN7T DMBPN7T DN Rupatadine DMBPN7T MI DE5IED8 DMBPN7T MN Cytochrome P450 2C9 (CYP2C9) DMBPN7T MT DME DMBPN7T MA Metabolism DMBPN7T RN Product Monograph of Xtandi Rupatadine (as rupatadine fumarate). DMBPN7T RU http://www.pedia-pharm.com/en/wp-content/uploads/sites/3/2017/02/RUPALL-monograph-EN.pdf DMBPN7T DI DMBPN7T DMBPN7T DN Rupatadine DMBPN7T MI DE4LYSA DMBPN7T MN Cytochrome P450 3A4 (CYP3A4) DMBPN7T MT DME DMBPN7T MA Metabolism DMBPN7T RN Rupatadine: pharmacological profile and its use in the treatment of allergic disorders. Expert Opin Pharmacother. 2006 Oct;7(14):1989-2001. DMBPN7T RU https://www.ncbi.nlm.nih.gov/pubmed/?term=17020424 DMBPN7T DI DMBPN7T DMBPN7T DN Rupatadine DMBPN7T MI DEIBDNY DMBPN7T MN Cytochrome P450 3A5 (CYP3A5) DMBPN7T MT DME DMBPN7T MA Metabolism DMBPN7T RN CYP3A5*3 and MDR1 C3435T are influencing factors of inter-subject variability in rupatadine pharmacokinetics in healthy Chinese volunteers. Eur J Drug Metab Pharmacokinet. 2016 Apr;41(2):117-24. DMBPN7T RU https://www.ncbi.nlm.nih.gov/pubmed/?term=25427746 DMBPN7T DI DMBPN7T DMBPN7T DN Rupatadine DMBPN7T MI TTTIBOJ DMBPN7T MN Histamine H1 receptor (H1R) DMBPN7T MT DTT DMBPN7T MA Inhibitor DMBPN7T RN Designed multiple ligands. An emerging drug discovery paradigm. J Med Chem. 2005 Oct 20;48(21):6523-43. DMBPN7T RU https://pubmed.ncbi.nlm.nih.gov/16220969 DMBPN7T DI DMBPN7T DMBPN7T DN Rupatadine DMBPN7T MI TTQL5VC DMBPN7T MN Platelet-activating factor receptor (PTAFR) DMBPN7T MT DTT DMBPN7T MA Inhibitor DMBPN7T RN Designed multiple ligands. An emerging drug discovery paradigm. J Med Chem. 2005 Oct 20;48(21):6523-43. DMBPN7T RU https://pubmed.ncbi.nlm.nih.gov/16220969 DMXBYQR DI DMXBYQR DMXBYQR DN Silymarin DMXBYQR MI TT2J34L DMXBYQR MN Arachidonate 5-lipoxygenase (5-LOX) DMXBYQR MT DTT DMXBYQR MA Inhibitor DMXBYQR RN Anti-inflammatory and anti-arthritic activities of silymarin acting through inhibition of 5-lipoxygenase. Phytomedicine. 2000 Mar;7(1):21-4. DMXBYQR RU https://pubmed.ncbi.nlm.nih.gov/10782486 DMXBYQR DI DMXBYQR DMXBYQR DN Silymarin DMXBYQR MI DEYGVN4 DMXBYQR MN UDP-glucuronosyltransferase 1A1 (UGT1A1) DMXBYQR MT DME DMXBYQR MA Metabolism DMXBYQR RN Role of UDP-glucuronosyltransferase 1A1 in the metabolism and pharmacokinetics of silymarin flavonolignans in patients with HCV and NAFLD. Molecules. 2017 Jan 15;22(1). pii: E142. DMXBYQR RU https://www.ncbi.nlm.nih.gov/pubmed/?term=28098838 DMOSJD0 DI DMOSJD0 DMOSJD0 DN Sivelestat sodium hydrate DMOSJD0 MI TTPLTSQ DMOSJD0 MN Neutrophil elastase (NE) DMOSJD0 MT DTT DMOSJD0 MA Inhibitor DMOSJD0 RN Emerging therapies for treatment of acute lung injury and acute respiratory distress syndrome. Expert Opin Emerg Drugs. 2007 Sep;12(3):461-77. DMOSJD0 RU https://pubmed.ncbi.nlm.nih.gov/17874973 DMOSJD0 DI DMOSJD0 DMOSJD0 DN Sivelestat sodium hydrate DMOSJD0 MI TTEMV5X DMOSJD0 MN Serine protease unspecific (SP) DMOSJD0 MT DTT DMOSJD0 MA Inhibitor DMOSJD0 RN Emerging drugs for the treatment of chronic obstructive pulmonary disease. Expert Opin Emerg Drugs. 2006 May;11(2):275-91. DMOSJD0 RU https://pubmed.ncbi.nlm.nih.gov/16634702 DMTV7XH DI DMTV7XH DMTV7XH DN SPN-812 DMTV7XH MI TT0K1SC DMTV7XH MN 5-HT 2B receptor (HTR2B) DMTV7XH MT DTT DMTV7XH MA Antagonist DMTV7XH RN New Insights into the Mechanism of Action of Viloxazine: Serotonin and Norepinephrine Modulating Properties. J Exp Pharmacol. 2020 Aug 25;12:285-300. DMTV7XH RU https://pubmed.ncbi.nlm.nih.gov/32943948 DMTV7XH DI DMTV7XH DMTV7XH DN SPN-812 DMTV7XH MI TTAWNKZ DMTV7XH MN Norepinephrine transporter (NET) DMTV7XH MT DTT DMTV7XH MA Antagonist DMTV7XH RN New Insights into the Mechanism of Action of Viloxazine: Serotonin and Norepinephrine Modulating Properties. J Exp Pharmacol. 2020 Aug 25;12:285-300. DMTV7XH RU https://pubmed.ncbi.nlm.nih.gov/32943948 DM4TX7J DI DM4TX7J DM4TX7J DN Talipexole DM4TX7J MI TTEX248 DM4TX7J MN Dopamine D2 receptor (D2R) DM4TX7J MT DTT DM4TX7J MA Agonist DM4TX7J RN Effects of talipexole on emesis-related changes in abdominal afferent vagal activity and ileal serotonin metabolism in rats. Res Commun Mol Pathol Pharmacol. 1997 Jan;95(1):67-82. DM4TX7J RU https://pubmed.ncbi.nlm.nih.gov/9055350 DM62IPN DI DM62IPN DM62IPN DN Tenofovir disoproxil DM62IPN MI DE4LYSA DM62IPN MN Cytochrome P450 3A4 (CYP3A4) DM62IPN MT DME DM62IPN MA Metabolism DM62IPN RN FDA label of Bictegravir, emtricitabine, and tenofovir alafenamide. The 2020 official website of the U.S. Food and Drug Administration. DM62IPN RU https://www.accessdata.fda.gov/drugsatfda_docs/label/2018/210251s000lbl.pdf DMC40UY DI DMC40UY DMC40UY DN Tenofovir disoproxil DMC40UY MI DTUGYRD DMC40UY MN P-glycoprotein 1 (ABCB1) DMC40UY MT DTP DMC40UY MA Substrate DMC40UY RN Human intestinal transporter database: QSAR modeling and virtual profiling of drug uptake, efflux and interactions. Pharm Res. 2013 Apr;30(4):996-1007. DMC40UY RU https://doi.org/10.1007/s11095-012-0935-x DM2M47Y DI DM2M47Y DM2M47Y DN TKM-ApoB DM2M47Y MI TTN1IE2 DM2M47Y MN APOB messenger RNA (APOB mRNA) DM2M47Y MT DTT DM2M47Y RN Current Progress of siRNA/shRNA Therapeutics in Clinical Trials. Biotechnol J. 2011 September; 6(9): 1130-1146. DM2M47Y RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3388104/ DM7NSI0 DI DM7NSI0 DM7NSI0 DN Urethane DM7NSI0 MI DE08Z3W DM7NSI0 MN Cytosolic phospholipase A2 (PLA2G4A) DM7NSI0 MT DME DM7NSI0 MA Metabolism DM7NSI0 RN Phospholipase A2 pathway association with macrophage-mediated polycarbonate-urethane biodegradation. Biomaterials. 2005 Jun;26(18):3881-9. DM7NSI0 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=15626436 DMCOJPS DI DMCOJPS DMCOJPS DN Vonoprazan DMCOJPS MI DEPKLMQ DMCOJPS MN Cytochrome P450 2B6 (CYP2B6) DMCOJPS MT DME DMCOJPS MA Metabolism DMCOJPS RN In vitro metabolism of TAK-438, vonoprazan fumarate, a novel potassium-competitive acid blocker. Xenobiotica. 2017 Dec;47(12):1027-1034. DMCOJPS RU https://www.ncbi.nlm.nih.gov/pubmed/?term=27414183 DMCOJPS DI DMCOJPS DMCOJPS DN Vonoprazan DMCOJPS MI DECB0K3 DMCOJPS MN Cytochrome P450 2D6 (CYP2D6) DMCOJPS MT DME DMCOJPS MA Metabolism DMCOJPS RN In vitro metabolism of TAK-438, vonoprazan fumarate, a novel potassium-competitive acid blocker. Xenobiotica. 2017 Dec;47(12):1027-1034. DMCOJPS RU https://www.ncbi.nlm.nih.gov/pubmed/?term=27414183 DMCOJPS DI DMCOJPS DMCOJPS DN Vonoprazan DMCOJPS MI DE4LYSA DMCOJPS MN Cytochrome P450 3A4 (CYP3A4) DMCOJPS MT DME DMCOJPS MA Metabolism DMCOJPS RN In vitro metabolism of TAK-438, vonoprazan fumarate, a novel potassium-competitive acid blocker. Xenobiotica. 2017 Dec;47(12):1027-1034. DMCOJPS RU https://www.ncbi.nlm.nih.gov/pubmed/?term=27414183 DMCOJPS DI DMCOJPS DMCOJPS DN Vonoprazan DMCOJPS MI DEGTFWK DMCOJPS MN Mephenytoin 4-hydroxylase (CYP2C19) DMCOJPS MT DME DMCOJPS MA Metabolism DMCOJPS RN In vitro metabolism of TAK-438, vonoprazan fumarate, a novel potassium-competitive acid blocker. Xenobiotica. 2017 Dec;47(12):1027-1034. DMCOJPS RU https://www.ncbi.nlm.nih.gov/pubmed/?term=27414183 DMCOJPS DI DMCOJPS DMCOJPS DN Vonoprazan DMCOJPS MI DE0P6LK DMCOJPS MN Sulfotransferase 2A1 (SULT2A1) DMCOJPS MT DME DMCOJPS MA Metabolism DMCOJPS RN In vitro metabolism of TAK-438, vonoprazan fumarate, a novel potassium-competitive acid blocker. Xenobiotica. 2017 Dec;47(12):1027-1034. DMCOJPS RU https://www.ncbi.nlm.nih.gov/pubmed/?term=27414183 DMKV32D DI DMKV32D DMKV32D DN Xylometazoline DMKV32D MI TT2NUT5 DMKV32D MN Adrenergic receptor alpha-2C (ADRA2C) DMKV32D MT DTT DMKV32D MA Modulator DMKV32D RN Alpha-adrenoceptor agonistic activity of oxymetazoline and xylometazoline. Fundam Clin Pharmacol. 2010 Dec;24(6):729-39. DMKV32D RU https://pubmed.ncbi.nlm.nih.gov/20030735 DM9RJH7 DI DM9RJH7 DM9RJH7 DN Zaltoprofen DM9RJH7 MI DE5IED8 DM9RJH7 MN Cytochrome P450 2C9 (CYP2C9) DM9RJH7 MT DME DM9RJH7 MA Metabolism DM9RJH7 RN Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. DM9RJH7 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=19515014 DM9RJH7 DI DM9RJH7 DM9RJH7 DN Zaltoprofen DM9RJH7 MI DE073H6 DM9RJH7 MN Prostaglandin G/H synthase 1 (COX-1) DM9RJH7 MT DME DM9RJH7 MA Metabolism DM9RJH7 RN Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. DM9RJH7 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=19515014 DM9RJH7 DI DM9RJH7 DM9RJH7 DN Zaltoprofen DM9RJH7 MI DEB3CV1 DM9RJH7 MN UDP-glucuronosyltransferase 2B7 (UGT2B7) DM9RJH7 MT DME DM9RJH7 MA Metabolism DM9RJH7 RN Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. DM9RJH7 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=19515014 DMXIRA0 DI DMXIRA0 DMXIRA0 DN RLX030 DMXIRA0 MI TTMAHD1 DMXIRA0 MN Relaxin receptor 1 (RXFP1) DMXIRA0 MT DTT DMXIRA0 MA Modulator DMXIRA0 RN Design of the RELAXin in acute heart failure study. Am Heart J. 2012 Feb;163(2):149-55.e1. DMXIRA0 RU https://pubmed.ncbi.nlm.nih.gov/22305830 DMOML9Q DI DMOML9Q DMOML9Q DN Pancrecarb DMOML9Q MI TT7MRGU DMOML9Q MN Chymotrypsin (CTR) DMOML9Q MT DTT DMOML9Q MA Modulator DMOML9Q RN US patent application no. 2012,0251,516, PHARMACEUTICAL COMPOSITION FOR TREATING CANCER COMPRISING TRYPSINOGEN AND/OR CHYMOTRYPSINOGEN AND AN ACTIVE AGENT SELECTED FROM A SELENIUM COMPOUND, A VANILLOID COMPOUND AND A CYTOPLASMIC GLYCOLYSIS REDUCTION AGENT. DMOML9Q RU http://www.patentbuddy.com/Patent/20120251516?ft=true&sr=true DMOML9Q DI DMOML9Q DMOML9Q DN Pancrecarb DMOML9Q MI TTCGSZ4 DMOML9Q MN Pancreatic alpha-amylase (AMY2A) DMOML9Q MT DTT DMOML9Q MA Modulator DMOML9Q RN Clinical pipeline report, company report or official report of Digestive Care. DMOML9Q RU http://www.digestivecare.com/release102708.shtm DMOML9Q DI DMOML9Q DMOML9Q DN Pancrecarb DMOML9Q MI TTXMY0J DMOML9Q MN Pancreatic triacylglycerol lipase (PNLIP) DMOML9Q MT DTT DMOML9Q MA Modulator DMOML9Q RN Clinical pipeline report, company report or official report of Digestive Care. DMOML9Q RU http://www.digestivecare.com/release102708.shtm DMF2O4T DI DMF2O4T DMF2O4T DN (S)-FLURBIPROFEN DMF2O4T MI TT8JRS7 DMF2O4T MN Beta-secretase (BACE) DMF2O4T MT DTT DMF2O4T MA Inhibitor DMF2O4T RN The geminal dimethyl analogue of Flurbiprofen as a novel Abeta42 inhibitor and potential Alzheimer's disease modifying agent. Bioorg Med Chem Lett. 2006 Apr 15;16(8):2219-23. DMF2O4T RU https://pubmed.ncbi.nlm.nih.gov/16455248 DMF2O4T DI DMF2O4T DMF2O4T DN (S)-FLURBIPROFEN DMF2O4T MI TT9W8GU DMF2O4T MN Gamma-secretase (GS) DMF2O4T MT DTT DMF2O4T MA Inhibitor DMF2O4T RN The geminal dimethyl analogue of Flurbiprofen as a novel Abeta42 inhibitor and potential Alzheimer's disease modifying agent. Bioorg Med Chem Lett. 2006 Apr 15;16(8):2219-23. DMF2O4T RU https://pubmed.ncbi.nlm.nih.gov/16455248 DMF2O4T DI DMF2O4T DMF2O4T DN (S)-FLURBIPROFEN DMF2O4T MI TTZ3S8C DMF2O4T MN Presenilin 1 (PSEN1) DMF2O4T MT DTT DMF2O4T MA Inhibitor DMF2O4T RN The geminal dimethyl analogue of Flurbiprofen as a novel Abeta42 inhibitor and potential Alzheimer's disease modifying agent. Bioorg Med Chem Lett. 2006 Apr 15;16(8):2219-23. DMF2O4T RU https://pubmed.ncbi.nlm.nih.gov/16455248 DMF2O4T DI DMF2O4T DMF2O4T DN (S)-FLURBIPROFEN DMF2O4T MI TTWN3F4 DMF2O4T MN Presenilin 2 (PSEN2) DMF2O4T MT DTT DMF2O4T MA Inhibitor DMF2O4T RN The geminal dimethyl analogue of Flurbiprofen as a novel Abeta42 inhibitor and potential Alzheimer's disease modifying agent. Bioorg Med Chem Lett. 2006 Apr 15;16(8):2219-23. DMF2O4T RU https://pubmed.ncbi.nlm.nih.gov/16455248 DMF2O4T DI DMF2O4T DMF2O4T DN (S)-FLURBIPROFEN DMF2O4T MI TT8NGED DMF2O4T MN Prostaglandin G/H synthase 1 (COX-1) DMF2O4T MT DTT DMF2O4T MA Inhibitor DMF2O4T RN 2-Arylpropionic CXC chemokine receptor 1 (CXCR1) ligands as novel noncompetitive CXCL8 inhibitors. J Med Chem. 2005 Jun 30;48(13):4312-31. DMF2O4T RU https://pubmed.ncbi.nlm.nih.gov/15974585 DMF2O4T DI DMF2O4T DMF2O4T DN (S)-FLURBIPROFEN DMF2O4T MI TTVKILB DMF2O4T MN Prostaglandin G/H synthase 2 (COX-2) DMF2O4T MT DTT DMF2O4T MA Inhibitor DMF2O4T RN 2-Arylpropionic CXC chemokine receptor 1 (CXCR1) ligands as novel noncompetitive CXCL8 inhibitors. J Med Chem. 2005 Jun 30;48(13):4312-31. DMF2O4T RU https://pubmed.ncbi.nlm.nih.gov/15974585 DMBRFUQ DI DMBRFUQ DMBRFUQ DN B-cell lymphoma vaccine DMBRFUQ MI TT6MP2Z DMBRFUQ MN GMCSFR-alpha (CSF2RA) DMBRFUQ MT DTT DMBRFUQ RN Idiotypevaccinetherapy (BiovaxID) infollicularlymphomain first complete remission: Phase III clinical trial results, Journal of Clinical Oncology, Vol 27, No 18S (June 20 Supplement), 2009: 2. DMBRFUQ RU http://meeting.ascopubs.org/cgi/content/abstract/27/18S/2?maxtoshow=&HITS=10&hits=10&RESULTFORMAT=&fulltext=Idiotype+vaccine+therapy+(BiovaxID)+in+follicular+lymphoma+&searchid=1&FIRSTINDEX=0&volume=27&issue=18S&resourcetype=HWCIT DMP5O1U DI DMP5O1U DMP5O1U DN GSK2696273 DMP5O1U MI TTLP57V DMP5O1U MN Adenosine deaminase (ADA) DMP5O1U MT DTT DMP5O1U MA Modulator DMP5O1U RN Clinical pipeline report, company report or official report of GlaxoSmithKline. DMP5O1U RU https://www.gsk.com/en-gb/media/press-releases/2015/gsk-fondazione-telethon-and-ospedale-san-raffaele-announce-eu-regulatory-submission-for-gene-therapy-to-treat-rare-disease-ada-scid/ DMXSDJU DI DMXSDJU DMXSDJU DN MPL-containing Pollinex allergy desensitization vaccine DMXSDJU MI TTISGCA DMXSDJU MN Toll-like receptor 4 (TLR4) DMXSDJU MT DTT DMXSDJU RN Allergy Therapeutics PLC. News Announcement. Allergy Therapeutics. Clinical Trials. Allergy Therapeutics PLC. 11 October 2006. DMXSDJU RU http://miranda.hemscott.com/ir/agy/ir.jsp?page=news_regulatory&article=36483600159086 DMLRKJX DI DMLRKJX DMLRKJX DN Neugranin DMLRKJX MI TT5TQ2W DMLRKJX MN Granulocyte colony-stimulating factor (CSF3) DMLRKJX MT DTT DMLRKJX MA Modulator DMLRKJX RN Development and Characterization of a Novel Fusion Protein of a Mutated Granulocyte Colony-Stimulating Factor and Human Serum Albumin in Pichia pastoris. PLoS One. 2014; 9(12): e115840. DMLRKJX RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4275271/ DMUY09W DI DMUY09W DMUY09W DN SK-NBP601 DMUY09W MI TT1290U DMUY09W MN Coagulation factor VIII (F8) DMUY09W MT DTT DMUY09W MA Inhibitor DMUY09W RN Clinical pipeline report, company report or official report of SK Chemicals. DMUY09W RU http://www.skchemicals.com/en/about/rd_result.asp DM26I8H DI DM26I8H DM26I8H DN TK-DLI DM26I8H MI TTP3QRF DM26I8H MN Thymidine kinase 1 (TK1) DM26I8H MT DTT DM26I8H MA Modulator DM26I8H RN Company report (Takara Bio) DM26I8H RU http://www.takara-bio.com/news_e/2008/10/07.htm DMYA6TR DI DMYA6TR DMYA6TR DN Human coagulation factor X DMYA6TR MI TTCIHJA DMYA6TR MN Coagulation factor Xa (F10) DMYA6TR MT DTT DMYA6TR MA Modulator DMYA6TR RN Semuloparin for the prevention of venous thromboembolic events in cancer patients. Drugs Today (Barc). 2012 Jul;48(7):451-7. DMYA6TR RU https://pubmed.ncbi.nlm.nih.gov/22844656 DMNCY1I DI DMNCY1I DMNCY1I DN (-)-Phenserine DMNCY1I MI TT1RS9F DMNCY1I MN Acetylcholinesterase (AChE) DMNCY1I MT DTT DMNCY1I MA Inhibitor DMNCY1I RN Long-acting anticholinesterases for myasthenia gravis: synthesis and activities of quaternary phenylcarbamates of neostigmine, pyridostigmine and physostigmine. Bioorg Med Chem. 2010 Jul 1;18(13):4687-93. DMNCY1I RU https://pubmed.ncbi.nlm.nih.gov/20627738 DMNCY1I DI DMNCY1I DMNCY1I DN (-)-Phenserine DMNCY1I MI TTEB0GD DMNCY1I MN Cholinesterase (BCHE) DMNCY1I MT DTT DMNCY1I MA Inhibitor DMNCY1I RN Long-acting anticholinesterases for myasthenia gravis: synthesis and activities of quaternary phenylcarbamates of neostigmine, pyridostigmine and physostigmine. Bioorg Med Chem. 2010 Jul 1;18(13):4687-93. DMNCY1I RU https://pubmed.ncbi.nlm.nih.gov/20627738 DMLRHM5 DI DMLRHM5 DMLRHM5 DN [3H](R)-(-)-baclofen DMLRHM5 MI TTDCVZW DMLRHM5 MN Gamma-aminobutyric acid B receptor (GABBR) DMLRHM5 MT DTT DMLRHM5 MA Agonist DMLRHM5 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 242). DMLRHM5 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=242 DM3YEV0 DI DM3YEV0 DM3YEV0 DN 131I-labelled aCD45 DM3YEV0 MI TTUS45N DM3YEV0 MN Leukocyte common antigen (PTPRC) DM3YEV0 MT DTT DM3YEV0 RN 131I-anti-CD45 antibody plus busulfan and cyclophosphamide before allogeneic hematopoietic cell transplantation for treatment of acute myeloid leukemia in first remission. Blood. 2006 Mar 1;107(5):2184-91. DM3YEV0 RU https://pubmed.ncbi.nlm.nih.gov/16254140 DMTZ1A5 DI DMTZ1A5 DMTZ1A5 DN 13-cis-retinoic acid DMTZ1A5 MI TTOD7B3 DMTZ1A5 MN Retinoic acid receptor (RAR) DMTZ1A5 MT DTT DMTZ1A5 MA Modulator DMTZ1A5 RN 13-cis retinoic acid exerts its specific activity on human sebocytes through selective intracellular isomerization to all-trans retinoic acid and binding to retinoid acid receptors. J Invest Dermatol. 2000 Aug;115(2):321-7. DMTZ1A5 RU https://pubmed.ncbi.nlm.nih.gov/10951254 DMP5L8S DI DMP5L8S DMP5L8S DN 177Lu-DOTA-octreotate DMP5L8S MI TTOMNR9 DMP5L8S MN Somatostatin receptor (SSTR) DMP5L8S MT DTT DMP5L8S MA Modulator DMP5L8S RN Peptide receptor radionuclide therapy with 177Lu-DOTATATE for patients with somatostatin receptor-expressing neuroendocrine tumors: the first US phase 2 experience. Pancreas. 2014 May;43(4):518-25. DMP5L8S RU https://pubmed.ncbi.nlm.nih.gov/24632546 DMQ0IZ6 DI DMQ0IZ6 DMQ0IZ6 DN 177Lu-labelled PSMA-617 DMQ0IZ6 MI TT9G4N0 DMQ0IZ6 MN Glutamate carboxypeptidase II (GCPII) DMQ0IZ6 MT DTT DMQ0IZ6 RN [177Lu-PSMA-617 therapy, dosimetry and follow-up in patients with metastatic castration-resistant prostate cancer]. Nuklearmedizin. 2016 Jun 28;55(3):123-8. DMQ0IZ6 RU https://pubmed.ncbi.nlm.nih.gov/27350005 DMMZS2T DI DMMZS2T DMMZS2T DN 177-Lu-oxodotreotide DMMZS2T MI TTOMNR9 DMMZS2T MN Somatostatin receptor (SSTR) DMMZS2T MT DTT DMMZS2T MA Agonist DMMZS2T RN Lutetium-labelled peptides for therapy of neuroendocrine tumours. Eur J Nucl Med Mol Imaging. 2012 Feb;39 Suppl 1(Suppl 1):S103-12. DMMZS2T RU https://pubmed.ncbi.nlm.nih.gov/22388631 DMX178V DI DMX178V DMX178V DN 177-Lu-PSMA-617 DMX178V MI TT9G4N0 DMX178V MN Glutamate carboxypeptidase II (GCPII) DMX178V MT DTT DMX178V MA Agonist DMX178V RN Review of 177Lu-PSMA-617 in Patients With Metastatic Castration-Resistant Prostate Cancer. Cureus. 2020 Jun 30;12(6):e8921. DMX178V RU https://pubmed.ncbi.nlm.nih.gov/32760622 DME2A8X DI DME2A8X DME2A8X DN 5-methoxypsoralen DME2A8X MI DE6OQ3W DME2A8X MN Cytochrome P450 1A1 (CYP1A1) DME2A8X MT DME DME2A8X MA Metabolism DME2A8X RN Cytochrome P450 CYP1B1 interacts with 8-methoxypsoralen (8-MOP) and influences psoralen-ultraviolet A (PUVA) sensitivity. PLoS One. 2013 Sep 23;8(9):e75494. DME2A8X RU https://www.ncbi.nlm.nih.gov/pubmed/?term=24086543 DME2A8X DI DME2A8X DME2A8X DN 5-methoxypsoralen DME2A8X MI DEJGDUW DME2A8X MN Cytochrome P450 1A2 (CYP1A2) DME2A8X MT DME DME2A8X MA Metabolism DME2A8X RN Cytochrome P450 CYP1B1 interacts with 8-methoxypsoralen (8-MOP) and influences psoralen-ultraviolet A (PUVA) sensitivity. PLoS One. 2013 Sep 23;8(9):e75494. DME2A8X RU https://www.ncbi.nlm.nih.gov/pubmed/?term=24086543 DME2A8X DI DME2A8X DME2A8X DN 5-methoxypsoralen DME2A8X MI DE9QHP6 DME2A8X MN Cytochrome P450 1B1 (CYP1B1) DME2A8X MT DME DME2A8X MA Metabolism DME2A8X RN Cytochrome P450 CYP1B1 interacts with 8-methoxypsoralen (8-MOP) and influences psoralen-ultraviolet A (PUVA) sensitivity. PLoS One. 2013 Sep 23;8(9):e75494. DME2A8X RU https://www.ncbi.nlm.nih.gov/pubmed/?term=24086543 DME2A8X DI DME2A8X DME2A8X DN 5-methoxypsoralen DME2A8X MI DEJVYAZ DME2A8X MN Cytochrome P450 2A6 (CYP2A6) DME2A8X MT DME DME2A8X MA Metabolism DME2A8X RN Cytochrome P450 CYP1B1 interacts with 8-methoxypsoralen (8-MOP) and influences psoralen-ultraviolet A (PUVA) sensitivity. PLoS One. 2013 Sep 23;8(9):e75494. DME2A8X RU https://www.ncbi.nlm.nih.gov/pubmed/?term=24086543 DME2A8X DI DME2A8X DME2A8X DN 5-methoxypsoralen DME2A8X MI DEVDYN7 DME2A8X MN Cytochrome P450 2E1 (CYP2E1) DME2A8X MT DME DME2A8X MA Metabolism DME2A8X RN Cytochrome P450 CYP1B1 interacts with 8-methoxypsoralen (8-MOP) and influences psoralen-ultraviolet A (PUVA) sensitivity. PLoS One. 2013 Sep 23;8(9):e75494. DME2A8X RU https://www.ncbi.nlm.nih.gov/pubmed/?term=24086543 DME2A8X DI DME2A8X DME2A8X DN 5-methoxypsoralen DME2A8X MI DE4LYSA DME2A8X MN Cytochrome P450 3A4 (CYP3A4) DME2A8X MT DME DME2A8X MA Metabolism DME2A8X RN Metabolism of 5-methoxypsoralen by Saccharomyces cerevisiae. Photochem Photobiol. 1991 Nov;54(5):689-95. DME2A8X RU https://www.ncbi.nlm.nih.gov/pubmed/?term=1798745 DM4OHMP DI DM4OHMP DM4OHMP DN A-3309 DM4OHMP MI TTPI1M5 DM4OHMP MN Ileal sodium/bile acid cotransporter (SLC10A2) DM4OHMP MT DTT DM4OHMP MA Inhibitor DM4OHMP RN Elobixibat for the treatment of constipation. Expert Opin Investig Drugs. 2013 Feb;22(2):277-84. DM4OHMP RU https://pubmed.ncbi.nlm.nih.gov/23215781 DMJNSLU DI DMJNSLU DMJNSLU DN AAV2-hRPE65v2 DMJNSLU MI TTBOH16 DMJNSLU MN Retinal pigment epithelium protein (RPE65) DMJNSLU MT DTT DMJNSLU MA Modulator DMJNSLU RN AAV2 gene therapy readministration in three adults with congenital blindness. Sci Transl Med. 2012 Feb 8;4(120):120ra15. DMJNSLU RU https://pubmed.ncbi.nlm.nih.gov/22323828 DMPDQ8T DI DMPDQ8T DMPDQ8T DN AB-103 DMPDQ8T MI TTQ13FT DMPDQ8T MN T-cell-specific surface glycoprotein CD28 (CD28) DMPDQ8T MT DTT DMPDQ8T MA Antagonist DMPDQ8T RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMPDQ8T RU http://phrma-docs.phrma.org/files/dmfile/MID_Skin_Diseases_2018_9_FINAL.pdf DMUES7Y DI DMUES7Y DMUES7Y DN AB154 DMUES7Y MI TTWNL74 DMUES7Y MN V-set and immunoglobulin domain-containing protein 9 (TIGIT) DMUES7Y MT DTT DMUES7Y MA Inhibitor DMUES7Y RN Clinical pipeline report, company report or official report of Arcus Biosciences. DMUES7Y RU https://arcusbio.com/domvanalimab/ DMMWO7V DI DMMWO7V DMMWO7V DN ABBV-951 DMMWO7V MI TTWFZ1N DMMWO7V MN Dopamine receptor (DR) DMMWO7V MT DTT DMMWO7V MA Activator DMMWO7V RN Foslevodopa/Foscarbidopa: A New Subcutaneous Treatment for Parkinson's Disease. Ann Neurol. 2021 Jul;90(1):52-61. DMMWO7V RU https://pubmed.ncbi.nlm.nih.gov/33772855 DMCKPG4 DI DMCKPG4 DMCKPG4 DN ABC294640 DMCKPG4 MI TTCN0M9 DMCKPG4 MN Sphingosine kinase 2 (SPHK2) DMCKPG4 MT DTT DMCKPG4 MA Modulator DMCKPG4 RN Targeting the sphingosine-1-phosphate axis in cancer, inflammation and beyond. Nat Rev Drug Discov. 2013 Sep;12(9):688-702. DMCKPG4 RU https://pubmed.ncbi.nlm.nih.gov/23954895 DM91LGU DI DM91LGU DM91LGU DN Abexinostat DM91LGU MI TTBH0VX DM91LGU MN Histone deacetylase (HDAC) DM91LGU MT DTT DM91LGU MA Modulator DM91LGU RN Phase 1 study of the oral histone deacetylase inhibitor abexinostat in patients with Hodgkin lymphoma, non-Hodgkin lymphoma, or chronic lymphocytic leukaemia. Invest New Drugs. 2015 Apr;33(2):423-31. DM91LGU RU https://pubmed.ncbi.nlm.nih.gov/25600050 DMMF5K4 DI DMMF5K4 DMMF5K4 DN ABL 001 DMMF5K4 MI TTS7G69 DMMF5K4 MN Fusion protein Bcr-Abl (Bcr-Abl) DMMF5K4 MT DTT DMMF5K4 MA Inhibitor DMMF5K4 RN ABL001, a Potent Allosteric Inhibitor of BCR-ABL, Prevents Emergence of Resistant Disease When Administered in Combination with Nilotinib in an in Vivo Murine Model of Chronic Myeloid Leukemia, NorthBuilding, 2014, 120-125. DMMF5K4 RU https://ash.confex.com/ash/2014/webprogram/Paper76344.html DM7EVUF DI DM7EVUF DM7EVUF DN ABL001 DM7EVUF MI TTS7G69 DM7EVUF MN Fusion protein Bcr-Abl (Bcr-Abl) DM7EVUF MT DTT DM7EVUF MA Inhibitor DM7EVUF RN Asciminib in Chronic Myeloid Leukemia after ABL Kinase Inhibitor Failure. N Engl J Med. 2019 Dec 12;381(24):2315-2326. DM7EVUF RU https://pubmed.ncbi.nlm.nih.gov/31826340 DM2J4YB DI DM2J4YB DM2J4YB DN ABP 501 DM2J4YB MI TTF8CQI DM2J4YB MN Tumor necrosis factor (TNF) DM2J4YB MT DTT DM2J4YB RN Case study: biosimilar anti TNFalpha (Adalimumab) analysis of Fc effector functions. BMC Proc. 2013; 7(Suppl 6): P30. DM2J4YB RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3980296/ DMDXE4I DI DMDXE4I DMDXE4I DN ABP959 DMDXE4I MI TTKANGO DMDXE4I MN Complement C5 (CO5) DMDXE4I MT DTT DMDXE4I MA Inhibitor DMDXE4I RN A randomized, double-blind, single-dose, three-arm, parallel group study to determine pharmacokinetic similarity of ABP 959 and eculizumab (Soliris ?) in healthy male subjects. Eur J Haematol. 2020 Jul;105(1):66-74. DMDXE4I RU https://pubmed.ncbi.nlm.nih.gov/32196749 DMNE56X DI DMNE56X DMNE56X DN ABT-263 DMNE56X MI TTJGNVC DMNE56X MN Apoptosis regulator Bcl-2 (BCL-2) DMNE56X MT DTT DMNE56X MA Inhibitor DMNE56X RN Clinical pipeline report, company report or official report of Roche (2009). DMNE56X RU http://www.roche.com/research_and_development/pipeline/roche_pharma_pipeline.htm DMNE56X DI DMNE56X DMNE56X DN ABT-263 DMNE56X MI TTQ79W8 DMNE56X MN Apoptosis regulator Bcl-W (BCL-W) DMNE56X MT DTT DMNE56X MA Inhibitor DMNE56X RN Clinical pipeline report, company report or official report of Roche (2009). DMNE56X RU http://www.roche.com/research_and_development/pipeline/roche_pharma_pipeline.htm DMNE56X DI DMNE56X DMNE56X DN ABT-263 DMNE56X MI TTU1E82 DMNE56X MN Apoptosis regulator Bcl-xL (BCL-xL) DMNE56X MT DTT DMNE56X MA Inhibitor DMNE56X RN Clinical pipeline report, company report or official report of Roche (2009). DMNE56X RU http://www.roche.com/research_and_development/pipeline/roche_pharma_pipeline.htm DMNE56X DI DMNE56X DMNE56X DN ABT-263 DMNE56X MI DE4LYSA DMNE56X MN Cytochrome P450 3A4 (CYP3A4) DMNE56X MT DME DMNE56X MA Metabolism DMNE56X RN Effect of rifampin on the pharmacokinetics, safety and tolerability of navitoclax (ABT-263), a dual inhibitor of Bcl-2 and Bcl-XL , in patients with cancer. J Clin Pharm Ther. 2014 Dec;39(6):680-4. DMNE56X RU https://www.ncbi.nlm.nih.gov/pubmed/?term=25047139 DMNE56X DI DMNE56X DMNE56X DN ABT-263 DMNE56X MI TTFCJ7S DMNE56X MN G1/S-specific cyclin-D1 (CCND1) DMNE56X MT DTT DMNE56X MA Inhibitor DMNE56X RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMNE56X RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DMNE56X DI DMNE56X DMNE56X DN ABT-263 DMNE56X MI DTUGYRD DMNE56X MN P-glycoprotein 1 (ABCB1) DMNE56X MT DTP DMNE56X MA Substrate DMNE56X RN The B-cell lymphoma 2 (BCL2)-inhibitors, ABT-737 and ABT-263, are substrates for P-glycoprotein. Biochem Biophys Res Commun. 2011 May 6;408(2):344-9. DMNE56X RU https://doi.org/10.1016/j.bbrc.2011.04.043 DMNQ869 DI DMNQ869 DMNQ869 DN ABT-267 DMNQ869 MI DES5XRU DMNQ869 MN Cytochrome P450 2C8 (CYP2C8) DMNQ869 MT DME DMNQ869 MA Metabolism DMNQ869 RN Metabolism and disposition of pan-genotypic inhibitor of hepatitis C virus NS5A ombitasvir in humans. Drug Metab Dispos. 2016 Aug;44(8):1148-57. DMNQ869 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=27179128 DMNQ869 DI DMNQ869 DMNQ869 DN ABT-267 DMNQ869 MI TTCJ2X8 DMNQ869 MN Hepatitis C virus Non-structural 5A (HCV NS5A) DMNQ869 MT DTT DMNQ869 MA Modulator DMNQ869 RN Discovery of ABT-267, a pan-genotypic inhibitor of HCV NS5A. J Med Chem. 2014 Mar 13;57(5):2047-57. DMNQ869 RU https://pubmed.ncbi.nlm.nih.gov/24400777 DMJFD2I DI DMJFD2I DMJFD2I DN ABT-492 DMJFD2I MI TTIXTO3 DMJFD2I MN Staphylococcus Topoisomerase IV (Stap-coc parC) DMJFD2I MT DTT DMJFD2I MA Modulator DMJFD2I RN Contrasting Effects of Acidic pH on the Extracellular and Intracellular Activities of the Anti-Gram-Positive Fluoroquinolones Moxifloxacin and Delafloxacin against Staphylococcus aureus DMJFD2I RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3028753 DMJFD2I DI DMJFD2I DMJFD2I DN ABT-492 DMJFD2I MI DEYGVN4 DMJFD2I MN UDP-glucuronosyltransferase 1A1 (UGT1A1) DMJFD2I MT DME DMJFD2I MA Metabolism DMJFD2I RN Delafloxacin: place in therapy and review of microbiologic, clinical and pharmacologic properties. Infect Dis Ther. 2018 Jun;7(2):197-217. DMJFD2I RU https://www.ncbi.nlm.nih.gov/pubmed/?term=29605887 DM3FIC2 DI DM3FIC2 DM3FIC2 DN ABT-761 DM3FIC2 MI TT2J34L DM3FIC2 MN Arachidonate 5-lipoxygenase (5-LOX) DM3FIC2 MT DTT DM3FIC2 MA Inhibitor DM3FIC2 RN Treatment with 5-lipoxygenase inhibitor VIA-2291 (Atreleuton) in patients with recent acute coronary syndrome. Circ Cardiovasc Imaging. 2010 May;3(3):298-307. DM3FIC2 RU https://pubmed.ncbi.nlm.nih.gov/20190281 DM3FIC2 DI DM3FIC2 DM3FIC2 DN ABT-761 DM3FIC2 MI DE4LYSA DM3FIC2 MN Cytochrome P450 3A4 (CYP3A4) DM3FIC2 MT DME DM3FIC2 MA Metabolism DM3FIC2 RN Identification of the human liver cytochrome P450 enzymes involved in the in vitro metabolism of a novel 5-lipoxygenase inhibitor. Drug Metab Dispos. 1998 Oct;26(10):970-6. DM3FIC2 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=9763401 DMREDYP DI DMREDYP DMREDYP DN ABT-869 DMREDYP MI TTDCBX5 DMREDYP MN Vascular endothelial growth factor receptor 3 (FLT-4) DMREDYP MT DTT DMREDYP MA Modulator DMREDYP RN Preclinical activity of ABT-869, a multitargeted receptor tyrosine kinase inhibitor. Mol Cancer Ther. 2006 Apr;5(4):995-1006. DMREDYP RU https://pubmed.ncbi.nlm.nih.gov/16648571 DMYHSO2 DI DMYHSO2 DMYHSO2 DN ABT-874 DMYHSO2 MI TTGW72V DMYHSO2 MN Interleukin-12 beta (IL12B) DMYHSO2 MT DTT DMYHSO2 MA Modulator DMYHSO2 RN Briakinumab for the treatment of plaque psoriasis.BioDrugs.2012 Feb 1;26(1):9-20. DMYHSO2 RU https://www.ncbi.nlm.nih.gov/pubmed/22077474 DM4HYMS DI DM4HYMS DM4HYMS DN ABT-888 DM4HYMS MI TTEBCY8 DM4HYMS MN Poly [ADP-ribose] polymerase (PARP) DM4HYMS MT DTT DM4HYMS MA Modulator DM4HYMS RN Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41. DM4HYMS RU https://www.ncbi.nlm.nih.gov/pubmed/15950434 DMQRL2Y DI DMQRL2Y DMQRL2Y DN AC0010 DMQRL2Y MI TTG96HZ DMQRL2Y MN EGFR messenger RNA (EGFR mRNA) DMQRL2Y MT DTT DMQRL2Y MA Inhibitor DMQRL2Y RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMQRL2Y RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DMXZ9T3 DI DMXZ9T3 DMXZ9T3 DN AC-170 DMXZ9T3 MI TTTIBOJ DMXZ9T3 MN Histamine H1 receptor (H1R) DMXZ9T3 MT DTT DMXZ9T3 MA Antagonist DMXZ9T3 RN Clinical pipeline report, company report or official report of NicOx SA. DMXZ9T3 RU http://www.nicox.com/rd/ac-170/ DM8Y4JS DI DM8Y4JS DM8Y4JS DN AC220 DM8Y4JS MI TTGJCWZ DM8Y4JS MN Fms-like tyrosine kinase 3 (FLT-3) DM8Y4JS MT DTT DM8Y4JS MA Inhibitor DM8Y4JS RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DM8Y4JS RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DM1RMF5 DI DM1RMF5 DM1RMF5 DN Acadesine DM1RMF5 MI TTLAFZV DM1RMF5 MN AMP-activated protein kinase (AMPK) DM1RMF5 MT DTT DM1RMF5 MA Modulator DM1RMF5 RN Acadesine, an adenosine-regulating agent with the potential for widespread indications. Expert Opin Pharmacother. 2008 Aug;9(12):2137-44. DM1RMF5 RU https://pubmed.ncbi.nlm.nih.gov/18671468 DMY96O3 DI DMY96O3 DMY96O3 DN acelarin DMY96O3 MI TTUBNVO DMY96O3 MN DNA synthesis (DNA synth) DMY96O3 MT DTT DMY96O3 MA Inhibitor DMY96O3 RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMY96O3 RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DM3UQ9K DI DM3UQ9K DM3UQ9K DN Acolbifene DM3UQ9K MI TTZAYWL DM3UQ9K MN Estrogen receptor (ESR) DM3UQ9K MT DTT DM3UQ9K MA Modulator DM3UQ9K RN Bioactivation of the selective estrogen receptor modulator acolbifene to quinone methides. Chem Res Toxicol. 2005 Feb;18(2):174-82. DM3UQ9K RU https://pubmed.ncbi.nlm.nih.gov/15720121 DMXYRPO DI DMXYRPO DMXYRPO DN Act1 DMXYRPO MI TT4F7SL DMXYRPO MN Gap junction alpha-1 protein (GJA1) DMXYRPO MT DTT DMXYRPO MA Modulator DMXYRPO RN Company report (FirstString Research) DMXYRPO RU http://firststringresearch.com/platform-technology/ DMVLWG7 DI DMVLWG7 DMVLWG7 DN Ad5FGF-4 DMVLWG7 MI TTCEKVZ DMVLWG7 MN Fibroblast growth factor-4 (FGF4) DMVLWG7 MT DTT DMVLWG7 MA Modulator DMVLWG7 RN Angiogenic gene therapy with adenovirus 5 fibroblast growth factor-4 (Ad5FGF-4): a new option for the treatment of coronary artery disease. Am J Cardiol. 2003 Nov 7;92(9B):24N-31N. DMVLWG7 RU https://pubmed.ncbi.nlm.nih.gov/14615023 DMFIP35 DI DMFIP35 DMFIP35 DN Adhexil DMFIP35 MI TTWODQF DMFIP35 MN Fibrin (FG) DMFIP35 MT DTT DMFIP35 MA Modulator DMFIP35 RN Evaluation of a fibrin preparation containing tranexamic acid (Adhexil) in a rabbit uterine horn model of adhesions with and without bleeding and in a model with two surgical loci. Fertil Steril. 2010 Mar 1;93(4):1045-51. DMFIP35 RU https://pubmed.ncbi.nlm.nih.gov/19147133 DMLBYRA DI DMLBYRA DMLBYRA DN ADX N05 DMLBYRA MI TT5TPI6 DMLBYRA MN Opioid receptor sigma 1 (OPRS1) DMLBYRA MT DTT DMLBYRA MA Modulator DMLBYRA RN Clinical pipeline report, company report or official report of SK BioPhamaceuticals. DMLBYRA RU http://www.skbp.com/etc/news_view_14.asp DMAYO46 DI DMAYO46 DMAYO46 DN AEZS-108 DMAYO46 MI TT8R70G DMAYO46 MN Gonadotropin-releasing hormone receptor (GNRHR) DMAYO46 MT DTT DMAYO46 MA Modulator DMAYO46 RN Stability of cytotoxic luteinizing hormone-releasing hormone conjugate (AN-152) containing doxorubicin 14-O-hemiglutarate in mouse and human serum in vitro: implications for the design of preclinicalstudies. Proc Natl Acad Sci U S A. 2000 Jan 18;97(2):829-34. DMAYO46 RU https://pubmed.ncbi.nlm.nih.gov/10639165 DMS0ZBI DI DMS0ZBI DMS0ZBI DN Ag-221 DMS0ZBI MI TTDTWV0 DMS0ZBI MN Isocitrate dehydrogenase (IDH) DMS0ZBI MT DTT DMS0ZBI MA Inhibitor DMS0ZBI RN New Developments in the Pathogenesis and Therapeutic Targeting of the IDH1 Mutation in Glioma. Int J Med Sci. 2015; 12(3): 201-213. DMS0ZBI RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4323358/ DMIE1WY DI DMIE1WY DMIE1WY DN AG-881 DMIE1WY MI TTDTWV0 DMIE1WY MN Isocitrate dehydrogenase (IDH) DMIE1WY MT DTT DMIE1WY MA Inhibitor DMIE1WY RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMIE1WY RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DMYN3IH DI DMYN3IH DMYN3IH DN AGI-1067 DMYN3IH MI TT1AVS7 DMYN3IH MN Second phase insulin secretion (SPI secr) DMYN3IH MT DTT DMYN3IH MA Inhibitor DMYN3IH RN AGI-1067, a novel antioxidant and anti-inflammatory agent, enhances insulin release and protects mouse islets. Mol Cell Endocrinol. 2010 Jul 29;323(2):246-55. DMYN3IH RU https://pubmed.ncbi.nlm.nih.gov/20211684 DMJRQDG DI DMJRQDG DMJRQDG DN AG-SPT201 DMJRQDG MI TTF1QVM DMJRQDG MN Gastric H(+)/K(+) ATPase alpha (ATP4A) DMJRQDG MT DTT DMJRQDG MA Modulator DMJRQDG RN Effects of pantoprazole, a novel H+/K+-ATPase inhibitor, on duodenal ulcerogenic and healing responses in rats: a comparative study with omeprazole and lansoprazole. J Gastroenterol Hepatol. 1999 Mar;14(3):251-7. DMJRQDG RU https://pubmed.ncbi.nlm.nih.gov/10197495 DMS2WV3 DI DMS2WV3 DMS2WV3 DN AIDSVAX DMS2WV3 MI TTBYP1X DMS2WV3 MN Human immunodeficiency virus Envelope glycoprotein gp120 (HIV gp120) DMS2WV3 MT DTT DMS2WV3 RN HIV gp120 vaccine - VaxGen: AIDSVAX, AIDSVAX B/B, AIDSVAX B/E, HIV gp120 vaccine - Genentech, HIV gp120 vaccine AIDSVAX - VaxGen, HIV vaccine AIDSVAX - VaxGen. Drugs R D. 2003;4(4):249-53. DMS2WV3 RU https://pubmed.ncbi.nlm.nih.gov/12848591 DM8SYTE DI DM8SYTE DM8SYTE DN AIR-insulin DM8SYTE MI TTF89GD DM8SYTE MN Interleukin-2 (IL2) DM8SYTE MT DTT DM8SYTE MA Modulator DM8SYTE RN The AIR inhaled insulin system: system components and pharmacokinetic/glucodynamic data. Diabetes Technol Ther. 2007 Jun;9 Suppl 1:S41-7. DM8SYTE RU https://pubmed.ncbi.nlm.nih.gov/17563303 DM5K6J4 DI DM5K6J4 DM5K6J4 DN AJM-300 DM5K6J4 MI TT6S84X DM5K6J4 MN Integrin alpha-4/beta-1 (ITGA4/B1) DM5K6J4 MT DTT DM5K6J4 MA Modulator DM5K6J4 RN Oral treatment with a novel small molecule alpha 4 integrin antagonist, AJM300, prevents the development of experimental colitis in mice. J Crohns Colitis. 2013 Dec;7(11):e533-42. DM5K6J4 RU https://pubmed.ncbi.nlm.nih.gov/23623333 DM2EJM3 DI DM2EJM3 DM2EJM3 DN AKB-6548 DM2EJM3 MI TTJQFBG DM2EJM3 MN HIF-prolyl hydroxylase (HPH) DM2EJM3 MT DTT DM2EJM3 MA Modulator DM2EJM3 RN DOI: 10.1038/nrd4422 DM2EJM3 RU http://www.nature.com/nrd/journal/v13/n11/fig_tab/nrd4422_T2.html DM3WP0N DI DM3WP0N DM3WP0N DN Al3818 DM3WP0N MI DE4LYSA DM3WP0N MN Cytochrome P450 3A4 (CYP3A4) DM3WP0N MT DME DM3WP0N MA Metabolism DM3WP0N RN Anlotinib: a novel multi-targeting tyrosine kinase inhibitor in clinical development. J Hematol Oncol. 2018 Sep 19;11(1):120. DM3WP0N RU https://www.ncbi.nlm.nih.gov/pubmed/?term=30231931 DM3WP0N DI DM3WP0N DM3WP0N DN Al3818 DM3WP0N MI DEIBDNY DM3WP0N MN Cytochrome P450 3A5 (CYP3A5) DM3WP0N MT DME DM3WP0N MA Metabolism DM3WP0N RN Anlotinib: a novel multi-targeting tyrosine kinase inhibitor in clinical development. J Hematol Oncol. 2018 Sep 19;11(1):120. DM3WP0N RU https://www.ncbi.nlm.nih.gov/pubmed/?term=30231931 DM3WP0N DI DM3WP0N DM3WP0N DN Al3818 DM3WP0N MI TT6PKBN DM3WP0N MN Proto-oncogene c-Src (SRC) DM3WP0N MT DTT DM3WP0N MA Inhibitor DM3WP0N RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DM3WP0N RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DMK0QW6 DI DMK0QW6 DMK0QW6 DN Albinterferon alfa-2b DMK0QW6 MI TTSIUJ9 DMK0QW6 MN Interferon-alpha 2 (IFNA2) DMK0QW6 MT DTT DMK0QW6 MA Modulator DMK0QW6 RN Albinterferon alfa-2b, a novel fusion protein of human albumin and human interferon alfa-2b, for chronic hepatitis C. Curr Med Res Opin. 2009 Apr;25(4):991-1002. DMK0QW6 RU https://pubmed.ncbi.nlm.nih.gov/19275518 DMWAL73 DI DMWAL73 DMWAL73 DN Albutropin DMWAL73 MI TTT3YKH DMWAL73 MN Somatotropin (GH1) DMWAL73 MT DTT DMWAL73 MA Modulator DMWAL73 RN Albutropin: a growth hormone-albumin fusion with improved pharmacokinetics and pharmacodynamics in rats and monkeys. Eur J Pharmacol. 2002 Dec 5;456(1-3):149-58. DMWAL73 RU https://pubmed.ncbi.nlm.nih.gov/12450581 DMHKCIS DI DMHKCIS DMHKCIS DN Aldoxorubicin DMHKCIS MI TT0IHXV DMHKCIS MN DNA topoisomerase II (TOP2) DMHKCIS MT DTT DMHKCIS MA Modulator DMHKCIS RN Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41. DMHKCIS RU https://www.ncbi.nlm.nih.gov/pubmed/15950434 DMPH1RK DI DMPH1RK DMPH1RK DN Alferminogene tadenovec DMPH1RK MI TTCEKVZ DMPH1RK MN Fibroblast growth factor-4 (FGF4) DMPH1RK MT DTT DMPH1RK MA Modulator DMPH1RK RN Alferminogene tadenovec, an angiogenic FGF4 gene therapy for coronary artery disease. IDrugs. 2008 Apr;11(4):283-93. DMPH1RK RU https://pubmed.ncbi.nlm.nih.gov/18379964 DMVHRL8 DI DMVHRL8 DMVHRL8 DN Alfimeprase DMVHRL8 MI TTWODQF DMVHRL8 MN Fibrin (FG) DMVHRL8 MT DTT DMVHRL8 MA Modulator DMVHRL8 RN Disulfide structure of alfimeprase: A recombinant analog of fibrolase. Protein Sci. 2001 June; 10(6): 1264-1267. DMVHRL8 RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2374009/ DMBQK0X DI DMBQK0X DMBQK0X DN Algenpantucel-L DMBQK0X MI TTPJ1I3 DMBQK0X MN Galactosyltransferase (GALT) DMBQK0X MT DTT DMBQK0X RN Recent Treatment Advances and Novel Therapies in Pancreas Cancer: A Review. J Gastrointest Cancer. 2014; 45(2): 190-201. DMBQK0X RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4024386/ DMQ509J DI DMQ509J DMQ509J DN Alicaforsen DMQ509J MI TTA1L39 DMQ509J MN ICAM1 messenger RNA (ICAM1 mRNA) DMQ509J MT DTT DMQ509J RN Clinical pipeline report, company report or official report of ISIS Pharmaceuticals (2009). DMQ509J RU http://www.isispharm.com/Pipeline/index.htm DMQ509J DI DMQ509J DMQ509J DN Alicaforsen DMQ509J MI TTCT6F7 DMQ509J MN Intercellular adhesion molecule ICAM-1 (ICAM1) DMQ509J MT DTT DMQ509J MA Antagonist DMQ509J RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMQ509J RU http://phrma-docs.phrma.org/files/dmfile/medicines-in-development-drug-list-autoimmune-diseases.pdf DM9R2SD DI DM9R2SD DM9R2SD DN Alilusem DM9R2SD MI DTPFTEQ DM9R2SD MN Organic anion transporting polypeptide 2B1 (SLCO2B1) DM9R2SD MT DTP DM9R2SD MA Substrate DM9R2SD RN Characterization of the uptake mechanism for a novel loop diuretic, M17055, in Caco-2 cells: involvement of organic anion transporting polypeptide (OATP)-B. Pharm Res. 2007 Jan;24(1):90-8. DM9R2SD RU https://doi.org/10.1007/s11095-006-9127-x DM9R2SD DI DM9R2SD DM9R2SD DN Alilusem DM9R2SD MI TTYJL7K DM9R2SD MN Sodium/potassium transport (Na/K trans) DM9R2SD MT DTT DM9R2SD MA Modulator DM9R2SD RN US patent application no. 8,067,031, Compositions and systems for forming crosslinked biomaterials and associated methods of preparation and use. DM9R2SD RU http://www.google.lv/patents/US8067031 DM83EBP DI DM83EBP DM83EBP DN Alisporivir DM83EBP MI TTATDGJ DM83EBP MN Calcium signal-modulating cyclophilin ligand (CAML) DM83EBP MT DTT DM83EBP MA Inhibitor DM83EBP RN DEB025 (Alisporivir) inhibits hepatitis C virus replication by preventing a cyclophilin A induced cis-trans isomerisation in domain II of NS5A. PLoS One. 2010 Oct 27;5(10):e13687. DM83EBP RU https://pubmed.ncbi.nlm.nih.gov/21060866 DM83EBP DI DM83EBP DM83EBP DN Alisporivir DM83EBP MI DE4LYSA DM83EBP MN Cytochrome P450 3A4 (CYP3A4) DM83EBP MT DME DM83EBP MA Metabolism DM83EBP RN Profile of alisporivir and its potential in the treatment of hepatitis C. Drug Des Devel Ther. 2013;7:105-15. DM83EBP RU https://www.ncbi.nlm.nih.gov/pubmed/?term=23440335 DMCHA27 DI DMCHA27 DMCHA27 DN Almonertinib DMCHA27 MI TTGKNB4 DMCHA27 MN Epidermal growth factor receptor (EGFR) DMCHA27 MT DTT DMCHA27 MA Inhibitor DMCHA27 RN Safety, Efficacy, and Pharmacokinetics of Almonertinib (HS-10296) in Pretreated Patients With EGFR-Mutated Advanced NSCLC: A Multicenter, Open-label, Phase 1 Trial. J Thorac Oncol. 2020 Dec;15(12):1907-1918. DMCHA27 RU https://pubmed.ncbi.nlm.nih.gov/32916310 DMFUOM7 DI DMFUOM7 DMFUOM7 DN ALN-TTRsc DMFUOM7 MI TTC1I86 DMFUOM7 MN Transthyretin (TTR) DMFUOM7 MT DTT DMFUOM7 MA Inhibitor DMFUOM7 RN Clinical pipeline report, company report or official report of Alnylam Pharmaceuticals, Inc. DMFUOM7 RU http://www.alnylam.com/product-pipeline/ttr-amyloidosis-fap/ DMKLBHX DI DMKLBHX DMKLBHX DN ALO-02 DMKLBHX MI TTN4QDT DMKLBHX MN Opioid receptor (OPR) DMKLBHX MT DTT DMKLBHX MA Modulator DMKLBHX RN Adding ultralow-dose naltrexone to oxycodone enhances and prolongs analgesia: a randomized, controlled trial of Oxytrex. J Pain. 2005 Jun;6(6):392-9. DMKLBHX RU https://pubmed.ncbi.nlm.nih.gov/15943961 DM2RTGP DI DM2RTGP DM2RTGP DN Alpha-glucosidase DM2RTGP MI TTXWASR DM2RTGP MN Intestinal maltase-glucoamylase (MGAM) DM2RTGP MT DTT DM2RTGP MA Modulator DM2RTGP RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2627). DM2RTGP RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2627 DM7EBH9 DI DM7EBH9 DM7EBH9 DN ALX-0081 DM7EBH9 MI TT3SZBT DM7EBH9 MN von Willebrand factor (VWF) DM7EBH9 MT DTT DM7EBH9 MA Binder DM7EBH9 RN Clinical pipeline report, company report or official report of Ablynx DM7EBH9 RU http://hugin.info/137912/R/1338761/319541.pdf DMG5BTD DI DMG5BTD DMG5BTD DN ALZT-OP1 DMG5BTD MI TTE4KHA DMG5BTD MN Amyloid beta A4 protein (APP) DMG5BTD MT DTT DMG5BTD MA Inhibitor DMG5BTD RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMG5BTD RU http://phrma-docs.phrma.org/files/dmfile/MID-Update_Alzheimers-Disease_2017-Drug-List.pdf DMGMNUE DI DMGMNUE DMGMNUE DN AM0010 DMGMNUE MI TTT0Q1F DMGMNUE MN Interleukin-10 (IL10) DMGMNUE MT DTT DMGMNUE MA Modulator DMGMNUE RN Clinical pipeline report, company report or official report of ARMO BioSciences. DMGMNUE RU http://www.armobio.com/drug-development DM4E9PK DI DM4E9PK DM4E9PK DN AM-111 DM4E9PK MI TTR2TXZ DM4E9PK MN Jun N terminal kinase (JNK) DM4E9PK MT DTT DM4E9PK MA Modulator DM4E9PK RN The JNK inhibitor XG-102 protects against TNBS-induced colitis.PLoS One.2012;7(3):e30985. DM4E9PK RU https://www.ncbi.nlm.nih.gov/pubmed/22427801 DMVOY6B DI DMVOY6B DMVOY6B DN AMD-070 DMVOY6B MI TTBID49 DMVOY6B MN C-X-C chemokine receptor type 4 (CXCR4) DMVOY6B MT DTT DMVOY6B MA Antagonist DMVOY6B RN Pharmacokinetic effect of AMD070, an Oral CXCR4 antagonist, on CYP3A4 and CYP2D6 substrates midazolam and dextromethorphan in healthy volunteers. J Acquir Immune Defic Syndr. 2008 Apr 15;47(5):559-65. DMVOY6B RU https://pubmed.ncbi.nlm.nih.gov/18362694 DM4FPM3 DI DM4FPM3 DM4FPM3 DN Amediplase DM4FPM3 MI TTGY7WI DM4FPM3 MN Urokinase-type plasminogen activator (PLAU) DM4FPM3 MT DTT DM4FPM3 MA Activator DM4FPM3 RN Emerging drugs in peripheral arterial disease. Expert Opin Emerg Drugs. 2006 Mar;11(1):75-90. DM4FPM3 RU https://pubmed.ncbi.nlm.nih.gov/16503827 DMG324Y DI DMG324Y DMG324Y DN AMG 145 DMG324Y MI TTBRG7E DMG324Y MN Proprotein convertase subtilisin/kexin type 9 (PCSK9) DMG324Y MT DTT DMG324Y MA Modulator DMG324Y RN PCSK9 inhibition with evolocumab (AMG 145) in heterozygous familial hypercholesterolaemia (RUTHERFORD-2): a randomised, double-blind, placebo-controlled trial. Lancet. 2015 Jan 24;385(9965):331-40. DMG324Y RU https://pubmed.ncbi.nlm.nih.gov/25282519 DMQJXL4 DI DMQJXL4 DMQJXL4 DN AMG 386 DMQJXL4 MI TTWNQ1T DMQJXL4 MN Angiopoietin-1 (ANGPT1) DMQJXL4 MT DTT DMQJXL4 MA Modulator DMQJXL4 RN Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41. DMQJXL4 RU https://www.ncbi.nlm.nih.gov/pubmed/15950434 DMQJXL4 DI DMQJXL4 DMQJXL4 DN AMG 386 DMQJXL4 MI TTKLQTJ DMQJXL4 MN Angiopoietin-2 (ANGPT2) DMQJXL4 MT DTT DMQJXL4 MA Modulator DMQJXL4 RN Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41. DMQJXL4 RU https://www.ncbi.nlm.nih.gov/pubmed/15950434 DMQJXL4 DI DMQJXL4 DMQJXL4 DN AMG 386 DMQJXL4 MI TT9W8GU DMQJXL4 MN Gamma-secretase (GS) DMQJXL4 MT DTT DMQJXL4 MA Inhibitor DMQJXL4 RN Clinical pipeline report, company report or official report of Roche (2009). DMQJXL4 RU http://www.roche.com/research_and_development/pipeline/roche_pharma_pipeline.htm DMQJXL4 DI DMQJXL4 DMQJXL4 DN AMG 386 DMQJXL4 MI TTD0CIQ DMQJXL4 MN Melanocortin receptor 4 (MC4R) DMQJXL4 MT DTT DMQJXL4 MA Agonist DMQJXL4 RN Emerging drugs for obesity: linking novel biological mechanisms to pharmaceutical pipelines. Expert Opin Emerg Drugs. 2005 Aug;10(3):643-60. DMQJXL4 RU https://pubmed.ncbi.nlm.nih.gov/16083333 DMQJXL4 DI DMQJXL4 DMQJXL4 DN AMG 386 DMQJXL4 MI TTLA931 DMQJXL4 MN Neuronal acetylcholine receptor alpha-7 (CHRNA7) DMQJXL4 MT DTT DMQJXL4 MA Agonist DMQJXL4 RN Clinical pipeline report, company report or official report of Roche (2009). DMQJXL4 RU http://www.roche.com/research_and_development/pipeline/roche_pharma_pipeline.htm DMQJXL4 DI DMQJXL4 DMQJXL4 DN AMG 386 DMQJXL4 MI TTN4QDT DMQJXL4 MN Opioid receptor (OPR) DMQJXL4 MT DTT DMQJXL4 MA Agonist DMQJXL4 RN Emerging drugs in neuropathic pain. Expert Opin Emerg Drugs. 2007 Mar;12(1):113-26. DMQJXL4 RU https://pubmed.ncbi.nlm.nih.gov/17355217 DMQJXL4 DI DMQJXL4 DMQJXL4 DN AMG 386 DMQJXL4 MI TTBW580 DMQJXL4 MN TAX transcriptionally-activated glycoprotein 1 (OX40) DMQJXL4 MT DTT DMQJXL4 MA Modulator DMQJXL4 RN Clinical targeting of the TNF and TNFR superfamilies.Nat Rev Drug Discov.2013 Feb;12(2):147-68. DMQJXL4 RU https://www.ncbi.nlm.nih.gov/pubmed/23334208 DMS1X67 DI DMS1X67 DMS1X67 DN Amitifadine DMS1X67 MI TTVBI8W DMS1X67 MN Dopamine transporter (DAT) DMS1X67 MT DTT DMS1X67 MA Inhibitor DMS1X67 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 927). DMS1X67 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=927 DMS1X67 DI DMS1X67 DMS1X67 DN Amitifadine DMS1X67 MI TTAWNKZ DMS1X67 MN Norepinephrine transporter (NET) DMS1X67 MT DTT DMS1X67 MA Inhibitor DMS1X67 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 926). DMS1X67 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=926 DMS1X67 DI DMS1X67 DMS1X67 DN Amitifadine DMS1X67 MI TT3ROYC DMS1X67 MN Serotonin transporter (SERT) DMS1X67 MT DTT DMS1X67 MA Inhibitor DMS1X67 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 928). DMS1X67 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=928 DMF50XJ DI DMF50XJ DMF50XJ DN Amitriptyline+ketamine DMF50XJ MI TT9IK2Z DMF50XJ MN N-methyl-D-aspartate receptor (NMDAR) DMF50XJ MT DTT DMF50XJ MA Antagonist DMF50XJ RN Emerging drugs in neuropathic pain. Expert Opin Emerg Drugs. 2007 Mar;12(1):113-26. DMF50XJ RU https://pubmed.ncbi.nlm.nih.gov/17355217 DMZ7AMY DI DMZ7AMY DMZ7AMY DN Amivantamab DMZ7AMY MI TTGKNB4 DMZ7AMY MN Epidermal growth factor receptor (EGFR) DMZ7AMY MT DTT DMZ7AMY MA Inhibitor DMZ7AMY RN Antitumor Activity of Amivantamab (JNJ-61186372), an EGFR-MET Bispecific Antibody, in Diverse Models of EGFR Exon 20 Insertion-Driven NSCLC. Cancer Discov. 2020 Aug;10(8):1194-1209. DMZ7AMY RU https://pubmed.ncbi.nlm.nih.gov/32414908 DMZ7AMY DI DMZ7AMY DMZ7AMY DN Amivantamab DMZ7AMY MI TTNDSF4 DMZ7AMY MN Proto-oncogene c-Met (MET) DMZ7AMY MT DTT DMZ7AMY MA Inhibitor DMZ7AMY RN Antitumor Activity of Amivantamab (JNJ-61186372), an EGFR-MET Bispecific Antibody, in Diverse Models of EGFR Exon 20 Insertion-Driven NSCLC. Cancer Discov. 2020 Aug;10(8):1194-1209. DMZ7AMY RU https://pubmed.ncbi.nlm.nih.gov/32414908 DMB9587 DI DMB9587 DMB9587 DN Amocarzine DMB9587 MI TT1RS9F DMB9587 MN Acetylcholinesterase (AChE) DMB9587 MT DTT DMB9587 MA Inhibitor DMB9587 RN Activity, mechanism of action and pharmacokinetics of 2-tert-butylbenzothiazole and CGP 6140 (amocarzine) antifilarial drugs. Acta Trop. 1992 Aug;51(3-4):195-211. DMB9587 RU https://pubmed.ncbi.nlm.nih.gov/1359747 DM6SGUB DI DM6SGUB DM6SGUB DN Amrubicin DM6SGUB MI DE3N2FM DM6SGUB MN NADPH-cytochrome P450 reductase (CPR) DM6SGUB MT DME DM6SGUB MA Metabolism DM6SGUB RN Characterization of the enzymes involved in the in vitro metabolism of amrubicin hydrochloride. Xenobiotica. 2005 Dec;35(12):1121-33. DM6SGUB RU https://www.ncbi.nlm.nih.gov/pubmed/?term=16418065 DM8QIRN DI DM8QIRN DM8QIRN DN AMT-011 DM8QIRN MI TTOF3WZ DM8QIRN MN Lipoprotein lipase (LPL) DM8QIRN MT DTT DM8QIRN MA Modulator DM8QIRN RN Alipogene tiparvovec for the treatment of lipoprotein lipase deficiency. Drugs Today (Barc). 2013 Mar;49(3):161-70. DM8QIRN RU https://pubmed.ncbi.nlm.nih.gov/23527320 DMSO02K DI DMSO02K DMSO02K DN AMT-061 DMSO02K MI TTFEZ5Q DMSO02K MN Coagulation factor IX (F9) DMSO02K MT DTT DMSO02K RN Clinical pipeline report, company report or official report of uniQure. DMSO02K RU http://uniqure.com/gene-therapy/hemophilia.php DMP2BFG DI DMP2BFG DMP2BFG DN Anacetrapib DMP2BFG MI TTFQAYR DMP2BFG MN Cholesteryl ester transfer protein (CETP) DMP2BFG MT DTT DMP2BFG MA Inhibitor DMP2BFG RN Assessment of a pharmacokinetic and pharmacodynamic interaction between simvastatin and anacetrapib, a potent cholesteryl ester transfer protein (C... Br J Clin Pharmacol. 2009 May;67(5):520-6. DMP2BFG RU https://pubmed.ncbi.nlm.nih.gov/19552746 DMP2BFG DI DMP2BFG DMP2BFG DN Anacetrapib DMP2BFG MI DE4LYSA DMP2BFG MN Cytochrome P450 3A4 (CYP3A4) DMP2BFG MT DME DMP2BFG MA Metabolism DMP2BFG RN Metabolism and excretion of anacetrapib, a novel inhibitor of the cholesteryl ester transfer protein, in humans. Drug Metab Dispos. 2010 Mar;38(3):474-83. DMP2BFG RU https://www.ncbi.nlm.nih.gov/pubmed/?term=20016053 DM2F9YO DI DM2F9YO DM2F9YO DN Anakinra DM2F9YO MI TTT7FOP DM2F9YO MN HUMAN interleukin-1 receptor 1 (IL1R1) DM2F9YO MT DTT DM2F9YO MA Antagonist DM2F9YO RN FDA Approved Drug Products from FDA Official Website. 2019. Application Number: (BLA) 125166. DM2F9YO RU http://www.accessdata.fda.gov/scripts/cder/drugsatfda/index.cfm?fuseaction=Search.Addlsearch_drug_name DM6HXTS DI DM6HXTS DM6HXTS DN Anamorelin DM6HXTS MI TTHCF4J DM6HXTS MN Alpha-glucosidase (GLA) DM6HXTS MT DTT DM6HXTS MA Modulator DM6HXTS RN Absorption, elimination, and metabolism of CS-1036, a novel -amylase inhibitor in rats and monkeys, and the relationship between gastrointestinal distribution and suppression of glucose absorption.Drug Metab Dispos.2013 Apr;41(4):878-87. DM6HXTS RU https://www.ncbi.nlm.nih.gov/pubmed/23378626 DM6HXTS DI DM6HXTS DM6HXTS DN Anamorelin DM6HXTS MI TTWDC17 DM6HXTS MN Growth hormone secretagogue receptor 1 (GHSR) DM6HXTS MT DTT DM6HXTS MA Stimulator DM6HXTS RN Pharmacodynamic hormonal effects of anamorelin, a novel oral ghrelin mimetic and growth hormone secretagogue in healthy volunteers. Growth Horm IGF Res. 2009 Jun;19(3):267-73. DM6HXTS RU https://pubmed.ncbi.nlm.nih.gov/19196529 DMK2Y4V DI DMK2Y4V DMK2Y4V DN Ancrod DMK2Y4V MI TTZUXYS DMK2Y4V MN Vitamin K-dependent protein C (PROC) DMK2Y4V MT DTT DMK2Y4V MA Modulator DMK2Y4V RN Ancrod (Arvin) as an alternative to heparin anticoagulation for cardiopulmonary bypass. Anesthesiology. 1989 Dec;71(6):870-7. DMK2Y4V RU https://pubmed.ncbi.nlm.nih.gov/2589675 DMLDB1X DI DMLDB1X DMLDB1X DN Andecaliximab DMLDB1X MI TT6X50U DMLDB1X MN Matrix metalloproteinase-9 (MMP-9) DMLDB1X MT DTT DMLDB1X RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMLDB1X RU http://phrma-docs.phrma.org/files/dmfile/MID_Immuno-Oncology-2017_Drug-List1.pdf DMX36BH DI DMX36BH DMX36BH DN Andolast DMX36BH MI TT1VOHK DMX36BH MN Potassium channel unspecific (KC) DMX36BH MT DTT DMX36BH MA Opener DMX36BH RN BK channel modulators: a comprehensive overview. Curr Med Chem. 2008;15(11):1126-46. DMX36BH RU https://pubmed.ncbi.nlm.nih.gov/18473808 DMITJAK DI DMITJAK DMITJAK DN Androsterone DMITJAK MI DEOCWU3 DMITJAK MN Alcohol dehydrogenase class-II (ADH4) DMITJAK MT DME DMITJAK MA Metabolism DMITJAK RN 13-cis-retinoic acid competitively inhibits 3 alpha-hydroxysteroid oxidation by retinol dehydrogenase RoDH-4: a mechanism for its anti-androgenic effects in sebaceous glands? Biochem Biophys Res Commun. 2003 Mar 28;303(1):273-8. DMITJAK RU https://www.ncbi.nlm.nih.gov/pubmed/?term=12646198 DMITJAK DI DMITJAK DMITJAK DN Androsterone DMITJAK MI DEGQTXO DMITJAK MN Aldo-keto reductase 1C3 (AKR1C3) DMITJAK MT DME DMITJAK MA Metabolism DMITJAK RN Expression and characterization of four recombinant human dihydrodiol dehydrogenase isoforms: oxidation of trans-7, 8-dihydroxy-7,8-dihydrobenzo[a]pyrene to the activated o-quinone metabolite benzo[a]pyrene-7,8-dione. Biochemistry. 1998 May 12;37(19):6781-90. DMITJAK RU https://www.ncbi.nlm.nih.gov/pubmed/?term=9578563 DMITJAK DI DMITJAK DMITJAK DN Androsterone DMITJAK MI DER0XCH DMITJAK MN Farnesol dehydrogenase (AKR1B15) DMITJAK MT DME DMITJAK MA Metabolism DMITJAK RN Aldo-keto Reductase 1B15 (AKR1B15): a mitochondrial human aldo-keto reductase with activity toward steroids and 3-keto-acyl-CoA conjugates. J Biol Chem. 2015 Mar 6;290(10):6531-45. DMITJAK RU https://www.ncbi.nlm.nih.gov/pubmed/?term=25577493 DMITJAK DI DMITJAK DMITJAK DN Androsterone DMITJAK MI TTNJYV2 DMITJAK MN Gamma-aminobutyric acid receptor (GAR) DMITJAK MT DTT DMITJAK MA Inhibitor DMITJAK RN Neurosteroid analogues. 11. Alternative ring system scaffolds: gamma-aminobutyric acid receptor modulation and anesthetic actions of benz[f]indenes. J Med Chem. 2006 Jul 27;49(15):4595-605. DMITJAK RU https://pubmed.ncbi.nlm.nih.gov/16854065 DMITJAK DI DMITJAK DMITJAK DN Androsterone DMITJAK MI DESD26P DMITJAK MN UDP-glucuronosyltransferase 1A6 (UGT1A6) DMITJAK MT DME DMITJAK MA Metabolism DMITJAK RN Structural and functional studies of UDP-glucuronosyltransferases. Drug Metab Rev. 1999 Nov;31(4):817-99. DMITJAK RU https://www.ncbi.nlm.nih.gov/pubmed/?term=10575553 DM76GZ0 DI DM76GZ0 DM76GZ0 DN Angiotensin-(1-7) DM76GZ0 MI DEGPI81 DM76GZ0 MN Angiotensin-converting enzyme 2 (ACE2) DM76GZ0 MT DME DM76GZ0 MA Metabolism DM76GZ0 RN Metabolism of angiotensin-(1-7) by angiotensin-converting enzyme. Hypertension. 1998 Jan;31(1 Pt 2):362-7. DM76GZ0 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=9453329 DM76GZ0 DI DM76GZ0 DM76GZ0 DN Angiotensin-(1-7) DM76GZ0 MI TTOISYB DM76GZ0 MN Proto-oncogene Mas (MAS) DM76GZ0 MT DTT DM76GZ0 MA Agonist DM76GZ0 RN New therapeutic pathways in the RAS. J Renin Angiotensin Aldosterone Syst. 2012 Dec;13(4):505-8. DM76GZ0 RU https://pubmed.ncbi.nlm.nih.gov/23166114 DM3FPAQ DI DM3FPAQ DM3FPAQ DN Anifrolumab DM3FPAQ MI TTMQB37 DM3FPAQ MN Interferon alpha/beta receptor 2 (IFNAR2) DM3FPAQ MT DTT DM3FPAQ MA Antagonist DM3FPAQ RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DM3FPAQ RU http://phrma-docs.phrma.org/files/dmfile/medicines-in-development-drug-list-autoimmune-diseases.pdf DMX0PWV DI DMX0PWV DMX0PWV DN Anti-IL-23 DMX0PWV MI TT6H4QR DMX0PWV MN Interleukin 23 receptor (IL23R) DMX0PWV MT DTT DMX0PWV RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2293). DMX0PWV RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2293 DMUYOC8 DI DMUYOC8 DMUYOC8 DN AP12009 DMUYOC8 MI TTY9TWO DMUYOC8 MN Transforming growth factor beta 2 (TGFB2) DMUYOC8 MT DTT DMUYOC8 RN Design and development of antisense drugs. Expert Opin. Drug Discov. 2008 3(10):1189-1207. DMUYOC8 RU http://www.informahealthcare.com/doi/abs/10.1517/17460441.3.10.1177 DMD8QTC DI DMD8QTC DMD8QTC DN Apadenoson DMD8QTC MI TTM2AOE DMD8QTC MN Adenosine A2a receptor (ADORA2A) DMD8QTC MT DTT DMD8QTC MA Agonist DMD8QTC RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 3290). DMD8QTC RU http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=3290 DMVY0BU DI DMVY0BU DMVY0BU DN Apaziquone DMVY0BU MI TTUTN1I DMVY0BU MN Human Deoxyribonucleic acid (hDNA) DMVY0BU MT DTT DMVY0BU MA Modulator DMVY0BU RN EO9 (Apaziquone): from the clinic to the laboratory and back again DMVY0BU RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3569998 DMT0A3Y DI DMT0A3Y DMT0A3Y DN APD-334 DMT0A3Y MI TT9JZCK DMT0A3Y MN Sphingosine-1-phosphate receptor 1 (S1PR1) DMT0A3Y MT DTT DMT0A3Y MA Agonist DMT0A3Y RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMT0A3Y RU http://phrma-docs.phrma.org/files/dmfile/medicines-in-development-drug-list-autoimmune-diseases.pdf DM4HQ52 DI DM4HQ52 DM4HQ52 DN APL-2 DM4HQ52 MI TTJGY7A DM4HQ52 MN Complement C3 (CO3) DM4HQ52 MT DTT DM4HQ52 MA Inhibitor DM4HQ52 RN Anti-ageing pipeline starts to mature.Nat Rev Drug Discov. 2018 Sep;17(9):609-612. DM4HQ52 RU https://pubmed.ncbi.nlm.nih.gov/30072728 DMBRQF5 DI DMBRQF5 DMBRQF5 DN ApoC-III DMBRQF5 MI TT3GKN5 DMBRQF5 MN Lipase unspecific (LIP) DMBRQF5 MT DTT DMBRQF5 MA Inhibitor DMBRQF5 RN An ABC of apolipoprotein C-III: a clinically useful new cardiovascular risk factor Int J Clin Pract. 2008 May;62(5):799-809. DMBRQF5 RU https://pubmed.ncbi.nlm.nih.gov/18201179 DM1K78U DI DM1K78U DM1K78U DN Apricitabine DM1K78U MI TT84ETX DM1K78U MN Human immunodeficiency virus Reverse transcriptase (HIV RT) DM1K78U MT DTT DM1K78U MA Modulator DM1K78U RN Multiple-dose pharmacokinetics of apricitabine, a novel nucleoside reverse transcriptase inhibitor, in patients with HIV-1 infection. Clin Drug Investig. 2008;28(2):129-38. DM1K78U RU https://www.ncbi.nlm.nih.gov/pubmed/18211121 DM2YQK8 DI DM2YQK8 DM2YQK8 DN AR-301 DM2YQK8 MI TT5FLYB DM2YQK8 MN Staphylococcus Alpha-hemolysin (Stap-coc hly) DM2YQK8 MT DTT DM2YQK8 MA Inhibitor DM2YQK8 RN Clinical pipeline report, company report or official report of Aridis Pharmaceuticals. DM2YQK8 RU https://www.aridispharma.com/ar-301/ DMZB9RI DI DMZB9RI DMZB9RI DN Arabaclofen DMZB9RI MI TTDCVZW DMZB9RI MN Gamma-aminobutyric acid B receptor (GABBR) DMZB9RI MT DTT DMZB9RI MA Agonist DMZB9RI RN Impact of acamprosate on behavior and brain-derived neurotrophic factor: an open-label study in youth with fragile X syndrome. Psychopharmacology (Berl). 2013 Jul;228(1):75-84. DMZB9RI RU https://pubmed.ncbi.nlm.nih.gov/23436129 DMO628K DI DMO628K DMO628K DN Arbaclofen placarbil DMO628K MI TTEX6LM DMO628K MN GABA(A) receptor gamma-3 (GABRG3) DMO628K MT DTT DMO628K MA Agonist DMO628K RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMO628K RU http://phrma-docs.phrma.org/files/dmfile/MID_Mental-Illness-2017-Drug-List_Final.pdf DMO628K DI DMO628K DMO628K DN Arbaclofen placarbil DMO628K MI TTDCVZW DMO628K MN Gamma-aminobutyric acid B receptor (GABBR) DMO628K MT DTT DMO628K MA Modulator DMO628K RN Arbaclofen placarbil, a novel R-baclofen prodrug: improved absorption, distribution, metabolism, and elimination properties compared with R-baclofen.J Pharmacol Exp Ther.2009 Sep;330(3):911-21. DMO628K RU https://www.ncbi.nlm.nih.gov/pubmed/19502531 DMYNJHI DI DMYNJHI DMYNJHI DN Arc029 DMYNJHI MI DEVDYN7 DMYNJHI MN Cytochrome P450 2E1 (CYP2E1) DMYNJHI MT DME DMYNJHI MA Metabolism DMYNJHI RN Effect of nilvadipine, a dihydropyridine calcium antagonist, on cytochrome P450 activities in human hepatic microsomes. Biol Pharm Bull. 2004 Mar;27(3):415-7. DMYNJHI RU https://www.ncbi.nlm.nih.gov/pubmed/?term=14993813 DMYNJHI DI DMYNJHI DMYNJHI DN Arc029 DMYNJHI MI DE4LYSA DMYNJHI MN Cytochrome P450 3A4 (CYP3A4) DMYNJHI MT DME DMYNJHI MA Metabolism DMYNJHI RN Effect of nilvadipine, a dihydropyridine calcium antagonist, on cytochrome P450 activities in human hepatic microsomes. Biol Pharm Bull. 2004 Mar;27(3):415-7. DMYNJHI RU https://www.ncbi.nlm.nih.gov/pubmed/?term=14993813 DMYNJHI DI DMYNJHI DMYNJHI DN Arc029 DMYNJHI MI TTZIFHC DMYNJHI MN Voltage-gated calcium channel alpha Cav1.2 (CACNA1C) DMYNJHI MT DTT DMYNJHI MA Inhibitor DMYNJHI RN Dihydropyrimidines: novel calcium antagonists with potent and long-lasting vasodilative and antihypertensive activity. J Med Chem. 1989 Oct;32(10):2399-406. DMYNJHI RU https://pubmed.ncbi.nlm.nih.gov/2552119 DMYNJHI DI DMYNJHI DMYNJHI DN Arc029 DMYNJHI MI TT7RGTM DMYNJHI MN Voltage-gated calcium channel alpha Cav1.3 (CACNA1D) DMYNJHI MT DTT DMYNJHI MA Inhibitor DMYNJHI RN Dihydropyrimidines: novel calcium antagonists with potent and long-lasting vasodilative and antihypertensive activity. J Med Chem. 1989 Oct;32(10):2399-406. DMYNJHI RU https://pubmed.ncbi.nlm.nih.gov/2552119 DM180DM DI DM180DM DM180DM DN ARGX-113 DM180DM MI TTKLPHO DM180DM MN Neonatal Fc receptor (FCGRT) DM180DM MT DTT DM180DM MA Antagonist DM180DM RN Randomized phase 2 study of FcRn antagonist efgartigimod in generalized myasthenia gravis. Neurology. 2019 Jun 4;92(23):e2661-e2673. DM180DM RU https://pubmed.ncbi.nlm.nih.gov/31118245 DM84AD1 DI DM84AD1 DM84AD1 DN Arofylline DM84AD1 MI TTV5CGO DM84AD1 MN Phosphodiesterase 4 (PDE4) DM84AD1 MT DTT DM84AD1 MA Inhibitor DM84AD1 RN Emerging drugs for the treatment of chronic obstructive pulmonary disease. Expert Opin Emerg Drugs. 2006 May;11(2):275-91. DM84AD1 RU https://pubmed.ncbi.nlm.nih.gov/16634702 DM02BVQ DI DM02BVQ DM02BVQ DN ARQ-087 DM02BVQ MI TT0LF7H DM02BVQ MN Fibroblast growth factor receptor (FGFR) DM02BVQ MT DTT DM02BVQ MA Antagonist DM02BVQ RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DM02BVQ RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DM02BVQ DI DM02BVQ DM02BVQ DN ARQ-087 DM02BVQ MI TTRLW2X DM02BVQ MN Fibroblast growth factor receptor 1 (FGFR1) DM02BVQ MT DTT DM02BVQ MA Inhibitor DM02BVQ RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1808). DM02BVQ RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1808 DML61S4 DI DML61S4 DML61S4 DN ARQ-151 DML61S4 MI TTV5CGO DML61S4 MN Phosphodiesterase 4 (PDE4) DML61S4 MT DTT DML61S4 MA Inhibitor DML61S4 RN Trial of Roflumilast Cream for Chronic Plaque Psoriasis. N Engl J Med. 2020 Jul 16;383(3):229-239. DML61S4 RU https://pubmed.ncbi.nlm.nih.gov/32668113 DMD7XWS DI DMD7XWS DMD7XWS DN AS-013 DMD7XWS MI TTG1QMU DMD7XWS MN Prostaglandin E2 receptor EP1 (PTGER1) DMD7XWS MT DTT DMD7XWS MA Agonist DMD7XWS RN Effect of lipo-pro-prostaglandin E1, AS-013 on rat inner ear microcirculatory thrombosis. Prostaglandins Leukot Essent Fatty Acids. 1998 Sep;59(3):203-7. DMD7XWS RU https://pubmed.ncbi.nlm.nih.gov/9844994 DMIV1WR DI DMIV1WR DMIV1WR DN AS-12141 DMIV1WR MI DEVSIE6 DMIV1WR MN Glyceraldehyde-3-phosphate dehydrogenase (gap) DMIV1WR MT DME DMIV1WR MA Metabolism DMIV1WR RN Cloning, expression and characterization of a mucin-binding GAPDH from Lactobacillus acidophilus. Int J Biol Macromol. 2016 Oct;91:338-46. DMIV1WR RU https://pubmed.ncbi.nlm.nih.gov/27180300 DMK09D4 DI DMK09D4 DMK09D4 DN ASC09 + ritonavir DMK09D4 MI TT1D53B DMK09D4 MN COVID-19 3C-like protease (3CLpro) DMK09D4 MT DTT DMK09D4 MA Inhibitor DMK09D4 RN Coronavirus puts drug repurposing on the fast track. Nat Biotechnol. 2020 Apr;38(4):379-381. DMK09D4 RU https://pubmed.ncbi.nlm.nih.gov/32205870 DMWE3SC DI DMWE3SC DMWE3SC DN ASC09 + ritonavir + oseltamivir DMWE3SC MI TT1D53B DMWE3SC MN COVID-19 3C-like protease (3CLpro) DMWE3SC MT DTT DMWE3SC MA Inhibitor DMWE3SC RN Coronavirus puts drug repurposing on the fast track. Nat Biotechnol. 2020 Apr;38(4):379-381. DMWE3SC RU https://pubmed.ncbi.nlm.nih.gov/32205870 DMND3AB DI DMND3AB DMND3AB DN Asimadoline DMND3AB MI TTQW87Y DMND3AB MN Opioid receptor kappa (OPRK1) DMND3AB MT DTT DMND3AB MA Agonist DMND3AB RN Emerging drugs for irritable bowel syndrome. Expert Opin Emerg Drugs. 2006 May;11(2):293-313. DMND3AB RU https://pubmed.ncbi.nlm.nih.gov/16634703 DMND3AB DI DMND3AB DMND3AB DN Asimadoline DMND3AB MI DTUGYRD DMND3AB MN P-glycoprotein 1 (ABCB1) DMND3AB MT DTP DMND3AB MA Substrate DMND3AB RN Mammalian drug efflux transporters of the ATP binding cassette (ABC) family in multidrug resistance: A review of the past decade. Cancer Lett. 2016 Jan 1;370(1):153-64. DMND3AB RU http://www.ncbi.nlm.nih.gov/pubmed/26499806 DMVA8KU DI DMVA8KU DMVA8KU DN ASP0113 DMVA8KU MI TTK938H DMVA8KU MN Cytomegalovirus Deoxyribonucleic acid (CMV DNA) DMVA8KU MT DTT DMVA8KU RN VCL-CB01, an injectable bivalent plasmid DNA vaccine for potential protection against CMV disease and infection. Curr Opin Mol Ther. 2009 Oct;11(5):572-8. DMVA8KU RU https://pubmed.ncbi.nlm.nih.gov/19806506 DMZ1UOI DI DMZ1UOI DMZ1UOI DN Asp-015K DMZ1UOI MI TT6DM01 DMZ1UOI MN Janus kinase 1 (JAK-1) DMZ1UOI MT DTT DMZ1UOI MA Inhibitor DMZ1UOI RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2047). DMZ1UOI RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2047 DMZ1UOI DI DMZ1UOI DMZ1UOI DN Asp-015K DMZ1UOI MI TTT7PJU DMZ1UOI MN Janus kinase 3 (JAK-3) DMZ1UOI MT DTT DMZ1UOI MA Inhibitor DMZ1UOI RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2049). DMZ1UOI RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2049 DMZ1UOI DI DMZ1UOI DMZ1UOI DN Asp-015K DMZ1UOI MI DECVGJ3 DMZ1UOI MN Nicotinamide N-methyltransferase (NNMT) DMZ1UOI MT DME DMZ1UOI MA Metabolism DMZ1UOI RN Human mass balance, metabolite profile and identification of metabolic enzymes of [14C]ASP015K, a novel oral janus kinase inhibitor. Xenobiotica. 2015;45(10):887-902. DMZ1UOI RU https://www.ncbi.nlm.nih.gov/pubmed/?term=25986538 DMZ1UOI DI DMZ1UOI DMZ1UOI DN Asp-015K DMZ1UOI MI DE0P6LK DMZ1UOI MN Sulfotransferase 2A1 (SULT2A1) DMZ1UOI MT DME DMZ1UOI MA Metabolism DMZ1UOI RN Human mass balance, metabolite profile and identification of metabolic enzymes of [14C]ASP015K, a novel oral janus kinase inhibitor. Xenobiotica. 2015;45(10):887-902. DMZ1UOI RU https://www.ncbi.nlm.nih.gov/pubmed/?term=25986538 DMZ1UOI DI DMZ1UOI DMZ1UOI DN Asp-015K DMZ1UOI MI TTJSQEF DMZ1UOI MN Tyrosine-protein kinase (PTK) DMZ1UOI MT DTT DMZ1UOI MA Inhibitor DMZ1UOI RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMZ1UOI RU http://phrma-docs.phrma.org/files/dmfile/medicines-in-development-drug-list-autoimmune-diseases.pdf DMR71ST DI DMR71ST DMR71ST DN ASP1929 DMR71ST MI TTGKNB4 DMR71ST MN Epidermal growth factor receptor (EGFR) DMR71ST MT DTT DMR71ST MA Inhibitor DMR71ST RN ClinicalTrials.gov (NCT04305795) An Open-label Study Using ASP-1929 Photoimmunotherapy in Combination With Anti-PD1 Therapy in EGFR Expressing Advanced Solid Tumors. U.S. National Institutes of Health. DMR71ST RU https://clinicaltrials.gov/ct2/show/NCT04305795 DMGQ1TV DI DMGQ1TV DMGQ1TV DN ASP1941 DMGQ1TV MI TTLWPVF DMGQ1TV MN Sodium/glucose cotransporter 2 (SGLT2) DMGQ1TV MT DTT DMGQ1TV MA Modulator DMGQ1TV RN Ipragliflozin: A novel sodium-glucose cotransporter 2 inhibitor developed in Japan.World J Diabetes.2015 Feb 15;6(1):136-44. DMGQ1TV RU https://www.ncbi.nlm.nih.gov/pubmed/25685284 DM5N1OB DI DM5N1OB DM5N1OB DN Asp-2151 DM5N1OB MI DE4LYSA DM5N1OB MN Cytochrome P450 3A4 (CYP3A4) DM5N1OB MT DME DM5N1OB MA Metabolism DM5N1OB RN Amenamevir: studies of potential CYP3A-mediated pharmacokinetic interactions with midazolam, cyclosporine, and ritonavir in healthy volunteers. Clin Pharmacol Drug Dev. 2018 Nov;7(8):844-859. DM5N1OB RU https://www.ncbi.nlm.nih.gov/pubmed/?term=30044899 DM5N1OB DI DM5N1OB DM5N1OB DN Asp-2151 DM5N1OB MI TTKCVJR DM5N1OB MN Herpes simplex virus Helicase-primase (HSV UL8) DM5N1OB MT DTT DM5N1OB MA Inhibitor DM5N1OB RN Efficacy of ASP2151, a helicase-primase inhibitor, against thymidine kinase-deficient herpes simplex virus type 2 infection in vitro and in vivo. Antiviral Res. 2012 Feb;93(2):301-4. DM5N1OB RU https://pubmed.ncbi.nlm.nih.gov/22155691 DMLY0H5 DI DMLY0H5 DMLY0H5 DN Astuprotimut-R DMLY0H5 MI TTWSKHD DMLY0H5 MN Melanoma-associated antigen 3 (MAGEA3) DMLY0H5 MT DTT DMLY0H5 MA Modulator DMLY0H5 RN National Cancer Institute Drug Dictionary (drug id 600553). DMLY0H5 RU http://www.cancer.gov/publications/dictionaries/cancer-drug?cdrid=600553 DM4HK8Z DI DM4HK8Z DM4HK8Z DN ASTX727 DM4HK8Z MI TTHVCUP DM4HK8Z MN DNA [cytosine-5]-methyltransferase (DNMT) DM4HK8Z MT DTT DM4HK8Z MA Inhibitor DM4HK8Z RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DM4HK8Z RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DMRV4DT DI DMRV4DT DMRV4DT DN AT1001 DMRV4DT MI TTLC8E1 DMRV4DT MN Haptoglobin (HP) DMRV4DT MT DTT DMRV4DT MA Modulator DMRV4DT RN Zonulin, regulation of tight junctions, and autoimmune diseases DMRV4DT RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3384703 DMVJW0S DI DMVJW0S DMVJW0S DN AT-406 DMVJW0S MI TTQ5LRD DMVJW0S MN Cellular inhibitor of apoptosis 1 (BIRC2) DMVJW0S MT DTT DMVJW0S MA Inhibitor DMVJW0S RN Debio 1143, an antagonist of multiple inhibitor-of-apoptosis proteins, activates apoptosis and enhances radiosensitization of non-small cell lung c... Am J Cancer Res. 2014 Nov 19;4(6):943-51. DMVJW0S RU https://pubmed.ncbi.nlm.nih.gov/25520882 DMVJW0S DI DMVJW0S DMVJW0S DN AT-406 DMVJW0S MI TTIRY6K DMVJW0S MN Cellular inhibitor of apoptosis 2 (BIRC3) DMVJW0S MT DTT DMVJW0S MA Inhibitor DMVJW0S RN Debio 1143, an antagonist of multiple inhibitor-of-apoptosis proteins, activates apoptosis and enhances radiosensitization of non-small cell lung c... Am J Cancer Res. 2014 Nov 19;4(6):943-51. DMVJW0S RU https://pubmed.ncbi.nlm.nih.gov/25520882 DMVJW0S DI DMVJW0S DMVJW0S DN AT-406 DMVJW0S MI TTS74QB DMVJW0S MN Inhibitor of apoptosis protein (hIAP) DMVJW0S MT DTT DMVJW0S MA Modulator DMVJW0S RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7729). DMVJW0S RU http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=7729 DMVJW0S DI DMVJW0S DMVJW0S DN AT-406 DMVJW0S MI TTR7B60 DMVJW0S MN X-linked inhibitor of apoptosis protein (XIAP) DMVJW0S MT DTT DMVJW0S MA Inhibitor DMVJW0S RN Debio 1143, an antagonist of multiple inhibitor-of-apoptosis proteins, activates apoptosis and enhances radiosensitization of non-small cell lung c... Am J Cancer Res. 2014 Nov 19;4(6):943-51. DMVJW0S RU https://pubmed.ncbi.nlm.nih.gov/25520882 DMQ94CT DI DMQ94CT DMQ94CT DN AT9283 DMQ94CT MI TTPS3C0 DMQ94CT MN Aurora kinase A (AURKA) DMQ94CT MT DTT DMQ94CT MA Modulator DMQ94CT RN A phase I trial of AT9283 (a selective inhibitor of aurora kinases) in children and adolescents with solid tumors: a Cancer Research UK study. Clin Cancer Res. 2015 Jan 15;21(2):267-73. DMQ94CT RU https://pubmed.ncbi.nlm.nih.gov/25370467 DMQ94CT DI DMQ94CT DMQ94CT DN AT9283 DMQ94CT MI TT5LS6T DMQ94CT MN Aurora kinase B (AURKB) DMQ94CT MT DTT DMQ94CT MA Modulator DMQ94CT RN A phase I trial of AT9283 (a selective inhibitor of aurora kinases) in children and adolescents with solid tumors: a Cancer Research UK study. Clin Cancer Res. 2015 Jan 15;21(2):267-73. DMQ94CT RU https://pubmed.ncbi.nlm.nih.gov/25370467 DM8GFEV DI DM8GFEV DM8GFEV DN Atacicept DM8GFEV MI TTOI1RM DM8GFEV MN A proliferation-inducing ligand (APRIL) DM8GFEV MT DTT DM8GFEV MA Modulator DM8GFEV RN Atacicept: a new B lymphocyte-targeted therapy for multiple sclerosis. Nervenarzt. 2009 Dec;80(12):1462-72. DM8GFEV RU https://pubmed.ncbi.nlm.nih.gov/19779889 DM4GXW3 DI DM4GXW3 DM4GXW3 DN Ataluren DM4GXW3 MI TT2TNRM DM4GXW3 MN Dystrophin nonsense mutant (DMD) DM4GXW3 MT DTT DM4GXW3 MA Modulator DM4GXW3 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7341). DM4GXW3 RU http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=7341 DM4GXW3 DI DM4GXW3 DM4GXW3 DN Ataluren DM4GXW3 MI DE85D2P DM4GXW3 MN UDP-glucuronosyltransferase 1A9 (UGT1A9) DM4GXW3 MT DME DM4GXW3 MA Metabolism DM4GXW3 RN Ataluren pharmacokinetics in healthy Japanese and Caucasian subjects. Clin Pharmacol Drug Dev. 2019 Feb;8(2):172-178. DM4GXW3 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=30629861 DM3QLK2 DI DM3QLK2 DM3QLK2 DN Atamestane + Toremifene DM3QLK2 MI TTSZLWK DM3QLK2 MN Aromatase (CYP19A1) DM3QLK2 MT DTT DM3QLK2 MA Modulator DM3QLK2 RN Toremifene-atamestane; alone or in combination: predictions from the preclinical intratumoral aromatase model. J Steroid Biochem Mol Biol. 2008 Jan;108(1-2):1-7. DM3QLK2 RU https://pubmed.ncbi.nlm.nih.gov/17942301 DM4VJ5Q DI DM4VJ5Q DM4VJ5Q DN ATG-Fresenius S DM4VJ5Q MI TTXQYT6 DM4VJ5Q MN T-cells (T-cells) DM4VJ5Q MT DTT DM4VJ5Q RN Clinical pipeline report, company report or official report of Neovii Biotech. DM4VJ5Q RU http://www.neoviibiotech.com/products-and-pipeline/atg-fresenius.html DMBR0QK DI DMBR0QK DMBR0QK DN Atorvastatin DMBR0QK MI TTDJB68 DMBR0QK MN HUMAN MYD88NF-kappa-B proinflammatory pathway (MYD88-NFKB pathway) DMBR0QK MT DTT DMBR0QK MA Inhibitor DMBR0QK RN Statin therapy in COVID-19 infection. Eur Heart J Cardiovasc Pharmacother. 2020 Apr 29. pii: pvaa042. DMBR0QK RU https://pubmed.ncbi.nlm.nih.gov/32347925 DMM74PK DI DMM74PK DMM74PK DN Atrasentan DMM74PK MI DE4LYSA DMM74PK MN Cytochrome P450 3A4 (CYP3A4) DMM74PK MT DME DMM74PK MA Metabolism DMM74PK RN Organic anion transporting polypeptide 1B1 activity classified by SLCO1B1 genotype influences atrasentan pharmacokinetics. Clin Pharmacol Ther. 2006 Mar;79(3):186-96. DMM74PK RU https://www.ncbi.nlm.nih.gov/pubmed/?term=16513443 DMM74PK DI DMM74PK DMM74PK DN Atrasentan DMM74PK MI TTKRD0G DMM74PK MN Endothelin A receptor (EDNRA) DMM74PK MT DTT DMM74PK MA Antagonist DMM74PK RN Effects of a selective ET(A)-receptor antagonist, atrasentan (ABT-627), in murine models of allergic asthma: demonstration of mouse strain specificity. Clin Sci (Lond). 2002 Aug;103 Suppl 48:367S-370S. DMM74PK RU https://pubmed.ncbi.nlm.nih.gov/12193124 DMM74PK DI DMM74PK DMM74PK DN Atrasentan DMM74PK MI DTE2B1D DMM74PK MN Organic anion transporting polypeptide 1A2 (SLCO1A2) DMM74PK MT DTP DMM74PK MA Substrate DMM74PK RN Organic anion transporting polypeptide 1B1 activity classified by SLCO1B1 genotype influences atrasentan pharmacokinetics. Clin Pharmacol Ther. 2006 Mar;79(3):186-96. DMM74PK RU https://doi.org/10.1016/j.clpt.2005.11.003 DMM74PK DI DMM74PK DMM74PK DN Atrasentan DMM74PK MI DT3D8F0 DMM74PK MN Organic anion transporting polypeptide 1B1 (SLCO1B1) DMM74PK MT DTP DMM74PK MA Substrate DMM74PK RN Organic anion transporting polypeptide 1B1: a genetically polymorphic transporter of major importance for hepatic drug uptake. Pharmacol Rev. 2011 Mar;63(1):157-81. DMM74PK RU http://www.ncbi.nlm.nih.gov/pubmed/21245207 DMM74PK DI DMM74PK DMM74PK DN Atrasentan DMM74PK MI DT9C1TS DMM74PK MN Organic anion transporting polypeptide 1B3 (SLCO1B3) DMM74PK MT DTP DMM74PK MA Substrate DMM74PK RN Organic anion transporting polypeptide 1B1 activity classified by SLCO1B1 genotype influences atrasentan pharmacokinetics. Clin Pharmacol Ther. 2006 Mar;79(3):186-96. DMM74PK RU https://doi.org/10.1016/j.clpt.2005.11.003 DM64WYC DI DM64WYC DM64WYC DN Atx-101 DM64WYC MI TTLG1PD DM64WYC MN Proliferating cell nuclear antigen (PCNA) DM64WYC MT DTT DM64WYC MA Immunomodulator DM64WYC RN Targeting proliferating cell nuclear antigen and its protein interactions induces apoptosis in multiple myeloma cells. PLoS One. 2013 Jul 31;8(7):e70430. DM64WYC RU https://pubmed.ncbi.nlm.nih.gov/23936203 DM0EQ9X DI DM0EQ9X DM0EQ9X DN Av 133 DM0EQ9X MI TTNZRI3 DM0EQ9X MN Synaptic vesicle amine transporter (SLC18A2) DM0EQ9X MT DTT DM0EQ9X MA Enhancer DM0EQ9X RN Brain imaging of vesicular monoamine transporter type 2 in healthy aging subjects by 18F-FP-(+)-DTBZ PET. PLoS One. 2013 Sep 30;8(9):e75952. DM0EQ9X RU https://pubmed.ncbi.nlm.nih.gov/24098749 DMPW5UF DI DMPW5UF DMPW5UF DN Avalglucosidase alfa DMPW5UF MI TTLPC70 DMPW5UF MN Lysosomal alpha-glucosidase (GAA) DMPW5UF MT DTT DMPW5UF MA Replacement DMPW5UF RN ClinicalTrials.gov (NCT02782741) Study to Compare the Efficacy and Safety of Enzyme Replacement Therapies Avalglucosidase Alfa and Alglucosidase Alfa Administered Every Other Week in Patients With Late-onset Pompe Disease Who Have Not Been Previously Treated for Pompe Disease (COMET). U.S. National Institutes of Health. DMPW5UF RU https://clinicaltrials.gov/ct2/show/NCT02782741 DMA86FL DI DMA86FL DMA86FL DN Avastin+/-Tarceva DMA86FL MI TT2J34L DMA86FL MN Arachidonate 5-lipoxygenase (5-LOX) DMA86FL MT DTT DMA86FL MA Inhibitor DMA86FL RN Simple analogues of anthralin: unusual specificity of structure and antiproliferative activity. J Med Chem. 1997 Nov 7;40(23):3773-80. DMA86FL RU https://pubmed.ncbi.nlm.nih.gov/9371243 DMA86FL DI DMA86FL DMA86FL DN Avastin+/-Tarceva DMA86FL MI TTG8HIM DMA86FL MN Dual specificity protein phosphatase 1 (DUSP1) DMA86FL MT DTT DMA86FL MA Inhibitor DMA86FL RN Bioactivities of simplified adociaquinone B and naphthoquinone derivatives against Cdc25B, MKP-1, and MKP-3 phosphatases. Bioorg Med Chem. 2009 Mar 15;17(6):2276-81. DMA86FL RU https://pubmed.ncbi.nlm.nih.gov/19028102 DMA86FL DI DMA86FL DMA86FL DN Avastin+/-Tarceva DMA86FL MI TTZJYKH DMA86FL MN Indoleamine 2,3-dioxygenase 1 (IDO1) DMA86FL MT DTT DMA86FL MA Inhibitor DMA86FL RN Indoleamine 2,3-dioxygenase is the anticancer target for a novel series of potent naphthoquinone-based inhibitors. J Med Chem. 2008 Mar 27;51(6):1706-18. DMA86FL RU https://pubmed.ncbi.nlm.nih.gov/18318466 DMA86FL DI DMA86FL DMA86FL DN Avastin+/-Tarceva DMA86FL MI TTR0SWN DMA86FL MN M-phase inducer phosphatase 2 (MPIP2) DMA86FL MT DTT DMA86FL MA Inhibitor DMA86FL RN Bioactivities of simplified adociaquinone B and naphthoquinone derivatives against Cdc25B, MKP-1, and MKP-3 phosphatases. Bioorg Med Chem. 2009 Mar 15;17(6):2276-81. DMA86FL RU https://pubmed.ncbi.nlm.nih.gov/19028102 DMA86FL DI DMA86FL DMA86FL DN Avastin+/-Tarceva DMA86FL MI TT3PQ2Y DMA86FL MN Plasmodium Dihydroorotate dehydrogenase (Malaria DHOdehase) DMA86FL MT DTT DMA86FL MA Inhibitor DMA86FL RN Kinetics of inhibition of human and rat dihydroorotate dehydrogenase by atovaquone, lawsone derivatives, brequinar sodium and polyporic acid. Chem Biol Interact. 2000 Jan 3;124(1):61-76. DMA86FL RU https://pubmed.ncbi.nlm.nih.gov/10658902 DMA86FL DI DMA86FL DMA86FL DN Avastin+/-Tarceva DMA86FL MI TTJNTSI DMA86FL MN Rotamase Pin1 (PIN1) DMA86FL MT DTT DMA86FL MA Inhibitor DMA86FL RN Overexpression of PIN1 Enhances Cancer Growth and Aggressiveness with Cyclin D1 Induction in EBV-Associated Nasopharyngeal Carcinoma.PLoS One. 2016 Jun 3;11(6):e0156833. DMA86FL RU https://pubmed.ncbi.nlm.nih.gov/27258148 DMA86FL DI DMA86FL DMA86FL DN Avastin+/-Tarceva DMA86FL MI TTOHSBA DMA86FL MN Vascular endothelial growth factor A (VEGFA) DMA86FL MT DTT DMA86FL MA Inhibitor DMA86FL RN Clinical pipeline report, company report or official report of Genentech (2009). DMA86FL RU http://www.gene.com/gene/pipeline/status/ DMRJK3U DI DMRJK3U DMRJK3U DN Avotermin DMRJK3U MI TTWOMY8 DMRJK3U MN Transforming growth factor beta 3 (TGFB3) DMRJK3U MT DTT DMRJK3U MA Modulator DMRJK3U RN Discovery and development of avotermin (recombinant human transforming growth factor beta 3): a new class of prophylactic therapeutic for the improvement of scarring. Wound Repair Regen. 2011 Sep;19 Suppl 1:s38-48. DMRJK3U RU https://pubmed.ncbi.nlm.nih.gov/21793965 DMV1SOR DI DMV1SOR DMV1SOR DN AVP-786 DMV1SOR MI TT5TPI6 DMV1SOR MN Opioid receptor sigma 1 (OPRS1) DMV1SOR MT DTT DMV1SOR MA Modulator DMV1SOR RN Antitussives and substance abuse. Subst Abuse Rehabil. 2013 Nov 6;4:75-82. DMV1SOR RU https://pubmed.ncbi.nlm.nih.gov/24648790 DMV1SOR DI DMV1SOR DMV1SOR DN AVP-786 DMV1SOR MI TT3ROYC DMV1SOR MN Serotonin transporter (SERT) DMV1SOR MT DTT DMV1SOR MA Modulator DMV1SOR RN Antitussives and substance abuse. Subst Abuse Rehabil. 2013 Nov 6;4:75-82. DMV1SOR RU https://pubmed.ncbi.nlm.nih.gov/24648790 DM6WZG8 DI DM6WZG8 DM6WZG8 DN AXS-05 DM6WZG8 MI TT9IK2Z DM6WZG8 MN N-methyl-D-aspartate receptor (NMDAR) DM6WZG8 MT DTT DM6WZG8 MA Antagonist DM6WZG8 RN Clinical pipeline report, company report or official report of Axsome Therapeutics. DM6WZG8 RU https://axsome.com/axs-pipeline/about-axs-05/ DMM6G5D DI DMM6G5D DMM6G5D DN AZD0914 DMM6G5D MI TTN6J5F DMM6G5D MN Bacterial DNA gyrase (Bact gyrase) DMM6G5D MT DTT DMM6G5D MA Modulator DMM6G5D RN High in vitro activity of the novel spiropyrimidinetrione AZD0914, a DNA gyrase inhibitor, against multidrug-resistant Neisseria gonorrhoeae isolates suggests a new effective option for oral treatment of gonorrhea.Antimicrob Agents Chemother.2014 Sep;58(9):5585-8. DMM6G5D RU https://www.ncbi.nlm.nih.gov/pubmed/24982070 DM9SKW8 DI DM9SKW8 DM9SKW8 DN AZD5363 DM9SKW8 MI TTWTSCV DM9SKW8 MN RAC-alpha serine/threonine-protein kinase (AKT1) DM9SKW8 MT DTT DM9SKW8 MA Inhibitor DM9SKW8 RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DM9SKW8 RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DM9SKW8 DI DM9SKW8 DM9SKW8 DN AZD5363 DM9SKW8 MI TTAZ05C DM9SKW8 MN RAC-gamma serine/threonine-protein kinase (AKT3) DM9SKW8 MT DTT DM9SKW8 MA Modulator DM9SKW8 RN The novel AKT inhibitor afuresertib shows favorable safety, pharmacokinetics, and clinical activity in multiple myeloma. Blood. 2014 Oct 2;124(14):2190-5. DM9SKW8 RU https://pubmed.ncbi.nlm.nih.gov/25075128 DMLY9F1 DI DMLY9F1 DMLY9F1 DN Azetirelin DMLY9F1 MI TT4J8MF DMLY9F1 MN Thyrotropin-releasing hormone receptor (TRHR) DMLY9F1 MT DTT DMLY9F1 MA Modulator DMLY9F1 RN Intestinal absorption of azetirelin, a new thyrotropin-releasing hormone (TRH) analogue. II. In situ and in vitro absorption characteristics of azetirelin from the rat intestine. Biol Pharm Bull. 1995 Jul;18(7):976-9. DMLY9F1 RU https://pubmed.ncbi.nlm.nih.gov/7581253 DMLY9F1 DI DMLY9F1 DMLY9F1 DN Azetirelin DMLY9F1 MI DEIZ2D9 DMLY9F1 MN Tripeptidase (pepT) DMLY9F1 MT DME DMLY9F1 MA Metabolism DMLY9F1 RN Metabolism of azetirelin, a new thyrotropin-releasing hormone (TRH) analogue, by intestinal microorganisms. Pharm Res. 1997 Aug;14(8):1004-7. DMLY9F1 RU https://pubmed.ncbi.nlm.nih.gov/9279880 DMUIBV8 DI DMUIBV8 DMUIBV8 DN Azimilide DMUIBV8 MI DECB0K3 DMUIBV8 MN Cytochrome P450 2D6 (CYP2D6) DMUIBV8 MT DME DMUIBV8 MA Metabolism DMUIBV8 RN The metabolic profile of azimilide in man: in vivo and in vitro evaluations. J Pharm Sci. 2005 Sep;94(9):2084-95. DMUIBV8 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=16052551 DMUIBV8 DI DMUIBV8 DMUIBV8 DN Azimilide DMUIBV8 MI DE4LYSA DMUIBV8 MN Cytochrome P450 3A4 (CYP3A4) DMUIBV8 MT DME DMUIBV8 MA Metabolism DMUIBV8 RN The metabolic profile of azimilide in man: in vivo and in vitro evaluations. J Pharm Sci. 2005 Sep;94(9):2084-95. DMUIBV8 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=16052551 DMUIBV8 DI DMUIBV8 DMUIBV8 DN Azimilide DMUIBV8 MI DEIBDNY DMUIBV8 MN Cytochrome P450 3A5 (CYP3A5) DMUIBV8 MT DME DMUIBV8 MA Metabolism DMUIBV8 RN The metabolic profile of azimilide in man: in vivo and in vitro evaluations. J Pharm Sci. 2005 Sep;94(9):2084-95. DMUIBV8 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=16052551 DMUIBV8 DI DMUIBV8 DMUIBV8 DN Azimilide DMUIBV8 MI TT1VOHK DMUIBV8 MN Potassium channel unspecific (KC) DMUIBV8 MT DTT DMUIBV8 MA Modulator DMUIBV8 RN Azimilide. Drugs. 2000 Feb;59(2):271-7; discussion 278-9. DMUIBV8 RU https://www.ncbi.nlm.nih.gov/pubmed/10730550 DM5Y4Q2 DI DM5Y4Q2 DM5Y4Q2 DN Azithromycin + hydroxychloroquine DM5Y4Q2 MI TTZGK1R DM5Y4Q2 MN HUMAN glycosylation of host receptor (GHR) DM5Y4Q2 MT DTT DM5Y4Q2 MA Inhibitor DM5Y4Q2 RN Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro. Cell Res. 2020 Mar;30(3):269-271. DM5Y4Q2 RU https://pubmed.ncbi.nlm.nih.gov/32020029 DM5Y4Q2 DI DM5Y4Q2 DM5Y4Q2 DN Azithromycin + hydroxychloroquine DM5Y4Q2 MI TTD16BI DM5Y4Q2 MN HUMAN pH-dependent viral fusion/replication (pH-DVF/R) DM5Y4Q2 MT DTT DM5Y4Q2 MA Inhibitor DM5Y4Q2 RN Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro. Cell Res. 2020 Mar;30(3):269-271. DM5Y4Q2 RU https://pubmed.ncbi.nlm.nih.gov/32020029 DM5Y4Q2 DI DM5Y4Q2 DM5Y4Q2 DN Azithromycin + hydroxychloroquine DM5Y4Q2 MI TT3A1EZ DM5Y4Q2 MN HUMAN toll-like receptor 7/9 signalling pathway (TLR7/9 pathway) DM5Y4Q2 MT DTT DM5Y4Q2 MA Inhibitor DM5Y4Q2 RN Mechanisms of action of hydroxychloroquine and chloroquine: implications for rheumatology. Nat Rev Rheumatol. 2020 Mar;16(3):155-166. DM5Y4Q2 RU https://pubmed.ncbi.nlm.nih.gov/32034323 DMPV6B2 DI DMPV6B2 DMPV6B2 DN BA-058 DMPV6B2 MI TTEPJL5 DMPV6B2 MN Parathyroid hormone receptor (PTH2R) DMPV6B2 MT DTT DMPV6B2 MA Modulator DMPV6B2 RN Emerging therapies for the treatment of osteoporosis. J Midlife Health. 2013 Jul-Sep; 4(3): 147-152. DMPV6B2 RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3952405/ DMXBHR6 DI DMXBHR6 DMXBHR6 DN Balaglitazone DMXBHR6 MI DES5XRU DMXBHR6 MN Cytochrome P450 2C8 (CYP2C8) DMXBHR6 MT DME DMXBHR6 MA Metabolism DMXBHR6 RN Effects of gemfibrozil, itraconazole, and their combination on the pharmacokinetics of pioglitazone. Clin Pharmacol Ther. 2005 May;77(5):404-14. DMXBHR6 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=15900286 DMXBHR6 DI DMXBHR6 DMXBHR6 DN Balaglitazone DMXBHR6 MI DE4LYSA DMXBHR6 MN Cytochrome P450 3A4 (CYP3A4) DMXBHR6 MT DME DMXBHR6 MA Metabolism DMXBHR6 RN Effects of gemfibrozil, itraconazole, and their combination on the pharmacokinetics of pioglitazone. Clin Pharmacol Ther. 2005 May;77(5):404-14. DMXBHR6 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=15900286 DMXBHR6 DI DMXBHR6 DMXBHR6 DN Balaglitazone DMXBHR6 MI TTZMAO3 DMXBHR6 MN Peroxisome proliferator-activated receptor gamma (PPAR-gamma) DMXBHR6 MT DTT DMXBHR6 MA Modulator DMXBHR6 RN Balaglitazone: a second generation peroxisome proliferator-activated receptor (PPAR) gamma () agonist.Mini Rev Med Chem.2012 Feb;12(2):87-97. DMXBHR6 RU https://www.ncbi.nlm.nih.gov/pubmed/22372600 DMUOFAC DI DMUOFAC DMUOFAC DN Balixafortide DMUOFAC MI TTBID49 DMUOFAC MN C-X-C chemokine receptor type 4 (CXCR4) DMUOFAC MT DTT DMUOFAC MA Antagonist DMUOFAC RN Anti-ageing pipeline starts to mature.Nat Rev Drug Discov. 2018 Sep;17(9):609-612. DMUOFAC RU https://pubmed.ncbi.nlm.nih.gov/30072728 DMKMTDG DI DMKMTDG DMKMTDG DN Balovaptan DMKMTDG MI TT4TFGN DMKMTDG MN Vasopressin V1a receptor (V1AR) DMKMTDG MT DTT DMKMTDG MA Antagonist DMKMTDG RN Discovery of Balovaptan, a Vasopressin 1a Receptor Antagonist for the Treatment of Autism Spectrum Disorder. J Med Chem. 2020 Feb 27;63(4):1511-1525. DMKMTDG RU https://pubmed.ncbi.nlm.nih.gov/31951127 DMHQ5GK DI DMHQ5GK DMHQ5GK DN Bapineuzumab DMHQ5GK MI TTE4KHA DMHQ5GK MN Amyloid beta A4 protein (APP) DMHQ5GK MT DTT DMHQ5GK RN Bapineuzumab: anti-beta-amyloid monoclonal antibodies for the treatment of Alzheimer's disease. Immunotherapy. 2010 Nov;2(6):767-82. DMHQ5GK RU https://pubmed.ncbi.nlm.nih.gov/21091109 DMODA2X DI DMODA2X DMODA2X DN Bardoxolone methyl DMODA2X MI TTT2SVW DMODA2X MN PPAR-gamma messenger RNA (PPARG mRNA) DMODA2X MT DTT DMODA2X MA Antagonist DMODA2X RN A synthetic triterpenoid, 2-cyano-3,12-dioxooleana-1,9-dien-28-oic acid (CDDO), is a ligand for the peroxisome proliferator-activated receptor gamma. Mol Endocrinol. 2000 Oct;14(10):1550-6. DMODA2X RU https://pubmed.ncbi.nlm.nih.gov/11043571 DMPRI14 DI DMPRI14 DMPRI14 DN Baricitinib DMPRI14 MI TTN9A16 DMPRI14 MN HUMAN adaptor-associated kinase 1 (AAK1) DMPRI14 MT DTT DMPRI14 MA Inhibitor DMPRI14 RN Baricitinib as potential treatment for 2019-nCoV acute respiratory disease. Lancet. 2020 Feb 15;395(10223):e30-e31. DMPRI14 RU https://pubmed.ncbi.nlm.nih.gov/32032529 DMPRI14 DI DMPRI14 DMPRI14 DN Baricitinib DMPRI14 MI TT0AGBL DMPRI14 MN HUMAN cyclin G-associated kinase (GAK) DMPRI14 MT DTT DMPRI14 MA Inhibitor DMPRI14 RN Baricitinib as potential treatment for 2019-nCoV acute respiratory disease. Lancet. 2020 Feb 15;395(10223):e30-e31. DMPRI14 RU https://pubmed.ncbi.nlm.nih.gov/32032529 DMB147A DI DMB147A DMB147A DN BAX-817 DMB147A MI TTF0EGX DMB147A MN Coagulation factor VII (F7) DMB147A MT DTT DMB147A MA Inhibitor DMB147A RN Clinical pipeline report, company report or official report of Baxter. DMB147A RU http://investor.baxter.com/phoenix.zhtml?c=86121&p=irol-newsArticle&id=2025563 DM407I6 DI DM407I6 DM407I6 DN BAY 853934 DM407I6 MI TTJQFBG DM407I6 MN HIF-prolyl hydroxylase (HPH) DM407I6 MT DTT DM407I6 MA Inhibitor DM407I6 RN Discovery of Molidustat (BAY 85-3934): A Small-Molecule Oral HIF-Prolyl Hydroxylase (HIF-PH) Inhibitor for the Treatment of Renal Anemia. ChemMedChem. 2018 May 23;13(10):988-1003. DM407I6 RU https://pubmed.ncbi.nlm.nih.gov/29485740 DMPW5SB DI DMPW5SB DMPW5SB DN Bay 86-9766 DMPW5SB MI DE4LYSA DMPW5SB MN Cytochrome P450 3A4 (CYP3A4) DMPW5SB MT DME DMPW5SB MA Metabolism DMPW5SB RN Multicenter phase I trial of the mitogen-activated protein kinase 1/2 inhibitor BAY 86-9766 in patients with advanced cancer. Clin Cancer Res. 2013 Mar 1;19(5):1232-43. DMPW5SB RU https://www.ncbi.nlm.nih.gov/pubmed/?term=23434733 DMPW5SB DI DMPW5SB DMPW5SB DN Bay 86-9766 DMPW5SB MI TTROQ37 DMPW5SB MN MAPK/ERK kinase kinase (MAP3K) DMPW5SB MT DTT DMPW5SB MA Modulator DMPW5SB RN RDEA119/BAY 869766: a potent, selective, allosteric inhibitor of MEK1/2 for the treatment of cancer.Cancer Res.2009 Sep 1;69(17):6839-47. DMPW5SB RU https://www.ncbi.nlm.nih.gov/pubmed/19706763 DMPW5SB DI DMPW5SB DMPW5SB DN Bay 86-9766 DMPW5SB MI DEGTFWK DMPW5SB MN Mephenytoin 4-hydroxylase (CYP2C19) DMPW5SB MT DME DMPW5SB MA Metabolism DMPW5SB RN Multicenter phase I trial of the mitogen-activated protein kinase 1/2 inhibitor BAY 86-9766 in patients with advanced cancer. Clin Cancer Res. 2013 Mar 1;19(5):1232-43. DMPW5SB RU https://www.ncbi.nlm.nih.gov/pubmed/?term=23434733 DM09M3H DI DM09M3H DM09M3H DN BAY 94-9027 DM09M3H MI TT1290U DM09M3H MN Coagulation factor VIII (F8) DM09M3H MT DTT DM09M3H MA Modulator DM09M3H RN Phase I study of BAY 94-9027, a PEGylated B-domain-deleted recombinant factor VIII with an extended half-life, in subjects with hemophilia A. J Thromb Haemost. 2014 Apr;12(4):488-96. DM09M3H RU https://pubmed.ncbi.nlm.nih.gov/24843882 DMWYPZF DI DMWYPZF DMWYPZF DN BAY-35-3377 DMWYPZF MI TTN6J5F DMWYPZF MN Bacterial DNA gyrase (Bact gyrase) DMWYPZF MT DTT DMWYPZF MA Inhibitor DMWYPZF RN Antibiotics in the clinical pipeline in 2013. J Antibiot (Tokyo). 2013 Oct;66(10):571-91. DMWYPZF RU https://pubmed.ncbi.nlm.nih.gov/24002361 DMQG7ZM DI DMQG7ZM DMQG7ZM DN Belagenpumatucel-L DMQG7ZM MI TTI0KH6 DMQG7ZM MN TGF beta-2 messenger RNA (TGFB2 mRNA) DMQG7ZM MT DTT DMQG7ZM RN National Cancer Institute Drug Dictionary (drug id 590662). DMQG7ZM RU http://www.cancer.gov/publications/dictionaries/cancer-drug?cdrid=590662 DM71CK8 DI DM71CK8 DM71CK8 DN Beloranib DM71CK8 MI TTZL0OI DM71CK8 MN Methionine aminopeptidase 2 (METAP2) DM71CK8 MT DTT DM71CK8 MA Inhibitor DM71CK8 RN 2011 Pipeline of Zafgen. DM71CK8 RU http://www.zafgen.com/approach-pipeline.html DMLU8NX DI DMLU8NX DMLU8NX DN Benserazide DMLU8NX MI TTN451K DMLU8NX MN Aromatic-L-amino-acid decarboxylase (DDC) DMLU8NX MT DTT DMLU8NX MA Inhibitor DMLU8NX RN Catechol-O-methyltransferase inhibitors in the management of Parkinson's disease. Semin Neurol. 2001;21(1):15-22. DMLU8NX RU https://pubmed.ncbi.nlm.nih.gov/11346021 DMS9503 DI DMS9503 DMS9503 DN Benzylpenicillin DMS9503 MI TTTKCMH DMS9503 MN Bacterial Penicillin binding protein 1 (Bact pbp) DMS9503 MT DTT DMS9503 MA Binder DMS9503 RN Overexpression, purification and biochemical characterization of a class A high-molecular-mass penicillin-binding protein (PBP), PBP1* and its soluble derivative from Mycobacterium tuberculosis. Biochem J. 2002 Feb 1;361(Pt 3):635-9. DMS9503 RU https://pubmed.ncbi.nlm.nih.gov/11802794 DMS9503 DI DMS9503 DMS9503 DN Benzylpenicillin DMS9503 MI TT85JMW DMS9503 MN Bacterial Penicillin binding protein 3 (Bact mrcA) DMS9503 MT DTT DMS9503 MA Binder DMS9503 RN Association of amino acid substitutions in penicillin-binding protein 3 with beta-lactam resistance in beta-lactamase-negative ampicillin-resistant Haemophilus influenzae. Antimicrob Agents Chemother. 2001 Jun;45(6):1693-9. DMS9503 RU https://pubmed.ncbi.nlm.nih.gov/11353613 DMS9503 DI DMS9503 DMS9503 DN Benzylpenicillin DMS9503 MI DEV0KWQ DMS9503 MN Beta-lactamase (blaB) DMS9503 MT DME DMS9503 MA Metabolism DMS9503 RN Antimicrobial drugs used in the management of anaerobic infections in children. Drugs. 1983 Dec;26(6):520-9. DMS9503 RU https://pubmed.ncbi.nlm.nih.gov/6360636 DMS9503 DI DMS9503 DMS9503 DN Benzylpenicillin DMS9503 MI DET9I1W DMS9503 MN Beta-lactamase (blaB) DMS9503 MT DME DMS9503 MA Metabolism DMS9503 RN Purification and characterization of a new beta-lactamase from Bacteroides uniformis. Antimicrob Agents Chemother. 1995 Jul;39(7):1458-61. DMS9503 RU https://pubmed.ncbi.nlm.nih.gov/7492085 DMS9503 DI DMS9503 DMS9503 DN Benzylpenicillin DMS9503 MI DENJ2SQ DMS9503 MN Beta-lactamase (blaB) DMS9503 MT DME DMS9503 MA Metabolism DMS9503 RN Antimicrobial drugs used in the management of anaerobic infections in children. Drugs. 1983 Dec;26(6):520-9. DMS9503 RU https://pubmed.ncbi.nlm.nih.gov/6360636 DMS9503 DI DMS9503 DMS9503 DN Benzylpenicillin DMS9503 MI DESIWFO DMS9503 MN Beta-lactamase (blaB) DMS9503 MT DME DMS9503 MA Metabolism DMS9503 RN EBR-1, a novel Ambler subclass B1 beta-lactamase from Empedobacter brevis. Antimicrob Agents Chemother. 2002 Oct;46(10):3223-7. DMS9503 RU https://pubmed.ncbi.nlm.nih.gov/12234848 DMS9503 DI DMS9503 DMS9503 DN Benzylpenicillin DMS9503 MI DEQX0DG DMS9503 MN Beta-lactamase (blaB) DMS9503 MT DME DMS9503 MA Metabolism DMS9503 RN beta-lactamase production and antimicrobial susceptibility of oral heterogeneous Fusobacterium nucleatum populations in young children. Antimicrob Agents Chemother. 1999 May;43(5):1270-3. DMS9503 RU https://pubmed.ncbi.nlm.nih.gov/10223950 DMS9503 DI DMS9503 DMS9503 DN Benzylpenicillin DMS9503 MI DE37FJH DMS9503 MN Beta-lactamase (blaB) DMS9503 MT DME DMS9503 MA Metabolism DMS9503 RN Antimicrobial drugs used in the management of anaerobic infections in children. Drugs. 1983 Dec;26(6):520-9. DMS9503 RU https://pubmed.ncbi.nlm.nih.gov/6360636 DMS9503 DI DMS9503 DMS9503 DN Benzylpenicillin DMS9503 MI DEAILCM DMS9503 MN Beta-lactamase (blaB) DMS9503 MT DME DMS9503 MA Metabolism DMS9503 RN Beta-lactamase production in Prevotella intermedia, Prevotella nigrescens, and Prevotella pallens genotypes and in vitro susceptibilities to selected antimicrobial agents. Antimicrob Agents Chemother. 1999 Oct;43(10):2383-8. DMS9503 RU https://pubmed.ncbi.nlm.nih.gov/10508011 DMS9503 DI DMS9503 DMS9503 DN Benzylpenicillin DMS9503 MI DERPJ4F DMS9503 MN Beta-lactamase (blaB) DMS9503 MT DME DMS9503 MA Metabolism DMS9503 RN Characterization of the penA and penR genes of Burkholderia cepacia 249 which encode the chromosomal class A penicillinase and its LysR-type transcriptional regulator. Antimicrob Agents Chemother. 1997 Nov;41(11):2399-405. DMS9503 RU https://pubmed.ncbi.nlm.nih.gov/9371340 DMS9503 DI DMS9503 DMS9503 DN Benzylpenicillin DMS9503 MI DEBAZ7H DMS9503 MN Beta-lactamase (blaB) DMS9503 MT DME DMS9503 MA Metabolism DMS9503 RN Beta-lactamase production in Prevotella intermedia, Prevotella nigrescens, and Prevotella pallens genotypes and in vitro susceptibilities to selected antimicrobial agents. Antimicrob Agents Chemother. 1999 Oct;43(10):2383-8. DMS9503 RU https://pubmed.ncbi.nlm.nih.gov/10508011 DMS9503 DI DMS9503 DMS9503 DN Benzylpenicillin DMS9503 MI DEA5OYT DMS9503 MN Beta-lactamase (blaB) DMS9503 MT DME DMS9503 MA Metabolism DMS9503 RN Genetic and biochemical characterization of CGB-1, an Ambler class B carbapenem-hydrolyzing beta-lactamase from Chryseobacterium gleum. Antimicrob Agents Chemother. 2002 Sep;46(9):2791-6. DMS9503 RU https://pubmed.ncbi.nlm.nih.gov/12183230 DMS9503 DI DMS9503 DMS9503 DN Benzylpenicillin DMS9503 MI DEIU0XN DMS9503 MN N-acylhomoserine lactone acylase (lacA) DMS9503 MT DME DMS9503 MA Metabolism DMS9503 RN A novel quorum-quenching N-acylhomoserine lactone acylase from Acidovorax sp. strain MR-S7 mediates antibiotic resistance. Appl Environ Microbiol. 2017 Jun 16;83(13). pii: e00080-17. DMS9503 RU https://pubmed.ncbi.nlm.nih.gov/28455333 DMS9503 DI DMS9503 DMS9503 DN Benzylpenicillin DMS9503 MI DTVP67E DMS9503 MN Organic anion transporter 3 (SLC22A8) DMS9503 MT DTP DMS9503 MA Substrate DMS9503 RN Prediction of the overall renal tubular secretion and hepatic clearance of anionic drugs and a renal drug-drug interaction involving organic anion transporter 3 in humans by in vitro uptake experiments. Drug Metab Dispos. 2011 Jun;39(6):1031-8. DMS9503 RU http://www.ncbi.nlm.nih.gov/pubmed/21383204 DMS9503 DI DMS9503 DMS9503 DN Benzylpenicillin DMS9503 MI DT3D8F0 DMS9503 MN Organic anion transporting polypeptide 1B1 (SLCO1B1) DMS9503 MT DTP DMS9503 MA Substrate DMS9503 RN Organic anion transporting polypeptide 1B1: a genetically polymorphic transporter of major importance for hepatic drug uptake. Pharmacol Rev. 2011 Mar;63(1):157-81. DMS9503 RU http://www.ncbi.nlm.nih.gov/pubmed/21245207 DMS9503 DI DMS9503 DMS9503 DN Benzylpenicillin DMS9503 MI DT9C1TS DMS9503 MN Organic anion transporting polypeptide 1B3 (SLCO1B3) DMS9503 MT DTP DMS9503 MA Substrate DMS9503 RN Molecular characterization and inhibition of amanitin uptake into human hepatocytes. Toxicol Sci. 2006 May;91(1):140-9. DMS9503 RU http://www.ncbi.nlm.nih.gov/pubmed/16495352 DMS9503 DI DMS9503 DMS9503 DN Benzylpenicillin DMS9503 MI DTPFTEQ DMS9503 MN Organic anion transporting polypeptide 2B1 (SLCO2B1) DMS9503 MT DTP DMS9503 MA Substrate DMS9503 RN Molecular identification and characterization of novel members of the human organic anion transporter (OATP) family. Biochem Biophys Res Commun. 2000 Jun 24;273(1):251-60. DMS9503 RU http://www.ncbi.nlm.nih.gov/pubmed/10873595 DMS9503 DI DMS9503 DMS9503 DN Benzylpenicillin DMS9503 MI DTVNRXW DMS9503 MN Organic anion transporting polypeptide 3A1 (SLCO3A1) DMS9503 MT DTP DMS9503 MA Substrate DMS9503 RN Molecular identification and characterization of novel members of the human organic anion transporter (OATP) family. Biochem Biophys Res Commun. 2000 Jun 24;273(1):251-60. DMS9503 RU http://www.ncbi.nlm.nih.gov/pubmed/10873595 DMS9503 DI DMS9503 DMS9503 DN Benzylpenicillin DMS9503 MI DT8H2IC DMS9503 MN Organic anion transporting polypeptide 4A1 (SLCO4A1) DMS9503 MT DTP DMS9503 MA Substrate DMS9503 RN Molecular identification and characterization of novel members of the human organic anion transporter (OATP) family. Biochem Biophys Res Commun. 2000 Jun 24;273(1):251-60. DMS9503 RU http://www.ncbi.nlm.nih.gov/pubmed/10873595 DMS9503 DI DMS9503 DMS9503 DN Benzylpenicillin DMS9503 MI DT9G7XN DMS9503 MN Peptide transporter 1 (SLC15A1) DMS9503 MT DTP DMS9503 MA Substrate DMS9503 RN Drug transport in corneal epithelium and blood-retina barrier: emerging role of transporters in ocular pharmacokinetics. Adv Drug Deliv Rev. 2006 Nov 15;58(11):1136-63. DMS9503 RU https://doi.org/10.1016/j.addr.2006.07.024 DM6RWBN DI DM6RWBN DM6RWBN DN Beperminogene perplasmid DM6RWBN MI TTNDSF4 DM6RWBN MN Proto-oncogene c-Met (MET) DM6RWBN MT DTT DM6RWBN MA Modulator DM6RWBN RN Beperminogene perplasmid for the treatment of critical limb ischemia. Expert Rev Cardiovasc Ther. 2014 Oct;12(10):1145-56. DM6RWBN RU https://pubmed.ncbi.nlm.nih.gov/25190335 DMLVNTA DI DMLVNTA DMLVNTA DN Besipirdine DMLVNTA MI TTNGILX DMLVNTA MN Adrenergic receptor alpha-1A (ADRA1A) DMLVNTA MT DTT DMLVNTA MA Antagonist DMLVNTA RN Alpha-Adrenergic activity and cardiovascular effects of besipirdine HCl (HP 749) and metabolite P7480 in vitro and in the conscious rat and dog. J Pharmacol Exp Ther. 1997 Apr;281(1):337-46. DMLVNTA RU https://pubmed.ncbi.nlm.nih.gov/9103515 DM0MI81 DI DM0MI81 DM0MI81 DN Bevacizumab + Erlotinib DM0MI81 MI TTGKNB4 DM0MI81 MN Epidermal growth factor receptor (EGFR) DM0MI81 MT DTT DM0MI81 MA Inhibitor DM0MI81 RN Clinical pipeline report, company report or official report of Roche (2009). DM0MI81 RU http://www.roche.com/research_and_development/pipeline/roche_pharma_pipeline.htm DM0MI81 DI DM0MI81 DM0MI81 DN Bevacizumab + Erlotinib DM0MI81 MI TTOHSBA DM0MI81 MN Vascular endothelial growth factor A (VEGFA) DM0MI81 MT DTT DM0MI81 MA Inhibitor DM0MI81 RN Clinical pipeline report, company report or official report of Roche (2009). DM0MI81 RU http://www.roche.com/research_and_development/pipeline/roche_pharma_pipeline.htm DM9EXGI DI DM9EXGI DM9EXGI DN Bevacizumab + Rituximab DM9EXGI MI TTUE541 DM9EXGI MN Leukocyte surface antigen Leu-16 (CD20) DM9EXGI MT DTT DM9EXGI RN Clinical pipeline report, company report or official report of Roche (2009). DM9EXGI RU http://www.roche.com/research_and_development/pipeline/roche_pharma_pipeline.htm DM9EXGI DI DM9EXGI DM9EXGI DN Bevacizumab + Rituximab DM9EXGI MI TTOHSBA DM9EXGI MN Vascular endothelial growth factor A (VEGFA) DM9EXGI MT DTT DM9EXGI MA Inhibitor DM9EXGI RN Clinical pipeline report, company report or official report of Roche (2009). DM9EXGI RU http://www.roche.com/research_and_development/pipeline/roche_pharma_pipeline.htm DM9CEI5 DI DM9CEI5 DM9CEI5 DN Bevacizumab + Trastuzumab DM9CEI5 MI TT6EO5L DM9CEI5 MN Erbb2 tyrosine kinase receptor (HER2) DM9CEI5 MT DTT DM9CEI5 RN Clinical pipeline report, company report or official report of Roche (2009). DM9CEI5 RU http://www.roche.com/research_and_development/pipeline/roche_pharma_pipeline.htm DM9CEI5 DI DM9CEI5 DM9CEI5 DN Bevacizumab + Trastuzumab DM9CEI5 MI TTS4UGC DM9CEI5 MN Farnesoid X-activated receptor (FXR) DM9CEI5 MT DTT DM9CEI5 MA Antagonist DM9CEI5 RN Lithocholic acid decreases expression of bile salt export pump through farnesoid X receptor antagonist activity. J Biol Chem. 2002 Aug 30;277(35):31441-7. DM9CEI5 RU https://pubmed.ncbi.nlm.nih.gov/12052824 DM9CEI5 DI DM9CEI5 DM9CEI5 DN Bevacizumab + Trastuzumab DM9CEI5 MI TTOHSBA DM9CEI5 MN Vascular endothelial growth factor A (VEGFA) DM9CEI5 MT DTT DM9CEI5 MA Inhibitor DM9CEI5 RN Clinical pipeline report, company report or official report of Roche (2009). DM9CEI5 RU http://www.roche.com/research_and_development/pipeline/roche_pharma_pipeline.htm DMK56G0 DI DMK56G0 DMK56G0 DN Bexagliflozin DMK56G0 MI TTF8JAT DMK56G0 MN SLC5A2 messenger RNA (SLC5A2 mRNA) DMK56G0 MT DTT DMK56G0 MA Inhibitor DMK56G0 RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMK56G0 RU http://phrma-docs.phrma.org/files/dmfile/mid-diabetes-drug-list.pdf DM7NJYC DI DM7NJYC DM7NJYC DN BGB-A317 DM7NJYC MI TTNBFWK DM7NJYC MN Programmed cell death protein 1 (PD-1) DM7NJYC MT DTT DM7NJYC MA Inhibitor DM7NJYC RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DM7NJYC RU http://phrma-docs.phrma.org/files/dmfile/MID_Immuno-Oncology-2017_Drug-List1.pdf DMNKBEC DI DMNKBEC DMNKBEC DN BGJ398 DMNKBEC MI TT0LF7H DMNKBEC MN Fibroblast growth factor receptor (FGFR) DMNKBEC MT DTT DMNKBEC MA Inhibitor DMNKBEC RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMNKBEC RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DMNKBEC DI DMNKBEC DMNKBEC DN BGJ398 DMNKBEC MI TTRLW2X DMNKBEC MN Fibroblast growth factor receptor 1 (FGFR1) DMNKBEC MT DTT DMNKBEC MA Modulator DMNKBEC RN Pharmacological inhibition of fibroblast growth factor (FGF) receptor signaling ameliorates FGF23-mediated hypophosphatemic rickets. J Bone Miner Res. 2013 Apr;28(4):899-911. DMNKBEC RU https://pubmed.ncbi.nlm.nih.gov/23129509 DM3MXT8 DI DM3MXT8 DM3MXT8 DN BI 201335 DM3MXT8 MI TT5FNQT DM3MXT8 MN Human immunodeficiency virus Protease (HIV PR) DM3MXT8 MT DTT DM3MXT8 MA Inhibitor DM3MXT8 RN 2011 Pipeline of Boehringer Ingelheim Pharma. DM3MXT8 RU http://www.boehringer-ingelheim.com/ DMH3XDR DI DMH3XDR DMH3XDR DN BI 425809 DMH3XDR MI TTHJTF7 DMH3XDR MN Glycine transporter GlyT-1 (SLC6A9) DMH3XDR MT DTT DMH3XDR MA Inhibitor DMH3XDR RN Efficacy and safety of the novel glycine transporter inhibitor BI 425809 once daily in patients with schizophrenia: a double-blind, randomised, placebo-controlled phase 2 study. Lancet Psychiatry. 2021 Mar;8(3):191-201. DMH3XDR RU https://pubmed.ncbi.nlm.nih.gov/33610228 DMBH4FL DI DMBH4FL DMBH4FL DN BI 655066 DMBH4FL MI TTC1GLB DMBH4FL MN Interleukin-23 (IL23) DMBH4FL MT DTT DMBH4FL RN Anti-IL-23A mAb BI 655066 for treatment of moderate-to-severe psoriasis: Safety, efficacy, pharmacokinetics, and biomarker results of a single-rising-dose, randomized, double-blind, placebo-controlled trial. J Allergy Clin Immunol. 2015 Jul;136(1):116-124.e7. DMBH4FL RU https://pubmed.ncbi.nlm.nih.gov/25769911 DM42GP9 DI DM42GP9 DM42GP9 DN Bicifadine DM42GP9 MI DEJGDUW DM42GP9 MN Cytochrome P450 1A2 (CYP1A2) DM42GP9 MT DME DM42GP9 MA Metabolism DM42GP9 RN In vitro metabolism of the analgesic bicifadine in the mouse, rat, monkey, and human. Drug Metab Dispos. 2007 Dec;35(12):2232-41. DM42GP9 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=17881661 DM42GP9 DI DM42GP9 DM42GP9 DN Bicifadine DM42GP9 MI DECB0K3 DM42GP9 MN Cytochrome P450 2D6 (CYP2D6) DM42GP9 MT DME DM42GP9 MA Metabolism DM42GP9 RN In vitro metabolism of the analgesic bicifadine in the mouse, rat, monkey, and human. Drug Metab Dispos. 2007 Dec;35(12):2232-41. DM42GP9 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=17881661 DM42GP9 DI DM42GP9 DM42GP9 DN Bicifadine DM42GP9 MI TTAWNKZ DM42GP9 MN Norepinephrine transporter (NET) DM42GP9 MT DTT DM42GP9 MA Modulator DM42GP9 RN Preclinical Evaluation of the Abuse Potential of the Analgesic Bicifadine DM42GP9 RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3202431 DM42GP9 DI DM42GP9 DM42GP9 DN Bicifadine DM42GP9 MI TT3ROYC DM42GP9 MN Serotonin transporter (SERT) DM42GP9 MT DTT DM42GP9 MA Modulator DM42GP9 RN Preclinical Evaluation of the Abuse Potential of the Analgesic Bicifadine DM42GP9 RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3202431 DM57B9J DI DM57B9J DM57B9J DN Biferonex DM57B9J MI TT4TZ8J DM57B9J MN Interferon-beta (IFNB1) DM57B9J MT DTT DM57B9J MA Modulator DM57B9J RN Improving compliance with interferon-beta therapy in patients with multiple sclerosis. CNS Drugs. 2009;23(6):453-62. DM57B9J RU https://pubmed.ncbi.nlm.nih.gov/19480465 DM51JW4 DI DM51JW4 DM51JW4 DN BIIB037 DM51JW4 MI TTE4KHA DM51JW4 MN Amyloid beta A4 protein (APP) DM51JW4 MT DTT DM51JW4 MA Modulator DM51JW4 RN Passive anti-amyloid immunotherapy in Alzheimer's disease: What are the most promising targets . Immun Ageing. 2013; 10: 18. DM51JW4 RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3681567/ DM0AEDT DI DM0AEDT DM0AEDT DN BIIB067 DM0AEDT MI TT6RVLG DM0AEDT MN Superoxide dismutase Cu-Zn (SOD Cu-Zn) DM0AEDT MT DTT DM0AEDT MA Inhibitor DM0AEDT RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DM0AEDT RU http://phrma-docs.phrma.org/files/dmfile/MID_Neurological-Disorders-Drug-List_2018.pdf DMR9TF1 DI DMR9TF1 DMR9TF1 DN Bimekizumab DMR9TF1 MI TT2B6PS DMR9TF1 MN Cytokine ML-1 (IL17F) DMR9TF1 MT DTT DMR9TF1 RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMR9TF1 RU http://phrma-docs.phrma.org/files/dmfile/MID_Skin_Diseases_2018_9_FINAL.pdf DMR9TF1 DI DMR9TF1 DMR9TF1 DN Bimekizumab DMR9TF1 MI TTG0MT6 DMR9TF1 MN Interleukin-17 (IL17) DMR9TF1 MT DTT DMR9TF1 RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMR9TF1 RU http://phrma-docs.phrma.org/files/dmfile/MID_Skin_Diseases_2018_9_FINAL.pdf DMS2GA1 DI DMS2GA1 DMS2GA1 DN Bindarit DMS2GA1 MI TTNAY0P DMS2GA1 MN Monocyte chemotactic and activating factor (CCL2) DMS2GA1 MT DTT DMS2GA1 MA Inhibitor DMS2GA1 RN Bindarit: an anti-inflammatory small molecule that modulates the NF B pathway. Cell Cycle. 2012 Jan 1;11(1):159-69. DMS2GA1 RU https://pubmed.ncbi.nlm.nih.gov/22189654 DMVHF8G DI DMVHF8G DMVHF8G DN Binodenoson DMVHF8G MI TTM2AOE DMVHF8G MN Adenosine A2a receptor (ADORA2A) DMVHF8G MT DTT DMVHF8G MA Agonist DMVHF8G RN Coronary circulation responses to binodenoson, a selective adenosine A2A receptor agonist. Am J Cardiol. 2007 Jun 1;99(11):1507-12. DMVHF8G RU https://pubmed.ncbi.nlm.nih.gov/17531571 DME76AP DI DME76AP DME76AP DN Bis(olanzapine) pamoate monohydrate DME76AP MI TTYSN63 DME76AP MN 5-HT 2 receptor (5HT2R) DME76AP MT DTT DME76AP MA Modulator DME76AP RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015 DME76AP RU https://www.accessdata.fda.gov/scripts/cder/drugsatfda/ DME76AP DI DME76AP DME76AP DN Bis(olanzapine) pamoate monohydrate DME76AP MI TTEX248 DME76AP MN Dopamine D2 receptor (D2R) DME76AP MT DTT DME76AP MA Modulator DME76AP RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015 DME76AP RU https://www.accessdata.fda.gov/scripts/cder/drugsatfda/ DMW34B1 DI DMW34B1 DMW34B1 DN BL-8040 DMW34B1 MI TTBID49 DMW34B1 MN C-X-C chemokine receptor type 4 (CXCR4) DMW34B1 MT DTT DMW34B1 MA Antagonist DMW34B1 RN The CXCR4 Antagonist BL-8040 Efficiently Induces Apoptosis and Inhibits The Survival Of AML Cells. November 15, 2013; Blood: 122 (21). DMW34B1 RU http://www.bloodjournal.org/content/122/21/3939?sso-checked=true DM7V9LH DI DM7V9LH DM7V9LH DN Blisibimod DM7V9LH MI TTWMIDN DM7V9LH MN B-cell-activating factor (TNFSF13B) DM7V9LH MT DTT DM7V9LH MA Inhibitor DM7V9LH RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DM7V9LH RU http://phrma-docs.phrma.org/files/dmfile/medicines-in-development-drug-list-autoimmune-diseases.pdf DM36C17 DI DM36C17 DM36C17 DN Blonanserin DM36C17 MI TTJQOD7 DM36C17 MN 5-HT 2A receptor (HTR2A) DM36C17 MT DTT DM36C17 MA Antagonist DM36C17 RN The pipeline and future of drug development in schizophrenia. Mol Psychiatry. 2007 Oct;12(10):904-22. DM36C17 RU https://pubmed.ncbi.nlm.nih.gov/17667958 DM36C17 DI DM36C17 DM36C17 DN Blonanserin DM36C17 MI DE4LYSA DM36C17 MN Cytochrome P450 3A4 (CYP3A4) DM36C17 MT DME DM36C17 MA Metabolism DM36C17 RN Profile of blonanserin for the treatment of schizophrenia. Neuropsychiatr Dis Treat. 2013;9:587-94. DM36C17 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=23766647 DM36C17 DI DM36C17 DM36C17 DN Blonanserin DM36C17 MI TTEX248 DM36C17 MN Dopamine D2 receptor (D2R) DM36C17 MT DTT DM36C17 MA Antagonist DM36C17 RN The pipeline and future of drug development in schizophrenia. Mol Psychiatry. 2007 Oct;12(10):904-22. DM36C17 RU https://pubmed.ncbi.nlm.nih.gov/17667958 DMBXR23 DI DMBXR23 DMBXR23 DN BMN-110 DMBXR23 MI TTT9YPO DMBXR23 MN N-acetylgalactosamine 6 sulfatase (GALNS) DMBXR23 MT DTT DMBXR23 MA Modulator DMBXR23 RN Efficacy and safety of enzyme replacement therapy with BMN 110 (elosulfase alfa) for Morquio A syndrome (mucopolysaccharidosis IVA): a phase 3 randomised placebo-controlled study. J Inherit Metab Dis. 2014 Nov;37(6):979-90. DMBXR23 RU https://pubmed.ncbi.nlm.nih.gov/24810369 DMM9XL2 DI DMM9XL2 DMM9XL2 DN BMN-111 DMM9XL2 MI TTRK0B9 DMM9XL2 MN C-type natriuretic peptide (NPPC) DMM9XL2 MT DTT DMM9XL2 MA Modulator DMM9XL2 RN Clinical pipeline report, company report or official report of Biomarin. DMM9XL2 RU https://www.bmrn.com/pipeline/clinical-trials/achondroplasia.php DM94Y6O DI DM94Y6O DM94Y6O DN BMN-701 DM94Y6O MI TTLPC70 DM94Y6O MN Lysosomal alpha-glucosidase (GAA) DM94Y6O MT DTT DM94Y6O MA Modulator DM94Y6O RN Clinical pipeline report, company report or official report of BioMarin Pharma. DM94Y6O RU https://www.bmrn.com/pipeline/igf2-gaa-for-pompe-disease.php DMDAN8H DI DMDAN8H DMDAN8H DN BMS-582664 DMDAN8H MI TTST7KB DMDAN8H MN Fibroblast growth factor receptor 3 (FGFR3) DMDAN8H MT DTT DMDAN8H MA Inhibitor DMDAN8H RN A comparison of physicochemical property profiles of marketed oral drugs and orally bioavailable anti-cancer protein kinase inhibitors in clinical development. Curr Top Med Chem. 2007;7(14):1408-22. DMDAN8H RU https://pubmed.ncbi.nlm.nih.gov/17692029 DMAR1YS DI DMAR1YS DMAR1YS DN BMS-986165 DMAR1YS MI TTBYWP2 DMAR1YS MN TYK2 tyrosine kinase (TYK2) DMAR1YS MT DTT DMAR1YS MA Inhibitor DMAR1YS RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMAR1YS RU http://phrma-docs.phrma.org/files/dmfile/MID_Skin_Diseases_2018_9_FINAL.pdf DM3MAYQ DI DM3MAYQ DM3MAYQ DN BMS-986205 DM3MAYQ MI TTZJYKH DM3MAYQ MN Indoleamine 2,3-dioxygenase 1 (IDO1) DM3MAYQ MT DTT DM3MAYQ MA Inhibitor DM3MAYQ RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DM3MAYQ RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DM2OBNW DI DM2OBNW DM2OBNW DN Bococizumab DM2OBNW MI TTBRG7E DM2OBNW MN Proprotein convertase subtilisin/kexin type 9 (PCSK9) DM2OBNW MT DTT DM2OBNW RN The dyslipidaemia market. Nat Rev Drug Discov. 2014 Nov;13(11):807-8. DM2OBNW RU https://pubmed.ncbi.nlm.nih.gov/25323928 DM6KRLW DI DM6KRLW DM6KRLW DN BQ788 DM6KRLW MI TT3ZTGU DM6KRLW MN Endothelin B receptor (EDNRB) DM6KRLW MT DTT DM6KRLW MA Antagonist DM6KRLW RN BQ788, an endothelin ET(B) receptor antagonist, attenuates stab wound injury-induced reactive astrocytes in rat brain. Glia. 1999 May;26(3):268-71. DM6KRLW RU https://pubmed.ncbi.nlm.nih.gov/10340767 DM942HP DI DM942HP DM942HP DN Brivanib DM942HP MI TTUTJGQ DM942HP MN Vascular endothelial growth factor receptor 2 (KDR) DM942HP MT DTT DM942HP MA Modulator DM942HP RN Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41. DM942HP RU https://www.ncbi.nlm.nih.gov/pubmed/15950434 DMM0VO3 DI DMM0VO3 DMM0VO3 DN BSI-201 DMM0VO3 MI TTEBCY8 DMM0VO3 MN Poly [ADP-ribose] polymerase (PARP) DMM0VO3 MT DTT DMM0VO3 MA Modulator DMM0VO3 RN Failure of iniparib to inhibit poly(ADP-Ribose) polymerase in vitro. Clin Cancer Res. 2012 Mar 15;18(6):1655-62. DMM0VO3 RU https://pubmed.ncbi.nlm.nih.gov/22291137 DM50SNX DI DM50SNX DM50SNX DN Bucelipase alfa DM50SNX MI TTTRNQW DM50SNX MN Bile-salt-activated lipase (CEL) DM50SNX MT DTT DM50SNX MA Modulator DM50SNX RN ClinicalTrials.gov (NCT00743483) Efficacy of Bucelipase Alfa (BSSL) in Patients With Cystic Fibrosis and Pancreatic Insufficiency. U.S. National Institutes of Health. DM50SNX RU https://clinicaltrials.gov/ct2/show/NCT00743483 DM1WEHC DI DM1WEHC DM1WEHC DN Buparlisib DM1WEHC MI TTEUNMR DM1WEHC MN PI3-kinase alpha (PIK3CA) DM1WEHC MT DTT DM1WEHC MA Inhibitor DM1WEHC RN Targeting the phosphoinositide 3-kinase pathway in cancer. Nat Rev Drug Discov. 2009 Aug;8(8):627-44. DM1WEHC RU https://pubmed.ncbi.nlm.nih.gov/19644473 DM1WEHC DI DM1WEHC DM1WEHC DN Buparlisib DM1WEHC MI TTTHBCA DM1WEHC MN PI3-kinase beta (PIK3CB) DM1WEHC MT DTT DM1WEHC MA Inhibitor DM1WEHC RN Targeting the phosphoinositide 3-kinase pathway in cancer. Nat Rev Drug Discov. 2009 Aug;8(8):627-44. DM1WEHC RU https://pubmed.ncbi.nlm.nih.gov/19644473 DM1WEHC DI DM1WEHC DM1WEHC DN Buparlisib DM1WEHC MI TTGBPJE DM1WEHC MN PI3-kinase delta (PIK3CD) DM1WEHC MT DTT DM1WEHC MA Inhibitor DM1WEHC RN Targeting the phosphoinositide 3-kinase pathway in cancer. Nat Rev Drug Discov. 2009 Aug;8(8):627-44. DM1WEHC RU https://pubmed.ncbi.nlm.nih.gov/19644473 DM1WEHC DI DM1WEHC DM1WEHC DN Buparlisib DM1WEHC MI TTHBTOP DM1WEHC MN PI3-kinase gamma (PIK3CG) DM1WEHC MT DTT DM1WEHC MA Inhibitor DM1WEHC RN Targeting the phosphoinositide 3-kinase pathway in cancer. Nat Rev Drug Discov. 2009 Aug;8(8):627-44. DM1WEHC RU https://pubmed.ncbi.nlm.nih.gov/19644473 DMAR9ND DI DMAR9ND DMAR9ND DN Bupropion+Naltrexone DMAR9ND MI TTVBI8W DMAR9ND MN Dopamine transporter (DAT) DMAR9ND MT DTT DMAR9ND MA Inhibitor DMAR9ND RN Anti-obesity drugs. Expert Opin Pharmacother. 2008 Jun;9(8):1339-50. DMAR9ND RU https://pubmed.ncbi.nlm.nih.gov/18473708 DMAR9ND DI DMAR9ND DMAR9ND DN Bupropion+Naltrexone DMAR9ND MI TTAWNKZ DMAR9ND MN Norepinephrine transporter (NET) DMAR9ND MT DTT DMAR9ND MA Inhibitor DMAR9ND RN Anti-obesity drugs. Expert Opin Pharmacother. 2008 Jun;9(8):1339-50. DMAR9ND RU https://pubmed.ncbi.nlm.nih.gov/18473708 DMAR9ND DI DMAR9ND DMAR9ND DN Bupropion+Naltrexone DMAR9ND MI TTN4QDT DMAR9ND MN Opioid receptor (OPR) DMAR9ND MT DTT DMAR9ND MA Antagonist DMAR9ND RN Anti-obesity drugs. Expert Opin Pharmacother. 2008 Jun;9(8):1339-50. DMAR9ND RU https://pubmed.ncbi.nlm.nih.gov/18473708 DM6RUKX DI DM6RUKX DM6RUKX DN BVT.2733 DM6RUKX MI TTN7BL9 DM6RUKX MN Corticosteroid 11-beta-dehydrogenase 1 (HSD11B1) DM6RUKX MT DTT DM6RUKX MA Inhibitor DM6RUKX RN Selective inhibition of 11 beta-hydroxysteroid dehydrogenase type 1 improves hepatic insulin sensitivity in hyperglycemic mice strains. Endocrinology. 2003 Nov;144(11):4755-62. DM6RUKX RU https://pubmed.ncbi.nlm.nih.gov/12960099 DM1ARHT DI DM1ARHT DM1ARHT DN BYM338 DM1ARHT MI TTX2DRI DM1ARHT MN Activin receptor type IIA (ACVR2A) DM1ARHT MT DTT DM1ARHT MA Inhibitor DM1ARHT RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DM1ARHT RU http://phrma-docs.phrma.org/files/dmfile/MID_Neurological-Disorders-Drug-List_2018.pdf DMPTCYB DI DMPTCYB DMPTCYB DN Cadi-05 DMPTCYB MI TTY7ZHS DMPTCYB MN Toll-like receptor 2 (TLR2) DMPTCYB MT DTT DMPTCYB RN Trial Watch: Experimental Toll-like receptor agonists for cancer therapy. Oncoimmunology. 2012 August 1; 1(5): 699-716. DMPTCYB RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3429574/ DMPTCYB DI DMPTCYB DMPTCYB DN Cadi-05 DMPTCYB MI TTISGCA DMPTCYB MN Toll-like receptor 4 (TLR4) DMPTCYB MT DTT DMPTCYB RN Trial Watch: Experimental Toll-like receptor agonists for cancer therapy. Oncoimmunology. 2012 August 1; 1(5): 699-716. DMPTCYB RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3429574/ DMPTCYB DI DMPTCYB DMPTCYB DN Cadi-05 DMPTCYB MI TTSHG0T DMPTCYB MN Toll-like receptor 9 (TLR9) DMPTCYB MT DTT DMPTCYB RN Trial Watch: Experimental Toll-like receptor agonists for cancer therapy. Oncoimmunology. 2012 August 1; 1(5): 699-716. DMPTCYB RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3429574/ DM6CHNJ DI DM6CHNJ DM6CHNJ DN Camptothecin DM6CHNJ MI DTI7UX6 DM6CHNJ MN Breast cancer resistance protein (ABCG2) DM6CHNJ MT DTP DM6CHNJ MA Substrate DM6CHNJ RN The beta-carboline alkaloid harmine inhibits BCRP and can reverse resistance to the anticancer drugs mitoxantrone and camptothecin in breast cancer cells. Phytother Res. 2010 Jan;24(1):146-9. DM6CHNJ RU https://doi.org/10.1002/ptr.2860 DM6CHNJ DI DM6CHNJ DM6CHNJ DN Camptothecin DM6CHNJ MI TTGTQHC DM6CHNJ MN DNA topoisomerase I (TOP1) DM6CHNJ MT DTT DM6CHNJ MA Modulator DM6CHNJ RN Topoisomerase I inhibitors: camptothecins and beyond. Nat Rev Cancer. 2006 Oct;6(10):789-802. DM6CHNJ RU https://pubmed.ncbi.nlm.nih.gov/16990856 DM6CHNJ DI DM6CHNJ DM6CHNJ DN Camptothecin DM6CHNJ MI DTFI42L DM6CHNJ MN Multidrug resistance-associated protein 2 (ABCC2) DM6CHNJ MT DTP DM6CHNJ MA Substrate DM6CHNJ RN Pharmacogenetics of membrane transporters: an update on current approaches. Mol Biotechnol. 2010 Feb;44(2):152-67. DM6CHNJ RU https://doi.org/10.1007/s12033-009-9220-6 DM6CHNJ DI DM6CHNJ DM6CHNJ DN Camptothecin DM6CHNJ MI DTCSGPB DM6CHNJ MN Multidrug resistance-associated protein 4 (ABCC4) DM6CHNJ MT DTP DM6CHNJ MA Substrate DM6CHNJ RN Human intestinal transporter database: QSAR modeling and virtual profiling of drug uptake, efflux and interactions. Pharm Res. 2013 Apr;30(4):996-1007. DM6CHNJ RU https://doi.org/10.1007/s11095-012-0935-x DMHJCGV DI DMHJCGV DMHJCGV DN Candoxatril DMHJCGV MI TT5TKPM DMHJCGV MN Neutral endopeptidase (MME) DMHJCGV MT DTT DMHJCGV MA Inhibitor DMHJCGV RN Neutral endopeptidase inhibitor suppresses the early phase of atrial electrical remodeling in a canine rapid atrial pacing model. Indian Pacing Electrophysiol J. 2008 Apr 1;8(2):102-13. DMHJCGV RU https://pubmed.ncbi.nlm.nih.gov/18379655 DM4FHQR DI DM4FHQR DM4FHQR DN Canfosfamide DM4FHQR MI TT40K12 DM4FHQR MN Glutathione S-transferase P (GSTP1) DM4FHQR MT DTT DM4FHQR MA Modulator DM4FHQR RN Mechanism of glutathione transferase P1-1-catalyzed activation of the prodrug canfosfamide (TLK286, TELCYTA). Biochemistry. 2013 Nov 12;52(45):8069-78. DM4FHQR RU https://pubmed.ncbi.nlm.nih.gov/24066958 DMMZDJ6 DI DMMZDJ6 DMMZDJ6 DN Captopril DMMZDJ6 MI TTGFNPD DMMZDJ6 MN HUMAN angiotensin-converting enzyme (ACE) DMMZDJ6 MT DTT DMMZDJ6 MA Inhibitor DMMZDJ6 RN Outcomes in Patients with COVID-19 Infection Taking ACEI/ARB. Curr Cardiol Rep. 2020 Apr 14;22(5):31. DMMZDJ6 RU https://pubmed.ncbi.nlm.nih.gov/32291526 DMUVMWZ DI DMUVMWZ DMUVMWZ DN Carebastine DMUVMWZ MI DERSX5P DMUVMWZ MN Cytochrome P450 2J2 (CYP2J2) DMUVMWZ MT DME DMUVMWZ MA Metabolism DMUVMWZ RN Characterization of ebastine, hydroxyebastine, and carebastine metabolism by human liver microsomes and expressed cytochrome P450 enzymes: major roles for CYP2J2 and CYP3A. Drug Metab Dispos. 2006 Nov;34(11):1793-7. DMUVMWZ RU https://www.ncbi.nlm.nih.gov/pubmed/?term=16896065 DMUVMWZ DI DMUVMWZ DMUVMWZ DN Carebastine DMUVMWZ MI DE4LYSA DMUVMWZ MN Cytochrome P450 3A4 (CYP3A4) DMUVMWZ MT DME DMUVMWZ MA Metabolism DMUVMWZ RN Characterization of ebastine, hydroxyebastine, and carebastine metabolism by human liver microsomes and expressed cytochrome P450 enzymes: major roles for CYP2J2 and CYP3A. Drug Metab Dispos. 2006 Nov;34(11):1793-7. DMUVMWZ RU https://www.ncbi.nlm.nih.gov/pubmed/?term=16896065 DMUVMWZ DI DMUVMWZ DMUVMWZ DN Carebastine DMUVMWZ MI TTTIBOJ DMUVMWZ MN Histamine H1 receptor (H1R) DMUVMWZ MT DTT DMUVMWZ MA Antagonist DMUVMWZ RN Emerging drugs for ocular allergy. Expert Opin Emerg Drugs. 2005 Aug;10(3):505-20. DMUVMWZ RU https://pubmed.ncbi.nlm.nih.gov/16083326 DM4Y1SP DI DM4Y1SP DM4Y1SP DN Carisbamate DM4Y1SP MI TTRK8B9 DM4Y1SP MN Sodium channel unspecific (NaC) DM4Y1SP MT DTT DM4Y1SP MA Blocker DM4Y1SP RN Progress report on new antiepileptic drugs: a summary of the Ninth Eilat Conference (EILAT IX). Epilepsy Res. 2009 Jan;83(1):1-43. DM4Y1SP RU https://pubmed.ncbi.nlm.nih.gov/19008076 DM4Y1SP DI DM4Y1SP DM4Y1SP DN Carisbamate DM4Y1SP MI DEYGVN4 DM4Y1SP MN UDP-glucuronosyltransferase 1A1 (UGT1A1) DM4Y1SP MT DME DM4Y1SP MA Metabolism DM4Y1SP RN Carisbamate addon therapy for drugresistant partial epilepsy. The Cochrane Library. John Wiley Sons, Ltd, 2016. DM4Y1SP RU https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD012121/full DMPG4OM DI DMPG4OM DMPG4OM DN CAZ AVI DMPG4OM MI TTHI19T DMPG4OM MN Staphylococcus Beta-lactamase (Stap-coc blaZ) DMPG4OM MT DTT DMPG4OM MA Modulator DMPG4OM RN NXL104 irreversibly inhibits the -lactamase from Mycobacterium tuberculosis. Biochemistry. 2012 Jun 5;51(22):4551-7. DMPG4OM RU https://pubmed.ncbi.nlm.nih.gov/22587688 DM097UP DI DM097UP DM097UP DN CBT-1 DM097UP MI TT3OT40 DM097UP MN Multidrug resistance protein 1 (ABCB1) DM097UP MT DTT DM097UP MA Modulator DM097UP RN A pharmacodynamic study of the P-glycoprotein antagonist CBT-1 in combination with paclitaxel in solid tumors. Oncologist.2012;17(4):512. DM097UP RU https://www.ncbi.nlm.nih.gov/pubmed/22416063 DMV7WSN DI DMV7WSN DMV7WSN DN CC-25430 DMV7WSN MI DE4LYSA DMV7WSN MN Cytochrome P450 3A4 (CYP3A4) DMV7WSN MT DME DMV7WSN MA Metabolism DMV7WSN RN Integrated analysis on the physicochemical properties of dihydropyridine calcium channel blockers in grapefruit juice interactions. Curr Pharm Biotechnol. 2012 Jul;13(9):1705-17. DMV7WSN RU https://www.ncbi.nlm.nih.gov/pubmed/?term=22039822 DMTNQB0 DI DMTNQB0 DMTNQB0 DN CC-486 DMTNQB0 MI TT6S2FE DMTNQB0 MN DNA [cytosine-5]-methyltransferase 1 (DNMT1) DMTNQB0 MT DTT DMTNQB0 MA Inhibitor DMTNQB0 RN Efficacy and safety of extended dosing schedules of CC-486 (oral azacitidine) in patients with lower-risk myelodysplastic syndromes. Leukemia. 2016 Apr;30(4):889-96. DMTNQB0 RU https://pubmed.ncbi.nlm.nih.gov/26442612 DMTNQB0 DI DMTNQB0 DMTNQB0 DN CC-486 DMTNQB0 MI TTVDSZ0 DMTNQB0 MN Poly [ADP-ribose] polymerase 1 (PARP1) DMTNQB0 MT DTT DMTNQB0 MA Inhibitor DMTNQB0 RN Tricyclic benzimidazoles as potent poly(ADP-ribose) polymerase-1 inhibitors. J Med Chem. 2003 Jan 16;46(2):210-3. DMTNQB0 RU https://pubmed.ncbi.nlm.nih.gov/12519059 DM5LQHB DI DM5LQHB DM5LQHB DN CCX-168 DM5LQHB MI TTHXFA1 DM5LQHB MN C5a anaphylatoxin chemotactic receptor (C5AR1) DM5LQHB MT DTT DM5LQHB MA Antagonist DM5LQHB RN Clinical pipeline report, company report or official report of ChemoCentryx. DM5LQHB RU http://www.chemocentryx.com/pipeline/orphan-and-rare-diseases/ DMWO5ZR DI DMWO5ZR DMWO5ZR DN Cediranib DMWO5ZR MI DE4LYSA DMWO5ZR MN Cytochrome P450 3A4 (CYP3A4) DMWO5ZR MT DME DMWO5ZR MA Metabolism DMWO5ZR RN In vitro hepatic metabolism of cediranib, a potent vascular endothelial growth factor tyrosine kinase inhibitor: interspecies comparison and human enzymology. Drug Metab Dispos. 2010 Oct;38(10):1688-97. DMWO5ZR RU https://www.ncbi.nlm.nih.gov/pubmed/?term=20634336 DMWO5ZR DI DMWO5ZR DMWO5ZR DN Cediranib DMWO5ZR MI TTUTJGQ DMWO5ZR MN Vascular endothelial growth factor receptor 2 (KDR) DMWO5ZR MT DTT DMWO5ZR MA Inhibitor DMWO5ZR RN A comparison of physicochemical property profiles of marketed oral drugs and orally bioavailable anti-cancer protein kinase inhibitors in clinical development. Curr Top Med Chem. 2007;7(14):1408-22. DMWO5ZR RU https://pubmed.ncbi.nlm.nih.gov/17692029 DMLWIU4 DI DMLWIU4 DMLWIU4 DN Cefluprenam DMLWIU4 MI TTJP4SM DMLWIU4 MN Bacterial Penicillin binding protein (Bact PBP) DMLWIU4 MT DTT DMLWIU4 MA Inhibitor DMLWIU4 RN Comparison of cefepime, cefpirome, and cefaclidine binding affinities for penicillin-binding proteins in Escherichia coli K-12 and Pseudomonas aeruginosa SC8329. Antimicrob Agents Chemother. 1991 Nov;35(11):2312-7. DMLWIU4 RU https://pubmed.ncbi.nlm.nih.gov/1804003 DMM76GL DI DMM76GL DMM76GL DN Ceftobiprole DMM76GL MI TTJP4SM DMM76GL MN Bacterial Penicillin binding protein (Bact PBP) DMM76GL MT DTT DMM76GL MA Modulator DMM76GL RN Binding of ceftobiprole and comparators to the penicillin-binding proteins of Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, and ... Antimicrob Agents Chemother. 2007 Jul;51(7):2621-4. DMM76GL RU https://www.ncbi.nlm.nih.gov/pubmed/17470659 DMWLF2X DI DMWLF2X DMWLF2X DN Ceftobiprole medocaril DMWLF2X MI TTJP4SM DMWLF2X MN Bacterial Penicillin binding protein (Bact PBP) DMWLF2X MT DTT DMWLF2X MA Binder DMWLF2X RN Ceftobiprole medocaril for the treatment of community-acquired pneumonia. Expert Opin Pharmacother. 2018 Sep;19(13):1503-1509. DMWLF2X RU https://pubmed.ncbi.nlm.nih.gov/30198789 DMIGX84 DI DMIGX84 DMIGX84 DN Cethromycin DMIGX84 MI TTLFGBV DMIGX84 MN Bacterial 23S ribosomal RNA (Bact 23S rRNA) DMIGX84 MT DTT DMIGX84 MA Inhibitor DMIGX84 RN How many modes of action should an antibiotic have Curr Opin Pharmacol. 2008 Oct;8(5):564-73. DMIGX84 RU https://pubmed.ncbi.nlm.nih.gov/18621146 DMIGX84 DI DMIGX84 DMIGX84 DN Cethromycin DMIGX84 MI DEIBDNY DMIGX84 MN Cytochrome P450 3A5 (CYP3A5) DMIGX84 MT DME DMIGX84 MA Metabolism DMIGX84 RN CYP3A5 genotype has a dose-dependent effect on ABT-773 plasma levels. Clin Pharmacol Ther. 2004 Jun;75(6):516-28. DMIGX84 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=15179406 DMWAHTN DI DMWAHTN DMWAHTN DN Cetilistat DMWAHTN MI TTKYZA9 DMWAHTN MN Gastric triacylglycerol lipase (LIPF) DMWAHTN MT DTT DMWAHTN MA Modulator DMWAHTN RN Cetilistat (ATL-962), a novel lipase inhibitor: a 12-week randomized, placebo-controlled study of weight reduction in obese patients. Int J Obes (Lond). 2007 Mar;31(3):494-9. DMWAHTN RU https://pubmed.ncbi.nlm.nih.gov/16953261 DMX9K3W DI DMX9K3W DMX9K3W DN Cetraxal Otic DMX9K3W MI TTE72ID DMX9K3W MN Haemophilus influenzae DNA gyrase A (Hae-influ gyrA) DMX9K3W MT DTT DMX9K3W MA Modulator DMX9K3W RN DNA topoisomerases and their poisoning by anticancer and antibacterial drugs. Chem Biol. 2010 May 28;17(5):421-33. DMX9K3W RU https://pubmed.ncbi.nlm.nih.gov/20534341 DMX9K3W DI DMX9K3W DMX9K3W DN Cetraxal Otic DMX9K3W MI TT1WJCI DMX9K3W MN Streptococcus Topoisomerase IV A (Stre-coc parC) DMX9K3W MT DTT DMX9K3W MA Modulator DMX9K3W RN DNA topoisomerases and their poisoning by anticancer and antibacterial drugs. Chem Biol. 2010 May 28;17(5):421-33. DMX9K3W RU https://pubmed.ncbi.nlm.nih.gov/20534341 DMIKMA9 DI DMIKMA9 DMIKMA9 DN CG-100649 DMIKMA9 MI TTHQPL7 DMIKMA9 MN Carbonic anhydrase I (CA-I) DMIKMA9 MT DTT DMIKMA9 MA Inhibitor DMIKMA9 RN Understanding the Dual Inhibition of COX-2 and Carbonic Anhydrase-II by Celecoxib and CG100649 Using Density Functional Theory Calculations and other Molecular Modelling Approaches. Protein Pept Lett. 2015;22(10):903-12. DMIKMA9 RU https://pubmed.ncbi.nlm.nih.gov/26095375 DMIKMA9 DI DMIKMA9 DMIKMA9 DN CG-100649 DMIKMA9 MI TTANPDJ DMIKMA9 MN Carbonic anhydrase II (CA-II) DMIKMA9 MT DTT DMIKMA9 MA Inhibitor DMIKMA9 RN Understanding the Dual Inhibition of COX-2 and Carbonic Anhydrase-II by Celecoxib and CG100649 Using Density Functional Theory Calculations and other Molecular Modelling Approaches. Protein Pept Lett. 2015;22(10):903-12. DMIKMA9 RU https://pubmed.ncbi.nlm.nih.gov/26095375 DMIKMA9 DI DMIKMA9 DMIKMA9 DN CG-100649 DMIKMA9 MI TTVKILB DMIKMA9 MN Prostaglandin G/H synthase 2 (COX-2) DMIKMA9 MT DTT DMIKMA9 MA Inhibitor DMIKMA9 RN Pharmacokinetic, pharmacodynamic, and safety/tolerability profiles of CG100649, a novel COX-2 inhibitor: results of a phase i, randomized, multiple-dose study in healthy Korean men and women. Clin Ther. 2015 Jan 1;37(1):197-210. DMIKMA9 RU https://pubmed.ncbi.nlm.nih.gov/25097102 DM1TJXA DI DM1TJXA DM1TJXA DN Chloride DM1TJXA MI TTTSOUD DM1TJXA MN Candida Cytochrome P450 51 (Candi ERG11) DM1TJXA MT DTT DM1TJXA MA Modulator DM1TJXA RN Isavuconazonium: first global approval. Drugs. 2015 May;75(7):817-22. DM1TJXA RU https://pubmed.ncbi.nlm.nih.gov/25902926 DM1TJXA DI DM1TJXA DM1TJXA DN Chloride DM1TJXA MI DE4LYSA DM1TJXA MN Cytochrome P450 3A4 (CYP3A4) DM1TJXA MT DME DM1TJXA MA Metabolism DM1TJXA RN Metabolism of benzalkonium chlorides by human hepatic cytochromes P450. Chem Res Toxicol. 2019 Dec 16;32(12):2466-2478. DM1TJXA RU https://www.ncbi.nlm.nih.gov/pubmed/?term=31730751 DMORSFB DI DMORSFB DMORSFB DN Chloroquine DMORSFB MI TTZGK1R DMORSFB MN HUMAN glycosylation of host receptor (GHR) DMORSFB MT DTT DMORSFB MA Inhibitor DMORSFB RN Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro. Cell Res. 2020 Mar;30(3):269-271. DMORSFB RU https://pubmed.ncbi.nlm.nih.gov/32020029 DMORSFB DI DMORSFB DMORSFB DN Chloroquine DMORSFB MI TTD16BI DMORSFB MN HUMAN pH-dependent viral fusion/replication (pH-DVF/R) DMORSFB MT DTT DMORSFB MA Inhibitor DMORSFB RN Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro. Cell Res. 2020 Mar;30(3):269-271. DMORSFB RU https://pubmed.ncbi.nlm.nih.gov/32020029 DM5X7DJ DI DM5X7DJ DM5X7DJ DN Chlorpromazine DM5X7DJ MI TTAIY2U DM5X7DJ MN HUMAN clathrin-mediated endocytosis (RME) DM5X7DJ MT DTT DM5X7DJ MA Inhibitor DM5X7DJ RN Coronaviruses - drug discovery and therapeutic options. Nat Rev Drug Discov. 2016 May;15(5):327-47. DM5X7DJ RU https://pubmed.ncbi.nlm.nih.gov/26868298 DM0Q6CM DI DM0Q6CM DM0Q6CM DN CIGB-300 DM0Q6CM MI TTZ5NI7 DM0Q6CM MN Casein kinase II (CSNK2) DM0Q6CM MT DTT DM0Q6CM MA Modulator DM0Q6CM RN Synergistic interactions of the anti-casein kinase 2 CIGB-300 peptide and chemotherapeutic agents in lung and cervical preclinical cancer models. Mol Clin Oncol. 2014 Nov;2(6):935-944. DM0Q6CM RU https://pubmed.ncbi.nlm.nih.gov/25279177 DMP0NGX DI DMP0NGX DMP0NGX DN Cilansetron DMP0NGX MI TTPC4TU DMP0NGX MN 5-HT 3A receptor (HTR3A) DMP0NGX MT DTT DMP0NGX MA Modulator DMP0NGX RN Cilansetron: a new serotonergic agent for the irritable bowel syndrome with diarrhoea.Expert Opin Investig Drugs.2005 Feb;14(2):185-93. DMP0NGX RU https://www.ncbi.nlm.nih.gov/pubmed/15757394 DMEAOZ0 DI DMEAOZ0 DMEAOZ0 DN Cilengitide DMEAOZ0 MI TT69TQN DMEAOZ0 MN Integrin alpha-V/beta-3 (ITGAV/B3) DMEAOZ0 MT DTT DMEAOZ0 MA Modulator DMEAOZ0 RN The integrin antagonist cilengitide activates alphaVbeta3, disrupts VE-cadherin localization at cell junctions and enhances permeability in endothelial cells.PLoS One.2009;4(2):e4449. DMEAOZ0 RU https://www.ncbi.nlm.nih.gov/pubmed/19212436 DM1975O DI DM1975O DM1975O DN Cilnidipine DM1975O MI DE4LYSA DM1975O MN Cytochrome P450 3A4 (CYP3A4) DM1975O MT DME DM1975O MA Metabolism DM1975O RN Metabolism and metabolic inhibition of cilnidipine in human liver microsomes. Acta Pharmacol Sin. 2003 Mar;24(3):263-8. DM1975O RU https://www.ncbi.nlm.nih.gov/pubmed/?term=12617777 DM1975O DI DM1975O DM1975O DN Cilnidipine DM1975O MI TT4FDG6 DM1975O MN Voltage-gated calcium channel alpha Cav2.2 (CACNA1B) DM1975O MT DTT DM1975O MA Blocker DM1975O RN N- and L-type calcium channel antagonist improves glomerular dynamics, reverses severe nephrosclerosis, and inhibits apoptosis and proliferation in an l-NAME/SHR model. J Hypertens. 2002 May;20(5):993-1000. DM1975O RU https://pubmed.ncbi.nlm.nih.gov/12011661 DM1975O DI DM1975O DM1975O DN Cilnidipine DM1975O MI TTXHYV6 DM1975O MN Voltage-gated L-type calcium channel (L-CaC) DM1975O MT DTT DM1975O MA Blocker DM1975O RN N- and L-type calcium channel antagonist improves glomerular dynamics, reverses severe nephrosclerosis, and inhibits apoptosis and proliferation in an l-NAME/SHR model. J Hypertens. 2002 May;20(5):993-1000. DM1975O RU https://pubmed.ncbi.nlm.nih.gov/12011661 DMU2J7Y DI DMU2J7Y DMU2J7Y DN Ciltacabtagene autoleucel DMU2J7Y MI TTZ3P4W DMU2J7Y MN B-cell maturation protein (TNFRSF17) DMU2J7Y MT DTT DMU2J7Y RN ClinicalTrials.gov (NCT04181827) A Study Comparing JNJ-68284528, a CAR-T Therapy Directed Against B-cell Maturation Antigen (BCMA), Versus Pomalidomide, Bortezomib and Dexamethasone (PVd) or Daratumumab, Pomalidomide and Dexamethasone (DPd) in Participants With Relapsed and Lenalidomide-Refractory Multiple Myeloma (CARTITUDE-4). U.S. National Institutes of Health. DMU2J7Y RU https://clinicaltrials.gov/ct2/show/NCT04181827 DMEGFYD DI DMEGFYD DMEGFYD DN Cinitapride DMEGFYD MI DES5XRU DMEGFYD MN Cytochrome P450 2C8 (CYP2C8) DMEGFYD MT DME DMEGFYD MA Metabolism DMEGFYD RN The prokinetic cinitapride has no clinically relevant pharmacokinetic interaction and effect on QT during coadministration with ketoconazole. Drug Metab Dispos. 2007 Jul;35(7):1149-56. DMEGFYD RU https://www.ncbi.nlm.nih.gov/pubmed/?term=17437965 DMEGFYD DI DMEGFYD DMEGFYD DN Cinitapride DMEGFYD MI DE4LYSA DMEGFYD MN Cytochrome P450 3A4 (CYP3A4) DMEGFYD MT DME DMEGFYD MA Metabolism DMEGFYD RN The prokinetic cinitapride has no clinically relevant pharmacokinetic interaction and effect on QT during coadministration with ketoconazole. Drug Metab Dispos. 2007 Jul;35(7):1149-56. DMEGFYD RU https://www.ncbi.nlm.nih.gov/pubmed/?term=17437965 DM803GL DI DM803GL DM803GL DN CIPEMASTAT DM803GL MI TTMX39J DM803GL MN Matrix metalloproteinase-1 (MMP-1) DM803GL MT DTT DM803GL MA Modulator DM803GL RN Matrix metalloproteinase inhibition lowers mortality and brain injury in experimental pneumococcal meningitis. Infect Immun. 2014 Apr;82(4):1710-8. DM803GL RU https://pubmed.ncbi.nlm.nih.gov/24491581 DM803GL DI DM803GL DM803GL DN CIPEMASTAT DM803GL MI TTGA1IV DM803GL MN Matrix metalloproteinase-8 (MMP-8) DM803GL MT DTT DM803GL MA Modulator DM803GL RN Matrix metalloproteinase inhibition lowers mortality and brain injury in experimental pneumococcal meningitis. Infect Immun. 2014 Apr;82(4):1710-8. DM803GL RU https://pubmed.ncbi.nlm.nih.gov/24491581 DMJ9ZIY DI DMJ9ZIY DMJ9ZIY DN CK-2017357 DMJ9ZIY MI TTYUMF5 DMJ9ZIY MN Fast skeletal muscle troponin complex (TNNC2) DMJ9ZIY MT DTT DMJ9ZIY MA Modulator DMJ9ZIY RN Activation of fast skeletal muscle troponin as a potential therapeutic approach for treating neuromuscular diseases. Nat Med. 2012 Feb 19;18(3):452-5. DMJ9ZIY RU https://pubmed.ncbi.nlm.nih.gov/22344294 DMTSONL DI DMTSONL DMTSONL DN Claritin/Singulair DMTSONL MI TTGKOY9 DMTSONL MN Leukotriene CysLT1 receptor (CYSLTR1) DMTSONL MT DTT DMTSONL MA Modulator DMTSONL RN Montelukast, a leukotriene receptor antagonist, for the treatment of persistent asthma in children aged 2 to 5 years. Pediatrics. 2001 Sep;108(3):E48. DMTSONL RU https://pubmed.ncbi.nlm.nih.gov/11533366 DMPQR1D DI DMPQR1D DMPQR1D DN Claudiximab DMPQR1D MI TT6PKBX DMPQR1D MN Claudin-18 (CLDN18) DMPQR1D MT DTT DMPQR1D RN Claudin 18.2 is a target for IMAB362 antibody in pancreatic neoplasms. Int J Cancer. 2014 Feb 1;134(3):731-9. DMPQR1D RU https://pubmed.ncbi.nlm.nih.gov/23900716 DMQSBX4 DI DMQSBX4 DMQSBX4 DN Clazosentan DMQSBX4 MI TTKRD0G DMQSBX4 MN Endothelin A receptor (EDNRA) DMQSBX4 MT DTT DMQSBX4 MA Antagonist DMQSBX4 RN Effects of the selective endothelin A (ET(A)) receptor antagonist Clazosentan on cerebral perfusion and cerebral oxygenation following severe subar... Acta Neurochir (Wien). 2007;149(9):911-8; discussion 918. DMQSBX4 RU https://pubmed.ncbi.nlm.nih.gov/17700991 DMQSBX4 DI DMQSBX4 DMQSBX4 DN Clazosentan DMQSBX4 MI TTCV6O0 DMQSBX4 MN Endothelin receptor (EDNR) DMQSBX4 MT DTT DMQSBX4 MA Antagonist DMQSBX4 RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMQSBX4 RU http://phrma-docs.phrma.org/files/dmfile/2018_Heart-Disease-and-Stroke_MID-Drug-List.pdf DMR21Q3 DI DMR21Q3 DMR21Q3 DN Clevudine DMR21Q3 MI TTS5K1M DMR21Q3 MN Hepatitis B virus Reverse transcriptase (HBV RT) DMR21Q3 MT DTT DMR21Q3 MA Inhibitor DMR21Q3 RN 2011 Pipeline of Bukwang. DMR21Q3 RU http://bkmedical.en.ecplaza.net/ DMSPN58 DI DMSPN58 DMSPN58 DN Clomethiazole DMSPN58 MI DEJVYAZ DMSPN58 MN Cytochrome P450 2A6 (CYP2A6) DMSPN58 MT DME DMSPN58 MA Metabolism DMSPN58 RN Summary of information on human CYP enzymes: human P450 metabolism data. Drug Metab Rev. 2002 Feb-May;34(1-2):83-448. DMSPN58 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=11996015 DMSPN58 DI DMSPN58 DMSPN58 DN Clomethiazole DMSPN58 MI DEPKLMQ DMSPN58 MN Cytochrome P450 2B6 (CYP2B6) DMSPN58 MT DME DMSPN58 MA Metabolism DMSPN58 RN Summary of information on human CYP enzymes: human P450 metabolism data. Drug Metab Rev. 2002 Feb-May;34(1-2):83-448. DMSPN58 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=11996015 DMSPN58 DI DMSPN58 DMSPN58 DN Clomethiazole DMSPN58 MI DE4LYSA DMSPN58 MN Cytochrome P450 3A4 (CYP3A4) DMSPN58 MT DME DMSPN58 MA Metabolism DMSPN58 RN Summary of information on human CYP enzymes: human P450 metabolism data. Drug Metab Rev. 2002 Feb-May;34(1-2):83-448. DMSPN58 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=11996015 DMSPN58 DI DMSPN58 DMSPN58 DN Clomethiazole DMSPN58 MI TTEX6LM DMSPN58 MN GABA(A) receptor gamma-3 (GABRG3) DMSPN58 MT DTT DMSPN58 MA Modulator DMSPN58 RN Electrophysiological actions of gamma-aminobutyric acid and clomethiazole on recombinant GABA(A) receptors. Eur J Pharmacol. 2002 Oct 11;452(3):255-62. DMSPN58 RU https://www.ncbi.nlm.nih.gov/pubmed/12359265 DMSPN58 DI DMSPN58 DMSPN58 DN Clomethiazole DMSPN58 MI DEGTFWK DMSPN58 MN Mephenytoin 4-hydroxylase (CYP2C19) DMSPN58 MT DME DMSPN58 MA Metabolism DMSPN58 RN Summary of information on human CYP enzymes: human P450 metabolism data. Drug Metab Rev. 2002 Feb-May;34(1-2):83-448. DMSPN58 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=11996015 DMFQ1WX DI DMFQ1WX DMFQ1WX DN CLS006 DMFQ1WX MI TTL3N71 DMFQ1WX MN Virus Replication (Viru Repli) DMFQ1WX MT DTT DMFQ1WX MA Inhibitor DMFQ1WX RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMFQ1WX RU http://phrma-docs.phrma.org/files/dmfile/MID_Skin_Diseases_2018_9_FINAL.pdf DMASPWR DI DMASPWR DMASPWR DN CM-2395 DMASPWR MI TTSQIFT DMASPWR MN 5-HT 1A receptor (HTR1A) DMASPWR MT DTT DMASPWR MA Agonist DMASPWR RN Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800031127) DMASPWR RU http://adisinsight.springer.com/drugs/800031127 DMASPWR DI DMASPWR DMASPWR DN CM-2395 DMASPWR MI TT4C8EA DMASPWR MN Dopamine D3 receptor (D3R) DMASPWR MT DTT DMASPWR MA Agonist DMASPWR RN Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800031127) DMASPWR RU http://adisinsight.springer.com/drugs/800031127 DMASPWR DI DMASPWR DMASPWR DN CM-2395 DMASPWR MI TTE0A2F DMASPWR MN Dopamine D4 receptor (D4R) DMASPWR MT DTT DMASPWR MA Agonist DMASPWR RN Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800031127) DMASPWR RU http://adisinsight.springer.com/drugs/800031127 DMASPWR DI DMASPWR DMASPWR DN CM-2395 DMASPWR MI TT5TPI6 DMASPWR MN Opioid receptor sigma 1 (OPRS1) DMASPWR MT DTT DMASPWR MA Agonist DMASPWR RN Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800031127) DMASPWR RU http://adisinsight.springer.com/drugs/800031127 DMLMN2F DI DMLMN2F DMLMN2F DN CM-AT DMLMN2F MI TT7MRGU DMLMN2F MN Chymotrypsin (CTR) DMLMN2F MT DTT DMLMN2F MA Modulator DMLMN2F RN Drugmakers dance with autism. Nat Biotechnol. 2010 Aug;28(8):772-4. DMLMN2F RU https://pubmed.ncbi.nlm.nih.gov/20697394 DMC4X7L DI DMC4X7L DMC4X7L DN CMS-024-02 DMC4X7L MI TTBH0VX DMC4X7L MN Histone deacetylase (HDAC) DMC4X7L MT DTT DMC4X7L MA Modulator DMC4X7L RN US patent application no. 2012,0302,505, Cyclodextrin-based polymers for therapeutic delivery. DMC4X7L RU http://www.google.com/patents/US20120302505 DM9Y3B5 DI DM9Y3B5 DM9Y3B5 DN CMX-001 DM9Y3B5 MI TTATL6Y DM9Y3B5 MN DNA-dependent DNA polymerase (DPOL) DM9Y3B5 MT DTT DM9Y3B5 MA Inhibitor DM9Y3B5 RN Detection of Molluscum Contagiosum Virus (MCV) DNA in the Plasma of an Immunocompromised Patient and Possible Reduction of MCV DNA With CMX-001. J Infect Dis. 2012 March 1; 205(5): 794-797. DM9Y3B5 RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3274371/ DMB4JPG DI DMB4JPG DMB4JPG DN CNTX-4975 DMB4JPG MI TTMI6F5 DMB4JPG MN Transient receptor potential cation channel V1 (TRPV1) DMB4JPG MT DTT DMB4JPG MA Agonist DMB4JPG RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMB4JPG RU http://phrma-docs.phrma.org/files/dmfile/MID_Neurological-Disorders-Drug-List_2018.pdf DMWZ2TU DI DMWZ2TU DMWZ2TU DN CO-1686 DMWZ2TU MI TTGKNB4 DMWZ2TU MN Epidermal growth factor receptor (EGFR) DMWZ2TU MT DTT DMWZ2TU MA Modulator DMWZ2TU RN Rociletinib in EGFR-mutated non-small-cell lung cancer. N Engl J Med. 2015 Apr 30;372(18):1700-9. DMWZ2TU RU https://pubmed.ncbi.nlm.nih.gov/25923550 DMN9ETB DI DMN9ETB DMN9ETB DN Contusugene ladenovec DMN9ETB MI TT7SBF5 DMN9ETB MN Cellular tumor antigen p53 (TP53) DMN9ETB MT DTT DMN9ETB MA Modulator DMN9ETB RN A review of contusugene ladenovec (Advexin) p53 therapy. Curr Opin Mol Ther. 2009 Feb;11(1):54-61. DMN9ETB RU https://pubmed.ncbi.nlm.nih.gov/19169960 DMA0WEK DI DMA0WEK DMA0WEK DN Coprexa DMA0WEK MI TT6RVLG DMA0WEK MN Superoxide dismutase Cu-Zn (SOD Cu-Zn) DMA0WEK MT DTT DMA0WEK MA Inhibitor DMA0WEK RN Copper binding by tetrathiomolybdate attenuates angiogenesis and tumor cell proliferation through the inhibition of superoxide dismutase 1. Clin Cancer Res. 2006 Aug 15;12(16):4974-82. DMA0WEK RU https://pubmed.ncbi.nlm.nih.gov/16914587 DMBS3UG DI DMBS3UG DMBS3UG DN CORT-125134 DMBS3UG MI TTYRL6O DMBS3UG MN Glucocorticoid receptor (NR3C1) DMBS3UG MT DTT DMBS3UG MA Antagonist DMBS3UG RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMBS3UG RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DMMEAOL DI DMMEAOL DMMEAOL DN Coversin DMMEAOL MI TTKANGO DMMEAOL MN Complement C5 (CO5) DMMEAOL MT DTT DMMEAOL MA Inhibitor DMMEAOL RN Use of the complement inhibitor Coversin to treat HSCT-associated TMA. Blood Adv. 2017 Jul 3;1(16):1254-1258. DMMEAOL RU https://pubmed.ncbi.nlm.nih.gov/29296765 DMZIM37 DI DMZIM37 DMZIM37 DN CP-868596 DMZIM37 MI TT8FYO9 DMZIM37 MN Platelet-derived growth factor receptor alpha (PDGFRA) DMZIM37 MT DTT DMZIM37 MA Modulator DMZIM37 RN The FLT3 and PDGFR inhibitor crenolanib is a substrate of the multidrug resistance protein ABCB1 but does not inhibit transport function at pharmacologically relevant concentrations.Invest New Drugs.2015 Apr;33(2):300-9. DMZIM37 RU https://www.ncbi.nlm.nih.gov/pubmed/25597754 DMZIM37 DI DMZIM37 DMZIM37 DN CP-868596 DMZIM37 MI TT6PKBN DMZIM37 MN Proto-oncogene c-Src (SRC) DMZIM37 MT DTT DMZIM37 MA Inhibitor DMZIM37 RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMZIM37 RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DM2EO5M DI DM2EO5M DM2EO5M DN CPC-211 DM2EO5M MI DEQPEMB DM2EO5M MN Glutathione S-transferase zeta-1 (GSTZ1) DM2EO5M MT DME DM2EO5M MA Metabolism DM2EO5M RN Personalized dosing of dichloroacetate using GSTZ1 clinical genotyping assay. Genet Test Mol Biomarkers. 2018 Apr;22(4):266-269. DM2EO5M RU https://pubmed.ncbi.nlm.nih.gov/29641284 DMPXOYJ DI DMPXOYJ DMPXOYJ DN CPI-0610 DMPXOYJ MI TTE4BSY DMPXOYJ MN Bromodomain and extraterminal domain protein (BET) DMPXOYJ MT DTT DMPXOYJ MA Inhibitor DMPXOYJ RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMPXOYJ RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DMPXOYJ DI DMPXOYJ DMPXOYJ DN CPI-0610 DMPXOYJ MI TTRA6BO DMPXOYJ MN Bromodomain-containing protein 4 (BRD4) DMPXOYJ MT DTT DMPXOYJ MA Modulator DMPXOYJ RN Targeting bromodomains: epigenetic readers of lysine acetylation.Nat Rev Drug Discov.2014 May;13(5):337-56. DMPXOYJ RU https://www.ncbi.nlm.nih.gov/pubmed/24751816 DM5XUQL DI DM5XUQL DM5XUQL DN CPI-613 DM5XUQL MI TTH8T6I DM5XUQL MN Alpha-ketoglutarate dehydrogenase (OGDH) DM5XUQL MT DTT DM5XUQL MA Modulator DM5XUQL RN A strategically designed small molecule attacks alpha-ketoglutarate dehydrogenase in tumor cells through a redox process. Cancer Metab. 2014 Mar 10;2(1):4. DM5XUQL RU https://pubmed.ncbi.nlm.nih.gov/24612826 DM62E7C DI DM62E7C DM62E7C DN CPL-7075 DM62E7C MI TTF8CQI DM62E7C MN Tumor necrosis factor (TNF) DM62E7C MT DTT DM62E7C MA Inhibitor DM62E7C RN Emerging drugs in neuropathic pain. Expert Opin Emerg Drugs. 2007 Mar;12(1):113-26. DM62E7C RU https://pubmed.ncbi.nlm.nih.gov/17355217 DM60TVK DI DM60TVK DM60TVK DN CQA 206-291 DM60TVK MI TTEX248 DM60TVK MN Dopamine D2 receptor (D2R) DM60TVK MT DTT DM60TVK MA Agonist DM60TVK RN The antiparkinsonian activity of CQA 206-291, a new D2 dopamine receptor agonist. Clin Neuropharmacol. 1989 Feb;12(1):55-9. DM60TVK RU https://pubmed.ncbi.nlm.nih.gov/2565766 DMKD2BQ DI DMKD2BQ DMKD2BQ DN Creatine ALS-08 DMKD2BQ MI DTPKTHL DMKD2BQ MN Creatine transporter 1 (SLC6A8) DMKD2BQ MT DTP DMKD2BQ MA Substrate DMKD2BQ RN Astrocytic -aminobutyric acid (GABA) transporters mediate guanidinoacetate transport in rat brain. 2018 Feb;113:1-7. DMKD2BQ RU http://www.ncbi.nlm.nih.gov/pubmed/29175673 DMKD2BQ DI DMKD2BQ DMKD2BQ DN Creatine ALS-08 DMKD2BQ MI TTZ1DV7 DMKD2BQ MN Mitochondrial function (MF) DMKD2BQ MT DTT DMKD2BQ MA Modulator DMKD2BQ RN The therapeutic role of creatine in Huntington's disease. Pharmacol Ther. 2005 Nov;108(2):193-207. DMKD2BQ RU https://pubmed.ncbi.nlm.nih.gov/16055197 DMKD2BQ DI DMKD2BQ DMKD2BQ DN Creatine ALS-08 DMKD2BQ MI DTZOKFJ DMKD2BQ MN Monocarboxylate transporter 12 (SLC16A12) DMKD2BQ MT DTP DMKD2BQ MA Substrate DMKD2BQ RN Mutation in the Monocarboxylate Transporter 12 Gene Affects Guanidinoacetate Excretion but Does Not Cause Glucosuria. J Am Soc Nephrol. 2016 May;27(5):1426-36. DMKD2BQ RU http://www.ncbi.nlm.nih.gov/pubmed/26376857 DM7QI29 DI DM7QI29 DM7QI29 DN Crenezumab DM7QI29 MI TTE4KHA DM7QI29 MN Amyloid beta A4 protein (APP) DM7QI29 MT DTT DM7QI29 MA Modulator DM7QI29 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2402). DM7QI29 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2402 DM5F24X DI DM5F24X DM5F24X DN Crocin DM5F24X MI DTUGYRD DM5F24X MN P-glycoprotein 1 (ABCB1) DM5F24X MT DTP DM5F24X MA Substrate DM5F24X RN Carotenoids reverse multidrug resistance in cancer cells by interfering with ABC-transporters. Phytomedicine. 2012 Aug 15;19(11):977-87. DM5F24X RU https://doi.org/10.1016/j.phymed.2012.05.010 DM67P0F DI DM67P0F DM67P0F DN CS-038 DM67P0F MI TTJ584C DM67P0F MN Peroxisome proliferator-activated receptor alpha (PPARA) DM67P0F MT DTT DM67P0F MA Modulator DM67P0F RN Determination of chiglitazar, a dual alpha/gamma peroxisome proliferator-activated receptor (PPAR) agonist, in human plasma by liquid chromatograph... Pharmazie. 2007 Nov;62(11):825-9. DM67P0F RU https://www.ncbi.nlm.nih.gov/pubmed/18065097 DM67P0F DI DM67P0F DM67P0F DN CS-038 DM67P0F MI TTZMAO3 DM67P0F MN Peroxisome proliferator-activated receptor gamma (PPAR-gamma) DM67P0F MT DTT DM67P0F MA Modulator DM67P0F RN Determination of chiglitazar, a dual alpha/gamma peroxisome proliferator-activated receptor (PPAR) agonist, in human plasma by liquid chromatograph... Pharmazie. 2007 Nov;62(11):825-9. DM67P0F RU https://www.ncbi.nlm.nih.gov/pubmed/18065097 DMSY0NE DI DMSY0NE DMSY0NE DN CS1001 DMSY0NE MI TT8ZLTI DMSY0NE MN Programmed cell death 1 ligand 1 (PD-L1) DMSY0NE MT DTT DMSY0NE RN GEMSTONE-301: a phase III clinical trial of CS1001 as consolidation therapy in patients with locally advanced/unresectable (stage III) non-small cell lung cancer (NSCLC) who did not have disease progression after prior concurrent/sequential chemoradiotherapy. Transl Lung Cancer Res. 2020 Oct;9(5):2008-2015. DMSY0NE RU https://pubmed.ncbi.nlm.nih.gov/33209620 DM1PV4Y DI DM1PV4Y DM1PV4Y DN CS-600G DM1PV4Y MI DEB3CV1 DM1PV4Y MN UDP-glucuronosyltransferase 2B7 (UGT2B7) DM1PV4Y MT DME DM1PV4Y MA Metabolism DM1PV4Y RN Exploring the metabolism of loxoprofen in liver microsomes: the role of cytochrome P450 and UDP-glucuronosyltransferase in its biotransformation. Pharmaceutics. 2018 Aug 2;10(3). pii: E112. DM1PV4Y RU https://www.ncbi.nlm.nih.gov/pubmed/?term=30072626 DM4CSDH DI DM4CSDH DM4CSDH DN CS-8958 DM4CSDH MI TT50QJ3 DM4CSDH MN Influenza Neuraminidase (Influ NA) DM4CSDH MT DTT DM4CSDH MA Inhibitor DM4CSDH RN Developing new antiviral agents for influenza treatment: what does the future hold Clin Infect Dis. 2009 Jan 1;48 Suppl 1:S3-13. DM4CSDH RU https://pubmed.ncbi.nlm.nih.gov/19067613 DMV574J DI DMV574J DMV574J DN CSL312 DMV574J MI TTMXD0O DMV574J MN Coagulation factor XII (F12) DMV574J MT DTT DMV574J MA Inhibitor DMV574J RN Clinical pipeline report, company report or official report of CSL Behring. DMV574J RU https://www.cslbehring.com/r-and-d/product-pipeline DMZJGVL DI DMZJGVL DMZJGVL DN CSL-654 DMZJGVL MI TTFEZ5Q DMZJGVL MN Coagulation factor IX (F9) DMZJGVL MT DTT DMZJGVL MA Modulator DMZJGVL RN Safety and pharmacokinetics of a novel recombinant fusion protein linking coagulation factor IX with albumin (rIX-FP) in hemophilia B patients. Blood. 2012 September 20; 120(12): 2405-2411. DMZJGVL RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3448255/ DMU2ZFK DI DMU2ZFK DMU2ZFK DN CT-2584 DMU2ZFK MI TTUAIKM DMU2ZFK MN Cholinephosphate cytidylyltransferase (PCYT1B) DMU2ZFK MT DTT DMU2ZFK MA Modulator DMU2ZFK RN Pharmacological inhibition of phosphatidylcholine biosynthesis is associated with induction of phosphatidylinositol accumulation and cytolysis of neoplastic cell lines. Cancer Res. 2000 Sep 15;60(18):5204-13. DMU2ZFK RU https://pubmed.ncbi.nlm.nih.gov/11016649 DMQPH29 DI DMQPH29 DMQPH29 DN Curcumin DMQPH29 MI TTXV4FI DMQPH29 MN Albendazole monooxygenase (CYP3A4) DMQPH29 MT DTT DMQPH29 MA Inhibitor DMQPH29 RN Structure-activity relationships for the inhibition of recombinant human cytochromes P450 by curcumin analogues. Eur J Med Chem. 2008 Aug;43(8):1621-31. DMQPH29 RU https://pubmed.ncbi.nlm.nih.gov/18249473 DMQPH29 DI DMQPH29 DMQPH29 DN Curcumin DMQPH29 MI TTE4KHA DMQPH29 MN Amyloid beta A4 protein (APP) DMQPH29 MT DTT DMQPH29 MA Inhibitor DMQPH29 RN Curcumin and dehydrozingerone derivatives: synthesis, radiolabeling, and evaluation for beta-amyloid plaque imaging. J Med Chem. 2006 Oct 5;49(20):6111-9. DMQPH29 RU https://pubmed.ncbi.nlm.nih.gov/17004725 DMQPH29 DI DMQPH29 DMQPH29 DN Curcumin DMQPH29 MI TTUNARX DMQPH29 MN Carbonic anhydrase (CA) DMQPH29 MT DTT DMQPH29 MA Inhibitor DMQPH29 RN Carbonic anhydrase inhibitors. Antioxidant polyphenols effectively inhibit mammalian isoforms I-XV. Bioorg Med Chem Lett. 2010 Sep 1;20(17):5050-3. DMQPH29 RU https://pubmed.ncbi.nlm.nih.gov/20674354 DMQPH29 DI DMQPH29 DMQPH29 DN Curcumin DMQPH29 MI TTHQPL7 DMQPH29 MN Carbonic anhydrase I (CA-I) DMQPH29 MT DTT DMQPH29 MA Inhibitor DMQPH29 RN Carbonic anhydrase inhibitors. Antioxidant polyphenols effectively inhibit mammalian isoforms I-XV. Bioorg Med Chem Lett. 2010 Sep 1;20(17):5050-3. DMQPH29 RU https://pubmed.ncbi.nlm.nih.gov/20674354 DMQPH29 DI DMQPH29 DMQPH29 DN Curcumin DMQPH29 MI TTANPDJ DMQPH29 MN Carbonic anhydrase II (CA-II) DMQPH29 MT DTT DMQPH29 MA Inhibitor DMQPH29 RN Carbonic anhydrase inhibitors. Antioxidant polyphenols effectively inhibit mammalian isoforms I-XV. Bioorg Med Chem Lett. 2010 Sep 1;20(17):5050-3. DMQPH29 RU https://pubmed.ncbi.nlm.nih.gov/20674354 DMQPH29 DI DMQPH29 DMQPH29 DN Curcumin DMQPH29 MI TTZHA0O DMQPH29 MN Carbonic anhydrase IV (CA-IV) DMQPH29 MT DTT DMQPH29 MA Inhibitor DMQPH29 RN Carbonic anhydrase inhibitors. Antioxidant polyphenols effectively inhibit mammalian isoforms I-XV. Bioorg Med Chem Lett. 2010 Sep 1;20(17):5050-3. DMQPH29 RU https://pubmed.ncbi.nlm.nih.gov/20674354 DMQPH29 DI DMQPH29 DMQPH29 DN Curcumin DMQPH29 MI TT2LVK8 DMQPH29 MN Carbonic anhydrase IX (CA-IX) DMQPH29 MT DTT DMQPH29 MA Inhibitor DMQPH29 RN Carbonic anhydrase inhibitors. Antioxidant polyphenols effectively inhibit mammalian isoforms I-XV. Bioorg Med Chem Lett. 2010 Sep 1;20(17):5050-3. DMQPH29 RU https://pubmed.ncbi.nlm.nih.gov/20674354 DMQPH29 DI DMQPH29 DMQPH29 DN Curcumin DMQPH29 MI TTCFSPE DMQPH29 MN Carbonic anhydrase VI (CA-VI) DMQPH29 MT DTT DMQPH29 MA Inhibitor DMQPH29 RN Carbonic anhydrase inhibitors. Antioxidant polyphenols effectively inhibit mammalian isoforms I-XV. Bioorg Med Chem Lett. 2010 Sep 1;20(17):5050-3. DMQPH29 RU https://pubmed.ncbi.nlm.nih.gov/20674354 DMQPH29 DI DMQPH29 DMQPH29 DN Curcumin DMQPH29 MI TTSYM0R DMQPH29 MN Carbonic anhydrase XII (CA-XII) DMQPH29 MT DTT DMQPH29 MA Inhibitor DMQPH29 RN Carbonic anhydrase inhibitors. Antioxidant polyphenols effectively inhibit mammalian isoforms I-XV. Bioorg Med Chem Lett. 2010 Sep 1;20(17):5050-3. DMQPH29 RU https://pubmed.ncbi.nlm.nih.gov/20674354 DMQPH29 DI DMQPH29 DMQPH29 DN Curcumin DMQPH29 MI TTEYTKG DMQPH29 MN Carbonic anhydrase XIV (CA-XIV) DMQPH29 MT DTT DMQPH29 MA Inhibitor DMQPH29 RN Carbonic anhydrase inhibitors. Antioxidant polyphenols effectively inhibit mammalian isoforms I-XV. Bioorg Med Chem Lett. 2010 Sep 1;20(17):5050-3. DMQPH29 RU https://pubmed.ncbi.nlm.nih.gov/20674354 DMQPH29 DI DMQPH29 DMQPH29 DN Curcumin DMQPH29 MI TTHVCUP DMQPH29 MN DNA [cytosine-5]-methyltransferase (DNMT) DMQPH29 MT DTT DMQPH29 MA Inhibitor DMQPH29 RN Novel and selective DNA methyltransferase inhibitors: Docking-based virtual screening and experimental evaluation. Bioorg Med Chem. 2010 Jan 15;18(2):822-9. DMQPH29 RU https://pubmed.ncbi.nlm.nih.gov/20006515 DMQPH29 DI DMQPH29 DMQPH29 DN Curcumin DMQPH29 MI TT6VZ78 DMQPH29 MN DNA [cytosine-5]-methyltransferase 3B (DNMT3B) DMQPH29 MT DTT DMQPH29 MA Inhibitor DMQPH29 RN Novel and selective DNA methyltransferase inhibitors: Docking-based virtual screening and experimental evaluation. Bioorg Med Chem. 2010 Jan 15;18(2):822-9. DMQPH29 RU https://pubmed.ncbi.nlm.nih.gov/20006515 DMQPH29 DI DMQPH29 DMQPH29 DN Curcumin DMQPH29 MI TTHY57M DMQPH29 MN Matrix metalloproteinase-13 (MMP-13) DMQPH29 MT DTT DMQPH29 MA Inhibitor DMQPH29 RN High throughput screening of potentially selective MMP-13 exosite inhibitors utilizing a triple-helical FRET substrate. Bioorg Med Chem. 2009 Feb 1;17(3):990-1005. DMQPH29 RU https://pubmed.ncbi.nlm.nih.gov/18358729 DMQPH29 DI DMQPH29 DMQPH29 DN Curcumin DMQPH29 MI TT6X50U DMQPH29 MN Matrix metalloproteinase-9 (MMP-9) DMQPH29 MT DTT DMQPH29 MA Inhibitor DMQPH29 RN Synthesis and biological evaluation of curcuminoid pyrazoles as new therapeutic agents in inflammatory bowel disease: effect on matrix metalloprote... Bioorg Med Chem. 2009 Feb 1;17(3):1290-6. DMQPH29 RU https://pubmed.ncbi.nlm.nih.gov/19128977 DMQPH29 DI DMQPH29 DMQPH29 DN Curcumin DMQPH29 MI TT0JLSD DMQPH29 MN Multidrug resistance protein (MDR) DMQPH29 MT DTT DMQPH29 MA Inhibitor DMQPH29 RN Thiazolides: a new class of antiviral drugs. Expert Opin Drug Metab Toxicol. 2009 Jun;5(6):667-74. 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DMQPH29 RU https://pubmed.ncbi.nlm.nih.gov/18077363 DMQPH29 DI DMQPH29 DMQPH29 DN Curcumin DMQPH29 MI DTUGYRD DMQPH29 MN P-glycoprotein 1 (ABCB1) DMQPH29 MT DTP DMQPH29 MA Substrate DMQPH29 RN Mammalian drug efflux transporters of the ATP binding cassette (ABC) family in multidrug resistance: A review of the past decade. Cancer Lett. 2016 Jan 1;370(1):153-64. DMQPH29 RU http://www.ncbi.nlm.nih.gov/pubmed/26499806 DMQPH29 DI DMQPH29 DMQPH29 DN Curcumin DMQPH29 MI TT8NGED DMQPH29 MN Prostaglandin G/H synthase 1 (COX-1) DMQPH29 MT DTT DMQPH29 MA Inhibitor DMQPH29 RN Design, synthesis, biological evaluation and molecular docking of curcumin analogues as antioxidant, cyclooxygenase inhibitory and anti-inflammator... Bioorg Med Chem Lett. 2005 Apr 1;15(7):1793-7. DMQPH29 RU https://pubmed.ncbi.nlm.nih.gov/15780608 DMQPH29 DI DMQPH29 DMQPH29 DN Curcumin DMQPH29 MI TTVKILB DMQPH29 MN Prostaglandin G/H synthase 2 (COX-2) DMQPH29 MT DTT DMQPH29 MA Inhibitor DMQPH29 RN Design, synthesis, biological evaluation and molecular docking of curcumin analogues as antioxidant, cyclooxygenase inhibitory and anti-inflammator... Bioorg Med Chem Lett. 2005 Apr 1;15(7):1793-7. DMQPH29 RU https://pubmed.ncbi.nlm.nih.gov/15780608 DMQPH29 DI DMQPH29 DMQPH29 DN Curcumin DMQPH29 MI DEYGVN4 DMQPH29 MN UDP-glucuronosyltransferase 1A1 (UGT1A1) DMQPH29 MT DME DMQPH29 MA Metabolism DMQPH29 RN Differential and special properties of the major human UGT1-encoded gastrointestinal UDP-glucuronosyltransferases enhance potential to control chemical uptake. J Biol Chem. 2004 Jan 9;279(2):1429-41. DMQPH29 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=14557274 DMQPH29 DI DMQPH29 DMQPH29 DN Curcumin DMQPH29 MI DEZO4N3 DMQPH29 MN UDP-glucuronosyltransferase 1A7 (UGT1A7) DMQPH29 MT DME DMQPH29 MA Metabolism DMQPH29 RN Differential and special properties of the major human UGT1-encoded gastrointestinal UDP-glucuronosyltransferases enhance potential to control chemical uptake. J Biol Chem. 2004 Jan 9;279(2):1429-41. DMQPH29 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=14557274 DMQPH29 DI DMQPH29 DMQPH29 DN Curcumin DMQPH29 MI DE2GB8N DMQPH29 MN UDP-glucuronosyltransferase 1A8 (UGT1A8) DMQPH29 MT DME DMQPH29 MA Metabolism DMQPH29 RN Differential and special properties of the major human UGT1-encoded gastrointestinal UDP-glucuronosyltransferases enhance potential to control chemical uptake. J Biol Chem. 2004 Jan 9;279(2):1429-41. 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DMQPH29 RU https://pubmed.ncbi.nlm.nih.gov/19388706 DMIQ31Y DI DMIQ31Y DMIQ31Y DN Custirsen DMIQ31Y MI TTRL76H DMIQ31Y MN Clusterin messenger RNA (Clusterin mRNA) DMIQ31Y MT DTT DMIQ31Y RN Over-expression of clusterin is a resistance factor to the anti-cancer effect of histone deacetylase inhibitors. Eur J Cancer. 2009 Jul;45(10):1846-54. DMIQ31Y RU https://pubmed.ncbi.nlm.nih.gov/19342222 DM0JA9N DI DM0JA9N DM0JA9N DN Cyrtominetin DM0JA9N MI TT5FLYB DM0JA9N MN Staphylococcus Alpha-hemolysin (Stap-coc hly) DM0JA9N MT DTT DM0JA9N MA Modulator DM0JA9N RN Molecular insight into the inhibition mechanism of cyrtominetin to alpha-hemolysin by molecular dynamics simulation. Eur J Med Chem. 2013 Apr;62:320-8. DM0JA9N RU https://pubmed.ncbi.nlm.nih.gov/23376250 DMUF0BJ DI DMUF0BJ DMUF0BJ DN CYTISINE DMUF0BJ MI TTF4E0J DMUF0BJ MN Neuronal acetylcholine receptor alpha-2 (CHRNA2) DMUF0BJ MT DTT DMUF0BJ MA Inhibitor DMUF0BJ RN Synthesis and pharmacological evaluation of novel 9- and 10-substituted cytisine derivatives. Nicotinic ligands of enhanced subtype selectivity. J Med Chem. 2006 May 4;49(9):2673-6. DMUF0BJ RU https://pubmed.ncbi.nlm.nih.gov/16640326 DMUF0BJ DI DMUF0BJ DMUF0BJ DN CYTISINE DMUF0BJ MI TT4H1MQ DMUF0BJ MN Neuronal acetylcholine receptor alpha-4 (CHRNA4) DMUF0BJ MT DTT DMUF0BJ MA Inhibitor DMUF0BJ RN Epibatidine isomers and analogues: structure-activity relationships. Bioorg Med Chem Lett. 2006 Nov 1;16(21):5493-7. DMUF0BJ RU https://pubmed.ncbi.nlm.nih.gov/16934977 DMUF0BJ DI DMUF0BJ DMUF0BJ DN CYTISINE DMUF0BJ MI TTLA931 DMUF0BJ MN Neuronal acetylcholine receptor alpha-7 (CHRNA7) DMUF0BJ MT DTT DMUF0BJ MA Inhibitor DMUF0BJ RN 3,5-Bicyclic aryl piperidines: a novel class of alpha4beta2 neuronal nicotinic receptor partial agonists for smoking cessation. Bioorg Med Chem Lett. 2005 Nov 15;15(22):4889-97. DMUF0BJ RU https://pubmed.ncbi.nlm.nih.gov/16171993 DMUF0BJ DI DMUF0BJ DMUF0BJ DN CYTISINE DMUF0BJ MI TT5KPZR DMUF0BJ MN Neuronal acetylcholine receptor beta-2 (CHRNB2) DMUF0BJ MT DTT DMUF0BJ MA Inhibitor DMUF0BJ RN Epibatidine isomers and analogues: structure-activity relationships. Bioorg Med Chem Lett. 2006 Nov 1;16(21):5493-7. 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DMUF0BJ RU https://pubmed.ncbi.nlm.nih.gov/18356044 DMUF0BJ DI DMUF0BJ DMUF0BJ DN CYTISINE DMUF0BJ MI TTJSZTB DMUF0BJ MN Nicotinic acetylcholine receptor (nAChR) DMUF0BJ MT DTT DMUF0BJ MA Antagonist DMUF0BJ RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMUF0BJ RU http://phrma-docs.phrma.org/files/dmfile/MID_Mental-Illness-2017-Drug-List_Final.pdf DMYJ2QB DI DMYJ2QB DMYJ2QB DN D2A21 DMYJ2QB MI TTXT4D5 DMYJ2QB MN Bacterial Cell membrane (Bact CM) DMYJ2QB MT DTT DMYJ2QB MA Modulator DMYJ2QB RN In Vitro Microbicidal Activities of Cecropin Peptides D2A21 and D4E1 and Gel Formulations Containing 0.1 to 2% D2A21 against Chlamydia trachomatis. Antimicrob Agents Chemother. 2002 January; 46(1): 34-41. DMYJ2QB RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC126975/ DM9FAJM DI DM9FAJM DM9FAJM DN D-5519 DM9FAJM MI TTPNQAC DM9FAJM MN Estrogen-related receptor-alpha (ESRRA) DM9FAJM MT DTT DM9FAJM MA Modulator DM9FAJM RN Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800007199) DM9FAJM RU http://adisinsight.springer.com/drugs/800007199 DM6S4R2 DI DM6S4R2 DM6S4R2 DN DA-3031 DM6S4R2 MI TT5TQ2W DM6S4R2 MN Granulocyte colony-stimulating factor (CSF3) DM6S4R2 MT DTT DM6S4R2 MA Modulator DM6S4R2 RN A randomized, multi-center, open-label, phase II study of once-per-cycle DA-3031, a biosimilar pegylated G-CSF, compared with daily filgrastim in patients receiving TAC chemotherapy for early-stage breast cancer.Invest New Drugs.2013 Oct;31(5):1300-6. 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DMRDZ4X RU https://www.ncbi.nlm.nih.gov/pubmed/?term=20551237 DMKNCVM DI DMKNCVM DMKNCVM DN Dalcetrapib DMKNCVM MI TTFQAYR DMKNCVM MN Cholesteryl ester transfer protein (CETP) DMKNCVM MT DTT DMKNCVM MA Inhibitor DMKNCVM RN Clinical pipeline report, company report or official report of Roche (2009). DMKNCVM RU http://www.roche.com/research_and_development/pipeline/roche_pharma_pipeline.htm DMKNCVM DI DMKNCVM DMKNCVM DN Dalcetrapib DMKNCVM MI DE4LYSA DMKNCVM MN Cytochrome P450 3A4 (CYP3A4) DMKNCVM MT DME DMKNCVM MA Metabolism DMKNCVM RN In vitro and in vivo assessment of the effect of dalcetrapib on a panel of CYP substrates. Curr Med Res Opin. 2009 Apr;25(4):891-902. DMKNCVM RU https://www.ncbi.nlm.nih.gov/pubmed/?term=19245299 DM1C95G DI DM1C95G DM1C95G DN DARE-BV1 DM1C95G MI TTUWYEA DM1C95G MN Bacterial 50S ribosomal RNA (Bact 50S rRNA) DM1C95G MT DTT DM1C95G RN Characterization of Escherichia coli 50S ribosomal protein L31. FEMS Microbiol Lett. 1999 Nov 15;180(2):345-9. DM1C95G RU https://pubmed.ncbi.nlm.nih.gov/10556732 DMR2JD4 DI DMR2JD4 DMR2JD4 DN Darotropium + 642444 DMR2JD4 MI TTZ9SOR DMR2JD4 MN Muscarinic acetylcholine receptor M1 (CHRM1) DMR2JD4 MT DTT DMR2JD4 MA Agonist DMR2JD4 RN Clinical pipeline report, company report or official report of GlaxoSmithKline (2009). DMR2JD4 RU http://www.gsk.com/investors/product_pipeline/docs/gsk-pipeline-feb09.pdf DM2FV5N DI DM2FV5N DM2FV5N DN Darunavir + cobicistat DM2FV5N MI TT1D53B DM2FV5N MN COVID-19 3C-like protease (3CLpro) DM2FV5N MT DTT DM2FV5N MA Inhibitor DM2FV5N RN Coronavirus puts drug repurposing on the fast track. Nat Biotechnol. 2020 Apr;38(4):379-381. DM2FV5N RU https://pubmed.ncbi.nlm.nih.gov/32205870 DMF3V01 DI DMF3V01 DMF3V01 DN Darunavir + ritonavir + favipiravir + hydroxychloroquine DMF3V01 MI TTZGK1R DMF3V01 MN HUMAN glycosylation of host receptor (GHR) DMF3V01 MT DTT DMF3V01 MA Inhibitor DMF3V01 RN Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro. Cell Res. 2020 Mar;30(3):269-271. DMF3V01 RU https://pubmed.ncbi.nlm.nih.gov/32020029 DMF3V01 DI DMF3V01 DMF3V01 DN Darunavir + ritonavir + favipiravir + hydroxychloroquine DMF3V01 MI TTD16BI DMF3V01 MN HUMAN pH-dependent viral fusion/replication (pH-DVF/R) DMF3V01 MT DTT DMF3V01 MA Inhibitor DMF3V01 RN Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro. Cell Res. 2020 Mar;30(3):269-271. DMF3V01 RU https://pubmed.ncbi.nlm.nih.gov/32020029 DMF3V01 DI DMF3V01 DMF3V01 DN Darunavir + ritonavir + favipiravir + hydroxychloroquine DMF3V01 MI TT3A1EZ DMF3V01 MN HUMAN toll-like receptor 7/9 signalling pathway (TLR7/9 pathway) DMF3V01 MT DTT DMF3V01 MA Inhibitor DMF3V01 RN Mechanisms of action of hydroxychloroquine and chloroquine: implications for rheumatology. Nat Rev Rheumatol. 2020 Mar;16(3):155-166. DMF3V01 RU https://pubmed.ncbi.nlm.nih.gov/32034323 DMN9BO3 DI DMN9BO3 DMN9BO3 DN Darunavir + ritonavir + oseltamivir + hydroxychloroquine DMN9BO3 MI TTZGK1R DMN9BO3 MN HUMAN glycosylation of host receptor (GHR) DMN9BO3 MT DTT DMN9BO3 MA Inhibitor DMN9BO3 RN Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro. Cell Res. 2020 Mar;30(3):269-271. DMN9BO3 RU https://pubmed.ncbi.nlm.nih.gov/32020029 DMN9BO3 DI DMN9BO3 DMN9BO3 DN Darunavir + ritonavir + oseltamivir + hydroxychloroquine DMN9BO3 MI TTD16BI DMN9BO3 MN HUMAN pH-dependent viral fusion/replication (pH-DVF/R) DMN9BO3 MT DTT DMN9BO3 MA Inhibitor DMN9BO3 RN Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro. Cell Res. 2020 Mar;30(3):269-271. DMN9BO3 RU https://pubmed.ncbi.nlm.nih.gov/32020029 DMN9BO3 DI DMN9BO3 DMN9BO3 DN Darunavir + ritonavir + oseltamivir + hydroxychloroquine DMN9BO3 MI TT3A1EZ DMN9BO3 MN HUMAN toll-like receptor 7/9 signalling pathway (TLR7/9 pathway) DMN9BO3 MT DTT DMN9BO3 MA Inhibitor DMN9BO3 RN Mechanisms of action of hydroxychloroquine and chloroquine: implications for rheumatology. Nat Rev Rheumatol. 2020 Mar;16(3):155-166. DMN9BO3 RU https://pubmed.ncbi.nlm.nih.gov/32034323 DMN8DQH DI DMN8DQH DMN8DQH DN Darusentan DMN8DQH MI TTKRD0G DMN8DQH MN Endothelin A receptor (EDNRA) DMN8DQH MT DTT DMN8DQH MA Antagonist DMN8DQH RN Endothelin ETA receptor blockade with darusentan increases sodium and potassium excretion in aging rats. J Cardiovasc Pharmacol. 2006 Mar;47(3):456-62. DMN8DQH RU https://pubmed.ncbi.nlm.nih.gov/16633090 DMD7K9X DI DMD7K9X DMD7K9X DN Davunetide DMD7K9X MI TTS87KH DMD7K9X MN Microtubule-associated protein tau (MAPT) DMD7K9X MT DTT DMD7K9X MA Modulator DMD7K9X RN Microtubules (tau) as an emerging therapeutic target: NAP (davunetide). Curr Pharm Des. 2011;17(31):3413-7. DMD7K9X RU https://pubmed.ncbi.nlm.nih.gov/21902667 DMUX7Z8 DI DMUX7Z8 DMUX7Z8 DN DE-117 DMUX7Z8 MI TT1ZAVI DMUX7Z8 MN Prostaglandin E2 receptor EP2 (PTGER2) DMUX7Z8 MT DTT DMUX7Z8 MA Agonist DMUX7Z8 RN Clinical pipeline report, company report or official report of Santen Pharmaceutical. DMUX7Z8 RU http://www.santeninc.com/research/moa/ DM0GUV2 DI DM0GUV2 DM0GUV2 DN DE-766 DM0GUV2 MI TTGKNB4 DM0GUV2 MN Epidermal growth factor receptor (EGFR) DM0GUV2 MT DTT DM0GUV2 MA Modulator DM0GUV2 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1797). DM0GUV2 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1797 DM2R15Q DI DM2R15Q DM2R15Q DN DENBUFYLLINE DM2R15Q MI TTZ97H5 DM2R15Q MN Phosphodiesterase 4A (PDE4A) DM2R15Q MT DTT DM2R15Q MA Inhibitor DM2R15Q RN Pyrazolopyrimidine-2,4-dione sulfonamides: novel and selective calcitonin inducers. J Med Chem. 2002 May 23;45(11):2342-5. DM2R15Q RU https://pubmed.ncbi.nlm.nih.gov/12014973 DM2R15Q DI DM2R15Q DM2R15Q DN DENBUFYLLINE DM2R15Q MI TTVIAT9 DM2R15Q MN Phosphodiesterase 4B (PDE4B) DM2R15Q MT DTT DM2R15Q MA Inhibitor DM2R15Q RN Pyrazolopyrimidine-2,4-dione sulfonamides: novel and selective calcitonin inducers. J Med Chem. 2002 May 23;45(11):2342-5. DM2R15Q RU https://pubmed.ncbi.nlm.nih.gov/12014973 DM2R15Q DI DM2R15Q DM2R15Q DN DENBUFYLLINE DM2R15Q MI TTSKMI8 DM2R15Q MN Phosphodiesterase 4D (PDE4D) DM2R15Q MT DTT DM2R15Q MA Inhibitor DM2R15Q RN Pyrazolopyrimidine-2,4-dione sulfonamides: novel and selective calcitonin inducers. J Med Chem. 2002 May 23;45(11):2342-5. DM2R15Q RU https://pubmed.ncbi.nlm.nih.gov/12014973 DM2ATZB DI DM2ATZB DM2ATZB DN Deoxynojirimycin DM2ATZB MI TTHCF4J DM2ATZB MN Alpha-glucosidase (GLA) DM2ATZB MT DTT DM2ATZB MA Inhibitor DM2ATZB RN Nitrogen-in-the-ring pyranoses and furanoses: structural basis of inhibition of mammalian glycosidases. J Med Chem. 1994 Oct 28;37(22):3701-6. DM2ATZB RU https://pubmed.ncbi.nlm.nih.gov/7966130 DM2ATZB DI DM2ATZB DM2ATZB DN Deoxynojirimycin DM2ATZB MI TTXWASR DM2ATZB MN Intestinal maltase-glucoamylase (MGAM) DM2ATZB MT DTT DM2ATZB MA Inhibitor DM2ATZB RN Nitrogen-in-the-ring pyranoses and furanoses: structural basis of inhibition of mammalian glycosidases. J Med Chem. 1994 Oct 28;37(22):3701-6. DM2ATZB RU https://pubmed.ncbi.nlm.nih.gov/7966130 DM2ATZB DI DM2ATZB DM2ATZB DN Deoxynojirimycin DM2ATZB MI TTLPC70 DM2ATZB MN Lysosomal alpha-glucosidase (GAA) DM2ATZB MT DTT DM2ATZB MA Inhibitor DM2ATZB RN In vitro inhibition of glycogen-degrading enzymes and glycosidases by six-membered sugar mimics and their evaluation in cell cultures. Bioorg Med Chem. 2008 Aug 1;16(15):7330-6. DM2ATZB RU https://pubmed.ncbi.nlm.nih.gov/18595718 DMDLU4Z DI DMDLU4Z DMDLU4Z DN Desmoteplase DMDLU4Z MI TTP86E2 DMDLU4Z MN Plasminogen (PLG) DMDLU4Z MT DTT DMDLU4Z MA Activator DMDLU4Z RN Vampire bat salivary plasminogen activator (desmoteplase): a unique fibrinolytic enzyme that does not promote neurodegeneration. Stroke. 2003 Feb;34(2):537-43. DMDLU4Z RU https://pubmed.ncbi.nlm.nih.gov/12574572 DMRH291 DI DMRH291 DMRH291 DN Dexanabinol DMRH291 MI TT9IK2Z DMRH291 MN N-methyl-D-aspartate receptor (NMDAR) DMRH291 MT DTT DMRH291 MA Antagonist DMRH291 RN Emerging treatments for traumatic brain injury. Expert Opin Emerg Drugs. 2009 Mar;14(1):67-84. DMRH291 RU https://pubmed.ncbi.nlm.nih.gov/19249984 DM1WNGJ DI DM1WNGJ DM1WNGJ DN DFP-10917 DM1WNGJ MI TTABD5E DM1WNGJ MN DNA replication (DNA repli) DM1WNGJ MT DTT DM1WNGJ MA Inhibitor DM1WNGJ RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DM1WNGJ RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DMOUGX1 DI DMOUGX1 DMOUGX1 DN Diamyd DMOUGX1 MI TT7UY6K DMOUGX1 MN Glutamate decarboxylase 2 (GAD2) DMOUGX1 MT DTT DMOUGX1 MA Immunomodulator DMOUGX1 RN Clinical pipeline report, company report or official report of Diamyd Medical. DMOUGX1 RU http://www.diamyd.com/docs/gadProducts.aspx?section=products DM4XBM7 DI DM4XBM7 DM4XBM7 DN DiaPep-277 DM4XBM7 MI TT9HL5R DM4XBM7 MN Mitochondrial matrix protein P1 (HSPD1) DM4XBM7 MT DTT DM4XBM7 MA Modulator DM4XBM7 RN Therapy with the hsp60 peptide DiaPep277 in C-peptide positive type 1 diabetes patients. Diabetes Metab Res Rev. 2007 May;23(4):269-75. DM4XBM7 RU https://pubmed.ncbi.nlm.nih.gov/17024692 DMHZBEO DI DMHZBEO DMHZBEO DN Difelikefalin DMHZBEO MI TTQW87Y DMHZBEO MN Opioid receptor kappa (OPRK1) DMHZBEO MT DTT DMHZBEO MA Agonist DMHZBEO RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMHZBEO RU http://phrma-docs.phrma.org/files/dmfile/MID_Skin_Diseases_2018_9_FINAL.pdf DMU4T9Y DI DMU4T9Y DMU4T9Y DN Dimesna DMU4T9Y MI DTQ23VB DMU4T9Y MN Organic anion transporter 1 (SLC22A6) DMU4T9Y MT DTP DMU4T9Y MA Substrate DMU4T9Y RN In vitro and in vivo assessment of renal drug transporters in the disposition of mesna and dimesna. J Clin Pharmacol. 2012 Apr;52(4):530-42. DMU4T9Y RU http://www.ncbi.nlm.nih.gov/pubmed/21505084 DMU4T9Y DI DMU4T9Y DMU4T9Y DN Dimesna DMU4T9Y MI DTVP67E DMU4T9Y MN Organic anion transporter 3 (SLC22A8) DMU4T9Y MT DTP DMU4T9Y MA Substrate DMU4T9Y RN In vitro and in vivo assessment of renal drug transporters in the disposition of mesna and dimesna. J Clin Pharmacol. 2012 Apr;52(4):530-42. DMU4T9Y RU http://www.ncbi.nlm.nih.gov/pubmed/21505084 DM19CFZ DI DM19CFZ DM19CFZ DN DIMS-0150 DM19CFZ MI TTKLNRV DM19CFZ MN NFKB messenger RNA (NFKB mRNA) DM19CFZ MT DTT DM19CFZ RN News and Analysis. Nature Reviews Drug Discovery 12, 179 (March 2013). DM19CFZ RU http://www.nature.com/nrd/journal/v12/n3/full/nrd3963.html DMG8U6M DI DMG8U6M DMG8U6M DN DIPROTEVERINE HYDROCHLORIDE DMG8U6M MI TT5HONZ DMG8U6M MN Calcium channel unspecific (CaC) DMG8U6M MT DTT DMG8U6M MA Antagonist DMG8U6M RN Prenatal toxicity studies in rats and rabbits with the calcium channel blocker diproteverine. Reprod Toxicol. 1996 Jan-Feb;10(1):43-9. DMG8U6M RU https://pubmed.ncbi.nlm.nih.gov/8998385 DM64QG9 DI DM64QG9 DM64QG9 DN Diquafosol DM64QG9 MI TTOZHQC DM64QG9 MN P2Y purinoceptor 2 (P2RY2) DM64QG9 MT DTT DM64QG9 MA Agonist DM64QG9 RN Emerging drugs for the treatment of chronic obstructive pulmonary disease. Expert Opin Emerg Drugs. 2006 May;11(2):275-91. DM64QG9 RU https://pubmed.ncbi.nlm.nih.gov/16634702 DMJS8V3 DI DMJS8V3 DMJS8V3 DN Disufenton sodium DMJS8V3 MI TT8E7Z0 DMJS8V3 MN Free radical (FRD) DMJS8V3 MT DTT DMJS8V3 MA Modulator DMJS8V3 RN NXY-059, a free radical--trapping agent, substantially lessens the functional disability resulting from cerebral ischemia in a primate species. Stroke. 2001 Jan;32(1):190-8. DMJS8V3 RU https://pubmed.ncbi.nlm.nih.gov/11136936 DMMKGBP DI DMMKGBP DMMKGBP DN D-Methionine DMMKGBP MI TTZL0OI DMMKGBP MN Methionine aminopeptidase 2 (METAP2) DMMKGBP MT DTT DMMKGBP MA Inhibitor DMMKGBP RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMMKGBP RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMO7BQS DI DMO7BQS DMO7BQS DN DMP-444 DMO7BQS MI TT38RM1 DMO7BQS MN Glycoprotein IIb/IIIa receptor (GPIIb/IIIa) DMO7BQS MT DTT DMO7BQS MA Modulator DMO7BQS RN Evaluation of Tc-99m-labeled glycoprotein IIb/IIIa receptor antagonist DMP444 SPECT in patients with infective endocarditis. Clin Nucl Med. 2003 Jun;28(6):480-4. DMO7BQS RU https://pubmed.ncbi.nlm.nih.gov/12911097 DMQLSMB DI DMQLSMB DMQLSMB DN Dociparstat sodium DMQLSMB MI TTSG7Q5 DMQLSMB MN Platelet factor 4 (PF4) DMQLSMB MT DTT DMQLSMB MA Inhibitor DMQLSMB RN Clinical pipeline report, company report or official report of Chimerix. DMQLSMB RU https://www.chimerix.com/our-science/dstat/ DMQLSMB DI DMQLSMB DMQLSMB DN Dociparstat sodium DMQLSMB MI TT4UGTF DMQLSMB MN Stromal cell-derived factor 1 (CXCL12) DMQLSMB MT DTT DMQLSMB MA Inhibitor DMQLSMB RN Clinical pipeline report, company report or official report of Chimerix. DMQLSMB RU https://www.chimerix.com/our-science/dstat/ DMH8IT5 DI DMH8IT5 DMH8IT5 DN Donaperminogene seltoplasmid DMH8IT5 MI TT4V2JM DMH8IT5 MN Hepatocyte growth factor (HGF) DMH8IT5 MT DTT DMH8IT5 MA Replacement DMH8IT5 RN Clinical pipeline report, company report or official report of ViroMed. DMH8IT5 RU http://menu.itooza.com/cmsupload/contdown.php?sn=20190912100403_fd_image_119_65_142__1669.pdf&rsn=ViroMed_May_30_2018.pdf DM97S10 DI DM97S10 DM97S10 DN DP-b99 DM97S10 MI TT6X50U DM97S10 MN Matrix metalloproteinase-9 (MMP-9) DM97S10 MT DTT DM97S10 MA Inhibitor DM97S10 RN DP-b99 modulates matrix metalloproteinase activity and neuronal plasticity. PLoS One. 2014 Jun 11;9(6):e99789. DM97S10 RU https://pubmed.ncbi.nlm.nih.gov/24918931 DMWUN1S DI DMWUN1S DMWUN1S DN Drisapersen DMWUN1S MI TTWLFXU DMWUN1S MN Dystrophin messenger RNA (DMD mRNA) DMWUN1S MT DTT DMWUN1S RN PRO-051, an antisense oligonucleotide for the potential treatment of Duchenne muscular dystrophy. Curr Opin Mol Ther. 2010 Aug;12(4):478-86. DMWUN1S RU https://pubmed.ncbi.nlm.nih.gov/20677099 DMM0HAE DI DMM0HAE DMM0HAE DN DSC-127 DMM0HAE MI TTOISYB DMM0HAE MN Proto-oncogene Mas (MAS) DMM0HAE MT DTT DMM0HAE MA Agonist DMM0HAE RN New therapeutic pathways in the RAS. J Renin Angiotensin Aldosterone Syst. 2012 Dec;13(4):505-8. DMM0HAE RU https://pubmed.ncbi.nlm.nih.gov/23166114 DM6P8HU DI DM6P8HU DM6P8HU DN Dutasteride + tamsulosin DM6P8HU MI TTNGILX DM6P8HU MN Adrenergic receptor alpha-1A (ADRA1A) DM6P8HU MT DTT DM6P8HU MA Antagonist DM6P8HU RN Clinical pipeline report, company report or official report of GlaxoSmithKline (2009). DM6P8HU RU http://www.gsk.com/investors/product_pipeline/docs/gsk-pipeline-feb09.pdf DM6P8HU DI DM6P8HU DM6P8HU DN Dutasteride + tamsulosin DM6P8HU MI TT2A0DR DM6P8HU MN Oxo-5-alpha-steroid 4-dehydrogenase (SRD5A) DM6P8HU MT DTT DM6P8HU MA Inhibitor DM6P8HU RN Clinical pipeline report, company report or official report of GlaxoSmithKline (2009). DM6P8HU RU http://www.gsk.com/investors/product_pipeline/docs/gsk-pipeline-feb09.pdf DMM5VTA DI DMM5VTA DMM5VTA DN Dutogliptin DMM5VTA MI TTDIGC1 DMM5VTA MN Dipeptidyl peptidase 4 (DPP-4) DMM5VTA MT DTT DMM5VTA MA Inhibitor DMM5VTA RN Dutogliptin, a selective DPP4 inhibitor, improves glycaemic control in patients with type 2 diabetes: a 12-week, double-blind, randomized, placebo-controlled, multicentre trial. Diabetes Obes Metab. 2010 Apr;12(4):348-55. DMM5VTA RU https://pubmed.ncbi.nlm.nih.gov/20380656 DMAFUIR DI DMAFUIR DMAFUIR DN DWP-431 DMAFUIR MI TTP3IGX DMAFUIR MN Bone morphogenetic protein 2 (BMP2) DMAFUIR MT DTT DMAFUIR MA Modulator DMAFUIR RN Complications with the use of bone morphogenetic protein 2 (BMP-2) in spine surgery. Spine J. 2014 Mar 1;14(3):552-9. DMAFUIR RU https://pubmed.ncbi.nlm.nih.gov/24412416 DMM1YC4 DI DMM1YC4 DMM1YC4 DN E-101 DMM1YC4 MI TTVCZPI DMM1YC4 MN Myeloperoxidase (MPO) DMM1YC4 MT DTT DMM1YC4 MA Modulator DMM1YC4 RN In vitro antibacterial activity of E-101 Solution, a novel myeloperoxidase-mediated antimicrobial, against Gram-positive and Gram-negative pathogens. J Antimicrob Chemother. 2011 Feb;66(2):335-42. DMM1YC4 RU https://pubmed.ncbi.nlm.nih.gov/21118915 DMTNUJ8 DI DMTNUJ8 DMTNUJ8 DN E-2609 DMTNUJ8 MI TT8JRS7 DMTNUJ8 MN Beta-secretase (BACE) DMTNUJ8 MT DTT DMTNUJ8 MA Inhibitor DMTNUJ8 RN Targeting the beta secretase BACE1 for Alzheimer's disease therapy. Lancet Neurol. 2014 March; 13(3): 319-329. DMTNUJ8 RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4086426/ DMTNUJ8 DI DMTNUJ8 DMTNUJ8 DN E-2609 DMTNUJ8 MI TTJUNZF DMTNUJ8 MN Beta-secretase 1 (BACE1) DMTNUJ8 MT DTT DMTNUJ8 MA Inhibitor DMTNUJ8 RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMTNUJ8 RU http://phrma-docs.phrma.org/files/dmfile/MID_Neurological-Disorders-Drug-List_2018.pdf DM42PFT DI DM42PFT DM42PFT DN E-3810 DM42PFT MI TTRLW2X DM42PFT MN Fibroblast growth factor receptor 1 (FGFR1) DM42PFT MT DTT DM42PFT MA Inhibitor DM42PFT RN E-3810 is a potent dual inhibitor of VEGFR and FGFR that exerts antitumor activity in multiple preclinical models. Cancer Res. 2011 Feb 15;71(4):1396-405. DM42PFT RU https://pubmed.ncbi.nlm.nih.gov/21212416 DM42PFT DI DM42PFT DM42PFT DN E-3810 DM42PFT MI TTGJVQM DM42PFT MN Fibroblast growth factor receptor 2 (FGFR2) DM42PFT MT DTT DM42PFT MA Inhibitor DM42PFT RN E-3810 is a potent dual inhibitor of VEGFR and FGFR that exerts antitumor activity in multiple preclinical models. Cancer Res. 2011 Feb 15;71(4):1396-405. DM42PFT RU https://pubmed.ncbi.nlm.nih.gov/21212416 DM42PFT DI DM42PFT DM42PFT DN E-3810 DM42PFT MI TTST7KB DM42PFT MN Fibroblast growth factor receptor 3 (FGFR3) DM42PFT MT DTT DM42PFT MA Inhibitor DM42PFT RN E-3810 is a potent dual inhibitor of VEGFR and FGFR that exerts antitumor activity in multiple preclinical models. Cancer Res. 2011 Feb 15;71(4):1396-405. DM42PFT RU https://pubmed.ncbi.nlm.nih.gov/21212416 DM42PFT DI DM42PFT DM42PFT DN E-3810 DM42PFT MI TT8FYO9 DM42PFT MN Platelet-derived growth factor receptor alpha (PDGFRA) DM42PFT MT DTT DM42PFT MA Inhibitor DM42PFT RN E-3810 is a potent dual inhibitor of VEGFR and FGFR that exerts antitumor activity in multiple preclinical models. Cancer Res. 2011 Feb 15;71(4):1396-405. DM42PFT RU https://pubmed.ncbi.nlm.nih.gov/21212416 DM42PFT DI DM42PFT DM42PFT DN E-3810 DM42PFT MI TTI7421 DM42PFT MN Platelet-derived growth factor receptor beta (PDGFRB) DM42PFT MT DTT DM42PFT MA Inhibitor DM42PFT RN E-3810 is a potent dual inhibitor of VEGFR and FGFR that exerts antitumor activity in multiple preclinical models. Cancer Res. 2011 Feb 15;71(4):1396-405. DM42PFT RU https://pubmed.ncbi.nlm.nih.gov/21212416 DM42PFT DI DM42PFT DM42PFT DN E-3810 DM42PFT MI TT2Q6G1 DM42PFT MN Vascular endothelial growth factor receptor 1 (FLT-1) DM42PFT MT DTT DM42PFT MA Inhibitor DM42PFT RN E-3810 is a potent dual inhibitor of VEGFR and FGFR that exerts antitumor activity in multiple preclinical models. Cancer Res. 2011 Feb 15;71(4):1396-405. DM42PFT RU https://pubmed.ncbi.nlm.nih.gov/21212416 DM42PFT DI DM42PFT DM42PFT DN E-3810 DM42PFT MI TTUTJGQ DM42PFT MN Vascular endothelial growth factor receptor 2 (KDR) DM42PFT MT DTT DM42PFT MA Inhibitor DM42PFT RN E-3810 is a potent dual inhibitor of VEGFR and FGFR that exerts antitumor activity in multiple preclinical models. Cancer Res. 2011 Feb 15;71(4):1396-405. DM42PFT RU https://pubmed.ncbi.nlm.nih.gov/21212416 DM42PFT DI DM42PFT DM42PFT DN E-3810 DM42PFT MI TTDCBX5 DM42PFT MN Vascular endothelial growth factor receptor 3 (FLT-4) DM42PFT MT DTT DM42PFT MA Inhibitor DM42PFT RN E-3810 is a potent dual inhibitor of VEGFR and FGFR that exerts antitumor activity in multiple preclinical models. Cancer Res. 2011 Feb 15;71(4):1396-405. DM42PFT RU https://pubmed.ncbi.nlm.nih.gov/21212416 DMUHS5Q DI DMUHS5Q DMUHS5Q DN E-913 DMUHS5Q MI TT2CEJG DMUHS5Q MN C-C chemokine receptor type 5 (CCR5) DMUHS5Q MT DTT DMUHS5Q MA Antagonist DMUHS5Q RN Species selectivity of small-molecular antagonists for the CCR5 chemokine receptor. Int Immunopharmacol. 2007 Dec 5;7(12):1528-34. DMUHS5Q RU https://pubmed.ncbi.nlm.nih.gov/17920529 DMLA1ER DI DMLA1ER DMLA1ER DN EC20 DMLA1ER MI TTVC37M DMLA1ER MN Folate receptor alpha (FOLR1) DMLA1ER MT DTT DMLA1ER MA Modulator DMLA1ER RN EP patent application no. 2822386, Folate receptor alpha binding ligands. DMLA1ER RU http://www.google.com/patents/EP2822386A1?cl=en DMS9R43 DI DMS9R43 DMS9R43 DN Ecopipam DMS9R43 MI TTZFYLI DMS9R43 MN Dopamine D1 receptor (D1R) DMS9R43 MT DTT DMS9R43 MA Modulator DMS9R43 RN A D1 receptor antagonist, ecopipam, for treatment of tics in Tourette syndrome.Clin Neuropharmacol.2014 Jan-Feb;37(1):26-30. DMS9R43 RU https://www.ncbi.nlm.nih.gov/pubmed/24434529 DMRLXAI DI DMRLXAI DMRLXAI DN ED-71 DMRLXAI MI DE5FUD0 DMRLXAI MN Methylsterol monooxygenase 1 (MSMO1) DMRLXAI MT DME DMRLXAI MA Metabolism DMRLXAI RN Human hepatic metabolism of the anti-osteoporosis drug eldecalcitol involves sterol C4-methyl oxidase. Pharmacol Res Perspect. 2015 Mar;3(2):e00120. DMRLXAI RU https://www.ncbi.nlm.nih.gov/pubmed/?term=26038696 DMYVBF6 DI DMYVBF6 DMYVBF6 DN Edasalonexent DMYVBF6 MI TTSXVID DMYVBF6 MN Nuclear factor NF-kappa-B (NFKB) DMYVBF6 MT DTT DMYVBF6 MA Inhibitor DMYVBF6 RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMYVBF6 RU http://phrma-docs.phrma.org/files/dmfile/MID_Neurological-Disorders-Drug-List_2018.pdf DM3ZL7D DI DM3ZL7D DM3ZL7D DN Edotecarin DM3ZL7D MI DTI7UX6 DM3ZL7D MN Breast cancer resistance protein (ABCG2) DM3ZL7D MT DTP DM3ZL7D MA Substrate DM3ZL7D RN Pharmacogenomic importance of ABCG2. Pharmacogenomics. 2008 Aug;9(8):1005-9. DM3ZL7D RU https://doi.org/10.2217/14622416.9.8.1005 DM3ZL7D DI DM3ZL7D DM3ZL7D DN Edotecarin DM3ZL7D MI TTGTQHC DM3ZL7D MN DNA topoisomerase I (TOP1) DM3ZL7D MT DTT DM3ZL7D MA Inhibitor DM3ZL7D RN Edotecarin: a novel topoisomerase I inhibitor. Clin Colorectal Cancer. 2005 May;5(1):27-36. DM3ZL7D RU https://pubmed.ncbi.nlm.nih.gov/15929804 DMX7BM4 DI DMX7BM4 DMX7BM4 DN Efaproxyn DMX7BM4 MI TTQO71U DMX7BM4 MN Hemoglobin (HB) DMX7BM4 MT DTT DMX7BM4 MA Inhibitor DMX7BM4 RN Increased oxygenation of intracranial tumors by efaproxyn (efaproxiral), an allosteric hemoglobin modifier: In vivo EPR oximetry study. Int J Radiat Oncol Biol Phys. 2005 Apr 1;61(5):1503-9. DMX7BM4 RU https://pubmed.ncbi.nlm.nih.gov/15817356 DMKA2PI DI DMKA2PI DMKA2PI DN Efpeglenatide DMKA2PI MI TTVIMDE DMKA2PI MN Glucagon-like peptide 1 receptor (GLP1R) DMKA2PI MT DTT DMKA2PI MA Agonist DMKA2PI RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMKA2PI RU http://phrma-docs.phrma.org/files/dmfile/mid-diabetes-drug-list.pdf DMCMJRA DI DMCMJRA DMCMJRA DN EGF816 DMCMJRA MI TTGKNB4 DMCMJRA MN Epidermal growth factor receptor (EGFR) DMCMJRA MT DTT DMCMJRA MA Inhibitor DMCMJRA RN Discovery of a mutant-selective covalent inhibitor of EGFR that overcomes T790M-mediated resistance in NSCLC. Cancer Discov. 2013 Dec;3(12):1404-15. DMCMJRA RU https://pubmed.ncbi.nlm.nih.gov/24065731 DMB2C0E DI DMB2C0E DMB2C0E DN Elagolix DMB2C0E MI TT8R70G DMB2C0E MN Gonadotropin-releasing hormone receptor (GNRHR) DMB2C0E MT DTT DMB2C0E MA Antagonist DMB2C0E RN Elagolix, a novel, orally bioavailable GnRH antagonist under investigation for the treatment of endometriosis-related pain. Womens Health (Lond Engl). 2015 Jan;11(1):19-28. DMB2C0E RU https://pubmed.ncbi.nlm.nih.gov/25581052 DMW6C81 DI DMW6C81 DMW6C81 DN Eltoprazine DMW6C81 MI TTSQIFT DMW6C81 MN 5-HT 1A receptor (HTR1A) DMW6C81 MT DTT DMW6C81 MA Agonist DMW6C81 RN Clinical pipeline report, company report or official report of Jazz Pharmaceuticals. DMW6C81 RU http://www.jazzpharma.com/products/ DMW6C81 DI DMW6C81 DMW6C81 DN Eltoprazine DMW6C81 MI TTK8CXU DMW6C81 MN 5-HT 1B receptor (HTR1B) DMW6C81 MT DTT DMW6C81 MA Agonist DMW6C81 RN Clinical pipeline report, company report or official report of Jazz Pharmaceuticals. DMW6C81 RU http://www.jazzpharma.com/products/ DMW6C81 DI DMW6C81 DMW6C81 DN Eltoprazine DMW6C81 MI TTWJBZ5 DMW6C81 MN 5-HT 2C receptor (HTR2C) DMW6C81 MT DTT DMW6C81 MA Antagonist DMW6C81 RN Clinical pipeline report, company report or official report of Jazz Pharmaceuticals. DMW6C81 RU http://www.jazzpharma.com/products/ DMZKTYJ DI DMZKTYJ DMZKTYJ DN Enmetazobactam DMZKTYJ MI TTHI19T DMZKTYJ MN Staphylococcus Beta-lactamase (Stap-coc blaZ) DMZKTYJ MT DTT DMZKTYJ MA Inhibitor DMZKTYJ RN Pharmacodynamics of Cefepime Combined with the Novel Extended-Spectrum--Lactamase (ESBL) Inhibitor Enmetazobactam for Murine Pneumonia Caused by ESBL-Producing Klebsiella pneumoniae. Antimicrob Agents Chemother. 2020 May 21;64(6):e00180-20. DMZKTYJ RU https://pubmed.ncbi.nlm.nih.gov/32253209 DMIKDCQ DI DMIKDCQ DMIKDCQ DN Ensartinib DMIKDCQ MI TTPMQSO DMIKDCQ MN ALK tyrosine kinase receptor (ALK) DMIKDCQ MT DTT DMIKDCQ MA Inhibitor DMIKDCQ RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMIKDCQ RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DM7EOBQ DI DM7EOBQ DM7EOBQ DN Entacapone+levodopa+carbidopa DM7EOBQ MI TTKWFB8 DM7EOBQ MN Catechol-O-methyl-transferase (COMT) DM7EOBQ MT DTT DM7EOBQ MA Inhibitor DM7EOBQ RN Emerging drugs for restless legs syndrome. Expert Opin Emerg Drugs. 2005 Aug;10(3):537-52. DM7EOBQ RU https://pubmed.ncbi.nlm.nih.gov/16083328 DM7EOBQ DI DM7EOBQ DM7EOBQ DN Entacapone+levodopa+carbidopa DM7EOBQ MI TTEX248 DM7EOBQ MN Dopamine D2 receptor (D2R) DM7EOBQ MT DTT DM7EOBQ MA Agonist DM7EOBQ RN Emerging drugs for restless legs syndrome. Expert Opin Emerg Drugs. 2005 Aug;10(3):537-52. DM7EOBQ RU https://pubmed.ncbi.nlm.nih.gov/16083328 DMTWLXY DI DMTWLXY DMTWLXY DN Entresto DMTWLXY MI DE4LYSA DMTWLXY MN Cytochrome P450 3A4 (CYP3A4) DMTWLXY MT DME DMTWLXY MA Metabolism DMTWLXY RN FDA label of Sacubitril and valsartan. The 2020 official website of the U.S. Food and Drug Administration. DMTWLXY RU https://www.pharma.us.novartis.com/sites/www.pharma.us.novartis.com/files/entresto.pdf DM5H0R9 DI DM5H0R9 DM5H0R9 DN Enzastaurin DM5H0R9 MI DE4LYSA DM5H0R9 MN Cytochrome P450 3A4 (CYP3A4) DM5H0R9 MT DME DM5H0R9 MA Metabolism DM5H0R9 RN Phase I study of enzastaurin and bevacizumab in patients with advanced cancer: safety, efficacy and pharmacokinetics. Invest New Drugs. 2013 Jun;31(3):653-60. DM5H0R9 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=22766773 DM5H0R9 DI DM5H0R9 DM5H0R9 DN Enzastaurin DM5H0R9 MI TTHBTOP DM5H0R9 MN PI3-kinase gamma (PIK3CG) DM5H0R9 MT DTT DM5H0R9 MA Inhibitor DM5H0R9 RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DM5H0R9 RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DM5H0R9 DI DM5H0R9 DM5H0R9 DN Enzastaurin DM5H0R9 MI TTYPXQF DM5H0R9 MN Protein kinase C beta (PRKCB) DM5H0R9 MT DTT DM5H0R9 MA Modulator DM5H0R9 RN The oral protein-kinase C beta inhibitor enzastaurin (LY317615) suppresses signalling through the AKT pathway, inhibits proliferation and induces apoptosis in multiple myeloma cell lines. Leuk Lymphoma. 2008 Jul;49(7):1374-83. DM5H0R9 RU https://pubmed.ncbi.nlm.nih.gov/18452078 DM5H0R9 DI DM5H0R9 DM5H0R9 DN Enzastaurin DM5H0R9 MI TTWTSCV DM5H0R9 MN RAC-alpha serine/threonine-protein kinase (AKT1) DM5H0R9 MT DTT DM5H0R9 MA Inhibitor DM5H0R9 RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DM5H0R9 RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DMEX86V DI DMEX86V DMEX86V DN Epcoritamab DMEX86V MI TTUE541 DMEX86V MN Leukocyte surface antigen Leu-16 (CD20) DMEX86V MT DTT DMEX86V MA Inhibitor DMEX86V RN Clinical pipeline report, company report or official report of Genmab. DMEX86V RU https://www.genmab.com/pipeline/ DMEX86V DI DMEX86V DMEX86V DN Epcoritamab DMEX86V MI TTUN7MC DMEX86V MN T-cell surface glycoprotein CD3 (CD3) DMEX86V MT DTT DMEX86V MA Inhibitor DMEX86V RN Clinical pipeline report, company report or official report of Genmab. DMEX86V RU https://www.genmab.com/pipeline/ DM1SMAI DI DM1SMAI DM1SMAI DN Eperisone DM1SMAI MI DERSX5P DM1SMAI MN Cytochrome P450 2J2 (CYP2J2) DM1SMAI MT DME DM1SMAI MA Metabolism DM1SMAI RN Characterization of human cytochrome P450 enzymes involved in the biotransformation of eperisone. Xenobiotica. 2009 Jan;39(1):1-10. DM1SMAI RU https://www.ncbi.nlm.nih.gov/pubmed/?term=19219743 DM1SMAI DI DM1SMAI DM1SMAI DN Eperisone DM1SMAI MI DE4LYSA DM1SMAI MN Cytochrome P450 3A4 (CYP3A4) DM1SMAI MT DME DM1SMAI MA Metabolism DM1SMAI RN Characterization of human cytochrome P450 enzymes involved in the biotransformation of eperisone. Xenobiotica. 2009 Jan;39(1):1-10. DM1SMAI RU https://www.ncbi.nlm.nih.gov/pubmed/?term=19219743 DM1SMAI DI DM1SMAI DM1SMAI DN Eperisone DM1SMAI MI TTCRJKY DM1SMAI MN Voltage-gated calcium channel (Cav) DM1SMAI MT DTT DM1SMAI MA Modulator DM1SMAI RN Suppression of calcium current in a snail neurone by eperisone and its analogues. Eur J Pharmacol. 1989 Sep 22;168(3):299-305. DM1SMAI RU https://pubmed.ncbi.nlm.nih.gov/2555204 DM08XIN DI DM08XIN DM08XIN DN EPIANDROSTERONE DM08XIN MI TTKN8W0 DM08XIN MN Glucose-6-phosphate dehydrogenase (G6PD) DM08XIN MT DTT DM08XIN MA Inhibitor DM08XIN RN Inhibition of Trypanosoma brucei glucose-6-phosphate dehydrogenase by human steroids and their effects on the viability of cultured parasites. Bioorg Med Chem. 2009 Mar 15;17(6):2483-9. DM08XIN RU https://pubmed.ncbi.nlm.nih.gov/19231202 DMCGWBJ DI DMCGWBJ DMCGWBJ DN Epigallocatechin gallate DMCGWBJ MI TT7AOUD DMCGWBJ MN Fatty acid synthase (FASN) DMCGWBJ MT DTT DMCGWBJ MA Inhibitor DMCGWBJ RN Inhibition of Plasmodium falciparum fatty acid biosynthesis: evaluation of FabG, FabZ, and FabI as drug targets for flavonoids. J Med Chem. 2006 Jun 1;49(11):3345-53. DMCGWBJ RU https://pubmed.ncbi.nlm.nih.gov/16722653 DMCGWBJ DI DMCGWBJ DMCGWBJ DN Epigallocatechin gallate DMCGWBJ MI TT84ETX DMCGWBJ MN Human immunodeficiency virus Reverse transcriptase (HIV RT) DMCGWBJ MT DTT DMCGWBJ MA Inhibitor DMCGWBJ RN Simplified catechin-gallate inhibitors of HIV-1 reverse transcriptase. Bioorg Med Chem Lett. 2001 Oct 22;11(20):2763-7. DMCGWBJ RU https://pubmed.ncbi.nlm.nih.gov/11591519 DMCGWBJ DI DMCGWBJ DMCGWBJ DN Epigallocatechin gallate DMCGWBJ MI TTJ4QE7 DMCGWBJ MN Matrix metalloproteinase-14 (MMP-14) DMCGWBJ MT DTT DMCGWBJ MA Inhibitor DMCGWBJ RN Regioselective synthesis of methylated epigallocatechin gallate via nitrobenzenesulfonyl (Ns) protecting group. Bioorg Med Chem Lett. 2009 Aug 1;19(15):4171-4. DMCGWBJ RU https://pubmed.ncbi.nlm.nih.gov/19524436 DMCGWBJ DI DMCGWBJ DMCGWBJ DN Epigallocatechin gallate DMCGWBJ MI TTLM12X DMCGWBJ MN Matrix metalloproteinase-2 (MMP-2) DMCGWBJ MT DTT DMCGWBJ MA Inhibitor DMCGWBJ RN Regioselective synthesis of methylated epigallocatechin gallate via nitrobenzenesulfonyl (Ns) protecting group. Bioorg Med Chem Lett. 2009 Aug 1;19(15):4171-4. DMCGWBJ RU https://pubmed.ncbi.nlm.nih.gov/19524436 DMCGWBJ DI DMCGWBJ DMCGWBJ DN Epigallocatechin gallate DMCGWBJ MI TTPLTSQ DMCGWBJ MN Neutrophil elastase (NE) DMCGWBJ MT DTT DMCGWBJ MA Inhibitor DMCGWBJ RN Evaluation of human neutrophil elastase inhibitory effect of iridoid glycosides from Hedyotis diffusa. Bioorg Med Chem Lett. 2010 Jan 15;20(2):513-5. DMCGWBJ RU https://pubmed.ncbi.nlm.nih.gov/20004577 DMCGWBJ DI DMCGWBJ DMCGWBJ DN Epigallocatechin gallate DMCGWBJ MI TTHPFTS DMCGWBJ MN Plasmodium Beta-hydroxyacyl-ACP dehydratase (Malaria FabZ) DMCGWBJ MT DTT DMCGWBJ MA Inhibitor DMCGWBJ RN Inhibition of Plasmodium falciparum fatty acid biosynthesis: evaluation of FabG, FabZ, and FabI as drug targets for flavonoids. J Med Chem. 2006 Jun 1;49(11):3345-53. DMCGWBJ RU https://pubmed.ncbi.nlm.nih.gov/16722653 DMCGWBJ DI DMCGWBJ DMCGWBJ DN Epigallocatechin gallate DMCGWBJ MI TTNX2CS DMCGWBJ MN Plasmodium Enoyl-ACP reductase (Malaria fabI) DMCGWBJ MT DTT DMCGWBJ MA Inhibitor DMCGWBJ RN Green tea catechins potentiate triclosan binding to enoyl-ACP reductase from Plasmodium falciparum (PfENR). J Med Chem. 2007 Feb 22;50(4):765-75. DMCGWBJ RU https://pubmed.ncbi.nlm.nih.gov/17263522 DMCGWBJ DI DMCGWBJ DMCGWBJ DN Epigallocatechin gallate DMCGWBJ MI TTBE4IR DMCGWBJ MN Plasmodium Oxoacyl-[acyl-carrier protein] reductase (Malaria fabG) DMCGWBJ MT DTT DMCGWBJ MA Inhibitor DMCGWBJ RN Inhibition of Plasmodium falciparum fatty acid biosynthesis: evaluation of FabG, FabZ, and FabI as drug targets for flavonoids. J Med Chem. 2006 Jun 1;49(11):3345-53. DMCGWBJ RU https://pubmed.ncbi.nlm.nih.gov/16722653 DMCGWBJ DI DMCGWBJ DMCGWBJ DN Epigallocatechin gallate DMCGWBJ MI TTE14XG DMCGWBJ MN Squalene monooxygenase (SQLE) DMCGWBJ MT DTT DMCGWBJ MA Inhibitor DMCGWBJ RN Ellagitannins and hexahydroxydiphenoyl esters as inhibitors of vertebrate squalene epoxidase. J Nat Prod. 2001 Aug;64(8):1010-4. DMCGWBJ RU https://pubmed.ncbi.nlm.nih.gov/11520216 DM9QPOU DI DM9QPOU DM9QPOU DN Epoetin zeta DM9QPOU MI TTAUX24 DM9QPOU MN Erythropoietin Receptor (EPOR) DM9QPOU MT DTT DM9QPOU MA Modulator DM9QPOU RN Long-term safety and tolerability of epoetin zeta, administered intravenously, for maintenance treatment of renal anemia. Adv Ther. 2008 Nov;25(11):1215-28. DM9QPOU RU https://pubmed.ncbi.nlm.nih.gov/18931828 DMITJRU DI DMITJRU DMITJRU DN Epothilon DMITJRU MI TTML2WA DMITJRU MN Tubulin (TUB) DMITJRU MT DTT DMITJRU MA Stablizer DMITJRU RN Emerging drugs for ovarian cancer. Expert Opin Emerg Drugs. 2008 Sep;13(3):523-36. DMITJRU RU https://pubmed.ncbi.nlm.nih.gov/18764727 DMI1ZXV DI DMI1ZXV DMI1ZXV DN Epratuzumab DMI1ZXV MI TTM6QSK DMI1ZXV MN B-cell receptor CD22 (CD22) DMI1ZXV MT DTT DMI1ZXV RN New developments in immunosuppressive therapy for heart transplantation. Expert Opin Emerg Drugs. 2009 Mar;14(1):1-21. DMI1ZXV RU https://pubmed.ncbi.nlm.nih.gov/19265486 DM35T1O DI DM35T1O DM35T1O DN Epristeride DM35T1O MI TT2A0DR DM35T1O MN Oxo-5-alpha-steroid 4-dehydrogenase (SRD5A) DM35T1O MT DTT DM35T1O MA Inhibitor DM35T1O RN Discovery of a novel hybrid from finasteride and epristeride as 5alpha-reductase inhibitor. Bioorg Med Chem Lett. 2011 Jan 1;21(1):475-8. DM35T1O RU https://pubmed.ncbi.nlm.nih.gov/21094046 DMTV7ZM DI DMTV7ZM DMTV7ZM DN Eptastigmine DMTV7ZM MI TT1RS9F DMTV7ZM MN Acetylcholinesterase (AChE) DMTV7ZM MT DTT DMTV7ZM MA Inhibitor DMTV7ZM RN Eptastigmine: ten years of pharmacology, toxicology, pharmacokinetic, and clinical studies. CNS Drug Rev. 2001 Winter;7(4):369-86. DMTV7ZM RU https://pubmed.ncbi.nlm.nih.gov/11830755 DMTV7ZM DI DMTV7ZM DMTV7ZM DN Eptastigmine DMTV7ZM MI TTEB0GD DMTV7ZM MN Cholinesterase (BCHE) DMTV7ZM MT DTT DMTV7ZM MA Inhibitor DMTV7ZM RN Inhibition of human acetyl- and butyrylcholinesterase by novel carbamates of (-)- and (+)-tetrahydrofurobenzofuran and methanobenzodioxepine. J Med Chem. 2006 Apr 6;49(7):2174-85. DMTV7ZM RU https://pubmed.ncbi.nlm.nih.gov/16570913 DM6BU57 DI DM6BU57 DM6BU57 DN Eraxis/Vfend DM6BU57 MI TTZMS1L DM6BU57 MN Fungal Papulacandin B resistance protein 1 (Fung FKS1) DM6BU57 MT DTT DM6BU57 MA Inhibitor DM6BU57 RN Pfizer. Product Development Pipeline. March 31 2009. DM6BU57 RU http://media.pfizer.com/files/research/pipeline/2009_0331/pipeline_2009_0331.pdf DM9YI2C DI DM9YI2C DM9YI2C DN ErepoXen DM9YI2C MI TTAUX24 DM9YI2C MN Erythropoietin Receptor (EPOR) DM9YI2C MT DTT DM9YI2C MA Agonist DM9YI2C RN Combination erythropoietin-hydroxyurea therapy in sickle cell disease: experience from the National Institutes of Health and a literature review. Haematologica. 2006 Aug;91(8):1076-83. DM9YI2C RU https://pubmed.ncbi.nlm.nih.gov/16885048 DMKQZ0L DI DMKQZ0L DMKQZ0L DN ERITORAN DMKQZ0L MI TTISGCA DMKQZ0L MN Toll-like receptor 4 (TLR4) DMKQZ0L MT DTT DMKQZ0L MA Inhibitor DMKQZ0L RN Small molecule modulators of toll-like receptors. J Med Chem. 2008 Nov 13;51(21):6621-6. DMKQZ0L RU https://pubmed.ncbi.nlm.nih.gov/18828583 DMVU687 DI DMVU687 DMVU687 DN Esketamine DMVU687 MI DEPKLMQ DMVU687 MN Cytochrome P450 2B6 (CYP2B6) DMVU687 MT DME DMVU687 MA Metabolism DMVU687 RN Contribution of CYP3A4, CYP2B6, and CYP2C9 isoforms to N-demethylation of ketamine in human liver microsomes. Drug Metab Dispos. 2002 Jul;30(7):853-8. DMVU687 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=12065445 DMVU687 DI DMVU687 DMVU687 DN Esketamine DMVU687 MI DE5IED8 DMVU687 MN Cytochrome P450 2C9 (CYP2C9) DMVU687 MT DME DMVU687 MA Metabolism DMVU687 RN Contribution of CYP3A4, CYP2B6, and CYP2C9 isoforms to N-demethylation of ketamine in human liver microsomes. Drug Metab Dispos. 2002 Jul;30(7):853-8. DMVU687 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=12065445 DMVU687 DI DMVU687 DMVU687 DN Esketamine DMVU687 MI DE4LYSA DMVU687 MN Cytochrome P450 3A4 (CYP3A4) DMVU687 MT DME DMVU687 MA Metabolism DMVU687 RN Contribution of CYP3A4, CYP2B6, and CYP2C9 isoforms to N-demethylation of ketamine in human liver microsomes. Drug Metab Dispos. 2002 Jul;30(7):853-8. DMVU687 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=12065445 DMVU687 DI DMVU687 DMVU687 DN Esketamine DMVU687 MI DEGTFWK DMVU687 MN Mephenytoin 4-hydroxylase (CYP2C19) DMVU687 MT DME DMVU687 MA Metabolism DMVU687 RN Metabolism and metabolomics of ketamine: a toxicological approach. Forensic Sci Res. 2017 Feb 20;2(1):2-10. DMVU687 RU https://www.ncbi.nlm.nih.gov/pubmed/30483613 DMVU687 DI DMVU687 DMVU687 DN Esketamine DMVU687 MI TT9IK2Z DMVU687 MN N-methyl-D-aspartate receptor (NMDAR) DMVU687 MT DTT DMVU687 MA Antagonist DMVU687 RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMVU687 RU http://phrma-docs.phrma.org/files/dmfile/MID_Mental-Illness-2017-Drug-List_Final.pdf DM8RBHJ DI DM8RBHJ DM8RBHJ DN Esomeprazole magnesium + Aspirin DM8RBHJ MI TTF1QVM DM8RBHJ MN Gastric H(+)/K(+) ATPase alpha (ATP4A) DM8RBHJ MT DTT DM8RBHJ MA Inhibitor DM8RBHJ RN Clinical pipeline report, company report or official report of AstraZeneca (2009). DM8RBHJ RU http://www.astrazeneca.com/_mshost3690701/content/resources/media/investors/AZN-Q2-2009/AZN-Q2-2009-Pipeline.pdf DM4YGWA DI DM4YGWA DM4YGWA DN Esonarimod DM4YGWA MI TTGD6BY DM4YGWA MN TNF-alpha/IL-1 beta production (TNFA/IL1B produ) DM4YGWA MT DTT DM4YGWA MA Modulator DM4YGWA RN KE-758, an active metabolite of the new anti-rheumatic drug KE-298, suppresses production of tumor necrosis factor-alpha and interleukin-1 beta in THP-1, a human monocyte cell line. Drugs Exp Clin Res. 2002;28(5):197-205. DM4YGWA RU https://pubmed.ncbi.nlm.nih.gov/12635495 DMXLGED DI DMXLGED DMXLGED DN esuberaprost DMXLGED MI TTOFYT1 DMXLGED MN Prostacyclin receptor (PTGIR) DMXLGED MT DTT DMXLGED MA Agonist DMXLGED RN Specific binding of the new stable epoprostenol analogue beraprost sodium to prostacyclin receptors on human and rat platelets. Arzneimittelforschung. 1989 Apr;39(4):495-9. DMXLGED RU https://pubmed.ncbi.nlm.nih.gov/2665758 DMQHX1Y DI DMQHX1Y DMQHX1Y DN Etirinotecan pegol DMQHX1Y MI TTGTQHC DMQHX1Y MN DNA topoisomerase I (TOP1) DMQHX1Y MT DTT DMQHX1Y MA Inhibitor DMQHX1Y RN Nonclinical pharmacokinetics and activity of etirinotecan pegol (NKTR-102), a long-acting topoisomerase 1 inhibitor, in multiple cancer models. Cancer Chemother Pharmacol. 2014 Dec;74(6):1125-37. DMQHX1Y RU https://pubmed.ncbi.nlm.nih.gov/25228368 DMCDZ15 DI DMCDZ15 DMCDZ15 DN Evacetrapib DMCDZ15 MI TTFQAYR DMCDZ15 MN Cholesteryl ester transfer protein (CETP) DMCDZ15 MT DTT DMCDZ15 MA Inhibitor DMCDZ15 RN The dyslipidaemia market. Nat Rev Drug Discov. 2014 Nov;13(11):807-8. DMCDZ15 RU https://pubmed.ncbi.nlm.nih.gov/25323928 DMCDZ15 DI DMCDZ15 DMCDZ15 DN Evacetrapib DMCDZ15 MI DES5XRU DMCDZ15 MN Cytochrome P450 2C8 (CYP2C8) DMCDZ15 MT DME DMCDZ15 MA Metabolism DMCDZ15 RN Identification of cytochrome P450 enzymes involved in the metabolism of 4'-methoxy-alpha-pyrrolidinopropiophenone (MOPPP), a designer drug, in human liver microsomes. Xenobiotica. 2003 Oct;33(10):989-98. DMCDZ15 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=14555336 DMCDZ15 DI DMCDZ15 DMCDZ15 DN Evacetrapib DMCDZ15 MI DE4LYSA DMCDZ15 MN Cytochrome P450 3A4 (CYP3A4) DMCDZ15 MT DME DMCDZ15 MA Metabolism DMCDZ15 RN Identification of cytochrome P450 enzymes involved in the metabolism of 4'-methoxy-alpha-pyrrolidinopropiophenone (MOPPP), a designer drug, in human liver microsomes. Xenobiotica. 2003 Oct;33(10):989-98. DMCDZ15 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=14555336 DMG4UJ6 DI DMG4UJ6 DMG4UJ6 DN EVK-001 DMG4UJ6 MI TTWFZ1N DMG4UJ6 MN Dopamine receptor (DR) DMG4UJ6 MT DTT DMG4UJ6 MA Antagonist DMG4UJ6 RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMG4UJ6 RU http://phrma-docs.phrma.org/files/dmfile/mid-diabetes-drug-list.pdf DMLQO7F DI DMLQO7F DMLQO7F DN EVP-6124 DMLQO7F MI TTLA931 DMLQO7F MN Neuronal acetylcholine receptor alpha-7 (CHRNA7) DMLQO7F MT DTT DMLQO7F MA Modulator DMLQO7F RN Normalizing effects of EVP-6124, an alpha-7 nicotinic partial agonist, on event-related potentials and cognition: a proof of concept, randomized trial in patients with schizophrenia. J Psychiatr Pract. 2014 Jan;20(1):12-24. DMLQO7F RU https://pubmed.ncbi.nlm.nih.gov/24419307 DMCA7FN DI DMCA7FN DMCA7FN DN Exatecan DMCA7FN MI DTI7UX6 DMCA7FN MN Breast cancer resistance protein (ABCG2) DMCA7FN MT DTP DMCA7FN MA Substrate DMCA7FN RN Pharmacogenomic importance of ABCG2. Pharmacogenomics. 2008 Aug;9(8):1005-9. DMCA7FN RU https://doi.org/10.2217/14622416.9.8.1005 DMCA7FN DI DMCA7FN DMCA7FN DN Exatecan DMCA7FN MI DE4LYSA DMCA7FN MN Cytochrome P450 3A4 (CYP3A4) DMCA7FN MT DME DMCA7FN MA Metabolism DMCA7FN RN Phase I and pharmacological study of a new camptothecin derivative, exatecan mesylate (DX-8951f), infused over 30 minutes every three weeks. Clin Cancer Res. 2001 Oct;7(10):3056-64. DMCA7FN RU https://www.ncbi.nlm.nih.gov/pubmed/?term=11595695 DMCA7FN DI DMCA7FN DMCA7FN DN Exatecan DMCA7FN MI TTGTQHC DMCA7FN MN DNA topoisomerase I (TOP1) DMCA7FN MT DTT DMCA7FN MA Inhibitor DMCA7FN RN Phase I study of topoisomerase I inhibitor exatecan mesylate (DX-8951f) given as weekly 24-hour infusions three of every four weeks. Clin Cancer Res. 2001 Dec;7(12):3963-70. DMCA7FN RU https://pubmed.ncbi.nlm.nih.gov/11751488 DMBY56U DI DMBY56U DMBY56U DN EXISULIND DMBY56U MI TTJ0IQB DMBY56U MN Phosphodiesterase 5A (PDE5A) DMBY56U MT DTT DMBY56U MA Modulator DMBY56U RN Exisulind induction of apoptosis involves guanosine 3',5'-cyclic monophosphate phosphodiesterase inhibition, protein kinase G activation, and attenuated beta-catenin. Cancer Res. 2000 Jul 1;60(13):3338-42. DMBY56U RU https://pubmed.ncbi.nlm.nih.gov/10910034 DMOKT7Y DI DMOKT7Y DMOKT7Y DN FARGLITAZAR DMOKT7Y MI TTZMAO3 DMOKT7Y MN Peroxisome proliferator-activated receptor gamma (PPAR-gamma) DMOKT7Y MT DTT DMOKT7Y MA Modulator DMOKT7Y RN Rosiglitazone (BRL49653), a PPARgamma-selective agonist, causes peroxisome proliferator-like liver effects in obese mice. J Lipid Res. 1999 Jul;40(7):1177-84. DMOKT7Y RU https://www.ncbi.nlm.nih.gov/pubmed/10393202 DM83SEB DI DM83SEB DM83SEB DN Faricimab DM83SEB MI TTKLQTJ DM83SEB MN Angiopoietin-2 (ANGPT2) DM83SEB MT DTT DM83SEB RN Faricimab: an investigational agent targeting the Tie-2/angiopoietin pathway and VEGF-A for the treatment of retinal diseases. Expert Opin Investig Drugs. 2021 Mar;30(3):193-200. DM83SEB RU https://pubmed.ncbi.nlm.nih.gov/33471572 DM83SEB DI DM83SEB DM83SEB DN Faricimab DM83SEB MI TTOHSBA DM83SEB MN Vascular endothelial growth factor A (VEGFA) DM83SEB MT DTT DM83SEB RN Faricimab: an investigational agent targeting the Tie-2/angiopoietin pathway and VEGF-A for the treatment of retinal diseases. Expert Opin Investig Drugs. 2021 Mar;30(3):193-200. DM83SEB RU https://pubmed.ncbi.nlm.nih.gov/33471572 DMFLWX1 DI DMFLWX1 DMFLWX1 DN Farletuzumab DMFLWX1 MI TTVC37M DMFLWX1 MN Folate receptor alpha (FOLR1) DMFLWX1 MT DTT DMFLWX1 MA Modulator DMFLWX1 RN Farletuzumab (a monoclonal antibody against folate receptor alpha) in relapsed platinum-sensitive ovarian cancer.Gynecol Oncol.2013 Jun;129(3):452-8. DMFLWX1 RU https://www.ncbi.nlm.nih.gov/pubmed/23474348 DMTGYSO DI DMTGYSO DMTGYSO DN Fasiglifam hemihydrate DMTGYSO MI TTB8FUC DMTGYSO MN Free fatty acid receptor 1 (GPR40) DMTGYSO MT DTT DMTGYSO MA Modulator DMTGYSO RN A novel antidiabetic drug, fasiglifam/TAK-875, acts as an ago-allosteric modulator of FFAR1. PLoS One. 2013 Oct 10;8(10):e76280. DMTGYSO RU https://pubmed.ncbi.nlm.nih.gov/24130766 DM5PRLA DI DM5PRLA DM5PRLA DN Fasinumab DM5PRLA MI TTDN3LF DM5PRLA MN Nerve growth factor (NGF) DM5PRLA MT DTT DM5PRLA MA Inhibitor DM5PRLA RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DM5PRLA RU http://phrma-docs.phrma.org/files/dmfile/MID_Neurological-Disorders-Drug-List_2018.pdf DM8E51L DI DM8E51L DM8E51L DN FASORACETAM DM8E51L MI TTAN6JD DM8E51L MN Glutamate receptor AMPA (GRIA) DM8E51L MT DTT DM8E51L MA Modulator DM8E51L RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015 DM8E51L RU https://www.accessdata.fda.gov/scripts/cder/drugsatfda/ DM35GBS DI DM35GBS DM35GBS DN Favipiravir DM35GBS MI TTV1095 DM35GBS MN COVID-19 RNA-directed RNA polymerase (RdRp) DM35GBS MT DTT DM35GBS MA Inhibitor DM35GBS RN Favipiravir versus Arbidol for COVID-19: A Randomized Clinical Trial. medRxiv. Posted April 15, 2020. DM35GBS RU https://doi.org/10.1101/2020.03.17.20037432 DM0762O DI DM0762O DM0762O DN Fenfluramine DM0762O MI TT85JO3 DM0762O MN 5-HT receptor (5HTR) DM0762O MT DTT DM0762O MA Antagonist DM0762O RN Pharmacotherapy for obesity. Drugs. 2005;65(10):1391-418. DM0762O RU https://pubmed.ncbi.nlm.nih.gov/15977970 DMRD5SP DI DMRD5SP DMRD5SP DN Fenretinide DMRD5SP MI DES5XRU DMRD5SP MN Cytochrome P450 2C8 (CYP2C8) DMRD5SP MT DME DMRD5SP MA Metabolism DMRD5SP RN Characterization of the metabolism of fenretinide by human liver microsomes, cytochrome P450 enzymes and UDP-glucuronosyltransferases. Br J Pharmacol. 2011 Feb;162(4):989-99. DMRD5SP RU https://www.ncbi.nlm.nih.gov/pubmed/?term=21054342 DMRD5SP DI DMRD5SP DMRD5SP DN Fenretinide DMRD5SP MI TTOD7B3 DMRD5SP MN Retinoic acid receptor (RAR) DMRD5SP MT DTT DMRD5SP MA Modulator DMRD5SP RN National Cancer Institute Drug Dictionary (drug id 39582). DMRD5SP RU http://www.cancer.gov/publications/dictionaries/cancer-drug?cdrid=39582 DM4NX0C DI DM4NX0C DM4NX0C DN Fevipiprant DM4NX0C MI TTQDMX5 DM4NX0C MN Prostaglandin D2 receptor 2 (PTGDR2) DM4NX0C MT DTT DM4NX0C MA Antagonist DM4NX0C RN Fevipiprant in the treatment of asthma. Expert Opin Investig Drugs. 2018 Feb;27(2):199-207. DM4NX0C RU https://pubmed.ncbi.nlm.nih.gov/29363343 DM4XSQ2 DI DM4XSQ2 DM4XSQ2 DN FG-4592 DM4XSQ2 MI TTMHFRY DM4XSQ2 MN HIF-prolyl hydroxylase 1 (HPH-1) DM4XSQ2 MT DTT DM4XSQ2 MA Inhibitor DM4XSQ2 RN The latest advances in kidney diseases and related disorders. Drug News Perspect. 2007 Dec;20(10):647-54. DM4XSQ2 RU https://pubmed.ncbi.nlm.nih.gov/18301799 DM4XSQ2 DI DM4XSQ2 DM4XSQ2 DN FG-4592 DM4XSQ2 MI TT9ISBX DM4XSQ2 MN HIF-prolyl hydroxylase 2 (HPH-2) DM4XSQ2 MT DTT DM4XSQ2 MA Inhibitor DM4XSQ2 RN Crystalline forms of a prolyl hydroxylase inhibitor. US9115085. DM4XSQ2 RU http://www.freepatentsonline.com/US9115085.html DMFZ81T DI DMFZ81T DMFZ81T DN Fidanacogene elaparvovec DMFZ81T MI TTFEZ5Q DMFZ81T MN Coagulation factor IX (F9) DMFZ81T MT DTT DMFZ81T MA Replacement DMFZ81T RN Factor IX assay discrepancies in the setting of liver gene therapy using a hyperfunctional variant factor IX-Padua. J Thromb Haemost. 2021 May;19(5):1212-1218. DMFZ81T RU https://pubmed.ncbi.nlm.nih.gov/33636038 DMZL1I8 DI DMZL1I8 DMZL1I8 DN Fidarestat DMZL1I8 MI TTFBNVI DMZL1I8 MN Aldose reductase (AKR1B1) DMZL1I8 MT DTT DMZL1I8 MA Inhibitor DMZL1I8 RN Clinical efficacy of fidarestat, a novel aldose reductase inhibitor, for diabetic peripheral neuropathy: a 52-week multicenter placebo-controlled double-blind parallel group study. Diabetes Care. 2001 Oct;24(10):1776-82. DMZL1I8 RU https://pubmed.ncbi.nlm.nih.gov/11574441 DMM4FJ3 DI DMM4FJ3 DMM4FJ3 DN Finerenone DMM4FJ3 MI TT26PHO DMM4FJ3 MN Mineralocorticoid receptor (MR) DMM4FJ3 MT DTT DMM4FJ3 MA Antagonist DMM4FJ3 RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMM4FJ3 RU http://phrma-docs.phrma.org/files/dmfile/mid-diabetes-drug-list.pdf DMMQ7BY DI DMMQ7BY DMMQ7BY DN Fitusiran DMMQ7BY MI TTZ4MD5 DMMQ7BY MN SERPINC1 messenger RNA (SERPINC1 mRNA) DMMQ7BY MT DTT DMMQ7BY MA Inhibitor DMMQ7BY RN Targeting of Antithrombin in Hemophilia A or B with RNAi Therapy. N Engl J Med. 2017 Aug 31;377(9):819-828. DMMQ7BY RU https://pubmed.ncbi.nlm.nih.gov/28691885 DM6R2XF DI DM6R2XF DM6R2XF DN FKB238 DM6R2XF MI TT9HKJA DM6R2XF MN Vascular endothelial growth factor (VEGF) DM6R2XF MT DTT DM6R2XF MA Inhibitor DM6R2XF RN Clinical pipeline report, company report or official report of Fujifilm. DM6R2XF RU https://fujifilmkyowakirin-biologics.com/en/pipeline/ DMPSG4D DI DMPSG4D DMPSG4D DN Flobufen DMPSG4D MI TT2J34L DMPSG4D MN Arachidonate 5-lipoxygenase (5-LOX) DMPSG4D MT DTT DMPSG4D MA Modulator DMPSG4D RN Pharmacological profile of the novel potent antirheumatic 4-(2',4'-difluorobiphenyl-4-yl)-2-methyl-4-oxobutanoic acid. Arzneimittelforschung. 1997 May;47(5):648-52. DMPSG4D RU https://pubmed.ncbi.nlm.nih.gov/9205780 DMKL5AT DI DMKL5AT DMKL5AT DN Flurpiridaz F 18 DMKL5AT MI TTRU1NG DMKL5AT MN Mitochondrial complex I (NDUFA13) DMKL5AT MT DTT DMKL5AT MA Inhibitor DMKL5AT RN The next generation of cardiac positron emission tomography imaging agents: discovery of flurpiridaz F-18 for detection of coronary disease. Semin Nucl Med. 2011 Jul;41(4):305-13. DMKL5AT RU https://pubmed.ncbi.nlm.nih.gov/21624564 DM5S4DL DI DM5S4DL DM5S4DL DN Forigerimod DM5S4DL MI TTPVYKI DM5S4DL MN Signal transduction unspecific (ST) DM5S4DL MT DTT DM5S4DL MA Modulator DM5S4DL RN Spliceosomal peptide P140 for immunotherapy of systemic lupus erythematosus: results of an early phase II clinical trial. Arthritis Rheum. 2008 Dec;58(12):3873-83. DM5S4DL RU https://pubmed.ncbi.nlm.nih.gov/19035498 DM8L3JU DI DM8L3JU DM8L3JU DN Fosclin DM8L3JU MI TTLH4J3 DM8L3JU MN Plasmodium DOXP reductoisomerase (Malaria DXR) DM8L3JU MT DTT DM8L3JU MA Inhibitor DM8L3JU RN Fosmidomycin-clindamycin for Plasmodium falciparum Infections in African children. J Infect Dis. 2004 Mar 1;189(5):901-8. DM8L3JU RU https://pubmed.ncbi.nlm.nih.gov/14976608 DM3274D DI DM3274D DM3274D DN Fostamatinib disodium DM3274D MI TTOU65C DM3274D MN Tyrosine-protein kinase SYK (SYK) DM3274D MT DTT DM3274D MA Inhibitor DM3274D RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DM3274D RU http://phrma-docs.phrma.org/sites/default/files/pdf/medicines-in-development-drug-list-rare-diseases.pdf DM823WQ DI DM823WQ DM823WQ DN FP-1201 DM823WQ MI TT4TZ8J DM823WQ MN Interferon-beta (IFNB1) DM823WQ MT DTT DM823WQ MA Modulator DM823WQ RN The effect of intravenous interferon-beta-1a (FP-1201) on lung CD73 expression and on acute respiratory distress syndrome mortality: an open-label study.Lancet Respir Med. 2014 Feb;2(2):98-107. DM823WQ RU https://www.ncbi.nlm.nih.gov/pubmed/24503265 DMGF8MZ DI DMGF8MZ DMGF8MZ DN FPL-62064 DMGF8MZ MI TT2J34L DMGF8MZ MN Arachidonate 5-lipoxygenase (5-LOX) DMGF8MZ MT DTT DMGF8MZ MA Modulator DMGF8MZ RN FPL 62064, a topically active 5-lipoxygenase/cyclooxygenase inhibitor. Agents Actions. 1990 Jun;30(3-4):432-42. DMGF8MZ RU https://pubmed.ncbi.nlm.nih.gov/2117338 DMHOSCQ DI DMHOSCQ DMHOSCQ DN Fruquintinib DMHOSCQ MI TTVJ1D8 DMHOSCQ MN Vascular endothelial growth factor receptor (VEGFR) DMHOSCQ MT DTT DMHOSCQ MA Inhibitor DMHOSCQ RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMHOSCQ RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DMHOSCQ DI DMHOSCQ DMHOSCQ DN Fruquintinib DMHOSCQ MI TT2Q6G1 DMHOSCQ MN Vascular endothelial growth factor receptor 1 (FLT-1) DMHOSCQ MT DTT DMHOSCQ MA Inhibitor DMHOSCQ RN Discovery of fruquintinib, a potent and highly selective small molecule inhibitor of VEGFR 1, 2, 3 tyrosine kinases for cancer therapy. Cancer Biol Ther. 2014;15(12):1635-45. DMHOSCQ RU https://pubmed.ncbi.nlm.nih.gov/25482937 DMHOSCQ DI DMHOSCQ DMHOSCQ DN Fruquintinib DMHOSCQ MI TTUTJGQ DMHOSCQ MN Vascular endothelial growth factor receptor 2 (KDR) DMHOSCQ MT DTT DMHOSCQ MA Inhibitor DMHOSCQ RN Discovery of fruquintinib, a potent and highly selective small molecule inhibitor of VEGFR 1, 2, 3 tyrosine kinases for cancer therapy. Cancer Biol Ther. 2014;15(12):1635-45. DMHOSCQ RU https://pubmed.ncbi.nlm.nih.gov/25482937 DMHOSCQ DI DMHOSCQ DMHOSCQ DN Fruquintinib DMHOSCQ MI TTDCBX5 DMHOSCQ MN Vascular endothelial growth factor receptor 3 (FLT-4) DMHOSCQ MT DTT DMHOSCQ MA Inhibitor DMHOSCQ RN Discovery of fruquintinib, a potent and highly selective small molecule inhibitor of VEGFR 1, 2, 3 tyrosine kinases for cancer therapy. Cancer Biol Ther. 2014;15(12):1635-45. DMHOSCQ RU https://pubmed.ncbi.nlm.nih.gov/25482937 DM1YVLM DI DM1YVLM DM1YVLM DN FST-201 DM1YVLM MI TTYRL6O DM1YVLM MN Glucocorticoid receptor (NR3C1) DM1YVLM MT DTT DM1YVLM MA Agonist DM1YVLM RN A combination povidone-iodine 0.4%/dexamethasone 0.1% ophthalmic suspension in the treatment of adenoviral conjunctivitis. Adv Ther. 2009 Aug;26(8):776-83. DM1YVLM RU https://pubmed.ncbi.nlm.nih.gov/19756415 DMDKYVE DI DMDKYVE DMDKYVE DN FT-0624878 DMDKYVE MI DEI2XLV DMDKYVE MN Phosphoenolpyruvate carboxykinase (pckG) DMDKYVE MT DME DMDKYVE MA Metabolism DMDKYVE RN nan DMDKYVE RU nan DMF4I1V DI DMF4I1V DMF4I1V DN FT-0710230 DMF4I1V MI DECB0K3 DMF4I1V MN Cytochrome P450 2D6 (CYP2D6) DMF4I1V MT DME DMF4I1V MA Metabolism DMF4I1V RN Interpretation of opiate urine drug screens. DMF4I1V RU https://www.healthpartners.com/ucm/groups/public/@hp/@public/@ime/@content/documents/documents/cntrb_031044.pdf DMK38MV DI DMK38MV DMK38MV DN Fulranumab DMK38MV MI TTEDJN4 DMK38MV MN Low-affinity nerve growth factor receptor (NGFR) DMK38MV MT DTT DMK38MV MA Antagonist DMK38MV RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1888). DMK38MV RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1888 DMP83UZ DI DMP83UZ DMP83UZ DN Fumaric acid DMP83UZ MI TT93WF5 DMP83UZ MN Interferon-gamma (IFNG) DMP83UZ MT DTT DMP83UZ MA Binder DMP83UZ RN Emerging oral drugs for multiple sclerosis. Expert Opin Emerg Drugs. 2008 Sep;13(3):465-77. DMP83UZ RU https://pubmed.ncbi.nlm.nih.gov/18764723 DMZARP1 DI DMZARP1 DMZARP1 DN FV-100 DMZARP1 MI TTP3QRF DMZARP1 MN Thymidine kinase 1 (TK1) DMZARP1 MT DTT DMZARP1 MA Inhibitor DMZARP1 RN Specific recognition of the bicyclic pyrimidine nucleoside analogs, a new class of highly potent and selective inhibitors of varicella-zoster virus (VZV), by the VZV-encoded thymidine kinase. Mol Pharmacol. 2002 Feb;61(2):249-54. DMZARP1 RU https://pubmed.ncbi.nlm.nih.gov/11809847 DMMNP2F DI DMMNP2F DMMNP2F DN G17DT DMMNP2F MI TT4LRVO DMMNP2F MN Gastrin (GAST) DMMNP2F MT DTT DMMNP2F RN G17DT: an antigastrin immunogen for the treatment of gastrointestinal malignancy. Expert Opin Biol Ther. 2007 Mar;7(3):397-404. DMMNP2F RU https://pubmed.ncbi.nlm.nih.gov/17309331 DMXJMKF DI DMXJMKF DMXJMKF DN Ganaxolone DMXJMKF MI TTGXH6N DMXJMKF MN GABA(A) receptor delta (GABRD) DMXJMKF MT DTT DMXJMKF MA Modulator DMXJMKF RN Ganaxolone, a selective, high-affinity steroid modulator of the gamma-aminobutyric acid-A receptor, exacerbates seizures in animal models of absence. Ann Neurol. 1998 Oct;44(4):688-91. DMXJMKF RU https://www.ncbi.nlm.nih.gov/pubmed/9778270 DMXJMKF DI DMXJMKF DMXJMKF DN Ganaxolone DMXJMKF MI TTEX6LM DMXJMKF MN GABA(A) receptor gamma-3 (GABRG3) DMXJMKF MT DTT DMXJMKF MA Agonist DMXJMKF RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMXJMKF RU http://phrma-docs.phrma.org/files/dmfile/MID_Mental-Illness-2017-Drug-List_Final.pdf DMWX90U DI DMWX90U DMWX90U DN Gantenerumab DMWX90U MI TTE4KHA DMWX90U MN Amyloid beta A4 protein (APP) DMWX90U MT DTT DMWX90U RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMWX90U RU http://phrma-docs.phrma.org/files/dmfile/MID_Neurological-Disorders-Drug-List_2018.pdf DMO3ITF DI DMO3ITF DMO3ITF DN GASTRAZOLE DMO3ITF MI TTVFO0U DMO3ITF MN Gastrin/cholecystokinin type B receptor (CCKBR) DMO3ITF MT DTT DMO3ITF MA Antagonist DMO3ITF RN Gastrazole (JB95008), a novel CCK2/gastrin receptor antagonist, in the treatment of advanced pancreatic cancer: results from two randomised controlled trials. Br J Cancer. 2006 April 24; 94(8): 1107-1115. DMO3ITF RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2361246/ DMT4QHD DI DMT4QHD DMT4QHD DN GDC-0032 DMT4QHD MI TTEUNMR DMT4QHD MN PI3-kinase alpha (PIK3CA) DMT4QHD MT DTT DMT4QHD MA Modulator DMT4QHD RN Company report (BioOncology) DMT4QHD RU http://www.biooncology.com/pipeline-molecules/taselisib-gdc-0032 DMT4QHD DI DMT4QHD DMT4QHD DN GDC-0032 DMT4QHD MI TTHBTOP DMT4QHD MN PI3-kinase gamma (PIK3CG) DMT4QHD MT DTT DMT4QHD MA Inhibitor DMT4QHD RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMT4QHD RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DMWBZJD DI DMWBZJD DMWBZJD DN GDC-0068 DMWBZJD MI TTWTSCV DMWBZJD MN RAC-alpha serine/threonine-protein kinase (AKT1) DMWBZJD MT DTT DMWBZJD MA Inhibitor DMWBZJD RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMWBZJD RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DMBEL3Q DI DMBEL3Q DMBEL3Q DN GDC-0853 DMBEL3Q MI TTGM6VW DMBEL3Q MN Tyrosine-protein kinase BTK (ATK) DMBEL3Q MT DTT DMBEL3Q MA Inhibitor DMBEL3Q RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMBEL3Q RU http://phrma-docs.phrma.org/files/dmfile/medicines-in-development-drug-list-autoimmune-diseases.pdf DMTUV7L DI DMTUV7L DMTUV7L DN GED-0301 DMTUV7L MI TTW06P4 DMTUV7L MN Mothers against decapentaplegic homolog 7 (SMAD7) DMTUV7L MT DTT DMTUV7L MA Inhibitor DMTUV7L RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMTUV7L RU http://phrma-docs.phrma.org/files/dmfile/medicines-in-development-drug-list-autoimmune-diseases.pdf DMTUV7L DI DMTUV7L DMTUV7L DN GED-0301 DMTUV7L MI TT0J32Z DMTUV7L MN Smad7 messenger RNA (Smad7 mRNA) DMTUV7L MT DTT DMTUV7L MA Inhibitor DMTUV7L RN A phase 1 open-label trial shows that smad7 antisense oligonucleotide (GED0301) does not increase the risk of small bowel strictures in Crohn's disease. Aliment Pharmacol Ther. 2012 Nov;36(9):850-7. DMTUV7L RU https://pubmed.ncbi.nlm.nih.gov/22971085 DM4GWL7 DI DM4GWL7 DM4GWL7 DN Gefapixant DM4GWL7 MI TT2THBD DM4GWL7 MN P2X purinoceptor 3 (P2RX3) DM4GWL7 MT DTT DM4GWL7 MA Inhibitor DM4GWL7 RN Antibodies and venom peptides: new modalities for ion channels. Nat Rev Drug Discov. 2019 May;18(5):339-357. DM4GWL7 RU https://pubmed.ncbi.nlm.nih.gov/30728472 DMZKGPV DI DMZKGPV DMZKGPV DN Gemigliptin DMZKGPV MI TTDIGC1 DMZKGPV MN Dipeptidyl peptidase 4 (DPP-4) DMZKGPV MT DTT DMZKGPV MA Inhibitor DMZKGPV RN Evaluation of the pharmacokinetics of the DPP-4 inhibitor gemigliptin when coadministered with rosuvastatin or irbesartan to healthy subjects. Curr Med Res Opin. 2015 Feb;31(2):229-41. DMZKGPV RU https://pubmed.ncbi.nlm.nih.gov/25350224 DM1WMOK DI DM1WMOK DM1WMOK DN Generx DM1WMOK MI TTCEKVZ DM1WMOK MN Fibroblast growth factor-4 (FGF4) DM1WMOK MT DTT DM1WMOK MA Replacement DM1WMOK RN Effects of Ad5FGF-4 in patients with angina: an analysis of pooled data from the AGENT-3 and AGENT-4 trials. J Am Coll Cardiol. 2007 Sep 11;50(11):1038-46. DM1WMOK RU https://pubmed.ncbi.nlm.nih.gov/17825712 DM7ZOAE DI DM7ZOAE DM7ZOAE DN GFT-505 DM7ZOAE MI TTJ584C DM7ZOAE MN Peroxisome proliferator-activated receptor alpha (PPARA) DM7ZOAE MT DTT DM7ZOAE MA Modulator DM7ZOAE RN Dual peroxisome proliferator-activated receptor / agonist GFT505 improves hepatic and peripheral insulin sensitivity in abdominally obese subjects.Diabetes Care.2013 Oct;36(10):2923-30. DM7ZOAE RU https://www.ncbi.nlm.nih.gov/pubmed/23715754 DM7ZOAE DI DM7ZOAE DM7ZOAE DN GFT-505 DM7ZOAE MI TT2JWF6 DM7ZOAE MN Peroxisome proliferator-activated receptor delta (PPARD) DM7ZOAE MT DTT DM7ZOAE MA Modulator DM7ZOAE RN Dual peroxisome proliferator-activated receptor / agonist GFT505 improves hepatic and peripheral insulin sensitivity in abdominally obese subjects.Diabetes Care.2013 Oct;36(10):2923-30. DM7ZOAE RU https://www.ncbi.nlm.nih.gov/pubmed/23715754 DMR6YH3 DI DMR6YH3 DMR6YH3 DN GLP-1 DMR6YH3 MI TTVIMDE DMR6YH3 MN Glucagon-like peptide 1 receptor (GLP1R) DMR6YH3 MT DTT DMR6YH3 MA Modulator DMR6YH3 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 249). DMR6YH3 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=249 DMEFCTP DI DMEFCTP DMEFCTP DN Glufosfamide DMEFCTP MI TTUBNVO DMEFCTP MN DNA synthesis (DNA synth) DMEFCTP MT DTT DMEFCTP MA Inhibitor DMEFCTP RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMEFCTP RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DMEFCTP DI DMEFCTP DMEFCTP DN Glufosfamide DMEFCTP MI TTUTN1I DMEFCTP MN Human Deoxyribonucleic acid (hDNA) DMEFCTP MT DTT DMEFCTP MA Modulator DMEFCTP RN A novel alkylating agent, glufosfamide, enhances the activity of gemcitabine in vitro and in vivo. Neoplasia. 2007 Aug;9(8):625-33. DMEFCTP RU https://www.ncbi.nlm.nih.gov/pubmed/17786181 DMOUT89 DI DMOUT89 DMOUT89 DN Glutamic acid DMOUT89 MI DE8PQ7T DMOUT89 MN D-aspartate oxidase (DDO) DMOUT89 MT DME DMOUT89 MA Metabolism DMOUT89 RN Secreted d-aspartate oxidase functions in C. elegans reproduction and development. FEBS J. 2019 Jan;286(1):124-138. DMOUT89 RU https://pubmed.ncbi.nlm.nih.gov/30387556 DM8M2N3 DI DM8M2N3 DM8M2N3 DN Glycyrrhizin DM8M2N3 MI TTN7BL9 DM8M2N3 MN Corticosteroid 11-beta-dehydrogenase 1 (HSD11B1) DM8M2N3 MT DTT DM8M2N3 MA Inhibitor DM8M2N3 RN Discovery of novel dual functional agent as PPARgamma agonist and 11beta-HSD1 inhibitor for the treatment of diabetes. Bioorg Med Chem. 2009 Aug 1;17(15):5722-32. DM8M2N3 RU https://pubmed.ncbi.nlm.nih.gov/19574056 DM8M2N3 DI DM8M2N3 DM8M2N3 DN Glycyrrhizin DM8M2N3 MI DE4LYSA DM8M2N3 MN Cytochrome P450 3A4 (CYP3A4) DM8M2N3 MT DME DM8M2N3 MA Metabolism DM8M2N3 RN Effect of glycyrrhizin on the activity of CYP3A enzyme in humans. Eur J Clin Pharmacol. 2010 Aug;66(8):805-810. DM8M2N3 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=20393696 DM8M2N3 DI DM8M2N3 DM8M2N3 DN Glycyrrhizin DM8M2N3 MI DEIBDNY DM8M2N3 MN Cytochrome P450 3A5 (CYP3A5) DM8M2N3 MT DME DM8M2N3 MA Metabolism DM8M2N3 RN Effect of glycyrrhizin on the activity of CYP3A enzyme in humans. Eur J Clin Pharmacol. 2010 Aug;66(8):805-810. DM8M2N3 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=20393696 DM8M2N3 DI DM8M2N3 DM8M2N3 DN Glycyrrhizin DM8M2N3 MI DERD86B DM8M2N3 MN Cytochrome P450 3A7 (CYP3A7) DM8M2N3 MT DME DM8M2N3 MA Metabolism DM8M2N3 RN Effect of glycyrrhizin on the activity of CYP3A enzyme in humans. Eur J Clin Pharmacol. 2010 Aug;66(8):805-810. DM8M2N3 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=20393696 DM8M2N3 DI DM8M2N3 DM8M2N3 DN Glycyrrhizin DM8M2N3 MI DTFI42L DM8M2N3 MN Multidrug resistance-associated protein 2 (ABCC2) DM8M2N3 MT DTP DM8M2N3 MA Substrate DM8M2N3 RN Human intestinal transporter database: QSAR modeling and virtual profiling of drug uptake, efflux and interactions. Pharm Res. 2013 Apr;30(4):996-1007. DM8M2N3 RU https://doi.org/10.1007/s11095-012-0935-x DM8M2N3 DI DM8M2N3 DM8M2N3 DN Glycyrrhizin DM8M2N3 MI DTQ3ZHF DM8M2N3 MN Multidrug resistance-associated protein 3 (ABCC3) DM8M2N3 MT DTP DM8M2N3 MA Substrate DM8M2N3 RN The combination of glycyrrhizin and lamivudine can reverse the cisplatin resistance in hepatocellular carcinoma cells through inhibition of multidrug resistance-associated proteins. Int J Oncol. 2007 Dec;31(6):1465-72. DM8M2N3 RU http://www.spandidos-publications.com/ijo/31/6/1465 DMQCZ4N DI DMQCZ4N DMQCZ4N DN Glyminox DMQCZ4N MI TT84ETX DMQCZ4N MN Human immunodeficiency virus Reverse transcriptase (HIV RT) DMQCZ4N MT DTT DMQCZ4N MA Inhibitor DMQCZ4N RN Glyminox Biosyn. Curr Opin Investig Drugs. 2004 Feb;5(2):222-31. DMQCZ4N RU https://pubmed.ncbi.nlm.nih.gov/15043398 DMOHUR2 DI DMOHUR2 DMOHUR2 DN GLYX-13 DMOHUR2 MI TT9IK2Z DMOHUR2 MN N-methyl-D-aspartate receptor (NMDAR) DMOHUR2 MT DTT DMOHUR2 MA Agonist DMOHUR2 RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMOHUR2 RU http://phrma-docs.phrma.org/files/dmfile/MID_Mental-Illness-2017-Drug-List_Final.pdf DMQIE7U DI DMQIE7U DMQIE7U DN GMA102 DMQIE7U MI TTVIMDE DMQIE7U MN Glucagon-like peptide 1 receptor (GLP1R) DMQIE7U MT DTT DMQIE7U MA Inhibitor DMQIE7U RN Clinical pipeline report, company report or official report of Gmax Biopharm. DMQIE7U RU http://www.gmaxbiopharm.com/wap_product_detailen/id/2.html DM2XSG0 DI DM2XSG0 DM2XSG0 DN GMA105 DM2XSG0 MI TTVIMDE DM2XSG0 MN Glucagon-like peptide 1 receptor (GLP1R) DM2XSG0 MT DTT DM2XSG0 MA Inhibitor DM2XSG0 RN Clinical pipeline report, company report or official report of Gmax Biopharm. DM2XSG0 RU http://www.gmaxbiopharm.com/wap_product_detailen/id/3.html DMJ432G DI DMJ432G DMJ432G DN GMI-1070 DMJ432G MI TTAU4D6 DMJ432G MN E-selectin (SELE) DMJ432G MT DTT DMJ432G MA Inhibitor DMJ432G RN Deal watch: Pfizer deal for selectin inhibitor highlights potential of glycomimetic drugs. Nat Rev Drug Discov. 2011 Dec 1;10(12):890. DMJ432G RU https://pubmed.ncbi.nlm.nih.gov/22129980 DMJ432G DI DMJ432G DMJ432G DN GMI-1070 DMJ432G MI TT2IYXF DMJ432G MN L-selectin (SELL) DMJ432G MT DTT DMJ432G MA Inhibitor DMJ432G RN Deal watch: Pfizer deal for selectin inhibitor highlights potential of glycomimetic drugs. Nat Rev Drug Discov. 2011 Dec 1;10(12):890. DMJ432G RU https://pubmed.ncbi.nlm.nih.gov/22129980 DMJ432G DI DMJ432G DMJ432G DN GMI-1070 DMJ432G MI TTE5VG0 DMJ432G MN P-selectin (SELP) DMJ432G MT DTT DMJ432G MA Inhibitor DMJ432G RN Deal watch: Pfizer deal for selectin inhibitor highlights potential of glycomimetic drugs. Nat Rev Drug Discov. 2011 Dec 1;10(12):890. DMJ432G RU https://pubmed.ncbi.nlm.nih.gov/22129980 DMJ432G DI DMJ432G DMJ432G DN GMI-1070 DMJ432G MI TTBGONL DMJ432G MN Selectin (SEL) DMJ432G MT DTT DMJ432G MA Antagonist DMJ432G RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMJ432G RU http://phrma-docs.phrma.org/sites/default/files/pdf/medicines-in-development-drug-list-rare-diseases.pdf DMDTGWQ DI DMDTGWQ DMDTGWQ DN GMI-1271 DMDTGWQ MI TTAU4D6 DMDTGWQ MN E-selectin (SELE) DMDTGWQ MT DTT DMDTGWQ MA Inhibitor DMDTGWQ RN Clinical pipeline report, company report or official report of glycomimetics. DMDTGWQ RU http://www.glycomimetics.com/programs-pipeline/gmi-1271/ DM0LQ94 DI DM0LQ94 DM0LQ94 DN GnRH DM0LQ94 MI TT8R70G DM0LQ94 MN Gonadotropin-releasing hormone receptor (GNRHR) DM0LQ94 MT DTT DM0LQ94 MA Modulator DM0LQ94 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 256). DM0LQ94 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=256 DMKWV4B DI DMKWV4B DMKWV4B DN Golnerminogene pradenovac DMKWV4B MI TTF8CQI DMKWV4B MN Tumor necrosis factor (TNF) DMKWV4B MT DTT DMKWV4B MA Modulator DMKWV4B RN TNFerade, an adenovector carrying the transgene for human tumor necrosis factor alpha, for patients with advanced solid tumors: surgical experience... Ann Surg Oncol. 2005 Oct;12(10):825-30. DMKWV4B RU https://pubmed.ncbi.nlm.nih.gov/16132372 DMZS2R7 DI DMZS2R7 DMZS2R7 DN Granexin gel DMZS2R7 MI TT4F7SL DMZS2R7 MN Gap junction alpha-1 protein (GJA1) DMZS2R7 MT DTT DMZS2R7 MA Modulator DMZS2R7 RN Antibodies and venom peptides: new modalities for ion channels. Nat Rev Drug Discov. 2019 May;18(5):339-357. DMZS2R7 RU https://pubmed.ncbi.nlm.nih.gov/30728472 DM4Y7WV DI DM4Y7WV DM4Y7WV DN GRASPA DM4Y7WV MI TT4WT91 DM4Y7WV MN Asparaginase (ASRGL1) DM4Y7WV MT DTT DM4Y7WV MA Modulator DM4Y7WV RN l-asparaginase loaded red blood cells in refractory or relapsing acute lymphoblastic leukaemia in children and adults: results of the GRASPALL 2005-01 randomized trial. Br J Haematol. 2011 Apr;153(1):58-65. DM4Y7WV RU https://pubmed.ncbi.nlm.nih.gov/21332712 DM71GPM DI DM71GPM DM71GPM DN Grippol Plus DM71GPM MI TT3J5ZI DM71GPM MN Cell mediated immunity response (CMIR) DM71GPM MT DTT DM71GPM RN Clinical pipeline report, company report or official report of Petrovax. DM71GPM RU http://petrovax.com/medication/catalog/grippallplus/ DMB34TZ DI DMB34TZ DMB34TZ DN Grippol TC DMB34TZ MI TT3J5ZI DMB34TZ MN Cell mediated immunity response (CMIR) DMB34TZ MT DTT DMB34TZ RN Clinical pipeline report, company report or official report of Petrovax. DMB34TZ RU http://petrovax.com/medication/catalog/grippallplus/ DMHN3PG DI DMHN3PG DMHN3PG DN GRT-6005 DMHN3PG MI TTKWM86 DMHN3PG MN Opioid receptor mu (MOP) DMHN3PG MT DTT DMHN3PG MA Modulator DMHN3PG RN Cebranopadol: a first in-class example of a nociceptin/orphanin FQ receptor and opioid receptor agonist. Br J Anaesth. 2015 Mar;114(3):364-6. DMHN3PG RU https://pubmed.ncbi.nlm.nih.gov/25248647 DMNZO7M DI DMNZO7M DMNZO7M DN GS-441524 DMNZO7M MI TTS824E DMNZO7M MN COVID-19 replicase polyprotein 1ab (pp1ab) DMNZO7M MT DTT DMNZO7M MA Inhibitor DMNZO7M RN Current knowledge about the antivirals remdesivir (GS-5734) and GS-441524 as therapeutic options for coronaviruses. One Health. 2020 Mar 27;9:100128. DMNZO7M RU https://pubmed.ncbi.nlm.nih.gov/32258351 DMP8MDW DI DMP8MDW DMP8MDW DN GS-5745 DMP8MDW MI TT6X50U DMP8MDW MN Matrix metalloproteinase-9 (MMP-9) DMP8MDW MT DTT DMP8MDW MA Modulator DMP8MDW RN National Cancer Institute Drug Dictionary (drug id 747683). DMP8MDW RU http://www.cancer.gov/publications/dictionaries/cancer-drug?cdrid=747683 DMGJQVI DI DMGJQVI DMGJQVI DN GS-6615 DMGJQVI MI TT40BO8 DMGJQVI MN Late inward sodium current (LISC) DMGJQVI MT DTT DMGJQVI MA Modulator DMGJQVI RN Clinical pipeline report, company report or official report of Gilead. DMGJQVI RU http://www.gilead.com/news/press-releases/2014/5/gilead-announces-phase-1-data-for-investigational-therapy-gs6615-in-patients-with-long-qt3-syndrome DM936V7 DI DM936V7 DM936V7 DN GS-9674 DM936V7 MI TTS4UGC DM936V7 MN Farnesoid X-activated receptor (FXR) DM936V7 MT DTT DM936V7 MA Agonist DM936V7 RN The Nonsteroidal Farnesoid X Receptor Agonist Cilofexor (GS-9674) Improves Markers of Cholestasis and Liver Injury in Patients With Primary Sclerosing Cholangitis. Hepatology. 2019 Sep;70(3):788-801. DM936V7 RU https://pubmed.ncbi.nlm.nih.gov/30661255 DMT8J0I DI DMT8J0I DMT8J0I DN GSK1265744 DMT8J0I MI TT5FH9Y DMT8J0I MN Human immunodeficiency virus Integrase (HIV IN) DMT8J0I MT DTT DMT8J0I MA Inhibitor DMT8J0I RN Clinical pipeline report, company report or official report of GlaxoSmithKline (2009). DMT8J0I RU http://www.gsk.com/investors/product_pipeline/docs/gsk-pipeline-feb09.pdf DMT8J0I DI DMT8J0I DMT8J0I DN GSK1265744 DMT8J0I MI DEYGVN4 DMT8J0I MN UDP-glucuronosyltransferase 1A1 (UGT1A1) DMT8J0I MT DME DMT8J0I MA Metabolism DMT8J0I RN Disposition and metabolism of cabotegravir: a comparison of biotransformation and excretion between different species and routes of administration in humans. Xenobiotica. 2016;46(2):147-62. DMT8J0I RU https://www.ncbi.nlm.nih.gov/pubmed/?term=26134155 DMT8J0I DI DMT8J0I DMT8J0I DN GSK1265744 DMT8J0I MI DE85D2P DMT8J0I MN UDP-glucuronosyltransferase 1A9 (UGT1A9) DMT8J0I MT DME DMT8J0I MA Metabolism DMT8J0I RN Disposition and metabolism of cabotegravir: a comparison of biotransformation and excretion between different species and routes of administration in humans. Xenobiotica. 2016;46(2):147-62. DMT8J0I RU https://www.ncbi.nlm.nih.gov/pubmed/?term=26134155 DMRNGD2 DI DMRNGD2 DMRNGD2 DN GSK1278863 DMRNGD2 MI DES5XRU DMRNGD2 MN Cytochrome P450 2C8 (CYP2C8) DMRNGD2 MT DME DMRNGD2 MA Metabolism DMRNGD2 RN Pharmacokinetics, pharmacodynamics and safety of single, oral doses of GSK1278863, a novel HIF-prolyl hydroxylase inhibitor, in healthy Japanese and Caucasian subjects. Drug Metab Pharmacokinet. 2015 Dec;30(6):410-8. DMRNGD2 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=26643993 DMRNGD2 DI DMRNGD2 DMRNGD2 DN GSK1278863 DMRNGD2 MI TTMHFRY DMRNGD2 MN HIF-prolyl hydroxylase 1 (HPH-1) DMRNGD2 MT DTT DMRNGD2 MA Inhibitor DMRNGD2 RN Clinical pipeline report, company report or official report of GlaxoSmithKline (2009). DMRNGD2 RU http://www.gsk.com/investors/product_pipeline/docs/gsk-pipeline-feb09.pdf DMSMFN2 DI DMSMFN2 DMSMFN2 DN GSK2140944 DMSMFN2 MI TT0IHXV DMSMFN2 MN DNA topoisomerase II (TOP2) DMSMFN2 MT DTT DMSMFN2 MA Inhibitor DMSMFN2 RN Determination of disk diffusion and MIC quality control guidelines for GSK2140944, a novel bacterial type II topoisomerase inhibitor antimicrobial agent. J Clin Microbiol. 2014 Jul;52(7):2629-32. DMSMFN2 RU https://pubmed.ncbi.nlm.nih.gov/24759716 DMWL2XD DI DMWL2XD DMWL2XD DN GSK2402968 DMWL2XD MI TTWLFXU DMWL2XD MN Dystrophin messenger RNA (DMD mRNA) DMWL2XD MT DTT DMWL2XD MA Modulator DMWL2XD RN Safety and efficacy of drisapersen for the treatment of Duchenne muscular dystrophy (DEMAND II): an exploratory, randomised, placebo-controlled phase 2 study. Lancet Neurol. 2014 Oct;13(10):987-96. DMWL2XD RU https://pubmed.ncbi.nlm.nih.gov/25209738 DMUVZAO DI DMUVZAO DMUVZAO DN GSK642444 DMUVZAO MI TT2CJVK DMUVZAO MN Adrenergic receptor beta-2 (ADRB2) DMUVZAO MT DTT DMUVZAO MA Agonist DMUVZAO RN Radium 223 dichloride for prostate cancer treatment. Drug Des Devel Ther. 2017 Sep 6;11:2643-2651. DMUVZAO RU https://pubmed.ncbi.nlm.nih.gov/28919714 DMPS7U2 DI DMPS7U2 DMPS7U2 DN GTPL-9088 DMPS7U2 MI DE4LYSA DMPS7U2 MN Cytochrome P450 3A4 (CYP3A4) DMPS7U2 MT DME DMPS7U2 MA Metabolism DMPS7U2 RN Product Information of Eumovate. DMPS7U2 RU https://www.medsafe.govt.nz/Profs/Datasheet/e/Eumovatecrm.pdf DM9Y3EG DI DM9Y3EG DM9Y3EG DN Guadecitabine DM9Y3EG MI TT6S2FE DM9Y3EG MN DNA [cytosine-5]-methyltransferase 1 (DNMT1) DM9Y3EG MT DTT DM9Y3EG MA Inhibitor DM9Y3EG RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DM9Y3EG RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DMN4E7T DI DMN4E7T DMN4E7T DN Guaiacol DMN4E7T MI TTANPDJ DMN4E7T MN Carbonic anhydrase II (CA-II) DMN4E7T MT DTT DMN4E7T MA Inhibitor DMN4E7T RN Carbonic anhydrase inhibitors. Inhibition of human erythrocyte isozymes I and II with a series of antioxidant phenols. Bioorg Med Chem. 2009 Apr 15;17(8):3207-11. DMN4E7T RU https://pubmed.ncbi.nlm.nih.gov/19231207 DMN4E7T DI DMN4E7T DMN4E7T DN Guaiacol DMN4E7T MI DEXL6TZ DMN4E7T MN Thyroid peroxidase (TPO) DMN4E7T MT DME DMN4E7T MA Metabolism DMN4E7T RN Kinetic characterization of human thyroperoxidase. Normal and pathological enzyme expression in Baculovirus system: a molecular model of functional expression. Mol Cell Endocrinol. 2015 Mar 15;404:9-15. DMN4E7T RU https://www.ncbi.nlm.nih.gov/pubmed/?term=25576858 DMIWLJE DI DMIWLJE DMIWLJE DN Guanine DMIWLJE MI TTLSWP6 DMIWLJE MN GTP cyclohydrolase-I (GCH1) DMIWLJE MT DTT DMIWLJE MA Inhibitor DMIWLJE RN GTP cyclohydrolase I feedback regulatory protein-dependent and -independent inhibitors of GTP cyclohydrolase I. Arch Biochem Biophys. 2001 Apr 1;388(1):67-73. DMIWLJE RU https://pubmed.ncbi.nlm.nih.gov/11361142 DMHULRK DI DMHULRK DMHULRK DN GV1001 DMHULRK MI TTUJFD0 DMHULRK MN Telomerase reverse transcriptase (TERT) DMHULRK MT DTT DMHULRK RN Telomerase peptide vaccination of patients with non-resectable pancreatic cancer: A dose escalating phase I/II study. Br J Cancer. 2006 Dec 4;95(11):1474-82. DMHULRK RU https://pubmed.ncbi.nlm.nih.gov/17060934 DMAXTFO DI DMAXTFO DMAXTFO DN H1N1 influenza vaccine DMAXTFO MI TT3J5ZI DMAXTFO MN Cell mediated immunity response (CMIR) DMAXTFO MT DTT DMAXTFO RN Clinical pipeline report, company report or official report of Sanofi Pasteur. DMAXTFO RU http://www.sanofipasteur.com/en/articles/sanofi-pasteur-s-a-h1n1-vaccine-humenza-recommended-by-european-medicines-agency.aspx DM9CMI3 DI DM9CMI3 DM9CMI3 DN H5N1 influenza vaccine DM9CMI3 MI TT3J5ZI DM9CMI3 MN Cell mediated immunity response (CMIR) DM9CMI3 MT DTT DM9CMI3 RN Characterization of a whole, inactivated influenza (H5N1) vaccine. Influenza and Other Respiratory Viruses Volume 2, Issue 6, pages 261-266, November 2008. DM9CMI3 RU http://onlinelibrary.wiley.com/doi/10.1111/j.1750-2659.2008.00066.x/full DMQ38JZ DI DMQ38JZ DMQ38JZ DN HB-AS02V DMQ38JZ MI TT3J5ZI DMQ38JZ MN Cell mediated immunity response (CMIR) DMQ38JZ MT DTT DMQ38JZ RN Safety and immunogenicity of an investigational adjuvanted hepatitis B vaccine (HB-AS02V) in healthy adults. Hum Vaccin. 2010 Jul;6(7):578-84. DMQ38JZ RU https://pubmed.ncbi.nlm.nih.gov/20523113 DMB06MU DI DMB06MU DMB06MU DN HC-1119 DMB06MU MI TTS64P2 DMB06MU MN Androgen receptor (AR) DMB06MU MT DTT DMB06MU MA Inhibitor DMB06MU RN Clinical pipeline report, company report or official report of Hinova Pharmaceuticals. DMB06MU RU http://www.hinovapharma.com/en/chanpinxianguan.html DMB9U5E DI DMB9U5E DMB9U5E DN HE3286 DMB9U5E MI DE4LYSA DMB9U5E MN Cytochrome P450 3A4 (CYP3A4) DMB9U5E MT DME DMB9U5E MA Metabolism DMB9U5E RN Studies of the pharmacology of 17alpha-ethynyl-androst-5-ene-3beta,7beta,17beta-triol, a synthetic anti-inflammatory androstene. Int J Clin Exp Med. 2011;4(2):119-35. DMB9U5E RU https://www.ncbi.nlm.nih.gov/pubmed/?term=21686136 DMQTLVB DI DMQTLVB DMQTLVB DN Hebergel DMQTLVB MI TTSIUJ9 DMQTLVB MN Interferon-alpha 2 (IFNA2) DMQTLVB MT DTT DMQTLVB MA Modulator DMQTLVB RN Evaluation of recombinant human interferon alpha-2b structure and stability by in-gel tryptic digestion, H/D exchange and mass spectrometry. J Pharm Biomed Anal. 2006 Feb 24;40(3):781-7. DMQTLVB RU https://pubmed.ncbi.nlm.nih.gov/16316735 DMUE843 DI DMUE843 DMUE843 DN Hematide DMUE843 MI TTAUX24 DMUE843 MN Erythropoietin Receptor (EPOR) DMUE843 MT DTT DMUE843 MA Agonist DMUE843 RN Nat Rev Drug Discov. 2013 Feb;12(2):87-90. DMUE843 RU https://pubmed.ncbi.nlm.nih.gov/23370234 DMGFULM DI DMGFULM DMGFULM DN Heparin low molecular weight DMGFULM MI TT4QPUL DMGFULM MN Antithrombin-III (ATIII) DMGFULM MT DTT DMGFULM MA Modulator DMGFULM RN Effects of low molecular weight heparin on a severely antithrombin III-decreased disseminated intravascular coagulation model in rabbits. Thromb Res. 1995 Dec 1;80(5):391-8. DMGFULM RU https://pubmed.ncbi.nlm.nih.gov/8588200 DMXAZ47 DI DMXAZ47 DMXAZ47 DN HGH-CTP DMXAZ47 MI TTT3YKH DMXAZ47 MN Somatotropin (GH1) DMXAZ47 MT DTT DMXAZ47 MA Agonist DMXAZ47 RN Developments in human growth hormone preparations: sustained-release, prolonged half-life, novel injection devices, and alternative delivery routes. Int J Nanomedicine. 2014; 9: 3527-3538. DMXAZ47 RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4122423/ DM6QOVN DI DM6QOVN DM6QOVN DN HKI-272 DM6QOVN MI DE4LYSA DM6QOVN MN Cytochrome P450 3A4 (CYP3A4) DM6QOVN MT DME DM6QOVN MA Metabolism DM6QOVN RN Pharmacodynamics, pharmacokinetics and clinical efficacy of neratinib in HER2-positive breast cancer and breast cancer with HER2 mutations. Expert Opin Drug Metab Toxicol. 2016 Aug;12(8):947-57. DM6QOVN RU https://www.ncbi.nlm.nih.gov/pubmed/?term=27284682 DM6QOVN DI DM6QOVN DM6QOVN DN HKI-272 DM6QOVN MI TTGKNB4 DM6QOVN MN Epidermal growth factor receptor (EGFR) DM6QOVN MT DTT DM6QOVN MA Inhibitor DM6QOVN RN Dual irreversible kinase inhibitors: quinazoline-based inhibitors incorporating two independent reactive centers with each targeting different cyst... Bioorg Med Chem. 2007 Jun 1;15(11):3635-48. DM6QOVN RU https://pubmed.ncbi.nlm.nih.gov/17416531 DM6QOVN DI DM6QOVN DM6QOVN DN HKI-272 DM6QOVN MI TTR5TV4 DM6QOVN MN ERBB2 messenger RNA (HER2 mRNA) DM6QOVN MT DTT DM6QOVN MA Inhibitor DM6QOVN RN Identification of genotype-correlated sensitivity to selective kinase inhibitors by using high-throughput tumor cell line profiling. Proc Natl Acad Sci U S A. 2007 Dec 11;104(50):19936-41. DM6QOVN RU https://pubmed.ncbi.nlm.nih.gov/18077425 DM6QOVN DI DM6QOVN DM6QOVN DN HKI-272 DM6QOVN MI TT6EO5L DM6QOVN MN Erbb2 tyrosine kinase receptor (HER2) DM6QOVN MT DTT DM6QOVN MA Inhibitor DM6QOVN RN A comparison of physicochemical property profiles of marketed oral drugs and orally bioavailable anti-cancer protein kinase inhibitors in clinical development. Curr Top Med Chem. 2007;7(14):1408-22. DM6QOVN RU https://pubmed.ncbi.nlm.nih.gov/17692029 DM6QOVN DI DM6QOVN DM6QOVN DN HKI-272 DM6QOVN MI TTUTJGQ DM6QOVN MN Vascular endothelial growth factor receptor 2 (KDR) DM6QOVN MT DTT DM6QOVN MA Inhibitor DM6QOVN RN Dual irreversible kinase inhibitors: quinazoline-based inhibitors incorporating two independent reactive centers with each targeting different cyst... Bioorg Med Chem. 2007 Jun 1;15(11):3635-48. DM6QOVN RU https://pubmed.ncbi.nlm.nih.gov/17416531 DM29XGY DI DM29XGY DM29XGY DN HMPL-004 DM29XGY MI TTBD054 DM29XGY MN Inflammation pathogenesis (IP) DM29XGY MT DTT DM29XGY MA Antagonist DM29XGY RN Clinical pipeline report, company report or official report of Hutchison Medi Pharma. DM29XGY RU http://www.hmplglobal.com/en/hmpl-004/ DMAVIPZ DI DMAVIPZ DMAVIPZ DN HSR-803 DMAVIPZ MI DEP76YL DMAVIPZ MN Dimethylaniline oxidase 3 (FMO3) DMAVIPZ MT DME DMAVIPZ MA Metabolism DMAVIPZ RN Development of a physiologically based pharmacokinetic model to predict the effects of flavin-containing monooxygenase 3 (FMO3) polymorphisms on itopride exposure. Biopharm Drug Dispos. 2017 Sep;38(6):389-393. DMAVIPZ RU https://www.ncbi.nlm.nih.gov/pubmed/?term=28255999 DMBER0Q DI DMBER0Q DMBER0Q DN Hu5F9-G4 DMBER0Q MI TT28S46 DMBER0Q MN Leukocyte surface antigen CD47 (CD47) DMBER0Q MT DTT DMBER0Q MA Inhibitor DMBER0Q RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMBER0Q RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DMXZAL2 DI DMXZAL2 DMXZAL2 DN Hydroxychloroquine DMXZAL2 MI TTZGK1R DMXZAL2 MN HUMAN glycosylation of host receptor (GHR) DMXZAL2 MT DTT DMXZAL2 MA Inhibitor DMXZAL2 RN Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro. Cell Res. 2020 Mar;30(3):269-271. DMXZAL2 RU https://pubmed.ncbi.nlm.nih.gov/32020029 DMXZAL2 DI DMXZAL2 DMXZAL2 DN Hydroxychloroquine DMXZAL2 MI TTD16BI DMXZAL2 MN HUMAN pH-dependent viral fusion/replication (pH-DVF/R) DMXZAL2 MT DTT DMXZAL2 MA Inhibitor DMXZAL2 RN Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro. Cell Res. 2020 Mar;30(3):269-271. DMXZAL2 RU https://pubmed.ncbi.nlm.nih.gov/32020029 DMXZAL2 DI DMXZAL2 DMXZAL2 DN Hydroxychloroquine DMXZAL2 MI TT3A1EZ DMXZAL2 MN HUMAN toll-like receptor 7/9 signalling pathway (TLR7/9 pathway) DMXZAL2 MT DTT DMXZAL2 MA Inhibitor DMXZAL2 RN Mechanisms of action of hydroxychloroquine and chloroquine: implications for rheumatology. Nat Rev Rheumatol. 2020 Mar;16(3):155-166. DMXZAL2 RU https://pubmed.ncbi.nlm.nih.gov/32034323 DMIGFOR DI DMIGFOR DMIGFOR DN I3C DMIGFOR MI TTSHAEB DMIGFOR MN NF-kappa-B inhibitor alpha (NFKBIA) DMIGFOR MT DTT DMIGFOR MA Inhibitor DMIGFOR RN Protective effect of Indole-3-carbinol, an NF-B inhibitor in experimental paradigm of Parkinson's disease: In silico and in vivo studies. Brain Behav Immun. 2020 Nov;90:108-137. DMIGFOR RU https://pubmed.ncbi.nlm.nih.gov/32800927 DM5KL8E DI DM5KL8E DM5KL8E DN IBI-308 DM5KL8E MI TTNBFWK DM5KL8E MN Programmed cell death protein 1 (PD-1) DM5KL8E MT DTT DM5KL8E RN Development of Inhibitors of the Programmed Cell Death-1/Programmed Cell Death-Ligand 1 Signaling Pathway.J Med Chem. 2019 Feb 28;62(4):1715-1730. DM5KL8E RU https://pubmed.ncbi.nlm.nih.gov/30247903 DM9G5XD DI DM9G5XD DM9G5XD DN IB-MECA DM9G5XD MI TTJFY5U DM9G5XD MN Adenosine A3 receptor (ADORA3) DM9G5XD MT DTT DM9G5XD MA Agonist DM9G5XD RN A role for central A3-adenosine receptors. Mediation of behavioral depressant effects. FEBS Lett. 1993 Dec 20;336(1):57-60. DM9G5XD RU https://pubmed.ncbi.nlm.nih.gov/8262217 DMT67EH DI DMT67EH DMT67EH DN Ibodutant DMT67EH MI TTYO0A3 DMT67EH MN Substance-K receptor (TACR2) DMT67EH MT DTT DMT67EH MA Antagonist DMT67EH RN Antagonist profile of ibodutant at the tachykinin NK2 receptor in guinea pig isolated bronchi. Eur J Pharmacol. 2013 Nov 15;720(1-3):180-5. DMT67EH RU https://pubmed.ncbi.nlm.nih.gov/24436990 DMOJQGT DI DMOJQGT DMOJQGT DN ICARIIN DMOJQGT MI TTJ0IQB DMOJQGT MN Phosphodiesterase 5A (PDE5A) DMOJQGT MT DTT DMOJQGT MA Inhibitor DMOJQGT RN Potent inhibition of human phosphodiesterase-5 by icariin derivatives. J Nat Prod. 2008 Sep;71(9):1513-7. DMOJQGT RU https://pubmed.ncbi.nlm.nih.gov/18778098 DM3OU54 DI DM3OU54 DM3OU54 DN ICI 118,551 DM3OU54 MI TT2CJVK DM3OU54 MN Adrenergic receptor beta-2 (ADRB2) DM3OU54 MT DTT DM3OU54 MA Antagonist DM3OU54 RN Selective beta 2-adrenoceptor antagonists: derivatives of ICI 118,551 and a binary aryloxypropanolamine. J Pharm Pharmacol. 1988 Nov;40(11):803-5. DM3OU54 RU https://pubmed.ncbi.nlm.nih.gov/2907563 DM7YNV9 DI DM7YNV9 DM7YNV9 DN Iclaprim DM7YNV9 MI TTV8DM2 DM7YNV9 MN Bacterial Dihydrofolate reductase (Bact DHFR) DM7YNV9 MT DTT DM7YNV9 MA Modulator DM7YNV9 RN Iclaprim: a novel dihydrofolate reductase inhibitor for skin and soft tissue infections.Future Microbiol.2009 Mar;4(2):131-44. DM7YNV9 RU https://www.ncbi.nlm.nih.gov/pubmed/19257839 DM7YNV9 DI DM7YNV9 DM7YNV9 DN Iclaprim DM7YNV9 MI DE5IED8 DM7YNV9 MN Cytochrome P450 2C9 (CYP2C9) DM7YNV9 MT DME DM7YNV9 MA Metabolism DM7YNV9 RN An updated review of iclaprim: a potent and rapidly bactericidal antibiotic for the treatment of skin and skin structure infections and nosocomial pneumonia caused by gram-positive including multidrug-resistant bacteria. Open Forum Infect Dis. 2018 Jan 6;5(2):ofy003. DM7YNV9 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=29423421 DM7YNV9 DI DM7YNV9 DM7YNV9 DN Iclaprim DM7YNV9 MI DECB0K3 DM7YNV9 MN Cytochrome P450 2D6 (CYP2D6) DM7YNV9 MT DME DM7YNV9 MA Metabolism DM7YNV9 RN An updated review of iclaprim: a potent and rapidly bactericidal antibiotic for the treatment of skin and skin structure infections and nosocomial pneumonia caused by gram-positive including multidrug-resistant bacteria. Open Forum Infect Dis. 2018 Jan 6;5(2):ofy003. DM7YNV9 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=29423421 DM7YNV9 DI DM7YNV9 DM7YNV9 DN Iclaprim DM7YNV9 MI DE4LYSA DM7YNV9 MN Cytochrome P450 3A4 (CYP3A4) DM7YNV9 MT DME DM7YNV9 MA Metabolism DM7YNV9 RN An updated review of iclaprim: a potent and rapidly bactericidal antibiotic for the treatment of skin and skin structure infections and nosocomial pneumonia caused by gram-positive including multidrug-resistant bacteria. Open Forum Infect Dis. 2018 Jan 6;5(2):ofy003. DM7YNV9 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=29423421 DM7YNV9 DI DM7YNV9 DM7YNV9 DN Iclaprim DM7YNV9 MI TTYZVDJ DM7YNV9 MN Dihydrofolate reductase (DHFR) DM7YNV9 MT DTT DM7YNV9 MA Inhibitor DM7YNV9 RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DM7YNV9 RU http://phrma-docs.phrma.org/files/dmfile/MID_Skin_Diseases_2018_9_FINAL.pdf DM7YNV9 DI DM7YNV9 DM7YNV9 DN Iclaprim DM7YNV9 MI TT9B4N3 DM7YNV9 MN Prostaglandin receptor (PTGR) DM7YNV9 MT DTT DM7YNV9 MA Modulator DM7YNV9 RN Novel ocular antihypertensive compounds in clinical trials. Clin Ophthalmol. 2011; 5: 667-677. DM7YNV9 RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3104796/ DMU72KL DI DMU72KL DMU72KL DN ICP-022 DMU72KL MI TTGM6VW DMU72KL MN Tyrosine-protein kinase BTK (ATK) DMU72KL MT DTT DMU72KL MA Inhibitor DMU72KL RN Clinical pipeline report, company report or official report of InnoCare Pharma. DMU72KL RU https://www.innocarepharma.com/en/pipeline/our-pipeline/ DMBIZ7H DI DMBIZ7H DMBIZ7H DN ICT-107 DMBIZ7H MI TTMPZ7V DMBIZ7H MN Interleukin 13 receptor alpha-2 (IL13RA2) DMBIZ7H MT DTT DMBIZ7H RN Clinical pipeline report, company report or official report of ImmunoCellular Therapeutics. DMBIZ7H RU http://www.imuc.com/pipeline/ict-107 DMSP0X8 DI DMSP0X8 DMSP0X8 DN IDAZOXAN HYDROCHLORIDE DMSP0X8 MI TT2NUT5 DMSP0X8 MN Adrenergic receptor alpha-2C (ADRA2C) DMSP0X8 MT DTT DMSP0X8 MA Modulator DMSP0X8 RN Different sites of action for alpha 2-adrenoceptor antagonists in the modulation of noradrenaline release and contraction response in the vas deferens of the rat. J Pharm Pharmacol. 1992 Mar;44(3):231-4. DMSP0X8 RU https://pubmed.ncbi.nlm.nih.gov/1354730 DMV3DHQ DI DMV3DHQ DMV3DHQ DN IDDBCP161883 DMV3DHQ MI TTDIGC1 DMV3DHQ MN Dipeptidyl peptidase 4 (DPP-4) DMV3DHQ MT DTT DMV3DHQ MA Inhibitor DMV3DHQ RN Teneligliptin: a DPP-4 inhibitor for the treatment of type 2 diabetes. Diabetes Metab Syndr Obes. 2013 May 6;6:187-95. DMV3DHQ RU https://pubmed.ncbi.nlm.nih.gov/23671395 DM3A701 DI DM3A701 DM3A701 DN IDP-122 DM3A701 MI TTP3UTW DM3A701 MN Steroid hormone receptor ERR (ESRR) DM3A701 MT DTT DM3A701 MA Agonist DM3A701 RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DM3A701 RU http://phrma-docs.phrma.org/files/dmfile/medicines-in-development-drug-list-autoimmune-diseases.pdf DMRLVUD DI DMRLVUD DMRLVUD DN Imagabalin DMRLVUD MI TTFK1JQ DMRLVUD MN Voltage-gated calcium channel alpha-2/delta-1 (CACNA2D1) DMRLVUD MT DTT DMRLVUD MA Agonist DMRLVUD RN Methodology for rapid measures of glutamate release in rat brain slices using ceramic-based microelectrode arrays: basic characterization and drug pharmacology. Brain Res. 2011 Jul 15;1401:1-9. DMRLVUD RU https://pubmed.ncbi.nlm.nih.gov/21664606 DMM9JEF DI DMM9JEF DMM9JEF DN Imatinib DMM9JEF MI TTE63HY DMM9JEF MN HUMAN fusion protein Bcr-Abl (Bcr-Abl) DMM9JEF MT DTT DMM9JEF MA Inhibitor DMM9JEF RN Coronaviruses - drug discovery and therapeutic options. Nat Rev Drug Discov. 2016 May;15(5):327-47. DMM9JEF RU https://pubmed.ncbi.nlm.nih.gov/26868298 DM7BCWT DI DM7BCWT DM7BCWT DN Imiglitazar DM7BCWT MI TTJ584C DM7BCWT MN Peroxisome proliferator-activated receptor alpha (PPARA) DM7BCWT MT DTT DM7BCWT MA Modulator DM7BCWT RN A novel oxyiminoalkanoic acid derivative, TAK-559, activates human peroxisome proliferator-activated receptor subtypes. Eur J Pharmacol. 2004 Jul 8;495(1):17-26. DM7BCWT RU https://pubmed.ncbi.nlm.nih.gov/15219816 DM7BCWT DI DM7BCWT DM7BCWT DN Imiglitazar DM7BCWT MI TTZMAO3 DM7BCWT MN Peroxisome proliferator-activated receptor gamma (PPAR-gamma) DM7BCWT MT DTT DM7BCWT MA Modulator DM7BCWT RN A novel oxyiminoalkanoic acid derivative, TAK-559, activates human peroxisome proliferator-activated receptor subtypes. Eur J Pharmacol. 2004 Jul 8;495(1):17-26. DM7BCWT RU https://pubmed.ncbi.nlm.nih.gov/15219816 DM735FA DI DM735FA DM735FA DN IMO-2125 DM735FA MI TTSHG0T DM735FA MN Toll-like receptor 9 (TLR9) DM735FA MT DTT DM735FA MA Agonist DM735FA RN Clinical pipeline report, company report or official report of Idera Pharmaceuticals (2011). DM735FA RU http://www.iderapharma.com/ DMIJGT9 DI DMIJGT9 DMIJGT9 DN INCB24360 DMIJGT9 MI TTZJYKH DMIJGT9 MN Indoleamine 2,3-dioxygenase 1 (IDO1) DMIJGT9 MT DTT DMIJGT9 MA Inhibitor DMIJGT9 RN Incyte. Product Development Pipeline. DMIJGT9 RU http://www.incyte.com/drugs_product_pipeline.html DMZA2K0 DI DMZA2K0 DMZA2K0 DN INCSHR1210 DMZA2K0 MI TTNBFWK DMZA2K0 MN Programmed cell death protein 1 (PD-1) DMZA2K0 MT DTT DMZA2K0 MA Inhibitor DMZA2K0 RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMZA2K0 RU http://phrma-docs.phrma.org/files/dmfile/MID_Immuno-Oncology-2017_Drug-List1.pdf DMLG96Z DI DMLG96Z DMLG96Z DN INM-176 DMLG96Z MI TT1RS9F DMLG96Z MN Acetylcholinesterase (AChE) DMLG96Z MT DTT DMLG96Z MA Inhibitor DMLG96Z RN The memory ameliorating effects of INM-176, an ethanolic extract of Angelica gigas, against scopolamine- or Abeta(1-42)-induced cognitive dysfunction in mice. J Ethnopharmacol. 2012 Sep 28;143(2):611-20. DMLG96Z RU https://pubmed.ncbi.nlm.nih.gov/22846435 DM5L8QT DI DM5L8QT DM5L8QT DN INO-1001 DM5L8QT MI TTEBCY8 DM5L8QT MN Poly [ADP-ribose] polymerase (PARP) DM5L8QT MT DTT DM5L8QT MA Modulator DM5L8QT RN Therapeutic injection of PARP inhibitor INO-1001 preserves cardiac function in porcine myocardial ischemia and reperfusion without reducing infarct size. Shock. 2010 May;33(5):507-12. DM5L8QT RU https://pubmed.ncbi.nlm.nih.gov/20395771 DMUS1F8 DI DMUS1F8 DMUS1F8 DN Inolimomab DMUS1F8 MI TT10Y9E DMUS1F8 MN Interleukin 2 receptor alpha (IL2RA) DMUS1F8 MT DTT DMUS1F8 MA Modulator DMUS1F8 RN Encouraging results with inolimomab (anti-IL-2 receptor) as treatment for refractory acute graft-versus-host disease.Biol Blood Marrow Transplant.2006 Nov;12(11):1135-41. DMUS1F8 RU https://www.ncbi.nlm.nih.gov/pubmed/17085306 DMOTH6V DI DMOTH6V DMOTH6V DN Interferon alpha 2a DMOTH6V MI TTSIUJ9 DMOTH6V MN Interferon-alpha 2 (IFNA2) DMOTH6V MT DTT DMOTH6V MA Modulator DMOTH6V RN Hairy cell leukemia associated with large granular lymphocyte leukemia: immunologic and genomic study, effect of interferon treatment. Blood. 1988 Aug;72(2):655-60. DMOTH6V RU https://pubmed.ncbi.nlm.nih.gov/2840988 DMZA47Y DI DMZA47Y DMZA47Y DN Iomab-B DMZA47Y MI TTUS45N DMZA47Y MN Leukocyte common antigen (PTPRC) DMZA47Y MT DTT DMZA47Y RN Clinical pipeline report, company report or official report of Actinium Pharmaceuticals. DMZA47Y RU http://www.actiniumpharma.com/products/pipeline/iomab-b/ DMSV12M DI DMSV12M DMSV12M DN Isavuconazole DMSV12M MI DE4LYSA DMSV12M MN Cytochrome P450 3A4 (CYP3A4) DMSV12M MT DME DMSV12M MA Metabolism DMSV12M RN Pharmacokinetic evaluation of CYP3A4-mediated drug-drug interactions of isavuconazole with rifampin, ketoconazole, midazolam, and ethinyl estradiol/norethindrone in healthy adults. Clin Pharmacol Drug Dev. 2017 Jan;6(1):44-53. DMSV12M RU https://www.ncbi.nlm.nih.gov/pubmed/?term=27273461 DMQZI7K DI DMQZI7K DMQZI7K DN ISIS 23722 DMQZI7K MI TTTPU1G DMQZI7K MN Apoptosis inhibitor survivin (BIRC5) DMQZI7K MT DTT DMQZI7K MA Modulator DMQZI7K RN Targeted BIRC5 silencing using YM155 causes cell death in neuroblastoma cells with low ABCB1 expression.Eur J Cancer.2012 Mar;48(5):763-71. DMQZI7K RU https://www.ncbi.nlm.nih.gov/pubmed/22088485 DMKWBJR DI DMKWBJR DMKWBJR DN ISIS-PKK DMKWBJR MI TTN0PCX DMKWBJR MN Plasma kallikrein messenger RNA (KLKB1 mRNA) DMKWBJR MT DTT DMKWBJR RN Clinical pipeline report, company report or official report of ISIS Pharmaceuticals. DMKWBJR RU https://www.isispharm.com/pipeline/isis-pkkrx/ DM4U5NF DI DM4U5NF DM4U5NF DN ISIS-TTR DM4U5NF MI TTPOYU7 DM4U5NF MN Transthyretin messenger RNA (TTR mRNA) DM4U5NF MT DTT DM4U5NF RN Clinical pipeline report, company report or official report of ISIS Pharmaceuticals (2011). DM4U5NF RU http://www.isispharm.com/index.htm DMBJTVL DI DMBJTVL DMBJTVL DN Isotretinoin DMBJTVL MI TTNHMO8 DMBJTVL MN COVID-19 papain-like proteinase (PL-PRO) DMBJTVL MT DTT DMBJTVL MA Inhibitor DMBJTVL RN ClinicalTrials.gov (NCT04361422) Isotretinoin in Treatment of COVID-19. U.S. National Institutes of Health. DMBJTVL RU https://clinicaltrials.gov/ct2/show/NCT04361422 DMP61YB DI DMP61YB DMP61YB DN ISRAPAFANT DMP61YB MI TTQL5VC DMP61YB MN Platelet-activating factor receptor (PTAFR) DMP61YB MT DTT DMP61YB MA Antagonist DMP61YB RN Amino acid residues critical for endoplasmic reticulum export and trafficking of platelet-activating factor receptor. J Biol Chem. 2010 Feb 19;285(8):5931-40. DMP61YB RU https://pubmed.ncbi.nlm.nih.gov/20007715 DMNDGWE DI DMNDGWE DMNDGWE DN IT-101 DMNDGWE MI TTQHWNA DMNDGWE MN Hypoxia-inducible factor 1 alpha (HIF-1A) DMNDGWE MT DTT DMNDGWE MA Inhibitor DMNDGWE RN CRLX101, an investigational camptothecin-containing nanoparticle-drug conjugate, targets cancer stem cells and impedes resistance to antiangiogenic therapy in mouse models of breast cancer. Breast Cancer Res Treat. 2015 Apr;150(3):559-67. DMNDGWE RU https://pubmed.ncbi.nlm.nih.gov/25833208 DMFZBNE DI DMFZBNE DMFZBNE DN ITF2357 DMFZBNE MI TTBH0VX DMFZBNE MN Histone deacetylase (HDAC) DMFZBNE MT DTT DMFZBNE MA Inhibitor DMFZBNE RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMFZBNE RU http://phrma-docs.phrma.org/files/dmfile/MID_Neurological-Disorders-Drug-List_2018.pdf DMFZBNE DI DMFZBNE DMFZBNE DN ITF2357 DMFZBNE MI TT6R7JZ DMFZBNE MN Histone deacetylase 1 (HDAC1) DMFZBNE MT DTT DMFZBNE MA Inhibitor DMFZBNE RN Emerging drugs for the therapy of primary and post essential thrombocythemia, post polycythemia vera myelofibrosis. Expert Opin Emerg Drugs. 2009 Sep;14(3):471-9. DMFZBNE RU https://pubmed.ncbi.nlm.nih.gov/19552608 DMFZBNE DI DMFZBNE DMFZBNE DN ITF2357 DMFZBNE MI TTRMX3V DMFZBNE MN Janus kinase 2 (JAK-2) DMFZBNE MT DTT DMFZBNE MA Inhibitor DMFZBNE RN Emerging drugs for the therapy of primary and post essential thrombocythemia, post polycythemia vera myelofibrosis. Expert Opin Emerg Drugs. 2009 Sep;14(3):471-9. DMFZBNE RU https://pubmed.ncbi.nlm.nih.gov/19552608 DMUQ1DO DI DMUQ1DO DMUQ1DO DN ITI-007 DMUQ1DO MI TTJQOD7 DMUQ1DO MN 5-HT 2A receptor (HTR2A) DMUQ1DO MT DTT DMUQ1DO MA Antagonist DMUQ1DO RN Clinical pipeline report, company report or official report of Intra-Cellular Therapies, Inc. DMUQ1DO RU http://www.intracellulartherapies.com/products-technology/iti-007.html DMUQ1DO DI DMUQ1DO DMUQ1DO DN ITI-007 DMUQ1DO MI TT85JO3 DMUQ1DO MN 5-HT receptor (5HTR) DMUQ1DO MT DTT DMUQ1DO MA Antagonist DMUQ1DO RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMUQ1DO RU http://phrma-docs.phrma.org/files/dmfile/MID_Mental-Illness-2017-Drug-List_Final.pdf DMUQ1DO DI DMUQ1DO DMUQ1DO DN ITI-007 DMUQ1DO MI TT3ROYC DMUQ1DO MN Serotonin transporter (SERT) DMUQ1DO MT DTT DMUQ1DO MA Antagonist DMUQ1DO RN Clinical pipeline report, company report or official report of Intra-Cellular Therapies, Inc. DMUQ1DO RU http://www.intracellulartherapies.com/products-technology/iti-007.html DMGWVLX DI DMGWVLX DMGWVLX DN Itolizumab DMGWVLX MI TTMF6KC DMGWVLX MN T-cell differentiation antigen CD6 (TP120) DMGWVLX MT DTT DMGWVLX RN Efficacy and safety of itolizumab, a novel anti-CD6 monoclonal antibody, in patients with moderate to severe chronic plaque psoriasis: results of a double-blind, randomized, placebo-controlled, phase-III study. J Am Acad Dermatol. 2014 Sep;71(3):484-92. DMGWVLX RU https://pubmed.ncbi.nlm.nih.gov/24703722 DM7MLTR DI DM7MLTR DM7MLTR DN Itopride DM7MLTR MI DEP76YL DM7MLTR MN Dimethylaniline oxidase 3 (FMO3) DM7MLTR MT DME DM7MLTR MA Metabolism DM7MLTR RN Development of a physiologically based pharmacokinetic model to predict the effects of flavin-containing monooxygenase 3 (FMO3) polymorphisms on itopride exposure. Biopharm Drug Dispos. 2017 Sep;38(6):389-393. DM7MLTR RU https://www.ncbi.nlm.nih.gov/pubmed/?term=28255999 DMNORK8 DI DMNORK8 DMNORK8 DN Jakafi DMNORK8 MI DE4LYSA DMNORK8 MN Cytochrome P450 3A4 (CYP3A4) DMNORK8 MT DME DMNORK8 MA Metabolism DMNORK8 RN Ruxolitinib: in the treatment of myelofibrosis. Drugs. 2012 Nov 12;72(16):2117-27. DMNORK8 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=23061804 DM8FSPV DI DM8FSPV DM8FSPV DN JTZ-951 DM8FSPV MI TTJQFBG DM8FSPV MN HIF-prolyl hydroxylase (HPH) DM8FSPV MT DTT DM8FSPV MA Modulator DM8FSPV RN DOI: 10.1038/nrneph.2015.82 DM8FSPV RU http://www.nature.com/nrneph/journal/v11/n7/fig_tab/nrneph.2015.82_T1.html DM5WCV4 DI DM5WCV4 DM5WCV4 DN JX-594 DM5WCV4 MI TTNYZG2 DM5WCV4 MN Granulocyte-macrophage colony-stimulating factor (CSF2) DM5WCV4 MT DTT DM5WCV4 MA Modulator DM5WCV4 RN Systemic armed oncolytic and immunologic therapy for cancer with JX-594, a targeted poxvirus expressing GM-CSF. Mol Ther. 2006 Sep;14(3):361-70. DM5WCV4 RU https://pubmed.ncbi.nlm.nih.gov/16905462 DM9J0KD DI DM9J0KD DM9J0KD DN K-103-IP DM9J0KD MI TTK0943 DM9J0KD MN Prostaglandin G/H synthase (COX) DM9J0KD MT DTT DM9J0KD MA Modulator DM9J0KD RN ClinicalTrials.gov (NCT02089425) An Efficacy and Safety Study for the Treatment of Mild to Moderate Acute Pain Associated With Ankle Strain or Sprain.. U.S. National Institutes of Health. DM9J0KD RU https://clinicaltrials.gov/ct2/show/NCT02089425 DMCRGY4 DI DMCRGY4 DMCRGY4 DN Karenitecin DMCRGY4 MI DTI7UX6 DMCRGY4 MN Breast cancer resistance protein (ABCG2) DMCRGY4 MT DTP DMCRGY4 MA Substrate DMCRGY4 RN Pharmacogenomic importance of ABCG2. Pharmacogenomics. 2008 Aug;9(8):1005-9. DMCRGY4 RU https://doi.org/10.2217/14622416.9.8.1005 DMCRGY4 DI DMCRGY4 DMCRGY4 DN Karenitecin DMCRGY4 MI DES5XRU DMCRGY4 MN Cytochrome P450 2C8 (CYP2C8) DMCRGY4 MT DME DMCRGY4 MA Metabolism DMCRGY4 RN Evaluation of in vitro drug interactions with karenitecin, a novel, highly lipophilic camptothecin derivative in phase II clinical development. J Clin Pharmacol. 2003 Sep;43(9):1008-14. DMCRGY4 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=12971034 DMCRGY4 DI DMCRGY4 DMCRGY4 DN Karenitecin DMCRGY4 MI DECB0K3 DMCRGY4 MN Cytochrome P450 2D6 (CYP2D6) DMCRGY4 MT DME DMCRGY4 MA Metabolism DMCRGY4 RN Evaluation of in vitro drug interactions with karenitecin, a novel, highly lipophilic camptothecin derivative in phase II clinical development. J Clin Pharmacol. 2003 Sep;43(9):1008-14. DMCRGY4 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=12971034 DMCRGY4 DI DMCRGY4 DMCRGY4 DN Karenitecin DMCRGY4 MI DE4LYSA DMCRGY4 MN Cytochrome P450 3A4 (CYP3A4) DMCRGY4 MT DME DMCRGY4 MA Metabolism DMCRGY4 RN Evaluation of in vitro drug interactions with karenitecin, a novel, highly lipophilic camptothecin derivative in phase II clinical development. J Clin Pharmacol. 2003 Sep;43(9):1008-14. DMCRGY4 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=12971034 DMCRGY4 DI DMCRGY4 DMCRGY4 DN Karenitecin DMCRGY4 MI TT2GPK3 DMCRGY4 MN DNA topoisomerase (TOP) DMCRGY4 MT DTT DMCRGY4 MA Inhibitor DMCRGY4 RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMCRGY4 RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DMCRGY4 DI DMCRGY4 DMCRGY4 DN Karenitecin DMCRGY4 MI TTGTQHC DMCRGY4 MN DNA topoisomerase I (TOP1) DMCRGY4 MT DTT DMCRGY4 MA Inhibitor DMCRGY4 RN Characterization of protein kinase chk1 essential for the cell cycle checkpoint after exposure of human head and neck carcinoma A253 cells to a novel topoisomerase I inhibitor BNP1350. Mol Pharmacol.2000 Mar;57(3):453-9. DMCRGY4 RU https://pubmed.ncbi.nlm.nih.gov/10692484 DMCRGY4 DI DMCRGY4 DMCRGY4 DN Karenitecin DMCRGY4 MI DT3D8F0 DMCRGY4 MN Organic anion transporting polypeptide 1B1 (SLCO1B1) DMCRGY4 MT DTP DMCRGY4 MA Substrate DMCRGY4 RN Organic anion transporting polypeptide 1B1: a genetically polymorphic transporter of major importance for hepatic drug uptake. Pharmacol Rev. 2011 Mar;63(1):157-81. DMCRGY4 RU http://www.ncbi.nlm.nih.gov/pubmed/21245207 DM8VO16 DI DM8VO16 DM8VO16 DN KH-902 DM8VO16 MI TTVJ1D8 DM8VO16 MN Vascular endothelial growth factor receptor (VEGFR) DM8VO16 MT DTT DM8VO16 MA Modulator DM8VO16 RN Effects of intravitreal injection of KH902, a vascular endothelial growth factor receptor decoy, on the retinas of streptozotocin-induced diabetic rats. Diabetes Obes Metab. 2012 Jul;14(7):644-53. DM8VO16 RU https://pubmed.ncbi.nlm.nih.gov/22340191 DMSDBPG DI DMSDBPG DMSDBPG DN KN046 DMSDBPG MI TTI2S1D DMSDBPG MN Cytotoxic T-lymphocyte protein 4 (CTLA-4) DMSDBPG MT DTT DMSDBPG MA Inhibitor DMSDBPG RN Clinical pipeline report, company report or official report of Alphamab Oncology. DMSDBPG RU http://www.alphamabonc.com/pipeline/kn046.html DMSDBPG DI DMSDBPG DMSDBPG DN KN046 DMSDBPG MI TT8ZLTI DMSDBPG MN Programmed cell death 1 ligand 1 (PD-L1) DMSDBPG MT DTT DMSDBPG MA Inhibitor DMSDBPG RN Clinical pipeline report, company report or official report of Alphamab Oncology. DMSDBPG RU http://www.alphamabonc.com/pipeline/kn046.html DMP5G1K DI DMP5G1K DMP5G1K DN KPS-0373 DMP5G1K MI TT2Z39D DMP5G1K MN Thyrotropin-releasing hormone (TRH) DMP5G1K MT DTT DMP5G1K MA Modulator DMP5G1K RN DOI: 10.1002/mdc3.12057 DMP5G1K RU http://www.movementdisorders.org/MDS/Journals/Clinical-Practice-E-Journal-Overview/Movement-Disorders-Clinical-Practice-E-Journal-Volume-1-Issue-4/Treatment-Options-in-Degenerative-Cerebellar-Ataxia-A-Systematic-Review.htm DMM2LTC DI DMM2LTC DMM2LTC DN KSI-301 DMM2LTC MI TT9HKJA DMM2LTC MN Vascular endothelial growth factor (VEGF) DMM2LTC MT DTT DMM2LTC MA Inhibitor DMM2LTC RN Clinical pipeline report, company report or official report of Kodiak Sciences. DMM2LTC RU https://kodiak.com/our-pipeline/ DMP3GI2 DI DMP3GI2 DMP3GI2 DN KW-3357 DMP3GI2 MI TT4QPUL DMP3GI2 MN Antithrombin-III (ATIII) DMP3GI2 MT DTT DMP3GI2 MA Modulator DMP3GI2 RN Company report (kyowa-kirin) DMP3GI2 RU http://www.kyowa-kirin.com/news_releases/2014/e20140801_01.html DMF0NA9 DI DMF0NA9 DMF0NA9 DN KX-01 DMF0NA9 MI TT6PKBN DMF0NA9 MN Proto-oncogene c-Src (SRC) DMF0NA9 MT DTT DMF0NA9 MA Inhibitor DMF0NA9 RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMF0NA9 RU http://phrma-docs.phrma.org/files/dmfile/MID_Skin_Diseases_2018_9_FINAL.pdf DMWTPCA DI DMWTPCA DMWTPCA DN L-651582 DMWTPCA MI DE4LYSA DMWTPCA MN Cytochrome P450 3A4 (CYP3A4) DMWTPCA MT DME DMWTPCA MA Metabolism DMWTPCA RN Integrated analysis on the physicochemical properties of dihydropyridine calcium channel blockers in grapefruit juice interactions. Curr Pharm Biotechnol. 2012 Jul;13(9):1705-17. DMWTPCA RU https://www.ncbi.nlm.nih.gov/pubmed/?term=22039822 DMWTPCA DI DMWTPCA DMWTPCA DN L-651582 DMWTPCA MI TTH18TF DMWTPCA MN Muscarinic acetylcholine receptor M5 (CHRM5) DMWTPCA MT DTT DMWTPCA MA Modulator DMWTPCA RN The antiproliferative and antimetastatic compound L651582 inhibits muscarinic acetylcholine receptor-stimulated calcium influx and arachidonic acid release. J Pharmacol Exp Ther. 1991 Jun;257(3):967-71. DMWTPCA RU https://pubmed.ncbi.nlm.nih.gov/1646332 DMI3YLK DI DMI3YLK DMI3YLK DN LA-EP2006 DMI3YLK MI TT5TQ2W DMI3YLK MN Granulocyte colony-stimulating factor (CSF3) DMI3YLK MT DTT DMI3YLK MA Modulator DMI3YLK RN National Cancer Institute Drug Dictionary (drug id 724518). DMI3YLK RU http://www.cancer.gov/publications/dictionaries/cancer-drug?cdrid=724518 DMA2NYS DI DMA2NYS DMA2NYS DN Lampalizumab DMA2NYS MI TT8D13I DMA2NYS MN Complement factor D (CFD) DMA2NYS MT DTT DMA2NYS MA Inhibitor DMA2NYS RN In Vivo Stability Profiles of Anti-factor D Molecules Support Long-Acting Delivery Approaches. Mol Pharm. 2019 Jan 7;16(1):86-95. DMA2NYS RU https://pubmed.ncbi.nlm.nih.gov/30444371 DMFJLB6 DI DMFJLB6 DMFJLB6 DN Lanabecestat DMFJLB6 MI TT8JRS7 DMFJLB6 MN Beta-secretase (BACE) DMFJLB6 MT DTT DMFJLB6 MA Inhibitor DMFJLB6 RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMFJLB6 RU http://phrma-docs.phrma.org/files/dmfile/MID_Neurological-Disorders-Drug-List_2018.pdf DM4EGPN DI DM4EGPN DM4EGPN DN Lanperisone DM4EGPN MI TT84DRB DM4EGPN MN Voltage-gated sodium channel alpha Nav1.4 (SCN4A) DM4EGPN MT DTT DM4EGPN MA Modulator DM4EGPN RN Tolperisone-type drugs inhibit spinal reflexes via blockade of voltage-gated sodium and calcium channels. J Pharmacol Exp Ther. 2005 Dec;315(3):1237-46. DM4EGPN RU https://pubmed.ncbi.nlm.nih.gov/16126840 DMMA0C7 DI DMMA0C7 DMMA0C7 DN Laquinamod DMMA0C7 MI TTZF0K2 DMMA0C7 MN C-X-C motif chemokine 2 (CXCL2) DMMA0C7 MT DTT DMMA0C7 MA Modulator DMMA0C7 RN Multiple sclerosis: current and future treatment options. Endocr Metab Immune Disord Drug Targets. 2007 Dec;7(4):292-9. DMMA0C7 RU https://pubmed.ncbi.nlm.nih.gov/18220950 DM3IWS8 DI DM3IWS8 DM3IWS8 DN Laquinimod DM3IWS8 MI DE4LYSA DM3IWS8 MN Cytochrome P450 3A4 (CYP3A4) DM3IWS8 MT DME DM3IWS8 MA Metabolism DM3IWS8 RN Oral laquinimod treatment in multiple sclerosis. Neurologia. 2011 Mar;26(2):111-7. DM3IWS8 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=21163185 DM3IWS8 DI DM3IWS8 DM3IWS8 DN Laquinimod DM3IWS8 MI TTSXVID DM3IWS8 MN Nuclear factor NF-kappa-B (NFKB) DM3IWS8 MT DTT DM3IWS8 MA Modulator DM3IWS8 RN Reduced astrocytic NF- B activation by laquinimod protects from cuprizone-induced demyelination. Acta Neuropathol. 2012 Sep;124(3):411-24. DM3IWS8 RU https://pubmed.ncbi.nlm.nih.gov/22766690 DMH2EA1 DI DMH2EA1 DMH2EA1 DN Laromustine DMH2EA1 MI TTUTN1I DMH2EA1 MN Human Deoxyribonucleic acid (hDNA) DMH2EA1 MT DTT DMH2EA1 MA Binder DMH2EA1 RN Phase I study of temozolomide and laromustine (VNP40101M) in patients with relapsed or refractory leukemia. Clin Lymphoma Myeloma Leuk. 2010 Jun;10(3):211-6. DMH2EA1 RU https://pubmed.ncbi.nlm.nih.gov/20511167 DMAJM12 DI DMAJM12 DMAJM12 DN LATIN T1D DMAJM12 MI TTVIMDE DMAJM12 MN Glucagon-like peptide 1 receptor (GLP1R) DMAJM12 MT DTT DMAJM12 MA Agonist DMAJM12 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 249). DMAJM12 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=249 DM09RKB DI DM09RKB DM09RKB DN LC-150444 DM09RKB MI TTDIGC1 DM09RKB MN Dipeptidyl peptidase 4 (DPP-4) DM09RKB MT DTT DM09RKB MA Inhibitor DM09RKB RN Clinical pipeline report, company report or official report of ShangHai APIs Chemical. DM09RKB RU http://www.apischemical.com/APIsproducts4/850649-62-6,Alogliptin(SYR-322).htm DMT4K0Z DI DMT4K0Z DMT4K0Z DN L-citrulline DMT4K0Z MI DTP7AEQ DMT4K0Z MN Glycoprotein-associated amino acid transporter b0, +AT1 (SLC7A9) DMT4K0Z MT DTP DMT4K0Z MA Substrate DMT4K0Z RN Transport characteristics of L-citrulline in renal apical membrane of proximal tubular cells. Biopharm Drug Dispos. 2009 Apr;30(3):126-37. DMT4K0Z RU http://www.ncbi.nlm.nih.gov/pubmed/19322909 DMT4K0Z DI DMT4K0Z DMT4K0Z DN L-citrulline DMT4K0Z MI TTI1PRE DMT4K0Z MN G-protein coupled receptor GPCR33 (GPRC6A) DMT4K0Z MT DTT DMT4K0Z MA Agonist DMT4K0Z RN Deorphanization of GPRC6A: a promiscuous L-alpha-amino acid receptor with preference for basic amino acids. Mol Pharmacol. 2005 Mar;67(3):589-97. DMT4K0Z RU https://pubmed.ncbi.nlm.nih.gov/15576628 DMFLJHQ DI DMFLJHQ DMFLJHQ DN LCQ908 DMFLJHQ MI TTF8P9I DMFLJHQ MN Diacylglycerol acyltransferase 1 (DGAT1) DMFLJHQ MT DTT DMFLJHQ MA Modulator DMFLJHQ RN DGAT1 inhibitors as anti-obesity and anti-diabetic agents. Curr Opin Drug Discov Devel. 2010 Jul;13(4):489-96. DMFLJHQ RU https://pubmed.ncbi.nlm.nih.gov/20597032 DMFLJHQ DI DMFLJHQ DMFLJHQ DN LCQ908 DMFLJHQ MI DEYGVN4 DMFLJHQ MN UDP-glucuronosyltransferase 1A1 (UGT1A1) DMFLJHQ MT DME DMFLJHQ MA Metabolism DMFLJHQ RN Pradigastat disposition in humans: in vivo and in vitro investigations. Xenobiotica. 2017 Dec;47(12):1077-1089. DMFLJHQ RU https://www.ncbi.nlm.nih.gov/pubmed/?term=27855567 DMFLJHQ DI DMFLJHQ DMFLJHQ DN LCQ908 DMFLJHQ MI DEF2WXN DMFLJHQ MN UDP-glucuronosyltransferase 1A3 (UGT1A3) DMFLJHQ MT DME DMFLJHQ MA Metabolism DMFLJHQ RN Pradigastat disposition in humans: in vivo and in vitro investigations. Xenobiotica. 2017 Dec;47(12):1077-1089. DMFLJHQ RU https://www.ncbi.nlm.nih.gov/pubmed/?term=27855567 DMFLJHQ DI DMFLJHQ DMFLJHQ DN LCQ908 DMFLJHQ MI DEB3CV1 DMFLJHQ MN UDP-glucuronosyltransferase 2B7 (UGT2B7) DMFLJHQ MT DME DMFLJHQ MA Metabolism DMFLJHQ RN Pradigastat disposition in humans: in vivo and in vitro investigations. Xenobiotica. 2017 Dec;47(12):1077-1089. DMFLJHQ RU https://www.ncbi.nlm.nih.gov/pubmed/?term=27855567 DMQP0X5 DI DMQP0X5 DMQP0X5 DN Lebrikizumab DMQP0X5 MI TT0GVCH DMQP0X5 MN Interleukin-13 (IL13) DMQP0X5 MT DTT DMQP0X5 MA Modulator DMQP0X5 RN The potential of biologics for the treatment of asthma. Nat Rev Drug Discov. 2012 Dec;11(12):958-72. DMQP0X5 RU https://www.ncbi.nlm.nih.gov/pubmed/23197041 DMMX75K DI DMMX75K DMMX75K DN LEE011 DMMX75K MI TT0PG8F DMMX75K MN Cyclin-dependent kinase 4 (CDK4) DMMX75K MT DTT DMMX75K MA Modulator DMMX75K RN Dual CDK4/CDK6 inhibition induces cell-cycle arrest and senescence in neuroblastoma. Clin Cancer Res. 2013 Nov 15;19(22):6173-82. DMMX75K RU https://pubmed.ncbi.nlm.nih.gov/24045179 DMMX75K DI DMMX75K DMMX75K DN LEE011 DMMX75K MI TTO0FDJ DMMX75K MN Cyclin-dependent kinase 6 (CDK6) DMMX75K MT DTT DMMX75K MA Modulator DMMX75K RN Dual CDK4/CDK6 inhibition induces cell-cycle arrest and senescence in neuroblastoma. Clin Cancer Res. 2013 Nov 15;19(22):6173-82. DMMX75K RU https://pubmed.ncbi.nlm.nih.gov/24045179 DMSCGM8 DI DMSCGM8 DMSCGM8 DN LentiGlobin DMSCGM8 MI TTM6HK1 DMSCGM8 MN Hemoglobin subunit beta (HBB) DMSCGM8 MT DTT DMSCGM8 MA Modulator DMSCGM8 RN Preclinical evaluation of efficacy and safety of an improved lentiviral vector for the treatment of beta-thalassemia and sickle cell disease. Curr Gene Ther. 2015;15(1):64-81. DMSCGM8 RU https://pubmed.ncbi.nlm.nih.gov/25429463 DMSRIT4 DI DMSRIT4 DMSRIT4 DN Lenzilumab DMSRIT4 MI TTPZGYX DMSRIT4 MN HUMAN colony-stimulating factor (GM-CSF) DMSRIT4 MT DTT DMSRIT4 MA Inhibitor DMSRIT4 RN The anti-viral facet of anti-rheumatic drugs: Lessons from COVID-19. J Autoimmun. 2020 Apr 17:102468. DMSRIT4 RU https://pubmed.ncbi.nlm.nih.gov/32317220 DMOTCIU DI DMOTCIU DMOTCIU DN Lerisetron DMOTCIU MI TTNXLKE DMOTCIU MN 5-HT 3 receptor (5HT3R) DMOTCIU MT DTT DMOTCIU MA Antagonist DMOTCIU RN Emerging drugs for chemotherapy-induced emesis. Expert Opin Emerg Drugs. 2006 Mar;11(1):137-51. DMOTCIU RU https://pubmed.ncbi.nlm.nih.gov/16503832 DMAYC76 DI DMAYC76 DMAYC76 DN Levomequitazine DMAYC76 MI TT7CXIM DMAYC76 MN Histamine receptor (HR) DMAYC76 MT DTT DMAYC76 MA Antagonist DMAYC76 RN Oxidation of histamine H1 antagonist mequitazine is catalyzed by cytochrome P450 2D6 in human liver microsomes. J Pharmacol Exp Ther. 1998 Feb;284(2):437-42. DMAYC76 RU https://pubmed.ncbi.nlm.nih.gov/9454781 DM103O8 DI DM103O8 DM103O8 DN Ligelizumab DM103O8 MI TTYJQTF DM103O8 MN Immunoglobulin E (IgE) DM103O8 MT DTT DM103O8 MA Inhibitor DM103O8 RN Clinical pipeline report, company report or official report of Novartis. DM103O8 RU https://www.novartis.com/our-science/novartis-global-pipeline?search_api_views_fulltext=Ligelizumab&field_pipeline_filing_date=All DMNM93X DI DMNM93X DMNM93X DN Linagliptin DMNM93X MI TTF928K DMNM93X MN HUMAN dipeptidyl peptidase 4 (DPP-4) DMNM93X MT DTT DMNM93X MA Inhibitor DMNM93X RN DPP4 inhibition: preventing SARS-CoV-2 infection and/or progression of COVID-19 Diabetes Metab Res Rev. 2020 Apr 26. DMNM93X RU https://pubmed.ncbi.nlm.nih.gov/32336007 DM0ZOGX DI DM0ZOGX DM0ZOGX DN Linopirdine DM0ZOGX MI DE4LYSA DM0ZOGX MN Cytochrome P450 3A4 (CYP3A4) DM0ZOGX MT DME DM0ZOGX MA Metabolism DM0ZOGX RN Induction of cytochromes P-450 2B and 3A in mice following the dietary administration of the novel cognitive enhancer linopirdine. Drug Metab Dispos. 1994 Jan-Feb;22(1):65-73. DM0ZOGX RU https://www.ncbi.nlm.nih.gov/pubmed/?term=8149892 DM0ZOGX DI DM0ZOGX DM0ZOGX DN Linopirdine DM0ZOGX MI DEIBDNY DM0ZOGX MN Cytochrome P450 3A5 (CYP3A5) DM0ZOGX MT DME DM0ZOGX MA Metabolism DM0ZOGX RN Induction of cytochromes P-450 2B and 3A in mice following the dietary administration of the novel cognitive enhancer linopirdine. Drug Metab Dispos. 1994 Jan-Feb;22(1):65-73. DM0ZOGX RU https://www.ncbi.nlm.nih.gov/pubmed/?term=8149892 DM0ZOGX DI DM0ZOGX DM0ZOGX DN Linopirdine DM0ZOGX MI DERD86B DM0ZOGX MN Cytochrome P450 3A7 (CYP3A7) DM0ZOGX MT DME DM0ZOGX MA Metabolism DM0ZOGX RN Induction of cytochromes P-450 2B and 3A in mice following the dietary administration of the novel cognitive enhancer linopirdine. Drug Metab Dispos. 1994 Jan-Feb;22(1):65-73. DM0ZOGX RU https://www.ncbi.nlm.nih.gov/pubmed/?term=8149892 DM0ZOGX DI DM0ZOGX DM0ZOGX DN Linopirdine DM0ZOGX MI TTIVDM3 DM0ZOGX MN Voltage-gated potassium channel Kv7.3 (KCNQ3) DM0ZOGX MT DTT DM0ZOGX MA Modulator DM0ZOGX RN The M-channel blocker linopirdine is an agonist of the capsaicin receptor TRPV1. J Pharmacol Sci. 2010;114(3):332-40. DM0ZOGX RU https://pubmed.ncbi.nlm.nih.gov/21099148 DMNF4UH DI DMNF4UH DMNF4UH DN Liprotamase DMNF4UH MI TT7MRGU DMNF4UH MN Chymotrypsin (CTR) DMNF4UH MT DTT DMNF4UH MA Modulator DMNF4UH RN Clinical pipeline report, company report or official report of Anthera Pharmaceuticals. DMNF4UH RU http://investor.anthera.com/releasedetail.cfm?releaseid=859598 DMNF4UH DI DMNF4UH DMNF4UH DN Liprotamase DMNF4UH MI TTCGSZ4 DMNF4UH MN Pancreatic alpha-amylase (AMY2A) DMNF4UH MT DTT DMNF4UH MA Modulator DMNF4UH RN Clinical pipeline report, company report or official report of Anthera Pharmaceuticals. DMNF4UH RU http://investor.anthera.com/releasedetail.cfm?releaseid=859598 DMNF4UH DI DMNF4UH DMNF4UH DN Liprotamase DMNF4UH MI TTXMY0J DMNF4UH MN Pancreatic triacylglycerol lipase (PNLIP) DMNF4UH MT DTT DMNF4UH MA Modulator DMNF4UH RN Clinical pipeline report, company report or official report of Anthera Pharmaceuticals. DMNF4UH RU http://investor.anthera.com/releasedetail.cfm?releaseid=859598 DMKZRBP DI DMKZRBP DMKZRBP DN Litoxetine DMKZRBP MI TTNXLKE DMKZRBP MN 5-HT 3 receptor (5HT3R) DMKZRBP MT DTT DMKZRBP MA Modulator DMKZRBP RN Litoxetine: a selective 5-HT uptake inhibitor with concomitant 5-HT3 receptor antagonist and antiemetic properties. Eur J Pharmacol. 1993 Mar 2;232(2-3):139-45. DMKZRBP RU https://www.ncbi.nlm.nih.gov/pubmed/8385615 DMKZRBP DI DMKZRBP DMKZRBP DN Litoxetine DMKZRBP MI TT3ROYC DMKZRBP MN Serotonin transporter (SERT) DMKZRBP MT DTT DMKZRBP MA Modulator DMKZRBP RN Litoxetine: a selective 5-HT uptake inhibitor with concomitant 5-HT3 receptor antagonist and antiemetic properties. Eur J Pharmacol. 1993 Mar 2;232(2-3):139-45. DMKZRBP RU https://www.ncbi.nlm.nih.gov/pubmed/8385615 DMDN4ZP DI DMDN4ZP DMDN4ZP DN Lixivaptan DMDN4ZP MI TTV9GOF DMDN4ZP MN Histidine decarboxylase (HDC) DMDN4ZP MT DTT DMDN4ZP MA Inhibitor DMDN4ZP RN Clinical pipeline report, company report or official report of Biofrontera (2009). DMDN4ZP RU http://www.biofrontera.com/index.php?id=5 DMDN4ZP DI DMDN4ZP DMDN4ZP DN Lixivaptan DMDN4ZP MI TTK8R02 DMDN4ZP MN Vasopressin V2 receptor (V2R) DMDN4ZP MT DTT DMDN4ZP MA Antagonist DMDN4ZP RN Emerging drugs for acute and chronic heart failure: current and future developments. Expert Opin Emerg Drugs. 2007 Mar;12(1):75-95. DMDN4ZP RU https://pubmed.ncbi.nlm.nih.gov/17355215 DM4OAIU DI DM4OAIU DM4OAIU DN LMI070 DM4OAIU MI TT8QL6X DM4OAIU MN Survival motor neuron protein (SMN1) DM4OAIU MT DTT DM4OAIU MA Modulator DM4OAIU RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DM4OAIU RU http://phrma-docs.phrma.org/files/dmfile/MID_Neurological-Disorders-Drug-List_2018.pdf DMOFIBM DI DMOFIBM DMOFIBM DN LMT-X DMOFIBM MI TTS87KH DMOFIBM MN Microtubule-associated protein tau (MAPT) DMOFIBM MT DTT DMOFIBM MA Inhibitor DMOFIBM RN Clinical pipeline report, company report or official report of TauRx. DMOFIBM RU http://taurx.com/press-releases-announcements.html DMOFIBM DI DMOFIBM DMOFIBM DN LMT-X DMOFIBM MI TT9RZ03 DMOFIBM MN TAR DNA binding protein 43 (TARDBP) DMOFIBM MT DTT DMOFIBM MA Inhibitor DMOFIBM RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMOFIBM RU http://phrma-docs.phrma.org/files/dmfile/MID_Neurological-Disorders-Drug-List_2018.pdf DMOFIBM DI DMOFIBM DMOFIBM DN LMT-X DMOFIBM MI TTZGF8B DMOFIBM MN Tau protein aggregation (TauA) DMOFIBM MT DTT DMOFIBM MA Modulator DMOFIBM RN Successes and Failures for Drugs in Late-Stage Development for Alzheimer's Disease. Correction in: volume 31 on page 81. DMOFIBM RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4000701/ DM9EZM0 DI DM9EZM0 DM9EZM0 DN LNP023 DM9EZM0 MI TTA0P7K DM9EZM0 MN Complement factor B (CFB) DM9EZM0 MT DTT DM9EZM0 MA Inhibitor DM9EZM0 RN Discovery of 4-((2 S,4 S)-4-Ethoxy-1-((5-methoxy-7-methyl-1 H-indol-4-yl)methyl)piperidin-2-yl)benzoic Acid (LNP023), a Factor B Inhibitor Specifically Designed To Be Applicable to Treating a Diverse Array of Complement Mediated Diseases. J Med Chem. 2020 Jun 11;63(11):5697-5722. DM9EZM0 RU https://pubmed.ncbi.nlm.nih.gov/32073845 DMQNVR8 DI DMQNVR8 DMQNVR8 DN Lopinavir + ritonavir DMQNVR8 MI TT1D53B DMQNVR8 MN COVID-19 3C-like protease (3CLpro) DMQNVR8 MT DTT DMQNVR8 MA Inhibitor DMQNVR8 RN Coronavirus puts drug repurposing on the fast track. Nat Biotechnol. 2020 Apr;38(4):379-381. DMQNVR8 RU https://pubmed.ncbi.nlm.nih.gov/32205870 DMX0O9U DI DMX0O9U DMX0O9U DN Lopinavir + ritonavir + favipiravir DMX0O9U MI TT1D53B DMX0O9U MN COVID-19 3C-like protease (3CLpro) DMX0O9U MT DTT DMX0O9U MA Inhibitor DMX0O9U RN Coronavirus puts drug repurposing on the fast track. Nat Biotechnol. 2020 Apr;38(4):379-381. DMX0O9U RU https://pubmed.ncbi.nlm.nih.gov/32205870 DMNY05F DI DMNY05F DMNY05F DN Lopinavir + ritonavir + oseltamivir DMNY05F MI TT1D53B DMNY05F MN COVID-19 3C-like protease (3CLpro) DMNY05F MT DTT DMNY05F MA Inhibitor DMNY05F RN Coronavirus puts drug repurposing on the fast track. Nat Biotechnol. 2020 Apr;38(4):379-381. DMNY05F RU https://pubmed.ncbi.nlm.nih.gov/32205870 DMTL5Q0 DI DMTL5Q0 DMTL5Q0 DN Losartan DMTL5Q0 MI TTPKMXQ DMTL5Q0 MN HUMAN type-1 angiotensin II receptor (AGTR1) DMTL5Q0 MT DTT DMTL5Q0 MA Blocker DMTL5Q0 RN Controversies of renin-angiotensin system inhibition during the COVID-19 pandemic. Nat Rev Nephrol. 2020 Apr 3. DMTL5Q0 RU https://pubmed.ncbi.nlm.nih.gov/32246101 DMIL37Z DI DMIL37Z DMIL37Z DN Losmapimod DMIL37Z MI TTQBR95 DMIL37Z MN Stress-activated protein kinase 2a (p38 alpha) DMIL37Z MT DTT DMIL37Z MA Inhibitor DMIL37Z RN Clinical pipeline report, company report or official report of GlaxoSmithKline (2009). DMIL37Z RU http://www.gsk.com/investors/product_pipeline/docs/gsk-pipeline-feb09.pdf DMWGRQD DI DMWGRQD DMWGRQD DN LU AE58054 DMWGRQD MI TTJS8PY DMWGRQD MN 5-HT 6 receptor (HTR6) DMWGRQD MT DTT DMWGRQD MA Enhancer DMWGRQD RN Lu AE58054, a 5-HT6 antagonist, reverses cognitive impairment induced by subchronic phencyclidine in a novel object recognition test in rats. Int J Neuropsychopharmacol. 2010 Sep;13(8):1021-33. DMWGRQD RU https://pubmed.ncbi.nlm.nih.gov/20569520 DMWGRQD DI DMWGRQD DMWGRQD DN LU AE58054 DMWGRQD MI DECB0K3 DMWGRQD MN Cytochrome P450 2D6 (CYP2D6) DMWGRQD MT DME DMWGRQD MA Metabolism DMWGRQD RN Idalopirdine as a treatment for Alzheimer's disease. Expert Opin Investig Drugs. 2015;24(7):981-7. DMWGRQD RU https://www.ncbi.nlm.nih.gov/pubmed/?term=26022777 DMWGRQD DI DMWGRQD DMWGRQD DN LU AE58054 DMWGRQD MI DE4LYSA DMWGRQD MN Cytochrome P450 3A4 (CYP3A4) DMWGRQD MT DME DMWGRQD MA Metabolism DMWGRQD RN Idalopirdine as a treatment for Alzheimer's disease. Expert Opin Investig Drugs. 2015;24(7):981-7. DMWGRQD RU https://www.ncbi.nlm.nih.gov/pubmed/?term=26022777 DMNAYUJ DI DMNAYUJ DMNAYUJ DN Lu AF35700 DMNAYUJ MI TTEX248 DMNAYUJ MN Dopamine D2 receptor (D2R) DMNAYUJ MT DTT DMNAYUJ MA Modulator DMNAYUJ RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMNAYUJ RU http://phrma-docs.phrma.org/files/dmfile/MID_Mental-Illness-2017-Drug-List_Final.pdf DMMLXA9 DI DMMLXA9 DMMLXA9 DN LX-4211 DMMLXA9 MI TT2UE56 DMMLXA9 MN Sodium/glucose cotransporter 1 (SGLT1) DMMLXA9 MT DTT DMMLXA9 MA Modulator DMMLXA9 RN LX4211, a dual SGLT1/SGLT2 inhibitor, improved glycemic control in patients with type 2 diabetes in a randomized, placebo-controlled trial. Clin Pharmacol Ther. 2012 Aug;92(2):158-69. DMMLXA9 RU https://pubmed.ncbi.nlm.nih.gov/22739142 DMMLXA9 DI DMMLXA9 DMMLXA9 DN LX-4211 DMMLXA9 MI TTLWPVF DMMLXA9 MN Sodium/glucose cotransporter 2 (SGLT2) DMMLXA9 MT DTT DMMLXA9 MA Modulator DMMLXA9 RN LX4211, a dual SGLT1/SGLT2 inhibitor, improved glycemic control in patients with type 2 diabetes in a randomized, placebo-controlled trial. Clin Pharmacol Ther. 2012 Aug;92(2):158-69. DMMLXA9 RU https://pubmed.ncbi.nlm.nih.gov/22739142 DM1BXMY DI DM1BXMY DM1BXMY DN LY2605541 DM1BXMY MI TTZOPHG DM1BXMY MN Insulin (INS) DM1BXMY MT DTT DM1BXMY MA Modulator DM1BXMY RN LY2605541--a preferential hepato-specific insulin analogue. Diabetes. 2014 Feb;63(2):390-2. DM1BXMY RU https://pubmed.ncbi.nlm.nih.gov/24464715 DMEZ0H5 DI DMEZ0H5 DMEZ0H5 DN LY2963016 DMEZ0H5 MI TTZOPHG DMEZ0H5 MN Insulin (INS) DMEZ0H5 MT DTT DMEZ0H5 MA Agonist DMEZ0H5 RN Efficacy and safety of LY2963016 insulin glargine compared with insulin glargine (Lantus ) in patients with type 1 diabetes in a randomized controlled trial: the ELEMENT 1 study. Diabetes Obes Metab.2015 Aug;17(8):726-33. DMEZ0H5 RU https://pubmed.ncbi.nlm.nih.gov/25974640 DMWZIRJ DI DMWZIRJ DMWZIRJ DN LY404039 DMWZIRJ MI TT8A9EF DMWZIRJ MN Metabotropic glutamate receptor 3 (mGluR3) DMWZIRJ MT DTT DMWZIRJ MA Agonist DMWZIRJ RN Positive allosteric modulators of the metabotropic glutamate receptor 2 for the treatment of schizophrenia. Expert Opin Ther Pat. 2009 Sep;19(9):1259-75. DMWZIRJ RU https://pubmed.ncbi.nlm.nih.gov/19552508 DM7WORZ DI DM7WORZ DM7WORZ DN LY-686017 DM7WORZ MI TTZPO1L DM7WORZ MN Substance-P receptor (TACR1) DM7WORZ MT DTT DM7WORZ MA Antagonist DM7WORZ RN Stress-related neuropeptides and alcoholism: CRH, NPY and beyond. Alcohol. 2009 November; 43(7): 491-498. DM7WORZ RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2804869/ DM6LVCQ DI DM6LVCQ DM6LVCQ DN LY-CoV555 DM6LVCQ MI TTZ3COY DM6LVCQ MN COVID-19 spike glycoprotein (S) DM6LVCQ MT DTT DM6LVCQ MA Inhibitor DM6LVCQ RN Neutralizing Antibody LY-CoV555 for Outpatient Covid-19. Reply. N Engl J Med. 2021 Jan 14;384(2):189. DM6LVCQ RU https://pubmed.ncbi.nlm.nih.gov/33378611 DMGNC6T DI DMGNC6T DMGNC6T DN M-0011 DMGNC6T MI TTT2KE3 DMGNC6T MN Alpha-mannosidase (MANA) DMGNC6T MT DTT DMGNC6T MA Modulator DMGNC6T RN ClinicalTrials.gov (NCT01681953) A Placebo-Controlled Phase 3 Trial of Repeated Lamazym Treatment of Subjects With Alpha-Mannosidosis. U.S. National Institutes of Health. DMGNC6T RU https://clinicaltrials.gov/ct2/show/NCT01681953 DM7ZFBA DI DM7ZFBA DM7ZFBA DN M100907 DM7ZFBA MI TTJQOD7 DM7ZFBA MN 5-HT 2A receptor (HTR2A) DM7ZFBA MT DTT DM7ZFBA MA Antagonist DM7ZFBA RN Antagonism of 5-hydroxytryptamine(2a) receptors attenuates the behavioral effects of cocaine in rats. J Pharmacol Exp Ther. 2001 Apr;297(1):357-63. DM7ZFBA RU https://pubmed.ncbi.nlm.nih.gov/11259563 DM7ZFBA DI DM7ZFBA DM7ZFBA DN M100907 DM7ZFBA MI TTWJBZ5 DM7ZFBA MN 5-HT 2C receptor (HTR2C) DM7ZFBA MT DTT DM7ZFBA MA Inhibitor DM7ZFBA RN Non-basic ligands for aminergic GPCRs: the discovery and development diaryl sulfones as selective, orally bioavailable 5-HT2A receptor antagonists ... Bioorg Med Chem Lett. 2010 Jun 15;20(12):3708-12. DM7ZFBA RU https://pubmed.ncbi.nlm.nih.gov/20493697 DM7ZFBA DI DM7ZFBA DM7ZFBA DN M100907 DM7ZFBA MI TTQ6VDM DM7ZFBA MN Voltage-gated potassium channel Kv11.1 (KCNH2) DM7ZFBA MT DTT DM7ZFBA MA Inhibitor DM7ZFBA RN Non-basic ligands for aminergic GPCRs: the discovery and development diaryl sulfones as selective, orally bioavailable 5-HT2A receptor antagonists ... Bioorg Med Chem Lett. 2010 Jun 15;20(12):3708-12. DM7ZFBA RU https://pubmed.ncbi.nlm.nih.gov/20493697 DMZ6VD5 DI DMZ6VD5 DMZ6VD5 DN M-518101 DMZ6VD5 MI TTUST1O DMZ6VD5 MN Phosphodiesterase (PDE) DMZ6VD5 MT DTT DMZ6VD5 MA Inhibitor DMZ6VD5 RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMZ6VD5 RU http://phrma-docs.phrma.org/files/dmfile/medicines-in-development-drug-list-autoimmune-diseases.pdf DM1PRT6 DI DM1PRT6 DM1PRT6 DN M710 DM1PRT6 MI TT9HKJA DM1PRT6 MN Vascular endothelial growth factor (VEGF) DM1PRT6 MT DTT DM1PRT6 MA Inhibitor DM1PRT6 RN ClinicalTrials.gov (NCT03610646) Comparative Study to Evaluate the Efficacy and Safety of MYL-1701P and Eylea in Subjects With Diabetic Macular Edema. U.S. National Institutes of Health. DM1PRT6 RU https://clinicaltrials.gov/ct2/show/NCT03610646 DM8D13S DI DM8D13S DM8D13S DN MABp1 DM8D13S MI TTPM6HI DM8D13S MN Interleukin-1 alpha (IL1A) DM8D13S MT DTT DM8D13S MA Inhibitor DM8D13S RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DM8D13S RU http://phrma-docs.phrma.org/files/dmfile/MID_Skin_Diseases_2018_9_FINAL.pdf DMVXUR0 DI DMVXUR0 DMVXUR0 DN Magrolimab DMVXUR0 MI TTN2JFW DMVXUR0 MN T-cell surface glycoprotein CD4 (CD4) DMVXUR0 MT DTT DMVXUR0 MA Inhibitor DMVXUR0 RN Current and emerging strategies for management of myelodysplastic syndromes. Blood Rev. 2021 Jul;48:100791. DMVXUR0 RU https://pubmed.ncbi.nlm.nih.gov/33423844 DMJPGUA DI DMJPGUA DMJPGUA DN Manidipine DMJPGUA MI DERSX5P DMJPGUA MN Cytochrome P450 2J2 (CYP2J2) DMJPGUA MT DME DMJPGUA MA Metabolism DMJPGUA RN Inhibitory effects of antihypertensive drugs on human cytochrome P450 2J2 activity: Potent inhibition by azelnidipine and manidipine. Chem Biol Interact. 2019 Jun 1;306:1-9. DMJPGUA RU https://www.ncbi.nlm.nih.gov/pubmed/?term=30965050 DMJPGUA DI DMJPGUA DMJPGUA DN Manidipine DMJPGUA MI DE4LYSA DMJPGUA MN Cytochrome P450 3A4 (CYP3A4) DMJPGUA MT DME DMJPGUA MA Metabolism DMJPGUA RN Effect of grapefruit juice on the disposition of manidipine enantiomers in healthy subjects. Br J Clin Pharmacol. 2006 May;61(5):533-7. DMJPGUA RU https://www.ncbi.nlm.nih.gov/pubmed/?term=16669846 DMJPGUA DI DMJPGUA DMJPGUA DN Manidipine DMJPGUA MI TTEAID7 DMJPGUA MN Trypanosoma Cruzipain (Trypano CYSP) DMJPGUA MT DTT DMJPGUA MA Inhibitor DMJPGUA RN Colloid formation by drugs in simulated intestinal fluid. J Med Chem. 2010 May 27;53(10):4259-65. DMJPGUA RU https://pubmed.ncbi.nlm.nih.gov/20426472 DMR23M1 DI DMR23M1 DMR23M1 DN Mapracorat DMR23M1 MI TTYRL6O DMR23M1 MN Glucocorticoid receptor (NR3C1) DMR23M1 MT DTT DMR23M1 MA Agonist DMR23M1 RN Characterization of ZK 245186, a novel, selective glucocorticoid receptor agonist for the topical treatment of inflammatory skin diseases. Br J Pharmacol. 2009 Oct;158(4):1088-103. DMR23M1 RU https://pubmed.ncbi.nlm.nih.gov/19422381 DMJCF1O DI DMJCF1O DMJCF1O DN Maralixibat DMJCF1O MI TTPI1M5 DMJCF1O MN Ileal sodium/bile acid cotransporter (SLC10A2) DMJCF1O MT DTT DMJCF1O MA Inhibitor DMJCF1O RN Ileal bile acid transporter inhibition as an anticholestatic therapeutic target in biliary atresia and other cholestatic disorders. Hepatol Int. 2020 Sep;14(5):677-689. DMJCF1O RU https://pubmed.ncbi.nlm.nih.gov/32653991 DM3GTAL DI DM3GTAL DM3GTAL DN Maribavir DM3GTAL MI DE4LYSA DM3GTAL MN Cytochrome P450 3A4 (CYP3A4) DM3GTAL MT DME DM3GTAL MA Metabolism DM3GTAL RN Maribavir pharmacokinetics and the effects of multiple-dose maribavir on cytochrome P450 (CYP) 1A2, CYP 2C9, CYP 2C19, CYP 2D6, CYP 3A, N-acetyltransferase-2, and xanthine oxidase activities in healthy adults. Antimicrob Agents Chemother. 2006 Apr;50(4):1130-5. DM3GTAL RU https://www.ncbi.nlm.nih.gov/pubmed/?term=16569820 DM3GTAL DI DM3GTAL DM3GTAL DN Maribavir DM3GTAL MI TTXQ04B DM3GTAL MN Cytomegalovirus Ganciclovir kinase (CMV UL97) DM3GTAL MT DTT DM3GTAL MA Inhibitor DM3GTAL RN The human cytomegalovirus UL97 protein kinase, an antiviral drug target, is required at the stage of nuclear egress. J Virol. 2003 Jan;77(2):905-14. DM3GTAL RU https://pubmed.ncbi.nlm.nih.gov/12502806 DM6V34C DI DM6V34C DM6V34C DN Marimastat DM6V34C MI TTMX39J DM6V34C MN Matrix metalloproteinase-1 (MMP-1) DM6V34C MT DTT DM6V34C MA Inhibitor DM6V34C RN Metalloelastase (MMP-12) induced inflammatory response in mice airways: effects of dexamethasone, rolipram and marimastat. Eur J Pharmacol. 2007 Mar 15;559(1):75-81. DM6V34C RU https://pubmed.ncbi.nlm.nih.gov/17234180 DM6V34C DI DM6V34C DM6V34C DN Marimastat DM6V34C MI TTLM12X DM6V34C MN Matrix metalloproteinase-2 (MMP-2) DM6V34C MT DTT DM6V34C MA Inhibitor DM6V34C RN Metalloelastase (MMP-12) induced inflammatory response in mice airways: effects of dexamethasone, rolipram and marimastat. Eur J Pharmacol. 2007 Mar 15;559(1):75-81. DM6V34C RU https://pubmed.ncbi.nlm.nih.gov/17234180 DM6V34C DI DM6V34C DM6V34C DN Marimastat DM6V34C MI TTMTWOS DM6V34C MN Matrix metalloproteinase-7 (MMP-7) DM6V34C MT DTT DM6V34C MA Inhibitor DM6V34C RN Metalloelastase (MMP-12) induced inflammatory response in mice airways: effects of dexamethasone, rolipram and marimastat. Eur J Pharmacol. 2007 Mar 15;559(1):75-81. DM6V34C RU https://pubmed.ncbi.nlm.nih.gov/17234180 DME9QGW DI DME9QGW DME9QGW DN Marizomib DME9QGW MI TTU7ZMG DME9QGW MN Proteasome (PS) DME9QGW MT DTT DME9QGW MA Inhibitor DME9QGW RN Marizomib, a proteasome inhibitor for all seasons: preclinical profile and a framework for clinical trials. Curr Cancer Drug Targets. 2011 Mar;11(3):254-84. DME9QGW RU https://pubmed.ncbi.nlm.nih.gov/21247382 DMRSNEU DI DMRSNEU DMRSNEU DN Masitinib DMRSNEU MI TT6PKBN DMRSNEU MN Proto-oncogene c-Src (SRC) DMRSNEU MT DTT DMRSNEU MA Inhibitor DMRSNEU RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMRSNEU RU http://phrma-docs.phrma.org/files/dmfile/medicines-in-development-drug-list-autoimmune-diseases.pdf DMRSNEU DI DMRSNEU DMRSNEU DN Masitinib DMRSNEU MI TTJSQEF DMRSNEU MN Tyrosine-protein kinase (PTK) DMRSNEU MT DTT DMRSNEU MA Inhibitor DMRSNEU RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMRSNEU RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DMK9BP2 DI DMK9BP2 DMK9BP2 DN Mavacamten DMK9BP2 MI TTITSMB DMK9BP2 MN Myosin (MYO) DMK9BP2 MT DTT DMK9BP2 MA Inhibitor DMK9BP2 RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMK9BP2 RU http://phrma-docs.phrma.org/files/dmfile/2018_Heart-Disease-and-Stroke_MID-Drug-List.pdf DMBPY9Z DI DMBPY9Z DMBPY9Z DN MBG453 DMBPY9Z MI TT1RWL7 DMBPY9Z MN Hepatitis A virus cellular receptor 2 (TIM3) DMBPY9Z MT DTT DMBPY9Z RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMBPY9Z RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DMVZ57G DI DMVZ57G DMVZ57G DN MD1003 DMVZ57G MI TTSXVID DMVZ57G MN Nuclear factor NF-kappa-B (NFKB) DMVZ57G MT DTT DMVZ57G MA Inhibitor DMVZ57G RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMVZ57G RU http://phrma-docs.phrma.org/files/dmfile/MID_Neurological-Disorders-Drug-List_2018.pdf DM5X849 DI DM5X849 DM5X849 DN MEDI4736 DM5X849 MI TT8ZLTI DM5X849 MN Programmed cell death 1 ligand 1 (PD-L1) DM5X849 MT DTT DM5X849 MA Modulator DM5X849 RN National Cancer Institute Drug Dictionary (drug id 740856). DM5X849 RU http://www.cancer.gov/publications/dictionaries/cancer-drug?cdrid=740856 DM4W8RE DI DM4W8RE DM4W8RE DN Melagatran DM4W8RE MI TT2WR1T DM4W8RE MN Cationic trypsinogen (PRSS1) DM4W8RE MT DTT DM4W8RE MA Inhibitor DM4W8RE RN Orally active thrombin inhibitors. Part 1: optimization of the P1-moiety. Bioorg Med Chem Lett. 2006 May 15;16(10):2641-7. DM4W8RE RU https://pubmed.ncbi.nlm.nih.gov/16517159 DM4W8RE DI DM4W8RE DM4W8RE DN Melagatran DM4W8RE MI TT6L509 DM4W8RE MN Coagulation factor IIa (F2) DM4W8RE MT DTT DM4W8RE MA Inhibitor DM4W8RE RN Orally active thrombin inhibitors. Part 2: optimization of the P2-moiety. Bioorg Med Chem Lett. 2006 May 15;16(10):2648-53. DM4W8RE RU https://pubmed.ncbi.nlm.nih.gov/16460939 DM4W8RE DI DM4W8RE DM4W8RE DN Melagatran DM4W8RE MI TTCIHJA DM4W8RE MN Coagulation factor Xa (F10) DM4W8RE MT DTT DM4W8RE MA Inhibitor DM4W8RE RN Orally active thrombin inhibitors. Part 1: optimization of the P1-moiety. Bioorg Med Chem Lett. 2006 May 15;16(10):2641-7. DM4W8RE RU https://pubmed.ncbi.nlm.nih.gov/16517159 DM4W8RE DI DM4W8RE DM4W8RE DN Melagatran DM4W8RE MI DTUGYRD DM4W8RE MN P-glycoprotein 1 (ABCB1) DM4W8RE MT DTP DM4W8RE MA Substrate DM4W8RE RN Human intestinal transporter database: QSAR modeling and virtual profiling of drug uptake, efflux and interactions. Pharm Res. 2013 Apr;30(4):996-1007. DM4W8RE RU https://doi.org/10.1007/s11095-012-0935-x DM4W8RE DI DM4W8RE DM4W8RE DN Melagatran DM4W8RE MI TTP86E2 DM4W8RE MN Plasminogen (PLG) DM4W8RE MT DTT DM4W8RE MA Inhibitor DM4W8RE RN Orally active thrombin inhibitors. Part 1: optimization of the P1-moiety. Bioorg Med Chem Lett. 2006 May 15;16(10):2641-7. DM4W8RE RU https://pubmed.ncbi.nlm.nih.gov/16517159 DMQEC6Z DI DMQEC6Z DMQEC6Z DN Melanoma vaccine DMQEC6Z MI TT362RB DMQEC6Z MN MART-1 melanoma antigen (MLANA) DMQEC6Z MT DTT DMQEC6Z RN National Cancer Institute Drug Dictionary (drug id 685201). DMQEC6Z RU http://www.cancer.gov/publications/dictionaries/cancer-drug?cdrid=685201 DMQEC6Z DI DMQEC6Z DMQEC6Z DN Melanoma vaccine DMQEC6Z MI TT8MK59 DMQEC6Z MN Melanocytes lineage-specific antigen GP100 (PMEL) DMQEC6Z MT DTT DMQEC6Z RN National Cancer Institute Drug Dictionary (drug id 685201). DMQEC6Z RU http://www.cancer.gov/publications/dictionaries/cancer-drug?cdrid=685201 DMQEC6Z DI DMQEC6Z DMQEC6Z DN Melanoma vaccine DMQEC6Z MI TTULVH8 DMQEC6Z MN Tyrosinase (TYR) DMQEC6Z MT DTT DMQEC6Z RN National Cancer Institute Drug Dictionary (drug id 685201). DMQEC6Z RU http://www.cancer.gov/publications/dictionaries/cancer-drug?cdrid=685201 DM8Z0I3 DI DM8Z0I3 DM8Z0I3 DN MF-101 DM8Z0I3 MI TTOM3J0 DM8Z0I3 MN Estrogen receptor beta (ESR2) DM8Z0I3 MT DTT DM8Z0I3 MA Antagonist DM8Z0I3 RN MF101, a selective estrogen receptor beta modulator for the treatment of menopausal hot flushes: a phase II clinical trial. Menopause. 2009 May-Jun;16(3):458-65. DM8Z0I3 RU https://pubmed.ncbi.nlm.nih.gov/19182698 DMRKTCP DI DMRKTCP DMRKTCP DN MGA012 DMRKTCP MI TTNBFWK DMRKTCP MN Programmed cell death protein 1 (PD-1) DMRKTCP MT DTT DMRKTCP MA Inhibitor DMRKTCP RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMRKTCP RU http://phrma-docs.phrma.org/files/dmfile/MID_Immuno-Oncology-2017_Drug-List1.pdf DMCJRL1 DI DMCJRL1 DMCJRL1 DN MGN-1703 DMCJRL1 MI TTSHG0T DMCJRL1 MN Toll-like receptor 9 (TLR9) DMCJRL1 MT DTT DMCJRL1 MA Agonist DMCJRL1 RN Maintenance treatment with the immunomodulator MGN1703, a Toll-like receptor 9 (TLR9) agonist, in patients with metastatic colorectal carcinoma and disease control after chemotherapy: a randomised, double-blind, placebo-controlled trial. J Cancer Res Clin Oncol. 2014 Sep;140(9):1615-24. DMCJRL1 RU https://pubmed.ncbi.nlm.nih.gov/24816725 DMZHN5B DI DMZHN5B DMZHN5B DN MIM-D3 DMZHN5B MI TTTDVOJ DMZHN5B MN Tropomyosin-related kinase A (TrkA) DMZHN5B MT DTT DMZHN5B MA Agonist DMZHN5B RN Safety and efficacy of MIM-D3 ophthalmic solutions in a randomized, placebo-controlled Phase 2 clinical trial in patients with dry eye. Clin Ophthalmol. 2013; 7: 1275-1285. DMZHN5B RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3699314/ DMCJY35 DI DMCJY35 DMCJY35 DN MIN-101 DMCJY35 MI TTJQOD7 DMCJY35 MN 5-HT 2A receptor (HTR2A) DMCJY35 MT DTT DMCJY35 MA Antagonist DMCJY35 RN Pharmacological profile of the new potent neuroleptic ocaperidone (R 79,598). J Pharmacol Exp Ther. 1992 Jan;260(1):146-59. DMCJY35 RU https://pubmed.ncbi.nlm.nih.gov/1370538 DMCJY35 DI DMCJY35 DMCJY35 DN MIN-101 DMCJY35 MI TT9NXW4 DMCJY35 MN Sigma intracellular receptor 2 (TMEM97) DMCJY35 MT DTT DMCJY35 MA Antagonist DMCJY35 RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMCJY35 RU http://phrma-docs.phrma.org/files/dmfile/MID_Mental-Illness-2017-Drug-List_Final.pdf DM7R3N5 DI DM7R3N5 DM7R3N5 DN Mirikizumab DM7R3N5 MI TTRTK6Y DM7R3N5 MN Interleukin-12 alpha (IL12A) DM7R3N5 MT DTT DM7R3N5 MA Inhibitor DM7R3N5 RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DM7R3N5 RU http://phrma-docs.phrma.org/files/dmfile/MID_Skin_Diseases_2018_9_FINAL.pdf DM5S4LX DI DM5S4LX DM5S4LX DN Mirvetuximab soravtansine DM5S4LX MI TTVC37M DM5S4LX MN Folate receptor alpha (FOLR1) DM5S4LX MT DTT DM5S4LX MA Antagonist DM5S4LX RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DM5S4LX RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DM3PSUF DI DM3PSUF DM3PSUF DN MK-3102 DM3PSUF MI TTDIGC1 DM3PSUF MN Dipeptidyl peptidase 4 (DPP-4) DM3PSUF MT DTT DM3PSUF MA Modulator DM3PSUF RN Omarigliptin (MK-3102): a novel long-acting DPP-4 inhibitor for once-weekly treatment of type 2 diabetes. J Med Chem. 2014 Apr 24;57(8):3205-12. DM3PSUF RU https://pubmed.ncbi.nlm.nih.gov/24660890 DMQBF7O DI DMQBF7O DMQBF7O DN MK-3222 DMQBF7O MI TTC1GLB DMQBF7O MN Interleukin-23 (IL23) DMQBF7O MT DTT DMQBF7O RN Tildrakizumab (MK-3222), an anti-interleukin-23p19 monoclonal antibody, improves psoriasis in a phase IIb randomized placebo-controlled trial. Br J Dermatol. 2015 Oct;173(4):930-9. DMQBF7O RU https://pubmed.ncbi.nlm.nih.gov/26042589 DMGNHC2 DI DMGNHC2 DMGNHC2 DN MK-3415A DMGNHC2 MI TT64H8L DMGNHC2 MN Clostridium difficile Toxin A (CD toxA) DMGNHC2 MT DTT DMGNHC2 RN ClinicalTrials.gov (NCT01513239) A Study of MK-6072 and MK-3415A in Participants Receiving Antibiotic Therapy for Clostridium Difficile Infection (MK-3415A-002). U.S. National Institutes of Health. DMGNHC2 RU https://clinicaltrials.gov/ct2/show/NCT01513239 DMGNHC2 DI DMGNHC2 DMGNHC2 DN MK-3415A DMGNHC2 MI TTQH65V DMGNHC2 MN Clostridium difficile Toxin B (CD toxB) DMGNHC2 MT DTT DMGNHC2 RN ClinicalTrials.gov (NCT01513239) A Study of MK-6072 and MK-3415A in Participants Receiving Antibiotic Therapy for Clostridium Difficile Infection (MK-3415A-002). U.S. National Institutes of Health. DMGNHC2 RU https://clinicaltrials.gov/ct2/show/NCT01513239 DMA25NO DI DMA25NO DMA25NO DN MK-4214 DMA25NO MI TT5TQ2W DMA25NO MN Granulocyte colony-stimulating factor (CSF3) DMA25NO MT DTT DMA25NO MA Modulator DMA25NO RN DOI: 10.1038/nbt0710-636a DMA25NO RU http://www.nature.com/nbt/journal/v28/n7/full/nbt0710-636a.html DMLYGH4 DI DMLYGH4 DMLYGH4 DN MK-4827 DMLYGH4 MI DEP54UE DMLYGH4 MN Beta-glucuronidase (GUSB) DMLYGH4 MT DME DMLYGH4 MA Metabolism DMLYGH4 RN Summary of FDA-approved anticancer cytotoxic drugs at May 2019. DMLYGH4 RU https://www.mdpi.com/2073-4409/8/9/1013/s1 DMLYGH4 DI DMLYGH4 DMLYGH4 DN MK-4827 DMLYGH4 MI DEB30C5 DMLYGH4 MN Carboxylesterase 1 (CES1) DMLYGH4 MT DME DMLYGH4 MA Metabolism DMLYGH4 RN Summary of FDA-approved anticancer cytotoxic drugs at May 2019. DMLYGH4 RU https://www.mdpi.com/2073-4409/8/9/1013/s1 DMLYGH4 DI DMLYGH4 DMLYGH4 DN MK-4827 DMLYGH4 MI DE6OQ3W DMLYGH4 MN Cytochrome P450 1A1 (CYP1A1) DMLYGH4 MT DME DMLYGH4 MA Metabolism DMLYGH4 RN Discovery of 2-{4-[(3S)-piperidin-3-yl]phenyl}-2H-indazole-7-carboxamide (MK-4827): a novel oral poly(ADP-ribose)polymerase (PARP) inhibitor efficacious in BRCA-1 and -2 mutant tumors. J Med Chem. 2009 Nov 26;52(22):7170-85. DMLYGH4 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=19873981 DMLYGH4 DI DMLYGH4 DMLYGH4 DN MK-4827 DMLYGH4 MI TTEBCY8 DMLYGH4 MN Poly [ADP-ribose] polymerase (PARP) DMLYGH4 MT DTT DMLYGH4 MA Modulator DMLYGH4 RN Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41. DMLYGH4 RU https://www.ncbi.nlm.nih.gov/pubmed/15950434 DM84LO5 DI DM84LO5 DM84LO5 DN MK-8109 DM84LO5 MI TTVC37M DM84LO5 MN Folate receptor alpha (FOLR1) DM84LO5 MT DTT DM84LO5 MA Modulator DM84LO5 RN A current review of folate receptor alpha as a potential tumor target in non-small-cell lung cancer. Drug Des Devel Ther. 2015; 9: 4989-4996. DM84LO5 RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4560517/ DMK301H DI DMK301H DMK301H DN MK-8742 DMK301H MI TTCJ2X8 DMK301H MN Hepatitis C virus Non-structural 5A (HCV NS5A) DMK301H MT DTT DMK301H MA Modulator DMK301H RN Discovery of MK-8742: an HCV NS5A inhibitor with broad genotype activity. ChemMedChem. 2013 Dec;8(12):1930-40. DMK301H RU https://pubmed.ncbi.nlm.nih.gov/24127258 DMT8IAJ DI DMT8IAJ DMT8IAJ DN MK-8808 DMT8IAJ MI TTUE541 DMT8IAJ MN Leukocyte surface antigen Leu-16 (CD20) DMT8IAJ MT DTT DMT8IAJ MA Agonist DMT8IAJ RN Rituximab (monoclonal anti-CD20 antibody): mechanisms of action and resistance. Oncogene. 2003 Oct 20;22(47):7359-68. DMT8IAJ RU https://pubmed.ncbi.nlm.nih.gov/14576843 DMP36KD DI DMP36KD DMP36KD DN MLN4924 DMP36KD MI TTVKOPM DMP36KD MN NEDD8-activating enzyme (NAE) DMP36KD MT DTT DMP36KD MA Modulator DMP36KD RN Targeting Cullin-RING ligases by MLN4924 induces autophagy via modulating the HIF1-REDD1-TSC1-mTORC1-DEPTOR axis.Cell Death Dis.2012 Sep 6;3:e386. DMP36KD RU https://www.ncbi.nlm.nih.gov/pubmed/22951983 DMP36KD DI DMP36KD DMP36KD DN MLN4924 DMP36KD MI TTNDC4K DMP36KD MN Ubiquitin-like protein Nedd8 (NEDD8) DMP36KD MT DTT DMP36KD MA Inhibitor DMP36KD RN Promoting tumorigenesis in nasopharyngeal carcinoma, NEDD8 serves as a potential theranostic target.Cell Death Dis. 2017 Jun 1;8(6):e2834. DMP36KD RU https://pubmed.ncbi.nlm.nih.gov/28569775 DMO8PT9 DI DMO8PT9 DMO8PT9 DN MLN8237 DMO8PT9 MI TTPS3C0 DMO8PT9 MN Aurora kinase A (AURKA) DMO8PT9 MT DTT DMO8PT9 MA Inhibitor DMO8PT9 RN Effect of Aurora A kinase inhibitor MLN8237 combined with rituximab on antitumor activity in preclinical B-cell non-Hodgkin's lymphoma models. Journal of Clinical Oncology, 2009:8553. DMO8PT9 RU http://meeting.ascopubs.org/cgi/content/abstract/27/15S/8553 DMFWE9S DI DMFWE9S DMFWE9S DN Mobocertinib DMFWE9S MI TT2M7YX DMFWE9S MN EGFR Exon20ins mutant (EGFR Exon20ins) DMFWE9S MT DTT DMFWE9S MA Inhibitor DMFWE9S RN Mobocertinib (TAK-788): A Targeted Inhibitor of EGFR Exon 20 Insertion Mutants in Non-Small Cell Lung Cancer. Cancer Discov. 2021 Feb 25;candisc.1683.2020. DMFWE9S RU https://pubmed.ncbi.nlm.nih.gov/33632773 DM2TNJ1 DI DM2TNJ1 DM2TNJ1 DN Molgramostim DM2TNJ1 MI TT6MP2Z DM2TNJ1 MN GMCSFR-alpha (CSF2RA) DM2TNJ1 MT DTT DM2TNJ1 MA Agonist DM2TNJ1 RN Clinical pipeline report, company report or official report of gensci-china. DM2TNJ1 RU http://www.gensci-china.com/gensci/cp1_somatropinAQ.asp?MaxID=3 DMF98Q0 DI DMF98Q0 DMF98Q0 DN Momelotinib DMF98Q0 MI DEJGDUW DMF98Q0 MN Cytochrome P450 1A2 (CYP1A2) DMF98Q0 MT DME DMF98Q0 MA Metabolism DMF98Q0 RN Pharmacokinetics and disposition of momelotinib revealed a disproportionate human metabolite-resolution for clinical development. Drug Metab Dispos. 2018 Mar;46(3):237-247. DMF98Q0 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=29311136 DMF98Q0 DI DMF98Q0 DMF98Q0 DN Momelotinib DMF98Q0 MI DES5XRU DMF98Q0 MN Cytochrome P450 2C8 (CYP2C8) DMF98Q0 MT DME DMF98Q0 MA Metabolism DMF98Q0 RN Pharmacokinetics and disposition of momelotinib revealed a disproportionate human metabolite-resolution for clinical development. Drug Metab Dispos. 2018 Mar;46(3):237-247. DMF98Q0 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=29311136 DMF98Q0 DI DMF98Q0 DMF98Q0 DN Momelotinib DMF98Q0 MI DE5IED8 DMF98Q0 MN Cytochrome P450 2C9 (CYP2C9) DMF98Q0 MT DME DMF98Q0 MA Metabolism DMF98Q0 RN Pharmacokinetics and disposition of momelotinib revealed a disproportionate human metabolite-resolution for clinical development. Drug Metab Dispos. 2018 Mar;46(3):237-247. DMF98Q0 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=29311136 DMF98Q0 DI DMF98Q0 DMF98Q0 DN Momelotinib DMF98Q0 MI DE4LYSA DMF98Q0 MN Cytochrome P450 3A4 (CYP3A4) DMF98Q0 MT DME DMF98Q0 MA Metabolism DMF98Q0 RN Pharmacokinetics and disposition of momelotinib revealed a disproportionate human metabolite-resolution for clinical development. Drug Metab Dispos. 2018 Mar;46(3):237-247. DMF98Q0 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=29311136 DMF98Q0 DI DMF98Q0 DMF98Q0 DN Momelotinib DMF98Q0 MI TTRMX3V DMF98Q0 MN Janus kinase 2 (JAK-2) DMF98Q0 MT DTT DMF98Q0 MA Modulator DMF98Q0 RN Genetic determinants of response and survival in momelotinib-treated patients with myelofibrosis.Leukemia.2015 Mar;29(3):741-4. DMF98Q0 RU https://www.ncbi.nlm.nih.gov/pubmed/25322686 DMF98Q0 DI DMF98Q0 DMF98Q0 DN Momelotinib DMF98Q0 MI DEGTFWK DMF98Q0 MN Mephenytoin 4-hydroxylase (CYP2C19) DMF98Q0 MT DME DMF98Q0 MA Metabolism DMF98Q0 RN Pharmacokinetics and disposition of momelotinib revealed a disproportionate human metabolite-resolution for clinical development. Drug Metab Dispos. 2018 Mar;46(3):237-247. DMF98Q0 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=29311136 DMQ1FU8 DI DMQ1FU8 DMQ1FU8 DN Montelukast DMQ1FU8 MI TTSB6CA DMQ1FU8 MN HUMAN cysteinyl leukotriene receptor (CysLTR) DMQ1FU8 MT DTT DMQ1FU8 MA Antagonist DMQ1FU8 RN As a potential treatment of COVID-19: Montelukast. Med Hypotheses. 2020 May 11;142:109828. DMQ1FU8 RU https://pubmed.ncbi.nlm.nih.gov/32416408 DMPVW6H DI DMPVW6H DMPVW6H DN Morphine-6-glucuronide DMPVW6H MI TTKWM86 DMPVW6H MN Opioid receptor mu (MOP) DMPVW6H MT DTT DMPVW6H MA Agonist DMPVW6H RN Emerging analgesics in cancer pain management. Expert Opin Emerg Drugs. 2005 Feb;10(1):151-71. DMPVW6H RU https://pubmed.ncbi.nlm.nih.gov/15757410 DMPVW6H DI DMPVW6H DMPVW6H DN Morphine-6-glucuronide DMPVW6H MI DTUGYRD DMPVW6H MN P-glycoprotein 1 (ABCB1) DMPVW6H MT DTP DMPVW6H MA Substrate DMPVW6H RN Human intestinal transporter database: QSAR modeling and virtual profiling of drug uptake, efflux and interactions. Pharm Res. 2013 Apr;30(4):996-1007. DMPVW6H RU https://doi.org/10.1007/s11095-012-0935-x DM15ZIB DI DM15ZIB DM15ZIB DN Mosunetuzumab DM15ZIB MI TTUE541 DM15ZIB MN Leukocyte surface antigen Leu-16 (CD20) DM15ZIB MT DTT DM15ZIB MA Inhibitor DM15ZIB RN Mitigating the risk of cytokine release syndrome in a Phase I trial of CD20/CD3 bispecific antibody mosunetuzumab in NHL: impact of translational system modeling. NPJ Syst Biol Appl. 2020 Aug 28;6(1):28. DM15ZIB RU https://pubmed.ncbi.nlm.nih.gov/32859946 DM15ZIB DI DM15ZIB DM15ZIB DN Mosunetuzumab DM15ZIB MI TTUN7MC DM15ZIB MN T-cell surface glycoprotein CD3 (CD3) DM15ZIB MT DTT DM15ZIB MA Inhibitor DM15ZIB RN Mitigating the risk of cytokine release syndrome in a Phase I trial of CD20/CD3 bispecific antibody mosunetuzumab in NHL: impact of translational system modeling. NPJ Syst Biol Appl. 2020 Aug 28;6(1):28. DM15ZIB RU https://pubmed.ncbi.nlm.nih.gov/32859946 DMB24H7 DI DMB24H7 DMB24H7 DN Motavizumab DMB24H7 MI TT57ID8 DMB24H7 MN Respiratory syncytial virus protein F (RSV F) DMB24H7 MT DTT DMB24H7 MA Modulator DMB24H7 RN Motavizumab. Correction in: MAbs. 2010 Sep-Oct; 2(5): 591. DMB24H7 RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2759493/ DM8K5Z6 DI DM8K5Z6 DM8K5Z6 DN Motexafin lutetium DM8K5Z6 MI TTS78AZ DM8K5Z6 MN Prostate specific antigen (KLK3) DM8K5Z6 MT DTT DM8K5Z6 MA Modulator DM8K5Z6 RN Motexafin lutetium-photodynamic therapy of prostate cancer: short- and long-term effects on prostate-specific antigen. Clin Cancer Res. 2008 Aug 1;14(15):4869-76. DM8K5Z6 RU https://pubmed.ncbi.nlm.nih.gov/18676760 DM9K3LM DI DM9K3LM DM9K3LM DN MPDL-3280A DM9K3LM MI TT8ZLTI DM9K3LM MN Programmed cell death 1 ligand 1 (PD-L1) DM9K3LM MT DTT DM9K3LM MA Modulator DM9K3LM RN Targeted immunotherapy for non-small cell lung cancer. World J Clin Oncol. 2014 May 10; 5(2): 39-47. DM9K3LM RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4014795/ DMNDCFY DI DMNDCFY DMNDCFY DN MPL-S DMNDCFY MI TTF10I9 DMNDCFY MN Nitric-oxide synthase inducible (NOS2) DMNDCFY MT DTT DMNDCFY MA Modulator DMNDCFY RN Lipopolysaccharide and monophosphoryl lipid A differentially regulate interleukin-12, gamma interferon, and interleukin-10 mRNA production in murine macrophages. Infect Immun. 1997 Aug;65(8):3239-47. DMNDCFY RU https://pubmed.ncbi.nlm.nih.gov/9234781 DMDV4EP DI DMDV4EP DMDV4EP DN MRTX849 DMDV4EP MI TT3LH46 DMDV4EP MN KRAS G12C mutant (KRAS G12C) DMDV4EP MT DTT DMDV4EP MA Inhibitor DMDV4EP RN Clinical pipeline report, company report or official report of Mirati Therapeutics. DMDV4EP RU https://www.mirati.com/science/pipeline/ DMUNBMA DI DMUNBMA DMUNBMA DN MT-1621 DMUNBMA MI TT7KNZQ DMUNBMA MN Thymidine kinase 2 (Mt-TK2) DMUNBMA MT DTT DMUNBMA MA Replacement DMUNBMA RN Clinical pipeline report, company report or official report of Modis Therapeutics. DMUNBMA RU https://www.modistx.com/product/ DMZPEHY DI DMZPEHY DMZPEHY DN Multi-epitope peptide melanoma vaccine DMZPEHY MI TT362RB DMZPEHY MN MART-1 melanoma antigen (MLANA) DMZPEHY MT DTT DMZPEHY RN Safety and immunogenicity of vaccination with MART-1 (26-35, 27L), gp100 (209-217, 210M), and tyrosinase (368-376, 370D) in-adjuvant with PF-3512676 and GM-CSF in metastatic melanoma. Correction in: volume 35 on page 650. DMZPEHY RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3483091/ DMZPEHY DI DMZPEHY DMZPEHY DN Multi-epitope peptide melanoma vaccine DMZPEHY MI TT8MK59 DMZPEHY MN Melanocytes lineage-specific antigen GP100 (PMEL) DMZPEHY MT DTT DMZPEHY RN Safety and immunogenicity of vaccination with MART-1 (26-35, 27L), gp100 (209-217, 210M), and tyrosinase (368-376, 370D) in-adjuvant with PF-3512676 and GM-CSF in metastatic melanoma. Correction in: volume 35 on page 650. DMZPEHY RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3483091/ DMZPEHY DI DMZPEHY DMZPEHY DN Multi-epitope peptide melanoma vaccine DMZPEHY MI TTULVH8 DMZPEHY MN Tyrosinase (TYR) DMZPEHY MT DTT DMZPEHY RN Safety and immunogenicity of vaccination with MART-1 (26-35, 27L), gp100 (209-217, 210M), and tyrosinase (368-376, 370D) in-adjuvant with PF-3512676 and GM-CSF in metastatic melanoma. Correction in: volume 35 on page 650. DMZPEHY RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3483091/ DMG3NFZ DI DMG3NFZ DMG3NFZ DN Muraglitazar DMG3NFZ MI DES5XRU DMG3NFZ MN Cytochrome P450 2C8 (CYP2C8) DMG3NFZ MT DME DMG3NFZ MA Metabolism DMG3NFZ RN Involvement of multiple cytochrome P450 and UDP-glucuronosyltransferase enzymes in the in vitro metabolism of muraglitazar. Drug Metab Dispos. 2007 Jan;35(1):139-49. DMG3NFZ RU https://www.ncbi.nlm.nih.gov/pubmed/?term=17062778 DMG3NFZ DI DMG3NFZ DMG3NFZ DN Muraglitazar DMG3NFZ MI DE5IED8 DMG3NFZ MN Cytochrome P450 2C9 (CYP2C9) DMG3NFZ MT DME DMG3NFZ MA Metabolism DMG3NFZ RN Involvement of multiple cytochrome P450 and UDP-glucuronosyltransferase enzymes in the in vitro metabolism of muraglitazar. Drug Metab Dispos. 2007 Jan;35(1):139-49. DMG3NFZ RU https://www.ncbi.nlm.nih.gov/pubmed/?term=17062778 DMG3NFZ DI DMG3NFZ DMG3NFZ DN Muraglitazar DMG3NFZ MI DECB0K3 DMG3NFZ MN Cytochrome P450 2D6 (CYP2D6) DMG3NFZ MT DME DMG3NFZ MA Metabolism DMG3NFZ RN Involvement of multiple cytochrome P450 and UDP-glucuronosyltransferase enzymes in the in vitro metabolism of muraglitazar. Drug Metab Dispos. 2007 Jan;35(1):139-49. DMG3NFZ RU https://www.ncbi.nlm.nih.gov/pubmed/?term=17062778 DMG3NFZ DI DMG3NFZ DMG3NFZ DN Muraglitazar DMG3NFZ MI DE4LYSA DMG3NFZ MN Cytochrome P450 3A4 (CYP3A4) DMG3NFZ MT DME DMG3NFZ MA Metabolism DMG3NFZ RN Involvement of multiple cytochrome P450 and UDP-glucuronosyltransferase enzymes in the in vitro metabolism of muraglitazar. Drug Metab Dispos. 2007 Jan;35(1):139-49. DMG3NFZ RU https://www.ncbi.nlm.nih.gov/pubmed/?term=17062778 DMG3NFZ DI DMG3NFZ DMG3NFZ DN Muraglitazar DMG3NFZ MI DEGTFWK DMG3NFZ MN Mephenytoin 4-hydroxylase (CYP2C19) DMG3NFZ MT DME DMG3NFZ MA Metabolism DMG3NFZ RN Involvement of multiple cytochrome P450 and UDP-glucuronosyltransferase enzymes in the in vitro metabolism of muraglitazar. Drug Metab Dispos. 2007 Jan;35(1):139-49. DMG3NFZ RU https://www.ncbi.nlm.nih.gov/pubmed/?term=17062778 DMG3NFZ DI DMG3NFZ DMG3NFZ DN Muraglitazar DMG3NFZ MI TTJ584C DMG3NFZ MN Peroxisome proliferator-activated receptor alpha (PPARA) DMG3NFZ MT DTT DMG3NFZ MA Modulator DMG3NFZ RN Muraglitazar, a dual (alpha/gamma) PPAR activator: a randomized, double-blind, placebo-controlled, 24-week monotherapy trial in adult patients with... Clin Ther. 2005 Aug;27(8):1181-95. DMG3NFZ RU https://www.ncbi.nlm.nih.gov/pubmed/16199244 DMG3NFZ DI DMG3NFZ DMG3NFZ DN Muraglitazar DMG3NFZ MI TTZMAO3 DMG3NFZ MN Peroxisome proliferator-activated receptor gamma (PPAR-gamma) DMG3NFZ MT DTT DMG3NFZ MA Modulator DMG3NFZ RN Muraglitazar, a dual (alpha/gamma) PPAR activator: a randomized, double-blind, placebo-controlled, 24-week monotherapy trial in adult patients with... Clin Ther. 2005 Aug;27(8):1181-95. DMG3NFZ RU https://www.ncbi.nlm.nih.gov/pubmed/16199244 DMG3NFZ DI DMG3NFZ DMG3NFZ DN Muraglitazar DMG3NFZ MI DEYGVN4 DMG3NFZ MN UDP-glucuronosyltransferase 1A1 (UGT1A1) DMG3NFZ MT DME DMG3NFZ MA Metabolism DMG3NFZ RN Characterization of the UDP glucuronosyltransferase activity of human liver microsomes genotyped for the UGT1A1*28 polymorphism. Drug Metab Dispos. 2007 Dec;35(12):2270-80. DMG3NFZ RU https://www.ncbi.nlm.nih.gov/pubmed/?term=17898154 DMG3NFZ DI DMG3NFZ DMG3NFZ DN Muraglitazar DMG3NFZ MI DEF2WXN DMG3NFZ MN UDP-glucuronosyltransferase 1A3 (UGT1A3) DMG3NFZ MT DME DMG3NFZ MA Metabolism DMG3NFZ RN Characterization of the UDP glucuronosyltransferase activity of human liver microsomes genotyped for the UGT1A1*28 polymorphism. Drug Metab Dispos. 2007 Dec;35(12):2270-80. DMG3NFZ RU https://www.ncbi.nlm.nih.gov/pubmed/?term=17898154 DMG3NFZ DI DMG3NFZ DMG3NFZ DN Muraglitazar DMG3NFZ MI DE85D2P DMG3NFZ MN UDP-glucuronosyltransferase 1A9 (UGT1A9) DMG3NFZ MT DME DMG3NFZ MA Metabolism DMG3NFZ RN Involvement of multiple cytochrome P450 and UDP-glucuronosyltransferase enzymes in the in vitro metabolism of muraglitazar. Drug Metab Dispos. 2007 Jan;35(1):139-49. DMG3NFZ RU https://www.ncbi.nlm.nih.gov/pubmed/?term=17062778 DMUQ390 DI DMUQ390 DMUQ390 DN Murepavadin DMUQ390 MI TTJZ7GF DMUQ390 MN Pseudomonas LPS-assembly protein LptD (Pseudo lptD) DMUQ390 MT DTT DMUQ390 MA Antagonist DMUQ390 RN Anti-ageing pipeline starts to mature.Nat Rev Drug Discov. 2018 Sep;17(9):609-612. DMUQ390 RU https://pubmed.ncbi.nlm.nih.gov/30072728 DMS9GE1 DI DMS9GE1 DMS9GE1 DN MyoCell SDF-1 DMS9GE1 MI TT4UGTF DMS9GE1 MN Stromal cell-derived factor 1 (CXCL12) DMS9GE1 MT DTT DMS9GE1 MA Modulator DMS9GE1 RN Stromal cell-derived factor-1 (SDF-1): homing factor for engineered regenerative medicine. Expert Opin Biol Ther. 2011 Feb;11(2):189-97. DMS9GE1 RU https://pubmed.ncbi.nlm.nih.gov/21219236 DMY60DT DI DMY60DT DMY60DT DN N8-GP DMY60DT MI TT1290U DMY60DT MN Coagulation factor VIII (F8) DMY60DT MT DTT DMY60DT MA Modulator DMY60DT RN Enhancing the pharmacokinetic properties of recombinant factor VIII: first-in-human trial of glycoPEGylated recombinant factor VIII in patients with hemophilia A. J Thromb Haemost. 2013 Apr;11(4):670-8. DMY60DT RU https://pubmed.ncbi.nlm.nih.gov/23398640 DMHKJ5I DI DMHKJ5I DMHKJ5I DN Nabiximols DMHKJ5I MI DE5IED8 DMHKJ5I MN Cytochrome P450 2C9 (CYP2C9) DMHKJ5I MT DME DMHKJ5I MA Metabolism DMHKJ5I RN Molecular targets of cannabidiol in neurological disorders. Neurotherapeutics. 2015 Oct;12(4):699-730. DMHKJ5I RU https://www.ncbi.nlm.nih.gov/pubmed/?term=26264914 DMHKJ5I DI DMHKJ5I DMHKJ5I DN Nabiximols DMHKJ5I MI DECB0K3 DMHKJ5I MN Cytochrome P450 2D6 (CYP2D6) DMHKJ5I MT DME DMHKJ5I MA Metabolism DMHKJ5I RN Exogenous cannabinoids as substrates, inhibitors, and inducers of human drug metabolizing enzymes: a systematic review. Drug Metab Rev. 2014 Feb;46(1):86-95. DMHKJ5I RU https://www.ncbi.nlm.nih.gov/pubmed/?term=24160757 DMHKJ5I DI DMHKJ5I DMHKJ5I DN Nabiximols DMHKJ5I MI DE4LYSA DMHKJ5I MN Cytochrome P450 3A4 (CYP3A4) DMHKJ5I MT DME DMHKJ5I MA Metabolism DMHKJ5I RN Pharmacokinetic evaluation of nabiximols for the treatment of multiple sclerosis pain. Expert Opin Drug Metab Toxicol. 2013 Sep;9(9):1219-28. DMHKJ5I RU https://www.ncbi.nlm.nih.gov/pubmed/?term=23621668 DMHKJ5I DI DMHKJ5I DMHKJ5I DN Nabiximols DMHKJ5I MI DEIBDNY DMHKJ5I MN Cytochrome P450 3A5 (CYP3A5) DMHKJ5I MT DME DMHKJ5I MA Metabolism DMHKJ5I RN Exogenous cannabinoids as substrates, inhibitors, and inducers of human drug metabolizing enzymes: a systematic review. Drug Metab Rev. 2014 Feb;46(1):86-95. DMHKJ5I RU https://www.ncbi.nlm.nih.gov/pubmed/?term=24160757 DMHKJ5I DI DMHKJ5I DMHKJ5I DN Nabiximols DMHKJ5I MI DEGTFWK DMHKJ5I MN Mephenytoin 4-hydroxylase (CYP2C19) DMHKJ5I MT DME DMHKJ5I MA Metabolism DMHKJ5I RN Molecular targets of cannabidiol in neurological disorders. Neurotherapeutics. 2015 Oct;12(4):699-730. DMHKJ5I RU https://www.ncbi.nlm.nih.gov/pubmed/?term=26264914 DMDZ6Q3 DI DMDZ6Q3 DMDZ6Q3 DN Napabucasin DMDZ6Q3 MI TTH8FZW DMDZ6Q3 MN Signal transducer and activator of transcription 3 (STAT3) DMDZ6Q3 MT DTT DMDZ6Q3 MA Inhibitor DMDZ6Q3 RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMDZ6Q3 RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DMKP45D DI DMKP45D DMKP45D DN Naproxcinod DMKP45D MI TTK0943 DMKP45D MN Prostaglandin G/H synthase (COX) DMKP45D MT DTT DMKP45D MA Modulator DMKP45D RN Naproxcinod, a new cyclooxygenase-inhibiting nitric oxide donator (CINOD). Expert Opin Biol Ther. 2009 May;9(5):649-57. DMKP45D RU https://pubmed.ncbi.nlm.nih.gov/19392579 DMIC56X DI DMIC56X DMIC56X DN NASVAC DMIC56X MI TT6KSF7 DMIC56X MN Hepatitis B virus Large envelope protein (HBV S) DMIC56X MT DTT DMIC56X RN In vitro stimulation with HBV therapeutic vaccine candidate Nasvac activates B and T cells from chronic hepatitis B patients and healthy donors. Mol Immunol. 2015 Feb;63(2):320-7. DMIC56X RU https://pubmed.ncbi.nlm.nih.gov/25193323 DMIC56X DI DMIC56X DMIC56X DN NASVAC DMIC56X MI TTRF7Q8 DMIC56X MN Natural killer cell receptor (NKCR) DMIC56X MT DTT DMIC56X RN In vitro stimulation with HBV therapeutic vaccine candidate Nasvac activates B and T cells from chronic hepatitis B patients and healthy donors. Mol Immunol. 2015 Feb;63(2):320-7. DMIC56X RU https://pubmed.ncbi.nlm.nih.gov/25193323 DMRSI1M DI DMRSI1M DMRSI1M DN NAV5001 DMRSI1M MI TTVBI8W DMRSI1M MN Dopamine transporter (DAT) DMRSI1M MT DTT DMRSI1M MA Modulator DMRSI1M RN Rapid detection of Parkinson's disease by SPECT with altropane: a selective ligand for dopamine transporters. Synapse. 1998 Jun;29(2):128-41. DMRSI1M RU https://pubmed.ncbi.nlm.nih.gov/9593103 DMVO1C0 DI DMVO1C0 DMVO1C0 DN NBI-98854 DMVO1C0 MI DECB0K3 DMVO1C0 MN Cytochrome P450 2D6 (CYP2D6) DMVO1C0 MT DME DMVO1C0 MA Metabolism DMVO1C0 RN Tardive dyskinesia: placing vesicular monoamine transporter type 2 (VMAT2) inhibitors into clinical perspective. Expert Rev Neurother. 2018 Apr;18(4):323-332. DMVO1C0 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=29557243 DMVO1C0 DI DMVO1C0 DMVO1C0 DN NBI-98854 DMVO1C0 MI TTNZRI3 DMVO1C0 MN Synaptic vesicle amine transporter (SLC18A2) DMVO1C0 MT DTT DMVO1C0 MA Inhibitor DMVO1C0 RN NBI-98854, a selective monoamine transport inhibitor for the treatment of tardive dyskinesia: A randomized, double-blind, placebo-controlled study. Mov Disord. 2015 Oct;30(12):1681-7. DMVO1C0 RU https://pubmed.ncbi.nlm.nih.gov/26346941 DMFD249 DI DMFD249 DMFD249 DN Nebracetam DMFD249 MI TTZ9SOR DMFD249 MN Muscarinic acetylcholine receptor M1 (CHRM1) DMFD249 MT DTT DMFD249 MA Agonist DMFD249 RN Effects of nebracetam (WEB 1881 FU), a novel nootropic, as a M1-muscarinic agonist. Jpn J Pharmacol. 1991 Jan;55(1):177-80. DMFD249 RU https://pubmed.ncbi.nlm.nih.gov/2041225 DMDBY30 DI DMDBY30 DMDBY30 DN Nelipepimut S DMDBY30 MI TT6EO5L DMDBY30 MN Erbb2 tyrosine kinase receptor (HER2) DMDBY30 MT DTT DMDBY30 MA Inhibitor DMDBY30 RN The HER2 peptide nelipepimut-S (E75) vaccine (NeuVax in breast cancer patients at risk for recurrence: correlation of immunologic data with clinical response. Immunotherapy. 2014;6(5):519-31. DMDBY30 RU https://pubmed.ncbi.nlm.nih.gov/24896623 DMH9EUA DI DMH9EUA DMH9EUA DN Nemolizumab DMH9EUA MI TT9HPX0 DMH9EUA MN Interleukin 31 receptor (IL31R) DMH9EUA MT DTT DMH9EUA RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMH9EUA RU http://phrma-docs.phrma.org/files/dmfile/MID_Skin_Diseases_2018_9_FINAL.pdf DMIPNBG DI DMIPNBG DMIPNBG DN Nemonaxacin DMIPNBG MI TTIXTO3 DMIPNBG MN Staphylococcus Topoisomerase IV (Stap-coc parC) DMIPNBG MT DTT DMIPNBG MA Modulator DMIPNBG RN In vitro activity of nemonoxacin (TG-873870), a novel non-fluorinated quinolone, against clinical isolates of Staphylococcus aureus, enterococci and Streptococcus pneumoniae with various resistance phenotypes in Taiwan.J Antimicrob Chemother.2009 Dec;64(6):1226-9. DMIPNBG RU https://www.ncbi.nlm.nih.gov/pubmed/19833635 DMVP7HI DI DMVP7HI DMVP7HI DN Nestorone DMVP7HI MI TTUV8G9 DMVP7HI MN Progesterone receptor (PGR) DMVP7HI MT DTT DMVP7HI MA Agonist DMVP7HI RN Efficacy of the selective progesterone receptor agonist Nestorone for chronic experimental autoimmune encephalomyelitis. J Neuroimmunol. 2014 Nov 15;276(1-2):89-97. DMVP7HI RU https://pubmed.ncbi.nlm.nih.gov/25200475 DMTKRY1 DI DMTKRY1 DMTKRY1 DN Netivudine DMTKRY1 MI TTIU7X1 DMTKRY1 MN Herpes simplex virus DNA polymerase UL30 (HSV UL30) DMTKRY1 MT DTT DMTKRY1 MA Modulator DMTKRY1 RN Current pharmacological approaches to the therapy of varicella zoster virus infections: a guide to treatment. Drugs. 1999 Feb;57(2):187-206. DMTKRY1 RU https://pubmed.ncbi.nlm.nih.gov/10188760 DMEKAYI DI DMEKAYI DMEKAYI DN Netupitant DMEKAYI MI DE5IED8 DMEKAYI MN Cytochrome P450 2C9 (CYP2C9) DMEKAYI MT DME DMEKAYI MA Metabolism DMEKAYI RN Effect of netupitant, a highly selective NK?receptor antagonist, on the pharmacokinetics of palonosetron and impact of the fixed dose combination of netupitant and palonosetron when coadministered with ketoconazole, rifampicin, and oral contraceptives. Support Care Cancer. 2013 Oct;21(10):2879-87. DMEKAYI RU https://www.ncbi.nlm.nih.gov/pubmed/?term=23748441 DMEKAYI DI DMEKAYI DMEKAYI DN Netupitant DMEKAYI MI DECB0K3 DMEKAYI MN Cytochrome P450 2D6 (CYP2D6) DMEKAYI MT DME DMEKAYI MA Metabolism DMEKAYI RN Effect of netupitant, a highly selective NK?receptor antagonist, on the pharmacokinetics of palonosetron and impact of the fixed dose combination of netupitant and palonosetron when coadministered with ketoconazole, rifampicin, and oral contraceptives. Support Care Cancer. 2013 Oct;21(10):2879-87. DMEKAYI RU https://www.ncbi.nlm.nih.gov/pubmed/?term=23748441 DMEKAYI DI DMEKAYI DMEKAYI DN Netupitant DMEKAYI MI DE4LYSA DMEKAYI MN Cytochrome P450 3A4 (CYP3A4) DMEKAYI MT DME DMEKAYI MA Metabolism DMEKAYI RN Complementary pharmacokinetic profiles of netupitant and palonosetron support the rationale for their oral fixed combination for the prevention of chemotherapy-induced nausea and vomiting. J Clin Pharmacol. 2019 Apr;59(4):472-487. DMEKAYI RU https://www.ncbi.nlm.nih.gov/pubmed/?term=30412271 DMEKAYI DI DMEKAYI DMEKAYI DN Netupitant DMEKAYI MI TTZPO1L DMEKAYI MN Substance-P receptor (TACR1) DMEKAYI MT DTT DMEKAYI MA Antagonist DMEKAYI RN Netupitant and palonosetron trigger NK1 receptor internalization in NG108-15 cells. Exp Brain Res. 2014 Aug;232(8):2637-44. DMEKAYI RU https://pubmed.ncbi.nlm.nih.gov/24969614 DME617W DI DME617W DME617W DN Neucardin DME617W MI TTEH395 DME617W MN Pro-neuregulin-1 (Pro-NRG1) DME617W MT DTT DME617W MA Modulator DME617W RN Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41. DME617W RU https://www.ncbi.nlm.nih.gov/pubmed/15950434 DMYTC4I DI DMYTC4I DMYTC4I DN NeuVax DMYTC4I MI TT6EO5L DMYTC4I MN Erbb2 tyrosine kinase receptor (HER2) DMYTC4I MT DTT DMYTC4I RN The HER2 peptide nelipepimut-S (E75) vaccine (NeuVax in breast cancer patients at risk for recurrence: correlation of immunologic data with clinical response. Immunotherapy. 2014;6(5):519-31. DMYTC4I RU https://pubmed.ncbi.nlm.nih.gov/24896623 DMJ2KIE DI DMJ2KIE DMJ2KIE DN NI-101 DMJ2KIE MI TTE4KHA DMJ2KIE MN Amyloid beta A4 protein (APP) DMJ2KIE MT DTT DMJ2KIE RN Disease-modifying drugs in Alzheimer's disease. Drug Des Devel Ther. 2013; 7: 1471-1479. DMJ2KIE RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3862506/ DMFBNA3 DI DMFBNA3 DMFBNA3 DN Nicaraven DMFBNA3 MI TTVDSZ0 DMFBNA3 MN Poly [ADP-ribose] polymerase 1 (PARP1) DMFBNA3 MT DTT DMFBNA3 MA Modulator DMFBNA3 RN Inhibition of poly (ADP-ribose) polymerase as a protective effect of nicaraven in ionizing radiation- and ara-C-induced cell death. Anticancer Res. 2006 Sep-Oct;26(5A):3421-7. DMFBNA3 RU https://pubmed.ncbi.nlm.nih.gov/17094462 DM376WT DI DM376WT DM376WT DN NKTR 214 DM376WT MI TT9721Y DM376WT MN Interleukin 2 receptor beta (IL2RB) DM376WT MT DTT DM376WT MA Agonist DM376WT RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DM376WT RU http://phrma-docs.phrma.org/files/dmfile/MID_Immuno-Oncology-2017_Drug-List1.pdf DM45DS8 DI DM45DS8 DM45DS8 DN NKTR-181 DM45DS8 MI TTKWM86 DM45DS8 MN Opioid receptor mu (MOP) DM45DS8 MT DTT DM45DS8 MA Agonist DM45DS8 RN A Review of Abuse-Deterrent Opioids For Chronic Nonmalignant Pain. P T. 2012 July; 37(7): 412-418. DM45DS8 RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3411218/ DMACYW6 DI DMACYW6 DMACYW6 DN NKTR-214 DMACYW6 MI TT9721Y DMACYW6 MN Interleukin 2 receptor beta (IL2RB) DMACYW6 MT DTT DMACYW6 MA Agonist DMACYW6 RN Bempegaldesleukin selectively depletes intratumoral Tregs and potentiates T cell-mediated cancer therapy. Nat Commun. 2020 Jan 31;11(1):661. DMACYW6 RU https://pubmed.ncbi.nlm.nih.gov/32005826 DMDJLY9 DI DMDJLY9 DMDJLY9 DN NM-702 DMDJLY9 MI TTUST1O DMDJLY9 MN Phosphodiesterase (PDE) DMDJLY9 MT DTT DMDJLY9 MA Inhibitor DMDJLY9 RN The novel phosphodiesterase inhibitor NM-702 improves claudication-limited exercise performance in patients with peripheral arterial disease. J Am Coll Cardiol. 2006 Dec 19;48(12):2539-45. DMDJLY9 RU https://pubmed.ncbi.nlm.nih.gov/17174195 DMDJLY9 DI DMDJLY9 DMDJLY9 DN NM-702 DMDJLY9 MI TTKNWZ4 DMDJLY9 MN Thromboxane-A synthase (TBXAS1) DMDJLY9 MT DTT DMDJLY9 MA Inhibitor DMDJLY9 RN The novel phosphodiesterase inhibitor NM-702 improves claudication-limited exercise performance in patients with peripheral arterial disease. J Am Coll Cardiol. 2006 Dec 19;48(12):2539-45. DMDJLY9 RU https://pubmed.ncbi.nlm.nih.gov/17174195 DMDGK83 DI DMDGK83 DMDGK83 DN NN1841 DMDGK83 MI TTAXGIP DMDGK83 MN Coagulation factor XIII (F13B) DMDGK83 MT DTT DMDGK83 MA Modulator DMDGK83 RN Catridecacog: a breakthrough in the treatment of congenital factor XIII A-subunit deficiency. J Blood Med. 2014 Jul 9;5:107-13. DMDGK83 RU https://pubmed.ncbi.nlm.nih.gov/25031548 DM0QV27 DI DM0QV27 DM0QV27 DN NN5401 DM0QV27 MI TTCBFJO DM0QV27 MN Insulin receptor (INSR) DM0QV27 MT DTT DM0QV27 MA Modulator DM0QV27 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1800). DM0QV27 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1800 DM1PI9G DI DM1PI9G DM1PI9G DN NN8717 DM1PI9G MI TTAXGIP DM1PI9G MN Coagulation factor XIII (F13B) DM1PI9G MT DTT DM1PI9G MA Modulator DM1PI9G RN Topical recombinant thrombin at a concentration of 1000 IU/mL reliably shortens in vivo TTH and delivers durable hemostasis in the presence of heparin anticoagulation and clopidogrel platelet inhibition in a rabbit model of vascular bleeding. Ann Surg Innov Res. 2009; 3: 14. DM1PI9G RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2786906/ DMOF0CA DI DMOF0CA DMOF0CA DN Nolatrexed DMOF0CA MI DTI7UX6 DMOF0CA MN Breast cancer resistance protein (ABCG2) DMOF0CA MT DTP DMOF0CA MA Substrate DMOF0CA RN Mutant Gly482 and Thr482 ABCG2 mediate high-level resistance to lipophilic antifolates. Cancer Chemother Pharmacol. 2006 Dec;58(6):826-34. DMOF0CA RU https://doi.org/10.1007/s00280-006-0230-9 DMOF0CA DI DMOF0CA DMOF0CA DN Nolatrexed DMOF0CA MI TTU6BFZ DMOF0CA MN Candida Thymidylate synthase (Candi TMP1) DMOF0CA MT DTT DMOF0CA MA Inhibitor DMOF0CA RN A phase I study of the lipophilic thymidylate synthase inhibitor Thymitaq (nolatrexed dihydrochloride) given by 10-day oral administration. Br J Cancer. 1999 Feb;79(5-6):915-20. DMOF0CA RU https://pubmed.ncbi.nlm.nih.gov/10070890 DMMC3Y8 DI DMMC3Y8 DMMC3Y8 DN NPC-01 DMMC3Y8 MI TTZAYWL DMMC3Y8 MN Estrogen receptor (ESR) DMMC3Y8 MT DTT DMMC3Y8 MA Modulator DMMC3Y8 RN ClinicalTrials.gov (NCT01246791) Pharmacokinetics of NPC-01 After Single Oral Administration in Healthy Female Volunteers. U.S. National Institutes of Health. DMMC3Y8 RU https://clinicaltrials.gov/ct2/show/NCT01246791 DMMC3Y8 DI DMMC3Y8 DMMC3Y8 DN NPC-01 DMMC3Y8 MI TTUV8G9 DMMC3Y8 MN Progesterone receptor (PGR) DMMC3Y8 MT DTT DMMC3Y8 MA Agonist DMMC3Y8 RN ClinicalTrials.gov (NCT01246791) Pharmacokinetics of NPC-01 After Single Oral Administration in Healthy Female Volunteers. U.S. National Institutes of Health. DMMC3Y8 RU https://clinicaltrials.gov/ct2/show/NCT01246791 DMCMIJ1 DI DMCMIJ1 DMCMIJ1 DN NT0202 DMCMIJ1 MI TTIU98M DMCMIJ1 MN Trace amine-associated receptor-1 (TAAR1) DMCMIJ1 MT DTT DMCMIJ1 MA Agonist DMCMIJ1 RN Methamphetamine and HIV-1-induced neurotoxicity: role of trace amine associated receptor 1 cAMP signaling in astrocytes. Neuropharmacology. 2014 Oct;85:499-507. DMCMIJ1 RU https://pubmed.ncbi.nlm.nih.gov/24950453 DMA16IL DI DMA16IL DMA16IL DN NU-100 DMA16IL MI TT4TZ8J DMA16IL MN Interferon-beta (IFNB1) DMA16IL MT DTT DMA16IL MA Modulator DMA16IL RN PEGylated interferon beta-1a in the treatment of multiple sclerosis - an update. Biologics. 2013; 7: 131-138. DMA16IL RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3686537/ DM8JWNA DI DM8JWNA DM8JWNA DN NVP-LAQ824 DM8JWNA MI TTBH0VX DM8JWNA MN Histone deacetylase (HDAC) DM8JWNA MT DTT DM8JWNA MA Inhibitor DM8JWNA RN Emerging therapies for multiple myeloma. Expert Opin Emerg Drugs. 2009 Mar;14(1):99-127. DM8JWNA RU https://pubmed.ncbi.nlm.nih.gov/19249983 DM8JWNA DI DM8JWNA DM8JWNA DN NVP-LAQ824 DM8JWNA MI TT6R7JZ DM8JWNA MN Histone deacetylase 1 (HDAC1) DM8JWNA MT DTT DM8JWNA MA Inhibitor DM8JWNA RN NVP-LAQ824 is a potent novel histone deacetylase inhibitor with significant activity against multiple myeloma. Blood. 2003 Oct 1;102(7):2615-22. DM8JWNA RU https://pubmed.ncbi.nlm.nih.gov/12816865 DM3L2GT DI DM3L2GT DM3L2GT DN O6-Benzylguanine alkylade DM3L2GT MI TTJ8DV7 DM3L2GT MN O-6-methylguanine-DNA-alkyltransferase (MGMT) DM3L2GT MT DTT DM3L2GT MA Modulator DM3L2GT RN Phase II trial of temozolomide plus o6-benzylguanine in adults with recurrent, temozolomide-resistant malignant glioma. J Clin Oncol. 2009 Mar 10;27(8):1262-7. DM3L2GT RU https://pubmed.ncbi.nlm.nih.gov/19204199 DMENDP6 DI DMENDP6 DMENDP6 DN OBI-1 DMENDP6 MI TT1290U DMENDP6 MN Coagulation factor VIII (F8) DMENDP6 MT DTT DMENDP6 MA Modulator DMENDP6 RN Efficacy and safety of OBI-1, an antihaemophilic factor VIII (recombinant), porcine sequence, in subjects with acquired haemophilia A. Haemophilia. 2015 Mar;21(2):162-70. DMENDP6 RU https://pubmed.ncbi.nlm.nih.gov/25623166 DM7KI4E DI DM7KI4E DM7KI4E DN Oblimersen DM7KI4E MI TTJGNVC DM7KI4E MN Apoptosis regulator Bcl-2 (BCL-2) DM7KI4E MT DTT DM7KI4E MA Inhibitor DM7KI4E RN Emerging therapies for multiple myeloma. Expert Opin Emerg Drugs. 2009 Mar;14(1):99-127. DM7KI4E RU https://pubmed.ncbi.nlm.nih.gov/19249983 DMEDSVJ DI DMEDSVJ DMEDSVJ DN Ociperlimab DMEDSVJ MI TTWNL74 DMEDSVJ MN V-set and immunoglobulin domain-containing protein 9 (TIGIT) DMEDSVJ MT DTT DMEDSVJ MA Inhibitor DMEDSVJ RN Clinical pipeline report, company report or official report of BeiGene. DMEDSVJ RU https://www.beigene.com/science-and-product-portfolio/pipeline/ociperlimab DM1EO3G DI DM1EO3G DM1EO3G DN Odanacatib DM1EO3G MI TTDZN01 DM1EO3G MN Cathepsin K (CTSK) DM1EO3G MT DTT DM1EO3G MA Inhibitor DM1EO3G RN A novel c-Met inhibitor, MK8033, synergizes with carboplatin plus paclitaxel to inhibit ovarian cancer cell growth. Oncol Rep. 2013 May;29(5):2011-8. DM1EO3G RU https://pubmed.ncbi.nlm.nih.gov/23467907 DM1EO3G DI DM1EO3G DM1EO3G DN Odanacatib DM1EO3G MI DES5XRU DM1EO3G MN Cytochrome P450 2C8 (CYP2C8) DM1EO3G MT DME DM1EO3G MA Metabolism DM1EO3G RN Disposition and metabolism of the cathepsin K inhibitor odanacatib in humans. Drug Metab Dispos. 2014 May;42(5):818-27. DM1EO3G RU https://www.ncbi.nlm.nih.gov/pubmed/?term=24553380 DM1EO3G DI DM1EO3G DM1EO3G DN Odanacatib DM1EO3G MI DE4LYSA DM1EO3G MN Cytochrome P450 3A4 (CYP3A4) DM1EO3G MT DME DM1EO3G MA Metabolism DM1EO3G RN Disposition and metabolism of the cathepsin K inhibitor odanacatib in humans. Drug Metab Dispos. 2014 May;42(5):818-27. DM1EO3G RU https://www.ncbi.nlm.nih.gov/pubmed/?term=24553380 DMYN391 DI DMYN391 DMYN391 DN Odevixibat DMYN391 MI TTPI1M5 DMYN391 MN Ileal sodium/bile acid cotransporter (SLC10A2) DMYN391 MT DTT DMYN391 MA Inhibitor DMYN391 RN Ileal bile acid transporter inhibition as an anticholestatic therapeutic target in biliary atresia and other cholestatic disorders. Hepatol Int. 2020 Sep;14(5):677-689. DMYN391 RU https://pubmed.ncbi.nlm.nih.gov/32653991 DMBWO5T DI DMBWO5T DMBWO5T DN ODT-8 DMBWO5T MI TTIND6G DMBWO5T MN Somatostatin receptor type 1 (SSTR1) DMBWO5T MT DTT DMBWO5T MA Inhibitor DMBWO5T RN Somatostatin receptor 1 selective analogues: 3. Dicyclic peptides. J Med Chem. 2005 Jan 27;48(2):515-22. DMBWO5T RU https://pubmed.ncbi.nlm.nih.gov/15658865 DMBWO5T DI DMBWO5T DMBWO5T DN ODT-8 DMBWO5T MI TTZ6T9E DMBWO5T MN Somatostatin receptor type 2 (SSTR2) DMBWO5T MT DTT DMBWO5T MA Inhibitor DMBWO5T RN Somatostatin receptor 1 selective analogues: 3. Dicyclic peptides. J Med Chem. 2005 Jan 27;48(2):515-22. DMBWO5T RU https://pubmed.ncbi.nlm.nih.gov/15658865 DMBWO5T DI DMBWO5T DMBWO5T DN ODT-8 DMBWO5T MI TTJX3UE DMBWO5T MN Somatostatin receptor type 3 (SSTR3) DMBWO5T MT DTT DMBWO5T MA Inhibitor DMBWO5T RN Somatostatin receptor 1 selective analogues: 3. Dicyclic peptides. J Med Chem. 2005 Jan 27;48(2):515-22. DMBWO5T RU https://pubmed.ncbi.nlm.nih.gov/15658865 DMBWO5T DI DMBWO5T DMBWO5T DN ODT-8 DMBWO5T MI TTAE1BR DMBWO5T MN Somatostatin receptor type 4 (SSTR4) DMBWO5T MT DTT DMBWO5T MA Inhibitor DMBWO5T RN Somatostatin receptor 1 selective analogues: 3. Dicyclic peptides. J Med Chem. 2005 Jan 27;48(2):515-22. DMBWO5T RU https://pubmed.ncbi.nlm.nih.gov/15658865 DMBWO5T DI DMBWO5T DMBWO5T DN ODT-8 DMBWO5T MI TT2BC4G DMBWO5T MN Somatostatin receptor type 5 (SSTR5) DMBWO5T MT DTT DMBWO5T MA Inhibitor DMBWO5T RN Somatostatin receptor 1 selective analogues: 3. Dicyclic peptides. J Med Chem. 2005 Jan 27;48(2):515-22. DMBWO5T RU https://pubmed.ncbi.nlm.nih.gov/15658865 DM1FBZ7 DI DM1FBZ7 DM1FBZ7 DN Olodaterol/tiotropium bromide DM1FBZ7 MI DECB0K3 DM1FBZ7 MN Cytochrome P450 2D6 (CYP2D6) DM1FBZ7 MT DME DM1FBZ7 MA Metabolism DM1FBZ7 RN Tiotropium rromide/olodaterol (Stiolto Respimat): once-daily combination therapy for the maintenance of COPD. P T. 2016 Feb;41(2):97-102. DM1FBZ7 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=26908999 DM1FBZ7 DI DM1FBZ7 DM1FBZ7 DN Olodaterol/tiotropium bromide DM1FBZ7 MI DE4LYSA DM1FBZ7 MN Cytochrome P450 3A4 (CYP3A4) DM1FBZ7 MT DME DM1FBZ7 MA Metabolism DM1FBZ7 RN Tiotropium bromide. A review of its use as maintenance therapy in patients with COPD. Treat Respir Med. 2004;3(4):247-68. DM1FBZ7 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=15350163 DM4Z9QI DI DM4Z9QI DM4Z9QI DN Olokizumab DM4Z9QI MI TTT1V78 DM4Z9QI MN Interleukin-6 (IL6) DM4Z9QI MT DTT DM4Z9QI MA Modulator DM4Z9QI RN Efficacy and safety of olokizumab in patients with rheumatoid arthritis with an inadequate response to TNF inhibitor therapy: outcomes of a randomised Phase IIb study. Ann Rheum Dis. 2014 September; 73(9): 1607-1615. DM4Z9QI RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4145439/ DM624TW DI DM624TW DM624TW DN Omecamtiv mecarbil DM624TW MI TT9WOBN DM624TW MN Cardiac myosin (MYBPC3) DM624TW MT DTT DM624TW MA Modulator DM624TW RN CK-1827452, a sarcomere-directed cardiac myosin activator for acute and chronic heart disease. IDrugs. 2009 Apr;12(4):243-51. DM624TW RU https://pubmed.ncbi.nlm.nih.gov/19350469 DMBWY8V DI DMBWY8V DMBWY8V DN Omega-6-FA DMBWY8V MI DE87OZS DMBWY8V MN Arachidonate 5-lipoxygenase (ALOX5) DMBWY8V MT DME DMBWY8V MA Metabolism DMBWY8V RN Health implications of high dietary omega-6 polyunsaturated Fatty acids. J Nutr Metab. 2012;2012:539426. DMBWY8V RU https://www.ncbi.nlm.nih.gov/pubmed/?term=22570770 DMBWY8V DI DMBWY8V DMBWY8V DN Omega-6-FA DMBWY8V MI DE05S8C DMBWY8V MN Fatty acid desaturase 1 (FADS1) DMBWY8V MT DME DMBWY8V MA Metabolism DMBWY8V RN Health implications of high dietary omega-6 polyunsaturated Fatty acids. J Nutr Metab. 2012;2012:539426. DMBWY8V RU https://www.ncbi.nlm.nih.gov/pubmed/?term=22570770 DMBWY8V DI DMBWY8V DMBWY8V DN Omega-6-FA DMBWY8V MI DEDI4B8 DMBWY8V MN Fatty acid desaturase 2 (FADS2) DMBWY8V MT DME DMBWY8V MA Metabolism DMBWY8V RN Health implications of high dietary omega-6 polyunsaturated Fatty acids. J Nutr Metab. 2012;2012:539426. DMBWY8V RU https://www.ncbi.nlm.nih.gov/pubmed/?term=22570770 DMBWY8V DI DMBWY8V DMBWY8V DN Omega-6-FA DMBWY8V MI DE492CE DMBWY8V MN Prostaglandin G/H synthase 2 (COX-2) DMBWY8V MT DME DMBWY8V MA Metabolism DMBWY8V RN Health implications of high dietary omega-6 polyunsaturated Fatty acids. J Nutr Metab. 2012;2012:539426. DMBWY8V RU https://www.ncbi.nlm.nih.gov/pubmed/?term=22570770 DMK6QBZ DI DMK6QBZ DMK6QBZ DN OMS721 DMK6QBZ MI TTR01E9 DMK6QBZ MN Mannan-binding lectin serine protease-2 (MASP2) DMK6QBZ MT DTT DMK6QBZ MA Inhibitor DMK6QBZ RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMK6QBZ RU http://phrma-docs.phrma.org/files/dmfile/medicines-in-development-drug-list-autoimmune-diseases.pdf DMU86DM DI DMU86DM DMU86DM DN ONO-1101 DMU86DM MI DECB0K3 DMU86DM MN Cytochrome P450 2D6 (CYP2D6) DMU86DM MT DME DMU86DM MA Metabolism DMU86DM RN Application of substrate depletion assay to evaluation of CYP isoforms responsible for stereoselective metabolism of carvedilol. Drug Metab Pharmacokinet. 2016 Dec;31(6):425-432. DMU86DM RU https://www.ncbi.nlm.nih.gov/pubmed/?term=27836712 DM06KRC DI DM06KRC DM06KRC DN Oregovomab DM06KRC MI TTC1PS3 DM06KRC MN Ovarian carcinoma antigen CA125 (MUC16) DM06KRC MT DTT DM06KRC RN MUC16 (CA125): tumor biomarker to cancer therapy, a work in progress. Mol Cancer. 2014; 13: 129. DM06KRC RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4046138/ DMWD3IV DI DMWD3IV DMWD3IV DN Oseltamivir + hydroxychloroquine DMWD3IV MI TTZGK1R DMWD3IV MN HUMAN glycosylation of host receptor (GHR) DMWD3IV MT DTT DMWD3IV MA Inhibitor DMWD3IV RN Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro. Cell Res. 2020 Mar;30(3):269-271. DMWD3IV RU https://pubmed.ncbi.nlm.nih.gov/32020029 DMWD3IV DI DMWD3IV DMWD3IV DN Oseltamivir + hydroxychloroquine DMWD3IV MI TTD16BI DMWD3IV MN HUMAN pH-dependent viral fusion/replication (pH-DVF/R) DMWD3IV MT DTT DMWD3IV MA Inhibitor DMWD3IV RN Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro. Cell Res. 2020 Mar;30(3):269-271. DMWD3IV RU https://pubmed.ncbi.nlm.nih.gov/32020029 DMWD3IV DI DMWD3IV DMWD3IV DN Oseltamivir + hydroxychloroquine DMWD3IV MI TT3A1EZ DMWD3IV MN HUMAN toll-like receptor 7/9 signalling pathway (TLR7/9 pathway) DMWD3IV MT DTT DMWD3IV MA Inhibitor DMWD3IV RN Mechanisms of action of hydroxychloroquine and chloroquine: implications for rheumatology. Nat Rev Rheumatol. 2020 Mar;16(3):155-166. DMWD3IV RU https://pubmed.ncbi.nlm.nih.gov/32034323 DMHKZLF DI DMHKZLF DMHKZLF DN OSI-906 DMHKZLF MI TTHRID2 DMHKZLF MN Insulin-like growth factor I receptor (IGF1R) DMHKZLF MT DTT DMHKZLF MA Inhibitor DMHKZLF RN Imidazo[2,1-b]thiazoles: multitargeted inhibitors of both the insulin-like growth factor receptor and members of the epidermal growth factor family... Bioorg Med Chem Lett. 2010 Apr 15;20(8):2452-5. DMHKZLF RU https://pubmed.ncbi.nlm.nih.gov/20346655 DM7R145 DI DM7R145 DM7R145 DN Otesaconazole DM7R145 MI TTTSOUD DM7R145 MN Candida Cytochrome P450 51 (Candi ERG11) DM7R145 MT DTT DM7R145 MA Inhibitor DM7R145 RN Efficacy of the clinical agent VT-1161 against fluconazole-sensitive and -resistant Candida albicans in a murine model of vaginal candidiasis. Antimicrob Agents Chemother. 2015 Sep;59(9):5567-73. DM7R145 RU https://pubmed.ncbi.nlm.nih.gov/26124165 DMLMS6J DI DMLMS6J DMLMS6J DN OTL-101 DMLMS6J MI TTLP57V DMLMS6J MN Adenosine deaminase (ADA) DMLMS6J MT DTT DMLMS6J MA Replacement DMLMS6J RN Clinical pipeline report, company report or official report of Orchard Therapeutics. DMLMS6J RU https://www.orchard-tx.com/approach/pipeline/ DM3BK2Y DI DM3BK2Y DM3BK2Y DN OTL-103 DM3BK2Y MI TTE8T73 DM3BK2Y MN Wiskott-Aldrich syndrome protein (WAS) DM3BK2Y MT DTT DM3BK2Y MA Replacement DM3BK2Y RN Clinical pipeline report, company report or official report of Orchard Therapeutics. DM3BK2Y RU https://www.orchard-tx.com/approach/pipeline/ DM5DRMY DI DM5DRMY DM5DRMY DN P1101 DM5DRMY MI TT95SOA DM5DRMY MN Interferon alpha (IFNA) DM5DRMY MT DTT DM5DRMY MA Inhibitor DM5DRMY RN Molecular responses and chromosomal aberrations in patients with polycythemia vera treated with peg-proline-interferon alpha-2b. Am J Hematol. 2015 Apr;90(4):288-94. DM5DRMY RU https://pubmed.ncbi.nlm.nih.gov/25545244 DM7WYXJ DI DM7WYXJ DM7WYXJ DN P-1101 DM7WYXJ MI TTSIUJ9 DM7WYXJ MN Interferon-alpha 2 (IFNA2) DM7WYXJ MT DTT DM7WYXJ MA Modulator DM7WYXJ RN Effects of PEG-interferon-alpha-2A on Schistosoma mansoni infection in mice. J Parasitol. 2010 Aug;96(4):703-8. DM7WYXJ RU https://pubmed.ncbi.nlm.nih.gov/20486736 DM9PVHX DI DM9PVHX DM9PVHX DN P2B-001 DM9PVHX MI TTEX248 DM9PVHX MN Dopamine D2 receptor (D2R) DM9PVHX MT DTT DM9PVHX MA Inhibitor DM9PVHX RN Pharmacology of pramipexole, a dopamine D3-preferring agonist useful in treating Parkinson's disease. Clin Neuropharmacol. 1998 May-Jun;21(3):141-51. DM9PVHX RU https://pubmed.ncbi.nlm.nih.gov/9617505 DM9PVHX DI DM9PVHX DM9PVHX DN P2B-001 DM9PVHX MI TT4C8EA DM9PVHX MN Dopamine D3 receptor (D3R) DM9PVHX MT DTT DM9PVHX MA Inhibitor DM9PVHX RN Pharmacology of pramipexole, a dopamine D3-preferring agonist useful in treating Parkinson's disease. Clin Neuropharmacol. 1998 May-Jun;21(3):141-51. DM9PVHX RU https://pubmed.ncbi.nlm.nih.gov/9617505 DM9PVHX DI DM9PVHX DM9PVHX DN P2B-001 DM9PVHX MI TTGP7BY DM9PVHX MN Monoamine oxidase type B (MAO-B) DM9PVHX MT DTT DM9PVHX MA Inhibitor DM9PVHX RN Rasagiline (TVP-1012): a new selective monoamine oxidase inhibitor for Parkinson's disease. Am J Geriatr Pharmacother. 2006 Dec;4(4):330-46. DM9PVHX RU https://pubmed.ncbi.nlm.nih.gov/17296539 DM1T6ZN DI DM1T6ZN DM1T6ZN DN Pacritinib DM1T6ZN MI TTGJCWZ DM1T6ZN MN Fms-like tyrosine kinase 3 (FLT-3) DM1T6ZN MT DTT DM1T6ZN MA Modulator DM1T6ZN RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1807). DM1T6ZN RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1807 DM1T6ZN DI DM1T6ZN DM1T6ZN DN Pacritinib DM1T6ZN MI TTRMX3V DM1T6ZN MN Janus kinase 2 (JAK-2) DM1T6ZN MT DTT DM1T6ZN MA Modulator DM1T6ZN RN National Cancer Institute Drug Dictionary (drug id 609888). DM1T6ZN RU http://www.cancer.gov/publications/dictionaries/cancer-drug?cdrid=609888 DMFKOR9 DI DMFKOR9 DMFKOR9 DN Pafuramidine DMFKOR9 MI DE3GT9C DMFKOR9 MN Cytochrome P450 4F2 (CYP4F2) DMFKOR9 MT DME DMFKOR9 MA Metabolism DMFKOR9 RN Human enteric microsomal CYP4F enzymes O-demethylate the antiparasitic prodrug pafuramidine. Drug Metab Dispos. 2007 Nov;35(11):2067-75. DMFKOR9 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=17709372 DMFKOR9 DI DMFKOR9 DMFKOR9 DN Pafuramidine DMFKOR9 MI TTUTN1I DMFKOR9 MN Human Deoxyribonucleic acid (hDNA) DMFKOR9 MT DTT DMFKOR9 MA Modulator DMFKOR9 RN DNA Minor Groove Induced Dimerization of Heterocyclic Cations: Compound Structure, Binding Affinity and Specificity for a TTAA Site DMFKOR9 RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2988403 DMAD2OZ DI DMAD2OZ DMAD2OZ DN Palovarotene DMAD2OZ MI TT1Q3IE DMAD2OZ MN Retinoic acid receptor gamma (RARG) DMAD2OZ MT DTT DMAD2OZ MA Agonist DMAD2OZ RN Randomised controlled trial for emphysema with a selective agonist of the gamma-type retinoic acid receptor. Eur Respir J. 2012 Aug;40(2):306-12. DMAD2OZ RU https://pubmed.ncbi.nlm.nih.gov/22282548 DM4SKYI DI DM4SKYI DM4SKYI DN PAMAQUESIDE DM4SKYI MI TT61VTP DM4SKYI MN Cholesterol uptake (Chole uptake) DM4SKYI MT DTT DM4SKYI MA Modulator DM4SKYI RN Comparison of synthetic saponin cholesterol absorption inhibitors in rabbits: evidence for a non-stoichiometric, intestinal mechanism of action. J Lipid Res. 1999 Mar;40(3):464-74. DM4SKYI RU https://pubmed.ncbi.nlm.nih.gov/10064735 DMIRYU9 DI DMIRYU9 DMIRYU9 DN Pancopride DMIRYU9 MI TTNXLKE DMIRYU9 MN 5-HT 3 receptor (5HT3R) DMIRYU9 MT DTT DMIRYU9 MA Inhibitor DMIRYU9 RN Pancopride, a potent and long-acting 5-HT3 receptor antagonist, is orally effective against anticancer drug-evoked emesis. Eur J Pharmacol. 1992 Nov 10;222(2-3):257-64. DMIRYU9 RU https://pubmed.ncbi.nlm.nih.gov/1451737 DMEW5Z8 DI DMEW5Z8 DMEW5Z8 DN PARABEN DMEW5Z8 MI TTUNARX DMEW5Z8 MN Carbonic anhydrase (CA) DMEW5Z8 MT DTT DMEW5Z8 MA Inhibitor DMEW5Z8 RN Carbonic anhydrase inhibitors. Inhibition of mammalian isoforms I-XIV with a series of natural product polyphenols and phenolic acids. Bioorg Med Chem. 2010 Mar 15;18(6):2159-2164. DMEW5Z8 RU https://pubmed.ncbi.nlm.nih.gov/20185318 DMEW5Z8 DI DMEW5Z8 DMEW5Z8 DN PARABEN DMEW5Z8 MI TTHQPL7 DMEW5Z8 MN Carbonic anhydrase I (CA-I) DMEW5Z8 MT DTT DMEW5Z8 MA Inhibitor DMEW5Z8 RN Carbonic anhydrase inhibitors. Inhibition of mammalian isoforms I-XIV with a series of natural product polyphenols and phenolic acids. Bioorg Med Chem. 2010 Mar 15;18(6):2159-2164. DMEW5Z8 RU https://pubmed.ncbi.nlm.nih.gov/20185318 DMEW5Z8 DI DMEW5Z8 DMEW5Z8 DN PARABEN DMEW5Z8 MI TTANPDJ DMEW5Z8 MN Carbonic anhydrase II (CA-II) DMEW5Z8 MT DTT DMEW5Z8 MA Inhibitor DMEW5Z8 RN Carbonic anhydrase inhibitors. Inhibition of mammalian isoforms I-XIV with a series of natural product polyphenols and phenolic acids. Bioorg Med Chem. 2010 Mar 15;18(6):2159-2164. DMEW5Z8 RU https://pubmed.ncbi.nlm.nih.gov/20185318 DMEW5Z8 DI DMEW5Z8 DMEW5Z8 DN PARABEN DMEW5Z8 MI TTZHA0O DMEW5Z8 MN Carbonic anhydrase IV (CA-IV) DMEW5Z8 MT DTT DMEW5Z8 MA Inhibitor DMEW5Z8 RN Carbonic anhydrase inhibitors. Inhibition of mammalian isoforms I-XIV with a series of natural product polyphenols and phenolic acids. Bioorg Med Chem. 2010 Mar 15;18(6):2159-2164. DMEW5Z8 RU https://pubmed.ncbi.nlm.nih.gov/20185318 DMEW5Z8 DI DMEW5Z8 DMEW5Z8 DN PARABEN DMEW5Z8 MI TT2LVK8 DMEW5Z8 MN Carbonic anhydrase IX (CA-IX) DMEW5Z8 MT DTT DMEW5Z8 MA Inhibitor DMEW5Z8 RN Carbonic anhydrase inhibitors. Inhibition of mammalian isoforms I-XIV with a series of natural product polyphenols and phenolic acids. Bioorg Med Chem. 2010 Mar 15;18(6):2159-2164. DMEW5Z8 RU https://pubmed.ncbi.nlm.nih.gov/20185318 DMEW5Z8 DI DMEW5Z8 DMEW5Z8 DN PARABEN DMEW5Z8 MI TTCFSPE DMEW5Z8 MN Carbonic anhydrase VI (CA-VI) DMEW5Z8 MT DTT DMEW5Z8 MA Inhibitor DMEW5Z8 RN Carbonic anhydrase inhibitors. Inhibition of mammalian isoforms I-XIV with a series of natural product polyphenols and phenolic acids. Bioorg Med Chem. 2010 Mar 15;18(6):2159-2164. DMEW5Z8 RU https://pubmed.ncbi.nlm.nih.gov/20185318 DMEW5Z8 DI DMEW5Z8 DMEW5Z8 DN PARABEN DMEW5Z8 MI TTSYM0R DMEW5Z8 MN Carbonic anhydrase XII (CA-XII) DMEW5Z8 MT DTT DMEW5Z8 MA Inhibitor DMEW5Z8 RN Carbonic anhydrase inhibitors. Inhibition of mammalian isoforms I-XIV with a series of natural product polyphenols and phenolic acids. Bioorg Med Chem. 2010 Mar 15;18(6):2159-2164. DMEW5Z8 RU https://pubmed.ncbi.nlm.nih.gov/20185318 DMEW5Z8 DI DMEW5Z8 DMEW5Z8 DN PARABEN DMEW5Z8 MI TTEYTKG DMEW5Z8 MN Carbonic anhydrase XIV (CA-XIV) DMEW5Z8 MT DTT DMEW5Z8 MA Inhibitor DMEW5Z8 RN Carbonic anhydrase inhibitors. Inhibition of mammalian isoforms I-XIV with a series of natural product polyphenols and phenolic acids. Bioorg Med Chem. 2010 Mar 15;18(6):2159-2164. DMEW5Z8 RU https://pubmed.ncbi.nlm.nih.gov/20185318 DM3H2U4 DI DM3H2U4 DM3H2U4 DN Patrome DM3H2U4 MI TTN451K DM3H2U4 MN Aromatic-L-amino-acid decarboxylase (DDC) DM3H2U4 MT DTT DM3H2U4 MA Modulator DM3H2U4 RN The aromatic-L-amino acid decarboxylase inhibitor carbidopa is selectively cytotoxic to human pulmonary carcinoid and small cell lung carcinoma cells. Clin Cancer Res. 2000 Nov;6(11):4365-72. DM3H2U4 RU https://pubmed.ncbi.nlm.nih.gov/11106255 DMHXTAQ DI DMHXTAQ DMHXTAQ DN Pazufloxacin DMHXTAQ MI TTN6J5F DMHXTAQ MN Bacterial DNA gyrase (Bact gyrase) DMHXTAQ MT DTT DMHXTAQ MA Inhibitor DMHXTAQ RN Target preference of 15 quinolones against Staphylococcus aureus, based on antibacterial activities and target inhibition. Antimicrob Agents Chemother. 2001 Dec;45(12):3544-7. DMHXTAQ RU https://www.ncbi.nlm.nih.gov/pubmed/11709337 DMHXTAQ DI DMHXTAQ DMHXTAQ DN Pazufloxacin DMHXTAQ MI TTFK8YB DMHXTAQ MN Bacterial DNA topoisomerase 4A (Bact parC) DMHXTAQ MT DTT DMHXTAQ MA Inhibitor DMHXTAQ RN Target preference of 15 quinolones against Staphylococcus aureus, based on antibacterial activities and target inhibition. Antimicrob Agents Chemother. 2001 Dec;45(12):3544-7. DMHXTAQ RU https://www.ncbi.nlm.nih.gov/pubmed/11709337 DMP3G0W DI DMP3G0W DMP3G0W DN Pazufloxacin DMP3G0W MI DTUGYRD DMP3G0W MN P-glycoprotein 1 (ABCB1) DMP3G0W MT DTP DMP3G0W MA Substrate DMP3G0W RN Possible involvement of P-glycoprotein in renal excretion of pazufloxacin in rats. Eur J Pharmacol. 2004 Oct 6;501(1-3):151-9. DMP3G0W RU https://doi.org/10.1016/j.ejphar.2004.08.013 DMJBHO0 DI DMJBHO0 DMJBHO0 DN PC-DAC:Insulin DMJBHO0 MI TTZOPHG DMJBHO0 MN Insulin (INS) DMJBHO0 MT DTT DMJBHO0 MA Modulator DMJBHO0 RN Development and Testing of Solid Dose Formulations Containing Polysialic Acid Insulin Conjugate: Next Generation of Long-Acting Insulin. J Diabetes Sci Technol. 2010 May; 4(3): 532-539. DMJBHO0 RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2901028/ DMMBC5W DI DMMBC5W DMMBC5W DN PDGF-BB DMMBC5W MI TTQA6SX DMMBC5W MN Platelet-derived growth factor B (PDGFB) DMMBC5W MT DTT DMMBC5W MA Modulator DMMBC5W RN Clinical pipeline report, company report or official report of Adocia. DMMBC5W RU http://www.adocia.fr/WP/products/bc-pdgf-bb-en/ DM53J6B DI DM53J6B DM53J6B DN PDR001 DM53J6B MI TTNBFWK DM53J6B MN Programmed cell death protein 1 (PD-1) DM53J6B MT DTT DM53J6B MA Antagonist DM53J6B RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DM53J6B RU http://phrma-docs.phrma.org/files/dmfile/MID_Skin_Diseases_2018_9_FINAL.pdf DMBKWAF DI DMBKWAF DMBKWAF DN Peg-G-CSF DMBKWAF MI TTC70AJ DMBKWAF MN Granulocyte colony-stimulating factor receptor (G-CSF-R) DMBKWAF MT DTT DMBKWAF MA Stimulator DMBKWAF RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1719). DMBKWAF RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1719 DMK6OFY DI DMK6OFY DMK6OFY DN Peginterferon lambda-1a DMK6OFY MI TTM624L DMK6OFY MN Interleukin-29 (IL29) DMK6OFY MT DTT DMK6OFY MA Agonist DMK6OFY RN Preclinical and clinical development of pegylated interferon-lambda 1 in chronic hepatitis C. J Interferon Cytokine Res. 2010 Aug;30(8):591-5. DMK6OFY RU https://pubmed.ncbi.nlm.nih.gov/20645873 DMESAZK DI DMESAZK DMESAZK DN Peretinoin DMESAZK MI TTOD7B3 DMESAZK MN Retinoic acid receptor (RAR) DMESAZK MT DTT DMESAZK MA Modulator DMESAZK RN Peretinoin, an acyclic retinoid, improves the hepatic gene signature of chronic hepatitis C following curative therapy of hepatocellular carcinoma. BMC Cancer. 2013 Apr 15;13:191. DMESAZK RU https://pubmed.ncbi.nlm.nih.gov/23587162 DMUP5Z0 DI DMUP5Z0 DMUP5Z0 DN PF-03084014 DMUP5Z0 MI TTE4KHA DMUP5Z0 MN Amyloid beta A4 protein (APP) DMUP5Z0 MT DTT DMUP5Z0 MA Inhibitor DMUP5Z0 RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMUP5Z0 RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DMUP5Z0 DI DMUP5Z0 DMUP5Z0 DN PF-03084014 DMUP5Z0 MI TT9W8GU DMUP5Z0 MN Gamma-secretase (GS) DMUP5Z0 MT DTT DMUP5Z0 MA Modulator DMUP5Z0 RN Pharmacodynamics and pharmacokinetics of the gamma-secretase inhibitor PF-3084014.J Pharmacol Exp Ther.2010 Jul;334(1):269-77. DMUP5Z0 RU https://www.ncbi.nlm.nih.gov/pubmed/20363853 DM0TWCY DI DM0TWCY DM0TWCY DN PF-04950615 DM0TWCY MI TTBRG7E DM0TWCY MN Proprotein convertase subtilisin/kexin type 9 (PCSK9) DM0TWCY MT DTT DM0TWCY RN Phase 3 data for PCSK9 inhibitor wows. Nat Biotechnol. 2013 Dec;31(12):1057-8. DM0TWCY RU https://pubmed.ncbi.nlm.nih.gov/24316621 DM8J29L DI DM8J29L DM8J29L DN PF-04965842 DM8J29L MI TTJSQEF DM8J29L MN Tyrosine-protein kinase (PTK) DM8J29L MT DTT DM8J29L MA Inhibitor DM8J29L RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DM8J29L RU http://phrma-docs.phrma.org/files/dmfile/MID_Skin_Diseases_2018_9_FINAL.pdf DM23BUP DI DM23BUP DM23BUP DN PF-05280014 DM23BUP MI TT6EO5L DM23BUP MN Erbb2 tyrosine kinase receptor (HER2) DM23BUP MT DTT DM23BUP MA Antagonist DM23BUP RN Comparative nonclinical assessments of the proposed biosimilar PF-05280014 and trastuzumab (Herceptin( )). BioDrugs. 2014 Oct;28(5):451-9. DM23BUP RU https://pubmed.ncbi.nlm.nih.gov/25001079 DMNZOCK DI DMNZOCK DMNZOCK DN PF-05280586 DMNZOCK MI TTUE541 DMNZOCK MN Leukocyte surface antigen Leu-16 (CD20) DMNZOCK MT DTT DMNZOCK MA Antagonist DMNZOCK RN Comparative nonclinical assessments of the proposed biosimilar PF-05280586 and rituximab (MabThera ). Toxicol Pathol. 2014 Oct;42(7):1069-81. DMNZOCK RU https://pubmed.ncbi.nlm.nih.gov/24604381 DM2GF14 DI DM2GF14 DM2GF14 DN PF-06410293 DM2GF14 MI TTF8CQI DM2GF14 MN Tumor necrosis factor (TNF) DM2GF14 MT DTT DM2GF14 RN Apoptosis and the FLIP and NF-kappa B proteins as pharmacodynamic criteria for biosimilar TNF-alpha antagonists. Biologics. 2014 Jul 31;8:211-20. DM2GF14 RU https://pubmed.ncbi.nlm.nih.gov/25114503 DMM4C95 DI DMM4C95 DMM4C95 DN PF-06438179 DMM4C95 MI TTF8CQI DMM4C95 MN Tumor necrosis factor (TNF) DMM4C95 MT DTT DMM4C95 MA Inhibitor DMM4C95 RN Biosimilars in the therapy of inflammatory bowel diseases. Eur J Gastroenterol Hepatol. 2014 Jun;26(6):581-7. DMM4C95 RU https://pubmed.ncbi.nlm.nih.gov/24722561 DMVHZDP DI DMVHZDP DMVHZDP DN PF-06439535 DMVHZDP MI TT9HKJA DMVHZDP MN Vascular endothelial growth factor (VEGF) DMVHZDP MT DTT DMVHZDP RN National Cancer Institute Drug Dictionary (drug id 43234). DMVHZDP RU http://www.cancer.gov/publications/dictionaries/cancer-drug?cdrid=43234 DMW63TQ DI DMW63TQ DMW63TQ DN PF-06741086 DMW63TQ MI TT068JH DMW63TQ MN Tissue factor pathway inhibitor (TFPI) DMW63TQ MT DTT DMW63TQ MA Inhibitor DMW63TQ RN Neutralizing Antibody Assay Development with High Drug and Target Tolerance to Support Clinical Development of an Anti-TFPI Therapeutic Monoclonal Antibody. AAPS J. 2019 Mar 29;21(3):46. DMW63TQ RU https://pubmed.ncbi.nlm.nih.gov/30927117 DMWPA4L DI DMWPA4L DMWPA4L DN PF-07055480 DMWPA4L MI TT1290U DMWPA4L MN Coagulation factor VIII (F8) DMWPA4L MT DTT DMWPA4L MA Replacement DMWPA4L RN Clinical pipeline report, company report or official report of Pfizer. DMWPA4L RU https://www.pfizer.com/science/rare-diseases/pipeline DMS1EQ7 DI DMS1EQ7 DMS1EQ7 DN PF-1228305 DMS1EQ7 MI TTKRD0G DMS1EQ7 MN Endothelin A receptor (EDNRA) DMS1EQ7 MT DTT DMS1EQ7 MA Antagonist DMS1EQ7 RN Pfizer. Product Development Pipeline. March 31 2009. DMS1EQ7 RU http://media.pfizer.com/files/research/pipeline/2009_0331/pipeline_2009_0331.pdf DMJ7IKW DI DMJ7IKW DMJ7IKW DN PF-4494700 DMJ7IKW MI TTMO9HF DMJ7IKW MN Advanced glycosylation end product receptor (AGER) DMJ7IKW MT DTT DMJ7IKW MA Antagonist DMJ7IKW RN Receptor for advanced glycation endproduct modulators: a new therapeutic target in Alzheimer's disease. Expert Opin Investig Drugs. 2015 Mar;24(3):393-9. DMJ7IKW RU https://pubmed.ncbi.nlm.nih.gov/25586103 DM5DAP3 DI DM5DAP3 DM5DAP3 DN PGF2ALPHA-IE DM5DAP3 MI TTT2ZAR DM5DAP3 MN Prostaglandin F2-alpha receptor (PTGFR) DM5DAP3 MT DTT DM5DAP3 MA Modulator DM5DAP3 RN Role of nitric oxide in PGF2 alpha-induced ocular hyperemia. Exp Eye Res. 1994 Oct;59(4):401-7. DM5DAP3 RU https://pubmed.ncbi.nlm.nih.gov/7532135 DM8Y12A DI DM8Y12A DM8Y12A DN PH-80 DM8Y12A MI TTOASGR DM8Y12A MN Neuroepithelial receptor (NR) DM8Y12A MT DTT DM8Y12A MA Modulator DM8Y12A RN Patents by Assignee Pherin Corporation. DM8Y12A RU http://patents.justia.com/assignee/pherin-corporation DMDC7OH DI DMDC7OH DMDC7OH DN PH94B NS DMDC7OH MI TTCI43M DMDC7OH MN GABA(A) receptor (GABAR) DMDC7OH MT DTT DMDC7OH MA Modulator DMDC7OH RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMDC7OH RU http://phrma-docs.phrma.org/files/dmfile/MID_Mental-Illness-2017-Drug-List_Final.pdf DMVEHM4 DI DMVEHM4 DMVEHM4 DN Phentermine+topiramate DMVEHM4 MI TTUNARX DMVEHM4 MN Carbonic anhydrase (CA) DMVEHM4 MT DTT DMVEHM4 MA Inhibitor DMVEHM4 RN Anti-obesity drugs. Expert Opin Pharmacother. 2008 Jun;9(8):1339-50. DMVEHM4 RU https://pubmed.ncbi.nlm.nih.gov/18473708 DMVEHM4 DI DMVEHM4 DMVEHM4 DN Phentermine+topiramate DMVEHM4 MI TTNJYV2 DMVEHM4 MN Gamma-aminobutyric acid receptor (GAR) DMVEHM4 MT DTT DMVEHM4 MA Modulator DMVEHM4 RN Anti-obesity drugs. Expert Opin Pharmacother. 2008 Jun;9(8):1339-50. DMVEHM4 RU https://pubmed.ncbi.nlm.nih.gov/18473708 DMGZPX6 DI DMGZPX6 DMGZPX6 DN PI-88 DMGZPX6 MI TTDCBX5 DMGZPX6 MN Vascular endothelial growth factor receptor 3 (FLT-4) DMGZPX6 MT DTT DMGZPX6 MA Modulator DMGZPX6 RN Company report (Medigen) DMGZPX6 RU http://www.medigen.com.tw/en/muparfostat-pi-88/ DM7OSHC DI DM7OSHC DM7OSHC DN Pinaverium bromide DM7OSHC MI TTXHYV6 DM7OSHC MN Voltage-gated L-type calcium channel (L-CaC) DM7OSHC MT DTT DM7OSHC MA Blocker DM7OSHC RN Emerging drugs for irritable bowel syndrome. Expert Opin Emerg Drugs. 2006 May;11(2):293-313. DM7OSHC RU https://pubmed.ncbi.nlm.nih.gov/16634703 DMRG1X3 DI DMRG1X3 DMRG1X3 DN Pirtobrutinib DMRG1X3 MI TTGM6VW DMRG1X3 MN Tyrosine-protein kinase BTK (ATK) DMRG1X3 MT DTT DMRG1X3 MA Inhibitor DMRG1X3 RN Targeting BTK in CLL: Beyond Ibrutinib. Curr Hematol Malig Rep. 2019 Jun;14(3):197-205. DMRG1X3 RU https://pubmed.ncbi.nlm.nih.gov/31028669 DMQGR45 DI DMQGR45 DMQGR45 DN Pixantrone DMQGR45 MI TT0IHXV DMQGR45 MN DNA topoisomerase II (TOP2) DMQGR45 MT DTT DMQGR45 MA Modulator DMQGR45 RN Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41. DMQGR45 RU https://www.ncbi.nlm.nih.gov/pubmed/15950434 DMCA6BW DI DMCA6BW DMCA6BW DN Pixykine DMCA6BW MI TT6MP2Z DMCA6BW MN GMCSFR-alpha (CSF2RA) DMCA6BW MT DTT DMCA6BW MA Modulator DMCA6BW RN Phase I/II trial of PIXY321 (granulocyte-macrophage colony stimulating factor/interleukin-3 fusion protein) for treatment of inherited and acquired... Br J Haematol. 1998 Nov;103(2):304-7. DMCA6BW RU https://www.ncbi.nlm.nih.gov/pubmed/9827896 DM1RWMY DI DM1RWMY DM1RWMY DN Plasma derived factor VIII PEGylated liposomal DM1RWMY MI TT1290U DM1RWMY MN Coagulation factor VIII (F8) DM1RWMY MT DTT DM1RWMY MA Modulator DM1RWMY RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2607). DM1RWMY RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2607 DMD7L48 DI DMD7L48 DMD7L48 DN Plinabulin DMD7L48 MI TTKIGZF DMD7L48 MN Guanine nucleotide exchange factor (GNEF) DMD7L48 MT DTT DMD7L48 MA Stimulator DMD7L48 RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMD7L48 RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DMD7L48 DI DMD7L48 DMD7L48 DN Plinabulin DMD7L48 MI TTYFKSZ DMD7L48 MN Tubulin beta (TUBB) DMD7L48 MT DTT DMD7L48 MA Modulator DMD7L48 RN NPI-2358 is a tubulin-depolymerizing agent: in-vitro evidence for activity as a tumor vascular-disrupting agent. Anticancer Drugs. 2006 Jan;17(1):25-31. DMD7L48 RU https://www.ncbi.nlm.nih.gov/pubmed/16317287 DMJ8AUE DI DMJ8AUE DMJ8AUE DN Plitidepsin DMJ8AUE MI DEJVYAZ DMJ8AUE MN Cytochrome P450 2A6 (CYP2A6) DMJ8AUE MT DME DMJ8AUE MA Metabolism DMJ8AUE RN In vitro characterization of the human biotransformation pathways of aplidine, a novel marine anti-cancer drug. Invest New Drugs. 2007 Feb;25(1):9-19. DMJ8AUE RU https://www.ncbi.nlm.nih.gov/pubmed/?term=16633717 DMJ8AUE DI DMJ8AUE DMJ8AUE DN Plitidepsin DMJ8AUE MI DEVDYN7 DMJ8AUE MN Cytochrome P450 2E1 (CYP2E1) DMJ8AUE MT DME DMJ8AUE MA Metabolism DMJ8AUE RN In vitro characterization of the human biotransformation pathways of aplidine, a novel marine anti-cancer drug. Invest New Drugs. 2007 Feb;25(1):9-19. DMJ8AUE RU https://www.ncbi.nlm.nih.gov/pubmed/?term=16633717 DMJ8AUE DI DMJ8AUE DMJ8AUE DN Plitidepsin DMJ8AUE MI DE4LYSA DMJ8AUE MN Cytochrome P450 3A4 (CYP3A4) DMJ8AUE MT DME DMJ8AUE MA Metabolism DMJ8AUE RN In vitro characterization of the human biotransformation pathways of aplidine, a novel marine anti-cancer drug. Invest New Drugs. 2007 Feb;25(1):9-19. DMJ8AUE RU https://www.ncbi.nlm.nih.gov/pubmed/?term=16633717 DMJ8AUE DI DMJ8AUE DMJ8AUE DN Plitidepsin DMJ8AUE MI TTSQC14 DMJ8AUE MN Palmitoyl-protein thioesterase 1 (PPT1) DMJ8AUE MT DTT DMJ8AUE MA Modulator DMJ8AUE RN Mode of action and pharmacogenomic biomarkers for exceptional responders to didemnin B DMJ8AUE RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4433765 DMV8EXG DI DMV8EXG DMV8EXG DN PolyHeme DMV8EXG MI TTQO71U DMV8EXG MN Hemoglobin (HB) DMV8EXG MT DTT DMV8EXG MA Modulator DMV8EXG RN Blood substitutes- the polyheme trials. Mcgill J Med. 2008 January; 11(1): 59-65. DMV8EXG RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2322929/ DMTD7AB DI DMTD7AB DMTD7AB DN Pracinostat DMTD7AB MI DEJGDUW DMTD7AB MN Cytochrome P450 1A2 (CYP1A2) DMTD7AB MT DME DMTD7AB MA Metabolism DMTD7AB RN Preclinical metabolism and disposition of SB939 (Pracinostat), an orally active histone deacetylase inhibitor, and prediction of human pharmacokinetics. Drug Metab Dispos. 2011 Dec;39(12):2219-32. DMTD7AB RU https://www.ncbi.nlm.nih.gov/pubmed/?term=21873472 DMTD7AB DI DMTD7AB DMTD7AB DN Pracinostat DMTD7AB MI DE4LYSA DMTD7AB MN Cytochrome P450 3A4 (CYP3A4) DMTD7AB MT DME DMTD7AB MA Metabolism DMTD7AB RN Preclinical metabolism and disposition of SB939 (Pracinostat), an orally active histone deacetylase inhibitor, and prediction of human pharmacokinetics. Drug Metab Dispos. 2011 Dec;39(12):2219-32. DMTD7AB RU https://www.ncbi.nlm.nih.gov/pubmed/?term=21873472 DMTD7AB DI DMTD7AB DMTD7AB DN Pracinostat DMTD7AB MI TTBH0VX DMTD7AB MN Histone deacetylase (HDAC) DMTD7AB MT DTT DMTD7AB MA Modulator DMTD7AB RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 8365). DMTD7AB RU http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=8365 DM2ZYX9 DI DM2ZYX9 DM2ZYX9 DN Pradaxa DM2ZYX9 MI DEB30C5 DM2ZYX9 MN Carboxylesterase 1 (CES1) DM2ZYX9 MT DME DM2ZYX9 MA Metabolism DM2ZYX9 RN Conventional liquid chromatography/triple quadrupole mass spectrometry based metabolite identification and semi-quantitative estimation approach in the investigation of in vitro dabigatran etexilate metabolism. Anal Bioanal Chem. 2013 Feb;405(5):1695-704. DM2ZYX9 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=23239178 DM2ZYX9 DI DM2ZYX9 DM2ZYX9 DN Pradaxa DM2ZYX9 MI DETHCPD DM2ZYX9 MN Carboxylesterase 2 (CES2) DM2ZYX9 MT DME DM2ZYX9 MA Metabolism DM2ZYX9 RN Conventional liquid chromatography/triple quadrupole mass spectrometry based metabolite identification and semi-quantitative estimation approach in the investigation of in vitro dabigatran etexilate metabolism. Anal Bioanal Chem. 2013 Feb;405(5):1695-704. DM2ZYX9 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=23239178 DMOMDXI DI DMOMDXI DMOMDXI DN Pratosartan DMOMDXI MI TT8DBY3 DMOMDXI MN Angiotensin II receptor type-1 (AGTR1) DMOMDXI MT DTT DMOMDXI MA Antagonist DMOMDXI RN Clinical efficacy of a new angiotensin II type 1 receptor blocker, pratosartan, in hypertensive patients. Hypertens Res. 2008 Feb;31(2):281-7. DMOMDXI RU https://pubmed.ncbi.nlm.nih.gov/18360048 DMLSOB7 DI DMLSOB7 DMLSOB7 DN Premarin/Pravachol DMLSOB7 MI TTZAYWL DMLSOB7 MN Estrogen receptor (ESR) DMLSOB7 MT DTT DMLSOB7 MA Modulator DMLSOB7 RN Lovastatin and beyond: the history of the HMG-CoA reductase inhibitors. Nat Rev Drug Discov. 2003 Jul;2(7):517-26. DMLSOB7 RU https://pubmed.ncbi.nlm.nih.gov/12815379 DMLSOB7 DI DMLSOB7 DMLSOB7 DN Premarin/Pravachol DMLSOB7 MI TTOM3J0 DMLSOB7 MN Estrogen receptor beta (ESR2) DMLSOB7 MT DTT DMLSOB7 MA Modulator DMLSOB7 RN Lovastatin and beyond: the history of the HMG-CoA reductase inhibitors. Nat Rev Drug Discov. 2003 Jul;2(7):517-26. DMLSOB7 RU https://pubmed.ncbi.nlm.nih.gov/12815379 DMLSOB7 DI DMLSOB7 DMLSOB7 DN Premarin/Pravachol DMLSOB7 MI TTPADOQ DMLSOB7 MN HMG-CoA reductase (HMGCR) DMLSOB7 MT DTT DMLSOB7 MA Modulator DMLSOB7 RN Lovastatin and beyond: the history of the HMG-CoA reductase inhibitors. Nat Rev Drug Discov. 2003 Jul;2(7):517-26. DMLSOB7 RU https://pubmed.ncbi.nlm.nih.gov/12815379 DMX9YLR DI DMX9YLR DMX9YLR DN Pridopidine DMX9YLR MI TTEX248 DMX9YLR MN Dopamine D2 receptor (D2R) DMX9YLR MT DTT DMX9YLR MA Modulator DMX9YLR RN Efficacy and safety of the dopaminergic stabilizer Pridopidine (ACR16) in patients with Huntington's disease. Clin Neuropharmacol. 2010 Sep-Oct;33(5):260-4. DMX9YLR RU https://pubmed.ncbi.nlm.nih.gov/20616707 DMD1FTP DI DMD1FTP DMD1FTP DN PRO-140 DMD1FTP MI TT2CEJG DMD1FTP MN C-C chemokine receptor type 5 (CCR5) DMD1FTP MT DTT DMD1FTP MA Antagonist DMD1FTP RN Agonist-induced internalization of CC chemokine receptor 5 as a mechanism to inhibit HIV replication. J Pharmacol Exp Ther. 2011 Jun;337(3):655-62. DMD1FTP RU https://pubmed.ncbi.nlm.nih.gov/21389095 DM5FZH4 DI DM5FZH4 DM5FZH4 DN ProstaVac DM5FZH4 MI TTS78AZ DM5FZH4 MN Prostate specific antigen (KLK3) DM5FZH4 MT DTT DM5FZH4 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2373). DM5FZH4 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2373 DMVU8RW DI DMVU8RW DMVU8RW DN PRT4445 DMVU8RW MI TTCIHJA DMVU8RW MN Coagulation factor Xa (F10) DMVU8RW MT DTT DMVU8RW MA Modulator DMVU8RW RN Semuloparin for the prevention of venous thromboembolic events in cancer patients. Drugs Today (Barc). 2012 Jul;48(7):451-7. DMVU8RW RU https://pubmed.ncbi.nlm.nih.gov/22844656 DMEH641 DI DMEH641 DMEH641 DN PRX-302 DMEH641 MI TTS78AZ DMEH641 MN Prostate specific antigen (KLK3) DMEH641 MT DTT DMEH641 MA Modulator DMEH641 RN Phase 1 and 2 studies demonstrate the safety and efficacy of intraprostatic injection of PRX302 for the targeted treatment of lower urinary tract symptoms secondary to benign prostatic hyperplasia. Eur Urol. 2011 May;59(5):747-54. DMEH641 RU https://pubmed.ncbi.nlm.nih.gov/21129846 DMIZJ8M DI DMIZJ8M DMIZJ8M DN Psoralen DMIZJ8M MI TT3WG5C DMIZJ8M MN Monoamine oxidase type A (MAO-A) DMIZJ8M MT DTT DMIZJ8M MA Inhibitor DMIZJ8M RN Inhibition of rat brain monoamine oxidase activities by psoralen and isopsoralen: implications for the treatment of affective disorders. Pharmacol Toxicol. 2001 Feb;88(2):75-80. DMIZJ8M RU https://pubmed.ncbi.nlm.nih.gov/11169165 DMIZJ8M DI DMIZJ8M DMIZJ8M DN Psoralen DMIZJ8M MI TTGP7BY DMIZJ8M MN Monoamine oxidase type B (MAO-B) DMIZJ8M MT DTT DMIZJ8M MA Inhibitor DMIZJ8M RN Inhibition of rat brain monoamine oxidase activities by psoralen and isopsoralen: implications for the treatment of affective disorders. Pharmacol Toxicol. 2001 Feb;88(2):75-80. DMIZJ8M RU https://pubmed.ncbi.nlm.nih.gov/11169165 DMTSN8L DI DMTSN8L DMTSN8L DN PT005 DMTSN8L MI TT2CJVK DMTSN8L MN Adrenergic receptor beta-2 (ADRB2) DMTSN8L MT DTT DMTSN8L MA Agonist DMTSN8L RN Clinical pipeline report, company report or official report of Pearl Therapeutics. DMTSN8L RU http://www.pearltherapeutics.com/PT005 DML1KTO DI DML1KTO DML1KTO DN PT2977 DML1KTO MI TTDMLNT DML1KTO MN Hypoxia-inducible factor 2 alpha (HIF-2A) DML1KTO MT DTT DML1KTO MA Inhibitor DML1KTO RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DML1KTO RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DMMJ63A DI DMMJ63A DMMJ63A DN PT-304 DMMJ63A MI TT84ETX DMMJ63A MN Human immunodeficiency virus Reverse transcriptase (HIV RT) DMMJ63A MT DTT DMMJ63A MA Inhibitor DMMJ63A RN Phenethylthiazolethiourea (PETT) compounds, a new class of HIV-1 reverse transcriptase inhibitors. 1. Synthesis and basic structure-activity relati... J Med Chem. 1995 Dec 8;38(25):4929-36. DMMJ63A RU https://pubmed.ncbi.nlm.nih.gov/8523406 DMVDCGZ DI DMVDCGZ DMVDCGZ DN Pyridoxamine DMVDCGZ MI TTMO9HF DMVDCGZ MN Advanced glycosylation end product receptor (AGER) DMVDCGZ MT DTT DMVDCGZ MA Inhibitor DMVDCGZ RN Pyridoxamine, an inhibitor of advanced glycation end product (AGE) formation ameliorates insulin resistance in obese, type 2 diabetic mice. Protein Pept Lett. 2010 Sep;17(9):1177-81. DMVDCGZ RU https://pubmed.ncbi.nlm.nih.gov/20441560 DMVDCGZ DI DMVDCGZ DMVDCGZ DN Pyridoxamine DMVDCGZ MI DE3Z1RA DMVDCGZ MN Pyridoxamine-phosphate oxidase (PNPO) DMVDCGZ MT DME DMVDCGZ MA Metabolism DMVDCGZ RN An LC-MS/MS-based method for the quantification of pyridox(am)ine 5'-phosphate oxidase activity in dried blood spots from patients with epilepsy. Anal Chem. 2017 Sep 5;89(17):8892-8900. DMVDCGZ RU https://www.ncbi.nlm.nih.gov/pubmed/?term=28782931 DMPCFXN DI DMPCFXN DMPCFXN DN QAW-039 DMPCFXN MI TTNVEIR DMPCFXN MN Prostaglandin D2 receptor (PTGDR) DMPCFXN MT DTT DMPCFXN MA Antagonist DMPCFXN RN Effect Of QAW039, An Oral Prostaglandin D2 Receptor (DP2/CRTh2) Antagonist, Upon Sputum And Bronchial Eosinophilic Inflammation And Clinical Outcomes In Treatment-Resistant Asthma: A Phase 2a Randomized Placebo-Controlled Trial. American Thoracic Society Journals. 2015. DMPCFXN RU http://www.atsjournals.org/doi/abs/10.1164/ajrccm-conference.2015.191.1_MeetingAbstracts.A6361 DMDU5Y2 DI DMDU5Y2 DMDU5Y2 DN QPI-1002 DMDU5Y2 MI TT7SBF5 DMDU5Y2 MN Cellular tumor antigen p53 (TP53) DMDU5Y2 MT DTT DMDU5Y2 MA Modulator DMDU5Y2 RN Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41. DMDU5Y2 RU https://www.ncbi.nlm.nih.gov/pubmed/15950434 DMUWXEB DI DMUWXEB DMUWXEB DN QPI-1007 DMUWXEB MI TT12VNG DMUWXEB MN Caspase 2 messenger RNA (CASP2 mRNA) DMUWXEB MT DTT DMUWXEB RN Toxicological and pharmacokinetic properties of QPI-1007, a chemically modified synthetic siRNA targeting caspase 2 mRNA, following intravitreal injection. Nucleic Acid Ther. 2014 Aug;24(4):258-66. DMUWXEB RU https://pubmed.ncbi.nlm.nih.gov/25054518 DMDCQW0 DI DMDCQW0 DMDCQW0 DN Quinotolast DMDCQW0 MI TT7KY5U DMDCQW0 MN Histamine/peptide leukotriene release (His/p-LT rele) DMDCQW0 MT DTT DMDCQW0 MA Modulator DMDCQW0 RN Effects of quinotolast, a new orally active antiallergic drug, on experimental allergic models. Jpn J Pharmacol. 1993 Sep;63(1):73-81. DMDCQW0 RU https://pubmed.ncbi.nlm.nih.gov/7505860 DMSFX75 DI DMSFX75 DMSFX75 DN QVA-149 DMSFX75 MI TT2CJVK DMSFX75 MN Adrenergic receptor beta-2 (ADRB2) DMSFX75 MT DTT DMSFX75 MA Agonist DMSFX75 RN Emerging drugs in chronic obstructive pulmonary disease. Expert Opin Emerg Drugs. 2009 Mar;14(1):181-94. DMSFX75 RU https://pubmed.ncbi.nlm.nih.gov/19265487 DM4K9WH DI DM4K9WH DM4K9WH DN R1678 DM4K9WH MI TTHJTF7 DM4K9WH MN Glycine transporter GlyT-1 (SLC6A9) DM4K9WH MT DTT DM4K9WH MA Blocker DM4K9WH RN Clinical pipeline report, company report or official report of Roche (2009). DM4K9WH RU http://www.roche.com/research_and_development/pipeline/roche_pharma_pipeline.htm DM9Z4N5 DI DM9Z4N5 DM9Z4N5 DN RA101495 DM9Z4N5 MI TTKANGO DM9Z4N5 MN Complement C5 (CO5) DM9Z4N5 MT DTT DM9Z4N5 MA Inhibitor DM9Z4N5 RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DM9Z4N5 RU http://phrma-docs.phrma.org/files/dmfile/MID_Neurological-Disorders-Drug-List_2018.pdf DM8RLJ5 DI DM8RLJ5 DM8RLJ5 DN RAD-1901 DM8RLJ5 MI TTZAYWL DM8RLJ5 MN Estrogen receptor (ESR) DM8RLJ5 MT DTT DM8RLJ5 MA Modulator DM8RLJ5 RN RAD1901: a novel, orally bioavailable selective estrogen receptor degrader that demonstrates antitumor activity in breast cancer xenograft models. Anticancer Drugs. 2015 Oct;26(9):948-56. DM8RLJ5 RU https://pubmed.ncbi.nlm.nih.gov/26164151 DMN1ZEU DI DMN1ZEU DMN1ZEU DN Radiosensitizer gene therapy DMN1ZEU MI TTP3QRF DMN1ZEU MN Thymidine kinase 1 (TK1) DMN1ZEU MT DTT DMN1ZEU MA Inhibitor DMN1ZEU RN Pronounced antitumor effects and tumor radiosensitization of double suicide gene therapy. Clin Cancer Res. 1997 Nov;3(11):2081-8. DMN1ZEU RU https://pubmed.ncbi.nlm.nih.gov/9815600 DMWA74Y DI DMWA74Y DMWA74Y DN Radotinib DMWA74Y MI TTS7G69 DMWA74Y MN Fusion protein Bcr-Abl (Bcr-Abl) DMWA74Y MT DTT DMWA74Y MA Modulator DMWA74Y RN Danusertib, an aurora kinase inhibitor.Expert Opin Investig Drugs.2012 Mar;21(3):383-93. DMWA74Y RU https://www.ncbi.nlm.nih.gov/pubmed/22242557 DMFSHEM DI DMFSHEM DMFSHEM DN Ragaglitazar DMFSHEM MI TTJ584C DMFSHEM MN Peroxisome proliferator-activated receptor alpha (PPARA) DMFSHEM MT DTT DMFSHEM MA Modulator DMFSHEM RN Ragaglitazar: the pharmacokinetics, pharmacodynamics, and tolerability of a novel dual PPAR alpha and gamma agonist in healthy subjects and patients with type 2 diabetes. J Clin Pharmacol. 2003 Nov;43(11):1244-56. DMFSHEM RU https://pubmed.ncbi.nlm.nih.gov/14551179 DMFSHEM DI DMFSHEM DMFSHEM DN Ragaglitazar DMFSHEM MI TTZMAO3 DMFSHEM MN Peroxisome proliferator-activated receptor gamma (PPAR-gamma) DMFSHEM MT DTT DMFSHEM MA Modulator DMFSHEM RN Ragaglitazar: the pharmacokinetics, pharmacodynamics, and tolerability of a novel dual PPAR alpha and gamma agonist in healthy subjects and patients with type 2 diabetes. J Clin Pharmacol. 2003 Nov;43(11):1244-56. DMFSHEM RU https://pubmed.ncbi.nlm.nih.gov/14551179 DMUNMY0 DI DMUNMY0 DMUNMY0 DN Ralfinamide DMUNMY0 MI TTRK8B9 DMUNMY0 MN Sodium channel unspecific (NaC) DMUNMY0 MT DTT DMUNMY0 MA Blocker DMUNMY0 RN Emerging drugs in neuropathic pain. Expert Opin Emerg Drugs. 2007 Mar;12(1):113-26. DMUNMY0 RU https://pubmed.ncbi.nlm.nih.gov/17355217 DMUNMY0 DI DMUNMY0 DMUNMY0 DN Ralfinamide DMUNMY0 MI TT4FDG6 DMUNMY0 MN Voltage-gated calcium channel alpha Cav2.2 (CACNA1B) DMUNMY0 MT DTT DMUNMY0 MA Blocker DMUNMY0 RN Emerging drugs in neuropathic pain. Expert Opin Emerg Drugs. 2007 Mar;12(1):113-26. DMUNMY0 RU https://pubmed.ncbi.nlm.nih.gov/17355217 DMD5QRS DI DMD5QRS DMD5QRS DN Ranirestat DMD5QRS MI TTFBNVI DMD5QRS MN Aldose reductase (AKR1B1) DMD5QRS MT DTT DMD5QRS MA Inhibitor DMD5QRS RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2768). DMD5QRS RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2768 DMVKL3B DI DMVKL3B DMVKL3B DN Ravulizumab DMVKL3B MI TTN0GJ5 DMVKL3B MN HUMAN complement C5 protein (C5) DMVKL3B MT DTT DMVKL3B MA Inhibitor DMVKL3B RN Complement as a target in COVID-19 Nat Rev Immunol. 2020 Apr 23. DMVKL3B RU https://pubmed.ncbi.nlm.nih.gov/32327719 DMPJTZ1 DI DMPJTZ1 DMPJTZ1 DN RBP-7000 DMPJTZ1 MI TTEX248 DMPJTZ1 MN Dopamine D2 receptor (D2R) DMPJTZ1 MT DTT DMPJTZ1 MA Modulator DMPJTZ1 RN Population pharmacokinetics and prediction of dopamine D2 receptor occupancy after multiple doses of RBP-7000, a new sustained-release formulation of risperidone, in schizophrenia patients on stable oral risperidone treatment. Clin Pharmacokinet. 2014 Jun;53(6):533-43. DMPJTZ1 RU https://pubmed.ncbi.nlm.nih.gov/24464285 DMDZW8K DI DMDZW8K DMDZW8K DN RBT-101 DMDZW8K MI TTX4GLS DMDZW8K MN Mammalian target of rapamycin complex 1 (mTORC1) DMDZW8K MT DTT DMDZW8K MA Inhibitor DMDZW8K RN Constrained peptides' time to shine. Nat Rev Drug Discov. 2018 Jul 30;17(8):531-533. DMDZW8K RU https://pubmed.ncbi.nlm.nih.gov/30057410 DM2GHCR DI DM2GHCR DM2GHCR DN Rebamipide DM2GHCR MI DE4LYSA DM2GHCR MN Cytochrome P450 3A4 (CYP3A4) DM2GHCR MT DME DM2GHCR MA Metabolism DM2GHCR RN Involvement of cytochrome P450 in the metabolism of rebamipide by the human liver. Xenobiotica. 2002 Jul;32(7):573-86. DM2GHCR RU https://www.ncbi.nlm.nih.gov/pubmed/?term=12162853 DM2GHCR DI DM2GHCR DM2GHCR DN Rebamipide DM2GHCR MI TT5Y4EM DM2GHCR MN N-formyl peptide receptor (FPR1) DM2GHCR MT DTT DM2GHCR MA Antagonist DM2GHCR RN Rebamipide suppresses formyl-methionyl-leucyl-phenylalanine (fMLP)-induced superoxide production by inhibiting fMLP-receptor binding in human neutrophils. J Pharmacol Exp Ther. 2001 Apr;297(1):388-94. DM2GHCR RU https://pubmed.ncbi.nlm.nih.gov/11259567 DM8HVNR DI DM8HVNR DM8HVNR DN Recombinant acidic fibroblast growth factor DM8HVNR MI TT5HU6Z DM8HVNR MN Fibroblast growth factor (FGF) DM8HVNR MT DTT DM8HVNR MA Modulator DM8HVNR RN Molecular characterization of recombinant human acidic fibroblast growth factor produced in E. coli: comparative studies with human basic fibroblast growth factor. Mol Endocrinol. 1990 Jun;4(6):869-79. DM8HVNR RU https://pubmed.ncbi.nlm.nih.gov/1700280 DMOWQAF DI DMOWQAF DMOWQAF DN Recombinant human iduronate-2-sulfatase DMOWQAF MI TTNY2AP DMOWQAF MN Iduronate 2-sulfatase (IDS) DMOWQAF MT DTT DMOWQAF MA Modulator DMOWQAF RN The effect of recombinant human iduronate-2-sulfatase (Idursulfase) on growth in young patients with mucopolysaccharidosis type II. PLoS One. 2014 Jan 13;9(1):e85074. DMOWQAF RU https://pubmed.ncbi.nlm.nih.gov/24454794 DM7JFDO DI DM7JFDO DM7JFDO DN Recombinant von Willebrand factor/recombinant Factor VIII complex DM7JFDO MI TT1290U DM7JFDO MN Coagulation factor VIII (F8) DM7JFDO MT DTT DM7JFDO MA Modulator DM7JFDO RN 6 Factor VIII Concentrates, Factor VIII/von Willebrand Factor Concentrates, Factor IX Concentrates, Activated Prothrombin Complex Concentrates. Transfus Med Hemother. 2009 December; 36(6): 409-418. DM7JFDO RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2997296/ DM7JFDO DI DM7JFDO DM7JFDO DN Recombinant von Willebrand factor/recombinant Factor VIII complex DM7JFDO MI TT3SZBT DM7JFDO MN von Willebrand factor (VWF) DM7JFDO MT DTT DM7JFDO MA Modulator DM7JFDO RN 6 Factor VIII Concentrates, Factor VIII/von Willebrand Factor Concentrates, Factor IX Concentrates, Activated Prothrombin Complex Concentrates. Transfus Med Hemother. 2009 December; 36(6): 409-418. DM7JFDO RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2997296/ DM34GOF DI DM34GOF DM34GOF DN REL-1017 DM34GOF MI TT9IK2Z DM34GOF MN N-methyl-D-aspartate receptor (NMDAR) DM34GOF MT DTT DM34GOF MA Antagonist DM34GOF RN N-Methyl-D-aspartate receptor antagonist d-methadone produces rapid, mTORC1-dependent antidepressant effects. Neuropsychopharmacology. 2019 Dec;44(13):2230-2238. DM34GOF RU https://pubmed.ncbi.nlm.nih.gov/31454827 DMOWINT DI DMOWINT DMOWINT DN Reloxaliase DMOWINT MI TTMDQIJ DMOWINT MN Oxalate absorption (Oxalate absor) DMOWINT MT DTT DMOWINT MA Replacement DMOWINT RN Clinical pipeline report, company report or official report of Allena Pharmaceuticals. DMOWINT RU https://www.allenapharma.com/reloxaliase DM3YXP8 DI DM3YXP8 DM3YXP8 DN Remacemide DM3YXP8 MI DE4LYSA DM3YXP8 MN Cytochrome P450 3A4 (CYP3A4) DM3YXP8 MT DME DM3YXP8 MA Metabolism DM3YXP8 RN Influence of cytochrome P450 induction on the pharmacokinetics and pharmacodynamics of remacemide hydrochloride. Epilepsy Res. 2002 May;49(3):247-54. DM3YXP8 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=12076846 DM3YXP8 DI DM3YXP8 DM3YXP8 DN Remacemide DM3YXP8 MI TT9IK2Z DM3YXP8 MN N-methyl-D-aspartate receptor (NMDAR) DM3YXP8 MT DTT DM3YXP8 MA Agonist DM3YXP8 RN Glutamate- and GABA-based CNS therapeutics. Curr Opin Pharmacol. 2006 Feb;6(1):7-17. DM3YXP8 RU https://pubmed.ncbi.nlm.nih.gov/16377242 DM49IGE DI DM49IGE DM49IGE DN Remdesivir DM49IGE MI TTV1095 DM49IGE MN COVID-19 RNA-directed RNA polymerase (RdRp) DM49IGE MT DTT DM49IGE MA Inhibitor DM49IGE RN Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro. Cell Res. 2020 Mar;30(3):269-271. DM49IGE RU https://pubmed.ncbi.nlm.nih.gov/32020029 DM49IGE DI DM49IGE DM49IGE DN Remdesivir DM49IGE MI TTOA6YT DM49IGE MN MERS-CoV RNA-directed RNA polymerase (RdRp) DM49IGE MT DTT DM49IGE MA Inhibitor DM49IGE RN Comparative therapeutic efficacy of remdesivir and combination lopinavir, ritonavir, and interferon beta against MERS-CoV. Nat Commun. 2020 Jan 10;11(1):222. DM49IGE RU https://pubmed.ncbi.nlm.nih.gov/31924756 DM49IGE DI DM49IGE DM49IGE DN Remdesivir DM49IGE MI TTKXI53 DM49IGE MN SARS-CoV RNA-directed RNA polymerase (RdRp) DM49IGE MT DTT DM49IGE MA Inhibitor DM49IGE RN Comparative therapeutic efficacy of remdesivir and combination lopinavir, ritonavir, and interferon beta against MERS-CoV. Nat Commun. 2020 Jan 10;11(1):222. DM49IGE RU https://pubmed.ncbi.nlm.nih.gov/31924756 DM7HQNX DI DM7HQNX DM7HQNX DN Renzapride DM7HQNX MI TTNXLKE DM7HQNX MN 5-HT 3 receptor (5HT3R) DM7HQNX MT DTT DM7HQNX MA Modulator DM7HQNX RN Pharmacology and metabolism of renzapride : a novel therapeutic agent for the potential treatment of irritable bowel syndrome. Drugs R D. 2008;9(1):37-63. DM7HQNX RU https://www.ncbi.nlm.nih.gov/pubmed/18095752 DM7HQNX DI DM7HQNX DM7HQNX DN Renzapride DM7HQNX MI TT07C3Y DM7HQNX MN 5-HT 4 receptor (HTR4) DM7HQNX MT DTT DM7HQNX MA Modulator DM7HQNX RN Pharmacology and metabolism of renzapride : a novel therapeutic agent for the potential treatment of irritable bowel syndrome. Drugs R D. 2008;9(1):37-63. DM7HQNX RU https://www.ncbi.nlm.nih.gov/pubmed/18095752 DMVBA7I DI DMVBA7I DMVBA7I DN Reparixin DMVBA7I MI TTMWT8Z DMVBA7I MN C-X-C chemokine receptor type 1 (CXCR1) DMVBA7I MT DTT DMVBA7I MA Modulator DMVBA7I RN 2-Arylpropionic CXC chemokine receptor 1 (CXCR1) ligands as novel noncompetitive CXCL8 inhibitors. J Med Chem. 2005 Jun 30;48(13):4312-31. DMVBA7I RU https://pubmed.ncbi.nlm.nih.gov/15974585 DMVBA7I DI DMVBA7I DMVBA7I DN Reparixin DMVBA7I MI TT30C9G DMVBA7I MN C-X-C chemokine receptor type 2 (CXCR2) DMVBA7I MT DTT DMVBA7I MA Modulator DMVBA7I RN 2-Arylpropionic CXC chemokine receptor 1 (CXCR1) ligands as novel noncompetitive CXCL8 inhibitors. J Med Chem. 2005 Jun 30;48(13):4312-31. DMVBA7I RU https://pubmed.ncbi.nlm.nih.gov/15974585 DMDEJX9 DI DMDEJX9 DMDEJX9 DN Reproxalap DMDEJX9 MI TTZEX7Y DMDEJX9 MN Malondialdehyde (MDA) DMDEJX9 MT DTT DMDEJX9 MA Inhibitor DMDEJX9 RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMDEJX9 RU http://phrma-docs.phrma.org/files/dmfile/MID_Skin_Diseases_2018_9_FINAL.pdf DMFMWYC DI DMFMWYC DMFMWYC DN Resatorvid DMFMWYC MI TTISGCA DMFMWYC MN Toll-like receptor 4 (TLR4) DMFMWYC MT DTT DMFMWYC MA Antagonist DMFMWYC RN Clinical pipeline report, company report or official report of Takeda (2009). DMFMWYC RU http://www.takeda.com/pdf/usr/default/10_1_34992_2.pdf DM3RWXL DI DM3RWXL DM3RWXL DN Resveratrol DM3RWXL MI DTI7UX6 DM3RWXL MN Breast cancer resistance protein (ABCG2) DM3RWXL MT DTP DM3RWXL MA Substrate DM3RWXL RN The effect of low pH on breast cancer resistance protein (ABCG2)-mediated transport of methotrexate, 7-hydroxymethotrexate, methotrexate diglutamate, folic acid, mitoxantrone, topotecan, and resveratrol in in vitro drug transport models. Mol Pharmacol. 2007 Jan;71(1):240-9. DM3RWXL RU http://www.ncbi.nlm.nih.gov/pubmed/17032904 DM3RWXL DI DM3RWXL DM3RWXL DN Resveratrol DM3RWXL MI DEJGDUW DM3RWXL MN Cytochrome P450 1A2 (CYP1A2) DM3RWXL MT DME DM3RWXL MA Metabolism DM3RWXL RN Involvement of cytochrome P450 1A2 in the biotransformation of trans-resveratrol in human liver microsomes. Biochem Pharmacol. 2004 Aug 15;68(4):773-82. DM3RWXL RU https://www.ncbi.nlm.nih.gov/pubmed/?term=15276085 DM3RWXL DI DM3RWXL DM3RWXL DN Resveratrol DM3RWXL MI DTSYQGK DM3RWXL MN Multidrug resistance-associated protein 1 (ABCC1) DM3RWXL MT DTP DM3RWXL MA Substrate DM3RWXL RN Human intestinal transporter database: QSAR modeling and virtual profiling of drug uptake, efflux and interactions. Pharm Res. 2013 Apr;30(4):996-1007. DM3RWXL RU https://doi.org/10.1007/s11095-012-0935-x DM3RWXL DI DM3RWXL DM3RWXL DN Resveratrol DM3RWXL MI DTCSGPB DM3RWXL MN Multidrug resistance-associated protein 4 (ABCC4) DM3RWXL MT DTP DM3RWXL MA Substrate DM3RWXL RN Human intestinal transporter database: QSAR modeling and virtual profiling of drug uptake, efflux and interactions. Pharm Res. 2013 Apr;30(4):996-1007. DM3RWXL RU https://doi.org/10.1007/s11095-012-0935-x DM3RWXL DI DM3RWXL DM3RWXL DN Resveratrol DM3RWXL MI TTUF2HO DM3RWXL MN NAD-dependent deacetylase sirtuin-1 (SIRT1) DM3RWXL MT DTT DM3RWXL MA Inhibitor DM3RWXL RN Sirtuin modulators: an updated patent review (2012 - 2014).Expert Opin Ther Pat. 2015 Jan;25(1):5-15. DM3RWXL RU https://www.ncbi.nlm.nih.gov/pubmed/25435179 DM3RWXL DI DM3RWXL DM3RWXL DN Resveratrol DM3RWXL MI DEZWDKE DM3RWXL MN NADPH-dependent curcumin reductase (curA) DM3RWXL MT DME DM3RWXL MA Metabolism DM3RWXL RN Discovery of the curcumin metabolic pathway involving a unique enzyme in an intestinal microorganism. Proc Natl Acad Sci U S A. 2011 Apr 19;108(16):6615-20. DM3RWXL RU https://pubmed.ncbi.nlm.nih.gov/21467222 DM3RWXL DI DM3RWXL DM3RWXL DN Resveratrol DM3RWXL MI TT8NGED DM3RWXL MN Prostaglandin G/H synthase 1 (COX-1) DM3RWXL MT DTT DM3RWXL MA Modulator DM3RWXL RN Resveratrol is a peroxidase-mediated inactivator of COX-1 but not COX-2: a mechanistic approach to the design of COX-1 selective agents. J Biol Chem. 2004 May 21;279(21):22727-37. DM3RWXL RU https://pubmed.ncbi.nlm.nih.gov/15020596 DM3RWXL DI DM3RWXL DM3RWXL DN Resveratrol DM3RWXL MI DEYMAD4 DM3RWXL MN Sulfotransferase 1C2 (SULT1C2) DM3RWXL MT DME DM3RWXL MA Metabolism DM3RWXL RN Correlation of reactive oxygen species levels with resveratrol sensitivities of anaplastic thyroid cancer cells. Oxid Med Cell Longev. 2018 Jul 10;2018:6235417. DM3RWXL RU https://pubmed.ncbi.nlm.nih.gov/30116486 DMOYGZF DI DMOYGZF DMOYGZF DN Retosiban DMOYGZF MI TTSCIUP DMOYGZF MN Oxytocin receptor (OTR) DMOYGZF MT DTT DMOYGZF MA Modulator DMOYGZF RN The Effect of an Oxytocin Receptor Antagonist (Retosiban, GSK221149A) on the Response of Human Myometrial Explants to Prolonged Mechanical Stretch.Endocrinology.2015 Oct;156(10):3511-6. DMOYGZF RU https://www.ncbi.nlm.nih.gov/pubmed/26207346 DM5E73H DI DM5E73H DM5E73H DN Revusiran DM5E73H MI TTPOYU7 DM5E73H MN Transthyretin messenger RNA (TTR mRNA) DM5E73H MT DTT DM5E73H RN Clinical pipeline report, company report or official report of Alnylam Pharmaceuticals, Inc. DM5E73H RU http://www.alnylam.com/product-pipeline/ttr-amyloidosis-fac/ DMQ4CSX DI DMQ4CSX DMQ4CSX DN Rezafungin DMQ4CSX MI TT0SFXH DMQ4CSX MN Fungal 1,3-beta-glucan synthase (Fung GSC2) DMQ4CSX MT DTT DMQ4CSX MA Inhibitor DMQ4CSX RN Antifungal drugs: What brings the future?. Med Mycol. 2019 Jun 1;57(Supplement_3):S328-S343. DMQ4CSX RU https://pubmed.ncbi.nlm.nih.gov/31292663 DMTQJE0 DI DMTQJE0 DMTQJE0 DN RG3638 DMTQJE0 MI TTNDSF4 DMTQJE0 MN Proto-oncogene c-Met (MET) DMTQJE0 MT DTT DMTQJE0 MA Modulator DMTQJE0 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1815). DMTQJE0 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1815 DMER75Y DI DMER75Y DMER75Y DN RG6013 DMER75Y MI TTFEZ5Q DMER75Y MN Coagulation factor IX (F9) DMER75Y MT DTT DMER75Y RN Anti-factor IXa/X bispecific antibody (ACE910): hemostatic potency against ongoing bleeds in a hemophilia A model and the possibility of routine supplementation. J Thromb Haemost. 2014 Feb;12(2):206-13. DMER75Y RU https://pubmed.ncbi.nlm.nih.gov/24738137 DMJRFYB DI DMJRFYB DMJRFYB DN RG7201 DMJRFYB MI TTN7Y4P DMJRFYB MN Sodium/glucose cotransporter 2 (SLC5A4) DMJRFYB MT DTT DMJRFYB MA Modulator DMJRFYB RN Efficacy and safety of monotherapy with the novel sodium/glucose cotransporter-2 inhibitor tofogliflozin in Japanese patients with type 2 diabetes mellitus: a combined Phase 2 and 3 randomized, placebo-controlled, double-blind, parallel-group comparative study. Cardiovasc Diabetol. 2014 Mar 28;13:65. DMJRFYB RU https://pubmed.ncbi.nlm.nih.gov/24678906 DMF5GZI DI DMF5GZI DMF5GZI DN RG7388 DMF5GZI MI TT0JESD DMF5GZI MN Erbb4 tyrosine kinase receptor (Erbb-4) DMF5GZI MT DTT DMF5GZI MA Inhibitor DMF5GZI RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1799). DMF5GZI RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1799 DMF5GZI DI DMF5GZI DMF5GZI DN RG7388 DMF5GZI MI TT08GJW DMF5GZI MN Ubiquitin-protein ligase E3 Mdm2 (MDM2) DMF5GZI MT DTT DMF5GZI MA Modulator DMF5GZI RN Pre-clinical evaluation of the MDM2-p53 antagonist RG7388 alone and in combination with chemotherapy in neuroblastoma. Oncotarget. 2015 Apr 30;6(12):10207-21. DMF5GZI RU https://pubmed.ncbi.nlm.nih.gov/25844600 DMDVAFP DI DMDVAFP DMDVAFP DN RG7601 DMDVAFP MI TTJGNVC DMDVAFP MN Apoptosis regulator Bcl-2 (BCL-2) DMDVAFP MT DTT DMDVAFP MA Modulator DMDVAFP RN ABT-199, a potent and selective BCL-2 inhibitor, achieves antitumor activity while sparing platelets. Nat Med. 2013 Feb;19(2):202-8. DMDVAFP RU https://pubmed.ncbi.nlm.nih.gov/23291630 DMGOTK4 DI DMGOTK4 DMGOTK4 DN Rhumab Beta7 DMGOTK4 MI TTLT9XQ DMGOTK4 MN Integrin beta-7 (ITGB7) DMGOTK4 MT DTT DMGOTK4 RN A randomised phase I study of etrolizumab (rhuMAb beta7) in moderate to severe ulcerative colitis. Gut. 2013 Aug;62(8):1122-30. DMGOTK4 RU https://pubmed.ncbi.nlm.nih.gov/22717454 DMLHEU7 DI DMLHEU7 DMLHEU7 DN Ridaforolimus DMLHEU7 MI TTCJG29 DMLHEU7 MN Serine/threonine-protein kinase mTOR (mTOR) DMLHEU7 MT DTT DMLHEU7 MA Inhibitor DMLHEU7 RN A novel c-Met inhibitor, MK8033, synergizes with carboplatin plus paclitaxel to inhibit ovarian cancer cell growth. Oncol Rep. 2013 May;29(5):2011-8. DMLHEU7 RU https://pubmed.ncbi.nlm.nih.gov/23467907 DMYXOHV DI DMYXOHV DMYXOHV DN Rifalazil DMYXOHV MI TTIJ5EB DMYXOHV MN Bacterial RNA polymerase switch region (Bact RNAP-SR) DMYXOHV MT DTT DMYXOHV MA Inhibitor DMYXOHV RN Novel agents in the management of Mycobacterium tuberculosis disease. Curr Med Chem. 2007;14(18):2000-8. DMYXOHV RU https://pubmed.ncbi.nlm.nih.gov/17691942 DMYXOHV DI DMYXOHV DMYXOHV DN Rifalazil DMYXOHV MI DE4LYSA DMYXOHV MN Cytochrome P450 3A4 (CYP3A4) DMYXOHV MT DME DMYXOHV MA Metabolism DMYXOHV RN Identification of enzymes responsible for rifalazil metabolism in human liver microsomes. Xenobiotica. 2000 Jun;30(6):565-74. DMYXOHV RU https://www.ncbi.nlm.nih.gov/pubmed/?term=10923859 DMKTS2M DI DMKTS2M DMKTS2M DN Rifaximin DR DMKTS2M MI TTHKJLN DMKTS2M MN DNA-directed RNA polymerase (RNAP) DMKTS2M MT DTT DMKTS2M MA Inhibitor DMKTS2M RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMKTS2M RU http://phrma-docs.phrma.org/files/dmfile/medicines-in-development-drug-list-autoimmune-diseases.pdf DMOSTXF DI DMOSTXF DMOSTXF DN Rigosertib DMOSTXF MI TTHBTOP DMOSTXF MN PI3-kinase gamma (PIK3CG) DMOSTXF MT DTT DMOSTXF MA Modulator DMOSTXF RN Phase I study of oral rigosertib (ON 01910.Na), a dual inhibitor of the PI3K and Plk1 pathways, in adult patients with advanced solid malignancies. Clin Cancer Res. 2014 Mar 15;20(6):1656-65. DMOSTXF RU https://pubmed.ncbi.nlm.nih.gov/24493827 DMOSTXF DI DMOSTXF DMOSTXF DN Rigosertib DMOSTXF MI TTIYVQP DMOSTXF MN Polo-like kinase 1 (PLK1) DMOSTXF MT DTT DMOSTXF MA Modulator DMOSTXF RN Phase I study of oral rigosertib (ON 01910.Na), a dual inhibitor of the PI3K and Plk1 pathways, in adult patients with advanced solid malignancies. Clin Cancer Res. 2014 Mar 15;20(6):1656-65. DMOSTXF RU https://pubmed.ncbi.nlm.nih.gov/24493827 DMGTCI0 DI DMGTCI0 DMGTCI0 DN Rilimogene galvacirepvec DMGTCI0 MI TTS78AZ DMGTCI0 MN Prostate specific antigen (KLK3) DMGTCI0 MT DTT DMGTCI0 MA Modulator DMGTCI0 RN Overall survival analysis of a phase II randomized controlled trial of a Poxviral-based PSA-targeted immunotherapy in metastatic castration-resistant prostate cancer. J Clin Oncol. 2010 Mar 1;28(7):1099-105. DMGTCI0 RU https://pubmed.ncbi.nlm.nih.gov/20100959 DMP6IMQ DI DMP6IMQ DMP6IMQ DN Rindopepimut DMP6IMQ MI TTGKNB4 DMP6IMQ MN Epidermal growth factor receptor (EGFR) DMP6IMQ MT DTT DMP6IMQ MA Modulator DMP6IMQ RN Rindopepimut, a 14-mer injectable peptide vaccine against EGFRvIII for the potential treatment of glioblastoma multiforme. Curr Opin Mol Ther. 2010 Dec;12(6):741-54. DMP6IMQ RU https://pubmed.ncbi.nlm.nih.gov/21154166 DMYX7VI DI DMYX7VI DMYX7VI DN Rintatolimod DMYX7VI MI TTD24Y0 DMYX7VI MN Toll-like receptor 3 (TLR3) DMYX7VI MT DTT DMYX7VI RN A double-blind, placebo-controlled, randomized, clinical trial of the TLR-3 agonist rintatolimod in severe cases of chronic fatigue syndrome. PLoS One. 2012;7(3):e31334. DMYX7VI RU https://pubmed.ncbi.nlm.nih.gov/22431963 DM13V0P DI DM13V0P DM13V0P DN Rivoceranib DM13V0P MI TTUTJGQ DM13V0P MN Vascular endothelial growth factor receptor 2 (KDR) DM13V0P MT DTT DM13V0P MA Antagonist DM13V0P RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DM13V0P RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DMBY31K DI DMBY31K DMBY31K DN Rivoglitazone DMBY31K MI DES5XRU DMBY31K MN Cytochrome P450 2C8 (CYP2C8) DMBY31K MT DME DMBY31K MA Metabolism DMBY31K RN In vitro metabolism of rivoglitazone, a novel peroxisome proliferator-activated receptor gama agonist, in rat, monkey, and human liver microsomes and freshly isolated hepatocytes. Drug Metab Dispos. 2011 Jul;39(7):1311-9. DMBY31K RU https://www.ncbi.nlm.nih.gov/pubmed/?term=21511943 DMBY31K DI DMBY31K DMBY31K DN Rivoglitazone DMBY31K MI DE4LYSA DMBY31K MN Cytochrome P450 3A4 (CYP3A4) DMBY31K MT DME DMBY31K MA Metabolism DMBY31K RN Effects of gemfibrozil, itraconazole, and their combination on the pharmacokinetics of pioglitazone. Clin Pharmacol Ther. 2005 May;77(5):404-14. DMBY31K RU https://www.ncbi.nlm.nih.gov/pubmed/?term=15900286 DMBY31K DI DMBY31K DMBY31K DN Rivoglitazone DMBY31K MI TTZMAO3 DMBY31K MN Peroxisome proliferator-activated receptor gamma (PPAR-gamma) DMBY31K MT DTT DMBY31K MA Agonist DMBY31K RN A randomized-controlled trial to investigate the effects of rivoglitazone, a novel PPAR gamma agonist on glucose-lipid control in type 2 diabetes. Diabetes Obes Metab. 2011 Sep;13(9):806-13. DMBY31K RU https://pubmed.ncbi.nlm.nih.gov/21492364 DMBY31K DI DMBY31K DMBY31K DN Rivoglitazone DMBY31K MI DEF2WXN DMBY31K MN UDP-glucuronosyltransferase 1A3 (UGT1A3) DMBY31K MT DME DMBY31K MA Metabolism DMBY31K RN In vitro metabolism of rivoglitazone, a novel peroxisome proliferator-activated receptor gama agonist, in rat, monkey, and human liver microsomes and freshly isolated hepatocytes. Drug Metab Dispos. 2011 Jul;39(7):1311-9. DMBY31K RU https://www.ncbi.nlm.nih.gov/pubmed/?term=21511943 DMBY31K DI DMBY31K DMBY31K DN Rivoglitazone DMBY31K MI DEB3CV1 DMBY31K MN UDP-glucuronosyltransferase 2B7 (UGT2B7) DMBY31K MT DME DMBY31K MA Metabolism DMBY31K RN In vitro metabolism of rivoglitazone, a novel peroxisome proliferator-activated receptor gama agonist, in rat, monkey, and human liver microsomes and freshly isolated hepatocytes. Drug Metab Dispos. 2011 Jul;39(7):1311-9. DMBY31K RU https://www.ncbi.nlm.nih.gov/pubmed/?term=21511943 DMVQ5X1 DI DMVQ5X1 DMVQ5X1 DN Roclatan DMVQ5X1 MI TTAWNKZ DMVQ5X1 MN Norepinephrine transporter (NET) DMVQ5X1 MT DTT DMVQ5X1 MA Modulator DMVQ5X1 RN Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41. DMVQ5X1 RU https://www.ncbi.nlm.nih.gov/pubmed/15950434 DMVQ5X1 DI DMVQ5X1 DMVQ5X1 DN Roclatan DMVQ5X1 MI TTMQO60 DMVQ5X1 MN Rho-associated protein kinase (ROCK) DMVQ5X1 MT DTT DMVQ5X1 MA Modulator DMVQ5X1 RN Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41. DMVQ5X1 RU https://www.ncbi.nlm.nih.gov/pubmed/15950434 DMSZPR3 DI DMSZPR3 DMSZPR3 DN Rolofylline DMSZPR3 MI TTK25J1 DMSZPR3 MN Adenosine A1 receptor (ADORA1) DMSZPR3 MT DTT DMSZPR3 MA Antagonist DMSZPR3 RN Association between the PDE4D gene and ischaemic stroke in the Chinese Han population. Clin Sci (Lond). 2009 Aug 17;117(7):265-72. DMSZPR3 RU https://pubmed.ncbi.nlm.nih.gov/19196240 DMSZPR3 DI DMSZPR3 DMSZPR3 DN Rolofylline DMSZPR3 MI DE4LYSA DMSZPR3 MN Cytochrome P450 3A4 (CYP3A4) DMSZPR3 MT DME DMSZPR3 MA Metabolism DMSZPR3 RN Simultaneous pharmacokinetic model for rolofylline and both M1-trans and M1-cis metabolites. AAPS J. 2013 Apr;15(2):498-504. DMSZPR3 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=23355301 DMPIDXT DI DMPIDXT DMPIDXT DN Rosiglitazone + metformin DMPIDXT MI TTPS3C0 DMPIDXT MN Aurora kinase A (AURKA) DMPIDXT MT DTT DMPIDXT MA Inhibitor DMPIDXT RN A comparison of physicochemical property profiles of marketed oral drugs and orally bioavailable anti-cancer protein kinase inhibitors in clinical development. Curr Top Med Chem. 2007;7(14):1408-22. DMPIDXT RU https://pubmed.ncbi.nlm.nih.gov/17692029 DMPIDXT DI DMPIDXT DMPIDXT DN Rosiglitazone + metformin DMPIDXT MI TT5LS6T DMPIDXT MN Aurora kinase B (AURKB) DMPIDXT MT DTT DMPIDXT MA Inhibitor DMPIDXT RN A comparison of physicochemical property profiles of marketed oral drugs and orally bioavailable anti-cancer protein kinase inhibitors in clinical development. Curr Top Med Chem. 2007;7(14):1408-22. DMPIDXT RU https://pubmed.ncbi.nlm.nih.gov/17692029 DMPIDXT DI DMPIDXT DMPIDXT DN Rosiglitazone + metformin DMPIDXT MI TTRLW2X DMPIDXT MN Fibroblast growth factor receptor 1 (FGFR1) DMPIDXT MT DTT DMPIDXT MA Inhibitor DMPIDXT RN A comparison of physicochemical property profiles of marketed oral drugs and orally bioavailable anti-cancer protein kinase inhibitors in clinical development. Curr Top Med Chem. 2007;7(14):1408-22. DMPIDXT RU https://pubmed.ncbi.nlm.nih.gov/17692029 DMPIDXT DI DMPIDXT DMPIDXT DN Rosiglitazone + metformin DMPIDXT MI TTZMAO3 DMPIDXT MN Peroxisome proliferator-activated receptor gamma (PPAR-gamma) DMPIDXT MT DTT DMPIDXT MA Agonist DMPIDXT RN Clinical pipeline report, company report or official report of GlaxoSmithKline (2009). DMPIDXT RU http://www.gsk.com/investors/product_pipeline/docs/gsk-pipeline-feb09.pdf DMPIDXT DI DMPIDXT DMPIDXT DN Rosiglitazone + metformin DMPIDXT MI TTI2WET DMPIDXT MN Platelet-derived growth factor receptor (PDGFR) DMPIDXT MT DTT DMPIDXT MA Inhibitor DMPIDXT RN A comparison of physicochemical property profiles of marketed oral drugs and orally bioavailable anti-cancer protein kinase inhibitors in clinical development. Curr Top Med Chem. 2007;7(14):1408-22. DMPIDXT RU https://pubmed.ncbi.nlm.nih.gov/17692029 DMPIDXT DI DMPIDXT DMPIDXT DN Rosiglitazone + metformin DMPIDXT MI TTUTJGQ DMPIDXT MN Vascular endothelial growth factor receptor 2 (KDR) DMPIDXT MT DTT DMPIDXT MA Inhibitor DMPIDXT RN A comparison of physicochemical property profiles of marketed oral drugs and orally bioavailable anti-cancer protein kinase inhibitors in clinical development. Curr Top Med Chem. 2007;7(14):1408-22. DMPIDXT RU https://pubmed.ncbi.nlm.nih.gov/17692029 DM18B72 DI DM18B72 DM18B72 DN Rosiglitazone + simvastatin DM18B72 MI TTZMAO3 DM18B72 MN Peroxisome proliferator-activated receptor gamma (PPAR-gamma) DM18B72 MT DTT DM18B72 MA Agonist DM18B72 RN Clinical pipeline report, company report or official report of GlaxoSmithKline (2009). DM18B72 RU http://www.gsk.com/investors/product_pipeline/docs/gsk-pipeline-feb09.pdf DMNGCAD DI DMNGCAD DMNGCAD DN Rova-T DMNGCAD MI TT1C9K6 DMNGCAD MN Delta-like protein 3 (DLL3) DMNGCAD MT DTT DMNGCAD MA Inhibitor DMNGCAD RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMNGCAD RU http://phrma-docs.phrma.org/sites/default/files/pdf/medicines-in-development-drug-list-rare-diseases.pdf DM9T8OF DI DM9T8OF DM9T8OF DN RQ-00000004 DM9T8OF MI TTLOKXP DM9T8OF MN Gastric H(+)/K(+) ATPase (Proton pump) DM9T8OF MT DTT DM9T8OF MA Modulator DM9T8OF RN N-(2-hydroxyethyl)-N,2-dimethyl-8-{[(4R)-5-methyl-3,4-dihydro-2H-chromen-4-yl]amino}imidazo[1,2-a]pyridine-6-carboxamide (PF-03716556), a novel, potent, and selective acid pump antagonist for the treatment of gastroesophageal reflux disease. J Pharmacol Exp Ther. 2009 Feb;328(2):671-9. DM9T8OF RU https://pubmed.ncbi.nlm.nih.gov/18981288 DMQM2FH DI DMQM2FH DMQM2FH DN RRx-001 DMQM2FH MI TT8E7Z0 DMQM2FH MN Free radical (FRD) DMQM2FH MT DTT DMQM2FH MA Modulator DMQM2FH RN Dinitroazetidines are a novel class of anticancer agents and hypoxia-activated radiation sensitizers developed from highly energetic materials. Cancer Res. 2012 May 15;72(10):2600-8. DMQM2FH RU https://pubmed.ncbi.nlm.nih.gov/22589277 DM62QTW DI DM62QTW DM62QTW DN RTB101 DM62QTW MI TT4GO0F DM62QTW MN CREB-regulated transcription coactivator 1 (TORC1) DM62QTW MT DTT DM62QTW MA Inhibitor DM62QTW RN Anti-ageing pipeline starts to mature.Nat Rev Drug Discov. 2018 Sep;17(9):609-612. DM62QTW RU https://pubmed.ncbi.nlm.nih.gov/30072728 DMDWU1S DI DMDWU1S DMDWU1S DN Rubitecan DMDWU1S MI TTGTQHC DMDWU1S MN DNA topoisomerase I (TOP1) DMDWU1S MT DTT DMDWU1S MA Inhibitor DMDWU1S RN Rubitecan. Expert Opin Investig Drugs. 2006 Jan;15(1):71-9. DMDWU1S RU https://pubmed.ncbi.nlm.nih.gov/16370935 DMDWU1S DI DMDWU1S DMDWU1S DN Rubitecan DMDWU1S MI DTCSGPB DMDWU1S MN Multidrug resistance-associated protein 4 (ABCC4) DMDWU1S MT DTP DMDWU1S MA Substrate DMDWU1S RN Human intestinal transporter database: QSAR modeling and virtual profiling of drug uptake, efflux and interactions. Pharm Res. 2013 Apr;30(4):996-1007. DMDWU1S RU https://doi.org/10.1007/s11095-012-0935-x DMQOCD8 DI DMQOCD8 DMQOCD8 DN RUBOXISTAURIN HYDROCHLORIDE DMQOCD8 MI TTYPXQF DMQOCD8 MN Protein kinase C beta (PRKCB) DMQOCD8 MT DTT DMQOCD8 MA Modulator DMQOCD8 RN Ruboxistaurin: LY 333531. Drugs R D. 2007;8(3):193-9. DMQOCD8 RU https://pubmed.ncbi.nlm.nih.gov/17472415 DM25TMP DI DM25TMP DM25TMP DN Rubraca rucaparib DM25TMP MI TTEBCY8 DM25TMP MN Poly [ADP-ribose] polymerase (PARP) DM25TMP MT DTT DM25TMP MA Inhibitor DM25TMP RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DM25TMP RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DM20KYR DI DM20KYR DM20KYR DN Ruxolitinib DM20KYR MI TTWKB01 DM20KYR MN HUMAN janus kinase 1 (JAK-1) DM20KYR MT DTT DM20KYR MA Inhibitor DM20KYR RN The Use of Anti-Inflammatory Drugs in the Treatment of People With Severe Coronavirus Disease 2019 (COVID-19): The Perspectives of Clinical Immunologists From China. Clin Immunol. 2020 May;214:108393. DM20KYR RU https://pubmed.ncbi.nlm.nih.gov/32222466 DM20KYR DI DM20KYR DM20KYR DN Ruxolitinib DM20KYR MI TT0F5HE DM20KYR MN HUMAN janus kinase 2 (JAK-2) DM20KYR MT DTT DM20KYR MA Inhibitor DM20KYR RN The Use of Anti-Inflammatory Drugs in the Treatment of People With Severe Coronavirus Disease 2019 (COVID-19): The Perspectives of Clinical Immunologists From China. Clin Immunol. 2020 May;214:108393. DM20KYR RU https://pubmed.ncbi.nlm.nih.gov/32222466 DMAYTIH DI DMAYTIH DMAYTIH DN S-06911 DMAYTIH MI TTK59TV DMAYTIH MN Vitamin D3 receptor (VDR) DMAYTIH MT DTT DMAYTIH MA Inhibitor DMAYTIH RN Evidence for tissue- and cell-type selective activation of the vitamin D receptor by Ro-26-9228, a noncalcemic analog of vitamin D3. J Cell Biochem. 2003 Feb 1;88(2):267-73. DMAYTIH RU https://pubmed.ncbi.nlm.nih.gov/12520525 DMXY34J DI DMXY34J DMXY34J DN S-110 DMXY34J MI TTHVCUP DMXY34J MN DNA [cytosine-5]-methyltransferase (DNMT) DMXY34J MT DTT DMXY34J MA Inhibitor DMXY34J RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMXY34J RU http://phrma-docs.phrma.org/sites/default/files/pdf/medicines-in-development-drug-list-rare-diseases.pdf DMXY34J DI DMXY34J DMXY34J DN S-110 DMXY34J MI TT6S2FE DMXY34J MN DNA [cytosine-5]-methyltransferase 1 (DNMT1) DMXY34J MT DTT DMXY34J MA Inhibitor DMXY34J RN S110, a 5-Aza-2'-deoxycytidine-containing dinucleotide, is an effective DNA methylation inhibitor in vivo and can reduce tumor growth. Mol Cancer Ther. 2010 May;9(5):1443-50. DMXY34J RU https://pubmed.ncbi.nlm.nih.gov/20442312 DM408GM DI DM408GM DM408GM DN S-474474 DM408GM MI TT8DBY3 DM408GM MN Angiotensin II receptor type-1 (AGTR1) DM408GM MT DTT DM408GM MA Blocker DM408GM RN Clinical pipeline report, company report or official report of Shionogi (2011). DM408GM RU http://www.shionogi.co.jp/index_e.html DM7F2VG DI DM7F2VG DM7F2VG DN SA-237 DM7F2VG MI TT0E5SK DM7F2VG MN Interleukin 6 receptor (IL6R) DM7F2VG MT DTT DM7F2VG MA Antagonist DM7F2VG RN IBC's 23rd Annual Antibody Engineering, 10th Annual Antibody Therapeutics International Conferences and the 2012 Annual Meeting of The Antibody Society: December 3-6, 2012, San Diego, CA. MAbs. 2013 March 1; 5(2): 178-201. DM7F2VG RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3893229/ DMGR98T DI DMGR98T DMGR98T DN SAGE-217 DMGR98T MI TTEX6LM DMGR98T MN GABA(A) receptor gamma-3 (GABRG3) DMGR98T MT DTT DMGR98T MA Modulator DMGR98T RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMGR98T RU http://phrma-docs.phrma.org/files/dmfile/MID_Mental-Illness-2017-Drug-List_Final.pdf DMI1R5S DI DMI1R5S DMI1R5S DN SAIT101 DMI1R5S MI TTUE541 DMI1R5S MN Leukocyte surface antigen Leu-16 (CD20) DMI1R5S MT DTT DMI1R5S RN Past, Present, and Future of Rituximab-The World's First Oncology Monoclonal Antibody Therapy. Front Oncol. 2018 Jun 4;8:163. DMI1R5S RU https://pubmed.ncbi.nlm.nih.gov/29915719 DMKHLRT DI DMKHLRT DMKHLRT DN SAND-26 DMKHLRT MI TTDIGC1 DMKHLRT MN Dipeptidyl peptidase 4 (DPP-4) DMKHLRT MT DTT DMKHLRT RN Clinical pipeline report, company report or official report of Siesonline. DMKHLRT RU http://www.siesonline.it/en/wp-content/uploads/2013/05/21.pdf DMXAO4J DI DMXAO4J DMXAO4J DN SAR153191 DMXAO4J MI TT0E5SK DMXAO4J MN Interleukin 6 receptor (IL6R) DMXAO4J MT DTT DMXAO4J MA Antagonist DMXAO4J RN Pharma & Vaccines. Product Development Pipeline. April 29 2009. DMXAO4J RU http://en.sanofi-aventis.com/binaries/RD_Phase_III_EN_tcm28-24007.pdf DMHFBOG DI DMHFBOG DMHFBOG DN SAR231893 DMHFBOG MI TTDWHC3 DMHFBOG MN Interleukin 4 receptor alpha (IL4R) DMHFBOG MT DTT DMHFBOG MA Modulator DMHFBOG RN Dupilumab in persistent asthma with elevated eosinophil levels. N Engl J Med. 2013 Jun 27;368(26):2455-66. DMHFBOG RU https://pubmed.ncbi.nlm.nih.gov/23688323 DMR0EWV DI DMR0EWV DMR0EWV DN SAR342434 DMR0EWV MI TTZOPHG DMR0EWV MN Insulin (INS) DMR0EWV MT DTT DMR0EWV MA Modulator DMR0EWV RN Biosimilar insulins: a European perspective. Diabetes Obes Metab. 2015 May; 17(5): 445-451. DMR0EWV RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4403967/ DMXGE3O DI DMXGE3O DMXGE3O DN SAR408701 DMXGE3O MI TTY6DTE DMXGE3O MN Carcinoembryonic antigen CEA (CD66e) DMXGE3O MT DTT DMXGE3O RN ClinicalTrials.gov (NCT02187848) Evaluation of SAR408701 in Patients With Advanced Solid Tumors. U.S. National Institutes of Health. DMXGE3O RU https://clinicaltrials.gov/ct2/show/NCT02187848 DMDMAE4 DI DMDMAE4 DMDMAE4 DN SAR438584 DMDMAE4 MI TT57ID8 DMDMAE4 MN Respiratory syncytial virus protein F (RSV F) DMDMAE4 MT DTT DMDMAE4 RN Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800040470) DMDMAE4 RU http://adisinsight.springer.com/drugs/800040470 DM8HCFD DI DM8HCFD DM8HCFD DN Sarilumab DM8HCFD MI TTDVAKP DM8HCFD MN HUMAN interleukin-6 receptor (IL6R) DM8HCFD MT DTT DM8HCFD MA Blocker DM8HCFD RN IL-6 as a keystone cytokine in health and disease. Nat Immunol. 2015 May;16(5):448-57. DM8HCFD RU https://pubmed.ncbi.nlm.nih.gov/25898198 DMUVSG4 DI DMUVSG4 DMUVSG4 DN Sasanlimab DMUVSG4 MI TTNBFWK DMUVSG4 MN Programmed cell death protein 1 (PD-1) DMUVSG4 MT DTT DMUVSG4 RN Pharmacologic Properties and Preclinical Activity of Sasanlimab, A High-affinity Engineered Anti-Human PD-1 Antibody. Mol Cancer Ther. 2020 Oct;19(10):2105-2116. DMUVSG4 RU https://pubmed.ncbi.nlm.nih.gov/32847983 DME5PN3 DI DME5PN3 DME5PN3 DN Satavaptan DME5PN3 MI TTK8R02 DME5PN3 MN Vasopressin V2 receptor (V2R) DME5PN3 MT DTT DME5PN3 MA Antagonist DME5PN3 RN Post-translational import of protein into the endoplasmic reticulum of a trypanosome: an in vitro system for discovery of anti-trypanosomal chemical entities. Biochem J. 2009 Apr 15;419(2):507-17. DME5PN3 RU https://pubmed.ncbi.nlm.nih.gov/19196237 DMALFKX DI DMALFKX DMALFKX DN Savolitinib DMALFKX MI TTNDSF4 DMALFKX MN Proto-oncogene c-Met (MET) DMALFKX MT DTT DMALFKX MA Inhibitor DMALFKX RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMALFKX RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DMAPRWV DI DMAPRWV DMAPRWV DN SaxaDapa FDC DMAPRWV MI TTDIGC1 DMAPRWV MN Dipeptidyl peptidase 4 (DPP-4) DMAPRWV MT DTT DMAPRWV MA Modulator DMAPRWV RN Saxagliptin: a new dipeptidyl peptidase-4 inhibitor for type 2 diabetes. Cardiol Rev. 2010 Jul-Aug;18(4):213-7. DMAPRWV RU https://pubmed.ncbi.nlm.nih.gov/20539105 DMAPRWV DI DMAPRWV DMAPRWV DN SaxaDapa FDC DMAPRWV MI TTN7Y4P DMAPRWV MN Sodium/glucose cotransporter 2 (SLC5A4) DMAPRWV MT DTT DMAPRWV MA Modulator DMAPRWV RN Saxagliptin: a new dipeptidyl peptidase-4 inhibitor for type 2 diabetes. Cardiol Rev. 2010 Jul-Aug;18(4):213-7. DMAPRWV RU https://pubmed.ncbi.nlm.nih.gov/20539105 DMME6GJ DI DMME6GJ DMME6GJ DN SB12 DMME6GJ MI TTKANGO DMME6GJ MN Complement C5 (CO5) DMME6GJ MT DTT DMME6GJ MA Inhibitor DMME6GJ RN Clinical promise of next-generation complement therapeutics. Nat Rev Drug Discov. 2019 Sep;18(9):707-729. DMME6GJ RU https://pubmed.ncbi.nlm.nih.gov/31324874 DM6L4ZT DI DM6L4ZT DM6L4ZT DN SB-742457 DM6L4ZT MI TTJS8PY DM6L4ZT MN 5-HT 6 receptor (HTR6) DM6L4ZT MT DTT DM6L4ZT MA Antagonist DM6L4ZT RN 5-HT6 receptors and Alzheimer's disease. Alzheimers Res Ther. 2013; 5(2): 15. DM6L4ZT RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3706851/ DM6XNJR DI DM6XNJR DM6XNJR DN SC-46553 DM6XNJR MI DEUO7V8 DM6XNJR MN Beta-glucosidase (bglA) DM6XNJR MT DME DM6XNJR MA Metabolism DM6XNJR RN Constitutive beta-glucosidases hydrolyzing ginsenoside Rb1 and Rb2 from human intestinal bacteria. Biol Pharm Bull. 2000 Dec;23(12):1481-5. DM6XNJR RU https://pubmed.ncbi.nlm.nih.gov/11145182 DM6XNJR DI DM6XNJR DM6XNJR DN SC-46553 DM6XNJR MI DE4LKZ9 DM6XNJR MN Beta-glucosidase (bglA) DM6XNJR MT DME DM6XNJR MA Metabolism DM6XNJR RN Constitutive beta-glucosidases hydrolyzing ginsenoside Rb1 and Rb2 from human intestinal bacteria. Biol Pharm Bull. 2000 Dec;23(12):1481-5. DM6XNJR RU https://pubmed.ncbi.nlm.nih.gov/11145182 DM6XNJR DI DM6XNJR DM6XNJR DN SC-46553 DM6XNJR MI DEM6GYO DM6XNJR MN Beta-glucosidase (bglA) DM6XNJR MT DME DM6XNJR MA Metabolism DM6XNJR RN nan DM6XNJR RU nan DM6XNJR DI DM6XNJR DM6XNJR DN SC-46553 DM6XNJR MI DE9N4OU DM6XNJR MN Beta-glucosidase (bglA) DM6XNJR MT DME DM6XNJR MA Metabolism DM6XNJR RN Characterization of the ginsenoside-transforming recombinant beta-glucosidase from Actinosynnema mirum and bioconversion of major ginsenosides into minor ginsenosides. Appl Microbiol Biotechnol. 2013 Jan;97(2):649-59. DM6XNJR RU https://pubmed.ncbi.nlm.nih.gov/22911093 DMK1IPV DI DMK1IPV DMK1IPV DN SCY-078 DMK1IPV MI TT0SFXH DMK1IPV MN Fungal 1,3-beta-glucan synthase (Fung GSC2) DMK1IPV MT DTT DMK1IPV MA Inhibitor DMK1IPV RN Pharmacodynamic target evaluation of a novel oral glucan synthase inhibitor, SCY-078 (MK-3118), using an in vivo murine invasive candidiasis model. Antimicrob Agents Chemother. 2015 Feb;59(2):1265-72. DMK1IPV RU https://pubmed.ncbi.nlm.nih.gov/25512406 DMAMTGI DI DMAMTGI DMAMTGI DN SD-101 DMAMTGI MI TTSHG0T DMAMTGI MN Toll-like receptor 9 (TLR9) DMAMTGI MT DTT DMAMTGI RN Novel drugs targeting Toll-like receptors for antiviral therapy. Future Virol. 2014 September; 9(9): 811-829. DMAMTGI RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4303062/ DM9DEYL DI DM9DEYL DM9DEYL DN SD-6010 DM9DEYL MI TTF10I9 DM9DEYL MN Nitric-oxide synthase inducible (NOS2) DM9DEYL MT DTT DM9DEYL MA Inhibitor DM9DEYL RN A 2-year randomised, double-blind, placebo-controlled, multicentre study of oral selective iNOS inhibitor, cindunistat (SD-6010), in patients with symptomatic osteoarthritis of the knee. Ann Rheum Dis. 2013 Feb;72(2):187-95. DM9DEYL RU https://pubmed.ncbi.nlm.nih.gov/23144445 DMBD4K3 DI DMBD4K3 DMBD4K3 DN Selinexor DMBD4K3 MI DE4LYSA DMBD4K3 MN Cytochrome P450 3A4 (CYP3A4) DMBD4K3 MT DME DMBD4K3 MA Metabolism DMBD4K3 RN FDA label of Selinexor. The 2020 official website of the U.S. Food and Drug Administration. DMBD4K3 RU https://www.accessdata.fda.gov/drugsatfda_docs/nda/2019/212306Orig1s000MultidisciplineR.pdf DMBD4K3 DI DMBD4K3 DMBD4K3 DN Selinexor DMBD4K3 MI TTCJUR4 DMBD4K3 MN Exportin-1 (XPO1) DMBD4K3 MT DTT DMBD4K3 MA Inhibitor DMBD4K3 RN Inhibition of CRM1-dependent nuclear export sensitizes malignant cells to cytotoxic and targeted agents. Semin Cancer Biol. 2014 August; 0: 62-73. DMBD4K3 RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4108511/ DMBD4K3 DI DMBD4K3 DMBD4K3 DN Selinexor DMBD4K3 MI DE4ZHS1 DMBD4K3 MN Glutathione S-transferase alpha-1 (GSTA1) DMBD4K3 MT DME DMBD4K3 MA Metabolism DMBD4K3 RN FDA label of Selinexor. The 2020 official website of the U.S. Food and Drug Administration. DMBD4K3 RU https://www.accessdata.fda.gov/drugsatfda_docs/nda/2019/212306Orig1s000MultidisciplineR.pdf DMBD4K3 DI DMBD4K3 DMBD4K3 DN Selinexor DMBD4K3 MI DEYGVN4 DMBD4K3 MN UDP-glucuronosyltransferase 1A1 (UGT1A1) DMBD4K3 MT DME DMBD4K3 MA Metabolism DMBD4K3 RN FDA label of Selinexor. The 2020 official website of the U.S. Food and Drug Administration. DMBD4K3 RU https://www.accessdata.fda.gov/drugsatfda_docs/nda/2019/212306Orig1s000MultidisciplineR.pdf DMC7W6R DI DMC7W6R DMC7W6R DN Selumetinib DMC7W6R MI TTIDAPM DMC7W6R MN ERK activator kinase 1 (MEK1) DMC7W6R MT DTT DMC7W6R MA Inhibitor DMC7W6R RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMC7W6R RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DMC7W6R DI DMC7W6R DMC7W6R DN Selumetinib DMC7W6R MI TTTW2NY DMC7W6R MN ERK activator kinase 2 (MEK2) DMC7W6R MT DTT DMC7W6R MA Inhibitor DMC7W6R RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMC7W6R RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DMC7W6R DI DMC7W6R DMC7W6R DN Selumetinib DMC7W6R MI TTROQ37 DMC7W6R MN MAPK/ERK kinase kinase (MAP3K) DMC7W6R MT DTT DMC7W6R MA Modulator DMC7W6R RN Intrinsic resistance to selumetinib, a selective inhibitor of MEK1/2, by cAMP-dependent protein kinase A activation in human lung and colorectal cancer cells.Br J Cancer.2012 May 8;106(10):1648-59. DMC7W6R RU https://www.ncbi.nlm.nih.gov/pubmed/22569000 DML83IW DI DML83IW DML83IW DN Semagacestat DML83IW MI DE4LYSA DML83IW MN Cytochrome P450 3A4 (CYP3A4) DML83IW MT DME DML83IW MA Metabolism DML83IW RN Disposition and metabolism of semagacestat, a {gamma}-secretase inhibitor, in humans. Drug Metab Dispos. 2010 Apr;38(4):554-65. DML83IW RU https://www.ncbi.nlm.nih.gov/pubmed/?term=20075192 DML83IW DI DML83IW DML83IW DN Semagacestat DML83IW MI DEIBDNY DML83IW MN Cytochrome P450 3A5 (CYP3A5) DML83IW MT DME DML83IW MA Metabolism DML83IW RN Disposition and metabolism of semagacestat, a {gamma}-secretase inhibitor, in humans. Drug Metab Dispos. 2010 Apr;38(4):554-65. DML83IW RU https://www.ncbi.nlm.nih.gov/pubmed/?term=20075192 DML83IW DI DML83IW DML83IW DN Semagacestat DML83IW MI TT9W8GU DML83IW MN Gamma-secretase (GS) DML83IW MT DTT DML83IW MA Modulator DML83IW RN A phase 3 trial of semagacestat for treatment of Alzheimer's disease. N Engl J Med. 2013 Jul 25;369(4):341-50. DML83IW RU https://pubmed.ncbi.nlm.nih.gov/23883379 DMKL9QO DI DMKL9QO DMKL9QO DN Seocalcitol DMKL9QO MI TTK59TV DMKL9QO MN Vitamin D3 receptor (VDR) DMKL9QO MT DTT DMKL9QO MA Inhibitor DMKL9QO RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMKL9QO RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMG2QP4 DI DMG2QP4 DMG2QP4 DN SEP-363856 DMG2QP4 MI TTSQIFT DMG2QP4 MN 5-HT 1A receptor (HTR1A) DMG2QP4 MT DTT DMG2QP4 MA Agonist DMG2QP4 RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMG2QP4 RU http://phrma-docs.phrma.org/files/dmfile/MID_Neurological-Disorders-Drug-List_2018.pdf DMG2QP4 DI DMG2QP4 DMG2QP4 DN SEP-363856 DMG2QP4 MI TTIU98M DMG2QP4 MN Trace amine-associated receptor-1 (TAAR1) DMG2QP4 MT DTT DMG2QP4 MA Agonist DMG2QP4 RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMG2QP4 RU http://phrma-docs.phrma.org/files/dmfile/MID_Neurological-Disorders-Drug-List_2018.pdf DM5VH6U DI DM5VH6U DM5VH6U DN Serlopitant DM5VH6U MI TTZPO1L DM5VH6U MN Substance-P receptor (TACR1) DM5VH6U MT DTT DM5VH6U MA Antagonist DM5VH6U RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DM5VH6U RU http://phrma-docs.phrma.org/files/dmfile/MID_Skin_Diseases_2018_9_FINAL.pdf DMZ61IA DI DMZ61IA DMZ61IA DN Setipiprant DMZ61IA MI TTNVEIR DMZ61IA MN Prostaglandin D2 receptor (PTGDR) DMZ61IA MT DTT DMZ61IA MA Antagonist DMZ61IA RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMZ61IA RU http://phrma-docs.phrma.org/files/dmfile/MID_Skin_Diseases_2018_9_FINAL.pdf DMZ61IA DI DMZ61IA DMZ61IA DN Setipiprant DMZ61IA MI TTQDMX5 DMZ61IA MN Prostaglandin D2 receptor 2 (PTGDR2) DMZ61IA MT DTT DMZ61IA MA Antagonist DMZ61IA RN Setipiprant, a selective CRTH2 antagonist, reduces allergen-induced airway responses in allergic asthmatics. Clin Exp Allergy. 2014 Aug;44(8):1044-52. DMZ61IA RU https://pubmed.ncbi.nlm.nih.gov/24964348 DM1NQDW DI DM1NQDW DM1NQDW DN SGI110 DM1NQDW MI TT6S2FE DM1NQDW MN DNA [cytosine-5]-methyltransferase 1 (DNMT1) DM1NQDW MT DTT DM1NQDW MA Modulator DM1NQDW RN Immunomodulatory action of the DNA methyltransferase inhibitor SGI-110 in epithelial ovarian cancer cells and xenografts. Epigenetics. 2015;10(3):237-46. DM1NQDW RU https://pubmed.ncbi.nlm.nih.gov/25793777 DM4N1SP DI DM4N1SP DM4N1SP DN Shigamabs DM4N1SP MI TT1HYOF DM4N1SP MN Bacterial Shiga toxin 2 subunit B (Bact stxII) DM4N1SP MT DTT DM4N1SP MA Modulator DM4N1SP RN Antibacterial antibodies gain traction. Nat Rev Drug Discov. 2015 Nov;14(11):737-8. DM4N1SP RU https://www.ncbi.nlm.nih.gov/pubmed/26514853 DMEWRXA DI DMEWRXA DMEWRXA DN SHP647 DMEWRXA MI TTBD6I7 DMEWRXA MN Mucosal addressin cell adhesion molecule 1 (MADCAM1) DMEWRXA MT DTT DMEWRXA MA Inhibitor DMEWRXA RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMEWRXA RU http://phrma-docs.phrma.org/files/dmfile/medicines-in-development-drug-list-autoimmune-diseases.pdf DMMIWCE DI DMMIWCE DMMIWCE DN Sifuvirtide DMMIWCE MI TTG90S6 DMMIWCE MN Human immunodeficiency virus Glycoprotein 41 (HIV gp41) DMMIWCE MT DTT DMMIWCE MA Modulator DMMIWCE RN Broad antiviral activity and crystal structure of HIV-1 fusion inhibitor sifuvirtide.J Biol Chem.2012 Feb 24;287(9):6788-96. DMMIWCE RU https://www.ncbi.nlm.nih.gov/pubmed/22228771 DM4YDAJ DI DM4YDAJ DM4YDAJ DN Sildenafil DM4YDAJ MI TTRYFSB DM4YDAJ MN HUMAN phosphodiesterase type 5 (PDE5) DM4YDAJ MT DTT DM4YDAJ MA Inhibitor DM4YDAJ RN Nitric oxide inhibits the replication cycle of severe acute respiratory syndrome coronavirus. J Virol. 2005 Feb;79(3):1966-9. doi: 10.1128/JVI.79.3.1966-1969.2005. DM4YDAJ RU https://pubmed.ncbi.nlm.nih.gov/15650225 DMVO7UW DI DMVO7UW DMVO7UW DN Siltuximab DMVO7UW MI TTJH4Y5 DMVO7UW MN HUMAN interleukin 6 (IL6) DMVO7UW MT DTT DMVO7UW MA Inhibitor DMVO7UW RN Siltuximab. In: Drugs and Lactation Database (LactMed) [Internet]. Bethesda (MD): National Library of Medicine (US); 2006. 2018 Dec 3. DMVO7UW RU https://pubmed.ncbi.nlm.nih.gov/29999789 DM18QHT DI DM18QHT DM18QHT DN Simvastatin acid DM18QHT MI DTUGYRD DM18QHT MN P-glycoprotein 1 (ABCB1) DM18QHT MT DTP DM18QHT MA Substrate DM18QHT RN Interactions of human P-glycoprotein with simvastatin, simvastatin acid, and atorvastatin. Pharm Res. 2004 Sep;21(9):1686-91. DM18QHT RU https://doi.org/10.1023/B:PHAM.0000041466.84653.8c DMK8AQP DI DMK8AQP DMK8AQP DN Sirukumab DMK8AQP MI TT0E5SK DMK8AQP MN Interleukin 6 receptor (IL6R) DMK8AQP MT DTT DMK8AQP RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2310). DMK8AQP RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2310 DMK8AQP DI DMK8AQP DMK8AQP DN Sirukumab DMK8AQP MI TTT1V78 DMK8AQP MN Interleukin-6 (IL6) DMK8AQP MT DTT DMK8AQP MA Inhibitor DMK8AQP RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMK8AQP RU http://phrma-docs.phrma.org/files/dmfile/medicines-in-development-drug-list-autoimmune-diseases.pdf DM6BZCV DI DM6BZCV DM6BZCV DN Sivelestat DM6BZCV MI TTPLTSQ DM6BZCV MN Neutrophil elastase (NE) DM6BZCV MT DTT DM6BZCV MA Inhibitor DM6BZCV RN Neutrophil elastase inhibitor (sivelestat) reduces the levels of inflammatory mediators by inhibiting NF-kB. Inflamm Res. 2009 Apr;58(4):198-203. DM6BZCV RU https://pubmed.ncbi.nlm.nih.gov/19169649 DM6BZCV DI DM6BZCV DM6BZCV DN Sivelestat DM6BZCV MI TT3NKIB DM6BZCV MN Pancreatic elastase 1 (CELA1) DM6BZCV MT DTT DM6BZCV MA Inhibitor DM6BZCV RN Sivelestat (selective neutrophil elastase inhibitor) improves the mortality rate of sepsis associated with both acute respiratory distress syndrome... Shock. 2010 Jan;33(1):14-8. DM6BZCV RU https://pubmed.ncbi.nlm.nih.gov/19487982 DMWOF1E DI DMWOF1E DMWOF1E DN SKY59 DMWOF1E MI TTKANGO DMWOF1E MN Complement C5 (CO5) DMWOF1E MT DTT DMWOF1E MA Inhibitor DMWOF1E RN The complement C5 inhibitor crovalimab in paroxysmal nocturnal hemoglobinuria. Blood. 2020 Mar 19;135(12):912-920. DMWOF1E RU https://pubmed.ncbi.nlm.nih.gov/31978221 DMH7W9X DI DMH7W9X DMH7W9X DN SNDX-275 DMH7W9X MI TTBH0VX DMH7W9X MN Histone deacetylase (HDAC) DMH7W9X MT DTT DMH7W9X MA Inhibitor DMH7W9X RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMH7W9X RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DMH7W9X DI DMH7W9X DMH7W9X DN SNDX-275 DMH7W9X MI TT6R7JZ DMH7W9X MN Histone deacetylase 1 (HDAC1) DMH7W9X MT DTT DMH7W9X MA Inhibitor DMH7W9X RN Emerging therapies for multiple myeloma. Expert Opin Emerg Drugs. 2009 Mar;14(1):99-127. DMH7W9X RU https://pubmed.ncbi.nlm.nih.gov/19249983 DMOQKAD DI DMOQKAD DMOQKAD DN SNF472 DMOQKAD MI TTGUHMF DMOQKAD MN Hydroxyapatite (HA) DMOQKAD MT DTT DMOQKAD MA Binder DMOQKAD RN Clinical pipeline report, company report or official report of Sanifit. DMOQKAD RU https://www.sanifit.com/lead-compound-snf472/ DMZE2JO DI DMZE2JO DMZE2JO DN SNS-595 DMZE2JO MI TT0IHXV DMZE2JO MN DNA topoisomerase II (TOP2) DMZE2JO MT DTT DMZE2JO MA Modulator DMZE2JO RN A phase 1b/2 study of vosaroxin in combination with cytarabine in patients with relapsed or refractory acute myeloid leukemia.Haematologica.2015 Feb;100(2):231-7. DMZE2JO RU https://www.ncbi.nlm.nih.gov/pubmed/25381131 DMPBA0D DI DMPBA0D DMPBA0D DN Sofpironium bromide DMPBA0D MI TTUPDWN DMPBA0D MN Cholinergic receptor unspecific (CHR) DMPBA0D MT DTT DMPBA0D MA Antagonist DMPBA0D RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMPBA0D RU http://phrma-docs.phrma.org/files/dmfile/MID_Skin_Diseases_2018_9_FINAL.pdf DM0HIU5 DI DM0HIU5 DM0HIU5 DN Solanezumab DM0HIU5 MI TTE4KHA DM0HIU5 MN Amyloid beta A4 protein (APP) DM0HIU5 MT DTT DM0HIU5 MA Modulator DM0HIU5 RN Phase 3 trials of solanezumab for mild-to-moderate Alzheimer's disease. N Engl J Med. 2014 Jan 23;370(4):311-21. DM0HIU5 RU https://pubmed.ncbi.nlm.nih.gov/24450890 DM6QZIA DI DM6QZIA DM6QZIA DN Solithromycin DM6QZIA MI TTUWYEA DM6QZIA MN Bacterial 50S ribosomal RNA (Bact 50S rRNA) DM6QZIA MT DTT DM6QZIA MA Modulator DM6QZIA RN Company report (cempra) DM6QZIA RU http://www.cempra.com/products/Solithromycin-cem-101/ DMLAYTP DI DMLAYTP DMLAYTP DN Soluble ferric pyrophosphate DMLAYTP MI TTUDR0C DMLAYTP MN Iron (Fe) DMLAYTP MT DTT DMLAYTP MA Modulator DMLAYTP RN A micronised, dispersible ferric pyrophosphate with high relative bioavailability in man. Br J Nutr. 2004 Jan;91(1):107-12. DMLAYTP RU https://pubmed.ncbi.nlm.nih.gov/14748943 DMIG4OX DI DMIG4OX DMIG4OX DN SOTB07 DMIG4OX MI TTZ97H5 DMIG4OX MN Phosphodiesterase 4A (PDE4A) DMIG4OX MT DTT DMIG4OX MA Inhibitor DMIG4OX RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1300). DMIG4OX RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1300 DMIG4OX DI DMIG4OX DMIG4OX DN SOTB07 DMIG4OX MI TTVIAT9 DMIG4OX MN Phosphodiesterase 4B (PDE4B) DMIG4OX MT DTT DMIG4OX MA Inhibitor DMIG4OX RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1301). DMIG4OX RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1301 DMIG4OX DI DMIG4OX DMIG4OX DN SOTB07 DMIG4OX MI TTSKMI8 DMIG4OX MN Phosphodiesterase 4D (PDE4D) DMIG4OX MT DTT DMIG4OX MA Inhibitor DMIG4OX RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1303). DMIG4OX RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1303 DMLSV74 DI DMLSV74 DMLSV74 DN Sotorasib DMLSV74 MI TT3LH46 DMLSV74 MN KRAS G12C mutant (KRAS G12C) DMLSV74 MT DTT DMLSV74 MA Inhibitor DMLSV74 RN Clinical pipeline report, company report or official report of Amgen. DMLSV74 RU https://www.amgenpipeline.com/ DMMP51W DI DMMP51W DMMP51W DN sparsentan DMMP51W MI TT8DBY3 DMMP51W MN Angiotensin II receptor type-1 (AGTR1) DMMP51W MT DTT DMMP51W MA Antagonist DMMP51W RN Designed multiple ligands. An emerging drug discovery paradigm. J Med Chem. 2005 Oct 20;48(21):6523-43. DMMP51W RU https://pubmed.ncbi.nlm.nih.gov/16220969 DMMP51W DI DMMP51W DMMP51W DN sparsentan DMMP51W MI TTKRD0G DMMP51W MN Endothelin A receptor (EDNRA) DMMP51W MT DTT DMMP51W MA Antagonist DMMP51W RN Designed multiple ligands. An emerging drug discovery paradigm. J Med Chem. 2005 Oct 20;48(21):6523-43. DMMP51W RU https://pubmed.ncbi.nlm.nih.gov/16220969 DM4TOEQ DI DM4TOEQ DM4TOEQ DN Spartalizumab DM4TOEQ MI TTNBFWK DM4TOEQ MN Programmed cell death protein 1 (PD-1) DM4TOEQ MT DTT DM4TOEQ RN Development of Inhibitors of the Programmed Cell Death-1/Programmed Cell Death-Ligand 1 Signaling Pathway.J Med Chem. 2019 Feb 28;62(4):1715-1730. DM4TOEQ RU https://pubmed.ncbi.nlm.nih.gov/30247903 DM7NV1I DI DM7NV1I DM7NV1I DN SPD-465 DM7NV1I MI TTIU98M DM7NV1I MN Trace amine-associated receptor-1 (TAAR1) DM7NV1I MT DTT DM7NV1I MA Agonist DM7NV1I RN Methamphetamine and HIV-1-induced neurotoxicity: role of trace amine associated receptor 1 cAMP signaling in astrocytes. Neuropharmacology. 2014 Oct;85:499-507. DM7NV1I RU https://pubmed.ncbi.nlm.nih.gov/24950453 DMVJNFI DI DMVJNFI DMVJNFI DN Spermidine DMVJNFI MI TTR7UJ3 DMVJNFI MN Cytoplasmic thioredoxin reductase (TXNRD1) DMVJNFI MT DTT DMVJNFI MA Inhibitor DMVJNFI RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMVJNFI RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMVJNFI DI DMVJNFI DMVJNFI DN Spermidine DMVJNFI MI DTOFXP5 DMVJNFI MN MFS-type transporter SLC18B1 (SLC18B1) DMVJNFI MT DTP DMVJNFI MA Substrate DMVJNFI RN Identification of a mammalian vesicular polyamine transporter. Sci Rep. 2014 Oct 30;4:6836. DMVJNFI RU http://www.ncbi.nlm.nih.gov/pubmed/25355561 DMVJNFI DI DMVJNFI DMVJNFI DN Spermidine DMVJNFI MI DTT79CX DMVJNFI MN Organic cation transporter 1 (SLC22A1) DMVJNFI MT DTP DMVJNFI MA Substrate DMVJNFI RN Human intestinal transporter database: QSAR modeling and virtual profiling of drug uptake, efflux and interactions. Pharm Res. 2013 Apr;30(4):996-1007. DMVJNFI RU https://doi.org/10.1007/s11095-012-0935-x DMVJNFI DI DMVJNFI DMVJNFI DN Spermidine DMVJNFI MI DEMWO83 DMVJNFI MN Putrescine acetyltransferase (SSAT1) DMVJNFI MT DME DMVJNFI MA Metabolism DMVJNFI RN The use of novel C-methylated spermidine derivatives to investigate the regulation of polyamine metabolism. J Med Chem. 2011 Jul 14;54(13):4611-8. DMVJNFI RU https://www.ncbi.nlm.nih.gov/pubmed/?term=21639123 DMACVEI DI DMACVEI DMACVEI DN SPI-2012 DMACVEI MI TT5TQ2W DMACVEI MN Granulocyte colony-stimulating factor (CSF3) DMACVEI MT DTT DMACVEI MA Modulator DMACVEI RN Company report (Sppirx) DMACVEI RU http://www.sppirx.com/338-spectrum-products-development-spi2012.html DM3PS2E DI DM3PS2E DM3PS2E DN Squalamine DM3PS2E MI TTGKIED DM3PS2E MN Fibroblast growth factor-2 (FGF2) DM3PS2E MT DTT DM3PS2E MA Modulator DM3PS2E RN Clinical pipeline report, company report or official report of Ohr Pharmaceutical. DM3PS2E RU http://www.ohrpharmaceutical.com/research/squalamine DM3PS2E DI DM3PS2E DM3PS2E DN Squalamine DM3PS2E MI TTSM78N DM3PS2E MN Platelet-derived growth factor A (PDGFA) DM3PS2E MT DTT DM3PS2E MA Inhibitor DM3PS2E RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DM3PS2E RU http://phrma-docs.phrma.org/files/dmfile/mid-diabetes-drug-list.pdf DM3PS2E DI DM3PS2E DM3PS2E DN Squalamine DM3PS2E MI TT9HKJA DM3PS2E MN Vascular endothelial growth factor (VEGF) DM3PS2E MT DTT DM3PS2E MA Modulator DM3PS2E RN Clinical pipeline report, company report or official report of Ohr Pharmaceutical. DM3PS2E RU http://www.ohrpharmaceutical.com/research/squalamine DM1ODMR DI DM1ODMR DM1ODMR DN SR46349B DM1ODMR MI TTJQOD7 DM1ODMR MN 5-HT 2A receptor (HTR2A) DM1ODMR MT DTT DM1ODMR MA Modulator DM1ODMR RN SR46349-B, a 5-HT(2A/2C) receptor antagonist, potentiates haloperidol-induced dopamine release in rat medial prefrontal cortex and nucleus accumbens. Neuropsychopharmacology. 2002 Sep;27(3):430-41. DM1ODMR RU https://www.ncbi.nlm.nih.gov/pubmed/12225700 DM1ODMR DI DM1ODMR DM1ODMR DN SR46349B DM1ODMR MI TTWJBZ5 DM1ODMR MN 5-HT 2C receptor (HTR2C) DM1ODMR MT DTT DM1ODMR MA Modulator DM1ODMR RN SR46349-B, a 5-HT(2A/2C) receptor antagonist, potentiates haloperidol-induced dopamine release in rat medial prefrontal cortex and nucleus accumbens. Neuropsychopharmacology. 2002 Sep;27(3):430-41. DM1ODMR RU https://www.ncbi.nlm.nih.gov/pubmed/12225700 DMT71EX DI DMT71EX DMT71EX DN SSR-126517E DMT71EX MI TTCIHJA DMT71EX MN Coagulation factor Xa (F10) DMT71EX MT DTT DMT71EX MA Inhibitor DMT71EX RN Semuloparin for the prevention of venous thromboembolic events in cancer patients. Drugs Today (Barc). 2012 Jul;48(7):451-7. DMT71EX RU https://pubmed.ncbi.nlm.nih.gov/22844656 DMVLKDX DI DMVLKDX DMVLKDX DN Streptokinase rectal suppository DMVLKDX MI TT2VCLI DMVLKDX MN Streptococcus Streptokinase (Stre-coc skc) DMVLKDX MT DTT DMVLKDX MA Modulator DMVLKDX RN Pharmacovigilance program to monitor adverse reactions of recombinant streptokinase in acute myocardial infarction. BMC Clin Pharmacol. 2005 Nov 2;5:5. DMVLKDX RU https://www.ncbi.nlm.nih.gov/pubmed/16262910 DMPOTM4 DI DMPOTM4 DMPOTM4 DN Sulfatinib DMPOTM4 MI TTRLW2X DMPOTM4 MN Fibroblast growth factor receptor 1 (FGFR1) DMPOTM4 MT DTT DMPOTM4 MA Inhibitor DMPOTM4 RN Clinical pipeline report, company report or official report of Hutchison Medi Pharma. DMPOTM4 RU http://www.hmplglobal.com/en/sulfatinib/ DMPOTM4 DI DMPOTM4 DMPOTM4 DN Sulfatinib DMPOTM4 MI TT7MRDV DMPOTM4 MN Macrophage colony-stimulating factor 1 receptor (CSF1R) DMPOTM4 MT DTT DMPOTM4 MA Inhibitor DMPOTM4 RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMPOTM4 RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DMPOTM4 DI DMPOTM4 DMPOTM4 DN Sulfatinib DMPOTM4 MI TTVJ1D8 DMPOTM4 MN Vascular endothelial growth factor receptor (VEGFR) DMPOTM4 MT DTT DMPOTM4 MA Inhibitor DMPOTM4 RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMPOTM4 RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DMPOTM4 DI DMPOTM4 DMPOTM4 DN Sulfatinib DMPOTM4 MI TT2Q6G1 DMPOTM4 MN Vascular endothelial growth factor receptor 1 (FLT-1) DMPOTM4 MT DTT DMPOTM4 MA Inhibitor DMPOTM4 RN Clinical pipeline report, company report or official report of Hutchison Medi Pharma. DMPOTM4 RU http://www.hmplglobal.com/en/sulfatinib/ DMPOTM4 DI DMPOTM4 DMPOTM4 DN Sulfatinib DMPOTM4 MI TTUTJGQ DMPOTM4 MN Vascular endothelial growth factor receptor 2 (KDR) DMPOTM4 MT DTT DMPOTM4 MA Inhibitor DMPOTM4 RN Clinical pipeline report, company report or official report of Hutchison Medi Pharma. DMPOTM4 RU http://www.hmplglobal.com/en/sulfatinib/ DMPOTM4 DI DMPOTM4 DMPOTM4 DN Sulfatinib DMPOTM4 MI TTDCBX5 DMPOTM4 MN Vascular endothelial growth factor receptor 3 (FLT-4) DMPOTM4 MT DTT DMPOTM4 MA Inhibitor DMPOTM4 RN Clinical pipeline report, company report or official report of Hutchison Medi Pharma. DMPOTM4 RU http://www.hmplglobal.com/en/sulfatinib/ DMMD856 DI DMMD856 DMMD856 DN Sulopenem DMMD856 MI TTJP4SM DMMD856 MN Bacterial Penicillin binding protein (Bact PBP) DMMD856 MT DTT DMMD856 MA Modulator DMMD856 RN In vitro antibacterial activity of a new parenteral penem, sulopenem. Jpn J Antibiot. 1996 Apr;49(4):324-37. DMMD856 RU https://pubmed.ncbi.nlm.nih.gov/8786624 DM07653 DI DM07653 DM07653 DN SULTHIAME DM07653 MI TTANPDJ DM07653 MN Carbonic anhydrase II (CA-II) DM07653 MT DTT DM07653 MA Inhibitor DM07653 RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DM07653 RU https://pubmed.ncbi.nlm.nih.gov/10592235 DMYHV17 DI DMYHV17 DMYHV17 DN Sumanirole DMYHV17 MI DEJGDUW DMYHV17 MN Cytochrome P450 1A2 (CYP1A2) DMYHV17 MT DME DMYHV17 MA Metabolism DMYHV17 RN Psychological effects of dopamine agonist treatment in patients with hyperprolactinemia and prolactin-secreting adenomas. Eur J Endocrinol. 2019 Jan 1;180(1):31-40. DMYHV17 RU http://www.ncbi.nlm.nih.gov/pubmed/30400048 DMYHV17 DI DMYHV17 DMYHV17 DN Sumanirole DMYHV17 MI TTEX248 DMYHV17 MN Dopamine D2 receptor (D2R) DMYHV17 MT DTT DMYHV17 MA Agonist DMYHV17 RN Drugs used to treat Parkinson's disease, present status and future directions. CNS Neurol Disord Drug Targets. 2008 Oct;7(4):321-42. DMYHV17 RU https://pubmed.ncbi.nlm.nih.gov/18991661 DMXNZQK DI DMXNZQK DMXNZQK DN SUN-101 DMXNZQK MI TTOXS3C DMXNZQK MN Muscarinic acetylcholine receptor (CHRM) DMXNZQK MT DTT DMXNZQK MA Inhibitor DMXNZQK RN Long-acting bronchodilators in COPD: Where are we now and where are we going Breathe 06/2014; 10(2):110-120. DMXNZQK RU http://breathe.ersjournals.com/content/10/2/110 DMH2FN1 DI DMH2FN1 DMH2FN1 DN Suronacrine maleate DMH2FN1 MI TT1RS9F DMH2FN1 MN Acetylcholinesterase (AChE) DMH2FN1 MT DTT DMH2FN1 MA Modulator DMH2FN1 RN Potential clinical use of an adrenergic/cholinergic agent (HP 128) in the treatment of Alzheimer's disease. Ann N Y Acad Sci. 1991;640:263-7. DMH2FN1 RU https://www.ncbi.nlm.nih.gov/pubmed/1776748 DMH2FN1 DI DMH2FN1 DMH2FN1 DN Suronacrine maleate DMH2FN1 MI TTAWNKZ DMH2FN1 MN Norepinephrine transporter (NET) DMH2FN1 MT DTT DMH2FN1 MA Modulator DMH2FN1 RN Potential clinical use of an adrenergic/cholinergic agent (HP 128) in the treatment of Alzheimer's disease. Ann N Y Acad Sci. 1991;640:263-7. DMH2FN1 RU https://www.ncbi.nlm.nih.gov/pubmed/1776748 DMY7WH1 DI DMY7WH1 DMY7WH1 DN Sutimlimab DMY7WH1 MI TT7LRQH DMY7WH1 MN Complement C1s component (C1S) DMY7WH1 MT DTT DMY7WH1 MA Inhibitor DMY7WH1 RN Antibodies to watch in 2020. MAbs. Jan-Dec 2020;12(1):1703531. DMY7WH1 RU https://pubmed.ncbi.nlm.nih.gov/31847708 DM3BO8G DI DM3BO8G DM3BO8G DN SUVN-G3031 DM3BO8G MI TT9JNIC DM3BO8G MN Histamine H3 receptor (H3R) DM3BO8G MT DTT DM3BO8G MA Antagonist DM3BO8G RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DM3BO8G RU http://phrma-docs.phrma.org/files/dmfile/MID_Neurological-Disorders-Drug-List_2018.pdf DMOVEDH DI DMOVEDH DMOVEDH DN SYM-004 DMOVEDH MI TTGKNB4 DMOVEDH MN Epidermal growth factor receptor (EGFR) DMOVEDH MT DTT DMOVEDH RN Sym004, a novel EGFR antibody mixture, can overcome acquired resistance to cetuximab. Neoplasia. 2013 Oct;15(10):1196-206. DMOVEDH RU https://pubmed.ncbi.nlm.nih.gov/24204198 DMRUEKC DI DMRUEKC DMRUEKC DN Synthetic conjugated estrogen DMRUEKC MI TTZAYWL DMRUEKC MN Estrogen receptor (ESR) DMRUEKC MT DTT DMRUEKC MA Modulator DMRUEKC RN Relief of hot flushes with new plant-derived 10-component synthetic conjugated estrogens. Obstet Gynecol. 2004 Feb;103(2):245-53. DMRUEKC RU https://pubmed.ncbi.nlm.nih.gov/14754691 DMXU4ON DI DMXU4ON DMXU4ON DN Synthetic hypericin DMXU4ON MI DTI7UX6 DMXU4ON MN Breast cancer resistance protein (ABCG2) DMXU4ON MT DTP DMXU4ON MA Substrate DMXU4ON RN Drug efflux transporters, MRP1 and BCRP, affect the outcome of hypericin-mediated photodynamic therapy in HT-29 adenocarcinoma cells. Photochem Photobiol Sci. 2009 Dec;8(12):1716-23. DMXU4ON RU https://doi.org/10.1039/b9pp00086k DMXU4ON DI DMXU4ON DMXU4ON DN Synthetic hypericin DMXU4ON MI TTYVX59 DMXU4ON MN Protein kinase C (PRKC) DMXU4ON MT DTT DMXU4ON MA Inhibitor DMXU4ON RN Characterization of the interaction of hypericin with protein kinase C in U-87 MG human glioma cells. Photochem Photobiol. 2006 May-Jun;82(3):720-8. DMXU4ON RU https://pubmed.ncbi.nlm.nih.gov/16396605 DM9L1AC DI DM9L1AC DM9L1AC DN SYR-472 DM9L1AC MI TTDIGC1 DM9L1AC MN Dipeptidyl peptidase 4 (DPP-4) DM9L1AC MT DTT DM9L1AC MA Inhibitor DM9L1AC RN SYR-472, a novel once-weekly dipeptidyl peptidase-4 (DPP-4) inhibitor, in type 2 diabetes mellitus: a phase 2, randomised, double-blind, placebo-controlled trial. Lancet Diabetes Endocrinol. 2014 Feb;2(2):125-32. DM9L1AC RU https://pubmed.ncbi.nlm.nih.gov/24622716 DMR32KN DI DMR32KN DMR32KN DN TA-6366 DMR32KN MI DEB30C5 DMR32KN MN Carboxylesterase 1 (CES1) DMR32KN MT DME DMR32KN MA Metabolism DMR32KN RN Inhibition of human liver carboxylesterase (hCE1) by organophosphate ester flame retardants and plasticizers: implications for pharmacotherapy. Toxicol Sci. 2019 Jul 3. pii: kfz149. DMR32KN RU https://www.ncbi.nlm.nih.gov/pubmed/?term=31268531 DMKSAG1 DI DMKSAG1 DMKSAG1 DN Tabalumab DMKSAG1 MI TTWMIDN DMKSAG1 MN B-cell-activating factor (TNFSF13B) DMKSAG1 MT DTT DMKSAG1 MA Modulator DMKSAG1 RN Tabalumab, an anti-BAFF monoclonal antibody, in patients with active rheumatoid arthritis with an inadequate response to TNF inhibitors. Ann Rheum Dis. 2013 Sep 1;72(9):1461-8. DMKSAG1 RU https://pubmed.ncbi.nlm.nih.gov/23268367 DMW5PHL DI DMW5PHL DMW5PHL DN Taberminogene vadenovec DMW5PHL MI TTDCBX5 DMW5PHL MN Vascular endothelial growth factor receptor 3 (FLT-4) DMW5PHL MT DTT DMW5PHL MA Modulator DMW5PHL RN Advances in kinase targeting: current clinical use and clinical trials. Trends Pharmacol Sci. 2014 Nov;35(11):604-20. DMW5PHL RU https://pubmed.ncbi.nlm.nih.gov/25312588 DM1NTVQ DI DM1NTVQ DM1NTVQ DN Tadekinig alfa DM1NTVQ MI TTRICUF DM1NTVQ MN Interleukin-18 (IL18) DM1NTVQ MT DTT DM1NTVQ MA Inhibitor DM1NTVQ RN Clinical pipeline report, company report or official report of AB2 Bio. DM1NTVQ RU http://www.ab2bio.com/en/products.36.html DMCF6SX DI DMCF6SX DMCF6SX DN TAK-491 DMCF6SX MI TT8DBY3 DMCF6SX MN Angiotensin II receptor type-1 (AGTR1) DMCF6SX MT DTT DMCF6SX MA Modulator DMCF6SX RN 2011 FDA drug approvals. Nat Rev Drug Discov. 2012 Feb 1;11(2):91-4. DMCF6SX RU https://pubmed.ncbi.nlm.nih.gov/22293555 DM2H8FZ DI DM2H8FZ DM2H8FZ DN TAK-700 DM2H8FZ MI TTRA5BZ DM2H8FZ MN Steroid 17-alpha-monooxygenase (S17AH) DM2H8FZ MT DTT DM2H8FZ MA Modulator DM2H8FZ RN Orteronel (TAK-700), a novel non-steroidal 17,20-lyase inhibitor: effects on steroid synthesis in human and monkey adrenal cells and serum steroid levels in cynomolgus monkeys. J Steroid Biochem Mol Biol. 2012 Apr;129(3-5):115-28. DM2H8FZ RU https://pubmed.ncbi.nlm.nih.gov/22249003 DMIM5AP DI DMIM5AP DMIM5AP DN TAK-875 DMIM5AP MI DE4LYSA DMIM5AP MN Cytochrome P450 3A4 (CYP3A4) DMIM5AP MT DME DMIM5AP MA Metabolism DMIM5AP RN Disposition and metabolism of the G protein-coupled receptor 40 agonist TAK-875 (fasiglifam) in rats, dogs, and humans. Xenobiotica. 2019 Apr;49(4):433-445. DMIM5AP RU https://www.ncbi.nlm.nih.gov/pubmed/?term=29557709 DMIM5AP DI DMIM5AP DMIM5AP DN TAK-875 DMIM5AP MI DEIBDNY DMIM5AP MN Cytochrome P450 3A5 (CYP3A5) DMIM5AP MT DME DMIM5AP MA Metabolism DMIM5AP RN Disposition and metabolism of the G protein-coupled receptor 40 agonist TAK-875 (fasiglifam) in rats, dogs, and humans. Xenobiotica. 2019 Apr;49(4):433-445. DMIM5AP RU https://www.ncbi.nlm.nih.gov/pubmed/?term=29557709 DMIM5AP DI DMIM5AP DMIM5AP DN TAK-875 DMIM5AP MI TTB8FUC DMIM5AP MN Free fatty acid receptor 1 (GPR40) DMIM5AP MT DTT DMIM5AP MA Modulator DMIM5AP RN Efficacy and safety of fasiglifam (TAK-875), a G protein-coupled receptor 40 agonist, in Japanese patients with type 2 diabetes inadequately controlled by diet and exercise: a randomized, double-blind, placebo-controlled, phase III trial. Diabetes Obes Metab. 2015 Jul;17(7):675-81. 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DMVSX6O RU https://pubmed.ncbi.nlm.nih.gov/16083333 DMTCR2O DI DMTCR2O DMTCR2O DN Tecarfarin DMTCR2O MI TTEUC8H DMTCR2O MN Vitamin K epoxide reductase complex 1 (VKORC1) DMTCR2O MT DTT DMTCR2O MA Inhibitor DMTCR2O RN Tecarfarin, a novel vitamin K reductase antagonist, is not affected by CYP2C9 and CYP3A4 inhibition following concomitant administration of fluconazole in healthy participants. J Clin Pharmacol. 2011Apr;51(4):561-74. DMTCR2O RU https://pubmed.ncbi.nlm.nih.gov/20622200 DMKE187 DI DMKE187 DMKE187 DN Telmisartan DMKE187 MI TTPKMXQ DMKE187 MN HUMAN type-1 angiotensin II receptor (AGTR1) DMKE187 MT DTT DMKE187 MA Blocker DMKE187 RN Controversies of renin-angiotensin system inhibition during the COVID-19 pandemic. Nat Rev Nephrol. 2020 Apr 3. DMKE187 RU https://pubmed.ncbi.nlm.nih.gov/32246101 DMHQRYE DI DMHQRYE DMHQRYE DN Tenidap DMHQRYE MI TT2J34L DMHQRYE MN Arachidonate 5-lipoxygenase (5-LOX) DMHQRYE MT DTT DMHQRYE MA Modulator DMHQRYE RN The in vitro free radical scavenging activity of tenidap, a new dual cyclo-oxygenase and 5-1ipoxygenase inhibitor. Mediators Inflamm. 1992;1(2):141-3. DMHQRYE RU https://pubmed.ncbi.nlm.nih.gov/18475454 DMHOV7D DI DMHOV7D DMHOV7D DN Tenofovir alafenamide DMHOV7D MI DTI7UX6 DMHOV7D MN Breast cancer resistance protein (ABCG2) DMHOV7D MT DTP DMHOV7D MA Substrate DMHOV7D RN Pharmacokinetics of Tenofovir Alafenamide When Coadministered With Other HIV Antiretrovirals. J Acquir Immune Defic Syndr. 2018 Aug 1;78(4):465-472. DMHOV7D RU http://www.ncbi.nlm.nih.gov/pubmed/29649076 DMHOV7D DI DMHOV7D DMHOV7D DN Tenofovir alafenamide DMHOV7D MI DTUGYRD DMHOV7D MN P-glycoprotein 1 (ABCB1) DMHOV7D MT DTP DMHOV7D MA Substrate DMHOV7D RN Pharmacokinetics of Tenofovir Alafenamide When Coadministered With Other HIV Antiretrovirals. J Acquir Immune Defic Syndr. 2018 Aug 1;78(4):465-472. DMHOV7D RU http://www.ncbi.nlm.nih.gov/pubmed/29649076 DMZ3P6C DI DMZ3P6C DMZ3P6C DN Teplizumab DMZ3P6C MI TTBMAOZ DMZ3P6C MN Regulatory protein unspecific (RGP) DMZ3P6C MT DTT DMZ3P6C RN Acquisition of regulatory function by human CD8(+) T cells treated with anti-CD3 antibody requires TNF. Eur J Immunol. 2010 Oct;40(10):2891-901. DMZ3P6C RU https://pubmed.ncbi.nlm.nih.gov/21038470 DMZ3P6C DI DMZ3P6C DMZ3P6C DN Teplizumab DMZ3P6C MI TTV3XPL DMZ3P6C MN T-cell surface glycoprotein CD3 gamma (CD3G) DMZ3P6C MT DTT DMZ3P6C MA Inhibitor DMZ3P6C RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMZ3P6C RU http://phrma-docs.phrma.org/files/dmfile/mid-diabetes-drug-list.pdf DM4MZXE DI DM4MZXE DM4MZXE DN Terodiline DM4MZXE MI DE4LYSA DM4MZXE MN Cytochrome P450 3A4 (CYP3A4) DM4MZXE MT DME DM4MZXE MA Metabolism DM4MZXE RN Integrated analysis on the physicochemical properties of dihydropyridine calcium channel blockers in grapefruit juice interactions. Curr Pharm Biotechnol. 2012 Jul;13(9):1705-17. DM4MZXE RU https://www.ncbi.nlm.nih.gov/pubmed/?term=22039822 DMGRBN5 DI DMGRBN5 DMGRBN5 DN TESAGLITAZAR DMGRBN5 MI TTJ584C DMGRBN5 MN Peroxisome proliferator-activated receptor alpha (PPARA) DMGRBN5 MT DTT DMGRBN5 MA Modulator DMGRBN5 RN Tesaglitazar, a dual PPAR-/ agonist, hamster carcinogenicity, investigative animal and clinical studies.Toxicol Pathol.2012;40(1):18-32. DMGRBN5 RU https://www.ncbi.nlm.nih.gov/pubmed/22131108 DMGRBN5 DI DMGRBN5 DMGRBN5 DN TESAGLITAZAR DMGRBN5 MI TTZMAO3 DMGRBN5 MN Peroxisome proliferator-activated receptor gamma (PPAR-gamma) DMGRBN5 MT DTT DMGRBN5 MA Modulator DMGRBN5 RN Tesaglitazar, a dual PPAR-/ agonist, hamster carcinogenicity, investigative animal and clinical studies.Toxicol Pathol.2012;40(1):18-32. DMGRBN5 RU https://www.ncbi.nlm.nih.gov/pubmed/22131108 DMMTKC6 DI DMMTKC6 DMMTKC6 DN TEV-48125 DMMTKC6 MI TTAFORY DMMTKC6 MN Calcitonin gene-related peptide (CALC) DMMTKC6 MT DTT DMMTKC6 RN TEV-48125 for the preventive treatment of chronic migraine: Efficacy at early time points. Neurology. 2016 Jul 5;87(1):41-8. DMMTKC6 RU https://pubmed.ncbi.nlm.nih.gov/27281531 DM9R5J6 DI DM9R5J6 DM9R5J6 DN Tezepelumab DM9R5J6 MI TTHMW3T DM9R5J6 MN Thymic stromal lymphopoietin (TSLP) DM9R5J6 MT DTT DM9R5J6 RN Tezepelumab in Adults with Uncontrolled Asthma. N Engl J Med. 2017 Sep 7;377(10):936-946. DM9R5J6 RU https://pubmed.ncbi.nlm.nih.gov/28877011 DMLCXPD DI DMLCXPD DMLCXPD DN TG-C DMLCXPD MI TTR9XHZ DMLCXPD MN Transforming growth factor beta 1 (TGFB1) DMLCXPD MT DTT DMLCXPD MA Modulator DMLCXPD RN Clinical pipeline report, company report or official report of Tissue Gene, Inc. DMLCXPD RU http://www.tissuegene.com/products/cartilage.html DMPGH7N DI DMPGH7N DMPGH7N DN ThermoProfen DMPGH7N MI TT8NGED DMPGH7N MN Prostaglandin G/H synthase 1 (COX-1) DMPGH7N MT DTT DMPGH7N MA Inhibitor DMPGH7N RN Topical NSAID therapy for musculoskeletal pain. Pain Med. 2010 Apr;11(4):535-49. DMPGH7N RU https://pubmed.ncbi.nlm.nih.gov/20210866 DMPGH7N DI DMPGH7N DMPGH7N DN ThermoProfen DMPGH7N MI TTVKILB DMPGH7N MN Prostaglandin G/H synthase 2 (COX-2) DMPGH7N MT DTT DMPGH7N MA Inhibitor DMPGH7N RN Topical NSAID therapy for musculoskeletal pain. Pain Med. 2010 Apr;11(4):535-49. DMPGH7N RU https://pubmed.ncbi.nlm.nih.gov/20210866 DM3PA8H DI DM3PA8H DM3PA8H DN THVD-201 DM3PA8H MI TTOXS3C DM3PA8H MN Muscarinic acetylcholine receptor (CHRM) DM3PA8H MT DTT DM3PA8H MA Agonist DM3PA8H RN Future therapies: Early trials and basic science. Can Urol Assoc J. 2013 Sep-Oct; 7(9-10 Suppl 4): S179-S180. 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DMMO6P0 RU https://pubmed.ncbi.nlm.nih.gov/12851279 DMZBGI8 DI DMZBGI8 DMZBGI8 DN Tilarginine acetate DMZBGI8 MI TTCM4B3 DMZBGI8 MN Nitric-oxide synthase endothelial (NOS3) DMZBGI8 MT DTT DMZBGI8 MA Modulator DMZBGI8 RN Effect of tilarginine acetate in patients with acute myocardial infarction and cardiogenic shock: the TRIUMPH randomized controlled trial. JAMA. 2007 Apr 18;297(15):1657-66. DMZBGI8 RU https://pubmed.ncbi.nlm.nih.gov/17387132 DMGYK2N DI DMGYK2N DMGYK2N DN Tilsotolimod DMGYK2N MI TTSHG0T DMGYK2N MN Toll-like receptor 9 (TLR9) DMGYK2N MT DTT DMGYK2N MA Agonist DMGYK2N RN Tilsotolimod with ipilimumab drives tumor responses in anti-PD-1 refractory melanoma. Cancer Discov. 2021 Mar 11;candisc.1546.2020. DMGYK2N RU https://pubmed.ncbi.nlm.nih.gov/33707233 DMBFE4K DI DMBFE4K DMBFE4K DN Tirapazamine DMBFE4K MI DEVDYN7 DMBFE4K MN Cytochrome P450 2E1 (CYP2E1) DMBFE4K MT DME DMBFE4K MA Metabolism DMBFE4K RN Molecular mechanisms of tirapazamine (SR 4233, Win 59075)-induced hepatocyte toxicity under low oxygen concentrations. Br J Cancer. 1995 Apr;71(4):780-5. DMBFE4K RU https://www.ncbi.nlm.nih.gov/pubmed/?term=7710944 DMBFE4K DI DMBFE4K DMBFE4K DN Tirapazamine DMBFE4K MI TT0IHXV DMBFE4K MN DNA topoisomerase II (TOP2) DMBFE4K MT DTT DMBFE4K MA Modulator DMBFE4K RN Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41. DMBFE4K RU https://www.ncbi.nlm.nih.gov/pubmed/15950434 DMQNMAT DI DMQNMAT DMQNMAT DN Tirzepatide DMQNMAT MI TTVIMDE DMQNMAT MN Glucagon-like peptide 1 receptor (GLP1R) DMQNMAT MT DTT DMQNMAT MA Agonist DMQNMAT RN Dual GIP and GLP-1 Receptor Agonist Tirzepatide Improves Beta-cell Function and Insulin Sensitivity in Type 2 Diabetes. J Clin Endocrinol Metab. 2021 Jan 23;106(2):388-396. DMQNMAT RU https://pubmed.ncbi.nlm.nih.gov/33236115 DM95IPS DI DM95IPS DM95IPS DN Tivanisiran DM95IPS MI TT50OG3 DM95IPS MN TRPV1 messenger RNA (TRPV1 mRNA) DM95IPS MT DTT DM95IPS MA Inhibitor DM95IPS RN Tivanisiran, a novel siRNA for the treatment of dry eye disease. Expert Opin Investig Drugs. 2018 Apr;27(4):421-426. DM95IPS RU https://pubmed.ncbi.nlm.nih.gov/29569947 DMNVP8Q DI DMNVP8Q DMNVP8Q DN Tivantinib DMNVP8Q MI TTNDSF4 DMNVP8Q MN Proto-oncogene c-Met (MET) DMNVP8Q MT DTT DMNVP8Q MA Inhibitor DMNVP8Q RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7948). DMNVP8Q RU http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=7948 DMYLT67 DI DMYLT67 DMYLT67 DN TKI258 DMYLT67 MI DEJGDUW DMYLT67 MN Cytochrome P450 1A2 (CYP1A2) DMYLT67 MT DME DMYLT67 MA Metabolism DMYLT67 RN A drug-drug interaction study to assess the effect of the CYP1A2 inhibitor fluvoxamine on the pharmacokinetics of dovitinib (TKI258) in patients with advanced solid tumors. Cancer Chemother Pharmacol. 2018 Jan;81(1):73-80. DMYLT67 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=29101463 DMYLT67 DI DMYLT67 DMYLT67 DN TKI258 DMYLT67 MI TTST7KB DMYLT67 MN Fibroblast growth factor receptor 3 (FGFR3) DMYLT67 MT DTT DMYLT67 MA Inhibitor DMYLT67 RN A comparison of physicochemical property profiles of marketed oral drugs and orally bioavailable anti-cancer protein kinase inhibitors in clinical development. Curr Top Med Chem. 2007;7(14):1408-22. DMYLT67 RU https://pubmed.ncbi.nlm.nih.gov/17692029 DMYLT67 DI DMYLT67 DMYLT67 DN TKI258 DMYLT67 MI TTI2WET DMYLT67 MN Platelet-derived growth factor receptor (PDGFR) DMYLT67 MT DTT DMYLT67 MA Inhibitor DMYLT67 RN A comparison of physicochemical property profiles of marketed oral drugs and orally bioavailable anti-cancer protein kinase inhibitors in clinical development. Curr Top Med Chem. 2007;7(14):1408-22. DMYLT67 RU https://pubmed.ncbi.nlm.nih.gov/17692029 DMO1234 DI DMO1234 DMO1234 DN TNX-102 DMO1234 MI TTJQOD7 DMO1234 MN 5-HT 2A receptor (HTR2A) DMO1234 MT DTT DMO1234 MA Antagonist DMO1234 RN Clinical pipeline report, company report or official report of Tonix Pharmaceuticals. DMO1234 RU http://www.tonixpharma.com/research-development/tnx-102-sl-for-fibromyalgia DMO1234 DI DMO1234 DMO1234 DN TNX-102 DMO1234 MI TT2NUT5 DMO1234 MN Adrenergic receptor alpha-2C (ADRA2C) DMO1234 MT DTT DMO1234 MA Antagonist DMO1234 RN Clinical pipeline report, company report or official report of Tonix Pharmaceuticals. DMO1234 RU http://www.tonixpharma.com/research-development/tnx-102-sl-for-fibromyalgia DMYA41S DI DMYA41S DMYA41S DN TNX-355 DMYA41S MI TTN2JFW DMYA41S MN T-cell surface glycoprotein CD4 (CD4) DMYA41S MT DTT DMYA41S MA Binder DMYA41S RN Progress in targeting HIV-1 entry. Drug Discov Today. 2005 Aug 15;10(16):1085-94. DMYA41S RU https://pubmed.ncbi.nlm.nih.gov/16182193 DMFDNT0 DI DMFDNT0 DMFDNT0 DN Tocilizumab DMFDNT0 MI TTDVAKP DMFDNT0 MN HUMAN interleukin-6 receptor (IL6R) DMFDNT0 MT DTT DMFDNT0 MA Inhibitor DMFDNT0 RN Tocilizumab, an anti-IL6 receptor antibody, to treat Covid-19-related respiratory failure: a case report. Ann Oncol. 2020 Apr 2. pii: S0923-7534(20)36387-0. DMFDNT0 RU https://pubmed.ncbi.nlm.nih.gov/32247642 DMATC14 DI DMATC14 DMATC14 DN Tozadenant DMATC14 MI TTM2AOE DMATC14 MN Adenosine A2a receptor (ADORA2A) DMATC14 MT DTT DMATC14 MA Antagonist DMATC14 RN Tozadenant (SYN115) in patients with Parkinson's disease who have motor fluctuations on levodopa: a phase 2b, double-blind, randomised trial. Lancet Neurol. 2014 Aug;13(8):767-76. DMATC14 RU https://pubmed.ncbi.nlm.nih.gov/25008546 DMLKI2B DI DMLKI2B DMLKI2B DN Trafermin DMLKI2B MI TTGJVQM DMLKI2B MN Fibroblast growth factor receptor 2 (FGFR2) DMLKI2B MT DTT DMLKI2B MA Activator DMLKI2B RN Emerging drugs for diabetic foot ulcers. Expert Opin Emerg Drugs. 2006 Nov;11(4):709-24. DMLKI2B RU https://pubmed.ncbi.nlm.nih.gov/17064227 DM6ENSJ DI DM6ENSJ DM6ENSJ DN Tralokinumab DM6ENSJ MI TTMPZ7V DM6ENSJ MN Interleukin 13 receptor alpha-2 (IL13RA2) DM6ENSJ MT DTT DM6ENSJ MA Modulator DM6ENSJ RN Targeting interleukin-13 with tralokinumab attenuates lung fibrosis and epithelial damage in a humanized SCID idiopathic pulmonary fibrosis model.Am J Respir Cell Mol Biol.2014 May;50(5):985-94. DM6ENSJ RU https://www.ncbi.nlm.nih.gov/pubmed/24325475 DM6ENSJ DI DM6ENSJ DM6ENSJ DN Tralokinumab DM6ENSJ MI TT0GVCH DM6ENSJ MN Interleukin-13 (IL13) DM6ENSJ MT DTT DM6ENSJ MA Inhibitor DM6ENSJ RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DM6ENSJ RU http://phrma-docs.phrma.org/files/dmfile/MID_Skin_Diseases_2018_9_FINAL.pdf DM7BSRH DI DM7BSRH DM7BSRH DN Tramiprosate DM7BSRH MI TTE4KHA DM7BSRH MN Amyloid beta A4 protein (APP) DM7BSRH MT DTT DM7BSRH MA Antagonist DM7BSRH RN Targeting soluble Abeta peptide with Tramiprosate for the treatment of brain amyloidosis. Neurobiol Aging. 2007 Apr;28(4):537-47. DM7BSRH RU https://pubmed.ncbi.nlm.nih.gov/16675063 DMLB3I4 DI DMLB3I4 DMLB3I4 DN Trastuzumab-DM1 DMLB3I4 MI TT6EO5L DMLB3I4 MN Erbb2 tyrosine kinase receptor (HER2) DMLB3I4 MT DTT DMLB3I4 RN Clinical pipeline report, company report or official report of Genentech (2009). DMLB3I4 RU http://www.gene.com/gene/pipeline/status/ DM1874J DI DM1874J DM1874J DN TRC105 DM1874J MI TTB30LE DM1874J MN Endoglin CD105 (ENG) DM1874J MT DTT DM1874J MA Modulator DM1874J RN An open-label phase Ib dose-escalation study of TRC105 (anti-endoglin antibody) with bevacizumab in patients with advanced cancer. Clin Cancer Res. 2014 Dec 1;20(23):5918-26. DM1874J RU https://pubmed.ncbi.nlm.nih.gov/25261556 DMOG2X1 DI DMOG2X1 DMOG2X1 DN Trebananib DMOG2X1 MI TTWNQ1T DMOG2X1 MN Angiopoietin-1 (ANGPT1) DMOG2X1 MT DTT DMOG2X1 MA Inhibitor DMOG2X1 RN Pediatric Phase I Trial and Pharmacokinetic Study of Trebananib in Relapsed Solid Tumors, Including Primary Tumors of the Central Nervous System ADVL1115: A Children's Oncology Group Phase I Consortium Report. Clin Cancer Res. 2017 Oct 15;23(20):6062-6069. DMOG2X1 RU https://pubmed.ncbi.nlm.nih.gov/28751444 DMOG2X1 DI DMOG2X1 DMOG2X1 DN Trebananib DMOG2X1 MI TTKLQTJ DMOG2X1 MN Angiopoietin-2 (ANGPT2) DMOG2X1 MT DTT DMOG2X1 MA Inhibitor DMOG2X1 RN Pediatric Phase I Trial and Pharmacokinetic Study of Trebananib in Relapsed Solid Tumors, Including Primary Tumors of the Central Nervous System ADVL1115: A Children's Oncology Group Phase I Consortium Report. Clin Cancer Res. 2017 Oct 15;23(20):6062-6069. DMOG2X1 RU https://pubmed.ncbi.nlm.nih.gov/28751444 DMOQ9H1 DI DMOQ9H1 DMOQ9H1 DN Tremelimumab DMOQ9H1 MI TTI2S1D DMOQ9H1 MN Cytotoxic T-lymphocyte protein 4 (CTLA-4) DMOQ9H1 MT DTT DMOQ9H1 MA Modulator DMOQ9H1 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2743). DMOQ9H1 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2743 DMS57DJ DI DMS57DJ DMS57DJ DN Trimegestone/ethinyl estradiol DMS57DJ MI TTZAYWL DMS57DJ MN Estrogen receptor (ESR) DMS57DJ MT DTT DMS57DJ MA Modulator DMS57DJ RN Differential effects of estrogens and progestins on the anticoagulant tissue factor pathway inhibitor in the rat. J Steroid Biochem Mol Biol. 2005 Mar;94(4):361-8. DMS57DJ RU https://pubmed.ncbi.nlm.nih.gov/15857755 DMCMDVR DI DMCMDVR DMCMDVR DN Triptolide DMCMDVR MI DE4LYSA DMCMDVR MN Cytochrome P450 3A4 (CYP3A4) DMCMDVR MT DME DMCMDVR MA Metabolism DMCMDVR RN Preclinical pharmacokinetics of triptolide: a potential antitumor drug. Curr Drug Metab. 2019;20(2):147-154. DMCMDVR RU https://www.ncbi.nlm.nih.gov/pubmed/?term=30112986 DMCMDVR DI DMCMDVR DMCMDVR DN Triptolide DMCMDVR MI TTSXVID DMCMDVR MN Nuclear factor NF-kappa-B (NFKB) DMCMDVR MT DTT DMCMDVR MA Inhibitor DMCMDVR RN Functional p53 is required for triptolide-induced apoptosis and AP-1 and nuclear factor-kappaB activation in gastric cancer cells. Oncogene. 2001 Nov 29;20(55):8009-18. DMCMDVR RU https://pubmed.ncbi.nlm.nih.gov/11753684 DMHDNK0 DI DMHDNK0 DMHDNK0 DN TroVax DMHDNK0 MI TT70MLA DMHDNK0 MN Oncotrophoblast glycoprotein 5T4 (TPBG) DMHDNK0 MT DTT DMHDNK0 RN Vaccination of metastatic renal cancer patients with MVA-5T4: a randomized, double-blind, placebo-controlled phase III study. Clin Cancer Res. 2010 Nov 15;16(22):5539-47. DMHDNK0 RU https://pubmed.ncbi.nlm.nih.gov/20881001 DM0QNF4 DI DM0QNF4 DM0QNF4 DN TRx0237 DM0QNF4 MI TTS87KH DM0QNF4 MN Microtubule-associated protein tau (MAPT) DM0QNF4 MT DTT DM0QNF4 MA Inhibitor DM0QNF4 RN Mechanisms of Anticholinesterase Interference with Tau Aggregation Inhibitor Activity in a Tau-Transgenic Mouse Model. Curr Alzheimer Res. 2020;17(3):285-296. DM0QNF4 RU https://pubmed.ncbi.nlm.nih.gov/32091331 DMAFPHB DI DMAFPHB DMAFPHB DN TRYPTAMINE DMAFPHB MI TTJQOD7 DMAFPHB MN 5-HT 2A receptor (HTR2A) DMAFPHB MT DTT DMAFPHB MA Inhibitor DMAFPHB RN Central serotonin receptors as targets for drug research. J Med Chem. 1987 Jan;30(1):1-12. DMAFPHB RU https://pubmed.ncbi.nlm.nih.gov/3543362 DMAFPHB DI DMAFPHB DMAFPHB DN TRYPTAMINE DMAFPHB MI TT3WG5C DMAFPHB MN Monoamine oxidase type A (MAO-A) DMAFPHB MT DTT DMAFPHB MA Inhibitor DMAFPHB RN Binding of beta-carbolines at imidazoline I2 receptors: a structure-affinity investigation. Bioorg Med Chem Lett. 2004 Feb 23;14(4):999-1002. DMAFPHB RU https://pubmed.ncbi.nlm.nih.gov/15013009 DMAFPHB DI DMAFPHB DMAFPHB DN TRYPTAMINE DMAFPHB MI TTGP7BY DMAFPHB MN Monoamine oxidase type B (MAO-B) DMAFPHB MT DTT DMAFPHB MA Inhibitor DMAFPHB RN Binding of beta-carbolines at imidazoline I2 receptors: a structure-affinity investigation. Bioorg Med Chem Lett. 2004 Feb 23;14(4):999-1002. DMAFPHB RU https://pubmed.ncbi.nlm.nih.gov/15013009 DMPBJ8W DI DMPBJ8W DMPBJ8W DN Turoctocog alfa DMPBJ8W MI TT1290U DMPBJ8W MN Coagulation factor VIII (F8) DMPBJ8W MT DTT DMPBJ8W MA Modulator DMPBJ8W RN The pharmacokinetics of a B-domain truncated recombinant factor VIII, turoctocog alfa (NovoEight ), in patients with hemophilia A. J Thromb Haemost. 2015 Mar;13(3):370-9. DMPBJ8W RU https://pubmed.ncbi.nlm.nih.gov/25495795 DM71ZL6 DI DM71ZL6 DM71ZL6 DN TZTX-001 DM71ZL6 MI TTZAYWL DM71ZL6 MN Estrogen receptor (ESR) DM71ZL6 MT DTT DM71ZL6 MA Modulator DM71ZL6 RN Clinical pipeline report, company report or official report of Pharmabiz. DM71ZL6 RU http://www.pharmabiz.com/PrintArticle.aspx?aid=77569&sid=2 DMN72OM DI DMN72OM DMN72OM DN U300 DMN72OM MI TTZOPHG DMN72OM MN Insulin (INS) DMN72OM MT DTT DMN72OM MA Modulator DMN72OM RN U300, a novel long-acting insulin formulation. Expert Opin Biol Ther. 2014 Dec;14(12):1849-60. DMN72OM RU https://pubmed.ncbi.nlm.nih.gov/25311556 DMHTY9W DI DMHTY9W DMHTY9W DN Ublituximab DMHTY9W MI TTUE541 DMHTY9W MN Leukocyte surface antigen Leu-16 (CD20) DMHTY9W MT DTT DMHTY9W RN The optimized anti-CD20 monoclonal antibody ublituximab bypasses natural killer phenotypic features in Waldenstr m macroglobulinemia. Haematologica. 2015 Apr;100(4):e147-51. DMHTY9W RU https://pubmed.ncbi.nlm.nih.gov/25552707 DMKUOVP DI DMKUOVP DMKUOVP DN Ublituximab + umbralisib DMKUOVP MI TTUE541 DMKUOVP MN Leukocyte surface antigen Leu-16 (CD20) DMKUOVP MT DTT DMKUOVP RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMKUOVP RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DM90AG2 DI DM90AG2 DM90AG2 DN Ularitide DM90AG2 MI TTJME02 DM90AG2 MN Atrial natriuretic peptide receptor A (NPR1) DM90AG2 MT DTT DM90AG2 MA Modulator DM90AG2 RN Ularitide for the treatment of acute decompensated heart failure: from preclinical to clinical studies. Eur Heart J. 2015 Mar 21;36(12):715-23. DM90AG2 RU https://pubmed.ncbi.nlm.nih.gov/25670819 DMIQCFG DI DMIQCFG DMIQCFG DN Ulinastatin DMIQCFG MI TT2WR1T DMIQCFG MN Cationic trypsinogen (PRSS1) DMIQCFG MT DTT DMIQCFG MA Modulator DMIQCFG RN Intravenous administration of ulinastatin (human urinary trypsin inhibitor) in severe sepsis: a multicenter randomized controlled study. Intensive Care Med. 2014 Jun;40(6):830-8. DMIQCFG RU https://pubmed.ncbi.nlm.nih.gov/24737258 DM6PMNR DI DM6PMNR DM6PMNR DN Ulocuplumab DM6PMNR MI TTBID49 DM6PMNR MN C-X-C chemokine receptor type 4 (CXCR4) DM6PMNR MT DTT DM6PMNR MA Antagonist DM6PMNR RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DM6PMNR RU http://phrma-docs.phrma.org/files/dmfile/MID_Immuno-Oncology-2017_Drug-List1.pdf DMCWM03 DI DMCWM03 DMCWM03 DN Unfractionated heparin DMCWM03 MI TT4QPUL DMCWM03 MN Antithrombin-III (ATIII) DMCWM03 MT DTT DMCWM03 MA Modulator DMCWM03 RN Heparin with low affinity to antithrombin III inhibits the activation of prothrombin in normal plasma. Thromb Res. 1982 Nov 15;28(4):487-97. DMCWM03 RU https://pubmed.ncbi.nlm.nih.gov/7164033 DM0DIEZ DI DM0DIEZ DM0DIEZ DN UNI-rhIL-11 DM0DIEZ MI TTZPLJS DM0DIEZ MN Interleukin 11 receptor alpha (IL11RA) DM0DIEZ MT DTT DM0DIEZ MA Modulator DM0DIEZ RN Clinical study of rhIL-11 for prevention and treatment of chemotherapy-induced thrombocytopenia. Ai Zheng. 2002 Aug;21(8):892-5. DM0DIEZ RU https://pubmed.ncbi.nlm.nih.gov/12478901 DMM2OZH DI DMM2OZH DMM2OZH DN Ushercell DMM2OZH MI TTAUG8D DMM2OZH MN Human immunodeficiency virus Transmission (HIV Tran) DMM2OZH MT DTT DMM2OZH MA Modulator DMM2OZH RN Short Communication: Enhancement of HIV Infection by Cellulose Sulfate. AIDS Res Hum Retroviruses. 2008 July; 24(7): 925-929. DMM2OZH RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2927036/ DMD2O0L DI DMD2O0L DMD2O0L DN UX-001 DMD2O0L MI TTQ8J1V DMD2O0L MN Bacterial Deoxy-manno-octulosonate cytidylyltransferase (Bact kdsB) DMD2O0L MT DTT DMD2O0L MA Inhibitor DMD2O0L RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMD2O0L RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMD2O0L DI DMD2O0L DMD2O0L DN UX-001 DMD2O0L MI TT50QJ3 DMD2O0L MN Influenza Neuraminidase (Influ NA) DMD2O0L MT DTT DMD2O0L MA Inhibitor DMD2O0L RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMD2O0L RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMDCFXJ DI DMDCFXJ DMDCFXJ DN Vaborbactam DMDCFXJ MI TTHI19T DMDCFXJ MN Staphylococcus Beta-lactamase (Stap-coc blaZ) DMDCFXJ MT DTT DMDCFXJ MA Inhibitor DMDCFXJ RN Vaborbactam: Spectrum of Beta-Lactamase Inhibition and Impact of Resistance Mechanisms on Activity in Enterobacteriaceae. Antimicrob Agents Chemother. 2017 Oct 24;61(11):e01443-17. DMDCFXJ RU https://pubmed.ncbi.nlm.nih.gov/28848018 DM9LH10 DI DM9LH10 DM9LH10 DN Vadastuximab talirine DM9LH10 MI TTJVYO3 DM9LH10 MN Myeloid cell surface antigen CD33 (CD33) DM9LH10 MT DTT DM9LH10 MA Antagonist DM9LH10 RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DM9LH10 RU http://phrma-docs.phrma.org/files/dmfile/MID_Immuno-Oncology-2017_Drug-List1.pdf DM9J5Q4 DI DM9J5Q4 DM9J5Q4 DN VAL-083 DM9J5Q4 MI TTUTN1I DM9J5Q4 MN Human Deoxyribonucleic acid (hDNA) DM9J5Q4 MT DTT DM9J5Q4 MA Modulator DM9J5Q4 RN Effect of 1,2:5,6-dianhydrogalactitol and 1,2:5,6-dianhydro-3,4-diacetylgalactitol on DNA synthesis in the cells of melanoma B16, bone marrow, small intestine epithelium, spleen and liver of mice. Biull Eksp Biol Med. 1984 Sep;98(9):301-3. DM9J5Q4 RU https://pubmed.ncbi.nlm.nih.gov/6487788 DMMKE2H DI DMMKE2H DMMKE2H DN Valoctocogene roxaparvovec DMMKE2H MI TT1290U DMMKE2H MN Coagulation factor VIII (F8) DMMKE2H MT DTT DMMKE2H MA Replacement DMMKE2H RN Clinical pipeline report, company report or official report of BioMarin Pharmaceutical. DMMKE2H RU https://www.biomarin.com/our-treatments/pipeline/ DMQL0KF DI DMQL0KF DMQL0KF DN Vanadate DMQL0KF MI TTZVSJ2 DMQL0KF MN Sarcoplasmic/endoplasmic reticulum calcium ATPase (ATP2A) DMQL0KF MT DTT DMQL0KF MA Inhibitor DMQL0KF RN Expression and functional characterization of a Plasmodium falciparum Ca2+-ATPase (PfATP4) belonging to a subclass unique to apicomplexan organisms. J Biol Chem. 2001 Apr 6;276(14):10782-7. DMQL0KF RU https://pubmed.ncbi.nlm.nih.gov/11145964 DMLIMEA DI DMLIMEA DMLIMEA DN Varespladib methyl DMLIMEA MI TT2XHSJ DMLIMEA MN Secretory phospholipase A2 (sPLA2) DMLIMEA MT DTT DMLIMEA MA Modulator DMLIMEA RN Varespladib. Am J Cardiovasc Drugs. 2011;11(2):137-43. DMLIMEA RU https://pubmed.ncbi.nlm.nih.gov/21446779 DMANKTO DI DMANKTO DMANKTO DN Vatreptacog alfa (activated) DMANKTO MI TTF0EGX DMANKTO MN Coagulation factor VII (F7) DMANKTO MT DTT DMANKTO MA Modulator DMANKTO RN Recombinant factor VIIa analog (vatreptacog alfa [activated]) for treatment of joint bleeds in hemophilia patients with inhibitors: a randomized controlled trial. J Thromb Haemost. 2012 Jan;10(1):81-9. DMANKTO RU https://pubmed.ncbi.nlm.nih.gov/22470921 DMX04CA DI DMX04CA DMX04CA DN VB-111 DMX04CA MI TTF0RCZ DMX04CA MN Apoptosis mediating surface antigen FAS (FAS) DMX04CA MT DTT DMX04CA MA Modulator DMX04CA RN Phase I dose-escalation study of VB-111, an antiangiogenic virotherapy, in patients with advanced solid tumors.Clin Cancer Res.2013 Jul 15;19(14):3996-4007. DMX04CA RU https://www.ncbi.nlm.nih.gov/pubmed/23589178 DMX04CA DI DMX04CA DMX04CA DN VB-111 DMX04CA MI TTG043C DMX04CA MN Tumor necrosis factor receptor type I (TNF-R1) DMX04CA MT DTT DMX04CA MA Modulator DMX04CA RN Phase I dose-escalation study of VB-111, an antiangiogenic virotherapy, in patients with advanced solid tumors.Clin Cancer Res.2013 Jul 15;19(14):3996-4007. DMX04CA RU https://www.ncbi.nlm.nih.gov/pubmed/23589178 DMXHI89 DI DMXHI89 DMXHI89 DN Velac Gel DMXHI89 MI TTOD7B3 DMXHI89 MN Retinoic acid receptor (RAR) DMXHI89 MT DTT DMXHI89 MA Inhibitor DMXHI89 RN Chromosomal translocation t(15;17) in human acute promyelocytic leukemia fuses RAR alpha with a novel putative transcription factor, PML. Cell. 1991 Aug 23;66(4):663-74. DMXHI89 RU https://pubmed.ncbi.nlm.nih.gov/1652368 DMJBU9V DI DMJBU9V DMJBU9V DN Velimogene aliplasmid DMJBU9V MI TTGS10J DMJBU9V MN HLA class I antigen B-7 (HLA-B) DMJBU9V MT DTT DMJBU9V MA Modulator DMJBU9V RN Velimogene aliplasmid. Expert Opin Biol Ther. 2010 May;10(5):841-51. DMJBU9V RU https://pubmed.ncbi.nlm.nih.gov/20367461 DM6L5ZQ DI DM6L5ZQ DM6L5ZQ DN Vercirnon DM6L5ZQ MI TTIPS8B DM6L5ZQ MN C-C chemokine receptor type 9 (CCR9) DM6L5ZQ MT DTT DM6L5ZQ MA Modulator DM6L5ZQ RN GSK-1605786, a selective small-molecule antagonist of the CCR9 chemokine receptor for the treatment of Crohn's disease. IDrugs. 2010 Jul;13(7):472-81. DM6L5ZQ RU https://pubmed.ncbi.nlm.nih.gov/20582872 DMOQ81Y DI DMOQ81Y DMOQ81Y DN Vernakalant DMOQ81Y MI DECB0K3 DMOQ81Y MN Cytochrome P450 2D6 (CYP2D6) DMOQ81Y MT DME DMOQ81Y MA Metabolism DMOQ81Y RN Pharmacokinetics of novel atrial-selective antiarrhythmic agent vernakalant hydrochloride injection (RSD1235): influence of CYP2D6 expression and other factors. J Clin Pharmacol. 2009 Jan;49(1):17-29. DMOQ81Y RU https://www.ncbi.nlm.nih.gov/pubmed/?term=18927241 DM4CGH5 DI DM4CGH5 DM4CGH5 DN verubecestat DM4CGH5 MI TT8JRS7 DM4CGH5 MN Beta-secretase (BACE) DM4CGH5 MT DTT DM4CGH5 MA Modulator DM4CGH5 RN BACE1 inhibitor drugs in clinical trials for Alzheimer's disease. Alzheimers Res Ther. 2014 Dec 24;6(9):89. DM4CGH5 RU https://pubmed.ncbi.nlm.nih.gov/25621019 DM4CGH5 DI DM4CGH5 DM4CGH5 DN verubecestat DM4CGH5 MI TTJUNZF DM4CGH5 MN Beta-secretase 1 (BACE1) DM4CGH5 MT DTT DM4CGH5 MA Inhibitor DM4CGH5 RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DM4CGH5 RU http://phrma-docs.phrma.org/files/dmfile/MID-Update_Alzheimers-Disease_2017-Drug-List.pdf DMMQ2U9 DI DMMQ2U9 DMMQ2U9 DN VGX-3100 DMMQ2U9 MI TTE2N95 DMMQ2U9 MN Human papillomavirus protein E6 (HPV E6) DMMQ2U9 MT DTT DMMQ2U9 MA Modulator DMMQ2U9 RN Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41. DMMQ2U9 RU https://www.ncbi.nlm.nih.gov/pubmed/15950434 DMMQ2U9 DI DMMQ2U9 DMMQ2U9 DN VGX-3100 DMMQ2U9 MI TT3CPZW DMMQ2U9 MN Human papillomavirus protein E7 (HPV E7) DMMQ2U9 MT DTT DMMQ2U9 MA Modulator DMMQ2U9 RN Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41. DMMQ2U9 RU https://www.ncbi.nlm.nih.gov/pubmed/15950434 DMCWNZG DI DMCWNZG DMCWNZG DN Vibegron DMCWNZG MI DTUGYRD DMCWNZG MN P-glycoprotein 1 (ABCB1) DMCWNZG MT DTP DMCWNZG MA Substrate DMCWNZG RN KEGG: new perspectives on genomes, pathways, diseases and drugs. Nucleic Acids Res. 2017 Jan 4;45(D1):D353-D361. (dg:DG01665) DMCWNZG RU https://www.kegg.jp/dbget-bin/www_bget?dg:DG01665 DMLO0KD DI DMLO0KD DMLO0KD DN Vicineum DMLO0KD MI TTZ8WH4 DMLO0KD MN Tumor-associated calcium signal transducer 1 (EPCAM) DMLO0KD MT DTT DMLO0KD RN Clinical pipeline report, company report or official report of Sesen Bio. DMLO0KD RU https://sesenbio.com/our-programs/ DMMTW9K DI DMMTW9K DMMTW9K DN Vicriviroc DMMTW9K MI TT2CEJG DMMTW9K MN C-C chemokine receptor type 5 (CCR5) DMMTW9K MT DTT DMMTW9K MA Antagonist DMMTW9K RN HIV entry: new insights and implications for patient management. Curr Opin Infect Dis. 2009 Feb;22(1):35-42. DMMTW9K RU https://pubmed.ncbi.nlm.nih.gov/19532079 DMMTW9K DI DMMTW9K DMMTW9K DN Vicriviroc DMMTW9K MI DE5IED8 DMMTW9K MN Cytochrome P450 2C9 (CYP2C9) DMMTW9K MT DME DMMTW9K MA Metabolism DMMTW9K RN Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. DMMTW9K RU https://www.ncbi.nlm.nih.gov/pubmed/?term=19515014 DMMTW9K DI DMMTW9K DMMTW9K DN Vicriviroc DMMTW9K MI DE4LYSA DMMTW9K MN Cytochrome P450 3A4 (CYP3A4) DMMTW9K MT DME DMMTW9K MA Metabolism DMMTW9K RN Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. DMMTW9K RU https://www.ncbi.nlm.nih.gov/pubmed/?term=19515014 DMMTW9K DI DMMTW9K DMMTW9K DN Vicriviroc DMMTW9K MI DEIBDNY DMMTW9K MN Cytochrome P450 3A5 (CYP3A5) DMMTW9K MT DME DMMTW9K MA Metabolism DMMTW9K RN Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. DMMTW9K RU https://www.ncbi.nlm.nih.gov/pubmed/?term=19515014 DMJFNR9 DI DMJFNR9 DMJFNR9 DN Viramidine DMJFNR9 MI TTL7C8Q DMJFNR9 MN Inosine-5'-monophosphate dehydrogenase 1 (IMPDH1) DMJFNR9 MT DTT DMJFNR9 MA Inhibitor DMJFNR9 RN Antiviral agents active against influenza A viruses. Nat Rev Drug Discov. 2006 Dec;5(12):1015-25. DMJFNR9 RU https://pubmed.ncbi.nlm.nih.gov/17139286 DMXYM1H DI DMXYM1H DMXYM1H DN Visilizumab DMXYM1H MI TTBMAOZ DMXYM1H MN Regulatory protein unspecific (RGP) DMXYM1H MT DTT DMXYM1H RN Visilizumab induces apoptosis of mucosal T lymphocytes in ulcerative colitis through activation of caspase 3 and 8 dependent pathways. Clin Immunol. 2008 Jun;127(3):322-9. DMXYM1H RU https://pubmed.ncbi.nlm.nih.gov/18424236 DMQGV5P DI DMQGV5P DMQGV5P DN VLB-01 DMQGV5P MI TT32JK8 DMQGV5P MN Melatonin receptor type 1B (MTNR1B) DMQGV5P MT DTT DMQGV5P MA Modulator DMQGV5P RN Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41. DMQGV5P RU https://www.ncbi.nlm.nih.gov/pubmed/15950434 DMSW80U DI DMSW80U DMSW80U DN VM-202 DMSW80U MI TT4V2JM DMSW80U MN Hepatocyte growth factor (HGF) DMSW80U MT DTT DMSW80U MA Modulator DMSW80U RN Therapeutic angiogenesis using naked DNA expressing two isoforms of the hepatocyte growth factor in a porcine acute myocardial infarction model. Eur J Cardiothorac Surg. 2008 Oct;34(4):857-63. DMSW80U RU https://pubmed.ncbi.nlm.nih.gov/18620865 DM4P5UJ DI DM4P5UJ DM4P5UJ DN VM-501 DM4P5UJ MI TTGUYTR DM4P5UJ MN Interleukin-11 (IL11) DM4P5UJ MT DTT DM4P5UJ MA Agonist DM4P5UJ RN Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800033052) DM4P5UJ RU http://adisinsight.springer.com/drugs/800033052 DMOFH1M DI DMOFH1M DMOFH1M DN Volasertib DMOFH1M MI TTIYVQP DMOFH1M MN Polo-like kinase 1 (PLK1) DMOFH1M MT DTT DMOFH1M MA Modulator DMOFH1M RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2168). DMOFH1M RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2168 DM5T4IS DI DM5T4IS DM5T4IS DN VP-102 DM5T4IS MI TTLA7IX DM5T4IS MN Protein phosphatase 1A (PPM1A) DM5T4IS MT DTT DM5T4IS MA Inhibitor DM5T4IS RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DM5T4IS RU http://phrma-docs.phrma.org/files/dmfile/MID_Skin_Diseases_2018_9_FINAL.pdf DM5T4IS DI DM5T4IS DM5T4IS DN VP-102 DM5T4IS MI TTHTKNY DM5T4IS MN Serine/threonine PP2A-alpha (PPP2CA) DM5T4IS MT DTT DM5T4IS MA Inhibitor DM5T4IS RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DM5T4IS RU http://phrma-docs.phrma.org/files/dmfile/MID_Skin_Diseases_2018_9_FINAL.pdf DMWMT5N DI DMWMT5N DMWMT5N DN VRS-317 DMWMT5N MI TTT3YKH DMWMT5N MN Somatotropin (GH1) DMWMT5N MT DTT DMWMT5N MA Modulator DMWMT5N RN Company report (Versartis) DMWMT5N RU http://www.versartis.com/content/productpipeline/vrs-317.htm DMM1Z9G DI DMM1Z9G DMM1Z9G DN Vutrisiran DMM1Z9G MI TTPOYU7 DMM1Z9G MN Transthyretin messenger RNA (TTR mRNA) DMM1Z9G MT DTT DMM1Z9G MA Inhibitor DMM1Z9G RN Clinical pipeline report, company report or official report of Alnylam Pharmaceuticals. DMM1Z9G RU https://www.alnylam.com/alnylam-rnai-pipeline/ DMJBXO3 DI DMJBXO3 DMJBXO3 DN VX-661 DMJBXO3 MI TTRLZHP DMJBXO3 MN cAMP-dependent chloride channel (CFTR) DMJBXO3 MT DTT DMJBXO3 MA Regulator DMJBXO3 RN CFTR Modulators for the Treatment of Cystic Fibrosis. P T. 2014 Jul;39(7):500-11. DMJBXO3 RU https://pubmed.ncbi.nlm.nih.gov/25083129 DMJBXO3 DI DMJBXO3 DMJBXO3 DN VX-661 DMJBXO3 MI DEIBDNY DMJBXO3 MN Cytochrome P450 3A5 (CYP3A5) DMJBXO3 MT DME DMJBXO3 MA Metabolism DMJBXO3 RN Pharmacokinetic and drug-drug interaction profiles of the combination of Tezacaftor/Ivacaftor. Clin Transl Sci. 2019 May;12(3):267-275. DMJBXO3 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=30694595 DMM2JXP DI DMM2JXP DMM2JXP DN VX-787 DMM2JXP MI TT62KQV DMM2JXP MN Influenza Polymerase basic protein 2 (Influ PB2) DMM2JXP MT DTT DMM2JXP MA Inhibitor DMM2JXP RN Discovery of a novel, first-in-class, orally bioavailable azaindole inhibitor (VX-787) of influenza PB2. J Med Chem. 2014 Aug 14;57(15):6668-78. DMM2JXP RU https://pubmed.ncbi.nlm.nih.gov/25019388 DM1JCW8 DI DM1JCW8 DM1JCW8 DN Xaliproden DM1JCW8 MI TTSQIFT DM1JCW8 MN 5-HT 1A receptor (HTR1A) DM1JCW8 MT DTT DM1JCW8 MA Antagonist DM1JCW8 RN Pharma & Vaccines. Product Development Pipeline. April 29 2009. DM1JCW8 RU http://en.sanofi-aventis.com/binaries/RD_Phase_III_EN_tcm28-24007.pdf DMK34MZ DI DMK34MZ DMK34MZ DN Xilonix DMK34MZ MI TTPM6HI DMK34MZ MN Interleukin-1 alpha (IL1A) DMK34MZ MT DTT DMK34MZ MA Modulator DMK34MZ RN Clinical pipeline report, company report or official report of xbiotech. DMK34MZ RU http://www.xbiotech.com/clinical/oncology.html DMJ6F5C DI DMJ6F5C DMJ6F5C DN XL019 DMJ6F5C MI TTRMX3V DMJ6F5C MN Janus kinase 2 (JAK-2) DMJ6F5C MT DTT DMJ6F5C MA Inhibitor DMJ6F5C RN Emerging drugs for the therapy of primary and post essential thrombocythemia, post polycythemia vera myelofibrosis. Expert Opin Emerg Drugs. 2009 Sep;14(3):471-9. DMJ6F5C RU https://pubmed.ncbi.nlm.nih.gov/19552608 DMOKQV7 DI DMOKQV7 DMOKQV7 DN XOMA 052 DMOKQV7 MI TTRYK0X DMOKQV7 MN Interleukin-1 beta (IL1B) DMOKQV7 MT DTT DMOKQV7 RN Gevokizumab, an anti-IL-1beta mAb for the potential treatment of type 1 and 2 diabetes, rheumatoid arthritis and cardiovascular disease. Curr Opin Mol Ther. 2010 Dec;12(6):755-69. DMOKQV7 RU https://pubmed.ncbi.nlm.nih.gov/21154167 DMOLR5W DI DMOLR5W DMOLR5W DN Yttrium (90Y) clivatuzumab tetraxetan DMOLR5W MI TTBHFYQ DMOLR5W MN Mucin-1 (MUC1) DMOLR5W MT DTT DMOLR5W RN Clinical pipeline report, company report or official report of Immunomedics. DMOLR5W RU http://www.immunomedics.com/clivatuzumab-demo.shtml DMEY1F3 DI DMEY1F3 DMEY1F3 DN Zabofloxacin DMEY1F3 MI TTN6J5F DMEY1F3 MN Bacterial DNA gyrase (Bact gyrase) DMEY1F3 MT DTT DMEY1F3 MA Modulator DMEY1F3 RN DNA gyrase and topoisomerase IV are dual targets of zabofloxacin in Streptococcus pneumoniae.Int J Antimicrob Agents.2010 Jul;36(1):97-8. DMEY1F3 RU https://www.ncbi.nlm.nih.gov/pubmed/20403681 DMEY1F3 DI DMEY1F3 DMEY1F3 DN Zabofloxacin DMEY1F3 MI TTIXTO3 DMEY1F3 MN Staphylococcus Topoisomerase IV (Stap-coc parC) DMEY1F3 MT DTT DMEY1F3 MA Modulator DMEY1F3 RN DNA gyrase and topoisomerase IV are dual targets of zabofloxacin in Streptococcus pneumoniae.Int J Antimicrob Agents.2010 Jul;36(1):97-8. DMEY1F3 RU https://www.ncbi.nlm.nih.gov/pubmed/20403681 DM52QEZ DI DM52QEZ DM52QEZ DN Zalutumumab DM52QEZ MI TTGKNB4 DM52QEZ MN Epidermal growth factor receptor (EGFR) DM52QEZ MT DTT DM52QEZ RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1797). DM52QEZ RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1797 DMKB4ZY DI DMKB4ZY DMKB4ZY DN Zanolimumab DMKB4ZY MI TTN2JFW DMKB4ZY MN T-cell surface glycoprotein CD4 (CD4) DMKB4ZY MT DTT DMKB4ZY RN Clinical efficacy of zanolimumab (HuMax-CD4): two phase 2 studies in refractory cutaneous T-cell lymphoma. Blood. 2007 Jun 1;109(11):4655-62. DMKB4ZY RU https://pubmed.ncbi.nlm.nih.gov/17311990 DM9HUYP DI DM9HUYP DM9HUYP DN ZANOTERONE DM9HUYP MI TTS64P2 DM9HUYP MN Androgen receptor (AR) DM9HUYP MT DTT DM9HUYP MA Inhibitor DM9HUYP RN Antiandrogenic steroidal sulfonyl heterocycles. Utility of electrostatic complementarity in defining bioisosteric sulfonyl heterocycles. J Med Chem. 1992 May 15;35(10):1663-70. DM9HUYP RU https://pubmed.ncbi.nlm.nih.gov/1588549 DMF30HL DI DMF30HL DMF30HL DN Zarnestra DMF30HL MI TTXQKM3 DMF30HL MN Farnesyl protein transferase (Ftase) DMF30HL MT DTT DMF30HL MA Modulator DMF30HL RN Tipifarnib in the treatment of newly diagnosed acute myelogenous leukemia. Biologics. 2008 Sep;2(3):491-500. DMF30HL RU https://www.ncbi.nlm.nih.gov/pubmed/19707379 DMF30HL DI DMF30HL DMF30HL DN Zarnestra DMF30HL MI TTIKWV4 DMF30HL MN Geranyltranstransferase (FDPS) DMF30HL MT DTT DMF30HL MA Inhibitor DMF30HL RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMF30HL RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DMWDEFC DI DMWDEFC DMWDEFC DN Zatosetron maleate DMWDEFC MI TTNXLKE DMWDEFC MN 5-HT 3 receptor (5HT3R) DMWDEFC MT DTT DMWDEFC MA Modulator DMWDEFC RN Pilot study of zatosetron (LY277359) maleate, a 5-hydroxytryptamine-3 antagonist, in the treatment of anxiety. J Clin Psychopharmacol. 1999 Apr;19(2):125-31. DMWDEFC RU https://www.ncbi.nlm.nih.gov/pubmed/10211913 DMP8ESD DI DMP8ESD DMP8ESD DN Zicronapine DMP8ESD MI TTJQOD7 DMP8ESD MN 5-HT 2A receptor (HTR2A) DMP8ESD MT DTT DMP8ESD MA Modulator DMP8ESD RN Clinical pipeline report, company report or official report of Lundbeck. DMP8ESD RU http://investor.lundbeck.com/releasedetail.cfm?ReleaseID=608605 DMP8ESD DI DMP8ESD DMP8ESD DN Zicronapine DMP8ESD MI TTZFYLI DMP8ESD MN Dopamine D1 receptor (D1R) DMP8ESD MT DTT DMP8ESD MA Modulator DMP8ESD RN Clinical pipeline report, company report or official report of Lundbeck. DMP8ESD RU http://investor.lundbeck.com/releasedetail.cfm?ReleaseID=608605 DMP8ESD DI DMP8ESD DMP8ESD DN Zicronapine DMP8ESD MI TTEX248 DMP8ESD MN Dopamine D2 receptor (D2R) DMP8ESD MT DTT DMP8ESD MA Modulator DMP8ESD RN Clinical pipeline report, company report or official report of Lundbeck. DMP8ESD RU http://investor.lundbeck.com/releasedetail.cfm?ReleaseID=608605 DM09TVB DI DM09TVB DM09TVB DN Zimura DM09TVB MI TTKANGO DM09TVB MN Complement C5 (CO5) DM09TVB MT DTT DM09TVB MA Inhibitor DM09TVB RN C5 Inhibitor Avacincaptad Pegol for Geographic Atrophy Due to Age-Related Macular Degeneration: A Randomized Pivotal Phase 2/3 Trial. Ophthalmology. 2021 Apr;128(4):576-586. DM09TVB RU https://pubmed.ncbi.nlm.nih.gov/32882310 DMFWMKZ DI DMFWMKZ DMFWMKZ DN ZK-93423 DMFWMKZ MI TT1MPAY DMFWMKZ MN GABA(A) receptor alpha-1 (GABRA1) DMFWMKZ MT DTT DMFWMKZ MA Inhibitor DMFWMKZ RN Structural requirements for agonist actions at the benzodiazepine receptor: studies with analogues of 6-(benzyloxy)-4-(methoxymethyl)-beta-carbolin... J Med Chem. 1990 Mar;33(3):1062-9. DMFWMKZ RU https://pubmed.ncbi.nlm.nih.gov/1968513 DMFWMKZ DI DMFWMKZ DMFWMKZ DN ZK-93423 DMFWMKZ MI TTZA1NY DMFWMKZ MN GABA(A) receptor beta-2 (GABRB2) DMFWMKZ MT DTT DMFWMKZ MA Inhibitor DMFWMKZ RN Structural requirements for agonist actions at the benzodiazepine receptor: studies with analogues of 6-(benzyloxy)-4-(methoxymethyl)-beta-carbolin... J Med Chem. 1990 Mar;33(3):1062-9. DMFWMKZ RU https://pubmed.ncbi.nlm.nih.gov/1968513 DMFWMKZ DI DMFWMKZ DMFWMKZ DN ZK-93423 DMFWMKZ MI TT06RH5 DMFWMKZ MN GABA(A) receptor gamma-2 (GABRG2) DMFWMKZ MT DTT DMFWMKZ MA Inhibitor DMFWMKZ RN Structural requirements for agonist actions at the benzodiazepine receptor: studies with analogues of 6-(benzyloxy)-4-(methoxymethyl)-beta-carbolin... J Med Chem. 1990 Mar;33(3):1062-9. DMFWMKZ RU https://pubmed.ncbi.nlm.nih.gov/1968513 DMFWMKZ DI DMFWMKZ DMFWMKZ DN ZK-93423 DMFWMKZ MI TTNJYV2 DMFWMKZ MN Gamma-aminobutyric acid receptor (GAR) DMFWMKZ MT DTT DMFWMKZ MA Inhibitor DMFWMKZ RN Structural requirements for agonist actions at the benzodiazepine receptor: studies with analogues of 6-(benzyloxy)-4-(methoxymethyl)-beta-carbolin... J Med Chem. 1990 Mar;33(3):1062-9. DMFWMKZ RU https://pubmed.ncbi.nlm.nih.gov/1968513 DM5ST9Z DI DM5ST9Z DM5ST9Z DN Zolbetuximab DM5ST9Z MI TT6PKBX DM5ST9Z MN Claudin-18 (CLDN18) DM5ST9Z MT DTT DM5ST9Z RN FAST: a randomised phase II study of zolbetuximab (IMAB362) plus EOX versus EOX alone for first-line treatment of advanced CLDN18.2-positive gastric and gastro-oesophageal adenocarcinoma. Ann Oncol. 2021 May;32(5):609-619. DM5ST9Z RU https://pubmed.ncbi.nlm.nih.gov/33610734 DM8L7JD DI DM8L7JD DM8L7JD DN Zoniporide hydrochloride DM8L7JD MI TTGSEFH DM8L7JD MN Sodium/hydrogen exchanger 1 (SLC9A1) DM8L7JD MT DTT DM8L7JD MA Inhibitor DM8L7JD RN Zoniporde: a potent and selective inhibitor of the human sodium-hydrogen exchanger isoform 1 (NHE-1). Cardiovasc Drug Rev. 2003 Spring;21(1):17-32. DM8L7JD RU https://pubmed.ncbi.nlm.nih.gov/12595915 DMMBJYC DI DMMBJYC DMMBJYC DN ZYH-1 DMMBJYC MI TTJ584C DMMBJYC MN Peroxisome proliferator-activated receptor alpha (PPARA) DMMBJYC MT DTT DMMBJYC MA Modulator DMMBJYC RN Pharmacokinetics, safety, and tolerability of saroglitazar (ZYH1), a predominantly PPARalpha agonist with moderate PPARgamma agonist activity in healthy human subjects. Clin Drug Investig. 2013 Nov;33(11):809-16. DMMBJYC RU https://pubmed.ncbi.nlm.nih.gov/24062180 DMMBJYC DI DMMBJYC DMMBJYC DN ZYH-1 DMMBJYC MI TTZMAO3 DMMBJYC MN Peroxisome proliferator-activated receptor gamma (PPAR-gamma) DMMBJYC MT DTT DMMBJYC MA Modulator DMMBJYC RN Pharmacokinetics, safety, and tolerability of saroglitazar (ZYH1), a predominantly PPARalpha agonist with moderate PPARgamma agonist activity in healthy human subjects. Clin Drug Investig. 2013 Nov;33(11):809-16. DMMBJYC RU https://pubmed.ncbi.nlm.nih.gov/24062180 DM12UX6 DI DM12UX6 DM12UX6 DN 131 I-omburtamab DM12UX6 MI TT6CQUM DM12UX6 MN B7 homolog 3 (CD276) DM12UX6 MT DTT DM12UX6 MA Inhibitor DM12UX6 RN IntraOmmaya compartmental radioimmunotherapy using 131 I-omburtamab-pharmacokinetic modeling to optimize therapeutic index. Eur J Nucl Med Mol Imaging. 2021 Apr;48(4):1166-1177. DM12UX6 RU https://pubmed.ncbi.nlm.nih.gov/33047248 DMZ0T24 DI DMZ0T24 DMZ0T24 DN Abagovomab DMZ0T24 MI TTC1PS3 DMZ0T24 MN Ovarian carcinoma antigen CA125 (MUC16) DMZ0T24 MT DTT DMZ0T24 RN Abagovomab: an anti-idiotypic CA-125 targeted immunotherapeutic agent for ovarian cancer. Immunotherapy. 2011 Feb;3(2):153-62. DMZ0T24 RU https://pubmed.ncbi.nlm.nih.gov/21322756 DMKY9GI DI DMKY9GI DMKY9GI DN Activated recombinant FVII-albumin fusion protein DMKY9GI MI TTF0EGX DMKY9GI MN Coagulation factor VII (F7) DMKY9GI MT DTT DMKY9GI MA Modulator DMKY9GI RN ClinicalTrials.gov (NCT01542619) A Safety and Pharmacokinetics Study of a Recombinant Fusion Protein Linking Coagulation Factor VIIa With Albumin (rVIIa-FP) in Healthy Male Volunteers. U.S. National Institutes of Health. DMKY9GI RU https://clinicaltrials.gov/ct2/show/NCT01542619 DMKY9GI DI DMKY9GI DMKY9GI DN Activated recombinant FVII-albumin fusion protein DMKY9GI MI TTFNGC9 DMKY9GI MN Serum albumin (ALB) DMKY9GI MT DTT DMKY9GI MA Modulator DMKY9GI RN ClinicalTrials.gov (NCT01542619) A Safety and Pharmacokinetics Study of a Recombinant Fusion Protein Linking Coagulation Factor VIIa With Albumin (rVIIa-FP) in Healthy Male Volunteers. U.S. National Institutes of Health. DMKY9GI RU https://clinicaltrials.gov/ct2/show/NCT01542619 DM6GTMD DI DM6GTMD DM6GTMD DN ADX-48621 DM6GTMD MI TTHS256 DM6GTMD MN Metabotropic glutamate receptor 5 (mGluR5) DM6GTMD MT DTT DM6GTMD MA Modulator DM6GTMD RN Pipeline of Addex Pharma. Addex Pharma. 2009. DM6GTMD RU http://www.addexpharma.com/pipeline-old/adx48621/ DMMHSLC DI DMMHSLC DMMHSLC DN Afq056 DMMHSLC MI DE6OQ3W DMMHSLC MN Cytochrome P450 1A1 (CYP1A1) DMMHSLC MT DME DMMHSLC MA Metabolism DMMHSLC RN Methods to Assess Pulmonary Metabolism. DMMHSLC RU https://edoc.unibas.ch/69409/1/110219_Doctoral_Thesis_Yildiz_Yilmaz.pdf DMMHSLC DI DMMHSLC DMMHSLC DN Afq056 DMMHSLC MI TTHS256 DMMHSLC MN Metabotropic glutamate receptor 5 (mGluR5) DMMHSLC MT DTT DMMHSLC MA Modulator DMMHSLC RN Metabolism and disposition of the metabotropic glutamate receptor 5 antagonist (mGluR5) mavoglurant (AFQ056) in healthy subjects. Drug Metab Dispos. 2013 Sep;41(9):1626-41. DMMHSLC RU https://pubmed.ncbi.nlm.nih.gov/23775850 DMGC970 DI DMGC970 DMGC970 DN AG-013 DMGC970 MI TTNOJIZ DMGC970 MN Trefoil factor-1 (TFF1) DMGC970 MT DTT DMGC970 MA Modulator DMGC970 RN AG013, a mouth rinse formulation of Lactococcus lactis secreting human Trefoil Factor 1, provides a safe and efficacious therapeutic tool for treating oral mucositis. Oral Oncol. 2010 Jul;46(7):564-70. DMGC970 RU https://pubmed.ncbi.nlm.nih.gov/20542722 DMD741P DI DMD741P DMD741P DN Alagebrium chloride DMD741P MI TTMO9HF DMD741P MN Advanced glycosylation end product receptor (AGER) DMD741P MT DTT DMD741P MA Breaker DMD741P RN Effect of the age cross-link breaker alagebrium on anterior segment physiology, morphology, and ocular age and rage. Trans Am Ophthalmol Soc. 2009 Dec;107:146-58. DMD741P RU https://pubmed.ncbi.nlm.nih.gov/20126491 DM36HBS DI DM36HBS DM36HBS DN ALXN1101 DM36HBS MI TTH13AB DM36HBS MN Cyclic pyranopterin monophosphate synthase (MOCS1) DM36HBS MT DTT DM36HBS MA Modulator DM36HBS RN ClinicalTrials.gov (NCT02047461) Safety & Efficacy Study of ALXN1101 in Pediatric Patients With MoCD Type A Currently Treated With rcPMP. U.S. National Institutes of Health. DM36HBS RU https://clinicaltrials.gov/ct2/show/NCT02047461 DMBFOAZ DI DMBFOAZ DMBFOAZ DN AMG520 DMBFOAZ MI TTJUNZF DMBFOAZ MN Beta-secretase 1 (BACE1) DMBFOAZ MT DTT DMBFOAZ MA Inhibitor DMBFOAZ RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMBFOAZ RU http://phrma-docs.phrma.org/files/dmfile/MID-Update_Alzheimers-Disease_2017-Drug-List.pdf DMN6F1W DI DMN6F1W DMN6F1W DN Amiodarone DMN6F1W MI TTHQJ2Y DMN6F1W MN HUMAN two pore channel subtype 2 (TPC2) DMN6F1W MT DTT DMN6F1W MA Blocker DMN6F1W RN Characterization of spike glycoprotein of SARS-CoV-2 on virus entry and its immune cross-reactivity with SARS-CoV. Nat Commun. 2020 Mar 27;11(1):1620. DMN6F1W RU https://pubmed.ncbi.nlm.nih.gov/32221306 DMJRU3A DI DMJRU3A DMJRU3A DN AMO-02 DMJRU3A MI TTRSMW9 DMJRU3A MN Glycogen synthase kinase-3 beta (GSK-3B) DMJRU3A MT DTT DMJRU3A MA Inhibitor DMJRU3A RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMJRU3A RU http://phrma-docs.phrma.org/files/dmfile/MID_Neurological-Disorders-Drug-List_2018.pdf DMDLGRO DI DMDLGRO DMDLGRO DN Aramchol DMDLGRO MI TT6RIOV DMDLGRO MN Acyl-CoA desaturase (SCD) DMDLGRO MT DTT DMDLGRO MA Inhibitor DMDLGRO RN The fatty acid-bile acid conjugate Aramchol reduces liver fat content in patients with nonalcoholic fatty liver disease. Clin Gastroenterol Hepatol. 2014 Dec;12(12):2085-91.e1. DMDLGRO RU https://pubmed.ncbi.nlm.nih.gov/24815326 DMS8QF9 DI DMS8QF9 DMS8QF9 DN Arimoclomol DMS8QF9 MI TTG91S4 DMS8QF9 MN Heat shock protein (HSP) DMS8QF9 MT DTT DMS8QF9 MA Modulator DMS8QF9 RN Arimoclomol, a coinducer of heat shock proteins for the potential treatment of amyotrophic lateral sclerosis. IDrugs. 2010 Jul;13(7):482-96. DMS8QF9 RU https://pubmed.ncbi.nlm.nih.gov/20582873 DM15VBJ DI DM15VBJ DM15VBJ DN Artemisone DM15VBJ MI TT9X7H4 DM15VBJ MN Beta-hematin formation (BHF) DM15VBJ MT DTT DM15VBJ MA Modulator DM15VBJ RN Anticancer Properties of Distinct Antimalarial Drug Classes. PLoS One. 2013; 8(12): e82962. DM15VBJ RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3877007/ DMZGKXW DI DMZGKXW DMZGKXW DN Atogepant DMZGKXW MI TTQ4ESF DMZGKXW MN Calgranulin D (S100A12) DMZGKXW MT DTT DMZGKXW MA Antagonist DMZGKXW RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMZGKXW RU http://phrma-docs.phrma.org/files/dmfile/MID_Neurological-Disorders-Drug-List_2018.pdf DMVB4OS DI DMVB4OS DMVB4OS DN AVN 211 DMVB4OS MI TTJS8PY DMVB4OS MN 5-HT 6 receptor (HTR6) DMVB4OS MT DTT DMVB4OS MA Modulator DMVB4OS RN Latrepirdine, a potential novel treatment for Alzheimer's disease and Huntington's chorea. Curr Opin Investig Drugs. 2010 January; 11(1): 80-91. DMVB4OS RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3346261/ DM5YHU2 DI DM5YHU2 DM5YHU2 DN Avoralstat DM5YHU2 MI TTDJ4MY DM5YHU2 MN Kininogen (KNG1) DM5YHU2 MT DTT DM5YHU2 MA Inhibitor DM5YHU2 RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DM5YHU2 RU http://phrma-docs.phrma.org/sites/default/files/pdf/medicines-in-development-drug-list-rare-diseases.pdf DM5YHU2 DI DM5YHU2 DM5YHU2 DN Avoralstat DM5YHU2 MI TTJLNAW DM5YHU2 MN Tissue kallikrein (KLK2) DM5YHU2 MT DTT DM5YHU2 MA Inhibitor DM5YHU2 RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DM5YHU2 RU http://phrma-docs.phrma.org/sites/default/files/pdf/medicines-in-development-drug-list-rare-diseases.pdf DMJQHXD DI DMJQHXD DMJQHXD DN AZD3293 DMJQHXD MI TT8JRS7 DMJQHXD MN Beta-secretase (BACE) DMJQHXD MT DTT DMJQHXD MA Modulator DMJQHXD RN AZD3293 A novel BACE1 inhibitor: safety, tolerability, and effects on plasma and CSF A-beta peptides following single- and multiple-dose administration. Neurobiology of Aging. May 20, 2008. DMJQHXD RU http://www.neurobiologyofaging.org/article/S0197-4580(08)00131-0/abstract DM3827C DI DM3827C DM3827C DN AZD4547 DM3827C MI TT0LF7H DM3827C MN Fibroblast growth factor receptor (FGFR) DM3827C MT DTT DM3827C MA Inhibitor DM3827C RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DM3827C RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DM3827C DI DM3827C DM3827C DN AZD4547 DM3827C MI TTRLW2X DM3827C MN Fibroblast growth factor receptor 1 (FGFR1) DM3827C MT DTT DM3827C MA Modulator DM3827C RN AZD4547: an orally bioavailable, potent, and selective inhibitor of the fibroblast growth factor receptor tyrosine kinase family. Cancer Res. 2012 Apr 15;72(8):2045-56. DM3827C RU https://pubmed.ncbi.nlm.nih.gov/22369928 DMHWE5R DI DMHWE5R DMHWE5R DN Batabulin DMHWE5R MI TTYFKSZ DMHWE5R MN Tubulin beta (TUBB) DMHWE5R MT DTT DMHWE5R MA Inhibitor DMHWE5R RN Hydrophilic, pro-drug analogues of T138067 are efficacious in controlling tumor growth in vivo and show a decreased ability to cross the blood brain barrier. J Med Chem. 2001 Oct 25;44(22):3599-605. DMHWE5R RU https://pubmed.ncbi.nlm.nih.gov/11606124 DMKT16N DI DMKT16N DMKT16N DN Bevacizumab DMKT16N MI TT140V6 DMKT16N MN HUMAN vascular endothelial growth factor (VEGF) DMKT16N MT DTT DMKT16N MA Inhibitor DMKT16N RN ClinicalTrials.gov (NCT04275414) Bevacizumab in Severe or Critical Patients With COVID-19 Pneumonia (BEST-CP) DMKT16N RU https://clinicaltrials.gov/ct2/show/NCT04275414 DMUSJ3D DI DMUSJ3D DMUSJ3D DN BIIB-088 DMUSJ3D MI TTHBDA9 DMUSJ3D MN X-linked retinitis pigmentosa GTPase regulator (RPGR) DMUSJ3D MT DTT DMUSJ3D RN ClinicalTrials.gov (NCT04850118) A Clinical Trial Evaluating the Safety and Efficacy of a Single Subretinal Injection of AGTC-501 in Participants With X-linked Retinitis Pigmentosa Caused by RPGR Mutations. U.S. National Institutes of Health. DMUSJ3D RU https://clinicaltrials.gov/ct2/show/NCT04850118 DMYFQJL DI DMYFQJL DMYFQJL DN BNV-222 DMYFQJL MI TTFBNVI DMYFQJL MN Aldose reductase (AKR1B1) DMYFQJL MT DTT DMYFQJL MA Inhibitor DMYFQJL RN ClinicalTrials.gov (NCT02332005) 12-Month Efficacy and Safety of Diepalrestat in Adults With Diabetic Peripheral Neuropathy, a DB, Placebo-Controlled Study (DE-DPN). U.S. National Institutes of Health. DMYFQJL RU https://clinicaltrials.gov/ct2/show/NCT02332005 DMV52CP DI DMV52CP DMV52CP DN Bucindolol DMV52CP MI TTR6W5O DMV52CP MN Adrenergic receptor beta-1 (ADRB1) DMV52CP MT DTT DMV52CP MA Modulator DMV52CP RN Bucindolol has serotonin and alpha-adrenoceptor blocking properties. J Cardiovasc Pharmacol. 1985;7 Suppl 7:S67-9. DMV52CP RU https://www.ncbi.nlm.nih.gov/pubmed/2412063 DMV52CP DI DMV52CP DMV52CP DN Bucindolol DMV52CP MI TT2CJVK DMV52CP MN Adrenergic receptor beta-2 (ADRB2) DMV52CP MT DTT DMV52CP MA Modulator DMV52CP RN Bucindolol has serotonin and alpha-adrenoceptor blocking properties. J Cardiovasc Pharmacol. 1985;7 Suppl 7:S67-9. DMV52CP RU https://www.ncbi.nlm.nih.gov/pubmed/2412063 DMV52CP DI DMV52CP DMV52CP DN Bucindolol DMV52CP MI DECB0K3 DMV52CP MN Cytochrome P450 2D6 (CYP2D6) DMV52CP MT DME DMV52CP MA Metabolism DMV52CP RN Application of substrate depletion assay to evaluation of CYP isoforms responsible for stereoselective metabolism of carvedilol. Drug Metab Pharmacokinet. 2016 Dec;31(6):425-432. DMV52CP RU https://www.ncbi.nlm.nih.gov/pubmed/?term=27836712 DM31VZT DI DM31VZT DM31VZT DN CAD-106 DM31VZT MI TTE4KHA DM31VZT MN Amyloid beta A4 protein (APP) DM31VZT MT DTT DM31VZT RN The second-generation active Abeta immunotherapy CAD106 reduces amyloid accumulation in APP transgenic mice while minimizing potential side effects. J Neurosci. 2011 Jun 22;31(25):9323-31. DM31VZT RU https://pubmed.ncbi.nlm.nih.gov/21697382 DMVLXMG DI DMVLXMG DMVLXMG DN Camostat mesylate DMVLXMG MI TT3FDB1 DMVLXMG MN HUMAN transmembrane protease serine 2 (TMPRSS2) DMVLXMG MT DTT DMVLXMG MA Inhibitor DMVLXMG RN SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor. Cell. 2020 Apr 16;181(2):271-280.e8. DMVLXMG RU https://pubmed.ncbi.nlm.nih.gov/32142651 DMST3FM DI DMST3FM DMST3FM DN CART-19 DMST3FM MI TTW640A DMST3FM MN B-lymphocyte surface antigen B4 (CD19) DMST3FM MT DTT DMST3FM MA CAR-T-Cell-Therapy DMST3FM RN ClinicalTrials.gov (NCT03027739) CART-19 Cells For MRD Positive CD19+ ALL DMST3FM RU https://clinicaltrials.gov/ct2/show/NCT03027739 DM45Z3P DI DM45Z3P DM45Z3P DN CD123/CLL1 CAR-T Cells DM45Z3P MI TTENHJ0 DM45Z3P MN Interleukin 3 receptor alpha (IL3RA) DM45Z3P MT DTT DM45Z3P MA CAR-T-Cell-Therapy(Dual specific) DM45Z3P RN ClinicalTrials.gov (NCT03631576) CD123/CLL1 CAR-T Cells for R/R AML DM45Z3P RU https://clinicaltrials.gov/ct2/show/NCT03631576 DM45Z3P DI DM45Z3P DM45Z3P DN CD123/CLL1 CAR-T Cells DM45Z3P MI TT70N8V DM45Z3P MN Myeloid inhibitory C-type lectin-like receptor (CD371) DM45Z3P MT DTT DM45Z3P MA CAR-T-Cell-Therapy(Dual specific) DM45Z3P RN ClinicalTrials.gov (NCT03631576) CD123/CLL1 CAR-T Cells for R/R AML DM45Z3P RU https://clinicaltrials.gov/ct2/show/NCT03631576 DM32148 DI DM32148 DM32148 DN CD19 CAR T cells DM32148 MI TTW640A DM32148 MN B-lymphocyte surface antigen B4 (CD19) DM32148 MT DTT DM32148 MA CAR-T-Cell-Therapy DM32148 RN ClinicalTrials.gov (NCT03391726) CART-19 Cells for R/R B-cell Lymphoma DM32148 RU https://clinicaltrials.gov/ct2/show/NCT03391726 DMFCLT6 DI DMFCLT6 DMFCLT6 DN CE-224535 DMFCLT6 MI TT473XN DMFCLT6 MN P2X purinoceptor 7 (P2RX7) DMFCLT6 MT DTT DMFCLT6 MA Antagonist DMFCLT6 RN Efficacy and safety of CE-224,535, an antagonist of P2X7 receptor, in treatment of patients with rheumatoid arthritis inadequately controlled by methotrexate. J Rheumatol. 2012 Apr;39(4):720-7. DMFCLT6 RU https://pubmed.ncbi.nlm.nih.gov/22382341 DMXCD69 DI DMXCD69 DMXCD69 DN CEP1347 DMXCD69 MI TTUNSIX DMXCD69 MN Mixed lineage kinase 1 (MAP3K9) DMXCD69 MT DTT DMXCD69 MA Inhibitor DMXCD69 RN Pharmacological inhibitors of MAPK pathways. Trends Pharmacol Sci. 2002 Jan;23(1):40-5. DMXCD69 RU https://pubmed.ncbi.nlm.nih.gov/11804650 DMUOMBZ DI DMUOMBZ DMUOMBZ DN CLL1 CAR-T Cell DMUOMBZ MI TT70N8V DMUOMBZ MN Myeloid inhibitory C-type lectin-like receptor (CD371) DMUOMBZ MT DTT DMUOMBZ MA CAR-T-Cell-Therapy(Dual specific) DMUOMBZ RN ClinicalTrials.gov (NCT03631576) CD123/CLL1 CAR-T Cells for R/R AML DMUOMBZ RU https://clinicaltrials.gov/ct2/show/NCT03631576 DMX9V8K DI DMX9V8K DMX9V8K DN Contigoside B DMX9V8K MI TTFBNVI DMX9V8K MN Aldose reductase (AKR1B1) DMX9V8K MT DTT DMX9V8K MA Inhibitor DMX9V8K RN Effect of Polygonum hydropiper sulfated flavonoids on lens aldose reductase and related enzymes. J Nat Prod. 1996 Apr;59(4):443-5. DMX9V8K RU https://pubmed.ncbi.nlm.nih.gov/8699190 DMX9V8K DI DMX9V8K DMX9V8K DN Contigoside B DMX9V8K MI TTL69WB DMX9V8K MN Angiotensin-converting enzyme (ACE) DMX9V8K MT DTT DMX9V8K MA Inhibitor DMX9V8K RN Inhibitory effects of various flavonoids isolated from leaves of persimmon on angiotensin-converting enzyme activity. J Nat Prod. 1987 Jul-Aug;50(4):680-3. DMX9V8K RU https://pubmed.ncbi.nlm.nih.gov/3430165 DMX9V8K DI DMX9V8K DMX9V8K DN Contigoside B DMX9V8K MI DEXLYGD DMX9V8K MN Beta-glucosidase (bglA) DMX9V8K MT DME DMX9V8K MA Metabolism DMX9V8K RN Identification of rutin deglycosylated metabolites produced by human intestinal bacteria using UPLC-Q-TOF/MS. J Chromatogr B Analyt Technol Biomed Life Sci. 2012 Jun 1;898:95-100. DMX9V8K RU https://pubmed.ncbi.nlm.nih.gov/22583754 DMX9V8K DI DMX9V8K DMX9V8K DN Contigoside B DMX9V8K MI DEZXOEW DMX9V8K MN Beta-glucosidase (bglA) DMX9V8K MT DME DMX9V8K MA Metabolism DMX9V8K RN Identification of rutin deglycosylated metabolites produced by human intestinal bacteria using UPLC-Q-TOF/MS. J Chromatogr B Analyt Technol Biomed Life Sci. 2012 Jun 1;898:95-100. DMX9V8K RU https://pubmed.ncbi.nlm.nih.gov/22583754 DMX9V8K DI DMX9V8K DMX9V8K DN Contigoside B DMX9V8K MI DE4WCJL DMX9V8K MN Beta-glucosidase (bglA) DMX9V8K MT DME DMX9V8K MA Metabolism DMX9V8K RN Identification of rutin deglycosylated metabolites produced by human intestinal bacteria using UPLC-Q-TOF/MS. J Chromatogr B Analyt Technol Biomed Life Sci. 2012 Jun 1;898:95-100. DMX9V8K RU https://pubmed.ncbi.nlm.nih.gov/22583754 DMJYTUQ DI DMJYTUQ DMJYTUQ DN CR-845 DMJYTUQ MI TTQW87Y DMJYTUQ MN Opioid receptor kappa (OPRK1) DMJYTUQ MT DTT DMJYTUQ MA Agonist DMJYTUQ RN Peptide Kappa Opioid Receptor Ligands: Potential for Drug Development. AAPS J. 2009 June; 11(2): 312-322. DMJYTUQ RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2691465/ DMSR7D2 DI DMSR7D2 DMSR7D2 DN CX-516 DMSR7D2 MI TTAN6JD DMSR7D2 MN Glutamate receptor AMPA (GRIA) DMSR7D2 MT DTT DMSR7D2 MA Modulator DMSR7D2 RN Autism spectrum disorders: emerging pharmacotherapy. Expert Opin Emerg Drugs. 2005 Aug;10(3):521-36. DMSR7D2 RU https://pubmed.ncbi.nlm.nih.gov/16083327 DML906E DI DML906E DML906E DN CY-1503 DML906E MI TTAU4D6 DML906E MN E-selectin (SELE) DML906E MT DTT DML906E MA Modulator DML906E RN Adjunctive selectin blockade successfully reduces infarct size beyond thrombolysis in the electrolytic canine coronary artery model. Circulation. 1995 Aug 1;92(3):492-9. DML906E RU https://pubmed.ncbi.nlm.nih.gov/7543381 DML906E DI DML906E DML906E DN CY-1503 DML906E MI TTE5VG0 DML906E MN P-selectin (SELP) DML906E MT DTT DML906E MA Modulator DML906E RN Adjunctive selectin blockade successfully reduces infarct size beyond thrombolysis in the electrolytic canine coronary artery model. Circulation. 1995 Aug 1;92(3):492-9. DML906E RU https://pubmed.ncbi.nlm.nih.gov/7543381 DMYVKM5 DI DMYVKM5 DMYVKM5 DN Darbufelone DMYVKM5 MI TT2J34L DMYVKM5 MN Arachidonate 5-lipoxygenase (5-LOX) DMYVKM5 MT DTT DMYVKM5 MA Modulator DMYVKM5 RN Novel dual cyclooxygenase and lipoxygenase inhibitors targeting hyaluronan-CD44v6 pathway and inducing cytotoxicity in colon cancer cells. Bioorg Med Chem. 2013 May 1;21(9):2551-9. DMYVKM5 RU https://pubmed.ncbi.nlm.nih.gov/23517721 DMYVKM5 DI DMYVKM5 DMYVKM5 DN Darbufelone DMYVKM5 MI TTVKILB DMYVKM5 MN Prostaglandin G/H synthase 2 (COX-2) DMYVKM5 MT DTT DMYVKM5 MA Modulator DMYVKM5 RN Novel dual cyclooxygenase and lipoxygenase inhibitors targeting hyaluronan-CD44v6 pathway and inducing cytotoxicity in colon cancer cells. Bioorg Med Chem. 2013 May 1;21(9):2551-9. DMYVKM5 RU https://pubmed.ncbi.nlm.nih.gov/23517721 DMZV3SY DI DMZV3SY DMZV3SY DN Denagliptin DMZV3SY MI TTDIGC1 DMZV3SY MN Dipeptidyl peptidase 4 (DPP-4) DMZV3SY MT DTT DMZV3SY MA Inhibitor DMZV3SY RN Emerging drug candidates of dipeptidyl peptidase IV (DPP IV) inhibitor class for the treatment of Type 2 Diabetes. Curr Drug Targets. 2009 Jan;10(1):71-87. DMZV3SY RU https://pubmed.ncbi.nlm.nih.gov/19149538 DMVSIN2 DI DMVSIN2 DMVSIN2 DN Emapalumab DMVSIN2 MI TTR10KI DMVSIN2 MN HUMAN interferon gamma (IFNG) DMVSIN2 MT DTT DMVSIN2 MA Inhibitor DMVSIN2 RN Interferon-beta and interferon-gamma synergistically inhibit the replication of severe acute respiratory syndrome-associated coronavirus (SARS-CoV). Virology. 2004 Nov 10;329(1):11-7. doi: 10.1016/j.virol.2004.08.011. DMVSIN2 RU https://pubmed.ncbi.nlm.nih.gov/15476870 DMH8VMP DI DMH8VMP DMH8VMP DN Emixustat DMH8VMP MI TTBOH16 DMH8VMP MN Retinal pigment epithelium protein (RPE65) DMH8VMP MT DTT DMH8VMP MA Inhibitor DMH8VMP RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMH8VMP RU http://phrma-docs.phrma.org/files/dmfile/mid-diabetes-drug-list.pdf DMOYE70 DI DMOYE70 DMOYE70 DN Fexinidazole DMOYE70 MI DEJGDUW DMOYE70 MN Cytochrome P450 1A2 (CYP1A2) DMOYE70 MT DME DMOYE70 MA Metabolism DMOYE70 RN Fexinidazole--a new oral nitroimidazole drug candidate entering clinical development for the treatment of sleeping sickness. PLoS Negl Trop Dis. 2010 Dec 21;4(12):e923. DMOYE70 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=21200426 DMOYE70 DI DMOYE70 DMOYE70 DN Fexinidazole DMOYE70 MI DEPKLMQ DMOYE70 MN Cytochrome P450 2B6 (CYP2B6) DMOYE70 MT DME DMOYE70 MA Metabolism DMOYE70 RN Fexinidazole--a new oral nitroimidazole drug candidate entering clinical development for the treatment of sleeping sickness. PLoS Negl Trop Dis. 2010 Dec 21;4(12):e923. DMOYE70 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=21200426 DMOYE70 DI DMOYE70 DMOYE70 DN Fexinidazole DMOYE70 MI DECB0K3 DMOYE70 MN Cytochrome P450 2D6 (CYP2D6) DMOYE70 MT DME DMOYE70 MA Metabolism DMOYE70 RN Fexinidazole--a new oral nitroimidazole drug candidate entering clinical development for the treatment of sleeping sickness. PLoS Negl Trop Dis. 2010 Dec 21;4(12):e923. DMOYE70 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=21200426 DMOYE70 DI DMOYE70 DMOYE70 DN Fexinidazole DMOYE70 MI DE4LYSA DMOYE70 MN Cytochrome P450 3A4 (CYP3A4) DMOYE70 MT DME DMOYE70 MA Metabolism DMOYE70 RN Fexinidazole--a new oral nitroimidazole drug candidate entering clinical development for the treatment of sleeping sickness. PLoS Negl Trop Dis. 2010 Dec 21;4(12):e923. DMOYE70 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=21200426 DMOYE70 DI DMOYE70 DMOYE70 DN Fexinidazole DMOYE70 MI DEIBDNY DMOYE70 MN Cytochrome P450 3A5 (CYP3A5) DMOYE70 MT DME DMOYE70 MA Metabolism DMOYE70 RN Fexinidazole--a new oral nitroimidazole drug candidate entering clinical development for the treatment of sleeping sickness. PLoS Negl Trop Dis. 2010 Dec 21;4(12):e923. DMOYE70 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=21200426 DMOYE70 DI DMOYE70 DMOYE70 DN Fexinidazole DMOYE70 MI DEGTFWK DMOYE70 MN Mephenytoin 4-hydroxylase (CYP2C19) DMOYE70 MT DME DMOYE70 MA Metabolism DMOYE70 RN Fexinidazole--a new oral nitroimidazole drug candidate entering clinical development for the treatment of sleeping sickness. PLoS Negl Trop Dis. 2010 Dec 21;4(12):e923. DMOYE70 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=21200426 DMH7CSQ DI DMH7CSQ DMH7CSQ DN Gavilimomab DMH7CSQ MI TT5UJWD DMH7CSQ MN Basigin (BSG) DMH7CSQ MT DTT DMH7CSQ RN National Cancer Institute Drug Dictionary (drug id 38221). DMH7CSQ RU http://www.cancer.gov/publications/dictionaries/cancer-drug?cdrid=38221 DM0JETC DI DM0JETC DM0JETC DN Genistein DM0JETC MI DTI7UX6 DM0JETC MN Breast cancer resistance protein (ABCG2) DM0JETC MT DTP DM0JETC MA Substrate DM0JETC RN Differential selectivity of efflux transporter inhibitors in Caco-2 and MDCK-MDR1 monolayers: a strategy to assess the interaction of a new chemical entity with P-gp, BCRP, and MRP2. J Pharm Sci. 2012 May;101(5):1888-97. DM0JETC RU https://doi.org/10.1002/jps.23069 DM0JETC DI DM0JETC DM0JETC DN Genistein DM0JETC MI DEJGDUW DM0JETC MN Cytochrome P450 1A2 (CYP1A2) DM0JETC MT DME DM0JETC MA Metabolism DM0JETC RN Differential mechanisms for the inhibition of human cytochrome P450 1A2 by apigenin and genistein. J Biochem Mol Toxicol. 2010 Jul-Aug;24(4):230-4. DM0JETC RU https://www.ncbi.nlm.nih.gov/pubmed/?term=20806393 DM0JETC DI DM0JETC DM0JETC DN Genistein DM0JETC MI TTOM3J0 DM0JETC MN Estrogen receptor beta (ESR2) DM0JETC MT DTT DM0JETC MA Modulator DM0JETC RN Company report (Axcentua) DM0JETC RU http://axcentua.com/science/genistein/ DM0JETC DI DM0JETC DM0JETC DN Genistein DM0JETC MI DE0P6LK DM0JETC MN Sulfotransferase 2A1 (SULT2A1) DM0JETC MT DME DM0JETC MA Metabolism DM0JETC RN Sulfation of environmental estrogens by cytosolic human sulfotransferases. Drug Metab Pharmacokinet. 2002;17(3):221-8. DM0JETC RU https://www.ncbi.nlm.nih.gov/pubmed/?term=15618673 DMW7TZV DI DMW7TZV DMW7TZV DN GS-6207 DMW7TZV MI TTTWS2G DMW7TZV MN Human immunodeficiency virus Capsid p24 (HIV p24) DMW7TZV MT DTT DMW7TZV MA Inhibitor DMW7TZV RN Clinical pipeline report, company report or official report of Gilead Sciences. DMW7TZV RU https://www.gilead.com/science-and-medicine/pipeline DMMTL7V DI DMMTL7V DMMTL7V DN Hemoglobin raffimer DMMTL7V MI TTQO71U DMMTL7V MN Hemoglobin (HB) DMMTL7V MT DTT DMMTL7V MA Modulator DMMTL7V RN Use of hemoglobin raffimer for postoperative life-threatening anemia in a Jehovah's Witness. Can J Anaesth. 2005 Apr;52(4):369-73. DMMTL7V RU https://pubmed.ncbi.nlm.nih.gov/15814750 DMPLQ1V DI DMPLQ1V DMPLQ1V DN IFX-1 DMPLQ1V MI TTRJ91Q DMPLQ1V MN HUMAN complement C5 alpha (C5A) DMPLQ1V MT DTT DMPLQ1V MA Inhibitor DMPLQ1V RN 03-2020-InflaRx Doses First Patient in Multicenter Randomized Clinical Trial in Severe Progressed COVID-19 Pneumonia in Europe upon Receipt of Initial Positive Human Data with InflaRxs anti-C5a Technology DMPLQ1V RU https://www.inflarx.de/Home/Investors/Press-Releases/03-2020-InflaRx-Doses-First-Patient-in-Multicenter-Randomized-Clinical-Trial-in-Severe-Progressed-COVID-19-Pneumonia-in-Europe-upon-Receipt-of-Initial-Positive-Human-Data-with-InflaRx-s-anti-C5a-Technology.html DMONWJ4 DI DMONWJ4 DMONWJ4 DN Imetelstat DMONWJ4 MI TTUJFD0 DMONWJ4 MN Telomerase reverse transcriptase (TERT) DMONWJ4 MT DTT DMONWJ4 MA Inhibitor DMONWJ4 RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMONWJ4 RU http://phrma-docs.phrma.org/sites/default/files/pdf/medicines-in-development-drug-list-rare-diseases.pdf DMIUA3M DI DMIUA3M DMIUA3M DN Imprime PGG DMIUA3M MI TTJGY7A DMIUA3M MN Complement C3 (CO3) DMIUA3M MT DTT DMIUA3M MA Modulator DMIUA3M RN National Cancer Institute Drug Dictionary (drug id 599816). DMIUA3M RU http://www.cancer.gov/publications/dictionaries/cancer-drug?cdrid=599816 DM5UJ9P DI DM5UJ9P DM5UJ9P DN IMU-838 DM5UJ9P MI TT3UY29 DM5UJ9P MN HUMAN dihydroorotate dehydrogenase (DHODH) DM5UJ9P MT DTT DM5UJ9P MA Inhibitor DM5UJ9P RN IMU-838 Targeting DHODH DM5UJ9P RU https://www.immunic-therapeutics.com/imu838/ DMC3794 DI DMC3794 DMC3794 DN Indium-111 DMC3794 MI TTGKNB4 DMC3794 MN Epidermal growth factor receptor (EGFR) DMC3794 MT DTT DMC3794 RN Characterization of ABT-806, a Humanized Tumor-Specific Anti-EGFR Monoclonal Antibody. Mol Cancer Ther. 2015 May;14(5):1141-51. DMC3794 RU https://pubmed.ncbi.nlm.nih.gov/25731184 DMGPJ5U DI DMGPJ5U DMGPJ5U DN JNJ-54861911 DMGPJ5U MI TT8JRS7 DMGPJ5U MN Beta-secretase (BACE) DMGPJ5U MT DTT DMGPJ5U MA Inhibitor DMGPJ5U RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMGPJ5U RU http://phrma-docs.phrma.org/files/dmfile/MID_Neurological-Disorders-Drug-List_2018.pdf DMBJ4IZ DI DMBJ4IZ DMBJ4IZ DN LECOZOTAN HYDROCHLORIDE DMBJ4IZ MI TTSQIFT DMBJ4IZ MN 5-HT 1A receptor (HTR1A) DMBJ4IZ MT DTT DMBJ4IZ MA Antagonist DMBJ4IZ RN A positron emission tomography study to assess binding of lecozotan, a novel 5-hydroxytryptamine-1A silent antagonist, to brain 5-HT1A receptors in... Clin Pharmacol Ther. 2008 Jan;83(1):86-96. DMBJ4IZ RU https://pubmed.ncbi.nlm.nih.gov/17507923 DMEUGZL DI DMEUGZL DMEUGZL DN Legumain-cleavable doxorubicin prodrugs DMEUGZL MI TTPTWV5 DMEUGZL MN Legumain (LGMN) DMEUGZL MT DTT DMEUGZL MA Modulator DMEUGZL RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2380). DMEUGZL RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2380 DM4OYXE DI DM4OYXE DM4OYXE DN LIAROZOLE DM4OYXE MI TTSZLWK DM4OYXE MN Aromatase (CYP19A1) DM4OYXE MT DTT DM4OYXE MA Inhibitor DM4OYXE RN Pharmacophore modeling strategies for the development of novel nonsteroidal inhibitors of human aromatase (CYP19). Bioorg Med Chem Lett. 2010 May 15;20(10):3050-64. DM4OYXE RU https://pubmed.ncbi.nlm.nih.gov/20413308 DM4OYXE DI DM4OYXE DM4OYXE DN LIAROZOLE DM4OYXE MI TTD7Q0R DM4OYXE MN Cytochrome P450 26 (CYP26A1) DM4OYXE MT DTT DM4OYXE MA Inhibitor DM4OYXE RN Novel azolyl-(phenylmethyl)]aryl/heteroarylamines: potent CYP26 inhibitors and enhancers of all-trans retinoic acid activity in neuroblastoma cells. Bioorg Med Chem. 2008 Sep 1;16(17):8301-13. DM4OYXE RU https://pubmed.ncbi.nlm.nih.gov/18722776 DMI215P DI DMI215P DMI215P DN Lopinavir + ritonavir + interferon beta-1b DMI215P MI TTWOH4Q DMI215P MN MERS-CoV 3C-like proteinase (3CLpro) DMI215P MT DTT DMI215P MA Inhibitor DMI215P RN Coronavirus puts drug repurposing on the fast track. Nat Biotechnol. 2020 Apr;38(4):379-381. DMI215P RU https://pubmed.ncbi.nlm.nih.gov/32205870 DMP8HW1 DI DMP8HW1 DMP8HW1 DN LY2157299 DMP8HW1 MI TTP4520 DMP8HW1 MN TGF-beta receptor type I (TGFBR1) DMP8HW1 MT DTT DMP8HW1 MA Modulator DMP8HW1 RN Cardiac Safety of TGF-beta Receptor I Kinase Inhibitor LY2157299 Monohydrate in Cancer Patients in a First-in-Human Dose Study. Cardiovasc Toxicol. 2015 Oct;15(4):309-23. DMP8HW1 RU https://pubmed.ncbi.nlm.nih.gov/25488804 DMP8HW1 DI DMP8HW1 DMP8HW1 DN LY2157299 DMP8HW1 MI TTR9XHZ DMP8HW1 MN Transforming growth factor beta 1 (TGFB1) DMP8HW1 MT DTT DMP8HW1 MA Inhibitor DMP8HW1 RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMP8HW1 RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DMUQWRD DI DMUQWRD DMUQWRD DN LYS-SAF302 DMUQWRD MI TTPJ2SH DMUQWRD MN N-sulphoglucosamine sulphohydrolase (SGSH) DMUQWRD MT DTT DMUQWRD MA Replacement DMUQWRD RN Clinical pipeline report, company report or official report of Lysogene. DMUQWRD RU https://www.lysogene.com/lys-saf302/ DM948AP DI DM948AP DM948AP DN MAb114 DM948AP MI TT2F0AU DM948AP MN Ebola virus Envelope glycoprotein (EV GP) DM948AP MT DTT DM948AP RN Ansuvimab: First Approval. Drugs. 2021 Apr;81(5):595-598. DM948AP RU https://pubmed.ncbi.nlm.nih.gov/33751449 DMONYS9 DI DMONYS9 DMONYS9 DN MBX-102 DMONYS9 MI TTZMAO3 DMONYS9 MN Peroxisome proliferator-activated receptor gamma (PPAR-gamma) DMONYS9 MT DTT DMONYS9 MA Agonist DMONYS9 RN MBX-102/JNJ39659100, a novel peroxisome proliferator-activated receptor-ligand with weak transactivation activity retains antidiabetic properties in the absence of weight gain and edema. Mol Endocrinol. 2009 Jul;23(7):975-88. DMONYS9 RU https://pubmed.ncbi.nlm.nih.gov/19389808 DMNTCV4 DI DMNTCV4 DMNTCV4 DN MBX-8025 DMNTCV4 MI TT2JWF6 DMNTCV4 MN Peroxisome proliferator-activated receptor delta (PPARD) DMNTCV4 MT DTT DMNTCV4 MA Agonist DMNTCV4 RN ClinicalTrials.gov (NCT00701883) Safety and Benefit of MBX-8025 With and Without Commonly Used Statins in Moderately Overweight Patients With High Cholesterol. U. S. National Institute of Health. 2008. DMNTCV4 RU https://clinicaltrials.gov/ct2/show/NCT00701883 DMBIO6E DI DMBIO6E DMBIO6E DN Meclinertant DMBIO6E MI TTTUMEP DMBIO6E MN Neurotensin receptor type 1 (NTSR1) DMBIO6E MT DTT DMBIO6E MA Antagonist DMBIO6E RN Neurotensin inversely modulates maternal aggression. Neuroscience. 2009 Feb 18;158(4):1215-23. DMBIO6E RU https://pubmed.ncbi.nlm.nih.gov/19118604 DMFE0P1 DI DMFE0P1 DMFE0P1 DN Metformin glycinate DMFE0P1 MI TTCBFJO DMFE0P1 MN Insulin receptor (INSR) DMFE0P1 MT DTT DMFE0P1 MA Inhibitor DMFE0P1 RN Effect of Metformin Glycinate on Glycated Hemoglobin A1c Concentration and Insulin Sensitivity in Drug-Naive Adult Patients with Type 2 Diabetes Mellitus. Diabetes Technol Ther. 2012 December; 14(12): 1140-1144. DMFE0P1 RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3521136/ DM752PU DI DM752PU DM752PU DN MGCD516 DM752PU MI TTU8W4S DM752PU MN Protein kinase (PK) DM752PU MT DTT DM752PU MA Inhibitor DM752PU RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DM752PU RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DM752PU DI DM752PU DM752PU DN MGCD516 DM752PU MI TTNDSF4 DM752PU MN Proto-oncogene c-Met (MET) DM752PU MT DTT DM752PU MA Inhibitor DM752PU RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1815). DM752PU RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1815 DM752PU DI DM752PU DM752PU DN MGCD516 DM752PU MI TT4DXQT DM752PU MN Proto-oncogene c-Ret (RET) DM752PU MT DTT DM752PU MA Inhibitor DM752PU RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2185). DM752PU RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2185 DM752PU DI DM752PU DM752PU DN MGCD516 DM752PU MI TTUTJGQ DM752PU MN Vascular endothelial growth factor receptor 2 (KDR) DM752PU MT DTT DM752PU MA Inhibitor DM752PU RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1813). DM752PU RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1813 DM752PU DI DM752PU DM752PU DN MGCD516 DM752PU MI TTDCBX5 DM752PU MN Vascular endothelial growth factor receptor 3 (FLT-4) DM752PU MT DTT DM752PU MA Inhibitor DM752PU RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1814). DM752PU RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1814 DM2YNMI DI DM2YNMI DM2YNMI DN MK-1654 DM2YNMI MI TT57ID8 DM2YNMI MN Respiratory syncytial virus protein F (RSV F) DM2YNMI MT DTT DM2YNMI MA Inhibitor DM2YNMI RN A potent broadly neutralizing human RSV antibody targets conserved site IV of the fusion glycoprotein. Nat Commun. 2019 Sep 12;10(1):4153. DM2YNMI RU https://pubmed.ncbi.nlm.nih.gov/31515478 DMDQOWT DI DMDQOWT DMDQOWT DN MOR-208 DMDQOWT MI TTW640A DMDQOWT MN B-lymphocyte surface antigen B4 (CD19) DMDQOWT MT DTT DMDQOWT RN A phase 1 trial of the Fc-engineered CD19 antibody XmAb5574 (MOR00208) demonstrates safety and preliminary efficacy in relapsed CLL. Blood. 2014 Dec 4;124(24):3553-60. DMDQOWT RU https://pubmed.ncbi.nlm.nih.gov/25301708 DMKMZW2 DI DMKMZW2 DMKMZW2 DN MTC-DOX DMKMZW2 MI TT0IHXV DMKMZW2 MN DNA topoisomerase II (TOP2) DMKMZW2 MT DTT DMKMZW2 MA Modulator DMKMZW2 RN Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41. DMKMZW2 RU https://www.ncbi.nlm.nih.gov/pubmed/15950434 DM16PWF DI DM16PWF DM16PWF DN N1-methylnicotinamide DM16PWF MI DTT79CX DM16PWF MN Organic cation transporter 1 (SLC22A1) DM16PWF MT DTP DM16PWF MA Substrate DM16PWF RN Cloning and characterization of two human polyspecific organic cation transporters. DNA Cell Biol. 1997 Jul;16(7):871-81. DM16PWF RU http://www.ncbi.nlm.nih.gov/pubmed/9260930 DM8D6O2 DI DM8D6O2 DM8D6O2 DN Nafamostat DM8D6O2 MI TTZ3COY DM8D6O2 MN COVID-19 spike glycoprotein (S) DM8D6O2 MT DTT DM8D6O2 MA Inhibitor DM8D6O2 RN Therapeutic options for the 2019 novel coronavirus (2019-nCoV). Nat Rev Drug Discov. 2020 Mar;19(3):149-150. DM8D6O2 RU https://pubmed.ncbi.nlm.nih.gov/32127666 DM8D6O2 DI DM8D6O2 DM8D6O2 DN Nafamostat DM8D6O2 MI TT85VHW DM8D6O2 MN MERS-CoV spike glycoprotein (S) DM8D6O2 MT DTT DM8D6O2 MA Inhibitor DM8D6O2 RN Identification of Nafamostat as a Potent Inhibitor of Middle East Respiratory Syndrome Coronavirus S Protein-Mediated Membrane Fusion Using the Split-Protein-Based Cell-Cell Fusion Assay Antimicrob Agents Chemother. 2016 Oct 21;60(11):6532-6539. DM8D6O2 RU https://pubmed.ncbi.nlm.nih.gov/27550352 DMD5AEB DI DMD5AEB DMD5AEB DN NAL-GLU DMD5AEB MI TT0ID4A DMD5AEB MN Leutinizing-hormone-releasing hormone (GNRH1) DMD5AEB MT DTT DMD5AEB RN The gonadotropin-releasing hormone antagonist (Nal-Glu) acutely blocks the luteinizing hormone surge but allows for resumption of folliculogenesis in normal women. Am J Obstet Gynecol. 1991 Dec;165(6Pt 1):1811-7. DMD5AEB RU https://pubmed.ncbi.nlm.nih.gov/1750480 DM901ZW DI DM901ZW DM901ZW DN Naptumomab estafenatox DM901ZW MI TT70MLA DM901ZW MN Oncotrophoblast glycoprotein 5T4 (TPBG) DM901ZW MT DTT DM901ZW MA Immunomodulator DM901ZW RN Naptumomab estafenatox: targeted immunotherapy with a novel immunotoxin. Curr Oncol Rep. 2014 Feb;16(2):370. DM901ZW RU https://pubmed.ncbi.nlm.nih.gov/24445502 DM3MJUS DI DM3MJUS DM3MJUS DN NBTX-001 DM3MJUS MI TT9IK2Z DM3MJUS MN N-methyl-D-aspartate receptor (NMDAR) DM3MJUS MT DTT DM3MJUS MA Antagonist DM3MJUS RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DM3MJUS RU http://phrma-docs.phrma.org/files/dmfile/MID_Mental-Illness-2017-Drug-List_Final.pdf DM0798Z DI DM0798Z DM0798Z DN NLG8189 DM0798Z MI TTZJYKH DM0798Z MN Indoleamine 2,3-dioxygenase 1 (IDO1) DM0798Z MT DTT DM0798Z MA Inhibitor DM0798Z RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DM0798Z RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DM4H78P DI DM4H78P DM4H78P DN NT-501 DM4H78P MI TTT2F9E DM4H78P MN Ciliary neurotrophic factor receptor alpha (CNTFR) DM4H78P MT DTT DM4H78P MA Modulator DM4H78P RN Clinical pipeline report, company report or official report of Neurotech. DM4H78P RU http://www.neurotechusa.com/cntfrenexus.html DMT13UA DI DMT13UA DMT13UA DN Olokizumab DMT13UA MI TTJH4Y5 DMT13UA MN HUMAN interleukin 6 (IL6) DMT13UA MT DTT DMT13UA MA Inhibitor DMT13UA RN Discovery and characterization of olokizumab: a humanized antibody targeting interleukin-6 and neutralizing gp130-signaling. MAbs. 2014 May-Jun;6(3):774-82. DMT13UA RU https://pubmed.ncbi.nlm.nih.gov/24670876 DMTIESG DI DMTIESG DMTIESG DN Omburtamab DMTIESG MI TT6CQUM DMTIESG MN B7 homolog 3 (CD276) DMTIESG MT DTT DMTIESG MA Inhibitor DMTIESG RN Mast cell proliferation in the cerebrospinal fluid after intraventricular administration of anti-B7H3 immunotherapy. Cancer Immunol Immunother. 2021 Feb 3. DMTIESG RU https://pubmed.ncbi.nlm.nih.gov/33533945 DMPDA17 DI DMPDA17 DMPDA17 DN Omburtamab I-131 DMPDA17 MI TT6CQUM DMPDA17 MN B7 homolog 3 (CD276) DMPDA17 MT DTT DMPDA17 MA Inhibitor DMPDA17 RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMPDA17 RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DMCA2PJ DI DMCA2PJ DMCA2PJ DN ONO-2506 DMCA2PJ MI TTMXGCW DMCA2PJ MN Adrenergic receptor beta-3 (ADRB3) DMCA2PJ MT DTT DMCA2PJ MA Agonist DMCA2PJ RN FR149175, a beta 3-adrenoceptor-selective agonist, is a possible therapeutic agent for non-insulin-dependent diabetes mellitus. Jpn J Pharmacol. 1997 May;74(1):109-12. DMCA2PJ RU https://pubmed.ncbi.nlm.nih.gov/9195306 DMCA2PJ DI DMCA2PJ DMCA2PJ DN ONO-2506 DMCA2PJ MI TTQ0V86 DMCA2PJ MN S100 calcium-binding protein B (S100B) DMCA2PJ MT DTT DMCA2PJ MA Modulator DMCA2PJ RN Arundic acid (ONO-2506) ameliorates delayed ischemic brain damage by preventing astrocytic overproduction of S100B.Curr Drug Targets CNS Neurol Disord.2005 Apr;4(2):127-42. DMCA2PJ RU https://www.ncbi.nlm.nih.gov/pubmed/15857298 DMCTRLN DI DMCTRLN DMCTRLN DN OT-101 DMCTRLN MI TTI0KH6 DMCTRLN MN TGF beta-2 messenger RNA (TGFB2 mRNA) DMCTRLN MT DTT DMCTRLN MA Inhibitor DMCTRLN RN Clinical pipeline report, company report or official report of Oncotelic. DMCTRLN RU https://www.oncotelic.com/pipeline/ DMURH4X DI DMURH4X DMURH4X DN Oxypurinol DMURH4X MI DT2WLAD DMURH4X MN Urate anion exchanger 1 (SLC22A12) DMURH4X MT DTP DMURH4X MA Substrate DMURH4X RN Involvement of uric acid transporter in increased renal clearance of the xanthine oxidase inhibitor oxypurinol induced by a uricosuric agent, benzbromarone. Drug Metab Dispos. 2005 Dec;33(12):1791-5. DMURH4X RU http://www.ncbi.nlm.nih.gov/pubmed/16135657 DMURH4X DI DMURH4X DMURH4X DN Oxypurinol DMURH4X MI TT7RJY8 DMURH4X MN Xanthine dehydrogenase/oxidase (XDH) DMURH4X MT DTT DMURH4X MA Inhibitor DMURH4X RN Oxypurinol as an inhibitor of xanthine oxidase-catalyzed production of superoxide radical. Biochem Pharmacol. 1988 Jan 15;37(2):349-52. DMURH4X RU https://pubmed.ncbi.nlm.nih.gov/2829916 DM0NZDT DI DM0NZDT DM0NZDT DN Pactimibe DM0NZDT MI DECB0K3 DM0NZDT MN Cytochrome P450 2D6 (CYP2D6) DM0NZDT MT DME DM0NZDT MA Metabolism DM0NZDT RN Novel binding mode of the acidic CYP2D6 substrates pactimibe and its metabolite R-125528. Drug Metab Dispos. 2008 Sep;36(9):1938-43. DM0NZDT RU https://www.ncbi.nlm.nih.gov/pubmed/?term=18524873 DM0NZDT DI DM0NZDT DM0NZDT DN Pactimibe DM0NZDT MI TTMF541 DM0NZDT MN Liver carboxylesterase (CES1) DM0NZDT MT DTT DM0NZDT MA Inhibitor DM0NZDT RN Novel indoline-based acyl-CoA:cholesterol acyltransferase inhibitor with antiperoxidative activity: improvement of physicochemical properties and b... J Med Chem. 2008 Aug 14;51(15):4823-33. DM0NZDT RU https://pubmed.ncbi.nlm.nih.gov/18620381 DMRZ1F2 DI DMRZ1F2 DMRZ1F2 DN Padsevonil DMRZ1F2 MI TTCI43M DMRZ1F2 MN GABA(A) receptor (GABAR) DMRZ1F2 MT DTT DMRZ1F2 MA Inhibitor DMRZ1F2 RN Pharmacological Profile of the Novel Antiepileptic Drug Candidate Padsevonil: Characterization in Rodent Seizure and Epilepsy Models. J Pharmacol Exp Ther. 2020 Jan;372(1):11-20. DMRZ1F2 RU https://pubmed.ncbi.nlm.nih.gov/31619464 DMRZ1F2 DI DMRZ1F2 DMRZ1F2 DN Padsevonil DMRZ1F2 MI TTT3P91 DMRZ1F2 MN Synaptic vesicle glycoprotein 2A (SV2A) DMRZ1F2 MT DTT DMRZ1F2 MA Inhibitor DMRZ1F2 RN Pharmacological Profile of the Novel Antiepileptic Drug Candidate Padsevonil: Characterization in Rodent Seizure and Epilepsy Models. J Pharmacol Exp Ther. 2020 Jan;372(1):11-20. DMRZ1F2 RU https://pubmed.ncbi.nlm.nih.gov/31619464 DMHWY2G DI DMHWY2G DMHWY2G DN Pagoclone DMHWY2G MI TTEX6LM DMHWY2G MN GABA(A) receptor gamma-3 (GABRG3) DMHWY2G MT DTT DMHWY2G MA Modulator DMHWY2G RN Evaluation of the abuse potential of pagoclone, a partial GABAA agonist. J Clin Psychopharmacol. 2006 Jun;26(3):268-73. DMHWY2G RU https://pubmed.ncbi.nlm.nih.gov/16702891 DMBJ15R DI DMBJ15R DMBJ15R DN Pexacerfont DMBJ15R MI TT7EFHR DMBJ15R MN Corticotropin-releasing factor receptor 1 (CRHR1) DMBJ15R MT DTT DMBJ15R MA Antagonist DMBJ15R RN Novel drugs and therapeutic targets for severe mood disorders. Neuropsychopharmacology. 2008 Aug;33(9):2080-92. DMBJ15R RU https://pubmed.ncbi.nlm.nih.gov/18172433 DMYKNME DI DMYKNME DMYKNME DN PF-06651600 DMYKNME MI TTT7PJU DMYKNME MN Janus kinase 3 (JAK-3) DMYKNME MT DTT DMYKNME MA Inhibitor DMYKNME RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMYKNME RU http://phrma-docs.phrma.org/files/dmfile/MID_Skin_Diseases_2018_9_FINAL.pdf DM1QSM3 DI DM1QSM3 DM1QSM3 DN Phenol DM1QSM3 MI TTUNARX DM1QSM3 MN Carbonic anhydrase (CA) DM1QSM3 MT DTT DM1QSM3 MA Inhibitor DM1QSM3 RN Carbonic anhydrase inhibitors. Antioxidant polyphenols effectively inhibit mammalian isoforms I-XV. Bioorg Med Chem Lett. 2010 Sep 1;20(17):5050-3. DM1QSM3 RU https://pubmed.ncbi.nlm.nih.gov/20674354 DM1QSM3 DI DM1QSM3 DM1QSM3 DN Phenol DM1QSM3 MI TTHQPL7 DM1QSM3 MN Carbonic anhydrase I (CA-I) DM1QSM3 MT DTT DM1QSM3 MA Inhibitor DM1QSM3 RN Carbonic anhydrase inhibitors. Antioxidant polyphenols effectively inhibit mammalian isoforms I-XV. Bioorg Med Chem Lett. 2010 Sep 1;20(17):5050-3. DM1QSM3 RU https://pubmed.ncbi.nlm.nih.gov/20674354 DM1QSM3 DI DM1QSM3 DM1QSM3 DN Phenol DM1QSM3 MI TTANPDJ DM1QSM3 MN Carbonic anhydrase II (CA-II) DM1QSM3 MT DTT DM1QSM3 MA Inhibitor DM1QSM3 RN Carbonic anhydrase inhibitors. Antioxidant polyphenols effectively inhibit mammalian isoforms I-XV. Bioorg Med Chem Lett. 2010 Sep 1;20(17):5050-3. DM1QSM3 RU https://pubmed.ncbi.nlm.nih.gov/20674354 DM1QSM3 DI DM1QSM3 DM1QSM3 DN Phenol DM1QSM3 MI TTZHA0O DM1QSM3 MN Carbonic anhydrase IV (CA-IV) DM1QSM3 MT DTT DM1QSM3 MA Inhibitor DM1QSM3 RN Carbonic anhydrase inhibitors. Antioxidant polyphenols effectively inhibit mammalian isoforms I-XV. Bioorg Med Chem Lett. 2010 Sep 1;20(17):5050-3. DM1QSM3 RU https://pubmed.ncbi.nlm.nih.gov/20674354 DM1QSM3 DI DM1QSM3 DM1QSM3 DN Phenol DM1QSM3 MI TT2LVK8 DM1QSM3 MN Carbonic anhydrase IX (CA-IX) DM1QSM3 MT DTT DM1QSM3 MA Inhibitor DM1QSM3 RN Carbonic anhydrase inhibitors. Antioxidant polyphenols effectively inhibit mammalian isoforms I-XV. Bioorg Med Chem Lett. 2010 Sep 1;20(17):5050-3. DM1QSM3 RU https://pubmed.ncbi.nlm.nih.gov/20674354 DM1QSM3 DI DM1QSM3 DM1QSM3 DN Phenol DM1QSM3 MI TTSYM0R DM1QSM3 MN Carbonic anhydrase XII (CA-XII) DM1QSM3 MT DTT DM1QSM3 MA Inhibitor DM1QSM3 RN Carbonic anhydrase inhibitors. Antioxidant polyphenols effectively inhibit mammalian isoforms I-XV. Bioorg Med Chem Lett. 2010 Sep 1;20(17):5050-3. DM1QSM3 RU https://pubmed.ncbi.nlm.nih.gov/20674354 DM1QSM3 DI DM1QSM3 DM1QSM3 DN Phenol DM1QSM3 MI TTEYTKG DM1QSM3 MN Carbonic anhydrase XIV (CA-XIV) DM1QSM3 MT DTT DM1QSM3 MA Inhibitor DM1QSM3 RN Carbonic anhydrase inhibitors. Antioxidant polyphenols effectively inhibit mammalian isoforms I-XV. Bioorg Med Chem Lett. 2010 Sep 1;20(17):5050-3. DM1QSM3 RU https://pubmed.ncbi.nlm.nih.gov/20674354 DM1QSM3 DI DM1QSM3 DM1QSM3 DN Phenol DM1QSM3 MI DEVDYN7 DM1QSM3 MN Cytochrome P450 2E1 (CYP2E1) DM1QSM3 MT DME DM1QSM3 MA Metabolism DM1QSM3 RN Summary of information on human CYP enzymes: human P450 metabolism data. Drug Metab Rev. 2002 Feb-May;34(1-2):83-448. DM1QSM3 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=11996015 DM1QSM3 DI DM1QSM3 DM1QSM3 DN Phenol DM1QSM3 MI DED5AT3 DM1QSM3 MN Cytochrome P450 2F1 (CYP2F1) DM1QSM3 MT DME DM1QSM3 MA Metabolism DM1QSM3 RN Cytochrome P450 isozymes involved in the metabolism of phenol, a benzene metabolite. Toxicol Lett. 2001 Dec 15;125(1-3):117-23. DM1QSM3 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=11701230 DM1QSM3 DI DM1QSM3 DM1QSM3 DN Phenol DM1QSM3 MI DEYGVN4 DM1QSM3 MN UDP-glucuronosyltransferase 1A1 (UGT1A1) DM1QSM3 MT DME DM1QSM3 MA Metabolism DM1QSM3 RN Identification of aspartic acid and histidine residues mediating the reaction mechanism and the substrate specificity of the human UDP-glucuronosyltransferases 1A. J Biol Chem. 2007 Dec 14;282(50):36514-24. DM1QSM3 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=17956868 DM1SV8I DI DM1SV8I DM1SV8I DN PHN-131 DM1SV8I MI TTQW87Y DM1SV8I MN Opioid receptor kappa (OPRK1) DM1SV8I MT DTT DM1SV8I MA Agonist DM1SV8I RN Nalbuphine: an autoradiographic opioid receptor binding profile in the central nervous system of an agonist/antagonist analgesic. J Pharmacol Exp Ther. 1988 Jan;244(1):391-402. DM1SV8I RU https://pubmed.ncbi.nlm.nih.gov/2826773 DMPWH30 DI DMPWH30 DMPWH30 DN Pimagedine HCl DMPWH30 MI TTF10I9 DMPWH30 MN Nitric-oxide synthase inducible (NOS2) DMPWH30 MT DTT DMPWH30 MA Inhibitor DMPWH30 RN Nitric oxide associated with iNOS expression inhibits acetylcholinesterase activity and induces memory impairment during acute hypobaric hypoxia. Brain Res. 2008 Sep 16;1230:138-49. DMPWH30 RU https://pubmed.ncbi.nlm.nih.gov/18639532 DM0EFQS DI DM0EFQS DM0EFQS DN Plasminogen DM0EFQS MI TTP86E2 DM0EFQS MN Plasminogen (PLG) DM0EFQS MT DTT DM0EFQS MA Modulator DM0EFQS RN Structure and function of the plasminogen/plasmin system. Thromb Haemost. 2005 Apr;93(4):647-54. DM0EFQS RU https://pubmed.ncbi.nlm.nih.gov/15841308 DMCGK6X DI DMCGK6X DMCGK6X DN PRO 140 DMCGK6X MI TT2CEJG DMCGK6X MN C-C chemokine receptor type 5 (CCR5) DMCGK6X MT DTT DMCGK6X MA Inhibitor DMCGK6X RN The return of PRO 140, a CCR5-directed mAb. Curr Opin HIV AIDS. 2018 Jul;13(4):346-353. DMCGK6X RU https://pubmed.ncbi.nlm.nih.gov/29708899 DMZI4OV DI DMZI4OV DMZI4OV DN QLT-091001 DMZI4OV MI DES5XRU DMZI4OV MN Cytochrome P450 2C8 (CYP2C8) DMZI4OV MT DME DMZI4OV MA Metabolism DMZI4OV RN Effects of arachidonic acid, prostaglandins, retinol, retinoic acid and cholecalciferol on xenobiotic oxidations catalysed by human cytochrome P450 enzymes. Xenobiotica. 1999 Mar;29(3):231-41. DMZI4OV RU https://www.ncbi.nlm.nih.gov/pubmed/?term=10219964 DMB8UQ3 DI DMB8UQ3 DMB8UQ3 DN Ramatroban DMB8UQ3 MI TTQDMX5 DMB8UQ3 MN Prostaglandin D2 receptor 2 (PTGDR2) DMB8UQ3 MT DTT DMB8UQ3 MA Antagonist DMB8UQ3 RN CRTH2-specific binding characteristics of [3H]ramatroban and its effects on PGD2-, 15-deoxy-Delta12, 14-PGJ2- and indomethacin-induced agonist resp... Eur J Pharmacol. 2005 Nov 7;524(1-3):30-7. DMB8UQ3 RU https://pubmed.ncbi.nlm.nih.gov/16256979 DMB8UQ3 DI DMB8UQ3 DMB8UQ3 DN Ramatroban DMB8UQ3 MI TT2O84V DMB8UQ3 MN Thromboxane A2 receptor (TBXA2R) DMB8UQ3 MT DTT DMB8UQ3 MA Antagonist DMB8UQ3 RN Participation in cysteinyl leukotrienes and thromboxane A2 in nasal congestion model in Brown Norway rats. Int Immunopharmacol. 2007 Nov;7(11):1483-7. DMB8UQ3 RU https://pubmed.ncbi.nlm.nih.gov/17761352 DM1LFUN DI DM1LFUN DM1LFUN DN Ravidasvir DM1LFUN MI TTCJ2X8 DM1LFUN MN Hepatitis C virus Non-structural 5A (HCV NS5A) DM1LFUN MT DTT DM1LFUN MA Inhibitor DM1LFUN RN Clinical pipeline report, company report or official report of Presidio Pharmaceuticals. DM1LFUN RU http://www.presidiopharma.com/ DML9FD4 DI DML9FD4 DML9FD4 DN Rinfabate DML9FD4 MI TTHRID2 DML9FD4 MN Insulin-like growth factor I receptor (IGF1R) DML9FD4 MT DTT DML9FD4 MA Modulator DML9FD4 RN Mecasermin rinfabate: insulin-like growth factor-I/insulin-like growth factor binding protein-3, mecaserimin rinfibate, rhIGF-I/rhIGFBP-3. Drugs R D. 2005;6(2):120-7. DML9FD4 RU https://pubmed.ncbi.nlm.nih.gov/15777106 DMWZ6DK DI DMWZ6DK DMWZ6DK DN Roledumab DMWZ6DK MI TTLCKI8 DMWZ6DK MN Blood group Rh(D) polypeptide (RHD) DMWZ6DK MT DTT DMWZ6DK RN Pharmacokinetics and safety of roledumab, a novel human recombinant monoclonal anti-RhD antibody with an optimized Fc for improved engagement of FCgammaRIII, in healthy volunteers. Vox Sang. 2012 Oct;103(3):213-22. DMWZ6DK RU https://pubmed.ncbi.nlm.nih.gov/22568808 DMNIYSZ DI DMNIYSZ DMNIYSZ DN RP101 DMNIYSZ MI TTP3QRF DMNIYSZ MN Thymidine kinase 1 (TK1) DMNIYSZ MT DTT DMNIYSZ MA Inhibitor DMNIYSZ RN DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Nucleic Acids Res. 2011 Jan;39(Database issue):D1035-41. DMNIYSZ RU https://pubmed.ncbi.nlm.nih.gov/21059682 DMOJLCV DI DMOJLCV DMOJLCV DN SAR164877 DMOJLCV MI TTDN3LF DMOJLCV MN Nerve growth factor (NGF) DMOJLCV MT DTT DMOJLCV MA Modulator DMOJLCV RN Fate of novel painkiller mAbs hangs in balance.Nat Biotechnol.2011 Mar;29(3):173-4. DMOJLCV RU https://www.ncbi.nlm.nih.gov/pubmed/21389990 DMH7IPW DI DMH7IPW DMH7IPW DN Sarizotan DMH7IPW MI TTSQIFT DMH7IPW MN 5-HT 1A receptor (HTR1A) DMH7IPW MT DTT DMH7IPW MA Modulator DMH7IPW RN Dual ligands targeting dopamine D2 and serotonin 5-HT1A receptors as new antipsychotical or anti-Parkinsonian agents.Curr Med Chem.2014;21(4):437-57. DMH7IPW RU https://www.ncbi.nlm.nih.gov/pubmed/24164194 DMH7IPW DI DMH7IPW DMH7IPW DN Sarizotan DMH7IPW MI DEJGDUW DMH7IPW MN Cytochrome P450 1A2 (CYP1A2) DMH7IPW MT DME DMH7IPW MA Metabolism DMH7IPW RN In vitro characterization of sarizotan metabolism: hepatic clearance, identification and characterization of metabolites, drug-metabolizing enzyme identification, and evaluation of cytochrome p450 inhibition. Drug Metab Dispos. 2010 Jun;38(6):905-16. DMH7IPW RU https://www.ncbi.nlm.nih.gov/pubmed/?term=20219851 DMH7IPW DI DMH7IPW DMH7IPW DN Sarizotan DMH7IPW MI DES5XRU DMH7IPW MN Cytochrome P450 2C8 (CYP2C8) DMH7IPW MT DME DMH7IPW MA Metabolism DMH7IPW RN In vitro characterization of sarizotan metabolism: hepatic clearance, identification and characterization of metabolites, drug-metabolizing enzyme identification, and evaluation of cytochrome p450 inhibition. Drug Metab Dispos. 2010 Jun;38(6):905-16. DMH7IPW RU https://www.ncbi.nlm.nih.gov/pubmed/?term=20219851 DMH7IPW DI DMH7IPW DMH7IPW DN Sarizotan DMH7IPW MI DE5IED8 DMH7IPW MN Cytochrome P450 2C9 (CYP2C9) DMH7IPW MT DME DMH7IPW MA Metabolism DMH7IPW RN In vitro characterization of sarizotan metabolism: hepatic clearance, identification and characterization of metabolites, drug-metabolizing enzyme identification, and evaluation of cytochrome p450 inhibition. Drug Metab Dispos. 2010 Jun;38(6):905-16. DMH7IPW RU https://www.ncbi.nlm.nih.gov/pubmed/?term=20219851 DMH7IPW DI DMH7IPW DMH7IPW DN Sarizotan DMH7IPW MI DE4LYSA DMH7IPW MN Cytochrome P450 3A4 (CYP3A4) DMH7IPW MT DME DMH7IPW MA Metabolism DMH7IPW RN In vitro characterization of sarizotan metabolism: hepatic clearance, identification and characterization of metabolites, drug-metabolizing enzyme identification, and evaluation of cytochrome p450 inhibition. Drug Metab Dispos. 2010 Jun;38(6):905-16. DMH7IPW RU https://www.ncbi.nlm.nih.gov/pubmed/?term=20219851 DMH7IPW DI DMH7IPW DMH7IPW DN Sarizotan DMH7IPW MI TTEX248 DMH7IPW MN Dopamine D2 receptor (D2R) DMH7IPW MT DTT DMH7IPW MA Modulator DMH7IPW RN Dual ligands targeting dopamine D2 and serotonin 5-HT1A receptors as new antipsychotical or anti-Parkinsonian agents.Curr Med Chem.2014;21(4):437-57. DMH7IPW RU https://www.ncbi.nlm.nih.gov/pubmed/24164194 DM31L9K DI DM31L9K DM31L9K DN Sepofarsen DM31L9K MI TT3XBOV DM31L9K MN CEP290 messenger RNA (CEP290 mRNA) DM31L9K MT DTT DM31L9K MA Inhibitor DM31L9K RN Clinical pipeline report, company report or official report of ProQR Therapeutics. DM31L9K RU https://www.proqr.com/pipeline DMTV5XC DI DMTV5XC DMTV5XC DN Sitafloxacin DMTV5XC MI DTUGYRD DMTV5XC MN P-glycoprotein 1 (ABCB1) DMTV5XC MT DTP DMTV5XC MA Substrate DMTV5XC RN Human intestinal transporter database: QSAR modeling and virtual profiling of drug uptake, efflux and interactions. Pharm Res. 2013 Apr;30(4):996-1007. DMTV5XC RU https://doi.org/10.1007/s11095-012-0935-x DM30JWZ DI DM30JWZ DM30JWZ DN SM04554 DM30JWZ MI TTFPSHI DM30JWZ MN Wnt signaling pathway (Wnt pathway) DM30JWZ MT DTT DM30JWZ MA Modulator DM30JWZ RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DM30JWZ RU http://phrma-docs.phrma.org/files/dmfile/MID_Skin_Diseases_2018_9_FINAL.pdf DMD9ISG DI DMD9ISG DMD9ISG DN SM-88 DMD9ISG MI TT8E7Z0 DMD9ISG MN Free radical (FRD) DMD9ISG MT DTT DMD9ISG MA Stimulator DMD9ISG RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMD9ISG RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DM5WQ2U DI DM5WQ2U DM5WQ2U DN SR-123781A DM5WQ2U MI TT6L509 DM5WQ2U MN Coagulation factor IIa (F2) DM5WQ2U MT DTT DM5WQ2U MA Modulator DM5WQ2U RN SR123781A, a synthetic heparin mimetic. Thromb Haemost. 2001 May;85(5):852-60. DM5WQ2U RU https://pubmed.ncbi.nlm.nih.gov/11372679 DM5WQ2U DI DM5WQ2U DM5WQ2U DN SR-123781A DM5WQ2U MI TTCIHJA DM5WQ2U MN Coagulation factor Xa (F10) DM5WQ2U MT DTT DM5WQ2U MA Modulator DM5WQ2U RN SR123781A, a synthetic heparin mimetic. Thromb Haemost. 2001 May;85(5):852-60. DM5WQ2U RU https://pubmed.ncbi.nlm.nih.gov/11372679 DMKGQF0 DI DMKGQF0 DMKGQF0 DN Suvodirsen DMKGQF0 MI TTWLFXU DMKGQF0 MN Dystrophin messenger RNA (DMD mRNA) DMKGQF0 MT DTT DMKGQF0 MA Inhibitor DMKGQF0 RN Advances in oligonucleotide drug delivery. Nat Rev Drug Discov. 2020 Oct;19(10):673-694. DMKGQF0 RU https://pubmed.ncbi.nlm.nih.gov/32782413 DMWE3GB DI DMWE3GB DMWE3GB DN TG-4010 DMWE3GB MI TTF89GD DMWE3GB MN Interleukin-2 (IL2) DMWE3GB MT DTT DMWE3GB MA Modulator DMWE3GB RN A phase II study of Tg4010 (Mva-Muc1-Il2) in association with chemotherapy in patients with stage III/IV Non-small cell lung cancer. J Thorac Oncol. 2008 Jul;3(7):735-44. DMWE3GB RU https://pubmed.ncbi.nlm.nih.gov/18594319 DMWE3GB DI DMWE3GB DMWE3GB DN TG-4010 DMWE3GB MI TTBHFYQ DMWE3GB MN Mucin-1 (MUC1) DMWE3GB MT DTT DMWE3GB MA Modulator DMWE3GB RN A phase II study of Tg4010 (Mva-Muc1-Il2) in association with chemotherapy in patients with stage III/IV Non-small cell lung cancer. J Thorac Oncol. 2008 Jul;3(7):735-44. DMWE3GB RU https://pubmed.ncbi.nlm.nih.gov/18594319 DMVDTR2 DI DMVDTR2 DMVDTR2 DN Thymoquinone DMVDTR2 MI TTQ57WJ DMVDTR2 MN Apoptosis regulator BAX (BAX) DMVDTR2 MT DTT DMVDTR2 MA Inhibitor DMVDTR2 RN Apoptosis as a mechanism for the treatment of adult T cell leukemia: promising drugs from benchside to bedside. Drug Discov Today. 2020 Jul;25(7):1189-1197. DMVDTR2 RU https://pubmed.ncbi.nlm.nih.gov/32389641 DMVDTR2 DI DMVDTR2 DMVDTR2 DN Thymoquinone DMVDTR2 MI TTJGNVC DMVDTR2 MN Apoptosis regulator Bcl-2 (BCL-2) DMVDTR2 MT DTT DMVDTR2 MA Inhibitor DMVDTR2 RN Apoptosis as a mechanism for the treatment of adult T cell leukemia: promising drugs from benchside to bedside. Drug Discov Today. 2020 Jul;25(7):1189-1197. DMVDTR2 RU https://pubmed.ncbi.nlm.nih.gov/32389641 DMVDTR2 DI DMVDTR2 DMVDTR2 DN Thymoquinone DMVDTR2 MI TT7SBF5 DMVDTR2 MN Cellular tumor antigen p53 (TP53) DMVDTR2 MT DTT DMVDTR2 MA Inhibitor DMVDTR2 RN Apoptosis as a mechanism for the treatment of adult T cell leukemia: promising drugs from benchside to bedside. Drug Discov Today. 2020 Jul;25(7):1189-1197. DMVDTR2 RU https://pubmed.ncbi.nlm.nih.gov/32389641 DM23ARP DI DM23ARP DM23ARP DN V-710 DM23ARP MI TTE0AHP DM23ARP MN Staphylococcus Iron-regulated surface determinant B (Stap-coc isdB) DM23ARP MT DTT DM23ARP RN Effect of an investigational vaccine for preventing Staphylococcus aureus infections after cardiothoracic surgery: a randomized trial. JAMA. 2013 Apr 3;309(13):1368-78. DM23ARP RU https://pubmed.ncbi.nlm.nih.gov/23549582 DMDG8Q3 DI DMDG8Q3 DMDG8Q3 DN Varlitinib DMDG8Q3 MI TTGKNB4 DMDG8Q3 MN Epidermal growth factor receptor (EGFR) DMDG8Q3 MT DTT DMDG8Q3 MA Modulator DMDG8Q3 RN Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41. DMDG8Q3 RU https://www.ncbi.nlm.nih.gov/pubmed/15950434 DMDG8Q3 DI DMDG8Q3 DMDG8Q3 DN Varlitinib DMDG8Q3 MI TT6EO5L DMDG8Q3 MN Erbb2 tyrosine kinase receptor (HER2) DMDG8Q3 MT DTT DMDG8Q3 MA Modulator DMDG8Q3 RN Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41. DMDG8Q3 RU https://www.ncbi.nlm.nih.gov/pubmed/15950434 DMTROUI DI DMTROUI DMTROUI DN Vazegepant DMTROUI MI TT67OLB DMTROUI MN HUMAN calcitonin gene-related peptide type 1 receptor (CALCRL) DMTROUI MT DTT DMTROUI MA Inhibitor DMTROUI RN Safety and Efficacy Trial of Zavegepant* Intranasal for Hospitalized Patients With COVID-19 Requiring Supplemental Oxygen DMTROUI RU https://clinicaltrials.gov/ct2/show/NCT04346615 DMGKRAJ DI DMGKRAJ DMGKRAJ DN VB4-845 DMGKRAJ MI TTZ8WH4 DMGKRAJ MN Tumor-associated calcium signal transducer 1 (EPCAM) DMGKRAJ MT DTT DMGKRAJ RN A bispecific EpCAM/CD133 targeted toxin is effective against carcinoma. Target Oncol. 2014 September; 9(3): 239-249. DMGKRAJ RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3994189/ DM0ASTP DI DM0ASTP DM0ASTP DN Verapamil DM0ASTP MI TTHQJ2Y DM0ASTP MN HUMAN two pore channel subtype 2 (TPC2) DM0ASTP MT DTT DM0ASTP MA Blocker DM0ASTP RN Characterization of spike glycoprotein of SARS-CoV-2 on virus entry and its immune cross-reactivity with SARS-CoV. Nat Commun. 2020 Mar 27;11(1):1620. DM0ASTP RU https://pubmed.ncbi.nlm.nih.gov/32221306 DM4WQBO DI DM4WQBO DM4WQBO DN VM-1500 DM4WQBO MI TT84ETX DM4WQBO MN Human immunodeficiency virus Reverse transcriptase (HIV RT) DM4WQBO MT DTT DM4WQBO MA Inhibitor DM4WQBO RN 127 afety, pharmokinetics and efficacy of VM-1500, a novel reverse transcriptase inhibitor, In healthy volunteers and HIV-infected patients. J Acquir Immune Defic Syndr. 2014 April; 65(Suppl 2): 52. DM4WQBO RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4149639/ DM5G1NT DI DM5G1NT DM5G1NT DN VX-210 DM5G1NT MI TTXEVN8 DM5G1NT MN Transforming protein Rho (RHO) DM5G1NT MT DTT DM5G1NT MA Inhibitor DM5G1NT RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DM5G1NT RU http://phrma-docs.phrma.org/files/dmfile/MID_Neurological-Disorders-Drug-List_2018.pdf DM2U3MX DI DM2U3MX DM2U3MX DN VX-509 DM2U3MX MI TTT7PJU DM2U3MX MN Janus kinase 3 (JAK-3) DM2U3MX MT DTT DM2U3MX MA Inhibitor DM2U3MX RN Selective JAK inhibitors in development for rheumatoid arthritis. Expert Opin Investig Drugs. 2014 Aug;23(8):1067-77. DM2U3MX RU https://pubmed.ncbi.nlm.nih.gov/24818516 DMHXJ68 DI DMHXJ68 DMHXJ68 DN WVE-210201 DMHXJ68 MI TT48MP6 DMHXJ68 MN Dystrophin (DMD) DMHXJ68 MT DTT DMHXJ68 MA Modulator DMHXJ68 RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMHXJ68 RU http://phrma-docs.phrma.org/files/dmfile/MID_Neurological-Disorders-Drug-List_2018.pdf DM78DOT DI DM78DOT DM78DOT DN AllerB DM78DOT MI TT9V5JH DM78DOT MN Phospholipase A2 (PLA2G1B) DM78DOT MT DTT DM78DOT MA Inhibitor DM78DOT RN Successful immunotherapy with T-cell epitope peptides of bee venom phospholipase A2 induces specific T-cell anergy in patients allergic to bee venom. J Allergy Clin Immunol. 1998 Jun;101(6 Pt 1):747-54. DM78DOT RU https://pubmed.ncbi.nlm.nih.gov/9648701 DMJM9LZ DI DMJM9LZ DMJM9LZ DN LB80380 DMJM9LZ MI TTS5K1M DMJM9LZ MN Hepatitis B virus Reverse transcriptase (HBV RT) DMJM9LZ MT DTT DMJM9LZ MA Inhibitor DMJM9LZ RN 2011 Pipeline of LG Life Sciences. DMJM9LZ RU http://www.lgls.com/ DMXB4NL DI DMXB4NL DMXB4NL DN MEDI4893 DMXB4NL MI TT5FLYB DMXB4NL MN Staphylococcus Alpha-hemolysin (Stap-coc hly) DMXB4NL MT DTT DMXB4NL RN Mechanisms of neutralization of a human anti-alpha-toxin antibody. J Biol Chem. 2014 Oct 24;289(43):29874-80. DMXB4NL RU https://pubmed.ncbi.nlm.nih.gov/25210036 DMEARCM DI DMEARCM DMEARCM DN OrM3 DMEARCM MI TTH18TF DMEARCM MN Muscarinic acetylcholine receptor M5 (CHRM5) DMEARCM MT DTT DMEARCM MA Antagonist DMEARCM RN Emerging drugs in chronic obstructive pulmonary disease. Expert Opin Emerg Drugs. 2009 Mar;14(1):181-94. DMEARCM RU https://pubmed.ncbi.nlm.nih.gov/19265487 DMOE582 DI DMOE582 DMOE582 DN TZP-101 DMOE582 MI TTWDC17 DMOE582 MN Growth hormone secretagogue receptor 1 (GHSR) DMOE582 MT DTT DMOE582 MA Agonist DMOE582 RN Contribution of protein binding to the pharmacokinetics of the ghrelin receptor agonist TZP-101 in healthy volunteers and adults with symptomatic gastroparesis: two randomized, double-blind studies and a binding profile study. Clin Drug Investig. 2009;29(6):409-18. DMOE582 RU https://pubmed.ncbi.nlm.nih.gov/19432500 DMUB8WN DI DMUB8WN DMUB8WN DN Aerovant DMUB8WN MI TTDWHC3 DMUB8WN MN Interleukin 4 receptor alpha (IL4R) DMUB8WN MT DTT DMUB8WN MA Antagonist DMUB8WN RN Aerovance starts trial of Aerovant for uncontrolled asthma. Aerovance. March 3, 2009. DMUB8WN RU http://www.news-medical.net/news/2009/03/03/46411.aspx DMSC8YW DI DMSC8YW DMSC8YW DN ANA773 DMSC8YW MI TTRJ1K4 DMSC8YW MN Toll-like receptor 7 (TLR7) DMSC8YW MT DTT DMSC8YW MA Agonist DMSC8YW RN Clinical pipeline report, company report or official report of Anadys Pharmaceuticals (2011). DMSC8YW RU http://www.anadyspharma.com/ DMJBDL0 DI DMJBDL0 DMJBDL0 DN BIIB104 DMJBDL0 MI TTAN6JD DMJBDL0 MN Glutamate receptor AMPA (GRIA) DMJBDL0 MT DTT DMJBDL0 MA Activator DMJBDL0 RN Antibodies and venom peptides: new modalities for ion channels. Nat Rev Drug Discov. 2019 May;18(5):339-357. DMJBDL0 RU https://pubmed.ncbi.nlm.nih.gov/30728472 DM0TH9A DI DM0TH9A DM0TH9A DN Bimosiamose DM0TH9A MI TTAU4D6 DM0TH9A MN E-selectin (SELE) DM0TH9A MT DTT DM0TH9A MA Inhibitor DM0TH9A RN Effects of the pan-selectin antagonist bimosiamose (TBC1269) in experimental human endotoxemia. Shock. 2008 Apr;29(4):475-82. DM0TH9A RU https://pubmed.ncbi.nlm.nih.gov/18598003 DMR6LXM DI DMR6LXM DMR6LXM DN CAP-232 DMR6LXM MI TT4LOT8 DMR6LXM MN Pyruvate kinase M2 (PKM) DMR6LXM MT DTT DMR6LXM MA Modulator DMR6LXM RN Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41. DMR6LXM RU https://www.ncbi.nlm.nih.gov/pubmed/15950434 DMLQ3PO DI DMLQ3PO DMLQ3PO DN INCB13739 DMLQ3PO MI TTN7BL9 DMLQ3PO MN Corticosteroid 11-beta-dehydrogenase 1 (HSD11B1) DMLQ3PO MT DTT DMLQ3PO MA Inhibitor DMLQ3PO RN Incyte's Selective Oral Inhibitor Of 11beta-HSD1 Demonstrates Improvements In Insulin Sensitivity And Lowers Cholesterol Levels In Type 2 Diabetics. Incyte. 2008. DMLQ3PO RU http://www.medicalnewstoday.com/articles/110647.php DMLQ3PO DI DMLQ3PO DMLQ3PO DN INCB13739 DMLQ3PO MI TTWC6MY DMLQ3PO MN Protein tyrosine phosphatase (PTP) DMLQ3PO MT DTT DMLQ3PO MA Inhibitor DMLQ3PO RN Induction of endothelial cell surface adhesion molecules by tumor necrosis factor is blocked by protein tyrosine phosphatase inhibitors: role of the nuclear transcription factor NF-kappa B. Eur J Immunol. 1997 Sep;27(9):2172-9. DMLQ3PO RU https://pubmed.ncbi.nlm.nih.gov/9341756 DMMWC6F DI DMMWC6F DMMWC6F DN INCB9471 DMMWC6F MI TT2CEJG DMMWC6F MN C-C chemokine receptor type 5 (CCR5) DMMWC6F MT DTT DMMWC6F MA Antagonist DMMWC6F RN Species selectivity of small-molecular antagonists for the CCR5 chemokine receptor. Int Immunopharmacol. 2007 Dec 5;7(12):1528-34. DMMWC6F RU https://pubmed.ncbi.nlm.nih.gov/17920529 DMYZU6G DI DMYZU6G DMYZU6G DN MEM-1003 DMYZU6G MI TTXHYV6 DMYZU6G MN Voltage-gated L-type calcium channel (L-CaC) DMYZU6G MT DTT DMYZU6G MA Modulator DMYZU6G RN Efficacy of MEM 1003, a novel calcium channel blocker, in delay and trace eyeblink conditioning in older rabbits. Neurobiol Aging. 2007 May;28(5):766-73. DMYZU6G RU https://pubmed.ncbi.nlm.nih.gov/16621170 DMGM1IR DI DMGM1IR DMGM1IR DN RhuDex DMGM1IR MI TTFZDNP DMGM1IR MN Activation B7-1 antigen (CD80) DMGM1IR MT DTT DMGM1IR MA Inhibitor DMGM1IR RN A phase 1 study of AS1409, a novel antibody-cytokine fusion protein, in patients with malignant melanoma or renal cell carcinoma. Clin Cancer Res. 2011 Apr 1;17(7):1998-2005. DMGM1IR RU https://pubmed.ncbi.nlm.nih.gov/21447719 DMKJDR6 DI DMKJDR6 DMKJDR6 DN VX-702 DMKJDR6 MI TTQBR95 DMKJDR6 MN Stress-activated protein kinase 2a (p38 alpha) DMKJDR6 MT DTT DMKJDR6 MA Modulator DMKJDR6 RN Efficacy, pharmacodynamics, and safety of VX-702, a novel p38 MAPK inhibitor, in rheumatoid arthritis: results of two randomized, double-blind, placebo-controlled clinical studies. Arthritis Rheum. 2009 May;60(5):1232-41. DMKJDR6 RU https://pubmed.ncbi.nlm.nih.gov/19404957 DMAV426 DI DMAV426 DMAV426 DN (S)-oxybutynin DMAV426 MI TTZ9SOR DMAV426 MN Muscarinic acetylcholine receptor M1 (CHRM1) DMAV426 MT DTT DMAV426 MA Antagonist DMAV426 RN Enantiomers of oxybutynin: in vitro pharmacological characterization at M1, M2 and M3 muscarinic receptors and in vivo effects on urinary bladder contraction, mydriasis and salivary secretion in guinea pigs. J Pharmacol Exp Ther. 1991 Feb;256(2):562-7. DMAV426 RU https://pubmed.ncbi.nlm.nih.gov/1993995 DMGDOS2 DI DMGDOS2 DMGDOS2 DN (Z)-endoxifen DMGDOS2 MI DTUGYRD DMGDOS2 MN P-glycoprotein 1 (ABCB1) DMGDOS2 MT DTP DMGDOS2 MA Substrate DMGDOS2 RN P-glycoprotein (ABCB1) transports the primary active tamoxifen metabolites endoxifen and 4-hydroxytamoxifen and restricts their brain penetration. J Pharmacol Exp Ther. 2011 Jun;337(3):710-7. DMGDOS2 RU https://doi.org/10.1124/jpet.110.178301 DMV86DY DI DMV86DY DMV86DY DN [131I]-BC8 DMV86DY MI TTUS45N DMV86DY MN Leukocyte common antigen (PTPRC) DMV86DY MT DTT DMV86DY RN Development of a marrow transplant regimen for acute leukemia using targeted hematopoietic irradiation delivered by 131I-labeled anti-CD45 antibody, combined with cyclophosphamide and total body irradiation. Blood. 1995 Feb 15;85(4):1122-31. DMV86DY RU https://pubmed.ncbi.nlm.nih.gov/7849300 DM4VWXI DI DM4VWXI DM4VWXI DN [131I]-Metuximab DM4VWXI MI TT5UJWD DM4VWXI MN Basigin (BSG) DM4VWXI MT DTT DM4VWXI RN Targeting radioimmunotherapy of hepatocellular carcinoma with iodine (131I) metuximab injection: clinical phase I/II trials. Int J Radiat Oncol Biol Phys. 2006 Jun 1;65(2):435-44. DM4VWXI RU https://pubmed.ncbi.nlm.nih.gov/16690431 DMSLMY7 DI DMSLMY7 DMSLMY7 DN 11C-PBR-28 DMSLMY7 MI TTPTXIN DMSLMY7 MN Translocator protein (TSPO) DMSLMY7 MT DTT DMSLMY7 MA Binder DMSLMY7 RN PET imaging with [11C]PBR28 can localize and quantify upregulated peripheral benzodiazepine receptors associated with cerebral ischemia in rat. Neurosci Lett. 2007 Jan 16;411(3):200-5. DMSLMY7 RU https://pubmed.ncbi.nlm.nih.gov/17127001 DMTIED1 DI DMTIED1 DMTIED1 DN 131I-TM-601 DMTIED1 MI TTCYAXN DMTIED1 MN Chloride channel unspecific (ClC) DMTIED1 MT DTT DMTIED1 MA Inhibitor DMTIED1 RN Imaging glioma extent with 131I-TM-601. J Nucl Med. 2005 Apr;46(4):580-6. DMTIED1 RU https://pubmed.ncbi.nlm.nih.gov/15809479 DM4EP6Y DI DM4EP6Y DM4EP6Y DN 13-DEOXYADRIAMYCIN HYDROCHLORIDE DM4EP6Y MI TT0IHXV DM4EP6Y MN DNA topoisomerase II (TOP2) DM4EP6Y MT DTT DM4EP6Y MA Modulator DM4EP6Y RN Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41. DM4EP6Y RU https://www.ncbi.nlm.nih.gov/pubmed/15950434 DM4EP6Y DI DM4EP6Y DM4EP6Y DN 13-DEOXYADRIAMYCIN HYDROCHLORIDE DM4EP6Y MI TTUTN1I DM4EP6Y MN Human Deoxyribonucleic acid (hDNA) DM4EP6Y MT DTT DM4EP6Y MA Modulator DM4EP6Y RN Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41. DM4EP6Y RU https://www.ncbi.nlm.nih.gov/pubmed/15950434 DMNF38S DI DMNF38S DMNF38S DN 16,16-dimethyl-PGE2 DMNF38S MI TT1ZAVI DMNF38S MN Prostaglandin E2 receptor EP2 (PTGER2) DMNF38S MT DTT DMNF38S MA Agonist DMNF38S RN Ligand binding specificities of the eight types and subtypes of the mouse prostanoid receptors expressed in Chinese hamster ovary cells. Br J Pharmacol. 1997 Sep;122(2):217-24. DMNF38S RU https://pubmed.ncbi.nlm.nih.gov/9313928 DMNF38S DI DMNF38S DMNF38S DN 16,16-dimethyl-PGE2 DMNF38S MI TTPNGDE DMNF38S MN Prostaglandin E2 receptor EP3 (PTGER3) DMNF38S MT DTT DMNF38S MA Agonist DMNF38S RN Ligand binding specificities of the eight types and subtypes of the mouse prostanoid receptors expressed in Chinese hamster ovary cells. Br J Pharmacol. 1997 Sep;122(2):217-24. DMNF38S RU https://pubmed.ncbi.nlm.nih.gov/9313928 DMNF38S DI DMNF38S DMNF38S DN 16,16-dimethyl-PGE2 DMNF38S MI TT79WV3 DMNF38S MN Prostaglandin E2 receptor EP4 (PTGER4) DMNF38S MT DTT DMNF38S MA Agonist DMNF38S RN Ligand binding specificities of the eight types and subtypes of the mouse prostanoid receptors expressed in Chinese hamster ovary cells. Br J Pharmacol. 1997 Sep;122(2):217-24. DMNF38S RU https://pubmed.ncbi.nlm.nih.gov/9313928 DMT8GVU DI DMT8GVU DMT8GVU DN 177Lu-DOTATATE DMT8GVU MI TTOMNR9 DMT8GVU MN Somatostatin receptor (SSTR) DMT8GVU MT DTT DMT8GVU MA Modulator DMT8GVU RN Peptide receptor radionuclide therapy with 177Lu-DOTATATE for patients with somatostatin receptor-expressing neuroendocrine tumors: the first US phase 2 experience. Pancreas. 2014 May;43(4):518-25. DMT8GVU RU https://pubmed.ncbi.nlm.nih.gov/24632546 DMT8GVU DI DMT8GVU DMT8GVU DN 177Lu-DOTATATE DMT8GVU MI TTAE1BR DMT8GVU MN Somatostatin receptor type 4 (SSTR4) DMT8GVU MT DTT DMT8GVU MA Inhibitor DMT8GVU RN New Drug in Development Shows Improved Progression-Free Survival for Patients with Advanced Metastatic Midgut Neuroendocrine Tumors DMT8GVU RU https://www.cancercommons.org/tag/177lu-dotatate/ DM2TSMD DI DM2TSMD DM2TSMD DN 177Lu-labelled NeoBOMB1 DM2TSMD MI TTC1MVT DM2TSMD MN Gastrin-releasing peptide receptor (GRPR) DM2TSMD MT DTT DM2TSMD RN 68Ga/177Lu-NeoBOMB1, a Novel Radiolabeled GRPR Antagonist for Theranostic Use in Oncology. J Nucl Med. 2017 Feb;58(2):293-299. DM2TSMD RU https://pubmed.ncbi.nlm.nih.gov/27609789 DM8JVIB DI DM8JVIB DM8JVIB DN 18F-LMI-1195 DM8JVIB MI TTAWNKZ DM8JVIB MN Norepinephrine transporter (NET) DM8JVIB MT DTT DM8JVIB MA Enhancer DM8JVIB RN Assessment of the 18F-labeled PET tracer LMI1195 for imaging norepinephrine handling in rat hearts. J Nucl Med. 2013 Jul;54(7):1142-6. DM8JVIB RU https://pubmed.ncbi.nlm.nih.gov/23670901 DMZWNQF DI DMZWNQF DMZWNQF DN 2'3'-Dideoxyinosine DMZWNQF MI TTMCF1Y DMZWNQF MN Purine nucleoside phosphorylase (PNP) DMZWNQF MT DTT DMZWNQF MA Inhibitor DMZWNQF RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMZWNQF RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMBOL4K DI DMBOL4K DMBOL4K DN 264W94 DMBOL4K MI TTPI1M5 DMBOL4K MN Ileal sodium/bile acid cotransporter (SLC10A2) DMBOL4K MT DTT DMBOL4K MA Modulator DMBOL4K RN Inhibition of apical sodium-dependent bile acid transporter as a novel treatment for diabetes. Am J Physiol Endocrinol Metab. 2012 Jan 1;302(1):E68-76. DMBOL4K RU https://pubmed.ncbi.nlm.nih.gov/21934041 DMGBPME DI DMGBPME DMGBPME DN 2-Methoxyestradiol DMGBPME MI DE6OQ3W DMGBPME MN Cytochrome P450 1A1 (CYP1A1) DMGBPME MT DME DMGBPME MA Metabolism DMGBPME RN Role of 2-methoxyestradiol, an Endogenous Estrogen Metabolite, in Health and Disease. Mini Rev Med Chem. 2015;15(5):427-38. DMGBPME RU https://www.ncbi.nlm.nih.gov/pubmed/?term=25723461 DMGBPME DI DMGBPME DMGBPME DN 2-Methoxyestradiol DMGBPME MI TTQHWNA DMGBPME MN Hypoxia-inducible factor 1 alpha (HIF-1A) DMGBPME MT DTT DMGBPME MA Modulator DMGBPME RN 2-methoxyestradiol inhibits hypoxia-inducible factor 1alpha, tumor growth, and angiogenesis and augments paclitaxel efficacy in head and neck squam... Clin Cancer Res. 2004 Dec 15;10(24):8665-73. DMGBPME RU https://www.ncbi.nlm.nih.gov/pubmed/15623651 DMX9MSL DI DMX9MSL DMX9MSL DN 2X-121 DMX9MSL MI TTEBCY8 DMX9MSL MN Poly [ADP-ribose] polymerase (PARP) DMX9MSL MT DTT DMX9MSL MA Inhibitor DMX9MSL RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMX9MSL RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DMX9MSL DI DMX9MSL DMX9MSL DN 2X-121 DMX9MSL MI TTKSAQZ DMX9MSL MN Tankyrase (TNKS) DMX9MSL MT DTT DMX9MSL MA Inhibitor DMX9MSL RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMX9MSL RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DML8M5T DI DML8M5T DML8M5T DN 3,5-diiodothyropropionic acid DML8M5T MI DE4LYSA DML8M5T MN Cytochrome P450 3A4 (CYP3A4) DML8M5T MT DME DML8M5T MA Metabolism DML8M5T RN Guidelines for the treatment of hypothyroidism: prepared by the american thyroid association task force on thyroid hormone replacement. Thyroid. 2014 Dec;24(12):1670-751. DML8M5T RU https://www.ncbi.nlm.nih.gov/pubmed/?term=25266247 DMTLR6Y DI DMTLR6Y DMTLR6Y DN 3K3A-APC DMTLR6Y MI TTZUXYS DMTLR6Y MN Vitamin K-dependent protein C (PROC) DMTLR6Y MT DTT DMTLR6Y MA Modulator DMTLR6Y RN Preclinical safety and pharmacokinetic profile of 3K3A-APC, a novel, modified activated protein C for ischemic stroke. Curr Pharm Des. 2012;18(27):4215-22. DMTLR6Y RU https://pubmed.ncbi.nlm.nih.gov/22632606 DMPFVJB DI DMPFVJB DMPFVJB DN 5-hydroxymethyl-2-furfural DMPFVJB MI TTQO71U DMPFVJB MN Hemoglobin (HB) DMPFVJB MT DTT DMPFVJB MA Modulator DMPFVJB RN 5-hydroxymethyl-2-furfural modifies intracellular sickle haemoglobin and inhibits sickling of red blood cells. Br J Haematol. 2005 Feb;128(4):552-61. DMPFVJB RU https://pubmed.ncbi.nlm.nih.gov/15686467 DMHBN8X DI DMHBN8X DMHBN8X DN 60P002 DMHBN8X MI TTQL5VC DMHBN8X MN Platelet-activating factor receptor (PTAFR) DMHBN8X MT DTT DMHBN8X MA Antagonist DMHBN8X RN Clinical pipeline report, company report or official report of 60 Degrees Pharmaceuticals. DMHBN8X RU https://60degreespharma.com/research-development/clinical-pipeline/ DMOV0AP DI DMOV0AP DMOV0AP DN 842166X DMOV0AP MI TTMSFAW DMOV0AP MN Cannabinoid receptor 2 (CB2) DMOV0AP MT DTT DMOV0AP MA Agonist DMOV0AP RN The agonist binding mechanism of human CB2 receptor studied by molecular dynamics simulation, free energy calculation and 3D-QSAR studies. Yao Xue Xue Bao. 2013 Sep;48(9):1436-49. DMOV0AP RU https://pubmed.ncbi.nlm.nih.gov/24358778 DML4GU1 DI DML4GU1 DML4GU1 DN 99mTc-MIP-1404 DML4GU1 MI TT9G4N0 DML4GU1 MN Glutamate carboxypeptidase II (GCPII) DML4GU1 MT DTT DML4GU1 MA Modulator DML4GU1 RN 99mTc-labeled small-molecule inhibitors of prostate-specific membrane antigen for molecular imaging of prostate cancer. J Nucl Med. 2013 Aug;54(8):1369-76. DML4GU1 RU https://pubmed.ncbi.nlm.nih.gov/23733925 DMX2LO3 DI DMX2LO3 DMX2LO3 DN 99mTc-RP-128 DMX2LO3 MI TTYG378 DMX2LO3 MN Tuftsin receptor (TR) DMX2LO3 MT DTT DMX2LO3 MA Modulator DMX2LO3 RN WO patent application no. 2013,1850,32, Nanotherapeutics for drug targeting. DMX2LO3 RU http://worldwide.espacenet.com/publicationDetails/biblio?DB=worldwide.espacenet.com&II=0&ND=3&adjacent=true&locale=en_EP&FT=D&date=20131212&CC=WO&NR=2013185032A1&KC=A1 DMQXYRG DI DMQXYRG DMQXYRG DN 9-AMINOCAMPTOTHECIN DMQXYRG MI DTI7UX6 DMQXYRG MN Breast cancer resistance protein (ABCG2) DMQXYRG MT DTP DMQXYRG MA Substrate DMQXYRG RN Pharmacogenomic importance of ABCG2. Pharmacogenomics. 2008 Aug;9(8):1005-9. DMQXYRG RU https://doi.org/10.2217/14622416.9.8.1005 DMQXYRG DI DMQXYRG DMQXYRG DN 9-AMINOCAMPTOTHECIN DMQXYRG MI DE6OQ3W DMQXYRG MN Cytochrome P450 1A1 (CYP1A1) DMQXYRG MT DME DMQXYRG MA Metabolism DMQXYRG RN Cytochrome P450 3A-mediated metabolism of the topoisomerase I inhibitor 9-aminocamptothecin: impact on cancer therapy. Int J Oncol. 2014 Aug;45(2):877-86. DMQXYRG RU https://www.ncbi.nlm.nih.gov/pubmed/?term=24889073 DMQXYRG DI DMQXYRG DMQXYRG DN 9-AMINOCAMPTOTHECIN DMQXYRG MI DE4LYSA DMQXYRG MN Cytochrome P450 3A4 (CYP3A4) DMQXYRG MT DME DMQXYRG MA Metabolism DMQXYRG RN Cytochrome P450 3A-mediated metabolism of the topoisomerase I inhibitor 9-aminocamptothecin: impact on cancer therapy. Int J Oncol. 2014 Aug;45(2):877-86. DMQXYRG RU https://www.ncbi.nlm.nih.gov/pubmed/?term=24889073 DMQXYRG DI DMQXYRG DMQXYRG DN 9-AMINOCAMPTOTHECIN DMQXYRG MI TTGTQHC DMQXYRG MN DNA topoisomerase I (TOP1) DMQXYRG MT DTT DMQXYRG MA Inhibitor DMQXYRG RN Intraperitoneal topoisomerase-I inhibitors. Preliminary findings with 9-aminocamptothecin. Ann N Y Acad Sci. 2000;922:178-87. DMQXYRG RU https://pubmed.ncbi.nlm.nih.gov/11193893 DM57TY3 DI DM57TY3 DM57TY3 DN 9-ING-41 DM57TY3 MI TTRSMW9 DM57TY3 MN Glycogen synthase kinase-3 beta (GSK-3B) DM57TY3 MT DTT DM57TY3 MA Inhibitor DM57TY3 RN 9-ING-41, a small molecule inhibitor of GSK-3beta, potentiates the effects of anticancer therapeutics in bladder cancer. Sci Rep. 2019 Dec 27;9(1):19977. DM57TY3 RU https://pubmed.ncbi.nlm.nih.gov/31882719 DM6ZIES DI DM6ZIES DM6ZIES DN A-6 DM6ZIES MI TTWFBT7 DM6ZIES MN Extracellular matrix receptor III (CD44) DM6ZIES MT DTT DM6ZIES MA Modulator DM6ZIES RN Modulation of CD44 Activity by A6-Peptide.Front Immunol.2015 Mar 30;6:135. DM6ZIES RU https://www.ncbi.nlm.nih.gov/pubmed/25870596 DMHOLB7 DI DMHOLB7 DMHOLB7 DN A-85380 DMHOLB7 MI TTJSZTB DMHOLB7 MN Nicotinic acetylcholine receptor (nAChR) DMHOLB7 MT DTT DMHOLB7 MA Agonist DMHOLB7 RN The therapeutic potential of nicotinic acetylcholine receptor agonists for pain control. Expert Opin Investig Drugs. 2001 Oct;10(10):1819-30. DMHOLB7 RU https://pubmed.ncbi.nlm.nih.gov/11772288 DMOGDCQ DI DMOGDCQ DMOGDCQ DN Ab-01 DMOGDCQ MI TTZO9B0 DMOGDCQ MN Interleukin 21 receptor (IL21R) DMOGDCQ MT DTT DMOGDCQ RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2304). DMOGDCQ RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2304 DMEW62S DI DMEW62S DMEW62S DN AB-106 DMEW62S MI TTSZ6Y3 DMEW62S MN Proto-oncogene c-Ros (ROS1) DMEW62S MT DTT DMEW62S MA Inhibitor DMEW62S RN Clinical pipeline report, company report or official report of AnHeart Therapeutics. DMEW62S RU https://anhearttherapeutics.com/pipeline/ DMEW62S DI DMEW62S DMEW62S DN AB-106 DMEW62S MI TTJOCTY DMEW62S MN Tropomyosin receptor kinase (Trk) DMEW62S MT DTT DMEW62S MA Inhibitor DMEW62S RN Clinical pipeline report, company report or official report of AnHeart Therapeutics. DMEW62S RU https://anhearttherapeutics.com/pipeline/ DM48DPS DI DM48DPS DM48DPS DN AB-729 DM48DPS MI TT43YWN DM48DPS MN Hepatitis B virus messenger RNA (HBV mRNA) DM48DPS MT DTT DM48DPS MA Inhibitor DM48DPS RN Clinical pipeline report, company report or official report of Arbutus Biopharma. DM48DPS RU http://www.arbutusbio.com/portfolio/ab-729-galnac-rnai.php DM4ZLTY DI DM4ZLTY DM4ZLTY DN ABBV-2222 DM4ZLTY MI TTRLZHP DM4ZLTY MN cAMP-dependent chloride channel (CFTR) DM4ZLTY MT DTT DM4ZLTY MA Modulator DM4ZLTY RN Antibodies and venom peptides: new modalities for ion channels. Nat Rev Drug Discov. 2019 May;18(5):339-357. DM4ZLTY RU https://pubmed.ncbi.nlm.nih.gov/30728472 DMT6H3J DI DMT6H3J DMT6H3J DN AbGn-168 DMT6H3J MI TTS5K8U DMT6H3J MN P-selectin glycoprotein ligand 1 (SELPLG) DMT6H3J MT DTT DMT6H3J RN Clinical pipeline report, company report or official report of Avarx. DMT6H3J RU http://www.avarx.com/AvaRx/SubDomains/bucket3739906636580370793/Listings/bucket460336945731305549/Public.Listing.display.html DMQ6KZM DI DMQ6KZM DMQ6KZM DN ABI-009 DMQ6KZM MI TTCJG29 DMQ6KZM MN Serine/threonine-protein kinase mTOR (mTOR) DMQ6KZM MT DTT DMQ6KZM MA Inhibitor DMQ6KZM RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMQ6KZM RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DM59OJ2 DI DM59OJ2 DM59OJ2 DN Abicipar pegol DM59OJ2 MI TTOHSBA DM59OJ2 MN Vascular endothelial growth factor A (VEGFA) DM59OJ2 MT DTT DM59OJ2 MA Inhibitor DM59OJ2 RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DM59OJ2 RU http://phrma-docs.phrma.org/files/dmfile/mid-diabetes-drug-list.pdf DMX1KDM DI DMX1KDM DMX1KDM DN ABI-H0731 DMX1KDM MI TTM42UJ DMX1KDM MN Hepatitis B virus Capsid protein (HBV C) DMX1KDM MT DTT DMX1KDM MA Inhibitor DMX1KDM RN Safety, pharmacokinetics, and antiviral effects of ABI-H0731, a hepatitis B virus core inhibitor: a randomised, placebo-controlled phase 1 trial. Lancet Gastroenterol Hepatol. 2020 Feb;5(2):152-166. DMX1KDM RU https://pubmed.ncbi.nlm.nih.gov/31711752 DM6X70G DI DM6X70G DM6X70G DN ABI-H2158 DM6X70G MI TTM42UJ DM6X70G MN Hepatitis B virus Capsid protein (HBV C) DM6X70G MT DTT DM6X70G MA Inhibitor DM6X70G RN Clinical pipeline report, company report or official report of Assembly Biosciences. DM6X70G RU https://www.assemblybio.com/pipeline/ DMTCXSG DI DMTCXSG DMTCXSG DN Abituzumab DMTCXSG MI TTT1R2L DMTCXSG MN Integrin alpha-V (ITGAV) DMTCXSG MT DTT DMTCXSG RN Abituzumab combined with cetuximab plus irinotecan versus cetuximab plus irinotecan alone for patients with KRAS wild-type metastatic colorectal cancer: the randomised phase I/II POSEIDON trial. Ann Oncol. 2015 Jan;26(1):132-40. DMTCXSG RU https://pubmed.ncbi.nlm.nih.gov/25319061 DM23UQ9 DI DM23UQ9 DM23UQ9 DN ABT-122 DM23UQ9 MI TTG0MT6 DM23UQ9 MN Interleukin-17 (IL17) DM23UQ9 MT DTT DM23UQ9 MA Modulator DM23UQ9 RN DOI: 10.1136/annrheumdis-2015-eular.4042 DM23UQ9 RU http://ard.bmj.com/content/74/Suppl_2/479.2.abstract DM23UQ9 DI DM23UQ9 DM23UQ9 DN ABT-122 DM23UQ9 MI TTF8CQI DM23UQ9 MN Tumor necrosis factor (TNF) DM23UQ9 MT DTT DM23UQ9 MA Modulator DM23UQ9 RN DOI: 10.1136/annrheumdis-2015-eular.4042 DM23UQ9 RU http://ard.bmj.com/content/74/Suppl_2/479.2.abstract DM2OS51 DI DM2OS51 DM2OS51 DN ABT-126 DM2OS51 MI TTLA931 DM2OS51 MN Neuronal acetylcholine receptor alpha-7 (CHRNA7) DM2OS51 MT DTT DM2OS51 MA Modulator DM2OS51 RN A phase 2 randomized, controlled trial of the alpha7 agonist ABT-126 in mild-to-moderate Alzheimer's dementia. Alzheimer's & Dementia: Translational Research & Clinical Interventions Volume 1, Issue 1, June 2015, Pages 81-90. DM2OS51 RU http://www.sciencedirect.com/science/article/pii/S2352873715000104 DMN3S1B DI DMN3S1B DMN3S1B DN ABT-229 DMN3S1B MI TTQ6VDM DMN3S1B MN Voltage-gated potassium channel Kv11.1 (KCNH2) DMN3S1B MT DTT DMN3S1B MA Inhibitor DMN3S1B RN 9-Dihydroerythromycin ethers as motilin agonists--developing structure-activity relationships for potency and safety. Bioorg Med Chem. 2010 Nov 1;18(21):7651-8. DMN3S1B RU https://pubmed.ncbi.nlm.nih.gov/20869254 DM7X54F DI DM7X54F DM7X54F DN ABT-288 DM7X54F MI TT9JNIC DM7X54F MN Histamine H3 receptor (H3R) DM7X54F MT DTT DM7X54F MA Modulator DM7X54F RN A randomized study of H3 antagonist ABT-288 in mild-to-moderate Alzheimer's dementia.J Alzheimers Dis.2014;42(3):959-71. DM7X54F RU https://www.ncbi.nlm.nih.gov/pubmed/25024314 DM6WN2D DI DM6WN2D DM6WN2D DN ABT-308 DM6WN2D MI TTMPZ7V DM6WN2D MN Interleukin 13 receptor alpha-2 (IL13RA2) DM6WN2D MT DTT DM6WN2D MA Antagonist DM6WN2D RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DM6WN2D RU http://phrma-docs.phrma.org/sites/default/files/pdf/medicines-in-development-drug-list-rare-diseases.pdf DMMZOYN DI DMMZOYN DMMZOYN DN ABT-348 DMMZOYN MI TTPS3C0 DMMZOYN MN Aurora kinase A (AURKA) DMMZOYN MT DTT DMMZOYN MA Modulator DMMZOYN RN Preclinical characterization of ABT-348, a kinase inhibitor targeting the aurora, vascular endothelial growth factor receptor/platelet-derived growth factor receptor, and Src kinase families. J Pharmacol Exp Ther. 2012 Dec;343(3):617-27. DMMZOYN RU https://pubmed.ncbi.nlm.nih.gov/22935731 DMMZOYN DI DMMZOYN DMMZOYN DN ABT-348 DMMZOYN MI TT5LS6T DMMZOYN MN Aurora kinase B (AURKB) DMMZOYN MT DTT DMMZOYN MA Modulator DMMZOYN RN Preclinical characterization of ABT-348, a kinase inhibitor targeting the aurora, vascular endothelial growth factor receptor/platelet-derived growth factor receptor, and Src kinase families. J Pharmacol Exp Ther. 2012 Dec;343(3):617-27. DMMZOYN RU https://pubmed.ncbi.nlm.nih.gov/22935731 DMMZOYN DI DMMZOYN DMMZOYN DN ABT-348 DMMZOYN MI TTLYXIT DMMZOYN MN Aurora kinase C (AURKC) DMMZOYN MT DTT DMMZOYN MA Modulator DMMZOYN RN Preclinical characterization of ABT-348, a kinase inhibitor targeting the aurora, vascular endothelial growth factor receptor/platelet-derived growth factor receptor, and Src kinase families. J Pharmacol Exp Ther. 2012 Dec;343(3):617-27. DMMZOYN RU https://pubmed.ncbi.nlm.nih.gov/22935731 DM7XW5Y DI DM7XW5Y DM7XW5Y DN ABT-384 DM7XW5Y MI DE4LYSA DM7XW5Y MN Cytochrome P450 3A4 (CYP3A4) DM7XW5Y MT DME DM7XW5Y MA Metabolism DM7XW5Y RN Effect of ketoconazole on the pharmacokinetics of the 11beta-hydroxysteroid dehydrogenase type 1 inhibitor ABT-384 and its two active metabolites in healthy volunteers: population analysis of data from a drug-drug interaction study. Drug Metab Dispos. 2013 May;41(5):1035-45. DM7XW5Y RU https://www.ncbi.nlm.nih.gov/pubmed/?term=23431112 DMGUTPN DI DMGUTPN DMGUTPN DN ABT-414 DMGUTPN MI TTGKNB4 DMGUTPN MN Epidermal growth factor receptor (EGFR) DMGUTPN MT DTT DMGUTPN RN Marine-Sourced Anti-Cancer and Cancer Pain Control Agents in Clinical and Late Preclinical Development. Mar Drugs. 2014 January; 12(1): 255-278. DMGUTPN RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3917273/ DMNAU1V DI DMNAU1V DMNAU1V DN ABT-436 DMNAU1V MI TTL9MHW DMNAU1V MN Vasopressin V1b receptor (V1BR) DMNAU1V MT DTT DMNAU1V MA Modulator DMNAU1V RN The vasopressin Avprlb receptor: Molecular and pharmacological studies. Stress. 2011 January; 14(1): 98-115. DMNAU1V RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3016603/ DMFW860 DI DMFW860 DMFW860 DN ABT-450 DMFW860 MI TT5FNQT DMFW860 MN Human immunodeficiency virus Protease (HIV PR) DMFW860 MT DTT DMFW860 MA Inhibitor DMFW860 RN Clinical pipeline report, company report or official report of Abbott Laboratories (2011) DMFW860 RU http://www.abbott.com/index2.htm DMPDVM8 DI DMPDVM8 DMPDVM8 DN ABT-510 DMPDVM8 MI TTKI0H1 DMPDVM8 MN Thrombospondin-1 (THBS1) DMPDVM8 MT DTT DMPDVM8 MA Modulator DMPDVM8 RN A phase II study of ABT-510 (thrombospondin-1 analog) for the treatment of metastatic melanoma. Am J Clin Oncol. 2007 Jun;30(3):303-9. DMPDVM8 RU https://pubmed.ncbi.nlm.nih.gov/17551310 DMEWQ4X DI DMEWQ4X DMEWQ4X DN ABT-639 DMEWQ4X MI TTZPWGN DMEWQ4X MN Voltage-gated calcium channel alpha Cav3.2 (CACNA1H) DMEWQ4X MT DTT DMEWQ4X MA Modulator DMEWQ4X RN Effects of a T-type calcium channel blocker, ABT-639, on spontaneous activity in C-nociceptors in patients with painful diabetic neuropathy: a randomized controlled trial. Pain. 2015 Nov;156(11):2175-83. DMEWQ4X RU https://pubmed.ncbi.nlm.nih.gov/26035253 DMLEO2Z DI DMLEO2Z DMLEO2Z DN ABT-652 DMLEO2Z MI TT9JNIC DMLEO2Z MN Histamine H3 receptor (H3R) DMLEO2Z MT DTT DMLEO2Z MA Modulator DMLEO2Z RN Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800032225) DMLEO2Z RU http://adisinsight.springer.com/drugs/800032225 DMNG35S DI DMNG35S DMNG35S DN ABT-751 DMNG35S MI DED5UR3 DMNG35S MN Sulfotransferase 1B1 (SULT1B1) DMNG35S MT DME DMNG35S MA Metabolism DMNG35S RN Preclinical discovery of candidate genes to guide pharmacogenetics during phase I development: the example of the novel anticancer agent ABT-751. Pharmacogenet Genomics. 2013 Jul;23(7):374-81. DMNG35S RU https://www.ncbi.nlm.nih.gov/pubmed/?term=23670235 DMNG35S DI DMNG35S DMNG35S DN ABT-751 DMNG35S MI TTYFKSZ DMNG35S MN Tubulin beta (TUBB) DMNG35S MT DTT DMNG35S MA Modulator DMNG35S RN Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41. DMNG35S RU https://www.ncbi.nlm.nih.gov/pubmed/15950434 DMNG35S DI DMNG35S DMNG35S DN ABT-751 DMNG35S MI DEYGVN4 DMNG35S MN UDP-glucuronosyltransferase 1A1 (UGT1A1) DMNG35S MT DME DMNG35S MA Metabolism DMNG35S RN Preclinical discovery of candidate genes to guide pharmacogenetics during phase I development: the example of the novel anticancer agent ABT-751. Pharmacogenet Genomics. 2013 Jul;23(7):374-81. DMNG35S RU https://www.ncbi.nlm.nih.gov/pubmed/?term=23670235 DM6PTIX DI DM6PTIX DM6PTIX DN ABT-981 DM6PTIX MI TTPM6HI DM6PTIX MN Interleukin-1 alpha (IL1A) DM6PTIX MT DTT DM6PTIX MA Modulator DM6PTIX RN Generation and characterization of ABT-981, a dual variable domain immunoglobulin (DVD-Ig(TM)) molecule that specifically and potently neutralizes both IL-1alpha and IL-1beta. MAbs. 2015;7(3):605-19. DM6PTIX RU https://pubmed.ncbi.nlm.nih.gov/25764208 DM6PTIX DI DM6PTIX DM6PTIX DN ABT-981 DM6PTIX MI TTRYK0X DM6PTIX MN Interleukin-1 beta (IL1B) DM6PTIX MT DTT DM6PTIX MA Modulator DM6PTIX RN Generation and characterization of ABT-981, a dual variable domain immunoglobulin (DVD-Ig(TM)) molecule that specifically and potently neutralizes both IL-1alpha and IL-1beta. MAbs. 2015;7(3):605-19. DM6PTIX RU https://pubmed.ncbi.nlm.nih.gov/25764208 DM9Y1XB DI DM9Y1XB DM9Y1XB DN ABT-RTA-408 DM9Y1XB MI TTA6ZN2 DM9Y1XB MN Nuclear factor erythroid 2-related factor 2 (Nrf2) DM9Y1XB MT DTT DM9Y1XB MA Modulator DM9Y1XB RN National Cancer Institute Drug Dictionary (drug id 756624). DM9Y1XB RU http://www.cancer.gov/publications/dictionaries/cancer-drug?cdrid=756624 DM91U0R DI DM91U0R DM91U0R DN ABX-EGF DM91U0R MI TTGKNB4 DM91U0R MN Epidermal growth factor receptor (EGFR) DM91U0R MT DTT DM91U0R RN Monoclonal antibodies to target epidermal growth factor receptor-positive tumors: a new paradigm for cancer therapy. Cancer. 2002 Mar 1;94(5):1593-611. DM91U0R RU https://pubmed.ncbi.nlm.nih.gov/11920518 DMCZFMS DI DMCZFMS DMCZFMS DN ABX-IL8 DMCZFMS MI TTCTE1G DMCZFMS MN Interleukin-8 (IL8) DMCZFMS MT DTT DMCZFMS RN Fully humanized neutralizing antibodies to interleukin-8 (ABX-IL8) inhibit angiogenesis, tumor growth, and metastasis of human melanoma. Am J Pathol. 2002 Jul;161(1):125-34. DMCZFMS RU https://pubmed.ncbi.nlm.nih.gov/12107097 DMNVFZA DI DMNVFZA DMNVFZA DN AC-1202 DMNVFZA MI TTNHYJL DMNVFZA MN Ketogenesis (KG) DMNVFZA MT DTT DMNVFZA MA Modulator DMNVFZA RN Study of the ketogenic agent AC-1202 in mild to moderate Alzheimer's disease: a randomized, double-blind, placebo-controlled, multicenter trial. Nutr Metab (Lond). 2009 Aug 10;6:31. DMNVFZA RU https://pubmed.ncbi.nlm.nih.gov/19664276 DMB0TNL DI DMB0TNL DMB0TNL DN AC-201 DMB0TNL MI TTCQIBE DMB0TNL MN Caspase-1 (CASP1) DMB0TNL MT DTT DMB0TNL MA Inhibitor DMB0TNL RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMB0TNL RU http://phrma-docs.phrma.org/files/dmfile/mid-diabetes-drug-list.pdf DMB0TNL DI DMB0TNL DMB0TNL DN AC-201 DMB0TNL MI TTRYK0X DMB0TNL MN Interleukin-1 beta (IL1B) DMB0TNL MT DTT DMB0TNL MA Inhibitor DMB0TNL RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMB0TNL RU http://phrma-docs.phrma.org/files/dmfile/mid-diabetes-drug-list.pdf DM3TUBR DI DM3TUBR DM3TUBR DN Acalabrutinib DM3TUBR MI TTOWPER DM3TUBR MN HUMAN bruton tyrosine kinase (BTK) DM3TUBR MT DTT DM3TUBR MA Inhibitor DM3TUBR RN AstraZeneca initiates CALAVI clinical trial with Calquence against COVID-19 DM3TUBR RU https://www.astrazeneca.com/media-centre/press-releases/2020/astrazeneca-initiates-calavi-clinical-trial-with-calquence-against-covid-19.html DM0FGDO DI DM0FGDO DM0FGDO DN ACCLAIM DM0FGDO MI TTCM4B3 DM0FGDO MN Nitric-oxide synthase endothelial (NOS3) DM0FGDO MT DTT DM0FGDO MA Stimulator DM0FGDO RN CenterWatch. Drugs in Clinical Trials Database. CenterWatch. 2008. DM0FGDO RU http://www.centerwatch.com/ DMZ8PY0 DI DMZ8PY0 DMZ8PY0 DN ACE-031 DMZ8PY0 MI TTSWPH8 DMZ8PY0 MN Growth/differentiation factor 8 (GDF-8) DMZ8PY0 MT DTT DMZ8PY0 MA Inhibitor DMZ8PY0 RN A single ascending-dose study of muscle regulator ACE-031 in healthy volunteers. Muscle Nerve. 2013 Mar;47(3):416-23. DMZ8PY0 RU https://pubmed.ncbi.nlm.nih.gov/23169607 DMIVUFL DI DMIVUFL DMIVUFL DN ACH-1625 DMIVUFL MI TT5FNQT DMIVUFL MN Human immunodeficiency virus Protease (HIV PR) DMIVUFL MT DTT DMIVUFL MA Inhibitor DMIVUFL RN Clinical pipeline report, company report or official report of Achillion (2011). DMIVUFL RU http://www.achillion.com/main.aspx?pn=ProductPipeline&fl=l DM0RPY5 DI DM0RPY5 DM0RPY5 DN ACH-3102 DM0RPY5 MI TTCJ2X8 DM0RPY5 MN Hepatitis C virus Non-structural 5A (HCV NS5A) DM0RPY5 MT DTT DM0RPY5 MA Modulator DM0RPY5 RN Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41. DM0RPY5 RU https://www.ncbi.nlm.nih.gov/pubmed/15950434 DMLVCZR DI DMLVCZR DMLVCZR DN ACH-4471 DMLVCZR MI TT8D13I DMLVCZR MN Complement factor D (CFD) DMLVCZR MT DTT DMLVCZR MA Inhibitor DMLVCZR RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMLVCZR RU http://phrma-docs.phrma.org/files/dmfile/medicines-in-development-drug-list-autoimmune-diseases.pdf DMPR8E9 DI DMPR8E9 DMPR8E9 DN ACP-001 DMPR8E9 MI TTT3YKH DMPR8E9 MN Somatotropin (GH1) DMPR8E9 MT DTT DMPR8E9 MA Modulator DMPR8E9 RN ClinicalTrials.gov (NCT01947907) Safety, PK/PD and Efficacy of ACP-001 Weekly Versus Daily hGH in Children With Growth Hormone Deficiency (GHD). U.S. National Institutes of Health. DMPR8E9 RU https://clinicaltrials.gov/ct2/show/NCT01947907 DMMG61B DI DMMG61B DMMG61B DN ACT-GRO-777 DMMG61B MI TTCSZH7 DMMG61B MN Nucleolin (NCL) DMMG61B MT DTT DMMG61B RN Nucleic Acid Aptamers as Potential Therapeutic and Diagnostic Agents for Lymphoma. J Cancer Ther. 2013 June 1; 4(4): 872-890. DMMG61B RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4104705/ DMKBIPR DI DMKBIPR DMKBIPR DN Actimab-A DMKBIPR MI TTJVYO3 DMKBIPR MN Myeloid cell surface antigen CD33 (CD33) DMKBIPR MT DTT DMKBIPR MA Inhibitor DMKBIPR RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMKBIPR RU http://phrma-docs.phrma.org/files/dmfile/MID_Immuno-Oncology-2017_Drug-List1.pdf DM9GRTK DI DM9GRTK DM9GRTK DN ACYLINE DM9GRTK MI TT8R70G DM9GRTK MN Gonadotropin-releasing hormone receptor (GNRHR) DM9GRTK MT DTT DM9GRTK MA Inhibitor DM9GRTK RN Structure-activity relationship studies of gonadotropin-releasing hormone antagonists containing S-aryl/alkyl norcysteines and their oxidized deriv... J Med Chem. 2007 May 3;50(9):2067-77. DM9GRTK RU https://pubmed.ncbi.nlm.nih.gov/17402723 DMLV9GS DI DMLV9GS DMLV9GS DN AD04 DMLV9GS MI TTNXLKE DMLV9GS MN 5-HT 3 receptor (5HT3R) DMLV9GS MT DTT DMLV9GS MA Antagonist DMLV9GS RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMLV9GS RU http://phrma-docs.phrma.org/files/dmfile/MID_Mental-Illness-2017-Drug-List_Final.pdf DMMFLXN DI DMMFLXN DMMFLXN DN AD-452 DMMFLXN MI TTXM6JN DMMFLXN MN Cytokine receptor unspecific (CRF) DMMFLXN MT DTT DMMFLXN MA Modulator DMMFLXN RN Detection of apoptosis by RT-PCR array in mefloquine-induced cochlear damage. Journal of Otology Volume 6, Issue 1, June 2011, Pages 1-9. DMMFLXN RU http://www.sciencedirect.com/science/article/pii/S1672293011500017 DM8GHIX DI DM8GHIX DM8GHIX DN ADC-3680 DM8GHIX MI TTQDMX5 DM8GHIX MN Prostaglandin D2 receptor 2 (PTGDR2) DM8GHIX MT DTT DM8GHIX MA Antagonist DM8GHIX RN Update on the status of DP2 receptor antagonists; from proof of concept through clinical failures to promising new drugs. Expert Opin Investig Drugs. 2014 Jan;23(1):55-66. DM8GHIX RU https://pubmed.ncbi.nlm.nih.gov/24073896 DM821BS DI DM821BS DM821BS DN Adipiplon DM821BS MI TT37EDJ DM821BS MN GABA(A) receptor alpha-3 (GABRA3) DM821BS MT DTT DM821BS MA Modulator DM821BS RN Discriminative stimulus properties of GABAA receptor positive allosteric modulators TPA023, ocinaplon and NG2-73 in rats trained to discriminate chlordiazepoxide or zolpidem. Eur J Pharmacol. 2011 Oct 1;668(1-2):190-3. DM821BS RU https://pubmed.ncbi.nlm.nih.gov/21762686 DMMUPTN DI DMMUPTN DMMUPTN DN ADL-5747 DMMUPTN MI TT27RFC DMMUPTN MN Opioid receptor delta (OPRD1) DMMUPTN MT DTT DMMUPTN MA Agonist DMMUPTN RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 317). DMMUPTN RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=317 DMDQH9A DI DMDQH9A DMDQH9A DN ADL-5859 DMDQH9A MI TT27RFC DMDQH9A MN Opioid receptor delta (OPRD1) DMDQH9A MT DTT DMDQH9A MA Agonist DMDQH9A RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 317). DMDQH9A RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=317 DM819CO DI DM819CO DM819CO DN ADMVA DM819CO MI TTFBNVI DM819CO MN Aldose reductase (AKR1B1) DM819CO MT DTT DM819CO RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2768). DM819CO RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2768 DMJSWXL DI DMJSWXL DMJSWXL DN Ad-p53 DMJSWXL MI TT7SBF5 DMJSWXL MN Cellular tumor antigen p53 (TP53) DMJSWXL MT DTT DMJSWXL MA Modulator DMJSWXL RN Assessment of p53 gene transfer and biological activities in a clinical study of adenovirus-p53 gene therapy for recurrent ovarian cancer. Cancer Gene Ther. 2003 Mar;10(3):224-38. DMJSWXL RU https://pubmed.ncbi.nlm.nih.gov/12637944 DMRYH3M DI DMRYH3M DMRYH3M DN ADP-A2M4 DMRYH3M MI TT9EQUY DMRYH3M MN Melanoma-associated antigen 4 (MAGEA4) DMRYH3M MT DTT DMRYH3M RN Clinical pipeline report, company report or official report of Adaptimmune. DMRYH3M RU https://www.adaptimmune.com/pipeline/adp-a2m4 DME384W DI DME384W DME384W DN AdPEDR DME384W MI TTR59S1 DME384W MN Pigment epithelium-derived factor (SERPINF1) DME384W MT DTT DME384W MA Inhibitor DME384W RN Future pharmacological treatment options for nonexudative and exudative age-related macular degeneration. Expert Opin Emerg Drugs. 2005 Feb;10(1):119-35. DME384W RU https://pubmed.ncbi.nlm.nih.gov/15757408 DMCNTFW DI DMCNTFW DMCNTFW DN Ad-RTS-hIL-12 DMCNTFW MI TTG68FB DMCNTFW MN Interleukine 12 (IL-12) DMCNTFW MT DTT DMCNTFW MA Replacement DMCNTFW RN Clinical pipeline report, company report or official report of Ziopharm Oncology. DMCNTFW RU https://ziopharm.com/controlled-il-12/ DMM6B2Y DI DMM6B2Y DMM6B2Y DN ADU- S100 DMM6B2Y MI TTT402Y DMM6B2Y MN Stimulator of interferon genes protein (TMEM173) DMM6B2Y MT DTT DMM6B2Y MA Agonist DMM6B2Y RN Magnitude of Therapeutic STING Activation Determines CD8 + T Cell-Mediated Anti-tumor Immunity. Cell Rep. 2018 Dec 11;25(11):3074-3085.e5. DMM6B2Y RU https://pubmed.ncbi.nlm.nih.gov/30540940 DM8HBUI DI DM8HBUI DM8HBUI DN ADU-S100 DM8HBUI MI TTT402Y DM8HBUI MN Stimulator of interferon genes protein (TMEM173) DM8HBUI MT DTT DM8HBUI MA Activator DM8HBUI RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DM8HBUI RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DMGVKHQ DI DMGVKHQ DMGVKHQ DN ADX10059 DMGVKHQ MI TTHS256 DMGVKHQ MN Metabotropic glutamate receptor 5 (mGluR5) DMGVKHQ MT DTT DMGVKHQ MA Modulator DMGVKHQ RN A proof-of-concept study evaluating the effect of ADX10059, a metabotropic glutamate receptor-5 negative allosteric modulator, on acid exposure and... Gut. 2009 Sep;58(9):1192-9. DMGVKHQ RU https://pubmed.ncbi.nlm.nih.gov/19460767 DMC8NAO DI DMC8NAO DMC8NAO DN ADXS-HPV DMC8NAO MI TT3CPZW DMC8NAO MN Human papillomavirus protein E7 (HPV E7) DMC8NAO MT DTT DMC8NAO RN ADXS11-001 immunotherapy targeting HPV-E7: updated survival and safety data from a phase 2 study in Indian women with recurrent/refractory cervical cancer. Journal for ImmunoTherapy of Cancer, 2013, 1(Suppl 1):P231. DMC8NAO RU http://www.immunotherapyofcancer.org/content/1/S1/P231 DMJVN89 DI DMJVN89 DMJVN89 DN AEB07 DMJVN89 MI TTYVX59 DMJVN89 MN Protein kinase C (PRKC) DMJVN89 MT DTT DMJVN89 MA Inhibitor DMJVN89 RN What's next in the pipeline. Am J Transplant. 2008 Oct;8(10):1972-81. DMJVN89 RU https://pubmed.ncbi.nlm.nih.gov/18828764 DMQ1GH4 DI DMQ1GH4 DMQ1GH4 DN AEF0117 DMQ1GH4 MI TT6OEDT DMQ1GH4 MN Cannabinoid receptor 1 (CB1) DMQ1GH4 MT DTT DMQ1GH4 MA Antagonist DMQ1GH4 RN Clinical pipeline report, company report or official report of Affimed Therapeutics. DMQ1GH4 RU https://brain.labex.u-bordeaux.fr/Actions/Focus/CannaPreg-i6901.html DMSBLOU DI DMSBLOU DMSBLOU DN AEG-33773 DMSBLOU MI TTHYBIX DMSBLOU MN Heat shock protein 70 (HSP70) DMSBLOU MT DTT DMSBLOU MA Inhibitor DMSBLOU RN Mitogen-activated protein kinase kinase kinase 12 (MAP3K12; DLK); c-jun N-terminal kinase (JNK). SciBX 2(11); doi:10.1038/scibx.2009.462. March 19 2009 DMSBLOU RU http://www.nature.com/scibx/journal/v2/n11/full/scibx.2009.462.html DMI5TXZ DI DMI5TXZ DMI5TXZ DN AEM-28 DMI5TXZ MI TTKS9CB DMI5TXZ MN Apolipoprotein E (APOE) DMI5TXZ MT DTT DMI5TXZ MA Modulator DMI5TXZ RN Clinical pipeline report, company report or official report of LipimetiX. DMI5TXZ RU http://www.lipimetix.com/technology.html DMNO7BC DI DMNO7BC DMNO7BC DN AeroLEF DMNO7BC MI TTN4QDT DMNO7BC MN Opioid receptor (OPR) DMNO7BC MT DTT DMNO7BC MA Agonist DMNO7BC RN Current Research on Opioid Receptor Function. Curr Drug Targets. 2012 February; 13(2): 230-246. DMNO7BC RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3371376/ DMFO2G5 DI DMFO2G5 DMFO2G5 DN Afabicin DMFO2G5 MI TTZBRVL DMFO2G5 MN Staphylococcus Enoyl ACP reductase (Stap-coc fabI) DMFO2G5 MT DTT DMFO2G5 MA Inhibitor DMFO2G5 RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMFO2G5 RU http://phrma-docs.phrma.org/files/dmfile/MID_Skin_Diseases_2018_9_FINAL.pdf DMFORDT DI DMFORDT DMFORDT DN Afimoxifene DMFORDT MI TTZAYWL DMFORDT MN Estrogen receptor (ESR) DMFORDT MT DTT DMFORDT MA Modulator DMFORDT RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 620). DMFORDT RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=620 DMFORDT DI DMFORDT DMFORDT DN Afimoxifene DMFORDT MI DTUGYRD DMFORDT MN P-glycoprotein 1 (ABCB1) DMFORDT MT DTP DMFORDT MA Substrate DMFORDT RN Antiestrogens and steroid hormones: substrates of the human P-glycoprotein. Biochem Pharmacol. 1994 Jul 19;48(2):287-92. DMFORDT RU http://www.ncbi.nlm.nih.gov/pubmed/7914405 DMFORDT DI DMFORDT DMFORDT DN Afimoxifene DMFORDT MI DEYGVN4 DMFORDT MN UDP-glucuronosyltransferase 1A1 (UGT1A1) DMFORDT MT DME DMFORDT MA Metabolism DMFORDT RN Glucuronidation of active tamoxifen metabolites by the human UDP glucuronosyltransferases. Drug Metab Dispos. 2007 Nov;35(11):2006-14. DMFORDT RU https://www.ncbi.nlm.nih.gov/pubmed/?term=17664247 DMFORDT DI DMFORDT DMFORDT DN Afimoxifene DMFORDT MI DE2GB8N DMFORDT MN UDP-glucuronosyltransferase 1A8 (UGT1A8) DMFORDT MT DME DMFORDT MA Metabolism DMFORDT RN Glucuronidation of active tamoxifen metabolites by the human UDP glucuronosyltransferases. Drug Metab Dispos. 2007 Nov;35(11):2006-14. DMFORDT RU https://www.ncbi.nlm.nih.gov/pubmed/?term=17664247 DMN45IC DI DMN45IC DMN45IC DN AFM13 DMN45IC MI TTIFOC0 DMN45IC MN Immunoglobulin gamma Fc receptor IIIA (FCGR3A) DMN45IC MT DTT DMN45IC RN Clinical pipeline report, company report or official report of Affimed Therapeutics. DMN45IC RU https://www.affimed.com/rock-platform/pipeline/ DMN45IC DI DMN45IC DMN45IC DN AFM13 DMN45IC MI TT2GM5R DMN45IC MN Lymphocyte activation antigen CD30 (TNFRSF8) DMN45IC MT DTT DMN45IC RN Clinical pipeline report, company report or official report of Affimed Therapeutics. DMN45IC RU https://www.affimed.com/rock-platform/pipeline/ DMTFE9Y DI DMTFE9Y DMTFE9Y DN AFN-1252 DMTFE9Y MI TTZBRVL DMTFE9Y MN Staphylococcus Enoyl ACP reductase (Stap-coc fabI) DMTFE9Y MT DTT DMTFE9Y MA Inhibitor DMTFE9Y RN Activity of AFN-1252, a novel FabI inhibitor, against Staphylococcus aureus in an in vitro pharmacodynamic model simulating human pharmacokinetics. J Chemother. 2013 Feb;25(1):32-5. DMTFE9Y RU https://pubmed.ncbi.nlm.nih.gov/23433442 DM6AJKC DI DM6AJKC DM6AJKC DN AFN-1720 DM6AJKC MI TTVTX4N DM6AJKC MN Bacterial Fatty acid synthetase I (Bact inhA) DM6AJKC MT DTT DM6AJKC MA Inhibitor DM6AJKC RN Affinium Pharmaceuticals Announces the Initiation of a Phase 1 Intravenous Clinical Trial of a New Antibiotic Prodrug, and the Closing of a Follow-on Financing Round. PR Newswire Sep. 4, 2013 10:16 PM. DM6AJKC RU http://www.virtualizationconference.com/node/2779672 DM1FJ2B DI DM1FJ2B DM1FJ2B DN AFP464 DM1FJ2B MI TT2QPV9 DM1FJ2B MN Aryl hydrocarbon receptor signaling pathway (AhR pathway) DM1FJ2B MT DTT DM1FJ2B MA Suppressor DM1FJ2B RN Clinical pipeline report, company report or official report of AFP464. DM1FJ2B RU https://www.cancer.gov/publications/dictionaries/cancer-drug/def/afp464 DMD3XMG DI DMD3XMG DMD3XMG DN AFTVac DMD3XMG MI TT6MP2Z DMD3XMG MN GMCSFR-alpha (CSF2RA) DMD3XMG MT DTT DMD3XMG RN Phase II randomized trial of autologous formalin-fixed tumor vaccine for postsurgical recurrence of hepatocellular carcinoma. Clin Cancer Res. 2004 Mar 1;10(5):1574-9. DMD3XMG RU https://pubmed.ncbi.nlm.nih.gov/15014006 DMD3XMG DI DMD3XMG DMD3XMG DN AFTVac DMD3XMG MI TT9721Y DMD3XMG MN Interleukin 2 receptor beta (IL2RB) DMD3XMG MT DTT DMD3XMG RN Phase II randomized trial of autologous formalin-fixed tumor vaccine for postsurgical recurrence of hepatocellular carcinoma. Clin Cancer Res. 2004 Mar 1;10(5):1574-9. DMD3XMG RU https://pubmed.ncbi.nlm.nih.gov/15014006 DMA9FKY DI DMA9FKY DMA9FKY DN AG140699 DMA9FKY MI TTVDSZ0 DMA9FKY MN Poly [ADP-ribose] polymerase 1 (PARP1) DMA9FKY MT DTT DMA9FKY MA Inhibitor DMA9FKY RN Poly(ADP-ribose) polymerase and the therapeutic effects of its inhibitors. Nat Rev Drug Discov. 2005 May;4(5):421-40. DMA9FKY RU https://pubmed.ncbi.nlm.nih.gov/15864271 DMNQ5T2 DI DMNQ5T2 DMNQ5T2 DN AG-858 DMNQ5T2 MI TTHYBIX DMNQ5T2 MN Heat shock protein 70 (HSP70) DMNQ5T2 MT DTT DMNQ5T2 RN Preparation of a Heat Shock Proteins 70-based Vaccine from DC-tumor fusion cells. Methods Mol Biol. 2011; 787: 255-265. DMNQ5T2 RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4088345/ DMPO7UG DI DMPO7UG DMPO7UG DN AGEN2034 DMPO7UG MI TTNBFWK DMPO7UG MN Programmed cell death protein 1 (PD-1) DMPO7UG MT DTT DMPO7UG MA Inhibitor DMPO7UG RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMPO7UG RU http://phrma-docs.phrma.org/files/dmfile/MID_Immuno-Oncology-2017_Drug-List1.pdf DMP5Y1A DI DMP5Y1A DMP5Y1A DN AGN-199981 DMP5Y1A MI TTWM4TY DMP5Y1A MN Adrenergic receptor alpha-2B (ADRA2B) DMP5Y1A MT DTT DMP5Y1A MA Agonist DMP5Y1A RN Emerging drugs in neuropathic pain. Expert Opin Emerg Drugs. 2007 Mar;12(1):113-26. DMP5Y1A RU https://pubmed.ncbi.nlm.nih.gov/17355217 DM4KOAC DI DM4KOAC DM4KOAC DN AGN-241751 DM4KOAC MI TT9IK2Z DM4KOAC MN N-methyl-D-aspartate receptor (NMDAR) DM4KOAC MT DTT DM4KOAC MA Modulator DM4KOAC RN Positive modulation of NMDA receptors by AGN-241751 exerts rapid antidepressant-like effects via excitatory neurons. Neuropsychopharmacology. 2021 Mar;46(4):799-808. DM4KOAC RU https://pubmed.ncbi.nlm.nih.gov/33059355 DMLQRFO DI DMLQRFO DMLQRFO DN AGN-2979 DMLQRFO MI TTZSJHV DMLQRFO MN Tryptophan 5-hydroxylase 1 (TPH1) DMLQRFO MT DTT DMLQRFO MA Modulator DMLQRFO RN Antidepressant-like action of AGN 2979, a tryptophan hydroxylase activation inhibitor, in a chronic mild stress model of depression in rats. Eur Neuropsychopharmacol. 2001 Oct;11(5):351-7. DMLQRFO RU https://pubmed.ncbi.nlm.nih.gov/11597821 DMMGAUK DI DMMGAUK DMMGAUK DN AGN-XX/YY DMMGAUK MI TT2NUT5 DMMGAUK MN Adrenergic receptor alpha-2C (ADRA2C) DMMGAUK MT DTT DMMGAUK MA Agonist DMMGAUK RN Patent WO2008058220 A2. DMMGAUK RU http://www.google.com/patents/WO2008058220A2?cl=en DM2POHA DI DM2POHA DM2POHA DN AGS-16C3F DM2POHA MI TTD4TKP DM2POHA MN Phosphodiesterase I beta (ENPP3) DM2POHA MT DTT DM2POHA MA Inhibitor DM2POHA RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DM2POHA RU http://phrma-docs.phrma.org/files/dmfile/MID_Immuno-Oncology-2017_Drug-List1.pdf DMMKASG DI DMMKASG DMMKASG DN AGTC-0106 DMMKASG MI TTA7UJC DMMKASG MN Alpha-1-antitrypsin (SERPINA1) DMMKASG MT DTT DMMKASG MA Modulator DMMKASG RN First gene therapy nears landmark European market authorization. Nat Biotechnol. 2012 Sep;30(9):807-9. DMMKASG RU https://pubmed.ncbi.nlm.nih.gov/22965030 DMXJ8Z4 DI DMXJ8Z4 DMXJ8Z4 DN AK104 DMXJ8Z4 MI TTI2S1D DMXJ8Z4 MN Cytotoxic T-lymphocyte protein 4 (CTLA-4) DMXJ8Z4 MT DTT DMXJ8Z4 MA Inhibitor DMXJ8Z4 RN Clinical pipeline report, company report or official report of Akeso Biopharma. DMXJ8Z4 RU https://akesobio-umb.azurewebsites.net/en/rd-and-science/pipelines/ DMXJ8Z4 DI DMXJ8Z4 DMXJ8Z4 DN AK104 DMXJ8Z4 MI TTNBFWK DMXJ8Z4 MN Programmed cell death protein 1 (PD-1) DMXJ8Z4 MT DTT DMXJ8Z4 MA Inhibitor DMXJ8Z4 RN Clinical pipeline report, company report or official report of Akeso Biopharma. DMXJ8Z4 RU https://akesobio-umb.azurewebsites.net/en/rd-and-science/pipelines/ DMKNRYH DI DMKNRYH DMKNRYH DN AKB-9778 DMKNRYH MI TT9VGXW DMKNRYH MN Angiopoietin 1 receptor (TEK) DMKNRYH MT DTT DMKNRYH MA Activator DMKNRYH RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMKNRYH RU http://phrma-docs.phrma.org/files/dmfile/mid-diabetes-drug-list.pdf DMKNRYH DI DMKNRYH DMKNRYH DN AKB-9778 DMKNRYH MI TT64I9Q DMKNRYH MN Protein tyrosine phosphatase beta (PTPRB) DMKNRYH MT DTT DMKNRYH MA Modulator DMKNRYH RN Effects of vascular-endothelial protein tyrosine phosphatase inhibition on breast cancer vasculature and metastatic progression.J Natl Cancer Inst.2013 Aug 21;105(16):1188-201. DMKNRYH RU https://www.ncbi.nlm.nih.gov/pubmed/23899555 DMR8W7Y DI DMR8W7Y DMR8W7Y DN AKCEA-ANGPTL3-LRX DMR8W7Y MI TTUO98L DMR8W7Y MN Angiopoietin-related protein 3 (ANGPTL3) DMR8W7Y MT DTT DMR8W7Y MA Inhibitor DMR8W7Y RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMR8W7Y RU http://phrma-docs.phrma.org/files/dmfile/2018_Heart-Disease-and-Stroke_MID-Drug-List.pdf DMCTWIB DI DMCTWIB DMCTWIB DN AL102 DMCTWIB MI TT9W8GU DMCTWIB MN Gamma-secretase (GS) DMCTWIB MT DTT DMCTWIB MA Inhibitor DMCTWIB RN Clinical pipeline report, company report or official report of Ayala Pharmaceuticals. DMCTWIB RU https://www.ayalapharma.com/pipeline/investigational-therapies-al101-and-al102 DM3P91Z DI DM3P91Z DM3P91Z DN Alacizumab pegol DM3P91Z MI TTUTJGQ DM3P91Z MN Vascular endothelial growth factor receptor 2 (KDR) DM3P91Z MT DTT DM3P91Z RN Phase I evaluation of CDP791, a PEGylated di-Fab' conjugate that binds vascular endothelial growth factor receptor 2. Clin Cancer Res. 2007 Dec 1;13(23):7113-8. DM3P91Z RU https://pubmed.ncbi.nlm.nih.gov/18056191 DM2U530 DI DM2U530 DM2U530 DN ALD-401 DM2U530 MI TTFLN4T DM2U530 MN Mitochondrial aldehyde dehydrogenase (ALDH2) DM2U530 MT DTT DM2U530 MA Modulator DM2U530 RN A novel aldehyde dehydrogenase-3 activator leads to adult salivary stem cell enrichment in vivo. Clin Cancer Res. 2011 Dec 1;17(23):7265-72. DM2U530 RU https://pubmed.ncbi.nlm.nih.gov/21998334 DM6RBYT DI DM6RBYT DM6RBYT DN ALD-403 DM6RBYT MI TTAFORY DM6RBYT MN Calcitonin gene-related peptide (CALC) DM6RBYT MT DTT DM6RBYT MA Modulator DM6RBYT RN Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41. DM6RBYT RU https://www.ncbi.nlm.nih.gov/pubmed/15950434 DMPWSBL DI DMPWSBL DMPWSBL DN ALD-518 DMPWSBL MI TTT1V78 DMPWSBL MN Interleukin-6 (IL6) DMPWSBL MT DTT DMPWSBL MA Modulator DMPWSBL RN Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41. DMPWSBL RU https://www.ncbi.nlm.nih.gov/pubmed/15950434 DMUA0XC DI DMUA0XC DMUA0XC DN ALF-5755 DMUA0XC MI TTL4H8N DMUA0XC MN Regenerating human pro-islet peptide (REG3A) DMUA0XC MT DTT DMUA0XC MA Modulator DMUA0XC RN HIP/PAP prevents excitotoxic neuronal death and promotes plasticity. Ann Clin Transl Neurol. 2014 October; 1(10): 739-754. DMUA0XC RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4241802/ DMR2YPF DI DMR2YPF DMR2YPF DN ALG-1001 DMR2YPF MI TT9HKJA DMR2YPF MN Vascular endothelial growth factor (VEGF) DMR2YPF MT DTT DMR2YPF MA Modulator DMR2YPF RN Future therapies of wet age-related macular degeneration. J Ophthalmol. 2015;2015:138070. DMR2YPF RU https://pubmed.ncbi.nlm.nih.gov/25802751 DME3ZYC DI DME3ZYC DME3ZYC DN ALKS 4230 DME3ZYC MI TTAJU0S DME3ZYC MN Interleukin 2 receptor (IL2R) DME3ZYC MT DTT DME3ZYC MA Agonist DME3ZYC RN ALKS 4230: a novel engineered IL-2 fusion protein with an improved cellular selectivity profile for cancer immunotherapy. J Immunother Cancer. 2020 Apr;8(1):e000673. DME3ZYC RU https://pubmed.ncbi.nlm.nih.gov/32317293 DMF3QN1 DI DMF3QN1 DMF3QN1 DN ALKS33 DMF3QN1 MI TTKWM86 DMF3QN1 MN Opioid receptor mu (MOP) DMF3QN1 MT DTT DMF3QN1 MA Inhibitor DMF3QN1 RN Syntheses of novel high affinity ligands for opioid receptors. Bioorg Med Chem Lett. 2009 Apr 15;19(8):2289-94. DMF3QN1 RU https://pubmed.ncbi.nlm.nih.gov/19282177 DMWYMJN DI DMWYMJN DMWYMJN DN ALN-CC5 DMWYMJN MI TT2LJRF DMWYMJN MN C5 messenger RNA (C5 mRNA) DMWYMJN MT DTT DMWYMJN MA Inhibitor DMWYMJN RN Investigational RNAi Therapeutic Targeting C5 Is Efficacious in Pre-clinical Models of Myasthenia Gravis. Mol Ther Methods Clin Dev. 2019 May 10;13:484-492. DMWYMJN RU https://pubmed.ncbi.nlm.nih.gov/31193726 DMEYNQA DI DMEYNQA DMEYNQA DN ALN-RSV01 DMEYNQA MI TTWSF5D DMEYNQA MN HRSV Nucleoprotein messenger RNA (HRSV N mRNA) DMEYNQA MT DTT DMEYNQA MA Inhibitor DMEYNQA RN Evaluation of the safety, tolerability and pharmacokinetics of ALN-RSV01, a novel RNAi antiviral therapeutic directed against respiratory syncytial virus (RSV). Antiviral Res. 2008 Mar;77(3):225-31. DMEYNQA RU https://pubmed.ncbi.nlm.nih.gov/18242722 DMJPV5X DI DMJPV5X DMJPV5X DN Alovudine DMJPV5X MI TT84ETX DMJPV5X MN Human immunodeficiency virus Reverse transcriptase (HIV RT) DMJPV5X MT DTT DMJPV5X MA Modulator DMJPV5X RN Multiple-dose pharmacokinetics of apricitabine, a novel nucleoside reverse transcriptase inhibitor, in patients with HIV-1 infection. Clin Drug Investig. 2008;28(2):129-38. DMJPV5X RU https://www.ncbi.nlm.nih.gov/pubmed/18211121 DM5EFXZ DI DM5EFXZ DM5EFXZ DN Alpha-1 antitrypsin DM5EFXZ MI TT2WR1T DM5EFXZ MN Cationic trypsinogen (PRSS1) DM5EFXZ MT DTT DM5EFXZ MA Modulator DM5EFXZ RN US patent application no. 2012,0251,516, PHARMACEUTICAL COMPOSITION FOR TREATING CANCER COMPRISING TRYPSINOGEN AND/OR CHYMOTRYPSINOGEN AND AN ACTIVE AGENT SELECTED FROM A SELENIUM COMPOUND, A VANILLOID COMPOUND AND A CYTOPLASMIC GLYCOLYSIS REDUCTION AGENT. DM5EFXZ RU http://www.patentbuddy.com/Patent/20120251516?ft=true&sr=true DMLBWT1 DI DMLBWT1 DMLBWT1 DN ALRN-6924 DMLBWT1 MI TT9OUDQ DMLBWT1 MN p53-binding protein Mdm4 (MDM4) DMLBWT1 MT DTT DMLBWT1 MA Inhibitor DMLBWT1 RN Anti-ageing pipeline starts to mature.Nat Rev Drug Discov. 2018 Sep;17(9):609-612. DMLBWT1 RU https://pubmed.ncbi.nlm.nih.gov/30072728 DMLBWT1 DI DMLBWT1 DMLBWT1 DN ALRN-6924 DMLBWT1 MI TT08GJW DMLBWT1 MN Ubiquitin-protein ligase E3 Mdm2 (MDM2) DMLBWT1 MT DTT DMLBWT1 MA Antagonist DMLBWT1 RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMLBWT1 RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DM9KL7P DI DM9KL7P DM9KL7P DN ALT-801 DM9KL7P MI TT7SBF5 DM9KL7P MN Cellular tumor antigen p53 (TP53) DM9KL7P MT DTT DM9KL7P MA Immunomodulator (Immunostimulant) DM9KL7P RN Phase I trial of ALT-801, an interleukin-2/T-cell receptor fusion protein targeting p53 (aa264-272)/HLA-A*0201 complex, in patients with advanced malignancies. Clin Cancer Res. 2011 Dec 15;17(24):7765-75. DM9KL7P RU https://pubmed.ncbi.nlm.nih.gov/21994418 DMK3U1X DI DMK3U1X DMK3U1X DN ALT-803 DMK3U1X MI TTGN89I DMK3U1X MN Interleukin 15 receptor alpha (IL15RA) DMK3U1X MT DTT DMK3U1X MA Agonist DMK3U1X RN Efficacy and mechanism-of-action of a novel superagonist interleukin-15: interleukin-15 receptor alphaSu/Fc fusion complex in syngeneic murine models of multiple myeloma. Cancer Res. 2013 May 15;73(10):3075-86. DMK3U1X RU https://pubmed.ncbi.nlm.nih.gov/23644531 DMGJ71F DI DMGJ71F DMGJ71F DN ALT-836 DMGJ71F MI TT38MDJ DMGJ71F MN Tissue factor (F3) DMGJ71F MT DTT DMGJ71F MA Inhibitor DMGJ71F RN ImmunoPET of tissue factor expression in triple-negative breast cancer with a radiolabeled antibody Fab fragment. Eur J Nucl Med Mol Imaging. 2015 Jul;42(8):1295-303. DMGJ71F RU https://pubmed.ncbi.nlm.nih.gov/25801992 DMLSK01 DI DMLSK01 DMLSK01 DN Altrakincept DMLSK01 MI TTDWHC3 DMLSK01 MN Interleukin 4 receptor alpha (IL4R) DMLSK01 MT DTT DMLSK01 MA Modulator DMLSK01 RN The potential of biologics for the treatment of asthma. Nat Rev Drug Discov. 2012 Dec;11(12):958-72. DMLSK01 RU https://www.ncbi.nlm.nih.gov/pubmed/23197041 DMXSFA0 DI DMXSFA0 DMXSFA0 DN ALV-003 DMXSFA0 MI TTNGKET DMXSFA0 MN Prolyl endopeptidase (PREP) DMXSFA0 MT DTT DMXSFA0 MA Modulator DMXSFA0 RN The effects of ALV003 pre-digestion of gluten on immune response and symptoms in celiac disease in vivo. Clin Immunol. 2010 Mar;134(3):289-95. DMXSFA0 RU https://pubmed.ncbi.nlm.nih.gov/19942485 DMO1VHC DI DMO1VHC DMO1VHC DN ALX-0061 DMO1VHC MI TT0E5SK DMO1VHC MN Interleukin 6 receptor (IL6R) DMO1VHC MT DTT DMO1VHC RN The preclinical pharmacology of the high affinity anti-IL-6R Nanobody ALX-0061 supports its clinical development in rheumatoid arthritis. Arthritis Res Ther. 2015 May 20;17:135. DMO1VHC RU https://pubmed.ncbi.nlm.nih.gov/25994180 DMCAFXM DI DMCAFXM DMCAFXM DN ALX-101 DMCAFXM MI TTM1EQF DMCAFXM MN Oxysterols receptor LXR (NR1H) DMCAFXM MT DTT DMCAFXM MA Agonist DMCAFXM RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMCAFXM RU http://phrma-docs.phrma.org/files/dmfile/MID_Skin_Diseases_2018_9_FINAL.pdf DMV934L DI DMV934L DMV934L DN ALX-40-4C DMV934L MI TTT3ZC9 DMV934L MN Human immunodeficiency virus Tat protein (HIV tat) DMV934L MT DTT DMV934L MA Modulator DMV934L RN Anti-human immunodeficiency virus type 1 activity of an oligocationic compound mediated via gp120 V3 interactions. J Virol. 1996 May;70(5):2825-31. DMV934L RU https://pubmed.ncbi.nlm.nih.gov/8627756 DMH5LFR DI DMH5LFR DMH5LFR DN ALXN6000 DMH5LFR MI TT0BE68 DMH5LFR MN Membrane glycoprotein OX2 (CD200) DMH5LFR MT DTT DMH5LFR RN American Society of Hematology, 52nd Annual Meeting and Exposition. P T. 2011 February; 36(2): 100-103. DMH5LFR RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3086088/ DM7ZQAT DI DM7ZQAT DM7ZQAT DN ALZ-801 DM7ZQAT MI TTE4KHA DM7ZQAT MN Amyloid beta A4 protein (APP) DM7ZQAT MT DTT DM7ZQAT MA Inhibitor DM7ZQAT RN Oral Clinical Candidate ALZ-801 in Alzheon's pipeline. 2012. DM7ZQAT RU http://www.alzheon.com/?page_id=280 DM9UMSJ DI DM9UMSJ DM9UMSJ DN AM001 DM9UMSJ MI TTOE7I0 DM9UMSJ MN Rap guanine nucleotide exchange factor 3 (RAPGEF3) DM9UMSJ MT DTT DM9UMSJ MA Inhibitor DM9UMSJ RN Identification of a pharmacological inhibitor of Epac1 that protects the heart against acute and chronic models of cardiac stress. Cardiovasc Res. 2019 Oct 1;115(12):1766-1777. DM9UMSJ RU https://pubmed.ncbi.nlm.nih.gov/30873562 DMGVQI8 DI DMGVQI8 DMGVQI8 DN AM-001 DMGVQI8 MI TTRLW2X DMGVQI8 MN Fibroblast growth factor receptor 1 (FGFR1) DMGVQI8 MT DTT DMGVQI8 MA Antagonist DMGVQI8 RN Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800029917) DMGVQI8 RU http://adisinsight.springer.com/drugs/800029917 DMBWNX5 DI DMBWNX5 DMBWNX5 DN AMA-76 DMBWNX5 MI TTMQO60 DMBWNX5 MN Rho-associated protein kinase (ROCK) DMBWNX5 MT DTT DMBWNX5 MA Modulator DMBWNX5 RN AMA0076, a novel, locally acting Rho kinase inhibitor, potently lowers intraocular pressure in New Zealand white rabbits with minimal hyperemia. Invest Ophthalmol Vis Sci. 2014 Feb 18;55(2):1006-16. DMBWNX5 RU https://pubmed.ncbi.nlm.nih.gov/24474276 DMEB3T9 DI DMEB3T9 DMEB3T9 DN Amdoxovir DMEB3T9 MI TT84ETX DMEB3T9 MN Human immunodeficiency virus Reverse transcriptase (HIV RT) DMEB3T9 MT DTT DMEB3T9 MA Modulator DMEB3T9 RN Amdoxovir versus placebo with enfuvirtide plus optimized background therapy for HIV-1-infected subjects failing current therapy (AACTG A5118). Antivir Ther. 2006;11(5):619-23. DMEB3T9 RU https://www.ncbi.nlm.nih.gov/pubmed/16964830 DMIVZ3M DI DMIVZ3M DMIVZ3M DN AME-133v DMIVZ3M MI TTUE541 DMIVZ3M MN Leukocyte surface antigen Leu-16 (CD20) DMIVZ3M MT DTT DMIVZ3M RN Results of a phase 1 study of AME-133v (LY2469298), an Fc-engineered humanized monoclonal anti-CD20 antibody, in FcgammaRIIIa-genotyped patients with previously treated follicular lymphoma. Clin Cancer Res. 2012 Mar 1;18(5):1395-403. DMIVZ3M RU https://pubmed.ncbi.nlm.nih.gov/22223529 DMUMCB9 DI DMUMCB9 DMUMCB9 DN Amelubant DMUMCB9 MI TTN53ZF DMUMCB9 MN Leukotriene B4 receptor 1 (LTB4R) DMUMCB9 MT DTT DMUMCB9 MA Antagonist DMUMCB9 RN Leukotriene receptor antagonists in children with cystic fibrosis lung disease : anti-inflammatory and clinical effects. Paediatr Drugs. 2005;7(6):353-63. DMUMCB9 RU https://pubmed.ncbi.nlm.nih.gov/16356023 DMGOFL3 DI DMGOFL3 DMGOFL3 DN AMG 151 DMGOFL3 MI TTDLNGZ DMGOFL3 MN Glucokinase (GCK) DMGOFL3 MT DTT DMGOFL3 MA Inhibitor DMGOFL3 RN This week in therapeutics Endocrine disease. SciBX 2(37); doi:10.1038/scibx.2009.1408. Sept. 24, 2009 DMGOFL3 RU http://www.nature.com/scibx/journal/v2/n37/pdf/scibx.2009.1408.pdf DMPQHOR DI DMPQHOR DMPQHOR DN AMG 208 DMPQHOR MI TTNDSF4 DMPQHOR MN Proto-oncogene c-Met (MET) DMPQHOR MT DTT DMPQHOR MA Modulator DMPQHOR RN A first-in-human study of AMG 208, an oral MET inhibitor, in adult patients with advanced solid tumors. Oncotarget. 2015 Jul 30;6(21):18693-706. DMPQHOR RU https://pubmed.ncbi.nlm.nih.gov/26155941 DM65PTO DI DM65PTO DM65PTO DN AMG 232 DM65PTO MI TT08GJW DM65PTO MN Ubiquitin-protein ligase E3 Mdm2 (MDM2) DM65PTO MT DTT DM65PTO MA Modulator DM65PTO RN Discovery of a small molecule MDM2 inhibitor (AMG 232) for treating cancer. J Med Chem. 2014 Aug 14;57(15):6332-41. DM65PTO RU https://pubmed.ncbi.nlm.nih.gov/24967612 DMO72IF DI DMO72IF DMO72IF DN AMG 301 DMO72IF MI TT5OREU DMO72IF MN PACAP type I receptor (PAC1R) DMO72IF MT DTT DMO72IF MA Inhibitor DMO72IF RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMO72IF RU http://phrma-docs.phrma.org/files/dmfile/MID_Neurological-Disorders-Drug-List_2018.pdf DMI3WFG DI DMI3WFG DMI3WFG DN AMG 334 DMI3WFG MI TTY6O0Q DMI3WFG MN Calcitonin gene-related peptide receptor (CGRPR) DMI3WFG MT DTT DMI3WFG MA Modulator DMI3WFG RN EHMTI-0315. AMG 334, the first potent and selective human monoclonal antibody antagonist against the CGRP receptor. J Headache Pain. 2014; 15(Suppl 1): G43. DMI3WFG RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4182181/ DMIOUEY DI DMIOUEY DMIOUEY DN AMG 337 DMIOUEY MI TTNDSF4 DMIOUEY MN Proto-oncogene c-Met (MET) DMIOUEY MT DTT DMIOUEY MA Modulator DMIOUEY RN J Clin Oncol 32:5s, 2014 (suppl; abstr 2508). DMIOUEY RU http://meetinglibrary.asco.org/content/127112-144 DM0DRAZ DI DM0DRAZ DM0DRAZ DN AMG 479 DM0DRAZ MI TTHRID2 DM0DRAZ MN Insulin-like growth factor I receptor (IGF1R) DM0DRAZ MT DTT DM0DRAZ MA Inhibitor DM0DRAZ RN Clinical pipeline report, company report or official report of Amgen (2009). DM0DRAZ RU http://www.amgen.com/science/pipe.jsp DME6QH1 DI DME6QH1 DME6QH1 DN AMG 557 DME6QH1 MI TTB9Z8R DME6QH1 MN B7-related protein 1 (B7RP1) DME6QH1 MT DTT DME6QH1 MA Modulator DME6QH1 RN Administration Of AMG 557, A Human Anti-B7RP-1 (ICOSL) Antibody, Leads To The Selective Inhibition Of Anti-KLH IgG Responses In Subjects With SLE: Results Of A Phase 1 Randomized, Double-Blind, Placebo-Controlled, Sequential, Rising, Multiple-Dose Study. San Diego, CA October 25-30, 2013 DME6QH1 RU http://www.blackwellpublishing.com/acrmeeting/abstract.asp?MeetingID=799&id=109110 DMY1XJH DI DMY1XJH DMY1XJH DN AMG 570 DMY1XJH MI TTB9Z8R DMY1XJH MN B7-related protein 1 (B7RP1) DMY1XJH MT DTT DMY1XJH MA Inhibitor DMY1XJH RN Development of an ICOSL and BAFF bispecific inhibitor AMG 570 for systemic lupus erythematosus treatment. Clin Exp Rheumatol. Nov-Dec 2019;37(6):906-914. DMY1XJH RU https://pubmed.ncbi.nlm.nih.gov/30789152 DMY1XJH DI DMY1XJH DMY1XJH DN AMG 570 DMY1XJH MI TTWMIDN DMY1XJH MN B-cell-activating factor (TNFSF13B) DMY1XJH MT DTT DMY1XJH MA Inhibitor DMY1XJH RN Development of an ICOSL and BAFF bispecific inhibitor AMG 570 for systemic lupus erythematosus treatment. Clin Exp Rheumatol. Nov-Dec 2019;37(6):906-914. DMY1XJH RU https://pubmed.ncbi.nlm.nih.gov/30789152 DMFXN2T DI DMFXN2T DMFXN2T DN AMG 745 DMFXN2T MI TTSWPH8 DMFXN2T MN Growth/differentiation factor 8 (GDF-8) DMFXN2T MT DTT DMFXN2T MA Antagonist DMFXN2T RN The role of myostatin in muscle wasting: an overview. J Cachexia Sarcopenia Muscle. 2011 September; 2(3): 143-151. DMFXN2T RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3177043/ DMWPGB8 DI DMWPGB8 DMWPGB8 DN Amg 747 DMWPGB8 MI TTHJTF7 DMWPGB8 MN Glycine transporter GlyT-1 (SLC6A9) DMWPGB8 MT DTT DMWPGB8 MA Modulator DMWPGB8 RN Glycine transporters as novel therapeutic targets in schizophrenia, alcohol dependence and pain. Nat Rev Drug Discov. 2013 Nov;12(11):866-85. DMWPGB8 RU https://pubmed.ncbi.nlm.nih.gov/24172334 DM973N4 DI DM973N4 DM973N4 DN AMG 853 DM973N4 MI TTNVEIR DM973N4 MN Prostaglandin D2 receptor (PTGDR) DM973N4 MT DTT DM973N4 MA Modulator DM973N4 RN Safety and efficacy of the prostaglandin D2 receptor antagonist AMG 853 in asthmatic patients.J Allergy Clin Immunol.2013 Feb;131(2):339-45. DM973N4 RU https://www.ncbi.nlm.nih.gov/pubmed/23174659 DM973N4 DI DM973N4 DM973N4 DN AMG 853 DM973N4 MI TTQDMX5 DM973N4 MN Prostaglandin D2 receptor 2 (PTGDR2) DM973N4 MT DTT DM973N4 MA Modulator DM973N4 RN Safety and efficacy of the prostaglandin D2 receptor antagonist AMG 853 in asthmatic patients.J Allergy Clin Immunol.2013 Feb;131(2):339-45. DM973N4 RU https://www.ncbi.nlm.nih.gov/pubmed/23174659 DM3H0IX DI DM3H0IX DM3H0IX DN AMG 890 DM3H0IX MI TTU9LGY DM3H0IX MN Apolipoprotein A messenger RNA (LPA mRNA) DM3H0IX MT DTT DM3H0IX MA Inhibitor DM3H0IX RN Clinical pipeline report, company report or official report of Amgen. DM3H0IX RU https://www.amgenpipeline.com/ DMODJTX DI DMODJTX DMODJTX DN AMG-181 DMODJTX MI TT4BT06 DMODJTX MN Integrin alpha-4 (ITGA4) DMODJTX MT DTT DMODJTX MA Inhibitor DMODJTX RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMODJTX RU http://phrma-docs.phrma.org/files/dmfile/medicines-in-development-drug-list-autoimmune-diseases.pdf DMODJTX DI DMODJTX DMODJTX DN AMG-181 DMODJTX MI TTLT9XQ DMODJTX MN Integrin beta-7 (ITGB7) DMODJTX MT DTT DMODJTX RN Pharmacology of AMG 181, a human anti-alpha4 beta7 antibody that specifically alters trafficking of gut-homing T cells. Br J Pharmacol. 2013 May;169(1):51-68. DMODJTX RU https://pubmed.ncbi.nlm.nih.gov/23425116 DM1T3KQ DI DM1T3KQ DM1T3KQ DN AMG-714 DM1T3KQ MI TTJFA35 DM1T3KQ MN Interleukin-15 (IL15) DM1T3KQ MT DTT DM1T3KQ RN Emerging drugs for rheumatoid arthritis. Expert Opin Emerg Drugs. 2008 Mar;13(1):175-96. DM1T3KQ RU https://pubmed.ncbi.nlm.nih.gov/18321156 DMJ4GPR DI DMJ4GPR DMJ4GPR DN AMP-579 DMJ4GPR MI TTK25J1 DMJ4GPR MN Adenosine A1 receptor (ADORA1) DMJ4GPR MT DTT DMJ4GPR MA Modulator DMJ4GPR RN Adenosine A1/A2a receptor agonist AMP-579 induces acute and delayed preconditioning against in vivo myocardial stunning. Am J Physiol Heart Circ Physiol. 2004 Dec;287(6):H2746-53. DMJ4GPR RU https://pubmed.ncbi.nlm.nih.gov/15271662 DMJ4GPR DI DMJ4GPR DMJ4GPR DN AMP-579 DMJ4GPR MI TTM2AOE DMJ4GPR MN Adenosine A2a receptor (ADORA2A) DMJ4GPR MT DTT DMJ4GPR MA Modulator DMJ4GPR RN Adenosine A1/A2a receptor agonist AMP-579 induces acute and delayed preconditioning against in vivo myocardial stunning. Am J Physiol Heart Circ Physiol. 2004 Dec;287(6):H2746-53. DMJ4GPR RU https://pubmed.ncbi.nlm.nih.gov/15271662 DMGE8FK DI DMGE8FK DMGE8FK DN AMR-001 DMGE8FK MI TTZAVYN DMGE8FK MN Hematopoietic progenitor cell antigen CD34 (CD34) DMGE8FK MT DTT DMGE8FK MA Modulator DMGE8FK RN National Cancer Institute Drug Dictionary (drug id 743421). DMGE8FK RU http://www.cancer.gov/publications/dictionaries/cancer-drug?cdrid=743421 DMOB01U DI DMOB01U DMOB01U DN Amsilarotene DMOB01U MI TTOD7B3 DMOB01U MN Retinoic acid receptor (RAR) DMOB01U MT DTT DMOB01U MA Antagonist DMOB01U RN Initial clinical trial of oral TAC-101, a novel retinoic acid receptor-alpha selective retinoid, in patients with advanced cancer. J Clin Oncol. 2002 Aug 15;20(16):3522-32. DMOB01U RU https://pubmed.ncbi.nlm.nih.gov/12177113 DMS0GA6 DI DMS0GA6 DMS0GA6 DN AMY-101 DMS0GA6 MI TTJGY7A DMS0GA6 MN Complement C3 (CO3) DMS0GA6 MT DTT DMS0GA6 MA Inhibitor DMS0GA6 RN The first case of COVID-19 treated with the complement C3 inhibitor AMY-101. Clin Immunol. 2020 Jun;215:108450. DMS0GA6 RU https://pubmed.ncbi.nlm.nih.gov/32360516 DMT3S10 DI DMT3S10 DMT3S10 DN AN0128 DMT3S10 MI TTF8CQI DMT3S10 MN Tumor necrosis factor (TNF) DMT3S10 MT DTT DMT3S10 MA Inhibitor DMT3S10 RN Inhibition of experimental periodontitis by a topical boron-based antimicrobial. J Dent Res. 2008 Feb;87(2):148-52. DMT3S10 RU https://pubmed.ncbi.nlm.nih.gov/18218841 DMJ7QP8 DI DMJ7QP8 DMJ7QP8 DN AN-019 DMJ7QP8 MI TTS7G69 DMJ7QP8 MN Fusion protein Bcr-Abl (Bcr-Abl) DMJ7QP8 MT DTT DMJ7QP8 MA Inhibitor DMJ7QP8 RN Design, synthesis and preclinical evaluation of NRC-AN-019. Int J Oncol. 2013 Jan;42(1):168-78. DMJ7QP8 RU https://pubmed.ncbi.nlm.nih.gov/23151973 DM3JNXS DI DM3JNXS DM3JNXS DN AN-1792 DM3JNXS MI TTE4KHA DM3JNXS MN Amyloid beta A4 protein (APP) DM3JNXS MT DTT DM3JNXS MA Inhibitor DM3JNXS RN Amyloid-beta peptide remnants in AN-1792-immunized Alzheimer's disease patients: a biochemical analysis. Am J Pathol. 2006 Sep;169(3):1048-63. DM3JNXS RU https://pubmed.ncbi.nlm.nih.gov/16936277 DMDK7CL DI DMDK7CL DMDK7CL DN AN-2898 DMDK7CL MI TTZ97H5 DMDK7CL MN Phosphodiesterase 4A (PDE4A) DMDK7CL MT DTT DMDK7CL MA Inhibitor DMDK7CL RN An assessment of the genetic toxicology of novel boron-containing therapeutic agents. Environ Mol Mutagen. 2013 Jun;54(5):338-46. DMDK7CL RU https://pubmed.ncbi.nlm.nih.gov/23625818 DMDK7CL DI DMDK7CL DMDK7CL DN AN-2898 DMDK7CL MI TTVIAT9 DMDK7CL MN Phosphodiesterase 4B (PDE4B) DMDK7CL MT DTT DMDK7CL MA Inhibitor DMDK7CL RN An assessment of the genetic toxicology of novel boron-containing therapeutic agents. Environ Mol Mutagen. 2013 Jun;54(5):338-46. DMDK7CL RU https://pubmed.ncbi.nlm.nih.gov/23625818 DMDK7CL DI DMDK7CL DMDK7CL DN AN-2898 DMDK7CL MI TTSKMI8 DMDK7CL MN Phosphodiesterase 4D (PDE4D) DMDK7CL MT DTT DMDK7CL MA Inhibitor DMDK7CL RN An assessment of the genetic toxicology of novel boron-containing therapeutic agents. Environ Mol Mutagen. 2013 Jun;54(5):338-46. DMDK7CL RU https://pubmed.ncbi.nlm.nih.gov/23625818 DMG7IEN DI DMG7IEN DMG7IEN DN Anatibant DMG7IEN MI TTGY8IW DMG7IEN MN B2 bradykinin receptor (BDKRB2) DMG7IEN MT DTT DMG7IEN MA Antagonist DMG7IEN RN Inhibition of bradykinin B2 receptors before, not after onset of experimental subarachnoid hemorrhage prevents brain edema formation and improves functional outcome. Crit Care Med. 2009 Jul;37(7):2228-34. DMG7IEN RU https://pubmed.ncbi.nlm.nih.gov/19487935 DMTG2O0 DI DMTG2O0 DMTG2O0 DN Anrukinzumab DMTG2O0 MI TT0GVCH DMTG2O0 MN Interleukin-13 (IL13) DMTG2O0 MT DTT DMTG2O0 MA Modulator DMTG2O0 RN Anrukinzumab, an anti-interleukin 13 monoclonal antibody, in active UC: efficacy and safety from a phase IIa randomised multicentre study.Gut.2015 Jun;64(6):894-900. DMTG2O0 RU https://www.ncbi.nlm.nih.gov/pubmed/25567115 DMHVZ27 DI DMHVZ27 DMHVZ27 DN Anti-CD137 DMHVZ27 MI TTPW9LJ DMHVZ27 MN Co-stimulatory molecule 4-1BB (CD137) DMHVZ27 MT DTT DMHVZ27 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1878). DMHVZ27 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1878 DMPRIHK DI DMPRIHK DMPRIHK DN Anti-CD3 and anti-Her2/neu bispecific antibody-armed activated T cells DMPRIHK MI TT6EO5L DMPRIHK MN Erbb2 tyrosine kinase receptor (HER2) DMPRIHK MT DTT DMPRIHK RN Use of anti-CD3 x anti-HER2/neu bispecific antibody for redirecting cytotoxicity of activated T cells toward HER2/neu+ tumors. J Hematother Stem Cell Res. 2001 Apr;10(2):247-60. DMPRIHK RU https://pubmed.ncbi.nlm.nih.gov/11359672 DMVQHBK DI DMVQHBK DMVQHBK DN Anti-GD2 CART DMVQHBK MI TT80ARU DMVQHBK MN Ganglioside GD2 (GD2) DMVQHBK MT DTT DMVQHBK MA CAR-T-Cell-Therapy DMVQHBK RN ClinicalTrials.gov (NCT02765243) Anti-GD2 4th Generation CART Cells Targeting Refractory and/or Recurrent Neuroblastoma DMVQHBK RU https://clinicaltrials.gov/ct2/show/NCT02765243 DMVRNAO DI DMVRNAO DMVRNAO DN Anti-IP10 DMVRNAO MI TTQOVYA DMVRNAO MN C-X-C motif chemokine 10 (CXCL10) DMVRNAO MT DTT DMVRNAO RN Anti-IP-10 antibody (BMS-936557) for ulcerative colitis: a phase II randomised study. Gut. 2014 Mar;63(3):442-50. DMVRNAO RU https://pubmed.ncbi.nlm.nih.gov/23461895 DMJO402 DI DMJO402 DMJO402 DN Anti-LAG3 DMJO402 MI TTNVXAW DMJO402 MN Lymphocyte activation gene 3 protein (LAG3) DMJO402 MT DTT DMJO402 MA Inhibitor DMJO402 RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMJO402 RU http://phrma-docs.phrma.org/files/dmfile/MID_Immuno-Oncology-2017_Drug-List1.pdf DMQ58YH DI DMQ58YH DMQ58YH DN Anti-LT alpha DMQ58YH MI TTP73TM DMQ58YH MN Lymphotoxin-alpha (LTA) DMQ58YH MT DTT DMQ58YH RN Clinical pipeline report, company report or official report of Genentech (2011). DMQ58YH RU http://www.gene.com/gene/index.jsp DMQFU1R DI DMQFU1R DMQFU1R DN Anti-M1 prime DMQFU1R MI TTA5LWY DMQFU1R MN M1-prime segment of membrane-expressed IgE (M1 IgE) DMQFU1R MT DTT DMQFU1R RN Clinical pipeline report, company report or official report of Genentech (2011). DMQFU1R RU http://www.gene.com/gene/index.jsp DMJPZDC DI DMJPZDC DMJPZDC DN Anti-PSCA mab DMJPZDC MI TT9T4AV DMJPZDC MN Prostate stem cell antigen (PSCA) DMJPZDC MT DTT DMJPZDC MA Modulator DMJPZDC RN Phase I rapid dose-escalation study of AGS-1C4D4, a human anti-PSCA (prostate stem cell antigen) monoclonal antibody, in patients with castration-resistant prostate cancer: a PCCTC trial. Cancer Chemother Pharmacol. 2012 Mar;69(3):763-71. DMJPZDC RU https://pubmed.ncbi.nlm.nih.gov/22020316 DMDKRS3 DI DMDKRS3 DMDKRS3 DN Antistasin DMDKRS3 MI TTCIHJA DMDKRS3 MN Coagulation factor Xa (F10) DMDKRS3 MT DTT DMDKRS3 MA Inhibitor DMDKRS3 RN Novel approaches to the treatment of thrombosis. Trends Pharmacol Sci. 2002 Jan;23(1):25-32. DMDKRS3 RU https://pubmed.ncbi.nlm.nih.gov/11804648 DMRGQVZ DI DMRGQVZ DMRGQVZ DN Antroquinonol DMRGQVZ MI TT6S2FE DMRGQVZ MN DNA [cytosine-5]-methyltransferase 1 (DNMT1) DMRGQVZ MT DTT DMRGQVZ MA Inhibitor DMRGQVZ RN Antroquinonol D, isolated from Antrodia camphorata, with DNA demethylation and anticancer potential. J Agric Food Chem. 2014 Jun 18;62(24):5625-35. DMRGQVZ RU https://pubmed.ncbi.nlm.nih.gov/24784321 DMMJOZD DI DMMJOZD DMMJOZD DN ANW-32821 DMMJOZD MI DEKP5HX DMMJOZD MN Cholesterol 24-hydroxylase (CYP46A1) DMMJOZD MT DME DMMJOZD MA Metabolism DMMJOZD RN Cholesterol-metabolizing cytochromes P450. Drug Metab Dispos. 2006 Apr;34(4):513-20. DMMJOZD RU https://pubmed.ncbi.nlm.nih.gov/16434543 DMMJOZD DI DMMJOZD DMMJOZD DN ANW-32821 DMMJOZD MI DE98XPV DMMJOZD MN Cholesterol desmolase (CYP11A1) DMMJOZD MT DME DMMJOZD MA Metabolism DMMJOZD RN Cholesterol-metabolizing cytochromes P450. Drug Metab Dispos. 2006 Apr;34(4):513-20. DMMJOZD RU https://pubmed.ncbi.nlm.nih.gov/16434543 DMMJOZD DI DMMJOZD DMMJOZD DN ANW-32821 DMMJOZD MI DELIXR8 DMMJOZD MN Cytochrome P450 125A1 (cyp125) DMMJOZD MT DME DMMJOZD MA Metabolism DMMJOZD RN Function, essentiality, and expression of cytochrome P450 enzymes and their cognate redox partners in Mycobacterium tuberculosis: are they drug targets? Appl Microbiol Biotechnol. 2019 May;103(9):3597-3614. DMMJOZD RU https://pubmed.ncbi.nlm.nih.gov/30810776 DMMJOZD DI DMMJOZD DMMJOZD DN ANW-32821 DMMJOZD MI DE6ZDK4 DMMJOZD MN Cytochrome P450 125A3 (cyp125) DMMJOZD MT DME DMMJOZD MA Metabolism DMMJOZD RN Cholesterol ester oxidation by mycobacterial cytochrome P450. J Biol Chem. 2014 Oct 31;289(44):30417-25. DMMJOZD RU https://pubmed.ncbi.nlm.nih.gov/25210044 DMMJOZD DI DMMJOZD DMMJOZD DN ANW-32821 DMMJOZD MI DEMQ20F DMMJOZD MN Cytochrome P450 142A1 (cyp142) DMMJOZD MT DME DMMJOZD MA Metabolism DMMJOZD RN Function, essentiality, and expression of cytochrome P450 enzymes and their cognate redox partners in Mycobacterium tuberculosis: are they drug targets? Appl Microbiol Biotechnol. 2019 May;103(9):3597-3614. DMMJOZD RU https://pubmed.ncbi.nlm.nih.gov/30810776 DMMJOZD DI DMMJOZD DMMJOZD DN ANW-32821 DMMJOZD MI DEPUK4S DMMJOZD MN Cytochrome P450 142A2 (cyp142) DMMJOZD MT DME DMMJOZD MA Metabolism DMMJOZD RN Cholesterol ester oxidation by mycobacterial cytochrome P450. J Biol Chem. 2014 Oct 31;289(44):30417-25. DMMJOZD RU https://pubmed.ncbi.nlm.nih.gov/25210044 DMMJOZD DI DMMJOZD DMMJOZD DN ANW-32821 DMMJOZD MI DEDZRQ1 DMMJOZD MN Cytochrome P450 7A1 (CYP7A1) DMMJOZD MT DME DMMJOZD MA Metabolism DMMJOZD RN Cholesterol-metabolizing cytochromes P450. Drug Metab Dispos. 2006 Apr;34(4):513-20. DMMJOZD RU https://pubmed.ncbi.nlm.nih.gov/16434543 DMMJOZD DI DMMJOZD DMMJOZD DN ANW-32821 DMMJOZD MI DEBS639 DMMJOZD MN Vitamin D(3) 25-hydroxylase (CYP27A1) DMMJOZD MT DME DMMJOZD MA Metabolism DMMJOZD RN Cholesterol-metabolizing cytochromes P450. Drug Metab Dispos. 2006 Apr;34(4):513-20. DMMJOZD RU https://pubmed.ncbi.nlm.nih.gov/16434543 DMYBQEF DI DMYBQEF DMYBQEF DN AP26113 DMYBQEF MI TTPMQSO DMYBQEF MN ALK tyrosine kinase receptor (ALK) DMYBQEF MT DTT DMYBQEF MA Modulator DMYBQEF RN Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41. DMYBQEF RU https://www.ncbi.nlm.nih.gov/pubmed/15950434 DM3ICYL DI DM3ICYL DM3ICYL DN AP-301-IH DM3ICYL MI TTF8CQI DM3ICYL MN Tumor necrosis factor (TNF) DM3ICYL MT DTT DM3ICYL MA Inhibitor DM3ICYL RN AP301, a synthetic peptide mimicking the lectin-like domain of TNF, enhances amiloride-sensitive Na(+) current in primary dog, pig and rat alveolar type II cells. Pulm Pharmacol Ther. 2013 Jun;26(3):356-63. DM3ICYL RU https://pubmed.ncbi.nlm.nih.gov/23313096 DMISQOZ DI DMISQOZ DMISQOZ DN AP-761 DMISQOZ MI TTQDMX5 DMISQOZ MN Prostaglandin D2 receptor 2 (PTGDR2) DMISQOZ MT DTT DMISQOZ MA Antagonist DMISQOZ RN Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800028464) DMISQOZ RU http://adisinsight.springer.com/drugs/800028464 DM1B8IT DI DM1B8IT DM1B8IT DN Apadoline DM1B8IT MI TTQW87Y DM1B8IT MN Opioid receptor kappa (OPRK1) DM1B8IT MT DTT DM1B8IT MA Agonist DM1B8IT RN Novel developments with selective, non-peptidic kappa-opioid receptor agonists. Expert Opin Investig Drugs. 1997 Oct;6(10):1351-68. DM1B8IT RU https://pubmed.ncbi.nlm.nih.gov/15989506 DMQMV9F DI DMQMV9F DMQMV9F DN Apaxifylline DMQMV9F MI TTK25J1 DMQMV9F MN Adenosine A1 receptor (ADORA1) DMQMV9F MT DTT DMQMV9F MA Antagonist DMQMV9F RN Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800004779) DMQMV9F RU http://adisinsight.springer.com/drugs/800004779 DM3VP19 DI DM3VP19 DM3VP19 DN APC-8015F DM3VP19 MI TTCT6F7 DM3VP19 MN Intercellular adhesion molecule ICAM-1 (ICAM1) DM3VP19 MT DTT DM3VP19 MA Modulator DM3VP19 RN National Cancer Institute Drug Dictionary (drug id 561410). DM3VP19 RU http://www.cancer.gov/publications/dictionaries/cancer-drug?cdrid=561410 DMNQ7DV DI DMNQ7DV DMNQ7DV DN APD-209 DMNQ7DV MI TT2CJVK DMNQ7DV MN Adrenergic receptor beta-2 (ADRB2) DMNQ7DV MT DTT DMNQ7DV MA Agonist DMNQ7DV RN Drugs in development for treatment of patients with cancer-related anorexia and cachexia syndrome. Retraction in: Drug Des Devel Ther. 2013; 7: 1385. DMNQ7DV RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3746778/ DM3XT5V DI DM3XT5V DM3XT5V DN APD371 DM3XT5V MI TTMSFAW DM3XT5V MN Cannabinoid receptor 2 (CB2) DM3XT5V MT DTT DM3XT5V MA Agonist DM3XT5V RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DM3XT5V RU http://phrma-docs.phrma.org/files/dmfile/MID_Neurological-Disorders-Drug-List_2018.pdf DM1VITS DI DM1VITS DM1VITS DN APD-403 DM1VITS MI TTEX248 DM1VITS MN Dopamine D2 receptor (D2R) DM1VITS MT DTT DM1VITS MA Antagonist DM1VITS RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 215). DM1VITS RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=215 DM9LZ0M DI DM9LZ0M DM9LZ0M DN APD-515 DM9LZ0M MI TTOXS3C DM9LZ0M MN Muscarinic acetylcholine receptor (CHRM) DM9LZ0M MT DTT DM9LZ0M MA Agonist DM9LZ0M RN Clinical pipeline report, company report or official report of Acacia Pharma. DM9LZ0M RU http://www.acaciapharma.com/pipeline/apd515 DM0FXMZ DI DM0FXMZ DM0FXMZ DN APG-101 DM0FXMZ MI TTF0RCZ DM0FXMZ MN Apoptosis mediating surface antigen FAS (FAS) DM0FXMZ MT DTT DM0FXMZ MA Inhibitor DM0FXMZ RN Pharmacokinetics, pharmacodynamics, safety and tolerability of APG101, a CD95-Fc fusion protein, in healthy volunteers and two glioma patients. Int Immunopharmacol. 2012 May;13(1):93-100. DM0FXMZ RU https://pubmed.ncbi.nlm.nih.gov/22446296 DMIFA0L DI DMIFA0L DMIFA0L DN APG-115 DMIFA0L MI TT7SBF5 DMIFA0L MN Cellular tumor antigen p53 (TP53) DMIFA0L MT DTT DMIFA0L MA Inhibitor DMIFA0L RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMIFA0L RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DMIFA0L DI DMIFA0L DMIFA0L DN APG-115 DMIFA0L MI TT08GJW DMIFA0L MN Ubiquitin-protein ligase E3 Mdm2 (MDM2) DMIFA0L MT DTT DMIFA0L MA Inhibitor DMIFA0L RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMIFA0L RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DM756GE DI DM756GE DM756GE DN APH-0812 DM756GE MI TTBH0VX DM756GE MN Histone deacetylase (HDAC) DM756GE MT DTT DM756GE MA Inhibitor DM756GE RN Targeting the protein kinase C family: are we there yet. Nat Rev Cancer. 2007 Jul;7(7):554-62. DM756GE RU https://pubmed.ncbi.nlm.nih.gov/17585335 DM756GE DI DM756GE DM756GE DN APH-0812 DM756GE MI TTYVX59 DM756GE MN Protein kinase C (PRKC) DM756GE MT DTT DM756GE MA Inhibitor DM756GE RN Targeting the protein kinase C family: are we there yet. Nat Rev Cancer. 2007 Jul;7(7):554-62. DM756GE RU https://pubmed.ncbi.nlm.nih.gov/17585335 DMHIS6Z DI DMHIS6Z DMHIS6Z DN Apilimod DMHIS6Z MI TT0S3MP DMHIS6Z MN HUMAN phosphatidylinositol 3-phosphate 5-kinase (PIKfyve) DMHIS6Z MT DTT DMHIS6Z MA Inhibitor DMHIS6Z RN A Large-scale Drug Repositioning Survey for SARS-CoV-2 Antivirals. April 17, 2020. DMHIS6Z RU https://www.biorxiv.org/content/10.1101/2020.04.16.044016v1 DM4N2O0 DI DM4N2O0 DM4N2O0 DN Apilimod dimesylate DM4N2O0 MI TTA4M1N DM4N2O0 MN Phosphatidylinositol-3-phosphate 5-kinase (PIP5K3) DM4N2O0 MT DTT DM4N2O0 MA Inhibitor DM4N2O0 RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DM4N2O0 RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DM7IGO9 DI DM7IGO9 DM7IGO9 DN Apimostinel DM7IGO9 MI TT9IK2Z DM7IGO9 MN N-methyl-D-aspartate receptor (NMDAR) DM7IGO9 MT DTT DM7IGO9 MA Partial agonist DM7IGO9 RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DM7IGO9 RU http://phrma-docs.phrma.org/files/dmfile/MID_Mental-Illness-2017-Drug-List_Final.pdf DMP0LST DI DMP0LST DMP0LST DN APL-101 DMP0LST MI TTNDSF4 DMP0LST MN Proto-oncogene c-Met (MET) DMP0LST MT DTT DMP0LST MA Inhibitor DMP0LST RN Clinical pipeline report, company report or official report of Apollomics. DMP0LST RU https://www.apollomicsinc.com/zh-hans/pipeline-drugs/apl-101/ DMGJ1X2 DI DMGJ1X2 DMGJ1X2 DN Aplindore fumarate DMGJ1X2 MI TTEX248 DMGJ1X2 MN Dopamine D2 receptor (D2R) DMGJ1X2 MT DTT DMGJ1X2 MA Agonist DMGJ1X2 RN The pipeline and future of drug development in schizophrenia. Mol Psychiatry. 2007 Oct;12(10):904-22. DMGJ1X2 RU https://pubmed.ncbi.nlm.nih.gov/17667958 DMGNFBC DI DMGNFBC DMGNFBC DN APN301 DMGNFBC MI TT80ARU DMGNFBC MN Ganglioside GD2 (GD2) DMGNFBC MT DTT DMGNFBC MA Inhibitor DMGNFBC RN Clinical pipeline report, company report or official report of Apeiron Biologics. DMGNFBC RU https://www.apeiron-biologics.com/childrens-oncology-group-and-apeiron-to-jointly-conduct-phase-ii-study-in-neuroblastoma-with-hu14-18-il2-apn301/ DM32YTJ DI DM32YTJ DM32YTJ DN APN-301 DM32YTJ MI TTF89GD DM32YTJ MN Interleukin-2 (IL2) DM32YTJ MT DTT DM32YTJ MA Modulator DM32YTJ RN Clinical pipeline report, company report or official report of APEIRON Biologics. DM32YTJ RU http://www.apeiron-biologics.com/index.php/projects/apn301-hu14-18-il2.html DMEXN7V DI DMEXN7V DMEXN7V DN APN401 DMEXN7V MI TTHRAIJ DMEXN7V MN CBLB messenger RNA (CBLB mRNA) DMEXN7V MT DTT DMEXN7V MA Inhibitor DMEXN7V RN Clinical pipeline report, company report or official report of Apeiron Biologics. DMEXN7V RU https://www.apeiron-biologics.com/science/#apn401 DMKVP7E DI DMKVP7E DMKVP7E DN Apolizumab DMKVP7E MI TTYA75N DMKVP7E MN MHC class II antigen DR (HLA-DR) DMKVP7E MT DTT DMKVP7E MA Modulator DMKVP7E RN A humanized HLA-DR antibody (hu1D10, apolizumab) in combination with granulocyte colony-stimulating factor (filgrastim) for the treatment of non-Hodgkin's lymphoma: a pilot study. DMKVP7E RU https://www.ncbi.nlm.nih.gov/pubmed/17071489 DM6B9HP DI DM6B9HP DM6B9HP DN Apomine DM6B9HP MI TTS4UGC DM6B9HP MN Farnesoid X-activated receptor (FXR) DM6B9HP MT DTT DM6B9HP MA Agonist DM6B9HP RN The nuclear receptors FXR and LXRalpha: potential targets for the development of drugs affecting lipid metabolism and neoplastic diseases. Curr Pharm Des. 2001 Mar;7(4):231-59. DM6B9HP RU https://pubmed.ncbi.nlm.nih.gov/11254888 DMNFADH DI DMNFADH DMNFADH DN APR-246 DMNFADH MI TT7SBF5 DMNFADH MN Cellular tumor antigen p53 (TP53) DMNFADH MT DTT DMNFADH MA Stimulator DMNFADH RN APR-246/PRIMA-1MET inhibits thioredoxin reductase 1 and converts the enzyme to a dedicated NADPH oxidase. Cell Death Dis. 2013 Oct 24;4:e881. DMNFADH RU https://pubmed.ncbi.nlm.nih.gov/24157875 DM8W4N9 DI DM8W4N9 DM8W4N9 DN Apratastat DM8W4N9 MI TTMX39J DM8W4N9 MN Matrix metalloproteinase-1 (MMP-1) DM8W4N9 MT DTT DM8W4N9 MA Inhibitor DM8W4N9 RN Acetylenic TACE inhibitors. Part 3: Thiomorpholine sulfonamide hydroxamates. Bioorg Med Chem Lett. 2006 Mar 15;16(6):1605-9. DM8W4N9 RU https://pubmed.ncbi.nlm.nih.gov/16426848 DM8W4N9 DI DM8W4N9 DM8W4N9 DN Apratastat DM8W4N9 MI TTHY57M DM8W4N9 MN Matrix metalloproteinase-13 (MMP-13) DM8W4N9 MT DTT DM8W4N9 MA Modulator DM8W4N9 RN Acetylenic TACE inhibitors. Part 3: Thiomorpholine sulfonamide hydroxamates. Bioorg Med Chem Lett. 2006 Mar 15;16(6):1605-9. DM8W4N9 RU https://pubmed.ncbi.nlm.nih.gov/16426848 DM8W4N9 DI DM8W4N9 DM8W4N9 DN Apratastat DM8W4N9 MI TT6AZXG DM8W4N9 MN TNF alpha converting enzyme (ADAM17) DM8W4N9 MT DTT DM8W4N9 MA Modulator DM8W4N9 RN Acetylenic TACE inhibitors. Part 3: Thiomorpholine sulfonamide hydroxamates. Bioorg Med Chem Lett. 2006 Mar 15;16(6):1605-9. DM8W4N9 RU https://pubmed.ncbi.nlm.nih.gov/16426848 DMEJICQ DI DMEJICQ DMEJICQ DN Aprocitentan DMEJICQ MI TTCV6O0 DMEJICQ MN Endothelin receptor (EDNR) DMEJICQ MT DTT DMEJICQ MA Antagonist DMEJICQ RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMEJICQ RU http://phrma-docs.phrma.org/files/dmfile/2018_Heart-Disease-and-Stroke_MID-Drug-List.pdf DMX2P5G DI DMX2P5G DMX2P5G DN APX005M DMX2P5G MI TTN6Y9A DMX2P5G MN CD40L receptor (CD40) DMX2P5G MT DTT DMX2P5G MA Agonist DMX2P5G RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMX2P5G RU http://phrma-docs.phrma.org/files/dmfile/MID_Immuno-Oncology-2017_Drug-List1.pdf DMU6NBO DI DMU6NBO DMU6NBO DN APX3330 DMU6NBO MI TTHGL48 DMU6NBO MN AP endonuclease 1 (APEX1) DMU6NBO MT DTT DMU6NBO MA Inhibitor DMU6NBO RN Exploiting the Ref-1-APE1 node in cancer signaling and other diseases: from bench to clinic. NPJ Precis Oncol. 2017;1:19. DMU6NBO RU https://pubmed.ncbi.nlm.nih.gov/28825044 DM1USXR DI DM1USXR DM1USXR DN AQ-13 DM1USXR MI TTKY2NS DM1USXR MN Duffy antigen chemokine receptor (ACKR1) DM1USXR MT DTT DM1USXR MA Modulator DM1USXR RN From control to eradication of malaria: the end of being stuck in second gear . Asian Pacific Journal of Tropical Medicine Volume 3, Issue 5, May 2010, Pages 412-420. DM1USXR RU http://www.sciencedirect.com/science/article/pii/S1995764510601010 DMD2RFO DI DMD2RFO DMD2RFO DN AQW-051 DMD2RFO MI TTLA931 DMD2RFO MN Neuronal acetylcholine receptor alpha-7 (CHRNA7) DMD2RFO MT DTT DMD2RFO MA Agonist DMD2RFO RN AQW051, a novel and selective nicotinic acetylcholine receptor alpha7 partial agonist, reduces l-Dopa-induced dyskinesias and extends the duration of l-Dopa effects in parkinsonian monkeys. Parkinsonism Relat Disord. 2014 Nov;20(11):1119-23. DMD2RFO RU https://pubmed.ncbi.nlm.nih.gov/25172125 DMCH3G5 DI DMCH3G5 DMCH3G5 DN AQX-1125 DMCH3G5 MI TTTP2Z1 DMCH3G5 MN SH2 domain inositol 5'-phosphatase 1 (INPP5D) DMCH3G5 MT DTT DMCH3G5 MA Agonist DMCH3G5 RN Characterization of AQX-1125, a small-molecule SHIP1 activator: Part 2. Efficacy studies in allergic and pulmonary inflammation models in vivo. Br J Pharmacol. 2013 Mar;168(6):1519-29. DMCH3G5 RU https://pubmed.ncbi.nlm.nih.gov/23121409 DM93CTQ DI DM93CTQ DM93CTQ DN AR08 DM93CTQ MI TTVIREA DM93CTQ MN Adrenergic receptor (ADR) DM93CTQ MT DTT DM93CTQ MA Modulator DM93CTQ RN Optimizing treatments for nicotine dependence by increasing cognitive performance during withdrawal. Expert Opin Drug Discov. 2014 June; 9(6): 579-594. DM93CTQ RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4287224/ DM5TC43 DI DM5TC43 DM5TC43 DN AR-12286 DM5TC43 MI TTMQO60 DM5TC43 MN Rho-associated protein kinase (ROCK) DM5TC43 MT DTT DM5TC43 MA Modulator DM5TC43 RN Ocular hypotensive effect of the Rho kinase inhibitor AR-12286 in patients with glaucoma and ocular hypertension. Am J Ophthalmol. 2011 Nov;152(5):834-41.e1. DM5TC43 RU https://pubmed.ncbi.nlm.nih.gov/21794845 DM8A71F DI DM8A71F DM8A71F DN AR-67 DM8A71F MI TTGTQHC DM8A71F MN DNA topoisomerase I (TOP1) DM8A71F MT DTT DM8A71F MA Inhibitor DM8A71F RN Protracted dosing of the lipophilic camptothecin analogue AR-67 in non-small cell lung cancer xenografts and humans. Cancer Chemother Pharmacol. 2014 Jul;74(1):45-54. DM8A71F RU https://pubmed.ncbi.nlm.nih.gov/24807458 DMJHA6Q DI DMJHA6Q DMJHA6Q DN Ar9281 DMJHA6Q MI TT7WVHI DMJHA6Q MN Soluble epoxide hydrolase (EPHX2) DMJHA6Q MT DTT DMJHA6Q MA Inhibitor DMJHA6Q RN Orally bioavailable potent soluble epoxide hydrolase inhibitors. J Med Chem. 2007 Aug 9;50(16):3825-40. DMJHA6Q RU https://pubmed.ncbi.nlm.nih.gov/17616115 DM7PCLY DI DM7PCLY DM7PCLY DN ARC1779 DM7PCLY MI TT3SZBT DM7PCLY MN von Willebrand factor (VWF) DM7PCLY MT DTT DM7PCLY MA Inhibitor DM7PCLY RN Short-Acting Anti-VWF (von Willebrand Factor) Aptamer Improves the Recovery, Survival, and Hemostatic Functions of Refrigerated Platelets. Arterioscler Thromb Vasc Biol. 2019 Oct;39(10):2028-2037. DM7PCLY RU https://pubmed.ncbi.nlm.nih.gov/31315441 DM9LNXS DI DM9LNXS DM9LNXS DN ARI-3037MO DM9LNXS MI TTRHEQ4 DM9LNXS MN Diacylglycerol O-acyltransferase 2 (DGAT2) DM9LNXS MT DTT DM9LNXS MA Inhibitor DM9LNXS RN 2011 Pipeline of Arisaph Pharmaceuticals. DM9LNXS RU http://www.arisaph.com/ DM9LNXS DI DM9LNXS DM9LNXS DN ARI-3037MO DM9LNXS MI TT8WFXV DM9LNXS MN Hydroxycarboxylic acid receptor 3 (HCAR3) DM9LNXS MT DTT DM9LNXS MA Agonist DM9LNXS RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DM9LNXS RU http://phrma-docs.phrma.org/files/dmfile/2018_Heart-Disease-and-Stroke_MID-Drug-List.pdf DM9LNXS DI DM9LNXS DM9LNXS DN ARI-3037MO DM9LNXS MI TTWNV8U DM9LNXS MN Nicotinic acid receptor (HCAR2) DM9LNXS MT DTT DM9LNXS MA Agonist DM9LNXS RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DM9LNXS RU http://phrma-docs.phrma.org/files/dmfile/2018_Heart-Disease-and-Stroke_MID-Drug-List.pdf DML3PJF DI DML3PJF DML3PJF DN ARN-810 DML3PJF MI TTZAYWL DML3PJF MN Estrogen receptor (ESR) DML3PJF MT DTT DML3PJF MA Modulator DML3PJF RN Identification of GDC-0810 (ARN-810), an Orally Bioavailable Selective Estrogen Receptor Degrader (SERD) that Demonstrates Robust Activity in Tamoxifen-Resistant Breast Cancer Xenografts. J Med Chem.2015 Jun 25;58(12):4888-904. DML3PJF RU https://pubmed.ncbi.nlm.nih.gov/25879485 DM2UP6Z DI DM2UP6Z DM2UP6Z DN ARO-AAT DM2UP6Z MI TT2L4TV DM2UP6Z MN SERPINA1 messenger RNA (SERPINA1 mRNA) DM2UP6Z MT DTT DM2UP6Z RN Clinical pipeline report, company report or official report of Arrowhead Pharmaceuticals. DM2UP6Z RU https://arrowheadpharma.com/pipeline/ DM5WK0J DI DM5WK0J DM5WK0J DN ARQ 092 DM5WK0J MI TTWTSCV DM5WK0J MN RAC-alpha serine/threonine-protein kinase (AKT1) DM5WK0J MT DTT DM5WK0J MA Inhibitor DM5WK0J RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DM5WK0J RU http://phrma-docs.phrma.org/sites/default/files/pdf/medicines-in-development-drug-list-rare-diseases.pdf DM5WK0J DI DM5WK0J DM5WK0J DN ARQ 092 DM5WK0J MI TTAZ05C DM5WK0J MN RAC-gamma serine/threonine-protein kinase (AKT3) DM5WK0J MT DTT DM5WK0J MA Modulator DM5WK0J RN Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41. DM5WK0J RU https://www.ncbi.nlm.nih.gov/pubmed/15950434 DMRG0A3 DI DMRG0A3 DMRG0A3 DN ARQ 531 DMRG0A3 MI TTGM6VW DMRG0A3 MN Tyrosine-protein kinase BTK (ATK) DMRG0A3 MT DTT DMRG0A3 MA Inhibitor DMRG0A3 RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMRG0A3 RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DMH5CAL DI DMH5CAL DMH5CAL DN ARQ 761 DMH5CAL MI TT8XK6L DMH5CAL MN Quinone reductase 1 (NQO1) DMH5CAL MT DTT DMH5CAL MA Inhibitor DMH5CAL RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMH5CAL RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DMYEIOH DI DMYEIOH DMYEIOH DN ARQ-154 DMYEIOH MI TTV5CGO DMYEIOH MN Phosphodiesterase 4 (PDE4) DMYEIOH MT DTT DMYEIOH MA Inhibitor DMYEIOH RN Clinical pipeline report, company report or official report of Arcutis Biotherapeutics. DMYEIOH RU https://arcutis.com/trial/arq-154/ DM0VGDC DI DM0VGDC DM0VGDC DN ARRY-382 DM0VGDC MI TT731LW DM0VGDC MN Colony stimulating factor-1 receptor (CSF-1R) DM0VGDC MT DTT DM0VGDC MA Modulator DM0VGDC RN Company report (Array) DM0VGDC RU http://www.arraybiopharma.com/product-pipeline/other-compounds/arry-382/ DM0VGDC DI DM0VGDC DM0VGDC DN ARRY-382 DM0VGDC MI TT7MRDV DM0VGDC MN Macrophage colony-stimulating factor 1 receptor (CSF1R) DM0VGDC MT DTT DM0VGDC MA Inhibitor DM0VGDC RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DM0VGDC RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DM17469 DI DM17469 DM17469 DN ARRY-502 DM17469 MI TTQDMX5 DM17469 MN Prostaglandin D2 receptor 2 (PTGDR2) DM17469 MT DTT DM17469 MA Modulator DM17469 RN Clinical pipeline report, company report or official report of Array BioPharma (Drug: ARRY-502). DM17469 RU http://www.arraybiopharma.com/product-pipeline/other-compounds/arry-502/ DMTOI7S DI DMTOI7S DMTOI7S DN ARRY-520 DMTOI7S MI TTTRP0H DMTOI7S MN Kinesin-like protein KIF11 (KIF11) DMTOI7S MT DTT DMTOI7S MA Inhibitor DMTOI7S RN Inhibition of KSP by ARRY-520 induces cell cycle block and cell death via the mitochondrial pathway in AML cells. Leukemia. 2009 Oct;23(10):1755-62. DMTOI7S RU https://pubmed.ncbi.nlm.nih.gov/19458629 DMJ48AB DI DMJ48AB DMJ48AB DN ARRY-797 DMJ48AB MI TTYT93M DMJ48AB MN MAP kinase p38 (MAPK12) DMJ48AB MT DTT DMJ48AB MA Inhibitor DMJ48AB RN Array BioPharmas ARRY-797 Meets Primary Endpoint in Clinical Proof of Concept Trial in Osteoarthritis Patients Whose Pain is Poorly Controlled by NSAIDs DMJ48AB RU http://investor.arraybiopharma.com/phoenix.zhtml?c=123810&p=irol-newsArticle&ID=1720505&highlight= DMJ48AB DI DMJ48AB DMJ48AB DN ARRY-797 DMJ48AB MI TTWELHI DMJ48AB MN Stress-activated protein kinase (p38) DMJ48AB MT DTT DMJ48AB MA Inhibitor DMJ48AB RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMJ48AB RU http://phrma-docs.phrma.org/sites/default/files/pdf/medicines-in-development-drug-list-rare-diseases.pdf DML27AE DI DML27AE DML27AE DN Arverapamil DML27AE MI TT5HONZ DML27AE MN Calcium channel unspecific (CaC) DML27AE MT DTT DML27AE MA Modulator DML27AE RN BJMP 2010;3(4):a342 DML27AE RU http://bjmp.org/files/2010-3-4/bjmp-2010-3-4-a342.pdf DML27AE DI DML27AE DML27AE DN Arverapamil DML27AE MI DTUGYRD DML27AE MN P-glycoprotein 1 (ABCB1) DML27AE MT DTP DML27AE MA Substrate DML27AE RN Characterization of the major metabolites of verapamil as substrates and inhibitors of P-glycoprotein. J Pharmacol Exp Ther. 2000 May;293(2):376-82. DML27AE RU http://jpet.aspetjournals.org/content/293/2/376.long DMMX1EJ DI DMMX1EJ DMMX1EJ DN AS-1402 DMMX1EJ MI TTBHFYQ DMMX1EJ MN Mucin-1 (MUC1) DMMX1EJ MT DTT DMMX1EJ RN Phase I dose escalation pharmacokinetic assessment of intravenous humanized anti-MUC1 antibody AS1402 in patients with advanced breast cancer. Breast Cancer Res. 2009;11(5):R73. DMMX1EJ RU https://pubmed.ncbi.nlm.nih.gov/19811637 DMTUMYX DI DMTUMYX DMTUMYX DN AS-902330 DMTUMYX MI TT6ICRA DMTUMYX MN Fibroblast growth factor-18 (FGF18) DMTUMYX MT DTT DMTUMYX MA Modulator DMTUMYX RN Intraarticular sprifermin (recombinant human fibroblast growth factor 18) in knee osteoarthritis: a randomized, double-blind, placebo-controlled trial. Arthritis Rheumatol. 2014 Jul;66(7):1820-31. DMTUMYX RU https://pubmed.ncbi.nlm.nih.gov/24740822 DMNVU28 DI DMNVU28 DMNVU28 DN ASB17061 DMNVU28 MI TT8VUE0 DMNVU28 MN Chymase (CYM) DMNVU28 MT DTT DMNVU28 MA Modulator DMNVU28 RN Immunology of atopic eczema: overcoming the Th1/Th2 paradigm. Allergy. 2013 Aug;68(8):974-82. DMNVU28 RU https://pubmed.ncbi.nlm.nih.gov/23889510 DMMBVCJ DI DMMBVCJ DMMBVCJ DN ASCJ-9 DMMBVCJ MI TTS64P2 DMMBVCJ MN Androgen receptor (AR) DMMBVCJ MT DTT DMMBVCJ MA Enhancer DMMBVCJ RN Anti-androgen receptor ASC-J9 versus anti-androgens MDV3100 (Enzalutamide) or Casodex (Bicalutamide) leads to opposite effects on prostate cancer metastasis via differential modulation of macrophage infiltration and STAT3-CCL2 signaling. Cell Death Dis. 2013 Aug 8;4:e764. DMMBVCJ RU https://pubmed.ncbi.nlm.nih.gov/23928703 DMDQS4W DI DMDQS4W DMDQS4W DN ASC-J9 DMDQS4W MI TTS64P2 DMDQS4W MN Androgen receptor (AR) DMDQS4W MT DTT DMDQS4W MA Inhibitor DMDQS4W RN New therapeutic approach to suppress castration-resistant prostate cancer using ASC-J9 via targeting androgen receptor in selective prostate cells. Am J Pathol. 2013 Feb;182(2):460-73. DMDQS4W RU https://pubmed.ncbi.nlm.nih.gov/23219429 DMZF68E DI DMZF68E DMZF68E DN Ascrolimus DMZF68E MI TTFH2RS DMZF68E MN FK506-binding protein (FKBP) DMZF68E MT DTT DMZF68E MA Modulator DMZF68E RN Mode of action of tacrolimus (FK506): molecular and cellular mechanisms. Ther Drug Monit. 1995 Dec;17(6):584-91. DMZF68E RU https://pubmed.ncbi.nlm.nih.gov/8588225 DM1CLKO DI DM1CLKO DM1CLKO DN ASKP-1240 DM1CLKO MI TTN6Y9A DM1CLKO MN CD40L receptor (CD40) DM1CLKO MT DTT DM1CLKO RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1874). DM1CLKO RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1874 DM35S2I DI DM35S2I DM35S2I DN ASM-024 DM35S2I MI TTJSZTB DM35S2I MN Nicotinic acetylcholine receptor (nAChR) DM35S2I MT DTT DM35S2I MA Agonist DM35S2I RN Effects of ASM-024, a modulator of acetylcholine receptor function, on airway responsiveness and allergen-induced responses in patients with mild asthma. Can Respir J. 2015 Jul-Aug;22(4):230-4. DM35S2I RU https://pubmed.ncbi.nlm.nih.gov/26252534 DMTHR4U DI DMTHR4U DMTHR4U DN ASM8 DMTHR4U MI TTU3Y87 DMTHR4U MN CCR3 messenger RNA (CCR3 mRNA) DMTHR4U MT DTT DMTHR4U RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 60). DMTHR4U RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=60 DM92X7N DI DM92X7N DM92X7N DN ASN002 DM92X7N MI TT2HUPM DM92X7N MN SYK messenger RNA (SYK mRNA) DM92X7N MT DTT DM92X7N MA Inhibitor DM92X7N RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DM92X7N RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DMWPGLS DI DMWPGLS DMWPGLS DN ASN100 DMWPGLS MI TT5FLYB DMWPGLS MN Staphylococcus Alpha-hemolysin (Stap-coc hly) DMWPGLS MT DTT DMWPGLS MA Modulator DMWPGLS RN Antibacterial antibodies gain traction. Nat Rev Drug Discov. 2015 Nov;14(11):737-8. DMWPGLS RU https://www.ncbi.nlm.nih.gov/pubmed/26514853 DMWPGLS DI DMWPGLS DMWPGLS DN ASN100 DMWPGLS MI TTKE96O DMWPGLS MN Staphylococcus Five leukocidin toxins (Stap-coc lukF) DMWPGLS MT DTT DMWPGLS MA Modulator DMWPGLS RN Antibacterial antibodies gain traction. Nat Rev Drug Discov. 2015 Nov;14(11):737-8. DMWPGLS RU https://www.ncbi.nlm.nih.gov/pubmed/26514853 DM6HJ3V DI DM6HJ3V DM6HJ3V DN ASP0819 DM6HJ3V MI TT7M9I6 DM6HJ3V MN Calcium-activated potassium channel KCa3.1 (KCNN4) DM6HJ3V MT DTT DM6HJ3V MA Activator DM6HJ3V RN Efficacy and Safety of ASP0819 in Patients with Fibromyalgia: Results of a Proof-of-Concept, Randomized, Double-Blind, Placebo-Controlled Trial. J Pain Res. 2020 Dec 10;13:3355-3369. DM6HJ3V RU https://pubmed.ncbi.nlm.nih.gov/33328761 DME8XD7 DI DME8XD7 DME8XD7 DN ASP-1707 DME8XD7 MI TT8R70G DME8XD7 MN Gonadotropin-releasing hormone receptor (GNRHR) DME8XD7 MT DTT DME8XD7 MA Antagonist DME8XD7 RN Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800032657) DME8XD7 RU http://adisinsight.springer.com/drugs/800032657 DMBADQV DI DMBADQV DMBADQV DN ASP-3291 DMBADQV MI TTEOSZT DMBADQV MN Melanocortin receptor (MCR) DMBADQV MT DTT DMBADQV MA Modulator DMBADQV RN Clinical pipeline report, company report or official report of Drais Pharmaceuticals. DMBADQV RU http://www.draispharma.com/press.php DM4KTN6 DI DM4KTN6 DM4KTN6 DN ASP-3652 DM4KTN6 MI TTMXGCW DM4KTN6 MN Adrenergic receptor beta-3 (ADRB3) DM4KTN6 MT DTT DM4KTN6 MA Agonist DM4KTN6 RN Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800029610) DM4KTN6 RU http://adisinsight.springer.com/drugs/800029610 DMZUAH2 DI DMZUAH2 DMZUAH2 DN ASP-4901 DMZUAH2 MI TTZOEBC DMZUAH2 MN Phosphodiesterase 9 (PDE9) DMZUAH2 MT DTT DMZUAH2 MA Inhibitor DMZUAH2 RN Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800033070) DMZUAH2 RU http://adisinsight.springer.com/drugs/800033070 DMTF24A DI DMTF24A DMTF24A DN ASP-7035 DMTF24A MI TTK8R02 DMTF24A MN Vasopressin V2 receptor (V2R) DMTF24A MT DTT DMTF24A MA Agonist DMTF24A RN Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800030285) DMTF24A RU http://adisinsight.springer.com/drugs/800030285 DMGDF2X DI DMGDF2X DMGDF2X DN ASP-7147 DMGDF2X MI TTC1MVT DMGDF2X MN Gastrin-releasing peptide receptor (GRPR) DMGDF2X MT DTT DMGDF2X MA Antagonist DMGDF2X RN Astellas and Drais Partner To Develop Third Astellas Compound through Tacurion DMGDF2X RU http://www.astellas.com/en/corporate/news/detail/astellas-and-drais-partner-to-.html DM3TN1A DI DM3TN1A DM3TN1A DN ASP7991 DM3TN1A MI TTBUYHA DM3TN1A MN Extracellular calcium-sensing receptor (CASR) DM3TN1A MT DTT DM3TN1A MA Agonist DM3TN1A RN Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800035616) DM3TN1A RU http://adisinsight.springer.com/drugs/800035616 DMR1MIV DI DMR1MIV DMR1MIV DN ASP8062 DMR1MIV MI TTDCVZW DMR1MIV MN Gamma-aminobutyric acid B receptor (GABBR) DMR1MIV MT DTT DMR1MIV MA Modulator DMR1MIV RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMR1MIV RU http://phrma-docs.phrma.org/files/dmfile/MID_Neurological-Disorders-Drug-List_2018.pdf DMYK1JU DI DMYK1JU DMYK1JU DN ASP8232 DMYK1JU MI TT7HC21 DMYK1JU MN Membrane copper amine oxidase (AOC3) DMYK1JU MT DTT DMYK1JU MA Inhibitor DMYK1JU RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMYK1JU RU http://phrma-docs.phrma.org/files/dmfile/mid-diabetes-drug-list.pdf DMHLXUY DI DMHLXUY DMHLXUY DN ASP8273 DMHLXUY MI TTGKNB4 DMHLXUY MN Epidermal growth factor receptor (EGFR) DMHLXUY MT DTT DMHLXUY MA Inhibitor DMHLXUY RN Phase I dose escalation study of ASP8273, a mutant-selective irreversible EGFR inhibitor, in subjects with EGFR mutation positive NSCLC, Journal of Clinical Oncology, Vol 33, No 15_suppl (May 20 Supplement), 2015: 8083. DMHLXUY RU http://meeting.ascopubs.org/cgi/content/abstract/33/15_suppl/8083 DMBZQS7 DI DMBZQS7 DMBZQS7 DN ASP-8477 DMBZQS7 MI TTVJ1D8 DMBZQS7 MN Vascular endothelial growth factor receptor (VEGFR) DMBZQS7 MT DTT DMBZQS7 MA Modulator DMBZQS7 RN ClinicalTrials.gov (NCT02065349) A Study Into Pain Relief Given by ASP8477 for Peripheral Neuropathic Pain (Either Post-herpetic Neuralgia or Painful Diabetic Peripheral Neuropathy) and Its Safety. U.S. National Institutes of Health. DMBZQS7 RU https://clinicaltrials.gov/ct2/show/NCT02065349 DM2MSGF DI DM2MSGF DM2MSGF DN ASP9831 DM2MSGF MI TTV5CGO DM2MSGF MN Phosphodiesterase 4 (PDE4) DM2MSGF MT DTT DM2MSGF MA Inhibitor DM2MSGF RN Lack of efficacy of an inhibitor of PDE4 in phase 1 and 2 trials of patients with nonalcoholic steatohepatitis. Clin Gastroenterol Hepatol. 2014 Oct;12(10):1724-30.e5. DM2MSGF RU https://pubmed.ncbi.nlm.nih.gov/24530600 DMMKW8L DI DMMKW8L DMMKW8L DN ASTX660 DMMKW8L MI TTK3WBU DMMKW8L MN XIAP messenger RNA (XIAP mRNA) DMMKW8L MT DTT DMMKW8L MA Inhibitor DMMKW8L RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMMKW8L RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DMARIQK DI DMARIQK DMARIQK DN AT-527 DMARIQK MI TTSUKYD DMARIQK MN Virus RNA-dependent RNA polymerase (Viru RdRP) DMARIQK MT DTT DMARIQK MA Inhibitor DMARIQK RN AT-527, a Double Prodrug of a Guanosine Nucleotide Analog, Is a Potent Inhibitor of SARS-CoV-2 In Vitro and a Promising Oral Antiviral for Treatment of COVID-19. Antimicrob Agents Chemother. 2021 Mar 18;65(4):e02479-20. DMARIQK RU https://pubmed.ncbi.nlm.nih.gov/33558299 DM35KDA DI DM35KDA DM35KDA DN Ataciguat DM35KDA MI TTJME02 DM35KDA MN Atrial natriuretic peptide receptor A (NPR1) DM35KDA MT DTT DM35KDA MA Activator DM35KDA RN Pharma & Vaccines. Product Development Pipeline. April 29 2009. DM35KDA RU http://en.sanofi-aventis.com/binaries/RD_Phase_III_EN_tcm28-24007.pdf DM6ABD9 DI DM6ABD9 DM6ABD9 DN ATHX-105 DM6ABD9 MI TTWJBZ5 DM6ABD9 MN 5-HT 2C receptor (HTR2C) DM6ABD9 MT DTT DM6ABD9 MA Agonist DM6ABD9 RN Pharmacological targeting of the serotonergic system for the treatment of obesity. J Physiol. 2009 January 1; 587(Pt 1): 49-60. DM6ABD9 RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2670022/ DMWP59B DI DMWP59B DMWP59B DN ATI-2042 DMWP59B MI TT5HONZ DMWP59B MN Calcium channel unspecific (CaC) DMWP59B MT DTT DMWP59B MA Agonist DMWP59B RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMWP59B RU http://phrma-docs.phrma.org/files/dmfile/2018_Heart-Disease-and-Stroke_MID-Drug-List.pdf DMWP59B DI DMWP59B DMWP59B DN ATI-2042 DMWP59B MI TTM7WCE DMWP59B MN Ion channel unspecific (IC) DMWP59B MT DTT DMWP59B MA Antagonist DMWP59B RN A randomized trial of budiodarone in paroxysmal atrial fibrillation. J Interv Card Electrophysiol. 2012 Jun;34(1):1-9. DMWP59B RU https://pubmed.ncbi.nlm.nih.gov/22205496 DMWP59B DI DMWP59B DMWP59B DN ATI-2042 DMWP59B MI TT1VOHK DMWP59B MN Potassium channel unspecific (KC) DMWP59B MT DTT DMWP59B MA Agonist DMWP59B RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMWP59B RU http://phrma-docs.phrma.org/files/dmfile/2018_Heart-Disease-and-Stroke_MID-Drug-List.pdf DMWP59B DI DMWP59B DMWP59B DN ATI-2042 DMWP59B MI TTRK8B9 DMWP59B MN Sodium channel unspecific (NaC) DMWP59B MT DTT DMWP59B MA Agonist DMWP59B RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMWP59B RU http://phrma-docs.phrma.org/files/dmfile/2018_Heart-Disease-and-Stroke_MID-Drug-List.pdf DMT5QYJ DI DMT5QYJ DMT5QYJ DN ATI-2173 DMT5QYJ MI TTT4SY6 DMT5QYJ MN Hepatitis B virus Polymerase (HBV P) DMT5QYJ MT DTT DMT5QYJ MA Inhibitor DMT5QYJ RN ATI-2173, a Novel Liver-Targeted Non-Chain-Terminating Nucleotide for Hepatitis B Virus Cure Regimens. Antimicrob Agents Chemother. 2020 Aug 20;64(9):e00836-20. DMT5QYJ RU https://pubmed.ncbi.nlm.nih.gov/32540975 DMTY6OF DI DMTY6OF DMTY6OF DN ATI-501 DMTY6OF MI TT6DM01 DMTY6OF MN Janus kinase 1 (JAK-1) DMTY6OF MT DTT DMTY6OF MA Inhibitor DMTY6OF RN Clinical pipeline report, company report or official report of Aclaris Therapeutics. DMTY6OF RU https://www.aclaristx.com/pipeline/ DMTY6OF DI DMTY6OF DMTY6OF DN ATI-501 DMTY6OF MI TTT7PJU DMTY6OF MN Janus kinase 3 (JAK-3) DMTY6OF MT DTT DMTY6OF MA Inhibitor DMTY6OF RN Clinical pipeline report, company report or official report of Aclaris Therapeutics. DMTY6OF RU https://www.aclaristx.com/pipeline/ DM8NODR DI DM8NODR DM8NODR DN ATI-502 DM8NODR MI TT6DM01 DM8NODR MN Janus kinase 1 (JAK-1) DM8NODR MT DTT DM8NODR MA Inhibitor DM8NODR RN ClinicalTrials.gov (NCT03759340) ATI-502 Topical Solution for the Treatment of Alopecia Areata (AA), Alopecia Universalis (AU) and Alopecia Totalis (AT). U.S. National Institutes of Health. DM8NODR RU https://clinicaltrials.gov/ct2/show/NCT03759340 DM8NODR DI DM8NODR DM8NODR DN ATI-502 DM8NODR MI TTT7PJU DM8NODR MN Janus kinase 3 (JAK-3) DM8NODR MT DTT DM8NODR MA Inhibitor DM8NODR RN ClinicalTrials.gov (NCT03759340) ATI-502 Topical Solution for the Treatment of Alopecia Areata (AA), Alopecia Universalis (AU) and Alopecia Totalis (AT). U.S. National Institutes of Health. DM8NODR RU https://clinicaltrials.gov/ct2/show/NCT03759340 DMK3VYU DI DMK3VYU DMK3VYU DN ATI-502 DMK3VYU MI TTJSQEF DMK3VYU MN Tyrosine-protein kinase (PTK) DMK3VYU MT DTT DMK3VYU MA Inhibitor DMK3VYU RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMK3VYU RU http://phrma-docs.phrma.org/files/dmfile/MID_Skin_Diseases_2018_9_FINAL.pdf DMYAQV2 DI DMYAQV2 DMYAQV2 DN ATL101 DMYAQV2 MI TT9G4N0 DMYAQV2 MN Glutamate carboxypeptidase II (GCPII) DMYAQV2 MT DTT DMYAQV2 MA Modulator DMYAQV2 RN Clinical pipeline report, company report or official report of Atlab pharma. DMYAQV2 RU http://www.atlab-pharma.com/pipeline_atl101.html DMD0I29 DI DMD0I29 DMD0I29 DN ATL-104 DMD0I29 MI TTDB5IS DMD0I29 MN Receptor unspecific (Rec) DMD0I29 MT DTT DMD0I29 MA Modulator DMD0I29 RN Treatment of oral mucositis after peripheral blood SCT with ATL-104 mouthwash: results from a randomized, double-blind, placebo-controlled trial. Bone Marrow Transplant. 2009 Apr;43(7):563-9. DMD0I29 RU https://pubmed.ncbi.nlm.nih.gov/18997832 DM3POT6 DI DM3POT6 DM3POT6 DN ATL1102 DM3POT6 MI TTJMF9P DM3POT6 MN ITGA4 messenger RNA (ITGA4 mRNA) DM3POT6 MT DTT DM3POT6 MA Modulator DM3POT6 RN CD49d antisense drug ATL1102 reduces disease activity in patients with relapsing-remitting MS.Neurology.2014 Nov 11;83(20):1780-8. DM3POT6 RU https://www.ncbi.nlm.nih.gov/pubmed/25239835 DM7I56B DI DM7I56B DM7I56B DN ATM AVI DM7I56B MI TTUE541 DM7I56B MN Leukocyte surface antigen Leu-16 (CD20) DM7I56B MT DTT DM7I56B MA Modulator DM7I56B RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2628). DM7I56B RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2628 DM4T9RS DI DM4T9RS DM4T9RS DN ATN-161 DM4T9RS MI TTH4QIS DM4T9RS MN Integrin alpha-5/beta-1 (ITGA5/B1) DM4T9RS MT DTT DM4T9RS MA Antagonist DM4T9RS RN A non-RGD-based integrin binding peptide (ATN-161) blocks breast cancer growth and metastasis in vivo. Mol Cancer Ther. 2006 Sep;5(9):2271-80. DM4T9RS RU https://pubmed.ncbi.nlm.nih.gov/16985061 DM4T9RS DI DM4T9RS DM4T9RS DN ATN-161 DM4T9RS MI TT69TQN DM4T9RS MN Integrin alpha-V/beta-3 (ITGAV/B3) DM4T9RS MT DTT DM4T9RS MA Antagonist DM4T9RS RN A non-RGD-based integrin binding peptide (ATN-161) blocks breast cancer growth and metastasis in vivo. Mol Cancer Ther. 2006 Sep;5(9):2271-80. DM4T9RS RU https://pubmed.ncbi.nlm.nih.gov/16985061 DMQJ5DV DI DMQJ5DV DMQJ5DV DN ATN-224 DMQJ5DV MI TT6RVLG DMQJ5DV MN Superoxide dismutase Cu-Zn (SOD Cu-Zn) DMQJ5DV MT DTT DMQJ5DV MA Inhibitor DMQJ5DV RN Copper binding by tetrathiomolybdate attenuates angiogenesis and tumor cell proliferation through the inhibition of superoxide dismutase 1. Clin Cancer Res. 2006 Aug 15;12(16):4974-82. DMQJ5DV RU https://pubmed.ncbi.nlm.nih.gov/16914587 DMUXO3Z DI DMUXO3Z DMUXO3Z DN AUS-131 DMUXO3Z MI DEUX61H DMUXO3Z MN Biphenyl dioxygenase (bphC) DMUXO3Z MT DME DMUXO3Z MA Metabolism DMUXO3Z RN Flavonoids biotransformation by bacterial non-heme dioxygenases, biphenyl and naphthalene dioxygenase. Appl Microbiol Biotechnol. 2011 Jul;91(2):219-28. DMUXO3Z RU https://pubmed.ncbi.nlm.nih.gov/21626021 DMZMSQJ DI DMZMSQJ DMZMSQJ DN AUS-131 DMZMSQJ MI TTOM3J0 DMZMSQJ MN Estrogen receptor beta (ESR2) DMZMSQJ MT DTT DMZMSQJ MA Agonist DMZMSQJ RN S-equol, a potent ligand for estrogen receptor beta, is the exclusive enantiomeric form of the soy isoflavone metabolite produced by human intestinal bacterial flora. Am J Clin Nutr. 2005 May;81(5):1072-9. DMZMSQJ RU https://pubmed.ncbi.nlm.nih.gov/15883431 DMN7VK1 DI DMN7VK1 DMN7VK1 DN AV-101 DMN7VK1 MI TT9IK2Z DMN7VK1 MN N-methyl-D-aspartate receptor (NMDAR) DMN7VK1 MT DTT DMN7VK1 MA Antagonist DMN7VK1 RN Clinical pipeline report, company report or official report of VistaGen Therapeutics, Inc. DMN7VK1 RU http://www.vistagen.com/?page_id=198 DMDL9WU DI DMDL9WU DMDL9WU DN AV-201 DMDL9WU MI TTN451K DMDL9WU MN Aromatic-L-amino-acid decarboxylase (DDC) DMDL9WU MT DTT DMDL9WU MA Modulator DMDL9WU RN UCSF report DMDL9WU RU http://pdcenter.neurology.ucsf.edu/research/learn-about-closed-studies/gene-therapy-aadc-phase-i DMASRP3 DI DMASRP3 DMASRP3 DN AVA-101 DMASRP3 MI TT9HKJA DMASRP3 MN Vascular endothelial growth factor (VEGF) DMASRP3 MT DTT DMASRP3 MA Modulator DMASRP3 RN Clinical pipeline report, company report or official report of Avalanche Biotechnologies. DMASRP3 RU http://www.avalanchebiotech.com/ DMORJD4 DI DMORJD4 DMORJD4 DN AVB-500 DMORJD4 MI TT69QD2 DMORJD4 MN AXL receptor tyrosine kinase ligand (GAS6) DMORJD4 MT DTT DMORJD4 MA Inhibitor DMORJD4 RN Clinical pipeline report, company report or official report of Aravive. DMORJD4 RU https://aravive.com/pipeline/ DMLAOHX DI DMLAOHX DMLAOHX DN Avdoralimab DMLAOHX MI TTQLO2H DMLAOHX MN HUMAN C5a receptor (C5aR) DMLAOHX MT DTT DMLAOHX MA Inhibitor DMLAOHX RN Blockade of the C5a-C5aR axis alleviates lung damage in hDPP4-transgenic mice infected with MERS-CoV. Emerg Microbes Infect. 2018 Apr 24;7(1):77. DMLAOHX RU https://pubmed.ncbi.nlm.nih.gov/29691378 DMESMHU DI DMESMHU DMESMHU DN AVE-0657 DMESMHU MI TTFZVPO DMESMHU MN Sodium/hydrogen exchanger 3 (SLC9A3) DMESMHU MT DTT DMESMHU MA Inhibitor DMESMHU RN Inhibition of central Na(+)/H(+) exchanger type 3 can alleviate sleep apnea in Sprague-Dawley rats. Chin Med J (Engl). 2014;127(1):48-53. DMESMHU RU https://pubmed.ncbi.nlm.nih.gov/24384423 DMA42BV DI DMA42BV DMA42BV DN AVE-2268 DMA42BV MI TTLWPVF DMA42BV MN Sodium/glucose cotransporter 2 (SGLT2) DMA42BV MT DTT DMA42BV MA Modulator DMA42BV RN Effects of AVE2268, a substituted glycopyranoside, on urinary glucose excretion and blood glucose in mice and rats. Arzneimittelforschung. 2008;58(11):574-80. DMA42BV RU https://pubmed.ncbi.nlm.nih.gov/19137908 DMQGI73 DI DMQGI73 DMQGI73 DN AVI-4557 DMQGI73 MI TTWP7HQ DMQGI73 MN CYP3A4 messenger RNA (CYP3A4 mRNA) DMQGI73 MT DTT DMQGI73 RN Phosphorodiamidate morpholino antisense oligomers inhibit expression of human cytochrome P450 3A4 and alter selected drug metabolism. Drug Metab Dispos. 2002 Jul;30(7):757-62. DMQGI73 RU https://pubmed.ncbi.nlm.nih.gov/12065433 DMUOYQR DI DMUOYQR DMUOYQR DN AVI-5126 DMUOYQR MI TTNQ5ZP DMUOYQR MN Myc messenger RNA (MYC mRNA) DMUOYQR MT DTT DMUOYQR RN Efficacy of a phosphorodiamidate morpholino oligomer antisense compound in the inhibition of corneal transplant rejection in a rat cornea transplant model. J Ocul Pharmacol Ther. 2012 Apr;28(2):194-201. DMUOYQR RU https://pubmed.ncbi.nlm.nih.gov/22149555 DMJFLBC DI DMJFLBC DMJFLBC DN AVN 101 DMJFLBC MI TTJS8PY DMJFLBC MN 5-HT 6 receptor (HTR6) DMJFLBC MT DTT DMJFLBC MA Modulator DMJFLBC RN Latrepirdine, a potential novel treatment for Alzheimer's disease and Huntington's chorea. Curr Opin Investig Drugs. 2010 January; 11(1): 80-91. DMJFLBC RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3346261/ DMK2LGM DI DMK2LGM DMK2LGM DN AVN 322 DMK2LGM MI TTJS8PY DMK2LGM MN 5-HT 6 receptor (HTR6) DMK2LGM MT DTT DMK2LGM MA Modulator DMK2LGM RN 5-HT6 receptors and Alzheimer's disease. Alzheimers Res Ther. 2013; 5(2): 15. DMK2LGM RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3706851/ DMOGFNI DI DMOGFNI DMOGFNI DN AVN-101 DMOGFNI MI TTO9X1H DMOGFNI MN 5-HT 7 receptor (HTR7) DMOGFNI MT DTT DMOGFNI MA Antagonist DMOGFNI RN AVN-101: A Multi-Target Drug Candidate for the Treatment of CNS Disorders. J Alzheimers Dis. 2016 May 25;53(2):583-620. DMOGFNI RU https://pubmed.ncbi.nlm.nih.gov/27232215 DMVADGZ DI DMVADGZ DMVADGZ DN AWD-12-281 DMVADGZ MI TTZ97H5 DMVADGZ MN Phosphodiesterase 4A (PDE4A) DMVADGZ MT DTT DMVADGZ MA Inhibitor DMVADGZ RN The phosphodiesterase 4 inhibitor AWD 12-281 is active in a new guinea-pig model of allergic skin inflammation predictive of human skin penetration and suppresses both Th1 and Th2 cytokines in mice. J Pharm Pharmacol. 2005 Dec;57(12):1609-17. DMVADGZ RU https://pubmed.ncbi.nlm.nih.gov/16354405 DMVADGZ DI DMVADGZ DMVADGZ DN AWD-12-281 DMVADGZ MI TTVIAT9 DMVADGZ MN Phosphodiesterase 4B (PDE4B) DMVADGZ MT DTT DMVADGZ MA Inhibitor DMVADGZ RN The phosphodiesterase 4 inhibitor AWD 12-281 is active in a new guinea-pig model of allergic skin inflammation predictive of human skin penetration and suppresses both Th1 and Th2 cytokines in mice. J Pharm Pharmacol. 2005 Dec;57(12):1609-17. DMVADGZ RU https://pubmed.ncbi.nlm.nih.gov/16354405 DMVADGZ DI DMVADGZ DMVADGZ DN AWD-12-281 DMVADGZ MI TTSKMI8 DMVADGZ MN Phosphodiesterase 4D (PDE4D) DMVADGZ MT DTT DMVADGZ MA Inhibitor DMVADGZ RN The phosphodiesterase 4 inhibitor AWD 12-281 is active in a new guinea-pig model of allergic skin inflammation predictive of human skin penetration and suppresses both Th1 and Th2 cytokines in mice. J Pharm Pharmacol. 2005 Dec;57(12):1609-17. DMVADGZ RU https://pubmed.ncbi.nlm.nih.gov/16354405 DMTAEMB DI DMTAEMB DMTAEMB DN AX-200 DMTAEMB MI TTC70AJ DMTAEMB MN Granulocyte colony-stimulating factor receptor (G-CSF-R) DMTAEMB MT DTT DMTAEMB MA Modulator DMTAEMB RN Granulocyte colony-stimulating factor in patients with acute ischemic stroke: results of the AX200 for Ischemic Stroke trial. Stroke. 2013 Oct;44(10):2681-7. DMTAEMB RU https://pubmed.ncbi.nlm.nih.gov/23963331 DMTQ1Y3 DI DMTQ1Y3 DMTQ1Y3 DN AXL-1717 DMTQ1Y3 MI TTHRID2 DMTQ1Y3 MN Insulin-like growth factor I receptor (IGF1R) DMTQ1Y3 MT DTT DMTQ1Y3 MA Inhibitor DMTQ1Y3 RN Clinical Phase I study with an Insulin-like Growth Factor-1 receptor inhibitor: experiences in patients with squamous non-small cell lung carcinoma. Acta Oncol. 2011 Apr;50(3):441-7. DMTQ1Y3 RU https://pubmed.ncbi.nlm.nih.gov/20698809 DM4CJNE DI DM4CJNE DM4CJNE DN AYX-1 DM4CJNE MI TTUQREN DM4CJNE MN Early growth response protein 1 (EGR-1) DM4CJNE MT DTT DM4CJNE MA Inhibitor DM4CJNE RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DM4CJNE RU http://phrma-docs.phrma.org/files/dmfile/MID_Neurological-Disorders-Drug-List_2018.pdf DMHFUJT DI DMHFUJT DMHFUJT DN AZ-01, PEGylated interferon-beta DMHFUJT MI TT4TZ8J DMHFUJT MN Interferon-beta (IFNB1) DMHFUJT MT DTT DMHFUJT MA Modulator DMHFUJT RN PEGylated interferon beta-1a in the treatment of multiple sclerosis - an update. Biologics. 2013; 7: 131-138. DMHFUJT RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3686537/ DM9LKYP DI DM9LKYP DM9LKYP DN AZ-40140 DM9LKYP MI TTMXGCW DM9LKYP MN Adrenergic receptor beta-3 (ADRB3) DM9LKYP MT DTT DM9LKYP MA Agonist DM9LKYP RN Emerging drugs for obesity: linking novel biological mechanisms to pharmaceutical pipelines. Expert Opin Emerg Drugs. 2005 Aug;10(3):643-60. DM9LKYP RU https://pubmed.ncbi.nlm.nih.gov/16083333 DMM0N1F DI DMM0N1F DMM0N1F DN AZD-0865 DMM0N1F MI TTLOKXP DMM0N1F MN Gastric H(+)/K(+) ATPase (Proton pump) DMM0N1F MT DTT DMM0N1F MA Modulator DMM0N1F RN Mechanism of action of AZD0865, a K+-competitive inhibitor of gastric H+,K+-ATPase. Biochem Pharmacol. 2007 Jan 15;73(2):198-205. DMM0N1F RU https://pubmed.ncbi.nlm.nih.gov/17081503 DM7B1AR DI DM7B1AR DM7B1AR DN AZD-1446 DM7B1AR MI TTL1ATN DM7B1AR MN Neuronal acetylcholine receptor alpha-4/beta-2 (CHRNA4/B2) DM7B1AR MT DTT DM7B1AR MA Modulator DM7B1AR RN A randomized, double-blind, placebo-controlled crossover study of 4 2* nicotinic acetylcholine receptor agonist AZD1446 (TC-6683) in adults with attention-deficit/hyperactivity disorder.Psychopharmacology (Berl). 2014 Mar;231(6):1251-65. DM7B1AR RU https://www.ncbi.nlm.nih.gov/pubmed/23640072 DMLK59M DI DMLK59M DMLK59M DN AZD1480 DMLK59M MI TTRMX3V DMLK59M MN Janus kinase 2 (JAK-2) DMLK59M MT DTT DMLK59M MA Modulator DMLK59M RN The JAK2 inhibitor AZD1480 potently blocks Stat3 signaling and oncogenesis in solid tumors. Cancer Cell. 2009 Dec 8;16(6):487-97. DMLK59M RU https://pubmed.ncbi.nlm.nih.gov/19962667 DMUE90I DI DMUE90I DMUE90I DN AZD1656 DMUE90I MI TTDLNGZ DMUE90I MN Glucokinase (GCK) DMUE90I MT DTT DMUE90I MA Activator DMUE90I RN Clinical pipeline report, company report or official report of AstraZeneca (2009). DMUE90I RU http://www.astrazeneca.com/_mshost3690701/content/resources/media/investors/AZN-Q2-2009/AZN-Q2-2009-Pipeline.pdf DMX5SG7 DI DMX5SG7 DMX5SG7 DN AZD1772//RDX5791 DMX5SG7 MI TTFZVPO DMX5SG7 MN Sodium/hydrogen exchanger 3 (SLC9A3) DMX5SG7 MT DTT DMX5SG7 MA Modulator DMX5SG7 RN RDX5791, a First-in-Class Minimally Systemic NHE3 Inhibitor in Clinical Development for CIC and IBS-C, Increases Intestinal Sodium Leading to Enhanced Intestinal Fluid Volume and Transit. Gastroenterology. 2011;140(suppl 1):S99. DMX5SG7 RU http://www.gastrojournal.org/article/S0016-5085(11)60405-8/pdf DMMCL9F DI DMMCL9F DMMCL9F DN AZD1981 DMMCL9F MI TTQDMX5 DMMCL9F MN Prostaglandin D2 receptor 2 (PTGDR2) DMMCL9F MT DTT DMMCL9F MA Antagonist DMMCL9F RN Clinical pipeline report, company report or official report of AstraZeneca (2009). DMMCL9F RU http://www.astrazeneca.com/_mshost3690701/content/resources/media/investors/AZN-Q2-2009/AZN-Q2-2009-Pipeline.pdf DMOEARH DI DMOEARH DMOEARH DN Azd2014 DMOEARH MI DES5XRU DMOEARH MN Cytochrome P450 2C8 (CYP2C8) DMOEARH MT DME DMOEARH MA Metabolism DMOEARH RN First-in-human pharmacokinetic and pharmacodynamic study of the dual m-TORC 1/2 inhibitor AZD2014. Clin Cancer Res. 2015 Aug 1;21(15):3412-9. DMOEARH RU https://www.ncbi.nlm.nih.gov/pubmed/?term=25805799 DMOEARH DI DMOEARH DMOEARH DN Azd2014 DMOEARH MI DE4LYSA DMOEARH MN Cytochrome P450 3A4 (CYP3A4) DMOEARH MT DME DMOEARH MA Metabolism DMOEARH RN First-in-human pharmacokinetic and pharmacodynamic study of the dual m-TORC 1/2 inhibitor AZD2014. Clin Cancer Res. 2015 Aug 1;21(15):3412-9. DMOEARH RU https://www.ncbi.nlm.nih.gov/pubmed/?term=25805799 DMOEARH DI DMOEARH DMOEARH DN Azd2014 DMOEARH MI DEIBDNY DMOEARH MN Cytochrome P450 3A5 (CYP3A5) DMOEARH MT DME DMOEARH MA Metabolism DMOEARH RN First-in-human pharmacokinetic and pharmacodynamic study of the dual m-TORC 1/2 inhibitor AZD2014. Clin Cancer Res. 2015 Aug 1;21(15):3412-9. DMOEARH RU https://www.ncbi.nlm.nih.gov/pubmed/?term=25805799 DMOEARH DI DMOEARH DMOEARH DN Azd2014 DMOEARH MI TTX4GLS DMOEARH MN Mammalian target of rapamycin complex 1 (mTORC1) DMOEARH MT DTT DMOEARH MA Inhibitor DMOEARH RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMOEARH RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DMOEARH DI DMOEARH DMOEARH DN Azd2014 DMOEARH MI TTCJG29 DMOEARH MN Serine/threonine-protein kinase mTOR (mTOR) DMOEARH MT DTT DMOEARH MA Inhibitor DMOEARH RN Dramatic suppression of colorectal cancer cell growth by the dual mTORC1 and mTORC2 inhibitor AZD-2014. Biochem Biophys Res Commun. 2014 Jan 10;443(2):406-12. DMOEARH RU https://pubmed.ncbi.nlm.nih.gov/24309100 DMOEARH DI DMOEARH DMOEARH DN Azd2014 DMOEARH MI TTWDKCL DMOEARH MN Target of rapamycin complex 2 MAPKAP1 (MTORC2) DMOEARH MT DTT DMOEARH MA Inhibitor DMOEARH RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMOEARH RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DMGQSVX DI DMGQSVX DMGQSVX DN AZD-2115 DMGQSVX MI TT2CJVK DMGQSVX MN Adrenergic receptor beta-2 (ADRB2) DMGQSVX MT DTT DMGQSVX MA Agonist DMGQSVX RN Evaluation of WO-2012085582 and WO-2012085583 two identified MABAs: backups to AZD-2115. Expert Opin Ther Pat. 2012 Nov;22(11):1377-83. DMGQSVX RU https://pubmed.ncbi.nlm.nih.gov/22917191 DMGQSVX DI DMGQSVX DMGQSVX DN AZD-2115 DMGQSVX MI TTOXS3C DMGQSVX MN Muscarinic acetylcholine receptor (CHRM) DMGQSVX MT DTT DMGQSVX MA Agonist DMGQSVX RN Evaluation of WO-2012085582 and WO-2012085583 two identified MABAs: backups to AZD-2115. Expert Opin Ther Pat. 2012 Nov;22(11):1377-83. DMGQSVX RU https://pubmed.ncbi.nlm.nih.gov/22917191 DM8FZOG DI DM8FZOG DM8FZOG DN AZD-2327 DM8FZOG MI TT27RFC DM8FZOG MN Opioid receptor delta (OPRD1) DM8FZOG MT DTT DM8FZOG MA Agonist DM8FZOG RN Preclinical pharmacology of AZD2327: a highly selective agonist of the delta-opioid receptor. J Pharmacol Exp Ther. 2011 Jul;338(1):195-204. DM8FZOG RU https://pubmed.ncbi.nlm.nih.gov/21444630 DMF34UY DI DMF34UY DMF34UY DN AZD-2423 DMF34UY MI TTFZYTO DMF34UY MN C-C chemokine receptor type 2 (CCR2) DMF34UY MT DTT DMF34UY MA Antagonist DMF34UY RN CA patent application no. 841416, Method of selecting therapeutic indications. DMF34UY RU http://www.google.com/patents/CA2841416A1?cl=en DMZLGQV DI DMZLGQV DMZLGQV DN AZD2624 DMZLGQV MI TTBPGLU DMZLGQV MN Neuromedin-K receptor (TACR3) DMZLGQV MT DTT DMZLGQV MA Modulator DMZLGQV RN The selective neurokinin 3 antagonist AZD2624 does not improve symptoms or cognition in schizophrenia: a proof-of-principle study.J Clin Psychopharmacol.2014 Apr;34(2):199-204. DMZLGQV RU https://www.ncbi.nlm.nih.gov/pubmed/24525659 DMYUNXP DI DMYUNXP DMYUNXP DN AZD2811 DMYUNXP MI TTCY4SB DMYUNXP MN Aurora kinase (AURK) DMYUNXP MT DTT DMYUNXP MA Inhibitor DMYUNXP RN Aurora kinase inhibitor nanoparticles target tumors with favorable therapeutic index in vivo. Sci Transl Med. 2016 Feb 10;8(325):325ra17. DMYUNXP RU https://pubmed.ncbi.nlm.nih.gov/26865565 DM6AI9N DI DM6AI9N DM6AI9N DN AZD-2927 DM6AI9N MI TTM7WCE DM6AI9N MN Ion channel unspecific (IC) DM6AI9N MT DTT DM6AI9N MA Modulator DM6AI9N RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7704). DM6AI9N RU http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=7704 DME8Z5M DI DME8Z5M DME8Z5M DN AZD-3199 DME8Z5M MI TT2CJVK DME8Z5M MN Adrenergic receptor beta-2 (ADRB2) DME8Z5M MT DTT DME8Z5M MA Agonist DME8Z5M RN Clinical pharmacokinetics of AZD3199, an inhaled ultra-long-acting beta2-adrenoreceptor agonist (uLABA). Drug Des Devel Ther. 2015; 9: 753-762. DME8Z5M RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4330041/ DMANC59 DI DMANC59 DMANC59 DN AZD-3241 DMANC59 MI TTVCZPI DMANC59 MN Myeloperoxidase (MPO) DMANC59 MT DTT DMANC59 MA Inhibitor DMANC59 RN Effect of the myeloperoxidase inhibitor AZD3241 on microglia: a PET study in Parkinson's disease. Brain. 2015 Sep;138(Pt 9):2687-700. DMANC59 RU https://pubmed.ncbi.nlm.nih.gov/26137956 DML9M5S DI DML9M5S DML9M5S DN AZD-4017 DML9M5S MI TTN7BL9 DML9M5S MN Corticosteroid 11-beta-dehydrogenase 1 (HSD11B1) DML9M5S MT DTT DML9M5S MA Inhibitor DML9M5S RN New Therapeutic Strategies for Type 2 Diabetes: Small Molecule Approaches. 2012. Chapter 5. Page(131). DML9M5S RU https://books.google.com.hk/books?id=0rmlVGhlJ0IC&pg=PA131&lpg=PA131&dq=RG-7234++New+Therapeutic+Strategies+for+Type+2+Diabetes&source=bl&ots=toqK7w4uiI&sig=sx5iyfQWH2bTCSZmT5aUQiKfPuM&hl=zh-CN&sa=X&ved=0CB0Q6AEwAGoVChMIsZ_k6dDGyAIViLeOCh0oUQpr#v=onepage&q=RG-7234%20%20New%20Therapeutic%20Strategies%20for%20Type%202%20Diabetes&f=false DM8SVIY DI DM8SVIY DM8SVIY DN AZD4635 DM8SVIY MI TTM2AOE DM8SVIY MN Adenosine A2a receptor (ADORA2A) DM8SVIY MT DTT DM8SVIY MA Antagonist DM8SVIY RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DM8SVIY RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DMFVL5J DI DMFVL5J DMFVL5J DN AZD-4877 DMFVL5J MI TTTRP0H DMFVL5J MN Kinesin-like protein KIF11 (KIF11) DMFVL5J MT DTT DMFVL5J MA Inhibitor DMFVL5J RN Kinesins and cancer. Nat Rev Cancer. 2012 Jul 24;12(8):527-39. DMFVL5J RU https://pubmed.ncbi.nlm.nih.gov/22825217 DM3JSFK DI DM3JSFK DM3JSFK DN AZD-5069 DM3JSFK MI TT30C9G DM3JSFK MN C-X-C chemokine receptor type 2 (CXCR2) DM3JSFK MT DTT DM3JSFK MA Inhibitor DM3JSFK RN Pharmacological characterization of AZD5069, a slowly reversible CXC chemokine receptor 2 antagonist. J Pharmacol Exp Ther. 2015 May;353(2):340-50. DM3JSFK RU https://pubmed.ncbi.nlm.nih.gov/25736418 DMOZ04X DI DMOZ04X DMOZ04X DN AZD-5213 DMOZ04X MI TT9JNIC DMOZ04X MN Histamine H3 receptor (H3R) DMOZ04X MT DTT DMOZ04X MA Antagonist DMOZ04X RN SAR110894, a potent histamine H receptor antagonist, displays procognitive effects in rodents. Pharmacol Biochem Behav. 2012 Aug;102(2):203-14. DMOZ04X RU https://pubmed.ncbi.nlm.nih.gov/22542742 DMJ8V3K DI DMJ8V3K DMJ8V3K DN AZD5312 DMJ8V3K MI TTS64P2 DMJ8V3K MN Androgen receptor (AR) DMJ8V3K MT DTT DMJ8V3K MA Modulator DMJ8V3K RN Company report (Astrazeneca) DMJ8V3K RU https://www.astrazeneca.com/our-company/media-centre/press-releases/2014/astrazeneca-isis-pharmaceuticals-oligonucleotide-oncology-cardiovascular-metabolic-diseases-13112014.html DM0PFNC DI DM0PFNC DM0PFNC DN AZD6738 DM0PFNC MI TT8ZYBQ DM0PFNC MN Serine/threonine-protein kinase ATR (FRP1) DM0PFNC MT DTT DM0PFNC MA Inhibitor DM0PFNC RN National Cancer Institute Drug Dictionary (drug id 754022). DM0PFNC RU http://www.cancer.gov/publications/dictionaries/cancer-drug?cdrid=754022 DMIBXK0 DI DMIBXK0 DMIBXK0 DN AZD-7009 DMIBXK0 MI TT1VOHK DMIBXK0 MN Potassium channel unspecific (KC) DMIBXK0 MT DTT DMIBXK0 MA Modulator DMIBXK0 RN Rapid slowing of the atrial fibrillatory rate after administration of AZD7009 predicts conversion of atrial fibrillation. J Electrocardiol. 2014 May-Jun;47(3):316-23. DMIBXK0 RU https://pubmed.ncbi.nlm.nih.gov/24508473 DMC48SP DI DMC48SP DMC48SP DN AZD-7268 DMC48SP MI TTN4QDT DMC48SP MN Opioid receptor (OPR) DMC48SP MT DTT DMC48SP MA Modulator DMC48SP RN EP patent application no. 2774991, Drug delivery system for use in the treatment or diagnosis of neurological disorders. DMC48SP RU http://www.google.com/patents/EP2774991A1?cl=en DMXF26Y DI DMXF26Y DMXF26Y DN AZD7325 DMXF26Y MI TTAN6JD DMXF26Y MN Glutamate receptor AMPA (GRIA) DMXF26Y MT DTT DMXF26Y MA Agonist DMXF26Y RN Clinical pipeline report, company report or official report of AstraZeneca (2009). DMXF26Y RU http://www.astrazeneca.com/_mshost3690701/content/resources/media/investors/AZN-Q2-2009/AZN-Q2-2009-Pipeline.pdf DMEW3K9 DI DMEW3K9 DMEW3K9 DN AZD7624 DMEW3K9 MI TTWELHI DMEW3K9 MN Stress-activated protein kinase (p38) DMEW3K9 MT DTT DMEW3K9 MA Inhibitor DMEW3K9 RN Investigational p38 inhibitors for the treatment of chronic obstructive pulmonary disease. Expert Opin Investig Drugs. 2015 Mar;24(3):383-92. DMEW3K9 RU https://pubmed.ncbi.nlm.nih.gov/25599809 DMLXFM6 DI DMLXFM6 DMLXFM6 DN AZD-8683 DMLXFM6 MI TTOXS3C DMLXFM6 MN Muscarinic acetylcholine receptor (CHRM) DMLXFM6 MT DTT DMLXFM6 MA Antagonist DMLXFM6 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 17). DMLXFM6 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=17 DM0M7QW DI DM0M7QW DM0M7QW DN AZD-8848 DM0M7QW MI TTRJ1K4 DM0M7QW MN Toll-like receptor 7 (TLR7) DM0M7QW MT DTT DM0M7QW MA Agonist DM0M7QW RN Repeated intranasal TLR7 stimulation reduces allergen responsiveness in allergic rhinitis. Respir Res. 2012 Jun 22;13:53. DM0M7QW RU https://pubmed.ncbi.nlm.nih.gov/22726593 DMFLCW4 DI DMFLCW4 DMFLCW4 DN AZD8931 DMFLCW4 MI TT6EO5L DMFLCW4 MN Erbb2 tyrosine kinase receptor (HER2) DMFLCW4 MT DTT DMFLCW4 MA Inhibitor DMFLCW4 RN Clinical pipeline report, company report or official report of AstraZeneca (2009). DMFLCW4 RU http://www.astrazeneca.com/_mshost3690701/content/resources/media/investors/AZN-Q2-2009/AZN-Q2-2009-Pipeline.pdf DMJGYPK DI DMJGYPK DMJGYPK DN AZD9056 DMJGYPK MI TT473XN DMJGYPK MN P2X purinoceptor 7 (P2RX7) DMJGYPK MT DTT DMJGYPK MA Antagonist DMJGYPK RN Clinical pipeline report, company report or official report of AstraZeneca (2009). DMJGYPK RU http://www.astrazeneca.com/_mshost3690701/content/resources/media/investors/AZN-Q2-2009/AZN-Q2-2009-Pipeline.pdf DMVKPEZ DI DMVKPEZ DMVKPEZ DN AZD-9164 DMVKPEZ MI TTOXS3C DMVKPEZ MN Muscarinic acetylcholine receptor (CHRM) DMVKPEZ MT DTT DMVKPEZ MA Antagonist DMVKPEZ RN The discovery of AZD9164, a novel muscarinic M3 antagonist. Bioorg Med Chem Lett. 2011 Dec 15;21(24):7440-6. DMVKPEZ RU https://pubmed.ncbi.nlm.nih.gov/22047691 DMB87M3 DI DMB87M3 DMB87M3 DN AZD9668 DMB87M3 MI TTPLTSQ DMB87M3 MN Neutrophil elastase (NE) DMB87M3 MT DTT DMB87M3 MA Inhibitor DMB87M3 RN Clinical pipeline report, company report or official report of AstraZeneca (2009). DMB87M3 RU http://www.astrazeneca.com/_mshost3690701/content/resources/media/investors/AZN-Q2-2009/AZN-Q2-2009-Pipeline.pdf DMQOTHP DI DMQOTHP DMQOTHP DN AZD9833 DMQOTHP MI TTZAYWL DMQOTHP MN Estrogen receptor (ESR) DMQOTHP MT DTT DMQOTHP MA Degrader DMQOTHP RN Discovery of AZD9833, a Potent and Orally Bioavailable Selective Estrogen Receptor Degrader and Antagonist. J Med Chem. 2020 Dec 10;63(23):14530-14559. DMQOTHP RU https://pubmed.ncbi.nlm.nih.gov/32910656 DME0JMV DI DME0JMV DME0JMV DN AZX-100 DME0JMV MI TT5IP87 DME0JMV MN Heat shock protein 20 (HSP20) DME0JMV MT DTT DME0JMV MA Modulator DME0JMV RN Internalization and intracellular trafficking of a PTD-conjugated anti-fibrotic peptide, AZX100, in human dermal keloid fibroblasts. J Pharm Sci. 2010 Jul;99(7):3100-21. DME0JMV RU https://pubmed.ncbi.nlm.nih.gov/20140957 DMOMDA4 DI DMOMDA4 DMOMDA4 DN B-701 DMOMDA4 MI TTST7KB DMOMDA4 MN Fibroblast growth factor receptor 3 (FGFR3) DMOMDA4 MT DTT DMOMDA4 MA Antagonist DMOMDA4 RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMOMDA4 RU http://phrma-docs.phrma.org/files/dmfile/MID_Immuno-Oncology-2017_Drug-List1.pdf DM7586F DI DM7586F DM7586F DN Bafetinib DM7586F MI TTS7G69 DM7586F MN Fusion protein Bcr-Abl (Bcr-Abl) DM7586F MT DTT DM7586F MA Modulator DM7586F RN Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41. DM7586F RU https://www.ncbi.nlm.nih.gov/pubmed/15950434 DM7586F DI DM7586F DM7586F DN Bafetinib DM7586F MI TT1RWNJ DM7586F MN Tyrosine-protein kinase Lyn (JTK8) DM7586F MT DTT DM7586F MA Modulator DM7586F RN Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41. DM7586F RU https://www.ncbi.nlm.nih.gov/pubmed/15950434 DM4C7E6 DI DM4C7E6 DM4C7E6 DN BAICALEIN DM4C7E6 MI TT2J34L DM4C7E6 MN Arachidonate 5-lipoxygenase (5-LOX) DM4C7E6 MT DTT DM4C7E6 MA Inhibitor DM4C7E6 RN Indazolinones, a new series of redox-active 5-lipoxygenase inhibitors with built-in selectivity and oral activity. J Med Chem. 1991 Mar;34(3):1028-36. DM4C7E6 RU https://pubmed.ncbi.nlm.nih.gov/1848292 DM4C7E6 DI DM4C7E6 DM4C7E6 DN BAICALEIN DM4C7E6 MI TTV9A7R DM4C7E6 MN Lactoylglutathione lyase (GLO1) DM4C7E6 MT DTT DM4C7E6 MA Inhibitor DM4C7E6 RN Structure-activity relationship of human GLO I inhibitory natural flavonoids and their growth inhibitory effects. Bioorg Med Chem. 2008 Apr 1;16(7):3969-75. DM4C7E6 RU https://pubmed.ncbi.nlm.nih.gov/18258440 DM4C7E6 DI DM4C7E6 DM4C7E6 DN BAICALEIN DM4C7E6 MI TT2IYXF DM4C7E6 MN L-selectin (SELL) DM4C7E6 MT DTT DM4C7E6 MA Inhibitor DM4C7E6 RN Rational design of novel, potent small molecule pan-selectin antagonists. J Med Chem. 2007 Mar 22;50(6):1101-15. DM4C7E6 RU https://pubmed.ncbi.nlm.nih.gov/17302397 DM4C7E6 DI DM4C7E6 DM4C7E6 DN BAICALEIN DM4C7E6 MI TTNGKET DM4C7E6 MN Prolyl endopeptidase (PREP) DM4C7E6 MT DTT DM4C7E6 MA Inhibitor DM4C7E6 RN Baicalin, a prodrug able to reach the CNS, is a prolyl oligopeptidase inhibitor. Bioorg Med Chem. 2008 Aug 1;16(15):7516-24. DM4C7E6 RU https://pubmed.ncbi.nlm.nih.gov/18650094 DM4C7E6 DI DM4C7E6 DM4C7E6 DN BAICALEIN DM4C7E6 MI TTE5VG0 DM4C7E6 MN P-selectin (SELP) DM4C7E6 MT DTT DM4C7E6 MA Inhibitor DM4C7E6 RN Rational design of novel, potent small molecule pan-selectin antagonists. J Med Chem. 2007 Mar 22;50(6):1101-15. DM4C7E6 RU https://pubmed.ncbi.nlm.nih.gov/17302397 DM4C7E6 DI DM4C7E6 DM4C7E6 DN BAICALEIN DM4C7E6 MI TTF8CQI DM4C7E6 MN Tumor necrosis factor (TNF) DM4C7E6 MT DTT DM4C7E6 MA Inhibitor DM4C7E6 RN Discovery of the inhibitors of tumor necrosis factor alpha with structure-based virtual screening. Bioorg Med Chem Lett. 2010 Nov 1;20(21):6195-8. DM4C7E6 RU https://pubmed.ncbi.nlm.nih.gov/20850306 DM4C7E6 DI DM4C7E6 DM4C7E6 DN BAICALEIN DM4C7E6 MI TT7RJY8 DM4C7E6 MN Xanthine dehydrogenase/oxidase (XDH) DM4C7E6 MT DTT DM4C7E6 MA Inhibitor DM4C7E6 RN Inhibition of cow's milk xanthine oxidase by flavonoids. J Nat Prod. 1988 Mar-Apr;51(2):345-8. DM4C7E6 RU https://pubmed.ncbi.nlm.nih.gov/3379415 DM3WCL4 DI DM3WCL4 DM3WCL4 DN Baltaleucel-T DM3WCL4 MI TTXQYT6 DM3WCL4 MN T-cells (T-cells) DM3WCL4 MT DTT DM3WCL4 MA Immunomodulator DM3WCL4 RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DM3WCL4 RU http://phrma-docs.phrma.org/files/dmfile/MID_Immuno-Oncology-2017_Drug-List1.pdf DMSZOXQ DI DMSZOXQ DMSZOXQ DN Baminercept DMSZOXQ MI TTFO0PM DMSZOXQ MN Lymphotoxin beta receptor (LTBR) DMSZOXQ MT DTT DMSZOXQ MA Antagonist DMSZOXQ RN ClinicalTrials.gov (NCT01552681) Baminercept in Sj ren's Syndrome. U.S. National Institutes of Health. DMSZOXQ RU https://clinicaltrials.gov/ct2/show/NCT01552681 DM0TZEP DI DM0TZEP DM0TZEP DN Bamosiran DM0TZEP MI TTG8ZWP DM0TZEP MN ADRB2 messenger RNA (ADRB2 mRNA) DM0TZEP MT DTT DM0TZEP MA Inhibitor DM0TZEP RN Clinical pipeline report, company report or official report of Sylentis. DM0TZEP RU https://www.sylentis.com/index.php/en/pipeline/bamosiran DMW03YD DI DMW03YD DMW03YD DN BAN2401 DMW03YD MI TTE4KHA DMW03YD MN Amyloid beta A4 protein (APP) DMW03YD MT DTT DMW03YD MA Modulator DMW03YD RN The murine version of BAN2401 (mAb158) selectively reduces amyloid-beta protofibrils in brain and cerebrospinal fluid of tg-ArcSwe mice. J Alzheimers Dis. 2015;43(2):575-88. DMW03YD RU https://pubmed.ncbi.nlm.nih.gov/25096615 DMWI0X3 DI DMWI0X3 DMWI0X3 DN Barusiban DMWI0X3 MI TTSCIUP DMWI0X3 MN Oxytocin receptor (OTR) DMWI0X3 MT DTT DMWI0X3 MA Antagonist DMWI0X3 RN The effect of barusiban, a selective oxytocin antagonist, in threatened preterm labor at late gestational age: a randomized, double-blind, placebo-controlled trial. Am J Obstet Gynecol. 2009 Jun;200(6):627.e1-10. DMWI0X3 RU https://pubmed.ncbi.nlm.nih.gov/19306963 DMQ8J0U DI DMQ8J0U DMQ8J0U DN Basmisanil DMQ8J0U MI TTNZPQ1 DMQ8J0U MN GABA(A) receptor alpha-5 (GABRA5) DMQ8J0U MT DTT DMQ8J0U MA Modulator DMQ8J0U RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMQ8J0U RU http://phrma-docs.phrma.org/files/dmfile/MID_Mental-Illness-2017-Drug-List_Final.pdf DM6CVZ5 DI DM6CVZ5 DM6CVZ5 DN Bavisant DM6CVZ5 MI TT9JNIC DM6CVZ5 MN Histamine H3 receptor (H3R) DM6CVZ5 MT DTT DM6CVZ5 MA Antagonist DM6CVZ5 RN Randomized clinical study of a histamine H3 receptor antagonist for the treatment of adults with attention-deficit hyperactivity disorder. CNS Drugs. 2012 May 1;26(5):421-34. DM6CVZ5 RU https://pubmed.ncbi.nlm.nih.gov/22519922 DM4JGNH DI DM4JGNH DM4JGNH DN BAY 1067197 DM4JGNH MI TTK25J1 DM4JGNH MN Adenosine A1 receptor (ADORA1) DM4JGNH MT DTT DM4JGNH MA Modulator DM4JGNH RN Separation of on-target efficacy from adverse effects through rational design of a bitopic adenosine receptor agonist. Current Issue vol. 111 no. 12 Celine Valant, 4614-4619. DM4JGNH RU http://www.pnas.org/content/111/12/4614 DMHKTGX DI DMHKTGX DMHKTGX DN BAY 1142524 DMHKTGX MI TT8VUE0 DMHKTGX MN Chymase (CYM) DMHKTGX MT DTT DMHKTGX MA Inhibitor DMHKTGX RN Pharmacokinetics, Safety, and Tolerability of the Novel Chymase Inhibitor BAY 1142524 in Healthy Male Volunteers. Clin Pharmacol Drug Dev. 2019 May;8(4):467-479. DMHKTGX RU https://pubmed.ncbi.nlm.nih.gov/29878583 DM8SNEM DI DM8SNEM DM8SNEM DN BAY 11-42524 DM8SNEM MI TT8VUE0 DM8SNEM MN Chymase (CYM) DM8SNEM MT DTT DM8SNEM MA Inhibitor DM8SNEM RN ClinicalTrials.gov (NCT02452515) A Single-blind Pilot Study to Investigate Safety and Tolerability of the Chymase Inhibitor BAY1142524 in Clinically Stable Patients With Left-ventricular Dysfunction. DM8SNEM RU https://clinicaltrials.gov/ct2/show/NCT02452515 DM450XS DI DM450XS DM450XS DN BAY 2253651 DM450XS MI TTGR91N DM450XS MN TWIK-related acid-sensitive potassium channel 1 (TASK1) DM450XS MT DTT DM450XS MA Inhibitor DM450XS RN Antibodies and venom peptides: new modalities for ion channels. Nat Rev Drug Discov. 2019 May;18(5):339-357. DM450XS RU https://pubmed.ncbi.nlm.nih.gov/30728472 DMSUB64 DI DMSUB64 DMSUB64 DN BAY 57-1293 DMSUB64 MI TTKCVJR DMSUB64 MN Herpes simplex virus Helicase-primase (HSV UL8) DMSUB64 MT DTT DMSUB64 MA Inhibitor DMSUB64 RN Helicase primase: targeting the Achilles heel of herpes simplex viruses. Antivir Chem Chemother. 2004 May;15(3):135-40. DMSUB64 RU https://pubmed.ncbi.nlm.nih.gov/15266895 DMA75FG DI DMA75FG DMA75FG DN BAY 794980 DMA75FG MI TT1290U DMA75FG MN Coagulation factor VIII (F8) DMA75FG MT DTT DMA75FG MA Modulator DMA75FG RN Efficacy and safety of prophylaxis with once-weekly BAY 79-4980 compared with thrice-weekly rFVIII-FS in haemophilia A patients. A randomised, active-controlled, double-blind study. Thromb Haemost. 2012 Nov;108(5):913-22. DMA75FG RU https://pubmed.ncbi.nlm.nih.gov/23014711 DMCPUKG DI DMCPUKG DMCPUKG DN BAY 85-8501 DMCPUKG MI TTPLTSQ DMCPUKG MN Neutrophil elastase (NE) DMCPUKG MT DTT DMCPUKG MA Modulator DMCPUKG RN Freezing the Bioactive Conformation to Boost Potency: The Identification of BAY 5-8501, a Selective and Potent Inhibitor of Human Neutrophil Elastase for Pulmonary Diseases. ChemMedChem. 2015 Jul;10(7):1163-73. DMCPUKG RU https://pubmed.ncbi.nlm.nih.gov/26083237 DMRZLU4 DI DMRZLU4 DMRZLU4 DN BAY 86-5044 DMRZLU4 MI TTKPW01 DMRZLU4 MN Androgen receptor messenger RNA (AR mRNA) DMRZLU4 MT DTT DMRZLU4 MA Inhibitor DMRZLU4 RN Synthesis and biological activity of a novel, highly potent progesterone receptor antagonist. J Med Chem. 2000 Dec 28;43(26):5010-6. DMRZLU4 RU https://pubmed.ncbi.nlm.nih.gov/11150172 DMRZLU4 DI DMRZLU4 DMRZLU4 DN BAY 86-5044 DMRZLU4 MI TTYRL6O DMRZLU4 MN Glucocorticoid receptor (NR3C1) DMRZLU4 MT DTT DMRZLU4 MA Inhibitor DMRZLU4 RN Synthesis and biological activity of a novel, highly potent progesterone receptor antagonist. J Med Chem. 2000 Dec 28;43(26):5010-6. DMRZLU4 RU https://pubmed.ncbi.nlm.nih.gov/11150172 DMRZLU4 DI DMRZLU4 DMRZLU4 DN BAY 86-5044 DMRZLU4 MI TTHL6YX DMRZLU4 MN Progesterone (PG) DMRZLU4 MT DTT DMRZLU4 MA Antagonist DMRZLU4 RN Randomized phase II study of lonaprisan as second-line therapy for progesterone receptor-positive breast cancer. Ann Oncol. 2013 Oct;24(10):2543-8. DMRZLU4 RU https://pubmed.ncbi.nlm.nih.gov/23788750 DMRZLU4 DI DMRZLU4 DMRZLU4 DN BAY 86-5044 DMRZLU4 MI TTUV8G9 DMRZLU4 MN Progesterone receptor (PGR) DMRZLU4 MT DTT DMRZLU4 MA Inhibitor DMRZLU4 RN Synthesis and biological activity of a novel, highly potent progesterone receptor antagonist. J Med Chem. 2000 Dec 28;43(26):5010-6. DMRZLU4 RU https://pubmed.ncbi.nlm.nih.gov/11150172 DMCSGJ2 DI DMCSGJ2 DMCSGJ2 DN BAY1163877 DMCSGJ2 MI TT0LF7H DMCSGJ2 MN Fibroblast growth factor receptor (FGFR) DMCSGJ2 MT DTT DMCSGJ2 MA Antagonist DMCSGJ2 RN Preclinical profile of BAY 1163877 - a selective pan-FGFR inhibitor in phase 1 clinical trial. Cancer Research. 10/2014; 74(19 Supplement):1739-1739. DMCSGJ2 RU http://cancerres.aacrjournals.org/content/74/19_Supplement/1739 DM83IYE DI DM83IYE DM83IYE DN BAY1193397 DM83IYE MI TT2NUT5 DM83IYE MN Adrenergic receptor alpha-2C (ADRA2C) DM83IYE MT DTT DM83IYE MA Antagonist DM83IYE RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DM83IYE RU http://phrma-docs.phrma.org/files/dmfile/2018_Heart-Disease-and-Stroke_MID-Drug-List.pdf DMYSQMW DI DMYSQMW DMYSQMW DN BAY-1902607 DMYSQMW MI TT2THBD DMYSQMW MN P2X purinoceptor 3 (P2RX3) DMYSQMW MT DTT DMYSQMW MA Inhibitor DMYSQMW RN Antibodies and venom peptides: new modalities for ion channels. Nat Rev Drug Discov. 2019 May;18(5):339-357. DMYSQMW RU https://pubmed.ncbi.nlm.nih.gov/30728472 DMM7Q68 DI DMM7Q68 DMM7Q68 DN BAY-2253651 DMM7Q68 MI TTGR91N DMM7Q68 MN TWIK-related acid-sensitive potassium channel 1 (TASK1) DMM7Q68 MT DTT DMM7Q68 MA Inhibitor DMM7Q68 RN Antibodies and venom peptides: new modalities for ion channels. Nat Rev Drug Discov. 2019 May;18(5):339-357. DMM7Q68 RU https://pubmed.ncbi.nlm.nih.gov/30728472 DMVA5NS DI DMVA5NS DMVA5NS DN BAY-57-9352 DMVA5NS MI TTI2WET DMVA5NS MN Platelet-derived growth factor receptor (PDGFR) DMVA5NS MT DTT DMVA5NS MA Inhibitor DMVA5NS RN A comparison of physicochemical property profiles of marketed oral drugs and orally bioavailable anti-cancer protein kinase inhibitors in clinical development. Curr Top Med Chem. 2007;7(14):1408-22. DMVA5NS RU https://pubmed.ncbi.nlm.nih.gov/17692029 DMVA5NS DI DMVA5NS DMVA5NS DN BAY-57-9352 DMVA5NS MI TTVJ1D8 DMVA5NS MN Vascular endothelial growth factor receptor (VEGFR) DMVA5NS MT DTT DMVA5NS MA Inhibitor DMVA5NS RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMVA5NS RU http://phrma-docs.phrma.org/sites/default/files/pdf/medicines-in-development-drug-list-rare-diseases.pdf DMVA5NS DI DMVA5NS DMVA5NS DN BAY-57-9352 DMVA5NS MI TTUTJGQ DMVA5NS MN Vascular endothelial growth factor receptor 2 (KDR) DMVA5NS MT DTT DMVA5NS MA Inhibitor DMVA5NS RN A comparison of physicochemical property profiles of marketed oral drugs and orally bioavailable anti-cancer protein kinase inhibitors in clinical development. Curr Top Med Chem. 2007;7(14):1408-22. DMVA5NS RU https://pubmed.ncbi.nlm.nih.gov/17692029 DM7NHLC DI DM7NHLC DM7NHLC DN BAY-85-3934 DM7NHLC MI TTMHFRY DM7NHLC MN HIF-prolyl hydroxylase 1 (HPH-1) DM7NHLC MT DTT DM7NHLC MA Inhibitor DM7NHLC RN Mimicking hypoxia to treat anemia: HIF-stabilizer BAY 85-3934 (Molidustat) stimulates erythropoietin production without hypertensive effects. PLoS One. 2014 Nov 13;9(11):e111838. DM7NHLC RU https://pubmed.ncbi.nlm.nih.gov/25392999 DM2XE80 DI DM2XE80 DM2XE80 DN BAY-X-7195 DM2XE80 MI TTGKOY9 DM2XE80 MN Leukotriene CysLT1 receptor (CYSLTR1) DM2XE80 MT DTT DM2XE80 MA Modulator DM2XE80 RN The effect of a novel leukotriene C4/D4 antagonist, BAY-x-7195, on experimental allergic reactions. Prostaglandins. 1995 Nov-Dec;50(5-6):269-85. DM2XE80 RU https://www.ncbi.nlm.nih.gov/pubmed/8838238 DM2XE80 DI DM2XE80 DM2XE80 DN BAY-X-7195 DM2XE80 MI TT0PZR5 DM2XE80 MN Leukotriene CysLT2 receptor (CYSLTR2) DM2XE80 MT DTT DM2XE80 MA Modulator DM2XE80 RN The effect of a novel leukotriene C4/D4 antagonist, BAY-x-7195, on experimental allergic reactions. Prostaglandins. 1995 Nov-Dec;50(5-6):269-85. DM2XE80 RU https://www.ncbi.nlm.nih.gov/pubmed/8838238 DMLO18H DI DMLO18H DMLO18H DN BAY-Y-5959 DMLO18H MI TTXHYV6 DMLO18H MN Voltage-gated L-type calcium channel (L-CaC) DMLO18H MT DTT DMLO18H MA Modulator DMLO18H RN Hemodynamic effects of a calcium channel promoter, BAY y 5959, are preserved after chronic administration in ischemic heart failure in conscious dogs. J Pharmacol Exp Ther. 1998 Aug;286(2):760-6. DMLO18H RU https://pubmed.ncbi.nlm.nih.gov/9694931 DMB0UF9 DI DMB0UF9 DMB0UF9 DN Bb2121 DMB0UF9 MI TTZ3P4W DMB0UF9 MN B-cell maturation protein (TNFRSF17) DMB0UF9 MT DTT DMB0UF9 MA Immunomodulator DMB0UF9 RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMB0UF9 RU http://phrma-docs.phrma.org/files/dmfile/MID_Immuno-Oncology-2017_Drug-List1.pdf DMR59I4 DI DMR59I4 DMR59I4 DN BBI-5000 DMR59I4 MI TTQDMX5 DMR59I4 MN Prostaglandin D2 receptor 2 (PTGDR2) DMR59I4 MT DTT DMR59I4 MA Antagonist DMR59I4 RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMR59I4 RU http://phrma-docs.phrma.org/files/dmfile/MID_Skin_Diseases_2018_9_FINAL.pdf DMDSNIR DI DMDSNIR DMDSNIR DN BBI503 DMDSNIR MI TTPV9O1 DMDSNIR MN Cancer stemness kinase (CSK) DMDSNIR MT DTT DMDSNIR MA Inhibitor DMDSNIR RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMDSNIR RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DMDSNIR DI DMDSNIR DMDSNIR DN BBI503 DMDSNIR MI TTPMIQ9 DMDSNIR MN Serine/threonine-protein kinase (STK) DMDSNIR MT DTT DMDSNIR MA Inhibitor DMDSNIR RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMDSNIR RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DMY1UGV DI DMY1UGV DMY1UGV DN Bc-3781 intravenous DMY1UGV MI TT2VX74 DMY1UGV MN Bacterial Protein synthesis (Bact PROS) DMY1UGV MT DTT DMY1UGV MA Modulator DMY1UGV RN Antimicrobial activity of the pleuromutilin antibiotic BC-3781 against bacterial pathogens isolated in the SENTRY antimicrobial surveillance program in 2010. Antimicrob Agents Chemother. 2013 Sep;57(9):4489-95. DMY1UGV RU https://pubmed.ncbi.nlm.nih.gov/23836172 DMY1UGV DI DMY1UGV DMY1UGV DN Bc-3781 intravenous DMY1UGV MI DE4LYSA DMY1UGV MN Cytochrome P450 3A4 (CYP3A4) DMY1UGV MT DME DMY1UGV MA Metabolism DMY1UGV RN BC-3781: Evaluation of the CYP3A Interaction Potential. DMY1UGV RU https://www.nabriva.com/Portals/_default/Skins/ProfessionalUs/pdfs/2011-bc-3781-and-cyp3a-interaction-potential.pdf DMMKCJ6 DI DMMKCJ6 DMMKCJ6 DN BC-7013 DMMKCJ6 MI TTUWYEA DMMKCJ6 MN Bacterial 50S ribosomal RNA (Bact 50S rRNA) DMMKCJ6 MT DTT DMMKCJ6 MA Modulator DMMKCJ6 RN Company report (briva) DMMKCJ6 RU http://www.nabriva.com/fileadmin/content/ICAAC_2009/F1-1521_In_vitro_antibacterial_spectrum_of_BC-7013.pdf DM2BO9W DI DM2BO9W DM2BO9W DN BCP-13498 DM2BO9W MI DEJGDUW DM2BO9W MN Cytochrome P450 1A2 (CYP1A2) DM2BO9W MT DME DM2BO9W MA Metabolism DM2BO9W RN Acetaminophen activation by human liver cytochromes P450IIE1 and P450IA2. Arch Biochem Biophys. 1989 Jun;271(2):270-83. DM2BO9W RU https://www.ncbi.nlm.nih.gov/pubmed/?term=2729995 DM2BO9W DI DM2BO9W DM2BO9W DN BCP-13498 DM2BO9W MI DECB0K3 DM2BO9W MN Cytochrome P450 2D6 (CYP2D6) DM2BO9W MT DME DM2BO9W MA Metabolism DM2BO9W RN Involvement of human cytochrome P450 2D6 in the bioactivation of acetaminophen. Drug Metab Dispos. 2000 Dec;28(12):1397-400. DM2BO9W RU https://www.ncbi.nlm.nih.gov/pubmed/?term=11095574 DM2BO9W DI DM2BO9W DM2BO9W DN BCP-13498 DM2BO9W MI DEVDYN7 DM2BO9W MN Cytochrome P450 2E1 (CYP2E1) DM2BO9W MT DME DM2BO9W MA Metabolism DM2BO9W RN Involvement of human cytochrome P450 2D6 in the bioactivation of acetaminophen. Drug Metab Dispos. 2000 Dec;28(12):1397-400. DM2BO9W RU https://www.ncbi.nlm.nih.gov/pubmed/?term=11095574 DM2BO9W DI DM2BO9W DM2BO9W DN BCP-13498 DM2BO9W MI DE0P6LK DM2BO9W MN Sulfotransferase 2A1 (SULT2A1) DM2BO9W MT DME DM2BO9W MA Metabolism DM2BO9W RN Interindividual variability in acetaminophen sulfation by human fetal liver: implications for pharmacogenetic investigations of drug-induced birth defects. Birth Defects Res A Clin Mol Teratol. 2008 Mar;82(3):155-65. DM2BO9W RU https://www.ncbi.nlm.nih.gov/pubmed/?term=18232020 DM2BO9W DI DM2BO9W DM2BO9W DN BCP-13498 DM2BO9W MI DEYGVN4 DM2BO9W MN UDP-glucuronosyltransferase 1A1 (UGT1A1) DM2BO9W MT DME DM2BO9W MA Metabolism DM2BO9W RN Paracetamol glucuronidation by recombinant rat and human phenol UDP-glucuronosyltransferases. Biochem Pharmacol. 1993 May 5;45(9):1809-14. DM2BO9W RU https://www.ncbi.nlm.nih.gov/pubmed/?term=8494539 DM2BO9W DI DM2BO9W DM2BO9W DN BCP-13498 DM2BO9W MI DEL5N6Y DM2BO9W MN UDP-glucuronosyltransferase 1A10 (UGT1A10) DM2BO9W MT DME DM2BO9W MA Metabolism DM2BO9W RN UDP-glucuronosyltransferases and clinical drug-drug interactions. Pharmacol Ther. 2005 Apr;106(1):97-132. DM2BO9W RU https://www.ncbi.nlm.nih.gov/pubmed/?term=15781124 DM2BO9W DI DM2BO9W DM2BO9W DN BCP-13498 DM2BO9W MI DESD26P DM2BO9W MN UDP-glucuronosyltransferase 1A6 (UGT1A6) DM2BO9W MT DME DM2BO9W MA Metabolism DM2BO9W RN Human UGT1A6 pharmacogenetics: identification of a novel SNP, characterization of allele frequencies and functional analysis of recombinant allozymes in human liver tissue and in cultured cells. Pharmacogenetics. 2004 Aug;14(8):487-99. DM2BO9W RU https://www.ncbi.nlm.nih.gov/pubmed/?term=15284531 DM2BO9W DI DM2BO9W DM2BO9W DN BCP-13498 DM2BO9W MI DE85D2P DM2BO9W MN UDP-glucuronosyltransferase 1A9 (UGT1A9) DM2BO9W MT DME DM2BO9W MA Metabolism DM2BO9W RN Polymorphic expression of UGT1A9 is associated with variable acetaminophen glucuronidation in neonates: a population pharmacokinetic and pharmacogenetic study. Clin Pharmacokinet. 2018 Oct;57(10):1325-1336. DM2BO9W RU https://www.ncbi.nlm.nih.gov/pubmed/?term=29654492 DMUFY4K DI DMUFY4K DMUFY4K DN BCT303 DMUFY4K MI TTTSEPU DMUFY4K MN Thyroid hormone receptor alpha (THRA) DMUFY4K MT DTT DMUFY4K MA Modulator DMUFY4K RN Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41. DMUFY4K RU https://www.ncbi.nlm.nih.gov/pubmed/15950434 DMUFY4K DI DMUFY4K DMUFY4K DN BCT303 DMUFY4K MI TTGER3L DMUFY4K MN Thyroid hormone receptor beta (THRB) DMUFY4K MT DTT DMUFY4K MA Modulator DMUFY4K RN Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41. DMUFY4K RU https://www.ncbi.nlm.nih.gov/pubmed/15950434 DMRSG31 DI DMRSG31 DMRSG31 DN BCX-3408 DMRSG31 MI TTMCF1Y DMRSG31 MN Purine nucleoside phosphorylase (PNP) DMRSG31 MT DTT DMRSG31 MA Inhibitor DMRSG31 RN BCX-4208 (RO5092888), a Purine Nucleoside Phosphorylase (PNP) Inhibitor, Is a Novel, Potent Orally Active Anti-T-Cell and B-Cell Agent. 50th ASH Annual Meeting and Exposition. 2008. DMRSG31 RU http://ash.confex.com/ash/2008/webprogram/Paper7315.html DMKFJXP DI DMKFJXP DMKFJXP DN BDB001 DMKFJXP MI TTOK0LR DMKFJXP MN Toll-like receptor (TLR) DMKFJXP MT DTT DMKFJXP MA Agonist DMKFJXP RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMKFJXP RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DM2Q50G DI DM2Q50G DM2Q50G DN Belnacasan DM2Q50G MI TTCQIBE DM2Q50G MN Caspase-1 (CASP1) DM2Q50G MT DTT DM2Q50G MA Inhibitor DM2Q50G RN (S)-1-((S)-2-{[1-(4-amino-3-chloro-phenyl)-methanoyl]-amino}-3,3-dimethyl-butanoyl)-pyrrolidine-2-carboxylic acid ((2R,3S)-2-ethoxy-5-oxo-tetrahydr... J Pharmacol Exp Ther. 2007 May;321(2):509-16. DM2Q50G RU https://pubmed.ncbi.nlm.nih.gov/17289835 DMWNYIE DI DMWNYIE DMWNYIE DN Bemarituzumab DMWNYIE MI TTGKIED DMWNYIE MN Fibroblast growth factor-2 (FGF2) DMWNYIE MT DTT DMWNYIE MA Antagonist DMWNYIE RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMWNYIE RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DM0YCPL DI DM0YCPL DM0YCPL DN Bemcentinib DM0YCPL MI TTZPY6J DM0YCPL MN Tyrosine-protein kinase UFO (AXL) DM0YCPL MT DTT DM0YCPL MA Inhibitor DM0YCPL RN AXL Targeting Abrogates Autophagic Flux and Induces Immunogenic Cell Death in Drug-Resistant Cancer Cells. J Thorac Oncol. 2020 Jun;15(6):973-999. DM0YCPL RU https://pubmed.ncbi.nlm.nih.gov/32018052 DMUL6GY DI DMUL6GY DMUL6GY DN BEMORADAN DMUL6GY MI TT06AWU DMUL6GY MN Phosphodiesterase 3A (PDE3A) DMUL6GY MT DTT DMUL6GY MA Inhibitor DMUL6GY RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015 DMUL6GY RU https://www.accessdata.fda.gov/scripts/cder/drugsatfda/ DMRC0EQ DI DMRC0EQ DMRC0EQ DN Bertilimumab DMRC0EQ MI TTCF05Y DMRC0EQ MN Small-inducible cytokine A11 (CCL11) DMRC0EQ MT DTT DMRC0EQ MA Modulator DMRC0EQ RN Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41. DMRC0EQ RU https://www.ncbi.nlm.nih.gov/pubmed/15950434 DMJ2REU DI DMJ2REU DMJ2REU DN Berubicin DMJ2REU MI TT0IHXV DMJ2REU MN DNA topoisomerase II (TOP2) DMJ2REU MT DTT DMJ2REU MA Modulator DMJ2REU RN Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41. DMJ2REU RU https://www.ncbi.nlm.nih.gov/pubmed/15950434 DM7583A DI DM7583A DM7583A DN Beta-caryophyllene DM7583A MI TTMSFAW DM7583A MN Cannabinoid receptor 2 (CB2) DM7583A MT DTT DM7583A MA Agonist DM7583A RN The cannabinoid CB1 receptor-selective phytocannabinoid beta-caryophyllene exerts analgesic effects in mouse models of inflammatory and neuropathic pain. Eur Neuropsychopharmacol. 2014 Apr;24(4):608-20. DM7583A RU https://pubmed.ncbi.nlm.nih.gov/24210682 DMMI84K DI DMMI84K DMMI84K DN Beta-lapachone DMMI84K MI TTGTQHC DMMI84K MN DNA topoisomerase I (TOP1) DMMI84K MT DTT DMMI84K MA Modulator DMMI84K RN Cancer therapy with beta-lapachone. Curr Cancer Drug Targets. 2002 Sep;2(3):227-42. DMMI84K RU https://pubmed.ncbi.nlm.nih.gov/12188909 DMMI84K DI DMMI84K DMMI84K DN Beta-lapachone DMMI84K MI DENP5RY DMMI84K MN Quinone reductase 1 (NQO1) DMMI84K MT DME DMMI84K MA Metabolism DMMI84K RN Beta-lapachone, a modulator of NAD metabolism, prevents health declines in aged mice. PLoS One. 2012;7(10):e47122. DMMI84K RU https://www.ncbi.nlm.nih.gov/pubmed/?term=23071729 DML2D8Q DI DML2D8Q DML2D8Q DN Bevirimat DML2D8Q MI TTFGZB6 DML2D8Q MN Human immunodeficiency virus GAG protein (HIV gag) DML2D8Q MT DTT DML2D8Q MA Inhibitor DML2D8Q RN Synthesis and biological evaluation of a new derivative of bevirimat that targets the Gag CA-SP1 cleavage site. Eur J Med Chem. 2013 Apr;62:453-65. DML2D8Q RU https://pubmed.ncbi.nlm.nih.gov/23399723 DML2D8Q DI DML2D8Q DML2D8Q DN Bevirimat DML2D8Q MI DEF2WXN DML2D8Q MN UDP-glucuronosyltransferase 1A3 (UGT1A3) DML2D8Q MT DME DML2D8Q MA Metabolism DML2D8Q RN Bevirimat: a novel maturation inhibitor for the treatment of HIV-1 infection. Antivir Chem Chemother. 2008;19(3):107-13. DML2D8Q RU https://www.intmedpress.com/serveFile.cfm?sUID=ebccbb0b-de4a-42d4-ae2b-ca2304d75f56 DML2D8Q DI DML2D8Q DML2D8Q DN Bevirimat DML2D8Q MI DELOY3P DML2D8Q MN UDP-glucuronosyltransferase 1A4 (UGT1A4) DML2D8Q MT DME DML2D8Q MA Metabolism DML2D8Q RN Bevirimat: a novel maturation inhibitor for the treatment of HIV-1 infection. Antivir Chem Chemother. 2008;19(3):107-13. DML2D8Q RU https://www.intmedpress.com/serveFile.cfm?sUID=ebccbb0b-de4a-42d4-ae2b-ca2304d75f56 DML2D8Q DI DML2D8Q DML2D8Q DN Bevirimat DML2D8Q MI DEB3CV1 DML2D8Q MN UDP-glucuronosyltransferase 2B7 (UGT2B7) DML2D8Q MT DME DML2D8Q MA Metabolism DML2D8Q RN Bevirimat: a novel maturation inhibitor for the treatment of HIV-1 infection. Antivir Chem Chemother. 2008;19(3):107-13. DML2D8Q RU https://www.intmedpress.com/serveFile.cfm?sUID=ebccbb0b-de4a-42d4-ae2b-ca2304d75f56 DMKBRDL DI DMKBRDL DMKBRDL DN BEZ235 DMKBRDL MI TTHBTOP DMKBRDL MN PI3-kinase gamma (PIK3CG) DMKBRDL MT DTT DMKBRDL MA Modulator DMKBRDL RN The dual PI3K/mTOR inhibitor NVP-BEZ235 is a potent inhibitor of ATM- and DNA-PKCs-mediated DNA damage responses. Neoplasia. 2012 Jan;14(1):34-43. DMKBRDL RU https://www.ncbi.nlm.nih.gov/pubmed/22355272 DMKBRDL DI DMKBRDL DMKBRDL DN BEZ235 DMKBRDL MI TTCJG29 DMKBRDL MN Serine/threonine-protein kinase mTOR (mTOR) DMKBRDL MT DTT DMKBRDL MA Modulator DMKBRDL RN The dual PI3K/mTOR inhibitor NVP-BEZ235 is a potent inhibitor of ATM- and DNA-PKCs-mediated DNA damage responses. Neoplasia. 2012 Jan;14(1):34-43. DMKBRDL RU https://www.ncbi.nlm.nih.gov/pubmed/22355272 DMVUX1C DI DMVUX1C DMVUX1C DN BFH-772 DMVUX1C MI TTVJ1D8 DMVUX1C MN Vascular endothelial growth factor receptor (VEGFR) DMVUX1C MT DTT DMVUX1C MA Agonist DMVUX1C RN CA patent application no. 841416, Method of selecting therapeutic indications. DMVUX1C RU http://www.google.com/patents/CA2841416A1?cl=en DMRO6XT DI DMRO6XT DMRO6XT DN BGB-290 DMRO6XT MI TTEBCY8 DMRO6XT MN Poly [ADP-ribose] polymerase (PARP) DMRO6XT MT DTT DMRO6XT MA Inhibitor DMRO6XT RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMRO6XT RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DMRO6XT DI DMRO6XT DMRO6XT DN BGB-290 DMRO6XT MI TTKSAQZ DMRO6XT MN Tankyrase (TNKS) DMRO6XT MT DTT DMRO6XT MA Modulator DMRO6XT RN National Cancer Institute Drug Dictionary (drug id 769217). DMRO6XT RU http://www.cancer.gov/publications/dictionaries/cancer-drug?cdrid=769217 DMQCFSM DI DMQCFSM DMQCFSM DN BGB-3112 DMQCFSM MI TTGM6VW DMQCFSM MN Tyrosine-protein kinase BTK (ATK) DMQCFSM MT DTT DMQCFSM MA Inhibitor DMQCFSM RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMQCFSM RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DMDI43Y DI DMDI43Y DMDI43Y DN BGB-324 DMDI43Y MI TTZPY6J DMDI43Y MN Tyrosine-protein kinase UFO (AXL) DMDI43Y MT DTT DMDI43Y RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1835). DMDI43Y RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1835 DM1X3L0 DI DM1X3L0 DM1X3L0 DN BGB-3245 DM1X3L0 MI TTB18GJ DM1X3L0 MN Proto-oncogene c-RAF (c-RAF) DM1X3L0 MT DTT DM1X3L0 MA Inhibitor DM1X3L0 RN Clinical pipeline report, company report or official report of BeiGene. DM1X3L0 RU https://www.beigene.com/science-and-product-portfolio/pipeline DMS2MQ5 DI DMS2MQ5 DMS2MQ5 DN BGC-20-1531 DMS2MQ5 MI TT79WV3 DMS2MQ5 MN Prostaglandin E2 receptor EP4 (PTGER4) DMS2MQ5 MT DTT DMS2MQ5 MA Antagonist DMS2MQ5 RN BGC20-1531, a novel, potent and selective prostanoid EP4 receptor antagonist: a putative new treatment for migraine headache. Br J Pharmacol. 2009 January; 156(2): 316-327. DMS2MQ5 RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2697835/ DMYDM68 DI DMYDM68 DMYDM68 DN BGP-15 DMYDM68 MI TTR2TXZ DMYDM68 MN Jun N terminal kinase (JNK) DMYDM68 MT DTT DMYDM68 MA Inhibitor DMYDM68 RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMYDM68 RU http://phrma-docs.phrma.org/files/dmfile/mid-diabetes-drug-list.pdf DMYDM68 DI DMYDM68 DMYDM68 DN BGP-15 DMYDM68 MI TTEBCY8 DMYDM68 MN Poly [ADP-ribose] polymerase (PARP) DMYDM68 MT DTT DMYDM68 MA Modulator DMYDM68 RN BGP-15, a PARP-inhibitor, prevents imatinib-induced cardiotoxicity by activating Akt and suppressing JNK and p38 MAP kinases. Mol Cell Biochem. 2012 Jun;365(1-2):129-37. DMYDM68 RU https://pubmed.ncbi.nlm.nih.gov/22350755 DMO4MNQ DI DMO4MNQ DMO4MNQ DN BGS-649 DMO4MNQ MI TTSZLWK DMO4MNQ MN Aromatase (CYP19A1) DMO4MNQ MT DTT DMO4MNQ MA Inhibitor DMO4MNQ RN Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800032111) DMO4MNQ RU http://adisinsight.springer.com/drugs/800032111 DMSROM4 DI DMSROM4 DMSROM4 DN BHQ880 DMSROM4 MI TTE3RAC DMSROM4 MN Dickkopf-related protein 1 (DKK1) DMSROM4 MT DTT DMSROM4 MA Inhibitor DMSROM4 RN Anti-DKK1 mAb (BHQ880) as a potential therapeutic agent for multiple myeloma. Blood. 2009 Jul 9;114(2):371-9. DMSROM4 RU https://pubmed.ncbi.nlm.nih.gov/19417213 DM7ZM1H DI DM7ZM1H DM7ZM1H DN BHT-3009 DM7ZM1H MI TT2RY5P DM7ZM1H MN Myelin basic protein (MBP) DM7ZM1H MT DTT DM7ZM1H RN BHT-3009, a myelin basic protein-encoding plasmid for the treatment of multiple sclerosis. Curr Opin Mol Ther. 2009 Aug;11(4):463-70. DM7ZM1H RU https://pubmed.ncbi.nlm.nih.gov/19649992 DM740BS DI DM740BS DM740BS DN BI 1358894 DM740BS MI TTX0H5W DM740BS MN Short transient receptor potential channel 4 (TRPC4) DM740BS MT DTT DM740BS MA Inhibitor DM740BS RN Clinical pipeline report, company report or official report of Boehringer Ingelheim. DM740BS RU https://www.boehringer-ingelheim.pt/press-release/hydra-biosciences-and-boehringer-ingelheim-announce-worldwide-collaboration-develop DM740BS DI DM740BS DM740BS DN BI 1358894 DM740BS MI TT32NQ1 DM740BS MN Short transient receptor potential channel 5 (TRPC5) DM740BS MT DTT DM740BS MA Inhibitor DM740BS RN Clinical pipeline report, company report or official report of Boehringer Ingelheim. DM740BS RU https://www.boehringer-ingelheim.pt/press-release/hydra-biosciences-and-boehringer-ingelheim-announce-worldwide-collaboration-develop DMMSGAT DI DMMSGAT DMMSGAT DN BI 207127 DMMSGAT MI TTMVBWH DMMSGAT MN Hepatitis C virus RNA-directed RNA polymerase (HCV NS5B) DMMSGAT MT DTT DMMSGAT MA Inhibitor DMMSGAT RN 2011 Pipeline of Boehringer Ingelheim Pharma. DMMSGAT RU http://www.boehringer-ingelheim.com/ DMJSADP DI DMJSADP DMJSADP DN BI 2536 DMJSADP MI TTIYVQP DMJSADP MN Polo-like kinase 1 (PLK1) DMJSADP MT DTT DMJSADP MA Inhibitor DMJSADP RN Polo-like kinase (PLK) inhibitors in preclinical and early clinical development in oncology. Oncologist. 2009 Jun;14(6):559-70. DMJSADP RU https://pubmed.ncbi.nlm.nih.gov/19474163 DM1NMGJ DI DM1NMGJ DM1NMGJ DN BI 456906 DM1NMGJ MI TTVIMDE DM1NMGJ MN Glucagon-like peptide 1 receptor (GLP1R) DM1NMGJ MT DTT DM1NMGJ MA Agonist DM1NMGJ RN Clinical pipeline report, company report or official report of Boehringer Ingelheim. DM1NMGJ RU https://www.boehringer-ingelheim.us/press-release/boehringer-ingelheim-and-zealand-pharma-advance-dual-acting-glp-1glucagon-agonist-bi DMF86P2 DI DMF86P2 DMF86P2 DN BI 655064 DMF86P2 MI TTN6Y9A DMF86P2 MN CD40L receptor (CD40) DMF86P2 MT DTT DMF86P2 MA Inhibitor DMF86P2 RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMF86P2 RU http://phrma-docs.phrma.org/files/dmfile/medicines-in-development-drug-list-autoimmune-diseases.pdf DMF86P2 DI DMF86P2 DMF86P2 DN BI 655064 DMF86P2 MI TTIJP3Q DMF86P2 MN TNF related activation protein (CD40LG) DMF86P2 MT DTT DMF86P2 RN FRI0167 Patient-Reported Outcomes (PROS) During Treatment with Mavrilimumab, A Fully Human Monoclonal Antibody Targeting GMCSFR-Alpha, In the Phase IIB Earth Explorer 1 Study DMF86P2 RU http://ard.bmj.com/content/74/Suppl_2/483.3.abstract DMJFDS0 DI DMJFDS0 DMJFDS0 DN BI-409306 DMJFDS0 MI TTZOEBC DMJFDS0 MN Phosphodiesterase 9 (PDE9) DMJFDS0 MT DTT DMJFDS0 MA Inhibitor DMJFDS0 RN Clinical pipeline report, company report or official report of Boehringer Ingelheim pipeline. DMJFDS0 RU https://www.boehringer-ingelheim.com/research_development/drug_discovery/pipeline.html DMZR9OU DI DMZR9OU DMZR9OU DN BI-44370 DMZR9OU MI TTY6O0Q DMZR9OU MN Calcitonin gene-related peptide receptor (CGRPR) DMZR9OU MT DTT DMZR9OU MA Antagonist DMZR9OU RN BI 44370 TA, an oral CGRP antagonist for the treatment of acute migraine attacks: results from a phase II study. Cephalalgia. 2011 Apr;31(5):573-84. DMZR9OU RU https://pubmed.ncbi.nlm.nih.gov/21172952 DMSZQHX DI DMSZQHX DMSZQHX DN BI-505 DMSZQHX MI TTCT6F7 DMSZQHX MN Intercellular adhesion molecule ICAM-1 (ICAM1) DMSZQHX MT DTT DMSZQHX RN A human ICAM-1 antibody isolated by a function-first approach has potent macrophage-dependent antimyeloma activity in vivo. Cancer Cell. 2013 Apr 15;23(4):502-15. DMSZQHX RU https://pubmed.ncbi.nlm.nih.gov/23597564 DMSZQHX DI DMSZQHX DMSZQHX DN BI-505 DMSZQHX MI TTZPY6J DMSZQHX MN Tyrosine-protein kinase UFO (AXL) DMSZQHX MT DTT DMSZQHX MA Inhibitor DMSZQHX RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMSZQHX RU http://phrma-docs.phrma.org/sites/default/files/pdf/medicines-in-development-drug-list-rare-diseases.pdf DM9FZYT DI DM9FZYT DM9FZYT DN BI-655130 DM9FZYT MI TTUS18T DM9FZYT MN IL-1 receptor-like 2 (IL1RL2) DM9FZYT MT DTT DM9FZYT MA Antagonist DM9FZYT RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DM9FZYT RU http://phrma-docs.phrma.org/files/dmfile/MID_Skin_Diseases_2018_9_FINAL.pdf DMWH7Z5 DI DMWH7Z5 DMWH7Z5 DN BI-836826 DMWH7Z5 MI TTFCW29 DMWH7Z5 MN Leukocyte antigen CD37 (CD37) DMWH7Z5 MT DTT DMWH7Z5 RN Anti-CD37 antibodies for chronic lymphocytic leukemia. Expert Opin Biol Ther. 2014 May;14(5):651-61. DMWH7Z5 RU https://pubmed.ncbi.nlm.nih.gov/24555705 DMUVMY9 DI DMUVMY9 DMUVMY9 DN BI-836858 DMUVMY9 MI TTJVYO3 DMUVMY9 MN Myeloid cell surface antigen CD33 (CD33) DMUVMY9 MT DTT DMUVMY9 RN The past and future of CD33 as therapeutic target in acute myeloid leukemia. Blood Rev. 2014 Jul;28(4):143-53. DMUVMY9 RU https://pubmed.ncbi.nlm.nih.gov/24809231 DMG3ON2 DI DMG3ON2 DMG3ON2 DN BIA 3-202 DMG3ON2 MI TTKWFB8 DMG3ON2 MN Catechol-O-methyl-transferase (COMT) DMG3ON2 MT DTT DMG3ON2 MA Inhibitor DMG3ON2 RN Chemical synthesis and characterization of conjugates of a novel catechol-O-methyltransferase inhibitor. Bioconjug Chem. 2002 Sep-Oct;13(5):1112-8. DMG3ON2 RU https://pubmed.ncbi.nlm.nih.gov/12236793 DMHYZEK DI DMHYZEK DMHYZEK DN BIBH 1 DMHYZEK MI TTGPQ0F DMHYZEK MN Prolyl endopeptidase FAP (FAP) DMHYZEK MT DTT DMHYZEK RN A Phase I dose-escalation study of sibrotuzumab in patients with advanced or metastatic fibroblast activation protein-positive cancer. Clin Cancer Res. 2003 May;9(5):1639-47. DMHYZEK RU https://pubmed.ncbi.nlm.nih.gov/12738716 DM9OXEJ DI DM9OXEJ DM9OXEJ DN BIIB 023 DM9OXEJ MI TTBTDM1 DM9OXEJ MN TNF-related weak inducer of apoptosis (TWEAK) DM9OXEJ MT DTT DM9OXEJ MA Modulator DM9OXEJ RN ClinicalTrials.gov (NCT00771329) BIIB023 (Anti-TWEAK) in Subjects With Rheumatoid Arthritis. U.S. National Institutes of Health. DM9OXEJ RU https://clinicaltrials.gov/ct2/show/NCT00771329 DM293JT DI DM293JT DM293JT DN BIIB 033 DM293JT MI TTZYQ80 DM293JT MN Leucine-rich repeat neuronal protein 1 (LINGO1) DM293JT MT DTT DM293JT RN Randomized phase I trials of the safety/tolerability of anti-LINGO-1 monoclonal antibody BIIB033. Neurol Neuroimmunol Neuroinflamm. 2014 Aug 21;1(2):e18. DM293JT RU https://pubmed.ncbi.nlm.nih.gov/25340070 DMH7RJ1 DI DMH7RJ1 DMH7RJ1 DN BIIB014 DMH7RJ1 MI TTM2AOE DMH7RJ1 MN Adenosine A2a receptor (ADORA2A) DMH7RJ1 MT DTT DMH7RJ1 MA Antagonist DMH7RJ1 RN Novel pharmacological targets for the treatment of Parkinson's disease. Nat Rev Drug Discov. 2006 Oct;5(10):845-54. DMH7RJ1 RU https://pubmed.ncbi.nlm.nih.gov/17016425 DMH7RJ1 DI DMH7RJ1 DMH7RJ1 DN BIIB014 DMH7RJ1 MI DE4LYSA DMH7RJ1 MN Cytochrome P450 3A4 (CYP3A4) DMH7RJ1 MT DME DMH7RJ1 MA Metabolism DMH7RJ1 RN Frontiers in CNS Drug Discovery. Edited by Atta-ur Rahman, M. Iqbal Choudhary. Page: 318. DMH7RJ1 RU https://books.google.nl/books?id=ip-Pz5C3_loC&pg=PA318&lpg=PA318&dq=BIIB014++metabolizing+enzyme&source=bl&ots=G8YeDCzw5_&sig=ACfU3U1ZkEaPcDy58jtvOlzdzR-s3sNz4g&hl=zh-CN&sa=X&ved=2ahUKEwiGkem-7rnnAhVP4qQKHfNzAi4Q6AEwFXoECAwQAQ#v=onepage&q=BIIB014%20%20metabolizing%20enzyme&f=false DMPAJ41 DI DMPAJ41 DMPAJ41 DN BIIB-021 DMPAJ41 MI TT78R5H DMPAJ41 MN Heat shock protein 90 alpha (HSP90A) DMPAJ41 MT DTT DMPAJ41 MA Inhibitor DMPAJ41 RN BIIB021, an orally available, fully synthetic small-molecule inhibitor of the heat shock protein Hsp90. Mol Cancer Ther. 2009 Apr;8(4):921-9. DMPAJ41 RU https://pubmed.ncbi.nlm.nih.gov/19372565 DMZO2SY DI DMZO2SY DMZO2SY DN BIIB054 DMZO2SY MI TT08OSU DMZO2SY MN Synuclein alpha (SNCA) DMZO2SY MT DTT DMZO2SY MA Inhibitor DMZO2SY RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMZO2SY RU http://phrma-docs.phrma.org/files/dmfile/MID_Neurological-Disorders-Drug-List_2018.pdf DMLV1ET DI DMLV1ET DMLV1ET DN BIIB074 DMLV1ET MI TT4G2JS DMLV1ET MN Voltage-gated sodium channel alpha Nav1.7 (SCN9A) DMLV1ET MT DTT DMLV1ET MA Inhibitor DMLV1ET RN Antibodies and venom peptides: new modalities for ion channels. Nat Rev Drug Discov. 2019 May;18(5):339-357. DMLV1ET RU https://pubmed.ncbi.nlm.nih.gov/30728472 DM263RP DI DM263RP DM263RP DN BIIB092 DM263RP MI TTS87KH DM263RP MN Microtubule-associated protein tau (MAPT) DM263RP MT DTT DM263RP MA Inhibitor DM263RP RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DM263RP RU http://phrma-docs.phrma.org/files/dmfile/MID_Neurological-Disorders-Drug-List_2018.pdf DM2J36F DI DM2J36F DM2J36F DN BILN-2061 DM2J36F MI TTWXB3E DM2J36F MN Hepatitis C virus NS3 helicase (HCV NS3) DM2J36F MT DTT DM2J36F MA Inhibitor DM2J36F RN Antiviral efficacy of NS3-serine protease inhibitor BILN-2061 in patients with chronic genotype 2 and 3 hepatitis C. Hepatology. 2005 Apr;41(4):832-5. DM2J36F RU https://pubmed.ncbi.nlm.nih.gov/15732092 DMAG4SX DI DMAG4SX DMAG4SX DN BILR-355 DMAG4SX MI TT84ETX DMAG4SX MN Human immunodeficiency virus Reverse transcriptase (HIV RT) DMAG4SX MT DTT DMAG4SX MA Inhibitor DMAG4SX RN Evaluation of steady-state pharmacokinetic interactions between ritonavir-boosted BILR 355, a non-nucleoside reverse transcriptase inhibitor, and lamivudine/zidovudine in healthy subjects. J Clin Pharm Ther. 2012 Feb;37(1):81-8. DMAG4SX RU https://pubmed.ncbi.nlm.nih.gov/21128991 DM6EIZG DI DM6EIZG DM6EIZG DN BIM23A760 DM6EIZG MI TT2J34L DM6EIZG MN Arachidonate 5-lipoxygenase (5-LOX) DM6EIZG MT DTT DM6EIZG MA Inhibitor DM6EIZG RN Preview of potential therapeutic applications of leukotriene B4 inhibitors in dermatology. Skin Pharmacol Appl Skin Physiol. 2000 Sep-Oct;13(5):235-45. DM6EIZG RU https://pubmed.ncbi.nlm.nih.gov/10940813 DM6EIZG DI DM6EIZG DM6EIZG DN BIM23A760 DM6EIZG MI TTEX248 DM6EIZG MN Dopamine D2 receptor (D2R) DM6EIZG MT DTT DM6EIZG MA Modulator DM6EIZG RN BIM-23A760, a chimeric molecule directed towards somatostatin and dopamine receptors, vs universal somatostatin receptors ligands in GH-secreting pituitary adenomas partial responders to octreotide. J Endocrinol Invest. 2005;28(11 Suppl International):21-7. DM6EIZG RU https://pubmed.ncbi.nlm.nih.gov/16625841 DMH7Q4E DI DMH7Q4E DMH7Q4E DN Bimagrumab DMH7Q4E MI TTRG4QN DMH7Q4E MN Activin receptor type II (ACVR2) DMH7Q4E MT DTT DMH7Q4E MA Inhibitor DMH7Q4E RN Effects of bimagrumab, an activin receptor type II inhibitor, on pituitary neurohormonal axes. Clin Endocrinol (Oxf). 2018 Jun;88(6):908-919. DMH7Q4E RU https://pubmed.ncbi.nlm.nih.gov/29566437 DMBRL19 DI DMBRL19 DMBRL19 DN Bimakalim DMBRL19 MI TT1VOHK DMBRL19 MN Potassium channel unspecific (KC) DMBRL19 MT DTT DMBRL19 MA Agonist DMBRL19 RN Lack of anti-ischemic efficacy of the potassium channel opener bimakalim in patients with stable angina pectoris. Cardiovasc Drugs Ther. 2004 Jan;18(1):37-46. DMBRL19 RU https://pubmed.ncbi.nlm.nih.gov/15115902 DMB9LRJ DI DMB9LRJ DMB9LRJ DN Bintrafusp alfa DMB9LRJ MI TT8ZLTI DMB9LRJ MN Programmed cell death 1 ligand 1 (PD-L1) DMB9LRJ MT DTT DMB9LRJ RN Bintrafusp Alfa, a Bifunctional Fusion Protein Targeting TGF- and PD-L1, in Second-Line Treatment of Patients With NSCLC: Results From an Expansion Cohort of a Phase 1 Trial. J Thorac Oncol. 2020 Jul;15(7):1210-1222. DMB9LRJ RU https://pubmed.ncbi.nlm.nih.gov/32173464 DMB9LRJ DI DMB9LRJ DMB9LRJ DN Bintrafusp alfa DMB9LRJ MI TTO3HT7 DMB9LRJ MN Transforming growth factor beta (TGFB) DMB9LRJ MT DTT DMB9LRJ RN Bintrafusp Alfa, a Bifunctional Fusion Protein Targeting TGF- and PD-L1, in Second-Line Treatment of Patients With NSCLC: Results From an Expansion Cohort of a Phase 1 Trial. J Thorac Oncol. 2020 Jul;15(7):1210-1222. DMB9LRJ RU https://pubmed.ncbi.nlm.nih.gov/32173464 DM6N05H DI DM6N05H DM6N05H DN BIO-11006 DM6N05H MI TTHRM39 DM6N05H MN Myristoylated alanine-rich C-kinase substrate (MARCKS) DM6N05H MT DTT DM6N05H MA Inhibitor DM6N05H RN Inhibition of myristoylated alanine-rich C kinase substrate (MARCKS) protein inhibits ozone-induced airway neutrophilia and inflammation. Exp Lung Res. 2010 Mar;36(2):75-84. DM6N05H RU https://pubmed.ncbi.nlm.nih.gov/20205598 DMPNYXQ DI DMPNYXQ DMPNYXQ DN BIO-11006 DMPNYXQ MI TTHRM39 DMPNYXQ MN Myristoylated alanine-rich C-kinase substrate (MARCKS) DMPNYXQ MT DTT DMPNYXQ MA Inhibitor DMPNYXQ RN An Inhaled Inhibitor of Myristoylated Alanine-Rich C Kinase Substrate Reverses LPS-Induced Acute Lung Injury in Mice. Am J Respir Cell Mol Biol. 2016 Nov;55(5):617-622. DMPNYXQ RU https://pubmed.ncbi.nlm.nih.gov/27556883 DMKICA3 DI DMKICA3 DMKICA3 DN BIO-1211 DMKICA3 MI TT4BT06 DMKICA3 MN Integrin alpha-4 (ITGA4) DMKICA3 MT DTT DMKICA3 MA Antagonist DMKICA3 RN A small-molecule, tight-binding inhibitor of the integrin alpha(4)beta(1) blocks antigen-induced airway responses and inflammation in experimental asthma in sheep. Am J Respir Crit Care Med. 2000 Aug;162(2 Pt 1):603-11. DMKICA3 RU https://pubmed.ncbi.nlm.nih.gov/10934094 DM7PT8R DI DM7PT8R DM7PT8R DN BioE-743 DM7PT8R MI TT8XK6L DM7PT8R MN Quinone reductase 1 (NQO1) DM7PT8R MT DTT DM7PT8R MA Modulator DM7PT8R RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DM7PT8R RU http://phrma-docs.phrma.org/files/dmfile/MID_Neurological-Disorders-Drug-List_2018.pdf DM6PBUM DI DM6PBUM DM6PBUM DN Birinapant DM6PBUM MI TTQ5LRD DM6PBUM MN Cellular inhibitor of apoptosis 1 (BIRC2) DM6PBUM MT DTT DM6PBUM MA Modulator DM6PBUM RN cIAPs and XIAP regulate myelopoiesis through cytokine production in an RIPK1- and RIPK3-dependent manner. Blood. 2014 Apr 17;123(16):2562-72. DM6PBUM RU https://pubmed.ncbi.nlm.nih.gov/24497535 DM6PBUM DI DM6PBUM DM6PBUM DN Birinapant DM6PBUM MI TTR7B60 DM6PBUM MN X-linked inhibitor of apoptosis protein (XIAP) DM6PBUM MT DTT DM6PBUM MA Modulator DM6PBUM RN cIAPs and XIAP regulate myelopoiesis through cytokine production in an RIPK1- and RIPK3-dependent manner. Blood. 2014 Apr 17;123(16):2562-72. DM6PBUM RU https://pubmed.ncbi.nlm.nih.gov/24497535 DMW76V0 DI DMW76V0 DMW76V0 DN Bisantrene DMW76V0 MI DTI7UX6 DMW76V0 MN Breast cancer resistance protein (ABCG2) DMW76V0 MT DTP DMW76V0 MA Substrate DMW76V0 RN Pharmacogenomic importance of ABCG2. Pharmacogenomics. 2008 Aug;9(8):1005-9. DMW76V0 RU https://doi.org/10.2217/14622416.9.8.1005 DMW76V0 DI DMW76V0 DMW76V0 DN Bisantrene DMW76V0 MI DTUGYRD DMW76V0 MN P-glycoprotein 1 (ABCB1) DMW76V0 MT DTP DMW76V0 MA Substrate DMW76V0 RN Mammalian drug efflux transporters of the ATP binding cassette (ABC) family in multidrug resistance: A review of the past decade. Cancer Lett. 2016 Jan 1;370(1):153-64. DMW76V0 RU http://www.ncbi.nlm.nih.gov/pubmed/26499806 DMVDO93 DI DMVDO93 DMVDO93 DN BL-1020 DMVDO93 MI TTEX248 DMVDO93 MN Dopamine D2 receptor (D2R) DMVDO93 MT DTT DMVDO93 MA Antagonist DMVDO93 RN The pipeline and future of drug development in schizophrenia. Mol Psychiatry. 2007 Oct;12(10):904-22. DMVDO93 RU https://pubmed.ncbi.nlm.nih.gov/17667958 DMVDO93 DI DMVDO93 DMVDO93 DN BL-1020 DMVDO93 MI TTNJYV2 DMVDO93 MN Gamma-aminobutyric acid receptor (GAR) DMVDO93 MT DTT DMVDO93 MA Agonist DMVDO93 RN The pipeline and future of drug development in schizophrenia. Mol Psychiatry. 2007 Oct;12(10):904-22. DMVDO93 RU https://pubmed.ncbi.nlm.nih.gov/17667958 DM8R71T DI DM8R71T DM8R71T DN BL-22 DM8R71T MI TTM6QSK DM8R71T MN B-cell receptor CD22 (CD22) DM8R71T MT DTT DM8R71T RN Anti-CD22 immunotoxin RFB4(dsFv)-PE38 (BL22) for CD22-positive hematologic malignancies of childhood: preclinical studies and phase I clinical trial. Clin Cancer Res. 2010 Mar 15;16(6):1894-903. DM8R71T RU https://pubmed.ncbi.nlm.nih.gov/20215554 DMSBPJI DI DMSBPJI DMSBPJI DN BL-7040 DMSBPJI MI TTSHG0T DMSBPJI MN Toll-like receptor 9 (TLR9) DMSBPJI MT DTT DMSBPJI MA Activator DMSBPJI RN Gut feeling: MicroRNA discriminators of the intestinal TLR9-cholinergic links. Int Immunopharmacol. 2015 Nov;29(1):8-14. DMSBPJI RU https://pubmed.ncbi.nlm.nih.gov/26003847 DMKO0BQ DI DMKO0BQ DMKO0BQ DN BLD-2660 DMKO0BQ MI TT45V0U DMKO0BQ MN HUMAN calpain-1/calpain small subunit 1 heterodimer (CAPN1/CAPNS1) DMKO0BQ MT DTT DMKO0BQ MA Inhibitor DMKO0BQ RN ClinicalTrials.gov (NCT04334460) Safety and Antiviral Activity of BLD-2660 in COVID-19 Hospitalized Subjects. U.S. National Institutes of Health. DMKO0BQ RU https://clinicaltrials.gov/ct2/show/NCT04334460 DMKO0BQ DI DMKO0BQ DMKO0BQ DN BLD-2660 DMKO0BQ MI TTO361H DMKO0BQ MN HUMAN calpain-2/calpain small subunit 1 heterodimer (CAPN2/CAPNS1) DMKO0BQ MT DTT DMKO0BQ MA Inhibitor DMKO0BQ RN ClinicalTrials.gov (NCT04334460) Safety and Antiviral Activity of BLD-2660 in COVID-19 Hospitalized Subjects. U.S. National Institutes of Health. DMKO0BQ RU https://clinicaltrials.gov/ct2/show/NCT04334460 DMYK1DR DI DMYK1DR DMYK1DR DN BLI-1005 DMYK1DR MI TTAWNKZ DMYK1DR MN Norepinephrine transporter (NET) DMYK1DR MT DTT DMYK1DR MA Inhibitor DMYK1DR RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMYK1DR RU http://phrma-docs.phrma.org/files/dmfile/MID_Mental-Illness-2017-Drug-List_Final.pdf DMG1LVA DI DMG1LVA DMG1LVA DN BLZ-945 DMG1LVA MI TTC70AJ DMG1LVA MN Granulocyte colony-stimulating factor receptor (G-CSF-R) DMG1LVA MT DTT DMG1LVA MA Inhibitor DMG1LVA RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1719). DMG1LVA RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1719 DMG1LVA DI DMG1LVA DMG1LVA DN BLZ-945 DMG1LVA MI TT7MRDV DMG1LVA MN Macrophage colony-stimulating factor 1 receptor (CSF1R) DMG1LVA MT DTT DMG1LVA MA Antagonist DMG1LVA RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMG1LVA RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DMQI43G DI DMQI43G DMQI43G DN BMS 650032 DMQI43G MI DEJVYAZ DMQI43G MN Cytochrome P450 2A6 (CYP2A6) DMQI43G MT DME DMQI43G MA Metabolism DMQI43G RN Australian Public Assessment Report for asunaprevir. DMQI43G RU https://www.tga.gov.au/sites/default/files/auspar-asunaprevir-151214.pdf DMQI43G DI DMQI43G DMQI43G DN BMS 650032 DMQI43G MI DEPKLMQ DMQI43G MN Cytochrome P450 2B6 (CYP2B6) DMQI43G MT DME DMQI43G MA Metabolism DMQI43G RN Australian Public Assessment Report for asunaprevir. DMQI43G RU https://www.tga.gov.au/sites/default/files/auspar-asunaprevir-151214.pdf DMQI43G DI DMQI43G DMQI43G DN BMS 650032 DMQI43G MI DE5IED8 DMQI43G MN Cytochrome P450 2C9 (CYP2C9) DMQI43G MT DME DMQI43G MA Metabolism DMQI43G RN Australian Public Assessment Report for asunaprevir. DMQI43G RU https://www.tga.gov.au/sites/default/files/auspar-asunaprevir-151214.pdf DMQI43G DI DMQI43G DMQI43G DN BMS 650032 DMQI43G MI DECB0K3 DMQI43G MN Cytochrome P450 2D6 (CYP2D6) DMQI43G MT DME DMQI43G MA Metabolism DMQI43G RN Asunaprevir: a review of preclinical and clinical pharmacokinetics and drug-drug interactions. Clin Pharmacokinet. 2015 Dec;54(12):1205-22. DMQI43G RU https://www.ncbi.nlm.nih.gov/pubmed/?term=26177803 DMQI43G DI DMQI43G DMQI43G DN BMS 650032 DMQI43G MI DE4LYSA DMQI43G MN Cytochrome P450 3A4 (CYP3A4) DMQI43G MT DME DMQI43G MA Metabolism DMQI43G RN Characterization of ADME properties of [(14)C]asunaprevir (BMS-650032) in humans. Xenobiotica. 2016;46(1):52-64. DMQI43G RU https://www.ncbi.nlm.nih.gov/pubmed/?term=26153443 DMQI43G DI DMQI43G DMQI43G DN BMS 650032 DMQI43G MI DEIBDNY DMQI43G MN Cytochrome P450 3A5 (CYP3A5) DMQI43G MT DME DMQI43G MA Metabolism DMQI43G RN Characterization of ADME properties of [(14)C]asunaprevir (BMS-650032) in humans. Xenobiotica. 2016;46(1):52-64. DMQI43G RU https://www.ncbi.nlm.nih.gov/pubmed/?term=26153443 DMQI43G DI DMQI43G DMQI43G DN BMS 650032 DMQI43G MI TT5FNQT DMQI43G MN Human immunodeficiency virus Protease (HIV PR) DMQI43G MT DTT DMQI43G MA Inhibitor DMQI43G RN 2011 Pipeline of Bristol-Myers Squibb. DMQI43G RU http://www.bms.com/pages/default.aspx DMQI43G DI DMQI43G DMQI43G DN BMS 650032 DMQI43G MI DEGTFWK DMQI43G MN Mephenytoin 4-hydroxylase (CYP2C19) DMQI43G MT DME DMQI43G MA Metabolism DMQI43G RN Australian Public Assessment Report for asunaprevir. DMQI43G RU https://www.tga.gov.au/sites/default/files/auspar-asunaprevir-151214.pdf DMQI43G DI DMQI43G DMQI43G DN BMS 650032 DMQI43G MI DTUGYRD DMQI43G MN P-glycoprotein 1 (ABCB1) DMQI43G MT DTP DMQI43G MA Substrate DMQI43G RN KEGG: new perspectives on genomes, pathways, diseases and drugs. Nucleic Acids Res. 2017 Jan 4;45(D1):D353-D361. (dg:DG01665) DMQI43G RU https://www.kegg.jp/dbget-bin/www_bget?dg:DG01665 DMKH4PI DI DMKH4PI DMKH4PI DN BMS 791325 DMKH4PI MI TTMVBWH DMKH4PI MN Hepatitis C virus RNA-directed RNA polymerase (HCV NS5B) DMKH4PI MT DTT DMKH4PI MA Inhibitor DMKH4PI RN 2011 Pipeline of Bristol-Myers Squibb. DMKH4PI RU http://www.bms.com/pages/default.aspx DMDPLEM DI DMDPLEM DMDPLEM DN BMS-184476 DMDPLEM MI TTML2WA DMDPLEM MN Tubulin (TUB) DMDPLEM MT DTT DMDPLEM MA Inhibitor DMDPLEM RN Phase I trial of the novel taxane BMS-184476 administered in combination with carboplatin every 21 days. Br J Cancer. 2004 July 19; 91(2): 213-218. DMDPLEM RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2409820/ DML1CK2 DI DML1CK2 DML1CK2 DN BMS-188797 DML1CK2 MI TTML2WA DML1CK2 MN Tubulin (TUB) DML1CK2 MT DTT DML1CK2 MA Inhibitor DML1CK2 RN Phase I and pharmacokinetic study of BMS-188797, a new taxane analog, administered on a weekly schedule in patients with advanced malignancies. Clin Cancer Res. 2003 Nov 1;9(14):5187-94. DML1CK2 RU https://pubmed.ncbi.nlm.nih.gov/14613998 DMJUV6C DI DMJUV6C DMJUV6C DN BMS-223131 DMJUV6C MI TT1AQ50 DMJUV6C MN Charybdotoxin receptor beta-4 (BKbeta4) DMJUV6C MT DTT DMJUV6C MA Modulator DMJUV6C RN Effect of 4-(5-chloro-2-hydroxyphenyl)-3-(2-hydroxyethyl)-6-(trifluoromethyl)-quinolin-2(1H)-one (BMS-223131), a novel opener of large conductance ... J Pharmacol Exp Ther. 2005 May;313(2):840-7. DMJUV6C RU https://pubmed.ncbi.nlm.nih.gov/15701710 DMQL3VS DI DMQL3VS DMQL3VS DN BMS-275183 DMQL3VS MI TTML2WA DMQL3VS MN Tubulin (TUB) DMQL3VS MT DTT DMQL3VS MA Inhibitor DMQL3VS RN A phase 1 study of BMS-275183, a novel oral analogue of paclitaxel given on a daily schedule to patients with advanced malignancies. Invest New Drugs. 2011 Dec;29(6):1426-31. DMQL3VS RU https://pubmed.ncbi.nlm.nih.gov/20680660 DMGYXFP DI DMGYXFP DMGYXFP DN BMS-582949 DMGYXFP MI TTGFK5X DMGYXFP MN Protein kinase unspecific (PK) DMGYXFP MT DTT DMGYXFP MA Modulator DMGYXFP RN Synthesis and evaluation of carbamoylmethylene linked prodrugs of BMS-582949, a clinical p38alpha inhibitor. Bioorg Med Chem Lett. 2013 May 15;23(10):3028-33. DMGYXFP RU https://pubmed.ncbi.nlm.nih.gov/23578688 DMGYXFP DI DMGYXFP DMGYXFP DN BMS-582949 DMGYXFP MI TTWELHI DMGYXFP MN Stress-activated protein kinase (p38) DMGYXFP MT DTT DMGYXFP MA Inhibitor DMGYXFP RN Synthesis and evaluation of carbamoylmethylene linked prodrugs of BMS-582949, a clinical p38alpha inhibitor. Bioorg Med Chem Lett. 2013 May 15;23(10):3028-33. DMGYXFP RU https://pubmed.ncbi.nlm.nih.gov/23578688 DMDPQV5 DI DMDPQV5 DMDPQV5 DN BMS-599626 DMDPQV5 MI TTGKNB4 DMDPQV5 MN Epidermal growth factor receptor (EGFR) DMDPQV5 MT DTT DMDPQV5 MA Inhibitor DMDPQV5 RN AC480, formerly BMS-599626, a pan Her inhibitor, enhances radiosensitivity and radioresponse of head and neck squamous cell carcinoma cells in vitro and in vivo. Invest New Drugs. 2011 Aug;29(4):554-61. DMDPQV5 RU https://pubmed.ncbi.nlm.nih.gov/20119866 DMDPQV5 DI DMDPQV5 DMDPQV5 DN BMS-599626 DMDPQV5 MI TT6EO5L DMDPQV5 MN Erbb2 tyrosine kinase receptor (HER2) DMDPQV5 MT DTT DMDPQV5 MA Inhibitor DMDPQV5 RN A comparison of physicochemical property profiles of marketed oral drugs and orally bioavailable anti-cancer protein kinase inhibitors in clinical development. Curr Top Med Chem. 2007;7(14):1408-22. DMDPQV5 RU https://pubmed.ncbi.nlm.nih.gov/17692029 DMX302C DI DMX302C DMX302C DN BMS-690514 DMX302C MI TTGKNB4 DMX302C MN Epidermal growth factor receptor (EGFR) DMX302C MT DTT DMX302C MA Inhibitor DMX302C RN Preclinical pharmacokinetics and in vitro metabolism of BMS-690514, a potent inhibitor of EGFR and VEGFR2. J Pharm Sci. 2010 Aug;99(8):3579-93. DMX302C RU https://pubmed.ncbi.nlm.nih.gov/20166197 DMX302C DI DMX302C DMX302C DN BMS-690514 DMX302C MI TTR5TV4 DMX302C MN ERBB2 messenger RNA (HER2 mRNA) DMX302C MT DTT DMX302C MA Inhibitor DMX302C RN Preclinical pharmacokinetics and in vitro metabolism of BMS-690514, a potent inhibitor of EGFR and VEGFR2. J Pharm Sci. 2010 Aug;99(8):3579-93. DMX302C RU https://pubmed.ncbi.nlm.nih.gov/20166197 DMX302C DI DMX302C DMX302C DN BMS-690514 DMX302C MI TTGJCWZ DMX302C MN Fms-like tyrosine kinase 3 (FLT-3) DMX302C MT DTT DMX302C MA Inhibitor DMX302C RN Preclinical pharmacokinetics and in vitro metabolism of BMS-690514, a potent inhibitor of EGFR and VEGFR2. J Pharm Sci. 2010 Aug;99(8):3579-93. DMX302C RU https://pubmed.ncbi.nlm.nih.gov/20166197 DMX302C DI DMX302C DMX302C DN BMS-690514 DMX302C MI TTUTJGQ DMX302C MN Vascular endothelial growth factor receptor 2 (KDR) DMX302C MT DTT DMX302C MA Inhibitor DMX302C RN Preclinical pharmacokinetics and in vitro metabolism of BMS-690514, a potent inhibitor of EGFR and VEGFR2. J Pharm Sci. 2010 Aug;99(8):3579-93. DMX302C RU https://pubmed.ncbi.nlm.nih.gov/20166197 DM51LTG DI DM51LTG DM51LTG DN BMS-708163 DM51LTG MI TT9W8GU DM51LTG MN Gamma-secretase (GS) DM51LTG MT DTT DM51LTG MA Modulator DM51LTG RN Safety and tolerability of the gamma-secretase inhibitor avagacestat in a phase 2 study of mild to moderate Alzheimer disease. Arch Neurol. 2012 Nov;69(11):1430-40. DM51LTG RU https://pubmed.ncbi.nlm.nih.gov/22892585 DMTVGY7 DI DMTVGY7 DMTVGY7 DN BMS-770767 DMTVGY7 MI TTN7BL9 DMTVGY7 MN Corticosteroid 11-beta-dehydrogenase 1 (HSD11B1) DMTVGY7 MT DTT DMTVGY7 MA Modulator DMTVGY7 RN New Therapeutic Strategies for Type 2 Diabetes: Small Molecule Approaches. 2012. Chapter 5. Page(131). DMTVGY7 RU https://books.google.com.hk/books?id=0rmlVGhlJ0IC&pg=PA131&lpg=PA131&dq=RG-7234++New+Therapeutic+Strategies+for+Type+2+Diabetes&source=bl&ots=toqK7w4uiI&sig=sx5iyfQWH2bTCSZmT5aUQiKfPuM&hl=zh-CN&sa=X&ved=0CB0Q6AEwAGoVChMIsZ_k6dDGyAIViLeOCh0oUQpr#v=onepage&q=RG-7234%20%20New%20Therapeutic%20Strategies%20for%20Type%202%20Diabetes&f=false DMKY638 DI DMKY638 DMKY638 DN BMS-813160 DMKY638 MI TTFZYTO DMKY638 MN C-C chemokine receptor type 2 (CCR2) DMKY638 MT DTT DMKY638 MA Modulator DMKY638 RN A dual CCR2/CCR5 chemokine antagonist, BMS-813160. Expert Opin Ther Pat. 2011 Dec;21(12):1919-24. DMKY638 RU https://pubmed.ncbi.nlm.nih.gov/21936726 DMKY638 DI DMKY638 DMKY638 DN BMS-813160 DMKY638 MI TT2CEJG DMKY638 MN C-C chemokine receptor type 5 (CCR5) DMKY638 MT DTT DMKY638 MA Modulator DMKY638 RN A dual CCR2/CCR5 chemokine antagonist, BMS-813160. Expert Opin Ther Pat. 2011 Dec;21(12):1919-24. DMKY638 RU https://pubmed.ncbi.nlm.nih.gov/21936726 DMT8L6P DI DMT8L6P DMT8L6P DN BMS-817399 DMT8L6P MI TTC24WT DMT8L6P MN C-C chemokine receptor type 1 (CCR1) DMT8L6P MT DTT DMT8L6P MA Modulator DMT8L6P RN Discovery of the CCR1 antagonist, BMS-817399, for the treatment of rheumatoid arthritis. J Med Chem. 2014 Sep 25;57(18):7550-64. DMT8L6P RU https://pubmed.ncbi.nlm.nih.gov/25101488 DMF46PD DI DMF46PD DMF46PD DN BMS-911543 DMF46PD MI TTRMX3V DMF46PD MN Janus kinase 2 (JAK-2) DMF46PD MT DTT DMF46PD MA Modulator DMF46PD RN Characterization of BMS-911543, a functionally selective small-molecule inhibitor of JAK2. Leukemia. 2012 Feb;26(2):280-8. DMF46PD RU https://pubmed.ncbi.nlm.nih.gov/22015772 DMN28WK DI DMN28WK DMN28WK DN BMS-919373 DMN28WK MI TTW0CMT DMN28WK MN Voltage-gated potassium channel Kv1.5 (KCNA5) DMN28WK MT DTT DMN28WK MA Inhibitor DMN28WK RN Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800035504) DMN28WK RU http://adisinsight.springer.com/drugs/800035504 DMUTS1W DI DMUTS1W DMUTS1W DN BMS-936557 DMUTS1W MI TTQOVYA DMUTS1W MN C-X-C motif chemokine 10 (CXCL10) DMUTS1W MT DTT DMUTS1W RN Anti-IP-10 antibody (BMS-936557) for ulcerative colitis: a phase II randomised study. Gut. 2014 Mar;63(3):442-50. DMUTS1W RU https://pubmed.ncbi.nlm.nih.gov/23461895 DM7XV4R DI DM7XV4R DM7XV4R DN BMS-954561 DM7XV4R MI TTJSZTB DM7XV4R MN Nicotinic acetylcholine receptor (nAChR) DM7XV4R MT DTT DM7XV4R MA Modulator DM7XV4R RN EP patent application no. 2774991, Drug delivery system for use in the treatment or diagnosis of neurological disorders. DM7XV4R RU http://www.google.com/patents/EP2774991A1?cl=en DMMEAGO DI DMMEAGO DMMEAGO DN BMS-955176 DMMEAGO MI TT5TOX7 DMMEAGO MN Human immunodeficiency virus Maturation (HIV Mat) DMMEAGO MT DTT DMMEAGO MA Inhibitor DMMEAGO RN Clinical pipeline report, company report or official report of Bristol-Myers Squibb. DMMEAGO RU http://news.bms.com/press-release/study-next-generation-investigational-hiv-1-maturation-inhibitor-shows-positive-result DMVJXOH DI DMVJXOH DMVJXOH DN BMS-986012 DMVJXOH MI TTW7KYV DMVJXOH MN Fucosyl GM1 (FucGM1) DMVJXOH MT DTT DMVJXOH MA Inhibitor DMVJXOH RN A Novel, Fully Human Anti-fucosyl-GM1 Antibody Demonstrates Potent In Vitro and In Vivo Antitumor Activity in Preclinical Models of Small Cell Lung Cancer. Clin Cancer Res. 2018 Oct 15;24(20):5178-5189. DMVJXOH RU https://pubmed.ncbi.nlm.nih.gov/30021910 DMHMV6E DI DMHMV6E DMHMV6E DN BMS-986020 DMHMV6E MI TTQ6S1K DMHMV6E MN Lysophosphatidic acid receptor 1 (LPAR1) DMHMV6E MT DTT DMHMV6E MA Antagonist DMHMV6E RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMHMV6E RU http://phrma-docs.phrma.org/files/dmfile/medicines-in-development-drug-list-autoimmune-diseases.pdf DMIZKEC DI DMIZKEC DMIZKEC DN BMS-986036 DMIZKEC MI TTQ916P DMIZKEC MN Fibroblast growth factor-21 (FGF21) DMIZKEC MT DTT DMIZKEC MA Agonist DMIZKEC RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMIZKEC RU http://phrma-docs.phrma.org/files/dmfile/mid-diabetes-drug-list.pdf DMTKDIP DI DMTKDIP DMTKDIP DN BMS-986141 DMTKDIP MI TT3I4WV DMTKDIP MN Prostate apoptosis response-4 (PAWR) DMTKDIP MT DTT DMTKDIP MA Antagonist DMTKDIP RN Protease activated receptor 4 (PAR4) antagonists: Research progress on small molecules in the field of antiplatelet agents. Eur J Med Chem. 2021 Jan 1;209:112893. DMTKDIP RU https://pubmed.ncbi.nlm.nih.gov/33049608 DMZB8AJ DI DMZB8AJ DMZB8AJ DN BMS-986142 DMZB8AJ MI TTGM6VW DMZB8AJ MN Tyrosine-protein kinase BTK (ATK) DMZB8AJ MT DTT DMZB8AJ MA Inhibitor DMZB8AJ RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMZB8AJ RU http://phrma-docs.phrma.org/files/dmfile/medicines-in-development-drug-list-autoimmune-diseases.pdf DM4QHZS DI DM4QHZS DM4QHZS DN BMS-986177 DM4QHZS MI TTDM4ZU DM4QHZS MN Factor XI messenger RNA (F11 mRNA) DM4QHZS MT DTT DM4QHZS MA Inhibitor DM4QHZS RN Discovery methods of coagulation-inhibiting drugs. Expert Opin Drug Discov. 2017 Dec;12(12):1195-1205. DM4QHZS RU https://pubmed.ncbi.nlm.nih.gov/28952381 DM5OU2W DI DM5OU2W DM5OU2W DN BMS-986253 DM5OU2W MI TT3JF7X DM5OU2W MN HUMAN interleukin 8 (IL8) DM5OU2W MT DTT DM5OU2W MA Inhibitor DM5OU2W RN ClinicalTrials.gov (NCT04347226) Anti-Interleukin-8 (Anti-IL-8) for Patients With COVID-19. U.S. National Institutes of Health. DM5OU2W RU https://clinicaltrials.gov/ct2/show/NCT04347226 DM42B0C DI DM42B0C DM42B0C DN BMS-986253 DM42B0C MI TTCTE1G DM42B0C MN Interleukin-8 (IL8) DM42B0C MT DTT DM42B0C MA Inhibitor DM42B0C RN Phase I trial of HuMax-IL8 (BMS-986253), an anti-IL-8 monoclonal antibody, in patients with metastatic or unresectable solid tumors. J Immunother Cancer. 2019 Sep 5;7(1):240. DM42B0C RU https://pubmed.ncbi.nlm.nih.gov/31488216 DMSRVXO DI DMSRVXO DMSRVXO DN BMS-986263 DMSRVXO MI TTPSWQG DMSRVXO MN SERPINH1 messenger RNA (SERPINH1 mRNA) DMSRVXO MT DTT DMSRVXO MA Inhibitor DMSRVXO RN A Fit-for-Purpose Method for the Detection of Human Antibodies to Surface-Exposed Components of BMS-986263, a Lipid Nanoparticle-Based Drug Product Containing a siRNA Drug Substance. AAPS J. 2019 Jul 22;21(5):92. DMSRVXO RU https://pubmed.ncbi.nlm.nih.gov/31332587 DMUM2KA DI DMUM2KA DMUM2KA DN BN82451 DMUM2KA MI TTK0943 DMUM2KA MN Prostaglandin G/H synthase (COX) DMUM2KA MT DTT DMUM2KA MA Inhibitor DMUM2KA RN Emerging drug therapies in Huntington's disease. Expert Opin Emerg Drugs. 2009 Jun;14(2):273-97. DMUM2KA RU https://pubmed.ncbi.nlm.nih.gov/19453283 DMUM2KA DI DMUM2KA DMUM2KA DN BN82451 DMUM2KA MI TTRK8B9 DMUM2KA MN Sodium channel unspecific (NaC) DMUM2KA MT DTT DMUM2KA MA Blocker DMUM2KA RN Emerging drug therapies in Huntington's disease. Expert Opin Emerg Drugs. 2009 Jun;14(2):273-97. DMUM2KA RU https://pubmed.ncbi.nlm.nih.gov/19453283 DMJC8DR DI DMJC8DR DMJC8DR DN BNC-105 DMJC8DR MI TTYFKSZ DMJC8DR MN Tubulin beta (TUBB) DMJC8DR MT DTT DMJC8DR MA Modulator DMJC8DR RN The vascular disrupting agent BNC105 potentiates the efficacy of VEGF and mTOR inhibitors in renal and breast cancer.Cancer Biol Ther.2014;15(11):1552-60. DMJC8DR RU https://www.ncbi.nlm.nih.gov/pubmed/25482941 DMEGDWA DI DMEGDWA DMEGDWA DN BNC-210 DMEGDWA MI TTNJYV2 DMEGDWA MN Gamma-aminobutyric acid receptor (GAR) DMEGDWA MT DTT DMEGDWA MA Modulator DMEGDWA RN 50 years of hurdles and hope in anxiolytic drug discovery. Nat Rev Drug Discov. 2013 Sep;12(9):667-87. DMEGDWA RU https://pubmed.ncbi.nlm.nih.gov/23989795 DMRWG8B DI DMRWG8B DMRWG8B DN BNT321 DMRWG8B MI TTD9I12 DMRWG8B MN Carbohydrate antigen 19-9 (CA 19-9) DMRWG8B MT DTT DMRWG8B MA Inhibitor DMRWG8B RN Clinical pipeline report, company report or official report of BioNTech. DMRWG8B RU https://biontech.de/science/pipeline DM8JQZC DI DM8JQZC DM8JQZC DN BNZ-1 DM8JQZC MI TTJFA35 DM8JQZC MN Interleukin-15 (IL15) DM8JQZC MT DTT DM8JQZC MA Inhibitor DM8JQZC RN Clinical pipeline report, company report or official report of Bioniz Therapeutics. DM8JQZC RU https://bioniz.com/pipeline/bnz-1/ DM8JQZC DI DM8JQZC DM8JQZC DN BNZ-1 DM8JQZC MI TTF89GD DM8JQZC MN Interleukin-2 (IL2) DM8JQZC MT DTT DM8JQZC MA Inhibitor DM8JQZC RN Clinical pipeline report, company report or official report of Bioniz Therapeutics. DM8JQZC RU https://bioniz.com/pipeline/bnz-1/ DM8JQZC DI DM8JQZC DM8JQZC DN BNZ-1 DM8JQZC MI TT0JTFD DM8JQZC MN Interleukin-9 (IL9) DM8JQZC MT DTT DM8JQZC MA Inhibitor DM8JQZC RN Clinical pipeline report, company report or official report of Bioniz Therapeutics. DM8JQZC RU https://bioniz.com/pipeline/bnz-1/ DMZ70GE DI DMZ70GE DMZ70GE DN BOS-228 DMZ70GE MI TTJP4SM DMZ70GE MN Bacterial Penicillin binding protein (Bact PBP) DMZ70GE MT DTT DMZ70GE MA Inhibitor DMZ70GE RN Clinical pipeline report, company report or official report of Boston Pharmaceuticals. DMZ70GE RU https://www.bostonpharmaceuticals.com/infectious-disease DMKDGI8 DI DMKDGI8 DMKDGI8 DN BP-100-1-01 DMKDGI8 MI TTEYRJ9 DMKDGI8 MN GRB2 messenger RNA (GRB2 mRNA) DMKDGI8 MT DTT DMKDGI8 MA Modulator DMKDGI8 RN ClinicalTrials.gov (NCT01159028) Clinical Trial of BP1001 (L-Grb-2 Antisense Oligonucleotide) in CML, AML, ALL & MDS. U.S. National Institutes of Health. DMKDGI8 RU https://clinicaltrials.gov/ct2/show/NCT01159028 DMWVPO0 DI DMWVPO0 DMWVPO0 DN BPN14770 DMWVPO0 MI TTSKMI8 DMWVPO0 MN Phosphodiesterase 4D (PDE4D) DMWVPO0 MT DTT DMWVPO0 MA Inhibitor DMWVPO0 RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMWVPO0 RU http://phrma-docs.phrma.org/files/dmfile/MID_Neurological-Disorders-Drug-List_2018.pdf DMDYZRS DI DMDYZRS DMDYZRS DN BPS-804 DMDYZRS MI TTYRO4F DMDYZRS MN Sclerostin (SOST) DMDYZRS MT DTT DMDYZRS RN WO patent application no. 2010,1001,79, Self-forming gel system for sustained drug delivery. DMDYZRS RU http://worldwide.espacenet.com/publicationDetails/biblio?DB=worldwide.espacenet.com&II=0&ND=3&adjacent=true&locale=en_EP&FT=D&date=20100910&CC=WO&NR=2010100179A2&KC=A2 DM0MO8I DI DM0MO8I DM0MO8I DN BQ-123 DM0MO8I MI TTKRD0G DM0MO8I MN Endothelin A receptor (EDNRA) DM0MO8I MT DTT DM0MO8I MA Antagonist DM0MO8I RN Endothelin in heart failure: a promising therapeutic target Heart. 1997 Feb;77(2):93-4. DM0MO8I RU https://pubmed.ncbi.nlm.nih.gov/9068384 DM0MO8I DI DM0MO8I DM0MO8I DN BQ-123 DM0MO8I MI DTFI42L DM0MO8I MN Multidrug resistance-associated protein 2 (ABCC2) DM0MO8I MT DTP DM0MO8I MA Substrate DM0MO8I RN Human intestinal transporter database: QSAR modeling and virtual profiling of drug uptake, efflux and interactions. Pharm Res. 2013 Apr;30(4):996-1007. DM0MO8I RU https://doi.org/10.1007/s11095-012-0935-x DM0MO8I DI DM0MO8I DM0MO8I DN BQ-123 DM0MO8I MI DTE2B1D DM0MO8I MN Organic anion transporting polypeptide 1A2 (SLCO1A2) DM0MO8I MT DTP DM0MO8I MA Substrate DM0MO8I RN Organic anion-transporting polypeptide B (OATP-B) and its functional comparison with three other OATPs of human liver. Gastroenterology. 2001 Feb;120(2):525-33. DM0MO8I RU http://www.ncbi.nlm.nih.gov/pubmed/11159893 DM0MO8I DI DM0MO8I DM0MO8I DN BQ-123 DM0MO8I MI DT3D8F0 DM0MO8I MN Organic anion transporting polypeptide 1B1 (SLCO1B1) DM0MO8I MT DTP DM0MO8I MA Substrate DM0MO8I RN Organic anion transporting polypeptide 1B1: a genetically polymorphic transporter of major importance for hepatic drug uptake. Pharmacol Rev. 2011 Mar;63(1):157-81. DM0MO8I RU http://www.ncbi.nlm.nih.gov/pubmed/21245207 DM0MO8I DI DM0MO8I DM0MO8I DN BQ-123 DM0MO8I MI DT9C1TS DM0MO8I MN Organic anion transporting polypeptide 1B3 (SLCO1B3) DM0MO8I MT DTP DM0MO8I MA Substrate DM0MO8I RN Organic anion-transporting polypeptide B (OATP-B) and its functional comparison with three other OATPs of human liver. Gastroenterology. 2001 Feb;120(2):525-33. DM0MO8I RU http://www.ncbi.nlm.nih.gov/pubmed/11159893 DMNFKVW DI DMNFKVW DMNFKVW DN BR-4628 DMNFKVW MI TT26PHO DMNFKVW MN Mineralocorticoid receptor (MR) DMNFKVW MT DTT DMNFKVW MA Antagonist DMNFKVW RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 626). DMNFKVW RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=626 DM3TRF7 DI DM3TRF7 DM3TRF7 DN Brasofensine DM3TRF7 MI TT3ROYC DM3TRF7 MN Serotonin transporter (SERT) DM3TRF7 MT DTT DM3TRF7 MA Modulator DM3TRF7 RN Brasofensine NeuroSearch. Curr Opin Investig Drugs. 2000 Dec;1(4):504-7. DM3TRF7 RU https://pubmed.ncbi.nlm.nih.gov/11249705 DMKGM42 DI DMKGM42 DMKGM42 DN BREQUINAR DMKGM42 MI TTLVP78 DMKGM42 MN Dihydroorotate dehydrogenase (DHODH) DMKGM42 MT DTT DMKGM42 MA Modulator DMKGM42 RN DOI: 10.1203/00006450-198807000-00137 DMKGM42 RU http://www.nature.com/pr/journal/v24/n1/abs/pr1988506a.html DMXI9BP DI DMXI9BP DMXI9BP DN Brilacidin DMXI9BP MI TTXT4D5 DMXI9BP MN Bacterial Cell membrane (Bact CM) DMXI9BP MT DTT DMXI9BP MA Enhancer DMXI9BP RN Comparative mechanistic studies of brilacidin, daptomycin, and the antimicrobial peptide LL16. Antimicrob Agents Chemother. 2014 Sep;58(9):5136-45. DMXI9BP RU https://pubmed.ncbi.nlm.nih.gov/24936592 DMLD80M DI DMLD80M DMLD80M DN Brivoligide DMLD80M MI TTE8LGD DMLD80M MN EGR1 messenger RNA (EGR1 mRNA) DMLD80M MT DTT DMLD80M MA Inhibitor DMLD80M RN ClinicalTrials.gov (NCT04104919) Study to Evaluate a Preop Dose of Brivoligide Injection for Pain After Mastectomy in Patients With High PCS Scores. U.S. National Institutes of Health. DMLD80M RU https://clinicaltrials.gov/ct2/show/NCT04104919 DMLFGHX DI DMLFGHX DMLFGHX DN BRL 35135 DMLFGHX MI TTR6W5O DMLFGHX MN Adrenergic receptor beta-1 (ADRB1) DMLFGHX MT DTT DMLFGHX MA Agonist DMLFGHX RN Clinical pharmacology of beta 3-adrenoceptors. Br J Clin Pharmacol. 1996 Sep;42(3):291-300. DMLFGHX RU https://pubmed.ncbi.nlm.nih.gov/8877018 DMUI5PA DI DMUI5PA DMUI5PA DN Brostallicin DMUI5PA MI TTOVXHF DMUI5PA MN Human Deoxyribonucleic acid minor groove (hDNA min) DMUI5PA MT DTT DMUI5PA MA Inhibitor DMUI5PA RN Brostallicin (PNU-166196), a new minor groove DNA binder: preclinical and clinical activity. Expert Opin Investig Drugs. 2009 Dec;18(12):1939-46. DMUI5PA RU https://pubmed.ncbi.nlm.nih.gov/19938904 DM1ZOCK DI DM1ZOCK DM1ZOCK DN Bryostatin-1 DM1ZOCK MI TTBZ7OD DM1ZOCK MN Protein kinase C epsilon (PRKCE) DM1ZOCK MT DTT DM1ZOCK MA Activator DM1ZOCK RN Protein kinase epsilon dampens the secretory response of model intestinal epithelia during ischemia. Surgery. 2001 Aug;130(2):310-8. DM1ZOCK RU https://pubmed.ncbi.nlm.nih.gov/11490365 DM2LZIY DI DM2LZIY DM2LZIY DN BT-061 DM2LZIY MI TTN2JFW DM2LZIY MN T-cell surface glycoprotein CD4 (CD4) DM2LZIY MT DTT DM2LZIY RN Tregalizumab (BT-061) increases regulatory T cell function. Boosting regulatory T-cell function with the humanized CD4-specific humanized monoclonal antibody Tregalizumab (BT-061). Immunol Cell Biol.2015 Apr;93(4):321-2. DM2LZIY RU https://pubmed.ncbi.nlm.nih.gov/25666094 DMYO185 DI DMYO185 DMYO185 DN BT-062 DMYO185 MI TTYDSVG DMYO185 MN Syndecan-1 (SDC1) DMYO185 MT DTT DMYO185 RN The monoclonal antibody nBT062 conjugated to cytotoxic Maytansinoids has selective cytotoxicity against CD138-positive multiple myeloma cells in vitro and in vivo. Clin Cancer Res. 2009 Jun 15;15(12):4028-37. DMYO185 RU https://pubmed.ncbi.nlm.nih.gov/19509164 DMDWP0U DI DMDWP0U DMDWP0U DN BTA-798 DMDWP0U MI TT8R3VP DMDWP0U MN Rhinovirus Capsid protein (HRV VP) DMDWP0U MT DTT DMDWP0U MA Inhibitor DMDWP0U RN Combating enterovirus replication: state-of-the-art on antiviral research. Biochem Pharmacol. 2012 Jan 15;83(2):185-92. DMDWP0U RU https://pubmed.ncbi.nlm.nih.gov/21889497 DMS6ZA0 DI DMS6ZA0 DMS6ZA0 DN BTD-001 DMS6ZA0 MI TTCI43M DMS6ZA0 MN GABA(A) receptor (GABAR) DMS6ZA0 MT DTT DMS6ZA0 MA Antagonist DMS6ZA0 RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMS6ZA0 RU http://phrma-docs.phrma.org/files/dmfile/MID_Neurological-Disorders-Drug-List_2018.pdf DMY5IX4 DI DMY5IX4 DMY5IX4 DN BTL-TML-001 DMY5IX4 MI TTL3N71 DMY5IX4 MN Virus Replication (Viru Repli) DMY5IX4 MT DTT DMY5IX4 MA Inhibitor DMY5IX4 RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMY5IX4 RU http://phrma-docs.phrma.org/files/dmfile/MID_Skin_Diseases_2018_9_FINAL.pdf DMA9238 DI DMA9238 DMA9238 DN BTRX-246040 DMA9238 MI TTNT7K8 DMA9238 MN Nociceptin receptor (OPRL1) DMA9238 MT DTT DMA9238 MA Antagonist DMA9238 RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMA9238 RU http://phrma-docs.phrma.org/files/dmfile/MID_Mental-Illness-2017-Drug-List_Final.pdf DMWPDUZ DI DMWPDUZ DMWPDUZ DN BTRX-335140 DMWPDUZ MI TTQW87Y DMWPDUZ MN Opioid receptor kappa (OPRK1) DMWPDUZ MT DTT DMWPDUZ MA Antagonist DMWPDUZ RN Clinical pipeline report, company report or official report of BlackThorn Therapeutics. DMWPDUZ RU https://www.blackthornrx.com/btrx-335140-kappa-opioid-receptor-antagonist/ DMIEPJG DI DMIEPJG DMIEPJG DN BTT-1023 DMIEPJG MI TT7HC21 DMIEPJG MN Membrane copper amine oxidase (AOC3) DMIEPJG MT DTT DMIEPJG RN Preclinical evaluation of a radioiodinated fully human antibody for in vivo imaging of vascular adhesion protein-1-positive vasculature in inflammation. J Nucl Med. 2013 Aug;54(8):1315-9. DMIEPJG RU https://pubmed.ncbi.nlm.nih.gov/23847292 DMZC4V0 DI DMZC4V0 DMZC4V0 DN Buproprion+zonisamide DMZC4V0 MI TTTQR47 DMZC4V0 MN Solute carrier family 22 member 8 (SLC22A8) DMZC4V0 MT DTT DMZC4V0 MA Blocker DMZC4V0 RN Anti-obesity drugs. Expert Opin Pharmacother. 2008 Jun;9(8):1339-50. DMZC4V0 RU https://pubmed.ncbi.nlm.nih.gov/18473708 DMNB4XK DI DMNB4XK DMNB4XK DN BVD-523 DMNB4XK MI TTKPV6O DMNB4XK MN Ephrin type-B receptor 2 (EPHB2) DMNB4XK MT DTT DMNB4XK MA Inhibitor DMNB4XK RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMNB4XK RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DMNB4XK DI DMNB4XK DMNB4XK DN BVD-523 DMNB4XK MI TT1MG9E DMNB4XK MN Extracellular signal-regulated kinase 1 (ERK1) DMNB4XK MT DTT DMNB4XK MA Modulator DMNB4XK RN DOI: 10.1158/1538-7445.AM2015-4693 DMNB4XK RU http://cancerres.aacrjournals.org/content/75/15_Supplement/4693?cited-by=yes&legid=canres;75/15_Supplement/4693 DMNB4XK DI DMNB4XK DMNB4XK DN BVD-523 DMNB4XK MI TT4TQBX DMNB4XK MN Extracellular signal-regulated kinase 2 (ERK2) DMNB4XK MT DTT DMNB4XK MA Modulator DMNB4XK RN DOI: 10.1158/1538-7445.AM2015-4693 DMNB4XK RU http://cancerres.aacrjournals.org/content/75/15_Supplement/4693?cited-by=yes&legid=canres;75/15_Supplement/4693 DM8CWL0 DI DM8CWL0 DM8CWL0 DN BVT.28949 DM8CWL0 MI TTJQOD7 DM8CWL0 MN 5-HT 2A receptor (HTR2A) DM8CWL0 MT DTT DM8CWL0 MA Antagonist DM8CWL0 RN Novel ocular antihypertensive compounds in clinical trials. Clin Ophthalmol. 2011; 5: 667-677. DM8CWL0 RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3104796/ DMD8GNB DI DMD8GNB DMD8GNB DN BXT-51072 DMD8GNB MI TTF10I9 DMD8GNB MN Nitric-oxide synthase inducible (NOS2) DMD8GNB MT DTT DMD8GNB MA Modulator DMD8GNB RN Shear stress induces iNOS expression in cultured smooth muscle cells: role of oxidative stress. Am J Physiol Cell Physiol. 2000 Dec;279(6):C1880-8. DMD8GNB RU https://pubmed.ncbi.nlm.nih.gov/11078703 DMTRONK DI DMTRONK DMTRONK DN BZL-101 DMTRONK MI TT34ECM DMTRONK MN Cell cycle (CC) DMTRONK MT DTT DMTRONK MA Inhibitor DMTRONK RN BZL101, a phytochemical extract from the Scutellaria barbata plant, disrupts proliferation of human breast and prostate cancer cells through distinct mechanisms dependent on the cancer cell phenotype. Cancer Biol Ther. 2010 Aug 15;10(4):397-405. DMTRONK RU https://www.ncbi.nlm.nih.gov/pubmed/20574166 DMGE058 DI DMGE058 DMGE058 DN Cabiralizumab DMGE058 MI TTNYZG2 DMGE058 MN Granulocyte-macrophage colony-stimulating factor (CSF2) DMGE058 MT DTT DMGE058 MA Antagonist DMGE058 RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMGE058 RU http://phrma-docs.phrma.org/files/dmfile/MID_Immuno-Oncology-2017_Drug-List1.pdf DMGE058 DI DMGE058 DMGE058 DN Cabiralizumab DMGE058 MI TT7MRDV DMGE058 MN Macrophage colony-stimulating factor 1 receptor (CSF1R) DMGE058 MT DTT DMGE058 MA Antagonist DMGE058 RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMGE058 RU http://phrma-docs.phrma.org/files/dmfile/MID_Immuno-Oncology-2017_Drug-List1.pdf DMGXCY9 DI DMGXCY9 DMGXCY9 DN Calcium phosphate DMGXCY9 MI DT42EWA DMGXCY9 MN Sodium-dependent phosphate transport protein 2A (SLC34A1) DMGXCY9 MT DTP DMGXCY9 MA Substrate DMGXCY9 RN Phosphate transporters and their function. Annu Rev Physiol. 2013;75:535-50. DMGXCY9 RU http://www.ncbi.nlm.nih.gov/pubmed/23398154 DMDV8MK DI DMDV8MK DMDV8MK DN CALDARET HYDRATE DMDV8MK MI TT619TC DMDV8MK MN Sodium/calcium exchanger (SLC) DMDV8MK MT DTT DMDV8MK MA Modulator DMDV8MK RN Caldaret, an intracellular Ca2+ handling modulator, limits infarct size of reperfused canine heart. J Pharmacol Sci. 2007 Feb;103(2):222-33. DMDV8MK RU https://pubmed.ncbi.nlm.nih.gov/17299242 DMAKSMX DI DMAKSMX DMAKSMX DN Camicinal DMAKSMX MI TT953CX DMAKSMX MN Motilin receptor (MLNR) DMAKSMX MT DTT DMAKSMX MA Modulator DMAKSMX RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 297). DMAKSMX RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=297 DMQ7UL8 DI DMQ7UL8 DMQ7UL8 DN Camostat DMQ7UL8 MI DTT79CX DMQ7UL8 MN Organic cation transporter 1 (SLC22A1) DMQ7UL8 MT DTP DMQ7UL8 MA Substrate DMQ7UL8 RN Identification of novel substrates and structure-activity relationship of cellular uptake mediated by human organic cation transporters 1 and 2. J Med Chem. 2013 Sep 26;56(18):7232-42. DMQ7UL8 RU http://www.ncbi.nlm.nih.gov/pubmed/23984907 DMQ7UL8 DI DMQ7UL8 DMQ7UL8 DN Camostat DMQ7UL8 MI TTEMV5X DMQ7UL8 MN Serine protease unspecific (SP) DMQ7UL8 MT DTT DMQ7UL8 MA Inhibitor DMQ7UL8 RN Camostat mesilate inhibits prostasin activity and reduces blood pressure and renal injury in salt-sensitive hypertension. J Hypertens. 2009 Jan;27(1):181-9. DMQ7UL8 RU https://pubmed.ncbi.nlm.nih.gov/19145783 DMEZLFT DI DMEZLFT DMEZLFT DN Camsirubicin DMEZLFT MI TTCGY2K DMEZLFT MN DNA topoisomerase II alpha (TOP2A) DMEZLFT MT DTT DMEZLFT MA Inhibitor DMEZLFT RN Clinical pipeline report, company report or official report of Monopar Therapeutics. DMEZLFT RU https://www.monopartx.com/pipeline/Camsirubicin DMEYIVW DI DMEYIVW DMEYIVW DN CAP1-6D DMEYIVW MI TTY6DTE DMEYIVW MN Carcinoembryonic antigen CEA (CD66e) DMEYIVW MT DTT DMEYIVW MA Modulator DMEYIVW RN Identification of an enhancer agonist cytotoxic T lymphocyte peptide from human carcinoembryonic antigen. Cancer Res. 1997 Oct 15;57(20):4570-7. DMEYIVW RU https://pubmed.ncbi.nlm.nih.gov/9377571 DMJKLHU DI DMJKLHU DMJKLHU DN CAP-7.1 DMJKLHU MI TT0IHXV DMJKLHU MN DNA topoisomerase II (TOP2) DMJKLHU MT DTT DMJKLHU MA Modulator DMJKLHU RN Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41. DMJKLHU RU https://www.ncbi.nlm.nih.gov/pubmed/15950434 DMYWO62 DI DMYWO62 DMYWO62 DN Capadenoson DMYWO62 MI TTK25J1 DMYWO62 MN Adenosine A1 receptor (ADORA1) DMYWO62 MT DTT DMYWO62 MA Agonist DMYWO62 RN A1 adenosine receptor agonists and their potential therapeutic applications. Expert Opin Investig Drugs. 2008 Dec;17(12):1901-10. DMYWO62 RU https://pubmed.ncbi.nlm.nih.gov/19012505 DMY4OMS DI DMY4OMS DMY4OMS DN Carabersat DMY4OMS MI TTSB7ZR DMY4OMS MN Trigeminal ganglion stimulation-induced response (TGSR) DMY4OMS MT DTT DMY4OMS MA Modulator DMY4OMS RN Tonabersat (SB-220453) a novel benzopyran with anticonvulsant properties attenuates trigeminal nerve-induced neurovascular reflexes. Br J Pharmacol. 2001 April; 132(7): 1549-1557. DMY4OMS RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1572685/ DMN5JCX DI DMN5JCX DMN5JCX DN Carboxyamidotriazole orotate DMN5JCX MI TTF89GD DMN5JCX MN Interleukin-2 (IL2) DMN5JCX MT DTT DMN5JCX MA Inhibitor DMN5JCX RN J Clin Oncol 32:5s, 2014 (suppl; abstr 2071). DMN5JCX RU http://meetinglibrary.asco.org/content/132006-144 DM7ADGX DI DM7ADGX DM7ADGX DN Carfentanil DM7ADGX MI DE2PJF5 DM7ADGX MN Acid cholesteryl ester hydrolase (LIPA) DM7ADGX MT DME DM7ADGX MA Metabolism DM7ADGX RN Metabolism of carfentanil, an ultra-potent opioid, in human liver microsomes and human hepatocytes by high-resolution mass spectrometry. AAPS J. 2016 Nov;18(6):1489-1499. DM7ADGX RU https://www.ncbi.nlm.nih.gov/pubmed/?term=27495118 DM7ADGX DI DM7ADGX DM7ADGX DN Carfentanil DM7ADGX MI DE4LYSA DM7ADGX MN Cytochrome P450 3A4 (CYP3A4) DM7ADGX MT DME DM7ADGX MA Metabolism DM7ADGX RN Metabolism of carfentanil, an ultra-potent opioid, in human liver microsomes and human hepatocytes by high-resolution mass spectrometry. AAPS J. 2016 Nov;18(6):1489-1499. DM7ADGX RU https://www.ncbi.nlm.nih.gov/pubmed/?term=27495118 DM7ADGX DI DM7ADGX DM7ADGX DN Carfentanil DM7ADGX MI TT27RFC DM7ADGX MN Opioid receptor delta (OPRD1) DM7ADGX MT DTT DM7ADGX MA Agonist DM7ADGX RN Wax PM, Becker CE, Curry SC: Unexpected gas casualties in Moscow: a medical toxicology perspective. Ann Emerg Med. 2003 May;41(5):700-5. DM7ADGX RU https://pubmed.ncbi.nlm.nih.gov/12712038 DM7ADGX DI DM7ADGX DM7ADGX DN Carfentanil DM7ADGX MI TTQW87Y DM7ADGX MN Opioid receptor kappa (OPRK1) DM7ADGX MT DTT DM7ADGX MA Agonist DM7ADGX RN Wax PM, Becker CE, Curry SC: Unexpected gas casualties in Moscow: a medical toxicology perspective. Ann Emerg Med. 2003 May;41(5):700-5. DM7ADGX RU https://pubmed.ncbi.nlm.nih.gov/12712038 DM7ADGX DI DM7ADGX DM7ADGX DN Carfentanil DM7ADGX MI TTKWM86 DM7ADGX MN Opioid receptor mu (MOP) DM7ADGX MT DTT DM7ADGX MA Agonist DM7ADGX RN Wax PM, Becker CE, Curry SC: Unexpected gas casualties in Moscow: a medical toxicology perspective. Ann Emerg Med. 2003 May;41(5):700-5. DM7ADGX RU https://pubmed.ncbi.nlm.nih.gov/12712038 DMAUN15 DI DMAUN15 DMAUN15 DN Carlumab DMAUN15 MI TTNAY0P DMAUN15 MN Monocyte chemotactic and activating factor (CCL2) DMAUN15 MT DTT DMAUN15 RN Carlumab, an anti-C-C chemokine ligand 2 monoclonal antibody, in combination with four chemotherapy regimens for the treatment of patients with solid tumors: an open-label, multicenter phase 1b study. Target Oncol. 2015 Mar;10(1):111-23. DMAUN15 RU https://pubmed.ncbi.nlm.nih.gov/24928772 DMN6TKI DI DMN6TKI DMN6TKI DN Carmoterol DMN6TKI MI TT2CJVK DMN6TKI MN Adrenergic receptor beta-2 (ADRB2) DMN6TKI MT DTT DMN6TKI MA Agonist DMN6TKI RN Emerging drugs in chronic obstructive pulmonary disease. Expert Opin Emerg Drugs. 2009 Mar;14(1):181-94. DMN6TKI RU https://pubmed.ncbi.nlm.nih.gov/19265487 DMTBFXW DI DMTBFXW DMTBFXW DN CART 19 DMTBFXW MI TTW640A DMTBFXW MN B-lymphocyte surface antigen B4 (CD19) DMTBFXW MT DTT DMTBFXW MA CAR-T-Cell-Therapy DMTBFXW RN ClinicalTrials.gov (NCT02935543) CART19 in Adult Patients With Minimal Residual Disease During Upfront Treatment for ALL DMTBFXW RU https://clinicaltrials.gov/ct2/show/NCT02935543 DM28A5D DI DM28A5D DM28A5D DN CAR-T cells targeting CD19 DM28A5D MI TTW640A DM28A5D MN B-lymphocyte surface antigen B4 (CD19) DM28A5D MT DTT DM28A5D MA CAR-T-Cell-Therapy DM28A5D RN ClinicalTrials.gov (NCT03196830) CAR-T for R/R B-NHL DM28A5D RU https://clinicaltrials.gov/ct2/show/NCT03196830 DM3RU0A DI DM3RU0A DM3RU0A DN CAR-T cells targeting CD20 DM3RU0A MI TTUE541 DM3RU0A MN Leukocyte surface antigen Leu-16 (CD20) DM3RU0A MT DTT DM3RU0A MA CAR-T-Cell-Therapy DM3RU0A RN ClinicalTrials.gov (NCT03196830) CAR-T for R/R B-NHL DM3RU0A RU https://clinicaltrials.gov/ct2/show/NCT03196830 DM6XN4C DI DM6XN4C DM6XN4C DN CAR-T cells targeting CD22 DM6XN4C MI TTM6QSK DM6XN4C MN B-cell receptor CD22 (CD22) DM6XN4C MT DTT DM6XN4C MA CAR-T-Cell-Therapy DM6XN4C RN ClinicalTrials.gov (NCT03196830) CAR-T for R/R B-NHL DM6XN4C RU https://clinicaltrials.gov/ct2/show/NCT03196830 DML0KWM DI DML0KWM DML0KWM DN CAR-T cells targeting CD30 DML0KWM MI TT2GM5R DML0KWM MN Lymphocyte activation antigen CD30 (TNFRSF8) DML0KWM MT DTT DML0KWM MA CAR-T-Cell-Therapy DML0KWM RN ClinicalTrials.gov (NCT03196830) CAR-T for R/R B-NHL DML0KWM RU https://clinicaltrials.gov/ct2/show/NCT03196830 DMHQKN6 DI DMHQKN6 DMHQKN6 DN CART-19 DMHQKN6 MI TTW640A DMHQKN6 MN B-lymphocyte surface antigen B4 (CD19) DMHQKN6 MT DTT DMHQKN6 MA CAR-T-Cell-Therapy DMHQKN6 RN ClinicalTrials.gov (NCT01029366) CART19 to Treat B-Cell Leukemia or Lymphoma That Are Resistant or Refractory to Chemotherapy DMHQKN6 RU https://clinicaltrials.gov/ct2/show/NCT01029366 DMZUV7T DI DMZUV7T DMZUV7T DN CART-19 cells DMZUV7T MI TTW640A DMZUV7T MN B-lymphocyte surface antigen B4 (CD19) DMZUV7T MT DTT DMZUV7T MA CAR-T-Cell-Therapy DMZUV7T RN ClinicalTrials.gov (NCT01551043) Allo CART-19 Protocol DMZUV7T RU https://clinicaltrials.gov/ct2/show/NCT01551043 DMQBP7R DI DMQBP7R DMQBP7R DN CAT 1004 DMQBP7R MI TTUIZKC DMQBP7R MN DNA-binding factor KBF1 (p105) DMQBP7R MT DTT DMQBP7R MA Inhibitor DMQBP7R RN Clinical pipeline report, company report or official report of Catabasis Pharmaceuticals Inc. DMQBP7R RU http://www.catabasis.com/clinical-trials-cat-1004-movedmd.php DMQBP7R DI DMQBP7R DMQBP7R DN CAT 1004 DMQBP7R MI TTSXVID DMQBP7R MN Nuclear factor NF-kappa-B (NFKB) DMQBP7R MT DTT DMQBP7R MA Inhibitor DMQBP7R RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMQBP7R RU http://phrma-docs.phrma.org/sites/default/files/pdf/medicines-in-development-drug-list-rare-diseases.pdf DM2IFYZ DI DM2IFYZ DM2IFYZ DN CB-10-01 DM2IFYZ MI TTUJFD0 DM2IFYZ MN Telomerase reverse transcriptase (TERT) DM2IFYZ MT DTT DM2IFYZ RN Telomerase immunity from bench to bedside: round one. J Transl Med. 2007 Feb 26;5:12. DM2IFYZ RU https://pubmed.ncbi.nlm.nih.gov/17324292 DM094UH DI DM094UH DM094UH DN CB-839 DM094UH MI TTCW0KX DM094UH MN Glutaminase (GLS) DM094UH MT DTT DM094UH MA Modulator DM094UH RN Antitumor activity of the glutaminase inhibitor CB-839 in triple-negative breast cancer. Mol Cancer Ther. 2014 Apr;13(4):890-901. DM094UH RU https://pubmed.ncbi.nlm.nih.gov/24523301 DMK4FRU DI DMK4FRU DMK4FRU DN CBLB-502 DMK4FRU MI TTCXP8J DMK4FRU MN Toll-like receptor 5 (TLR5) DMK4FRU MT DTT DMK4FRU MA Agonist DMK4FRU RN Recombinant TLR5 agonist CBLB502 promotes NK cell-mediated anti-CMV immunity in mice. PLoS One. 2014 May 30;9(5):e96165. DMK4FRU RU https://pubmed.ncbi.nlm.nih.gov/24879439 DMSBNTZ DI DMSBNTZ DMSBNTZ DN CBX-129801 DMSBNTZ MI TTKF4WV DMSBNTZ MN Connecting peptide (C-peptide) DMSBNTZ MT DTT DMSBNTZ MA Modulator DMSBNTZ RN ClinicalTrials.gov (NCT01681290) Safety and Efficacy of CBX129801 in Patients With Type 1 Diabetes. U.S. National Institutes of Health. DMSBNTZ RU https://clinicaltrials.gov/ct2/show/NCT01681290 DMQ874W DI DMQ874W DMQ874W DN CC-1088 DMQ874W MI TTZ97H5 DMQ874W MN Phosphodiesterase 4A (PDE4A) DMQ874W MT DTT DMQ874W MA Inhibitor DMQ874W RN Thalidomide analogs and PDE4 inhibition. Bioorg Med Chem Lett. 1998 Oct 6;8(19):2669-74. DMQ874W RU https://pubmed.ncbi.nlm.nih.gov/9873600 DMQ874W DI DMQ874W DMQ874W DN CC-1088 DMQ874W MI TTVIAT9 DMQ874W MN Phosphodiesterase 4B (PDE4B) DMQ874W MT DTT DMQ874W MA Inhibitor DMQ874W RN Thalidomide analogs and PDE4 inhibition. Bioorg Med Chem Lett. 1998 Oct 6;8(19):2669-74. DMQ874W RU https://pubmed.ncbi.nlm.nih.gov/9873600 DMQ874W DI DMQ874W DMQ874W DN CC-1088 DMQ874W MI TTSKMI8 DMQ874W MN Phosphodiesterase 4D (PDE4D) DMQ874W MT DTT DMQ874W MA Inhibitor DMQ874W RN Thalidomide analogs and PDE4 inhibition. Bioorg Med Chem Lett. 1998 Oct 6;8(19):2669-74. DMQ874W RU https://pubmed.ncbi.nlm.nih.gov/9873600 DMNE7L3 DI DMNE7L3 DMNE7L3 DN CC-220 DMNE7L3 MI TTDKGTC DMNE7L3 MN Protein cereblon (CRBN) DMNE7L3 MT DTT DMNE7L3 MA Inhibitor DMNE7L3 RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMNE7L3 RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DMJR9H0 DI DMJR9H0 DMJR9H0 DN CC-292 DMJR9H0 MI TTGM6VW DMJR9H0 MN Tyrosine-protein kinase BTK (ATK) DMJR9H0 MT DTT DMJR9H0 MA Modulator DMJR9H0 RN Inhibition of Btk with CC-292 provides early pharmacodynamic assessment of activity in mice and humans. J Pharmacol Exp Ther. 2013 Aug;346(2):219-28. DMJR9H0 RU https://pubmed.ncbi.nlm.nih.gov/23709115 DMPMO6G DI DMPMO6G DMPMO6G DN CC-401 DMPMO6G MI TTR2TXZ DMPMO6G MN Jun N terminal kinase (JNK) DMPMO6G MT DTT DMPMO6G MA Modulator DMPMO6G RN Signal integration by JNK and p38 MAPK pathways in cancer development.Nat Rev Cancer.2009 Aug;9(8):537-49. DMPMO6G RU https://www.ncbi.nlm.nih.gov/pubmed/19629069 DM0EDHJ DI DM0EDHJ DM0EDHJ DN CC-90011 DM0EDHJ MI TTNR0UQ DM0EDHJ MN Lysine-specific histone demethylase 1 (LSD) DM0EDHJ MT DTT DM0EDHJ MA Inhibitor DM0EDHJ RN Discovery of CC-90011: A Potent and Selective Reversible Inhibitor of Lysine Specific Demethylase 1 (LSD1). J Med Chem. 2020 Dec 10;63(23):14522-14529. DM0EDHJ RU https://pubmed.ncbi.nlm.nih.gov/33034194 DMHVEGJ DI DMHVEGJ DMHVEGJ DN CC-930 DMHVEGJ MI TTR2TXZ DMHVEGJ MN Jun N terminal kinase (JNK) DMHVEGJ MT DTT DMHVEGJ MA Modulator DMHVEGJ RN In vitro metabolism of a novel JNK inhibitor tanzisertib: interspecies differences in oxido-reduction and characterization of enzymes involved in metabolism. Xenobiotica. 2015;45(6):465-80. DMHVEGJ RU https://pubmed.ncbi.nlm.nih.gov/25475995 DMJ9XCO DI DMJ9XCO DMJ9XCO DN CCX-140 DMJ9XCO MI TTFZYTO DMJ9XCO MN C-C chemokine receptor type 2 (CCR2) DMJ9XCO MT DTT DMJ9XCO MA Antagonist DMJ9XCO RN Present and future in the treatment of diabetic kidney disease. J Diabetes Res. 2015;2015:801348. DMJ9XCO RU https://pubmed.ncbi.nlm.nih.gov/25945357 DMSHV9C DI DMSHV9C DMSHV9C DN CCX-354 DMSHV9C MI TTC24WT DMSHV9C MN C-C chemokine receptor type 1 (CCR1) DMSHV9C MT DTT DMSHV9C MA Antagonist DMSHV9C RN Chemokine receptor CCR1 antagonist CCX354-C treatment for rheumatoid arthritis: CARAT-2, a randomised, placebo controlled clinical trial. Ann Rheum Dis. 2013 Mar;72(3):337-44. DMSHV9C RU https://pubmed.ncbi.nlm.nih.gov/22589376 DMPVAUT DI DMPVAUT DMPVAUT DN CCX872 DMPVAUT MI TTFZYTO DMPVAUT MN C-C chemokine receptor type 2 (CCR2) DMPVAUT MT DTT DMPVAUT MA Inhibitor DMPVAUT RN Therapeutic use of a clinical stage CCR2 inhibitor, CCX872, in obesity-associated steatohepatitis. The Lancet Volume 383, Supplement 1, 26 February 2014, Pages S78. DMPVAUT RU http://www.sciencedirect.com/science/article/pii/S014067361460341X DMEK580 DI DMEK580 DMEK580 DN CD19 CAR T cells DMEK580 MI TTW640A DMEK580 MN B-lymphocyte surface antigen B4 (CD19) DMEK580 MT DTT DMEK580 MA CAR-T-Cell-Therapy DMEK580 RN ClinicalTrials.gov (NCT02846584) a Clinical Research of Sequential CAR-T Bridging HSCT in the Treatment of Relapse/Refractory B-cell Malignancies DMEK580 RU https://clinicaltrials.gov/ct2/show/NCT02846584 DMQJBUK DI DMQJBUK DMQJBUK DN CD19-targeting CAR T cells DMQJBUK MI TTW640A DMQJBUK MN B-lymphocyte surface antigen B4 (CD19) DMQJBUK MT DTT DMQJBUK MA CAR-T-Cell-Therapy DMQJBUK RN ClinicalTrials.gov (NCT02132624) CD19-targeting 3rd Generation CAR T Cells for Refractory B Cell Malignancy - a Phase I/IIa Trial. DMQJBUK RU https://clinicaltrials.gov/ct2/show/NCT02132624 DMQGI8R DI DMQGI8R DMQGI8R DN CD20 CAR T cells DMQGI8R MI TTUE541 DMQGI8R MN Leukocyte surface antigen Leu-16 (CD20) DMQGI8R MT DTT DMQGI8R MA CAR-T-Cell-Therapy DMQGI8R RN ClinicalTrials.gov (NCT02846584) a Clinical Research of Sequential CAR-T Bridging HSCT in the Treatment of Relapse/Refractory B-cell Malignancies DMQGI8R RU https://clinicaltrials.gov/ct2/show/NCT02846584 DMXYLTI DI DMXYLTI DMXYLTI DN CDP323 DMXYLTI MI TT6S84X DMXYLTI MN Integrin alpha-4/beta-1 (ITGA4/B1) DMXYLTI MT DTT DMXYLTI MA Modulator DMXYLTI RN Pharmacodynamic consequences of administration of VLA-4 antagonist CDP323 to multiple sclerosis subjects: a randomized, double-blind phase 1/2 study.PLoS One.2013;8(3):e58438. DMXYLTI RU https://www.ncbi.nlm.nih.gov/pubmed/23472197 DM3YB2C DI DM3YB2C DM3YB2C DN CDP-6038 DM3YB2C MI TTT1V78 DM3YB2C MN Interleukin-6 (IL6) DM3YB2C MT DTT DM3YB2C MA Modulator DM3YB2C RN Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41. DM3YB2C RU https://www.ncbi.nlm.nih.gov/pubmed/15950434 DM8UQJG DI DM8UQJG DM8UQJG DN CDX-1307 DM8UQJG MI TTUH273 DM8UQJG MN Choriogonadotropin beta (CG-beta) DM8UQJG MT DTT DM8UQJG RN CDX-1307: a novel vaccine under study as treatment for muscle-invasive bladder cancer. Expert Rev Vaccines. 2011 Jun;10(6):733-42. DM8UQJG RU https://pubmed.ncbi.nlm.nih.gov/21692696 DMCGNJ6 DI DMCGNJ6 DMCGNJ6 DN CDX-1401 DMCGNJ6 MI TTE5ITK DMCGNJ6 MN Cancer/testis antigen 1 (NY-ESO-1) DMCGNJ6 MT DTT DMCGNJ6 MA Modulator DMCGNJ6 RN National Cancer Institute Drug Dictionary (drug id 651880). DMCGNJ6 RU http://www.cancer.gov/publications/dictionaries/cancer-drug?cdrid=651880 DMKRFCO DI DMKRFCO DMKRFCO DN CDX-301 DMKRFCO MI TTGJCWZ DMKRFCO MN Fms-like tyrosine kinase 3 (FLT-3) DMKRFCO MT DTT DMKRFCO MA Inhibitor DMKRFCO RN Efficacy and safety of CDX-301, recombinant human Flt3L, at expanding dendritic cells and hematopoietic stem cells in healthy human volunteers. Bone Marrow Transplant. 2015 Jul;50(7):924-30. DMKRFCO RU https://pubmed.ncbi.nlm.nih.gov/25915810 DM5GKYD DI DM5GKYD DM5GKYD DN CDX-3379 DM5GKYD MI TTDC8N2 DM5GKYD MN Erbb3 tyrosine kinase receptor (Erbb-3) DM5GKYD MT DTT DM5GKYD MA Antagonist DM5GKYD RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DM5GKYD RU http://phrma-docs.phrma.org/files/dmfile/MID_Immuno-Oncology-2017_Drug-List1.pdf DM6Z9BV DI DM6Z9BV DM6Z9BV DN CeaVac DM6Z9BV MI TTY6DTE DM6Z9BV MN Carcinoembryonic antigen CEA (CD66e) DM6Z9BV MT DTT DM6Z9BV RN Clinical and immune responses in resected colon cancer patients treated with anti-idiotype monoclonal antibody vaccine that mimics the carcinoembryonic antigen. J Clin Oncol. 1999 Sep;17(9):2889-5. DM6Z9BV RU https://pubmed.ncbi.nlm.nih.gov/10561367 DM1S2FZ DI DM1S2FZ DM1S2FZ DN Cemdisiran DM1S2FZ MI TT2LJRF DM1S2FZ MN C5 messenger RNA (C5 mRNA) DM1S2FZ MT DTT DM1S2FZ MA Inhibitor DM1S2FZ RN Clinical pipeline report, company report or official report of Alnylam Pharmaceuticals. DM1S2FZ RU https://www.alnylam.com/alnylam-rnai-pipeline/ DMCT8EY DI DMCT8EY DMCT8EY DN Cenderitide DMCT8EY MI TTJME02 DMCT8EY MN Atrial natriuretic peptide receptor A (NPR1) DMCT8EY MT DTT DMCT8EY MA Agonist DMCT8EY RN 2011 Pipeline of Nile Therapeutics. DMCT8EY RU http://www.nilethera.com/pipeline.html DMU3P1K DI DMU3P1K DMU3P1K DN Cenerimod DMU3P1K MI TT2DLFI DMU3P1K MN Lysosphingolipid receptor (LSPR) DMU3P1K MT DTT DMU3P1K MA Agonist DMU3P1K RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMU3P1K RU http://phrma-docs.phrma.org/files/dmfile/medicines-in-development-drug-list-autoimmune-diseases.pdf DMMN21R DI DMMN21R DMMN21R DN Cenersen DMMN21R MI TT12KOD DMMN21R MN P53 messenger RNA (TP53 mRNA) DMMN21R MT DTT DMMN21R RN Phase 2 randomized study of p53 antisense oligonucleotide (cenersen) plus idarubicin with or without cytarabine in refractory and relapsed acute myeloid leukemia. Cancer. 2012 Jan 15;118(2):418-27. DMMN21R RU https://pubmed.ncbi.nlm.nih.gov/21717444 DM4V8WF DI DM4V8WF DM4V8WF DN Cenicriviroc DM4V8WF MI TTFZYTO DM4V8WF MN C-C chemokine receptor type 2 (CCR2) DM4V8WF MT DTT DM4V8WF MA Antagonist DM4V8WF RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DM4V8WF RU http://phrma-docs.phrma.org/files/dmfile/2017-HIV-AIDS-MID-Drug-List.pdf DM4V8WF DI DM4V8WF DM4V8WF DN Cenicriviroc DM4V8WF MI TT2CEJG DM4V8WF MN C-C chemokine receptor type 5 (CCR5) DM4V8WF MT DTT DM4V8WF MA Modulator DM4V8WF RN The dual CCR5 and CCR2 inhibitor cenicriviroc does not redistribute HIV into extracellular space: implications for plasma viral load and intracellular DNA decline. J Antimicrob Chemother. 2015 Mar;70(3):750-6. DM4V8WF RU https://pubmed.ncbi.nlm.nih.gov/25433008 DM4V8WF DI DM4V8WF DM4V8WF DN Cenicriviroc DM4V8WF MI DES5XRU DM4V8WF MN Cytochrome P450 2C8 (CYP2C8) DM4V8WF MT DME DM4V8WF MA Metabolism DM4V8WF RN Pharmacokinetics, safety, and CCR2/CCR5 antagonist activity of cenicriviroc in participants with mild or moderate hepatic impairment. Clin Transl Sci. 2016 Jun;9(3):139-48. DM4V8WF RU https://ascpt.onlinelibrary.wiley.com/doi/full/10.1111/cts.12397 DM4V8WF DI DM4V8WF DM4V8WF DN Cenicriviroc DM4V8WF MI DE4LYSA DM4V8WF MN Cytochrome P450 3A4 (CYP3A4) DM4V8WF MT DME DM4V8WF MA Metabolism DM4V8WF RN Pharmacokinetics, safety, and CCR2/CCR5 antagonist activity of cenicriviroc in participants with mild or moderate hepatic impairment. Clin Transl Sci. 2016 Jun;9(3):139-48. DM4V8WF RU https://ascpt.onlinelibrary.wiley.com/doi/full/10.1111/cts.12397 DMWUQI9 DI DMWUQI9 DMWUQI9 DN CER-001 DMWUQI9 MI TT7GN3U DMWUQI9 MN Apolipoprotein A-I (APOA1) DMWUQI9 MT DTT DMWUQI9 MA Modulator DMWUQI9 RN Clinical pipeline report, company report or official report of Cerenis. DMWUQI9 RU http://www.cerenis.com/en/our-therapies/cer-001 DMSABRI DI DMSABRI DMSABRI DN CERC-301 DMSABRI MI TTN9D8E DMSABRI MN Glutamate receptor ionotropic NMDA 2B (NMDAR2B) DMSABRI MT DTT DMSABRI MA Antagonist DMSABRI RN Inhibition of in vivo [(3)H]MK-801 binding by NMDA receptor open channel blockers and GluN2B antagonists in rats and mice. Eur J Pharmacol. 2015 Nov 5;766:1-8. DMSABRI RU https://pubmed.ncbi.nlm.nih.gov/26325093 DM3SZ7P DI DM3SZ7P DM3SZ7P DN CERC-801 DM3SZ7P MI DE3OP9S DM3SZ7P MN Galactose kinase (GALK1) DM3SZ7P MT DME DM3SZ7P MA Metabolism DM3SZ7P RN Molecular and biochemical characterization of human galactokinase and its small molecule inhibitors. Chem Biol Interact. 2010 Dec 5;188(3):376-85. DM3SZ7P RU https://www.ncbi.nlm.nih.gov/pubmed/?term=20696150 DM3SZ7P DI DM3SZ7P DM3SZ7P DN CERC-801 DM3SZ7P MI DEVSIE6 DM3SZ7P MN Glyceraldehyde-3-phosphate dehydrogenase (gap) DM3SZ7P MT DME DM3SZ7P MA Metabolism DM3SZ7P RN Cloning, expression and characterization of a mucin-binding GAPDH from Lactobacillus acidophilus. Int J Biol Macromol. 2016 Oct;91:338-46. DM3SZ7P RU https://pubmed.ncbi.nlm.nih.gov/27180300 DM3SZ7P DI DM3SZ7P DM3SZ7P DN CERC-801 DM3SZ7P MI DETP28W DM3SZ7P MN L-arabinose isomerase (araA) DM3SZ7P MT DME DM3SZ7P MA Metabolism DM3SZ7P RN The acid tolerant L-arabinose isomerase from the food grade Lactobacillus sakei 23K is an attractive D-tagatose producer. Bioresour Technol. 2010 Dec;101(23):9171-7. DM3SZ7P RU https://pubmed.ncbi.nlm.nih.gov/20688514 DM3SZ7P DI DM3SZ7P DM3SZ7P DN CERC-801 DM3SZ7P MI DEU37LK DM3SZ7P MN L-arabinose isomerase (araA) DM3SZ7P MT DME DM3SZ7P MA Metabolism DM3SZ7P RN Biochemical properties of L-arabinose isomerase from Clostridium hylemonae to produce D-tagatose as a functional sweetener. PLoS One. 2018 Apr 23;13(4):e0196099. DM3SZ7P RU https://pubmed.ncbi.nlm.nih.gov/29684065 DM3SZ7P DI DM3SZ7P DM3SZ7P DN CERC-801 DM3SZ7P MI DEYWLRK DM3SZ7P MN Sulfotransferase 1A1 (SULT1A1) DM3SZ7P MT DME DM3SZ7P MA Metabolism DM3SZ7P RN Sulfation of the galactose residues in the glycosaminoglycan-protein linkage region by recombinant human chondroitin 6-O-sulfotransferase-1. J Biol Chem. 2008 Oct 10;283(41):27438-43. DM3SZ7P RU https://www.ncbi.nlm.nih.gov/pubmed/?term=18697746 DMSCR2H DI DMSCR2H DMSCR2H DN Cerdulatinib DMSCR2H MI TT6DM01 DMSCR2H MN Janus kinase 1 (JAK-1) DMSCR2H MT DTT DMSCR2H MA Inhibitor DMSCR2H RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMSCR2H RU http://phrma-docs.phrma.org/files/dmfile/MID_Skin_Diseases_2018_9_FINAL.pdf DMSCR2H DI DMSCR2H DMSCR2H DN Cerdulatinib DMSCR2H MI TTRMX3V DMSCR2H MN Janus kinase 2 (JAK-2) DMSCR2H MT DTT DMSCR2H MA Modulator DMSCR2H RN Company report (Portola Pharmaceuticals) DMSCR2H RU https://www.portola.com/blog/cerdulatinib-a-unique-and-promising-investigational-treatment-for-patients-with-hematologic-cancers/ DMSCR2H DI DMSCR2H DMSCR2H DN Cerdulatinib DMSCR2H MI TTT7PJU DMSCR2H MN Janus kinase 3 (JAK-3) DMSCR2H MT DTT DMSCR2H MA Inhibitor DMSCR2H RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMSCR2H RU http://phrma-docs.phrma.org/files/dmfile/MID_Skin_Diseases_2018_9_FINAL.pdf DMSCR2H DI DMSCR2H DMSCR2H DN Cerdulatinib DMSCR2H MI TTOU65C DMSCR2H MN Tyrosine-protein kinase SYK (SYK) DMSCR2H MT DTT DMSCR2H MA Modulator DMSCR2H RN Company report (Portola Pharmaceuticals) DMSCR2H RU https://www.portola.com/blog/cerdulatinib-a-unique-and-promising-investigational-treatment-for-patients-with-hematologic-cancers/ DMNW5I9 DI DMNW5I9 DMNW5I9 DN CERE-110 DMNW5I9 MI TTDN3LF DMNW5I9 MN Nerve growth factor (NGF) DMNW5I9 MT DTT DMNW5I9 MA Modulator DMNW5I9 RN CERE-110, an adeno-associated virus-based gene delivery vector expressing human nerve growth factor for the treatment of Alzheimer's disease. Curr Opin Mol Ther. 2010 Apr;12(2):240-7. DMNW5I9 RU https://pubmed.ncbi.nlm.nih.gov/20373268 DMS01AX DI DMS01AX DMS01AX DN CERE-120 DMS01AX MI TTWFC4G DMS01AX MN Netrin (NET) DMS01AX MT DTT DMS01AX MA Modulator DMS01AX RN Striatal delivery of neurturin by CERE-120, an AAV2 vector for the treatment of dopaminergic neuron degeneration in Parkinson's disease. Mol Ther. 2007 Jan;15(1):62-8. DMS01AX RU https://pubmed.ncbi.nlm.nih.gov/17164776 DMAWKSM DI DMAWKSM DMAWKSM DN CetuGEX DMAWKSM MI TTGKNB4 DMAWKSM MN Epidermal growth factor receptor (EGFR) DMAWKSM MT DTT DMAWKSM RN Molecular mechanisms of resistance to the EGFR monoclonal antibody cetuximab. Cancer Biol Ther. 2011 May 1;11(9):777-92. DMAWKSM RU https://pubmed.ncbi.nlm.nih.gov/21293176 DMP56WJ DI DMP56WJ DMP56WJ DN CF102 DMP56WJ MI TTJFY5U DMP56WJ MN Adenosine A3 receptor (ADORA3) DMP56WJ MT DTT DMP56WJ MA Agonist DMP56WJ RN 2011 Pipeline of Can-Fite BioPharm. DMP56WJ RU http://www.canfite.com/pipeline.html DM3BN4W DI DM3BN4W DM3BN4W DN CFI-400945 DM3BN4W MI TTGPNZQ DM3BN4W MN Polo-like kinase 4 (PLK4) DM3BN4W MT DTT DM3BN4W MA Inhibitor DM3BN4W RN Functional characterization of CFI-400945, a Polo-like kinase 4 inhibitor, as a potential anticancer agent. Cancer Cell. 2014 Aug 11;26(2):163-76. DM3BN4W RU https://pubmed.ncbi.nlm.nih.gov/25043604 DM1TWIE DI DM1TWIE DM1TWIE DN CFZ533 DM1TWIE MI TTN6Y9A DM1TWIE MN CD40L receptor (CD40) DM1TWIE MT DTT DM1TWIE MA Inhibitor DM1TWIE RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DM1TWIE RU http://phrma-docs.phrma.org/files/dmfile/medicines-in-development-drug-list-autoimmune-diseases.pdf DMWY609 DI DMWY609 DMWY609 DN CG201 DMWY609 MI TT0ID4A DMWY609 MN Leutinizing-hormone-releasing hormone (GNRH1) DMWY609 MT DTT DMWY609 MA Modulator DMWY609 RN Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41. DMWY609 RU https://www.ncbi.nlm.nih.gov/pubmed/15950434 DMFAKGR DI DMFAKGR DMFAKGR DN CG-400549 DMFAKGR MI TTZBRVL DMFAKGR MN Staphylococcus Enoyl ACP reductase (Stap-coc fabI) DMFAKGR MT DTT DMFAKGR MA Inhibitor DMFAKGR RN In vitro activities of CG400549, a novel FabI inhibitor, against recently isolated clinical staphylococcal strains in Korea. Antimicrob Agents Chemother. 2007 Jul;51(7):2591-3. DMFAKGR RU https://pubmed.ncbi.nlm.nih.gov/17420210 DM17JSI DI DM17JSI DM17JSI DN CGC-11047 DM17JSI MI TTUTN1I DM17JSI MN Human Deoxyribonucleic acid (hDNA) DM17JSI MT DTT DM17JSI MA Modulator DM17JSI RN Gene expression analysis of HCT116 colon tumor-derived cells treated with the polyamine analog PG-11047. Cancer Genomics Proteomics. 2009 May-Jun;6(3):161-75. DM17JSI RU https://pubmed.ncbi.nlm.nih.gov/19487545 DMYNTQV DI DMYNTQV DMYNTQV DN CGP-28014 DMYNTQV MI TTKWFB8 DMYNTQV MN Catechol-O-methyl-transferase (COMT) DMYNTQV MT DTT DMYNTQV MA Modulator DMYNTQV RN CGP 28014, a new inhibitor of cerebral catechol-O-methylation with a non-catechol structure. Naunyn Schmiedebergs Arch Pharmacol. 1990 Sep;342(3):305-11. DMYNTQV RU https://pubmed.ncbi.nlm.nih.gov/1980718 DMKS7RJ DI DMKS7RJ DMKS7RJ DN CGS-15873A DMKS7RJ MI TTEX248 DMKS7RJ MN Dopamine D2 receptor (D2R) DMKS7RJ MT DTT DMKS7RJ MA Modulator DMKS7RJ RN Biochemical and pharmacological characterization of the putative dopamine autoreceptor agonist benzopyranopyridine, CGS 15873A. Article first published online: 5 OCT 2004. DMKS7RJ RU http://onlinelibrary.wiley.com/doi/10.1002/ddr.430180303/abstract DMLQRYH DI DMLQRYH DMLQRYH DN CH-4051 DMLQRYH MI TTYZVDJ DMLQRYH MN Dihydrofolate reductase (DHFR) DMLQRYH MT DTT DMLQRYH MA Inhibitor DMLQRYH RN CH-1504, a metabolically inert antifolate for the potential treatment of rheumatoid arthritis. IDrugs. 2010 Aug;13(8):559-67. DMLQRYH RU https://pubmed.ncbi.nlm.nih.gov/20721827 DMQ2O8V DI DMQ2O8V DMQ2O8V DN CHF-3381 DMQ2O8V MI TT3WG5C DMQ2O8V MN Monoamine oxidase type A (MAO-A) DMQ2O8V MT DTT DMQ2O8V MA Inhibitor DMQ2O8V RN Emerging drugs in neuropathic pain. Expert Opin Emerg Drugs. 2007 Mar;12(1):113-26. DMQ2O8V RU https://pubmed.ncbi.nlm.nih.gov/17355217 DMQ2O8V DI DMQ2O8V DMQ2O8V DN CHF-3381 DMQ2O8V MI TTGP7BY DMQ2O8V MN Monoamine oxidase type B (MAO-B) DMQ2O8V MT DTT DMQ2O8V MA Inhibitor DMQ2O8V RN Emerging drugs in neuropathic pain. Expert Opin Emerg Drugs. 2007 Mar;12(1):113-26. DMQ2O8V RU https://pubmed.ncbi.nlm.nih.gov/17355217 DMQ2O8V DI DMQ2O8V DMQ2O8V DN CHF-3381 DMQ2O8V MI TT9IK2Z DMQ2O8V MN N-methyl-D-aspartate receptor (NMDAR) DMQ2O8V MT DTT DMQ2O8V MA Antagonist DMQ2O8V RN Emerging drugs in neuropathic pain. Expert Opin Emerg Drugs. 2007 Mar;12(1):113-26. DMQ2O8V RU https://pubmed.ncbi.nlm.nih.gov/17355217 DMTE071 DI DMTE071 DMTE071 DN CHF-5074 DMTE071 MI TT9W8GU DMTE071 MN Gamma-secretase (GS) DMTE071 MT DTT DMTE071 MA Modulator DMTE071 RN CHF5074, a novel gamma-secretase modulator, attenuates brain beta-amyloid pathology and learning deficit in a mouse model of Alzheimer's disease.Br J Pharmacol.2009 Mar;156(6):982-93. DMTE071 RU https://www.ncbi.nlm.nih.gov/pubmed/19239474 DMALN2M DI DMALN2M DMALN2M DN Cholyl lysyl fluorescein DMALN2M MI DTQ3ZHF DMALN2M MN Multidrug resistance-associated protein 3 (ABCC3) DMALN2M MT DTP DMALN2M MA Substrate DMALN2M RN The emerging role of transport systems in liver function tests. Eur J Pharmacol. 2012 Jan 30;675(1-3):1-5. DMALN2M RU https://doi.org/10.1016/j.ejphar.2011.11.048 DMALN2M DI DMALN2M DMALN2M DN Cholyl lysyl fluorescein DMALN2M MI DT3D8F0 DMALN2M MN Organic anion transporting polypeptide 1B1 (SLCO1B1) DMALN2M MT DTP DMALN2M MA Substrate DMALN2M RN Organic anion transporting polypeptide 1B1: a genetically polymorphic transporter of major importance for hepatic drug uptake. Pharmacol Rev. 2011 Mar;63(1):157-81. DMALN2M RU http://www.ncbi.nlm.nih.gov/pubmed/21245207 DMULZ4W DI DMULZ4W DMULZ4W DN CHR-2797 DMULZ4W MI TTWLEZV DMULZ4W MN Aminopeptidase (AMP) DMULZ4W MT DTT DMULZ4W MA Inhibitor DMULZ4W RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMULZ4W RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DMULZ4W DI DMULZ4W DMULZ4W DN CHR-2797 DMULZ4W MI TT371QC DMULZ4W MN Puromycin-sensitive aminopeptidase (NPEPPS) DMULZ4W MT DTT DMULZ4W MA Inhibitor DMULZ4W RN CHR-2797: an antiproliferative aminopeptidase inhibitor that leads to amino acid deprivation in human leukemic cells. Cancer Res. 2008 Aug 15;68(16):6669-79. DMULZ4W RU https://pubmed.ncbi.nlm.nih.gov/18701491 DMMRKPF DI DMMRKPF DMMRKPF DN CHS-131 DMMRKPF MI TTZMAO3 DMMRKPF MN Peroxisome proliferator-activated receptor gamma (PPAR-gamma) DMMRKPF MT DTT DMMRKPF MA Modulator DMMRKPF RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMMRKPF RU http://phrma-docs.phrma.org/files/dmfile/medicines-in-development-drug-list-autoimmune-diseases.pdf DMLRTN1 DI DMLRTN1 DMLRTN1 DN CI-1012 DMLRTN1 MI TT3NH7G DMLRTN1 MN Human immunodeficiency virus Deoxyribonucleic acid (HIV DNA) DMLRTN1 MT DTT DMLRTN1 MA Inhibitor DMLRTN1 RN WO patent application no. 2006,0835,53, Diketo acids with nucleobase scaffolds: anti-hiv replication inhibitors targeted at hiv integrase. DMLRTN1 RU http://worldwide.espacenet.com/publicationDetails/biblio?DB=worldwide.espacenet.com&II=0&ND=3&adjacent=true&locale=en_EP&FT=D&date=20060810&CC=WO&NR=2006083553A2&KC=A2 DMSI8N3 DI DMSI8N3 DMSI8N3 DN CI-1033 DMSI8N3 MI TTGKNB4 DMSI8N3 MN Epidermal growth factor receptor (EGFR) DMSI8N3 MT DTT DMSI8N3 MA Inhibitor DMSI8N3 RN A comparison of physicochemical property profiles of marketed oral drugs and orally bioavailable anti-cancer protein kinase inhibitors in clinical development. Curr Top Med Chem. 2007;7(14):1408-22. DMSI8N3 RU https://pubmed.ncbi.nlm.nih.gov/17692029 DMSI8N3 DI DMSI8N3 DMSI8N3 DN CI-1033 DMSI8N3 MI TT6EO5L DMSI8N3 MN Erbb2 tyrosine kinase receptor (HER2) DMSI8N3 MT DTT DMSI8N3 MA Inhibitor DMSI8N3 RN A comparison of physicochemical property profiles of marketed oral drugs and orally bioavailable anti-cancer protein kinase inhibitors in clinical development. Curr Top Med Chem. 2007;7(14):1408-22. DMSI8N3 RU https://pubmed.ncbi.nlm.nih.gov/17692029 DMSI8N3 DI DMSI8N3 DMSI8N3 DN CI-1033 DMSI8N3 MI TT0JESD DMSI8N3 MN Erbb4 tyrosine kinase receptor (Erbb-4) DMSI8N3 MT DTT DMSI8N3 MA Inhibitor DMSI8N3 RN A comparison of physicochemical property profiles of marketed oral drugs and orally bioavailable anti-cancer protein kinase inhibitors in clinical development. Curr Top Med Chem. 2007;7(14):1408-22. DMSI8N3 RU https://pubmed.ncbi.nlm.nih.gov/17692029 DMSI8N3 DI DMSI8N3 DMSI8N3 DN CI-1033 DMSI8N3 MI TTWTSCV DMSI8N3 MN RAC-alpha serine/threonine-protein kinase (AKT1) DMSI8N3 MT DTT DMSI8N3 MA Inhibitor DMSI8N3 RN A comparison of physicochemical property profiles of marketed oral drugs and orally bioavailable anti-cancer protein kinase inhibitors in clinical development. Curr Top Med Chem. 2007;7(14):1408-22. DMSI8N3 RU https://pubmed.ncbi.nlm.nih.gov/17692029 DMCFLRH DI DMCFLRH DMCFLRH DN Cibinetide DMCFLRH MI TTAUX24 DMCFLRH MN Erythropoietin Receptor (EPOR) DMCFLRH MT DTT DMCFLRH MA Agonist DMCFLRH RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMCFLRH RU http://phrma-docs.phrma.org/files/dmfile/MID_Neurological-Disorders-Drug-List_2018.pdf DMGTZLW DI DMGTZLW DMGTZLW DN Cicletanine DMGTZLW MI DEYGVN4 DMGTZLW MN UDP-glucuronosyltransferase 1A1 (UGT1A1) DMGTZLW MT DME DMGTZLW MA Metabolism DMGTZLW RN Induction and inhibition of cicletanine metabolism in cultured hepatocytes and liver microsomes from rats. Fundam Clin Pharmacol. 2000 Sep-Oct;14(5):509-18. DMGTZLW RU https://www.ncbi.nlm.nih.gov/pubmed/?term=11129092 DMTKSVA DI DMTKSVA DMTKSVA DN CIMICOXIB DMTKSVA MI TTVKILB DMTKSVA MN Prostaglandin G/H synthase 2 (COX-2) DMTKSVA MT DTT DMTKSVA MA Modulator DMTKSVA RN Pharmacokinetic profiles of the novel COX-2 selective inhibitor cimicoxib in dogs.Vet J.2014 Apr;200(1):77-81. DMTKSVA RU https://www.ncbi.nlm.nih.gov/pubmed/24461644 DMGEAM6 DI DMGEAM6 DMGEAM6 DN Cinaciguat DMGEAM6 MI TTLBYH1 DMGEAM6 MN Guanylate cyclase soluble beta-1 (GUCY1B1) DMGEAM6 MT DTT DMGEAM6 MA Activator DMGEAM6 RN Cinaciguat (BAY 58-2667) improves cardiopulmonary hemodynamics in patients with acute decompensated heart failure. Circulation. 2009 Jun 2;119(21):2781-8. DMGEAM6 RU https://pubmed.ncbi.nlm.nih.gov/19451356 DM98RW0 DI DM98RW0 DM98RW0 DN Cirmtuzumab DM98RW0 MI TTDEJAU DM98RW0 MN Neurotrophic tyrosine kinase ROR1 (ROR1) DM98RW0 MT DTT DM98RW0 MA Antagonist DM98RW0 RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DM98RW0 RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DMNRYPF DI DMNRYPF DMNRYPF DN Cixutumumab DMNRYPF MI TTHRID2 DMNRYPF MN Insulin-like growth factor I receptor (IGF1R) DMNRYPF MT DTT DMNRYPF MA Modulator DMNRYPF RN Doxorubicin plus the IGF-1R antibody cixutumumab in soft tissue sarcoma: a phase I study using the TITE-CRM model. Ann Oncol. 2015 Jul;26(7):1459-64. DMNRYPF RU https://pubmed.ncbi.nlm.nih.gov/25858498 DMOFTRE DI DMOFTRE DMOFTRE DN Cizolirtine DMOFTRE MI TTVSFJW DMOFTRE MN Calcitonin gene-related peptide 1 (CALCA) DMOFTRE MT DTT DMOFTRE MA Inhibitor DMOFTRE RN Emerging drugs in neuropathic pain. Expert Opin Emerg Drugs. 2007 Mar;12(1):113-26. DMOFTRE RU https://pubmed.ncbi.nlm.nih.gov/17355217 DMTSVJM DI DMTSVJM DMTSVJM DN CJM112 DMTSVJM MI TTG0MT6 DMTSVJM MN Interleukin-17 (IL17) DMTSVJM MT DTT DMTSVJM MA Inhibitor DMTSVJM RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMTSVJM RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DM9FHV8 DI DM9FHV8 DM9FHV8 DN CK-2127107 DM9FHV8 MI TTYUMF5 DM9FHV8 MN Fast skeletal muscle troponin complex (TNNC2) DM9FHV8 MT DTT DM9FHV8 MA Modulator DM9FHV8 RN Activation of fast skeletal muscle troponin as a potential therapeutic approach for treating neuromuscular diseases. Nat Med. 2012 Feb 19;18(3):452-5. DM9FHV8 RU https://pubmed.ncbi.nlm.nih.gov/22344294 DMW9F1G DI DMW9F1G DMW9F1G DN CKD602 DMW9F1G MI DTI7UX6 DMW9F1G MN Breast cancer resistance protein (ABCG2) DMW9F1G MT DTP DMW9F1G MA Substrate DMW9F1G RN Involvement of P-glycoprotein, multidrug resistance protein 2 and breast cancer resistance protein in the transport of belotecan and topotecan in Caco-2 and MDCKII cells. Pharm Res. 2008 Nov;25(11):2601-12. DMW9F1G RU http://www.ncbi.nlm.nih.gov/pubmed/18654741 DMW9F1G DI DMW9F1G DMW9F1G DN CKD602 DMW9F1G MI TTGTQHC DMW9F1G MN DNA topoisomerase I (TOP1) DMW9F1G MT DTT DMW9F1G MA Inhibitor DMW9F1G RN Antitumor activity of 7-[2-(N-isopropylamino)ethyl]-(20S)-camptothecin, CKD602, as a potent DNA topoisomerase I inhibitor. Arch Pharm Res. 1998 Oct;21(5):581-90. DMW9F1G RU https://pubmed.ncbi.nlm.nih.gov/9875499 DMW9F1G DI DMW9F1G DMW9F1G DN CKD602 DMW9F1G MI DTFI42L DMW9F1G MN Multidrug resistance-associated protein 2 (ABCC2) DMW9F1G MT DTP DMW9F1G MA Substrate DMW9F1G RN Human intestinal transporter database: QSAR modeling and virtual profiling of drug uptake, efflux and interactions. Pharm Res. 2013 Apr;30(4):996-1007. DMW9F1G RU https://doi.org/10.1007/s11095-012-0935-x DMW9F1G DI DMW9F1G DMW9F1G DN CKD602 DMW9F1G MI DTUGYRD DMW9F1G MN P-glycoprotein 1 (ABCB1) DMW9F1G MT DTP DMW9F1G MA Substrate DMW9F1G RN Human intestinal transporter database: QSAR modeling and virtual profiling of drug uptake, efflux and interactions. Pharm Res. 2013 Apr;30(4):996-1007. DMW9F1G RU https://doi.org/10.1007/s11095-012-0935-x DMXH1KC DI DMXH1KC DMXH1KC DN CL-316,243 DMXH1KC MI TTMXGCW DMXH1KC MN Adrenergic receptor beta-3 (ADRB3) DMXH1KC MT DTT DMXH1KC MA Agonist DMXH1KC RN Beta 3-adrenoceptor agonists as anti-diabetic and anti-obesity drugs in humans. Curr Pharm Des. 2001 Sep;7(14):1433-49. DMXH1KC RU https://pubmed.ncbi.nlm.nih.gov/11472270 DMXH1KC DI DMXH1KC DMXH1KC DN CL-316,243 DMXH1KC MI TTI12YJ DMXH1KC MN Mitochondrial uncoupling protein 1 (UCP1) DMXH1KC MT DTT DMXH1KC MA Inducer DMXH1KC RN Anti-obesity and anti-diabetic effects of CL316,243, a highly specific beta 3-adrenoceptor agonist, in Otsuka Long-Evans Tokushima Fatty rats: induction of uncoupling protein and activation of glucose transporter 4 in white fat. Eur J Endocrinol. 1997 Apr;136(4):429-37. DMXH1KC RU https://pubmed.ncbi.nlm.nih.gov/9150705 DMXH1KC DI DMXH1KC DMXH1KC DN CL-316,243 DMXH1KC MI TTSC2YM DMXH1KC MN Mitochondrial uncoupling protein 2 (UCP2) DMXH1KC MT DTT DMXH1KC MA Inducer DMXH1KC RN Anti-obesity and anti-diabetic effects of CL316,243, a highly specific beta 3-adrenoceptor agonist, in Otsuka Long-Evans Tokushima Fatty rats: induction of uncoupling protein and activation of glucose transporter 4 in white fat. Eur J Endocrinol. 1997 Apr;136(4):429-37. DMXH1KC RU https://pubmed.ncbi.nlm.nih.gov/9150705 DMXH1KC DI DMXH1KC DMXH1KC DN CL-316,243 DMXH1KC MI TT12RJK DMXH1KC MN Mitochondrial uncoupling protein 3 (UCP3) DMXH1KC MT DTT DMXH1KC MA Inducer DMXH1KC RN Anti-obesity and anti-diabetic effects of CL316,243, a highly specific beta 3-adrenoceptor agonist, in Otsuka Long-Evans Tokushima Fatty rats: induction of uncoupling protein and activation of glucose transporter 4 in white fat. Eur J Endocrinol. 1997 Apr;136(4):429-37. DMXH1KC RU https://pubmed.ncbi.nlm.nih.gov/9150705 DMSF7WJ DI DMSF7WJ DMSF7WJ DN CL-329167 DMSF7WJ MI TT8DBY3 DMSF7WJ MN Angiotensin II receptor type-1 (AGTR1) DMSF7WJ MT DTT DMSF7WJ MA Antagonist DMSF7WJ RN Distribution and function of cardiac angiotensin AT1- and AT2-receptor subtypes in hypertrophied rat hearts. Am J Physiol. 1994 Aug;267(2 Pt 2):H844-52. DMSF7WJ RU https://pubmed.ncbi.nlm.nih.gov/8067441 DM6ZOUV DI DM6ZOUV DM6ZOUV DN Clazakizumab DM6ZOUV MI TTJH4Y5 DM6ZOUV MN HUMAN interleukin 6 (IL6) DM6ZOUV MT DTT DM6ZOUV MA Inhibitor DM6ZOUV RN Can we use interleukin-6 (IL-6) blockade for coronavirus disease 2019 (COVID-19)-induced cytokine release syndrome (CRS) J Autoimmun. 2020 Apr 10:102452. DM6ZOUV RU https://pubmed.ncbi.nlm.nih.gov/32291137 DMAIW6C DI DMAIW6C DMAIW6C DN Clazakizumab DMAIW6C MI TTT1V78 DMAIW6C MN Interleukin-6 (IL6) DMAIW6C MT DTT DMAIW6C MA Inhibitor DMAIW6C RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMAIW6C RU http://phrma-docs.phrma.org/files/dmfile/medicines-in-development-drug-list-autoimmune-diseases.pdf DMU6R3O DI DMU6R3O DMU6R3O DN CLG561 DMU6R3O MI TTLA0VS DMU6R3O MN Complement factor P (CFP) DMU6R3O MT DTT DMU6R3O MA Inhibitor DMU6R3O RN Complement inhibition as a therapeutic strategy in retinal disorders. Expert Opin Biol Ther. 2019 Apr;19(4):335-342. DMU6R3O RU https://pubmed.ncbi.nlm.nih.gov/30686077 DMH2VS0 DI DMH2VS0 DMH2VS0 DN CLP-1001 DMH2VS0 MI TTWN7KV DMH2VS0 MN Na-K-Cl cotransporter (NKCC) DMH2VS0 MT DTT DMH2VS0 MA Modulator DMH2VS0 RN Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800034446) DMH2VS0 RU http://adisinsight.springer.com/drugs/800034446 DMAW4EL DI DMAW4EL DMAW4EL DN CLR-1404 DMAW4EL MI TTHBTOP DMAW4EL MN PI3-kinase gamma (PIK3CG) DMAW4EL MT DTT DMAW4EL MA Inhibitor DMAW4EL RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2155). DMAW4EL RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2155 DM3Z6IQ DI DM3Z6IQ DM3Z6IQ DN CLR-3001 DM3Z6IQ MI TTEX248 DM3Z6IQ MN Dopamine D2 receptor (D2R) DM3Z6IQ MT DTT DM3Z6IQ MA Modulator DM3Z6IQ RN Clinical pipeline report, company report or official report of Clera Inc. DM3Z6IQ RU http://clera.com/cognition/ DM3Z6IQ DI DM3Z6IQ DM3Z6IQ DN CLR-3001 DM3Z6IQ MI TT3ROYC DM3Z6IQ MN Serotonin transporter (SERT) DM3Z6IQ MT DTT DM3Z6IQ MA Inhibitor DM3Z6IQ RN Clinical pipeline report, company report or official report of Clera Inc. DM3Z6IQ RU http://clera.com/cognition/ DMQSIY1 DI DMQSIY1 DMQSIY1 DN CLS003 DMQSIY1 MI TTL3N71 DMQSIY1 MN Virus Replication (Viru Repli) DMQSIY1 MT DTT DMQSIY1 MA Inhibitor DMQSIY1 RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMQSIY1 RU http://phrma-docs.phrma.org/files/dmfile/MID_Skin_Diseases_2018_9_FINAL.pdf DM1NCUY DI DM1NCUY DM1NCUY DN CMI-392 DM1NCUY MI TT2J34L DM1NCUY MN Arachidonate 5-lipoxygenase (5-LOX) DM1NCUY MT DTT DM1NCUY MA Modulator DM1NCUY RN Anti-inflammatory activities of LDP-392, a dual PAF receptor antagonist and 5-lipoxygenase inhibitor. Pharmacol Res. 2001 Sep;44(3):213-20. 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DMOR8SY RU https://pubmed.ncbi.nlm.nih.gov/25807335 DM6RQXB DI DM6RQXB DM6RQXB DN CNTO-6785 DM6RQXB MI TT69OHW DM6RQXB MN Interleukin 17 receptor (IL17R) DM6RQXB MT DTT DM6RQXB RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DM6RQXB RU http://phrma-docs.phrma.org/files/dmfile/medicines-in-development-drug-list-autoimmune-diseases.pdf DM6RQXB DI DM6RQXB DM6RQXB DN CNTO-6785 DM6RQXB MI TTG0MT6 DM6RQXB MN Interleukin-17 (IL17) DM6RQXB MT DTT DM6RQXB RN Targeting the IL-17-T(H)17 pathway. Nat Rev Drug Discov. 2015 Jan;14(1):11-2. DM6RQXB RU https://pubmed.ncbi.nlm.nih.gov/25549584 DMLT7JV DI DMLT7JV DMLT7JV DN CNV-2197944 DMLT7JV MI TT4FDG6 DMLT7JV MN Voltage-gated calcium channel alpha Cav2.2 (CACNA1B) DMLT7JV MT DTT DMLT7JV MA Blocker DMLT7JV RN Clinical pipeline report, company report or official report of Convergence Pharmaceuticals Ltd. DMLT7JV RU http://www.convergencepharma.com/index.asp?page_id=30 DMH5GQU DI DMH5GQU DMH5GQU DN CO-101 DMH5GQU MI TTUTN1I DMH5GQU MN Human Deoxyribonucleic acid (hDNA) DMH5GQU MT DTT DMH5GQU MA Inhibitor DMH5GQU RN Cellular pharmacology of gemcitabine. Ann Oncol. 2006 May;17 Suppl 5:v7-12. DMH5GQU RU https://pubmed.ncbi.nlm.nih.gov/16807468 DMH5GQU DI DMH5GQU DMH5GQU DN CO-101 DMH5GQU MI TTBWDI0 DMH5GQU MN Ribonucleoside-diphosphate reductase M2 (RRM2) DMH5GQU MT DTT DMH5GQU MA Inhibitor DMH5GQU RN Cellular pharmacology of gemcitabine. Ann Oncol. 2006 May;17 Suppl 5:v7-12. DMH5GQU RU https://pubmed.ncbi.nlm.nih.gov/16807468 DMF4MX9 DI DMF4MX9 DMF4MX9 DN Cobomarsen DMF4MX9 MI TT1GNRQ DMF4MX9 MN microRNA hsa-miR-155 (MIR155) DMF4MX9 MT DTT DMF4MX9 MA Inhibitor DMF4MX9 RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMF4MX9 RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DMDWG36 DI DMDWG36 DMDWG36 DN Codrituzumab DMDWG36 MI TTJTSX4 DMDWG36 MN Glypican-3 (GPC3) DMDWG36 MT DTT DMDWG36 MA Inhibitor DMDWG36 RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMDWG36 RU http://phrma-docs.phrma.org/files/dmfile/MID_Immuno-Oncology-2017_Drug-List1.pdf DMO0VGH DI DMO0VGH DMO0VGH DN Coenzyme Q10 analog DMO0VGH MI TT8XK6L DMO0VGH MN Quinone reductase 1 (NQO1) DMO0VGH MT DTT DMO0VGH MA Modulator DMO0VGH RN Therapeutic strategies for Leber's hereditary optic neuropathy: A current update. Intractable Rare Dis Res. 2013 November; 2(4): 130-135. DMO0VGH RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4204556/ DMNC76I DI DMNC76I DMNC76I DN COL-1077 DMNC76I MI TTRK8B9 DMNC76I MN Sodium channel unspecific (NaC) DMNC76I MT DTT DMNC76I MA Antagonist DMNC76I RN Clinical pipeline report, company report or official report of Columbia Laboratories. DMNC76I RU http://companies.einnews.com/news/columbia-laboratories-news DMSGFOY DI DMSGFOY DMSGFOY DN Coltuximab ravtansine DMSGFOY MI TTW640A DMSGFOY MN B-lymphocyte surface antigen B4 (CD19) DMSGFOY MT DTT DMSGFOY MA Inhibitor DMSGFOY RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMSGFOY RU http://phrma-docs.phrma.org/files/dmfile/MID_Immuno-Oncology-2017_Drug-List1.pdf DMI2GSK DI DMI2GSK DMI2GSK DN Coluracetam DMI2GSK MI TTAN6JD DMI2GSK MN Glutamate receptor AMPA (GRIA) DMI2GSK MT DTT DMI2GSK MA Modulator DMI2GSK RN MKC-231, a choline uptake enhancer: (2) Effect on synthesis and release of acetylcholine in AF64A-treated rats. J Neural Transm. 2008 Jul;115(7):1027-35. DMI2GSK RU https://pubmed.ncbi.nlm.nih.gov/18446264 DMGCTX5 DI DMGCTX5 DMGCTX5 DN Combined PR1/WT1 vaccine DMGCTX5 MI TT5MLC4 DMGCTX5 MN Leukocyte proteinase-3 (PRTN3) DMGCTX5 MT DTT DMGCTX5 RN Leukemia-associated antigen-specific T-cell responses following combined PR1 and WT1 peptide vaccination in patients with myeloid malignancies. Blood. 2008 Jan 1;111(1):236-42. DMGCTX5 RU https://pubmed.ncbi.nlm.nih.gov/17875804 DMGCTX5 DI DMGCTX5 DMGCTX5 DN Combined PR1/WT1 vaccine DMGCTX5 MI TTZ8UT4 DMGCTX5 MN Wilms tumor protein (WT1) DMGCTX5 MT DTT DMGCTX5 RN Leukemia-associated antigen-specific T-cell responses following combined PR1 and WT1 peptide vaccination in patients with myeloid malignancies. Blood. 2008 Jan 1;111(1):236-42. DMGCTX5 RU https://pubmed.ncbi.nlm.nih.gov/17875804 DM2UOSN DI DM2UOSN DM2UOSN DN Conatumumab DM2UOSN MI TT6OEDT DM2UOSN MN Cannabinoid receptor 1 (CB1) DM2UOSN MT DTT DM2UOSN MA Agonist DM2UOSN RN Clinical pipeline report, company report or official report of AstraZeneca (2009). DM2UOSN RU http://www.astrazeneca.com/_mshost3690701/content/resources/media/investors/AZN-Q2-2009/AZN-Q2-2009-Pipeline.pdf DM2UOSN DI DM2UOSN DM2UOSN DN Conatumumab DM2UOSN MI TTW20TU DM2UOSN MN TRAIL receptor 2 (TRAIL-R2) DM2UOSN MT DTT DM2UOSN MA Agonist DM2UOSN RN Clinical pipeline report, company report or official report of Amgen (2009). DM2UOSN RU http://www.amgen.com/science/pipe.jsp DM2UOSN DI DM2UOSN DM2UOSN DN Conatumumab DM2UOSN MI TT90XZ8 DM2UOSN MN Voltage-gated sodium channel alpha Nav1.8 (SCN10A) DM2UOSN MT DTT DM2UOSN MA Binder DM2UOSN RN Pathobiology of visceral pain: molecular mechanisms and therapeutic implications. II. Genetic approaches to pain therapy. 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DM2UOSN RU https://pubmed.ncbi.nlm.nih.gov/10762603 DMZ0F65 DI DMZ0F65 DMZ0F65 DN Contezolid DMZ0F65 MI TTLIZBJ DMZ0F65 MN Protein synthesis (hPRO synth) DMZ0F65 MT DTT DMZ0F65 MA Inhibitor DMZ0F65 RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMZ0F65 RU http://phrma-docs.phrma.org/files/dmfile/MID_Skin_Diseases_2018_9_FINAL.pdf DMMOHUA DI DMMOHUA DMMOHUA DN Contezolid acefosamil DMMOHUA MI TTLIZBJ DMMOHUA MN Protein synthesis (hPRO synth) DMMOHUA MT DTT DMMOHUA MA Inhibitor DMMOHUA RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMMOHUA RU http://phrma-docs.phrma.org/files/dmfile/MID_Skin_Diseases_2018_9_FINAL.pdf DMER82Z DI DMER82Z DMER82Z DN COR-1 DMER82Z MI TTR6W5O DMER82Z MN Adrenergic receptor beta-1 (ADRB1) DMER82Z MT DTT DMER82Z MA Antagonist DMER82Z RN Administration of the cyclic peptide COR-1 in humans (phase I study): ex vivo measurements of anti-beta1-adrenergic receptor antibody neutralization and of immune parameters. Eur J Heart Fail. 2012 Nov;14(11):1230-9. DMER82Z RU https://pubmed.ncbi.nlm.nih.gov/22968742 DMHBOUX DI DMHBOUX DMHBOUX DN CORT125281 DMHBOUX MI TTOZRK6 DMHBOUX MN Glucocorticoid receptor messenger RNA (GCR mRNA) DMHBOUX MT DTT DMHBOUX MA Antagonist DMHBOUX RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMHBOUX RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DMVKW0N DI DMVKW0N DMVKW0N DN Coumate DMVKW0N MI TTSZLWK DMVKW0N MN Aromatase (CYP19A1) DMVKW0N MT DTT DMVKW0N MA Inhibitor DMVKW0N RN Highly potent first examples of dual aromatase-steroid sulfatase inhibitors based on a biphenyl template. J Med Chem. 2010 Mar 11;53(5):2155-70. DMVKW0N RU https://pubmed.ncbi.nlm.nih.gov/20148564 DMVKW0N DI DMVKW0N DMVKW0N DN Coumate DMVKW0N MI TTUNARX DMVKW0N MN Carbonic anhydrase (CA) DMVKW0N MT DTT DMVKW0N MA Inhibitor DMVKW0N RN Carbonic anhydrase inhibitors. Interaction of the antitumor sulfamate EMD 486019 with twelve mammalian carbonic anhydrase isoforms: Kinetic and X-r... Bioorg Med Chem Lett. 2008 Aug 1;18(15):4282-6. DMVKW0N RU https://pubmed.ncbi.nlm.nih.gov/18640037 DMVKW0N DI DMVKW0N DMVKW0N DN Coumate DMVKW0N MI TTHQPL7 DMVKW0N MN Carbonic anhydrase I (CA-I) DMVKW0N MT DTT DMVKW0N MA Inhibitor DMVKW0N RN Carbonic anhydrase inhibitors. Interaction of the antitumor sulfamate EMD 486019 with twelve mammalian carbonic anhydrase isoforms: Kinetic and X-r... Bioorg Med Chem Lett. 2008 Aug 1;18(15):4282-6. DMVKW0N RU https://pubmed.ncbi.nlm.nih.gov/18640037 DMVKW0N DI DMVKW0N DMVKW0N DN Coumate DMVKW0N MI TTANPDJ DMVKW0N MN Carbonic anhydrase II (CA-II) DMVKW0N MT DTT DMVKW0N MA Inhibitor DMVKW0N RN Carbonic anhydrase inhibitors. Interaction of the antitumor sulfamate EMD 486019 with twelve mammalian carbonic anhydrase isoforms: Kinetic and X-r... Bioorg Med Chem Lett. 2008 Aug 1;18(15):4282-6. DMVKW0N RU https://pubmed.ncbi.nlm.nih.gov/18640037 DMVKW0N DI DMVKW0N DMVKW0N DN Coumate DMVKW0N MI TTZHA0O DMVKW0N MN Carbonic anhydrase IV (CA-IV) DMVKW0N MT DTT DMVKW0N MA Inhibitor DMVKW0N RN Carbonic anhydrase inhibitors. Interaction of the antitumor sulfamate EMD 486019 with twelve mammalian carbonic anhydrase isoforms: Kinetic and X-r... Bioorg Med Chem Lett. 2008 Aug 1;18(15):4282-6. DMVKW0N RU https://pubmed.ncbi.nlm.nih.gov/18640037 DMVKW0N DI DMVKW0N DMVKW0N DN Coumate DMVKW0N MI TT2LVK8 DMVKW0N MN Carbonic anhydrase IX (CA-IX) DMVKW0N MT DTT DMVKW0N MA Inhibitor DMVKW0N RN Carbonic anhydrase inhibitors. Interaction of the antitumor sulfamate EMD 486019 with twelve mammalian carbonic anhydrase isoforms: Kinetic and X-r... Bioorg Med Chem Lett. 2008 Aug 1;18(15):4282-6. DMVKW0N RU https://pubmed.ncbi.nlm.nih.gov/18640037 DMVKW0N DI DMVKW0N DMVKW0N DN Coumate DMVKW0N MI TTCFSPE DMVKW0N MN Carbonic anhydrase VI (CA-VI) DMVKW0N MT DTT DMVKW0N MA Inhibitor DMVKW0N RN Carbonic anhydrase inhibitors. Interaction of the antitumor sulfamate EMD 486019 with twelve mammalian carbonic anhydrase isoforms: Kinetic and X-r... Bioorg Med Chem Lett. 2008 Aug 1;18(15):4282-6. DMVKW0N RU https://pubmed.ncbi.nlm.nih.gov/18640037 DMVKW0N DI DMVKW0N DMVKW0N DN Coumate DMVKW0N MI TTSYM0R DMVKW0N MN Carbonic anhydrase XII (CA-XII) DMVKW0N MT DTT DMVKW0N MA Inhibitor DMVKW0N RN Carbonic anhydrase inhibitors. Interaction of the antitumor sulfamate EMD 486019 with twelve mammalian carbonic anhydrase isoforms: Kinetic and X-r... Bioorg Med Chem Lett. 2008 Aug 1;18(15):4282-6. DMVKW0N RU https://pubmed.ncbi.nlm.nih.gov/18640037 DMVKW0N DI DMVKW0N DMVKW0N DN Coumate DMVKW0N MI TTEYTKG DMVKW0N MN Carbonic anhydrase XIV (CA-XIV) DMVKW0N MT DTT DMVKW0N MA Inhibitor DMVKW0N RN Carbonic anhydrase inhibitors. Interaction of the antitumor sulfamate EMD 486019 with twelve mammalian carbonic anhydrase isoforms: Kinetic and X-r... Bioorg Med Chem Lett. 2008 Aug 1;18(15):4282-6. DMVKW0N RU https://pubmed.ncbi.nlm.nih.gov/18640037 DMVKW0N DI DMVKW0N DMVKW0N DN Coumate DMVKW0N MI TTHM0R1 DMVKW0N MN Steryl-sulfatase (STS) DMVKW0N MT DTT DMVKW0N MA Inhibitor DMVKW0N RN Highly potent first examples of dual aromatase-steroid sulfatase inhibitors based on a biphenyl template. J Med Chem. 2010 Mar 11;53(5):2155-70. DMVKW0N RU https://pubmed.ncbi.nlm.nih.gov/20148564 DM2K5VP DI DM2K5VP DM2K5VP DN Coxsackievirus A21 DM2K5VP MI TT5Z9WY DM2K5VP MN Complement decay-accelerating factor (CD55) DM2K5VP MT DTT DM2K5VP MA Inhibitor DM2K5VP RN Oncolytic Coxsackievirus A21 as a novel therapy for multiple myeloma. Br J Haematol. 2007 Apr;137(2):133-41. DM2K5VP RU https://pubmed.ncbi.nlm.nih.gov/17391493 DM8X5Q1 DI DM8X5Q1 DM8X5Q1 DN CP101 DM8X5Q1 MI TT9IK2Z DM8X5Q1 MN N-methyl-D-aspartate receptor (NMDAR) DM8X5Q1 MT DTT DM8X5Q1 MA Antagonist DM8X5Q1 RN The neuroprotective effect of the forebrain-selective NMDA antagonist CP101,606 upon focal ischemic brain damage caused by acute subdural hematoma in the rat. J Neurotrauma. 1997 Jun;14(6):409-17. DM8X5Q1 RU https://pubmed.ncbi.nlm.nih.gov/9219855 DMIU19E DI DMIU19E DMIU19E DN CP-101,606 DMIU19E MI TTN9D8E DMIU19E MN Glutamate receptor ionotropic NMDA 2B (NMDAR2B) DMIU19E MT DTT DMIU19E MA Antagonist DMIU19E RN NMDA receptors as targets for drug action in neuropathic pain. Eur J Pharmacol. 2001 Oct 19;429(1-3):71-8. DMIU19E RU https://pubmed.ncbi.nlm.nih.gov/11698028 DMSWLM5 DI DMSWLM5 DMSWLM5 DN CP-122721 DMSWLM5 MI DECB0K3 DMSWLM5 MN Cytochrome P450 2D6 (CYP2D6) DMSWLM5 MT DME DMSWLM5 MA Metabolism DMSWLM5 RN In vitro metabolism of CP-122,721 ((2S,3S)-2-phenyl-3-[(5-trifluoromethoxy-2-methoxy)benzylamino]piperidine), a non-peptide antagonist of the substance P receptor. Drug Metab Pharmacokinet. 2007 Oct;22(5):336-49. DMSWLM5 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=17965517 DMSWLM5 DI DMSWLM5 DMSWLM5 DN CP-122721 DMSWLM5 MI DE4LYSA DMSWLM5 MN Cytochrome P450 3A4 (CYP3A4) DMSWLM5 MT DME DMSWLM5 MA Metabolism DMSWLM5 RN In vitro metabolism of CP-122,721 ((2S,3S)-2-phenyl-3-[(5-trifluoromethoxy-2-methoxy)benzylamino]piperidine), a non-peptide antagonist of the substance P receptor. Drug Metab Pharmacokinet. 2007 Oct;22(5):336-49. DMSWLM5 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=17965517 DMSWLM5 DI DMSWLM5 DMSWLM5 DN CP-122721 DMSWLM5 MI DTUGYRD DMSWLM5 MN P-glycoprotein 1 (ABCB1) DMSWLM5 MT DTP DMSWLM5 MA Substrate DMSWLM5 RN P-glycoprotein efflux at the blood-brain barrier mediates differences in brain disposition and pharmacodynamics between two structurally related neurokinin-1 receptor antagonists. J Pharmacol Exp Ther. 2001 Sep;298(3):1252-9. DMSWLM5 RU http://www.ncbi.nlm.nih.gov/pubmed/11504828 DMSWLM5 DI DMSWLM5 DMSWLM5 DN CP-122721 DMSWLM5 MI TTZPO1L DMSWLM5 MN Substance-P receptor (TACR1) DMSWLM5 MT DTT DMSWLM5 MA Antagonist DMSWLM5 RN A review of drug options in age-related macular degeneration therapy and potential new agents. Expert Opin Pharmacother. 2006 Dec;7(17):2355-68. DMSWLM5 RU https://pubmed.ncbi.nlm.nih.gov/17109611 DMVO5DR DI DMVO5DR DMVO5DR DN CP-331684 DMVO5DR MI TTMXGCW DMVO5DR MN Adrenergic receptor beta-3 (ADRB3) DMVO5DR MT DTT DMVO5DR MA Agonist DMVO5DR RN CN patent application no. 1717230, Pharmaceutical composition comprising a beta-3-adrenoceptor agonist and a serotonin and/or norepinephrine reuptake inhibitor. DMVO5DR RU https://www.google.com/patents/CN1717230A?cl=en DMEYMTX DI DMEYMTX DMEYMTX DN CP-461 DMEYMTX MI TTJGW1Z DMEYMTX MN Phosphodiesterase 2A (PDE2A) DMEYMTX MT DTT DMEYMTX MA Inhibitor DMEYMTX RN Sulindac and its derivatives: a novel class of anticancer agents. Curr Opin Investig Drugs. 2001 May;2(5):677-83. DMEYMTX RU https://pubmed.ncbi.nlm.nih.gov/11569947 DMZEJLB DI DMZEJLB DMZEJLB DN CP-533536 DMZEJLB MI TT1ZAVI DMZEJLB MN Prostaglandin E2 receptor EP2 (PTGER2) DMZEJLB MT DTT DMZEJLB MA Agonist DMZEJLB RN Pfizer. Product Development Pipeline. March 31 2009. DMZEJLB RU http://media.pfizer.com/files/research/pipeline/2009_0331/pipeline_2009_0331.pdf DMX054A DI DMX054A DMX054A DN CP-547632 DMX054A MI TTUTJGQ DMX054A MN Vascular endothelial growth factor receptor 2 (KDR) DMX054A MT DTT DMX054A MA Inhibitor DMX054A RN A comparison of physicochemical property profiles of marketed oral drugs and orally bioavailable anti-cancer protein kinase inhibitors in clinical development. Curr Top Med Chem. 2007;7(14):1408-22. DMX054A RU https://pubmed.ncbi.nlm.nih.gov/17692029 DMKJFDM DI DMKJFDM DMKJFDM DN CP-601927 DMKJFDM MI TTL1ATN DMKJFDM MN Neuronal acetylcholine receptor alpha-4/beta-2 (CHRNA4/B2) DMKJFDM MT DTT DMKJFDM MA Modulator DMKJFDM RN Toxicity study in juvenile rats with the alpha4beta2 nicotinic acetylcholine receptor partial agonist CP-601,927. Birth Defects Res B Dev Reprod Toxicol. 2011 Aug;92(4):323-32. DMKJFDM RU https://pubmed.ncbi.nlm.nih.gov/21594972 DMUJ0W7 DI DMUJ0W7 DMUJ0W7 DN CP-724714 DMUJ0W7 MI DTI7UX6 DMUJ0W7 MN Breast cancer resistance protein (ABCG2) DMUJ0W7 MT DTP DMUJ0W7 MA Substrate DMUJ0W7 RN Multi-drug-resistance-reverting agents: 2-aryloxazole and 2-arylthiazole derivatives as potent BCRP or MRP1 inhibitors. ChemMedChem. 2009 Feb;4(2):188-95. DMUJ0W7 RU https://doi.org/10.1002/cmdc.200800329 DMUJ0W7 DI DMUJ0W7 DMUJ0W7 DN CP-724714 DMUJ0W7 MI TT6EO5L DMUJ0W7 MN Erbb2 tyrosine kinase receptor (HER2) DMUJ0W7 MT DTT DMUJ0W7 MA Inhibitor DMUJ0W7 RN A comparison of physicochemical property profiles of marketed oral drugs and orally bioavailable anti-cancer protein kinase inhibitors in clinical development. Curr Top Med Chem. 2007;7(14):1408-22. DMUJ0W7 RU https://pubmed.ncbi.nlm.nih.gov/17692029 DMT3ORQ DI DMT3ORQ DMT3ORQ DN CP-80794 DMT3ORQ MI TTB2MXP DMT3ORQ MN Angiotensinogenase renin (REN) DMT3ORQ MT DTT DMT3ORQ MA Inhibitor DMT3ORQ RN Synergistic effect on reduction in blood pressure with coadministration of the renin inhibitor, CP-80,794, and the angiotensin converting enzyme inhibitor, captopril. J Cardiovasc Pharmacol. 1992 Jul;20(1):75-82. DMT3ORQ RU https://pubmed.ncbi.nlm.nih.gov/1383634 DM6MUCX DI DM6MUCX DM6MUCX DN CpG-10101 DM6MUCX MI TTSHG0T DM6MUCX MN Toll-like receptor 9 (TLR9) DM6MUCX MT DTT DM6MUCX MA Agonist DM6MUCX RN Safety, pharmacokinetics and immune effects in normal volunteers of CPG 10101 (ACTILON), an investigational synthetic toll-like receptor 9 agonist. Antivir Ther. 2007;12(5):741-51. DM6MUCX RU https://pubmed.ncbi.nlm.nih.gov/17713157 DMK9NQI DI DMK9NQI DMK9NQI DN CPP-115 DMK9NQI MI TTT2LD9 DMK9NQI MN GABA transaminase (ABAT) DMK9NQI MT DTT DMK9NQI MA Inhibitor DMK9NQI RN Clinical pipeline report, company report or official report of Catalyst Pharma. DMK9NQI RU http://ir.catalystpharma.com/releasedetail.cfm?ReleaseID=633588 DMK7DFM DI DMK7DFM DMK7DFM DN CPX-POM DMK7DFM MI TTX09M4 DMK7DFM MN Ribonucleotide reductase (RIR) DMK7DFM MT DTT DMK7DFM MA Inhibitor DMK7DFM RN Preclinical Pharmacokinetics of Fosciclopirox, a Novel Treatment of Urothelial Cancers, in Rats and Dogs. J Pharmacol Exp Ther. 2019 Aug;370(2):148-159. DMK7DFM RU https://pubmed.ncbi.nlm.nih.gov/31113837 DMHJEZS DI DMHJEZS DMHJEZS DN CR-3294 DMHJEZS MI TTF10I9 DMHJEZS MN Nitric-oxide synthase inducible (NOS2) DMHJEZS MT DTT DMHJEZS MA Inhibitor DMHJEZS RN Efficacy of CR3294, a new benzamidine derivative, in the prevention of 5-fluorouracil-induced gastrointestinal mucositis and diarrhea in mice. Cancer Chemother Pharmacol. 2010 October; 66(5): 819-827. DMHJEZS RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2926937/ DMNC1AF DI DMNC1AF DMNC1AF DN CR-665 DMNC1AF MI TTQW87Y DMNC1AF MN Opioid receptor kappa (OPRK1) DMNC1AF MT DTT DMNC1AF MA Agonist DMNC1AF RN Analgesic efficacy of peripheral kappa-opioid receptor agonist CR665 compared to oxycodone in a multi-modal, multi-tissue experimental human pain model: selective effect on visceral pain. Anesthesiology. 2009 Sep;111(3):616-24. DMNC1AF RU https://pubmed.ncbi.nlm.nih.gov/19672186 DMQ47U6 DI DMQ47U6 DMQ47U6 DN CR8020 DMQ47U6 MI TTF4CAM DMQ47U6 MN Influenza Hemagglutinin (Influ HA) DMQ47U6 MT DTT DMQ47U6 RN Characterization of a broadly neutralizing monoclonal antibody that targets the fusion domain of group 2 influenza A virus hemagglutinin. J Virol. 2014 Dec;88(23):13580-92. DMQ47U6 RU https://pubmed.ncbi.nlm.nih.gov/25210195 DMO1ZGX DI DMO1ZGX DMO1ZGX DN CRILVASTATIN DMO1ZGX MI TTPADOQ DMO1ZGX MN HMG-CoA reductase (HMGCR) DMO1ZGX MT DTT DMO1ZGX MA Inhibitor DMO1ZGX RN Differences in hypolipidaemic effects of two statins on Hep G2 cells or human hepatocytes in primary culture. Br J Pharmacol. 1996 Aug;118(7):1862-8. DMO1ZGX RU https://pubmed.ncbi.nlm.nih.gov/8842455 DMQUWXY DI DMQUWXY DMQUWXY DN CRLX101 DMQUWXY MI TTGTQHC DMQUWXY MN DNA topoisomerase I (TOP1) DMQUWXY MT DTT DMQUWXY MA Modulator DMQUWXY RN Company report (Ceruleanrx) DMQUWXY RU http://ceruleanrx.com/platform-pipeline/crlx101.php DM85WID DI DM85WID DM85WID DN Crobenetine DM85WID MI TTRK8B9 DM85WID MN Sodium channel unspecific (NaC) DM85WID MT DTT DM85WID MA Antagonist DM85WID RN Analgesic activity of a novel use-dependent sodium channel blocker, crobenetine, in mono-arthritic rats. Br J Pharmacol. 2001 Dec;134(8):1742-8. DM85WID RU https://pubmed.ncbi.nlm.nih.gov/11739251 DM129T7 DI DM129T7 DM129T7 DN CROMOGLYCATE LISETIL HYDROCHLORIDE DM129T7 MI TTE87WJ DM129T7 MN Calcium-activated potassium channel KCa1.1 (KCNMA1) DM129T7 MT DTT DM129T7 MA Modulator DM129T7 RN The significance of chloride in the inhibitory action of disodium cromoglycate on immunologically-stimulated rat peritoneal mast cells. Biochim Biophys Acta. 2011 Sep;1810(9):867-74. DM129T7 RU https://pubmed.ncbi.nlm.nih.gov/21635937 DMXU5LZ DI DMXU5LZ DMXU5LZ DN CRS-207 DMXU5LZ MI TT4RXME DMXU5LZ MN Mesothelin (MSLN) DMXU5LZ MT DTT DMXU5LZ RN Safety and survival with GVAX pancreas prime and Listeria Monocytogenes-expressing mesothelin (CRS-207) boost vaccines for metastatic pancreatic cancer. J Clin Oncol. 2015 Apr 20;33(12):1325-33. DMXU5LZ RU https://pubmed.ncbi.nlm.nih.gov/25584002 DM16IMT DI DM16IMT DM16IMT DN CRYPTOPHYCIN 52 DM16IMT MI TTML2WA DM16IMT MN Tubulin (TUB) DM16IMT MT DTT DM16IMT MA Inhibitor DM16IMT RN Phase 2 study of cryptophycin 52 (LY355703) in patients previously treated with platinum based chemotherapy for advanced non-small cell lung cancer. Lung Cancer. 2003 Feb;39(2):197-9. DM16IMT RU https://pubmed.ncbi.nlm.nih.gov/12581573 DMZCG91 DI DMZCG91 DMZCG91 DN CSL-112 DMZCG91 MI TT7GN3U DMZCG91 MN Apolipoprotein A-I (APOA1) DMZCG91 MT DTT DMZCG91 MA Modulator DMZCG91 RN CER-001, a HDL-mimetic, stimulates the reverse lipid transport and atherosclerosis regression in high cholesterol diet-fed LDL-receptor deficient mice. Atherosclerosis. 2014 Jan;232(1):110-8. DMZCG91 RU https://pubmed.ncbi.nlm.nih.gov/24401224 DMQXL1T DI DMQXL1T DMQXL1T DN CT 327 DMQXL1T MI TTTDVOJ DMQXL1T MN Tropomyosin-related kinase A (TrkA) DMQXL1T MT DTT DMQXL1T MA Inhibitor DMQXL1T RN Topical TrkA Kinase Inhibitor CT327 is an Effective, Novel Therapy for the Treatment of Pruritus due to Psoriasis: Results from Experimental Studies, and Efficacy and Safety of CT327 in a Phase 2b Clinical Trial in Patients with Psoriasis. Acta Derm Venereol. 2015 May;95(5):542-8. DMQXL1T RU https://pubmed.ncbi.nlm.nih.gov/25594427 DMBRKZ7 DI DMBRKZ7 DMBRKZ7 DN CT1812 DMBRKZ7 MI TT9NXW4 DMBRKZ7 MN Sigma intracellular receptor 2 (TMEM97) DMBRKZ7 MT DTT DMBRKZ7 MA Antagonist DMBRKZ7 RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMBRKZ7 RU http://phrma-docs.phrma.org/files/dmfile/MID_Neurological-Disorders-Drug-List_2018.pdf DMSGYNP DI DMSGYNP DMSGYNP DN CTK0H-9987 DMSGYNP MI DEEHWOG DMSGYNP MN Azoreductase (azoR) DMSGYNP MT DME DMSGYNP MA Metabolism DMSGYNP RN The role of the gut flora in the metabolism of prontosil and neoprontosil in the rat. Xenobiotica. 1971 Mar;1(2):143-56. DMSGYNP RU https://pubmed.ncbi.nlm.nih.gov/5173017 DMSGYNP DI DMSGYNP DMSGYNP DN CTK0H-9987 DMSGYNP MI DEPF49Q DMSGYNP MN Azoreductase (azoR) DMSGYNP MT DME DMSGYNP MA Metabolism DMSGYNP RN Developing a metagenomic view of xenobiotic metabolism. Pharmacol Res. 2013 Mar;69(1):21-31. DMSGYNP RU https://pubmed.ncbi.nlm.nih.gov/22902524 DMSGYNP DI DMSGYNP DMSGYNP DN CTK0H-9987 DMSGYNP MI DEMW0RC DMSGYNP MN Azoreductase (azoR) DMSGYNP MT DME DMSGYNP MA Metabolism DMSGYNP RN Developing a metagenomic view of xenobiotic metabolism. Pharmacol Res. 2013 Mar;69(1):21-31. DMSGYNP RU https://pubmed.ncbi.nlm.nih.gov/22902524 DMSGYNP DI DMSGYNP DMSGYNP DN CTK0H-9987 DMSGYNP MI DETP059 DMSGYNP MN Azoreductase (azoR) DMSGYNP MT DME DMSGYNP MA Metabolism DMSGYNP RN Developing a metagenomic view of xenobiotic metabolism. Pharmacol Res. 2013 Mar;69(1):21-31. DMSGYNP RU https://pubmed.ncbi.nlm.nih.gov/22902524 DMMPC6W DI DMMPC6W DMMPC6W DN CTL019 DMMPC6W MI TTW640A DMMPC6W MN B-lymphocyte surface antigen B4 (CD19) DMMPC6W MT DTT DMMPC6W MA CAR-T-Cell-Therapy DMMPC6W RN ClinicalTrials.gov (NCT02445248) Study of Efficacy and Safety of CTL019 in Adult DLBCL Patients. U.S. National Institutes of Health. DMMPC6W RU https://clinicaltrials.gov/ct2/show/NCT02445248 DM3SYOK DI DM3SYOK DM3SYOK DN CTP-543 DM3SYOK MI TT6DM01 DM3SYOK MN Janus kinase 1 (JAK-1) DM3SYOK MT DTT DM3SYOK MA Inhibitor DM3SYOK RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DM3SYOK RU http://phrma-docs.phrma.org/files/dmfile/medicines-in-development-drug-list-autoimmune-diseases.pdf DMBT46Y DI DMBT46Y DMBT46Y DN CTP-543 DMBT46Y MI TT6DM01 DMBT46Y MN Janus kinase 1 (JAK-1) DMBT46Y MT DTT DMBT46Y MA Inhibitor DMBT46Y RN Clinical pipeline report, company report or official report of Concert Pharmaceuticals. DMBT46Y RU https://www.concertpharma.com/product-pipeline/ctp-543/ DM3SYOK DI DM3SYOK DM3SYOK DN CTP-543 DM3SYOK MI TTRMX3V DM3SYOK MN Janus kinase 2 (JAK-2) DM3SYOK MT DTT DM3SYOK MA Inhibitor DM3SYOK RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DM3SYOK RU http://phrma-docs.phrma.org/files/dmfile/medicines-in-development-drug-list-autoimmune-diseases.pdf DMBT46Y DI DMBT46Y DMBT46Y DN CTP-543 DMBT46Y MI TTRMX3V DMBT46Y MN Janus kinase 2 (JAK-2) DMBT46Y MT DTT DMBT46Y MA Inhibitor DMBT46Y RN Clinical pipeline report, company report or official report of Concert Pharmaceuticals. DMBT46Y RU https://www.concertpharma.com/product-pipeline/ctp-543/ DMYPXQ2 DI DMYPXQ2 DMYPXQ2 DN CVBT-141H DMYPXQ2 MI TTMY81X DMYPXQ2 MN Heparin-binding growth factor 1 (FGF1) DMYPXQ2 MT DTT DMYPXQ2 MA Modulator DMYPXQ2 RN Clinical pipeline report, company report or official report of CVBT. DMYPXQ2 RU http://cvbt.com/index.php?pr=Severe_CHD DMCN9GX DI DMCN9GX DMCN9GX DN CVX-045 DMCN9GX MI TTKI0H1 DMCN9GX MN Thrombospondin-1 (THBS1) DMCN9GX MT DTT DMCN9GX MA Agonist DMCN9GX RN Antitumor efficacy of a thrombospondin 1 mimetic CovX-body. Transl Oncol. 2011 Aug;4(4):249-57. DMCN9GX RU https://pubmed.ncbi.nlm.nih.gov/21804921 DMVZT2I DI DMVZT2I DMVZT2I DN CX-072 DMVZT2I MI TT8ZLTI DMVZT2I MN Programmed cell death 1 ligand 1 (PD-L1) DMVZT2I MT DTT DMVZT2I MA Inhibitor DMVZT2I RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMVZT2I RU http://phrma-docs.phrma.org/files/dmfile/MID_Immuno-Oncology-2017_Drug-List1.pdf DMS2WB5 DI DMS2WB5 DMS2WB5 DN CX157 DMS2WB5 MI TT3WG5C DMS2WB5 MN Monoamine oxidase type A (MAO-A) DMS2WB5 MT DTT DMS2WB5 MA Inhibitor DMS2WB5 RN Reversible inhibitors of monoamine oxidase-A (RIMAs): robust, reversible inhibition of human brain MAO-A by CX157. Neuropsychopharmacology. 2010 Feb;35(3):623-31. DMS2WB5 RU https://pubmed.ncbi.nlm.nih.gov/19890267 DMJD7H4 DI DMJD7H4 DMJD7H4 DN CX-1739 DMJD7H4 MI TTAN6JD DMJD7H4 MN Glutamate receptor AMPA (GRIA) DMJD7H4 MT DTT DMJD7H4 MA Agonist DMJD7H4 RN AMPAKINE enhancement of social interaction in the BTBR mouse model of autism. Neuropharmacology. 2013 Jan;64:268-82. DMJD7H4 RU https://pubmed.ncbi.nlm.nih.gov/22801296 DMA5D6T DI DMA5D6T DMA5D6T DN CX1789 DMA5D6T MI TTAN6JD DMA5D6T MN Glutamate receptor AMPA (GRIA) DMA5D6T MT DTT DMA5D6T MA Agonist DMA5D6T RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMA5D6T RU http://phrma-docs.phrma.org/files/dmfile/MID_Neurological-Disorders-Drug-List_2018.pdf DMU62I8 DI DMU62I8 DMU62I8 DN CX2009 DMU62I8 MI TT2AFT6 DMU62I8 MN Activated leukocyte cell adhesionmolecule (ALCAM) DMU62I8 MT DTT DMU62I8 RN Clinical pipeline report, company report or official report of CytomX Therapeutics. DMU62I8 RU https://cytomx.com/pipeline/ DMWE7B9 DI DMWE7B9 DMWE7B9 DN CX-4945 DMWE7B9 MI TTZ5NI7 DMWE7B9 MN Casein kinase II (CSNK2) DMWE7B9 MT DTT DMWE7B9 MA Modulator DMWE7B9 RN CX-4945, a selective inhibitor of casein kinase-2 (CK2), exhibits anti-tumor activity in hematologic malignancies including enhanced activity in chronic lymphocytic leukemia when combined with fludarabine and inhibitors of the B-cell receptor pathway. Leukemia. 2013 Oct;27(10):2094-6. DMWE7B9 RU https://pubmed.ncbi.nlm.nih.gov/23900138 DMWE7B9 DI DMWE7B9 DMWE7B9 DN CX-4945 DMWE7B9 MI TTER6YH DMWE7B9 MN Casein kinase II alpha (CSNK2A1) DMWE7B9 MT DTT DMWE7B9 MA Inhibitor DMWE7B9 RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMWE7B9 RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DMM65W1 DI DMM65W1 DMM65W1 DN CX-717 DMM65W1 MI TTAN6JD DMM65W1 MN Glutamate receptor AMPA (GRIA) DMM65W1 MT DTT DMM65W1 MA Modulator DMM65W1 RN Acute sleep deprivation: the effects of the AMPAKINE compound CX717 on human cognitive performance, alertness and recovery sleep. J Psychopharmacol. 2012 Aug;26(8):1047-57. DMM65W1 RU https://pubmed.ncbi.nlm.nih.gov/21940760 DM3GEHC DI DM3GEHC DM3GEHC DN CX-8998 DM3GEHC MI TTT6NKW DM3GEHC MN Voltage-gated T-type calcium channel (T-CaC) DM3GEHC MT DTT DM3GEHC MA Modulator DM3GEHC RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DM3GEHC RU http://phrma-docs.phrma.org/files/dmfile/MID_Neurological-Disorders-Drug-List_2018.pdf DMM7Z6K DI DMM7Z6K DMM7Z6K DN CXA10 DMM7Z6K MI TT3Z6Y9 DMM7Z6K MN Cysteines of Keap1 (KEAP1 Cysteines) DMM7Z6K MT DTT DMM7Z6K MA Inactivator DMM7Z6K RN The Keap1-Nrf2 pathway: promising therapeutic target to counteract ROS-mediated damage in cancers and neurodegenerative diseases. Biophys Rev. 2017 Feb;9(1):41-56. DMM7Z6K RU https://pubmed.ncbi.nlm.nih.gov/28510041 DMM7Z6K DI DMM7Z6K DMM7Z6K DN CXA10 DMM7Z6K MI TTA6ZN2 DMM7Z6K MN Nuclear factor erythroid 2-related factor 2 (Nrf2) DMM7Z6K MT DTT DMM7Z6K MA Activator DMM7Z6K RN The Keap1-Nrf2 pathway: promising therapeutic target to counteract ROS-mediated damage in cancers and neurodegenerative diseases. Biophys Rev. 2017 Feb;9(1):41-56. DMM7Z6K RU https://pubmed.ncbi.nlm.nih.gov/28510041 DM3JFZ2 DI DM3JFZ2 DM3JFZ2 DN CXL DM3JFZ2 MI TTHI19T DM3JFZ2 MN Staphylococcus Beta-lactamase (Stap-coc blaZ) DM3JFZ2 MT DTT DM3JFZ2 MA Modulator DM3JFZ2 RN Beta-Lactam Antibiotics Renaissance. Antibiotics. 2014, 3(2), 193-215. DM3JFZ2 RU http://www.mdpi.com/2079-6382/3/2/193 DMXR8WN DI DMXR8WN DMXR8WN DN CYCLOPLATAM DMXR8WN MI TTYVX59 DMXR8WN MN Protein kinase C (PRKC) DMXR8WN MT DTT DMXR8WN MA Inhibitor DMXR8WN RN Effect of anti-tumor agents cisplatin and cycloplatam on membrane protein kinase C activity in murine T-lymphocytes. Biokhimiia. 1996 Oct;61(10):1866-73. DMXR8WN RU https://pubmed.ncbi.nlm.nih.gov/9011234 DM0DT45 DI DM0DT45 DM0DT45 DN CYSTEMUSTINE DM0DT45 MI TTUTN1I DM0DT45 MN Human Deoxyribonucleic acid (hDNA) DM0DT45 MT DTT DM0DT45 MA Binder DM0DT45 RN A new O6-alkylguanine-DNA alkyltransferase inhibitor associated with a nitrosourea (cystemustine) validates a strategy of melanoma-targeted therapy in murine B16 and human-resistant M4Beu melanoma xenograft models. J Pharmacol Exp Ther. 2008 Jul;326(1):171-7. DM0DT45 RU https://pubmed.ncbi.nlm.nih.gov/18411412 DMMWIHC DI DMMWIHC DMMWIHC DN CYT 99007 DMMWIHC MI TTAWI51 DMMWIHC MN Interleukin 7 receptor alpha (IL7R) DMMWIHC MT DTT DMMWIHC MA Binder DMMWIHC RN Perspectives on interleukin-7 therapy in HIV infection. Curr Opin HIV AIDS. 2007 May;2(3):228-33. DMMWIHC RU https://pubmed.ncbi.nlm.nih.gov/19372891 DM4LJH8 DI DM4LJH8 DM4LJH8 DN CYT003 DM4LJH8 MI TTSHG0T DM4LJH8 MN Toll-like receptor 9 (TLR9) DM4LJH8 MT DTT DM4LJH8 MA Agonist DM4LJH8 RN CYT003, a TLR9 agonist, in persistent allergic asthma - a randomized placebo-controlled Phase 2b study. Allergy. 2015 Sep;70(9):1160-8. DM4LJH8 RU https://pubmed.ncbi.nlm.nih.gov/26042362 DMIRSWE DI DMIRSWE DMIRSWE DN CYT-006-AngQb DMIRSWE MI TTGN1ZA DMIRSWE MN Angiotensin II receptor (AGTR) DMIRSWE MT DTT DMIRSWE RN CYT-006-AngQb, a vaccine against angiotensin II for the potential treatment of hypertension. Curr Opin Investig Drugs. 2009 Mar;10(3):269-75. DMIRSWE RU https://pubmed.ncbi.nlm.nih.gov/19333885 DMUDMHA DI DMUDMHA DMUDMHA DN CZEN-002 DMUDMHA MI TTSXVID DMUDMHA MN Nuclear factor NF-kappa-B (NFKB) DMUDMHA MT DTT DMUDMHA MA Modulator DMUDMHA RN US patent application no. US20100278784 A1. DMUDMHA RU https://www.google.com.ar/patents/US20100278784 DMP6MH9 DI DMP6MH9 DMP6MH9 DN DA-8031 DMP6MH9 MI TT3ROYC DMP6MH9 MN Serotonin transporter (SERT) DMP6MH9 MT DTT DMP6MH9 MA Inhibitor DMP6MH9 RN Effect of DA-8031, a novel oral compound for premature ejaculation, on male rat sexual behavior. Int J Urol. 2014 Mar;21(3):325-9. DMP6MH9 RU https://pubmed.ncbi.nlm.nih.gov/23968141 DMACTBM DI DMACTBM DMACTBM DN DAC-060 DMACTBM MI TTBH0VX DMACTBM MN Histone deacetylase (HDAC) DMACTBM MT DTT DMACTBM MA Inhibitor DMACTBM RN Targeted cancer therapy: giving histone deacetylase inhibitors all they need to succeed. Correction in: volume 4 on page 1369. DMACTBM RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3341130/ DM2U45Q DI DM2U45Q DM2U45Q DN Danegaptide DM2U45Q MI TTJO6E9 DM2U45Q MN Gap junction protein (GJP) DM2U45Q MT DTT DM2U45Q MA Modulator DM2U45Q RN The gap junction modifier, GAP-134 [(2S,4R)-1-(2-aminoacetyl)-4-benzamido-pyrrolidine-2-carboxylic acid], improves conduction and reduces atrial fibrillation/flutter in the canine sterile pericarditis model. J Pharmacol Exp Ther. 2009 Jun;329(3):1127-33. DM2U45Q RU https://pubmed.ncbi.nlm.nih.gov/19252062 DM20MDU DI DM20MDU DM20MDU DN Danoprevir DM20MDU MI DE4LYSA DM20MDU MN Cytochrome P450 3A4 (CYP3A4) DM20MDU MT DME DM20MDU MA Metabolism DM20MDU RN Comprehensive Medicinal Chemistry III. Page: 569. DM20MDU RU https://books.google.fr/books?id=iZHUDQAAQBAJ&pg=RA1-PA569&lpg=RA1-PA569&dq=Danoprevir+metabolizing+enzyme+metabolize&source=bl&ots=PaQ6yPgIDJ&sig=ACfU3U1Rask-Lef8fItwvzwnqUH9ud6e2Q&hl=zh-CN&sa=X&ved=2ahUKEwi8oo2mxrfnAhUQyxoKHV0GBtAQ6AEwCHoECAsQAQ DM20MDU DI DM20MDU DM20MDU DN Danoprevir DM20MDU MI TT5FNQT DM20MDU MN Human immunodeficiency virus Protease (HIV PR) DM20MDU MT DTT DM20MDU MA Inhibitor DM20MDU RN 2011 Pipeline of InterMune. DM20MDU RU http://www.intermune.com/pipeline DM20MDU DI DM20MDU DM20MDU DN Danoprevir DM20MDU MI DT3D8F0 DM20MDU MN Organic anion transporting polypeptide 1B1 (SLCO1B1) DM20MDU MT DTP DM20MDU MA Substrate DM20MDU RN FDA Drug Development and Drug Interactions DM20MDU RU https://www.fda.gov/drugs/developmentapprovalprocess/developmentresources/druginteractionslabeling/ucm093664.htm#table3-2 DM20MDU DI DM20MDU DM20MDU DN Danoprevir DM20MDU MI DT9C1TS DM20MDU MN Organic anion transporting polypeptide 1B3 (SLCO1B3) DM20MDU MT DTP DM20MDU MA Substrate DM20MDU RN FDA Drug Development and Drug Interactions DM20MDU RU https://www.fda.gov/drugs/developmentapprovalprocess/developmentresources/druginteractionslabeling/ucm093664.htm#table3-2 DM7IH48 DI DM7IH48 DM7IH48 DN Dapansutrile DM7IH48 MI TT4EN8X DM7IH48 MN Caterpiller protein 1.1 (NLRP3) DM7IH48 MT DTT DM7IH48 MA Inhibitor DM7IH48 RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DM7IH48 RU http://phrma-docs.phrma.org/files/dmfile/MID_Neurological-Disorders-Drug-List_2018.pdf DMIYFWA DI DMIYFWA DMIYFWA DN Dapirolizumab pegol DMIYFWA MI TTIJP3Q DMIYFWA MN TNF related activation protein (CD40LG) DMIYFWA MT DTT DMIYFWA MA Inhibitor DMIYFWA RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMIYFWA RU http://phrma-docs.phrma.org/files/dmfile/medicines-in-development-drug-list-autoimmune-diseases.pdf DMR5J6K DI DMR5J6K DMR5J6K DN DAPITANT DMR5J6K MI TTZPO1L DMR5J6K MN Substance-P receptor (TACR1) DMR5J6K MT DTT DMR5J6K MA Antagonist DMR5J6K RN Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800004225) DMR5J6K RU http://adisinsight.springer.com/drugs/800004225 DMCU74R DI DMCU74R DMCU74R DN Daporinad DMCU74R MI TTD1WIG DMCU74R MN Nicotinamide phosphoribosyltransferase (NAMPT) DMCU74R MT DTT DMCU74R MA Inhibitor DMCU74R RN Anticancer agent CHS-828 inhibits cellular synthesis of NAD. Biochem Biophys Res Commun. 2008 Mar 21;367(4):799-804. DMCU74R RU https://pubmed.ncbi.nlm.nih.gov/18201551 DM0Y8JP DI DM0Y8JP DM0Y8JP DN DAS-181 DM0Y8JP MI TT50QJ3 DM0Y8JP MN Influenza Neuraminidase (Influ NA) DM0Y8JP MT DTT DM0Y8JP MA Inhibitor DM0Y8JP RN Inhibition of neuraminidase inhibitor-resistant influenza virus by DAS181, a novel sialidase fusion protein. PLoS One. 2009 Nov 6;4(11):e7838. DM0Y8JP RU https://pubmed.ncbi.nlm.nih.gov/19893749 DMM3BPL DI DMM3BPL DMM3BPL DN DAS-431 DMM3BPL MI TTZFYLI DMM3BPL MN Dopamine D1 receptor (D1R) DMM3BPL MT DTT DMM3BPL MA Agonist DMM3BPL RN Adrogolide HCl (ABT-431; DAS-431), a prodrug of the dopamine D1 receptor agonist, A-86929: preclinical pharmacology and clinical data. CNS Drug Rev. 2001 Fall;7(3):305-16. DMM3BPL RU https://pubmed.ncbi.nlm.nih.gov/11607045 DM7JV4O DI DM7JV4O DM7JV4O DN DB-041901 DM7JV4O MI DEOHI3U DM7JV4O MN Beta-glucosidase (bglA) DM7JV4O MT DME DM7JV4O MA Metabolism DM7JV4O RN Gut microbiota-mediated drug-antibiotic interactions. Drug Metab Dispos. 2015 Oct;43(10):1581-9. DM7JV4O RU https://pubmed.ncbi.nlm.nih.gov/25926432 DMQRCX5 DI DMQRCX5 DMQRCX5 DN DCDS-4501A DMQRCX5 MI TTBN5I7 DMQRCX5 MN B-cell-specific glycoprotein B29 (CD79B) DMQRCX5 MT DTT DMQRCX5 RN Marine-Sourced Anti-Cancer and Cancer Pain Control Agents in Clinical and Late Preclinical Development. Mar Drugs. 2014 January; 12(1): 255-278. DMQRCX5 RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3917273/ DMCHWX1 DI DMCHWX1 DMCHWX1 DN DCR-PHXC DMCHWX1 MI TTW76JE DMCHWX1 MN LDHA messenger RNA (LDHA mRNA) DMCHWX1 MT DTT DMCHWX1 MA Inhibitor DMCHWX1 RN Hepatic Lactate Dehydrogenase A: An RNA Interference Target for the Treatment of All Known Types of Primary Hyperoxaluria. Kidney Int Rep. 2021 Feb 3;6(4):1088-1098. DMCHWX1 RU https://pubmed.ncbi.nlm.nih.gov/33912759 DM9REBL DI DM9REBL DM9REBL DN DDP-225 DM9REBL MI TTNXLKE DM9REBL MN 5-HT 3 receptor (5HT3R) DM9REBL MT DTT DM9REBL MA Modulator DM9REBL RN Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41. DM9REBL RU https://www.ncbi.nlm.nih.gov/pubmed/15950434 DM5XT3G DI DM5XT3G DM5XT3G DN DE-098 DM5XT3G MI TTF0RCZ DM5XT3G MN Apoptosis mediating surface antigen FAS (FAS) DM5XT3G MT DTT DM5XT3G RN ARG098, a novel anti-human Fas antibody, suppresses synovial hyperplasia and prevents cartilage destruction in a severe combined immunodeficient-HuRAg mouse model. BMC Musculoskeletal Disorders 2010,11:221. DM5XT3G RU http://www.biomedcentral.com/1471-2474/11/221 DMCQL5I DI DMCQL5I DMCQL5I DN DE-110 DMCQL5I MI TTYRL6O DMCQL5I MN Glucocorticoid receptor (NR3C1) DMCQL5I MT DTT DMCQL5I MA Agonist DMCQL5I RN Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800031667) DMCQL5I RU http://adisinsight.springer.com/drugs/800031667 DMZW50O DI DMZW50O DMZW50O DN Debio 1347 DMZW50O MI TT0LF7H DMZW50O MN Fibroblast growth factor receptor (FGFR) DMZW50O MT DTT DMZW50O MA Modulator DMZW50O RN The fibroblast growth factor receptor genetic status as a potential predictor of the sensitivity to CH5183284/Debio 1347, a novel selective FGFR inhibitor. Mol Cancer Ther. 2014 Nov;13(11):2547-58. DMZW50O RU https://pubmed.ncbi.nlm.nih.gov/25169980 DMZW50O DI DMZW50O DMZW50O DN Debio 1347 DMZW50O MI TTRLW2X DMZW50O MN Fibroblast growth factor receptor 1 (FGFR1) DMZW50O MT DTT DMZW50O MA Inhibitor DMZW50O RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMZW50O RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DMZW50O DI DMZW50O DMZW50O DN Debio 1347 DMZW50O MI TTGJVQM DMZW50O MN Fibroblast growth factor receptor 2 (FGFR2) DMZW50O MT DTT DMZW50O MA Inhibitor DMZW50O RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMZW50O RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DMZW50O DI DMZW50O DMZW50O DN Debio 1347 DMZW50O MI TTST7KB DMZW50O MN Fibroblast growth factor receptor 3 (FGFR3) DMZW50O MT DTT DMZW50O MA Inhibitor DMZW50O RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMZW50O RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DM1H7UK DI DM1H7UK DM1H7UK DN Dectrekumab DM1H7UK MI TT0GVCH DM1H7UK MN Interleukin-13 (IL13) DM1H7UK MT DTT DM1H7UK MA Inhibitor DM1H7UK RN Intravenous anti-IL-13 mAb QAX576 for the treatment of eosinophilic esophagitis. J Allergy Clin Immunol. 2015 Feb;135(2):500-7. DM1H7UK RU https://pubmed.ncbi.nlm.nih.gov/25226850 DMX4DQH DI DMX4DQH DMX4DQH DN Delanzomib DMX4DQH MI TTU7ZMG DMX4DQH MN Proteasome (PS) DMX4DQH MT DTT DMX4DQH MA Modulator DMX4DQH RN Novel, orally active, proteasome inhibitor, delanzomib (CEP-18770), ameliorates disease symptoms and glomerulonephritis in two preclinical mouse models of SLE. Int Immunopharmacol. 2012 Jan;12(1):257-70. DMX4DQH RU https://pubmed.ncbi.nlm.nih.gov/22178195 DMS2WIN DI DMS2WIN DMS2WIN DN Delphinidin DMS2WIN MI TTUTJGQ DMS2WIN MN Vascular endothelial growth factor receptor 2 (KDR) DMS2WIN MT DTT DMS2WIN MA Modulator DMS2WIN RN Delphinidin, a dietary anthocyanidin, inhibits vascular endothelial growth factor receptor-2 phosphorylation. Carcinogenesis. 2006 May;27(5):989-96. DMS2WIN RU https://pubmed.ncbi.nlm.nih.gov/16308314 DM5CB8U DI DM5CB8U DM5CB8U DN DELTIBANT DM5CB8U MI TTGY8IW DM5CB8U MN B2 bradykinin receptor (BDKRB2) DM5CB8U MT DTT DM5CB8U MA Modulator DM5CB8U RN CP-0127, a novel potent bradykinin antagonist, increases survival in rat and rabbit models of endotoxin shock. Agents Actions Suppl. 1992;38 ( Pt 3):413-20. DM5CB8U RU https://pubmed.ncbi.nlm.nih.gov/1462875 DML4PMG DI DML4PMG DML4PMG DN Dendritic cell vaccine DML4PMG MI TTUJFD0 DML4PMG MN Telomerase reverse transcriptase (TERT) DML4PMG MT DTT DML4PMG RN In vitro activation of cytotoxic T-lymphocytes by hTERT-pulsed dendritic cells. J Immunotoxicol. 2009 Dec;6(4):243-8. DML4PMG RU https://pubmed.ncbi.nlm.nih.gov/19908943 DM7GPMB DI DM7GPMB DM7GPMB DN Depatuxizumab DM7GPMB MI TTGKNB4 DM7GPMB MN Epidermal growth factor receptor (EGFR) DM7GPMB MT DTT DM7GPMB MA Antagonist DM7GPMB RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DM7GPMB RU http://phrma-docs.phrma.org/files/dmfile/MID_Immuno-Oncology-2017_Drug-List1.pdf DMH96JW DI DMH96JW DMH96JW DN Dersalazine DMH96JW MI TTQL5VC DMH96JW MN Platelet-activating factor receptor (PTAFR) DMH96JW MT DTT DMH96JW MA Inhibitor DMH96JW RN The intestinal anti-inflammatory effect of dersalazine sodium is related to a down-regulation in IL-17 production in experimental models of rodent colitis. Br J Pharmacol. 2012 February; 165(3): 729-740. DMH96JW RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3315044/ DM63P1W DI DM63P1W DM63P1W DN Descartes-08 DM63P1W MI TTZ3P4W DM63P1W MN B-cell maturation protein (TNFRSF17) DM63P1W MT DTT DM63P1W MA CAR-T-Cell-Therapy DM63P1W RN ClinicalTrials.gov (NCT03448978) Autologous CD8+ T-cells Expressing an Anti-BCMA CAR in Patients With Myeloma DM63P1W RU https://clinicaltrials.gov/ct2/show/NCT03448978 DM1UO4S DI DM1UO4S DM1UO4S DN Descartes-11 DM1UO4S MI TTZ3P4W DM1UO4S MN B-cell maturation protein (TNFRSF17) DM1UO4S MT DTT DM1UO4S RN Clinical pipeline report, company report or official report of Cartesian Therapeutics. DM1UO4S RU https://www.cartesiantherapeutics.com/clinical-trials/ DMTY4KN DI DMTY4KN DMTY4KN DN Dexefaroxan DMTY4KN MI TTM2AOE DMTY4KN MN Adenosine A2a receptor (ADORA2A) DMTY4KN MT DTT DMTY4KN MA Agonist DMTY4KN RN The pipeline and future of drug development in schizophrenia. Mol Psychiatry. 2007 Oct;12(10):904-22. DMTY4KN RU https://pubmed.ncbi.nlm.nih.gov/17667958 DMTY4KN DI DMTY4KN DMTY4KN DN Dexefaroxan DMTY4KN MI TTJSZTB DMTY4KN MN Nicotinic acetylcholine receptor (nAChR) DMTY4KN MT DTT DMTY4KN MA Agonist DMTY4KN RN The pipeline and future of drug development in schizophrenia. Mol Psychiatry. 2007 Oct;12(10):904-22. DMTY4KN RU https://pubmed.ncbi.nlm.nih.gov/17667958 DM52HUD DI DM52HUD DM52HUD DN Dexloxiglumide DM52HUD MI TTCG0AL DM52HUD MN Cholecystokinin receptor type A (CCKAR) DM52HUD MT DTT DM52HUD MA Inhibitor DM52HUD RN Full agonists of CCK8 containing a nonhydrolyzable sulfated tyrosine residue. J Med Chem. 1989 Feb;32(2):445-9. DM52HUD RU https://pubmed.ncbi.nlm.nih.gov/2464062 DM52HUD DI DM52HUD DM52HUD DN Dexloxiglumide DM52HUD MI DEPKLMQ DM52HUD MN Cytochrome P450 2B6 (CYP2B6) DM52HUD MT DME DM52HUD MA Metabolism DM52HUD RN Effect of azole antifungals ketoconazole and fluconazole on the pharmacokinetics of dexloxiglumide. Br J Clin Pharmacol. 2005 Nov;60(5):498-507. DM52HUD RU https://www.ncbi.nlm.nih.gov/pubmed/?term=16236040 DM52HUD DI DM52HUD DM52HUD DN Dexloxiglumide DM52HUD MI DE5IED8 DM52HUD MN Cytochrome P450 2C9 (CYP2C9) DM52HUD MT DME DM52HUD MA Metabolism DM52HUD RN Pharmacokinetic profile of dexloxiglumide. Clin Pharmacokinet. 2006;45(12):1177-88. DM52HUD RU https://www.ncbi.nlm.nih.gov/pubmed/?term=17112294 DM52HUD DI DM52HUD DM52HUD DN Dexloxiglumide DM52HUD MI DE4LYSA DM52HUD MN Cytochrome P450 3A4 (CYP3A4) DM52HUD MT DME DM52HUD MA Metabolism DM52HUD RN Pharmacokinetic profile of dexloxiglumide. Clin Pharmacokinet. 2006;45(12):1177-88. DM52HUD RU https://www.ncbi.nlm.nih.gov/pubmed/?term=17112294 DM52HUD DI DM52HUD DM52HUD DN Dexloxiglumide DM52HUD MI DEIBDNY DM52HUD MN Cytochrome P450 3A5 (CYP3A5) DM52HUD MT DME DM52HUD MA Metabolism DM52HUD RN Pharmacokinetic profile of dexloxiglumide. Clin Pharmacokinet. 2006;45(12):1177-88. DM52HUD RU https://www.ncbi.nlm.nih.gov/pubmed/?term=17112294 DM52HUD DI DM52HUD DM52HUD DN Dexloxiglumide DM52HUD MI TTVFO0U DM52HUD MN Gastrin/cholecystokinin type B receptor (CCKBR) DM52HUD MT DTT DM52HUD MA Inhibitor DM52HUD RN Synthesis and stereochemical structure-activity relationships of 1,3-dioxoperhydropyrido[1,2-c]pyrimidine derivatives: potent and selective cholecy... J Med Chem. 1997 Oct 10;40(21):3402-7. DM52HUD RU https://pubmed.ncbi.nlm.nih.gov/9341915 DM9L15R DI DM9L15R DM9L15R DN Dextofisopam DM9L15R MI TTNJYV2 DM9L15R MN Gamma-aminobutyric acid receptor (GAR) DM9L15R MT DTT DM9L15R MA Agonist DM9L15R RN Emerging drugs for irritable bowel syndrome. Expert Opin Emerg Drugs. 2006 May;11(2):293-313. DM9L15R RU https://pubmed.ncbi.nlm.nih.gov/16634703 DM9L15R DI DM9L15R DM9L15R DN Dextofisopam DM9L15R MI TTPTXIN DM9L15R MN Translocator protein (TSPO) DM9L15R MT DTT DM9L15R MA Agonist DM9L15R RN Emerging drugs for irritable bowel syndrome. Expert Opin Emerg Drugs. 2006 May;11(2):293-313. DM9L15R RU https://pubmed.ncbi.nlm.nih.gov/16634703 DMFI5J4 DI DMFI5J4 DMFI5J4 DN Dextromethorphan+quinidine DMFI5J4 MI TTSZLWK DMFI5J4 MN Aromatase (CYP19A1) DMFI5J4 MT DTT DMFI5J4 MA Inhibitor DMFI5J4 RN Emerging drugs in neuropathic pain. Expert Opin Emerg Drugs. 2007 Mar;12(1):113-26. DMFI5J4 RU https://pubmed.ncbi.nlm.nih.gov/17355217 DMFI5J4 DI DMFI5J4 DMFI5J4 DN Dextromethorphan+quinidine DMFI5J4 MI TT9IK2Z DMFI5J4 MN N-methyl-D-aspartate receptor (NMDAR) DMFI5J4 MT DTT DMFI5J4 MA Antagonist DMFI5J4 RN Emerging drugs in neuropathic pain. Expert Opin Emerg Drugs. 2007 Mar;12(1):113-26. DMFI5J4 RU https://pubmed.ncbi.nlm.nih.gov/17355217 DMS9Y1T DI DMS9Y1T DMS9Y1T DN DG-17 DMS9Y1T MI TT5FNQT DMS9Y1T MN Human immunodeficiency virus Protease (HIV PR) DMS9Y1T MT DTT DMS9Y1T MA Inhibitor DMS9Y1T RN Highly drug-resistant HIV-1 clinical isolates are cross-resistant to many antiretroviral compounds in current clinical development. AIDS. 1999 April 16; 13(6): 661-667. DMS9Y1T RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2566777/ DMK6FYR DI DMK6FYR DMK6FYR DN DiabeCell DMK6FYR MI TTXQYT6 DMK6FYR MN T-cells (T-cells) DMK6FYR MT DTT DMK6FYR MA Modulator DMK6FYR RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015 DMK6FYR RU https://www.accessdata.fda.gov/scripts/cder/drugsatfda/ DMTJOEL DI DMTJOEL DMTJOEL DN DIADENOSINE TETRAPHOSPHATE DMTJOEL MI TTSLI08 DMTJOEL MN Adenosine receptor (ADOR) DMTJOEL MT DTT DMTJOEL MA Modulator DMTJOEL RN Negative chronotropic and inotropic effects exerted by diadenosine hexaphosphate (AP6A) via A1-adenosine receptors. Br J Pharmacol. 1996 Nov;119(5):835-44. DMTJOEL RU https://pubmed.ncbi.nlm.nih.gov/8922729 DM7AFJ8 DI DM7AFJ8 DM7AFJ8 DN Diannexin DM7AFJ8 MI TT2Z83I DM7AFJ8 MN Annexin A5 (ANXA5) DM7AFJ8 MT DTT DM7AFJ8 MA Modulator DM7AFJ8 RN Expression and purification of recombinant human annexin V in Escherichia coli. Prep Biochem Biotechnol. 2000 Nov;30(4):305-12. DM7AFJ8 RU https://pubmed.ncbi.nlm.nih.gov/11065275 DM20ATW DI DM20ATW DM20ATW DN Diflomotecan DM20ATW MI DTI7UX6 DM20ATW MN Breast cancer resistance protein (ABCG2) DM20ATW MT DTP DM20ATW MA Substrate DM20ATW RN Pharmacogenomic importance of ABCG2. Pharmacogenomics. 2008 Aug;9(8):1005-9. DM20ATW RU https://doi.org/10.2217/14622416.9.8.1005 DM20ATW DI DM20ATW DM20ATW DN Diflomotecan DM20ATW MI TTGTQHC DM20ATW MN DNA topoisomerase I (TOP1) DM20ATW MT DTT DM20ATW MA Inhibitor DM20ATW RN Diflomotecan, a promising homocamptothecin for cancer therapy. Expert Opin Investig Drugs. 2009 Jan;18(1):69-75. DM20ATW RU https://pubmed.ncbi.nlm.nih.gov/19053883 DMTLB92 DI DMTLB92 DMTLB92 DN DI-Leu16-IL2 DMTLB92 MI TTUE541 DMTLB92 MN Leukocyte surface antigen Leu-16 (CD20) DMTLB92 MT DTT DMTLB92 MA Modulator DMTLB92 RN National Cancer Institute Drug Dictionary (drug id 599668). DMTLB92 RU http://www.cancer.gov/publications/dictionaries/cancer-drug?cdrid=599668 DMBYJ92 DI DMBYJ92 DMBYJ92 DN Dilmapimod DMBYJ92 MI TTQBR95 DMBYJ92 MN Stress-activated protein kinase 2a (p38 alpha) DMBYJ92 MT DTT DMBYJ92 MA Inhibitor DMBYJ92 RN Clinical pipeline report, company report or official report of GlaxoSmithKline (2009). DMBYJ92 RU http://www.gsk.com/investors/product_pipeline/docs/gsk-pipeline-feb09.pdf DMCATH2 DI DMCATH2 DMCATH2 DN Dilpacimab DMCATH2 MI TTV23LH DMCATH2 MN Delta-like protein 4 (DLL4) DMCATH2 MT DTT DMCATH2 RN Apoptogenic activity of 2alpha,3alpha-dihydroxyurs-12-ene-28-oic acid from Prunella vulgaris var. lilacina is mediated via mitochondria-dependent activation of caspase cascade regulated by Bcl-2 in human acute leukemia Jurkat T cells. J Ethnopharmacol. 2011 Jun 1;135(3):626-35. DMCATH2 RU https://pubmed.ncbi.nlm.nih.gov/21473903 DMCATH2 DI DMCATH2 DMCATH2 DN Dilpacimab DMCATH2 MI TT9HKJA DMCATH2 MN Vascular endothelial growth factor (VEGF) DMCATH2 MT DTT DMCATH2 RN Apoptogenic activity of 2alpha,3alpha-dihydroxyurs-12-ene-28-oic acid from Prunella vulgaris var. lilacina is mediated via mitochondria-dependent activation of caspase cascade regulated by Bcl-2 in human acute leukemia Jurkat T cells. J Ethnopharmacol. 2011 Jun 1;135(3):626-35. DMCATH2 RU https://pubmed.ncbi.nlm.nih.gov/21473903 DM96NHM DI DM96NHM DM96NHM DN Dimiracetam DM96NHM MI TT9IK2Z DM96NHM MN N-methyl-D-aspartate receptor (NMDAR) DM96NHM MT DTT DM96NHM MA Antagonist DM96NHM RN Broad spectrum and prolonged efficacy of dimiracetam in models of neuropathic pain. Neuropharmacology. 2014 Jun;81:85-94. DM96NHM RU https://pubmed.ncbi.nlm.nih.gov/24486381 DM2QBDS DI DM2QBDS DM2QBDS DN Disitertide DM2QBDS MI TTR9XHZ DM2QBDS MN Transforming growth factor beta 1 (TGFB1) DM2QBDS MT DTT DM2QBDS MA Inhibitor DM2QBDS RN Perspectives of TGF-beta inhibition in pancreatic and hepatocellular carcinomas. Oncotarget. 2014 January; 5(1): 78-94. DM2QBDS RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3960190/ DMYC2LE DI DMYC2LE DMYC2LE DN Disufenton DMYC2LE MI TTLQTHB DMYC2LE MN Extracellular sulfatase Sulf-2 (SULF2) DMYC2LE MT DTT DMYC2LE MA Inhibitor DMYC2LE RN The human sulfatase 2 inhibitor 2,4-disulfonylphenyl-tert-butylnitrone (OKN-007) has an antitumor effect in hepatocellular carcinoma mediated via suppression of TGFB1/SMAD2 and Hedgehog/GLI1 signaling. Genes Chromosomes Cancer. 2013 Mar;52(3):225-36. DMYC2LE RU https://pubmed.ncbi.nlm.nih.gov/23109092 DMBMKV8 DI DMBMKV8 DMBMKV8 DN Disulfiram DMBMKV8 MI TTNHMO8 DMBMKV8 MN COVID-19 papain-like proteinase (PL-PRO) DMBMKV8 MT DTT DMBMKV8 MA Inhibitor DMBMKV8 RN Structure of Mpro from COVID-19 virus and discovery of its inhibitors. Nature. 2020 Apr 9. DMBMKV8 RU https://pubmed.ncbi.nlm.nih.gov/32272481 DMBMKV8 DI DMBMKV8 DMBMKV8 DN Disulfiram DMBMKV8 MI TTYJOLE DMBMKV8 MN MERS-CoV papain-like proteinase (PL-PRO) DMBMKV8 MT DTT DMBMKV8 MA Inhibitor DMBMKV8 RN Therapeutic options for the 2019 novel coronavirus (2019-nCoV). Nat Rev Drug Discov. 2020 Mar;19(3):149-150. DMBMKV8 RU https://pubmed.ncbi.nlm.nih.gov/32127666 DMBMKV8 DI DMBMKV8 DMBMKV8 DN Disulfiram DMBMKV8 MI TTRGHB2 DMBMKV8 MN SARS-CoV papain-like proteinase (PL-PRO) DMBMKV8 MT DTT DMBMKV8 MA Inhibitor DMBMKV8 RN Therapeutic options for the 2019 novel coronavirus (2019-nCoV). Nat Rev Drug Discov. 2020 Mar;19(3):149-150. DMBMKV8 RU https://pubmed.ncbi.nlm.nih.gov/32127666 DMOHT5V DI DMOHT5V DMOHT5V DN DKN-01 DMOHT5V MI TTE3RAC DMOHT5V MN Dickkopf-related protein 1 (DKK1) DMOHT5V MT DTT DMOHT5V MA Inhibitor DMOHT5V RN The anti-DKK1 antibody DKN-01 as an immunomodulatory combination partner for the treatment of cancer. Expert Opin Investig Drugs. 2020 Jul;29(7):639-644. DMOHT5V RU https://pubmed.ncbi.nlm.nih.gov/32408777 DMDJUWG DI DMDJUWG DMDJUWG DN DLX-105 DMDJUWG MI TTF8CQI DMDJUWG MN Tumor necrosis factor (TNF) DMDJUWG MT DTT DMDJUWG RN Cyclic AMP inhibition of tumor necrosis factor alpha production induced by amyloidogenic C-terminal peptide of Alzheimer's amyloid precursor protein in macrophages: involvement of multiple intracellular pathways and cyclic AMP response element binding protein. Mol Pharmacol. 2003 Mar;63(3):690-8. DMDJUWG RU https://pubmed.ncbi.nlm.nih.gov/12606779 DM0157T DI DM0157T DM0157T DN DM199 DM0157T MI TTGY8IW DM0157T MN B2 bradykinin receptor (BDKRB2) DM0157T MT DTT DM0157T MA Activator DM0157T RN Pharmacological effects of recombinant human tissue kallikrein on bradykinin B2 receptors. Pharmacol Res Perspect. 2015 Mar;3(2):e00119. DM0157T RU https://pubmed.ncbi.nlm.nih.gov/26038695 DMMSIG7 DI DMMSIG7 DMMSIG7 DN DM-71 DMMSIG7 MI TTCBFJO DMMSIG7 MN Insulin receptor (INSR) DMMSIG7 MT DTT DMMSIG7 MA Modulator DMMSIG7 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1800). DMMSIG7 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1800 DM1HG3U DI DM1HG3U DM1HG3U DN DM-99 DM1HG3U MI TTCBFJO DM1HG3U MN Insulin receptor (INSR) DM1HG3U MT DTT DM1HG3U MA Agonist DM1HG3U RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1800). DM1HG3U RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1800 DMBC7HZ DI DMBC7HZ DMBC7HZ DN DM-CHOC-PEN DMBC7HZ MI TTUTN1I DMBC7HZ MN Human Deoxyribonucleic acid (hDNA) DMBC7HZ MT DTT DMBC7HZ MA Modulator DMBC7HZ RN Carbonate and carbamate derivatives of 4-demethylpenclomedine as novel anticancer agents. Cancer Chemother Pharmacol. 2009 September; 64(4): 829-835. DMBC7HZ RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2717391/ DM725UG DI DM725UG DM725UG DN DN24-02 DM725UG MI TT6EO5L DM725UG MN Erbb2 tyrosine kinase receptor (HER2) DM725UG MT DTT DM725UG MA Modulator DM725UG RN Treatment with autologous antigen-presenting cells activated with the HER-2 based antigen Lapuleucel-T: results of a phase I study in immunologic and clinical activity in HER-2 overexpressing breast cancer. J Clin Oncol. 2007 Aug 20;25(24):3680-7. DM725UG RU https://pubmed.ncbi.nlm.nih.gov/17704416 DMDTVYC DI DMDTVYC DMDTVYC DN DNCB DMDTVYC MI DER3H9C DMDTVYC MN Lipocalin-type prostaglandin-D synthase (PTGDS) DMDTVYC MT DME DMDTVYC MA Metabolism DMDTVYC RN Glutathione transferases immobilized on nanoporous alumina: flow system kinetics, screening, and stability. Anal Biochem. 2014 Feb 1;446:59-63. DMDTVYC RU https://www.ncbi.nlm.nih.gov/pubmed/?term=24157647 DMDTVYC DI DMDTVYC DMDTVYC DN DNCB DMDTVYC MI DE3OALH DMDTVYC MN Prostaglandin E synthase 2 (PTGES2) DMDTVYC MT DME DMDTVYC MA Metabolism DMDTVYC RN Human microsomal prostaglandin E synthase-1: purification, functional characterization, and projection structure determination. J Biol Chem. 2003 Jun 20;278(25):22199-209. DMDTVYC RU https://www.ncbi.nlm.nih.gov/pubmed/?term=12672824 DM89D6C DI DM89D6C DM89D6C DN DNL758 DM89D6C MI TTAIQSN DM89D6C MN Receptor-interacting protein 1 (RIPK1) DM89D6C MT DTT DM89D6C MA Inhibitor DM89D6C RN Receptor-interacting protein kinase 1 (RIPK1) as a therapeutic target. Nat Rev Drug Discov. 2020 Aug;19(8):553-571. DM89D6C RU https://pubmed.ncbi.nlm.nih.gov/32669658 DM0QDC9 DI DM0QDC9 DM0QDC9 DN Dolastatin 10 DM0QDC9 MI DTUGYRD DM0QDC9 MN P-glycoprotein 1 (ABCB1) DM0QDC9 MT DTP DM0QDC9 MA Substrate DM0QDC9 RN Competition of hydrophobic peptides, cytotoxic drugs, and chemosensitizers on a common P-glycoprotein pharmacophore as revealed by its ATPase activity. J Biol Chem. 1996 Feb 9;271(6):3163-71. DM0QDC9 RU http://www.ncbi.nlm.nih.gov/pubmed/8621716 DMDUV1S DI DMDUV1S DMDUV1S DN DOLASTATIN-10 DMDUV1S MI TTML2WA DMDUV1S MN Tubulin (TUB) DMDUV1S MT DTT DMDUV1S MA Inhibitor DMDUV1S RN Synthesis and biological activity of chimeric structures derived from the cytotoxic natural compounds dolastatin 10 and dolastatin 15. J Med Chem. 1998 Apr 23;41(9):1524-30. DMDUV1S RU https://pubmed.ncbi.nlm.nih.gov/9554885 DMDUV1S DI DMDUV1S DMDUV1S DN DOLASTATIN-10 DMDUV1S MI TTYFKSZ DMDUV1S MN Tubulin beta (TUBB) DMDUV1S MT DTT DMDUV1S MA Inhibitor DMDUV1S RN Total synthesis and biological evaluation of ustiloxin natural products and two analogs. Bioorg Med Chem Lett. 2006 Sep 15;16(18):4804-7. DMDUV1S RU https://pubmed.ncbi.nlm.nih.gov/16837194 DMDUV1S DI DMDUV1S DMDUV1S DN DOLASTATIN-10 DMDUV1S MI TTJ2PTI DMDUV1S MN Tubulin beta-2 chain (TUBB2) DMDUV1S MT DTT DMDUV1S MA Inhibitor DMDUV1S RN Total synthesis and biological evaluation of ustiloxin natural products and two analogs. Bioorg Med Chem Lett. 2006 Sep 15;16(18):4804-7. DMDUV1S RU https://pubmed.ncbi.nlm.nih.gov/16837194 DMCT08V DI DMCT08V DMCT08V DN Domagrozumab DMCT08V MI TTSWPH8 DMCT08V MN Growth/differentiation factor 8 (GDF-8) DMCT08V MT DTT DMCT08V MA Inhibitor DMCT08V RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMCT08V RU http://phrma-docs.phrma.org/files/dmfile/MID_Neurological-Disorders-Drug-List_2018.pdf DM8VWPH DI DM8VWPH DM8VWPH DN Doxorubicin-eluting beads DM8VWPH MI TT0IHXV DM8VWPH MN DNA topoisomerase II (TOP2) DM8VWPH MT DTT DM8VWPH MA Modulator DM8VWPH RN Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41. DM8VWPH RU https://www.ncbi.nlm.nih.gov/pubmed/15950434 DM059CZ DI DM059CZ DM059CZ DN DPK-060 DM059CZ MI TTXT4D5 DM059CZ MN Bacterial Cell membrane (Bact CM) DM059CZ MT DTT DM059CZ MA Enhancer DM059CZ RN The re-emergence of natural products for drug discovery in the genomics era. Nat Rev Drug Discov. 2015 Feb;14(2):111-29. DM059CZ RU https://pubmed.ncbi.nlm.nih.gov/25614221 DMMC3XR DI DMMC3XR DMMC3XR DN DPV-001 DMMC3XR MI TTOK0LR DMMC3XR MN Toll-like receptor (TLR) DMMC3XR MT DTT DMMC3XR MA Modulator DMMC3XR RN UbiVac's DRibble, autophagosome-enriched vaccines: Applications for cancer and infectious disease. UbiVac. 2013. DMMC3XR RU http://ubivac.com/zap/?page_id=2668 DMGD3XT DI DMGD3XT DMGD3XT DN DRL-17822 DMGD3XT MI TTFQAYR DMGD3XT MN Cholesteryl ester transfer protein (CETP) DMGD3XT MT DTT DMGD3XT MA Inhibitor DMGD3XT RN The dyslipidaemia market. Nat Rev Drug Discov. 2014 Nov;13(11):807-8. DMGD3XT RU https://pubmed.ncbi.nlm.nih.gov/25323928 DM8WU3O DI DM8WU3O DM8WU3O DN Drug 2862277 DM8WU3O MI TTG043C DM8WU3O MN Tumor necrosis factor receptor type I (TNF-R1) DM8WU3O MT DTT DM8WU3O RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1870). DM8WU3O RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1870 DMI69E5 DI DMI69E5 DMI69E5 DN DS-3201b DMI69E5 MI TTNJA0C DMI69E5 MN Enhancer of zeste homolog 1 (EZH1) DMI69E5 MT DTT DMI69E5 MA Inhibitor DMI69E5 RN Development of new agents for peripheral T-cell lymphoma. Expert Opin Biol Ther. 2019 Mar;19(3):197-209. DMI69E5 RU https://pubmed.ncbi.nlm.nih.gov/30658046 DMI69E5 DI DMI69E5 DMI69E5 DN DS-3201b DMI69E5 MI TT9MZCQ DMI69E5 MN Enhancer of zeste homolog 2 (EZH2) DMI69E5 MT DTT DMI69E5 MA Inhibitor DMI69E5 RN Development of new agents for peripheral T-cell lymphoma. Expert Opin Biol Ther. 2019 Mar;19(3):197-209. DMI69E5 RU https://pubmed.ncbi.nlm.nih.gov/30658046 DMUXIRM DI DMUXIRM DMUXIRM DN DS-8500 DMUXIRM MI TT7QNVC DMUXIRM MN Glucose-dependent insulinotropic receptor (GPR119) DMUXIRM MT DTT DMUXIRM MA Modulator DMUXIRM RN Addressing Unmet Medical Needs in Type 2 Diabetes: A Narrative Review of Drugs under Development. Curr Diabetes Rev. 2015 March; 11(1): 17-31. DMUXIRM RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4428473/ DM6UGHA DI DM6UGHA DM6UGHA DN DSP-6952 DM6UGHA MI TT07C3Y DM6UGHA MN 5-HT 4 receptor (HTR4) DM6UGHA MT DTT DM6UGHA MA Agonist DM6UGHA RN DSP-6952, a high affinity serotonin (5-HT4) receptor partial agonist. Sumitomo Dainippon Pharma Co. Ltd. DM6UGHA RU http://www.biocentury.com/products/dsp-6952 DMU2GP4 DI DMU2GP4 DMU2GP4 DN DT-1687 DMU2GP4 MI TTICZ1O DMU2GP4 MN Metabotropic glutamate receptor 4 (mGluR4) DMU2GP4 MT DTT DMU2GP4 MA Modulator DMU2GP4 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 292). DMU2GP4 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=292 DMV84OK DI DMV84OK DMV84OK DN DTI-0009 DMV84OK MI TTK25J1 DMV84OK MN Adenosine A1 receptor (ADORA1) DMV84OK MT DTT DMV84OK MA Agonist DMV84OK RN Recent developments in adenosine receptor ligands and their potential as novel drugs. Biochim Biophys Acta. 2011 May;1808(5):1290-308. DMV84OK RU https://pubmed.ncbi.nlm.nih.gov/21185259 DMX27IT DI DMX27IT DMX27IT DN DTRM-555 DMX27IT MI TTGM6VW DMX27IT MN Tyrosine-protein kinase BTK (ATK) DMX27IT MT DTT DMX27IT MA Inhibitor DMX27IT RN ClinicalTrials.gov (NCT04305444) Study of a Triple Combination Therapy, DTRM-555, in Patients With R/R CLL or R/R Non-Hodgkin's Lymphomas. U.S. National Institutes of Health. DMX27IT RU https://clinicaltrials.gov/ct2/show/NCT04305444 DM1ZJYS DI DM1ZJYS DM1ZJYS DN Dusigitumab DM1ZJYS MI TTE8WGO DM1ZJYS MN Insulin-like growth factor-II (IGF2) DM1ZJYS MT DTT DM1ZJYS MA Inhibitor DM1ZJYS RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DM1ZJYS RU http://phrma-docs.phrma.org/files/dmfile/MID_Immuno-Oncology-2017_Drug-List1.pdf DM7USVA DI DM7USVA DM7USVA DN Duvelisib DM7USVA MI TTK5FVJ DM7USVA MN HUMAN PI3-kinase delta (PIK3CD) DM7USVA MT DTT DM7USVA MA Inhibitor DM7USVA RN ClinicalTrials.gov (NCT04372602) Duvelisib to Combat COVID-19. U.S. National Institutes of Health. DM7USVA RU https://clinicaltrials.gov/ct2/show/NCT04372602 DM7USVA DI DM7USVA DM7USVA DN Duvelisib DM7USVA MI TTHXGLJ DM7USVA MN HUMAN PI3-kinase gamma (PIK3CG) DM7USVA MT DTT DM7USVA MA Inhibitor DM7USVA RN ClinicalTrials.gov (NCT04372602) Duvelisib to Combat COVID-19. U.S. National Institutes of Health. DM7USVA RU https://clinicaltrials.gov/ct2/show/NCT04372602 DMUGBQK DI DMUGBQK DMUGBQK DN DVC1-0101 DMUGBQK MI TTGKIED DMUGBQK MN Fibroblast growth factor-2 (FGF2) DMUGBQK MT DTT DMUGBQK MA Modulator DMUGBQK RN DVC1-0101 to treat peripheral arterial disease: a Phase I/IIa open-label dose-escalation clinical trial. Mol Ther. 2013 Mar;21(3):707-14. DMUGBQK RU https://pubmed.ncbi.nlm.nih.gov/23319060 DMQKU2F DI DMQKU2F DMQKU2F DN DWP-05195 DMQKU2F MI TTMI6F5 DMQKU2F MN Transient receptor potential cation channel V1 (TRPV1) DMQKU2F MT DTT DMQKU2F MA Antagonist DMQKU2F RN TRPV1 Antagonists as Analgesic Agents. The Open Pain Journal, 2013, 6, (Suppl 1: M11), 108-118 . DMQKU2F RU http://benthamopen.com/contents/pdf/TOPAINJ/TOPAINJ-6-108.pdf DMBFZET DI DMBFZET DMBFZET DN DX-890 DMBFZET MI TTPLTSQ DMBFZET MN Neutrophil elastase (NE) DMBFZET MT DTT DMBFZET MA Inhibitor DMBFZET RN Emerging therapies for treatment of acute lung injury and acute respiratory distress syndrome. Expert Opin Emerg Drugs. 2007 Sep;12(3):461-77. DMBFZET RU https://pubmed.ncbi.nlm.nih.gov/17874973 DMDYWM8 DI DMDYWM8 DMDYWM8 DN E-10030 DMDYWM8 MI TTQA6SX DMDYWM8 MN Platelet-derived growth factor B (PDGFB) DMDYWM8 MT DTT DMDYWM8 MA Antagonist DMDYWM8 RN Aptamers as therapeutics. Nat Rev Drug Discov. 2010 Jul;9(7):537-50. DMDYWM8 RU https://pubmed.ncbi.nlm.nih.gov/20592747 DMLS269 DI DMLS269 DMLS269 DN E-1224 DMLS269 MI TTTSOUD DMLS269 MN Candida Cytochrome P450 51 (Candi ERG11) DMLS269 MT DTT DMLS269 MA Inhibitor DMLS269 RN Recent Developments in Sterol 14-demethylase Inhibitors for Chagas Disease. Int J Parasitol Drugs Drug Resist. 2012 Dec;2:236-242. DMLS269 RU https://pubmed.ncbi.nlm.nih.gov/23277882 DMK8SY6 DI DMK8SY6 DMK8SY6 DN E2027 DMK8SY6 MI TTZOEBC DMK8SY6 MN Phosphodiesterase 9 (PDE9) DMK8SY6 MT DTT DMK8SY6 MA Antagonist DMK8SY6 RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMK8SY6 RU http://phrma-docs.phrma.org/files/dmfile/MID_Neurological-Disorders-Drug-List_2018.pdf DMC5PB2 DI DMC5PB2 DMC5PB2 DN E-4716 DMC5PB2 MI TTTIBOJ DMC5PB2 MN Histamine H1 receptor (H1R) DMC5PB2 MT DTT DMC5PB2 MA Modulator DMC5PB2 RN Population pharmacokinetics of epinastine, a histamine H1 receptor antagonist, in adults and children. Br J Clin Pharmacol. 2005 Jan;59(1):43-53. DMC5PB2 RU https://pubmed.ncbi.nlm.nih.gov/15606439 DMQERC6 DI DMQERC6 DMQERC6 DN E5555 DMQERC6 MI TTL935N DMQERC6 MN Proteinase activated receptor 1 (F2R) DMQERC6 MT DTT DMQERC6 MA Antagonist DMQERC6 RN Safety and tolerability of atopaxar in the treatment of patients with acute coronary syndromes: the lessons from antagonizing the cellular effects of Thrombin-Acute Coronary Syndromes Trial. Circulation. 2011 May 3;123(17):1843-53. DMQERC6 RU https://pubmed.ncbi.nlm.nih.gov/21502577 DM1S489 DI DM1S489 DM1S489 DN E6005 DM1S489 MI DEB30C5 DM1S489 MN Carboxylesterase 1 (CES1) DM1S489 MT DME DM1S489 MA Metabolism DM1S489 RN Safety and efficacy of topical E6005, a phosphodiesterase 4 inhibitor, in Japanese adult patients with atopic dermatitis: results of a randomized, vehicle-controlled, multicenter clinical trial. J Dermatol. 2014 Jul;41(7):577-85. DM1S489 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=24942594 DM1S489 DI DM1S489 DM1S489 DN E6005 DM1S489 MI TTV5CGO DM1S489 MN Phosphodiesterase 4 (PDE4) DM1S489 MT DTT DM1S489 MA Inhibitor DM1S489 RN Antipruritic effect of the topical phosphodiesterase 4 inhibitor E6005 ameliorates skin lesions in a mouse atopic dermatitis model. J Pharmacol Exp Ther. 2013 Jul;346(1):105-12. DM1S489 RU https://pubmed.ncbi.nlm.nih.gov/23674603 DMOSL9P DI DMOSL9P DMOSL9P DN E6201 DMOSL9P MI TTROQ37 DMOSL9P MN MAPK/ERK kinase kinase (MAP3K) DMOSL9P MT DTT DMOSL9P MA Modulator DMOSL9P RN E6201, a novel kinase inhibitor of mitogen-activated protein kinase/extracellular signal-regulated kinase kinase-1 and mitogen-activated protein kinase/extracellular signal-regulated kinase kinase kinase-1: in vivo effects on cutaneous inflammatory responses by topical administration. J Pharmacol Exp Ther. 2010 Oct;335(1):23-31. DMOSL9P RU https://pubmed.ncbi.nlm.nih.gov/20627998 DMUWJI4 DI DMUWJI4 DMUWJI4 DN E-6700 DMUWJI4 MI TT2J34L DMUWJI4 MN Arachidonate 5-lipoxygenase (5-LOX) DMUWJI4 MT DTT DMUWJI4 MA Modulator DMUWJI4 RN Structure-activity relationships of (E)-3-(1,4-benzoquinonyl)-2-[(3-pyridyl)-alkyl]-2-propenoic acid derivatives that inhibit both 5-lipoxygenase and thromboxane A2 synthetase. J Med Chem. 1996 Aug 2;39(16):3148-57. DMUWJI4 RU https://pubmed.ncbi.nlm.nih.gov/8759636 DMUWJI4 DI DMUWJI4 DMUWJI4 DN E-6700 DMUWJI4 MI TTKNWZ4 DMUWJI4 MN Thromboxane-A synthase (TBXAS1) DMUWJI4 MT DTT DMUWJI4 MA Modulator DMUWJI4 RN Structure-activity relationships of (E)-3-(1,4-benzoquinonyl)-2-[(3-pyridyl)-alkyl]-2-propenoic acid derivatives that inhibit both 5-lipoxygenase and thromboxane A2 synthetase. J Med Chem. 1996 Aug 2;39(16):3148-57. DMUWJI4 RU https://pubmed.ncbi.nlm.nih.gov/8759636 DMAHGKE DI DMAHGKE DMAHGKE DN E7016 DMAHGKE MI TTEBCY8 DMAHGKE MN Poly [ADP-ribose] polymerase (PARP) DMAHGKE MT DTT DMAHGKE MA Modulator DMAHGKE RN Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41. DMAHGKE RU https://www.ncbi.nlm.nih.gov/pubmed/15950434 DMZRXTL DI DMZRXTL DMZRXTL DN E7820 DMZRXTL MI TTSJ542 DMZRXTL MN Integrin alpha-2 (ITGA2) DMZRXTL MT DTT DMZRXTL MA Inhibitor DMZRXTL RN Phase I study of E7820, an oral inhibitor of integrin alpha-2 expression with antiangiogenic properties, in patients with advanced malignancies. Clin Cancer Res. 2011 Jan 1;17(1):193-200. DMZRXTL RU https://pubmed.ncbi.nlm.nih.gov/21208908 DM8K5IF DI DM8K5IF DM8K5IF DN E7850 DM8K5IF MI TT9ABMF DM8K5IF MN Serine/threonine-protein kinase Chk2 (RAD53) DM8K5IF MT DTT DM8K5IF MA Modulator DM8K5IF RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1988). DM8K5IF RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1988 DM753H8 DI DM753H8 DM753H8 DN EB8018 DM753H8 MI TTTCRU2 DM753H8 MN Bacterial Fimbrin D-mannose adhesin (Bact FimH) DM753H8 MT DTT DM753H8 MA Inhibitor DM753H8 RN Clinical pipeline report, company report or official report of Enterome Biosciences. DM753H8 RU https://www.enterome.com/#pipeline DM0KVJC DI DM0KVJC DM0KVJC DN EC-145 DM0KVJC MI TTVC37M DM0KVJC MN Folate receptor alpha (FOLR1) DM0KVJC MT DTT DM0KVJC MA Modulator DM0KVJC RN Significance of Folate Receptor alpha and Thymidylate Synthase Protein Expression in Patients with Non-Small Cell Lung Cancer treated with Pemetrexed. J Thorac Oncol. 2013 January; 8(1): 19-30. DM0KVJC RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3645936/ DM1LDIP DI DM1LDIP DM1LDIP DN Econail DM1LDIP MI TTTSOUD DM1LDIP MN Candida Cytochrome P450 51 (Candi ERG11) DM1LDIP MT DTT DM1LDIP MA Inhibitor DM1LDIP RN Azole binding properties of Candida albicans sterol 14-alpha demethylase (CaCYP51). Antimicrob Agents Chemother. 2010 Oct;54(10):4235-45. DM1LDIP RU https://pubmed.ncbi.nlm.nih.gov/20625155 DMKAUM9 DI DMKAUM9 DMKAUM9 DN Eculizumab DMKAUM9 MI TTN0GJ5 DMKAUM9 MN HUMAN complement C5 protein (C5) DMKAUM9 MT DTT DMKAUM9 MA Inhibitor DMKAUM9 RN Complement as a target in COVID-19 Nat Rev Immunol. 2020 Apr 23. DMKAUM9 RU https://pubmed.ncbi.nlm.nih.gov/32327719 DMQ08AJ DI DMQ08AJ DMQ08AJ DN Edotreotide DMQ08AJ MI TTOMNR9 DMQ08AJ MN Somatostatin receptor (SSTR) DMQ08AJ MT DTT DMQ08AJ MA Modulator DMQ08AJ RN Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41. DMQ08AJ RU https://www.ncbi.nlm.nih.gov/pubmed/15950434 DMGJYZ8 DI DMGJYZ8 DMGJYZ8 DN EDP-305 DMGJYZ8 MI TTS4UGC DMGJYZ8 MN Farnesoid X-activated receptor (FXR) DMGJYZ8 MT DTT DMGJYZ8 MA Agonist DMGJYZ8 RN A novel non-bile acid FXR agonist EDP-305 potently suppresses liver injury and fibrosis without worsening of ductular reaction. Liver Int. 2020 Jul;40(7):1655-1669. DMGJYZ8 RU https://pubmed.ncbi.nlm.nih.gov/32329946 DM5WZ0O DI DM5WZ0O DM5WZ0O DN EDP-420 DM5WZ0O MI TTLFGBV DM5WZ0O MN Bacterial 23S ribosomal RNA (Bact 23S rRNA) DM5WZ0O MT DTT DM5WZ0O MA Inhibitor DM5WZ0O RN EDP-420, a Bicyclolide (Bridged Bicyclic Macrolide), Is Active against Mycobacterium avium. Antimicrob Agents Chemother. 2007 May; 51(5): 1666-1670. DM5WZ0O RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1855536/ DM32UOC DI DM32UOC DM32UOC DN EDP-938 DM32UOC MI TT25A0I DM32UOC MN Respiratory syncytial virus protein N (RSV N) DM32UOC MT DTT DM32UOC MA Inhibitor DM32UOC RN EDP-938, a novel nucleoprotein inhibitor of respiratory syncytial virus, demonstrates potent antiviral activities in vitro and in a non-human primate model. PLoS Pathog. 2021 Mar 15;17(3):e1009428. DM32UOC RU https://pubmed.ncbi.nlm.nih.gov/33720995 DMX4RSD DI DMX4RSD DMX4RSD DN EFEGATRAN SULFATE HYDRATE DMX4RSD MI TT6L509 DMX4RSD MN Coagulation factor IIa (F2) DMX4RSD MT DTT DMX4RSD MA Inhibitor DMX4RSD RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015 DMX4RSD RU https://www.accessdata.fda.gov/scripts/cder/drugsatfda/ DMX6RZG DI DMX6RZG DMX6RZG DN EFT508 DMX6RZG MI TTRECN3 DMX6RZG MN MAP kinase signal-integrating kinase 2 (MKNK2) DMX6RZG MT DTT DMX6RZG MA Inhibitor DMX6RZG RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMX6RZG RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DMX6RZG DI DMX6RZG DMX6RZG DN EFT508 DMX6RZG MI TTEZAUX DMX6RZG MN MAPK signal-integrating kinase 1 (MKNK1) DMX6RZG MT DTT DMX6RZG MA Inhibitor DMX6RZG RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMX6RZG RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DMBHP56 DI DMBHP56 DMBHP56 DN Efungumab DMBHP56 MI TT78R5H DMBHP56 MN Heat shock protein 90 alpha (HSP90A) DMBHP56 MT DTT DMBHP56 RN Efungumab: a novel agent in the treatment of invasive candidiasis. Ann Pharmacother. 2009 Nov;43(11):1818-23. DMBHP56 RU https://pubmed.ncbi.nlm.nih.gov/19773528 DM6L5TR DI DM6L5TR DM6L5TR DN EGEN-001 DM6L5TR MI TTGW72V DM6L5TR MN Interleukin-12 beta (IL12B) DM6L5TR MT DTT DM6L5TR MA Modulator DM6L5TR RN National Cancer Institute Drug Dictionary (drug id 454593). DM6L5TR RU http://www.cancer.gov/publications/dictionaries/cancer-drug?cdrid=454593 DMN1SWB DI DMN1SWB DMN1SWB DN EGS-21 DMN1SWB MI TTCBFJO DMN1SWB MN Insulin receptor (INSR) DMN1SWB MT DTT DMN1SWB MA Modulator DMN1SWB RN Ceramides and glucosylceramides are independent antagonists of insulin signaling. J Biol Chem. 2014 Jan 10;289(2):723-34. DMN1SWB RU https://pubmed.ncbi.nlm.nih.gov/24214972 DML7WP0 DI DML7WP0 DML7WP0 DN Eldacimibe DML7WP0 MI TTMF541 DML7WP0 MN Liver carboxylesterase (CES1) DML7WP0 MT DTT DML7WP0 MA Modulator DML7WP0 RN Prospects for drug therapy for hyperlipoproteinaemia. Diabete Metab. 1995 Apr;21(2):139-46. DML7WP0 RU https://pubmed.ncbi.nlm.nih.gov/7621974 DMCSXI4 DI DMCSXI4 DMCSXI4 DN Elezanumab DMCSXI4 MI TTURJV4 DMCSXI4 MN Repulsive guidance molecule A (RGMA) DMCSXI4 MT DTT DMCSXI4 MA Inhibitor DMCSXI4 RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMCSXI4 RU http://phrma-docs.phrma.org/files/dmfile/MID_Neurological-Disorders-Drug-List_2018.pdf DMIOGZM DI DMIOGZM DMIOGZM DN ELIPRODIL DMIOGZM MI TTLD29N DMIOGZM MN Glutamate receptor ionotropic NMDA 1 (NMDAR1) DMIOGZM MT DTT DMIOGZM MA Inhibitor DMIOGZM RN 4-Hydroxy-1-[2-(4-hydroxyphenoxy)ethyl]-4-(4-methylbenzyl)piperidine: a novel, potent, and selective NR1/2B NMDA receptor antagonist. J Med Chem. 1999 Jul 29;42(15):2993-3000. DMIOGZM RU https://pubmed.ncbi.nlm.nih.gov/10425109 DMIOGZM DI DMIOGZM DMIOGZM DN ELIPRODIL DMIOGZM MI TTN9D8E DMIOGZM MN Glutamate receptor ionotropic NMDA 2B (NMDAR2B) DMIOGZM MT DTT DMIOGZM MA Inhibitor DMIOGZM RN 4-Hydroxy-1-[2-(4-hydroxyphenoxy)ethyl]-4-(4-methylbenzyl)piperidine: a novel, potent, and selective NR1/2B NMDA receptor antagonist. J Med Chem. 1999 Jul 29;42(15):2993-3000. DMIOGZM RU https://pubmed.ncbi.nlm.nih.gov/10425109 DMB38KH DI DMB38KH DMB38KH DN Elisidepsin DMB38KH MI TTDC8N2 DMB38KH MN Erbb3 tyrosine kinase receptor (Erbb-3) DMB38KH MT DTT DMB38KH MA Inhibitor DMB38KH RN Molecular pharmacodynamics of PM02734 (elisidepsin) as single agent and in combination with erlotinib; synergistic activity in human non-small cell lung cancer cell lines and xenograft models. Eur J Cancer. 2009 Jul;45(10):1855-64. DMB38KH RU https://pubmed.ncbi.nlm.nih.gov/19346126 DMR50I7 DI DMR50I7 DMR50I7 DN Elsamitrucin DMR50I7 MI TT0IHXV DMR50I7 MN DNA topoisomerase II (TOP2) DMR50I7 MT DTT DMR50I7 MA Modulator DMR50I7 RN Elsamicin A binding to DNA. A comparative thermodynamic characterization. FEBS Lett. 2004 Oct 8;576(1-2):68-72. DMR50I7 RU https://pubmed.ncbi.nlm.nih.gov/15474012 DMB7CPG DI DMB7CPG DMB7CPG DN Elsiglutide DMB7CPG MI TT1YWO5 DMB7CPG MN Glucagon-like peptide 2 receptor (GLP2R) DMB7CPG MT DTT DMB7CPG MA Modulator DMB7CPG RN Poster Abstracts. Volume 10, Issue Supplement S8, pages 126-209, December 2014. DMB7CPG RU http://onlinelibrary.wiley.com/doi/10.1111/ajco.12305/abstract DMYOUB6 DI DMYOUB6 DMYOUB6 DN EMA-401 DMYOUB6 MI TTQVOEI DMYOUB6 MN Angiotensin II receptor type-2 (AGTR2) DMYOUB6 MT DTT DMYOUB6 MA Antagonist DMYOUB6 RN Clinical pipeline report, company report or official report of Spinifex. DMYOUB6 RU http://www.spinifexpharma.com/EMA401-DEVELOPMENT.html DMCLT2F DI DMCLT2F DMCLT2F DN Emepepimut-S DMCLT2F MI TTBHFYQ DMCLT2F MN Mucin-1 (MUC1) DMCLT2F MT DTT DMCLT2F RN Emepepimut-S for non-small cell lung cancer. Expert Opin Biol Ther. 2011 Aug;11(8):1091-7. DMCLT2F RU https://pubmed.ncbi.nlm.nih.gov/21689064 DMT4MKF DI DMT4MKF DMT4MKF DN Emibetuzumab DMT4MKF MI TTNDSF4 DMT4MKF MN Proto-oncogene c-Met (MET) DMT4MKF MT DTT DMT4MKF MA Inhibitor DMT4MKF RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMT4MKF RU http://phrma-docs.phrma.org/files/dmfile/MID_Immuno-Oncology-2017_Drug-List1.pdf DMQH1NV DI DMQH1NV DMQH1NV DN Emivirine DMQH1NV MI DE4LYSA DMQH1NV MN Cytochrome P450 3A4 (CYP3A4) DMQH1NV MT DME DMQH1NV MA Metabolism DMQH1NV RN Safety assessment, in vitro and in vivo, and pharmacokinetics of emivirine, a potent and selective nonnucleoside reverse transcriptase inhibitor of human immunodeficiency virus type 1. Antimicrob Agents Chemother. 2000 Jan;44(1):123-30. DMQH1NV RU https://www.ncbi.nlm.nih.gov/pubmed/?term=10602732 DMQH1NV DI DMQH1NV DMQH1NV DN Emivirine DMQH1NV MI DEIBDNY DMQH1NV MN Cytochrome P450 3A5 (CYP3A5) DMQH1NV MT DME DMQH1NV MA Metabolism DMQH1NV RN Safety assessment, in vitro and in vivo, and pharmacokinetics of emivirine, a potent and selective nonnucleoside reverse transcriptase inhibitor of human immunodeficiency virus type 1. Antimicrob Agents Chemother. 2000 Jan;44(1):123-30. DMQH1NV RU https://www.ncbi.nlm.nih.gov/pubmed/?term=10602732 DMQH1NV DI DMQH1NV DMQH1NV DN Emivirine DMQH1NV MI TT84ETX DMQH1NV MN Human immunodeficiency virus Reverse transcriptase (HIV RT) DMQH1NV MT DTT DMQH1NV MA Modulator DMQH1NV RN Etravirine: a second-generation nonnucleoside reverse transcriptase inhibitor (NNRTI) active against NNRTI-resistant strains of HIV.Clin Ther.2009 Apr;31(4):692-704. DMQH1NV RU https://www.ncbi.nlm.nih.gov/pubmed/19446143 DMDEL3F DI DMDEL3F DMDEL3F DN EMZ701 DMDEL3F MI TTSYFMA DMDEL3F MN Interferon alpha/beta receptor 1 (IFNAR1) DMDEL3F MT DTT DMDEL3F MA Modulator DMDEL3F RN Patent EP2766021 A1. DMDEL3F RU http://www.google.com/patents/EP2766021A1?cl=en DMGFZOL DI DMGFZOL DMGFZOL DN Enadoline DMGFZOL MI TTQW87Y DMGFZOL MN Opioid receptor kappa (OPRK1) DMGFZOL MT DTT DMGFZOL MA Agonist DMGFZOL RN Enadoline, a selective kappa-opioid receptor agonist shows potent antihyperalgesic and antiallodynic actions in a rat model of surgical pain. Pain. 1999 Mar;80(1-2):383-9. DMGFZOL RU https://pubmed.ncbi.nlm.nih.gov/10204752 DMM8Z3Q DI DMM8Z3Q DMM8Z3Q DN Encequidar DMM8Z3Q MI TTJUXV6 DMM8Z3Q MN Multidrug resistance protein 3 (ABCB4) DMM8Z3Q MT DTT DMM8Z3Q MA Inhibitor DMM8Z3Q RN Discovery of Encequidar, First-in-Class Intestine Specific P-glycoprotein Inhibitor. J Med Chem. 2021 Apr 8;64(7):3677-3693. DMM8Z3Q RU https://pubmed.ncbi.nlm.nih.gov/33729781 DM8NLDI DI DM8NLDI DM8NLDI DN Endostatin DM8NLDI MI TTBPXMA DM8NLDI MN Prolactin receptor (PRLR) DM8NLDI MT DTT DM8NLDI MA Modulator DM8NLDI RN Prolactin antagonist-endostatin fusion protein as a targeted dual-functional therapeutic agent for breast cancer. Cancer Res. 2003 Jul 1;63(13):3598-604. DM8NLDI RU https://pubmed.ncbi.nlm.nih.gov/12839947 DMTX8IZ DI DMTX8IZ DMTX8IZ DN Endoxifen DMTX8IZ MI TTZAYWL DMTX8IZ MN Estrogen receptor (ESR) DMTX8IZ MT DTT DMTX8IZ MA Modulator DMTX8IZ RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 620). DMTX8IZ RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=620 DMMIHSO DI DMMIHSO DMMIHSO DN ENERGI-F701 DMMIHSO MI TTLAFZV DMMIHSO MN AMP-activated protein kinase (AMPK) DMMIHSO MT DTT DMMIHSO MA Activator DMMIHSO RN Clinical pipeline report, company report or official report of Energenesis Biomedical. DMMIHSO RU https://www.energenesis-biomedical.com/_en/tech_detail.php?id=186 DM96NCR DI DM96NCR DM96NCR DN Eniluracil DM96NCR MI TTZPS91 DM96NCR MN Dihydrothymine dehydrogenase (DPYD) DM96NCR MT DTT DM96NCR MA Modulator DM96NCR RN Eniluracil: an irreversible inhibitor of dihydropyrimidine dehydrogenase. Expert Opin Investig Drugs. 2000 Jul;9(7):1635-49. DM96NCR RU https://pubmed.ncbi.nlm.nih.gov/11060767 DMJZVPB DI DMJZVPB DMJZVPB DN ENMD-2076 DMJZVPB MI TTPS3C0 DMJZVPB MN Aurora kinase A (AURKA) DMJZVPB MT DTT DMJZVPB MA Inhibitor DMJZVPB RN Cell cycle kinases as therapeutic targets for cancer. Nat Rev Drug Discov. 2009 Jul;8(7):547-66. DMJZVPB RU https://pubmed.ncbi.nlm.nih.gov/19568282 DMJZVPB DI DMJZVPB DMJZVPB DN ENMD-2076 DMJZVPB MI TTU8W4S DMJZVPB MN Protein kinase (PK) DMJZVPB MT DTT DMJZVPB MA Inhibitor DMJZVPB RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMJZVPB RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DMDS20X DI DMDS20X DMDS20X DN Enoblituzumab DMDS20X MI TT6CQUM DMDS20X MN B7 homolog 3 (CD276) DMDS20X MT DTT DMDS20X MA Inhibitor DMDS20X RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMDS20X RU http://phrma-docs.phrma.org/files/dmfile/MID_Immuno-Oncology-2017_Drug-List1.pdf DMLPRZJ DI DMLPRZJ DMLPRZJ DN Ensaculin hydrochloride DMLPRZJ MI TTSQIFT DMLPRZJ MN 5-HT 1A receptor (HTR1A) DMLPRZJ MT DTT DMLPRZJ MA Modulator DMLPRZJ RN Ensaculin (KA-672 HCl): a multitransmitter approach to dementia treatment. CNS Drug Rev. 2002 Summer;8(2):143-58. DMLPRZJ RU https://pubmed.ncbi.nlm.nih.gov/12177685 DM69NF1 DI DM69NF1 DM69NF1 DN EP-101 DM69NF1 MI TTOXS3C DM69NF1 MN Muscarinic acetylcholine receptor (CHRM) DM69NF1 MT DTT DM69NF1 MA Antagonist DM69NF1 RN Long-acting muscarinic receptor antagonists for the treatment of respiratory disease. Pulm Pharmacol Ther. 2013 Jun;26(3):307-17. DM69NF1 RU https://pubmed.ncbi.nlm.nih.gov/23274274 DMPC4EK DI DMPC4EK DMPC4EK DN EP-217609 DMPC4EK MI TT6L509 DMPC4EK MN Coagulation factor IIa (F2) DMPC4EK MT DTT DMPC4EK MA Modulator DMPC4EK RN Specificity and selectivity profile of EP217609: a new neutralizable dual-action anticoagulant that targets thrombin and factor Xa.Blood.2012 Mar 8;119(10):2187-95. DMPC4EK RU https://www.ncbi.nlm.nih.gov/pubmed/22144183 DMPC4EK DI DMPC4EK DMPC4EK DN EP-217609 DMPC4EK MI TTCIHJA DMPC4EK MN Coagulation factor Xa (F10) DMPC4EK MT DTT DMPC4EK MA Modulator DMPC4EK RN Specificity and selectivity profile of EP217609: a new neutralizable dual-action anticoagulant that targets thrombin and factor Xa.Blood.2012 Mar 8;119(10):2187-95. DMPC4EK RU https://www.ncbi.nlm.nih.gov/pubmed/22144183 DMZT7EP DI DMZT7EP DMZT7EP DN EPI 589 DMZT7EP MI TTIB5LO DMZT7EP MN Quinone reductase (NQO) DMZT7EP MT DTT DMZT7EP MA Modulator DMZT7EP RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMZT7EP RU http://phrma-docs.phrma.org/files/dmfile/MID_Neurological-Disorders-Drug-List_2018.pdf DMWK26Q DI DMWK26Q DMWK26Q DN EPX-200 DMWK26Q MI TT85JO3 DMWK26Q MN 5-HT receptor (5HTR) DMWK26Q MT DTT DMWK26Q MA Modulator DMWK26Q RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMWK26Q RU http://phrma-docs.phrma.org/files/dmfile/MID_Neurological-Disorders-Drug-List_2018.pdf DMUXDGZ DI DMUXDGZ DMUXDGZ DN EPX-300 DMUXDGZ MI TT85JO3 DMUXDGZ MN 5-HT receptor (5HTR) DMUXDGZ MT DTT DMUXDGZ MA Modulator DMUXDGZ RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMUXDGZ RU http://phrma-docs.phrma.org/files/dmfile/MID_Neurological-Disorders-Drug-List_2018.pdf DMD4YRG DI DMD4YRG DMD4YRG DN EQ-917 DMD4YRG MI TTGTQHC DMD4YRG MN DNA topoisomerase I (TOP1) DMD4YRG MT DTT DMD4YRG MA Inhibitor DMD4YRG RN The efficacy and toxicity of belotecan (CKD-602), a camptothericin analogue topoisomerase I inhibitor, in patients with recurrent or refractory epithelial ovarian cancer. J Chemother. 2010 Jun;22(3):197-200. DMD4YRG RU https://pubmed.ncbi.nlm.nih.gov/20566426 DMCEPUA DI DMCEPUA DMCEPUA DN ERB-041 DMCEPUA MI TTOM3J0 DMCEPUA MN Estrogen receptor beta (ESR2) DMCEPUA MT DTT DMCEPUA MA Agonist DMCEPUA RN Erb-041, an estrogen receptor-beta agonist, inhibits skin photocarcinogenesis in SKH-1 hairless mice by downregulating the WNT signaling pathway. Cancer Prev Res (Phila). 2014 Feb;7(2):186-98. DMCEPUA RU https://pubmed.ncbi.nlm.nih.gov/24217507 DMU1XZD DI DMU1XZD DMU1XZD DN Erteberel DMU1XZD MI TTOM3J0 DMU1XZD MN Estrogen receptor beta (ESR2) DMU1XZD MT DTT DMU1XZD MA Agonist DMU1XZD RN Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800031986) DMU1XZD RU http://adisinsight.springer.com/drugs/800031986 DM5Z3VP DI DM5Z3VP DM5Z3VP DN Ertumaxomab DM5Z3VP MI TT6EO5L DM5Z3VP MN Erbb2 tyrosine kinase receptor (HER2) DM5Z3VP MT DTT DM5Z3VP RN Trifunctional antibody ertumaxomab: Non-immunological effects on Her2 receptor activity and downstream signaling. MAbs. 2012 Sep-Oct;4(5):614-22. DM5Z3VP RU https://pubmed.ncbi.nlm.nih.gov/22820509 DM5Z3VP DI DM5Z3VP DM5Z3VP DN Ertumaxomab DM5Z3VP MI TTZAT79 DM5Z3VP MN T-cell surface glycoprotein CD3 epsilon (CD3E) DM5Z3VP MT DTT DM5Z3VP RN Trifunctional antibody ertumaxomab: Non-immunological effects on Her2 receptor activity and downstream signaling. MAbs. 2012 Sep-Oct;4(5):614-22. DM5Z3VP RU https://pubmed.ncbi.nlm.nih.gov/22820509 DM5Z3VP DI DM5Z3VP DM5Z3VP DN Ertumaxomab DM5Z3VP MI TTV3XPL DM5Z3VP MN T-cell surface glycoprotein CD3 gamma (CD3G) DM5Z3VP MT DTT DM5Z3VP RN Trifunctional antibody ertumaxomab: Non-immunological effects on Her2 receptor activity and downstream signaling. MAbs. 2012 Sep-Oct;4(5):614-22. DM5Z3VP RU https://pubmed.ncbi.nlm.nih.gov/22820509 DMYZWDC DI DMYZWDC DMYZWDC DN ESBA-105 DMYZWDC MI TTF8CQI DMYZWDC MN Tumor necrosis factor (TNF) DMYZWDC MT DTT DMYZWDC RN Pharmacokinetics and posterior segment biodistribution of ESBA105, an anti-TNF-alpha single-chain antibody, upon topical administration to the rabbit eye. Invest Ophthalmol Vis Sci. 2009 Feb;50(2):771-8. DMYZWDC RU https://pubmed.ncbi.nlm.nih.gov/18757508 DMTB63Q DI DMTB63Q DMTB63Q DN Estetrol DMTB63Q MI TTZAYWL DMTB63Q MN Estrogen receptor (ESR) DMTB63Q MT DTT DMTB63Q MA Modulator DMTB63Q RN Clinical pipeline report, company report or official report of Pantarhei Bioscience. DMTB63Q RU http://pantarheibio.com/pipeline/estetrol.htm DM71BZV DI DM71BZV DM71BZV DN Etamicastat DM71BZV MI TTYIP79 DM71BZV MN Dopamine beta hydroxylase (DBH) DM71BZV MT DTT DM71BZV MA Inhibitor DM71BZV RN Safety, tolerability, and pharmacokinetics of etamicastat, a novel dopamine-beta-hydroxylase inhibitor, in a rising multiple-dose study in young healthy subjects. Drugs R D. 2010;10(4):225-42. DM71BZV RU https://pubmed.ncbi.nlm.nih.gov/21171669 DMOCID7 DI DMOCID7 DMOCID7 DN Etazolate DMOCID7 MI TTEX6LM DMOCID7 MN GABA(A) receptor gamma-3 (GABRG3) DMOCID7 MT DTT DMOCID7 MA Modulator DMOCID7 RN Etazolate, a neuroprotective drug linking GABA(A) receptor pharmacology to amyloid precursor protein processing. J Neurochem. 2008 Jul;106(1):392-404. DMOCID7 RU https://pubmed.ncbi.nlm.nih.gov/18397369 DM68K39 DI DM68K39 DM68K39 DN ETIPREDNOL DICLOACETATE DM68K39 MI TTYRL6O DM68K39 MN Glucocorticoid receptor (NR3C1) DM68K39 MT DTT DM68K39 MA Modulator DM68K39 RN Advances in corticosteroid therapy for ocular inflammation: loteprednol etabonate.Int J Inflam.2012;2012:789623. DM68K39 RU https://www.ncbi.nlm.nih.gov/pubmed/22536546 DMV96BY DI DMV96BY DMV96BY DN ETS-6218 DMV96BY MI TT7CXIM DMV96BY MN Histamine receptor (HR) DMV96BY MT DTT DMV96BY MA Modulator DMV96BY RN Clinical pipeline report, company report or official report of e-Therapeutics. DMV96BY RU http://www.etherapeutics.co.uk/wp-content/uploads/2014/12/etp-10594-ar-08-web.pdf DMZOA2L DI DMZOA2L DMZOA2L DN ETX-9101 DMZOA2L MI TT7CXIM DMZOA2L MN Histamine receptor (HR) DMZOA2L MT DTT DMZOA2L MA Modulator DMZOA2L RN Clinical pipeline report, company report or official report of e-Therapeutics. DMZOA2L RU http://www.etherapeutics.co.uk/wp-content/uploads/2014/12/etp-10594-ar-08-web.pdf DM1FCDH DI DM1FCDH DM1FCDH DN EV-077 DM1FCDH MI TTKNWZ4 DM1FCDH MN Thromboxane-A synthase (TBXAS1) DM1FCDH MT DTT DM1FCDH MA Modulator DM1FCDH RN Company report (Pharmaceuticalintelligence) DM1FCDH RU http://pharmaceuticalintelligence.com/tag/diabetic-nephropathy/ DMWB94K DI DMWB94K DMWB94K DN Evenamide DMWB94K MI TTIG65Q DMWB94K MN Voltage-gated sodium channel (Nav) DMWB94K MT DTT DMWB94K MA Blocker DMWB94K RN Clinical pipeline report, company report or official report of Newron Pharmaceuticals. DMWB94K RU https://www.newron.com/science#evenamide DM8QXEY DI DM8QXEY DM8QXEY DN Evt201 DM8QXEY MI TTCI43M DM8QXEY MN GABA(A) receptor (GABAR) DM8QXEY MT DTT DM8QXEY MA Modulator DM8QXEY RN The partial positive allosteric GABA(A) receptor modulator EVT 201 is efficacious and safe in the treatment of adult primary insomnia patients. Sleep Med. 2009 Sep;10(8):859-64. DM8QXEY RU https://pubmed.ncbi.nlm.nih.gov/19345644 DMQGBM1 DI DMQGBM1 DMQGBM1 DN EVT-201 DMQGBM1 MI TT1MPAY DMQGBM1 MN GABA(A) receptor alpha-1 (GABRA1) DMQGBM1 MT DTT DMQGBM1 MA Modulator DMQGBM1 RN Antibodies and venom peptides: new modalities for ion channels. Nat Rev Drug Discov. 2019 May;18(5):339-357. DMQGBM1 RU https://pubmed.ncbi.nlm.nih.gov/30728472 DMQGBM1 DI DMQGBM1 DMQGBM1 DN EVT-201 DMQGBM1 MI TTEX6LM DMQGBM1 MN GABA(A) receptor gamma-3 (GABRG3) DMQGBM1 MT DTT DMQGBM1 MA Modulator DMQGBM1 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 415). DMQGBM1 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=415 DM73XNG DI DM73XNG DM73XNG DN EVT302 DM73XNG MI TTGP7BY DM73XNG MN Monoamine oxidase type B (MAO-B) DM73XNG MT DTT DM73XNG MA Inhibitor DM73XNG RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DM73XNG RU http://phrma-docs.phrma.org/files/dmfile/MID_Neurological-Disorders-Drug-List_2018.pdf DM4FBUH DI DM4FBUH DM4FBUH DN EXC 001 DM4FBUH MI TTCJVNE DM4FBUH MN CTGF messenger RNA (CTGF mRNA) DM4FBUH MT DTT DM4FBUH RN Clinical pipeline report, company report or official report of ISIS Pharmaceuticals (2011). DM4FBUH RU http://www.isispharm.com/index.htm DMC1I56 DI DMC1I56 DMC1I56 DN Exherin DMC1I56 MI TT1WS0T DMC1I56 MN Neural cadherin (CDH2) DMC1I56 MT DTT DMC1I56 MA Binder DMC1I56 RN Clinical and pharmacological phase I evaluation of Exherin (ADH-1), a selective anti-N-cadherin peptide in patients with N-cadherin-expressing soli... Ann Oncol. 2009 Apr;20(4):741-5. DMC1I56 RU https://pubmed.ncbi.nlm.nih.gov/19190075 DM5PBLM DI DM5PBLM DM5PBLM DN EYP001 DM5PBLM MI TTS4UGC DM5PBLM MN Farnesoid X-activated receptor (FXR) DM5PBLM MT DTT DM5PBLM MA Agonist DM5PBLM RN Clinical pipeline report, company report or official report of ENYO Pharma. DM5PBLM RU http://www.enyopharma.com/pipeline/eyp001-in-nash/ DM2L9CO DI DM2L9CO DM2L9CO DN Ezatiostat DM2L9CO MI TT40K12 DM2L9CO MN Glutathione S-transferase P (GSTP1) DM2L9CO MT DTT DM2L9CO MA Modulator DM2L9CO RN National Cancer Institute Drug Dictionary (drug id 485244). DM2L9CO RU http://www.cancer.gov/publications/dictionaries/cancer-drug?cdrid=485244 DMJ4BKT DI DMJ4BKT DMJ4BKT DN F-16-IL-2 fusion protein DMJ4BKT MI TTUCPMY DMJ4BKT MN Tenascin (TNC) DMJ4BKT MT DTT DMJ4BKT MA Modulator DMJ4BKT RN National Cancer Institute Drug Dictionary (drug id 674718). DMJ4BKT RU http://www.cancer.gov/publications/dictionaries/cancer-drug?cdrid=674718 DMKP3SJ DI DMKP3SJ DMKP3SJ DN F-351 DMKP3SJ MI TTRAXK5 DMKP3SJ MN Aminotransferase (AT) DMKP3SJ MT DTT DMKP3SJ MA Inhibitor DMKP3SJ RN Expansion of the clavulanic acid gene cluster: identification and in vivo functional analysis of three new genes required for biosynthesis of clavulanic acid by Streptomyces clavuligerus. J Bacteriol. 2000 Jul;182(14):4087-95. DMKP3SJ RU https://pubmed.ncbi.nlm.nih.gov/10869089 DM6UQNW DI DM6UQNW DM6UQNW DN F4co vaccine DM6UQNW MI TTTWS2G DM6UQNW MN Human immunodeficiency virus Capsid p24 (HIV p24) DM6UQNW MT DTT DM6UQNW RN EP patent application no. 2621528, Vaccine. DM6UQNW RU http://worldwide.espacenet.com/publicationDetails/biblio?DB=worldwide.espacenet.com&II=0&ND=3&adjacent=true&locale=en_EP&FT=D&date=20130807&CC=EP&NR=2621528A1&KC=A1 DM6UQNW DI DM6UQNW DM6UQNW DN F4co vaccine DM6UQNW MI TTI3NXG DM6UQNW MN Human immunodeficiency virus Matrix p17 (HIV MA) DM6UQNW MT DTT DM6UQNW RN EP patent application no. 2621528, Vaccine. DM6UQNW RU http://worldwide.espacenet.com/publicationDetails/biblio?DB=worldwide.espacenet.com&II=0&ND=3&adjacent=true&locale=en_EP&FT=D&date=20130807&CC=EP&NR=2621528A1&KC=A1 DM6UQNW DI DM6UQNW DM6UQNW DN F4co vaccine DM6UQNW MI TT4NXYM DM6UQNW MN Human immunodeficiency virus Negative factor (HIV nef) DM6UQNW MT DTT DM6UQNW RN EP patent application no. 2621528, Vaccine. DM6UQNW RU http://worldwide.espacenet.com/publicationDetails/biblio?DB=worldwide.espacenet.com&II=0&ND=3&adjacent=true&locale=en_EP&FT=D&date=20130807&CC=EP&NR=2621528A1&KC=A1 DM6UQNW DI DM6UQNW DM6UQNW DN F4co vaccine DM6UQNW MI TT84ETX DM6UQNW MN Human immunodeficiency virus Reverse transcriptase (HIV RT) DM6UQNW MT DTT DM6UQNW RN EP patent application no. 2621528, Vaccine. DM6UQNW RU http://worldwide.espacenet.com/publicationDetails/biblio?DB=worldwide.espacenet.com&II=0&ND=3&adjacent=true&locale=en_EP&FT=D&date=20130807&CC=EP&NR=2621528A1&KC=A1 DMDNJ18 DI DMDNJ18 DMDNJ18 DN F-627 DMDNJ18 MI TT5TQ2W DMDNJ18 MN Granulocyte colony-stimulating factor (CSF3) DMDNJ18 MT DTT DMDNJ18 MA Modulator DMDNJ18 RN Clinical pipeline report, company report or official report of Generon (Shanghai) Corporation Ltd. DMDNJ18 RU http://www.generonbiomed.com/html/en/index.php?ac=article&at=list&tid=29 DMBFPO1 DI DMBFPO1 DMBFPO1 DN F-8-IL-10 fusion protein DMBFPO1 MI TTT0Q1F DMBFPO1 MN Interleukin-10 (IL10) DMBFPO1 MT DTT DMBFPO1 MA Modulator DMBFPO1 RN Preclinical characterization of DEKAVIL (F8-IL10), a novel clinical-stage immunocytokine which inhibits the progression of collagen-induced arthritis. Arthritis Res Ther. 2009;11(5):R142. DMBFPO1 RU https://pubmed.ncbi.nlm.nih.gov/19781067 DM2CUS0 DI DM2CUS0 DM2CUS0 DN F901318 DM2CUS0 MI TTTSUI2 DM2CUS0 MN Aspergillus Dihydroorotate dehydrogenase (Aspergillus DHODH) DM2CUS0 MT DTT DM2CUS0 MA Inhibitor DM2CUS0 RN Effect of the Novel Antifungal Drug F901318 (Olorofim) on Growth and Viability of Aspergillus fumigatus. Antimicrob Agents Chemother. 2018 Jul 27;62(8):e00231-18. DM2CUS0 RU https://pubmed.ncbi.nlm.nih.gov/29891595 DMXB6KG DI DMXB6KG DMXB6KG DN FAD-104 DMXB6KG MI TTUTN1I DMXB6KG MN Human Deoxyribonucleic acid (hDNA) DMXB6KG MT DTT DMXB6KG MA Binder DMXB6KG RN Biological activities of new anthracyclines containing fluorine, FAD104 and its metabolites. J Antibiot (Tokyo). 1990 May;43(5):556-65. DMXB6KG RU https://pubmed.ncbi.nlm.nih.gov/1694165 DM6RKG3 DI DM6RKG3 DM6RKG3 DN Fadolmidine DM6RKG3 MI TTQ8AFT DM6RKG3 MN Adrenergic receptor Alpha-2 (ADRA2) DM6RKG3 MT DTT DM6RKG3 MA Agonist DM6RKG3 RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DM6RKG3 RU http://phrma-docs.phrma.org/files/dmfile/MID_Neurological-Disorders-Drug-List_2018.pdf DM6RKG3 DI DM6RKG3 DM6RKG3 DN Fadolmidine DM6RKG3 MI TT2NUT5 DM6RKG3 MN Adrenergic receptor alpha-2C (ADRA2C) DM6RKG3 MT DTT DM6RKG3 MA Agonist DM6RKG3 RN Antinociceptive properties of fadolmidine (MPV-2426), a novel alpha2-adrenoceptor agonist. CNS Drug Rev. 2004 Summer;10(2):117-26. DM6RKG3 RU https://pubmed.ncbi.nlm.nih.gov/15179442 DMSFWT7 DI DMSFWT7 DMSFWT7 DN Famitinib DMSFWT7 MI DE6OQ3W DMSFWT7 MN Cytochrome P450 1A1 (CYP1A1) DMSFWT7 MT DME DMSFWT7 MA Metabolism DMSFWT7 RN Metabolism and bioactivation of famitinib, a novel inhibitor of receptor tyrosine kinase, in cancer patients. Br J Pharmacol. 2013 Apr;168(7):1687-706. DMSFWT7 RU http://www.ncbi.nlm.nih.gov/pubmed/23126373 DMSFWT7 DI DMSFWT7 DMSFWT7 DN Famitinib DMSFWT7 MI DEJGDUW DMSFWT7 MN Cytochrome P450 1A2 (CYP1A2) DMSFWT7 MT DME DMSFWT7 MA Metabolism DMSFWT7 RN Metabolism and bioactivation of famitinib, a novel inhibitor of receptor tyrosine kinase, in cancer patients. Br J Pharmacol. 2013 Apr;168(7):1687-706. DMSFWT7 RU http://www.ncbi.nlm.nih.gov/pubmed/23126373 DMSFWT7 DI DMSFWT7 DMSFWT7 DN Famitinib DMSFWT7 MI DE4LYSA DMSFWT7 MN Cytochrome P450 3A4 (CYP3A4) DMSFWT7 MT DME DMSFWT7 MA Metabolism DMSFWT7 RN Metabolism and bioactivation of famitinib, a novel inhibitor of receptor tyrosine kinase, in cancer patients. Br J Pharmacol. 2013 Apr;168(7):1687-706. DMSFWT7 RU http://www.ncbi.nlm.nih.gov/pubmed/23126373 DMSFWT7 DI DMSFWT7 DMSFWT7 DN Famitinib DMSFWT7 MI DEIBDNY DMSFWT7 MN Cytochrome P450 3A5 (CYP3A5) DMSFWT7 MT DME DMSFWT7 MA Metabolism DMSFWT7 RN Metabolism and bioactivation of famitinib, a novel inhibitor of receptor tyrosine kinase, in cancer patients. Br J Pharmacol. 2013 Apr;168(7):1687-706. DMSFWT7 RU http://www.ncbi.nlm.nih.gov/pubmed/23126373 DMSFWT7 DI DMSFWT7 DMSFWT7 DN Famitinib DMSFWT7 MI TTGJCWZ DMSFWT7 MN Fms-like tyrosine kinase 3 (FLT-3) DMSFWT7 MT DTT DMSFWT7 MA Inhibitor DMSFWT7 RN Metabolism and bioactivation of famitinib, a novel inhibitor of receptor tyrosine kinase, in cancer patients. Br J Pharmacol. 2013 Apr;168(7):1687-706. DMSFWT7 RU https://pubmed.ncbi.nlm.nih.gov/23126373 DMSFWT7 DI DMSFWT7 DMSFWT7 DN Famitinib DMSFWT7 MI TT8FYO9 DMSFWT7 MN Platelet-derived growth factor receptor alpha (PDGFRA) DMSFWT7 MT DTT DMSFWT7 MA Inhibitor DMSFWT7 RN Metabolism and bioactivation of famitinib, a novel inhibitor of receptor tyrosine kinase, in cancer patients. Br J Pharmacol. 2013 Apr;168(7):1687-706. DMSFWT7 RU https://pubmed.ncbi.nlm.nih.gov/23126373 DMSFWT7 DI DMSFWT7 DMSFWT7 DN Famitinib DMSFWT7 MI TTI7421 DMSFWT7 MN Platelet-derived growth factor receptor beta (PDGFRB) DMSFWT7 MT DTT DMSFWT7 MA Inhibitor DMSFWT7 RN Metabolism and bioactivation of famitinib, a novel inhibitor of receptor tyrosine kinase, in cancer patients. Br J Pharmacol. 2013 Apr;168(7):1687-706. DMSFWT7 RU https://pubmed.ncbi.nlm.nih.gov/23126373 DMSFWT7 DI DMSFWT7 DMSFWT7 DN Famitinib DMSFWT7 MI TTX41N9 DMSFWT7 MN Tyrosine-protein kinase Kit (KIT) DMSFWT7 MT DTT DMSFWT7 MA Inhibitor DMSFWT7 RN Metabolism and bioactivation of famitinib, a novel inhibitor of receptor tyrosine kinase, in cancer patients. Br J Pharmacol. 2013 Apr;168(7):1687-706. DMSFWT7 RU https://pubmed.ncbi.nlm.nih.gov/23126373 DMSFWT7 DI DMSFWT7 DMSFWT7 DN Famitinib DMSFWT7 MI TT2Q6G1 DMSFWT7 MN Vascular endothelial growth factor receptor 1 (FLT-1) DMSFWT7 MT DTT DMSFWT7 MA Inhibitor DMSFWT7 RN Metabolism and bioactivation of famitinib, a novel inhibitor of receptor tyrosine kinase, in cancer patients. Br J Pharmacol. 2013 Apr;168(7):1687-706. DMSFWT7 RU https://pubmed.ncbi.nlm.nih.gov/23126373 DMSFWT7 DI DMSFWT7 DMSFWT7 DN Famitinib DMSFWT7 MI TTUTJGQ DMSFWT7 MN Vascular endothelial growth factor receptor 2 (KDR) DMSFWT7 MT DTT DMSFWT7 MA Inhibitor DMSFWT7 RN Metabolism and bioactivation of famitinib, a novel inhibitor of receptor tyrosine kinase, in cancer patients. Br J Pharmacol. 2013 Apr;168(7):1687-706. DMSFWT7 RU https://pubmed.ncbi.nlm.nih.gov/23126373 DMSFWT7 DI DMSFWT7 DMSFWT7 DN Famitinib DMSFWT7 MI TTDCBX5 DMSFWT7 MN Vascular endothelial growth factor receptor 3 (FLT-4) DMSFWT7 MT DTT DMSFWT7 MA Inhibitor DMSFWT7 RN Metabolism and bioactivation of famitinib, a novel inhibitor of receptor tyrosine kinase, in cancer patients. Br J Pharmacol. 2013 Apr;168(7):1687-706. DMSFWT7 RU https://pubmed.ncbi.nlm.nih.gov/23126373 DM563NC DI DM563NC DM563NC DN Fasitibant chloride DM563NC MI TTGY8IW DM563NC MN B2 bradykinin receptor (BDKRB2) DM563NC MT DTT DM563NC MA Antagonist DM563NC RN Fasitibant chloride, a kinin B receptor antagonist, and dexamethasone interact to inhibit carrageenan-induced inflammatory arthritis in rats. Br J Pharmacol. 2012 Jun;166(4):1403-10. DM563NC RU https://pubmed.ncbi.nlm.nih.gov/22251015 DMR3952 DI DMR3952 DMR3952 DN FBS-0701 DMR3952 MI TTQO71U DMR3952 MN Hemoglobin (HB) DMR3952 MT DTT DMR3952 MA Modulator DMR3952 RN A high-affinity fully human anti-IL-6 mAb, 1339, for the treatment of multiple myeloma. Clin Cancer Res. 2009 Dec 1;15(23):7144-52. DMR3952 RU https://pubmed.ncbi.nlm.nih.gov/22919029 DM3CVHQ DI DM3CVHQ DM3CVHQ DN FE-202158 DM3CVHQ MI TT4TFGN DM3CVHQ MN Vasopressin V1a receptor (V1AR) DM3CVHQ MT DTT DM3CVHQ MA Agonist DM3CVHQ RN The selective vasopressin type 1a receptor agonist selepressin (FE 202158) blocks vascular leak in ovine severe sepsis*. Crit Care Med. 2014 Jul;42(7):e525-33. DM3CVHQ RU https://pubmed.ncbi.nlm.nih.gov/24674922 DMDGZ1C DI DMDGZ1C DMDGZ1C DN FE-202767 DMDGZ1C MI TTSCIUP DMDGZ1C MN Oxytocin receptor (OTR) DMDGZ1C MT DTT DMDGZ1C MA Agonist DMDGZ1C RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 369). DMDGZ1C RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=369 DMICMXE DI DMICMXE DMICMXE DN Ferroquine DMICMXE MI DE5IED8 DMICMXE MN Cytochrome P450 2C9 (CYP2C9) DMICMXE MT DME DMICMXE MA Metabolism DMICMXE RN In vitro metabolism of ferroquine (SSR97193) in animal and human hepatic models and antimalarial activity of major metabolites on Plasmodium falciparum. Drug Metab Dispos. 2006 Apr;34(4):667-82. DMICMXE RU https://www.ncbi.nlm.nih.gov/pubmed/?term=16415117 DMICMXE DI DMICMXE DMICMXE DN Ferroquine DMICMXE MI DECB0K3 DMICMXE MN Cytochrome P450 2D6 (CYP2D6) DMICMXE MT DME DMICMXE MA Metabolism DMICMXE RN In vitro metabolism of ferroquine (SSR97193) in animal and human hepatic models and antimalarial activity of major metabolites on Plasmodium falciparum. Drug Metab Dispos. 2006 Apr;34(4):667-82. DMICMXE RU https://www.ncbi.nlm.nih.gov/pubmed/?term=16415117 DMICMXE DI DMICMXE DMICMXE DN Ferroquine DMICMXE MI DE4LYSA DMICMXE MN Cytochrome P450 3A4 (CYP3A4) DMICMXE MT DME DMICMXE MA Metabolism DMICMXE RN In vitro metabolism of ferroquine (SSR97193) in animal and human hepatic models and antimalarial activity of major metabolites on Plasmodium falciparum. Drug Metab Dispos. 2006 Apr;34(4):667-82. DMICMXE RU https://www.ncbi.nlm.nih.gov/pubmed/?term=16415117 DMICMXE DI DMICMXE DMICMXE DN Ferroquine DMICMXE MI TT0OV9N DMICMXE MN Haematin (HA) DMICMXE MT DTT DMICMXE MA Inhibitor DMICMXE RN Insights into the mechanism of action of ferroquine. Relationship between physicochemical properties and antiplasmodial activity. Mol Pharm. 2005 May-Jun;2(3):185-93. DMICMXE RU https://www.ncbi.nlm.nih.gov/pubmed/15934779 DMICMXE DI DMICMXE DMICMXE DN Ferroquine DMICMXE MI DEGTFWK DMICMXE MN Mephenytoin 4-hydroxylase (CYP2C19) DMICMXE MT DME DMICMXE MA Metabolism DMICMXE RN In vitro metabolism of ferroquine (SSR97193) in animal and human hepatic models and antimalarial activity of major metabolites on Plasmodium falciparum. Drug Metab Dispos. 2006 Apr;34(4):667-82. DMICMXE RU https://www.ncbi.nlm.nih.gov/pubmed/?term=16415117 DMJX2P4 DI DMJX2P4 DMJX2P4 DN Fezakinumab DMJX2P4 MI TTLDX4N DMJX2P4 MN Interleukin-22 (IL22) DMJX2P4 MT DTT DMJX2P4 RN Emerging Therapies for the Treatment of Psoriasis. Dermatol Ther (Heidelb) 2012 December; 2(1): 16. DMJX2P4 RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3510410/ DM7RYL4 DI DM7RYL4 DM7RYL4 DN FG-2216 DM7RYL4 MI TTJQFBG DM7RYL4 MN HIF-prolyl hydroxylase (HPH) DM7RYL4 MT DTT DM7RYL4 MA Modulator DM7RYL4 RN Inhibition of Prolyl Hydroxylases Increases Erythropoietin Production in ESRD DM7RYL4 RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3014028 DMXMC8I DI DMXMC8I DMXMC8I DN FGF-1 DMXMC8I MI TTRLW2X DMXMC8I MN Fibroblast growth factor receptor 1 (FGFR1) DMXMC8I MT DTT DMXMC8I MA Binder DMXMC8I RN Marimastat as maintenance therapy for patients with advanced gastric cancer: a randomised trial. Br J Cancer. 2002 Jun 17;86(12):1864-70. DMXMC8I RU https://pubmed.ncbi.nlm.nih.gov/12085177 DMCIGRB DI DMCIGRB DMCIGRB DN Fialuridine DMCIGRB MI TTIU7X1 DMCIGRB MN Herpes simplex virus DNA polymerase UL30 (HSV UL30) DMCIGRB MT DTT DMCIGRB MA Modulator DMCIGRB RN Fialuridine and its metabolites inhibit DNA polymerase gamma at sites of multiple adjacent analog incorporation, decrease mtDNA abundance, and cause mitochondrial structural defects in cultured hepatoblasts. Proc Natl Acad Sci U S A. 1996 Apr 16;93(8):3592-7. DMCIGRB RU https://pubmed.ncbi.nlm.nih.gov/8622980 DMG65WH DI DMG65WH DMG65WH DN Ficlatuzumab DMG65WH MI TT4V2JM DMG65WH MN Hepatocyte growth factor (HGF) DMG65WH MT DTT DMG65WH MA Inhibitor DMG65WH RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMG65WH RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DMNSYXB DI DMNSYXB DMNSYXB DN Filibuvir DMNSYXB MI TTMVBWH DMNSYXB MN Hepatitis C virus RNA-directed RNA polymerase (HCV NS5B) DMNSYXB MT DTT DMNSYXB MA Inhibitor DMNSYXB RN Clinical pipeline report, company report or official report of Pfizer (2011). DMNSYXB RU http://www.pfizer.com/home/ DMG439E DI DMG439E DMG439E DN Fipamezole DMG439E MI TTQ8AFT DMG439E MN Adrenergic receptor Alpha-2 (ADRA2) DMG439E MT DTT DMG439E MA Antagonist DMG439E RN Emerging drugs for Parkinson's disease. Expert Opin Emerg Drugs. 2006 Sep;11(3):403-17. DMG439E RU https://pubmed.ncbi.nlm.nih.gov/16939381 DMW2QYT DI DMW2QYT DMW2QYT DN Firategrast DMW2QYT MI TT6S84X DMW2QYT MN Integrin alpha-4/beta-1 (ITGA4/B1) DMW2QYT MT DTT DMW2QYT MA Modulator DMW2QYT RN Firategrast for relapsing remitting multiple sclerosis: a phase 2, randomised, double-blind, placebo-controlled trial.Lancet Neurol.2012 Feb;11(2):131-9. DMW2QYT RU https://www.ncbi.nlm.nih.gov/pubmed/22226929 DMJSD5W DI DMJSD5W DMJSD5W DN FK-070 DMJSD5W MI TT2O84V DMJSD5W MN Thromboxane A2 receptor (TBXA2R) DMJSD5W MT DTT DMJSD5W MA Modulator DMJSD5W RN Pharmacokinetic and pharmacodynamic properties of FK070 (KDI-792), a novel thromboxane receptor antagonist/thromboxane synthetase inhibitor, after single and multiple oral administrations to healthy volunteers. J Pharm Pharmacol. 1996 Apr;48(4):380-5. DMJSD5W RU https://pubmed.ncbi.nlm.nih.gov/8794987 DMJSD5W DI DMJSD5W DMJSD5W DN FK-070 DMJSD5W MI TTKNWZ4 DMJSD5W MN Thromboxane-A synthase (TBXAS1) DMJSD5W MT DTT DMJSD5W MA Modulator DMJSD5W RN Pharmacokinetic and pharmacodynamic properties of FK070 (KDI-792), a novel thromboxane receptor antagonist/thromboxane synthetase inhibitor, after single and multiple oral administrations to healthy volunteers. J Pharm Pharmacol. 1996 Apr;48(4):380-5. DMJSD5W RU https://pubmed.ncbi.nlm.nih.gov/8794987 DMEL15U DI DMEL15U DMEL15U DN FK-143 DMEL15U MI TT2A0DR DMEL15U MN Oxo-5-alpha-steroid 4-dehydrogenase (SRD5A) DMEL15U MT DTT DMEL15U MA Modulator DMEL15U RN FK143, a novel nonsteroidal inhibitor of steroid 5 alpha-reductase: (1) In vitro effects on human and animal prostatic enzymes. J Steroid Biochem Mol Biol. 1995 Apr;52(4):357-63. DMEL15U RU https://www.ncbi.nlm.nih.gov/pubmed/7734404 DML5AE4 DI DML5AE4 DML5AE4 DN FK-3311 DML5AE4 MI TTVKILB DML5AE4 MN Prostaglandin G/H synthase 2 (COX-2) DML5AE4 MT DTT DML5AE4 MA Modulator DML5AE4 RN Effects of the COX-2 inhibitor FK3311 on ischemia - reperfusion injury in the rat lung. J Invest Surg. 2007 May-Jun;20(3):175-80. DML5AE4 RU https://pubmed.ncbi.nlm.nih.gov/17613692 DMKVXYS DI DMKVXYS DMKVXYS DN FK-409 DMKVXYS MI TTWNFC2 DMKVXYS MN Soluble guanylyl cyclase (GUCY2D) DMKVXYS MT DTT DMKVXYS MA Modulator DMKVXYS RN Vasorelaxant mechanism of the new vasodilator, FK409. Eur J Pharmacol. 1993 Aug 15;246(3):205-12. DMKVXYS RU https://www.ncbi.nlm.nih.gov/pubmed/7901040 DMGROQP DI DMGROQP DMGROQP DN FK-505 DMGROQP MI TTFH2RS DMGROQP MN FK506-binding protein (FKBP) DMGROQP MT DTT DMGROQP MA Modulator DMGROQP RN Prevention of Cardiac Hypertrophy by Calcineurin Inhibition. Circulation Research. 1999; 84: 623-632. DMGROQP RU http://circres.ahajournals.org/content/84/6/623.full.html DMY61TJ DI DMY61TJ DMY61TJ DN FK-614 DMY61TJ MI TTZMAO3 DMY61TJ MN Peroxisome proliferator-activated receptor gamma (PPAR-gamma) DMY61TJ MT DTT DMY61TJ MA Agonist DMY61TJ RN FK-614, a selective peroxisome proliferator-activated receptor gamma agonist, improves peripheral glucose utilization while decreasing hepatic insulin extraction in alloxan-induced diabetic dogs. Metabolism. 2005 Sep;54(9):1250-8. DMY61TJ RU https://pubmed.ncbi.nlm.nih.gov/16125538 DMV0MZ3 DI DMV0MZ3 DMV0MZ3 DN FK-962 DMV0MZ3 MI TTOMNR9 DMV0MZ3 MN Somatostatin receptor (SSTR) DMV0MZ3 MT DTT DMV0MZ3 MA Modulator DMV0MZ3 RN FK960, a novel potential anti-dementia drug, enhances high K(+)-evoked release of somatostatin from rat hippocampal slices. Brain Res. 2001 Feb 16;892(1):111-7. DMV0MZ3 RU https://www.ncbi.nlm.nih.gov/pubmed/11172755 DM2O7NM DI DM2O7NM DM2O7NM DN FKB01MD DM2O7NM MI TTSQIFT DM2O7NM MN 5-HT 1A receptor (HTR1A) DM2O7NM MT DTT DM2O7NM MA Modulator DM2O7NM RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DM2O7NM RU http://phrma-docs.phrma.org/files/dmfile/MID_Mental-Illness-2017-Drug-List_Final.pdf DM2O7NM DI DM2O7NM DM2O7NM DN FKB01MD DM2O7NM MI TT6MSOK DM2O7NM MN 5-HT 1D receptor (HTR1D) DM2O7NM MT DTT DM2O7NM MA Agonist DM2O7NM RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DM2O7NM RU http://phrma-docs.phrma.org/files/dmfile/MID_Mental-Illness-2017-Drug-List_Final.pdf DM2O7NM DI DM2O7NM DM2O7NM DN FKB01MD DM2O7NM MI TTYSN63 DM2O7NM MN 5-HT 2 receptor (5HT2R) DM2O7NM MT DTT DM2O7NM MA Inhibitor DM2O7NM RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DM2O7NM RU http://phrma-docs.phrma.org/files/dmfile/MID_Mental-Illness-2017-Drug-List_Final.pdf DMPXH7N DI DMPXH7N DMPXH7N DN FKW00GA DMPXH7N MI TTSQIFT DMPXH7N MN 5-HT 1A receptor (HTR1A) DMPXH7N MT DTT DMPXH7N MA Antagonist DMPXH7N RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMPXH7N RU http://phrma-docs.phrma.org/files/dmfile/MID_Mental-Illness-2017-Drug-List_Final.pdf DMPXH7N DI DMPXH7N DMPXH7N DN FKW00GA DMPXH7N MI TTJQOD7 DMPXH7N MN 5-HT 2A receptor (HTR2A) DMPXH7N MT DTT DMPXH7N MA Antagonist DMPXH7N RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMPXH7N RU http://phrma-docs.phrma.org/files/dmfile/MID_Mental-Illness-2017-Drug-List_Final.pdf DMKSUOI DI DMKSUOI DMKSUOI DN Flavopiridol DMKSUOI MI DTI7UX6 DMKSUOI MN Breast cancer resistance protein (ABCG2) DMKSUOI MT DTP DMKSUOI MA Substrate DMKSUOI RN The novel BCR-ABL and FLT3 inhibitor ponatinib is a potent inhibitor of the MDR-associated ATP-binding cassette transporter ABCG2. Mol Cancer Ther. 2012 Sep;11(9):2033-44. DMKSUOI RU http://www.ncbi.nlm.nih.gov/pubmed/22778153 DMKSUOI DI DMKSUOI DMKSUOI DN Flavopiridol DMKSUOI MI TTMBO1Z DMKSUOI MN Cyclin-dependent kinase (CDK) DMKSUOI MT DTT DMKSUOI MA Inhibitor DMKSUOI RN Pharma & Vaccines. Product Development Pipeline. April 29 2009. DMKSUOI RU http://en.sanofi-aventis.com/binaries/RD_Phase_III_EN_tcm28-24007.pdf DMKSUOI DI DMKSUOI DMKSUOI DN Flavopiridol DMKSUOI MI TT1LVF2 DMKSUOI MN Cyclin-dependent kinase 9 (CDK9) DMKSUOI MT DTT DMKSUOI MA Inhibitor DMKSUOI RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMKSUOI RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DMKSUOI DI DMKSUOI DMKSUOI DN Flavopiridol DMKSUOI MI TT31JXP DMKSUOI MN Myophosphorylase (PYGM) DMKSUOI MT DTT DMKSUOI MA Inhibitor DMKSUOI RN Pharma & Vaccines. Product Development Pipeline. April 29 2009. DMKSUOI RU http://en.sanofi-aventis.com/binaries/RD_Phase_III_EN_tcm28-24007.pdf DMKSUOI DI DMKSUOI DMKSUOI DN Flavopiridol DMKSUOI MI DT3D8F0 DMKSUOI MN Organic anion transporting polypeptide 1B1 (SLCO1B1) DMKSUOI MT DTP DMKSUOI MA Substrate DMKSUOI RN Organic anion transporting polypeptide 1B1: a genetically polymorphic transporter of major importance for hepatic drug uptake. Pharmacol Rev. 2011 Mar;63(1):157-81. DMKSUOI RU http://www.ncbi.nlm.nih.gov/pubmed/21245207 DMKSUOI DI DMKSUOI DMKSUOI DN Flavopiridol DMKSUOI MI DEYGVN4 DMKSUOI MN UDP-glucuronosyltransferase 1A1 (UGT1A1) DMKSUOI MT DME DMKSUOI MA Metabolism DMKSUOI RN Drug-drug interactions for UDP-glucuronosyltransferase substrates: a pharmacokinetic explanation for typically observed low exposure (AUCi/AUC) ratios. Drug Metab Dispos. 2004 Nov;32(11):1201-8. DMKSUOI RU https://www.ncbi.nlm.nih.gov/pubmed/?term=15304429 DMCN4H6 DI DMCN4H6 DMCN4H6 DN Flezelastine DMCN4H6 MI TTEWNM1 DMCN4H6 MN IL-1 synthesis/release (IL-1 synth/rele) DMCN4H6 MT DTT DMCN4H6 MA Modulator DMCN4H6 RN Effects of flezelastine and its enantiomers on LPS-induced IL-1 beta generation in vitro and LPS-induced pyrexia in vivo. Agents Actions. 1994 Mar;41(1-2):99-100. DMCN4H6 RU https://pubmed.ncbi.nlm.nih.gov/7915872 DMVR6OM DI DMVR6OM DMVR6OM DN Flotetuzumab DMVR6OM MI TTENHJ0 DMVR6OM MN Interleukin 3 receptor alpha (IL3RA) DMVR6OM MT DTT DMVR6OM RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMVR6OM RU http://phrma-docs.phrma.org/files/dmfile/MID_Immuno-Oncology-2017_Drug-List1.pdf DMMQ1YU DI DMMQ1YU DMMQ1YU DN FLUASTERONE DMMQ1YU MI TT3V81G DMMQ1YU MN Nuclear receptor unspecific (NR) DMMQ1YU MT DTT DMMQ1YU MA Modulator DMMQ1YU RN Dehydroepiandrosterone activates endothelial cell nitric-oxide synthase by a specific plasma membrane receptor coupled to Galpha(i2,3). J Biol Chem. 2002 Jun 14;277(24):21379-88. DMMQ1YU RU https://pubmed.ncbi.nlm.nih.gov/11934890 DME01HT DI DME01HT DME01HT DN Fluciclatide F-18 DME01HT MI TT69TQN DME01HT MN Integrin alpha-V/beta-3 (ITGAV/B3) DME01HT MT DTT DME01HT MA Modulator DME01HT RN Use of a novel Arg-Gly-Asp radioligand, 18F-AH111585, to determine changes in tumor vascularity after antitumor therapy.J Nucl Med.2009 Jan;50(1):116-22. DME01HT RU https://www.ncbi.nlm.nih.gov/pubmed/19091899 DM0G5O6 DI DM0G5O6 DM0G5O6 DN Flumatinib DM0G5O6 MI TT3PJMV DM0G5O6 MN Tyrosine-protein kinase ABL1 (ABL) DM0G5O6 MT DTT DM0G5O6 MA Inhibitor DM0G5O6 RN Flumatinib, a selective inhibitor of BCR-ABL/PDGFR/KIT, effectively overcomes drug resistance of certain KIT mutants. Cancer Sci. 2014 Jan;105(1):117-25. DM0G5O6 RU https://pubmed.ncbi.nlm.nih.gov/24205792 DMCEUOH DI DMCEUOH DMCEUOH DN Fluoropeptide vaccine DMCEUOH MI TTN2JFW DMCEUOH MN T-cell surface glycoprotein CD4 (CD4) DMCEUOH MT DTT DMCEUOH RN A novel peptide-based pan-influenza A vaccine: a double blind, randomised clinical trial of immunogenicity and safety. Vaccine. 2015 Jan 3;33(2):396-402. DMCEUOH RU https://pubmed.ncbi.nlm.nih.gov/24928790 DMCEUOH DI DMCEUOH DMCEUOH DN Fluoropeptide vaccine DMCEUOH MI TTMHA6L DMCEUOH MN T-cell surface glycoprotein CD8 (CD8) DMCEUOH MT DTT DMCEUOH RN A novel peptide-based pan-influenza A vaccine: a double blind, randomised clinical trial of immunogenicity and safety. Vaccine. 2015 Jan 3;33(2):396-402. DMCEUOH RU https://pubmed.ncbi.nlm.nih.gov/24928790 DMPBV9D DI DMPBV9D DMPBV9D DN Flupirtine DMPBV9D MI TTQ29KF DMPBV9D MN Voltage-gated potassium channel Kv7 (KCNQ) DMPBV9D MT DTT DMPBV9D MA Modulator DMPBV9D RN Treatment with the Kv7 potassium channel activator flupirtine is beneficial in two independent mouse models of pulmonary hypertension. Br J Pharmacol. 2009 August; 157(7): 1241-1249. DMPBV9D RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2743843/ DMQX5UA DI DMQX5UA DMQX5UA DN FLX-787 DMQX5UA MI TTFRV98 DMQX5UA MN Melanoma antigen gp75 (TYRP1) DMQX5UA MT DTT DMQX5UA MA Activator DMQX5UA RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMQX5UA RU http://phrma-docs.phrma.org/files/dmfile/medicines-in-development-drug-list-autoimmune-diseases.pdf DMQX5UA DI DMQX5UA DMQX5UA DN FLX-787 DMQX5UA MI TT79AOF DMQX5UA MN Transient receptor potential channel (TRP channel) DMQX5UA MT DTT DMQX5UA MA Agonist DMQX5UA RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMQX5UA RU http://phrma-docs.phrma.org/files/dmfile/MID_Neurological-Disorders-Drug-List_2018.pdf DMB9ADM DI DMB9ADM DMB9ADM DN FolateImmune DMB9ADM MI TTVC37M DMB9ADM MN Folate receptor alpha (FOLR1) DMB9ADM MT DTT DMB9ADM MA Modulator DMB9ADM RN Responsiveness of the Effective Consumer Scale (EC-17). J Rheumatol. 2009 Sep;36(9):2087-91. DMB9ADM RU https://pubmed.ncbi.nlm.nih.gov/19738218 DMJNO3D DI DMJNO3D DMJNO3D DN Follicle stimulating hormone DMJNO3D MI TT13GFV DMJNO3D MN Follicle stimulating hormone (FSHB) DMJNO3D MT DTT DMJNO3D MA Modulator DMJNO3D RN Company report (Glycotope) DMJNO3D RU http://www.glycotope.com/glycotopes-fully-human-and-glycooptimized-recombinant-fsh-gextm-showed-superior-activity-and-excellent-tolerability-in-a-phase-ii-clinical-trial-for-in-vitro-fertilisation DMUAXS5 DI DMUAXS5 DMUAXS5 DN FP-1039 DMUAXS5 MI TTRLW2X DMUAXS5 MN Fibroblast growth factor receptor 1 (FGFR1) DMUAXS5 MT DTT DMUAXS5 MA Antagonist DMUAXS5 RN FGF1-gold nanoparticle conjugates targeting FGFR efficiently decrease cell viability upon NIR irradiation. Int J Nanomedicine. 2012; 7: 5915-5927. DMUAXS5 RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3514973/ DMC1F2T DI DMC1F2T DMC1F2T DN FP-1097 DMC1F2T MI TTZ9SOR DMC1F2T MN Muscarinic acetylcholine receptor M1 (CHRM1) DMC1F2T MT DTT DMC1F2T MA Antagonist DMC1F2T RN Clinical pipeline report, company report or official report of FemmePharma. DMC1F2T RU http://femmepharma.com/ DMC1F2T DI DMC1F2T DMC1F2T DN FP-1097 DMC1F2T MI TTYEG6Q DMC1F2T MN Muscarinic acetylcholine receptor M2 (CHRM2) DMC1F2T MT DTT DMC1F2T MA Antagonist DMC1F2T RN Clinical pipeline report, company report or official report of FemmePharma. DMC1F2T RU http://femmepharma.com/ DMXOTMP DI DMXOTMP DMXOTMP DN FPI-01 DMXOTMP MI TTZ8UT4 DMXOTMP MN Wilms tumor protein (WT1) DMXOTMP MT DTT DMXOTMP RN Clinical pipeline report, company report or official report of Formula Pharmaceuticals. DMXOTMP RU http://www.formulapharma.com/fp1_01/default.asp DMEL5SV DI DMEL5SV DMEL5SV DN FR139317 DMEL5SV MI TTKRD0G DMEL5SV MN Endothelin A receptor (EDNRA) DMEL5SV MT DTT DMEL5SV MA Antagonist DMEL5SV RN Reduction of bFGF-induced smooth muscle cell proliferation and endothelin receptor mRNA expression by mevastatin and atorvastatin. Biochem Pharmacol. 2002 Aug 1;64(3):497-505. DMEL5SV RU https://pubmed.ncbi.nlm.nih.gov/12147302 DMEL5SV DI DMEL5SV DMEL5SV DN FR139317 DMEL5SV MI TTZPO1L DMEL5SV MN Substance-P receptor (TACR1) DMEL5SV MT DTT DMEL5SV MA Antagonist DMEL5SV RN Clinical pipeline report, company report or official report of GlaxoSmithKline (2009). DMEL5SV RU http://www.gsk.com/investors/product_pipeline/docs/gsk-pipeline-feb09.pdf DMGO45I DI DMGO45I DMGO45I DN FR-146687 DMGO45I MI TTTU72V DMGO45I MN Steroid 5-alpha-reductase 1 (SRD5A1) DMGO45I MT DTT DMGO45I MA Inhibitor DMGO45I RN Pharmacokinetics and pharmacodynamics of TF-505, a novel nonsteroidal 5alpha-reductase inhibitor, in normal subjects treated with single or multiple doses. Br J Clin Pharmacol. 2002 Sep;54(3):283-94. DMGO45I RU https://pubmed.ncbi.nlm.nih.gov/12236849 DMFZ084 DI DMFZ084 DMFZ084 DN Fresolimumab DMFZ084 MI TTO3HT7 DMFZ084 MN Transforming growth factor beta (TGFB) DMFZ084 MT DTT DMFZ084 MA Inhibitor DMFZ084 RN Focal Irradiation and Systemic TGF Blockade in Metastatic Breast Cancer. Clin Cancer Res. 2018 Jun 1;24(11):2493-2504. DMFZ084 RU https://pubmed.ncbi.nlm.nih.gov/29476019 DM9ORUW DI DM9ORUW DM9ORUW DN FRM-0962 DM9ORUW MI TTE4KHA DM9ORUW MN Amyloid beta A4 protein (APP) DM9ORUW MT DTT DM9ORUW MA Modulator DM9ORUW RN Gamma-secretase. SciBX 7(40); doi:10.1038/scibx.2014.1175. Oct. 16 2014 DM9ORUW RU http://www.nature.com/scibx/journal/v7/n40/full/scibx.2014.1175.html DMZLBAW DI DMZLBAW DMZLBAW DN Fucoxanthin DMZLBAW MI TTSHAEB DMZLBAW MN NF-kappa-B inhibitor alpha (NFKBIA) DMZLBAW MT DTT DMZLBAW MA Inhibitor DMZLBAW RN Fucoxanthin inhibits the inflammatory response by suppressing the activation of NF-B and MAPKs in lipopolysaccharide-induced RAW 264.7 macrophages. Eur J Pharmacol. 2010 Dec 15;649(1-3):369-75. DMZLBAW RU https://pubmed.ncbi.nlm.nih.gov/20868674 DMPQFTA DI DMPQFTA DMPQFTA DN Fucoxanthin DMPQFTA MI DTUGYRD DMPQFTA MN P-glycoprotein 1 (ABCB1) DMPQFTA MT DTP DMPQFTA MA Substrate DMPQFTA RN Carotenoids reverse multidrug resistance in cancer cells by interfering with ABC-transporters. Phytomedicine. 2012 Aug 15;19(11):977-87. DMPQFTA RU https://doi.org/10.1016/j.phymed.2012.05.010 DMKHNXA DI DMKHNXA DMKHNXA DN G100 DMKHNXA MI TTISGCA DMKHNXA MN Toll-like receptor 4 (TLR4) DMKHNXA MT DTT DMKHNXA MA Antagonist DMKHNXA RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMKHNXA RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DMQO2IT DI DMQO2IT DMQO2IT DN G1T38 DMQO2IT MI TT0PG8F DMQO2IT MN Cyclin-dependent kinase 4 (CDK4) DMQO2IT MT DTT DMQO2IT MA Inhibitor DMQO2IT RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMQO2IT RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DMQO2IT DI DMQO2IT DMQO2IT DN G1T38 DMQO2IT MI TTO0FDJ DMQO2IT MN Cyclin-dependent kinase 6 (CDK6) DMQO2IT MT DTT DMQO2IT MA Inhibitor DMQO2IT RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMQO2IT RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DMQR9I8 DI DMQR9I8 DMQR9I8 DN G-202 DMQR9I8 MI TT9G4N0 DMQR9I8 MN Glutamate carboxypeptidase II (GCPII) DMQR9I8 MT DTT DMQR9I8 MA Inhibitor DMQR9I8 RN National Cancer Institute Drug Dictionary (drug id 666090). DMQR9I8 RU http://www.cancer.gov/publications/dictionaries/cancer-drug?cdrid=666090 DMJY2TM DI DMJY2TM DMJY2TM DN Gabapentin enacarbil DMJY2TM MI DT342ZG DMJY2TM MN Monocarboxylate transporter 1 (SLC16A1) DMJY2TM MT DTP DMJY2TM MA Substrate DMJY2TM RN Overview of the proton-coupled MCT (SLC16A) family of transporters: characterization, function and role in the transport of the drug of abuse gamma-hydroxybutyric acid. AAPS J. 2008 Jun;10(2):311-21. DMJY2TM RU https://doi.org/10.1208/s12248-008-9035-6 DMJY2TM DI DMJY2TM DMJY2TM DN Gabapentin enacarbil DMJY2TM MI DTE3TAW DMJY2TM MN Sodium-coupled monocarboxylate transporter 1 (SLC5A8) DMJY2TM MT DTP DMJY2TM MA Substrate DMJY2TM RN Clinical pharmacokinetic drug interaction studies of gabapentin enacarbil, a novel transported prodrug of gabapentin, with naproxen and cimetidine. Br J Clin Pharmacol. 2010 May;69(5):498-507. DMJY2TM RU http://www.ncbi.nlm.nih.gov/pubmed/20573085 DMJY2TM DI DMJY2TM DMJY2TM DN Gabapentin enacarbil DMJY2TM MI TT61XTV DMJY2TM MN Sodium-dependent multivitamin transporter (SLC5A6) DMJY2TM MT DTT DMJY2TM MA Modulator DMJY2TM RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. DMJY2TM RU https://www.fda.gov/ DMJY2TM DI DMJY2TM DMJY2TM DN Gabapentin enacarbil DMJY2TM MI DTD5Y4G DMJY2TM MN Sodium-dependent multivitamin transporter (SLC5A6) DMJY2TM MT DTP DMJY2TM MA Substrate DMJY2TM RN Clinical pharmacokinetic drug interaction studies of gabapentin enacarbil, a novel transported prodrug of gabapentin, with naproxen and cimetidine. Br J Clin Pharmacol. 2010 May;69(5):498-507. DMJY2TM RU http://www.ncbi.nlm.nih.gov/pubmed/20573085 DMTXCUS DI DMTXCUS DMTXCUS DN Galiximab DMTXCUS MI TTFZDNP DMTXCUS MN Activation B7-1 antigen (CD80) DMTXCUS MT DTT DMTXCUS RN Phase I/II study of galiximab, an anti-CD80 antibody, for relapsed or refractory follicular lymphoma. J Clin Oncol. 2005 Jul 1;23(19):4390-8. DMTXCUS RU https://pubmed.ncbi.nlm.nih.gov/15994148 DMXBR27 DI DMXBR27 DMXBR27 DN Gallopamil DMXBR27 MI TTL69WB DMXBR27 MN Angiotensin-converting enzyme (ACE) DMXBR27 MT DTT DMXBR27 MA Inhibitor DMXBR27 RN Mechanism of vasopeptidase inhibitor-induced plasma extravasation: comparison of omapatrilat and the novel neutral endopeptidase 24.11/angiotensin-converting enzyme inhibitor GW796406. J Pharmacol Exp Ther. 2005 Dec;315(3):1306-13. DMXBR27 RU https://pubmed.ncbi.nlm.nih.gov/16144980 DMXBR27 DI DMXBR27 DMXBR27 DN Gallopamil DMXBR27 MI DE4LYSA DMXBR27 MN Cytochrome P450 3A4 (CYP3A4) DMXBR27 MT DME DMXBR27 MA Metabolism DMXBR27 RN Identification of human cytochrome P-450 isoforms involved in metabolism of R(+)- and S(-)-gallopamil: utility of in vitro disappearance rate. Drug Metab Dispos. 1999 Nov;27(11):1254-9. DMXBR27 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=10534309 DMXBR27 DI DMXBR27 DMXBR27 DN Gallopamil DMXBR27 MI TT5TKPM DMXBR27 MN Neutral endopeptidase (MME) DMXBR27 MT DTT DMXBR27 MA Inhibitor DMXBR27 RN Mechanism of vasopeptidase inhibitor-induced plasma extravasation: comparison of omapatrilat and the novel neutral endopeptidase 24.11/angiotensin-converting enzyme inhibitor GW796406. J Pharmacol Exp Ther. 2005 Dec;315(3):1306-13. DMXBR27 RU https://pubmed.ncbi.nlm.nih.gov/16144980 DMXBR27 DI DMXBR27 DMXBR27 DN Gallopamil DMXBR27 MI DTUGYRD DMXBR27 MN P-glycoprotein 1 (ABCB1) DMXBR27 MT DTP DMXBR27 MA Substrate DMXBR27 RN Human intestinal transporter database: QSAR modeling and virtual profiling of drug uptake, efflux and interactions. Pharm Res. 2013 Apr;30(4):996-1007. DMXBR27 RU https://doi.org/10.1007/s11095-012-0935-x DMXBR27 DI DMXBR27 DMXBR27 DN Gallopamil DMXBR27 MI TTE6THL DMXBR27 MN Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 (ATP2A2) DMXBR27 MT DTT DMXBR27 MA Inhibitor DMXBR27 RN Interaction of D-600 with the transmembrane domain of the sarcoplasmic reticulum Ca(2+)-ATPase. Am J Physiol Cell Physiol. 2000 Jul;279(1):C166-72. DMXBR27 RU https://pubmed.ncbi.nlm.nih.gov/10898728 DMXBR27 DI DMXBR27 DMXBR27 DN Gallopamil DMXBR27 MI TTXHYV6 DMXBR27 MN Voltage-gated L-type calcium channel (L-CaC) DMXBR27 MT DTT DMXBR27 MA Blocker DMXBR27 RN Role of apoptosis in the kidney after reperfusion. Orv Hetil. 2008 Feb 17;149(7):305-15. DMXBR27 RU https://pubmed.ncbi.nlm.nih.gov/18258561 DMAEWS1 DI DMAEWS1 DMAEWS1 DN GAM-501 DMAEWS1 MI TTQA6SX DMAEWS1 MN Platelet-derived growth factor B (PDGFB) DMAEWS1 MT DTT DMAEWS1 MA Modulator DMAEWS1 RN Treatment of nonhealing diabetic foot ulcers with a platelet-derived growth factor gene-activated matrix (GAM501): results of a phase 1/2 trial. Wound Repair Regen. 2009 Nov-Dec;17(6):772-9. DMAEWS1 RU https://pubmed.ncbi.nlm.nih.gov/19821960 DM2IFJQ DI DM2IFJQ DM2IFJQ DN GBL-310 DM2IFJQ MI TTVOE6D DM2IFJQ MN Mitogen-activated protein kinase (MAPK) DM2IFJQ MT DTT DM2IFJQ MA Inhibitor DM2IFJQ RN WO patent application no. 2010,0456,51, Methods for analyzing drug response. DM2IFJQ RU http://worldwide.espacenet.com/publicationDetails/biblio?DB=worldwide.espacenet.com&II=0&ND=3&adjacent=true&locale=en_EP&FT=D&date=20100422&CC=WO&NR=2010045651A1&KC=A1 DM2VO9T DI DM2VO9T DM2VO9T DN GBR 830 DM2VO9T MI TTL31H0 DM2VO9T MN OX40L receptor (CD134) DM2VO9T MT DTT DM2VO9T MA Antagonist DM2VO9T RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DM2VO9T RU http://phrma-docs.phrma.org/files/dmfile/MID_Skin_Diseases_2018_9_FINAL.pdf DMYS6MW DI DMYS6MW DMYS6MW DN GCS-100 DMYS6MW MI TTX1OI0 DMYS6MW MN Galectin (LGALS) DMYS6MW MT DTT DMYS6MW MA Modulator DMYS6MW RN GCS-100, a novel galectin-3 antagonist, modulates MCL-1, NOXA, and cell cycle to induce myeloma cell death. Blood. 2010 May 13;115(19):3939-48. DMYS6MW RU https://pubmed.ncbi.nlm.nih.gov/20190189 DMY6WUV DI DMY6WUV DMY6WUV DN GDC-0077 DMY6WUV MI TTHBTOP DMY6WUV MN PI3-kinase gamma (PIK3CG) DMY6WUV MT DTT DMY6WUV MA Inhibitor DMY6WUV RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMY6WUV RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DMA9SEY DI DMA9SEY DMA9SEY DN GDC-0084 DMA9SEY MI TTHBTOP DMA9SEY MN PI3-kinase gamma (PIK3CG) DMA9SEY MT DTT DMA9SEY MA Inhibitor DMA9SEY RN Current clinical development of PI3K pathway inhibitors in glioblastoma. Neuro Oncol. 2012 July; 14(7): 819-829. DMA9SEY RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3379803/ DM1YAK6 DI DM1YAK6 DM1YAK6 DN GDC0941 DM1YAK6 MI TTHBTOP DM1YAK6 MN PI3-kinase gamma (PIK3CG) DM1YAK6 MT DTT DM1YAK6 MA Inhibitor DM1YAK6 RN Targeting the phosphoinositide 3-kinase pathway in cancer. Nat Rev Drug Discov. 2009 Aug;8(8):627-44. DM1YAK6 RU https://pubmed.ncbi.nlm.nih.gov/19644473 DMF3MV1 DI DMF3MV1 DMF3MV1 DN GDC-0980/RG7422 DMF3MV1 MI TTHBTOP DMF3MV1 MN PI3-kinase gamma (PIK3CG) DMF3MV1 MT DTT DMF3MV1 MA Modulator DMF3MV1 RN GDC-0980 is a novel class I PI3K/mTOR kinase inhibitor with robust activity in cancer models driven by the PI3K pathway. Mol Cancer Ther. 2011 Dec;10(12):2426-36. DMF3MV1 RU https://pubmed.ncbi.nlm.nih.gov/21998291 DMF3MV1 DI DMF3MV1 DMF3MV1 DN GDC-0980/RG7422 DMF3MV1 MI TTCJG29 DMF3MV1 MN Serine/threonine-protein kinase mTOR (mTOR) DMF3MV1 MT DTT DMF3MV1 MA Modulator DMF3MV1 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2109). DMF3MV1 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2109 DMMQY0O DI DMMQY0O DMMQY0O DN GED-0507-34-Levo DMMQY0O MI TTZMAO3 DMMQY0O MN Peroxisome proliferator-activated receptor gamma (PPAR-gamma) DMMQY0O MT DTT DMMQY0O MA Agonist DMMQY0O RN PPAR-gamma in ulcerative colitis: a novel target for intervention. Curr Drug Targets. 2013 Nov;14(12):1501-7. DMMQY0O RU https://pubmed.ncbi.nlm.nih.gov/23651165 DMJN09S DI DMJN09S DMJN09S DN GEN-1 DMJN09S MI TTG68FB DMJN09S MN Interleukine 12 (IL-12) DMJN09S MT DTT DMJN09S MA Replacement DMJN09S RN Clinical pipeline report, company report or official report of Celsion. DMJN09S RU https://celsion.com/gen-1/ DMO9WU8 DI DMO9WU8 DMO9WU8 DN Gepirone DMO9WU8 MI DTUGYRD DMO9WU8 MN P-glycoprotein 1 (ABCB1) DMO9WU8 MT DTP DMO9WU8 MA Substrate DMO9WU8 RN Human intestinal transporter database: QSAR modeling and virtual profiling of drug uptake, efflux and interactions. Pharm Res. 2013 Apr;30(4):996-1007. DMO9WU8 RU https://doi.org/10.1007/s11095-012-0935-x DMD3RU8 DI DMD3RU8 DMD3RU8 DN GFT14 DMD3RU8 MI TTJ584C DMD3RU8 MN Peroxisome proliferator-activated receptor alpha (PPARA) DMD3RU8 MT DTT DMD3RU8 MA Agonist DMD3RU8 RN Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800024296) DMD3RU8 RU http://adisinsight.springer.com/drugs/800024296 DMTY4PG DI DMTY4PG DMTY4PG DN GI-4000 DMTY4PG MI TTW2R9X DMTY4PG MN GTPase NRas (NRAS) DMTY4PG MT DTT DMTY4PG RN Phase II study of the GI-4000 KRAS vaccine after curative therapy in patients with stage I-III lung adenocarcinoma harboring a KRAS G12C, G12D, or G12V mutation. Clin Lung Cancer. 2014 Nov;15(6):405-10. DMTY4PG RU https://pubmed.ncbi.nlm.nih.gov/25044103 DMQ0XZE DI DMQ0XZE DMQ0XZE DN GI-4000 + gemcitabine DMQ0XZE MI TTRHMTC DMQ0XZE MN Mutated KRAS (mKRAS) DMQ0XZE MT DTT DMQ0XZE MA Modulator DMQ0XZE RN Clinical pipeline report, company report or official report of GlobeImmune. DMQ0XZE RU https://www.globeimmune.com/cancer/gi-4000/ DM72O6F DI DM72O6F DM72O6F DN GI-6207 DM72O6F MI TTY6DTE DM72O6F MN Carcinoembryonic antigen CEA (CD66e) DM72O6F MT DTT DM72O6F MA Modulator DM72O6F RN Clinical pipeline report, company report or official report of GlobeImmune. DM72O6F RU https://www.globeimmune.com/cancer/gi-6207/ DMOMS7R DI DMOMS7R DMOMS7R DN GI-6301 DMOMS7R MI TTBXAHS DMOMS7R MN T-box transcription factor T (TBXT) DMOMS7R MT DTT DMOMS7R RN Clinical pipeline report, company report or official report of GlobeImmune. DMOMS7R RU https://www.globeimmune.com/cancer/gi-6301/ DMSKMET DI DMSKMET DMSKMET DN Gimatecan DMSKMET MI DTI7UX6 DMSKMET MN Breast cancer resistance protein (ABCG2) DMSKMET MT DTP DMSKMET MA Substrate DMSKMET RN Pharmacogenomic importance of ABCG2. Pharmacogenomics. 2008 Aug;9(8):1005-9. DMSKMET RU https://doi.org/10.2217/14622416.9.8.1005 DMSKMET DI DMSKMET DMSKMET DN Gimatecan DMSKMET MI TTGTQHC DMSKMET MN DNA topoisomerase I (TOP1) DMSKMET MT DTT DMSKMET MA Inhibitor DMSKMET RN Gimatecan and other camptothecin derivatives poison Leishmania DNA-topoisomerase IB leading to a strong leishmanicidal effect. Biochem Pharmacol. 2013 May 15;85(10):1433-40. DMSKMET RU https://pubmed.ncbi.nlm.nih.gov/23466420 DMSKMET DI DMSKMET DMSKMET DN Gimatecan DMSKMET MI DT3D8F0 DMSKMET MN Organic anion transporting polypeptide 1B1 (SLCO1B1) DMSKMET MT DTP DMSKMET MA Substrate DMSKMET RN Organic anion transporting polypeptide 1B1: a genetically polymorphic transporter of major importance for hepatic drug uptake. Pharmacol Rev. 2011 Mar;63(1):157-81. DMSKMET RU http://www.ncbi.nlm.nih.gov/pubmed/21245207 DMG3O2Z DI DMG3O2Z DMG3O2Z DN Girentuximab I-124 DMG3O2Z MI TT2LVK8 DMG3O2Z MN Carbonic anhydrase IX (CA-IX) DMG3O2Z MT DTT DMG3O2Z MA Enhancer DMG3O2Z RN Potential role of (124)I-girentuximab in the presurgical diagnosis of clear-cell renal cell cancer. Biologics. 2012;6:395-407. DMG3O2Z RU https://pubmed.ncbi.nlm.nih.gov/23204838 DMLFSMX DI DMLFSMX DMLFSMX DN GK1-399 DMLFSMX MI TTDLNGZ DMLFSMX MN Glucokinase (GCK) DMLFSMX MT DTT DMLFSMX MA Inhibitor DMLFSMX RN Clinical pipeline report, company report or official report of vTv Therapeutics, NCT02405260. DMLFSMX RU http://vtvtherapeutics.com/pipeline/ttp399 DMOVB3Y DI DMOVB3Y DMOVB3Y DN GKT-137831 DMOVB3Y MI TTFQVUT DMOVB3Y MN NADPH oxidase (NOX) DMOVB3Y MT DTT DMOVB3Y MA Modulator DMOVB3Y RN Nicotinamide Adenine Dinucleotide Phosphate Oxidase (NOX) in Experimental Liver Fibrosis: GKT137831 as a Novel Potential Therapeutic Agent. Hepatology. 2012 December; 56(6): 2316-2327. DMOVB3Y RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3493679/ DMOVB3Y DI DMOVB3Y DMOVB3Y DN GKT-137831 DMOVB3Y MI TTQRBSJ DMOVB3Y MN NADPH oxidase 4 (NOX4) DMOVB3Y MT DTT DMOVB3Y MA Modulator DMOVB3Y RN Nicotinamide Adenine Dinucleotide Phosphate Oxidase (NOX) in Experimental Liver Fibrosis: GKT137831 as a Novel Potential Therapeutic Agent. Hepatology. 2012 December; 56(6): 2316-2327. DMOVB3Y RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3493679/ DM17OZM DI DM17OZM DM17OZM DN GL-0817 DM17OZM MI TTWSKHD DM17OZM MN Melanoma-associated antigen 3 (MAGEA3) DM17OZM MT DTT DM17OZM MA Immunomodulator DM17OZM RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DM17OZM RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DMSVBND DI DMSVBND DMSVBND DN Glecaprevir DMSVBND MI DTUGYRD DMSVBND MN P-glycoprotein 1 (ABCB1) DMSVBND MT DTP DMSVBND MA Substrate DMSVBND RN Tarascon Pocket Pharmacopoeia 2018 Classic Shirt-Pocket Edition. DMSVBND RU https://books.google.com/books?id=0gBRDwAAQBAJ&pg=PP37&lpg=PP37&dq=Methylergonovine+transporter+uptake+efflex&source=bl&ots=cUTe_ppsmZ&sig=ACfU3U3E_YqrDg0CNEuj8K-7lci47HAnrg&hl=zh-CN&sa=X&ved=2ahUKEwjnj-Dk7d7iAhUsK6YKHd5DBDkQ6AEwEnoECAgQAQ#v=onepage&q&f=false DMPHCDL DI DMPHCDL DMPHCDL DN GLPG-0634 DMPHCDL MI TT6DM01 DMPHCDL MN Janus kinase 1 (JAK-1) DMPHCDL MT DTT DMPHCDL MA Modulator DMPHCDL RN Selective JAK inhibitors in development for rheumatoid arthritis. Expert Opin Investig Drugs. 2014 Aug;23(8):1067-77. DMPHCDL RU https://pubmed.ncbi.nlm.nih.gov/24818516 DMXO4T8 DI DMXO4T8 DMXO4T8 DN GLPG0974 DMXO4T8 MI TT0FYAN DMXO4T8 MN Free fatty acid receptor 2 (FFAR2) DMXO4T8 MT DTT DMXO4T8 MA Antagonist DMXO4T8 RN Discovery and optimization of an azetidine chemical series as a free fatty acid receptor 2 (FFA2) antagonist: from hit to clinic. J Med Chem. 2014 Dec 11;57(23):10044-57. DMXO4T8 RU https://pubmed.ncbi.nlm.nih.gov/25380412 DMOCRYB DI DMOCRYB DMOCRYB DN GLPG-1837 DMOCRYB MI TTRLZHP DMOCRYB MN cAMP-dependent chloride channel (CFTR) DMOCRYB MT DTT DMOCRYB MA Enhancer DMOCRYB RN Antibodies and venom peptides: new modalities for ion channels. Nat Rev Drug Discov. 2019 May;18(5):339-357. DMOCRYB RU https://pubmed.ncbi.nlm.nih.gov/30728472 DMJ85FS DI DMJ85FS DMJ85FS DN Glutathione-S-S-glutathione DMJ85FS MI DTSYQGK DMJ85FS MN Multidrug resistance-associated protein 1 (ABCC1) DMJ85FS MT DTP DMJ85FS MA Substrate DMJ85FS RN Anthracyclines modulate multidrug resistance protein (MRP) mediated organic anion transport. Biochim Biophys Acta. 1997 May 22;1326(1):12-22. DMJ85FS RU http://www.ncbi.nlm.nih.gov/pubmed/9188796 DMJ85FS DI DMJ85FS DMJ85FS DN Glutathione-S-S-glutathione DMJ85FS MI DTFI42L DMJ85FS MN Multidrug resistance-associated protein 2 (ABCC2) DMJ85FS MT DTP DMJ85FS MA Substrate DMJ85FS RN Purification of the human apical conjugate export pump MRP2 reconstitution and functional characterization as substrate-stimulated ATPase. Eur J Biochem. 1999 Oct 1;265(1):281-9. DMJ85FS RU https://doi.org/10.1046/j.1432-1327.1999.00735.x DMJ85FS DI DMJ85FS DMJ85FS DN Glutathione-S-S-glutathione DMJ85FS MI DTQ3ZHF DMJ85FS MN Multidrug resistance-associated protein 3 (ABCC3) DMJ85FS MT DTP DMJ85FS MA Substrate DMJ85FS RN MRP2 and 3 in health and disease. Cancer Lett. 2006 Mar 8;234(1):51-61. DMJ85FS RU https://doi.org/10.1016/j.canlet.2005.05.051 DML6PO5 DI DML6PO5 DML6PO5 DN GM-CSF cancer vaccine DML6PO5 MI TT6MP2Z DML6PO5 MN GMCSFR-alpha (CSF2RA) DML6PO5 MT DTT DML6PO5 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1707). DML6PO5 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1707 DMLWKZ7 DI DMLWKZ7 DMLWKZ7 DN GO-203-2c DMLWKZ7 MI TTBHFYQ DMLWKZ7 MN Mucin-1 (MUC1) DMLWKZ7 MT DTT DMLWKZ7 MA Inhibitor DMLWKZ7 RN Clinical pipeline report, company report or official report of Genus Oncology. DMLWKZ7 RU http://www.genusoncology.com/phase-1-trial-GO-203-2c.php DMKZN3A DI DMKZN3A DMKZN3A DN Golotimod DMKZN3A MI TTH8FZW DMKZN3A MN Signal transducer and activator of transcription 3 (STAT3) DMKZN3A MT DTT DMKZN3A MA Inhibitor DMKZN3A RN National Cancer Institute Drug Dictionary (drug id 617379). DMKZN3A RU http://www.cancer.gov/publications/dictionaries/cancer-drug?cdrid=617379 DMYWA0Z DI DMYWA0Z DMYWA0Z DN GORALATIDE DMYWA0Z MI TTLK6DR DMYWA0Z MN Cyclin D1 synthesis (CCND1 synthesis) DMYWA0Z MT DTT DMYWA0Z MA Modulator DMYWA0Z RN Reduction of heat-induced haemotoxicity in a hyperthermic purging protocol of murine acute myeloid leukaemic stem cells by AcSDKP. Br J Haematol. 1997 Dec;99(3):692-8. DMYWA0Z RU https://pubmed.ncbi.nlm.nih.gov/9401086 DMJWE3I DI DMJWE3I DMJWE3I DN Gossypol DMJWE3I MI TTJGNVC DMJWE3I MN Apoptosis regulator Bcl-2 (BCL-2) DMJWE3I MT DTT DMJWE3I MA Regulator DMJWE3I RN Opportunities and challenges in antiparasitic drug discovery. Nat Rev Drug Discov. 2005 Sep;4(9):727-40. DMJWE3I RU https://pubmed.ncbi.nlm.nih.gov/16138106 DM38ARE DI DM38ARE DM38ARE DN Gp100:209-217(210M) peptide vaccine DM38ARE MI TT8MK59 DM38ARE MN Melanocytes lineage-specific antigen GP100 (PMEL) DM38ARE MT DTT DM38ARE RN National Cancer Institute Drug Dictionary (drug id 476335). DM38ARE RU http://www.cancer.gov/publications/dictionaries/cancer-drug?cdrid=476335 DMOHAS2 DI DMOHAS2 DMOHAS2 DN GPC-3298306 DMOHAS2 MI TTJTSX4 DMOHAS2 MN Glypican-3 (GPC3) DMOHAS2 MT DTT DMOHAS2 RN Usefulness of a novel oncofetal antigen, glypican-3, for diagnosis and immunotherapy of hepatocellular carcinoma. Nihon Rinsho Meneki Gakkai Kaishi. 2008 Oct;31(5):383-91. DMOHAS2 RU https://pubmed.ncbi.nlm.nih.gov/18974622 DMOQ7YI DI DMOQ7YI DMOQ7YI DN GPD-1116 DMOQ7YI MI TTZ97H5 DMOQ7YI MN Phosphodiesterase 4A (PDE4A) DMOQ7YI MT DTT DMOQ7YI MA Inhibitor DMOQ7YI RN Phosphodiesterase 4 inhibitor GPD-1116 markedly attenuates the development of cigarette smoke-induced emphysema in senescence-accelerated mice P1 s... Am J Physiol Lung Cell Mol Physiol. 2008 Feb;294(2):L196-204. DMOQ7YI RU https://pubmed.ncbi.nlm.nih.gov/17993591 DMOQ7YI DI DMOQ7YI DMOQ7YI DN GPD-1116 DMOQ7YI MI TTVIAT9 DMOQ7YI MN Phosphodiesterase 4B (PDE4B) DMOQ7YI MT DTT DMOQ7YI MA Inhibitor DMOQ7YI RN Phosphodiesterase 4 inhibitor GPD-1116 markedly attenuates the development of cigarette smoke-induced emphysema in senescence-accelerated mice P1 s... Am J Physiol Lung Cell Mol Physiol. 2008 Feb;294(2):L196-204. DMOQ7YI RU https://pubmed.ncbi.nlm.nih.gov/17993591 DMOQ7YI DI DMOQ7YI DMOQ7YI DN GPD-1116 DMOQ7YI MI TTSKMI8 DMOQ7YI MN Phosphodiesterase 4D (PDE4D) DMOQ7YI MT DTT DMOQ7YI MA Inhibitor DMOQ7YI RN Phosphodiesterase 4 inhibitor GPD-1116 markedly attenuates the development of cigarette smoke-induced emphysema in senescence-accelerated mice P1 s... Am J Physiol Lung Cell Mol Physiol. 2008 Feb;294(2):L196-204. DMOQ7YI RU https://pubmed.ncbi.nlm.nih.gov/17993591 DM64ZYM DI DM64ZYM DM64ZYM DN GPI-1485 DM64ZYM MI TTMW94E DM64ZYM MN FK506-binding protein 1A (FKBP1A) DM64ZYM MT DTT DM64ZYM MA Binder DM64ZYM RN Drugs used to treat Parkinson's disease, present status and future directions. CNS Neurol Disord Drug Targets. 2008 Oct;7(4):321-42. DM64ZYM RU https://pubmed.ncbi.nlm.nih.gov/18991661 DMHNIGB DI DMHNIGB DMHNIGB DN GPX-150D DMHNIGB MI TT0IHXV DMHNIGB MN DNA topoisomerase II (TOP2) DMHNIGB MT DTT DMHNIGB MA Modulator DMHNIGB RN Company report (Gem pharmaceuticals) DMHNIGB RU http://www.gempharmaceuticals.com/targeted-therapy-approach.shtml DMMZQ7V DI DMMZQ7V DMMZQ7V DN Granotapide DMMZQ7V MI TTUS1RD DMMZQ7V MN Microsomal triglyceride transfer protein (MTTP) DMMZQ7V MT DTT DMMZQ7V MA Inhibitor DMMZQ7V RN JTT-130, a novel intestine-specific inhibitor of microsomal triglyceride transfer protein, suppresses food intake and gastric emptying with the elevation of plasma peptide YY and glucagon-like peptide-1 in a dietary fat-dependent manner. J Pharmacol Exp Ther. 2011 Mar;336(3):850-6. DMMZQ7V RU https://pubmed.ncbi.nlm.nih.gov/21139060 DMWXJSZ DI DMWXJSZ DMWXJSZ DN GRC-15300 DMWXJSZ MI TTMI6F5 DMWXJSZ MN Transient receptor potential cation channel V1 (TRPV1) DMWXJSZ MT DTT DMWXJSZ MA Antagonist DMWXJSZ RN The discovery and development of analgesics: new mechanisms, new modalities. J Clin Invest. 2010 November 1; 120(11): 3753-3759. DMWXJSZ RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2966322/ DM9QF65 DI DM9QF65 DM9QF65 DN GR-MD-02 DM9QF65 MI TTFPQV7 DM9QF65 MN Galectin-3 (LGALS3) DM9QF65 MT DTT DM9QF65 MA Inhibitor DM9QF65 RN Therapy of experimental NASH and fibrosis with galectin inhibitors. PLoS One. 2013 Dec 18;8(12):e83481. DM9QF65 RU https://pubmed.ncbi.nlm.nih.gov/24367597 DMAHOEP DI DMAHOEP DMAHOEP DN GRNVAC1 DMAHOEP MI TTUJFD0 DMAHOEP MN Telomerase reverse transcriptase (TERT) DMAHOEP MT DTT DMAHOEP RN Targeting telomerase-expressing cancer cells. J Cell Mol Med. 2011 Jul;15(7):1433-42. DMAHOEP RU https://pubmed.ncbi.nlm.nih.gov/21332640 DMHQV6R DI DMHQV6R DMHQV6R DN GS-4059 DMHQV6R MI TTGM6VW DMHQV6R MN Tyrosine-protein kinase BTK (ATK) DMHQV6R MT DTT DMHQV6R MA Inhibitor DMHQV6R RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMHQV6R RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DMBDFN7 DI DMBDFN7 DMBDFN7 DN GS-4977 DMBDFN7 MI TTOQCD8 DMBDFN7 MN Apoptosis signal-regulating kinase 1 (MAP3K5) DMBDFN7 MT DTT DMBDFN7 MA Inhibitor DMBDFN7 RN Design of a phase 2 clinical trial of an ASK1 inhibitor, GS-4997, in patients with diabetic kidney disease. Nephron. 2015;129(1):29-33. DMBDFN7 RU https://pubmed.ncbi.nlm.nih.gov/25531162 DMNABMU DI DMNABMU DMNABMU DN GS-4997 DMNABMU MI TTOQCD8 DMNABMU MN Apoptosis signal-regulating kinase 1 (MAP3K5) DMNABMU MT DTT DMNABMU MA Inhibitor DMNABMU RN Design of a phase 2 clinical trial of an ASK1 inhibitor, GS-4997, in patients with diabetic kidney disease. Nephron. 2015;129(1):29-33. DMNABMU RU https://pubmed.ncbi.nlm.nih.gov/25531162 DMDAHL6 DI DMDAHL6 DMDAHL6 DN GS-5806 DMDAHL6 MI TT57ID8 DMDAHL6 MN Respiratory syncytial virus protein F (RSV F) DMDAHL6 MT DTT DMDAHL6 MA Inhibitor DMDAHL6 RN Discovery of an oral respiratory syncytial virus (RSV) fusion inhibitor (GS-5806) and clinical proof of concept in a human RSV challenge study. J Med Chem. 2015 Feb 26;58(4):1630-43. DMDAHL6 RU https://pubmed.ncbi.nlm.nih.gov/25574686 DMSL3DX DI DMSL3DX DMSL3DX DN GS-5885 DMSL3DX MI TTCJ2X8 DMSL3DX MN Hepatitis C virus Non-structural 5A (HCV NS5A) DMSL3DX MT DTT DMSL3DX MA Modulator DMSL3DX RN Discovery of ledipasvir (GS-5885): a potent, once-daily oral NS5A inhibitor for the treatment of hepatitis C virus infection. J Med Chem. 2014 Mar 13;57(5):2033-46. DMSL3DX RU https://pubmed.ncbi.nlm.nih.gov/24320933 DMSL3DX DI DMSL3DX DMSL3DX DN GS-5885 DMSL3DX MI DTUGYRD DMSL3DX MN P-glycoprotein 1 (ABCB1) DMSL3DX MT DTP DMSL3DX MA Substrate DMSL3DX RN Tarascon Pocket Pharmacopoeia 2018 Classic Shirt-Pocket Edition. DMSL3DX RU https://books.google.com/books?id=0gBRDwAAQBAJ&pg=PP37&lpg=PP37&dq=Methylergonovine+transporter+uptake+efflex&source=bl&ots=cUTe_ppsmZ&sig=ACfU3U3E_YqrDg0CNEuj8K-7lci47HAnrg&hl=zh-CN&sa=X&ved=2ahUKEwjnj-Dk7d7iAhUsK6YKHd5DBDkQ6AEwEnoECAgQAQ#v=onepage&q&f=false DMV7ZU0 DI DMV7ZU0 DMV7ZU0 DN GS-6624 DMV7ZU0 MI TTFSUHX DMV7ZU0 MN Lysyl oxidase homolog 2 (LOXL2) DMV7ZU0 MT DTT DMV7ZU0 RN National Cancer Institute Drug Dictionary (drug id 681814). DMV7ZU0 RU http://www.cancer.gov/publications/dictionaries/cancer-drug?cdrid=681814 DMCZH5B DI DMCZH5B DMCZH5B DN GS-9256 DMCZH5B MI TT5FNQT DMCZH5B MN Human immunodeficiency virus Protease (HIV PR) DMCZH5B MT DTT DMCZH5B MA Inhibitor DMCZH5B RN Clinical pipeline report, company report or official report of Gilead (2011). DMCZH5B RU http://www.gilead.com/ DMF910Q DI DMF910Q DMF910Q DN GS-9451 DMF910Q MI TTWXB3E DMF910Q MN Hepatitis C virus NS3 helicase (HCV NS3) DMF910Q MT DTT DMF910Q MA Modulator DMF910Q RN Characterization of Resistance to the Protease Inhibitor GS-9451 in Hepatitis C Virus-Infected Patients. Antimicrob Agents Chemother. 2012 October; 56(10): 5289-5295. DMF910Q RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3457362/ DMG5C8D DI DMG5C8D DMG5C8D DN GS-9620 DMG5C8D MI DE4LYSA DMG5C8D MN Cytochrome P450 3A4 (CYP3A4) DMG5C8D MT DME DMG5C8D MA Metabolism DMG5C8D RN The oral toll-like receptor-7 agonist GS-9620 in patients with chronic hepatitis B virus infection. J Hepatol. 2015 Aug;63(2):320-8. DMG5C8D RU https://www.ncbi.nlm.nih.gov/pubmed/?term=25733157 DMG5C8D DI DMG5C8D DMG5C8D DN GS-9620 DMG5C8D MI TTRJ1K4 DMG5C8D MN Toll-like receptor 7 (TLR7) DMG5C8D MT DTT DMG5C8D MA Modulator DMG5C8D RN Pharmacokinetic and pharmacodynamic properties of GS-9620, a novel Toll-like receptor 7 agonist, demonstrate interferon-stimulated gene induction without detectable serum interferon at low oral doses. J Pharmacol Exp Ther. 2014 Jan;348(1):96-105. DMG5C8D RU https://pubmed.ncbi.nlm.nih.gov/24133297 DMYU6P5 DI DMYU6P5 DMYU6P5 DN GS-9857 DMYU6P5 MI TTWXB3E DMYU6P5 MN Hepatitis C virus NS3 helicase (HCV NS3) DMYU6P5 MT DTT DMYU6P5 MA Inhibitor DMYU6P5 RN Clinical pipeline report, company report or official report of Gilead. DMYU6P5 RU http://www.gilead.com/research/pipeline DM9Q2B6 DI DM9Q2B6 DM9Q2B6 DN GS-9876 DM9Q2B6 MI TTOU65C DM9Q2B6 MN Tyrosine-protein kinase SYK (SYK) DM9Q2B6 MT DTT DM9Q2B6 MA Inhibitor DM9Q2B6 RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DM9Q2B6 RU http://phrma-docs.phrma.org/files/dmfile/medicines-in-development-drug-list-autoimmune-diseases.pdf DMKWCTR DI DMKWCTR DMKWCTR DN GS-9973 DMKWCTR MI TTOU65C DMKWCTR MN Tyrosine-protein kinase SYK (SYK) DMKWCTR MT DTT DMKWCTR MA Modulator DMKWCTR RN An open-label phase 2 trial of entospletinib (GS-9973), a selective spleen tyrosine kinase inhibitor, in chronic lymphocytic leukemia. Blood. 2015 Apr 9;125(15):2336-43. DMKWCTR RU https://pubmed.ncbi.nlm.nih.gov/25696919 DMQGPLO DI DMQGPLO DMQGPLO DN GSK-1070806 DMQGPLO MI TTRICUF DMQGPLO MN Interleukin-18 (IL18) DMQGPLO MT DTT DMQGPLO RN Targeting the IL-1 family members in skin inflammation. Curr Opin Investig Drugs. 2010 November; 11(11): 1211-1220. DMQGPLO RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3059231/ DMDMXKQ DI DMDMXKQ DMDMXKQ DN GSK1292263 DMDMXKQ MI TT7QNVC DMDMXKQ MN Glucose-dependent insulinotropic receptor (GPR119) DMDMXKQ MT DTT DMDMXKQ MA Modulator DMDMXKQ RN Gut hormone pharmacology of a novel GPR119 agonist (GSK1292263), metformin, and sitagliptin in type 2 diabetes mellitus: results from two randomized studies.PLoS One.2014 Apr 3;9(4):e92494. DMDMXKQ RU https://www.ncbi.nlm.nih.gov/pubmed/24699248 DM1EPMF DI DM1EPMF DM1EPMF DN GSK1322322 DM1EPMF MI TTICO5G DM1EPMF MN Staphylococcus Peptide deformylase (Stap-coc def) DM1EPMF MT DTT DM1EPMF MA Modulator DM1EPMF RN Peptide deformylase: a new target in antibacterial, antimalarial and anticancer drug discovery. Curr Med Chem. 2015;22(2):214-36. DM1EPMF RU https://pubmed.ncbi.nlm.nih.gov/25174923 DMA6RBF DI DMA6RBF DMA6RBF DN GSK1325756 DMA6RBF MI TT30C9G DMA6RBF MN C-X-C chemokine receptor type 2 (CXCR2) DMA6RBF MT DTT DMA6RBF MA Modulator DMA6RBF RN Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41. DMA6RBF RU https://www.ncbi.nlm.nih.gov/pubmed/15950434 DM6HBGN DI DM6HBGN DM6HBGN DN GSK-1399686 DM6HBGN MI TTUWYEA DM6HBGN MN Bacterial 50S ribosomal RNA (Bact 50S rRNA) DM6HBGN MT DTT DM6HBGN MA Modulator DM6HBGN RN Current, new and future biological agents on the horizon for the treatment of inflammatory bowel diseases. Therap Adv Gastroenterol. 2015 March; 8(2): 66-82. DM6HBGN RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4314302/ DMZHB37 DI DMZHB37 DMZHB37 DN GSK2110183 DMZHB37 MI TTWTSCV DMZHB37 MN RAC-alpha serine/threonine-protein kinase (AKT1) DMZHB37 MT DTT DMZHB37 MA Modulator DMZHB37 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1479). DMZHB37 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1479 DMSHE70 DI DMSHE70 DMSHE70 DN GSK2141795 DMSHE70 MI TTAZ05C DMSHE70 MN RAC-gamma serine/threonine-protein kinase (AKT3) DMSHE70 MT DTT DMSHE70 MA Modulator DMSHE70 RN Inhibiting the akt pathway in cancer treatment: three leading candidates. P T. 2011 Apr;36(4):225-7. DMSHE70 RU https://pubmed.ncbi.nlm.nih.gov/21572779 DMBWPZJ DI DMBWPZJ DMBWPZJ DN GSK2245035 DMBWPZJ MI TTRJ1K4 DMBWPZJ MN Toll-like receptor 7 (TLR7) DMBWPZJ MT DTT DMBWPZJ MA Modulator DMBWPZJ RN Early clinical evaluation of the intranasal TLR7 agonist GSK2245035: Use of translational biomarkers to guide dosing and confirm target engagement. Clin Pharmacol Ther. 2015 Oct;98(4):369-80. DMBWPZJ RU https://pubmed.ncbi.nlm.nih.gov/26044169 DMG7YQL DI DMG7YQL DMG7YQL DN GSK2245840 DMG7YQL MI TTUF2HO DMG7YQL MN NAD-dependent deacetylase sirtuin-1 (SIRT1) DMG7YQL MT DTT DMG7YQL MA Modulator DMG7YQL RN Sirtuin 1 activator SRT2104 protects Huntington's disease mice. Ann Clin Transl Neurol. 2014 Dec;1(12):1047-52. DMG7YQL RU https://pubmed.ncbi.nlm.nih.gov/25574479 DMLFI7Q DI DMLFI7Q DMLFI7Q DN GSK-2251052 DMLFI7Q MI TT37GL6 DMLFI7Q MN Staphylococcus Leucyl-tRNA synthetase (Stap-coc leuS) DMLFI7Q MT DTT DMLFI7Q MA Inhibitor DMLFI7Q RN Bacterial resistance to leucyl-tRNA synthetase inhibitor GSK2251052 develops during treatment of complicated urinary tract infections. Antimicrob Agents Chemother. 2015 Jan;59(1):289-98. DMLFI7Q RU https://pubmed.ncbi.nlm.nih.gov/25348524 DMIN0SV DI DMIN0SV DMIN0SV DN GSK2269557 DMIN0SV MI TTWELHI DMIN0SV MN Stress-activated protein kinase (p38) DMIN0SV MT DTT DMIN0SV MA Inhibitor DMIN0SV RN Evaluation of WO2012032067 and WO2012055846: two selective PI3Kdelta inhibitors, which is GSK-2269557. Expert Opin Ther Pat. 2012 Aug;22(8):965-70. DMIN0SV RU https://pubmed.ncbi.nlm.nih.gov/22765651 DM4BTH8 DI DM4BTH8 DM4BTH8 DN GSK2330672 DM4BTH8 MI TTPI1M5 DM4BTH8 MN Ileal sodium/bile acid cotransporter (SLC10A2) DM4BTH8 MT DTT DM4BTH8 MA Modulator DM4BTH8 RN Discovery of a highly potent, nonabsorbable apical sodium-dependent bile acid transporter inhibitor (GSK2330672) for treatment of type 2 diabetes. J Med Chem. 2013 Jun 27;56(12):5094-114. DM4BTH8 RU https://pubmed.ncbi.nlm.nih.gov/23678871 DMB0CXT DI DMB0CXT DMB0CXT DN GSK2330811 DMB0CXT MI TTIVXSE DMB0CXT MN Oncostatin-M (OSM) DMB0CXT MT DTT DMB0CXT MA Inhibitor DMB0CXT RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMB0CXT RU http://phrma-docs.phrma.org/files/dmfile/MID_Skin_Diseases_2018_9_FINAL.pdf DMXUCG3 DI DMXUCG3 DMXUCG3 DN GSK233705 DMXUCG3 MI TTH18TF DMXUCG3 MN Muscarinic acetylcholine receptor M5 (CHRM5) DMXUCG3 MT DTT DMXUCG3 MA Antagonist DMXUCG3 RN Emerging drugs in chronic obstructive pulmonary disease. Expert Opin Emerg Drugs. 2009 Mar;14(1):181-94. DMXUCG3 RU https://pubmed.ncbi.nlm.nih.gov/19265487 DMRA3T2 DI DMRA3T2 DMRA3T2 DN GSK2339345 DMRA3T2 MI TTRK8B9 DMRA3T2 MN Sodium channel unspecific (NaC) DMRA3T2 MT DTT DMRA3T2 MA Modulator DMRA3T2 RN ClinicalTrials.gov (NCT01494636) The Safety, Tolerability, PK and PD of GSK2339345 in Healthy Subjects. U.S. National Institutes of Health. DMRA3T2 RU https://clinicaltrials.gov/ct2/show/NCT01494636 DMBJMZC DI DMBJMZC DMBJMZC DN GSK239512 DMBJMZC MI TT9JNIC DMBJMZC MN Histamine H3 receptor (H3R) DMBJMZC MT DTT DMBJMZC MA Antagonist DMBJMZC RN Clinical pipeline report, company report or official report of GlaxoSmithKline (2009). DMBJMZC RU http://www.gsk.com/investors/product_pipeline/docs/gsk-pipeline-feb09.pdf DMFAU3Z DI DMFAU3Z DMFAU3Z DN GSK249320 DMFAU3Z MI TT9XFON DMFAU3Z MN Myelin-associated glycoprotein (MAG) DMFAU3Z MT DTT DMFAU3Z RN First-time-in-human study with GSK249320, a myelin-associated glycoprotein inhibitor, in healthy volunteers. Clin Pharmacol Ther. 2013 Feb;93(2):163-9. DMFAU3Z RU https://pubmed.ncbi.nlm.nih.gov/23267856 DMMAIY2 DI DMMAIY2 DMMAIY2 DN GSK-256073 DMMAIY2 MI TTWNV8U DMMAIY2 MN Nicotinic acid receptor (HCAR2) DMMAIY2 MT DTT DMMAIY2 MA Agonist DMMAIY2 RN GSK256073, a selective agonist of G-protein coupled receptor 109A (GPR109A) reduces serum glucose in subjects with type 2 diabetes mellitus. Diabetes Obes Metab. 2013 Nov;15(11):1013-21. DMMAIY2 RU https://pubmed.ncbi.nlm.nih.gov/23701262 DMA2IXQ DI DMA2IXQ DMA2IXQ DN GSK2586184 DMA2IXQ MI TT6DM01 DMA2IXQ MN Janus kinase 1 (JAK-1) DMA2IXQ MT DTT DMA2IXQ MA Modulator DMA2IXQ RN DRESS syndrome and reversible liver function abnormalities in patients with systemic lupus erythematosus treated with the highly selective JAK-1 inhibitor GSK2586184. Lupus. 2015 May;24(6):648-9. DMA2IXQ RU https://pubmed.ncbi.nlm.nih.gov/25724932 DMU5EVR DI DMU5EVR DMU5EVR DN GSK2586881 DMU5EVR MI TTUI5H7 DMU5EVR MN Angiotensin-converting enzyme 2 (ACE2) DMU5EVR MT DTT DMU5EVR MA Modulator DMU5EVR RN New Developments in the Pharmacological Treatment of Hypertension: Dead-End or a Glimmer at the Horizon . Curr Hypertens Rep. 2015; 17(6): 42. DMU5EVR RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4412646/ DM7V96W DI DM7V96W DM7V96W DN GSK2798745 DM7V96W MI TTKP2SU DM7V96W MN Transient receptor potential cation channel V4 (TRPV4) DM7V96W MT DTT DM7V96W MA Antagonist DM7V96W RN Antibodies and venom peptides: new modalities for ion channels. Nat Rev Drug Discov. 2019 May;18(5):339-357. DM7V96W RU https://pubmed.ncbi.nlm.nih.gov/30728472 DMCIGRW DI DMCIGRW DMCIGRW DN GSK2838232 DMCIGRW MI TT5TOX7 DMCIGRW MN Human immunodeficiency virus Maturation (HIV Mat) DMCIGRW MT DTT DMCIGRW MA Modulator DMCIGRW RN Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800037762) DMCIGRW RU http://adisinsight.springer.com/drugs/800037762 DMT5YK7 DI DMT5YK7 DMT5YK7 DN GSK2890457 DMT5YK7 MI TTF5WCR DMT5YK7 MN Endogenous gut peptide (EGP) DMT5YK7 MT DTT DMT5YK7 MA Modulator DMT5YK7 RN Investigational drugs in Phase II clinical trials for the treatment of obesity: implications for future development of novel therapies. Expert Opin Investig Drugs. 2014 Aug;23(8):1055-66. DMT5YK7 RU https://pubmed.ncbi.nlm.nih.gov/25000213 DM25YLM DI DM25YLM DM25YLM DN GSK2981278 DM25YLM MI TTGV6LY DM25YLM MN Nuclear receptor ROR-gamma (RORG) DM25YLM MT DTT DM25YLM MA Agonist DM25YLM RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DM25YLM RU http://phrma-docs.phrma.org/files/dmfile/medicines-in-development-drug-list-autoimmune-diseases.pdf DM7HNFV DI DM7HNFV DM7HNFV DN GSK2982772 DM7HNFV MI TTAIQSN DM7HNFV MN Receptor-interacting protein 1 (RIPK1) DM7HNFV MT DTT DM7HNFV MA Inhibitor DM7HNFV RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DM7HNFV RU http://phrma-docs.phrma.org/files/dmfile/medicines-in-development-drug-list-autoimmune-diseases.pdf DMCDAVK DI DMCDAVK DMCDAVK DN GSK3036656 DMCDAVK MI TT46T5G DMCDAVK MN Mycobacterium Leucine-tRNA ligase (MycB leuS) DMCDAVK MT DTT DMCDAVK MA Inhibitor DMCDAVK RN Discovery of a Potent and Specific M. tuberculosis Leucyl-tRNA Synthetase Inhibitor: (S)-3-(Aminomethyl)-4-chloro-7-(2-hydroxyethoxy)benzo[c][1,2]oxaborol-1(3H)-ol (GSK656). J Med Chem. 2017 Oct 12;60(19):8011-8026. DMCDAVK RU https://pubmed.ncbi.nlm.nih.gov/28953378 DMEXKF4 DI DMEXKF4 DMEXKF4 DN GSK3196165 DMEXKF4 MI TTNYZG2 DMEXKF4 MN Granulocyte-macrophage colony-stimulating factor (CSF2) DMEXKF4 MT DTT DMEXKF4 RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMEXKF4 RU http://phrma-docs.phrma.org/files/dmfile/medicines-in-development-drug-list-autoimmune-diseases.pdf DMPBK8N DI DMPBK8N DMPBK8N DN GSK3228836 DMPBK8N MI TTSJVOI DMPBK8N MN Hepatitis B virus Large envelope protein messenger RNA (HBV S mRNA) DMPBK8N MT DTT DMPBK8N MA Inhibitor DMPBK8N RN Clinical pipeline report, company report or official report of GlaxoSmithKline. DMPBK8N RU https://www.gsk.com/en-gb/research-and-development/our-pipeline/ DMJRD7A DI DMJRD7A DMJRD7A DN GSK3326595 DMJRD7A MI TTR1D7X DMJRD7A MN Protein arginine methyltransferase 5 (PRMT5) DMJRD7A MT DTT DMJRD7A MA Inhibitor DMJRD7A RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMJRD7A RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DMO5JS3 DI DMO5JS3 DMO5JS3 DN GSK3389404 DMO5JS3 MI TTSJVOI DMO5JS3 MN Hepatitis B virus Large envelope protein messenger RNA (HBV S mRNA) DMO5JS3 MT DTT DMO5JS3 MA Inhibitor DMO5JS3 RN A Randomized, Double-Blind, Placebo-Controlled, First-Time-in-Human Study to Assess the Safety, Tolerability, and Pharmacokinetics of Single and Multiple Ascending Doses of GSK3389404 in Healthy Subjects. Clin Pharmacol Drug Dev. 2019 Aug;8(6):790-801. DMO5JS3 RU https://pubmed.ncbi.nlm.nih.gov/30861337 DMMOWT9 DI DMMOWT9 DMMOWT9 DN GSK3640254 DMMOWT9 MI TT5TOX7 DMMOWT9 MN Human immunodeficiency virus Maturation (HIV Mat) DMMOWT9 MT DTT DMMOWT9 MA Inhibitor DMMOWT9 RN Phase I evaluation of the safety, tolerability, and pharmacokinetics of GSK3640254, a next-generation HIV-1 maturation inhibitor. Pharmacol Res Perspect. 2020 Dec;8(6):e00671. DMMOWT9 RU https://pubmed.ncbi.nlm.nih.gov/33200887 DMV3TO4 DI DMV3TO4 DMV3TO4 DN GSK3810109 DMV3TO4 MI TT2ISQT DMV3TO4 MN Human immunodeficiency virus Attachment (HIV att) DMV3TO4 MT DTT DMV3TO4 MA Inhibitor DMV3TO4 RN Clinical pipeline report, company report or official report of ViiV Healthcare. DMV3TO4 RU https://viivhealthcare.com/en-us/medicines-in-development/ DMV6SNU DI DMV6SNU DMV6SNU DN GSK4069889 DMV6SNU MI TT1RWL7 DMV6SNU MN Hepatitis A virus cellular receptor 2 (TIM3) DMV6SNU MT DTT DMV6SNU MA Inhibitor DMV6SNU RN Clinical pipeline report, company report or official report of GlaxoSmithKline. DMV6SNU RU https://www.gsk.com/en-gb/research-and-development/our-pipeline/ DM3ZL2O DI DM3ZL2O DM3ZL2O DN GSK-557296 DM3ZL2O MI TTSCIUP DM3ZL2O MN Oxytocin receptor (OTR) DM3ZL2O MT DTT DM3ZL2O MA Antagonist DM3ZL2O RN Inhibition of ejaculation by the non-peptide oxytocin receptor antagonist GSK557296: a multi-level site of action. Br J Pharmacol. 2013 Aug;169(7):1477-85. DM3ZL2O RU https://pubmed.ncbi.nlm.nih.gov/23530818 DMEVARK DI DMEVARK DMEVARK DN GSK561679 DMEVARK MI TT7EFHR DMEVARK MN Corticotropin-releasing factor receptor 1 (CRHR1) DMEVARK MT DTT DMEVARK MA Antagonist DMEVARK RN Clinical pipeline report, company report or official report of GlaxoSmithKline (2009). DMEVARK RU http://www.gsk.com/investors/product_pipeline/docs/gsk-pipeline-feb09.pdf DMGU05N DI DMGU05N DMGU05N DN GSK598809 DMGU05N MI TT4C8EA DMGU05N MN Dopamine D3 receptor (D3R) DMGU05N MT DTT DMGU05N MA Antagonist DMGU05N RN Clinical pipeline report, company report or official report of GlaxoSmithKline (2009). DMGU05N RU http://www.gsk.com/investors/product_pipeline/docs/gsk-pipeline-feb09.pdf DMTW79H DI DMTW79H DMTW79H DN GSK683699 DMTW79H MI DECB0K3 DMTW79H MN Cytochrome P450 2D6 (CYP2D6) DMTW79H MT DME DMTW79H MA Metabolism DMTW79H RN Cytochrome P450 2D catalyze steroid 21-hydroxylation in the brain. Endocrinology. 2004 Feb;145(2):699-705. DMTW79H RU https://www.ncbi.nlm.nih.gov/pubmed/?term=14563706 DMTW79H DI DMTW79H DMTW79H DN GSK683699 DMTW79H MI TTPRKM0 DMTW79H MN GABA transporter GAT-1 (SLC6A1) DMTW79H MT DTT DMTW79H MA Inhibitor DMTW79H RN Novel secoergoline derivatives inhibit both GABA and glutamate uptake in rat brain homogenates: synthesis, in vitro pharmacology, and modeling. J Med Chem. 2004 Nov 4;47(23):5620-9. DMTW79H RU https://pubmed.ncbi.nlm.nih.gov/15509161 DMTW79H DI DMTW79H DMTW79H DN GSK683699 DMTW79H MI TT8RXO5 DMTW79H MN GABA transporter-3 (SLC6A11) DMTW79H MT DTT DMTW79H MA Inhibitor DMTW79H RN Epimeric cis-decahydroquinoline-5-carboxylic acids: effects on gamma-aminobutyric acid uptake and receptor binding in vitro. J Med Chem. 1981 Jul;24(7):788-94. DMTW79H RU https://pubmed.ncbi.nlm.nih.gov/6268788 DMTW79H DI DMTW79H DMTW79H DN GSK683699 DMTW79H MI TT1MPAY DMTW79H MN GABA(A) receptor alpha-1 (GABRA1) DMTW79H MT DTT DMTW79H MA Inhibitor DMTW79H RN 3-demethoxy-3-glycosylaminothiocolchicines: Synthesis of a new class of putative muscle relaxant compounds. J Med Chem. 2006 Sep 7;49(18):5571-7. DMTW79H RU https://pubmed.ncbi.nlm.nih.gov/16942030 DMTW79H DI DMTW79H DMTW79H DN GSK683699 DMTW79H MI TTBMV1G DMTW79H MN GABA(A) receptor alpha-2 (GABRA2) DMTW79H MT DTT DMTW79H MA Inhibitor DMTW79H RN New anticonvulsants: Schiff bases of gamma-aminobutyric acid and gamma-aminobutyramide. J Med Chem. 1980 Jun;23(6):702-4. DMTW79H RU https://pubmed.ncbi.nlm.nih.gov/7392039 DMTW79H DI DMTW79H DMTW79H DN GSK683699 DMTW79H MI TT37EDJ DMTW79H MN GABA(A) receptor alpha-3 (GABRA3) DMTW79H MT DTT DMTW79H MA Inhibitor DMTW79H RN New anticonvulsants: Schiff bases of gamma-aminobutyric acid and gamma-aminobutyramide. J Med Chem. 1980 Jun;23(6):702-4. DMTW79H RU https://pubmed.ncbi.nlm.nih.gov/7392039 DMTW79H DI DMTW79H DMTW79H DN GSK683699 DMTW79H MI TTNZPQ1 DMTW79H MN GABA(A) receptor alpha-5 (GABRA5) DMTW79H MT DTT DMTW79H MA Inhibitor DMTW79H RN New anticonvulsants: Schiff bases of gamma-aminobutyric acid and gamma-aminobutyramide. J Med Chem. 1980 Jun;23(6):702-4. DMTW79H RU https://pubmed.ncbi.nlm.nih.gov/7392039 DMTW79H DI DMTW79H DMTW79H DN GSK683699 DMTW79H MI TTZA1NY DMTW79H MN GABA(A) receptor beta-2 (GABRB2) DMTW79H MT DTT DMTW79H MA Inhibitor DMTW79H RN 3-demethoxy-3-glycosylaminothiocolchicines: Synthesis of a new class of putative muscle relaxant compounds. J Med Chem. 2006 Sep 7;49(18):5571-7. DMTW79H RU https://pubmed.ncbi.nlm.nih.gov/16942030 DMTW79H DI DMTW79H DMTW79H DN GSK683699 DMTW79H MI TT06RH5 DMTW79H MN GABA(A) receptor gamma-2 (GABRG2) DMTW79H MT DTT DMTW79H MA Inhibitor DMTW79H RN 3-demethoxy-3-glycosylaminothiocolchicines: Synthesis of a new class of putative muscle relaxant compounds. J Med Chem. 2006 Sep 7;49(18):5571-7. DMTW79H RU https://pubmed.ncbi.nlm.nih.gov/16942030 DMTW79H DI DMTW79H DMTW79H DN GSK683699 DMTW79H MI TTDCVZW DMTW79H MN Gamma-aminobutyric acid B receptor (GABBR) DMTW79H MT DTT DMTW79H MA Inhibitor DMTW79H RN 3-Thienyl- and 3-furylaminobutyric acids. Synthesis and binding GABAB receptor studies. J Med Chem. 1991 Aug;34(8):2557-60. DMTW79H RU https://pubmed.ncbi.nlm.nih.gov/1652022 DMTW79H DI DMTW79H DMTW79H DN GSK683699 DMTW79H MI TTNJYV2 DMTW79H MN Gamma-aminobutyric acid receptor (GAR) DMTW79H MT DTT DMTW79H MA Inhibitor DMTW79H RN 3-demethoxy-3-glycosylaminothiocolchicines: Synthesis of a new class of putative muscle relaxant compounds. J Med Chem. 2006 Sep 7;49(18):5571-7. DMTW79H RU https://pubmed.ncbi.nlm.nih.gov/16942030 DMTW79H DI DMTW79H DMTW79H DN GSK683699 DMTW79H MI TT4BT06 DMTW79H MN Integrin alpha-4 (ITGA4) DMTW79H MT DTT DMTW79H MA Binder DMTW79H RN Emerging drugs to treat Crohn's disease. Expert Opin Emerg Drugs. 2007 Mar;12(1):49-59. DMTW79H RU https://pubmed.ncbi.nlm.nih.gov/17355213 DMTW79H DI DMTW79H DMTW79H DN GSK683699 DMTW79H MI DT8Z563 DMTW79H MN Sodium- and chloride-dependent GABA transporter 1 (SLC6A1) DMTW79H MT DTP DMTW79H MA Substrate DMTW79H RN Mutations in the GABA Transporter SLC6A1 Cause Epilepsy with Myoclonic-Atonic Seizures. Am J Hum Genet. 2015 May 7;96(5):808-15. DMTW79H RU http://www.ncbi.nlm.nih.gov/pubmed/25865495 DMTW79H DI DMTW79H DMTW79H DN GSK683699 DMTW79H MI DTXQYLR DMTW79H MN Vesicular inhibitory amino acid transporter (SLC32A1) DMTW79H MT DTP DMTW79H MA Substrate DMTW79H RN Wakefulness Is Governed by GABA and Histamine Cotransmission. Neuron. 2015 Jul 1;87(1):164-78. DMTW79H RU http://www.ncbi.nlm.nih.gov/pubmed/26094607 DMPLKAH DI DMPLKAH DMPLKAH DN GSK-706769 DMPLKAH MI TT2CEJG DMPLKAH MN C-C chemokine receptor type 5 (CCR5) DMPLKAH MT DTT DMPLKAH MA Antagonist DMPLKAH RN Tapping into combination pills for HIV. Nat Rev Drug Discov. 2009 Jun;8(6):439-40. DMPLKAH RU https://pubmed.ncbi.nlm.nih.gov/19483700 DMIEXUM DI DMIEXUM DMIEXUM DN GSK768974 DMIEXUM MI TTEPJL5 DMIEXUM MN Parathyroid hormone receptor (PTH2R) DMIEXUM MT DTT DMIEXUM MA Agonist DMIEXUM RN Comparison of bone formation responses to parathyroid hormone(1-34), (1-31), and (2-34) in mice. Bone. 2000 Oct;27(4):471-8. DMIEXUM RU https://pubmed.ncbi.nlm.nih.gov/11033441 DMX27Q1 DI DMX27Q1 DMX27Q1 DN GSK933776A DMX27Q1 MI TTE4KHA DMX27Q1 MN Amyloid beta A4 protein (APP) DMX27Q1 MT DTT DMX27Q1 MA Modulator DMX27Q1 RN Profile of gantenerumab and its potential in the treatment of Alzheimer's disease. Correction in: Drug Des Devel Ther. 2014; 8: 569. DMX27Q1 RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3832388/ DM6DKF9 DI DM6DKF9 DM6DKF9 DN GSK961081 DM6DKF9 MI TT2CJVK DM6DKF9 MN Adrenergic receptor beta-2 (ADRB2) DM6DKF9 MT DTT DM6DKF9 MA Modulator DM6DKF9 RN Pharmacologic characterization of GSK-961081 (TD-5959), a first-in-class inhaled bifunctional bronchodilator possessing muscarinic receptor antagonist and 2-adrenoceptor agonist properties.J Pharmacol Exp Ther.2014 Oct;351(1):190-9. DM6DKF9 RU https://www.ncbi.nlm.nih.gov/pubmed/25100753 DM8N3OQ DI DM8N3OQ DM8N3OQ DN GT-AADC DM8N3OQ MI TTN451K DM8N3OQ MN Aromatic-L-amino-acid decarboxylase (DDC) DM8N3OQ MT DTT DM8N3OQ MA Replacement DM8N3OQ RN Clinical pipeline report, company report or official report of PTC Therapeutics. DM8N3OQ RU https://www.ptcbio.com/our-pipeline/areas-of-interest/additional-areas/ DMN6IDO DI DMN6IDO DMN6IDO DN GTP-010 DMN6IDO MI TTVIMDE DMN6IDO MN Glucagon-like peptide 1 receptor (GLP1R) DMN6IDO MT DTT DMN6IDO MA Agonist DMN6IDO RN Emerging drugs for irritable bowel syndrome. Expert Opin Emerg Drugs. 2006 May;11(2):293-313. DMN6IDO RU https://pubmed.ncbi.nlm.nih.gov/16634703 DM03NQS DI DM03NQS DM03NQS DN GTP-200 DM03NQS MI TTWDC17 DM03NQS MN Growth hormone secretagogue receptor 1 (GHSR) DM03NQS MT DTT DM03NQS MA Agonist DM03NQS RN Orphan GPCR research. Br J Pharmacol. 2008 March; 153(Suppl 1): S339-S346. DM03NQS RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2268047/ DMEN5KA DI DMEN5KA DMEN5KA DN GTS-21 DMEN5KA MI DEJGDUW DMEN5KA MN Cytochrome P450 1A2 (CYP1A2) DMEN5KA MT DME DMEN5KA MA Metabolism DMEN5KA RN Metabolism and disposition of GTS-21, a novel drug for Alzheimer's disease. Xenobiotica. 1999 Jul;29(7):747-62. DMEN5KA RU https://www.ncbi.nlm.nih.gov/pubmed/?term=10456692 DMEN5KA DI DMEN5KA DMEN5KA DN GTS-21 DMEN5KA MI TTLA931 DMEN5KA MN Neuronal acetylcholine receptor alpha-7 (CHRNA7) DMEN5KA MT DTT DMEN5KA MA Agonist DMEN5KA RN The brain alpha7 nicotinic receptor may be an important therapeutic target for the treatment of Alzheimer's disease: studies with DMXBA (GTS-21). Behav Brain Res. 2000 Aug;113(1-2):169-81. DMEN5KA RU https://pubmed.ncbi.nlm.nih.gov/10942043 DMDWYZS DI DMDWYZS DMDWYZS DN GTx-758 DMDWYZS MI TTZAYWL DMDWYZS MN Estrogen receptor (ESR) DMDWYZS MT DTT DMDWYZS MA Modulator DMDWYZS RN Selective estrogen receptor alpha agonist GTx-758 decreases testosterone with reduced side effects of androgen deprivation therapy in men with advanced prostate cancer. Eur Urol. 2015 Feb;67(2):334-41. DMDWYZS RU https://pubmed.ncbi.nlm.nih.gov/24968970 DMY53PL DI DMY53PL DMY53PL DN GW 597599 DMY53PL MI TTZPO1L DMY53PL MN Substance-P receptor (TACR1) DMY53PL MT DTT DMY53PL MA Antagonist DMY53PL RN Application of LC-NMR to the identification of bulk drug impurities in NK1 antagonist GW597599 (vestipitant). Magn Reson Chem. 2010 Jul;48(7):523-30. DMY53PL RU https://pubmed.ncbi.nlm.nih.gov/20535779 DMZMCB1 DI DMZMCB1 DMZMCB1 DN GW274150 DMZMCB1 MI TTF10I9 DMZMCB1 MN Nitric-oxide synthase inducible (NOS2) DMZMCB1 MT DTT DMZMCB1 MA Modulator DMZMCB1 RN GW274150, a potent and highly selective inhibitor of iNOS, reduces experimental renal ischemia/reperfusion injury. Kidney Int. 2003 Mar;63(3):853-65. DMZMCB1 RU https://www.ncbi.nlm.nih.gov/pubmed/12631066 DMY3KSU DI DMY3KSU DMY3KSU DN GW-42004 DMY3KSU MI TT6OEDT DMY3KSU MN Cannabinoid receptor 1 (CB1) DMY3KSU MT DTT DMY3KSU MA Modulator DMY3KSU RN Company report (Gwpharm) DMY3KSU RU http://www.gwpharm.com/GW%20Pharmaceuticals%20Provides%20Update%20on%20Cannabinoid%20Pipeline.aspx DMY3KSU DI DMY3KSU DMY3KSU DN GW-42004 DMY3KSU MI TTMSFAW DMY3KSU MN Cannabinoid receptor 2 (CB2) DMY3KSU MT DTT DMY3KSU MA Modulator DMY3KSU RN Company report (Gwpharm) DMY3KSU RU http://www.gwpharm.com/GW%20Pharmaceuticals%20Provides%20Update%20on%20Cannabinoid%20Pipeline.aspx DMBX9C0 DI DMBX9C0 DMBX9C0 DN GW-427353 DMBX9C0 MI TTMXGCW DMBX9C0 MN Adrenergic receptor beta-3 (ADRB3) DMBX9C0 MT DTT DMBX9C0 MA Agonist DMBX9C0 RN Emerging drugs for obesity: linking novel biological mechanisms to pharmaceutical pipelines. Expert Opin Emerg Drugs. 2005 Aug;10(3):643-60. DMBX9C0 RU https://pubmed.ncbi.nlm.nih.gov/16083333 DMH0C8J DI DMH0C8J DMH0C8J DN GW-813893 DMH0C8J MI TTCIHJA DMH0C8J MN Coagulation factor Xa (F10) DMH0C8J MT DTT DMH0C8J MA Inhibitor DMH0C8J RN Semuloparin for the prevention of venous thromboembolic events in cancer patients. Drugs Today (Barc). 2012 Jul;48(7):451-7. DMH0C8J RU https://pubmed.ncbi.nlm.nih.gov/22844656 DM489FT DI DM489FT DM489FT DN GW-870086-X DM489FT MI TTYRL6O DM489FT MN Glucocorticoid receptor (NR3C1) DM489FT MT DTT DM489FT MA Agonist DM489FT RN Unique response profile of trabecular meshwork cells to the novel selective glucocorticoid receptor agonist, GW870086X. Invest Ophthalmol Vis Sci. 2013 Mar 1;54(3):2100-7. DM489FT RU https://pubmed.ncbi.nlm.nih.gov/23462748 DMQEC9P DI DMQEC9P DMQEC9P DN GW-870086-X DMQEC9P MI TTYRL6O DMQEC9P MN Glucocorticoid receptor (NR3C1) DMQEC9P MT DTT DMQEC9P MA Agonist DMQEC9P RN Unique response profile of trabecular meshwork cells to the novel selective glucocorticoid receptor agonist, GW870086X. Invest Ophthalmol Vis Sci. 2013 Mar 1;54(3):2100-7. DMQEC9P RU https://pubmed.ncbi.nlm.nih.gov/23462748 DM8XH3S DI DM8XH3S DM8XH3S DN H-1152 DM8XH3S MI TTZN7RP DM8XH3S MN Rho-associated protein kinase 1 (ROCK1) DM8XH3S MT DTT DM8XH3S MA Inhibitor DM8XH3S RN Emerging treatments for pulmonary arterial hypertension. Expert Opin Emerg Drugs. 2006 Nov;11(4):609-19. DM8XH3S RU https://pubmed.ncbi.nlm.nih.gov/17064221 DMO4I61 DI DMO4I61 DMO4I61 DN H5N1 influenza vaccine DMO4I61 MI TT3J5ZI DMO4I61 MN Cell mediated immunity response (CMIR) DMO4I61 MT DTT DMO4I61 RN Anti-influenza agents from Traditional Chinese Medicine. Nat Prod Rep. 2010 Jan;27(12):1758-80. DMO4I61 RU https://pubmed.ncbi.nlm.nih.gov/20941447 DM74ZKN DI DM74ZKN DM74ZKN DN HBI-3000 DM74ZKN MI TT5HONZ DM74ZKN MN Calcium channel unspecific (CaC) DM74ZKN MT DTT DM74ZKN MA Blocker DM74ZKN RN Electrophysiological properties of HBI-3000: a new antiarrhythmic agent with multiple-channel blocking properties in human ventricular myocytes. J Cardiovasc Pharmacol. 2011 Jan;57(1):79-85. DM74ZKN RU https://pubmed.ncbi.nlm.nih.gov/20980921 DM74ZKN DI DM74ZKN DM74ZKN DN HBI-3000 DM74ZKN MI TT1VOHK DM74ZKN MN Potassium channel unspecific (KC) DM74ZKN MT DTT DM74ZKN MA Blocker DM74ZKN RN Electrophysiological properties of HBI-3000: a new antiarrhythmic agent with multiple-channel blocking properties in human ventricular myocytes. J Cardiovasc Pharmacol. 2011 Jan;57(1):79-85. DM74ZKN RU https://pubmed.ncbi.nlm.nih.gov/20980921 DM74ZKN DI DM74ZKN DM74ZKN DN HBI-3000 DM74ZKN MI TTRK8B9 DM74ZKN MN Sodium channel unspecific (NaC) DM74ZKN MT DTT DM74ZKN MA Inhibitor DM74ZKN RN Antibodies and venom peptides: new modalities for ion channels. Nat Rev Drug Discov. 2019 May;18(5):339-357. DM74ZKN RU https://pubmed.ncbi.nlm.nih.gov/30728472 DMSMCXN DI DMSMCXN DMSMCXN DN HBV vaccine DMSMCXN MI TT3J5ZI DMSMCXN MN Cell mediated immunity response (CMIR) DMSMCXN MT DTT DMSMCXN RN ClinicalTrials.gov (NCT00508833) Safety and Efficacy of SmithKline Beecham (GlaxoSmithKline [GSK]) Biologicals' Candidate Adjuvanted Vaccines (287615). U.S. National Institutes of Health. DMSMCXN RU https://clinicaltrials.gov/ct2/show/NCT00508833 DMX8C6J DI DMX8C6J DMX8C6J DN HCB1019 DMX8C6J MI TT4F7SL DMX8C6J MN Gap junction alpha-1 protein (GJA1) DMX8C6J MT DTT DMX8C6J MA Inhibitor DMX8C6J RN Clinical pipeline report, company report or official report of OcuNexus Therapeutics. DMX8C6J RU https://ocunexus.com/ophthalmic DMRQGMZ DI DMRQGMZ DMRQGMZ DN HD-003 DMRQGMZ MI TT20DOQ DMRQGMZ MN Hydroxy radical elimination (HYRE) DMRQGMZ MT DTT DMRQGMZ MA Modulator DMRQGMZ RN Creatinine and HMH (5-hydroxy-1-methylhydantoin, NZ-419) as intrinsic hydroxyl radical scavengers. Drug Discov Ther. 2011 Aug;5(4):162-75. DMRQGMZ RU https://pubmed.ncbi.nlm.nih.gov/22466296 DMAX632 DI DMAX632 DMAX632 DN HDV-interferon DMAX632 MI TTV2CN0 DMAX632 MN Interferon receptor (IFNR) DMAX632 MT DTT DMAX632 MA Modulator DMAX632 RN Interferon in HDV infection. Antiviral Res. 1994 Jul;24(2-3):165-74. DMAX632 RU https://pubmed.ncbi.nlm.nih.gov/7979316 DMV50R1 DI DMV50R1 DMV50R1 DN HE3235 DMV50R1 MI DE4LYSA DMV50R1 MN Cytochrome P450 3A4 (CYP3A4) DMV50R1 MT DME DMV50R1 MA Metabolism DMV50R1 RN 17alpha-alkynyl 3alpha, 17beta-androstanediol non-clinical and clinical pharmacology, pharmacokinetics and metabolism. Invest New Drugs. 2012 Feb;30(1):59-78. DMV50R1 RU http://www.ncbi.nlm.nih.gov/pubmed/20814732 DMV50R1 DI DMV50R1 DMV50R1 DN HE3235 DMV50R1 MI DEGTFWK DMV50R1 MN Mephenytoin 4-hydroxylase (CYP2C19) DMV50R1 MT DME DMV50R1 MA Metabolism DMV50R1 RN 17alpha-alkynyl 3alpha, 17beta-androstanediol non-clinical and clinical pharmacology, pharmacokinetics and metabolism. Invest New Drugs. 2012 Feb;30(1):59-78. DMV50R1 RU http://www.ncbi.nlm.nih.gov/pubmed/20814732 DMV50R1 DI DMV50R1 DMV50R1 DN HE3235 DMV50R1 MI TTYA7V2 DMV50R1 MN Prostate cance cell (PCC) DMV50R1 MT DTT DMV50R1 MA Inhibitor DMV50R1 RN 17alpha-alkynyl 3alpha, 17beta-androstanediol non-clinical and clinical pharmacology, pharmacokinetics and metabolism. Invest New Drugs. 2012 Feb;30(1):59-78. DMV50R1 RU https://pubmed.ncbi.nlm.nih.gov/20814732 DM9OZU5 DI DM9OZU5 DM9OZU5 DN Heat shock protein vaccine DM9OZU5 MI TTG91S4 DM9OZU5 MN Heat shock protein (HSP) DM9OZU5 MT DTT DM9OZU5 RN Heat shock proteins (HSPs) based anti-cancer vaccines. Curr Mol Med. 2012 Nov 1;12(9):1183-97. DM9OZU5 RU https://pubmed.ncbi.nlm.nih.gov/22804241 DM8QGPE DI DM8QGPE DM8QGPE DN HepaStem DM8QGPE MI TTGSVH2 DM8QGPE MN Phenylalanine hydroxylase (PAH) DM8QGPE MT DTT DM8QGPE MA Modulator DM8QGPE RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1240). DM8QGPE RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1240 DMX6B95 DI DMX6B95 DMX6B95 DN HER1-VSSP vaccine DMX6B95 MI TTGKNB4 DMX6B95 MN Epidermal growth factor receptor (EGFR) DMX6B95 MT DTT DMX6B95 RN Active antimetastatic immunotherapy in Lewis lung carcinoma with self EGFR extracellular domain protein in VSSP adjuvant. Int J Cancer. 2006 Nov 1;119(9):2190-9. DMX6B95 RU https://pubmed.ncbi.nlm.nih.gov/16841332 DM8TOS0 DI DM8TOS0 DM8TOS0 DN HER-2 Protein AutoVac DM8TOS0 MI TT6EO5L DM8TOS0 MN Erbb2 tyrosine kinase receptor (HER2) DM8TOS0 MT DTT DM8TOS0 MA Inhibitor DM8TOS0 RN Treatment of HER2-positive breast cancer: current status and future perspectives. Nat Rev Clin Oncol. 2011 Nov 29;9(1):16-32. DM8TOS0 RU https://pubmed.ncbi.nlm.nih.gov/22124364 DMISETH DI DMISETH DMISETH DN HER2/neu peptide vaccine DMISETH MI TT6EO5L DMISETH MN Erbb2 tyrosine kinase receptor (HER2) DMISETH MT DTT DMISETH RN N-terminally LRMK-linked HER-2 peptides, AE-37 [p776(774-788)] and AE-47 [Ava-F7(776-788)], aid differentiation of E75-TCR+CD8+ cells to perforin-positive cells. Anticancer Res. 2009 Jul;29(7):2427-35. DMISETH RU https://pubmed.ncbi.nlm.nih.gov/19596910 DMQTREC DI DMQTREC DMQTREC DN Her2-targeted autologous T-cell therapy DMQTREC MI TT6EO5L DMQTREC MN Erbb2 tyrosine kinase receptor (HER2) DMQTREC MT DTT DMQTREC MA Inhibitor DMQTREC RN A new hope in immunotherapy for malignant gliomas: adoptive T cell transfer therapy. J Immunol Res. 2014;2014:326545. DMQTREC RU https://pubmed.ncbi.nlm.nih.gov/25009822 DMI4C90 DI DMI4C90 DMI4C90 DN HF-0220 DMI4C90 MI TTCYE56 DMI4C90 MN Glutathione-dependent PGD synthase (HPGDS) DMI4C90 MT DTT DMI4C90 MA Stimulator DMI4C90 RN US patent application no. 2009,0062,529, Multi-cyclic compounds. DMI4C90 RU http://www.google.st/patents/US20090062529 DMDZE3B DI DMDZE3B DMDZE3B DN HGT-1111 DMDZE3B MI TTYQANR DMDZE3B MN Cerebroside-sulfatase (ARSA) DMDZE3B MT DTT DMDZE3B MA Modulator DMDZE3B RN ClinicalTrials.gov (NCT00681811) Open-Label Extension Study of Recombinant Human Arylsulfatase A (HGT-1111) in Late Infantile MLD. U.S. National Institutes of Health. DMDZE3B RU https://clinicaltrials.gov/ct2/show/NCT00681811 DMHZ4JI DI DMHZ4JI DMHZ4JI DN HGT-1410 DMHZ4JI MI TTPJ2SH DMHZ4JI MN N-sulphoglucosamine sulphohydrolase (SGSH) DMHZ4JI MT DTT DMHZ4JI MA Modulator DMHZ4JI RN ClinicalTrials.gov (NCT01155778) Safety, Tolerability, Ascending Dose and Dose Frequency Study of rhHNS Via an IDDD in MPS IIIA Patients. U.S. National Institutes of Health. DMHZ4JI RU https://clinicaltrials.gov/ct2/show/NCT01155778 DM0LA6E DI DM0LA6E DM0LA6E DN HGTV43 DM0LA6E MI TTRP4JT DM0LA6E MN Human immunodeficiency virus Rev messenger RNA (HIV rev mRNA) DM0LA6E MT DTT DM0LA6E RN Design and development of antisense drugs. Expert Opin. Drug Discov. 2008 3(10):1189-1207. DM0LA6E RU http://www.informahealthcare.com/doi/abs/10.1517/17460441.3.10.1177 DM0LA6E DI DM0LA6E DM0LA6E DN HGTV43 DM0LA6E MI TTFP96H DM0LA6E MN Human immunodeficiency virus Tat messenger RNA (HIV tat mRNA) DM0LA6E MT DTT DM0LA6E RN Design and development of antisense drugs. Expert Opin. Drug Discov. 2008 3(10):1189-1207. DM0LA6E RU http://www.informahealthcare.com/doi/abs/10.1517/17460441.3.10.1177 DM0LA6E DI DM0LA6E DM0LA6E DN HGTV43 DM0LA6E MI TT6S84O DM0LA6E MN Human immunodeficiency virus Trans-activation response element (HIV TAR RNA element) DM0LA6E MT DTT DM0LA6E RN Design and development of antisense drugs. Expert Opin. Drug Discov. 2008 3(10):1189-1207. DM0LA6E RU http://www.informahealthcare.com/doi/abs/10.1517/17460441.3.10.1177 DMO10JI DI DMO10JI DMO10JI DN HibTITER DMO10JI MI TTC6JZQ DMO10JI MN Haemophilus influenzae CRM197 (Hae-influ CRM197) DMO10JI MT DTT DMO10JI RN Immunogenicity and safety of Haemophilus influenzae type b conjugate vaccine (HibTITER) and a combination vaccine of diphtheria, tetanus, pertussis and HibTITER (TETRAMUNE) in two-month-old infants. J Microbiol Immunol Infect. 1998 Sep;31(3):180-6. DMO10JI RU https://pubmed.ncbi.nlm.nih.gov/10496155 DMLQDBH DI DMLQDBH DMLQDBH DN HM-5016504 DMLQDBH MI TTNDSF4 DMLQDBH MN Proto-oncogene c-Met (MET) DMLQDBH MT DTT DMLQDBH MA Inhibitor DMLQDBH RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1815). DMLQDBH RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1815 DMZ3BER DI DMZ3BER DMZ3BER DN HM-78136B DMZ3BER MI TTGKNB4 DMZ3BER MN Epidermal growth factor receptor (EGFR) DMZ3BER MT DTT DMZ3BER MA Inhibitor DMZ3BER RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMZ3BER RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DMZ3BER DI DMZ3BER DMZ3BER DN HM-78136B DMZ3BER MI TT6EO5L DMZ3BER MN Erbb2 tyrosine kinase receptor (HER2) DMZ3BER MT DTT DMZ3BER MA Inhibitor DMZ3BER RN Antitumor activity of HM781-36B, a highly effective pan-HER inhibitor in erlotinib-resistant NSCLC and other EGFR-dependent cancer models. Int J Cancer. 2012 May 15;130(10):2445-54. DMZ3BER RU https://pubmed.ncbi.nlm.nih.gov/21732342 DMMQZ3I DI DMMQZ3I DMMQZ3I DN HMR59 DMMQZ3I MI TTBGTEJ DMMQZ3I MN Membrane inhibitor of reactive lysis (CD59) DMMQZ3I MT DTT DMMQZ3I MA Replacement DMMQZ3I RN Clinical pipeline report, company report or official report of Hemera Biosciences. DMMQZ3I RU https://www.hemerabiosciences.com/hmr59/ DMA6HQJ DI DMA6HQJ DMA6HQJ DN HO/03/03 DMA6HQJ MI TTYVX59 DMA6HQJ MN Protein kinase C (PRKC) DMA6HQJ MT DTT DMA6HQJ MA Modulator DMA6HQJ RN WO patent application no. 2014,0853,81, Pharmaceutical combinations. DMA6HQJ RU http://worldwide.espacenet.com/publicationDetails/biblio?DB=worldwide.espacenet.com&II=0&ND=3&adjacent=true&locale=en_EP&FT=D&date=20140605&CC=WO&NR=2014085381A1&KC=A1 DMNOMV2 DI DMNOMV2 DMNOMV2 DN HP-184 DMNOMV2 MI TTQ6VDM DMNOMV2 MN Voltage-gated potassium channel Kv11.1 (KCNH2) DMNOMV2 MT DTT DMNOMV2 MA Blocker DMNOMV2 RN Emerging drugs for spinal cord injury. Expert Opin Emerg Drugs. 2008 Mar;13(1):63-80. DMNOMV2 RU https://pubmed.ncbi.nlm.nih.gov/18321149 DMNOMV2 DI DMNOMV2 DMNOMV2 DN HP-184 DMNOMV2 MI TTN9VTF DMNOMV2 MN Voltage-gated sodium channel alpha Nav1.9 (SCN11A) DMNOMV2 MT DTT DMNOMV2 MA Blocker DMNOMV2 RN Emerging drugs for spinal cord injury. Expert Opin Emerg Drugs. 2008 Mar;13(1):63-80. DMNOMV2 RU https://pubmed.ncbi.nlm.nih.gov/18321149 DMNZ35F DI DMNZ35F DMNZ35F DN HP-228 DMNZ35F MI TTF10I9 DMNZ35F MN Nitric-oxide synthase inducible (NOS2) DMNZ35F MT DTT DMNZ35F MA Modulator DMNZ35F RN HP-228, a novel synthetic peptide, inhibits the induction of nitric oxide synthase in vivo but not in vitro. J Pharmacol Exp Ther. 1995 Nov;275(2):584-91. DMNZ35F RU https://pubmed.ncbi.nlm.nih.gov/7473142 DM3WSL2 DI DM3WSL2 DM3WSL2 DN HPH-116 DM3WSL2 MI TT8Z1OP DM3WSL2 MN Human immunodeficiency virus Nucleocapsid p7 (HIV p7) DM3WSL2 MT DTT DM3WSL2 MA Modulator DM3WSL2 RN Clinical pipeline report, company report or official report of H-Phar. DM3WSL2 RU http://www.h-phar.com/Projects_Projet_1.php DM25PQB DI DM25PQB DM25PQB DN HPPH DM25PQB MI DTI7UX6 DM25PQB MN Breast cancer resistance protein (ABCG2) DM25PQB MT DTP DM25PQB MA Substrate DM25PQB RN Substrate affinity of photosensitizers derived from chlorophyll-a: the ABCG2 transporter affects the phototoxic response of side population stem cell-like cancer cells to photodynamic therapy. Mol Pharm. 2010 Oct 4;7(5):1789-804. DM25PQB RU https://doi.org/10.1021/mp100154j DM7QUN0 DI DM7QUN0 DM7QUN0 DN HQK-1001 DM7QUN0 MI TTQO71U DM7QUN0 MN Hemoglobin (HB) DM7QUN0 MT DTT DM7QUN0 MA Inducer DM7QUN0 RN A phase 2 study of HQK-1001, an oral fetal haemoglobin inducer, in beta-thalassaemia intermedia. Br J Haematol. 2014 Feb;164(3):456-8. DM7QUN0 RU https://pubmed.ncbi.nlm.nih.gov/24224649 DM3WX0K DI DM3WX0K DM3WX0K DN HQK-1004 DM3WX0K MI TTP3QRF DM3WX0K MN Thymidine kinase 1 (TK1) DM3WX0K MT DTT DM3WX0K MA Modulator DM3WX0K RN Induction of the Epstein-Barr virus thymidine kinase gene with concomitant nucleoside antivirals as a therapeutic strategy for Epstein-Barr virus-associated malignancies. Curr Opin Oncol. 2001 Sep;13(5):360-7. DM3WX0K RU https://pubmed.ncbi.nlm.nih.gov/11555713 DMQ30X2 DI DMQ30X2 DMQ30X2 DN HQP1351 DMQ30X2 MI TTS7G69 DMQ30X2 MN Fusion protein Bcr-Abl (Bcr-Abl) DMQ30X2 MT DTT DMQ30X2 MA Inhibitor DMQ30X2 RN Preclinical development of HQP1351, a multikinase inhibitor targeting a broad spectrum of mutant KIT kinases, for the treatment of imatinib-resistant gastrointestinal stromal tumors. Cell Biosci. 2019 Oct 26;9:88. DMQ30X2 RU https://pubmed.ncbi.nlm.nih.gov/31673329 DML4RCG DI DML4RCG DML4RCG DN HS-110 DML4RCG MI TTFZDNP DML4RCG MN Activation B7-1 antigen (CD80) DML4RCG MT DTT DML4RCG RN Clinical pipeline report, company report or official report of Heat Biologics. DML4RCG RU http://www.heatbio.com/product-pipeline/hs-110 DML4RCG DI DML4RCG DML4RCG DN HS-110 DML4RCG MI TTFPKXQ DML4RCG MN Endoplasmin (HSP90B1) DML4RCG MT DTT DML4RCG RN Clinical pipeline report, company report or official report of Heat Biologics. DML4RCG RU http://www.heatbio.com/product-pipeline/hs-110 DM2WP8F DI DM2WP8F DM2WP8F DN HT-0712 DM2WP8F MI TTZ97H5 DM2WP8F MN Phosphodiesterase 4A (PDE4A) DM2WP8F MT DTT DM2WP8F MA Inhibitor DM2WP8F RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1300). DM2WP8F RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1300 DM2WP8F DI DM2WP8F DM2WP8F DN HT-0712 DM2WP8F MI TTVIAT9 DM2WP8F MN Phosphodiesterase 4B (PDE4B) DM2WP8F MT DTT DM2WP8F MA Inhibitor DM2WP8F RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1301). DM2WP8F RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1301 DM2WP8F DI DM2WP8F DM2WP8F DN HT-0712 DM2WP8F MI TTSKMI8 DM2WP8F MN Phosphodiesterase 4D (PDE4D) DM2WP8F MT DTT DM2WP8F MA Inhibitor DM2WP8F RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1303). DM2WP8F RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1303 DM2QIN1 DI DM2QIN1 DM2QIN1 DN HT-100 DM2QIN1 MI TTXYCDZ DM2QIN1 MN Bifunctional aminoacyl-tRNA synthetase (EPRS) DM2QIN1 MT DTT DM2QIN1 MA Modulator DM2QIN1 RN Halofuginone and other febrifugine derivatives inhibit prolyl-tRNA synthetase. Nat Chem Biol. 2012 Feb 12;8(3):311-7. DM2QIN1 RU https://pubmed.ncbi.nlm.nih.gov/22327401 DMURXMJ DI DMURXMJ DMURXMJ DN HTI-101 DMURXMJ MI TT3C1VN DMURXMJ MN Enzyme unspecific (Enz) DMURXMJ MT DTT DMURXMJ MA Antagonist DMURXMJ RN Halozyme Therapeutics Announces New Studies From HTI-101 Presented at Proteoglycan Research Conference. Halozyme Therapeutics. JULY 12, 2006. DMURXMJ RU http://www.prnewswire.com/news-releases/halozyme-therapeutics-announces-new-studies-from-hti-101-presented-at-proteoglycan-research-conference-56000982.html DM9MKQ5 DI DM9MKQ5 DM9MKQ5 DN Hu3F8 mAb DM9MKQ5 MI TT80ARU DM9MKQ5 MN Ganglioside GD2 (GD2) DM9MKQ5 MT DTT DM9MKQ5 RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DM9MKQ5 RU http://phrma-docs.phrma.org/files/dmfile/MID_Immuno-Oncology-2017_Drug-List1.pdf DMKQ3MC DI DMKQ3MC DMKQ3MC DN Human interferon alpha oral DMKQ3MC MI TT95SOA DMKQ3MC MN Interferon alpha (IFNA) DMKQ3MC MT DTT DMKQ3MC MA Modulator DMKQ3MC RN Low-dose oral natural human interferon-alpha in 29 patients with HIV-1 infection: a double-blind, randomized, placebo-controlled trial. AIDS. 1992 Jun;6(6):563-9. DMKQ3MC RU https://pubmed.ncbi.nlm.nih.gov/1388878 DM0NJWG DI DM0NJWG DM0NJWG DN Human interleukin-2 DM0NJWG MI TTF89GD DM0NJWG MN Interleukin-2 (IL2) DM0NJWG MT DTT DM0NJWG MA Modulator DM0NJWG RN Clinical pipeline report, company report or official report of Immunservice. DM0NJWG RU http://www.immunservice.com/index.php?page=regulatory DMOPWSX DI DMOPWSX DMOPWSX DN Ibrolipim DMOPWSX MI TTOF3WZ DMOPWSX MN Lipoprotein lipase (LPL) DMOPWSX MT DTT DMOPWSX MA Modulator DMOPWSX RN NO-1886 (ibrolipim), a lipoprotein lipase activator, increases the expression of uncoupling protein 3 in skeletal muscle and suppresses fat accumulation in high-fat diet-induced obesity in rats. Metabolism. 2005 Dec;54(12):1587-92. DMOPWSX RU https://pubmed.ncbi.nlm.nih.gov/16311090 DM37CX4 DI DM37CX4 DM37CX4 DN IC14 DM37CX4 MI TTCLGZ8 DM37CX4 MN HUAMN monocyte differentiation antigen CD14 (CD14) DM37CX4 MT DTT DM37CX4 MA Inhibitor DM37CX4 RN IC14 (Anti-CD14) Treatment in Patients With SARS-CoV-2 (COVID-19) DM37CX4 RU https://clinicaltrials.gov/ct2/show/NCT04391309 DMUFCQG DI DMUFCQG DMUFCQG DN IC14 DMUFCQG MI TT6I7DC DMUFCQG MN Monocyte differentiation antigen CD14 (CD14) DMUFCQG MT DTT DMUFCQG RN IC14, a CD14 specific monoclonal antibody, is a potential treatment for patients with severe sepsis. J Endotoxin Res. 2001;7(4):310-4. DMUFCQG RU https://pubmed.ncbi.nlm.nih.gov/11717588 DMB1UYV DI DMB1UYV DMB1UYV DN IC-485 DMB1UYV MI TTV5CGO DMB1UYV MN Phosphodiesterase 4 (PDE4) DMB1UYV MT DTT DMB1UYV MA Inhibitor DMB1UYV RN Emerging drugs for the treatment of chronic obstructive pulmonary disease. Expert Opin Emerg Drugs. 2006 May;11(2):275-91. DMB1UYV RU https://pubmed.ncbi.nlm.nih.gov/16634702 DMP925B DI DMP925B DMP925B DN ICA-105665 DMP925B MI TTIVDM3 DMP925B MN Voltage-gated potassium channel Kv7.3 (KCNQ3) DMP925B MT DTT DMP925B MA Activator DMP925B RN New molecular targets for antiepileptic drugs: alpha(2)delta, SV2A, and K(v)7/KCNQ/M potassium channels. Curr Neurol Neurosci Rep. 2008 Jul;8(4):345-52. DMP925B RU https://pubmed.ncbi.nlm.nih.gov/18590620 DMRFY7I DI DMRFY7I DMRFY7I DN ICA-17043 DMRFY7I MI TTMNI76 DMRFY7I MN Calcium-activated potassium channel (KCN) DMRFY7I MT DTT DMRFY7I MA Inhibitor DMRFY7I RN Novel inhibitors of the Gardos channel for the treatment of sickle cell disease. J Med Chem. 2008 Feb 28;51(4):976-82. DMRFY7I RU https://pubmed.ncbi.nlm.nih.gov/18232633 DMRFY7I DI DMRFY7I DMRFY7I DN ICA-17043 DMRFY7I MI TT7M9I6 DMRFY7I MN Calcium-activated potassium channel KCa3.1 (KCNN4) DMRFY7I MT DTT DMRFY7I MA Modulator DMRFY7I RN Senicapoc (ICA-17043): a potential therapy for the prevention and treatment of hemolysis-associated complications in sickle cell anemia.Expert Opin Investig Drugs.2009 Feb;18(2):231-9. DMRFY7I RU https://www.ncbi.nlm.nih.gov/pubmed/19236269 DMGHQ37 DI DMGHQ37 DMGHQ37 DN Icaritin DMGHQ37 MI TTZAYWL DMGHQ37 MN Estrogen receptor (ESR) DMGHQ37 MT DTT DMGHQ37 MA Modulator DMGHQ37 RN A novel prenylflavone restricts breast cancer cell growth through AhR-mediated destabilization of ER protein.Carcinogenesis.2012 May;33(5):1089-97. DMGHQ37 RU https://www.ncbi.nlm.nih.gov/pubmed/22345291 DMC13BQ DI DMC13BQ DMC13BQ DN ICO-25 DMC13BQ MI TTBHFYQ DMC13BQ MN Mucin-1 (MUC1) DMC13BQ MT DTT DMC13BQ RN The role of epithelial antigens in diagnosis and staging of breast cancer. Arkh Patol. 2002 Nov-Dec;64(6):13-5. DMC13BQ RU https://pubmed.ncbi.nlm.nih.gov/12534220 DMTXNZK DI DMTXNZK DMTXNZK DN Icofungipen DMTXNZK MI TT2GPK3 DMTXNZK MN DNA topoisomerase (TOP) DMTXNZK MT DTT DMTXNZK MA Inhibitor DMTXNZK RN Crystallization and preliminary X-ray analysis of anti-cancer agent 3-(9-acridinylamino)-5-(hydroxymethyl)aniline complexed with the DNA hexamer d(CGTACG)2. Biochim Biophys Acta. 2003 Jan 3;1625(1):27-9. DMTXNZK RU https://pubmed.ncbi.nlm.nih.gov/12527422 DMTXNZK DI DMTXNZK DMTXNZK DN Icofungipen DMTXNZK MI TTBZHDM DMTXNZK MN Fungal Isoleucyl t-RNA synthetase (Fung ILS1) DMTXNZK MT DTT DMTXNZK MA Modulator DMTXNZK RN Efficacy, plasma pharmacokinetics, and safety of icofungipen, an inhibitor of Candida isoleucyl-tRNA synthetase, in treatment of experimental disseminated candidiasis in persistently neutropenic rabbits. Antimicrob Agents Chemother. 2005 May;49(5):2084-92. DMTXNZK RU https://pubmed.ncbi.nlm.nih.gov/15855534 DM524GR DI DM524GR DM524GR DN ICP-192 DM524GR MI TT0LF7H DM524GR MN Fibroblast growth factor receptor (FGFR) DM524GR MT DTT DM524GR MA Inhibitor DM524GR RN Clinical pipeline report, company report or official report of InnoCare Pharma. DM524GR RU https://www.innocarepharma.com/en/pipeline/our-pipeline/ DM7XIAJ DI DM7XIAJ DM7XIAJ DN ID-93/GLA-SE DM7XIAJ MI TTVH0YQ DM7XIAJ MN Mycobacterium Fusion protein Rv2608-Rv3619-Rv3620-Rv1813 (MycB antigens) DM7XIAJ MT DTT DM7XIAJ MA Modulator DM7XIAJ RN US patent application no. US20150182612 A1. DM7XIAJ RU https://www.google.co.in/patents/US20150182612 DMABRXY DI DMABRXY DMABRXY DN IDM-2101 DMABRXY MI TTY6DTE DMABRXY MN Carcinoembryonic antigen CEA (CD66e) DMABRXY MT DTT DMABRXY RN Induction of immune responses and clinical efficacy in a phase II trial of IDM-2101, a 10-epitope cytotoxic T-lymphocyte vaccine, in metastatic non-small-cell lung cancer. J Clin Oncol. 2008 Sep 20;26(27):4418-25. DMABRXY RU https://pubmed.ncbi.nlm.nih.gov/18802154 DMABRXY DI DMABRXY DMABRXY DN IDM-2101 DMABRXY MI TTWSKHD DMABRXY MN Melanoma-associated antigen 3 (MAGEA3) DMABRXY MT DTT DMABRXY RN Induction of immune responses and clinical efficacy in a phase II trial of IDM-2101, a 10-epitope cytotoxic T-lymphocyte vaccine, in metastatic non-small-cell lung cancer. J Clin Oncol. 2008 Sep 20;26(27):4418-25. DMABRXY RU https://pubmed.ncbi.nlm.nih.gov/18802154 DMSRC5D DI DMSRC5D DMSRC5D DN IDX899 DMSRC5D MI TT84ETX DMSRC5D MN Human immunodeficiency virus Reverse transcriptase (HIV RT) DMSRC5D MT DTT DMSRC5D MA Modulator DMSRC5D RN Unexpected finding of delayed-onset seizures in HIV-positive, treatment-experienced subjects in the Phase IIb evaluation of fosdevirine (GSK2248761).Antivir Ther.2014;19(1):69-78. DMSRC5D RU https://www.ncbi.nlm.nih.gov/pubmed/24158593 DMGWNCJ DI DMGWNCJ DMGWNCJ DN Ifabotuzumab DMGWNCJ MI TTHS2LR DMGWNCJ MN Ephrin type-A receptor 3 (EPHA3) DMGWNCJ MT DTT DMGWNCJ MA Antagonist DMGWNCJ RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMGWNCJ RU http://phrma-docs.phrma.org/files/dmfile/MID_Immuno-Oncology-2017_Drug-List1.pdf DMZP84Y DI DMZP84Y DMZP84Y DN Ifetroban sodium DMZP84Y MI TT2O84V DMZP84Y MN Thromboxane A2 receptor (TBXA2R) DMZP84Y MT DTT DMZP84Y MA Antagonist DMZP84Y RN AT-1 receptor antagonism modifies the mediation of endothelin-1, thromboxane A2, and catecholamines in the renal constrictor response to angiotensin II. Kidney Int Suppl. 2005 Jan;(93):S3-9. DMZP84Y RU https://pubmed.ncbi.nlm.nih.gov/15613065 DM4H8EZ DI DM4H8EZ DM4H8EZ DN IFN-alpha DM4H8EZ MI TT95SOA DM4H8EZ MN Interferon alpha (IFNA) DM4H8EZ MT DTT DM4H8EZ MA Modulator DM4H8EZ RN WO patent application no. 2009,0153,36, Controlled release interferon drug products and treatment of hcv infection using same. DM4H8EZ RU http://worldwide.espacenet.com/publicationDetails/biblio?DB=worldwide.espacenet.com&II=0&ND=3&adjacent=true&locale=en_EP&FT=D&date=20090129&CC=WO&NR=2009015336A2&KC=A2 DMHI36A DI DMHI36A DMHI36A DN IFX-1 DMHI36A MI TTKANGO DMHI36A MN Complement C5 (CO5) DMHI36A MT DTT DMHI36A MA Inhibitor DMHI36A RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMHI36A RU http://phrma-docs.phrma.org/files/dmfile/MID_Skin_Diseases_2018_9_FINAL.pdf DMH97XA DI DMH97XA DMH97XA DN Igmesine DMH97XA MI TTA7UJC DMH97XA MN Alpha-1-antitrypsin (SERPINA1) DMH97XA MT DTT DMH97XA MA Modulator DMH97XA RN Emerging drugs for the treatment of chronic obstructive pulmonary disease. Expert Opin Emerg Drugs. 2006 May;11(2):275-91. DMH97XA RU https://pubmed.ncbi.nlm.nih.gov/16634702 DMH97XA DI DMH97XA DMH97XA DN Igmesine DMH97XA MI TT5TPI6 DMH97XA MN Opioid receptor sigma 1 (OPRS1) DMH97XA MT DTT DMH97XA MA Agonist DMH97XA RN Antiamnesic and neuroprotective effects of donepezil against learning impairments induced in mice by exposure to carbon monoxide gas. J Pharmacol Exp Ther. 2006 Jun;317(3):1307-19. DMH97XA RU https://pubmed.ncbi.nlm.nih.gov/16551835 DMIHQ5G DI DMIHQ5G DMIHQ5G DN IL-2/CD40L-expressing leukemia vaccine DMIHQ5G MI TTF89GD DMIHQ5G MN Interleukin-2 (IL2) DMIHQ5G MT DTT DMIHQ5G RN Immunotherapy of high-risk acute leukemia with a recipient (autologous) vaccine expressing transgenic human CD40L and IL-2 after chemotherapy and a... Blood. 2006 Feb 15;107(4):1332-41. DMIHQ5G RU https://pubmed.ncbi.nlm.nih.gov/16249392 DMIHQ5G DI DMIHQ5G DMIHQ5G DN IL-2/CD40L-expressing leukemia vaccine DMIHQ5G MI TTIJP3Q DMIHQ5G MN TNF related activation protein (CD40LG) DMIHQ5G MT DTT DMIHQ5G RN Immunotherapy of high-risk acute leukemia with a recipient (autologous) vaccine expressing transgenic human CD40L and IL-2 after chemotherapy and a... Blood. 2006 Feb 15;107(4):1332-41. DMIHQ5G RU https://pubmed.ncbi.nlm.nih.gov/16249392 DM1E4VP DI DM1E4VP DM1E4VP DN IL-21 DM1E4VP MI TT9QEJ6 DM1E4VP MN Interleukin-21 (IL21) DM1E4VP MT DTT DM1E4VP MA Modulator DM1E4VP RN National Cancer Institute Drug Dictionary (drug id 409696). DM1E4VP RU http://www.cancer.gov/publications/dictionaries/cancer-drug?cdrid=409696 DMYEGRH DI DMYEGRH DMYEGRH DN IL-4R DMYEGRH MI TTLGTKB DMYEGRH MN Interleukin-4 (IL4) DMYEGRH MT DTT DMYEGRH MA Inhibitor DMYEGRH RN Efficacy of soluble IL-4 receptor for the treatment of adults with asthma. J Allergy Clin Immunol. 2001 Jun;107(6):963-70. DMYEGRH RU https://pubmed.ncbi.nlm.nih.gov/11398072 DMDNHRA DI DMDNHRA DMDNHRA DN Ilodecakin DMDNHRA MI TTT0Q1F DMDNHRA MN Interleukin-10 (IL10) DMDNHRA MT DTT DMDNHRA MA Modulator DMDNHRA RN Ilodecakin. Schering-Plough Corp. IDrugs. 1999 Oct;2(10):1045-58. DMDNHRA RU https://pubmed.ncbi.nlm.nih.gov/16118714 DMUJ1WV DI DMUJ1WV DMUJ1WV DN IMCgp100 DMUJ1WV MI TT8MK59 DMUJ1WV MN Melanocytes lineage-specific antigen GP100 (PMEL) DMUJ1WV MT DTT DMUJ1WV MA Modulator DMUJ1WV RN Bi-specific TCR-anti CD3 redirected T-cell targeting of NY-ESO-1- and LAGE-1-positive tumors DMUJ1WV RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3624013 DMUJ1WV DI DMUJ1WV DMUJ1WV DN IMCgp100 DMUJ1WV MI TT7AKW1 DMUJ1WV MN T-cell receptor (TCR) DMUJ1WV MT DTT DMUJ1WV MA Modulator DMUJ1WV RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMUJ1WV RU http://phrma-docs.phrma.org/files/dmfile/MID_Immuno-Oncology-2017_Drug-List1.pdf DMUJ1WV DI DMUJ1WV DMUJ1WV DN IMCgp100 DMUJ1WV MI TTV3XPL DMUJ1WV MN T-cell surface glycoprotein CD3 gamma (CD3G) DMUJ1WV MT DTT DMUJ1WV MA Inhibitor DMUJ1WV RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMUJ1WV RU http://phrma-docs.phrma.org/files/dmfile/MID_Skin_Diseases_2018_9_FINAL.pdf DMU1MR9 DI DMU1MR9 DMU1MR9 DN IMD-1041 DMU1MR9 MI TTJ3E9X DMU1MR9 MN Inhibitor of nuclear factor kappa-B kinase beta (IKKB) DMU1MR9 MT DTT DMU1MR9 MA Inhibitor DMU1MR9 RN Inhibition of I B phosphorylation prevents load-induced cardiac dysfunction in mice. Am J Physiol Heart Circ Physiol. 2012 Dec 15;303(12):H1435-45. DMU1MR9 RU https://pubmed.ncbi.nlm.nih.gov/23042949 DMMQFG2 DI DMMQFG2 DMMQFG2 DN Imeglimin DMMQFG2 MI TTLAFZV DMMQFG2 MN AMP-activated protein kinase (AMPK) DMMQFG2 MT DTT DMMQFG2 MA Modulator DMMQFG2 RN Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800032542) DMMQFG2 RU http://adisinsight.springer.com/drugs/800032542 DML9AVG DI DML9AVG DML9AVG DN IMG-7289 DML9AVG MI TTNR0UQ DML9AVG MN Lysine-specific histone demethylase 1 (LSD) DML9AVG MT DTT DML9AVG MA Inhibitor DML9AVG RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DML9AVG RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DMNJ491 DI DMNJ491 DMNJ491 DN IMGN529 DMNJ491 MI TTFCW29 DMNJ491 MN Leukocyte antigen CD37 (CD37) DMNJ491 MT DTT DMNJ491 RN The CD37-targeted antibody-drug conjugate IMGN529 is highly active against human CLL and in a novel CD37 transgenic murine leukemia model. Leukemia. 2014 Jul;28(7):1501-10. DMNJ491 RU https://pubmed.ncbi.nlm.nih.gov/24445867 DMIUC3M DI DMIUC3M DMIUC3M DN IMGN901 DMIUC3M MI TTUBJQ3 DMIUC3M MN Neural cell adhesion molecule (NCAM) DMIUC3M MT DTT DMIUC3M MA Modulator DMIUC3M RN Lorvotuzumab mertansine, a CD56-targeting antibody-drug conjugate with potent antitumor activity against small cell lung cancer in human xenograft models. MAbs. 2014 Mar-Apr;6(2):556-66. DMIUC3M RU https://pubmed.ncbi.nlm.nih.gov/24492307 DME3POC DI DME3POC DME3POC DN Imisopasem manganese DME3POC MI TT9O4C5 DME3POC MN Superoxide dismutase Mn (SOD Mn) DME3POC MT DTT DME3POC MA Modulator DME3POC RN The manganese superoxide dismutase mimetic, M40403, protects adult mice from lethal total body irradiation. Free Radic Res. 2010 May;44(5):529-40. DME3POC RU https://pubmed.ncbi.nlm.nih.gov/20298121 DM6IQ3V DI DM6IQ3V DM6IQ3V DN IMO-2055 DM6IQ3V MI TTSHG0T DM6IQ3V MN Toll-like receptor 9 (TLR9) DM6IQ3V MT DTT DM6IQ3V MA Agonist DM6IQ3V RN Clinical pipeline report, company report or official report of Idera Pharmaceuticals (2011). DM6IQ3V RU http://www.iderapharma.com/ DMM549D DI DMM549D DMM549D DN IMO-3100 DMM549D MI TTRJ1K4 DMM549D MN Toll-like receptor 7 (TLR7) DMM549D MT DTT DMM549D MA Modulator DMM549D RN Company report (Iderapharma) DMM549D RU http://ir.iderapharma.com/phoenix.zhtml?c=208904&p=irol-newsArticle&ID=1816887 DMM549D DI DMM549D DMM549D DN IMO-3100 DMM549D MI TTSHG0T DMM549D MN Toll-like receptor 9 (TLR9) DMM549D MT DTT DMM549D MA Modulator DMM549D RN Company report (Iderapharma) DMM549D RU http://ir.iderapharma.com/phoenix.zhtml?c=208904&p=irol-newsArticle&ID=1816887 DMDPNCJ DI DMDPNCJ DMDPNCJ DN IMO-8400 DMDPNCJ MI TTOK0LR DMDPNCJ MN Toll-like receptor (TLR) DMDPNCJ MT DTT DMDPNCJ MA Antagonist DMDPNCJ RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMDPNCJ RU http://phrma-docs.phrma.org/sites/default/files/pdf/medicines-in-development-drug-list-rare-diseases.pdf DMTN16K DI DMTN16K DMTN16K DN Implitapide DMTN16K MI TTUS1RD DMTN16K MN Microsomal triglyceride transfer protein (MTTP) DMTN16K MT DTT DMTN16K MA Inhibitor DMTN16K RN Novel nonstatin strategies to lower low-density lipoprotein cholesterol. Curr Atheroscler Rep. 2009 Jan;11(1):67-70. DMTN16K RU https://pubmed.ncbi.nlm.nih.gov/19080731 DMB1N6P DI DMB1N6P DMB1N6P DN Impoyz DMB1N6P MI DE4LYSA DMB1N6P MN Cytochrome P450 3A4 (CYP3A4) DMB1N6P MT DME DMB1N6P MA Metabolism DMB1N6P RN Cytochrome p450: a target for drug development for skin diseases. J Invest Dermatol. 2004 Sep;123(3):417-25. DMB1N6P RU https://www.ncbi.nlm.nih.gov/pubmed/?term=15304077 DM15MRZ DI DM15MRZ DM15MRZ DN IMR-687 DM15MRZ MI TTZOEBC DM15MRZ MN Phosphodiesterase 9 (PDE9) DM15MRZ MT DTT DM15MRZ MA Inhibitor DM15MRZ RN Clinical pipeline report, company report or official report of Imara. DM15MRZ RU https://imaratx.com/our-programs/ DMNUXKA DI DMNUXKA DMNUXKA DN INCAGN01876 DMNUXKA MI TTG6LA7 DMNUXKA MN Activation-inducible TNFR family receptor (TNFRSF18) DMNUXKA MT DTT DMNUXKA MA Agonist DMNUXKA RN Clinical pipeline report, company report or official report of Agenus. DMNUXKA RU https://agenusbio.com/pipeline/ DMK7OHI DI DMK7OHI DMK7OHI DN INCAGN01949 DMK7OHI MI TTL31H0 DMK7OHI MN OX40L receptor (CD134) DMK7OHI MT DTT DMK7OHI MA Agonist DMK7OHI RN Sequential therapy with INCAGN01949 followed by ipilimumab and nivolumab in two patients with advanced ovarian carcinoma. Gynecol Oncol Rep. 2020 Oct 1;34:100655. DMK7OHI RU https://pubmed.ncbi.nlm.nih.gov/33083509 DMFG8TI DI DMFG8TI DMFG8TI DN INCB00928 DMFG8TI MI TTJNBQA DMFG8TI MN Activin receptor-like kinase 2 (ALK-2) DMFG8TI MT DTT DMFG8TI MA Inhibitor DMFG8TI RN Clinical pipeline report, company report or official report of Incyte. DMFG8TI RU https://www.incyte.com/what-we-do/pharmaceutical-portfolio DMD9RV3 DI DMD9RV3 DMD9RV3 DN INCB039110 DMD9RV3 MI TT6DM01 DMD9RV3 MN Janus kinase 1 (JAK-1) DMD9RV3 MT DTT DMD9RV3 MA Inhibitor DMD9RV3 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2047). DMD9RV3 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2047 DMD9RV3 DI DMD9RV3 DMD9RV3 DN INCB039110 DMD9RV3 MI TTRMX3V DMD9RV3 MN Janus kinase 2 (JAK-2) DMD9RV3 MT DTT DMD9RV3 MA Inhibitor DMD9RV3 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2048). DMD9RV3 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2048 DMZJP2T DI DMZJP2T DMZJP2T DN INCB50465 DMZJP2T MI TTGBPJE DMZJP2T MN PI3-kinase delta (PIK3CD) DMZJP2T MT DTT DMZJP2T MA Inhibitor DMZJP2T RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMZJP2T RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DMDK0HX DI DMDK0HX DMDK0HX DN INCB54707 DMDK0HX MI TT6DM01 DMDK0HX MN Janus kinase 1 (JAK-1) DMDK0HX MT DTT DMDK0HX MA Inhibitor DMDK0HX RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMDK0HX RU http://phrma-docs.phrma.org/files/dmfile/MID_Skin_Diseases_2018_9_FINAL.pdf DMJN9PU DI DMJN9PU DMJN9PU DN INCB86550 DMJN9PU MI TT8ZLTI DMJN9PU MN Programmed cell death 1 ligand 1 (PD-L1) DMJN9PU MT DTT DMJN9PU MA Inhibitor DMJN9PU RN National Cancer Institute Drug Dictionary (drug name INCB086550). DMJN9PU RU https://www.cancer.gov/publications/dictionaries/cancer-drug/def/pd-l1-inhibitor-incb086550 DM6OFJ8 DI DM6OFJ8 DM6OFJ8 DN Indibulin DM6OFJ8 MI TTML2WA DM6OFJ8 MN Tubulin (TUB) DM6OFJ8 MT DTT DM6OFJ8 MA Stablizer DM6OFJ8 RN 2011 Pipeline of ZioPharm. DM6OFJ8 RU http://www.ziopharm.com/clinical_dev.php DM9SX6Y DI DM9SX6Y DM9SX6Y DN Indisulam DM9SX6Y MI TT2LVK8 DM9SX6Y MN Carbonic anhydrase IX (CA-IX) DM9SX6Y MT DTT DM9SX6Y MA Modulator DM9SX6Y RN Carbonic anhydrase inhibitors: E7070, a sulfonamide anticancer agent, potently inhibits cytosolic isozymes I and II, and transmembrane, tumor-assoc... Bioorg Med Chem Lett. 2004 Jan 5;14(1):217-23. DM9SX6Y RU https://www.ncbi.nlm.nih.gov/pubmed/14684331 DM9SX6Y DI DM9SX6Y DM9SX6Y DN Indisulam DM9SX6Y MI DE5IED8 DM9SX6Y MN Cytochrome P450 2C9 (CYP2C9) DM9SX6Y MT DME DM9SX6Y MA Metabolism DM9SX6Y RN PK/PD model of indisulam and capecitabine: interaction causes excessive myelosuppression. Clin Pharmacol Ther. 2008 Jun;83(6):829-39. DM9SX6Y RU https://www.ncbi.nlm.nih.gov/pubmed/?term=17851564 DM9SX6Y DI DM9SX6Y DM9SX6Y DN Indisulam DM9SX6Y MI DEGTFWK DM9SX6Y MN Mephenytoin 4-hydroxylase (CYP2C19) DM9SX6Y MT DME DM9SX6Y MA Metabolism DM9SX6Y RN CYP2C9 and CYP2C19 polymorphic forms are related to increased indisulam exposure and higher risk of severe hematologic toxicity. Clin Cancer Res. 2007 May 15;13(10):2970-6. DM9SX6Y RU https://www.ncbi.nlm.nih.gov/pubmed/?term=17504998 DMU5SZP DI DMU5SZP DMU5SZP DN Inecalcitol oral DMU5SZP MI TTK59TV DMU5SZP MN Vitamin D3 receptor (VDR) DMU5SZP MT DTT DMU5SZP MA Agonist DMU5SZP RN Inecalcitol, an analog of 1,25D3, displays enhanced antitumor activity through the induction of apoptosis in a squamous cell carcinoma model system. Cell Cycle. 2013 Mar 1;12(5):743-52. DMU5SZP RU https://pubmed.ncbi.nlm.nih.gov/23388458 DMEO9Y7 DI DMEO9Y7 DMEO9Y7 DN INGAP peptide DMEO9Y7 MI TTGMYVE DMEO9Y7 MN Phosphofructokinase 2 (PFK2) DMEO9Y7 MT DTT DMEO9Y7 MA Modulator DMEO9Y7 RN A Pentadecapeptide Fragment of Islet Neogenesis-Associated Protein Increases Beta-Cell Mass and Reverses Diabetes in C57BL/6J Mice. Ann Surg. 2004 November; 240(5): 875-884. DMEO9Y7 RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1356495/ DMF7J6D DI DMF7J6D DMF7J6D DN INGN-225 DMF7J6D MI TT7SBF5 DMF7J6D MN Cellular tumor antigen p53 (TP53) DMF7J6D MT DTT DMF7J6D RN INGN-225: a dendritic cell-based p53 vaccine (Ad.p53-DC) in small cell lung cancer: observed association between immune response and enhanced chemotherapy effect. Expert Opin Biol Ther. 2010 Jun;10(6):983-91. DMF7J6D RU https://pubmed.ncbi.nlm.nih.gov/20420527 DM6P91T DI DM6P91T DM6P91T DN INGN-241 DM6P91T MI TT1EPXZ DM6P91T MN Interleukin-24 (IL24) DM6P91T MT DTT DM6P91T MA Inhibitor DM6P91T RN Intratumoral injection of INGN 241, a nonreplicating adenovector expressing the melanoma-differentiation associated gene-7 (mda-7/IL24): biologic outcome in advanced cancer patients. Mol Ther. 2005 Jan;11(1):160-72. DM6P91T RU https://pubmed.ncbi.nlm.nih.gov/15585417 DMGO7QT DI DMGO7QT DMGO7QT DN INK128 DMGO7QT MI TTCJG29 DMGO7QT MN Serine/threonine-protein kinase mTOR (mTOR) DMGO7QT MT DTT DMGO7QT MA Inhibitor DMGO7QT RN 2011 Pipeline of Intellikine. DMGO7QT RU http://www.intellikine.com/pipeline/ DMKRGVJ DI DMKRGVJ DMKRGVJ DN INS-1 DMKRGVJ MI TTZ7WFL DMKRGVJ MN Glucose metabolism (Glucose metab) DMKRGVJ MT DTT DMKRGVJ MA Modulator DMKRGVJ RN Herbal constituent sequoyitol improves hyperglycemia and glucose intolerance by targeting hepatocytes, adipocytes, and beta-cells. Am J Physiol Endocrinol Metab. 2012 April 15; 302(8): E932-E940. DMKRGVJ RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3330724/ DMF93RQ DI DMF93RQ DMF93RQ DN INS-37217 DMF93RQ MI TTOZHQC DMF93RQ MN P2Y purinoceptor 2 (P2RY2) DMF93RQ MT DTT DMF93RQ MA Agonist DMF93RQ RN Emerging drugs for the treatment of chronic obstructive pulmonary disease. Expert Opin Emerg Drugs. 2006 May;11(2):275-91. DMF93RQ RU https://pubmed.ncbi.nlm.nih.gov/16634702 DMKZUVC DI DMKZUVC DMKZUVC DN INS-50589 DMKZUVC MI TTZ1DT0 DMKZUVC MN P2Y purinoceptor 12 (P2RY12) DMKZUVC MT DTT DMKZUVC MA Modulator DMKZUVC RN Rapid and reversible modulation of platelet function in man by a novel P2Y(12) ADP-receptor antagonist, INS50589. Platelets. 2007 Aug;18(5):346-56. DMKZUVC RU https://pubmed.ncbi.nlm.nih.gov/17654304 DMNKAFQ DI DMNKAFQ DMNKAFQ DN Instiladrin DMNKAFQ MI TTSIUJ9 DMNKAFQ MN Interferon-alpha 2 (IFNA2) DMNKAFQ MT DTT DMNKAFQ MA Modulator DMNKAFQ RN ClinicalTrials.gov (NCT01687244) Intravesical Administration of rAd-IFN/Syn3 in Patients With BCG-Refractory or Relapsed Bladder Cancer. U.S. National Institutes of Health. DMNKAFQ RU https://clinicaltrials.gov/ct2/show/NCT01687244 DMYTKF5 DI DMYTKF5 DMYTKF5 DN Interferon DMYTKF5 MI TT6ONYI DMYTKF5 MN Interferon (IFN) DMYTKF5 MT DTT DMYTKF5 MA Modulator DMYTKF5 RN Low-dose oral interferon alpha as prophylaxis against viral respiratory illness: a double-blind, parallel controlled trial during an influenza pandemic year. Influenza Other Respir Viruses. 2013 Sep;7(5):854-62. DMYTKF5 RU https://pubmed.ncbi.nlm.nih.gov/23398960 DMVACTU DI DMVACTU DMVACTU DN Interferon alpha-2b DMVACTU MI TTSIUJ9 DMVACTU MN Interferon-alpha 2 (IFNA2) DMVACTU MT DTT DMVACTU MA Modulator DMVACTU RN Clinical pipeline report, company report or official report of Avarx. DMVACTU RU http://www.avarx.com/AvaRx/SubDomains/Company271/Listings/bucketc9a4f99040669fa206037a416235/Public.Listing.display.html DMQSA7H DI DMQSA7H DMQSA7H DN Interferon beta 1a DMQSA7H MI TT4TZ8J DMQSA7H MN Interferon-beta (IFNB1) DMQSA7H MT DTT DMQSA7H MA Modulator DMQSA7H RN Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41. DMQSA7H RU https://www.ncbi.nlm.nih.gov/pubmed/15950434 DM8YF01 DI DM8YF01 DM8YF01 DN Interferon-alpha lozenge DM8YF01 MI TT95SOA DM8YF01 MN Interferon alpha (IFNA) DM8YF01 MT DTT DM8YF01 MA Modulator DM8YF01 RN Interferon-alpha. Amarillo Biosciences. Curr Opin Investig Drugs. 2002 May;3(5):693-7. DM8YF01 RU https://pubmed.ncbi.nlm.nih.gov/12090541 DMBXEG9 DI DMBXEG9 DMBXEG9 DN Intetumumab DMBXEG9 MI TT69TQN DMBXEG9 MN Integrin alpha-V/beta-3 (ITGAV/B3) DMBXEG9 MT DTT DMBXEG9 MA Modulator DMBXEG9 RN A randomised, phase II study of intetumumab, an anti-alphav-integrin mAb, alone and with dacarbazine in stage IV melanoma. Br J Cancer. 2011 Jul 26;105(3):346-52. DMBXEG9 RU https://pubmed.ncbi.nlm.nih.gov/21750555 DMSTJ6Q DI DMSTJ6Q DMSTJ6Q DN INX-189 DMSTJ6Q MI TTMVBWH DMSTJ6Q MN Hepatitis C virus RNA-directed RNA polymerase (HCV NS5B) DMSTJ6Q MT DTT DMSTJ6Q MA Inhibitor DMSTJ6Q RN Clinical pipeline report, company report or official report of Bristol-Myers Squibb. DMSTJ6Q RU http://news.bms.com/press-release/financial-news/bristol-myers-squibb-discontinues-development-bms-986094-investigationa DMNW0DG DI DMNW0DG DMNW0DG DN Iodine-131-tositumomab DMNW0DG MI TTUE541 DMNW0DG MN Leukocyte surface antigen Leu-16 (CD20) DMNW0DG MT DTT DMNW0DG RN Rituximab blocks binding of radiolabeled anti-CD20 antibodies (Ab) but not radiolabeled anti-CD45 Ab. Blood. 2008 Aug 1;112(3):830-5. DMNW0DG RU https://pubmed.ncbi.nlm.nih.gov/18502830 DM5F0QY DI DM5F0QY DM5F0QY DN IONIS-416858 DM5F0QY MI TTDM4ZU DM5F0QY MN Factor XI messenger RNA (F11 mRNA) DM5F0QY MT DTT DM5F0QY MA Inhibitor DM5F0QY RN Clinical pipeline report, company report or official report of Ionis Pharmaceuticals. DM5F0QY RU https://www.ionispharma.com/ionis-innovation/pipeline/ DM6PDX2 DI DM6PDX2 DM6PDX2 DN IONIS-C9Rx DM6PDX2 MI TTA4SHR DM6PDX2 MN C9orf72 messenger RNA (C9orf72 mRNA) DM6PDX2 MT DTT DM6PDX2 MA Inhibitor DM6PDX2 RN Clinical pipeline report, company report or official report of Ionis Pharmaceuticals. DM6PDX2 RU https://www.ionispharma.com/ionis-innovation/pipeline/ DM5LM3O DI DM5LM3O DM5LM3O DN IONIS-DNM2-2.5Rx DM5LM3O MI TTVRA5G DM5LM3O MN DNM2 messenger RNA (DNM2 mRNA) DM5LM3O MT DTT DM5LM3O MA Inhibitor DM5LM3O RN Clinical pipeline report, company report or official report of Ionis Pharmaceuticals. DM5LM3O RU https://www.ionispharma.com/ionis-innovation/pipeline/ DMJ2763 DI DMJ2763 DMJ2763 DN IONIS-FB-LRx DMJ2763 MI TT3SGK7 DMJ2763 MN CFB messenger RNA (CFB mRNA) DMJ2763 MT DTT DMJ2763 MA Inhibitor DMJ2763 RN Clinical pipeline report, company report or official report of Ionis Pharmaceuticals. DMJ2763 RU https://www.ionispharma.com/ionis-innovation/pipeline/ DMWV2N1 DI DMWV2N1 DMWV2N1 DN IONIS-GCCRRX DMWV2N1 MI TTYRL6O DMWV2N1 MN Glucocorticoid receptor (NR3C1) DMWV2N1 MT DTT DMWV2N1 MA Antagonist DMWV2N1 RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMWV2N1 RU http://phrma-docs.phrma.org/files/dmfile/mid-diabetes-drug-list.pdf DMB4GD9 DI DMB4GD9 DMB4GD9 DN IONIS-GCGR-Rx DMB4GD9 MI TTLMJSC DMB4GD9 MN Glucagon receptor messenger RNA (GCGR mRNA) DMB4GD9 MT DTT DMB4GD9 MA Inhibitor DMB4GD9 RN Clinical pipeline report, company report or official report of Ionis Pharmaceuticals. DMB4GD9 RU https://www.ionispharma.com/ionis-innovation/pipeline/ DMGTJUP DI DMGTJUP DMGTJUP DN IONIS-PTP1BRX DMGTJUP MI TTMS7KP DMGTJUP MN Protein-tyrosine phosphatase 1B (PTP1B) DMGTJUP MT DTT DMGTJUP MA Inhibitor DMGTJUP RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMGTJUP RU http://phrma-docs.phrma.org/files/dmfile/mid-diabetes-drug-list.pdf DM7VJE1 DI DM7VJE1 DM7VJE1 DN IONIS-TMPRSS6-LRx DM7VJE1 MI TTNIUKC DM7VJE1 MN TMPRSS6 messenger RNA (TMPRSS6 mRNA) DM7VJE1 MT DTT DM7VJE1 MA Inhibitor DM7VJE1 RN Clinical pipeline report, company report or official report of Ionis Pharmaceuticals. DM7VJE1 RU https://www.ionispharma.com/ionis-innovation/pipeline/ DM5TMYC DI DM5TMYC DM5TMYC DN iOWH032 DM5TMYC MI TTRLZHP DM5TMYC MN cAMP-dependent chloride channel (CFTR) DM5TMYC MT DTT DM5TMYC MA Inhibitor DM5TMYC RN Developing novel antisecretory drugs to treat infectious diarrhea. Future Med Chem. 2011 Aug;3(10):1317-25. DM5TMYC RU https://pubmed.ncbi.nlm.nih.gov/21859305 DMANRGW DI DMANRGW DMANRGW DN IP10 C8 DMANRGW MI TTPHMWB DMANRGW MN Aminopeptidase N (ANPEP) DMANRGW MT DTT DMANRGW MA Modulator DMANRGW RN Recent insights into the role of dipeptidyl aminopeptidase IV (DPIV) and aminopeptidase N (APN) families in immune functions. Clin Chem Lab Med. 2009;47(3):253-61. DMANRGW RU https://pubmed.ncbi.nlm.nih.gov/19327105 DMANRGW DI DMANRGW DMANRGW DN IP10 C8 DMANRGW MI TTDIGC1 DMANRGW MN Dipeptidyl peptidase 4 (DPP-4) DMANRGW MT DTT DMANRGW MA Modulator DMANRGW RN Recent insights into the role of dipeptidyl aminopeptidase IV (DPIV) and aminopeptidase N (APN) families in immune functions. Clin Chem Lab Med. 2009;47(3):253-61. DMANRGW RU https://pubmed.ncbi.nlm.nih.gov/19327105 DMDUVCZ DI DMDUVCZ DMDUVCZ DN IPH-2101 DMDUVCZ MI TT4UXPE DMDUVCZ MN MHC class I NK cell receptor 2DL1 (CD158A) DMDUVCZ MT DTT DMDUVCZ MA Modulator DMDUVCZ RN Daratumumab-mediated lysis of primary multiple myeloma cells is enhanced in combination with the human anti-KIR antibody IPH2102 and lenalidomide. Haematologica. 2015 Feb;100(2):263-8. DMDUVCZ RU https://pubmed.ncbi.nlm.nih.gov/25510242 DMDUVCZ DI DMDUVCZ DMDUVCZ DN IPH-2101 DMDUVCZ MI TTU0P73 DMDUVCZ MN MHC class I NK cell receptor 2DL2 (CD158b1) DMDUVCZ MT DTT DMDUVCZ MA Modulator DMDUVCZ RN Daratumumab-mediated lysis of primary multiple myeloma cells is enhanced in combination with the human anti-KIR antibody IPH2102 and lenalidomide. Haematologica. 2015 Feb;100(2):263-8. DMDUVCZ RU https://pubmed.ncbi.nlm.nih.gov/25510242 DMDUVCZ DI DMDUVCZ DMDUVCZ DN IPH-2101 DMDUVCZ MI TTEX3SI DMDUVCZ MN MHC class I NK cell receptor 2DL3 (CD158b2) DMDUVCZ MT DTT DMDUVCZ MA Modulator DMDUVCZ RN Daratumumab-mediated lysis of primary multiple myeloma cells is enhanced in combination with the human anti-KIR antibody IPH2102 and lenalidomide. Haematologica. 2015 Feb;100(2):263-8. DMDUVCZ RU https://pubmed.ncbi.nlm.nih.gov/25510242 DMDUVCZ DI DMDUVCZ DMDUVCZ DN IPH-2101 DMDUVCZ MI TTVWAGF DMDUVCZ MN MHC class I NK cell receptor 2DS1 (CD158h) DMDUVCZ MT DTT DMDUVCZ MA Modulator DMDUVCZ RN Daratumumab-mediated lysis of primary multiple myeloma cells is enhanced in combination with the human anti-KIR antibody IPH2102 and lenalidomide. Haematologica. 2015 Feb;100(2):263-8. DMDUVCZ RU https://pubmed.ncbi.nlm.nih.gov/25510242 DMDUVCZ DI DMDUVCZ DMDUVCZ DN IPH-2101 DMDUVCZ MI TTV3CFI DMDUVCZ MN MHC class I NK cell receptor 2DS2 (CD158j) DMDUVCZ MT DTT DMDUVCZ MA Modulator DMDUVCZ RN Daratumumab-mediated lysis of primary multiple myeloma cells is enhanced in combination with the human anti-KIR antibody IPH2102 and lenalidomide. Haematologica. 2015 Feb;100(2):263-8. DMDUVCZ RU https://pubmed.ncbi.nlm.nih.gov/25510242 DMPBR0D DI DMPBR0D DMPBR0D DN IPH-2102 DMPBR0D MI TT4UXPE DMPBR0D MN MHC class I NK cell receptor 2DL1 (CD158A) DMPBR0D MT DTT DMPBR0D MA Antagonist DMPBR0D RN Daratumumab-mediated lysis of primary multiple myeloma cells is enhanced in combination with the human anti-KIR antibody IPH2102 and lenalidomide. Haematologica. 2015 Feb;100(2):263-8. DMPBR0D RU https://pubmed.ncbi.nlm.nih.gov/25510242 DMPBR0D DI DMPBR0D DMPBR0D DN IPH-2102 DMPBR0D MI TTU0P73 DMPBR0D MN MHC class I NK cell receptor 2DL2 (CD158b1) DMPBR0D MT DTT DMPBR0D MA Antagonist DMPBR0D RN Daratumumab-mediated lysis of primary multiple myeloma cells is enhanced in combination with the human anti-KIR antibody IPH2102 and lenalidomide. Haematologica. 2015 Feb;100(2):263-8. DMPBR0D RU https://pubmed.ncbi.nlm.nih.gov/25510242 DMPBR0D DI DMPBR0D DMPBR0D DN IPH-2102 DMPBR0D MI TTEX3SI DMPBR0D MN MHC class I NK cell receptor 2DL3 (CD158b2) DMPBR0D MT DTT DMPBR0D MA Antagonist DMPBR0D RN Daratumumab-mediated lysis of primary multiple myeloma cells is enhanced in combination with the human anti-KIR antibody IPH2102 and lenalidomide. Haematologica. 2015 Feb;100(2):263-8. DMPBR0D RU https://pubmed.ncbi.nlm.nih.gov/25510242 DMQH2SF DI DMQH2SF DMQH2SF DN IPH4102 DMQH2SF MI TTQH3N0 DMQH2SF MN MHC class I NK cell receptor 3DL2 (CD158k) DMQH2SF MT DTT DMQH2SF MA Antagonist DMQH2SF RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMQH2SF RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DMG5Q7F DI DMG5Q7F DMG5Q7F DN IPI-549 DMG5Q7F MI TTHBTOP DMG5Q7F MN PI3-kinase gamma (PIK3CG) DMG5Q7F MT DTT DMG5Q7F MA Inhibitor DMG5Q7F RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMG5Q7F RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DMW2IF9 DI DMW2IF9 DMW2IF9 DN IR502 DMW2IF9 MI TT7AKW1 DMW2IF9 MN T-cell receptor (TCR) DMW2IF9 MT DTT DMW2IF9 MA Modulator DMW2IF9 RN WO patent application no. 2004,0677,06, Production of multimeric proteins. DMW2IF9 RU http://www.google.com/patents/WO2004067706A2?cl=en DMQ3RWN DI DMQ3RWN DMQ3RWN DN Iralukast DMQ3RWN MI TTGKOY9 DMQ3RWN MN Leukotriene CysLT1 receptor (CYSLTR1) DMQ3RWN MT DTT DMQ3RWN MA Modulator DMQ3RWN RN Pharmacological characterization of the cysteinyl-leukotriene antagonists CGP 45715A (iralukast) and CGP 57698 in human airways in vitro. Br J Pharmacol. 1998 Feb;123(3):590-8. DMQ3RWN RU https://pubmed.ncbi.nlm.nih.gov/9504401 DMI874B DI DMI874B DMI874B DN Iratumumab DMI874B MI TT2GM5R DMI874B MN Lymphocyte activation antigen CD30 (TNFRSF8) DMI874B MT DTT DMI874B RN Utilizing CD30 expression as a rational target for therapy of lymphoma. J Hematol Oncol. 2012; 5(Suppl 1): A2. DMI874B RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3337265/ DMCAFVN DI DMCAFVN DMCAFVN DN IRT-102 DMCAFVN MI TT6IEYX DMCAFVN MN Opioid receptor zeta (OGFR) DMCAFVN MT DTT DMCAFVN MA Modulator DMCAFVN RN The opiate receptor binding interactions of 3H-methionine enkephalin, an opioid peptide. Eur J Pharmacol. 1978 Feb 1;47(3):319-31. DMCAFVN RU https://pubmed.ncbi.nlm.nih.gov/204498 DMODLN7 DI DMODLN7 DMODLN7 DN IRX-2 DMODLN7 MI TTXM6JN DMODLN7 MN Cytokine receptor unspecific (CRF) DMODLN7 MT DTT DMODLN7 MA Modulator DMODLN7 RN Clinical pipeline report, company report or official report of IRX Therapeutics. DMODLN7 RU http://www.irxtherapeutics.com/prod_irx2.html DMHOJ8W DI DMHOJ8W DMHOJ8W DN Isatoribine DMHOJ8W MI TTRJ1K4 DMHOJ8W MN Toll-like receptor 7 (TLR7) DMHOJ8W MT DTT DMHOJ8W MA Agonist DMHOJ8W RN Discovery of ANA975: an oral prodrug of the TLR-7 agonist isatoribine. Nucleosides Nucleotides Nucleic Acids. 2007;26(6-7):635-40. DMHOJ8W RU https://pubmed.ncbi.nlm.nih.gov/18066870 DMBZK3P DI DMBZK3P DMBZK3P DN ISF35 DMBZK3P MI TTIJP3Q DMBZK3P MN TNF related activation protein (CD40LG) DMBZK3P MT DTT DMBZK3P MA Binder DMBZK3P RN Intratumoral injection of Ad-ISF35 (Chimeric CD154) breaks tolerance and induces lymphoma tumor regression. Hum Gene Ther. 2015 Jan;26(1):14-25. DMBZK3P RU https://pubmed.ncbi.nlm.nih.gov/25382101 DMUPD4G DI DMUPD4G DMUPD4G DN ISIS 113715 DMUPD4G MI TTELIN2 DMUPD4G MN PTPN1 messenger RNA (PTPN1 mRNA) DMUPD4G MT DTT DMUPD4G RN Clinical pipeline report, company report or official report of ISIS Pharmaceuticals (2009). DMUPD4G RU http://www.isispharm.com/Pipeline/index.htm DMQ3C05 DI DMQ3C05 DMQ3C05 DN ISIS-APO(a) DMQ3C05 MI TTU9LGY DMQ3C05 MN Apolipoprotein A messenger RNA (LPA mRNA) DMQ3C05 MT DTT DMQ3C05 RN Clinical pipeline report, company report or official report of ISIS Pharmaceuticals. DMQ3C05 RU https://www.isispharm.com/pipeline/isis-apoarx/ DML84CN DI DML84CN DML84CN DN ISIS-CRPRx DML84CN MI TTWRN6M DML84CN MN CRP messenger RNA (CRP mRNA) DML84CN MT DTT DML84CN MA Modulator DML84CN RN Antisense oligonucleotides on neurobehavior, respiratory, and cardiovascular function, and hERG channel current studies. J Pharmacol Toxicol Methods. 2014 Jan-Feb;69(1):49-60. DML84CN RU https://pubmed.ncbi.nlm.nih.gov/24211663 DMRN543 DI DMRN543 DMRN543 DN ISIS-EIF4E DMRN543 MI TTNBTCW DMRN543 MN eIF4E-BP2 messenger RNA (eIF4E-BP2 mRNA) DMRN543 MT DTT DMRN543 RN Clinical pipeline report, company report or official report of ISIS Pharmaceuticals (2011). DMRN543 RU http://www.isispharm.com/index.htm DMNVZDT DI DMNVZDT DMNVZDT DN ISIS-FGFR4 DMNVZDT MI TT1KX2S DMNVZDT MN FGFR4 messenger RNA (FGFR4 mRNA) DMNVZDT MT DTT DMNVZDT RN Clinical pipeline report, company report or official report of ISIS Pharmaceuticals (2011). DMNVZDT RU http://www.isispharm.com/index.htm DMHETPI DI DMHETPI DMHETPI DN ISIS-FXI DMHETPI MI TTDM4ZU DMHETPI MN Factor XI messenger RNA (F11 mRNA) DMHETPI MT DTT DMHETPI RN Clinical pipeline report, company report or official report of ISIS Pharmaceuticals (2011). DMHETPI RU http://www.isispharm.com/index.htm DMICMNU DI DMICMNU DMICMNU DN ISIS-GCCR DMICMNU MI TTOZRK6 DMICMNU MN Glucocorticoid receptor messenger RNA (GCR mRNA) DMICMNU MT DTT DMICMNU RN Clinical pipeline report, company report or official report of ISIS Pharmaceuticals (2011). DMICMNU RU http://www.isispharm.com/index.htm DMHNYWP DI DMHNYWP DMHNYWP DN ISIS-GCGR DMHNYWP MI TTLMJSC DMHNYWP MN Glucagon receptor messenger RNA (GCGR mRNA) DMHNYWP MT DTT DMHNYWP RN Clinical pipeline report, company report or official report of ISIS Pharmaceuticals (2011). DMHNYWP RU http://www.isispharm.com/index.htm DM4RXDQ DI DM4RXDQ DM4RXDQ DN ISIS-HBV DM4RXDQ MI TT43YWN DM4RXDQ MN Hepatitis B virus messenger RNA (HBV mRNA) DM4RXDQ MT DTT DM4RXDQ RN Clinical pipeline report, company report or official report of ISIS Pharmaceuticals. DM4RXDQ RU https://www.isispharm.com/pipeline/isis-hbvrx/ DMJGVXT DI DMJGVXT DMJGVXT DN ISIS-PTP1Brx DMJGVXT MI TTELIN2 DMJGVXT MN PTPN1 messenger RNA (PTPN1 mRNA) DMJGVXT MT DTT DMJGVXT MA Modulator DMJGVXT RN Clinical pipeline report, company report or official report of ISIS Pharmaceuticals. DMJGVXT RU https://www.isispharm.com/pipeline/isis-ptp1brx/ DM2RS0V DI DM2RS0V DM2RS0V DN Isofagomine tartrate DM2RS0V MI TT1B5PU DM2RS0V MN Glucosylceramidase (GBA) DM2RS0V MT DTT DM2RS0V MA Inhibitor DM2RS0V RN Identification of pharmacological chaperones for Gaucher disease and characterization of their effects on beta-glucocerebrosidase by hydrogen/deuterium exchange mass spectrometry. Chembiochem. 2008 Nov 3;9(16):2650-62. DM2RS0V RU https://pubmed.ncbi.nlm.nih.gov/18972510 DMP2BWX DI DMP2BWX DMP2BWX DN Ispinesib DMP2BWX MI TTTRP0H DMP2BWX MN Kinesin-like protein KIF11 (KIF11) DMP2BWX MT DTT DMP2BWX MA Inhibitor DMP2BWX RN Initial testing (stage 1) of the kinesin spindle protein inhibitor ispinesib by the pediatric preclinical testing program. Pediatr Blood Cancer. 2009 Dec 15;53(7):1255-63. DMP2BWX RU https://pubmed.ncbi.nlm.nih.gov/19554570 DMCY9PO DI DMCY9PO DMCY9PO DN Itarnafloxin DMCY9PO MI TTCSZH7 DMCY9PO MN Nucleolin (NCL) DMCY9PO MT DTT DMCY9PO MA Inhibitor DMCY9PO RN Targeting G-quadruplexes in gene promoters: a novel anticancer strategy . Nat Rev Drug Discov. 2011 April; 10(4): 261-275. DMCY9PO RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3119469/ DMDZWPL DI DMDZWPL DMDZWPL DN ITCA-638 DMDZWPL MI TTS2TGF DMDZWPL MN Interferon-omega (IFNW1) DMDZWPL MT DTT DMDZWPL MA Modulator DMDZWPL RN Interferons and viral infections. Biofactors. 2009 Jan-Feb;35(1):14-20. DMDZWPL RU https://pubmed.ncbi.nlm.nih.gov/19319841 DM5UFRO DI DM5UFRO DM5UFRO DN Itriglumide DM5UFRO MI TTVFO0U DM5UFRO MN Gastrin/cholecystokinin type B receptor (CCKBR) DM5UFRO MT DTT DM5UFRO MA Antagonist DM5UFRO RN Role of CCK/gastrin receptors in gastrointestinal/metabolic diseases and results of human studies using gastrin/CCK receptor agonists/antagonists in these diseases. Curr Top Med Chem. 2007; 7(12): 1211-1231. DM5UFRO RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2718729/ DMCJX79 DI DMCJX79 DMCJX79 DN ITV-1 DMCJX79 MI TTG90S6 DMCJX79 MN Human immunodeficiency virus Glycoprotein 41 (HIV gp41) DMCJX79 MT DTT DMCJX79 RN Clinical pipeline report, company report or official report of Immunotech Laboratories. DMCJX79 RU http://www.immunotechlab.com/ipf/ DMJV3AX DI DMJV3AX DMJV3AX DN IVA337 DMJV3AX MI TTRMIZ7 DMJV3AX MN Peroxisome proliferator-activated receptor (PPAR) DMJV3AX MT DTT DMJV3AX MA Agonist DMJV3AX RN Pan-PPAR agonist IVA337 is effective in experimental lung fibrosis and pulmonary hypertension. Ann Rheum Dis. 2017 Nov;76(11):1931-1940. DMJV3AX RU https://pubmed.ncbi.nlm.nih.gov/28801346 DM0OYLQ DI DM0OYLQ DM0OYLQ DN I-vation DM0OYLQ MI TTJL8VG DM0OYLQ MN Corticosteroid-binding globulin (SERPINA6) DM0OYLQ MT DTT DM0OYLQ MA Modulator DM0OYLQ RN Cortisol binding in rat skeletal muscle. J Biol Chem. 1975 Feb 25;250(4):1207-11. DM0OYLQ RU https://pubmed.ncbi.nlm.nih.gov/163248 DM457XO DI DM457XO DM457XO DN IW-1701 DM457XO MI TT6HPVC DM457XO MN Guanylate cyclase (GC) DM457XO MT DTT DM457XO MA Stimulator DM457XO RN Clinical pipeline report, company report or official report of Cyclerion Therapeutics. DM457XO RU https://www.cyclerion.com/other-clinical-assets/ DMK2T7J DI DMK2T7J DMK2T7J DN IW-1973 DMK2T7J MI TT23PYC DMK2T7J MN Soluble guanylate cyclase (GCS) DMK2T7J MT DTT DMK2T7J MA Agonist DMK2T7J RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMK2T7J RU http://phrma-docs.phrma.org/files/dmfile/2018_Heart-Disease-and-Stroke_MID-Drug-List.pdf DMP42W1 DI DMP42W1 DMP42W1 DN IW-6118 DMP42W1 MI TTDP1UC DMP42W1 MN Fatty acid amide hydrolase (FAAH) DMP42W1 MT DTT DMP42W1 MA Modulator DMP42W1 RN The Discovery and Development of Inhibitors of Fatty Acid Amide Hydrolase (FAAH). Bioorg Med Chem Lett. 2011 August 15; 21(16): 4674-4685. DMP42W1 RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3146581/ DM3WSDR DI DM3WSDR DM3WSDR DN IXT-m200 DM3WSDR MI TT3UEY0 DM3WSDR MN Methamphetamine (Meth) DM3WSDR MT DTT DM3WSDR MA Antagonist DM3WSDR RN Clinical pipeline report, company report or official report of InterveXion Therapeutics. DM3WSDR RU http://intervexion.com/research-development/anti-methamphetamine-products/ DM9XKJU DI DM9XKJU DM9XKJU DN J 591 Lu-177 DM9XKJU MI TT9G4N0 DM9XKJU MN Glutamate carboxypeptidase II (GCPII) DM9XKJU MT DTT DM9XKJU MA Modulator DM9XKJU RN Phase II study of Lutetium-177-labeled anti-prostate-specific membrane antigen monoclonal antibody J591 for metastatic castration-resistant prostate cancer. Clin Cancer Res. 2013 Sep 15;19(18):5182-91. DM9XKJU RU https://pubmed.ncbi.nlm.nih.gov/23714732 DMKU6MW DI DMKU6MW DMKU6MW DN JB991 DMKU6MW MI TT9B4N3 DMKU6MW MN Prostaglandin receptor (PTGR) DMKU6MW MT DTT DMKU6MW MA Agonist DMKU6MW RN US patent application no. 2006,0041,016, Composition and method for the treatment of psoriasis. DMKU6MW RU http://www.google.com/patents/US20060041016 DM89ASO DI DM89ASO DM89ASO DN JCAR015 DM89ASO MI TTW640A DM89ASO MN B-lymphocyte surface antigen B4 (CD19) DM89ASO MT DTT DM89ASO MA CAR-T-Cell-Therapy DM89ASO RN ClinicalTrials.gov (NCT02535364) Study Evaluating the Efficacy and Safety of JCAR015 in Adult B-cell Acute Lymphoblastic Leukemia (B-ALL). DM89ASO RU https://clinicaltrials.gov/ct2/show/NCT02535364 DMM02VJ DI DMM02VJ DMM02VJ DN JI-101 DMM02VJ MI TT0JESD DMM02VJ MN Erbb4 tyrosine kinase receptor (Erbb-4) DMM02VJ MT DTT DMM02VJ MA Modulator DMM02VJ RN A pilot study of JI-101, an inhibitor of VEGFR-2, PDGFR-, and EphB4 receptors, in combination with everolimus and as a single agent in an ovarian cancer expansion cohort.Invest New Drugs.2015 Dec;33(6):1217-24. DMM02VJ RU https://www.ncbi.nlm.nih.gov/pubmed/26365907 DMARQ0H DI DMARQ0H DMARQ0H DN JKB-122 DMARQ0H MI TTN4QDT DMARQ0H MN Opioid receptor (OPR) DMARQ0H MT DTT DMARQ0H MA Modulator DMARQ0H RN WO patent application no. 2011,1401,90, Tetrazolones as inhibitors of fatty acid synthase. DMARQ0H RU http://worldwide.espacenet.com/publicationDetails/biblio?DB=worldwide.espacenet.com&II=0&ND=3&adjacent=true&locale=en_EP&FT=D&date=20111110&CC=WO&NR=2011140190A1&KC=A1 DMJSVRL DI DMJSVRL DMJSVRL DN JM216 DMJSVRL MI TTUTN1I DMJSVRL MN Human Deoxyribonucleic acid (hDNA) DMJSVRL MT DTT DMJSVRL MA Modulator DMJSVRL RN Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41. DMJSVRL RU https://www.ncbi.nlm.nih.gov/pubmed/15950434 DMBXWJ5 DI DMBXWJ5 DMBXWJ5 DN JNJ 63723283 DMBXWJ5 MI TTNBFWK DMBXWJ5 MN Programmed cell death protein 1 (PD-1) DMBXWJ5 MT DTT DMBXWJ5 RN Development of Inhibitors of the Programmed Cell Death-1/Programmed Cell Death-Ligand 1 Signaling Pathway.J Med Chem. 2019 Feb 28;62(4):1715-1730. DMBXWJ5 RU https://pubmed.ncbi.nlm.nih.gov/30247903 DMY7Q3I DI DMY7Q3I DMY7Q3I DN JNJ-10229570 DMY7Q3I MI TT6QAJ3 DMY7Q3I MN Melanocortin receptor 5 (MC5R) DMY7Q3I MT DTT DMY7Q3I MA Antagonist DMY7Q3I RN A melanocortin receptor 1 and 5 antagonist inhibits sebaceous gland differentiation and the production of sebum-specific lipids. J Dermatol Sci. 2011 Jul;63(1):23-32. DMY7Q3I RU https://pubmed.ncbi.nlm.nih.gov/21602033 DM7OTQS DI DM7OTQS DM7OTQS DN JNJ-10311795 DM7OTQS MI TTQAJF1 DM7OTQS MN Cathepsin G (CTSG) DM7OTQS MT DTT DM7OTQS MA Inhibitor DM7OTQS RN Discovery of potent, selective, orally active, nonpeptide inhibitors of human mast cell chymase. J Med Chem. 2007 Apr 19;50(8):1727-30. DM7OTQS RU https://pubmed.ncbi.nlm.nih.gov/17361995 DM7OTQS DI DM7OTQS DM7OTQS DN JNJ-10311795 DM7OTQS MI TT8VUE0 DM7OTQS MN Chymase (CYM) DM7OTQS MT DTT DM7OTQS MA Inhibitor DM7OTQS RN Discovery of potent, selective, orally active, nonpeptide inhibitors of human mast cell chymase. J Med Chem. 2007 Apr 19;50(8):1727-30. DM7OTQS RU https://pubmed.ncbi.nlm.nih.gov/17361995 DMPFG7H DI DMPFG7H DMPFG7H DN JNJ-16269110 DMPFG7H MI TTUS1RD DMPFG7H MN Microsomal triglyceride transfer protein (MTTP) DMPFG7H MT DTT DMPFG7H MA Inhibitor DMPFG7H RN ClinicalTrials.gov (NCT00672386) A Study of the Safety and Effectiveness of a R256918 in Patients With Type 2 Diabetes. U.S. National Institutes of Health. DMPFG7H RU https://clinicaltrials.gov/ct2/show/NCT00672386 DM1GRCU DI DM1GRCU DM1GRCU DN JNJ-17216498 DM1GRCU MI TT9JNIC DM1GRCU MN Histamine H3 receptor (H3R) DM1GRCU MT DTT DM1GRCU MA Antagonist DM1GRCU RN Acute wake-promoting actions of JNJ-5207852, a novel, diamine-based H3 antagonist. Br J Pharmacol. 2004 Nov;143(5):649-61. DM1GRCU RU https://pubmed.ncbi.nlm.nih.gov/15466448 DMV1T59 DI DMV1T59 DMV1T59 DN JNJ-18038683 DMV1T59 MI TTO9X1H DMV1T59 MN 5-HT 7 receptor (HTR7) DMV1T59 MT DTT DMV1T59 MA Antagonist DMV1T59 RN Selective pharmacological blockade of the 5-HT7 receptor attenuates light and 8-OH-DPAT induced phase shifts of mouse circadian wheel running activity. Front Behav Neurosci. 2015 Jan 15;8:453. DMV1T59 RU https://pubmed.ncbi.nlm.nih.gov/25642174 DMKIE9C DI DMKIE9C DMKIE9C DN JNJ-26481585 DMKIE9C MI TTBH0VX DMKIE9C MN Histone deacetylase (HDAC) DMKIE9C MT DTT DMKIE9C MA Modulator DMKIE9C RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7503). DMKIE9C RU http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=7503 DMQD1GN DI DMQD1GN DMQD1GN DN JNJ-32729463 DMQD1GN MI TTN6J5F DMQD1GN MN Bacterial DNA gyrase (Bact gyrase) DMQD1GN MT DTT DMQD1GN MA Inhibitor DMQD1GN RN Antistaphylococcal activities of the new fluoroquinolone JNJ-Q2. Antimicrob Agents Chemother. 2011 Dec;55(12):5512-21. DMQD1GN RU https://pubmed.ncbi.nlm.nih.gov/21911562 DMQD1GN DI DMQD1GN DMQD1GN DN JNJ-32729463 DMQD1GN MI TTFK8YB DMQD1GN MN Bacterial DNA topoisomerase 4A (Bact parC) DMQD1GN MT DTT DMQD1GN MA Inhibitor DMQD1GN RN Antistaphylococcal activities of the new fluoroquinolone JNJ-Q2. Antimicrob Agents Chemother. 2011 Dec;55(12):5512-21. DMQD1GN RU https://pubmed.ncbi.nlm.nih.gov/21911562 DMV41P5 DI DMV41P5 DMV41P5 DN JNJ-37822681 DMV41P5 MI DE4LYSA DMV41P5 MN Cytochrome P450 3A4 (CYP3A4) DMV41P5 MT DME DMV41P5 MA Metabolism DMV41P5 RN CYP3A4 and 3A5 catalysed alprazolam metabolism in vitro and in vivo. International Clinical Psychopharmacology, 2006, 21(4):A33. DMV41P5 RU https://www.researchgate.net/figure/Cloning-and-expression-CYP3A43-and-CYP3A4-and-metabolism-of-alprazolam-in-vitro-by_fig13_5310993 DMV41P5 DI DMV41P5 DMV41P5 DN JNJ-37822681 DMV41P5 MI TTEX248 DMV41P5 MN Dopamine D2 receptor (D2R) DMV41P5 MT DTT DMV41P5 MA Agonist DMV41P5 RN Population pharmacokinetics of JNJ-37822681, a selective fast-dissociating dopamine D receptor antagonist, in healthy subjects and subjects with schizophrenia and dose selection based on simulated D receptor occupancy. Clin Pharmacokinet. 2013 Nov;52(11):1005-15. DMV41P5 RU https://pubmed.ncbi.nlm.nih.gov/23754735 DM9UMIO DI DM9UMIO DM9UMIO DN JNJ-38518168 DM9UMIO MI TTXJ178 DM9UMIO MN Histamine H4 receptor (H4R) DM9UMIO MT DTT DM9UMIO MA Antagonist DM9UMIO RN The histamine H4 receptor: from orphan to the clinic. Front Pharmacol. 2015; 6: 65. DM9UMIO RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4379874/ DM0WY3H DI DM0WY3H DM0WY3H DN JNJ-39220675 DM0WY3H MI TT9JNIC DM0WY3H MN Histamine H3 receptor (H3R) DM0WY3H MT DTT DM0WY3H MA Antagonist DM0WY3H RN JNJ-39220675, a novel selective histamine H3 receptor antagonist, reduces the abuse-related effects of alcohol in rats. Psychopharmacology (Berl). 2011 Apr;214(4):829-41. DM0WY3H RU https://pubmed.ncbi.nlm.nih.gov/21086115 DMUOEKM DI DMUOEKM DMUOEKM DN JNJ-39393406 DMUOEKM MI TTLA931 DMUOEKM MN Neuronal acetylcholine receptor alpha-7 (CHRNA7) DMUOEKM MT DTT DMUOEKM MA Modulator DMUOEKM RN Allosteric alpha-7 nicotinic receptor modulation and P50 sensory gating in schizophrenia: a proof-of-mechanism study. Neuropharmacology. 2013 Jan;64:197-204. DMUOEKM RU https://pubmed.ncbi.nlm.nih.gov/22766391 DM219SF DI DM219SF DM219SF DN JNJ-40346527 DM219SF MI TT731LW DM219SF MN Colony stimulating factor-1 receptor (CSF-1R) DM219SF MT DTT DM219SF MA Modulator DM219SF RN An Open-Label, Multicenter, Phase I/II Study of JNJ-40346527, a CSF-1R Inhibitor, in Patients with Relapsed or Refractory Hodgkin Lymphoma. Clin Cancer Res. 2015 Apr 15;21(8):1843-50. DM219SF RU https://pubmed.ncbi.nlm.nih.gov/25628399 DM72GZO DI DM72GZO DM72GZO DN JNJ-42165279 DM72GZO MI TTDP1UC DM72GZO MN Fatty acid amide hydrolase (FAAH) DM72GZO MT DTT DM72GZO MA Inhibitor DM72GZO RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DM72GZO RU http://phrma-docs.phrma.org/files/dmfile/MID_Mental-Illness-2017-Drug-List_Final.pdf DMJ1FXL DI DMJ1FXL DMJ1FXL DN JNJ-53718678 DMJ1FXL MI TT57ID8 DMJ1FXL MN Respiratory syncytial virus protein F (RSV F) DMJ1FXL MT DTT DMJ1FXL MA Inhibitor DMJ1FXL RN Antiviral Activity of Oral JNJ-53718678 in Healthy Adult Volunteers Challenged With Respiratory Syncytial Virus: A Placebo-Controlled Study. J Infect Dis. 2018 Jul 24;218(5):748-756. DMJ1FXL RU https://pubmed.ncbi.nlm.nih.gov/29684148 DM9RW6H DI DM9RW6H DM9RW6H DN JNJ-56136379 DM9RW6H MI TTM42UJ DM9RW6H MN Hepatitis B virus Capsid protein (HBV C) DM9RW6H MT DTT DM9RW6H MA Inhibitor DM9RW6H RN JNJ-56136379, an HBV Capsid Assembly Modulator, Is Well-Tolerated and Has Antiviral Activity in a Phase 1 Study of Patients With Chronic Infection. Gastroenterology. 2020 Aug;159(2):521-533.e9. DM9RW6H RU https://pubmed.ncbi.nlm.nih.gov/32343960 DME2S4D DI DME2S4D DME2S4D DN JNJ-61393215 DME2S4D MI TT60Q8D DME2S4D MN Orexin receptor type 1 (HCRTR1) DME2S4D MT DTT DME2S4D MA Antagonist DME2S4D RN Translational evaluation of novel selective orexin-1 receptor antagonist JNJ-61393215 in an experimental model for panic in rodents and humans. Transl Psychiatry. 2020 Sep 7;10(1):308. DME2S4D RU https://pubmed.ncbi.nlm.nih.gov/32895369 DMVSUH1 DI DMVSUH1 DMVSUH1 DN JNJ-64565111 DMVSUH1 MI TT0NUFM DMVSUH1 MN Glucagon (GCG) DMVSUH1 MT DTT DMVSUH1 MA Agonist DMVSUH1 RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMVSUH1 RU http://phrma-docs.phrma.org/files/dmfile/mid-diabetes-drug-list.pdf DM3ICO6 DI DM3ICO6 DM3ICO6 DN JNJ-74494550 DM3ICO6 MI TTNCIE0 DM3ICO6 MN CD70 antigen (CD27-L) DM3ICO6 MT DTT DM3ICO6 RN Targeting CD70 with cusatuzumab eliminates acute myeloid leukemia stem cells in patients treated with hypomethylating agents. Nat Med. 2020 Sep;26(9):1459-1467. DM3ICO6 RU https://pubmed.ncbi.nlm.nih.gov/32601337 DMXTKCR DI DMXTKCR DMXTKCR DN JT02 DMXTKCR MI TTQOVYA DMXTKCR MN C-X-C motif chemokine 10 (CXCL10) DMXTKCR MT DTT DMXTKCR MA Inhibitor DMXTKCR RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMXTKCR RU http://phrma-docs.phrma.org/files/dmfile/medicines-in-development-drug-list-autoimmune-diseases.pdf DM2LBHN DI DM2LBHN DM2LBHN DN JTE-051 DM2LBHN MI TT3C80U DM2LBHN MN T-cell-specific kinase (ITK) DM2LBHN MT DTT DM2LBHN MA Inhibitor DM2LBHN RN Characterisation of a K390R ITK Kinase Dead Transgenic Mouse - Implications for ITK as a Therapeutic Target. PLoS One. 2014; 9(9): e107490. DM2LBHN RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4174519/ DM1945H DI DM1945H DM1945H DN JTT-251 DM1945H MI TT3UNDH DM1945H MN Pyruvate dehydrogenase kinase (PDHK) DM1945H MT DTT DM1945H MA Inhibitor DM1945H RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DM1945H RU http://phrma-docs.phrma.org/files/dmfile/mid-diabetes-drug-list.pdf DMGLVBI DI DMGLVBI DMGLVBI DN JTT-302 DMGLVBI MI TTFQAYR DMGLVBI MN Cholesteryl ester transfer protein (CETP) DMGLVBI MT DTT DMGLVBI MA Inhibitor DMGLVBI RN The dyslipidaemia market. Nat Rev Drug Discov. 2014 Nov;13(11):807-8. DMGLVBI RU https://pubmed.ncbi.nlm.nih.gov/25323928 DM50M2R DI DM50M2R DM50M2R DN JTT-654 DM50M2R MI TTN7BL9 DM50M2R MN Corticosteroid 11-beta-dehydrogenase 1 (HSD11B1) DM50M2R MT DTT DM50M2R MA Inhibitor DM50M2R RN New Therapeutic Strategies for Type 2 Diabetes: Small Molecule Approaches. 2012. Chapter 5. Page(131). DM50M2R RU https://books.google.com.hk/books?id=0rmlVGhlJ0IC&pg=PA131&lpg=PA131&dq=RG-7234++New+Therapeutic+Strategies+for+Type+2+Diabetes&source=bl&ots=toqK7w4uiI&sig=sx5iyfQWH2bTCSZmT5aUQiKfPuM&hl=zh-CN&sa=X&ved=0CB0Q6AEwAGoVChMIsZ_k6dDGyAIViLeOCh0oUQpr#v=onepage&q=RG-7234%20%20New%20Therapeutic%20Strategies%20for%20Type%202%20Diabetes&f=false DMED5J6 DI DMED5J6 DMED5J6 DN JTT-851 DMED5J6 MI TTB8FUC DMED5J6 MN Free fatty acid receptor 1 (GPR40) DMED5J6 MT DTT DMED5J6 MA Agonist DMED5J6 RN Treatment of Type 2 Diabetes by Free Fatty Acid Receptor Agonists. Front Endocrinol (Lausanne) 2014; 5: 137. DMED5J6 RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4147718/ DMGXTOP DI DMGXTOP DMGXTOP DN JTX-2011 DMGXTOP MI TTE5VP6 DMGXTOP MN Inducible T-cell costimulator (ICOS) DMGXTOP MT DTT DMGXTOP MA Agonist DMGXTOP RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMGXTOP RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DMOT0M7 DI DMOT0M7 DMOT0M7 DN JTX-4014 DMOT0M7 MI TTNBFWK DMOT0M7 MN Programmed cell death protein 1 (PD-1) DMOT0M7 MT DTT DMOT0M7 MA Inhibitor DMOT0M7 RN Clinical pipeline report, company report or official report of Jounce Therapeutics. DMOT0M7 RU https://jouncetx.com/our-pipeline/ DMZKYNO DI DMZKYNO DMZKYNO DN Juvidex DMZKYNO MI TTPNE41 DMZKYNO MN CI Man-6-P receptor (IGF2R) DMZKYNO MT DTT DMZKYNO MA Modulator DMZKYNO RN Hypertrophic Scarring and Keloids: Pathomechanisms and Current and Emerging Treatment Strategies. Mol Med. 2011 Jan-Feb; 17(1-2): 113-125. DMZKYNO RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3022978/ DMPMU38 DI DMPMU38 DMPMU38 DN JVRS-100 DMPMU38 MI TTSHG0T DMPMU38 MN Toll-like receptor 9 (TLR9) DMPMU38 MT DTT DMPMU38 RN Cationic lipid/DNA complexes (JVRS-100) combined with influenza vaccine (Fluzone ) increases antibody response, cellular immunity, and antigenically drifted protection. Vaccine. 2009 June 12; 27(29):3811-3820. DMPMU38 RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2690618/ DMD4OK0 DI DMD4OK0 DMD4OK0 DN K-134 DMD4OK0 MI TTZCG4L DMD4OK0 MN Phosphodiesterase 3 (PDE3) DMD4OK0 MT DTT DMD4OK0 MA Modulator DMD4OK0 RN A phase II dose-ranging study of the phosphodiesterase inhibitor K-134 in patients with peripheral artery disease and claudication. J Vasc Surg. 2012 Feb;55(2):381-389.e1. DMD4OK0 RU https://pubmed.ncbi.nlm.nih.gov/22119244 DMZCVD7 DI DMZCVD7 DMZCVD7 DN K-201 DMZCVD7 MI TT1VOHK DMZCVD7 MN Potassium channel unspecific (KC) DMZCVD7 MT DTT DMZCVD7 MA Modulator DMZCVD7 RN Cardiac ryanodine receptor in metabolic syndrome: is JTV519 (K201) future therapy DMZCVD7 RU https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3340112 DMQVN6P DI DMQVN6P DMQVN6P DN K-604 DMQVN6P MI TTMF541 DMQVN6P MN Liver carboxylesterase (CES1) DMQVN6P MT DTT DMQVN6P MA Inhibitor DMQVN6P RN A selective ACAT-1 inhibitor, K-604, suppresses fatty streak lesions in fat-fed hamsters without affecting plasma cholesterol levels. Atherosclerosis. 2007 Apr;191(2):290-7. DMQVN6P RU https://pubmed.ncbi.nlm.nih.gov/16820149 DMJLNZQ DI DMJLNZQ DMJLNZQ DN K-828-AB DMJLNZQ MI TTT2LD9 DMJLNZQ MN GABA transaminase (ABAT) DMJLNZQ MT DTT DMJLNZQ MA Inhibitor DMJLNZQ RN Phase II clinical trial of K-828-AB for treating behavioral and psychological symptoms of dementia. Kowa Co. Ltd. DMJLNZQ RU http://www.biocentury.com/products/k-828-ab DMMSTCF DI DMMSTCF DMMSTCF DN K-832 DMMSTCF MI TTSD92E DMMSTCF MN Interleukin-1 (IL1) DMMSTCF MT DTT DMMSTCF MA Inhibitor DMMSTCF RN Emerging drugs for rheumatoid arthritis. Expert Opin Emerg Drugs. 2008 Mar;13(1):175-96. DMMSTCF RU https://pubmed.ncbi.nlm.nih.gov/18321156 DMTMCPZ DI DMTMCPZ DMTMCPZ DN KB001A DMTMCPZ MI TTLK9NJ DMTMCPZ MN Pseudomonas PcrV protein type III (Pseudo pcrV) DMTMCPZ MT DTT DMTMCPZ MA Inhibitor DMTMCPZ RN KB001-A, a novel anti-inflammatory, found to be safe and well-tolerated in cystic fibrosis patients infected with Pseudomonas aeruginosa. J Cyst Fibros. 2018 Jul;17(4):484-491. DMTMCPZ RU https://pubmed.ncbi.nlm.nih.gov/29292092 DM60G5O DI DM60G5O DM60G5O DN KB002/003 DM60G5O MI TTNYZG2 DM60G5O MN Granulocyte-macrophage colony-stimulating factor (CSF2) DM60G5O MT DTT DM60G5O MA Modulator DM60G5O RN Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41. DM60G5O RU https://www.ncbi.nlm.nih.gov/pubmed/15950434 DM74KIM DI DM74KIM DM74KIM DN KB-003 DM74KIM MI TTNYZG2 DM74KIM MN Granulocyte-macrophage colony-stimulating factor (CSF2) DM74KIM MT DTT DM74KIM RN US patent application no. 2010,0158,905, Combination therapy of arthritis with tranilast. DM74KIM RU https://www.google.com/patents/US20100158905 DMZ4MCG DI DMZ4MCG DMZ4MCG DN KB-6806 DMZ4MCG MI TTNXLKE DMZ4MCG MN 5-HT 3 receptor (5HT3R) DMZ4MCG MT DTT DMZ4MCG MA Antagonist DMZ4MCG RN Emerging drugs for chemotherapy-induced emesis. Expert Opin Emerg Drugs. 2006 Mar;11(1):137-51. DMZ4MCG RU https://pubmed.ncbi.nlm.nih.gov/16503832 DMEFW3G DI DMEFW3G DMEFW3G DN KD019 DMEFW3G MI TTI4ZX2 DMEFW3G MN Ephrin type-B receptor 4 (EPHB4) DMEFW3G MT DTT DMEFW3G MA Modulator DMEFW3G RN XL647--a multitargeted tyrosine kinase inhibitor: results of a phase II study in subjects with non-small cell lung cancer who have progressed after responding to treatment with either gefitinib or erlotinib. J Thorac Oncol. 2012 Jan;7(1):219-26. DMEFW3G RU https://pubmed.ncbi.nlm.nih.gov/22011666 DMEFW3G DI DMEFW3G DMEFW3G DN KD019 DMEFW3G MI TTJSQEF DMEFW3G MN Tyrosine-protein kinase (PTK) DMEFW3G MT DTT DMEFW3G MA Inhibitor DMEFW3G RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMEFW3G RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DM548TK DI DM548TK DM548TK DN KD025 DM548TK MI TTGWKQJ DM548TK MN Rho-associated protein kinase 2 (ROCK2) DM548TK MT DTT DM548TK MA Inhibitor DM548TK RN Selective oral ROCK2 inhibitor down-regulates IL-21 and IL-17 secretion in human T cells via STAT3-dependent mechanism. Proc Natl Acad Sci U S A. 2014 Nov 25;111(47):16814-9. DM548TK RU https://pubmed.ncbi.nlm.nih.gov/25385601 DME1WV2 DI DME1WV2 DME1WV2 DN KD-7040 DME1WV2 MI TTF10I9 DME1WV2 MN Nitric-oxide synthase inducible (NOS2) DME1WV2 MT DTT DME1WV2 MA Inhibitor DME1WV2 RN WO patent application no. 2014,0214,08, Method for treating cancer by anticancer agent co-administration. DME1WV2 RU http://worldwide.espacenet.com/publicationDetails/biblio?DB=worldwide.espacenet.com&II=0&ND=3&adjacent=true&locale=en_EP&FT=D&date=20140206&CC=WO&NR=2014021408A1&KC=A1 DMFO6MH DI DMFO6MH DMFO6MH DN Kevetrin DMFO6MH MI TT7SBF5 DMFO6MH MN Cellular tumor antigen p53 (TP53) DMFO6MH MT DTT DMFO6MH MA Stimulator DMFO6MH RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMFO6MH RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DMF6CTI DI DMF6CTI DMF6CTI DN KHK-6188 DMF6CTI MI TTMSFAW DMF6CTI MN Cannabinoid receptor 2 (CB2) DMF6CTI MT DTT DMF6CTI MA Agonist DMF6CTI RN Recent Development of CB2 Selective and Peripheral CB1/CB2 Cannabinoid Receptor Ligands. Current Medicinal Chemistry . 10/2013; 21(2). DMF6CTI RU http://www.researchgate.net/publication/258114758_Recent_Development_of_CB2_Selective_and_Peripheral_CB1CB2_Cannabinoid_Receptor_Ligands DM40HOY DI DM40HOY DM40HOY DN KLH-2109 DM40HOY MI TT8R70G DM40HOY MN Gonadotropin-releasing hormone receptor (GNRHR) DM40HOY MT DTT DM40HOY MA Agonist DM40HOY RN Clinical pipeline report, company report or official report of Avarx. DM40HOY RU http://www.avarx.com/AvaRx/SubDomains/bucket2705902527756613996/Listings/bucket5664821816690947691/Public.Listing.display.html DM05TBE DI DM05TBE DM05TBE DN KLS-0611 DM05TBE MI TTHBUXE DM05TBE MN Mucin (MUC) DM05TBE MT DTT DM05TBE MA Stimulator DM05TBE RN WO patent application no. 2011,1034,23, Cyclobutane and methylcyclobutane derivatives as janus kinase inhibitors. DM05TBE RU http://worldwide.espacenet.com/publicationDetails/biblio?DB=worldwide.espacenet.com&II=0&ND=3&adjacent=true&locale=en_EP&FT=D&date=20110825&CC=WO&NR=2011103423A1&KC=A1 DMNLH9W DI DMNLH9W DMNLH9W DN KN026 DMNLH9W MI TT6EO5L DMNLH9W MN Erbb2 tyrosine kinase receptor (HER2) DMNLH9W MT DTT DMNLH9W MA Inhibitor DMNLH9W RN Clinical pipeline report, company report or official report of Alphamab Oncology. DMNLH9W RU http://www.alphamabonc.com/pipeline/kn026.html DMKLMG6 DI DMKLMG6 DMKLMG6 DN KN035 DMKLMG6 MI TT8ZLTI DMKLMG6 MN Programmed cell death 1 ligand 1 (PD-L1) DMKLMG6 MT DTT DMKLMG6 RN Development of Inhibitors of the Programmed Cell Death-1/Programmed Cell Death-Ligand 1 Signaling Pathway.J Med Chem. 2019 Feb 28;62(4):1715-1730. DMKLMG6 RU https://pubmed.ncbi.nlm.nih.gov/30247903 DMQZ5HF DI DMQZ5HF DMQZ5HF DN KNI-272 DMQZ5HF MI DE4LYSA DMQZ5HF MN Cytochrome P450 3A4 (CYP3A4) DMQZ5HF MT DME DMQZ5HF MA Metabolism DMQZ5HF RN Metabolic characterization of a tripeptide human immunodeficiency virus type 1 protease inhibitor, KNI-272, in rat liver microsomes. Antimicrob Agents Chemother. 1999 Mar;43(3):549-56. DMQZ5HF RU https://www.ncbi.nlm.nih.gov/pubmed/?term=10049266 DMQZ5HF DI DMQZ5HF DMQZ5HF DN KNI-272 DMQZ5HF MI TT5FNQT DMQZ5HF MN Human immunodeficiency virus Protease (HIV PR) DMQZ5HF MT DTT DMQZ5HF MA Modulator DMQZ5HF RN Oxidative modifications of kynostatin-272, a potent human immunodeficiency virus type 1 protease inhibitor: potential mechanism for altered activit... Antimicrob Agents Chemother. 2002 Feb;46(2):402-8. DMQZ5HF RU https://www.ncbi.nlm.nih.gov/pubmed/11796349 DMCO8UZ DI DMCO8UZ DMCO8UZ DN KP-496 DMCO8UZ MI TTGKOY9 DMCO8UZ MN Leukotriene CysLT1 receptor (CYSLTR1) DMCO8UZ MT DTT DMCO8UZ MA Modulator DMCO8UZ RN Effects of KP-496, a novel dual antagonist for leukotriene D4 and thromboxane A2 receptors, on contractions induced by various agonists in the guinea pig trachea. Allergol Int. 2006 Dec;55(4):403-10. DMCO8UZ RU https://pubmed.ncbi.nlm.nih.gov/17130683 DMCO8UZ DI DMCO8UZ DMCO8UZ DN KP-496 DMCO8UZ MI TT2O84V DMCO8UZ MN Thromboxane A2 receptor (TBXA2R) DMCO8UZ MT DTT DMCO8UZ MA Modulator DMCO8UZ RN Effects of KP-496, a novel dual antagonist for leukotriene D4 and thromboxane A2 receptors, on contractions induced by various agonists in the guinea pig trachea. Allergol Int. 2006 Dec;55(4):403-10. DMCO8UZ RU https://pubmed.ncbi.nlm.nih.gov/17130683 DM4WHOS DI DM4WHOS DM4WHOS DN KPP203 DM4WHOS MI TT7BQRM DM4WHOS MN Sphingosine-1 phosphate receptor (S1PR) DM4WHOS MT DTT DM4WHOS MA Agonist DM4WHOS RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DM4WHOS RU http://phrma-docs.phrma.org/files/dmfile/medicines-in-development-drug-list-autoimmune-diseases.pdf DMQDLVW DI DMQDLVW DMQDLVW DN KRP-104 DMQDLVW MI TTDIGC1 DMQDLVW MN Dipeptidyl peptidase 4 (DPP-4) DMQDLVW MT DTT DMQDLVW MA Modulator DMQDLVW RN Clinical pipeline report, company report or official report of Activx. DMQDLVW RU http://www.activx.com/press/news_20080821.html DMOW9X2 DI DMOW9X2 DMOW9X2 DN KRP-203 DMOW9X2 MI TT9JZCK DMOW9X2 MN Sphingosine-1-phosphate receptor 1 (S1PR1) DMOW9X2 MT DTT DMOW9X2 MA Agonist DMOW9X2 RN Targeting the sphingosine-1-phosphate axis in cancer, inflammation and beyond. Nat Rev Drug Discov. 2013 Sep;12(9):688-702. DMOW9X2 RU https://pubmed.ncbi.nlm.nih.gov/23954895 DM08F12 DI DM08F12 DM08F12 DN KT6-971 DM08F12 MI TTNA5ZS DM08F12 MN Cholesterol absorption (Chole absorp) DM08F12 MT DTT DM08F12 MA Inhibitor DM08F12 RN Intestinal and Hepatic Niemann-Pick C1-Like 1. Correction in: Diabetes Metab J. 2013 December; 37(6): 486-487. DM08F12 RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3753488/ DMZL48U DI DMZL48U DMZL48U DN KUR-111 DMZL48U MI TT6F7GZ DMZL48U MN Parathyroid hormone (PTH) DMZL48U MT DTT DMZL48U MA Modulator DMZL48U RN Company report (Cytos) DMZL48U RU http://www.cytos.com/kur-111/ DM2N0Z3 DI DM2N0Z3 DM2N0Z3 DN KUR-211 DM2N0Z3 MI TTWODQF DM2N0Z3 MN Fibrin (FG) DM2N0Z3 MT DTT DM2N0Z3 MA Modulator DM2N0Z3 RN Clinical pipeline report, company report or official report of Kuros. DM2N0Z3 RU http://www.kuros.ch/cms/front_content.php?idcat=78 DMB4HCY DI DMB4HCY DMB4HCY DN KUR-212 DMB4HCY MI TTWODQF DMB4HCY MN Fibrin (FG) DMB4HCY MT DTT DMB4HCY MA Modulator DMB4HCY RN Clinical pipeline report, company report or official report of Kuros. DMB4HCY RU http://www.kuros.ch/cms/front_content.php?idcat=80 DMK4VOU DI DMK4VOU DMK4VOU DN KVD001 DMK4VOU MI TTMF8H9 DMK4VOU MN Plasma kallikrein (KLKB1) DMK4VOU MT DTT DMK4VOU MA Inhibitor DMK4VOU RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMK4VOU RU http://phrma-docs.phrma.org/files/dmfile/mid-diabetes-drug-list.pdf DM5N4OA DI DM5N4OA DM5N4OA DN KVD824 DM5N4OA MI TTMF8H9 DM5N4OA MN Plasma kallikrein (KLKB1) DM5N4OA MT DTT DM5N4OA MA Inhibitor DM5N4OA RN Clinical pipeline report, company report or official report of KalVista Pharmaceuticals. DM5N4OA RU https://www.kalvista.com/products-pipeline/kvd824-hae DMJGL72 DI DMJGL72 DMJGL72 DN KW-2478 DMJGL72 MI TT78R5H DMJGL72 MN Heat shock protein 90 alpha (HSP90A) DMJGL72 MT DTT DMJGL72 MA Modulator DMJGL72 RN Anti-tumor activity against multiple myeloma by combination of KW-2478, an Hsp90 inhibitor, with bortezomib. Blood Cancer J. 2012 Apr;2(4):e68. DMJGL72 RU https://pubmed.ncbi.nlm.nih.gov/22829970 DM15RZO DI DM15RZO DM15RZO DN KYMRIAH DM15RZO MI TTW640A DM15RZO MN B-lymphocyte surface antigen B4 (CD19) DM15RZO MT DTT DM15RZO MA CAR-T-Cell-Therapy DM15RZO RN ClinicalTrials.gov (NCT03642626) MT2017-45 :CAR-T Cell Therapy for Heme Malignancies DM15RZO RU https://clinicaltrials.gov/ct2/show/NCT03642626 DMLHPVW DI DMLHPVW DMLHPVW DN L1-79 DMLHPVW MI TTUHP71 DMLHPVW MN Tyrosine 3-monooxygenase (TH) DMLHPVW MT DTT DMLHPVW MA Inhibitor DMLHPVW RN Effect of L1-79 on Core Symptoms of Autism Spectrum Disorder: A Case Series. Clin Ther. 2019 Oct;41(10):1972-1981. DMLHPVW RU https://pubmed.ncbi.nlm.nih.gov/31492568 DMI2XP1 DI DMI2XP1 DMI2XP1 DN L19-IL-2 fusion protein DMI2XP1 MI TTF89GD DMI2XP1 MN Interleukin-2 (IL2) DMI2XP1 MT DTT DMI2XP1 RN National Cancer Institute Drug Dictionary (drug id 665656). DMI2XP1 RU http://www.cancer.gov/publications/dictionaries/cancer-drug?cdrid=665656 DMW6NMP DI DMW6NMP DMW6NMP DN L19-TNF-alpha DMW6NMP MI TTPJ921 DMW6NMP MN Fibronectin (FN1) DMW6NMP MT DTT DMW6NMP RN National Cancer Institute Drug Dictionary (drug id 686947). DMW6NMP RU http://www.cancer.gov/publications/dictionaries/cancer-drug?cdrid=686947 DMA0DSJ DI DMA0DSJ DMA0DSJ DN L-694,458 DMA0DSJ MI TTPLTSQ DMA0DSJ MN Neutrophil elastase (NE) DMA0DSJ MT DTT DMA0DSJ MA Inhibitor DMA0DSJ RN Neutrophil elastase inhibitors as treatment for COPD. Expert Opin Investig Drugs. 2002 Jul;11(7):965-80. DMA0DSJ RU https://pubmed.ncbi.nlm.nih.gov/12084007 DMB7WT1 DI DMB7WT1 DMB7WT1 DN L-697,661 DMB7WT1 MI TT84ETX DMB7WT1 MN Human immunodeficiency virus Reverse transcriptase (HIV RT) DMB7WT1 MT DTT DMB7WT1 MA Modulator DMB7WT1 RN Mechanism of resistance to U-90152S and sensitization to L-697,661 by a proline to leucine change at residue 236 of human immunodeficiency virus ty... FEBS Lett. 1995 Feb 13;359(2-3):233-8. DMB7WT1 RU https://www.ncbi.nlm.nih.gov/pubmed/7532595 DMTGR25 DI DMTGR25 DMTGR25 DN L-745,870 DMTGR25 MI TTE0A2F DMTGR25 MN Dopamine D4 receptor (D4R) DMTGR25 MT DTT DMTGR25 MA Antagonist DMTGR25 RN Dopamine D4 receptor involvement in the discriminative stimulus effects in rats of LSD, but not the phenethylamine hallucinogen DOI. Psychopharmacology (Berl). 2009 Apr;203(2):265-77. DMTGR25 RU https://pubmed.ncbi.nlm.nih.gov/18604600 DMNO5UE DI DMNO5UE DMNO5UE DN Labetuzumab I-131 DMNO5UE MI TTY6DTE DMNO5UE MN Carcinoembryonic antigen CEA (CD66e) DMNO5UE MT DTT DMNO5UE RN National Cancer Institute Drug Dictionary (drug id 692828). DMNO5UE RU http://www.cancer.gov/publications/dictionaries/cancer-drug?cdrid=692828 DM7063I DI DM7063I DM7063I DN LADIRUBICIN DM7063I MI TTUTN1I DM7063I MN Human Deoxyribonucleic acid (hDNA) DM7063I MT DTT DM7063I MA Binder DM7063I RN The power and potential of doxorubicin-DNA adducts. IUBMB Life. 2005 Feb;57(2):73-81. DM7063I RU https://pubmed.ncbi.nlm.nih.gov/16036566 DMJSY3Q DI DMJSY3Q DMJSY3Q DN Ladostigil DMJSY3Q MI TT1RS9F DMJSY3Q MN Acetylcholinesterase (AChE) DMJSY3Q MT DTT DMJSY3Q MA Inhibitor DMJSY3Q RN Ladostigil: a novel multimodal neuroprotective drug with cholinesterase and brain-selective monoamine oxidase inhibitory activities for Alzheimer's disease treatment. Curr Drug Targets. 2012 Apr;13(4):483-94. DMJSY3Q RU https://pubmed.ncbi.nlm.nih.gov/22280345 DMJSY3Q DI DMJSY3Q DMJSY3Q DN Ladostigil DMJSY3Q MI TT3WG5C DMJSY3Q MN Monoamine oxidase type A (MAO-A) DMJSY3Q MT DTT DMJSY3Q MA Inhibitor DMJSY3Q RN Ladostigil: a novel multimodal neuroprotective drug with cholinesterase and brain-selective monoamine oxidase inhibitory activities for Alzheimer's disease treatment. Curr Drug Targets. 2012 Apr;13(4):483-94. DMJSY3Q RU https://pubmed.ncbi.nlm.nih.gov/22280345 DMJSY3Q DI DMJSY3Q DMJSY3Q DN Ladostigil DMJSY3Q MI TTGP7BY DMJSY3Q MN Monoamine oxidase type B (MAO-B) DMJSY3Q MT DTT DMJSY3Q MA Inhibitor DMJSY3Q RN Ladostigil: a novel multimodal neuroprotective drug with cholinesterase and brain-selective monoamine oxidase inhibitory activities for Alzheimer's disease treatment. Curr Drug Targets. 2012 Apr;13(4):483-94. DMJSY3Q RU https://pubmed.ncbi.nlm.nih.gov/22280345 DMSIGAB DI DMSIGAB DMSIGAB DN L-alanosine DMSIGAB MI TTEWTCR DMSIGAB MN Adenine synthesis (Adeni synth) DMSIGAB MT DTT DMSIGAB MA Modulator DMSIGAB RN Circadian pharmacology of L-alanosine (SDX-102) in mice. Mol Cancer Ther. 2006 Feb;5(2):337-46. DMSIGAB RU https://pubmed.ncbi.nlm.nih.gov/16505107 DMR0N74 DI DMR0N74 DMR0N74 DN LAM-002 DMR0N74 MI TTA4M1N DMR0N74 MN Phosphatidylinositol-3-phosphate 5-kinase (PIP5K3) DMR0N74 MT DTT DMR0N74 MA Inhibitor DMR0N74 RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMR0N74 RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DM7MBV6 DI DM7MBV6 DM7MBV6 DN Lancovutide DM7MBV6 MI TTCYAXN DM7MBV6 MN Chloride channel unspecific (ClC) DM7MBV6 MT DTT DM7MBV6 MA Modulator DM7MBV6 RN Airway-rehydrating agents for the treatment of cystic fibrosis: past, present, and future. Ann Pharmacother. 2011 Jan;45(1):49-59. DM7MBV6 RU https://pubmed.ncbi.nlm.nih.gov/21156814 DM1VK96 DI DM1VK96 DM1VK96 DN LANEPITANT DM1VK96 MI TTZPO1L DM1VK96 MN Substance-P receptor (TACR1) DM1VK96 MT DTT DM1VK96 MA Antagonist DM1VK96 RN NK1 receptor antagonists as a new treatment for corneal neovascularization. Invest Ophthalmol Vis Sci. 2014 Sep 16;55(10):6783-94. DM1VK96 RU https://pubmed.ncbi.nlm.nih.gov/25228541 DMPRZX4 DI DMPRZX4 DMPRZX4 DN LAS 100977 DMPRZX4 MI TT2CJVK DMPRZX4 MN Adrenergic receptor beta-2 (ADRB2) DMPRZX4 MT DTT DMPRZX4 MA Agonist DMPRZX4 RN Pharmacological characterization of abediterol, a novel inhaled beta(2)-adrenoceptor agonist with long duration of action and a favorable safety profile in preclinical models. J Pharmacol Exp Ther. 2012 Aug;342(2):497-509. DMPRZX4 RU https://pubmed.ncbi.nlm.nih.gov/22588259 DM3WY0B DI DM3WY0B DM3WY0B DN LAS-41002 DM3WY0B MI TTYRL6O DM3WY0B MN Glucocorticoid receptor (NR3C1) DM3WY0B MT DTT DM3WY0B MA Modulator DM3WY0B RN Barrier-Restoring Therapies in Atopic Dermatitis: Current Approaches and Future Perspectives. Dermatol Res Pract. 2012; 2012: 923134. DM3WY0B RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3432345/ DMC04SR DI DMC04SR DMC04SR DN LB-100 DMC04SR MI TTRKDL6 DMC04SR MN Serine/threonine PP2A (PP2A) DMC04SR MT DTT DMC04SR MA Inhibitor DMC04SR RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMC04SR RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DMC04SR DI DMC04SR DMC04SR DN LB-100 DMC04SR MI TTHTKNY DMC04SR MN Serine/threonine PP2A-alpha (PPP2CA) DMC04SR MT DTT DMC04SR MA Inhibitor DMC04SR RN Inhibition of protein phosphatase 2A enhances cytotoxicity and accessibility of chemotherapeutic drugs to hepatocellular carcinomas. Mol Cancer Ther. 2014 Aug;13(8):2062-72. DMC04SR RU https://pubmed.ncbi.nlm.nih.gov/24867249 DM0OHX3 DI DM0OHX3 DM0OHX3 DN LB-30870 DM0OHX3 MI TT6L509 DM0OHX3 MN Coagulation factor IIa (F2) DM0OHX3 MT DTT DM0OHX3 MA Inhibitor DM0OHX3 RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015 DM0OHX3 RU https://www.accessdata.fda.gov/scripts/cder/drugsatfda/ DMQZJNA DI DMQZJNA DMQZJNA DN LCAR-B38M CAR-T Cell DMQZJNA MI TTZ3P4W DMQZJNA MN B-cell maturation protein (TNFRSF17) DMQZJNA MT DTT DMQZJNA MA CAR-T-Cell-Therapy DMQZJNA RN ClinicalTrials.gov (NCT03758417) A Study of LCAR-B38M CAR-T Cells, a Chimeric Antigen Receptor T-cell (CAR-T) Therapy Directed Against B-cell Maturation Antigen (BCMA) in Chinese Participants With Relapsed or Refractory Multiple Myeloma DMQZJNA RU https://clinicaltrials.gov/ct2/show/NCT03758417 DMY4IWC DI DMY4IWC DMY4IWC DN LCB-2183 DMY4IWC MI TT7CXIM DMY4IWC MN Histamine receptor (HR) DMY4IWC MT DTT DMY4IWC MA Modulator DMY4IWC RN LCB 2183 inhibits the inflammation associated with oxazolone-induced contact sensitivity. Int J Immunopharmacol. 1994 Aug;16(8):675-83. DMY4IWC RU https://pubmed.ncbi.nlm.nih.gov/7989136 DMTM4QA DI DMTM4QA DMTM4QA DN LCL161 DMTM4QA MI TTS74QB DMTM4QA MN Inhibitor of apoptosis protein (hIAP) DMTM4QA MT DTT DMTM4QA MA Modulator DMTM4QA RN National Cancer Institute Drug Dictionary (drug id 670651). DMTM4QA RU http://www.cancer.gov/publications/dictionaries/cancer-drug?cdrid=670651 DMM9F25 DI DMM9F25 DMM9F25 DN LDE225 DMM9F25 MI TT8J1S3 DMM9F25 MN Smoothened homolog (SMO) DMM9F25 MT DTT DMM9F25 MA Modulator DMM9F25 RN Inhibition of Hedgehog signalling by NVP-LDE225 (Erismodegib) interferes with growth and invasion of human renal cell carcinoma cells. Br J Cancer. 2014 Sep 9;111(6):1168-79. DMM9F25 RU https://pubmed.ncbi.nlm.nih.gov/25093491 DMIEZUB DI DMIEZUB DMIEZUB DN L-DOS47 DMIEZUB MI TTUTJGQ DMIEZUB MN Vascular endothelial growth factor receptor 2 (KDR) DMIEZUB MT DTT DMIEZUB RN Clinical pipeline report, company report or official report of Helix BioPharma. DMIEZUB RU https://www.helixbiopharma.com/pipeline/ DMS6E9J DI DMS6E9J DMS6E9J DN Lefitolimod DMS6E9J MI TTSHG0T DMS6E9J MN Toll-like receptor 9 (TLR9) DMS6E9J MT DTT DMS6E9J MA Agonist DMS6E9J RN Beneficial modulation of the tumor microenvironment and generation of anti-tumor responses by TLR9 agonist lefitolimod alone and in combination with checkpoint inhibitors. Oncoimmunology. 2019 Sep 20;8(12):e1659096. DMS6E9J RU https://pubmed.ncbi.nlm.nih.gov/31741757 DMV2YDK DI DMV2YDK DMV2YDK DN LEISH-F1 DMV2YDK MI TT3J5ZI DMV2YDK MN Cell mediated immunity response (CMIR) DMV2YDK MT DTT DMV2YDK RN A clinical trial to evaluate the safety and immunogenicity of the LEISH-F1+MPL-SE vaccine for use in the prevention of visceral leishmaniasis. Vaccine. 2011 Apr 27;29(19):3531-7. DMV2YDK RU https://pubmed.ncbi.nlm.nih.gov/21414377 DMZKBMG DI DMZKBMG DMZKBMG DN Lenapenem hydrochloride hydrate DMZKBMG MI TTJP4SM DMZKBMG MN Bacterial Penicillin binding protein (Bact PBP) DMZKBMG MT DTT DMZKBMG MA Inhibitor DMZKBMG RN Affinities of BO-2727 for bacterial penicillin-binding proteins and morphological change of gram-negative rods. J Antibiot (Tokyo). 1997 Feb;50(2):139-42. DMZKBMG RU https://pubmed.ncbi.nlm.nih.gov/9099223 DMWAD93 DI DMWAD93 DMWAD93 DN Leniolisib DMWAD93 MI TTGBPJE DMWAD93 MN PI3-kinase delta (PIK3CD) DMWAD93 MT DTT DMWAD93 MA Inhibitor DMWAD93 RN Effective "activated PI3K syndrome"-targeted therapy with the PI3K inhibitor leniolisib. Blood. 2017 Nov 23;130(21):2307-2316. DMWAD93 RU https://pubmed.ncbi.nlm.nih.gov/28972011 DMR1MQW DI DMR1MQW DMR1MQW DN Lenzilumab DMR1MQW MI TTNYZG2 DMR1MQW MN Granulocyte-macrophage colony-stimulating factor (CSF2) DMR1MQW MT DTT DMR1MQW MA Antagonist DMR1MQW RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMR1MQW RU http://phrma-docs.phrma.org/files/dmfile/MID_Immuno-Oncology-2017_Drug-List1.pdf DM7W0JE DI DM7W0JE DM7W0JE DN LEO 124249 DM7W0JE MI TTJSQEF DM7W0JE MN Tyrosine-protein kinase (PTK) DM7W0JE MT DTT DM7W0JE MA Inhibitor DM7W0JE RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DM7W0JE RU http://phrma-docs.phrma.org/files/dmfile/MID_Skin_Diseases_2018_9_FINAL.pdf DMZ6Y0T DI DMZ6Y0T DMZ6Y0T DN LEO-32731 DMZ6Y0T MI TTV5CGO DMZ6Y0T MN Phosphodiesterase 4 (PDE4) DMZ6Y0T MT DTT DMZ6Y0T MA Inhibitor DMZ6Y0T RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMZ6Y0T RU http://phrma-docs.phrma.org/files/dmfile/MID_Skin_Diseases_2018_9_FINAL.pdf DM6DL5K DI DM6DL5K DM6DL5K DN Leridistim DM6DL5K MI TTPYS82 DM6DL5K MN Interleukin 3 receptor (CSF2RB) DM6DL5K MT DTT DM6DL5K MA Agonist DM6DL5K RN Leridistim, a chimeric dual G-CSF and IL-3 receptor agonist, enhances multilineage hematopoietic recovery in a nonhuman primate model of radiation-induced myelosuppression: effect of schedule, dose, and route of administration. Stem Cells. 2001;19(6):522-33. DM6DL5K RU https://pubmed.ncbi.nlm.nih.gov/11713344 DMMQ6VT DI DMMQ6VT DMMQ6VT DN Leronlimab DMMQ6VT MI TTH91NV DMMQ6VT MN HUMAN C-C chemokine receptor 5 (CCR5) DMMQ6VT MT DTT DMMQ6VT MA Inhibitor DMMQ6VT RN Disruption of the CCL5/RANTES-CCR5 Pathway Restores Immune Homeostasis and Reduces Plasma Viral Load in Critical COVID-19 DMMQ6VT RU https://www.medrxiv.org/content/10.1101/2020.05.02.20084673v1.full.pdf DMSEVBH DI DMSEVBH DMSEVBH DN Lersivirine DMSEVBH MI DE4LYSA DMSEVBH MN Cytochrome P450 3A4 (CYP3A4) DMSEVBH MT DME DMSEVBH MA Metabolism DMSEVBH RN Excretion and metabolism of lersivirine (5-{[3,5-diethyl-1-(2-hydroxyethyl)(3,5-14C2)-1H-pyrazol-4-yl]oxy}benzene-1,3-dicarbonitrile), a next-generation non-nucleoside reverse transcriptase inhibitor, after administration of [14C]Lersivirine to healthy volunteers. Drug Metab Dispos. 2010 May;38(5):789-800. DMSEVBH RU https://www.ncbi.nlm.nih.gov/pubmed/?term=20124396 DMSEVBH DI DMSEVBH DMSEVBH DN Lersivirine DMSEVBH MI TT84ETX DMSEVBH MN Human immunodeficiency virus Reverse transcriptase (HIV RT) DMSEVBH MT DTT DMSEVBH MA Inhibitor DMSEVBH RN Safety and tolerability of lersivirine, a nonnucleoside reverse transcriptase inhibitor, during a 28-day, randomized, placebo-controlled, Phase I clinical study in healthy male volunteers. Clin Ther.2010 Oct;32(11):1889-95. DMSEVBH RU https://pubmed.ncbi.nlm.nih.gov/21095483 DMSEVBH DI DMSEVBH DMSEVBH DN Lersivirine DMSEVBH MI DEB3CV1 DMSEVBH MN UDP-glucuronosyltransferase 2B7 (UGT2B7) DMSEVBH MT DME DMSEVBH MA Metabolism DMSEVBH RN Excretion and metabolism of lersivirine (5-{[3,5-diethyl-1-(2-hydroxyethyl)(3,5-14C2)-1H-pyrazol-4-yl]oxy}benzene-1,3-dicarbonitrile), a next-generation non-nucleoside reverse transcriptase inhibitor, after administration of [14C]Lersivirine to healthy volunteers. Drug Metab Dispos. 2010 May;38(5):789-800. DMSEVBH RU https://www.ncbi.nlm.nih.gov/pubmed/?term=20124396 DMW50NF DI DMW50NF DMW50NF DN LE-SN38 DMW50NF MI DTI7UX6 DMW50NF MN Breast cancer resistance protein (ABCG2) DMW50NF MT DTP DMW50NF MA Substrate DMW50NF RN Transport of 7-ethyl-10-hydroxycamptothecin (SN-38) by breast cancer resistance protein ABCG2 in human lung cancer cells. Biochem Biophys Res Commun. 2001 Nov 9;288(4):827-32. DMW50NF RU http://www.ncbi.nlm.nih.gov/pubmed/11688982 DMW50NF DI DMW50NF DMW50NF DN LE-SN38 DMW50NF MI TTGTQHC DMW50NF MN DNA topoisomerase I (TOP1) DMW50NF MT DTT DMW50NF MA Inhibitor DMW50NF RN Analysis of type of cell death induced by topoisomerase inhibitor SN-38 in human oral squamous cell carcinoma cell lines. Anticancer Res. 2012 Nov;32(11):4823-32. DMW50NF RU https://pubmed.ncbi.nlm.nih.gov/23155248 DMW50NF DI DMW50NF DMW50NF DN LE-SN38 DMW50NF MI DTSYQGK DMW50NF MN Multidrug resistance-associated protein 1 (ABCC1) DMW50NF MT DTP DMW50NF MA Substrate DMW50NF RN ATP-Dependent efflux of CPT-11 and SN-38 by the multidrug resistance protein (MRP) and its inhibition by PAK-104P. Mol Pharmacol. 1999 May;55(5):921-8. DMW50NF RU http://molpharm.aspetjournals.org/content/55/5/921 DMW50NF DI DMW50NF DMW50NF DN LE-SN38 DMW50NF MI DTFI42L DMW50NF MN Multidrug resistance-associated protein 2 (ABCC2) DMW50NF MT DTP DMW50NF MA Substrate DMW50NF RN Biliary excretion mechanism of CPT-11 and its metabolites in humans: involvement of primary active transporters. Cancer Res. 1998 Nov 15;58(22):5137-43. DMW50NF RU http://www.ncbi.nlm.nih.gov/pubmed/9823324 DMW50NF DI DMW50NF DMW50NF DN LE-SN38 DMW50NF MI DTCSGPB DMW50NF MN Multidrug resistance-associated protein 4 (ABCC4) DMW50NF MT DTP DMW50NF MA Substrate DMW50NF RN Human intestinal transporter database: QSAR modeling and virtual profiling of drug uptake, efflux and interactions. Pharm Res. 2013 Apr;30(4):996-1007. DMW50NF RU https://doi.org/10.1007/s11095-012-0935-x DMW50NF DI DMW50NF DMW50NF DN LE-SN38 DMW50NF MI DT3D8F0 DMW50NF MN Organic anion transporting polypeptide 1B1 (SLCO1B1) DMW50NF MT DTP DMW50NF MA Substrate DMW50NF RN Organic anion transporting polypeptide 1B1: a genetically polymorphic transporter of major importance for hepatic drug uptake. Pharmacol Rev. 2011 Mar;63(1):157-81. DMW50NF RU http://www.ncbi.nlm.nih.gov/pubmed/21245207 DMW50NF DI DMW50NF DMW50NF DN LE-SN38 DMW50NF MI DT9C1TS DMW50NF MN Organic anion transporting polypeptide 1B3 (SLCO1B3) DMW50NF MT DTP DMW50NF MA Substrate DMW50NF RN Rapid screening of antineoplastic candidates for the human organic anion transporter OATP1B3 substrates using fluorescent probes. Cancer Lett. 2008 Feb 18;260(1-2):163-9. DMW50NF RU http://www.ncbi.nlm.nih.gov/pubmed/18082941 DMW50NF DI DMW50NF DMW50NF DN LE-SN38 DMW50NF MI DEYGVN4 DMW50NF MN UDP-glucuronosyltransferase 1A1 (UGT1A1) DMW50NF MT DME DMW50NF MA Metabolism DMW50NF RN Effects of green tea compounds on irinotecan metabolism. Drug Metab Dispos. 2007 Feb;35(2):228-33. DMW50NF RU https://www.ncbi.nlm.nih.gov/pubmed/?term=17108060 DMW50NF DI DMW50NF DMW50NF DN LE-SN38 DMW50NF MI DE85D2P DMW50NF MN UDP-glucuronosyltransferase 1A9 (UGT1A9) DMW50NF MT DME DMW50NF MA Metabolism DMW50NF RN Correlation between plasma concentration ratios of SN-38 glucuronide and SN-38 and neutropenia induction in patients with colorectal cancer and wild-type UGT1A1 gene. Oncol Lett. 2012 Mar;3(3):694-698. DMW50NF RU https://www.ncbi.nlm.nih.gov/pubmed/?term=22740978 DMIFGLY DI DMIFGLY DMIFGLY DN Leukemia cancer vaccine DMIFGLY MI TT6MP2Z DMIFGLY MN GMCSFR-alpha (CSF2RA) DMIFGLY MT DTT DMIFGLY RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1707). DMIFGLY RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1707 DM5LQEI DI DM5LQEI DM5LQEI DN Leuvectin DM5LQEI MI TTF89GD DM5LQEI MN Interleukin-2 (IL2) DM5LQEI MT DTT DM5LQEI MA Modulator DM5LQEI RN Intratumoral interleukin 2 for renal-cell carcinoma by direct gene transfer of a plasmid DNA/DMRIE/DOPE lipid complex. World J Urol. 2000 Apr;18(2):152-6. DM5LQEI RU https://pubmed.ncbi.nlm.nih.gov/10854152 DMOS5JZ DI DMOS5JZ DMOS5JZ DN Lexatumumab DMOS5JZ MI TTW20TU DMOS5JZ MN TRAIL receptor 2 (TRAIL-R2) DMOS5JZ MT DTT DMOS5JZ RN National Cancer Institute Drug Dictionary (drug id 528015). DMOS5JZ RU http://www.cancer.gov/publications/dictionaries/cancer-drug?cdrid=528015 DMLEX1D DI DMLEX1D DMLEX1D DN Lexibulin DMLEX1D MI TTYFKSZ DMLEX1D MN Tubulin beta (TUBB) DMLEX1D MT DTT DMLEX1D MA Inhibitor DMLEX1D RN National Cancer Institute Drug Dictionary (drug id 598799). DMLEX1D RU http://www.cancer.gov/publications/dictionaries/cancer-drug?cdrid=598799 DMZ2YBE DI DMZ2YBE DMZ2YBE DN Lexipafant DMZ2YBE MI TT84ETX DMZ2YBE MN Human immunodeficiency virus Reverse transcriptase (HIV RT) DMZ2YBE MT DTT DMZ2YBE MA Inhibitor DMZ2YBE RN Emerging antiviral drugs. Expert Opin Emerg Drugs. 2008 Sep;13(3):393-416. DMZ2YBE RU https://pubmed.ncbi.nlm.nih.gov/18764719 DMZ2YBE DI DMZ2YBE DMZ2YBE DN Lexipafant DMZ2YBE MI TTQL5VC DMZ2YBE MN Platelet-activating factor receptor (PTAFR) DMZ2YBE MT DTT DMZ2YBE MA Modulator DMZ2YBE RN Lexipafant and acute pancreatitis: a critical appraisal of the clinical trials.Eur J Surg.2002;168(4):215-9. DMZ2YBE RU https://www.ncbi.nlm.nih.gov/pubmed/12440758 DMCT1RQ DI DMCT1RQ DMCT1RQ DN LFG-316 DMCT1RQ MI TTKANGO DMCT1RQ MN Complement C5 (CO5) DMCT1RQ MT DTT DMCT1RQ RN Advances in the management of macular degeneration. F1000Prime Rep. 2014; 6: 29. DMCT1RQ RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4017905/ DM9T8A2 DI DM9T8A2 DM9T8A2 DN LGD-4665 DM9T8A2 MI TTIHYA4 DM9T8A2 MN Thrombopoietin receptor (MPL) DM9T8A2 MT DTT DM9T8A2 MA Agonist DM9T8A2 RN Emerging drugs for idiopathic thrombocytopenic purpura in adults. Expert Opin Emerg Drugs. 2008 Jun;13(2):237-54. DM9T8A2 RU https://pubmed.ncbi.nlm.nih.gov/18537519 DMPL9KG DI DMPL9KG DMPL9KG DN LGD-6972 DMPL9KG MI TT9O6WS DMPL9KG MN Glucagon receptor (GCGR) DMPL9KG MT DTT DMPL9KG MA Antagonist DMPL9KG RN Addressing Unmet Medical Needs in Type 2 Diabetes: A Narrative Review of Drugs under Development. Curr Diabetes Rev. 2015 March; 11(1): 17-31. DMPL9KG RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4428473/ DMA0RI9 DI DMA0RI9 DMA0RI9 DN LIDORESTAT DMA0RI9 MI TTFBNVI DMA0RI9 MN Aldose reductase (AKR1B1) DMA0RI9 MT DTT DMA0RI9 MA Inhibitor DMA0RI9 RN Discovery of 3-[(4,5,7-trifluorobenzothiazol-2-yl)methyl]indole-N-acetic acid (lidorestat) and congeners as highly potent and selective inhibitors ... J Med Chem. 2005 May 5;48(9):3141-52. DMA0RI9 RU https://pubmed.ncbi.nlm.nih.gov/15857120 DM32NWD DI DM32NWD DM32NWD DN LIK-066 DM32NWD MI TT2UE56 DM32NWD MN Sodium/glucose cotransporter 1 (SGLT1) DM32NWD MT DTT DM32NWD MA Inhibitor DM32NWD RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 915). DM32NWD RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=915 DM32NWD DI DM32NWD DM32NWD DN LIK-066 DM32NWD MI TTLWPVF DM32NWD MN Sodium/glucose cotransporter 2 (SGLT2) DM32NWD MT DTT DM32NWD MA Inhibitor DM32NWD RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DM32NWD RU http://phrma-docs.phrma.org/files/dmfile/2018_Heart-Disease-and-Stroke_MID-Drug-List.pdf DM9ZHRS DI DM9ZHRS DM9ZHRS DN LIM-0705 DM9ZHRS MI TTK8XD6 DM9ZHRS MN ATP-binding cassette transporter (ABCA) DM9ZHRS MT DTT DM9ZHRS MA Activator DM9ZHRS RN WO patent application no. 2010,0428,86, Pyrone analogs for therapeutic treatment. DM9ZHRS RU http://worldwide.espacenet.com/publicationDetails/biblio?DB=worldwide.espacenet.com&II=0&ND=3&adjacent=true&locale=en_EP&FT=D&date=20100415&CC=WO&NR=2010042886A2&KC=A2 DMSHGWN DI DMSHGWN DMSHGWN DN Lintopride DMSHGWN MI TTNXLKE DMSHGWN MN 5-HT 3 receptor (5HT3R) DMSHGWN MT DTT DMSHGWN MA Modulator DMSHGWN RN The effects of lintopride, a 5HT-4 antagonist, on oesophageal motility. Aliment Pharmacol Ther. 1995 Oct;9(5):563-9. DMSHGWN RU https://pubmed.ncbi.nlm.nih.gov/8580279 DMSHGWN DI DMSHGWN DMSHGWN DN Lintopride DMSHGWN MI TT07C3Y DMSHGWN MN 5-HT 4 receptor (HTR4) DMSHGWN MT DTT DMSHGWN MA Modulator DMSHGWN RN The effects of lintopride, a 5HT-4 antagonist, on oesophageal motility. Aliment Pharmacol Ther. 1995 Oct;9(5):563-9. DMSHGWN RU https://pubmed.ncbi.nlm.nih.gov/8580279 DMWY0V1 DI DMWY0V1 DMWY0V1 DN LIPO-5 DMWY0V1 MI TTFGZB6 DMWY0V1 MN Human immunodeficiency virus GAG protein (HIV gag) DMWY0V1 MT DTT DMWY0V1 RN HIV specific responses induced in nonhuman primates with ANRS HIV-Lipo-5 vaccine combined with rMVA-HIV prime or boost immunizations. Vaccine. 2015 May 11;33(20):2354-9. DMWY0V1 RU https://pubmed.ncbi.nlm.nih.gov/25839103 DMWY0V1 DI DMWY0V1 DMWY0V1 DN LIPO-5 DMWY0V1 MI TT4NXYM DMWY0V1 MN Human immunodeficiency virus Negative factor (HIV nef) DMWY0V1 MT DTT DMWY0V1 RN HIV specific responses induced in nonhuman primates with ANRS HIV-Lipo-5 vaccine combined with rMVA-HIV prime or boost immunizations. Vaccine. 2015 May 11;33(20):2354-9. DMWY0V1 RU https://pubmed.ncbi.nlm.nih.gov/25839103 DMNGT89 DI DMNGT89 DMNGT89 DN Lirilumab DMNGT89 MI TTAZF9M DMNGT89 MN RAS-like protein KIR (GEM) DMNGT89 MT DTT DMNGT89 MA Modulator DMNGT89 RN Anti-tumoral efficacy of therapeutic human anti-KIR antibody (Lirilumab/BMS-986015/IPH2102) in a preclinical xenograft tumor model. J Immunother Cancer. 2013; 1(Suppl 1): P40. DMNGT89 RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3991278/ DMD4KAU DI DMD4KAU DMD4KAU DN LIRIMILAST DMD4KAU MI TTZ97H5 DMD4KAU MN Phosphodiesterase 4A (PDE4A) DMD4KAU MT DTT DMD4KAU MA Inhibitor DMD4KAU RN Can the anti-inflammatory potential of PDE4 inhibitors be realized: guarded optimism or wishful thinking . Br J Pharmacol. 2008 October; 155(3): 288-290. DMD4KAU RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2567889/ DMD4KAU DI DMD4KAU DMD4KAU DN LIRIMILAST DMD4KAU MI TTVIAT9 DMD4KAU MN Phosphodiesterase 4B (PDE4B) DMD4KAU MT DTT DMD4KAU MA Inhibitor DMD4KAU RN Therapeutic target database update 2012: a resource for facilitating target-oriented drug discovery. Nucleic Acids Res. 2012 Jan;40(Database issue):D1128-36. DMD4KAU RU https://pubmed.ncbi.nlm.nih.gov/21948793 DMD4KAU DI DMD4KAU DMD4KAU DN LIRIMILAST DMD4KAU MI TTSKMI8 DMD4KAU MN Phosphodiesterase 4D (PDE4D) DMD4KAU MT DTT DMD4KAU MA Inhibitor DMD4KAU RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015 DMD4KAU RU https://www.accessdata.fda.gov/scripts/cder/drugsatfda/ DMVU9X1 DI DMVU9X1 DMVU9X1 DN Lisofylline DMVU9X1 MI DEJGDUW DMVU9X1 MN Cytochrome P450 1A2 (CYP1A2) DMVU9X1 MT DME DMVU9X1 MA Metabolism DMVU9X1 RN Physiologically based modeling of lisofylline pharmacokinetics following intravenous administration in mice. Eur J Drug Metab Pharmacokinet. 2016 Aug;41(4):403-12. DMVU9X1 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=25663650 DMZ3OU6 DI DMZ3OU6 DMZ3OU6 DN Lithium DMZ3OU6 MI TTRZQE3 DMZ3OU6 MN Glycogen synthase kinase-3 alpha (GSK-3A) DMZ3OU6 MT DTT DMZ3OU6 MA Inhibitor DMZ3OU6 RN The GSK3 kinase inhibitor lithium produces unexpected hyperphosphorylation of -catenin, a GSK3 substrate, in human glioblastoma cells. Biol Open. 2018 Jan 26;7(1):bio030874. DMZ3OU6 RU https://pubmed.ncbi.nlm.nih.gov/29212798 DMZ3OU6 DI DMZ3OU6 DMZ3OU6 DN Lithium DMZ3OU6 MI TTRSMW9 DMZ3OU6 MN Glycogen synthase kinase-3 beta (GSK-3B) DMZ3OU6 MT DTT DMZ3OU6 MA Inhibitor DMZ3OU6 RN The GSK3 kinase inhibitor lithium produces unexpected hyperphosphorylation of -catenin, a GSK3 substrate, in human glioblastoma cells. Biol Open. 2018 Jan 26;7(1):bio030874. DMZ3OU6 RU https://pubmed.ncbi.nlm.nih.gov/29212798 DM3XRUH DI DM3XRUH DM3XRUH DN LJN452 DM3XRUH MI TTS4UGC DM3XRUH MN Farnesoid X-activated receptor (FXR) DM3XRUH MT DTT DM3XRUH MA Agonist DM3XRUH RN FXR modulators for enterohepatic and metabolic diseases.Expert Opin Ther Pat. 2018 Nov;28(11):765-782. DM3XRUH RU https://www.ncbi.nlm.nih.gov/pubmed/30259754 DMVM13R DI DMVM13R DMVM13R DN LJPC-401 DMVM13R MI TTPCG5T DMVM13R MN Hepcidin (HAMP) DMVM13R MT DTT DMVM13R MA Agonist DMVM13R RN ClinicalTrials.gov (NCT03395704) A Study of LJPC-401 for the Treatment of Iron Overload in Adult Patients With Hereditary Hemochromatosis. U.S. National Institutes of Health. DMVM13R RU https://clinicaltrials.gov/ct2/show/NCT03395704 DMCFGP3 DI DMCFGP3 DMCFGP3 DN LKA651 DMCFGP3 MI TTQG4NR DMCFGP3 MN Erythropoietin (EPO) DMCFGP3 MT DTT DMCFGP3 RN Clinical pipeline report, company report or official report of Novartis. DMCFGP3 RU https://www.novartis.com/our-science/novartis-global-pipeline?search_api_views_fulltext=LKA651&field_pipeline_filing_date=All DMSJOE3 DI DMSJOE3 DMSJOE3 DN LM-030 DMSJOE3 MI TT5L2VC DMSJOE3 MN Kallikrein-related peptidase (KLK) DMSJOE3 MT DTT DMSJOE3 MA Inhibitor DMSJOE3 RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMSJOE3 RU http://phrma-docs.phrma.org/files/dmfile/MID_Skin_Diseases_2018_9_FINAL.pdf DMW6VA0 DI DMW6VA0 DMW6VA0 DN LM-1507.NA DMW6VA0 MI TTGKOY9 DMW6VA0 MN Leukotriene CysLT1 receptor (CYSLTR1) DMW6VA0 MT DTT DMW6VA0 MA Antagonist DMW6VA0 RN Pharmacological differences among CysLT(1) receptor antagonists with respect to LTC(4) and LTD(4) in human lung parenchyma. Biochem Pharmacol. 2002 Apr 15;63(8):1537-46. DMW6VA0 RU https://pubmed.ncbi.nlm.nih.gov/11996896 DMG7RAV DI DMG7RAV DMG7RAV DN LMB-2 DMG7RAV MI TT10Y9E DMG7RAV MN Interleukin 2 receptor alpha (IL2RA) DMG7RAV MT DTT DMG7RAV MA Modulator DMG7RAV RN Phase I trial of recombinant immunotoxin anti-Tac(Fv)-PE38 (LMB-2) in patients with hematologic malignancies. J Clin Oncol. 2000 Apr;18(8):1622-36. DMG7RAV RU https://pubmed.ncbi.nlm.nih.gov/10764422 DMQOXNL DI DMQOXNL DMQOXNL DN LMB763 DMQOXNL MI TTS4UGC DMQOXNL MN Farnesoid X-activated receptor (FXR) DMQOXNL MT DTT DMQOXNL MA Agonist DMQOXNL RN Nidufexor (LMB763), a Novel FXR Modulator for the Treatment of Nonalcoholic Steatohepatitis. J Med Chem. 2020 Apr 23;63(8):3868-3880. DMQOXNL RU https://pubmed.ncbi.nlm.nih.gov/31940200 DM01SR6 DI DM01SR6 DM01SR6 DN L-NAME DM01SR6 MI TTCM4B3 DM01SR6 MN Nitric-oxide synthase endothelial (NOS3) DM01SR6 MT DTT DM01SR6 MA Inhibitor DM01SR6 RN Counter-regulation by atorvastatin of gene modulations induced by L-NAME hypertension is associated with vascular protection. Vascul Pharmacol. 2009 Oct;51(4):253-61. DM01SR6 RU https://pubmed.ncbi.nlm.nih.gov/19586617 DMT3KB4 DI DMT3KB4 DMT3KB4 DN Lobeline DMT3KB4 MI TTNZRI3 DMT3KB4 MN Synaptic vesicle amine transporter (SLC18A2) DMT3KB4 MT DTT DMT3KB4 MA Inhibitor DMT3KB4 RN Design, synthesis and interaction at the vesicular monoamine transporter-2 of lobeline analogs: potential pharmacotherapies for the treatment of psychostimulant abuse. Curr Top Med Chem. 2011;11(9):1103-27. DMT3KB4 RU https://pubmed.ncbi.nlm.nih.gov/21050177 DMN0VS2 DI DMN0VS2 DMN0VS2 DN Lopinavir + ritonavir + ribavirin + interferon beta-1b DMN0VS2 MI TT1D53B DMN0VS2 MN COVID-19 3C-like protease (3CLpro) DMN0VS2 MT DTT DMN0VS2 MA Inhibitor DMN0VS2 RN Coronavirus puts drug repurposing on the fast track. Nat Biotechnol. 2020 Apr;38(4):379-381. DMN0VS2 RU https://pubmed.ncbi.nlm.nih.gov/32205870 DMN0VS2 DI DMN0VS2 DMN0VS2 DN Lopinavir + ritonavir + ribavirin + interferon beta-1b DMN0VS2 MI TTV1095 DMN0VS2 MN COVID-19 RNA-directed RNA polymerase (RdRp) DMN0VS2 MT DTT DMN0VS2 MA Inhibitor DMN0VS2 RN Therapeutic options for the 2019 novel coronavirus (2019-nCoV). Nat Rev Drug Discov. 2020 Mar;19(3):149-150. DMN0VS2 RU https://pubmed.ncbi.nlm.nih.gov/32127666 DM0GZTD DI DM0GZTD DM0GZTD DN L-ornithine phenylacetate DM0GZTD MI TTSXVID DM0GZTD MN Nuclear factor NF-kappa-B (NFKB) DM0GZTD MT DTT DM0GZTD MA Modulator DM0GZTD RN Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41. DM0GZTD RU https://www.ncbi.nlm.nih.gov/pubmed/15950434 DME8O5K DI DME8O5K DME8O5K DN LOU064 DME8O5K MI TTGM6VW DME8O5K MN Tyrosine-protein kinase BTK (ATK) DME8O5K MT DTT DME8O5K MA Inhibitor DME8O5K RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DME8O5K RU http://phrma-docs.phrma.org/files/dmfile/MID_Skin_Diseases_2018_9_FINAL.pdf DMIV9ZE DI DMIV9ZE DMIV9ZE DN LOXORIBINE DMIV9ZE MI TTRJ1K4 DMIV9ZE MN Toll-like receptor 7 (TLR7) DMIV9ZE MT DTT DMIV9ZE MA Agonist DMIV9ZE RN The Toll-like receptor 7 (TLR7)-specific stimulus loxoribine uncovers a strong relationship within the TLR7, 8 and 9 subfamily. Eur J Immunol. 2003 Nov;33(11):2987-97. DMIV9ZE RU https://pubmed.ncbi.nlm.nih.gov/14579267 DM7BN5W DI DM7BN5W DM7BN5W DN LPN023 DM7BN5W MI TTA0P7K DM7BN5W MN Complement factor B (CFB) DM7BN5W MT DTT DM7BN5W MA Inhibitor DM7BN5W RN Complement Inhibitors in Clinical Trials for Glomerular Diseases. Front Immunol. 2019 Sep 27;10:2166. DM7BN5W RU https://pubmed.ncbi.nlm.nih.gov/31611870 DMZQBCL DI DMZQBCL DMZQBCL DN LR3001 DMZQBCL MI TT8V13P DMZQBCL MN Myb messenger RNA (MYB mRNA) DMZQBCL MT DTT DMZQBCL RN Genta obtains orphan drug designation for C-Myb Antisense (LR3001) in chronic myelocytic leukemia. Genta. 2005. DMZQBCL RU http://www.drugs.com/news/genta-obtains-orphan-designation-c-myb-antisense-lr3001-chronic-myelocytic-leukemia-3031.html DM0TZPL DI DM0TZPL DM0TZPL DN LS-71719 DM0TZPL MI DEPR1Y7 DM0TZPL MN Beta-galactosidase (bgaB) DM0TZPL MT DME DM0TZPL MA Metabolism DM0TZPL RN Diverse galactooligosaccharides consumption by bifidobacteria: implications of beta-galactosidase--LacS operon. Biosci Biotechnol Biochem. 2015;79(4):664-72. DM0TZPL RU https://pubmed.ncbi.nlm.nih.gov/25483279 DME26RS DI DME26RS DME26RS DN LTB4 DME26RS MI DEFCMPI DME26RS MN Leukotriene B4 omega-hydroxylase (CYP4F3) DME26RS MT DME DME26RS MA Metabolism DME26RS RN Leukotriene B4: metabolism and signal transduction. Arch Biochem Biophys. 2001 Jan 15;385(2):231-41. DME26RS RU https://www.ncbi.nlm.nih.gov/pubmed/?term=11368003 DME26RS DI DME26RS DME26RS DN LTB4 DME26RS MI TTN53ZF DME26RS MN Leukotriene B4 receptor 1 (LTB4R) DME26RS MT DTT DME26RS MA Agonist DME26RS RN LTB4 promotes insulin resistance in obese mice by acting on macrophages, hepatocytes and myocytes. Nat Med. 2015 Mar;21(3):239-47. DME26RS RU https://pubmed.ncbi.nlm.nih.gov/25706874 DME26RS DI DME26RS DME26RS DN LTB4 DME26RS MI TTVJX54 DME26RS MN Leukotriene B4 receptor 2 (LTB4R2) DME26RS MT DTT DME26RS MA Inhibitor DME26RS RN Diaryl ether/carboxylic acid derivatives of LY255283: Receptor antagonists of leukotriene B4, Bioorg. Med. Chem. Lett. 3(10):1985-1990 (1993). DME26RS RU http://www.sciencedirect.com/science/article/pii/S0960894X01810003 DMXEQ0R DI DMXEQ0R DMXEQ0R DN LTX-109 DMXEQ0R MI TTXT4D5 DMXEQ0R MN Bacterial Cell membrane (Bact CM) DMXEQ0R MT DTT DMXEQ0R MA Modulator DMXEQ0R RN A synthetic antimicrobial peptidomimetic (LTX 109): stereochemical impact on membrane disruption. J Med Chem. 2011 Aug 25;54(16):5786-95. DMXEQ0R RU https://pubmed.ncbi.nlm.nih.gov/21732630 DMJOYNZ DI DMJOYNZ DMJOYNZ DN Lu AF11167 DMJOYNZ MI TTJW4LU DMJOYNZ MN Phosphodiesterase 10A (PDE10) DMJOYNZ MT DTT DMJOYNZ MA Inhibitor DMJOYNZ RN PDE10A Inhibitors-Clinical Failure or Window Into Antipsychotic Drug Action?. Front Neurosci. 2021 Jan 20;14:600178. DMJOYNZ RU https://pubmed.ncbi.nlm.nih.gov/33551724 DM2ZUXK DI DM2ZUXK DM2ZUXK DN Lu-AA34893 DM2ZUXK MI TT85JO3 DM2ZUXK MN 5-HT receptor (5HTR) DM2ZUXK MT DTT DM2ZUXK MA Modulator DM2ZUXK RN Encyclopedia of Psychopharmacology. Ian Stolerman. 2010. Page(105). DM2ZUXK RU https://books.google.com.hk/books?id=qoyYobgX0uwC&pg=PA105&lpg=PA105&dq=Lu-AA34893++Serotonin+transporter&source=bl&ots=Y8wHg_Wpnq&sig=QOjSsHQcRslsmIZnyU6GU1bGY_s&hl=zh-CN&sa=X&ved=0CDAQ6AEwA2oVChMIwZvmieS7yAIVAsKOCh2rAgWU#v=onepage&q=Lu-AA34893%20%20Serotonin%20transporter&f=false DM2ZUXK DI DM2ZUXK DM2ZUXK DN Lu-AA34893 DM2ZUXK MI TT3ROYC DM2ZUXK MN Serotonin transporter (SERT) DM2ZUXK MT DTT DM2ZUXK MA Modulator DM2ZUXK RN Encyclopedia of Psychopharmacology. Ian Stolerman. 2010. Page(105). DM2ZUXK RU https://books.google.com.hk/books?id=qoyYobgX0uwC&pg=PA105&lpg=PA105&dq=Lu-AA34893++Serotonin+transporter&source=bl&ots=Y8wHg_Wpnq&sig=QOjSsHQcRslsmIZnyU6GU1bGY_s&hl=zh-CN&sa=X&ved=0CDAQ6AEwA2oVChMIwZvmieS7yAIVAsKOCh2rAgWU#v=onepage&q=Lu-AA34893%20%20Serotonin%20transporter&f=false DM34FWR DI DM34FWR DM34FWR DN Lu-AA39959 DM34FWR MI TTM7WCE DM34FWR MN Ion channel unspecific (IC) DM34FWR MT DTT DM34FWR MA Modulator DM34FWR RN Lundbeck: leading the way in the treatment of CNS disorders. DM34FWR RU http://onlinelibrary.wiley.com/doi/10.1002/fps.78/pdf DMY2L7V DI DMY2L7V DMY2L7V DN Lucatumumab DMY2L7V MI TTIJP3Q DMY2L7V MN TNF related activation protein (CD40LG) DMY2L7V MT DTT DMY2L7V MA Modulator DMY2L7V RN Phase I study of the anti-CD40 humanized monoclonal antibody lucatumumab (HCD122) in relapsed chronic lymphocytic leukemia.Leuk Lymphoma.2012 Nov;53(11):2136-42. DMY2L7V RU https://www.ncbi.nlm.nih.gov/pubmed/22475052 DMCKNBA DI DMCKNBA DMCKNBA DN Lufironil DMCKNBA MI TTNH25W DMCKNBA MN Prolyl 4-hydroxylasesubunit alpha-1 (P4HA1) DMCKNBA MT DTT DMCKNBA MA Modulator DMCKNBA RN Interference in clinical laboratory tests, with special regard to the bilirubin assay: effects of a metabolite of the new prolyl 4-hydroxylase inhibitor, Lufironil. Eur J Clin Chem Clin Biochem. 1994Jul;32(7):515-20. DMCKNBA RU https://pubmed.ncbi.nlm.nih.gov/7981331 DMGWZ93 DI DMGWZ93 DMGWZ93 DN Lulizumab pegol DMGWZ93 MI TTQ13FT DMGWZ93 MN T-cell-specific surface glycoprotein CD28 (CD28) DMGWZ93 MT DTT DMGWZ93 MA Modulator DMGWZ93 RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMGWZ93 RU http://phrma-docs.phrma.org/files/dmfile/medicines-in-development-drug-list-autoimmune-diseases.pdf DMQZXDW DI DMQZXDW DMQZXDW DN Lum001 DMQZXDW MI TTPI1M5 DMQZXDW MN Ileal sodium/bile acid cotransporter (SLC10A2) DMQZXDW MT DTT DMQZXDW MA Inhibitor DMQZXDW RN Current research on the treatment of primary sclerosing cholangitis. Intractable Rare Dis Res. 2015 Feb; 4(1): 1-6. DMQZXDW RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4322589/ DMQZXDW DI DMQZXDW DMQZXDW DN Lum001 DMQZXDW MI TTWZRY5 DMQZXDW MN Sodium/bile acid cotransporter (SLC10A1) DMQZXDW MT DTT DMQZXDW MA Inhibitor DMQZXDW RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMQZXDW RU http://phrma-docs.phrma.org/files/dmfile/medicines-in-development-drug-list-autoimmune-diseases.pdf DMCLWDJ DI DMCLWDJ DMCLWDJ DN Lumacaftor DMCLWDJ MI TTRLZHP DMCLWDJ MN cAMP-dependent chloride channel (CFTR) DMCLWDJ MT DTT DMCLWDJ MA Regulator DMCLWDJ RN A CFTR corrector (lumacaftor) and a CFTR potentiator (ivacaftor) for treatment of patients with cystic fibrosis who have a phe508del CFTR mutation: a phase 2 randomised controlled trial. Lancet Respir Med. 2014 Jul;2(7):527-38. DMCLWDJ RU https://pubmed.ncbi.nlm.nih.gov/24973281 DMLTI39 DI DMLTI39 DMLTI39 DN Lumiliximab DMLTI39 MI TTCH6MU DMLTI39 MN Lymphocyte IgE receptor (CD23) DMLTI39 MT DTT DMLTI39 RN Anti-CD23 monoclonal antibody, lumiliximab, inhibited allergen-induced responses in antigen-presenting cells and T cells from atopic subjects. J Allergy Clin Immunol. 2005 Oct;116(4):780-8. DMLTI39 RU https://pubmed.ncbi.nlm.nih.gov/16210051 DMLRU9I DI DMLRU9I DMLRU9I DN Lunacalcipol DMLRU9I MI TT82UI1 DMLRU9I MN Cytochrome P450 24 (CYP24A1) DMLRU9I MT DTT DMLRU9I MA Inhibitor DMLRU9I RN Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800022679) DMLRU9I RU http://adisinsight.springer.com/drugs/800022679 DMZ2XAP DI DMZ2XAP DMZ2XAP DN LX-1031 DMZ2XAP MI TT7ZK9C DMZ2XAP MN Tryptophan 5-hydroxylase (TPH) DMZ2XAP MT DTT DMZ2XAP MA Inhibitor DMZ2XAP RN LX-1031, a tryptophan 5-hydroxylase inhibitor that reduces 5-HT levels for the potential treatment of irritable bowel syndrome. IDrugs. 2010 Dec;13(12):921-8. DMZ2XAP RU https://pubmed.ncbi.nlm.nih.gov/21154152 DMLA8H3 DI DMLA8H3 DMLA8H3 DN LX2931 DMLA8H3 MI TT618Q2 DMLA8H3 MN Sphingosine-1-phosphate lyase 1 (SGPL1) DMLA8H3 MT DTT DMLA8H3 MA Inhibitor DMLA8H3 RN Targeting the sphingosine-1-phosphate axis in cancer, inflammation and beyond. Nat Rev Drug Discov. 2013 Sep;12(9):688-702. DMLA8H3 RU https://pubmed.ncbi.nlm.nih.gov/23954895 DMLBD5I DI DMLBD5I DMLBD5I DN LXE408 DMLBD5I MI TTSVQWU DMLBD5I MN Leishmania major Proteasome (Leishm Proteasome) DMLBD5I MT DTT DMLBD5I MA Inhibitor DMLBD5I RN Discovery and Characterization of Clinical Candidate LXE408 as a Kinetoplastid-Selective Proteasome Inhibitor for the Treatment of Leishmaniases. J Med Chem. 2020 Oct 8;63(19):10773-10781. DMLBD5I RU https://pubmed.ncbi.nlm.nih.gov/32667203 DM5IX9M DI DM5IX9M DM5IX9M DN LY-156735 DM5IX9M MI TT0WAIE DM5IX9M MN Melatonin receptor type 1A (MTNR1A) DM5IX9M MT DTT DM5IX9M MA Agonist DM5IX9M RN Melatonin and sleep in aging population. Exp Gerontol. 2005 Dec;40(12):911-25. DM5IX9M RU https://pubmed.ncbi.nlm.nih.gov/16183237 DMTBFE4 DI DMTBFE4 DMTBFE4 DN LY2090314 DMTBFE4 MI TTRZQE3 DMTBFE4 MN Glycogen synthase kinase-3 alpha (GSK-3A) DMTBFE4 MT DTT DMTBFE4 MA Modulator DMTBFE4 RN Glycogen synthase kinase 3 (GSK-3) inhibitors: a patent update (2014-2015).Expert Opin Ther Pat. 2017 Jun;27(6):657-666. DMTBFE4 RU https://www.ncbi.nlm.nih.gov/pubmed/27828716 DMTBFE4 DI DMTBFE4 DMTBFE4 DN LY2090314 DMTBFE4 MI TTRSMW9 DMTBFE4 MN Glycogen synthase kinase-3 beta (GSK-3B) DMTBFE4 MT DTT DMTBFE4 MA Modulator DMTBFE4 RN Glycogen synthase kinase 3 (GSK-3) inhibitors: a patent update (2014-2015).Expert Opin Ther Pat. 2017 Jun;27(6):657-666. DMTBFE4 RU https://www.ncbi.nlm.nih.gov/pubmed/27828716 DMU81BH DI DMU81BH DMU81BH DN LY-2189102 DMU81BH MI TTRYK0X DMU81BH MN Interleukin-1 beta (IL1B) DMU81BH MT DTT DMU81BH RN Double-blind, randomized study evaluating the glycemic and anti-inflammatory effects of subcutaneous LY2189102, a neutralizing IL-1beta antibody, in patients with type 2 diabetes. Diabetes Care. 2013Aug;36(8):2239-46. DMU81BH RU https://pubmed.ncbi.nlm.nih.gov/23514733 DMH3YKJ DI DMH3YKJ DMH3YKJ DN LY2382770 DMH3YKJ MI TTO3HT7 DMH3YKJ MN Transforming growth factor beta (TGFB) DMH3YKJ MT DTT DMH3YKJ MA Inhibitor DMH3YKJ RN A phase I dose-escalation study to a predefined dose of a transforming growth factor-1 monoclonal antibody (TM1) in patients with metastatic cancer. Int J Oncol. 2014 Dec;45(6):2221-31. DMH3YKJ RU https://pubmed.ncbi.nlm.nih.gov/25270361 DMZOIP4 DI DMZOIP4 DMZOIP4 DN LY-2409021 DMZOIP4 MI TT9O6WS DMZOIP4 MN Glucagon receptor (GCGR) DMZOIP4 MT DTT DMZOIP4 MA Antagonist DMZOIP4 RN Short-term administration of the glucagon receptor antagonist LY2409021 lowers blood glucose in healthy people and in those with type 2 diabetes. Diabetes Obes Metab. 2015 Apr;17(4):414-22. DMZOIP4 RU https://pubmed.ncbi.nlm.nih.gov/25656305 DMKYMS2 DI DMKYMS2 DMKYMS2 DN LY-2428757 DMKYMS2 MI TTVIMDE DMKYMS2 MN Glucagon-like peptide 1 receptor (GLP1R) DMKYMS2 MT DTT DMKYMS2 MA Stimulator DMKYMS2 RN Role and development of GLP-1 receptor agonists in the management of diabetes. Diabetes Metab Syndr Obes. 2009; 2: 37-49. DMKYMS2 RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2818016/ DMLTSDC DI DMLTSDC DMLTSDC DN LY-2456302 DMLTSDC MI TTQW87Y DMLTSDC MN Opioid receptor kappa (OPRK1) DMLTSDC MT DTT DMLTSDC MA Antagonist DMLTSDC RN LY2456302 is a novel, potent, orally-bioavailable small molecule kappa-selective antagonist with activity in animal models predictive of efficacy in mood and addictive disorders. Neuropharmacology. 2014 Feb;77:131-44. DMLTSDC RU https://pubmed.ncbi.nlm.nih.gov/24071566 DMM5JAN DI DMM5JAN DMM5JAN DN LY2495655 DMM5JAN MI TTSWPH8 DMM5JAN MN Growth/differentiation factor 8 (GDF-8) DMM5JAN MT DTT DMM5JAN MA Modulator DMM5JAN RN Myostatin inhibitors as therapies for muscle wasting associated with cancer and other disorders. Curr Opin Support Palliat Care. 2013 November; 7(4): 352-360. DMM5JAN RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3819341/ DMCV602 DI DMCV602 DMCV602 DN LY2523355 DMCV602 MI TTTRP0H DMCV602 MN Kinesin-like protein KIF11 (KIF11) DMCV602 MT DTT DMCV602 MA Modulator DMCV602 RN Kinesins and cancer. Nat Rev Cancer. 2012 Jul 24;12(8):527-39. DMCV602 RU https://pubmed.ncbi.nlm.nih.gov/22825217 DMTVU2Q DI DMTVU2Q DMTVU2Q DN LY2541546 DMTVU2Q MI TTYRO4F DMTVU2Q MN Sclerostin (SOST) DMTVU2Q MT DTT DMTVU2Q RN Rat-specific decreases in platelet count caused by a humanized monoclonal antibody against sclerostin. Toxicol Sci. 2012 Feb;125(2):586-94. DMTVU2Q RU https://pubmed.ncbi.nlm.nih.gov/22106037 DM81UJW DI DM81UJW DM81UJW DN LY-2590443 DM81UJW MI TTZPO1L DM81UJW MN Substance-P receptor (TACR1) DM81UJW MT DTT DM81UJW MA Antagonist DM81UJW RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 360). DM81UJW RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=360 DMMI0RH DI DMMI0RH DMMI0RH DN LY-2599506 DMMI0RH MI TTDLNGZ DMMI0RH MN Glucokinase (GCK) DMMI0RH MT DTT DMMI0RH MA Inhibitor DMMI0RH RN This week in therapeutics Endocrine disease. SciBX 2(37); doi:10.1038/scibx.2009.1408. Sept. 24, 2009 DMMI0RH RU http://www.nature.com/scibx/journal/v2/n37/pdf/scibx.2009.1408.pdf DMCXRZF DI DMCXRZF DMCXRZF DN LY2603618 DMCXRZF MI TTTU902 DMCXRZF MN Checkpoint kinase-1 (CHK1) DMCXRZF MT DTT DMCXRZF MA Modulator DMCXRZF RN Characterization and preclinical development of LY2603618: a selective and potent Chk1 inhibitor. Invest New Drugs. 2014 Apr;32(2):213-26. DMCXRZF RU https://pubmed.ncbi.nlm.nih.gov/24114124 DMCXRZF DI DMCXRZF DMCXRZF DN LY2603618 DMCXRZF MI DECB0K3 DMCXRZF MN Cytochrome P450 2D6 (CYP2D6) DMCXRZF MT DME DMCXRZF MA Metabolism DMCXRZF RN Disposition and metabolism of LY2603618, a Chk-1 inhibitor following intravenous administration in patients with advanced and/or metastatic solid tumors. Xenobiotica. 2014 Sep;44(9):827-41. DMCXRZF RU https://www.ncbi.nlm.nih.gov/pubmed/?term=24666335 DMCXRZF DI DMCXRZF DMCXRZF DN LY2603618 DMCXRZF MI DE4LYSA DMCXRZF MN Cytochrome P450 3A4 (CYP3A4) DMCXRZF MT DME DMCXRZF MA Metabolism DMCXRZF RN Disposition and metabolism of LY2603618, a Chk-1 inhibitor following intravenous administration in patients with advanced and/or metastatic solid tumors. Xenobiotica. 2014 Sep;44(9):827-41. DMCXRZF RU https://www.ncbi.nlm.nih.gov/pubmed/?term=24666335 DM4XMF7 DI DM4XMF7 DM4XMF7 DN LY2606368 DM4XMF7 MI TTTU902 DM4XMF7 MN Checkpoint kinase-1 (CHK1) DM4XMF7 MT DTT DM4XMF7 MA Inhibitor DM4XMF7 RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DM4XMF7 RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DM4EF9Y DI DM4EF9Y DM4EF9Y DN LY-2608204 DM4EF9Y MI TTDLNGZ DM4EF9Y MN Glucokinase (GCK) DM4EF9Y MT DTT DM4EF9Y MA Activator DM4EF9Y RN Clinical pipeline report, company report or official report of Eli Lilly. DM4EF9Y RU http://www.lillytrials.com/initiated/initiated.html DMFGNB4 DI DMFGNB4 DMFGNB4 DN LY-2623091 DMFGNB4 MI TT26PHO DMFGNB4 MN Mineralocorticoid receptor (MR) DMFGNB4 MT DTT DMFGNB4 MA Antagonist DMFGNB4 RN Nonsteroidal antagonists of the mineralocorticoid receptor. Curr Opin Nephrol Hypertens. 2015 Sep;24(5):417-24. DMFGNB4 RU https://pubmed.ncbi.nlm.nih.gov/26083526 DMTPQUA DI DMTPQUA DMTPQUA DN LY-2624803 DMTPQUA MI TTTIBOJ DMTPQUA MN Histamine H1 receptor (H1R) DMTPQUA MT DTT DMTPQUA MA Modulator DMTPQUA RN Current Phase II investigational therapies for insomnia. Expert Opin Investig Drugs. 2015 Mar;24(3):401-11. DMTPQUA RU https://pubmed.ncbi.nlm.nih.gov/25423562 DMZASMP DI DMZASMP DMZASMP DN LY2784544 DMZASMP MI TTRMX3V DMZASMP MN Janus kinase 2 (JAK-2) DMZASMP MT DTT DMZASMP MA Modulator DMZASMP RN Discovery and characterization of LY2784544, a small-molecule tyrosine kinase inhibitor of JAK2V617F. Blood Cancer J. 2013 Apr 12;3:e109. DMZASMP RU https://pubmed.ncbi.nlm.nih.gov/23584399 DM0KJDY DI DM0KJDY DM0KJDY DN LY2801653 DM0KJDY MI TTU8W4S DM0KJDY MN Protein kinase (PK) DM0KJDY MT DTT DM0KJDY MA Inhibitor DM0KJDY RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DM0KJDY RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DM0KJDY DI DM0KJDY DM0KJDY DN LY2801653 DM0KJDY MI TTNDSF4 DM0KJDY MN Proto-oncogene c-Met (MET) DM0KJDY MT DTT DM0KJDY MA Modulator DM0KJDY RN Clinical pipeline report, company report or official report of Eli Lilly. DM0KJDY RU http://www.lillyoncologypipeline.com/met-inhibitor.aspx DMO8IEZ DI DMO8IEZ DMO8IEZ DN LY-2828360 DMO8IEZ MI TTMSFAW DMO8IEZ MN Cannabinoid receptor 2 (CB2) DMO8IEZ MT DTT DMO8IEZ MA Agonist DMO8IEZ RN Recent Development of CB2 Selective and Peripheral CB1/CB2 Cannabinoid Receptor Ligands. Current Medicinal Chemistry . 10/2013; 21(2). DMO8IEZ RU http://www.researchgate.net/publication/258114758_Recent_Development_of_CB2_Selective_and_Peripheral_CB1CB2_Cannabinoid_Receptor_Ligands DMZ0DMY DI DMZ0DMY DMZ0DMY DN LY2874455 DMZ0DMY MI TTGJVQM DMZ0DMY MN Fibroblast growth factor receptor 2 (FGFR2) DMZ0DMY MT DTT DMZ0DMY MA Modulator DMZ0DMY RN Company report (Eli Lilly) (drug: LY2874455) DMZ0DMY RU http://www.lillyoncologypipeline.com/fgfr-inhibitor.aspx DMQV1OU DI DMQV1OU DMQV1OU DN LY-2875358 DMQV1OU MI TTNDSF4 DMQV1OU MN Proto-oncogene c-Met (MET) DMQV1OU MT DTT DMQV1OU RN Clinical pipeline report, company report or official report of Eli Lilly. DMQV1OU RU http://www.lillyoncologypipeline.com/met-antibody.aspx DMV14LM DI DMV14LM DMV14LM DN LY2886721 DMV14LM MI TT8JRS7 DMV14LM MN Beta-secretase (BACE) DMV14LM MT DTT DMV14LM MA Modulator DMV14LM RN Lessons from a BACE1 inhibitor trial: off-site but not off base.Alzheimers Dement.2014 Oct;10(5 Suppl):S411-9. DMV14LM RU https://www.ncbi.nlm.nih.gov/pubmed/24530026 DMRDEKZ DI DMRDEKZ DMRDEKZ DN LY2928057 DMRDEKZ MI TT6Y1PG DMRDEKZ MN Solute carrier family 40 member 1 (SLC40A1) DMRDEKZ MT DTT DMRDEKZ MA Modulator DMRDEKZ RN Targeting the Hepcidin-Ferroportin Axis to Develop New Treatment Strategies for Anemia of Chronic Disease and Anemia of Inflammation. Am J Hematol. 2012 April; 87(4): 392-400. DMRDEKZ RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3653431/ DM4N6EK DI DM4N6EK DM4N6EK DN LY293558 DM4N6EK MI TT0MYE2 DM4N6EK MN Glutamate receptor ionotropic kainate 1 (GRIK1) DM4N6EK MT DTT DM4N6EK MA Modulator DM4N6EK RN Pharmacogenetics of new analgesics. Br J Pharmacol. 2011 Jun;163(3):447-60. DM4N6EK RU https://pubmed.ncbi.nlm.nih.gov/20942817 DMB5L6Q DI DMB5L6Q DMB5L6Q DN LY-2940094 DMB5L6Q MI TTNT7K8 DMB5L6Q MN Nociceptin receptor (OPRL1) DMB5L6Q MT DTT DMB5L6Q MA Modulator DMB5L6Q RN Emerging mechanisms and treatments for depression beyond SSRIs and SNRIs. Biochemical Pharmacology Volume 95, Issue 2, 15 May 2015, Pages 81-97. DMB5L6Q RU http://www.sciencedirect.com/science/article/pii/S0006295215001562 DML6XWR DI DML6XWR DML6XWR DN LY2944876 DML6XWR MI TT9O6WS DML6XWR MN Glucagon receptor (GCGR) DML6XWR MT DTT DML6XWR MA Modulator DML6XWR RN Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41. DML6XWR RU https://www.ncbi.nlm.nih.gov/pubmed/15950434 DML6XWR DI DML6XWR DML6XWR DN LY2944876 DML6XWR MI TTVIMDE DML6XWR MN Glucagon-like peptide 1 receptor (GLP1R) DML6XWR MT DTT DML6XWR MA Modulator DML6XWR RN Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41. DML6XWR RU https://www.ncbi.nlm.nih.gov/pubmed/15950434 DMRVEHY DI DMRVEHY DMRVEHY DN LY3012212 DMRVEHY MI TT2Q6G1 DMRVEHY MN Vascular endothelial growth factor receptor 1 (FLT-1) DMRVEHY MT DTT DMRVEHY MA Modulator DMRVEHY RN Icrucumab, a fully human monoclonal antibody against the vascular endothelial growth factor receptor-1, in the treatment of patients with advanced solid malignancies: a Phase 1 study. Invest New Drugs. 2014 Apr;32(2):303-11. DMRVEHY RU https://pubmed.ncbi.nlm.nih.gov/23903897 DMFMKQ3 DI DMFMKQ3 DMFMKQ3 DN LY3015014 DMFMKQ3 MI TTBRG7E DMFMKQ3 MN Proprotein convertase subtilisin/kexin type 9 (PCSK9) DMFMKQ3 MT DTT DMFMKQ3 RN The dyslipidaemia market. Nat Rev Drug Discov. 2014 Nov;13(11):807-8. DMFMKQ3 RU https://pubmed.ncbi.nlm.nih.gov/25323928 DMD9KYF DI DMD9KYF DMD9KYF DN LY3023414 DMD9KYF MI TTEUNMR DMD9KYF MN PI3-kinase alpha (PIK3CA) DMD9KYF MT DTT DMD9KYF MA Modulator DMD9KYF RN Company report (Lilly) DMD9KYF RU http://www.lillyoncologypipeline.com/pi3kmtor-dual-inhibitor.aspx DMD9KYF DI DMD9KYF DMD9KYF DN LY3023414 DMD9KYF MI TTCJG29 DMD9KYF MN Serine/threonine-protein kinase mTOR (mTOR) DMD9KYF MT DTT DMD9KYF MA Modulator DMD9KYF RN Company report (Lilly) DMD9KYF RU http://www.lillyoncologypipeline.com/pi3kmtor-dual-inhibitor.aspx DMDFZK8 DI DMDFZK8 DMDFZK8 DN LY3113593 DMDFZK8 MI TT07RIB DMDFZK8 MN Bone morphogenetic protein 6 (BMP6) DMDFZK8 MT DTT DMDFZK8 MA Inhibitor DMDFZK8 RN Targeting the hepcidin-ferroportin pathway in anaemia of chronic kidney disease. Br J Clin Pharmacol. 2019 May;85(5):935-948. DMDFZK8 RU https://pubmed.ncbi.nlm.nih.gov/30677788 DMAC457 DI DMAC457 DMAC457 DN LY3127804 DMAC457 MI TT0APVH DMAC457 MN HUMAN angiopoietin-2 (ANG-2) DMAC457 MT DTT DMAC457 MA Inhibitor DMAC457 RN Updates: Lilly's Global COVID-19 Response DMAC457 RU https://www.lilly.com/news/stories/coronavirus-covid19-global-response DM7IFNB DI DM7IFNB DM7IFNB DN LY3202626 DM7IFNB MI TT8JRS7 DM7IFNB MN Beta-secretase (BACE) DM7IFNB MT DTT DM7IFNB MA Inhibitor DM7IFNB RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DM7IFNB RU http://phrma-docs.phrma.org/files/dmfile/MID_Neurological-Disorders-Drug-List_2018.pdf DMGMC8H DI DMGMC8H DMGMC8H DN LY333531 DMGMC8H MI DE4LYSA DMGMC8H MN Cytochrome P450 3A4 (CYP3A4) DMGMC8H MT DME DMGMC8H MA Metabolism DMGMC8H RN The interactions of a selective protein kinase C beta inhibitor with the human cytochromes P450. Drug Metab Dispos. 2002 Sep;30(9):957-61. DMGMC8H RU https://www.ncbi.nlm.nih.gov/pubmed/?term=12167559 DMGMC8H DI DMGMC8H DMGMC8H DN LY333531 DMGMC8H MI TT9SL3Q DMGMC8H MN Polypeptide deformylase (PDF) DMGMC8H MT DTT DMGMC8H MA Inhibitor DMGMC8H RN Three-dimensional structure of M. tuberculosis dihydrofolate reductase reveals opportunities for the design of novel tuberculosis drugs. J Mol Biol. 2000 Jan 14;295(2):307-23. DMGMC8H RU https://pubmed.ncbi.nlm.nih.gov/10623528 DMGMC8H DI DMGMC8H DMGMC8H DN LY333531 DMGMC8H MI TTYPXQF DMGMC8H MN Protein kinase C beta (PRKCB) DMGMC8H MT DTT DMGMC8H MA Inhibitor DMGMC8H RN Protein kinase C beta inhibition attenuates the progression of experimental diabetic nephropathy in the presence of continued hypertension. Diabetes. 2003 Feb;52(2):512-8. DMGMC8H RU https://pubmed.ncbi.nlm.nih.gov/12540629 DM43O9N DI DM43O9N DM43O9N DN LY-334370 DM43O9N MI TT0MI3F DM43O9N MN 5-HT 1F receptor (HTR1F) DM43O9N MT DTT DM43O9N MA Modulator DM43O9N RN Selective seratonin 1F (5-HT(1F)) receptor agonist LY334370 for acute migraine: a randomised controlled trial. Lancet. 2001 Oct 13;358(9289):1230-4. DM43O9N RU https://www.ncbi.nlm.nih.gov/pubmed/11675061 DMD09CT DI DMD09CT DMD09CT DN LY-362884 DMD09CT MI TTMXGCW DMD09CT MN Adrenergic receptor beta-3 (ADRB3) DMD09CT MT DTT DMD09CT MA Agonist DMD09CT RN Emerging drugs for obesity: linking novel biological mechanisms to pharmaceutical pipelines. Expert Opin Emerg Drugs. 2005 Aug;10(3):643-60. DMD09CT RU https://pubmed.ncbi.nlm.nih.gov/16083333 DMZCU7I DI DMZCU7I DMZCU7I DN LY-377604 DMZCU7I MI TTMXGCW DMZCU7I MN Adrenergic receptor beta-3 (ADRB3) DMZCU7I MT DTT DMZCU7I MA Agonist DMZCU7I RN Combination of a Beta Adrenoceptor Modulator and a Norepinephrine-Serotonin Uptake Inhibitor for the Treatment of Obesity. ACS Med Chem Lett. 2011 August 11; 2(8): 583-586. DMZCU7I RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4018109/ DM8OG0J DI DM8OG0J DM8OG0J DN LY-517717 DM8OG0J MI TTCIHJA DM8OG0J MN Coagulation factor Xa (F10) DM8OG0J MT DTT DM8OG0J MA Inhibitor DM8OG0J RN Semuloparin for the prevention of venous thromboembolic events in cancer patients. Drugs Today (Barc). 2012 Jul;48(7):451-7. DM8OG0J RU https://pubmed.ncbi.nlm.nih.gov/22844656 DMBM2I9 DI DMBM2I9 DMBM2I9 DN LY-518674 DMBM2I9 MI TTJ584C DMBM2I9 MN Peroxisome proliferator-activated receptor alpha (PPARA) DMBM2I9 MT DTT DMBM2I9 MA Agonist DMBM2I9 RN Potent and selective PPAR-alpha agonist LY518674 upregulates both ApoA-I production and catabolism in human subjects with the metabolic syndrome. Arterioscler Thromb Vasc Biol. 2009 Jan;29(1):140-6. DMBM2I9 RU https://pubmed.ncbi.nlm.nih.gov/18988892 DMMSBW5 DI DMMSBW5 DMMSBW5 DN LY-545694 DMMSBW5 MI TTDXZ24 DMMSBW5 MN Glutamate receptor ionotropic (GRI) DMMSBW5 MT DTT DMMSBW5 MA Antagonist DMMSBW5 RN Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800019739) DMMSBW5 RU http://adisinsight.springer.com/drugs/800019739 DMP05GL DI DMP05GL DMP05GL DN LYC-30937 DMP05GL MI TT5WKM8 DMP05GL MN ATP phosphatase (ATPase) DMP05GL MT DTT DMP05GL MA Modulator DMP05GL RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMP05GL RU http://phrma-docs.phrma.org/files/dmfile/medicines-in-development-drug-list-autoimmune-diseases.pdf DMV8WU9 DI DMV8WU9 DMV8WU9 DN LYC-55716 DMV8WU9 MI TTGV6LY DMV8WU9 MN Nuclear receptor ROR-gamma (RORG) DMV8WU9 MT DTT DMV8WU9 MA Agonist DMV8WU9 RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMV8WU9 RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DM23Y6K DI DM23Y6K DM23Y6K DN LYS228 DM23Y6K MI TT85JMW DM23Y6K MN Bacterial Penicillin binding protein 3 (Bact mrcA) DM23Y6K MT DTT DM23Y6K MA Binder DM23Y6K RN Mode of Action of the Monobactam LYS228 and Mechanisms Decreasing In Vitro Susceptibility in Escherichia coli and Klebsiella pneumoniae. Antimicrob Agents Chemother. 2018 Sep 24;62(10):e01200-18. DM23Y6K RU https://pubmed.ncbi.nlm.nih.gov/30061293 DML0I2Z DI DML0I2Z DML0I2Z DN M118 DML0I2Z MI TT4QPUL DML0I2Z MN Antithrombin-III (ATIII) DML0I2Z MT DTT DML0I2Z MA Inhibitor DML0I2Z RN Clinical pipeline report, company report or official report of Momentapharma. DML0I2Z RU http://www.momentapharma.com/pipeline/adomiparin.php DMZ7YX3 DI DMZ7YX3 DMZ7YX3 DN M-16209 DMZ7YX3 MI TTFBNVI DMZ7YX3 MN Aldose reductase (AKR1B1) DMZ7YX3 MT DTT DMZ7YX3 MA Inhibitor DMZ7YX3 RN Effects of novel aldose reductase inhibitors, M16209 and M16287, on streptozotocin-induced diabetic neuropathy in rats. Eur J Pharmacol. 1991 Feb 7;193(2):185-91. DMZ7YX3 RU https://pubmed.ncbi.nlm.nih.gov/1828768 DMC5MQD DI DMC5MQD DMC5MQD DN M2951 DMC5MQD MI TTGM6VW DMC5MQD MN Tyrosine-protein kinase BTK (ATK) DMC5MQD MT DTT DMC5MQD MA Inhibitor DMC5MQD RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMC5MQD RU http://phrma-docs.phrma.org/files/dmfile/medicines-in-development-drug-list-autoimmune-diseases.pdf DMJCULI DI DMJCULI DMJCULI DN M7824 DMJCULI MI TT8ZLTI DMJCULI MN Programmed cell death 1 ligand 1 (PD-L1) DMJCULI MT DTT DMJCULI MA Inhibitor DMJCULI RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMJCULI RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DMJCULI DI DMJCULI DMJCULI DN M7824 DMJCULI MI TTNBFWK DMJCULI MN Programmed cell death protein 1 (PD-1) DMJCULI MT DTT DMJCULI RN Development of Inhibitors of the Programmed Cell Death-1/Programmed Cell Death-Ligand 1 Signaling Pathway.J Med Chem. 2019 Feb 28;62(4):1715-1730. DMJCULI RU https://pubmed.ncbi.nlm.nih.gov/30247903 DMJCULI DI DMJCULI DMJCULI DN M7824 DMJCULI MI TTO3HT7 DMJCULI MN Transforming growth factor beta (TGFB) DMJCULI MT DTT DMJCULI MA Inhibitor DMJCULI RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMJCULI RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DMQOBH4 DI DMQOBH4 DMQOBH4 DN mab 1-7F9 DMQOBH4 MI TT4UXPE DMQOBH4 MN MHC class I NK cell receptor 2DL1 (CD158A) DMQOBH4 MT DTT DMQOBH4 RN Genetic and antibody-mediated reprogramming of natural killer cell missing-self recognition in vivo. Proc Natl Acad Sci U S A. 2009 Aug 4;106(31):12879-84. DMQOBH4 RU https://pubmed.ncbi.nlm.nih.gov/19561305 DMQOBH4 DI DMQOBH4 DMQOBH4 DN mab 1-7F9 DMQOBH4 MI TTU0P73 DMQOBH4 MN MHC class I NK cell receptor 2DL2 (CD158b1) DMQOBH4 MT DTT DMQOBH4 RN Genetic and antibody-mediated reprogramming of natural killer cell missing-self recognition in vivo. Proc Natl Acad Sci U S A. 2009 Aug 4;106(31):12879-84. DMQOBH4 RU https://pubmed.ncbi.nlm.nih.gov/19561305 DMQOBH4 DI DMQOBH4 DMQOBH4 DN mab 1-7F9 DMQOBH4 MI TTEX3SI DMQOBH4 MN MHC class I NK cell receptor 2DL3 (CD158b2) DMQOBH4 MT DTT DMQOBH4 RN Genetic and antibody-mediated reprogramming of natural killer cell missing-self recognition in vivo. Proc Natl Acad Sci U S A. 2009 Aug 4;106(31):12879-84. DMQOBH4 RU https://pubmed.ncbi.nlm.nih.gov/19561305 DMBYDNE DI DMBYDNE DMBYDNE DN Managlinat dialanetil DMBYDNE MI TTWHDVK DMBYDNE MN Fructose-1,6-bisphosphatase (FBP) DMBYDNE MT DTT DMBYDNE MA Modulator DMBYDNE RN MB06322 (CS-917): A potent and selective inhibitor of fructose 1,6-bisphosphatase for controlling gluconeogenesis in type 2 diabetes. Proc Natl Acad Sci U S A. 2005 May 31;102(22):7970-5. DMBYDNE RU https://pubmed.ncbi.nlm.nih.gov/15911772 DMB4A8I DI DMB4A8I DMB4A8I DN MANOALIDE DMB4A8I MI TT9V5JH DMB4A8I MN Phospholipase A2 (PLA2G1B) DMB4A8I MT DTT DMB4A8I MA Modulator DMB4A8I RN Manoalide, a phospholipase A2 inhibitor, inhibits arachidonate incorporation and turnover in brain phospholipids of the awake rat. Neurochem Res. 1998 Oct;23(10):1251-7. DMB4A8I RU https://www.ncbi.nlm.nih.gov/pubmed/9804280 DMGQ175 DI DMGQ175 DMGQ175 DN Mapatumumab DMGQ175 MI TT5WLRX DMGQ175 MN TRAIL receptor 1 (TRAIL-R1) DMGQ175 MT DTT DMGQ175 MA Modulator DMGQ175 RN National Cancer Institute Drug Dictionary (drug id 486626). DMGQ175 RU http://www.cancer.gov/publications/dictionaries/cancer-drug?cdrid=486626 DMDTI0L DI DMDTI0L DMDTI0L DN Masilukast DMDTI0L MI TTGKOY9 DMDTI0L MN Leukotriene CysLT1 receptor (CYSLTR1) DMDTI0L MT DTT DMDTI0L MA Modulator DMDTI0L RN Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41. DMDTI0L RU https://www.ncbi.nlm.nih.gov/pubmed/15950434 DM2458E DI DM2458E DM2458E DN Matuzumab DM2458E MI TTGKNB4 DM2458E MN Epidermal growth factor receptor (EGFR) DM2458E MT DTT DM2458E RN Matuzumab binding to EGFR prevents the conformational rearrangement required for dimerization. Cancer Cell. 2008 Apr;13(4):365-73. DM2458E RU https://pubmed.ncbi.nlm.nih.gov/18394559 DMMVFRC DI DMMVFRC DMMVFRC DN Mavrilimumab DMMVFRC MI TT6MP2Z DMMVFRC MN GMCSFR-alpha (CSF2RA) DMMVFRC MT DTT DMMVFRC RN Clinical pipeline report, company report or official report of MedImmune (2011). DMMVFRC RU http://www.medimmune.com/research_pipeline.aspx DMMVFRC DI DMMVFRC DMMVFRC DN Mavrilimumab DMMVFRC MI TTNYZG2 DMMVFRC MN Granulocyte-macrophage colony-stimulating factor (CSF2) DMMVFRC MT DTT DMMVFRC MA Antagonist DMMVFRC RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMMVFRC RU http://phrma-docs.phrma.org/files/dmfile/medicines-in-development-drug-list-autoimmune-diseases.pdf DMWLIPJ DI DMWLIPJ DMWLIPJ DN MAXY-G34 DMWLIPJ MI TTC70AJ DMWLIPJ MN Granulocyte colony-stimulating factor receptor (G-CSF-R) DMWLIPJ MT DTT DMWLIPJ MA Agonist DMWLIPJ RN Survival efficacy of the PEGylated G-CSFs Maxy-G34 and neulasta in a mouse model of lethal H-ARS, and residual bone marrow damage in treated survivors. Health Phys. 2014 Jan;106(1):21-38. DMWLIPJ RU https://pubmed.ncbi.nlm.nih.gov/24276547 DMJKHVX DI DMJKHVX DMJKHVX DN Mazapertine succinate DMJKHVX MI TTSQIFT DMJKHVX MN 5-HT 1A receptor (HTR1A) DMJKHVX MT DTT DMJKHVX MA Modulator DMJKHVX RN Dual ligands targeting dopamine D2 and serotonin 5-HT1A receptors as new antipsychotical or anti-Parkinsonian agents.Curr Med Chem.2014;21(4):437-57. DMJKHVX RU https://www.ncbi.nlm.nih.gov/pubmed/24164194 DMJKHVX DI DMJKHVX DMJKHVX DN Mazapertine succinate DMJKHVX MI TTEX248 DMJKHVX MN Dopamine D2 receptor (D2R) DMJKHVX MT DTT DMJKHVX MA Modulator DMJKHVX RN Dual ligands targeting dopamine D2 and serotonin 5-HT1A receptors as new antipsychotical or anti-Parkinsonian agents.Curr Med Chem.2014;21(4):437-57. DMJKHVX RU https://www.ncbi.nlm.nih.gov/pubmed/24164194 DMHU8SJ DI DMHU8SJ DMHU8SJ DN MB07803 DMHU8SJ MI TTWHDVK DMHU8SJ MN Fructose-1,6-bisphosphatase (FBP) DMHU8SJ MT DTT DMHU8SJ MA Modulator DMHU8SJ RN Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41. DMHU8SJ RU https://www.ncbi.nlm.nih.gov/pubmed/15950434 DM6JTSZ DI DM6JTSZ DM6JTSZ DN MB-07811 DM6JTSZ MI DE4LYSA DM6JTSZ MN Cytochrome P450 3A4 (CYP3A4) DM6JTSZ MT DME DM6JTSZ MA Metabolism DM6JTSZ RN Preclinical pharmacokinetics of a HepDirect prodrug of a novel phosphonate-containing thyroid hormone receptor agonist. Drug Metab Dispos. 2008 Nov;36(11):2393-403. DM6JTSZ RU https://www.ncbi.nlm.nih.gov/pubmed/?term=18703645 DM6JTSZ DI DM6JTSZ DM6JTSZ DN MB-07811 DM6JTSZ MI TTGER3L DM6JTSZ MN Thyroid hormone receptor beta (THRB) DM6JTSZ MT DTT DM6JTSZ MA Modulator DM6JTSZ RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 589). DM6JTSZ RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=589 DMLPNVS DI DMLPNVS DMLPNVS DN MB-102 DMLPNVS MI TTENHJ0 DMLPNVS MN Interleukin 3 receptor alpha (IL3RA) DMLPNVS MT DTT DMLPNVS MA CAR-T-Cell-Therapy DMLPNVS RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMLPNVS RU http://phrma-docs.phrma.org/files/dmfile/MID_Immuno-Oncology-2017_Drug-List1.pdf DM3RBJW DI DM3RBJW DM3RBJW DN MB-11055 DM3RBJW MI TTLAFZV DM3RBJW MN AMP-activated protein kinase (AMPK) DM3RBJW MT DTT DM3RBJW MA Modulator DM3RBJW RN Antidiabetes and antiobesity effect of cryptotanshinone via activation of AMP-activated protein kinase.Mol Pharmacol.2007 Jul;72(1):62-72. DM3RBJW RU https://www.ncbi.nlm.nih.gov/pubmed/17429005 DMRSN2C DI DMRSN2C DMRSN2C DN MB-12066 DMRSN2C MI TTUF2HO DMRSN2C MN NAD-dependent deacetylase sirtuin-1 (SIRT1) DMRSN2C MT DTT DMRSN2C MA Modulator DMRSN2C RN Pharmacological activation of Sirt1 ameliorates polyglutamine-induced toxicity through the regulation of autophagy.PLoS One.2013 Jun 10;8(6):e64953. DMRSN2C RU https://www.ncbi.nlm.nih.gov/pubmed/23762270 DM0AOID DI DM0AOID DM0AOID DN MB-CART19.1 DM0AOID MI TTW640A DM0AOID MN B-lymphocyte surface antigen B4 (CD19) DM0AOID MT DTT DM0AOID MA CAR-T-Cell-Therapy DM0AOID RN ClinicalTrials.gov (NCT03321123) MB-CART19.1 in Patients With R/R ALL DM0AOID RU https://clinicaltrials.gov/ct2/show/NCT03321123 DMJVU7Y DI DMJVU7Y DMJVU7Y DN MBL-HCV1 DMJVU7Y MI TTDBG95 DMJVU7Y MN Hepatitis C virus Envelope glycoprotein E2 (HCV NS1) DMJVU7Y MT DTT DMJVU7Y MA Modulator DMJVU7Y RN Human monoclonal antibody MBL-HCV1 delays HCV viral rebound following liver transplantation: a randomized controlled study. Am J Transplant. 2013 Apr;13(4):1047-54. DMJVU7Y RU https://pubmed.ncbi.nlm.nih.gov/23356386 DMQMTO1 DI DMQMTO1 DMQMTO1 DN MBX-2044 DMQMTO1 MI TTZMAO3 DMQMTO1 MN Peroxisome proliferator-activated receptor gamma (PPAR-gamma) DMQMTO1 MT DTT DMQMTO1 MA Agonist DMQMTO1 RN MBX-102/JNJ39659100, a novel peroxisome proliferator-activated receptor-ligand with weak transactivation activity retains antidiabetic properties in the absence of weight gain and edema. Mol Endocrinol. 2009 Jul;23(7):975-88. DMQMTO1 RU https://pubmed.ncbi.nlm.nih.gov/19389808 DM0W3R7 DI DM0W3R7 DM0W3R7 DN MCLA-128 DM0W3R7 MI TT6EO5L DM0W3R7 MN Erbb2 tyrosine kinase receptor (HER2) DM0W3R7 MT DTT DM0W3R7 MA Antagonist DM0W3R7 RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DM0W3R7 RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DM0CL4I DI DM0CL4I DM0CL4I DN MCS-110 DM0CL4I MI TT731LW DM0CL4I MN Colony stimulating factor-1 receptor (CSF-1R) DM0CL4I MT DTT DM0CL4I MA Modulator DM0CL4I RN Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41. DM0CL4I RU https://www.ncbi.nlm.nih.gov/pubmed/15950434 DMX4U0B DI DMX4U0B DMX4U0B DN MCS-18 DMX4U0B MI TTY7ZHS DMX4U0B MN Toll-like receptor 2 (TLR2) DMX4U0B MT DTT DMX4U0B MA Modulator DMX4U0B RN The novel arthritis-drug substance MCS-18 attenuates the antibody production in vivo. Acta Microbiol Immunol Hung. 2008 Mar;55(1):15-31. DMX4U0B RU https://pubmed.ncbi.nlm.nih.gov/18507149 DMDR2SZ DI DMDR2SZ DMDR2SZ DN MCT-125 DMDR2SZ MI TTAWNKZ DMDR2SZ MN Norepinephrine transporter (NET) DMDR2SZ MT DTT DMDR2SZ MA Inhibitor DMDR2SZ RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 926). DMDR2SZ RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=926 DM5DSGJ DI DM5DSGJ DM5DSGJ DN MD-0727 DM5DSGJ MI TTNA5ZS DM5DSGJ MN Cholesterol absorption (Chole absorp) DM5DSGJ MT DTT DM5DSGJ MA Modulator DM5DSGJ RN Th-P16:297 Early clinical characterization of MD-0727, a novel cholesterol absorption inhibitor, in healthy subjects. Atherosclerosis Supplements Volume 7, Issue 3, 2006, Pages 558-559. DM5DSGJ RU http://www.sciencedirect.com/science/article/pii/S1567568806822555 DM9FXU7 DI DM9FXU7 DM9FXU7 DN MDL-27192 DM9FXU7 MI TT9IK2Z DM9FXU7 MN N-methyl-D-aspartate receptor (NMDAR) DM9FXU7 MT DTT DM9FXU7 MA Modulator DM9FXU7 RN Preclinical characterization of MDL 27,192 as a potential broad spectrum anticonvulsant agent with neuroprotective properties. Epilepsy Res. 1997 Apr;27(1):41-54. DM9FXU7 RU https://pubmed.ncbi.nlm.nih.gov/9169290 DMCK8SX DI DMCK8SX DMCK8SX DN MDX-1097 DMCK8SX MI TT1HM0R DMCK8SX MN Kappa myeloma antigen (KMA) DMCK8SX MT DTT DMCK8SX RN MDX-1097 induces antibody-dependent cellular cytotoxicity against kappa multiple myeloma cells and its activity is augmented by lenalidomide. Br J Haematol. 2015 May;169(3):333-43. DMCK8SX RU https://pubmed.ncbi.nlm.nih.gov/25653020 DM0EZWI DI DM0EZWI DM0EZWI DN MDX-1100 DM0EZWI MI TTQOVYA DM0EZWI MN C-X-C motif chemokine 10 (CXCL10) DM0EZWI MT DTT DM0EZWI RN A phase II, randomized, double-blind, placebo-controlled study evaluating the efficacy and safety of MDX-1100, a fully human anti-CXCL10 monoclonal antibody, in combination with methotrexate in patients with rheumatoid arthritis. Arthritis Rheum. 2012 Jun;64(6):1730-9. DM0EZWI RU https://pubmed.ncbi.nlm.nih.gov/22147649 DMKMSC4 DI DMKMSC4 DMKMSC4 DN MDX-1342 DMKMSC4 MI TTW640A DMKMSC4 MN B-lymphocyte surface antigen B4 (CD19) DMKMSC4 MT DTT DMKMSC4 RN A nonfucosylated human antibody to CD19 with potent B-cell depletive activity for therapy of B-cell malignancies. Cancer Immunol Immunother. 2010 Feb;59(2):257-65. DMKMSC4 RU https://pubmed.ncbi.nlm.nih.gov/19657637 DMO84TL DI DMO84TL DMO84TL DN ME-3407 DMO84TL MI TT18ETS DMO84TL MN Myosin light kinase (MYLK) DMO84TL MT DTT DMO84TL MA Inhibitor DMO84TL RN ME-3407, a new antiulcer agent, inhibits acid secretion by interfering with redistribution of H(+)-K(+)-ATPase. Am J Physiol. 1997 May;272(5 Pt 1):G1122-34. DMO84TL RU https://pubmed.ncbi.nlm.nih.gov/9176222 DMX9Y7V DI DMX9Y7V DMX9Y7V DN MEDETOMIDINE DMX9Y7V MI TTNGILX DMX9Y7V MN Adrenergic receptor alpha-1A (ADRA1A) DMX9Y7V MT DTT DMX9Y7V MA Inhibitor DMX9Y7V RN A structure-activity relationship study of benzylic modifications of 4-[1-(1-naphthyl)ethyl]-1H-imidazoles on alpha 1- and alpha 2-adrenergic recep... J Med Chem. 1994 Jul 22;37(15):2328-33. DMX9Y7V RU https://pubmed.ncbi.nlm.nih.gov/7914537 DMX9Y7V DI DMX9Y7V DMX9Y7V DN MEDETOMIDINE DMX9Y7V MI TTBRKXS DMX9Y7V MN Adrenergic receptor alpha-1B (ADRA1B) DMX9Y7V MT DTT DMX9Y7V MA Inhibitor DMX9Y7V RN A structure-activity relationship study of benzylic modifications of 4-[1-(1-naphthyl)ethyl]-1H-imidazoles on alpha 1- and alpha 2-adrenergic recep... J Med Chem. 1994 Jul 22;37(15):2328-33. DMX9Y7V RU https://pubmed.ncbi.nlm.nih.gov/7914537 DMX9Y7V DI DMX9Y7V DMX9Y7V DN MEDETOMIDINE DMX9Y7V MI TT34BHT DMX9Y7V MN Adrenergic receptor alpha-1D (ADRA1D) DMX9Y7V MT DTT DMX9Y7V MA Inhibitor DMX9Y7V RN A structure-activity relationship study of benzylic modifications of 4-[1-(1-naphthyl)ethyl]-1H-imidazoles on alpha 1- and alpha 2-adrenergic recep... J Med Chem. 1994 Jul 22;37(15):2328-33. DMX9Y7V RU https://pubmed.ncbi.nlm.nih.gov/7914537 DMX9Y7V DI DMX9Y7V DMX9Y7V DN MEDETOMIDINE DMX9Y7V MI TTWG9A4 DMX9Y7V MN Adrenergic receptor alpha-2A (ADRA2A) DMX9Y7V MT DTT DMX9Y7V MA Inhibitor DMX9Y7V RN A structure-activity relationship study of benzylic modifications of 4-[1-(1-naphthyl)ethyl]-1H-imidazoles on alpha 1- and alpha 2-adrenergic recep... J Med Chem. 1994 Jul 22;37(15):2328-33. DMX9Y7V RU https://pubmed.ncbi.nlm.nih.gov/7914537 DMX9Y7V DI DMX9Y7V DMX9Y7V DN MEDETOMIDINE DMX9Y7V MI TTWM4TY DMX9Y7V MN Adrenergic receptor alpha-2B (ADRA2B) DMX9Y7V MT DTT DMX9Y7V MA Inhibitor DMX9Y7V RN A structure-activity relationship study of benzylic modifications of 4-[1-(1-naphthyl)ethyl]-1H-imidazoles on alpha 1- and alpha 2-adrenergic recep... J Med Chem. 1994 Jul 22;37(15):2328-33. DMX9Y7V RU https://pubmed.ncbi.nlm.nih.gov/7914537 DMX9Y7V DI DMX9Y7V DMX9Y7V DN MEDETOMIDINE DMX9Y7V MI TT2NUT5 DMX9Y7V MN Adrenergic receptor alpha-2C (ADRA2C) DMX9Y7V MT DTT DMX9Y7V MA Inhibitor DMX9Y7V RN A structure-activity relationship study of benzylic modifications of 4-[1-(1-naphthyl)ethyl]-1H-imidazoles on alpha 1- and alpha 2-adrenergic recep... J Med Chem. 1994 Jul 22;37(15):2328-33. DMX9Y7V RU https://pubmed.ncbi.nlm.nih.gov/7914537 DMSV60C DI DMSV60C DMSV60C DN MEDI0382 DMSV60C MI TT0NUFM DMSV60C MN Glucagon (GCG) DMSV60C MT DTT DMSV60C MA Agonist DMSV60C RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMSV60C RU http://phrma-docs.phrma.org/files/dmfile/mid-diabetes-drug-list.pdf DMOXKIC DI DMOXKIC DMOXKIC DN MEDI3902 DMOXKIC MI TTLK9NJ DMOXKIC MN Pseudomonas PcrV protein type III (Pseudo pcrV) DMOXKIC MT DTT DMOXKIC RN A multifunctional bispecific antibody protects against Pseudomonas aeruginosa. Sci Transl Med. 2014 Nov 12;6(262):262ra155. DMOXKIC RU https://pubmed.ncbi.nlm.nih.gov/25391481 DMOXKIC DI DMOXKIC DMOXKIC DN MEDI3902 DMOXKIC MI TTTPDRC DMOXKIC MN Pseudomonas Psl exopolysaccharide (Pseudo pslG) DMOXKIC MT DTT DMOXKIC RN A multifunctional bispecific antibody protects against Pseudomonas aeruginosa. Sci Transl Med. 2014 Nov 12;6(262):262ra155. DMOXKIC RU https://pubmed.ncbi.nlm.nih.gov/25391481 DMDYVN8 DI DMDYVN8 DMDYVN8 DN MEDI-528 DMDYVN8 MI TT0JTFD DMDYVN8 MN Interleukin-9 (IL9) DMDYVN8 MT DTT DMDYVN8 MA Inhibitor DMDYVN8 RN Clinical pipeline report, company report or official report of AstraZeneca (2009). DMDYVN8 RU http://www.astrazeneca.com/_mshost3690701/content/resources/media/investors/AZN-Q2-2009/AZN-Q2-2009-Pipeline.pdf DMPKWR3 DI DMPKWR3 DMPKWR3 DN MEDI-546 DMPKWR3 MI TTSYFMA DMPKWR3 MN Interferon alpha/beta receptor 1 (IFNAR1) DMPKWR3 MT DTT DMPKWR3 MA Modulator DMPKWR3 RN Molecular basis for antagonistic activity of anifrolumab, an anti-interferon-alpha receptor 1 antibody. MAbs. 2015;7(2):428-39. DMPKWR3 RU https://pubmed.ncbi.nlm.nih.gov/25606664 DMBTVFE DI DMBTVFE DMBTVFE DN MEDI-551 DMBTVFE MI TTW640A DMBTVFE MN B-lymphocyte surface antigen B4 (CD19) DMBTVFE MT DTT DMBTVFE RN Clinical pipeline report, company report or official report of MedImmune (2011). DMBTVFE RU http://www.medimmune.com/research_pipeline.aspx DMI9WVM DI DMI9WVM DMI9WVM DN MEDI-575 DMI9WVM MI TT8FYO9 DMI9WVM MN Platelet-derived growth factor receptor alpha (PDGFRA) DMI9WVM MT DTT DMI9WVM RN Clinical pipeline report, company report or official report of MedImmune (2011). DMI9WVM RU http://www.medimmune.com/research_pipeline.aspx DMU4CS8 DI DMU4CS8 DMU4CS8 DN MEDI6012 DMU4CS8 MI TTGZ91P DMU4CS8 MN Lecithin-cholesterol acyltransferase (LCAT) DMU4CS8 MT DTT DMU4CS8 MA Modulator DMU4CS8 RN Familial lecithin-cholesterol acyltransferase (LCAT) deficiency; a differential of proteinuria. J Nephropathol. 2015 January; 4(1): 25-28. DMU4CS8 RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4316582/ DMGD1YP DI DMGD1YP DMGD1YP DN MEDI9929 DMGD1YP MI TTHMW3T DMGD1YP MN Thymic stromal lymphopoietin (TSLP) DMGD1YP MT DTT DMGD1YP MA Modulator DMGD1YP RN Human immunoglobulin G2Lambda monoclonal antibody directed against thymic stromal lymphopoietin (MEDI9929). European medicines agency science medicines health (EMEA-001613-PIP01-14). European Union. 2015. DMGD1YP RU http://www.ema.europa.eu/ema/index.jsp?curl=pages/medicines/pips/EMEA-001613-PIP01-14/pip_001268.jsp&mid=WC0b01ac058001d129 DM2C1YN DI DM2C1YN DM2C1YN DN MEGF0444A DM2C1YN MI TT7WD0H DM2C1YN MN Epidermal growth factor-like protein 7 (EGFL7) DM2C1YN MT DTT DM2C1YN MA Modulator DM2C1YN RN A first-in-human phase Ia open-label dose-escalation study of the safety, pharmacokinetics (PK), and pharmacodynamics (PD) of the humanized monoclonal antibody (huMAb) anti-EGFL7 (MEGF0444A) administered intravenously in patients with advanced solid tumors. J Clin Oncol (Meeting Abstracts) May 2011 vol.29 no.15_suppl 2614. DM2C1YN RU http://meeting.ascopubs.org/cgi/content/abstract/29/15_suppl/2614 DMHOF7T DI DMHOF7T DMHOF7T DN MEHD-7945A DMHOF7T MI TTGKNB4 DMHOF7T MN Epidermal growth factor receptor (EGFR) DMHOF7T MT DTT DMHOF7T MA Modulator DMHOF7T RN Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41. DMHOF7T RU https://www.ncbi.nlm.nih.gov/pubmed/15950434 DMHOF7T DI DMHOF7T DMHOF7T DN MEHD-7945A DMHOF7T MI TTDC8N2 DMHOF7T MN Erbb3 tyrosine kinase receptor (Erbb-3) DMHOF7T MT DTT DMHOF7T MA Modulator DMHOF7T RN Company report (Biooncology) DMHOF7T RU http://www.biooncology.com/pipeline-molecules/anti-her3 DMVJ6WS DI DMVJ6WS DMVJ6WS DN Melogliptin DMVJ6WS MI TTDIGC1 DMVJ6WS MN Dipeptidyl peptidase 4 (DPP-4) DMVJ6WS MT DTT DMVJ6WS MA Inhibitor DMVJ6WS RN Emerging drug candidates of dipeptidyl peptidase IV (DPP IV) inhibitor class for the treatment of Type 2 Diabetes. Curr Drug Targets. 2009 Jan;10(1):71-87. DMVJ6WS RU https://pubmed.ncbi.nlm.nih.gov/19149538 DMPNDYU DI DMPNDYU DMPNDYU DN MEM-3454 DMPNDYU MI TTLA931 DMPNDYU MN Neuronal acetylcholine receptor alpha-7 (CHRNA7) DMPNDYU MT DTT DMPNDYU MA Antagonist DMPNDYU RN The pipeline and future of drug development in schizophrenia. Mol Psychiatry. 2007 Oct;12(10):904-22. DMPNDYU RU https://pubmed.ncbi.nlm.nih.gov/17667958 DMUMCWS DI DMUMCWS DMUMCWS DN MEMP1972A DMUMCWS MI TTYJQTF DMUMCWS MN Immunoglobulin E (IgE) DMUMCWS MT DTT DMUMCWS RN International Nonproprietary Names for Pharmaceutical Substances (INN). WHO Drug Information, Vol. 25, No. 4, 2011 DMUMCWS RU http://www.who.int/medicines/publications/druginformation/innlists/Final_PL106.pdf DMIVR9K DI DMIVR9K DMIVR9K DN MER-3001 DMIVR9K MI TTZOPHG DMIVR9K MN Insulin (INS) DMIVR9K MT DTT DMIVR9K MA Modulator DMIVR9K RN Clinical pipeline report, company report or official report of Mercia Pharma Inc. DMIVR9K RU http://merciapharma.com/?page_id=81 DM89QXT DI DM89QXT DM89QXT DN MET409 DM89QXT MI TTS4UGC DM89QXT MN Farnesoid X-activated receptor (FXR) DM89QXT MT DTT DM89QXT MA Agonist DM89QXT RN Clinical pipeline report, company report or official report of Metacrine. DM89QXT RU https://www.metacrine.com/programs/ DMNST69 DI DMNST69 DMNST69 DN Metaiodobenzylguanidine I-131 DMNST69 MI TTAWNKZ DMNST69 MN Norepinephrine transporter (NET) DMNST69 MT DTT DMNST69 MA Modulator DMNST69 RN Imaging the norepinephrine transporter in neuroblastoma: a comparison of [18F]-MFBG and 123I-MIBG. Clin Cancer Res. 2014 Apr 15;20(8):2182-91. DMNST69 RU https://pubmed.ncbi.nlm.nih.gov/24573553 DMSZFTP DI DMSZFTP DMSZFTP DN Met-enkephalin DMSZFTP MI TT27RFC DMSZFTP MN Opioid receptor delta (OPRD1) DMSZFTP MT DTT DMSZFTP MA Agonist DMSZFTP RN Delta-opioid receptor agonists inhibit neuromuscular transmission in human colon. Eur J Pharmacol. 1994 Sep 1;262(1-2):33-9. DMSZFTP RU https://pubmed.ncbi.nlm.nih.gov/7813576 DMSZFTP DI DMSZFTP DMSZFTP DN Met-enkephalin DMSZFTP MI TTKWM86 DMSZFTP MN Opioid receptor mu (MOP) DMSZFTP MT DTT DMSZFTP MA Inhibitor DMSZFTP RN Further studies of tyrosine surrogates in opioid receptor peptide ligands. Bioorg Med Chem Lett. 2007 May 1;17(9):2656-60. DMSZFTP RU https://pubmed.ncbi.nlm.nih.gov/17350835 DMS7FRI DI DMS7FRI DMS7FRI DN Methanesulfonyl fluoride DMS7FRI MI TT1RS9F DMS7FRI MN Acetylcholinesterase (AChE) DMS7FRI MT DTT DMS7FRI MA Inhibitor DMS7FRI RN A randomized phase I study of methanesulfonyl fluoride, an irreversible cholinesterase inhibitor, for the treatment of Alzheimer's disease. Br J Clin Pharmacol. 2013 May;75(5):1231-9. DMS7FRI RU https://pubmed.ncbi.nlm.nih.gov/23116458 DMHSL87 DI DMHSL87 DMHSL87 DN Methoxyestradiol DMHSL87 MI TT6RVLG DMHSL87 MN Superoxide dismutase Cu-Zn (SOD Cu-Zn) DMHSL87 MT DTT DMHSL87 MA Inhibitor DMHSL87 RN Antitumor effects of photodynamic therapy are potentiated by 2-methoxyestradiol. A superoxide dismutase inhibitor. J Biol Chem. 2003 Jan 3;278(1):407-14. DMHSL87 RU https://pubmed.ncbi.nlm.nih.gov/12409296 DM5GQD7 DI DM5GQD7 DM5GQD7 DN Metoprine DM5GQD7 MI TT2B6EV DM5GQD7 MN Histamine N-methyltransferase (HNMT) DM5GQD7 MT DTT DM5GQD7 MA Inhibitor DM5GQD7 RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DM5GQD7 RU https://pubmed.ncbi.nlm.nih.gov/10592235 DM5GQD7 DI DM5GQD7 DM5GQD7 DN Metoprine DM5GQD7 MI TT9SL3Q DM5GQD7 MN Polypeptide deformylase (PDF) DM5GQD7 MT DTT DM5GQD7 MA Inhibitor DM5GQD7 RN Mutant Gly482 and Thr482 ABCG2 mediate high-level resistance to lipophilic antifolates. Cancer Chemother Pharmacol. 2006 Dec;58(6):826-34. DM5GQD7 RU https://pubmed.ncbi.nlm.nih.gov/16612649 DMIXT2Y DI DMIXT2Y DMIXT2Y DN MGAH22 DMIXT2Y MI TT6EO5L DMIXT2Y MN Erbb2 tyrosine kinase receptor (HER2) DMIXT2Y MT DTT DMIXT2Y MA Modulator DMIXT2Y RN Anti-tumor activity and toxicokinetics analysis of MGAH22, an anti-HER2 monoclonal antibody with enhanced Fcgamma receptor binding properties. Breast Cancer Res. 2011; 13(6): R123. DMIXT2Y RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3326565/ DMPBTVK DI DMPBTVK DMPBTVK DN MGB-BP-3 DMPBTVK MI TTS1W4A DMPBTVK MN Bacterial Deoxyribonucleic acid (Bact DNA) DMPBTVK MT DTT DMPBTVK MA Binder DMPBTVK RN Clinical pipeline report, company report or official report of MGB Biopharma. DMPBTVK RU https://www.mgb-biopharma.com/wp-content/uploads/SMi-MGB-Biopharma-Presentation.pdf DM726HX DI DM726HX DM726HX DN MGCD-0103 DM726HX MI TTBH0VX DM726HX MN Histone deacetylase (HDAC) DM726HX MT DTT DM726HX MA Inhibitor DM726HX RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DM726HX RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DM726HX DI DM726HX DM726HX DN MGCD-0103 DM726HX MI TT6R7JZ DM726HX MN Histone deacetylase 1 (HDAC1) DM726HX MT DTT DM726HX MA Inhibitor DM726HX RN Protein methyltransferases as a target class for drug discovery. Nat Rev Drug Discov. 2009 Sep;8(9):724-32. DM726HX RU https://pubmed.ncbi.nlm.nih.gov/19721445 DMRPCF2 DI DMRPCF2 DMRPCF2 DN MGCD265 DMRPCF2 MI TTU8W4S DMRPCF2 MN Protein kinase (PK) DMRPCF2 MT DTT DMRPCF2 MA Inhibitor DMRPCF2 RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMRPCF2 RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DMRPCF2 DI DMRPCF2 DMRPCF2 DN MGCD265 DMRPCF2 MI TTZPY6J DMRPCF2 MN Tyrosine-protein kinase UFO (AXL) DMRPCF2 MT DTT DMRPCF2 MA Modulator DMRPCF2 RN Company report (Mirati Therapeutics: formerly MethylGene) DMRPCF2 RU http://www.mirati.com/programs/mgcd265/ DMRSK2I DI DMRSK2I DMRSK2I DN MGCD290 DMRSK2I MI TTVO9RI DMRSK2I MN Fungal Probable histone deacetylase HOS2 (Fung HOS2) DMRSK2I MT DTT DMRSK2I MA Inhibitor DMRSK2I RN Activity of MGCD290, a Hos2 histone deacetylase inhibitor, in combination with azole antifungals against opportunistic fungal pathogens. J Clin Microbiol. 2009 Dec;47(12):3797-804. DMRSK2I RU https://pubmed.ncbi.nlm.nih.gov/19794038 DMNYPW7 DI DMNYPW7 DMNYPW7 DN MGI-114 DMNYPW7 MI DE4Q2OE DMNYPW7 MN Prostaglandin reductase 1 (PTGR1) DMNYPW7 MT DME DMNYPW7 MA Metabolism DMNYPW7 RN Up-regulation of human prostaglandin reductase 1 improves the efficacy of hydroxymethylacylfulvene, an antitumor chemotherapeutic agent. J Pharmacol Exp Ther. 2012 Nov;343(2):426-33. DMNYPW7 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=22895897 DM1HC9R DI DM1HC9R DM1HC9R DN MGL-3196 DM1HC9R MI TTGER3L DM1HC9R MN Thyroid hormone receptor beta (THRB) DM1HC9R MT DTT DM1HC9R MA Agonist DM1HC9R RN Lipid lowering in healthy volunteers treated with multiple doses of MGL-3196, a liver-targeted thyroid hormone receptor-beta agonist. Atherosclerosis. 2013 Oct;230(2):373-80. DM1HC9R RU https://pubmed.ncbi.nlm.nih.gov/24075770 DME5CSV DI DME5CSV DME5CSV DN Mibampator DME5CSV MI TTAN6JD DME5CSV MN Glutamate receptor AMPA (GRIA) DME5CSV MT DTT DME5CSV MA Agonist DME5CSV RN Mibampator (LY451395) Randomized Clinical Trial for Agitation/Aggression in Alzheimer's disease. Int Psychogeriatr. 2013 May; 25(5): 707-719. DME5CSV RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3938603/ DMGCRKY DI DMGCRKY DMGCRKY DN Midismase DMGCRKY MI TT6RVLG DMGCRKY MN Superoxide dismutase Cu-Zn (SOD Cu-Zn) DMGCRKY MT DTT DMGCRKY MA Modulator DMGCRKY RN A lecithinized superoxide dismutase (PC-SOD) improves ulcerative colitis DMGCRKY RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2659364 DMN45RI DI DMN45RI DMN45RI DN MIJ821 DMN45RI MI TTN9D8E DMN45RI MN Glutamate receptor ionotropic NMDA 2B (NMDAR2B) DMN45RI MT DTT DMN45RI MA Modulator DMN45RI RN Clinical pipeline report, company report or official report of Cadent Therapeutics. DMN45RI RU https://www.cipherbio.com/data-viz/organization/Cadent%2BTherapeutics/products DM50Z4U DI DM50Z4U DM50Z4U DN Milataxel DM50Z4U MI TTML2WA DM50Z4U MN Tubulin (TUB) DM50Z4U MT DTT DM50Z4U MA Inhibitor DM50Z4U RN J Clin Oncol 28, 2010 (suppl; abstr e13075). DM50Z4U RU http://meetinglibrary.asco.org/content/54296-74 DMSLIW6 DI DMSLIW6 DMSLIW6 DN MIN-117 DMSLIW6 MI TTSQIFT DMSLIW6 MN 5-HT 1A receptor (HTR1A) DMSLIW6 MT DTT DMSLIW6 MA Antagonist DMSLIW6 RN Company report (Minerva Neurosciences),MIN-101,Schizophrenia, 6 trials completed; Once a day formulation completed , Phase IIa completed; Phase IIb enrollment ongoing and expected to continue over the last 3 quarters of 2015. DMSLIW6 RU http://minervaneurosciences.com/ DMSLIW6 DI DMSLIW6 DMSLIW6 DN MIN-117 DMSLIW6 MI TT85JO3 DMSLIW6 MN 5-HT receptor (5HTR) DMSLIW6 MT DTT DMSLIW6 MA Antagonist DMSLIW6 RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMSLIW6 RU http://phrma-docs.phrma.org/files/dmfile/MID_Mental-Illness-2017-Drug-List_Final.pdf DMSLIW6 DI DMSLIW6 DMSLIW6 DN MIN-117 DMSLIW6 MI TTVBI8W DMSLIW6 MN Dopamine transporter (DAT) DMSLIW6 MT DTT DMSLIW6 MA Inhibitor DMSLIW6 RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMSLIW6 RU http://phrma-docs.phrma.org/files/dmfile/MID_Mental-Illness-2017-Drug-List_Final.pdf DMSLIW6 DI DMSLIW6 DMSLIW6 DN MIN-117 DMSLIW6 MI TT3ROYC DMSLIW6 MN Serotonin transporter (SERT) DMSLIW6 MT DTT DMSLIW6 MA Inhibitor DMSLIW6 RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMSLIW6 RU http://phrma-docs.phrma.org/files/dmfile/MID_Mental-Illness-2017-Drug-List_Final.pdf DMZFW8V DI DMZFW8V DMZFW8V DN MIN-202 DMZFW8V MI TT9N02I DMZFW8V MN Orexin receptor type 2 (HCRTR2) DMZFW8V MT DTT DMZFW8V MA Antagonist DMZFW8V RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMZFW8V RU http://phrma-docs.phrma.org/files/dmfile/MID_Mental-Illness-2017-Drug-List_Final.pdf DMWJMFZ DI DMWJMFZ DMWJMFZ DN Miravirsen DMWJMFZ MI TTP03CE DMWJMFZ MN Hepatitis C virus microRNA miR-122 (HCV MIR122) DMWJMFZ MT DTT DMWJMFZ MA Modulator DMWJMFZ RN Miravirsen (SPC3649) can inhibit the biogenesis of miR-122.Nucleic Acids Res.2014 Jan;42(1):609-21. DMWJMFZ RU https://www.ncbi.nlm.nih.gov/pubmed/24068553 DM7K4YR DI DM7K4YR DM7K4YR DN MIS-416 DM7K4YR MI TTYPUHA DM7K4YR MN Pattern recognition receptor NOD2 (NOD2) DM7K4YR MT DTT DM7K4YR MA Modulator DM7K4YR RN DOI: 10.1371/journal.pone.0087712 DM7K4YR RU http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0087712 DM7K4YR DI DM7K4YR DM7K4YR DN MIS-416 DM7K4YR MI TTSHG0T DM7K4YR MN Toll-like receptor 9 (TLR9) DM7K4YR MT DTT DM7K4YR MA Modulator DM7K4YR RN DOI: 10.1371/journal.pone.0087712 DM7K4YR RU http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0087712 DMOJ7QA DI DMOJ7QA DMOJ7QA DN Mitemcinal fumarate DMOJ7QA MI TT953CX DMOJ7QA MN Motilin receptor (MLNR) DMOJ7QA MT DTT DMOJ7QA MA Agonist DMOJ7QA RN Clinical pipeline report, company report or official report of Roche (2009). DMOJ7QA RU http://www.roche.com/research_and_development/pipeline/roche_pharma_pipeline.htm DMIRPSA DI DMIRPSA DMIRPSA DN Mitoglitazone DMIRPSA MI TTCBFJO DMIRPSA MN Insulin receptor (INSR) DMIRPSA MT DTT DMIRPSA MA Modulator DMIRPSA RN An evaluation of MSDC-0160, a prototype mTOT modulating insulin sensitizer, in patients with mild Alzheimer's disease. Curr Alzheimer Res. 2014;11(6):564-73. DMIRPSA RU https://pubmed.ncbi.nlm.nih.gov/24931567 DMIRPSA DI DMIRPSA DMIRPSA DN Mitoglitazone DMIRPSA MI TTSJH2W DMIRPSA MN Mitochondrial protein unspecific (MP) DMIRPSA MT DTT DMIRPSA MA Modulator DMIRPSA RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMIRPSA RU http://phrma-docs.phrma.org/files/dmfile/MID_Neurological-Disorders-Drug-List_2018.pdf DMKPZ0Q DI DMKPZ0Q DMKPZ0Q DN Mitoquinone DMKPZ0Q MI TTULV0X DMKPZ0Q MN Reactive oxygen species (ROS) DMKPZ0Q MT DTT DMKPZ0Q MA Inhibitor DMKPZ0Q RN Mitoquinone (MitoQ) Inhibits Platelet Activation Steps by Reducing ROS Levels. Int J Mol Sci. 2020 Aug 27;21(17):6192. DMKPZ0Q RU https://pubmed.ncbi.nlm.nih.gov/32867213 DM2NF6X DI DM2NF6X DM2NF6X DN MIV-210 DM2NF6X MI TTS5K1M DM2NF6X MN Hepatitis B virus Reverse transcriptase (HBV RT) DM2NF6X MT DTT DM2NF6X MA Modulator DM2NF6X RN Emerging antivirals for the treatment of hepatitis B DM2NF6X RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4069299 DMWFTRJ DI DMWFTRJ DMWFTRJ DN MK-0354 DMWFTRJ MI TTWNV8U DMWFTRJ MN Nicotinic acid receptor (HCAR2) DMWFTRJ MT DTT DMWFTRJ MA Inhibitor DMWFTRJ RN GPR109a agonists. Part 2: pyrazole-acids as agonists of the human orphan G-protein coupled receptor GPR109a. Bioorg Med Chem Lett. 2010 Aug 1;20(15):4472-4. DMWFTRJ RU https://pubmed.ncbi.nlm.nih.gov/20615702 DMLTAES DI DMLTAES DMLTAES DN MK-0752 DMLTAES MI TT9W8GU DMLTAES MN Gamma-secretase (GS) DMLTAES MT DTT DMLTAES MA Modulator DMLTAES RN Determination of the gamma-secretase inhibitor MK-0752 in human plasma by online extraction and electrospray tandem mass spectrometry (HTLC-ESI-MS/MS). J Chromatogr B Analyt Technol Biomed Life Sci. 2010 Sep 1;878(25):2348-52. DMLTAES RU https://pubmed.ncbi.nlm.nih.gov/20702149 DM2CJB4 DI DM2CJB4 DM2CJB4 DN MK-0773 DM2CJB4 MI TTS64P2 DM2CJB4 MN Androgen receptor (AR) DM2CJB4 MT DTT DM2CJB4 MA Modulator DM2CJB4 RN Discovery of the selective androgen receptor modulator MK-0773 using a rational development strategy based on differential transcriptional requirements for androgenic anabolism versus reproductive physiology. J Biol Chem. 2010 May 28;285(22):17054-64. DM2CJB4 RU https://pubmed.ncbi.nlm.nih.gov/20356837 DMRT8K4 DI DMRT8K4 DMRT8K4 DN MK-0812 DMRT8K4 MI TTFZYTO DMRT8K4 MN C-C chemokine receptor type 2 (CCR2) DMRT8K4 MT DTT DMRT8K4 MA Antagonist DMRT8K4 RN Assessment of chemokine receptor function on monocytes in whole blood: In vitro and ex vivo evaluations of a CCR2 antagonist. J Immunol Methods. 2010 Jan 31;352(1-2):101-10. DMRT8K4 RU https://pubmed.ncbi.nlm.nih.gov/19913021 DM0568C DI DM0568C DM0568C DN MK-0873 DM0568C MI TTZ97H5 DM0568C MN Phosphodiesterase 4A (PDE4A) DM0568C MT DTT DM0568C MA Inhibitor DM0568C RN MK-0873, a PDE4 inhibitor, does not influence the pharmacokinetics of theophylline in healthy male volunteers. Pulm Pharmacol Ther. 2008;21(3):573-7. DM0568C RU https://pubmed.ncbi.nlm.nih.gov/18321743 DM0568C DI DM0568C DM0568C DN MK-0873 DM0568C MI TTVIAT9 DM0568C MN Phosphodiesterase 4B (PDE4B) DM0568C MT DTT DM0568C MA Inhibitor DM0568C RN MK-0873, a PDE4 inhibitor, does not influence the pharmacokinetics of theophylline in healthy male volunteers. Pulm Pharmacol Ther. 2008;21(3):573-7. DM0568C RU https://pubmed.ncbi.nlm.nih.gov/18321743 DM0568C DI DM0568C DM0568C DN MK-0873 DM0568C MI TTSKMI8 DM0568C MN Phosphodiesterase 4D (PDE4D) DM0568C MT DTT DM0568C MA Inhibitor DM0568C RN MK-0873, a PDE4 inhibitor, does not influence the pharmacokinetics of theophylline in healthy male volunteers. Pulm Pharmacol Ther. 2008;21(3):573-7. DM0568C RU https://pubmed.ncbi.nlm.nih.gov/18321743 DM8ZTW7 DI DM8ZTW7 DM8ZTW7 DN MK-1029 DM8ZTW7 MI TTNVEIR DM8ZTW7 MN Prostaglandin D2 receptor (PTGDR) DM8ZTW7 MT DTT DM8ZTW7 MA Inhibitor DM8ZTW7 RN Update on the status of DP2 receptor antagonists; from proof of concept through clinical failures to promising new drugs. Expert Opin Investig Drugs. 2014 Jan;23(1):55-66. DM8ZTW7 RU https://pubmed.ncbi.nlm.nih.gov/24073896 DMEDITW DI DMEDITW DMEDITW DN MK-1454 DMEDITW MI TTT402Y DMEDITW MN Stimulator of interferon genes protein (TMEM173) DMEDITW MT DTT DMEDITW MA Agonist DMEDITW RN National Cancer Institute Drug Dictionary (drug name MK1454). DMEDITW RU https://www.cancer.gov/publications/dictionaries/cancer-drug/def/sting-agonist-mk-1454 DM3WDZ5 DI DM3WDZ5 DM3WDZ5 DN MK-1775 DM3WDZ5 MI TTJFOAL DM3WDZ5 MN Wee1-like protein kinase (WEE1) DM3WDZ5 MT DTT DM3WDZ5 MA Inhibitor DM3WDZ5 RN A novel c-Met inhibitor, MK8033, synergizes with carboplatin plus paclitaxel to inhibit ovarian cancer cell growth. Oncol Rep. 2013 May;29(5):2011-8. DM3WDZ5 RU https://pubmed.ncbi.nlm.nih.gov/23467907 DMVJB09 DI DMVJB09 DMVJB09 DN MK-1903 DMVJB09 MI TTWNV8U DMVJB09 MN Nicotinic acid receptor (HCAR2) DMVJB09 MT DTT DMVJB09 MA Agonist DMVJB09 RN Niacin lipid efficacy is independent of both the niacin receptor GPR109A and free fatty acid suppression. Sci Transl Med. 2012 Aug 22;4(148):148ra115. DMVJB09 RU https://pubmed.ncbi.nlm.nih.gov/22914621 DMT1OZ6 DI DMT1OZ6 DMT1OZ6 DN MK-2206 DMT1OZ6 MI TT0A1R8 DMT1OZ6 MN E2 ubiquitin-conjugating enzyme T (UBE2T) DMT1OZ6 MT DTT DMT1OZ6 MA Inhibitor DMT1OZ6 RN UBE2T promotes nasopharyngeal carcinoma cell proliferation, invasion, and metastasis by activating the AKT/GSK3/-catenin pathway.Oncotarget. 2016 Mar 22;7(12):15161-72. DMT1OZ6 RU https://pubmed.ncbi.nlm.nih.gov/26943030 DMT1OZ6 DI DMT1OZ6 DMT1OZ6 DN MK-2206 DMT1OZ6 MI TTAZ05C DMT1OZ6 MN RAC-gamma serine/threonine-protein kinase (AKT3) DMT1OZ6 MT DTT DMT1OZ6 MA Modulator DMT1OZ6 RN First-in-man clinical trial of the oral pan-AKT inhibitor MK-2206 in patients with advanced solid tumors.J Clin Oncol.2011 Dec 10;29(35):4688-95. DMT1OZ6 RU https://www.ncbi.nlm.nih.gov/pubmed/22025163 DM1M57I DI DM1M57I DM1M57I DN MK-2578 DM1M57I MI TTQG4NR DM1M57I MN Erythropoietin (EPO) DM1M57I MT DTT DM1M57I MA Agonist DM1M57I RN Merck ditches biogeneric. Nat Biotechnol. 2010 Jul;28(7):636. DM1M57I RU https://pubmed.ncbi.nlm.nih.gov/20622817 DM6OLGC DI DM6OLGC DM6OLGC DN MK-3207 DM6OLGC MI TTY6O0Q DM6OLGC MN Calcitonin gene-related peptide receptor (CGRPR) DM6OLGC MT DTT DM6OLGC MA Antagonist DM6OLGC RN Pharmacological properties of MK-3207, a potent and orally active calcitonin gene-related peptide receptor antagonist. J Pharmacol Exp Ther. 2010 Apr;333(1):152-60. DM6OLGC RU https://pubmed.ncbi.nlm.nih.gov/20065019 DM347TQ DI DM347TQ DM347TQ DN MK-3697 DM347TQ MI TT9N02I DM347TQ MN Orexin receptor type 2 (HCRTR2) DM347TQ MT DTT DM347TQ MA Modulator DM347TQ RN Discovery of MK-3697: a selective orexin 2 receptor antagonist (2-SORA) for the treatment of insomnia. Bioorg Med Chem Lett. 2014 Oct 15;24(20):4884-90. DM347TQ RU https://pubmed.ncbi.nlm.nih.gov/25248679 DMSPWX6 DI DMSPWX6 DMSPWX6 DN MK-5172 DMSPWX6 MI TT5FNQT DMSPWX6 MN Human immunodeficiency virus Protease (HIV PR) DMSPWX6 MT DTT DMSPWX6 MA Inhibitor DMSPWX6 RN Clinical pipeline report, company report or official report of Merck (2011). DMSPWX6 RU http://www.merck.com/index.html DMHTIGU DI DMHTIGU DMHTIGU DN MK-5442 DMHTIGU MI TTBUYHA DMHTIGU MN Extracellular calcium-sensing receptor (CASR) DMHTIGU MT DTT DMHTIGU MA Modulator DMHTIGU RN Antagonist for calcium-sensing receptor. JTT-305/MK-5442. Clin Calcium. 2011 Jan;21(1):89-93. DMHTIGU RU https://pubmed.ncbi.nlm.nih.gov/21187599 DMLMV0O DI DMLMV0O DMLMV0O DN MK-7655 DMLMV0O MI TTHI19T DMLMV0O MN Staphylococcus Beta-lactamase (Stap-coc blaZ) DMLMV0O MT DTT DMLMV0O MA Inhibitor DMLMV0O RN Discovery of MK-7655, a beta-lactamase inhibitor for combination with Primaxin . Bioorg Med Chem Lett. 2014 Feb 1;24(3):780-5. DMLMV0O RU https://pubmed.ncbi.nlm.nih.gov/24433862 DMG6KXB DI DMG6KXB DMG6KXB DN MK-8245 DMG6KXB MI TT6RIOV DMG6KXB MN Acyl-CoA desaturase (SCD) DMG6KXB MT DTT DMG6KXB MA Inhibitor DMG6KXB RN Development of a liver-targeted stearoyl-CoA desaturase (SCD) inhibitor (MK-8245) to establish a therapeutic window for the treatment of diabetes and dyslipidemia. J Med Chem. 2011 Jul 28;54(14):5082-96. DMG6KXB RU https://pubmed.ncbi.nlm.nih.gov/21661758 DMD6E5W DI DMD6E5W DMD6E5W DN MK-8342 DMD6E5W MI TTUV8G9 DMD6E5W MN Progesterone receptor (PGR) DMD6E5W MT DTT DMD6E5W MA Agonist DMD6E5W RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 627). DMD6E5W RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=627 DMVNAYE DI DMVNAYE DMVNAYE DN MK-8521 DMVNAYE MI TT0NUFM DMVNAYE MN Glucagon (GCG) DMVNAYE MT DTT DMVNAYE MA Co-agonist DMVNAYE RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMVNAYE RU http://phrma-docs.phrma.org/files/dmfile/mid-diabetes-drug-list.pdf DMVNAYE DI DMVNAYE DMVNAYE DN MK-8521 DMVNAYE MI TT9O6WS DMVNAYE MN Glucagon receptor (GCGR) DMVNAYE MT DTT DMVNAYE MA Co-agonist DMVNAYE RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMVNAYE RU http://phrma-docs.phrma.org/files/dmfile/mid-diabetes-drug-list.pdf DMQHS6B DI DMQHS6B DMQHS6B DN MK-866 DMQHS6B MI TT2J34L DMQHS6B MN Arachidonate 5-lipoxygenase (5-LOX) DMQHS6B MT DTT DMQHS6B MA Modulator DMQHS6B RN Inhibition of leukotriene synthesis with MK-886 prevents a rise in blood pressure and reduces noradrenaline-evoked contraction in L-NAME-treated rats DMQHS6B RU https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1574003 DMXKOW6 DI DMXKOW6 DMXKOW6 DN MKC-1106-MT DMXKOW6 MI TT362RB DMXKOW6 MN MART-1 melanoma antigen (MLANA) DMXKOW6 MT DTT DMXKOW6 MA Modulator DMXKOW6 RN Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41. DMXKOW6 RU https://www.ncbi.nlm.nih.gov/pubmed/15950434 DMXKOW6 DI DMXKOW6 DMXKOW6 DN MKC-1106-MT DMXKOW6 MI TTULVH8 DMXKOW6 MN Tyrosinase (TYR) DMXKOW6 MT DTT DMXKOW6 MA Modulator DMXKOW6 RN Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41. DMXKOW6 RU https://www.ncbi.nlm.nih.gov/pubmed/15950434 DM3I71U DI DM3I71U DM3I71U DN MKT-077 DM3I71U MI TTMTPG3 DM3I71U MN Mortalin (HSPA9) DM3I71U MT DTT DM3I71U MA Modulator DM3I71U RN Selective toxicity of MKT-077 to cancer cells is mediated by its binding to the hsp70 family protein mot-2 and reactivation of p53 function. Cancer Res. 2000 Dec 15;60(24):6818-21. DM3I71U RU https://pubmed.ncbi.nlm.nih.gov/11156371 DMQSO4L DI DMQSO4L DMQSO4L DN ML-04 DMQSO4L MI TT2O4W9 DMQSO4L MN Luteinizing hormone receptor (LHCGR) DMQSO4L MT DTT DMQSO4L MA Modulator DMQSO4L RN Evaluation of radiolabeled ML04, a putative irreversible inhibitor of epidermal growth factor receptor, as a bioprobe for PET imaging of EGFR-overexpressing tumors. Nucl Med Biol. 2007 Jan;34(1):55-70. DMQSO4L RU https://pubmed.ncbi.nlm.nih.gov/17210462 DMI4E9K DI DMI4E9K DMI4E9K DN MLN0264 DMI4E9K MI TTLDPRG DMI4E9K MN Guanylyl cyclase C (GUCY2C) DMI4E9K MT DTT DMI4E9K MA Modulator DMI4E9K RN J Clin Oncol 31, 2013 (suppl; abstr TPS3646). DMI4E9K RU http://meetinglibrary.asco.org/content/111779-132 DM24SOL DI DM24SOL DM24SOL DN MLN1202 DM24SOL MI TTFZYTO DM24SOL MN C-C chemokine receptor type 2 (CCR2) DM24SOL MT DTT DM24SOL MA Antagonist DM24SOL RN Emerging drugs for the treatment of chronic obstructive pulmonary disease. Expert Opin Emerg Drugs. 2006 May;11(2):275-91. DM24SOL RU https://pubmed.ncbi.nlm.nih.gov/16634702 DM24SOL DI DM24SOL DM24SOL DN MLN1202 DM24SOL MI TTUPB12 DM24SOL MN Measles virus Fusion glycoprotein (MeV F) DM24SOL MT DTT DM24SOL MA Inhibitor DM24SOL RN Emerging drugs for respiratory syncytial virus infection. Expert Opin Emerg Drugs. 2009 Jun;14(2):207-17. DM24SOL RU https://pubmed.ncbi.nlm.nih.gov/19453286 DMBR8NF DI DMBR8NF DMBR8NF DN MLN2480 DMBR8NF MI TT0EOB8 DMBR8NF MN B-Raf messenger RNA (BRAF mRNA) DMBR8NF MT DTT DMBR8NF MA Inhibitor DMBR8NF RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1943). DMBR8NF RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1943 DMBR8NF DI DMBR8NF DMBR8NF DN MLN2480 DMBR8NF MI TTAN5W2 DMBR8NF MN Raf messenger RNA (Raf mRNA) DMBR8NF MT DTT DMBR8NF MA Inhibitor DMBR8NF RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2184). DMBR8NF RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2184 DMBR8NF DI DMBR8NF DMBR8NF DN MLN2480 DMBR8NF MI TTQ9K3Y DMBR8NF MN Serine/threonine-protein kinase Raf (RAF) DMBR8NF MT DTT DMBR8NF MA Inhibitor DMBR8NF RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMBR8NF RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DMJHVZC DI DMJHVZC DMJHVZC DN MLN-591RL DMJHVZC MI TT9G4N0 DMJHVZC MN Glutamate carboxypeptidase II (GCPII) DMJHVZC MT DTT DMJHVZC RN Indium 111-labeled J591 anti-PSMA antibody for vascular targeted imaging in progressive solid tumors. EJNMMI Res. 2015 Apr 29;5:28. DMJHVZC RU https://pubmed.ncbi.nlm.nih.gov/25984435 DMXJWNS DI DMXJWNS DMXJWNS DN MM-093 DMXJWNS MI TTCFEA1 DMXJWNS MN Alpha-fetoprotein (AFP) DMXJWNS MT DTT DMXJWNS MA Modulator DMXJWNS RN MM-093, a recombinant human alpha-fetoprotein for the potential treatment of rheumatoid arthritis and other autoimmune diseases. Curr Opin Mol Ther. 2007 Dec;9(6):603-10. DMXJWNS RU https://pubmed.ncbi.nlm.nih.gov/18041671 DMO7MBS DI DMO7MBS DMO7MBS DN MM-111 DMO7MBS MI TT6EO5L DMO7MBS MN Erbb2 tyrosine kinase receptor (HER2) DMO7MBS MT DTT DMO7MBS MA Modulator DMO7MBS RN Bispecific antibodies rise again. Nat Rev Drug Discov. 2014 Nov;13(11):799-801. DMO7MBS RU https://www.ncbi.nlm.nih.gov/pubmed/25359367 DMDJRU1 DI DMDJRU1 DMDJRU1 DN MM-121 DMDJRU1 MI TTDC8N2 DMDJRU1 MN Erbb3 tyrosine kinase receptor (Erbb-3) DMDJRU1 MT DTT DMDJRU1 MA Modulator DMDJRU1 RN Company report (Merrimack) DMDJRU1 RU http://investors.merrimack.com/releasedetail.cfm?releaseid=897168 DM2RJ4D DI DM2RJ4D DM2RJ4D DN MM-141 DM2RJ4D MI TTDC8N2 DM2RJ4D MN Erbb3 tyrosine kinase receptor (Erbb-3) DM2RJ4D MT DTT DM2RJ4D MA Modulator DM2RJ4D RN MM-141, an IGF-IR- and ErbB3-directed bispecific antibody, overcomes network adaptations that limit activity of IGF-IR inhibitors. Mol Cancer Ther. 2014 Feb;13(2):410-25. DM2RJ4D RU https://pubmed.ncbi.nlm.nih.gov/24282274 DM2RJ4D DI DM2RJ4D DM2RJ4D DN MM-141 DM2RJ4D MI TTHRID2 DM2RJ4D MN Insulin-like growth factor I receptor (IGF1R) DM2RJ4D MT DTT DM2RJ4D MA Modulator DM2RJ4D RN MM-141, an IGF-IR- and ErbB3-directed bispecific antibody, overcomes network adaptations that limit activity of IGF-IR inhibitors. Mol Cancer Ther. 2014 Feb;13(2):410-25. DM2RJ4D RU https://pubmed.ncbi.nlm.nih.gov/24282274 DM2RJ4D DI DM2RJ4D DM2RJ4D DN MM-141 DM2RJ4D MI TTCJG29 DM2RJ4D MN Serine/threonine-protein kinase mTOR (mTOR) DM2RJ4D MT DTT DM2RJ4D MA Inhibitor DM2RJ4D RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DM2RJ4D RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DM6VPIO DI DM6VPIO DM6VPIO DN MM36 DM6VPIO MI TT0JLSD DM6VPIO MN Multidrug resistance protein (MDR) DM6VPIO MT DTT DM6VPIO MA Inhibitor DM6VPIO RN Thiazolides: a new class of antiviral drugs. Expert Opin Drug Metab Toxicol. 2009 Jun;5(6):667-74. DM6VPIO RU https://pubmed.ncbi.nlm.nih.gov/19442032 DMBX2RE DI DMBX2RE DMBX2RE DN MN-221 DMBX2RE MI TT2CJVK DMBX2RE MN Adrenergic receptor beta-2 (ADRB2) DMBX2RE MT DTT DMBX2RE MA Agonist DMBX2RE RN Investigation of beta(2)-adrenoceptor subtype selectivity and organ specificity for bedoradrine (KUR-1246), a novel tocolytic beta-adrenergic receptor stimulant. J Obstet Gynaecol Res. 2009 Jun;35(3):405-13. DMBX2RE RU https://pubmed.ncbi.nlm.nih.gov/19527375 DMUGN4B DI DMUGN4B DMUGN4B DN MN-305 DMUGN4B MI TTSQIFT DMUGN4B MN 5-HT 1A receptor (HTR1A) DMUGN4B MT DTT DMUGN4B MA Agonist DMUGN4B RN Novel drugs and therapeutic targets for severe mood disorders. Neuropsychopharmacology. 2008 Aug;33(9):2080-92. DMUGN4B RU https://pubmed.ncbi.nlm.nih.gov/18172433 DMQA3MV DI DMQA3MV DMQA3MV DN MNX-100 DMQA3MV MI TT2MN5K DMQA3MV MN Phosphorylated protein kinase B (pAKT) DMQA3MV MT DTT DMQA3MV MA Modulator DMQA3MV RN Clinical pipeline report, company report or official report of MetronomX. DMQA3MV RU http://www.metronomxgroup.com/mnx-100.php DMGK1JE DI DMGK1JE DMGK1JE DN MORAb-004 DMGK1JE MI TTYJWT7 DMGK1JE MN Endosialin (CD248) DMGK1JE MT DTT DMGK1JE MA Modulator DMGK1JE RN A first-in-human phase I study of MORAb-004, a monoclonal antibody to endosialin in patients with advanced solid tumors. Clin Cancer Res. 2015 Mar 15;21(6):1281-8. DMGK1JE RU https://pubmed.ncbi.nlm.nih.gov/25398449 DMCXNIP DI DMCXNIP DMCXNIP DN MORAb-009 DMCXNIP MI TT4RXME DMCXNIP MN Mesothelin (MSLN) DMCXNIP MT DTT DMCXNIP RN Phase II clinical trial of amatuximab, a chimeric antimesothelin antibody with pemetrexed and cisplatin in advanced unresectable pleural mesothelioma. Clin Cancer Res. 2014 Dec 1;20(23):5927-36. DMCXNIP RU https://pubmed.ncbi.nlm.nih.gov/25231400 DMYCITZ DI DMYCITZ DMYCITZ DN MP-101 DMYCITZ MI TTXJ47W DMYCITZ MN Metabotropic glutamate receptor 2 (mGluR2) DMYCITZ MT DTT DMYCITZ MA Agonist DMYCITZ RN ClinicalTrials.gov (NCT03044249) A Study of MP-101 in Dementia-Related Psychosis and/or Agitation and Aggression. U.S. National Institutes of Health. DMYCITZ RU https://clinicaltrials.gov/ct2/show/NCT03044249 DMYCITZ DI DMYCITZ DMYCITZ DN MP-101 DMYCITZ MI TT8A9EF DMYCITZ MN Metabotropic glutamate receptor 3 (mGluR3) DMYCITZ MT DTT DMYCITZ MA Agonist DMYCITZ RN ClinicalTrials.gov (NCT03044249) A Study of MP-101 in Dementia-Related Psychosis and/or Agitation and Aggression. U.S. National Institutes of Health. DMYCITZ RU https://clinicaltrials.gov/ct2/show/NCT03044249 DMELUAK DI DMELUAK DMELUAK DN MP470 DMELUAK MI TT8FYO9 DMELUAK MN Platelet-derived growth factor receptor alpha (PDGFRA) DMELUAK MT DTT DMELUAK MA Modulator DMELUAK RN Phase 1B study of amuvatinib in combination with five standard cancer therapies in adults with advanced solid tumors. Cancer Chemother Pharmacol. 2014 Jul;74(1):195-204. DMELUAK RU https://pubmed.ncbi.nlm.nih.gov/24849582 DMELUAK DI DMELUAK DMELUAK DN MP470 DMELUAK MI TTX41N9 DMELUAK MN Tyrosine-protein kinase Kit (KIT) DMELUAK MT DTT DMELUAK MA Modulator DMELUAK RN Phase 1B study of amuvatinib in combination with five standard cancer therapies in adults with advanced solid tumors. Cancer Chemother Pharmacol. 2014 Jul;74(1):195-204. DMELUAK RU https://pubmed.ncbi.nlm.nih.gov/24849582 DMMRYEK DI DMMRYEK DMMRYEK DN MPSK3169A DMMRYEK MI TTNIZ2B DMMRYEK MN PCSK9 messenger RNA (PCSK9 mRNA) DMMRYEK MT DTT DMMRYEK MA Modulator DMMRYEK RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2388). DMMRYEK RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2388 DMQR23W DI DMQR23W DMQR23W DN MRE-0094 DMQR23W MI TTM2AOE DMQR23W MN Adenosine A2a receptor (ADORA2A) DMQR23W MT DTT DMQR23W MA Agonist DMQR23W RN Emerging drugs for diabetic foot ulcers. Expert Opin Emerg Drugs. 2006 Nov;11(4):709-24. DMQR23W RU https://pubmed.ncbi.nlm.nih.gov/17064227 DMJK8L1 DI DMJK8L1 DMJK8L1 DN MRG002 DMJK8L1 MI TT6EO5L DMJK8L1 MN Erbb2 tyrosine kinase receptor (HER2) DMJK8L1 MT DTT DMJK8L1 RN ClinicalTrials.gov (NCT04839510) A Study of MRG002 in the Treatment of HER2-positive Unresectable Locally Advanced or Metastatic Urothelium Cancer. U.S. National Institutes of Health. DMJK8L1 RU https://clinicaltrials.gov/ct2/show/NCT04839510 DM9M5WV DI DM9M5WV DM9M5WV DN MRG-201 DM9M5WV MI TTK982E DM9M5WV MN Collagen (CO) DM9M5WV MT DTT DM9M5WV MA Modulator DM9M5WV RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DM9M5WV RU http://phrma-docs.phrma.org/files/dmfile/medicines-in-development-drug-list-autoimmune-diseases.pdf DM9M5WV DI DM9M5WV DM9M5WV DN MRG-201 DM9M5WV MI TT1GNRQ DM9M5WV MN microRNA hsa-miR-155 (MIR155) DM9M5WV MT DTT DM9M5WV MA Modulator DM9M5WV RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DM9M5WV RU http://phrma-docs.phrma.org/files/dmfile/medicines-in-development-drug-list-autoimmune-diseases.pdf DMQZWYE DI DMQZWYE DMQZWYE DN MRX-4 DMQZWYE MI TT9V5JH DMQZWYE MN Phospholipase A2 (PLA2G1B) DMQZWYE MT DTT DMQZWYE MA Inhibitor DMQZWYE RN Phospholipase A2, group IVA (cytosolic, calcium-dependent) (PLA2G4A). SciBX 1(41); doi:10.1038/scibx.2008.999. Nov. 13 2008 DMQZWYE RU http://www.nature.com/scibx/journal/v1/n41/full/scibx.2008.999.html DMLVQKF DI DMLVQKF DMLVQKF DN MRX-6 DMLVQKF MI TT9V5JH DMLVQKF MN Phospholipase A2 (PLA2G1B) DMLVQKF MT DTT DMLVQKF MA Inhibitor DMLVQKF RN A novel treatment of contact dermatitis by topical application of phospholipase A2 inhibitor: a double-blind placebo-controlled pilot study. Int J Immunopathol Pharmacol. 2007 Jan-Mar;20(1):191-5. DMLVQKF RU https://pubmed.ncbi.nlm.nih.gov/17346444 DMH1DYU DI DMH1DYU DMH1DYU DN MSC1936369B DMH1DYU MI DE4LYSA DMH1DYU MN Cytochrome P450 3A4 (CYP3A4) DMH1DYU MT DME DMH1DYU MA Metabolism DMH1DYU RN Metabolism of the MEK1/2 inhibitor pimasertib involves a novel conjugation with phosphoethanolamine in patients with solid tumors. Drug Metab Dispos. 2017 Feb;45(2):174-182. DMH1DYU RU https://www.ncbi.nlm.nih.gov/pubmed/?term=27934635 DMH1DYU DI DMH1DYU DMH1DYU DN MSC1936369B DMH1DYU MI TTROQ37 DMH1DYU MN MAPK/ERK kinase kinase (MAP3K) DMH1DYU MT DTT DMH1DYU MA Modulator DMH1DYU RN Antitumor activity of pimasertib, a selective MEK 1/2 inhibitor, in combination with PI3K/mTOR inhibitors or with multi-targeted kinase inhibitors in pimasertib-resistant human lung and colorectal cancer cells. Int J Cancer. 2013 Nov;133(9):2089-101. DMH1DYU RU https://pubmed.ncbi.nlm.nih.gov/23629727 DMH1DYU DI DMH1DYU DMH1DYU DN MSC1936369B DMH1DYU MI DEGTFWK DMH1DYU MN Mephenytoin 4-hydroxylase (CYP2C19) DMH1DYU MT DME DMH1DYU MA Metabolism DMH1DYU RN Metabolism of the MEK1/2 inhibitor pimasertib involves a novel conjugation with phosphoethanolamine in patients with solid tumors. Drug Metab Dispos. 2017 Feb;45(2):174-182. DMH1DYU RU https://www.ncbi.nlm.nih.gov/pubmed/?term=27934635 DMGUI51 DI DMGUI51 DMGUI51 DN MSDC-0602 DMGUI51 MI TTCBFJO DMGUI51 MN Insulin receptor (INSR) DMGUI51 MT DTT DMGUI51 MA Modulator DMGUI51 RN Insulin resistance and metabolic derangements in obese mice are ameliorated by a novel peroxisome proliferator-activated receptor gamma-sparing thiazolidinedione. J Biol Chem. 2012 Jul 6;287(28):23537-48. DMGUI51 RU https://pubmed.ncbi.nlm.nih.gov/22621923 DMUM370 DI DMUM370 DMUM370 DN MSH-1001 DMUM370 MI TT1VOHK DMUM370 MN Potassium channel unspecific (KC) DMUM370 MT DTT DMUM370 MA Opener DMUM370 RN KR-31378, a potassium-channel opener, induces the protection of retinal ganglion cells in rat retinal ischemic models. J Pharmacol Sci. 2009 Apr;109(4):511-7. DMUM370 RU https://pubmed.ncbi.nlm.nih.gov/19372634 DMSE9TH DI DMSE9TH DMSE9TH DN MT-1303 DMSE9TH MI TT9JZCK DMSE9TH MN Sphingosine-1-phosphate receptor 1 (S1PR1) DMSE9TH MT DTT DMSE9TH MA Modulator DMSE9TH RN Sphingosine 1-Phosphate Receptor Modulators in Multiple Sclerosis. CNS Drugs. 2015 Jul;29(7):565-75. DMSE9TH RU https://pubmed.ncbi.nlm.nih.gov/26239599 DM7I0MT DI DM7I0MT DM7I0MT DN MT203 DM7I0MT MI TTNYZG2 DM7I0MT MN Granulocyte-macrophage colony-stimulating factor (CSF2) DM7I0MT MT DTT DM7I0MT MA Modulator DM7I0MT RN GM-CSF as a target in inflammatory/autoimmune disease: current evidence and future therapeutic potential. Expert Rev Clin Immunol. 2015 Apr;11(4):457-65. DM7I0MT RU https://pubmed.ncbi.nlm.nih.gov/25748625 DMCNL7Z DI DMCNL7Z DMCNL7Z DN MT-3724 DMCNL7Z MI TTUE541 DMCNL7Z MN Leukocyte surface antigen Leu-16 (CD20) DMCNL7Z MT DTT DMCNL7Z MA Inhibitor DMCNL7Z RN Clinical pipeline report, company report or official report of Molecular Templates. DMCNL7Z RU https://www.mtem.com/pipeline/mt-3724 DMXSZA4 DI DMXSZA4 DMXSZA4 DN MT-3995 DMXSZA4 MI TT26PHO DMXSZA4 MN Mineralocorticoid receptor (MR) DMXSZA4 MT DTT DMXSZA4 MA Antagonist DMXSZA4 RN Nonsteroidal antagonists of the mineralocorticoid receptor. Curr Opin Nephrol Hypertens. 2015 Sep;24(5):417-24. DMXSZA4 RU https://pubmed.ncbi.nlm.nih.gov/26083526 DM7VG8L DI DM7VG8L DM7VG8L DN MTC-896 DM7VG8L MI TT6QAJ3 DM7VG8L MN Melanocortin receptor 5 (MC5R) DM7VG8L MT DTT DM7VG8L MA Antagonist DM7VG8L RN Clinical pipeline report, company report or official report of Avarx. DM7VG8L RU http://www.avarx.com/AvaRx/SubDomains/Company231/Listings/231/Public.Listing.display.html DMT0K4F DI DMT0K4F DMT0K4F DN MTR105 DMT0K4F MI TTCM4B3 DMT0K4F MN Nitric-oxide synthase endothelial (NOS3) DMT0K4F MT DTT DMT0K4F MA Inhibitor DMT0K4F RN Nitric oxide synthase inhibitor (MTR-105) during open-heart surgery. A pilot double-blind placebo-controlled study of hemodynamic effects and safety. Cardiology. 2008;111(3):181-7. DMT0K4F RU https://pubmed.ncbi.nlm.nih.gov/18434722 DML7N4B DI DML7N4B DML7N4B DN MUC1-Poly-ICLC DML7N4B MI TTBHFYQ DML7N4B MN Mucin-1 (MUC1) DML7N4B MT DTT DML7N4B RN Early in vivo signaling profiles in MUC1-specific CD4+ T cells responding to two different MUC1-targeting vaccines in two different microenvironments. Oncoimmunology. 2013 Mar 1;2(3):e23429. DML7N4B RU https://pubmed.ncbi.nlm.nih.gov/23802084 DMN68ZL DI DMN68ZL DMN68ZL DN Multi-epitope tyrosinase/gp100 vaccine DMN68ZL MI TT8MK59 DMN68ZL MN Melanocytes lineage-specific antigen GP100 (PMEL) DMN68ZL MT DTT DMN68ZL RN ClinicalTrials.gov (NCT00003362) Vaccine Therapy Plus Immune Adjuvants in Treating Patients With Advanced Melanoma. U.S. National Institutes of Health. DMN68ZL RU https://clinicaltrials.gov/ct2/show/NCT00003362 DMN68ZL DI DMN68ZL DMN68ZL DN Multi-epitope tyrosinase/gp100 vaccine DMN68ZL MI TTULVH8 DMN68ZL MN Tyrosinase (TYR) DMN68ZL MT DTT DMN68ZL RN ClinicalTrials.gov (NCT00003362) Vaccine Therapy Plus Immune Adjuvants in Treating Patients With Advanced Melanoma. U.S. National Institutes of Health. DMN68ZL RU https://clinicaltrials.gov/ct2/show/NCT00003362 DMM6KZR DI DMM6KZR DMM6KZR DN Mutant ras vaccine DMM6KZR MI TTW2R9X DMM6KZR MN GTPase NRas (NRAS) DMM6KZR MT DTT DMM6KZR RN The immunological and clinical effects of mutated ras peptide vaccine in combination with IL-2, GM-CSF, or both in patients with solid tumors. J Transl Med. 2014 Feb 24;12:55. DMM6KZR RU https://pubmed.ncbi.nlm.nih.gov/24565030 DMKDN1C DI DMKDN1C DMKDN1C DN MVA-85A DMKDN1C MI TTZYJ8U DMKDN1C MN Mycobacterium Antigen complex 85A (MycB fbpA) DMKDN1C MT DTT DMKDN1C RN MVA-85A, a novel candidate booster vaccine for the prevention of tuberculosis in children and adults. Curr Opin Mol Ther. 2010 Feb;12(1):124-34. DMKDN1C RU https://pubmed.ncbi.nlm.nih.gov/20140824 DMDN6FO DI DMDN6FO DMDN6FO DN MVI-816 DMDN6FO MI TTBRZQS DMDN6FO MN Prostatic acid phosphatase (ACPP) DMDN6FO MT DTT DMDN6FO MA Modulator DMDN6FO RN Company report (Madisonvaccine) DMDN6FO RU http://www.madisonvaccinesinc.com/Home/News DM25VY8 DI DM25VY8 DM25VY8 DN Mydicar DM25VY8 MI TTE6THL DM25VY8 MN Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 (ATP2A2) DM25VY8 MT DTT DM25VY8 MA Modulator DM25VY8 RN Clinical pipeline report, company report or official report of Celladon. DM25VY8 RU http://www.celladon.com/mydicar/ DMO1XUK DI DMO1XUK DMO1XUK DN Myeloma cancer vaccine DMO1XUK MI TT6MP2Z DMO1XUK MN GMCSFR-alpha (CSF2RA) DMO1XUK MT DTT DMO1XUK RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1707). DMO1XUK RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1707 DM9BREJ DI DM9BREJ DM9BREJ DN MYK-491 DM9BREJ MI TTITSMB DM9BREJ MN Myosin (MYO) DM9BREJ MT DTT DM9BREJ MA Activator DM9BREJ RN Effects of danicamtiv, a novel cardiac myosin activator, in heart failure with reduced ejection fraction: experimental data and clinical results from a phase 2a trial. Eur J Heart Fail. 2020 Sep;22(9):1649-1658. DM9BREJ RU https://pubmed.ncbi.nlm.nih.gov/32558989 DMQKSGI DI DMQKSGI DMQKSGI DN Myo-inositol DMQKSGI MI TTE4KHA DMQKSGI MN Amyloid beta A4 protein (APP) DMQKSGI MT DTT DMQKSGI MA Inhibitor DMQKSGI RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMQKSGI RU http://phrma-docs.phrma.org/files/dmfile/MID_Mental-Illness-2017-Drug-List_Final.pdf DMQKSGI DI DMQKSGI DMQKSGI DN Myo-inositol DMQKSGI MI DE0J45Y DMQKSGI MN Inositol dehydrogenase (idh) DMQKSGI MT DME DMQKSGI MA Metabolism DMQKSGI RN Purification, crystallization and room-temperature X-ray diffraction of inositol dehydrogenase LcIDH2 from Lactobacillus casei BL23. Acta Crystallogr F Struct Biol Commun. 2014 Jul;70(Pt 7):979-83. DMQKSGI RU https://pubmed.ncbi.nlm.nih.gov/25005103 DMQKSGI DI DMQKSGI DMQKSGI DN Myo-inositol DMQKSGI MI DEDUGWF DMQKSGI MN Inositol dehydrogenase (idh) DMQKSGI MT DME DMQKSGI MA Metabolism DMQKSGI RN Purification, crystallization and room-temperature X-ray diffraction of inositol dehydrogenase LcIDH2 from Lactobacillus casei BL23. Acta Crystallogr F Struct Biol Commun. 2014 Jul;70(Pt 7):979-83. DMQKSGI RU https://pubmed.ncbi.nlm.nih.gov/25005103 DMQKSGI DI DMQKSGI DMQKSGI DN Myo-inositol DMQKSGI MI TTI0TCK DMQKSGI MN Mycobacterium CDP-diacylglycerol-inositol phosphatidyltransferase (MycB pssA) DMQKSGI MT DTT DMQKSGI MA Inhibitor DMQKSGI RN Phosphatidylinositol synthesis in mycobacteria. Biochim Biophys Acta. 1999 Jan 4;1436(3):437-50. DMQKSGI RU https://pubmed.ncbi.nlm.nih.gov/9989274 DMQKSGI DI DMQKSGI DMQKSGI DN Myo-inositol DMQKSGI MI DT8ACN1 DMQKSGI MN Sodium/myo-inositol cotransporter (SLC5A3) DMQKSGI MT DTP DMQKSGI MA Substrate DMQKSGI RN Identification of a novel Na+/myo-inositol cotransporter. J Biol Chem. 2002 Sep 20;277(38):35219-24. DMQKSGI RU http://www.ncbi.nlm.nih.gov/pubmed/12133831 DMQKSGI DI DMQKSGI DMQKSGI DN Myo-inositol DMQKSGI MI DT2CAPQ DMQKSGI MN Sodium/myo-inositol cotransporter 2 (SLC5A11) DMQKSGI MT DTP DMQKSGI MA Substrate DMQKSGI RN The sodium/glucose cotransport family SLC5. Pflugers Arch. 2004 Feb;447(5):510-8. DMQKSGI RU http://www.ncbi.nlm.nih.gov/pubmed/12748858 DMUK6HC DI DMUK6HC DMUK6HC DN N-5984 DMUK6HC MI TTMXGCW DMUK6HC MN Adrenergic receptor beta-3 (ADRB3) DMUK6HC MT DTT DMUK6HC MA Agonist DMUK6HC RN Emerging drugs for obesity: linking novel biological mechanisms to pharmaceutical pipelines. Expert Opin Emerg Drugs. 2005 Aug;10(3):643-60. DMUK6HC RU https://pubmed.ncbi.nlm.nih.gov/16083333 DMN7EUO DI DMN7EUO DMN7EUO DN N6022 DMN7EUO MI TTVG0SN DMN7EUO MN S-nitrosoglutathione reductase (CBR1) DMN7EUO MT DTT DMN7EUO MA Inhibitor DMN7EUO RN Mechanism of inhibition for N6022, a first-in-class drug targeting S-nitrosoglutathione reductase. Biochemistry. 2012 Mar 13;51(10):2157-68. DMN7EUO RU https://pubmed.ncbi.nlm.nih.gov/22335564 DM7P0WR DI DM7P0WR DM7P0WR DN NAI-acne DM7P0WR MI TTYQIFM DM7P0WR MN Staphylococcus Elongation factor Tu (Stap-coc tuf) DM7P0WR MT DTT DM7P0WR MA Modulator DM7P0WR RN Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800031008) DM7P0WR RU http://adisinsight.springer.com/drugs/800031008 DMSWUNX DI DMSWUNX DMSWUNX DN Naratuximab emtansine DMSWUNX MI TTFCW29 DMSWUNX MN Leukocyte antigen CD37 (CD37) DMSWUNX MT DTT DMSWUNX MA Inhibitor DMSWUNX RN Clinical pipeline report, company report or official report of Debiopharm. DMSWUNX RU https://www.debiopharm.com/drug-development/pipeline/debio-1562/ DMD0E8U DI DMD0E8U DMD0E8U DN Naveglitazar DMD0E8U MI TTJ584C DMD0E8U MN Peroxisome proliferator-activated receptor alpha (PPARA) DMD0E8U MT DTT DMD0E8U MA Modulator DMD0E8U RN The disposition and metabolism of naveglitazar, a peroxisome proliferator-activated receptor alpha-gamma dual, gamma-dominant agonist in mice, rats... Drug Metab Dispos. 2007 Jan;35(1):51-61. DMD0E8U RU https://pubmed.ncbi.nlm.nih.gov/17012539 DMD0E8U DI DMD0E8U DMD0E8U DN Naveglitazar DMD0E8U MI TTZMAO3 DMD0E8U MN Peroxisome proliferator-activated receptor gamma (PPAR-gamma) DMD0E8U MT DTT DMD0E8U MA Modulator DMD0E8U RN The disposition and metabolism of naveglitazar, a peroxisome proliferator-activated receptor alpha-gamma dual, gamma-dominant agonist in mice, rats... Drug Metab Dispos. 2007 Jan;35(1):51-61. DMD0E8U RU https://pubmed.ncbi.nlm.nih.gov/17012539 DMH9JFZ DI DMH9JFZ DMH9JFZ DN NBI-5788 DMH9JFZ MI TT2RY5P DMH9JFZ MN Myelin basic protein (MBP) DMH9JFZ MT DTT DMH9JFZ MA Binder DMH9JFZ RN NBI-5788, an altered MBP83-99 peptide, induces a T-helper 2-like immune response in multiple sclerosis patients. Ann Neurol. 2000 Nov;48(5):758-65. DMH9JFZ RU https://pubmed.ncbi.nlm.nih.gov/11079539 DMT6O2E DI DMT6O2E DMT6O2E DN NC318 DMT6O2E MI TTBSZPF DMT6O2E MN Sialic acid-binding immunoglobulin-like lectin 15 (SIGLEC15) DMT6O2E MT DTT DMT6O2E MA Inhibitor DMT6O2E RN Clinical pipeline report, company report or official report of NextCure. DMT6O2E RU http://www.nextcure.com/pipeline/ DMVQKB3 DI DMVQKB3 DMVQKB3 DN NCI-C50000 DMVQKB3 MI DE4LYSA DMVQKB3 MN Cytochrome P450 3A4 (CYP3A4) DMVQKB3 MT DME DMVQKB3 MA Metabolism DMVQKB3 RN Integrated analysis on the physicochemical properties of dihydropyridine calcium channel blockers in grapefruit juice interactions. Curr Pharm Biotechnol. 2012 Jul;13(9):1705-17. DMVQKB3 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=22039822 DM4W28K DI DM4W28K DM4W28K DN NCX 1022 DM4W28K MI TTK0943 DM4W28K MN Prostaglandin G/H synthase (COX) DM4W28K MT DTT DM4W28K MA Modulator DM4W28K RN Anti-inflammatory effects of nitric oxide-releasing hydrocortisone NCX 1022, in a murine model of contact dermatitis. Br J Pharmacol. 2004 Nov;143(5):618-25. DM4W28K RU https://pubmed.ncbi.nlm.nih.gov/15313880 DM2YIZH DI DM2YIZH DM2YIZH DN NCX-1000 DM2YIZH MI TTZY5KP DM2YIZH MN Caspase (CASP) DM2YIZH MT DTT DM2YIZH MA Modulator DM2YIZH RN Liver delivery of NO by NCX-1000 protects against acute liver failure and mitochondrial dysfunction induced by APAP in mice. Br J Pharmacol. 2004 Sep;143(1):33-42. DM2YIZH RU https://pubmed.ncbi.nlm.nih.gov/15345658 DMOX1CU DI DMOX1CU DMOX1CU DN NCX-4016 DMOX1CU MI TTK0943 DMOX1CU MN Prostaglandin G/H synthase (COX) DMOX1CU MT DTT DMOX1CU MA Inhibitor DMOX1CU RN Emerging drugs in peripheral arterial disease. Expert Opin Emerg Drugs. 2006 Mar;11(1):75-90. DMOX1CU RU https://pubmed.ncbi.nlm.nih.gov/16503827 DM6S83X DI DM6S83X DM6S83X DN NDDP DM6S83X MI TTUTN1I DM6S83X MN Human Deoxyribonucleic acid (hDNA) DM6S83X MT DTT DM6S83X MA Binder DM6S83X RN Cell death and DNA fragmentation induced by liposomal platinum(II) complex, L-NDDP in A2780 and A2780/PDD cells. Anticancer Res. 1994 Mar-Apr;14(2A):421-6. DM6S83X RU https://pubmed.ncbi.nlm.nih.gov/8017841 DMVIRN3 DI DMVIRN3 DMVIRN3 DN N-DESMETHYLCLOZAPINE DMVIRN3 MI TTZ9SOR DMVIRN3 MN Muscarinic acetylcholine receptor M1 (CHRM1) DMVIRN3 MT DTT DMVIRN3 MA Modulator DMVIRN3 RN N-desmethylclozapine, a major metabolite of clozapine, increases cortical acetylcholine and dopamine release in vivo via stimulation of M1 muscarin... Neuropsychopharmacology. 2005 Nov;30(11):1986-95. DMVIRN3 RU https://www.ncbi.nlm.nih.gov/pubmed/15900318 DMUPZFO DI DMUPZFO DMUPZFO DN Neihulizumab DMUPZFO MI TTS5K8U DMUPZFO MN P-selectin glycoprotein ligand 1 (SELPLG) DMUPZFO MT DTT DMUPZFO MA Inhibitor DMUPZFO RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMUPZFO RU http://phrma-docs.phrma.org/files/dmfile/medicines-in-development-drug-list-autoimmune-diseases.pdf DMSVWI7 DI DMSVWI7 DMSVWI7 DN Neladenoson bialanate DMSVWI7 MI TT92EIB DMSVWI7 MN ADORA1 messenger RNA (ADORA1 mRNA) DMSVWI7 MT DTT DMSVWI7 MA Agonist DMSVWI7 RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMSVWI7 RU http://phrma-docs.phrma.org/files/dmfile/2018_Heart-Disease-and-Stroke_MID-Drug-List.pdf DM4LKFO DI DM4LKFO DM4LKFO DN NELOTANSERIN DM4LKFO MI TTJQOD7 DM4LKFO MN 5-HT 2A receptor (HTR2A) DM4LKFO MT DTT DM4LKFO MA Modulator DM4LKFO RN Nelotanserin, a novel selective human 5-hydroxytryptamine2A inverse agonist for the treatment of insomnia.J Pharmacol Exp Ther.2010 Jan;332(1):281-90. DM4LKFO RU https://www.ncbi.nlm.nih.gov/pubmed/19841476 DMNM9DZ DI DMNM9DZ DMNM9DZ DN Nepicastat oral DMNM9DZ MI TTYIP79 DMNM9DZ MN Dopamine beta hydroxylase (DBH) DMNM9DZ MT DTT DMNM9DZ MA Inhibitor DMNM9DZ RN Catecholamine modulatory effects of nepicastat (RS-25560-197), a novel, potent and selective inhibitor of dopamine-beta-hydroxylase. Br J Pharmacol. 1997 Aug;121(8):1803-9. DMNM9DZ RU https://pubmed.ncbi.nlm.nih.gov/9283721 DM3ORVD DI DM3ORVD DM3ORVD DN Neramexane DM3ORVD MI TT9IK2Z DM3ORVD MN N-methyl-D-aspartate receptor (NMDAR) DM3ORVD MT DTT DM3ORVD MA Antagonist DM3ORVD RN Emerging analgesics in cancer pain management. Expert Opin Emerg Drugs. 2005 Feb;10(1):151-71. DM3ORVD RU https://pubmed.ncbi.nlm.nih.gov/15757410 DMBJ3GL DI DMBJ3GL DMBJ3GL DN Nerenone DMBJ3GL MI TT26PHO DMBJ3GL MN Mineralocorticoid receptor (MR) DMBJ3GL MT DTT DMBJ3GL MA Antagonist DMBJ3GL RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 626). DMBJ3GL RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=626 DM8H7OA DI DM8H7OA DM8H7OA DN Netoglitazone DM8H7OA MI DE4LYSA DM8H7OA MN Cytochrome P450 3A4 (CYP3A4) DM8H7OA MT DME DM8H7OA MA Metabolism DM8H7OA RN Effects of gemfibrozil, itraconazole, and their combination on the pharmacokinetics of pioglitazone. Clin Pharmacol Ther. 2005 May;77(5):404-14. DM8H7OA RU https://www.ncbi.nlm.nih.gov/pubmed/?term=15900286 DM8H7OA DI DM8H7OA DM8H7OA DN Netoglitazone DM8H7OA MI TTZMAO3 DM8H7OA MN Peroxisome proliferator-activated receptor gamma (PPAR-gamma) DM8H7OA MT DTT DM8H7OA MA Modulator DM8H7OA RN Netoglitazone is a PPAR-gamma ligand with selective effects on bone and fat. Bone. 2006 Jan;38(1):74-84. DM8H7OA RU https://www.ncbi.nlm.nih.gov/pubmed/16137931 DMOZW4C DI DMOZW4C DMOZW4C DN Neublastin DMOZW4C MI TT63XRS DMOZW4C MN GDNF receptor alpha-3 (GFRA3) DMOZW4C MT DTT DMOZW4C MA Modulator DMOZW4C RN First-In-Human, Double-Blind, Placebo-Controlled, Randomized, Dose-Escalation Study of BG00010, a Glial Cell Line-Derived Neurotrophic Factor Family Member, in Subjects with Unilateral Sciatica. PLoSOne. 2015 May 11;10(5):e0125034. DMOZW4C RU https://pubmed.ncbi.nlm.nih.gov/25962165 DMIQDFW DI DMIQDFW DMIQDFW DN Neu-P11 DMIQDFW MI TTSQIFT DMIQDFW MN 5-HT 1A receptor (HTR1A) DMIQDFW MT DTT DMIQDFW MA Agonist DMIQDFW RN Clinical pipeline report, company report or official report of Neurim Pharmaceuticals. DMIQDFW RU http://www.neurim.com/products/ DMIQDFW DI DMIQDFW DMIQDFW DN Neu-P11 DMIQDFW MI TT6MSOK DMIQDFW MN 5-HT 1D receptor (HTR1D) DMIQDFW MT DTT DMIQDFW MA Agonist DMIQDFW RN Clinical pipeline report, company report or official report of Neurim Pharmaceuticals. DMIQDFW RU http://www.neurim.com/products/ DMIQDFW DI DMIQDFW DMIQDFW DN Neu-P11 DMIQDFW MI TT0WAIE DMIQDFW MN Melatonin receptor type 1A (MTNR1A) DMIQDFW MT DTT DMIQDFW MA Agonist DMIQDFW RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 288). DMIQDFW RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=288 DMINQP1 DI DMINQP1 DMINQP1 DN NEUROPEPTIDE-Y DMINQP1 MI TTRK9JT DMINQP1 MN Neuropeptide Y receptor type 1 (NPY1R) DMINQP1 MT DTT DMINQP1 MA Inhibitor DMINQP1 RN 5-OHKF and NorKA, depsipeptides from a Hawaiian collection of Bryopsis pennata: binding properties for NorKA to the human neuropeptide Y Y1 receptor. J Nat Prod. 2009 Dec;72(12):2172-6. DMINQP1 RU https://pubmed.ncbi.nlm.nih.gov/19916528 DMINQP1 DI DMINQP1 DMINQP1 DN NEUROPEPTIDE-Y DMINQP1 MI TTJ6WK9 DMINQP1 MN Neuropeptide Y receptor type 2 (NPY2R) DMINQP1 MT DTT DMINQP1 MA Inhibitor DMINQP1 RN cis-4-(Piperazin-1-yl)-5,6,7a,8,9,10,11,11a-octahydrobenzofuro[2,3-h]quinazolin-2-amine (A-987306), a new histamine H4R antagonist that blocks pain... J Med Chem. 2008 Nov 27;51(22):7094-8. DMINQP1 RU https://pubmed.ncbi.nlm.nih.gov/18983139 DML5S71 DI DML5S71 DML5S71 DN Nexopamil DML5S71 MI TTYSN63 DML5S71 MN 5-HT 2 receptor (5HT2R) DML5S71 MT DTT DML5S71 MA Modulator DML5S71 RN Inhibition by the combined Ca2+ and 5-HT2 receptor antagonist nexopamil (LU 49938) of intracoronary thrombus formation in a canine model of arterial stenosis and intimal damage. J Cardiovasc Pharmacol. 1993 Nov;22(5):687-94. DML5S71 RU https://pubmed.ncbi.nlm.nih.gov/7506319 DML5S71 DI DML5S71 DML5S71 DN Nexopamil DML5S71 MI TT5HONZ DML5S71 MN Calcium channel unspecific (CaC) DML5S71 MT DTT DML5S71 MA Blocker DML5S71 RN Inhibition by the combined Ca2+ and 5-HT2 receptor antagonist nexopamil (LU 49938) of intracoronary thrombus formation in a canine model of arterial stenosis and intimal damage. J Cardiovasc Pharmacol. 1993 Nov;22(5):687-94. DML5S71 RU https://pubmed.ncbi.nlm.nih.gov/7506319 DMJKBAY DI DMJKBAY DMJKBAY DN NGX-267 DMJKBAY MI TTZ9SOR DMJKBAY MN Muscarinic acetylcholine receptor M1 (CHRM1) DMJKBAY MT DTT DMJKBAY MA Agonist DMJKBAY RN Pharmacological comparison of muscarinic ligands: historical versus more recent muscarinic M1-preferring receptor agonists. Eur J Pharmacol. 2009 Mar 1;605(1-3):53-6. DMJKBAY RU https://pubmed.ncbi.nlm.nih.gov/19168056 DMDY01J DI DMDY01J DMDY01J DN NHS-IL2-LT DMDY01J MI TTUTN1I DMDY01J MN Human Deoxyribonucleic acid (hDNA) DMDY01J MT DTT DMDY01J MA Modulator DMDY01J RN Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41. DMDY01J RU https://www.ncbi.nlm.nih.gov/pubmed/15950434 DMRQUH4 DI DMRQUH4 DMRQUH4 DN NI-0801 DMRQUH4 MI TTQOVYA DMRQUH4 MN C-X-C motif chemokine 10 (CXCL10) DMRQUH4 MT DTT DMRQUH4 RN Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800029267) DMRQUH4 RU http://adisinsight.springer.com/drugs/800029267 DMKLJMI DI DMKLJMI DMKLJMI DN NIC-002 DMKLJMI MI TTJSZTB DMKLJMI MN Nicotinic acetylcholine receptor (nAChR) DMKLJMI MT DTT DMKLJMI RN Therapeutic advances in the treatment of nicotine addiction: present and future. Ther Adv Chronic Dis. 2010 May; 1(3): 95-106. DMKLJMI RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3513862/ DMG7XOC DI DMG7XOC DMG7XOC DN NIC5-15 DMG7XOC MI TTE4KHA DMG7XOC MN Amyloid beta A4 protein (APP) DMG7XOC MT DTT DMG7XOC MA Inhibitor DMG7XOC RN Combating neurodegenerative disease with chemical probes and model systems. Nat Chem Biol. 2014 Nov;10(11):911-20. DMG7XOC RU https://pubmed.ncbi.nlm.nih.gov/25325702 DM21Z68 DI DM21Z68 DM21Z68 DN Nimacimab DM21Z68 MI TT6OEDT DM21Z68 MN Cannabinoid receptor 1 (CB1) DM21Z68 MT DTT DM21Z68 MA Antagonist DM21Z68 RN Clinical pipeline report, company report or official report of Bird Rock Bio. DM21Z68 RU http://www.birdrockbio.com/our-pipeline/nimacimab/ DMPER4A DI DMPER4A DMPER4A DN NIR178 DMPER4A MI TTSLI08 DMPER4A MN Adenosine receptor (ADOR) DMPER4A MT DTT DMPER4A MA Antagonist DMPER4A RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMPER4A RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DM81SDB DI DM81SDB DM81SDB DN Niravoline DM81SDB MI TTQW87Y DM81SDB MN Opioid receptor kappa (OPRK1) DM81SDB MT DTT DM81SDB MA Modulator DM81SDB RN Effect of niravoline (RU51599), a kappa-opioid receptor agonist, on tumour-origin brain oedema. Acta Neurochir (Wien). 1999;141(7):771-8. DM81SDB RU https://www.ncbi.nlm.nih.gov/pubmed/10481790 DM8LBYT DI DM8LBYT DM8LBYT DN NIS793 DM8LBYT MI TTO3HT7 DM8LBYT MN Transforming growth factor beta (TGFB) DM8LBYT MT DTT DM8LBYT MA Inhibitor DM8LBYT RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DM8LBYT RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DMQHBSX DI DMQHBSX DMQHBSX DN NITD609 DMQHBSX MI TTJFY5U DMQHBSX MN Adenosine A3 receptor (ADORA3) DMQHBSX MT DTT DMQHBSX MA Inhibitor DMQHBSX RN Spiroindolones, a potent compound class for the treatment of malaria. Science. 2010 Sep 3;329(5996):1175-80. DMQHBSX RU https://pubmed.ncbi.nlm.nih.gov/20813948 DMQHBSX DI DMQHBSX DMQHBSX DN NITD609 DMQHBSX MI TTQ6VDM DMQHBSX MN Voltage-gated potassium channel Kv11.1 (KCNH2) DMQHBSX MT DTT DMQHBSX MA Inhibitor DMQHBSX RN Spiroindolones, a potent compound class for the treatment of malaria. Science. 2010 Sep 3;329(5996):1175-80. DMQHBSX RU https://pubmed.ncbi.nlm.nih.gov/20813948 DMAOUZV DI DMAOUZV DMAOUZV DN Nivatrotamab DMAOUZV MI TT80ARU DMAOUZV MN Ganglioside GD2 (GD2) DMAOUZV MT DTT DMAOUZV MA Inhibitor DMAOUZV RN Clinical pipeline report, company report or official report of Y-mAbs Therapeutics. DMAOUZV RU https://ymabs.com/research-development/pipeline/ DMAOUZV DI DMAOUZV DMAOUZV DN Nivatrotamab DMAOUZV MI TTUN7MC DMAOUZV MN T-cell surface glycoprotein CD3 (CD3) DMAOUZV MT DTT DMAOUZV MA Inhibitor DMAOUZV RN Clinical pipeline report, company report or official report of Y-mAbs Therapeutics. DMAOUZV RU https://ymabs.com/research-development/pipeline/ DMUX8JZ DI DMUX8JZ DMUX8JZ DN Nivocasan DMUX8JZ MI TTCQIBE DMUX8JZ MN Caspase-1 (CASP1) DMUX8JZ MT DTT DMUX8JZ MA Modulator DMUX8JZ RN Combined effects of an antioxidant and caspase inhibitor on the reversal of hepatic fibrosis in rats. Apoptosis. 2013 Dec;18(12):1481-91. DMUX8JZ RU https://pubmed.ncbi.nlm.nih.gov/24045874 DMTVGMZ DI DMTVGMZ DMTVGMZ DN NKP 608 DMTVGMZ MI TTZPO1L DMTVGMZ MN Substance-P receptor (TACR1) DMTVGMZ MT DTT DMTVGMZ MA Antagonist DMTVGMZ RN Neurokinin-1-receptor antagonism decreases anxiety and emotional arousal circuit response to noxious visceral distension in women with irritable bowel syndrome: a pilot study. Aliment Pharmacol Ther.2012 Feb;35(3):360-7. DMTVGMZ RU https://pubmed.ncbi.nlm.nih.gov/22221140 DMKD5ZO DI DMKD5ZO DMKD5ZO DN NN-8226 DMKD5ZO MI TTNZMY2 DMKD5ZO MN Interleukin-20 (IL20) DMKD5ZO MT DTT DMKD5ZO RN Handbook of Therapeutic Antibodies. 2014. 1. Page(995). DMKD5ZO RU https://books.google.com.hk/books?id=svHsBQAAQBAJ&pg=PA995&lpg=PA995&dq=NN-8828++++++ANTI&source=bl&ots=OSgek3Ucgf&sig=8iYcf4GKsCAvCCC1QHsKqxZK3YQ&hl=zh-CN&sa=X&ved=0CEwQ6AEwBmoVChMIyrS7qtXGyAIVA0COCh20lgxt#v=onepage&q=NN-8828%20%20%20%20%20%20ANTI&f=false DM3IEHP DI DM3IEHP DM3IEHP DN NN8555 DM3IEHP MI TTLRN4A DM3IEHP MN NKG2 D activating NK receptor (KLRK1) DM3IEHP MT DTT DM3IEHP MA Antagonist DM3IEHP RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DM3IEHP RU http://phrma-docs.phrma.org/files/dmfile/medicines-in-development-drug-list-autoimmune-diseases.pdf DMCFPBE DI DMCFPBE DMCFPBE DN NN8765 DMCFPBE MI TTC4IMS DMCFPBE MN NKG2-A/B-activating NK receptor (NKG2A) DMCFPBE MT DTT DMCFPBE MA Modulator DMCFPBE RN Handbook of Therapeutic Antibodies. 2014. 1. Page(1098). DMCFPBE RU https://books.google.com.hk/books?id=svHsBQAAQBAJ&pg=PA2173&lpg=PA2173&dq=%22NN-8765%22+++drug&source=bl&ots=OSgek3Ubee&sig=uPqJzQ0sfWmrddc5W83GKlUI4JQ&hl=zh-CN&sa=X&ved=0CBoQ6AEwAGoVChMI3cTx8NTGyAIVTgWOCh29iQZt DMDTNOS DI DMDTNOS DMDTNOS DN NNC-0123-0000-0338 DMDTNOS MI TTZOPHG DMDTNOS MN Insulin (INS) DMDTNOS MT DTT DMDTNOS MA Modulator DMDTNOS RN ClinicalTrials.gov (NCT01334034) Safety of NNC 0123-0000-0338 in Healthy Subjects. U.S. National Institutes of Health. DMDTNOS RU https://clinicaltrials.gov/ct2/show/NCT01334034 DMU3KOH DI DMU3KOH DMU3KOH DN NNC-0151-0000-0000 DMU3KOH MI TTKANGO DMU3KOH MN Complement C5 (CO5) DMU3KOH MT DTT DMU3KOH RN Complement-targeted therapeutics. Nat Biotechnol. 2007 Nov;25(11):1265-75. DMU3KOH RU https://pubmed.ncbi.nlm.nih.gov/17989689 DMPZ97S DI DMPZ97S DMPZ97S DN NNZ-2566 DMPZ97S MI TT9RTYG DMPZ97S MN Neuropeptide receptor (NPR) DMPZ97S MT DTT DMPZ97S MA Modulator DMPZ97S RN NNZ-2566 treatment inhibits neuroinflammation and pro-inflammatory cytokine expression induced by experimental penetrating ballistic-like brain injury in rats. J Neuroinflammation. 2009 Aug 5;6:19. DMPZ97S RU https://pubmed.ncbi.nlm.nih.gov/19656406 DME8IFQ DI DME8IFQ DME8IFQ DN Noberastine DME8IFQ MI TTTIBOJ DME8IFQ MN Histamine H1 receptor (H1R) DME8IFQ MT DTT DME8IFQ MA Antagonist DME8IFQ RN A double-blind placebo controlled dose response study of noberastine on histamine induced weal and flare. Eur J Clin Pharmacol. 1991;40(1):83-5. DME8IFQ RU https://pubmed.ncbi.nlm.nih.gov/1676366 DMEHOI1 DI DMEHOI1 DMEHOI1 DN Novaferon DMEHOI1 MI TTSIUJ9 DMEHOI1 MN Interferon-alpha 2 (IFNA2) DMEHOI1 MT DTT DMEHOI1 MA Modulator DMEHOI1 RN Novaferon, a novel recombinant protein produced by DNA-shuffling of IFN-alpha, shows antitumor effect in vitro and in vivo. Cancer Cell Int. 2014; 14: 8. DMEHOI1 RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3976097/ DMHG3UR DI DMHG3UR DMHG3UR DN NOX-E36 DMHG3UR MI TTNAY0P DMHG3UR MN Monocyte chemotactic and activating factor (CCL2) DMHG3UR MT DTT DMHG3UR MA Inhibitor DMHG3UR RN Crystal structure of a mirror-image L-RNA aptamer (Spiegelmer) in complex with the natural L-protein target CCL2. Nat Commun. 2015 Apr 22;6:6923. DMHG3UR RU https://pubmed.ncbi.nlm.nih.gov/25901662 DM5HPZU DI DM5HPZU DM5HPZU DN NOX-H94 DM5HPZU MI TTPCG5T DM5HPZU MN Hepcidin (HAMP) DM5HPZU MT DTT DM5HPZU MA Inhibitor DM5HPZU RN The effects of the anti-hepcidin Spiegelmer NOX-H94 on inflammation-induced anemia in cynomolgus monkeys. Blood. 2013 Mar 21;121(12):2311-5. DM5HPZU RU https://pubmed.ncbi.nlm.nih.gov/23349391 DMP1W9Z DI DMP1W9Z DMP1W9Z DN NP-01 DMP1W9Z MI TTCBFJO DMP1W9Z MN Insulin receptor (INSR) DMP1W9Z MT DTT DMP1W9Z MA Agonist DMP1W9Z RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1800). DMP1W9Z RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1800 DMLMZ6Q DI DMLMZ6Q DMLMZ6Q DN NP-2 DMLMZ6Q MI TTN4QDT DMLMZ6Q MN Opioid receptor (OPR) DMLMZ6Q MT DTT DMLMZ6Q MA Antagonist DMLMZ6Q RN Vascular endothelial growth factor receptor-1 and neuropilin-2 form complexes. J Biol Chem. 2001 Jun 1;276(22):18688-94. DMLMZ6Q RU https://pubmed.ncbi.nlm.nih.gov/11278319 DME6KAF DI DME6KAF DME6KAF DN NPC-15199 DME6KAF MI TTW6MKR DME6KAF MN Calcium release (Ca rele) DME6KAF MT DTT DME6KAF MA Modulator DME6KAF RN NPC-15199, a novel anti-inflammatory agent, mobilizes intracellular Ca2+ in bladder female transitional carcinoma (BFTC) cells. Chin J Physiol. 2000 Mar 31;43(1):29-33. DME6KAF RU https://pubmed.ncbi.nlm.nih.gov/10857466 DM9VEAL DI DM9VEAL DM9VEAL DN NPC-1C DM9VEAL MI TT34I9F DM9VEAL MN Neoplasm antigen (NA) DM9VEAL MT DTT DM9VEAL RN National Cancer Institute Drug Dictionary (drug id 663436). DM9VEAL RU http://www.cancer.gov/publications/dictionaries/cancer-drug?cdrid=663436 DM3DQXG DI DM3DQXG DM3DQXG DN NPSP-795 DM3DQXG MI TTEPJL5 DM3DQXG MN Parathyroid hormone receptor (PTH2R) DM3DQXG MT DTT DM3DQXG MA Modulator DM3DQXG RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 332). DM3DQXG RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=332 DMYXOU2 DI DMYXOU2 DMYXOU2 DN NRX-4204 DMYXOU2 MI TTH029C DMYXOU2 MN Retinoic acid receptor RXR-gamma (RXRG) DMYXOU2 MT DTT DMYXOU2 MA Modulator DMYXOU2 RN DOI: 10.1038/scibx.2010.766 DMYXOU2 RU http://www.nature.com/scibx/journal/v3/n25/full/scibx.2010.766.html DM9EFH0 DI DM9EFH0 DM9EFH0 DN NS 1209 DM9EFH0 MI TT0MYE2 DM9EFH0 MN Glutamate receptor ionotropic kainate 1 (GRIK1) DM9EFH0 MT DTT DM9EFH0 MA Modulator DM9EFH0 RN The efficacy of the AMPA receptor antagonist NS1209 and lidocaine in nerve injury pain: a randomized, double-blind, placebo-controlled, three-way crossover study. Anesth Analg. 2009 Apr;108(4):1311-9. DM9EFH0 RU https://pubmed.ncbi.nlm.nih.gov/19299805 DMI5HFU DI DMI5HFU DMI5HFU DN NS 2359 DMI5HFU MI TTVBI8W DMI5HFU MN Dopamine transporter (DAT) DMI5HFU MT DTT DMI5HFU MA Inhibitor DMI5HFU RN Novel drugs and therapeutic targets for severe mood disorders. Neuropsychopharmacology. 2008 Aug;33(9):2080-92. DMI5HFU RU https://pubmed.ncbi.nlm.nih.gov/18172433 DMI5HFU DI DMI5HFU DMI5HFU DN NS 2359 DMI5HFU MI TTAWNKZ DMI5HFU MN Norepinephrine transporter (NET) DMI5HFU MT DTT DMI5HFU MA Inhibitor DMI5HFU RN Novel drugs and therapeutic targets for severe mood disorders. Neuropsychopharmacology. 2008 Aug;33(9):2080-92. DMI5HFU RU https://pubmed.ncbi.nlm.nih.gov/18172433 DMI5HFU DI DMI5HFU DMI5HFU DN NS 2359 DMI5HFU MI TT3ROYC DMI5HFU MN Serotonin transporter (SERT) DMI5HFU MT DTT DMI5HFU MA Inhibitor DMI5HFU RN Novel drugs and therapeutic targets for severe mood disorders. Neuropsychopharmacology. 2008 Aug;33(9):2080-92. DMI5HFU RU https://pubmed.ncbi.nlm.nih.gov/18172433 DMMUR6V DI DMMUR6V DMMUR6V DN NS-2710 DMMUR6V MI TT37EDJ DMMUR6V MN GABA(A) receptor alpha-3 (GABRA3) DMMUR6V MT DTT DMMUR6V MA Modulator DMMUR6V RN GABAA receptor subtype-selective modulators. I. alpha2/alpha3-selective agonists as non-sedating anxiolytics. Curr Top Med Chem. 2011;11(9):1176-202. DMMUR6V RU https://pubmed.ncbi.nlm.nih.gov/21050172 DM3H82Q DI DM3H82Q DM3H82Q DN NS-7 DM3H82Q MI TTRK8B9 DM3H82Q MN Sodium channel unspecific (NaC) DM3H82Q MT DTT DM3H82Q MA Modulator DM3H82Q RN Preferential inhibition by a novel Na(+)/Ca(2+) channel blocker NS-7 of severe to mild hypoxic injury in rat cerebrocortical slices: A possible involvement of a highly voltage-dependent blockade of Ca(2+) channel. J Pharmacol Exp Ther. 2000 May;293(2):522-9. DM3H82Q RU https://pubmed.ncbi.nlm.nih.gov/10773024 DMPJQZG DI DMPJQZG DMPJQZG DN NSC-645809 DMPJQZG MI DTI7UX6 DMPJQZG MN Breast cancer resistance protein (ABCG2) DMPJQZG MT DTP DMPJQZG MA Substrate DMPJQZG RN C421 allele-specific ABCG2 gene amplification confers resistance to the antitumor triazoloacridone C-1305 in human lung cancer cells. Biochem Pharmacol. 2007 Jun 30;74(1):41-53. DMPJQZG RU https://doi.org/10.1016/j.bcp.2007.03.028 DMPJQZG DI DMPJQZG DMPJQZG DN NSC-645809 DMPJQZG MI TTJLP0R DMPJQZG MN Quinone reductase 2 (NQO2) DMPJQZG MT DTT DMPJQZG MA Inhibitor DMPJQZG RN Imidazoacridin-6-ones as novel inhibitors of the quinone oxidoreductase NQO2. Bioorg Med Chem Lett. 2010 May 1;20(9):2832-6. DMPJQZG RU https://pubmed.ncbi.nlm.nih.gov/20356739 DMRYLBW DI DMRYLBW DMRYLBW DN NTO-1151 DMRYLBW MI TTRBUYN DMRYLBW MN Ribonuclease (RNase) DMRYLBW MT DTT DMRYLBW MA Modulator DMRYLBW RN Clinical pipeline report, company report or official report of Nanotherapeutics. DMRYLBW RU http://www.nanotherapeutics.com/triapine/ DMORNVB DI DMORNVB DMORNVB DN NU-172 DMORNVB MI TT6L509 DMORNVB MN Coagulation factor IIa (F2) DMORNVB MT DTT DMORNVB MA Inhibitor DMORNVB RN Nucleic acid aptamers: clinical applications and promising new horizons. Curr Med Chem. 2011; 18(27): 4206-4214. DMORNVB RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3260938/ DMO0C5R DI DMO0C5R DMO0C5R DN NU300 DMO0C5R MI TTC6JZQ DMO0C5R MN Haemophilus influenzae CRM197 (Hae-influ CRM197) DMO0C5R MT DTT DMO0C5R MA Modulator DMO0C5R RN ClinicalTrials.gov (NCT02140047) Exploratory Clinical Study of MT-2301. U.S. National Institutes of Health. DMO0C5R RU https://clinicaltrials.gov/ct2/show/NCT02140047 DMOJA5G DI DMOJA5G DMOJA5G DN Nuplazid DMOJA5G MI TTJQOD7 DMOJA5G MN 5-HT 2A receptor (HTR2A) DMOJA5G MT DTT DMOJA5G MA Agonist DMOJA5G RN The neuropharmacology of sleep paralysis hallucinations: serotonin 2A activation and a novel therapeutic drug. Psychopharmacology (Berl). 2018 Nov;235(11):3083-3091. DMOJA5G RU https://pubmed.ncbi.nlm.nih.gov/30288594 DMOJA5G DI DMOJA5G DMOJA5G DN Nuplazid DMOJA5G MI TTWJBZ5 DMOJA5G MN 5-HT 2C receptor (HTR2C) DMOJA5G MT DTT DMOJA5G MA Agonist DMOJA5G RN The neuropharmacology of sleep paralysis hallucinations: serotonin 2A activation and a novel therapeutic drug. Psychopharmacology (Berl). 2018 Nov;235(11):3083-3091. DMOJA5G RU https://pubmed.ncbi.nlm.nih.gov/30288594 DMTYXQF DI DMTYXQF DMTYXQF DN NVP-AUY922 DMTYXQF MI TT78R5H DMTYXQF MN Heat shock protein 90 alpha (HSP90A) DMTYXQF MT DTT DMTYXQF MA Inhibitor DMTYXQF RN Recent advances in Hsp90 inhibitors as antitumor agents. Anticancer Agents Med Chem. 2008 Oct;8(7):761-82. DMTYXQF RU https://pubmed.ncbi.nlm.nih.gov/18855578 DM2UJ1H DI DM2UJ1H DM2UJ1H DN NW-3509 DM2UJ1H MI TTRK8B9 DM2UJ1H MN Sodium channel unspecific (NaC) DM2UJ1H MT DTT DM2UJ1H MA Blocker DM2UJ1H RN Clinical pipeline report, company report or official report of Newron. DM2UJ1H RU http://www.newron.com/eng/Default.aspx?SEZ=3&PAG=52 DMMBAIH DI DMMBAIH DMMBAIH DN NXN-188 DMMBAIH MI TTK8CXU DMMBAIH MN 5-HT 1B receptor (HTR1B) DMMBAIH MT DTT DMMBAIH MA Modulator DMMBAIH RN Company report (NeurAxon) DMMBAIH RU http://www.neuraxon.com/103110.html DMMBAIH DI DMMBAIH DMMBAIH DN NXN-188 DMMBAIH MI TT6MSOK DMMBAIH MN 5-HT 1D receptor (HTR1D) DMMBAIH MT DTT DMMBAIH MA Modulator DMMBAIH RN Company report (NeurAxon) DMMBAIH RU http://www.neuraxon.com/103110.html DMMBAIH DI DMMBAIH DMMBAIH DN NXN-188 DMMBAIH MI TTZUFI5 DMMBAIH MN Nitric-oxide synthase brain (NOS1) DMMBAIH MT DTT DMMBAIH MA Inhibitor DMMBAIH RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMMBAIH RU http://phrma-docs.phrma.org/files/dmfile/MID_Neurological-Disorders-Drug-List_2018.pdf DMWVBS2 DI DMWVBS2 DMWVBS2 DN NXN-462 DMWVBS2 MI TTZUFI5 DMWVBS2 MN Nitric-oxide synthase brain (NOS1) DMWVBS2 MT DTT DMWVBS2 MA Inhibitor DMWVBS2 RN ClinicalTrials.gov (NCT01748877) Efficacy, Tolerability, and Safety of NXN-462 in Patients With Post-Herpetic Neuralgia. U.S. National Institutes of Health. DMWVBS2 RU https://clinicaltrials.gov/ct2/show/NCT01748877 DM1P60V DI DM1P60V DM1P60V DN NYX-2925 DM1P60V MI TT9IK2Z DM1P60V MN N-methyl-D-aspartate receptor (NMDAR) DM1P60V MT DTT DM1P60V MA Modulator DM1P60V RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DM1P60V RU http://phrma-docs.phrma.org/files/dmfile/MID_Neurological-Disorders-Drug-List_2018.pdf DMX04O8 DI DMX04O8 DMX04O8 DN NYX-2925 DMX04O8 MI TT9IK2Z DMX04O8 MN N-methyl-D-aspartate receptor (NMDAR) DMX04O8 MT DTT DMX04O8 MA Modulator DMX04O8 RN NYX-2925 Is a Novel N-Methyl-d-Aspartate Receptor Modulator that Induces Rapid and Long-Lasting Analgesia in Rat Models of Neuropathic Pain. J Pharmacol Exp Ther. 2018 Sep;366(3):485-497. DMX04O8 RU https://pubmed.ncbi.nlm.nih.gov/29986951 DMAVM2E DI DMAVM2E DMAVM2E DN NYX-783 DMAVM2E MI TT9IK2Z DMAVM2E MN N-methyl-D-aspartate receptor (NMDAR) DMAVM2E MT DTT DMAVM2E MA Modulator DMAVM2E RN Clinical pipeline report, company report or official report of Aptinyx. DMAVM2E RU https://www.aptinyx.com/pipeline/ DMXM34I DI DMXM34I DMXM34I DN O-304 DMXM34I MI TTLAFZV DMXM34I MN AMP-activated protein kinase (AMPK) DMXM34I MT DTT DMXM34I MA Activator DMXM34I RN Clinical pipeline report, company report or official report of Betagenon. DMXM34I RU https://betagenon.com/research-development/o304-our-ampk-activator DMPF9ZM DI DMPF9ZM DMPF9ZM DN Obatoclax DMPF9ZM MI TTJGNVC DMPF9ZM MN Apoptosis regulator Bcl-2 (BCL-2) DMPF9ZM MT DTT DMPF9ZM MA Inhibitor DMPF9ZM RN Phase II study of obatoclax mesylate (GX15-070), a small-molecule BCL-2 family antagonist, for patients with myelofibrosis. Clin Lymphoma Myeloma Leuk. 2010 Aug;10(4):285-9. DMPF9ZM RU https://pubmed.ncbi.nlm.nih.gov/20709666 DMPF9ZM DI DMPF9ZM DMPF9ZM DN Obatoclax DMPF9ZM MI TTU1E82 DMPF9ZM MN Apoptosis regulator Bcl-xL (BCL-xL) DMPF9ZM MT DTT DMPF9ZM MA Inhibitor DMPF9ZM RN Phase II study of obatoclax mesylate (GX15-070), a small-molecule BCL-2 family antagonist, for patients with myelofibrosis. Clin Lymphoma Myeloma Leuk. 2010 Aug;10(4):285-9. DMPF9ZM RU https://pubmed.ncbi.nlm.nih.gov/20709666 DMPF9ZM DI DMPF9ZM DMPF9ZM DN Obatoclax DMPF9ZM MI TTL53M6 DMPF9ZM MN Induced myeloid leukemia cell differentiation protein Mcl-1 (MCL1) DMPF9ZM MT DTT DMPF9ZM MA Inhibitor DMPF9ZM RN Phase II study of obatoclax mesylate (GX15-070), a small-molecule BCL-2 family antagonist, for patients with myelofibrosis. Clin Lymphoma Myeloma Leuk. 2010 Aug;10(4):285-9. DMPF9ZM RU https://pubmed.ncbi.nlm.nih.gov/20709666 DMJIBSG DI DMJIBSG DMJIBSG DN OBE-101 DMJIBSG MI TTTIBOJ DMJIBSG MN Histamine H1 receptor (H1R) DMJIBSG MT DTT DMJIBSG MA Modulator DMJIBSG RN Betahistine in the treatment of M ni re's disease. Neuropsychiatr Dis Treat. 2007 August; 3(4): 429-440. DMJIBSG RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2655085/ DM5D6Y7 DI DM5D6Y7 DM5D6Y7 DN OBI-3424 DM5D6Y7 MI TTUTN1I DM5D6Y7 MN Human Deoxyribonucleic acid (hDNA) DM5D6Y7 MT DTT DM5D6Y7 RN OBI-3424, a Novel AKR1C3-Activated Prodrug, Exhibits Potent Efficacy against Preclinical Models of T-ALL. Clin Cancer Res. 2019 Jul 15;25(14):4493-4503. DM5D6Y7 RU https://pubmed.ncbi.nlm.nih.gov/31015346 DMVXZC4 DI DMVXZC4 DMVXZC4 DN OBP-601 DMVXZC4 MI TT84ETX DMVXZC4 MN Human immunodeficiency virus Reverse transcriptase (HIV RT) DMVXZC4 MT DTT DMVXZC4 MA Inhibitor DMVXZC4 RN Antiviral drug resistance and the need for development of new HIV-1 reverse transcriptase inhibitors. Antimicrob Agents Chemother. 2012 Oct;56(10):5000-8. DMVXZC4 RU https://pubmed.ncbi.nlm.nih.gov/22733071 DM1JBD8 DI DM1JBD8 DM1JBD8 DN OC-000459 DM1JBD8 MI TTQDMX5 DM1JBD8 MN Prostaglandin D2 receptor 2 (PTGDR2) DM1JBD8 MT DTT DM1JBD8 MA Antagonist DM1JBD8 RN Anti-eosinophil activity and clinical efficacy of the CRTH2 antagonist OC000459 in eosinophilic esophagitis. Allergy. 2013 Mar;68(3):375-85. DM1JBD8 RU https://pubmed.ncbi.nlm.nih.gov/23379537 DMP6B59 DI DMP6B59 DMP6B59 DN Ocaperidone DMP6B59 MI TTJQOD7 DMP6B59 MN 5-HT 2A receptor (HTR2A) DMP6B59 MT DTT DMP6B59 MA Modulator DMP6B59 RN Pharmacological profile of the new potent neuroleptic ocaperidone (R 79,598). J Pharmacol Exp Ther. 1992 Jan;260(1):146-59. DMP6B59 RU https://pubmed.ncbi.nlm.nih.gov/1370538 DMP6B59 DI DMP6B59 DMP6B59 DN Ocaperidone DMP6B59 MI TTSECX1 DMP6B59 MN Connective tissue growth factor (CTGF) DMP6B59 MT DTT DMP6B59 MA Inhibitor DMP6B59 RN Current and emerging drugs for idiopathic pulmonary fibrosis. Expert Opin Emerg Drugs. 2007 Nov;12(4):627-46. DMP6B59 RU https://pubmed.ncbi.nlm.nih.gov/17979604 DMP6B59 DI DMP6B59 DMP6B59 DN Ocaperidone DMP6B59 MI TTEX248 DMP6B59 MN Dopamine D2 receptor (D2R) DMP6B59 MT DTT DMP6B59 MA Modulator DMP6B59 RN Pharmacological profile of the new potent neuroleptic ocaperidone (R 79,598). J Pharmacol Exp Ther. 1992 Jan;260(1):146-59. DMP6B59 RU https://pubmed.ncbi.nlm.nih.gov/1370538 DM8TDBY DI DM8TDBY DM8TDBY DN OCFENTANIL DM8TDBY MI TTN4QDT DM8TDBY MN Opioid receptor (OPR) DM8TDBY MT DTT DM8TDBY MA Modulator DM8TDBY RN Comparison of ocfentanil and fentanyl as supplements to general anesthesia. Anesth Analg. 1991 Nov;73(5):622-6. DM8TDBY RU https://pubmed.ncbi.nlm.nih.gov/1952145 DMT9QI2 DI DMT9QI2 DMT9QI2 DN OCV-101 DMT9QI2 MI TT2Q6G1 DMT9QI2 MN Vascular endothelial growth factor receptor 1 (FLT-1) DMT9QI2 MT DTT DMT9QI2 MA Modulator DMT9QI2 RN Phase I trial of OTS11101, an anti-angiogenic vaccine targeting vascular endothelial growth factor receptor 1 in solid tumor.Cancer Sci.2013 Jan;104(1):98-104. DMT9QI2 RU https://www.ncbi.nlm.nih.gov/pubmed/23020774 DMK0MJP DI DMK0MJP DMK0MJP DN Odelepran DMK0MJP MI TTN4QDT DMK0MJP MN Opioid receptor (OPR) DMK0MJP MT DTT DMK0MJP MA Antagonist DMK0MJP RN A phase 2, placebo-controlled study of the opioid receptor antagonist LY2196044 for the treatment of alcohol dependence. Alcohol Clin Exp Res. 2014 Feb;38(2):511-20. DMK0MJP RU https://pubmed.ncbi.nlm.nih.gov/24010675 DMJL4A7 DI DMJL4A7 DMJL4A7 DN O-desulfated heparin DMJL4A7 MI TT4QPUL DMJL4A7 MN Antithrombin-III (ATIII) DMJL4A7 MT DTT DMJL4A7 MA Modulator DMJL4A7 RN Structural determinants of the capacity of heparin to inhibit the formation of the human amplification C3 convertase. J Clin Invest. 1981 Jan;67(1):223-8. DMJL4A7 RU https://pubmed.ncbi.nlm.nih.gov/6778897 DMWCBY7 DI DMWCBY7 DMWCBY7 DN Odiparcil DMWCBY7 MI TT6L509 DMWCBY7 MN Coagulation factor IIa (F2) DMWCBY7 MT DTT DMWCBY7 MA Inhibitor DMWCBY7 RN A comparison of the beta-D-xyloside, odiparcil, to warfarin in a rat model of venous thrombosis. J Thromb Haemost. 2006 Sep;4(9):1989-96. DMWCBY7 RU https://pubmed.ncbi.nlm.nih.gov/16961606 DMVC90W DI DMVC90W DMVC90W DN Oglemilast DMVC90W MI TTZ97H5 DMVC90W MN Phosphodiesterase 4A (PDE4A) DMVC90W MT DTT DMVC90W MA Inhibitor DMVC90W RN Can the anti-inflammatory potential of PDE4 inhibitors be realized: guarded optimism or wishful thinking . Br J Pharmacol. 2008 October; 155(3): 288-290. DMVC90W RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2567889/ DMVC90W DI DMVC90W DMVC90W DN Oglemilast DMVC90W MI TTVIAT9 DMVC90W MN Phosphodiesterase 4B (PDE4B) DMVC90W MT DTT DMVC90W MA Inhibitor DMVC90W RN Can the anti-inflammatory potential of PDE4 inhibitors be realized: guarded optimism or wishful thinking . Br J Pharmacol. 2008 October; 155(3): 288-290. DMVC90W RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2567889/ DMVC90W DI DMVC90W DMVC90W DN Oglemilast DMVC90W MI TTSKMI8 DMVC90W MN Phosphodiesterase 4D (PDE4D) DMVC90W MT DTT DMVC90W MA Inhibitor DMVC90W RN Can the anti-inflammatory potential of PDE4 inhibitors be realized: guarded optimism or wishful thinking . Br J Pharmacol. 2008 October; 155(3): 288-290. DMVC90W RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2567889/ DMJTU8D DI DMJTU8D DMJTU8D DN OGX-427 DMJTU8D MI TTMG98T DMJTU8D MN Heat shock protein 27 (HSP27) DMJTU8D MT DTT DMJTU8D MA Modulator DMJTU8D RN Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41. DMJTU8D RU https://www.ncbi.nlm.nih.gov/pubmed/15950434 DMNEHY1 DI DMNEHY1 DMNEHY1 DN OI338GT DMNEHY1 MI TTVIMDE DMNEHY1 MN Glucagon-like peptide 1 receptor (GLP1R) DMNEHY1 MT DTT DMNEHY1 MA Modulator DMNEHY1 RN Clinical pipeline report, company report or official report of Novo Nordisk A/S. DMNEHY1 RU http://www.novonordisk.com/bin/getPDF.1781915.pdf DMVW5KR DI DMVW5KR DMVW5KR DN Olcegepant DMVW5KR MI TTY6O0Q DMVW5KR MN Calcitonin gene-related peptide receptor (CGRPR) DMVW5KR MT DTT DMVW5KR MA Modulator DMVW5KR RN Olcegepant, a non-peptide CGRP1 antagonist for migraine treatment. IDrugs. 2007 Aug;10(8):566-74. DMVW5KR RU https://www.ncbi.nlm.nih.gov/pubmed/17665333 DM0RA8F DI DM0RA8F DM0RA8F DN Oleoyl-estrone DM0RA8F MI TTXJ47W DM0RA8F MN Metabotropic glutamate receptor 2 (mGluR2) DM0RA8F MT DTT DM0RA8F MA Agonist DM0RA8F RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DM0RA8F RU http://phrma-docs.phrma.org/files/dmfile/MID_Neurological-Disorders-Drug-List_2018.pdf DM0RA8F DI DM0RA8F DM0RA8F DN Oleoyl-estrone DM0RA8F MI TT8A9EF DM0RA8F MN Metabotropic glutamate receptor 3 (mGluR3) DM0RA8F MT DTT DM0RA8F MA Agonist DM0RA8F RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DM0RA8F RU http://phrma-docs.phrma.org/files/dmfile/MID_Neurological-Disorders-Drug-List_2018.pdf DMXL7HO DI DMXL7HO DMXL7HO DN OLX10010 DMXL7HO MI TTIL516 DMXL7HO MN CCN2 messenger RNA (CCN2 mRNA) DMXL7HO MT DTT DMXL7HO MA Inhibitor DMXL7HO RN Clinical pipeline report, company report or official report of Olix Pharmaceuticals. DMXL7HO RU https://www.olixpharma.com/eng/rnd/rnd03_olx101a.php DMLMNFX DI DMLMNFX DMLMNFX DN Omaveloxolone DMLMNFX MI TTA6ZN2 DMLMNFX MN Nuclear factor erythroid 2-related factor 2 (Nrf2) DMLMNFX MT DTT DMLMNFX MA Activator DMLMNFX RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMLMNFX RU http://phrma-docs.phrma.org/files/dmfile/MID_Skin_Diseases_2018_9_FINAL.pdf DMH9RTV DI DMH9RTV DMH9RTV DN Omigapil DMH9RTV MI TTUGSWA DMH9RTV MN Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) DMH9RTV MT DTT DMH9RTV MA Modulator DMH9RTV RN Neuroprotection by pharmacologic blockade of the GAPDH death cascade. Proc Natl Acad Sci U S A. 2006 Mar 7;103(10):3887-9. DMH9RTV RU https://pubmed.ncbi.nlm.nih.gov/16505364 DMWC36Y DI DMWC36Y DMWC36Y DN OMS405 DMWC36Y MI TTZMAO3 DMWC36Y MN Peroxisome proliferator-activated receptor gamma (PPAR-gamma) DMWC36Y MT DTT DMWC36Y MA Agonist DMWC36Y RN Clinical pipeline report, company report or official report of Avarx. DMWC36Y RU http://www.avarx.com/AvaRx/SubDomains/bucket4984694478449561395/Listings/bucket4040741479008611375/Public.Listing.display.html DMA4OGL DI DMA4OGL DMA4OGL DN OMS824 DMA4OGL MI TTJW4LU DMA4OGL MN Phosphodiesterase 10A (PDE10) DMA4OGL MT DTT DMA4OGL MA Inhibitor DMA4OGL RN New Drugs/Drug News. P T. 2013 November; 38(11): 667-672. DMA4OGL RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3875261/ DMT6E5N DI DMT6E5N DMT6E5N DN Onapristone DMT6E5N MI DE4LYSA DMT6E5N MN Cytochrome P450 3A4 (CYP3A4) DMT6E5N MT DME DMT6E5N MA Metabolism DMT6E5N RN Drug-metabolizing enzymes and transporters: expression in the human prostate and roles in prostate drug disposition. J Androl. 2006 Mar-Apr;27(2):138-50. DMT6E5N RU https://www.ncbi.nlm.nih.gov/pubmed/?term=16330661 DMT6E5N DI DMT6E5N DMT6E5N DN Onapristone DMT6E5N MI TTUV8G9 DMT6E5N MN Progesterone receptor (PGR) DMT6E5N MT DTT DMT6E5N MA Modulator DMT6E5N RN Onapristone, a progesterone receptor antagonist, as first-line therapy in primary breast cancer. Eur J Cancer. 1999 Feb;35(2):214-8. DMT6E5N RU https://www.ncbi.nlm.nih.gov/pubmed/10448262 DMM5SCF DI DMM5SCF DMM5SCF DN ONC201 DMM5SCF MI TTEX248 DMM5SCF MN Dopamine D2 receptor (D2R) DMM5SCF MT DTT DMM5SCF MA Antagonist DMM5SCF RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMM5SCF RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DMM5SCF DI DMM5SCF DMM5SCF DN ONC201 DMM5SCF MI TT4C8EA DMM5SCF MN Dopamine D3 receptor (D3R) DMM5SCF MT DTT DMM5SCF MA Antagonist DMM5SCF RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMM5SCF RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DMM5SCF DI DMM5SCF DMM5SCF DN ONC201 DMM5SCF MI TTWFZ1N DMM5SCF MN Dopamine receptor (DR) DMM5SCF MT DTT DMM5SCF MA Antagonist DMM5SCF RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMM5SCF RU http://phrma-docs.phrma.org/files/dmfile/MID_Neurological-Disorders-Drug-List_2018.pdf DMKIZAL DI DMKIZAL DMKIZAL DN ONO-1603 DMKIZAL MI TTNGKET DMKIZAL MN Prolyl endopeptidase (PREP) DMKIZAL MT DTT DMKIZAL MA Modulator DMKIZAL RN ONO-1603, a potential antidementia drug, shows neuroprotective effects and increases m3-muscarinic receptor mRNA levels in differentiating rat cerebellar granule neurons. Neurosci Lett. 1996 Aug 23;214(2-3):151-4. DMKIZAL RU https://pubmed.ncbi.nlm.nih.gov/8878106 DMOT0WR DI DMOT0WR DMOT0WR DN ONO-2333Ms DMOT0WR MI TT7EFHR DMOT0WR MN Corticotropin-releasing factor receptor 1 (CRHR1) DMOT0WR MT DTT DMOT0WR MA Antagonist DMOT0WR RN Behavioral, biological, and chemical perspectives on targeting CRF(1) receptor antagonists to treat alcoholism. Drug Alcohol Depend. 2013 Mar 1;128(3):175-86. DMOT0WR RU https://pubmed.ncbi.nlm.nih.gov/23294766 DMOGYQ0 DI DMOGYQ0 DMOGYQ0 DN ONO-2952 DMOGYQ0 MI TTPTXIN DMOGYQ0 MN Translocator protein (TSPO) DMOGYQ0 MT DTT DMOGYQ0 MA Antagonist DMOGYQ0 RN Anti-stress effects of ONO-2952, a novel translocator protein 18 kDa antagonist, in rats. Neuropharmacology. 2015 Jul 17;99:51-66. DMOGYQ0 RU https://pubmed.ncbi.nlm.nih.gov/26189762 DMQGO74 DI DMQGO74 DMQGO74 DN ONO-3307 DMQGO74 MI TTZBFA0 DMQGO74 MN Protease unspecific (PRO) DMQGO74 MT DTT DMQGO74 MA Modulator DMQGO74 RN Inhibitory effects of ONO-3307 on various proteases and tissue thromboplastin in vitro and on experimental thrombosis in vivo. Jpn J Pharmacol. 1989 Dec;51(4):455-63. DMQGO74 RU https://pubmed.ncbi.nlm.nih.gov/2515329 DMX4MVP DI DMX4MVP DMX4MVP DN ONO-4053 DMX4MVP MI TTNVEIR DMX4MVP MN Prostaglandin D2 receptor (PTGDR) DMX4MVP MT DTT DMX4MVP MA Antagonist DMX4MVP RN Effect of ONO-4053, a DP1 (prostaglandin D2 receptor) Antagonist, on Prostaglandin D2-Induced Nasal Congestion. Journal of Allergy and Clinical Immunology Volume 135, Issue 2, Supplement, February 2015, Pages AB219. DMX4MVP RU http://www.sciencedirect.com/science/article/pii/S0091674914034332 DMLUM3Y DI DMLUM3Y DMLUM3Y DN ONO-4641 DMLUM3Y MI TT9JZCK DMLUM3Y MN Sphingosine-1-phosphate receptor 1 (S1PR1) DMLUM3Y MT DTT DMLUM3Y MA Agonist DMLUM3Y RN Targeting the sphingosine-1-phosphate axis in cancer, inflammation and beyond. Nat Rev Drug Discov. 2013 Sep;12(9):688-702. DMLUM3Y RU https://pubmed.ncbi.nlm.nih.gov/23954895 DMFX3P1 DI DMFX3P1 DMFX3P1 DN ONO-5129 DMFX3P1 MI TTJ584C DMFX3P1 MN Peroxisome proliferator-activated receptor alpha (PPARA) DMFX3P1 MT DTT DMFX3P1 MA Modulator DMFX3P1 RN Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41. DMFX3P1 RU https://www.ncbi.nlm.nih.gov/pubmed/15950434 DMFX3P1 DI DMFX3P1 DMFX3P1 DN ONO-5129 DMFX3P1 MI TTZMAO3 DMFX3P1 MN Peroxisome proliferator-activated receptor gamma (PPAR-gamma) DMFX3P1 MT DTT DMFX3P1 MA Modulator DMFX3P1 RN Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41. DMFX3P1 RU https://www.ncbi.nlm.nih.gov/pubmed/15950434 DMRT28X DI DMRT28X DMRT28X DN ONO-6126 DMRT28X MI DTUGYRD DMRT28X MN P-glycoprotein 1 (ABCB1) DMRT28X MT DTP DMRT28X MA Substrate DMRT28X RN Fingerprint-based in silico models for the prediction of P-glycoprotein substrates and inhibitors. Bioorg Med Chem. 2012 Sep 15;20(18):5388-95. DMRT28X RU https://doi.org/10.1016/j.bmc.2012.03.045 DMRT28X DI DMRT28X DMRT28X DN ONO-6126 DMRT28X MI TTV5CGO DMRT28X MN Phosphodiesterase 4 (PDE4) DMRT28X MT DTT DMRT28X MA Inhibitor DMRT28X RN Emerging drugs for the treatment of chronic obstructive pulmonary disease. Expert Opin Emerg Drugs. 2006 May;11(2):275-91. DMRT28X RU https://pubmed.ncbi.nlm.nih.gov/16634702 DM5O6GC DI DM5O6GC DM5O6GC DN ONO-9054 DM5O6GC MI TTPNGDE DM5O6GC MN Prostaglandin E2 receptor EP3 (PTGER3) DM5O6GC MT DTT DM5O6GC MA Modulator DM5O6GC RN IOP-Lowering Effect of ONO-9054, A Novel Dual Agonist of Prostanoid EP3 and FP Receptors, in Monkeys. Invest Ophthalmol Vis Sci. 2015 Apr;56(4):2547-52. DM5O6GC RU https://pubmed.ncbi.nlm.nih.gov/25788650 DM5O6GC DI DM5O6GC DM5O6GC DN ONO-9054 DM5O6GC MI TTT2ZAR DM5O6GC MN Prostaglandin F2-alpha receptor (PTGFR) DM5O6GC MT DTT DM5O6GC MA Modulator DM5O6GC RN IOP-Lowering Effect of ONO-9054, A Novel Dual Agonist of Prostanoid EP3 and FP Receptors, in Monkeys. Invest Ophthalmol Vis Sci. 2015 Apr;56(4):2547-52. DM5O6GC RU https://pubmed.ncbi.nlm.nih.gov/25788650 DMCUGI8 DI DMCUGI8 DMCUGI8 DN ONO-AE1-437 DMCUGI8 MI TT79WV3 DMCUGI8 MN Prostaglandin E2 receptor EP4 (PTGER4) DMCUGI8 MT DTT DMCUGI8 MA Agonist DMCUGI8 RN An EP4 receptor agonist prevents indomethacin-induced closure of rat ductus arteriosus in vivo. Pediatr Res. 2004 Oct;56(4):586-90. DMCUGI8 RU https://pubmed.ncbi.nlm.nih.gov/15295094 DMS8Q7A DI DMS8Q7A DMS8Q7A DN Ontazolast DMS8Q7A MI TTTWGIX DMS8Q7A MN Leukotriene receptor (LTR) DMS8Q7A MT DTT DMS8Q7A MA Modulator DMS8Q7A RN Effects of progesterone and leukotriene receptor antagonists in experimental models of P-glycoprotein-related resistance. Eur J Med Res. 1997 Apr 21;2(4):159-64. DMS8Q7A RU https://pubmed.ncbi.nlm.nih.gov/9110922 DM0FJIE DI DM0FJIE DM0FJIE DN Ontuxizumab DM0FJIE MI TTYJWT7 DM0FJIE MN Endosialin (CD248) DM0FJIE MT DTT DM0FJIE MA Inhibitor DM0FJIE RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DM0FJIE RU http://phrma-docs.phrma.org/files/dmfile/MID_Immuno-Oncology-2017_Drug-List1.pdf DMB1WF3 DI DMB1WF3 DMB1WF3 DN OPC-14523 DMB1WF3 MI TTSQIFT DMB1WF3 MN 5-HT 1A receptor (HTR1A) DMB1WF3 MT DTT DMB1WF3 MA Modulator DMB1WF3 RN Antidepressant-like responses to the combined sigma and 5-HT1A receptor agonist OPC-14523. Neuropharmacology. 2001 Dec;41(8):976-88. DMB1WF3 RU https://www.ncbi.nlm.nih.gov/pubmed/11747902 DMB1WF3 DI DMB1WF3 DMB1WF3 DN OPC-14523 DMB1WF3 MI TT5TPI6 DMB1WF3 MN Opioid receptor sigma 1 (OPRS1) DMB1WF3 MT DTT DMB1WF3 MA Modulator DMB1WF3 RN Antidepressant-like responses to the combined sigma and 5-HT1A receptor agonist OPC-14523. Neuropharmacology. 2001 Dec;41(8):976-88. DMB1WF3 RU https://www.ncbi.nlm.nih.gov/pubmed/11747902 DMIK2AD DI DMIK2AD DMIK2AD DN OPC-64005 DMIK2AD MI TT8G3Z7 DMIK2AD MN Serotoninnorepinephrinedopamine reuptake (SNDR) DMIK2AD MT DTT DMIK2AD MA Inhibitor DMIK2AD RN Clinical pipeline report, company report or official report of Otsuka Pharmaceutical. DMIK2AD RU https://www.otsuka.co.jp/en/research-and-development/pipeline/ DML6TAS DI DML6TAS DML6TAS DN OPI-1002 DML6TAS MI TT12KOD DML6TAS MN P53 messenger RNA (TP53 mRNA) DML6TAS MT DTT DML6TAS RN 2011 Pipeline of Quark Pharm. DML6TAS RU http://www.quarkpharma.com/qbi-en/home/homepage/ DM1IBRT DI DM1IBRT DM1IBRT DN OPN-305 DM1IBRT MI TTY7ZHS DM1IBRT MN Toll-like receptor 2 (TLR2) DM1IBRT MT DTT DM1IBRT RN Treatment with OPN-305, a humanized anti-Toll-Like receptor-2 antibody, reduces myocardial ischemia/reperfusion injury in pigs. Circ Cardiovasc Interv. 2012 Apr;5(2):279-87. DM1IBRT RU https://pubmed.ncbi.nlm.nih.gov/22354933 DMYG1ZQ DI DMYG1ZQ DMYG1ZQ DN OPNT001 DMYG1ZQ MI TTKWM86 DMYG1ZQ MN Opioid receptor mu (MOP) DMYG1ZQ MT DTT DMYG1ZQ MA Antagonist DMYG1ZQ RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMYG1ZQ RU http://phrma-docs.phrma.org/files/dmfile/MID_Mental-Illness-2017-Drug-List_Final.pdf DM16RIC DI DM16RIC DM16RIC DN Oprozomib DM16RIC MI TTU7ZMG DM16RIC MN Proteasome (PS) DM16RIC MT DTT DM16RIC MA Modulator DM16RIC RN A novel orally active proteasome inhibitor ONX 0912 triggers in vitro and in vivo cytotoxicity in multiple myeloma. Blood. 2010 Dec 2;116(23):4906-15. DM16RIC RU https://pubmed.ncbi.nlm.nih.gov/20805366 DMS4XFI DI DMS4XFI DMS4XFI DN OPT-302 DMS4XFI MI TT0QUFV DMS4XFI MN Vascular endothelial growth factor C (VEGFC) DMS4XFI MT DTT DMS4XFI MA Inhibitor DMS4XFI RN Clinical pipeline report, company report or official report of Opthea. DMS4XFI RU https://opthea.com/ DMS4XFI DI DMS4XFI DMS4XFI DN OPT-302 DMS4XFI MI TTOM5H4 DMS4XFI MN Vascular endothelial growth factor D (VEGFD) DMS4XFI MT DTT DMS4XFI MA Inhibitor DMS4XFI RN Clinical pipeline report, company report or official report of Opthea. DMS4XFI RU https://opthea.com/ DMR3P98 DI DMR3P98 DMR3P98 DN ORG 34517/34850 DMR3P98 MI TTYRL6O DMR3P98 MN Glucocorticoid receptor (NR3C1) DMR3P98 MT DTT DMR3P98 MA Antagonist DMR3P98 RN Novel drugs and therapeutic targets for severe mood disorders. Neuropsychopharmacology. 2008 Aug;33(9):2080-92. DMR3P98 RU https://pubmed.ncbi.nlm.nih.gov/18172433 DMR3P98 DI DMR3P98 DMR3P98 DN ORG 34517/34850 DMR3P98 MI TTBFROQ DMR3P98 MN S-adenosylmethionine decarboxylase proenzyme (AMD1) DMR3P98 MT DTT DMR3P98 MA Inhibitor DMR3P98 RN A phase I study of a new polyamine biosynthesis inhibitor, SAM486A, in cancer patients with solid tumours. Br J Cancer. 2000 Sep;83(5):594-601. DMR3P98 RU https://pubmed.ncbi.nlm.nih.gov/10944598 DMAWXJT DI DMAWXJT DMAWXJT DN ORG-13011 DMAWXJT MI TTSQIFT DMAWXJT MN 5-HT 1A receptor (HTR1A) DMAWXJT MT DTT DMAWXJT MA Antagonist DMAWXJT RN Antagonism of the 5-HT1A receptor stimulus in a conditioned taste aversion procedure. Eur Neuropsychopharmacol. 1999 Jun;9(4):345-9. DMAWXJT RU https://pubmed.ncbi.nlm.nih.gov/10422896 DMWN2EC DI DMWN2EC DMWN2EC DN ORG-25935 DMWN2EC MI TTHJTF7 DMWN2EC MN Glycine transporter GlyT-1 (SLC6A9) DMWN2EC MT DTT DMWN2EC MA Inhibitor DMWN2EC RN The selective glycine uptake inhibitor org 25935 as an adjunctive treatment to atypical antipsychotics in predominant persistent negative symptoms of schizophrenia: results from the GIANT trial. J Clin Psychopharmacol. 2014 Apr;34(2):190-8. DMWN2EC RU https://pubmed.ncbi.nlm.nih.gov/24525661 DMDZ4R2 DI DMDZ4R2 DMDZ4R2 DN Org-30029 DMDZ4R2 MI TTZCG4L DMDZ4R2 MN Phosphodiesterase 3 (PDE3) DMDZ4R2 MT DTT DMDZ4R2 MA Modulator DMDZ4R2 RN Effects of the positive inotropic agent Org 30029 on developed force and aequorin light transients in intact canine ventricular myocardium. Circ Res. 1993 Mar;72(3):597-606. DMDZ4R2 RU https://pubmed.ncbi.nlm.nih.gov/8431987 DMIO59F DI DMIO59F DMIO59F DN ORG-34517 DMIO59F MI TTYRL6O DMIO59F MN Glucocorticoid receptor (NR3C1) DMIO59F MT DTT DMIO59F MA Antagonist DMIO59F RN Differential effects of the new glucocorticoid receptor antagonist ORG 34517 and RU486 (mifepristone) on glucocorticoid receptor nuclear translocation in the AtT20 cell line. Ann N Y Acad Sci. 2008 Dec;1148:536-41. DMIO59F RU https://pubmed.ncbi.nlm.nih.gov/19120154 DM8ARQW DI DM8ARQW DM8ARQW DN ORM-12741 DM8ARQW MI TT2NUT5 DM8ARQW MN Adrenergic receptor alpha-2C (ADRA2C) DM8ARQW MT DTT DM8ARQW MA Antagonist DM8ARQW RN A double-blind, randomized, placebo-controlled crossover trial of the alpha2C-adrenoceptor antagonist ORM-12741 for prevention of cold-induced vasospasm in patients with systemic sclerosis. Rheumatology (Oxford). 2014 May;53(5):948-52. DM8ARQW RU https://pubmed.ncbi.nlm.nih.gov/24489014 DMRIO6D DI DMRIO6D DMRIO6D DN ORMD-0901 DMRIO6D MI TTVIMDE DMRIO6D MN Glucagon-like peptide 1 receptor (GLP1R) DMRIO6D MT DTT DMRIO6D MA Agonist DMRIO6D RN Novel glucagon-like peptide-1 analog delivered orally reduces postprandial glucose excursions in porcine and canine models. J Diabetes Sci Technol. 2010 Nov 1;4(6):1516-23. DMRIO6D RU https://pubmed.ncbi.nlm.nih.gov/21129350 DM1EK5D DI DM1EK5D DM1EK5D DN Ortataxel DM1EK5D MI DTI7UX6 DM1EK5D MN Breast cancer resistance protein (ABCG2) DM1EK5D MT DTP DM1EK5D MA Substrate DM1EK5D RN Mammalian drug efflux transporters of the ATP binding cassette (ABC) family in multidrug resistance: A review of the past decade. Cancer Lett. 2016 Jan 1;370(1):153-64. DM1EK5D RU http://www.ncbi.nlm.nih.gov/pubmed/26499806 DM1EK5D DI DM1EK5D DM1EK5D DN Ortataxel DM1EK5D MI TT0JLSD DM1EK5D MN Multidrug resistance protein (MDR) DM1EK5D MT DTT DM1EK5D MA Modulator DM1EK5D RN Clinical pipeline report, company report or official report of Spectrum Phamaceuticals (2009). DM1EK5D RU http://www.spectrumpharm.com/products_Spectrum.html DM1EK5D DI DM1EK5D DM1EK5D DN Ortataxel DM1EK5D MI TTF8CQI DM1EK5D MN Tumor necrosis factor (TNF) DM1EK5D MT DTT DM1EK5D MA Inhibitor DM1EK5D RN New developments in immunosuppressive therapy for heart transplantation. Expert Opin Emerg Drugs. 2009 Mar;14(1):1-21. DM1EK5D RU https://pubmed.ncbi.nlm.nih.gov/19265486 DMSO846 DI DMSO846 DMSO846 DN Orvepitant DMSO846 MI TTZPO1L DMSO846 MN Substance-P receptor (TACR1) DMSO846 MT DTT DMSO846 MA Antagonist DMSO846 RN Clinical pipeline report, company report or official report of GlaxoSmithKline (2009). DMSO846 RU http://www.gsk.com/investors/product_pipeline/docs/gsk-pipeline-feb09.pdf DMJX3O8 DI DMJX3O8 DMJX3O8 DN OSI-027 DMJX3O8 MI TTCJG29 DMJX3O8 MN Serine/threonine-protein kinase mTOR (mTOR) DMJX3O8 MT DTT DMJX3O8 MA Inhibitor DMJX3O8 RN Targeting the phosphoinositide 3-kinase pathway in cancer. Nat Rev Drug Discov. 2009 Aug;8(8):627-44. DMJX3O8 RU https://pubmed.ncbi.nlm.nih.gov/19644473 DMBVI6E DI DMBVI6E DMBVI6E DN Ostabolin-C DMBVI6E MI TT6F7GZ DMBVI6E MN Parathyroid hormone (PTH) DMBVI6E MT DTT DMBVI6E MA Modulator DMBVI6E RN ZT-031, a cyclized analog of parathyroid hormone(1-31) for the potential treatment of osteoporosis. IDrugs. 2008 Nov;11(11):827-40. DMBVI6E RU https://www.ncbi.nlm.nih.gov/pubmed/18988128 DMHKIOF DI DMHKIOF DMHKIOF DN OT551 DMHKIOF MI TTA6ZN2 DMHKIOF MN Nuclear factor erythroid 2-related factor 2 (Nrf2) DMHKIOF MT DTT DMHKIOF MA Activator DMHKIOF RN Nitroxide pharmaceutical development for age-related degeneration and disease. Front Genet. 2015 Nov 6;6:325. DMHKIOF RU https://pubmed.ncbi.nlm.nih.gov/26594225 DMTNOXQ DI DMTNOXQ DMTNOXQ DN OT-551 DMTNOXQ MI TTA6ZN2 DMTNOXQ MN Nuclear factor erythroid 2-related factor 2 (Nrf2) DMTNOXQ MT DTT DMTNOXQ MA Inhibitor DMTNOXQ RN New hope for dry AMD. Nat Rev Drug Discov. 2013 Jul;12(7):501-2. DMTNOXQ RU https://pubmed.ncbi.nlm.nih.gov/23812264 DMFNDBC DI DMFNDBC DMFNDBC DN Otelixizumab DMFNDBC MI TTUN7MC DMFNDBC MN T-cell surface glycoprotein CD3 (CD3) DMFNDBC MT DTT DMFNDBC MA Modulator DMFNDBC RN Low-dose otelixizumab anti-CD3 monoclonal antibody DEFEND-1 study: results of the randomized phase III study in recent-onset human type 1 diabetes.Diabetes Care.2014 Oct;37(10):2746-54. DMFNDBC RU https://www.ncbi.nlm.nih.gov/pubmed/25011949 DM1AQLW DI DM1AQLW DM1AQLW DN Otilimab DM1AQLW MI TTPZGYX DM1AQLW MN HUMAN colony-stimulating factor (GM-CSF) DM1AQLW MT DTT DM1AQLW MA Inhibitor DM1AQLW RN The anti-viral facet of anti-rheumatic drugs: Lessons from COVID-19. J Autoimmun. 2020 Apr 17:102468. DM1AQLW RU https://pubmed.ncbi.nlm.nih.gov/32317220 DMAZIND DI DMAZIND DMAZIND DN Otlertuzumab DMAZIND MI TTFCW29 DMAZIND MN Leukocyte antigen CD37 (CD37) DMAZIND MT DTT DMAZIND MA Inhibitor DMAZIND RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMAZIND RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DM5Q9RY DI DM5Q9RY DM5Q9RY DN OX-914 DM5Q9RY MI TTZ97H5 DM5Q9RY MN Phosphodiesterase 4A (PDE4A) DM5Q9RY MT DTT DM5Q9RY MA Inhibitor DM5Q9RY RN Orexo announces Phase IIa data on OX914 in rhinitis. Orexo. 24th March, 2009. DM5Q9RY RU http://feed.ne.cision.com/wpyfs/00/00/00/00/00/0E/79/F6/wkr0003.pdf DM5Q9RY DI DM5Q9RY DM5Q9RY DN OX-914 DM5Q9RY MI TTVIAT9 DM5Q9RY MN Phosphodiesterase 4B (PDE4B) DM5Q9RY MT DTT DM5Q9RY MA Inhibitor DM5Q9RY RN Orexo announces Phase IIa data on OX914 in rhinitis. Orexo. 24th March, 2009. DM5Q9RY RU http://feed.ne.cision.com/wpyfs/00/00/00/00/00/0E/79/F6/wkr0003.pdf DM5Q9RY DI DM5Q9RY DM5Q9RY DN OX-914 DM5Q9RY MI TTSKMI8 DM5Q9RY MN Phosphodiesterase 4D (PDE4D) DM5Q9RY MT DTT DM5Q9RY MA Inhibitor DM5Q9RY RN Orexo announces Phase IIa data on OX914 in rhinitis. Orexo. 24th March, 2009. DM5Q9RY RU http://feed.ne.cision.com/wpyfs/00/00/00/00/00/0E/79/F6/wkr0003.pdf DMBM47Z DI DMBM47Z DMBM47Z DN Oxazolidinones DMBM47Z MI TT38DW5 DMBM47Z MN Bacterial 16S ribosomal RNA (Bact 16S rRNA) DMBM47Z MT DTT DMBM47Z MA Inhibitor DMBM47Z RN Ribosomal RNA is the target for oxazolidinones, a novel class of translational inhibitors. RNA. 1999 Jul;5(7):939-46. DMBM47Z RU https://pubmed.ncbi.nlm.nih.gov/10411137 DMBM47Z DI DMBM47Z DMBM47Z DN Oxazolidinones DMBM47Z MI TTLFGBV DMBM47Z MN Bacterial 23S ribosomal RNA (Bact 23S rRNA) DMBM47Z MT DTT DMBM47Z MA Inhibitor DMBM47Z RN Ribosomal RNA is the target for oxazolidinones, a novel class of translational inhibitors. RNA. 1999 Jul;5(7):939-46. DMBM47Z RU https://pubmed.ncbi.nlm.nih.gov/10411137 DMSNL51 DI DMSNL51 DMSNL51 DN Oxfendazole DMSNL51 MI DTI7UX6 DMSNL51 MN Breast cancer resistance protein (ABCG2) DMSNL51 MT DTP DMSNL51 MA Substrate DMSNL51 RN Transport of anthelmintic benzimidazole drugs by breast cancer resistance protein (BCRP/ABCG2). Drug Metab Dispos. 2005 May;33(5):614-8. DMSNL51 RU http://www.ncbi.nlm.nih.gov/pubmed/15703302 DMC3PJS DI DMC3PJS DMC3PJS DN Oxytrex DMC3PJS MI TTN4QDT DMC3PJS MN Opioid receptor (OPR) DMC3PJS MT DTT DMC3PJS MA Modulator DMC3PJS RN Oxytrex: an oxycodone and ultra-low-dose naltrexone formulation. Expert Opin Investig Drugs. 2007 Aug;16(8):1277-83. DMC3PJS RU https://pubmed.ncbi.nlm.nih.gov/17685875 DMEGTH1 DI DMEGTH1 DMEGTH1 DN Ozarelix DMEGTH1 MI TT8R70G DMEGTH1 MN Gonadotropin-releasing hormone receptor (GNRHR) DMEGTH1 MT DTT DMEGTH1 MA Modulator DMEGTH1 RN Ozarelix, a fourth generation GnRH antagonist, induces apoptosis in hormone refractory androgen receptor negative prostate cancer cells modulating expression and activity of death receptors. Prostate. 2010 Sep 1;70(12):1340-9. DMEGTH1 RU https://pubmed.ncbi.nlm.nih.gov/20623634 DMEYQPN DI DMEYQPN DMEYQPN DN P-1736 DMEYQPN MI TTB8FUC DMEYQPN MN Free fatty acid receptor 1 (GPR40) DMEYQPN MT DTT DMEYQPN MA Modulator DMEYQPN RN Discovery of p1736, a novel antidiabetic compound that improves peripheral insulin sensitivity in mice models. PLoS One. 2013 Oct 23;8(10):e77946. DMEYQPN RU https://pubmed.ncbi.nlm.nih.gov/24194903 DMMJUHD DI DMMJUHD DMMJUHD DN P-276 DMMJUHD MI TTH6V3D DMMJUHD MN Cyclin-dependent kinase 1 (CDK1) DMMJUHD MT DTT DMMJUHD MA Inhibitor DMMJUHD RN P276-00, a novel cyclin-dependent inhibitor induces G1-G2 arrest, shows antitumor activity on cisplatin-resistant cells and significant in vivo efficacy in tumor models. Mol Cancer Ther. 2007 Mar;6(3):926-34. DMMJUHD RU https://pubmed.ncbi.nlm.nih.gov/17363487 DMMJUHD DI DMMJUHD DMMJUHD DN P-276 DMMJUHD MI TT0PG8F DMMJUHD MN Cyclin-dependent kinase 4 (CDK4) DMMJUHD MT DTT DMMJUHD MA Inhibitor DMMJUHD RN Liposarcoma: molecular genetics and therapeutics. Sarcoma. 2011;2011:483154. DMMJUHD RU https://pubmed.ncbi.nlm.nih.gov/21253554 DM9DJL2 DI DM9DJL2 DM9DJL2 DN P276-00 DM9DJL2 MI TTH6V3D DM9DJL2 MN Cyclin-dependent kinase 1 (CDK1) DM9DJL2 MT DTT DM9DJL2 MA Inhibitor DM9DJL2 RN Cell cycle kinases as therapeutic targets for cancer. Nat Rev Drug Discov. 2009 Jul;8(7):547-66. DM9DJL2 RU https://pubmed.ncbi.nlm.nih.gov/19568282 DM9DJL2 DI DM9DJL2 DM9DJL2 DN P276-00 DM9DJL2 MI TT0PG8F DM9DJL2 MN Cyclin-dependent kinase 4 (CDK4) DM9DJL2 MT DTT DM9DJL2 MA Inhibitor DM9DJL2 RN Cell cycle kinases as therapeutic targets for cancer. Nat Rev Drug Discov. 2009 Jul;8(7):547-66. DM9DJL2 RU https://pubmed.ncbi.nlm.nih.gov/19568282 DM9DJL2 DI DM9DJL2 DM9DJL2 DN P276-00 DM9DJL2 MI TT1LVF2 DM9DJL2 MN Cyclin-dependent kinase 9 (CDK9) DM9DJL2 MT DTT DM9DJL2 MA Inhibitor DM9DJL2 RN Cell cycle kinases as therapeutic targets for cancer. Nat Rev Drug Discov. 2009 Jul;8(7):547-66. DM9DJL2 RU https://pubmed.ncbi.nlm.nih.gov/19568282 DMW1OI6 DI DMW1OI6 DMW1OI6 DN P32/98 DMW1OI6 MI TTDIGC1 DMW1OI6 MN Dipeptidyl peptidase 4 (DPP-4) DMW1OI6 MT DTT DMW1OI6 MA Inhibitor DMW1OI6 RN Long-term treatment with the dipeptidyl peptidase IV inhibitor P32/98 causes sustained improvements in glucose tolerance, insulin sensitivity, hyperinsulinemia, and beta-cell glucose responsiveness in VDF (fa/fa) Zucker rats. Diabetes. 2002 Apr;51(4):943-50. DMW1OI6 RU https://pubmed.ncbi.nlm.nih.gov/11916911 DMCBEYH DI DMCBEYH DMCBEYH DN P54 DMCBEYH MI TTUIZKC DMCBEYH MN DNA-binding factor KBF1 (p105) DMCBEYH MT DTT DMCBEYH MA Modulator DMCBEYH RN Identification of p54(nrb) and the 14-3-3 Protein HS1 as TNF-alpha-inducible genes related to cell cycle control and apoptosis in human arterial endothelial cells. J Biochem Mol Biol. 2005 Jul 31;38(4):447-56. DMCBEYH RU https://pubmed.ncbi.nlm.nih.gov/16053712 DMG8NLI DI DMG8NLI DMG8NLI DN P-9808 DMG8NLI MI TTT0HW3 DMG8NLI MN Porphobilinogen deaminase (HMBS) DMG8NLI MT DTT DMG8NLI MA Modulator DMG8NLI RN Safety, pharmacokinetics and pharmocodynamics of recombinant human porphobilinogen deaminase in healthy subjects and asymptomatic carriers of the acute intermittent porphyria gene who have increased porphyrin precursor excretion. Clin Pharmacokinet. 2007;46(4):335-49. DMG8NLI RU https://pubmed.ncbi.nlm.nih.gov/17375984 DM3816P DI DM3816P DM3816P DN PAC-14028 DM3816P MI TTMI6F5 DM3816P MN Transient receptor potential cation channel V1 (TRPV1) DM3816P MT DTT DM3816P MA Antagonist DM3816P RN Development of PAC-14028, a novel transient receptor potential vanilloid type 1 (TRPV1) channel antagonist as a new drug for refractory skin diseases. Arch Pharm Res. 2012 Mar;35(3):393-6. DM3816P RU https://pubmed.ncbi.nlm.nih.gov/22477184 DMMIYZ7 DI DMMIYZ7 DMMIYZ7 DN Palifosfamide DMMIYZ7 MI TT6S2FE DMMIYZ7 MN DNA [cytosine-5]-methyltransferase 1 (DNMT1) DMMIYZ7 MT DTT DMMIYZ7 MA Inhibitor DMMIYZ7 RN Anticancer activity of stabilized palifosfamide in vivo: schedule effects, oral bioavailability, and enhanced activity with docetaxel and doxorubicin. Anticancer Drugs. 2012 Feb;23(2):173-84. DMMIYZ7 RU https://pubmed.ncbi.nlm.nih.gov/22027537 DMX8ZAQ DI DMX8ZAQ DMX8ZAQ DN Paliroden DMX8ZAQ MI TT9HLZ0 DMX8ZAQ MN Glutamate receptor AMPA 2 (GRIA2) DMX8ZAQ MT DTT DMX8ZAQ MA Modulator DMX8ZAQ RN Mechanism of inhibition of the GluA2 AMPA receptor channel opening by talampanel and its enantiomer: the stereochemistry of the 4-methyl group on the diazepine ring of 2,3-benzodiazepine derivatives.ACS Chem Neurosci.2013 Apr 17;4(4):635-44. DMX8ZAQ RU https://www.ncbi.nlm.nih.gov/pubmed/23402301 DMAZ460 DI DMAZ460 DMAZ460 DN Pankomab-GEX DMAZ460 MI TTBHFYQ DMAZ460 MN Mucin-1 (MUC1) DMAZ460 MT DTT DMAZ460 RN Staining of MUC1 in ovarian cancer tissues with PankoMab-GEX detecting the tumour-associated epitope, TA-MUC1, as compared to antibodies HMFG-1 and 115D8. Histol Histopathol. 2013 Feb;28(2):239-44. DMAZ460 RU https://pubmed.ncbi.nlm.nih.gov/23275306 DMV27SP DI DMV27SP DMV27SP DN Panobacumab DMV27SP MI TT4ESMB DMV27SP MN Pseudomonas Lipopolysaccharide (Pseudo LPS) DMV27SP MT DTT DMV27SP MA Modulator DMV27SP RN Antibacterial antibodies gain traction. Nat Rev Drug Discov. 2015 Nov;14(11):737-8. DMV27SP RU https://www.ncbi.nlm.nih.gov/pubmed/26514853 DMPO4M1 DI DMPO4M1 DMPO4M1 DN Paquinimod DMPO4M1 MI TT0TMQG DMPO4M1 MN Calgranulin B (S100A9) DMPO4M1 MT DTT DMPO4M1 MA Inhibitor DMPO4M1 RN Prophylactic treatment with S100A9 inhibitor paquinimod reduces pathology in experimental collagenase-induced osteoarthritis. Ann Rheum Dis. 2015 Dec;74(12):2254-8. DMPO4M1 RU https://pubmed.ncbi.nlm.nih.gov/25969431 DMD275X DI DMD275X DMD275X DN Pardoprunox DMD275X MI TTEX248 DMD275X MN Dopamine D2 receptor (D2R) DMD275X MT DTT DMD275X MA Agonist DMD275X RN Novel drugs and therapeutic targets for severe mood disorders. Neuropsychopharmacology. 2008 Aug;33(9):2080-92. DMD275X RU https://pubmed.ncbi.nlm.nih.gov/18172433 DM4N7BT DI DM4N7BT DM4N7BT DN Paritaprevir DM4N7BT MI DTUGYRD DM4N7BT MN P-glycoprotein 1 (ABCB1) DM4N7BT MT DTP DM4N7BT MA Substrate DM4N7BT RN Tarascon Pocket Pharmacopoeia 2018 Classic Shirt-Pocket Edition. DM4N7BT RU https://books.google.com/books?id=0gBRDwAAQBAJ&pg=PP37&lpg=PP37&dq=Methylergonovine+transporter+uptake+efflex&source=bl&ots=cUTe_ppsmZ&sig=ACfU3U3E_YqrDg0CNEuj8K-7lci47HAnrg&hl=zh-CN&sa=X&ved=2ahUKEwjnj-Dk7d7iAhUsK6YKHd5DBDkQ6AEwEnoECAgQAQ#v=onepage&q&f=false DMYBIFS DI DMYBIFS DMYBIFS DN Parsaclisib DMYBIFS MI TTGBPJE DMYBIFS MN PI3-kinase delta (PIK3CD) DMYBIFS MT DTT DMYBIFS MA Inhibitor DMYBIFS RN Parsaclisib, a potent and highly selective PI3K inhibitor, in patients with relapsed or refractory B-cell malignancies. Blood. 2019 Apr 18;133(16):1742-1752. DMYBIFS RU https://pubmed.ncbi.nlm.nih.gov/30803990 DMCQBFT DI DMCQBFT DMCQBFT DN Parthenolide DMCQBFT MI TTJ3E9X DMCQBFT MN Inhibitor of nuclear factor kappa-B kinase beta (IKKB) DMCQBFT MT DTT DMCQBFT MA Inhibitor DMCQBFT RN The anti-inflammatory natural product parthenolide from the medicinal herb Feverfew directly binds to and inhibits IkappaB kinase. Chem Biol. 2001 Aug;8(8):759-66. DMCQBFT RU https://pubmed.ncbi.nlm.nih.gov/11514225 DMCQBFT DI DMCQBFT DMCQBFT DN Parthenolide DMCQBFT MI TTSXVID DMCQBFT MN Nuclear factor NF-kappa-B (NFKB) DMCQBFT MT DTT DMCQBFT MA Inhibitor DMCQBFT RN Hypoxia-induced neutrophil survival is mediated by HIF-1alpha-dependent NF-kappaB activity. J Exp Med. 2005 Jan 3;201(1):105-15. DMCQBFT RU https://pubmed.ncbi.nlm.nih.gov/15630139 DMU3XJP DI DMU3XJP DMU3XJP DN Pascolizumab DMU3XJP MI TTLGTKB DMU3XJP MN Interleukin-4 (IL4) DMU3XJP MT DTT DMU3XJP MA Modulator DMU3XJP RN The potential of biologics for the treatment of asthma. Nat Rev Drug Discov. 2012 Dec;11(12):958-72. DMU3XJP RU https://www.ncbi.nlm.nih.gov/pubmed/23197041 DM2NJYC DI DM2NJYC DM2NJYC DN Patidegib DM2NJYC MI TT4LXBC DM2NJYC MN Hedgehog signaling pathway (HS pathway) DM2NJYC MT DTT DM2NJYC MA Inhibitor DM2NJYC RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DM2NJYC RU http://phrma-docs.phrma.org/files/dmfile/MID_Skin_Diseases_2018_9_FINAL.pdf DMU0812 DI DMU0812 DMU0812 DN PAZ-320 DMU0812 MI TTXWASR DMU0812 MN Intestinal maltase-glucoamylase (MGAM) DMU0812 MT DTT DMU0812 MA Modulator DMU0812 RN Treatment With Novel Galactomannan Derivative Reduces 2-Hour Postprandial Glucose Excursions in Individuals With Type 2 Diabetes Treated With Oral Medications and/or Insulin. J Diabetes Sci Technol. 2014 September; 8(5): 1018-1022. DMU0812 RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4455361/ DMVJD2W DI DMVJD2W DMVJD2W DN Pazopanib + Tyverb/Tykerb DMVJD2W MI TTGKNB4 DMVJD2W MN Epidermal growth factor receptor (EGFR) DMVJD2W MT DTT DMVJD2W MA Inhibitor DMVJD2W RN Clinical pipeline report, company report or official report of GlaxoSmithKline (2009). DMVJD2W RU http://www.gsk.com/investors/product_pipeline/docs/gsk-pipeline-feb09.pdf DMVJD2W DI DMVJD2W DMVJD2W DN Pazopanib + Tyverb/Tykerb DMVJD2W MI TT6EO5L DMVJD2W MN Erbb2 tyrosine kinase receptor (HER2) DMVJD2W MT DTT DMVJD2W MA Inhibitor DMVJD2W RN Clinical pipeline report, company report or official report of GlaxoSmithKline (2009). DMVJD2W RU http://www.gsk.com/investors/product_pipeline/docs/gsk-pipeline-feb09.pdf DMZCI04 DI DMZCI04 DMZCI04 DN PB-1023 DMZCI04 MI TT0NUFM DMZCI04 MN Glucagon (GCG) DMZCI04 MT DTT DMZCI04 MA Agonist DMZCI04 RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMZCI04 RU http://phrma-docs.phrma.org/files/dmfile/mid-diabetes-drug-list.pdf DMZCI04 DI DMZCI04 DMZCI04 DN PB-1023 DMZCI04 MI TTVIMDE DMZCI04 MN Glucagon-like peptide 1 receptor (GLP1R) DMZCI04 MT DTT DMZCI04 MA Modulator DMZCI04 RN On-target Effects of GLP-1 Receptor Agonists on Thyroid C-cells in Rats and Mice. Toxicol Pathol February 2013 vol. 41 no. 2 303-309. DMZCI04 RU http://tpx.sagepub.com/content/41/2/303.full DM8MJ3F DI DM8MJ3F DM8MJ3F DN PB1046 DM8MJ3F MI TT4O5P0 DM8MJ3F MN Helodermin-preferring VIP receptor (VIPR2) DM8MJ3F MT DTT DM8MJ3F MA Agonist DM8MJ3F RN Clinical pipeline report, company report or official report of PhaseBio Pharmaceuticals. DM8MJ3F RU http://phasebio.com/clinical-development-pipeline/vasomera/ DM05WIU DI DM05WIU DM05WIU DN PBI-05204 DM05WIU MI TTQ38E9 DM05WIU MN Sodium/potassium-transporting ATPase (SPT ATPase) DM05WIU MT DTT DM05WIU MA Inhibitor DM05WIU RN First-in-human study of pbi-05204, an oleander-derived inhibitor of akt, fgf-2, nf- beta and p70s6k, in patients with advanced solid tumors. Invest New Drugs. 2014 Dec;32(6):1204-12. DM05WIU RU https://pubmed.ncbi.nlm.nih.gov/24919855 DMPXK27 DI DMPXK27 DMPXK27 DN PBI-4050 DMPXK27 MI TTB8FUC DMPXK27 MN Free fatty acid receptor 1 (GPR40) DMPXK27 MT DTT DMPXK27 MA Agonist DMPXK27 RN Phase 2 clinical trial of PBI-4050 in patients with idiopathic pulmonary fibrosis. Eur Respir J. 2019 Mar 18;53(3):1800663. DMPXK27 RU https://pubmed.ncbi.nlm.nih.gov/30578394 DMPXK27 DI DMPXK27 DMPXK27 DN PBI-4050 DMPXK27 MI TTG0MQD DMPXK27 MN Inflammation-related GPCR EX33 (GPR84) DMPXK27 MT DTT DMPXK27 MA Antagonist DMPXK27 RN Phase 2 clinical trial of PBI-4050 in patients with idiopathic pulmonary fibrosis. Eur Respir J. 2019 Mar 18;53(3):1800663. DMPXK27 RU https://pubmed.ncbi.nlm.nih.gov/30578394 DMKWGS1 DI DMKWGS1 DMKWGS1 DN PBT-2 DMKWGS1 MI TTS87KH DMKWGS1 MN Microtubule-associated protein tau (MAPT) DMKWGS1 MT DTT DMKWGS1 MA Modulator DMKWGS1 RN PBT2 rapidly improves cognition in Alzheimer's Disease: additional phase II analyses. J Alzheimers Dis. 2010;20(2):509-16. DMKWGS1 RU https://pubmed.ncbi.nlm.nih.gov/20164561 DMYRIHZ DI DMYRIHZ DMYRIHZ DN PCL-016 DMYRIHZ MI TT3J1EK DMYRIHZ MN Zinc finger protein (ZNF) DMYRIHZ MT DTT DMYRIHZ MA Modulator DMYRIHZ RN US patent application no. 2005,0239,723, Compositions and methods useful for treatment of acne. DMYRIHZ RU http://www.google.com/patents/US20050239723 DMYFRTB DI DMYFRTB DMYFRTB DN PCM-075 DMYFRTB MI TTIYVQP DMYFRTB MN Polo-like kinase 1 (PLK1) DMYFRTB MT DTT DMYFRTB MA Inhibitor DMYFRTB RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMYFRTB RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DMUHDX3 DI DMUHDX3 DMUHDX3 DN PC-SOD DMUHDX3 MI TT6RVLG DMUHDX3 MN Superoxide dismutase Cu-Zn (SOD Cu-Zn) DMUHDX3 MT DTT DMUHDX3 MA Modulator DMUHDX3 RN A lecithinized superoxide dismutase (PC-SOD) improves ulcerative colitis DMUHDX3 RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2659364 DM27D4J DI DM27D4J DM27D4J DN PD-0325901 DM27D4J MI TTROQ37 DM27D4J MN MAPK/ERK kinase kinase (MAP3K) DM27D4J MT DTT DM27D4J MA Modulator DM27D4J RN MEK and the inhibitors: from bench to bedside. J Hematol Oncol. 2013; 6: 27. DM27D4J RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3626705/ DMXAH4G DI DMXAH4G DMXAH4G DN PD-143188 DMXAH4G MI TTEX248 DMXAH4G MN Dopamine D2 receptor (D2R) DMXAH4G MT DTT DMXAH4G MA Modulator DMXAH4G RN Anxiolytic effects of dopamine receptor ligands: I. Involvement of dopamine autoreceptors. Life Sci. 1998;62(7):649-63. DMXAH4G RU https://pubmed.ncbi.nlm.nih.gov/9472724 DMWVBTQ DI DMWVBTQ DMWVBTQ DN PD-145065 DMWVBTQ MI TTKRD0G DMWVBTQ MN Endothelin A receptor (EDNRA) DMWVBTQ MT DTT DMWVBTQ MA Modulator DMWVBTQ RN Reversal of established responses to endothelin-1 in vivo and in vitro by the endothelin receptor antagonists, BQ-123 and PD 145065. Br J Pharmacol. 1994 May;112(1):207-13. DMWVBTQ RU https://pubmed.ncbi.nlm.nih.gov/8032643 DMWVBTQ DI DMWVBTQ DMWVBTQ DN PD-145065 DMWVBTQ MI TT3ZTGU DMWVBTQ MN Endothelin B receptor (EDNRB) DMWVBTQ MT DTT DMWVBTQ MA Modulator DMWVBTQ RN Reversal of established responses to endothelin-1 in vivo and in vitro by the endothelin receptor antagonists, BQ-123 and PD 145065. Br J Pharmacol. 1994 May;112(1):207-13. DMWVBTQ RU https://pubmed.ncbi.nlm.nih.gov/8032643 DMPW28M DI DMPW28M DMPW28M DN PD-200390 DMPW28M MI TT729IR DMPW28M MN Voltage-gated calcium channel alpha Cav3.1 (CACNA1G) DMPW28M MT DTT DMPW28M MA Modulator DMPW28M RN Pfizer. Product Development Pipeline. March 31 2009. DMPW28M RU http://media.pfizer.com/files/research/pipeline/2009_0331/pipeline_2009_0331.pdf DM6F5EV DI DM6F5EV DM6F5EV DN PD-360324 DM6F5EV MI TT731LW DM6F5EV MN Colony stimulating factor-1 receptor (CSF-1R) DM6F5EV MT DTT DM6F5EV MA Modulator DM6F5EV RN Monoclonal antibody against macrophage colony-stimulating factor suppresses circulating monocytes and tissue macrophage function but does not alter cell infiltration/activation in cutaneous lesions or clinical outcomes in patients with cutaneous lupus erythematosus.Clin Exp Immunol.2016 Feb;183(2):258-70. DM6F5EV RU https://www.ncbi.nlm.nih.gov/pubmed/26376111 DMGP9VN DI DMGP9VN DMGP9VN DN PDC-1421 DMGP9VN MI TTAWNKZ DMGP9VN MN Norepinephrine transporter (NET) DMGP9VN MT DTT DMGP9VN MA Inhibitor DMGP9VN RN Clinical pipeline report, company report or official report of BioInvent. DMGP9VN RU https://www.biolite.com.tw/tw/medicine/bli1005.html DM6OC53 DI DM6OC53 DM6OC53 DN PDX-101 DM6OC53 MI DE4LYSA DM6OC53 MN Cytochrome P450 3A4 (CYP3A4) DM6OC53 MT DME DM6OC53 MA Metabolism DM6OC53 RN Glucuronidation by UGT1A1 is the dominant pathway of the metabolic disposition of belinostat in liver cancer patients. PLoS One. 2013;8(1):e54522. DM6OC53 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=23382909 DM6OC53 DI DM6OC53 DM6OC53 DN PDX-101 DM6OC53 MI TTBH0VX DM6OC53 MN Histone deacetylase (HDAC) DM6OC53 MT DTT DM6OC53 MA Modulator DM6OC53 RN Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41. DM6OC53 RU https://www.ncbi.nlm.nih.gov/pubmed/15950434 DM6OC53 DI DM6OC53 DM6OC53 DN PDX-101 DM6OC53 MI DEYGVN4 DM6OC53 MN UDP-glucuronosyltransferase 1A1 (UGT1A1) DM6OC53 MT DME DM6OC53 MA Metabolism DM6OC53 RN Effects of UGT1A1 genotype on the pharmacokinetics, pharmacodynamics, and toxicities of belinostat administered by 48-hour continuous infusion in patients with cancer. J Clin Pharmacol. 2016 Apr;56(4):461-73. DM6OC53 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=26313268 DMFL96Z DI DMFL96Z DMFL96Z DN Pegamotecan DMFL96Z MI TTGTQHC DMFL96Z MN DNA topoisomerase I (TOP1) DMFL96Z MT DTT DMFL96Z MA Inhibitor DMFL96Z RN A phase II study of pegylated-camptothecin (pegamotecan) in the treatment of locally advanced and metastatic gastric and gastro-oesophageal junction adenocarcinoma. Cancer Chemother Pharmacol. 2009 Jan;63(2):363-70. DMFL96Z RU https://pubmed.ncbi.nlm.nih.gov/18398613 DMPD3X6 DI DMPD3X6 DMPD3X6 DN Pegmusirudin DMPD3X6 MI TT6L509 DMPD3X6 MN Coagulation factor IIa (F2) DMPD3X6 MT DTT DMPD3X6 MA Modulator DMPD3X6 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2362). DMPD3X6 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2362 DM26YJ1 DI DM26YJ1 DM26YJ1 DN PEGPH20 DM26YJ1 MI TTXFI1K DM26YJ1 MN Hyaluronidase (HYAL) DM26YJ1 MT DTT DM26YJ1 MA Modulator DM26YJ1 RN Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41. DM26YJ1 RU https://www.ncbi.nlm.nih.gov/pubmed/15950434 DMX9ZM4 DI DMX9ZM4 DMX9ZM4 DN PEG-SN38 DMX9ZM4 MI DE4LYSA DMX9ZM4 MN Cytochrome P450 3A4 (CYP3A4) DMX9ZM4 MT DME DMX9ZM4 MA Metabolism DMX9ZM4 RN Phase I dose-escalation study of EZN-2208 (PEG-SN38), a novel conjugate of poly(ethylene) glycol and SN38, administered weekly in patients with advanced cancer. Cancer Chemother Pharmacol. 2013 Jun;71(6):1499-506. DMX9ZM4 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=23543270 DMX9ZM4 DI DMX9ZM4 DMX9ZM4 DN PEG-SN38 DMX9ZM4 MI TTGTQHC DMX9ZM4 MN DNA topoisomerase I (TOP1) DMX9ZM4 MT DTT DMX9ZM4 MA Inhibitor DMX9ZM4 RN EZN-2208 (PEG-SN38) overcomes ABCG2-mediated topotecan resistance in BRCA1-deficient mouse mammary tumors. PLoS One. 2012;7(9):e45248. DMX9ZM4 RU https://pubmed.ncbi.nlm.nih.gov/23028879 DMTDANB DI DMTDANB DMTDANB DN Pegsunercept DMTDANB MI TTF8CQI DMTDANB MN Tumor necrosis factor (TNF) DMTDANB MT DTT DMTDANB MA Inhibitor DMTDANB RN Diabetes-enhanced tumor necrosis factor-alpha production promotes apoptosis and the loss of retinal microvascular cells in type 1 and type 2 models of diabetic retinopathy. Am J Pathol. 2008 May;172(5):1411-8. DMTDANB RU https://pubmed.ncbi.nlm.nih.gov/18403591 DMBPJ9U DI DMBPJ9U DMBPJ9U DN PEGylated pitrakinra DMBPJ9U MI TT0GVCH DMBPJ9U MN Interleukin-13 (IL13) DMBPJ9U MT DTT DMBPJ9U MA Modulator DMBPJ9U RN The potential of biologics for the treatment of asthma. Nat Rev Drug Discov. 2012 Dec;11(12):958-72. DMBPJ9U RU https://www.ncbi.nlm.nih.gov/pubmed/23197041 DMBPJ9U DI DMBPJ9U DMBPJ9U DN PEGylated pitrakinra DMBPJ9U MI TTLGTKB DMBPJ9U MN Interleukin-4 (IL4) DMBPJ9U MT DTT DMBPJ9U MA Modulator DMBPJ9U RN The potential of biologics for the treatment of asthma. Nat Rev Drug Discov. 2012 Dec;11(12):958-72. DMBPJ9U RU https://www.ncbi.nlm.nih.gov/pubmed/23197041 DMOMN31 DI DMOMN31 DMOMN31 DN PEITC DMOMN31 MI DTI7UX6 DMOMN31 MN Breast cancer resistance protein (ABCG2) DMOMN31 MT DTP DMOMN31 MA Substrate DMOMN31 RN A prediction model of substrates and non-substrates of breast cancer resistance protein (BCRP) developed by GA-CG-SVM method. Comput Biol Med. 2011 Nov;41(11):1006-13. DMOMN31 RU https://doi.org/10.1016/j.compbiomed.2011.08.009 DMOMN31 DI DMOMN31 DMOMN31 DN PEITC DMOMN31 MI DE4ZHS1 DMOMN31 MN Glutathione S-transferase alpha-1 (GSTA1) DMOMN31 MT DME DMOMN31 MA Metabolism DMOMN31 RN Pharmacokinetics and pharmacodynamics of phenethyl isothiocyanate: implications in breast cancer prevention. AAPS J. 2014 Jul;16(4):705-13. DMOMN31 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=24821055 DMOMN31 DI DMOMN31 DMOMN31 DN PEITC DMOMN31 MI DTSYQGK DMOMN31 MN Multidrug resistance-associated protein 1 (ABCC1) DMOMN31 MT DTP DMOMN31 MA Substrate DMOMN31 RN Human intestinal transporter database: QSAR modeling and virtual profiling of drug uptake, efflux and interactions. Pharm Res. 2013 Apr;30(4):996-1007. DMOMN31 RU https://doi.org/10.1007/s11095-012-0935-x DMOMN31 DI DMOMN31 DMOMN31 DN PEITC DMOMN31 MI DTFI42L DMOMN31 MN Multidrug resistance-associated protein 2 (ABCC2) DMOMN31 MT DTP DMOMN31 MA Substrate DMOMN31 RN Transport of dietary phenethyl isothiocyanate is mediated by multidrug resistance protein 2 but not P-glycoprotein. Biochem Pharmacol. 2005 Aug 15;70(4):640-7. DMOMN31 RU https://doi.org/10.1016/j.bcp.2005.05.025 DMIW453 DI DMIW453 DMIW453 DN Pelitinib DMIW453 MI TTGKNB4 DMIW453 MN Epidermal growth factor receptor (EGFR) DMIW453 MT DTT DMIW453 MA Modulator DMIW453 RN EGFR tyrosine kinase inhibitor pelitinib regulates radiation-induced p65-dependent telomerase activation in squamous cell carcinoma.Radiat Res.2013 Mar;179(3):304-12. DMIW453 RU https://www.ncbi.nlm.nih.gov/pubmed/23379415 DMR6USG DI DMR6USG DMR6USG DN PELITREXOL DMR6USG MI TTEXB9Z DMR6USG MN Glycinamide ribonucleotide formyltransferase (GART) DMR6USG MT DTT DMR6USG MA Inhibitor DMR6USG RN Results of 2 phase I studies of intravenous (iv) pelitrexol (AG2037), a glycinamide ribonucleotide formyltransferase (GARFT) inhibitor, in patients (pts) with solid tumors. J Clin Oncol (Meeting Abstracts) July 2004 vol. 22 no. 14_suppl 3075. DMR6USG RU http://meeting.ascopubs.org/cgi/content/short/22/14_suppl/3075 DMGY5JC DI DMGY5JC DMGY5JC DN Pentacea DMGY5JC MI TTY6DTE DMGY5JC MN Carcinoembryonic antigen CEA (CD66e) DMGY5JC MT DTT DMGY5JC RN Antibody fragments: Hope and hype. MAbs. 2010 Jan-Feb; 2(1): 77-83. DMGY5JC RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2828581/ DMNU48O DI DMNU48O DMNU48O DN Peptide YY 3-36 DMNU48O MI TTVFJLX DMNU48O MN Peptide tyrosine tyrosine PYY (PYY) DMNU48O MT DTT DMNU48O MA Modulator DMNU48O RN Clinical pipeline report, company report or official report of Emisphere. DMNU48O RU http://ir.emisphere.com/releasedetail.cfm?releaseid=356364 DMFM6OU DI DMFM6OU DMFM6OU DN PerioPatch DMFM6OU MI TTHS7CM DMFM6OU MN Beta-glucuronidase (GUSB) DMFM6OU MT DTT DMFM6OU MA Modulator DMFM6OU RN Clinical pipeline report, company report or official report of Izun Pharmaceuticals. DMFM6OU RU http://izunpharma.com/products/periopatch/ DMNM4CK DI DMNM4CK DMNM4CK DN PF-00734200 DMNM4CK MI TTDIGC1 DMNM4CK MN Dipeptidyl peptidase 4 (DPP-4) DMNM4CK MT DTT DMNM4CK MA Modulator DMNM4CK RN Efficacy and safety of the dipeptidyl peptidase-4 inhibitor PF-734200 added to metformin in Type 2 diabetes.Diabet Med.2011 Apr;28(4):464-9. DMNM4CK RU https://www.ncbi.nlm.nih.gov/pubmed/21392067 DMJPE61 DI DMJPE61 DMJPE61 DN PF-02545920 DMJPE61 MI TTJW4LU DMJPE61 MN Phosphodiesterase 10A (PDE10) DMJPE61 MT DTT DMJPE61 MA Inhibitor DMJPE61 RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMJPE61 RU http://phrma-docs.phrma.org/sites/default/files/pdf/medicines-in-development-drug-list-rare-diseases.pdf DMTJWNE DI DMTJWNE DMTJWNE DN PF-03446962 DMTJWNE MI TTGYPTC DMTJWNE MN Activin receptor-like kinase-1 (ACVRL1) DMTJWNE MT DTT DMTJWNE MA Modulator DMTJWNE RN ALK1 as an emerging target for antiangiogenic therapy of cancer. Blood. 2011 June 30; 117(26): 6999-7006. DMTJWNE RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3143549/ DM826SW DI DM826SW DM826SW DN PF-04236921 DM826SW MI TTF6I40 DM826SW MN Interleukin (IL) DM826SW MT DTT DM826SW MA Inhibitor DM826SW RN US patent application no. 2010,0158,905, Combination therapy of arthritis with tranilast. DM826SW RU https://www.google.com/patents/US20100158905 DM826SW DI DM826SW DM826SW DN PF-04236921 DM826SW MI TTT1V78 DM826SW MN Interleukin-6 (IL6) DM826SW MT DTT DM826SW MA Inhibitor DM826SW RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DM826SW RU http://phrma-docs.phrma.org/files/dmfile/medicines-in-development-drug-list-autoimmune-diseases.pdf DMPRYU1 DI DMPRYU1 DMPRYU1 DN PF-04457845 DMPRYU1 MI TTDP1UC DMPRYU1 MN Fatty acid amide hydrolase (FAAH) DMPRYU1 MT DTT DMPRYU1 MA Inhibitor DMPRYU1 RN Discovery of PF-04457845: A Highly Potent, Orally Bioavailable, and Selective Urea FAAH Inhibitor. ACS Med Chem Lett. 2011 Feb 10;2(2):91-96. DMPRYU1 RU https://pubmed.ncbi.nlm.nih.gov/21666860 DMZMUIL DI DMZMUIL DMZMUIL DN PF-04518600 DMZMUIL MI TTL31H0 DMZMUIL MN OX40L receptor (CD134) DMZMUIL MT DTT DMZMUIL MA Agonist DMZMUIL RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMZMUIL RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DMA9MBR DI DMA9MBR DMA9MBR DN PF-04523655 DMA9MBR MI TT0AWFK DMA9MBR MN HIF-1 responsive protein RTP801 (DDIT4) DMA9MBR MT DTT DMA9MBR RN Teaming up to tackle RNAi delivery challenge. Nat Rev Drug Discov. 2009 Jul;8(7):525-6. DMA9MBR RU https://pubmed.ncbi.nlm.nih.gov/19568274 DMS610L DI DMS610L DMS610L DN PF-04691502 DMS610L MI TTHBTOP DMS610L MN PI3-kinase gamma (PIK3CG) DMS610L MT DTT DMS610L MA Modulator DMS610L RN PF-04691502, a potent and selective oral inhibitor of PI3K and mTOR kinases with antitumor activity.Mol Cancer Ther.2011 Nov;10(11):2189-99. DMS610L RU https://www.ncbi.nlm.nih.gov/pubmed/21750219 DMS610L DI DMS610L DMS610L DN PF-04691502 DMS610L MI TTCJG29 DMS610L MN Serine/threonine-protein kinase mTOR (mTOR) DMS610L MT DTT DMS610L MA Modulator DMS610L RN PF-04691502, a potent and selective oral inhibitor of PI3K and mTOR kinases with antitumor activity.Mol Cancer Ther.2011 Nov;10(11):2189-99. DMS610L RU https://www.ncbi.nlm.nih.gov/pubmed/21750219 DMQMF4O DI DMQMF4O DMQMF4O DN PF-04937319 DMQMF4O MI TTDLNGZ DMQMF4O MN Glucokinase (GCK) DMQMF4O MT DTT DMQMF4O MA Modulator DMQMF4O RN Two dose-ranging studies with PF-04937319, a systemic partial activator of glucokinase, as add-on therapy to metformin in adults with type 2 diabetes. Diabetes Obes Metab. 2015 Aug;17(8):751-9. DMQMF4O RU https://pubmed.ncbi.nlm.nih.gov/25885172 DMRAFBK DI DMRAFBK DMRAFBK DN PF-04958242 DMRAFBK MI TTAN6JD DMRAFBK MN Glutamate receptor AMPA (GRIA) DMRAFBK MT DTT DMRAFBK MA Activator DMRAFBK RN Antibodies and venom peptides: new modalities for ion channels. Nat Rev Drug Discov. 2019 May;18(5):339-357. DMRAFBK RU https://pubmed.ncbi.nlm.nih.gov/30728472 DM94NBE DI DM94NBE DM94NBE DN PF-04991532 DM94NBE MI TTDLNGZ DM94NBE MN Glucokinase (GCK) DM94NBE MT DTT DM94NBE MA Activator DM94NBE RN The hepatoselective glucokinase activator PF-04991532 ameliorates hyperglycemia without causing hepatic steatosis in diabetic rats. PLoS One. 2014 May 23;9(5):e97139. DM94NBE RU https://pubmed.ncbi.nlm.nih.gov/24858947 DMD74BJ DI DMD74BJ DMD74BJ DN PF-05089771 DMD74BJ MI TT4G2JS DMD74BJ MN Voltage-gated sodium channel alpha Nav1.7 (SCN9A) DMD74BJ MT DTT DMD74BJ MA Blocker DMD74BJ RN Primary erythromelalgia: a review. Orphanet J Rare Dis. 2015 Sep 30;10:127. DMD74BJ RU https://pubmed.ncbi.nlm.nih.gov/26419464 DMLQ3OK DI DMLQ3OK DMLQ3OK DN PF-05175157 DMLQ3OK MI TTY84UG DMLQ3OK MN Acetyl-CoA carboxylase 2 (ACACB) DMLQ3OK MT DTT DMLQ3OK MA Inhibitor DMLQ3OK RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1264). DMLQ3OK RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1264 DMPVQYR DI DMPVQYR DMPVQYR DN PF-05212377 DMPVQYR MI TTJS8PY DMPVQYR MN 5-HT 6 receptor (HTR6) DMPVQYR MT DTT DMPVQYR MA Antagonist DMPVQYR RN PF-05212377 Alzheimer's Disease (Phase 2). Pfizer. DMPVQYR RU http://www.alzforum.org/therapeutics/pf-05212377 DMBL3VD DI DMBL3VD DMBL3VD DN PF-05212384 DMBL3VD MI TTHBTOP DMBL3VD MN PI3-kinase gamma (PIK3CG) DMBL3VD MT DTT DMBL3VD MA Modulator DMBL3VD RN First-in-Human Study of PF-05212384 (PKI-587), a Small-Molecule, Intravenous, Dual Inhibitor of PI3K and mTOR in Patients with Advanced Cancer. Clin Cancer Res. 2015 Apr 15;21(8):1888-95. DMBL3VD RU https://pubmed.ncbi.nlm.nih.gov/25652454 DMBL3VD DI DMBL3VD DMBL3VD DN PF-05212384 DMBL3VD MI TTCJG29 DMBL3VD MN Serine/threonine-protein kinase mTOR (mTOR) DMBL3VD MT DTT DMBL3VD MA Modulator DMBL3VD RN First-in-Human Study of PF-05212384 (PKI-587), a Small-Molecule, Intravenous, Dual Inhibitor of PI3K and mTOR in Patients with Advanced Cancer. Clin Cancer Res. 2015 Apr 15;21(8):1888-95. DMBL3VD RU https://pubmed.ncbi.nlm.nih.gov/25652454 DMQLZOF DI DMQLZOF DMQLZOF DN PF-06252616 DMQLZOF MI TTSWPH8 DMQLZOF MN Growth/differentiation factor 8 (GDF-8) DMQLZOF MT DTT DMQLZOF RN Myostatin inhibitors as therapies for muscle wasting associated with cancer and other disorders. Curr Opin Support Palliat Care. 2013 November; 7(4): 352-360. DMQLZOF RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3819341/ DMUAOFM DI DMUAOFM DMUAOFM DN PF-06290510 DMUAOFM MI TTE6QWF DMUAOFM MN Staphylococcus Capsular polysaccharide CP5 (Stap-coc CP5) DMUAOFM MT DTT DMUAOFM RN ClinicalTrials.gov (NCT01364571) Evaluation of a Single Vaccination With One of Three Ascending Dose Levels of a 4-Antigen Staphylococcus Aureus Vaccine (SA4Ag) in Healthy Adults Aged 18 to <65 Years. U.S. National Institutes of Health. DMUAOFM RU https://clinicaltrials.gov/ct2/show/NCT01364571 DMUAOFM DI DMUAOFM DMUAOFM DN PF-06290510 DMUAOFM MI TT4SVB7 DMUAOFM MN Staphylococcus Capsular polysaccharide CP8 (Stap-coc CP8) DMUAOFM MT DTT DMUAOFM RN ClinicalTrials.gov (NCT01364571) Evaluation of a Single Vaccination With One of Three Ascending Dose Levels of a 4-Antigen Staphylococcus Aureus Vaccine (SA4Ag) in Healthy Adults Aged 18 to <65 Years. U.S. National Institutes of Health. DMUAOFM RU https://clinicaltrials.gov/ct2/show/NCT01364571 DMUAOFM DI DMUAOFM DMUAOFM DN PF-06290510 DMUAOFM MI TTWGZ64 DMUAOFM MN Staphylococcus Clumping factor A (Stap-coc ClfA) DMUAOFM MT DTT DMUAOFM RN ClinicalTrials.gov (NCT01364571) Evaluation of a Single Vaccination With One of Three Ascending Dose Levels of a 4-Antigen Staphylococcus Aureus Vaccine (SA4Ag) in Healthy Adults Aged 18 to <65 Years. U.S. National Institutes of Health. DMUAOFM RU https://clinicaltrials.gov/ct2/show/NCT01364571 DMUAOFM DI DMUAOFM DMUAOFM DN PF-06290510 DMUAOFM MI TTBWX8P DMUAOFM MN Staphylococcus Manganese transporter C (Stap-coc MntC) DMUAOFM MT DTT DMUAOFM RN ClinicalTrials.gov (NCT01364571) Evaluation of a Single Vaccination With One of Three Ascending Dose Levels of a 4-Antigen Staphylococcus Aureus Vaccine (SA4Ag) in Healthy Adults Aged 18 to <65 Years. U.S. National Institutes of Health. DMUAOFM RU https://clinicaltrials.gov/ct2/show/NCT01364571 DMN94QM DI DMN94QM DMN94QM DN PF-06291874 DMN94QM MI TT9O6WS DMN94QM MN Glucagon receptor (GCGR) DMN94QM MT DTT DMN94QM MA Antagonist DMN94QM RN Clinical pipeline report, company report or official report of pfizer. DMN94QM RU http://www.pfizer.com/sites/default/files/product-pipeline/110614_Pipeline_Update.pdf DMKM7EW DI DMKM7EW DMKM7EW DN PF-06463922 DMKM7EW MI TTPMQSO DMKM7EW MN ALK tyrosine kinase receptor (ALK) DMKM7EW MT DTT DMKM7EW MA Inhibitor DMKM7EW RN PF-06463922, an ALK/ROS1 Inhibitor, Overcomes Resistance to First and Second Generation ALK Inhibitors in Preclinical Models. Cancer Cell. 2015 Jul 13;28(1):70-81. DMKM7EW RU https://pubmed.ncbi.nlm.nih.gov/26144315 DM9S3P7 DI DM9S3P7 DM9S3P7 DN PF-06473871 DM9S3P7 MI TTIL516 DM9S3P7 MN CCN2 messenger RNA (CCN2 mRNA) DM9S3P7 MT DTT DM9S3P7 MA Inhibitor DM9S3P7 RN A Placebo-controlled Study of PF-06473871 (Anti-Connective Tissue Growth Factor Antisense Oligonucleotide) in Reducing Hypertrophic Skin Scarring. Plast Reconstr Surg Glob Open. 2018 Sep 6;6(9):e1861. DM9S3P7 RU https://pubmed.ncbi.nlm.nih.gov/30349773 DMMGSFV DI DMMGSFV DMMGSFV DN PF-06700841 DMMGSFV MI TT6DM01 DMMGSFV MN Janus kinase 1 (JAK-1) DMMGSFV MT DTT DMMGSFV MA Inhibitor DMMGSFV RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMMGSFV RU http://phrma-docs.phrma.org/files/dmfile/MID_Skin_Diseases_2018_9_FINAL.pdf DMMGSFV DI DMMGSFV DMMGSFV DN PF-06700841 DMMGSFV MI TTBYWP2 DMMGSFV MN TYK2 tyrosine kinase (TYK2) DMMGSFV MT DTT DMMGSFV MA Inhibitor DMMGSFV RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMMGSFV RU http://phrma-docs.phrma.org/files/dmfile/MID_Skin_Diseases_2018_9_FINAL.pdf DM8C1H4 DI DM8C1H4 DM8C1H4 DN PF-06823859 DM8C1H4 MI TT4TZ8J DM8C1H4 MN Interferon-beta (IFNB1) DM8C1H4 MT DTT DM8C1H4 MA Blocker DM8C1H4 RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DM8C1H4 RU http://phrma-docs.phrma.org/files/dmfile/MID_Skin_Diseases_2018_9_FINAL.pdf DM5H8V1 DI DM5H8V1 DM5H8V1 DN PF-06826647 DM5H8V1 MI TTBYWP2 DM5H8V1 MN TYK2 tyrosine kinase (TYK2) DM5H8V1 MT DTT DM5H8V1 MA Inhibitor DM5H8V1 RN Discovery of Tyrosine Kinase 2 (TYK2) Inhibitor (PF-06826647) for the Treatment of Autoimmune Diseases. J Med Chem. 2020 Nov 25;63(22):13561-13577. DM5H8V1 RU https://pubmed.ncbi.nlm.nih.gov/32787094 DM7EJ8S DI DM7EJ8S DM7EJ8S DN PF-06882961 DM7EJ8S MI TTVIMDE DM7EJ8S MN Glucagon-like peptide 1 receptor (GLP1R) DM7EJ8S MT DTT DM7EJ8S MA Agonist DM7EJ8S RN Differential GLP-1R Binding and Activation by Peptide and Non-peptide Agonists. Mol Cell. 2020 Nov 5;80(3):485-500.e7. DM7EJ8S RU https://pubmed.ncbi.nlm.nih.gov/33027691 DM8T6KQ DI DM8T6KQ DM8T6KQ DN PF-232798 DM8T6KQ MI TT2CEJG DM8T6KQ MN C-C chemokine receptor type 5 (CCR5) DM8T6KQ MT DTT DM8T6KQ MA Antagonist DM8T6KQ RN An imidazopiperidine series of CCR5 antagonists for the treatment of HIV: the discovery of N-{(1S)-1-(3-fluorophenyl)-3-[(3-endo)-3-(5-isobutyryl-2-methyl-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridin-1-yl)-8-azabicyclo[3.2.1]oct-8-yl]propyl}acetamide (PF-232798). J Med Chem. 2011 Jan 13;54(1):67-77. DM8T6KQ RU https://pubmed.ncbi.nlm.nih.gov/21128663 DMO02LU DI DMO02LU DMO02LU DN PF-3463275 DMO02LU MI TTHJTF7 DMO02LU MN Glycine transporter GlyT-1 (SLC6A9) DMO02LU MT DTT DMO02LU MA Inhibitor DMO02LU RN Glycine transporters as novel therapeutic targets in schizophrenia, alcohol dependence and pain. Nat Rev Drug Discov. 2013 Nov;12(11):866-85. DMO02LU RU https://pubmed.ncbi.nlm.nih.gov/24172334 DMC2FAL DI DMC2FAL DMC2FAL DN PF-3893787 DMC2FAL MI TTXJ178 DMC2FAL MN Histamine H4 receptor (H4R) DMC2FAL MT DTT DMC2FAL MA Antagonist DMC2FAL RN Challenges of drug discovery in novel target space. The discovery and evaluation of PF-3893787: a novel histamine H4 receptor antagonist. Bioorg Med Chem Lett. 2011 Nov 1;21(21):6596-602. DMC2FAL RU https://pubmed.ncbi.nlm.nih.gov/21920751 DM3DWKN DI DM3DWKN DM3DWKN DN PF-4191834 DM3DWKN MI TT2J34L DM3DWKN MN Arachidonate 5-lipoxygenase (5-LOX) DM3DWKN MT DTT DM3DWKN MA Inhibitor DM3DWKN RN Pharmacology of PF-4191834, a novel, selective non-redox 5-lipoxygenase inhibitor effective in inflammation and pain. J Pharmacol Exp Ther. 2010 Jul;334(1):294-301. DM3DWKN RU https://pubmed.ncbi.nlm.nih.gov/20378715 DM81D4I DI DM81D4I DM81D4I DN PF-4447943 DM81D4I MI TTZOEBC DM81D4I MN Phosphodiesterase 9 (PDE9) DM81D4I MT DTT DM81D4I MA Inhibitor DM81D4I RN A multicenter, double-blind, placebo-controlled trial of the PDE9A inhibitor, PF-04447943, in Alzheimer's disease. Curr Alzheimer Res. 2014;11(5):413-21. DM81D4I RU https://pubmed.ncbi.nlm.nih.gov/24801218 DML38VU DI DML38VU DML38VU DN PF-446687 DML38VU MI TTD0CIQ DML38VU MN Melanocortin receptor 4 (MC4R) DML38VU MT DTT DML38VU MA Modulator DML38VU RN Melanocortin Receptor Agonists Facilitate Oxytocin-Dependent Partner Preference Formation in the Prairie Vole. Neuropsychopharmacology. 2015 Jul;40(8):1856-65. DML38VU RU https://pubmed.ncbi.nlm.nih.gov/25652247 DM3YIKR DI DM3YIKR DM3YIKR DN PF-4523655 DM3YIKR MI TTVEOY6 DM3YIKR MN RTP801 messenger RNA (RTP801 mRNA) DM3YIKR MT DTT DM3YIKR RN DNA-damage-inducible transcript 4 (DDIT4; RTP801). SciBX 3(20); doi:10.1038/scibx.2010.629. May 20 2010 DM3YIKR RU http://www.nature.com/scibx/journal/v3/n20/full/scibx.2010.629.html DM24I0N DI DM24I0N DM24I0N DN PF-4878691 DM24I0N MI TTRJ1K4 DM24I0N MN Toll-like receptor 7 (TLR7) DM24I0N MT DTT DM24I0N MA Agonist DM24I0N RN The innate immune response, clinical outcomes, and ex vivo HCV antiviral efficacy of a TLR7 agonist (PF-4878691). Clin Pharmacol Ther. 2011 Jun;89(6):821-9. DM24I0N RU https://pubmed.ncbi.nlm.nih.gov/21451504 DM3C8GQ DI DM3C8GQ DM3C8GQ DN PF-489791 DM3C8GQ MI TTJ0IQB DM3C8GQ MN Phosphodiesterase 5A (PDE5A) DM3C8GQ MT DTT DM3C8GQ MA Inhibitor DM3C8GQ RN Highlights of the society for medicinesresearch symposium held december 10th 2009 at the national heart and lung institute, London, UK. Drugs of the Future 2010, 35(4): 349-358. DM3C8GQ RU https://www.smr.org.uk/smr/archive/pastmeetings/Downloads/SMR_Dec_09_Report.pdf DM0KRLJ DI DM0KRLJ DM0KRLJ DN PF-885706 DM0KRLJ MI TT07C3Y DM0KRLJ MN 5-HT 4 receptor (HTR4) DM0KRLJ MT DTT DM0KRLJ MA Agonist DM0KRLJ RN Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800025579) DM0KRLJ RU http://adisinsight.springer.com/drugs/800025579 DMF5YEN DI DMF5YEN DMF5YEN DN PG-102 DMF5YEN MI TTIJP3Q DMF5YEN MN TNF related activation protein (CD40LG) DMF5YEN MT DTT DMF5YEN MA Modulator DMF5YEN RN Induction of an altered CD40 signaling complex by an antagonistic human monoclonal antibody to CD40.J Immunol.2015 May 1;194(9):4319-27. DMF5YEN RU https://www.ncbi.nlm.nih.gov/pubmed/25795759 DMJTYO4 DI DMJTYO4 DMJTYO4 DN PGL-2 DMJTYO4 MI TTHM0R1 DMJTYO4 MN Steryl-sulfatase (STS) DMJTYO4 MT DTT DMJTYO4 MA Inhibitor DMJTYO4 RN Synergistic effects of E2MATE and norethindrone acetate on steroid sulfatase inhibition: a randomized phase I proof-of-principle clinical study in women of reproductive age. Reprod Sci. 2014 Oct;21(10):1256-65. DMJTYO4 RU https://pubmed.ncbi.nlm.nih.gov/24604234 DMKA705 DI DMKA705 DMKA705 DN PGL-2001 DMKA705 MI TTHM0R1 DMKA705 MN Steryl-sulfatase (STS) DMKA705 MT DTT DMKA705 MA Inhibitor DMKA705 RN Synergistic effects of E2MATE and norethindrone acetate on steroid sulfatase inhibition: a randomized phase I proof-of-principle clinical study in women of reproductive age. Reprod Sci. 2014 Oct;21(10):1256-65. DMKA705 RU https://pubmed.ncbi.nlm.nih.gov/24604234 DM9JGTQ DI DM9JGTQ DM9JGTQ DN PH10 nasal spray DM9JGTQ MI TT3FOGT DM9JGTQ MN Chemosensory receptor (CheR) DM9JGTQ MT DTT DM9JGTQ MA Modulator DM9JGTQ RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DM9JGTQ RU http://phrma-docs.phrma.org/files/dmfile/MID_Mental-Illness-2017-Drug-List_Final.pdf DM71HVW DI DM71HVW DM71HVW DN PH-794428 DM71HVW MI TTKMAZ6 DM71HVW MN Growth hormone receptor (GHR) DM71HVW MT DTT DM71HVW MA Modulator DM71HVW RN PEGylation of somatropin (recombinant human growth hormone): impact on its clearance in humans.Xenobiotica.2008 Oct;38(10):1340-51. DM71HVW RU https://www.ncbi.nlm.nih.gov/pubmed/18802875 DMGYBZI DI DMGYBZI DMGYBZI DN PHA-739358 DMGYBZI MI TT9RTBL DMGYBZI MN Aurora B messenger RNA (AURKB mRNA) DMGYBZI MT DTT DMGYBZI MA Inhibitor DMGYBZI RN Potent and selective Aurora inhibitors identified by the expansion of a novel scaffold for protein kinase inhibition. J Med Chem. 2005 Apr 21;48(8):3080-4. DMGYBZI RU https://pubmed.ncbi.nlm.nih.gov/15828847 DMGYBZI DI DMGYBZI DMGYBZI DN PHA-739358 DMGYBZI MI TTPS3C0 DMGYBZI MN Aurora kinase A (AURKA) DMGYBZI MT DTT DMGYBZI MA Inhibitor DMGYBZI RN Cell cycle kinases as therapeutic targets for cancer. Nat Rev Drug Discov. 2009 Jul;8(7):547-66. DMGYBZI RU https://pubmed.ncbi.nlm.nih.gov/19568282 DMGYBZI DI DMGYBZI DMGYBZI DN PHA-739358 DMGYBZI MI TT5LS6T DMGYBZI MN Aurora kinase B (AURKB) DMGYBZI MT DTT DMGYBZI MA Inhibitor DMGYBZI RN Cell cycle kinases as therapeutic targets for cancer. Nat Rev Drug Discov. 2009 Jul;8(7):547-66. DMGYBZI RU https://pubmed.ncbi.nlm.nih.gov/19568282 DMGYBZI DI DMGYBZI DMGYBZI DN PHA-739358 DMGYBZI MI TTLYXIT DMGYBZI MN Aurora kinase C (AURKC) DMGYBZI MT DTT DMGYBZI MA Inhibitor DMGYBZI RN Potent and selective Aurora inhibitors identified by the expansion of a novel scaffold for protein kinase inhibition. J Med Chem. 2005 Apr 21;48(8):3080-4. DMGYBZI RU https://pubmed.ncbi.nlm.nih.gov/15828847 DMS2Q9G DI DMS2Q9G DMS2Q9G DN PHA848125 DMS2Q9G MI TT7HF4W DMS2Q9G MN Cyclin-dependent kinase 2 (CDK2) DMS2Q9G MT DTT DMS2Q9G MA Inhibitor DMS2Q9G RN Identification of N,1,4,4-tetramethyl-8-{[4-(4-methylpiperazin-1-yl)phenyl]amino}-4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline-3-carboxamide (PHA-848125), a potent, orally available cyclin dependent kinase inhibitor. J Med Chem. 2009 Aug 27;52(16):5152-63. DMS2Q9G RU https://pubmed.ncbi.nlm.nih.gov/19603809 DMRP3CV DI DMRP3CV DMRP3CV DN Phenylalanine hydroxylase DMRP3CV MI TTGSVH2 DMRP3CV MN Phenylalanine hydroxylase (PAH) DMRP3CV MT DTT DMRP3CV MA Modulator DMRP3CV RN Single-dose, subcutaneous recombinant phenylalanine ammonia lyase conjugated with polyethylene glycol in adult patients with phenylketonuria: an open-label, multicentre, phase 1 dose-escalation trial. Lancet. 2014 Jul 5;384(9937):37-44. DMRP3CV RU https://pubmed.ncbi.nlm.nih.gov/24743000 DMBHPDW DI DMBHPDW DMBHPDW DN Phenylbutyrate DMBHPDW MI TTNJYV2 DMBHPDW MN Gamma-aminobutyric acid receptor (GAR) DMBHPDW MT DTT DMBHPDW MA Agonist DMBHPDW RN Emerging disease-modifying therapies for the treatment of motor neuron disease/amyotropic lateral sclerosis. Expert Opin Emerg Drugs. 2007 May;12(2):229-52. DMBHPDW RU https://pubmed.ncbi.nlm.nih.gov/17604499 DMBHPDW DI DMBHPDW DMBHPDW DN Phenylbutyrate DMBHPDW MI TT6R7JZ DMBHPDW MN Histone deacetylase 1 (HDAC1) DMBHPDW MT DTT DMBHPDW MA Inhibitor DMBHPDW RN Emerging disease-modifying therapies for the treatment of motor neuron disease/amyotropic lateral sclerosis. Expert Opin Emerg Drugs. 2007 May;12(2):229-52. DMBHPDW RU https://pubmed.ncbi.nlm.nih.gov/17604499 DMBHPDW DI DMBHPDW DMBHPDW DN Phenylbutyrate DMBHPDW MI TTRK8B9 DMBHPDW MN Sodium channel unspecific (NaC) DMBHPDW MT DTT DMBHPDW MA Blocker DMBHPDW RN Emerging disease-modifying therapies for the treatment of motor neuron disease/amyotropic lateral sclerosis. Expert Opin Emerg Drugs. 2007 May;12(2):229-52. DMBHPDW RU https://pubmed.ncbi.nlm.nih.gov/17604499 DMJWD62 DI DMJWD62 DMJWD62 DN phorbol 12-myristate 13-acetate DMJWD62 MI TTGJFK1 DMJWD62 MN Calcium-activated potassium channel KCa4.1 (KCNT1) DMJWD62 MT DTT DMJWD62 MA Activator DMJWD62 RN Opposite regulation of Slick and Slack K+ channels by neuromodulators. J Neurosci. 2006 May 10;26(19):5059-68. DMJWD62 RU https://pubmed.ncbi.nlm.nih.gov/16687497 DMJWD62 DI DMJWD62 DMJWD62 DN phorbol 12-myristate 13-acetate DMJWD62 MI TTLU5FO DMJWD62 MN Calcium-activated potassium channel KCa4.2 (KCNT2) DMJWD62 MT DTT DMJWD62 MA Inhibitor (gating inhibitor) DMJWD62 RN Opposite regulation of Slick and Slack K+ channels by neuromodulators. J Neurosci. 2006 May 10;26(19):5059-68. DMJWD62 RU https://pubmed.ncbi.nlm.nih.gov/16687497 DMJWD62 DI DMJWD62 DMJWD62 DN phorbol 12-myristate 13-acetate DMJWD62 MI TTEO25X DMJWD62 MN Inward rectifier potassium channel Kir3.4 (KCNJ5) DMJWD62 MT DTT DMJWD62 MA Inhibitor (gating inhibitor) DMJWD62 RN Molecular basis for the inhibition of G protein-coupled inward rectifier K(+) channels by protein kinase C. Proc Natl Acad Sci U S A. 2004 Jan 27;101(4):1087-92. DMJWD62 RU https://pubmed.ncbi.nlm.nih.gov/14732702 DMJWD62 DI DMJWD62 DMJWD62 DN phorbol 12-myristate 13-acetate DMJWD62 MI TTKP2SU DMJWD62 MN Transient receptor potential cation channel V4 (TRPV4) DMJWD62 MT DTT DMJWD62 MA Activator DMJWD62 RN Activation of TRPV4 channels (hVRL-2/mTRP12) by phorbol derivatives. J Biol Chem. 2002 Apr 19;277(16):13569-77. DMJWD62 RU https://pubmed.ncbi.nlm.nih.gov/11827975 DM4FIWC DI DM4FIWC DM4FIWC DN PI-88/Taxotere DM4FIWC MI TTJGNVC DM4FIWC MN Apoptosis regulator Bcl-2 (BCL-2) DM4FIWC MT DTT DM4FIWC MA Modulator DM4FIWC RN Multicentre phase I/II study of PI-88, a heparanase inhibitor in combination with docetaxel in patients with metastatic castrate-resistant prostate cancer. Ann Oncol. 2010 Jun;21(6):1302-7. DM4FIWC RU https://pubmed.ncbi.nlm.nih.gov/19917571 DM4FIWC DI DM4FIWC DM4FIWC DN PI-88/Taxotere DM4FIWC MI TT63KYR DM4FIWC MN Tubulin beta-1 chain (TUBB1) DM4FIWC MT DTT DM4FIWC MA Modulator DM4FIWC RN Multicentre phase I/II study of PI-88, a heparanase inhibitor in combination with docetaxel in patients with metastatic castrate-resistant prostate cancer. Ann Oncol. 2010 Jun;21(6):1302-7. DM4FIWC RU https://pubmed.ncbi.nlm.nih.gov/19917571 DM3ZEYL DI DM3ZEYL DM3ZEYL DN Piboserod DM3ZEYL MI TT07C3Y DM3ZEYL MN 5-HT 4 receptor (HTR4) DM3ZEYL MT DTT DM3ZEYL MA Antagonist DM3ZEYL RN Irritable bowel syndrome: new agents targeting serotonin receptor subtypes. Drugs. 2001;61(3):317-32. DM3ZEYL RU https://pubmed.ncbi.nlm.nih.gov/11293643 DMYL7VR DI DMYL7VR DMYL7VR DN Piclamilast DMYL7VR MI TTZ97H5 DMYL7VR MN Phosphodiesterase 4A (PDE4A) DMYL7VR MT DTT DMYL7VR MA Inhibitor DMYL7VR RN Effects of piclamilast, a selective phosphodiesterase-4 inhibitor, on oxidative burst of sputum cells from mild asthmatics and stable COPD patients. Lung. 2004;182(6):369-77. DMYL7VR RU https://pubmed.ncbi.nlm.nih.gov/15765929 DMYL7VR DI DMYL7VR DMYL7VR DN Piclamilast DMYL7VR MI TTVIAT9 DMYL7VR MN Phosphodiesterase 4B (PDE4B) DMYL7VR MT DTT DMYL7VR MA Inhibitor DMYL7VR RN Effects of piclamilast, a selective phosphodiesterase-4 inhibitor, on oxidative burst of sputum cells from mild asthmatics and stable COPD patients. Lung. 2004;182(6):369-77. DMYL7VR RU https://pubmed.ncbi.nlm.nih.gov/15765929 DMYL7VR DI DMYL7VR DMYL7VR DN Piclamilast DMYL7VR MI TTSKMI8 DMYL7VR MN Phosphodiesterase 4D (PDE4D) DMYL7VR MT DTT DMYL7VR MA Inhibitor DMYL7VR RN Effects of piclamilast, a selective phosphodiesterase-4 inhibitor, on oxidative burst of sputum cells from mild asthmatics and stable COPD patients. Lung. 2004;182(6):369-77. DMYL7VR RU https://pubmed.ncbi.nlm.nih.gov/15765929 DMMO46E DI DMMO46E DMMO46E DN Pidilizumab DMMO46E MI TT8ZLTI DMMO46E MN Programmed cell death 1 ligand 1 (PD-L1) DMMO46E MT DTT DMMO46E RN PD-1 blockade by CT-011, anti-PD-1 antibody, enhances ex vivo T-cell responses to autologous dendritic cell/myeloma fusion vaccine. J Immunother. 2011 Jun;34(5):409-18. DMMO46E RU https://pubmed.ncbi.nlm.nih.gov/21577144 DMAFZ84 DI DMAFZ84 DMAFZ84 DN PIKAMILONE DMAFZ84 MI TTNJYV2 DMAFZ84 MN Gamma-aminobutyric acid receptor (GAR) DMAFZ84 MT DTT DMAFZ84 MA Modulator DMAFZ84 RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015 DMAFZ84 RU https://www.accessdata.fda.gov/scripts/cder/drugsatfda/ DM96VWD DI DM96VWD DM96VWD DN PINOCEMBRIN DM96VWD MI TTI84H7 DM96VWD MN Cytochrome P450 1B1 (CYP1B1) DM96VWD MT DTT DM96VWD MA Inhibitor DM96VWD RN Selective inhibition of methoxyflavonoids on human CYP1B1 activity. Bioorg Med Chem. 2010 Sep 1;18(17):6310-5. DM96VWD RU https://pubmed.ncbi.nlm.nih.gov/20696580 DM276N1 DI DM276N1 DM276N1 DN Piritrexim DM276N1 MI DTI7UX6 DM276N1 MN Breast cancer resistance protein (ABCG2) DM276N1 MT DTP DM276N1 MA Substrate DM276N1 RN Mutant Gly482 and Thr482 ABCG2 mediate high-level resistance to lipophilic antifolates. Cancer Chemother Pharmacol. 2006 Dec;58(6):826-34. DM276N1 RU https://doi.org/10.1007/s00280-006-0230-9 DM276N1 DI DM276N1 DM276N1 DN Piritrexim DM276N1 MI TTYZVDJ DM276N1 MN Dihydrofolate reductase (DHFR) DM276N1 MT DTT DM276N1 MA Modulator DM276N1 RN Structural variations of piritrexim, a lipophilic inhibitor of human dihydrofolate reductase: synthesis, antitumor activity and molecular modeling ... Eur J Med Chem. 2004 Dec;39(12):1079-88. DM276N1 RU https://www.ncbi.nlm.nih.gov/pubmed/15571870 DMC3T2S DI DMC3T2S DMC3T2S DN PIRODOMAST DMC3T2S MI TTTWGIX DMC3T2S MN Leukotriene receptor (LTR) DMC3T2S MT DTT DMC3T2S MA Modulator DMC3T2S RN Antiallergy activity of Sch 37224, a new inhibitor of leukotriene formation. J Pharmacol Exp Ther. 1988 Dec;247(3):997-1003. DMC3T2S RU https://pubmed.ncbi.nlm.nih.gov/2462630 DMHI6GE DI DMHI6GE DMHI6GE DN Pirsidomine DMHI6GE MI TT6HPVC DMHI6GE MN Guanylate cyclase (GC) DMHI6GE MT DTT DMHI6GE MA Modulator DMHI6GE RN Activation of soluble guanylyl cyclase by the nitrovasodilator 3-morpholinosydnonimine involves formation of S-nitrosoglutathione. Mol Pharmacol. 1998 Jul;54(1):207-12. DMHI6GE RU https://pubmed.ncbi.nlm.nih.gov/9658207 DMKEV7N DI DMKEV7N DMKEV7N DN PK1 DMKEV7N MI TTCGY2K DMKEV7N MN DNA topoisomerase II alpha (TOP2A) DMKEV7N MT DTT DMKEV7N MA Modulator DMKEV7N RN Phase II studies of polymer-doxorubicin (PK1, FCE28068) in the treatment of breast, lung and colorectal cancer. Int J Oncol. 2009 Jun;34(6):1629-36. DMKEV7N RU https://pubmed.ncbi.nlm.nih.gov/19424581 DMHUCQS DI DMHUCQS DMHUCQS DN PL-3994 DMHUCQS MI TTJME02 DMHUCQS MN Atrial natriuretic peptide receptor A (NPR1) DMHUCQS MT DTT DMHUCQS MA Agonist DMHUCQS RN In vitro and in vivo pharmacological profile of PL-3994, a novel cyclic peptide (Hept-cyclo(Cys-His-Phe-d-Ala-Gly-Arg-d-Nle-Asp-Arg-Ile-Ser-Cys)-Tyr-[Arg mimetic]-NH2) natriuretic peptide receptor-A agonist that is resistant to neutral endopeptidase and acts as a bronchodilator. Pulm Pharmacol Ther. 2013 April; 26(2): 229-238. DMHUCQS RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4070431/ DMYUO6B DI DMYUO6B DMYUO6B DN PlaMavax DMYUO6B MI TTDUK07 DMYUO6B MN Plasmodium Thrombospondin relate anonymous protein (Plasm TRAP) DMYUO6B MT DTT DMYUO6B RN Lipid kinase enters the malaria stage. SciBX 6(48); doi:10.1038/scibx.2013.1373. Dec. 19 2013 DMYUO6B RU http://www.nature.com/scibx/journal/v6/n48/full/scibx.2013.1373.html DMOB1EM DI DMOB1EM DMOB1EM DN Plasmin DMOB1EM MI TTWODQF DMOB1EM MN Fibrin (FG) DMOB1EM MT DTT DMOB1EM MA Modulator DMOB1EM RN ClinicalTrials.gov (NCT01014975) A Safety and Dose Finding Study of Plasmin (Human) Administered Into the Middle Cerebral Artery of Stroke Patients. U.S. National Institutes of Health. DMOB1EM RU https://clinicaltrials.gov/ct2/show/NCT01014975 DMK10ZC DI DMK10ZC DMK10ZC DN PLECONARIL DMK10ZC MI TT87Q2D DMK10ZC MN Picornavirus Capsid protein VP1 (PicVir VP1) DMK10ZC MT DTT DMK10ZC MA Modulator DMK10ZC RN Relationship of pleconaril susceptibility and clinical outcomes in treatment of common colds caused by rhinoviruses. Antimicrob Agents Chemother. 2005 Nov;49(11):4492-9. DMK10ZC RU https://pubmed.ncbi.nlm.nih.gov/16251287 DM7Y60I DI DM7Y60I DM7Y60I DN Plevitrexed DM7Y60I MI TTU6BFZ DM7Y60I MN Candida Thymidylate synthase (Candi TMP1) DM7Y60I MT DTT DM7Y60I MA Inhibitor DM7Y60I RN Cooperative inhibition of human thymidylate synthase by mixtures of active site binding and allosteric inhibitors. Biochemistry. 2007 Mar 13;46(10):2823-30. DM7Y60I RU https://pubmed.ncbi.nlm.nih.gov/17297914 DMTL39C DI DMTL39C DMTL39C DN Plevitrexed (R)-isomer DMTL39C MI TTU6BFZ DMTL39C MN Candida Thymidylate synthase (Candi TMP1) DMTL39C MT DTT DMTL39C MA Inhibitor DMTL39C RN Cooperative inhibition of human thymidylate synthase by mixtures of active site binding and allosteric inhibitors. Biochemistry. 2007 Mar 13;46(10):2823-30. DMTL39C RU https://pubmed.ncbi.nlm.nih.gov/17297914 DMTL39C DI DMTL39C DMTL39C DN Plevitrexed (R)-isomer DMTL39C MI TT5FOMZ DMTL39C MN Thymidylate synthase (TYMS) DMTL39C MT DTT DMTL39C MA Inhibitor DMTL39C RN Differential effect of 1,10-phenanthroline on mammalian, yeast, and parasite glycosylphosphatidylinositol anchor synthesis. Biochem Biophys Res Commun. 2001 Nov 16;288(5):1112-8. DMTL39C RU https://pubmed.ncbi.nlm.nih.gov/11700026 DMRTD7I DI DMRTD7I DMRTD7I DN PLX8394 DMRTD7I MI TTWCGQT DMRTD7I MN Serine/threonine-protein kinase B-raf (BRAF) DMRTD7I MT DTT DMRTD7I MA Inhibitor DMRTD7I RN Identification of PLX4032-resistance mechanisms and implications for novel RAF inhibitors. Pigment Cell Melanoma Res. 2014 Mar;27(2):253-62. DMRTD7I RU https://pubmed.ncbi.nlm.nih.gov/24283590 DMMKOPX DI DMMKOPX DMMKOPX DN PM-00104 DMMKOPX MI TTUTN1I DMMKOPX MN Human Deoxyribonucleic acid (hDNA) DMMKOPX MT DTT DMMKOPX MA Modulator DMMKOPX RN Zalypsis has in vitro activity in acute myeloid blasts and leukemic progenitor cells through the induction of a DNA damage response. Haematologica. 2011 May;96(5):687-95. DMMKOPX RU https://pubmed.ncbi.nlm.nih.gov/21330323 DMS34YO DI DMS34YO DMS34YO DN PM184 DMS34YO MI TTHVQ4N DMS34YO MN Tubulin polymerization (TubP) DMS34YO MT DTT DMS34YO MA Inhibitor DMS34YO RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMS34YO RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DM0OVZ2 DI DM0OVZ2 DM0OVZ2 DN PMID27841036-Compound-37 DM0OVZ2 MI TTVDSZ0 DM0OVZ2 MN Poly [ADP-ribose] polymerase 1 (PARP1) DM0OVZ2 MT DTT DM0OVZ2 MA Inhibitor DM0OVZ2 RN PARP inhibitors as antitumor agents: a patent update (2013-2015).Expert Opin Ther Pat. 2017 Mar;27(3):363-382. DM0OVZ2 RU https://www.ncbi.nlm.nih.gov/pubmed/27841036 DM0OVZ2 DI DM0OVZ2 DM0OVZ2 DN PMID27841036-Compound-37 DM0OVZ2 MI TTQ4V96 DM0OVZ2 MN Poly [ADP-ribose] polymerase 2 (PARP2) DM0OVZ2 MT DTT DM0OVZ2 MA Inhibitor DM0OVZ2 RN PARP inhibitors as antitumor agents: a patent update (2013-2015).Expert Opin Ther Pat. 2017 Mar;27(3):363-382. DM0OVZ2 RU https://www.ncbi.nlm.nih.gov/pubmed/27841036 DM0OVZ2 DI DM0OVZ2 DM0OVZ2 DN PMID27841036-Compound-37 DM0OVZ2 MI TTVUSO7 DM0OVZ2 MN Tankyrase-1 (TNKS-1) DM0OVZ2 MT DTT DM0OVZ2 MA Inhibitor DM0OVZ2 RN PARP inhibitors as antitumor agents: a patent update (2013-2015).Expert Opin Ther Pat. 2017 Mar;27(3):363-382. DM0OVZ2 RU https://www.ncbi.nlm.nih.gov/pubmed/27841036 DM0OVZ2 DI DM0OVZ2 DM0OVZ2 DN PMID27841036-Compound-37 DM0OVZ2 MI TTFQI4H DM0OVZ2 MN Tankyrase-2 (TNKS-2) DM0OVZ2 MT DTT DM0OVZ2 MA Inhibitor DM0OVZ2 RN PARP inhibitors as antitumor agents: a patent update (2013-2015).Expert Opin Ther Pat. 2017 Mar;27(3):363-382. DM0OVZ2 RU https://www.ncbi.nlm.nih.gov/pubmed/27841036 DMZUAJ4 DI DMZUAJ4 DMZUAJ4 DN PMX-53 DMZUAJ4 MI TTXV4FI DMZUAJ4 MN Albendazole monooxygenase (CYP3A4) DMZUAJ4 MT DTT DMZUAJ4 MA Inhibitor DMZUAJ4 RN Peptidomimetic C5a receptor antagonists with hydrophobic substitutions at the C-terminus: increased receptor specificity and in vivo activity. Bioorg Med Chem Lett. 2006 Oct 1;16(19):5088-92. DMZUAJ4 RU https://pubmed.ncbi.nlm.nih.gov/16876401 DMZUAJ4 DI DMZUAJ4 DMZUAJ4 DN PMX-53 DMZUAJ4 MI TTHXFA1 DMZUAJ4 MN C5a anaphylatoxin chemotactic receptor (C5AR1) DMZUAJ4 MT DTT DMZUAJ4 MA Modulator DMZUAJ4 RN Company report (Arana Therapeutics) DMZUAJ4 RU http://www.asx.com.au/asxpdf/20090219/pdf/31g4hr7254nxxr.pdf DMZUAJ4 DI DMZUAJ4 DMZUAJ4 DN PMX-53 DMZUAJ4 MI TTD0CIQ DMZUAJ4 MN Melanocortin receptor 4 (MC4R) DMZUAJ4 MT DTT DMZUAJ4 MA Inhibitor DMZUAJ4 RN Peptidomimetic C5a receptor antagonists with hydrophobic substitutions at the C-terminus: increased receptor specificity and in vivo activity. Bioorg Med Chem Lett. 2006 Oct 1;16(19):5088-92. DMZUAJ4 RU https://pubmed.ncbi.nlm.nih.gov/16876401 DMZUAJ4 DI DMZUAJ4 DMZUAJ4 DN PMX-53 DMZUAJ4 MI TTNT7K8 DMZUAJ4 MN Nociceptin receptor (OPRL1) DMZUAJ4 MT DTT DMZUAJ4 MA Inhibitor DMZUAJ4 RN Peptidomimetic C5a receptor antagonists with hydrophobic substitutions at the C-terminus: increased receptor specificity and in vivo activity. Bioorg Med Chem Lett. 2006 Oct 1;16(19):5088-92. DMZUAJ4 RU https://pubmed.ncbi.nlm.nih.gov/16876401 DMZUAJ4 DI DMZUAJ4 DMZUAJ4 DN PMX-53 DMZUAJ4 MI TTYO0A3 DMZUAJ4 MN Substance-K receptor (TACR2) DMZUAJ4 MT DTT DMZUAJ4 MA Inhibitor DMZUAJ4 RN Peptidomimetic C5a receptor antagonists with hydrophobic substitutions at the C-terminus: increased receptor specificity and in vivo activity. Bioorg Med Chem Lett. 2006 Oct 1;16(19):5088-92. DMZUAJ4 RU https://pubmed.ncbi.nlm.nih.gov/16876401 DMZUAJ4 DI DMZUAJ4 DMZUAJ4 DN PMX-53 DMZUAJ4 MI TT4TFGN DMZUAJ4 MN Vasopressin V1a receptor (V1AR) DMZUAJ4 MT DTT DMZUAJ4 MA Inhibitor DMZUAJ4 RN Peptidomimetic C5a receptor antagonists with hydrophobic substitutions at the C-terminus: increased receptor specificity and in vivo activity. Bioorg Med Chem Lett. 2006 Oct 1;16(19):5088-92. DMZUAJ4 RU https://pubmed.ncbi.nlm.nih.gov/16876401 DMWT73D DI DMWT73D DMWT73D DN PMX-60056 DMWT73D MI TT4QPUL DMWT73D MN Antithrombin-III (ATIII) DMWT73D MT DTT DMWT73D MA Antagonist DMWT73D RN Parenteral Anticoagulants: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines. Correction in: Chest. 2013 August; 144(2): 721. DMWT73D RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3278070/ DMUVON0 DI DMUVON0 DMUVON0 DN PNT-2258 DMUVON0 MI TTFOUV4 DMUVON0 MN BCL-2 messenger RNA (BCL2 mRNA) DMUVON0 MT DTT DMUVON0 RN Clinical pipeline report, company report or official report of ProNAi. DMUVON0 RU http://pronai.com/pnt2258-targeting-bcl2/ DMM8IAQ DI DMM8IAQ DMM8IAQ DN PNU-142731A DMM8IAQ MI TT26HJ8 DMM8IAQ MN Eosinophil/lymphocyte-rich accumulation (ELR accum) DMM8IAQ MT DTT DMM8IAQ MA Modulator DMM8IAQ RN Preclinical evaluation of anti-inflammatory activities of the novel pyrrolopyrimidine PNU-142731A, a potential treatment for asthma. J Pharmacol Exp Ther. 1999 Jul;290(1):188-95. DMM8IAQ RU https://pubmed.ncbi.nlm.nih.gov/10381775 DM4OT29 DI DM4OT29 DM4OT29 DN POL-6326 DM4OT29 MI TTBID49 DM4OT29 MN C-X-C chemokine receptor type 4 (CXCR4) DM4OT29 MT DTT DM4OT29 MA Antagonist DM4OT29 RN CXCR4 inhibitors: tumor vasculature and therapeutic challenges. Recent Pat Anticancer Drug Discov. 2012 Sep;7(3):251-64. DM4OT29 RU https://pubmed.ncbi.nlm.nih.gov/22376154 DMFCIKN DI DMFCIKN DMFCIKN DN Polivy DMFCIKN MI TTBN5I7 DMFCIKN MN B-cell-specific glycoprotein B29 (CD79B) DMFCIKN MT DTT DMFCIKN MA Agonist DMFCIKN RN Polatuzumab Vedotin: First Global Approval. Drugs. 2019 Sep;79(13):1467-1475. DMFCIKN RU https://pubmed.ncbi.nlm.nih.gov/31352604 DMUXEBQ DI DMUXEBQ DMUXEBQ DN Polyamine DMUXEBQ MI DT01CKS DMUXEBQ MN Lymphocyte activation antigen 4F2 (SLC3A2) DMUXEBQ MT DTP DMUXEBQ MA Substrate DMUXEBQ RN Inhibition of polyamine synthesis and uptake reduces tumor progression and prolongs survival in mouse models of neuroblastoma. DMUXEBQ RU http://www.ncbi.nlm.nih.gov/pubmed/30700572 DMXROM7 DI DMXROM7 DMXROM7 DN Polyglutamate camptothecin DMXROM7 MI TTGTQHC DMXROM7 MN DNA topoisomerase I (TOP1) DMXROM7 MT DTT DMXROM7 MA Inhibitor DMXROM7 RN Topoisomerase I inhibitors: camptothecins and beyond. Nat Rev Cancer. 2006 Oct;6(10):789-802. DMXROM7 RU https://pubmed.ncbi.nlm.nih.gov/16990856 DM2570B DI DM2570B DM2570B DN Poly-ICLC DM2570B MI TTD24Y0 DM2570B MN Toll-like receptor 3 (TLR3) DM2570B MT DTT DM2570B MA Inducer DM2570B RN Toll like receptor-3 ligand poly-ICLC promotes the efficacy of peripheral vaccinations with tumor antigen-derived peptide epitopes in murine CNS tumor models. J Transl Med. 2007 Feb 12;5:10. DM2570B RU https://pubmed.ncbi.nlm.nih.gov/17295916 DM3QDA6 DI DM3QDA6 DM3QDA6 DN Polynoma-1 DM3QDA6 MI TT362RB DM3QDA6 MN MART-1 melanoma antigen (MLANA) DM3QDA6 MT DTT DM3QDA6 RN An immuno-oncology company developing a novel polyvalent antigen therapy for the treatment of melanoma. Polynoma. 2015. DM3QDA6 RU http://www.polynoma.com/ DM3QDA6 DI DM3QDA6 DM3QDA6 DN Polynoma-1 DM3QDA6 MI TTWSKHD DM3QDA6 MN Melanoma-associated antigen 3 (MAGEA3) DM3QDA6 MT DTT DM3QDA6 RN An immuno-oncology company developing a novel polyvalent antigen therapy for the treatment of melanoma. Polynoma. 2015. DM3QDA6 RU http://www.polynoma.com/ DM3QDA6 DI DM3QDA6 DM3QDA6 DN Polynoma-1 DM3QDA6 MI TTULVH8 DM3QDA6 MN Tyrosinase (TYR) DM3QDA6 MT DTT DM3QDA6 RN An immuno-oncology company developing a novel polyvalent antigen therapy for the treatment of melanoma. Polynoma. 2015. DM3QDA6 RU http://www.polynoma.com/ DMIAZ13 DI DMIAZ13 DMIAZ13 DN Ponezumab DMIAZ13 MI TTE4KHA DMIAZ13 MN Amyloid beta A4 protein (APP) DMIAZ13 MT DTT DMIAZ13 RN Structural basis of C-terminal beta-amyloid peptide binding by the antibody ponezumab for the treatment of Alzheimer's disease. J Mol Biol. 2012 Aug 24;421(4-5):525-36. DMIAZ13 RU https://pubmed.ncbi.nlm.nih.gov/22197375 DM5HMTB DI DM5HMTB DM5HMTB DN Porphobilinogen DM5HMTB MI TTJHKYD DM5HMTB MN Delta-aminolevulinic acid dehydratase (ALAD) DM5HMTB MT DTT DM5HMTB MA Inhibitor DM5HMTB RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DM5HMTB RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMH0LM2 DI DMH0LM2 DMH0LM2 DN POT-4 DMH0LM2 MI TTJGY7A DMH0LM2 MN Complement C3 (CO3) DMH0LM2 MT DTT DMH0LM2 MA Inhibitor DMH0LM2 RN Compstatin: A Complement Inhibitor on its Way to Clinical Application. Adv Exp Med Biol. 2008; 632: 273-292. DMH0LM2 RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2700864/ DMTE8DC DI DMTE8DC DMTE8DC DN Pozelimab DMTE8DC MI TTKANGO DMTE8DC MN Complement C5 (CO5) DMTE8DC MT DTT DMTE8DC MA Inhibitor DMTE8DC RN Inhibition of complement pathway activation with Pozelimab, a fully human antibody to complement component C5. PLoS One. 2020 May 8;15(5):e0231892. DMTE8DC RU https://pubmed.ncbi.nlm.nih.gov/32384086 DM4EHVB DI DM4EHVB DM4EHVB DN PPI-668 DM4EHVB MI TTCJ2X8 DM4EHVB MN Hepatitis C virus Non-structural 5A (HCV NS5A) DM4EHVB MT DTT DM4EHVB MA Modulator DM4EHVB RN Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41. DM4EHVB RU https://www.ncbi.nlm.nih.gov/pubmed/15950434 DMM6J5Z DI DMM6J5Z DMM6J5Z DN PQ-912 DMM6J5Z MI TTJ7YTV DMM6J5Z MN Glutaminyl cyclase (QPCT) DMM6J5Z MT DTT DMM6J5Z MA Inhibitor DMM6J5Z RN Pyroglutamate-Modified Amyloid Beta Peptides: Emerging Targets for Alzheimer s Disease ImmunotherapyRoxanna Perez-Garmendia, Goar Gevorkian. Curr Neuropharmacol. 2013 September; 11(5): 491-498. DMM6J5Z RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3763757/ DMMCYZ8 DI DMMCYZ8 DMMCYZ8 DN PQR309 DMMCYZ8 MI TTTHBCA DMMCYZ8 MN PI3-kinase beta (PIK3CB) DMMCYZ8 MT DTT DMMCYZ8 MA Inhibitor DMMCYZ8 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2154). DMMCYZ8 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2154 DMMCYZ8 DI DMMCYZ8 DMMCYZ8 DN PQR309 DMMCYZ8 MI TTHBTOP DMMCYZ8 MN PI3-kinase gamma (PIK3CG) DMMCYZ8 MT DTT DMMCYZ8 MA Inhibitor DMMCYZ8 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2155). DMMCYZ8 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2155 DMMCYZ8 DI DMMCYZ8 DMMCYZ8 DN PQR309 DMMCYZ8 MI TTCJG29 DMMCYZ8 MN Serine/threonine-protein kinase mTOR (mTOR) DMMCYZ8 MT DTT DMMCYZ8 MA Inhibitor DMMCYZ8 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2109). DMMCYZ8 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2109 DM1O0DV DI DM1O0DV DM1O0DV DN Pradefovir DM1O0DV MI DE4LYSA DM1O0DV MN Cytochrome P450 3A4 (CYP3A4) DM1O0DV MT DME DM1O0DV MA Metabolism DM1O0DV RN Metabolic activation of pradefovir by CYP3A4 and its potential as an inhibitor or inducer. Antimicrob Agents Chemother. 2006 Sep;50(9):2926-31. DM1O0DV RU https://www.ncbi.nlm.nih.gov/pubmed/?term=16940083 DM1O0DV DI DM1O0DV DM1O0DV DN Pradefovir DM1O0DV MI TTS5K1M DM1O0DV MN Hepatitis B virus Reverse transcriptase (HBV RT) DM1O0DV MT DTT DM1O0DV MA Modulator DM1O0DV RN DOI: 10.1128/AAC.01566-05 DM1O0DV RU http://aac.asm.org/content/50/9/2926.full DMIVMR3 DI DMIVMR3 DMIVMR3 DN Prajmaline DMIVMR3 MI DECB0K3 DMIVMR3 MN Cytochrome P450 2D6 (CYP2D6) DMIVMR3 MT DME DMIVMR3 MA Metabolism DMIVMR3 RN Pharmacokinetics of N-propylajmaline in relation to polymorphic sparteine oxidation. Klin Wochenschr. 1985 Nov 15;63(22):1180-6. DMIVMR3 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=4079282 DM73UTG DI DM73UTG DM73UTG DN PRALNACASAN DM73UTG MI TTCQIBE DM73UTG MN Caspase-1 (CASP1) DM73UTG MT DTT DM73UTG MA Modulator DM73UTG RN Pralnacasan, an inhibitor of interleukin-1beta converting enzyme, reduces joint damage in two murine models of osteoarthritis. Osteoarthritis Cartilage. 2003 Oct;11(10):738-46. DM73UTG RU https://pubmed.ncbi.nlm.nih.gov/13129693 DMBH7XI DI DMBH7XI DMBH7XI DN Pramiconazole DMBH7XI MI TTTSOUD DMBH7XI MN Candida Cytochrome P450 51 (Candi ERG11) DMBH7XI MT DTT DMBH7XI MA Modulator DMBH7XI RN Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41. DMBH7XI RU https://www.ncbi.nlm.nih.gov/pubmed/15950434 DMZT8FS DI DMZT8FS DMZT8FS DN Preverex DMZT8FS MI TTU5CF1 DMZT8FS MN Actin polymerization (Actin poly) DMZT8FS MT DTT DMZT8FS MA Modulator DMZT8FS RN Chronic hypoxia differentially up-regulates protein kinase C-mediated ovine uterine arterial contraction via actin polymerization signaling in pregnancy. Biol Reprod. 2012 Dec 21;87(6):142. DMZT8FS RU https://pubmed.ncbi.nlm.nih.gov/23136295 DMK8PTH DI DMK8PTH DMK8PTH DN PRM-151 DMK8PTH MI TTNJ5A6 DMK8PTH MN Neuronal pentraxin-2 (NPTX2) DMK8PTH MT DTT DMK8PTH MA Modulator DMK8PTH RN PRM-151 (recombinant human serum amyloid P/pentraxin 2) for the treatment of fibrosis. Drug News Perspect. 2010 Jun;23(5):305-15. DMK8PTH RU https://pubmed.ncbi.nlm.nih.gov/20603654 DMBZ6CP DI DMBZ6CP DMBZ6CP DN PRN1008 DMBZ6CP MI TTGM6VW DMBZ6CP MN Tyrosine-protein kinase BTK (ATK) DMBZ6CP MT DTT DMBZ6CP MA Inhibitor DMBZ6CP RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMBZ6CP RU http://phrma-docs.phrma.org/files/dmfile/medicines-in-development-drug-list-autoimmune-diseases.pdf DM5ZTE4 DI DM5ZTE4 DM5ZTE4 DN PRO-001 DM5ZTE4 MI TT2EDHU DM5ZTE4 MN Insulin-degrading enzyme (IDE) DM5ZTE4 MT DTT DM5ZTE4 MA Modulator DM5ZTE4 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2371). DM5ZTE4 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2371 DMFYABR DI DMFYABR DMFYABR DN PRO-044 DMFYABR MI TTWLFXU DMFYABR MN Dystrophin messenger RNA (DMD mRNA) DMFYABR MT DTT DMFYABR RN Update on neuromuscular disorders in pediatric orthopaedics: Duchenne muscular dystrophy, myelomeningocele, and cerebral palsy. J Pediatr Orthop. 2014 Oct-Nov;34 Suppl 1:S44-8. DMFYABR RU https://pubmed.ncbi.nlm.nih.gov/25207736 DMMEL6B DI DMMEL6B DMMEL6B DN PRO22 DMMEL6B MI TTSXVID DMMEL6B MN Nuclear factor NF-kappa-B (NFKB) DMMEL6B MT DTT DMMEL6B MA Inhibitor DMMEL6B RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMMEL6B RU http://phrma-docs.phrma.org/files/dmfile/MID_Skin_Diseases_2018_9_FINAL.pdf DMF9RB4 DI DMF9RB4 DMF9RB4 DN Procysteine DMF9RB4 MI DEJ1LMB DMF9RB4 MN Pyroglutamase (OPLAH) DMF9RB4 MT DME DMF9RB4 MA Metabolism DMF9RB4 RN Increased expression of the MGMT repair protein mediated by cysteine prodrugs and chemopreventative natural products in human lymphocytes and tumor cell lines. Carcinogenesis. 2007 Feb;28(2):378-89. DMF9RB4 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=16950796 DMF9RB4 DI DMF9RB4 DMF9RB4 DN Procysteine DMF9RB4 MI TTULV0X DMF9RB4 MN Reactive oxygen species (ROS) DMF9RB4 MT DTT DMF9RB4 MA Modulator DMF9RB4 RN Protective effect of procysteine on Acinetobacter pneumonia in hyperoxic conditions. J Antimicrob Chemother. 2013 Oct;68(10):2305-10. DMF9RB4 RU https://pubmed.ncbi.nlm.nih.gov/23681269 DM4MF9V DI DM4MF9V DM4MF9V DN proglumide DM4MF9V MI TTCG0AL DM4MF9V MN Cholecystokinin receptor type A (CCKAR) DM4MF9V MT DTT DM4MF9V MA Antagonist DM4MF9V RN Pharmacological properties of lorglumide as a member of a new class of cholecystokinin antagonists. Arzneimittelforschung. 1987 Nov;37(11):1265-8. DM4MF9V RU https://pubmed.ncbi.nlm.nih.gov/3440035 DMZIQ8G DI DMZIQ8G DMZIQ8G DN Prolarix DMZIQ8G MI TTJLP0R DMZIQ8G MN Quinone reductase 2 (NQO2) DMZIQ8G MT DTT DMZIQ8G MA Inhibitor DMZIQ8G RN CenterWatch. Drugs in Clinical Trials Database. CenterWatch. 2008. DMZIQ8G RU http://www.centerwatch.com/ DME25TI DI DME25TI DME25TI DN Prosaptide TX14(A) DME25TI MI TTDB5IS DME25TI MN Receptor unspecific (Rec) DME25TI MT DTT DME25TI MA Modulator DME25TI RN Central action of prosaptide TX14(A) against gp120-induced allodynia in rats. European Journal of Pain Volume 12, Issue 1, January 2008, Pages 76-81. DME25TI RU http://www.sciencedirect.com/science/article/pii/S1090380107000584 DMM7F1E DI DMM7F1E DMM7F1E DN PRUVANSERIN DMM7F1E MI TTJQOD7 DMM7F1E MN 5-HT 2A receptor (HTR2A) DMM7F1E MT DTT DMM7F1E MA Modulator DMM7F1E RN 5-HT(2A) inverse-agonists for the treatment of insomnia. Curr Top Med Chem. 2008;8(11):969-76. DMM7F1E RU https://www.ncbi.nlm.nih.gov/pubmed/18673166 DMKTP8E DI DMKTP8E DMKTP8E DN PRX002 DMKTP8E MI TT08OSU DMKTP8E MN Synuclein alpha (SNCA) DMKTP8E MT DTT DMKTP8E MA Inhibitor DMKTP8E RN Safety and Tolerability of Multiple Ascending Doses of PRX002/RG7935, an Anti-alpha-Synuclein Monoclonal Antibody, in Patients With Parkinson Disease: A Randomized Clinical Trial. JAMA Neurol. 2018 Oct 1;75(10):1206-1214. DMKTP8E RU https://pubmed.ncbi.nlm.nih.gov/29913017 DM1JNDV DI DM1JNDV DM1JNDV DN PRX00933 DM1JNDV MI TTWJBZ5 DM1JNDV MN 5-HT 2C receptor (HTR2C) DM1JNDV MT DTT DM1JNDV MA Agonist DM1JNDV RN 2011 Pipeline of Proximagen Group plc. DM1JNDV RU http://www.proximagen.com/science/pipeline/ DMR7H2V DI DMR7H2V DMR7H2V DN PRX-08066 DMR7H2V MI TT0K1SC DMR7H2V MN 5-HT 2B receptor (HTR2B) DMR7H2V MT DTT DMR7H2V MA Antagonist DMR7H2V RN Emerging treatments for pulmonary arterial hypertension. Expert Opin Emerg Drugs. 2006 Nov;11(4):609-19. DMR7H2V RU https://pubmed.ncbi.nlm.nih.gov/17064221 DMEVXS1 DI DMEVXS1 DMEVXS1 DN PRX-3140 DMEVXS1 MI TT07C3Y DMEVXS1 MN 5-HT 4 receptor (HTR4) DMEVXS1 MT DTT DMEVXS1 MA Modulator DMEVXS1 RN Clinical pipeline report, company report or official report of Nanotherapeutics. DMEVXS1 RU http://www.nanotherapeutics.com/prx-3140/ DM7YWVT DI DM7YWVT DM7YWVT DN PRX-321 DM7YWVT MI TTDWHC3 DM7YWVT MN Interleukin 4 receptor alpha (IL4R) DM7YWVT MT DTT DM7YWVT MA Agonist DM7YWVT RN Convection-enhanced drug delivery of interleukin-4 Pseudomonas exotoxin (PRX321): increased distribution and magnetic resonance monitoring. J Pharmacol Exp Ther. 2009 Aug;330(2):520-5. DM7YWVT RU https://pubmed.ncbi.nlm.nih.gov/19478131 DMHZIFJ DI DMHZIFJ DMHZIFJ DN PS-938285 DMHZIFJ MI TT30C9G DMHZIFJ MN C-X-C chemokine receptor type 2 (CXCR2) DMHZIFJ MT DTT DMHZIFJ MA Antagonist DMHZIFJ RN CenterWatch. Drugs in Clinical Trials Database. CenterWatch. 2008. DMHZIFJ RU http://www.centerwatch.com/ DMCSN69 DI DMCSN69 DMCSN69 DN PT2385 DMCSN69 MI TTSN6QU DMCSN69 MN HIF1-alpha messenger RNA (HIF1A mRNA) DMCSN69 MT DTT DMCSN69 MA Inhibitor DMCSN69 RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMCSN69 RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DMCSN69 DI DMCSN69 DMCSN69 DN PT2385 DMCSN69 MI TTWPA54 DMCSN69 MN HIF2-alpha messenger RNA (EPAS1 mRNA) DMCSN69 MT DTT DMCSN69 MA Inhibitor DMCSN69 RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMCSN69 RU http://phrma-docs.phrma.org/files/dmfile/MID_Neurological-Disorders-Drug-List_2018.pdf DMCSN69 DI DMCSN69 DMCSN69 DN PT2385 DMCSN69 MI TTDMLNT DMCSN69 MN Hypoxia-inducible factor 2 alpha (HIF-2A) DMCSN69 MT DTT DMCSN69 MA Inhibitor DMCSN69 RN Hypoxia-inducible factor 2: a novel target in gliomas.Future Med Chem. 2018 Sep 1;10(18):2227-2236. DMCSN69 RU https://pubmed.ncbi.nlm.nih.gov/30089425 DMP9TKE DI DMP9TKE DMP9TKE DN PTC299 DMP9TKE MI TT2J34L DMP9TKE MN Arachidonate 5-lipoxygenase (5-LOX) DMP9TKE MT DTT DMP9TKE MA Inhibitor DMP9TKE RN Therapeutic intervention in a rat model of ARDS: I. Dual inhibition of arachidonic acid metabolism. Circ Shock. 1990 Nov;32(3):231-42. DMP9TKE RU https://pubmed.ncbi.nlm.nih.gov/2124522 DMP9TKE DI DMP9TKE DMP9TKE DN PTC299 DMP9TKE MI TTOHSBA DMP9TKE MN Vascular endothelial growth factor A (VEGFA) DMP9TKE MT DTT DMP9TKE MA Modulator DMP9TKE RN Phase I and pharmacokinetic trial of PTC299 in pediatric patients with refractory or recurrent central nervous system tumors: a PBTC study.J Neurooncol.2015 Jan;121(1):217-24. DMP9TKE RU https://www.ncbi.nlm.nih.gov/pubmed/25407389 DMOYS8A DI DMOYS8A DMOYS8A DN PTG-300 DMOYS8A MI TTPCG5T DMOYS8A MN Hepcidin (HAMP) DMOYS8A MT DTT DMOYS8A MA Replacement DMOYS8A RN Clinical pipeline report, company report or official report of Protagonist Therapeutics. DMOYS8A RU https://www.protagonist-inc.com/pipeline/#overview DMV17HK DI DMV17HK DMV17HK DN PTI-125 DMV17HK MI TTSTRZY DMV17HK MN Filamin A (FLNA) DMV17HK MT DTT DMV17HK MA Inhibitor DMV17HK RN Reducing amyloid-related Alzheimer's disease pathogenesis by a small molecule targeting filamin A. J Neurosci. 2012 Jul 18;32(29):9773-84. DMV17HK RU https://pubmed.ncbi.nlm.nih.gov/22815492 DM0ZIT2 DI DM0ZIT2 DM0ZIT2 DN PTX-200 DM0ZIT2 MI TTWTSCV DM0ZIT2 MN RAC-alpha serine/threonine-protein kinase (AKT1) DM0ZIT2 MT DTT DM0ZIT2 MA Inhibitor DM0ZIT2 RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DM0ZIT2 RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DMJIMXH DI DMJIMXH DMJIMXH DN Puerarin DMJIMXH MI TTWJBZ5 DMJIMXH MN 5-HT 2C receptor (HTR2C) DMJIMXH MT DTT DMJIMXH MA Modulator DMJIMXH RN NPI-031G (puerarin) reduces anxiogenic effects of alcohol withdrawal or benzodiazepine inverse or 5-HT2C agonists. Pharmacol Biochem Behav. 2003 Jun;75(3):619-25. DMJIMXH RU https://www.ncbi.nlm.nih.gov/pubmed/12895679 DMW7L0Y DI DMW7L0Y DMW7L0Y DN PUL-042 DMW7L0Y MI TTAVUMS DMW7L0Y MN HUMAN toll-like receptor 2 (TLR2) DMW7L0Y MT DTT DMW7L0Y MA Agonist DMW7L0Y RN Pulmotects lead product, PUL-042, is a clinical stage inhaled therapeutic that in preclinical studies stimulates the innate immune system in minutes to provide immediate and effective protection against all major classes of pathogens that lasts for days. DMW7L0Y RU https://pulmotect.com/product/ DMW7L0Y DI DMW7L0Y DMW7L0Y DN PUL-042 DMW7L0Y MI TTLSU52 DMW7L0Y MN HUMAN toll-like receptor 6 (TLR6) DMW7L0Y MT DTT DMW7L0Y MA Agonist DMW7L0Y RN Pulmotects lead product, PUL-042, is a clinical stage inhaled therapeutic that in preclinical studies stimulates the innate immune system in minutes to provide immediate and effective protection against all major classes of pathogens that lasts for days. DMW7L0Y RU https://pulmotect.com/product/ DMW7L0Y DI DMW7L0Y DMW7L0Y DN PUL-042 DMW7L0Y MI TT2LBCR DMW7L0Y MN HUMAN toll-like receptor 9 (TLR9) DMW7L0Y MT DTT DMW7L0Y MA Agonist DMW7L0Y RN Pulmotects lead product, PUL-042, is a clinical stage inhaled therapeutic that in preclinical studies stimulates the innate immune system in minutes to provide immediate and effective protection against all major classes of pathogens that lasts for days. DMW7L0Y RU https://pulmotect.com/product/ DMBUSNL DI DMBUSNL DMBUSNL DN Pumosetrag DMBUSNL MI TTNXLKE DMBUSNL MN 5-HT 3 receptor (5HT3R) DMBUSNL MT DTT DMBUSNL MA Modulator DMBUSNL RN Novel partial 5HT3 agonist pumosetrag reduces acid reflux events in uninvestigated GERD patients after a standard refluxogenic meal: a randomized, double-blind, placebo-controlled pharmacodynamic study.Neurogastroenterol Motil.2014 Jan;26(1):13-20. DMBUSNL RU https://www.ncbi.nlm.nih.gov/pubmed/24001105 DMVUGF7 DI DMVUGF7 DMVUGF7 DN PUR-0110 DMVUGF7 MI TT4EWFY DMVUGF7 MN TNF/IL-10 release (TNF/IL10 rele) DMVUGF7 MT DTT DMVUGF7 MA Modulator DMVUGF7 RN PCT-233, a novel modulator of pro- and anti-inflammatory cytokine production. Clin Exp Immunol. 2004 Mar;135(3):440-7. DMVUGF7 RU https://pubmed.ncbi.nlm.nih.gov/15008976 DM6DK9A DI DM6DK9A DM6DK9A DN PVX-410 DM6DK9A MI TT7ILZ1 DM6DK9A MN SLAM family member 7 SLAMF7 (CS1) DM6DK9A MT DTT DM6DK9A MA Modulator DM6DK9A RN Market watch: Upcoming catalysts in Q2 2015. Nat Rev Drug Discov. 2015 Apr;14(4):228. DM6DK9A RU https://pubmed.ncbi.nlm.nih.gov/25764988 DMLVHAJ DI DMLVHAJ DMLVHAJ DN PX-12 DMLVHAJ MI TTZJ5U9 DMLVHAJ MN Thioredoxin (TXN) DMLVHAJ MT DTT DMLVHAJ MA Inhibitor DMLVHAJ RN 2-[(1-methylpropyl)dithio]-1H-imidazole inhibits tubulin polymerization through cysteine oxidation. Mol Cancer Ther. 2008 Jan;7(1):143-51. DMLVHAJ RU https://pubmed.ncbi.nlm.nih.gov/18202017 DMYISJK DI DMYISJK DMYISJK DN PX-866 DMYISJK MI TTHBTOP DMYISJK MN PI3-kinase gamma (PIK3CG) DMYISJK MT DTT DMYISJK MA Inhibitor DMYISJK RN Targeting the phosphoinositide 3-kinase pathway in cancer. Nat Rev Drug Discov. 2009 Aug;8(8):627-44. DMYISJK RU https://pubmed.ncbi.nlm.nih.gov/19644473 DMNSRY7 DI DMNSRY7 DMNSRY7 DN PXL-770 DMNSRY7 MI TTLAFZV DMNSRY7 MN AMP-activated protein kinase (AMPK) DMNSRY7 MT DTT DMNSRY7 MA Activator DMNSRY7 RN Clinical pipeline report, company report or official report of Poxel SA. DMNSRY7 RU https://www.poxelpharma.com/en_us/product-pipeline/pxl770 DMLQK6E DI DMLQK6E DMLQK6E DN PYM-50028 DMLQK6E MI TTSMLOH DMLQK6E MN Brain-derived neurotrophic factor (BDNF) DMLQK6E MT DTT DMLQK6E MA Agonist DMLQK6E RN PYM50028, a novel, orally active, nonpeptide neurotrophic factor inducer, prevents and reverses neuronal damage induced by MPP+ in mesencephalic neurons and by MPTP in a mouse model of Parkinson's disease. FASEB J. 2008 Jul;22(7):2488-97. DMLQK6E RU https://pubmed.ncbi.nlm.nih.gov/18364399 DMSOPAU DI DMSOPAU DMSOPAU DN Pyrazoloacridine DMSOPAU MI DEJGDUW DMSOPAU MN Cytochrome P450 1A2 (CYP1A2) DMSOPAU MT DME DMSOPAU MA Metabolism DMSOPAU RN The metabolism of pyrazoloacridine (NSC 366140) by cytochromes p450 and flavin monooxygenase in human liver microsomes. Clin Cancer Res. 2004 Feb 15;10(4):1471-80. DMSOPAU RU https://www.ncbi.nlm.nih.gov/pubmed/?term=14977851 DMSOPAU DI DMSOPAU DMSOPAU DN Pyrazoloacridine DMSOPAU MI DE4LYSA DMSOPAU MN Cytochrome P450 3A4 (CYP3A4) DMSOPAU MT DME DMSOPAU MA Metabolism DMSOPAU RN The metabolism of pyrazoloacridine (NSC 366140) by cytochromes p450 and flavin monooxygenase in human liver microsomes. Clin Cancer Res. 2004 Feb 15;10(4):1471-80. DMSOPAU RU https://www.ncbi.nlm.nih.gov/pubmed/?term=14977851 DMSOPAU DI DMSOPAU DMSOPAU DN Pyrazoloacridine DMSOPAU MI TT0IHXV DMSOPAU MN DNA topoisomerase II (TOP2) DMSOPAU MT DTT DMSOPAU MA Modulator DMSOPAU RN Effect of pyrazoloacridine (NSC 366140) on DNA topoisomerases I and II. Clin Cancer Res. 1998 Mar;4(3):683-91. DMSOPAU RU https://pubmed.ncbi.nlm.nih.gov/9533538 DM1794O DI DM1794O DM1794O DN Pyrethroids DM1794O MI DEMI4VE DM1794O MN Carboxylesterase 3 (CES3) DM1794O MT DME DM1794O MA Metabolism DM1794O RN Pyrethroids: mammalian metabolism and toxicity. J Agric Food Chem. 2011 Apr 13;59(7):2786-91. DM1794O RU https://www.ncbi.nlm.nih.gov/pubmed/?term=21133409 DM1794O DI DM1794O DM1794O DN Pyrethroids DM1794O MI DEVDYN7 DM1794O MN Cytochrome P450 2E1 (CYP2E1) DM1794O MT DME DM1794O MA Metabolism DM1794O RN Pyrethroids: mammalian metabolism and toxicity. J Agric Food Chem. 2011 Apr 13;59(7):2786-91. DM1794O RU https://www.ncbi.nlm.nih.gov/pubmed/?term=21133409 DMU5H3A DI DMU5H3A DMU5H3A DN PZ-128 DMU5H3A MI TTL935N DMU5H3A MN Proteinase activated receptor 1 (F2R) DMU5H3A MT DTT DMU5H3A MA Antagonist DMU5H3A RN PAR1 (Protease-Activated Receptor 1) Pepducin Therapy Targeting Myocardial Necrosis in Coronary Artery Disease and Acute Coronary Syndrome Patients Undergoing Cardiac Catheterization: A Randomized, Placebo-Controlled, Phase 2 Study. Arterioscler Thromb Vasc Biol. 2020 Dec;40(12):2990-3003. DMU5H3A RU https://pubmed.ncbi.nlm.nih.gov/33028101 DME71WA DI DME71WA DME71WA DN Q301 DME71WA MI TT2J34L DME71WA MN Arachidonate 5-lipoxygenase (5-LOX) DME71WA MT DTT DME71WA MA Inhibitor DME71WA RN Clinical pipeline report, company report or official report of Qurient. DME71WA RU http://www.qurient.com/bbs/content.php?co_id=q301 DMIZYV1 DI DMIZYV1 DMIZYV1 DN QAV-680 DMIZYV1 MI TTQDMX5 DMIZYV1 MN Prostaglandin D2 receptor 2 (PTGDR2) DMIZYV1 MT DTT DMIZYV1 MA Antagonist DMIZYV1 RN Discovery and characterization of NVP-QAV680, a potent and selective CRTh2 receptor antagonist suitable for clinical testing in allergic diseases. Bioorg Med Chem. 2013 Nov 1;21(21):6582-91. DMIZYV1 RU https://pubmed.ncbi.nlm.nih.gov/24021582 DMXY0H2 DI DMXY0H2 DMXY0H2 DN QAX-028 DMXY0H2 MI TTOXS3C DMXY0H2 MN Muscarinic acetylcholine receptor (CHRM) DMXY0H2 MT DTT DMXY0H2 MA Antagonist DMXY0H2 RN EP patent application no. 2398798, Triazolopyridine derivatives as p38 map kinase inhibitors. DMXY0H2 RU http://www.google.com/patents/EP2398798A1?cl=en DMUWFI7 DI DMUWFI7 DMUWFI7 DN QAX-576 DMUWFI7 MI TT0GVCH DMUWFI7 MN Interleukin-13 (IL13) DMUWFI7 MT DTT DMUWFI7 MA Modulator DMUWFI7 RN Intravenous anti-IL-13 mAb QAX576 for the treatment of eosinophilic esophagitis. J Allergy Clin Immunol. 2015 Feb;135(2):500-7. DMUWFI7 RU https://pubmed.ncbi.nlm.nih.gov/25226850 DMAFUHK DI DMAFUHK DMAFUHK DN QGC-001 DMAFUHK MI TTGMFY7 DMAFUHK MN Aspartyl aminopeptidase (DNPEP) DMAFUHK MT DTT DMAFUHK MA Inhibitor DMAFUHK RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMAFUHK RU http://phrma-docs.phrma.org/files/dmfile/2018_Heart-Disease-and-Stroke_MID-Drug-List.pdf DMAFUHK DI DMAFUHK DMAFUHK DN QGC-001 DMAFUHK MI TT9PBIL DMAFUHK MN Glutamyl aminopeptidase (ENPEP) DMAFUHK MT DTT DMAFUHK MA Inhibitor DMAFUHK RN Clinical pipeline report, company report or official report of Quantum Genomics. DMAFUHK RU http://www.quantum-genomics.com/www/en/science/programme-qgc001/ DMKVIWM DI DMKVIWM DMKVIWM DN QR-333 DMKVIWM MI TTFBNVI DMKVIWM MN Aldose reductase (AKR1B1) DMKVIWM MT DTT DMKVIWM MA Inhibitor DMKVIWM RN A multicenter, double-blind, safety study of QR-333 for the treatment of symptomatic diabetic peripheral neuropathy. A preliminary report. J Diabetes Complications. 2005 Sep-Oct;19(5):247-53. DMKVIWM RU https://pubmed.ncbi.nlm.nih.gov/16112498 DMIUS5X DI DMIUS5X DMIUS5X DN R1507 DMIUS5X MI TTHRID2 DMIUS5X MN Insulin-like growth factor I receptor (IGF1R) DMIUS5X MT DTT DMIUS5X MA Inhibitor DMIUS5X RN Clinical pipeline report, company report or official report of Roche (2009). DMIUS5X RU http://www.roche.com/research_and_development/pipeline/roche_pharma_pipeline.htm DMP7J0S DI DMP7J0S DMP7J0S DN R411 DMP7J0S MI TT6S84X DMP7J0S MN Integrin alpha-4/beta-1 (ITGA4/B1) DMP7J0S MT DTT DMP7J0S MA Modulator DMP7J0S RN Integrins as therapeutic targets: lessons and opportunities. Nat Rev Drug Discov. 2010 Oct;9(10):804-20. DMP7J0S RU https://pubmed.ncbi.nlm.nih.gov/20885411 DM79YAS DI DM79YAS DM79YAS DN Racotumomab DM79YAS MI TTSFNKW DM79YAS MN Tumor antigen NGcGM3 (NGcGM3) DM79YAS MT DTT DM79YAS MA Modulator DM79YAS RN Racotumomab: an anti-idiotype vaccine related to N-glycolyl-containing gangliosides - preclinical and clinical data. Front Oncol. 2012; 2: 150. DM79YAS RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3478665/ DMOI9EL DI DMOI9EL DMOI9EL DN Radezolid DMOI9EL MI TT2VX74 DMOI9EL MN Bacterial Protein synthesis (Bact PROS) DMOI9EL MT DTT DMOI9EL MA Inhibitor DMOI9EL RN Antibiotics in the clinical pipeline in 2011. J Antibiot (Tokyo). 2011 Jun;64(6):413-25. DMOI9EL RU https://pubmed.ncbi.nlm.nih.gov/21587262 DMC56T4 DI DMC56T4 DMC56T4 DN RAF265 DMC56T4 MI TTUTJGQ DMC56T4 MN Vascular endothelial growth factor receptor 2 (KDR) DMC56T4 MT DTT DMC56T4 MA Modulator DMC56T4 RN RAF265, a dual BRAF and VEGFR2 inhibitor, prevents osteoclast formation and resorption. Therapeutic implications. Invest New Drugs. 2013 Feb;31(1):200-5. DMC56T4 RU https://pubmed.ncbi.nlm.nih.gov/22773056 DM7G4Y9 DI DM7G4Y9 DM7G4Y9 DN Ralinepag DM7G4Y9 MI TTOFYT1 DM7G4Y9 MN Prostacyclin receptor (PTGIR) DM7G4Y9 MT DTT DM7G4Y9 MA Agonist DM7G4Y9 RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DM7G4Y9 RU http://phrma-docs.phrma.org/files/dmfile/2018_Heart-Disease-and-Stroke_MID-Drug-List.pdf DMBFZSX DI DMBFZSX DMBFZSX DN RALURIDINE DMBFZSX MI TT84ETX DMBFZSX MN Human immunodeficiency virus Reverse transcriptase (HIV RT) DMBFZSX MT DTT DMBFZSX MA Inhibitor DMBFZSX RN 5-Chloro-2',3'-dideoxy-3'-fluorouridine (935U83), a selective anti-human immunodeficiency virus agent with an improved metabolic and toxicological profile. Antimicrob Agents Chemother. 1994 Jul;38(7):1590-603. DMBFZSX RU https://pubmed.ncbi.nlm.nih.gov/7526782 DMP2DNS DI DMP2DNS DMP2DNS DN Rambazole DMP2DNS MI TTD7Q0R DMP2DNS MN Cytochrome P450 26 (CYP26A1) DMP2DNS MT DTT DMP2DNS MA Inhibitor DMP2DNS RN Emerging drugs for psoriasis. Expert Opin Emerg Drugs. 2009 Mar;14(1):145-63. DMP2DNS RU https://pubmed.ncbi.nlm.nih.gov/19249988 DMP2DNS DI DMP2DNS DMP2DNS DN Rambazole DMP2DNS MI TTYO0A3 DMP2DNS MN Substance-K receptor (TACR2) DMP2DNS MT DTT DMP2DNS MA Antagonist DMP2DNS RN Pharmacology of an original and selective nonpeptide antagonist ligand for the human tachykinin NK2 receptor. Eur J Pharmacol. 2005 Jun 1;516(2):104-11. DMP2DNS RU https://pubmed.ncbi.nlm.nih.gov/15925360 DMO2TYL DI DMO2TYL DMO2TYL DN Ramipril DMO2TYL MI TTGFNPD DMO2TYL MN HUMAN angiotensin-converting enzyme (ACE) DMO2TYL MT DTT DMO2TYL MA Inhibitor DMO2TYL RN Outcomes in Patients with COVID-19 Infection Taking ACEI/ARB. Curr Cardiol Rep. 2020 Apr 14;22(5):31. DMO2TYL RU https://pubmed.ncbi.nlm.nih.gov/32291526 DMM15RI DI DMM15RI DMM15RI DN Ranpirnase DMM15RI MI TTRBUYN DMM15RI MN Ribonuclease (RNase) DMM15RI MT DTT DMM15RI MA Modulator DMM15RI RN Ranpirnase (Onconase), a cytotoxic amphibian ribonuclease, manipulates tumour physiological parameters as a selective killer and a potential enhancer for chemotherapy and radiation in cancer therapy.Expert Opin Biol Ther. 2008 Jun;8(6):813-27. DMM15RI RU https://pubmed.ncbi.nlm.nih.gov/18476793 DMK2E0N DI DMK2E0N DMK2E0N DN RAXOFELAST DMK2E0N MI TTV0YFR DMK2E0N MN Lipid peroxidation (LPO) DMK2E0N MT DTT DMK2E0N MA Modulator DMK2E0N RN Lipid peroxidation inhibition by raxofelast improves angiogenesis and wound healing in experimental burn wounds. Shock. 2005 Jul;24(1):85-91. DMK2E0N RU https://pubmed.ncbi.nlm.nih.gov/15988325 DMIG98L DI DMIG98L DMIG98L DN RC-3095 DMIG98L MI TTC1MVT DMIG98L MN Gastrin-releasing peptide receptor (GRPR) DMIG98L MT DTT DMIG98L MA Inhibitor DMIG98L RN Lipid modification of GRN163, an N3'-->P5' thio-phosphoramidate oligonucleotide, enhances the potency of telomerase inhibition. Oncogene. 2005 Aug 4;24(33):5262-8. DMIG98L RU https://pubmed.ncbi.nlm.nih.gov/15940257 DM1TKG4 DI DM1TKG4 DM1TKG4 DN RDEA3170 DM1TKG4 MI TTA592U DM1TKG4 MN Urate anion exchanger 1 (URAT1) DM1TKG4 MT DTT DM1TKG4 MA Modulator DM1TKG4 RN The pathophysiology of hyperuricaemia and its possible relationship to cardiovascular disease, morbidity and mortality. BMC Nephrol. 2013; 14: 164. DM1TKG4 RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3750299/ DMNWYHD DI DMNWYHD DMNWYHD DN RDEA-684 DMNWYHD MI TTA592U DMNWYHD MN Urate anion exchanger 1 (URAT1) DMNWYHD MT DTT DMNWYHD MA Inhibitor DMNWYHD RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1031). DMNWYHD RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1031 DM4CIKA DI DM4CIKA DM4CIKA DN RDP58 DM4CIKA MI TTF8CQI DM4CIKA MN Tumor necrosis factor (TNF) DM4CIKA MT DTT DM4CIKA MA Inhibitor DM4CIKA RN RDP58, a locally active TNF inhibitor, is effective in the dextran sulphate mouse model of chronic colitis. Inflamm Res. 2002 Nov;51(11):522-31. DM4CIKA RU https://pubmed.ncbi.nlm.nih.gov/12540016 DM2CJ4O DI DM2CJ4O DM2CJ4O DN Rebmab-100 DM2CJ4O MI TTUPAD7 DM2CJ4O MN Galactoside 3(4)-L-fucosyltransferase (FUT3) DM2CJ4O MT DTT DM2CJ4O RN A phase II trial with anti-Lewis-Y monoclonal antibody (hu3S193) for the treatment of platinum resistant/refractory ovarian, fallopian tube and primary peritoneal carcinoma. Gynecol Oncol. 2015 Aug;138(2):272-7. DM2CJ4O RU https://pubmed.ncbi.nlm.nih.gov/26026738 DML8N3Y DI DML8N3Y DML8N3Y DN Recifercept DML8N3Y MI TTST7KB DML8N3Y MN Fibroblast growth factor receptor 3 (FGFR3) DML8N3Y MT DTT DML8N3Y RN In vitro and in vivo characterization of Recifercept, a soluble fibroblast growth factor receptor 3, as treatment for achondroplasia. PLoS One. 2020 Dec 28;15(12):e0244368. DML8N3Y RU https://pubmed.ncbi.nlm.nih.gov/33370388 DMCSR8I DI DMCSR8I DMCSR8I DN Recoflavone DMCSR8I MI TTSXVID DMCSR8I MN Nuclear factor NF-kappa-B (NFKB) DMCSR8I MT DTT DMCSR8I MA Modulator DMCSR8I RN DA-6034, a derivative of flavonoid, prevents and ameliorates dextran sulfate sodium-induced colitis and inhibits colon carcinogenesis. Exp Biol Med (Maywood). 2008 Feb;233(2):180-91. DMCSR8I RU https://pubmed.ncbi.nlm.nih.gov/18222973 DMURX4B DI DMURX4B DMURX4B DN Recombinant batroxobin DMURX4B MI TTWODQF DMURX4B MN Fibrin (FG) DMURX4B MT DTT DMURX4B MA Modulator DMURX4B RN Functional characterization of recombinant batroxobin, a snake venom thrombin-like enzyme, expressed from Pichia pastoris. FEBS Lett. 2004 Jul 30;571(1-3):67-73. DMURX4B RU https://pubmed.ncbi.nlm.nih.gov/15280019 DMV0A28 DI DMV0A28 DMV0A28 DN Recombinant RGD-hirudin DMV0A28 MI TT6L509 DMV0A28 MN Coagulation factor IIa (F2) DMV0A28 MT DTT DMV0A28 MA Modulator DMV0A28 RN The NMR solution structure of recombinant RGD-hirudin. Biochem Biophys Res Commun. 2007 Aug 17;360(1):103-8. DMV0A28 RU https://pubmed.ncbi.nlm.nih.gov/17585879 DMSJ3Z5 DI DMSJ3Z5 DMSJ3Z5 DN REGN1979 DMSJ3Z5 MI TTUE541 DMSJ3Z5 MN Leukocyte surface antigen Leu-16 (CD20) DMSJ3Z5 MT DTT DMSJ3Z5 MA Inhibitor DMSJ3Z5 RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMSJ3Z5 RU http://phrma-docs.phrma.org/files/dmfile/MID_Immuno-Oncology-2017_Drug-List1.pdf DMTBRPO DI DMTBRPO DMTBRPO DN REGN910-3 DMTBRPO MI TTKLQTJ DMTBRPO MN Angiopoietin-2 (ANGPT2) DMTBRPO MT DTT DMTBRPO MA Inhibitor DMTBRPO RN ClinicalTrials.gov (NCT02713204) Anti-angiOpoeitin 2 Plus Anti-vascular eNdothelial Growth Factor as a therapY for Neovascular Age Related Macular Degeneration: Evaluation of a fiXed Combination Intravitreal Injection (ONYX). U.S. National Institutes of Health. DMTBRPO RU https://clinicaltrials.gov/ct2/show/NCT02713204 DM0KBML DI DM0KBML DM0KBML DN REGN-COV2 DM0KBML MI TTZ3COY DM0KBML MN COVID-19 spike glycoprotein (S) DM0KBML MT DTT DM0KBML MA Inhibitor DM0KBML RN REGN-COV2, a Neutralizing Antibody Cocktail, in Outpatients with Covid-19. N Engl J Med. 2021 Jan 21;384(3):238-251. DM0KBML RU https://pubmed.ncbi.nlm.nih.gov/33332778 DM13OVF DI DM13OVF DM13OVF DN REMD 477 DM13OVF MI TT9O6WS DM13OVF MN Glucagon receptor (GCGR) DM13OVF MT DTT DM13OVF MA Antagonist DM13OVF RN Effect of a glucagon receptor antibody (REMD-477) in type 1 diabetes: A randomized controlled trial. Diabetes Obes Metab. 2018 May;20(5):1302-1305. DM13OVF RU https://pubmed.ncbi.nlm.nih.gov/29283470 DMJIB89 DI DMJIB89 DMJIB89 DN Remetinostat DMJIB89 MI TTBH0VX DMJIB89 MN Histone deacetylase (HDAC) DMJIB89 MT DTT DMJIB89 MA Inhibitor DMJIB89 RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMJIB89 RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DM2USXP DI DM2USXP DM2USXP DN Remlarsen DM2USXP MI TTO60BY DM2USXP MN microRNA hsa-miR-29b (MIR29b) DM2USXP MT DTT DM2USXP MA Replacement DM2USXP RN A MicroRNA-29 Mimic (Remlarsen) Represses Extracellular Matrix Expression and Fibroplasia in the Skin. J Invest Dermatol. 2019 May;139(5):1073-1081. DM2USXP RU https://pubmed.ncbi.nlm.nih.gov/30472058 DMZFV3E DI DMZFV3E DMZFV3E DN Remogli ozin-etabonate DMZFV3E MI TTN7Y4P DMZFV3E MN Sodium/glucose cotransporter 2 (SLC5A4) DMZFV3E MT DTT DMZFV3E MA Modulator DMZFV3E RN Safety, pharmacokinetics and pharmacodynamics of remogliflozin etabonate, a novel SGLT2 inhibitor, and metformin when co-administered in subjects with type 2 diabetes mellitus. BMC Pharmacol Toxicol.2013 Apr 30;14:25. DMZFV3E RU https://pubmed.ncbi.nlm.nih.gov/23631443 DMW4YK1 DI DMW4YK1 DMW4YK1 DN Remogliflozin etabonate DMW4YK1 MI TTLWPVF DMW4YK1 MN Sodium/glucose cotransporter 2 (SGLT2) DMW4YK1 MT DTT DMW4YK1 MA Inhibitor DMW4YK1 RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMW4YK1 RU http://phrma-docs.phrma.org/files/dmfile/mid-diabetes-drug-list.pdf DMW4YK1 DI DMW4YK1 DMW4YK1 DN Remogliflozin etabonate DMW4YK1 MI TTN7Y4P DMW4YK1 MN Sodium/glucose cotransporter 2 (SLC5A4) DMW4YK1 MT DTT DMW4YK1 MA Blocker DMW4YK1 RN Clinical pipeline report, company report or official report of GlaxoSmithKline (2009). DMW4YK1 RU http://www.gsk.com/investors/product_pipeline/docs/gsk-pipeline-feb09.pdf DMTGU6K DI DMTGU6K DMTGU6K DN REN-1654 DMTGU6K MI TTX1JEN DMTGU6K MN JNK signaling pathway (JNK pathway) DMTGU6K MT DTT DMTGU6K MA Modulator DMTGU6K RN US patent application no. 2006,0270,742, Compositions and methods for the treatment of neurodegenerative diseases. DMTGU6K RU http://www.google.com/patents/US20060270742 DMTGU6K DI DMTGU6K DMTGU6K DN REN-1654 DMTGU6K MI TT7KPH1 DMTGU6K MN MAPK/ERK signaling pathway (MAPK pathway) DMTGU6K MT DTT DMTGU6K MA Modulator DMTGU6K RN US patent application no. 2006,0270,742, Compositions and methods for the treatment of neurodegenerative diseases. DMTGU6K RU http://www.google.com/patents/US20060270742 DMQ73AY DI DMQ73AY DMQ73AY DN Reovirus DMQ73AY MI TTW2R9X DMQ73AY MN GTPase NRas (NRAS) DMQ73AY MT DTT DMQ73AY MA Modulator DMQ73AY RN Reovirus (Reolysin) as a potential therapy for malignant peripheral nerve sheath tumors. DMQ73AY RU http://cancerres.aacrjournals.org/content/72/8_Supplement/2488.short DMT5QSD DI DMT5QSD DMT5QSD DN Resimmune DMT5QSD MI TTZAT79 DMT5QSD MN T-cell surface glycoprotein CD3 epsilon (CD3E) DMT5QSD MT DTT DMT5QSD MA Modulator DMT5QSD RN Resimmune, an anti-CD3 recombinant immunotoxin, induces durable remissions in patients with cutaneous T-cell lymphoma.Haematologica.2015 Jun;100(6):794-800. DMT5QSD RU https://www.ncbi.nlm.nih.gov/pubmed/25795722 DMP62L5 DI DMP62L5 DMP62L5 DN Resiniferatoxin DMP62L5 MI TTMI6F5 DMP62L5 MN Transient receptor potential cation channel V1 (TRPV1) DMP62L5 MT DTT DMP62L5 MA Activator DMP62L5 RN Emerging drugs in neuropathic pain. Expert Opin Emerg Drugs. 2007 Mar;12(1):113-26. DMP62L5 RU https://pubmed.ncbi.nlm.nih.gov/17355217 DML6XSP DI DML6XSP DML6XSP DN Resiquimod DML6XSP MI TTRJ1K4 DML6XSP MN Toll-like receptor 7 (TLR7) DML6XSP MT DTT DML6XSP MA Modulator DML6XSP RN TLR agonists as vaccine adjuvants: comparison of CpG ODN and Resiquimod (R-848).Vaccine.2005 Nov 1;23(45):5263-70. DML6XSP RU https://www.ncbi.nlm.nih.gov/pubmed/16081189 DML6XSP DI DML6XSP DML6XSP DN Resiquimod DML6XSP MI TT8CWFK DML6XSP MN Toll-like receptor 8 (TLR8) DML6XSP MT DTT DML6XSP MA Modulator DML6XSP RN TLR agonists as vaccine adjuvants: comparison of CpG ODN and Resiquimod (R-848).Vaccine.2005 Nov 1;23(45):5263-70. DML6XSP RU https://www.ncbi.nlm.nih.gov/pubmed/16081189 DMNE1FR DI DMNE1FR DMNE1FR DN Resminostat DMNE1FR MI TT6R7JZ DMNE1FR MN Histone deacetylase 1 (HDAC1) DMNE1FR MT DTT DMNE1FR MA Inhibitor DMNE1FR RN 2011 Pipeline of 4SC AG. DMNE1FR RU http://www.pharmaceutical-market-research.com/publications/pharmaceutical_companies/4sc_ag_product_pipeline_review.html DMM4EJI DI DMM4EJI DMM4EJI DN Resten-NG DMM4EJI MI TTNQ5ZP DMM4EJI MN Myc messenger RNA (MYC mRNA) DMM4EJI MT DTT DMM4EJI RN Local delivery of c-myc neutrally charged antisense oligonucleotides with transport catheter inhibits myointimal hyperplasia and positively affects vascular remodeling in the rabbit balloon injury model. Catheter Cardiovasc Interv. 2001 Oct;54(2):247-56. DMM4EJI RU https://pubmed.ncbi.nlm.nih.gov/11590694 DMVXZJ4 DI DMVXZJ4 DMVXZJ4 DN RetinoStat DMVXZJ4 MI TT63DI9 DMVXZJ4 MN Endostatin (COL18A1) DMVXZJ4 MT DTT DMVXZJ4 MA Modulator DMVXZJ4 RN Safety and biodistribution of an equine infectious anemia virus-based gene therapy, RetinoStat( ), for age-related macular degeneration. Hum Gene Ther. 2012 Sep;23(9):980-91. DMVXZJ4 RU https://pubmed.ncbi.nlm.nih.gov/22716662 DMVXZJ4 DI DMVXZJ4 DMVXZJ4 DN RetinoStat DMVXZJ4 MI TTP86E2 DMVXZJ4 MN Plasminogen (PLG) DMVXZJ4 MT DTT DMVXZJ4 MA Modulator DMVXZJ4 RN Safety and biodistribution of an equine infectious anemia virus-based gene therapy, RetinoStat( ), for age-related macular degeneration. Hum Gene Ther. 2012 Sep;23(9):980-91. DMVXZJ4 RU https://pubmed.ncbi.nlm.nih.gov/22716662 DMJ37UX DI DMJ37UX DMJ37UX DN Revacept DMJ37UX MI TTTJUVZ DMJ37UX MN Platelet glycoprotein VI (GP6) DMJ37UX MT DTT DMJ37UX MA Inhibitor DMJ37UX RN Novel antiplatelet drug revacept (Dimeric Glycoprotein VI-Fc) specifically and efficiently inhibited collagen-induced platelet aggregation without affecting general hemostasis in humans. Circulation.2011 May 3;123(17):1891-9. DMJ37UX RU https://pubmed.ncbi.nlm.nih.gov/21502572 DM1FS2W DI DM1FS2W DM1FS2W DN Revamilast DM1FS2W MI TTZ97H5 DM1FS2W MN Phosphodiesterase 4A (PDE4A) DM1FS2W MT DTT DM1FS2W MA Inhibitor DM1FS2W RN WO patent application no. 2012,1109,46, Pharmaceutical composition comprising the pde4 enzyme inhibitor revamilast and a disease modifying agent, preferably methotrexate . DM1FS2W RU http://worldwide.espacenet.com/publicationDetails/biblio?DB=worldwide.espacenet.com&II=0&ND=3&adjacent=true&locale=en_EP&FT=D&date=20120823&CC=WO&NR=2012110946A1&KC=A1 DM1FS2W DI DM1FS2W DM1FS2W DN Revamilast DM1FS2W MI TTVIAT9 DM1FS2W MN Phosphodiesterase 4B (PDE4B) DM1FS2W MT DTT DM1FS2W MA Inhibitor DM1FS2W RN WO patent application no. 2012,1109,46, Pharmaceutical composition comprising the pde4 enzyme inhibitor revamilast and a disease modifying agent, preferably methotrexate . DM1FS2W RU http://worldwide.espacenet.com/publicationDetails/biblio?DB=worldwide.espacenet.com&II=0&ND=3&adjacent=true&locale=en_EP&FT=D&date=20120823&CC=WO&NR=2012110946A1&KC=A1 DM1FS2W DI DM1FS2W DM1FS2W DN Revamilast DM1FS2W MI TTSKMI8 DM1FS2W MN Phosphodiesterase 4D (PDE4D) DM1FS2W MT DTT DM1FS2W MA Inhibitor DM1FS2W RN WO patent application no. 2012,1109,46, Pharmaceutical composition comprising the pde4 enzyme inhibitor revamilast and a disease modifying agent, preferably methotrexate . DM1FS2W RU http://worldwide.espacenet.com/publicationDetails/biblio?DB=worldwide.espacenet.com&II=0&ND=3&adjacent=true&locale=en_EP&FT=D&date=20120823&CC=WO&NR=2012110946A1&KC=A1 DMFIVSR DI DMFIVSR DMFIVSR DN R-flurbiprofen DMFIVSR MI TT8JRS7 DMFIVSR MN Beta-secretase (BACE) DMFIVSR MT DTT DMFIVSR MA Inhibitor DMFIVSR RN The geminal dimethyl analogue of Flurbiprofen as a novel Abeta42 inhibitor and potential Alzheimer's disease modifying agent. Bioorg Med Chem Lett. 2006 Apr 15;16(8):2219-23. DMFIVSR RU https://pubmed.ncbi.nlm.nih.gov/16455248 DMFIVSR DI DMFIVSR DMFIVSR DN R-flurbiprofen DMFIVSR MI TT9W8GU DMFIVSR MN Gamma-secretase (GS) DMFIVSR MT DTT DMFIVSR MA Inhibitor DMFIVSR RN The geminal dimethyl analogue of Flurbiprofen as a novel Abeta42 inhibitor and potential Alzheimer's disease modifying agent. Bioorg Med Chem Lett. 2006 Apr 15;16(8):2219-23. DMFIVSR RU https://pubmed.ncbi.nlm.nih.gov/16455248 DMFIVSR DI DMFIVSR DMFIVSR DN R-flurbiprofen DMFIVSR MI TTZ3S8C DMFIVSR MN Presenilin 1 (PSEN1) DMFIVSR MT DTT DMFIVSR MA Inhibitor DMFIVSR RN The geminal dimethyl analogue of Flurbiprofen as a novel Abeta42 inhibitor and potential Alzheimer's disease modifying agent. Bioorg Med Chem Lett. 2006 Apr 15;16(8):2219-23. DMFIVSR RU https://pubmed.ncbi.nlm.nih.gov/16455248 DMFIVSR DI DMFIVSR DMFIVSR DN R-flurbiprofen DMFIVSR MI TTWN3F4 DMFIVSR MN Presenilin 2 (PSEN2) DMFIVSR MT DTT DMFIVSR MA Inhibitor DMFIVSR RN The geminal dimethyl analogue of Flurbiprofen as a novel Abeta42 inhibitor and potential Alzheimer's disease modifying agent. Bioorg Med Chem Lett. 2006 Apr 15;16(8):2219-23. DMFIVSR RU https://pubmed.ncbi.nlm.nih.gov/16455248 DMQ8K93 DI DMQ8K93 DMQ8K93 DN RFT-5.dgA DMQ8K93 MI TT10Y9E DMQ8K93 MN Interleukin 2 receptor alpha (IL2RA) DMQ8K93 MT DTT DMQ8K93 MA Modulator DMQ8K93 RN Clinical evaluation of ricin A-chain immunotoxins in patients with Hodgkin's lymphoma. Ann Oncol. 2003 May;14(5):729-36. DMQ8K93 RU https://www.ncbi.nlm.nih.gov/pubmed/12702527 DM2UGT7 DI DM2UGT7 DM2UGT7 DN RG-101 DM2UGT7 MI TTP03CE DM2UGT7 MN Hepatitis C virus microRNA miR-122 (HCV MIR122) DM2UGT7 MT DTT DM2UGT7 MA Modulator DM2UGT7 RN Company report (Isis Pharmaceuticals) DM2UGT7 RU https://www.isispharm.com/pipeline/rg-101/ DMT1ZX0 DI DMT1ZX0 DMT1ZX0 DN RG1577 DMT1ZX0 MI TTGP7BY DMT1ZX0 MN Monoamine oxidase type B (MAO-B) DMT1ZX0 MT DTT DMT1ZX0 MA Modulator DMT1ZX0 RN Sembragiline Alzheimer's Disease (Phase 2). Evotech AG, Roche. DMT1ZX0 RU http://www.alzforum.org/therapeutics/sembragiline DMT4QRD DI DMT4QRD DMT4QRD DN RG-4929 DMT4QRD MI TTN7BL9 DMT4QRD MN Corticosteroid 11-beta-dehydrogenase 1 (HSD11B1) DMT4QRD MT DTT DMT4QRD MA Inhibitor DMT4QRD RN New Therapeutic Strategies for Type 2 Diabetes: Small Molecule Approaches. 2012. Chapter 5. Page(131). DMT4QRD RU https://books.google.com.hk/books?id=0rmlVGhlJ0IC&pg=PA131&lpg=PA131&dq=RG-7234++New+Therapeutic+Strategies+for+Type+2+Diabetes&source=bl&ots=toqK7w4uiI&sig=sx5iyfQWH2bTCSZmT5aUQiKfPuM&hl=zh-CN&sa=X&ved=0CB0Q6AEwAGoVChMIsZ_k6dDGyAIViLeOCh0oUQpr#v=onepage&q=RG-7234%20%20New%20Therapeutic%20Strategies%20for%20Type%202%20Diabetes&f=false DMEFD0B DI DMEFD0B DMEFD0B DN RG6100 DMEFD0B MI TTS87KH DMEFD0B MN Microtubule-associated protein tau (MAPT) DMEFD0B MT DTT DMEFD0B MA Inhibitor DMEFD0B RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMEFD0B RU http://phrma-docs.phrma.org/files/dmfile/MID_Neurological-Disorders-Drug-List_2018.pdf DMX8JYN DI DMX8JYN DMX8JYN DN RG-7090 DMX8JYN MI TTHS256 DMX8JYN MN Metabotropic glutamate receptor 5 (mGluR5) DMX8JYN MT DTT DMX8JYN MA Antagonist DMX8JYN RN The challenges of clinical trials in fragile X syndrome. Psychopharmacology (Berl) 2014; 231(6): 1237-1250. DMX8JYN RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3932172/ DM8JMNL DI DM8JMNL DM8JMNL DN RG7155 DM8JMNL MI TT731LW DM8JMNL MN Colony stimulating factor-1 receptor (CSF-1R) DM8JMNL MT DTT DM8JMNL MA Modulator DM8JMNL RN Targeting tumor-associated macrophages with anti-CSF-1R antibody reveals a strategy for cancer therapy. Cancer Cell. 2014 Jun 16;25(6):846-59. DM8JMNL RU https://pubmed.ncbi.nlm.nih.gov/24898549 DM8JMNL DI DM8JMNL DM8JMNL DN RG7155 DM8JMNL MI TT0IQER DM8JMNL MN Macrophage colony-stimulating factor 1 (CSF1) DM8JMNL MT DTT DM8JMNL MA Antagonist DM8JMNL RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DM8JMNL RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DM8J9DC DI DM8J9DC DM8J9DC DN RG7221 DM8J9DC MI TTKLQTJ DM8J9DC MN Angiopoietin-2 (ANGPT2) DM8J9DC MT DTT DM8J9DC MA Modulator DM8J9DC RN Company report (Roche pipeline: July 27, 2017) DM8J9DC RU http://www.roche.com/research_and_development/who_we_are_how_we_work/pipeline.htm DM8J9DC DI DM8J9DC DM8J9DC DN RG7221 DM8J9DC MI TTOHSBA DM8J9DC MN Vascular endothelial growth factor A (VEGFA) DM8J9DC MT DTT DM8J9DC MA Modulator DM8J9DC RN Bispecific antibodies and their applications DM8J9DC RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4687327 DM5RAB9 DI DM5RAB9 DM5RAB9 DN RG-7234 DM5RAB9 MI TT9H85R DM5RAB9 MN Corticosteroid 11-beta-dehydrogenase 2 (HSD11B2) DM5RAB9 MT DTT DM5RAB9 MA Inhibitor DM5RAB9 RN New Therapeutic Strategies for Type 2 Diabetes: Small Molecule Approaches. 2012. Chapter 5. Page(131). DM5RAB9 RU https://books.google.com.hk/books?id=0rmlVGhlJ0IC&pg=PA131&lpg=PA131&dq=RG-7234++New+Therapeutic+Strategies+for+Type+2+Diabetes&source=bl&ots=toqK7w4uiI&sig=sx5iyfQWH2bTCSZmT5aUQiKfPuM&hl=zh-CN&sa=X&ved=0CB0Q6AEwAGoVChMIsZ_k6dDGyAIViLeOCh0oUQpr#v=onepage&q=RG-7234%20%20New%20Therapeutic%20Strategies%20for%20Type%202%20Diabetes&f=false DMB4M6O DI DMB4M6O DMB4M6O DN RG7314 DMB4M6O MI TT4TFGN DMB4M6O MN Vasopressin V1a receptor (V1AR) DMB4M6O MT DTT DMB4M6O MA Modulator DMB4M6O RN Social Communication is an Emerging Target for Pharmacotherapy in Autism Spectrum Disorder - A Review of the Literature on Potential Agents. J Can Acad Child Adolesc Psychiatry. 2014 February; 23(1):20-30. DMB4M6O RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3917666/ DMVXGU0 DI DMVXGU0 DMVXGU0 DN RG7596 DMVXGU0 MI TTBN5I7 DMVXGU0 MN B-cell-specific glycoprotein B29 (CD79B) DMVXGU0 MT DTT DMVXGU0 MA Modulator DMVXGU0 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2852). DMVXGU0 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2852 DMDGPKS DI DMDGPKS DMDGPKS DN RG7625 DMDGPKS MI TTUMQVO DMDGPKS MN Cathepsin S (CTSS) DMDGPKS MT DTT DMDGPKS MA Antagonist DMDGPKS RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMDGPKS RU http://phrma-docs.phrma.org/files/dmfile/medicines-in-development-drug-list-autoimmune-diseases.pdf DM6CNFW DI DM6CNFW DM6CNFW DN RG7686 DM6CNFW MI TTJTSX4 DM6CNFW MN Glypican-3 (GPC3) DM6CNFW MT DTT DM6CNFW RN First-in-man phase I study of GC33, a novel recombinant humanized antibody against glypican-3, in patients with advanced hepatocellular carcinoma. Clin Cancer Res. 2013 Feb 15;19(4):920-8. DM6CNFW RU https://pubmed.ncbi.nlm.nih.gov/23362325 DMK5PYS DI DMK5PYS DMK5PYS DN RG7745 DMK5PYS MI TTF4CAM DMK5PYS MN Influenza Hemagglutinin (Influ HA) DMK5PYS MT DTT DMK5PYS RN Clinical pipeline report, company report or official report of Roche. DMK5PYS RU http://www.roche.com/irp2q13e-annex.pdf DM452RF DI DM452RF DM452RF DN RG7880 DM452RF MI TTLDX4N DM452RF MN Interleukin-22 (IL22) DM452RF MT DTT DM452RF MA Modulator DM452RF RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DM452RF RU http://phrma-docs.phrma.org/files/dmfile/mid-diabetes-drug-list.pdf DM2SWI8 DI DM2SWI8 DM2SWI8 DN RG7888 DM2SWI8 MI TTBW580 DM2SWI8 MN TAX transcriptionally-activated glycoprotein 1 (OX40) DM2SWI8 MT DTT DM2SWI8 RN Anti-tumor efficacy and biomarker evaluation of agonistic anti-OX40 antibodies in preclinical models. J Immunother Cancer. 2014; 2(Suppl 3): P105. DM2SWI8 RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4288389/ DME1YMX DI DME1YMX DME1YMX DN RG7935 DME1YMX MI TT08OSU DME1YMX MN Synuclein alpha (SNCA) DME1YMX MT DTT DME1YMX RN alpha-Synuclein in Parkinson's Disease. Cold Spring Harb Perspect Med. 2012 February; 2(2): a009399. DME1YMX RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3281589/ DMCHZAN DI DMCHZAN DMCHZAN DN RGH-896 DMCHZAN MI TTN9D8E DMCHZAN MN Glutamate receptor ionotropic NMDA 2B (NMDAR2B) DMCHZAN MT DTT DMCHZAN MA Antagonist DMCHZAN RN Emerging drugs in neuropathic pain. Expert Opin Emerg Drugs. 2007 Mar;12(1):113-26. DMCHZAN RU https://pubmed.ncbi.nlm.nih.gov/17355217 DM4AC2F DI DM4AC2F DM4AC2F DN RGI-2001 DM4AC2F MI TT7AKW1 DM4AC2F MN T-cell receptor (TCR) DM4AC2F MT DTT DM4AC2F MA Modulator DM4AC2F RN Pharmacologic expansion of donor-derived, naturally occurring CD4(+)Foxp3(+) regulatory T cells reduces acute graft-versus-host disease lethality without abrogating the graft-versus-leukemia effect in murine models. Biol Blood Marrow Transplant. 2011 Aug;17(8):1154-68. DM4AC2F RU https://pubmed.ncbi.nlm.nih.gov/21145405 DMSF10P DI DMSF10P DMSF10P DN RGN-259 DMSF10P MI TTH5WZF DMSF10P MN Actin (ACT) DMSF10P MT DTT DMSF10P MA Modulator DMSF10P RN Thymosin beta4 significantly improves signs and symptoms of severe dry eye in a phase 2 randomized trial. Cornea. 2015 May;34(5):491-6. DMSF10P RU https://pubmed.ncbi.nlm.nih.gov/25826322 DMBSXR9 DI DMBSXR9 DMBSXR9 DN rhACE2 DMBSXR9 MI TTYRG7F DMBSXR9 MN HUMAN angiotensin-converting enzyme 2 (ACE2) DMBSXR9 MT DTT DMBSXR9 MA Inhibitor DMBSXR9 RN ClinicalTrials.gov (NCT04287686) Recombinant Human Angiotensin-converting Enzyme 2 (rhACE2) as a Treatment for Patients With COVID-19 DMBSXR9 RU https://clinicaltrials.gov/ct2/show/NCT04346797 DMN1EFR DI DMN1EFR DMN1EFR DN RhGDF-5 DMN1EFR MI TT37XV9 DMN1EFR MN Growth/differentiation factor 5 (GDF-5) DMN1EFR MT DTT DMN1EFR MA Modulator DMN1EFR RN Superior effect of MD05, beta-tricalcium phosphate coated with recombinant human growth/differentiation factor-5, compared to conventional bone substitutes in the rat calvarial defect model. J Periodontol. 2006 Sep;77(9):1582-90. DMN1EFR RU https://pubmed.ncbi.nlm.nih.gov/16945037 DMO9QB8 DI DMO9QB8 DMO9QB8 DN R-IFN-1a DMO9QB8 MI TTSYFMA DMO9QB8 MN Interferon alpha/beta receptor 1 (IFNAR1) DMO9QB8 MT DTT DMO9QB8 MA Modulator DMO9QB8 RN Further study on the specificity and incidence of neutralizing antibodies to interferon (IFN) in relapsing remitting multiple sclerosis patients treated with IFN beta-1a or IFN beta-1b. J Neurol Sci.1999 Oct 15;168(2):131-6. DMO9QB8 RU https://pubmed.ncbi.nlm.nih.gov/10526196 DM3L51O DI DM3L51O DM3L51O DN Rilopirox DM3L51O MI TT2J34L DM3L51O MN Arachidonate 5-lipoxygenase (5-LOX) DM3L51O MT DTT DM3L51O MA Inhibitor DM3L51O RN Therapy of seborrheic eczema with an antifungal agent with an antiphlogistic effect. Mycoses. 1991;34 Suppl 1:91-3. DM3L51O RU https://pubmed.ncbi.nlm.nih.gov/1840158 DMSC7TN DI DMSC7TN DMSC7TN DN Rimacalib DMSC7TN MI TTFYL58 DMSC7TN MN CaM-kinase II (CAMK2) DMSC7TN MT DTT DMSC7TN MA Modulator DMSC7TN RN Role for CaMKII inhibition in rheumatoid arthritis: effects on HIF-1-induced VEGF production by rheumatoid synovial fibroblasts. Ann N Y Acad Sci. 2009 Sep;1173:706-11. DMSC7TN RU https://pubmed.ncbi.nlm.nih.gov/19758219 DM2VO97 DI DM2VO97 DM2VO97 DN RK-023 DM2VO97 MI TT30NW6 DM2VO97 MN Chloride channel protein 2 (CLC-2) DM2VO97 MT DTT DM2VO97 MA Modulator DM2VO97 RN Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41. DM2VO97 RU https://www.ncbi.nlm.nih.gov/pubmed/15950434 DMVU1R9 DI DMVU1R9 DMVU1R9 DN RM-1929 DMVU1R9 MI TTGKNB4 DMVU1R9 MN Epidermal growth factor receptor (EGFR) DMVU1R9 MT DTT DMVU1R9 MA Antagonist DMVU1R9 RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMVU1R9 RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DM20CIM DI DM20CIM DM20CIM DN RNF43-721 DM20CIM MI TTD91BL DM20CIM MN RING finger protein 43 (RNF43) DM20CIM MT DTT DM20CIM MA Modulator DM20CIM RN Phase I clinical trial of a novel peptide vaccine in combination with UFT/LV for metastatic colorectal cancer. Exp Ther Med. 2011 Jan-Feb; 2(1): 73-79. DM20CIM RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3440656/ DMDNRU1 DI DMDNRU1 DMDNRU1 DN RNS-60 DMDNRU1 MI TTO7FVG DMDNRU1 MN Heat shock protein 90 (HSP90) DMDNRU1 MT DTT DMDNRU1 MA Modulator DMDNRU1 RN Clinical pipeline report, company report or official report of Revalesio. DMDNRU1 RU http://revalesio.com/about-our-technology/ DM83QCL DI DM83QCL DM83QCL DN Ro 31-7453 DM83QCL MI TTH6V3D DM83QCL MN Cyclin-dependent kinase 1 (CDK1) DM83QCL MT DTT DM83QCL MA Inhibitor DM83QCL RN A comparison of physicochemical property profiles of marketed oral drugs and orally bioavailable anti-cancer protein kinase inhibitors in clinical development. Curr Top Med Chem. 2007;7(14):1408-22. DM83QCL RU https://pubmed.ncbi.nlm.nih.gov/17692029 DM83QCL DI DM83QCL DM83QCL DN Ro 31-7453 DM83QCL MI TT7HF4W DM83QCL MN Cyclin-dependent kinase 2 (CDK2) DM83QCL MT DTT DM83QCL MA Inhibitor DM83QCL RN A comparison of physicochemical property profiles of marketed oral drugs and orally bioavailable anti-cancer protein kinase inhibitors in clinical development. Curr Top Med Chem. 2007;7(14):1408-22. DM83QCL RU https://pubmed.ncbi.nlm.nih.gov/17692029 DM83QCL DI DM83QCL DM83QCL DN Ro 31-7453 DM83QCL MI TT0PG8F DM83QCL MN Cyclin-dependent kinase 4 (CDK4) DM83QCL MT DTT DM83QCL MA Inhibitor DM83QCL RN A comparison of physicochemical property profiles of marketed oral drugs and orally bioavailable anti-cancer protein kinase inhibitors in clinical development. Curr Top Med Chem. 2007;7(14):1408-22. DM83QCL RU https://pubmed.ncbi.nlm.nih.gov/17692029 DMA2UYE DI DMA2UYE DMA2UYE DN Ro-24-7429 DMA2UYE MI TTT3ZC9 DMA2UYE MN Human immunodeficiency virus Tat protein (HIV tat) DMA2UYE MT DTT DMA2UYE MA Modulator DMA2UYE RN A randomized trial of the activity and safety of Ro 24-7429 (Tat antagonist) versus nucleoside for human immunodeficiency virus infection. The AIDS Clinical Trials Group 213 Team. J Infect Dis. 1995 Nov;172(5):1246-52. DMA2UYE RU https://pubmed.ncbi.nlm.nih.gov/7594660 DMV319J DI DMV319J DMV319J DN RO-4905417 DMV319J MI TTS5K8U DMV319J MN P-selectin glycoprotein ligand 1 (SELPLG) DMV319J MT DTT DMV319J RN WO patent application no. 2013,0144,05, Methods. DMV319J RU http://worldwide.espacenet.com/publicationDetails/biblio?DB=worldwide.espacenet.com&II=0&ND=3&adjacent=true&locale=en_EP&FT=D&date=20130131&CC=WO&NR=2013014405A2&KC=A2 DMXA6B3 DI DMXA6B3 DMXA6B3 DN RO-4929097 DMXA6B3 MI TT9W8GU DMXA6B3 MN Gamma-secretase (GS) DMXA6B3 MT DTT DMXA6B3 MA Modulator DMXA6B3 RN Phase I study of RO4929097, a gamma secretase inhibitor of Notch signaling, in patients with refractory metastatic or locally advanced solid tumors. J Clin Oncol. 2012 Jul 1;30(19):2348-53. DMXA6B3 RU https://pubmed.ncbi.nlm.nih.gov/22529266 DMNTC7O DI DMNTC7O DMNTC7O DN RO-4995819 DMNTC7O MI TTXJ47W DMNTC7O MN Metabotropic glutamate receptor 2 (mGluR2) DMNTC7O MT DTT DMNTC7O MA Modulator DMNTC7O RN Novel glutamatergic drugs for the treatment of mood disorders. Neuropsychiatr Dis Treat. 2013; 9: 1101-1112. DMNTC7O RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3747027/ DMNTC7O DI DMNTC7O DMNTC7O DN RO-4995819 DMNTC7O MI TT8A9EF DMNTC7O MN Metabotropic glutamate receptor 3 (mGluR3) DMNTC7O MT DTT DMNTC7O MA Modulator DMNTC7O RN Novel glutamatergic drugs for the treatment of mood disorders. Neuropsychiatr Dis Treat. 2013; 9: 1101-1112. DMNTC7O RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3747027/ DMZJREM DI DMZJREM DMZJREM DN RO-4998452 DMZJREM MI TTLWPVF DMZJREM MN Sodium/glucose cotransporter 2 (SGLT2) DMZJREM MT DTT DMZJREM MA Modulator DMZJREM RN A novel and selective sodium-glucose cotransporter-2 inhibitor, tofogliflozin, improves glycaemic control and lowers body weight in patients with type 2 diabetes mellitus.Diabetes Obes Metab.2015 Oct;17(10):984-93. DMZJREM RU https://www.ncbi.nlm.nih.gov/pubmed/26179482 DM3U9BY DI DM3U9BY DM3U9BY DN RO-5126766 DM3U9BY MI TTROQ37 DM3U9BY MN MAPK/ERK kinase kinase (MAP3K) DM3U9BY MT DTT DM3U9BY MA Modulator DM3U9BY RN The dual RAF/MEK inhibitor CH5126766/RO5126766 may be a potential therapy for RAS-mutated tumor cells.PLoS One.2014 Nov 25;9(11):e113217. DM3U9BY RU https://www.ncbi.nlm.nih.gov/pubmed/25422890 DM3U9BY DI DM3U9BY DM3U9BY DN RO-5126766 DM3U9BY MI TTQ9K3Y DM3U9BY MN Serine/threonine-protein kinase Raf (RAF) DM3U9BY MT DTT DM3U9BY MA Modulator DM3U9BY RN The dual RAF/MEK inhibitor CH5126766/RO5126766 may be a potential therapy for RAS-mutated tumor cells.PLoS One.2014 Nov 25;9(11):e113217. DM3U9BY RU https://www.ncbi.nlm.nih.gov/pubmed/25422890 DMUB3OY DI DMUB3OY DMUB3OY DN RO-5323441 DMUB3OY MI TT48I1Y DMUB3OY MN Placenta growth factor (PlGF) DMUB3OY MT DTT DMUB3OY MA Inhibitor DMUB3OY RN RO5323441, a humanized monoclonal antibody against the placenta growth factor, blocks PlGF-induced VEGFR-1 phosphorylation in vitro and tumor growth in vivo. Cancer Research. 01/2011. DMUB3OY RU http://cancerres.aacrjournals.org/content/70/8_Supplement/1370.abstract DMD3WNP DI DMD3WNP DMD3WNP DN RO5520985 DMD3WNP MI TTKLQTJ DMD3WNP MN Angiopoietin-2 (ANGPT2) DMD3WNP MT DTT DMD3WNP MA Modulator DMD3WNP RN Bispecific antibodies rise again. Nat Rev Drug Discov. 2014 Nov;13(11):799-801. DMD3WNP RU https://www.ncbi.nlm.nih.gov/pubmed/25359367 DMD3WNP DI DMD3WNP DMD3WNP DN RO5520985 DMD3WNP MI TTOHSBA DMD3WNP MN Vascular endothelial growth factor A (VEGFA) DMD3WNP MT DTT DMD3WNP MA Modulator DMD3WNP RN Bispecific antibodies rise again. Nat Rev Drug Discov. 2014 Nov;13(11):799-801. DMD3WNP RU https://www.ncbi.nlm.nih.gov/pubmed/25359367 DM8A120 DI DM8A120 DM8A120 DN RO7121661 DM8A120 MI TT1RWL7 DM8A120 MN Hepatitis A virus cellular receptor 2 (TIM3) DM8A120 MT DTT DM8A120 MA Inhibitor DM8A120 RN Bispecific antibodies: a mechanistic review of the pipeline. Nat Rev Drug Discov. 2019 Aug;18(8):585-608. DM8A120 RU https://pubmed.ncbi.nlm.nih.gov/31175342 DM8A120 DI DM8A120 DM8A120 DN RO7121661 DM8A120 MI TTNBFWK DM8A120 MN Programmed cell death protein 1 (PD-1) DM8A120 MT DTT DM8A120 MA Inhibitor DM8A120 RN Bispecific antibodies: a mechanistic review of the pipeline. Nat Rev Drug Discov. 2019 Aug;18(8):585-608. DM8A120 RU https://pubmed.ncbi.nlm.nih.gov/31175342 DMSTH01 DI DMSTH01 DMSTH01 DN Rocilinostat DMSTH01 MI TTBH0VX DMSTH01 MN Histone deacetylase (HDAC) DMSTH01 MT DTT DMSTH01 MA Inhibitor DMSTH01 RN National Cancer Institute Drug Dictionary (drug id 698408). DMSTH01 RU http://www.cancer.gov/publications/dictionaries/cancer-drug?cdrid=698408 DMYEZ5J DI DMYEZ5J DMYEZ5J DN Romilkimab DMYEZ5J MI TT0GVCH DMYEZ5J MN Interleukin-13 (IL13) DMYEZ5J MT DTT DMYEZ5J MA Inhibitor DMYEZ5J RN A randomised, double-blind, placebo-controlled, 24-week, phase II, proof-of-concept study of romilkimab (SAR156597) in early diffuse cutaneous systemic sclerosis. Ann Rheum Dis. 2020 Dec;79(12):1600-1607. DMYEZ5J RU https://pubmed.ncbi.nlm.nih.gov/32963047 DMYEZ5J DI DMYEZ5J DMYEZ5J DN Romilkimab DMYEZ5J MI TTLGTKB DMYEZ5J MN Interleukin-4 (IL4) DMYEZ5J MT DTT DMYEZ5J MA Inhibitor DMYEZ5J RN A randomised, double-blind, placebo-controlled, 24-week, phase II, proof-of-concept study of romilkimab (SAR156597) in early diffuse cutaneous systemic sclerosis. Ann Rheum Dis. 2020 Dec;79(12):1600-1607. DMYEZ5J RU https://pubmed.ncbi.nlm.nih.gov/32963047 DMBJN19 DI DMBJN19 DMBJN19 DN Rontalizumab DMBJN19 MI TT95SOA DMBJN19 MN Interferon alpha (IFNA) DMBJN19 MT DTT DMBJN19 RN Clinical pipeline report, company report or official report of Genentech (2011). DMBJN19 RU http://www.gene.com/gene/index.jsp DMKQXDB DI DMKQXDB DMKQXDB DN Rostafuroxin DMKQXDB MI TTQ38E9 DMKQXDB MN Sodium/potassium-transporting ATPase (SPT ATPase) DMKQXDB MT DTT DMKQXDB MA Modulator DMKQXDB RN Rostafuroxin: an ouabain antagonist that corrects renal and vascular Na+-K+- ATPase alterations in ouabain and adducin-dependent hypertension. Am J Physiol Regul Integr Comp Physiol. 2006 Mar;290(3):R529-35. DMKQXDB RU https://pubmed.ncbi.nlm.nih.gov/16467500 DMXB9RS DI DMXB9RS DMXB9RS DN ROTIGAPTIDE DMXB9RS MI TTJO6E9 DMXB9RS MN Gap junction protein (GJP) DMXB9RS MT DTT DMXB9RS MA Modulator DMXB9RS RN The antiarrhythmic peptide rotigaptide (ZP123) increases gap junction intercellular communication in cardiac myocytes and HeLa cells expressing connexin 43. Br J Pharmacol. 2006 Mar;147(5):486-95. DMXB9RS RU https://pubmed.ncbi.nlm.nih.gov/16415913 DMIZMYQ DI DMIZMYQ DMIZMYQ DN Roxatidine DMIZMYQ MI DEJVYAZ DMIZMYQ MN Cytochrome P450 2A6 (CYP2A6) DMIZMYQ MT DME DMIZMYQ MA Metabolism DMIZMYQ RN Cytochrome P450 enzymes involved in the metabolic pathway of the histamine 2 (H2)-receptor antagonist roxatidine acetate by human liver microsomes. Arzneimittelforschung. 2001;51(8):651-8. DMIZMYQ RU https://www.ncbi.nlm.nih.gov/pubmed/?term=11556126 DMIZMYQ DI DMIZMYQ DMIZMYQ DN Roxatidine DMIZMYQ MI DECB0K3 DMIZMYQ MN Cytochrome P450 2D6 (CYP2D6) DMIZMYQ MT DME DMIZMYQ MA Metabolism DMIZMYQ RN Cytochrome P450 enzymes involved in the metabolic pathway of the histamine 2 (H2)-receptor antagonist roxatidine acetate by human liver microsomes. Arzneimittelforschung. 2001;51(8):651-8. DMIZMYQ RU https://www.ncbi.nlm.nih.gov/pubmed/?term=11556126 DM15QL9 DI DM15QL9 DM15QL9 DN ROXINDOLE DM15QL9 MI TTEX248 DM15QL9 MN Dopamine D2 receptor (D2R) DM15QL9 MT DTT DM15QL9 MA Inhibitor DM15QL9 RN Indolebutylamines as selective 5-HT(1A) agonists. J Med Chem. 2004 Sep 9;47(19):4677-83. DM15QL9 RU https://pubmed.ncbi.nlm.nih.gov/15341483 DMK0NGB DI DMK0NGB DMK0NGB DN Rozanolixizumab DMK0NGB MI TTPY4SE DMK0NGB MN Immunoglobulin Fc receptor (FCR) DMK0NGB MT DTT DMK0NGB MA Antagonist DMK0NGB RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMK0NGB RU http://phrma-docs.phrma.org/files/dmfile/MID_Neurological-Disorders-Drug-List_2018.pdf DM4N6PF DI DM4N6PF DM4N6PF DN RP-49356 DM4N6PF MI TT1VOHK DM4N6PF MN Potassium channel unspecific (KC) DM4N6PF MT DTT DM4N6PF MA Opener DM4N6PF RN Effects of pinacidil, RP 49356 and nicorandil on ATP-sensitive potassium channels in insulin-secreting cells. Br J Pharmacol. 1990 Mar;99(3):487-92. DM4N6PF RU https://pubmed.ncbi.nlm.nih.gov/2158844 DMKUE8O DI DMKUE8O DMKUE8O DN RP5063 DMKUE8O MI TTSQIFT DMKUE8O MN 5-HT 1A receptor (HTR1A) DMKUE8O MT DTT DMKUE8O MA Antagonist DMKUE8O RN Drug Development in Schizophrenia: Summary and Table. Pharmaceutical Medicine October 2014, Volume 28, Issue 5, pp 265-271 DMKUE8O RU http://link.springer.com/article/10.1007%2Fs40290-014-0070-6 DMKUE8O DI DMKUE8O DMKUE8O DN RP5063 DMKUE8O MI TTJQOD7 DMKUE8O MN 5-HT 2A receptor (HTR2A) DMKUE8O MT DTT DMKUE8O MA Partial agonist DMKUE8O RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMKUE8O RU http://phrma-docs.phrma.org/files/dmfile/MID_Mental-Illness-2017-Drug-List_Final.pdf DMKUE8O DI DMKUE8O DMKUE8O DN RP5063 DMKUE8O MI TTO9X1H DMKUE8O MN 5-HT 7 receptor (HTR7) DMKUE8O MT DTT DMKUE8O MA Partial agonist DMKUE8O RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMKUE8O RU http://phrma-docs.phrma.org/files/dmfile/MID_Mental-Illness-2017-Drug-List_Final.pdf DMKUE8O DI DMKUE8O DMKUE8O DN RP5063 DMKUE8O MI TTEX248 DMKUE8O MN Dopamine D2 receptor (D2R) DMKUE8O MT DTT DMKUE8O MA Antagonist DMKUE8O RN Drug Development in Schizophrenia: Summary and Table. Pharmaceutical Medicine October 2014, Volume 28, Issue 5, pp 265-271 DMKUE8O RU http://link.springer.com/article/10.1007%2Fs40290-014-0070-6 DMKUE8O DI DMKUE8O DMKUE8O DN RP5063 DMKUE8O MI TT4C8EA DMKUE8O MN Dopamine D3 receptor (D3R) DMKUE8O MT DTT DMKUE8O MA Partial agonist DMKUE8O RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMKUE8O RU http://phrma-docs.phrma.org/files/dmfile/MID_Mental-Illness-2017-Drug-List_Final.pdf DMKUE8O DI DMKUE8O DMKUE8O DN RP5063 DMKUE8O MI TTE0A2F DMKUE8O MN Dopamine D4 receptor (D4R) DMKUE8O MT DTT DMKUE8O MA Partial agonist DMKUE8O RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMKUE8O RU http://phrma-docs.phrma.org/files/dmfile/MID_Mental-Illness-2017-Drug-List_Final.pdf DMKUE8O DI DMKUE8O DMKUE8O DN RP5063 DMKUE8O MI TTTIBOJ DMKUE8O MN Histamine H1 receptor (H1R) DMKUE8O MT DTT DMKUE8O MA Partial agonist DMKUE8O RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMKUE8O RU http://phrma-docs.phrma.org/files/dmfile/MID_Mental-Illness-2017-Drug-List_Final.pdf DMKUE8O DI DMKUE8O DMKUE8O DN RP5063 DMKUE8O MI TT8G3Z7 DMKUE8O MN Serotoninnorepinephrinedopamine reuptake (SNDR) DMKUE8O MT DTT DMKUE8O MA Partial agonist DMKUE8O RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMKUE8O RU http://phrma-docs.phrma.org/files/dmfile/MID_Mental-Illness-2017-Drug-List_Final.pdf DMYILGK DI DMYILGK DMYILGK DN RP6530 DMYILGK MI TTGBPJE DMYILGK MN PI3-kinase delta (PIK3CD) DMYILGK MT DTT DMYILGK MA Inhibitor DMYILGK RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMYILGK RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DM4L5VJ DI DM4L5VJ DM4L5VJ DN R-phenserine DM4L5VJ MI TT1RS9F DM4L5VJ MN Acetylcholinesterase (AChE) DM4L5VJ MT DTT DM4L5VJ MA Inhibitor DM4L5VJ RN An overview of phenserine tartrate, a novel acetylcholinesterase inhibitor for the treatment of Alzheimer's disease. Curr Alzheimer Res. 2005 Jul;2(3):281-90. DM4L5VJ RU https://pubmed.ncbi.nlm.nih.gov/15974893 DMSJU5B DI DMSJU5B DMSJU5B DN RP-L102 DMSJU5B MI TTV5HJS DMSJU5B MN Fanconi anemia group A protein (FANCA) DMSJU5B MT DTT DMSJU5B MA Replacement DMSJU5B RN Clinical pipeline report, company report or official report of Rocket Pharmaceuticals. DMSJU5B RU https://rocketpharma.com/our-disease-focus/ DMLD4VQ DI DMLD4VQ DMLD4VQ DN RPL-554 DMLD4VQ MI TTZCG4L DMLD4VQ MN Phosphodiesterase 3 (PDE3) DMLD4VQ MT DTT DMLD4VQ MA Modulator DMLD4VQ RN Efficacy and safety of RPL554, a dual PDE3 and PDE4 inhibitor, in healthy volunteers and in patients with asthma or chronic obstructive pulmonary disease: findings from four clinical trials.Lancet Respir Med.2013 Nov;1(9):714-27. DMLD4VQ RU https://www.ncbi.nlm.nih.gov/pubmed/24429275 DM0BFJ5 DI DM0BFJ5 DM0BFJ5 DN RPSGL-Ig DM0BFJ5 MI TTE5VG0 DM0BFJ5 MN P-selectin (SELP) DM0BFJ5 MT DTT DM0BFJ5 MA Inhibitor DM0BFJ5 RN rPSGL-1-Ig, a recombinant PSGL-1-Ig fusion protein, ameliorates LPS-induced acute lung injury in mice by inhibiting neutrophil migration. Cell Mol Biol (Noisy-le-grand). 2015 Feb 28;61(1):1-6. DM0BFJ5 RU https://pubmed.ncbi.nlm.nih.gov/25817339 DMBHN4K DI DMBHN4K DMBHN4K DN RQ-00000005 DMBHN4K MI TTWDC17 DMBHN4K MN Growth hormone secretagogue receptor 1 (GHSR) DMBHN4K MT DTT DMBHN4K MA Agonist DMBHN4K RN Hypotensive effects of ghrelin receptor agonists mediated through a novel receptor. Br J Pharmacol. 2014 Mar;171(5):1275-86. DMBHN4K RU https://pubmed.ncbi.nlm.nih.gov/24670149 DMMYTRU DI DMMYTRU DMMYTRU DN RQ-00000007 (oral) DMMYTRU MI TT79WV3 DMMYTRU MN Prostaglandin E2 receptor EP4 (PTGER4) DMMYTRU MT DTT DMMYTRU MA Antagonist DMMYTRU RN Clinical pipeline report, company report or official report of Avarx. DMMYTRU RU http://www.avarx.com/AvaRx/SubDomains/bucket5733245651167129819/Listings/bucket2137138075456035728/Public.Listing.display.html DMSH108 DI DMSH108 DMSH108 DN R-roscovitine DMSH108 MI TTMBO1Z DMSH108 MN Cyclin-dependent kinase (CDK) DMSH108 MT DTT DMSH108 MA Inhibitor DMSH108 RN Therapeutic efficacy of seliciclib in combination with ionizing radiation for human nasopharyngeal carcinoma.Clin Cancer Res. 2009 Jun 1;15(11):3716-24. DMSH108 RU https://pubmed.ncbi.nlm.nih.gov/19470731 DMSH108 DI DMSH108 DMSH108 DN R-roscovitine DMSH108 MI TTH6V3D DMSH108 MN Cyclin-dependent kinase 1 (CDK1) DMSH108 MT DTT DMSH108 MA Inhibitor DMSH108 RN Cell cycle kinases as therapeutic targets for cancer. Nat Rev Drug Discov. 2009 Jul;8(7):547-66. DMSH108 RU https://pubmed.ncbi.nlm.nih.gov/19568282 DMSH108 DI DMSH108 DMSH108 DN R-roscovitine DMSH108 MI TT7HF4W DMSH108 MN Cyclin-dependent kinase 2 (CDK2) DMSH108 MT DTT DMSH108 MA Inhibitor DMSH108 RN Cell cycle kinases as therapeutic targets for cancer. Nat Rev Drug Discov. 2009 Jul;8(7):547-66. DMSH108 RU https://pubmed.ncbi.nlm.nih.gov/19568282 DMSH108 DI DMSH108 DMSH108 DN R-roscovitine DMSH108 MI TTQYF7G DMSH108 MN Cyclin-dependent kinase 7 (CDK7) DMSH108 MT DTT DMSH108 MA Inhibitor DMSH108 RN Cell cycle kinases as therapeutic targets for cancer. Nat Rev Drug Discov. 2009 Jul;8(7):547-66. DMSH108 RU https://pubmed.ncbi.nlm.nih.gov/19568282 DMSH108 DI DMSH108 DMSH108 DN R-roscovitine DMSH108 MI DEPKLMQ DMSH108 MN Cytochrome P450 2B6 (CYP2B6) DMSH108 MT DME DMSH108 MA Metabolism DMSH108 RN Metabolism of the trisubstituted purine cyclin-dependent kinase inhibitor seliciclib (R-roscovitine) in vitro and in vivo. Drug Metab Dispos. 2008 Mar;36(3):561-70. DMSH108 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=18048486 DMSH108 DI DMSH108 DMSH108 DN R-roscovitine DMSH108 MI DE4LYSA DMSH108 MN Cytochrome P450 3A4 (CYP3A4) DMSH108 MT DME DMSH108 MA Metabolism DMSH108 RN Metabolism of the trisubstituted purine cyclin-dependent kinase inhibitor seliciclib (R-roscovitine) in vitro and in vivo. Drug Metab Dispos. 2008 Mar;36(3):561-70. DMSH108 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=18048486 DMSH108 DI DMSH108 DMSH108 DN R-roscovitine DMSH108 MI DTUGYRD DMSH108 MN P-glycoprotein 1 (ABCB1) DMSH108 MT DTP DMSH108 MA Substrate DMSH108 RN ATP-binding cassette B1 transports seliciclib (R-roscovitine), a cyclin-dependent kinase inhibitor. Drug Metab Dispos. 2010 Nov;38(11):2000-6. DMSH108 RU https://doi.org/10.1124/dmd.110.032805 DMGLCVU DI DMGLCVU DMGLCVU DN R-salbutamol sulphate DMGLCVU MI TT2CJVK DMGLCVU MN Adrenergic receptor beta-2 (ADRB2) DMGLCVU MT DTT DMGLCVU MA Agonist DMGLCVU RN Pharmacokinetics and extrapulmonary beta 2 adrenoceptor activity of nebulised racemic salbutamol and its R and S isomers in healthy volunteers. Thorax. 1997 Oct;52(10):849-52. DMGLCVU RU https://pubmed.ncbi.nlm.nih.gov/9404370 DMAJH75 DI DMAJH75 DMAJH75 DN RSV-604 DMAJH75 MI TT25A0I DMAJH75 MN Respiratory syncytial virus protein N (RSV N) DMAJH75 MT DTT DMAJH75 MA Inhibitor DMAJH75 RN Mechanism of action for respiratory syncytial virus inhibitor RSV604. Antimicrob Agents Chemother. 2015 Feb;59(2):1080-7. DMAJH75 RU https://pubmed.ncbi.nlm.nih.gov/25451060 DM3FS1G DI DM3FS1G DM3FS1G DN RT-001 DM3FS1G MI TTB52WU DM3FS1G MN Bacterial Botulinum toxin A (Bact botA) DM3FS1G MT DTT DM3FS1G MA Modulator DM3FS1G RN Clinical pipeline report, company report or official report of Revance Therapeutics. DM3FS1G RU http://www.revance.com/mechanism-of-action-rt001/ DM8DVC9 DI DM8DVC9 DM8DVC9 DN RT-400 DM8DVC9 MI TTIY658 DM8DVC9 MN Corticotropin-releasing factor receptor 2 (CRHR2) DM8DVC9 MT DTT DM8DVC9 MA Agonist DM8DVC9 RN Advances in therapeutic peptides targeting G protein-coupled receptors. Nat Rev Drug Discov. 2020 Jun;19(6):389-413. DM8DVC9 RU https://pubmed.ncbi.nlm.nih.gov/32494050 DM45NHF DI DM45NHF DM45NHF DN RTR-003632 DM45NHF MI DESDN74 DM45NHF MN Serum paraoxonase/arylesterase 1 (PON1) DM45NHF MT DME DM45NHF MA Metabolism DM45NHF RN Human serum paraoxonase (PON1) isozymes Q and R hydrolyze lactones and cyclic carbonate esters. Drug Metab Dispos. 2000 Nov;28(11):1335-42. DM45NHF RU https://www.ncbi.nlm.nih.gov/pubmed/?term=11038162 DMVCXZK DI DMVCXZK DMVCXZK DN Rupintrivir DMVCXZK MI TTGW0DV DMVCXZK MN Rhinovirus Protease 3C (HRV P3C) DMVCXZK MT DTT DMVCXZK MA Modulator DMVCXZK RN Enterovirus 71 and coxsackievirus A16 3C proteases: binding to rupintrivir and their substrates and anti-hand, foot, and mouth disease virus drug design. J Virol. 2011 Oct;85(19):10319-31. DMVCXZK RU https://pubmed.ncbi.nlm.nih.gov/21795339 DMSW5XJ DI DMSW5XJ DMSW5XJ DN RV521 DMSW5XJ MI TT57ID8 DMSW5XJ MN Respiratory syncytial virus protein F (RSV F) DMSW5XJ MT DTT DMSW5XJ MA Inhibitor DMSW5XJ RN Discovery of Sisunatovir (RV521), an Inhibitor of Respiratory Syncytial Virus Fusion. J Med Chem. 2021 Apr 8;64(7):3658-3676. DMSW5XJ RU https://pubmed.ncbi.nlm.nih.gov/33729773 DM652CM DI DM652CM DM652CM DN RV-568 DM652CM MI TTU8W4S DM652CM MN Protein kinase (PK) DM652CM MT DTT DM652CM MA Inhibitor DM652CM RN Investigational p38 inhibitors for the treatment of chronic obstructive pulmonary disease. Expert Opin Investig Drugs. 2015 Mar;24(3):383-92. DM652CM RU https://pubmed.ncbi.nlm.nih.gov/25599809 DM3C9F8 DI DM3C9F8 DM3C9F8 DN RVT-505 DM3C9F8 MI TT037IE DM3C9F8 MN Aryl hydrocarbon receptor (AHR) DM3C9F8 MT DTT DM3C9F8 MA Modulator DM3C9F8 RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DM3C9F8 RU http://phrma-docs.phrma.org/files/dmfile/MID_Skin_Diseases_2018_9_FINAL.pdf DMTBAV3 DI DMTBAV3 DMTBAV3 DN RX-0201 DMTBAV3 MI TTWTSCV DMTBAV3 MN RAC-alpha serine/threonine-protein kinase (AKT1) DMTBAV3 MT DTT DMTBAV3 MA Inhibitor DMTBAV3 RN CenterWatch. Drugs in Clinical Trials Database. CenterWatch. 2008. DMTBAV3 RU http://www.centerwatch.com/ DME8ARP DI DME8ARP DME8ARP DN RX-3117 DME8ARP MI TT6S2FE DME8ARP MN DNA [cytosine-5]-methyltransferase 1 (DNMT1) DME8ARP MT DTT DME8ARP MA Inhibitor DME8ARP RN Metabolism, mechanism of action and sensitivity profile of fluorocyclopentenylcytosine (RX-3117; TV-1360). Invest New Drugs. 2013 Dec;31(6):1444-57. DME8ARP RU https://pubmed.ncbi.nlm.nih.gov/24048768 DMBOZPH DI DMBOZPH DMBOZPH DN RX-5902 DMBOZPH MI TTOTSW1 DMBOZPH MN ATP-dependent RNA helicase DDX5 (DDX5) DMBOZPH MT DTT DMBOZPH MA Modulator DMBOZPH RN Company report (Rexahn) DMBOZPH RU http://investors.rexahn.com/releasedetail.cfm?releaseid=895381 DMBOZPH DI DMBOZPH DMBOZPH DN RX-5902 DMBOZPH MI TTZKPVC DMBOZPH MN Phosphorylated p68 RNA helicase (pDDX5) DMBOZPH MT DTT DMBOZPH MA Inhibitor DMBOZPH RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMBOZPH RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DMXG9ES DI DMXG9ES DMXG9ES DN RXI-109 DMXG9ES MI TTIL516 DMXG9ES MN CCN2 messenger RNA (CCN2 mRNA) DMXG9ES MT DTT DMXG9ES MA Inhibitor DMXG9ES RN The current state and future directions of RNAi-based therapeutics. Nat Rev Drug Discov. 2019 Jun;18(6):421-446. DMXG9ES RU https://pubmed.ncbi.nlm.nih.gov/30846871 DM4KWEF DI DM4KWEF DM4KWEF DN S-0509 DM4KWEF MI TTVFO0U DM4KWEF MN Gastrin/cholecystokinin type B receptor (CCKBR) DM4KWEF MT DTT DM4KWEF MA Antagonist DM4KWEF RN Selective action of a CCK-B/gastrin receptor antagonist, S-0509, on pentagastrin-, peptone meal- and beer-stimulated gastric acid secretion in dogs. Aliment Pharmacol Ther. 2000 Apr;14(4):479-88. DM4KWEF RU https://pubmed.ncbi.nlm.nih.gov/10759628 DM9KTSG DI DM9KTSG DM9KTSG DN S-1360 DM9KTSG MI TT5FH9Y DM9KTSG MN Human immunodeficiency virus Integrase (HIV IN) DM9KTSG MT DTT DM9KTSG MA Inhibitor DM9KTSG RN HIV-1 integrase inhibitors: an emerging clinical reality. Drugs R D. 2007;8(3):155-68. DM9KTSG RU https://pubmed.ncbi.nlm.nih.gov/17472411 DMKTLSD DI DMKTLSD DMKTLSD DN S-15535 DMKTLSD MI TTSQIFT DMKTLSD MN 5-HT 1A receptor (HTR1A) DMKTLSD MT DTT DMKTLSD MA Antagonist DMKTLSD RN S 15535, a benzodioxopiperazine acting as presynaptic agonist and postsynaptic 5-HT1A receptor antagonist, prevents the impairment of spatial learning caused by intrahippocampal scopolamine. Br J Pharmacol. 1999 Nov;128(6):1207-14. DMKTLSD RU https://pubmed.ncbi.nlm.nih.gov/10578133 DML2D30 DI DML2D30 DML2D30 DN S-16924 DML2D30 MI TTSQIFT DML2D30 MN 5-HT 1A receptor (HTR1A) DML2D30 MT DTT DML2D30 MA Modulator DML2D30 RN S 16924 ((R)-2-[1-[2-(2,3-dihydro-benzo[1,4] dioxin-5-Yloxy)-ethyl]-pyrrolidin-3yl]-1-(4-fluoro-phenyl)-ethanone), a novel, potential antipsychotic with marked serotonin (5-HT)1A agonist properties: I. Receptorial and neurochemical profile in comparison with clozapine and haloperidol. J Pharmacol Exp Ther. 1998 Sep;286(3):1341-55. DML2D30 RU https://pubmed.ncbi.nlm.nih.gov/9732398 DMTAX8B DI DMTAX8B DMTAX8B DN S-2150 DMTAX8B MI TT5HONZ DMTAX8B MN Calcium channel unspecific (CaC) DMTAX8B MT DTT DMTAX8B MA Modulator DMTAX8B RN Pharmacodynamics of S-2150, a simultaneous calcium-blocking and alpha1-inhibiting antihypertensive drug, in rats. J Pharm Pharmacol. 2000 Mar;52(3):273-80. DMTAX8B RU https://pubmed.ncbi.nlm.nih.gov/10757414 DM26IH8 DI DM26IH8 DM26IH8 DN S-297995 DM26IH8 MI TTN4QDT DM26IH8 MN Opioid receptor (OPR) DM26IH8 MT DTT DM26IH8 MA Antagonist DM26IH8 RN Clinical pipeline report, company report or official report of Shionogi (2011). DM26IH8 RU http://www.shionogi.co.jp/index_e.html DMU7ZMH DI DMU7ZMH DMU7ZMH DN S-364735 DMU7ZMH MI TT5FH9Y DMU7ZMH MN Human immunodeficiency virus Integrase (HIV IN) DMU7ZMH MT DTT DMU7ZMH MA Inhibitor DMU7ZMH RN The naphthyridinone GSK364735 is a novel, potent human immunodeficiency virus type 1 integrase inhibitor and antiretroviral. Antimicrob Agents Chemother. 2008 Mar;52(3):901-8. DMU7ZMH RU https://pubmed.ncbi.nlm.nih.gov/18160521 DMD8XOY DI DMD8XOY DMD8XOY DN S-38093 DMD8XOY MI TT9JNIC DMD8XOY MN Histamine H3 receptor (H3R) DMD8XOY MT DTT DMD8XOY MA Antagonist DMD8XOY RN Histamine H3 Receptors and Sleep-Wake Regulation. JPET January 2011 vol. 336 no. 1 17-23. DMD8XOY RU http://jpet.aspetjournals.org/content/336/1/17.full DMXDVNZ DI DMXDVNZ DMXDVNZ DN S-555739 DMXDVNZ MI TTNVEIR DMXDVNZ MN Prostaglandin D2 receptor (PTGDR) DMXDVNZ MT DTT DMXDVNZ MA Antagonist DMXDVNZ RN Clinical pipeline report, company report or official report of Shionogi (2011). DMXDVNZ RU http://www.shionogi.co.jp/index_e.html DM3GRKY DI DM3GRKY DM3GRKY DN S-707106 DM3GRKY MI TTCBFJO DM3GRKY MN Insulin receptor (INSR) DM3GRKY MT DTT DM3GRKY MA Modulator DM3GRKY RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1800). DM3GRKY RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1800 DMZGNOJ DI DMZGNOJ DMZGNOJ DN S-777469 DMZGNOJ MI TTMSFAW DMZGNOJ MN Cannabinoid receptor 2 (CB2) DMZGNOJ MT DTT DMZGNOJ MA Agonist DMZGNOJ RN Emerging drugs for atopic dermatitis. Expert Opin Emerg Drugs. 2009 Mar;14(1):165-79. DMZGNOJ RU https://pubmed.ncbi.nlm.nih.gov/19216704 DMRZA6G DI DMRZA6G DMRZA6G DN S-8921 DMRZA6G MI TTPI1M5 DMRZA6G MN Ileal sodium/bile acid cotransporter (SLC10A2) DMRZA6G MT DTT DMRZA6G MA Inhibitor DMRZA6G RN Inhibition of ileal Na+/bile acid cotransporter by S-8921 reduces serum cholesterol and prevents atherosclerosis in rabbits. Arterioscler Thromb Vasc Biol. 1998 Aug;18(8):1304-11. DMRZA6G RU https://pubmed.ncbi.nlm.nih.gov/9714138 DMBZO8N DI DMBZO8N DMBZO8N DN Sabarubicin DMBZO8N MI TT0IHXV DMBZO8N MN DNA topoisomerase II (TOP2) DMBZO8N MT DTT DMBZO8N MA Modulator DMBZO8N RN Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41. DMBZO8N RU https://www.ncbi.nlm.nih.gov/pubmed/15950434 DMKDP57 DI DMKDP57 DMKDP57 DN Safotibant DMKDP57 MI TTG5QIA DMKDP57 MN B1 bradykinin receptor (BDKRB1) DMKDP57 MT DTT DMKDP57 MA Modulator DMKDP57 RN The role of kinin receptors in cancer and therapeutic opportunities. Cancer Letters Volume 345, Issue 1, 1 April 2014, Pages 27-38. DMKDP57 RU http://www.sciencedirect.com/science/article/pii/S030438351300829X DMRFK0B DI DMRFK0B DMRFK0B DN SAGE-217b DMRFK0B MI TTGXH6N DMRFK0B MN GABA(A) receptor delta (GABRD) DMRFK0B MT DTT DMRFK0B MA Immunostimulant DMRFK0B RN Antibodies and venom peptides: new modalities for ion channels. Nat Rev Drug Discov. 2019 May;18(5):339-357. DMRFK0B RU https://pubmed.ncbi.nlm.nih.gov/30728472 DM5NC39 DI DM5NC39 DM5NC39 DN SAGE-324 DM5NC39 MI TTCI43M DM5NC39 MN GABA(A) receptor (GABAR) DM5NC39 MT DTT DM5NC39 MA Modulator DM5NC39 RN Antibodies and venom peptides: new modalities for ion channels. Nat Rev Drug Discov. 2019 May;18(5):339-357. DM5NC39 RU https://pubmed.ncbi.nlm.nih.gov/30728472 DM9RC7D DI DM9RC7D DM9RC7D DN SAGE-718 DM9RC7D MI TT9IK2Z DM9RC7D MN N-methyl-D-aspartate receptor (NMDAR) DM9RC7D MT DTT DM9RC7D MA Modulator DM9RC7D RN Antibodies and venom peptides: new modalities for ion channels. Nat Rev Drug Discov. 2019 May;18(5):339-357. DM9RC7D RU https://pubmed.ncbi.nlm.nih.gov/30728472 DMRSU4X DI DMRSU4X DMRSU4X DN Salirasib DMRSU4X MI TTW2R9X DMRSU4X MN GTPase NRas (NRAS) DMRSU4X MT DTT DMRSU4X MA Antagonist DMRSU4X RN The Ras inhibitor farnesylthiosalicylic acid (Salirasib) disrupts the spatiotemporal localization of active Ras: a potential treatment for cancer. Methods Enzymol. 2008;439:467-89. DMRSU4X RU https://pubmed.ncbi.nlm.nih.gov/18374183 DMRSU4X DI DMRSU4X DMRSU4X DN Salirasib DMRSU4X MI TTCJG29 DMRSU4X MN Serine/threonine-protein kinase mTOR (mTOR) DMRSU4X MT DTT DMRSU4X MA Modulator DMRSU4X RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2109). DMRSU4X RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2109 DMQVC3E DI DMQVC3E DMQVC3E DN Salvianolic acid B DMQVC3E MI TTZHNQA DMQVC3E MN Insulin-like growth factor-binding protein 3 (IGFBP3) DMQVC3E MT DTT DMQVC3E MA Inhibitor DMQVC3E RN Salvianolic acid B improves myocardial function in diabetic cardiomyopathy by suppressing IGFBP3. J Mol Cell Cardiol. 2020 Feb;139:98-112. DMQVC3E RU https://pubmed.ncbi.nlm.nih.gov/31982427 DM0298B DI DM0298B DM0298B DN Salvicine DM0298B MI TT0IHXV DM0298B MN DNA topoisomerase II (TOP2) DM0298B MT DTT DM0298B MA Modulator DM0298B RN Salvicine, a novel topoisomerase II inhibitor, exerts its potent anticancer activity by ROS generation. Acta Pharmacol Sin. 2007 Sep;28(9):1460-5. DM0298B RU https://pubmed.ncbi.nlm.nih.gov/17723179 DMHVJZ6 DI DMHVJZ6 DMHVJZ6 DN SAM-531 DMHVJZ6 MI TTJS8PY DMHVJZ6 MN 5-HT 6 receptor (HTR6) DMHVJZ6 MT DTT DMHVJZ6 MA Antagonist DMHVJZ6 RN Activation of 5-HT6 receptors modulates sleep-wake activity and hippocampal theta oscillation. ACS Chem Neurosci. 2013 Jan 16;4(1):191-9. DMHVJZ6 RU https://pubmed.ncbi.nlm.nih.gov/23336058 DMXTOVE DI DMXTOVE DMXTOVE DN Sampatrilat DMXTOVE MI TT5TKPM DMXTOVE MN Neutral endopeptidase (MME) DMXTOVE MT DTT DMXTOVE MA Modulator DMXTOVE RN Sustained antihypertensive actions of a dual angiotensin-converting enzyme neutral endopeptidase inhibitor, sampatrilat, in black hypertensive subjects. Am J Hypertens. 1999 Jun;12(6):563-71. DMXTOVE RU https://pubmed.ncbi.nlm.nih.gov/10371365 DMP5Z9N DI DMP5Z9N DMP5Z9N DN SAN-300 DMP5Z9N MI TTPERWV DMP5Z9N MN Integrin alpha-1 (VLA-1) DMP5Z9N MT DTT DMP5Z9N MA Antagonist DMP5Z9N RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMP5Z9N RU http://phrma-docs.phrma.org/files/dmfile/medicines-in-development-drug-list-autoimmune-diseases.pdf DMDMQW0 DI DMDMQW0 DMDMQW0 DN SAR-100842 DMDMQW0 MI TTE2YJR DMDMQW0 MN Lysophosphatidate-3 receptor (LPAR3) DMDMQW0 MT DTT DMDMQW0 MA Modulator DMDMQW0 RN Promising Pharmacological Directions in the World of Lysophosphatidic Acid Signaling. Biomol Ther (Seoul) 2015 January; 23(1): 1-11. DMDMQW0 RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4286743/ DMDMQW0 DI DMDMQW0 DMDMQW0 DN SAR-100842 DMDMQW0 MI TTQ6S1K DMDMQW0 MN Lysophosphatidic acid receptor 1 (LPAR1) DMDMQW0 MT DTT DMDMQW0 MA Modulator DMDMQW0 RN Promising Pharmacological Directions in the World of Lysophosphatidic Acid Signaling. Biomol Ther (Seoul) 2015 January; 23(1): 1-11. DMDMQW0 RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4286743/ DMCLEXM DI DMCLEXM DMCLEXM DN SAR-110894 DMCLEXM MI TT9JNIC DMCLEXM MN Histamine H3 receptor (H3R) DMCLEXM MT DTT DMCLEXM MA Antagonist DMCLEXM RN SAR110894, a potent histamine H receptor antagonist, displays procognitive effects in rodents. Pharmacol Biochem Behav. 2012 Aug;102(2):203-14. DMCLEXM RU https://pubmed.ncbi.nlm.nih.gov/22542742 DMMCA9V DI DMMCA9V DMMCA9V DN SAR-113945 DMMCA9V MI TTJ3E9X DMMCA9V MN Inhibitor of nuclear factor kappa-B kinase beta (IKKB) DMMCA9V MT DTT DMMCA9V MA Inhibitor DMMCA9V RN The NF B pathway: a therapeutic target in glioblastoma. Oncotarget. 2011 August; 2(8): 646-653. DMMCA9V RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3248209/ DMJ34G6 DI DMJ34G6 DMJ34G6 DN SAR-125844 DMJ34G6 MI TTNDSF4 DMJ34G6 MN Proto-oncogene c-Met (MET) DMJ34G6 MT DTT DMJ34G6 MA Inhibitor DMJ34G6 RN The selective intravenous inhibitor of the MET tyrosine kinase SAR125844 inhibits tumor growth in MET-amplified cancer. Mol Cancer Ther. 2015 Feb;14(2):384-94. DMJ34G6 RU https://pubmed.ncbi.nlm.nih.gov/25504634 DMUICJD DI DMUICJD DMUICJD DN SAR-156597 DMUICJD MI TTDWHC3 DMUICJD MN Interleukin 4 receptor alpha (IL4R) DMUICJD MT DTT DMUICJD RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1697). DMUICJD RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1697 DMUICJD DI DMUICJD DMUICJD DN SAR-156597 DMUICJD MI TT0GVCH DMUICJD MN Interleukin-13 (IL13) DMUICJD MT DTT DMUICJD MA Modulator DMUICJD RN Bispecific antibodies rise again. Nat Rev Drug Discov. 2014 Nov;13(11):799-801. DMUICJD RU https://www.ncbi.nlm.nih.gov/pubmed/25359367 DMUICJD DI DMUICJD DMUICJD DN SAR-156597 DMUICJD MI TTLGTKB DMUICJD MN Interleukin-4 (IL4) DMUICJD MT DTT DMUICJD MA Modulator DMUICJD RN Bispecific antibodies rise again. Nat Rev Drug Discov. 2014 Nov;13(11):799-801. DMUICJD RU https://www.ncbi.nlm.nih.gov/pubmed/25359367 DMQM7IL DI DMQM7IL DMQM7IL DN SAR245409 DMQM7IL MI TTHBTOP DMQM7IL MN PI3-kinase gamma (PIK3CG) DMQM7IL MT DTT DMQM7IL MA Inhibitor DMQM7IL RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2156). DMQM7IL RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2156 DMQM7IL DI DMQM7IL DMQM7IL DN SAR245409 DMQM7IL MI TTCJG29 DMQM7IL MN Serine/threonine-protein kinase mTOR (mTOR) DMQM7IL MT DTT DMQM7IL MA Inhibitor DMQM7IL RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2109). DMQM7IL RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2109 DMBJU2G DI DMBJU2G DMBJU2G DN SAR-260093 DMBJU2G MI TT7QNVC DMBJU2G MN Glucose-dependent insulinotropic receptor (GPR119) DMBJU2G MT DTT DMBJU2G MA Agonist DMBJU2G RN GPR119 agonists for the treatment of type 2 diabetes. Expert Opin Ther Pat. 2009 Oct;19(10):1339-59. DMBJU2G RU https://pubmed.ncbi.nlm.nih.gov/19780700 DMEGNHZ DI DMEGNHZ DMEGNHZ DN SAR279356 DMEGNHZ MI TTAFD3Y DMEGNHZ MN Poly-N-acetyl glucosamine (PNAG) DMEGNHZ MT DTT DMEGNHZ MA Modulator DMEGNHZ RN Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41. DMEGNHZ RU https://www.ncbi.nlm.nih.gov/pubmed/15950434 DM63QY0 DI DM63QY0 DM63QY0 DN SAR292833 DM63QY0 MI TT946IA DM63QY0 MN Transient receptor potential cation channel V3 (TRPV3) DM63QY0 MT DTT DM63QY0 MA Modulator DM63QY0 RN Pharmacological profiling of the TRPV3 channel in recombinant and native assays. Br J Pharmacol. 2014 May;171(10):2631-44. DM63QY0 RU https://pubmed.ncbi.nlm.nih.gov/23848361 DMJ9RN8 DI DMJ9RN8 DMJ9RN8 DN SAR-339658 DMJ9RN8 MI TTMSB0A DMJ9RN8 MN Integrin alpha-2/beta-1 (ITGA2/B1) DMJ9RN8 MT DTT DMJ9RN8 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2578). DMJ9RN8 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2578 DMOSCBF DI DMOSCBF DMOSCBF DN SAR-3419 DMOSCBF MI TTW640A DMOSCBF MN B-lymphocyte surface antigen B4 (CD19) DMOSCBF MT DTT DMOSCBF RN A dose-escalation study of SAR3419, an anti-CD19 antibody maytansinoid conjugate, administered by intravenous infusion once weekly in patients with relapsed/refractory B-cell non-Hodgkin lymphoma. Clin Cancer Res. 2014 Jan 1;20(1):213-20. DMOSCBF RU https://pubmed.ncbi.nlm.nih.gov/24132920 DMS1YPZ DI DMS1YPZ DMS1YPZ DN SAR391786 DMS1YPZ MI TTSWPH8 DMS1YPZ MN Growth/differentiation factor 8 (GDF-8) DMS1YPZ MT DTT DMS1YPZ RN Myostatin (GDF-8) as a key factor linking muscle mass and bone structure. J Musculoskelet Neuronal Interact. 2010 Mar;10(1):56-63. DMS1YPZ RU https://pubmed.ncbi.nlm.nih.gov/20190380 DMF95KD DI DMF95KD DMF95KD DN SAR-407899 DMF95KD MI TTZN7RP DMF95KD MN Rho-associated protein kinase 1 (ROCK1) DMF95KD MT DTT DMF95KD MA Inhibitor DMF95KD RN The Rho kinase inhibitor SAR407899 potently inhibits endothelin-1-induced constriction of renal resistance arteries. J Hypertens. 2012 May;30(5):980-9. DMF95KD RU https://pubmed.ncbi.nlm.nih.gov/22388233 DM6Q295 DI DM6Q295 DM6Q295 DN SAR566658 DM6Q295 MI TTCFSPE DM6Q295 MN Carbonic anhydrase VI (CA-VI) DM6Q295 MT DTT DM6Q295 MA Inhibitor DM6Q295 RN An Antibody-Drug Conjugate Targeting MUC1-Associated Carbohydrate CA6 Shows Promising Antitumor Activities. Mol Cancer Ther. 2020 Aug;19(8):1660-1669. DM6Q295 RU https://pubmed.ncbi.nlm.nih.gov/32451330 DMT4FI5 DI DMT4FI5 DMT4FI5 DN SAR-566658 DMT4FI5 MI TTBHFYQ DMT4FI5 MN Mucin-1 (MUC1) DMT4FI5 MT DTT DMT4FI5 RN Integrating in vitro signaling and drug response data from single cell network profiling (SCNP) to inform on individual's AML biology.Molecular Cancer Therapeutics. 11/2011; 10(Supplement 1):A73-A73. DMT4FI5 RU http://mct.aacrjournals.org/content/12/11_Supplement/A73.short DMG9MN2 DI DMG9MN2 DMG9MN2 DN SAR97276 DMG9MN2 MI TTQ2GJ0 DMG9MN2 MN Plasmodial phospholipid metabolism (PPP metab) DMG9MN2 MT DTT DMG9MN2 MA Antagonist DMG9MN2 RN Transport and pharmacodynamics of albitiazolium, an antimalarial drug candidate. Br J Pharmacol. 2012 August; 166(8): 2263-2276. DMG9MN2 RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3437492/ DMBLHGP DI DMBLHGP DMBLHGP DN Saracatinib DMBLHGP MI TT6PKBN DMBLHGP MN Proto-oncogene c-Src (SRC) DMBLHGP MT DTT DMBLHGP MA Modulator DMBLHGP RN Novel dual Src/Abl inhibitors for hematologic and solid malignancies.Expert Opin Investig Drugs.2010 Aug;19(8):931-45. DMBLHGP RU https://www.ncbi.nlm.nih.gov/pubmed/20557276 DMBLHGP DI DMBLHGP DMBLHGP DN Saracatinib DMBLHGP MI TT3PJMV DMBLHGP MN Tyrosine-protein kinase ABL1 (ABL) DMBLHGP MT DTT DMBLHGP MA Modulator DMBLHGP RN Novel dual Src/Abl inhibitors for hematologic and solid malignancies.Expert Opin Investig Drugs.2010 Aug;19(8):931-45. DMBLHGP RU https://www.ncbi.nlm.nih.gov/pubmed/20557276 DMUE0AK DI DMUE0AK DMUE0AK DN Saratin DMUE0AK MI TTE5Q4N DMUE0AK MN VWF-dependent platelet-collagen conversion (VDDPCC) DMUE0AK MT DTT DMUE0AK MA Inhibitor DMUE0AK RN Antithrombotic effects of saratin on human atherosclerotic plaques. Thromb Haemost. 2004 Jul;92(1):191-200. DMUE0AK RU https://pubmed.ncbi.nlm.nih.gov/15213861 DM5R89X DI DM5R89X DM5R89X DN SARIPIDEM DM5R89X MI TTEX6LM DM5R89X MN GABA(A) receptor gamma-3 (GABRG3) DM5R89X MT DTT DM5R89X MA Modulator DM5R89X RN Behavioural effects of novel benzodiazepine (omega) receptor agonists and partial agonists: increases in punished responding and antagonism of the pentylenetetrazole cue. Behav Pharmacol. 1995 Mar;6(2):116-126. DM5R89X RU https://pubmed.ncbi.nlm.nih.gov/11224318 DM1M0PR DI DM1M0PR DM1M0PR DN Saruplase DM1M0PR MI TTGY7WI DM1M0PR MN Urokinase-type plasminogen activator (PLAU) DM1M0PR MT DTT DM1M0PR MA Activator DM1M0PR RN Pharmacokinetics and pharmacodynamics of saruplase, an unglycosylated single-chain urokinase-type plasminogen activator, in patients with acute myocardial infarction. Thromb Haemost. 1994 Nov;72(5):740-4. DM1M0PR RU https://pubmed.ncbi.nlm.nih.gov/7534946 DM27KFY DI DM27KFY DM27KFY DN SB-207266A DM27KFY MI TT07C3Y DM27KFY MN 5-HT 4 receptor (HTR4) DM27KFY MT DTT DM27KFY MA Antagonist DM27KFY RN Irritable bowel syndrome: new agents targeting serotonin receptor subtypes. Drugs. 2001;61(3):317-32. DM27KFY RU https://pubmed.ncbi.nlm.nih.gov/11293643 DM8TKG5 DI DM8TKG5 DM8TKG5 DN SB-265610 DM8TKG5 MI TT30C9G DM8TKG5 MN C-X-C chemokine receptor type 2 (CXCR2) DM8TKG5 MT DTT DM8TKG5 MA Antagonist DM8TKG5 RN Emerging drugs for the treatment of chronic obstructive pulmonary disease. Expert Opin Emerg Drugs. 2006 May;11(2):275-91. DM8TKG5 RU https://pubmed.ncbi.nlm.nih.gov/16634702 DM4NY58 DI DM4NY58 DM4NY58 DN SB-623 DM4NY58 MI TT6R7JZ DM4NY58 MN Histone deacetylase 1 (HDAC1) DM4NY58 MT DTT DM4NY58 MA Inhibitor DM4NY58 RN Histone deacetylase inhibitors in cancer therapy: latest developments, trends and medicinal chemistry perspective. Anticancer Agents Med Chem. 2007 Sep;7(5):576-92. DM4NY58 RU https://pubmed.ncbi.nlm.nih.gov/17896917 DMYLBOU DI DMYLBOU DMYLBOU DN SB-649868 DMYLBOU MI TT60Q8D DMYLBOU MN Orexin receptor type 1 (HCRTR1) DMYLBOU MT DTT DMYLBOU MA Antagonist DMYLBOU RN Clinical pipeline report, company report or official report of GlaxoSmithKline (2009). DMYLBOU RU http://www.gsk.com/investors/product_pipeline/docs/gsk-pipeline-feb09.pdf DMCY785 DI DMCY785 DMCY785 DN SB-656933 DMCY785 MI TT30C9G DMCY785 MN C-X-C chemokine receptor type 2 (CXCR2) DMCY785 MT DTT DMCY785 MA Antagonist DMCY785 RN Clinical pipeline report, company report or official report of GlaxoSmithKline (2009). DMCY785 RU http://www.gsk.com/investors/product_pipeline/docs/gsk-pipeline-feb09.pdf DMRYHWI DI DMRYHWI DMRYHWI DN SB-705498 DMRYHWI MI TTMI6F5 DMRYHWI MN Transient receptor potential cation channel V1 (TRPV1) DMRYHWI MT DTT DMRYHWI MA Blocker DMRYHWI RN Analgesic potential of TRPV1 antagonists. Biochem Pharmacol. 2009 Aug 1;78(3):211-6. DMRYHWI RU https://pubmed.ncbi.nlm.nih.gov/19481638 DMRWE5D DI DMRWE5D DMRWE5D DN SB-728-T DMRWE5D MI TT2CEJG DMRWE5D MN C-C chemokine receptor type 5 (CCR5) DMRWE5D MT DTT DMRWE5D MA Modulator DMRWE5D RN Gene Editing of CCR5 in Autologous CD4 T Cells of Persons Infected with HIV. N Engl J Med. 2014 March 6; 370(10): 901-910. DMRWE5D RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4084652/ DM6XJ9S DI DM6XJ9S DM6XJ9S DN SB-743921 DM6XJ9S MI TTTRP0H DM6XJ9S MN Kinesin-like protein KIF11 (KIF11) DM6XJ9S MT DTT DM6XJ9S MA Inhibitor DM6XJ9S RN Gateways to clinical trials. Methods Find Exp Clin Pharmacol. 2009 Jan-Feb;31(1):47-57. DM6XJ9S RU https://pubmed.ncbi.nlm.nih.gov/19357798 DMJRK6D DI DMJRK6D DMJRK6D DN SB-9200 DMJRK6D MI TTYPUHA DMJRK6D MN Pattern recognition receptor NOD2 (NOD2) DMJRK6D MT DTT DMJRK6D MA Modulator DMJRK6D RN Company reprot (Spring Bank Pharmaceuticals) (drug: SB 9200) DMJRK6D RU http://springbankpharm.com/spring-bank-pharmaceuticals-presents-preclinical-and-clinical-data-on-immunomodulatory-agent-sb-9200-at-the-2015-annual-meeting-of-the-european-association-for-the-study-of-the-liver/ DMJRK6D DI DMJRK6D DMJRK6D DN SB-9200 DMJRK6D MI TTVB0O3 DMJRK6D MN Retinoic acid-inducible gene-1 (RIG-1) DMJRK6D MT DTT DMJRK6D MA Modulator DMJRK6D RN Company reprot (Spring Bank Pharmaceuticals) (drug: SB 9200) DMJRK6D RU http://springbankpharm.com/spring-bank-pharmaceuticals-presents-preclinical-and-clinical-data-on-immunomodulatory-agent-sb-9200-at-the-2015-annual-meeting-of-the-european-association-for-the-study-of-the-liver/ DMG1VXR DI DMG1VXR DMG1VXR DN SBC-014 DMG1VXR MI TTC70AJ DMG1VXR MN Granulocyte colony-stimulating factor receptor (G-CSF-R) DMG1VXR MT DTT DMG1VXR MA Modulator DMG1VXR RN A glycosylated recombinant human granulocyte colony stimulating factor produced in a novel protein production system (AVI-014) in healthy subjects: a first-in human, single dose, controlled study. BMC Clin Pharmacol. 2009; 9: 2. DMG1VXR RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2639539/ DMSUQFJ DI DMSUQFJ DMSUQFJ DN SBI-087 DMSUQFJ MI TTUE541 DMSUQFJ MN Leukocyte surface antigen Leu-16 (CD20) DMSUQFJ MT DTT DMSUQFJ MA Inhibitor DMSUQFJ RN Translational Mini-Review Series on B Cell-Directed Therapies: Recent advances in B cell-directed biological therapies for autoimmune disorders. Clin Exp Immunol. 2009 August; 157(2): 198-208. DMSUQFJ RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2730845/ DMGH4Q0 DI DMGH4Q0 DMGH4Q0 DN SC-47085 DMGH4Q0 MI DEEHWOG DMGH4Q0 MN Azoreductase (azoR) DMGH4Q0 MT DME DMGH4Q0 MA Metabolism DMGH4Q0 RN Olsalazine. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic potential in inflammatory bowel disease. Drugs. 1991 Apr;41(4):647-64. DMGH4Q0 RU https://pubmed.ncbi.nlm.nih.gov/1711964 DM180VX DI DM180VX DM180VX DN SC-49483 DM180VX MI TTXWASR DM180VX MN Intestinal maltase-glucoamylase (MGAM) DM180VX MT DTT DM180VX MA Inhibitor DM180VX RN Pathology of perbutylated-N-butyl-1-deoxynojiromycin (an alpha-glucosidase-1 inhibitor) in Sprague-Dawley rats. Toxicol Pathol. 1996 Sep-Oct;24(5):531-8. DM180VX RU https://pubmed.ncbi.nlm.nih.gov/8923673 DM58HR7 DI DM58HR7 DM58HR7 DN SC-75416 DM58HR7 MI TTVKILB DM58HR7 MN Prostaglandin G/H synthase 2 (COX-2) DM58HR7 MT DTT DM58HR7 MA Inhibitor DM58HR7 RN Modeling and simulation to support dose selection and clinical development of SC-75416, a selective COX-2 inhibitor for the treatment of acute and ... Clin Pharmacol Ther. 2008 Jun;83(6):857-66. DM58HR7 RU https://pubmed.ncbi.nlm.nih.gov/17882158 DMMWCZS DI DMMWCZS DMMWCZS DN SCH 420814 DMMWCZS MI TTM2AOE DMMWCZS MN Adenosine A2a receptor (ADORA2A) DMMWCZS MT DTT DMMWCZS MA Antagonist DMMWCZS RN Novel pharmacological targets for the treatment of Parkinson's disease. Nat Rev Drug Discov. 2006 Oct;5(10):845-54. DMMWCZS RU https://pubmed.ncbi.nlm.nih.gov/17016425 DMPUAOE DI DMPUAOE DMPUAOE DN SCH-527123 DMPUAOE MI TTMWT8Z DMPUAOE MN C-X-C chemokine receptor type 1 (CXCR1) DMPUAOE MT DTT DMPUAOE MA Antagonist DMPUAOE RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMPUAOE RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DMPUAOE DI DMPUAOE DMPUAOE DN SCH-527123 DMPUAOE MI TT30C9G DMPUAOE MN C-X-C chemokine receptor type 2 (CXCR2) DMPUAOE MT DTT DMPUAOE MA Modulator DMPUAOE RN CXCR2 Antagonist MK-7123.A Phase 2 Proof-of-Concept Trial for Chronic Obstructive Pulmonary Disease.Am J Respir Crit Care Med.2015 May 1;191(9):1001-11. DMPUAOE RU https://www.ncbi.nlm.nih.gov/pubmed/25695403 DMPUAOE DI DMPUAOE DMPUAOE DN SCH-527123 DMPUAOE MI TTBD6I7 DMPUAOE MN Mucosal addressin cell adhesion molecule 1 (MADCAM1) DMPUAOE MT DTT DMPUAOE RN Emerging drugs to treat Crohn's disease. Expert Opin Emerg Drugs. 2007 Mar;12(1):49-59. DMPUAOE RU https://pubmed.ncbi.nlm.nih.gov/17355213 DMBJY1Z DI DMBJY1Z DMBJY1Z DN SCH-900271 DMBJY1Z MI TTWNV8U DMBJY1Z MN Nicotinic acid receptor (HCAR2) DMBJY1Z MT DTT DMBJY1Z MA Modulator DMBJY1Z RN Discovery of SCH 900271, a Potent Nicotinic Acid Receptor Agonist for the Treatment of Dyslipidemia. ACS Med Chem Lett. 2011 Nov 24;3(1):63-8. DMBJY1Z RU https://pubmed.ncbi.nlm.nih.gov/24900372 DM67EMK DI DM67EMK DM67EMK DN SCH-900776 DM67EMK MI TTTU902 DM67EMK MN Checkpoint kinase-1 (CHK1) DM67EMK MT DTT DM67EMK MA Inhibitor DM67EMK RN Targeting the replication checkpoint using SCH 900776, a potent and functionally selective CHK1 inhibitor identified via high content screening. Mol Cancer Ther. 2011 Apr;10(4):591-602. DM67EMK RU https://pubmed.ncbi.nlm.nih.gov/21321066 DMPBKUZ DI DMPBKUZ DMPBKUZ DN SCH-900978 DMPBKUZ MI TTZPO1L DMPBKUZ MN Substance-P receptor (TACR1) DMPBKUZ MT DTT DMPBKUZ MA Antagonist DMPBKUZ RN Clinical pipeline report, company report or official report of OPKO Health, Inc. DMPBKUZ RU http://investor.opko.com/secfiling.cfm?filingID=950123-10-54487&CIK=944809 DM1C9NQ DI DM1C9NQ DM1C9NQ DN SCY-635 DM1C9NQ MI TTATDGJ DM1C9NQ MN Calcium signal-modulating cyclophilin ligand (CAML) DM1C9NQ MT DTT DM1C9NQ MA Modulator DM1C9NQ RN SCY-635, a novel nonimmunosuppressive analog of cyclosporine that exhibits potent inhibition of hepatitis C virus RNA replication in vitro. Antimicrob Agents Chemother. 2010 Feb;54(2):660-72. DM1C9NQ RU https://pubmed.ncbi.nlm.nih.gov/19933795 DM80HOV DI DM80HOV DM80HOV DN SDF-1 DM80HOV MI TT4UGTF DM80HOV MN Stromal cell-derived factor 1 (CXCL12) DM80HOV MT DTT DM80HOV MA Inhibitor DM80HOV RN SDF-1 in myocardial repair. Gene Ther. 2012 Jun;19(6):583-7. DM80HOV RU https://pubmed.ncbi.nlm.nih.gov/22673496 DMPZ67G DI DMPZ67G DMPZ67G DN SDZ-281-240 DMPZ67G MI TTMW94E DMPZ67G MN FK506-binding protein 1A (FKBP1A) DMPZ67G MT DTT DMPZ67G MA Modulator DMPZ67G RN Clearing of psoriasis by a novel immunosuppressive macrolide. J Invest Dermatol. 1996 Apr;106(4):701-10. DMPZ67G RU https://pubmed.ncbi.nlm.nih.gov/8618008 DM2YIOE DI DM2YIOE DM2YIOE DN SDZ-MAR-327 DM2YIOE MI TTSQIFT DM2YIOE MN 5-HT 1A receptor (HTR1A) DM2YIOE MT DTT DM2YIOE MA Modulator DM2YIOE RN DOI: 10.1038/sj.mp.4002062 DM2YIOE RU http://www.nature.com/mp/journal/v12/n10/fig_tab/4002062t1.html DM2YIOE DI DM2YIOE DM2YIOE DN SDZ-MAR-327 DM2YIOE MI TTEX248 DM2YIOE MN Dopamine D2 receptor (D2R) DM2YIOE MT DTT DM2YIOE MA Modulator DM2YIOE RN DOI: 10.1038/sj.mp.4002062 DM2YIOE RU http://www.nature.com/mp/journal/v12/n10/fig_tab/4002062t1.html DMTQ2K0 DI DMTQ2K0 DMTQ2K0 DN SelG1 DMTQ2K0 MI TTE5VG0 DMTQ2K0 MN P-selectin (SELP) DMTQ2K0 MT DTT DMTQ2K0 RN Clinical pipeline report, company report or official report of Selexys Pharmaceuticals (2011). DMTQ2K0 RU http://www.selexys.com/product_pipeline.asp DMST4OR DI DMST4OR DMST4OR DN Selgantolimod DMST4OR MI TT8CWFK DMST4OR MN Toll-like receptor 8 (TLR8) DMST4OR MT DTT DMST4OR MA Agonist DMST4OR RN Discovery of GS-9688 (Selgantolimod) as a Potent and Selective Oral Toll-Like Receptor 8 Agonist for the Treatment of Chronic Hepatitis B. J Med Chem. 2020 Sep 24;63(18):10188-10203. DMST4OR RU https://pubmed.ncbi.nlm.nih.gov/32407112 DMDLOBZ DI DMDLOBZ DMDLOBZ DN Selinexor oral DMDLOBZ MI TTCJUR4 DMDLOBZ MN Exportin-1 (XPO1) DMDLOBZ MT DTT DMDLOBZ MA Inhibitor DMDLOBZ RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMDLOBZ RU http://phrma-docs.phrma.org/files/dmfile/MID_Neurological-Disorders-Drug-List_2018.pdf DMQM3IX DI DMQM3IX DMQM3IX DN SELODENOSON DMQM3IX MI TTK25J1 DMQM3IX MN Adenosine A1 receptor (ADORA1) DMQM3IX MT DTT DMQM3IX MA Agonist DMQM3IX RN Recent developments in adenosine receptor ligands and their potential as novel drugs. Biochim Biophys Acta. 2011 May;1808(5):1290-308. DMQM3IX RU https://pubmed.ncbi.nlm.nih.gov/21185259 DMJH6EL DI DMJH6EL DMJH6EL DN Selurampanel DMJH6EL MI TTAN6JD DMJH6EL MN Glutamate receptor AMPA (GRIA) DMJH6EL MT DTT DMJH6EL MA Antagonist DMJH6EL RN BGG492 (selurampanel), an AMPA/kainate receptor antagonist drug for epilepsy. Expert Opin Investig Drugs. 2014 Jan;23(1):107-13. DMJH6EL RU https://pubmed.ncbi.nlm.nih.gov/24147649 DMIJNLG DI DMIJNLG DMIJNLG DN Semapimod DMIJNLG MI TTB18GJ DMIJNLG MN Proto-oncogene c-RAF (c-RAF) DMIJNLG MT DTT DMIJNLG MA Modulator DMIJNLG RN Specific inhibition of c-Raf activity by semapimod induces clinical remission in severe Crohn's disease. J Immunol. 2005 Aug 15;175(4):2293-300. DMIJNLG RU https://pubmed.ncbi.nlm.nih.gov/16081798 DMLDBQ5 DI DMLDBQ5 DMLDBQ5 DN SEN-196 DMLDBQ5 MI TTUF2HO DMLDBQ5 MN NAD-dependent deacetylase sirtuin-1 (SIRT1) DMLDBQ5 MT DTT DMLDBQ5 MA Inhibitor DMLDBQ5 RN Sirtuin 1 (SIRT1): the misunderstood HDAC. J Biomol Screen. 2011 Dec;16(10):1153-69. DMLDBQ5 RU https://pubmed.ncbi.nlm.nih.gov/22086720 DMOH8LD DI DMOH8LD DMOH8LD DN Senktide DMOH8LD MI TT4BT06 DMOH8LD MN Integrin alpha-4 (ITGA4) DMOH8LD MT DTT DMOH8LD MA Inhibitor DMOH8LD RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMOH8LD RU http://phrma-docs.phrma.org/files/dmfile/2018_Heart-Disease-and-Stroke_MID-Drug-List.pdf DMOH8LD DI DMOH8LD DMOH8LD DN Senktide DMOH8LD MI TTBPGLU DMOH8LD MN Neuromedin-K receptor (TACR3) DMOH8LD MT DTT DMOH8LD MA Agonist DMOH8LD RN Implication of nigral tachykinin NK3 receptors in the maintenance of hypertension in spontaneously hypertensive rats: a pharmacologic and autoradiographic study. Br J Pharmacol. 2003 Feb;138(4):554-63. DMOH8LD RU https://pubmed.ncbi.nlm.nih.gov/12598409 DMA12HB DI DMA12HB DMA12HB DN SEP--4199 DMA12HB MI TT85JO3 DMA12HB MN 5-HT receptor (5HTR) DMA12HB MT DTT DMA12HB MA Antagonist DMA12HB RN ClinicalTrials.gov (NCT03543410) A Clinical Study to Test the Effectiveness of an Investigational Drug to Treat People That Have Major Depressive Episodes When They Have Bipolar 1 Depression. U.S. National Institutes of Health. DMA12HB RU https://clinicaltrials.gov/ct2/show/NCT03543410 DMA12HB DI DMA12HB DMA12HB DN SEP--4199 DMA12HB MI TTEX248 DMA12HB MN Dopamine D2 receptor (D2R) DMA12HB MT DTT DMA12HB MA Antagonist DMA12HB RN ClinicalTrials.gov (NCT03543410) A Clinical Study to Test the Effectiveness of an Investigational Drug to Treat People That Have Major Depressive Episodes When They Have Bipolar 1 Depression. U.S. National Institutes of Health. DMA12HB RU https://clinicaltrials.gov/ct2/show/NCT03543410 DMD8RU0 DI DMD8RU0 DMD8RU0 DN SEphB4-HSA DMD8RU0 MI TTKPV6O DMD8RU0 MN Ephrin type-B receptor 2 (EPHB2) DMD8RU0 MT DTT DMD8RU0 MA Inhibitor DMD8RU0 RN National Cancer Institute Drug Dictionary (drug name SEphB4-HSA). DMD8RU0 RU https://www.cancer.gov/publications/dictionaries/cancer-drug/def/recombinant-ephb4-hsa-fusion-protein DMDW5ZC DI DMDW5ZC DMDW5ZC DN SER-100 DMDW5ZC MI TTNT7K8 DMDW5ZC MN Nociceptin receptor (OPRL1) DMDW5ZC MT DTT DMDW5ZC MA Agonist DMDW5ZC RN Clinical pipeline report, company report or official report of Serodus ASA. DMDW5ZC RU http://www.serodus.com/Pipeline/SER100TRISH DMYT470 DI DMYT470 DMYT470 DN Seribantumab DMYT470 MI TTDC8N2 DMYT470 MN Erbb3 tyrosine kinase receptor (Erbb-3) DMYT470 MT DTT DMYT470 MA Antagonist DMYT470 RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMYT470 RU http://phrma-docs.phrma.org/files/dmfile/MID_Immuno-Oncology-2017_Drug-List1.pdf DMTNDM2 DI DMTNDM2 DMTNDM2 DN Setrobuvir DMTNDM2 MI TTMVBWH DMTNDM2 MN Hepatitis C virus RNA-directed RNA polymerase (HCV NS5B) DMTNDM2 MT DTT DMTNDM2 MA Inhibitor DMTNDM2 RN Clinical pipeline report, company report or official report of Anadys Pharmaceuticals (2011). DMTNDM2 RU http://www.anadyspharma.com/ DM9IMEZ DI DM9IMEZ DM9IMEZ DN Seviteronel DM9IMEZ MI TTRA5BZ DM9IMEZ MN Steroid 17-alpha-monooxygenase (S17AH) DM9IMEZ MT DTT DM9IMEZ MA Inhibitor DM9IMEZ RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DM9IMEZ RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DML10K3 DI DML10K3 DML10K3 DN SF1126 DML10K3 MI TTHBTOP DML10K3 MN PI3-kinase gamma (PIK3CG) DML10K3 MT DTT DML10K3 MA Modulator DML10K3 RN An integrin-targeted, pan-isoform, phosphoinositide-3 kinase inhibitor, SF1126, has activity against multiple myeloma in vivo.Cancer Chemother Pharmacol.2013 Apr;71(4):867-81. DML10K3 RU https://www.ncbi.nlm.nih.gov/pubmed/23355037 DML10K3 DI DML10K3 DML10K3 DN SF1126 DML10K3 MI TTCJG29 DML10K3 MN Serine/threonine-protein kinase mTOR (mTOR) DML10K3 MT DTT DML10K3 MA Inhibitor DML10K3 RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DML10K3 RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DMVIWNK DI DMVIWNK DMVIWNK DN SFV IL-12 gene therapy DMVIWNK MI TTGW72V DMVIWNK MN Interleukin-12 beta (IL12B) DMVIWNK MT DTT DMVIWNK MA Modulator DMVIWNK RN Clinical pipeline report, company report or official report of Trademarkia. DMVIWNK RU http://www.trademarkia.com/lipovil-12-79009798.html DMAQW9M DI DMAQW9M DMAQW9M DN SFX-01 DMAQW9M MI TTA6ZN2 DMAQW9M MN Nuclear factor erythroid 2-related factor 2 (Nrf2) DMAQW9M MT DTT DMAQW9M MA Activator DMAQW9M RN Therapeutic targeting of the NRF2 and KEAP1 partnership in chronic diseases. Nat Rev Drug Discov. 2019 Apr;18(4):295-317. DMAQW9M RU https://pubmed.ncbi.nlm.nih.gov/30610225 DMJ9M5D DI DMJ9M5D DMJ9M5D DN SGN-30 DMJ9M5D MI TT2GM5R DMJ9M5D MN Lymphocyte activation antigen CD30 (TNFRSF8) DMJ9M5D MT DTT DMJ9M5D RN The anti-CD30 monoclonal antibody SGN-30 promotes growth arrest and DNA fragmentation in vitro and affects antitumor activity in models of Hodgkin's disease. Cancer Res. 2002 Jul 1;62(13):3736-42. DMJ9M5D RU https://pubmed.ncbi.nlm.nih.gov/12097283 DMA4LNE DI DMA4LNE DMA4LNE DN SGN-LIV1A DMA4LNE MI TTZN1CF DMA4LNE MN Solute carrier family 39 member 6 (SLC39A6) DMA4LNE MT DTT DMA4LNE RN SGN-LIV1A: a novel antibody-drug conjugate targeting LIV-1 for the treatment of metastatic breast cancer. Mol Cancer Ther. 2014 Dec;13(12):2991-3000. DMA4LNE RU https://pubmed.ncbi.nlm.nih.gov/25253783 DM5XYFH DI DM5XYFH DM5XYFH DN SGS742 DM5XYFH MI TTDCVZW DM5XYFH MN Gamma-aminobutyric acid B receptor (GABBR) DM5XYFH MT DTT DM5XYFH MA Modulator DM5XYFH RN SGS742: the first GABA(B) receptor antagonist in clinical trials. Biochem Pharmacol. 2004 Oct 15;68(8):1479-87. DM5XYFH RU https://pubmed.ncbi.nlm.nih.gov/15451390 DMLYIPA DI DMLYIPA DMLYIPA DN SGT-53 DMLYIPA MI TT7SBF5 DMLYIPA MN Cellular tumor antigen p53 (TP53) DMLYIPA MT DTT DMLYIPA MA Stimulator DMLYIPA RN Transferrin receptor targeting nanomedicine delivering wild-type p53 gene sensitizes pancreatic cancer to gemcitabine therapy. Cancer Gene Ther. 2013 Apr;20(4):222-8. DMLYIPA RU https://pubmed.ncbi.nlm.nih.gov/23470564 DMGIRM1 DI DMGIRM1 DMGIRM1 DN SH-529 DMGIRM1 MI TT470F3 DMGIRM1 MN TNF alpha production (TNFA produ) DMGIRM1 MT DTT DMGIRM1 MA Modulator DMGIRM1 RN Particulate beta-glucan induces TNF-alpha production in wound macrophages via a redox-sensitive NF- beta-dependent pathway. Wound Repair Regen. 2011 May-Jun;19(3):411-9. DMGIRM1 RU https://pubmed.ncbi.nlm.nih.gov/21518092 DMIQB13 DI DMIQB13 DMIQB13 DN SHAPE DMIQB13 MI TTBH0VX DMIQB13 MN Histone deacetylase (HDAC) DMIQB13 MT DTT DMIQB13 MA Inhibitor DMIQB13 RN Clinical pipeline report, company report or official report of Tetralogic pharmaceuticals. DMIQB13 RU http://tetralogicpharma.com/shape/ DMT4UC1 DI DMT4UC1 DMT4UC1 DN Sibrotuzumab DMT4UC1 MI TTGPQ0F DMT4UC1 MN Prolyl endopeptidase FAP (FAP) DMT4UC1 MT DTT DMT4UC1 MA Inhibitor DMT4UC1 RN A Phase I dose-escalation study of sibrotuzumab in patients with advanced or metastatic fibroblast activation protein-positive cancer. Clin Cancer Res. 2003 May;9(5):1639-47. DMT4UC1 RU https://pubmed.ncbi.nlm.nih.gov/12738716 DM39RXO DI DM39RXO DM39RXO DN SiG12D-LODER DM39RXO MI TT9TVNM DM39RXO MN KRAS G12D mutant messenger RNA (KRAS mRNA) DM39RXO MT DTT DM39RXO MA Inhibitor DM39RXO RN Clinical pipeline report, company report or official report of Silenseed. DM39RXO RU https://www.silenseed.com/kras-loder-for-pancreatic-cancer/ DM75RFJ DI DM75RFJ DM75RFJ DN Siplizumab DM75RFJ MI TTJDUNO DM75RFJ MN T-cell surface antigen CD2 (CD2) DM75RFJ MT DTT DM75RFJ RN Emerging drugs for moderate-to-severe psoriasis. Expert Opin Emerg Drugs. 2005 Feb;10(1):35-52. DM75RFJ RU https://pubmed.ncbi.nlm.nih.gov/15757402 DMTXHJ9 DI DMTXHJ9 DMTXHJ9 DN Sirolimus DMTXHJ9 MI TT7HQAF DMTXHJ9 MN HUMAN mammalian target of rapamycin (mTOR) DMTXHJ9 MT DTT DMTXHJ9 MA Inhibitor DMTXHJ9 RN Network-based drug repurposing for novel coronavirus 2019-nCoV/SARS-CoV-2. Cell Discov. 2020 Mar 16;6:14. DMTXHJ9 RU https://pubmed.ncbi.nlm.nih.gov/32194980 DM90DTM DI DM90DTM DM90DTM DN Sirukumab DM90DTM MI TTJH4Y5 DM90DTM MN HUMAN interleukin 6 (IL6) DM90DTM MT DTT DM90DTM MA Inhibitor DM90DTM RN Sirukumab: A Potential Treatment for Mood Disorders Adv Ther. 2017 Jan;34(1):78-90. DM90DTM RU https://pubmed.ncbi.nlm.nih.gov/27913990 DMA9VGW DI DMA9VGW DMA9VGW DN Sitafloxacin DMA9VGW MI TTN6J5F DMA9VGW MN Bacterial DNA gyrase (Bact gyrase) DMA9VGW MT DTT DMA9VGW MA Inhibitor DMA9VGW RN Dual-targeting properties of the 3-aminopyrrolidyl quinolones, DC-159a and sitafloxacin, against DNA gyrase and topoisomerase IV: contribution to reducing in vitro emergence of quinolone-resistant Streptococcus pneumoniae. J Antimicrob Chemother. 2008 Jul;62(1):98-104. DMA9VGW RU https://pubmed.ncbi.nlm.nih.gov/18390884 DMA9VGW DI DMA9VGW DMA9VGW DN Sitafloxacin DMA9VGW MI TTFK8YB DMA9VGW MN Bacterial DNA topoisomerase 4A (Bact parC) DMA9VGW MT DTT DMA9VGW MA Inhibitor DMA9VGW RN Dual-targeting properties of the 3-aminopyrrolidyl quinolones, DC-159a and sitafloxacin, against DNA gyrase and topoisomerase IV: contribution to reducing in vitro emergence of quinolone-resistant Streptococcus pneumoniae. J Antimicrob Chemother. 2008 Jul;62(1):98-104. DMA9VGW RU https://pubmed.ncbi.nlm.nih.gov/18390884 DMY3JWO DI DMY3JWO DMY3JWO DN Sitamaquine DMY3JWO MI DECB0K3 DMY3JWO MN Cytochrome P450 2D6 (CYP2D6) DMY3JWO MT DME DMY3JWO MA Metabolism DMY3JWO RN Differential cytochrome P450 2D metabolism alters tafenoquine pharmacokinetics. Antimicrob Agents Chemother. 2015 Jul;59(7):3864-9. DMY3JWO RU https://www.ncbi.nlm.nih.gov/pubmed/?term=25870069 DMNRHMX DI DMNRHMX DMNRHMX DN SKF-110679 DMNRHMX MI TTKMAZ6 DMNRHMX MN Growth hormone receptor (GHR) DMNRHMX MT DTT DMNRHMX MA Modulator DMNRHMX RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1093). DMNRHMX RU http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=1093 DMRHD6B DI DMRHD6B DMRHD6B DN SKL-NP DMRHD6B MI TTKLW9S DMRHD6B MN Hyperpolarization cyclic nucleotide-gated channel (HCN) DMRHD6B MT DTT DMRHD6B MA Modulator DMRHD6B RN A Novel Carbamoyloxy Arylalkanoyl Arylpiperazine Compound (SKL-NP) Inhibits Hyperpolarization-Activated Cyclic Nucleotide-Gated (HCN) Channel Currents in Rat Dorsal Root Ganglion Neurons. Korean J Physiol Pharmacol. 2012 Aug;16(4):237-41. DMRHD6B RU https://pubmed.ncbi.nlm.nih.gov/22915988 DMCDON3 DI DMCDON3 DMCDON3 DN SLV 306 DMCDON3 MI TT1BGDH DMCDON3 MN Endothelin-converting enzyme (ECE) DMCDON3 MT DTT DMCDON3 MA Modulator DMCDON3 RN The dual endothelin converting enzyme/neutral endopeptidase inhibitor SLV-306 (daglutril), inhibits systemic conversion of big endothelin-1 in humans. Life Sci. 2012 Oct 15;91(13-14):743-8. DMCDON3 RU https://pubmed.ncbi.nlm.nih.gov/22480515 DMCDON3 DI DMCDON3 DMCDON3 DN SLV 306 DMCDON3 MI TT5TKPM DMCDON3 MN Neutral endopeptidase (MME) DMCDON3 MT DTT DMCDON3 MA Modulator DMCDON3 RN The dual endothelin converting enzyme/neutral endopeptidase inhibitor SLV-306 (daglutril), inhibits systemic conversion of big endothelin-1 in humans. Life Sci. 2012 Oct 15;91(13-14):743-8. DMCDON3 RU https://pubmed.ncbi.nlm.nih.gov/22480515 DM867BJ DI DM867BJ DM867BJ DN SLV320 DM867BJ MI TTK25J1 DM867BJ MN Adenosine A1 receptor (ADORA1) DM867BJ MT DTT DM867BJ MA Antagonist DM867BJ RN Role of matrix metalloproteinases and their tissue inhibitors as potential biomarkers of left ventricular remodelling in the athlete's heart. Clin Sci (Lond). 2009 Jul 16;117(4):157-64. DM867BJ RU https://pubmed.ncbi.nlm.nih.gov/19196241 DMXCJKY DI DMXCJKY DMXCJKY DN SLV-334 DMXCJKY MI TT1BGDH DMXCJKY MN Endothelin-converting enzyme (ECE) DMXCJKY MT DTT DMXCJKY MA Modulator DMXCJKY RN Clinical trials in traumatic brain injury: past experience and current developments.Neurotherapeutics.2010 Jan;7(1):115-26. DMXCJKY RU https://www.ncbi.nlm.nih.gov/pubmed/20129503 DMXCJKY DI DMXCJKY DMXCJKY DN SLV-334 DMXCJKY MI TT5TKPM DMXCJKY MN Neutral endopeptidase (MME) DMXCJKY MT DTT DMXCJKY MA Modulator DMXCJKY RN Clinical trials in traumatic brain injury: past experience and current developments.Neurotherapeutics.2010 Jan;7(1):115-26. DMXCJKY RU https://www.ncbi.nlm.nih.gov/pubmed/20129503 DMM3AI8 DI DMM3AI8 DMM3AI8 DN SLx-4090 DMM3AI8 MI TTUS1RD DMM3AI8 MN Microsomal triglyceride transfer protein (MTTP) DMM3AI8 MT DTT DMM3AI8 MA Modulator DMM3AI8 RN A small-molecule inhibitor of enterocytic microsomal triglyceride transfer protein, SLx-4090: biochemical, pharmacodynamic, pharmacokinetic, and safety profile. J Pharmacol Exp Ther. 2011 Jun;337(3):775-85. DMM3AI8 RU https://pubmed.ncbi.nlm.nih.gov/21406547 DMOLTAD DI DMOLTAD DMOLTAD DN SM-04690 DMOLTAD MI TTFPSHI DMOLTAD MN Wnt signaling pathway (Wnt pathway) DMOLTAD MT DTT DMOLTAD MA Modulator DMOLTAD RN Clinical pipeline report, company report or official report of Phrma.org Arthritis 2014. DMOLTAD RU http://www.phrma.org/sites/default/files/pdf/2014-meds-in-dev-arthritis.pdf DMTJOQX DI DMTJOQX DMTJOQX DN SMP-986 DMTJOQX MI TTOXS3C DMTJOQX MN Muscarinic acetylcholine receptor (CHRM) DMTJOQX MT DTT DMTJOQX MA Antagonist DMTJOQX RN DUAL INHIBITION OF Na+-CHANNEL AND MUSCARINIC RECEPTORS BY SMP-986 EFFICIENTLY IMPROVED VOIDING FUNCTION COMPARED TO ANTI-MUSCARINIC AGENTS IN TWO CONSCIOUS RAT MODELS OF DETRUSOR OVERACTIVITY. The Journal of Urology Volume 179, Issue 4, Supplement, April 2008, Pages 129. DMTJOQX RU http://www.sciencedirect.com/science/article/pii/S0022534708603717 DMTJOQX DI DMTJOQX DMTJOQX DN SMP-986 DMTJOQX MI TTRK8B9 DMTJOQX MN Sodium channel unspecific (NaC) DMTJOQX MT DTT DMTJOQX MA Antagonist DMTJOQX RN DUAL INHIBITION OF Na+-CHANNEL AND MUSCARINIC RECEPTORS BY SMP-986 EFFICIENTLY IMPROVED VOIDING FUNCTION COMPARED TO ANTI-MUSCARINIC AGENTS IN TWO CONSCIOUS RAT MODELS OF DETRUSOR OVERACTIVITY. The Journal of Urology Volume 179, Issue 4, Supplement, April 2008, Pages 129. DMTJOQX RU http://www.sciencedirect.com/science/article/pii/S0022534708603717 DMCD6G1 DI DMCD6G1 DMCD6G1 DN SMT-C1100 DMCD6G1 MI TTNO1VA DMCD6G1 MN Utrophin (UTRN) DMCD6G1 MT DTT DMCD6G1 MA Regulator (upregulator) DMCD6G1 RN Safety, tolerability, and pharmacokinetics of SMT C1100, a 2-arylbenzoxazole utrophin modulator, following single- and multiple-dose administration to healthy male adult volunteers. J Clin Pharmacol.2015 Jun;55(6):698-707. DMCD6G1 RU https://pubmed.ncbi.nlm.nih.gov/25651188 DMPN314 DI DMPN314 DMPN314 DN SNA-120 DMPN314 MI TTTDVOJ DMPN314 MN Tropomyosin-related kinase A (TrkA) DMPN314 MT DTT DMPN314 MA Inhibitor DMPN314 RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMPN314 RU http://phrma-docs.phrma.org/files/dmfile/MID_Skin_Diseases_2018_9_FINAL.pdf DMO4EYX DI DMO4EYX DMO4EYX DN Soblidotin DMO4EYX MI TTML2WA DMO4EYX MN Tubulin (TUB) DMO4EYX MT DTT DMO4EYX MA Modulator DMO4EYX RN Antitumor activity of TZT-1027 (Soblidotin). Anticancer Res. 2006 May-Jun;26(3A):1973-81. DMO4EYX RU https://pubmed.ncbi.nlm.nih.gov/16827132 DMKNIVG DI DMKNIVG DMKNIVG DN Sodium butyrate DMKNIVG MI TT6R7JZ DMKNIVG MN Histone deacetylase 1 (HDAC1) DMKNIVG MT DTT DMKNIVG MA Inhibitor DMKNIVG RN Anticancer activities of histone deacetylase inhibitors. Nat Rev Drug Discov. 2006 Sep;5(9):769-84. DMKNIVG RU https://pubmed.ncbi.nlm.nih.gov/16955068 DMH5MVE DI DMH5MVE DMH5MVE DN Sodium stibogluconate DMH5MVE MI TTNJKC3 DMH5MVE MN Leishmania DNA topoisomerase I (Leishm TOP1) DMH5MVE MT DTT DMH5MVE MA Modulator DMH5MVE RN Inhibition of Leishmania donovani promastigote DNA topoisomerase I and human monocyte DNA topoisomerases I and II by antimonial drugs and classical antitopoisomerase agents. J Parasitol. 2004 Oct;90(5):1155-62. DMH5MVE RU https://pubmed.ncbi.nlm.nih.gov/15562618 DM157U0 DI DM157U0 DM157U0 DN Sofinicline DM157U0 MI TTL1ATN DM157U0 MN Neuronal acetylcholine receptor alpha-4/beta-2 (CHRNA4/B2) DM157U0 MT DTT DM157U0 MA Modulator DM157U0 RN Sofinicline: a novel nicotinic acetylcholine receptor agonist in the treatment of attention-deficit/hyperactivity disorder. Expert Opin Investig Drugs. 2014 Aug;23(8):1157-63. DM157U0 RU https://pubmed.ncbi.nlm.nih.gov/24965900 DML2ZWR DI DML2ZWR DML2ZWR DN Solubilized type 1 native bovine collagen DML2ZWR MI TTUABC1 DML2ZWR MN Collagen I (COL1A2) DML2ZWR MT DTT DML2ZWR MA Modulator DML2ZWR RN Company report (Argentisrx) DML2ZWR RU http://www.argentisrx.com/arg201-development-to-date.html DMKCBSM DI DMKCBSM DMKCBSM DN SOM3355 DMKCBSM MI TTNZRI3 DMKCBSM MN Synaptic vesicle amine transporter (SLC18A2) DMKCBSM MT DTT DMKCBSM MA Inhibitor DMKCBSM RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMKCBSM RU http://phrma-docs.phrma.org/files/dmfile/MID_Neurological-Disorders-Drug-List_2018.pdf DMTVS3A DI DMTVS3A DMTVS3A DN Somatoprim DMTVS3A MI TTOMNR9 DMTVS3A MN Somatostatin receptor (SSTR) DMTVS3A MT DTT DMTVS3A MA Modulator DMTVS3A RN DG3173 (somatoprim), a unique somatostatin receptor subtypes 2-, 4- and 5-selective analogue, effectively reduces GH secretion in human GH-secreting pituitary adenomas even in Octreotide non-responsive tumours.Eur J Endocrinol.2012 Feb;166(2):223-34. DMTVS3A RU https://www.ncbi.nlm.nih.gov/pubmed/22065857 DMK3RL8 DI DMK3RL8 DMK3RL8 DN Somatropin intranasal rhGH DMK3RL8 MI TTT3YKH DMK3RL8 MN Somatotropin (GH1) DMK3RL8 MT DTT DMK3RL8 MA Modulator DMK3RL8 RN Long-term efficacy and safety of somatropin for adult growth hormone deficiency.Treat Endocrinol.2003;2(2):109-20. DMK3RL8 RU https://www.ncbi.nlm.nih.gov/pubmed/15871547 DME53YS DI DME53YS DME53YS DN Sotrastaurin acetate DME53YS MI TTFJ8Q1 DME53YS MN Protein kinase C alpha (PRKCA) DME53YS MT DTT DME53YS MA Inhibitor DME53YS RN Emerging drugs for psoriasis. Expert Opin Emerg Drugs. 2009 Mar;14(1):145-63. DME53YS RU https://pubmed.ncbi.nlm.nih.gov/19249988 DME53YS DI DME53YS DME53YS DN Sotrastaurin acetate DME53YS MI TTYPXQF DME53YS MN Protein kinase C beta (PRKCB) DME53YS MT DTT DME53YS MA Inhibitor DME53YS RN Emerging drugs for psoriasis. Expert Opin Emerg Drugs. 2009 Mar;14(1):145-63. DME53YS RU https://pubmed.ncbi.nlm.nih.gov/19249988 DME53YS DI DME53YS DME53YS DN Sotrastaurin acetate DME53YS MI TT8QL1J DME53YS MN Protein kinase C theta (PRKCQ) DME53YS MT DTT DME53YS MA Inhibitor DME53YS RN Emerging drugs for psoriasis. Expert Opin Emerg Drugs. 2009 Mar;14(1):145-63. DME53YS RU https://pubmed.ncbi.nlm.nih.gov/19249988 DM2UKJV DI DM2UKJV DM2UKJV DN SP-333 DM2UKJV MI TTLDPRG DM2UKJV MN Guanylyl cyclase C (GUCY2C) DM2UKJV MT DTT DM2UKJV MA Agonist DM2UKJV RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DM2UKJV RU http://phrma-docs.phrma.org/files/dmfile/medicines-in-development-drug-list-autoimmune-diseases.pdf DM9OPK3 DI DM9OPK3 DM9OPK3 DN SPD-556 DM9OPK3 MI TTK8R02 DM9OPK3 MN Vasopressin V2 receptor (V2R) DM9OPK3 MT DTT DM9OPK3 MA Antagonist DM9OPK3 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 368). DM9OPK3 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=368 DMJH2AC DI DMJH2AC DMJH2AC DN SPD-557 DMJH2AC MI TT07C3Y DMJH2AC MN 5-HT 4 receptor (HTR4) DMJH2AC MT DTT DMJH2AC MA Agonist DMJH2AC RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 9). DMJH2AC RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=9 DMKJ9LU DI DMKJ9LU DMKJ9LU DN SPD602 DMKJ9LU MI TTUDR0C DMKJ9LU MN Iron (Fe) DMKJ9LU MT DTT DMKJ9LU MA Modulator DMKJ9LU RN ClinicalTrials.gov (NCT01604941) Pharmacokinetics of SSP-004184 in the Treatment of Chronic Iron Overload Requiring Chelation Therapy. U.S. National Institutes of Health. DMKJ9LU RU https://clinicaltrials.gov/ct2/show/NCT01604941 DM26AHR DI DM26AHR DM26AHR DN SPI-1005 DM26AHR MI TTNHMO8 DM26AHR MN COVID-19 papain-like proteinase (PL-PRO) DM26AHR MT DTT DM26AHR MA Inhibitor DM26AHR RN Structure of Mpro from COVID-19 virus and discovery of its inhibitors. Nature. 2020 Apr 9. DM26AHR RU https://pubmed.ncbi.nlm.nih.gov/32272481 DMNPRMC DI DMNPRMC DMNPRMC DN SPI-1620 DMNPRMC MI TT3ZTGU DMNPRMC MN Endothelin B receptor (EDNRB) DMNPRMC MT DTT DMNPRMC MA Agonist DMNPRMC RN Clinical pipeline report, company report or official report of Spectrum Phamaceuticals (2009). DMNPRMC RU http://www.spectrumpharm.com/products_Spectrum.html DMHC2AW DI DMHC2AW DMHC2AW DN SPI-205 DMHC2AW MI TTEDJN4 DMHC2AW MN Low-affinity nerve growth factor receptor (NGFR) DMHC2AW MT DTT DMHC2AW MA Modulator DMHC2AW RN AIT-082 NeoTherapeutics Inc. IDrugs. 1998 Oct;1(6):694-9. DMHC2AW RU https://www.ncbi.nlm.nih.gov/pubmed/18465624 DM7NJWY DI DM7NJWY DM7NJWY DN Spiroglumide DM7NJWY MI TTVBI8W DM7NJWY MN Dopamine transporter (DAT) DM7NJWY MT DTT DM7NJWY MA Inhibitor DM7NJWY RN Emerging drugs in neuropathic pain. Expert Opin Emerg Drugs. 2007 Mar;12(1):113-26. DM7NJWY RU https://pubmed.ncbi.nlm.nih.gov/17355217 DM7NJWY DI DM7NJWY DM7NJWY DN Spiroglumide DM7NJWY MI TTVFO0U DM7NJWY MN Gastrin/cholecystokinin type B receptor (CCKBR) DM7NJWY MT DTT DM7NJWY MA Antagonist DM7NJWY RN Effect of dexloxiglumide and spiroglumide, two new CCK-receptor antagonists, on gastric emptying and secretion in the rat: evaluation of their receptor selectivity in vivo. Aliment Pharmacol Ther. 1996 Jun;10(3):411-9. DM7NJWY RU https://pubmed.ncbi.nlm.nih.gov/8791971 DM7NJWY DI DM7NJWY DM7NJWY DN Spiroglumide DM7NJWY MI TTAWNKZ DM7NJWY MN Norepinephrine transporter (NET) DM7NJWY MT DTT DM7NJWY MA Inhibitor DM7NJWY RN Emerging drugs in neuropathic pain. Expert Opin Emerg Drugs. 2007 Mar;12(1):113-26. DM7NJWY RU https://pubmed.ncbi.nlm.nih.gov/17355217 DMRXCUQ DI DMRXCUQ DMRXCUQ DN SPL-108 DMRXCUQ MI TTWFBT7 DMRXCUQ MN Extracellular matrix receptor III (CD44) DMRXCUQ MT DTT DMRXCUQ MA Inhibitor DMRXCUQ RN Clinical pipeline report, company report or official report of Splash Pharmaceuticals. DMRXCUQ RU http://www.splashpharma.com/new-page DMZIC4Q DI DMZIC4Q DMZIC4Q DN SPN-812 DMZIC4Q MI TTAWNKZ DMZIC4Q MN Norepinephrine transporter (NET) DMZIC4Q MT DTT DMZIC4Q MA Inhibitor DMZIC4Q RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMZIC4Q RU http://phrma-docs.phrma.org/files/dmfile/MID_Mental-Illness-2017-Drug-List_Final.pdf DMOVQP8 DI DMOVQP8 DMOVQP8 DN SPP-600 DMOVQP8 MI TTB2MXP DMOVQP8 MN Angiotensinogenase renin (REN) DMOVQP8 MT DTT DMOVQP8 MA Inhibitor DMOVQP8 RN Effect of SPP 635, a renin inhibitor, on intraocular pressure in glaucomatous monkey eyes. Exp Eye Res. 2012 Jan;94(1):146-9. DMOVQP8 RU https://pubmed.ncbi.nlm.nih.gov/22173206 DMFAO5G DI DMFAO5G DMFAO5G DN S-PRAnt DMFAO5G MI TTUV8G9 DMFAO5G MN Progesterone receptor (PGR) DMFAO5G MT DTT DMFAO5G MA Antagonist DMFAO5G RN BAY 1002670: a novel, highly potent and selective progesterone receptor modulator for gynaecological therapies. Hum Reprod. 2013 Aug;28(8):2253-64. DMFAO5G RU https://pubmed.ncbi.nlm.nih.gov/23739217 DMWK9BX DI DMWK9BX DMWK9BX DN SQ-109 DMWK9BX MI DECB0K3 DMWK9BX MN Cytochrome P450 2D6 (CYP2D6) DMWK9BX MT DME DMWK9BX MA Metabolism DMWK9BX RN Interspecies pharmacokinetics and in vitro metabolism of SQ109. Br J Pharmacol. 2006 Mar;147(5):476-85. DMWK9BX RU https://www.ncbi.nlm.nih.gov/pubmed/?term=16432511 DMWK9BX DI DMWK9BX DMWK9BX DN SQ-109 DMWK9BX MI DEGTFWK DMWK9BX MN Mephenytoin 4-hydroxylase (CYP2C19) DMWK9BX MT DME DMWK9BX MA Metabolism DMWK9BX RN Interspecies pharmacokinetics and in vitro metabolism of SQ109. Br J Pharmacol. 2006 Mar;147(5):476-85. DMWK9BX RU https://www.ncbi.nlm.nih.gov/pubmed/?term=16432511 DMWK9BX DI DMWK9BX DMWK9BX DN SQ-109 DMWK9BX MI TTTLB3R DMWK9BX MN Mycobacterium Membrane protein mmpL3 (MycB mmpL3) DMWK9BX MT DTT DMWK9BX MA Modulator DMWK9BX RN SQ109 targets MmpL3, a membrane transporter of trehalose monomycolate involved in mycolic acid donation to the cell wall core of Mycobacterium tuberculosis. Antimicrob Agents Chemother. 2012 Apr;56(4):1797-809. DMWK9BX RU https://pubmed.ncbi.nlm.nih.gov/22252828 DMRFO34 DI DMRFO34 DMRFO34 DN SR 16234 DMRFO34 MI TTZAYWL DMRFO34 MN Estrogen receptor (ESR) DMRFO34 MT DTT DMRFO34 MA Modulator DMRFO34 RN National Cancer Institute Drug Dictionary (drug id 599816). DMRFO34 RU http://www.cancer.gov/publications/dictionaries/cancer-drug?cdrid=599816 DMNAECP DI DMNAECP DMNAECP DN SR-147778 DMNAECP MI TT6OEDT DMNAECP MN Cannabinoid receptor 1 (CB1) DMNAECP MT DTT DMNAECP MA Modulator DMNAECP RN Surinabant, a selective cannabinoid receptor type 1 antagonist, inhibits 9-tetrahydrocannabinol-induced central nervous system and heart rate effects in humans.Br J Clin Pharmacol.2013 Jul;76(1):65-77. DMNAECP RU https://www.ncbi.nlm.nih.gov/pubmed/23278647 DMFDA4Y DI DMFDA4Y DMFDA4Y DN SR-2640 DMFDA4Y MI TTTWGIX DMFDA4Y MN Leukotriene receptor (LTR) DMFDA4Y MT DTT DMFDA4Y MA Modulator DMFDA4Y RN Effect of the leukotriene LTD4/LTE4 antagonist, SR 2640, in ulcerative colitis: an open clinical study. Prostaglandins Leukot Essent Fatty Acids. 1991 Mar;42(3):181-4. DMFDA4Y RU https://pubmed.ncbi.nlm.nih.gov/1677467 DMQSN7B DI DMQSN7B DMQSN7B DN SR-31747 DMQSN7B MI TT4VQZX DMQSN7B MN Cholestenol delta-isomerase (EBP) DMQSN7B MT DTT DMQSN7B MA Modulator DMQSN7B RN Both the immunosuppressant SR31747 and the antiestrogen tamoxifen bind to an emopamil-insensitive site of mammalian Delta8-Delta7 sterol isomerase. J Pharmacol Exp Ther. 1998 Jun;285(3):1296-302. DMQSN7B RU https://pubmed.ncbi.nlm.nih.gov/9618436 DMTOCIV DI DMTOCIV DMTOCIV DN SR-43845 DMTOCIV MI TTB2MXP DMTOCIV MN Angiotensinogenase renin (REN) DMTOCIV MT DTT DMTOCIV MA Inhibitor DMTOCIV RN Effects of a renin inhibitor, SR 43845, and of captopril on blood pressure and plasma active renin in conscious sodium-replete macaca. J Hypertens Suppl. 1989 Apr;7(2):S33-5. DMTOCIV RU https://pubmed.ncbi.nlm.nih.gov/2666612 DMW6UA3 DI DMW6UA3 DMW6UA3 DN SR-46559A DMW6UA3 MI TTZ9SOR DMW6UA3 MN Muscarinic acetylcholine receptor M1 (CHRM1) DMW6UA3 MT DTT DMW6UA3 MA Agonist DMW6UA3 RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015 DMW6UA3 RU https://www.accessdata.fda.gov/scripts/cder/drugsatfda/ DM5GAC4 DI DM5GAC4 DM5GAC4 DN SRD-441 DM5GAC4 MI TTZBFA0 DM5GAC4 MN Protease unspecific (PRO) DM5GAC4 MT DTT DM5GAC4 MA Inhibitor DM5GAC4 RN Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800029807) DM5GAC4 RU http://adisinsight.springer.com/drugs/800029807 DMYAXNM DI DMYAXNM DMYAXNM DN SRK-015 DMYAXNM MI TTM8I2X DMYAXNM MN Myostatin (MSTN) DMYAXNM MT DTT DMYAXNM MA Inhibitor DMYAXNM RN Clinical pipeline report, company report or official report of Scholar Rock. DMYAXNM RU https://scholarrock.com/our-pipeline/spinal-muscular-atrophy/ DMR09IH DI DMR09IH DMR09IH DN SRP-9001 DMR09IH MI TT48MP6 DMR09IH MN Dystrophin (DMD) DMR09IH MT DTT DMR09IH MA Replacement DMR09IH RN Clinical pipeline report, company report or official report of Sarepta Therapeutics. DMR09IH RU https://www.sarepta.com/products-pipeline/pipeline DMKOTUJ DI DMKOTUJ DMKOTUJ DN SRX246 DMKOTUJ MI TT4TFGN DMKOTUJ MN Vasopressin V1a receptor (V1AR) DMKOTUJ MT DTT DMKOTUJ MA Antagonist DMKOTUJ RN Safety and Tolerability of SRX246, a Vasopressin 1a Antagonist, in Irritable Huntington's Disease Patients-A Randomized Phase 2 Clinical Trial. J Clin Med. 2020 Nov 16;9(11):3682. DMKOTUJ RU https://pubmed.ncbi.nlm.nih.gov/33207828 DMMU41F DI DMMU41F DMMU41F DN SRX-246 DMMU41F MI TT4TFGN DMMU41F MN Vasopressin V1a receptor (V1AR) DMMU41F MT DTT DMMU41F MA Antagonist DMMU41F RN Pharmacokinetics and metabolism of SRX246: a potent and selective vasopressin 1a antagonist. J Pharm Sci. 2013 Jun;102(6):2033-43. DMMU41F RU https://pubmed.ncbi.nlm.nih.gov/23471831 DMGJEB8 DI DMGJEB8 DMGJEB8 DN SSR125543 DMGJEB8 MI TT7EFHR DMGJEB8 MN Corticotropin-releasing factor receptor 1 (CRHR1) DMGJEB8 MT DTT DMGJEB8 MA Antagonist DMGJEB8 RN Pharma & Vaccines. Product Development Pipeline. April 29 2009. DMGJEB8 RU http://en.sanofi-aventis.com/binaries/RD_Phase_III_EN_tcm28-24007.pdf DMCMD93 DI DMCMD93 DMCMD93 DN SSR149415 DMCMD93 MI TTSCIUP DMCMD93 MN Oxytocin receptor (OTR) DMCMD93 MT DTT DMCMD93 MA Inhibitor DMCMD93 RN Tetrahydroquinoline sulfonamides as vasopressin 1b receptor antagonists. Bioorg Med Chem Lett. 2009 Nov 1;19(21):6018-22. DMCMD93 RU https://pubmed.ncbi.nlm.nih.gov/19800231 DMCMD93 DI DMCMD93 DMCMD93 DN SSR149415 DMCMD93 MI TT4TFGN DMCMD93 MN Vasopressin V1a receptor (V1AR) DMCMD93 MT DTT DMCMD93 MA Inhibitor DMCMD93 RN Tetrahydroquinoline sulfonamides as vasopressin 1b receptor antagonists. Bioorg Med Chem Lett. 2009 Nov 1;19(21):6018-22. DMCMD93 RU https://pubmed.ncbi.nlm.nih.gov/19800231 DMCMD93 DI DMCMD93 DMCMD93 DN SSR149415 DMCMD93 MI TTL9MHW DMCMD93 MN Vasopressin V1b receptor (V1BR) DMCMD93 MT DTT DMCMD93 MA Antagonist DMCMD93 RN Novel drugs and therapeutic targets for severe mood disorders. Neuropsychopharmacology. 2008 Aug;33(9):2080-92. DMCMD93 RU https://pubmed.ncbi.nlm.nih.gov/18172433 DMCMD93 DI DMCMD93 DMCMD93 DN SSR149415 DMCMD93 MI TTK8R02 DMCMD93 MN Vasopressin V2 receptor (V2R) DMCMD93 MT DTT DMCMD93 MA Inhibitor DMCMD93 RN Tetrahydroquinoline sulfonamides as vasopressin 1b receptor antagonists. Bioorg Med Chem Lett. 2009 Nov 1;19(21):6018-22. DMCMD93 RU https://pubmed.ncbi.nlm.nih.gov/19800231 DMA0QZH DI DMA0QZH DMA0QZH DN SSR-180575 DMA0QZH MI TTPTXIN DMA0QZH MN Translocator protein (TSPO) DMA0QZH MT DTT DMA0QZH MA Inhibitor DMA0QZH RN SSR180575 (7-chloro-N,N,5-trimethyl-4-oxo-3-phenyl-3,5-dihydro-4H-pyridazino[4,5-b]indole-1-acetamide), a peripheral benzodiazepine receptor ligand, promotes neuronal survival and repair. J PharmacolExp Ther. 2002 Jun;301(3):1067-78. DMA0QZH RU https://pubmed.ncbi.nlm.nih.gov/12023539 DMVZ01T DI DMVZ01T DMVZ01T DN SSR240600 DMVZ01T MI TTZPO1L DMVZ01T MN Substance-P receptor (TACR1) DMVZ01T MT DTT DMVZ01T MA Antagonist DMVZ01T RN SSR240600 [(R)-2-(1-[2-[4-[2-[3,5-bis(trifluoromethyl)phenyl]acetyl]-2-(3,4-dichlorophenyl)-2-morpholinyl]ethyl]- 4-piperidinyl)-2-methylpropanamide], a centrally active nonpeptide antagonist of the tachykinin neurokinin-1 receptor: I. biochemical and pharmacological characterization. J Pharmacol Exp Ther. 2002 Dec;303(3):1171-9. DMVZ01T RU https://pubmed.ncbi.nlm.nih.gov/12438541 DMFNZPY DI DMFNZPY DMFNZPY DN SSR-240612 DMFNZPY MI TTG5QIA DMFNZPY MN B1 bradykinin receptor (BDKRB1) DMFNZPY MT DTT DMFNZPY MA Antagonist DMFNZPY RN The kinin B1 receptor antagonist SSR240612 reverses tactile and cold allodynia in an experimental rat model of insulin resistance. Br J Pharmacol. 2007 September; 152(2): 280-287. DMFNZPY RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1978253/ DMGTB2Q DI DMGTB2Q DMGTB2Q DN SSR411298 DMGTB2Q MI TTDP1UC DMGTB2Q MN Fatty acid amide hydrolase (FAAH) DMGTB2Q MT DTT DMGTB2Q MA Inhibitor DMGTB2Q RN Pharma & Vaccines. Product Development Pipeline. April 29 2009. DMGTB2Q RU http://en.sanofi-aventis.com/binaries/RD_Phase_III_EN_tcm28-24007.pdf DMRGTZ2 DI DMRGTZ2 DMRGTZ2 DN SSTarbaclofen DMRGTZ2 MI TTDCVZW DMRGTZ2 MN Gamma-aminobutyric acid B receptor (GABBR) DMRGTZ2 MT DTT DMRGTZ2 MA Modulator DMRGTZ2 RN Reversal of disease-related pathologies in the fragile X mouse model by selective activation of GABAB receptors with arbaclofen. Sci Transl Med. 2012 Sep 19;4(152):152ra128. DMRGTZ2 RU https://www.ncbi.nlm.nih.gov/pubmed/22993295 DMH4C3M DI DMH4C3M DMH4C3M DN STA-5326 DMH4C3M MI TTRTK6Y DMH4C3M MN Interleukin-12 alpha (IL12A) DMH4C3M MT DTT DMH4C3M MA Inhibitor DMH4C3M RN Therapeutic effect of the potent IL-12/IL-23 inhibitor STA-5326 on experimental autoimmune uveoretinitis. Arthritis Res Ther. 2008;10(5):R122. DMH4C3M RU https://pubmed.ncbi.nlm.nih.gov/18847496 DMEG4TC DI DMEG4TC DMEG4TC DN Stannsoporfin DMEG4TC MI TTI6V2A DMEG4TC MN Heme oxygenase 1 (HMOX1) DMEG4TC MT DTT DMEG4TC MA Inhibitor DMEG4TC RN Chemoprevention of severe neonatal hyperbilirubinemia. Semin Perinatol. 2004 Oct;28(5):365-8. DMEG4TC RU https://pubmed.ncbi.nlm.nih.gov/15686268 DMJ1DIB DI DMJ1DIB DMJ1DIB DN S-tenatoprazole DMJ1DIB MI TTLOKXP DMJ1DIB MN Gastric H(+)/K(+) ATPase (Proton pump) DMJ1DIB MT DTT DMJ1DIB MA Modulator DMJ1DIB RN Tenatoprazole, a novel proton pump inhibitor with a prolonged plasma half-life: effects on intragastric pH and comparison with esomeprazole in heal... Aliment Pharmacol Ther. 2004 Mar 15;19(6):655-62. DMJ1DIB RU https://www.ncbi.nlm.nih.gov/pubmed/15023167 DMKVBL8 DI DMKVBL8 DMKVBL8 DN Stenoparib DMKVBL8 MI TTVDSZ0 DMKVBL8 MN Poly [ADP-ribose] polymerase 1 (PARP1) DMKVBL8 MT DTT DMKVBL8 MA Inhibitor DMKVBL8 RN Clinical pipeline report, company report or official report of Allarity Therapeutics. DMKVBL8 RU https://allarity.com/pipeline/stenoparib/ DMKVBL8 DI DMKVBL8 DMKVBL8 DN Stenoparib DMKVBL8 MI TTQ4V96 DMKVBL8 MN Poly [ADP-ribose] polymerase 2 (PARP2) DMKVBL8 MT DTT DMKVBL8 MA Inhibitor DMKVBL8 RN Clinical pipeline report, company report or official report of Allarity Therapeutics. DMKVBL8 RU https://allarity.com/pipeline/stenoparib/ DMKVBL8 DI DMKVBL8 DMKVBL8 DN Stenoparib DMKVBL8 MI TTVUSO7 DMKVBL8 MN Tankyrase-1 (TNKS-1) DMKVBL8 MT DTT DMKVBL8 MA Inhibitor DMKVBL8 RN Clinical pipeline report, company report or official report of Allarity Therapeutics. DMKVBL8 RU https://allarity.com/pipeline/stenoparib/ DMKVBL8 DI DMKVBL8 DMKVBL8 DN Stenoparib DMKVBL8 MI TTFQI4H DMKVBL8 MN Tankyrase-2 (TNKS-2) DMKVBL8 MT DTT DMKVBL8 MA Inhibitor DMKVBL8 RN Clinical pipeline report, company report or official report of Allarity Therapeutics. DMKVBL8 RU https://allarity.com/pipeline/stenoparib/ DMR9COG DI DMR9COG DMR9COG DN STX-100 DMR9COG MI TTIQSVM DMR9COG MN Integrin alpha-V/beta-6 (ITGAV/B6) DMR9COG MT DTT DMR9COG MA Antagonist DMR9COG RN Integrin-mediated regulation of TGFbeta in fibrosis. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease Volume 1832, Issue 7, July 2013, Pages 891-896. DMR9COG RU http://www.sciencedirect.com/science/article/pii/S0925443912002281 DMLNKX7 DI DMLNKX7 DMLNKX7 DN STX-107 DMLNKX7 MI TTHS256 DMLNKX7 MN Metabotropic glutamate receptor 5 (mGluR5) DMLNKX7 MT DTT DMLNKX7 MA Antagonist DMLNKX7 RN Social Communication is an Emerging Target for Pharmacotherapy in Autism Spectrum Disorder - A Review of the Literature on Potential Agents. J Can Acad Child Adolesc Psychiatry. 2014 February; 23(1):20-30. DMLNKX7 RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3917666/ DMJK5CT DI DMJK5CT DMJK5CT DN STX-140 DMJK5CT MI TTANPDJ DMJK5CT MN Carbonic anhydrase II (CA-II) DMJK5CT MT DTT DMJK5CT MA Inhibitor DMJK5CT RN Structure-activity relationships of C-17 cyano-substituted estratrienes as anticancer agents. J Med Chem. 2008 Mar 13;51(5):1295-308. DMJK5CT RU https://pubmed.ncbi.nlm.nih.gov/18260615 DMJK5CT DI DMJK5CT DMJK5CT DN STX-140 DMJK5CT MI TTHM0R1 DMJK5CT MN Steryl-sulfatase (STS) DMJK5CT MT DTT DMJK5CT MA Inhibitor DMJK5CT RN 2-substituted estradiol bis-sulfamates, multitargeted antitumor agents: synthesis, in vitro SAR, protein crystallography, and in vivo activity. J Med Chem. 2006 Dec 28;49(26):7683-96. DMJK5CT RU https://pubmed.ncbi.nlm.nih.gov/17181151 DMO9LBE DI DMO9LBE DMO9LBE DN SUN N4057 DMO9LBE MI TTSQIFT DMO9LBE MN 5-HT 1A receptor (HTR1A) DMO9LBE MT DTT DMO9LBE MA Agonist DMO9LBE RN Experimental study of pharmacological hypothermia: enhanced neuroprotective effect of a novel 5-HT 1 A agonist SUN N4057 by the pharmacological hypothermia. No To Shinkei. 2001 Sep;53(9):853-8. DMO9LBE RU https://pubmed.ncbi.nlm.nih.gov/11596480 DMPK34E DI DMPK34E DMPK34E DN Sun13834 DMPK34E MI TT8VUE0 DMPK34E MN Chymase (CYM) DMPK34E MT DTT DMPK34E MA Modulator DMPK34E RN Oral chymase inhibitor SUN13834 ameliorates skin inflammation as well as pruritus in mouse model for atopic dermatitis.Eur J Pharmacol.2008 Dec 28;601(1-3):186-91. DMPK34E RU https://www.ncbi.nlm.nih.gov/pubmed/18996112 DMPK34E DI DMPK34E DMPK34E DN Sun13834 DMPK34E MI DECB0K3 DMPK34E MN Cytochrome P450 2D6 (CYP2D6) DMPK34E MT DME DMPK34E MA Metabolism DMPK34E RN Summary of information on human CYP enzymes: human P450 metabolism data. Drug Metab Rev. 2002 Feb-May;34(1-2):83-448. DMPK34E RU https://www.ncbi.nlm.nih.gov/pubmed/?term=11996015 DMPK34E DI DMPK34E DMPK34E DN Sun13834 DMPK34E MI TTV5CGO DMPK34E MN Phosphodiesterase 4 (PDE4) DMPK34E MT DTT DMPK34E MA Inhibitor DMPK34E RN Ocular hypotension induced by topical dopaminergic drugs and phosphodiesterase inhibitors. Eur J Pharmacol. 1994 Jun 2;258(1-2):85-94. DMPK34E RU https://pubmed.ncbi.nlm.nih.gov/7925603 DMSWPA6 DI DMSWPA6 DMSWPA6 DN Superoxide dismutase DMSWPA6 MI TT6RVLG DMSWPA6 MN Superoxide dismutase Cu-Zn (SOD Cu-Zn) DMSWPA6 MT DTT DMSWPA6 MA Modulator DMSWPA6 RN Polyhemoglobin-superoxide dismutase-catalase-carbonic anhydrase: a novel biotechnology-based blood substitute that transports both oxygen and carbon dioxide and also acts as an antioxidant.Artif Cells Blood Substit Immobil Biotechnol.2011 Jun;39(3):127-36. DMSWPA6 RU https://www.ncbi.nlm.nih.gov/pubmed/21574914 DMAIGTE DI DMAIGTE DMAIGTE DN SurVaxM DMAIGTE MI TTTPU1G DMAIGTE MN Apoptosis inhibitor survivin (BIRC5) DMAIGTE MT DTT DMAIGTE MA Inhibitor DMAIGTE RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMAIGTE RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DM2KQ71 DI DM2KQ71 DM2KQ71 DN Sutezolid DM2KQ71 MI TT2VX74 DM2KQ71 MN Bacterial Protein synthesis (Bact PROS) DM2KQ71 MT DTT DM2KQ71 MA Modulator DM2KQ71 RN Cellular pharmacodynamics of the novel biaryloxazolidinone radezolid: studies with infected phagocytic and nonphagocytic cells, using Staphylococcus aureus, Staphylococcus epidermidis, Listeria monocytogenes, and Legionella pneumophila. Antimicrob Agents Chemother. 2010 Jun;54(6):2549-59. DM2KQ71 RU https://pubmed.ncbi.nlm.nih.gov/20385852 DM2KQ71 DI DM2KQ71 DM2KQ71 DN Sutezolid DM2KQ71 MI DE4LYSA DM2KQ71 MN Cytochrome P450 3A4 (CYP3A4) DM2KQ71 MT DME DM2KQ71 MA Metabolism DM2KQ71 RN TB and HIV therapeutics: pharmacology research priorities. AIDS Res Treat. 2012;2012:874083. DM2KQ71 RU https://www.hindawi.com/journals/art/2012/874083/ DMQD753 DI DMQD753 DMQD753 DN SUVN-502 DMQD753 MI TTJS8PY DMQD753 MN 5-HT 6 receptor (HTR6) DMQD753 MT DTT DMQD753 MA Antagonist DMQD753 RN Novel and Potent 5-Piperazinyl Methyl-N1-aryl Sulfonyl Indole Derivatives as 5-HT6 Receptor Ligands. ACS Med Chem Lett. 2010 October 14; 1(7): 340-344. DMQD753 RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4007800/ DMZV27P DI DMZV27P DMZV27P DN SXC-2023 DMZV27P MI TTBZMIO DMZV27P MN Cystine/glutamate transporter (SLC7A11) DMZV27P MT DTT DMZV27P MA Activator DMZV27P RN Clinical pipeline report, company report or official report of Promentis Pharmaceuticals. DMZV27P RU https://promentispharma.com/technology/sxc-2023/ DMXLE71 DI DMXLE71 DMXLE71 DN SYL-040012 DMXLE71 MI TTG8ZWP DMXLE71 MN ADRB2 messenger RNA (ADRB2 mRNA) DMXLE71 MT DTT DMXLE71 RN In vitro and in vivo efficacy of SYL040012, a novel siRNA compound for treatment of glaucoma. Mol Ther. 2014 Jan;22(1):81-91. DMXLE71 RU https://pubmed.ncbi.nlm.nih.gov/24025749 DMDF7XB DI DMDF7XB DMDF7XB DN SYN120 DMDF7XB MI TTJQOD7 DMDF7XB MN 5-HT 2A receptor (HTR2A) DMDF7XB MT DTT DMDF7XB MA Antagonist DMDF7XB RN Therapeutic strategies for Parkinson disease: beyond dopaminergic drugs. Nat Rev Drug Discov. 2018 Nov;17(11):804-822. DMDF7XB RU https://pubmed.ncbi.nlm.nih.gov/30262889 DMDF7XB DI DMDF7XB DMDF7XB DN SYN120 DMDF7XB MI TTJS8PY DMDF7XB MN 5-HT 6 receptor (HTR6) DMDF7XB MT DTT DMDF7XB MA Antagonist DMDF7XB RN Therapeutic strategies for Parkinson disease: beyond dopaminergic drugs. Nat Rev Drug Discov. 2018 Nov;17(11):804-822. DMDF7XB RU https://pubmed.ncbi.nlm.nih.gov/30262889 DMPW0UL DI DMPW0UL DMPW0UL DN SYN-120 DMPW0UL MI TTJS8PY DMPW0UL MN 5-HT 6 receptor (HTR6) DMPW0UL MT DTT DMPW0UL MA Antagonist DMPW0UL RN The Serotonin-6 Receptor as a Novel Therapeutic Target. Exp Neurobiol. 2011 December; 20(4): 159-168. DMPW0UL RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3268149/ DMF9Z2T DI DMF9Z2T DMF9Z2T DN T-2007 DMF9Z2T MI TTEX6LM DMF9Z2T MN GABA(A) receptor gamma-3 (GABRG3) DMF9Z2T MT DTT DMF9Z2T MA Agonist DMF9Z2T RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 415). DMF9Z2T RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=415 DM06GDC DI DM06GDC DM06GDC DN T2c-001 DM06GDC MI TTXQYT6 DM06GDC MN T-cells (T-cells) DM06GDC MT DTT DM06GDC MA Modulator DM06GDC RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015 DM06GDC RU https://www.accessdata.fda.gov/scripts/cder/drugsatfda/ DM5C70M DI DM5C70M DM5C70M DN T-607 DM5C70M MI TTYFKSZ DM5C70M MN Tubulin beta (TUBB) DM5C70M MT DTT DM5C70M MA Inhibitor DM5C70M RN Nucleophilic reactions of N-ethoxycarbonyliminopyridinium ylide with alpha,beta-unsaturated carbonyl compounds. Volume 28, Issue 6, 1972, Pages 1469-1476. DM5C70M RU http://www.sciencedirect.com/science/article/pii/0040402072880293 DMD72F4 DI DMD72F4 DMD72F4 DN T-817MA DMD72F4 MI TTE4KHA DMD72F4 MN Amyloid beta A4 protein (APP) DMD72F4 MT DTT DMD72F4 MA Inhibitor DMD72F4 RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMD72F4 RU http://phrma-docs.phrma.org/files/dmfile/MID_Neurological-Disorders-Drug-List_2018.pdf DMD72F4 DI DMD72F4 DMD72F4 DN T-817MA DMD72F4 MI TTV0YFR DMD72F4 MN Lipid peroxidation (LPO) DMD72F4 MT DTT DMD72F4 MA Modulator DMD72F4 RN A neuroprotective agent, T-817MA (1-{3-[2-(1-benzothiophen-5-yl)ethoxy]propyl} azetidin-3-ol maleate), prevents 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced neurotoxicity in mice. Neuropharmacology. 2008 Oct;55(5):654-60. DMD72F4 RU https://pubmed.ncbi.nlm.nih.gov/18573265 DM4JFMZ DI DM4JFMZ DM4JFMZ DN T-82 DM4JFMZ MI TT1RS9F DM4JFMZ MN Acetylcholinesterase (AChE) DM4JFMZ MT DTT DM4JFMZ MA Inhibitor DM4JFMZ RN Effects of T-82, a novel acetylcholinesterase inhibitor, on impaired learning and memory in passive avoidance task in rats. Eur J Pharmacol. 2003 Mar 28;465(1-2):97-103. DM4JFMZ RU https://pubmed.ncbi.nlm.nih.gov/12650838 DMMWPSQ DI DMMWPSQ DMMWPSQ DN TA-2005 DMMWPSQ MI TT2CJVK DMMWPSQ MN Adrenergic receptor beta-2 (ADRB2) DMMWPSQ MT DTT DMMWPSQ MA Agonist DMMWPSQ RN Emerging drugs for the treatment of chronic obstructive pulmonary disease. Expert Opin Emerg Drugs. 2006 May;11(2):275-91. DMMWPSQ RU https://pubmed.ncbi.nlm.nih.gov/16634702 DMZ7I51 DI DMZ7I51 DMZ7I51 DN TA-270 DMZ7I51 MI TT2J34L DMZ7I51 MN Arachidonate 5-lipoxygenase (5-LOX) DMZ7I51 MT DTT DMZ7I51 MA Inhibitor DMZ7I51 RN TA-270 [4-hydroxy-1-methyl-3-octyloxy-7-sinapinoylamino-2(1H)-quinolinone], an anti-asthmatic agent, inhibits leukotriene production induced by IgE... J Pharmacol Exp Ther. 2003 Nov;307(2):583-8. DMZ7I51 RU https://pubmed.ncbi.nlm.nih.gov/12970384 DMZTAJL DI DMZTAJL DMZTAJL DN TA-7906 DMZTAJL MI TTZ97H5 DMZTAJL MN Phosphodiesterase 4A (PDE4A) DMZTAJL MT DTT DMZTAJL MA Inhibitor DMZTAJL RN Potential role of phosphodiesterase 7 in human T cell function: comparative effects of two phosphodiesterase inhibitors. Clin Exp Immunol. 2002 Jun;128(3):460-6. DMZTAJL RU https://pubmed.ncbi.nlm.nih.gov/12067300 DMZTAJL DI DMZTAJL DMZTAJL DN TA-7906 DMZTAJL MI TTVIAT9 DMZTAJL MN Phosphodiesterase 4B (PDE4B) DMZTAJL MT DTT DMZTAJL MA Inhibitor DMZTAJL RN Potential role of phosphodiesterase 7 in human T cell function: comparative effects of two phosphodiesterase inhibitors. Clin Exp Immunol. 2002 Jun;128(3):460-6. DMZTAJL RU https://pubmed.ncbi.nlm.nih.gov/12067300 DMZTAJL DI DMZTAJL DMZTAJL DN TA-7906 DMZTAJL MI TTSKMI8 DMZTAJL MN Phosphodiesterase 4D (PDE4D) DMZTAJL MT DTT DMZTAJL MA Inhibitor DMZTAJL RN Potential role of phosphodiesterase 7 in human T cell function: comparative effects of two phosphodiesterase inhibitors. Clin Exp Immunol. 2002 Jun;128(3):460-6. DMZTAJL RU https://pubmed.ncbi.nlm.nih.gov/12067300 DMAZHT0 DI DMAZHT0 DMAZHT0 DN TA-8995 DMAZHT0 MI TTFQAYR DMAZHT0 MN Cholesteryl ester transfer protein (CETP) DMAZHT0 MT DTT DMAZHT0 MA Inhibitor DMAZHT0 RN Amgen To Acquire Privately-Held Dezima Pharma DMAZHT0 RU http://www.amgen.com/media/media_pr_detail.jsp?releaseID=2088272 DMNL9HO DI DMNL9HO DMNL9HO DN Tabimorelin DMNL9HO MI TTWDC17 DMNL9HO MN Growth hormone secretagogue receptor 1 (GHSR) DMNL9HO MT DTT DMNL9HO MA Modulator DMNL9HO RN Pharmacological characterisation of a new oral GH secretagogue, NN703. Eur J Endocrinol. 1999 Aug;141(2):180-9. DMNL9HO RU https://pubmed.ncbi.nlm.nih.gov/10427162 DMP1873 DI DMP1873 DMP1873 DN TAK-063 DMP1873 MI TTJW4LU DMP1873 MN Phosphodiesterase 10A (PDE10) DMP1873 MT DTT DMP1873 MA Inhibitor DMP1873 RN Characterization of Binding and Inhibitory Properties of TAK-063, a Novel Phosphodiesterase 10A Inhibitor. PLoS One. 2015; 10(3): e0122197. DMP1873 RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4376699/ DMHPEFS DI DMHPEFS DMHPEFS DN TAK-128 DMHPEFS MI TT2O84V DMHPEFS MN Thromboxane A2 receptor (TBXA2R) DMHPEFS MT DTT DMHPEFS MA Modulator DMHPEFS RN ClinicalTrials.gov (NCT00229437) Efficacy and Safety Study of TAK-128 in Treating Subjects With Diabetic Peripheral Neuropathy. U.S. National Institutes of Health. DMHPEFS RU https://clinicaltrials.gov/ct2/show/NCT00229437 DM81UAZ DI DM81UAZ DM81UAZ DN TAK-272 DM81UAZ MI TTB2MXP DM81UAZ MN Angiotensinogenase renin (REN) DM81UAZ MT DTT DM81UAZ MA Modulator DM81UAZ RN Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800033655) DM81UAZ RU http://adisinsight.springer.com/drugs/800033655 DMEYKRN DI DMEYKRN DMEYKRN DN TAK-379 DMEYKRN MI TTCBFJO DMEYKRN MN Insulin receptor (INSR) DMEYKRN MT DTT DMEYKRN MA Modulator DMEYKRN RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1800). DMEYKRN RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1800 DMD51RN DI DMD51RN DMD51RN DN TAK-448 DMD51RN MI TTU2O6T DMD51RN MN Metastasis-suppressor KiSS-1 (KISS1) DMD51RN MT DTT DMD51RN MA Modulator DMD51RN RN Pharmacologic profiles of investigational kisspeptin/metastin analogues, TAK-448 and TAK-683, in adult male rats in comparison to the GnRH analogue leuprolide.Eur J Pharmacol.2014 Jul 15;735:77-85. DMD51RN RU https://www.ncbi.nlm.nih.gov/pubmed/24747751 DMNB4P1 DI DMNB4P1 DMNB4P1 DN TAK-653 DMNB4P1 MI TTAN6JD DMNB4P1 MN Glutamate receptor AMPA (GRIA) DMNB4P1 MT DTT DMNB4P1 MA Activator DMNB4P1 RN Antibodies and venom peptides: new modalities for ion channels. Nat Rev Drug Discov. 2019 May;18(5):339-357. DMNB4P1 RU https://pubmed.ncbi.nlm.nih.gov/30728472 DMJH3U0 DI DMJH3U0 DMJH3U0 DN TAK-659 DMJH3U0 MI TTGJCWZ DMJH3U0 MN Fms-like tyrosine kinase 3 (FLT-3) DMJH3U0 MT DTT DMJH3U0 MA Inhibitor DMJH3U0 RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMJH3U0 RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DMJH3U0 DI DMJH3U0 DMJH3U0 DN TAK-659 DMJH3U0 MI TTOU65C DMJH3U0 MN Tyrosine-protein kinase SYK (SYK) DMJH3U0 MT DTT DMJH3U0 MA Inhibitor DMJH3U0 RN J Clin Oncol 32:5s, 2014 (suppl; abstr 8580). DMJH3U0 RU http://meetinglibrary.asco.org/content/134551-144 DMZKPI8 DI DMZKPI8 DMZKPI8 DN TAK-715 DMZKPI8 MI TTWELHI DMZKPI8 MN Stress-activated protein kinase (p38) DMZKPI8 MT DTT DMZKPI8 MA Inhibitor DMZKPI8 RN Inhibition of Wnt/beta-catenin signaling by p38 MAP kinase inhibitors is explained by cross-reactivity with casein kinase Idelta/ . Chem Biol. 2011 Apr 22;18(4):485-94. DMZKPI8 RU https://pubmed.ncbi.nlm.nih.gov/21513885 DMWPSJR DI DMWPSJR DMWPSJR DN TAK-831 DMWPSJR MI TT7Y3EJ DMWPSJR MN D-amino acid oxidase (DAO) DMWPSJR MT DTT DMWPSJR MA Inhibitor DMWPSJR RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMWPSJR RU http://phrma-docs.phrma.org/files/dmfile/MID_Mental-Illness-2017-Drug-List_Final.pdf DMZEU6M DI DMZEU6M DMZEU6M DN TAK-831 DMZEU6M MI TT7Y3EJ DMZEU6M MN D-amino acid oxidase (DAO) DMZEU6M MT DTT DMZEU6M MA Inhibitor DMZEU6M RN Mechanistic Multilayer Quantitative Model for Nonlinear Pharmacokinetics, Target Occupancy and Pharmacodynamics (PK/TO/PD) Relationship of D-Amino Acid Oxidase Inhibitor, TAK-831 in Mice. Pharm Res. 2020 Aug 5;37(8):164. DMZEU6M RU https://pubmed.ncbi.nlm.nih.gov/32901384 DMBQD9H DI DMBQD9H DMBQD9H DN TAK-906 DMBQD9H MI TTEX248 DMBQD9H MN Dopamine D2 receptor (D2R) DMBQD9H MT DTT DMBQD9H MA Inhibitor DMBQD9H RN Safety, Pharmacokinetics, and Pharmacodynamics of Trazpiroben (TAK-906), a Novel Selective D 2 /D 3 Receptor Antagonist: A Phase 1 Randomized, Placebo-Controlled Single- and Multiple-Dose Escalation Study in Healthy Participants. Clin Pharmacol Drug Dev. 2021 Jan 18. DMBQD9H RU https://pubmed.ncbi.nlm.nih.gov/33462988 DMBQD9H DI DMBQD9H DMBQD9H DN TAK-906 DMBQD9H MI TT4C8EA DMBQD9H MN Dopamine D3 receptor (D3R) DMBQD9H MT DTT DMBQD9H MA Inhibitor DMBQD9H RN Safety, Pharmacokinetics, and Pharmacodynamics of Trazpiroben (TAK-906), a Novel Selective D 2 /D 3 Receptor Antagonist: A Phase 1 Randomized, Placebo-Controlled Single- and Multiple-Dose Escalation Study in Healthy Participants. Clin Pharmacol Drug Dev. 2021 Jan 18. DMBQD9H RU https://pubmed.ncbi.nlm.nih.gov/33462988 DMOZAMN DI DMOZAMN DMOZAMN DN TAK-935 DMOZAMN MI TT4EB85 DMOZAMN MN Cholesterol 24-hydroxylase (CYP46A1) DMOZAMN MT DTT DMOZAMN MA Inhibitor DMOZAMN RN Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800040983) DMOZAMN RU http://adisinsight.springer.com/drugs/800040983 DMARVFG DI DMARVFG DMARVFG DN Talacotuzumab DMARVFG MI TTENHJ0 DMARVFG MN Interleukin 3 receptor alpha (IL3RA) DMARVFG MT DTT DMARVFG RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMARVFG RU http://phrma-docs.phrma.org/files/dmfile/MID_Immuno-Oncology-2017_Drug-List1.pdf DMJOM5L DI DMJOM5L DMJOM5L DN Talampanel DMJOM5L MI TTAN6JD DMJOM5L MN Glutamate receptor AMPA (GRIA) DMJOM5L MT DTT DMJOM5L MA Antagonist DMJOM5L RN Talampanel suppresses the acute and chronic effects of seizures in a rodent neonatal seizure model. Epilepsia. 2009 Apr;50(4):694-701. DMJOM5L RU https://pubmed.ncbi.nlm.nih.gov/19220413 DMQKZDT DI DMQKZDT DMQKZDT DN Talnetant DMQKZDT MI TTBPGLU DMQKZDT MN Neuromedin-K receptor (TACR3) DMQKZDT MT DTT DMQKZDT MA Antagonist DMQKZDT RN Pharmacological characterization of senktide-induced tail whips. Neuropharmacology. 2010 Jan;58(1):259-67. DMQKZDT RU https://pubmed.ncbi.nlm.nih.gov/19540857 DMNLQHK DI DMNLQHK DMNLQHK DN Tanespimycin DMNLQHK MI TT78R5H DMNLQHK MN Heat shock protein 90 alpha (HSP90A) DMNLQHK MT DTT DMNLQHK MA Inhibitor DMNLQHK RN Tanespimycin: the opportunities and challenges of targeting heat shock protein 90. Expert Opin Investig Drugs. 2009 Jun;18(6):861-8. DMNLQHK RU https://pubmed.ncbi.nlm.nih.gov/19466875 DM1TSHL DI DM1TSHL DM1TSHL DN Taprenepag DM1TSHL MI TT1ZAVI DM1TSHL MN Prostaglandin E2 receptor EP2 (PTGER2) DM1TSHL MT DTT DM1TSHL MA Agonist DM1TSHL RN A phase 2, randomized, dose-response trial of taprenepag isopropyl (PF-04217329) versus latanoprost 0.005% in open-angle glaucoma and ocular hypertension. Curr Eye Res. 2011 Sep;36(9):809-17. DM1TSHL RU https://pubmed.ncbi.nlm.nih.gov/21851167 DMDB4EJ DI DMDB4EJ DMDB4EJ DN Tarafenacin DMDB4EJ MI TTQ13Z5 DMDB4EJ MN Muscarinic acetylcholine receptor M3 (CHRM3) DMDB4EJ MT DTT DMDB4EJ MA Antagonist DMDB4EJ RN In vivo and in vitro pharmacological characterization of SVT-40776, a novel M3 muscarinic receptor antagonist, for the treatment of overactive bladder. Br J Pharmacol. 2009 Mar;156(5):807-17. DMDB4EJ RU https://pubmed.ncbi.nlm.nih.gov/19222482 DM95FR3 DI DM95FR3 DM95FR3 DN Tarextumab DM95FR3 MI TT82FVD DM95FR3 MN Notch-2 receptor (NOTCH2) DM95FR3 MT DTT DM95FR3 MA Modulator DM95FR3 RN Company report (OncoMed Pharmaceuticals) DM95FR3 RU http://www.oncomed.com/Pipeline.html DM95FR3 DI DM95FR3 DM95FR3 DN Tarextumab DM95FR3 MI TTVX7IA DM95FR3 MN Notch-3 receptor (NOTCH3) DM95FR3 MT DTT DM95FR3 MA Modulator DM95FR3 RN Company report (OncoMed Pharmaceuticals) DM95FR3 RU http://www.oncomed.com/Pipeline.html DMA7ISF DI DMA7ISF DMA7ISF DN Tarloxotinib DMA7ISF MI TTGKNB4 DMA7ISF MN Epidermal growth factor receptor (EGFR) DMA7ISF MT DTT DMA7ISF MA Inhibitor DMA7ISF RN Tarloxotinib Is a Hypoxia-Activated Pan-HER Kinase Inhibitor Active Against a Broad Range of HER-Family Oncogenes. Clin Cancer Res. 2021 Mar 1;27(5):1463-1475. DMA7ISF RU https://pubmed.ncbi.nlm.nih.gov/33355298 DMA7ISF DI DMA7ISF DMA7ISF DN Tarloxotinib DMA7ISF MI TT6EO5L DMA7ISF MN Erbb2 tyrosine kinase receptor (HER2) DMA7ISF MT DTT DMA7ISF MA Inhibitor DMA7ISF RN Tarloxotinib Is a Hypoxia-Activated Pan-HER Kinase Inhibitor Active Against a Broad Range of HER-Family Oncogenes. Clin Cancer Res. 2021 Mar 1;27(5):1463-1475. DMA7ISF RU https://pubmed.ncbi.nlm.nih.gov/33355298 DML97KB DI DML97KB DML97KB DN TAS-106 DML97KB MI TT79JGK DML97KB MN Mycobacterium RNA polymerase (MycB RNAP) DML97KB MT DTT DML97KB MA Modulator DML97KB RN Phase I and pharmacokinetic study of 3'-C-ethynylcytidine (TAS-106), an inhibitor of RNA polymerase I, II and III,in patients with advanced solid malignancies.Invest New Drugs.2012 Feb;30(1):316-26. DML97KB RU https://www.ncbi.nlm.nih.gov/pubmed/20839029 DM3D52L DI DM3D52L DM3D52L DN TAS-114 DM3D52L MI TTH6MBO DM3D52L MN dUTP pyrophosphatase (DUT) DM3D52L MT DTT DM3D52L MA Inhibitor DM3D52L RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DM3D52L RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DM9QFW2 DI DM9QFW2 DM9QFW2 DN Tau-binding PET tracer DM9QFW2 MI TTS87KH DM9QFW2 MN Microtubule-associated protein tau (MAPT) DM9QFW2 MT DTT DM9QFW2 MA Modulator DM9QFW2 RN Microtubules (tau) as an emerging therapeutic target: NAP (davunetide). Curr Pharm Des. 2011;17(31):3413-7. DM9QFW2 RU https://pubmed.ncbi.nlm.nih.gov/21902667 DMZX0VF DI DMZX0VF DMZX0VF DN Tavokinogene telseplasmid DMZX0VF MI TTG68FB DMZX0VF MN Interleukine 12 (IL-12) DMZX0VF MT DTT DMZX0VF MA Replacement DMZX0VF RN Intratumoral delivery of tavokinogene telseplasmid yields systemic immune responses in metastatic melanoma patients. Ann Oncol. 2020 Apr;31(4):532-540. DMZX0VF RU https://pubmed.ncbi.nlm.nih.gov/32147213 DM4I6XK DI DM4I6XK DM4I6XK DN TB-402 DM4I6XK MI TT1290U DM4I6XK MN Coagulation factor VIII (F8) DM4I6XK MT DTT DM4I6XK RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2607). DM4I6XK RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2607 DMDPBMH DI DMDPBMH DMDPBMH DN TB-403 DMDPBMH MI TT48I1Y DMDPBMH MN Placenta growth factor (PlGF) DMDPBMH MT DTT DMDPBMH MA Inhibitor DMDPBMH RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMDPBMH RU http://phrma-docs.phrma.org/files/dmfile/MID_Immuno-Oncology-2017_Drug-List1.pdf DMZTOJ6 DI DMZTOJ6 DMZTOJ6 DN TBA-7371 DMZTOJ6 MI TTLOHU4 DMZTOJ6 MN Mycobacterium Decaprenylphosphoryl-beta-D-ribose oxidase (McyB dprE1) DMZTOJ6 MT DTT DMZTOJ6 MA Inhibitor DMZTOJ6 RN Clinical pipeline report, company report or official report of TB Alliance. DMZTOJ6 RU https://www.tballiance.org/portfolio/trial/12010 DMZCA0K DI DMZCA0K DMZCA0K DN TBC-3711 DMZCA0K MI TTKRD0G DMZCA0K MN Endothelin A receptor (EDNRA) DMZCA0K MT DTT DMZCA0K MA Antagonist DMZCA0K RN TBC3711, an ET(A) receptor antagonist, reduces neonatal hypoxia-induced pulmonary hypertension in piglets. Pediatr Res. 2001 Sep;50(3):374-83. DMZCA0K RU https://pubmed.ncbi.nlm.nih.gov/11518825 DMM5BVG DI DMM5BVG DMM5BVG DN TBR-760 DMM5BVG MI TTEX248 DMM5BVG MN Dopamine D2 receptor (D2R) DMM5BVG MT DTT DMM5BVG MA Agonist DMM5BVG RN TBR-760, a Dopamine-Somatostatin Compound, Arrests Growth of Aggressive Nonfunctioning Pituitary Adenomas in Mice. Endocrinology. 2020 Aug 1;161(8):bqaa101. DMM5BVG RU https://pubmed.ncbi.nlm.nih.gov/32591776 DMM5BVG DI DMM5BVG DMM5BVG DN TBR-760 DMM5BVG MI TTZ6T9E DMM5BVG MN Somatostatin receptor type 2 (SSTR2) DMM5BVG MT DTT DMM5BVG MA Agonist DMM5BVG RN TBR-760, a Dopamine-Somatostatin Compound, Arrests Growth of Aggressive Nonfunctioning Pituitary Adenomas in Mice. Endocrinology. 2020 Aug 1;161(8):bqaa101. DMM5BVG RU https://pubmed.ncbi.nlm.nih.gov/32591776 DM8AM60 DI DM8AM60 DM8AM60 DN TC-5214 DM8AM60 MI TT35UGH DM8AM60 MN Neuronal acetylcholine receptor alpha-3/beta-4 (CHRNA3/B4) DM8AM60 MT DTT DM8AM60 MA Antagonist DM8AM60 RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DM8AM60 RU http://phrma-docs.phrma.org/files/dmfile/MID_Skin_Diseases_2018_9_FINAL.pdf DM8AM60 DI DM8AM60 DM8AM60 DN TC-5214 DM8AM60 MI TT5KPZR DM8AM60 MN Neuronal acetylcholine receptor beta-2 (CHRNB2) DM8AM60 MT DTT DM8AM60 MA Antagonist DM8AM60 RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DM8AM60 RU http://phrma-docs.phrma.org/files/dmfile/MID_Skin_Diseases_2018_9_FINAL.pdf DMWPI2U DI DMWPI2U DMWPI2U DN TC-6499-12 DMWPI2U MI TTL1ATN DMWPI2U MN Neuronal acetylcholine receptor alpha-4/beta-2 (CHRNA4/B2) DMWPI2U MT DTT DMWPI2U MA Modulator DMWPI2U RN Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41. DMWPI2U RU https://www.ncbi.nlm.nih.gov/pubmed/15950434 DMNFP21 DI DMNFP21 DMNFP21 DN TC-6987 DMNFP21 MI TTLA931 DMNFP21 MN Neuronal acetylcholine receptor alpha-7 (CHRNA7) DMNFP21 MT DTT DMNFP21 MA Modulator DMNFP21 RN ClinicalTrials.gov (NCT01293669) Glycemic Control, Safety and Tolerability of TC-6987 Monotherapy in Type 2 Diabetes Mellitus. U.S. National Institutes of Health. DMNFP21 RU https://clinicaltrials.gov/ct2/show/NCT01293669 DM9PVNJ DI DM9PVNJ DM9PVNJ DN TCN-032 DM9PVNJ MI TTXT3PU DM9PVNJ MN Influenza M2 protein (Influ M) DM9PVNJ MT DTT DM9PVNJ RN Human antibodies reveal a protective epitope that is highly conserved among human and nonhuman influenza A viruses. Proc Natl Acad Sci U S A. 2010 July 13; 107(28): 12658-12663. DM9PVNJ RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2906546/ DMJ3KPO DI DMJ3KPO DMJ3KPO DN TD-101 DMJ3KPO MI TT2FX8W DMJ3KPO MN Keratin 6A messenger RNA (KRT6A mRNA) DMJ3KPO MT DTT DMJ3KPO RN First-in-human mutation-targeted siRNA phase Ib trial of an inherited skin disorder. Mol Ther. 2010 Feb;18(2):442-6. DMJ3KPO RU https://pubmed.ncbi.nlm.nih.gov/19935778 DMTJMK5 DI DMTJMK5 DMTJMK5 DN TD-1211 DMTJMK5 MI TTKWM86 DMTJMK5 MN Opioid receptor mu (MOP) DMTJMK5 MT DTT DMTJMK5 MA Modulator DMTJMK5 RN The in vitro pharmacological profile of TD-1211, a neutral opioid receptor antagonist. Naunyn Schmiedebergs Arch Pharmacol. 2013 Jun;386(6):479-91. DMTJMK5 RU https://pubmed.ncbi.nlm.nih.gov/23549670 DM6SANW DI DM6SANW DM6SANW DN TD-5108 DM6SANW MI TT07C3Y DM6SANW MN 5-HT 4 receptor (HTR4) DM6SANW MT DTT DM6SANW MA Agonist DM6SANW RN The in vitro pharmacological profile of TD-5108, a selective 5-HT(4) receptor agonist with high intrinsic activity. Naunyn Schmiedebergs Arch Pharmacol. 2008 Jul;378(1):125-37. DM6SANW RU https://pubmed.ncbi.nlm.nih.gov/18415081 DM3C9NV DI DM3C9NV DM3C9NV DN TD-8954 DM3C9NV MI TT07C3Y DM3C9NV MN 5-HT 4 receptor (HTR4) DM3C9NV MT DTT DM3C9NV MA Modulator DM3C9NV RN The Pharmacology of TD-8954, a Potent and Selective 5-HT(4) Receptor Agonist with Gastrointestinal Prokinetic Properties. Front Pharmacol. 2011 May 30;2:25. DM3C9NV RU https://pubmed.ncbi.nlm.nih.gov/21687517 DMQD5NA DI DMQD5NA DMQD5NA DN TD-9855 DMQD5NA MI TTAWNKZ DMQD5NA MN Norepinephrine transporter (NET) DMQD5NA MT DTT DMQD5NA MA Modulator DMQD5NA RN Preclinical to clinical translation of CNS transporter occupancy of TD-9855, a novel norepinephrine and serotonin reuptake inhibitor. Int J Neuropsychopharmacol. 2014 Dec 13;18(2). pii: pyu027. DMQD5NA RU https://pubmed.ncbi.nlm.nih.gov/25522383 DMQD5NA DI DMQD5NA DMQD5NA DN TD-9855 DMQD5NA MI TT3ROYC DMQD5NA MN Serotonin transporter (SERT) DMQD5NA MT DTT DMQD5NA MA Modulator DMQD5NA RN Preclinical to clinical translation of CNS transporter occupancy of TD-9855, a novel norepinephrine and serotonin reuptake inhibitor. Int J Neuropsychopharmacol. 2014 Dec 13;18(2). pii: pyu027. DMQD5NA RU https://pubmed.ncbi.nlm.nih.gov/25522383 DM6YI5T DI DM6YI5T DM6YI5T DN Tegobuvir DM6YI5T MI TTMVBWH DM6YI5T MN Hepatitis C virus RNA-directed RNA polymerase (HCV NS5B) DM6YI5T MT DTT DM6YI5T MA Inhibitor DM6YI5T RN Clinical pipeline report, company report or official report of Gilead (2011). DM6YI5T RU http://www.gilead.com/ DM9AWSO DI DM9AWSO DM9AWSO DN Telapristone DM9AWSO MI TTUV8G9 DM9AWSO MN Progesterone receptor (PGR) DM9AWSO MT DTT DM9AWSO MA Antagonist DM9AWSO RN In vitro antiprogestational/antiglucocorticoid activity and progestin and glucocorticoid receptor binding of the putative metabolites and synthetic derivatives of CDB-2914, CDB-4124, and mifepristone. J Steroid Biochem Mol Biol. 2004 Mar;88(3):277-88. DM9AWSO RU https://pubmed.ncbi.nlm.nih.gov/15120421 DMFT5D6 DI DMFT5D6 DMFT5D6 DN Telcagepant DMFT5D6 MI TTY6O0Q DMFT5D6 MN Calcitonin gene-related peptide receptor (CGRPR) DMFT5D6 MT DTT DMFT5D6 MA Antagonist DMFT5D6 RN CGRP antagonists: novel concept for treatment of migraine. Med Monatsschr Pharm. 2009 May;32(5):182-5. DMFT5D6 RU https://pubmed.ncbi.nlm.nih.gov/19469188 DM8UCNK DI DM8UCNK DM8UCNK DN Telisotuzumab vedotin DM8UCNK MI TTNDSF4 DM8UCNK MN Proto-oncogene c-Met (MET) DM8UCNK MT DTT DM8UCNK RN Clinical pipeline report, company report or official report of AbbVie. DM8UCNK RU https://www.abbvie.com/our-science/pipeline/abbv-399.html DMUQH78 DI DMUQH78 DMUQH78 DN Tempol DMUQH78 MI TT6RVLG DMUQH78 MN Superoxide dismutase Cu-Zn (SOD Cu-Zn) DMUQH78 MT DTT DMUQH78 MA Modulator DMUQH78 RN The superoxide dismutase mimetic, tempol, reduces the bioavailability of nitric oxide and does not alter L-NAME-induced hypertension in rats. Basic Clin Pharmacol Toxicol. 2005 Jul;97(1):29-34. DMUQH78 RU https://www.ncbi.nlm.nih.gov/pubmed/15943756 DMVS61L DI DMVS61L DMVS61L DN Tepoxalin DMVS61L MI TT2J34L DMVS61L MN Arachidonate 5-lipoxygenase (5-LOX) DMVS61L MT DTT DMVS61L MA Inhibitor DMVS61L RN Preclinical toxicity evaluation of tepoxalin, a dual inhibitor of cyclooxygenase and 5-lipoxygenase, in Sprague-Dawley rats and beagle dogs. Fundam Appl Toxicol. 1996 Sep;33(1):38-48. DMVS61L RU https://pubmed.ncbi.nlm.nih.gov/8812216 DMVS61L DI DMVS61L DMVS61L DN Tepoxalin DMVS61L MI TTLGTKB DMVS61L MN Interleukin-4 (IL4) DMVS61L MT DTT DMVS61L MA Inhibitor DMVS61L RN Therapeutic interference with interferon-gamma (IFN-gamma) and soluble IL-4 receptor (sIL-4R) in allergic diseases. Behring Inst Mitt. 1995 Jun;(96):118-30. DMVS61L RU https://pubmed.ncbi.nlm.nih.gov/7575347 DMC3P45 DI DMC3P45 DMC3P45 DN Terameprocol DMC3P45 MI TTZEP6S DMC3P45 MN Transcription factor Sp1 (SP1) DMC3P45 MT DTT DMC3P45 MA Modulator DMC3P45 RN Terameprocol, a novel site-specific transcription inhibitor with anticancer activity. IDrugs. 2008 Mar;11(3):204-14. DMC3P45 RU https://pubmed.ncbi.nlm.nih.gov/18311658 DMZNFPG DI DMZNFPG DMZNFPG DN Terguride DMZNFPG MI DE4LYSA DMZNFPG MN Cytochrome P450 3A4 (CYP3A4) DMZNFPG MT DME DMZNFPG MA Metabolism DMZNFPG RN Cytochromes P450 and experimental models of drug metabolism. J Cell Mol Med. 2002 Apr-Jun;6(2):189-98. DMZNFPG RU https://www.ncbi.nlm.nih.gov/pubmed/?term=12169204 DMR4YEG DI DMR4YEG DMR4YEG DN Tesidolumab DMR4YEG MI TTKANGO DMR4YEG MN Complement C5 (CO5) DMR4YEG MT DTT DMR4YEG MA Inhibitor DMR4YEG RN Intravenous immunoglobulin significantly reduces exposure of concomitantly administered anti-C5 monoclonal antibody tesidolumab. Am J Transplant. 2020 Sep;20(9):2581-2588. DMR4YEG RU https://pubmed.ncbi.nlm.nih.gov/32301258 DM1KGS7 DI DM1KGS7 DM1KGS7 DN Tesofensine DM1KGS7 MI TTCBFJO DM1KGS7 MN Insulin receptor (INSR) DM1KGS7 MT DTT DM1KGS7 MA Inhibitor DM1KGS7 RN The novel triple monoamine reuptake inhibitor tesofensine induces sustained weight loss and improves glycemic control in the diet-induced obese rat: comparison to sibutramine and rimonabant. Eur J Pharmacol. 2010 Jun 25;636(1-3):88-95. DM1KGS7 RU https://pubmed.ncbi.nlm.nih.gov/20385125 DMMK6IT DI DMMK6IT DMMK6IT DN Testogen TDS DMMK6IT MI TTS64P2 DMMK6IT MN Androgen receptor (AR) DMMK6IT MT DTT DMMK6IT MA Modulator DMMK6IT RN Evidence for a role of testosterone-androgen receptor interactions in mediating masculine sexual behavior in male rats. Endocrinology. 1989 Feb;124(2):618-26. DMMK6IT RU https://pubmed.ncbi.nlm.nih.gov/2912689 DMR5GSB DI DMR5GSB DMR5GSB DN Tetrahydrouridine DMR5GSB MI TTQ12RK DMR5GSB MN Cytidine deaminase (CDA) DMR5GSB MT DTT DMR5GSB MA Modulator DMR5GSB RN Tetrahydrouridine inhibits cell proliferation through cell cycle regulation regardless of cytidine deaminase expression levels. PLoS One. 2012;7(5):e37424. DMR5GSB RU https://pubmed.ncbi.nlm.nih.gov/22616006 DMGNK67 DI DMGNK67 DMGNK67 DN TETRAPLATIN TETRANITRATE DMGNK67 MI TTUTN1I DMGNK67 MN Human Deoxyribonucleic acid (hDNA) DMGNK67 MT DTT DMGNK67 MA Binder DMGNK67 RN Differential cytotoxicity, uptake and DNA binding of tetraplatin and analogous isomers in sensitive and resistant cancer cell lines. Anticancer Drugs. 1993 Apr;4(2):251-8. DMGNK67 RU https://pubmed.ncbi.nlm.nih.gov/8490203 DM2LBC3 DI DM2LBC3 DM2LBC3 DN TEW-7197 DM2LBC3 MI TTP4520 DM2LBC3 MN TGF-beta receptor type I (TGFBR1) DM2LBC3 MT DTT DM2LBC3 MA Modulator DM2LBC3 RN Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41. DM2LBC3 RU https://www.ncbi.nlm.nih.gov/pubmed/15950434 DM2LBC3 DI DM2LBC3 DM2LBC3 DN TEW-7197 DM2LBC3 MI TTO3HT7 DM2LBC3 MN Transforming growth factor beta (TGFB) DM2LBC3 MT DTT DM2LBC3 MA Antagonist DM2LBC3 RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DM2LBC3 RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DMF61ML DI DMF61ML DMF61ML DN TF0023 DMF61ML MI TT6L509 DMF61ML MN Coagulation factor IIa (F2) DMF61ML MT DTT DMF61ML MA Inhibitor DMF61ML RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMF61ML RU http://phrma-docs.phrma.org/files/dmfile/mid-diabetes-drug-list.pdf DM2ZLWH DI DM2ZLWH DM2ZLWH DN TG-0054 DM2ZLWH MI TTBID49 DM2ZLWH MN C-X-C chemokine receptor type 4 (CXCR4) DM2ZLWH MT DTT DM2ZLWH MA Inhibitor DM2ZLWH RN CXCR4 Antagonist TG-0054 Mobilizes Mesenchymal Stem Cells, Attenuates Inflammation, and Preserves Cardiac Systolic Function in a Porcine Model of Myocardial Infarction. Cell Transplant. 2015;24(7):1313-28. DM2ZLWH RU https://pubmed.ncbi.nlm.nih.gov/24823505 DMPH1AG DI DMPH1AG DMPH1AG DN TG100801 DMPH1AG MI TT9HKJA DMPH1AG MN Vascular endothelial growth factor (VEGF) DMPH1AG MT DTT DMPH1AG MA Inhibitor DMPH1AG RN Topical administration of a multi-targeted kinase inhibitor suppresses choroidal neovascularization and retinal edema. J Cell Physiol. 2008 Jul;216(1):29-37. DMPH1AG RU https://pubmed.ncbi.nlm.nih.gov/18330892 DMZ571Y DI DMZ571Y DMZ571Y DN TG-2349 DMZ571Y MI TTRHUKY DMZ571Y MN Hepatitis C virus Serine protease NS4A (HCV NS4A) DMZ571Y MT DTT DMZ571Y MA Modulator DMZ571Y RN Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41. DMZ571Y RU https://www.ncbi.nlm.nih.gov/pubmed/15950434 DMJ2FTU DI DMJ2FTU DMJ2FTU DN TGBA01AD DMJ2FTU MI TTSQIFT DMJ2FTU MN 5-HT 1A receptor (HTR1A) DMJ2FTU MT DTT DMJ2FTU MA Modulator DMJ2FTU RN Company report (Fabrekramer) DMJ2FTU RU http://www.fabrekramer.com/?page_id=66 DMJ2FTU DI DMJ2FTU DMJ2FTU DN TGBA01AD DMJ2FTU MI TT6MSOK DMJ2FTU MN 5-HT 1D receptor (HTR1D) DMJ2FTU MT DTT DMJ2FTU MA Modulator DMJ2FTU RN Company report (Fabrekramer) DMJ2FTU RU http://www.fabrekramer.com/?page_id=66 DMNXJ5B DI DMNXJ5B DMNXJ5B DN TGFK08AA DMNXJ5B MI TTSQIFT DMNXJ5B MN 5-HT 1A receptor (HTR1A) DMNXJ5B MT DTT DMNXJ5B MA Modulator DMNXJ5B RN 50 years of hurdles and hope in anxiolytic drug discovery. Nat Rev Drug Discov. 2013 Sep;12(9):667-87. DMNXJ5B RU https://pubmed.ncbi.nlm.nih.gov/23989795 DMGWE4H DI DMGWE4H DMGWE4H DN TGFK09SD DMGWE4H MI TTSQIFT DMGWE4H MN 5-HT 1A receptor (HTR1A) DMGWE4H MT DTT DMGWE4H MA Modulator DMGWE4H RN Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800032503) DMGWE4H RU http://adisinsight.springer.com/drugs/800032503 DMQ6ANE DI DMQ6ANE DMQ6ANE DN TGOF02N DMQ6ANE MI TTYSN63 DMQ6ANE MN 5-HT 2 receptor (5HT2R) DMQ6ANE MT DTT DMQ6ANE MA Modulator DMQ6ANE RN Clinical pipeline report, company report or official report of Fabre-Kramer Pharmaceuticals. DMQ6ANE RU http://www.fabrekramer.com/?page_id=76 DMI57ZA DI DMI57ZA DMI57ZA DN TGWOOAA DMI57ZA MI TTSQIFT DMI57ZA MN 5-HT 1A receptor (HTR1A) DMI57ZA MT DTT DMI57ZA MA Antagonist DMI57ZA RN Clinical pipeline report, company report or official report of Fabre-Kramer Pharmaceuticals. DMI57ZA RU http://www.fabrekramer.com/?page_id=70 DMI57ZA DI DMI57ZA DMI57ZA DN TGWOOAA DMI57ZA MI TTYSN63 DMI57ZA MN 5-HT 2 receptor (5HT2R) DMI57ZA MT DTT DMI57ZA MA Antagonist DMI57ZA RN Clinical pipeline report, company report or official report of Fabre-Kramer Pharmaceuticals. DMI57ZA RU http://www.fabrekramer.com/?page_id=70 DMFU0JY DI DMFU0JY DMFU0JY DN TH-302 DMFU0JY MI TTUTN1I DMFU0JY MN Human Deoxyribonucleic acid (hDNA) DMFU0JY MT DTT DMFU0JY MA Modulator DMFU0JY RN Company report (Threshold Pharmaceuticals) DMFU0JY RU http://www.thresholdpharm.com/what-is-th-302 DMW8X05 DI DMW8X05 DMW8X05 DN THR-149 DMW8X05 MI TTMF8H9 DMW8X05 MN Plasma kallikrein (KLKB1) DMW8X05 MT DTT DMW8X05 MA Inhibitor DMW8X05 RN Clinical pipeline report, company report or official report of Oxurion. DMW8X05 RU https://www.oxurion.com/product/thr-149-pkal-inhibitor DMBO021 DI DMBO021 DMBO021 DN THR-18 DMBO021 MI TTTO43N DMBO021 MN Endothelial plasminogen activator inhibitor (SERPINE1) DMBO021 MT DTT DMBO021 MA Activator DMBO021 RN THR-18, a 18-mer peptide derived from PAI-1, is neuroprotective and improves thrombolysis by tPA in rat stroke models. Neurol Res. 2011 Nov;33(9):983-90. DMBO021 RU https://pubmed.ncbi.nlm.nih.gov/22081002 DMAVQR1 DI DMAVQR1 DMAVQR1 DN THR-184 DMAVQR1 MI TTKOBRA DMAVQR1 MN Bone morphogenetic protein 7 (BMP7) DMAVQR1 MT DTT DMAVQR1 MA Agonist DMAVQR1 RN Perioperative THR-184 and AKI after Cardiac Surgery. J Am Soc Nephrol. 2018 Feb;29(2):670-679. DMAVQR1 RU https://pubmed.ncbi.nlm.nih.gov/29203473 DM1BYNF DI DM1BYNF DM1BYNF DN THRX-198321 DM1BYNF MI TT2CJVK DM1BYNF MN Adrenergic receptor beta-2 (ADRB2) DM1BYNF MT DTT DM1BYNF MA Modulator DM1BYNF RN THRX-198321 is a bifunctional muscarinic receptor antagonist and beta2-adrenoceptor agonist (MABA) that binds in a bimodal and multivalent manner. Mol Pharmacol. 2011 Mar;79(3):389-99. DM1BYNF RU https://pubmed.ncbi.nlm.nih.gov/21139051 DM4BLJM DI DM4BLJM DM4BLJM DN Thymoctonan DM4BLJM MI TTF89GD DM4BLJM MN Interleukin-2 (IL2) DM4BLJM MT DTT DM4BLJM MA Modulator DM4BLJM RN Evaluation of efficacy and safety of thymus humoral factor-gamma 2 in the management of chronic hepatitis B. J Hepatol. 1995 Jul;23(1):21-7. DM4BLJM RU https://pubmed.ncbi.nlm.nih.gov/8530805 DME4LA1 DI DME4LA1 DME4LA1 DN Tideglusib DME4LA1 MI TTRSMW9 DME4LA1 MN Glycogen synthase kinase-3 beta (GSK-3B) DME4LA1 MT DTT DME4LA1 MA Inhibitor DME4LA1 RN Evidence for irreversible inhibition of glycogen synthase kinase-3beta by tideglusib. J Biol Chem. 2012 Jan 6;287(2):893-904. DME4LA1 RU https://pubmed.ncbi.nlm.nih.gov/22102280 DM5XRMA DI DM5XRMA DM5XRMA DN Tipapkinogene sovacivec DM5XRMA MI TTE2N95 DM5XRMA MN Human papillomavirus protein E6 (HPV E6) DM5XRMA MT DTT DM5XRMA MA Modulator DM5XRMA RN Immune therapy for human papillomaviruses-related cancers DM5XRMA RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4259927 DM5XRMA DI DM5XRMA DM5XRMA DN Tipapkinogene sovacivec DM5XRMA MI TT3CPZW DM5XRMA MN Human papillomavirus protein E7 (HPV E7) DM5XRMA MT DTT DM5XRMA MA Modulator DM5XRMA RN Immune therapy for human papillomaviruses-related cancers DM5XRMA RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4259927 DMS9BDQ DI DMS9BDQ DMS9BDQ DN Tipelukast DMS9BDQ MI TT2J34L DMS9BDQ MN Arachidonate 5-lipoxygenase (5-LOX) DMS9BDQ MT DTT DMS9BDQ MA Modulator DMS9BDQ RN Company report (MediciNova) DMS9BDQ RU http://medicinova.com/clinical-development/core/mn-001-nash/ DMS9BDQ DI DMS9BDQ DMS9BDQ DN Tipelukast DMS9BDQ MI TTZCG4L DMS9BDQ MN Phosphodiesterase 3 (PDE3) DMS9BDQ MT DTT DMS9BDQ MA Modulator DMS9BDQ RN Company report (MediciNova) DMS9BDQ RU http://medicinova.com/clinical-development/core/mn-001-nash/ DM1SB94 DI DM1SB94 DM1SB94 DN Tiprelestat DM1SB94 MI TT5MLC4 DM1SB94 MN Leukocyte proteinase-3 (PRTN3) DM1SB94 MT DTT DM1SB94 MA Modulator DM1SB94 RN Company report (Proteo Biotech AG) DM1SB94 RU http://proteo.us/proteo-inc/r-und-d/lead-product-elafin.html DM1SB94 DI DM1SB94 DM1SB94 DN Tiprelestat DM1SB94 MI TTPLTSQ DM1SB94 MN Neutrophil elastase (NE) DM1SB94 MT DTT DM1SB94 MA Modulator DM1SB94 RN Company report (Proteo Biotech AG) DM1SB94 RU http://proteo.us/proteo-inc/r-und-d/lead-product-elafin.html DMT8SMO DI DMT8SMO DMT8SMO DN TKA-731 DMT8SMO MI TTZPO1L DMT8SMO MN Substance-P receptor (TACR1) DMT8SMO MT DTT DMT8SMO MA Antagonist DMT8SMO RN The NK1-receptor antagonist TKA731 in painful diabetic neuropathy: a randomised, controlled trial. Eur J Pain. 2006 Aug;10(6):567-71. DMT8SMO RU https://pubmed.ncbi.nlm.nih.gov/16199188 DMGWP8L DI DMGWP8L DMGWP8L DN TLC-388 DMGWP8L MI TTGTQHC DMGWP8L MN DNA topoisomerase I (TOP1) DMGWP8L MT DTT DMGWP8L MA Inhibitor DMGWP8L RN Topotecan - A novel topoisomerase I inhibitor: pharmacology and clinical experience. Oncology. 1999;56(1):1-12. DMGWP8L RU https://pubmed.ncbi.nlm.nih.gov/9885371 DMVXLQ7 DI DMVXLQ7 DMVXLQ7 DN TLN-4601 DMVXLQ7 MI TTPTXIN DMVXLQ7 MN Translocator protein (TSPO) DMVXLQ7 MT DTT DMVXLQ7 MA Modulator DMVXLQ7 RN TLN-4601 peripheral benzodiazepine receptor (PBR/TSPO) binding properties do not mediate apoptosis but confer tumor-specific accumulation.Biochem Pharmacol.2010 Nov 15;80(10):1572-9. DMVXLQ7 RU https://www.ncbi.nlm.nih.gov/pubmed/20655882 DMKV5UM DI DMKV5UM DMKV5UM DN TM-601 DMKV5UM MI TTCYAXN DMKV5UM MN Chloride channel unspecific (ClC) DMKV5UM MT DTT DMKV5UM MA Inhibitor DMKV5UM RN NMR sequential assignments and solution structure of chlorotoxin, a small scorpion toxin that blocks chloride channels. Biochemistry. 1995 Jan 10;34(1):13-21. DMKV5UM RU https://pubmed.ncbi.nlm.nih.gov/7819188 DMW145U DI DMW145U DMW145U DN TMC-310911 DMW145U MI TT5FNQT DMW145U MN Human immunodeficiency virus Protease (HIV PR) DMW145U MT DTT DMW145U MA Inhibitor DMW145U RN Oral Druggable Space beyond the Rule of 5: Insights from Drugs and Clinical Candidates. Chemistry & Biology Volume 21, Issue 9, 18 September 2014, Pages 1115-1142. DMW145U RU http://www.sciencedirect.com/science/article/pii/S1074552114002890 DME8PFQ DI DME8PFQ DME8PFQ DN TMX-049 DME8PFQ MI TT7RJY8 DME8PFQ MN Xanthine dehydrogenase/oxidase (XDH) DME8PFQ MT DTT DME8PFQ MA Inhibitor DME8PFQ RN Clinical pipeline report, company report or official report of Teijin Pharma. DME8PFQ RU https://www.teijin.com/news/2019/20190920_3737.html DMH4BFD DI DMH4BFD DMH4BFD DN TN-871 DMH4BFD MI TTTD45S DMH4BFD MN Neurotransmitter release (NT rele) DMH4BFD MT DTT DMH4BFD MA Modulator DMH4BFD RN Effects of an indene-derivative, TN-871, on synaptic transmission in a sympathetic ganglion: presynaptic actions on neurotransmitter release. Bull Tokyo Med Dent Univ. 1995 Mar;42(1):19-29. DMH4BFD RU https://pubmed.ncbi.nlm.nih.gov/7895315 DM3AIF7 DI DM3AIF7 DM3AIF7 DN TNF alpha kinoid DM3AIF7 MI TTF8CQI DM3AIF7 MN Tumor necrosis factor (TNF) DM3AIF7 MT DTT DM3AIF7 RN Modulation of Anti-Tumor Necrosis Factor Alpha (TNF-alpha) Antibody Secretion in Mice Immunized with TNF-alpha Kinoid. Clin Vaccine Immunol. 2012 May; 19(5): 699-703. DM3AIF7 RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3346328/ DM8DZKI DI DM8DZKI DM8DZKI DN TNP-2092 DM8DZKI MI TTN6J5F DM8DZKI MN Bacterial DNA gyrase (Bact gyrase) DM8DZKI MT DTT DM8DZKI MA Inhibitor DM8DZKI RN Clinical pipeline report, company report or official report of TenNor Therapeutics. DM8DZKI RU http://www.tennorx.com/en/h-col-158.html DM8DZKI DI DM8DZKI DM8DZKI DN TNP-2092 DM8DZKI MI TTFK8YB DM8DZKI MN Bacterial DNA topoisomerase 4A (Bact parC) DM8DZKI MT DTT DM8DZKI MA Inhibitor DM8DZKI RN Clinical pipeline report, company report or official report of TenNor Therapeutics. DM8DZKI RU http://www.tennorx.com/en/h-col-158.html DMAJ6YL DI DMAJ6YL DMAJ6YL DN TNX-1300 DMAJ6YL MI TTX7ZJ3 DMAJ6YL MN Cocaine (Coca) DMAJ6YL MT DTT DMAJ6YL MA Degrader DMAJ6YL RN Clinical pipeline report, company report or official report of Tonix Pharmaceuticals. DMAJ6YL RU https://www.tonixpharma.com/pipeline/overview DMBIJZ6 DI DMBIJZ6 DMBIJZ6 DN Tocopherol DMBIJZ6 MI DE4LYSA DMBIJZ6 MN Cytochrome P450 3A4 (CYP3A4) DMBIJZ6 MT DME DMBIJZ6 MA Metabolism DMBIJZ6 RN A new compound-specific pleiotropic effect of statins: modification of plasma gamma-tocopherol levels. Atherosclerosis. 2007 Jul;193(1):229-33. DMBIJZ6 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=16860808 DMBIJZ6 DI DMBIJZ6 DMBIJZ6 DN Tocopherol DMBIJZ6 MI DE3GT9C DMBIJZ6 MN Cytochrome P450 4F2 (CYP4F2) DMBIJZ6 MT DME DMBIJZ6 MA Metabolism DMBIJZ6 RN Discovery, characterization, and significance of the cytochrome P450 omega-hydroxylase pathway of vitamin E catabolism. Ann N Y Acad Sci. 2004 Dec;1031:13-21. DMBIJZ6 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=15753130 DMLCUAS DI DMLCUAS DMLCUAS DN TOFIMILAST DMLCUAS MI TTZ97H5 DMLCUAS MN Phosphodiesterase 4A (PDE4A) DMLCUAS MT DTT DMLCUAS MA Inhibitor DMLCUAS RN GSK256066, an exceptionally high-affinity and selective inhibitor of phosphodiesterase 4 suitable for administration by inhalation: in vitro, kinetic, and in vivo characterization. J Pharmacol Exp Ther. 2011 Apr;337(1):145-54. DMLCUAS RU https://pubmed.ncbi.nlm.nih.gov/21205923 DMLCUAS DI DMLCUAS DMLCUAS DN TOFIMILAST DMLCUAS MI TTVIAT9 DMLCUAS MN Phosphodiesterase 4B (PDE4B) DMLCUAS MT DTT DMLCUAS MA Inhibitor DMLCUAS RN Therapeutic target database update 2012: a resource for facilitating target-oriented drug discovery. Nucleic Acids Res. 2012 Jan;40(Database issue):D1128-36. DMLCUAS RU https://pubmed.ncbi.nlm.nih.gov/21948793 DMLCUAS DI DMLCUAS DMLCUAS DN TOFIMILAST DMLCUAS MI TTSKMI8 DMLCUAS MN Phosphodiesterase 4D (PDE4D) DMLCUAS MT DTT DMLCUAS MA Inhibitor DMLCUAS RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015 DMLCUAS RU https://www.accessdata.fda.gov/scripts/cder/drugsatfda/ DMTGNWU DI DMTGNWU DMTGNWU DN Tofisopam DMTGNWU MI TTJW4LU DMTGNWU MN Phosphodiesterase 10A (PDE10) DMTGNWU MT DTT DMTGNWU MA Inhibitor DMTGNWU RN The atypical anxiolytic drug, tofisopam, selectively blocks phosphodiesterase isoenzymes and is active in the mouse model of negative symptoms of psychosis. J Neural Transm (Vienna). 2010 Nov;117(11):1319-25. DMTGNWU RU https://pubmed.ncbi.nlm.nih.gov/20967473 DMTGNWU DI DMTGNWU DMTGNWU DN Tofisopam DMTGNWU MI TTJGW1Z DMTGNWU MN Phosphodiesterase 2A (PDE2A) DMTGNWU MT DTT DMTGNWU MA Inhibitor DMTGNWU RN The atypical anxiolytic drug, tofisopam, selectively blocks phosphodiesterase isoenzymes and is active in the mouse model of negative symptoms of psychosis. J Neural Transm (Vienna). 2010 Nov;117(11):1319-25. DMTGNWU RU https://pubmed.ncbi.nlm.nih.gov/20967473 DMTGNWU DI DMTGNWU DMTGNWU DN Tofisopam DMTGNWU MI TTZCG4L DMTGNWU MN Phosphodiesterase 3 (PDE3) DMTGNWU MT DTT DMTGNWU MA Inhibitor DMTGNWU RN The atypical anxiolytic drug, tofisopam, selectively blocks phosphodiesterase isoenzymes and is active in the mouse model of negative symptoms of psychosis. J Neural Transm (Vienna). 2010 Nov;117(11):1319-25. DMTGNWU RU https://pubmed.ncbi.nlm.nih.gov/20967473 DMTGNWU DI DMTGNWU DMTGNWU DN Tofisopam DMTGNWU MI TTZ97H5 DMTGNWU MN Phosphodiesterase 4A (PDE4A) DMTGNWU MT DTT DMTGNWU MA Inhibitor DMTGNWU RN The atypical anxiolytic drug, tofisopam, selectively blocks phosphodiesterase isoenzymes and is active in the mouse model of negative symptoms of psychosis. J Neural Transm (Vienna). 2010 Nov;117(11):1319-25. DMTGNWU RU https://pubmed.ncbi.nlm.nih.gov/20967473 DMVJWPR DI DMVJWPR DMVJWPR DN TOK-001 DMVJWPR MI TTS64P2 DMVJWPR MN Androgen receptor (AR) DMVJWPR MT DTT DMVJWPR MA Inhibitor DMVJWPR RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 8638). DMVJWPR RU http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=8638 DMW17KS DI DMW17KS DMW17KS DN TOL-3021 DMW17KS MI TTUTN1I DMW17KS MN Human Deoxyribonucleic acid (hDNA) DMW17KS MT DTT DMW17KS MA Modulator DMW17KS RN Clinical pipeline report, company report or official report of Tolerion. DMW17KS RU http://www.tolerioninc.com/TOL-3021_press_release.html DMORFZD DI DMORFZD DMORFZD DN Tolamba DMORFZD MI TTSHG0T DMORFZD MN Toll-like receptor 9 (TLR9) DMORFZD MT DTT DMORFZD RN Phase II study of a TLR-9 agonist (1018 ISS) with rituximab in patients with relapsed or refractory follicular lymphoma. Br J Haematol. 2009 August; 146(3): 282-291. DMORFZD RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2747261/ DMT4OPL DI DMT4OPL DMT4OPL DN Tonabersat DMT4OPL MI TT6MSOK DMT4OPL MN 5-HT 1D receptor (HTR1D) DMT4OPL MT DTT DMT4OPL MA Agonist DMT4OPL RN The potential anti-migraine compound SB-220453 does not contract human isolated blood vessels or myocardium; a comparison with sumatriptan. Cephalalgia. 2000 Jul;20(6):538-45. DMT4OPL RU https://pubmed.ncbi.nlm.nih.gov/11075836 DMBH316 DI DMBH316 DMBH316 DN Tonapofylline DMBH316 MI TTK25J1 DMBH316 MN Adenosine A1 receptor (ADORA1) DMBH316 MT DTT DMBH316 MA Inhibitor DMBH316 RN 2-Amino-5-benzoyl-4-phenylthiazoles: Development of potent and selective adenosine A1 receptor antagonists. Bioorg Med Chem. 2010 Mar 15;18(6):2195-2203. DMBH316 RU https://pubmed.ncbi.nlm.nih.gov/20188574 DMBH316 DI DMBH316 DMBH316 DN Tonapofylline DMBH316 MI TTM2AOE DMBH316 MN Adenosine A2a receptor (ADORA2A) DMBH316 MT DTT DMBH316 MA Inhibitor DMBH316 RN 2-Amino-5-benzoyl-4-phenylthiazoles: Development of potent and selective adenosine A1 receptor antagonists. Bioorg Med Chem. 2010 Mar 15;18(6):2195-2203. DMBH316 RU https://pubmed.ncbi.nlm.nih.gov/20188574 DMBH316 DI DMBH316 DMBH316 DN Tonapofylline DMBH316 MI TTNE7KG DMBH316 MN Adenosine A2b receptor (ADORA2B) DMBH316 MT DTT DMBH316 MA Inhibitor DMBH316 RN 2-Amino-5-benzoyl-4-phenylthiazoles: Development of potent and selective adenosine A1 receptor antagonists. Bioorg Med Chem. 2010 Mar 15;18(6):2195-2203. DMBH316 RU https://pubmed.ncbi.nlm.nih.gov/20188574 DMBH316 DI DMBH316 DMBH316 DN Tonapofylline DMBH316 MI TTJFY5U DMBH316 MN Adenosine A3 receptor (ADORA3) DMBH316 MT DTT DMBH316 MA Inhibitor DMBH316 RN 2-Amino-5-benzoyl-4-phenylthiazoles: Development of potent and selective adenosine A1 receptor antagonists. Bioorg Med Chem. 2010 Mar 15;18(6):2195-2203. DMBH316 RU https://pubmed.ncbi.nlm.nih.gov/20188574 DMA04DE DI DMA04DE DMA04DE DN Topiroxostat DMA04DE MI DE85D2P DMA04DE MN UDP-glucuronosyltransferase 1A9 (UGT1A9) DMA04DE MT DME DMA04DE MA Metabolism DMA04DE RN Characterization of N-glucuronidation of 4-(5-pyridin-4-yl-1H-[1,2,4]triazol-3-yl) pyridine-2-carbonitrile (FYX-051): a new xanthine oxidoreductase inhibitor. Drug Metab Dispos. 2007 Dec;35(12):2143-8. DMA04DE RU https://www.ncbi.nlm.nih.gov/pubmed/?term=17761779 DMA04DE DI DMA04DE DMA04DE DN Topiroxostat DMA04DE MI TT7RJY8 DMA04DE MN Xanthine dehydrogenase/oxidase (XDH) DMA04DE MT DTT DMA04DE MA Inhibitor DMA04DE RN QT/QTc study conducted in Japanese adult healthy subjects: a novel xanthine oxidase inhibitor topiroxostat was not associated with QT prolongation. J Clin Pharmacol. 2014 Apr;54(4):446-52. DMA04DE RU https://pubmed.ncbi.nlm.nih.gov/24214189 DM2HDTM DI DM2HDTM DM2HDTM DN Tosagestin DM2HDTM MI TTUV8G9 DM2HDTM MN Progesterone receptor (PGR) DM2HDTM MT DTT DM2HDTM MA Agonist DM2HDTM RN Effects of progestins on the proliferation of estrogen-dependent human breast cancer cells under growth factor-defined conditions. J Steroid Biochem Mol Biol. 1992 Jun;42(5):457-65. DM2HDTM RU https://pubmed.ncbi.nlm.nih.gov/1616875 DMAWLVB DI DMAWLVB DMAWLVB DN TPI ASM8 DMAWLVB MI TTPYS82 DMAWLVB MN Interleukin 3 receptor (CSF2RB) DMAWLVB MT DTT DMAWLVB MA Modulator DMAWLVB RN Target mRNA inhibition by oligonucleotide drugs in man. Nucleic Acids Res.2012 Nov;40(21):10585-95. DMAWLVB RU https://www.ncbi.nlm.nih.gov/pubmed/22989709 DMSA2LZ DI DMSA2LZ DMSA2LZ DN TPI-1020 DMSA2LZ MI TTYRL6O DMSA2LZ MN Glucocorticoid receptor (NR3C1) DMSA2LZ MT DTT DMSA2LZ MA Antagonist DMSA2LZ RN Bronchoprotection in conscious guinea pigs by budesonide and the NO-donating analogue, TPI 1020, alone and combined with tiotropium or formoterol. Br J Pharmacol. 2012 Oct;167(3):515-26. DMSA2LZ RU https://pubmed.ncbi.nlm.nih.gov/22563753 DMC5TV6 DI DMC5TV6 DMC5TV6 DN TPI-287 DMC5TV6 MI TT1WDO0 DMC5TV6 MN Microtubule (MicroTu) DMC5TV6 MT DTT DMC5TV6 MA Stabilizer DMC5TV6 RN TPI-287, a new taxane family member, reduces the brain metastatic colonization of breast cancer cells. Mol Cancer Ther. 2012 Sep;11(9):1959-67. DMC5TV6 RU https://pubmed.ncbi.nlm.nih.gov/22622283 DM4R23C DI DM4R23C DM4R23C DN TPM-1/Morphine DM4R23C MI TT27RFC DM4R23C MN Opioid receptor delta (OPRD1) DM4R23C MT DTT DM4R23C MA Inhibitor DM4R23C RN Molecular Mechanisms of Opioid Receptor-Dependent Signaling and Behavior. Anesthesiology. 2011 December; 115(6): 1363-1381. DM4R23C RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3698859/ DM4R23C DI DM4R23C DM4R23C DN TPM-1/Morphine DM4R23C MI TTQW87Y DM4R23C MN Opioid receptor kappa (OPRK1) DM4R23C MT DTT DM4R23C MA Inhibitor DM4R23C RN Molecular Mechanisms of Opioid Receptor-Dependent Signaling and Behavior. Anesthesiology. 2011 December; 115(6): 1363-1381. DM4R23C RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3698859/ DM4R23C DI DM4R23C DM4R23C DN TPM-1/Morphine DM4R23C MI TTKWM86 DM4R23C MN Opioid receptor mu (MOP) DM4R23C MT DTT DM4R23C MA Inhibitor DM4R23C RN Molecular Mechanisms of Opioid Receptor-Dependent Signaling and Behavior. Anesthesiology. 2011 December; 115(6): 1363-1381. DM4R23C RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3698859/ DMYP7TO DI DMYP7TO DMYP7TO DN Trametinib + 2141795 DMYP7TO MI TTWTSCV DMYP7TO MN RAC-alpha serine/threonine-protein kinase (AKT1) DMYP7TO MT DTT DMYP7TO MA Modulator DMYP7TO RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1479). DMYP7TO RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1479 DMU1LXS DI DMU1LXS DMU1LXS DN Trastuzumab Emtansine DMU1LXS MI DE7P2FB DMU1LXS MN Aldo-keto reductase 1C1 (AKR1C1) DMU1LXS MT DME DMU1LXS MA Metabolism DMU1LXS RN The role of carbonyl reducing enzymes in oxcarbazepine in vitro metabolism in man. Chem Biol Interact. 2014 Sep 5;220:241-7. DMU1LXS RU https://www.ncbi.nlm.nih.gov/pubmed/?term=25063510 DMU1LXS DI DMU1LXS DMU1LXS DN Trastuzumab Emtansine DMU1LXS MI DEOY5ZM DMU1LXS MN Aldo-keto reductase 1C2 (AKR1C2) DMU1LXS MT DME DMU1LXS MA Metabolism DMU1LXS RN The role of carbonyl reducing enzymes in oxcarbazepine in vitro metabolism in man. Chem Biol Interact. 2014 Sep 5;220:241-7. DMU1LXS RU https://www.ncbi.nlm.nih.gov/pubmed/?term=25063510 DMU1LXS DI DMU1LXS DMU1LXS DN Trastuzumab Emtansine DMU1LXS MI DEGQTXO DMU1LXS MN Aldo-keto reductase 1C3 (AKR1C3) DMU1LXS MT DME DMU1LXS MA Metabolism DMU1LXS RN The role of carbonyl reducing enzymes in oxcarbazepine in vitro metabolism in man. Chem Biol Interact. 2014 Sep 5;220:241-7. DMU1LXS RU https://www.ncbi.nlm.nih.gov/pubmed/?term=25063510 DMU1LXS DI DMU1LXS DMU1LXS DN Trastuzumab Emtansine DMU1LXS MI DEAJN47 DMU1LXS MN Aldo-keto reductase 1C4 (AKR1C4) DMU1LXS MT DME DMU1LXS MA Metabolism DMU1LXS RN The role of carbonyl reducing enzymes in oxcarbazepine in vitro metabolism in man. Chem Biol Interact. 2014 Sep 5;220:241-7. DMU1LXS RU https://www.ncbi.nlm.nih.gov/pubmed/?term=25063510 DMU1LXS DI DMU1LXS DMU1LXS DN Trastuzumab Emtansine DMU1LXS MI DE4LYSA DMU1LXS MN Cytochrome P450 3A4 (CYP3A4) DMU1LXS MT DME DMU1LXS MA Metabolism DMU1LXS RN Drug-Drug interactions of clinical significance in the treatment of patients with Mycobacterium avium complex disease. Clin Pharmacokinet. 2000 Sep;39(3):203-14. DMU1LXS RU https://www.ncbi.nlm.nih.gov/pubmed/?term=11020135 DMU1LXS DI DMU1LXS DMU1LXS DN Trastuzumab Emtansine DMU1LXS MI DEIBDNY DMU1LXS MN Cytochrome P450 3A5 (CYP3A5) DMU1LXS MT DME DMU1LXS MA Metabolism DMU1LXS RN Trastuzumab emtansine. An inadequately assessed combination of two cytotoxic drugs. Prescrire Int. 2014 Dec;23(155):289. DMU1LXS RU https://www.ncbi.nlm.nih.gov/pubmed/?term=25629144 DMU1LXS DI DMU1LXS DMU1LXS DN Trastuzumab Emtansine DMU1LXS MI DEIVKZ8 DMU1LXS MN NADPH-dependent carbonyl reductase 3 (CBR3) DMU1LXS MT DME DMU1LXS MA Metabolism DMU1LXS RN The role of carbonyl reducing enzymes in oxcarbazepine in vitro metabolism in man. Chem Biol Interact. 2014 Sep 5;220:241-7. DMU1LXS RU https://www.ncbi.nlm.nih.gov/pubmed/?term=25063510 DM1ZQEN DI DM1ZQEN DM1ZQEN DN TRAXOPRODIL MESYLATE DM1ZQEN MI TT9IK2Z DM1ZQEN MN N-methyl-D-aspartate receptor (NMDAR) DM1ZQEN MT DTT DM1ZQEN MA Modulator DM1ZQEN RN The effect of the selective NMDA receptor antagonist traxoprodil in the treatment of traumatic brain injury. J Neurotrauma. 2005 Dec;22(12):1428-43. DM1ZQEN RU https://pubmed.ncbi.nlm.nih.gov/16379581 DM7XZY5 DI DM7XZY5 DM7XZY5 DN Triapine DM7XZY5 MI TTBWDI0 DM7XZY5 MN Ribonucleoside-diphosphate reductase M2 (RRM2) DM7XZY5 MT DTT DM7XZY5 MA Modulator DM7XZY5 RN PAN-811 inhibits oxidative stress-induced cell death of human Alzheimer's disease-derived and age-matched olfactory neuroepithelial cells via suppression of intracellular reactive oxygen species. J Alzheimers Dis. 2009;17(3):611-9. DM7XZY5 RU https://pubmed.ncbi.nlm.nih.gov/19433896 DMWU41P DI DMWU41P DMWU41P DN TRIDMAC DMWU41P MI TTJSZTB DMWU41P MN Nicotinic acetylcholine receptor (nAChR) DMWU41P MT DTT DMWU41P MA Antagonist DMWU41P RN Novel drugs and therapeutic targets for severe mood disorders. Neuropsychopharmacology. 2008 Aug;33(9):2080-92. DMWU41P RU https://pubmed.ncbi.nlm.nih.gov/18172433 DM13G5R DI DM13G5R DM13G5R DN TRK-170 DM13G5R MI TT6S84X DM13G5R MN Integrin alpha-4/beta-1 (ITGA4/B1) DM13G5R MT DTT DM13G5R MA Modulator DM13G5R RN Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41. DM13G5R RU https://www.ncbi.nlm.nih.gov/pubmed/15950434 DM13G5R DI DM13G5R DM13G5R DN TRK-170 DM13G5R MI TT7ZMI1 DM13G5R MN Integrin alpha-4/beta-7 (ITGA4/B7) DM13G5R MT DTT DM13G5R MA Modulator DM13G5R RN Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41. DM13G5R RU https://www.ncbi.nlm.nih.gov/pubmed/15950434 DM64NYP DI DM64NYP DM64NYP DN TRN-157 DM64NYP MI TTQ13Z5 DM64NYP MN Muscarinic acetylcholine receptor M3 (CHRM3) DM64NYP MT DTT DM64NYP MA Antagonist DM64NYP RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 15). DM64NYP RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=15 DMMQYF6 DI DMMQYF6 DMMQYF6 DN TRO-19622 DMMQYF6 MI TTAN6JD DMMQYF6 MN Glutamate receptor AMPA (GRIA) DMMQYF6 MT DTT DMMQYF6 MA Antagonist DMMQYF6 RN Emerging disease-modifying therapies for the treatment of motor neuron disease/amyotropic lateral sclerosis. Expert Opin Emerg Drugs. 2007 May;12(2):229-52. DMMQYF6 RU https://pubmed.ncbi.nlm.nih.gov/17604499 DMR8Y4F DI DMR8Y4F DMR8Y4F DN Troplasminogen alfa DMR8Y4F MI TTP86E2 DMR8Y4F MN Plasminogen (PLG) DMR8Y4F MT DTT DMR8Y4F MA Modulator DMR8Y4F RN V-10153 (Vernalis). Curr Opin Investig Drugs. 2005 Sep;6(9):951-5. DMR8Y4F RU https://pubmed.ncbi.nlm.nih.gov/16187695 DMAZ2L6 DI DMAZ2L6 DMAZ2L6 DN TROXACITABINE DMAZ2L6 MI TTUTN1I DMAZ2L6 MN Human Deoxyribonucleic acid (hDNA) DMAZ2L6 MT DTT DMAZ2L6 MA Binder DMAZ2L6 RN Troxacitabine. Bull Cancer. 2004 Mar;91(3):213-8. DMAZ2L6 RU https://pubmed.ncbi.nlm.nih.gov/15171046 DMHEWT7 DI DMHEWT7 DMHEWT7 DN TRU-015 DMHEWT7 MI TTUE541 DMHEWT7 MN Leukocyte surface antigen Leu-16 (CD20) DMHEWT7 MT DTT DMHEWT7 MA Antagonist DMHEWT7 RN TRU-015, a small modular immunopharmaceutical (SMIP drug candidate directed against CD20, demonstrates clinical improvement in subjects with rheumatoid arthritis. Arthritis Res Ther. 2007; 9(Suppl 3): P32. DMHEWT7 RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4061958/ DMVX6H0 DI DMVX6H0 DMVX6H0 DN TRV027 DMVX6H0 MI TT8DBY3 DMVX6H0 MN Angiotensin II receptor type-1 (AGTR1) DMVX6H0 MT DTT DMVX6H0 MA Antagonist DMVX6H0 RN First clinical experience with TRV027: pharmacokinetics and pharmacodynamics in healthy volunteers. J Clin Pharmacol. 2013 Sep;53(9):892-9. DMVX6H0 RU https://pubmed.ncbi.nlm.nih.gov/23813302 DMMNXIW DI DMMNXIW DMMNXIW DN TS-022 DMMNXIW MI TTNVEIR DMMNXIW MN Prostaglandin D2 receptor (PTGDR) DMMNXIW MT DTT DMMNXIW MA Agonist DMMNXIW RN Effects of TS-022, a newly developed prostanoid DP1 receptor agonist, on experimental pruritus, cutaneous barrier disruptions and atopic dermatitis... Eur J Pharmacol. 2007 Feb 5;556(1-3):207-14. DMMNXIW RU https://pubmed.ncbi.nlm.nih.gov/17141215 DMZE6Y9 DI DMZE6Y9 DMZE6Y9 DN TT-100 DMZE6Y9 MI TTGKNB4 DMZE6Y9 MN Epidermal growth factor receptor (EGFR) DMZE6Y9 MT DTT DMZE6Y9 MA Inhibitor DMZE6Y9 RN BiPar Sciences Co-founder Reunites Management Team At TriAct Therapeutics to Advance Clinical Stage Cancer Programs. TriAct Therapeutics. Sept. 10, 2009. DMZE6Y9 RU http://globenewswire.com/news-release/2009/09/10/404398/173021/en/BiPar-Sciences-Co-founder-Reunites-Management-Team-At-TriAct-Therapeutics-to-Advance-Clinical-Stage-Cancer-Programs.html DMZE6Y9 DI DMZE6Y9 DMZE6Y9 DN TT-100 DMZE6Y9 MI TTHRID2 DMZE6Y9 MN Insulin-like growth factor I receptor (IGF1R) DMZE6Y9 MT DTT DMZE6Y9 MA Inhibitor DMZE6Y9 RN BiPar Sciences Co-founder Reunites Management Team At TriAct Therapeutics to Advance Clinical Stage Cancer Programs. TriAct Therapeutics. Sept. 10, 2009. DMZE6Y9 RU http://globenewswire.com/news-release/2009/09/10/404398/173021/en/BiPar-Sciences-Co-founder-Reunites-Management-Team-At-TriAct-Therapeutics-to-Advance-Clinical-Stage-Cancer-Programs.html DMSIXG4 DI DMSIXG4 DMSIXG4 DN TT-173 DMSIXG4 MI TT38MDJ DMSIXG4 MN Tissue factor (F3) DMSIXG4 MT DTT DMSIXG4 MA Modulator DMSIXG4 RN TETIS study: evaluation of new topical hemostatic agent TT-173 in tooth extraction. Clin Oral Investig. 2016 Jun;20(5):1055-63. DMSIXG4 RU https://pubmed.ncbi.nlm.nih.gov/26374745 DMCDMFP DI DMCDMFP DMCDMFP DN TT-223 DMCDMFP MI TTVFO0U DMCDMFP MN Gastrin/cholecystokinin type B receptor (CCKBR) DMCDMFP MT DTT DMCDMFP MA Modulator DMCDMFP RN The effect of glucagon-like peptide-1 on energy expenditure and substrate metabolism in humans. Int J Obes Relat Metab Disord. 2000 Mar;24(3):288-98. DMCDMFP RU https://pubmed.ncbi.nlm.nih.gov/10757621 DMRQ0SA DI DMRQ0SA DMRQ0SA DN TT-401 DMRQ0SA MI TT9O6WS DMRQ0SA MN Glucagon receptor (GCGR) DMRQ0SA MT DTT DMRQ0SA MA Agonist DMRQ0SA RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMRQ0SA RU http://phrma-docs.phrma.org/files/dmfile/mid-diabetes-drug-list.pdf DMRQ0SA DI DMRQ0SA DMRQ0SA DN TT-401 DMRQ0SA MI TTVIMDE DMRQ0SA MN Glucagon-like peptide 1 receptor (GLP1R) DMRQ0SA MT DTT DMRQ0SA MA Modulator DMRQ0SA RN Relationship between systemic cytokines and complement factor H Y402H polymorphism in patients with dry age-related macular degeneration. Am J Ophthalmol. 2013 Dec;156(6):1176-83. DMRQ0SA RU https://pubmed.ncbi.nlm.nih.gov/24083687 DM6TAFE DI DM6TAFE DM6TAFE DN TTAC-0001 DM6TAFE MI TTUTJGQ DM6TAFE MN Vascular endothelial growth factor receptor 2 (KDR) DM6TAFE MT DTT DM6TAFE RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1813). DM6TAFE RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1813 DMBNU1W DI DMBNU1W DMBNU1W DN TTP-054 DMBNU1W MI TTVIMDE DMBNU1W MN Glucagon-like peptide 1 receptor (GLP1R) DMBNU1W MT DTT DMBNU1W MA Modulator DMBNU1W RN Small Molecule Drug Discovery at the Glucagon-Like Peptide-1 Receptor. Exp Diabetes Res. 2012; 2012: 709893. DMBNU1W RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3352573/ DMZ6RG2 DI DMZ6RG2 DMZ6RG2 DN TTP273 DMZ6RG2 MI TTVIMDE DMZ6RG2 MN Glucagon-like peptide 1 receptor (GLP1R) DMZ6RG2 MT DTT DMZ6RG2 MA Agonist DMZ6RG2 RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMZ6RG2 RU http://phrma-docs.phrma.org/files/dmfile/mid-diabetes-drug-list.pdf DMBKQSZ DI DMBKQSZ DMBKQSZ DN TTP399 DMBKQSZ MI TTDLNGZ DMBKQSZ MN Glucokinase (GCK) DMBKQSZ MT DTT DMBKQSZ MA Activator DMBKQSZ RN Clinical pipeline report, company report or official report of vTv Therapeutics. DMBKQSZ RU https://vtvtherapeutics.com/pipeline/ttp399/ DMMNTOW DI DMMNTOW DMMNTOW DN TTP435 DMMNTOW MI TT4DE1O DMMNTOW MN Agouti-related protein (AGRP) DMMNTOW MT DTT DMMNTOW MA Inhibitor DMMNTOW RN Clinical pipeline report, company report or official report of TransTech Pharma (2011). DMMNTOW RU http://www.ttpharma.com/ DMR37X8 DI DMR37X8 DMR37X8 DN TTP-448 DMR37X8 MI TTMO9HF DMR37X8 MN Advanced glycosylation end product receptor (AGER) DMR37X8 MT DTT DMR37X8 MA Modulator DMR37X8 RN Receptor for advanced glycation endproduct modulators: a new therapeutic target in Alzheimer's disease. Expert Opin Investig Drugs. 2015 Mar;24(3):393-9. DMR37X8 RU https://pubmed.ncbi.nlm.nih.gov/25586103 DMCQARM DI DMCQARM DMCQARM DN TTP889 DMCQARM MI TTFEZ5Q DMCQARM MN Coagulation factor IX (F9) DMCQARM MT DTT DMCQARM MA Inhibitor DMCQARM RN Partial factor IXa inhibition with TTP889 for prevention of venous thromboembolism: an exploratory study. J Thromb Haemost. 2008 Mar;6(3):457-63. DMCQARM RU https://pubmed.ncbi.nlm.nih.gov/18088349 DMCQARM DI DMCQARM DMCQARM DN TTP889 DMCQARM MI TTUPB12 DMCQARM MN Measles virus Fusion glycoprotein (MeV F) DMCQARM MT DTT DMCQARM MA Inhibitor DMCQARM RN Emerging drugs for respiratory syncytial virus infection. Expert Opin Emerg Drugs. 2009 Jun;14(2):207-17. DMCQARM RU https://pubmed.ncbi.nlm.nih.gov/19453286 DMW7PFS DI DMW7PFS DMW7PFS DN Turosteride DMW7PFS MI TT2A0DR DMW7PFS MN Oxo-5-alpha-steroid 4-dehydrogenase (SRD5A) DMW7PFS MT DTT DMW7PFS MA Inhibitor DMW7PFS RN Hormonal effects of turosteride, a 5 alpha-reductase inhibitor, in the rat. J Steroid Biochem Mol Biol. 1993 Nov;46(5):549-55. DMW7PFS RU https://pubmed.ncbi.nlm.nih.gov/8240976 DM28M6I DI DM28M6I DM28M6I DN TV-1102 DM28M6I MI TT2VIZQ DM28M6I MN ITGAV messenger RNA (ITGAV mRNA) DM28M6I MT DTT DM28M6I RN Design and development of antisense drugs. Expert Opin. Drug Discov. 2008 3(10):1189-1207. DM28M6I RU http://www.informahealthcare.com/doi/abs/10.1517/17460441.3.10.1177 DM19GUH DI DM19GUH DM19GUH DN TVB-2640 DM19GUH MI TT7AOUD DM19GUH MN Fatty acid synthase (FASN) DM19GUH MT DTT DM19GUH MA Inhibitor DM19GUH RN Imidazopyridine-Based Fatty Acid Synthase Inhibitors That Show Anti-HCV Activity and in Vivo Target Modulation. ACS Med Chem Lett. 2013 January 10; 4(1): 113-117. DM19GUH RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4027139/ DMP30SA DI DMP30SA DMP30SA DN TVB-2640 DMP30SA MI TT7AOUD DMP30SA MN Fatty acid synthase (FASN) DMP30SA MT DTT DMP30SA MA Inhibitor DMP30SA RN Fatty Acid Synthase Inhibitor TVB-2640 Reduces Hepatic de Novo Lipogenesis in Males With Metabolic Abnormalities. Hepatology. 2020 Jul;72(1):103-118. DMP30SA RU https://pubmed.ncbi.nlm.nih.gov/31630414 DMGYSZ0 DI DMGYSZ0 DMGYSZ0 DN TVI-Kidney-1 DMGYSZ0 MI TTXQYT6 DMGYSZ0 MN T-cells (T-cells) DMGYSZ0 MT DTT DMGYSZ0 RN Clinical pipeline report, company report or official report of TVAX Biomedical. DMGYSZ0 RU http://www.tvaxbiomedical.com/tvi-kidney.shtml DMKJIDU DI DMKJIDU DMKJIDU DN TZI-41078 DMKJIDU MI TTG3K2U DMKJIDU MN Lipoxygenase (ALOX) DMKJIDU MT DTT DMKJIDU MA Modulator DMKJIDU RN Hydroxylamine analogs of 2,6-di-t-butylphenols: dual inhibitors of cyclooxygenase and 5-lipoxygenase or selective 5-lipoxygenase inhibitors. 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DMWDJ15 RU https://pubmed.ncbi.nlm.nih.gov/2521810 DM2O4MI DI DM2O4MI DM2O4MI DN UK-432097 DM2O4MI MI TTM2AOE DM2O4MI MN Adenosine A2a receptor (ADORA2A) DM2O4MI MT DTT DM2O4MI MA Agonist DM2O4MI RN Structure of an agonist-bound human A2A adenosine receptor. Science. 2011 Apr 15;332(6027):322-7. DM2O4MI RU https://pubmed.ncbi.nlm.nih.gov/21393508 DM8LBUK DI DM8LBUK DM8LBUK DN UNI-PH (1-34) DM8LBUK MI TTEPJL5 DM8LBUK MN Parathyroid hormone receptor (PTH2R) DM8LBUK MT DTT DM8LBUK MA Modulator DM8LBUK RN Parathyroid hormone for the treatment of osteoporosis: a systematic review. CMAJ. 2006 July 4; 175(1): 52-59. DM8LBUK RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1482742/ DMOMI97 DI DMOMI97 DMOMI97 DN UNI-rE-4 DMOMI97 MI TTVIMDE DMOMI97 MN Glucagon-like peptide 1 receptor (GLP1R) DMOMI97 MT DTT DMOMI97 MA Modulator DMOMI97 RN Exenatide and liraglutide: different approaches to develop GLP-1 receptor agonists (incretin mimetics)--preclinical and clinical results. Best Pract Res Clin Endocrinol Metab. 2009 Aug;23(4):463-77. DMOMI97 RU https://pubmed.ncbi.nlm.nih.gov/19748064 DMFZULI DI DMFZULI DMFZULI DN Upamostat DMFZULI MI TTGY7WI DMFZULI MN Urokinase-type plasminogen activator (PLAU) DMFZULI MT DTT DMFZULI MA Inhibitor DMFZULI RN Phase II randomised proof-of-concept study of the urokinase inhibitor upamostat (WX-671) in combination with gemcitabine compared with gemcitabine alone in patients with non-resectable, locally advanced pancreatic cancer. Br J Cancer. 2013 Mar 5;108(4):766-70. DMFZULI RU https://pubmed.ncbi.nlm.nih.gov/23412098 DME6X27 DI DME6X27 DME6X27 DN UR-63325 DME6X27 MI TTXJ178 DME6X27 MN Histamine H4 receptor (H4R) DME6X27 MT DTT DME6X27 MA Antagonist DME6X27 RN Azines as histamine H4 receptor antagonists. Front Biosci (Schol Ed). 2012 Jan 1;4:967-87. 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DMY89BN RU http://www.chugai-pharm.co.jp/english/ir/reports_downloads/pipeline.html DM6RTVG DI DM6RTVG DM6RTVG DN Urelumab DM6RTVG MI TTPW9LJ DM6RTVG MN Co-stimulatory molecule 4-1BB (CD137) DM6RTVG MT DTT DM6RTVG MA Agonist DM6RTVG RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DM6RTVG RU http://phrma-docs.phrma.org/files/dmfile/MID_Immuno-Oncology-2017_Drug-List1.pdf DM0YO4Q DI DM0YO4Q DM0YO4Q DN Urocortin 2 DM0YO4Q MI TTIY658 DM0YO4Q MN Corticotropin-releasing factor receptor 2 (CRHR2) DM0YO4Q MT DTT DM0YO4Q MA Antagonist DM0YO4Q RN Evolution of complementary peptide systems: teneurin C-terminal-associated peptides and corticotropin-releasing factor superfamilies. Ann N Y Acad Sci. 2009 Apr;1163:215-20. DM0YO4Q RU https://pubmed.ncbi.nlm.nih.gov/19456342 DM4SOAW DI DM4SOAW DM4SOAW DN URSOLIC ACID DM4SOAW MI TTN7BL9 DM4SOAW MN Corticosteroid 11-beta-dehydrogenase 1 (HSD11B1) DM4SOAW MT DTT DM4SOAW MA Inhibitor DM4SOAW RN 11beta-Hydroxysteroid dehydrogenase 1 inhibiting constituents from Eriobotrya japonica revealed by bioactivity-guided isolation and computational a... Bioorg Med Chem. 2010 Feb 15;18(4):1507-15. DM4SOAW RU https://pubmed.ncbi.nlm.nih.gov/20100662 DM4SOAW DI DM4SOAW DM4SOAW DN URSOLIC ACID DM4SOAW MI TTZHY6R DM4SOAW MN Glycogen phosphorylase muscle form (GP) DM4SOAW MT DTT DM4SOAW MA Inhibitor DM4SOAW RN Synthesis of 3-deoxypentacyclic triterpene derivatives as inhibitors of glycogen phosphorylase. J Nat Prod. 2009 Aug;72(8):1414-8. DM4SOAW RU https://pubmed.ncbi.nlm.nih.gov/19642687 DM4SOAW DI DM4SOAW DM4SOAW DN URSOLIC ACID DM4SOAW MI TTIU7X1 DM4SOAW MN Herpes simplex virus DNA polymerase UL30 (HSV UL30) DM4SOAW MT DTT DM4SOAW MA Inhibitor DM4SOAW RN DNA polymerase beta inhibitors from Baeckea gunniana. J Nat Prod. 1999 Dec;62(12):1624-6. DM4SOAW RU https://pubmed.ncbi.nlm.nih.gov/10654412 DM4SOAW DI DM4SOAW DM4SOAW DN URSOLIC ACID DM4SOAW MI TT9V5JH DM4SOAW MN Phospholipase A2 (PLA2G1B) DM4SOAW MT DTT DM4SOAW MA Inhibitor DM4SOAW RN Synthesis of benzoyl phenyl benzoates as effective inhibitors for phospholipase A2 and hyaluronidase enzymes. Bioorg Med Chem Lett. 2005 Sep 15;15(18):4100-4. DM4SOAW RU https://pubmed.ncbi.nlm.nih.gov/15993585 DM4SOAW DI DM4SOAW DM4SOAW DN URSOLIC ACID DM4SOAW MI TTELIN2 DM4SOAW MN PTPN1 messenger RNA (PTPN1 mRNA) DM4SOAW MT DTT DM4SOAW MA Inhibitor DM4SOAW RN Cytotoxic and PTP1B inhibitory activities from Erythrina abyssinica. Bioorg Med Chem Lett. 2009 Dec 1;19(23):6745-9. DM4SOAW RU https://pubmed.ncbi.nlm.nih.gov/19836230 DMDPFTB DI DMDPFTB DMDPFTB DN V-101 DMDPFTB MI TT2NUT5 DMDPFTB MN Adrenergic receptor alpha-2C (ADRA2C) DMDPFTB MT DTT DMDPFTB MA Agonist DMDPFTB RN Rosacea: update on management and emerging therapies. Skin Therapy Lett. 2012 Dec;17(10):1-4. DMDPFTB RU https://pubmed.ncbi.nlm.nih.gov/23223767 DM1ODP6 DI DM1ODP6 DM1ODP6 DN VA-106483 DM1ODP6 MI TTK8R02 DM1ODP6 MN Vasopressin V2 receptor (V2R) DM1ODP6 MT DTT DM1ODP6 MA Inhibitor DM1ODP6 RN New benzylureas as a novel series of potent, nonpeptidic vasopressin V2 receptor agonists. J Med Chem. 2008 Dec 25;51(24):8124-34. DM1ODP6 RU https://pubmed.ncbi.nlm.nih.gov/19053774 DMAYWXD DI DMAYWXD DMAYWXD DN VA-111913 DMAYWXD MI TT4TFGN DMAYWXD MN Vasopressin V1a receptor (V1AR) DMAYWXD MT DTT DMAYWXD MA Antagonist DMAYWXD RN Clinical pipeline report, company report or official report of Avarx. DMAYWXD RU http://www.avarx.com/AvaRx/SubDomains/bucket304f365f4d5c821c892abf2b5eb4/Listings/bucket3e0f28b94cc197c9e1c49f1451ad/Public.Listing.display.html DM9GZW6 DI DM9GZW6 DM9GZW6 DN Vabicaserin DM9GZW6 MI TT0K1SC DM9GZW6 MN 5-HT 2B receptor (HTR2B) DM9GZW6 MT DTT DM9GZW6 MA Modulator DM9GZW6 RN Prediction of Efficacy of Vabicaserin, a 5-HT2C Agonist, for the Treatment of Schizophrenia Using a Quantitative Systems Pharmacology Model.CPT Pharmacometrics Syst Pharmacol.2014 Apr 23;3:e111. DM9GZW6 RU https://www.ncbi.nlm.nih.gov/pubmed/24759548 DM9GZW6 DI DM9GZW6 DM9GZW6 DN Vabicaserin DM9GZW6 MI TTWJBZ5 DM9GZW6 MN 5-HT 2C receptor (HTR2C) DM9GZW6 MT DTT DM9GZW6 MA Modulator DM9GZW6 RN Prediction of Efficacy of Vabicaserin, a 5-HT2C Agonist, for the Treatment of Schizophrenia Using a Quantitative Systems Pharmacology Model.CPT Pharmacometrics Syst Pharmacol.2014 Apr 23;3:e111. DM9GZW6 RU https://www.ncbi.nlm.nih.gov/pubmed/24759548 DMDAKZW DI DMDAKZW DMDAKZW DN Vacc-4x DMDAKZW MI TTTWS2G DMDAKZW MN Human immunodeficiency virus Capsid p24 (HIV p24) DMDAKZW MT DTT DMDAKZW RN Clinical pipeline report, company report or official report of Bionor Pharma. DMDAKZW RU http://www.bionorpharma.com/en/News/2011/Scientific/Vacc-4x+results+presented+in+Bangkok.b7C_wljS1c.ips DMK7CYX DI DMK7CYX DMK7CYX DN Vadimezan DMK7CYX MI DEJGDUW DMK7CYX MN Cytochrome P450 1A2 (CYP1A2) DMK7CYX MT DME DMK7CYX MA Metabolism DMK7CYX RN Preclinical factors affecting the interindividual variability in the clearance of the investigational anti-cancer drug 5,6-dimethylxanthenone-4-acetic acid. Biochem Pharmacol. 2003 Jun 1;65(11):1853-65. DMK7CYX RU https://www.ncbi.nlm.nih.gov/pubmed/?term=12781337 DMK7CYX DI DMK7CYX DMK7CYX DN Vadimezan DMK7CYX MI TTSXVID DMK7CYX MN Nuclear factor NF-kappa-B (NFKB) DMK7CYX MT DTT DMK7CYX MA Modulator DMK7CYX RN Auckland Cancer Society Research Centre report DMK7CYX RU https://www.fmhs.auckland.ac.nz/en/sms/about/our-departments/oncology/cancer-trials-nz/trials-and-research-projects/closed/asa404.html DMK7CYX DI DMK7CYX DMK7CYX DN Vadimezan DMK7CYX MI DE85D2P DMK7CYX MN UDP-glucuronosyltransferase 1A9 (UGT1A9) DMK7CYX MT DME DMK7CYX MA Metabolism DMK7CYX RN Predicting pharmacokinetics and drug interactions in patients from in vitro and in vivo models: the experience with 5,6-dimethylxanthenone-4-acetic acid (DMXAA), an anti-cancer drug eliminated mainly by conjugation. Drug Metab Rev. 2002 Nov;34(4):751-90. 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DMFWZ2U RU https://pubmed.ncbi.nlm.nih.gov/17328231 DMCF5E0 DI DMCF5E0 DMCF5E0 DN Vaniprevir DMCF5E0 MI TT5FNQT DMCF5E0 MN Human immunodeficiency virus Protease (HIV PR) DMCF5E0 MT DTT DMCF5E0 MA Inhibitor DMCF5E0 RN Clinical pipeline report, company report or official report of Merck (2011). DMCF5E0 RU http://www.merck.com/index.html DMNFVKC DI DMNFVKC DMNFVKC DN Vapitadine DMNFVKC MI TTTIBOJ DMNFVKC MN Histamine H1 receptor (H1R) DMNFVKC MT DTT DMNFVKC MA Antagonist DMNFVKC RN Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800020866) DMNFVKC RU http://adisinsight.springer.com/drugs/800020866 DMQSC5O DI DMQSC5O DMQSC5O DN Varlilumab DMQSC5O MI TTDO1MV DMQSC5O MN T-cell activation antigen CD27 (CD27) DMQSC5O MT DTT DMQSC5O MA Inhibitor DMQSC5O RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMQSC5O RU http://phrma-docs.phrma.org/files/dmfile/MID_Immuno-Oncology-2017_Drug-List1.pdf DMKU93J DI DMKU93J DMKU93J DN VAS-203 DMKU93J MI TTCM4B3 DMKU93J MN Nitric-oxide synthase endothelial (NOS3) DMKU93J MT DTT DMKU93J MA Inhibitor DMKU93J RN Nitric oxide synthase inhibition with the antipterin VAS203 improves outcome in moderate and severe traumatic brain injury: a placebo-controlled randomized Phase IIa trial (NOSTRA). J Neurotrauma. 2014 Oct 1;31(19):1599-606. DMKU93J RU https://pubmed.ncbi.nlm.nih.gov/24831445 DMRJ5LP DI DMRJ5LP DMRJ5LP DN Vasoactive intestinal peptide DMRJ5LP MI TTCL30I DMRJ5LP MN Vasoactive intestinal polypeptide receptor 1 (VIPR1) DMRJ5LP MT DTT DMRJ5LP MA Antagonist DMRJ5LP RN Emerging treatments for pulmonary arterial hypertension. Expert Opin Emerg Drugs. 2006 Nov;11(4):609-19. DMRJ5LP RU https://pubmed.ncbi.nlm.nih.gov/17064221 DMY0UEQ DI DMY0UEQ DMY0UEQ DN VATALANIB DMY0UEQ MI TTGKNB4 DMY0UEQ MN Epidermal growth factor receptor (EGFR) DMY0UEQ MT DTT DMY0UEQ MA Inhibitor DMY0UEQ RN Dual irreversible kinase inhibitors: quinazoline-based inhibitors incorporating two independent reactive centers with each targeting different cyst... Bioorg Med Chem. 2007 Jun 1;15(11):3635-48. DMY0UEQ RU https://pubmed.ncbi.nlm.nih.gov/17416531 DMY0UEQ DI DMY0UEQ DMY0UEQ DN VATALANIB DMY0UEQ MI TTUTJGQ DMY0UEQ MN Vascular endothelial growth factor receptor 2 (KDR) DMY0UEQ MT DTT DMY0UEQ MA Inhibitor DMY0UEQ RN Dual irreversible kinase inhibitors: quinazoline-based inhibitors incorporating two independent reactive centers with each targeting different cyst... Bioorg Med Chem. 2007 Jun 1;15(11):3635-48. DMY0UEQ RU https://pubmed.ncbi.nlm.nih.gov/17416531 DMY0UEQ DI DMY0UEQ DMY0UEQ DN VATALANIB DMY0UEQ MI TTDCBX5 DMY0UEQ MN Vascular endothelial growth factor receptor 3 (FLT-4) DMY0UEQ MT DTT DMY0UEQ MA Inhibitor DMY0UEQ RN Discovery and evaluation of 2-anilino-5-aryloxazoles as a novel class of VEGFR2 kinase inhibitors. J Med Chem. 2005 Mar 10;48(5):1610-9. DMY0UEQ RU https://pubmed.ncbi.nlm.nih.gov/15743202 DMY0UEQ DI DMY0UEQ DMY0UEQ DN VATALANIB DMY0UEQ MI TT1VAUK DMY0UEQ MN VEGFR1 messenger RNA (VEGFR1 mRNA) DMY0UEQ MT DTT DMY0UEQ MA Inhibitor DMY0UEQ RN Inhibitors of VEGF receptors-1 and -2 based on the 2-((pyridin-4-yl)ethyl)pyridine template. Bioorg Med Chem Lett. 2006 Apr 1;16(7):1913-9. DMY0UEQ RU https://pubmed.ncbi.nlm.nih.gov/16460936 DM3V7QO DI DM3V7QO DM3V7QO DN Vatelizumab DM3V7QO MI TTMSB0A DM3V7QO MN Integrin alpha-2/beta-1 (ITGA2/B1) DM3V7QO MT DTT DM3V7QO RN Sulfonamide inhibitors of alpha2beta1 integrin reveal the essential role of collagen receptors in in vivo models of inflammation. Pharmacol Res Perspect. 2015 June; 3(3): e00146. DM3V7QO RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4492762/ DML2CPW DI DML2CPW DML2CPW DN VAY736 DML2CPW MI TT7NJSE DML2CPW MN B-cell-activating factor receptor (TNFRSF13C) DML2CPW MT DTT DML2CPW RN National Cancer Institute Drug Dictionary (drug id 762784). DML2CPW RU http://www.cancer.gov/publications/dictionaries/cancer-drug?cdrid=762784 DM0YWQ4 DI DM0YWQ4 DM0YWQ4 DN VB 1953 DM0YWQ4 MI TTN6J5F DM0YWQ4 MN Bacterial DNA gyrase (Bact gyrase) DM0YWQ4 MT DTT DM0YWQ4 MA Inhibitor DM0YWQ4 RN Clinical pipeline report, company report or official report of Vyome Therapeutics. DM0YWQ4 RU https://www.vyometx.com/platform-strategy.html DM0YWQ4 DI DM0YWQ4 DM0YWQ4 DN VB 1953 DM0YWQ4 MI TTFK8YB DM0YWQ4 MN Bacterial DNA topoisomerase 4A (Bact parC) DM0YWQ4 MT DTT DM0YWQ4 MA Inhibitor DM0YWQ4 RN Clinical pipeline report, company report or official report of Vyome Therapeutics. DM0YWQ4 RU https://www.vyometx.com/platform-strategy.html DM047HI DI DM047HI DM047HI DN VBP15 DM047HI MI TTOZRK6 DM047HI MN Glucocorticoid receptor messenger RNA (GCR mRNA) DM047HI MT DTT DM047HI MA Agonist DM047HI RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DM047HI RU http://phrma-docs.phrma.org/files/dmfile/medicines-in-development-drug-list-autoimmune-diseases.pdf DMAJ85O DI DMAJ85O DMAJ85O DN VDA-1102 DMAJ85O MI TTK02H8 DMAJ85O MN Hexokinase-2 (HK2) DMAJ85O MT DTT DMAJ85O MA Modulator DMAJ85O RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMAJ85O RU http://phrma-docs.phrma.org/files/dmfile/MID_Skin_Diseases_2018_9_FINAL.pdf DME6I03 DI DME6I03 DME6I03 DN VDA-1102 DME6I03 MI TTJLNAW DME6I03 MN Tissue kallikrein (KLK2) DME6I03 MT DTT DME6I03 MA Modulator DME6I03 RN Clinical pipeline report, company report or official report of Vidac Pharma. DME6I03 RU http://www.vidacpharma.com/vda-1102-iv-vidac-pharma DME6I03 DI DME6I03 DME6I03 DN VDA-1102 DME6I03 MI TTPZI04 DME6I03 MN Voltage-dependent anion channel (VDAC) DME6I03 MT DTT DME6I03 MA Modulator DME6I03 RN Clinical pipeline report, company report or official report of Vidac Pharma. DME6I03 RU http://www.vidacpharma.com/vda-1102-iv-vidac-pharma DMAJ85O DI DMAJ85O DMAJ85O DN VDA-1102 DMAJ85O MI TTAMKGB DMAJ85O MN Voltage-dependent anion-selective channel 1 (VDAC1) DMAJ85O MT DTT DMAJ85O MA Modulator DMAJ85O RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMAJ85O RU http://phrma-docs.phrma.org/files/dmfile/MID_Skin_Diseases_2018_9_FINAL.pdf DM5BL4C DI DM5BL4C DM5BL4C DN Veltuzumab DM5BL4C MI TTUE541 DM5BL4C MN Leukocyte surface antigen Leu-16 (CD20) DM5BL4C MT DTT DM5BL4C MA Modulator DM5BL4C RN Veltuzumab, an anti-CD20 mAb for the treatment of non-Hodgkin's lymphoma, chronic lymphocytic leukemia and immune thrombocytopenic purpura. Curr Opin Mol Ther. 2009 Apr;11(2):200-7. DM5BL4C RU https://pubmed.ncbi.nlm.nih.gov/19330725 DMLPEZS DI DMLPEZS DMLPEZS DN Venglustat DMLPEZS MI TTPHEX3 DMLPEZS MN Ceramide glucosyltransferase (UGCG) DMLPEZS MT DTT DMLPEZS MA Inhibitor DMLPEZS RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMLPEZS RU http://phrma-docs.phrma.org/files/dmfile/MID_Neurological-Disorders-Drug-List_2018.pdf DMFLZPC DI DMFLZPC DMFLZPC DN VER 50589 DMFLZPC MI TT78R5H DMFLZPC MN Heat shock protein 90 alpha (HSP90A) DMFLZPC MT DTT DMFLZPC MA Inhibitor DMFLZPC RN Recent advances in Hsp90 inhibitors as antitumor agents. Anticancer Agents Med Chem. 2008 Oct;8(7):761-82. DMFLZPC RU https://pubmed.ncbi.nlm.nih.gov/18855578 DM104SP DI DM104SP DM104SP DN Vericigiuat DM104SP MI TTLBYH1 DM104SP MN Guanylate cyclase soluble beta-1 (GUCY1B1) DM104SP MT DTT DM104SP MA Modulator DM104SP RN Rationale and design of the SOluble guanylate Cyclase stimulatoR in heArT failurE Studies (SOCRATES). Eur J Heart Fail. 2014 Sep;16(9):1026-38. DM104SP RU https://pubmed.ncbi.nlm.nih.gov/25056511 DMBQC3L DI DMBQC3L DMBQC3L DN Verubulin DMBQC3L MI TTYFKSZ DMBQC3L MN Tubulin beta (TUBB) DMBQC3L MT DTT DMBQC3L MA Modulator DMBQC3L RN Effects of the tumor-vasculature-disrupting agent verubulin and two heteroaryl analogues on cancer cells, endothelial cells, and blood vessels.ChemMedChem.2014 Apr;9(4):847-54. DMBQC3L RU https://www.ncbi.nlm.nih.gov/pubmed/24678059 DM0POWG DI DM0POWG DM0POWG DN Vidofludimus DM0POWG MI TTLVP78 DM0POWG MN Dihydroorotate dehydrogenase (DHODH) DM0POWG MT DTT DM0POWG MA Modulator DM0POWG RN Company report (4SC) DM0POWG RU http://www.4sc.de/product-pipeline/clinical/vidofludimus DME7VZD DI DME7VZD DME7VZD DN Vilaprisan DME7VZD MI DE4LYSA DME7VZD MN Cytochrome P450 3A4 (CYP3A4) DME7VZD MT DME DME7VZD MA Metabolism DME7VZD RN Characterization of the pharmacokinetics of vilaprisan: bioavailability, excretion, biotransformation, and drug-drug interaction potential. Clin Pharmacokinet. 2018 Aug;57(8):1001-1015. DME7VZD RU https://www.ncbi.nlm.nih.gov/pubmed/?term=29330782 DME7VZD DI DME7VZD DME7VZD DN Vilaprisan DME7VZD MI TTUV8G9 DME7VZD MN Progesterone receptor (PGR) DME7VZD MT DTT DME7VZD MA Antagonist DME7VZD RN Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800033939) DME7VZD RU http://adisinsight.springer.com/drugs/800033939 DME7VZD DI DME7VZD DME7VZD DN Vilaprisan DME7VZD MI DE4G629 DME7VZD MN Succinic semialdehyde reductase (AKR7A2) DME7VZD MT DME DME7VZD MA Metabolism DME7VZD RN Characterization of the pharmacokinetics of vilaprisan: bioavailability, excretion, biotransformation, and drug-drug interaction potential. Clin Pharmacokinet. 2018 Aug;57(8):1001-1015. DME7VZD RU https://www.ncbi.nlm.nih.gov/pubmed/?term=29330782 DM2X0SP DI DM2X0SP DM2X0SP DN VIR-2218 DM2X0SP MI TTINUYD DM2X0SP MN Hepatitis B virus Large envelope protein (HBV S) DM2X0SP MT DTT DM2X0SP MA Inhibitor DM2X0SP RN Clinical pipeline report, company report or official report of Vir Biotechnology. DM2X0SP RU https://www.vir.bio/pipeline/ DMEXMV5 DI DMEXMV5 DMEXMV5 DN Virexxa DMEXMV5 MI TTUV8G9 DMEXMV5 MN Progesterone receptor (PGR) DMEXMV5 MT DTT DMEXMV5 MA Inducer DMEXMV5 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 627). DMEXMV5 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=627 DM1G6ME DI DM1G6ME DM1G6ME DN VIS410 DM1G6ME MI TTF4CAM DM1G6ME MN Influenza Hemagglutinin (Influ HA) DM1G6ME MT DTT DM1G6ME MA Inhibitor DM1G6ME RN Clinical pipeline report, company report or official report of Visterra. DM1G6ME RU http://www.visterrainc.com/#pipeline DMY5NUR DI DMY5NUR DMY5NUR DN VK-2809 DMY5NUR MI TTGER3L DMY5NUR MN Thyroid hormone receptor beta (THRB) DMY5NUR MT DTT DMY5NUR MA Agonist DMY5NUR RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMY5NUR RU http://phrma-docs.phrma.org/files/dmfile/2018_Heart-Disease-and-Stroke_MID-Drug-List.pdf DMLT94F DI DMLT94F DMLT94F DN VLS-101 DMLT94F MI TTDEJAU DMLT94F MN Neurotrophic tyrosine kinase ROR1 (ROR1) DMLT94F MT DTT DMLT94F RN Clinical pipeline report, company report or official report of VelosBio. DMLT94F RU https://velosbio.com/our-science/pipeline DM4O17U DI DM4O17U DM4O17U DN VLTS-589 DM4O17U MI TT69TQN DM4O17U MN Integrin alpha-V/beta-3 (ITGAV/B3) DM4O17U MT DTT DM4O17U MA Modulator DM4O17U RN AbbVie Licenses Phase II-Ready Antibody Programme to Receptos for Development in Eosinophilic Oesophagitis. 2013(4), Page 35. DM4O17U RU http://ojs.pharmadeals.net:5555/index.php/pdr/article/view/cr1914/html DM9KNJT DI DM9KNJT DM9KNJT DN Vobarilizumab DM9KNJT MI TT0E5SK DM9KNJT MN Interleukin 6 receptor (IL6R) DM9KNJT MT DTT DM9KNJT MA Inhibitor DM9KNJT RN Clinical pipeline report, company report or official report of Ablynx. DM9KNJT RU https://www.ablynx.com/uploads/data/files/160706%20alx-0061%20c202%20webcast_final.pdf DM9KNJT DI DM9KNJT DM9KNJT DN Vobarilizumab DM9KNJT MI TTFNGC9 DM9KNJT MN Serum albumin (ALB) DM9KNJT MT DTT DM9KNJT MA Inhibitor DM9KNJT RN Clinical pipeline report, company report or official report of Ablynx. DM9KNJT RU https://www.ablynx.com/uploads/data/files/160706%20alx-0061%20c202%20webcast_final.pdf DMQMYP5 DI DMQMYP5 DMQMYP5 DN VOFOPITANT HYDROCHLORIDE DMQMYP5 MI TTZPO1L DMQMYP5 MN Substance-P receptor (TACR1) DMQMYP5 MT DTT DMQMYP5 MA Antagonist DMQMYP5 RN Efficacy and safety of casopitant mesylate, a neurokinin 1 (NK1)-receptor antagonist, in prevention of chemotherapy-induced nausea and vomiting in patients receiving cisplatin-based highly emetogenicchemotherapy: a randomised, double-blind, placebo-controlled trial. Lancet Oncol. 2009 Jun;10(6):549-58. DMQMYP5 RU https://pubmed.ncbi.nlm.nih.gov/19428297 DMNQG24 DI DMNQG24 DMNQG24 DN Volociximab DMNQG24 MI TTH4QIS DMNQG24 MN Integrin alpha-5/beta-1 (ITGA5/B1) DMNQG24 MT DTT DMNQG24 RN Preclinical evaluation of an anti-alpha5beta1 integrin antibody as a novel anti-angiogenic agent. J Exp Ther Oncol. 2006;5(4):273-86. DMNQG24 RU https://pubmed.ncbi.nlm.nih.gov/17024968 DMIM1U9 DI DMIM1U9 DMIM1U9 DN Vorolanib DMIM1U9 MI TTI2WET DMIM1U9 MN Platelet-derived growth factor receptor (PDGFR) DMIM1U9 MT DTT DMIM1U9 MA Inhibitor DMIM1U9 RN Vorolanib, an oral VEGFR/PDGFR dual tyrosine kinase inhibitor for treatment of patients with advanced solid tumors: An open-label, phase I dose escalation and dose expansion trial. Chin J Cancer Res. 2021 Feb 28;33(1):103-114. DMIM1U9 RU https://pubmed.ncbi.nlm.nih.gov/33707933 DMIM1U9 DI DMIM1U9 DMIM1U9 DN Vorolanib DMIM1U9 MI TTVJ1D8 DMIM1U9 MN Vascular endothelial growth factor receptor (VEGFR) DMIM1U9 MT DTT DMIM1U9 MA Inhibitor DMIM1U9 RN Vorolanib, an oral VEGFR/PDGFR dual tyrosine kinase inhibitor for treatment of patients with advanced solid tumors: An open-label, phase I dose escalation and dose expansion trial. Chin J Cancer Res. 2021 Feb 28;33(1):103-114. DMIM1U9 RU https://pubmed.ncbi.nlm.nih.gov/33707933 DMW4LTI DI DMW4LTI DMW4LTI DN Votucalis DMW4LTI MI TT7CXIM DMW4LTI MN Histamine receptor (HR) DMW4LTI MT DTT DMW4LTI MA Antagonist DMW4LTI RN CA patent application no. 520580, Histamine binding compounds for treatment method for disease conditions mediated by neutrophils. DMW4LTI RU http://www.google.com.ar/patents/CA2520580A1?cl=en DMUQZT4 DI DMUQZT4 DMUQZT4 DN VPI-2690B DMUQZT4 MI TTHRID2 DMUQZT4 MN Insulin-like growth factor I receptor (IGF1R) DMUQZT4 MT DTT DMUQZT4 MA Antagonist DMUQZT4 RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMUQZT4 RU http://phrma-docs.phrma.org/files/dmfile/mid-diabetes-drug-list.pdf DMHET8R DI DMHET8R DMHET8R DN VRC-HIVDNA016-00-VP DMHET8R MI TTUIFO6 DMHET8R MN Human immunodeficiency virus Adenovector Ad35 (HIV Ad35) DMHET8R MT DTT DMHET8R RN ClinicalTrials.gov (NCT00123968) Safety of and Immune Response to an HIV-1 Vaccine (VRC-HIVDNA016-00-VP) and a Vaccine Booster (VRC-HIVADV014-00-VP) in HIV Uninfected East African Adults. U.S. National Institutes of Health. DMHET8R RU https://clinicaltrials.gov/ct2/show/NCT00123968 DMGBLI3 DI DMGBLI3 DMGBLI3 DN VS-6063 DMGBLI3 MI TTON5IT DMGBLI3 MN Focal adhesion kinase 1 (FAK) DMGBLI3 MT DTT DMGBLI3 MA Inhibitor DMGBLI3 RN Role of focal adhesion kinase in regulating YB-1-mediated paclitaxel resistance in ovarian cancer. J Natl Cancer Inst. 2013 Oct 2;105(19):1485-95. DMGBLI3 RU https://pubmed.ncbi.nlm.nih.gov/24062525 DMY9ZGN DI DMY9ZGN DMY9ZGN DN VT-111a DMY9ZGN MI TTEMV5X DMY9ZGN MN Serine protease unspecific (SP) DMY9ZGN MT DTT DMY9ZGN MA Modulator DMY9ZGN RN Viral Serpin Therapeutics: From Concept to Clinic. Methods Enzymol. 2011; 499: 301-329. DMY9ZGN RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3558843/ DMCGK9H DI DMCGK9H DMCGK9H DN VT-1129 DMCGK9H MI TT3C1VN DMCGK9H MN Enzyme unspecific (Enz) DMCGK9H MT DTT DMCGK9H MA Inhibitor DMCGK9H RN The clinical candidate VT-1161 is a highly potent inhibitor of Candida albicans CYP51 but fails to bind the human enzyme. Antimicrob Agents Chemother. 2014 Dec;58(12):7121-7. DMCGK9H RU https://pubmed.ncbi.nlm.nih.gov/25224009 DMCGK9H DI DMCGK9H DMCGK9H DN VT-1129 DMCGK9H MI TT67TDP DMCGK9H MN Lanosterol 14-alpha demethylase (CYP51A1) DMCGK9H MT DTT DMCGK9H MA Inhibitor DMCGK9H RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMCGK9H RU http://phrma-docs.phrma.org/files/dmfile/MID_Skin_Diseases_2018_9_FINAL.pdf DMNY3J0 DI DMNY3J0 DMNY3J0 DN VTB-38543 DMNY3J0 MI TTXA6PH DMNY3J0 MN Oxysterols receptor LXR-beta (NR1H2) DMNY3J0 MT DTT DMNY3J0 MA Agonist DMNY3J0 RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMNY3J0 RU http://phrma-docs.phrma.org/files/dmfile/MID_Skin_Diseases_2018_9_FINAL.pdf DMCA8G1 DI DMCA8G1 DMCA8G1 DN VTP-43742 DMCA8G1 MI TTGV6LY DMCA8G1 MN Nuclear receptor ROR-gamma (RORG) DMCA8G1 MT DTT DMCA8G1 MA Inhibitor DMCA8G1 RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMCA8G1 RU http://phrma-docs.phrma.org/files/dmfile/medicines-in-development-drug-list-autoimmune-diseases.pdf DMN6J18 DI DMN6J18 DMN6J18 DN Vupanorsen DMN6J18 MI TT59GO7 DMN6J18 MN ANGPTL3 messenger RNA (ANGPTL3 mRNA) DMN6J18 MT DTT DMN6J18 MA Inhibitor DMN6J18 RN Clinical pipeline report, company report or official report of Ionis Pharmaceuticals. DMN6J18 RU https://www.ionispharma.com/ionis-innovation/pipeline/ DM6BKG2 DI DM6BKG2 DM6BKG2 DN VVP-808 DM6BKG2 MI TTCBFJO DM6BKG2 MN Insulin receptor (INSR) DM6BKG2 MT DTT DM6BKG2 MA Modulator DM6BKG2 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1800). DM6BKG2 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1800 DMDKWA3 DI DMDKWA3 DMDKWA3 DN Vx-001 DMDKWA3 MI TTUJFD0 DMDKWA3 MN Telomerase reverse transcriptase (TERT) DMDKWA3 MT DTT DMDKWA3 RN Clinical pipeline report, company report or official report of Vaxon-biotech. DMDKWA3 RU http://vaxon-biotech.com/ DMZ3FE8 DI DMZ3FE8 DMZ3FE8 DN VX-135 DMZ3FE8 MI TTMVBWH DMZ3FE8 MN Hepatitis C virus RNA-directed RNA polymerase (HCV NS5B) DMZ3FE8 MT DTT DMZ3FE8 MA Inhibitor DMZ3FE8 RN All-oral HCV therapies near approval. Nat Rev Drug Discov. 2013 Jun;12(6):409-11. DMZ3FE8 RU https://pubmed.ncbi.nlm.nih.gov/23722330 DMLWM4G DI DMLWM4G DMLWM4G DN VX-15 DMLWM4G MI TT5TKPM DMLWM4G MN Neutral endopeptidase (MME) DMLWM4G MT DTT DMLWM4G MA Inhibitor DMLWM4G RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMLWM4G RU http://phrma-docs.phrma.org/files/dmfile/MID_Immuno-Oncology-2017_Drug-List1.pdf DMLWM4G DI DMLWM4G DMLWM4G DN VX-15 DMLWM4G MI TT5UT28 DMLWM4G MN Semaphorin-4D (SEMA4D) DMLWM4G MT DTT DMLWM4G RN Safety, Pharmacokinetics, and Pharmacodynamics of a Humanized Anti-Semaphorin 4D Antibody, in a First-In-Human Study of Patients with Advanced Soli... Clin Cancer Res. 2016 Feb 15;22(4):827-36. DMLWM4G RU https://pubmed.ncbi.nlm.nih.gov/26446947 DMGDB21 DI DMGDB21 DMGDB21 DN VX-150 DMGDB21 MI TT90XZ8 DMGDB21 MN Voltage-gated sodium channel alpha Nav1.8 (SCN10A) DMGDB21 MT DTT DMGDB21 MA Inhibitor DMGDB21 RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMGDB21 RU http://phrma-docs.phrma.org/files/dmfile/MID_Neurological-Disorders-Drug-List_2018.pdf DMO3U4W DI DMO3U4W DMO3U4W DN VX-222 DMO3U4W MI TTMVBWH DMO3U4W MN Hepatitis C virus RNA-directed RNA polymerase (HCV NS5B) DMO3U4W MT DTT DMO3U4W MA Inhibitor DMO3U4W RN 2011 Pipeline of Vertex. DMO3U4W RU http://www.vrtx.com/current-projects.html DMSTHG1 DI DMSTHG1 DMSTHG1 DN VX-371 DMSTHG1 MI TTQM7TE DMSTHG1 MN Amiloride-sensitive sodium channel (ENaC) DMSTHG1 MT DTT DMSTHG1 MA Inhibitor DMSTHG1 RN The in vitro effect of nebulised hypertonic saline on human bronchial epithelium. Eur Respir J. 2018 May 17;51(5):1702652. DMSTHG1 RU https://pubmed.ncbi.nlm.nih.gov/29599187 DM93YKJ DI DM93YKJ DM93YKJ DN VX-680 DM93YKJ MI TTPS3C0 DM93YKJ MN Aurora kinase A (AURKA) DM93YKJ MT DTT DM93YKJ MA Inhibitor DM93YKJ RN A comparison of physicochemical property profiles of marketed oral drugs and orally bioavailable anti-cancer protein kinase inhibitors in clinical development. Curr Top Med Chem. 2007;7(14):1408-22. DM93YKJ RU https://pubmed.ncbi.nlm.nih.gov/17692029 DM93YKJ DI DM93YKJ DM93YKJ DN VX-680 DM93YKJ MI TT5LS6T DM93YKJ MN Aurora kinase B (AURKB) DM93YKJ MT DTT DM93YKJ MA Inhibitor DM93YKJ RN A comparison of physicochemical property profiles of marketed oral drugs and orally bioavailable anti-cancer protein kinase inhibitors in clinical development. Curr Top Med Chem. 2007;7(14):1408-22. DM93YKJ RU https://pubmed.ncbi.nlm.nih.gov/17692029 DM93YKJ DI DM93YKJ DM93YKJ DN VX-680 DM93YKJ MI TT860QF DM93YKJ MN LCK tyrosine protein kinase (LCK) DM93YKJ MT DTT DM93YKJ MA Inhibitor DM93YKJ RN A comparison of physicochemical property profiles of marketed oral drugs and orally bioavailable anti-cancer protein kinase inhibitors in clinical development. Curr Top Med Chem. 2007;7(14):1408-22. DM93YKJ RU https://pubmed.ncbi.nlm.nih.gov/17692029 DMJAEG6 DI DMJAEG6 DMJAEG6 DN VX-745 DMJAEG6 MI TTYT93M DMJAEG6 MN MAP kinase p38 (MAPK12) DMJAEG6 MT DTT DMJAEG6 MA Inhibitor DMJAEG6 RN P38 MAP kinase inhibitors as potential therapeutics for the treatment of joint degeneration and pain associated with osteoarthritis. J Inflamm (Lond). 2008 Dec 4;5:22. DMJAEG6 RU https://pubmed.ncbi.nlm.nih.gov/19055838 DMJAEG6 DI DMJAEG6 DMJAEG6 DN VX-745 DMJAEG6 MI TTQBR95 DMJAEG6 MN Stress-activated protein kinase 2a (p38 alpha) DMJAEG6 MT DTT DMJAEG6 MA Inhibitor DMJAEG6 RN Pharmacological inhibitors of MAPK pathways. Trends Pharmacol Sci. 2002 Jan;23(1):40-5. DMJAEG6 RU https://pubmed.ncbi.nlm.nih.gov/11804650 DMJAEG6 DI DMJAEG6 DMJAEG6 DN VX-745 DMJAEG6 MI TT73U6C DMJAEG6 MN Stress-activated protein kinase 2b (p38 beta) DMJAEG6 MT DTT DMJAEG6 MA Inhibitor DMJAEG6 RN Pharmacological inhibitors of MAPK pathways. Trends Pharmacol Sci. 2002 Jan;23(1):40-5. DMJAEG6 RU https://pubmed.ncbi.nlm.nih.gov/11804650 DMJUSM8 DI DMJUSM8 DMJUSM8 DN VX-759 DMJUSM8 MI TTMVBWH DMJUSM8 MN Hepatitis C virus RNA-directed RNA polymerase (HCV NS5B) DMJUSM8 MT DTT DMJUSM8 MA Inhibitor DMJUSM8 RN 2011 Pipeline of Vertex. DMJUSM8 RU http://www.vrtx.com/current-projects.html DME321B DI DME321B DME321B DN VX-944 DME321B MI TTCAQMW DME321B MN Inosine-5'-monophosphate dehydrogenase (IMPDH) DME321B MT DTT DME321B MA Inhibitor DME321B RN Novel inosine monophosphate dehydrogenase inhibitor VX-944 induces apoptosis in multiple myeloma cells primarily via caspase-independent AIF/Endo G pathway. Oncogene. 2005 Sep 1;24(38):5888-96. DME321B RU https://pubmed.ncbi.nlm.nih.gov/15940263 DME321B DI DME321B DME321B DN VX-944 DME321B MI TTL7C8Q DME321B MN Inosine-5'-monophosphate dehydrogenase 1 (IMPDH1) DME321B MT DTT DME321B MA Inhibitor DME321B RN Inosine-5'-monophosphate dehydrogenase (IMPDH) inhibitors: a patent and scientific literature review (2002-2016).Expert Opin Ther Pat. 2017 Jun;27(6):677-690. DME321B RU https://www.ncbi.nlm.nih.gov/pubmed/28074661 DMPSBTL DI DMPSBTL DMPSBTL DN VY-AADC DMPSBTL MI TTN451K DMPSBTL MN Aromatic-L-amino-acid decarboxylase (DDC) DMPSBTL MT DTT DMPSBTL MA Replacement DMPSBTL RN Clinical pipeline report, company report or official report of Voyager Therapeutics. DMPSBTL RU https://www.voyagertherapeutics.com/our-approach-programs/clinical-trials/ DMH6XJG DI DMH6XJG DMH6XJG DN WCK-2349 DMH6XJG MI TTIXTO3 DMH6XJG MN Staphylococcus Topoisomerase IV (Stap-coc parC) DMH6XJG MT DTT DMH6XJG MA Modulator DMH6XJG RN DOI: 10.1038/ja.2013.86 DMH6XJG RU http://www.nature.com/ja/journal/v66/n10/fig_tab/ja201386t3.html DMVQARP DI DMVQARP DMVQARP DN WCK-771 DMVQARP MI TTN6J5F DMVQARP MN Bacterial DNA gyrase (Bact gyrase) DMVQARP MT DTT DMVQARP MA Modulator DMVQARP RN Antistaphylococcal Activity of WCK 771, a Tricyclic Fluoroquinolone, in Animal Infection Models DMVQARP RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC529196 DMVQARP DI DMVQARP DMVQARP DN WCK-771 DMVQARP MI TTIXTO3 DMVQARP MN Staphylococcus Topoisomerase IV (Stap-coc parC) DMVQARP MT DTT DMVQARP MA Modulator DMVQARP RN Antistaphylococcal Activity of WCK 771, a Tricyclic Fluoroquinolone, in Animal Infection Models DMVQARP RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC529196 DMZ67Q0 DI DMZ67Q0 DMZ67Q0 DN WT1 peptide vaccine DMZ67Q0 MI TTZ8UT4 DMZ67Q0 MN Wilms tumor protein (WT1) DMZ67Q0 MT DTT DMZ67Q0 RN Wilms' tumor protein 1 (WT1) peptide vaccination in AML patients: predominant TCR CDR3beta sequence associated with remission in one patient is detectable in other vaccinated patients. Cancer ImmunolImmunother. 2012 Mar;61(3):313-22. DMZ67Q0 RU https://pubmed.ncbi.nlm.nih.gov/21898091 DMNFZYE DI DMNFZYE DMNFZYE DN WT1-targeted autologous dendritic cell vaccine DMNFZYE MI TTZ8UT4 DMNFZYE MN Wilms tumor protein (WT1) DMNFZYE MT DTT DMNFZYE RN ClinicalTrials.gov (NCT01686334) Efficacy Study of Dendritic Cell Vaccination in Patients With Acute Myeloid Leukemia in Remission. U.S. National Institutes of Health. DMNFZYE RU https://clinicaltrials.gov/ct2/show/NCT01686334 DMFVNSB DI DMFVNSB DMFVNSB DN WY-50295-tromethamine DMFVNSB MI TT2J34L DMFVNSB MN Arachidonate 5-lipoxygenase (5-LOX) DMFVNSB MT DTT DMFVNSB MA Inhibitor DMFVNSB RN WY-50295 tromethamine: a 5-lipoxygenase inhibitor without activity in human whole blood. Prostaglandins Leukot Essent Fatty Acids. 1999 Jan;60(1):31-41. DMFVNSB RU https://pubmed.ncbi.nlm.nih.gov/10319915 DMW1NKO DI DMW1NKO DMW1NKO DN X-82 DMW1NKO MI TTI2WET DMW1NKO MN Platelet-derived growth factor receptor (PDGFR) DMW1NKO MT DTT DMW1NKO MA Modulator DMW1NKO RN National Cancer Institute Drug Dictionary (drug id 695817). DMW1NKO RU http://www.cancer.gov/publications/dictionaries/cancer-drug?cdrid=695817 DMW1NKO DI DMW1NKO DMW1NKO DN X-82 DMW1NKO MI TTVJ1D8 DMW1NKO MN Vascular endothelial growth factor receptor (VEGFR) DMW1NKO MT DTT DMW1NKO MA Inhibitor DMW1NKO RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMW1NKO RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DMW1NKO DI DMW1NKO DMW1NKO DN X-82 DMW1NKO MI TT2Q6G1 DMW1NKO MN Vascular endothelial growth factor receptor 1 (FLT-1) DMW1NKO MT DTT DMW1NKO MA Modulator DMW1NKO RN National Cancer Institute Drug Dictionary (drug id 695817). DMW1NKO RU http://www.cancer.gov/publications/dictionaries/cancer-drug?cdrid=695817 DMXG5WU DI DMXG5WU DMXG5WU DN Xanomeline tartrate DMXG5WU MI TTZ9SOR DMXG5WU MN Muscarinic acetylcholine receptor M1 (CHRM1) DMXG5WU MT DTT DMXG5WU MA Agonist DMXG5WU RN Pharmacological comparison of muscarinic ligands: historical versus more recent muscarinic M1-preferring receptor agonists. Eur J Pharmacol. 2009 Mar 1;605(1-3):53-6. DMXG5WU RU https://pubmed.ncbi.nlm.nih.gov/19168056 DM0NFMS DI DM0NFMS DM0NFMS DN XEN-2174 DM0NFMS MI TTAWNKZ DM0NFMS MN Norepinephrine transporter (NET) DM0NFMS MT DTT DM0NFMS MA Inhibitor DM0NFMS RN Spinal noradrenaline transporter inhibition by reboxetine and Xen2174 reduces tactile hypersensitivity after surgery in rats. Pain. 2005 Feb;113(3):271-6. DM0NFMS RU https://pubmed.ncbi.nlm.nih.gov/15661433 DMR69CG DI DMR69CG DMR69CG DN XEN-402 DMR69CG MI TT4G2JS DMR69CG MN Voltage-gated sodium channel alpha Nav1.7 (SCN9A) DMR69CG MT DTT DMR69CG MA Inhibitor DMR69CG RN Treatment of Na(v)1.7-mediated pain in inherited erythromelalgia using a novel sodium channel blocker. Pain. 2012 Jan;153(1):80-5. DMR69CG RU https://pubmed.ncbi.nlm.nih.gov/22035805 DMG7PDY DI DMG7PDY DMG7PDY DN XEN-D0501 DMG7PDY MI TTMI6F5 DMG7PDY MN Transient receptor potential cation channel V1 (TRPV1) DMG7PDY MT DTT DMG7PDY MA Antagonist DMG7PDY RN An investigation of the safety and pharmacokinetics of the novel TRPV1 antagonist XEN-D0501 in healthy subjects. Br J Clin Pharmacol. 2011 Dec;72(6):921-31. DMG7PDY RU https://pubmed.ncbi.nlm.nih.gov/21676011 DM4ZIDH DI DM4ZIDH DM4ZIDH DN Xentuzumab DM4ZIDH MI TTT6LOU DM4ZIDH MN Insulin-like growth factor-I (IGF1) DM4ZIDH MT DTT DM4ZIDH RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DM4ZIDH RU http://phrma-docs.phrma.org/files/dmfile/MID_Immuno-Oncology-2017_Drug-List1.pdf DM4ZIDH DI DM4ZIDH DM4ZIDH DN Xentuzumab DM4ZIDH MI TTE8WGO DM4ZIDH MN Insulin-like growth factor-II (IGF2) DM4ZIDH MT DTT DM4ZIDH RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DM4ZIDH RU http://phrma-docs.phrma.org/files/dmfile/MID_Immuno-Oncology-2017_Drug-List1.pdf DMML7BE DI DMML7BE DMML7BE DN Xl147 DMML7BE MI DEAWHS8 DMML7BE MN Aldehyde oxidase (AOX1) DMML7BE MT DME DMML7BE MA Metabolism DMML7BE RN Characterization of aldehyde oxidase enzyme activity in cryopreserved human hepatocytes. Drug Metab Dispos. 2012 Feb;40(2):267-75. DMML7BE RU https://www.ncbi.nlm.nih.gov/pubmed/?term=22031625 DMML7BE DI DMML7BE DMML7BE DN Xl147 DMML7BE MI TTHBTOP DMML7BE MN PI3-kinase gamma (PIK3CG) DMML7BE MT DTT DMML7BE MA Modulator DMML7BE RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2156). DMML7BE RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2156 DMMHX9K DI DMMHX9K DMMHX9K DN XL-820 DMMHX9K MI TT8FYO9 DMMHX9K MN Platelet-derived growth factor receptor alpha (PDGFRA) DMMHX9K MT DTT DMMHX9K MA Inhibitor DMMHX9K RN National Cancer Institute Drug Dictionary (drug id 452042). DMMHX9K RU http://www.cancer.gov/publications/dictionaries/cancer-drug?cdrid=452042 DMMHX9K DI DMMHX9K DMMHX9K DN XL-820 DMMHX9K MI TTI7421 DMMHX9K MN Platelet-derived growth factor receptor beta (PDGFRB) DMMHX9K MT DTT DMMHX9K MA Inhibitor DMMHX9K RN National Cancer Institute Drug Dictionary (drug id 452042). DMMHX9K RU http://www.cancer.gov/publications/dictionaries/cancer-drug?cdrid=452042 DMMHX9K DI DMMHX9K DMMHX9K DN XL-820 DMMHX9K MI TTX41N9 DMMHX9K MN Tyrosine-protein kinase Kit (KIT) DMMHX9K MT DTT DMMHX9K MA Inhibitor DMMHX9K RN National Cancer Institute Drug Dictionary (drug id 452042). DMMHX9K RU http://www.cancer.gov/publications/dictionaries/cancer-drug?cdrid=452042 DMMHX9K DI DMMHX9K DMMHX9K DN XL-820 DMMHX9K MI TTVJ1D8 DMMHX9K MN Vascular endothelial growth factor receptor (VEGFR) DMMHX9K MT DTT DMMHX9K MA Inhibitor DMMHX9K RN National Cancer Institute Drug Dictionary (drug id 452042). DMMHX9K RU http://www.cancer.gov/publications/dictionaries/cancer-drug?cdrid=452042 DMHJTR2 DI DMHJTR2 DMHJTR2 DN XL880 DMHJTR2 MI TTNDSF4 DMHJTR2 MN Proto-oncogene c-Met (MET) DMHJTR2 MT DTT DMHJTR2 MA Modulator DMHJTR2 RN Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41. DMHJTR2 RU https://www.ncbi.nlm.nih.gov/pubmed/15950434 DMHJTR2 DI DMHJTR2 DMHJTR2 DN XL880 DMHJTR2 MI TTUTJGQ DMHJTR2 MN Vascular endothelial growth factor receptor 2 (KDR) DMHJTR2 MT DTT DMHJTR2 MA Modulator DMHJTR2 RN Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41. DMHJTR2 RU https://www.ncbi.nlm.nih.gov/pubmed/15950434 DMVB8EO DI DMVB8EO DMVB8EO DN XLCART001 DMVB8EO MI TTW640A DMVB8EO MN B-lymphocyte surface antigen B4 (CD19) DMVB8EO MT DTT DMVB8EO MA CAR-T-Cell-Therapy DMVB8EO RN ClinicalTrials.gov (NCT03598179) XLCART001 Treatment in Relapsed/Refractory/High-risk B-cell Malignancy Subjects DMVB8EO RU https://clinicaltrials.gov/ct2/show/NCT03598179 DMLIPY1 DI DMLIPY1 DMLIPY1 DN Xmab 5871 DMLIPY1 MI TTW640A DMLIPY1 MN B-lymphocyte surface antigen B4 (CD19) DMLIPY1 MT DTT DMLIPY1 MA Modulator DMLIPY1 RN Suppression of rheumatoid arthritis B cells by XmAb5871, an anti-CD19 antibody that coengages B cell antigen receptor complex and Fc receptor IIb inhibitory receptor.Arthritis Rheumatol.2014 May;66(5):1153-64. DMLIPY1 RU https://www.ncbi.nlm.nih.gov/pubmed/24782179 DMLIPY1 DI DMLIPY1 DMLIPY1 DN Xmab 5871 DMLIPY1 MI TT5RWKQ DMLIPY1 MN Immunoglobulin gamma Fc receptor IIB (FCGR2B) DMLIPY1 MT DTT DMLIPY1 MA Modulator DMLIPY1 RN CD19 as an attractive target for antibody-based therapy. MAbs. 2012 Sep-Oct;4(5):571-7. DMLIPY1 RU https://pubmed.ncbi.nlm.nih.gov/22820352 DMWEB07 DI DMWEB07 DMWEB07 DN XOMA-629 DMWEB07 MI TTXCSDR DMWEB07 MN Protein bactericidal permeability-increasing (BPI) DMWEB07 MT DTT DMWEB07 MA Inhibitor DMWEB07 RN Modulating immunity as a therapy for bacterial infections. Nat Rev Microbiol. 2012 Mar 16;10(4):243-54. DMWEB07 RU https://pubmed.ncbi.nlm.nih.gov/22421877 DM8N3ZQ DI DM8N3ZQ DM8N3ZQ DN XP-21279 DM8N3ZQ MI TTEX248 DM8N3ZQ MN Dopamine D2 receptor (D2R) DM8N3ZQ MT DTT DM8N3ZQ MA Agonist DM8N3ZQ RN Double-blind study of the actively transported levodopa prodrug XP21279 in Parkinson's disease. Mov Disord. 2014 Jan;29(1):75-82. DM8N3ZQ RU https://pubmed.ncbi.nlm.nih.gov/24339234 DMELUYN DI DMELUYN DMELUYN DN XP-23829 DMELUYN MI TTSXVID DMELUYN MN Nuclear factor NF-kappa-B (NFKB) DMELUYN MT DTT DMELUYN MA Inhibitor DMELUYN RN Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800036491) DMELUYN RU http://adisinsight.springer.com/drugs/800036491 DMOKUA5 DI DMOKUA5 DMOKUA5 DN XR-5000 DMOKUA5 MI TTGTQHC DMOKUA5 MN DNA topoisomerase I (TOP1) DMOKUA5 MT DTT DMOKUA5 MA Modulator DMOKUA5 RN Phase II study of XR5000 (DACA) administered as a 120-h infusion in patients with recurrent glioblastoma multiforme. Ann Oncol. 2002 May;13(5):777-80. DMOKUA5 RU https://pubmed.ncbi.nlm.nih.gov/12075748 DMOKUA5 DI DMOKUA5 DMOKUA5 DN XR-5000 DMOKUA5 MI TT0IHXV DMOKUA5 MN DNA topoisomerase II (TOP2) DMOKUA5 MT DTT DMOKUA5 MA Modulator DMOKUA5 RN Phase II study of XR5000 (DACA) administered as a 120-h infusion in patients with recurrent glioblastoma multiforme. Ann Oncol. 2002 May;13(5):777-80. DMOKUA5 RU https://pubmed.ncbi.nlm.nih.gov/12075748 DMPI6N0 DI DMPI6N0 DMPI6N0 DN XZK-monascus DMPI6N0 MI TTPADOQ DMPI6N0 MN HMG-CoA reductase (HMGCR) DMPI6N0 MT DTT DMPI6N0 MA Modulator DMPI6N0 RN NMR evaluation of total statin content and HMG-CoA reductase inhibition in red yeast rice (Monascus spp.) food supplements. Chin Med. 2012 Mar 22;7:8. DMPI6N0 RU https://pubmed.ncbi.nlm.nih.gov/22439629 DM54MAJ DI DM54MAJ DM54MAJ DN YF-476 DM54MAJ MI TTVFO0U DM54MAJ MN Gastrin/cholecystokinin type B receptor (CCKBR) DM54MAJ MT DTT DM54MAJ MA Inhibitor DM54MAJ RN CCK-B receptor antagonist YF476 inhibits pancreatic enzyme secretion at a duodenal level in pigs. Scand J Gastroenterol. 2004 Sep;39(9):886-90. DM54MAJ RU https://pubmed.ncbi.nlm.nih.gov/15513388 DMCHFB0 DI DMCHFB0 DMCHFB0 DN YH-4808 DMCHFB0 MI TTLOKXP DMCHFB0 MN Gastric H(+)/K(+) ATPase (Proton pump) DMCHFB0 MT DTT DMCHFB0 MA Modulator DMCHFB0 RN Poor effectiveness of proton pump inhibitors in non-erosive reflux disease: the truth in the end! Neurogastroenterol Motil.2012 Aug;24(8):697-704. DMCHFB0 RU https://www.ncbi.nlm.nih.gov/pubmed/22783985 DM740LV DI DM740LV DM740LV DN YKP-GI DM740LV MI TT07C3Y DM740LV MN 5-HT 4 receptor (HTR4) DM740LV MT DTT DM740LV MA Agonist DM740LV RN A randomized trial of 5-hydroxytryptamine4-receptor agonist, YKP10811, on colonic transit and bowel function in functional constipation. Clin Gastroenterol Hepatol. 2015 Apr;13(4):701-8.e1. DM740LV RU https://pubmed.ncbi.nlm.nih.gov/25148765 DM5Q1W4 DI DM5Q1W4 DM5Q1W4 DN Ym155 DM5Q1W4 MI DTT79CX DM5Q1W4 MN Organic cation transporter 1 (SLC22A1) DM5Q1W4 MT DTP DM5Q1W4 MA Substrate DM5Q1W4 RN Characterization of human organic cation transporter 1 (OCT1/SLC22A1)- and OCT2 (SLC22A2)-mediated transport of 1-(2-methoxyethyl)-2-methyl-4,9-dioxo-3-(pyrazin-2-ylmethyl)- 4,9-dihydro-1H-naphtho[2,3-d]imidazolium bromide (YM155 monobromide), a novel small molecule survivin suppressant. Drug Metab Dispos. 2010 Jan;38(1):1-4. DM5Q1W4 RU http://www.ncbi.nlm.nih.gov/pubmed/19833842 DM5Q1W4 DI DM5Q1W4 DM5Q1W4 DN Ym155 DM5Q1W4 MI DT9IDPW DM5Q1W4 MN Organic cation transporter 2 (SLC22A2) DM5Q1W4 MT DTP DM5Q1W4 MA Substrate DM5Q1W4 RN Characterization of human organic cation transporter 1 (OCT1/SLC22A1)- and OCT2 (SLC22A2)-mediated transport of 1-(2-methoxyethyl)-2-methyl-4,9-dioxo-3-(pyrazin-2-ylmethyl)- 4,9-dihydro-1H-naphtho[2,3-d]imidazolium bromide (YM155 monobromide), a novel small molecule survivin suppressant. Drug Metab Dispos. 2010 Jan;38(1):1-4. DM5Q1W4 RU http://www.ncbi.nlm.nih.gov/pubmed/19833842 DMAZNVX DI DMAZNVX DMAZNVX DN YM-264 DMAZNVX MI TTQL5VC DMAZNVX MN Platelet-activating factor receptor (PTAFR) DMAZNVX MT DTT DMAZNVX MA Antagonist DMAZNVX RN Effects of YM264, a novel PAF antagonist, on puromycin aminonucleoside-induced nephropathy in the rat. Biochem Biophys Res Commun. 1991 Apr 30;176(2):781-5. DMAZNVX RU https://pubmed.ncbi.nlm.nih.gov/2025290 DMS7609 DI DMS7609 DMS7609 DN YM-358 DMS7609 MI TT8DBY3 DMS7609 MN Angiotensin II receptor type-1 (AGTR1) DMS7609 MT DTT DMS7609 MA Antagonist DMS7609 RN Effects of YM358, an angiotensin II type 1 (AT1) receptor antagonist, and enalapril on blood pressure and vasoconstriction in two renal hypertension models. Biol Pharm Bull. 2000 Feb;23(2):174-81. DMS7609 RU https://pubmed.ncbi.nlm.nih.gov/10706380 DMKJF6H DI DMKJF6H DMKJF6H DN YM-430 DMKJF6H MI TTMXGCW DMKJF6H MN Adrenergic receptor beta-3 (ADRB3) DMKJF6H MT DTT DMKJF6H MA Modulator DMKJF6H RN Cardiovascular effects of YM430, a 1,4-dihydropyridine derivative with beta-adrenoceptor blocking activity, in dogs and rats. Biol Pharm Bull. 1997 Mar;20(3):230-6. DMKJF6H RU https://pubmed.ncbi.nlm.nih.gov/9084878 DMRZBPI DI DMRZBPI DMRZBPI DN YM-543 DMRZBPI MI TTLWPVF DMRZBPI MN Sodium/glucose cotransporter 2 (SGLT2) DMRZBPI MT DTT DMRZBPI MA Modulator DMRZBPI RN Pharmacological Characterization of YM543, a Newly Synthesized, Orally Active SGLT2 Selective Inhibitor. Endocr Res. 2013 Aug;38(3):168-183. DMRZBPI RU https://www.ncbi.nlm.nih.gov/pubmed/23374077 DMUPJWH DI DMUPJWH DMUPJWH DN YM-598 DMUPJWH MI TTKRD0G DMUPJWH MN Endothelin A receptor (EDNRA) DMUPJWH MT DTT DMUPJWH MA Antagonist DMUPJWH RN Role of the endothelin axis and its antagonists in the treatment of cancer. Br J Pharmacol. 2011 May; 163(2): 220-233. DMUPJWH RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3087127/ DMU79X2 DI DMU79X2 DMU79X2 DN Ym-758 DMU79X2 MI DT3D8F0 DMU79X2 MN Organic anion transporting polypeptide 1B1 (SLCO1B1) DMU79X2 MT DTP DMU79X2 MA Substrate DMU79X2 RN Organic anion transporting polypeptide 1B1: a genetically polymorphic transporter of major importance for hepatic drug uptake. Pharmacol Rev. 2011 Mar;63(1):157-81. DMU79X2 RU http://www.ncbi.nlm.nih.gov/pubmed/21245207 DM7KR4C DI DM7KR4C DM7KR4C DN YM-934 DM7KR4C MI TT1VOHK DM7KR4C MN Potassium channel unspecific (KC) DM7KR4C MT DTT DM7KR4C MA Blocker DM7KR4C RN Potassium channel opener, YM 934, inhibits neurogenic plasma leakage in guinea pig airways. Am J Respir Crit Care Med. 1994 Nov;150(5 Pt 1):1379-83. DM7KR4C RU https://pubmed.ncbi.nlm.nih.gov/7524979 DM0K8U7 DI DM0K8U7 DM0K8U7 DN YSIL6 DM0K8U7 MI TTT1V78 DM0K8U7 MN Interleukin-6 (IL6) DM0K8U7 MT DTT DM0K8U7 MA Inhibitor DM0K8U7 RN Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800020380) DM0K8U7 RU http://adisinsight.springer.com/drugs/800020380 DM3YVKQ DI DM3YVKQ DM3YVKQ DN YT-146 DM3YVKQ MI TTNE7KG DM3YVKQ MN Adenosine A2b receptor (ADORA2B) DM3YVKQ MT DTT DM3YVKQ MA Agonist DM3YVKQ RN Identification of adenosine A2 receptor-cAMP system in human aortic endothelial cells. Biochem Biophys Res Commun. 1994 Mar 15;199(2):905-10. DM3YVKQ RU https://pubmed.ncbi.nlm.nih.gov/8135838 DM2M80G DI DM2M80G DM2M80G DN Z 360 DM2M80G MI TTVFO0U DM2M80G MN Gastrin/cholecystokinin type B receptor (CCKBR) DM2M80G MT DTT DM2M80G MA Modulator DM2M80G RN Z-360, a novel cholecystokinin-2/gastrin receptor antagonist, inhibits gemcitabine-induced expression of the vascular endothelial growth factor gen... Biol Pharm Bull. 2010;33(2):216-22. DM2M80G RU https://www.ncbi.nlm.nih.gov/pubmed/20118543 DMUT9OE DI DMUT9OE DMUT9OE DN Zadaxin/lamivudine DMUT9OE MI TTSYFMA DMUT9OE MN Interferon alpha/beta receptor 1 (IFNAR1) DMUT9OE MT DTT DMUT9OE MA Modulator DMUT9OE RN Zadaxin (thymosin alpha1) for the treatment of viral hepatitis. Expert Opin Investig Drugs. 1999 Mar;8(3):281-7. DMUT9OE RU https://pubmed.ncbi.nlm.nih.gov/15992078 DMUT9OE DI DMUT9OE DMUT9OE DN Zadaxin/lamivudine DMUT9OE MI TTSHG0T DMUT9OE MN Toll-like receptor 9 (TLR9) DMUT9OE MT DTT DMUT9OE MA Modulator DMUT9OE RN Zadaxin (thymosin alpha1) for the treatment of viral hepatitis. Expert Opin Investig Drugs. 1999 Mar;8(3):281-7. DMUT9OE RU https://pubmed.ncbi.nlm.nih.gov/15992078 DMJN3BA DI DMJN3BA DMJN3BA DN Zalospirone DMJN3BA MI TTSQIFT DMJN3BA MN 5-HT 1A receptor (HTR1A) DMJN3BA MT DTT DMJN3BA MA Agonist DMJN3BA RN The serotonin 5-HT receptor agonist tandospirone improves executive function in common marmosets. Behav Brain Res. 2015 Jul 1;287:120-6. DMJN3BA RU https://pubmed.ncbi.nlm.nih.gov/25804359 DMTYD8Q DI DMTYD8Q DMTYD8Q DN ZD2079 DMTYD8Q MI TTMXGCW DMTYD8Q MN Adrenergic receptor beta-3 (ADRB3) DMTYD8Q MT DTT DMTYD8Q MA Agonist DMTYD8Q RN Urinary tract toxicity in rats following administration of beta 3-adrenoceptor agonists. Toxicol Pathol. 1999 Mar-Apr;27(2):165-70. DMTYD8Q RU https://pubmed.ncbi.nlm.nih.gov/10207980 DMH85M0 DI DMH85M0 DMH85M0 DN ZD-6126 DMH85M0 MI TTYFKSZ DMH85M0 MN Tubulin beta (TUBB) DMH85M0 MT DTT DMH85M0 MA Inhibitor DMH85M0 RN Phase I clinical evaluation of ZD6126, a novel vascular-targeting agent, in patients with solid tumors. Invest New Drugs. 2008 Apr;26(2):159-67. DMH85M0 RU https://pubmed.ncbi.nlm.nih.gov/18219445 DMPE2B9 DI DMPE2B9 DMPE2B9 DN ZD-7288 DMPE2B9 MI TTKLW9S DMPE2B9 MN Hyperpolarization cyclic nucleotide-gated channel (HCN) DMPE2B9 MT DTT DMPE2B9 MA Modulator DMPE2B9 RN ZD 7288, an HCN channel blocker, attenuates chronic visceral pain in irritable bowel syndrome-like rats. World J Gastroenterol. 2014 Feb 28;20(8):2091-7. DMPE2B9 RU https://pubmed.ncbi.nlm.nih.gov/24587682 DM6VQTF DI DM6VQTF DM6VQTF DN ZEN-3694 DM6VQTF MI TTE4BSY DM6VQTF MN Bromodomain and extraterminal domain protein (BET) DM6VQTF MT DTT DM6VQTF MA Inhibitor DM6VQTF RN Clinical pipeline report, company report or official report of Zenith Epigenetics. DM6VQTF RU https://www.zenithepigenetics.com/programs/pipeline DM9KB7A DI DM9KB7A DM9KB7A DN ZGN-1061 DM9KB7A MI TTZL0OI DM9KB7A MN Methionine aminopeptidase 2 (METAP2) DM9KB7A MT DTT DM9KB7A MA Inhibitor DM9KB7A RN The methionine aminopeptidase 2 inhibitor ZGN-1061 improves glucose control and weight in overweight and obese individuals with type 2 diabetes: A randomized, placebo-controlled trial. Diabetes Obes Metab. 2020 Jul;22(7):1215-1219. DM9KB7A RU https://pubmed.ncbi.nlm.nih.gov/32077231 DMJ94L0 DI DMJ94L0 DMJ94L0 DN ZK-91587 DMJ94L0 MI TT26PHO DMJ94L0 MN Mineralocorticoid receptor (MR) DMJ94L0 MT DTT DMJ94L0 MA Antagonist DMJ94L0 RN ZK91587: a novel synthetic antimineralocorticoid displays high affinity for corticosterone (type I) receptors in the rat hippocampus. Life Sci. 1988;43(19):1537-43. DMJ94L0 RU https://pubmed.ncbi.nlm.nih.gov/3193846 DM4MSLY DI DM4MSLY DM4MSLY DN ZN-c3 DM4MSLY MI TTJFOAL DM4MSLY MN Wee1-like protein kinase (WEE1) DM4MSLY MT DTT DM4MSLY MA Inhibitor DM4MSLY RN Clinical pipeline report, company report or official report of Zentalis Pharmaceuticals. DM4MSLY RU https://zentalis.com/our-pipeline/pipeline/ DMG7YI9 DI DMG7YI9 DMG7YI9 DN ZYH7 DMG7YI9 MI TTJ584C DMG7YI9 MN Peroxisome proliferator-activated receptor alpha (PPARA) DMG7YI9 MT DTT DMG7YI9 MA Agonist DMG7YI9 RN Clinical pipeline report, company report or official report of Zydus Cadila. DMG7YI9 RU https://zyduscadila.com/public/pdf/investorpresentation/Investor_Presentation_February_2020.pdf DMTXBUV DI DMTXBUV DMTXBUV DN BT1718 DMTXBUV MI TTJ4QE7 DMTXBUV MN Matrix metalloproteinase-14 (MMP-14) DMTXBUV MT DTT DMTXBUV MA Inhibitor DMTXBUV RN ClinicalTrials.gov (NCT03486730) BT1718 in Patients With Advanced Solid Tumours.. U.S. National Institutes of Health. DMTXBUV RU https://clinicaltrials.gov/ct2/show/NCT03486730 DM824EG DI DM824EG DM824EG DN COVA322 DM824EG MI TTG0MT6 DM824EG MN Interleukin-17 (IL17) DM824EG MT DTT DM824EG MA Modulator DM824EG RN Bispecific antibodies rise again. Nat Rev Drug Discov. 2014 Nov;13(11):799-801. DM824EG RU https://www.ncbi.nlm.nih.gov/pubmed/25359367 DM824EG DI DM824EG DM824EG DN COVA322 DM824EG MI TTF8CQI DM824EG MN Tumor necrosis factor (TNF) DM824EG MT DTT DM824EG MA Modulator DM824EG RN Bispecific antibodies rise again. Nat Rev Drug Discov. 2014 Nov;13(11):799-801. DM824EG RU https://www.ncbi.nlm.nih.gov/pubmed/25359367 DMJ1NG4 DI DMJ1NG4 DMJ1NG4 DN Dalazatide DMJ1NG4 MI TTY3UE6 DMJ1NG4 MN Voltage-gated potassium channel Kv1.3 (KCNA3) DMJ1NG4 MT DTT DMJ1NG4 MA Inhibitor DMJ1NG4 RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMJ1NG4 RU http://phrma-docs.phrma.org/files/dmfile/medicines-in-development-drug-list-autoimmune-diseases.pdf DMV401D DI DMV401D DMV401D DN Debio-0824 DMV401D MI TTY3UE6 DMV401D MN Voltage-gated potassium channel Kv1.3 (KCNA3) DMV401D MT DTT DMV401D MA Inhibitor DMV401D RN Durable Pharmacological Responses from the Peptide ShK-186, a Specific Kv1.3 Channel Inhibitor That Suppresses T Cell Mediators of Autoimmune Disease. J Pharmacol Exp Ther. 2012 September; 342(3): 642-653. DMV401D RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3422530/ DMT17XU DI DMT17XU DMT17XU DN 131I-radretumab DMT17XU MI TTBVIQC DMT17XU MN Integrin beta-1 (ITGB1) DMT17XU MT DTT DMT17XU RN Radretumab radioimmunotherapy in patients with brain metastasis: a 124I-L19SIP dosimetric PET study. Cancer Immunol Res. 2013 Aug;1(2):134-43. DMT17XU RU https://pubmed.ncbi.nlm.nih.gov/24777501 DMVZ9XL DI DMVZ9XL DMVZ9XL DN 177Lu-labelled DOTA-JR11 DMVZ9XL MI TTOMNR9 DMVZ9XL MN Somatostatin receptor (SSTR) DMVZ9XL MT DTT DMVZ9XL RN Multimodal Imaging of 2-Cycle PRRT with 177 Lu-DOTA-JR11 and 177 Lu-DOTATOC in an Orthotopic Neuroendocrine Xenograft Tumor Mouse Model. J Nucl Med. 2021 Mar;62(3):393-398. DMVZ9XL RU https://pubmed.ncbi.nlm.nih.gov/32859703 DMWPD7N DI DMWPD7N DMWPD7N DN 177Lu-labelled PSMA-R2 DMWPD7N MI TT9G4N0 DMWPD7N MN Glutamate carboxypeptidase II (GCPII) DMWPD7N MT DTT DMWPD7N RN Radiopharmaceutical therapy in cancer: clinical advances and challenges. Nat Rev Drug Discov. 2020 Sep;19(9):589-608. DMWPD7N RU https://pubmed.ncbi.nlm.nih.gov/32728208 DM6JLNT DI DM6JLNT DM6JLNT DN 177-Lu-NeoB DM6JLNT MI TTC1MVT DM6JLNT MN Gastrin-releasing peptide receptor (GRPR) DM6JLNT MT DTT DM6JLNT MA Antagonist DM6JLNT RN 68Ga/177Lu-NeoBOMB1, a Novel Radiolabeled GRPR Antagonist for Theranostic Use in Oncology. J Nucl Med. 2017 Feb;58(2):293-299. DM6JLNT RU https://pubmed.ncbi.nlm.nih.gov/27609789 DMF4AOE DI DMF4AOE DMF4AOE DN 177-Lu-PSMA-R2 DMF4AOE MI TT9G4N0 DMF4AOE MN Glutamate carboxypeptidase II (GCPII) DMF4AOE MT DTT DMF4AOE MA Agonist DMF4AOE RN National Cancer Institute Drug Dictionary (drug name Lu-177-PSMA-R2). DMF4AOE RU https://www.cancer.gov/publications/dictionaries/cancer-drug/def/lutetium-lu-177-psma-r2 DMCLKA4 DI DMCLKA4 DMCLKA4 DN 2-hydroxyoleic acid DMCLKA4 MI TTBOE28 DMCLKA4 MN Sphingomyelin synthase (SMS) DMCLKA4 MT DTT DMCLKA4 MA Modulator DMCLKA4 RN Sphingomyelin and sphingomyelin synthase (SMS) in the malignant transformation of glioma cells and in 2-hydroxyoleic acid therapy. Proc Natl Acad Sci U S A. 2011 Dec 6;108(49):19569-74. DMCLKA4 RU https://pubmed.ncbi.nlm.nih.gov/22106271 DMYPQT4 DI DMYPQT4 DMYPQT4 DN 4SCAR19 and 4SCAR123 DMYPQT4 MI TTW640A DMYPQT4 MN B-lymphocyte surface antigen B4 (CD19) DMYPQT4 MT DTT DMYPQT4 MA CAR-T-Cell-Therapy(Dual specific) DMYPQT4 RN ClinicalTrials.gov (NCT03125577) Combination CAR-T Cell Therapy Targeting Hematological Malignancies DMYPQT4 RU https://clinicaltrials.gov/ct2/show/NCT03125577 DMYPQT4 DI DMYPQT4 DMYPQT4 DN 4SCAR19 and 4SCAR123 DMYPQT4 MI TTENHJ0 DMYPQT4 MN Interleukin 3 receptor alpha (IL3RA) DMYPQT4 MT DTT DMYPQT4 MA CAR-T-Cell-Therapy(Dual specific) DMYPQT4 RN ClinicalTrials.gov (NCT03125577) Combination CAR-T Cell Therapy Targeting Hematological Malignancies DMYPQT4 RU https://clinicaltrials.gov/ct2/show/NCT03125577 DMFVTSG DI DMFVTSG DMFVTSG DN 4SCAR19 and 4SCAR20 DMFVTSG MI TTW640A DMFVTSG MN B-lymphocyte surface antigen B4 (CD19) DMFVTSG MT DTT DMFVTSG MA CAR-T-Cell-Therapy(Dual specific) DMFVTSG RN ClinicalTrials.gov (NCT03125577) Combination CAR-T Cell Therapy Targeting Hematological Malignancies DMFVTSG RU https://clinicaltrials.gov/ct2/show/NCT03125577 DMFVTSG DI DMFVTSG DMFVTSG DN 4SCAR19 and 4SCAR20 DMFVTSG MI TTUE541 DMFVTSG MN Leukocyte surface antigen Leu-16 (CD20) DMFVTSG MT DTT DMFVTSG MA CAR-T-Cell-Therapy(Dual specific) DMFVTSG RN ClinicalTrials.gov (NCT03125577) Combination CAR-T Cell Therapy Targeting Hematological Malignancies DMFVTSG RU https://clinicaltrials.gov/ct2/show/NCT03125577 DM8CMUW DI DM8CMUW DM8CMUW DN 4SCAR19 and 4SCAR22 DM8CMUW MI TTM6QSK DM8CMUW MN B-cell receptor CD22 (CD22) DM8CMUW MT DTT DM8CMUW MA CAR-T-Cell-Therapy(Dual specific) DM8CMUW RN ClinicalTrials.gov (NCT03125577) Combination CAR-T Cell Therapy Targeting Hematological Malignancies DM8CMUW RU https://clinicaltrials.gov/ct2/show/NCT03125577 DM8CMUW DI DM8CMUW DM8CMUW DN 4SCAR19 and 4SCAR22 DM8CMUW MI TTW640A DM8CMUW MN B-lymphocyte surface antigen B4 (CD19) DM8CMUW MT DTT DM8CMUW MA CAR-T-Cell-Therapy(Dual specific) DM8CMUW RN ClinicalTrials.gov (NCT03125577) Combination CAR-T Cell Therapy Targeting Hematological Malignancies DM8CMUW RU https://clinicaltrials.gov/ct2/show/NCT03125577 DMUYFS1 DI DMUYFS1 DMUYFS1 DN 4SCAR19 and 4SCAR30 DMUYFS1 MI TTW640A DMUYFS1 MN B-lymphocyte surface antigen B4 (CD19) DMUYFS1 MT DTT DMUYFS1 MA CAR-T-Cell-Therapy(Dual specific) DMUYFS1 RN ClinicalTrials.gov (NCT03125577) Combination CAR-T Cell Therapy Targeting Hematological Malignancies DMUYFS1 RU https://clinicaltrials.gov/ct2/show/NCT03125577 DMUYFS1 DI DMUYFS1 DMUYFS1 DN 4SCAR19 and 4SCAR30 DMUYFS1 MI TT2GM5R DMUYFS1 MN Lymphocyte activation antigen CD30 (TNFRSF8) DMUYFS1 MT DTT DMUYFS1 MA CAR-T-Cell-Therapy(Dual specific) DMUYFS1 RN ClinicalTrials.gov (NCT03125577) Combination CAR-T Cell Therapy Targeting Hematological Malignancies DMUYFS1 RU https://clinicaltrials.gov/ct2/show/NCT03125577 DMZKFU7 DI DMZKFU7 DMZKFU7 DN 4SCAR19 and 4SCAR38 DMZKFU7 MI TTW640A DMZKFU7 MN B-lymphocyte surface antigen B4 (CD19) DMZKFU7 MT DTT DMZKFU7 MA CAR-T-Cell-Therapy(Dual specific) DMZKFU7 RN ClinicalTrials.gov (NCT03125577) Combination CAR-T Cell Therapy Targeting Hematological Malignancies DMZKFU7 RU https://clinicaltrials.gov/ct2/show/NCT03125577 DMZKFU7 DI DMZKFU7 DMZKFU7 DN 4SCAR19 and 4SCAR38 DMZKFU7 MI TTPURFN DMZKFU7 MN Cyclic ADP-ribose hydrolase 1 (CD38) DMZKFU7 MT DTT DMZKFU7 MA CAR-T-Cell-Therapy(Dual specific) DMZKFU7 RN ClinicalTrials.gov (NCT03125577) Combination CAR-T Cell Therapy Targeting Hematological Malignancies DMZKFU7 RU https://clinicaltrials.gov/ct2/show/NCT03125577 DMKC8F9 DI DMKC8F9 DMKC8F9 DN 4SCAR19 and 4SCAR70 DMKC8F9 MI TTW640A DMKC8F9 MN B-lymphocyte surface antigen B4 (CD19) DMKC8F9 MT DTT DMKC8F9 MA CAR-T-Cell-Therapy(Dual specific) DMKC8F9 RN ClinicalTrials.gov (NCT03125577) Combination CAR-T Cell Therapy Targeting Hematological Malignancies DMKC8F9 RU https://clinicaltrials.gov/ct2/show/NCT03125577 DMKC8F9 DI DMKC8F9 DMKC8F9 DN 4SCAR19 and 4SCAR70 DMKC8F9 MI TTNCIE0 DMKC8F9 MN CD70 antigen (CD27-L) DMKC8F9 MT DTT DMKC8F9 MA CAR-T-Cell-Therapy(Dual specific) DMKC8F9 RN ClinicalTrials.gov (NCT03125577) Combination CAR-T Cell Therapy Targeting Hematological Malignancies DMKC8F9 RU https://clinicaltrials.gov/ct2/show/NCT03125577 DMIY1ZB DI DMIY1ZB DMIY1ZB DN 4SCAR19 cells DMIY1ZB MI TTW640A DMIY1ZB MN B-lymphocyte surface antigen B4 (CD19) DMIY1ZB MT DTT DMIY1ZB MA CAR-T-Cell-Therapy DMIY1ZB RN ClinicalTrials.gov (NCT03050190) A Phase I/II Multiple Center Trial of 4SCAR19 Cells in the Treatment of Relapsed and Refractory B Cell Malignancies DMIY1ZB RU https://clinicaltrials.gov/ct2/show/NCT03050190 DMI8TW3 DI DMI8TW3 DMI8TW3 DN 4SCAR19/22 T cells DMI8TW3 MI TTM6QSK DMI8TW3 MN B-cell receptor CD22 (CD22) DMI8TW3 MT DTT DMI8TW3 MA CAR-T-Cell-Therapy(Dual specific) DMI8TW3 RN ClinicalTrials.gov (NCT03098355) Interleukin-2 Following 4SCAR19/22 T Cells Targeting Refractory and/or Recurrent B Cell Malignancies DMI8TW3 RU https://clinicaltrials.gov/ct2/show/NCT03098355 DMI8TW3 DI DMI8TW3 DMI8TW3 DN 4SCAR19/22 T cells DMI8TW3 MI TTW640A DMI8TW3 MN B-lymphocyte surface antigen B4 (CD19) DMI8TW3 MT DTT DMI8TW3 MA CAR-T-Cell-Therapy(Dual specific) DMI8TW3 RN ClinicalTrials.gov (NCT03098355) Interleukin-2 Following 4SCAR19/22 T Cells Targeting Refractory and/or Recurrent B Cell Malignancies DMI8TW3 RU https://clinicaltrials.gov/ct2/show/NCT03098355 DMEGSU5 DI DMEGSU5 DMEGSU5 DN 4SCAR-GD2 DMEGSU5 MI TT80ARU DMEGSU5 MN Ganglioside GD2 (GD2) DMEGSU5 MT DTT DMEGSU5 MA CAR-T-Cell-Therapy DMEGSU5 RN ClinicalTrials.gov (NCT02992210) Study on GD2 Positive Solid Tumors by 4SCAR-GD2 DMEGSU5 RU https://clinicaltrials.gov/ct2/show/NCT02992210 DMM8J5W DI DMM8J5W DMM8J5W DN 4SCAR-PSMA DMM8J5W MI TT9G4N0 DMM8J5W MN Glutamate carboxypeptidase II (GCPII) DMM8J5W MT DTT DMM8J5W MA CAR-T-Cell-Therapy DMM8J5W RN ClinicalTrials.gov (NCT03185468) Intervention of Bladder Cancer by CAR-T DMM8J5W RU https://clinicaltrials.gov/ct2/show/NCT03185468 DM129VT DI DM129VT DM129VT DN 514G3 DM129VT MI TTOWKQ9 DM129VT MN Staphylococcus IgG binding protein A (Stap-coc SpA) DM129VT MT DTT DM129VT MA Inhibitor DM129VT RN A natural human monoclonal antibody targeting Staphylococcus Protein A protects against Staphylococcus aureus bacteremia. PLoS One. 2018 Jan 24;13(1):e0190537. DM129VT RU https://pubmed.ncbi.nlm.nih.gov/29364906 DMFAMNH DI DMFAMNH DMFAMNH DN 99mTc-rBitistatin DMFAMNH MI TT38RM1 DMFAMNH MN Glycoprotein IIb/IIIa receptor (GPIIb/IIIa) DMFAMNH MT DTT DMFAMNH MA Modulator DMFAMNH RN Platelet binding and biodistribution of [99mTc]rBitistatin in animal species and humans. Nucl Med Biol. 2007 Oct;34(7):855-63. DMFAMNH RU https://pubmed.ncbi.nlm.nih.gov/17921036 DMGTOIX DI DMGTOIX DMGTOIX DN A166 DMGTOIX MI TT6EO5L DMGTOIX MN Erbb2 tyrosine kinase receptor (HER2) DMGTOIX MT DTT DMGTOIX RN Clinical pipeline report, company report or official report of KLUS Pharma. DMGTOIX RU https://www.kluspharma.com/pipeline DMAPUZY DI DMAPUZY DMAPUZY DN AAV1-FS344 DMAPUZY MI TTM8I2X DMAPUZY MN Myostatin (MSTN) DMAPUZY MT DTT DMAPUZY MA Modulator DMAPUZY RN Follistatin Gene Delivery Enhances Muscle Growth and Strength in Nonhuman Primates. Sci Transl Med. 2009 November 11; 1(6): 6ra15. DMAPUZY RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2852878/ DMI27RF DI DMI27RF DMI27RF DN AAV-AQP1 DMI27RF MI TTSF1KH DMI27RF MN Aquaporin-1 (AQP1) DMI27RF MT DTT DMI27RF RN Clinical pipeline report, company report or official report of MeiraGTx. DMI27RF RU https://meiragtx.com/research-development/pipeline/ DMNZJAE DI DMNZJAE DMNZJAE DN AAV-CNGA3 DMNZJAE MI TTW0QOV DMNZJAE MN Cyclic nucleotide-gated channel alpha-3 (CNGA3) DMNZJAE MT DTT DMNZJAE RN Clinical pipeline report, company report or official report of MeiraGTx. DMNZJAE RU https://meiragtx.com/research-development/pipeline/ DM0CJAN DI DM0CJAN DM0CJAN DN AAV-CNGB3 DM0CJAN MI TT0LJCG DM0CJAN MN Cyclic nucleotide-gated channel beta-3 (CNGB3) DM0CJAN MT DTT DM0CJAN RN Clinical pipeline report, company report or official report of MeiraGTx. DM0CJAN RU https://meiragtx.com/research-development/pipeline/ DMAH6UJ DI DMAH6UJ DMAH6UJ DN AAV-RPE65 DMAH6UJ MI TTBOH16 DMAH6UJ MN Retinal pigment epithelium protein (RPE65) DMAH6UJ MT DTT DMAH6UJ RN Clinical pipeline report, company report or official report of MeiraGTx. DMAH6UJ RU https://meiragtx.com/research-development/pipeline/ DM7TF49 DI DM7TF49 DM7TF49 DN AAV-RPGR DM7TF49 MI TTHBDA9 DM7TF49 MN X-linked retinitis pigmentosa GTPase regulator (RPGR) DM7TF49 MT DTT DM7TF49 RN Clinical pipeline report, company report or official report of MeiraGTx. DM7TF49 RU https://meiragtx.com/research-development/pipeline/ DMDOXMN DI DMDOXMN DMDOXMN DN AB928 DMDOXMN MI TTM2AOE DMDOXMN MN Adenosine A2a receptor (ADORA2A) DMDOXMN MT DTT DMDOXMN MA Antagonist DMDOXMN RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMDOXMN RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DMDOXMN DI DMDOXMN DMDOXMN DN AB928 DMDOXMN MI TTNE7KG DMDOXMN MN Adenosine A2b receptor (ADORA2B) DMDOXMN MT DTT DMDOXMN MA Antagonist DMDOXMN RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMDOXMN RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DMUBLC3 DI DMUBLC3 DMUBLC3 DN ABO-101 DMUBLC3 MI TTDM6HZ DMUBLC3 MN Alpha-N-acetylglucosaminidase (NAGLU) DMUBLC3 MT DTT DMUBLC3 RN Clinical pipeline report, company report or official report of Abeona Therapeutics. DMUBLC3 RU https://www.abeonatherapeutics.com/science DMFJB35 DI DMFJB35 DMFJB35 DN ABO-102 DMFJB35 MI TTPJ2SH DMFJB35 MN N-sulphoglucosamine sulphohydrolase (SGSH) DMFJB35 MT DTT DMFJB35 RN Clinical pipeline report, company report or official report of Abeona Therapeutics. DMFJB35 RU https://www.abeonatherapeutics.com/science DM31NJU DI DM31NJU DM31NJU DN ABY-025 DM31NJU MI TT6EO5L DM31NJU MN Erbb2 tyrosine kinase receptor (HER2) DM31NJU MT DTT DM31NJU MA Enhancer DM31NJU RN Targeting of HER2-expressing tumors using 111In-ABY-025, a second-generation affibody molecule with a fundamentally reengineered scaffold. J Nucl Med. 2010 Jul;51(7):1131-8. DM31NJU RU https://pubmed.ncbi.nlm.nih.gov/20554729 DMIRGTZ DI DMIRGTZ DMIRGTZ DN ACHM-CNGA3 DMIRGTZ MI TTW0QOV DMIRGTZ MN Cyclic nucleotide-gated channel alpha-3 (CNGA3) DMIRGTZ MT DTT DMIRGTZ RN Clinical pipeline report, company report or official report of Applied Genetic Technologies. DMIRGTZ RU https://agtc.com/programs/achromatopsia/ DMC4ZQD DI DMC4ZQD DMC4ZQD DN ACHM-CNGB3 DMC4ZQD MI TT0LJCG DMC4ZQD MN Cyclic nucleotide-gated channel beta-3 (CNGB3) DMC4ZQD MT DTT DMC4ZQD RN Clinical pipeline report, company report or official report of Applied Genetic Technologies. DMC4ZQD RU https://agtc.com/programs/achromatopsia/ DM5YDSU DI DM5YDSU DM5YDSU DN ACI-24 DM5YDSU MI TTE4KHA DM5YDSU MN Amyloid beta A4 protein (APP) DM5YDSU MT DTT DM5YDSU RN Immunotherapy for Alzheimer's disease: hoops and hurdles. Mol Neurodegener. 2013; 8: 36. DM5YDSU RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4015631/ DM7IWTF DI DM7IWTF DM7IWTF DN ACP-319 DM7IWTF MI TTGM6VW DM7IWTF MN Tyrosine-protein kinase BTK (ATK) DM7IWTF MT DTT DM7IWTF MA Inhibitor DM7IWTF RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1948). DM7IWTF RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1948 DMEU86T DI DMEU86T DMEU86T DN ACT017 DMEU86T MI TTTJUVZ DMEU86T MN Platelet glycoprotein VI (GP6) DMEU86T MT DTT DMEU86T MA Inhibitor DMEU86T RN Safety and Tolerability, Pharmacokinetics, and Pharmacodynamics of ACT017, an Antiplatelet GPVI (Glycoprotein VI) Fab. Arterioscler Thromb Vasc Biol. 2019 May;39(5):956-964. DMEU86T RU https://pubmed.ncbi.nlm.nih.gov/31017822 DM4L28K DI DM4L28K DM4L28K DN Ad35-GRIN DM4L28K MI TTFGZB6 DM4L28K MN Human immunodeficiency virus GAG protein (HIV gag) DM4L28K MT DTT DM4L28K RN A phase I double blind, placebo-controlled, randomized study of a multigenic HIV-1 adenovirus subtype 35 vector vaccine in healthy uninfected adults. PLoS One. 2012;7(8):e41936. DM4L28K RU https://pubmed.ncbi.nlm.nih.gov/22870265 DM4L28K DI DM4L28K DM4L28K DN Ad35-GRIN DM4L28K MI TT4NXYM DM4L28K MN Human immunodeficiency virus Negative factor (HIV nef) DM4L28K MT DTT DM4L28K RN A phase I double blind, placebo-controlled, randomized study of a multigenic HIV-1 adenovirus subtype 35 vector vaccine in healthy uninfected adults. PLoS One. 2012;7(8):e41936. DM4L28K RU https://pubmed.ncbi.nlm.nih.gov/22870265 DM4L28K DI DM4L28K DM4L28K DN Ad35-GRIN DM4L28K MI TT84ETX DM4L28K MN Human immunodeficiency virus Reverse transcriptase (HIV RT) DM4L28K MT DTT DM4L28K RN A phase I double blind, placebo-controlled, randomized study of a multigenic HIV-1 adenovirus subtype 35 vector vaccine in healthy uninfected adults. PLoS One. 2012;7(8):e41936. DM4L28K RU https://pubmed.ncbi.nlm.nih.gov/22870265 DMEGPSW DI DMEGPSW DMEGPSW DN AdCh63 AMA1 DMEGPSW MI TTQZW34 DMEGPSW MN Plasmodium Apical membrane protein (Malaria AMA-1) DMEGPSW MT DTT DMEGPSW RN ClinicalTrials.gov (NCT01142765) Study to Assess Efficacy of New Malaria Vaccine Candidates AdCh63 AMA1, MVA AMA1, AdCh63 MSP1, MVA MSP1, AdCh63 ME-TRAP & MVA ME-TRAP. U.S. National Institutes of Health. DMEGPSW RU https://clinicaltrials.gov/ct2/show/NCT01142765 DMBGXH5 DI DMBGXH5 DMBGXH5 DN AdCh63-MSP1 DMBGXH5 MI TT68ZYJ DMBGXH5 MN Plasmodium Merozoite surface protein 1 (Malaria MSP-1) DMBGXH5 MT DTT DMBGXH5 RN Analysis of human B-cell responses following ChAd63-MVA MSP1 and AMA1 immunization and controlled malaria infection. Immunology. 2014 Apr;141(4):628-44. DMBGXH5 RU https://pubmed.ncbi.nlm.nih.gov/24303947 DMYOMSC DI DMYOMSC DMYOMSC DN Aderbasib DMYOMSC MI TTOMWSY DMYOMSC MN Mammalian disintegrin-metalloprotease (ADAM10) DMYOMSC MT DTT DMYOMSC MA Modulator DMYOMSC RN Company report (Incyte) DMYOMSC RU http://phx.corporate-ir.net/External.File?item=UGFyZW50SUQ9NDQwNjgzfENoaWxkSUQ9NDYyNTAzfFR5cGU9MQ==&t=1 DMYOMSC DI DMYOMSC DMYOMSC DN Aderbasib DMYOMSC MI TT6AZXG DMYOMSC MN TNF alpha converting enzyme (ADAM17) DMYOMSC MT DTT DMYOMSC MA Modulator DMYOMSC RN Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41. DMYOMSC RU https://www.ncbi.nlm.nih.gov/pubmed/15950434 DM87H0S DI DM87H0S DM87H0S DN ADG106 DM87H0S MI TTPW9LJ DM87H0S MN Co-stimulatory molecule 4-1BB (CD137) DM87H0S MT DTT DM87H0S MA Inhibitor DM87H0S RN Clinical pipeline report, company report or official report of Adagene. DM87H0S RU https://www.adagene.com/pipeline/adg106/ DMB19IO DI DMB19IO DMB19IO DN Ad-IL-12 DNA therapeutic DMB19IO MI TTGW72V DMB19IO MN Interleukin-12 beta (IL12B) DMB19IO MT DTT DMB19IO MA Modulator DMB19IO RN National Cancer Institute Drug Dictionary (drug id 710508). DMB19IO RU http://www.cancer.gov/publications/dictionaries/cancer-drug?cdrid=710508 DMOPVET DI DMOPVET DMOPVET DN ADXS-PSA DMOPVET MI TTS78AZ DMOPVET MN Prostate specific antigen (KLK3) DMOPVET MT DTT DMOPVET MA Modulator DMOPVET RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2373). DMOPVET RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2373 DMEOS5K DI DMEOS5K DMEOS5K DN AEE-788 DMEOS5K MI TTGJVQM DMEOS5K MN Fibroblast growth factor receptor 2 (FGFR2) DMEOS5K MT DTT DMEOS5K MA Inhibitor DMEOS5K RN A comparison of physicochemical property profiles of marketed oral drugs and orally bioavailable anti-cancer protein kinase inhibitors in clinical development. Curr Top Med Chem. 2007;7(14):1408-22. DMEOS5K RU https://pubmed.ncbi.nlm.nih.gov/17692029 DMEOS5K DI DMEOS5K DMEOS5K DN AEE-788 DMEOS5K MI TTST7KB DMEOS5K MN Fibroblast growth factor receptor 3 (FGFR3) DMEOS5K MT DTT DMEOS5K MA Inhibitor DMEOS5K RN A comparison of physicochemical property profiles of marketed oral drugs and orally bioavailable anti-cancer protein kinase inhibitors in clinical development. Curr Top Med Chem. 2007;7(14):1408-22. DMEOS5K RU https://pubmed.ncbi.nlm.nih.gov/17692029 DM2HRYD DI DM2HRYD DM2HRYD DN AEG35156 DM2HRYD MI TTK3WBU DM2HRYD MN XIAP messenger RNA (XIAP mRNA) DM2HRYD MT DTT DM2HRYD RN Teaming up to tackle RNAi delivery challenge. Nat Rev Drug Discov. 2009 Jul;8(7):525-6. DM2HRYD RU https://pubmed.ncbi.nlm.nih.gov/19568274 DMMNIBY DI DMMNIBY DMMNIBY DN Aflunov DMMNIBY MI TT3J5ZI DMMNIBY MN Cell mediated immunity response (CMIR) DMMNIBY MT DTT DMMNIBY RN Aflunov( ): a prepandemic influenza vaccine. Expert Rev Vaccines. 2012 Feb;11(2):145-57. DMMNIBY RU https://pubmed.ncbi.nlm.nih.gov/22309663 DMFTZX0 DI DMFTZX0 DMFTZX0 DN AFM24 DMFTZX0 MI TTGKNB4 DMFTZX0 MN Epidermal growth factor receptor (EGFR) DMFTZX0 MT DTT DMFTZX0 RN Clinical pipeline report, company report or official report of Affimed Therapeutics. DMFTZX0 RU https://www.affimed.com/rock-platform/pipeline/ DMFTZX0 DI DMFTZX0 DMFTZX0 DN AFM24 DMFTZX0 MI TTIFOC0 DMFTZX0 MN Immunoglobulin gamma Fc receptor IIIA (FCGR3A) DMFTZX0 MT DTT DMFTZX0 RN Clinical pipeline report, company report or official report of Affimed Therapeutics. DMFTZX0 RU https://www.affimed.com/rock-platform/pipeline/ DMRET3H DI DMRET3H DMRET3H DN AG-013958 DMRET3H MI TTVJ1D8 DMRET3H MN Vascular endothelial growth factor receptor (VEGFR) DMRET3H MT DTT DMRET3H MA Inhibitor DMRET3H RN Receptor Tyrosine Kinase Inhibitors AG013764 and AG013711 Reduce Choroidal Neovascularization in Rat Eye. Exp Eye Res. 2007 May; 84(5): 922-933. DMRET3H RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1995411/ DMEN2L7 DI DMEN2L7 DMEN2L7 DN AG019 DMEN2L7 MI TTT0Q1F DMEN2L7 MN Interleukin-10 (IL10) DMEN2L7 MT DTT DMEN2L7 RN ClinicalTrials.gov (NCT03751007) A Study to Assess the Safety and Tolerability of Different Doses of AG019 Administered Alone or in Combination With Teplizumab in Participants With Recently Diagnosed Type 1 Diabetes Mellitus (T1D). U.S. National Institutes of Health. DMEN2L7 RU https://clinicaltrials.gov/ct2/show/NCT03751007 DMAP5B4 DI DMAP5B4 DMAP5B4 DN AGEN1884 DMAP5B4 MI TTI2S1D DMAP5B4 MN Cytotoxic T-lymphocyte protein 4 (CTLA-4) DMAP5B4 MT DTT DMAP5B4 MA Antagonist DMAP5B4 RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMAP5B4 RU http://phrma-docs.phrma.org/files/dmfile/MID_Immuno-Oncology-2017_Drug-List1.pdf DMHZUF8 DI DMHZUF8 DMHZUF8 DN AGN-208397 DMHZUF8 MI TT6EO5L DMHZUF8 MN Erbb2 tyrosine kinase receptor (HER2) DMHZUF8 MT DTT DMHZUF8 MA Inhibitor DMHZUF8 RN New hope for dry AMD. Nat Rev Drug Discov. 2013 Jul;12(7):501-2. DMHZUF8 RU https://pubmed.ncbi.nlm.nih.gov/23812264 DMTS51C DI DMTS51C DMTS51C DN AGTC-501 DMTS51C MI TTHBDA9 DMTS51C MN X-linked retinitis pigmentosa GTPase regulator (RPGR) DMTS51C MT DTT DMTS51C RN ClinicalTrials.gov (NCT03316560) Safety and Efficacy of rAAV2tYF-GRK1-RPGR in Subjects With X-linked Retinitis Pigmentosa Caused by RPGR Mutations. U.S. National Institutes of Health. DMTS51C RU https://clinicaltrials.gov/ct2/show/NCT03316560 DMJVGIH DI DMJVGIH DMJVGIH DN AIGIV DMJVGIH MI TTRLPUB DMJVGIH MN Bacillus anthracis Protective antigen (Anthrax PA) DMJVGIH MT DTT DMJVGIH MA Modulator DMJVGIH RN Evaluation of intravenous anthrax immune globulin for treatment of inhalation anthrax. Antimicrob Agents Chemother. 2013 Nov;57(11):5684-92. DMJVGIH RU https://pubmed.ncbi.nlm.nih.gov/23979731 DML0GIU DI DML0GIU DML0GIU DN AIV001 DML0GIU MI TTVJ1D8 DML0GIU MN Vascular endothelial growth factor receptor (VEGFR) DML0GIU MT DTT DML0GIU MA Inhibitor DML0GIU RN Clinical pipeline report, company report or official report of AiViva BioPharma. DML0GIU RU https://aiviva.com/aiv001 DMNXLOT DI DMNXLOT DMNXLOT DN ALAMIFOVIR DMNXLOT MI TTMR83K DMNXLOT MN Hepatitis B virus Reverse transcriptase priming/DNA synthesis (HBV RTP/DS) DMNXLOT MT DTT DMNXLOT MA Modulator DMNXLOT RN Noncompetitive Inhibition of Hepatitis B Virus Reverse Transcriptase Protein Priming and DNA Synthesis by the Nucleoside Analog Clevudine. Correction in: Antimicrob Agents Chemother. 2013 November; 57(11): 5788. DMNXLOT RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3754288/ DMGQX0U DI DMGQX0U DMGQX0U DN ALX148 DMGQX0U MI TT28S46 DMGQX0U MN Leukocyte surface antigen CD47 (CD47) DMGQX0U MT DTT DMGQX0U MA Inhibitor DMGQX0U RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMGQX0U RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DMEF4L5 DI DMEF4L5 DMEF4L5 DN AMG888/U3-1287 DMEF4L5 MI TTDC8N2 DMEF4L5 MN Erbb3 tyrosine kinase receptor (Erbb-3) DMEF4L5 MT DTT DMEF4L5 MA Modulator DMEF4L5 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1798). DMEF4L5 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1798 DM7RNKM DI DM7RNKM DM7RNKM DN AMT-060 DM7RNKM MI TTFEZ5Q DM7RNKM MN Coagulation factor IX (F9) DM7RNKM MT DTT DM7RNKM MA Modulator DM7RNKM RN Phase I/II clinical trial of AMT-060 for treating hemophilia B. uniQure N.V. DM7RNKM RU http://www.biocentury.com/products/amt-060 DMR9H6B DI DMR9H6B DMR9H6B DN AMXI 5001 DMR9H6B MI TTU1SOM DMR9H6B MN Microtubule polymerization (MicroTu poly) DMR9H6B MT DTT DMR9H6B MA Inhibitor DMR9H6B RN AMXI-5001, a novel dual parp1/2 and microtubule polymerization inhibitor for the treatment of human cancers. Am J Cancer Res. 2020 Aug 1;10(8):2649-2676. DMR9H6B RU https://pubmed.ncbi.nlm.nih.gov/32905466 DMR9H6B DI DMR9H6B DMR9H6B DN AMXI 5001 DMR9H6B MI TTVDSZ0 DMR9H6B MN Poly [ADP-ribose] polymerase 1 (PARP1) DMR9H6B MT DTT DMR9H6B MA Inhibitor DMR9H6B RN AMXI-5001, a novel dual parp1/2 and microtubule polymerization inhibitor for the treatment of human cancers. Am J Cancer Res. 2020 Aug 1;10(8):2649-2676. DMR9H6B RU https://pubmed.ncbi.nlm.nih.gov/32905466 DMR9H6B DI DMR9H6B DMR9H6B DN AMXI 5001 DMR9H6B MI TTQ4V96 DMR9H6B MN Poly [ADP-ribose] polymerase 2 (PARP2) DMR9H6B MT DTT DMR9H6B MA Inhibitor DMR9H6B RN AMXI-5001, a novel dual parp1/2 and microtubule polymerization inhibitor for the treatment of human cancers. Am J Cancer Res. 2020 Aug 1;10(8):2649-2676. DMR9H6B RU https://pubmed.ncbi.nlm.nih.gov/32905466 DMDHJNV DI DMDHJNV DMDHJNV DN Annamycin DMDHJNV MI TTCGY2K DMDHJNV MN DNA topoisomerase II alpha (TOP2A) DMDHJNV MT DTT DMDHJNV RN Effect of structural modification at the 4, 3', and 2' positions of doxorubicin on topoisomerase II poisoning, apoptosis, and cytotoxicity in human melanoma cells. Arch Immunol Ther Exp (Warsz). May-Jun 2007;55(3):193-8. DMDHJNV RU https://pubmed.ncbi.nlm.nih.gov/17557149 DM4D3YF DI DM4D3YF DM4D3YF DN Anti-BCMA CAR-T cells DM4D3YF MI TTZ3P4W DM4D3YF MN B-cell maturation protein (TNFRSF17) DM4D3YF MT DTT DM4D3YF MA CAR-T-Cell-Therapy DM4D3YF RN ClinicalTrials.gov (NCT03638206) Autologous CAR-T/TCR-T Cell Immunotherapy for Malignancies DM4D3YF RU https://clinicaltrials.gov/ct2/show/NCT03638206 DMZ18IO DI DMZ18IO DMZ18IO DN Anti-BCMA-CAR-transduced T cells DMZ18IO MI TTZ3P4W DMZ18IO MN B-cell maturation protein (TNFRSF17) DMZ18IO MT DTT DMZ18IO MA CAR-T-Cell-Therapy DMZ18IO RN ClinicalTrials.gov (NCT02954445) A Clinical Research of BCMA-Targeted CAR-T in B Cell Malignancies DMZ18IO RU https://clinicaltrials.gov/ct2/show/NCT02954445 DMFV6TY DI DMFV6TY DMFV6TY DN Anti-CD123-CAR-transduced T cells DMFV6TY MI TTENHJ0 DMFV6TY MN Interleukin 3 receptor alpha (IL3RA) DMFV6TY MT DTT DMFV6TY MA CAR-T-Cell-Therapy DMFV6TY RN ClinicalTrials.gov (NCT02937103) A Clinical Research of CD123-Targeted CAR-T in Myeloid Malignancies DMFV6TY RU https://clinicaltrials.gov/ct2/show/NCT02937103 DMLFB25 DI DMLFB25 DMLFB25 DN Anti-CD19 and Anti-CD20 CAR-T Cells DMLFB25 MI TTW640A DMLFB25 MN B-lymphocyte surface antigen B4 (CD19) DMLFB25 MT DTT DMLFB25 MA CAR-T-Cell-Therapy(Dual specific) DMLFB25 RN ClinicalTrials.gov (NCT03207178) Sequential Infusion of Anti-CD19 and Anti-CD20 CAR-T Cells Against Relapsed and Refractory B-cell Lymphoma DMLFB25 RU https://clinicaltrials.gov/ct2/show/NCT03207178 DMLFB25 DI DMLFB25 DMLFB25 DN Anti-CD19 and Anti-CD20 CAR-T Cells DMLFB25 MI TTUE541 DMLFB25 MN Leukocyte surface antigen Leu-16 (CD20) DMLFB25 MT DTT DMLFB25 MA CAR-T-Cell-Therapy(Dual specific) DMLFB25 RN ClinicalTrials.gov (NCT03207178) Sequential Infusion of Anti-CD19 and Anti-CD20 CAR-T Cells Against Relapsed and Refractory B-cell Lymphoma DMLFB25 RU https://clinicaltrials.gov/ct2/show/NCT03207178 DMS326R DI DMS326R DMS326R DN Anti-CD19 CAR T cells DMS326R MI TTW640A DMS326R MN B-lymphocyte surface antigen B4 (CD19) DMS326R MT DTT DMS326R MA CAR-T-Cell-Therapy DMS326R RN ClinicalTrials.gov (NCT02842138) Autologous CD19 CAR T Cells in Relapsed or Refractory B-cell Lymphoma DMS326R RU https://clinicaltrials.gov/ct2/show/NCT02842138 DMHSLVJ DI DMHSLVJ DMHSLVJ DN Anti-CD19 CAR transduced T cells DMHSLVJ MI TTW640A DMHSLVJ MN B-lymphocyte surface antigen B4 (CD19) DMHSLVJ MT DTT DMHSLVJ MA CAR-T-Cell-Therapy DMHSLVJ RN ClinicalTrials.gov (NCT03191773) A Study of Anti-CD19 CAR-T Cell Immunotherapy for Refractory /Relapsed B Cell Malignancies DMHSLVJ RU https://clinicaltrials.gov/ct2/show/NCT03191773 DM04HNB DI DM04HNB DM04HNB DN Anti-CD19 CAR-T DM04HNB MI TTW640A DM04HNB MN B-lymphocyte surface antigen B4 (CD19) DM04HNB MT DTT DM04HNB MA CAR-T-Cell-Therapy DM04HNB RN ClinicalTrials.gov (NCT02685670) Competitive Transfer of CD19-TCRz-CD28 and CD19-TCRz-CD137 CAR-T Cells for B-cell Leukemia/Lymphoma DM04HNB RU https://clinicaltrials.gov/ct2/show/NCT02685670 DMDRYZK DI DMDRYZK DMDRYZK DN Anti-CD19 CAR-T cells DMDRYZK MI TTW640A DMDRYZK MN B-lymphocyte surface antigen B4 (CD19) DMDRYZK MT DTT DMDRYZK MA CAR-T-Cell-Therapy DMDRYZK RN ClinicalTrials.gov (NCT02851589) Study Evaluating the Efficacy and Safety of PCAR-019 in CD19 Positive Relapsed or Refractory Leukemia and Lymphoma DMDRYZK RU https://clinicaltrials.gov/ct2/show/NCT02851589 DMSFEOC DI DMSFEOC DMSFEOC DN Anti-CD19 CAR-T cells DMSFEOC MI TTW640A DMSFEOC MN B-lymphocyte surface antigen B4 (CD19) DMSFEOC MT DTT DMSFEOC MA CAR-T-Cell-Therapy DMSFEOC RN ClinicalTrials.gov (NCT02782351) Humanized CAR-T Therapy for Treatment of B Cell Malignancy DMSFEOC RU https://clinicaltrials.gov/ct2/show/NCT02782351 DM1EH9D DI DM1EH9D DM1EH9D DN Anti-CD19 CAR-T cells DM1EH9D MI TTW640A DM1EH9D MN B-lymphocyte surface antigen B4 (CD19) DM1EH9D MT DTT DM1EH9D MA CAR-T-Cell-Therapy DM1EH9D RN ClinicalTrials.gov (NCT03638206) Autologous CAR-T/TCR-T Cell Immunotherapy for Malignancies DM1EH9D RU https://clinicaltrials.gov/ct2/show/NCT03638206 DM92CUG DI DM92CUG DM92CUG DN Anti-CD19 CAR-T cells DM92CUG MI TTW640A DM92CUG MN B-lymphocyte surface antigen B4 (CD19) DM92CUG MT DTT DM92CUG MA CAR-T-Cell-Therapy DM92CUG RN ClinicalTrials.gov (NCT03366324) Anti-CD19 CAR-T Therapy Combine With HSCT to Treat MRD+ B-cell Malignancies DM92CUG RU https://clinicaltrials.gov/ct2/show/NCT03366324 DMMUSHR DI DMMUSHR DMMUSHR DN Anti-CD19/22-CAR vector-transduced T cells DMMUSHR MI TTM6QSK DMMUSHR MN B-cell receptor CD22 (CD22) DMMUSHR MT DTT DMMUSHR MA CAR-T-Cell-Therapy(Dual specific) DMMUSHR RN ClinicalTrials.gov (NCT03185494) Treatment of Relapsed and/or Chemotherapy Refractory B-cell Malignancy by Tandem CAR T Cells Targeting CD19 and CD22 DMMUSHR RU https://clinicaltrials.gov/ct2/show/NCT03185494 DMMUSHR DI DMMUSHR DMMUSHR DN Anti-CD19/22-CAR vector-transduced T cells DMMUSHR MI TTW640A DMMUSHR MN B-lymphocyte surface antigen B4 (CD19) DMMUSHR MT DTT DMMUSHR MA CAR-T-Cell-Therapy(Dual specific) DMMUSHR RN ClinicalTrials.gov (NCT03185494) Treatment of Relapsed and/or Chemotherapy Refractory B-cell Malignancy by Tandem CAR T Cells Targeting CD19 and CD22 DMMUSHR RU https://clinicaltrials.gov/ct2/show/NCT03185494 DM1WB8H DI DM1WB8H DM1WB8H DN Anti-CD19-CAR PBL DM1WB8H MI TTW640A DM1WB8H MN B-lymphocyte surface antigen B4 (CD19) DM1WB8H MT DTT DM1WB8H MA CAR-T-Cell-Therapy DM1WB8H RN ClinicalTrials.gov (NCT00924326) CAR T Cell Receptor Immunotherapy for Patients With B-cell Lymphoma DM1WB8H RU https://clinicaltrials.gov/ct2/show/NCT00924326 DMQXU4C DI DMQXU4C DMQXU4C DN Anti-CD19-CAR vector-transduced T cells DMQXU4C MI TTW640A DMQXU4C MN B-lymphocyte surface antigen B4 (CD19) DMQXU4C MT DTT DMQXU4C MA CAR-T-Cell-Therapy DMQXU4C RN ClinicalTrials.gov (NCT02081937) CART-19 Immunotherapy in Mantle Cell Lymphoma DMQXU4C RU https://clinicaltrials.gov/ct2/show/NCT02081937 DMNTP23 DI DMNTP23 DMNTP23 DN Anti-CD19-CAR-T cells DMNTP23 MI TTW640A DMNTP23 MN B-lymphocyte surface antigen B4 (CD19) DMNTP23 MT DTT DMNTP23 MA CAR-T-Cell-Therapy DMNTP23 RN ClinicalTrials.gov (NCT02672501) A Study to Assess CD19-targeted Immunotherapy T Cells in Patients With Relapsed or Refractory CD19+ B Cell Leukemia DMNTP23 RU https://clinicaltrials.gov/ct2/show/NCT02672501 DM4WEZL DI DM4WEZL DM4WEZL DN Anti-CD20 CAR-T cells DM4WEZL MI TTW640A DM4WEZL MN B-lymphocyte surface antigen B4 (CD19) DM4WEZL MT DTT DM4WEZL MA CAR-T-Cell-Therapy(Dual specific) DM4WEZL RN ClinicalTrials.gov (NCT02737085) the Sequential Therapy of CD19-targeted and CD20-targeted CAR-T Cell Therapy for Diffuse Large B Cell Lymphoma(DLBCL) DM4WEZL RU https://clinicaltrials.gov/ct2/show/NCT02737085 DM4WEZL DI DM4WEZL DM4WEZL DN Anti-CD20 CAR-T cells DM4WEZL MI TTUE541 DM4WEZL MN Leukocyte surface antigen Leu-16 (CD20) DM4WEZL MT DTT DM4WEZL MA CAR-T-Cell-Therapy(Dual specific) DM4WEZL RN ClinicalTrials.gov (NCT02737085) the Sequential Therapy of CD19-targeted and CD20-targeted CAR-T Cell Therapy for Diffuse Large B Cell Lymphoma(DLBCL) DM4WEZL RU https://clinicaltrials.gov/ct2/show/NCT02737085 DMCDUJY DI DMCDUJY DMCDUJY DN Anti-CD20-CAR vector-transduced autologous T cells DMCDUJY MI TTUE541 DMCDUJY MN Leukocyte surface antigen Leu-16 (CD20) DMCDUJY MT DTT DMCDUJY MA CAR-T-Cell-Therapy DMCDUJY RN ClinicalTrials.gov (NCT01735604) Genetically Engineered Lymphocyte Therapy in Treating Patients With Lymphoma That is Resistant or Refractory to Chemotherapy DMCDUJY RU https://clinicaltrials.gov/ct2/show/NCT01735604 DMXMK30 DI DMXMK30 DMXMK30 DN Anti-CD20-CAR-transduced T cells DMXMK30 MI TTUE541 DMXMK30 MN Leukocyte surface antigen Leu-16 (CD20) DMXMK30 MT DTT DMXMK30 MA CAR-T-Cell-Therapy DMXMK30 RN ClinicalTrials.gov (NCT02710149) A Clinical Research of CD20-Targeted CAR-T in B Cell Malignancies DMXMK30 RU https://clinicaltrials.gov/ct2/show/NCT02710149 DMY6U8R DI DMY6U8R DMY6U8R DN Anti-CD22 CAR-T cells DMY6U8R MI TTM6QSK DMY6U8R MN B-cell receptor CD22 (CD22) DMY6U8R MT DTT DMY6U8R MA CAR-T-Cell-Therapy DMY6U8R RN ClinicalTrials.gov (NCT03638206) Autologous CAR-T/TCR-T Cell Immunotherapy for Malignancies DMY6U8R RU https://clinicaltrials.gov/ct2/show/NCT03638206 DMTO9VF DI DMTO9VF DMTO9VF DN Anti-CD22-CAR-transduced T cells DMTO9VF MI TTM6QSK DMTO9VF MN B-cell receptor CD22 (CD22) DMTO9VF MT DTT DMTO9VF MA CAR-T-Cell-Therapy DMTO9VF RN ClinicalTrials.gov (NCT03262298) Anti-CD22 CAR-T Cell Therapy Targeting B Cell Malignancies DMTO9VF RU https://clinicaltrials.gov/ct2/show/NCT03262298 DM8139V DI DM8139V DM8139V DN Anti-CD30 CAR T cells DM8139V MI TT2GM5R DM8139V MN Lymphocyte activation antigen CD30 (TNFRSF8) DM8139V MT DTT DM8139V MA CAR-T-Cell-Therapy DM8139V RN ClinicalTrials.gov (NCT02274584) CAR T Cells Targeting CD30 Positive Lymphomas (4SCAR30273) DM8139V RU https://clinicaltrials.gov/ct2/show/NCT02274584 DMTZSPJ DI DMTZSPJ DMTZSPJ DN Anti-CD30-CAR-transduced T cells DMTZSPJ MI TT2GM5R DMTZSPJ MN Lymphocyte activation antigen CD30 (TNFRSF8) DMTZSPJ MT DTT DMTZSPJ MA CAR-T-Cell-Therapy DMTZSPJ RN ClinicalTrials.gov (NCT02958410) A Clinical Research of CD30-Targeted CAR-T in Lymphocyte Malignancies DMTZSPJ RU https://clinicaltrials.gov/ct2/show/NCT02958410 DM9NPF6 DI DM9NPF6 DM9NPF6 DN Anti-CD33 CAR-T cells DM9NPF6 MI TTJVYO3 DM9NPF6 MN Myeloid cell surface antigen CD33 (CD33) DM9NPF6 MT DTT DM9NPF6 MA CAR-T-Cell-Therapy DM9NPF6 RN ClinicalTrials.gov (NCT03638206) Autologous CAR-T/TCR-T Cell Immunotherapy for Malignancies DM9NPF6 RU https://clinicaltrials.gov/ct2/show/NCT03638206 DMTVXBY DI DMTVXBY DMTVXBY DN Anti-CD38 CAR-T cells DMTVXBY MI TTPURFN DMTVXBY MN Cyclic ADP-ribose hydrolase 1 (CD38) DMTVXBY MT DTT DMTVXBY MA CAR-T-Cell-Therapy DMTVXBY RN ClinicalTrials.gov (NCT03638206) Autologous CAR-T/TCR-T Cell Immunotherapy for Malignancies DMTVXBY RU https://clinicaltrials.gov/ct2/show/NCT03638206 DMV5H0S DI DMV5H0S DMV5H0S DN Anti-C-met CAR-T cells DMV5H0S MI TTNDSF4 DMV5H0S MN Proto-oncogene c-Met (MET) DMV5H0S MT DTT DMV5H0S MA CAR-T-Cell-Therapy DMV5H0S RN ClinicalTrials.gov (NCT03638206) Autologous CAR-T/TCR-T Cell Immunotherapy for Malignancies DMV5H0S RU https://clinicaltrials.gov/ct2/show/NCT03638206 DMYKZB3 DI DMYKZB3 DMYKZB3 DN Anti-DR5 cells DMYKZB3 MI TTW20TU DMYKZB3 MN TRAIL receptor 2 (TRAIL-R2) DMYKZB3 MT DTT DMYKZB3 MA CAR-T-Cell-Therapy DMYKZB3 RN ClinicalTrials.gov (NCT03638206) Autologous CAR-T/TCR-T Cell Immunotherapy for Malignancies DMYKZB3 RU https://clinicaltrials.gov/ct2/show/NCT03638206 DM8EAGV DI DM8EAGV DM8EAGV DN Anti-EGFR V III CAR-T cells DM8EAGV MI TTZ6B2I DM8EAGV MN Epidermal growth factor receptor variant III (EGFR vIII) DM8EAGV MT DTT DM8EAGV MA CAR-T-Cell-Therapy DM8EAGV RN ClinicalTrials.gov (NCT03638206) Autologous CAR-T/TCR-T Cell Immunotherapy for Malignancies DM8EAGV RU https://clinicaltrials.gov/ct2/show/NCT03638206 DMDKTYU DI DMDKTYU DMDKTYU DN Anti-EGFRvIII CAR transduced PBL DMDKTYU MI TTZ6B2I DMDKTYU MN Epidermal growth factor receptor variant III (EGFR vIII) DMDKTYU MT DTT DMDKTYU MA CAR-T-Cell-Therapy DMDKTYU RN ClinicalTrials.gov (NCT01454596) CAR T Cell Receptor Immunotherapy Targeting EGFRvIII for Patients With Malignant Gliomas Expressing EGFRvIII. U.S. National Institutes of Health. DMDKTYU RU https://clinicaltrials.gov/ct2/show/NCT01454596 DM8ENKS DI DM8ENKS DM8ENKS DN Anti-Factor D DM8ENKS MI TT8D13I DM8ENKS MN Complement factor D (CFD) DM8ENKS MT DTT DM8ENKS RN Association for Research in Vision and Ophthalmology (ARVO)--2010 Annual Meeting. For Sight: The Future of Eye and Vision Research--part 1. IDrugs. 2010 Jul;13(7):427-9. DM8ENKS RU https://pubmed.ncbi.nlm.nih.gov/20582862 DMQD6B9 DI DMQD6B9 DMQD6B9 DN Anti-HER2 CAR-T DMQD6B9 MI TT6EO5L DMQD6B9 MN Erbb2 tyrosine kinase receptor (HER2) DMQD6B9 MT DTT DMQD6B9 MA CAR-T-Cell-Therapy DMQD6B9 RN ClinicalTrials.gov (NCT02713984) A Clinical Research of CAR T Cells Targeting HER2 Positive Cancer DMQD6B9 RU https://clinicaltrials.gov/ct2/show/NCT02713984 DMQZJ3B DI DMQZJ3B DMQZJ3B DN Anti-HIV ribozyme therapy DMQZJ3B MI TTT3ZC9 DMQZJ3B MN Human immunodeficiency virus Tat protein (HIV tat) DMQZJ3B MT DTT DMQZJ3B MA Modulator DMQZJ3B RN Clinical gene therapy research utilizing ribozymes: application to the treatment of HIV/AIDS. Methods Mol Biol. 2004;252:581-98. DMQZJ3B RU https://pubmed.ncbi.nlm.nih.gov/15017082 DMXI03L DI DMXI03L DMXI03L DN Anti-mesothelin CAR transduced PBL DMXI03L MI TT4RXME DMXI03L MN Mesothelin (MSLN) DMXI03L MT DTT DMXI03L MA CAR-T-Cell-Therapy DMXI03L RN ClinicalTrials.gov (NCT01583686) CAR T Cell Receptor Immunotherapy Targeting Mesothelin for Patients With Metastatic Cancer DMXI03L RU https://clinicaltrials.gov/ct2/show/NCT01583686 DM4NMBW DI DM4NMBW DM4NMBW DN Anti-Mesothelin CAR-T cells DM4NMBW MI TT4RXME DM4NMBW MN Mesothelin (MSLN) DM4NMBW MT DTT DM4NMBW MA CAR-T-Cell-Therapy DM4NMBW RN ClinicalTrials.gov (NCT03638206) Autologous CAR-T/TCR-T Cell Immunotherapy for Malignancies DM4NMBW RU https://clinicaltrials.gov/ct2/show/NCT03638206 DM0C1IX DI DM0C1IX DM0C1IX DN Anti-MUC1 CAR T Cells DM0C1IX MI TTBHFYQ DM0C1IX MN Mucin-1 (MUC1) DM0C1IX MT DTT DM0C1IX MA CAR-T-Cell-Therapy DM0C1IX RN ClinicalTrials.gov (NCT02587689) Phase I/II Study of Anti-Mucin1 (MUC1) CAR T Cells for Patients With MUC1+ Advanced Refractory Solid Tumor DM0C1IX RU https://clinicaltrials.gov/ct2/show/NCT02587689 DMDHKN1 DI DMDHKN1 DMDHKN1 DN Anti-MUC1 CAR T Cells DMDHKN1 MI TTBHFYQ DMDHKN1 MN Mucin-1 (MUC1) DMDHKN1 MT DTT DMDHKN1 MA CAR-T-Cell-Therapy DMDHKN1 RN ClinicalTrials.gov (NCT03525782) Anti-MUC1 CAR T Cells and PD-1 Knockout Engineered T Cells for NSCLC DMDHKN1 RU https://clinicaltrials.gov/ct2/show/NCT03525782 DMXYOTP DI DMXYOTP DMXYOTP DN Anti-MUC1 CAR-T cells DMXYOTP MI TTBHFYQ DMXYOTP MN Mucin-1 (MUC1) DMXYOTP MT DTT DMXYOTP MA CAR-T-Cell-Therapy DMXYOTP RN ClinicalTrials.gov (NCT03706326) CAR T and PD-1 Knockout Engineered T Cells for Esophageal Cancer DMXYOTP RU https://clinicaltrials.gov/ct2/show/NCT03706326 DMTQIB2 DI DMTQIB2 DMTQIB2 DN Anti-MUC1 CAR-T cells DMTQIB2 MI TTBHFYQ DMTQIB2 MN Mucin-1 (MUC1) DMTQIB2 MT DTT DMTQIB2 MA CAR-T-Cell-Therapy DMTQIB2 RN ClinicalTrials.gov (NCT02617134) CAR-T Cell Immunotherapy in MUC1 Positive Solid Tumor DMTQIB2 RU https://clinicaltrials.gov/ct2/show/NCT02617134 DM26VCZ DI DM26VCZ DM26VCZ DN Anti-NY-ESO-1 CAR-T cells DM26VCZ MI TTE5ITK DM26VCZ MN Cancer/testis antigen 1 (NY-ESO-1) DM26VCZ MT DTT DM26VCZ MA CAR-T-Cell-Therapy DM26VCZ RN ClinicalTrials.gov (NCT03638206) Autologous CAR-T/TCR-T Cell Immunotherapy for Malignancies DM26VCZ RU https://clinicaltrials.gov/ct2/show/NCT03638206 DM2910G DI DM2910G DM2910G DN Anti-VEGFR2 CD8 cell therapy DM2910G MI TTMHA6L DM2910G MN T-cell surface glycoprotein CD8 (CD8) DM2910G MT DTT DM2910G MA Modulator DM2910G RN Vascular normalizing doses of antiangiogenic treatment reprogram the immunosuppressive tumor microenvironment and enhance immunotherapy. Proc Natl Acad Sci U S A. 2012 Oct 23;109(43):17561-6. DM2910G RU https://pubmed.ncbi.nlm.nih.gov/23045683 DM2910G DI DM2910G DM2910G DN Anti-VEGFR2 CD8 cell therapy DM2910G MI TTUTJGQ DM2910G MN Vascular endothelial growth factor receptor 2 (KDR) DM2910G MT DTT DM2910G MA Modulator DM2910G RN Vascular normalizing doses of antiangiogenic treatment reprogram the immunosuppressive tumor microenvironment and enhance immunotherapy. Proc Natl Acad Sci U S A. 2012 Oct 23;109(43):17561-6. DM2910G RU https://pubmed.ncbi.nlm.nih.gov/23045683 DMXU98C DI DMXU98C DMXU98C DN AO-176 DMXU98C MI TT28S46 DMXU98C MN Leukocyte surface antigen CD47 (CD47) DMXU98C MT DTT DMXU98C MA Inhibitor DMXU98C RN Development of AO-176, a Next-Generation Humanized Anti-CD47 Antibody with Novel Anticancer Properties and Negligible Red Blood Cell Binding. Mol Cancer Ther. 2020 Mar;19(3):835-846. DMXU98C RU https://pubmed.ncbi.nlm.nih.gov/31879362 DMBGA35 DI DMBGA35 DMBGA35 DN AP-1030 DMBGA35 MI TT0MV2T DMBGA35 MN Melanocortin receptor 1 (MC1R) DMBGA35 MT DTT DMBGA35 MA Modulator DMBGA35 RN Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41. DMBGA35 RU https://www.ncbi.nlm.nih.gov/pubmed/15950434 DMBGA35 DI DMBGA35 DMBGA35 DN AP-1030 DMBGA35 MI TTD0CIQ DMBGA35 MN Melanocortin receptor 4 (MC4R) DMBGA35 MT DTT DMBGA35 MA Modulator DMBGA35 RN Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41. DMBGA35 RU https://www.ncbi.nlm.nih.gov/pubmed/15950434 DM2LU8M DI DM2LU8M DM2LU8M DN AP1903 DM2LU8M MI TTMW94E DM2LU8M MN FK506-binding protein 1A (FKBP1A) DM2LU8M MT DTT DM2LU8M MA Modulator DM2LU8M RN Using gene transfer to circumvent off-target effects. Gene Ther. 2008 May;15(10):759-64. DM2LU8M RU https://pubmed.ncbi.nlm.nih.gov/18356813 DMJLMEF DI DMJLMEF DMJLMEF DN AP-30663 DMJLMEF MI TTKU9YD DMJLMEF MN Calcium-activated potassium channel KCa2 (KCNN) DMJLMEF MT DTT DMJLMEF MA Inhibitor DMJLMEF RN Antibodies and venom peptides: new modalities for ion channels. Nat Rev Drug Discov. 2019 May;18(5):339-357. DMJLMEF RU https://pubmed.ncbi.nlm.nih.gov/30728472 DM71I53 DI DM71I53 DM71I53 DN APC-100 DM71I53 MI TTS64P2 DM71I53 MN Androgen receptor (AR) DM71I53 MT DTT DM71I53 MA Inhibitor DM71I53 RN 2011 Pipeline of Adamis Pharmaceuticals. DM71I53 RU http://www.adamispharmaceuticals.com/ DM8O3R9 DI DM8O3R9 DM8O3R9 DN APG-1252 DM8O3R9 MI TTJGNVC DM8O3R9 MN Apoptosis regulator Bcl-2 (BCL-2) DM8O3R9 MT DTT DM8O3R9 MA Inhibitor DM8O3R9 RN Bcl-2/Bcl-xl inhibitor APG-1252-M1 is a promising therapeutic strategy for gastric carcinoma. Cancer Med. 2020 Jun;9(12):4197-4206. DM8O3R9 RU https://pubmed.ncbi.nlm.nih.gov/32346976 DM8O3R9 DI DM8O3R9 DM8O3R9 DN APG-1252 DM8O3R9 MI TTU1E82 DM8O3R9 MN Apoptosis regulator Bcl-xL (BCL-xL) DM8O3R9 MT DTT DM8O3R9 MA Inhibitor DM8O3R9 RN Bcl-2/Bcl-xl inhibitor APG-1252-M1 is a promising therapeutic strategy for gastric carcinoma. Cancer Med. 2020 Jun;9(12):4197-4206. DM8O3R9 RU https://pubmed.ncbi.nlm.nih.gov/32346976 DMPWBM2 DI DMPWBM2 DMPWBM2 DN APG-2575 DMPWBM2 MI TTJGNVC DMPWBM2 MN Apoptosis regulator Bcl-2 (BCL-2) DMPWBM2 MT DTT DMPWBM2 MA Inhibitor DMPWBM2 RN A Novel BCL-2 Inhibitor APG-2575 Exerts Synthetic Lethality With BTK or MDM2-p53 Inhibitor in Diffuse Large B-Cell Lymphoma. Oncol Res. 2020 Sep 1;28(4):331-344. DMPWBM2 RU https://pubmed.ncbi.nlm.nih.gov/32093809 DMV7Q6X DI DMV7Q6X DMV7Q6X DN APN-201 DMV7Q6X MI TT6RVLG DMV7Q6X MN Superoxide dismutase Cu-Zn (SOD Cu-Zn) DMV7Q6X MT DTT DMV7Q6X MA Modulator DMV7Q6X RN Peyronie's disease: a critical appraisal of current diagnosis and treatment. Int J Impot Res. 2008 Sep-Oct;20(5):445-59. DMV7Q6X RU https://pubmed.ncbi.nlm.nih.gov/18650828 DM76S3X DI DM76S3X DM76S3X DN ARO-HBV DM76S3X MI TT43YWN DM76S3X MN Hepatitis B virus messenger RNA (HBV mRNA) DM76S3X MT DTT DM76S3X MA Inhibitor DM76S3X RN Clinical pipeline report, company report or official report of Arrowhead Pharmaceuticals. DM76S3X RU https://arrowheadpharma.com/pipeline/ DMI17NX DI DMI17NX DMI17NX DN ART621 DMI17NX MI TTF8CQI DMI17NX MN Tumor necrosis factor (TNF) DMI17NX MT DTT DMI17NX MA Inhibitor DMI17NX RN Emerging drugs for psoriasis. Expert Opin Emerg Drugs. 2009 Mar;14(1):145-63. DMI17NX RU https://pubmed.ncbi.nlm.nih.gov/19249988 DMYCID5 DI DMYCID5 DMYCID5 DN ARV-110 DMYCID5 MI TTS64P2 DMYCID5 MN Androgen receptor (AR) DMYCID5 MT DTT DMYCID5 MA Degrader DMYCID5 RN Clinical pipeline report, company report or official report of Arvinas. DMYCID5 RU https://www.arvinas.com/pipeline-programs/androgen-receptor DM276Y8 DI DM276Y8 DM276Y8 DN ARV-471 DM276Y8 MI TTS64P2 DM276Y8 MN Androgen receptor (AR) DM276Y8 MT DTT DM276Y8 MA Degrader DM276Y8 RN Targeting estrogen receptor alpha for degradation with PROTACs: A promising approach to overcome endocrine resistance. Eur J Med Chem. 2020 Nov 15;206:112689. DM276Y8 RU https://pubmed.ncbi.nlm.nih.gov/32829249 DMVNCSK DI DMVNCSK DMVNCSK DN ASC-101 DMVNCSK MI TT3C1VN DMVNCSK MN Enzyme unspecific (Enz) DMVNCSK MT DTT DMVNCSK MA Modulator DMVNCSK RN ClinicalTrials.gov (NCT01983761) Study of ASC-101 in Patients With Hematologic Malignancies Who Receive Dual-cord Umbilical Cord Blood Transplantation. U.S. National Institutes of Health. DMVNCSK RU https://clinicaltrials.gov/ct2/show/NCT01983761 DM8V0UL DI DM8V0UL DM8V0UL DN ASP-9521 DM8V0UL MI TT5ZWB6 DM8V0UL MN Dihydrodiol dehydrogenase type I (AKR1C3) DM8V0UL MT DTT DM8V0UL MA Modulator DM8V0UL RN Safety, tolerability and anti-tumour activity of the androgen biosynthesis inhibitor ASP9521 in patients with metastatic castration-resistant prostate cancer: multi-centre phase I/II study. Invest New Drugs. 2014 Oct;32(5):995-1004. DM8V0UL RU https://pubmed.ncbi.nlm.nih.gov/24771350 DMVZXIA DI DMVZXIA DMVZXIA DN ASTX029 DMVZXIA MI TT1MG9E DMVZXIA MN Extracellular signal-regulated kinase 1 (ERK1) DMVZXIA MT DTT DMVZXIA MA Inhibitor DMVZXIA RN Clinical pipeline report, company report or official report of Astex Pharmaceuticals. DMVZXIA RU https://astx.com/research-development/clinical-pipeline/ DMVZXIA DI DMVZXIA DMVZXIA DN ASTX029 DMVZXIA MI TT4TQBX DMVZXIA MN Extracellular signal-regulated kinase 2 (ERK2) DMVZXIA MT DTT DMVZXIA MA Inhibitor DMVZXIA RN Clinical pipeline report, company report or official report of Astex Pharmaceuticals. DMVZXIA RU https://astx.com/research-development/clinical-pipeline/ DM9EM5G DI DM9EM5G DM9EM5G DN ASTX295 DM9EM5G MI TT08GJW DM9EM5G MN Ubiquitin-protein ligase E3 Mdm2 (MDM2) DM9EM5G MT DTT DM9EM5G MA Antagonist DM9EM5G RN Clinical pipeline report, company report or official report of Astex Pharmaceuticals. DM9EM5G RU https://astx.com/research-development/clinical-pipeline/astx295-oral-murine-double-minute-2-mdm2-antagonist-solid-tumors/ DMSOQ6E DI DMSOQ6E DMSOQ6E DN AT-342 DMSOQ6E MI TT34ZAF DMSOQ6E MN UDP-glucuronosyltransferase 1A1 (UGT1A1) DMSOQ6E MT DTT DMSOQ6E MA Replacement DMSOQ6E RN ClinicalTrials.gov (NCT03223194) Gene Transfer Clinical Study in Crigler-Najjar Syndrome (VALENS). U.S. National Institutes of Health. DMSOQ6E RU https://clinicaltrials.gov/ct2/show/NCT03223194 DM7O89Q DI DM7O89Q DM7O89Q DN AT-777 DM7O89Q MI TTMVBWH DM7O89Q MN Hepatitis C virus RNA-directed RNA polymerase (HCV NS5B) DM7O89Q MT DTT DM7O89Q MA Inhibitor DM7O89Q RN Clinical pipeline report, company report or official report of Atea Pharmaceuticals. DM7O89Q RU https://ateapharma.com/about-us/hepatitis-c/ DMB5X7Z DI DMB5X7Z DMB5X7Z DN ATG002 DMB5X7Z MI TTJSZTB DMB5X7Z MN Nicotinic acetylcholine receptor (nAChR) DMB5X7Z MT DTT DMB5X7Z MA Agonist DMB5X7Z RN Athenagen Advances Angiogenesis Drug to Clinical Testing. Athenagen. JUNE 21, 2006. DMB5X7Z RU http://www.prnewswire.com/news-releases/athenagen-advances-angiogenesis-drug-to-clinical-testing-56212977.html DM84YEC DI DM84YEC DM84YEC DN Atiprimod DM84YEC MI TTH8FZW DM84YEC MN Signal transducer and activator of transcription 3 (STAT3) DM84YEC MT DTT DM84YEC MA Inhibitor DM84YEC RN Emerging therapies for multiple myeloma. Expert Opin Emerg Drugs. 2009 Mar;14(1):99-127. DM84YEC RU https://pubmed.ncbi.nlm.nih.gov/19249983 DM75QY9 DI DM75QY9 DM75QY9 DN ATL-313 DM75QY9 MI TTM2AOE DM75QY9 MN Adenosine A2a receptor (ADORA2A) DM75QY9 MT DTT DM75QY9 MA Agonist DM75QY9 RN Effect of novel A2A adenosine receptor agonist ATL 313 on Clostridium difficile toxin A-induced murine ileal enteritis. Infect Immun. 2006 May;74(5):2606-12. DM75QY9 RU https://pubmed.ncbi.nlm.nih.gov/16622196 DMLAKPI DI DMLAKPI DMLAKPI DN AU101 DMLAKPI MI TTQ13FT DMLAKPI MN T-cell-specific surface glycoprotein CD28 (CD28) DMLAKPI MT DTT DMLAKPI MA Immunomodulator DMLAKPI RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMLAKPI RU http://phrma-docs.phrma.org/files/dmfile/MID_Immuno-Oncology-2017_Drug-List1.pdf DMPAZ3U DI DMPAZ3U DMPAZ3U DN AU105 DMPAZ3U MI TT6EO5L DMPAZ3U MN Erbb2 tyrosine kinase receptor (HER2) DMPAZ3U MT DTT DMPAZ3U MA Immunomodulator DMPAZ3U RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMPAZ3U RU http://phrma-docs.phrma.org/files/dmfile/MID_Immuno-Oncology-2017_Drug-List1.pdf DMG9OAV DI DMG9OAV DMG9OAV DN AUTO1 DMG9OAV MI TTW640A DMG9OAV MN B-lymphocyte surface antigen B4 (CD19) DMG9OAV MT DTT DMG9OAV RN Clinical pipeline report, company report or official report of Autolus Therapeutics. DMG9OAV RU https://www.autolus.com/pipeline/ DM0PWX2 DI DM0PWX2 DM0PWX2 DN AUTO2 DM0PWX2 MI TTZ3P4W DM0PWX2 MN B-cell maturation protein (TNFRSF17) DM0PWX2 MT DTT DM0PWX2 MA CAR-T-Cell-Therapy(Dual specific) DM0PWX2 RN ClinicalTrials.gov (NCT03287804) APRIL CAR T Cells (AUTO2) Targeting BCMA and TACI for the Treatment of Multiple Myeloma DM0PWX2 RU https://clinicaltrials.gov/ct2/show/NCT03287804 DM0PWX2 DI DM0PWX2 DM0PWX2 DN AUTO2 DM0PWX2 MI TTL9OD4 DM0PWX2 MN Transmembrane activator and CAML interactor (TNFRSF13B) DM0PWX2 MT DTT DM0PWX2 MA CAR-T-Cell-Therapy(Dual specific) DM0PWX2 RN ClinicalTrials.gov (NCT03287804) APRIL CAR T Cells (AUTO2) Targeting BCMA and TACI for the Treatment of Multiple Myeloma DM0PWX2 RU https://clinicaltrials.gov/ct2/show/NCT03287804 DMC5NSO DI DMC5NSO DMC5NSO DN AUTO3 DMC5NSO MI TTM6QSK DMC5NSO MN B-cell receptor CD22 (CD22) DMC5NSO MT DTT DMC5NSO MA CAR-T-Cell-Therapy(Dual specific) DMC5NSO RN ClinicalTrials.gov (NCT03289455) CD19 /22 CAR T Cells (AUTO3) for the Treatment of B Cell ALL DMC5NSO RU https://clinicaltrials.gov/ct2/show/NCT03289455 DMC5NSO DI DMC5NSO DMC5NSO DN AUTO3 DMC5NSO MI TTW640A DMC5NSO MN B-lymphocyte surface antigen B4 (CD19) DMC5NSO MT DTT DMC5NSO MA CAR-T-Cell-Therapy(Dual specific) DMC5NSO RN ClinicalTrials.gov (NCT03289455) CD19 /22 CAR T Cells (AUTO3) for the Treatment of B Cell ALL DMC5NSO RU https://clinicaltrials.gov/ct2/show/NCT03289455 DM2YTGQ DI DM2YTGQ DM2YTGQ DN Autologous Anti-CD19CAR-4-1BB-CD3zeta-EGFRt-expressing T Lymphocytes DM2YTGQ MI TTW640A DM2YTGQ MN B-lymphocyte surface antigen B4 (CD19) DM2YTGQ MT DTT DM2YTGQ MA CAR-T-Cell-Therapy DM2YTGQ RN ClinicalTrials.gov (NCT01865617) Laboratory Treated T Cells in Treating Patients With Relapsed or Refractory Chronic Lymphocytic Leukemia, Non-Hodgkin Lymphoma, or Acute Lymphoblastic Leukemia DM2YTGQ RU https://clinicaltrials.gov/ct2/show/NCT01865617 DMLOGI4 DI DMLOGI4 DMLOGI4 DN Autologous CD19-targeting CAR T cells DMLOGI4 MI TTW640A DMLOGI4 MN B-lymphocyte surface antigen B4 (CD19) DMLOGI4 MT DTT DMLOGI4 MA CAR-T-Cell-Therapy DMLOGI4 RN ClinicalTrials.gov (NCT02963038) CAR T Cells for Refractory B Cell Malignancy DMLOGI4 RU https://clinicaltrials.gov/ct2/show/NCT02963038 DMRS58M DI DMRS58M DMRS58M DN Avrina DMRS58M MI TTSXVID DMRS58M MN Nuclear factor NF-kappa-B (NFKB) DMRS58M MT DTT DMRS58M MA Modulator DMRS58M RN Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41. DMRS58M RU https://www.ncbi.nlm.nih.gov/pubmed/15950434 DMC1XHK DI DMC1XHK DMC1XHK DN AVR-RD-01 DMC1XHK MI TTIS03D DMC1XHK MN Alpha-galactosidase A (GLA) DMC1XHK MT DTT DMC1XHK RN Clinical pipeline report, company report or official report of Avrobio. DMC1XHK RU https://www.avrobio.com/our-pipeline/ DMOPVIQ DI DMOPVIQ DMOPVIQ DN AVX701 DMOPVIQ MI TTY6DTE DMOPVIQ MN Carcinoembryonic antigen CEA (CD66e) DMOPVIQ MT DTT DMOPVIQ MA Modulator DMOPVIQ RN Viral vector-based therapeutic cancer vaccines. Cancer J. 2011 Sep-Oct;17(5):359-71. DMOPVIQ RU https://pubmed.ncbi.nlm.nih.gov/21952287 DM7O29W DI DM7O29W DM7O29W DN AVX901 DM7O29W MI TT6EO5L DM7O29W MN Erbb2 tyrosine kinase receptor (HER2) DM7O29W MT DTT DM7O29W MA Inhibitor DM7O29W RN ClinicalTrials.gov (NCT01526473) A Phase I Study To Evaluate The Antitumor Activity And Safety Of AVX901. U.S. National Institutes of Health. DM7O29W RU https://clinicaltrials.gov/ct2/show/NCT01526473 DMWLZI6 DI DMWLZI6 DMWLZI6 DN AZD0466 DMWLZI6 MI TTJGNVC DMWLZI6 MN Apoptosis regulator Bcl-2 (BCL-2) DMWLZI6 MT DTT DMWLZI6 MA Inhibitor DMWLZI6 RN Design and optimisation of dendrimer-conjugated Bcl-2/x L inhibitor, AZD0466, with improved therapeutic index for cancer therapy. Commun Biol. 2021 Jan 25;4(1):112. DMWLZI6 RU https://pubmed.ncbi.nlm.nih.gov/33495510 DMWLZI6 DI DMWLZI6 DMWLZI6 DN AZD0466 DMWLZI6 MI TTU1E82 DMWLZI6 MN Apoptosis regulator Bcl-xL (BCL-xL) DMWLZI6 MT DTT DMWLZI6 MA Inhibitor DMWLZI6 RN Design and optimisation of dendrimer-conjugated Bcl-2/x L inhibitor, AZD0466, with improved therapeutic index for cancer therapy. Commun Biol. 2021 Jan 25;4(1):112. DMWLZI6 RU https://pubmed.ncbi.nlm.nih.gov/33495510 DMT2FAP DI DMT2FAP DMT2FAP DN AZD-2836 DMT2FAP MI TTCJ2X8 DMT2FAP MN Hepatitis C virus Non-structural 5A (HCV NS5A) DMT2FAP MT DTT DMT2FAP MA Modulator DMT2FAP RN TARGETING THE NS5A PROTEIN OF HCV: AN EMERGING OPTION. Drugs Future. 2011 September; 36(9): 691-711. DMT2FAP RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3558953/ DMD9Y5T DI DMD9Y5T DMD9Y5T DN AZD7648 DMD9Y5T MI TTK3PY9 DMD9Y5T MN DNA-dependent protein kinase catalytic (PRKDC) DMD9Y5T MT DTT DMD9Y5T MA Inhibitor DMD9Y5T RN AZD7648 is a potent and selective DNA-PK inhibitor that enhances radiation, chemotherapy and olaparib activity. Nat Commun. 2019 Nov 7;10(1):5065. DMD9Y5T RU https://pubmed.ncbi.nlm.nih.gov/31699977 DMPFGL8 DI DMPFGL8 DMPFGL8 DN BAL-101553 DMPFGL8 MI TTML2WA DMPFGL8 MN Tubulin (TUB) DMPFGL8 MT DTT DMPFGL8 MA Inhibitor DMPFGL8 RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMPFGL8 RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DMPFGL8 DI DMPFGL8 DMPFGL8 DN BAL-101553 DMPFGL8 MI TTYFKSZ DMPFGL8 MN Tubulin beta (TUBB) DMPFGL8 MT DTT DMPFGL8 MA Inhibitor DMPFGL8 RN Initial testing (stage 1) of BAL101553, a novel tubulin binding agent, by the pediatric preclinical testing program. Pediatr Blood Cancer. 2015 Jun;62(6):1106-9. DMPFGL8 RU https://pubmed.ncbi.nlm.nih.gov/25407467 DMFA4CK DI DMFA4CK DMFA4CK DN BAY 1902607 DMFA4CK MI TT2THBD DMFA4CK MN P2X purinoceptor 3 (P2RX3) DMFA4CK MT DTT DMFA4CK MA Antagonist DMFA4CK RN Antibodies and venom peptides: new modalities for ion channels. Nat Rev Drug Discov. 2019 May;18(5):339-357. DMFA4CK RU https://pubmed.ncbi.nlm.nih.gov/30728472 DMH70A9 DI DMH70A9 DMH70A9 DN BCMA CAR T cells DMH70A9 MI TTZ3P4W DMH70A9 MN B-cell maturation protein (TNFRSF17) DMH70A9 MT DTT DMH70A9 MA CAR-T-Cell-Therapy DMH70A9 RN ClinicalTrials.gov (NCT03271632) Multi-CAR T Cell Therapy in the Treatment of Multiple Myeloma DMH70A9 RU https://clinicaltrials.gov/ct2/show/NCT03271632 DM1DHPO DI DM1DHPO DM1DHPO DN BCMA CAR-T DM1DHPO MI TTZ3P4W DM1DHPO MN B-cell maturation protein (TNFRSF17) DM1DHPO MT DTT DM1DHPO MA CAR-T-Cell-Therapy DM1DHPO RN ClinicalTrials.gov (NCT03322735) Study of BCMA CAR-T in Multiple Myeloma DM1DHPO RU https://clinicaltrials.gov/ct2/show/NCT03322735 DMZK7IT DI DMZK7IT DMZK7IT DN BCT-100 DMZK7IT MI TTSANDR DMZK7IT MN Arginase (ARG) DMZK7IT MT DTT DMZK7IT MA Modulator DMZK7IT RN Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41. DMZK7IT RU https://www.ncbi.nlm.nih.gov/pubmed/15950434 DMJ5MPG DI DMJ5MPG DMJ5MPG DN BDC-1001 DMJ5MPG MI TTY6DTE DMJ5MPG MN Carcinoembryonic antigen CEA (CD66e) DMJ5MPG MT DTT DMJ5MPG RN Clinical pipeline report, company report or official report of Bolt Biotherapeutics. DMJ5MPG RU https://www.boltbio.com/pipeline/ DMODTX5 DI DMODTX5 DMODTX5 DN BDTX-189 DMODTX5 MI TTGKNB4 DMODTX5 MN Epidermal growth factor receptor (EGFR) DMODTX5 MT DTT DMODTX5 MA Inhibitor DMODTX5 RN Clinical pipeline report, company report or official report of Black Diamond Therapeutics. DMODTX5 RU https://www.blackdiamondtherapeutics.com/pipeline/bdtx-189/ DMODTX5 DI DMODTX5 DMODTX5 DN BDTX-189 DMODTX5 MI TT6EO5L DMODTX5 MN Erbb2 tyrosine kinase receptor (HER2) DMODTX5 MT DTT DMODTX5 MA Inhibitor DMODTX5 RN Clinical pipeline report, company report or official report of Black Diamond Therapeutics. DMODTX5 RU https://www.blackdiamondtherapeutics.com/pipeline/bdtx-189/ DMXVRI0 DI DMXVRI0 DMXVRI0 DN Beclanorsen DMXVRI0 MI TTFOUV4 DMXVRI0 MN BCL-2 messenger RNA (BCL2 mRNA) DMXVRI0 MT DTT DMXVRI0 RN Combination of novel imidazopyridazine mps-1 kinase inhibitors and bcl-2 family protein inhibitors. ACS Med Chem Lett. 2014 Jul 30;6(1):7-8. DMXVRI0 RU https://pubmed.ncbi.nlm.nih.gov/25589916 DMVYTG7 DI DMVYTG7 DMVYTG7 DN BGB-283 DMVYTG7 MI TTWCGQT DMVYTG7 MN Serine/threonine-protein kinase B-raf (BRAF) DMVYTG7 MT DTT DMVYTG7 MA Inhibitor DMVYTG7 RN BGB-283, a Novel RAF Kinase and EGFR Inhibitor, Displays Potent Antitumor Activity in BRAF-Mutated Colorectal Cancers. Mol Cancer Ther. 2015 Oct;14(10):2187-97. DMVYTG7 RU https://pubmed.ncbi.nlm.nih.gov/26208524 DM5VG6S DI DM5VG6S DM5VG6S DN BGB-A333 DM5VG6S MI TT8ZLTI DM5VG6S MN Programmed cell death 1 ligand 1 (PD-L1) DM5VG6S MT DTT DM5VG6S RN Clinical pipeline report, company report or official report of BeiGene. DM5VG6S RU https://www.beigene.com/science-and-product-portfolio/pipeline DMI42Q0 DI DMI42Q0 DMI42Q0 DN BGB-A425 DMI42Q0 MI TT1RWL7 DMI42Q0 MN Hepatitis A virus cellular receptor 2 (TIM3) DMI42Q0 MT DTT DMI42Q0 RN Clinical pipeline report, company report or official report of BeiGene. DMI42Q0 RU https://www.beigene.com/science-and-product-portfolio/pipeline DMXKDUL DI DMXKDUL DMXKDUL DN BGT226 DMXKDUL MI TTHBTOP DMXKDUL MN PI3-kinase gamma (PIK3CG) DMXKDUL MT DTT DMXKDUL MA Modulator DMXKDUL RN Simultaneous targeting of PI3K and mTOR with NVP-BGT226 is highly effective in multiple myeloma. Anticancer Drugs. 2012 Jan;23(1):131-8. DMXKDUL RU https://pubmed.ncbi.nlm.nih.gov/21959532 DMXKDUL DI DMXKDUL DMXKDUL DN BGT226 DMXKDUL MI TTCJG29 DMXKDUL MN Serine/threonine-protein kinase mTOR (mTOR) DMXKDUL MT DTT DMXKDUL MA Modulator DMXKDUL RN Simultaneous targeting of PI3K and mTOR with NVP-BGT226 is highly effective in multiple myeloma. Anticancer Drugs. 2012 Jan;23(1):131-8. DMXKDUL RU https://pubmed.ncbi.nlm.nih.gov/21959532 DMTOMWB DI DMTOMWB DMTOMWB DN BI 1206 DMTOMWB MI TT5RWKQ DMTOMWB MN Immunoglobulin gamma Fc receptor IIB (FCGR2B) DMTOMWB MT DTT DMTOMWB RN Clinical pipeline report, company report or official report of BioInvent. DMTOMWB RU https://www.bioinvent.com/pipeline/bi-1206-in-solid-tumors/ DMR8EPF DI DMR8EPF DMR8EPF DN BIIB-087 DMR8EPF MI TTT2CZY DMR8EPF MN Retinoschisin (RS1) DMR8EPF MT DTT DMR8EPF RN ClinicalTrials.gov (NCT02416622) Safety and Efficacy of rAAV-hRS1 in Patients With X-linked Retinoschisis (XLRS). U.S. National Institutes of Health. DMR8EPF RU https://clinicaltrials.gov/ct2/show/NCT02416622 DMV1EA9 DI DMV1EA9 DMV1EA9 DN BIL010t DMV1EA9 MI TT473XN DMV1EA9 MN P2X purinoceptor 7 (P2RX7) DMV1EA9 MT DTT DMV1EA9 RN Antibodies and venom peptides: new modalities for ion channels. Nat Rev Drug Discov. 2019 May;18(5):339-357. DMV1EA9 RU https://pubmed.ncbi.nlm.nih.gov/30728472 DMZEA9X DI DMZEA9X DMZEA9X DN BIW-8962 DMZEA9X MI TTGOFW6 DMZEA9X MN Ganglioside GM2 activator (GM2A) DMZEA9X MT DTT DMZEA9X RN Genetically engineered humanized anti-ganglioside GM2 antibody against multiple organ metastasis produced by GM2-expressing small-cell lung cancer cells. Cancer Sci. 2011 Dec;102(12):2157-63. DMZEA9X RU https://pubmed.ncbi.nlm.nih.gov/21895875 DMFKA4G DI DMFKA4G DMFKA4G DN BLZ-100 DMFKA4G MI TTCYAXN DMFKA4G MN Chloride channel unspecific (ClC) DMFKA4G MT DTT DMFKA4G MA Inhibitor DMFKA4G RN Antibodies and venom peptides: new modalities for ion channels. Nat Rev Drug Discov. 2019 May;18(5):339-357. DMFKA4G RU https://pubmed.ncbi.nlm.nih.gov/30728472 DMFKA4G DI DMFKA4G DMFKA4G DN BLZ-100 DMFKA4G MI TT1GHVO DMFKA4G MN Matrix metalloproteinase (MMP) DMFKA4G MT DTT DMFKA4G MA Inhibitor DMFKA4G RN Antibodies and venom peptides: new modalities for ion channels. Nat Rev Drug Discov. 2019 May;18(5):339-357. DMFKA4G RU https://pubmed.ncbi.nlm.nih.gov/30728472 DMFKA4G DI DMFKA4G DMFKA4G DN BLZ-100 DMFKA4G MI TT6X50U DMFKA4G MN Matrix metalloproteinase-9 (MMP-9) DMFKA4G MT DTT DMFKA4G MA Inhibitor DMFKA4G RN Antibodies and venom peptides: new modalities for ion channels. Nat Rev Drug Discov. 2019 May;18(5):339-357. DMFKA4G RU https://pubmed.ncbi.nlm.nih.gov/30728472 DMDQO0S DI DMDQO0S DMDQO0S DN BMS-753493 DMDQO0S MI TTVC37M DMDQO0S MN Folate receptor alpha (FOLR1) DMDQO0S MT DTT DMDQO0S MA Modulator DMDQO0S RN A phase I pharmacokinetic and safety analysis of epothilone folate (BMS-753493), a folate receptor targeted chemotherapeutic agent in humans with advanced solid tumors. Invest New Drugs. 2015 Apr;33(2):321-31. DMDQO0S RU https://pubmed.ncbi.nlm.nih.gov/25380635 DMGM7QD DI DMGM7QD DMGM7QD DN BMS-777607 DMGM7QD MI TTNDSF4 DMGM7QD MN Proto-oncogene c-Met (MET) DMGM7QD MT DTT DMGM7QD MA Inhibitor DMGM7QD RN Discovery of N-(4-(2-amino-3-chloropyridin-4-yloxy)-3-fluorophenyl)-4-ethoxy-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide (BMS-777607... J Med Chem. 2009 Mar 12;52(5):1251-4. DMGM7QD RU https://pubmed.ncbi.nlm.nih.gov/19260711 DM5HUY8 DI DM5HUY8 DM5HUY8 DN BMS-863233 DM5HUY8 MI TTSMTDI DM5HUY8 MN CDC7-related kinase (CDC7) DM5HUY8 MT DTT DM5HUY8 MA Modulator DM5HUY8 RN Discovery of XL413, a potent and selective CDC7 inhibitor. Bioorg Med Chem Lett. 2012 Jun 1;22(11):3727-31. DM5HUY8 RU https://pubmed.ncbi.nlm.nih.gov/22560567 DMDCHM7 DI DMDCHM7 DMDCHM7 DN BMS-986016 DMDCHM7 MI TTNVXAW DMDCHM7 MN Lymphocyte activation gene 3 protein (LAG3) DMDCHM7 MT DTT DMDCHM7 MA Modulator DMDCHM7 RN Nivolumab in NSCLC: latest evidence and clinical potential. Ther Adv Med Oncol. 2015 March; 7(2): 85-96. DMDCHM7 RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4346216/ DM6LDI4 DI DM6LDI4 DM6LDI4 DN BMS-986158 DM6LDI4 MI TTE4BSY DM6LDI4 MN Bromodomain and extraterminal domain protein (BET) DM6LDI4 MT DTT DM6LDI4 MA Inhibitor DM6LDI4 RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DM6LDI4 RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DMM10J4 DI DMM10J4 DMM10J4 DN BMS-986288 DMM10J4 MI TTI2S1D DMM10J4 MN Cytotoxic T-lymphocyte protein 4 (CTLA-4) DMM10J4 MT DTT DMM10J4 MA Inhibitor DMM10J4 RN Clinical pipeline report, company report or official report of CytomX Therapeutics. DMM10J4 RU https://cytomx.com/pipeline/ DMTEY1L DI DMTEY1L DMTEY1L DN BMS-986315 DMTEY1L MI TTC4IMS DMTEY1L MN NKG2-A/B-activating NK receptor (NKG2A) DMTEY1L MT DTT DMTEY1L MA Inhibitor DMTEY1L RN ClinicalTrials.gov (NCT04349267) Study of BMS-986315 Alone and in Combination With Nivolumab or Cetuximab in Participants With Advanced Solid Tumors. U.S. National Institutes of Health. DMTEY1L RU https://clinicaltrials.gov/ct2/show/NCT04349267 DMA9MP5 DI DMA9MP5 DMA9MP5 DN BN-2629 DMA9MP5 MI DTI7UX6 DMA9MP5 MN Breast cancer resistance protein (ABCG2) DMA9MP5 MT DTP DMA9MP5 MA Substrate DMA9MP5 RN Optimization of the antitumor activity of sequence-specific pyrrolobenzodiazepine derivatives based on their affinity for ABC transporters. AAPS J. 2010 Dec;12(4):617-27. DMA9MP5 RU https://doi.org/10.1208/s12248-010-9225-x DMA9MP5 DI DMA9MP5 DMA9MP5 DN BN-2629 DMA9MP5 MI TTUTN1I DMA9MP5 MN Human Deoxyribonucleic acid (hDNA) DMA9MP5 MT DTT DMA9MP5 MA Binder DMA9MP5 RN Single-Nucleotide Polymorphisms in Rv2629 Are Specific for Mycobacterium tuberculosis Genotypes Beijing and Ghana but Not Associated with Rifampin Resistance . J Clin Microbiol. 2009 January; 47(1): 223-226. DMA9MP5 RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2620844/ DMGF2PU DI DMGF2PU DMGF2PU DN BNT411 DMGF2PU MI TTRJ1K4 DMGF2PU MN Toll-like receptor 7 (TLR7) DMGF2PU MT DTT DMGF2PU MA Agonist DMGF2PU RN Clinical pipeline report, company report or official report of BioNTech. DMGF2PU RU https://biontech.de/science/pipeline DMIMA4V DI DMIMA4V DMIMA4V DN BPX-501 DMIMA4V MI TTXQYT6 DMIMA4V MN T-cells (T-cells) DMIMA4V MT DTT DMIMA4V MA Immunomodulator DMIMA4V RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMIMA4V RU http://phrma-docs.phrma.org/files/dmfile/MID_Immuno-Oncology-2017_Drug-List1.pdf DMV9QGW DI DMV9QGW DMV9QGW DN BPX-601 DMV9QGW MI TT9T4AV DMV9QGW MN Prostate stem cell antigen (PSCA) DMV9QGW MT DTT DMV9QGW MA CAR-T-Cell-Therapy DMV9QGW RN ClinicalTrials.gov (NCT02744287) Use of Ligand-Inducible Autologous T Cells Engineered to Target PSCA on Tumor Cells in Selected Advanced Solid Tumors DMV9QGW RU https://clinicaltrials.gov/ct2/show/NCT02744287 DMCEGP2 DI DMCEGP2 DMCEGP2 DN BrevaRex DMCEGP2 MI TTBHFYQ DMCEGP2 MN Mucin-1 (MUC1) DMCEGP2 MT DTT DMCEGP2 RN Phase I trial of a murine antibody to MUC1 in patients with metastatic cancer: evidence for the activation of humoral and cellular antitumor immunity. Ann Oncol. 2004 Dec;15(12):1825-33. DMCEGP2 RU https://pubmed.ncbi.nlm.nih.gov/15550589 DMQKXSW DI DMQKXSW DMQKXSW DN BRN-3122594 DMQKXSW MI DE4LYSA DMQKXSW MN Cytochrome P450 3A4 (CYP3A4) DMQKXSW MT DME DMQKXSW MA Metabolism DMQKXSW RN Regulation of drug-metabolizing cytochrome P450 enzymes by glucocorticoids. Drug Metab Rev. 2010 Nov;42(4):621-35. DMQKXSW RU https://www.ncbi.nlm.nih.gov/pubmed/?term=20482443 DMYBKMV DI DMYBKMV DMYBKMV DN BT5528 DMYBKMV MI TTRJB2G DMYBKMV MN Ephrin type-A receptor 2 (EPHA2) DMYBKMV MT DTT DMYBKMV RN MMAE Delivery Using the Bicycle Toxin Conjugate BT5528. Mol Cancer Ther. 2020 Jul;19(7):1385-1394. DMYBKMV RU https://pubmed.ncbi.nlm.nih.gov/32398269 DM1FJW6 DI DM1FJW6 DM1FJW6 DN BT8009 DM1FJW6 MI TTPO9EG DM1FJW6 MN Nectin cell adhesion molecule 4 (NECTIN4) DM1FJW6 MT DTT DM1FJW6 RN Clinical pipeline report, company report or official report of Bicycle Therapeutics. DM1FJW6 RU https://www.bicycletherapeutics.com/wp-content/uploads/BT8009-AACR-4479-Rigby.pdf DMEWXFK DI DMEWXFK DMEWXFK DN C 82 DMEWXFK MI TTRPKQG DMEWXFK MN Beta-catenin (CTNNB1) DMEWXFK MT DTT DMEWXFK MA Inhibitor DMEWXFK RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMEWXFK RU http://phrma-docs.phrma.org/files/dmfile/medicines-in-development-drug-list-autoimmune-diseases.pdf DMEWXFK DI DMEWXFK DMEWXFK DN C 82 DMEWXFK MI TTFRCTK DMEWXFK MN CREB-binding protein (CREBBP) DMEWXFK MT DTT DMEWXFK MA Inhibitor DMEWXFK RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMEWXFK RU http://phrma-docs.phrma.org/files/dmfile/medicines-in-development-drug-list-autoimmune-diseases.pdf DMPJLS4 DI DMPJLS4 DMPJLS4 DN CAD-1883 DMPJLS4 MI TTKU9YD DMPJLS4 MN Calcium-activated potassium channel KCa2 (KCNN) DMPJLS4 MT DTT DMPJLS4 MA Activator DMPJLS4 RN Antibodies and venom peptides: new modalities for ion channels. Nat Rev Drug Discov. 2019 May;18(5):339-357. DMPJLS4 RU https://pubmed.ncbi.nlm.nih.gov/30728472 DMUZIRY DI DMUZIRY DMUZIRY DN Cal-1 DMUZIRY MI TT2CEJG DMUZIRY MN C-C chemokine receptor type 5 (CCR5) DMUZIRY MT DTT DMUZIRY MA Modulator DMUZIRY RN Preclinical safety and efficacy of an anti-HIV-1 lentiviral vector containing a short hairpin RNA to CCR5 and the C46 fusion inhibitor. Mol Ther Methods Clin Dev. 2014 Feb 12;1:11. DMUZIRY RU https://pubmed.ncbi.nlm.nih.gov/26015947 DM6ZXWY DI DM6ZXWY DM6ZXWY DN CAR.CD30 cells DM6ZXWY MI TT2GM5R DM6ZXWY MN Lymphocyte activation antigen CD30 (TNFRSF8) DM6ZXWY MT DTT DM6ZXWY MA CAR-T-Cell-Therapy DM6ZXWY RN ClinicalTrials.gov (NCT02663297) Administration of T Lymphocytes for Prevention of Relapse of Lymphomas DM6ZXWY RU https://clinicaltrials.gov/ct2/show/NCT02663297 DMOI5PB DI DMOI5PB DMOI5PB DN CARCIK-CD19 DMOI5PB MI TTW640A DMOI5PB MN B-lymphocyte surface antigen B4 (CD19) DMOI5PB MT DTT DMOI5PB MA CAR-T-Cell-Therapy DMOI5PB RN ClinicalTrials.gov (NCT03389035) Transposon-manipulated Allogeneic CARCIK-CD19 Cells in Pediatric and Adult Patients With r/r ALL Post HSCT DMOI5PB RU https://clinicaltrials.gov/ct2/show/NCT03389035 DMENIQ7 DI DMENIQ7 DMENIQ7 DN CAR-T cells targeting BCMA DMENIQ7 MI TTZ3P4W DMENIQ7 MN B-cell maturation protein (TNFRSF17) DMENIQ7 MT DTT DMENIQ7 MA CAR-T-Cell-Therapy DMENIQ7 RN ClinicalTrials.gov (NCT03312205) CAR-T Cells for Relapsed or Refractory Haematopoietic and Lymphoid Malignancies DMENIQ7 RU https://clinicaltrials.gov/ct2/show/NCT03312205 DMIM9TZ DI DMIM9TZ DMIM9TZ DN CAR-T cells targeting CD19 DMIM9TZ MI TTW640A DMIM9TZ MN B-lymphocyte surface antigen B4 (CD19) DMIM9TZ MT DTT DMIM9TZ MA CAR-T-Cell-Therapy DMIM9TZ RN ClinicalTrials.gov (NCT03312205) CAR-T Cells for Relapsed or Refractory Haematopoietic and Lymphoid Malignancies DMIM9TZ RU https://clinicaltrials.gov/ct2/show/NCT03312205 DMJVENR DI DMJVENR DMJVENR DN CAR-T cells targeting CD2 DMJVENR MI TT80ARU DMJVENR MN Ganglioside GD2 (GD2) DMJVENR MT DTT DMJVENR MA CAR-T-Cell-Therapy DMJVENR RN ClinicalTrials.gov (NCT03356795) Intervention of CAR-T Against Cervical Cancer DMJVENR RU https://clinicaltrials.gov/ct2/show/NCT03356795 DMVFHL9 DI DMVFHL9 DMVFHL9 DN CAR-T cells targeting CD22 DMVFHL9 MI TTM6QSK DMVFHL9 MN B-cell receptor CD22 (CD22) DMVFHL9 MT DTT DMVFHL9 MA CAR-T-Cell-Therapy DMVFHL9 RN ClinicalTrials.gov (NCT03312205) CAR-T Cells for Relapsed or Refractory Haematopoietic and Lymphoid Malignancies DMVFHL9 RU https://clinicaltrials.gov/ct2/show/NCT03312205 DMZHJV8 DI DMZHJV8 DMZHJV8 DN CAR-T cells targeting CD30 DMZHJV8 MI TT2GM5R DMZHJV8 MN Lymphocyte activation antigen CD30 (TNFRSF8) DMZHJV8 MT DTT DMZHJV8 MA CAR-T-Cell-Therapy DMZHJV8 RN ClinicalTrials.gov (NCT03312205) CAR-T Cells for Relapsed or Refractory Haematopoietic and Lymphoid Malignancies DMZHJV8 RU https://clinicaltrials.gov/ct2/show/NCT03312205 DM6VCPX DI DM6VCPX DM6VCPX DN CAR-T cells targeting CEA DM6VCPX MI TTY6DTE DM6VCPX MN Carcinoembryonic antigen CEA (CD66e) DM6VCPX MT DTT DM6VCPX MA CAR-T-Cell-Therapy DM6VCPX RN ClinicalTrials.gov (NCT02959151) A Study of Chimeric Antigen Receptor T Cells Combined With Interventional Therapy in Advanced Liver Malignancy DM6VCPX RU https://clinicaltrials.gov/ct2/show/NCT02959151 DMCPM92 DI DMCPM92 DMCPM92 DN CAR-T cells targeting CLL1 DMCPM92 MI TT70N8V DMCPM92 MN Myeloid inhibitory C-type lectin-like receptor (CD371) DMCPM92 MT DTT DMCPM92 MA CAR-T-Cell-Therapy DMCPM92 RN ClinicalTrials.gov (NCT03312205) CAR-T Cells for Relapsed or Refractory Haematopoietic and Lymphoid Malignancies DMCPM92 RU https://clinicaltrials.gov/ct2/show/NCT03312205 DMREQCF DI DMREQCF DMREQCF DN CAR-T Cells targeting EpCAM DMREQCF MI TTZ8WH4 DMREQCF MN Tumor-associated calcium signal transducer 1 (EPCAM) DMREQCF MT DTT DMREQCF MA CAR-T-Cell-Therapy DMREQCF RN ClinicalTrials.gov (NCT03013712) A Clinical Research of CAR T Cells Targeting EpCAM Positive Cancer DMREQCF RU https://clinicaltrials.gov/ct2/show/NCT03013712 DMN3C2I DI DMN3C2I DMN3C2I DN CAR-T cells targeting EphA2 DMN3C2I MI TTRJB2G DMN3C2I MN Ephrin type-A receptor 2 (EPHA2) DMN3C2I MT DTT DMN3C2I MA CAR-T-Cell-Therapy DMN3C2I RN ClinicalTrials.gov (NCT02575261) CAR-T Cell Immunotherapy for EphA2 Positive Malignant Glioma Patients DMN3C2I RU https://clinicaltrials.gov/ct2/show/NCT02575261 DMFCPG0 DI DMFCPG0 DMFCPG0 DN CAR-T cells targeting GD2 DMFCPG0 MI TT80ARU DMFCPG0 MN Ganglioside GD2 (GD2) DMFCPG0 MT DTT DMFCPG0 MA CAR-T-Cell-Therapy DMFCPG0 RN ClinicalTrials.gov (NCT03252171) CAR-T Cell Immunotherapy for GD2 Positive Glioma Patients DMFCPG0 RU https://clinicaltrials.gov/ct2/show/NCT03252171 DMT89K2 DI DMT89K2 DMT89K2 DN CAR-T cells targeting GD2 DMT89K2 MI TT80ARU DMT89K2 MN Ganglioside GD2 (GD2) DMT89K2 MT DTT DMT89K2 MA CAR-T-Cell-Therapy DMT89K2 RN ClinicalTrials.gov (NCT03356808) Antigen-specific T Cells Against Lung Cancer DMT89K2 RU https://clinicaltrials.gov/ct2/show/NCT03356808 DMDSKR2 DI DMDSKR2 DMDSKR2 DN CAR-T cells targeting Glypican-3 (GPC3) DMDSKR2 MI TTJTSX4 DMDSKR2 MN Glypican-3 (GPC3) DMDSKR2 MT DTT DMDSKR2 MA CAR-T-Cell-Therapy DMDSKR2 RN ClinicalTrials.gov (NCT02723942) CAR-T Cell Immunotherapy for HCC Targeting GPC3 DMDSKR2 RU https://clinicaltrials.gov/ct2/show/NCT02723942 DM6H1MQ DI DM6H1MQ DM6H1MQ DN CAR-T cells targeting GPC3 DM6H1MQ MI TTJTSX4 DM6H1MQ MN Glypican-3 (GPC3) DM6H1MQ MT DTT DM6H1MQ MA CAR-T-Cell-Therapy DM6H1MQ RN ClinicalTrials.gov (NCT02959151) A Study of Chimeric Antigen Receptor T Cells Combined With Interventional Therapy in Advanced Liver Malignancy DM6H1MQ RU https://clinicaltrials.gov/ct2/show/NCT02959151 DM1W7LV DI DM1W7LV DM1W7LV DN CAR-T cells targeting MAGE-A1 DM1W7LV MI TT63M7Q DM1W7LV MN Melanoma-associated antigen 1 (MAGEA1) DM1W7LV MT DTT DM1W7LV MA CAR-T-Cell-Therapy DM1W7LV RN ClinicalTrials.gov (NCT03356808) Antigen-specific T Cells Against Lung Cancer DM1W7LV RU https://clinicaltrials.gov/ct2/show/NCT03356808 DMUBEX4 DI DMUBEX4 DMUBEX4 DN CAR-T cells targeting MAGE-A4 DMUBEX4 MI TT9EQUY DMUBEX4 MN Melanoma-associated antigen 4 (MAGEA4) DMUBEX4 MT DTT DMUBEX4 MA CAR-T-Cell-Therapy DMUBEX4 RN ClinicalTrials.gov (NCT03356808) Antigen-specific T Cells Against Lung Cancer DMUBEX4 RU https://clinicaltrials.gov/ct2/show/NCT03356808 DMMAQJ7 DI DMMAQJ7 DMMAQJ7 DN CAR-T cells targeting Mesothelin DMMAQJ7 MI TT4RXME DMMAQJ7 MN Mesothelin (MSLN) DMMAQJ7 MT DTT DMMAQJ7 MA CAR-T-Cell-Therapy DMMAQJ7 RN ClinicalTrials.gov (NCT03356808) Antigen-specific T Cells Against Lung Cancer DMMAQJ7 RU https://clinicaltrials.gov/ct2/show/NCT03356808 DMPK35H DI DMPK35H DMPK35H DN CAR-T cells targeting mesothelin DMPK35H MI TT4RXME DMPK35H MN Mesothelin (MSLN) DMPK35H MT DTT DMPK35H MA CAR-T-Cell-Therapy DMPK35H RN ClinicalTrials.gov (NCT02959151) A Study of Chimeric Antigen Receptor T Cells Combined With Interventional Therapy in Advanced Liver Malignancy DMPK35H RU https://clinicaltrials.gov/ct2/show/NCT02959151 DM5FKU1 DI DM5FKU1 DM5FKU1 DN CAR-T cells targeting Muc1 DM5FKU1 MI TTBHFYQ DM5FKU1 MN Mucin-1 (MUC1) DM5FKU1 MT DTT DM5FKU1 MA CAR-T-Cell-Therapy DM5FKU1 RN ClinicalTrials.gov (NCT03356795) Intervention of CAR-T Against Cervical Cancer DM5FKU1 RU https://clinicaltrials.gov/ct2/show/NCT03356795 DMBPN4K DI DMBPN4K DMBPN4K DN CAR-T cells targeting MucI DMBPN4K MI TTBHFYQ DMBPN4K MN Mucin-1 (MUC1) DMBPN4K MT DTT DMBPN4K MA CAR-T-Cell-Therapy DMBPN4K RN ClinicalTrials.gov (NCT03356808) Antigen-specific T Cells Against Lung Cancer DMBPN4K RU https://clinicaltrials.gov/ct2/show/NCT03356808 DMW340V DI DMW340V DMW340V DN CAR-T cells targeting PSMA DMW340V MI TT9G4N0 DMW340V MN Glutamate carboxypeptidase II (GCPII) DMW340V MT DTT DMW340V MA CAR-T-Cell-Therapy DMW340V RN ClinicalTrials.gov (NCT03356795) Intervention of CAR-T Against Cervical Cancer DMW340V RU https://clinicaltrials.gov/ct2/show/NCT03356795 DM0MCTJ DI DM0MCTJ DM0MCTJ DN CART-123 cells DM0MCTJ MI TTENHJ0 DM0MCTJ MN Interleukin 3 receptor alpha (IL3RA) DM0MCTJ MT DTT DM0MCTJ MA CAR-T-Cell-Therapy DM0MCTJ RN ClinicalTrials.gov (NCT03556982) CART-123 FOR Relapsed/Refractory Acute Myelocytic LeukemiaAML DM0MCTJ RU https://clinicaltrials.gov/ct2/show/NCT03556982 DMUS79V DI DMUS79V DMUS79V DN CART-138 cells DMUS79V MI TTYDSVG DMUS79V MN Syndecan-1 (SDC1) DMUS79V MT DTT DMUS79V MA CAR-T-Cell-Therapy DMUS79V RN ClinicalTrials.gov (NCT01886976) Treatment of Chemotherapy Refractory Multiple Myeloma by CART-138 DMUS79V RU https://clinicaltrials.gov/ct2/show/NCT01886976 DMB4HEW DI DMB4HEW DMB4HEW DN CART-138 cells DMB4HEW MI TTYDSVG DMB4HEW MN Syndecan-1 (SDC1) DMB4HEW MT DTT DMB4HEW MA CAR-T-Cell-Therapy DMB4HEW RN ClinicalTrials.gov (NCT03196414) Study of CART-138/BCMA Therapy for R/R Multiple Myeloma DMB4HEW RU https://clinicaltrials.gov/ct2/show/NCT03196414 DMWYT4K DI DMWYT4K DMWYT4K DN CART-19 cells DMWYT4K MI TTW640A DMWYT4K MN B-lymphocyte surface antigen B4 (CD19) DMWYT4K MT DTT DMWYT4K MA CAR-T-Cell-Therapy DMWYT4K RN ClinicalTrials.gov (NCT03544021) CART-19 FOR Relapsed/Refractory Acute Lymphoblastic Leukemia ALL DMWYT4K RU https://clinicaltrials.gov/ct2/show/NCT03544021 DMX0R1E DI DMX0R1E DMX0R1E DN CART-19/22 DMX0R1E MI TTM6QSK DMX0R1E MN B-cell receptor CD22 (CD22) DMX0R1E MT DTT DMX0R1E MA CAR-T-Cell-Therapy(Dual specific) DMX0R1E RN ClinicalTrials.gov (NCT03614858) CD19/CD22-targeted Chimeric Antigen Receptor Engineered T Cell (CART) in B-Cell Acute Lymphoblastic Leukemia. DMX0R1E RU https://clinicaltrials.gov/ct2/show/NCT03614858 DMX0R1E DI DMX0R1E DMX0R1E DN CART-19/22 DMX0R1E MI TTW640A DMX0R1E MN B-lymphocyte surface antigen B4 (CD19) DMX0R1E MT DTT DMX0R1E MA CAR-T-Cell-Therapy(Dual specific) DMX0R1E RN ClinicalTrials.gov (NCT03614858) CD19/CD22-targeted Chimeric Antigen Receptor Engineered T Cell (CART) in B-Cell Acute Lymphoblastic Leukemia. DMX0R1E RU https://clinicaltrials.gov/ct2/show/NCT03614858 DMVW1GY DI DMVW1GY DMVW1GY DN CART-19/BCMA DMVW1GY MI TTZ3P4W DMVW1GY MN B-cell maturation protein (TNFRSF17) DMVW1GY MT DTT DMVW1GY MA CAR-T-Cell-Therapy(Dual specific) DMVW1GY RN ClinicalTrials.gov (NCT03455972) Study of T Cells Targeting CD19/BCMA (CART-19/BCMA) for High Risk Multiple Myeloma Followed With Auto-HSCT DMVW1GY RU https://clinicaltrials.gov/ct2/show/NCT03455972 DMVW1GY DI DMVW1GY DMVW1GY DN CART-19/BCMA DMVW1GY MI TTW640A DMVW1GY MN B-lymphocyte surface antigen B4 (CD19) DMVW1GY MT DTT DMVW1GY MA CAR-T-Cell-Therapy(Dual specific) DMVW1GY RN ClinicalTrials.gov (NCT03455972) Study of T Cells Targeting CD19/BCMA (CART-19/BCMA) for High Risk Multiple Myeloma Followed With Auto-HSCT DMVW1GY RU https://clinicaltrials.gov/ct2/show/NCT03455972 DMKGU5F DI DMKGU5F DMKGU5F DN CART20 DMKGU5F MI TTUE541 DMKGU5F MN Leukocyte surface antigen Leu-16 (CD20) DMKGU5F MT DTT DMKGU5F MA CAR-T-Cell-Therapy DMKGU5F RN ClinicalTrials.gov (NCT02965157) Pilot Study of Anti-CD20-CAR-engineered T Cells in Patients With Chemotherapy Resistant or Refractory CD20+ Lymphoma DMKGU5F RU https://clinicaltrials.gov/ct2/show/NCT02965157 DMLE8T9 DI DMLE8T9 DMLE8T9 DN CART30 DMLE8T9 MI TT2GM5R DMLE8T9 MN Lymphocyte activation antigen CD30 (TNFRSF8) DMLE8T9 MT DTT DMLE8T9 MA CAR-T-Cell-Therapy DMLE8T9 RN ClinicalTrials.gov (NCT02259556) CD30-directed Chimeric Antigen Receptor T (CART30) Therapy in Relapsed and Refractory CD30 Positive Lymphomas DMLE8T9 RU https://clinicaltrials.gov/ct2/show/NCT02259556 DM81JIT DI DM81JIT DM81JIT DN CART33 cells DM81JIT MI TTJVYO3 DM81JIT MN Myeloid cell surface antigen CD33 (CD33) DM81JIT MT DTT DM81JIT MA CAR-T-Cell-Therapy DM81JIT RN ClinicalTrials.gov (NCT01864902) Treatment of Relapsed and/or Chemotherapy Refractory CD33 Positive Acute Myeloid Leukemia by CART-33 DM81JIT RU https://clinicaltrials.gov/ct2/show/NCT01864902 DMWOYNT DI DMWOYNT DMWOYNT DN CART-BCMA cells DMWOYNT MI TTZ3P4W DMWOYNT MN B-cell maturation protein (TNFRSF17) DMWOYNT MT DTT DMWOYNT MA CAR-T-Cell-Therapy DMWOYNT RN ClinicalTrials.gov (NCT03196414) Study of CART-138/BCMA Therapy for R/R Multiple Myeloma DMWOYNT RU https://clinicaltrials.gov/ct2/show/NCT03196414 DM3I267 DI DM3I267 DM3I267 DN CART-EGFR DM3I267 MI TTGKNB4 DM3I267 MN Epidermal growth factor receptor (EGFR) DM3I267 MT DTT DM3I267 MA CAR-T-Cell-Therapy DM3I267 RN ClinicalTrials.gov (NCT01869166) Treatment of Chemotherapy Refractory EGFR(Epidermal Growth Factor Receptor) Positive Advanced Solid Tumors (CART-EGFR) DM3I267 RU https://clinicaltrials.gov/ct2/show/NCT01869166 DMMTDK1 DI DMMTDK1 DMMTDK1 DN CART-HER-2 DMMTDK1 MI TT6EO5L DMMTDK1 MN Erbb2 tyrosine kinase receptor (HER2) DMMTDK1 MT DTT DMMTDK1 MA CAR-T-Cell-Therapy DMMTDK1 RN ClinicalTrials.gov (NCT01935843) Treatment of Chemotherapy Refractory Human Epidermalgrowth Factor Receptor-2( HER-2) Positive Advanced Solid Tumors DMMTDK1 RU https://clinicaltrials.gov/ct2/show/NCT01935843 DMKCJ75 DI DMKCJ75 DMKCJ75 DN CBL0102 DMKCJ75 MI TTETDKQ DMKCJ75 MN Facilitates chromatin transcription complex (FACT) DMKCJ75 MT DTT DMKCJ75 MA Modulator DMKCJ75 RN Company report (Incuron) DMKCJ75 RU http://www.incuron.ru/en/news-en/item/2-incuron-announce-cbl0102-orphan-drug-status-for-hepatocellular-carcinoma DMCWVPU DI DMCWVPU DMCWVPU DN CBP-501 DMCWVPU MI TTMUG9D DMCWVPU MN MAPK-activated protein kinase 2 (MAPKAPK2) DMCWVPU MT DTT DMCWVPU MA Inhibitor DMCWVPU RN National Cancer Institute Drug Dictionary (drug id 577812). DMCWVPU RU http://www.cancer.gov/publications/dictionaries/cancer-drug?cdrid=577812 DMCWVPU DI DMCWVPU DMCWVPU DN CBP-501 DMCWVPU MI TT3DCYJ DMCWVPU MN Microtubule affinity regulating kinase 3 (MARK3) DMCWVPU MT DTT DMCWVPU MA Inhibitor DMCWVPU RN National Cancer Institute Drug Dictionary (drug id 577812). DMCWVPU RU http://www.cancer.gov/publications/dictionaries/cancer-drug?cdrid=577812 DMMQYL9 DI DMMQYL9 DMMQYL9 DN CC-223 DMMQYL9 MI DE5IED8 DMMQYL9 MN Cytochrome P450 2C9 (CYP2C9) DMMQYL9 MT DME DMMQYL9 MA Metabolism DMMQYL9 RN Assessment of drug-drug interaction potential and PBPK modeling of CC-223, a potent inhibitor of the mammalian target of rapamycin kinase. Xenobiotica. 2019 Jan;49(1):54-70. DMMQYL9 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=29297772 DMMQYL9 DI DMMQYL9 DMMQYL9 DN CC-223 DMMQYL9 MI DE4LYSA DMMQYL9 MN Cytochrome P450 3A4 (CYP3A4) DMMQYL9 MT DME DMMQYL9 MA Metabolism DMMQYL9 RN Assessment of drug-drug interaction potential and PBPK modeling of CC-223, a potent inhibitor of the mammalian target of rapamycin kinase. Xenobiotica. 2019 Jan;49(1):54-70. DMMQYL9 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=29297772 DMMQYL9 DI DMMQYL9 DMMQYL9 DN CC-223 DMMQYL9 MI TTCJG29 DMMQYL9 MN Serine/threonine-protein kinase mTOR (mTOR) DMMQYL9 MT DTT DMMQYL9 MA Modulator DMMQYL9 RN CC-223, a Potent and Selective Inhibitor of mTOR Kinase: In Vitro and In Vivo Characterization. Mol Cancer Ther. 2015 Jun;14(6):1295-305. DMMQYL9 RU https://pubmed.ncbi.nlm.nih.gov/25855786 DM9UZM1 DI DM9UZM1 DM9UZM1 DN CCS1477 DM9UZM1 MI TTFRCTK DM9UZM1 MN CREB-binding protein (CREBBP) DM9UZM1 MT DTT DM9UZM1 MA Inhibitor DM9UZM1 RN Targeting the p300/CBP Axis in Lethal Prostate Cancer. Cancer Discov. 2021 May;11(5):1118-1137. DM9UZM1 RU https://pubmed.ncbi.nlm.nih.gov/33431496 DM9UZM1 DI DM9UZM1 DM9UZM1 DN CCS1477 DM9UZM1 MI TTGH73N DM9UZM1 MN Histone acetyltransferase p300 (EP300) DM9UZM1 MT DTT DM9UZM1 MA Inhibitor DM9UZM1 RN Targeting the p300/CBP Axis in Lethal Prostate Cancer. Cancer Discov. 2021 May;11(5):1118-1137. DM9UZM1 RU https://pubmed.ncbi.nlm.nih.gov/33431496 DM2B1V0 DI DM2B1V0 DM2B1V0 DN CCT301-38 (targeting ROR2) DM2B1V0 MI TTUDPCI DM2B1V0 MN Neurotrophic tyrosine kinase ROR2 (ROR2) DM2B1V0 MT DTT DM2B1V0 MA CAR-T-Cell-Therapy DM2B1V0 RN ClinicalTrials.gov (NCT03393936) Safety and Efficacy of CCT301 CAR-T in Adult Subjects With Recurrent or Refractory Stage IV Renal Cell Carcinoma DM2B1V0 RU https://clinicaltrials.gov/ct2/show/NCT03393936 DM0F9CD DI DM0F9CD DM0F9CD DN CCT301-59 (targeting ROR2) DM0F9CD MI TTUDPCI DM0F9CD MN Neurotrophic tyrosine kinase ROR2 (ROR2) DM0F9CD MT DTT DM0F9CD MA CAR-T-Cell-Therapy DM0F9CD RN ClinicalTrials.gov (NCT03393936) Safety and Efficacy of CCT301 CAR-T in Adult Subjects With Recurrent or Refractory Stage IV Renal Cell Carcinoma DM0F9CD RU https://clinicaltrials.gov/ct2/show/NCT03393936 DMHOWU5 DI DMHOWU5 DMHOWU5 DN CD123-specific gene-engineered T cells DMHOWU5 MI TTENHJ0 DMHOWU5 MN Interleukin 3 receptor alpha (IL3RA) DMHOWU5 MT DTT DMHOWU5 MA CAR-T-Cell-Therapy DMHOWU5 RN ClinicalTrials.gov (NCT03222674) Multi-CAR T Cell Therapy for Acute Myeloid Leukemia DMHOWU5 RU https://clinicaltrials.gov/ct2/show/NCT03222674 DMHMC19 DI DMHMC19 DMHMC19 DN CD137 CAR-T Cell DMHMC19 MI TTPW9LJ DMHMC19 MN Co-stimulatory molecule 4-1BB (CD137) DMHMC19 MT DTT DMHMC19 MA CAR-T-Cell-Therapy DMHMC19 RN ClinicalTrials.gov (NCT02965092) CD19 Chimeric Antigen Receptor (CAR)-Modified T Cell Therapy in Treating Patients With B-cell Malignancies DMHMC19 RU https://clinicaltrials.gov/ct2/show/NCT02965092 DMCSGNU DI DMCSGNU DMCSGNU DN CD138 CAR T cells DMCSGNU MI TTYDSVG DMCSGNU MN Syndecan-1 (SDC1) DMCSGNU MT DTT DMCSGNU MA CAR-T-Cell-Therapy DMCSGNU RN ClinicalTrials.gov (NCT03271632) Multi-CAR T Cell Therapy in the Treatment of Multiple Myeloma DMCSGNU RU https://clinicaltrials.gov/ct2/show/NCT03271632 DMRJ3ND DI DMRJ3ND DMRJ3ND DN CD19 and CD20 CAR-T Cells DMRJ3ND MI TTW640A DMRJ3ND MN B-lymphocyte surface antigen B4 (CD19) DMRJ3ND MT DTT DMRJ3ND MA CAR-T-Cell-Therapy(Dual specific) DMRJ3ND RN ClinicalTrials.gov (NCT03398967) A Feasibility and Safety Study of Universal Dual Specificity CD19 and CD20 or CD22 CAR-T Cell Immunotherapy for Relapsed or Refractory Leukemia and Lymphoma DMRJ3ND RU https://clinicaltrials.gov/ct2/show/NCT03398967 DMRJ3ND DI DMRJ3ND DMRJ3ND DN CD19 and CD20 CAR-T Cells DMRJ3ND MI TTUE541 DMRJ3ND MN Leukocyte surface antigen Leu-16 (CD20) DMRJ3ND MT DTT DMRJ3ND MA CAR-T-Cell-Therapy(Dual specific) DMRJ3ND RN ClinicalTrials.gov (NCT03398967) A Feasibility and Safety Study of Universal Dual Specificity CD19 and CD20 or CD22 CAR-T Cell Immunotherapy for Relapsed or Refractory Leukemia and Lymphoma DMRJ3ND RU https://clinicaltrials.gov/ct2/show/NCT03398967 DMQB7SZ DI DMQB7SZ DMQB7SZ DN CD19 and CD22 CAR-T Cells DMQB7SZ MI TTM6QSK DMQB7SZ MN B-cell receptor CD22 (CD22) DMQB7SZ MT DTT DMQB7SZ MA CAR-T-Cell-Therapy(Dual specific) DMQB7SZ RN ClinicalTrials.gov (NCT03398967) A Feasibility and Safety Study of Universal Dual Specificity CD19 and CD20 or CD22 CAR-T Cell Immunotherapy for Relapsed or Refractory Leukemia and Lymphoma DMQB7SZ RU https://clinicaltrials.gov/ct2/show/NCT03398967 DM581CS DI DM581CS DM581CS DN CD19 and CD22 CAR-T Cells DM581CS MI TTM6QSK DM581CS MN B-cell receptor CD22 (CD22) DM581CS MT DTT DM581CS MA CAR-T-Cell-Therapy(Dual specific) DM581CS RN ClinicalTrials.gov (NCT03468153) Dual Specificity CD19 and CD22 CAR-T Cell Immunotherapy for CD19+CD22+ Relapsed and Refractory Lymphoma DM581CS RU https://clinicaltrials.gov/ct2/show/NCT03468153 DMQB7SZ DI DMQB7SZ DMQB7SZ DN CD19 and CD22 CAR-T Cells DMQB7SZ MI TTW640A DMQB7SZ MN B-lymphocyte surface antigen B4 (CD19) DMQB7SZ MT DTT DMQB7SZ MA CAR-T-Cell-Therapy(Dual specific) DMQB7SZ RN ClinicalTrials.gov (NCT03398967) A Feasibility and Safety Study of Universal Dual Specificity CD19 and CD20 or CD22 CAR-T Cell Immunotherapy for Relapsed or Refractory Leukemia and Lymphoma DMQB7SZ RU https://clinicaltrials.gov/ct2/show/NCT03398967 DM581CS DI DM581CS DM581CS DN CD19 and CD22 CAR-T Cells DM581CS MI TTW640A DM581CS MN B-lymphocyte surface antigen B4 (CD19) DM581CS MT DTT DM581CS MA CAR-T-Cell-Therapy(Dual specific) DM581CS RN ClinicalTrials.gov (NCT03468153) Dual Specificity CD19 and CD22 CAR-T Cell Immunotherapy for CD19+CD22+ Relapsed and Refractory Lymphoma DM581CS RU https://clinicaltrials.gov/ct2/show/NCT03468153 DMQJ6YL DI DMQJ6YL DMQJ6YL DN CD19 CAR Gene Transduced T Lymphocytes DMQJ6YL MI TTW640A DMQJ6YL MN B-lymphocyte surface antigen B4 (CD19) DMQJ6YL MT DTT DMQJ6YL MA CAR-T-Cell-Therapy DMQJ6YL RN ClinicalTrials.gov (NCT02134262) Gene Therapy for B-Cell Non-Hodgkin Lymphoma Using CD19 CAR Gene Transduced T Lymphocytes DMQJ6YL RU https://clinicaltrials.gov/ct2/show/NCT02134262 DMMHLJQ DI DMMHLJQ DMMHLJQ DN CD19 CAR T cells DMMHLJQ MI TTW640A DMMHLJQ MN B-lymphocyte surface antigen B4 (CD19) DMMHLJQ MT DTT DMMHLJQ MA CAR-T-Cell-Therapy DMMHLJQ RN ClinicalTrials.gov (NCT02772198) T-cells Expressing Anti-CD19 CAR in Pediatric and Young Adults With B-cell Malignancies DMMHLJQ RU https://clinicaltrials.gov/ct2/show/NCT02772198 DMUARWH DI DMUARWH DMUARWH DN CD19 CAR T Cells DMUARWH MI TTW640A DMUARWH MN B-lymphocyte surface antigen B4 (CD19) DMUARWH MT DTT DMUARWH MA CAR-T-Cell-Therapy DMUARWH RN ClinicalTrials.gov (NCT01475058) CD19 CAR T Cells for B Cell Malignancies After Allogeneic Transplant DMUARWH RU https://clinicaltrials.gov/ct2/show/NCT01475058 DMU348C DI DMU348C DMU348C DN CD19 CART DMU348C MI TTW640A DMU348C MN B-lymphocyte surface antigen B4 (CD19) DMU348C MT DTT DMU348C MA CAR-T-Cell-Therapy DMU348C RN ClinicalTrials.gov (NCT03146533) CD19 CART Cells for Patients With Relapse and Refractory CD19+ B-cell Lymphoma. DMU348C RU https://clinicaltrials.gov/ct2/show/NCT03146533 DM69A1W DI DM69A1W DM69A1W DN CD19 CART DM69A1W MI TTW640A DM69A1W MN B-lymphocyte surface antigen B4 (CD19) DM69A1W MT DTT DM69A1W MA CAR-T-Cell-Therapy DM69A1W RN ClinicalTrials.gov (NCT03232619) CD19-CART Treatment for ALL DM69A1W RU https://clinicaltrials.gov/ct2/show/NCT03232619 DMECGKO DI DMECGKO DMECGKO DN CD19 CAR-T Cells DMECGKO MI TTW640A DMECGKO MN B-lymphocyte surface antigen B4 (CD19) DMECGKO MT DTT DMECGKO MA CAR-T-Cell-Therapy DMECGKO RN ClinicalTrials.gov (NCT03263208) CD19 CAR-T Cells for Patients With Relapse and Refractory CD19+ B-ALL. DMECGKO RU https://clinicaltrials.gov/ct2/show/NCT03263208 DM8KESD DI DM8KESD DM8KESD DN CD19 CAR-T lymphocytes DM8KESD MI TTW640A DM8KESD MN B-lymphocyte surface antigen B4 (CD19) DM8KESD MT DTT DM8KESD MA CAR-T-Cell-Therapy DM8KESD RN ClinicalTrials.gov (NCT03467256) CD19 T-CAR for Treatment of Children and Young Adults With r/r B-ALL DM8KESD RU https://clinicaltrials.gov/ct2/show/NCT03467256 DMGDK9C DI DMGDK9C DMGDK9C DN CD19 specific CAR T cells DMGDK9C MI TTW640A DMGDK9C MN B-lymphocyte surface antigen B4 (CD19) DMGDK9C MT DTT DMGDK9C MA CAR-T-Cell-Therapy DMGDK9C RN ClinicalTrials.gov (NCT02028455) A Pediatric and Young Adult Trial of Genetically Modified T Cells Directed Against CD19 for Relapsed/Refractory CD19+ Leukemia DMGDK9C RU https://clinicaltrials.gov/ct2/show/NCT02028455 DM8RXFB DI DM8RXFB DM8RXFB DN CD19 targeted chimeric antigen receptor T cells DM8RXFB MI TTW640A DM8RXFB MN B-lymphocyte surface antigen B4 (CD19) DM8RXFB MT DTT DM8RXFB MA CAR-T-Cell-Therapy DM8RXFB RN ClinicalTrials.gov (NCT03118180) CD19 Targeted Chimeric Antigen Receptor T Cells for B Cell Lymphoma DM8RXFB RU https://clinicaltrials.gov/ct2/show/NCT03118180 DM79GPF DI DM79GPF DM79GPF DN CD19.CAR T Cells DM79GPF MI TTW640A DM79GPF MN B-lymphocyte surface antigen B4 (CD19) DM79GPF MT DTT DM79GPF MA CAR-T-Cell-Therapy DM79GPF RN ClinicalTrials.gov (NCT03676504) Treatment of Patients With Relapsed or Refractory CD19+ Lymphoid Disease With T Cells Expressing a Third-generation CAR DM79GPF RU https://clinicaltrials.gov/ct2/show/NCT03676504 DMNZ7F2 DI DMNZ7F2 DMNZ7F2 DN CD19.CAR-T cells DMNZ7F2 MI TTW640A DMNZ7F2 MN B-lymphocyte surface antigen B4 (CD19) DMNZ7F2 MT DTT DMNZ7F2 MA CAR-T-Cell-Therapy DMNZ7F2 RN ClinicalTrials.gov (NCT02652910) Memory-enriched CAR-T Cells Immunotherapy for B Cell Lymphoma DMNZ7F2 RU https://clinicaltrials.gov/ct2/show/NCT02652910 DMQE7TW DI DMQE7TW DMQE7TW DN CD19-CAR T cell DMQE7TW MI TTW640A DMQE7TW MN B-lymphocyte surface antigen B4 (CD19) DMQE7TW MT DTT DMQE7TW MA CAR-T-Cell-Therapy DMQE7TW RN ClinicalTrials.gov (NCT03373071) Anti-CD19 CAR T Cells in Pediatric Patients Affected by Relapsed/Refractory CD19+ ALL and NHL DMQE7TW RU https://clinicaltrials.gov/ct2/show/NCT03373071 DMKQRUJ DI DMKQRUJ DMKQRUJ DN CD19-directed CAR-T cells DMKQRUJ MI TTW640A DMKQRUJ MN B-lymphocyte surface antigen B4 (CD19) DMKQRUJ MT DTT DMKQRUJ MA CAR-T-Cell-Therapy DMKQRUJ RN ClinicalTrials.gov (NCT02537977) CD19-directed CAR T Cells Therapy in Relapsed/Refractory B Cell Malignancy DMKQRUJ RU https://clinicaltrials.gov/ct2/show/NCT02537977 DMI2OVA DI DMI2OVA DMI2OVA DN CD19-targeting CAR T Cells DMI2OVA MI TTW640A DMI2OVA MN B-lymphocyte surface antigen B4 (CD19) DMI2OVA MT DTT DMI2OVA MA CAR-T-Cell-Therapy DMI2OVA RN ClinicalTrials.gov (NCT02547948) CD19-targeting CAR T Cells for B Cell Lymphoma DMI2OVA RU https://clinicaltrials.gov/ct2/show/NCT02547948 DM4MBUI DI DM4MBUI DM4MBUI DN CD19-TCRz-41BB and CD22-TCRz-41BB CAR-T Cells DM4MBUI MI TTM6QSK DM4MBUI MN B-cell receptor CD22 (CD22) DM4MBUI MT DTT DM4MBUI MA CAR-T-Cell-Therapy(Dual specific) DM4MBUI RN ClinicalTrials.gov (NCT02903810) Combination Transfer of CD19-TCRz-41BB and CD22-TCRz-41BB CAR-T Cells for B-cell Hematologic Malignancy DM4MBUI RU https://clinicaltrials.gov/ct2/show/NCT02903810 DM4MBUI DI DM4MBUI DM4MBUI DN CD19-TCRz-41BB and CD22-TCRz-41BB CAR-T Cells DM4MBUI MI TTW640A DM4MBUI MN B-lymphocyte surface antigen B4 (CD19) DM4MBUI MT DTT DM4MBUI MA CAR-T-Cell-Therapy(Dual specific) DM4MBUI RN ClinicalTrials.gov (NCT02903810) Combination Transfer of CD19-TCRz-41BB and CD22-TCRz-41BB CAR-T Cells for B-cell Hematologic Malignancy DM4MBUI RU https://clinicaltrials.gov/ct2/show/NCT02903810 DMHPZ8G DI DMHPZ8G DMHPZ8G DN CD20-Specific CAR T Cells DMHPZ8G MI TTUE541 DMHPZ8G MN Leukocyte surface antigen Leu-16 (CD20) DMHPZ8G MT DTT DMHPZ8G MA CAR-T-Cell-Therapy DMHPZ8G RN ClinicalTrials.gov (NCT03277729) A Phase I/II Study to Evaluate the Safety of Cellular Immunotherapy Using Autologous T Cells Engineered to Express a CD20-Specific Chimeric Antigen Receptor for Patients With Relapsed or Refractory B Cell Non-Hodgkin Lymphomas DMHPZ8G RU https://clinicaltrials.gov/ct2/show/NCT03277729 DM40NEB DI DM40NEB DM40NEB DN CD22 CAR-T DM40NEB MI TTM6QSK DM40NEB MN B-cell receptor CD22 (CD22) DM40NEB MT DTT DM40NEB MA CAR-T-Cell-Therapy DM40NEB RN ClinicalTrials.gov (NCT02794961) CD22 Targeting CAR-T Therapy Against B Cell Hematological Malignancies DM40NEB RU https://clinicaltrials.gov/ct2/show/NCT02794961 DM61MBG DI DM61MBG DM61MBG DN CD22-Targeted CAR-T cells DM61MBG MI TTM6QSK DM61MBG MN B-cell receptor CD22 (CD22) DM61MBG MT DTT DM61MBG MA CAR-T-Cell-Therapy DM61MBG RN ClinicalTrials.gov (NCT02935153) A Clinical Research of CD22-Targeted CAR-T in B Cell Malignancies DM61MBG RU https://clinicaltrials.gov/ct2/show/NCT02935153 DMM35D2 DI DMM35D2 DMM35D2 DN CD33-specific gene-engineered T cells DMM35D2 MI TTJVYO3 DMM35D2 MN Myeloid cell surface antigen CD33 (CD33) DMM35D2 MT DTT DMM35D2 MA CAR-T-Cell-Therapy DMM35D2 RN ClinicalTrials.gov (NCT03222674) Multi-CAR T Cell Therapy for Acute Myeloid Leukemia DMM35D2 RU https://clinicaltrials.gov/ct2/show/NCT03222674 DMFZS8A DI DMFZS8A DMFZS8A DN CD38 and BCMA CAR-T Cells DMFZS8A MI TTZ3P4W DMFZS8A MN B-cell maturation protein (TNFRSF17) DMFZS8A MT DTT DMFZS8A MA CAR-T-Cell-Therapy(Dual specific) DMFZS8A RN ClinicalTrials.gov (NCT03767751) A Feasibility and Safety Study of Dual Specificity CD38 and BCMA CAR-T Cell Immunotherapy for Relapsed or Refractory Multiple Myeloma DMFZS8A RU https://clinicaltrials.gov/ct2/show/NCT03767751 DMFZS8A DI DMFZS8A DMFZS8A DN CD38 and BCMA CAR-T Cells DMFZS8A MI TTPURFN DMFZS8A MN Cyclic ADP-ribose hydrolase 1 (CD38) DMFZS8A MT DTT DMFZS8A MA CAR-T-Cell-Therapy(Dual specific) DMFZS8A RN ClinicalTrials.gov (NCT03767751) A Feasibility and Safety Study of Dual Specificity CD38 and BCMA CAR-T Cell Immunotherapy for Relapsed or Refractory Multiple Myeloma DMFZS8A RU https://clinicaltrials.gov/ct2/show/NCT03767751 DMPS3I6 DI DMPS3I6 DMPS3I6 DN CD38 CAR T cells DMPS3I6 MI TTPURFN DMPS3I6 MN Cyclic ADP-ribose hydrolase 1 (CD38) DMPS3I6 MT DTT DMPS3I6 MA CAR-T-Cell-Therapy DMPS3I6 RN ClinicalTrials.gov (NCT03271632) Multi-CAR T Cell Therapy in the Treatment of Multiple Myeloma DMPS3I6 RU https://clinicaltrials.gov/ct2/show/NCT03271632 DM0USBX DI DM0USBX DM0USBX DN CD38 CAR-T Cell DM0USBX MI TTPURFN DM0USBX MN Cyclic ADP-ribose hydrolase 1 (CD38) DM0USBX MT DTT DM0USBX MA CAR-T-Cell-Therapy DM0USBX RN ClinicalTrials.gov (NCT03754764) A Feasibility and Safety Study of CD38 CAR-T Cell Immunotherapy for Relapsed B-cell Acute Lymphoblastic Leukemia After CD19 CAR-T Adoptive Cellular Immunotherapy DM0USBX RU https://clinicaltrials.gov/ct2/show/NCT03754764 DMCH98G DI DMCH98G DMCH98G DN CD38-specific gene-engineered T cells DMCH98G MI TTPURFN DMCH98G MN Cyclic ADP-ribose hydrolase 1 (CD38) DMCH98G MT DTT DMCH98G MA CAR-T-Cell-Therapy DMCH98G RN ClinicalTrials.gov (NCT03222674) Multi-CAR T Cell Therapy for Acute Myeloid Leukemia DMCH98G RU https://clinicaltrials.gov/ct2/show/NCT03222674 DMS5OL0 DI DMS5OL0 DMS5OL0 DN CD56 CAR T cells DMS5OL0 MI TTVXPHT DMS5OL0 MN Neural cell adhesion molecule 1 (NCAM1) DMS5OL0 MT DTT DMS5OL0 MA CAR-T-Cell-Therapy DMS5OL0 RN ClinicalTrials.gov (NCT03271632) Multi-CAR T Cell Therapy in the Treatment of Multiple Myeloma DMS5OL0 RU https://clinicaltrials.gov/ct2/show/NCT03271632 DM35XCT DI DM35XCT DM35XCT DN CD56-specific gene-engineered T cells DM35XCT MI TTVXPHT DM35XCT MN Neural cell adhesion molecule 1 (NCAM1) DM35XCT MT DTT DM35XCT MA CAR-T-Cell-Therapy DM35XCT RN ClinicalTrials.gov (NCT03222674) Multi-CAR T Cell Therapy for Acute Myeloid Leukemia DM35XCT RU https://clinicaltrials.gov/ct2/show/NCT03222674 DMD1V7I DI DMD1V7I DMD1V7I DN Celgosivir DMD1V7I MI TTXWASR DMD1V7I MN Intestinal maltase-glucoamylase (MGAM) DMD1V7I MT DTT DMD1V7I MA Modulator DMD1V7I RN Celgosivir, an alpha-glucosidase I inhibitor for the potential treatment of HCV infection.Curr Opin Investig Drugs.2009 Aug;10(8):860-70. DMD1V7I RU https://www.ncbi.nlm.nih.gov/pubmed/19649930 DMAO04B DI DMAO04B DMAO04B DN CEP-32496 DMAO04B MI TT4DXQT DMAO04B MN Proto-oncogene c-Ret (RET) DMAO04B MT DTT DMAO04B MA Inhibitor DMAO04B RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMAO04B RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DMAO04B DI DMAO04B DMAO04B DN CEP-32496 DMAO04B MI TTWCGQT DMAO04B MN Serine/threonine-protein kinase B-raf (BRAF) DMAO04B MT DTT DMAO04B MA Inhibitor DMAO04B RN Clinical pipeline report, company report or official report of Ambit Biosciences. DMAO04B RU http://www.ambitbio.com/CEP32496 DMY8NUF DI DMY8NUF DMY8NUF DN CEP-9722 DMY8NUF MI TTEBCY8 DMY8NUF MN Poly [ADP-ribose] polymerase (PARP) DMY8NUF MT DTT DMY8NUF MA Modulator DMY8NUF RN Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41. DMY8NUF RU https://www.ncbi.nlm.nih.gov/pubmed/15950434 DMCR7EF DI DMCR7EF DMCR7EF DN CEQ-508 DMCR7EF MI TTRPKQG DMCR7EF MN Beta-catenin (CTNNB1) DMCR7EF MT DTT DMCR7EF RN Current Progress of siRNA/shRNA Therapeutics in Clinical Trials. Biotechnol J. 2011 September; 6(9): 1130-1146. DMCR7EF RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3388104/ DMUW6KP DI DMUW6KP DMUW6KP DN CERC-803 DMUW6KP MI DEFYE6A DMUW6KP MN L-fucose isomerase (fucI) DMUW6KP MT DME DMUW6KP MA Metabolism DMUW6KP RN nan DMUW6KP RU nan DMD3XMW DI DMD3XMW DMD3XMW DN Cethrin DMD3XMW MI TTMQO60 DMD3XMW MN Rho-associated protein kinase (ROCK) DMD3XMW MT DTT DMD3XMW MA Modulator DMD3XMW RN A phase I/IIa clinical trial of a recombinant Rho protein antagonist in acute spinal cord injury. J Neurotrauma. 2011 May;28(5):787-96. DMD3XMW RU https://pubmed.ncbi.nlm.nih.gov/21381984 DMJBQ96 DI DMJBQ96 DMJBQ96 DN Cetrelimab DMJBQ96 MI TTNBFWK DMJBQ96 MN Programmed cell death protein 1 (PD-1) DMJBQ96 MT DTT DMJBQ96 RN Monoclonal Antibodies for the Treatment of Multiple Myeloma: An Update. Int J Mol Sci. 2018 Dec 7;19(12):3924. DMJBQ96 RU https://pubmed.ncbi.nlm.nih.gov/30544512 DM2BXDU DI DM2BXDU DM2BXDU DN CFG920 DM2BXDU MI TTRA5BZ DM2BXDU MN Steroid 17-alpha-monooxygenase (S17AH) DM2BXDU MT DTT DM2BXDU MA Inhibitor DM2BXDU RN Recent progress in pharmaceutical therapies for castration-resistant prostate cancer. Int J Mol Sci. 2013 Jul 4;14(7):13958-78. DM2BXDU RU https://pubmed.ncbi.nlm.nih.gov/23880851 DMB5KRA DI DMB5KRA DMB5KRA DN CFI-402411 DMB5KRA MI TTSHWUP DMB5KRA MN MEK kinase kinase 1 (MAP4K1) DMB5KRA MT DTT DMB5KRA MA Inhibitor DMB5KRA RN Clinical pipeline report, company report or official report of Treadwell Therapeutics. DMB5KRA RU https://treadwelltx.com/pipeline/ DMPYW28 DI DMPYW28 DMPYW28 DN CG-806 DMPYW28 MI TTGM6VW DMPYW28 MN Tyrosine-protein kinase BTK (ATK) DMPYW28 MT DTT DMPYW28 MA Inhibitor DMPYW28 RN Clinical pipeline report, company report or official report of Aptose Biosciences. DMPYW28 RU https://www.aptose.com/product-pipeline/cg-806-for-b-cell DMHNFXR DI DMHNFXR DMHNFXR DN Chimeric Antigen Receptor Modified T cells Targeting CD19 DMHNFXR MI TTW640A DMHNFXR MN B-lymphocyte surface antigen B4 (CD19) DMHNFXR MT DTT DMHNFXR MA CAR-T-Cell-Therapy DMHNFXR RN ClinicalTrials.gov (NCT02349698) A Clinical Research of CAR T Cells Targeting CD19 Positive Malignant B-cell Derived Leukemia and Lymphoma DMHNFXR RU https://clinicaltrials.gov/ct2/show/NCT02349698 DMIXPNG DI DMIXPNG DMIXPNG DN CHR-3996 DMIXPNG MI TT6R7JZ DMIXPNG MN Histone deacetylase 1 (HDAC1) DMIXPNG MT DTT DMIXPNG MA Inhibitor DMIXPNG RN A phase I pharmacokinetic and pharmacodynamic study of CHR-3996, an oral class I selective histone deacetylase inhibitor in refractory solid tumors. Clin Cancer Res. 2012 May 1;18(9):2687-94. DMIXPNG RU https://pubmed.ncbi.nlm.nih.gov/22553374 DMIXPNG DI DMIXPNG DMIXPNG DN CHR-3996 DMIXPNG MI TTSHTOI DMIXPNG MN Histone deacetylase 2 (HDAC2) DMIXPNG MT DTT DMIXPNG MA Inhibitor DMIXPNG RN A phase I pharmacokinetic and pharmacodynamic study of CHR-3996, an oral class I selective histone deacetylase inhibitor in refractory solid tumors. Clin Cancer Res. 2012 May 1;18(9):2687-94. DMIXPNG RU https://pubmed.ncbi.nlm.nih.gov/22553374 DMIXPNG DI DMIXPNG DMIXPNG DN CHR-3996 DMIXPNG MI TT4YWTO DMIXPNG MN Histone deacetylase 3 (HDAC3) DMIXPNG MT DTT DMIXPNG MA Inhibitor DMIXPNG RN A phase I pharmacokinetic and pharmacodynamic study of CHR-3996, an oral class I selective histone deacetylase inhibitor in refractory solid tumors. Clin Cancer Res. 2012 May 1;18(9):2687-94. DMIXPNG RU https://pubmed.ncbi.nlm.nih.gov/22553374 DM90BUD DI DM90BUD DM90BUD DN ChronSeal DM90BUD MI TTNDSF4 DM90BUD MN Proto-oncogene c-Met (MET) DM90BUD MT DTT DM90BUD MA Inhibitor DM90BUD RN Clinical pipeline report, company report or official report of Kringle Pharma. DM90BUD RU http://www.kringle-pharma.com/en/news.html DMRSI1O DI DMRSI1O DMRSI1O DN ChronVac-C hepatitis C DNA vaccine DMRSI1O MI TTZYW5V DMRSI1O MN Hepatitis C virus Deoxyribonucleic acid (HCV DNA) DMRSI1O MT DTT DMRSI1O RN Clinical pipeline report, company report or official report of Inovio Pharmaceuticals. DMRSI1O RU http://ir.inovio.com/news/news-releases/news-releases-details/2013/Inovio-Collaborator-ChronTech-Reports-Interim-Phase-II-Clinical-Study-Results-from-ChronVac-C-Vaccine-for-Hepatitis-C-Infection/default.aspx DMTV4L7 DI DMTV4L7 DMTV4L7 DN CHS-828 DMTV4L7 MI TTD1WIG DMTV4L7 MN Nicotinamide phosphoribosyltransferase (NAMPT) DMTV4L7 MT DTT DMTV4L7 MA Inhibitor DMTV4L7 RN Anticancer agent CHS-828 inhibits cellular synthesis of NAD. Biochem Biophys Res Commun. 2008 Mar 21;367(4):799-804. DMTV4L7 RU https://pubmed.ncbi.nlm.nih.gov/18201551 DMMVWSY DI DMMVWSY DMMVWSY DN CK-101 DMMVWSY MI TTG96HZ DMMVWSY MN EGFR messenger RNA (EGFR mRNA) DMMVWSY MT DTT DMMVWSY MA Inhibitor DMMVWSY RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMMVWSY RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DML8US9 DI DML8US9 DML8US9 DN CLIC-1901 DML8US9 MI TTW640A DML8US9 MN B-lymphocyte surface antigen B4 (CD19) DML8US9 MT DTT DML8US9 MA CAR-T-Cell-Therapy DML8US9 RN ClinicalTrials.gov (NCT03765177) CLIC-1901 for the Treatment of Patients With Relapsed/Refractory CD19 Positive Hematologic Malignancies DML8US9 RU https://clinicaltrials.gov/ct2/show/NCT03765177 DMCT917 DI DMCT917 DMCT917 DN CLL1-specific gene-engineered T cells DMCT917 MI TT70N8V DMCT917 MN Myeloid inhibitory C-type lectin-like receptor (CD371) DMCT917 MT DTT DMCT917 MA CAR-T-Cell-Therapy DMCT917 RN ClinicalTrials.gov (NCT03222674) Multi-CAR T Cell Therapy for Acute Myeloid Leukemia DMCT917 RU https://clinicaltrials.gov/ct2/show/NCT03222674 DM2FSM5 DI DM2FSM5 DM2FSM5 DN CLR-1401 DM2FSM5 MI TTHBTOP DM2FSM5 MN PI3-kinase gamma (PIK3CG) DM2FSM5 MT DTT DM2FSM5 MA Inhibitor DM2FSM5 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2155). DM2FSM5 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2155 DM64FY7 DI DM64FY7 DM64FY7 DN CLR457 DM64FY7 MI TTHBTOP DM64FY7 MN PI3-kinase gamma (PIK3CG) DM64FY7 MT DTT DM64FY7 MA Modulator DM64FY7 RN Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41. DM64FY7 RU https://www.ncbi.nlm.nih.gov/pubmed/15950434 DMWZOD7 DI DMWZOD7 DMWZOD7 DN CNVN-202 DMWZOD7 MI TTJ8O14 DMWZOD7 MN Tumor suppressor candidate 2 (TUSC2) DMWZOD7 MT DTT DMWZOD7 MA Suppressor DMWZOD7 RN Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800018766) DMWZOD7 RU http://adisinsight.springer.com/drugs/800018766 DM1ZGUX DI DM1ZGUX DM1ZGUX DN CPHPC DM1ZGUX MI TTB7VAT DM1ZGUX MN Serum amyloid P-component (APCS) DM1ZGUX MT DTT DM1ZGUX MA Modulator DM1ZGUX RN Interaction of serum amyloid P component with hexanoyl bis(D-proline) (CPHPC).Acta Crystallogr D Biol Crystallogr.2014 Aug;70(Pt 8):2232-40. DM1ZGUX RU https://www.ncbi.nlm.nih.gov/pubmed/25084341 DMJEXLI DI DMJEXLI DMJEXLI DN CPI-0209 DMJEXLI MI TT9MZCQ DMJEXLI MN Enhancer of zeste homolog 2 (EZH2) DMJEXLI MT DTT DMJEXLI MA Inhibitor DMJEXLI RN ClinicalTrials.gov (NCT04104776) A Study of CPI-0209 in Patients With Advanced Tumors. U.S. National Institutes of Health. DMJEXLI RU https://clinicaltrials.gov/ct2/show/NCT04104776 DM3XWJ8 DI DM3XWJ8 DM3XWJ8 DN CPI-1205 DM3XWJ8 MI TT9MZCQ DM3XWJ8 MN Enhancer of zeste homolog 2 (EZH2) DM3XWJ8 MT DTT DM3XWJ8 MA Inhibitor DM3XWJ8 RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DM3XWJ8 RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DM6078F DI DM6078F DM6078F DN CT84.66 DM6078F MI TTY6DTE DM6078F MN Carcinoembryonic antigen CEA (CD66e) DM6078F MT DTT DM6078F RN Technology evaluation: cT84.66, City of Hope. Curr Opin Mol Ther. 2004 Feb;6(1):90-5. DM6078F RU https://pubmed.ncbi.nlm.nih.gov/15011786 DM95XR8 DI DM95XR8 DM95XR8 DN CTCE-9908 DM95XR8 MI TTBID49 DM95XR8 MN C-X-C chemokine receptor type 4 (CXCR4) DM95XR8 MT DTT DM95XR8 MA Modulator DM95XR8 RN A CXCR4 antagonist CTCE-9908 inhibits primary tumor growth and metastasis of breast cancer. J Surg Res. 2009 Aug;155(2):231-6. DM95XR8 RU https://pubmed.ncbi.nlm.nih.gov/19482312 DM90XQC DI DM90XQC DM90XQC DN CTX001 DM90XQC MI TTR61MW DM90XQC MN B-cell lymphoma/leukemia 11A (BCL11A) DM90XQC MT DTT DM90XQC RN Off-the-shelf' allogeneic CAR T cells: development and challenges. Nat Rev Drug Discov. 2020 Mar;19(3):185-199. DM90XQC RU https://pubmed.ncbi.nlm.nih.gov/31900462 DMJ7LP0 DI DMJ7LP0 DMJ7LP0 DN CTX110 DMJ7LP0 MI TTQO71U DMJ7LP0 MN Hemoglobin (HB) DMJ7LP0 MT DTT DMJ7LP0 RN Clinical pipeline report, company report or official report of CRISPR Therapeutics. DMJ7LP0 RU http://www.crisprtx.com/programs/pipeline DMHIQDC DI DMHIQDC DMHIQDC DN CUDC-907 DMHIQDC MI TTBH0VX DMHIQDC MN Histone deacetylase (HDAC) DMHIQDC MT DTT DMHIQDC MA Inhibitor DMHIQDC RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMHIQDC RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DMHIQDC DI DMHIQDC DMHIQDC DN CUDC-907 DMHIQDC MI TTHBTOP DMHIQDC MN PI3-kinase gamma (PIK3CG) DMHIQDC MT DTT DMHIQDC MA Modulator DMHIQDC RN Cancer network disruption by a single molecule inhibitor targeting both histone deacetylase activity and phosphatidylinositol 3-kinase signaling.Clin Cancer Res.2012 Aug 1;18(15):4104-13. DMHIQDC RU https://www.ncbi.nlm.nih.gov/pubmed/22693356 DMCPZYT DI DMCPZYT DMCPZYT DN CV-9201 DMCPZYT MI TTTPU1G DMCPZYT MN Apoptosis inhibitor survivin (BIRC5) DMCPZYT MT DTT DMCPZYT RN National Cancer Institute Drug Dictionary (drug id 648549). DMCPZYT RU http://www.cancer.gov/publications/dictionaries/cancer-drug?cdrid=648549 DMCPZYT DI DMCPZYT DMCPZYT DN CV-9201 DMCPZYT MI TTE5ITK DMCPZYT MN Cancer/testis antigen 1 (NY-ESO-1) DMCPZYT MT DTT DMCPZYT RN National Cancer Institute Drug Dictionary (drug id 648549). DMCPZYT RU http://www.cancer.gov/publications/dictionaries/cancer-drug?cdrid=648549 DMCPZYT DI DMCPZYT DMCPZYT DN CV-9201 DMCPZYT MI TT9M6NA DMCPZYT MN Cancer/testis antigen MAGE-C1/CT7 (MAGEC1) DMCPZYT MT DTT DMCPZYT RN National Cancer Institute Drug Dictionary (drug id 648549). DMCPZYT RU http://www.cancer.gov/publications/dictionaries/cancer-drug?cdrid=648549 DMCPZYT DI DMCPZYT DMCPZYT DN CV-9201 DMCPZYT MI TTKGUEB DMCPZYT MN Melanoma-associated antigen C2 (MAGEC2) DMCPZYT MT DTT DMCPZYT RN National Cancer Institute Drug Dictionary (drug id 648549). DMCPZYT RU http://www.cancer.gov/publications/dictionaries/cancer-drug?cdrid=648549 DMCPZYT DI DMCPZYT DMCPZYT DN CV-9201 DMCPZYT MI TT70MLA DMCPZYT MN Oncotrophoblast glycoprotein 5T4 (TPBG) DMCPZYT MT DTT DMCPZYT RN National Cancer Institute Drug Dictionary (drug id 648549). DMCPZYT RU http://www.cancer.gov/publications/dictionaries/cancer-drug?cdrid=648549 DM03LWZ DI DM03LWZ DM03LWZ DN CVX-060 DM03LWZ MI TTKLQTJ DM03LWZ MN Angiopoietin-2 (ANGPT2) DM03LWZ MT DTT DM03LWZ RN Clinical pipeline report, company report or official report of CovX (2011). DM03LWZ RU http://www.covx.com/pipeline.html DMBUYIK DI DMBUYIK DMBUYIK DN CWP232291 DMBUYIK MI TTFPSHI DMBUYIK MN Wnt signaling pathway (Wnt pathway) DMBUYIK MT DTT DMBUYIK MA Inhibitor DMBUYIK RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMBUYIK RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DMUGMFN DI DMUGMFN DMUGMFN DN CXB-909 DMUGMFN MI TTDN3LF DMUGMFN MN Nerve growth factor (NGF) DMUGMFN MT DTT DMUGMFN MA Modulator DMUGMFN RN Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41. DMUGMFN RU https://www.ncbi.nlm.nih.gov/pubmed/15950434 DME6NMJ DI DME6NMJ DME6NMJ DN CYT-0851 DME6NMJ MI TTC0G1L DME6NMJ MN DNA repair protein RAD51 homolog 1 (RAD51) DME6NMJ MT DTT DME6NMJ MA Inhibitor DME6NMJ RN National Cancer Institute Drug Dictionary (drug name CYT0851). DME6NMJ RU https://www.cancer.gov/publications/dictionaries/cancer-drug/def/rad51-inhibitor-cyt-0851 DMJPSIL DI DMJPSIL DMJPSIL DN Dapivirine DMJPSIL MI DEIBDNY DMJPSIL MN Cytochrome P450 3A5 (CYP3A5) DMJPSIL MT DME DMJPSIL MA Metabolism DMJPSIL RN Metabolism Of Antiretroviral Drugs Used In Hiv Preexposure Prophylaxis DMJPSIL RU https://jscholarship.library.jhu.edu/bitstream/handle/1774.2/39301/TO-DISSERTATION-2014.pdf?sequence=1&isAllowed=y DMJPSIL DI DMJPSIL DMJPSIL DN Dapivirine DMJPSIL MI TT84ETX DMJPSIL MN Human immunodeficiency virus Reverse transcriptase (HIV RT) DMJPSIL MT DTT DMJPSIL MA Inhibitor DMJPSIL RN Emerging antiviral drugs. Expert Opin Emerg Drugs. 2008 Sep;13(3):393-416. DMJPSIL RU https://pubmed.ncbi.nlm.nih.gov/18764719 DMJPSIL DI DMJPSIL DMJPSIL DN Dapivirine DMJPSIL MI DEYGVN4 DMJPSIL MN UDP-glucuronosyltransferase 1A1 (UGT1A1) DMJPSIL MT DME DMJPSIL MA Metabolism DMJPSIL RN Metabolism Of Antiretroviral Drugs Used In Hiv Preexposure Prophylaxis DMJPSIL RU https://jscholarship.library.jhu.edu/bitstream/handle/1774.2/39301/TO-DISSERTATION-2014.pdf?sequence=1&isAllowed=y DMJKFNU DI DMJKFNU DMJKFNU DN DCC-2036 DMJKFNU MI TT9VGXW DMJKFNU MN Angiopoietin 1 receptor (TEK) DMJKFNU MT DTT DMJKFNU MA Inhibitor DMJKFNU RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMJKFNU RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DMJKFNU DI DMJKFNU DMJKFNU DN DCC-2036 DMJKFNU MI TT3PJMV DMJKFNU MN Tyrosine-protein kinase ABL1 (ABL) DMJKFNU MT DTT DMJKFNU MA Modulator DMJKFNU RN Company report (Deciphera Pharmaceuticals: Tumor-Targeted Programs and Indications) DMJKFNU RU http://www.deciphera.com/pipeline DMHW289 DI DMHW289 DMHW289 DN DCC-3014 DMHW289 MI TT7MRDV DMHW289 MN Macrophage colony-stimulating factor 1 receptor (CSF1R) DMHW289 MT DTT DMHW289 MA Inhibitor DMHW289 RN Clinical pipeline report, company report or official report of Deciphera Pharmaceuticals. DMHW289 RU https://www.deciphera.com/pipeline/dcc-3014/ DMWE205 DI DMWE205 DMWE205 DN DCR-MYC DMWE205 MI TTVW4XU DMWE205 MN MYCBP messenger RNA (MYCBP mRNA) DMWE205 MT DTT DMWE205 RN National Cancer Institute Drug Dictionary (drug id 759983). DMWE205 RU http://www.cancer.gov/publications/dictionaries/cancer-drug?cdrid=759983 DM0I5LM DI DM0I5LM DM0I5LM DN DdRNAi therapy rHIV7-shl-TAR-CCR5RZ, stem cells DM0I5LM MI TTJIH8Q DM0I5LM MN CCR5 messenger RNA (CCR5 mRNA) DM0I5LM MT DTT DM0I5LM RN Progress on RNAi-based molecular medicines. Int J Nanomedicine. 2012; 7: 3971-3980. DM0I5LM RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3418169/ DMCMT4V DI DMCMT4V DMCMT4V DN Dexamethasone palmitate DMCMT4V MI DE4LYSA DMCMT4V MN Cytochrome P450 3A4 (CYP3A4) DMCMT4V MT DME DMCMT4V MA Metabolism DMCMT4V RN Cytotoxicity of chloroacetanilide herbicide alachlor in HepG2 cells independent of CYP3A4 and CYP3A7. Food Chem Toxicol. 2007 May;45(5):871-7. DMCMT4V RU https://www.ncbi.nlm.nih.gov/pubmed/?term=17207564 DMCMT4V DI DMCMT4V DMCMT4V DN Dexamethasone palmitate DMCMT4V MI TTPNQAC DMCMT4V MN Estrogen-related receptor-alpha (ESRRA) DMCMT4V MT DTT DMCMT4V MA Agonist DMCMT4V RN Dexamethasone treatment in childhood bacterial meningitis in Malawi: a randomised controlled trial. Lancet. 2002 Jul 20;360(9328):211-8. DMCMT4V RU https://pubmed.ncbi.nlm.nih.gov/12133656 DMACPQO DI DMACPQO DMACPQO DN Dihydrexidine DMACPQO MI TTZFYLI DMACPQO MN Dopamine D1 receptor (D1R) DMACPQO MT DTT DMACPQO MA Inhibitor DMACPQO RN trans-2,3-dihydroxy-6a,7,8,12b-tetrahydro-6H-chromeno[3,4-c]isoquinoline: synthesis, resolution, and preliminary pharmacological characterization o... J Med Chem. 2006 Nov 16;49(23):6848-57. DMACPQO RU https://pubmed.ncbi.nlm.nih.gov/17154515 DM71BFM DI DM71BFM DM71BFM DN DNA-Ad DM71BFM MI TTQZW34 DM71BFM MN Plasmodium Apical membrane protein (Malaria AMA-1) DM71BFM MT DTT DM71BFM RN Sterile immunity to malaria after DNA prime/adenovirus boost immunization is associated with effector memory CD8+T cells targeting AMA1 class I epitopes. PLoS One. 2014 Sep 11;9(9):e106241. DM71BFM RU https://pubmed.ncbi.nlm.nih.gov/25211344 DMK4VY9 DI DMK4VY9 DMK4VY9 DN DS-7300 DMK4VY9 MI TT6CQUM DMK4VY9 MN B7 homolog 3 (CD276) DMK4VY9 MT DTT DMK4VY9 MA Inhibitor DMK4VY9 RN Clinical pipeline report, company report or official report of Daiichi Sankyo. DMK4VY9 RU https://www.daiichisankyo.com/rd/pipeline/ DMK4VY9 DI DMK4VY9 DMK4VY9 DN DS-7300 DMK4VY9 MI TTGTQHC DMK4VY9 MN DNA topoisomerase I (TOP1) DMK4VY9 MT DTT DMK4VY9 MA Inhibitor DMK4VY9 RN Clinical pipeline report, company report or official report of Daiichi Sankyo. DMK4VY9 RU https://www.daiichisankyo.com/rd/pipeline/ DM7WK6N DI DM7WK6N DM7WK6N DN DSP-0509 DM7WK6N MI TTRJ1K4 DM7WK6N MN Toll-like receptor 7 (TLR7) DM7WK6N MT DTT DM7WK6N MA Agonist DM7WK6N RN Clinical pipeline report, company report or official report of Sumitomo Dainippon Pharma. DM7WK6N RU https://www.ds-pharma.com/rd/clinical/pipeline.html DM8K0PR DI DM8K0PR DM8K0PR DN DSP-107 DM8K0PR MI TT28S46 DM8K0PR MN Leukocyte surface antigen CD47 (CD47) DM8K0PR MT DTT DM8K0PR RN Clinical pipeline report, company report or official report of KAHR Medical. DM8K0PR RU https://kahrbio.com/technology/#pipeline DMRXQCL DI DMRXQCL DMRXQCL DN DT388IL-3 DMRXQCL MI TTPYS82 DMRXQCL MN Interleukin 3 receptor (CSF2RB) DMRXQCL MT DTT DMRXQCL MA Inhibitor DMRXQCL RN Safety evaluation of DT388IL3, a diphtheria toxin/interleukin 3 fusion protein, in the cynomolgus monkey. Cancer Immunol Immunother. 2005 Aug;54(8):799-806. DMRXQCL RU https://pubmed.ncbi.nlm.nih.gov/15614527 DM8M71U DI DM8M71U DM8M71U DN DTX301 DM8M71U MI TT5KIO9 DM8M71U MN Ornithine transcarbamylase (OTC) DM8M71U MT DTT DM8M71U MA Replacement DM8M71U RN Clinical pipeline report, company report or official report of Ultragenyx Pharmaceutical. DM8M71U RU https://www.ultragenyx.com/pipeline/dtx-301-for-otc/ DM72DU3 DI DM72DU3 DM72DU3 DN DZD9008 DM72DU3 MI TT2M7YX DM72DU3 MN EGFR Exon20ins mutant (EGFR Exon20ins) DM72DU3 MT DTT DM72DU3 MA Inhibitor DM72DU3 RN Clinical pipeline report, company report or official report of Dizal Pharmaceuticals. DM72DU3 RU http://www.dizalpharma.com/innovation/science DMH2NKD DI DMH2NKD DMH2NKD DN EB-101 DMH2NKD MI TTE4KHA DMH2NKD MN Amyloid beta A4 protein (APP) DMH2NKD MT DTT DMH2NKD RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2402). DMH2NKD RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2402 DMI71FN DI DMI71FN DMI71FN DN EDO-S101 DMI71FN MI TTBH0VX DMI71FN MN Histone deacetylase (HDAC) DMI71FN MT DTT DMI71FN MA Inhibitor DMI71FN RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMI71FN RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DMHRCQI DI DMHRCQI DMHRCQI DN eFT226 DMHRCQI MI TTIGYVZ DMHRCQI MN HUMAN eukaryotic initiation factor-4A (eIF4A) DMHRCQI MT DTT DMHRCQI MA Inhibitor DMHRCQI RN Design of Development Candidate eFT226, a First in Class Inhibitor of Eukaryotic Initiation Factor 4A RNA Helicase. J Med Chem. 2020 Jun 11;63(11):5879-5955. DMHRCQI RU https://pubmed.ncbi.nlm.nih.gov/32470302 DMF7EX8 DI DMF7EX8 DMF7EX8 DN EGFR antisense DNA DMF7EX8 MI TTG96HZ DMF7EX8 MN EGFR messenger RNA (EGFR mRNA) DMF7EX8 MT DTT DMF7EX8 RN Antitumor Effects of EGFR Antisense Guanidine-Based Peptide Nucleic Acids in Cancer Models. ACS Chem Biol. 2013 February 15; 8(2): 345-352. DMF7EX8 RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3684443/ DMDWCOF DI DMDWCOF DMDWCOF DN EGFR CART DMDWCOF MI TTGKNB4 DMDWCOF MN Epidermal growth factor receptor (EGFR) DMDWCOF MT DTT DMDWCOF MA CAR-T-Cell-Therapy DMDWCOF RN ClinicalTrials.gov (NCT03152435) EGFR CART Cells for Patients With Metastatic Colorectal Cancer DMDWCOF RU https://clinicaltrials.gov/ct2/show/NCT03152435 DMC284G DI DMC284G DMC284G DN EGFRvIII CAR DMC284G MI TTZ6B2I DMC284G MN Epidermal growth factor receptor variant III (EGFR vIII) DMC284G MT DTT DMC284G MA Modulator DMC284G RN EGFRvIII mCAR-modified T-cell therapy cures mice with established intracerebral glioma and generates host immunity against tumor-antigen loss. Clin Cancer Res. 2014 Feb 15;20(4):972-84. DMC284G RU https://pubmed.ncbi.nlm.nih.gov/24352643 DM5FCO4 DI DM5FCO4 DM5FCO4 DN Elpamotide DM5FCO4 MI TTUTJGQ DM5FCO4 MN Vascular endothelial growth factor receptor 2 (KDR) DM5FCO4 MT DTT DM5FCO4 RN Clinical phase I study of elpamotide, a peptide vaccine for vascular endothelial growth factor receptor 2, in patients with advanced solid tumors. Cancer Sci. 2012 Dec;103(12):2135-8. DM5FCO4 RU https://pubmed.ncbi.nlm.nih.gov/22957712 DM7CLEZ DI DM7CLEZ DM7CLEZ DN Eltanexor oral DM7CLEZ MI TTCJUR4 DM7CLEZ MN Exportin-1 (XPO1) DM7CLEZ MT DTT DM7CLEZ MA Inhibitor DM7CLEZ RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DM7CLEZ RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DMCAUKW DI DMCAUKW DMCAUKW DN EMB-01 DMCAUKW MI TTGKNB4 DMCAUKW MN Epidermal growth factor receptor (EGFR) DMCAUKW MT DTT DMCAUKW MA Inhibitor DMCAUKW RN Clinical pipeline report, company report or official report of EpimAb Biotherapeutics. DMCAUKW RU https://www.epimab.com/en/pipeline/1 DMMD10S DI DMMD10S DMMD10S DN EMD 55900 DMMD10S MI TTGKNB4 DMMD10S MN Epidermal growth factor receptor (EGFR) DMMD10S MT DTT DMMD10S RN Monoclonal antibodies to target epidermal growth factor receptor-positive tumors: a new paradigm for cancer therapy. Cancer. 2002 Mar 1;94(5):1593-611. DMMD10S RU https://pubmed.ncbi.nlm.nih.gov/11920518 DMIOUFK DI DMIOUFK DMIOUFK DN Emfilermin DMIOUFK MI TTID542 DMIOUFK MN Leukemia inhibitory factor receptor (LIFR) DMIOUFK MT DTT DMIOUFK MA Inhibitor DMIOUFK RN Population pharmacokinetic modelling of Emfilermin (recombinant human leukaemia inhibitory factor, r-hLIF) in healthy postmenopausal women and in infertile patients undergoing in vitro fertilization and embryo transfer. Br J Clin Pharmacol. 2004 May; 57(5): 576-585. DMIOUFK RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1884498/ DM1PQJO DI DM1PQJO DM1PQJO DN Enapotamab vedotin DM1PQJO MI TTZPY6J DM1PQJO MN Tyrosine-protein kinase UFO (AXL) DM1PQJO MT DTT DM1PQJO MA Inhibitor DM1PQJO RN Enapotamab vedotin, an AXL-specific antibody-drug conjugate, shows preclinical antitumor activity in non-small cell lung cancer. JCI Insight. 2019 Nov 1;4(21):e128199. DM1PQJO RU https://pubmed.ncbi.nlm.nih.gov/31600169 DMN0EMP DI DMN0EMP DMN0EMP DN Epicatechin DMN0EMP MI TTSJH2W DMN0EMP MN Mitochondrial protein unspecific (MP) DMN0EMP MT DTT DMN0EMP MA Modulator DMN0EMP RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMN0EMP RU http://phrma-docs.phrma.org/files/dmfile/MID_Neurological-Disorders-Drug-List_2018.pdf DMN0EMP DI DMN0EMP DMN0EMP DN Epicatechin DMN0EMP MI DTFI42L DMN0EMP MN Multidrug resistance-associated protein 2 (ABCC2) DMN0EMP MT DTP DMN0EMP MA Substrate DMN0EMP RN Transport and metabolism of the tea flavonoid (-)-epicatechin by the human intestinal cell line Caco-2. Pharm Res. 2001 Oct;18(10):1420-5. DMN0EMP RU https://doi.org/10.1023/A:1012200805593 DMN0EMP DI DMN0EMP DMN0EMP DN Epicatechin DMN0EMP MI TTPZ7AG DMN0EMP MN Oxidoreductase unspecific (OR) DMN0EMP MT DTT DMN0EMP MA Modulator DMN0EMP RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMN0EMP RU http://phrma-docs.phrma.org/files/dmfile/MID_Neurological-Disorders-Drug-List_2018.pdf DMN0EMP DI DMN0EMP DMN0EMP DN Epicatechin DMN0EMP MI TT8NGED DMN0EMP MN Prostaglandin G/H synthase 1 (COX-1) DMN0EMP MT DTT DMN0EMP MA Inhibitor DMN0EMP RN Mechanism-based inactivation of COX-1 by red wine m-hydroquinones: a structure-activity relationship study. J Nat Prod. 2004 Nov;67(11):1777-82. DMN0EMP RU https://pubmed.ncbi.nlm.nih.gov/15568761 DMWSGZU DI DMWSGZU DMWSGZU DN Epithalon DMWSGZU MI TTUJFD0 DMWSGZU MN Telomerase reverse transcriptase (TERT) DMWSGZU MT DTT DMWSGZU MA Modulator DMWSGZU RN Epithalon peptide induces telomerase activity and telomere elongation in human somatic cells. Bull Exp Biol Med. 2003 Jun;135(6):590-2. DMWSGZU RU https://pubmed.ncbi.nlm.nih.gov/12937682 DMTY96S DI DMTY96S DMTY96S DN Eptacog beta DMTY96S MI TTLPJWH DMTY96S MN Thioredoxin reductase (PRDX5) DMTY96S MT DTT DMTY96S MA Inhibitor DMTY96S RN APR-246/PRIMA-1MET inhibits thioredoxin reductase 1 and converts the enzyme to a dedicated NADPH oxidase. Cell Death Dis. 2013 Oct 24;4:e881. DMTY96S RU https://pubmed.ncbi.nlm.nih.gov/24157875 DMN2FS3 DI DMN2FS3 DMN2FS3 DN EPZ-5676 DMN2FS3 MI TTSZ8T1 DMN2FS3 MN Histone-lysine N-methyltransferase (HLNM) DMN2FS3 MT DTT DMN2FS3 MA Modulator DMN2FS3 RN Potent inhibition of DOT1L as treatment of MLL-fusion leukemia. Blood. 2013 August 8; 122(6): 1017-1025. DMN2FS3 RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3739029/ DMNZ6VA DI DMNZ6VA DMNZ6VA DN Erythropoietin-transfected autologous cell therapy DMNZ6VA MI TTQG4NR DMNZ6VA MN Erythropoietin (EPO) DMNZ6VA MT DTT DMNZ6VA MA Modulator DMNZ6VA RN Mesenchymal stromal cells engineered to express erythropoietin induce anti-erythropoietin antibodies and anemia in allorecipients. Mol Ther. 2009 Feb;17(2):369-72. DMNZ6VA RU https://pubmed.ncbi.nlm.nih.gov/19088705 DMUNM4D DI DMUNM4D DMUNM4D DN ESR0114 DMUNM4D MI TTGV6LY DMUNM4D MN Nuclear receptor ROR-gamma (RORG) DMUNM4D MT DTT DMUNM4D MA Inhibitor DMUNM4D RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMUNM4D RU http://phrma-docs.phrma.org/files/dmfile/MID_Skin_Diseases_2018_9_FINAL.pdf DMIREUZ DI DMIREUZ DMIREUZ DN Ex vivo adenosine deaminase-transduced hematopoietic stem cell therapy DMIREUZ MI TTLP57V DMIREUZ MN Adenosine deaminase (ADA) DMIREUZ MT DTT DMIREUZ MA Modulator DMIREUZ RN Clinical pipeline report, company report or official report of GlaxoSmithKline. DMIREUZ RU https://www.gsk.com/en-gb/media/press-releases/2015/gsk-fondazione-telethon-and-ospedale-san-raffaele-announce-eu-regulatory-submission-for-gene-therapy-to-treat-rare-disease-ada-scid/ DM64PM7 DI DM64PM7 DM64PM7 DN EXO-230 DM64PM7 MI TT8NGED DM64PM7 MN Prostaglandin G/H synthase 1 (COX-1) DM64PM7 MT DTT DM64PM7 MA Agonist DM64PM7 RN Inhibiting Amadori-modified albumin formation improves biomarkers of podocyte damage in diabetic rats. Physiol Rep. 2013 September; 1(4): e00083. DM64PM7 RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3831899/ DML6EVJ DI DML6EVJ DML6EVJ DN F-14512 DML6EVJ MI TT0IHXV DML6EVJ MN DNA topoisomerase II (TOP2) DML6EVJ MT DTT DML6EVJ MA Modulator DML6EVJ RN Regulation by survivin of cancer cell death induced by F14512, a polyamine-containing inhibitor of DNA topoisomerase II.Apoptosis.2012 Apr;17(4):364-76. DML6EVJ RU https://www.ncbi.nlm.nih.gov/pubmed/22127645 DM49BX1 DI DM49BX1 DM49BX1 DN F-16-131I DM49BX1 MI TTUCPMY DM49BX1 MN Tenascin (TNC) DM49BX1 MT DTT DM49BX1 RN Tumor-Associated Fibroblasts and their Matrix. Springer. Margareta M. Mueller,Norbert E. Fusenig, 2011. Page(775). DM49BX1 RU https://books.google.com.hk/books?id=NthWAAAAcAAJ&pg=PA775&lpg=PA775&dq=%22F-16-131I%22&source=bl&ots=lx9eNOrJ9J&sig=TSJZ44F1Vb9V3iKhqn2bmzR0H4E&hl=zh-CN&sa=X&ved=0CBoQ6AEwAGoVChMIgayw4crGyAIVDEiOCh1b7Q2U#v=onepage&q=%22F-16-131I%22&f=false DMQSF5C DI DMQSF5C DMQSF5C DN FBT-A05 DMQSF5C MI TTUE541 DMQSF5C MN Leukocyte surface antigen Leu-16 (CD20) DMQSF5C MT DTT DMQSF5C RN Immunotherapy with FBTA05 (Bi20), a trifunctional bispecific anti-CD3 x anti-CD20 antibody and donor lymphocyte infusion (DLI) in relapsed or refractory B-cell lymphoma after allogeneic stem cell transplantation: study protocol of an investigator-driven, open-label, non-randomized, uncontrolled, dose-escalating Phase I/II-trial. J Transl Med. 2013 Jul 2;11:160. DMQSF5C RU https://pubmed.ncbi.nlm.nih.gov/23815981 DMQ8VUW DI DMQ8VUW DMQ8VUW DN FCN-437 DMQ8VUW MI TT0PG8F DMQ8VUW MN Cyclin-dependent kinase 4 (CDK4) DMQ8VUW MT DTT DMQ8VUW MA Inhibitor DMQ8VUW RN Clinical pipeline report, company report or official report of Fochon Pharmaceuticals. DMQ8VUW RU http://fochon.com/what-we-do/fcn-411/ DMQ8VUW DI DMQ8VUW DMQ8VUW DN FCN-437 DMQ8VUW MI TTO0FDJ DMQ8VUW MN Cyclin-dependent kinase 6 (CDK6) DMQ8VUW MT DTT DMQ8VUW MA Inhibitor DMQ8VUW RN Clinical pipeline report, company report or official report of Fochon Pharmaceuticals. DMQ8VUW RU http://fochon.com/what-we-do/fcn-411/ DMRHOFB DI DMRHOFB DMRHOFB DN Ferritarg P DMRHOFB MI TT975ZT DMRHOFB MN Ferritin (FTH1) DMRHOFB MT DTT DMRHOFB RN Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800019964) DMRHOFB RU http://adisinsight.springer.com/drugs/800019964 DM1XIMU DI DM1XIMU DM1XIMU DN FF-10101 DM1XIMU MI TTGJCWZ DM1XIMU MN Fms-like tyrosine kinase 3 (FLT-3) DM1XIMU MT DTT DM1XIMU MA Inhibitor DM1XIMU RN A novel irreversible FLT3 inhibitor, FF-10101, shows excellent efficacy against AML cells with FLT3 mutations. Blood. 2018 Jan 25;131(4):426-438. DM1XIMU RU https://pubmed.ncbi.nlm.nih.gov/29187377 DM0HSJK DI DM0HSJK DM0HSJK DN FF-10501-01 DM0HSJK MI TTF63Z1 DM0HSJK MN Cell differentiation (CD) DM0HSJK MT DTT DM0HSJK MA Stimulator DM0HSJK RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DM0HSJK RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DM72JE4 DI DM72JE4 DM72JE4 DN FF-10502 DM72JE4 MI TTA0XPV DM72JE4 MN DNA polymerase beta (POLB) DM72JE4 MT DTT DM72JE4 MA Inhibitor DM72JE4 RN FF-10502, an Antimetabolite with Novel Activity on Dormant Cells, Is Superior to Gemcitabine for Targeting Pancreatic Cancer Cells. J Pharmacol Exp Ther. 2018 Jul;366(1):125-135. DM72JE4 RU https://pubmed.ncbi.nlm.nih.gov/29653962 DMWEJ0C DI DMWEJ0C DMWEJ0C DN FGF401 DMWEJ0C MI TT1KX2S DMWEJ0C MN FGFR4 messenger RNA (FGFR4 mRNA) DMWEJ0C MT DTT DMWEJ0C MA Antagonist DMWEJ0C RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMWEJ0C RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DMI7S39 DI DMI7S39 DMI7S39 DN FLX475 DMI7S39 MI TT7HQD0 DMI7S39 MN C-C chemokine receptor type 4 (CCR4) DMI7S39 MT DTT DMI7S39 MA Antagonist DMI7S39 RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMI7S39 RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DME2W4T DI DME2W4T DME2W4T DN Forodesine DME2W4T MI TTMCF1Y DME2W4T MN Purine nucleoside phosphorylase (PNP) DME2W4T MT DTT DME2W4T MA Inhibitor DME2W4T RN Forodesine has high antitumor activity in chronic lymphocytic leukemia and activates p53-independent mitochondrial apoptosis by induction of p73 an... Blood. 2009 Aug 20;114(8):1563-75. DME2W4T RU https://pubmed.ncbi.nlm.nih.gov/19541822 DM3ZN6Y DI DM3ZN6Y DM3ZN6Y DN FPA-008 DM3ZN6Y MI TT731LW DM3ZN6Y MN Colony stimulating factor-1 receptor (CSF-1R) DM3ZN6Y MT DTT DM3ZN6Y MA Modulator DM3ZN6Y RN Company report (Five Prime Therapeutics) DM3ZN6Y RU http://www.fiveprime.com/pipeline/fpa008 DM3ZN6Y DI DM3ZN6Y DM3ZN6Y DN FPA-008 DM3ZN6Y MI TT7MRDV DM3ZN6Y MN Macrophage colony-stimulating factor 1 receptor (CSF1R) DM3ZN6Y MT DTT DM3ZN6Y RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DM3ZN6Y RU http://phrma-docs.phrma.org/sites/default/files/pdf/medicines-in-development-drug-list-rare-diseases.pdf DMXV6YP DI DMXV6YP DMXV6YP DN Fus-1 tumor suppressor gene therapy DMXV6YP MI TTJ8O14 DMXV6YP MN Tumor suppressor candidate 2 (TUSC2) DMXV6YP MT DTT DMXV6YP MA Suppressor DMXV6YP RN INGN 201: Ad-p53, Ad5CMV-p53, adenoviral p53, p53 gene therapy--introgen, RPR/INGN 201. Drugs R D. 2007;8(3):176-87. DMXV6YP RU https://pubmed.ncbi.nlm.nih.gov/17472413 DMG48WN DI DMG48WN DMG48WN DN G0-203-2c DMG48WN MI TTBHFYQ DMG48WN MN Mucin-1 (MUC1) DMG48WN MT DTT DMG48WN MA Modulator DMG48WN RN Clinical pipeline report, company report or official report of Genus Oncology. DMG48WN RU http://www.genusoncology.com/phase-1-trial-GO-203-2c.php DMTV42K DI DMTV42K DMTV42K DN G1 DMTV42K MI TTDSB34 DMTV42K MN G-protein coupled estrogen receptor 1 (GPER1) DMTV42K MT DTT DMTV42K MA Agonist DMTV42K RN Virtual and biomolecular screening converge on a selective agonist for GPR30. Nat Chem Biol. 2006 Apr;2(4):207-12. DMTV42K RU https://pubmed.ncbi.nlm.nih.gov/16520733 DM32AKH DI DM32AKH DM32AKH DN G-207 virus construct DM32AKH MI TTX09M4 DM32AKH MN Ribonucleotide reductase (RIR) DM32AKH MT DTT DM32AKH MA Inhibitor DM32AKH RN Anti-tumor effect of oncolytic herpes simplex virus G47delta on human nasopharyngeal carcinoma. Chin J Cancer. 2011 Dec;30(12):831-41. DM32AKH RU https://pubmed.ncbi.nlm.nih.gov/22059912 DMQU4EI DI DMQU4EI DMQU4EI DN Galnobax DMQU4EI MI TTR6W5O DMQU4EI MN Adrenergic receptor beta-1 (ADRB1) DMQU4EI MT DTT DMQU4EI MA Agonist DMQU4EI RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMQU4EI RU http://phrma-docs.phrma.org/files/dmfile/mid-diabetes-drug-list.pdf DMN7QBE DI DMN7QBE DMN7QBE DN GANTACURIUM CHLORIDE DMN7QBE MI TTJSZTB DMN7QBE MN Nicotinic acetylcholine receptor (nAChR) DMN7QBE MT DTT DMN7QBE MA Modulator DMN7QBE RN Gantacurium and CW002 do not potentiate muscarinic receptor-mediated airway smooth muscle constriction in guinea pigs. Anesthesiology. 2010 April; 112(4): 892-899. DMN7QBE RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2854830/ DMCT9NG DI DMCT9NG DMCT9NG DN GB1275 DMCT9NG MI TTB69FJ DMCT9NG MN Integrin alpha-M (ITGAM) DMCT9NG MT DTT DMCT9NG MA Agonist DMCT9NG RN National Cancer Institute Drug Dictionary (drug name GB1275). DMCT9NG RU https://www.cancer.gov/publications/dictionaries/cancer-drug/def/cd11b-agonist-gb1275 DM5VF04 DI DM5VF04 DM5VF04 DN GD2-CART01 DM5VF04 MI TT80ARU DM5VF04 MN Ganglioside GD2 (GD2) DM5VF04 MT DTT DM5VF04 MA CAR-T-Cell-Therapy DM5VF04 RN ClinicalTrials.gov (NCT03373097) Anti-GD2 CAR T Cells in Pediatric Patients Affected by High Risk and/or Relapsed/Refractory Neuroblastoma DM5VF04 RU https://clinicaltrials.gov/ct2/show/NCT03373097 DM8J0MK DI DM8J0MK DM8J0MK DN GEA-6414 DM8J0MK MI DE4OGUF DM8J0MK MN Cytochrome P450 102A1 (cyp102) DM8J0MK MT DME DM8J0MK MA Metabolism DM8J0MK RN Both reactivity and accessibility are important in cytochrome P450 metabolism: a combined DFT and MD study of fenamic acids in BM3 mutants. J Chem Inf Model. 2019 Feb 25;59(2):743-753. DM8J0MK RU https://pubmed.ncbi.nlm.nih.gov/30758202 DM8J0MK DI DM8J0MK DM8J0MK DN GEA-6414 DM8J0MK MI DE4LYSA DM8J0MK MN Cytochrome P450 3A4 (CYP3A4) DM8J0MK MT DME DM8J0MK MA Metabolism DM8J0MK RN Integrated analysis on the physicochemical properties of dihydropyridine calcium channel blockers in grapefruit juice interactions. Curr Pharm Biotechnol. 2012 Jul;13(9):1705-17. DM8J0MK RU https://www.ncbi.nlm.nih.gov/pubmed/?term=22039822 DMD8RLY DI DMD8RLY DMD8RLY DN GEN3009 DMD8RLY MI TTFCW29 DMD8RLY MN Leukocyte antigen CD37 (CD37) DMD8RLY MT DTT DMD8RLY RN Clinical pipeline report, company report or official report of AbbVie. DMD8RLY RU https://www.abbvie.com/our-science/pipeline/gen-3009.html DMZABYH DI DMZABYH DMZABYH DN GEN3013 DMZABYH MI TTUE541 DMZABYH MN Leukocyte surface antigen Leu-16 (CD20) DMZABYH MT DTT DMZABYH RN DuoBody-CD3xCD20 induces potent T-cell-mediated killing of malignant B cells in preclinical models and provides opportunities for subcutaneous dosing. EBioMedicine. 2020 Feb;52:102625. DMZABYH RU https://pubmed.ncbi.nlm.nih.gov/31981978 DMZABYH DI DMZABYH DMZABYH DN GEN3013 DMZABYH MI TTUN7MC DMZABYH MN T-cell surface glycoprotein CD3 (CD3) DMZABYH MT DTT DMZABYH RN DuoBody-CD3xCD20 induces potent T-cell-mediated killing of malignant B cells in preclinical models and provides opportunities for subcutaneous dosing. EBioMedicine. 2020 Feb;52:102625. DMZABYH RU https://pubmed.ncbi.nlm.nih.gov/31981978 DMY1CP9 DI DMY1CP9 DMY1CP9 DN GLG-801 DMY1CP9 MI TTH8FZW DMY1CP9 MN Signal transducer and activator of transcription 3 (STAT3) DMY1CP9 MT DTT DMY1CP9 MA Inhibitor DMY1CP9 RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMY1CP9 RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DM7DWLY DI DM7DWLY DM7DWLY DN GLR2007 DM7DWLY MI TT0PG8F DM7DWLY MN Cyclin-dependent kinase 4 (CDK4) DM7DWLY MT DTT DM7DWLY MA Inhibitor DM7DWLY RN Clinical pipeline report, company report or official report of Gan & Lee Pharmaceuticals. DM7DWLY RU http://www.ganlee.com/en/index.php?optionid=681&auto_id=68 DM7DWLY DI DM7DWLY DM7DWLY DN GLR2007 DM7DWLY MI TTO0FDJ DM7DWLY MN Cyclin-dependent kinase 6 (CDK6) DM7DWLY MT DTT DM7DWLY MA Inhibitor DM7DWLY RN Clinical pipeline report, company report or official report of Gan & Lee Pharmaceuticals. DM7DWLY RU http://www.ganlee.com/en/index.php?optionid=681&auto_id=68 DMGN679 DI DMGN679 DMGN679 DN GPC3-CART cells DMGN679 MI TTJTSX4 DMGN679 MN Glypican-3 (GPC3) DMGN679 MT DTT DMGN679 MA CAR-T-Cell-Therapy DMGN679 RN ClinicalTrials.gov (NCT03130712) A Study of GPC3-targeted T Cells by Intratumor Injection for Advanced HCC (GPC3-CART) DMGN679 RU https://clinicaltrials.gov/ct2/show/NCT03130712 DM1GE67 DI DM1GE67 DM1GE67 DN GS-4224 DM1GE67 MI TT8ZLTI DM1GE67 MN Programmed cell death 1 ligand 1 (PD-L1) DM1GE67 MT DTT DM1GE67 MA Inhibitor DM1GE67 RN Clinical pipeline report, company report or official report of Gilead Sciences. DM1GE67 RU https://www.gilead.com/science-and-medicine/pipeline DMTJQ8S DI DMTJQ8S DMTJQ8S DN GS-9219 DMTJQ8S MI TTIU7X1 DMTJQ8S MN Herpes simplex virus DNA polymerase UL30 (HSV UL30) DMTJQ8S MT DTT DMTJQ8S MA Inhibitor DMTJQ8S RN GS-9219--a novel acyclic nucleotide analogue with potent antineoplastic activity in dogs with spontaneous non-Hodgkin's lymphoma. Clin Cancer Res. 2008 May 1;14(9):2824-32. DMTJQ8S RU https://pubmed.ncbi.nlm.nih.gov/18451250 DM059OH DI DM059OH DM059OH DN GSK3145095 DM059OH MI TTAIQSN DM059OH MN Receptor-interacting protein 1 (RIPK1) DM059OH MT DTT DM059OH MA Inhibitor DM059OH RN Identification of a RIP1 Kinase Inhibitor Clinical Candidate (GSK3145095) for the Treatment of Pancreatic Cancer. ACS Med Chem Lett. 2019 May 9;10(6):857-862. DM059OH RU https://pubmed.ncbi.nlm.nih.gov/31223438 DMK2RIB DI DMK2RIB DMK2RIB DN GTB-3550 DMK2RIB MI TT7KTSR DMK2RIB MN Immunoglobulin gamma Fc receptor III (FCGR3) DMK2RIB MT DTT DMK2RIB MA Inhibitor DMK2RIB RN Clinical pipeline report, company report or official report of GT Biopharma. DMK2RIB RU https://www.gtbiopharma.com/product-pipeline/gtb-3550 DMK2RIB DI DMK2RIB DMK2RIB DN GTB-3550 DMK2RIB MI TTJVYO3 DMK2RIB MN Myeloid cell surface antigen CD33 (CD33) DMK2RIB MT DTT DMK2RIB MA Inhibitor DMK2RIB RN Clinical pipeline report, company report or official report of GT Biopharma. DMK2RIB RU https://www.gtbiopharma.com/product-pipeline/gtb-3550 DM0S24D DI DM0S24D DM0S24D DN GTU-TB vaccine DM0S24D MI TTUTN1I DM0S24D MN Human Deoxyribonucleic acid (hDNA) DM0S24D MT DTT DM0S24D RN Clinical pipeline report, company report or official report of hightechfinland. DM0S24D RU http://www.hightechfinland.com/wwwdata/pdf/2013/Fitbiotech.pdf DMIFCY2 DI DMIFCY2 DMIFCY2 DN H3B-6545 DMIFCY2 MI DEJGDUW DMIFCY2 MN Cytochrome P450 1A2 (CYP1A2) DMIFCY2 MT DME DMIFCY2 MA Metabolism DMIFCY2 RN Nonclinical pharmacokinetics and in vitro metabolism of H3B-6545, a novel selective ERalpha covalent antagonist (SERCA). Cancer Chemother Pharmacol. 2019 Jan;83(1):151-160. DMIFCY2 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=30386887 DMIFCY2 DI DMIFCY2 DMIFCY2 DN H3B-6545 DMIFCY2 MI DEPKLMQ DMIFCY2 MN Cytochrome P450 2B6 (CYP2B6) DMIFCY2 MT DME DMIFCY2 MA Metabolism DMIFCY2 RN Nonclinical pharmacokinetics and in vitro metabolism of H3B-6545, a novel selective ERalpha covalent antagonist (SERCA). Cancer Chemother Pharmacol. 2019 Jan;83(1):151-160. DMIFCY2 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=30386887 DMIFCY2 DI DMIFCY2 DMIFCY2 DN H3B-6545 DMIFCY2 MI DES5XRU DMIFCY2 MN Cytochrome P450 2C8 (CYP2C8) DMIFCY2 MT DME DMIFCY2 MA Metabolism DMIFCY2 RN Nonclinical pharmacokinetics and in vitro metabolism of H3B-6545, a novel selective ERalpha covalent antagonist (SERCA). Cancer Chemother Pharmacol. 2019 Jan;83(1):151-160. DMIFCY2 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=30386887 DMIFCY2 DI DMIFCY2 DMIFCY2 DN H3B-6545 DMIFCY2 MI DE5IED8 DMIFCY2 MN Cytochrome P450 2C9 (CYP2C9) DMIFCY2 MT DME DMIFCY2 MA Metabolism DMIFCY2 RN Nonclinical pharmacokinetics and in vitro metabolism of H3B-6545, a novel selective ERalpha covalent antagonist (SERCA). Cancer Chemother Pharmacol. 2019 Jan;83(1):151-160. DMIFCY2 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=30386887 DMIFCY2 DI DMIFCY2 DMIFCY2 DN H3B-6545 DMIFCY2 MI DECB0K3 DMIFCY2 MN Cytochrome P450 2D6 (CYP2D6) DMIFCY2 MT DME DMIFCY2 MA Metabolism DMIFCY2 RN Nonclinical pharmacokinetics and in vitro metabolism of H3B-6545, a novel selective ERalpha covalent antagonist (SERCA). Cancer Chemother Pharmacol. 2019 Jan;83(1):151-160. DMIFCY2 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=30386887 DMIFCY2 DI DMIFCY2 DMIFCY2 DN H3B-6545 DMIFCY2 MI DERSX5P DMIFCY2 MN Cytochrome P450 2J2 (CYP2J2) DMIFCY2 MT DME DMIFCY2 MA Metabolism DMIFCY2 RN Nonclinical pharmacokinetics and in vitro metabolism of H3B-6545, a novel selective ERalpha covalent antagonist (SERCA). Cancer Chemother Pharmacol. 2019 Jan;83(1):151-160. DMIFCY2 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=30386887 DMIFCY2 DI DMIFCY2 DMIFCY2 DN H3B-6545 DMIFCY2 MI DE4LYSA DMIFCY2 MN Cytochrome P450 3A4 (CYP3A4) DMIFCY2 MT DME DMIFCY2 MA Metabolism DMIFCY2 RN Nonclinical pharmacokinetics and in vitro metabolism of H3B-6545, a novel selective ERalpha covalent antagonist (SERCA). Cancer Chemother Pharmacol. 2019 Jan;83(1):151-160. DMIFCY2 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=30386887 DMIFCY2 DI DMIFCY2 DMIFCY2 DN H3B-6545 DMIFCY2 MI DEIBDNY DMIFCY2 MN Cytochrome P450 3A5 (CYP3A5) DMIFCY2 MT DME DMIFCY2 MA Metabolism DMIFCY2 RN Nonclinical pharmacokinetics and in vitro metabolism of H3B-6545, a novel selective ERalpha covalent antagonist (SERCA). Cancer Chemother Pharmacol. 2019 Jan;83(1):151-160. DMIFCY2 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=30386887 DMIFCY2 DI DMIFCY2 DMIFCY2 DN H3B-6545 DMIFCY2 MI TTZAYWL DMIFCY2 MN Estrogen receptor (ESR) DMIFCY2 MT DTT DMIFCY2 MA Antagonist DMIFCY2 RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMIFCY2 RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DMIFCY2 DI DMIFCY2 DMIFCY2 DN H3B-6545 DMIFCY2 MI DEGTFWK DMIFCY2 MN Mephenytoin 4-hydroxylase (CYP2C19) DMIFCY2 MT DME DMIFCY2 MA Metabolism DMIFCY2 RN Nonclinical pharmacokinetics and in vitro metabolism of H3B-6545, a novel selective ERalpha covalent antagonist (SERCA). Cancer Chemother Pharmacol. 2019 Jan;83(1):151-160. DMIFCY2 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=30386887 DMQWI7V DI DMQWI7V DMQWI7V DN Hematopoietic stem cell gene therapy DMQWI7V MI TTE8T73 DMQWI7V MN Wiskott-Aldrich syndrome protein (WAS) DMQWI7V MT DTT DMQWI7V MA Modulator DMQWI7V RN Development of hematopoietic stem cell gene therapy for Wiskott-Aldrich syndrome. Curr Opin Mol Ther. 2006 Oct;8(5):390-5. DMQWI7V RU https://pubmed.ncbi.nlm.nih.gov/17078381 DM1U6VX DI DM1U6VX DM1U6VX DN HER-2-targeting CAR T Cells DM1U6VX MI TT6EO5L DM1U6VX MN Erbb2 tyrosine kinase receptor (HER2) DM1U6VX MT DTT DM1U6VX MA CAR-T-Cell-Therapy DM1U6VX RN ClinicalTrials.gov (NCT02547961) Chimeric Antigen Receptor-Modified T Cells for Breast Cancer DM1U6VX RU https://clinicaltrials.gov/ct2/show/NCT02547961 DM0C5MV DI DM0C5MV DM0C5MV DN HH2710 DM0C5MV MI TT1MG9E DM0C5MV MN Extracellular signal-regulated kinase 1 (ERK1) DM0C5MV MT DTT DM0C5MV MA Inhibitor DM0C5MV RN Clinical pipeline report, company report or official report of HaiHe Biopharma. DM0C5MV RU https://www.haihepharma.com/en/research DM0C5MV DI DM0C5MV DM0C5MV DN HH2710 DM0C5MV MI TT4TQBX DM0C5MV MN Extracellular signal-regulated kinase 2 (ERK2) DM0C5MV MT DTT DM0C5MV MA Inhibitor DM0C5MV RN Clinical pipeline report, company report or official report of HaiHe Biopharma. DM0C5MV RU https://www.haihepharma.com/en/research DMJDVCW DI DMJDVCW DMJDVCW DN HL-085 DMJDVCW MI TTZCRP3 DMJDVCW MN ERK activator kinase (MEK) DMJDVCW MT DTT DMJDVCW MA Inhibitor DMJDVCW RN Current Development Status of MEK Inhibitors. Molecules. 2017 Sep 26;22(10):1551. DMJDVCW RU https://pubmed.ncbi.nlm.nih.gov/28954413 DMDFG1O DI DMDFG1O DMDFG1O DN HLF 1-11 DMDFG1O MI TTSZDQU DMDFG1O MN Lactotransferrin (LTF) DMDFG1O MT DTT DMDFG1O MA Modulator DMDFG1O RN The synthetic N-terminal peptide of human lactoferrin, hLF(1-11), is highly effective against experimental infection caused by multidrug-resistant Acinetobacter baumannii. Antimicrob Agents Chemother. 2004 Dec;48(12):4919-21. DMDFG1O RU https://pubmed.ncbi.nlm.nih.gov/15561882 DMV1SDA DI DMV1SDA DMV1SDA DN HM43239 DMV1SDA MI TTGJCWZ DMV1SDA MN Fms-like tyrosine kinase 3 (FLT-3) DMV1SDA MT DTT DMV1SDA MA Inhibitor DMV1SDA RN Clinical pipeline report, company report or official report of Hanmi Pharmaceutical. DMV1SDA RU https://www.hanmipharm.com/ehanmi/handler/Rnd-FocusedPipelineD DMV1SDA DI DMV1SDA DMV1SDA DN HM43239 DMV1SDA MI TTOU65C DMV1SDA MN Tyrosine-protein kinase SYK (SYK) DMV1SDA MT DTT DMV1SDA MA Inhibitor DMV1SDA RN Clinical pipeline report, company report or official report of Hanmi Pharmaceutical. DMV1SDA RU https://www.hanmipharm.com/ehanmi/handler/Rnd-FocusedPipelineD DM1ZHML DI DM1ZHML DM1ZHML DN HPN328 DM1ZHML MI TT1C9K6 DM1ZHML MN Delta-like protein 3 (DLL3) DM1ZHML MT DTT DM1ZHML RN Clinical pipeline report, company report or official report of Harpoon Therapeutics. DM1ZHML RU https://www.harpoontx.com/pipeline/ DM86OJ0 DI DM86OJ0 DM86OJ0 DN HPN536 DM86OJ0 MI TT4RXME DM86OJ0 MN Mesothelin (MSLN) DM86OJ0 MT DTT DM86OJ0 RN Clinical pipeline report, company report or official report of Harpoon Therapeutics. DM86OJ0 RU https://www.harpoontx.com/pipeline/ DMEY1AP DI DMEY1AP DMEY1AP DN HSDB-3165 DMEY1AP MI DEULQ45 DMEY1AP MN Sodium/potassium-transporting ATPase gamma (FXYD2) DMEY1AP MT DME DMEY1AP MA Metabolism DMEY1AP RN Rare mutations in renal sodium and potassium transporter genes exhibit impaired transport function. Curr Opin Nephrol Hypertens. 2014 Jan;23(1):1-8. DMEY1AP RU https://www.ncbi.nlm.nih.gov/pubmed/?term=24253496 DM7C1AJ DI DM7C1AJ DM7C1AJ DN HT-2157 DM7C1AJ MI TTOPAY7 DM7C1AJ MN Galanin receptor (GAL-R) DM7C1AJ MT DTT DM7C1AJ MA Antagonist DM7C1AJ RN Anxiolytic- and antidepressant-like profiles of the galanin-3 receptor (Gal3) antagonists SNAP 37889 and SNAP 398299. Proc Natl Acad Sci U S A. 2005 Nov 29;102(48):17489-94. DM7C1AJ RU https://pubmed.ncbi.nlm.nih.gov/16287967 DMNHE43 DI DMNHE43 DMNHE43 DN HTU-PA DMNHE43 MI TTGY7WI DMNHE43 MN Urokinase-type plasminogen activator (PLAU) DMNHE43 MT DTT DMNHE43 MA Activator DMNHE43 RN Characterization of the dexamethasone-induced inhibitor of plasminogen activator in HTC hepatoma cells. J Biol Chem. 1986 Mar 25;261(9):4352-7. DMNHE43 RU https://pubmed.ncbi.nlm.nih.gov/2936742 DMIU1HY DI DMIU1HY DMIU1HY DN HuM-195-Ac-225 DMIU1HY MI TTJVYO3 DMIU1HY MN Myeloid cell surface antigen CD33 (CD33) DMIU1HY MT DTT DMIU1HY MA Inhibitor DMIU1HY RN J Clin Oncol 29: 2011 (suppl; abstr 6516). DMIU1HY RU http://meetinglibrary.asco.org/content/77232-102 DMOVF6E DI DMOVF6E DMOVF6E DN Humanized CD19 CAR-T cells DMOVF6E MI TTW640A DMOVF6E MN B-lymphocyte surface antigen B4 (CD19) DMOVF6E MT DTT DMOVF6E MA CAR-T-Cell-Therapy DMOVF6E RN ClinicalTrials.gov (NCT03275493) Humanized CD19 CAR-T Cells With CRS Suppression Technology for r/r CD19+ Acute Lymphoblastic Leukemia DMOVF6E RU https://clinicaltrials.gov/ct2/show/NCT03275493 DM7U458 DI DM7U458 DM7U458 DN IDX-184 DM7U458 MI TTE3PC9 DM7U458 MN Hepatitis C virus Non-structural 5 (HCV NS5) DM7U458 MT DTT DM7U458 MA Inhibitor DM7U458 RN Genotype and Subtype Profiling of PSI-7977 as a Nucleotide Inhibitor of Hepatitis C Virus. Antimicrob Agents Chemother. 2012 June; 56(6): 3359-3368. DM7U458 RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3370800/ DMLEVFW DI DMLEVFW DMLEVFW DN IFN alpha kinoid DMLEVFW MI TT95SOA DMLEVFW MN Interferon alpha (IFNA) DMLEVFW MT DTT DMLEVFW MA Modulator DMLEVFW RN Down-regulation of interferon signature in systemic lupus erythematosus patients by active immunization with interferon alpha-kinoid. Arthritis Rheum. 2013 Feb;65(2):447-56. DMLEVFW RU https://pubmed.ncbi.nlm.nih.gov/23203821 DM1CG47 DI DM1CG47 DM1CG47 DN IL-2 XL DM1CG47 MI TTF89GD DM1CG47 MN Interleukin-2 (IL2) DM1CG47 MT DTT DM1CG47 MA Modulator DM1CG47 RN Pharmacokinetics (PK) and immunologic responses in a phase I/II study of a sustained release formulation of IL-2 in renal cell carcinoma (RCC) patients. J Clin Oncol (Meeting Abstracts) June 2006 vol. 24 no. 18_suppl 2558. DM1CG47 RU http://meeting.ascopubs.org/cgi/content/short/24/18_suppl/2558 DMJ9CY4 DI DMJ9CY4 DMJ9CY4 DN IL-2/gene-modified lymphocytes DMJ9CY4 MI TTF89GD DMJ9CY4 MN Interleukin-2 (IL2) DMJ9CY4 MT DTT DMJ9CY4 MA Modulator DMJ9CY4 RN Genetic modification of human T lymphocytes for the treatment of hematologic malignancies. Haematologica. 2012 November; 97(11): 1622-1631. DMJ9CY4 RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3487433/ DMKV5D6 DI DMKV5D6 DMKV5D6 DN IM19 CAR-T DMKV5D6 MI TTW640A DMKV5D6 MN B-lymphocyte surface antigen B4 (CD19) DMKV5D6 MT DTT DMKV5D6 MA CAR-T-Cell-Therapy DMKV5D6 RN ClinicalTrials.gov (NCT03142646) Safety and Efficacy Evaluation of IM19 CAR-T Cells DMKV5D6 RU https://clinicaltrials.gov/ct2/show/NCT03142646 DMHQ2U8 DI DMHQ2U8 DMHQ2U8 DN IMC-F106C DMHQ2U8 MI TTPH7T0 DMHQ2U8 MN Tumor expressed melanoma antigen (PRAME) DMHQ2U8 MT DTT DMHQ2U8 RN Clinical pipeline report, company report or official report of Immunocore. DMHQ2U8 RU https://www.immunocore.com/news/immunocore-announces-dosing-first-patient-fourth-immtac DM09JOZ DI DM09JOZ DM09JOZ DN ImMucin DM09JOZ MI TTBHFYQ DM09JOZ MN Mucin-1 (MUC1) DM09JOZ MT DTT DM09JOZ RN Phase I/II study exploring ImMucin, a pan-major histocompatibility complex, anti-MUC1 signal peptide vaccine, in multiple myeloma patients. Br J Haematol. 2015 Apr;169(1):44-56. DM09JOZ RU https://pubmed.ncbi.nlm.nih.gov/25496030 DM18ZLW DI DM18ZLW DM18ZLW DN IMP-321 DM18ZLW MI TTNVXAW DM18ZLW MN Lymphocyte activation gene 3 protein (LAG3) DM18ZLW MT DTT DM18ZLW MA Immunomodulator DM18ZLW RN A soluble form of lymphocyte activation gene-3 (IMP321) induces activation of a large range of human effector cytotoxic cells. J Immunol. 2007 Sep 15;179(6):4202-11. DM18ZLW RU https://pubmed.ncbi.nlm.nih.gov/17785860 DM43ICH DI DM43ICH DM43ICH DN IMSA101 DM43ICH MI TTT402Y DM43ICH MN Stimulator of interferon genes protein (TMEM173) DM43ICH MT DTT DM43ICH MA Agonist DM43ICH RN Clinical pipeline report, company report or official report of ImmuneSensor Therapeutics. DM43ICH RU http://www.immunesensor.com/ DMNHZS4 DI DMNHZS4 DMNHZS4 DN IMX-110 DMNHZS4 MI TTH8FZW DMNHZS4 MN Signal transducer and activator of transcription 3 (STAT3) DMNHZS4 MT DTT DMNHZS4 MA Inhibitor DMNHZS4 RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMNHZS4 RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DM8XN4A DI DM8XN4A DM8XN4A DN INCAGN1876 DM8XN4A MI TTG6LA7 DM8XN4A MN Activation-inducible TNFR family receptor (TNFRSF18) DM8XN4A MT DTT DM8XN4A MA Agonist DM8XN4A RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DM8XN4A RU http://phrma-docs.phrma.org/files/dmfile/MID_Immuno-Oncology-2017_Drug-List1.pdf DM7OE3X DI DM7OE3X DM7OE3X DN INCAGN1949 DM7OE3X MI TTL31H0 DM7OE3X MN OX40L receptor (CD134) DM7OE3X MT DTT DM7OE3X MA Agonist DM7OE3X RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DM7OE3X RU http://phrma-docs.phrma.org/files/dmfile/MID_Immuno-Oncology-2017_Drug-List1.pdf DM8124R DI DM8124R DM8124R DN INCB01158 DM8124R MI TTSANDR DM8124R MN Arginase (ARG) DM8124R MT DTT DM8124R MA Inhibitor DM8124R RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DM8124R RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DM7TZL0 DI DM7TZL0 DM7TZL0 DN INCB054329 DM7TZL0 MI TTE4BSY DM7TZL0 MN Bromodomain and extraterminal domain protein (BET) DM7TZL0 MT DTT DM7TZL0 MA Inhibitor DM7TZL0 RN The Novel Bromodomain and Extraterminal Domain Inhibitor INCB054329 Induces Vulnerabilities in Myeloma Cells That Inform Rational Combination Strategies. Clin Cancer Res. 2019 Jan 1;25(1):300-311. DM7TZL0 RU https://pubmed.ncbi.nlm.nih.gov/30206163 DMG65CV DI DMG65CV DMG65CV DN INCB057643 DMG65CV MI TTE4BSY DMG65CV MN Bromodomain and extraterminal domain protein (BET) DMG65CV MT DTT DMG65CV MA Inhibitor DMG65CV RN Development of 2 Bromodomain and Extraterminal Inhibitors With Distinct Pharmacokinetic and Pharmacodynamic Profiles for the Treatment of Advanced Malignancies. Clin Cancer Res. 2020 Mar 15;26(6):1247-1257. DMG65CV RU https://pubmed.ncbi.nlm.nih.gov/31527168 DMED9QV DI DMED9QV DMED9QV DN INCB40093 DMED9QV MI TTGBPJE DMED9QV MN PI3-kinase delta (PIK3CD) DMED9QV MT DTT DMED9QV MA Inhibitor DMED9QV RN INCB40093 is a selective PI3Kdelta inhibitor with potent antiproliferative activity against human B-cell tumors. DMED9QV RU http://cancerres.aacrjournals.org/content/74/19_Supplement/4531.short DMKMSP2 DI DMKMSP2 DMKMSP2 DN INCB53914 DMKMSP2 MI TTA7WGU DMKMSP2 MN Serine/threonine-protein kinase pim (PIM) DMKMSP2 MT DTT DMKMSP2 MA Inhibitor DMKMSP2 RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMKMSP2 RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DMBGU7V DI DMBGU7V DMBGU7V DN INCB57643 DMBGU7V MI TTRA6BO DMBGU7V MN Bromodomain-containing protein 4 (BRD4) DMBGU7V MT DTT DMBGU7V MA Inhibitor DMBGU7V RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMBGU7V RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DMRLV7G DI DMRLV7G DMRLV7G DN INCB59872 DMRLV7G MI TTNR0UQ DMRLV7G MN Lysine-specific histone demethylase 1 (LSD) DMRLV7G MT DTT DMRLV7G MA Inhibitor DMRLV7G RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMRLV7G RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DMQO5UF DI DMQO5UF DMQO5UF DN INCB62079 DMQO5UF MI TT5BR7T DMQO5UF MN Fibroblast growth factor receptor 4 (FGFR4) DMQO5UF MT DTT DMQO5UF MA Inhibitor DMQO5UF RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMQO5UF RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DMKNA94 DI DMKNA94 DMKNA94 DN INO-8875 DMKNA94 MI TTK25J1 DMKNA94 MN Adenosine A1 receptor (ADORA1) DMKNA94 MT DTT DMKNA94 MA Agonist DMKNA94 RN INO-8875, a highly selective A1 adenosine receptor agonist: evaluation of chronotropic, dromotropic, and hemodynamic effects in rats. J Pharmacol Exp Ther. 2013 Jan;344(1):59-67. DMKNA94 RU https://pubmed.ncbi.nlm.nih.gov/23055540 DMMZSIB DI DMMZSIB DMMZSIB DN Interferon alpha 5 DMMZSIB MI TTLHGSF DMMZSIB MN Interferon-alpha 5 (IFNA5) DMMZSIB MT DTT DMMZSIB MA Modulator DMMZSIB RN Interferons and viral infections. Biofactors. 2009 Jan-Feb;35(1):14-20. DMMZSIB RU https://pubmed.ncbi.nlm.nih.gov/19319841 DM9PJZT DI DM9PJZT DM9PJZT DN Ipamorelin DM9PJZT MI TTWDC17 DM9PJZT MN Growth hormone secretagogue receptor 1 (GHSR) DM9PJZT MT DTT DM9PJZT MA Modulator DM9PJZT RN Efficacy of ipamorelin, a novel ghrelin mimetic, in a rodent model of postoperative ileus.J Pharmacol Exp Ther.2009 Jun;329(3):1110-6. DM9PJZT RU https://www.ncbi.nlm.nih.gov/pubmed/19289567 DM8E3N6 DI DM8E3N6 DM8E3N6 DN IPP-204106 DM8E3N6 MI TTCSZH7 DM8E3N6 MN Nucleolin (NCL) DM8E3N6 MT DTT DM8E3N6 MA Modulator DM8E3N6 RN Company report (ImmuPharma) DM8E3N6 RU http://www.immupharma.org/cancer-treatment DM8E3N6 DI DM8E3N6 DM8E3N6 DN IPP-204106 DM8E3N6 MI TTHBS98 DM8E3N6 MN Nucleophosmin (NPM1) DM8E3N6 MT DTT DM8E3N6 MA Modulator DM8E3N6 RN Company report (ImmuPharma) DM8E3N6 RU http://www.immupharma.org/cancer-treatment DMQ5EYJ DI DMQ5EYJ DMQ5EYJ DN ISA-P53-01 DMQ5EYJ MI TT7SBF5 DMQ5EYJ MN Cellular tumor antigen p53 (TP53) DMQ5EYJ MT DTT DMQ5EYJ RN WO patent application no. 2013,1850,32, Nanotherapeutics for drug targeting. DMQ5EYJ RU http://worldwide.espacenet.com/publicationDetails/biblio?DB=worldwide.espacenet.com&II=0&ND=3&adjacent=true&locale=en_EP&FT=D&date=20131212&CC=WO&NR=2013185032A1&KC=A1 DM1WD8F DI DM1WD8F DM1WD8F DN ISB 1302 DM1WD8F MI TT6EO5L DM1WD8F MN Erbb2 tyrosine kinase receptor (HER2) DM1WD8F MT DTT DM1WD8F MA Inhibitor DM1WD8F RN Clinical pipeline report, company report or official report of Ichnos Sciences. DM1WD8F RU https://ichnossciences.com/wp-content/uploads/Ichnos-Sciences-Corporate-Deck-Sept-25-2020-FINAL.pdf DM1WD8F DI DM1WD8F DM1WD8F DN ISB 1302 DM1WD8F MI TTUN7MC DM1WD8F MN T-cell surface glycoprotein CD3 (CD3) DM1WD8F MT DTT DM1WD8F MA Inhibitor DM1WD8F RN Clinical pipeline report, company report or official report of Ichnos Sciences. DM1WD8F RU https://ichnossciences.com/wp-content/uploads/Ichnos-Sciences-Corporate-Deck-Sept-25-2020-FINAL.pdf DMG107N DI DMG107N DMG107N DN ISB 1342 DMG107N MI TTPURFN DMG107N MN Cyclic ADP-ribose hydrolase 1 (CD38) DMG107N MT DTT DMG107N MA Inhibitor DMG107N RN Clinical pipeline report, company report or official report of Ichnos Sciences. DMG107N RU https://ichnossciences.com/wp-content/uploads/Ichnos-Sciences-Corporate-Deck-Sept-25-2020-FINAL.pdf DMG107N DI DMG107N DMG107N DN ISB 1342 DMG107N MI TTUN7MC DMG107N MN T-cell surface glycoprotein CD3 (CD3) DMG107N MT DTT DMG107N MA Inhibitor DMG107N RN Clinical pipeline report, company report or official report of Ichnos Sciences. DMG107N RU https://ichnossciences.com/wp-content/uploads/Ichnos-Sciences-Corporate-Deck-Sept-25-2020-FINAL.pdf DMH32LC DI DMH32LC DMH32LC DN ISIS-DMPK DMH32LC MI TTZQTY2 DMH32LC MN DMPK messenger RNA (DMPK mRNA) DMH32LC MT DTT DMH32LC RN Clinical pipeline report, company report or official report of ISIS Pharmaceuticals. DMH32LC RU https://www.isispharm.com/pipeline/isis-dmpkrx/ DMDTNFB DI DMDTNFB DMDTNFB DN ISIS-STAT3 DMDTNFB MI TTHJT3X DMDTNFB MN STAT3 messenger RNA (STAT3 mRNA) DMDTNFB MT DTT DMDTNFB RN Clinical pipeline report, company report or official report of ISIS Pharmaceuticals (2011). DMDTNFB RU http://www.isispharm.com/index.htm DMA41DO DI DMA41DO DMA41DO DN Isunakinra DMA41DO MI TT5BFT0 DMA41DO MN Interleukin-1 receptor (IL1R) DMA41DO MT DTT DMA41DO MA Inhibitor DMA41DO RN Multicenter Study of a Novel Topical Interleukin-1 Receptor Inhibitor, Isunakinra, in Subjects With Moderate to Severe Dry Eye Disease. Eye Contact Lens. 2017 Sep;43(5):287-296. DMA41DO RU https://pubmed.ncbi.nlm.nih.gov/27466718 DM08TH3 DI DM08TH3 DM08TH3 DN ITI-214 DM08TH3 MI TTHQENC DM08TH3 MN Phosphodiesterase 1 (PDE1) DM08TH3 MT DTT DM08TH3 MA Inhibitor DM08TH3 RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DM08TH3 RU http://phrma-docs.phrma.org/files/dmfile/MID_Mental-Illness-2017-Drug-List_Final.pdf DM3KXMG DI DM3KXMG DM3KXMG DN IZONSTERIDE DM3KXMG MI TT2A0DR DM3KXMG MN Oxo-5-alpha-steroid 4-dehydrogenase (SRD5A) DM3KXMG MT DTT DM3KXMG MA Modulator DM3KXMG RN Phase I and clinical pharmacology of a type I and II, 5-alpha-reductase inhibitor (LY320236) in prostate cancer: elevation of estradiol as possible... Urology. 2004 Jan;63(1):114-9. DM3KXMG RU https://www.ncbi.nlm.nih.gov/pubmed/14751361 DMNMV0D DI DMNMV0D DMNMV0D DN JAB-3312 DMNMV0D MI TT7WUAV DMNMV0D MN Protein-tyrosine phosphatase SHP-2 (PTPN11) DMNMV0D MT DTT DMNMV0D MA Inhibitor DMNMV0D RN Clinical pipeline report, company report or official report of AbbVie. DMNMV0D RU https://www.abbvie.com/our-science/pipeline/jab-3068-jab-3312.html DMTMVEW DI DMTMVEW DMTMVEW DN JCAR014 DMTMVEW MI TTW640A DMTMVEW MN B-lymphocyte surface antigen B4 (CD19) DMTMVEW MT DTT DMTMVEW MA CAR-T-Cell-Therapy DMTMVEW RN ClinicalTrials.gov (NCT02706405) JCAR014 and Durvalumab in Treating Patients With Relapsed or Refractory B-cell Non-Hodgkin Lymphoma DMTMVEW RU https://clinicaltrials.gov/ct2/show/NCT02706405 DMJV2IF DI DMJV2IF DMJV2IF DN JCAR017 DMJV2IF MI TTW640A DMJV2IF MN B-lymphocyte surface antigen B4 (CD19) DMJV2IF MT DTT DMJV2IF MA CAR-T-Cell-Therapy DMJV2IF RN ClinicalTrials.gov (NCT03436771) Long-term Follow-up Study for Patients Previously Treated With a Juno CAR T-Cell Product DMJV2IF RU https://clinicaltrials.gov/ct2/show/NCT03436771 DM8P7FC DI DM8P7FC DM8P7FC DN JCARH125 DM8P7FC MI TTZ3P4W DM8P7FC MN B-cell maturation protein (TNFRSF17) DM8P7FC MT DTT DM8P7FC MA CAR-T-Cell-Therapy DM8P7FC RN ClinicalTrials.gov (NCT03436771) Long-term Follow-up Study for Patients Previously Treated With a Juno CAR T-Cell Product DM8P7FC RU https://clinicaltrials.gov/ct2/show/NCT03436771 DMD9X6U DI DMD9X6U DMD9X6U DN JNJ-68284528 DMD9X6U MI TTZ3P4W DMD9X6U MN B-cell maturation protein (TNFRSF17) DMD9X6U MT DTT DMD9X6U MA CAR-T-Cell-Therapy DMD9X6U RN ClinicalTrials.gov (NCT03548207) A Study of JNJ-68284528, a Chimeric Antigen Receptor T Cell (CAR-T) Therapy Directed Against B-Cell Maturation Antigen (BCMA) in Participants With Relapsed or Refractory Multiple Myeloma DMD9X6U RU https://clinicaltrials.gov/ct2/show/NCT03548207 DMGEZVF DI DMGEZVF DMGEZVF DN JS016 DMGEZVF MI TTZ3COY DMGEZVF MN COVID-19 spike glycoprotein (S) DMGEZVF MT DTT DMGEZVF MA Inhibitor DMGEZVF RN Clinical pipeline report, company report or official report of Lilly. DMGEZVF RU https://www.lilly.com/discovery/clinical-development-pipeline# DMELJDI DI DMELJDI DMELJDI DN KAI-9803 DMELJDI MI TT9WJ8U DMELJDI MN Protein kinase C delta (PRKCD) DMELJDI MT DTT DMELJDI MA Inhibitor DMELJDI RN PKC delta and epsilon in drug targeting and therapeutics. Recent Pat DNA Gene Seq. 2009;3(2):96-101. DMELJDI RU https://pubmed.ncbi.nlm.nih.gov/19519579 DM5U3IF DI DM5U3IF DM5U3IF DN KB-004 DM5U3IF MI TTHS2LR DM5U3IF MN Ephrin type-A receptor 3 (EPHA3) DM5U3IF MT DTT DM5U3IF RN Clinical pipeline report, company report or official report of Kalobios. DM5U3IF RU http://kalobios.com/kb004 DMI9FXE DI DMI9FXE DMI9FXE DN KBP-5074 DMI9FXE MI TT26PHO DMI9FXE MN Mineralocorticoid receptor (MR) DMI9FXE MT DTT DMI9FXE MA Antagonist DMI9FXE RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMI9FXE RU http://phrma-docs.phrma.org/files/dmfile/2018_Heart-Disease-and-Stroke_MID-Drug-List.pdf DMZ416B DI DMZ416B DMZ416B DN KD020 DMZ416B MI TTUS1RD DMZ416B MN Microsomal triglyceride transfer protein (MTTP) DMZ416B MT DTT DMZ416B MA Modulator DMZ416B RN Clinical pipeline report, company report or official report of Kadmon Pharmaceuticals. DMZ416B RU http://kadmon.com/press/kadmon-corporation-presents-encouraging-nonclinical-data-on-tesevatinib-kd019-at-aacr-annual-meeting/ DM0NZYC DI DM0NZYC DM0NZYC DN KO-539 DM0NZYC MI TT0CZBQ DM0NZYC MN Menin-MLL1 interaction (MEN1-KMT2A PPI) DM0NZYC MT DTT DM0NZYC MA Inhibitor DM0NZYC RN Clinical pipeline report, company report or official report of Kura Oncology. DM0NZYC RU https://kuraoncology.com/pipeline/#ko539 DML29RF DI DML29RF DML29RF DN KP-100 DML29RF MI TTWC6MY DML29RF MN Protein tyrosine phosphatase (PTP) DML29RF MT DTT DML29RF MA Inhibitor DML29RF RN Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800010512) DML29RF RU http://adisinsight.springer.com/drugs/800010512 DMA5B1S DI DMA5B1S DMA5B1S DN KRN-330 DMA5B1S MI TT96HUR DMA5B1S MN Cell surface A33 antigen (GPA33) DMA5B1S MT DTT DMA5B1S RN Phase 1/2 study of KRN330, a fully human anti-A33 monoclonal antibody, plus irinotecan as second-line treatment for patients with metastatic colorectal cancer. Invest New Drugs. 2014 Aug;32(4):682-90. DMA5B1S RU https://pubmed.ncbi.nlm.nih.gov/24691674 DME8JW1 DI DME8JW1 DME8JW1 DN KTE-C19 CAR DME8JW1 MI TTW640A DME8JW1 MN B-lymphocyte surface antigen B4 (CD19) DME8JW1 MT DTT DME8JW1 MA Inhibitor DME8JW1 RN Clinical pipeline report, company report or official report of Kite Pharma. DME8JW1 RU http://ir.kitepharma.com/releasedetail.cfm?releaseid=867609 DMXJ683 DI DMXJ683 DMXJ683 DN KY1044 DMXJ683 MI TTE5VP6 DMXJ683 MN Inducible T-cell costimulator (ICOS) DMXJ683 MT DTT DMXJ683 MA Inhibitor DMXJ683 RN Clinical pipeline report, company report or official report of Kymab. DMXJ683 RU https://www.kymab.com/pipeline/ky1044/ DMBEQ08 DI DMBEQ08 DMBEQ08 DN L-377202 DMBEQ08 MI TT0IHXV DMBEQ08 MN DNA topoisomerase II (TOP2) DMBEQ08 MT DTT DMBEQ08 MA Modulator DMBEQ08 RN Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41. DMBEQ08 RU https://www.ncbi.nlm.nih.gov/pubmed/15950434 DMFHV9L DI DMFHV9L DMFHV9L DN Leber's congenital amaurosis gene therapy DMFHV9L MI TTBOH16 DMFHV9L MN Retinal pigment epithelium protein (RPE65) DMFHV9L MT DTT DMFHV9L MA Modulator DMFHV9L RN ClinicalTrials.gov (NCT00749957) Phase 1/2 Safety and Efficacy Study of AAV-RPE65 Vector to Treat Leber Congenital Amaurosis. U.S. National Institutes of Health. DMFHV9L RU https://clinicaltrials.gov/ct2/show/NCT00749957 DMQN9ME DI DMQN9ME DMQN9ME DN LGH-447 DMQN9ME MI TT69J2Z DMQN9ME MN Serine/threonine-protein kinase pim-2 (PIM2) DMQN9ME MT DTT DMQN9ME MA Modulator DMQN9ME RN Pan-PIM kinase inhibition provides a novel therapy for treating hematologic cancers. Clin Cancer Res. 2014 Apr 1;20(7):1834-45. DMQN9ME RU https://pubmed.ncbi.nlm.nih.gov/24474669 DMENF5K DI DMENF5K DMENF5K DN Liatermin DMENF5K MI TTF23ML DMENF5K MN Glial cell line-derived neurotrophic factor (GDNF) DMENF5K MT DTT DMENF5K MA Modulator DMENF5K RN Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41. DMENF5K RU https://www.ncbi.nlm.nih.gov/pubmed/15950434 DMEMRW0 DI DMEMRW0 DMEMRW0 DN Lipoteichoic acid DMEMRW0 MI TTY7ZHS DMEMRW0 MN Toll-like receptor 2 (TLR2) DMEMRW0 MT DTT DMEMRW0 MA Modulator DMEMRW0 RN Lipoteichoic acid (LTA) of Streptococcus pneumoniae and Staphylococcus aureus activates immune cells via Toll-like receptor (TLR)-2, lipopolysaccha... J Biol Chem. 2003 May 2;278(18):15587-94. DMEMRW0 RU https://pubmed.ncbi.nlm.nih.gov/12594207 DMGTB5N DI DMGTB5N DMGTB5N DN LJM716 DMGTB5N MI TTDC8N2 DMGTB5N MN Erbb3 tyrosine kinase receptor (Erbb-3) DMGTB5N MT DTT DMGTB5N RN An antibody that locks HER3 in the inactive conformation inhibits tumor growth driven by HER2 or neuregulin. Cancer Res. 2013 Oct 1;73(19):6024-35. DMGTB5N RU https://pubmed.ncbi.nlm.nih.gov/23928993 DMCJ10K DI DMCJ10K DMCJ10K DN LM11A-31 DMCJ10K MI TTEDJN4 DMCJ10K MN Low-affinity nerve growth factor receptor (NGFR) DMCJ10K MT DTT DMCJ10K MA Modulator DMCJ10K RN Small molecule p75NTR ligand prevents cognitive deficits and neurite degeneration in an Alzheimer's mouse model.Neurobiol Aging.2013 Aug;34(8):2052-63. DMCJ10K RU https://www.ncbi.nlm.nih.gov/pubmed/23545424 DM095HQ DI DM095HQ DM095HQ DN LM11A-31 DM095HQ MI TTEDJN4 DM095HQ MN Low-affinity nerve growth factor receptor (NGFR) DM095HQ MT DTT DM095HQ MA Modulator DM095HQ RN Modulation of the p75 neurotrophin receptor using LM11A-31 prevents diabetes-induced retinal vascular permeability in mice via inhibition of inflammation and the RhoA kinase pathway. Diabetologia. 2019 Aug;62(8):1488-1500. DM095HQ RU https://pubmed.ncbi.nlm.nih.gov/31073629 DMW3QGJ DI DMW3QGJ DMW3QGJ DN LM-94 DMW3QGJ MI DEYGVN4 DMW3QGJ MN UDP-glucuronosyltransferase 1A1 (UGT1A1) DMW3QGJ MT DME DMW3QGJ MA Metabolism DMW3QGJ RN In vitro inhibitory effects of non-steroidal anti-inflammatory drugs on 4-methylumbelliferone glucuronidation in recombinant human UDP-glucuronosyltransferase 1A9--potent inhibition by niflumic acid. Biopharm Drug Dispos. 2006 Jan;27(1):1-6. DMW3QGJ RU https://www.ncbi.nlm.nih.gov/pubmed/?term=16278927 DMW3QGJ DI DMW3QGJ DMW3QGJ DN LM-94 DMW3QGJ MI DELOY3P DMW3QGJ MN UDP-glucuronosyltransferase 1A4 (UGT1A4) DMW3QGJ MT DME DMW3QGJ MA Metabolism DMW3QGJ RN Identification of aspartic acid and histidine residues mediating the reaction mechanism and the substrate specificity of the human UDP-glucuronosyltransferases 1A. J Biol Chem. 2007 Dec 14;282(50):36514-24. DMW3QGJ RU https://www.ncbi.nlm.nih.gov/pubmed/?term=17956868 DMW3QGJ DI DMW3QGJ DMW3QGJ DN LM-94 DMW3QGJ MI DEPF954 DMW3QGJ MN UDP-glucuronosyltransferase 1A5 (UGT1A5) DMW3QGJ MT DME DMW3QGJ MA Metabolism DMW3QGJ RN A common polymorphic variant of UGT1A5 displays increased activity due to optimized cofactor binding. FEBS Lett. 2018 Jun;592(11):1837-1846. DMW3QGJ RU https://pubmed.ncbi.nlm.nih.gov/29710432 DMW3QGJ DI DMW3QGJ DMW3QGJ DN LM-94 DMW3QGJ MI DESD26P DMW3QGJ MN UDP-glucuronosyltransferase 1A6 (UGT1A6) DMW3QGJ MT DME DMW3QGJ MA Metabolism DMW3QGJ RN Identification of aspartic acid and histidine residues mediating the reaction mechanism and the substrate specificity of the human UDP-glucuronosyltransferases 1A. J Biol Chem. 2007 Dec 14;282(50):36514-24. DMW3QGJ RU https://www.ncbi.nlm.nih.gov/pubmed/?term=17956868 DMW3QGJ DI DMW3QGJ DMW3QGJ DN LM-94 DMW3QGJ MI DE85D2P DMW3QGJ MN UDP-glucuronosyltransferase 1A9 (UGT1A9) DMW3QGJ MT DME DMW3QGJ MA Metabolism DMW3QGJ RN The "albumin effect" and drug glucuronidation: bovine serum albumin and fatty acid-free human serum albumin enhance the glucuronidation of UDP-glucuronosyltransferase (UGT) 1A9 substrates but not UGT1A1 and UGT1A6 activities. Drug Metab Dispos. 2008 Jun;36(6):1056-62. DMW3QGJ RU https://www.ncbi.nlm.nih.gov/pubmed/?term=18362158 DMW3QGJ DI DMW3QGJ DMW3QGJ DN LM-94 DMW3QGJ MI DE7TIN4 DMW3QGJ MN UDP-glucuronosyltransferase 2B11 (UGT2B11) DMW3QGJ MT DME DMW3QGJ MA Metabolism DMW3QGJ RN cDNA cloning and expression of two new members of the human liver UDP-glucuronosyltransferase 2B subfamily. Biochem Biophys Res Commun. 1993 Jul 15;194(1):496-503. DMW3QGJ RU https://pubmed.ncbi.nlm.nih.gov/8333863 DMYGNDI DI DMYGNDI DMYGNDI DN LMP1-CAR-T cells DMYGNDI MI TT0BI4Q DMYGNDI MN Epstein-Barr virus Latent membrane protein 1 (EBV LMP1) DMYGNDI MT DTT DMYGNDI MA CAR-T-Cell-Therapy DMYGNDI RN ClinicalTrials.gov (NCT02980315) A New EBV Related Technologies of T Cells in Treating Malignant Tumors and Clinical Application DMYGNDI RU https://clinicaltrials.gov/ct2/show/NCT02980315 DMZNIAG DI DMZNIAG DMZNIAG DN LS-172108 DMZNIAG MI DE4LYSA DMZNIAG MN Cytochrome P450 3A4 (CYP3A4) DMZNIAG MT DME DMZNIAG MA Metabolism DMZNIAG RN Biotransformation of tirilazad in human: 1. Cytochrome P450 3A-mediated hydroxylation of tirilazad mesylate in human liver microsomes. J Pharmacol Exp Ther. 1996 May;277(2):982-90. DMZNIAG RU https://www.ncbi.nlm.nih.gov/pubmed/?term=8627581 DM5N04G DI DM5N04G DM5N04G DN LT-1951 DM5N04G MI TTF10I9 DM5N04G MN Nitric-oxide synthase inducible (NOS2) DM5N04G MT DTT DM5N04G MA Modulator DM5N04G RN Critical role of L-arginine in endothelial cell survival during oxidative stress. Circulation. 2003 May 27;107(20):2607-14. DM5N04G RU https://pubmed.ncbi.nlm.nih.gov/12742995 DM2LYIN DI DM2LYIN DM2LYIN DN LX-7101 DM2LYIN MI TTU8W4S DM2LYIN MN Protein kinase (PK) DM2LYIN MT DTT DM2LYIN MA Inhibitor DM2LYIN RN Design, synthesis and biological characterization of selective LIMK inhibitors. Bioorg Med Chem Lett. 2015 Sep 15;25(18):4005-10. DM2LYIN RU https://pubmed.ncbi.nlm.nih.gov/26233434 DM65MEL DI DM65MEL DM65MEL DN LXS196 DM65MEL MI TTYVX59 DM65MEL MN Protein kinase C (PRKC) DM65MEL MT DTT DM65MEL MA Inhibitor DM65MEL RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DM65MEL RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DMHXTNW DI DMHXTNW DMHXTNW DN LY-2228820 DMHXTNW MI TTWELHI DMHXTNW MN Stress-activated protein kinase (p38) DMHXTNW MT DTT DMHXTNW MA Inhibitor DMHXTNW RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7959). DMHXTNW RU http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=7959 DMADEHZ DI DMADEHZ DMADEHZ DN LY2880070 DMADEHZ MI TTTU902 DMADEHZ MN Checkpoint kinase-1 (CHK1) DMADEHZ MT DTT DMADEHZ MA Inhibitor DMADEHZ RN A phase Ib study of oral Chk1 inhibitor LY2880070 in combination with gemcitabine in patients with advanced or metastatic cancer. Journal of Clinical Oncology 38, no. 15_suppl (May 20, 2020) 3581-3581. DMADEHZ RU https://ascopubs.org/doi/abs/10.1200/JCO.2020.38.15_suppl.3581 DMTJWIQ DI DMTJWIQ DMTJWIQ DN LY2940680 DMTJWIQ MI DE4LYSA DMTJWIQ MN Cytochrome P450 3A4 (CYP3A4) DMTJWIQ MT DME DMTJWIQ MA Metabolism DMTJWIQ RN Phase I study of LY2940680, a Smo antagonist, in patients with advanced cancer including treatment-naive and previously treated basal cell carcinoma. Clin Cancer Res. 2018 May 1;24(9):2082-2091. DMTJWIQ RU https://www.ncbi.nlm.nih.gov/pubmed/?term=29483143 DMTJWIQ DI DMTJWIQ DMTJWIQ DN LY2940680 DMTJWIQ MI TT8J1S3 DMTJWIQ MN Smoothened homolog (SMO) DMTJWIQ MT DTT DMTJWIQ MA Modulator DMTJWIQ RN Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41. DMTJWIQ RU https://www.ncbi.nlm.nih.gov/pubmed/15950434 DM7T1CR DI DM7T1CR DM7T1CR DN LY3016859 DM7T1CR MI TTYSB89 DM7T1CR MN Epiregulin (EREG) DM7T1CR MT DTT DM7T1CR MA Modulator DM7T1CR RN Generation and activity of a humanized monoclonal antibody that selectively neutralizes the epidermal growth factor receptor ligands transforming growth factor-alpha and epiregulin. J Pharmacol Exp Ther. 2014 May;349(2):330-43. DM7T1CR RU https://pubmed.ncbi.nlm.nih.gov/24518034 DM7T1CR DI DM7T1CR DM7T1CR DN LY3016859 DM7T1CR MI TTTLQFR DM7T1CR MN Transforming growth factor alpha (TGFA) DM7T1CR MT DTT DM7T1CR MA Modulator DM7T1CR RN Generation and activity of a humanized monoclonal antibody that selectively neutralizes the epidermal growth factor receptor ligands transforming growth factor-alpha and epiregulin. J Pharmacol Exp Ther. 2014 May;349(2):330-43. DM7T1CR RU https://pubmed.ncbi.nlm.nih.gov/24518034 DMC5SAW DI DMC5SAW DMC5SAW DN LY3039478 DMC5SAW MI TTB1STW DMC5SAW MN Notch-1 receptor (NOTCH1) DMC5SAW MT DTT DMC5SAW MA Inhibitor DMC5SAW RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMC5SAW RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DMC5SAW DI DMC5SAW DMC5SAW DN LY3039478 DMC5SAW MI TTXDIK2 DMC5SAW MN Notch-4 receptor (NOTCH4) DMC5SAW MT DTT DMC5SAW MA Inhibitor DMC5SAW RN J Clin Oncol 33, 2015 (suppl; abstr 2533). DMC5SAW RU http://meetinglibrary.asco.org/content/144588-156 DM8RJTB DI DM8RJTB DM8RJTB DN LY3295668 DM8RJTB MI TTPS3C0 DM8RJTB MN Aurora kinase A (AURKA) DM8RJTB MT DTT DM8RJTB MA Inhibitor DM8RJTB RN Aurora A-Selective Inhibitor LY3295668 Leads to Dominant Mitotic Arrest, Apoptosis in Cancer Cells, and Shows Potent Preclinical Antitumor Efficacy. Mol Cancer Ther. 2019 Dec;18(12):2207-2219. DM8RJTB RU https://pubmed.ncbi.nlm.nih.gov/31530649 DMA1CSR DI DMA1CSR DMA1CSR DN LY3499446 DMA1CSR MI TT3LH46 DMA1CSR MN KRAS G12C mutant (KRAS G12C) DMA1CSR MT DTT DMA1CSR MA Inhibitor DMA1CSR RN KRAS: From undruggable to a druggable Cancer Target. Cancer Treat Rev. 2020 Sep;89:102070. DMA1CSR RU https://pubmed.ncbi.nlm.nih.gov/32711246 DMK2L38 DI DMK2L38 DMK2L38 DN M3814 DMK2L38 MI TTK3PY9 DMK2L38 MN DNA-dependent protein kinase catalytic (PRKDC) DMK2L38 MT DTT DMK2L38 MA Inhibitor DMK2L38 RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMK2L38 RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DMIRG15 DI DMIRG15 DMIRG15 DN MaC46/M87o DMIRG15 MI TTG90S6 DMIRG15 MN Human immunodeficiency virus Glycoprotein 41 (HIV gp41) DMIRG15 MT DTT DMIRG15 MA Modulator DMIRG15 RN DOI: 10.1038/mt.sj.6300124 DMIRG15 RU http://www.nature.com/mt/journal/v15/n5/full/6300124a.html DM6H3YS DI DM6H3YS DM6H3YS DN MAGE-A10 TCR DM6H3YS MI TT7AKW1 DM6H3YS MN T-cell receptor (TCR) DM6H3YS MT DTT DM6H3YS MA Immunomodulator DM6H3YS RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DM6H3YS RU http://phrma-docs.phrma.org/files/dmfile/MID_Immuno-Oncology-2017_Drug-List1.pdf DMFK5IX DI DMFK5IX DMFK5IX DN MAK683 DMFK5IX MI TTFNJ4R DMFK5IX MN Embryonic ectoderm development protein (EED) DMFK5IX MT DTT DMFK5IX MA Inhibitor DMFK5IX RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMFK5IX RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DMBZ68C DI DMBZ68C DMBZ68C DN MALP-2S DMBZ68C MI TTY7ZHS DMBZ68C MN Toll-like receptor 2 (TLR2) DMBZ68C MT DTT DMBZ68C MA Modulator DMBZ68C RN Failure of mycoplasma lipoprotein MALP-2 to induce NK cell activation through dendritic cell TLR2. Microbes Infect. 2011 Apr;13(4):350-8. DMBZ68C RU https://pubmed.ncbi.nlm.nih.gov/21172450 DMBZ68C DI DMBZ68C DMBZ68C DN MALP-2S DMBZ68C MI TTWRI8V DMBZ68C MN Toll-like receptor 6 (TLR6) DMBZ68C MT DTT DMBZ68C MA Modulator DMBZ68C RN Failure of mycoplasma lipoprotein MALP-2 to induce NK cell activation through dendritic cell TLR2. Microbes Infect. 2011 Apr;13(4):350-8. DMBZ68C RU https://pubmed.ncbi.nlm.nih.gov/21172450 DMH0ROP DI DMH0ROP DMH0ROP DN Maltose DMH0ROP MI DEST6E5 DMH0ROP MN Alpha-glucosidase (aglA) DMH0ROP MT DME DMH0ROP MA Metabolism DMH0ROP RN Novel alpha-glucosidase from human gut microbiome: substrate specificities and their switch. FASEB J. 2010 Oct;24(10):3939-49. DMH0ROP RU https://pubmed.ncbi.nlm.nih.gov/20581222 DMH0ROP DI DMH0ROP DMH0ROP DN Maltose DMH0ROP MI TTHCF4J DMH0ROP MN Alpha-glucosidase (GLA) DMH0ROP MT DTT DMH0ROP MA Inhibitor DMH0ROP RN DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Nucleic Acids Res. 2011 Jan;39(Database issue):D1035-41. DMH0ROP RU https://pubmed.ncbi.nlm.nih.gov/21059682 DMH0ROP DI DMH0ROP DMH0ROP DN Maltose DMH0ROP MI DEGLW18 DMH0ROP MN Cellobiose 2-epimerase (CE) DMH0ROP MT DME DMH0ROP MA Metabolism DMH0ROP RN Cloning and sequencing of the gene for cellobiose 2-epimerase from a ruminal strain of Eubacterium cellulosolvens. FEMS Microbiol Lett. 2008 Oct;287(1):34-40. DMH0ROP RU https://pubmed.ncbi.nlm.nih.gov/18710396 DMH0ROP DI DMH0ROP DMH0ROP DN Maltose DMH0ROP MI DENTGJO DMH0ROP MN Cellobiose 2-epimerase (CE) DMH0ROP MT DME DMH0ROP MA Metabolism DMH0ROP RN Cloning and sequencing of the gene for cellobiose 2-epimerase from a ruminal strain of Eubacterium cellulosolvens. FEMS Microbiol Lett. 2008 Oct;287(1):34-40. DMH0ROP RU https://pubmed.ncbi.nlm.nih.gov/18710396 DMH0ROP DI DMH0ROP DMH0ROP DN Maltose DMH0ROP MI DE4XLDR DMH0ROP MN Cellobiose 2-epimerase (CE) DMH0ROP MT DME DMH0ROP MA Metabolism DMH0ROP RN Cloning and sequencing of the gene for cellobiose 2-epimerase from a ruminal strain of Eubacterium cellulosolvens. FEMS Microbiol Lett. 2008 Oct;287(1):34-40. DMH0ROP RU https://pubmed.ncbi.nlm.nih.gov/18710396 DMH0ROP DI DMH0ROP DMH0ROP DN Maltose DMH0ROP MI DEGBVKJ DMH0ROP MN Cellobiose 2-epimerase (CE) DMH0ROP MT DME DMH0ROP MA Metabolism DMH0ROP RN Cloning and sequencing of the gene for cellobiose 2-epimerase from a ruminal strain of Eubacterium cellulosolvens. FEMS Microbiol Lett. 2008 Oct;287(1):34-40. DMH0ROP RU https://pubmed.ncbi.nlm.nih.gov/18710396 DMH0ROP DI DMH0ROP DMH0ROP DN Maltose DMH0ROP MI DEDY9F6 DMH0ROP MN Cellobiose 2-epimerase (CE) DMH0ROP MT DME DMH0ROP MA Metabolism DMH0ROP RN Cloning and sequencing of the gene for cellobiose 2-epimerase from a ruminal strain of Eubacterium cellulosolvens. FEMS Microbiol Lett. 2008 Oct;287(1):34-40. DMH0ROP RU https://pubmed.ncbi.nlm.nih.gov/18710396 DMH0ROP DI DMH0ROP DMH0ROP DN Maltose DMH0ROP MI DERDXAF DMH0ROP MN Cellobiose 2-epimerase (CE) DMH0ROP MT DME DMH0ROP MA Metabolism DMH0ROP RN Cloning and sequencing of the gene for cellobiose 2-epimerase from a ruminal strain of Eubacterium cellulosolvens. FEMS Microbiol Lett. 2008 Oct;287(1):34-40. DMH0ROP RU https://pubmed.ncbi.nlm.nih.gov/18710396 DMH0ROP DI DMH0ROP DMH0ROP DN Maltose DMH0ROP MI DEBW1FU DMH0ROP MN Fructokinase (scrK) DMH0ROP MT DME DMH0ROP MA Metabolism DMH0ROP RN Sugar metabolism by fusobacteria: regulation of transport, phosphorylation, and polymer formation by Fusobacterium mortiferum ATCC 25557. Infect Immun. 1991 Dec;59(12):4547-54. DMH0ROP RU https://pubmed.ncbi.nlm.nih.gov/1937813 DMH0ROP DI DMH0ROP DMH0ROP DN Maltose DMH0ROP MI TTXWASR DMH0ROP MN Intestinal maltase-glucoamylase (MGAM) DMH0ROP MT DTT DMH0ROP MA Inhibitor DMH0ROP RN DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Nucleic Acids Res. 2011 Jan;39(Database issue):D1035-41. DMH0ROP RU https://pubmed.ncbi.nlm.nih.gov/21059682 DMH0ROP DI DMH0ROP DMH0ROP DN Maltose DMH0ROP MI DE7NXHG DMH0ROP MN Maltose phosphorylase (malP) DMH0ROP MT DME DMH0ROP MA Metabolism DMH0ROP RN Rational engineering of Lactobacillus acidophilus NCFM maltose phosphorylase into either trehalose or kojibiose dual specificity phosphorylase. Protein Eng Des Sel. 2010 Oct;23(10):781-7. DMH0ROP RU https://pubmed.ncbi.nlm.nih.gov/20713411 DMH0ROP DI DMH0ROP DMH0ROP DN Maltose DMH0ROP MI DE5EO4Y DMH0ROP MN Sucrase-isomaltase intestinal (SI) DMH0ROP MT DME DMH0ROP MA Metabolism DMH0ROP RN Structural basis for substrate selectivity in human maltase-glucoamylase and sucrase-isomaltase N-terminal domains. J Biol Chem. 2010 Jun 4;285(23):17763-70. DMH0ROP RU https://www.ncbi.nlm.nih.gov/pubmed/?term=20356844 DMXU7P6 DI DMXU7P6 DMXU7P6 DN MB-CART20.1 DMXU7P6 MI TTUE541 DMXU7P6 MN Leukocyte surface antigen Leu-16 (CD20) DMXU7P6 MT DTT DMXU7P6 MA CAR-T-Cell-Therapy DMXU7P6 RN ClinicalTrials.gov (NCT03664635) MB-CART20.1 Lymphoma DMXU7P6 RU https://clinicaltrials.gov/ct2/show/NCT03664635 DMS19IH DI DMS19IH DMS19IH DN MBO7133 DMS19IH MI TTUTN1I DMS19IH MN Human Deoxyribonucleic acid (hDNA) DMS19IH MT DTT DMS19IH MA Binder DMS19IH RN Novel Cox-2 Inhibitor for Breast Cancer Therapy. Temple University School of Medicine Philadelphia, Pennsylvania 19140. July 2004. DMS19IH RU http://www.dtic.mil/get-tr-doc/pdf?AD=ADA431390 DMTCADJ DI DMTCADJ DMTCADJ DN McN3377 DMTCADJ MI TTHS256 DMTCADJ MN Metabotropic glutamate receptor 5 (mGluR5) DMTCADJ MT DTT DMTCADJ MA Modulator DMTCADJ RN Glutamate- and GABA-based CNS therapeutics. Curr Opin Pharmacol. 2006 Feb;6(1):7-17. DMTCADJ RU https://pubmed.ncbi.nlm.nih.gov/16377242 DM6JN19 DI DM6JN19 DM6JN19 DN ME-344 DM6JN19 MI TTX4GLS DM6JN19 MN Mammalian target of rapamycin complex 1 (mTORC1) DM6JN19 MT DTT DM6JN19 MA Inhibitor DM6JN19 RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DM6JN19 RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DM6JN19 DI DM6JN19 DM6JN19 DN ME-344 DM6JN19 MI TTCJG29 DM6JN19 MN Serine/threonine-protein kinase mTOR (mTOR) DM6JN19 MT DTT DM6JN19 MA Inhibitor DM6JN19 RN National Cancer Institute Drug Dictionary (drug id 728650). DM6JN19 RU http://www.cancer.gov/publications/dictionaries/cancer-drug?cdrid=728650 DM6JN19 DI DM6JN19 DM6JN19 DN ME-344 DM6JN19 MI TTWDKCL DM6JN19 MN Target of rapamycin complex 2 MAPKAP1 (MTORC2) DM6JN19 MT DTT DM6JN19 MA Inhibitor DM6JN19 RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DM6JN19 RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DMMB5CV DI DMMB5CV DMMB5CV DN Medusa IL-2 DMMB5CV MI TTF89GD DMMB5CV MN Interleukin-2 (IL2) DMMB5CV MT DTT DMMB5CV MA Modulator DMMB5CV RN Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41. DMMB5CV RU https://www.ncbi.nlm.nih.gov/pubmed/15950434 DMJVFK7 DI DMJVFK7 DMJVFK7 DN Meplazumab DMJVFK7 MI TTG21IS DMJVFK7 MN HUMAN basigin (BSG) DMJVFK7 MT DTT DMJVFK7 MA Inhibitor DMJVFK7 RN Meplazumab treats COVID-19 pneumonia: an open-labelled, concurrent controlled add-on clinical trial DMJVFK7 RU https://www.medrxiv.org/content/10.1101/2020.03.21.20040691v1 DMENFD6 DI DMENFD6 DMENFD6 DN Metelimumab DMENFD6 MI TTP4520 DMENFD6 MN TGF-beta receptor type I (TGFBR1) DMENFD6 MT DTT DMENFD6 RN Development of TGF-beta signalling inhibitors for cancer therapy. Nat Rev Drug Discov. 2004 Dec;3(12):1011-22. DMENFD6 RU https://pubmed.ncbi.nlm.nih.gov/15573100 DME6PB0 DI DME6PB0 DME6PB0 DN MG7-CART DME6PB0 MI TTPW9LJ DME6PB0 MN Co-stimulatory molecule 4-1BB (CD137) DME6PB0 MT DTT DME6PB0 MA CAR-T-Cell-Therapy DME6PB0 RN ClinicalTrials.gov (NCT02862704) A Study of MG7 Redirected Autologous T Cells for Advanced MG7 Positive Liver Metastases(MG7-CART) DME6PB0 RU https://clinicaltrials.gov/ct2/show/NCT02862704 DME6PB0 DI DME6PB0 DME6PB0 DN MG7-CART DME6PB0 MI TTPXOQN DME6PB0 MN Gastric carcinoma-associated antigen MG7 (MG7) DME6PB0 MT DTT DME6PB0 MA CAR-T-Cell-Therapy DME6PB0 RN ClinicalTrials.gov (NCT02862704) A Study of MG7 Redirected Autologous T Cells for Advanced MG7 Positive Liver Metastases(MG7-CART) DME6PB0 RU https://clinicaltrials.gov/ct2/show/NCT02862704 DM1KZW0 DI DM1KZW0 DM1KZW0 DN MGC018 DM1KZW0 MI TT6CQUM DM1KZW0 MN B7 homolog 3 (CD276) DM1KZW0 MT DTT DM1KZW0 RN Clinical pipeline report, company report or official report of MacroGenics. DM1KZW0 RU https://www.macrogenics.com/mgc018-b7-h3/ DMAHWLR DI DMAHWLR DMAHWLR DN MGD007 DMAHWLR MI TT96HUR DMAHWLR MN Cell surface A33 antigen (GPA33) DMAHWLR MT DTT DMAHWLR MA Modulator DMAHWLR RN Bispecific antibodies rise again. Nat Rev Drug Discov. 2014 Nov;13(11):799-801. DMAHWLR RU https://www.ncbi.nlm.nih.gov/pubmed/25359367 DMAHWLR DI DMAHWLR DMAHWLR DN MGD007 DMAHWLR MI TTV3XPL DMAHWLR MN T-cell surface glycoprotein CD3 gamma (CD3G) DMAHWLR MT DTT DMAHWLR MA Modulator DMAHWLR RN Bispecific antibodies rise again. Nat Rev Drug Discov. 2014 Nov;13(11):799-801. DMAHWLR RU https://www.ncbi.nlm.nih.gov/pubmed/25359367 DMCVMUL DI DMCVMUL DMCVMUL DN MGD013 DMCVMUL MI TTNBFWK DMCVMUL MN Programmed cell death protein 1 (PD-1) DMCVMUL MT DTT DMCVMUL RN Development of Inhibitors of the Programmed Cell Death-1/Programmed Cell Death-Ligand 1 Signaling Pathway.J Med Chem. 2019 Feb 28;62(4):1715-1730. DMCVMUL RU https://pubmed.ncbi.nlm.nih.gov/30247903 DM4H7UY DI DM4H7UY DM4H7UY DN Milatuzumab DM4H7UY MI TTCMYP9 DM4H7UY MN HLA-DR antigens-associated invariant (CD74) DM4H7UY MT DTT DM4H7UY RN Combination anti-CD74 (milatuzumab) and anti-CD20 (rituximab) monoclonal antibody therapy has in vitro and in vivo activity in mantle cell lymphoma. Blood. 2011 Apr 28;117(17):4530-41. DM4H7UY RU https://pubmed.ncbi.nlm.nih.gov/21228331 DM25QKC DI DM25QKC DM25QKC DN MK-1308 DM25QKC MI TTI2S1D DM25QKC MN Cytotoxic T-lymphocyte protein 4 (CTLA-4) DM25QKC MT DTT DM25QKC MA Inhibitor DM25QKC RN Safety and efficacy of quavonlimab, a novel anti-CTLA-4 antibody (MK-1308), in combination with pembrolizumab in first-line advanced non-small-cell lung cancer. Ann Oncol. 2021 Mar;32(3):395-403. DM25QKC RU https://pubmed.ncbi.nlm.nih.gov/33276076 DM21WBH DI DM21WBH DM21WBH DN MK-2461 DM21WBH MI TTKN7QR DM21WBH MN BDNF/NT-3 growth factors receptor (TrkB) DM21WBH MT DTT DM21WBH MA Inhibitor DM21WBH RN MK-2461, a novel multitargeted kinase inhibitor, preferentially inhibits the activated c-Met receptor. Cancer Res. 2010 Feb 15;70(4):1524-33. DM21WBH RU https://pubmed.ncbi.nlm.nih.gov/20145145 DM21WBH DI DM21WBH DM21WBH DN MK-2461 DM21WBH MI TTRLW2X DM21WBH MN Fibroblast growth factor receptor 1 (FGFR1) DM21WBH MT DTT DM21WBH MA Inhibitor DM21WBH RN MK-2461, a novel multitargeted kinase inhibitor, preferentially inhibits the activated c-Met receptor. Cancer Res. 2010 Feb 15;70(4):1524-33. DM21WBH RU https://pubmed.ncbi.nlm.nih.gov/20145145 DM21WBH DI DM21WBH DM21WBH DN MK-2461 DM21WBH MI TTGJVQM DM21WBH MN Fibroblast growth factor receptor 2 (FGFR2) DM21WBH MT DTT DM21WBH MA Inhibitor DM21WBH RN MK-2461, a novel multitargeted kinase inhibitor, preferentially inhibits the activated c-Met receptor. Cancer Res. 2010 Feb 15;70(4):1524-33. DM21WBH RU https://pubmed.ncbi.nlm.nih.gov/20145145 DM21WBH DI DM21WBH DM21WBH DN MK-2461 DM21WBH MI TTST7KB DM21WBH MN Fibroblast growth factor receptor 3 (FGFR3) DM21WBH MT DTT DM21WBH MA Inhibitor DM21WBH RN MK-2461, a novel multitargeted kinase inhibitor, preferentially inhibits the activated c-Met receptor. Cancer Res. 2010 Feb 15;70(4):1524-33. DM21WBH RU https://pubmed.ncbi.nlm.nih.gov/20145145 DM21WBH DI DM21WBH DM21WBH DN MK-2461 DM21WBH MI TTGJCWZ DM21WBH MN Fms-like tyrosine kinase 3 (FLT-3) DM21WBH MT DTT DM21WBH MA Inhibitor DM21WBH RN MK-2461, a novel multitargeted kinase inhibitor, preferentially inhibits the activated c-Met receptor. Cancer Res. 2010 Feb 15;70(4):1524-33. DM21WBH RU https://pubmed.ncbi.nlm.nih.gov/20145145 DM21WBH DI DM21WBH DM21WBH DN MK-2461 DM21WBH MI TTBQ3OC DM21WBH MN Macrophage-stimulating protein receptor (RON) DM21WBH MT DTT DM21WBH MA Inhibitor DM21WBH RN MK-2461, a novel multitargeted kinase inhibitor, preferentially inhibits the activated c-Met receptor. Cancer Res. 2010 Feb 15;70(4):1524-33. DM21WBH RU https://pubmed.ncbi.nlm.nih.gov/20145145 DM21WBH DI DM21WBH DM21WBH DN MK-2461 DM21WBH MI TTXABCW DM21WBH MN NT-3 growth factor receptor (TrkC) DM21WBH MT DTT DM21WBH MA Inhibitor DM21WBH RN MK-2461, a novel multitargeted kinase inhibitor, preferentially inhibits the activated c-Met receptor. Cancer Res. 2010 Feb 15;70(4):1524-33. DM21WBH RU https://pubmed.ncbi.nlm.nih.gov/20145145 DM21WBH DI DM21WBH DM21WBH DN MK-2461 DM21WBH MI TTI7421 DM21WBH MN Platelet-derived growth factor receptor beta (PDGFRB) DM21WBH MT DTT DM21WBH MA Inhibitor DM21WBH RN MK-2461, a novel multitargeted kinase inhibitor, preferentially inhibits the activated c-Met receptor. Cancer Res. 2010 Feb 15;70(4):1524-33. DM21WBH RU https://pubmed.ncbi.nlm.nih.gov/20145145 DM21WBH DI DM21WBH DM21WBH DN MK-2461 DM21WBH MI TTNDSF4 DM21WBH MN Proto-oncogene c-Met (MET) DM21WBH MT DTT DM21WBH MA Inhibitor DM21WBH RN MK-2461, a novel multitargeted kinase inhibitor, preferentially inhibits the activated c-Met receptor. Cancer Res. 2010 Feb 15;70(4):1524-33. DM21WBH RU https://pubmed.ncbi.nlm.nih.gov/20145145 DM21WBH DI DM21WBH DM21WBH DN MK-2461 DM21WBH MI TTO7LKR DM21WBH MN Tyrosine-protein kinase Mer (MERTK) DM21WBH MT DTT DM21WBH MA Inhibitor DM21WBH RN MK-2461, a novel multitargeted kinase inhibitor, preferentially inhibits the activated c-Met receptor. Cancer Res. 2010 Feb 15;70(4):1524-33. DM21WBH RU https://pubmed.ncbi.nlm.nih.gov/20145145 DM21WBH DI DM21WBH DM21WBH DN MK-2461 DM21WBH MI TTUTJGQ DM21WBH MN Vascular endothelial growth factor receptor 2 (KDR) DM21WBH MT DTT DM21WBH MA Inhibitor DM21WBH RN MK-2461, a novel multitargeted kinase inhibitor, preferentially inhibits the activated c-Met receptor. Cancer Res. 2010 Feb 15;70(4):1524-33. DM21WBH RU https://pubmed.ncbi.nlm.nih.gov/20145145 DM21WBH DI DM21WBH DM21WBH DN MK-2461 DM21WBH MI TTDCBX5 DM21WBH MN Vascular endothelial growth factor receptor 3 (FLT-4) DM21WBH MT DTT DM21WBH MA Inhibitor DM21WBH RN MK-2461, a novel multitargeted kinase inhibitor, preferentially inhibits the activated c-Met receptor. Cancer Res. 2010 Feb 15;70(4):1524-33. DM21WBH RU https://pubmed.ncbi.nlm.nih.gov/20145145 DM21WBH DI DM21WBH DM21WBH DN MK-2461 DM21WBH MI TT1VAUK DM21WBH MN VEGFR1 messenger RNA (VEGFR1 mRNA) DM21WBH MT DTT DM21WBH MA Inhibitor DM21WBH RN MK-2461, a novel multitargeted kinase inhibitor, preferentially inhibits the activated c-Met receptor. Cancer Res. 2010 Feb 15;70(4):1524-33. DM21WBH RU https://pubmed.ncbi.nlm.nih.gov/20145145 DMCVBQD DI DMCVBQD DMCVBQD DN MLN1117 DMCVBQD MI TTEUNMR DMCVBQD MN PI3-kinase alpha (PIK3CA) DMCVBQD MT DTT DMCVBQD MA Inhibitor DMCVBQD RN National Cancer Institute Drug Dictionary (drug id 714372). DMCVBQD RU http://www.cancer.gov/publications/dictionaries/cancer-drug?cdrid=714372 DMGC96P DI DMGC96P DMGC96P DN MLN-2704 DMGC96P MI TT9G4N0 DMGC96P MN Glutamate carboxypeptidase II (GCPII) DMGC96P MT DTT DMGC96P RN Phase I trial of the prostate-specific membrane antigen-directed immunoconjugate MLN2704 in patients with progressive metastatic castration-resistant prostate cancer. J Clin Oncol. 2008 May 1;26(13):2147-54. DMGC96P RU https://pubmed.ncbi.nlm.nih.gov/18362364 DMG7XHE DI DMG7XHE DMG7XHE DN Monalizumab DMG7XHE MI TTC4IMS DMG7XHE MN NKG2-A/B-activating NK receptor (NKG2A) DMG7XHE MT DTT DMG7XHE MA Antagonist DMG7XHE RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMG7XHE RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DMXVIQN DI DMXVIQN DMXVIQN DN MOR-103 DMXVIQN MI TT6MP2Z DMXVIQN MN GMCSFR-alpha (CSF2RA) DMXVIQN MT DTT DMXVIQN RN MOR103, a human monoclonal antibody to granulocyte-macrophage colony-stimulating factor, in the treatment of patients with moderate rheumatoid arthritis: results of a phase Ib/IIa randomised, double-blind, placebo-controlled, dose-escalation trial. Ann Rheum Dis. 2015 Jun;74(6):1058-64. DMXVIQN RU https://pubmed.ncbi.nlm.nih.gov/24534756 DMR8AHJ DI DMR8AHJ DMR8AHJ DN MOR-202 DMR8AHJ MI TTPURFN DMR8AHJ MN Cyclic ADP-ribose hydrolase 1 (CD38) DMR8AHJ MT DTT DMR8AHJ RN Clinical pipeline report, company report or official report of MorphoSys. DMR8AHJ RU https://www.morphosys.com/pipeline/proprietary-product-portfolio/mor202 DMR3VCY DI DMR3VCY DMR3VCY DN MP0250 DMR3VCY MI TT4V2JM DMR3VCY MN Hepatocyte growth factor (HGF) DMR3VCY MT DTT DMR3VCY MA Inhibitor DMR3VCY RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMR3VCY RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DMR3VCY DI DMR3VCY DMR3VCY DN MP0250 DMR3VCY MI TTOHSBA DMR3VCY MN Vascular endothelial growth factor A (VEGFA) DMR3VCY MT DTT DMR3VCY MA Inhibitor DMR3VCY RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMR3VCY RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DME7PBN DI DME7PBN DME7PBN DN mRNA-3704 DME7PBN MI TTCQ21Y DME7PBN MN Methylmalonyl-CoA mutase (MMUT) DME7PBN MT DTT DME7PBN MA Replacement DME7PBN RN Clinical pipeline report, company report or official report of Moderna Therapeutics. DME7PBN RU https://www.modernatx.com/mrna-3705 DM35YFC DI DM35YFC DM35YFC DN MS-1819 DM35YFC MI TTXMY0J DM35YFC MN Pancreatic triacylglycerol lipase (PNLIP) DM35YFC MT DTT DM35YFC MA Modulator DM35YFC RN Clinical pipeline report, company report or official report of AzurRx. DM35YFC RU http://www.azurrx.com/news-events/press-releases/10-news-2014/58-http-www-azurrx-com-administrator-index-php-option-com-content-view-article-layout-edit DMIS75V DI DMIS75V DMIS75V DN MTL-CEPBA DMIS75V MI TT5LWG1 DMIS75V MN CEBPA messenger RNA (CEBPA mRNA) DMIS75V MT DTT DMIS75V MA Activator DMIS75V RN MTL-CEBPA, a Small Activating RNA Therapeutic Upregulating C/EBP-alpha, in Patients with Advanced Liver Cancer: A First-in-Human, Multicenter, Open-Label, Phase I Trial. Clin Cancer Res. 2020 Aug 1;26(15):3936-3946. DMIS75V RU https://pubmed.ncbi.nlm.nih.gov/32357963 DMFUDHM DI DMFUDHM DMFUDHM DN MUC-1 CART cell immunotherapy DMFUDHM MI TTBHFYQ DMFUDHM MN Mucin-1 (MUC1) DMFUDHM MT DTT DMFUDHM MA CAR-T-Cell-Therapy DMFUDHM RN ClinicalTrials.gov (NCT03633773) Safety and Efficacy Evaluation of MUC-1 CART in the Treatment of Intrahepatic Cholangiocarcinoma DMFUDHM RU https://clinicaltrials.gov/ct2/show/NCT03633773 DMPNR0J DI DMPNR0J DMPNR0J DN Muc1-specific gene-engineered T cells DMPNR0J MI TTBHFYQ DMPNR0J MN Mucin-1 (MUC1) DMPNR0J MT DTT DMPNR0J MA CAR-T-Cell-Therapy DMPNR0J RN ClinicalTrials.gov (NCT03222674) Multi-CAR T Cell Therapy for Acute Myeloid Leukemia DMPNR0J RU https://clinicaltrials.gov/ct2/show/NCT03222674 DMU6MJ1 DI DMU6MJ1 DMU6MJ1 DN NAHE-001 DMU6MJ1 MI TTLHGSF DMU6MJ1 MN Interferon-alpha 5 (IFNA5) DMU6MJ1 MT DTT DMU6MJ1 MA Modulator DMU6MJ1 RN Interferons and viral infections. Biofactors. 2009 Jan-Feb;35(1):14-20. DMU6MJ1 RU https://pubmed.ncbi.nlm.nih.gov/19319841 DM5O4GR DI DM5O4GR DM5O4GR DN NB1011 DM5O4GR MI TTU6BFZ DM5O4GR MN Candida Thymidylate synthase (Candi TMP1) DM5O4GR MT DTT DM5O4GR MA Binder DM5O4GR RN Kinetic properties of human thymidylate synthase, an anticancer drug target. Biochem Biophys Res Commun. 2003 Jul 25;307(2):297-300. DM5O4GR RU https://pubmed.ncbi.nlm.nih.gov/12859954 DMTAODR DI DMTAODR DMTAODR DN NBE-002 DMTAODR MI TTDEJAU DMTAODR MN Neurotrophic tyrosine kinase ROR1 (ROR1) DMTAODR MT DTT DMTAODR RN Clinical pipeline report, company report or official report of NBE-Therapeutics. DMTAODR RU https://www.nbe-therapeutics.com/technology/overview DMZSIV1 DI DMZSIV1 DMZSIV1 DN NC410 DMZSIV1 MI TTSI7A8 DMZSIV1 MN Leukocyte-associated Ig-like receptor 1 (LAIR1) DMZSIV1 MT DTT DMZSIV1 MA Inhibitor DMZSIV1 RN Clinical pipeline report, company report or official report of NextCure. DMZSIV1 RU http://www.nextcure.com/pipeline/ DMCDQX0 DI DMCDQX0 DMCDQX0 DN ND-0801 DMCDQX0 MI TTJSZTB DMCDQX0 MN Nicotinic acetylcholine receptor (nAChR) DMCDQX0 MT DTT DMCDQX0 MA Modulator DMCDQX0 RN Drugs in Clinical Development for Attention-Deficit/Hyperactivity Disorder: Summary and Table, 2013, Volume 27, Issue 4, 245-248. DMCDQX0 RU http://link.springer.com/article/10.1007/s40290-013-0026-2 DMPMF6L DI DMPMF6L DMPMF6L DN Nepadutant DMPMF6L MI TTYO0A3 DMPMF6L MN Substance-K receptor (TACR2) DMPMF6L MT DTT DMPMF6L MA Antagonist DMPMF6L RN Emerging drugs for postoperative ileus. Expert Opin Emerg Drugs. 2007 Nov;12(4):619-26. DMPMF6L RU https://pubmed.ncbi.nlm.nih.gov/17979603 DMXKOUC DI DMXKOUC DMXKOUC DN Neu-120 DMXKOUC MI TTRSMW9 DMXKOUC MN Glycogen synthase kinase-3 beta (GSK-3B) DMXKOUC MT DTT DMXKOUC MA Modulator DMXKOUC RN Company report (Neurim Pharmaceuticals) DMXKOUC RU http://www.neurim.com/products/ DMXKOUC DI DMXKOUC DMXKOUC DN Neu-120 DMXKOUC MI TTGP7BY DMXKOUC MN Monoamine oxidase type B (MAO-B) DMXKOUC MT DTT DMXKOUC MA Modulator DMXKOUC RN Company report (Neurim Pharmaceuticals) DMXKOUC RU http://www.neurim.com/products/ DMEOLVP DI DMEOLVP DMEOLVP DN NI-0401 DMEOLVP MI TTBMAOZ DMEOLVP MN Regulatory protein unspecific (RGP) DMEOLVP MT DTT DMEOLVP RN Clinical pipeline report, company report or official report of NovImmune. DMEOLVP RU http://www.novimmune.com/pipeline/ni-0401.html DMMOA2X DI DMMOA2X DMMOA2X DN Nikkomycin Z DMMOA2X MI TTBGVF1 DMMOA2X MN Candida Chitin synthase 3 (Candi CHS3) DMMOA2X MT DTT DMMOA2X MA Modulator DMMOA2X RN Inhibitory effect of nikkomycin Z on chitin synthases in Candida albicans. Yeast. 2002 Mar 15;19(4):341-9. DMMOA2X RU https://pubmed.ncbi.nlm.nih.gov/11870857 DM7SMNJ DI DM7SMNJ DM7SMNJ DN NKTR-255 DM7SMNJ MI TTGN89I DM7SMNJ MN Interleukin 15 receptor alpha (IL15RA) DM7SMNJ MT DTT DM7SMNJ MA Agonist DM7SMNJ RN Clinical pipeline report, company report or official report of Nektar Therapeutics. DM7SMNJ RU https://www.nektar.com/pipeline/rd-pipeline/nktr-255 DMYR8LF DI DMYR8LF DMYR8LF DN NKTR-262 DMYR8LF MI TTRJ1K4 DMYR8LF MN Toll-like receptor 7 (TLR7) DMYR8LF MT DTT DMYR8LF MA Agonist DMYR8LF RN Clinical pipeline report, company report or official report of Nektar Therapeutics. DMYR8LF RU https://www.nektar.com/pipeline/rd-pipeline/nktr-262 DMYR8LF DI DMYR8LF DMYR8LF DN NKTR-262 DMYR8LF MI TT8CWFK DMYR8LF MN Toll-like receptor 8 (TLR8) DMYR8LF MT DTT DMYR8LF MA Agonist DMYR8LF RN Clinical pipeline report, company report or official report of Nektar Therapeutics. DMYR8LF RU https://www.nektar.com/pipeline/rd-pipeline/nktr-262 DMDNJP5 DI DMDNJP5 DMDNJP5 DN NM21-1480 DMDNJP5 MI TTPW9LJ DMDNJP5 MN Co-stimulatory molecule 4-1BB (CD137) DMDNJP5 MT DTT DMDNJP5 MA Modulator DMDNJP5 RN Clinical pipeline report, company report or official report of Numab Therapeutics. DMDNJP5 RU https://www.numab.com/wp-content/uploads/2019/03/190330_PRE_Numab_AACR-Poster-2019.pdf DMDNJP5 DI DMDNJP5 DMDNJP5 DN NM21-1480 DMDNJP5 MI TT8ZLTI DMDNJP5 MN Programmed cell death 1 ligand 1 (PD-L1) DMDNJP5 MT DTT DMDNJP5 MA Modulator DMDNJP5 RN Clinical pipeline report, company report or official report of Numab Therapeutics. DMDNJP5 RU https://www.numab.com/wp-content/uploads/2019/03/190330_PRE_Numab_AACR-Poster-2019.pdf DMDASRW DI DMDASRW DMDASRW DN Norleucine DMDASRW MI TT01M3K DMDASRW MN Hepatocyte nuclear factor 1-alpha (HNF1A) DMDASRW MT DTT DMDASRW MA Inhibitor DMDASRW RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DMDASRW RU https://pubmed.ncbi.nlm.nih.gov/10592235 DM78KMT DI DM78KMT DM78KMT DN NPB-001-056 DM78KMT MI TTS7G69 DM78KMT MN Fusion protein Bcr-Abl (Bcr-Abl) DM78KMT MT DTT DM78KMT MA Inhibitor DM78KMT RN NPB001-05 inhibits Bcr-Abl kinase leading to apoptosis of imatinib-resistant cells. Front Biosci (Elite Ed). 2011 Jun 1;3:1273-88. DM78KMT RU https://pubmed.ncbi.nlm.nih.gov/21622134 DMU9BCD DI DMU9BCD DMU9BCD DN NS-018 DMU9BCD MI TTRMX3V DMU9BCD MN Janus kinase 2 (JAK-2) DMU9BCD MT DTT DMU9BCD MA Modulator DMU9BCD RN Effect of NS-018, a selective JAK2V617F inhibitor, in a murine model of myelofibrosis. Blood Cancer J. 2014 Jan 10;4:e174. DMU9BCD RU https://pubmed.ncbi.nlm.nih.gov/24413068 DMOYS1N DI DMOYS1N DMOYS1N DN NT219 DMOYS1N MI TTF95B8 DMOYS1N MN Insulin receptor substrate 2 (IRS2) DMOYS1N MT DTT DMOYS1N MA Inhibitor DMOYS1N RN Clinical pipeline report, company report or official report of Purple Biotech. DMOYS1N RU https://purple-biotech.com/pipeline/#1NT-219 DMOYS1N DI DMOYS1N DMOYS1N DN NT219 DMOYS1N MI TTADRX7 DMOYS1N MN Insulin receptor substrate-1 (IRS1) DMOYS1N MT DTT DMOYS1N MA Inhibitor DMOYS1N RN Clinical pipeline report, company report or official report of Purple Biotech. DMOYS1N RU https://purple-biotech.com/pipeline/#1NT-219 DMOYS1N DI DMOYS1N DMOYS1N DN NT219 DMOYS1N MI TTH8FZW DMOYS1N MN Signal transducer and activator of transcription 3 (STAT3) DMOYS1N MT DTT DMOYS1N MA Inhibitor DMOYS1N RN Clinical pipeline report, company report or official report of Purple Biotech. DMOYS1N RU https://purple-biotech.com/pipeline/#1NT-219 DMBQRGV DI DMBQRGV DMBQRGV DN NT-501 CNTF DMBQRGV MI TTGEM5Q DMBQRGV MN Ciliary neurotrophic factor (CNTF) DMBQRGV MT DTT DMBQRGV MA Modulator DMBQRGV RN Clinical pipeline report, company report or official report of Neurotech. DMBQRGV RU http://www.neurotechusa.com/cntfrenexus.html DMS0L6J DI DMS0L6J DMS0L6J DN NY-ESO-TCR DMS0L6J MI TT7AKW1 DMS0L6J MN T-cell receptor (TCR) DMS0L6J MT DTT DMS0L6J MA CAR-T-Cell-Therapy DMS0L6J RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMS0L6J RU http://phrma-docs.phrma.org/files/dmfile/MID_Immuno-Oncology-2017_Drug-List1.pdf DMD2L1U DI DMD2L1U DMD2L1U DN OBI-888 DMD2L1U MI TT4UXTG DMD2L1U MN Globohexaosylceramide (Globo H) DMD2L1U MT DTT DMD2L1U RN Clinical pipeline report, company report or official report of OBI Pharma. DMD2L1U RU https://www.obipharma.com/obi-888-mab/ DMPB9OD DI DMPB9OD DMPB9OD DN OBI-999 DMPB9OD MI TT4UXTG DMPB9OD MN Globohexaosylceramide (Globo H) DMPB9OD MT DTT DMPB9OD RN Preclinical Studies of OBI-999: A Novel Globo H-Targeting Antibody-Drug Conjugate. Mol Cancer Ther. 2021 Jun;20(6):1121-1132. DMPB9OD RU https://pubmed.ncbi.nlm.nih.gov/33722855 DM9MF08 DI DM9MF08 DM9MF08 DN OBP-301 DM9MF08 MI TTUJFD0 DM9MF08 MN Telomerase reverse transcriptase (TERT) DM9MF08 MT DTT DM9MF08 MA Inhibitor DM9MF08 RN Telomerase-specific replication-selective virotherapy for human cancer. Clin Cancer Res. 2004 Jan 1;10(1 Pt 1):285-92. DM9MF08 RU https://pubmed.ncbi.nlm.nih.gov/14734481 DMOKVJD DI DMOKVJD DMOKVJD DN ODM-207 DMOKVJD MI TTE4BSY DMOKVJD MN Bromodomain and extraterminal domain protein (BET) DMOKVJD MT DTT DMOKVJD MA Inhibitor DMOKVJD RN First-in-human Phase 1 open label study of the BET inhibitor ODM-207 in patients with selected solid tumours. Br J Cancer. 2020 Dec;123(12):1730-1736. DMOKVJD RU https://pubmed.ncbi.nlm.nih.gov/32989226 DMPLBDF DI DMPLBDF DMPLBDF DN Omburtamab I-124 DMPLBDF MI TT6CQUM DMPLBDF MN B7 homolog 3 (CD276) DMPLBDF MT DTT DMPLBDF MA Inhibitor DMPLBDF RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMPLBDF RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DM2DHJS DI DM2DHJS DM2DHJS DN ONC1-13B DM2DHJS MI TTS64P2 DM2DHJS MN Androgen receptor (AR) DM2DHJS MT DTT DM2DHJS MA Antagonist DM2DHJS RN Preclinical Development of ONC1-13B, Novel Antiandrogen for Prostate Cancer Treatment. J Cancer. 2014 Jan 21;5(2):133-42. DM2DHJS RU https://pubmed.ncbi.nlm.nih.gov/24494031 DMV6GX7 DI DMV6GX7 DMV6GX7 DN ONO-7475 DMV6GX7 MI TTO7LKR DMV6GX7 MN Tyrosine-protein kinase Mer (MERTK) DMV6GX7 MT DTT DMV6GX7 MA Inhibitor DMV6GX7 RN Clinical pipeline report, company report or official report of Ono Pharmaceutical. DMV6GX7 RU https://www.ono-pharma.com/ir/library/pipeline.html DMV6GX7 DI DMV6GX7 DMV6GX7 DN ONO-7475 DMV6GX7 MI TTZPY6J DMV6GX7 MN Tyrosine-protein kinase UFO (AXL) DMV6GX7 MT DTT DMV6GX7 MA Inhibitor DMV6GX7 RN Clinical pipeline report, company report or official report of Ono Pharmaceutical. DMV6GX7 RU https://www.ono-pharma.com/ir/library/pipeline.html DMXLPYE DI DMXLPYE DMXLPYE DN ONO-7579 DMXLPYE MI TTTDVOJ DMXLPYE MN Tropomyosin-related kinase A (TrkA) DMXLPYE MT DTT DMXLPYE MA Inhibitor DMXLPYE RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMXLPYE RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DMGIN7J DI DMGIN7J DMGIN7J DN Onyvax-105 DMGIN7J MI TT5Z9WY DMGIN7J MN Complement decay-accelerating factor (CD55) DMGIN7J MT DTT DMGIN7J RN Technology evaluation: Onyvax-105, Onyvax. Curr Opin Mol Ther. 2003 Dec;5(6):668-72. DMGIN7J RU https://pubmed.ncbi.nlm.nih.gov/14755894 DMIU26T DI DMIU26T DMIU26T DN OP-1250 DMIU26T MI TTZAYWL DMIU26T MN Estrogen receptor (ESR) DMIU26T MT DTT DMIU26T MA Antagonist DMIU26T RN Clinical pipeline report, company report or official report of Olema Pharmaceuticals. DMIU26T RU https://olema.com/pipeline/ DMELJIV DI DMELJIV DMELJIV DN OPA-6566 DMELJIV MI TTM2AOE DMELJIV MN Adenosine A2a receptor (ADORA2A) DMELJIV MT DTT DMELJIV MA Agonist DMELJIV RN Clinical pipeline report, company report or official report of Acucela. DMELJIV RU http://www.acucela.com/Read-About-Us/Press-Releases/Acucela-and-Otsuka-Pharmaceutical-Announce-the-(1) DM6VGO3 DI DM6VGO3 DM6VGO3 DN OPB-31121 DM6VGO3 MI TTH8FZW DM6VGO3 MN Signal transducer and activator of transcription 3 (STAT3) DM6VGO3 MT DTT DM6VGO3 MA Inhibitor DM6VGO3 RN OPB-31121, a novel small molecular inhibitor, disrupts the JAK2/STAT3 pathway and exhibits an antitumor activity in gastric cancer cells. Cancer Lett. 2013 Jul 10;335(1):145-52. DM6VGO3 RU https://pubmed.ncbi.nlm.nih.gov/23402820 DMZB6LO DI DMZB6LO DMZB6LO DN OPC-167832 DMZB6LO MI TTLOHU4 DMZB6LO MN Mycobacterium Decaprenylphosphoryl-beta-D-ribose oxidase (McyB dprE1) DMZB6LO MT DTT DMZB6LO MA Inhibitor DMZB6LO RN OPC-167832, a Novel Carbostyril Derivative with Potent Antituberculosis Activity as a DprE1 Inhibitor. Antimicrob Agents Chemother. 2020 May 21;64(6):e02020-19. DMZB6LO RU https://pubmed.ncbi.nlm.nih.gov/32229496 DM471ZH DI DM471ZH DM471ZH DN ORE-1001 DM471ZH MI TTUI5H7 DM471ZH MN Angiotensin-converting enzyme 2 (ACE2) DM471ZH MT DTT DM471ZH MA Inhibitor DM471ZH RN Effects of the ACE2 inhibitor GL1001 on acute dextran sodium sulfate-induced colitis in mice. Inflamm Res. 2009 Nov;58(11):819-27. DM471ZH RU https://pubmed.ncbi.nlm.nih.gov/19517214 DM27RXS DI DM27RXS DM27RXS DN ORIN1001 DM27RXS MI TTOJ9QL DM27RXS MN Endoplasmic reticulum to nucleus signaling 1 (ERN1) DM27RXS MT DTT DM27RXS MA Inhibitor DM27RXS RN Clinical pipeline report, company report or official report of Orinove. DM27RXS RU http://www.orinove.com/about261.html DMWCJ1F DI DMWCJ1F DMWCJ1F DN OT-58 DMWCJ1F MI TTVZJ7G DMWCJ1F MN Cystathionine beta-synthase (CBS) DMWCJ1F MT DTT DMWCJ1F MA Replacement DMWCJ1F RN Classical homocystinuria: From cystathionine beta-synthase deficiency to novel enzyme therapies. Biochimie. 2020 Jun;173:48-56. DMWCJ1F RU https://pubmed.ncbi.nlm.nih.gov/31857119 DMYGK1D DI DMYGK1D DMYGK1D DN OTL-300 DMYGK1D MI TTM6HK1 DMYGK1D MN Hemoglobin subunit beta (HBB) DMYGK1D MT DTT DMYGK1D RN Clinical pipeline report, company report or official report of Orchard Therapeutics. DMYGK1D RU https://www.orchard-tx.com/approach/pipeline/ DMN0ZQ5 DI DMN0ZQ5 DMN0ZQ5 DN OTSGC-A24 DMN0ZQ5 MI TT2Q6G1 DMN0ZQ5 MN Vascular endothelial growth factor receptor 1 (FLT-1) DMN0ZQ5 MT DTT DMN0ZQ5 RN J Clin Oncol 33, 2015 (suppl 3; abstr 65). DMN0ZQ5 RU http://meetinglibrary.asco.org/content/140443-158 DMN0ZQ5 DI DMN0ZQ5 DMN0ZQ5 DN OTSGC-A24 DMN0ZQ5 MI TTUTJGQ DMN0ZQ5 MN Vascular endothelial growth factor receptor 2 (KDR) DMN0ZQ5 MT DTT DMN0ZQ5 RN J Clin Oncol 33, 2015 (suppl 3; abstr 65). DMN0ZQ5 RU http://meetinglibrary.asco.org/content/140443-158 DMI8RG1 DI DMI8RG1 DMI8RG1 DN OTX-015 DMI8RG1 MI TTE4BSY DMI8RG1 MN Bromodomain and extraterminal domain protein (BET) DMI8RG1 MT DTT DMI8RG1 MA Inhibitor DMI8RG1 RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMI8RG1 RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DMI8RG1 DI DMI8RG1 DMI8RG1 DN OTX-015 DMI8RG1 MI TTDP48B DMI8RG1 MN Bromodomain-containing protein 2 (BRD2) DMI8RG1 MT DTT DMI8RG1 MA Modulator DMI8RG1 RN Targeting bromodomains: epigenetic readers of lysine acetylation.Nat Rev Drug Discov.2014 May;13(5):337-56. DMI8RG1 RU https://www.ncbi.nlm.nih.gov/pubmed/24751816 DMI8RG1 DI DMI8RG1 DMI8RG1 DN OTX-015 DMI8RG1 MI TTRA6BO DMI8RG1 MN Bromodomain-containing protein 4 (BRD4) DMI8RG1 MT DTT DMI8RG1 MA Modulator DMI8RG1 RN Targeting bromodomains: epigenetic readers of lysine acetylation.Nat Rev Drug Discov.2014 May;13(5):337-56. DMI8RG1 RU https://www.ncbi.nlm.nih.gov/pubmed/24751816 DMXF9DM DI DMXF9DM DMXF9DM DN OXB-102 DMXF9DM MI TTN451K DMXF9DM MN Aromatic-L-amino-acid decarboxylase (DDC) DMXF9DM MT DTT DMXF9DM RN Clinical pipeline report, company report or official report of Oxford BioMedica. DMXF9DM RU https://www.oxb.com/pipeline DMXF9DM DI DMXF9DM DMXF9DM DN OXB-102 DMXF9DM MI TTLSWP6 DMXF9DM MN GTP cyclohydrolase-I (GCH1) DMXF9DM MT DTT DMXF9DM RN Clinical pipeline report, company report or official report of Oxford BioMedica. DMXF9DM RU https://www.oxb.com/pipeline DMXF9DM DI DMXF9DM DMXF9DM DN OXB-102 DMXF9DM MI TTUHP71 DMXF9DM MN Tyrosine 3-monooxygenase (TH) DMXF9DM MT DTT DMXF9DM RN Clinical pipeline report, company report or official report of Oxford BioMedica. DMXF9DM RU https://www.oxb.com/pipeline DMTH75R DI DMTH75R DMTH75R DN OXY-111A DMTH75R MI TTQO71U DMTH75R MN Hemoglobin (HB) DMTH75R MT DTT DMTH75R MA Enhancer DMTH75R RN Modulating the oxygen affinity of human fetal haemoglobin with synthetic allosteric modulators. Br J Haematol. 1998 Sep;102(5):1165-71. DMTH75R RU https://pubmed.ncbi.nlm.nih.gov/9753039 DM6V5OB DI DM6V5OB DM6V5OB DN P-552-02 DM6V5OB MI TTRK8B9 DM6V5OB MN Sodium channel unspecific (NaC) DM6V5OB MT DTT DM6V5OB MA Blocker DM6V5OB RN US patent application no. 2014,0221,286, Sodium channel blockers reduce glucagon secretion. DM6V5OB RU https://www.google.com/patents/US20140221286 DMLSYJQ DI DMLSYJQ DMLSYJQ DN PA-799 DMLSYJQ MI TTEUNMR DMLSYJQ MN PI3-kinase alpha (PIK3CA) DMLSYJQ MT DTT DMLSYJQ MA Inhibitor DMLSYJQ RN The selective class I PI3K inhibitor CH5132799 targets human cancers harboring oncogenic PIK3CA mutations. Clin Cancer Res. 2011 May 15;17(10):3272-81. DMLSYJQ RU https://pubmed.ncbi.nlm.nih.gov/21558396 DMLSYJQ DI DMLSYJQ DMLSYJQ DN PA-799 DMLSYJQ MI TTTHBCA DMLSYJQ MN PI3-kinase beta (PIK3CB) DMLSYJQ MT DTT DMLSYJQ MA Inhibitor DMLSYJQ RN The selective class I PI3K inhibitor CH5132799 targets human cancers harboring oncogenic PIK3CA mutations. Clin Cancer Res. 2011 May 15;17(10):3272-81. DMLSYJQ RU https://pubmed.ncbi.nlm.nih.gov/21558396 DMLSYJQ DI DMLSYJQ DMLSYJQ DN PA-799 DMLSYJQ MI TTGBPJE DMLSYJQ MN PI3-kinase delta (PIK3CD) DMLSYJQ MT DTT DMLSYJQ MA Inhibitor DMLSYJQ RN The selective class I PI3K inhibitor CH5132799 targets human cancers harboring oncogenic PIK3CA mutations. Clin Cancer Res. 2011 May 15;17(10):3272-81. DMLSYJQ RU https://pubmed.ncbi.nlm.nih.gov/21558396 DMLSYJQ DI DMLSYJQ DMLSYJQ DN PA-799 DMLSYJQ MI TTHBTOP DMLSYJQ MN PI3-kinase gamma (PIK3CG) DMLSYJQ MT DTT DMLSYJQ MA Modulator DMLSYJQ RN Company report (Chugai-pharm) DMLSYJQ RU http://www.chugai-pharm.co.jp/html/meeting/pdf/140424ePresentation.pdf DMZKFJO DI DMZKFJO DMZKFJO DN PAT-SC1 DMZKFJO MI TT5Z9WY DMZKFJO MN Complement decay-accelerating factor (CD55) DMZKFJO MT DTT DMZKFJO RN Ten-year follow-up of a prospective trial for the targeted therapy of gastric cancer with the human monoclonal antibody PAT-SC1. Oncol Rep. 2014 Mar;31(3):1059-66. DMZKFJO RU https://pubmed.ncbi.nlm.nih.gov/24452482 DMJC2RU DI DMJC2RU DMJC2RU DN PBCAR0191 DMJC2RU MI TTW640A DMJC2RU MN B-lymphocyte surface antigen B4 (CD19) DMJC2RU MT DTT DMJC2RU MA CAR-T-Cell-Therapy DMJC2RU RN ClinicalTrials.gov (NCT03666000) Dose-escalation Study of Safety of PBCAR0191 in Patients With r/r NHL and r/r B-cell ALL DMJC2RU RU https://clinicaltrials.gov/ct2/show/NCT03666000 DM7NKWQ DI DM7NKWQ DM7NKWQ DN PBCAR20A DM7NKWQ MI TTUE541 DM7NKWQ MN Leukocyte surface antigen Leu-16 (CD20) DM7NKWQ MT DTT DM7NKWQ RN Clinical pipeline report, company report or official report of Precision Biosciences. DM7NKWQ RU https://precisionbiosciences.com/pipeline/ DMSGM2L DI DMSGM2L DMSGM2L DN PBCAR269A DMSGM2L MI TTZ3P4W DMSGM2L MN B-cell maturation protein (TNFRSF17) DMSGM2L MT DTT DMSGM2L RN Clinical pipeline report, company report or official report of Precision Biosciences. DMSGM2L RU https://precisionbiosciences.com/pipeline/ DMGFPQ0 DI DMGFPQ0 DMGFPQ0 DN PBF509 DMGFPQ0 MI TTM2AOE DMGFPQ0 MN Adenosine A2a receptor (ADORA2A) DMGFPQ0 MT DTT DMGFPQ0 MA Antagonist DMGFPQ0 RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMGFPQ0 RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DMSJ54W DI DMSJ54W DMSJ54W DN PC14586 DMSJ54W MI TTJC50M DMSJ54W MN P53 Y220C mutant (TP53 Y220C) DMSJ54W MT DTT DMSJ54W MA Reactivator DMSJ54W RN Clinical pipeline report, company report or official report of PMV Pharmaceuticals. DMSJ54W RU https://www.pmvpharma.com/pipeline/ DM9DR13 DI DM9DR13 DM9DR13 DN PCAR-019 DM9DR13 MI TTW640A DM9DR13 MN B-lymphocyte surface antigen B4 (CD19) DM9DR13 MT DTT DM9DR13 MA CAR-T-Cell-Therapy DM9DR13 RN ClinicalTrials.gov (NCT02819583) CAR-T Cell Immunotherapy in CD19 Positive Relapsed or Refractory Leukemia and Lymphoma DM9DR13 RU https://clinicaltrials.gov/ct2/show/NCT02819583 DM1D6BT DI DM1D6BT DM1D6BT DN PEGylated hyaluronidase (human recombinant) DM1D6BT MI TTXFI1K DM1D6BT MN Hyaluronidase (HYAL) DM1D6BT MT DTT DM1D6BT MA Modulator DM1D6BT RN Targeting the tumor microenvironment in cancer: why hyaluronidase deserves a second look. Cancer Discov. 2011 September; 1(4): 291-296. DM1D6BT RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3204883/ DMMAUOK DI DMMAUOK DMMAUOK DN PEN-221 DMMAUOK MI TTZ6T9E DMMAUOK MN Somatostatin receptor type 2 (SSTR2) DMMAUOK MT DTT DMMAUOK MA Modulator DMMAUOK RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMMAUOK RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DMLPTOF DI DMLPTOF DMLPTOF DN PEN-866 DMLPTOF MI TTGTQHC DMLPTOF MN DNA topoisomerase I (TOP1) DMLPTOF MT DTT DMLPTOF MA Inhibitor DMLPTOF RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMLPTOF RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DMM9L1R DI DMM9L1R DMM9L1R DN PEP-223/CoVaccine HT DMM9L1R MI TT8R70G DMM9L1R MN Gonadotropin-releasing hormone receptor (GNRHR) DMM9L1R MT DTT DMM9L1R RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 256). DMM9L1R RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=256 DM03GDJ DI DM03GDJ DM03GDJ DN Pepinemab DM03GDJ MI TT5UT28 DM03GDJ MN Semaphorin-4D (SEMA4D) DM03GDJ MT DTT DM03GDJ MA Inhibitor DM03GDJ RN Clinical pipeline report, company report or official report of Vaccinex. DM03GDJ RU https://vaccinex.com/pipeline/pepinemab-immuno-oncology/ DMBUJVX DI DMBUJVX DMBUJVX DN Phenoxodiol DMBUJVX MI TTOHFIY DMBUJVX MN Sphingosine kinase 1 (SPHK1) DMBUJVX MT DTT DMBUJVX MA Modulator DMBUJVX RN Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41. DMBUJVX RU https://www.ncbi.nlm.nih.gov/pubmed/15950434 DMBUJVX DI DMBUJVX DMBUJVX DN Phenoxodiol DMBUJVX MI TTR7B60 DMBUJVX MN X-linked inhibitor of apoptosis protein (XIAP) DMBUJVX MT DTT DMBUJVX MA Modulator DMBUJVX RN Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41. DMBUJVX RU https://www.ncbi.nlm.nih.gov/pubmed/15950434 DMYEAB1 DI DMYEAB1 DMYEAB1 DN PIPERINE DMYEAB1 MI TT3WG5C DMYEAB1 MN Monoamine oxidase type A (MAO-A) DMYEAB1 MT DTT DMYEAB1 MA Inhibitor DMYEAB1 RN Proposed structural basis of interaction of piperine and related compounds with monoamine oxidases. Bioorg Med Chem Lett. 2010 Jan 15;20(2):537-40. DMYEAB1 RU https://pubmed.ncbi.nlm.nih.gov/19969454 DMYEAB1 DI DMYEAB1 DMYEAB1 DN PIPERINE DMYEAB1 MI TTGP7BY DMYEAB1 MN Monoamine oxidase type B (MAO-B) DMYEAB1 MT DTT DMYEAB1 MA Inhibitor DMYEAB1 RN Proposed structural basis of interaction of piperine and related compounds with monoamine oxidases. Bioorg Med Chem Lett. 2010 Jan 15;20(2):537-40. DMYEAB1 RU https://pubmed.ncbi.nlm.nih.gov/19969454 DMX168L DI DMX168L DMX168L DN PLX2853 DMX168L MI TTRA6BO DMX168L MN Bromodomain-containing protein 4 (BRD4) DMX168L MT DTT DMX168L MA Inhibitor DMX168L RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMX168L RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DM5DZEL DI DM5DZEL DM5DZEL DN PLX9486 DM5DZEL MI TTX41N9 DM5DZEL MN Tyrosine-protein kinase Kit (KIT) DM5DZEL MT DTT DM5DZEL MA Inhibitor DM5DZEL RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DM5DZEL RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DMQOW0H DI DMQOW0H DMQOW0H DN PP-1420 DMQOW0H MI TTIB95A DMQOW0H MN Pancreatic hormone (PH) DMQOW0H MT DTT DMQOW0H MA Modulator DMQOW0H RN Pharmacokinetics, adverse effects and tolerability of a novel analogue of human pancreatic polypeptide, PP 1420. Br J Clin Pharmacol. 2012 Feb;73(2):232-9. DMQOW0H RU https://pubmed.ncbi.nlm.nih.gov/21834938 DM0HTEF DI DM0HTEF DM0HTEF DN PRI-724 DM0HTEF MI TTFRCTK DM0HTEF MN CREB-binding protein (CREBBP) DM0HTEF MT DTT DM0HTEF MA Modulator DM0HTEF RN Inhibition of Wnt/beta-catenin/CREB binding protein (CBP) signaling reverses pulmonary fibrosis. Proc Natl Acad Sci U S A. 2010 Aug 10;107(32):14309-14. DM0HTEF RU https://pubmed.ncbi.nlm.nih.gov/20660310 DM8J5H1 DI DM8J5H1 DM8J5H1 DN PRLX93936 DM8J5H1 MI TTT48SQ DM8J5H1 MN Voltage-dependent anion-selective channel 3 (VDAC3) DM8J5H1 MT DTT DM8J5H1 MA Modulator DM8J5H1 RN Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41. DM8J5H1 RU https://www.ncbi.nlm.nih.gov/pubmed/15950434 DMJ42E6 DI DMJ42E6 DMJ42E6 DN ProSavin DMJ42E6 MI TTN451K DMJ42E6 MN Aromatic-L-amino-acid decarboxylase (DDC) DMJ42E6 MT DTT DMJ42E6 MA Modulator DMJ42E6 RN Clinical pipeline report, company report or official report of Oxford BioMedica. DMJ42E6 RU http://www.oxfordbiomedica.co.uk/press-releases/oxford-biomedica-announces-successful-completion-of-prosavin-r-phase-i-ii-study-in-parkinson-s-disease/ DMJ42E6 DI DMJ42E6 DMJ42E6 DN ProSavin DMJ42E6 MI TTLSWP6 DMJ42E6 MN GTP cyclohydrolase-I (GCH1) DMJ42E6 MT DTT DMJ42E6 MA Modulator DMJ42E6 RN Clinical pipeline report, company report or official report of Oxford BioMedica. DMJ42E6 RU http://www.oxfordbiomedica.co.uk/press-releases/oxford-biomedica-announces-successful-completion-of-prosavin-r-phase-i-ii-study-in-parkinson-s-disease/ DMJ42E6 DI DMJ42E6 DMJ42E6 DN ProSavin DMJ42E6 MI TTUHP71 DMJ42E6 MN Tyrosine 3-monooxygenase (TH) DMJ42E6 MT DTT DMJ42E6 MA Modulator DMJ42E6 RN Clinical pipeline report, company report or official report of Oxford BioMedica. DMJ42E6 RU http://www.oxfordbiomedica.co.uk/press-releases/oxford-biomedica-announces-successful-completion-of-prosavin-r-phase-i-ii-study-in-parkinson-s-disease/ DMOUW65 DI DMOUW65 DMOUW65 DN PRX-102 DMOUW65 MI TTIS03D DMOUW65 MN Alpha-galactosidase A (GLA) DMOUW65 MT DTT DMOUW65 MA Modulator DMOUW65 RN Characterization of a chemically modified plant cell culture expressed human alpha-Galactosidase-A enzyme for treatment of Fabry disease. Mol Genet Metab. 2015 Feb;114(2):259-67. DMOUW65 RU https://pubmed.ncbi.nlm.nih.gov/25155442 DM2CDLS DI DM2CDLS DM2CDLS DN QLT-091568 DM2CDLS MI TTMXGCW DM2CDLS MN Adrenergic receptor beta-3 (ADRB3) DM2CDLS MT DTT DM2CDLS MA Antagonist DM2CDLS RN Clinical pipeline report, company report or official report of QLT Inc. DM2CDLS RU http://www.qltinc.com/newsCenter/2009/091230.htm DMZD7OA DI DMZD7OA DMZD7OA DN Quaratusugene ozeplasmid DMZD7OA MI TTJ8O14 DMZD7OA MN Tumor suppressor candidate 2 (TUSC2) DMZD7OA MT DTT DMZD7OA RN Clinical pipeline report, company report or official report of Genprex. DMZD7OA RU https://www.genprex.com/technology/reqorsa/ DM614BA DI DM614BA DM614BA DN Re-188-P-2045 DM614BA MI TTZ6T9E DM614BA MN Somatostatin receptor type 2 (SSTR2) DM614BA MT DTT DM614BA MA Modulator DM614BA RN The somatostatin analog 188Re-P2045 inhibits the growth of AR42J pancreatic tumor xenografts. J Nucl Med. 2014 Dec;55(12):2020-5. DM614BA RU https://pubmed.ncbi.nlm.nih.gov/25359879 DMY3TAD DI DMY3TAD DMY3TAD DN Recombinant factor VIIa PEGylated liposomal DMY3TAD MI TTF0EGX DMY3TAD MN Coagulation factor VII (F7) DMY3TAD MT DTT DMY3TAD MA Modulator DMY3TAD RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2363). DMY3TAD RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2363 DM7LOSK DI DM7LOSK DM7LOSK DN REGN4018 DM7LOSK MI TTC1PS3 DM7LOSK MN Ovarian carcinoma antigen CA125 (MUC16) DM7LOSK MT DTT DM7LOSK MA Inhibitor DM7LOSK RN A Mucin 16 bispecific T cell-engaging antibody for the treatment of ovarian cancer. Sci Transl Med. 2019 Jun 19;11(497):eaau7534. DM7LOSK RU https://pubmed.ncbi.nlm.nih.gov/31217340 DM7LOSK DI DM7LOSK DM7LOSK DN REGN4018 DM7LOSK MI TTUN7MC DM7LOSK MN T-cell surface glycoprotein CD3 (CD3) DM7LOSK MT DTT DM7LOSK MA Inhibitor DM7LOSK RN A Mucin 16 bispecific T cell-engaging antibody for the treatment of ovarian cancer. Sci Transl Med. 2019 Jun 19;11(497):eaau7534. DM7LOSK RU https://pubmed.ncbi.nlm.nih.gov/31217340 DMAGX0Q DI DMAGX0Q DMAGX0Q DN REGN5458 DMAGX0Q MI TTZ3P4W DMAGX0Q MN B-cell maturation protein (TNFRSF17) DMAGX0Q MT DTT DMAGX0Q MA Inhibitor DMAGX0Q RN A BCMAxCD3 bispecific T cell-engaging antibody demonstrates robust antitumor efficacy similar to that of anti-BCMA CAR T cells. Blood Adv. 2021 Mar 9;5(5):1291-1304. DMAGX0Q RU https://pubmed.ncbi.nlm.nih.gov/33651100 DMAGX0Q DI DMAGX0Q DMAGX0Q DN REGN5458 DMAGX0Q MI TTUN7MC DMAGX0Q MN T-cell surface glycoprotein CD3 (CD3) DMAGX0Q MT DTT DMAGX0Q MA Inhibitor DMAGX0Q RN A BCMAxCD3 bispecific T cell-engaging antibody demonstrates robust antitumor efficacy similar to that of anti-BCMA CAR T cells. Blood Adv. 2021 Mar 9;5(5):1291-1304. DMAGX0Q RU https://pubmed.ncbi.nlm.nih.gov/33651100 DMRE0LU DI DMRE0LU DMRE0LU DN REGN5459 DMRE0LU MI TTZ3P4W DMRE0LU MN B-cell maturation protein (TNFRSF17) DMRE0LU MT DTT DMRE0LU MA Inhibitor DMRE0LU RN Clinical pipeline report, company report or official report of Regeneron Pharmaceuticals. DMRE0LU RU https://www.regeneron.com/science/pipeline DMRE0LU DI DMRE0LU DMRE0LU DN REGN5459 DMRE0LU MI TTUN7MC DMRE0LU MN T-cell surface glycoprotein CD3 (CD3) DMRE0LU MT DTT DMRE0LU MA Inhibitor DMRE0LU RN Clinical pipeline report, company report or official report of Regeneron Pharmaceuticals. DMRE0LU RU https://www.regeneron.com/science/pipeline DM0Y6WU DI DM0Y6WU DM0Y6WU DN REGN5678 DM0Y6WU MI TT9G4N0 DM0Y6WU MN Glutamate carboxypeptidase II (GCPII) DM0Y6WU MT DTT DM0Y6WU MA Inhibitor DM0Y6WU RN Clinical pipeline report, company report or official report of Regeneron Pharmaceuticals. DM0Y6WU RU https://www.regeneron.com/science/pipeline DM0Y6WU DI DM0Y6WU DM0Y6WU DN REGN5678 DM0Y6WU MI TTQ13FT DM0Y6WU MN T-cell-specific surface glycoprotein CD28 (CD28) DM0Y6WU MT DTT DM0Y6WU MA Inhibitor DM0Y6WU RN Clinical pipeline report, company report or official report of Regeneron Pharmaceuticals. DM0Y6WU RU https://www.regeneron.com/science/pipeline DM5MFHO DI DM5MFHO DM5MFHO DN REIC gene therapy DM5MFHO MI TTY2ZV6 DM5MFHO MN Dickkopf-related protein 3 (DKK3) DM5MFHO MT DTT DM5MFHO MA Modulator DM5MFHO RN Potential of adenovirus-mediated REIC/Dkk-3 gene therapy for use in the treatment of pancreatic cancer. J Gastroenterol Hepatol. 2014 May;29(5):973-83. DM5MFHO RU https://pubmed.ncbi.nlm.nih.gov/24372695 DMDO6J1 DI DMDO6J1 DMDO6J1 DN Retroviral vector-transduced autologous T cells to express anti-GPC3 CARs DMDO6J1 MI TTJTSX4 DMDO6J1 MN Glypican-3 (GPC3) DMDO6J1 MT DTT DMDO6J1 MA CAR-T-Cell-Therapy DMDO6J1 RN ClinicalTrials.gov (NCT03084380) Anti-GPC3 CAR-T for Treating GPC3-positive Advanced Hepatocellular Carcinoma (HCC) DMDO6J1 RU https://clinicaltrials.gov/ct2/show/NCT03084380 DMAGE91 DI DMAGE91 DMAGE91 DN RG7800 DMAGE91 MI TT8QL6X DMAGE91 MN Survival motor neuron protein (SMN1) DMAGE91 MT DTT DMAGE91 MA Modulator DMAGE91 RN Assays for the Identification and Prioritization of Drug Candidates for Spinal Muscular Atrophy. Assay Drug Dev Technol. 2014 August 1; 12(6): 315-341. DMAGE91 RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4142828/ DM5AIKR DI DM5AIKR DM5AIKR DN RGX-104 DM5AIKR MI TTM1EQF DM5AIKR MN Oxysterols receptor LXR (NR1H) DM5AIKR MT DTT DM5AIKR MA Agonist DM5AIKR RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DM5AIKR RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DMU3PD7 DI DMU3PD7 DMU3PD7 DN RGX-121 DMU3PD7 MI TTNY2AP DMU3PD7 MN Iduronate 2-sulfatase (IDS) DMU3PD7 MT DTT DMU3PD7 MA Replacement DMU3PD7 RN Clinical pipeline report, company report or official report of REGENXBIO. DMU3PD7 RU https://www.regenxbio.com/rgx-121/ DMSDZ8U DI DMSDZ8U DMSDZ8U DN Rintatolimod DMSDZ8U MI TT1CN09 DMSDZ8U MN HUMAN toll-like receptor 3 (TLR3) DMSDZ8U MT DTT DMSDZ8U MA Agonist DMSDZ8U RN Efficacy of rintatolimod in the treatment of chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME). Expert Rev Clin Pharmacol. 2016 Jun;9(6):755-70. DMSDZ8U RU https://pubmed.ncbi.nlm.nih.gov/27045557 DM9FNC8 DI DM9FNC8 DM9FNC8 DN RP-3500 DM9FNC8 MI TT8ZYBQ DM9FNC8 MN Serine/threonine-protein kinase ATR (FRP1) DM9FNC8 MT DTT DM9FNC8 MA Inhibitor DM9FNC8 RN Clinical pipeline report, company report or official report of Repare Therapeutics. DM9FNC8 RU https://www.reparerx.com/pipeline/ DMKVMWO DI DMKVMWO DMKVMWO DN RP-L201 DMKVMWO MI TTIJWR7 DMKVMWO MN Integrin beta-2 (ITGB2) DMKVMWO MT DTT DMKVMWO MA Replacement DMKVMWO RN Clinical pipeline report, company report or official report of Rocket Pharmaceuticals. DMKVMWO RU https://rocketpharma.com/our-disease-focus/ DMXYHC7 DI DMXYHC7 DMXYHC7 DN RU-101 DMXYHC7 MI TTFNGC9 DMXYHC7 MN Serum albumin (ALB) DMXYHC7 MT DTT DMXYHC7 MA Modulator DMXYHC7 RN Albumin as a tear supplement in the treatment of severe dry eye. Br J Ophthalmol. 2003 October; 87(10): 1279-1283. DMXYHC7 RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1920766/ DM1LO8K DI DM1LO8K DM1LO8K DN RVX-208 DM1LO8K MI TTRA6BO DM1LO8K MN Bromodomain-containing protein 4 (BRD4) DM1LO8K MT DTT DM1LO8K MA Modulator DM1LO8K RN Targeting bromodomains: epigenetic readers of lysine acetylation.Nat Rev Drug Discov.2014 May;13(5):337-56. DM1LO8K RU https://www.ncbi.nlm.nih.gov/pubmed/24751816 DMCBQTF DI DMCBQTF DMCBQTF DN S-3304 DMCBQTF MI TT1GHVO DMCBQTF MN Matrix metalloproteinase (MMP) DMCBQTF MT DTT DMCBQTF MA Inhibitor DMCBQTF RN Safety, tolerability and pharmacokinetics of oral S-3304, a novel matrix metalloproteinase inhibitor, in single and multiple dose escalation studies in healthy volunteers. Int J Clin Pharmacol Ther. 2005 Jun;43(6):282-93. DMCBQTF RU https://pubmed.ncbi.nlm.nih.gov/15968885 DMVKQT8 DI DMVKQT8 DMVKQT8 DN SALACINOL DMVKQT8 MI TTXWASR DMVKQT8 MN Intestinal maltase-glucoamylase (MGAM) DMVKQT8 MT DTT DMVKQT8 MA Inhibitor DMVKQT8 RN Probing the active-site requirements of human intestinal N-terminal maltase-glucoamylase: Synthesis and enzyme inhibitory activities of a six-membe... Bioorg Med Chem. 2010 Nov 15;18(22):7794-8. DMVKQT8 RU https://pubmed.ncbi.nlm.nih.gov/20970346 DMVKQT8 DI DMVKQT8 DMVKQT8 DN SALACINOL DMVKQT8 MI TTLPC70 DMVKQT8 MN Lysosomal alpha-glucosidase (GAA) DMVKQT8 MT DTT DMVKQT8 MA Inhibitor DMVKQT8 RN Alpha-glucosidase inhibitor from Kothala-himbutu (Salacia reticulata WIGHT). J Nat Prod. 2008 Jun;71(6):981-4. DMVKQT8 RU https://pubmed.ncbi.nlm.nih.gov/18547114 DMPXOGD DI DMPXOGD DMPXOGD DN SAR-161271 DMPXOGD MI TTZOPHG DMPXOGD MN Insulin (INS) DMPXOGD MT DTT DMPXOGD MA Modulator DMPXOGD RN Clinical pipeline report, company report or official report of sanofi-aventis. DMPXOGD RU http://en.sanofi.com/img/content/study/TDU10987_summary.pdf DM6M8O4 DI DM6M8O4 DM6M8O4 DN SAR440234 DM6M8O4 MI TTENHJ0 DM6M8O4 MN Interleukin 3 receptor alpha (IL3RA) DM6M8O4 MT DTT DM6M8O4 RN Bispecific antibodies: a mechanistic review of the pipeline. Nat Rev Drug Discov. 2019 Aug;18(8):585-608. DM6M8O4 RU https://pubmed.ncbi.nlm.nih.gov/31175342 DM6M8O4 DI DM6M8O4 DM6M8O4 DN SAR440234 DM6M8O4 MI TTUN7MC DM6M8O4 MN T-cell surface glycoprotein CD3 (CD3) DM6M8O4 MT DTT DM6M8O4 RN Bispecific antibodies: a mechanistic review of the pipeline. Nat Rev Drug Discov. 2019 Aug;18(8):585-608. DM6M8O4 RU https://pubmed.ncbi.nlm.nih.gov/31175342 DMD20YH DI DMD20YH DMD20YH DN SAR-650984 DMD20YH MI TTPURFN DMD20YH MN Cyclic ADP-ribose hydrolase 1 (CD38) DMD20YH MT DTT DMD20YH RN Clinical pipeline report, company report or official report of Sanofi-Aventis. DMD20YH RU https://www.sanofioncology.com/m/pipeline/SAR650984.aspx DMA8Z4N DI DMA8Z4N DMA8Z4N DN SB-318 DMA8Z4N MI TT0IUKX DMA8Z4N MN Alpha-L-iduronidase (IDUA) DMA8Z4N MT DTT DMA8Z4N MA Replacement DMA8Z4N RN ClinicalTrials.gov (NCT02702115) Ascending Dose Study of Genome Editing by the Zinc Finger Nuclease (ZFN) Therapeutic SB-318 in Subjects With MPS I. U.S. National Institutes of Health. DMA8Z4N RU https://clinicaltrials.gov/ct2/show/NCT02702115 DM98YFK DI DM98YFK DM98YFK DN SB-913 DM98YFK MI TTNY2AP DM98YFK MN Iduronate 2-sulfatase (IDS) DM98YFK MT DTT DM98YFK MA Replacement DM98YFK RN ClinicalTrials.gov (NCT03041324) Ascending Dose Study of Genome Editing by the Zinc Finger Nuclease (ZFN) Therapeutic SB-913 in Subjects With MPS II. U.S. National Institutes of Health. DM98YFK RU https://clinicaltrials.gov/ct2/show/NCT03041324 DMUP52Y DI DMUP52Y DMUP52Y DN SB-FIX DMUP52Y MI TTFEZ5Q DMUP52Y MN Coagulation factor IX (F9) DMUP52Y MT DTT DMUP52Y MA Replacement DMUP52Y RN ClinicalTrials.gov (NCT02695160) Ascending Dose Study of Genome Editing by Zinc Finger Nuclease Therapeutic SB-FIX in Subjects With Severe Hemophilia B. U.S. National Institutes of Health. DMUP52Y RU https://clinicaltrials.gov/ct2/show/NCT02695160 DMS1NMO DI DMS1NMO DMS1NMO DN SCRI-huCAR19v1 DMS1NMO MI TTW640A DMS1NMO MN B-lymphocyte surface antigen B4 (CD19) DMS1NMO MT DTT DMS1NMO MA CAR-T-Cell-Therapy DMS1NMO RN ClinicalTrials.gov (NCT03684889) CD19-specific CAR T Cells With a Fully Human Binding Domain for CD19+ Leukemia or Lymphoma DMS1NMO RU https://clinicaltrials.gov/ct2/show/NCT03684889 DMBFUOI DI DMBFUOI DMBFUOI DN SECTA belomycin DMBFUOI MI TTUTN1I DMBFUOI MN Human Deoxyribonucleic acid (hDNA) DMBFUOI MT DTT DMBFUOI MA Binder DMBFUOI RN Site-specific cleavage of RNA and DNA by complementary DNA--bleomycin A5 conjugates. Bioconjug Chem. 2003 Nov-Dec;14(6):1307-13. DMBFUOI RU https://pubmed.ncbi.nlm.nih.gov/14624648 DMD37Q5 DI DMD37Q5 DMD37Q5 DN SEL24 DMD37Q5 MI TTGJCWZ DMD37Q5 MN Fms-like tyrosine kinase 3 (FLT-3) DMD37Q5 MT DTT DMD37Q5 MA Inhibitor DMD37Q5 RN A novel, dual pan-PIM/FLT3 inhibitor SEL24 exhibits broad therapeutic potential in acute myeloid leukemia. Oncotarget. 2018 Mar 30;9(24):16917-16931. DMD37Q5 RU https://pubmed.ncbi.nlm.nih.gov/29682194 DMD37Q5 DI DMD37Q5 DMD37Q5 DN SEL24 DMD37Q5 MI TTA7WGU DMD37Q5 MN Serine/threonine-protein kinase pim (PIM) DMD37Q5 MT DTT DMD37Q5 MA Inhibitor DMD37Q5 RN A novel, dual pan-PIM/FLT3 inhibitor SEL24 exhibits broad therapeutic potential in acute myeloid leukemia. Oncotarget. 2018 Mar 30;9(24):16917-16931. DMD37Q5 RU https://pubmed.ncbi.nlm.nih.gov/29682194 DMH064K DI DMH064K DMH064K DN SEL-24 DMH064K MI TTGJCWZ DMH064K MN Fms-like tyrosine kinase 3 (FLT-3) DMH064K MT DTT DMH064K MA Inhibitor DMH064K RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMH064K RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DMH064K DI DMH064K DMH064K DN SEL-24 DMH064K MI TTTN5QW DMH064K MN Serine/threonine-protein kinase pim-1 (PIM1) DMH064K MT DTT DMH064K MA Inhibitor DMH064K RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2158). DMH064K RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2158 DM4NK3J DI DM4NK3J DM4NK3J DN SF0166 DM4NK3J MI TT69TQN DM4NK3J MN Integrin alpha-V/beta-3 (ITGAV/B3) DM4NK3J MT DTT DM4NK3J MA Antagonist DM4NK3J RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DM4NK3J RU http://phrma-docs.phrma.org/files/dmfile/mid-diabetes-drug-list.pdf DMRC7PI DI DMRC7PI DMRC7PI DN SGN-CD33A DMRC7PI MI TTJVYO3 DMRC7PI MN Myeloid cell surface antigen CD33 (CD33) DMRC7PI MT DTT DMRC7PI RN SGN-CD33A: a novel CD33-targeting antibody-drug conjugate using a pyrrolobenzodiazepine dimer is active in models of drug-resistant AML. Blood. 2013 Aug 22;122(8):1455-63. DMRC7PI RU https://pubmed.ncbi.nlm.nih.gov/23770776 DMADNY3 DI DMADNY3 DMADNY3 DN SHR-1314 DMADNY3 MI TTG0MT6 DMADNY3 MN Interleukin-17 (IL17) DMADNY3 MT DTT DMADNY3 MA Inhibitor DMADNY3 RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMADNY3 RU http://phrma-docs.phrma.org/files/dmfile/MID_Skin_Diseases_2018_9_FINAL.pdf DMMUCH0 DI DMMUCH0 DMMUCH0 DN SHR2554 DMMUCH0 MI TT9MZCQ DMMUCH0 MN Enhancer of zeste homolog 2 (EZH2) DMMUCH0 MT DTT DMMUCH0 MA Inhibitor DMMUCH0 RN Epigenetics and beyond: targeting writers of protein lysine methylation to treat disease. Nat Rev Drug Discov. 2021 Apr;20(4):265-286. DMMUCH0 RU https://pubmed.ncbi.nlm.nih.gov/33469207 DMZTQD8 DI DMZTQD8 DMZTQD8 DN Sirna-027 DMZTQD8 MI TT1VAUK DMZTQD8 MN VEGFR1 messenger RNA (VEGFR1 mRNA) DMZTQD8 MT DTT DMZTQD8 RN 2011 Pipeline of Sirna Therapeutics. DMZTQD8 RU http://www.sirna.com/ DMSOX57 DI DMSOX57 DMSOX57 DN SJCAR19 DMSOX57 MI TTW640A DMSOX57 MN B-lymphocyte surface antigen B4 (CD19) DMSOX57 MT DTT DMSOX57 MA CAR-T-Cell-Therapy DMSOX57 RN ClinicalTrials.gov (NCT03573700) Evaluation of CD19-Specific CAR Engineered Autologous T-Cells for Treatment of Relapsed/Refractory CD19+ Acute Lymphoblastic Leukemia DMSOX57 RU https://clinicaltrials.gov/ct2/show/NCT03573700 DMSTEFK DI DMSTEFK DMSTEFK DN SKB264 DMSTEFK MI TTP2HE5 DMSTEFK MN Tumor associated calcium signal transducer 2 (TACSTD2) DMSTEFK MT DTT DMSTEFK RN ClinicalTrials.gov (NCT04152499) Phase I-II, FIH, TROP2 ADC, Advanced Unresectable/Metastatic Solid Tumors, Refractory to Standard Therapies (A264). U.S. National Institutes of Health. DMSTEFK RU https://clinicaltrials.gov/ct2/show/NCT04152499 DMOCHVE DI DMOCHVE DMOCHVE DN SL-401 DMOCHVE MI TTPYS82 DMOCHVE MN Interleukin 3 receptor (CSF2RB) DMOCHVE MT DTT DMOCHVE MA Inhibitor DMOCHVE RN Activity of SL-401, a targeted therapy directed to interleukin-3 receptor, in blastic plasmacytoid dendritic cell neoplasm patients. Blood. 2014 Jul 17;124(3):385-92. DMOCHVE RU https://pubmed.ncbi.nlm.nih.gov/24859366 DMEJT5Z DI DMEJT5Z DMEJT5Z DN SN-32793 DMEJT5Z MI TTGKNB4 DMEJT5Z MN Epidermal growth factor receptor (EGFR) DMEJT5Z MT DTT DMEJT5Z MA Inhibitor DMEJT5Z RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1797). DMEJT5Z RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1797 DMCGX9Y DI DMCGX9Y DMCGX9Y DN SNDX-5613 DMCGX9Y MI TT0CZBQ DMCGX9Y MN Menin-MLL1 interaction (MEN1-KMT2A PPI) DMCGX9Y MT DTT DMCGX9Y MA Inhibitor DMCGX9Y RN Clinical pipeline report, company report or official report of Syndax Pharmaceuticals. DMCGX9Y RU https://syndax.com/pipeline/sndx-5613/ DMNV8SY DI DMNV8SY DMNV8SY DN SNN-0029 DMNV8SY MI TTOHSBA DMNV8SY MN Vascular endothelial growth factor A (VEGFA) DMNV8SY MT DTT DMNV8SY MA Modulator DMNV8SY RN Clinical pipeline report, company report or official report of Neuronova. DMNV8SY RU http://www.neuronova.com/index.php?option=com_content&task=view&id=40&Itemid=71 DM2X3BR DI DM2X3BR DM2X3BR DN SNN-0031 DM2X3BR MI TTI7421 DM2X3BR MN Platelet-derived growth factor receptor beta (PDGFRB) DM2X3BR MT DTT DM2X3BR MA Modulator DM2X3BR RN Company report (Neuronova) DM2X3BR RU http://www.neuronova.com/index.php?option=com_content&task=view&id=41 DMIU0VP DI DMIU0VP DMIU0VP DN SNX-5422 DMIU0VP MI TT78R5H DMIU0VP MN Heat shock protein 90 alpha (HSP90A) DMIU0VP MT DTT DMIU0VP MA Inhibitor DMIU0VP RN SNX-2112, a selective Hsp90 inhibitor, potently inhibits tumor cell growth, angiogenesis, and osteoclastogenesis in multiple myeloma and other hema... Blood. 2009 Jan 22;113(4):846-55. DMIU0VP RU https://pubmed.ncbi.nlm.nih.gov/18948577 DMIU0VP DI DMIU0VP DMIU0VP DN SNX-5422 DMIU0VP MI TTH5YN2 DMIU0VP MN Heat shock protein 90 beta (HSP90B) DMIU0VP MT DTT DMIU0VP MA Inhibitor DMIU0VP RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMIU0VP RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DMXNTR7 DI DMXNTR7 DMXNTR7 DN SOBI003 DMXNTR7 MI TTPJ2SH DMXNTR7 MN N-sulphoglucosamine sulphohydrolase (SGSH) DMXNTR7 MT DTT DMXNTR7 MA Replacement DMXNTR7 RN Clinical pipeline report, company report or official report of Swedish Orphan Biovitrum. DMXNTR7 RU https://www.sobi.com/en/press-releases/fda-accepts-investigational-new-drug-application-and-grants-fast-track-status DMST6A3 DI DMST6A3 DMST6A3 DN Sodium pyruvate DMST6A3 MI TTZHA0O DMST6A3 MN Carbonic anhydrase IV (CA-IV) DMST6A3 MT DTT DMST6A3 MA Inhibitor DMST6A3 RN Carbonic anhydrase inhibitors. Interaction of isozymes I, II, IV, V, and IX with carboxylates. Bioorg Med Chem Lett. 2005 Feb 1;15(3):573-8. DMST6A3 RU https://pubmed.ncbi.nlm.nih.gov/15664815 DMST6A3 DI DMST6A3 DMST6A3 DN Sodium pyruvate DMST6A3 MI TTULV0X DMST6A3 MN Reactive oxygen species (ROS) DMST6A3 MT DTT DMST6A3 MA Antagonist DMST6A3 RN A molecular mechanism of pyruvate protection against cytotoxicity of reactive oxygen species in osteoblasts. Mol Pharmacol. 2006 Sep;70(3):925-35. DMST6A3 RU https://pubmed.ncbi.nlm.nih.gov/16766717 DM3GO0J DI DM3GO0J DM3GO0J DN Sodium taurocholate DM3GO0J MI DT7JELC DM3GO0J MN Apical sodium-dependent bile acid transporter (SLC10A2) DM3GO0J MT DTP DM3GO0J MA Substrate DM3GO0J RN Identification of a region of the ileal-type sodium/bile acid cotransporter interacting with a competitive bile acid transport inhibitor. Biochemistry. 2002 Dec 17;41(50):14916-24. DM3GO0J RU http://www.ncbi.nlm.nih.gov/pubmed/12475240 DM3GO0J DI DM3GO0J DM3GO0J DN Sodium taurocholate DM3GO0J MI DT9NXMV DM3GO0J MN ATP-binding cassette sub-family A member 8 (ABCA8) DM3GO0J MT DTP DM3GO0J MA Substrate DM3GO0J RN Functional analysis of ABCA8, a new drug transporter. Biochem Biophys Res Commun. 2002 Oct 18;298(1):41-5. DM3GO0J RU http://www.ncbi.nlm.nih.gov/pubmed/12379217 DM3GO0J DI DM3GO0J DM3GO0J DN Sodium taurocholate DM3GO0J MI DTJ0EW4 DM3GO0J MN Bile salt export pump (ABCB11) DM3GO0J MT DTP DM3GO0J MA Substrate DM3GO0J RN Bile salt export pump (BSEP/ABCB11) can transport a nonbile acid substrate, pravastatin. J Pharmacol Exp Ther. 2005 Aug;314(2):876-82. DM3GO0J RU http://www.ncbi.nlm.nih.gov/pubmed/15901796 DM3GO0J DI DM3GO0J DM3GO0J DN Sodium taurocholate DM3GO0J MI TTSDVTR DM3GO0J MN G-protein coupled bile acid receptor 1 (GPBAR1) DM3GO0J MT DTT DM3GO0J MA Modulator DM3GO0J RN Bile acids and sphingosine-1-phosphate receptor 2 in hepatic lipid metabolism.Acta Pharmaceutica Sinica B Volume 5, Issue 2, March 2015, Pages 151-157. DM3GO0J RU http://www.sciencedirect.com/science/article/pii/S2211383514001300 DM3GO0J DI DM3GO0J DM3GO0J DN Sodium taurocholate DM3GO0J MI DTFI42L DM3GO0J MN Multidrug resistance-associated protein 2 (ABCC2) DM3GO0J MT DTP DM3GO0J MA Substrate DM3GO0J RN Functional analysis of ABCA8, a new drug transporter. Biochem Biophys Res Commun. 2002 Oct 18;298(1):41-5. DM3GO0J RU http://www.ncbi.nlm.nih.gov/pubmed/12379217 DM3GO0J DI DM3GO0J DM3GO0J DN Sodium taurocholate DM3GO0J MI DTQ3ZHF DM3GO0J MN Multidrug resistance-associated protein 3 (ABCC3) DM3GO0J MT DTP DM3GO0J MA Substrate DM3GO0J RN Characterization of the role of polar amino acid residues within predicted transmembrane helix 17 in determining the substrate specificity of multidrug resistance protein 3. Biochemistry. 2003 Aug 26;42(33):9989-10000. DM3GO0J RU http://www.ncbi.nlm.nih.gov/pubmed/12924948 DM3GO0J DI DM3GO0J DM3GO0J DN Sodium taurocholate DM3GO0J MI DTE2B1D DM3GO0J MN Organic anion transporting polypeptide 1A2 (SLCO1A2) DM3GO0J MT DTP DM3GO0J MA Substrate DM3GO0J RN Molecular and functional characterization of an organic anion transporting polypeptide cloned from human liver. Gastroenterology. 1995 Oct;109(4):1274-82. DM3GO0J RU http://www.ncbi.nlm.nih.gov/pubmed/7557095 DM3GO0J DI DM3GO0J DM3GO0J DN Sodium taurocholate DM3GO0J MI DT3D8F0 DM3GO0J MN Organic anion transporting polypeptide 1B1 (SLCO1B1) DM3GO0J MT DTP DM3GO0J MA Substrate DM3GO0J RN Regulation of Organic Anion Transporting Polypeptides (OATP) 1B1- and OATP1B3-Mediated Transport: An Updated Review in the Context of OATP-Mediated Drug-Drug Interactions. Int J Mol Sci. 2018 Mar 14;19(3). pii: E855. DM3GO0J RU http://www.ncbi.nlm.nih.gov/pubmed/29538325 DM3GO0J DI DM3GO0J DM3GO0J DN Sodium taurocholate DM3GO0J MI DT9C1TS DM3GO0J MN Organic anion transporting polypeptide 1B3 (SLCO1B3) DM3GO0J MT DTP DM3GO0J MA Substrate DM3GO0J RN LST-2, a human liver-specific organic anion transporter, determines methotrexate sensitivity in gastrointestinal cancers. Gastroenterology. 2001 Jun;120(7):1689-99. DM3GO0J RU http://www.ncbi.nlm.nih.gov/pubmed/11375950 DM3GO0J DI DM3GO0J DM3GO0J DN Sodium taurocholate DM3GO0J MI DTPFTEQ DM3GO0J MN Organic anion transporting polypeptide 2B1 (SLCO2B1) DM3GO0J MT DTP DM3GO0J MA Substrate DM3GO0J RN Functional characterization of pH-sensitive organic anion transporting polypeptide OATP-B in human. J Pharmacol Exp Ther. 2004 Feb;308(2):438-45. DM3GO0J RU http://www.ncbi.nlm.nih.gov/pubmed/14610227 DM3GO0J DI DM3GO0J DM3GO0J DN Sodium taurocholate DM3GO0J MI DT1V9AJ DM3GO0J MN Organic solute transporter subunit beta (SLC51B) DM3GO0J MT DTP DM3GO0J MA Substrate DM3GO0J RN OSTalpha-OSTbeta: a major basolateral bile acid and steroid transporter in human intestinal, renal, and biliary epithelia. Hepatology. 2005 Dec;42(6):1270-9. DM3GO0J RU http://www.ncbi.nlm.nih.gov/pubmed/16317684 DM3GO0J DI DM3GO0J DM3GO0J DN Sodium taurocholate DM3GO0J MI DT56EKP DM3GO0J MN Sodium/taurocholate cotransporting polypeptide (SLC10A1) DM3GO0J MT DTP DM3GO0J MA Substrate DM3GO0J RN Differential inhibition of rat and human Na+-dependent taurocholate cotransporting polypeptide (NTCP/SLC10A1)by bosentan: a mechanism for species differences in hepatotoxicity. J Pharmacol Exp Ther. 2007 Jun;321(3):1170-8. DM3GO0J RU http://www.ncbi.nlm.nih.gov/pubmed/17374746 DMEVGI9 DI DMEVGI9 DMEVGI9 DN SPK-7001 DMEVGI9 MI TTOA18V DMEVGI9 MN Rab proteins geranylgeranyltransferase component A 1 (CHM) DMEVGI9 MT DTT DMEVGI9 MA Replacement DMEVGI9 RN Clinical pipeline report, company report or official report of Spark Therapeutics. DMEVGI9 RU https://sparktx.com/scientific-platform-programs/ DM8K7CN DI DM8K7CN DM8K7CN DN SPK-8011 DM8K7CN MI TT1290U DM8K7CN MN Coagulation factor VIII (F8) DM8K7CN MT DTT DM8K7CN MA Replacement DM8K7CN RN Clinical pipeline report, company report or official report of Spark Therapeutics. DM8K7CN RU https://sparktx.com/scientific-platform-programs/ DMCP8F3 DI DMCP8F3 DMCP8F3 DN SPK-8016 DMCP8F3 MI TT1290U DMCP8F3 MN Coagulation factor VIII (F8) DMCP8F3 MT DTT DMCP8F3 MA Replacement DMCP8F3 RN Clinical pipeline report, company report or official report of Spark Therapeutics. DMCP8F3 RU https://sparktx.com/scientific-platform-programs/ DMJDV0K DI DMJDV0K DMJDV0K DN SPR720 DMJDV0K MI TTS7LWX DMJDV0K MN Bacterial DNA gyrase B (Bact gyrB) DMJDV0K MT DTT DMJDV0K MA Inhibitor DMJDV0K RN Advancement of GyrB Inhibitors for Treatment of Infections Caused by Mycobacterium tuberculosis and Non-tuberculous Mycobacteria. ACS Infect Dis. 2020 Jun 12;6(6):1323-1331. DMJDV0K RU https://pubmed.ncbi.nlm.nih.gov/32183511 DMG8JLC DI DMG8JLC DMG8JLC DN SRP-9003 DMG8JLC MI TTEDCQ0 DMG8JLC MN Beta-sarcoglycan (SGCB) DMG8JLC MT DTT DMG8JLC MA Replacement DMG8JLC RN Clinical pipeline report, company report or official report of Sarepta Therapeutics. DMG8JLC RU https://www.sarepta.com/products-pipeline/pipeline DMK095Z DI DMK095Z DMK095Z DN SRP-9004 DMK095Z MI TTS9Q5V DMK095Z MN Sarcoglycan alpha (SGCA) DMK095Z MT DTT DMK095Z MA Replacement DMK095Z RN Clinical pipeline report, company report or official report of Sarepta Therapeutics. DMK095Z RU https://www.sarepta.com/products-pipeline/pipeline DMBCIXL DI DMBCIXL DMBCIXL DN Stamulumab DMBCIXL MI TTSWPH8 DMBCIXL MN Growth/differentiation factor 8 (GDF-8) DMBCIXL MT DTT DMBCIXL RN Myostatin inhibitors as therapies for muscle wasting associated with cancer and other disorders. Curr Opin Support Palliat Care. 2013 November; 7(4): 352-360. DMBCIXL RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3819341/ DMX3CNS DI DMX3CNS DMX3CNS DN Stargen DMX3CNS MI TTLB52K DMX3CNS MN ATP-binding cassette transporter A4 (ABCA4) DMX3CNS MT DTT DMX3CNS MA Modulator DMX3CNS RN Clinical pipeline report, company report or official report of Oxford BioMedica. DMX3CNS RU http://www.oxfordbiomedica.co.uk/press-releases/oxford-biomedica-announces-positive-dsmb-review-of-ongoing-retinostat-r-and-stargen-clinical-studies/ DMZM6I2 DI DMZM6I2 DMZM6I2 DN Sym013 DMZM6I2 MI TTGKNB4 DMZM6I2 MN Epidermal growth factor receptor (EGFR) DMZM6I2 MT DTT DMZM6I2 MA Antagonist DMZM6I2 RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMZM6I2 RU http://phrma-docs.phrma.org/files/dmfile/MID_Immuno-Oncology-2017_Drug-List1.pdf DMZM6I2 DI DMZM6I2 DMZM6I2 DN Sym013 DMZM6I2 MI TT6EO5L DMZM6I2 MN Erbb2 tyrosine kinase receptor (HER2) DMZM6I2 MT DTT DMZM6I2 MA Inhibitor DMZM6I2 RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMZM6I2 RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DMZM6I2 DI DMZM6I2 DMZM6I2 DN Sym013 DMZM6I2 MI TTDC8N2 DMZM6I2 MN Erbb3 tyrosine kinase receptor (Erbb-3) DMZM6I2 MT DTT DMZM6I2 MA Inhibitor DMZM6I2 RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMZM6I2 RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DM9B7Z5 DI DM9B7Z5 DM9B7Z5 DN Sym015 DM9B7Z5 MI TTGKNB4 DM9B7Z5 MN Epidermal growth factor receptor (EGFR) DM9B7Z5 MT DTT DM9B7Z5 MA Antagonist DM9B7Z5 RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DM9B7Z5 RU http://phrma-docs.phrma.org/files/dmfile/MID_Immuno-Oncology-2017_Drug-List1.pdf DM9B7Z5 DI DM9B7Z5 DM9B7Z5 DN Sym015 DM9B7Z5 MI TTNDSF4 DM9B7Z5 MN Proto-oncogene c-Met (MET) DM9B7Z5 MT DTT DM9B7Z5 MA Inhibitor DM9B7Z5 RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DM9B7Z5 RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DMB2NP8 DI DMB2NP8 DMB2NP8 DN T-1249 DMB2NP8 MI TTG90S6 DMB2NP8 MN Human immunodeficiency virus Glycoprotein 41 (HIV gp41) DMB2NP8 MT DTT DMB2NP8 MA Inhibitor DMB2NP8 RN HIV entry inhibitors in clinical development. Curr Opin Pharmacol. 2002 Oct;2(5):523-8. DMB2NP8 RU https://pubmed.ncbi.nlm.nih.gov/12324253 DMWIH59 DI DMWIH59 DMWIH59 DN T2c-003 DMWIH59 MI TTFBNVI DMWIH59 MN Aldose reductase (AKR1B1) DMWIH59 MT DTT DMWIH59 MA Modulator DMWIH59 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2768). DMWIH59 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2768 DM1FY97 DI DM1FY97 DM1FY97 DN T3D-959 DM1FY97 MI TT2JWF6 DM1FY97 MN Peroxisome proliferator-activated receptor delta (PPARD) DM1FY97 MT DTT DM1FY97 MA Modulator DM1FY97 RN Phrma report (2013 Alzheimers disease) DM1FY97 RU http://www.phrma.org/sites/default/files/Alzheimer's%202013.pdf DM1FY97 DI DM1FY97 DM1FY97 DN T3D-959 DM1FY97 MI TTZMAO3 DM1FY97 MN Peroxisome proliferator-activated receptor gamma (PPAR-gamma) DM1FY97 MT DTT DM1FY97 MA Modulator DM1FY97 RN Phrma report (2013 Alzheimers disease) DM1FY97 RU http://www.phrma.org/sites/default/files/Alzheimer's%202013.pdf DMCFSZ5 DI DMCFSZ5 DMCFSZ5 DN TAI-GPC3-CART cells DMCFSZ5 MI TTJTSX4 DMCFSZ5 MN Glypican-3 (GPC3) DMCFSZ5 MT DTT DMCFSZ5 MA CAR-T-Cell-Therapy DMCFSZ5 RN ClinicalTrials.gov (NCT02715362) A Study of GPC3 Redirected Autologous T Cells for Advanced HCC DMCFSZ5 RU https://clinicaltrials.gov/ct2/show/NCT02715362 DMJSQXT DI DMJSQXT DMJSQXT DN TAK-007 DMJSQXT MI TTW640A DMJSQXT MN B-lymphocyte surface antigen B4 (CD19) DMJSQXT MT DTT DMJSQXT RN Clinical pipeline report, company report or official report of Takeda. DMJSQXT RU https://www.takeda.com/newsroom/newsreleases/2020/takeda-opens-new-rd-cell-therapy-manufacturing-facility-to--support-expansion-of-next-generation-clinical-programs/ DM1AB4L DI DM1AB4L DM1AB4L DN Talotrexin DM1AB4L MI TTVC37M DM1AB4L MN Folate receptor alpha (FOLR1) DM1AB4L MT DTT DM1AB4L MA Antagonist DM1AB4L RN Cancer chemotherapy: targeting folic acid synthesis. Cancer Manag Res. 2010; 2: 293-301. DM1AB4L RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3033035/ DM13AH8 DI DM13AH8 DM13AH8 DN TAS-0728 DM13AH8 MI TT6EO5L DM13AH8 MN Erbb2 tyrosine kinase receptor (HER2) DM13AH8 MT DTT DM13AH8 MA Inhibitor DM13AH8 RN TAS0728, A Covalent-binding, HER2-selective Kinase Inhibitor Shows Potent Antitumor Activity in Preclinical Models. Mol Cancer Ther. 2019 Apr;18(4):733-742. DM13AH8 RU https://pubmed.ncbi.nlm.nih.gov/30787176 DM2LZ8F DI DM2LZ8F DM2LZ8F DN Taurocholic acid DM2LZ8F MI DT7JELC DM2LZ8F MN Apical sodium-dependent bile acid transporter (SLC10A2) DM2LZ8F MT DTP DM2LZ8F MA Substrate DM2LZ8F RN Identification of a region of the ileal-type sodium/bile acid cotransporter interacting with a competitive bile acid transport inhibitor. Biochemistry. 2002 Dec 17;41(50):14916-24. DM2LZ8F RU http://www.ncbi.nlm.nih.gov/pubmed/12475240 DM2LZ8F DI DM2LZ8F DM2LZ8F DN Taurocholic acid DM2LZ8F MI DTJ0EW4 DM2LZ8F MN Bile salt export pump (ABCB11) DM2LZ8F MT DTP DM2LZ8F MA Substrate DM2LZ8F RN Inhibition of transport across the hepatocyte canalicular membrane by the antibiotic fusidate. Biochem Pharmacol. 2002 Jul 1;64(1):151-8. DM2LZ8F RU http://www.ncbi.nlm.nih.gov/pubmed/12106615 DM2LZ8F DI DM2LZ8F DM2LZ8F DN Taurocholic acid DM2LZ8F MI TTTRNQW DM2LZ8F MN Bile-salt-activated lipase (CEL) DM2LZ8F MT DTT DM2LZ8F MA Inhibitor DM2LZ8F RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DM2LZ8F RU https://pubmed.ncbi.nlm.nih.gov/17139284 DM2LZ8F DI DM2LZ8F DM2LZ8F DN Taurocholic acid DM2LZ8F MI DTI7UX6 DM2LZ8F MN Breast cancer resistance protein (ABCG2) DM2LZ8F MT DTP DM2LZ8F MA Substrate DM2LZ8F RN Characterization of the role of ABCG2 as a bile acid transporter in liver and placenta. Mol Pharmacol. 2012 Feb;81(2):273-83. DM2LZ8F RU https://doi.org/10.1124/mol.111.075143 DM2LZ8F DI DM2LZ8F DM2LZ8F DN Taurocholic acid DM2LZ8F MI TTPI1M5 DM2LZ8F MN Ileal sodium/bile acid cotransporter (SLC10A2) DM2LZ8F MT DTT DM2LZ8F MA Modulator DM2LZ8F RN Expression and transport properties of the human ileal and renal sodium-dependent bile acid transporter. Am J Physiol. 1998 Jan;274(1 Pt 1):G157-69. DM2LZ8F RU https://pubmed.ncbi.nlm.nih.gov/9458785 DM2LZ8F DI DM2LZ8F DM2LZ8F DN Taurocholic acid DM2LZ8F MI DTQ3ZHF DM2LZ8F MN Multidrug resistance-associated protein 3 (ABCC3) DM2LZ8F MT DTP DM2LZ8F MA Substrate DM2LZ8F RN Characterization of the role of polar amino acid residues within predicted transmembrane helix 17 in determining the substrate specificity of multidrug resistance protein 3. Biochemistry. 2003 Aug 26;42(33):9989-10000. DM2LZ8F RU http://www.ncbi.nlm.nih.gov/pubmed/12924948 DM2LZ8F DI DM2LZ8F DM2LZ8F DN Taurocholic acid DM2LZ8F MI DTCSGPB DM2LZ8F MN Multidrug resistance-associated protein 4 (ABCC4) DM2LZ8F MT DTP DM2LZ8F MA Substrate DM2LZ8F RN Human intestinal transporter database: QSAR modeling and virtual profiling of drug uptake, efflux and interactions. Pharm Res. 2013 Apr;30(4):996-1007. DM2LZ8F RU https://doi.org/10.1007/s11095-012-0935-x DM2LZ8F DI DM2LZ8F DM2LZ8F DN Taurocholic acid DM2LZ8F MI DTE2B1D DM2LZ8F MN Organic anion transporting polypeptide 1A2 (SLCO1A2) DM2LZ8F MT DTP DM2LZ8F MA Substrate DM2LZ8F RN Identification of multiple binding sites for substrate transport in bovine organic anion transporting polypeptide 1a2. Drug Metab Dispos. 2013 Mar;41(3):602-7. DM2LZ8F RU http://www.ncbi.nlm.nih.gov/pubmed/23255551 DM2LZ8F DI DM2LZ8F DM2LZ8F DN Taurocholic acid DM2LZ8F MI DT3D8F0 DM2LZ8F MN Organic anion transporting polypeptide 1B1 (SLCO1B1) DM2LZ8F MT DTP DM2LZ8F MA Substrate DM2LZ8F RN Identification of a novel gene family encoding human liver-specific organic anion transporter LST-1. J Biol Chem. 1999 Jun 11;274(24):17159-63. DM2LZ8F RU http://www.ncbi.nlm.nih.gov/pubmed/10358072 DM2LZ8F DI DM2LZ8F DM2LZ8F DN Taurocholic acid DM2LZ8F MI DT9C1TS DM2LZ8F MN Organic anion transporting polypeptide 1B3 (SLCO1B3) DM2LZ8F MT DTP DM2LZ8F MA Substrate DM2LZ8F RN Effect of pregnane X receptor ligands on transport mediated by human OATP1B1 and OATP1B3. Eur J Pharmacol. 2008 Apr 14;584(1):57-65. DM2LZ8F RU http://www.ncbi.nlm.nih.gov/pubmed/18321482 DM2LZ8F DI DM2LZ8F DM2LZ8F DN Taurocholic acid DM2LZ8F MI DTPFTEQ DM2LZ8F MN Organic anion transporting polypeptide 2B1 (SLCO2B1) DM2LZ8F MT DTP DM2LZ8F MA Substrate DM2LZ8F RN Functional characterization of pH-sensitive organic anion transporting polypeptide OATP-B in human. J Pharmacol Exp Ther. 2004 Feb;308(2):438-45. DM2LZ8F RU http://www.ncbi.nlm.nih.gov/pubmed/14610227 DM2LZ8F DI DM2LZ8F DM2LZ8F DN Taurocholic acid DM2LZ8F MI DT8H2IC DM2LZ8F MN Organic anion transporting polypeptide 4A1 (SLCO4A1) DM2LZ8F MT DTP DM2LZ8F MA Substrate DM2LZ8F RN Identification of thyroid hormone transporters in humans: different molecules are involved in a tissue-specific manner. Endocrinology. 2001 May;142(5):2005-12. DM2LZ8F RU http://www.ncbi.nlm.nih.gov/pubmed/11316767 DM2LZ8F DI DM2LZ8F DM2LZ8F DN Taurocholic acid DM2LZ8F MI DTMEQ32 DM2LZ8F MN Organic solute transporter subunit alpha (SLC51A) DM2LZ8F MT DTP DM2LZ8F MA Substrate DM2LZ8F RN Functional complementation between a novel mammalian polygenic transport complex and an evolutionarily ancient organic solute transporter, OSTalpha-OSTbeta. J Biol Chem. 2003 Jul 25;278(30):27473-82. DM2LZ8F RU http://www.ncbi.nlm.nih.gov/pubmed/12719432 DM2LZ8F DI DM2LZ8F DM2LZ8F DN Taurocholic acid DM2LZ8F MI DT1V9AJ DM2LZ8F MN Organic solute transporter subunit beta (SLC51B) DM2LZ8F MT DTP DM2LZ8F MA Substrate DM2LZ8F RN Functional complementation between a novel mammalian polygenic transport complex and an evolutionarily ancient organic solute transporter, OSTalpha-OSTbeta. J Biol Chem. 2003 Jul 25;278(30):27473-82. DM2LZ8F RU http://www.ncbi.nlm.nih.gov/pubmed/12719432 DM2LZ8F DI DM2LZ8F DM2LZ8F DN Taurocholic acid DM2LZ8F MI DT56EKP DM2LZ8F MN Sodium/taurocholate cotransporting polypeptide (SLC10A1) DM2LZ8F MT DTP DM2LZ8F MA Substrate DM2LZ8F RN Modulation by drugs of human hepatic sodium-dependent bile acid transporter (sodium taurocholate cotransporting polypeptide) activity. J Pharmacol Exp Ther. 1999 Dec;291(3):1204-9. DM2LZ8F RU http://www.ncbi.nlm.nih.gov/pubmed/10565843 DM5NICF DI DM5NICF DM5NICF DN TBI-1501 DM5NICF MI TTW640A DM5NICF MN B-lymphocyte surface antigen B4 (CD19) DM5NICF MT DTT DM5NICF MA CAR-T-Cell-Therapy DM5NICF RN ClinicalTrials.gov (NCT03155191) Study of TBI-1501 for Relapsed or Refractory Acute Lymphoblastic Leukemia DM5NICF RU https://clinicaltrials.gov/ct2/show/NCT03155191 DMR65X7 DI DMR65X7 DMR65X7 DN TC-110 DMR65X7 MI TTW640A DMR65X7 MN B-lymphocyte surface antigen B4 (CD19) DMR65X7 MT DTT DMR65X7 RN Clinical pipeline report, company report or official report of TCR2 Therapeutics. DMR65X7 RU https://www.tcr2.com/hematological-malignancies#tc110 DM9S5I1 DI DM9S5I1 DM9S5I1 DN TC-210 DM9S5I1 MI TT4RXME DM9S5I1 MN Mesothelin (MSLN) DM9S5I1 MT DTT DM9S5I1 RN Clinical pipeline report, company report or official report of TCR2 Therapeutics. DM9S5I1 RU https://www.tcr2.com/solid-tumors#tc210 DMZFIGQ DI DMZFIGQ DMZFIGQ DN TG02 DMZFIGQ MI TTMBO1Z DMZFIGQ MN Cyclin-dependent kinase (CDK) DMZFIGQ MT DTT DMZFIGQ MA Inhibitor DMZFIGQ RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMZFIGQ RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DMZFIGQ DI DMZFIGQ DMZFIGQ DN TG02 DMZFIGQ MI TT7HF4W DMZFIGQ MN Cyclin-dependent kinase 2 (CDK2) DMZFIGQ MT DTT DMZFIGQ MA Modulator DMZFIGQ RN Preclinical metabolism and pharmacokinetics of SB1317 (TG02), a potent CDK/JAK2/FLT3 inhibitor. Drug Metab Lett. 2012 Mar;6(1):33-42. DMZFIGQ RU https://pubmed.ncbi.nlm.nih.gov/22372550 DMZFIGQ DI DMZFIGQ DMZFIGQ DN TG02 DMZFIGQ MI DEJGDUW DMZFIGQ MN Cytochrome P450 1A2 (CYP1A2) DMZFIGQ MT DME DMZFIGQ MA Metabolism DMZFIGQ RN Preclinical metabolism and pharmacokinetics of SB1317 (TG02), a potent CDK/JAK2/FLT3 inhibitor. Drug Metab Lett. 2012 Mar;6(1):33-42. DMZFIGQ RU https://www.ncbi.nlm.nih.gov/pubmed/?term=22372550 DMZFIGQ DI DMZFIGQ DMZFIGQ DN TG02 DMZFIGQ MI DE4LYSA DMZFIGQ MN Cytochrome P450 3A4 (CYP3A4) DMZFIGQ MT DME DMZFIGQ MA Metabolism DMZFIGQ RN Preclinical metabolism and pharmacokinetics of SB1317 (TG02), a potent CDK/JAK2/FLT3 inhibitor. Drug Metab Lett. 2012 Mar;6(1):33-42. DMZFIGQ RU https://www.ncbi.nlm.nih.gov/pubmed/?term=22372550 DMZFIGQ DI DMZFIGQ DMZFIGQ DN TG02 DMZFIGQ MI TTU8W4S DMZFIGQ MN Protein kinase (PK) DMZFIGQ MT DTT DMZFIGQ MA Inhibitor DMZFIGQ RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMZFIGQ RU http://phrma-docs.phrma.org/files/dmfile/MID_Neurological-Disorders-Drug-List_2018.pdf DMON4IL DI DMON4IL DMON4IL DN TG100-115 DMON4IL MI TTHBTOP DMON4IL MN PI3-kinase gamma (PIK3CG) DMON4IL MT DTT DMON4IL MA Inhibitor DMON4IL RN Aerosolized phosphoinositide 3-kinase gamma/delta inhibitor TG100-115 [3-[2,4-diamino-6-(3-hydroxyphenyl)pteridin-7-yl]phenol] as a therapeutic can... J Pharmacol Exp Ther. 2009 Mar;328(3):758-65. DMON4IL RU https://pubmed.ncbi.nlm.nih.gov/19056934 DMNKLZM DI DMNKLZM DMNKLZM DN TgAAG76 DMNKLZM MI TTBOH16 DMNKLZM MN Retinal pigment epithelium protein (RPE65) DMNKLZM MT DTT DMNKLZM MA Modulator DMNKLZM RN tgAAG76, an adeno-associated virus delivered gene therapy for the potential treatment of vision loss caused by RPE65 gene abnormalities. Curr Opin Mol Ther. 2010 Aug;12(4):471-7. DMNKLZM RU https://pubmed.ncbi.nlm.nih.gov/20677098 DMDJLX7 DI DMDJLX7 DMDJLX7 DN Timcodar dimesilate DMDJLX7 MI TTFH2RS DMDJLX7 MN FK506-binding protein (FKBP) DMDJLX7 MT DTT DMDJLX7 MA Modulator DMDJLX7 RN Analysis of FK506, timcodar (VX-853) and FKBP51 and FKBP52 chaperones in control of glucocorticoid receptor activity and phosphorylation. Pharmacol Res Perspect. 2014 December; 2(6): e00076. DMDJLX7 RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4186452/ DM0VXIM DI DM0VXIM DM0VXIM DN TJ003234 DM0VXIM MI TTPZGYX DM0VXIM MN HUMAN colony-stimulating factor (GM-CSF) DM0VXIM MT DTT DM0VXIM MA Inhibitor DM0VXIM RN The anti-viral facet of anti-rheumatic drugs: Lessons from COVID-19. J Autoimmun. 2020 Apr 17:102468. DM0VXIM RU https://pubmed.ncbi.nlm.nih.gov/32317220 DMLROMP DI DMLROMP DMLROMP DN TKM-PLK1 DMLROMP MI TTH4IP0 DMLROMP MN PLK1 messenger RNA (PLK1 mRNA) DMLROMP MT DTT DMLROMP RN Clinical pipeline report, company report or official report of Arbutus Biopharma. DMLROMP RU http://arbutusbio.com/portfolio/tkm-plk1.php DM6AXV9 DI DM6AXV9 DM6AXV9 DN TOL-101 DM6AXV9 MI TT7AKW1 DM6AXV9 MN T-cell receptor (TCR) DM6AXV9 MT DTT DM6AXV9 RN First-in-Human Study of the Safety and Efficacy of TOL101 Induction to Prevent Kidney Transplant Rejection. Am J Transplant. 2014 June; 14(6): 1346-1355. DM6AXV9 RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4404309/ DMHTG8P DI DMHTG8P DMHTG8P DN TP-0903 DMHTG8P MI TTZPY6J DMHTG8P MN Tyrosine-protein kinase UFO (AXL) DMHTG8P MT DTT DMHTG8P MA Inhibitor DMHTG8P RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMHTG8P RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DM9FB2T DI DM9FB2T DM9FB2T DN TPX-0005 DM9FB2T MI TTPMQSO DM9FB2T MN ALK tyrosine kinase receptor (ALK) DM9FB2T MT DTT DM9FB2T MA Inhibitor DM9FB2T RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DM9FB2T RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DM9FB2T DI DM9FB2T DM9FB2T DN TPX-0005 DM9FB2T MI TTSZ6Y3 DM9FB2T MN Proto-oncogene c-Ros (ROS1) DM9FB2T MT DTT DM9FB2T MA Inhibitor DM9FB2T RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DM9FB2T RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DM9FB2T DI DM9FB2T DM9FB2T DN TPX-0005 DM9FB2T MI TTTDVOJ DM9FB2T MN Tropomyosin-related kinase A (TrkA) DM9FB2T MT DTT DM9FB2T MA Inhibitor DM9FB2T RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DM9FB2T RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DMIVE67 DI DMIVE67 DMIVE67 DN TPX-0046 DMIVE67 MI TT4DXQT DMIVE67 MN Proto-oncogene c-Ret (RET) DMIVE67 MT DTT DMIVE67 MA Inhibitor DMIVE67 RN Clinical pipeline report, company report or official report of Turning Point Therapeutics. DMIVE67 RU https://tptherapeutics.com/pipeline/tpx-0046/ DMIVE67 DI DMIVE67 DMIVE67 DN TPX-0046 DMIVE67 MI TT6PKBN DMIVE67 MN Proto-oncogene c-Src (SRC) DMIVE67 MT DTT DMIVE67 MA Inhibitor DMIVE67 RN Clinical pipeline report, company report or official report of Turning Point Therapeutics. DMIVE67 RU https://tptherapeutics.com/pipeline/tpx-0046/ DM8D2LC DI DM8D2LC DM8D2LC DN Tractinostat DM8D2LC MI TTBH0VX DM8D2LC MN Histone deacetylase (HDAC) DM8D2LC MT DTT DM8D2LC MA Inhibitor DM8D2LC RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DM8D2LC RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DM1ZK4W DI DM1ZK4W DM1ZK4W DN TRBC1 DM1ZK4W MI TT1DHW2 DM1ZK4W MN T-cell receptor beta constant 1 (TRBC1) DM1ZK4W MT DTT DM1ZK4W MA CAR-T-Cell-Therapy DM1ZK4W RN ClinicalTrials.gov (NCT03590574) Phase I/II Study Evaluating AUTO4 in Patients With TRBC1 Positive T Cell Lymphoma DM1ZK4W RU https://clinicaltrials.gov/ct2/show/NCT03590574 DMXI8CD DI DMXI8CD DMXI8CD DN TRC-253 DMXI8CD MI TTKPW01 DMXI8CD MN Androgen receptor messenger RNA (AR mRNA) DMXI8CD MT DTT DMXI8CD MA Antagonist DMXI8CD RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMXI8CD RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DML54PD DI DML54PD DML54PD DN TriCAR-T-CD19 DML54PD MI TTW640A DML54PD MN B-lymphocyte surface antigen B4 (CD19) DML54PD MT DTT DML54PD MA CAR-T-Cell-Therapy DML54PD RN ClinicalTrials.gov (NCT03497533) Treatment of Refractory/Relapsed Non-Hodgkin Lymphoma With TriCAR-T_CD19 DML54PD RU https://clinicaltrials.gov/ct2/show/NCT03497533 DM8IC5H DI DM8IC5H DM8IC5H DN Triciribine DM8IC5H MI DE7T5VX DM8IC5H MN Adenosine kinase (ADK) DM8IC5H MT DME DM8IC5H MA Metabolism DM8IC5H RN Phosphorylation of triciribine is necessary for activity against HIV type 1. AIDS Res Hum Retroviruses. 1998 Oct 10;14(15):1315-22. DM8IC5H RU https://www.ncbi.nlm.nih.gov/pubmed/?term=9788672 DM8IC5H DI DM8IC5H DM8IC5H DN Triciribine DM8IC5H MI TT84ETX DM8IC5H MN Human immunodeficiency virus Reverse transcriptase (HIV RT) DM8IC5H MT DTT DM8IC5H MA Inhibitor DM8IC5H RN Design, synthesis and antiviral activity of novel 4,5-disubstituted 7-(beta-D-ribofuranosyl)pyrrolo[2,3-d][1,2,3]triazines and the novel 3-amino-5-... J Med Chem. 2005 Jun 2;48(11):3840-51. DM8IC5H RU https://pubmed.ncbi.nlm.nih.gov/15916436 DMBN1XS DI DMBN1XS DMBN1XS DN Triciribine prodrug DMBN1XS MI TTWTSCV DMBN1XS MN RAC-alpha serine/threonine-protein kinase (AKT1) DMBN1XS MT DTT DMBN1XS MA Inhibitor DMBN1XS RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1479). DMBN1XS RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1479 DM9IQ4A DI DM9IQ4A DM9IQ4A DN TRU-016 DM9IQ4A MI TTFCW29 DM9IQ4A MN Leukocyte antigen CD37 (CD37) DM9IQ4A MT DTT DM9IQ4A MA Modulator DM9IQ4A RN TRU-016, a humanized anti-CD37 IgG fusion protein for the potential treatment of B-cell malignancies. Curr Opin Investig Drugs. 2009 Dec;10(12):1383-90. DM9IQ4A RU https://pubmed.ncbi.nlm.nih.gov/19943209 DMQS5DY DI DMQS5DY DMQS5DY DN TRX-518 DMQS5DY MI TTG6LA7 DMQS5DY MN Activation-inducible TNFR family receptor (TNFRSF18) DMQS5DY MT DTT DMQS5DY RN Immuno-oncology moves beyond PD-1. Nat Biotechnol. 2015 Jul;33(7):673-5. DMQS5DY RU https://pubmed.ncbi.nlm.nih.gov/26153987 DMFOR9Y DI DMFOR9Y DMFOR9Y DN TSR-011 DMFOR9Y MI TTPMQSO DMFOR9Y MN ALK tyrosine kinase receptor (ALK) DMFOR9Y MT DTT DMFOR9Y MA Inhibitor DMFOR9Y RN Treatment of ALK-positive non-small cell lung cancer. Arch Pathol Lab Med. 2012 Oct;136(10):1201-4. DMFOR9Y RU https://pubmed.ncbi.nlm.nih.gov/23020724 DMH9RGV DI DMH9RGV DMH9RGV DN TTP-814 DMH9RGV MI TTMS7KP DMH9RGV MN Protein-tyrosine phosphatase 1B (PTP1B) DMH9RGV MT DTT DMH9RGV MA Inhibitor DMH9RGV RN Protein tyrosine phosphatase 1B (PTP-1B; PTPN1). SciBX 5(7); doi:10.1038/scibx.2012.176. Feb. 16 2012 DMH9RGV RU http://www.nature.com/scibx/journal/v5/n7/full/scibx.2012.176.html DMRJK26 DI DMRJK26 DMRJK26 DN UCART019 DMRJK26 MI TTW640A DMRJK26 MN B-lymphocyte surface antigen B4 (CD19) DMRJK26 MT DTT DMRJK26 MA CAR-T-Cell-Therapy DMRJK26 RN ClinicalTrials.gov (NCT03166878) A Study Evaluating UCART019 in Patients With Relapsed or Refractory CD19+ Leukemia and Lymphoma DMRJK26 RU https://clinicaltrials.gov/ct2/show/NCT03166878 DMI0H3B DI DMI0H3B DMI0H3B DN UshStat DMI0H3B MI TTNIMDP DMI0H3B MN Myosin-7 (MYH7) DMI0H3B MT DTT DMI0H3B MA Modulator DMI0H3B RN EIAV-based retinal gene therapy in the shaker1 mouse model for usher syndrome type 1B: development of UshStat. PLoS One. 2014 Apr 4;9(4):e94272. DMI0H3B RU https://pubmed.ncbi.nlm.nih.gov/24705452 DM6HPEC DI DM6HPEC DM6HPEC DN USL311 DM6HPEC MI TTBID49 DM6HPEC MN C-X-C chemokine receptor type 4 (CXCR4) DM6HPEC MT DTT DM6HPEC MA Antagonist DM6HPEC RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DM6HPEC RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DMPWHU6 DI DMPWHU6 DMPWHU6 DN V81444 DMPWHU6 MI TTM2AOE DMPWHU6 MN Adenosine A2a receptor (ADORA2A) DMPWHU6 MT DTT DMPWHU6 MA Antagonist DMPWHU6 RN Adenosine A2A receptor antagonists in Parkinson's disease: progress in clinical trials from the newly approved istradefylline to drugs in early development and those already discontinued. CNS Drugs. 2014 May;28(5):455-74. DMPWHU6 RU https://pubmed.ncbi.nlm.nih.gov/24687255 DM8A5E0 DI DM8A5E0 DM8A5E0 DN Vecabrutinib DM8A5E0 MI TTGM6VW DM8A5E0 MN Tyrosine-protein kinase BTK (ATK) DM8A5E0 MT DTT DM8A5E0 MA Inhibitor DM8A5E0 RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DM8A5E0 RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DMAN21O DI DMAN21O DMAN21O DN VG-101 DMAN21O MI TTOM3J0 DMAN21O MN Estrogen receptor beta (ESR2) DMAN21O MT DTT DMAN21O MA Agonist DMAN21O RN Update on alternative therapies for vulvovaginal atrophy. Patient Prefer Adherence. 2011; 5: 533-536. DMAN21O RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3218114/ DMAMIU4 DI DMAMIU4 DMAMIU4 DN VIR-201 DMAMIU4 MI TT93WF5 DMAMIU4 MN Interferon-gamma (IFNG) DMAMIU4 MT DTT DMAMIU4 MA Modulator DMAMIU4 RN EP patent application no. 17782511, Nucleoside phosphonate conjugates as anti hiv agents. DMAMIU4 RU http://www.google.com.ar/patents/EP1778251B1?cl=en DMN62MP DI DMN62MP DMN62MP DN WASP gene therapy DMN62MP MI TTE8T73 DMN62MP MN Wiskott-Aldrich syndrome protein (WAS) DMN62MP MT DTT DMN62MP MA Modulator DMN62MP RN ClinicalTrials.gov (NCT01347242) Gene Therapy for Wiskott-Aldrich Syndrome (WAS). U.S. National Institutes of Health. DMN62MP RU https://clinicaltrials.gov/ct2/show/NCT01347242 DMUGHWR DI DMUGHWR DMUGHWR DN WP-1066 DMUGHWR MI TTKAWRQ DMUGHWR MN JAK-STAT signaling pathway (JAK-STAT pathway) DMUGHWR MT DTT DMUGHWR MA Inhibitor DMUGHWR RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7972). DMUGHWR RU http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=7972 DMUGHWR DI DMUGHWR DMUGHWR DN WP-1066 DMUGHWR MI TTH8FZW DMUGHWR MN Signal transducer and activator of transcription 3 (STAT3) DMUGHWR MT DTT DMUGHWR MA Inhibitor DMUGHWR RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMUGHWR RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DM3FIMD DI DM3FIMD DM3FIMD DN WT-4869 DM3FIMD MI TTZ8UT4 DM3FIMD MN Wilms tumor protein (WT1) DM3FIMD MT DTT DM3FIMD MA Modulator DM3FIMD RN Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800033385) DM3FIMD RU http://adisinsight.springer.com/drugs/800033385 DMRABOS DI DMRABOS DMRABOS DN WX-554 DMRABOS MI TTROQ37 DMRABOS MN MAPK/ERK kinase kinase (MAP3K) DMRABOS MT DTT DMRABOS MA Modulator DMRABOS RN MEK and the inhibitors: from bench to bedside. J Hematol Oncol. 2013; 6: 27. DMRABOS RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3626705/ DMZ9VCF DI DMZ9VCF DMZ9VCF DN X-396 DMZ9VCF MI TTPMQSO DMZ9VCF MN ALK tyrosine kinase receptor (ALK) DMZ9VCF MT DTT DMZ9VCF MA Inhibitor DMZ9VCF RN Clinical pipeline report, company report or official report of Xcovery. DMZ9VCF RU http://www.xcovery.com/our-science/alk-inhibitor/ DMU6TG7 DI DMU6TG7 DMU6TG7 DN XMT-1592 DMU6TG7 MI TTQPZTM DMU6TG7 MN Sodium/phosphate cotransporter 2B (SLC34A2) DMU6TG7 MT DTT DMU6TG7 RN Clinical pipeline report, company report or official report of Mersana Therapeutics. DMU6TG7 RU https://www.mersana.com/pipeline/xmt-1592/ DM148HX DI DM148HX DM148HX DN XToll DM148HX MI TTWYMFE DM148HX MN Mitochondrial 10kDa heat shock protein (HSPE1) DM148HX MT DTT DM148HX MA Modulator DM148HX RN XToll, a recombinant chaperonin 10 as an anti-inflammatory immunomodulator. Curr Opin Investig Drugs. 2008 May;9(5):523-33. DM148HX RU https://pubmed.ncbi.nlm.nih.gov/18465663 DMXSEHF DI DMXSEHF DMXSEHF DN Y-39983 DMXSEHF MI TTMQO60 DMXSEHF MN Rho-associated protein kinase (ROCK) DMXSEHF MT DTT DMXSEHF MA Modulator DMXSEHF RN Effects of Y-39983, a selective Rho-associated protein kinase inhibitor, on blood flow in optic nerve head in rabbits and axonal regeneration of retinal ganglion cells in rats.Curr Eye Res. 2011 Oct;36(10):964-70. DMXSEHF RU https://www.ncbi.nlm.nih.gov/pubmed/21950703 DMIA9JD DI DMIA9JD DMIA9JD DN YSCMA DMIA9JD MI TTDIGC1 DMIA9JD MN Dipeptidyl peptidase 4 (DPP-4) DMIA9JD MT DTT DMIA9JD RN Establishment of monoclonal anti-human CD26 antibodies suitable for immunostaining of formalin-fixed tissue. Diagn Pathol. 2014 Feb 6;9:30. DMIA9JD RU https://pubmed.ncbi.nlm.nih.gov/24502396 DMMQGPE DI DMMQGPE DMMQGPE DN Zenocutuzomab DMMQGPE MI TT6EO5L DMMQGPE MN Erbb2 tyrosine kinase receptor (HER2) DMMQGPE MT DTT DMMQGPE MA Inhibitor DMMQGPE RN Clinical pipeline report, company report or official report of Merus. DMMQGPE RU https://merus.nl/pipeline/ DMMQGPE DI DMMQGPE DMMQGPE DN Zenocutuzomab DMMQGPE MI TTDC8N2 DMMQGPE MN Erbb3 tyrosine kinase receptor (Erbb-3) DMMQGPE MT DTT DMMQGPE MA Inhibitor DMMQGPE RN Clinical pipeline report, company report or official report of Merus. DMMQGPE RU https://merus.nl/pipeline/ DMDJSOH DI DMDJSOH DMDJSOH DN ZK-001 DMDJSOH MI TTVB0Q9 DMDJSOH MN Platelet glycoprotein Ib alpha (CD42b) DMDJSOH MT DTT DMDJSOH MA Modulator DMDJSOH RN Anfibatide, a novel GPIb complex antagonist, inhibits platelet adhesion and thrombus formation in vitro and in vivo in murine models of thrombosis. Thromb Haemost. 2014 Feb;111(2):279-89. DMDJSOH RU https://pubmed.ncbi.nlm.nih.gov/24172860 DMVG4OC DI DMVG4OC DMVG4OC DN ZN-c5 DMVG4OC MI TTZAYWL DMVG4OC MN Estrogen receptor (ESR) DMVG4OC MT DTT DMVG4OC MA Degrader DMVG4OC RN Clinical pipeline report, company report or official report of Zentalis Pharmaceuticals. DMVG4OC RU https://zentalis.com/our-pipeline/pipeline/ DMLV4U1 DI DMLV4U1 DMLV4U1 DN ZN-e4 DMLV4U1 MI TTGKNB4 DMLV4U1 MN Epidermal growth factor receptor (EGFR) DMLV4U1 MT DTT DMLV4U1 MA Inhibitor DMLV4U1 RN Clinical pipeline report, company report or official report of Zentalis Pharmaceuticals. DMLV4U1 RU https://zentalis.com/our-pipeline/pipeline/ DMPZE2G DI DMPZE2G DMPZE2G DN ZPL521 DMPZE2G MI TTT1JVS DMPZE2G MN Cytosolic phospholipase A2 (GIVA cPLA2) DMPZE2G MT DTT DMPZE2G MA Inhibitor DMPZE2G RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMPZE2G RU http://phrma-docs.phrma.org/files/dmfile/MID_Skin_Diseases_2018_9_FINAL.pdf DM459Q7 DI DM459Q7 DM459Q7 DN BMS-833923 DM459Q7 MI TT8J1S3 DM459Q7 MN Smoothened homolog (SMO) DM459Q7 MT DTT DM459Q7 MA Inhibitor DM459Q7 RN Clinical pipeline report, company report or official report of Exelixis (2011). DM459Q7 RU http://www.exelixis.com/pipeline DMNCOE1 DI DMNCOE1 DMNCOE1 DN FRM-6308 DMNCOE1 MI TTJW4LU DMNCOE1 MN Phosphodiesterase 10A (PDE10) DMNCOE1 MT DTT DMNCOE1 MA Inhibitor DMNCOE1 RN Massive schizophrenia genomics study offers new drug directions. Nat Rev Drug Discov. 2014 Sep;13(9):641-2. DMNCOE1 RU https://pubmed.ncbi.nlm.nih.gov/25131831 DMVWYOU DI DMVWYOU DMVWYOU DN GGF DMVWYOU MI TTEH395 DMVWYOU MN Pro-neuregulin-1 (Pro-NRG1) DMVWYOU MT DTT DMVWYOU MA Modulator DMVWYOU RN Glial growth factor/neuregulin inhibits Schwann cell myelination and induces demyelination. J Cell Biol. 2001 Mar 19;152(6):1289-99. DMVWYOU RU https://pubmed.ncbi.nlm.nih.gov/11257128 DMQGH76 DI DMQGH76 DMQGH76 DN S-222611 DMQGH76 MI TTGKNB4 DMQGH76 MN Epidermal growth factor receptor (EGFR) DMQGH76 MT DTT DMQGH76 MA Inhibitor DMQGH76 RN Clinical pipeline report, company report or official report of Shionogi (2011). DMQGH76 RU http://www.shionogi.co.jp/index_e.html DMQGH76 DI DMQGH76 DMQGH76 DN S-222611 DMQGH76 MI TT6EO5L DMQGH76 MN Erbb2 tyrosine kinase receptor (HER2) DMQGH76 MT DTT DMQGH76 MA Inhibitor DMQGH76 RN Clinical pipeline report, company report or official report of Shionogi (2011). DMQGH76 RU http://www.shionogi.co.jp/index_e.html DMG74BY DI DMG74BY DMG74BY DN (-)-3PPP, Maryland DMG74BY MI TTEX248 DMG74BY MN Dopamine D2 receptor (D2R) DMG74BY MT DTT DMG74BY MA Agonist DMG74BY RN The pipeline and future of drug development in schizophrenia. Mol Psychiatry. 2007 Oct;12(10):904-22. DMG74BY RU https://pubmed.ncbi.nlm.nih.gov/17667958 DM1CZSJ DI DM1CZSJ DM1CZSJ DN (+)-JQ1 DM1CZSJ MI TTE4BSY DM1CZSJ MN Bromodomain and extraterminal domain protein (BET) DM1CZSJ MT DTT DM1CZSJ MA Inhibitor DM1CZSJ RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DM1CZSJ RU http://phrma-docs.phrma.org/sites/default/files/pdf/medicines-in-development-drug-list-rare-diseases.pdf DM1CZSJ DI DM1CZSJ DM1CZSJ DN (+)-JQ1 DM1CZSJ MI TT7CPI5 DM1CZSJ MN Bromodomain testis-specific protein (BRDT) DM1CZSJ MT DTT DM1CZSJ MA Inhibitor DM1CZSJ RN Small-molecule inhibition of BRDT for male contraception. Cell. 2012 Aug 17;150(4):673-84. DM1CZSJ RU https://pubmed.ncbi.nlm.nih.gov/22901802 DM1CZSJ DI DM1CZSJ DM1CZSJ DN (+)-JQ1 DM1CZSJ MI TTRA6BO DM1CZSJ MN Bromodomain-containing protein 4 (BRD4) DM1CZSJ MT DTT DM1CZSJ MA Inhibitor DM1CZSJ RN Selective inhibition of BET bromodomains. Nature. 2010 Dec 23;468(7327):1067-73. DM1CZSJ RU https://pubmed.ncbi.nlm.nih.gov/20871596 DMBOXA1 DI DMBOXA1 DMBOXA1 DN [3H]fenobam DMBOXA1 MI TTHS256 DMBOXA1 MN Metabotropic glutamate receptor 5 (mGluR5) DMBOXA1 MT DTT DMBOXA1 MA Modulator (allosteric modulator) DMBOXA1 RN Fenobam: a clinically validated nonbenzodiazepine anxiolytic is a potent, selective, and noncompetitive mGlu5 receptor antagonist with inverse agon... J Pharmacol Exp Ther. 2005 Nov;315(2):711-21. DMBOXA1 RU https://pubmed.ncbi.nlm.nih.gov/16040814 DMSCV02 DI DMSCV02 DMSCV02 DN [N-methyl-3H(3)]AZ-10419369 DMSCV02 MI TTK8CXU DMSCV02 MN 5-HT 1B receptor (HTR1B) DMSCV02 MT DTT DMSCV02 MA Antagonist DMSCV02 RN 5-HT1B and other related serotonergic proteins are altered in APPswe mutation. Neurosci Lett. 2015 May 6;594:137-43. DMSCV02 RU https://pubmed.ncbi.nlm.nih.gov/25841787 DMSMRC1 DI DMSMRC1 DMSMRC1 DN 1069C DMSMRC1 MI TTYFKSZ DMSMRC1 MN Tubulin beta (TUBB) DMSMRC1 MT DTT DMSMRC1 MA Modulator DMSMRC1 RN Patent WO2005108424 A1. DMSMRC1 RU http://www.google.com/patents/WO2005108424A1?cl=en DM5IPHE DI DM5IPHE DM5IPHE DN 1192U90 DM5IPHE MI TTSQIFT DM5IPHE MN 5-HT 1A receptor (HTR1A) DM5IPHE MT DTT DM5IPHE MA Agonist DM5IPHE RN The pipeline and future of drug development in schizophrenia. Mol Psychiatry. 2007 Oct;12(10):904-22. DM5IPHE RU https://pubmed.ncbi.nlm.nih.gov/17667958 DM5IPHE DI DM5IPHE DM5IPHE DN 1192U90 DM5IPHE MI TTJQOD7 DM5IPHE MN 5-HT 2A receptor (HTR2A) DM5IPHE MT DTT DM5IPHE MA Antagonist DM5IPHE RN The pipeline and future of drug development in schizophrenia. Mol Psychiatry. 2007 Oct;12(10):904-22. DM5IPHE RU https://pubmed.ncbi.nlm.nih.gov/17667958 DM5IPHE DI DM5IPHE DM5IPHE DN 1192U90 DM5IPHE MI TTEX248 DM5IPHE MN Dopamine D2 receptor (D2R) DM5IPHE MT DTT DM5IPHE MA Antagonist DM5IPHE RN The pipeline and future of drug development in schizophrenia. Mol Psychiatry. 2007 Oct;12(10):904-22. DM5IPHE RU https://pubmed.ncbi.nlm.nih.gov/17667958 DMICUPT DI DMICUPT DMICUPT DN 11C-6-Me-BTA-1 DMICUPT MI TTE4KHA DMICUPT MN Amyloid beta A4 protein (APP) DMICUPT MT DTT DMICUPT MA Modulator DMICUPT RN Radiosynthesis and evaluation of [11C]BTA-1 and [11C]3'-Me-BTA-1 as potential radiotracers for in vivo imaging of beta-amyloid plaques. Nuklearmedizin. 2007;46(6):271-80. DMICUPT RU https://pubmed.ncbi.nlm.nih.gov/18084683 DMYVDXW DI DMYVDXW DMYVDXW DN 11C-AZD-2184 DMYVDXW MI TTE4KHA DMYVDXW MN Amyloid beta A4 protein (APP) DMYVDXW MT DTT DMYVDXW MA Binder DMYVDXW RN Low background and high contrast PET imaging of amyloid-beta with [11C]AZD2995 and [11C]AZD2184 in Alzheimer's disease patients. Eur J Nucl Med Mol Imaging. 2013 April; 40(4): 580-593. DMYVDXW RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3590405/ DMQ0RXA DI DMQ0RXA DMQ0RXA DN 11C-GSK-215083 DMQ0RXA MI TTJS8PY DMQ0RXA MN 5-HT 6 receptor (HTR6) DMQ0RXA MT DTT DMQ0RXA MA Antagonist DMQ0RXA RN Radiosynthesis and characterization of 11C-GSK215083 as a PET radioligand for the 5-HT6 receptor. J Nucl Med. 2012 Feb;53(2):295-303. DMQ0RXA RU https://pubmed.ncbi.nlm.nih.gov/22223878 DMCFPX8 DI DMCFPX8 DMCFPX8 DN 123-Iodine-labeled MFE-23 DMCFPX8 MI TTY6DTE DMCFPX8 MN Carcinoembryonic antigen CEA (CD66e) DMCFPX8 MT DTT DMCFPX8 RN Crystal structure of the anti-(carcinoembryonic antigen) single-chain Fv antibody MFE-23 and a model for antigen binding based on intermolecular contacts.. Biochem J. 2000 March 1; 346(Pt 2): 519-528. DMCFPX8 RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1220881/ DM5ZC0E DI DM5ZC0E DM5ZC0E DN 124I-8H9 DM5ZC0E MI TT6CQUM DM5ZC0E MN B7 homolog 3 (CD276) DM5ZC0E MT DTT DM5ZC0E RN National Cancer Institute Drug Dictionary (drug id 722029). DM5ZC0E RU http://www.cancer.gov/publications/dictionaries/cancer-drug?cdrid=722029 DMD751X DI DMD751X DMD751X DN 1614235 + 2330672 DMD751X MI TTPI1M5 DMD751X MN Ileal sodium/bile acid cotransporter (SLC10A2) DMD751X MT DTT DMD751X MA Modulator DMD751X RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 960). DMD751X RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=960 DMD751X DI DMD751X DMD751X DN 1614235 + 2330672 DMD751X MI TT2UE56 DMD751X MN Sodium/glucose cotransporter 1 (SGLT1) DMD751X MT DTT DMD751X MA Modulator DMD751X RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 915). DMD751X RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=915 DMFG1YA DI DMFG1YA DMFG1YA DN 177Lu-AMBA DMFG1YA MI TTC1MVT DMFG1YA MN Gastrin-releasing peptide receptor (GRPR) DMFG1YA MT DTT DMFG1YA MA Agonist DMFG1YA RN Multimodality imaging and preclinical evaluation of 177Lu-AMBA for human prostate tumours in a murine model. Anticancer Res. 2010 Oct;30(10):4039-48. DMFG1YA RU https://pubmed.ncbi.nlm.nih.gov/21036718 DMM2V74 DI DMM2V74 DMM2V74 DN 177Lu-labelled CTT-1403 DMM2V74 MI TT9G4N0 DMM2V74 MN Glutamate carboxypeptidase II (GCPII) DMM2V74 MT DTT DMM2V74 RN Clinical pipeline report, company report or official report of Cancer Targeted Technologies. DMM2V74 RU https://www.cancertargetedtechnology.com/pipeline/ctt1403/ DMZ5YMX DI DMZ5YMX DMZ5YMX DN 18F-FEDAA-1106 DMZ5YMX MI TTPTXIN DMZ5YMX MN Translocator protein (TSPO) DMZ5YMX MT DTT DMZ5YMX MA Modulator DMZ5YMX RN Role of peripheral benzodiazepine receptors in mitochondrial, cellular, and cardiac damage induced by oxidative stress and ischemia-reperfusion. J Pharmacol Exp Ther. 2003 Sep;306(3):828-37. DMZ5YMX RU https://pubmed.ncbi.nlm.nih.gov/12928523 DMGE3DY DI DMGE3DY DMGE3DY DN 18-MC DMGE3DY MI TT35UGH DMGE3DY MN Neuronal acetylcholine receptor alpha-3/beta-4 (CHRNA3/B4) DMGE3DY MT DTT DMGE3DY MA Antagonist DMGE3DY RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMGE3DY RU http://phrma-docs.phrma.org/files/dmfile/MID_Mental-Illness-2017-Drug-List_Final.pdf DMJ1SQY DI DMJ1SQY DMJ1SQY DN 19-28z T CELLS DMJ1SQY MI TTW640A DMJ1SQY MN B-lymphocyte surface antigen B4 (CD19) DMJ1SQY MT DTT DMJ1SQY MA CAR-T-Cell-Therapy DMJ1SQY RN ClinicalTrials.gov (NCT01840566) High Dose Therapy and Autologous Stem Cell Transplantation Followed by Infusion of Chimeric Antigen Receptor (CAR) Modified T-Cells Directed Against CD19+ B-Cells for Relapsed and Refractory Aggressive B Cell Non-Hodgkin Lymphoma DMJ1SQY RU https://clinicaltrials.gov/ct2/show/NCT01840566 DMQ8NTZ DI DMQ8NTZ DMQ8NTZ DN 192C86 DMQ8NTZ MI TTNVEIR DMQ8NTZ MN Prostaglandin D2 receptor (PTGDR) DMQ8NTZ MT DTT DMQ8NTZ MA Modulator DMQ8NTZ RN Prostanoid receptor antagonists: development strategies and therapeutic applications. Br J Pharmacol. 2009 September; 158(1): 104-145. DMQ8NTZ RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2795261/ DMN9MPX DI DMN9MPX DMN9MPX DN 212Pb-labelled DOTAMTATE DMN9MPX MI TTOMNR9 DMN9MPX MN Somatostatin receptor (SSTR) DMN9MPX MT DTT DMN9MPX RN Radiopharmaceutical therapy in cancer: clinical advances and challenges. Nat Rev Drug Discov. 2020 Sep;19(9):589-608. DMN9MPX RU https://pubmed.ncbi.nlm.nih.gov/32728208 DM2SQBF DI DM2SQBF DM2SQBF DN 225Ac-labelled aCD33 DM2SQBF MI TTJVYO3 DM2SQBF MN Myeloid cell surface antigen CD33 (CD33) DM2SQBF MT DTT DM2SQBF RN Radiopharmaceutical therapy in cancer: clinical advances and challenges. Nat Rev Drug Discov. 2020 Sep;19(9):589-608. DM2SQBF RU https://pubmed.ncbi.nlm.nih.gov/32728208 DM3E2IY DI DM3E2IY DM3E2IY DN 225Ac-labelled aCD38 DM3E2IY MI TTPURFN DM3E2IY MN Cyclic ADP-ribose hydrolase 1 (CD38) DM3E2IY MT DTT DM3E2IY RN Radiopharmaceutical therapy in cancer: clinical advances and challenges. Nat Rev Drug Discov. 2020 Sep;19(9):589-608. DM3E2IY RU https://pubmed.ncbi.nlm.nih.gov/32728208 DM1ZY6M DI DM1ZY6M DM1ZY6M DN 227Th-labelled MSLN-TTC DM1ZY6M MI TT4RXME DM1ZY6M MN Mesothelin (MSLN) DM1ZY6M MT DTT DM1ZY6M RN Mesothelin-Targeted Thorium-227 Conjugate (MSLN-TTC): Preclinical Evaluation of a New Targeted Alpha Therapy for Mesothelin-Positive Cancers. Clin Cancer Res. 2019 Aug 1;25(15):4723-4734. DM1ZY6M RU https://pubmed.ncbi.nlm.nih.gov/31064781 DM7L45S DI DM7L45S DM7L45S DN 227Th-labelled PSMA-TTC DM7L45S MI TT9G4N0 DM7L45S MN Glutamate carboxypeptidase II (GCPII) DM7L45S MT DTT DM7L45S RN Darolutamide Potentiates the Antitumor Efficacy of a PSMA-targeted Thorium-227 Conjugate by a Dual Mode of Action in Prostate Cancer Models. Clin Cancer Res. 2021 May 25. DM7L45S RU https://pubmed.ncbi.nlm.nih.gov/34035067 DMDFA3E DI DMDFA3E DMDFA3E DN 349U85.HCL DMDFA3E MI TTZCG4L DMDFA3E MN Phosphodiesterase 3 (PDE3) DMDFA3E MT DTT DMDFA3E MA Modulator DMDFA3E RN Pharmacokinetics and pharmacodynamics of a new cardiotonic vasodilator agent, 349U85, in normal subjects. Clin Pharmacol Ther. 1994 Jan;55(1):55-63. DMDFA3E RU https://pubmed.ncbi.nlm.nih.gov/8299318 DM4Z1CH DI DM4Z1CH DM4Z1CH DN 4-aminosalicylate sodium DM4Z1CH MI TTK0943 DM4Z1CH MN Prostaglandin G/H synthase (COX) DM4Z1CH MT DTT DM4Z1CH MA Modulator DM4Z1CH RN 5-aminosalicylic acid mediates expression of cyclooxygenase-2 and 15-hydroxyprostaglandin dehydrogenase to suppress colorectal tumorigenesis. Anticancer Res. 2012 Apr;32(4):1193-202. DM4Z1CH RU https://pubmed.ncbi.nlm.nih.gov/22493349 DM8XMPT DI DM8XMPT DM8XMPT DN 4SC-203 DM8XMPT MI TTGJCWZ DM8XMPT MN Fms-like tyrosine kinase 3 (FLT-3) DM8XMPT MT DTT DM8XMPT MA Modulator DM8XMPT RN Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41. DM8XMPT RU https://www.ncbi.nlm.nih.gov/pubmed/15950434 DMG75P3 DI DMG75P3 DMG75P3 DN 4SC-205 DMG75P3 MI TTTRP0H DMG75P3 MN Kinesin-like protein KIF11 (KIF11) DMG75P3 MT DTT DMG75P3 MA Inhibitor DMG75P3 RN 2011 Pipeline of 4SC AG. DMG75P3 RU http://www.pharmaceutical-market-research.com/publications/pharmaceutical_companies/4sc_ag_product_pipeline_review.html DM5RLM4 DI DM5RLM4 DM5RLM4 DN 4SCAR19 cells DM5RLM4 MI TTW640A DM5RLM4 MN B-lymphocyte surface antigen B4 (CD19) DM5RLM4 MT DTT DM5RLM4 MA CAR-T-Cell-Therapy DM5RLM4 RN ClinicalTrials.gov (NCT02968472) A Phase I Trial of 4SCAR19 Cells in the Treatment of Relapsed and Refractory B Cell Leukemia DM5RLM4 RU https://clinicaltrials.gov/ct2/show/NCT02968472 DM0351T DI DM0351T DM0351T DN 5-FP DM0351T MI TTUTN1I DM0351T MN Human Deoxyribonucleic acid (hDNA) DM0351T MT DTT DM0351T MA Binder DM0351T RN Is the measurement of thymidylate synthase to determine suitability for treatment with 5-fluoropyrimidines ready for prime time. Clin Cancer Res. 2003 Apr;9(4):1235-9. DM0351T RU https://pubmed.ncbi.nlm.nih.gov/12684389 DMOIE05 DI DMOIE05 DMOIE05 DN 609A DMOIE05 MI TTNBFWK DMOIE05 MN Programmed cell death protein 1 (PD-1) DMOIE05 MT DTT DMOIE05 MA Inhibitor DMOIE05 RN Clinical pipeline report, company report or official report of 3SBio. DMOIE05 RU http://www.3sbio.com/en/news/details.aspx?id=111 DMQ789Z DI DMQ789Z DMQ789Z DN 8H9 DMQ789Z MI TTUCPMY DMQ789Z MN Tenascin (TNC) DMQ789Z MT DTT DMQ789Z RN In vitro and in vivo cytotoxic activities of recombinant immunotoxin 8H9(Fv)-PE38 against breast cancer, osteosarcoma, and neuroblastoma. Cancer Res. 2004 Feb 15;64(4):1419-24. DMQ789Z RU https://pubmed.ncbi.nlm.nih.gov/14973056 DMJR6TC DI DMJR6TC DMJR6TC DN 90Y-cG250 DMJR6TC MI TT2LVK8 DMJR6TC MN Carbonic anhydrase IX (CA-IX) DMJR6TC MT DTT DMJR6TC RN Application of monoclonal antibody G250 recognizing carbonic anhydrase IX in renal cell carcinoma. Int J Mol Sci. 2013 May 29;14(6):11402-23. DMJR6TC RU https://pubmed.ncbi.nlm.nih.gov/23759990 DMJB6E2 DI DMJB6E2 DMJB6E2 DN 99mTc-MIP-1405 DMJB6E2 MI TT9G4N0 DMJB6E2 MN Glutamate carboxypeptidase II (GCPII) DMJB6E2 MT DTT DMJB6E2 MA Modulator DMJB6E2 RN 99mTc-labeled small-molecule inhibitors of prostate-specific membrane antigen for molecular imaging of prostate cancer. J Nucl Med. 2013 Aug;54(8):1369-76. DMJB6E2 RU https://pubmed.ncbi.nlm.nih.gov/23733925 DMYKPXJ DI DMYKPXJ DMYKPXJ DN 9cUAB-30 DMYKPXJ MI TTH029C DMYKPXJ MN Retinoic acid receptor RXR-gamma (RXRG) DMYKPXJ MT DTT DMYKPXJ MA Modulator DMYKPXJ RN In vitro metabolic characterization, phenotyping, and kinetic studies of 9cUAB30, a retinoid X receptor-specific retinoid. Drug Metab Dispos. 2007 Jul;35(7):1157-64. DMYKPXJ RU https://pubmed.ncbi.nlm.nih.gov/17446266 DMGJ7A4 DI DMGJ7A4 DMGJ7A4 DN A/Anhui/05 DMGJ7A4 MI TTF4CAM DMGJ7A4 MN Influenza Hemagglutinin (Influ HA) DMGJ7A4 MT DTT DMGJ7A4 RN A Human Antibody Recognizing a Conserved Epitope of H5 Hemagglutinin Broadly Neutralizes Highly Pathogenic Avian Influenza H5N1 Viruses. J Virol. 2012 March; 86(6): 2978-2989. DMGJ7A4 RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3302345/ DMRWTFG DI DMRWTFG DMRWTFG DN A-337 DMRWTFG MI TTUN7MC DMRWTFG MN T-cell surface glycoprotein CD3 (CD3) DMRWTFG MT DTT DMRWTFG MA Inhibitor DMRWTFG RN Bispecific antibodies: a mechanistic review of the pipeline. Nat Rev Drug Discov. 2019 Aug;18(8):585-608. DMRWTFG RU https://pubmed.ncbi.nlm.nih.gov/31175342 DMRWTFG DI DMRWTFG DMRWTFG DN A-337 DMRWTFG MI TTZ8WH4 DMRWTFG MN Tumor-associated calcium signal transducer 1 (EPCAM) DMRWTFG MT DTT DMRWTFG MA Inhibitor DMRWTFG RN Bispecific antibodies: a mechanistic review of the pipeline. Nat Rev Drug Discov. 2019 Aug;18(8):585-608. DMRWTFG RU https://pubmed.ncbi.nlm.nih.gov/31175342 DM25CBW DI DM25CBW DM25CBW DN A-348441 DM25CBW MI TTOZRK6 DM25CBW MN Glucocorticoid receptor messenger RNA (GCR mRNA) DM25CBW MT DTT DM25CBW MA Inhibitor DM25CBW RN Synthesis and activity of novel bile-acid conjugated glucocorticoid receptor antagonists. Bioorg Med Chem Lett. 2006 Dec 1;16(23):6086-90. DM25CBW RU https://pubmed.ncbi.nlm.nih.gov/16987661 DMX0JLI DI DMX0JLI DMX0JLI DN A-837093 DMX0JLI MI TTMVBWH DMX0JLI MN Hepatitis C virus RNA-directed RNA polymerase (HCV NS5B) DMX0JLI MT DTT DMX0JLI MA Inhibitor DMX0JLI RN Emerging drugs for hepatitis C. Expert Opin Emerg Drugs. 2008 Mar;13(1):1-19. DMX0JLI RU https://pubmed.ncbi.nlm.nih.gov/18321145 DM92RQT DI DM92RQT DM92RQT DN AAB-003/PF-05236812 DM92RQT MI TTE4KHA DM92RQT MN Amyloid beta A4 protein (APP) DM92RQT MT DTT DM92RQT MA Modulator DM92RQT RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2402). DM92RQT RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2402 DMG4RK0 DI DMG4RK0 DMG4RK0 DN AAD-2004 DMG4RK0 MI TTYLQ8V DMG4RK0 MN Prostaglandin E synthase (PTGES) DMG4RK0 MT DTT DMG4RK0 MA Inhibitor DMG4RK0 RN Concurrent blockade of free radical and microsomal prostaglandin E synthase-1-mediated PGE2 production improves safety and efficacy in a mouse model of amyotrophic lateral sclerosis. J Neurochem. 2012 Sep;122(5):952-61. DMG4RK0 RU https://pubmed.ncbi.nlm.nih.gov/22537108 DMIX5HF DI DMIX5HF DMIX5HF DN AAV2/8-LSPhGAA DMIX5HF MI TTHCF4J DMIX5HF MN Alpha-glucosidase (GLA) DMIX5HF MT DTT DMIX5HF RN ClinicalTrials.gov (NCT03533673) AAV2/8-LSPhGAA in Late-Onset Pompe Disease. U.S. National Institutes of Health. DMIX5HF RU https://clinicaltrials.gov/ct2/show/NCT03533673 DMIDEKB DI DMIDEKB DMIDEKB DN AAV2-hFIX16 DMIDEKB MI TTFEZ5Q DMIDEKB MN Coagulation factor IX (F9) DMIDEKB MT DTT DMIDEKB MA Modulator DMIDEKB RN Assessing the potential for AAV vector genotoxicity in a murine model. Correction in: Blood. 2011 June 16; 117(24): 6739. DMIDEKB RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3069673/ DMBG9HI DI DMBG9HI DMBG9HI DN AB023 DMBG9HI MI TTJCPUT DMBG9HI MN Coagulation factor XI (F11) DMBG9HI MT DTT DMBG9HI MA Inhibitor DMBG9HI RN Contact Activation Inhibitor and Factor XI Antibody, AB023, Produces Safe, Dose-Dependent Anticoagulation in a Phase 1 First-In-Human Trial. Arterioscler Thromb Vasc Biol. 2019 Apr;39(4):799-809. DMBG9HI RU https://pubmed.ncbi.nlm.nih.gov/30700130 DMGONUE DI DMGONUE DMGONUE DN AB680 DMGONUE MI TTK0O6Y DMGONUE MN Ecto-5'-nucleotidase (CD73) DMGONUE MT DTT DMGONUE MA Inhibitor DMGONUE RN Discovery of AB680: A Potent and Selective Inhibitor of CD73. J Med Chem. 2020 Oct 22;63(20):11448-11468. DMGONUE RU https://pubmed.ncbi.nlm.nih.gov/32614585 DMYFB10 DI DMYFB10 DMYFB10 DN Abaperidone DMYFB10 MI TTJQOD7 DMYFB10 MN 5-HT 2A receptor (HTR2A) DMYFB10 MT DTT DMYFB10 MA Modulator DMYFB10 RN 7-[3-(1-piperidinyl)propoxy]chromenones as potential atypical antipsychotics. 2. Pharmacological profile of 7-[3-[4-(6-fluoro-1, 2-benzisoxazol-3-yl)-piperidin-1-yl]propoxy]-3-(hydroxymeth yl)chromen -4-one (abaperidone, FI-8602). J Med Chem. 1998 Dec 31;41(27):5402-9. DMYFB10 RU https://www.ncbi.nlm.nih.gov/pubmed/9876110 DMYFB10 DI DMYFB10 DMYFB10 DN Abaperidone DMYFB10 MI TTEX248 DMYFB10 MN Dopamine D2 receptor (D2R) DMYFB10 MT DTT DMYFB10 MA Modulator DMYFB10 RN 7-[3-(1-piperidinyl)propoxy]chromenones as potential atypical antipsychotics. 2. Pharmacological profile of 7-[3-[4-(6-fluoro-1, 2-benzisoxazol-3-yl)-piperidin-1-yl]propoxy]-3-(hydroxymeth yl)chromen -4-one (abaperidone, FI-8602). J Med Chem. 1998 Dec 31;41(27):5402-9. DMYFB10 RU https://www.ncbi.nlm.nih.gov/pubmed/9876110 DMIQXDJ DI DMIQXDJ DMIQXDJ DN ABBV-151 DMIQXDJ MI TTR9XHZ DMIQXDJ MN Transforming growth factor beta 1 (TGFB1) DMIQXDJ MT DTT DMIQXDJ MA Inhibitor DMIQXDJ RN Clinical pipeline report, company report or official report of AbbVie. DMIQXDJ RU https://www.abbvie.com/our-science/pipeline/abbv-151.html DM71Q69 DI DM71Q69 DM71Q69 DN ABBV-184 DM71Q69 MI TTUN7MC DM71Q69 MN T-cell surface glycoprotein CD3 (CD3) DM71Q69 MT DTT DM71Q69 RN Clinical pipeline report, company report or official report of AbbVie. DM71Q69 RU https://www.abbvie.com/our-science/pipeline/abbv-184.html DMUCF9L DI DMUCF9L DMUCF9L DN ABBV-2451 DMUCF9L MI TTRLZHP DMUCF9L MN cAMP-dependent chloride channel (CFTR) DMUCF9L MT DTT DMUCF9L MA Modulator DMUCF9L RN Antibodies and venom peptides: new modalities for ion channels. Nat Rev Drug Discov. 2019 May;18(5):339-357. DMUCF9L RU https://pubmed.ncbi.nlm.nih.gov/30728472 DMCZI8L DI DMCZI8L DMCZI8L DN ABBV-257 DMCZI8L MI TTG0MT6 DMCZI8L MN Interleukin-17 (IL17) DMCZI8L MT DTT DMCZI8L MA Inhibitor DMCZI8L RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMCZI8L RU http://phrma-docs.phrma.org/files/dmfile/medicines-in-development-drug-list-autoimmune-diseases.pdf DMCZI8L DI DMCZI8L DMCZI8L DN ABBV-257 DMCZI8L MI TTF8CQI DMCZI8L MN Tumor necrosis factor (TNF) DMCZI8L MT DTT DMCZI8L MA Inhibitor DMCZI8L RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMCZI8L RU http://phrma-docs.phrma.org/files/dmfile/medicines-in-development-drug-list-autoimmune-diseases.pdf DMU6K37 DI DMU6K37 DMU6K37 DN ABBV-2737 DMU6K37 MI TTRLZHP DMU6K37 MN cAMP-dependent chloride channel (CFTR) DMU6K37 MT DTT DMU6K37 MA Modulator DMU6K37 RN Antibodies and venom peptides: new modalities for ion channels. Nat Rev Drug Discov. 2019 May;18(5):339-357. DMU6K37 RU https://pubmed.ncbi.nlm.nih.gov/30728472 DMB01L5 DI DMB01L5 DMB01L5 DN ABBV-3067 DMB01L5 MI TTRLZHP DMB01L5 MN cAMP-dependent chloride channel (CFTR) DMB01L5 MT DTT DMB01L5 MA Modulator DMB01L5 RN Antibodies and venom peptides: new modalities for ion channels. Nat Rev Drug Discov. 2019 May;18(5):339-357. DMB01L5 RU https://pubmed.ncbi.nlm.nih.gov/30728472 DM49O6Y DI DM49O6Y DM49O6Y DN ABBV-323 DM49O6Y MI TTN6Y9A DM49O6Y MN CD40L receptor (CD40) DM49O6Y MT DTT DM49O6Y MA Antagonist DM49O6Y RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DM49O6Y RU http://phrma-docs.phrma.org/files/dmfile/medicines-in-development-drug-list-autoimmune-diseases.pdf DMQGPRE DI DMQGPRE DMQGPRE DN ABBV-399 DMQGPRE MI TTNDSF4 DMQGPRE MN Proto-oncogene c-Met (MET) DMQGPRE MT DTT DMQGPRE MA Inhibitor DMQGPRE RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMQGPRE RU http://phrma-docs.phrma.org/files/dmfile/MID_Immuno-Oncology-2017_Drug-List1.pdf DMPD0KL DI DMPD0KL DMPD0KL DN ABBV-428 DMPD0KL MI TTIJP3Q DMPD0KL MN TNF related activation protein (CD40LG) DMPD0KL MT DTT DMPD0KL MA Stimulator DMPD0KL RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMPD0KL RU http://phrma-docs.phrma.org/files/dmfile/MID_Immuno-Oncology-2017_Drug-List1.pdf DM87SM9 DI DM87SM9 DM87SM9 DN ABBV-467 DM87SM9 MI TTL53M6 DM87SM9 MN Induced myeloid leukemia cell differentiation protein Mcl-1 (MCL1) DM87SM9 MT DTT DM87SM9 MA Inhibitor DM87SM9 RN Clinical pipeline report, company report or official report of AbbVie. DM87SM9 RU https://www.abbvie.com/our-science/pipeline/abbv-467.html DM90EO3 DI DM90EO3 DM90EO3 DN ABBV-621 DM90EO3 MI TTA5MS9 DM90EO3 MN TNF related apoptosis inducing ligand (TNFSF10) DM90EO3 MT DTT DM90EO3 MA Agonist DM90EO3 RN Clinical pipeline report, company report or official report of AbbVie. DM90EO3 RU https://www.abbvie.com/our-science/pipeline/abbv-621.html DMTEA9C DI DMTEA9C DMTEA9C DN ABBV-744 DMTEA9C MI TTDP48B DMTEA9C MN Bromodomain-containing protein 2 (BRD2) DMTEA9C MT DTT DMTEA9C MA Inhibitor DMTEA9C RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMTEA9C RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DMTEA9C DI DMTEA9C DMTEA9C DN ABBV-744 DMTEA9C MI TTHE657 DMTEA9C MN Bromodomain-containing protein 3 (BRD3) DMTEA9C MT DTT DMTEA9C MA Inhibitor DMTEA9C RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMTEA9C RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DMTEA9C DI DMTEA9C DMTEA9C DN ABBV-744 DMTEA9C MI TTRA6BO DMTEA9C MN Bromodomain-containing protein 4 (BRD4) DMTEA9C MT DTT DMTEA9C MA Inhibitor DMTEA9C RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMTEA9C RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DMZM0T8 DI DMZM0T8 DMZM0T8 DN ABBV-838 DMZM0T8 MI TT7ILZ1 DMZM0T8 MN SLAM family member 7 SLAMF7 (CS1) DMZM0T8 MT DTT DMZM0T8 MA Inhibitor DMZM0T8 RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMZM0T8 RU http://phrma-docs.phrma.org/files/dmfile/MID_Immuno-Oncology-2017_Drug-List1.pdf DMPXDL6 DI DMPXDL6 DMPXDL6 DN ABBV-CLS-579 DMPXDL6 MI TTY8PUS DMPXDL6 MN Tyrosine-protein phosphatase non-receptor type 2 (PTPN2) DMPXDL6 MT DTT DMPXDL6 MA Inhibitor DMPXDL6 RN Clinical pipeline report, company report or official report of Calico Life Sciences. DMPXDL6 RU https://www.calicolabs.com/press/calico-and-abbvie-share-update-on-early-stage-clinical-programs DMUSOM9 DI DMUSOM9 DMUSOM9 DN ABBV-CX-2029 DMUSOM9 MI TT8MG4S DMUSOM9 MN Transferrin receptor protein 1 (TFRC) DMUSOM9 MT DTT DMUSOM9 RN Clinical pipeline report, company report or official report of AbbVie. DMUSOM9 RU https://www.abbvie.com/our-science/pipeline/abbv-2029.html DM1KD7U DI DM1KD7U DM1KD7U DN ABI-011 DM1KD7U MI TTB8Y9K DM1KD7U MN Angiogenesis (AGG) DM1KD7U MT DTT DM1KD7U MA Inhibitor DM1KD7U RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DM1KD7U RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DM1KD7U DI DM1KD7U DM1KD7U DN ABI-011 DM1KD7U MI TTGTQHC DM1KD7U MN DNA topoisomerase I (TOP1) DM1KD7U MT DTT DM1KD7U MA Modulator DM1KD7U RN Company report (Indena) DM1KD7U RU http://cn.indena.com/news/indena-nerviano-medical-sciences-agree-scale-new-high-potency-molecules-4/ DM1KD7U DI DM1KD7U DM1KD7U DN ABI-011 DM1KD7U MI TT4V2JM DM1KD7U MN Hepatocyte growth factor (HGF) DM1KD7U MT DTT DM1KD7U MA Inhibitor DM1KD7U RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DM1KD7U RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DM1KD7U DI DM1KD7U DM1KD7U DN ABI-011 DM1KD7U MI TTYFKSZ DM1KD7U MN Tubulin beta (TUBB) DM1KD7U MT DTT DM1KD7U MA Modulator DM1KD7U RN Company report (Indena) DM1KD7U RU http://cn.indena.com/news/indena-nerviano-medical-sciences-agree-scale-new-high-potency-molecules-4/ DM1KD7U DI DM1KD7U DM1KD7U DN ABI-011 DM1KD7U MI TTOHSBA DM1KD7U MN Vascular endothelial growth factor A (VEGFA) DM1KD7U MT DTT DM1KD7U MA Inhibitor DM1KD7U RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DM1KD7U RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DM4TN6W DI DM4TN6W DM4TN6W DN ABI-H3733 DM4TN6W MI TTM42UJ DM4TN6W MN Hepatitis B virus Capsid protein (HBV C) DM4TN6W MT DTT DM4TN6W MA Inhibitor DM4TN6W RN Clinical pipeline report, company report or official report of Assembly Biosciences. DM4TN6W RU https://www.assemblybio.com/pipeline/ DMS1HR3 DI DMS1HR3 DMS1HR3 DN ABM-1310 DMS1HR3 MI TTWCGQT DMS1HR3 MN Serine/threonine-protein kinase B-raf (BRAF) DMS1HR3 MT DTT DMS1HR3 MA Inhibitor DMS1HR3 RN Clinical pipeline report, company report or official report of ABM Therapeutics. DMS1HR3 RU http://www.abmtx.com/site/development3 DMA4WEO DI DMA4WEO DMA4WEO DN ABSK021 DMA4WEO MI TT7MRDV DMA4WEO MN Macrophage colony-stimulating factor 1 receptor (CSF1R) DMA4WEO MT DTT DMA4WEO MA Inhibitor DMA4WEO RN Clinical pipeline report, company report or official report of Abbisko Therapeutics. DMA4WEO RU http://www.abbisko.com/page104?_l=en DMG4H9Y DI DMG4H9Y DMG4H9Y DN ABT-072 DMG4H9Y MI TTMVBWH DMG4H9Y MN Hepatitis C virus RNA-directed RNA polymerase (HCV NS5B) DMG4H9Y MT DTT DMG4H9Y MA Inhibitor DMG4H9Y RN Clinical pipeline report, company report or official report of Abbott Laboratories (2011) DMG4H9Y RU http://www.abbott.com/index2.htm DMJFWPR DI DMJFWPR DMJFWPR DN ABT-102 DMJFWPR MI TTMI6F5 DMJFWPR MN Transient receptor potential cation channel V1 (TRPV1) DMJFWPR MT DTT DMJFWPR MA Blocker DMJFWPR RN Analgesic potential of TRPV1 antagonists. Biochem Pharmacol. 2009 Aug 1;78(3):211-6. DMJFWPR RU https://pubmed.ncbi.nlm.nih.gov/19481638 DM1F50I DI DM1F50I DM1F50I DN ABT-110 DM1F50I MI TTDN3LF DM1F50I MN Nerve growth factor (NGF) DM1F50I MT DTT DM1F50I MA Modulator DM1F50I RN Fate of novel painkiller mAbs hangs in balance.Nat Biotechnol.2011 Mar;29(3):173-4. DM1F50I RU https://www.ncbi.nlm.nih.gov/pubmed/21389990 DMQ3O1U DI DMQ3O1U DMQ3O1U DN ABT-165 DMQ3O1U MI TTV23LH DMQ3O1U MN Delta-like protein 4 (DLL4) DMQ3O1U MT DTT DMQ3O1U MA Inhibitor DMQ3O1U RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMQ3O1U RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DMQ3O1U DI DMQ3O1U DMQ3O1U DN ABT-165 DMQ3O1U MI TT9HKJA DMQ3O1U MN Vascular endothelial growth factor (VEGF) DMQ3O1U MT DTT DMQ3O1U MA Inhibitor DMQ3O1U RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMQ3O1U RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DMR7OGL DI DMR7OGL DMR7OGL DN ABT-239 DMR7OGL MI TT9JNIC DMR7OGL MN Histamine H3 receptor (H3R) DMR7OGL MT DTT DMR7OGL MA Antagonist DMR7OGL RN Use of the H3 receptor antagonist radioligand [3H]-A-349821 to reveal in vivo receptor occupancy of cognition enhancing H3 receptor antagonists. Br J Pharmacol. 2009 May;157(1):139-49. DMR7OGL RU https://pubmed.ncbi.nlm.nih.gov/19413577 DM7TOWX DI DM7TOWX DM7TOWX DN ABT-333 DM7TOWX MI DES5XRU DM7TOWX MN Cytochrome P450 2C8 (CYP2C8) DM7TOWX MT DME DM7TOWX MA Metabolism DM7TOWX RN Metabolism and disposition of hepatitis C polymerase inhibitor dasabuvir in humans. Drug Metab Dispos. 2016 Aug;44(8):1139-47. DM7TOWX RU https://www.ncbi.nlm.nih.gov/pubmed/?term=27179126 DM7TOWX DI DM7TOWX DM7TOWX DN ABT-333 DM7TOWX MI DECB0K3 DM7TOWX MN Cytochrome P450 2D6 (CYP2D6) DM7TOWX MT DME DM7TOWX MA Metabolism DM7TOWX RN Metabolism and disposition of hepatitis C polymerase inhibitor dasabuvir in humans. Drug Metab Dispos. 2016 Aug;44(8):1139-47. DM7TOWX RU https://www.ncbi.nlm.nih.gov/pubmed/?term=27179126 DM7TOWX DI DM7TOWX DM7TOWX DN ABT-333 DM7TOWX MI DE4LYSA DM7TOWX MN Cytochrome P450 3A4 (CYP3A4) DM7TOWX MT DME DM7TOWX MA Metabolism DM7TOWX RN Metabolism and disposition of hepatitis C polymerase inhibitor dasabuvir in humans. Drug Metab Dispos. 2016 Aug;44(8):1139-47. DM7TOWX RU https://www.ncbi.nlm.nih.gov/pubmed/?term=27179126 DM7TOWX DI DM7TOWX DM7TOWX DN ABT-333 DM7TOWX MI TTMVBWH DM7TOWX MN Hepatitis C virus RNA-directed RNA polymerase (HCV NS5B) DM7TOWX MT DTT DM7TOWX MA Inhibitor DM7TOWX RN Clinical pipeline report, company report or official report of Abbott Laboratories (2011) DM7TOWX RU http://www.abbott.com/index2.htm DM7TOWX DI DM7TOWX DM7TOWX DN ABT-333 DM7TOWX MI DTUGYRD DM7TOWX MN P-glycoprotein 1 (ABCB1) DM7TOWX MT DTP DM7TOWX MA Substrate DM7TOWX RN Tarascon Pocket Pharmacopoeia 2018 Classic Shirt-Pocket Edition. DM7TOWX RU https://books.google.com/books?id=0gBRDwAAQBAJ&pg=PP37&lpg=PP37&dq=Methylergonovine+transporter+uptake+efflex&source=bl&ots=cUTe_ppsmZ&sig=ACfU3U3E_YqrDg0CNEuj8K-7lci47HAnrg&hl=zh-CN&sa=X&ved=2ahUKEwjnj-Dk7d7iAhUsK6YKHd5DBDkQ6AEwEnoECAgQAQ#v=onepage&q&f=false DMWN7D3 DI DMWN7D3 DMWN7D3 DN ABT-354 DMWN7D3 MI TTJS8PY DMWN7D3 MN 5-HT 6 receptor (HTR6) DMWN7D3 MT DTT DMWN7D3 MA Modulator DMWN7D3 RN Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800035134) DMWN7D3 RU http://adisinsight.springer.com/drugs/800035134 DM4KPV0 DI DM4KPV0 DM4KPV0 DN ABT-413 DM4KPV0 MI TTS9BDA DM4KPV0 MN Spectrin non-erythroid beta chain 1 (SPTBN1) DM4KPV0 MT DTT DM4KPV0 RN The Discovery of Novel Selective D1 Dopaminergic Agonists: A-68930, A-77636, A-86929, and ABT-413. International Journal of Medicinal Chemistry Volume 2011 (2011), Article ID 424535, Page(8). DM4KPV0 RU http://www.hindawi.com/journals/ijmc/2011/424535/ DMVLPRT DI DMVLPRT DMVLPRT DN ABT-700 DMVLPRT MI TTNDSF4 DMVLPRT MN Proto-oncogene c-Met (MET) DMVLPRT MT DTT DMVLPRT MA Modulator DMVLPRT RN J Clin Oncol 32:5s, 2014 (suppl; abstr 2507). DMVLPRT RU http://meetinglibrary.asco.org/content/134301-144 DMFH3JM DI DMFH3JM DMFH3JM DN ABT-767 DMFH3JM MI TTEBCY8 DMFH3JM MN Poly [ADP-ribose] polymerase (PARP) DMFH3JM MT DTT DMFH3JM MA Modulator DMFH3JM RN Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41. DMFH3JM RU https://www.ncbi.nlm.nih.gov/pubmed/15950434 DMB9N4J DI DMB9N4J DMB9N4J DN ABT-957 DMB9N4J MI TTG5QB7 DMB9N4J MN Calpain-2 (CAPN2) DMB9N4J MT DTT DMB9N4J MA Modulator DMB9N4J RN Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41. DMB9N4J RU https://www.ncbi.nlm.nih.gov/pubmed/15950434 DM9SYVJ DI DM9SYVJ DM9SYVJ DN ABX-1431 DM9SYVJ MI TTZ963I DM9SYVJ MN Monoglyceride lipase (MAGL) DM9SYVJ MT DTT DM9SYVJ MA Inhibitor DM9SYVJ RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DM9SYVJ RU http://phrma-docs.phrma.org/files/dmfile/MID_Neurological-Disorders-Drug-List_2018.pdf DMS3915 DI DMS3915 DMS3915 DN AC 165198 DMS3915 MI TTUPB12 DMS3915 MN Measles virus Fusion glycoprotein (MeV F) DMS3915 MT DTT DMS3915 MA Modulator DMS3915 RN WO patent application no. 2013,1306,83, Xten conjugate compositions and methods of making same. DMS3915 RU http://worldwide.espacenet.com/publicationDetails/biblio?DB=worldwide.espacenet.com&II=0&ND=3&adjacent=true&locale=en_EP&FT=D&date=20130906&CC=WO&NR=2013130683A2&KC=A2 DMB5A63 DI DMB5A63 DMB5A63 DN AC0058TA DMB5A63 MI TTGM6VW DMB5A63 MN Tyrosine-protein kinase BTK (ATK) DMB5A63 MT DTT DMB5A63 MA Inhibitor DMB5A63 RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMB5A63 RU http://phrma-docs.phrma.org/files/dmfile/medicines-in-development-drug-list-autoimmune-diseases.pdf DM36WTQ DI DM36WTQ DM36WTQ DN AC-262271 DM36WTQ MI TTZ9SOR DM36WTQ MN Muscarinic acetylcholine receptor M1 (CHRM1) DM36WTQ MT DTT DM36WTQ MA Agonist DM36WTQ RN Phase I clinical trial of muscarinic agonist (AC-262271) for treating glaucoma. Acadia Pharmaceuticals. DM36WTQ RU http://www.biocentury.com/products/ac-262271 DMPS6U9 DI DMPS6U9 DMPS6U9 DN AC430 DMPS6U9 MI TTRMX3V DMPS6U9 MN Janus kinase 2 (JAK-2) DMPS6U9 MT DTT DMPS6U9 MA Modulator DMPS6U9 RN Selective JAK inhibitors in development for rheumatoid arthritis. Expert Opin Investig Drugs. 2014 Aug;23(8):1067-77. DMPS6U9 RU https://pubmed.ncbi.nlm.nih.gov/24818516 DMJ36YH DI DMJ36YH DMJ36YH DN ACE-011 DMJ36YH MI TTO3HT7 DMJ36YH MN Transforming growth factor beta (TGFB) DMJ36YH MT DTT DMJ36YH MA Inhibitor DMJ36YH RN Clinical pipeline report, company report or official report of Acceleron Pharma (2011). DMJ36YH RU http://www.acceleronpharma.com/ DMUBYFM DI DMUBYFM DMUBYFM DN ACE-041 DMUBYFM MI TTAP4T1 DMUBYFM MN Growth/differentiation factor 2 (GDF2) DMUBYFM MT DTT DMUBYFM MA Modulator DMUBYFM RN Company report (Acceleron Pharma) DMUBYFM RU http://www.acceleronpharma.com/products/dalantercept/ DM19UTO DI DM19UTO DM19UTO DN Acebilustat DM19UTO MI TTXZEAJ DM19UTO MN Leukotriene A-4 hydrolase (LTA4H) DM19UTO MT DTT DM19UTO MA Inhibitor DM19UTO RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DM19UTO RU http://phrma-docs.phrma.org/files/dmfile/MID_Skin_Diseases_2018_9_FINAL.pdf DMW6X0O DI DMW6X0O DMW6X0O DN ACH-2684 DMW6X0O MI TTWXB3E DMW6X0O MN Hepatitis C virus NS3 helicase (HCV NS3) DMW6X0O MT DTT DMW6X0O MA Modulator DMW6X0O RN Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41. DMW6X0O RU https://www.ncbi.nlm.nih.gov/pubmed/15950434 DM5SJO9 DI DM5SJO9 DM5SJO9 DN ACHN-975 DM5SJO9 MI TT2D1J6 DM5SJO9 MN Haemophilus influenzae Acetylglucosamine deacetylase (Hae-influ lpxC) DM5SJO9 MT DTT DM5SJO9 MA Modulator DM5SJO9 RN Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41. DM5SJO9 RU https://www.ncbi.nlm.nih.gov/pubmed/15950434 DMKVE8X DI DMKVE8X DMKVE8X DN Acriflavine DMKVE8X MI TT5FH9Y DMKVE8X MN Human immunodeficiency virus Integrase (HIV IN) DMKVE8X MT DTT DMKVE8X MA Modulator DMKVE8X RN Why have ten or so nontoxic, retrovirus integrase inhibitors not been made available for AIDS treatment. Biomed Pharmacother. 1999 Dec;53(10):484-6. DMKVE8X RU https://pubmed.ncbi.nlm.nih.gov/10665342 DMOZ3AT DI DMOZ3AT DMOZ3AT DN ACT-178882 DMOZ3AT MI TTB2MXP DMOZ3AT MN Angiotensinogenase renin (REN) DMOZ3AT MT DTT DMOZ3AT MA Inhibitor DMOZ3AT RN Drug-drug interaction study of ACT-178882, a new renin inhibitor, and diltiazem in healthy subjects. Clin Drug Investig. 2013 Mar;33(3):207-13. DMOZ3AT RU https://pubmed.ncbi.nlm.nih.gov/23381958 DM5KMYQ DI DM5KMYQ DM5KMYQ DN Actimab-M DM5KMYQ MI TTJVYO3 DM5KMYQ MN Myeloid cell surface antigen CD33 (CD33) DM5KMYQ MT DTT DM5KMYQ MA Inhibitor DM5KMYQ RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DM5KMYQ RU http://phrma-docs.phrma.org/files/dmfile/MID_Immuno-Oncology-2017_Drug-List1.pdf DMRDY0G DI DMRDY0G DMRDY0G DN ACV-1 DMRDY0G MI TTJ49OM DMRDY0G MN Neuronal acetylcholine receptor alpha-10 (CHRNA10) DMRDY0G MT DTT DMRDY0G MA Modulator DMRDY0G RN Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41. DMRDY0G RU https://www.ncbi.nlm.nih.gov/pubmed/15950434 DM8VQ1S DI DM8VQ1S DM8VQ1S DN AD-337 DM8VQ1S MI TT3ROYC DM8VQ1S MN Serotonin transporter (SERT) DM8VQ1S MT DTT DM8VQ1S MA Modulator DM8VQ1S RN Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41. DM8VQ1S RU https://www.ncbi.nlm.nih.gov/pubmed/15950434 DMG82ZA DI DMG82ZA DMG82ZA DN Ad35-GRIN/ENV DMG82ZA MI TTEC2T3 DMG82ZA MN Human immunodeficiency virus Envelope glycoprotein gp160 (HIV env) DMG82ZA MT DTT DMG82ZA RN A phase I double blind, placebo-controlled, randomized study of a multigenic HIV-1 adenovirus subtype 35 vector vaccine in healthy uninfected adults. PLoS One. 2012;7(8):e41936. DMG82ZA RU https://pubmed.ncbi.nlm.nih.gov/22870265 DMG82ZA DI DMG82ZA DMG82ZA DN Ad35-GRIN/ENV DMG82ZA MI TTFGZB6 DMG82ZA MN Human immunodeficiency virus GAG protein (HIV gag) DMG82ZA MT DTT DMG82ZA RN A phase I double blind, placebo-controlled, randomized study of a multigenic HIV-1 adenovirus subtype 35 vector vaccine in healthy uninfected adults. PLoS One. 2012;7(8):e41936. DMG82ZA RU https://pubmed.ncbi.nlm.nih.gov/22870265 DMG82ZA DI DMG82ZA DMG82ZA DN Ad35-GRIN/ENV DMG82ZA MI TT4NXYM DMG82ZA MN Human immunodeficiency virus Negative factor (HIV nef) DMG82ZA MT DTT DMG82ZA RN A phase I double blind, placebo-controlled, randomized study of a multigenic HIV-1 adenovirus subtype 35 vector vaccine in healthy uninfected adults. PLoS One. 2012;7(8):e41936. DMG82ZA RU https://pubmed.ncbi.nlm.nih.gov/22870265 DMG82ZA DI DMG82ZA DMG82ZA DN Ad35-GRIN/ENV DMG82ZA MI TTF7I5O DMG82ZA MN Human immunodeficiency virus Rev protein (HIV rev) DMG82ZA MT DTT DMG82ZA RN A phase I double blind, placebo-controlled, randomized study of a multigenic HIV-1 adenovirus subtype 35 vector vaccine in healthy uninfected adults. PLoS One. 2012;7(8):e41936. DMG82ZA RU https://pubmed.ncbi.nlm.nih.gov/22870265 DMG82ZA DI DMG82ZA DMG82ZA DN Ad35-GRIN/ENV DMG82ZA MI TT84ETX DMG82ZA MN Human immunodeficiency virus Reverse transcriptase (HIV RT) DMG82ZA MT DTT DMG82ZA RN A phase I double blind, placebo-controlled, randomized study of a multigenic HIV-1 adenovirus subtype 35 vector vaccine in healthy uninfected adults. PLoS One. 2012;7(8):e41936. DMG82ZA RU https://pubmed.ncbi.nlm.nih.gov/22870265 DMFTGHX DI DMFTGHX DMFTGHX DN Ad5CMV-NIS DMFTGHX MI TTW7HI9 DMFTGHX MN Sodium/iodide cotransporter (SLC5A5) DMFTGHX MT DTT DMFTGHX MA Modulator DMFTGHX RN Noninvasive Imaging and Radiovirotherapy of Prostate Cancer Using an Oncolytic Measles Virus Expressing the Sodium Iodide Symporter. Mol Ther. 2009 December; 17(12): 2041-2048. DMFTGHX RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2810133/ DMMBQV3 DI DMMBQV3 DMMBQV3 DN Ad5-ENVA-48 DMMBQV3 MI TTEC2T3 DMMBQV3 MN Human immunodeficiency virus Envelope glycoprotein gp160 (HIV env) DMMBQV3 MT DTT DMMBQV3 RN ClinicalTrials.gov (NCT00695877) Safety and Immune Response to a Recombinant Adenovirus HIV-1 Vaccine in Healthy Adults. U.S. National Institutes of Health. DMMBQV3 RU https://clinicaltrials.gov/ct2/show/NCT00695877 DM2UMGE DI DM2UMGE DM2UMGE DN Ad5-TRAIL DM2UMGE MI TTA5MS9 DM2UMGE MN TNF related apoptosis inducing ligand (TNFSF10) DM2UMGE MT DTT DM2UMGE MA Modulator DM2UMGE RN Enhancement of Ad5-TRAIL cytotoxicity against renal cell carcinoma with histone deacetylase inhibitors. Cancer Gene Ther. 2006 Jun;13(6):628-32. DM2UMGE RU https://pubmed.ncbi.nlm.nih.gov/16456549 DM16QSG DI DM16QSG DM16QSG DN Adaphostin DM16QSG MI TTS7G69 DM16QSG MN Fusion protein Bcr-Abl (Bcr-Abl) DM16QSG MT DTT DM16QSG MA Inhibitor DM16QSG RN Effects of the Bcr/abl kinase inhibitors STI571 and adaphostin (NSC 680410) on chronic myelogenous leukemia cells in vitro. Blood. 2002 Jan 15;99(2):664-71. DM16QSG RU https://pubmed.ncbi.nlm.nih.gov/11781252 DM59EUY DI DM59EUY DM59EUY DN ADCI DM59EUY MI TT9IK2Z DM59EUY MN N-methyl-D-aspartate receptor (NMDAR) DM59EUY MT DTT DM59EUY MA Modulator DM59EUY RN The anticonvulsant SGB-017 (ADCI) blocks voltage-gated sodium channels in rat and human neurons: comparison with carbamazepine. Epilepsia. 2000 Mar;41(3):263-70. DM59EUY RU https://pubmed.ncbi.nlm.nih.gov/10714396 DM59EUY DI DM59EUY DM59EUY DN ADCI DM59EUY MI TTRK8B9 DM59EUY MN Sodium channel unspecific (NaC) DM59EUY MT DTT DM59EUY MA Modulator DM59EUY RN The anticonvulsant SGB-017 (ADCI) blocks voltage-gated sodium channels in rat and human neurons: comparison with carbamazepine. Epilepsia. 2000 Mar;41(3):263-70. DM59EUY RU https://pubmed.ncbi.nlm.nih.gov/10714396 DMEXT97 DI DMEXT97 DMEXT97 DN ADG116 DMEXT97 MI TTI2S1D DMEXT97 MN Cytotoxic T-lymphocyte protein 4 (CTLA-4) DMEXT97 MT DTT DMEXT97 MA Inhibitor DMEXT97 RN Clinical pipeline report, company report or official report of Adagene. DMEXT97 RU https://www.adagene.com/pipeline/adg116/ DMM45P9 DI DMM45P9 DMM45P9 DN Ad-IFN-alpha DMM45P9 MI TT95SOA DMM45P9 MN Interferon alpha (IFNA) DMM45P9 MT DTT DMM45P9 MA Modulator DMM45P9 RN 2007 FDA drug approvals: a year of flux. Nat Rev Drug Discov. 2008 Feb;7(2):107-9. DMM45P9 RU https://pubmed.ncbi.nlm.nih.gov/18246607 DMQVEZB DI DMQVEZB DMQVEZB DN Adjustable basal insulin DMQVEZB MI TTZOPHG DMQVEZB MN Insulin (INS) DMQVEZB MT DTT DMQVEZB MA Modulator DMQVEZB RN The future of basal insulin supplementation. Diabetes Technol Ther. 2011 Jun;13 Suppl 1:S103-8. DMQVEZB RU https://pubmed.ncbi.nlm.nih.gov/21568722 DM9GLHO DI DM9GLHO DM9GLHO DN Ad-OC-hsvTK/valacyclovir DM9GLHO MI TTP3QRF DM9GLHO MN Thymidine kinase 1 (TK1) DM9GLHO MT DTT DM9GLHO MA Inhibitor DM9GLHO RN Phase I dose escalation clinical trial of adenovirus vector carrying osteocalcin promoter-driven herpes simplex virus thymidine kinase in localized and metastatic hormone-refractory prostate cancer. Hum Gene Ther. 2003 Feb 10;14(3):227-41. DM9GLHO RU https://pubmed.ncbi.nlm.nih.gov/12639303 DMS6DPF DI DMS6DPF DMS6DPF DN ADPT01 DMS6DPF MI TTNVXAW DMS6DPF MN Lymphocyte activation gene 3 protein (LAG3) DMS6DPF MT DTT DMS6DPF MA Inhibitor DMS6DPF RN Clinical pipeline report, company report or official report of Novartis. DMS6DPF RU https://www.novartis.com/our-science/novartis-global-pipeline?search_api_views_fulltext=ADPT01&field_pipeline_filing_date=All DMS6DPF DI DMS6DPF DMS6DPF DN ADPT01 DMS6DPF MI TTNBFWK DMS6DPF MN Programmed cell death protein 1 (PD-1) DMS6DPF MT DTT DMS6DPF MA Inhibitor DMS6DPF RN Clinical pipeline report, company report or official report of Novartis. DMS6DPF RU https://www.novartis.com/our-science/novartis-global-pipeline?search_api_views_fulltext=ADPT01&field_pipeline_filing_date=All DM6NUCA DI DM6NUCA DM6NUCA DN ADR-851 DM6NUCA MI TTNXLKE DM6NUCA MN 5-HT 3 receptor (5HT3R) DM6NUCA MT DTT DM6NUCA MA Modulator DM6NUCA RN Analgesic effects of S and R isomers of the novel 5-HT3 receptor antagonists ADR-851 and ADR-882 in rats. Eur J Pharmacol. 1991 Oct 29;204(1):117-9. DM6NUCA RU https://pubmed.ncbi.nlm.nih.gov/1804661 DMYHIAR DI DMYHIAR DMYHIAR DN AdRTVP-1 DMYHIAR MI TTEQF1O DMYHIAR MN Glioma pathogenesis-related protein 1 (GLIPR1) DMYHIAR MT DTT DMYHIAR MA Modulator DMYHIAR RN Adenoviral vector-mediated RTVP-1 gene-modified tumor cell-based vaccine suppresses the development of experimental prostate cancer. Cancer Gene Ther. 2006 Jul;13(7):658-63. DMYHIAR RU https://pubmed.ncbi.nlm.nih.gov/16485011 DMHIPF5 DI DMHIPF5 DMHIPF5 DN ADV-1002401 DMHIPF5 MI TTDLNGZ DMHIPF5 MN Glucokinase (GCK) DMHIPF5 MT DTT DMHIPF5 MA Inhibitor DMHIPF5 RN The Hepatoselective Glucokinase Activator PF-04991532 Ameliorates Hyperglycemia without Causing Hepatic Steatosis in Diabetic Rats. PLoS One. 2014; 9(5): e97139. DMHIPF5 RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4032240/ DMH8Z9W DI DMH8Z9W DMH8Z9W DN ADVAX DMH8Z9W MI TTRPO9Z DMH8Z9W MN TNF-alpha signaling pathway (TNFA pathway) DMH8Z9W MT DTT DMH8Z9W MA Modulator DMH8Z9W RN Phase 1 safety and immunogenicity evaluation of ADVAX, a multigenic, DNA-based clade C/B' HIV-1 candidate vaccine. PLoS One. 2010 Jan 25;5(1):e8617. DMH8Z9W RU https://pubmed.ncbi.nlm.nih.gov/20111582 DMBUOX4 DI DMBUOX4 DMBUOX4 DN ADX71149 DMBUOX4 MI TTXJ47W DMBUOX4 MN Metabotropic glutamate receptor 2 (mGluR2) DMBUOX4 MT DTT DMBUOX4 MA Modulator DMBUOX4 RN MGlu2 receptor-mediated modulation of conditioned avoidance behavior in rats. European journal of pharmacology. 01/2014; 727(1). DMBUOX4 RU http://www.researchgate.net/publication/260023632_MGlu2_receptor-mediated_modulation_of_conditioned_avoidance_behavior_in_rats DM7X2HK DI DM7X2HK DM7X2HK DN AE-08 DM7X2HK MI TT8MK59 DM7X2HK MN Melanocytes lineage-specific antigen GP100 (PMEL) DM7X2HK MT DTT DM7X2HK RN Synthesis of labeled BCX-4208, a potent inhibitor of purine nucleoside phosphorylase. Drug Test Anal. 2009 Mar;1(3):125-7. DM7X2HK RU https://pubmed.ncbi.nlm.nih.gov/20355185 DMQRKXP DI DMQRKXP DMQRKXP DN AEA-35p DMQRKXP MI TTYA75N DMQRKXP MN MHC class II antigen DR (HLA-DR) DMQRKXP MT DTT DMQRKXP RN WO patent application no. 2013,1850,32, Nanotherapeutics for drug targeting. DMQRKXP RU http://worldwide.espacenet.com/publicationDetails/biblio?DB=worldwide.espacenet.com&II=0&ND=3&adjacent=true&locale=en_EP&FT=D&date=20131212&CC=WO&NR=2013185032A1&KC=A1 DM8I4G0 DI DM8I4G0 DM8I4G0 DN AEB701 DM8I4G0 MI TTYVX59 DM8I4G0 MN Protein kinase C (PRKC) DM8I4G0 MT DTT DM8I4G0 MA Inhibitor DM8I4G0 RN Changes in Serum Cytokine Profile after AEB071 (Sotrastaurin) or Tacrolimus versus Their Combinations in Rat Heterotopic Cardiac Allografts. J Korean Soc Transplant. 2012 Dec;26(4):248-253. DM8I4G0 RU http://synapse.koreamed.org/DOIx.php?id=10.4285/jkstn.2012.26.4.248 DMQF982 DI DMQF982 DMQF982 DN AEW-541 DMQF982 MI TTCBFJO DMQF982 MN Insulin receptor (INSR) DMQF982 MT DTT DMQF982 MA Inhibitor DMQF982 RN Inhibition of the insulin-like growth factor-1 receptor (IGF1R) tyrosine kinase as a novel cancer therapy approach. J Med Chem. 2009 Aug 27;52(16):4981-5004. DMQF982 RU https://pubmed.ncbi.nlm.nih.gov/19610618 DMQF982 DI DMQF982 DMQF982 DN AEW-541 DMQF982 MI TTHRID2 DMQF982 MN Insulin-like growth factor I receptor (IGF1R) DMQF982 MT DTT DMQF982 MA Inhibitor DMQF982 RN A comparison of physicochemical property profiles of marketed oral drugs and orally bioavailable anti-cancer protein kinase inhibitors in clinical development. Curr Top Med Chem. 2007;7(14):1408-22. DMQF982 RU https://pubmed.ncbi.nlm.nih.gov/17692029 DM8LG2I DI DM8LG2I DM8LG2I DN AF-130 DM8LG2I MI TT2THBD DM8LG2I MN P2X purinoceptor 3 (P2RX3) DM8LG2I MT DTT DM8LG2I MA Antagonist DM8LG2I RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DM8LG2I RU http://phrma-docs.phrma.org/files/dmfile/2018_Heart-Disease-and-Stroke_MID-Drug-List.pdf DMNF3GW DI DMNF3GW DMNF3GW DN Afeletecan DMNF3GW MI TTGTQHC DMNF3GW MN DNA topoisomerase I (TOP1) DMNF3GW MT DTT DMNF3GW MA Inhibitor DMNF3GW RN The fate of camptothecin glycoconjugate: report of a clinical hold during a phase II study of BAY 56-3722 (formerly BAY 38-3441), in patients with recurrent or metastatic colorectal cancer resistant/refractory to irinotecan. Invest New Drugs. 2012 June; 30(3): 1208-1210. DMNF3GW RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3348469/ DM0I8RZ DI DM0I8RZ DM0I8RZ DN Affitope AD-01 DM0I8RZ MI TTE4KHA DM0I8RZ MN Amyloid beta A4 protein (APP) DM0I8RZ MT DTT DM0I8RZ RN Alzheimer's Disease and the Amyloid Cascade Hypothesis: A Critical Review. Int J Alzheimers Dis. 2012; 2012: 369808. DM0I8RZ RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3313573/ DMIFJZD DI DMIFJZD DMIFJZD DN AFM11 DMIFJZD MI TTW640A DMIFJZD MN B-lymphocyte surface antigen B4 (CD19) DMIFJZD MT DTT DMIFJZD MA Inhibitor DMIFJZD RN A tetravalent bispecific TandAb (CD19/CD3), AFM11, efficiently recruits T cells for the potent lysis of CD19(+) tumor cells. MAbs. 2015;7(3):584-604. DMIFJZD RU https://pubmed.ncbi.nlm.nih.gov/25875246 DMIFJZD DI DMIFJZD DMIFJZD DN AFM11 DMIFJZD MI TTUN7MC DMIFJZD MN T-cell surface glycoprotein CD3 (CD3) DMIFJZD MT DTT DMIFJZD MA Inhibitor DMIFJZD RN A tetravalent bispecific TandAb (CD19/CD3), AFM11, efficiently recruits T cells for the potent lysis of CD19(+) tumor cells. MAbs. 2015;7(3):584-604. DMIFJZD RU https://pubmed.ncbi.nlm.nih.gov/25875246 DMSX24U DI DMSX24U DMSX24U DN AFO-18 DMSX24U MI TT3J5ZI DMSX24U MN Cell mediated immunity response (CMIR) DMSX24U MT DTT DMSX24U RN ClinicalTrials.gov (NCT01009762) Immunization With HIV-1 Peptides in Adjuvant for Treatment of Patients With Chronic HIV-infection. U.S. National Institutes of Health. DMSX24U RU https://clinicaltrials.gov/ct2/show/NCT01009762 DMHBUMZ DI DMHBUMZ DMHBUMZ DN AFP TCR DMHBUMZ MI TT7AKW1 DMHBUMZ MN T-cell receptor (TCR) DMHBUMZ MT DTT DMHBUMZ MA Immunomodulator DMHBUMZ RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMHBUMZ RU http://phrma-docs.phrma.org/files/dmfile/MID_Immuno-Oncology-2017_Drug-List1.pdf DMY4WVK DI DMY4WVK DMY4WVK DN AG-024322 DMY4WVK MI TTH6V3D DMY4WVK MN Cyclin-dependent kinase 1 (CDK1) DMY4WVK MT DTT DMY4WVK MA Inhibitor DMY4WVK RN Cell cycle kinases as therapeutic targets for cancer. Nat Rev Drug Discov. 2009 Jul;8(7):547-66. DMY4WVK RU https://pubmed.ncbi.nlm.nih.gov/19568282 DMY4WVK DI DMY4WVK DMY4WVK DN AG-024322 DMY4WVK MI TT7HF4W DMY4WVK MN Cyclin-dependent kinase 2 (CDK2) DMY4WVK MT DTT DMY4WVK MA Inhibitor DMY4WVK RN Cell cycle kinases as therapeutic targets for cancer. Nat Rev Drug Discov. 2009 Jul;8(7):547-66. DMY4WVK RU https://pubmed.ncbi.nlm.nih.gov/19568282 DMY4WVK DI DMY4WVK DMY4WVK DN AG-024322 DMY4WVK MI TT0PG8F DMY4WVK MN Cyclin-dependent kinase 4 (CDK4) DMY4WVK MT DTT DMY4WVK MA Inhibitor DMY4WVK RN Cell cycle kinases as therapeutic targets for cancer. Nat Rev Drug Discov. 2009 Jul;8(7):547-66. DMY4WVK RU https://pubmed.ncbi.nlm.nih.gov/19568282 DMFU58V DI DMFU58V DMFU58V DN AG2034 DMFU58V MI TTCSJBZ DMFU58V MN GAR transformylase (GART) DMFU58V MT DTT DMFU58V MA Modulator DMFU58V RN Phase I study of AG2034, a targeted GARFT inhibitor, administered once every 3 weeks. Cancer Chemother Pharmacol. 2000;45(5):423-7. DMFU58V RU https://pubmed.ncbi.nlm.nih.gov/10803927 DMYTJG7 DI DMYTJG7 DMYTJG7 DN AG-270 DMYTJG7 MI TTSMPXQ DMYTJG7 MN S-adenosylmethionine synthase type-2 (MAT2A) DMYTJG7 MT DTT DMYTJG7 MA Inhibitor DMYTJG7 RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMYTJG7 RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DMZTMEJ DI DMZTMEJ DMZTMEJ DN AG-270 DMZTMEJ MI TTSMPXQ DMZTMEJ MN S-adenosylmethionine synthase type-2 (MAT2A) DMZTMEJ MT DTT DMZTMEJ MA Inhibitor DMZTMEJ RN Discovery of AG-270, a First-in-Class Oral MAT2A Inhibitor for the Treatment of Tumors with Homozygous MTAP Deletion. J Med Chem. 2021 Apr 22;64(8):4430-4449. DMZTMEJ RU https://pubmed.ncbi.nlm.nih.gov/33829783 DM7PLMJ DI DM7PLMJ DM7PLMJ DN AG-707 DM7PLMJ MI TTHYBIX DM7PLMJ MN Heat shock protein 70 (HSP70) DM7PLMJ MT DTT DM7PLMJ MA Modulator DM7PLMJ RN A heat shock protein based polyvalent vaccine targeting HSV-2: CD4(+) and CD8(+) cellular immunity and protective efficacy. Vaccine. 2011 Nov 3;29(47):8530-41. DM7PLMJ RU https://pubmed.ncbi.nlm.nih.gov/21767588 DMV6JFK DI DMV6JFK DMV6JFK DN AGEN1181 DMV6JFK MI TTI2S1D DMV6JFK MN Cytotoxic T-lymphocyte protein 4 (CTLA-4) DMV6JFK MT DTT DMV6JFK MA Inhibitor DMV6JFK RN Clinical pipeline report, company report or official report of Agenus. DMV6JFK RU https://agenusbio.com/agen1181-second-generation-anti-ctla-4/ DMAXVZ1 DI DMAXVZ1 DMAXVZ1 DN AGEN2373 DMAXVZ1 MI TTPW9LJ DMAXVZ1 MN Co-stimulatory molecule 4-1BB (CD137) DMAXVZ1 MT DTT DMAXVZ1 MA Activator DMAXVZ1 RN Clinical pipeline report, company report or official report of Agenus. DMAXVZ1 RU https://agenusbio.com/agen2373-alpha-cd137/ DMVMIBY DI DMVMIBY DMVMIBY DN AGG-523 DMVMIBY MI TTXSU2Y DMVMIBY MN Aggrecanase (ADAMTS5) DMVMIBY MT DTT DMVMIBY MA Inhibitor DMVMIBY RN Elevated aggrecanase activity in a rat model of joint injury is attenuated by an aggrecanase specific inhibitor. Osteoarthritis Cartilage. 2011 Mar;19(3):315-23. DMVMIBY RU https://pubmed.ncbi.nlm.nih.gov/21163358 DMVHPOX DI DMVHPOX DMVHPOX DN AGN-242266 DMVHPOX MI TTS4UGC DMVHPOX MN Farnesoid X-activated receptor (FXR) DMVHPOX MT DTT DMVHPOX MA Agonist DMVHPOX RN Clinical pipeline report, company report or official report of AbbVie. DMVHPOX RU https://www.abbvie.com/our-science/pipeline/agn-242266-fxr-agonist.html DMU21JF DI DMU21JF DMU21JF DN AGS-009 DMU21JF MI TT95SOA DMU21JF MN Interferon alpha (IFNA) DMU21JF MT DTT DMU21JF RN Emerging Therapies for Systemic Lupus Erythematosus - Focus on Targeting Interferon-alpha. Clin Immunol. 2012 June; 143(3): 210-221. DMU21JF RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3358492/ DMDUIO4 DI DMDUIO4 DMDUIO4 DN AGS-348 DMDUIO4 MI TTABNSJ DMDUIO4 MN Pyruvate kinase (PK) DMDUIO4 MT DTT DMDUIO4 MA Modulator DMDUIO4 RN Clinical pipeline report, company report or official report of Agios Pharmaceuticals. DMDUIO4 RU http://investor.agios.com/phoenix.zhtml?c=251862&p=irol-newsArticle&ID=1919588 DML79KE DI DML79KE DML79KE DN AGT-182 DML79KE MI TTCBFJO DML79KE MN Insulin receptor (INSR) DML79KE MT DTT DML79KE RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1800). DML79KE RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1800 DMHMT49 DI DMHMT49 DMHMT49 DN AI3-23606 DMHMT49 MI DEAN5EW DMHMT49 MN Nitroreductase (NTR) DMHMT49 MT DME DMHMT49 MA Metabolism DMHMT49 RN Overexpression, isotopic labeling, and spectral characterization of Enterobacter cloacae nitroreductase. Protein Expr Purif. 1998 Jun;13(1):53-60. DMHMT49 RU https://pubmed.ncbi.nlm.nih.gov/9631515 DMHMT49 DI DMHMT49 DMHMT49 DN AI3-23606 DMHMT49 MI DEX5D46 DMHMT49 MN Oxygen-insensitive NADPH nitroreductase A (nfsA) DMHMT49 MT DME DMHMT49 MA Metabolism DMHMT49 RN Delamanid is not metabolized by Salmonella or human nitroreductases: a possible mechanism for the lack of mutagenicity. Regul Toxicol Pharmacol. 2017 Mar;84:1-8. DMHMT49 RU https://pubmed.ncbi.nlm.nih.gov/27988333 DMHMT49 DI DMHMT49 DMHMT49 DN AI3-23606 DMHMT49 MI DEOWDK1 DMHMT49 MN Oxygen-insensitive NADPH nitroreductase B (nfsB) DMHMT49 MT DME DMHMT49 MA Metabolism DMHMT49 RN Delamanid is not metabolized by Salmonella or human nitroreductases: a possible mechanism for the lack of mutagenicity. Regul Toxicol Pharmacol. 2017 Mar;84:1-8. DMHMT49 RU https://pubmed.ncbi.nlm.nih.gov/27988333 DMHMT49 DI DMHMT49 DMHMT49 DN AI3-23606 DMHMT49 MI DEKVGPX DMHMT49 MN Retro-nitroreductase (rNR) DMHMT49 MT DME DMHMT49 MA Metabolism DMHMT49 RN Retro-nitroreductase, a putative evolutionary precursor to Enterobacter cloacae strain 96-3 nitroreductase. Antioxid Redox Signal. 2001 Oct;3(5):747-55. DMHMT49 RU https://pubmed.ncbi.nlm.nih.gov/11761325 DMDA1UB DI DMDA1UB DMDA1UB DN AI-850 DMDA1UB MI TTJGNVC DMDA1UB MN Apoptosis regulator Bcl-2 (BCL-2) DMDA1UB MT DTT DMDA1UB MA Modulator DMDA1UB RN Intravenous hydrophobic drug delivery: a porous particle formulation of paclitaxel (AI-850). Pharm Res. 2005 Mar;22(3):347-55. DMDA1UB RU https://pubmed.ncbi.nlm.nih.gov/15835739 DMDA1UB DI DMDA1UB DMDA1UB DN AI-850 DMDA1UB MI TT63KYR DMDA1UB MN Tubulin beta-1 chain (TUBB1) DMDA1UB MT DTT DMDA1UB MA Modulator DMDA1UB RN Intravenous hydrophobic drug delivery: a porous particle formulation of paclitaxel (AI-850). Pharm Res. 2005 Mar;22(3):347-55. DMDA1UB RU https://pubmed.ncbi.nlm.nih.gov/15835739 DMSPBOW DI DMSPBOW DMSPBOW DN AIC100 DMSPBOW MI TTCT6F7 DMSPBOW MN Intercellular adhesion molecule ICAM-1 (ICAM1) DMSPBOW MT DTT DMSPBOW RN Clinical pipeline report, company report or official report of AffyImmune Therapeutics. DMSPBOW RU https://affyimmune.com/pipeline/ DMNHBMC DI DMNHBMC DMNHBMC DN AIC-292 DMNHBMC MI TT84ETX DMNHBMC MN Human immunodeficiency virus Reverse transcriptase (HIV RT) DMNHBMC MT DTT DMNHBMC MA Inhibitor DMNHBMC RN In vitro and in vivo activities of AIC292, a novel HIV-1 nonnucleoside reverse transcriptase inhibitor. Antimicrob Agents Chemother. 2013 Nov;57(11):5320-9. DMNHBMC RU https://pubmed.ncbi.nlm.nih.gov/23959304 DMW9ZFS DI DMW9ZFS DMW9ZFS DN AIKO-150 DMW9ZFS MI TT27RFC DMW9ZFS MN Opioid receptor delta (OPRD1) DMW9ZFS MT DTT DMW9ZFS MA Inhibitor DMW9ZFS RN Syntheses and opioid receptor binding properties of carboxamido-substituted opioids. Bioorg Med Chem Lett. 2009 Jan 1;19(1):203-8. DMW9ZFS RU https://pubmed.ncbi.nlm.nih.gov/19027293 DMW9ZFS DI DMW9ZFS DMW9ZFS DN AIKO-150 DMW9ZFS MI TTQW87Y DMW9ZFS MN Opioid receptor kappa (OPRK1) DMW9ZFS MT DTT DMW9ZFS MA Inhibitor DMW9ZFS RN Syntheses and opioid receptor binding properties of carboxamido-substituted opioids. Bioorg Med Chem Lett. 2009 Jan 1;19(1):203-8. DMW9ZFS RU https://pubmed.ncbi.nlm.nih.gov/19027293 DMW9ZFS DI DMW9ZFS DMW9ZFS DN AIKO-150 DMW9ZFS MI TTKWM86 DMW9ZFS MN Opioid receptor mu (MOP) DMW9ZFS MT DTT DMW9ZFS MA Antagonist DMW9ZFS RN Clinical pipeline report, company report or official report of signaturerx. DMW9ZFS RU http://www.signaturerx.com/view.cfm/59/Abuse-Resistant-Opioids DMHCBI0 DI DMHCBI0 DMHCBI0 DN AIP-303 DMHCBI0 MI TT6EO5L DMHCBI0 MN Erbb2 tyrosine kinase receptor (HER2) DMHCBI0 MT DTT DMHCBI0 RN Clinical pipeline report, company report or official report of Adagene. DMHCBI0 RU https://www.advancedinnovativepartners.com/technology DM6PN4H DI DM6PN4H DM6PN4H DN AjvW2 DM6PN4H MI TT0IHXV DM6PN4H MN DNA topoisomerase II (TOP2) DM6PN4H MT DTT DM6PN4H MA Inhibitor DM6PN4H RN The catalytic DNA topoisomerase II inhibitor ICRF-193 and all-trans retinoic acid cooperatively induce granulocytic differentiation of acute promyelocytic leukemia cells: candidate drugs for chemo-differentiation therapy against acute promyelocytic leukemia. Exp Hematol. 2002 Nov;30(11):1273-82. DM6PN4H RU https://pubmed.ncbi.nlm.nih.gov/12423680 DM6PN4H DI DM6PN4H DM6PN4H DN AjvW2 DM6PN4H MI TT38RM1 DM6PN4H MN Glycoprotein IIb/IIIa receptor (GPIIb/IIIa) DM6PN4H MT DTT DM6PN4H RN Novel approaches to the treatment of thrombosis. Trends Pharmacol Sci. 2002 Jan;23(1):25-32. DM6PN4H RU https://pubmed.ncbi.nlm.nih.gov/11804648 DM4FOX0 DI DM4FOX0 DM4FOX0 DN AK107 DM4FOX0 MI TTV8N19 DM4FOX0 MN Immune checkpoint (ICH) DM4FOX0 MT DTT DM4FOX0 MA Inhibitor DM4FOX0 RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DM4FOX0 RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DM9JU8L DI DM9JU8L DM9JU8L DN AKP-501 DM9JU8L MI TT13GFV DM9JU8L MN Follicle stimulating hormone (FSHB) DM9JU8L MT DTT DM9JU8L MA Modulator DM9JU8L RN AKR-501 (YM477) a novel orally-active thrombopoietin receptor agonist. Eur J Haematol. 2009 Apr;82(4):247-54. DM9JU8L RU https://pubmed.ncbi.nlm.nih.gov/19183407 DMHD615 DI DMHD615 DMHD615 DN ALB-109564(a) DMHD615 MI TTYFKSZ DMHD615 MN Tubulin beta (TUBB) DMHD615 MT DTT DMHD615 MA Modulator DMHD615 RN 2010 ASCO Annual Meeting DMHD615 RU http://meetinglibrary.asco.org/content/41250-74 DMYTIP4 DI DMYTIP4 DMYTIP4 DN Aleplasinin DMYTIP4 MI TT5QA2I DMYTIP4 MN Plasminogen activator inhibitor (PAI) DMYTIP4 MT DTT DMYTIP4 MA Inhibitor DMYTIP4 RN CN patent application no. 102046168, Pai-1 expression and activity inhibitors for the treatment of ocular disorders. DMYTIP4 RU http://www.google.com/patents/CN102046168A?cl=en DMXMK5S DI DMXMK5S DMXMK5S DN Alfa-interferon DMXMK5S MI TTMQB37 DMXMK5S MN Interferon alpha/beta receptor 2 (IFNAR2) DMXMK5S MT DTT DMXMK5S MA Stimulator DMXMK5S RN New drugs in development for the treatment of endometriosis. Expert Opin Investig Drugs. 2008 Aug;17(8):1187-202. DMXMK5S RU https://pubmed.ncbi.nlm.nih.gov/18616415 DMGIAND DI DMGIAND DMGIAND DN ALLO-501 DMGIAND MI TTW640A DMGIAND MN B-lymphocyte surface antigen B4 (CD19) DMGIAND MT DTT DMGIAND RN Clinical pipeline report, company report or official report of Allogene Therapeutics. DMGIAND RU https://www.allogene.com/pipeline#all0-501/501A DMHE3MD DI DMHE3MD DMHE3MD DN ALLO-715 DMHE3MD MI TTZ3P4W DMHE3MD MN B-cell maturation protein (TNFRSF17) DMHE3MD MT DTT DMHE3MD RN Clinical pipeline report, company report or official report of Allogene Therapeutics. DMHE3MD RU https://www.allogene.com/pipeline#all0-501/501A DMCYV26 DI DMCYV26 DMCYV26 DN Allogeneic CART-19 DMCYV26 MI TTW640A DMCYV26 MN B-lymphocyte surface antigen B4 (CD19) DMCYV26 MT DTT DMCYV26 MA CAR-T-Cell-Therapy DMCYV26 RN ClinicalTrials.gov (NCT02799550) Allogeneic CART-19 for Elderly Relapsed/Refractory CD19+ ALL DMCYV26 RU https://clinicaltrials.gov/ct2/show/NCT02799550 DM4RHM5 DI DM4RHM5 DM4RHM5 DN Allogeneic CART-33 DM4RHM5 MI TTJVYO3 DM4RHM5 MN Myeloid cell surface antigen CD33 (CD33) DM4RHM5 MT DTT DM4RHM5 MA CAR-T-Cell-Therapy DM4RHM5 RN ClinicalTrials.gov (NCT02799680) Allogeneic CART-33 for Relapsed/Refractory CD33+ AML DM4RHM5 RU https://clinicaltrials.gov/ct2/show/NCT02799680 DMCSEUY DI DMCSEUY DMCSEUY DN ALN-TTR01 DMCSEUY MI TTPOYU7 DMCSEUY MN Transthyretin messenger RNA (TTR mRNA) DMCSEUY MT DTT DMCSEUY MA Inhibitor DMCSEUY RN Safety and efficacy of RNAi therapy for transthyretin amyloidosis. N Engl J Med. 2013 Aug 29;369(9):819-29. DMCSEUY RU https://pubmed.ncbi.nlm.nih.gov/23984729 DM89DHO DI DM89DHO DM89DHO DN ALN-VSP DM89DHO MI TTBGTCW DM89DHO MN Kinesin spindle messenger RNA (KIF11 mRNA) DM89DHO MT DTT DM89DHO RN Clinical pipeline report, company report or official report of Alnylam Pharmaceuticals, Inc (2011). DM89DHO RU http://www.alnylam.com/Programs-and-Pipeline/index.php DMGFVYL DI DMGFVYL DMGFVYL DN ALO-1567 DMGFVYL MI TTFBNVI DMGFVYL MN Aldose reductase (AKR1B1) DMGFVYL MT DTT DMGFVYL MA Inhibitor DMGFVYL RN Metabolism of the aldose reductase inhibitor ALO1567 in man. Br J Clin Pharmacol. 1991 Aug;32(2):221-7. DMGFVYL RU https://pubmed.ncbi.nlm.nih.gov/1931471 DMIEKTF DI DMIEKTF DMIEKTF DN Alofanib DMIEKTF MI TTGJVQM DMIEKTF MN Fibroblast growth factor receptor 2 (FGFR2) DMIEKTF MT DTT DMIEKTF MA Inhibitor DMIEKTF RN Corrigendum to 'Targeting FGFR2 with alofanib (RPT835) shows potent activity in tumour models' [Eur J Cancer 61 (2016) 20-28]. Eur J Cancer. 2017 Jan;70:156. DMIEKTF RU https://pubmed.ncbi.nlm.nih.gov/27919550 DMP9VXQ DI DMP9VXQ DMP9VXQ DN ALPHA-FMH DMP9VXQ MI TTV9GOF DMP9VXQ MN Histidine decarboxylase (HDC) DMP9VXQ MT DTT DMP9VXQ MA Modulator DMP9VXQ RN Alpha-Fluoromethylhistidine. Kinetics of uptake and inhibition of histamine synthesis in basophil (2H3) cell cultures. Mol Pharmacol. 1985 Aug;28(2):191-9. DMP9VXQ RU https://pubmed.ncbi.nlm.nih.gov/2410770 DMBVM1Q DI DMBVM1Q DMBVM1Q DN AlphaMedix DMBVM1Q MI TTOMNR9 DMBVM1Q MN Somatostatin receptor (SSTR) DMBVM1Q MT DTT DMBVM1Q MA Activator DMBVM1Q RN Clinical pipeline report, company report or official report of Orano Med. DMBVM1Q RU https://www.oranomed.com/en/pipeline DMTD4EF DI DMTD4EF DMTD4EF DN ALPN-202 DMTD4EF MI TTI2S1D DMTD4EF MN Cytotoxic T-lymphocyte protein 4 (CTLA-4) DMTD4EF MT DTT DMTD4EF MA Inhibitor DMTD4EF RN Clinical pipeline report, company report or official report of Alpine Immune Sciences. DMTD4EF RU https://www.alpineimmunesciences.com/wp-content/uploads/2020/06/ALPN-202_AACR20_NEON-1_TIP.pdf DMTD4EF DI DMTD4EF DMTD4EF DN ALPN-202 DMTD4EF MI TT8ZLTI DMTD4EF MN Programmed cell death 1 ligand 1 (PD-L1) DMTD4EF MT DTT DMTD4EF MA Inhibitor DMTD4EF RN Clinical pipeline report, company report or official report of Alpine Immune Sciences. DMTD4EF RU https://www.alpineimmunesciences.com/wp-content/uploads/2020/06/ALPN-202_AACR20_NEON-1_TIP.pdf DMUJCBT DI DMUJCBT DMUJCBT DN Altiratinib DMUJCBT MI TT9VGXW DMUJCBT MN Angiopoietin 1 receptor (TEK) DMUJCBT MT DTT DMUJCBT MA Inhibitor DMUJCBT RN Clinical pipeline report, company report or official report of Deciphera Pharmaceuticals. DMUJCBT RU http://www.deciphera.com/article/deciphera-pharmaceuticals-announces-initiation-phase-1-cancer-trial-altiratinib-dcc-2701 DMUJCBT DI DMUJCBT DMUJCBT DN Altiratinib DMUJCBT MI TTXABCW DMUJCBT MN NT-3 growth factor receptor (TrkC) DMUJCBT MT DTT DMUJCBT MA Inhibitor DMUJCBT RN Tropomyosin receptor kinase inhibitors: an updated patent review for 2010-2016 - Part I.Expert Opin Ther Pat. 2017 Jun;27(6):733-751. DMUJCBT RU https://www.ncbi.nlm.nih.gov/pubmed/28270010 DMUJCBT DI DMUJCBT DMUJCBT DN Altiratinib DMUJCBT MI TTNDSF4 DMUJCBT MN Proto-oncogene c-Met (MET) DMUJCBT MT DTT DMUJCBT MA Inhibitor DMUJCBT RN Clinical pipeline report, company report or official report of Deciphera Pharmaceuticals. DMUJCBT RU http://www.deciphera.com/article/deciphera-pharmaceuticals-announces-initiation-phase-1-cancer-trial-altiratinib-dcc-2701 DMUJCBT DI DMUJCBT DMUJCBT DN Altiratinib DMUJCBT MI TTTDVOJ DMUJCBT MN Tropomyosin-related kinase A (TrkA) DMUJCBT MT DTT DMUJCBT MA Inhibitor DMUJCBT RN Tropomyosin receptor kinase inhibitors: an updated patent review for 2010-2016 - Part I.Expert Opin Ther Pat. 2017 Jun;27(6):733-751. DMUJCBT RU https://www.ncbi.nlm.nih.gov/pubmed/28270010 DMUJCBT DI DMUJCBT DMUJCBT DN Altiratinib DMUJCBT MI TTUTJGQ DMUJCBT MN Vascular endothelial growth factor receptor 2 (KDR) DMUJCBT MT DTT DMUJCBT MA Antagonist DMUJCBT RN Clinical pipeline report, company report or official report of Deciphera Pharmaceuticals. DMUJCBT RU http://www.deciphera.com/article/deciphera-pharmaceuticals-announces-initiation-phase-1-cancer-trial-altiratinib-dcc-2701 DM6KU93 DI DM6KU93 DM6KU93 DN Alvespimycin hydrochloride DM6KU93 MI TT78R5H DM6KU93 MN Heat shock protein 90 alpha (HSP90A) DM6KU93 MT DTT DM6KU93 MA Inhibitor DM6KU93 RN Stage 1 testing and pharmacodynamic evaluation of the HSP90 inhibitor alvespimycin (17-DMAG, KOS-1022) by the pediatric preclinical testing program. Pediatr Blood Cancer. 2008 Jul;51(1):34-41. DM6KU93 RU https://pubmed.ncbi.nlm.nih.gov/18260120 DMBGI74 DI DMBGI74 DMBGI74 DN ALX-0141 DMBGI74 MI TT9E8HR DMBGI74 MN Osteoclast differentiation factor (ODF) DMBGI74 MT DTT DMBGI74 MA Inhibitor DMBGI74 RN Clinical pipeline report, company report or official report of Ablynx. DMBGI74 RU http://www.ablynx.com/rd-portfolio/clinical-programmes/alx-0141/ DMIRYM8 DI DMIRYM8 DMIRYM8 DN ALX-0651 DMIRYM8 MI TTBID49 DMIRYM8 MN C-X-C chemokine receptor type 4 (CXCR4) DMIRYM8 MT DTT DMIRYM8 MA Inhibitor DMIRYM8 RN Therapeutic antibodies directed at G protein-coupled receptors. MAbs. 2010 Nov-Dec; 2(6): 594-606. DMIRYM8 RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3011214/ DMJ8ACF DI DMJ8ACF DMJ8ACF DN ALX-0761 DMJ8ACF MI TTG0MT6 DMJ8ACF MN Interleukin-17 (IL17) DMJ8ACF MT DTT DMJ8ACF MA Modulator DMJ8ACF RN Bispecific antibodies rise again. Nat Rev Drug Discov. 2014 Nov;13(11):799-801. DMJ8ACF RU https://www.ncbi.nlm.nih.gov/pubmed/25359367 DMJ8ACF DI DMJ8ACF DMJ8ACF DN ALX-0761 DMJ8ACF MI TTVMO5W DMJ8ACF MN Interleukin-25 (IL25) DMJ8ACF MT DTT DMJ8ACF MA Modulator DMJ8ACF RN Bispecific antibodies rise again. Nat Rev Drug Discov. 2014 Nov;13(11):799-801. DMJ8ACF RU https://www.ncbi.nlm.nih.gov/pubmed/25359367 DMLJWPN DI DMLJWPN DMLJWPN DN Alx-5407 DMLJWPN MI TTHJTF7 DMLJWPN MN Glycine transporter GlyT-1 (SLC6A9) DMLJWPN MT DTT DMLJWPN MA Blocker DMLJWPN RN ALX 5407: a potent, selective inhibitor of the hGlyT1 glycine transporter. Mol Pharmacol. 2001 Dec;60(6):1414-20. DMLJWPN RU https://pubmed.ncbi.nlm.nih.gov/11723250 DMVXRYC DI DMVXRYC DMVXRYC DN AM-211 DMVXRYC MI TTQDMX5 DMVXRYC MN Prostaglandin D2 receptor 2 (PTGDR2) DMVXRYC MT DTT DMVXRYC MA Antagonist DMVXRYC RN Pharmacology of AM211, a potent and selective prostaglandin D2 receptor type 2 antagonist that is active in animal models of allergic inflammation. J Pharmacol Exp Ther. 2011 Jul;338(1):290-301. DMVXRYC RU https://pubmed.ncbi.nlm.nih.gov/21487069 DM7Z8NP DI DM7Z8NP DM7Z8NP DN AM-461 DM7Z8NP MI TTQDMX5 DM7Z8NP MN Prostaglandin D2 receptor 2 (PTGDR2) DM7Z8NP MT DTT DM7Z8NP MA Antagonist DM7Z8NP RN A novel DP2 receptor antagonist (AM-461): a patent evaluation of WO2011085033. Expert Opin Ther Pat. 2011 Dec;21(12):1931-6. DM7Z8NP RU https://pubmed.ncbi.nlm.nih.gov/22082220 DM7CD8Z DI DM7CD8Z DM7CD8Z DN AMAP-102 DM7CD8Z MI TTYSN63 DM7CD8Z MN 5-HT 2 receptor (5HT2R) DM7CD8Z MT DTT DM7CD8Z MA Antagonist DM7CD8Z RN Clinical pipeline report, company report or official report of Anamar. DM7CD8Z RU http://anamar.com/rd/project-amap102/ DMFELMQ DI DMFELMQ DMFELMQ DN AMEP DMFELMQ MI TTH4QIS DMFELMQ MN Integrin alpha-5/beta-1 (ITGA5/B1) DMFELMQ MT DTT DMFELMQ MA Modulator DMFELMQ RN Gene electrotransfer of plasmid AMEP, an integrin-targeted therapy, has antitumor and antiangiogenic action in murine B16 melanoma.Gene Ther.2015 Jul;22(7):578-90. DMFELMQ RU https://www.ncbi.nlm.nih.gov/pubmed/25781650 DMFELMQ DI DMFELMQ DMFELMQ DN AMEP DMFELMQ MI TT69TQN DMFELMQ MN Integrin alpha-V/beta-3 (ITGAV/B3) DMFELMQ MT DTT DMFELMQ MA Modulator DMFELMQ RN Gene electrotransfer of plasmid AMEP, an integrin-targeted therapy, has antitumor and antiangiogenic action in murine B16 melanoma.Gene Ther.2015 Jul;22(7):578-90. DMFELMQ RU https://www.ncbi.nlm.nih.gov/pubmed/25781650 DMKF1O2 DI DMKF1O2 DMKF1O2 DN AMG 119 DMKF1O2 MI TT1C9K6 DMKF1O2 MN Delta-like protein 3 (DLL3) DMKF1O2 MT DTT DMKF1O2 MA Inhibitor DMKF1O2 RN Clinical pipeline report, company report or official report of Amgen. DMKF1O2 RU https://www.amgenpipeline.com/ DMM0HNF DI DMM0HNF DMM0HNF DN AMG 160 DMM0HNF MI TT9G4N0 DMM0HNF MN Glutamate carboxypeptidase II (GCPII) DMM0HNF MT DTT DMM0HNF MA Inhibitor DMM0HNF RN Clinical pipeline report, company report or official report of Amgen. DMM0HNF RU https://www.amgenpipeline.com/ DMM0HNF DI DMM0HNF DMM0HNF DN AMG 160 DMM0HNF MI TTUN7MC DMM0HNF MN T-cell surface glycoprotein CD3 (CD3) DMM0HNF MT DTT DMM0HNF MA Inhibitor DMM0HNF RN Clinical pipeline report, company report or official report of Amgen. DMM0HNF RU https://www.amgenpipeline.com/ DMUETI2 DI DMUETI2 DMUETI2 DN AMG 167 DMUETI2 MI TTYRO4F DMUETI2 MN Sclerostin (SOST) DMUETI2 MT DTT DMUETI2 MA Modulator DMUETI2 RN Osteoporosis - a current view of pharmacological prevention and treatment. Drug Des Devel Ther. 2013; 7: 435-448. DMUETI2 RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3686324/ DMS72GN DI DMS72GN DMS72GN DN AMG 172 DMS72GN MI TTNCIE0 DMS72GN MN CD70 antigen (CD27-L) DMS72GN MT DTT DMS72GN MA Modulator DMS72GN RN National Cancer Institute Drug Dictionary (drug id 721679). DMS72GN RU http://www.cancer.gov/publications/dictionaries/cancer-drug?cdrid=721679 DM0Q7NO DI DM0Q7NO DM0Q7NO DN AMG 176 DM0Q7NO MI TTL53M6 DM0Q7NO MN Induced myeloid leukemia cell differentiation protein Mcl-1 (MCL1) DM0Q7NO MT DTT DM0Q7NO MA Inhibitor DM0Q7NO RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DM0Q7NO RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DMWG2K6 DI DMWG2K6 DMWG2K6 DN AMG 199 DMWG2K6 MI TTVO0JU DMWG2K6 MN Mucin-17 (MUC17) DMWG2K6 MT DTT DMWG2K6 MA Inhibitor DMWG2K6 RN Clinical pipeline report, company report or official report of Amgen. DMWG2K6 RU https://www.amgenpipeline.com/ DMWG2K6 DI DMWG2K6 DMWG2K6 DN AMG 199 DMWG2K6 MI TTUN7MC DMWG2K6 MN T-cell surface glycoprotein CD3 (CD3) DMWG2K6 MT DTT DMWG2K6 MA Inhibitor DMWG2K6 RN Clinical pipeline report, company report or official report of Amgen. DMWG2K6 RU https://www.amgenpipeline.com/ DMA1I04 DI DMA1I04 DMA1I04 DN AMG 211 DMA1I04 MI TTY6DTE DMA1I04 MN Carcinoembryonic antigen CEA (CD66e) DMA1I04 MT DTT DMA1I04 MA Immunomodulator DMA1I04 RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMA1I04 RU http://phrma-docs.phrma.org/files/dmfile/MID_Immuno-Oncology-2017_Drug-List1.pdf DMLQJ5P DI DMLQJ5P DMLQJ5P DN AMG 228 DMLQJ5P MI TTG6LA7 DMLQJ5P MN Activation-inducible TNFR family receptor (TNFRSF18) DMLQJ5P MT DTT DMLQJ5P MA Agonist DMLQJ5P RN Dose escalation results from a first-in-human, phase 1 study of glucocorticoid-induced TNF receptor-related protein agonist AMG 228 in patients with advanced solid tumors. J Immunother Cancer. 2018 Sep 25;6(1):93. DMLQJ5P RU https://pubmed.ncbi.nlm.nih.gov/30253804 DMXYCZV DI DMXYCZV DMXYCZV DN AMG 256 DMXYCZV MI TTZO9B0 DMXYCZV MN Interleukin 21 receptor (IL21R) DMXYCZV MT DTT DMXYCZV MA Agonist DMXYCZV RN Clinical pipeline report, company report or official report of Amgen. DMXYCZV RU https://www.amgenpipeline.com/ DM92YWD DI DM92YWD DM92YWD DN AMG 282 DM92YWD MI TT5MD4P DM92YWD MN Interleukin-33 (IL33) DM92YWD MT DTT DM92YWD RN Clinical pipeline report, company report or official report of Amgen. DM92YWD RU http://www.amgenpipeline.com/pipeline/ DM9P0NA DI DM9P0NA DM9P0NA DN AMG 319 DM9P0NA MI TTGBPJE DM9P0NA MN PI3-kinase delta (PIK3CD) DM9P0NA MT DTT DM9P0NA MA Inhibitor DM9P0NA RN National Cancer Institute Drug Dictionary (drug id 696292). DM9P0NA RU http://www.cancer.gov/publications/dictionaries/cancer-drug?cdrid=696292 DMC3G2E DI DMC3G2E DMC3G2E DN AMG 330 DMC3G2E MI TTJVYO3 DMC3G2E MN Myeloid cell surface antigen CD33 (CD33) DMC3G2E MT DTT DMC3G2E MA Inhibitor DMC3G2E RN Preclinical characterization of AMG 330, a CD3/CD33-bispecific T-cell-engaging antibody with potential for treatment of acute myelogenous leukemia. Mol Cancer Ther. 2014 Jun;13(6):1549-57. DMC3G2E RU https://pubmed.ncbi.nlm.nih.gov/24674885 DMC3G2E DI DMC3G2E DMC3G2E DN AMG 330 DMC3G2E MI TTUN7MC DMC3G2E MN T-cell surface glycoprotein CD3 (CD3) DMC3G2E MT DTT DMC3G2E MA Inhibitor DMC3G2E RN Preclinical characterization of AMG 330, a CD3/CD33-bispecific T-cell-engaging antibody with potential for treatment of acute myelogenous leukemia. Mol Cancer Ther. 2014 Jun;13(6):1549-57. DMC3G2E RU https://pubmed.ncbi.nlm.nih.gov/24674885 DM7CNTG DI DM7CNTG DM7CNTG DN AMG 397 DM7CNTG MI TTL53M6 DM7CNTG MN Induced myeloid leukemia cell differentiation protein Mcl-1 (MCL1) DM7CNTG MT DTT DM7CNTG MA Inhibitor DM7CNTG RN Clinical pipeline report, company report or official report of Amgen. DM7CNTG RU https://www.amgenpipeline.com/ DMVQX5K DI DMVQX5K DMVQX5K DN AMG 404 DMVQX5K MI TTNBFWK DMVQX5K MN Programmed cell death protein 1 (PD-1) DMVQX5K MT DTT DMVQX5K MA Inhibitor DMVQX5K RN ClinicalTrials.gov (NCT03853109) AMG 404 in Patients With Advanced Solid Tumors.. U.S. National Institutes of Health. DMVQX5K RU https://clinicaltrials.gov/ct2/show/NCT03853109 DMYFZLA DI DMYFZLA DMYFZLA DN AMG 420 DMYFZLA MI TTZ3P4W DMYFZLA MN B-cell maturation protein (TNFRSF17) DMYFZLA MT DTT DMYFZLA MA Inhibitor DMYFZLA RN Anti-B-Cell Maturation Antigen BiTE Molecule AMG 420 Induces Responses in Multiple Myeloma. J Clin Oncol. 2020 Mar 10;38(8):775-783. DMYFZLA RU https://pubmed.ncbi.nlm.nih.gov/31895611 DMLAP8F DI DMLAP8F DMLAP8F DN AMG 424 DMLAP8F MI TTPURFN DMLAP8F MN Cyclic ADP-ribose hydrolase 1 (CD38) DMLAP8F MT DTT DMLAP8F MA Inhibitor DMLAP8F RN Clinical pipeline report, company report or official report of Amgen. DMLAP8F RU https://www.amgenpipeline.com/ DMLAP8F DI DMLAP8F DMLAP8F DN AMG 424 DMLAP8F MI TTUN7MC DMLAP8F MN T-cell surface glycoprotein CD3 (CD3) DMLAP8F MT DTT DMLAP8F MA Inhibitor DMLAP8F RN Clinical pipeline report, company report or official report of Amgen. DMLAP8F RU https://www.amgenpipeline.com/ DMI7JO6 DI DMI7JO6 DMI7JO6 DN AMG 427 DMI7JO6 MI TTGJCWZ DMI7JO6 MN Fms-like tyrosine kinase 3 (FLT-3) DMI7JO6 MT DTT DMI7JO6 MA Inhibitor DMI7JO6 RN Clinical pipeline report, company report or official report of Amgen. DMI7JO6 RU https://www.amgenpipeline.com/ DMI7JO6 DI DMI7JO6 DMI7JO6 DN AMG 427 DMI7JO6 MI TTUN7MC DMI7JO6 MN T-cell surface glycoprotein CD3 (CD3) DMI7JO6 MT DTT DMI7JO6 MA Inhibitor DMI7JO6 RN Clinical pipeline report, company report or official report of Amgen. DMI7JO6 RU https://www.amgenpipeline.com/ DMG64PE DI DMG64PE DMG64PE DN AMG 506 DMG64PE MI TTPW9LJ DMG64PE MN Co-stimulatory molecule 4-1BB (CD137) DMG64PE MT DTT DMG64PE MA Inhibitor DMG64PE RN Clinical pipeline report, company report or official report of Amgen. DMG64PE RU https://www.amgenpipeline.com/ DMG64PE DI DMG64PE DMG64PE DN AMG 506 DMG64PE MI TTGPQ0F DMG64PE MN Prolyl endopeptidase FAP (FAP) DMG64PE MT DTT DMG64PE MA Inhibitor DMG64PE RN Clinical pipeline report, company report or official report of Amgen. DMG64PE RU https://www.amgenpipeline.com/ DM2POGY DI DM2POGY DM2POGY DN AMG 509 DM2POGY MI TT9E64S DM2POGY MN Metalloreductase STEAP1 (STEAP1) DM2POGY MT DTT DM2POGY MA Inhibitor DM2POGY RN Clinical pipeline report, company report or official report of Amgen. DM2POGY RU https://www.amgenpipeline.com/ DMNEFQ6 DI DMNEFQ6 DMNEFQ6 DN AMG 529 DMNEFQ6 MI TTYM94H DMNEFQ6 MN Asialoglycoprotein receptor 1 (ASGR1) DMNEFQ6 MT DTT DMNEFQ6 MA Inhibitor DMNEFQ6 RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMNEFQ6 RU http://phrma-docs.phrma.org/files/dmfile/2018_Heart-Disease-and-Stroke_MID-Drug-List.pdf DMQ0N5Z DI DMQ0N5Z DMQ0N5Z DN AMG 562 DMQ0N5Z MI TTW640A DMQ0N5Z MN B-lymphocyte surface antigen B4 (CD19) DMQ0N5Z MT DTT DMQ0N5Z MA Inhibitor DMQ0N5Z RN Clinical pipeline report, company report or official report of Amgen. DMQ0N5Z RU https://www.amgenpipeline.com/ DMRMC7U DI DMRMC7U DMRMC7U DN AMG 579 DMRMC7U MI TTJW4LU DMRMC7U MN Phosphodiesterase 10A (PDE10) DMRMC7U MT DTT DMRMC7U MA Inhibitor DMRMC7U RN Discovery of clinical candidate 1-(4-(3-(4-(1H-benzo[d]imidazole-2-carbonyl)phenoxy)pyrazin-2-yl)piperidin-1-yl)ethanone (AMG 579), a potent, selective, and efficacious inhibitor of phosphodiesterase10A (PDE10A). J Med Chem. 2014 Aug 14;57(15):6632-41. DMRMC7U RU https://pubmed.ncbi.nlm.nih.gov/25062128 DMJFKW3 DI DMJFKW3 DMJFKW3 DN AMG 595 DMJFKW3 MI TTGKNB4 DMJFKW3 MN Epidermal growth factor receptor (EGFR) DMJFKW3 MT DTT DMJFKW3 MA Modulator DMJFKW3 RN AMG 595, an Anti-EGFRvIII Antibody-Drug Conjugate, Induces Potent Antitumor Activity against EGFRvIII-Expressing Glioblastoma. Mol Cancer Ther. 2015 Jul;14(7):1614-24. DMJFKW3 RU https://pubmed.ncbi.nlm.nih.gov/25931519 DM4G1SP DI DM4G1SP DM4G1SP DN AMG 596 DM4G1SP MI TTZ6B2I DM4G1SP MN Epidermal growth factor receptor variant III (EGFR vIII) DM4G1SP MT DTT DM4G1SP MA Inhibitor DM4G1SP RN Clinical pipeline report, company report or official report of Amgen. DM4G1SP RU https://www.amgenpipeline.com/ DM4G1SP DI DM4G1SP DM4G1SP DN AMG 596 DM4G1SP MI TTUN7MC DM4G1SP MN T-cell surface glycoprotein CD3 (CD3) DM4G1SP MT DTT DM4G1SP MA Inhibitor DM4G1SP RN Clinical pipeline report, company report or official report of Amgen. DM4G1SP RU https://www.amgenpipeline.com/ DMA3B9T DI DMA3B9T DMA3B9T DN AMG 673 DMA3B9T MI TTJVYO3 DMA3B9T MN Myeloid cell surface antigen CD33 (CD33) DMA3B9T MT DTT DMA3B9T MA Inhibitor DMA3B9T RN Clinical pipeline report, company report or official report of Amgen. DMA3B9T RU https://www.amgenpipeline.com/ DMA3B9T DI DMA3B9T DMA3B9T DN AMG 673 DMA3B9T MI TTUN7MC DMA3B9T MN T-cell surface glycoprotein CD3 (CD3) DMA3B9T MT DTT DMA3B9T MA Inhibitor DMA3B9T RN Clinical pipeline report, company report or official report of Amgen. DMA3B9T RU https://www.amgenpipeline.com/ DM6IT3M DI DM6IT3M DM6IT3M DN AMG 701 DM6IT3M MI TTZ3P4W DM6IT3M MN B-cell maturation protein (TNFRSF17) DM6IT3M MT DTT DM6IT3M MA Inhibitor DM6IT3M RN Clinical pipeline report, company report or official report of Amgen. DM6IT3M RU https://www.amgenpipeline.com/ DM6IT3M DI DM6IT3M DM6IT3M DN AMG 701 DM6IT3M MI TTUN7MC DM6IT3M MN T-cell surface glycoprotein CD3 (CD3) DM6IT3M MT DTT DM6IT3M MA Inhibitor DM6IT3M RN Clinical pipeline report, company report or official report of Amgen. DM6IT3M RU https://www.amgenpipeline.com/ DMLYP2N DI DMLYP2N DMLYP2N DN AMG 757 DMLYP2N MI TT1C9K6 DMLYP2N MN Delta-like protein 3 (DLL3) DMLYP2N MT DTT DMLYP2N MA Inhibitor DMLYP2N RN Clinical pipeline report, company report or official report of Amgen. DMLYP2N RU https://www.amgenpipeline.com/ DMLYP2N DI DMLYP2N DMLYP2N DN AMG 757 DMLYP2N MI TTUN7MC DMLYP2N MN T-cell surface glycoprotein CD3 (CD3) DMLYP2N MT DTT DMLYP2N MA Inhibitor DMLYP2N RN Clinical pipeline report, company report or official report of Amgen. DMLYP2N RU https://www.amgenpipeline.com/ DMTGZN8 DI DMTGZN8 DMTGZN8 DN AMG 780 DMTGZN8 MI TTWNQ1T DMTGZN8 MN Angiopoietin-1 (ANGPT1) DMTGZN8 MT DTT DMTGZN8 MA Modulator DMTGZN8 RN Development and preclinical testing of AMG 780, a fully human antibody targeting angiopoietin 1 (Ang1) and angiopoietin 2 (Ang2). Cancer Research. 10/2014; 74(19 Supplement):1022-1022. DMTGZN8 RU http://cancerres.aacrjournals.org/content/74/19_Supplement/1022 DMEIMBP DI DMEIMBP DMEIMBP DN AMG 811 DMEIMBP MI TT93WF5 DMEIMBP MN Interferon-gamma (IFNG) DMEIMBP MT DTT DMEIMBP MA Modulator DMEIMBP RN Pharmacokinetic and pharmacodynamic relationship of AMG 811, an anti-IFN-gamma IgG1 monoclonal antibody, in patients with systemic lupus erythematosus. Pharm Res. 2015 Feb;32(2):640-53. DMEIMBP RU https://pubmed.ncbi.nlm.nih.gov/25213774 DMB6Q19 DI DMB6Q19 DMB6Q19 DN AMG 820 DMB6Q19 MI TT731LW DMB6Q19 MN Colony stimulating factor-1 receptor (CSF-1R) DMB6Q19 MT DTT DMB6Q19 MA Modulator DMB6Q19 RN Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41. DMB6Q19 RU https://www.ncbi.nlm.nih.gov/pubmed/15950434 DMB6Q19 DI DMB6Q19 DMB6Q19 DN AMG 820 DMB6Q19 MI TTC70AJ DMB6Q19 MN Granulocyte colony-stimulating factor receptor (G-CSF-R) DMB6Q19 MT DTT DMB6Q19 MA Inhibitor DMB6Q19 RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMB6Q19 RU http://phrma-docs.phrma.org/files/dmfile/MID_Immuno-Oncology-2017_Drug-List1.pdf DM1FJ9C DI DM1FJ9C DM1FJ9C DN AMG 876 DM1FJ9C MI TTUPB12 DM1FJ9C MN Measles virus Fusion glycoprotein (MeV F) DM1FJ9C MT DTT DM1FJ9C MA Modulator DM1FJ9C RN Clinical pipeline report, company report or official report of Amgen. DM1FJ9C RU http://www.amgenpipeline.com/pipeline/ DMASGXJ DI DMASGXJ DMASGXJ DN AMG 900 DMASGXJ MI TTPS3C0 DMASGXJ MN Aurora kinase A (AURKA) DMASGXJ MT DTT DMASGXJ MA Modulator DMASGXJ RN Preclinical evaluation of AMG 900, a novel potent and highly selective pan-aurora kinase inhibitor with activity in taxane-resistant tumor cell lines. Cancer Res. 2010 Dec 1;70(23):9846-54. DMASGXJ RU https://pubmed.ncbi.nlm.nih.gov/20935223 DMASGXJ DI DMASGXJ DMASGXJ DN AMG 900 DMASGXJ MI TT5LS6T DMASGXJ MN Aurora kinase B (AURKB) DMASGXJ MT DTT DMASGXJ MA Modulator DMASGXJ RN Preclinical evaluation of AMG 900, a novel potent and highly selective pan-aurora kinase inhibitor with activity in taxane-resistant tumor cell lines. Cancer Res. 2010 Dec 1;70(23):9846-54. DMASGXJ RU https://pubmed.ncbi.nlm.nih.gov/20935223 DMASGXJ DI DMASGXJ DMASGXJ DN AMG 900 DMASGXJ MI TTLYXIT DMASGXJ MN Aurora kinase C (AURKC) DMASGXJ MT DTT DMASGXJ MA Modulator DMASGXJ RN Preclinical evaluation of AMG 900, a novel potent and highly selective pan-aurora kinase inhibitor with activity in taxane-resistant tumor cell lines. Cancer Res. 2010 Dec 1;70(23):9846-54. DMASGXJ RU https://pubmed.ncbi.nlm.nih.gov/20935223 DMCG7XL DI DMCG7XL DMCG7XL DN AMG 910 DMCG7XL MI TT6PKBX DMCG7XL MN Claudin-18 (CLDN18) DMCG7XL MT DTT DMCG7XL MA Inhibitor DMCG7XL RN Clinical pipeline report, company report or official report of Amgen. DMCG7XL RU https://www.amgenpipeline.com/ DMCG7XL DI DMCG7XL DMCG7XL DN AMG 910 DMCG7XL MI TTUN7MC DMCG7XL MN T-cell surface glycoprotein CD3 (CD3) DMCG7XL MT DTT DMCG7XL MA Inhibitor DMCG7XL RN Clinical pipeline report, company report or official report of Amgen. DMCG7XL RU https://www.amgenpipeline.com/ DMZQ2DK DI DMZQ2DK DMZQ2DK DN AMG 986 DMZQ2DK MI TTJ8E43 DMZQ2DK MN Apelin receptor (APLNR) DMZQ2DK MT DTT DMZQ2DK MA Agonist DMZQ2DK RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMZQ2DK RU http://phrma-docs.phrma.org/files/dmfile/2018_Heart-Disease-and-Stroke_MID-Drug-List.pdf DMEHOVF DI DMEHOVF DMEHOVF DN AMG-139 DMEHOVF MI TTC1GLB DMEHOVF MN Interleukin-23 (IL23) DMEHOVF MT DTT DMEHOVF RN Preclinical development of AMG 139, a human antibody specifically targeting IL-23. Br J Pharmacol. 2015 Jan;172(1):159-72. DMEHOVF RU https://pubmed.ncbi.nlm.nih.gov/25205227 DMSHK23 DI DMSHK23 DMSHK23 DN AMG-191 DMSHK23 MI TTX41N9 DMSHK23 MN Tyrosine-protein kinase Kit (KIT) DMSHK23 MT DTT DMSHK23 MA Inhibitor DMSHK23 RN Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800029529) DMSHK23 RU http://adisinsight.springer.com/drugs/800029529 DMJQDUC DI DMJQDUC DMJQDUC DN Aminoguanidine DMJQDUC MI TTFZYTO DMJQDUC MN C-C chemokine receptor type 2 (CCR2) DMJQDUC MT DTT DMJQDUC MA Antagonist DMJQDUC RN Incyte Announces Second Quarter 2005 Financial Results; Reports Positive Phase IIb Results for Reverset in Treatment-Experienced HIV Patients. Incyte Corporation. 2005. DMJQDUC RU http://www.aegis.com/news/bw/2005/BW050801.html DMJQDUC DI DMJQDUC DMJQDUC DN Aminoguanidine DMJQDUC MI TTF10I9 DMJQDUC MN Nitric-oxide synthase inducible (NOS2) DMJQDUC MT DTT DMJQDUC MA Inhibitor DMJQDUC RN Inhibitory effects of aminoguanidine on thyroid follicular carcinoma development in inflamed capsular regions of rats treated with sulfadimethoxine... Cancer Sci. 2009 Oct;100(10):1794-800. DMJQDUC RU https://pubmed.ncbi.nlm.nih.gov/19572977 DMH9M62 DI DMH9M62 DMH9M62 DN AMP-224 DMH9M62 MI TTNBFWK DMH9M62 MN Programmed cell death protein 1 (PD-1) DMH9M62 MT DTT DMH9M62 MA Modulator DMH9M62 RN National Cancer Institute Drug Dictionary (drug id 700595). DMH9M62 RU http://www.cancer.gov/publications/dictionaries/cancer-drug?cdrid=700595 DMT27PA DI DMT27PA DMT27PA DN AMV564 DMT27PA MI TTJVYO3 DMT27PA MN Myeloid cell surface antigen CD33 (CD33) DMT27PA MT DTT DMT27PA MA Modulator DMT27PA RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMT27PA RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DMR35U4 DI DMR35U4 DMR35U4 DN AMXT1501 DMR35U4 MI TTJR4Z5 DMR35U4 MN Polyamine transport (Poly trans) DMR35U4 MT DTT DMR35U4 MA Inhibitor DMR35U4 RN AMXT-1501, a novel polyamine transport inhibitor, synergizes with DFMO in inhibiting neuroblastoma cell proliferation by targeting both ornithine decarboxylase and polyamine transport. Int J Cancer. 2013 Sep 15;133(6):1323-33. DMR35U4 RU https://pubmed.ncbi.nlm.nih.gov/23457004 DM8B2WQ DI DM8B2WQ DM8B2WQ DN AN-2718 DM8B2WQ MI TT37GL6 DM8B2WQ MN Staphylococcus Leucyl-tRNA synthetase (Stap-coc leuS) DM8B2WQ MT DTT DM8B2WQ MA Inhibitor DM8B2WQ RN Metalloid compounds as drugs. Res Pharm Sci. 2013 Jul-Sep; 8(3): 145-158. DM8B2WQ RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3764666/ DM67OU4 DI DM67OU4 DM67OU4 DN ANAVEX 2-73 DM67OU4 MI TTZ9SOR DM67OU4 MN Muscarinic acetylcholine receptor M1 (CHRM1) DM67OU4 MT DTT DM67OU4 MA Agonist DM67OU4 RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DM67OU4 RU http://phrma-docs.phrma.org/files/dmfile/MID_Neurological-Disorders-Drug-List_2018.pdf DM67OU4 DI DM67OU4 DM67OU4 DN ANAVEX 2-73 DM67OU4 MI TT5TPI6 DM67OU4 MN Opioid receptor sigma 1 (OPRS1) DM67OU4 MT DTT DM67OU4 MA Agonist DM67OU4 RN 2011 Pipeline of Anavex. DM67OU4 RU http://anavex.com/pipeline.html DM39QWN DI DM39QWN DM39QWN DN ANS-6637 DM39QWN MI TTFLN4T DM39QWN MN Mitochondrial aldehyde dehydrogenase (ALDH2) DM39QWN MT DTT DM39QWN MA Inhibitor DM39QWN RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DM39QWN RU http://phrma-docs.phrma.org/files/dmfile/MID_Mental-Illness-2017-Drug-List_Final.pdf DM3OFZC DI DM3OFZC DM3OFZC DN Anti-BCMA CAR T cells DM3OFZC MI TTZ3P4W DM3OFZC MN B-cell maturation protein (TNFRSF17) DM3OFZC MT DTT DM3OFZC MA CAR-T-Cell-Therapy DM3OFZC RN ClinicalTrials.gov (NCT03559764) Study of BCMA CAR-T in Multiple Myeloma DM3OFZC RU https://clinicaltrials.gov/ct2/show/NCT03559764 DMNFO2B DI DMNFO2B DMNFO2B DN Anti-BCMA CAR T cells DMNFO2B MI TTZ3P4W DMNFO2B MN B-cell maturation protein (TNFRSF17) DMNFO2B MT DTT DMNFO2B MA CAR-T-Cell-Therapy DMNFO2B RN ClinicalTrials.gov (NCT02215967) Study of T Cells Targeting B-Cell Maturation Antigen for Previously Treated Multiple Myeloma DMNFO2B RU https://clinicaltrials.gov/ct2/show/NCT02215967 DMUKNDO DI DMUKNDO DMUKNDO DN Anti-BCMA CART Cells DMUKNDO MI TTZ3P4W DMUKNDO MN B-cell maturation protein (TNFRSF17) DMUKNDO MT DTT DMUKNDO MA CAR-T-Cell-Therapy DMUKNDO RN ClinicalTrials.gov (NCT03767725) Anti-BCMA or/and Anti-CD19 CART Cells Treatment of Relapsed Multiple Myeloma DMUKNDO RU https://clinicaltrials.gov/ct2/show/NCT03767725 DM2TFUD DI DM2TFUD DM2TFUD DN Anti-BCMA CAR-T cells DM2TFUD MI TTZ3P4W DM2TFUD MN B-cell maturation protein (TNFRSF17) DM2TFUD MT DTT DM2TFUD MA CAR-T-Cell-Therapy DM2TFUD RN ClinicalTrials.gov (NCT03093168) BCMA Chimeric Antigen Receptor Expressing T Cells in Multiple Myeloma DM2TFUD RU https://clinicaltrials.gov/ct2/show/NCT03093168 DMK25QD DI DMK25QD DMK25QD DN Anti-BCMA CAR-T cells DMK25QD MI TTZ3P4W DMK25QD MN B-cell maturation protein (TNFRSF17) DMK25QD MT DTT DMK25QD MA CAR-T-Cell-Therapy DMK25QD RN ClinicalTrials.gov (NCT03121625) CAR-T Therapy in Relapsed or Refractory Haematopoietic and Lymphoid Malignancies DMK25QD RU https://clinicaltrials.gov/ct2/show/NCT03121625 DMYIZFW DI DMYIZFW DMYIZFW DN Anti-CD123 CAR-T cells DMYIZFW MI TTENHJ0 DMYIZFW MN Interleukin 3 receptor alpha (IL3RA) DMYIZFW MT DTT DMYIZFW MA CAR-T-Cell-Therapy DMYIZFW RN ClinicalTrials.gov (NCT03121625) CAR-T Therapy in Relapsed or Refractory Haematopoietic and Lymphoid Malignancies DMYIZFW RU https://clinicaltrials.gov/ct2/show/NCT03121625 DM82OS7 DI DM82OS7 DM82OS7 DN Anti-CD123 CAR-T treatment DM82OS7 MI TTENHJ0 DM82OS7 MN Interleukin 3 receptor alpha (IL3RA) DM82OS7 MT DTT DM82OS7 MA CAR-T-Cell-Therapy DM82OS7 RN ClinicalTrials.gov (NCT03672851) Study Evaluating Safety and Efficacy of CAR-T Cells Targeting CD123 in Patients With Acute Leukemia DM82OS7 RU https://clinicaltrials.gov/ct2/show/NCT03672851 DMGUM90 DI DMGUM90 DMGUM90 DN Anti-CD133-CAR vector-transduced T cells DMGUM90 MI TTXMZ81 DMGUM90 MN Prominin-1 (PROM1) DMGUM90 MT DTT DMGUM90 MA CAR-T-Cell-Therapy DMGUM90 RN ClinicalTrials.gov (NCT02541370) Treatment of Relapsed and/or Chemotherapy Refractory Advanced Malignancies by CART133 DMGUM90 RU https://clinicaltrials.gov/ct2/show/NCT02541370 DMCABUR DI DMCABUR DMCABUR DN Anti-CD19 anti-CD20 Bispecific CAR-T DMCABUR MI TTW640A DMCABUR MN B-lymphocyte surface antigen B4 (CD19) DMCABUR MT DTT DMCABUR MA CAR-T-Cell-Therapy(Dual specific) DMCABUR RN ClinicalTrials.gov (NCT03271515) Immunotherapy With Bispecific CAR-T Cells for B-Cell Lymphoma, ALL and CLL DMCABUR RU https://clinicaltrials.gov/ct2/show/NCT03271515 DMCABUR DI DMCABUR DMCABUR DN Anti-CD19 anti-CD20 Bispecific CAR-T DMCABUR MI TTUE541 DMCABUR MN Leukocyte surface antigen Leu-16 (CD20) DMCABUR MT DTT DMCABUR MA CAR-T-Cell-Therapy(Dual specific) DMCABUR RN ClinicalTrials.gov (NCT03271515) Immunotherapy With Bispecific CAR-T Cells for B-Cell Lymphoma, ALL and CLL DMCABUR RU https://clinicaltrials.gov/ct2/show/NCT03271515 DMH789J DI DMH789J DMH789J DN AntiCD19 CART DMH789J MI TTW640A DMH789J MN B-lymphocyte surface antigen B4 (CD19) DMH789J MT DTT DMH789J MA CAR-T-Cell-Therapy DMH789J RN ClinicalTrials.gov (NCT03434769) AntiCD19 Chimeric Antigen Receptor T Cells for Relapsed or Refractory Non Hodgkin Lymphoma DMH789J RU https://clinicaltrials.gov/ct2/show/NCT03434769 DM9W1BS DI DM9W1BS DM9W1BS DN Anti-CD19 CAR-T DM9W1BS MI TTW640A DM9W1BS MN B-lymphocyte surface antigen B4 (CD19) DM9W1BS MT DTT DM9W1BS MA CAR-T-Cell-Therapy DM9W1BS RN ClinicalTrials.gov (NCT03110640) Anti-CD19 CAR T Infusion Combined With Allogeneic Stem Cell Transplantation for B-cell Leukemia/Lymphoma DM9W1BS RU https://clinicaltrials.gov/ct2/show/NCT03110640 DMW549Y DI DMW549Y DMW549Y DN Anti-CD19 CART Cells DMW549Y MI TTW640A DMW549Y MN B-lymphocyte surface antigen B4 (CD19) DMW549Y MT DTT DMW549Y MA CAR-T-Cell-Therapy DMW549Y RN ClinicalTrials.gov (NCT03767725) Anti-BCMA or/and Anti-CD19 CART Cells Treatment of Relapsed Multiple Myeloma DMW549Y RU https://clinicaltrials.gov/ct2/show/NCT03767725 DMUQ3C1 DI DMUQ3C1 DMUQ3C1 DN Anti-CD19 CAR-T cells DMUQ3C1 MI TTW640A DMUQ3C1 MN B-lymphocyte surface antigen B4 (CD19) DMUQ3C1 MT DTT DMUQ3C1 MA CAR-T-Cell-Therapy DMUQ3C1 RN ClinicalTrials.gov (NCT03121625) CAR-T Therapy in Relapsed or Refractory Haematopoietic and Lymphoid Malignancies DMUQ3C1 RU https://clinicaltrials.gov/ct2/show/NCT03121625 DMUVYC5 DI DMUVYC5 DMUVYC5 DN Anti-CD19 EBV CTL therapy DMUVYC5 MI TTW640A DMUVYC5 MN B-lymphocyte surface antigen B4 (CD19) DMUVYC5 MT DTT DMUVYC5 RN Cytotoxic T cells transduced with chimeric anti-CD19 receptors prevent engraftment of primary lymphoblastic leukemia in vivo. Leukemia. 2010 May;24(5):1080-4. DMUVYC5 RU https://pubmed.ncbi.nlm.nih.gov/20220773 DMF93T2 DI DMF93T2 DMF93T2 DN Anti-CD19/BCMA CAR-T cells DMF93T2 MI TTZ3P4W DMF93T2 MN B-cell maturation protein (TNFRSF17) DMF93T2 MT DTT DMF93T2 MA CAR-T-Cell-Therapy(Dual specific) DMF93T2 RN ClinicalTrials.gov (NCT03706547) Anti-CD19/BCMA Bispecific CAR-T Cell Therapy for R/R MM DMF93T2 RU https://clinicaltrials.gov/ct2/show/NCT03706547 DMF93T2 DI DMF93T2 DMF93T2 DN Anti-CD19/BCMA CAR-T cells DMF93T2 MI TTW640A DMF93T2 MN B-lymphocyte surface antigen B4 (CD19) DMF93T2 MT DTT DMF93T2 MA CAR-T-Cell-Therapy(Dual specific) DMF93T2 RN ClinicalTrials.gov (NCT03706547) Anti-CD19/BCMA Bispecific CAR-T Cell Therapy for R/R MM DMF93T2 RU https://clinicaltrials.gov/ct2/show/NCT03706547 DMWKYSM DI DMWKYSM DMWKYSM DN Anti-CD19-CAR DMWKYSM MI TTW640A DMWKYSM MN B-lymphocyte surface antigen B4 (CD19) DMWKYSM MT DTT DMWKYSM MA CAR-T-Cell-Therapy DMWKYSM RN ClinicalTrials.gov (NCT01593696) Anti-CD19 White Blood Cells for Children and Young Adults With B Cell Leukemia or Lymphoma DMWKYSM RU https://clinicaltrials.gov/ct2/show/NCT01593696 DMMRANJ DI DMMRANJ DMMRANJ DN Anti-CD19-CAR T DMMRANJ MI TTW640A DMMRANJ MN B-lymphocyte surface antigen B4 (CD19) DMMRANJ MT DTT DMMRANJ MA CAR-T-Cell-Therapy DMMRANJ RN ClinicalTrials.gov (NCT02546739) Immunotherapy With CD19 CAR T-cells for B-Cell Lymphoma, ALL and CLL DMMRANJ RU https://clinicaltrials.gov/ct2/show/NCT02546739 DMYQFCN DI DMYQFCN DMYQFCN DN Anti-CD19-CAR T cells DMYQFCN MI TTW640A DMYQFCN MN B-lymphocyte surface antigen B4 (CD19) DMYQFCN MT DTT DMYQFCN MA CAR-T-Cell-Therapy DMYQFCN RN ClinicalTrials.gov (NCT02659943) T Cells Expressing a Fully-human AntiCD19 Chimeric Antigen Receptor for Treating B-cell Malignancies DMYQFCN RU https://clinicaltrials.gov/ct2/show/NCT02659943 DMUFRDK DI DMUFRDK DMUFRDK DN Anti-CD22 DMUFRDK MI TTM6QSK DMUFRDK MN B-cell receptor CD22 (CD22) DMUFRDK MT DTT DMUFRDK RN 2011 Pipeline of Seattle Genetics. DMUFRDK RU http://www.seagen.com/product_pipeline.php DMKL92E DI DMKL92E DMKL92E DN Anti-CD22 CAR-T cells DMKL92E MI TTM6QSK DMKL92E MN B-cell receptor CD22 (CD22) DMKL92E MT DTT DMKL92E MA CAR-T-Cell-Therapy DMKL92E RN ClinicalTrials.gov (NCT03121625) CAR-T Therapy in Relapsed or Refractory Haematopoietic and Lymphoid Malignancies DMKL92E RU https://clinicaltrials.gov/ct2/show/NCT03121625 DMTK78L DI DMTK78L DMTK78L DN Anti-CD30 CAR-T cells DMTK78L MI TT2GM5R DMTK78L MN Lymphocyte activation antigen CD30 (TNFRSF8) DMTK78L MT DTT DMTK78L MA CAR-T-Cell-Therapy DMTK78L RN ClinicalTrials.gov (NCT03121625) CAR-T Therapy in Relapsed or Refractory Haematopoietic and Lymphoid Malignancies DMTK78L RU https://clinicaltrials.gov/ct2/show/NCT03121625 DM2IEB7 DI DM2IEB7 DM2IEB7 DN Anti-CD30-CAR T cells DM2IEB7 MI TT2GM5R DM2IEB7 MN Lymphocyte activation antigen CD30 (TNFRSF8) DM2IEB7 MT DTT DM2IEB7 MA CAR-T-Cell-Therapy DM2IEB7 RN ClinicalTrials.gov (NCT03049449) T Cells Expressing a Fully-Human Anti-CD30 Chimeric Antigen Receptor for Treating CD30-Expressing Lymphomas DM2IEB7 RU https://clinicaltrials.gov/ct2/show/NCT03049449 DMVSPZM DI DMVSPZM DMVSPZM DN Anti-CD38 CAR-T cells DMVSPZM MI TTPURFN DMVSPZM MN Cyclic ADP-ribose hydrolase 1 (CD38) DMVSPZM MT DTT DMVSPZM MA CAR-T-Cell-Therapy DMVSPZM RN ClinicalTrials.gov (NCT03464916) Study to Evaluate the Safety and Efficacy of Anti-CD38 CAR-T in Relapsed or Refractory Multiple Myeloma Patients DMVSPZM RU https://clinicaltrials.gov/ct2/show/NCT03464916 DMZ2D0G DI DMZ2D0G DMZ2D0G DN Anti-CD45 mabs DMZ2D0G MI TTUS45N DMZ2D0G MN Leukocyte common antigen (PTPRC) DMZ2D0G MT DTT DMZ2D0G RN CD45 monoclonal antibody-mediated cytolysis of human NK and T lymphoma cells. Haematologica. 2006 Jul;91(7):886-94. DMZ2D0G RU https://pubmed.ncbi.nlm.nih.gov/16818275 DMMFL2P DI DMMFL2P DMMFL2P DN Anti-CD7 CAR-T cells DMMFL2P MI TTP6B8O DMMFL2P MN T-cell antigen CD7 (CD7) DMMFL2P MT DTT DMMFL2P MA CAR-T-Cell-Therapy DMMFL2P RN ClinicalTrials.gov (NCT03121625) CAR-T Therapy in Relapsed or Refractory Haematopoietic and Lymphoid Malignancies DMMFL2P RU https://clinicaltrials.gov/ct2/show/NCT03121625 DMDZR0V DI DMDZR0V DMDZR0V DN Anti-CEA CAR-T cells DMDZR0V MI TTY6DTE DMDZR0V MN Carcinoembryonic antigen CEA (CD66e) DMDZR0V MT DTT DMDZR0V MA CAR-T-Cell-Therapy DMDZR0V RN ClinicalTrials.gov (NCT03682744) CAR-T Intraperitoneal Infusions for CEA-Expressing Adenocarcinoma Peritoneal Metastases or Malignant Ascites (IPC) DMDZR0V RU https://clinicaltrials.gov/ct2/show/NCT03682744 DMA7L3O DI DMA7L3O DMA7L3O DN Anti-CEA CAR-T cells DMA7L3O MI TTY6DTE DMA7L3O MN Carcinoembryonic antigen CEA (CD66e) DMA7L3O MT DTT DMA7L3O MA CAR-T-Cell-Therapy DMA7L3O RN ClinicalTrials.gov (NCT02416466) CAR-T Hepatic Artery Infusions and Sir-Spheres for Liver Metastases DMA7L3O RU https://clinicaltrials.gov/ct2/show/NCT02416466 DMJA3H1 DI DMJA3H1 DMJA3H1 DN Anti-CEA-CAR T DMJA3H1 MI TTY6DTE DMJA3H1 MN Carcinoembryonic antigen CEA (CD66e) DMJA3H1 MT DTT DMJA3H1 MA CAR-T-Cell-Therapy DMJA3H1 RN ClinicalTrials.gov (NCT02349724) A Clinical Research of CAR T Cells Targeting CEA Positive Cancer DMJA3H1 RU https://clinicaltrials.gov/ct2/show/NCT02349724 DM0ZDJ5 DI DM0ZDJ5 DM0ZDJ5 DN Anti-EGFL7 DM0ZDJ5 MI TT7WD0H DM0ZDJ5 MN Epidermal growth factor-like protein 7 (EGFL7) DM0ZDJ5 MT DTT DM0ZDJ5 RN Clinical pipeline report, company report or official report of Genentech (2009). DM0ZDJ5 RU http://www.gene.com/gene/pipeline/status/ DMIVUX1 DI DMIVUX1 DMIVUX1 DN Anti-EGFR CAR T DMIVUX1 MI TTGKNB4 DMIVUX1 MN Epidermal growth factor receptor (EGFR) DMIVUX1 MT DTT DMIVUX1 MA CAR-T-Cell-Therapy DMIVUX1 RN ClinicalTrials.gov (NCT02331693) CAR T Cells in Treating Patients With Malignant Gliomas Overexpressing EGFR DMIVUX1 RU https://clinicaltrials.gov/ct2/show/NCT02331693 DM73920 DI DM73920 DM73920 DN Anti-EGFRvIII CAR T cells DM73920 MI TTZ6B2I DM73920 MN Epidermal growth factor receptor variant III (EGFR vIII) DM73920 MT DTT DM73920 MA CAR-T-Cell-Therapy DM73920 RN ClinicalTrials.gov (NCT02844062) Pilot Study of Autologous Anti-EGFRvIII CAR T Cells in Recurrent Glioblastoma Multiforme DM73920 RU https://clinicaltrials.gov/ct2/show/NCT02844062 DM6QENU DI DM6QENU DM6QENU DN Anti-FGFR3 DM6QENU MI TTST7KB DM6QENU MN Fibroblast growth factor receptor 3 (FGFR3) DM6QENU MT DTT DM6QENU RN Clinical pipeline report, company report or official report of Genentech (2011). DM6QENU RU http://www.gene.com/gene/index.jsp DMBVUFL DI DMBVUFL DMBVUFL DN Anti-GD2 T-cells (1RG-CART) DMBVUFL MI TT80ARU DMBVUFL MN Ganglioside GD2 (GD2) DMBVUFL MT DTT DMBVUFL MA CAR-T-Cell-Therapy DMBVUFL RN ClinicalTrials.gov (NCT02761915) A Cancer Research UK Trial of Anti-GD2 T-cells (1RG-CART) DMBVUFL RU https://clinicaltrials.gov/ct2/show/NCT02761915 DMCNFZG DI DMCNFZG DMCNFZG DN Anti-GD2-CAR engineered T cells DMCNFZG MI TT80ARU DMCNFZG MN Ganglioside GD2 (GD2) DMCNFZG MT DTT DMCNFZG MA CAR-T-Cell-Therapy DMCNFZG RN ClinicalTrials.gov (NCT02107963) A Phase I Trial of T Cells Expressing an Anti-GD2 Chimeric Antigen Receptor in Children and Young Adults With GD2+ Solid Tumors DMCNFZG RU https://clinicaltrials.gov/ct2/show/NCT02107963 DMUMWFK DI DMUMWFK DMUMWFK DN Anti-GPC3 CAR T DMUMWFK MI TTJTSX4 DMUMWFK MN Glypican-3 (GPC3) DMUMWFK MT DTT DMUMWFK MA CAR-T-Cell-Therapy DMUMWFK RN ClinicalTrials.gov (NCT02395250) Anti-GPC3 CAR T for Treating Patients With Advanced HCC DMUMWFK RU https://clinicaltrials.gov/ct2/show/NCT02395250 DMK4GIS DI DMK4GIS DMK4GIS DN Anti-hCD70 CAR transduced PBL DMK4GIS MI TTNCIE0 DMK4GIS MN CD70 antigen (CD27-L) DMK4GIS MT DTT DMK4GIS MA CAR-T-Cell-Therapy DMK4GIS RN ClinicalTrials.gov (NCT02830724) Administering Peripheral Blood Lymphocytes Transduced With a CD70-Binding Chimeric Antigen Receptor to People With CD70 Expressing Cancers DMK4GIS RU https://clinicaltrials.gov/ct2/show/NCT02830724 DMDMNJ6 DI DMDMNJ6 DMDMNJ6 DN Anti-HER3/EGFR DAF DMDMNJ6 MI TTGKNB4 DMDMNJ6 MN Epidermal growth factor receptor (EGFR) DMDMNJ6 MT DTT DMDMNJ6 MA Modulator DMDMNJ6 RN Company report (Biooncology) DMDMNJ6 RU http://www.biooncology.com/pipeline-molecules/anti-her3 DMDMNJ6 DI DMDMNJ6 DMDMNJ6 DN Anti-HER3/EGFR DAF DMDMNJ6 MI TTDC8N2 DMDMNJ6 MN Erbb3 tyrosine kinase receptor (Erbb-3) DMDMNJ6 MT DTT DMDMNJ6 MA Modulator DMDMNJ6 RN Company report (Biooncology) DMDMNJ6 RU http://www.biooncology.com/pipeline-molecules/anti-her3 DMY2MO4 DI DMY2MO4 DMY2MO4 DN Anti-meso-CAR T cells DMY2MO4 MI TT4RXME DMY2MO4 MN Mesothelin (MSLN) DMY2MO4 MT DTT DMY2MO4 MA CAR-T-Cell-Therapy DMY2MO4 RN ClinicalTrials.gov (NCT02580747) Treatment of Relapsed and/or Chemotherapy Refractory Advanced Malignancies by CART-meso DMY2MO4 RU https://clinicaltrials.gov/ct2/show/NCT02580747 DM5UQA9 DI DM5UQA9 DM5UQA9 DN Anti-meso-CAR vector transduced T cells DM5UQA9 MI TT4RXME DM5UQA9 MN Mesothelin (MSLN) DM5UQA9 MT DTT DM5UQA9 MA CAR-T-Cell-Therapy DM5UQA9 RN ClinicalTrials.gov (NCT02580747) Treatment of Relapsed and/or Chemotherapy Refractory Advanced Malignancies by CART-meso DM5UQA9 RU https://clinicaltrials.gov/ct2/show/NCT02580747 DM5BIM1 DI DM5BIM1 DM5BIM1 DN Anti-mesothelin CAR T Cells DM5BIM1 MI TT4RXME DM5BIM1 MN Mesothelin (MSLN) DM5BIM1 MT DTT DM5BIM1 MA CAR-T-Cell-Therapy DM5BIM1 RN ClinicalTrials.gov (NCT02930993) Anti-mesothelin CAR T Cells for Patients With Recurrent or Metastatic Malignant Tumors DM5BIM1 RU https://clinicaltrials.gov/ct2/show/NCT02930993 DMUKFCG DI DMUKFCG DMUKFCG DN Anti-Mesothelin CAR-T cells DMUKFCG MI TT4RXME DMUKFCG MN Mesothelin (MSLN) DMUKFCG MT DTT DMUKFCG MA CAR-T-Cell-Therapy DMUKFCG RN ClinicalTrials.gov (NCT03545815) Study of CRISPR-Cas9 Mediated PD-1 and TCR Gene-knocked Out Mesothelin-directed CAR-T Cells in Patients With Mesothelin Positive Multiple Solid Tumors. DMUKFCG RU https://clinicaltrials.gov/ct2/show/NCT03545815 DMQ5ZND DI DMQ5ZND DMQ5ZND DN Anti-MUC1 mab DMQ5ZND MI TTBHFYQ DMQ5ZND MN Mucin-1 (MUC1) DMQ5ZND MT DTT DMQ5ZND MA Modulator DMQ5ZND RN Characterization of an anti-MUC1 monoclonal antibody with potential as a cancer vaccine. Hybrid Hybridomics. 2001;20(5-6):313-24. DMQ5ZND RU https://pubmed.ncbi.nlm.nih.gov/11839249 DMRWI7E DI DMRWI7E DMRWI7E DN Anti-N3pG-Abeta antibody DMRWI7E MI TTE4KHA DMRWI7E MN Amyloid beta A4 protein (APP) DMRWI7E MT DTT DMRWI7E RN LY3002813 Alzheimer's Disease (Phase 1). Eli Lilly & Co. DMRWI7E RU http://www.alzforum.org/therapeutics/ly3002813 DMFZ52G DI DMFZ52G DMFZ52G DN Anti-OX40 mab DMFZ52G MI TTL31H0 DMFZ52G MN OX40L receptor (CD134) DMFZ52G MT DTT DMFZ52G MA Modulator DMFZ52G RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1873). DMFZ52G RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1873 DM0UL47 DI DM0UL47 DM0UL47 DN Anti-PD-L1 DM0UL47 MI TT8ZLTI DM0UL47 MN Programmed cell death 1 ligand 1 (PD-L1) DM0UL47 MT DTT DM0UL47 RN Safety and activity of anti-PD-L1 antibody in patients with advanced cancer. N Engl J Med. 2012 Jun 28;366(26):2455-65. DM0UL47 RU https://pubmed.ncbi.nlm.nih.gov/22658128 DMWIJL1 DI DMWIJL1 DMWIJL1 DN Anti-PD-L1 CSR T cells DMWIJL1 MI TT8ZLTI DMWIJL1 MN Programmed cell death 1 ligand 1 (PD-L1) DMWIJL1 MT DTT DMWIJL1 MA CAR-T-Cell-Therapy DMWIJL1 RN ClinicalTrials.gov (NCT02937844) Pilot Study of Autologous Chimeric Switch Receptor Modified T Cells in Recurrent Glioblastoma Multiforme DMWIJL1 RU https://clinicaltrials.gov/ct2/show/NCT02937844 DMAESIY DI DMAESIY DMAESIY DN ANX005 DMAESIY MI TT7LRQH DMAESIY MN Complement C1s component (C1S) DMAESIY MT DTT DMAESIY MA Inhibitor DMAESIY RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMAESIY RU http://phrma-docs.phrma.org/files/dmfile/MID_Neurological-Disorders-Drug-List_2018.pdf DM7XES6 DI DM7XES6 DM7XES6 DN ANX-042 DM7XES6 MI TTWVLS6 DM7XES6 MN Natriuretic peptide receptor (NPR3) DM7XES6 MT DTT DM7XES6 MA Modulator DM7XES6 RN Renin-Angiotensin Blockade Combined With Natriuretic Peptide System Augmentation: Novel Therapeutic Concepts to Combat Heart Failure. Circ Heart Fail. 2013 May; 6(3): 594-605. DM7XES6 RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3981104/ DMGDARN DI DMGDARN DMGDARN DN AP32788 DMGDARN MI TTGKNB4 DMGDARN MN Epidermal growth factor receptor (EGFR) DMGDARN MT DTT DMGDARN MA Inhibitor DMGDARN RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMGDARN RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DM36FOG DI DM36FOG DM36FOG DN APD-597 DM36FOG MI TT7QNVC DM36FOG MN Glucose-dependent insulinotropic receptor (GPR119) DM36FOG MT DTT DM36FOG MA Agonist DM36FOG RN Discovery of a second generation agonist of the orphan G-protein coupled receptor GPR119 with an improved profile. Bioorg Med Chem Lett. 2012 Feb 15;22(4):1750-5. DM36FOG RU https://pubmed.ncbi.nlm.nih.gov/22264481 DMRGF9Q DI DMRGF9Q DMRGF9Q DN APD-916 DMRGF9Q MI TT9JNIC DMRGF9Q MN Histamine H3 receptor (H3R) DMRGF9Q MT DTT DMRGF9Q MA Antagonist DMRGF9Q RN Identification of biaryl sulfone derivatives as antagonists of the histamine H receptor: discovery of (R)-1-(2-(4'-(3-methoxypropylsulfonyl)biphenyl-4-yl)ethyl)-2-methylpyrrolidine (APD916). Bioorg Med Chem Lett. 2012 Jan 1;22(1):71-5. DMRGF9Q RU https://pubmed.ncbi.nlm.nih.gov/22172695 DMLEKUY DI DMLEKUY DMLEKUY DN APG-1387 DMLEKUY MI TTS74QB DMLEKUY MN Inhibitor of apoptosis protein (hIAP) DMLEKUY MT DTT DMLEKUY MA Inhibitor DMLEKUY RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMLEKUY RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DMLEKUY DI DMLEKUY DMLEKUY DN APG-1387 DMLEKUY MI TTR7B60 DMLEKUY MN X-linked inhibitor of apoptosis protein (XIAP) DMLEKUY MT DTT DMLEKUY MA Antagonist DMLEKUY RN XIAP Limits Autophagic Degradation of Sox2 and Is A Therapeutic Target in Nasopharyngeal Carcinoma Stem Cells.Theranostics. 2018 Feb 5;8(6):1494-1510. DMLEKUY RU https://pubmed.ncbi.nlm.nih.gov/29556337 DM6P93J DI DM6P93J DM6P93J DN API-023 DM6P93J MI TTF1QVM DM6P93J MN Gastric H(+)/K(+) ATPase alpha (ATP4A) DM6P93J MT DTT DM6P93J MA Inhibitor DM6P93J RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 849). DM6P93J RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=849 DM4WAC2 DI DM4WAC2 DM4WAC2 DN APL-501 DM4WAC2 MI TTNBFWK DM4WAC2 MN Programmed cell death protein 1 (PD-1) DM4WAC2 MT DTT DM4WAC2 MA Inhibitor DM4WAC2 RN Clinical pipeline report, company report or official report of Apollomics. DM4WAC2 RU https://www.apollomicsinc.com/zh-hans/pipeline-drugs/apl-501/ DMPJBCR DI DMPJBCR DMPJBCR DN APO-010 DMPJBCR MI TTF0RCZ DMPJBCR MN Apoptosis mediating surface antigen FAS (FAS) DMPJBCR MT DTT DMPJBCR MA Binder DMPJBCR RN APO010, a synthetic hexameric CD95 ligand, induces human glioma cell death in vitro and in vivo. Neuro Oncol. 2011 Feb;13(2):155-64. DMPJBCR RU https://pubmed.ncbi.nlm.nih.gov/21183510 DMU8QD2 DI DMU8QD2 DMU8QD2 DN Apramycin DMU8QD2 MI TT38DW5 DMU8QD2 MN Bacterial 16S ribosomal RNA (Bact 16S rRNA) DMU8QD2 MT DTT DMU8QD2 MA Inhibitor DMU8QD2 RN RNA as a target for small molecules. Curr Opin Chem Biol. 2000 Dec;4(6):678-86. DMU8QD2 RU https://pubmed.ncbi.nlm.nih.gov/11102874 DMXIKYR DI DMXIKYR DMXIKYR DN APTO-253 DMXIKYR MI TTTI53X DMXIKYR MN Kruppel like factor 4 (KLF4) DMXIKYR MT DTT DMXIKYR MA Inhibitor DMXIKYR RN Phase 1 study of APTO-253 HCl, an inducer of KLF4, in patients with advanced or metastatic solid tumors. Invest New Drugs. 2015 Oct;33(5):1086-92. DMXIKYR RU https://pubmed.ncbi.nlm.nih.gov/26268924 DMXDMH5 DI DMXDMH5 DMXDMH5 DN APVO414 DMXDMH5 MI TT9G4N0 DMXDMH5 MN Glutamate carboxypeptidase II (GCPII) DMXDMH5 MT DTT DMXDMH5 MA Inhibitor DMXDMH5 RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMXDMH5 RU http://phrma-docs.phrma.org/files/dmfile/MID_Immuno-Oncology-2017_Drug-List1.pdf DMUAMZY DI DMUAMZY DMUAMZY DN APVO436 DMUAMZY MI TTENHJ0 DMUAMZY MN Interleukin 3 receptor alpha (IL3RA) DMUAMZY MT DTT DMUAMZY MA Inhibitor DMUAMZY RN Clinical pipeline report, company report or official report of Aptevo. DMUAMZY RU https://aptevotherapeutics.com/apvo436-anti-cd123-x-anti-cd3/ DMUAMZY DI DMUAMZY DMUAMZY DN APVO436 DMUAMZY MI TTUN7MC DMUAMZY MN T-cell surface glycoprotein CD3 (CD3) DMUAMZY MT DTT DMUAMZY MA Inhibitor DMUAMZY RN Clinical pipeline report, company report or official report of Aptevo. DMUAMZY RU https://aptevotherapeutics.com/apvo436-anti-cd123-x-anti-cd3/ DMXIMQT DI DMXIMQT DMXIMQT DN APX-3330 DMXIMQT MI TTHGL48 DMXIMQT MN AP endonuclease 1 (APEX1) DMXIMQT MT DTT DMXIMQT MA Inhibitor DMXIMQT RN Inhibition of APE1/Ref-1 redox activity with APX3330 blocks retinal angiogenesis in vitro and in vivo. Vision Res. 2011 Jan;51(1):93-100. DMXIMQT RU https://pubmed.ncbi.nlm.nih.gov/20937296 DM4RK6P DI DM4RK6P DM4RK6P DN AR-12 DM4RK6P MI TT9QBI6 DM4RK6P MN Phosphoinositide dependent protein kinase-1 (PDPK1) DM4RK6P MT DTT DM4RK6P MA Modulator DM4RK6P RN Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41. DM4RK6P RU https://www.ncbi.nlm.nih.gov/pubmed/15950434 DMY0DPM DI DMY0DPM DMY0DPM DN ARC-1905 DMY0DPM MI TTKANGO DMY0DPM MN Complement C5 (CO5) DMY0DPM MT DTT DMY0DPM RN ClinicalTrials.gov (NCT00950638) A Study of ARC1905 (Anti-C5 Aptamer) in Subjects With Dry Age-related Macular Degeneration. U.S. National Institutes of Health. DMY0DPM RU https://clinicaltrials.gov/ct2/show/NCT00950638 DMFJZK3 DI DMFJZK3 DMFJZK3 DN Arecoline DMFJZK3 MI TTZ9SOR DMFJZK3 MN Muscarinic acetylcholine receptor M1 (CHRM1) DMFJZK3 MT DTT DMFJZK3 MA Inhibitor DMFJZK3 RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMFJZK3 RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMPLHBI DI DMPLHBI DMPLHBI DN ARI-0001 cells DMPLHBI MI TTW640A DMPLHBI MN B-lymphocyte surface antigen B4 (CD19) DMPLHBI MT DTT DMPLHBI MA CAR-T-Cell-Therapy DMPLHBI RN ClinicalTrials.gov (NCT03144583) Pilot Study on the Infusion of ARI-0001 Cells in Patients With CD19+ Leukemia or Lymphoma Refractory to Therapy DMPLHBI RU https://clinicaltrials.gov/ct2/show/NCT03144583 DMN4D3A DI DMN4D3A DMN4D3A DN ARI-2243 DMN4D3A MI TTDIGC1 DMN4D3A MN Dipeptidyl peptidase 4 (DPP-4) DMN4D3A MT DTT DMN4D3A MA Modulator DMN4D3A RN Incorporating Incretin-Based Therapies Into Clinical Practice: Differences Between Glucagon-Like Peptide 1 Receptor Agonists and Dipeptidyl Peptidase 4 Inhibitors. Mayo Clin Proc. 2010 December; 85(12 Suppl): S27-S37. DMN4D3A RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2996165/ DMY5IM2 DI DMY5IM2 DMY5IM2 DN ARL-67085 DMY5IM2 MI TTZ1DT0 DMY5IM2 MN P2Y purinoceptor 12 (P2RY12) DMY5IM2 MT DTT DMY5IM2 MA Agonist DMY5IM2 RN Pharmacological characterization of the human P2Y11 receptor. Br J Pharmacol. 1999 Nov;128(6):1199-206. DMY5IM2 RU https://pubmed.ncbi.nlm.nih.gov/10578132 DMQUFNY DI DMQUFNY DMQUFNY DN ARM210 DMQUFNY MI TT9YXM1 DMQUFNY MN Ryanodine receptor (RYR) DMQUFNY MT DTT DMQUFNY MA Modulator DMQUFNY RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMQUFNY RU http://phrma-docs.phrma.org/sites/default/files/pdf/medicines-in-development-drug-list-rare-diseases.pdf DM4D85V DI DM4D85V DM4D85V DN ARN-6039 DM4D85V MI TTGV6LY DM4D85V MN Nuclear receptor ROR-gamma (RORG) DM4D85V MT DTT DM4D85V MA Agonist DM4D85V RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DM4D85V RU http://phrma-docs.phrma.org/files/dmfile/MID_Neurological-Disorders-Drug-List_2018.pdf DM5R7VI DI DM5R7VI DM5R7VI DN ARN-6039 DM5R7VI MI TTGV6LY DM5R7VI MN Nuclear receptor ROR-gamma (RORG) DM5R7VI MT DTT DM5R7VI MA Agonist DM5R7VI RN Clinical pipeline report, company report or official report of Arrien Pharmaceuticals. DM5R7VI RU https://www.arrienpharma.com/arn-6039.html DMV5PEK DI DMV5PEK DMV5PEK DN ARO-HIF2 DMV5PEK MI TTWPA54 DMV5PEK MN HIF2-alpha messenger RNA (EPAS1 mRNA) DMV5PEK MT DTT DMV5PEK MA Inhibitor DMV5PEK RN National Cancer Institute Drug Dictionary (drug name ARO-HIF2). DMV5PEK RU https://www.cancer.gov/publications/dictionaries/cancer-drug/def/hif2a-rnai-aro-hif2 DMCRLQZ DI DMCRLQZ DMCRLQZ DN ARQ 621 DMCRLQZ MI TTTRP0H DMCRLQZ MN Kinesin-like protein KIF11 (KIF11) DMCRLQZ MT DTT DMCRLQZ MA Modulator DMCRLQZ RN Kinesins and cancer. Nat Rev Cancer. 2012 Jul 24;12(8):527-39. DMCRLQZ RU https://pubmed.ncbi.nlm.nih.gov/22825217 DMP9ZT1 DI DMP9ZT1 DMP9ZT1 DN ARQ 736 DMP9ZT1 MI TTWCGQT DMP9ZT1 MN Serine/threonine-protein kinase B-raf (BRAF) DMP9ZT1 MT DTT DMP9ZT1 MA Modulator DMP9ZT1 RN National Cancer Institute Drug Dictionary (drug id 688029). DMP9ZT1 RU http://www.cancer.gov/publications/dictionaries/cancer-drug?cdrid=688029 DM7MWX0 DI DM7MWX0 DM7MWX0 DN ARQ 751 DM7MWX0 MI TTWTSCV DM7MWX0 MN RAC-alpha serine/threonine-protein kinase (AKT1) DM7MWX0 MT DTT DM7MWX0 MA Inhibitor DM7MWX0 RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DM7MWX0 RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DM1FTEC DI DM1FTEC DM1FTEC DN ARQ-171 DM1FTEC MI TTVJDNB DM1FTEC MN E2F transcription factor 1 (E2F1) DM1FTEC MT DTT DM1FTEC MA Modulator DM1FTEC RN Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800025396) DM1FTEC RU http://adisinsight.springer.com/drugs/800025396 DMBQWVR DI DMBQWVR DMBQWVR DN ARQ-751 DMBQWVR MI TTQ7UAP DMBQWVR MN RAC serine/threonine-protein kinase (AKT) DMBQWVR MT DTT DMBQWVR MA Inhibitor DMBQWVR RN Targeting AKT1-E17K and the PI3K/AKT Pathway with an Allosteric AKT Inhibitor, ARQ 092. PLoS One. 2015 Oct 15;10(10):e0140479. DMBQWVR RU https://pubmed.ncbi.nlm.nih.gov/26469692 DMMPTCK DI DMMPTCK DMMPTCK DN ARRY-300 DMMPTCK MI TTROQ37 DMMPTCK MN MAPK/ERK kinase kinase (MAP3K) DMMPTCK MT DTT DMMPTCK MA Modulator DMMPTCK RN MEK and the inhibitors: from bench to bedside. J Hematol Oncol. 2013 Apr 12;6:27. DMMPTCK RU https://pubmed.ncbi.nlm.nih.gov/23587417 DMCNV0M DI DMCNV0M DMCNV0M DN ARRY-380 DMCNV0M MI TT6EO5L DMCNV0M MN Erbb2 tyrosine kinase receptor (HER2) DMCNV0M MT DTT DMCNV0M MA Modulator DMCNV0M RN ARRY-380, a Potent, Small Molecule Inhibitor of ErbB2, Increases Survival in Intracranial ErbB2+ Xenograft Models in Mice DMCNV0M RU http://arraybiopharma.com/publications/arry-380-potent-small-molecule-inhibitor-erbb2-increases-survival-intracranial-erbb2-xenograft-models-mice/ DM4CZ2Y DI DM4CZ2Y DM4CZ2Y DN ARX-424 DM4CZ2Y MI TT4TZ8J DM4CZ2Y MN Interferon-beta (IFNB1) DM4CZ2Y MT DTT DM4CZ2Y MA Modulator DM4CZ2Y RN PEGylated interferon beta-1a in the treatment of multiple sclerosis - an update. Biologics. 2013; 7: 131-138. DM4CZ2Y RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3686537/ DMM9ORD DI DMM9ORD DMM9ORD DN ASG-15ME DMM9ORD MI TTTVEKI DMM9ORD MN SLIT and NTRK-like family member 6 (SLITRK6) DMM9ORD MT DTT DMM9ORD RN Clinical pipeline report, company report or official report of Seattle Genetics. DMM9ORD RU http://www.seattlegenetics.com/asg15me DM0Z3JS DI DM0Z3JS DM0Z3JS DN ASG-22ME DM0Z3JS MI TTPO9EG DM0Z3JS MN Nectin cell adhesion molecule 4 (NECTIN4) DM0Z3JS MT DTT DM0Z3JS RN 2011 Pipeline of Seattle Genetics. DM0Z3JS RU http://www.seagen.com/product_pipeline.php DMD0BMN DI DMD0BMN DMD0BMN DN ASG-5ME DMD0BMN MI TT0NYDG DMD0BMN MN Choline transporter-like protein 4 (SLC44A4) DMD0BMN MT DTT DMD0BMN RN 2011 Pipeline of Seattle Genetics. DMD0BMN RU http://www.seagen.com/product_pipeline.php DMJCX6D DI DMJCX6D DMJCX6D DN ASN003 DMJCX6D MI TTWCGQT DMJCX6D MN Serine/threonine-protein kinase B-raf (BRAF) DMJCX6D MT DTT DMJCX6D MA Inhibitor DMJCX6D RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMJCX6D RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DMYHEUA DI DMYHEUA DMYHEUA DN ASN007 DMYHEUA MI TT1MG9E DMYHEUA MN Extracellular signal-regulated kinase 1 (ERK1) DMYHEUA MT DTT DMYHEUA MA Inhibitor DMYHEUA RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMYHEUA RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DM8DBT6 DI DM8DBT6 DM8DBT6 DN ASP-0777 DM8DBT6 MI TT9IK2Z DM8DBT6 MN N-methyl-D-aspartate receptor (NMDAR) DM8DBT6 MT DTT DM8DBT6 MA Modulator DM8DBT6 RN US patent application no. 2011,0262,442, Compositions for treating cns disorders. DM8DBT6 RU https://www.google.com/patents/US20110262442 DMC80LV DI DMC80LV DMC80LV DN ASP1948 DMC80LV MI TTIPJCB DMC80LV MN Neuropilin-1 (NRP1) DMC80LV MT DTT DMC80LV MA Inhibitor DMC80LV RN National Cancer Institute Drug Dictionary (drug name ASP1948). DMC80LV RU https://www.cancer.gov/publications/dictionaries/cancer-drug/def/anti-nrp1-antibody-asp1948 DMX4PWV DI DMX4PWV DMX4PWV DN ASP1951 DMX4PWV MI TTG6LA7 DMX4PWV MN Activation-inducible TNFR family receptor (TNFRSF18) DMX4PWV MT DTT DMX4PWV MA Agonist DMX4PWV RN ClinicalTrials.gov (NCT03799003) A Study of ASP1951 in Subjects With Advanced Solid Tumors. U.S. National Institutes of Health. DMX4PWV RU https://clinicaltrials.gov/ct2/show/NCT03799003 DMW72NJ DI DMW72NJ DMW72NJ DN ASP3026 DMW72NJ MI TTPMQSO DMW72NJ MN ALK tyrosine kinase receptor (ALK) DMW72NJ MT DTT DMW72NJ MA Modulator DMW72NJ RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7740). DMW72NJ RU http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=7740 DM1RD0T DI DM1RD0T DM1RD0T DN ASP-4058 DM1RD0T MI TT9JZCK DM1RD0T MN Sphingosine-1-phosphate receptor 1 (S1PR1) DM1RD0T MT DTT DM1RD0T MA Modulator DM1RD0T RN ASP4058, a novel agonist for sphingosine 1-phosphate receptors 1 and 5, ameliorates rodent experimental autoimmune encephalomyelitis with a favorable safety profile. PLoS One. 2014 Oct 27;9(10):e110819. DM1RD0T RU https://pubmed.ncbi.nlm.nih.gov/25347187 DM1RD0T DI DM1RD0T DM1RD0T DN ASP-4058 DM1RD0T MI TTDZCKV DM1RD0T MN Sphingosine-1-phosphate receptor 5 (S1PR5) DM1RD0T MT DTT DM1RD0T MA Modulator DM1RD0T RN ASP4058, a novel agonist for sphingosine 1-phosphate receptors 1 and 5, ameliorates rodent experimental autoimmune encephalomyelitis with a favorable safety profile. PLoS One. 2014 Oct 27;9(10):e110819. DM1RD0T RU https://pubmed.ncbi.nlm.nih.gov/25347187 DMA71OL DI DMA71OL DMA71OL DN ASP8374 DMA71OL MI TTWNL74 DMA71OL MN V-set and immunoglobulin domain-containing protein 9 (TIGIT) DMA71OL MT DTT DMA71OL MA Antagonist DMA71OL RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMA71OL RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DMCDMPW DI DMCDMPW DMCDMPW DN ASP9801 DMCDMPW MI TTF89GD DMCDMPW MN Interleukin-2 (IL2) DMCDMPW MT DTT DMCDMPW RN Clinical pipeline report, company report or official report of Astellas Pharma. DMCDMPW RU https://www.astellas.com/system/files/2020-03/rdmeeting2019_pre_en2.pdf DMCDMPW DI DMCDMPW DMCDMPW DN ASP9801 DMCDMPW MI TT8FRMO DMCDMPW MN Interleukin-7 (IL7) DMCDMPW MT DTT DMCDMPW RN Clinical pipeline report, company report or official report of Astellas Pharma. DMCDMPW RU https://www.astellas.com/system/files/2020-03/rdmeeting2019_pre_en2.pdf DMCN7WI DI DMCN7WI DMCN7WI DN AST-005 DMCN7WI MI TTF8CQI DMCN7WI MN Tumor necrosis factor (TNF) DMCN7WI MT DTT DMCN7WI MA Inhibitor DMCN7WI RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMCN7WI RU http://phrma-docs.phrma.org/files/dmfile/MID_Skin_Diseases_2018_9_FINAL.pdf DM7C68W DI DM7C68W DM7C68W DN AST-008 DM7C68W MI TTSHG0T DM7C68W MN Toll-like receptor 9 (TLR9) DM7C68W MT DTT DM7C68W MA Agonist DM7C68W RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DM7C68W RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DMD83WO DI DMD83WO DMD83WO DN AST-1306 DMD83WO MI TTGKNB4 DMD83WO MN Epidermal growth factor receptor (EGFR) DMD83WO MT DTT DMD83WO MA Modulator DMD83WO RN AST1306, a novel irreversible inhibitor of the epidermal growth factor receptor 1 and 2, exhibits antitumor activity both in vitro and in vivo. PLoS One. 2011;6(7):e21487. DMD83WO RU https://pubmed.ncbi.nlm.nih.gov/21789172 DMD2BIT DI DMD2BIT DMD2BIT DN AT001/r84 DMD2BIT MI TTOHSBA DMD2BIT MN Vascular endothelial growth factor A (VEGFA) DMD2BIT MT DTT DMD2BIT RN Clinical pipeline report, company report or official report of Affitech (2011). DMD2BIT RU http://www.affitech.com/ DMYIPKJ DI DMYIPKJ DMYIPKJ DN AT13148 DMYIPKJ MI TTMQO60 DMYIPKJ MN Rho-associated protein kinase (ROCK) DMYIPKJ MT DTT DMYIPKJ MA Modulator DMYIPKJ RN Company report (Astex) DMYIPKJ RU http://www.astx.com/pipeline/products/clinical DM2B9E0 DI DM2B9E0 DM2B9E0 DN AT13387 DM2B9E0 MI TT78R5H DM2B9E0 MN Heat shock protein 90 alpha (HSP90A) DM2B9E0 MT DTT DM2B9E0 MA Inhibitor DM2B9E0 RN Astex Presents Updates on AT13387, its HSP90 Inhibitor, and AT9283, its Multi-Targeted Kinase Inhibitor at the EORTC-NCI-AACR Cancer Conference. Astex. 2008. DM2B9E0 RU http://www.drugs.com/clinical_trials/astex-presents-updates-at13387-hsp90-inhibitor-at9283-multi-targeted-kinase-inhibitor-eortc-nci-5775.html DMCE08M DI DMCE08M DMCE08M DN AT7519 DMCE08M MI TT7HF4W DMCE08M MN Cyclin-dependent kinase 2 (CDK2) DMCE08M MT DTT DMCE08M MA Inhibitor DMCE08M RN Biological characterization of AT7519, a small-molecule inhibitor of cyclin-dependent kinases, in human tumor cell lines. Mol Cancer Ther. 2009 Feb;8(2):324-32. DMCE08M RU https://pubmed.ncbi.nlm.nih.gov/19174555 DMHYO38 DI DMHYO38 DMHYO38 DN AT-787 DMHYO38 MI TTMVBWH DMHYO38 MN Hepatitis C virus RNA-directed RNA polymerase (HCV NS5B) DMHYO38 MT DTT DMHYO38 MA Inhibitor DMHYO38 RN Clinical pipeline report, company report or official report of Atea Pharmaceuticals. DMHYO38 RU https://ateapharma.com/about-us/hepatitis-c/ DM6O0TM DI DM6O0TM DM6O0TM DN ATA2271 DM6O0TM MI TT4RXME DM6O0TM MN Mesothelin (MSLN) DM6O0TM MT DTT DM6O0TM RN Clinical pipeline report, company report or official report of Atara Biotherapeutics. DM6O0TM RU https://www.atarabio.com/pipeline/ata2271-ata3271/ DMIMH8L DI DMIMH8L DMIMH8L DN ATD transdermal gel DMIMH8L MI TTZAYWL DMIMH8L MN Estrogen receptor (ESR) DMIMH8L MT DTT DMIMH8L MA Inhibitor DMIMH8L RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 620). DMIMH8L RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=620 DM96JTX DI DM96JTX DM96JTX DN ATEVIRDINE DM96JTX MI TT84ETX DM96JTX MN Human immunodeficiency virus Reverse transcriptase (HIV RT) DM96JTX MT DTT DM96JTX MA Modulator DM96JTX RN Targeting delavirdine/atevirdine resistant HIV-1: identification of (alkylamino)piperidine-containing bis(heteroaryl)piperazines as broad spectrum ... J Med Chem. 1996 Sep 13;39(19):3769-89. DM96JTX RU https://pubmed.ncbi.nlm.nih.gov/8809165 DMWGKHZ DI DMWGKHZ DMWGKHZ DN ATF-936 DMWGKHZ MI TTBUYHA DMWGKHZ MN Extracellular calcium-sensing receptor (CASR) DMWGKHZ MT DTT DMWGKHZ MA Antagonist DMWGKHZ RN ATF936, a novel oral calcilytic, increases bone mineral density in rats and transiently releases parathyroid hormone in humans. Bone. 2011 Aug;49(2):233-41. DMWGKHZ RU https://pubmed.ncbi.nlm.nih.gov/21514409 DMT5Z84 DI DMT5Z84 DMT5Z84 DN ATI-0917 DMT5Z84 MI TTF7I5O DMT5Z84 MN Human immunodeficiency virus Rev protein (HIV rev) DMT5Z84 MT DTT DMT5Z84 MA Inhibitor DMT5Z84 RN Antiretroviral drugs in development. A report from HIV DART 2008: Frontiers in Drug Development for Antiretroviral Therapies, 9-12 December 2008, Rio Grande, Puerto Rico. Expert Opin Investig Drugs. 2009 Apr;18(4):549-53. DMT5Z84 RU https://pubmed.ncbi.nlm.nih.gov/19335283 DMBKO2W DI DMBKO2W DMBKO2W DN ATI-355 DMBKO2W MI TT7GXMU DMBKO2W MN Reticulon-4 (RTN4) DMBKO2W MT DTT DMBKO2W RN Limiting multiple sclerosis related axonopathy by blocking Nogo receptor and CRMP-2 phosphorylation. Brain. 2012 June; 135(6): 1794-1818. DMBKO2W RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3589918/ DM6GKMU DI DM6GKMU DM6GKMU DN ATI-9242 DM6GKMU MI TTJQOD7 DM6GKMU MN 5-HT 2A receptor (HTR2A) DM6GKMU MT DTT DM6GKMU MA Modulator DM6GKMU RN Pharmacological characteristics of ATI-9242, a Novel Atypical Antipsychotic. FASEB J, April, 2010, 24(Meeting Abstract Supplement),773.12. DM6GKMU RU http://www.fasebj.org/cgi/content/meeting_abstract/24/1_MeetingAbstracts/773.12 DM6GKMU DI DM6GKMU DM6GKMU DN ATI-9242 DM6GKMU MI TTO9X1H DM6GKMU MN 5-HT 7 receptor (HTR7) DM6GKMU MT DTT DM6GKMU MA Modulator DM6GKMU RN Pharmacological characteristics of ATI-9242, a Novel Atypical Antipsychotic. FASEB J, April, 2010, 24(Meeting Abstract Supplement),773.12. DM6GKMU RU http://www.fasebj.org/cgi/content/meeting_abstract/24/1_MeetingAbstracts/773.12 DM6GKMU DI DM6GKMU DM6GKMU DN ATI-9242 DM6GKMU MI TTEX248 DM6GKMU MN Dopamine D2 receptor (D2R) DM6GKMU MT DTT DM6GKMU MA Modulator DM6GKMU RN Pharmacological characteristics of ATI-9242, a Novel Atypical Antipsychotic. FASEB J, April, 2010, 24(Meeting Abstract Supplement),773.12. DM6GKMU RU http://www.fasebj.org/cgi/content/meeting_abstract/24/1_MeetingAbstracts/773.12 DMR93S5 DI DMR93S5 DMR93S5 DN ATL1103 DMR93S5 MI TTHJWYD DMR93S5 MN GHR messenger RNA (GHR mRNA) DMR93S5 MT DTT DMR93S5 RN Clinical pipeline report, company report or official report of ISIS Pharmaceuticals (2009). DMR93S5 RU http://www.isispharm.com/Pipeline/index.htm DMZI4UX DI DMZI4UX DMZI4UX DN ATLCAR.CD30 cells DMZI4UX MI TT2GM5R DMZI4UX MN Lymphocyte activation antigen CD30 (TNFRSF8) DMZI4UX MT DTT DMZI4UX MA CAR-T-Cell-Therapy DMZI4UX RN ClinicalTrials.gov (NCT03602157) Study of CAR-T Cells Expressing CD30 and CCR4 for r/r CD30+ HL and NHL DMZI4UX RU https://clinicaltrials.gov/ct2/show/NCT03602157 DM3IPSX DI DM3IPSX DM3IPSX DN ATLCAR.CD30.CCR4 cells DM3IPSX MI TT7HQD0 DM3IPSX MN C-C chemokine receptor type 4 (CCR4) DM3IPSX MT DTT DM3IPSX MA CAR-T-Cell-Therapy(Dual specific) DM3IPSX RN ClinicalTrials.gov (NCT03602157) Study of CAR-T Cells Expressing CD30 and CCR4 for r/r CD30+ HL and NHL DM3IPSX RU https://clinicaltrials.gov/ct2/show/NCT03602157 DM3IPSX DI DM3IPSX DM3IPSX DN ATLCAR.CD30.CCR4 cells DM3IPSX MI TT2GM5R DM3IPSX MN Lymphocyte activation antigen CD30 (TNFRSF8) DM3IPSX MT DTT DM3IPSX MA CAR-T-Cell-Therapy(Dual specific) DM3IPSX RN ClinicalTrials.gov (NCT03602157) Study of CAR-T Cells Expressing CD30 and CCR4 for r/r CD30+ HL and NHL DM3IPSX RU https://clinicaltrials.gov/ct2/show/NCT03602157 DMU67HD DI DMU67HD DMU67HD DN ATR-01 DMU67HD MI TTK3C21 DMU67HD MN Acetoacetyl-CoA thiolase (ACAT1) DMU67HD MT DTT DMU67HD MA Inhibitor DMU67HD RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMU67HD RU http://phrma-docs.phrma.org/sites/default/files/pdf/medicines-in-development-drug-list-rare-diseases.pdf DMUMVXK DI DMUMVXK DMUMVXK DN ATR-101 DMUMVXK MI TT4V7ST DMUMVXK MN Sterol O-acyltransferase (SOAT) DMUMVXK MT DTT DMUMVXK MA Modulator DMUMVXK RN Company report (Atterocor) DMUMVXK RU http://atterocor.com/pdf/Atterocor-ENDO-PR-61214.pdf DMBCATZ DI DMBCATZ DMBCATZ DN ATR-107 DMBCATZ MI TTZO9B0 DMBCATZ MN Interleukin 21 receptor (IL21R) DMBCATZ MT DTT DMBCATZ RN Anti-IL21 receptor monoclonal antibody (ATR-107): Safety, pharmacokinetics, and pharmacodynamic evaluation in healthy volunteers: a phase I, first-in-human study. J Clin Pharmacol. 2014 Jan;54(1):14-22. DMBCATZ RU https://pubmed.ncbi.nlm.nih.gov/23913720 DMTG9EV DI DMTG9EV DMTG9EV DN ATRC-101 DMTG9EV MI TTHC8EF DMTG9EV MN Polyadenylate-binding protein 1 (PABPC1) DMTG9EV MT DTT DMTG9EV RN Clinical pipeline report, company report or official report of Atreca. DMTG9EV RU https://www.atreca.com/pipeline/ DML4SIE DI DML4SIE DML4SIE DN Atu-027 DML4SIE MI TTW3P4R DML4SIE MN Protein kinase N3 (PKN3) DML4SIE MT DTT DML4SIE MA Modulator DML4SIE RN Company report (Silence Therapeutics) DML4SIE RU http://www.silence-therapeutics.com/pipeline/?doing_wp_cron=1455613779.0401461124420166015625#AboutAtu027 DMKNMAE DI DMKNMAE DMKNMAE DN Autologous Anti-BCMA-CAR-expressing CD4+/CD8+ T-lymphocytes FCARH143 DMKNMAE MI TTZ3P4W DMKNMAE MN B-cell maturation protein (TNFRSF17) DMKNMAE MT DTT DMKNMAE MA CAR-T-Cell-Therapy DMKNMAE RN ClinicalTrials.gov (NCT03338972) Immunotherapy With BCMA CAR-T Cells in Treating Patients With BCMA Positive Relapsed or Refractory Multiple Myeloma DMKNMAE RU https://clinicaltrials.gov/ct2/show/NCT03338972 DMQA1VT DI DMQA1VT DMQA1VT DN Autologous cell based gene therapy DMQA1VT MI TTCM4B3 DMQA1VT MN Nitric-oxide synthase endothelial (NOS3) DMQA1VT MT DTT DMQA1VT MA Modulator DMQA1VT RN Feasibility of using autologous transplantation to evaluate hematopoietic stem cell-based gene therapy strategies in transgenic mouse models of human disease. Mol Ther. 2002 Sep;6(3):422-8. DMQA1VT RU https://pubmed.ncbi.nlm.nih.gov/12231180 DMJW4TP DI DMJW4TP DMJW4TP DN Autologous ET1402L1-CART cells DMJW4TP MI TT3WAD0 DMJW4TP MN HLA-A02/AFP complex (HLA-A02/AFP) DMJW4TP MT DTT DMJW4TP MA CAR-T-Cell-Therapy DMJW4TP RN ClinicalTrials.gov (NCT03349255) Clinical Study of ET1402L1-CAR T Cells in AFP Expressing Hepatocellular Carcinoma DMJW4TP RU https://clinicaltrials.gov/ct2/show/NCT03349255 DMARYFK DI DMARYFK DMARYFK DN Autologous melanoma cell vaccine DMARYFK MI TTNYZG2 DMARYFK MN Granulocyte-macrophage colony-stimulating factor (CSF2) DMARYFK MT DTT DMARYFK MA Modulator DMARYFK RN Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41. DMARYFK RU https://www.ncbi.nlm.nih.gov/pubmed/15950434 DMZ763A DI DMZ763A DMZ763A DN Autologous T Cells Expressing MET scFv CAR DMZ763A MI TTNDSF4 DMZ763A MN Proto-oncogene c-Met (MET) DMZ763A MT DTT DMZ763A MA CAR-T-Cell-Therapy DMZ763A RN ClinicalTrials.gov (NCT03060356) Autologous T Cells Expressing MET scFv CAR (RNA CART-cMET) DMZ763A RU https://clinicaltrials.gov/ct2/show/NCT03060356 DMTLU37 DI DMTLU37 DMTLU37 DN Autologous T cells transfected with chimeric anti-mesothelin immunoreceptor SS1 DMTLU37 MI TT4RXME DMTLU37 MN Mesothelin (MSLN) DMTLU37 MT DTT DMTLU37 MA CAR-T-Cell-Therapy DMTLU37 RN ClinicalTrials.gov (NCT01897415) Autologous Redirected RNA Meso CAR T Cells for Pancreatic Cancer DMTLU37 RU https://clinicaltrials.gov/ct2/show/NCT01897415 DMOAET3 DI DMOAET3 DMOAET3 DN Autologous T-cell therapy DMOAET3 MI TT9G4N0 DMOAET3 MN Glutamate carboxypeptidase II (GCPII) DMOAET3 MT DTT DMOAET3 RN Antitumor activities of PSMA CD3 diabodies by redirected T-cell lysis of prostate cancer cells. Immunotherapy. 2013 Jan;5(1):27-38. DMOAET3 RU https://pubmed.ncbi.nlm.nih.gov/23256796 DMOAET3 DI DMOAET3 DMOAET3 DN Autologous T-cell therapy DMOAET3 MI TTZAT79 DMOAET3 MN T-cell surface glycoprotein CD3 epsilon (CD3E) DMOAET3 MT DTT DMOAET3 RN Antitumor activities of PSMA CD3 diabodies by redirected T-cell lysis of prostate cancer cells. Immunotherapy. 2013 Jan;5(1):27-38. DMOAET3 RU https://pubmed.ncbi.nlm.nih.gov/23256796 DMOAET3 DI DMOAET3 DMOAET3 DN Autologous T-cell therapy DMOAET3 MI TTV3XPL DMOAET3 MN T-cell surface glycoprotein CD3 gamma (CD3G) DMOAET3 MT DTT DMOAET3 RN Antitumor activities of PSMA CD3 diabodies by redirected T-cell lysis of prostate cancer cells. Immunotherapy. 2013 Jan;5(1):27-38. DMOAET3 RU https://pubmed.ncbi.nlm.nih.gov/23256796 DMZLCTD DI DMZLCTD DMZLCTD DN AV-203 DMZLCTD MI TTDC8N2 DMZLCTD MN Erbb3 tyrosine kinase receptor (Erbb-3) DMZLCTD MT DTT DMZLCTD RN Neuregulin 1 expression is a predictive biomarker for response to AV-203, an ERBB3 inhibitory antibody, in human tumor models. Clin Cancer Res. 2015 Mar 1;21(5):1106-14. DMZLCTD RU https://pubmed.ncbi.nlm.nih.gov/25542901 DME630T DI DME630T DME630T DN AV4025 DME630T MI TTCJ2X8 DME630T MN Hepatitis C virus Non-structural 5A (HCV NS5A) DME630T MT DTT DME630T MA Modulator DME630T RN Discovery of novel highly potent hepatitis C virus NS5A inhibitor (AV4025). J Med Chem. 2014 Sep 25;57(18):7716-30. DME630T RU https://pubmed.ncbi.nlm.nih.gov/25148100 DMVL87N DI DMVL87N DMVL87N DN AV-965 DMVL87N MI TTSQIFT DMVL87N MN 5-HT 1A receptor (HTR1A) DMVL87N MT DTT DMVL87N MA Antagonist DMVL87N RN Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800025412) DMVL87N RU http://adisinsight.springer.com/drugs/800025412 DMKCRMD DI DMKCRMD DMKCRMD DN AVB-S6-500 DMKCRMD MI TTZPY6J DMKCRMD MN Tyrosine-protein kinase UFO (AXL) DMKCRMD MT DTT DMKCRMD MA Inhibitor DMKCRMD RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMKCRMD RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DMSR91U DI DMSR91U DMSR91U DN AVE0118 DMSR91U MI TT1VOHK DMSR91U MN Potassium channel unspecific (KC) DMSR91U MT DTT DMSR91U MA Modulator DMSR91U RN Neurogenic contraction induced by the antiarrhythmic compound, AVE 0118, in rat small mesenteric arteries.Basic Clin Pharmacol Toxicol.2014 Oct;115(4):315-20. DMSR91U RU https://www.ncbi.nlm.nih.gov/pubmed/24629214 DM56VG2 DI DM56VG2 DM56VG2 DN AVE0897 DM56VG2 MI TTJ584C DM56VG2 MN Peroxisome proliferator-activated receptor alpha (PPARA) DM56VG2 MT DTT DM56VG2 MA Agonist DM56VG2 RN Pharma & Vaccines. Product Development Pipeline. April 29 2009. DM56VG2 RU http://en.sanofi-aventis.com/binaries/RD_Phase_III_EN_tcm28-24007.pdf DMJY35M DI DMJY35M DMJY35M DN AVE1701 DMJY35M MI TTC24WT DMJY35M MN C-C chemokine receptor type 1 (CCR1) DMJY35M MT DTT DMJY35M MA Antagonist DMJY35M RN Emerging drugs for rheumatoid arthritis. Expert Opin Emerg Drugs. 2008 Mar;13(1):175-96. DMJY35M RU https://pubmed.ncbi.nlm.nih.gov/18321156 DMZNTHJ DI DMZNTHJ DMZNTHJ DN AVE-8112 DMZNTHJ MI TTZ97H5 DMZNTHJ MN Phosphodiesterase 4A (PDE4A) DMZNTHJ MT DTT DMZNTHJ MA Inhibitor DMZNTHJ RN Therapy for Parkinson's Disease: What is in the Pipeline . Neurotherapeutics. 2014 January; 11(1): 24-33. DMZNTHJ RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3899489/ DMZNTHJ DI DMZNTHJ DMZNTHJ DN AVE-8112 DMZNTHJ MI TTVIAT9 DMZNTHJ MN Phosphodiesterase 4B (PDE4B) DMZNTHJ MT DTT DMZNTHJ MA Inhibitor DMZNTHJ RN Therapy for Parkinson's Disease: What is in the Pipeline . Neurotherapeutics. 2014 January; 11(1): 24-33. DMZNTHJ RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3899489/ DMZNTHJ DI DMZNTHJ DMZNTHJ DN AVE-8112 DMZNTHJ MI TTSKMI8 DMZNTHJ MN Phosphodiesterase 4D (PDE4D) DMZNTHJ MT DTT DMZNTHJ MA Inhibitor DMZNTHJ RN Therapy for Parkinson's Disease: What is in the Pipeline . Neurotherapeutics. 2014 January; 11(1): 24-33. DMZNTHJ RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3899489/ DMVUW8A DI DMVUW8A DMVUW8A DN AVI-6002 DMVUW8A MI TTDJLWQ DMVUW8A MN Ebola virus VP24 messenger RNA (EV VP24 mRNA) DMVUW8A MT DTT DMVUW8A MA Modulator DMVUW8A RN Discovery and Early Development of AVI-7537 and AVI-7288 for the Treatment of Ebola Virus and Marburg Virus Infections. Viruses. 2012 November; 4(11): 2806-2830. DMVUW8A RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3509674/ DMVUW8A DI DMVUW8A DMVUW8A DN AVI-6002 DMVUW8A MI TT3Z102 DMVUW8A MN Ebola virus VP35 messenger RNA (EV VP35 mRNA) DMVUW8A MT DTT DMVUW8A MA Modulator DMVUW8A RN Discovery and Early Development of AVI-7537 and AVI-7288 for the Treatment of Ebola Virus and Marburg Virus Infections. Viruses. 2012 November; 4(11): 2806-2830. DMVUW8A RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3509674/ DMIJSDO DI DMIJSDO DMIJSDO DN AVI-6003 DMIJSDO MI TTDJLWQ DMIJSDO MN Ebola virus VP24 messenger RNA (EV VP24 mRNA) DMIJSDO MT DTT DMIJSDO MA Modulator DMIJSDO RN Discovery and Early Development of AVI-7537 and AVI-7288 for the Treatment of Ebola Virus and Marburg Virus Infections. Viruses. 2012 November; 4(11): 2806-2830. DMIJSDO RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3509674/ DMIJSDO DI DMIJSDO DMIJSDO DN AVI-6003 DMIJSDO MI TT3Z102 DMIJSDO MN Ebola virus VP35 messenger RNA (EV VP35 mRNA) DMIJSDO MT DTT DMIJSDO MA Modulator DMIJSDO RN Discovery and Early Development of AVI-7537 and AVI-7288 for the Treatment of Ebola Virus and Marburg Virus Infections. Viruses. 2012 November; 4(11): 2806-2830. DMIJSDO RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3509674/ DMVD327 DI DMVD327 DMVD327 DN AVI-7288 DMVD327 MI TT1E5A4 DMVD327 MN Marburg virus NP messenger RNA (MV NP mRNA) DMVD327 MT DTT DMVD327 RN AVI-7288 for Marburg Virus in Nonhuman Primates and Humans. N Engl J Med. 2015 Jul 23;373(4):339-48. DMVD327 RU https://pubmed.ncbi.nlm.nih.gov/26200980 DMLI9U6 DI DMLI9U6 DMLI9U6 DN AVI-7537 DMLI9U6 MI TTDJLWQ DMLI9U6 MN Ebola virus VP24 messenger RNA (EV VP24 mRNA) DMLI9U6 MT DTT DMLI9U6 RN Discovery and Early Development of AVI-7537 and AVI-7288 for the Treatment of Ebola Virus and Marburg Virus Infections. Viruses. 2012 November; 4(11): 2806-2830. DMLI9U6 RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3509674/ DMZ39T6 DI DMZ39T6 DMZ39T6 DN AVID200 DMZ39T6 MI TTO3HT7 DMZ39T6 MN Transforming growth factor beta (TGFB) DMZ39T6 MT DTT DMZ39T6 MA Inhibitor DMZ39T6 RN TGF signaling underlies hematopoietic dysfunction and bone marrow failure in Shwachman-Diamond Syndrome. J Clin Invest. 2019 Jun 18;129(9):3821-3826. DMZ39T6 RU https://pubmed.ncbi.nlm.nih.gov/31211692 DMGAKR9 DI DMGAKR9 DMGAKR9 DN AVL-3288 DMGAKR9 MI TTLA931 DMGAKR9 MN Neuronal acetylcholine receptor alpha-7 (CHRNA7) DMGAKR9 MT DTT DMGAKR9 MA Modulator DMGAKR9 RN Differential immediate and sustained memory enhancing effects of alpha7 nicotinic receptor agonists and allosteric modulators in rats. PLoS One. 2011;6(11):e27014. DMGAKR9 RU https://pubmed.ncbi.nlm.nih.gov/22096516 DMNIVFJ DI DMNIVFJ DMNIVFJ DN AVN-322 DMNIVFJ MI TTJS8PY DMNIVFJ MN 5-HT 6 receptor (HTR6) DMNIVFJ MT DTT DMNIVFJ MA Antagonist DMNIVFJ RN AVN-322 is a Safe Orally Bio-Available Potent and Highly Selective Antagonist of 5-HT6R with Demonstrated Ability to Improve Impaired Memory in Animal Models. Curr Alzheimer Res. 2017;14(3):268-294. DMNIVFJ RU https://pubmed.ncbi.nlm.nih.gov/27829340 DM8CYJ1 DI DM8CYJ1 DM8CYJ1 DN AVP-13358 DM8CYJ1 MI TTYJQTF DM8CYJ1 MN Immunoglobulin E (IgE) DM8CYJ1 MT DTT DM8CYJ1 MA Inhibitor DM8CYJ1 RN Novel 2-(substituted phenyl)benzimidazole derivatives with potent activity against IgE, cytokines, and CD23 for the treatment of allergy and asthma. J Med Chem. 2004 Dec 16;47(26):6451-4. DM8CYJ1 RU https://pubmed.ncbi.nlm.nih.gov/15588078 DMMWEH6 DI DMMWEH6 DMMWEH6 DN AVP-21D9 DMMWEH6 MI TT3YGCD DMMWEH6 MN Bacterial Protective antigen (Bact pagA) DMMWEH6 MT DTT DMMWEH6 RN Efficacy and Safety of AVP-21D9, an Anthrax Monoclonal Antibody, in Animal Models and Humans. Antimicrob Agents Chemother. 2014 July; 58(7): 3618-3625. DMMWEH6 RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4068543/ DMAKD0I DI DMAKD0I DMAKD0I DN AVX-470 DMAKD0I MI TTF8CQI DMAKD0I MN Tumor necrosis factor (TNF) DMAKD0I MT DTT DMAKD0I MA Inhibitor DMAKD0I RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMAKD0I RU http://phrma-docs.phrma.org/files/dmfile/medicines-in-development-drug-list-autoimmune-diseases.pdf DMAKD0I DI DMAKD0I DMAKD0I DN AVX-470 DMAKD0I MI TTG043C DMAKD0I MN Tumor necrosis factor receptor type I (TNF-R1) DMAKD0I MT DTT DMAKD0I RN Secretion of a TNFR:Fc fusion protein following pulmonary administration of pseudotyped adeno-associated virus vectors. J Virol. 2004 Nov;78(22):12355-65. DMAKD0I RU https://pubmed.ncbi.nlm.nih.gov/15507622 DMRQ32K DI DMRQ32K DMRQ32K DN AX-024 DMRQ32K MI TTMA3VF DMRQ32K MN NCK adaptor protein 1 (NCK1) DMRQ32K MT DTT DMRQ32K MA Modulator DMRQ32K RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMRQ32K RU http://phrma-docs.phrma.org/files/dmfile/medicines-in-development-drug-list-autoimmune-diseases.pdf DMRQ32K DI DMRQ32K DMRQ32K DN AX-024 DMRQ32K MI TTXQYT6 DMRQ32K MN T-cells (T-cells) DMRQ32K MT DTT DMRQ32K MA Inhibitor DMRQ32K RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMRQ32K RU http://phrma-docs.phrma.org/files/dmfile/medicines-in-development-drug-list-autoimmune-diseases.pdf DMFBMU7 DI DMFBMU7 DMFBMU7 DN Axatilamab DMFBMU7 MI TT7MRDV DMFBMU7 MN Macrophage colony-stimulating factor 1 receptor (CSF1R) DMFBMU7 MT DTT DMFBMU7 MA Antagonist DMFBMU7 RN Clinical pipeline report, company report or official report of Syndax Pharmaceuticals. DMFBMU7 RU https://syndax.com/pipeline/axatilimab/ DM6L5IP DI DM6L5IP DM6L5IP DN Axitirome DM6L5IP MI TTGER3L DM6L5IP MN Thyroid hormone receptor beta (THRB) DM6L5IP MT DTT DM6L5IP MA Modulator DM6L5IP RN Bacterial biosensors for screening isoform-selective ligands for human thyroid receptors alpha-1 and beta-1. FEBS Open Bio. 2012; 2: 247-253. DM6L5IP RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3642162/ DM7ZU3B DI DM7ZU3B DM7ZU3B DN AXT-914 DM7ZU3B MI TTBUYHA DM7ZU3B MN Extracellular calcium-sensing receptor (CASR) DM7ZU3B MT DTT DM7ZU3B MA Antagonist DM7ZU3B RN AXT914 a novel, orally-active parathyroid hormone-releasing drug in two early studies of healthy volunteers and postmenopausal women. Bone. 2014 Jul;64:204-10. DM7ZU3B RU https://pubmed.ncbi.nlm.nih.gov/24769332 DMWCJEU DI DMWCJEU DMWCJEU DN AZD0156 DMWCJEU MI TTKBM7V DMWCJEU MN ATM serine/threonine kinase (ATM) DMWCJEU MT DTT DMWCJEU MA Inhibitor DMWCJEU RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMWCJEU RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DMHBEKM DI DMHBEKM DMHBEKM DN AZD0284 DMHBEKM MI TTGV6LY DMHBEKM MN Nuclear receptor ROR-gamma (RORG) DMHBEKM MT DTT DMHBEKM MA Agonist DMHBEKM RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMHBEKM RU http://phrma-docs.phrma.org/files/dmfile/MID_Skin_Diseases_2018_9_FINAL.pdf DMMW72C DI DMMW72C DMMW72C DN AZD-1152-HQPA DMMW72C MI TT5LS6T DMMW72C MN Aurora kinase B (AURKB) DMMW72C MT DTT DMMW72C MA Modulator DMMW72C RN Phase I study of barasertib (AZD1152), a selective inhibitor of Aurora B kinase, in patients with advanced solid tumors.Invest New Drugs.2013 Apr;31(2):370-80. DMMW72C RU https://www.ncbi.nlm.nih.gov/pubmed/22661287 DMBEA6V DI DMBEA6V DMBEA6V DN AZD1208 DMBEA6V MI TT69J2Z DMBEA6V MN Serine/threonine-protein kinase pim-2 (PIM2) DMBEA6V MT DTT DMBEA6V MA Modulator DMBEA6V RN AZD1208, a potent and selective pan-Pim kinase inhibitor, demonstrates efficacy in preclinical models of acute myeloid leukemia. Blood. 2014 Feb 6;123(6):905-13. DMBEA6V RU https://pubmed.ncbi.nlm.nih.gov/24363397 DMYBX4N DI DMYBX4N DMYBX4N DN AZD1390 DMYBX4N MI TTKBM7V DMYBX4N MN ATM serine/threonine kinase (ATM) DMYBX4N MT DTT DMYBX4N MA Inhibitor DMYBX4N RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMYBX4N RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DM6UOXF DI DM6UOXF DM6UOXF DN AZD1419 DM6UOXF MI TTSHG0T DM6UOXF MN Toll-like receptor 9 (TLR9) DM6UOXF MT DTT DM6UOXF MA Agonist DM6UOXF RN Clinical pipeline report, company report or official report of dynavax. DM6UOXF RU http://investors.dynavax.com/releasedetail.cfm?releaseid=611310 DMQ1OX4 DI DMQ1OX4 DMQ1OX4 DN AZD1979 DMQ1OX4 MI TTX4RTB DMQ1OX4 MN Melanin-concentrating hormone receptor 1 (MCHR1) DMQ1OX4 MT DTT DMQ1OX4 MA Modulator DMQ1OX4 RN Phase I clinical trial of AZD1979 for treating obesity. AstraZeneca plc DMQ1OX4 RU http://www.biocentury.com/products/azd1979 DMZQEDY DI DMZQEDY DMZQEDY DN AZD-2551 DMZQEDY MI TTZBFA0 DMZQEDY MN Protease unspecific (PRO) DMZQEDY MT DTT DMZQEDY MA Inhibitor DMZQEDY RN Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800029854) DMZQEDY RU http://adisinsight.springer.com/drugs/800029854 DMXFYN0 DI DMXFYN0 DMXFYN0 DN AZD-3043 DMXFYN0 MI TTEX6LM DMXFYN0 MN GABA(A) receptor gamma-3 (GABRG3) DMXFYN0 MT DTT DMXFYN0 MA Modulator DMXFYN0 RN AZD-3043: a novel, metabolically labile sedative-hypnotic agent with rapid and predictable emergence from hypnosis. Anesthesiology. 2012 Jun;116(6):1267-77. DMXFYN0 RU https://pubmed.ncbi.nlm.nih.gov/22531340 DMICW7D DI DMICW7D DMICW7D DN AZD-3161 DMICW7D MI TTRK8B9 DMICW7D MN Sodium channel unspecific (NaC) DMICW7D MT DTT DMICW7D MA Modulator DMICW7D RN Recent progress in sodium channel modulators for pain.Bioorganic & Medicinal Chemistry Letters Volume 24, Issue 16, 15 August 2014, Pages 3690-3699. DMICW7D RU http://www.sciencedirect.com/science/article/pii/S0960894X14006660 DMC1BXV DI DMC1BXV DMC1BXV DN AZD-3514 DMC1BXV MI TTS64P2 DMC1BXV MN Androgen receptor (AR) DMC1BXV MT DTT DMC1BXV MA Antagonist DMC1BXV RN AZD3514: a small molecule that modulates androgen receptor signaling and function in vitro and in vivo. Mol Cancer Ther. 2013 Sep;12(9):1715-27. DMC1BXV RU https://pubmed.ncbi.nlm.nih.gov/23861347 DM72FOD DI DM72FOD DM72FOD DN Azd-3839 DM72FOD MI TT8JRS7 DM72FOD MN Beta-secretase (BACE) DM72FOD MT DTT DM72FOD MA Inhibitor DM72FOD RN Discovery of AZD3839, a potent and selective BACE1 inhibitor clinical candidate for the treatment of Alzheimer disease. J Biol Chem. 2012 Nov 30;287(49):41245-57. DM72FOD RU https://pubmed.ncbi.nlm.nih.gov/23048024 DM72FOD DI DM72FOD DM72FOD DN Azd-3839 DM72FOD MI DE4LYSA DM72FOD MN Cytochrome P450 3A4 (CYP3A4) DM72FOD MT DME DM72FOD MA Metabolism DM72FOD RN MedChemExpress: AZD3839. DM72FOD RU https://www.medchemexpress.com/AZD3839-free-base.html DMOYPTK DI DMOYPTK DMOYPTK DN AZD4573 DMOYPTK MI TT1LVF2 DMOYPTK MN Cyclin-dependent kinase 9 (CDK9) DMOYPTK MT DTT DMOYPTK MA Inhibitor DMOYPTK RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMOYPTK RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DM36EY7 DI DM36EY7 DM36EY7 DN AZD4721 DM36EY7 MI TT30C9G DM36EY7 MN C-X-C chemokine receptor type 2 (CXCR2) DM36EY7 MT DTT DM36EY7 MA Antagonist DM36EY7 RN Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800038326) DM36EY7 RU http://adisinsight.springer.com/drugs/800038326 DMVWMUK DI DMVWMUK DMVWMUK DN AZD4785 DMVWMUK MI TTB1RA4 DMVWMUK MN GTPase KRas (KRAS) DMVWMUK MT DTT DMVWMUK MA Inhibitor DMVWMUK RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMVWMUK RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DMRP3N8 DI DMRP3N8 DMRP3N8 DN AZD4831 DMRP3N8 MI TTVCZPI DMRP3N8 MN Myeloperoxidase (MPO) DMRP3N8 MT DTT DMRP3N8 MA Modulator DMRP3N8 RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMRP3N8 RU http://phrma-docs.phrma.org/files/dmfile/2018_Heart-Disease-and-Stroke_MID-Drug-List.pdf DMQEO4V DI DMQEO4V DMQEO4V DN AZD-5122 DMQEO4V MI TT30C9G DMQEO4V MN C-X-C chemokine receptor type 2 (CXCR2) DMQEO4V MT DTT DMQEO4V MA Modulator DMQEO4V RN Molecular Approaches To Target GPCRs in Cancer Therapy. Pharmaceuticals 2011, 4(4), 567-589. DMQEO4V RU http://www.mdpi.com/1424-8247/4/4/567 DMW4GM2 DI DMW4GM2 DMW4GM2 DN AZD5153 DMW4GM2 MI TTRA6BO DMW4GM2 MN Bromodomain-containing protein 4 (BRD4) DMW4GM2 MT DTT DMW4GM2 MA Inhibitor DMW4GM2 RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMW4GM2 RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DMBQ2TF DI DMBQ2TF DMBQ2TF DN AZD-5438 DMBQ2TF MI TT7HF4W DMBQ2TF MN Cyclin-dependent kinase 2 (CDK2) DMBQ2TF MT DTT DMBQ2TF MA Modulator DMBQ2TF RN AZD5438, an inhibitor of Cdk1, 2, and 9, enhances the radiosensitivity of non-small cell lung carcinoma cells.Int J Radiat Oncol Biol Phys.2012 Nov 15;84(4):e507-14. DMBQ2TF RU https://www.ncbi.nlm.nih.gov/pubmed/22795803 DMV6DF3 DI DMV6DF3 DMV6DF3 DN AZD5658 DMV6DF3 MI TTDLNGZ DMV6DF3 MN Glucokinase (GCK) DMV6DF3 MT DTT DMV6DF3 MA Activator DMV6DF3 RN Clinical pipeline report, company report or official report of AstraZeneca (2011). DMV6DF3 RU http://www.astrazeneca.com/Home DM7QGHO DI DM7QGHO DM7QGHO DN AZD5991 DM7QGHO MI TTL53M6 DM7QGHO MN Induced myeloid leukemia cell differentiation protein Mcl-1 (MCL1) DM7QGHO MT DTT DM7QGHO MA Inhibitor DM7QGHO RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DM7QGHO RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DM0WCR4 DI DM0WCR4 DM0WCR4 DN AZD-6088 DM0WCR4 MI TTZ9SOR DM0WCR4 MN Muscarinic acetylcholine receptor M1 (CHRM1) DM0WCR4 MT DTT DM0WCR4 MA Agonist DM0WCR4 RN Evaluation of an Innovative Population Pharmacokinetic-Based Design for Behavioral Pharmacodynamic Endpoints. AAPS J. 2012 December; 14(4): 657-663. DM0WCR4 RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3475849/ DMW4VQF DI DMW4VQF DMW4VQF DN AZD6423 DMW4VQF MI TT9IK2Z DMW4VQF MN N-methyl-D-aspartate receptor (NMDAR) DMW4VQF MT DTT DMW4VQF MA Antagonist DMW4VQF RN Biology of the NMDA Receptor. Marie L. Blanke and Antonius M.J. VanDongen. 2009. DMW4VQF RU http://www.ncbi.nlm.nih.gov/books/NBK5283/ DM84WXZ DI DM84WXZ DM84WXZ DN AZD-7295 DM84WXZ MI TTCJ2X8 DM84WXZ MN Hepatitis C virus Non-structural 5A (HCV NS5A) DM84WXZ MT DTT DM84WXZ MA Modulator DM84WXZ RN TARGETING THE NS5A PROTEIN OF HCV: AN EMERGING OPTION. Drugs Future. 2011 September; 36(9): 691-711. DM84WXZ RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3558953/ DMS9I6A DI DMS9I6A DMS9I6A DN AZD7687 DMS9I6A MI TTF8P9I DMS9I6A MN Diacylglycerol acyltransferase 1 (DGAT1) DMS9I6A MT DTT DMS9I6A MA Inhibitor DMS9I6A RN Clinical pipeline report, company report or official report of AstraZeneca (2011). DMS9I6A RU http://www.astrazeneca.com/Home DM1FW0C DI DM1FW0C DM1FW0C DN AZD7762 DM1FW0C MI TTTU902 DM1FW0C MN Checkpoint kinase-1 (CHK1) DM1FW0C MT DTT DM1FW0C MA Inhibitor DM1FW0C RN Clinical pipeline report, company report or official report of AstraZeneca (2009). DM1FW0C RU http://www.astrazeneca.com/_mshost3690701/content/resources/media/investors/AZN-Q2-2009/AZN-Q2-2009-Pipeline.pdf DM8DMI0 DI DM8DMI0 DM8DMI0 DN AZD-8165 DM8DMI0 MI TT6L509 DM8DMI0 MN Coagulation factor IIa (F2) DM8DMI0 MT DTT DM8DMI0 MA Inhibitor DM8DMI0 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2362). DM8DMI0 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2362 DMWYF1H DI DMWYF1H DMWYF1H DN AZD8186 DMWYF1H MI TTTHBCA DMWYF1H MN PI3-kinase beta (PIK3CB) DMWYF1H MT DTT DMWYF1H MA Inhibitor DMWYF1H RN National Cancer Institute Drug Dictionary (drug id 751594). DMWYF1H RU http://www.cancer.gov/publications/dictionaries/cancer-drug?cdrid=751594 DMWYF1H DI DMWYF1H DMWYF1H DN AZD8186 DMWYF1H MI TTHBTOP DMWYF1H MN PI3-kinase gamma (PIK3CG) DMWYF1H MT DTT DMWYF1H MA Inhibitor DMWYF1H RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMWYF1H RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DMTD57A DI DMTD57A DMTD57A DN AZD8329 DMTD57A MI TTN7BL9 DMTD57A MN Corticosteroid 11-beta-dehydrogenase 1 (HSD11B1) DMTD57A MT DTT DMTD57A MA Inhibitor DMTD57A RN Clinical pipeline report, company report or official report of AstraZeneca (2011). DMTD57A RU http://www.astrazeneca.com/Home DM9X20P DI DM9X20P DM9X20P DN AZD-8418 DM9X20P MI TTAN6JD DM9X20P MN Glutamate receptor AMPA (GRIA) DM9X20P MT DTT DM9X20P MA Modulator DM9X20P RN Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800031633) DM9X20P RU http://adisinsight.springer.com/drugs/800031633 DM3EWUX DI DM3EWUX DM3EWUX DN AZD8701 DM3EWUX MI TT1X3QF DM3EWUX MN FOXP3 messenger RNA (FOXP3 mRNA) DM3EWUX MT DTT DM3EWUX MA Inhibitor DM3EWUX RN Clinical pipeline report, company report or official report of Ionis Pharmaceuticals. DM3EWUX RU https://www.ionispharma.com/ionis-innovation/pipeline/ DMPMDTH DI DMPMDTH DMPMDTH DN Azd9496 DMPMDTH MI DES5XRU DMPMDTH MN Cytochrome P450 2C8 (CYP2C8) DMPMDTH MT DME DMPMDTH MA Metabolism DMPMDTH RN Complete substrate inhibition of cytochrome P450 2C8 by AZD9496, an oral selective estrogen receptor degrader. Drug Metab Dispos. 2018 Sep;46(9):1268-1276. DMPMDTH RU https://www.ncbi.nlm.nih.gov/pubmed/?term=29921707 DMPMDTH DI DMPMDTH DMPMDTH DN Azd9496 DMPMDTH MI TTZAYWL DMPMDTH MN Estrogen receptor (ESR) DMPMDTH MT DTT DMPMDTH MA Antagonist DMPMDTH RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMPMDTH RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DMAXHC0 DI DMAXHC0 DMAXHC0 DN AZD9567 DMAXHC0 MI TTOZRK6 DMAXHC0 MN Glucocorticoid receptor messenger RNA (GCR mRNA) DMAXHC0 MT DTT DMAXHC0 MA Modulator DMAXHC0 RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMAXHC0 RU http://phrma-docs.phrma.org/files/dmfile/medicines-in-development-drug-list-autoimmune-diseases.pdf DMWYHXG DI DMWYHXG DMWYHXG DN AZD-9819 DMWYHXG MI TTPLTSQ DMWYHXG MN Neutrophil elastase (NE) DMWYHXG MT DTT DMWYHXG MA Inhibitor DMWYHXG RN Lipid Peroxide-Mediated Oxidative Rearrangement of the Pyrazinone Carboxamide Core of Neutrophil Elastase Inhibitor AZD9819 in Blood Plasma Samples. Drug Metab Dispos. 2015 Oct;43(10):1441-9. DMWYHXG RU https://pubmed.ncbi.nlm.nih.gov/26203069 DM0LKHV DI DM0LKHV DM0LKHV DN B7-2/GM-CSF DM0LKHV MI TTZ9SOR DM0LKHV MN Muscarinic acetylcholine receptor M1 (CHRM1) DM0LKHV MT DTT DM0LKHV MA Agonist DM0LKHV RN Clinical pipeline report, company report or official report of GlaxoSmithKline (2009). DM0LKHV RU http://www.gsk.com/investors/product_pipeline/docs/gsk-pipeline-feb09.pdf DM0LKHV DI DM0LKHV DM0LKHV DN B7-2/GM-CSF DM0LKHV MI TTQWUPT DM0LKHV MN Thyroid hormone receptor (THR) DM0LKHV MT DTT DM0LKHV MA Agonist DM0LKHV RN Sobetirome: a case history of bench-to-clinic drug discovery and development. Heart Fail Rev. 2010 Mar;15(2):177-82. DM0LKHV RU https://pubmed.ncbi.nlm.nih.gov/19002578 DM5KU30 DI DM5KU30 DM5KU30 DN BAL-30072 DM5KU30 MI TTJP4SM DM5KU30 MN Bacterial Penicillin binding protein (Bact PBP) DM5KU30 MT DTT DM5KU30 MA Inhibitor DM5KU30 RN In vitro properties of BAL30072, a novel siderophore sulfactam with activity against multiresistant gram-negative bacilli. Antimicrob Agents Chemother. 2010 Jun;54(6):2291-302. DM5KU30 RU https://pubmed.ncbi.nlm.nih.gov/20308379 DMAJPOX DI DMAJPOX DMAJPOX DN Balapiravir DMAJPOX MI TTMVBWH DMAJPOX MN Hepatitis C virus RNA-directed RNA polymerase (HCV NS5B) DMAJPOX MT DTT DMAJPOX MA Inhibitor DMAJPOX RN R-1626, a specific oral NS5B polymerase inhibitor of hepatitis C virus. IDrugs. 2008 Oct;11(10):738-49. DMAJPOX RU https://pubmed.ncbi.nlm.nih.gov/18828074 DM3415L DI DM3415L DM3415L DN BAX-499 DM3415L MI TT068JH DM3415L MN Tissue factor pathway inhibitor (TFPI) DM3415L MT DTT DM3415L MA Inhibitor DM3415L RN Aptamer BAX 499 mediates inhibition of tissue factor pathway inhibitor via interaction with multiple domains of the protein. J Thromb Haemost. 2013 Jun;11(6):1137-45. DM3415L RU https://pubmed.ncbi.nlm.nih.gov/23528042 DMLRGX1 DI DMLRGX1 DMLRGX1 DN BAY 1082439 DMLRGX1 MI TTTHBCA DMLRGX1 MN PI3-kinase beta (PIK3CB) DMLRGX1 MT DTT DMLRGX1 MA Modulator DMLRGX1 RN Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41. DMLRGX1 RU https://www.ncbi.nlm.nih.gov/pubmed/15950434 DMYPU8V DI DMYPU8V DMYPU8V DN BAY 1238097 DMYPU8V MI TTE4BSY DMYPU8V MN Bromodomain and extraterminal domain protein (BET) DMYPU8V MT DTT DMYPU8V MA Inhibitor DMYPU8V RN Preclinical evaluation of the BET bromodomain inhibitor BAY 1238097 for the treatment of lymphoma. Br J Haematol. 2017 Sep;178(6):936-948. DMYPU8V RU https://pubmed.ncbi.nlm.nih.gov/28653353 DMF9ALP DI DMF9ALP DMF9ALP DN BAY 1817080 DMF9ALP MI TT2THBD DMF9ALP MN P2X purinoceptor 3 (P2RX3) DMF9ALP MT DTT DMF9ALP MA Antagonist DMF9ALP RN Eliapixant (BAY 1817080), a P2X3 receptor antagonist, in refractory chronic cough: a randomised, placebo-controlled, crossover phase 2a study. Eur Respir J. 2021 May 13;2004240. DMF9ALP RU https://pubmed.ncbi.nlm.nih.gov/33986030 DMQIKZG DI DMQIKZG DMQIKZG DN BAY 1834942 DMQIKZG MI TTIGH2W DMQIKZG MN Normal cross-reacting antigen (CD66c) DMQIKZG MT DTT DMQIKZG MA Blocker DMQIKZG RN ClinicalTrials.gov (NCT03596372) Study of BAY1834942 in Patients With Solid Tumors. U.S. National Institutes of Health. DMQIKZG RU https://clinicaltrials.gov/ct2/show/NCT03596372 DMNVPI1 DI DMNVPI1 DMNVPI1 DN BAY 1905254 DMNVPI1 MI TT0R2QD DMNVPI1 MN Ig-like domain-containing receptor 2 (ILDR2) DMNVPI1 MT DTT DMNVPI1 MA Inhibitor DMNVPI1 RN Characterization of BAY 1905254, an Immune Checkpoint Inhibitor Targeting the Immunoglobulin-Like Domain Containing Receptor 2 (ILDR2). Cancer Immunol Res. 2020 Jul;8(7):895-911. DMNVPI1 RU https://pubmed.ncbi.nlm.nih.gov/32312711 DMD9N12 DI DMD9N12 DMD9N12 DN BAY 2416964 DMD9N12 MI TT037IE DMD9N12 MN Aryl hydrocarbon receptor (AHR) DMD9N12 MT DTT DMD9N12 MA Antagonist DMD9N12 RN ClinicalTrials.gov (NCT04069026) A First-in-Humans Dose Finding Study for an Aryl Hydrocarbon Receptor Inhibitor (AhRi) in Patients With Advanced Cancer. U.S. National Institutes of Health. DMD9N12 RU https://clinicaltrials.gov/ct2/show/NCT04069026 DM98EP5 DI DM98EP5 DM98EP5 DN BAY 2701439 DM98EP5 MI TT6EO5L DM98EP5 MN Erbb2 tyrosine kinase receptor (HER2) DM98EP5 MT DTT DM98EP5 MA Inhibitor DM98EP5 RN National Cancer Institute Drug Dictionary (drug name BAY2701439). DM98EP5 RU https://www.cancer.gov/publications/dictionaries/cancer-drug/def/thorium-th-227-anti-her2-monoclonal-antibody-bay2701439 DM14XQN DI DM14XQN DM14XQN DN BAY 79-4620 DM14XQN MI TT2LVK8 DM14XQN MN Carbonic anhydrase IX (CA-IX) DM14XQN MT DTT DM14XQN RN Therapeutic mechanism and efficacy of the antibody-drug conjugate BAY 79-4620 targeting human carbonic anhydrase 9. Mol Cancer Ther. 2012 Feb;11(2):340-9. DM14XQN RU https://pubmed.ncbi.nlm.nih.gov/22147747 DM31RQS DI DM31RQS DM31RQS DN BAY 86-8050 DM31RQS MI TTYCILE DM31RQS MN Vasopressin receptor (VR) DM31RQS MT DTT DM31RQS MA Modulator DM31RQS RN WO patent application no. 2015,0365,63, Disubstituted trifluormethyl pyrimidinones and use thereof as ccr2 antagonists. DM31RQS RU http://worldwide.espacenet.com/publicationDetails/biblio?DB=worldwide.espacenet.com&II=0&ND=3&adjacent=true&locale=en_EP&FT=D&date=20150319&CC=WO&NR=2015036563A1&KC=A1 DMCQEL6 DI DMCQEL6 DMCQEL6 DN BAY 94-9343 DMCQEL6 MI TT4RXME DMCQEL6 MN Mesothelin (MSLN) DMCQEL6 MT DTT DMCQEL6 MA Modulator DMCQEL6 RN National Cancer Institute Drug Dictionary (drug id 712853). DMCQEL6 RU http://www.cancer.gov/publications/dictionaries/cancer-drug?cdrid=712853 DM8U3Q2 DI DM8U3Q2 DM8U3Q2 DN BAY-1075553 DM8U3Q2 MI TT9G4N0 DM8U3Q2 MN Glutamate carboxypeptidase II (GCPII) DM8U3Q2 MT DTT DM8U3Q2 MA Modulator DM8U3Q2 RN Preclinical evaluation of BAY 1075553, a novel (18)F-labelled inhibitor of prostate-specific membrane antigen for PET imaging of prostate cancer. Eur J Nucl Med Mol Imaging. 2014 Jan;41(1):89-101. DM8U3Q2 RU https://pubmed.ncbi.nlm.nih.gov/23955632 DMTB4R8 DI DMTB4R8 DMTB4R8 DN BAY1125976 DMTB4R8 MI TTAZ05C DMTB4R8 MN RAC-gamma serine/threonine-protein kinase (AKT3) DMTB4R8 MT DTT DMTB4R8 MA Modulator DMTB4R8 RN Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41. DMTB4R8 RU https://www.ncbi.nlm.nih.gov/pubmed/15950434 DMVPAZ7 DI DMVPAZ7 DMVPAZ7 DN BAY1143572 DMVPAZ7 MI TTQ7ABG DMVPAZ7 MN Positive transcription elongation factor b (P-TEFb) DMVPAZ7 MT DTT DMVPAZ7 MA Modulator DMVPAZ7 RN Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41. DMVPAZ7 RU https://www.ncbi.nlm.nih.gov/pubmed/15950434 DMUK6YM DI DMUK6YM DMUK6YM DN BAY1161909 DMUK6YM MI TTP7EGM DMUK6YM MN Dual specificity protein kinase TTK (MPS1) DMUK6YM MT DTT DMUK6YM MA Inhibitor DMUK6YM RN National Cancer Institute Drug Dictionary (drug id 761238). DMUK6YM RU http://www.cancer.gov/publications/dictionaries/cancer-drug?cdrid=761238 DM7L91K DI DM7L91K DM7L91K DN BAY1179470 DM7L91K MI TTGJVQM DM7L91K MN Fibroblast growth factor receptor 2 (FGFR2) DM7L91K MT DTT DM7L91K MA Antagonist DM7L91K RN National Cancer Institute Drug Dictionary (drug id 751593). DM7L91K RU http://www.cancer.gov/publications/dictionaries/cancer-drug?cdrid=751593 DMCJNRL DI DMCJNRL DMCJNRL DN BAY1251152 DMCJNRL MI TTQ7ABG DMCJNRL MN Positive transcription elongation factor b (P-TEFb) DMCJNRL MT DTT DMCJNRL MA Inhibitor DMCJNRL RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMCJNRL RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DMPNBJ1 DI DMPNBJ1 DMPNBJ1 DN BAY1436032 DMPNBJ1 MI TTXDKHT DMPNBJ1 MN Mutated oxalosuccinate decarboxylase (mIDH1) DMPNBJ1 MT DTT DMPNBJ1 MA Inhibitor DMPNBJ1 RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMPNBJ1 RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DMNL5G7 DI DMNL5G7 DMNL5G7 DN BAY-1817080 DMNL5G7 MI TT2THBD DMNL5G7 MN P2X purinoceptor 3 (P2RX3) DMNL5G7 MT DTT DMNL5G7 MA Inhibitor DMNL5G7 RN Antibodies and venom peptides: new modalities for ion channels. Nat Rev Drug Discov. 2019 May;18(5):339-357. DMNL5G7 RU https://pubmed.ncbi.nlm.nih.gov/30728472 DM8V62T DI DM8V62T DM8V62T DN BAY1834845 DM8V62T MI TTKFVXR DM8V62T MN Renal carcinoma antigen NY-REN-64 (IRAK-4) DM8V62T MT DTT DM8V62T MA Inhibitor DM8V62T RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DM8V62T RU http://phrma-docs.phrma.org/files/dmfile/MID_Skin_Diseases_2018_9_FINAL.pdf DML781M DI DML781M DML781M DN BAY1895344 DML781M MI TT8ZYBQ DML781M MN Serine/threonine-protein kinase ATR (FRP1) DML781M MT DTT DML781M MA Inhibitor DML781M RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DML781M RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DMRL6W5 DI DMRL6W5 DMRL6W5 DN BAY2402234 DMRL6W5 MI TTLVP78 DMRL6W5 MN Dihydroorotate dehydrogenase (DHODH) DMRL6W5 MT DTT DMRL6W5 MA Inhibitor DMRL6W5 RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMRL6W5 RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DMXIDWE DI DMXIDWE DMXIDWE DN BAY-60-5521 DMXIDWE MI TTFQAYR DMXIDWE MN Cholesteryl ester transfer protein (CETP) DMXIDWE MT DTT DMXIDWE MA Inhibitor DMXIDWE RN Single dose pharmacokinetics, pharmacodynamics, tolerability and safety of BAY 60-5521, a potent inhibitor of cholesteryl ester transfer protein. Br J Clin Pharmacol. 2012 Feb;73(2):210-8. DMXIDWE RU https://pubmed.ncbi.nlm.nih.gov/21838789 DMOUVE7 DI DMOUVE7 DMOUVE7 DN BAY-85-8102 DMOUVE7 MI TTPTXIN DMOUVE7 MN Translocator protein (TSPO) DMOUVE7 MT DTT DMOUVE7 MA Agonist DMOUVE7 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2879). DMOUVE7 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2879 DM195JA DI DM195JA DM195JA DN BAY-86-7548 DM195JA MI TTHYDUM DM195JA MN Bombesin receptor (BS) DM195JA MT DTT DM195JA MA Enhancer DM195JA RN Plasma pharmacokinetics, whole-body distribution, metabolism, and radiation dosimetry of 68Ga bombesin antagonist BAY 86-7548 in healthy men. J Nucl Med. 2013 Jun;54(6):867-72. DM195JA RU https://pubmed.ncbi.nlm.nih.gov/23564761 DMSBWAQ DI DMSBWAQ DMSBWAQ DN Bb21217 DMSBWAQ MI TTZ3P4W DMSBWAQ MN B-cell maturation protein (TNFRSF17) DMSBWAQ MT DTT DMSBWAQ MA CAR-T-Cell-Therapy DMSBWAQ RN ClinicalTrials.gov (NCT03274219) Study of bb21217 in Multiple Myeloma DMSBWAQ RU https://clinicaltrials.gov/ct2/show/NCT03274219 DMTG9WM DI DMTG9WM DMTG9WM DN BBI-6000 DMTG9WM MI TTGV6LY DMTG9WM MN Nuclear receptor ROR-gamma (RORG) DMTG9WM MT DTT DMTG9WM MA Inhibitor DMTG9WM RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMTG9WM RU http://phrma-docs.phrma.org/files/dmfile/MID_Skin_Diseases_2018_9_FINAL.pdf DM572ZL DI DM572ZL DM572ZL DN BBP-398 DM572ZL MI TT7WUAV DM572ZL MN Protein-tyrosine phosphatase SHP-2 (PTPN11) DM572ZL MT DTT DM572ZL MA Inhibitor DM572ZL RN ClinicalTrials.gov (NCT04528836) First-in-Human Study of the SHP2 Inhibitor BBP-398 in Patients With Advanced Solid Tumors. U.S. National Institutes of Health. DM572ZL RU https://clinicaltrials.gov/ct2/show/NCT04528836 DMGFABM DI DMGFABM DMGFABM DN BC-3205 DMGFABM MI TTUWYEA DMGFABM MN Bacterial 50S ribosomal RNA (Bact 50S rRNA) DMGFABM MT DTT DMGFABM MA Modulator DMGFABM RN Disk Diffusion and MIC Quality Control Ranges for BC-3205 and BC-3781, Two Novel Pleuromutilin Antibiotics. J Clin Microbiol. 2012 October; 50(10): 3361-3364. DMGFABM RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3457460/ DMM0VBU DI DMM0VBU DMM0VBU DN BCA101 DMM0VBU MI TTGKNB4 DMM0VBU MN Epidermal growth factor receptor (EGFR) DMM0VBU MT DTT DMM0VBU MA Inhibitor DMM0VBU RN ClinicalTrials.gov (NCT04429542) Study of Safety and Tolerability of BCA101 Alone and in Combination With Pembrolizumab in Patients With EGFR-driven Advanced Solid Tumors. U.S. National Institutes of Health. DMM0VBU RU https://clinicaltrials.gov/ct2/show/NCT04429542 DMM0VBU DI DMM0VBU DMM0VBU DN BCA101 DMM0VBU MI TTO3HT7 DMM0VBU MN Transforming growth factor beta (TGFB) DMM0VBU MT DTT DMM0VBU MA Inhibitor DMM0VBU RN ClinicalTrials.gov (NCT04429542) Study of Safety and Tolerability of BCA101 Alone and in Combination With Pembrolizumab in Patients With EGFR-driven Advanced Solid Tumors. U.S. National Institutes of Health. DMM0VBU RU https://clinicaltrials.gov/ct2/show/NCT04429542 DMZYCWT DI DMZYCWT DMZYCWT DN BCI-632 DMZYCWT MI TTXJ47W DMZYCWT MN Metabotropic glutamate receptor 2 (mGluR2) DMZYCWT MT DTT DMZYCWT MA Antagonist DMZYCWT RN Synthesis, in vitro pharmacology, structure-activity relationships, and pharmacokinetics of 3-alkoxy-2-amino-6-fluorobicyclo[3.1.0]hexane-2,6-dicarboxylic acid derivatives as potent and selective group II metabotropic glutamate receptor antagonists. J Med Chem. 2004 Aug 26;47(18):4570-87. DMZYCWT RU https://pubmed.ncbi.nlm.nih.gov/15317467 DMZYCWT DI DMZYCWT DMZYCWT DN BCI-632 DMZYCWT MI TT8A9EF DMZYCWT MN Metabotropic glutamate receptor 3 (mGluR3) DMZYCWT MT DTT DMZYCWT MA Modulator DMZYCWT RN Synthesis, in vitro pharmacology, structure-activity relationships, and pharmacokinetics of 3-alkoxy-2-amino-6-fluorobicyclo[3.1.0]hexane-2,6-dicarboxylic acid derivatives as potent and selective group II metabotropic glutamate receptor antagonists. J Med Chem. 2004 Aug 26;47(18):4570-87. DMZYCWT RU https://pubmed.ncbi.nlm.nih.gov/15317467 DMRXDN3 DI DMRXDN3 DMRXDN3 DN BCI-838 DMRXDN3 MI TTXJ47W DMRXDN3 MN Metabotropic glutamate receptor 2 (mGluR2) DMRXDN3 MT DTT DMRXDN3 MA Modulator DMRXDN3 RN Metabotropic glutamate receptor subtype 2 (GRM2; MGLUR2); GRM3 (MGLUR3). SciBX 3(13); doi:10.1038/scibx.2010.413. April 1 2010 DMRXDN3 RU http://www.nature.com/scibx/journal/v3/n13/full/scibx.2010.413.html DMRXDN3 DI DMRXDN3 DMRXDN3 DN BCI-838 DMRXDN3 MI TT8A9EF DMRXDN3 MN Metabotropic glutamate receptor 3 (mGluR3) DMRXDN3 MT DTT DMRXDN3 MA Modulator DMRXDN3 RN Metabotropic glutamate receptor subtype 2 (GRM2; MGLUR2); GRM3 (MGLUR3). SciBX 3(13); doi:10.1038/scibx.2010.413. April 1 2010 DMRXDN3 RU http://www.nature.com/scibx/journal/v3/n13/full/scibx.2010.413.html DMQ76B4 DI DMQ76B4 DMQ76B4 DN BCL11a shRNA DMQ76B4 MI TTPLHYK DMQ76B4 MN BCL11A messenger RNA (BCL11A mRNA) DMQ76B4 MT DTT DMQ76B4 MA Inhibitor DMQ76B4 RN Clinical pipeline report, company report or official report of bluebird bio. DMQ76B4 RU https://www.bluebirdbio.com/our-science/pipeline DMZ51EX DI DMZ51EX DMZ51EX DN BCL201 DMZ51EX MI TTJGNVC DMZ51EX MN Apoptosis regulator Bcl-2 (BCL-2) DMZ51EX MT DTT DMZ51EX MA Inhibitor DMZ51EX RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMZ51EX RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DMJ37LH DI DMJ37LH DMJ37LH DN BCMA CART DMJ37LH MI TTZ3P4W DMJ37LH MN B-cell maturation protein (TNFRSF17) DMJ37LH MT DTT DMJ37LH MA CAR-T-Cell-Therapy DMJ37LH RN ClinicalTrials.gov (NCT03549442) Up-front CART-BCMA With or Without huCART19 in High-risk Multiple Myeloma DMJ37LH RU https://clinicaltrials.gov/ct2/show/NCT03549442 DM2V4EO DI DM2V4EO DM2V4EO DN BCMA CART and huCART19 DM2V4EO MI TTZ3P4W DM2V4EO MN B-cell maturation protein (TNFRSF17) DM2V4EO MT DTT DM2V4EO MA CAR-T-Cell-Therapy(Dual specific) DM2V4EO RN ClinicalTrials.gov (NCT03549442) Up-front CART-BCMA With or Without huCART19 in High-risk Multiple Myeloma DM2V4EO RU https://clinicaltrials.gov/ct2/show/NCT03549442 DM2V4EO DI DM2V4EO DM2V4EO DN BCMA CART and huCART19 DM2V4EO MI TTW640A DM2V4EO MN B-lymphocyte surface antigen B4 (CD19) DM2V4EO MT DTT DM2V4EO MA CAR-T-Cell-Therapy(Dual specific) DM2V4EO RN ClinicalTrials.gov (NCT03549442) Up-front CART-BCMA With or Without huCART19 in High-risk Multiple Myeloma DM2V4EO RU https://clinicaltrials.gov/ct2/show/NCT03549442 DMJ4W5V DI DMJ4W5V DMJ4W5V DN BCMA CAR-T Cells DMJ4W5V MI TTZ3P4W DMJ4W5V MN B-cell maturation protein (TNFRSF17) DMJ4W5V MT DTT DMJ4W5V MA CAR-T-Cell-Therapy DMJ4W5V RN ClinicalTrials.gov (NCT03661554) BCMA Nano Antibody CAR-T Cells for Patients With Refractory and Relapsed Multiple Myeloma DMJ4W5V RU https://clinicaltrials.gov/ct2/show/NCT03661554 DMZDLHV DI DMZDLHV DMZDLHV DN BCMA nanobody CAR-T cells DMZDLHV MI TTZ3P4W DMZDLHV MN B-cell maturation protein (TNFRSF17) DMZDLHV MT DTT DMZDLHV MA CAR-T-Cell-Therapy DMZDLHV RN ClinicalTrials.gov (NCT03664661) BCMA-CAR-T in Relapsed/Refractory Multiple Myeloma DMZDLHV RU https://clinicaltrials.gov/ct2/show/NCT03664661 DMZ13WQ DI DMZ13WQ DMZ13WQ DN BCMA-CD19 cCAR DMZ13WQ MI TTZ3P4W DMZ13WQ MN B-cell maturation protein (TNFRSF17) DMZ13WQ MT DTT DMZ13WQ RN Clinical pipeline report, company report or official report of iCell Gene Therapeutics. DMZ13WQ RU https://icellgene.com/our-pipeline.html DMZ13WQ DI DMZ13WQ DMZ13WQ DN BCMA-CD19 cCAR DMZ13WQ MI TTW640A DMZ13WQ MN B-lymphocyte surface antigen B4 (CD19) DMZ13WQ MT DTT DMZ13WQ RN Clinical pipeline report, company report or official report of iCell Gene Therapeutics. DMZ13WQ RU https://icellgene.com/our-pipeline.html DMEPHMR DI DMEPHMR DMEPHMR DN BCMA-CS1 cCAR DMEPHMR MI TTZ3P4W DMEPHMR MN B-cell maturation protein (TNFRSF17) DMEPHMR MT DTT DMEPHMR RN ClinicalTrials.gov (NCT04156269) BCMA-CS1 Compound CAR (cCAR) T Cells for Relapsed/Refractory Multiple Myeloma. U.S. National Institutes of Health. DMEPHMR RU https://clinicaltrials.gov/ct2/show/NCT04156269 DMEPHMR DI DMEPHMR DMEPHMR DN BCMA-CS1 cCAR DMEPHMR MI TT7ILZ1 DMEPHMR MN SLAM family member 7 SLAMF7 (CS1) DMEPHMR MT DTT DMEPHMR RN ClinicalTrials.gov (NCT04156269) BCMA-CS1 Compound CAR (cCAR) T Cells for Relapsed/Refractory Multiple Myeloma. U.S. National Institutes of Health. DMEPHMR RU https://clinicaltrials.gov/ct2/show/NCT04156269 DMW0ZDF DI DMW0ZDF DMW0ZDF DN BCMA-specific CAR-expressing T Lymphocytes DMW0ZDF MI TTZ3P4W DMW0ZDF MN B-cell maturation protein (TNFRSF17) DMW0ZDF MT DTT DMW0ZDF MA CAR-T-Cell-Therapy DMW0ZDF RN ClinicalTrials.gov (NCT03502577) BCMA-Specific CAR T-Cells Combined With a Gamma Secretase Inhibitor (LY3039478) to Treat Relapsed or Persistent Multiple Myeloma DMW0ZDF RU https://clinicaltrials.gov/ct2/show/NCT03502577 DMGAP53 DI DMGAP53 DMGAP53 DN BDD-10103 DMGAP53 MI TTRK8B9 DMGAP53 MN Sodium channel unspecific (NaC) DMGAP53 MT DTT DMGAP53 MA Modulator DMGAP53 RN Clinical pipeline report, company report or official report of Birds Pharma AG. DMGAP53 RU http://www.birdspharma.com/projects/bdd_10103/ DMUR49N DI DMUR49N DMUR49N DN Begacestat DMUR49N MI TT9W8GU DMUR49N MN Gamma-secretase (GS) DMUR49N MT DTT DMUR49N MA Modulator DMUR49N RN Begacestat (GSI-953): a novel, selective thiophene sulfonamide inhibitor of amyloid precursor protein gamma-secretase for the treatment of Alzheimer's disease. J Pharmacol Exp Ther. 2009 Nov;331(2):598-608. DMUR49N RU https://pubmed.ncbi.nlm.nih.gov/19671883 DM9R0VA DI DM9R0VA DM9R0VA DN Belerofon DM9R0VA MI TTSYFMA DM9R0VA MN Interferon alpha/beta receptor 1 (IFNAR1) DM9R0VA MT DTT DM9R0VA MA Modulator DM9R0VA RN WO patent application no. 2009,0153,36, Controlled release interferon drug products and treatment of hcv infection using same. DM9R0VA RU http://worldwide.espacenet.com/publicationDetails/biblio?DB=worldwide.espacenet.com&II=0&ND=3&adjacent=true&locale=en_EP&FT=D&date=20090129&CC=WO&NR=2009015336A2&KC=A2 DM0ZNAR DI DM0ZNAR DM0ZNAR DN Belvarafenib DM0ZNAR MI TTB18GJ DM0ZNAR MN Proto-oncogene c-RAF (c-RAF) DM0ZNAR MT DTT DM0ZNAR MA Inhibitor DM0ZNAR RN Clinical pipeline report, company report or official report of Hanmi Pharmaceutical. DM0ZNAR RU https://www.hanmipharm.com/ehanmi/handler/Rnd-Pipeline DMN7J43 DI DMN7J43 DMN7J43 DN Benzo(a)pyrene DMN7J43 MI DTI7UX6 DMN7J43 MN Breast cancer resistance protein (ABCG2) DMN7J43 MT DTP DMN7J43 MA Substrate DMN7J43 RN A prediction model of substrates and non-substrates of breast cancer resistance protein (BCRP) developed by GA-CG-SVM method. Comput Biol Med. 2011 Nov;41(11):1006-13. DMN7J43 RU https://doi.org/10.1016/j.compbiomed.2011.08.009 DMMW4HV DI DMMW4HV DMMW4HV DN Benzoylphenylurea DMMW4HV MI DTI7UX6 DMMW4HV MN Breast cancer resistance protein (ABCG2) DMMW4HV MT DTP DMMW4HV MA Substrate DMMW4HV RN American Association for Cancer Research. DMMW4HV RU http://www.aacrmeetingabstracts.org/cgi/content/abstract/2004/1/119-b DMBUI2A DI DMBUI2A DMBUI2A DN BETULINIC ACID DMBUI2A MI TTIU7X1 DMBUI2A MN Herpes simplex virus DNA polymerase UL30 (HSV UL30) DMBUI2A MT DTT DMBUI2A MA Inhibitor DMBUI2A RN DNA polymerase beta inhibitors from Tetracera boiviniana. J Nat Prod. 1999 Dec;62(12):1660-3. DMBUI2A RU https://pubmed.ncbi.nlm.nih.gov/10654414 DM7RPSG DI DM7RPSG DM7RPSG DN BF-1 DM7RPSG MI TT85JO3 DM7RPSG MN 5-HT receptor (5HTR) DM7RPSG MT DTT DM7RPSG MA Modulator DM7RPSG RN Serotonin (5-HT2B) receptor. SciBX 4(19); doi:10.1038/scibx.2011.534. May 12 2011 DM7RPSG RU http://www.nature.com/scibx/journal/v4/n19/full/scibx.2011.534.html DMHELFU DI DMHELFU DMHELFU DN BF-389 DMHELFU MI TT2J34L DMHELFU MN Arachidonate 5-lipoxygenase (5-LOX) DMHELFU MT DTT DMHELFU MA Modulator DMHELFU RN Antiarthritic profile of BF-389--a novel anti-inflammatory agent with low ulcerogenic liability. Agents Actions. 1992 Sep;37(1-2):90-8. DMHELFU RU https://pubmed.ncbi.nlm.nih.gov/1456184 DM84LXE DI DM84LXE DM84LXE DN BGB-10188 DM84LXE MI TTGBPJE DM84LXE MN PI3-kinase delta (PIK3CD) DM84LXE MT DTT DM84LXE MA Inhibitor DM84LXE RN ClinicalTrials.gov (NCT04282018) Brief Title: Study of BGB-10188 as Monotherapy, and in Combination With Zanubrutinib, and Tislelizumab. U.S. National Institutes of Health. DM84LXE RU https://clinicaltrials.gov/ct2/show/NCT04282018 DM7QTIC DI DM7QTIC DM7QTIC DN BGB-11417 DM7QTIC MI TTJGNVC DM7QTIC MN Apoptosis regulator Bcl-2 (BCL-2) DM7QTIC MT DTT DM7QTIC MA Inhibitor DM7QTIC RN Clinical pipeline report, company report or official report of BeiGene. DM7QTIC RU https://www.beigenemedical.com/CongressDocuments/Hu%20BGB-11417%20AACR%20Poster%202020.pdf DMUP6M5 DI DMUP6M5 DMUP6M5 DN BGB-15025 DMUP6M5 MI TTSHWUP DMUP6M5 MN MEK kinase kinase 1 (MAP4K1) DMUP6M5 MT DTT DMUP6M5 MA Inhibitor DMUP6M5 RN ClinicalTrials.gov (NCT04649385) BGB-15025 Alone and in Combination With Anti-PD-1 Monoclonal Antibody Tislelizumab in Participants With Advanced Solid Tumors. U.S. National Institutes of Health. DMUP6M5 RU https://clinicaltrials.gov/ct2/show/NCT04649385 DMIF9DZ DI DMIF9DZ DMIF9DZ DN BGB-3113 DMIF9DZ MI TTGM6VW DMIF9DZ MN Tyrosine-protein kinase BTK (ATK) DMIF9DZ MT DTT DMIF9DZ MA Inhibitor DMIF9DZ RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMIF9DZ RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DMQMEDH DI DMQMEDH DMQMEDH DN BGB-A445 DMQMEDH MI TTL31H0 DMQMEDH MN OX40L receptor (CD134) DMQMEDH MT DTT DMQMEDH RN Clinical pipeline report, company report or official report of BeiGene. DMQMEDH RU https://www.beigene.com/science-and-product-portfolio/pipeline DMED4AJ DI DMED4AJ DMED4AJ DN BGC-20-1259 DMED4AJ MI TT3ROYC DMED4AJ MN Serotonin transporter (SERT) DMED4AJ MT DTT DMED4AJ MA Modulator DMED4AJ RN Bifeprunox: a partial agonist at dopamine D2 and serotonin 1A receptors, influences nicotine-seeking behaviour in response to drug-associated stimuli in rats.Addict Biol.2012 Mar;17(2):274-86. DMED4AJ RU https://www.ncbi.nlm.nih.gov/pubmed/21521422 DMM2EZW DI DMM2EZW DMM2EZW DN BHV-5000 DMM2EZW MI TT9IK2Z DMM2EZW MN N-methyl-D-aspartate receptor (NMDAR) DMM2EZW MT DTT DMM2EZW MA Antagonist DMM2EZW RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMM2EZW RU http://phrma-docs.phrma.org/files/dmfile/MID_Neurological-Disorders-Drug-List_2018.pdf DMUJ1EL DI DMUJ1EL DMUJ1EL DN BI 113823 DMUJ1EL MI TTG5QIA DMUJ1EL MN B1 bradykinin receptor (BDKRB1) DMUJ1EL MT DTT DMUJ1EL MA Modulator DMUJ1EL RN The bradykinin B1 receptor antagonist BI113823 reverses inflammatory hyperalgesia by desensitization of peripheral and spinal neurons. Eur J Pain. 2015 Jan;19(1):132-42. DMUJ1EL RU https://pubmed.ncbi.nlm.nih.gov/25088373 DMGMFXJ DI DMGMFXJ DMGMFXJ DN BI 1701963 DMGMFXJ MI TTB1RA4 DMGMFXJ MN GTPase KRas (KRAS) DMGMFXJ MT DTT DMGMFXJ MA Inhibitor DMGMFXJ RN Clinical pipeline report, company report or official report of Boehringer Ingelheim. DMGMFXJ RU https://www.boehringer-ingelheim.com/press-release/first-pan-kras-inhibitor-advances-clinical-testing DMFJGUL DI DMFJGUL DMFJGUL DN BI 3011441 DMFJGUL MI TTZCRP3 DMFJGUL MN ERK activator kinase (MEK) DMFJGUL MT DTT DMFJGUL MA Inhibitor DMFJGUL RN Clinical pipeline report, company report or official report of Boehringer Ingelheim. DMFJGUL RU https://www.inoncology.com/ourpipeline/mek-inhibitor DMWHZFS DI DMWHZFS DMWHZFS DN BI 754091 DMWHZFS MI TTNBFWK DMWHZFS MN Programmed cell death protein 1 (PD-1) DMWHZFS MT DTT DMWHZFS MA Inhibitor DMWHZFS RN Clinical pipeline report, company report or official report of Boehringer Ingelheim. DMWHZFS RU https://www.inoncology.com/ourpipeline/pd1-inhibitor DMZMAOW DI DMZMAOW DMZMAOW DN BI 765063 DMZMAOW MI TTBRJS9 DMZMAOW MN Inhibitory receptor SHPS-1 (SIRPA) DMZMAOW MT DTT DMZMAOW MA Antagonist DMZMAOW RN Clinical pipeline report, company report or official report of OSE Immunotherapeutics. DMZMAOW RU https://ose-immuno.com/en/ose-product/ose-172/ DMRI6YT DI DMRI6YT DMRI6YT DN BI 836880 DMRI6YT MI TTKLQTJ DMRI6YT MN Angiopoietin-2 (ANGPT2) DMRI6YT MT DTT DMRI6YT MA Blocker DMRI6YT RN Clinical pipeline report, company report or official report of Boehringer Ingelheim. DMRI6YT RU https://www.inoncology.com/ourpipeline/vegf-ang2-inhibitor DMRI6YT DI DMRI6YT DMRI6YT DN BI 836880 DMRI6YT MI TT9HKJA DMRI6YT MN Vascular endothelial growth factor (VEGF) DMRI6YT MT DTT DMRI6YT MA Blocker DMRI6YT RN Clinical pipeline report, company report or official report of Boehringer Ingelheim. DMRI6YT RU https://www.inoncology.com/ourpipeline/vegf-ang2-inhibitor DMMQ12N DI DMMQ12N DMMQ12N DN BI 860585 DMMQ12N MI TTCJG29 DMMQ12N MN Serine/threonine-protein kinase mTOR (mTOR) DMMQ12N MT DTT DMMQ12N MA Inhibitor DMMQ12N RN Clinical pipeline report, company report or official report of tatcongress. DMMQ12N RU http://tatcongress.org/wp-content/uploads/2014/05/tat2014-abstracts-poster-session-6_140217.pdf DM7W5N2 DI DM7W5N2 DM7W5N2 DN BI 894999 DM7W5N2 MI TTE4BSY DM7W5N2 MN Bromodomain and extraterminal domain protein (BET) DM7W5N2 MT DTT DM7W5N2 MA Inhibitor DM7W5N2 RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DM7W5N2 RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DMEPJ7C DI DMEPJ7C DMEPJ7C DN BI 905677 DMEPJ7C MI TTSXOWE DMEPJ7C MN LDL receptor related protein-6 (LRP-6) DMEPJ7C MT DTT DMEPJ7C MA Antagonist DMEPJ7C RN Clinical pipeline report, company report or official report of Boehringer Ingelheim. DMEPJ7C RU https://www.inoncology.com/ourpipeline/lrp56-antagonist DMEPJ7C DI DMEPJ7C DMEPJ7C DN BI 905677 DMEPJ7C MI TT7VMG4 DMEPJ7C MN Low-density lipoprotein receptor-related protein 5 (LRP5) DMEPJ7C MT DTT DMEPJ7C MA Antagonist DMEPJ7C RN Clinical pipeline report, company report or official report of Boehringer Ingelheim. DMEPJ7C RU https://www.inoncology.com/ourpipeline/lrp56-antagonist DMXO3PV DI DMXO3PV DMXO3PV DN BI 905681 DMXO3PV MI TT7VMG4 DMXO3PV MN Low-density lipoprotein receptor-related protein 5 (LRP5) DMXO3PV MT DTT DMXO3PV MA Antagonist DMXO3PV RN Clinical pipeline report, company report or official report of Boehringer Ingelheim. DMXO3PV RU https://www.inoncology.com/ourpipeline/lrp56-antagonist DME9NYV DI DME9NYV DME9NYV DN BI 905711 DME9NYV MI TTW20TU DME9NYV MN TRAIL receptor 2 (TRAIL-R2) DME9NYV MT DTT DME9NYV MA Activator DME9NYV RN Selective Tumor Cell Apoptosis and Tumor Regression in CDH17-Positive Colorectal Cancer Models using BI 905711, a Novel Liver-Sparing TRAILR2 Agonist. Mol Cancer Ther. 2021 Jan;20(1):96-108. DME9NYV RU https://pubmed.ncbi.nlm.nih.gov/33037135 DM2Z4YQ DI DM2Z4YQ DM2Z4YQ DN BI 907828 DM2Z4YQ MI TT08GJW DM2Z4YQ MN Ubiquitin-protein ligase E3 Mdm2 (MDM2) DM2Z4YQ MT DTT DM2Z4YQ MA Inhibitor DM2Z4YQ RN MDM2 inhibition: an important step forward in cancer therapy. Leukemia. 2020 Nov;34(11):2858-2874. DM2Z4YQ RU https://pubmed.ncbi.nlm.nih.gov/32651541 DMKQHE5 DI DMKQHE5 DMKQHE5 DN BI-11634 DMKQHE5 MI TTCIHJA DMKQHE5 MN Coagulation factor Xa (F10) DMKQHE5 MT DTT DMKQHE5 MA Inhibitor DMKQHE5 RN Semuloparin for the prevention of venous thromboembolic events in cancer patients. Drugs Today (Barc). 2012 Jul;48(7):451-7. DMKQHE5 RU https://pubmed.ncbi.nlm.nih.gov/22844656 DMLJOAF DI DMLJOAF DMLJOAF DN BI-135585 DMLJOAF MI TTN7BL9 DMLJOAF MN Corticosteroid 11-beta-dehydrogenase 1 (HSD11B1) DMLJOAF MT DTT DMLJOAF MA Modulator DMLJOAF RN New Therapeutic Strategies for Type 2 Diabetes: Small Molecule Approaches. 2012. Chapter 5. Page(131). DMLJOAF RU https://books.google.com.hk/books?id=0rmlVGhlJ0IC&pg=PA131&lpg=PA131&dq=RG-7234++New+Therapeutic+Strategies+for+Type+2+Diabetes&source=bl&ots=toqK7w4uiI&sig=sx5iyfQWH2bTCSZmT5aUQiKfPuM&hl=zh-CN&sa=X&ved=0CB0Q6AEwAGoVChMIsZ_k6dDGyAIViLeOCh0oUQpr#v=onepage&q=RG-7234%20%20New%20Therapeutic%20Strategies%20for%20Type%202%20Diabetes&f=false DM2KVM0 DI DM2KVM0 DM2KVM0 DN BI-44847 DM2KVM0 MI TTLWPVF DM2KVM0 MN Sodium/glucose cotransporter 2 (SGLT2) DM2KVM0 MT DTT DM2KVM0 MA Modulator DM2KVM0 RN Clinical potential of sodium-glucose cotransporter 2 inhibitors in the management of type 2 diabetes DM2KVM0 RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3437808 DM3JOIX DI DM3JOIX DM3JOIX DN BI-754091 DM3JOIX MI TTNBFWK DM3JOIX MN Programmed cell death protein 1 (PD-1) DM3JOIX MT DTT DM3JOIX RN Development of Inhibitors of the Programmed Cell Death-1/Programmed Cell Death-Ligand 1 Signaling Pathway.J Med Chem. 2019 Feb 28;62(4):1715-1730. DM3JOIX RU https://pubmed.ncbi.nlm.nih.gov/30247903 DMNUY32 DI DMNUY32 DMNUY32 DN BI-811283 DMNUY32 MI TT5LS6T DMNUY32 MN Aurora kinase B (AURKB) DMNUY32 MT DTT DMNUY32 MA Inhibitor DMNUY32 RN Aurora kinase inhibitors: progress towards the clinic. Invest New Drugs. 2012 Dec;30(6):2411-32. DMNUY32 RU https://pubmed.ncbi.nlm.nih.gov/22350019 DMOJZUE DI DMOJZUE DMOJZUE DN BI-831266 DMOJZUE MI TT5LS6T DMOJZUE MN Aurora kinase B (AURKB) DMOJZUE MT DTT DMOJZUE MA Modulator DMOJZUE RN A phase 1 dose escalation study of BI 831266, an inhibitor of Aurora kinase B, in patients with advanced solid tumors. Invest New Drugs. 2015 Apr;33(2):409-22. DMOJZUE RU https://pubmed.ncbi.nlm.nih.gov/25529193 DM4T916 DI DM4T916 DM4T916 DN BI-836845 DM4T916 MI TTT6LOU DM4T916 MN Insulin-like growth factor-I (IGF1) DM4T916 MT DTT DM4T916 MA Modulator DM4T916 RN Pharmacodynamic and antineoplastic activity of BI 836845, a fully human IGF ligand-neutralizing antibody, and mechanistic rationale for combination with rapamycin.Mol Cancer Ther.2014 Feb;13(2):399-409. DM4T916 RU https://www.ncbi.nlm.nih.gov/pubmed/24296829 DMGFH7T DI DMGFH7T DMGFH7T DN BI-836880 DMGFH7T MI TT9HKJA DMGFH7T MN Vascular endothelial growth factor (VEGF) DMGFH7T MT DTT DMGFH7T MA Inhibitor DMGFH7T RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMGFH7T RU http://phrma-docs.phrma.org/files/dmfile/MID_Immuno-Oncology-2017_Drug-List1.pdf DMY4B6J DI DMY4B6J DMY4B6J DN BI-847325 DMY4B6J MI TT5LS6T DMY4B6J MN Aurora kinase B (AURKB) DMY4B6J MT DTT DMY4B6J MA Modulator DMY4B6J RN doi: 10.1158/1535-7163.TARG-13-B281 DMY4B6J RU http://mct.aacrjournals.org/content/12/11_Supplement/B281.short DMY4B6J DI DMY4B6J DMY4B6J DN BI-847325 DMY4B6J MI TTROQ37 DMY4B6J MN MAPK/ERK kinase kinase (MAP3K) DMY4B6J MT DTT DMY4B6J MA Modulator DMY4B6J RN doi: 10.1158/1535-7163.TARG-13-B281 DMY4B6J RU http://mct.aacrjournals.org/content/12/11_Supplement/B281.short DMNOSYW DI DMNOSYW DMNOSYW DN BI-853520 DMNOSYW MI TTON5IT DMNOSYW MN Focal adhesion kinase 1 (FAK) DMNOSYW MT DTT DMNOSYW MA Modulator DMNOSYW RN Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41. DMNOSYW RU https://www.ncbi.nlm.nih.gov/pubmed/15950434 DMP70FI DI DMP70FI DMP70FI DN BIBT986 DMP70FI MI TTCIHJA DMP70FI MN Coagulation factor Xa (F10) DMP70FI MT DTT DMP70FI MA Inhibitor DMP70FI RN Pharmacokinetics and pharmacodynamics of BIBT 986, a novel small molecule dual inhibitor of thrombin and factor Xa. J Thromb Haemost. 2006 Jul;4(7):1502-9. DMP70FI RU https://pubmed.ncbi.nlm.nih.gov/16839346 DMUBMN5 DI DMUBMN5 DMUBMN5 DN BIBV 308 DMUBMN5 MI TT2O84V DMUBMN5 MN Thromboxane A2 receptor (TBXA2R) DMUBMN5 MT DTT DMUBMN5 MA Antagonist DMUBMN5 RN AT-1 receptor antagonism modifies the mediation of endothelin-1, thromboxane A2, and catecholamines in the renal constrictor response to angiotensin II. Kidney Int Suppl. 2005 Jan;(93):S3-9. DMUBMN5 RU https://pubmed.ncbi.nlm.nih.gov/15613065 DM79XGM DI DM79XGM DM79XGM DN BIBX-1382 DM79XGM MI TTGKNB4 DM79XGM MN Epidermal growth factor receptor (EGFR) DM79XGM MT DTT DM79XGM MA Antagonist DM79XGM RN Phase I and pharmacokinetic study of BIBX 1382 BS, an epidermal growth factor receptor (EGFR) inhibitor, given in a continuous daily oral administration. Eur J Cancer. 2002 May;38(8):1072-80. DM79XGM RU https://pubmed.ncbi.nlm.nih.gov/12008195 DM5AW7J DI DM5AW7J DM5AW7J DN BIIB 015 DM5AW7J MI TTN7HMG DM5AW7J MN Teratocarcinoma-derived growth factor 1 (TDGF1) DM5AW7J MT DTT DM5AW7J RN An antibody-cytotoxic conjugate, BIIB015, is a new targeted therapy for Cripto positive tumours. Eur J Cancer. 2011 Jul;47(11):1736-46. DM5AW7J RU https://pubmed.ncbi.nlm.nih.gov/21458984 DMZ1V0E DI DMZ1V0E DMZ1V0E DN BIIB 022 DMZ1V0E MI TTHRID2 DMZ1V0E MN Insulin-like growth factor I receptor (IGF1R) DMZ1V0E MT DTT DMZ1V0E MA Antagonist DMZ1V0E RN A phase 1, open-label, dose-escalation study of BIIB022 (anti-IGF-1R monoclonal antibody) in subjects with relapsed or refractory solid tumors. Invest New Drugs. 2014 Jun;32(3):518-25. DMZ1V0E RU https://pubmed.ncbi.nlm.nih.gov/24458261 DMTRF71 DI DMTRF71 DMTRF71 DN BIIB 028 DMTRF71 MI TT78R5H DMTRF71 MN Heat shock protein 90 alpha (HSP90A) DMTRF71 MT DTT DMTRF71 MA Inhibitor DMTRF71 RN Phase I study of BIIB028, a selective heat shock protein 90 inhibitor, in patients with refractory metastatic or locally advanced solid tumors. Clin Cancer Res. 2013 Sep 1;19(17):4824-31. DMTRF71 RU https://pubmed.ncbi.nlm.nih.gov/23873691 DMVS87W DI DMVS87W DMVS87W DN BIIB068 DMVS87W MI TTGM6VW DMVS87W MN Tyrosine-protein kinase BTK (ATK) DMVS87W MT DTT DMVS87W MA Inhibitor DMVS87W RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMVS87W RU http://phrma-docs.phrma.org/files/dmfile/medicines-in-development-drug-list-autoimmune-diseases.pdf DMUC6EP DI DMUC6EP DMUC6EP DN BIIB095 DMUC6EP MI TT4G2JS DMUC6EP MN Voltage-gated sodium channel alpha Nav1.7 (SCN9A) DMUC6EP MT DTT DMUC6EP MA Inhibitor DMUC6EP RN Antibodies and venom peptides: new modalities for ion channels. Nat Rev Drug Discov. 2019 May;18(5):339-357. DMUC6EP RU https://pubmed.ncbi.nlm.nih.gov/30728472 DM9UZD7 DI DM9UZD7 DM9UZD7 DN Bile acid DM9UZD7 MI DEDZRQ1 DM9UZD7 MN Cytochrome P450 7A1 (CYP7A1) DM9UZD7 MT DME DM9UZD7 MA Metabolism DM9UZD7 RN FGF15 activates Hippo signaling to suppress bile acid metabolism and liver tumorigenesis. Dev Cell. 2019 Feb 25;48(4):460-474.e9. DM9UZD7 RU https://pubmed.ncbi.nlm.nih.gov/30745141 DMBTSZD DI DMBTSZD DMBTSZD DN BIMU-1 DMBTSZD MI TTNXLKE DMBTSZD MN 5-HT 3 receptor (5HT3R) DMBTSZD MT DTT DMBTSZD MA Modulator DMBTSZD RN Gastroprokinetic properties of the benzimidazolone derivative BIMU 1, an agonist at 5-hydroxytryptamine4 and antagonist at 5-hydroxytryptamine3 receptors. Naunyn Schmiedebergs Arch Pharmacol. 1994 Apr;349(4):338-45. DMBTSZD RU https://pubmed.ncbi.nlm.nih.gov/8058105 DMBTSZD DI DMBTSZD DMBTSZD DN BIMU-1 DMBTSZD MI TT07C3Y DMBTSZD MN 5-HT 4 receptor (HTR4) DMBTSZD MT DTT DMBTSZD MA Modulator DMBTSZD RN Gastroprokinetic properties of the benzimidazolone derivative BIMU 1, an agonist at 5-hydroxytryptamine4 and antagonist at 5-hydroxytryptamine3 receptors. Naunyn Schmiedebergs Arch Pharmacol. 1994 Apr;349(4):338-45. DMBTSZD RU https://pubmed.ncbi.nlm.nih.gov/8058105 DMQ9KZW DI DMQ9KZW DMQ9KZW DN Biomed 101 DMQ9KZW MI TTN53ZF DMQ9KZW MN Leukotriene B4 receptor 1 (LTB4R) DMQ9KZW MT DTT DMQ9KZW MA Binder DMQ9KZW RN Biomed 101, a leukotriene B4 inhibitor, may decrease IL-2 toxicity. 2003 ASCO Annual Meeting. 2003. DMQ9KZW RU http://www.asco.org/ASCOv2/Meetings/Abstracts?&vmview=abst_detail_view&confID=23&abstractID=101740 DMQ9KZW DI DMQ9KZW DMQ9KZW DN Biomed 101 DMQ9KZW MI TTVJX54 DMQ9KZW MN Leukotriene B4 receptor 2 (LTB4R2) DMQ9KZW MT DTT DMQ9KZW MA Inhibitor DMQ9KZW RN Diaryl ether/carboxylic acid derivatives of LY255283: Receptor antagonists of leukotriene B4, Bioorg. Med. Chem. Lett. 3(10):1985-1990 (1993). DMQ9KZW RU http://www.sciencedirect.com/science/article/pii/S0960894X01810003 DMS4P6K DI DMS4P6K DMS4P6K DN Biostrophin DMS4P6K MI TT48MP6 DMS4P6K MN Dystrophin (DMD) DMS4P6K MT DTT DMS4P6K MA Modulator DMS4P6K RN Therapy for Duchenne muscular dystrophy: renewed optimism from genetic approaches. Nat Rev Genet. 2013 Jun;14(6):373-8. DMS4P6K RU https://pubmed.ncbi.nlm.nih.gov/23609411 DMGAR9Y DI DMGAR9Y DMGAR9Y DN BIT225 DMGAR9Y MI TT5FNQT DMGAR9Y MN Human immunodeficiency virus Protease (HIV PR) DMGAR9Y MT DTT DMGAR9Y MA Inhibitor DMGAR9Y RN 2011 Pipeline of Biotron. DMGAR9Y RU http://www.biotron.com.au/ DM61JH5 DI DM61JH5 DM61JH5 DN BIWA 4 DM61JH5 MI TTWFBT7 DM61JH5 MN Extracellular matrix receptor III (CD44) DM61JH5 MT DTT DM61JH5 RN A phase I dose escalation study with anti-CD44v6 bivatuzumab mertansine in patients with incurable squamous cell carcinoma of the head and neck or esophagus. Clin Cancer Res. 2006 Oct 15;12(20 Pt 1):6064-72. DM61JH5 RU https://pubmed.ncbi.nlm.nih.gov/17062682 DMX9ER7 DI DMX9ER7 DMX9ER7 DN BIZELESIN DMX9ER7 MI TTUTN1I DMX9ER7 MN Human Deoxyribonucleic acid (hDNA) DMX9ER7 MT DTT DMX9ER7 MA Inhibitor DMX9ER7 RN Mapping of DNA alkylation sites induced by adozelesin and bizelesin in human cells by ligation-mediated polymerase chain reaction. Biochemistry. 1994 May 17;33(19):6024-30. DMX9ER7 RU https://pubmed.ncbi.nlm.nih.gov/8180230 DMAYSFK DI DMAYSFK DMAYSFK DN BL-1021 DMAYSFK MI TTAWNKZ DMAYSFK MN Norepinephrine transporter (NET) DMAYSFK MT DTT DMAYSFK MA Modulator DMAYSFK RN Company report (BioLineRx) DMAYSFK RU http://www.biolinerx.com/default.asp?pageid=13&itemid=13 DMAYSFK DI DMAYSFK DMAYSFK DN BL-1021 DMAYSFK MI TT3ROYC DMAYSFK MN Serotonin transporter (SERT) DMAYSFK MT DTT DMAYSFK MA Modulator DMAYSFK RN Company report (BioLineRx) DMAYSFK RU http://www.biolinerx.com/default.asp?pageid=13&itemid=13 DM27J3D DI DM27J3D DM27J3D DN BLU-554 DM27J3D MI TT1KX2S DM27J3D MN FGFR4 messenger RNA (FGFR4 mRNA) DM27J3D MT DTT DM27J3D MA Inhibitor DM27J3D RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DM27J3D RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DMYHNV3 DI DMYHNV3 DMYHNV3 DN BLY719 DMYHNV3 MI TTEUNMR DMYHNV3 MN PI3-kinase alpha (PIK3CA) DMYHNV3 MT DTT DMYHNV3 MA Inhibitor DMYHNV3 RN In vitro anticancer activity of PI3K alpha selective inhibitor BYL719 in head and neck cancer. Anticancer Res. 2015 Jan;35(1):175-82. DMYHNV3 RU https://pubmed.ncbi.nlm.nih.gov/25550549 DMIRX3Z DI DMIRX3Z DMIRX3Z DN BM-212 DMIRX3Z MI TTTLB3R DMIRX3Z MN Mycobacterium Membrane protein mmpL3 (MycB mmpL3) DMIRX3Z MT DTT DMIRX3Z MA Modulator DMIRX3Z RN MmpL3 is the cellular target of the antitubercular pyrrole derivative BM212. Antimicrob Agents Chemother. 2012 Jan;56(1):324-31. DMIRX3Z RU https://pubmed.ncbi.nlm.nih.gov/22024828 DM43RV5 DI DM43RV5 DM43RV5 DN BM-ca DM43RV5 MI TTUE541 DM43RV5 MN Leukocyte surface antigen Leu-16 (CD20) DM43RV5 MT DTT DM43RV5 RN BM-ca is a newly defined type I/II anti-CD20 monoclonal antibody with unique biological properties. Int J Oncol. 2011 Feb;38(2):335-44. DM43RV5 RU https://pubmed.ncbi.nlm.nih.gov/21152859 DMJNFI2 DI DMJNFI2 DMJNFI2 DN BMEC-1217B DMJNFI2 MI TTFTSHD DMJNFI2 MN Cytokine unspecific (CYK) DMJNFI2 MT DTT DMJNFI2 MA Regulator DMJNFI2 RN ClinicalTrials.gov (NCT00425971) Safety Study of Anti-Asthma Agent BMEC-1217B. U.S. National Institutes of Health. DMJNFI2 RU https://clinicaltrials.gov/ct2/show/NCT00425971 DMTZ3A6 DI DMTZ3A6 DMTZ3A6 DN BMS-196085 DMTZ3A6 MI TTMXGCW DMTZ3A6 MN Adrenergic receptor beta-3 (ADRB3) DMTZ3A6 MT DTT DMTZ3A6 MA Inhibitor DMTZ3A6 RN Arylpropanolamines: selective beta3 agonists arising from strategies to mitigate phase I metabolic transformations. Bioorg Med Chem Lett. 2007 Aug 1;17(15):4290-6. DMTZ3A6 RU https://pubmed.ncbi.nlm.nih.gov/17533126 DM5M48F DI DM5M48F DM5M48F DN BMS214662 DM5M48F MI TTXQKM3 DM5M48F MN Farnesyl protein transferase (Ftase) DM5M48F MT DTT DM5M48F MA Modulator DM5M48F RN Farnesyltransferase inhibitor BMS-214662 induces apoptosis in B-cell chronic lymphocytic leukemia cells. Leukemia. 2004 Oct;18(10):1599-604. DM5M48F RU https://www.ncbi.nlm.nih.gov/pubmed/15356656 DMGDJQR DI DMGDJQR DMGDJQR DN BMS-394136 DMGDJQR MI TTW0CMT DMGDJQR MN Voltage-gated potassium channel Kv1.5 (KCNA5) DMGDJQR MT DTT DMGDJQR MA Modulator DMGDJQR RN Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41. DMGDJQR RU https://www.ncbi.nlm.nih.gov/pubmed/15950434 DMPK32V DI DMPK32V DMPK32V DN BMS-754807 DMPK32V MI TTWTSCV DMPK32V MN RAC-alpha serine/threonine-protein kinase (AKT1) DMPK32V MT DTT DMPK32V MA Inhibitor DMPK32V RN Discovery of a 2,4-disubstituted pyrrolo[1,2-f][1,2,4]triazine inhibitor (BMS-754807) of insulin-like growth factor receptor (IGF-1R) kinase in cli... J Med Chem. 2009 Dec 10;52(23):7360-3. DMPK32V RU https://pubmed.ncbi.nlm.nih.gov/19778024 DMKR8S1 DI DMKR8S1 DMKR8S1 DN BMS-779788 DMKR8S1 MI TTM1EQF DMKR8S1 MN Oxysterols receptor LXR (NR1H) DMKR8S1 MT DTT DMKR8S1 MA Modulator DMKR8S1 RN Liver X receptors in lipid metabolism: opportunities for drug discovery. Nat Rev Drug Discov. 2014 Jun;13(6):433-44. DMKR8S1 RU https://pubmed.ncbi.nlm.nih.gov/24833295 DM2WMJ7 DI DM2WMJ7 DM2WMJ7 DN BMS-816336 DM2WMJ7 MI TTN7BL9 DM2WMJ7 MN Corticosteroid 11-beta-dehydrogenase 1 (HSD11B1) DM2WMJ7 MT DTT DM2WMJ7 MA Inhibitor DM2WMJ7 RN Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800027626) DM2WMJ7 RU http://adisinsight.springer.com/drugs/800027626 DMCX0H7 DI DMCX0H7 DMCX0H7 DN BMS-820132 DMCX0H7 MI TTDLNGZ DMCX0H7 MN Glucokinase (GCK) DMCX0H7 MT DTT DMCX0H7 MA Inhibitor DMCX0H7 RN Utilization of the Zucker Diabetic Fatty (ZDF) Rat Model for Investigating Hypoglycemia-related Toxicities. Toxicol Pathol. 2015 Aug;43(6):825-37. DMCX0H7 RU https://pubmed.ncbi.nlm.nih.gov/26085543 DMPQ5XC DI DMPQ5XC DMPQ5XC DN BMS-824383 DMPQ5XC MI TTCJ2X8 DMPQ5XC MN Hepatitis C virus Non-structural 5A (HCV NS5A) DMPQ5XC MT DTT DMPQ5XC MA Inhibitor DMPQ5XC RN 2011 Pipeline of Bristol-Myers Squibb. DMPQ5XC RU http://www.bms.com/pages/default.aspx DMCW71N DI DMCW71N DMCW71N DN BMS-830216 DMCW71N MI TTX4RTB DMCW71N MN Melanin-concentrating hormone receptor 1 (MCHR1) DMCW71N MT DTT DMCW71N MA Antagonist DMCW71N RN 2011 Pipeline of Bristol-Myers Squibb. DMCW71N RU http://www.bms.com/pages/default.aspx DMZS1D2 DI DMZS1D2 DMZS1D2 DN BMS-852927 DMZS1D2 MI TTM1EQF DMZS1D2 MN Oxysterols receptor LXR (NR1H) DMZS1D2 MT DTT DMZS1D2 MA Modulator DMZS1D2 RN Liver X receptors in lipid metabolism: opportunities for drug discovery. Nat Rev Drug Discov. 2014 Jun;13(6):433-44. DMZS1D2 RU https://pubmed.ncbi.nlm.nih.gov/24833295 DM7JW0B DI DM7JW0B DM7JW0B DN BMS-903452 DM7JW0B MI TT7QNVC DM7JW0B MN Glucose-dependent insulinotropic receptor (GPR119) DM7JW0B MT DTT DM7JW0B MA Modulator DM7JW0B RN Discovery of 5-chloro-4-((1-(5-chloropyrimidin-2-yl)piperidin-4-yl)oxy)-1-(2-fluoro-4-(methylsulfonyl)phenyl)pyridin-2(1H)-one (BMS-903452), an antidiabetic clinical candidate targeting GPR119. J MedChem. 2014 Sep 25;57(18):7499-508. DM7JW0B RU https://pubmed.ncbi.nlm.nih.gov/25208139 DM3K8VM DI DM3K8VM DM3K8VM DN BMS-908662 DM3K8VM MI TTWCGQT DM3K8VM MN Serine/threonine-protein kinase B-raf (BRAF) DM3K8VM MT DTT DM3K8VM MA Inhibitor DM3K8VM RN Clinical pipeline report, company report or official report of Exelixis (2011). DM3K8VM RU http://www.exelixis.com/pipeline DMG3J6C DI DMG3J6C DMG3J6C DN BMS-933043 DMG3J6C MI TTLA931 DMG3J6C MN Neuronal acetylcholine receptor alpha-7 (CHRNA7) DMG3J6C MT DTT DMG3J6C MA Modulator DMG3J6C RN Clinical pipeline report, company report or official report of Phrma.org Alzheimers 2012. DMG3J6C RU http://phrma.org/sites/default/files/pdf/alzheimers2012.pdf DMYIBFM DI DMYIBFM DMYIBFM DN BMS-936561 DMYIBFM MI TTNCIE0 DMYIBFM MN CD70 antigen (CD27-L) DMYIBFM MT DTT DMYIBFM MA Modulator DMYIBFM RN Pharmacokinetic characterization of BMS-936561, an anti-CD70 antibody-drug conjugate, in preclinical animal species and prediction of its pharmacok... Biopharm Drug Dispos. 2016 Mar;37(2):93-106. DMYIBFM RU https://pubmed.ncbi.nlm.nih.gov/25869904 DMS4H1J DI DMS4H1J DMS4H1J DN BMS-936564 DMS4H1J MI TTBID49 DMS4H1J MN C-X-C chemokine receptor type 4 (CXCR4) DMS4H1J MT DTT DMS4H1J MA Modulator DMS4H1J RN BMS-936564/MDX-1338: a fully human anti-CXCR4 antibody induces apoptosis in vitro and shows antitumor activity in vivo in hematologic malignancies. Clin Cancer Res. 2013 Jan 15;19(2):357-66. DMS4H1J RU https://pubmed.ncbi.nlm.nih.gov/23213054 DMZ4WMT DI DMZ4WMT DMZ4WMT DN BMS-986104 DMZ4WMT MI TT9JZCK DMZ4WMT MN Sphingosine-1-phosphate receptor 1 (S1PR1) DMZ4WMT MT DTT DMZ4WMT MA Modulator DMZ4WMT RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMZ4WMT RU http://phrma-docs.phrma.org/files/dmfile/medicines-in-development-drug-list-autoimmune-diseases.pdf DMYLFQR DI DMYLFQR DMYLFQR DN BMS-986120 DMYLFQR MI TT3I4WV DMYLFQR MN Prostate apoptosis response-4 (PAWR) DMYLFQR MT DTT DMYLFQR MA Antagonist DMYLFQR RN PAR4 (Protease-Activated Receptor 4) Antagonism With BMS-986120 Inhibits Human Ex Vivo Thrombus Formation. Arterioscler Thromb Vasc Biol. 2018 Feb;38(2):448-456. DMYLFQR RU https://pubmed.ncbi.nlm.nih.gov/29269513 DMXU5FK DI DMXU5FK DMXU5FK DN BMS-986189 DMXU5FK MI TT8ZLTI DMXU5FK MN Programmed cell death 1 ligand 1 (PD-L1) DMXU5FK MT DTT DMXU5FK MA Inhibitor DMXU5FK RN Development of Inhibitors of the Programmed Cell Death-1/Programmed Cell Death-Ligand 1 Signaling Pathway.J Med Chem. 2019 Feb 28;62(4):1715-1730. DMXU5FK RU https://pubmed.ncbi.nlm.nih.gov/30247903 DMHTEZ8 DI DMHTEZ8 DMHTEZ8 DN BMS-986249 DMHTEZ8 MI TTI2S1D DMHTEZ8 MN Cytotoxic T-lymphocyte protein 4 (CTLA-4) DMHTEZ8 MT DTT DMHTEZ8 RN Clinical pipeline report, company report or official report of CytomX Therapeutics. DMHTEZ8 RU https://cytomx.com/pipeline/ DMTMUWJ DI DMTMUWJ DMTMUWJ DN BMS-986299 DMTMUWJ MI TT4EN8X DMTMUWJ MN Caterpiller protein 1.1 (NLRP3) DMTMUWJ MT DTT DMTMUWJ MA Agonist DMTMUWJ RN National Cancer Institute Drug Dictionary (drug name BMS-986299). DMTMUWJ RU https://www.cancer.gov/publications/dictionaries/cancer-drug/def/nlrp3-agonist-bms-986299 DMM3DBU DI DMM3DBU DMM3DBU DN BMS-986301 DMM3DBU MI TTT402Y DMM3DBU MN Stimulator of interferon genes protein (TMEM173) DMM3DBU MT DTT DMM3DBU MA Agonist DMM3DBU RN Challenges and Opportunities in the Clinical Development of STING Agonists for Cancer Immunotherapy. J Clin Med. 2020 Oct 16;9(10):3323. DMM3DBU RU https://pubmed.ncbi.nlm.nih.gov/33081170 DMB6FMH DI DMB6FMH DMB6FMH DN BMTP-11 DMB6FMH MI TTZPLJS DMB6FMH MN Interleukin 11 receptor alpha (IL11RA) DMB6FMH MT DTT DMB6FMH MA Modulator DMB6FMH RN Targeting IL11 Receptor in Leukemia and Lymphoma: A Functional Ligand-Directed Study and Hematopathology Analysis of Patient-Derived Specimens. Clin Cancer Res. 2015 Jul 1;21(13):3041-51. DMB6FMH RU https://pubmed.ncbi.nlm.nih.gov/25779950 DMW8VEH DI DMW8VEH DMW8VEH DN BMY-43748 DMW8VEH MI TT0IHXV DMW8VEH MN DNA topoisomerase II (TOP2) DMW8VEH MT DTT DMW8VEH MA Modulator DMW8VEH RN Comparative metabolism of tosufloxacin and BMY 43748 in hepatocytes from rat, dog, monkey and man. Toxicol In Vitro. 1993 Jul;7(4):499-503. DMW8VEH RU https://pubmed.ncbi.nlm.nih.gov/20732241 DMSBM6A DI DMSBM6A DMSBM6A DN BNC-101 DMSBM6A MI TTTSGRH DMSBM6A MN Leucine-rich repeat-containing GPCR 5 (LGR5) DMSBM6A MT DTT DMSBM6A MA Inhibitor DMSBM6A RN Clinical pipeline report, company report or official report of Bionomics. DMSBM6A RU https://www.bionomics.com.au/research-development/pipeline/oncology DMI4UY3 DI DMI4UY3 DMI4UY3 DN BNC375 DMI4UY3 MI TTLA931 DMI4UY3 MN Neuronal acetylcholine receptor alpha-7 (CHRNA7) DMI4UY3 MT DTT DMI4UY3 MA Modulator DMI4UY3 RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMI4UY3 RU http://phrma-docs.phrma.org/files/dmfile/MID_Neurological-Disorders-Drug-List_2018.pdf DMU790L DI DMU790L DMU790L DN BOS172722 DMU790L MI TTP7EGM DMU790L MN Dual specificity protein kinase TTK (MPS1) DMU790L MT DTT DMU790L MA Inhibitor DMU790L RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMU790L RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DM9L0D8 DI DM9L0D8 DM9L0D8 DN BOS172738 DM9L0D8 MI TT4DXQT DM9L0D8 MN Proto-oncogene c-Ret (RET) DM9L0D8 MT DTT DM9L0D8 MA Inhibitor DM9L0D8 RN National Cancer Institute Drug Dictionary (drug name Zeteletinib). DM9L0D8 RU https://www.cancer.gov/publications/dictionaries/cancer-drug/def/zeteletinib DMI826O DI DMI826O DMI826O DN BP1002 DMI826O MI TTFOUV4 DMI826O MN BCL-2 messenger RNA (BCL2 mRNA) DMI826O MT DTT DMI826O MA Inhibitor DMI826O RN Clinical pipeline report, company report or official report of Bio-Path Holdings. DMI826O RU http://dnabilize.com/bp1002/ DMNY0U5 DI DMNY0U5 DMNY0U5 DN BPI-9016 M DMNY0U5 MI TTNDSF4 DMNY0U5 MN Proto-oncogene c-Met (MET) DMNY0U5 MT DTT DMNY0U5 MA Inhibitor DMNY0U5 RN First-in-human phase I study of BPI-9016M, a dual MET/Axl inhibitor, in patients with non-small cell lung cancer. J Hematol Oncol. 2020 Jan 16;13(1):6. DMNY0U5 RU https://pubmed.ncbi.nlm.nih.gov/31948451 DMNY0U5 DI DMNY0U5 DMNY0U5 DN BPI-9016 M DMNY0U5 MI TTZPY6J DMNY0U5 MN Tyrosine-protein kinase UFO (AXL) DMNY0U5 MT DTT DMNY0U5 MA Inhibitor DMNY0U5 RN First-in-human phase I study of BPI-9016M, a dual MET/Axl inhibitor, in patients with non-small cell lung cancer. J Hematol Oncol. 2020 Jan 16;13(1):6. DMNY0U5 RU https://pubmed.ncbi.nlm.nih.gov/31948451 DM51MSD DI DM51MSD DM51MSD DN BPX-101 DM51MSD MI TTIJP3Q DM51MSD MN TNF related activation protein (CD40LG) DM51MSD MT DTT DM51MSD RN Activation of antigen-exposed iMC-DCs at the ight place and ight time promotes potent anti-tumor immunity. Oncoimmunology. 2012 May 1; 1(3): 362-363. DM51MSD RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3382847/ DMYERSD DI DMYERSD DMYERSD DN BPX-701 DMYERSD MI TT7AKW1 DMYERSD MN T-cell receptor (TCR) DMYERSD MT DTT DMYERSD MA Immunomodulator DMYERSD RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMYERSD RU http://phrma-docs.phrma.org/files/dmfile/MID_Immuno-Oncology-2017_Drug-List1.pdf DMOQ2GB DI DMOQ2GB DMOQ2GB DN BR6819 DMOQ2GB MI TTYCILE DMOQ2GB MN Vasopressin receptor (VR) DMOQ2GB MT DTT DMOQ2GB MA Antagonist DMOQ2GB RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMOQ2GB RU http://phrma-docs.phrma.org/files/dmfile/2018_Heart-Disease-and-Stroke_MID-Drug-List.pdf DM4R6UV DI DM4R6UV DM4R6UV DN Bradykinin DM4R6UV MI DEGPI81 DM4R6UV MN Angiotensin-converting enzyme 2 (ACE2) DM4R6UV MT DME DM4R6UV MA Metabolism DM4R6UV RN Nunn's Applied Respiratory Physiology (Eighth Edition). Chapter 11 - Nonrespiratory Functions of the Lung.2017, Pages 203-214.e2 DM4R6UV RU https://www.sciencedirect.com/science/article/pii/B9780702062940000113 DM4R6UV DI DM4R6UV DM4R6UV DN Bradykinin DM4R6UV MI DEPWYLT DM4R6UV MN Arginine carboxypeptidase (CPN1) DM4R6UV MT DME DM4R6UV MA Metabolism DM4R6UV RN Regulation of chemerin bioactivity by plasma carboxypeptidase N, carboxypeptidase B (activated thrombin-activable fibrinolysis inhibitor), and platelets. J Biol Chem. 2009 Jan 9;284(2):751-8. DM4R6UV RU https://www.ncbi.nlm.nih.gov/pubmed/?term=19010784 DM4R6UV DI DM4R6UV DM4R6UV DN Bradykinin DM4R6UV MI TTGY8IW DM4R6UV MN B2 bradykinin receptor (BDKRB2) DM4R6UV MT DTT DM4R6UV MA Inhibitor DM4R6UV RN Synthesis and biological evaluation of bradykinin B(1)/B(2) and selective B(1) receptor antagonists. J Med Chem. 2000 Jun 15;43(12):2382-6. DM4R6UV RU https://pubmed.ncbi.nlm.nih.gov/10882364 DM4R6UV DI DM4R6UV DM4R6UV DN Bradykinin DM4R6UV MI DE1TNRG DM4R6UV MN Carboxypeptidase M (CPM) DM4R6UV MT DME DM4R6UV MA Metabolism DM4R6UV RN Interactions between carboxypeptidase M and kinin B1 receptor in endothelial cells. Inflamm Res. 2019 Oct;68(10):845-855. DM4R6UV RU https://www.ncbi.nlm.nih.gov/pubmed/?term=31218444 DM4R6UV DI DM4R6UV DM4R6UV DN Bradykinin DM4R6UV MI DEHEZPI DM4R6UV MN Cathepsin H (CTSH) DM4R6UV MT DME DM4R6UV MA Metabolism DM4R6UV RN Human brain cathepsin H as a neuropeptide and bradykinin metabolizing enzyme. Peptides. 2003 Dec;24(12):1977-84. DM4R6UV RU https://www.ncbi.nlm.nih.gov/pubmed/?term=15127951 DM4R6UV DI DM4R6UV DM4R6UV DN Bradykinin DM4R6UV MI DEG3S8C DM4R6UV MN Cathepsin K (CTSK) DM4R6UV MT DME DM4R6UV MA Metabolism DM4R6UV RN A cysteine-type carboxypeptidase, cathepsin X, generates peptide receptor agonists. Int Immunopharmacol. 2010 Jan;10(1):134-9. DM4R6UV RU https://www.ncbi.nlm.nih.gov/pubmed/?term=19800993 DM4R6UV DI DM4R6UV DM4R6UV DN Bradykinin DM4R6UV MI DEIORCK DM4R6UV MN Dipeptidyl peptidase II (DPP7) DM4R6UV MT DME DM4R6UV MA Metabolism DM4R6UV RN Purification of two dipeptidyl aminopeptidases II from rat brain and their action on proline-containing neuropeptides. J Neurochem. 1989 Apr;52(4):1284-93. DM4R6UV RU https://www.ncbi.nlm.nih.gov/pubmed/?term=2564425 DM4R6UV DI DM4R6UV DM4R6UV DN Bradykinin DM4R6UV MI DEKBXUC DM4R6UV MN PABA peptide hydrolase (MEP1B) DM4R6UV MT DME DM4R6UV MA Metabolism DM4R6UV RN Human and mouse homo-oligomeric meprin A metalloendopeptidase: substrate and inhibitor specificities. Biol Chem. 2007 Nov;388(11):1163-72. DM4R6UV RU https://www.ncbi.nlm.nih.gov/pubmed/?term=17976009 DM4R6UV DI DM4R6UV DM4R6UV DN Bradykinin DM4R6UV MI DEVSCNZ DM4R6UV MN Prolyl endopeptidase (PREP) DM4R6UV MT DME DM4R6UV MA Metabolism DM4R6UV RN Bradykinin release and inactivation in brain of rats submitted to an experimental model of Alzheimer's disease. Peptides. 2006 Dec;27(12):3363-9. DM4R6UV RU https://www.ncbi.nlm.nih.gov/pubmed/?term=17030465 DM4R6UV DI DM4R6UV DM4R6UV DN Bradykinin DM4R6UV MI DE8E6X9 DM4R6UV MN Soluble aminopeptidase P (sAmp) DM4R6UV MT DME DM4R6UV MA Metabolism DM4R6UV RN Cloning, expression, and characterization of human cytosolic aminopeptidase P: a single manganese(II)-dependent enzyme. Biochemistry. 2000 Dec 12;39(49):15121-8. DM4R6UV RU https://www.ncbi.nlm.nih.gov/pubmed/?term=11106490 DM4R6UV DI DM4R6UV DM4R6UV DN Bradykinin DM4R6UV MI DE95LJC DM4R6UV MN Thimet oligopeptidase (THOP1) DM4R6UV MT DME DM4R6UV MA Metabolism DM4R6UV RN Expression and activity of thimet oligopeptidase (TOP) are modified in the hippocampus of subjects with temporal lobe epilepsy (TLE). Epilepsia. 2014 May;55(5):754-62. DM4R6UV RU https://www.ncbi.nlm.nih.gov/pubmed/?term=24702695 DMK7BND DI DMK7BND DMK7BND DN Briciclib DMK7BND MI TTFCJ7S DMK7BND MN G1/S-specific cyclin-D1 (CCND1) DMK7BND MT DTT DMK7BND MA Inhibitor DMK7BND RN Clinical pipeline report, company report or official report of Onconova. DMK7BND RU http://www.onconova.com/product-pipeline/briciclib.php DM1V9YG DI DM1V9YG DM1V9YG DN BRL-52656 DM1V9YG MI TTQW87Y DM1V9YG MN Opioid receptor kappa (OPRK1) DM1V9YG MT DTT DM1V9YG MA Agonist DM1V9YG RN Kappa-opioid receptors behind the blood-brain barrier are involved in the anti-hypertensive effects of systemically administered kappa-agonists in the conscious spontaneously hypertensive rat. J Pharm Pharmacol. 1999 Nov;51(11):1251-6. DM1V9YG RU https://pubmed.ncbi.nlm.nih.gov/10632082 DMTDWIE DI DMTDWIE DMTDWIE DN BRX-005 DMTDWIE MI TTHYBIX DMTDWIE MN Heat shock protein 70 (HSP70) DMTDWIE MT DTT DMTDWIE MA Modulator DMTDWIE RN Cardiovascular effects of BRX-005 comparison to bimoclomol. Life Sci. 2000 Aug 25;67(14):1783-9. DMTDWIE RU https://pubmed.ncbi.nlm.nih.gov/11021362 DMS4H30 DI DMS4H30 DMS4H30 DN BT-063 DMS4H30 MI TTDB5IS DMS4H30 MN Receptor unspecific (Rec) DMS4H30 MT DTT DMS4H30 RN Clinical pipeline report, company report or official report of Biotest. DMS4H30 RU http://www.biotest.com/de/en/r_d/pipeline/bt063.cfm DMC8XHQ DI DMC8XHQ DMC8XHQ DN BTX-A51 DMC8XHQ MI TTFQEMX DMC8XHQ MN Casein kinase I alpha (CSNK1A1) DMC8XHQ MT DTT DMC8XHQ MA Inhibitor DMC8XHQ RN Clinical pipeline report, company report or official report of BioTheryX. DMC8XHQ RU https://www.biotheryx.com/pipeline/ DMC8XHQ DI DMC8XHQ DMC8XHQ DN BTX-A51 DMC8XHQ MI TTQYF7G DMC8XHQ MN Cyclin-dependent kinase 7 (CDK7) DMC8XHQ MT DTT DMC8XHQ MA Inhibitor DMC8XHQ RN Clinical pipeline report, company report or official report of BioTheryX. DMC8XHQ RU https://www.biotheryx.com/pipeline/ DMC8XHQ DI DMC8XHQ DMC8XHQ DN BTX-A51 DMC8XHQ MI TT1LVF2 DMC8XHQ MN Cyclin-dependent kinase 9 (CDK9) DMC8XHQ MT DTT DMC8XHQ MA Inhibitor DMC8XHQ RN Clinical pipeline report, company report or official report of BioTheryX. DMC8XHQ RU https://www.biotheryx.com/pipeline/ DMJ56MS DI DMJ56MS DMJ56MS DN BUTYLATEDHYDROXYTOLUENE DMJ56MS MI TTANPDJ DMJ56MS MN Carbonic anhydrase II (CA-II) DMJ56MS MT DTT DMJ56MS MA Inhibitor DMJ56MS RN Carbonic anhydrase inhibitors. Inhibition of human erythrocyte isozymes I and II with a series of antioxidant phenols. Bioorg Med Chem. 2009 Apr 15;17(8):3207-11. DMJ56MS RU https://pubmed.ncbi.nlm.nih.gov/19231207 DM43GPX DI DM43GPX DM43GPX DN BVI-007 DM43GPX MI TTCG5PE DM43GPX MN Thrombopoietin (THPO) DM43GPX MT DTT DM43GPX MA Inhibitor DM43GPX RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DM43GPX RU http://phrma-docs.phrma.org/files/dmfile/2018_Heart-Disease-and-Stroke_MID-Drug-List.pdf DM43GPX DI DM43GPX DM43GPX DN BVI-007 DM43GPX MI TTIHYA4 DM43GPX MN Thrombopoietin receptor (MPL) DM43GPX MT DTT DM43GPX MA Antagonist DM43GPX RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1722). DM43GPX RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1722 DMEP321 DI DMEP321 DMEP321 DN BVT-74316 DMEP321 MI TTJS8PY DMEP321 MN 5-HT 6 receptor (HTR6) DMEP321 MT DTT DMEP321 MA Antagonist DMEP321 RN Pharmacological targeting of the serotonergic system for the treatment of obesity. J Physiol. 2009 January 1; 587(Pt 1): 49-60. DMEP321 RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2670022/ DMY9L4C DI DMY9L4C DMY9L4C DN BXCL702 DMY9L4C MI TT3C1VN DMY9L4C MN Enzyme unspecific (Enz) DMY9L4C MT DTT DMY9L4C MA Inhibitor DMY9L4C RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMY9L4C RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DMH6B9J DI DMH6B9J DMH6B9J DN BZ-55 DMH6B9J MI DE5IED8 DMH6B9J MN Cytochrome P450 2C9 (CYP2C9) DMH6B9J MT DME DMH6B9J MA Metabolism DMH6B9J RN Clinically and pharmacologically relevant interactions of antidiabetic drugs. Ther Adv Endocrinol Metab. 2016 Apr;7(2):69-83. DMH6B9J RU https://www.ncbi.nlm.nih.gov/pubmed/?term=27092232 DMOV2ZD DI DMOV2ZD DMOV2ZD DN C188-9 DMOV2ZD MI TTHJT3X DMOV2ZD MN STAT3 messenger RNA (STAT3 mRNA) DMOV2ZD MT DTT DMOV2ZD MA Inhibitor DMOV2ZD RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMOV2ZD RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DMOFT1V DI DMOFT1V DMOFT1V DN C-2507 DMOFT1V MI TT5FH9Y DMOFT1V MN Human immunodeficiency virus Integrase (HIV IN) DMOFT1V MT DTT DMOFT1V MA Inhibitor DMOFT1V RN Elvitegravir: a new HIV integrase inhibitor. Antivir Chem Chemother. 2009 Oct 19;20(2):79-85. DMOFT1V RU https://pubmed.ncbi.nlm.nih.gov/19843978 DMR0S8U DI DMR0S8U DMR0S8U DN C326 DMR0S8U MI TTT1V78 DMR0S8U MN Interleukin-6 (IL6) DMR0S8U MT DTT DMR0S8U MA Inhibitor DMR0S8U RN The molecular basis of hepcidin-resistant hereditary hemochromatosis. Blood. 2009 Jul 9;114(2):437-43. DMR0S8U RU https://pubmed.ncbi.nlm.nih.gov/19383972 DMSO3JA DI DMSO3JA DMSO3JA DN C7R-GD2.CART cells DMSO3JA MI TT80ARU DMSO3JA MN Ganglioside GD2 (GD2) DMSO3JA MT DTT DMSO3JA MA CAR-T-Cell-Therapy DMSO3JA RN ClinicalTrials.gov (NCT03635632) C7R-GD2.CART Cells for Patients With Relapsed or Refractory Neuroblastoma (GAIL-N) DMSO3JA RU https://clinicaltrials.gov/ct2/show/NCT03635632 DMPQ1TM DI DMPQ1TM DMPQ1TM DN CA-011 DMPQ1TM MI TTMI6F5 DMPQ1TM MN Transient receptor potential cation channel V1 (TRPV1) DMPQ1TM MT DTT DMPQ1TM MA Agonist DMPQ1TM RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMPQ1TM RU http://phrma-docs.phrma.org/files/dmfile/MID_Neurological-Disorders-Drug-List_2018.pdf DMYDNQ2 DI DMYDNQ2 DMYDNQ2 DN CA102N DMYDNQ2 MI TTVKILB DMYDNQ2 MN Prostaglandin G/H synthase 2 (COX-2) DMYDNQ2 MT DTT DMYDNQ2 MA Inhibitor DMYDNQ2 RN National Cancer Institute Drug Dictionary (drug name CA102N). DMYDNQ2 RU https://www.cancer.gov/publications/dictionaries/cancer-drug/def/nimesulide-hyaluronic-acid-conjugate-ca102n DMOUHR4 DI DMOUHR4 DMOUHR4 DN CA-170 DMOUHR4 MI TT8ZLTI DMOUHR4 MN Programmed cell death 1 ligand 1 (PD-L1) DMOUHR4 MT DTT DMOUHR4 MA Inhibitor DMOUHR4 RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMOUHR4 RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DMQ2OP0 DI DMQ2OP0 DMQ2OP0 DN CA-170 DMQ2OP0 MI TT8ZLTI DMQ2OP0 MN Programmed cell death 1 ligand 1 (PD-L1) DMQ2OP0 MT DTT DMQ2OP0 MA Inhibitor DMQ2OP0 RN CA-170 - A Potent Small-Molecule PD-L1 Inhibitor or Not?. Molecules. 2019 Aug 1;24(15):2804. DMQ2OP0 RU https://pubmed.ncbi.nlm.nih.gov/31374878 DMOUHR4 DI DMOUHR4 DMOUHR4 DN CA-170 DMOUHR4 MI TT51SK8 DMOUHR4 MN V-set immunoregulatory receptor (VSIR) DMOUHR4 MT DTT DMOUHR4 MA Inhibitor DMOUHR4 RN Development of Inhibitors of the Programmed Cell Death-1/Programmed Cell Death-Ligand 1 Signaling Pathway.J Med Chem. 2019 Feb 28;62(4):1715-1730. DMOUHR4 RU https://pubmed.ncbi.nlm.nih.gov/30247903 DMWV8C6 DI DMWV8C6 DMWV8C6 DN CA-4948 DMWV8C6 MI TTKFVXR DMWV8C6 MN Renal carcinoma antigen NY-REN-64 (IRAK-4) DMWV8C6 MT DTT DMWV8C6 MA Inhibitor DMWV8C6 RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMWV8C6 RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DMA1QUC DI DMA1QUC DMA1QUC DN CAD-1833 DMA1QUC MI TTKU9YD DMA1QUC MN Calcium-activated potassium channel KCa2 (KCNN) DMA1QUC MT DTT DMA1QUC MA Modulator DMA1QUC RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMA1QUC RU http://phrma-docs.phrma.org/files/dmfile/MID_Neurological-Disorders-Drug-List_2018.pdf DMQ7WJI DI DMQ7WJI DMQ7WJI DN CAF-01 DMQ7WJI MI TT3J5ZI DMQ7WJI MN Cell mediated immunity response (CMIR) DMQ7WJI MT DTT DMQ7WJI MA Modulator DMQ7WJI RN Mechanisms of Action of Adjuvants. Front Immunol. 2013; 4: 114. DMQ7WJI RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3655441/ DMT4Z5B DI DMT4Z5B DMT4Z5B DN CALAA-01 DMT4Z5B MI TTBWDI0 DMT4Z5B MN Ribonucleoside-diphosphate reductase M2 (RRM2) DMT4Z5B MT DTT DMT4Z5B MA Modulator DMT4Z5B RN Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41. DMT4Z5B RU https://www.ncbi.nlm.nih.gov/pubmed/15950434 DMT4Z5B DI DMT4Z5B DMT4Z5B DN CALAA-01 DMT4Z5B MI TTV5YEH DMT4Z5B MN Transferrin (TF) DMT4Z5B MT DTT DMT4Z5B MA Modulator DMT4Z5B RN Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41. DMT4Z5B RU https://www.ncbi.nlm.nih.gov/pubmed/15950434 DMQTUH8 DI DMQTUH8 DMQTUH8 DN Calanolide A DMQTUH8 MI DE4LYSA DMQTUH8 MN Cytochrome P450 3A4 (CYP3A4) DMQTUH8 MT DME DMQTUH8 MA Metabolism DMQTUH8 RN Metabolism of F18, a derivative of calanolide A, in human liver microsomes and cytosol. Front Pharmacol. 2017 Jul 19;8:479. DMQTUH8 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=28769808 DMQTUH8 DI DMQTUH8 DMQTUH8 DN Calanolide A DMQTUH8 MI TT84ETX DMQTUH8 MN Human immunodeficiency virus Reverse transcriptase (HIV RT) DMQTUH8 MT DTT DMQTUH8 MA Inhibitor DMQTUH8 RN Calanolide A: a natural non-nucleoside reverse transcriptase inhibitor. BETA. 1999 Apr;12(2):8-9. DMQTUH8 RU https://pubmed.ncbi.nlm.nih.gov/11366704 DM1FLXD DI DM1FLXD DM1FLXD DN CAN04 DM1FLXD MI TTWS50K DM1FLXD MN Interleukin 1 receptor accessory protein (IL1RAP) DM1FLXD MT DTT DM1FLXD MA Inhibitor DM1FLXD RN A First-in-Human Study of CAN04 in Patients With Solid Malignant Tumors (CANFOUR) DM1FLXD RU https://clinicaltrials.gov/ct2/show/NCT03267316 DM9ERH1 DI DM9ERH1 DM9ERH1 DN Capravirine DM9ERH1 MI DES5XRU DM9ERH1 MN Cytochrome P450 2C8 (CYP2C8) DM9ERH1 MT DME DM9ERH1 MA Metabolism DM9ERH1 RN Identification of enzymes responsible for primary and sequential oxygenation reactions of capravirine in human liver microsomes. Drug Metab Dispos. 2006 Nov;34(11):1798-802. DM9ERH1 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=16914510 DM9ERH1 DI DM9ERH1 DM9ERH1 DN Capravirine DM9ERH1 MI DE5IED8 DM9ERH1 MN Cytochrome P450 2C9 (CYP2C9) DM9ERH1 MT DME DM9ERH1 MA Metabolism DM9ERH1 RN Identification of enzymes responsible for primary and sequential oxygenation reactions of capravirine in human liver microsomes. Drug Metab Dispos. 2006 Nov;34(11):1798-802. DM9ERH1 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=16914510 DM9ERH1 DI DM9ERH1 DM9ERH1 DN Capravirine DM9ERH1 MI DE4LYSA DM9ERH1 MN Cytochrome P450 3A4 (CYP3A4) DM9ERH1 MT DME DM9ERH1 MA Metabolism DM9ERH1 RN Identification of enzymes responsible for primary and sequential oxygenation reactions of capravirine in human liver microsomes. Drug Metab Dispos. 2006 Nov;34(11):1798-802. DM9ERH1 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=16914510 DM9ERH1 DI DM9ERH1 DM9ERH1 DN Capravirine DM9ERH1 MI TT84ETX DM9ERH1 MN Human immunodeficiency virus Reverse transcriptase (HIV RT) DM9ERH1 MT DTT DM9ERH1 MA Inhibitor DM9ERH1 RN Metabolism and excretion of capravirine, a new non-nucleoside reverse transcriptase inhibitor, alone and in combination with ritonavir in healthy volunteers. Drug Metab Dispos. 2004 Jul;32(7):689-98. DM9ERH1 RU https://pubmed.ncbi.nlm.nih.gov/15205383 DM9ERH1 DI DM9ERH1 DM9ERH1 DN Capravirine DM9ERH1 MI DEYGVN4 DM9ERH1 MN UDP-glucuronosyltransferase 1A1 (UGT1A1) DM9ERH1 MT DME DM9ERH1 MA Metabolism DM9ERH1 RN Metabolism and excretion of capravirine, a new non-nucleoside reverse transcriptase inhibitor, alone and in combination with ritonavir in healthy volunteers. Drug Metab Dispos. 2004 Jul;32(7):689-98. DM9ERH1 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=15205383 DM8NLPI DI DM8NLPI DM8NLPI DN CAR CD30 T cells DM8NLPI MI TT2GM5R DM8NLPI MN Lymphocyte activation antigen CD30 (TNFRSF8) DM8NLPI MT DTT DM8NLPI MA CAR-T-Cell-Therapy DM8NLPI RN ClinicalTrials.gov (NCT01316146) Administration of T Lymphocytes for Hodgkin's Lymphoma and Non-Hodgkin's Lymphoma (CART CD30) DM8NLPI RU https://clinicaltrials.gov/ct2/show/NCT01316146 DMA9M81 DI DMA9M81 DMA9M81 DN CAR138 T Cells DMA9M81 MI TTYDSVG DMA9M81 MN Syndecan-1 (SDC1) DMA9M81 MT DTT DMA9M81 MA CAR-T-Cell-Therapy DMA9M81 RN ClinicalTrials.gov (NCT03672318) Study of ATLCAR.CD138 Cells for Relapsed/Refractory Multiple Myeloma DMA9M81 RU https://clinicaltrials.gov/ct2/show/NCT03672318 DMXD4TC DI DMXD4TC DMXD4TC DN CAR19 T cells carrying cytoplasmic activated PD-1 DMXD4TC MI TTW640A DMXD4TC MN B-lymphocyte surface antigen B4 (CD19) DMXD4TC MT DTT DMXD4TC MA CAR-T-Cell-Therapy DMXD4TC RN ClinicalTrials.gov (NCT03540303) Cytoplasmic Activated PD-1 CAR T Cells in Refractory/Relapsed B Cell Lymphoma DMXD4TC RU https://clinicaltrials.gov/ct2/show/NCT03540303 DM4CXE2 DI DM4CXE2 DM4CXE2 DN CAR-20/19-T Cells DM4CXE2 MI TTW640A DM4CXE2 MN B-lymphocyte surface antigen B4 (CD19) DM4CXE2 MT DTT DM4CXE2 MA CAR-T-Cell-Therapy(Dual specific) DM4CXE2 RN ClinicalTrials.gov (NCT03375619) Long-term Follow-up Study of Patients Receiving CAR-20/19-T Cells DM4CXE2 RU https://clinicaltrials.gov/ct2/show/NCT03375619 DM4CXE2 DI DM4CXE2 DM4CXE2 DN CAR-20/19-T Cells DM4CXE2 MI TTUE541 DM4CXE2 MN Leukocyte surface antigen Leu-16 (CD20) DM4CXE2 MT DTT DM4CXE2 MA CAR-T-Cell-Therapy(Dual specific) DM4CXE2 RN ClinicalTrials.gov (NCT03375619) Long-term Follow-up Study of Patients Receiving CAR-20/19-T Cells DM4CXE2 RU https://clinicaltrials.gov/ct2/show/NCT03375619 DM4SNK8 DI DM4SNK8 DM4SNK8 DN CARD-024 DM4SNK8 MI TTB2MXP DM4SNK8 MN Angiotensinogenase renin (REN) DM4SNK8 MT DTT DM4SNK8 MA Agonist DM4SNK8 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2413). DM4SNK8 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2413 DM5WKU1 DI DM5WKU1 DM5WKU1 DN Cardiotrophin-1 DM5WKU1 MI TTXGTZU DM5WKU1 MN Cardiotrophin-1 (CTF1) DM5WKU1 MT DTT DM5WKU1 MA Stimulator DM5WKU1 RN Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41. DM5WKU1 RU https://www.ncbi.nlm.nih.gov/pubmed/15950434 DMQH2DK DI DMQH2DK DMQH2DK DN CAR-GPC3 T Cells DMQH2DK MI TTJTSX4 DMQH2DK MN Glypican-3 (GPC3) DMQH2DK MT DTT DMQH2DK MA CAR-T-Cell-Therapy DMQH2DK RN ClinicalTrials.gov (NCT02876978) Anti-GPC3 CAR T for Recurrent or Refractory Lung Squamous Cell Carcinoma DMQH2DK RU https://clinicaltrials.gov/ct2/show/NCT02876978 DMU6ZMX DI DMU6ZMX DMU6ZMX DN Carmoxirole DMU6ZMX MI TTEX248 DMU6ZMX MN Dopamine D2 receptor (D2R) DMU6ZMX MT DTT DMU6ZMX MA Agonist DMU6ZMX RN Neurohumoral response to carmoxirole, a selective dopamine (D2) receptor agonist, in patients with chronic moderate heart failure. Cardiovasc Drugs Ther. 1998 Sep;12(4):387-94. DMU6ZMX RU https://pubmed.ncbi.nlm.nih.gov/9825185 DMC7Y5F DI DMC7Y5F DMC7Y5F DN CAR-T cells recognizing EpCAM DMC7Y5F MI TTZ8WH4 DMC7Y5F MN Tumor-associated calcium signal transducer 1 (EPCAM) DMC7Y5F MT DTT DMC7Y5F MA CAR-T-Cell-Therapy DMC7Y5F RN ClinicalTrials.gov (NCT02915445) EpCAM CAR-T for Treatment of Nasopharyngeal Carcinoma and Breast Cancer DMC7Y5F RU https://clinicaltrials.gov/ct2/show/NCT02915445 DMTZADW DI DMTZADW DMTZADW DN CAR-T cells targeting BCMA DMTZADW MI TTZ3P4W DMTZADW MN B-cell maturation protein (TNFRSF17) DMTZADW MT DTT DMTZADW MA CAR-T-Cell-Therapy DMTZADW RN ClinicalTrials.gov (NCT03672253) CAR-T Re-treatment for Refractory/Relapsed Multiple Myeloma DMTZADW RU https://clinicaltrials.gov/ct2/show/NCT03672253 DM3AHNX DI DM3AHNX DM3AHNX DN CAR-T Cells targeting CD19 DM3AHNX MI TTW640A DM3AHNX MN B-lymphocyte surface antigen B4 (CD19) DM3AHNX MT DTT DM3AHNX MA CAR-T-Cell-Therapy DM3AHNX RN ClinicalTrials.gov (NCT03186118) Pilot Study of T-APCs Following CAR T Cell Immunotherapy for CD19+ Leukemia DM3AHNX RU https://clinicaltrials.gov/ct2/show/NCT03186118 DMJK1R0 DI DMJK1R0 DMJK1R0 DN CAR-T cells targeting CD19 DMJK1R0 MI TTW640A DMJK1R0 MN B-lymphocyte surface antigen B4 (CD19) DMJK1R0 MT DTT DMJK1R0 MA CAR-T-Cell-Therapy DMJK1R0 RN ClinicalTrials.gov (NCT03086954) Study Evaluating the Efficacy and Safety With CAR-T Immunotherapy for CD19 Positive Lymphoma DMJK1R0 RU https://clinicaltrials.gov/ct2/show/NCT03086954 DM6Z7AD DI DM6Z7AD DM6Z7AD DN CAR-T cells targeting CD80/86 DM6Z7AD MI TTFZDNP DM6Z7AD MN Activation B7-1 antigen (CD80) DM6Z7AD MT DTT DM6Z7AD MA CAR-T-Cell-Therapy DM6Z7AD RN ClinicalTrials.gov (NCT03198052) HER2/Mesothelin/Lewis-Y/PSCA/MUC1/PD-L1/CD80/86-CAR-T Cells Immunotherapy Against Cancers DM6Z7AD RU https://clinicaltrials.gov/ct2/show/NCT03198052 DMX4ZDY DI DMX4ZDY DMX4ZDY DN CAR-T Cells targeting CEA DMX4ZDY MI TTY6DTE DMX4ZDY MN Carcinoembryonic antigen CEA (CD66e) DMX4ZDY MT DTT DMX4ZDY MA CAR-T-Cell-Therapy DMX4ZDY RN ClinicalTrials.gov (NCT03267173) Evaluate the Safety and Efficacy of CAR-T in the Treatment of Pancreatic Cancer. DMX4ZDY RU https://clinicaltrials.gov/ct2/show/NCT03267173 DMRSG04 DI DMRSG04 DMRSG04 DN CAR-T cells targeting EGFRviii DMRSG04 MI TTZ6B2I DMRSG04 MN Epidermal growth factor receptor variant III (EGFR vIII) DMRSG04 MT DTT DMRSG04 MA CAR-T-Cell-Therapy DMRSG04 RN ClinicalTrials.gov (NCT03170141) Immunogene-modified T (IgT) Cells Against Glioblastoma Multiforme DMRSG04 RU https://clinicaltrials.gov/ct2/show/NCT03170141 DMWAMNT DI DMWAMNT DMWAMNT DN CAR-T Cells targeting EGFRvIII DMWAMNT MI TTZ6B2I DMWAMNT MN Epidermal growth factor receptor variant III (EGFR vIII) DMWAMNT MT DTT DMWAMNT MA CAR-T-Cell-Therapy DMWAMNT RN ClinicalTrials.gov (NCT03267173) Evaluate the Safety and Efficacy of CAR-T in the Treatment of Pancreatic Cancer. DMWAMNT RU https://clinicaltrials.gov/ct2/show/NCT03267173 DMQ2Y1J DI DMQ2Y1J DMQ2Y1J DN CAR-T cells targeting EpCAM DMQ2Y1J MI TTZ8WH4 DMQ2Y1J MN Tumor-associated calcium signal transducer 1 (EPCAM) DMQ2Y1J MT DTT DMQ2Y1J MA CAR-T-Cell-Therapy DMQ2Y1J RN ClinicalTrials.gov (NCT03563326) Intraperitoneal Infusion of EpCAM CAR-T Cell in Advanced Gastric Cancer With Peritoneal Metastasis (WCH-GC-CART) DMQ2Y1J RU https://clinicaltrials.gov/ct2/show/NCT03563326 DMYCMNR DI DMYCMNR DMYCMNR DN CAR-T Cells targeting HER2 DMYCMNR MI TT6EO5L DMYCMNR MN Erbb2 tyrosine kinase receptor (HER2) DMYCMNR MT DTT DMYCMNR MA CAR-T-Cell-Therapy DMYCMNR RN ClinicalTrials.gov (NCT03267173) Evaluate the Safety and Efficacy of CAR-T in the Treatment of Pancreatic Cancer. DMYCMNR RU https://clinicaltrials.gov/ct2/show/NCT03267173 DMLI5VG DI DMLI5VG DMLI5VG DN CAR-T cells targeting HER2 DMLI5VG MI TT6EO5L DMLI5VG MN Erbb2 tyrosine kinase receptor (HER2) DMLI5VG MT DTT DMLI5VG MA CAR-T-Cell-Therapy DMLI5VG RN ClinicalTrials.gov (NCT03198052) HER2/Mesothelin/Lewis-Y/PSCA/MUC1/PD-L1/CD80/86-CAR-T Cells Immunotherapy Against Cancers DMLI5VG RU https://clinicaltrials.gov/ct2/show/NCT03198052 DMGI58S DI DMGI58S DMGI58S DN CAR-T cells targeting Lewis-Y DMGI58S MI TTV75BJ DMGI58S MN Carbohydrate antigen Lewis-Y (Lewis-Y) DMGI58S MT DTT DMGI58S MA CAR-T-Cell-Therapy DMGI58S RN ClinicalTrials.gov (NCT03198052) HER2/Mesothelin/Lewis-Y/PSCA/MUC1/PD-L1/CD80/86-CAR-T Cells Immunotherapy Against Cancers DMGI58S RU https://clinicaltrials.gov/ct2/show/NCT03198052 DMTZXSO DI DMTZXSO DMTZXSO DN CAR-T cells targeting Mesothelin DMTZXSO MI TT4RXME DMTZXSO MN Mesothelin (MSLN) DMTZXSO MT DTT DMTZXSO MA CAR-T-Cell-Therapy DMTZXSO RN ClinicalTrials.gov (NCT03198052) HER2/Mesothelin/Lewis-Y/PSCA/MUC1/PD-L1/CD80/86-CAR-T Cells Immunotherapy Against Cancers DMTZXSO RU https://clinicaltrials.gov/ct2/show/NCT03198052 DM6DULC DI DM6DULC DM6DULC DN CAR-T Cells targeting Mesothelin DM6DULC MI TT4RXME DM6DULC MN Mesothelin (MSLN) DM6DULC MT DTT DM6DULC MA CAR-T-Cell-Therapy DM6DULC RN ClinicalTrials.gov (NCT03267173) Evaluate the Safety and Efficacy of CAR-T in the Treatment of Pancreatic Cancer. DM6DULC RU https://clinicaltrials.gov/ct2/show/NCT03267173 DM6GRNC DI DM6GRNC DM6GRNC DN CAR-T cells targeting MUC1 DM6GRNC MI TTBHFYQ DM6GRNC MN Mucin-1 (MUC1) DM6GRNC MT DTT DM6GRNC MA CAR-T-Cell-Therapy DM6GRNC RN ClinicalTrials.gov (NCT03198052) HER2/Mesothelin/Lewis-Y/PSCA/MUC1/PD-L1/CD80/86-CAR-T Cells Immunotherapy Against Cancers DM6GRNC RU https://clinicaltrials.gov/ct2/show/NCT03198052 DMNH1Y5 DI DMNH1Y5 DMNH1Y5 DN CAR-T Cells targeting MUCI DMNH1Y5 MI TTBHFYQ DMNH1Y5 MN Mucin-1 (MUC1) DMNH1Y5 MT DTT DMNH1Y5 MA CAR-T-Cell-Therapy DMNH1Y5 RN ClinicalTrials.gov (NCT03267173) Evaluate the Safety and Efficacy of CAR-T in the Treatment of Pancreatic Cancer. DMNH1Y5 RU https://clinicaltrials.gov/ct2/show/NCT03267173 DMWIXLC DI DMWIXLC DMWIXLC DN CAR-T Cells targeting PSCA DMWIXLC MI TT9T4AV DMWIXLC MN Prostate stem cell antigen (PSCA) DMWIXLC MT DTT DMWIXLC MA CAR-T-Cell-Therapy DMWIXLC RN ClinicalTrials.gov (NCT03267173) Evaluate the Safety and Efficacy of CAR-T in the Treatment of Pancreatic Cancer. DMWIXLC RU https://clinicaltrials.gov/ct2/show/NCT03267173 DMU4G9J DI DMU4G9J DMU4G9J DN CAR-T cells targeting PSCA DMU4G9J MI TT9T4AV DMU4G9J MN Prostate stem cell antigen (PSCA) DMU4G9J MT DTT DMU4G9J MA CAR-T-Cell-Therapy DMU4G9J RN ClinicalTrials.gov (NCT03198052) HER2/Mesothelin/Lewis-Y/PSCA/MUC1/PD-L1/CD80/86-CAR-T Cells Immunotherapy Against Cancers DMU4G9J RU https://clinicaltrials.gov/ct2/show/NCT03198052 DMQ4UJ6 DI DMQ4UJ6 DMQ4UJ6 DN CART-10 cells DMQ4UJ6 MI TT5TKPM DMQ4UJ6 MN Neutral endopeptidase (MME) DMQ4UJ6 MT DTT DMQ4UJ6 MA CAR-T-Cell-Therapy DMQ4UJ6 RN ClinicalTrials.gov (NCT03291444) CAR-T Cells Combined With Peptide Specific Dendritic Cell in Relapsed/Refractory Leukemia/MDS DMQ4UJ6 RU https://clinicaltrials.gov/ct2/show/NCT03291444 DMAKZTW DI DMAKZTW DMAKZTW DN CART-117 cells DMAKZTW MI TTX41N9 DMAKZTW MN Tyrosine-protein kinase Kit (KIT) DMAKZTW MT DTT DMAKZTW MA CAR-T-Cell-Therapy DMAKZTW RN ClinicalTrials.gov (NCT03291444) CAR-T Cells Combined With Peptide Specific Dendritic Cell in Relapsed/Refractory Leukemia/MDS DMAKZTW RU https://clinicaltrials.gov/ct2/show/NCT03291444 DMD0XWR DI DMD0XWR DMD0XWR DN CART123 cells DMD0XWR MI TTENHJ0 DMD0XWR MN Interleukin 3 receptor alpha (IL3RA) DMD0XWR MT DTT DMD0XWR MA CAR-T-Cell-Therapy DMD0XWR RN ClinicalTrials.gov (NCT03766126) Lentivirally Redirected CD123 Autologous T Cells in AML DMD0XWR RU https://clinicaltrials.gov/ct2/show/NCT03766126 DMEN6YF DI DMEN6YF DMEN6YF DN CART-123 cells DMEN6YF MI TTENHJ0 DMEN6YF MN Interleukin 3 receptor alpha (IL3RA) DMEN6YF MT DTT DMEN6YF MA CAR-T-Cell-Therapy DMEN6YF RN ClinicalTrials.gov (NCT03291444) CAR-T Cells Combined With Peptide Specific Dendritic Cell in Relapsed/Refractory Leukemia/MDS DMEN6YF RU https://clinicaltrials.gov/ct2/show/NCT03291444 DM1R8P4 DI DM1R8P4 DM1R8P4 DN CART-19 DM1R8P4 MI TTW640A DM1R8P4 MN B-lymphocyte surface antigen B4 (CD19) DM1R8P4 MT DTT DM1R8P4 MA CAR-T-Cell-Therapy DM1R8P4 RN ClinicalTrials.gov (NCT03101709) The Safety and Efficacy of CART-19 Cells in Relapse and Refractory Patients With CD19+ B-cell Lymphoma DM1R8P4 RU https://clinicaltrials.gov/ct2/show/NCT03101709 DM8R2ZX DI DM8R2ZX DM8R2ZX DN CART-19 DM8R2ZX MI TTW640A DM8R2ZX MN B-lymphocyte surface antigen B4 (CD19) DM8R2ZX MT DTT DM8R2ZX MA CAR-T-Cell-Therapy DM8R2ZX RN ClinicalTrials.gov (NCT02810223) Efficacy of CART-19 Cell Therapy in B Cell Acute Lymphoblastic Leukemia DM8R2ZX RU https://clinicaltrials.gov/ct2/show/NCT02810223 DMY218P DI DMY218P DMY218P DN CART-19 autologous T-cells DMY218P MI TTW640A DMY218P MN B-lymphocyte surface antigen B4 (CD19) DMY218P MT DTT DMY218P MA CAR-T-Cell-Therapy DMY218P RN ClinicalTrials.gov (NCT02476734) FDG-PET/CT Imaging as Early Predictor of DP DMY218P RU https://clinicaltrials.gov/ct2/show/NCT02476734 DMM95XS DI DMM95XS DMM95XS DN CART19 cell DMM95XS MI TTW640A DMM95XS MN B-lymphocyte surface antigen B4 (CD19) DMM95XS MT DTT DMM95XS MA CAR-T-Cell-Therapy DMM95XS RN ClinicalTrials.gov (NCT03685786) CART19 Cells Treatment of MRD of B Cell Malignancies and Then Auto-HSCT DMM95XS RU https://clinicaltrials.gov/ct2/show/NCT03685786 DMHWVY1 DI DMHWVY1 DMHWVY1 DN CART-19 cells DMHWVY1 MI TTW640A DMHWVY1 MN B-lymphocyte surface antigen B4 (CD19) DMHWVY1 MT DTT DMHWVY1 MA CAR-T-Cell-Therapy DMHWVY1 RN ClinicalTrials.gov (NCT03291444) CAR-T Cells Combined With Peptide Specific Dendritic Cell in Relapsed/Refractory Leukemia/MDS DMHWVY1 RU https://clinicaltrials.gov/ct2/show/NCT03291444 DMKW27X DI DMKW27X DMKW27X DN CART-19 cells DMKW27X MI TTW640A DMKW27X MN B-lymphocyte surface antigen B4 (CD19) DMKW27X MT DTT DMKW27X MA CAR-T-Cell-Therapy DMKW27X RN ClinicalTrials.gov (NCT02924753) The Safety and Efficacy of CART-19 Cells in B-cell Acute Lymphoblastic Leukemia (B-ALL). DMKW27X RU https://clinicaltrials.gov/ct2/show/NCT02924753 DMTCB8I DI DMTCB8I DMTCB8I DN CART-19 T cells DMTCB8I MI TTW640A DMTCB8I MN B-lymphocyte surface antigen B4 (CD19) DMTCB8I MT DTT DMTCB8I MA CAR-T-Cell-Therapy DMTCB8I RN ClinicalTrials.gov (NCT02135406) CART-19 for Multiple Myeloma DMTCB8I RU https://clinicaltrials.gov/ct2/show/NCT02135406 DMR0Z65 DI DMR0Z65 DMR0Z65 DN CART-20 cells DMR0Z65 MI TTUE541 DMR0Z65 MN Leukocyte surface antigen Leu-16 (CD20) DMR0Z65 MT DTT DMR0Z65 MA CAR-T-Cell-Therapy DMR0Z65 RN ClinicalTrials.gov (NCT03291444) CAR-T Cells Combined With Peptide Specific Dendritic Cell in Relapsed/Refractory Leukemia/MDS DMR0Z65 RU https://clinicaltrials.gov/ct2/show/NCT03291444 DM6X82R DI DM6X82R DM6X82R DN CART22 cells DM6X82R MI TTM6QSK DM6X82R MN B-cell receptor CD22 (CD22) DM6X82R MT DTT DM6X82R MA CAR-T-Cell-Therapy DM6X82R RN ClinicalTrials.gov (NCT02588456) Pilot Study of Autologous Anti-CD22 Chimeric Antigen Receptor Redirected T Cells In Patients With Chemotherapy Resistant Or Refractory Acute Lymphoblastic Leukemia DM6X82R RU https://clinicaltrials.gov/ct2/show/NCT02588456 DMLGJKE DI DMLGJKE DMLGJKE DN CART-22 cells DMLGJKE MI TTM6QSK DMLGJKE MN B-cell receptor CD22 (CD22) DMLGJKE MT DTT DMLGJKE MA CAR-T-Cell-Therapy DMLGJKE RN ClinicalTrials.gov (NCT03291444) CAR-T Cells Combined With Peptide Specific Dendritic Cell in Relapsed/Refractory Leukemia/MDS DMLGJKE RU https://clinicaltrials.gov/ct2/show/NCT03291444 DMY3NWK DI DMY3NWK DMY3NWK DN CART22 cells expressing anti-CD22 scFv TCRz:41BB DMY3NWK MI TTM6QSK DMY3NWK MN B-cell receptor CD22 (CD22) DMY3NWK MT DTT DMY3NWK MA CAR-T-Cell-Therapy DMY3NWK RN ClinicalTrials.gov (NCT02650414) CD22 Redirected Autologous T Cells for ALL DMY3NWK RU https://clinicaltrials.gov/ct2/show/NCT02650414 DM4XT15 DI DM4XT15 DM4XT15 DN CART22-65s cells DM4XT15 MI TTM6QSK DM4XT15 MN B-cell receptor CD22 (CD22) DM4XT15 MT DTT DM4XT15 MA CAR-T-Cell-Therapy DM4XT15 RN ClinicalTrials.gov (NCT03620058) CART22 Alone or in Combination With huCART19 for ALL DM4XT15 RU https://clinicaltrials.gov/ct2/show/NCT03620058 DMOJ1AH DI DMOJ1AH DMOJ1AH DN CART22-65s cells and huCART19 Cells DMOJ1AH MI TTM6QSK DMOJ1AH MN B-cell receptor CD22 (CD22) DMOJ1AH MT DTT DMOJ1AH MA CAR-T-Cell-Therapy(Dual specific) DMOJ1AH RN ClinicalTrials.gov (NCT03620058) CART22 Alone or in Combination With huCART19 for ALL DMOJ1AH RU https://clinicaltrials.gov/ct2/show/NCT03620058 DMOJ1AH DI DMOJ1AH DMOJ1AH DN CART22-65s cells and huCART19 Cells DMOJ1AH MI TTW640A DMOJ1AH MN B-lymphocyte surface antigen B4 (CD19) DMOJ1AH MT DTT DMOJ1AH MA CAR-T-Cell-Therapy(Dual specific) DMOJ1AH RN ClinicalTrials.gov (NCT03620058) CART22 Alone or in Combination With huCART19 for ALL DMOJ1AH RU https://clinicaltrials.gov/ct2/show/NCT03620058 DMBHCSL DI DMBHCSL DMBHCSL DN CART-33 cells DMBHCSL MI TTJVYO3 DMBHCSL MN Myeloid cell surface antigen CD33 (CD33) DMBHCSL MT DTT DMBHCSL MA CAR-T-Cell-Therapy DMBHCSL RN ClinicalTrials.gov (NCT03291444) CAR-T Cells Combined With Peptide Specific Dendritic Cell in Relapsed/Refractory Leukemia/MDS DMBHCSL RU https://clinicaltrials.gov/ct2/show/NCT03291444 DMRNIB9 DI DMRNIB9 DMRNIB9 DN CART-34 cells DMRNIB9 MI TTZAVYN DMRNIB9 MN Hematopoietic progenitor cell antigen CD34 (CD34) DMRNIB9 MT DTT DMRNIB9 MA CAR-T-Cell-Therapy DMRNIB9 RN ClinicalTrials.gov (NCT03291444) CAR-T Cells Combined With Peptide Specific Dendritic Cell in Relapsed/Refractory Leukemia/MDS DMRNIB9 RU https://clinicaltrials.gov/ct2/show/NCT03291444 DMKN8XD DI DMKN8XD DMKN8XD DN CART-38 cells DMKN8XD MI TTPURFN DMKN8XD MN Cyclic ADP-ribose hydrolase 1 (CD38) DMKN8XD MT DTT DMKN8XD MA CAR-T-Cell-Therapy DMKN8XD RN ClinicalTrials.gov (NCT03291444) CAR-T Cells Combined With Peptide Specific Dendritic Cell in Relapsed/Refractory Leukemia/MDS DMKN8XD RU https://clinicaltrials.gov/ct2/show/NCT03291444 DMQTOBF DI DMQTOBF DMQTOBF DN CART-56 cells DMQTOBF MI TTVXPHT DMQTOBF MN Neural cell adhesion molecule 1 (NCAM1) DMQTOBF MT DTT DMQTOBF MA CAR-T-Cell-Therapy DMQTOBF RN ClinicalTrials.gov (NCT03291444) CAR-T Cells Combined With Peptide Specific Dendritic Cell in Relapsed/Refractory Leukemia/MDS DMQTOBF RU https://clinicaltrials.gov/ct2/show/NCT03291444 DMVK3M2 DI DMVK3M2 DMVK3M2 DN CART-BCMA DMVK3M2 MI TTZ3P4W DMVK3M2 MN B-cell maturation protein (TNFRSF17) DMVK3M2 MT DTT DMVK3M2 MA CAR-T-Cell-Therapy DMVK3M2 RN ClinicalTrials.gov (NCT02546167) CART-BCMA Cells for Multiple Myeloma DMVK3M2 RU https://clinicaltrials.gov/ct2/show/NCT02546167 DM4OWJ8 DI DM4OWJ8 DM4OWJ8 DN CART-ddBCMA DM4OWJ8 MI TTZ3P4W DM4OWJ8 MN B-cell maturation protein (TNFRSF17) DM4OWJ8 MT DTT DM4OWJ8 RN Clinical pipeline report, company report or official report of Arcellx. DM4OWJ8 RU https://arcellx.com/pipeline/overview/ DMGPR1C DI DMGPR1C DMGPR1C DN CART-EGFRvIII T cells DMGPR1C MI TTZ6B2I DMGPR1C MN Epidermal growth factor receptor variant III (EGFR vIII) DMGPR1C MT DTT DMGPR1C MA CAR-T-Cell-Therapy DMGPR1C RN ClinicalTrials.gov (NCT02209376) Autologous T Cells Redirected to EGFRVIII-With a Chimeric Antigen Receptor in Patients With EGFRVIII+ Glioblastoma DMGPR1C RU https://clinicaltrials.gov/ct2/show/NCT02209376 DM90QPK DI DM90QPK DM90QPK DN CART-meso cells DM90QPK MI TT4RXME DM90QPK MN Mesothelin (MSLN) DM90QPK MT DTT DM90QPK MA CAR-T-Cell-Therapy DM90QPK RN ClinicalTrials.gov (NCT02159716) CART-meso in Mesothelin Expressing Cancers DM90QPK RU https://clinicaltrials.gov/ct2/show/NCT02159716 DMV84ZR DI DMV84ZR DMV84ZR DN CARTmeso/19 DMV84ZR MI TTW640A DMV84ZR MN B-lymphocyte surface antigen B4 (CD19) DMV84ZR MT DTT DMV84ZR MA CAR-T-Cell-Therapy(Dual specific) DMV84ZR RN ClinicalTrials.gov (NCT03497819) Autologous CARTmeso/19 Against Pancreatic Cancer DMV84ZR RU https://clinicaltrials.gov/ct2/show/NCT03497819 DMV84ZR DI DMV84ZR DMV84ZR DN CARTmeso/19 DMV84ZR MI TT4RXME DMV84ZR MN Mesothelin (MSLN) DMV84ZR MT DTT DMV84ZR MA CAR-T-Cell-Therapy(Dual specific) DMV84ZR RN ClinicalTrials.gov (NCT03497819) Autologous CARTmeso/19 Against Pancreatic Cancer DMV84ZR RU https://clinicaltrials.gov/ct2/show/NCT03497819 DMZ4I03 DI DMZ4I03 DMZ4I03 DN CART-meso-19 T cells DMZ4I03 MI TTW640A DMZ4I03 MN B-lymphocyte surface antigen B4 (CD19) DMZ4I03 MT DTT DMZ4I03 MA CAR-T-Cell-Therapy(Dual specific) DMZ4I03 RN ClinicalTrials.gov (NCT02465983) Pilot Study of Autologous T-cells in Patients With Metastatic Pancreatic Cancer DMZ4I03 RU https://clinicaltrials.gov/ct2/show/NCT02465983 DMZ4I03 DI DMZ4I03 DMZ4I03 DN CART-meso-19 T cells DMZ4I03 MI TT4RXME DMZ4I03 MN Mesothelin (MSLN) DMZ4I03 MT DTT DMZ4I03 MA CAR-T-Cell-Therapy(Dual specific) DMZ4I03 RN ClinicalTrials.gov (NCT02465983) Pilot Study of Autologous T-cells in Patients With Metastatic Pancreatic Cancer DMZ4I03 RU https://clinicaltrials.gov/ct2/show/NCT02465983 DMOJEXG DI DMOJEXG DMOJEXG DN CART-Muc1 cells DMOJEXG MI TTBHFYQ DMOJEXG MN Mucin-1 (MUC1) DMOJEXG MT DTT DMOJEXG MA CAR-T-Cell-Therapy DMOJEXG RN ClinicalTrials.gov (NCT03291444) CAR-T Cells Combined With Peptide Specific Dendritic Cell in Relapsed/Refractory Leukemia/MDS DMOJEXG RU https://clinicaltrials.gov/ct2/show/NCT03291444 DM39LPN DI DM39LPN DM39LPN DN CarVAC DM39LPN MI TTW640A DM39LPN MN B-lymphocyte surface antigen B4 (CD19) DM39LPN MT DTT DM39LPN RN ClinicalTrials.gov (NCT04156243) CD19 CARvac T Cells for Patients With Relapsed / Refractory B Cell Malignancies. U.S. National Institutes of Health. DM39LPN RU https://clinicaltrials.gov/ct2/show/NCT04156243 DMO53AD DI DMO53AD DMO53AD DN Cavrotolimod DMO53AD MI TTSHG0T DMO53AD MN Toll-like receptor 9 (TLR9) DMO53AD MT DTT DMO53AD MA Agonist DMO53AD RN Clinical pipeline report, company report or official report of Exicure. DMO53AD RU https://www.exicuretx.com/pipeline/index.php DM12GN7 DI DM12GN7 DM12GN7 DN CB-5083 DM12GN7 MI TTHNLSB DM12GN7 MN Valosin-containing protein p97 (VCP) DM12GN7 MT DTT DM12GN7 MA Inhibitor DM12GN7 RN Pharmacological targeting of valosin containing protein (VCP) induces DNA damage and selectively kills canine lymphoma cells. BMC Cancer. 2015; 15: 479. DM12GN7 RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4479320/ DMOXDIY DI DMOXDIY DMOXDIY DN CB-5339 DMOXDIY MI TTHNLSB DMOXDIY MN Valosin-containing protein p97 (VCP) DMOXDIY MT DTT DMOXDIY MA Inhibitor DMOXDIY RN Clinical pipeline report, company report or official report of Cleave Therapeutics. DMOXDIY RU https://www.casipharmaceuticals.com/product-pipeline/cb-5339/ DMXQGKL DI DMXQGKL DMXQGKL DN CB-813 DMXQGKL MI TTF0EGX DMXQGKL MN Coagulation factor VII (F7) DMXQGKL MT DTT DMXQGKL MA Modulator DMXQGKL RN Clinical pipeline report, company report or official report of Catalyst Biosciences. DMXQGKL RU http://www.catalystbiosciences.com/news/15-06-24/ DMORN60 DI DMORN60 DMORN60 DN CBL0137 DMORN60 MI TTETDKQ DMORN60 MN Facilitates chromatin transcription complex (FACT) DMORN60 MT DTT DMORN60 MA Modulator DMORN60 RN Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41. DMORN60 RU https://www.ncbi.nlm.nih.gov/pubmed/15950434 DMOTLN4 DI DMOTLN4 DMOTLN4 DN CBT-101 DMOTLN4 MI TTNDSF4 DMOTLN4 MN Proto-oncogene c-Met (MET) DMOTLN4 MT DTT DMOTLN4 MA Inhibitor DMOTLN4 RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMOTLN4 RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DMW1OKT DI DMW1OKT DMW1OKT DN CBT-501 DMW1OKT MI TTNBFWK DMW1OKT MN Programmed cell death protein 1 (PD-1) DMW1OKT MT DTT DMW1OKT MA Modulator DMW1OKT RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMW1OKT RU http://phrma-docs.phrma.org/files/dmfile/MID_Immuno-Oncology-2017_Drug-List1.pdf DM0SRAN DI DM0SRAN DM0SRAN DN CC-122 DM0SRAN MI TTDKGTC DM0SRAN MN Protein cereblon (CRBN) DM0SRAN MT DTT DM0SRAN MA Modulator DM0SRAN RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DM0SRAN RU http://phrma-docs.phrma.org/files/dmfile/MID_Neurological-Disorders-Drug-List_2018.pdf DMAYHT4 DI DMAYHT4 DMAYHT4 DN CC-31244 DMAYHT4 MI TTMVBWH DMAYHT4 MN Hepatitis C virus RNA-directed RNA polymerase (HCV NS5B) DMAYHT4 MT DTT DMAYHT4 MA Inhibitor DMAYHT4 RN Clinical pipeline report, company report or official report of Cocrystal Pharma. DMAYHT4 RU https://www.cocrystalpharma.com/development-pipeline/hepatitis-c/cc-31244 DMILHMC DI DMILHMC DMILHMC DN CC8464 DMILHMC MI TT4G2JS DMILHMC MN Voltage-gated sodium channel alpha Nav1.7 (SCN9A) DMILHMC MT DTT DMILHMC MA Inhibitor DMILHMC RN Antibodies and venom peptides: new modalities for ion channels. Nat Rev Drug Discov. 2019 May;18(5):339-357. DMILHMC RU https://pubmed.ncbi.nlm.nih.gov/30728472 DMXUT3Z DI DMXUT3Z DMXUT3Z DN CC-8490 DMXUT3Z MI TTZAYWL DMXUT3Z MN Estrogen receptor (ESR) DMXUT3Z MT DTT DMXUT3Z MA Modulator DMXUT3Z RN Agents with selective estrogen receptor (ER) modulator activity induce apoptosis in vitro and in vivo in ER-negative glioma cells. Cancer Res. 2004 Dec 15;64(24):9115-23. DMXUT3Z RU https://pubmed.ncbi.nlm.nih.gov/15604281 DMK0QDO DI DMK0QDO DMK0QDO DN CC-90002 DMK0QDO MI TT28S46 DMK0QDO MN Leukocyte surface antigen CD47 (CD47) DMK0QDO MT DTT DMK0QDO MA Inhibitor DMK0QDO RN National Cancer Institute Drug Dictionary (drug name CC 90002). DMK0QDO RU https://www.cancer.gov/publications/dictionaries/cancer-drug/def/anti-cd47-monoclonal-antibody-cc-90002 DMHJLB6 DI DMHJLB6 DMHJLB6 DN CC-90006 DMHJLB6 MI TTNBFWK DMHJLB6 MN Programmed cell death protein 1 (PD-1) DMHJLB6 MT DTT DMHJLB6 MA Antagonist DMHJLB6 RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMHJLB6 RU http://phrma-docs.phrma.org/files/dmfile/MID_Skin_Diseases_2018_9_FINAL.pdf DMKH3Z9 DI DMKH3Z9 DMKH3Z9 DN CC-90010 DMKH3Z9 MI TTE4BSY DMKH3Z9 MN Bromodomain and extraterminal domain protein (BET) DMKH3Z9 MT DTT DMKH3Z9 MA Inhibitor DMKH3Z9 RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMKH3Z9 RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DMO0AJE DI DMO0AJE DMO0AJE DN CC-90010 DMO0AJE MI TTE4BSY DMO0AJE MN Bromodomain and extraterminal domain protein (BET) DMO0AJE MT DTT DMO0AJE MA Inhibitor DMO0AJE RN Phase I study of CC-90010, a reversible, oral BET inhibitor in patients with advanced solid tumors and relapsed/refractory non-Hodgkin's lymphoma. Ann Oncol. 2020 Jun;31(6):780-788. DMO0AJE RU https://pubmed.ncbi.nlm.nih.gov/32240793 DM1GV6O DI DM1GV6O DM1GV6O DN CC-90011 DM1GV6O MI TTNR0UQ DM1GV6O MN Lysine-specific histone demethylase 1 (LSD) DM1GV6O MT DTT DM1GV6O MA Inhibitor DM1GV6O RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DM1GV6O RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DM1M4B8 DI DM1M4B8 DM1M4B8 DN CC-93269 DM1M4B8 MI TTZ3P4W DM1M4B8 MN B-cell maturation protein (TNFRSF17) DM1M4B8 MT DTT DM1M4B8 RN T-cell redirecting bispecific antibodies targeting BCMA for the treatment of multiple myeloma. Oncotarget. 2020 Nov 10;11(45):4076-4081. DM1M4B8 RU https://pubmed.ncbi.nlm.nih.gov/33227097 DM4581B DI DM4581B DM4581B DN CC-94676 DM4581B MI TTS64P2 DM4581B MN Androgen receptor (AR) DM4581B MT DTT DM4581B MA Degrader DM4581B RN ClinicalTrials.gov (NCT04428788) Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of CC-94676 in Subjects With Metastatic Castration-Resistant Prostate Cancer. U.S. National Institutes of Health. DM4581B RU https://clinicaltrials.gov/ct2/show/NCT04428788 DM7E1W0 DI DM7E1W0 DM7E1W0 DN CC-95251 DM7E1W0 MI TTBRJS9 DM7E1W0 MN Inhibitory receptor SHPS-1 (SIRPA) DM7E1W0 MT DTT DM7E1W0 RN ClinicalTrials.gov (NCT03783403) A Study of CC-95251, a Monoclonal Antibody Directed Against SIRPalpha, in Subjects With Advanced Solid and Hematologic Cancers. U.S. National Institutes of Health. DM7E1W0 RU https://clinicaltrials.gov/ct2/show/NCT03783403 DMJCIGN DI DMJCIGN DMJCIGN DN CC-95775 DMJCIGN MI TTE4BSY DMJCIGN MN Bromodomain and extraterminal domain protein (BET) DMJCIGN MT DTT DMJCIGN MA Inhibitor DMJCIGN RN Clinical pipeline report, company report or official report of Bristol-Myers Squibb. DMJCIGN RU https://www.bms.com/researchers-and-partners/in-the-pipeline.html DMLONJG DI DMLONJG DMLONJG DN CC-97540 DMLONJG MI TTW640A DMLONJG MN B-lymphocyte surface antigen B4 (CD19) DMLONJG MT DTT DMLONJG RN A Study of CC-97540, CD19-targeted NEX-T Chimeric Antigen Receptor (CAR) T Cells, in Subjects With Relapsed or Refractory B-cell Non-Hodgkin Lymphoma DMLONJG RU https://clinicaltrials.gov/ct2/show/NCT04231747 DM69YM1 DI DM69YM1 DM69YM1 DN CC-98633 DM69YM1 MI TTZ3P4W DM69YM1 MN B-cell maturation protein (TNFRSF17) DM69YM1 MT DTT DM69YM1 RN ClinicalTrials.gov (NCT04394650) A Study of CC-98633, BCMA-targeted Chimeric Antigen Receptor (CAR) T Cells, in Subjects With Relapsed and/or Refractory Multiple Myeloma. U.S. National Institutes of Health. DM69YM1 RU https://clinicaltrials.gov/ct2/show/NCT04394650 DM1UEBR DI DM1UEBR DM1UEBR DN CC-99712 DM1UEBR MI TTZ3P4W DM1UEBR MN B-cell maturation protein (TNFRSF17) DM1UEBR MT DTT DM1UEBR RN ClinicalTrials.gov (NCT04036461) A Study of CC-99712, a BCMA Antibody-Drug Conjugate, in Subjects With Relapsed and Refractory Multiple Myeloma. U.S. National Institutes of Health. DM1UEBR RU https://clinicaltrials.gov/ct2/show/NCT04036461 DM86CZJ DI DM86CZJ DM86CZJ DN C-CAR011 DM86CZJ MI TTW640A DM86CZJ MN B-lymphocyte surface antigen B4 (CD19) DM86CZJ MT DTT DM86CZJ MA CAR-T-Cell-Therapy DM86CZJ RN ClinicalTrials.gov (NCT03299738) A Study Evaluating Safety and Efficacy of C-CAR011 in Subjects With B-NHL DM86CZJ RU https://clinicaltrials.gov/ct2/show/NCT03299738 DMT35N2 DI DMT35N2 DMT35N2 DN C-CAR088 DMT35N2 MI TTZ3P4W DMT35N2 MN B-cell maturation protein (TNFRSF17) DMT35N2 MT DTT DMT35N2 MA CAR-T-Cell-Therapy DMT35N2 RN ClinicalTrials.gov (NCT03751293) A Study of BCMA-directed CAR-T Cells Treatment in Subjects With r/r Multiple Myeloma DMT35N2 RU https://clinicaltrials.gov/ct2/show/NCT03751293 DMCFMHR DI DMCFMHR DMCFMHR DN CCR5 mab DMCFMHR MI TT2CEJG DMCFMHR MN C-C chemokine receptor type 5 (CCR5) DMCFMHR MT DTT DMCFMHR RN CCR5 Monoclonal Antibodies for HIV-1 Therapy. Curr Opin HIV AIDS. 2009 March; 4(2): 104-111. DMCFMHR RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2760828/ DMPTYE6 DI DMPTYE6 DMPTYE6 DN CCW702 DMPTYE6 MI TT9G4N0 DMPTYE6 MN Glutamate carboxypeptidase II (GCPII) DMPTYE6 MT DTT DMPTYE6 RN Clinical pipeline report, company report or official report of AbbVie. DMPTYE6 RU https://www.abbvie.com/our-science/pipeline/ccw702.html DMPTYE6 DI DMPTYE6 DMPTYE6 DN CCW702 DMPTYE6 MI TTUN7MC DMPTYE6 MN T-cell surface glycoprotein CD3 (CD3) DMPTYE6 MT DTT DMPTYE6 RN Clinical pipeline report, company report or official report of AbbVie. DMPTYE6 RU https://www.abbvie.com/our-science/pipeline/ccw702.html DMCWVS7 DI DMCWVS7 DMCWVS7 DN CCX-025 DMCWVS7 MI TTIPS8B DMCWVS7 MN C-C chemokine receptor type 9 (CCR9) DMCWVS7 MT DTT DMCWVS7 MA Antagonist DMCWVS7 RN Targeting T-cell migration in inflammatory bowel disease. J Intern Med. 2012 Nov;272(5):411-29. DMCWVS7 RU https://pubmed.ncbi.nlm.nih.gov/22946654 DMO7TES DI DMO7TES DMO7TES DN CCX507 DMO7TES MI TTIPS8B DMO7TES MN C-C chemokine receptor type 9 (CCR9) DMO7TES MT DTT DMO7TES MA Antagonist DMO7TES RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMO7TES RU http://phrma-docs.phrma.org/files/dmfile/medicines-in-development-drug-list-autoimmune-diseases.pdf DM0XDYT DI DM0XDYT DM0XDYT DN CD10-CART DM0XDYT MI TT5TKPM DM0XDYT MN Neutral endopeptidase (MME) DM0XDYT MT DTT DM0XDYT MA CAR-T-Cell-Therapy(Dual specific) DM0XDYT RN ClinicalTrials.gov (NCT03407859) Sequential Treatment With CD20/CD22/CD10-CART After CD19-CART Treatment Base on MRD in Relapsed/Refractory B-ALL DM0XDYT RU https://clinicaltrials.gov/ct2/show/NCT03407859 DMDFY1R DI DMDFY1R DMDFY1R DN CD123CAR-41BB-CD3zeta-EGFRt-expressing T cells DMDFY1R MI TTENHJ0 DMDFY1R MN Interleukin 3 receptor alpha (IL3RA) DMDFY1R MT DTT DMDFY1R MA CAR-T-Cell-Therapy DMDFY1R RN ClinicalTrials.gov (NCT03114670) Donor-derived Anti-CD123-CART Cells for Recurred AML After Allo-HSCT DMDFY1R RU https://clinicaltrials.gov/ct2/show/NCT03114670 DMUJF9T DI DMUJF9T DMUJF9T DN CD123-CD33 Ccar DMUJF9T MI TTENHJ0 DMUJF9T MN Interleukin 3 receptor alpha (IL3RA) DMUJF9T MT DTT DMUJF9T RN Clinical pipeline report, company report or official report of iCell Gene Therapeutics. DMUJF9T RU http://icellgene.com/our-pipeline.html DMUJF9T DI DMUJF9T DMUJF9T DN CD123-CD33 Ccar DMUJF9T MI TTJVYO3 DMUJF9T MN Myeloid cell surface antigen CD33 (CD33) DMUJF9T MT DTT DMUJF9T RN Clinical pipeline report, company report or official report of iCell Gene Therapeutics. DMUJF9T RU http://icellgene.com/our-pipeline.html DM2AHXW DI DM2AHXW DM2AHXW DN CD171 specific CAR T cells expressing EGFRt DM2AHXW MI TTC9D3K DM2AHXW MN Neural cell adhesion molecule L1 (L1CAM) DM2AHXW MT DTT DM2AHXW MA CAR-T-Cell-Therapy DM2AHXW RN ClinicalTrials.gov (NCT02311621) Engineered Neuroblastoma Cellular Immunotherapy (ENCIT)-01 DM2AHXW RU https://clinicaltrials.gov/ct2/show/NCT02311621 DM4PWNU DI DM4PWNU DM4PWNU DN CD19 CAR T DM4PWNU MI TTW640A DM4PWNU MN B-lymphocyte surface antigen B4 (CD19) DM4PWNU MT DTT DM4PWNU MA CAR-T-Cell-Therapy DM4PWNU RN ClinicalTrials.gov (NCT03559439) CD19-targeting CAR T Cells in Relapsed or Refractory CD19 Positive B-cell Malignancies DM4PWNU RU https://clinicaltrials.gov/ct2/show/NCT03559439 DMCUBFR DI DMCUBFR DMCUBFR DN CD19 CAR T Cells DMCUBFR MI TTW640A DMCUBFR MN B-lymphocyte surface antigen B4 (CD19) DMCUBFR MT DTT DMCUBFR MA CAR-T-Cell-Therapy DMCUBFR RN ClinicalTrials.gov (NCT01853631) Activated T-Cells Expressing 2nd or 3rd Generation CD19-Specific CAR, Advanced B-Cell NHL, ALL, and CLL (SAGAN) DMCUBFR RU https://clinicaltrials.gov/ct2/show/NCT01853631 DMB8RI6 DI DMB8RI6 DMB8RI6 DN CD19 CAR T cells DMB8RI6 MI TTW640A DMB8RI6 MN B-lymphocyte surface antigen B4 (CD19) DMB8RI6 MT DTT DMB8RI6 MA CAR-T-Cell-Therapy DMB8RI6 RN ClinicalTrials.gov (NCT02975687) CD19 CAR T Cells in Patients With Resistant or Refractory CD19+ Acute Lymphoblastic Leukemia DMB8RI6 RU https://clinicaltrials.gov/ct2/show/NCT02975687 DMYFWQT DI DMYFWQT DMYFWQT DN CD19 CAR T-cells DMYFWQT MI TTW640A DMYFWQT MN B-lymphocyte surface antigen B4 (CD19) DMYFWQT MT DTT DMYFWQT MA CAR-T-Cell-Therapy DMYFWQT RN ClinicalTrials.gov (NCT03298828) CD19 CAR and PD-1 Knockout Engineered T Cells for CD19 Positive Malignant B-cell Derived Leukemia and Lymphoma DMYFWQT RU https://clinicaltrials.gov/ct2/show/NCT03298828 DMJCT6Q DI DMJCT6Q DMJCT6Q DN CD19 CAR T-cells DMJCT6Q MI TTW640A DMJCT6Q MN B-lymphocyte surface antigen B4 (CD19) DMJCT6Q MT DTT DMJCT6Q MA CAR-T-Cell-Therapy DMJCT6Q RN ClinicalTrials.gov (NCT02443831) CARPALL: Immunotherapy With CD19 CAR T-cells for CD19+ Haematological Malignancies DMJCT6Q RU https://clinicaltrials.gov/ct2/show/NCT02443831 DM6GNDP DI DM6GNDP DM6GNDP DN CD19 CAR-T cells DM6GNDP MI TTW640A DM6GNDP MN B-lymphocyte surface antigen B4 (CD19) DM6GNDP MT DTT DM6GNDP MA CAR-T-Cell-Therapy DM6GNDP RN ClinicalTrials.gov (NCT03671460) CD19 CAR-T Cells for Patients With Relapse and Refractory CD19+ B-ALL. DM6GNDP RU https://clinicaltrials.gov/ct2/show/NCT03671460 DMNDACU DI DMNDACU DMNDACU DN CD19 CAR-T cells DMNDACU MI TTW640A DMNDACU MN B-lymphocyte surface antigen B4 (CD19) DMNDACU MT DTT DMNDACU MA CAR-T-Cell-Therapy DMNDACU RN ClinicalTrials.gov (NCT03064269) CAR-T Therapy for Central Nervous System B-cell Acute Lymphocytic Leukemia DMNDACU RU https://clinicaltrials.gov/ct2/show/NCT03064269 DM49RAT DI DM49RAT DM49RAT DN CD19 Redirected Autologous T Cells DM49RAT MI TTW640A DM49RAT MN B-lymphocyte surface antigen B4 (CD19) DM49RAT MT DTT DM49RAT MA CAR-T-Cell-Therapy DM49RAT RN ClinicalTrials.gov (NCT03030976) A Study of CD19 Redirected Autologous T Cells for CD19 Positive Systemic Lupus Erythematosus (SLE) DM49RAT RU https://clinicaltrials.gov/ct2/show/NCT03030976 DMMO2EJ DI DMMO2EJ DMMO2EJ DN CD19.CAR-aNKT cells DMMO2EJ MI TTW640A DMMO2EJ MN B-lymphocyte surface antigen B4 (CD19) DMMO2EJ MT DTT DMMO2EJ MA CAR-T-Cell-Therapy DMMO2EJ RN ClinicalTrials.gov (NCT03774654) CD19.CAR Allogeneic NKT for Patients With Relapsed or Refractory B-Cell Malignancies (ANCHOR) DMMO2EJ RU https://clinicaltrials.gov/ct2/show/NCT03774654 DMVONF0 DI DMVONF0 DMVONF0 DN CD19/CD22 CAR T cells DMVONF0 MI TTM6QSK DMVONF0 MN B-cell receptor CD22 (CD22) DMVONF0 MT DTT DMVONF0 MA CAR-T-Cell-Therapy(Dual specific) DMVONF0 RN ClinicalTrials.gov (NCT03241940) CD19/CD22 Chimeric Antigen Receptor T Cells and Chemotherapy in Treating Children or Young Adults With Recurrent or Refractory CD19 Positive B Acute Lymphoblastic Leukemia DMVONF0 RU https://clinicaltrials.gov/ct2/show/NCT03241940 DMVONF0 DI DMVONF0 DMVONF0 DN CD19/CD22 CAR T cells DMVONF0 MI TTW640A DMVONF0 MN B-lymphocyte surface antigen B4 (CD19) DMVONF0 MT DTT DMVONF0 MA CAR-T-Cell-Therapy(Dual specific) DMVONF0 RN ClinicalTrials.gov (NCT03241940) CD19/CD22 Chimeric Antigen Receptor T Cells and Chemotherapy in Treating Children or Young Adults With Recurrent or Refractory CD19 Positive B Acute Lymphoblastic Leukemia DMVONF0 RU https://clinicaltrials.gov/ct2/show/NCT03241940 DMKA2FL DI DMKA2FL DMKA2FL DN CD19/CD22 CAR T-Cells DMKA2FL MI TTM6QSK DMKA2FL MN B-cell receptor CD22 (CD22) DMKA2FL MT DTT DMKA2FL MA CAR-T-Cell-Therapy(Dual specific) DMKA2FL RN ClinicalTrials.gov (NCT03448393) CD19/CD22 Chimeric Antigen Receptor (CAR) T Cells in Children and Young Adults With Recurrent or Refractory CD19/CD22-expressing B Cell Malignancies DMKA2FL RU https://clinicaltrials.gov/ct2/show/NCT03448393 DMKA2FL DI DMKA2FL DMKA2FL DN CD19/CD22 CAR T-Cells DMKA2FL MI TTW640A DMKA2FL MN B-lymphocyte surface antigen B4 (CD19) DMKA2FL MT DTT DMKA2FL MA CAR-T-Cell-Therapy(Dual specific) DMKA2FL RN ClinicalTrials.gov (NCT03448393) CD19/CD22 Chimeric Antigen Receptor (CAR) T Cells in Children and Young Adults With Recurrent or Refractory CD19/CD22-expressing B Cell Malignancies DMKA2FL RU https://clinicaltrials.gov/ct2/show/NCT03448393 DMPADR1 DI DMPADR1 DMPADR1 DN CD19/CD22 Chimeric Antigen Receptor T Cells DMPADR1 MI TTM6QSK DMPADR1 MN B-cell receptor CD22 (CD22) DMPADR1 MT DTT DMPADR1 MA CAR-T-Cell-Therapy(Dual specific) DMPADR1 RN ClinicalTrials.gov (NCT03233854) CD19/CD22 Chimeric Antigen Receptor T Cells and Chemotherapy in Treating Patients With Recurrent or Refractory CD19 Positive Diffuse Large B-Cell Lymphoma or B Acute Lymphoblastic Leukemia DMPADR1 RU https://clinicaltrials.gov/ct2/show/NCT03233854 DMPADR1 DI DMPADR1 DMPADR1 DN CD19/CD22 Chimeric Antigen Receptor T Cells DMPADR1 MI TTW640A DMPADR1 MN B-lymphocyte surface antigen B4 (CD19) DMPADR1 MT DTT DMPADR1 MA CAR-T-Cell-Therapy(Dual specific) DMPADR1 RN ClinicalTrials.gov (NCT03233854) CD19/CD22 Chimeric Antigen Receptor T Cells and Chemotherapy in Treating Patients With Recurrent or Refractory CD19 Positive Diffuse Large B-Cell Lymphoma or B Acute Lymphoblastic Leukemia DMPADR1 RU https://clinicaltrials.gov/ct2/show/NCT03233854 DMGUQ8V DI DMGUQ8V DMGUQ8V DN CD19+ CAR T Cells DMGUQ8V MI TTW640A DMGUQ8V MN B-lymphocyte surface antigen B4 (CD19) DMGUQ8V MT DTT DMGUQ8V MA CAR-T-Cell-Therapy DMGUQ8V RN ClinicalTrials.gov (NCT02529813) CD19+ CAR T Cells for Lymphoid Malignancies DMGUQ8V RU https://clinicaltrials.gov/ct2/show/NCT02529813 DMUR1MN DI DMUR1MN DMUR1MN DN CD19-CAR and CD28-CAR T Cells DMUR1MN MI TTW640A DMUR1MN MN B-lymphocyte surface antigen B4 (CD19) DMUR1MN MT DTT DMUR1MN MA CAR-T-Cell-Therapy(Dual specific) DMUR1MN RN ClinicalTrials.gov (NCT02146924) Cellular Immunotherapy in Treating Patients With High-Risk Acute Lymphoblastic Leukemia DMUR1MN RU https://clinicaltrials.gov/ct2/show/NCT02146924 DMUR1MN DI DMUR1MN DMUR1MN DN CD19-CAR and CD28-CAR T Cells DMUR1MN MI TTQ13FT DMUR1MN MN T-cell-specific surface glycoprotein CD28 (CD28) DMUR1MN MT DTT DMUR1MN MA CAR-T-Cell-Therapy(Dual specific) DMUR1MN RN ClinicalTrials.gov (NCT02146924) Cellular Immunotherapy in Treating Patients With High-Risk Acute Lymphoblastic Leukemia DMUR1MN RU https://clinicaltrials.gov/ct2/show/NCT02146924 DMJIW5Z DI DMJIW5Z DMJIW5Z DN CD19-CAR-T Cells DMJIW5Z MI TTW640A DMJIW5Z MN B-lymphocyte surface antigen B4 (CD19) DMJIW5Z MT DTT DMJIW5Z MA CAR-T-Cell-Therapy DMJIW5Z RN ClinicalTrials.gov (NCT03574168) CD19-CAR-T Cells in Patients With R/R B-ALL DMJIW5Z RU https://clinicaltrials.gov/ct2/show/NCT03574168 DML07UZ DI DML07UZ DML07UZ DN CD19-CAR-T2 Cells DML07UZ MI TTW640A DML07UZ MN B-lymphocyte surface antigen B4 (CD19) DML07UZ MT DTT DML07UZ MA CAR-T-Cell-Therapy DML07UZ RN ClinicalTrials.gov (NCT02822326) Phase I Study of CD19-CAR-T2 Cells for Patients With Chemotherapy Resistant or Refractory CD19+ Acute Leukemia DML07UZ RU https://clinicaltrials.gov/ct2/show/NCT02822326 DM3LRAF DI DM3LRAF DM3LRAF DN CD19CAT-41BBZ CAR T-cells DM3LRAF MI TTW640A DM3LRAF MN B-lymphocyte surface antigen B4 (CD19) DM3LRAF MT DTT DM3LRAF MA CAR-T-Cell-Therapy DM3LRAF RN ClinicalTrials.gov (NCT02935257) Immunotherapy for High Risk/Relapsed CD19+ Acute Lymphoblastic Leukaemia Using CAR T-cells to Target CD19 DM3LRAF RU https://clinicaltrials.gov/ct2/show/NCT02935257 DMETGAQ DI DMETGAQ DMETGAQ DN CD19-directed CAR-T cells DMETGAQ MI TTW640A DMETGAQ MN B-lymphocyte surface antigen B4 (CD19) DMETGAQ MT DTT DMETGAQ MA CAR-T-Cell-Therapy DMETGAQ RN ClinicalTrials.gov (NCT03463928) A Feasibility and Safety Study of Concomitant Therapy With Allo-CAR-T Cells and Allo-HSCT in Patients With Relapse or Refractory Leukemia DMETGAQ RU https://clinicaltrials.gov/ct2/show/NCT03463928 DM2OEQ9 DI DM2OEQ9 DM2OEQ9 DN CD19-directed CAR-T cells DM2OEQ9 MI TTW640A DM2OEQ9 MN B-lymphocyte surface antigen B4 (CD19) DM2OEQ9 MT DTT DM2OEQ9 MA CAR-T-Cell-Therapy DM2OEQ9 RN ClinicalTrials.gov (NCT03483688) A Phaseb Study Evaluating Safety and Efficacy of C-CAR011 Treatment in B- NHL Subjects DM2OEQ9 RU https://clinicaltrials.gov/ct2/show/NCT03483688 DMCZ3A2 DI DMCZ3A2 DMCZ3A2 DN CD19-targeted CART cells DMCZ3A2 MI TTW640A DMCZ3A2 MN B-lymphocyte surface antigen B4 (CD19) DMCZ3A2 MT DTT DMCZ3A2 MA CAR-T-Cell-Therapy DMCZ3A2 RN ClinicalTrials.gov (NCT03599375) Immunotherapy With CD19 CART-cells for B Cell Acute Lymphoblastic Leukemia DMCZ3A2 RU https://clinicaltrials.gov/ct2/show/NCT03599375 DMT7YOU DI DMT7YOU DMT7YOU DN CD19t-haNK DMT7YOU MI TTW640A DMT7YOU MN B-lymphocyte surface antigen B4 (CD19) DMT7YOU MT DTT DMT7YOU RN ClinicalTrials.gov (NCT04052061) QUILT 3.061: CD19 t-haNK in Subjects With Diffuse Large B-Cell Lymphoma. U.S. National Institutes of Health. DMT7YOU RU https://clinicaltrials.gov/ct2/show/NCT04052061 DMOHACZ DI DMOHACZ DMOHACZ DN CD19-TriCAR-T DMOHACZ MI TTW640A DMOHACZ MN B-lymphocyte surface antigen B4 (CD19) DMOHACZ MT DTT DMOHACZ MA CAR-T-Cell-Therapy DMOHACZ RN ClinicalTrials.gov (NCT03720496) Treatment of Refractory/Relapsed Non-Hodgkin Lymphoma With CD19-TriCAR-T Cell Therapy DMOHACZ RU https://clinicaltrials.gov/ct2/show/NCT03720496 DMGXS8L DI DMGXS8L DMGXS8L DN CD20Bi aATC DMGXS8L MI TTUE541 DMGXS8L MN Leukocyte surface antigen Leu-16 (CD20) DMGXS8L MT DTT DMGXS8L MA Modulator DMGXS8L RN CD20-Targeted T Cells after Stem Cell Transplantation for High Risk and Refractory Non-Hodgkin's Lymphoma. Biol Blood Marrow Transplant. 2013 June; 19(6): 925-933. DMGXS8L RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3794673/ DMGXS8L DI DMGXS8L DMGXS8L DN CD20Bi aATC DMGXS8L MI TTUN7MC DMGXS8L MN T-cell surface glycoprotein CD3 (CD3) DMGXS8L MT DTT DMGXS8L MA Modulator DMGXS8L RN CD20-Targeted T Cells after Stem Cell Transplantation for High Risk and Refractory Non-Hodgkin's Lymphoma. Biol Blood Marrow Transplant. 2013 June; 19(6): 925-933. DMGXS8L RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3794673/ DMSJBUZ DI DMSJBUZ DMSJBUZ DN CD20-CART DMSJBUZ MI TTUE541 DMSJBUZ MN Leukocyte surface antigen Leu-16 (CD20) DMSJBUZ MT DTT DMSJBUZ MA CAR-T-Cell-Therapy(Dual specific) DMSJBUZ RN ClinicalTrials.gov (NCT03407859) Sequential Treatment With CD20/CD22/CD10-CART After CD19-CART Treatment Base on MRD in Relapsed/Refractory B-ALL DMSJBUZ RU https://clinicaltrials.gov/ct2/show/NCT03407859 DM37OJN DI DM37OJN DM37OJN DN CD20-CAR-T Cells DM37OJN MI TTUE541 DM37OJN MN Leukocyte surface antigen Leu-16 (CD20) DM37OJN MT DTT DM37OJN MA CAR-T-Cell-Therapy DM37OJN RN ClinicalTrials.gov (NCT03576807) The Clinical Research of Anti-CD20 CAR-T Cells in Patients With Refractory or Relapsed B Lymphocyte Lymphoma DM37OJN RU https://clinicaltrials.gov/ct2/show/NCT03576807 DMUYTW3 DI DMUYTW3 DMUYTW3 DN CD20-CD19 cCAR DMUYTW3 MI TTW640A DMUYTW3 MN B-lymphocyte surface antigen B4 (CD19) DMUYTW3 MT DTT DMUYTW3 RN Clinical pipeline report, company report or official report of iCell Gene Therapeutics. DMUYTW3 RU http://icellgene.com/our-pipeline.html DMUYTW3 DI DMUYTW3 DMUYTW3 DN CD20-CD19 cCAR DMUYTW3 MI TTUE541 DMUYTW3 MN Leukocyte surface antigen Leu-16 (CD20) DMUYTW3 MT DTT DMUYTW3 RN Clinical pipeline report, company report or official report of iCell Gene Therapeutics. DMUYTW3 RU http://icellgene.com/our-pipeline.html DMHMPK1 DI DMHMPK1 DMHMPK1 DN CD22-CART DMHMPK1 MI TTM6QSK DMHMPK1 MN B-cell receptor CD22 (CD22) DMHMPK1 MT DTT DMHMPK1 MA CAR-T-Cell-Therapy(Dual specific) DMHMPK1 RN ClinicalTrials.gov (NCT03407859) Sequential Treatment With CD20/CD22/CD10-CART After CD19-CART Treatment Base on MRD in Relapsed/Refractory B-ALL DMHMPK1 RU https://clinicaltrials.gov/ct2/show/NCT03407859 DMP5V83 DI DMP5V83 DMP5V83 DN CD22-specific CAR T-cells also expressing an EGFRt DMP5V83 MI TTM6QSK DMP5V83 MN B-cell receptor CD22 (CD22) DMP5V83 MT DTT DMP5V83 MA CAR-T-Cell-Therapy DMP5V83 RN ClinicalTrials.gov (NCT03244306) A Phase 1 Study of CD22-CAR TCell Immunotherapy for CD22+ Leukemia and Lymphoma DMP5V83 RU https://clinicaltrials.gov/ct2/show/NCT03244306 DMFGQXB DI DMFGQXB DMFGQXB DN CD28 and CD137 CAR-T Cells DMFGQXB MI TTPW9LJ DMFGQXB MN Co-stimulatory molecule 4-1BB (CD137) DMFGQXB MT DTT DMFGQXB MA CAR-T-Cell-Therapy(Dual specific) DMFGQXB RN ClinicalTrials.gov (NCT02186860) Chimeric Antigen Receptor (CAR)-Modified T Cell Therapy in Treating Patients With Acute Lymphoblastic Leukemia DMFGQXB RU https://clinicaltrials.gov/ct2/show/NCT02186860 DMFGQXB DI DMFGQXB DMFGQXB DN CD28 and CD137 CAR-T Cells DMFGQXB MI TTQ13FT DMFGQXB MN T-cell-specific surface glycoprotein CD28 (CD28) DMFGQXB MT DTT DMFGQXB MA CAR-T-Cell-Therapy(Dual specific) DMFGQXB RN ClinicalTrials.gov (NCT02186860) Chimeric Antigen Receptor (CAR)-Modified T Cell Therapy in Treating Patients With Acute Lymphoblastic Leukemia DMFGQXB RU https://clinicaltrials.gov/ct2/show/NCT02186860 DM4VCJA DI DM4VCJA DM4VCJA DN CD30 CAR T Cells DM4VCJA MI TT2GM5R DM4VCJA MN Lymphocyte activation antigen CD30 (TNFRSF8) DM4VCJA MT DTT DM4VCJA MA CAR-T-Cell-Therapy DM4VCJA RN ClinicalTrials.gov (NCT02917083) CD30 CAR T Cells, Relapsed CD30 Expressing Lymphoma (RELY-30) DM4VCJA RU https://clinicaltrials.gov/ct2/show/NCT02917083 DMYD31U DI DMYD31U DMYD31U DN CD33-CAR-T Cell DMYD31U MI TTJVYO3 DMYD31U MN Myeloid cell surface antigen CD33 (CD33) DMYD31U MT DTT DMYD31U MA CAR-T-Cell-Therapy DMYD31U RN ClinicalTrials.gov (NCT03126864) Study of Adoptive Cellular Therapy Using Autologous T Cells Transduced With Lentivirus to Express a CD33 Specific Chimeric Antigen Receptor in Patients With Relapsed or Refractory CD33-Positive Acute Myeloid Leukemia DMYD31U RU https://clinicaltrials.gov/ct2/show/NCT03126864 DMNX0V7 DI DMNX0V7 DMNX0V7 DN CD38 CAR-T DMNX0V7 MI TTPURFN DMNX0V7 MN Cyclic ADP-ribose hydrolase 1 (CD38) DMNX0V7 MT DTT DMNX0V7 RN Clinical pipeline report, company report or official report of Sorrento Therapeutics. DMNX0V7 RU https://sorrentotherapeutics.com/research/pipeline/ DM09SW6 DI DM09SW6 DM09SW6 DN CD4CAR DM09SW6 MI TTN2JFW DM09SW6 MN T-cell surface glycoprotein CD4 (CD4) DM09SW6 MT DTT DM09SW6 RN Clinical pipeline report, company report or official report of iCell Gene Therapeutics. DM09SW6 RU https://icellgene.com/our-pipeline.html DMHTNLJ DI DMHTNLJ DMHTNLJ DN CD7.CAR/28zeta CAR T cells DMHTNLJ MI TTP6B8O DMHTNLJ MN T-cell antigen CD7 (CD7) DMHTNLJ MT DTT DMHTNLJ MA CAR-T-Cell-Therapy DMHTNLJ RN ClinicalTrials.gov (NCT03690011) Cell Therapy for High Risk T-Cell Malignancies Using CD7-Specific CAR Expressed On Autologous T Cells DMHTNLJ RU https://clinicaltrials.gov/ct2/show/NCT03690011 DM8DWOL DI DM8DWOL DM8DWOL DN CDNA vaccine DM8DWOL MI TTNYZG2 DM8DWOL MN Granulocyte-macrophage colony-stimulating factor (CSF2) DM8DWOL MT DTT DM8DWOL MA Modulator DM8DWOL RN Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41. DM8DWOL RU https://www.ncbi.nlm.nih.gov/pubmed/15950434 DMN8I5Q DI DMN8I5Q DMN8I5Q DN CDP-7657 DMN8I5Q MI TTIJP3Q DMN8I5Q MN TNF related activation protein (CD40LG) DMN8I5Q MT DTT DMN8I5Q RN CDP7657, an anti-CD40L antibody lacking an Fc domain, inhibits CD40L-dependent immune responses without thrombotic complications: an in vivo study. Arthritis Res Ther. 2015 Sep 3;17:234. DMN8I5Q RU https://pubmed.ncbi.nlm.nih.gov/26335795 DM049IX DI DM049IX DM049IX DN CDRI-97/78 DM049IX MI TTQ2GJ0 DM049IX MN Plasmodial phospholipid metabolism (PPP metab) DM049IX MT DTT DM049IX MA Modulator DM049IX RN Single Ascending Dose Safety and Pharmacokinetics of CDRI-97/78: First-in-Human Study of a Novel Antimalarial Drug. Malar Res Treat. 2014;2014:372521. DM049IX RU https://pubmed.ncbi.nlm.nih.gov/24800100 DMKUXB5 DI DMKUXB5 DMKUXB5 DN CDT-fenofibrate DMKUXB5 MI TTJ584C DMKUXB5 MN Peroxisome proliferator-activated receptor alpha (PPARA) DMKUXB5 MT DTT DMKUXB5 MA Agonist DMKUXB5 RN Mechanism of action of fibrates on lipid and lipoprotein metabolism. Circulation. 1998 Nov 10;98(19):2088-93. DMKUXB5 RU https://pubmed.ncbi.nlm.nih.gov/9808609 DMPVUGE DI DMPVUGE DMPVUGE DN CDX-1127 DMPVUGE MI TTDO1MV DMPVUGE MN T-cell activation antigen CD27 (CD27) DMPVUGE MT DTT DMPVUGE MA Modulator DMPVUGE RN Clinical pipeline report, company report or official report of Celldex Therapeutics. DMPVUGE RU http://www.celldex.com/pipeline/cdx-1127.php DMS20X6 DI DMS20X6 DMS20X6 DN CDX-1135 DMS20X6 MI TTEA8OW DMS20X6 MN Complement receptor type 1 (CR1) DMS20X6 MT DTT DMS20X6 MA Modulator DMS20X6 RN Complement activation is critical for placental ischemia-induced hypertension in the rat. Mol Immunol. 2013 Nov;56(1-2):91-7. DMS20X6 RU https://pubmed.ncbi.nlm.nih.gov/23685261 DMUGN0J DI DMUGN0J DMUGN0J DN CDX-1140 DMUGN0J MI TTN6Y9A DMUGN0J MN CD40L receptor (CD40) DMUGN0J MT DTT DMUGN0J MA Agonist DMUGN0J RN Development of CDX-1140, an agonist CD40 antibody for cancer immunotherapy. Cancer Immunol Immunother. 2019 Feb;68(2):233-245. DMUGN0J RU https://pubmed.ncbi.nlm.nih.gov/30382327 DMVDIWO DI DMVDIWO DMVDIWO DN CDX-527 DMVDIWO MI TTNBFWK DMVDIWO MN Programmed cell death protein 1 (PD-1) DMVDIWO MT DTT DMVDIWO MA Inhibitor DMVDIWO RN Development of CDX-527: a bispecific antibody combining PD-1 blockade and CD27 costimulation for cancer immunotherapy. Cancer Immunol Immunother. 2020 Oct;69(10):2125-2137. DMVDIWO RU https://pubmed.ncbi.nlm.nih.gov/32451681 DMVDIWO DI DMVDIWO DMVDIWO DN CDX-527 DMVDIWO MI TTDO1MV DMVDIWO MN T-cell activation antigen CD27 (CD27) DMVDIWO MT DTT DMVDIWO MA Activator DMVDIWO RN Development of CDX-527: a bispecific antibody combining PD-1 blockade and CD27 costimulation for cancer immunotherapy. Cancer Immunol Immunother. 2020 Oct;69(10):2125-2137. DMVDIWO RU https://pubmed.ncbi.nlm.nih.gov/32451681 DM45BHM DI DM45BHM DM45BHM DN CEA CAR-T DM45BHM MI TTY6DTE DM45BHM MN Carcinoembryonic antigen CEA (CD66e) DM45BHM MT DTT DM45BHM RN Clinical pipeline report, company report or official report of Sorrento Therapeutics. DM45BHM RU https://sorrentotherapeutics.com/research/immuno-oncology/car-t/ DMYDTJ6 DI DMYDTJ6 DMYDTJ6 DN CEP-11981 DMYDTJ6 MI TT9VGXW DMYDTJ6 MN Angiopoietin 1 receptor (TEK) DMYDTJ6 MT DTT DMYDTJ6 MA Modulator DMYDTJ6 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1842). DMYDTJ6 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1842 DMYDTJ6 DI DMYDTJ6 DMYDTJ6 DN CEP-11981 DMYDTJ6 MI TT2Q6G1 DMYDTJ6 MN Vascular endothelial growth factor receptor 1 (FLT-1) DMYDTJ6 MT DTT DMYDTJ6 MA Modulator DMYDTJ6 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 8189). DMYDTJ6 RU http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=8189 DMYDTJ6 DI DMYDTJ6 DMYDTJ6 DN CEP-11981 DMYDTJ6 MI TTUTJGQ DMYDTJ6 MN Vascular endothelial growth factor receptor 2 (KDR) DMYDTJ6 MT DTT DMYDTJ6 MA Inhibitor DMYDTJ6 RN A comparison of physicochemical property profiles of marketed oral drugs and orally bioavailable anti-cancer protein kinase inhibitors in clinical development. Curr Top Med Chem. 2007;7(14):1408-22. DMYDTJ6 RU https://pubmed.ncbi.nlm.nih.gov/17692029 DMYXQBF DI DMYXQBF DMYXQBF DN CEP-37251 DMYXQBF MI TT9E8HR DMYXQBF MN Osteoclast differentiation factor (ODF) DMYXQBF MT DTT DMYXQBF MA Inhibitor DMYXQBF RN This week in therapeutics Cancer. SciBX 3(40); doi:10.1038/scibx.2010.1202. Oct. 14, 2010 DMYXQBF RU http://www.nature.com/scibx/journal/v3/n40/pdf/scibx.2010.1202.pdf DMV632P DI DMV632P DMV632P DN CEP-37440 DMV632P MI TTON5IT DMV632P MN Focal adhesion kinase 1 (FAK) DMV632P MT DTT DMV632P MA Modulator DMV632P RN Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41. DMV632P RU https://www.ncbi.nlm.nih.gov/pubmed/15950434 DMLBKZV DI DMLBKZV DMLBKZV DN CER-002 DMLBKZV MI TT2JWF6 DMLBKZV MN Peroxisome proliferator-activated receptor delta (PPARD) DMLBKZV MT DTT DMLBKZV MA Agonist DMLBKZV RN Fibrates, glitazones, and peroxisome proliferator-activated receptors. Arterioscler Thromb Vasc Biol. 2010 May; 30(5): 894-899. DMLBKZV RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2997800/ DMGAW0H DI DMGAW0H DMGAW0H DN CER-522 DMGAW0H MI TT7GN3U DMGAW0H MN Apolipoprotein A-I (APOA1) DMGAW0H MT DTT DMGAW0H MA Modulator DMGAW0H RN Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800033541) DMGAW0H RU http://adisinsight.springer.com/drugs/800033541 DMH701Q DI DMH701Q DMH701Q DN CFI-402257 DMH701Q MI TTP7EGM DMH701Q MN Dual specificity protein kinase TTK (MPS1) DMH701Q MT DTT DMH701Q MA Inhibitor DMH701Q RN Functional characterization of CFI-402257, a potent and selective Mps1/TTK kinase inhibitor, for the treatment of cancer. Proc Natl Acad Sci U S A. 2017 Mar 21;114(12):3127-3132. DMH701Q RU https://pubmed.ncbi.nlm.nih.gov/28270606 DM3U2VY DI DM3U2VY DM3U2VY DN CG-200745 DM3U2VY MI TTBH0VX DM3U2VY MN Histone deacetylase (HDAC) DM3U2VY MT DTT DM3U2VY MA Inhibitor DM3U2VY RN Epigenetic modulation with HDAC inhibitor CG200745 induces anti-proliferation in non-small cell lung cancer cells. PLoS One. 2015 Mar 17;10(3):e0119379. DM3U2VY RU https://pubmed.ncbi.nlm.nih.gov/25781604 DMTCLM3 DI DMTCLM3 DMTCLM3 DN CGM097 DMTCLM3 MI TT7SBF5 DMTCLM3 MN Cellular tumor antigen p53 (TP53) DMTCLM3 MT DTT DMTCLM3 MA Modulator DMTCLM3 RN Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41. DMTCLM3 RU https://www.ncbi.nlm.nih.gov/pubmed/15950434 DMAY8I4 DI DMAY8I4 DMAY8I4 DN CGTG-102 DMAY8I4 MI TTNYZG2 DMAY8I4 MN Granulocyte-macrophage colony-stimulating factor (CSF2) DMAY8I4 MT DTT DMAY8I4 MA Modulator DMAY8I4 RN Serotype chimeric oncolytic adenovirus coding for GM-CSF for treatment of sarcoma in rodents and humans. Int J Cancer. 2014 Aug 1;135(3):720-30. DMAY8I4 RU https://pubmed.ncbi.nlm.nih.gov/24374597 DMSDNU1 DI DMSDNU1 DMSDNU1 DN CHF 5407 DMSDNU1 MI TTQ13Z5 DMSDNU1 MN Muscarinic acetylcholine receptor M3 (CHRM3) DMSDNU1 MT DTT DMSDNU1 MA Modulator DMSDNU1 RN Bronchodilator activity of (3R)-3-[[[(3-fluorophenyl)[(3,4,5-trifluorophenyl)methyl]amino] carbonyl]oxy]-1-[2-oxo-2-(2-thienyl)ethyl]-1-azoniabicyc... J Pharmacol Exp Ther. 2010 Dec;335(3):622-35. DMSDNU1 RU https://www.ncbi.nlm.nih.gov/pubmed/20805306 DMTE18G DI DMTE18G DMTE18G DN CHF-4227 DMTE18G MI TTZAYWL DMTE18G MN Estrogen receptor (ESR) DMTE18G MT DTT DMTE18G MA Modulator DMTE18G RN Pharmacological actions of a novel, potent, tissue-selective benzopyran estrogen. J Pharmacol Exp Ther. 2002 Oct;303(1):196-203. DMTE18G RU https://pubmed.ncbi.nlm.nih.gov/12235251 DMSOB5D DI DMSOB5D DMSOB5D DN Chi Lob 7/4 DMSOB5D MI TTIJP3Q DMSOB5D MN TNF related activation protein (CD40LG) DMSOB5D MT DTT DMSOB5D MA Modulator DMSOB5D RN Agonistic CD40 antibodies and cancer therapy DMSOB5D RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3590838 DM3L52Q DI DM3L52Q DM3L52Q DN Chlorcyclizine DM3L52Q MI DTSYQGK DM3L52Q MN Multidrug resistance-associated protein 1 (ABCC1) DM3L52Q MT DTP DM3L52Q MA Substrate DM3L52Q RN Carrier mediated transport of chlorpheniramine and chlorcyclizine across bovine olfactory mucosa: implications on nose-to-brain transport. J Pharm Sci. 2005 Mar;94(3):613-24. DM3L52Q RU http://www.ncbi.nlm.nih.gov/pubmed/15666293 DMJLZ8T DI DMJLZ8T DMJLZ8T DN CHT-25 DMJLZ8T MI TT10Y9E DMJLZ8T MN Interleukin 2 receptor alpha (IL2RA) DMJLZ8T MT DTT DMJLZ8T MA Modulator DMJLZ8T RN A Phase I Clinical Trial of CHT-25 a 131I-Labeled Chimeric Anti-CD25 Antibody Showing Efficacy in Patients with Refractory Lymphoma. Clin Cancer Res. 2009 Dec 15;15(24):7701-7710. DMJLZ8T RU https://pubmed.ncbi.nlm.nih.gov/20008855 DM2OB6S DI DM2OB6S DM2OB6S DN CI-8993 DM2OB6S MI TT51SK8 DM2OB6S MN V-set immunoregulatory receptor (VSIR) DM2OB6S MT DTT DM2OB6S MA Antagonist DM2OB6S RN Clinical pipeline report, company report or official report of Curis. DM2OB6S RU https://www.curis.com/pipeline/ci-8993/ DM6SCUK DI DM6SCUK DM6SCUK DN CI-959 DM6SCUK MI TT4IN7L DM6SCUK MN Histamine release (His rele) DM6SCUK MT DTT DM6SCUK MA Modulator DM6SCUK RN Cytoprotective effects of CI-959 in the rat gastric mucosa: modulation of leukocyte adhesion. Gastroenterology. 1995 Oct;109(4):1224-33. DM6SCUK RU https://pubmed.ncbi.nlm.nih.gov/7557089 DM8T2KA DI DM8T2KA DM8T2KA DN CI-966 DM8T2KA MI TTPRKM0 DM8T2KA MN GABA transporter GAT-1 (SLC6A1) DM8T2KA MT DTT DM8T2KA MA Modulator DM8T2KA RN Tiagabine, SK&F 89976-A, CI-966, and NNC-711 are selective for the cloned GABA transporter GAT-1. Eur J Pharmacol. 1994 Oct 14;269(2):219-24. DM8T2KA RU https://pubmed.ncbi.nlm.nih.gov/7851497 DMB2MKU DI DMB2MKU DMB2MKU DN CIGB-128 DMB2MKU MI TTSIUJ9 DMB2MKU MN Interferon-alpha 2 (IFNA2) DMB2MKU MT DTT DMB2MKU MA Modulator DMB2MKU RN Pharmacokinetic and pharmacodynamic characterization of a new formulation containing synergistic proportions of interferons alpha-2b and gamma (HeberPAG) in patients with mycosis fungoides: an open-label trial.BMC Pharmacol Toxicol.2012 Dec 28;13:20. DMB2MKU RU https://www.ncbi.nlm.nih.gov/pubmed/23272809 DMB2MKU DI DMB2MKU DMB2MKU DN CIGB-128 DMB2MKU MI TT93WF5 DMB2MKU MN Interferon-gamma (IFNG) DMB2MKU MT DTT DMB2MKU MA Modulator DMB2MKU RN Pharmacokinetic and pharmacodynamic characterization of a new formulation containing synergistic proportions of interferons alpha-2b and gamma (HeberPAG) in patients with mycosis fungoides: an open-label trial.BMC Pharmacol Toxicol.2012 Dec 28;13:20. DMB2MKU RU https://www.ncbi.nlm.nih.gov/pubmed/23272809 DMJFPK6 DI DMJFPK6 DMJFPK6 DN CIGB-228 DMJFPK6 MI TT3CPZW DMJFPK6 MN Human papillomavirus protein E7 (HPV E7) DMJFPK6 MT DTT DMJFPK6 RN Safety and Immunogenicity of a Human Papillomavirus Peptide Vaccine (CIGB-228) in Women with High-Grade Cervical Intraepithelial Neoplasia: First-in-Human, Proof-of-Concept Trial. ISRN Obstet Gynecol. 2011; 2011: 292951. DMJFPK6 RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3118643/ DM8XM72 DI DM8XM72 DM8XM72 DN CIGB-500 DM8XM72 MI TTSTYLU DM8XM72 MN Growth hormone secretion (GH secr) DM8XM72 MT DTT DM8XM72 MA Modulator DM8XM72 RN Growth hormone response in man to L-692,429, a novel nonpeptide mimic of growth hormone-releasing peptide-6. J Clin Endocrinol Metab. 1993 Nov;77(5):1393-7. DM8XM72 RU https://pubmed.ncbi.nlm.nih.gov/8077339 DMSGRA7 DI DMSGRA7 DMSGRA7 DN CIGB-M3 DMSGRA7 MI TTY6DTE DMSGRA7 MN Carcinoembryonic antigen CEA (CD66e) DMSGRA7 MT DTT DMSGRA7 RN Phase I clinical trial of the (131)I-labeled anticarcinoembryonic antigen CIGB-M3 multivalent antibody fragment. Cancer Biother Radiopharm. 2011 Jun;26(3):353-63. DMSGRA7 RU https://pubmed.ncbi.nlm.nih.gov/21711100 DM7EAG8 DI DM7EAG8 DM7EAG8 DN Cilobradine DM7EAG8 MI TTKLW9S DM7EAG8 MN Hyperpolarization cyclic nucleotide-gated channel (HCN) DM7EAG8 MT DTT DM7EAG8 MA Modulator DM7EAG8 RN Use-dependent blockade of cardiac pacemaker current (If) by cilobradine and zatebradine. Eur J Pharmacol. 2003 Oct 8;478(2-3):161-71. DM7EAG8 RU https://pubmed.ncbi.nlm.nih.gov/14575801 DMJLNEF DI DMJLNEF DMJLNEF DN Cipatinib DMJLNEF MI TTGKNB4 DMJLNEF MN Epidermal growth factor receptor (EGFR) DMJLNEF MT DTT DMJLNEF MA Modulator DMJLNEF RN Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41. DMJLNEF RU https://www.ncbi.nlm.nih.gov/pubmed/15950434 DMJLNEF DI DMJLNEF DMJLNEF DN Cipatinib DMJLNEF MI TT6EO5L DMJLNEF MN Erbb2 tyrosine kinase receptor (HER2) DMJLNEF MT DTT DMJLNEF MA Modulator DMJLNEF RN Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41. DMJLNEF RU https://www.ncbi.nlm.nih.gov/pubmed/15950434 DMQLODU DI DMQLODU DMQLODU DN Citarinostat DMQLODU MI TT5ZKDI DMQLODU MN Histone deacetylase 6 (HDAC6) DMQLODU MT DTT DMQLODU MA Inhibitor DMQLODU RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMQLODU RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DMRJF2Q DI DMRJF2Q DMRJF2Q DN Citatuzumab bogatox DMRJF2Q MI TTZ8WH4 DMRJF2Q MN Tumor-associated calcium signal transducer 1 (EPCAM) DMRJF2Q MT DTT DMRJF2Q RN Preclinical evaluation of VB6-845: an anti-EpCAM immunotoxin with reduced immunogenic potential. Cancer Biother Radiopharm. 2012 Nov;27(9):582-92. DMRJF2Q RU https://pubmed.ncbi.nlm.nih.gov/22856424 DMRQX9H DI DMRQX9H DMRQX9H DN CJ-12255 DMRQX9H MI TTZPO1L DMRQX9H MN Substance-P receptor (TACR1) DMRQX9H MT DTT DMRQX9H MA Antagonist DMRQX9H RN Neurokinin-1 receptor, a new modulator of lymphangiogenesis in obese-asthma phenotype. Life Sci. 2013 Aug 6;93(4):169-77. DMRQX9H RU https://pubmed.ncbi.nlm.nih.gov/23792204 DMGSEB0 DI DMGSEB0 DMGSEB0 DN CKD-516 DMGSEB0 MI TTYFKSZ DMGSEB0 MN Tubulin beta (TUBB) DMGSEB0 MT DTT DMGSEB0 MA Inhibitor DMGSEB0 RN CKD-516 displays vascular disrupting properties and enhances anti-tumor activity in combination with chemotherapy in a murine tumor model. Invest New Drugs. 2014 Jun;32(3):400-11. DMGSEB0 RU https://pubmed.ncbi.nlm.nih.gov/24202729 DMJX6SM DI DMJX6SM DMJX6SM DN CKD-712 DMJX6SM MI TTKAWRQ DMJX6SM MN JAK-STAT signaling pathway (JAK-STAT pathway) DMJX6SM MT DTT DMJX6SM MA Inhibitor DMJX6SM RN HO-1 and JAK-2/STAT-1 signals are involved in preferential inhibition of iNOS over COX-2 gene expression by newly synthesized tetrahydroisoquinoline alkaloid, CKD712, in cells activated with lipopolysacchride. Cell Signal. 2008 Oct;20(10):1839-47. DMJX6SM RU https://pubmed.ncbi.nlm.nih.gov/18634870 DM4UAPD DI DM4UAPD DM4UAPD DN Clemizole DM4UAPD MI DE4LYSA DM4UAPD MN Cytochrome P450 3A4 (CYP3A4) DM4UAPD MT DME DM4UAPD MA Metabolism DM4UAPD RN Using chimeric mice with humanized livers to predict human drug metabolism and a drug-drug interaction. J Pharmacol Exp Ther. 2013 Feb;344(2):388-96. DM4UAPD RU https://pubmed.ncbi.nlm.nih.gov/23143674 DM4UAPD DI DM4UAPD DM4UAPD DN Clemizole DM4UAPD MI TTALKDS DM4UAPD MN Hepatitis C virus Non-structural 4B (HCV NS4B) DM4UAPD MT DTT DM4UAPD MA Modulator DM4UAPD RN The hepatitis C virus (HCV) NS4B RNA binding inhibitor clemizole is highly synergistic with HCV protease inhibitors. J Infect Dis. 2010 Jul 1;202(1):65-74. DM4UAPD RU https://pubmed.ncbi.nlm.nih.gov/20486856 DM5EM04 DI DM5EM04 DM5EM04 DN CLL1-CD33 cCART cell therapy DM5EM04 MI TTJVYO3 DM5EM04 MN Myeloid cell surface antigen CD33 (CD33) DM5EM04 MT DTT DM5EM04 RN Clinical pipeline report, company report or official report of iCell Gene Therapeutics. DM5EM04 RU http://icellgene.com/our-pipeline.html DM5EM04 DI DM5EM04 DM5EM04 DN CLL1-CD33 cCART cell therapy DM5EM04 MI TT70N8V DM5EM04 MN Myeloid inhibitory C-type lectin-like receptor (CD371) DM5EM04 MT DTT DM5EM04 RN Clinical pipeline report, company report or official report of iCell Gene Therapeutics. DM5EM04 RU http://icellgene.com/our-pipeline.html DM05R4C DI DM05R4C DM05R4C DN CLN-081 DM05R4C MI TTGKNB4 DM05R4C MN Epidermal growth factor receptor (EGFR) DM05R4C MT DTT DM05R4C MA Inhibitor DM05R4C RN TAS6417, A Novel EGFR Inhibitor Targeting Exon 20 Insertion Mutations. Mol Cancer Ther. 2018 Aug;17(8):1648-1658. DM05R4C RU https://pubmed.ncbi.nlm.nih.gov/29748209 DM2QBMI DI DM2QBMI DM2QBMI DN CLP-1004 DM2QBMI MI TT1VOHK DM2QBMI MN Potassium channel unspecific (KC) DM2QBMI MT DTT DM2QBMI MA Binder DM2QBMI RN Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800036783) DM2QBMI RU http://adisinsight.springer.com/drugs/800036783 DM674MP DI DM674MP DM674MP DN CLT030 DM674MP MI TT70N8V DM674MP MN Myeloid inhibitory C-type lectin-like receptor (CD371) DM674MP MT DTT DM674MP RN Clinical pipeline report, company report or official report of Cellerant Therapeutics. DM674MP RU https://www.cellerant.com/programs/clt030/ DMJQG25 DI DMJQG25 DMJQG25 DN CLX-0921 DMJQG25 MI TTZMAO3 DMJQG25 MN Peroxisome proliferator-activated receptor gamma (PPAR-gamma) DMJQG25 MT DTT DMJQG25 MA Agonist DMJQG25 RN A novel peroxisome proliferator-activated gamma (PPAR gamma) agonist, CLX-0921, has potent antihyperglycemic activity with low adipogenic potential. Metabolism. 2003 Aug;52(8):1012-8. DMJQG25 RU https://pubmed.ncbi.nlm.nih.gov/12898466 DMMC6YR DI DMMC6YR DMMC6YR DN CM2489 DMMC6YR MI TT5HONZ DMMC6YR MN Calcium channel unspecific (CaC) DMMC6YR MT DTT DMMC6YR MA Modulator DMMC6YR RN Molecular pharmacology of store-operated CRAC channels DMMC6YR RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3913763 DMSJVX3 DI DMSJVX3 DMSJVX3 DN CM3.1-AC100 DMSJVX3 MI TTVIMDE DMSJVX3 MN Glucagon-like peptide 1 receptor (GLP1R) DMSJVX3 MT DTT DMSJVX3 MA Agonist DMSJVX3 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 249). DMSJVX3 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=249 DMY5V4U DI DMY5V4U DMY5V4U DN CM-CS1 T-cell DMY5V4U MI TTLRN4A DMY5V4U MN NKG2 D activating NK receptor (KLRK1) DMY5V4U MT DTT DMY5V4U MA CAR-T-Cell-Therapy DMY5V4U RN ClinicalTrials.gov (NCT02203825) Safety Study of Chimeric Antigen Receptor Modified T-cells Targeting NKG2D-Ligands DMY5V4U RU https://clinicaltrials.gov/ct2/show/NCT02203825 DMHBNKP DI DMHBNKP DMHBNKP DN C-Met/PD-L1 CAR-T Cell DMHBNKP MI TT8ZLTI DMHBNKP MN Programmed cell death 1 ligand 1 (PD-L1) DMHBNKP MT DTT DMHBNKP MA CAR-T-Cell-Therapy(Dual specific) DMHBNKP RN ClinicalTrials.gov (NCT03672305) Clinical Study on the Efficacy and Safety of c-Met/PD-L1 CAR-T Cell Injection in the Treatment of HCC DMHBNKP RU https://clinicaltrials.gov/ct2/show/NCT03672305 DMHBNKP DI DMHBNKP DMHBNKP DN C-Met/PD-L1 CAR-T Cell DMHBNKP MI TTNDSF4 DMHBNKP MN Proto-oncogene c-Met (MET) DMHBNKP MT DTT DMHBNKP MA CAR-T-Cell-Therapy(Dual specific) DMHBNKP RN ClinicalTrials.gov (NCT03672305) Clinical Study on the Efficacy and Safety of c-Met/PD-L1 CAR-T Cell Injection in the Treatment of HCC DMHBNKP RU https://clinicaltrials.gov/ct2/show/NCT03672305 DMGMI8P DI DMGMI8P DMGMI8P DN CMP-001 DMGMI8P MI TTSHG0T DMGMI8P MN Toll-like receptor 9 (TLR9) DMGMI8P MT DTT DMGMI8P MA Agonist DMGMI8P RN Clinical pipeline report, company report or official report of Checkmate Pharmaceuticals. DMGMI8P RU https://checkmatepharma.com/pipeline/ DM6NG3C DI DM6NG3C DM6NG3C DN CMV glycoprotein B subunit vaccine DM6NG3C MI TTUR18Y DM6NG3C MN Cytomegalovirus Glycoprotein B (CMV gB) DM6NG3C MT DTT DM6NG3C RN Clinical pipeline report, company report or official report of GlaxoSmithKline. DM6NG3C RU http://www.gsk-clinicalstudyregister.com/study/108890#ps DMMF0J3 DI DMMF0J3 DMMF0J3 DN CMX-157 DMMF0J3 MI TT84ETX DMMF0J3 MN Human immunodeficiency virus Reverse transcriptase (HIV RT) DMMF0J3 MT DTT DMMF0J3 MA Inhibitor DMMF0J3 RN Practical Considerations For Developing Nucleoside Reverse Transcriptase Inhibitors. Drug Discov Today Technol. 2012 Autumn; 9(3): e183-e193. DMMF0J3 RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3612025/ DM8L36X DI DM8L36X DM8L36X DN CNTO-3649 DM8L36X MI TTVIMDE DM8L36X MN Glucagon-like peptide 1 receptor (GLP1R) DM8L36X MT DTT DM8L36X MA Agonist DM8L36X RN GLP-1 receptor activation inhibits VLDL production and reverses hepatic steatosis by decreasing hepatic lipogenesis in high-fat-fed APOE*3-Leiden mice. PLoS One. 2012;7(11):e49152. DM8L36X RU https://pubmed.ncbi.nlm.nih.gov/23133675 DMF8WAT DI DMF8WAT DMF8WAT DN CNTO-5825 DMF8WAT MI TT0GVCH DMF8WAT MN Interleukin-13 (IL13) DMF8WAT MT DTT DMF8WAT RN Safety, tolerability and pharmacokinetics of a human anti-interleukin-13 monoclonal antibody (CNTO 5825) in an ascending single-dose first-in-human study. Br J Clin Pharmacol. 2013 May;75(5):1289-98. DMF8WAT RU https://pubmed.ncbi.nlm.nih.gov/23043368 DMUBP0V DI DMUBP0V DMUBP0V DN CNTO888 DMUBP0V MI TTNAY0P DMUBP0V MN Monocyte chemotactic and activating factor (CCL2) DMUBP0V MT DTT DMUBP0V RN CCL2 as an important mediator of prostate cancer growth in vivo through the regulation of macrophage infiltration. Neoplasia. 2007 Jul;9(7):556-62. DMUBP0V RU https://pubmed.ncbi.nlm.nih.gov/17710158 DMJPEVA DI DMJPEVA DMJPEVA DN CNTX-0290 DMJPEVA MI TTAE1BR DMJPEVA MN Somatostatin receptor type 4 (SSTR4) DMJPEVA MT DTT DMJPEVA MA Agonist DMJPEVA RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMJPEVA RU http://phrma-docs.phrma.org/files/dmfile/MID_Neurological-Disorders-Drug-List_2018.pdf DMCOJM7 DI DMCOJM7 DMCOJM7 DN CNTX-6970 DMCOJM7 MI TTFZYTO DMCOJM7 MN C-C chemokine receptor type 2 (CCR2) DMCOJM7 MT DTT DMCOJM7 MA Antagonist DMCOJM7 RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMCOJM7 RU http://phrma-docs.phrma.org/files/dmfile/MID_Neurological-Disorders-Drug-List_2018.pdf DMMEFO0 DI DMMEFO0 DMMEFO0 DN COH29 DMMEFO0 MI TTX09M4 DMMEFO0 MN Ribonucleotide reductase (RIR) DMMEFO0 MT DTT DMMEFO0 MA Inhibitor DMMEFO0 RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMMEFO0 RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DMXQOHV DI DMXQOHV DMXQOHV DN COM701 DMXQOHV MI TTOGCNT DMXQOHV MN Transmembrane protein PVRIG (PVRIG) DMXQOHV MT DTT DMXQOHV RN Clinical pipeline report, company report or official report of Compugen. DMXQOHV RU https://cgen.com/pipeline/com701-pvrig/ DMR6T8L DI DMR6T8L DMR6T8L DN COM902 DMR6T8L MI TTWNL74 DMR6T8L MN V-set and immunoglobulin domain-containing protein 9 (TIGIT) DMR6T8L MT DTT DMR6T8L RN COM902, a novel therapeutic antibody targeting TIGIT augments anti-tumor T cell function in combination with PVRIG or PD-1 pathway blockade. Cancer Immunol Immunother. 2021 Apr 26. DMR6T8L RU https://pubmed.ncbi.nlm.nih.gov/33903974 DMTLP1N DI DMTLP1N DMTLP1N DN Combinectin DMTLP1N MI TTG90S6 DMTLP1N MN Human immunodeficiency virus Glycoprotein 41 (HIV gp41) DMTLP1N MT DTT DMTLP1N MA Inhibitor DMTLP1N RN Clinical pipeline report, company report or official report of ViiV Healthcare. DMTLP1N RU https://jvi.asm.org/content/jvi/early/2019/07/25/JVI.00907-19.full.pdf DMTLP1N DI DMTLP1N DMTLP1N DN Combinectin DMTLP1N MI TTN2JFW DMTLP1N MN T-cell surface glycoprotein CD4 (CD4) DMTLP1N MT DTT DMTLP1N MA Inhibitor DMTLP1N RN Clinical pipeline report, company report or official report of ViiV Healthcare. DMTLP1N RU https://jvi.asm.org/content/jvi/early/2019/07/25/JVI.00907-19.full.pdf DMA7PWX DI DMA7PWX DMA7PWX DN Combotox DMA7PWX MI TTM6QSK DMA7PWX MN B-cell receptor CD22 (CD22) DMA7PWX MT DTT DMA7PWX MA Modulator DMA7PWX RN A phase I study of a combination of anti-CD19 and anti-CD22 immunotoxins (Combotox) in adult patients with refractory B-lineage acute lymphoblastic leukaemia.Br J Haematol.2011 Aug;154(4):471-6. DMA7PWX RU https://www.ncbi.nlm.nih.gov/pubmed/21732928 DMA7PWX DI DMA7PWX DMA7PWX DN Combotox DMA7PWX MI TTW640A DMA7PWX MN B-lymphocyte surface antigen B4 (CD19) DMA7PWX MT DTT DMA7PWX MA Modulator DMA7PWX RN A phase I study of a combination of anti-CD19 and anti-CD22 immunotoxins (Combotox) in adult patients with refractory B-lineage acute lymphoblastic leukaemia.Br J Haematol.2011 Aug;154(4):471-6. DMA7PWX RU https://www.ncbi.nlm.nih.gov/pubmed/21732928 DMULBZM DI DMULBZM DMULBZM DN Cosibelimab DMULBZM MI TT8ZLTI DMULBZM MN Programmed cell death 1 ligand 1 (PD-L1) DMULBZM MT DTT DMULBZM RN Phase 1 Study of CK-301 (Cosibelimab) as a Single Agent in Subjects With Advanced Cancers DMULBZM RU https://clinicaltrials.gov/ct2/show/NCT03212404 DM6K3JQ DI DM6K3JQ DM6K3JQ DN COTI-2 DM6K3JQ MI TT7SBF5 DM6K3JQ MN Cellular tumor antigen p53 (TP53) DM6K3JQ MT DTT DM6K3JQ MA Modulator DM6K3JQ RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DM6K3JQ RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DM32TFO DI DM32TFO DM32TFO DN CP-870,893 DM32TFO MI TTN6Y9A DM32TFO MN CD40L receptor (CD40) DM32TFO MT DTT DM32TFO MA Agonist DM32TFO RN Clinical activity and immune modulation in cancer patients treated with CP-870,893, a novel CD40 agonist monoclonal antibody. J Clin Oncol. 2007 Mar 1;25(7):876-83. DM32TFO RU https://pubmed.ncbi.nlm.nih.gov/17327609 DM3J1T9 DI DM3J1T9 DM3J1T9 DN CPC-212 DM3J1T9 MI TT1RS9F DM3J1T9 MN Acetylcholinesterase (AChE) DM3J1T9 MT DTT DM3J1T9 MA Inhibitor DM3J1T9 RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DM3J1T9 RU http://phrma-docs.phrma.org/files/dmfile/MID_Neurological-Disorders-Drug-List_2018.pdf DMDQG4Y DI DMDQG4Y DMDQG4Y DN CPC-250 DMDQG4Y MI TT1RS9F DMDQG4Y MN Acetylcholinesterase (AChE) DMDQG4Y MT DTT DMDQG4Y MA Inhibitor DMDQG4Y RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMDQG4Y RU http://phrma-docs.phrma.org/files/dmfile/MID_Neurological-Disorders-Drug-List_2018.pdf DMVDYTG DI DMVDYTG DMVDYTG DN CPG 52364 DMVDYTG MI TTRJ1K4 DMVDYTG MN Toll-like receptor 7 (TLR7) DMVDYTG MT DTT DMVDYTG MA Antagonist DMVDYTG RN Coley Pharmaceutical Group Diversifies Pipeline with First-in-Class TLR Antagonist for the Treatment of Systemic Lupus Erythematosus. Lupus Foundation of America, Inc. 2007. DMVDYTG RU http://www.lifesciencesworld.com/news/view/51194 DMVDYTG DI DMVDYTG DMVDYTG DN CPG 52364 DMVDYTG MI TT8CWFK DMVDYTG MN Toll-like receptor 8 (TLR8) DMVDYTG MT DTT DMVDYTG MA Antagonist DMVDYTG RN Coley Pharmaceutical Group Diversifies Pipeline with First-in-Class TLR Antagonist for the Treatment of Systemic Lupus Erythematosus. Lupus Foundation of America, Inc. 2007. DMVDYTG RU http://www.lifesciencesworld.com/news/view/51194 DMVDYTG DI DMVDYTG DMVDYTG DN CPG 52364 DMVDYTG MI TTSHG0T DMVDYTG MN Toll-like receptor 9 (TLR9) DMVDYTG MT DTT DMVDYTG MA Antagonist DMVDYTG RN Coley Pharmaceutical Group Diversifies Pipeline with First-in-Class TLR Antagonist for the Treatment of Systemic Lupus Erythematosus. Lupus Foundation of America, Inc. 2007. DMVDYTG RU http://www.lifesciencesworld.com/news/view/51194 DMJSFTX DI DMJSFTX DMJSFTX DN CPI-006 DMJSFTX MI TTK0O6Y DMJSFTX MN Ecto-5'-nucleotidase (CD73) DMJSFTX MT DTT DMJSFTX RN Clinical pipeline report, company report or official report of Corvus Pharmaceuticals. DMJSFTX RU https://www.corvuspharma.com/our-science/our-pipeline/ DMMBQ20 DI DMMBQ20 DMMBQ20 DN CPI-818 DMMBQ20 MI TT3C80U DMMBQ20 MN T-cell-specific kinase (ITK) DMMBQ20 MT DTT DMMBQ20 MA Inhibitor DMMBQ20 RN Clinical pipeline report, company report or official report of Corvus Pharmaceuticals. DMMBQ20 RU https://www.corvuspharma.com/our-science/our-pipeline/ DMFMGZR DI DMFMGZR DMFMGZR DN CPL207-280CA DMFMGZR MI TTB8FUC DMFMGZR MN Free fatty acid receptor 1 (GPR40) DMFMGZR MT DTT DMFMGZR MA Agonist DMFMGZR RN Targeting metabolic dysregulation for fibrosis therapy. Nat Rev Drug Discov. 2020 Jan;19(1):57-75. DMFMGZR RU https://pubmed.ncbi.nlm.nih.gov/31548636 DMQCHU3 DI DMQCHU3 DMQCHU3 DN CPP -15 DMQCHU3 MI TTT2LD9 DMQCHU3 MN GABA transaminase (ABAT) DMQCHU3 MT DTT DMQCHU3 MA Modulator DMQCHU3 RN Clinical pipeline report, company report or official report of Catalyst Pharma. DMQCHU3 RU http://ir.catalystpharma.com/releasedetail.cfm?ReleaseID=633588 DMKWSFI DI DMKWSFI DMKWSFI DN CR-002 DMKWSFI MI TTQA6SX DMKWSFI MN Platelet-derived growth factor B (PDGFB) DMKWSFI MT DTT DMKWSFI MA Modulator DMKWSFI RN A phase I study of CR002, a fully-human monoclonal antibody against platelet-derived growth factor-D. Int J Clin Pharmacol Ther. 2008 May;46(5):236-44. DMKWSFI RU https://www.ncbi.nlm.nih.gov/pubmed/18538109 DMT7L30 DI DMT7L30 DMT7L30 DN CR-3465 DMT7L30 MI TTGKOY9 DMT7L30 MN Leukotriene CysLT1 receptor (CYSLTR1) DMT7L30 MT DTT DMT7L30 MA Modulator DMT7L30 RN Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41. DMT7L30 RU https://www.ncbi.nlm.nih.gov/pubmed/15950434 DMHDSYF DI DMHDSYF DMHDSYF DN CRX-675 DMHDSYF MI TTISGCA DMHDSYF MN Toll-like receptor 4 (TLR4) DMHDSYF MT DTT DMHDSYF MA Agonist DMHDSYF RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1754). DMHDSYF RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1754 DMG0SPO DI DMG0SPO DMG0SPO DN CS-0777 DMG0SPO MI TT9JZCK DMG0SPO MN Sphingosine-1-phosphate receptor 1 (S1PR1) DMG0SPO MT DTT DMG0SPO MA Modulator DMG0SPO RN Discovery of CS-0777: A Potent, Selective, and Orally Active S1P1 Agonist. ACS Med Chem Lett. 2011 Mar 2;2(5):368-72. DMG0SPO RU https://pubmed.ncbi.nlm.nih.gov/24900318 DMU8OCN DI DMU8OCN DMU8OCN DN CS1-CAR T Therapy DMU8OCN MI TT7ILZ1 DMU8OCN MN SLAM family member 7 SLAMF7 (CS1) DMU8OCN MT DTT DMU8OCN MA CAR-T-Cell-Therapy DMU8OCN RN ClinicalTrials.gov (NCT03710421) CS1-CAR T Therapy Following Chemotherapy in Treating Patients With Relapsed or Refractory Multiple Myeloma DMU8OCN RU https://clinicaltrials.gov/ct2/show/NCT03710421 DMRH740 DI DMRH740 DMRH740 DN CS-8080 DMRH740 MI TTM1EQF DMRH740 MN Oxysterols receptor LXR (NR1H) DMRH740 MT DTT DMRH740 MA Modulator DMRH740 RN Liver X receptors in lipid metabolism: opportunities for drug discovery. Nat Rev Drug Discov. 2014 Jun;13(6):433-44. DMRH740 RU https://pubmed.ncbi.nlm.nih.gov/24833295 DMO97RV DI DMO97RV DMO97RV DN CSL-362 DMO97RV MI TTPYS82 DMO97RV MN Interleukin 3 receptor (CSF2RB) DMO97RV MT DTT DMO97RV RN Monoclonal antibody targeting of IL-3 receptor alpha with CSL362 effectively depletes CML progenitor and stem cells. Blood. 2014 Feb 20;123(8):1218-28. DMO97RV RU https://pubmed.ncbi.nlm.nih.gov/24363400 DM7I39W DI DM7I39W DM7I39W DN CSL-362-AML DM7I39W MI TTENHJ0 DM7I39W MN Interleukin 3 receptor alpha (IL3RA) DM7I39W MT DTT DM7I39W RN Monoclonal antibody targeting of IL-3 receptor alpha with CSL362 effectively depletes CML progenitor and stem cells. Blood. 2014 Feb 20;123(8):1218-28. DM7I39W RU https://pubmed.ncbi.nlm.nih.gov/24363400 DMI7XMU DI DMI7XMU DMI7XMU DN CT 868 DMI7XMU MI TTYMKBE DMI7XMU MN Gastric inhibitory polypeptide receptor (GIPR) DMI7XMU MT DTT DMI7XMU MA Modulator DMI7XMU RN Clinical pipeline report, company report or official report of Carmot Therapeutics. DMI7XMU RU http://carmot-therapeutics.us/pipeline/ DMI7XMU DI DMI7XMU DMI7XMU DN CT 868 DMI7XMU MI TTVIMDE DMI7XMU MN Glucagon-like peptide 1 receptor (GLP1R) DMI7XMU MT DTT DMI7XMU MA Modulator DMI7XMU RN Clinical pipeline report, company report or official report of Carmot Therapeutics. DMI7XMU RU http://carmot-therapeutics.us/pipeline/ DMBCJW6 DI DMBCJW6 DMBCJW6 DN CT053 DMBCJW6 MI TTZ3P4W DMBCJW6 MN B-cell maturation protein (TNFRSF17) DMBCJW6 MT DTT DMBCJW6 RN ClinicalTrials.gov (NCT03915184) Clinical Trial to Evaluate CT053 in Patients With Relapsed and/or Refractory Multiple Myeloma (LUMMICAR STUDY 2). U.S. National Institutes of Health. DMBCJW6 RU https://clinicaltrials.gov/ct2/show/NCT03915184 DMW16VR DI DMW16VR DMW16VR DN CT-200 DMW16VR MI TTBH0VX DMW16VR MN Histone deacetylase (HDAC) DMW16VR MT DTT DMW16VR MA Inhibitor DMW16VR RN Clinical pipeline report, company report or official report of Celleron. DMW16VR RU http://cellerontherapeutics.com/ DMHBK6L DI DMHBK6L DMHBK6L DN CTAP-201 DMHBK6L MI TTK59TV DMHBK6L MN Vitamin D3 receptor (VDR) DMHBK6L MT DTT DMHBK6L MA Agonist DMHBK6L RN Vascular calcification and secondary hyperparathyroidism of severe chronic kidney disease and its relation to serum phosphate and calcium levels. Br J Pharmacol. 2009 April; 156(8): 1267-1278. DMHBK6L RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2697742/ DM2HES0 DI DM2HES0 DM2HES0 DN CTCE-0214 DM2HES0 MI TTBID49 DM2HES0 MN C-X-C chemokine receptor type 4 (CXCR4) DM2HES0 MT DTT DM2HES0 MA Agonist DM2HES0 RN Beneficial effect of a CXCR4 agonist in murine models of systemic inflammation. Inflammation. 2012 Feb;35(1):130-7. DM2HES0 RU https://pubmed.ncbi.nlm.nih.gov/21274742 DMIKX01 DI DMIKX01 DMIKX01 DN CTP-298 DMIKX01 MI TT5FNQT DMIKX01 MN Human immunodeficiency virus Protease (HIV PR) DMIKX01 MT DTT DMIKX01 MA Inhibitor DMIKX01 RN Avanir Licenses Concert's Deuterium-Modified Dextromethorphan Products in Potential US$200 M Deal. Vol 2012 Issue 3 Page(38). DMIKX01 RU http://ojs.pharmadeals.net:5555/index.php/pdr/article/view/cr1696/html DM68I93 DI DM68I93 DM68I93 DN CTS-21166 DM68I93 MI TT8JRS7 DM68I93 MN Beta-secretase (BACE) DM68I93 MT DTT DM68I93 MA Inhibitor DM68I93 RN ClinicalTrials.gov (NCT00621010) Safety Study of CTS21166 to Treat Alzheimer Disease. U. S. National Institutes of Health. 2008. DM68I93 RU https://clinicaltrials.gov/ct2/show/NCT00621010 DMAV86R DI DMAV86R DMAV86R DN CTT1403 DMAV86R MI TT9G4N0 DMAV86R MN Glutamate carboxypeptidase II (GCPII) DMAV86R MT DTT DMAV86R MA Inhibitor DMAV86R RN 177 Lu-Labeled Phosphoramidate-Based PSMA Inhibitors: The Effect of an Albumin Binder on Biodistribution and Therapeutic Efficacy in Prostate Tumor-Bearing Mice. Theranostics. 2017 Apr 27;7(7):1928-1939. DMAV86R RU https://pubmed.ncbi.nlm.nih.gov/28638478 DMHK9WR DI DMHK9WR DMHK9WR DN CTX-101 DMHK9WR MI TTW640A DMHK9WR MN B-lymphocyte surface antigen B4 (CD19) DMHK9WR MT DTT DMHK9WR RN Off-the-shelf' allogeneic CAR T cells: development and challenges. Nat Rev Drug Discov. 2020 Mar;19(3):185-199. DMHK9WR RU https://pubmed.ncbi.nlm.nih.gov/31900462 DMWS40H DI DMWS40H DMWS40H DN CTX120 DMWS40H MI TTZ3P4W DMWS40H MN B-cell maturation protein (TNFRSF17) DMWS40H MT DTT DMWS40H RN Clinical pipeline report, company report or official report of CRISPR Therapeutics. DMWS40H RU http://www.crisprtx.com/programs/pipeline DM926CH DI DM926CH DM926CH DN CTX130 DM926CH MI TTNCIE0 DM926CH MN CD70 antigen (CD27-L) DM926CH MT DTT DM926CH RN Clinical pipeline report, company report or official report of CRISPR Therapeutics. DM926CH RU http://www.crisprtx.com/programs/pipeline DMMPKN3 DI DMMPKN3 DMMPKN3 DN CTX-471 DMMPKN3 MI TTPW9LJ DMMPKN3 MN Co-stimulatory molecule 4-1BB (CD137) DMMPKN3 MT DTT DMMPKN3 MA Agonist DMMPKN3 RN Clinical pipeline report, company report or official report of Compass Therapeutics. DMMPKN3 RU https://www.compasstherapeutics.com/candidates/ctx-471-cd137-agonist/ DM9ZOMD DI DM9ZOMD DM9ZOMD DN CUDC-101 DM9ZOMD MI TTGKNB4 DM9ZOMD MN Epidermal growth factor receptor (EGFR) DM9ZOMD MT DTT DM9ZOMD MA Modulator DM9ZOMD RN A Phase I Study of CUDC-101, a Multitarget Inhibitor of HDACs, EGFR, and HER2, in Combination with Chemoradiation in Patients with Head and Neck Squamous Cell Carcinoma. Clin Cancer Res. 2015 Apr 1;21(7):1566-73. DM9ZOMD RU https://pubmed.ncbi.nlm.nih.gov/25573383 DM9ZOMD DI DM9ZOMD DM9ZOMD DN CUDC-101 DM9ZOMD MI TT6EO5L DM9ZOMD MN Erbb2 tyrosine kinase receptor (HER2) DM9ZOMD MT DTT DM9ZOMD MA Modulator DM9ZOMD RN A Phase I Study of CUDC-101, a Multitarget Inhibitor of HDACs, EGFR, and HER2, in Combination with Chemoradiation in Patients with Head and Neck Squamous Cell Carcinoma. Clin Cancer Res. 2015 Apr 1;21(7):1566-73. DM9ZOMD RU https://pubmed.ncbi.nlm.nih.gov/25573383 DMYD37G DI DMYD37G DMYD37G DN CV8102 DMYD37G MI TTVB0O3 DMYD37G MN Retinoic acid-inducible gene-1 (RIG-1) DMYD37G MT DTT DMYD37G MA Agonist DMYD37G RN Clinical pipeline report, company report or official report of CureVac. DMYD37G RU https://www.curevac.com/en/pipeline/ DMYD37G DI DMYD37G DMYD37G DN CV8102 DMYD37G MI TTRJ1K4 DMYD37G MN Toll-like receptor 7 (TLR7) DMYD37G MT DTT DMYD37G MA Agonist DMYD37G RN Clinical pipeline report, company report or official report of CureVac. DMYD37G RU https://www.curevac.com/en/pipeline/ DMYD37G DI DMYD37G DMYD37G DN CV8102 DMYD37G MI TT8CWFK DMYD37G MN Toll-like receptor 8 (TLR8) DMYD37G MT DTT DMYD37G MA Agonist DMYD37G RN Clinical pipeline report, company report or official report of CureVac. DMYD37G RU https://www.curevac.com/en/pipeline/ DMTSIYZ DI DMTSIYZ DMTSIYZ DN CVN058 DMTSIYZ MI TTNXLKE DMTSIYZ MN 5-HT 3 receptor (5HT3R) DMTSIYZ MT DTT DMTSIYZ MA Antagonist DMTSIYZ RN Clinical pipeline report, company report or official report of Cerevance. DMTSIYZ RU https://cerevance.com/pipeline/ DMY84TW DI DMY84TW DMY84TW DN CVT-6883 DMY84TW MI TTNE7KG DMY84TW MN Adenosine A2b receptor (ADORA2B) DMY84TW MT DTT DMY84TW MA Modulator DMY84TW RN GS-6201, a selective blocker of the A2B adenosine receptor, attenuates cardiac remodeling after acute myocardial infarction in the mouse. J Pharmacol Exp Ther. 2012 Dec;343(3):587-95. DMY84TW RU https://pubmed.ncbi.nlm.nih.gov/22923737 DMO23R0 DI DMO23R0 DMO23R0 DN CVX 096 DMO23R0 MI TTVIMDE DMO23R0 MN Glucagon-like peptide 1 receptor (GLP1R) DMO23R0 MT DTT DMO23R0 MA Modulator DMO23R0 RN Chemically programmed antibodies. Trends Biotechnol. 2014 April; 32(4): 186-197. DMO23R0 RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3978777/ DMV74JC DI DMV74JC DMV74JC DN CVX-241 DMV74JC MI TTKLQTJ DMV74JC MN Angiopoietin-2 (ANGPT2) DMV74JC MT DTT DMV74JC MA Modulator DMV74JC RN Chemical generation of bispecific antibodies. Proc Natl Acad Sci U S A. 2010 December 28; 107(52): 22611-22616. DMV74JC RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3012461/ DMRD2B0 DI DMRD2B0 DMRD2B0 DN CXD-101 DMRD2B0 MI TTBH0VX DMRD2B0 MN Histone deacetylase (HDAC) DMRD2B0 MT DTT DMRD2B0 MA Inhibitor DMRD2B0 RN Activity of the new cephalosporin CXA-101 (FR264205) against Pseudomonas aeruginosa isolates from chronically-infected cystic fibrosis patients. Clin Microbiol Infect. 2010 Sep;16(9):1482-7. DMRD2B0 RU https://pubmed.ncbi.nlm.nih.gov/20002107 DM4GJ50 DI DM4GJ50 DM4GJ50 DN CXR-1002 DM4GJ50 MI TTTN5QW DM4GJ50 MN Serine/threonine-protein kinase pim-1 (PIM1) DM4GJ50 MT DTT DM4GJ50 MA Inhibitor DM4GJ50 RN 123 Antitumor activity of CXR1002, a novel anti-cancer clinical phase compound that induces ER stress and inhibits PIM kinases: Human tumor xenograft efficacy and in vitro mode of action. EJC Supplements, 2010; 8(7):45-46. DM4GJ50 RU http://www.researchgate.net/publication/251668212_123_Antitumor_activity_of_CXR1002_a_novel_anti-cancer_clinical_phase_compound_that_induces_ER_stress_and_inhibits_PIM_kinases_Human_tumor_xenograft_efficacy_and_in_vitro_mode_of_action DMSM42V DI DMSM42V DMSM42V DN CYAD-101 DMSM42V MI TTLRN4A DMSM42V MN NKG2 D activating NK receptor (KLRK1) DMSM42V MT DTT DMSM42V MA CAR-T-Cell-Therapy DMSM42V RN ClinicalTrials.gov (NCT03692429) alloSHRINK - Standard cHemotherapy Regimen and Immunotherapy With Allogeneic NKG2D-based CYAD-101 Chimeric Antigen Receptor T-cells DMSM42V RU https://clinicaltrials.gov/ct2/show/NCT03692429 DM9ODT6 DI DM9ODT6 DM9ODT6 DN CYC065 DM9ODT6 MI TT7HF4W DM9ODT6 MN Cyclin-dependent kinase 2 (CDK2) DM9ODT6 MT DTT DM9ODT6 MA Inhibitor DM9ODT6 RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DM9ODT6 RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DM9ODT6 DI DM9ODT6 DM9ODT6 DN CYC065 DM9ODT6 MI TT1LVF2 DM9ODT6 MN Cyclin-dependent kinase 9 (CDK9) DM9ODT6 MT DTT DM9ODT6 MA Inhibitor DM9ODT6 RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DM9ODT6 RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DMUMHXT DI DMUMHXT DMUMHXT DN CYC116 DMUMHXT MI TTPS3C0 DMUMHXT MN Aurora kinase A (AURKA) DMUMHXT MT DTT DMUMHXT MA Inhibitor DMUMHXT RN Clinical pipeline report, company report or official report of Cyclacel. DMUMHXT RU http://investor.cyclacel.com/releasedetail.cfm?ReleaseID=625011 DMUMHXT DI DMUMHXT DMUMHXT DN CYC116 DMUMHXT MI TT5LS6T DMUMHXT MN Aurora kinase B (AURKB) DMUMHXT MT DTT DMUMHXT MA Inhibitor DMUMHXT RN Clinical pipeline report, company report or official report of Cyclacel. DMUMHXT RU http://investor.cyclacel.com/releasedetail.cfm?ReleaseID=625011 DMUMHXT DI DMUMHXT DMUMHXT DN CYC116 DMUMHXT MI TTUTJGQ DMUMHXT MN Vascular endothelial growth factor receptor 2 (KDR) DMUMHXT MT DTT DMUMHXT MA Inhibitor DMUMHXT RN Clinical pipeline report, company report or official report of Cyclacel. DMUMHXT RU http://investor.cyclacel.com/releasedetail.cfm?ReleaseID=625011 DMC6PKJ DI DMC6PKJ DMC6PKJ DN CYC140 DMC6PKJ MI TTIYVQP DMC6PKJ MN Polo-like kinase 1 (PLK1) DMC6PKJ MT DTT DMC6PKJ MA Inhibitor DMC6PKJ RN Clinical pipeline report, company report or official report of Cyclacel Pharmaceuticals. DMC6PKJ RU https://cyclacel.com/research_programs_oncology_cyc140.shtml DMI6EUB DI DMI6EUB DMI6EUB DN Cyclolignan picropodophyllin DMI6EUB MI TTHRID2 DMI6EUB MN Insulin-like growth factor I receptor (IGF1R) DMI6EUB MT DTT DMI6EUB MA Inhibitor DMI6EUB RN The cyclolignan picropodophyllin attenuates intimal hyperplasia after rat carotid balloon injury by blocking insulin-like growth factor-1 receptor signaling. J Vasc Surg. 2007 Jul;46(1):108-15. DMI6EUB RU https://pubmed.ncbi.nlm.nih.gov/17606126 DMAWVTX DI DMAWVTX DMAWVTX DN Cyclopentenylcytosine DMAWVTX MI TTN12BZ DMAWVTX MN CTP synthase (CTPS1) DMAWVTX MT DTT DMAWVTX MA Inhibitor DMAWVTX RN Molecular approaches for the treatment of hemorrhagic fever virus infections. Antiviral Res. 1993 Sep;22(1):45-75. DMAWVTX RU https://pubmed.ncbi.nlm.nih.gov/8250543 DMNICD4 DI DMNICD4 DMNICD4 DN CYT-013-IL1bQb DMNICD4 MI TTRYK0X DMNICD4 MN Interleukin-1 beta (IL1B) DMNICD4 MT DTT DMNICD4 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2623). DMNICD4 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2623 DMTV09A DI DMTV09A DMTV09A DN Cyt-1010 DMTV09A MI TTKWM86 DMTV09A MN Opioid receptor mu (MOP) DMTV09A MT DTT DMTV09A MA Agonist DMTV09A RN Endomorphin-2: A Biased Agonist at the -Opioid Receptor. Mol Pharmacol. 2012 August; 82(2): 178-188. DMTV09A RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3400840/ DMJ83Z7 DI DMJ83Z7 DMJ83Z7 DN CYT-609 DMJ83Z7 MI TTF8CQI DMJ83Z7 MN Tumor necrosis factor (TNF) DMJ83Z7 MT DTT DMJ83Z7 MA Modulator DMJ83Z7 RN Phase I and Pharmacokinetic Studies of CYT-6091, a Novel PEGylated Colloidal Gold-rhTNF Nanomedicine. Clin Cancer Res. 2010 December 15; 16(24): 6139-6149. DMJ83Z7 RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3004980/ DMAY6X2 DI DMAY6X2 DMAY6X2 DN CZ-48 DMAY6X2 MI TTGTQHC DMAY6X2 MN DNA topoisomerase I (TOP1) DMAY6X2 MT DTT DMAY6X2 MA Inhibitor DMAY6X2 RN Pharmacology of camptothecin esters. Ann N Y Acad Sci. 2000;922:216-23. DMAY6X2 RU https://pubmed.ncbi.nlm.nih.gov/11193897 DMGA1DS DI DMGA1DS DMGA1DS DN D-0502 DMGA1DS MI TTZAYWL DMGA1DS MN Estrogen receptor (ESR) DMGA1DS MT DTT DMGA1DS MA Degrader DMGA1DS RN Clinical pipeline report, company report or official report of InventisBio. DMGA1DS RU http://www.inventisbio.com/en/product.html?id=1 DMTP9ER DI DMTP9ER DMTP9ER DN D-20133 DMTP9ER MI TT1UZQH DMTP9ER MN Phospholipase C (PLC) DMTP9ER MT DTT DMTP9ER MA Inhibitor DMTP9ER RN Novel Inhibitors of AKT: Assessment of a Different Approach Targeting the Pleckstrin Homology Domain. Curr Med Chem. 2011; 18(18): 2727-2742. DMTP9ER RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4091980/ DMIMK84 DI DMIMK84 DMIMK84 DN D2C7 DMIMK84 MI TTGKNB4 DMIMK84 MN Epidermal growth factor receptor (EGFR) DMIMK84 MT DTT DMIMK84 RN Improved efficacy against malignant brain tumors with EGFRwt/EGFRvIII targeting immunotoxin and checkpoint inhibitor combinations. J Immunother Cancer. 2019 May 29;7(1):142. DMIMK84 RU https://pubmed.ncbi.nlm.nih.gov/31142380 DMIMK84 DI DMIMK84 DMIMK84 DN D2C7 DMIMK84 MI TTZ6B2I DMIMK84 MN Epidermal growth factor receptor variant III (EGFR vIII) DMIMK84 MT DTT DMIMK84 RN Improved efficacy against malignant brain tumors with EGFRwt/EGFRvIII targeting immunotoxin and checkpoint inhibitor combinations. J Immunother Cancer. 2019 May 29;7(1):142. DMIMK84 RU https://pubmed.ncbi.nlm.nih.gov/31142380 DM7V2OM DI DM7V2OM DM7V2OM DN D-3263 DM7V2OM MI TTXDKTO DM7V2OM MN Long transient receptor potential channel 8 (TRPM8) DM7V2OM MT DTT DM7V2OM MA Modulator DM7V2OM RN Best of the 2009 AUA Annual Meeting: Highlights from the 2009 Annual Meeting of the American Urological Association, April 25-30, 2009, Chicago, IL. Rev Urol. 2009 Spring; 11(2): 82-107. DM7V2OM RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2725309/ DM4OTWL DI DM4OTWL DM4OTWL DN DA-1229 DM4OTWL MI TTDIGC1 DM4OTWL MN Dipeptidyl peptidase 4 (DPP-4) DM4OTWL MT DTT DM4OTWL MA Inhibitor DM4OTWL RN DA-1229, a novel and potent DPP4 inhibitor, improves insulin resistance and delays the onset of diabetes. Life Sci. 2012 Jan 2;90(1-2):21-9. DM4OTWL RU https://pubmed.ncbi.nlm.nih.gov/22056373 DMPJA64 DI DMPJA64 DMPJA64 DN DA-1241 DMPJA64 MI TT7QNVC DMPJA64 MN Glucose-dependent insulinotropic receptor (GPR119) DMPJA64 MT DTT DMPJA64 MA Agonist DMPJA64 RN ClinicalTrials.gov (NCT03646721) A Study to Evaluate the Safety, Tolerability, PK and PD of DA-1241 in Healthy Male Subjects and Subjects With T2DM. U.S. National Institutes of Health. DMPJA64 RU https://clinicaltrials.gov/ct2/show/NCT03646721 DM4JG0B DI DM4JG0B DM4JG0B DN DA-3607 DM4JG0B MI TTA5MS9 DM4JG0B MN TNF related apoptosis inducing ligand (TNFSF10) DM4JG0B MT DTT DM4JG0B MA Binder DM4JG0B RN Cancer gene therapy using a novel secretable trimeric TRAIL. Gene Ther. 2006 Feb;13(4):330-8. DM4JG0B RU https://pubmed.ncbi.nlm.nih.gov/16195699 DMKPAOD DI DMKPAOD DMKPAOD DN DA-6886 DMKPAOD MI TT07C3Y DMKPAOD MN 5-HT 4 receptor (HTR4) DMKPAOD MT DTT DMKPAOD MA Agonist DMKPAOD RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 9). DMKPAOD RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=9 DMBRN2G DI DMBRN2G DMBRN2G DN DA-697b DMBRN2G MI TT3SZBT DMBRN2G MN von Willebrand factor (VWF) DMBRN2G MT DTT DMBRN2G MA Inhibitor DMBRN2G RN A new oral antiplatelet agent with potent antithrombotic properties: comparison of DZ-697b with clopidogrel a randomised phase I study. Thromb Haemost. 2010 Jan;103(1):205-12. DMBRN2G RU https://pubmed.ncbi.nlm.nih.gov/20062928 DM9KS1A DI DM9KS1A DM9KS1A DN DA-727 DM9KS1A MI TTGN1ZA DM9KS1A MN Angiotensin II receptor (AGTR) DM9KS1A MT DTT DM9KS1A MA Modulator DM9KS1A RN WO patent application no. 2009,0880,06, Combined pharmaceutical agent. DM9KS1A RU http://worldwide.espacenet.com/publicationDetails/biblio?DB=worldwide.espacenet.com&II=0&ND=3&adjacent=true&locale=en_EP&FT=D&date=20090716&CC=WO&NR=2009088006A1&KC=A1 DMQR4HA DI DMQR4HA DMQR4HA DN DABIS MALEATE DMQR4HA MI TTUTN1I DMQR4HA MN Human Deoxyribonucleic acid (hDNA) DMQR4HA MT DTT DMQR4HA MA Binder DMQR4HA RN DNA damage and sequence specificity of DNA binding of the new anti-cancer agent 1,4-bis(2'-chloroethyl)-1,4-diazabicyclo-[2.2.1] heptane dimaleate (Dabis maleate)Broggini M1, Hartley JA, Mattes WB, Ponti M, Kohn KW, D'Incalci M.Author information1Laboratory of Cancer Chemotherapy, Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy.Erratum inBr J Cancer 1990 Jul;62(1):172. AbstractThe DNA damage and the sequence specificity of guanine-N7 alkylation produced by the novel, positively charged, antineoplastic agent 1,4-bis(2'-chloroethyl)-1,4-diazabicyclo-[2.2.1] heptane dimaleate (Dabis maleate) and its uncharged tertiary amine analogue 1,4-bis(2'-chloroethyl)-1,4-diazacyclohexane (Dabis analogue) were investigated in L1210 cells and isolated DNA. Both compounds are cytotoxic in vitro causing an arrest of L1210 cells in G2/M phase of the cell cycle. In isolated DNA, Dabis maleate alkylates guanine at the N7-position with some differences in specificity compared to other alkylating agents (e.g. nitrogen mustard). Significant differences are also evident between Dabis maleate and Dabis analogue, suggesting that Dabis analogue is not the sole alkylating species of Dabis maleate. Using the alkaline elution technique a moderate number of DNA interstrand cross-links were detected in L1210 cells treated with both compounds, which were completely repaired within 24 h. Dabis maleate and Dabis analogue do not cause DNA single strand breaks or DNA protein cross-links at the doses at which DNA interstrand cross-links were detected.PMID: 2393411 [PubMed - indexed for MEDLINE] PMCID: PMC1971404 Free PMC ArticleSharePublication Types, MeSH Terms, SubstancesPublication TypesResearch Support, Non-U.S. Gov'tMeSH TermsAnimalsAntineoplastic Agents/pharmacology*Base SequenceBicycloCompounds/pharmacology*Bicyclo Compounds, Heterocyclic*Bridged Compounds/pharmacology*Cell Survival/drug effectsDNA Damage*DNA, Neoplasm/drug effects*Dose-Response Relationship, DrugHumansInterphase/drug effectsLeukemia L1210/pathologyTumor Cells, Cultured/drug effectsSubstancesAntineoplastic AgentsBicyclo CompoundsBicyclo Compounds, HeterocyclicBridged CompoundsDNA, Neoplasm1,4-bis(2'-chloroethyl)-1,4-diazabicyclo(2.2.1)heptaneLinkOut - more resourcesFull Text SourcesEurope PubMed CentralPubMed CentralPubMed Central CanadaOther Literature SourcesCOS Scholar UniverseAccess more work from the authors - ResearchGateMiscellaneousNCI CPTAC Assay PortalPubMed Commons home Br J Cancer. 1990 Feb;61(2):285-9. DMQR4HA RU https://pubmed.ncbi.nlm.nih.gov/2393411 DM5TB76 DI DM5TB76 DM5TB76 DN DACRA 089 DM5TB76 MI TTAT87F DM5TB76 MN Amylin receptor (IAPPR) DM5TB76 MT DTT DM5TB76 MA Agonist DM5TB76 RN A novel dual amylin and calcitonin receptor agonist, KBP-089, induces weight loss through a reduction in fat, but not lean mass, while improving food preference. Br J Pharmacol. 2017 Apr;174(7):591-602. DM5TB76 RU https://pubmed.ncbi.nlm.nih.gov/28109166 DM5TB76 DI DM5TB76 DM5TB76 DN DACRA 089 DM5TB76 MI TTLWS2O DM5TB76 MN Calcitonin receptor (CALCR) DM5TB76 MT DTT DM5TB76 MA Agonist DM5TB76 RN A novel dual amylin and calcitonin receptor agonist, KBP-089, induces weight loss through a reduction in fat, but not lean mass, while improving food preference. Br J Pharmacol. 2017 Apr;174(7):591-602. DM5TB76 RU https://pubmed.ncbi.nlm.nih.gov/28109166 DMWT5RS DI DMWT5RS DMWT5RS DN Daniquidone DMWT5RS MI TTGTQHC DMWT5RS MN DNA topoisomerase I (TOP1) DMWT5RS MT DTT DMWT5RS MA Modulator DMWT5RS RN Pharmacogenetically driven patient selection for a first-in-human phase I trial of batracylin in patients with advanced solid tumors and lymphomas.Cancer Chemother Pharmacol.2013 Oct;72(4):917-23. DMWT5RS RU https://www.ncbi.nlm.nih.gov/pubmed/23912694 DMWT5RS DI DMWT5RS DMWT5RS DN Daniquidone DMWT5RS MI TT0IHXV DMWT5RS MN DNA topoisomerase II (TOP2) DMWT5RS MT DTT DMWT5RS MA Modulator DMWT5RS RN Pharmacogenetically driven patient selection for a first-in-human phase I trial of batracylin in patients with advanced solid tumors and lymphomas.Cancer Chemother Pharmacol.2013 Oct;72(4):917-23. DMWT5RS RU https://www.ncbi.nlm.nih.gov/pubmed/23912694 DM4A3U7 DI DM4A3U7 DM4A3U7 DN DAVLB-HYDRAZIDE DM4A3U7 MI TTYFKSZ DM4A3U7 MN Tubulin beta (TUBB) DM4A3U7 MT DTT DM4A3U7 MA Modulator DM4A3U7 RN An Overview of Tubulin Inhibitors That Interact with the Colchicine Binding Site. Pharm Res. 2012 November; 29(11): 2943-2971. DM4A3U7 RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3667160/ DM1K248 DI DM1K248 DM1K248 DN DB-053072 DM1K248 MI DEBTUZ3 DM1K248 MN D-Lactate dehydrogenase (ldhA) DM1K248 MT DME DM1K248 MA Metabolism DM1K248 RN Diverse allosteric and catalytic functions of tetrameric d-lactate dehydrogenases from three Gram-negative bacteria. AMB Express. 2014 Oct 28;4:76. DM1K248 RU https://pubmed.ncbi.nlm.nih.gov/25401076 DM1K248 DI DM1K248 DM1K248 DN DB-053072 DM1K248 MI DEHUP0C DM1K248 MN D-Lactate dehydrogenase (ldhA) DM1K248 MT DME DM1K248 MA Metabolism DM1K248 RN Cloning of D-lactate dehydrogenase genes of Lactobacillus delbrueckii subsp. bulgaricus and their roles in D-lactic acid production. 3 Biotech. 2017 Jul;7(3):194. DM1K248 RU https://pubmed.ncbi.nlm.nih.gov/28664378 DM1K248 DI DM1K248 DM1K248 DN DB-053072 DM1K248 MI DECY6JG DM1K248 MN D-Lactate dehydrogenase (ldhA) DM1K248 MT DME DM1K248 MA Metabolism DM1K248 RN Diverse allosteric and catalytic functions of tetrameric d-lactate dehydrogenases from three Gram-negative bacteria. AMB Express. 2014 Oct 28;4:76. DM1K248 RU https://pubmed.ncbi.nlm.nih.gov/25401076 DM1K248 DI DM1K248 DM1K248 DN DB-053072 DM1K248 MI DEJEWXB DM1K248 MN D-Lactate dehydrogenase (ldhA) DM1K248 MT DME DM1K248 MA Metabolism DM1K248 RN Diverse allosteric and catalytic functions of tetrameric d-lactate dehydrogenases from three Gram-negative bacteria. AMB Express. 2014 Oct 28;4:76. DM1K248 RU https://pubmed.ncbi.nlm.nih.gov/25401076 DM1K248 DI DM1K248 DM1K248 DN DB-053072 DM1K248 MI DESR17C DM1K248 MN L-Lactate dehydrogenase (ldh) DM1K248 MT DME DM1K248 MA Metabolism DM1K248 RN Purification, properties and immunological relationship of L (+)-lactate dehydrogenase from Lactobacillus casei. Eur J Biochem. 1976 Aug 16;67(2):543-55. DM1K248 RU https://pubmed.ncbi.nlm.nih.gov/823016 DM1K248 DI DM1K248 DM1K248 DN DB-053072 DM1K248 MI DE5DTYB DM1K248 MN L-Lactate dehydrogenase (ldh) DM1K248 MT DME DM1K248 MA Metabolism DM1K248 RN Positive selection on D-lactate dehydrogenases of Lactobacillus delbrueckii subspecies bulgaricus. IET Syst Biol. 2015 Aug;9(4):172-9. DM1K248 RU https://pubmed.ncbi.nlm.nih.gov/26243834 DM1K248 DI DM1K248 DM1K248 DN DB-053072 DM1K248 MI DE6QXYP DM1K248 MN Pyruvate oxidase (pyrO) DM1K248 MT DME DM1K248 MA Metabolism DM1K248 RN Metabolic gene-targeted monitoring of non-starter lactic acid bacteria during cheese ripening. Int J Food Microbiol. 2017 Sep 18;257:276-284. DM1K248 RU https://pubmed.ncbi.nlm.nih.gov/28735145 DM6K47B DI DM6K47B DM6K47B DN DC/I540/KLH vaccine DM6K47B MI TTUJFD0 DM6K47B MN Telomerase reverse transcriptase (TERT) DM6K47B MT DTT DM6K47B RN Vaccination of cancer patients against telomerase induces functional antitumor CD8+ T lymphocytes. Clin Cancer Res. 2004 Feb 1;10(3):828-39. DM6K47B RU https://pubmed.ncbi.nlm.nih.gov/14871958 DMLVG9D DI DMLVG9D DMLVG9D DN DCC-3014 DMLVG9D MI TT7MRDV DMLVG9D MN Macrophage colony-stimulating factor 1 receptor (CSF1R) DMLVG9D MT DTT DMLVG9D MA Inhibitor DMLVG9D RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMLVG9D RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DMQ8ACY DI DMQ8ACY DMQ8ACY DN DCCCyB DMQ8ACY MI TTHJTF7 DMQ8ACY MN Glycine transporter GlyT-1 (SLC6A9) DMQ8ACY MT DTT DMQ8ACY MA Modulator DMQ8ACY RN Identification of an Orally Bioavailable, Potent, and Selective Inhibitor of GlyT1. ACS Med Chem Lett. 2010 October 14; 1(7): 350-354. DMQ8ACY RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4007840/ DMQIEFB DI DMQIEFB DMQIEFB DN Debio 0827 DMQIEFB MI TT5TKPM DMQIEFB MN Neutral endopeptidase (MME) DMQIEFB MT DTT DMQIEFB MA Inhibitor DMQIEFB RN Clinical pipeline report, company report or official report of Debiopharm (2011). DMQIEFB RU http://www.debiopharm.com/our-business/pipeline.html DMWP3G1 DI DMWP3G1 DMWP3G1 DN Debio 0932 DMWP3G1 MI TT78R5H DMWP3G1 MN Heat shock protein 90 alpha (HSP90A) DMWP3G1 MT DTT DMWP3G1 MA Inhibitor DMWP3G1 RN Clinical pipeline report, company report or official report of Debiopharm (2011). DMWP3G1 RU http://www.debiopharm.com/our-business/pipeline.html DMPXLMB DI DMPXLMB DMPXLMB DN Demobesin DMPXLMB MI TTHYDUM DMPXLMB MN Bombesin receptor (BS) DMPXLMB MT DTT DMPXLMB MA Antagonist DMPXLMB RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 38). DMPXLMB RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=38 DMTULGS DI DMTULGS DMTULGS DN Demogastrin DMTULGS MI TTVFO0U DMTULGS MN Gastrin/cholecystokinin type B receptor (CCKBR) DMTULGS MT DTT DMTULGS MA Modulator DMTULGS RN Demonstration of new sites of expression of the CCK-B/gastrin receptor in pancreatic acinar AR42J cells using immunoelectron microscopy. Regul Pept. 1999 Oct 22;84(1-3):81-9. DMTULGS RU https://pubmed.ncbi.nlm.nih.gov/10535412 DMURVPF DI DMURVPF DMURVPF DN Dendritic cell vaccine DMURVPF MI TT7SBF5 DMURVPF MN Cellular tumor antigen p53 (TP53) DMURVPF MT DTT DMURVPF RN Vaccination with p53-peptide-pulsed dendritic cells, of patients with advanced breast cancer: report from a phase I study. Cancer Immunol Immunother. 2004 Jul;53(7):633-41. DMURVPF RU https://pubmed.ncbi.nlm.nih.gov/14985857 DMTR7EH DI DMTR7EH DMTR7EH DN Desoxypeganine DMTR7EH MI TT1RS9F DMTR7EH MN Acetylcholinesterase (AChE) DMTR7EH MT DTT DMTR7EH MA Modulator DMTR7EH RN Phase I clinical trial with desoxypeganine, a new cholinesterase and selective MAO-A inhibitor: tolerance and pharmacokinetics study of escalating single oral doses. Methods Find Exp Clin Pharmacol. 2008 Mar;30(2):141-7. DMTR7EH RU https://pubmed.ncbi.nlm.nih.gov/18560630 DMTR7EH DI DMTR7EH DMTR7EH DN Desoxypeganine DMTR7EH MI TT3WG5C DMTR7EH MN Monoamine oxidase type A (MAO-A) DMTR7EH MT DTT DMTR7EH MA Modulator DMTR7EH RN Phase I clinical trial with desoxypeganine, a new cholinesterase and selective MAO-A inhibitor: tolerance and pharmacokinetics study of escalating single oral doses. Methods Find Exp Clin Pharmacol. 2008 Mar;30(2):141-7. DMTR7EH RU https://pubmed.ncbi.nlm.nih.gov/18560630 DMAE9I0 DI DMAE9I0 DMAE9I0 DN Dexpirronium DMAE9I0 MI TTH18TF DMAE9I0 MN Muscarinic acetylcholine receptor M5 (CHRM5) DMAE9I0 MT DTT DMAE9I0 MA Antagonist DMAE9I0 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 467). DMAE9I0 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=467 DMI8QNB DI DMI8QNB DMI8QNB DN DFP 13318 DMI8QNB MI TTGTQHC DMI8QNB MN DNA topoisomerase I (TOP1) DMI8QNB MT DTT DMI8QNB MA Inhibitor DMI8QNB RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMI8QNB RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DMY6QFH DI DMY6QFH DMY6QFH DN DFP-11207 DMY6QFH MI TTU6BFZ DMY6QFH MN Candida Thymidylate synthase (Candi TMP1) DMY6QFH MT DTT DMY6QFH MA Inhibitor DMY6QFH RN National Cancer Institute Drug Dictionary (drug id 762603). DMY6QFH RU http://www.cancer.gov/publications/dictionaries/cancer-drug?cdrid=762603 DMGO4XJ DI DMGO4XJ DMGO4XJ DN DFP-14927 DMGO4XJ MI TTATL6Y DMGO4XJ MN DNA-dependent DNA polymerase (DPOL) DMGO4XJ MT DTT DMGO4XJ MA Inhibitor DMGO4XJ RN National Cancer Institute Drug Dictionary (drug name DFP14927). DMGO4XJ RU https://www.cancer.gov/publications/dictionaries/cancer-drug/def/pegylated-deoxycytidine-analogue-dfp-14927 DMGO4XJ DI DMGO4XJ DMGO4XJ DN DFP-14927 DMGO4XJ MI TTUTN1I DMGO4XJ MN Human Deoxyribonucleic acid (hDNA) DMGO4XJ MT DTT DMGO4XJ MA Inhibitor DMGO4XJ RN National Cancer Institute Drug Dictionary (drug name DFP14927). DMGO4XJ RU https://www.cancer.gov/publications/dictionaries/cancer-drug/def/pegylated-deoxycytidine-analogue-dfp-14927 DM6OJI1 DI DM6OJI1 DM6OJI1 DN DIAPLASININ DM6OJI1 MI TTTO43N DM6OJI1 MN Endothelial plasminogen activator inhibitor (SERPINE1) DM6OJI1 MT DTT DM6OJI1 MA Inhibitor DM6OJI1 RN Effect of the small molecule plasminogen activator inhibitor-1 (PAI-1) inhibitor, PAI-749, in clinical models of fibrinolysis. J Thromb Haemost. 2010 Jun;8(6):1333-9. DM6OJI1 RU https://pubmed.ncbi.nlm.nih.gov/20345708 DMPWOH9 DI DMPWOH9 DMPWOH9 DN DKY709 DMPWOH9 MI TTKT5NV DMPWOH9 MN Zinc finger protein Helios (IKZF2) DMPWOH9 MT DTT DMPWOH9 MA Degrader DMPWOH9 RN Targeted protein degraders crowd into the clinic. Nat Rev Drug Discov. 2021 Apr;20(4):247-250. DMPWOH9 RU https://pubmed.ncbi.nlm.nih.gov/33737725 DMM8GZT DI DMM8GZT DMM8GZT DN DL-017 DMM8GZT MI TT34BHT DMM8GZT MN Adrenergic receptor alpha-1D (ADRA1D) DMM8GZT MT DTT DMM8GZT MA Modulator DMM8GZT RN Antihypertensive action and blockade of alpha1-adrenoceptors by DL-017, a quinazoline derivative. J Cardiovasc Pharmacol. 2001 Dec;38(6):893-9. DMM8GZT RU https://pubmed.ncbi.nlm.nih.gov/11707693 DMCT4BA DI DMCT4BA DMCT4BA DN DMUC-5754A DMCT4BA MI TTC1PS3 DMCT4BA MN Ovarian carcinoma antigen CA125 (MUC16) DMCT4BA MT DTT DMCT4BA RN Maturing antibody-drug conjugate pipeline hits 30. Nat Rev Drug Discov. 2013 May;12(5):329-32. DMCT4BA RU https://pubmed.ncbi.nlm.nih.gov/23629491 DMQFX8R DI DMQFX8R DMQFX8R DN DN1406131 DMQFX8R MI TTZJYKH DMQFX8R MN Indoleamine 2,3-dioxygenase 1 (IDO1) DMQFX8R MT DTT DMQFX8R MA Inhibitor DMQFX8R RN ClinicalTrials.gov (NCT03641794) Indoleamine 2,3-Dioxygenase (IDO) Inhibitor in Healthy Volunteers. U.S. National Institutes of Health. DMQFX8R RU https://clinicaltrials.gov/ct2/show/NCT03641794 DMQFX8R DI DMQFX8R DMQFX8R DN DN1406131 DMQFX8R MI TTXNCBV DMQFX8R MN Tryptophan 2,3-dioxygenase (TDO) DMQFX8R MT DTT DMQFX8R MA Inhibitor DMQFX8R RN ClinicalTrials.gov (NCT03641794) Indoleamine 2,3-Dioxygenase (IDO) Inhibitor in Healthy Volunteers. U.S. National Institutes of Health. DMQFX8R RU https://clinicaltrials.gov/ct2/show/NCT03641794 DM0JT9C DI DM0JT9C DM0JT9C DN DN1508052 DM0JT9C MI TT8CWFK DM0JT9C MN Toll-like receptor 8 (TLR8) DM0JT9C MT DTT DM0JT9C MA Agonist DM0JT9C RN Clinical pipeline report, company report or official report of Shanghai De Novo Pharmatech. DM0JT9C RU http://www.denovo-sh.com/En/technology.aspx?BaseInfoCateID=48&CateID=48 DMOSCQ9 DI DMOSCQ9 DMOSCQ9 DN DNL104 DMOSCQ9 MI TTAIQSN DMOSCQ9 MN Receptor-interacting protein 1 (RIPK1) DMOSCQ9 MT DTT DMOSCQ9 MA Inhibitor DMOSCQ9 RN DNL104, a Centrally Penetrant RIPK1 Inhibitor, Inhibits RIP1 Kinase Phosphorylation in a Randomized Phase I Ascending Dose Study in Healthy Volunteers. Clin Pharmacol Ther. 2020 Feb;107(2):406-414. DMOSCQ9 RU https://pubmed.ncbi.nlm.nih.gov/31437302 DMZT89C DI DMZT89C DMZT89C DN DNL151 DMZT89C MI TTK0FEA DMZT89C MN Leucine-rich repeat kinase 2 (LRRK2) DMZT89C MT DTT DMZT89C MA Inhibitor DMZT89C RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMZT89C RU http://phrma-docs.phrma.org/files/dmfile/MID_Neurological-Disorders-Drug-List_2018.pdf DMFEORD DI DMFEORD DMFEORD DN DNL201 DMFEORD MI TTK0FEA DMFEORD MN Leucine-rich repeat kinase 2 (LRRK2) DMFEORD MT DTT DMFEORD MA Inhibitor DMFEORD RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMFEORD RU http://phrma-docs.phrma.org/files/dmfile/MID_Neurological-Disorders-Drug-List_2018.pdf DMNSC0O DI DMNSC0O DMNSC0O DN DNL747 DMNSC0O MI TTAIQSN DMNSC0O MN Receptor-interacting protein 1 (RIPK1) DMNSC0O MT DTT DMNSC0O MA Inhibitor DMNSC0O RN Receptor-interacting protein kinase 1 (RIPK1) as a therapeutic target. Nat Rev Drug Discov. 2020 Aug;19(8):553-571. DMNSC0O RU https://pubmed.ncbi.nlm.nih.gov/32669658 DMZS350 DI DMZS350 DMZS350 DN Donor-derived CD19/22 bispecific CAR-T cells DMZS350 MI TTM6QSK DMZS350 MN B-cell receptor CD22 (CD22) DMZS350 MT DTT DMZS350 MA CAR-T-Cell-Therapy(Dual specific) DMZS350 RN ClinicalTrials.gov (NCT03463928) A Feasibility and Safety Study of Concomitant Therapy With Allo-CAR-T Cells and Allo-HSCT in Patients With Relapse or Refractory Leukemia DMZS350 RU https://clinicaltrials.gov/ct2/show/NCT03463928 DMZS350 DI DMZS350 DMZS350 DN Donor-derived CD19/22 bispecific CAR-T cells DMZS350 MI TTW640A DMZS350 MN B-lymphocyte surface antigen B4 (CD19) DMZS350 MT DTT DMZS350 MA CAR-T-Cell-Therapy(Dual specific) DMZS350 RN ClinicalTrials.gov (NCT03463928) A Feasibility and Safety Study of Concomitant Therapy With Allo-CAR-T Cells and Allo-HSCT in Patients With Relapse or Refractory Leukemia DMZS350 RU https://clinicaltrials.gov/ct2/show/NCT03463928 DMXZ6A0 DI DMXZ6A0 DMXZ6A0 DN DP-4088 DMXZ6A0 MI TT6L509 DMXZ6A0 MN Coagulation factor IIa (F2) DMXZ6A0 MT DTT DMXZ6A0 MA Inhibitor DMXZ6A0 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2362). DMXZ6A0 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2362 DM4ZDOE DI DM4ZDOE DM4ZDOE DN DpC DM4ZDOE MI TTUDR0C DM4ZDOE MN Iron (Fe) DM4ZDOE MT DTT DM4ZDOE MA Chelator DM4ZDOE RN Anticancer Thiosemicarbazones: Chemical Properties, Interaction with Iron Metabolism, and Resistance Development. Antioxid Redox Signal. 2019 Mar 10;30(8):1062-1082. DM4ZDOE RU https://pubmed.ncbi.nlm.nih.gov/29334758 DMJY9TW DI DMJY9TW DMJY9TW DN DRF-1042 DMJY9TW MI TTGTQHC DMJY9TW MN DNA topoisomerase I (TOP1) DMJY9TW MT DTT DMJY9TW MA Inhibitor DMJY9TW RN Safety, tolerability, and pharmacokinetics of a capsule formulation of DRF-1042, a novel camptothecin analog, in refractory cancer patients in a bridging phase I study. J Clin Pharmacol. 2005 Apr;45(4):453-60. DMJY9TW RU https://pubmed.ncbi.nlm.nih.gov/15778426 DM0DJPE DI DM0DJPE DM0DJPE DN Drug 2838232 DM0DJPE MI TTMCA52 DM0DJPE MN Viral Maturation (VM) DM0DJPE MT DTT DM0DJPE MA Modulator DM0DJPE RN Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800037762) DM0DJPE RU http://adisinsight.springer.com/drugs/800037762 DMM57CS DI DMM57CS DMM57CS DN Drug 2849330 DMM57CS MI TTDC8N2 DMM57CS MN Erbb3 tyrosine kinase receptor (Erbb-3) DMM57CS MT DTT DMM57CS RN National Cancer Institute Drug Dictionary (drug id 754219). DMM57CS RU http://www.cancer.gov/publications/dictionaries/cancer-drug?cdrid=754219 DMNFEC6 DI DMNFEC6 DMNFEC6 DN Drug 2878175 DMNFEC6 MI TTMVBWH DMNFEC6 MN Hepatitis C virus RNA-directed RNA polymerase (HCV NS5B) DMNFEC6 MT DTT DMNFEC6 MA Inhibitor DMNFEC6 RN P1224 GSK2878175, A POTENT NON-NUCLEOSIDE INHIBITOR OF HCV NS5B WITH PAN-GENOTYPIC ACTIVITY. Journal of Hepatology Volume 60, Issue 1, Supplement, April 2014, Pages S496. DMNFEC6 RU http://www.sciencedirect.com/science/article/pii/S0168827814613842 DMWXQC9 DI DMWXQC9 DMWXQC9 DN Drug 2881078 DMWXQC9 MI TTS64P2 DMWXQC9 MN Androgen receptor (AR) DMWXQC9 MT DTT DMWXQC9 MA Modulator DMWXQC9 RN Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800039743) DMWXQC9 RU http://adisinsight.springer.com/drugs/800039743 DMXCN37 DI DMXCN37 DMXCN37 DN DS-1040 DMXCN37 MI TTP18AY DMXCN37 MN Carboxypeptidase B2 (CPB2) DMXCN37 MT DTT DMXCN37 MA Modulator DMXCN37 RN Clinical pipeline report, company report or official report of Daiichi Sankyo. DMXCN37 RU http://www.daiichisankyo.com/rd/pipeline/development_pipeline/index.html#details01 DMPR3A6 DI DMPR3A6 DMPR3A6 DN DS-1055 DMPR3A6 MI TT0FAYT DMPR3A6 MN Transforming growth factor beta activator LRRC32 (LRRC32) DMPR3A6 MT DTT DMPR3A6 MA Inhibitor DMPR3A6 RN Clinical pipeline report, company report or official report of Daiichi Sankyo. DMPR3A6 RU https://www.daiichisankyo.com/media/press_release/detail/index_4081.html DM42KZW DI DM42KZW DM42KZW DN DS-1093 DM42KZW MI TTJQFBG DM42KZW MN HIF-prolyl hydroxylase (HPH) DM42KZW MT DTT DM42KZW MA Modulator DM42KZW RN Company report (Daiichisankyo) DM42KZW RU http://www.daiichisankyo.com/rd/pipeline/pdf/Pipeline_EN.pdf DM029TQ DI DM029TQ DM029TQ DN DS-1150b DM029TQ MI TTP6MT5 DM029TQ MN Glucose transporter type 4 (SLC2A4) DM029TQ MT DTT DM029TQ MA Modulator DM029TQ RN Sanford-Burnham goes fourth. SciBX 7(22); doi:10.1038/scibx.2014.633. June 5 2014 DM029TQ RU http://www.nature.com/scibx/journal/v7/n22/full/scibx.2014.633.html DMXST9F DI DMXST9F DMXST9F DN DS-1205 DMXST9F MI TTZPY6J DMXST9F MN Tyrosine-protein kinase UFO (AXL) DMXST9F MT DTT DMXST9F MA Inhibitor DMXST9F RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMXST9F RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DMNDGPT DI DMNDGPT DMNDGPT DN DS-2969 DMNDGPT MI TTPBZUO DMNDGPT MN Clostridium difficile DNA gyrase (CD gyr) DMNDGPT MT DTT DMNDGPT MA Inhibitor DMNDGPT RN In Vitro and In Vivo Activities of DS-2969b, a Novel GyrB Inhibitor, against Clostridium difficile. Antimicrob Agents Chemother. 2018 Mar 27;62(4):e02157-17. DMNDGPT RU https://pubmed.ncbi.nlm.nih.gov/29439962 DMA2B5Y DI DMA2B5Y DMA2B5Y DN DS-3032 DMA2B5Y MI TT08GJW DMA2B5Y MN Ubiquitin-protein ligase E3 Mdm2 (MDM2) DMA2B5Y MT DTT DMA2B5Y MA Inhibitor DMA2B5Y RN Drugging the p53 pathway: understanding the route to clinical efficacy. Nat Rev Drug Discov. 2014 Mar;13(3):217-36. DMA2B5Y RU https://pubmed.ncbi.nlm.nih.gov/24577402 DMG7I5J DI DMG7I5J DMG7I5J DN DS-3078 DMG7I5J MI TTCJG29 DMG7I5J MN Serine/threonine-protein kinase mTOR (mTOR) DMG7I5J MT DTT DMG7I5J MA Modulator DMG7I5J RN A first-in-human Phase I study of DS-3078a, an oral TORC1/2 inhibitor, in patients with advanced solid tumors: Preliminary results, Mol Cancer Ther November,2013, 12, C173. DMG7I5J RU http://mct.aacrjournals.org/content/12/11_Supplement/C173.abstract DMRLPFG DI DMRLPFG DMRLPFG DN DS-3201 DMRLPFG MI TTNJA0C DMRLPFG MN Enhancer of zeste homolog 1 (EZH1) DMRLPFG MT DTT DMRLPFG MA Inhibitor DMRLPFG RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMRLPFG RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DMRLPFG DI DMRLPFG DMRLPFG DN DS-3201 DMRLPFG MI TT9MZCQ DMRLPFG MN Enhancer of zeste homolog 2 (EZH2) DMRLPFG MT DTT DMRLPFG MA Inhibitor DMRLPFG RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMRLPFG RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DM6WN9X DI DM6WN9X DM6WN9X DN DS-3801 DM6WN9X MI TT953CX DM6WN9X MN Motilin receptor (MLNR) DM6WN9X MT DTT DM6WN9X MA Agonist DM6WN9X RN Clinical pipeline report, company report or official report of Daiichi Sankyo. DM6WN9X RU http://www.daiichisankyo.com/rd/pipeline/pdf/Pipeline_EN.pdf DM0RD4F DI DM0RD4F DM0RD4F DN DS-6051 DM0RD4F MI TTSZ6Y3 DM0RD4F MN Proto-oncogene c-Ros (ROS1) DM0RD4F MT DTT DM0RD4F MA Inhibitor DM0RD4F RN National Cancer Institute Drug Dictionary (drug id 766123). DM0RD4F RU http://www.cancer.gov/publications/dictionaries/cancer-drug?cdrid=766123 DM0RD4F DI DM0RD4F DM0RD4F DN DS-6051 DM0RD4F MI TTTDVOJ DM0RD4F MN Tropomyosin-related kinase A (TrkA) DM0RD4F MT DTT DM0RD4F MA Inhibitor DM0RD4F RN National Cancer Institute Drug Dictionary (drug id 766123). DM0RD4F RU http://www.cancer.gov/publications/dictionaries/cancer-drug?cdrid=766123 DMTKZ1Q DI DMTKZ1Q DMTKZ1Q DN DS-6157 DMTKZ1Q MI TTGTQHC DMTKZ1Q MN DNA topoisomerase I (TOP1) DMTKZ1Q MT DTT DMTKZ1Q MA Inhibitor DMTKZ1Q RN Identification and Therapeutic Targeting of GPR20, Selectively Expressed in Gastrointestinal Stromal Tumors, with DS-6157a, a First-in-Class Antibody-Drug Conjugate. Cancer Discov. 2021 Jun;11(6):1508-1523. DMTKZ1Q RU https://pubmed.ncbi.nlm.nih.gov/33579785 DMTKZ1Q DI DMTKZ1Q DMTKZ1Q DN DS-6157 DMTKZ1Q MI TT26C7Z DMTKZ1Q MN G-protein coupled receptor 20 (GPR20) DMTKZ1Q MT DTT DMTKZ1Q MA Inhibitor DMTKZ1Q RN Identification and Therapeutic Targeting of GPR20, Selectively Expressed in Gastrointestinal Stromal Tumors, with DS-6157a, a First-in-Class Antibody-Drug Conjugate. Cancer Discov. 2021 Jun;11(6):1508-1523. DMTKZ1Q RU https://pubmed.ncbi.nlm.nih.gov/33579785 DM7C4U9 DI DM7C4U9 DM7C4U9 DN DS-7309 DM7C4U9 MI TTDLNGZ DM7C4U9 MN Glucokinase (GCK) DM7C4U9 MT DTT DM7C4U9 MA Inhibitor DM7C4U9 RN Glucokinase alternative. SciBX 6(45); doi:10.1038/scibx.2013.1279. Nov. 21 2013 DM7C4U9 RU http://www.nature.com/scibx/journal/v6/n45/full/scibx.2013.1279.html DMCFJM3 DI DMCFJM3 DMCFJM3 DN DS-7423 DMCFJM3 MI TTHBTOP DMCFJM3 MN PI3-kinase gamma (PIK3CG) DMCFJM3 MT DTT DMCFJM3 MA Modulator DMCFJM3 RN Antitumor activity and induction of TP53-dependent apoptosis toward ovarian clear cell adenocarcinoma by the dual PI3K/mTOR inhibitor DS-7423. PLoS One. 2014 Feb 4;9(2):e87220. DMCFJM3 RU https://pubmed.ncbi.nlm.nih.gov/24504419 DMCFJM3 DI DMCFJM3 DMCFJM3 DN DS-7423 DMCFJM3 MI TTCJG29 DMCFJM3 MN Serine/threonine-protein kinase mTOR (mTOR) DMCFJM3 MT DTT DMCFJM3 MA Modulator DMCFJM3 RN Antitumor activity and induction of TP53-dependent apoptosis toward ovarian clear cell adenocarcinoma by the dual PI3K/mTOR inhibitor DS-7423. PLoS One. 2014 Feb 4;9(2):e87220. DMCFJM3 RU https://pubmed.ncbi.nlm.nih.gov/24504419 DMJPUDW DI DMJPUDW DMJPUDW DN DS-8273 DMJPUDW MI TTW20TU DMJPUDW MN TRAIL receptor 2 (TRAIL-R2) DMJPUDW MT DTT DMJPUDW MA Agonist DMJPUDW RN First-in-human study of the antibody DR5 agonist DS-8273a in patients with advanced solid tumors. Invest New Drugs. 2017 Jun;35(3):298-306. DMJPUDW RU https://pubmed.ncbi.nlm.nih.gov/28050790 DM31VNC DI DM31VNC DM31VNC DN DS-8895 DM31VNC MI TTRJB2G DM31VNC MN Ephrin type-A receptor 2 (EPHA2) DM31VNC MT DTT DM31VNC RN Clinical pipeline report, company report or official report of Daiichi Sankyo. DM31VNC RU http://www.daiichisankyo.com/rd/pipeline/pdf/Pipeline_EN.pdf DM4ZCY0 DI DM4ZCY0 DM4ZCY0 DN DSP-0337 DM4ZCY0 MI TTH8FZW DM4ZCY0 MN Signal transducer and activator of transcription 3 (STAT3) DM4ZCY0 MT DTT DM4ZCY0 MA Inhibitor DM4ZCY0 RN Napabucasin, a novel STAT3 inhibitor suppresses proliferation, invasion and stemness of glioblastoma cells. J Exp Clin Cancer Res. 2019 Jul 5;38(1):289. DM4ZCY0 RU https://pubmed.ncbi.nlm.nih.gov/31277685 DMY95MZ DI DMY95MZ DMY95MZ DN DSP-0565 DMY95MZ MI TT5HONZ DMY95MZ MN Calcium channel unspecific (CaC) DMY95MZ MT DTT DMY95MZ MA Modulator DMY95MZ RN Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800035668) DMY95MZ RU http://adisinsight.springer.com/drugs/800035668 DMJDP0E DI DMJDP0E DMJDP0E DN DSP-1053 DMJDP0E MI TTSQIFT DMJDP0E MN 5-HT 1A receptor (HTR1A) DMJDP0E MT DTT DMJDP0E MA Antagonist DMJDP0E RN DSP-1053, a novel serotonin reuptake inhibitor with 5-HT1A partial agonistic activity, displays fast antidepressant effect with minimal undesirable effects in juvenile rats. Pharmacol Res Perspect. 2015 Jun;3(3):e00142. DMJDP0E RU https://pubmed.ncbi.nlm.nih.gov/26171224 DM4WSHG DI DM4WSHG DM4WSHG DN DSP-1200 DM4WSHG MI TTJQOD7 DM4WSHG MN 5-HT 2A receptor (HTR2A) DM4WSHG MT DTT DM4WSHG MA Antagonist DM4WSHG RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DM4WSHG RU http://phrma-docs.phrma.org/files/dmfile/MID_Mental-Illness-2017-Drug-List_Final.pdf DM4WSHG DI DM4WSHG DM4WSHG DN DSP-1200 DM4WSHG MI TTWG9A4 DM4WSHG MN Adrenergic receptor alpha-2A (ADRA2A) DM4WSHG MT DTT DM4WSHG MA Antagonist DM4WSHG RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DM4WSHG RU http://phrma-docs.phrma.org/files/dmfile/MID_Mental-Illness-2017-Drug-List_Final.pdf DM4WSHG DI DM4WSHG DM4WSHG DN DSP-1200 DM4WSHG MI TTEX248 DM4WSHG MN Dopamine D2 receptor (D2R) DM4WSHG MT DTT DM4WSHG MA Antagonist DM4WSHG RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DM4WSHG RU http://phrma-docs.phrma.org/files/dmfile/MID_Mental-Illness-2017-Drug-List_Final.pdf DM0WTMD DI DM0WTMD DM0WTMD DN DSP-2230 DM0WTMD MI TT4G2JS DM0WTMD MN Voltage-gated sodium channel alpha Nav1.7 (SCN9A) DM0WTMD MT DTT DM0WTMD MA Inhibitor DM0WTMD RN Antibodies and venom peptides: new modalities for ion channels. Nat Rev Drug Discov. 2019 May;18(5):339-357. DM0WTMD RU https://pubmed.ncbi.nlm.nih.gov/30728472 DM0WTMD DI DM0WTMD DM0WTMD DN DSP-2230 DM0WTMD MI TT90XZ8 DM0WTMD MN Voltage-gated sodium channel alpha Nav1.8 (SCN10A) DM0WTMD MT DTT DM0WTMD MA Inhibitor DM0WTMD RN Antibodies and venom peptides: new modalities for ion channels. Nat Rev Drug Discov. 2019 May;18(5):339-357. DM0WTMD RU https://pubmed.ncbi.nlm.nih.gov/30728472 DMYHU24 DI DMYHU24 DMYHU24 DN DSP-3905 DMYHU24 MI TT4G2JS DMYHU24 MN Voltage-gated sodium channel alpha Nav1.7 (SCN9A) DMYHU24 MT DTT DMYHU24 MA Inhibitor DMYHU24 RN Antibodies and venom peptides: new modalities for ion channels. Nat Rev Drug Discov. 2019 May;18(5):339-357. DMYHU24 RU https://pubmed.ncbi.nlm.nih.gov/30728472 DMM86OH DI DMM86OH DMM86OH DN DSP-6745 DMM86OH MI TT85JO3 DMM86OH MN 5-HT receptor (5HTR) DMM86OH MT DTT DMM86OH MA Antagonist DMM86OH RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMM86OH RU http://phrma-docs.phrma.org/files/dmfile/MID_Neurological-Disorders-Drug-List_2018.pdf DM2PYE0 DI DM2PYE0 DM2PYE0 DN DSP-8658 DM2PYE0 MI TTZMAO3 DM2PYE0 MN Peroxisome proliferator-activated receptor gamma (PPAR-gamma) DM2PYE0 MT DTT DM2PYE0 MA Modulator DM2PYE0 RN Effects of DSP-8658, a Novel Selective Peroxisome Proliferator-activated Receptors a/gamma Modulator, on Adipogenesis and Glucose Metabolism in Diabetic Obese Mice. Exp Clin Endocrinol Diabetes. 2015Sep;123(8):492-9. DM2PYE0 RU https://pubmed.ncbi.nlm.nih.gov/26011171 DM69ZBU DI DM69ZBU DM69ZBU DN DST-2970 DM69ZBU MI TTRA5BZ DM69ZBU MN Steroid 17-alpha-monooxygenase (S17AH) DM69ZBU MT DTT DM69ZBU MA Inhibitor DM69ZBU RN Clinical pipeline report, company report or official report of DisperSol Technologies. DM69ZBU RU https://www.dispersoltech.com/pipeline/ DMYFOJQ DI DMYFOJQ DMYFOJQ DN DT-200 DMYFOJQ MI TTS64P2 DMYFOJQ MN Androgen receptor (AR) DMYFOJQ MT DTT DMYFOJQ MA Modulator DMYFOJQ RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMYFOJQ RU http://phrma-docs.phrma.org/files/dmfile/MID_Neurological-Disorders-Drug-List_2018.pdf DM5AGKV DI DM5AGKV DM5AGKV DN DTRMWXHS-12 DM5AGKV MI TTGM6VW DM5AGKV MN Tyrosine-protein kinase BTK (ATK) DM5AGKV MT DTT DM5AGKV MA Inhibitor DM5AGKV RN ClinicalTrials.gov (NCT02900716) Safety Study of BTK Inhibitor, DTRMWXHS-12, Used Singly or in Combination, in CLL and B-cell Lymphomas. U.S. National Institutes of Health. DM5AGKV RU https://clinicaltrials.gov/ct2/show/NCT02900716 DM1FX09 DI DM1FX09 DM1FX09 DN DT-TX-30 DM1FX09 MI TT2O84V DM1FX09 MN Thromboxane A2 receptor (TBXA2R) DM1FX09 MT DTT DM1FX09 MA Antagonist DM1FX09 RN DTTX30, a combined thromboxane receptor antagonist and thromboxane synthetase inhibitor, prevents coronary thrombosis in anesthetized dogs. Basic Res Cardiol. 1997 Jun;92(3):181-90. DM1FX09 RU https://pubmed.ncbi.nlm.nih.gov/9226103 DM8WBNF DI DM8WBNF DM8WBNF DN DTX401 DM8WBNF MI TTBQMJ8 DM8WBNF MN Glucose-6-phosphatase (G6PC) DM8WBNF MT DTT DM8WBNF MA Replacement DM8WBNF RN Clinical pipeline report, company report or official report of Ultragenyx Pharmaceutical. DM8WBNF RU https://www.ultragenyx.com/pipeline/dtx-401-for-gsd1a/ DM3P0H1 DI DM3P0H1 DM3P0H1 DN Duvortuxizumab DM3P0H1 MI TTW640A DM3P0H1 MN B-lymphocyte surface antigen B4 (CD19) DM3P0H1 MT DTT DM3P0H1 RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DM3P0H1 RU http://phrma-docs.phrma.org/files/dmfile/MID_Immuno-Oncology-2017_Drug-List1.pdf DMDSVRP DI DMDSVRP DMDSVRP DN DV-1179 DMDSVRP MI TTRJ1K4 DMDSVRP MN Toll-like receptor 7 (TLR7) DMDSVRP MT DTT DMDSVRP MA Modulator DMDSVRP RN Company report (Dynavax) DMDSVRP RU http://www.dynavax.com/our-pipeline/immune-mediated-diseases/dv1179/ DMDSVRP DI DMDSVRP DMDSVRP DN DV-1179 DMDSVRP MI TTSHG0T DMDSVRP MN Toll-like receptor 9 (TLR9) DMDSVRP MT DTT DMDSVRP MA Modulator DMDSVRP RN Company report (Dynavax) DMDSVRP RU http://www.dynavax.com/our-pipeline/immune-mediated-diseases/dv1179/ DMJ0Y86 DI DMJ0Y86 DMJ0Y86 DN DV281 DMJ0Y86 MI TTSHG0T DMJ0Y86 MN Toll-like receptor 9 (TLR9) DMJ0Y86 MT DTT DMJ0Y86 MA Agonist DMJ0Y86 RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMJ0Y86 RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DMQKDJZ DI DMQKDJZ DMQKDJZ DN DWJ-208 DMQKDJZ MI TT4G2JS DMQKDJZ MN Voltage-gated sodium channel alpha Nav1.7 (SCN9A) DMQKDJZ MT DTT DMQKDJZ MA Antagonist DMQKDJZ RN Antibodies and venom peptides: new modalities for ion channels. Nat Rev Drug Discov. 2019 May;18(5):339-357. DMQKDJZ RU https://pubmed.ncbi.nlm.nih.gov/30728472 DM4XZY9 DI DM4XZY9 DM4XZY9 DN DWP-09031 DM4XZY9 MI TTE4KHA DM4XZY9 MN Amyloid beta A4 protein (APP) DM4XZY9 MT DTT DM4XZY9 MA Inhibitor DM4XZY9 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2402). DM4XZY9 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2402 DMS1NC8 DI DMS1NC8 DMS1NC8 DN DZ-2640 DMS1NC8 MI TTJP4SM DMS1NC8 MN Bacterial Penicillin binding protein (Bact PBP) DMS1NC8 MT DTT DMS1NC8 MA Modulator DMS1NC8 RN In vitro activity of DU-6681a, an active form of the new oral carbapenem compound DZ-2640, in comparison with that of R-95867, faropenem and oral cephalosporins. J Antimicrob Chemother. 2000 Jul;46(1):101-8. DMS1NC8 RU https://pubmed.ncbi.nlm.nih.gov/10882697 DMEQY4Z DI DMEQY4Z DMEQY4Z DN DZD1516 DMEQY4Z MI TT6EO5L DMEQY4Z MN Erbb2 tyrosine kinase receptor (HER2) DMEQY4Z MT DTT DMEQY4Z MA Inhibitor DMEQY4Z RN ClinicalTrials.gov (NCT04509596) DZD1516 in Combination With Trastuzumab and Capecitabine, or in Combination With T-DM1, in Patients With Metastatic HER2 Positive Breast Cancer. U.S. National Institutes of Health. DMEQY4Z RU https://clinicaltrials.gov/ct2/show/NCT04509596 DM3LOF1 DI DM3LOF1 DM3LOF1 DN E 7974 DM3LOF1 MI TTML2WA DM3LOF1 MN Tubulin (TUB) DM3LOF1 MT DTT DM3LOF1 MA Inhibitor DM3LOF1 RN Emerging drugs for ovarian cancer. Expert Opin Emerg Drugs. 2008 Sep;13(3):523-36. DM3LOF1 RU https://pubmed.ncbi.nlm.nih.gov/18764727 DMNEVKA DI DMNEVKA DMNEVKA DN E2012 DMNEVKA MI TT9W8GU DMNEVKA MN Gamma-secretase (GS) DMNEVKA MT DTT DMNEVKA MA Modulator DMNEVKA RN Chemical Biology, Molecular Mechanism and Clinical Perspective of -Secretase Modulators in Alzheimer's Disease.Curr Neuropharmacol.2011 Dec;9(4):598-622. DMNEVKA RU https://www.ncbi.nlm.nih.gov/pubmed/22798753 DMQDKYV DI DMQDKYV DMQDKYV DN E-2212 DMQDKYV MI TT9W8GU DMQDKYV MN Gamma-secretase (GS) DMQDKYV MT DTT DMQDKYV MA Modulator DMQDKYV RN Development and mechanism of gamma-secretase modulators for Alzheimer's disease. Biochemistry. 2013 May 14;52(19):3197-216. DMQDKYV RU https://pubmed.ncbi.nlm.nih.gov/23614767 DM4BD5U DI DM4BD5U DM4BD5U DN E2730 DM4BD5U MI TTPW8EF DM4BD5U MN Synaptic transmission (ST) DM4BD5U MT DTT DM4BD5U MA Modulator DM4BD5U RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DM4BD5U RU http://phrma-docs.phrma.org/files/dmfile/MID_Neurological-Disorders-Drug-List_2018.pdf DMFVT43 DI DMFVT43 DMFVT43 DN E7046 DMFVT43 MI TT79WV3 DMFVT43 MN Prostaglandin E2 receptor EP4 (PTGER4) DMFVT43 MT DTT DMFVT43 MA Antagonist DMFVT43 RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMFVT43 RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DMDOCNW DI DMDOCNW DMDOCNW DN E-7050 DMDOCNW MI TTNDSF4 DMDOCNW MN Proto-oncogene c-Met (MET) DMDOCNW MT DTT DMDOCNW MA Modulator DMDOCNW RN E7050: a dual c-Met and VEGFR-2 tyrosine kinase inhibitor promotes tumor regression and prolongs survival in mouse xenograft models. Cancer Sci. 2010 Jan;101(1):210-5. DMDOCNW RU https://pubmed.ncbi.nlm.nih.gov/19832844 DMDOCNW DI DMDOCNW DMDOCNW DN E-7050 DMDOCNW MI TTUTJGQ DMDOCNW MN Vascular endothelial growth factor receptor 2 (KDR) DMDOCNW MT DTT DMDOCNW MA Modulator DMDOCNW RN E7050: a dual c-Met and VEGFR-2 tyrosine kinase inhibitor promotes tumor regression and prolongs survival in mouse xenograft models. Cancer Sci. 2010 Jan;101(1):210-5. DMDOCNW RU https://pubmed.ncbi.nlm.nih.gov/19832844 DM8TU5R DI DM8TU5R DM8TU5R DN E7766 DM8TU5R MI TTT402Y DM8TU5R MN Stimulator of interferon genes protein (TMEM173) DM8TU5R MT DTT DM8TU5R MA Agonist DM8TU5R RN E7766, a Macrocycle-Bridged Stimulator of Interferon Genes (STING) Agonist with Potent Pan-Genotypic Activity. ChemMedChem. 2021 Jun 7;16(11):1740-1743. DM8TU5R RU https://pubmed.ncbi.nlm.nih.gov/33522135 DM8RD4T DI DM8RD4T DM8RD4T DN EC0489 DM8RD4T MI TTVC37M DM8RD4T MN Folate receptor alpha (FOLR1) DM8RD4T MT DTT DM8RD4T MA Modulator DM8RD4T RN National Cancer Institute Drug Dictionary (drug id 638649). DM8RD4T RU http://www.cancer.gov/publications/dictionaries/cancer-drug?cdrid=638649 DMXW07J DI DMXW07J DMXW07J DN EDP-239 DMXW07J MI TTCJ2X8 DMXW07J MN Hepatitis C virus Non-structural 5A (HCV NS5A) DMXW07J MT DTT DMXW07J MA Modulator DMXW07J RN Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41. DMXW07J RU https://www.ncbi.nlm.nih.gov/pubmed/15950434 DMWTVM1 DI DMWTVM1 DMWTVM1 DN EDP-322 DMWTVM1 MI TT3OT40 DMWTVM1 MN Multidrug resistance protein 1 (ABCB1) DMWTVM1 MT DTT DMWTVM1 MA Inhibitor DMWTVM1 RN In vitro activities of the novel bicyclolides modithromycin (EDP-420, EP-013420, S-013420) and EDP-322 against MDR clinical Neisseria gonorrhoeae isolates and international reference strains. J Antimicrob Chemother. 2015 Jan;70(1):173-7. DMWTVM1 RU https://pubmed.ncbi.nlm.nih.gov/25182063 DM8KRA3 DI DM8KRA3 DM8KRA3 DN EDP-514 DM8KRA3 MI TTM42UJ DM8KRA3 MN Hepatitis B virus Capsid protein (HBV C) DM8KRA3 MT DTT DM8KRA3 MA Inhibitor DM8KRA3 RN Clinical pipeline report, company report or official report of Enanta Pharmaceuticals. DM8KRA3 RU https://www.enanta.com/investors/news-releases/press-release/2020/Enanta-Pharmaceuticals-Announces-Clinical-Trial-Progress-for-EDP-514-its-Lead-Core-Inhibitor-for-Hepatitis-B-Virus/default.aspx DM3AD65 DI DM3AD65 DM3AD65 DN EGFR806-specific CAR T cell DM3AD65 MI TTGKNB4 DM3AD65 MN Epidermal growth factor receptor (EGFR) DM3AD65 MT DTT DM3AD65 MA CAR-T-Cell-Therapy DM3AD65 RN ClinicalTrials.gov (NCT03638167) EGFR806-specific CAR T Cell Locoregional Immunotherapy for EGFR-positive Recurrent or Refractory Pediatric CNS Tumors DM3AD65 RU https://clinicaltrials.gov/ct2/show/NCT03638167 DMZN35T DI DMZN35T DMZN35T DN EGFRt/19-28z/4-1BBL CAR T cells DMZN35T MI TTW640A DMZN35T MN B-lymphocyte surface antigen B4 (CD19) DMZN35T MT DTT DMZN35T MA CAR-T-Cell-Therapy DMZN35T RN ClinicalTrials.gov (NCT03085173) A Trial of "Armored" CAR T Cells Targeting CD19 For Patients With Relapsed CD19+ Hematologic Malignancies DMZN35T RU https://clinicaltrials.gov/ct2/show/NCT03085173 DM6XWV4 DI DM6XWV4 DM6XWV4 DN EGFRvIII CAR T cells DM6XWV4 MI TTZ6B2I DM6XWV4 MN Epidermal growth factor receptor variant III (EGFR vIII) DM6XWV4 MT DTT DM6XWV4 MA CAR-T-Cell-Therapy DM6XWV4 RN ClinicalTrials.gov (NCT02664363) EGFRvIII CAR T Cells for Newly-Diagnosed WHO Grade IV Malignant Glioma DM6XWV4 RU https://clinicaltrials.gov/ct2/show/NCT02664363 DMA46RN DI DMA46RN DMA46RN DN EGFRvIII-CARs DMA46RN MI TTZ6B2I DMA46RN MN Epidermal growth factor receptor variant III (EGFR vIII) DMA46RN MT DTT DMA46RN MA CAR-T-Cell-Therapy DMA46RN RN ClinicalTrials.gov (NCT03283631) Intracerebral EGFR-vIII CAR-T Cells for Recurrent GBM DMA46RN RU https://clinicaltrials.gov/ct2/show/NCT03283631 DMDPGCS DI DMDPGCS DMDPGCS DN EGT-0001474 DMDPGCS MI TTLWPVF DMDPGCS MN Sodium/glucose cotransporter 2 (SGLT2) DMDPGCS MT DTT DMDPGCS MA Modulator DMDPGCS RN PhRMA report DMDPGCS RU http://www.phrma.org/sites/default/files/pdf/diabetes2012.pdf DMXAUB7 DI DMXAUB7 DMXAUB7 DN EI1071 DMXAUB7 MI TT7MRDV DMXAUB7 MN Macrophage colony-stimulating factor 1 receptor (CSF1R) DMXAUB7 MT DTT DMXAUB7 MA Inhibitor DMXAUB7 RN Clinical pipeline report, company report or official report of Elixiron Immunotherapeutics. DMXAUB7 RU https://www.elixiron.com/ DMA4BRV DI DMA4BRV DMA4BRV DN Elinogrel DMA4BRV MI TTZ1DT0 DMA4BRV MN P2Y purinoceptor 12 (P2RY12) DMA4BRV MT DTT DMA4BRV MA Antagonist DMA4BRV RN Elinogrel, a reversible P2Y12 receptor antagonist for the treatment of acute coronary syndrome and prevention of secondary thrombotic events. Curr Opin Investig Drugs. 2010 Mar;11(3):340-8. DMA4BRV RU https://pubmed.ncbi.nlm.nih.gov/20178048 DMM9S51 DI DMM9S51 DMM9S51 DN ELND-002 DMM9S51 MI TT4BT06 DMM9S51 MN Integrin alpha-4 (ITGA4) DMM9S51 MT DTT DMM9S51 MA Antagonist DMM9S51 RN Paxillin binding to the alpha 4 integrin subunit stimulates LFA-1 (integrin alpha L beta 2)-dependent T cell migration by augmenting the activation of focal adhesion kinase/proline-rich tyrosine kinase-2. J Immunol. 2003 Jun 15;170(12):5912-8. DMM9S51 RU https://pubmed.ncbi.nlm.nih.gov/12794117 DMLQYVD DI DMLQYVD DMLQYVD DN ELND-004 DMLQYVD MI TT4BT06 DMLQYVD MN Integrin alpha-4 (ITGA4) DMLQYVD MT DTT DMLQYVD MA Inhibitor DMLQYVD RN Paxillin binding to the alpha 4 integrin subunit stimulates LFA-1 (integrin alpha L beta 2)-dependent T cell migration by augmenting the activation of focal adhesion kinase/proline-rich tyrosine kinase-2. J Immunol. 2003 Jun 15;170(12):5912-8. DMLQYVD RU https://pubmed.ncbi.nlm.nih.gov/12794117 DMQPI4V DI DMQPI4V DMQPI4V DN ELOMOTECAN HYDROCHLORIDE DMQPI4V MI TTGTQHC DMQPI4V MN DNA topoisomerase I (TOP1) DMQPI4V MT DTT DMQPI4V MA Modulator DMQPI4V RN The dual topoisomerase inhibitor, BN 80927, is highly potent against cell proliferation and tumor growth. Ann N Y Acad Sci. 2000;922:303-5. DMQPI4V RU https://www.ncbi.nlm.nih.gov/pubmed/11193907 DMIV04R DI DMIV04R DMIV04R DN Elpetrigine DMIV04R MI TT5HONZ DMIV04R MN Calcium channel unspecific (CaC) DMIV04R MT DTT DMIV04R MA Blocker DMIV04R RN Clinical pipeline report, company report or official report of Jazz Pharmaceuticals. DMIV04R RU http://www.jazzpharma.com/products/ DM4W7Z0 DI DM4W7Z0 DM4W7Z0 DN Emactuzumab DM4W7Z0 MI TT0IQER DM4W7Z0 MN Macrophage colony-stimulating factor 1 (CSF1) DM4W7Z0 MT DTT DM4W7Z0 MA Antagonist DM4W7Z0 RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DM4W7Z0 RU http://phrma-docs.phrma.org/files/dmfile/MID_Immuno-Oncology-2017_Drug-List1.pdf DM6AMKZ DI DM6AMKZ DM6AMKZ DN Embeconazole DM6AMKZ MI TTTSOUD DM6AMKZ MN Candida Cytochrome P450 51 (Candi ERG11) DM6AMKZ MT DTT DM6AMKZ MA Inhibitor DM6AMKZ RN CS-758. Antifungal lanosterol 14alpha-demethylase inhibitor, 003, vol28, no3, 217-223. DM6AMKZ RU http://cat.inist.fr/?aModele=afficheN&cpsidt=14796964 DM38JZU DI DM38JZU DM38JZU DN EMD-1204831 DM38JZU MI TTNDSF4 DM38JZU MN Proto-oncogene c-Met (MET) DM38JZU MT DTT DM38JZU MA Inhibitor DM38JZU RN 2012 ASCO Annual Meeting. DM38JZU RU http://meetinglibrary.asco.org/subcategories/2012%20ASCO%20Annual%20Meeting DMQ6YAZ DI DMQ6YAZ DMQ6YAZ DN EMD-534085 DMQ6YAZ MI TTBGTCW DMQ6YAZ MN Kinesin spindle messenger RNA (KIF11 mRNA) DMQ6YAZ MT DTT DMQ6YAZ MA Inhibitor DMQ6YAZ RN The discovery and optimization of hexahydro-2H-pyrano[3,2-c]quinolines (HHPQs) as potent and selective inhibitors of the mitotic kinesin-5. Bioorg Med Chem Lett. 2010 Mar 1;20(5):1491-5. DMQ6YAZ RU https://pubmed.ncbi.nlm.nih.gov/20149654 DMBIPQL DI DMBIPQL DMBIPQL DN Enavatuzumab DMBIPQL MI TTKPS7V DMBIPQL MN TNF superfamily receptor 12A (TNFRSF12A) DMBIPQL MT DTT DMBIPQL RN Expression of TweakR in breast cancer and preclinical activity of enavatuzumab, a humanized anti-TweakR mAb. J Cancer Res Clin Oncol. 2013 Feb;139(2):315-25. DMBIPQL RU https://pubmed.ncbi.nlm.nih.gov/23073510 DMKPBVX DI DMKPBVX DMKPBVX DN Englitazone sodium DMKPBVX MI TTZMAO3 DMKPBVX MN Peroxisome proliferator-activated receptor gamma (PPAR-gamma) DMKPBVX MT DTT DMKPBVX MA Agonist DMKPBVX RN PPARgamma agonists in the treatment of type II diabetes: is increased fatness commensurate with long-term efficacy. Int J Obes Relat Metab Disord. 2003 Feb;27(2):147-61. DMKPBVX RU https://pubmed.ncbi.nlm.nih.gov/12586994 DMGLHYU DI DMGLHYU DMGLHYU DN Enkastim-ev DMGLHYU MI TTHYBIX DMGLHYU MN Heat shock protein 70 (HSP70) DMGLHYU MT DTT DMGLHYU MA Modulator DMGLHYU RN Company report (Multimmune) DMGLHYU RU http://www.multimmune.com/mi-THERAPEUTICS-PIPELINE/ DM9BJ3G DI DM9BJ3G DM9BJ3G DN ENMD-1198 DM9BJ3G MI TTQHWNA DM9BJ3G MN Hypoxia-inducible factor 1 alpha (HIF-1A) DM9BJ3G MT DTT DM9BJ3G MA Inhibitor DM9BJ3G RN ENMD-1198, a new analogue of 2-methoxyestradiol, displays both antiangiogenic and vascular-disrupting properties. Mol Cancer Ther. 2010 May;9(5):1408-18. DM9BJ3G RU https://pubmed.ncbi.nlm.nih.gov/20442304 DMMJXAR DI DMMJXAR DMMJXAR DN Entolimod DMMJXAR MI TTCXP8J DMMJXAR MN Toll-like receptor 5 (TLR5) DMMJXAR MT DTT DMMJXAR MA Agonist DMMJXAR RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMMJXAR RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DMQ6GUY DI DMQ6GUY DMQ6GUY DN EOS100850 DMQ6GUY MI TTM2AOE DMQ6GUY MN Adenosine A2a receptor (ADORA2A) DMQ6GUY MT DTT DMQ6GUY MA Antagonist DMQ6GUY RN National Cancer Institute Drug Dictionary (drug name EOS100850). DMQ6GUY RU https://www.cancer.gov/publications/dictionaries/cancer-drug/def/a2a-receptor-antagonist-eos100850 DMKR3GD DI DMKR3GD DMKR3GD DN EP-42675 DMKR3GD MI TT6L509 DMKR3GD MN Coagulation factor IIa (F2) DMKR3GD MT DTT DMKR3GD MA Modulator DMKR3GD RN EP42675, a synthetic parenteral dual-action anticoagulant: pharmacokinetics, pharmacodynamics, and absence of interactions with antiplatelet drugs. J Thromb Haemost. 2014 Jan;12(1):24-33. DMKR3GD RU https://pubmed.ncbi.nlm.nih.gov/24237610 DMKR3GD DI DMKR3GD DMKR3GD DN EP-42675 DMKR3GD MI TTCIHJA DMKR3GD MN Coagulation factor Xa (F10) DMKR3GD MT DTT DMKR3GD MA Modulator DMKR3GD RN EP42675, a synthetic parenteral dual-action anticoagulant: pharmacokinetics, pharmacodynamics, and absence of interactions with antiplatelet drugs. J Thromb Haemost. 2014 Jan;12(1):24-33. DMKR3GD RU https://pubmed.ncbi.nlm.nih.gov/24237610 DM49RI7 DI DM49RI7 DM49RI7 DN EP-51216 DM49RI7 MI TTKMAZ6 DM49RI7 MN Growth hormone receptor (GHR) DM49RI7 MT DTT DM49RI7 MA Agonist DM49RI7 RN Emerging drugs for eating disorder treatment. Expert Opin Emerg Drugs. 2006 May;11(2):315-36. DM49RI7 RU https://pubmed.ncbi.nlm.nih.gov/16634704 DMW739O DI DMW739O DMW739O DN EP-51389 DMW739O MI TTKMAZ6 DMW739O MN Growth hormone receptor (GHR) DMW739O MT DTT DMW739O MA Agonist DMW739O RN Emerging drugs for eating disorder treatment. Expert Opin Emerg Drugs. 2006 May;11(2):315-36. DMW739O RU https://pubmed.ncbi.nlm.nih.gov/16634704 DMV0MHI DI DMV0MHI DMV0MHI DN EP-7041 DMV0MHI MI TTJCPUT DMV0MHI MN Coagulation factor XI (F11) DMV0MHI MT DTT DMV0MHI MA Inhibitor DMV0MHI RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMV0MHI RU http://phrma-docs.phrma.org/files/dmfile/2018_Heart-Disease-and-Stroke_MID-Drug-List.pdf DMUFN29 DI DMUFN29 DMUFN29 DN EPI-7386 DMUFN29 MI TTS64P2 DMUFN29 MN Androgen receptor (AR) DMUFN29 MT DTT DMUFN29 MA Inhibitor DMUFN29 RN Clinical pipeline report, company report or official report of ESSA Pharma. DMUFN29 RU https://www.essapharma.com/pipeline/ DMAQYRL DI DMAQYRL DMAQYRL DN Eptacog alfa DMAQYRL MI TTF0EGX DMAQYRL MN Coagulation factor VII (F7) DMAQYRL MT DTT DMAQYRL MA Modulator DMAQYRL RN Recombinant factor VIIa (eptacog alfa): a review of its use in congenital hemophilia with inhibitors, acquired hemophilia, and other congenital bleeding disorders. BioDrugs. 2008;22(2):121-36. DMAQYRL RU https://pubmed.ncbi.nlm.nih.gov/18345709 DMXI9P4 DI DMXI9P4 DMXI9P4 DN EPX-100 DMXI9P4 MI TT85JO3 DMXI9P4 MN 5-HT receptor (5HTR) DMXI9P4 MT DTT DMXI9P4 MA Modulator DMXI9P4 RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMXI9P4 RU http://phrma-docs.phrma.org/files/dmfile/MID_Neurological-Disorders-Drug-List_2018.pdf DMKMR2X DI DMKMR2X DMKMR2X DN ERB-257 DMKMR2X MI TTOM3J0 DMKMR2X MN Estrogen receptor beta (ESR2) DMKMR2X MT DTT DMKMR2X MA Agonist DMKMR2X RN Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800030075) DMKMR2X RU http://adisinsight.springer.com/drugs/800030075 DM9YNTO DI DM9YNTO DM9YNTO DN ERY974 DM9YNTO MI TTJTSX4 DM9YNTO MN Glypican-3 (GPC3) DM9YNTO MT DTT DM9YNTO MA Inhibitor DM9YNTO RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DM9YNTO RU http://phrma-docs.phrma.org/files/dmfile/MID_Immuno-Oncology-2017_Drug-List1.pdf DMY0HU6 DI DMY0HU6 DMY0HU6 DN ETC-1922159 DMY0HU6 MI TTNFBTO DMY0HU6 MN Protein-serine O-palmitoleoyltransferase porcupine (PORCN) DMY0HU6 MT DTT DMY0HU6 MA Inhibitor DMY0HU6 RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMY0HU6 RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DMS436I DI DMS436I DMS436I DN ETX201 DMS436I MI TTZXH48 DMS436I MN TNF receptor (TNFR) DMS436I MT DTT DMS436I MA Antagonist DMS436I RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMS436I RU http://phrma-docs.phrma.org/files/dmfile/medicines-in-development-drug-list-autoimmune-diseases.pdf DMY9ZAS DI DMY9ZAS DMY9ZAS DN EUK-189 DMY9ZAS MI TTPS279 DMY9ZAS MN Catalase (CAT) DMY9ZAS MT DTT DMY9ZAS MA Modulator DMY9ZAS RN Evaluation of EUK-189, a synthetic superoxide dismutase/catalase mimetic as a radiation countermeasure. Immunopharmacol Immunotoxicol. 2008;30(2):271-90. DMY9ZAS RU https://pubmed.ncbi.nlm.nih.gov/18569084 DMY9ZAS DI DMY9ZAS DMY9ZAS DN EUK-189 DMY9ZAS MI TT6RVLG DMY9ZAS MN Superoxide dismutase Cu-Zn (SOD Cu-Zn) DMY9ZAS MT DTT DMY9ZAS MA Modulator DMY9ZAS RN Evaluation of EUK-189, a synthetic superoxide dismutase/catalase mimetic as a radiation countermeasure. Immunopharmacol Immunotoxicol. 2008;30(2):271-90. DMY9ZAS RU https://pubmed.ncbi.nlm.nih.gov/18569084 DMOG8IE DI DMOG8IE DMOG8IE DN EVT 401 DMOG8IE MI TT473XN DMOG8IE MN P2X purinoceptor 7 (P2RX7) DMOG8IE MT DTT DMOG8IE MA Antagonist DMOG8IE RN Molecular and functional properties of P2X receptors ecent progress and persisting challenges. Purinergic Signal. 2012 September; 8(3): 375-417. DMOG8IE RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3360091/ DMAKWQD DI DMAKWQD DMAKWQD DN EVT100 DMAKWQD MI TTN9D8E DMAKWQD MN Glutamate receptor ionotropic NMDA 2B (NMDAR2B) DMAKWQD MT DTT DMAKWQD MA Antagonist DMAKWQD RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMAKWQD RU http://phrma-docs.phrma.org/files/dmfile/MID_Mental-Illness-2017-Drug-List_Final.pdf DM3VC6T DI DM3VC6T DM3VC6T DN EW-A-401 DM3VC6T MI TT2Q6G1 DM3VC6T MN Vascular endothelial growth factor receptor 1 (FLT-1) DM3VC6T MT DTT DM3VC6T MA Modulator DM3VC6T RN DOI: http://dx.doi.org/10.1016/j.tips.2014.09.007 DM3VC6T RU http://www.cell.com/trends/pharmacological-sciences/fulltext/S0165-6147(14)00160-6 DM2NBC7 DI DM2NBC7 DM2NBC7 DN EZN-2968 DM2NBC7 MI TTQHWNA DM2NBC7 MN Hypoxia-inducible factor 1 alpha (HIF-1A) DM2NBC7 MT DTT DM2NBC7 MA Modulator DM2NBC7 RN Pilot trial of EZN-2968, an antisense oligonucleotide inhibitor of hypoxia-inducible factor-1 alpha (HIF-1), in patients with refractory solid tumors.Cancer Chemother Pharmacol.2014 Feb;73(2):343-8. DM2NBC7 RU https://www.ncbi.nlm.nih.gov/pubmed/24292632 DMXFY18 DI DMXFY18 DMXFY18 DN EZN-3042 DMXFY18 MI TTTPU1G DMXFY18 MN Apoptosis inhibitor survivin (BIRC5) DMXFY18 MT DTT DMXFY18 MA Modulator DMXFY18 RN SPC3042: a proapoptotic survivin inhibitor.Mol Cancer Ther.2008 Sep;7(9):2736-45. DMXFY18 RU https://www.ncbi.nlm.nih.gov/pubmed/18790754 DMNPS59 DI DMNPS59 DMNPS59 DN EZN-4176 DMNPS59 MI TTKPW01 DMNPS59 MN Androgen receptor messenger RNA (AR mRNA) DMNPS59 MT DTT DMNPS59 RN 2011 Pipeline of Santaris Pharma. DMNPS59 RU http://www.santaris.com/product-pipeline DMAH12E DI DMAH12E DMAH12E DN F-15845 DMAH12E MI TTZOVE0 DMAH12E MN Voltage-gated sodium channel alpha Nav1.5 (SCN5A) DMAH12E MT DTT DMAH12E MA Inhibitor DMAH12E RN Selective inhibition of persistent sodium current by F 15845 prevents ischaemia-induced arrhythmias. Br J Pharmacol. 2010 Sep;161(1):79-91. DMAH12E RU https://pubmed.ncbi.nlm.nih.gov/20718741 DML4JXZ DI DML4JXZ DML4JXZ DN F-7TG DML4JXZ MI TTF0EGX DML4JXZ MN Coagulation factor VII (F7) DML4JXZ MT DTT DML4JXZ MA Modulator DML4JXZ RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2363). DML4JXZ RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2363 DM71HLX DI DM71HLX DM71HLX DN FAZ053 DM71HLX MI TT8ZLTI DM71HLX MN Programmed cell death 1 ligand 1 (PD-L1) DM71HLX MT DTT DM71HLX MA Inhibitor DM71HLX RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DM71HLX RU http://phrma-docs.phrma.org/files/dmfile/MID_Immuno-Oncology-2017_Drug-List1.pdf DM13YK0 DI DM13YK0 DM13YK0 DN Ferroportin mab DM13YK0 MI TT6Y1PG DM13YK0 MN Solute carrier family 40 member 1 (SLC40A1) DM13YK0 MT DTT DM13YK0 RN The pathophysiology and pharmacology of hepcidin. Trends Pharmacol Sci. 2014 March; 35(3): 155-161. DM13YK0 RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3978192/ DMS1O56 DI DMS1O56 DMS1O56 DN FF-10101-01 DMS1O56 MI TTGJCWZ DMS1O56 MN Fms-like tyrosine kinase 3 (FLT-3) DMS1O56 MT DTT DMS1O56 MA Inhibitor DMS1O56 RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMS1O56 RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DMX5290 DI DMX5290 DMX5290 DN FF-10502-01 DMX5290 MI TTUBNVO DMX5290 MN DNA synthesis (DNA synth) DMX5290 MT DTT DMX5290 MA Inhibitor DMX5290 RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMX5290 RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DM2GHIP DI DM2GHIP DM2GHIP DN FFC-14A DM2GHIP MI TTUTN1I DM2GHIP MN Human Deoxyribonucleic acid (hDNA) DM2GHIP MT DTT DM2GHIP MA Binder DM2GHIP RN The heterocyclic ruthenium(III) complex KP1019 (FFC14A) causes DNA damage and oxidative stress in colorectal tumor cells. Cancer Lett. 2005 Aug 26;226(2):115-21. DM2GHIP RU https://pubmed.ncbi.nlm.nih.gov/16039951 DM8U2IE DI DM8U2IE DM8U2IE DN FGI-101-1A6 DM8U2IE MI TTHU7JA DM8U2IE MN Tumor susceptibility gene protein 101 (TSG101) DM8U2IE MT DTT DM8U2IE RN ClinicalTrials.gov (NCT01299142) Safety and Pharmacokinetics Study of Human Monoclonal Antibody (FGI-101-1A6). U.S. National Institutes of Health. DM8U2IE RU https://clinicaltrials.gov/ct2/show/NCT01299142 DMY61GX DI DMY61GX DMY61GX DN FGLL DMY61GX MI TTUBJQ3 DMY61GX MN Neural cell adhesion molecule (NCAM) DMY61GX MT DTT DMY61GX MA Modulator DMY61GX RN An NCAM mimetic, FGL, alters hippocampal cellular morphometry in young adult (4 month-old) rats. Neurochem Res. 2013 Jun;38(6):1208-18. DMY61GX RU https://pubmed.ncbi.nlm.nih.gov/23076631 DMLH2Q6 DI DMLH2Q6 DMLH2Q6 DN Figopitant DMLH2Q6 MI TTZPO1L DMLH2Q6 MN Substance-P receptor (TACR1) DMLH2Q6 MT DTT DMLH2Q6 MA Antagonist DMLH2Q6 RN Investigation of figopitant and its metabolites in rat tissue by combining whole-body autoradiography with liquid extraction surface analysis mass spectrometry. Drug Metab Dispos. 2012 Mar;40(3):419-25. DMLH2Q6 RU https://pubmed.ncbi.nlm.nih.gov/22184457 DM2SALJ DI DM2SALJ DM2SALJ DN Flanvotumab DM2SALJ MI TTFRV98 DM2SALJ MN Melanoma antigen gp75 (TYRP1) DM2SALJ MT DTT DM2SALJ RN National Cancer Institute Drug Dictionary (drug id 675217). DM2SALJ RU http://www.cancer.gov/publications/dictionaries/cancer-drug?cdrid=675217 DM7BMD6 DI DM7BMD6 DM7BMD6 DN FN-1501 DM7BMD6 MI TT7HF4W DM7BMD6 MN Cyclin-dependent kinase 2 (CDK2) DM7BMD6 MT DTT DM7BMD6 MA Inhibitor DM7BMD6 RN Discovery of 4-((7H-Pyrrolo[2,3-d]pyrimidin-4-yl)amino)-N-(4-((4-methylpiperazin-1-yl)methyl)phenyl)-1H-pyrazole-3-carboxamide (FN-1501), an FLT3- and CDK-Kinase Inhibitor with Potentially High Efficiency against Acute Myelocytic Leukemia. J Med Chem. 2018 Feb 22;61(4):1499-1518. DM7BMD6 RU https://pubmed.ncbi.nlm.nih.gov/29357250 DM7BMD6 DI DM7BMD6 DM7BMD6 DN FN-1501 DM7BMD6 MI TT0PG8F DM7BMD6 MN Cyclin-dependent kinase 4 (CDK4) DM7BMD6 MT DTT DM7BMD6 MA Inhibitor DM7BMD6 RN Discovery of 4-((7H-Pyrrolo[2,3-d]pyrimidin-4-yl)amino)-N-(4-((4-methylpiperazin-1-yl)methyl)phenyl)-1H-pyrazole-3-carboxamide (FN-1501), an FLT3- and CDK-Kinase Inhibitor with Potentially High Efficiency against Acute Myelocytic Leukemia. J Med Chem. 2018 Feb 22;61(4):1499-1518. DM7BMD6 RU https://pubmed.ncbi.nlm.nih.gov/29357250 DM7BMD6 DI DM7BMD6 DM7BMD6 DN FN-1501 DM7BMD6 MI TTO0FDJ DM7BMD6 MN Cyclin-dependent kinase 6 (CDK6) DM7BMD6 MT DTT DM7BMD6 MA Inhibitor DM7BMD6 RN Discovery of 4-((7H-Pyrrolo[2,3-d]pyrimidin-4-yl)amino)-N-(4-((4-methylpiperazin-1-yl)methyl)phenyl)-1H-pyrazole-3-carboxamide (FN-1501), an FLT3- and CDK-Kinase Inhibitor with Potentially High Efficiency against Acute Myelocytic Leukemia. J Med Chem. 2018 Feb 22;61(4):1499-1518. DM7BMD6 RU https://pubmed.ncbi.nlm.nih.gov/29357250 DM7BMD6 DI DM7BMD6 DM7BMD6 DN FN-1501 DM7BMD6 MI TTGJCWZ DM7BMD6 MN Fms-like tyrosine kinase 3 (FLT-3) DM7BMD6 MT DTT DM7BMD6 MA Inhibitor DM7BMD6 RN Discovery of 4-((7H-Pyrrolo[2,3-d]pyrimidin-4-yl)amino)-N-(4-((4-methylpiperazin-1-yl)methyl)phenyl)-1H-pyrazole-3-carboxamide (FN-1501), an FLT3- and CDK-Kinase Inhibitor with Potentially High Efficiency against Acute Myelocytic Leukemia. J Med Chem. 2018 Feb 22;61(4):1499-1518. DM7BMD6 RU https://pubmed.ncbi.nlm.nih.gov/29357250 DMKX174 DI DMKX174 DMKX174 DN FOR46 DMKX174 MI TTMS7DF DMKX174 MN Membrane cofactor protein (CD46) DMKX174 MT DTT DMKX174 RN Clinical pipeline report, company report or official report of Fortis Therapeutics. DMKX174 RU https://fortistx.com/for46-pipeline/ DMH1NXO DI DMH1NXO DMH1NXO DN FP-025 DMH1NXO MI TTXZ0KQ DMH1NXO MN Matrix metalloproteinase-12 (MMP-12) DMH1NXO MT DTT DMH1NXO MA Inhibitor DMH1NXO RN Potential clinical implications of recent matrix metalloproteinase inhibitor design strategies. Expert Rev Proteomics. 2015;12(5):445-7. DMH1NXO RU https://www.ncbi.nlm.nih.gov/pubmed/26174966 DMV9FTH DI DMV9FTH DMV9FTH DN FP-045 DMV9FTH MI TTFLN4T DMV9FTH MN Mitochondrial aldehyde dehydrogenase (ALDH2) DMV9FTH MT DTT DMV9FTH MA Agonist DMV9FTH RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMV9FTH RU http://phrma-docs.phrma.org/files/dmfile/2018_Heart-Disease-and-Stroke_MID-Drug-List.pdf DM8BG0M DI DM8BG0M DM8BG0M DN FP-253-GDEPT DM8BG0M MI TTVYIH7 DM8BG0M MN Schistosoma Purine nucleoside phosphorylase (sch PNP) DM8BG0M MT DTT DM8BG0M MA Modulator DM8BG0M RN Purine nucleoside phosphorylase and fludarabine phosphate gene-directed enzyme prodrug therapy suppresses primary tumour growth and pseudo-metastases in a mouse model of prostate cancer. J Gene Med. 2004 Dec;6(12):1343-57. DM8BG0M RU https://pubmed.ncbi.nlm.nih.gov/15493036 DM1EBRK DI DM1EBRK DM1EBRK DN FPA144 DM1EBRK MI TTGKIED DM1EBRK MN Fibroblast growth factor-2 (FGF2) DM1EBRK MT DTT DM1EBRK MA Antagonist DM1EBRK RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DM1EBRK RU http://phrma-docs.phrma.org/files/dmfile/MID_Immuno-Oncology-2017_Drug-List1.pdf DMI9A1Z DI DMI9A1Z DMI9A1Z DN FPI-1434 DMI9A1Z MI TTHRID2 DMI9A1Z MN Insulin-like growth factor I receptor (IGF1R) DMI9A1Z MT DTT DMI9A1Z RN Clinical pipeline report, company report or official report of Fusion Pharmaceuticals. DMI9A1Z RU https://fusionpharma.com/fusion-pipeline/ DMUI8F3 DI DMUI8F3 DMUI8F3 DN Friulimicin DMUI8F3 MI TTXT4D5 DMUI8F3 MN Bacterial Cell membrane (Bact CM) DMUI8F3 MT DTT DMUI8F3 MA Inhibitor DMUI8F3 RN Model membrane approaches to determine the role of calcium for the antimicrobial activity of friulimicin. Int J Antimicrob Agents. 2011 Mar;37(3):256-60. DMUI8F3 RU https://pubmed.ncbi.nlm.nih.gov/21306875 DM0QH9K DI DM0QH9K DM0QH9K DN FS118 DM0QH9K MI TTNVXAW DM0QH9K MN Lymphocyte activation gene 3 protein (LAG3) DM0QH9K MT DTT DM0QH9K RN Development of Inhibitors of the Programmed Cell Death-1/Programmed Cell Death-Ligand 1 Signaling Pathway.J Med Chem. 2019 Feb 28;62(4):1715-1730. DM0QH9K RU https://pubmed.ncbi.nlm.nih.gov/30247903 DM0QH9K DI DM0QH9K DM0QH9K DN FS118 DM0QH9K MI TT8ZLTI DM0QH9K MN Programmed cell death 1 ligand 1 (PD-L1) DM0QH9K MT DTT DM0QH9K RN Development of Inhibitors of the Programmed Cell Death-1/Programmed Cell Death-Ligand 1 Signaling Pathway.J Med Chem. 2019 Feb 28;62(4):1715-1730. DM0QH9K RU https://pubmed.ncbi.nlm.nih.gov/30247903 DMPENAL DI DMPENAL DMPENAL DN FSI-189 DMPENAL MI TTBRJS9 DMPENAL MN Inhibitory receptor SHPS-1 (SIRPA) DMPENAL MT DTT DMPENAL RN T cells bring unconventional cancer-targeting to the clinic - again. Nat Biotechnol. 2020 Apr;38(4):389-391. DMPENAL RU https://pubmed.ncbi.nlm.nih.gov/32265560 DMZOAT3 DI DMZOAT3 DMZOAT3 DN FT-1101 DMZOAT3 MI TTE4BSY DMZOAT3 MN Bromodomain and extraterminal domain protein (BET) DMZOAT3 MT DTT DMZOAT3 MA Inhibitor DMZOAT3 RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMZOAT3 RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DMCK3OI DI DMCK3OI DMCK3OI DN FT-7051 DMCK3OI MI TTFRCTK DMCK3OI MN CREB-binding protein (CREBBP) DMCK3OI MT DTT DMCK3OI MA Inhibitor DMCK3OI RN Clinical pipeline report, company report or official report of FORMA Therapeutics. DMCK3OI RU https://www.formatherapeutics.com/programs/metastatic-castration-resistant-prostate-cancer/ DMCK3OI DI DMCK3OI DMCK3OI DN FT-7051 DMCK3OI MI TTGH73N DMCK3OI MN Histone acetyltransferase p300 (EP300) DMCK3OI MT DTT DMCK3OI MA Inhibitor DMCK3OI RN Clinical pipeline report, company report or official report of FORMA Therapeutics. DMCK3OI RU https://www.formatherapeutics.com/programs/metastatic-castration-resistant-prostate-cancer/ DMGJNTQ DI DMGJNTQ DMGJNTQ DN FT-819 DMGJNTQ MI TTW640A DMGJNTQ MN B-lymphocyte surface antigen B4 (CD19) DMGJNTQ MT DTT DMGJNTQ RN Clinical pipeline report, company report or official report of Fate Therapeutics. DMGJNTQ RU https://fatetherapeutics.com/pipeline/immuno-oncology-candidates/ft819/ DML028U DI DML028U DML028U DN G1T28-1 DML028U MI TT0PG8F DML028U MN Cyclin-dependent kinase 4 (CDK4) DML028U MT DTT DML028U MA Modulator DML028U RN Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41. DML028U RU https://www.ncbi.nlm.nih.gov/pubmed/15950434 DML028U DI DML028U DML028U DN G1T28-1 DML028U MI TTO0FDJ DML028U MN Cyclin-dependent kinase 6 (CDK6) DML028U MT DTT DML028U MA Modulator DML028U RN Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41. DML028U RU https://www.ncbi.nlm.nih.gov/pubmed/15950434 DMRGP72 DI DMRGP72 DMRGP72 DN G1T-48 DMRGP72 MI TTZAYWL DMRGP72 MN Estrogen receptor (ESR) DMRGP72 MT DTT DMRGP72 MA Degrader DMRGP72 RN G1T48, an oral selective estrogen receptor degrader, and the CDK4/6 inhibitor lerociclib inhibit tumor growth in animal models of endocrine-resistant breast cancer. Breast Cancer Res Treat. 2020 Apr;180(3):635-646. DMRGP72 RU https://pubmed.ncbi.nlm.nih.gov/32130619 DM3H6YC DI DM3H6YC DM3H6YC DN G-619 DM3H6YC MI TT2O84V DM3H6YC MN Thromboxane A2 receptor (TBXA2R) DM3H6YC MT DTT DM3H6YC MA Modulator DM3H6YC RN G 619, a dual thromboxane synthase inhibitor and thromboxane A2 receptor antagonist, inhibits tumor necrosis factor-alpha biosynthesis. Eur J Pharmacol. 1995 Nov 3;286(1):31-9. DM3H6YC RU https://pubmed.ncbi.nlm.nih.gov/8566149 DM3H6YC DI DM3H6YC DM3H6YC DN G-619 DM3H6YC MI TTKNWZ4 DM3H6YC MN Thromboxane-A synthase (TBXAS1) DM3H6YC MT DTT DM3H6YC MA Modulator DM3H6YC RN G 619, a dual thromboxane synthase inhibitor and thromboxane A2 receptor antagonist, inhibits tumor necrosis factor-alpha biosynthesis. Eur J Pharmacol. 1995 Nov 3;286(1):31-9. DM3H6YC RU https://pubmed.ncbi.nlm.nih.gov/8566149 DMJLIQ2 DI DMJLIQ2 DMJLIQ2 DN GALAMUSTINE HYDROCHLORIDE DMJLIQ2 MI TTUTN1I DMJLIQ2 MN Human Deoxyribonucleic acid (hDNA) DMJLIQ2 MT DTT DMJLIQ2 MA Antagonist DMJLIQ2 RN 6-[Bis(2-chloroethyl)amino]-6-deoxygalactopyranose hydrochloride (C6-galactose mustard), a new alkylating agent with reduced bone marrow toxicity. Cancer Res. 1987 Feb 1;47(3):696-9. DMJLIQ2 RU https://pubmed.ncbi.nlm.nih.gov/3802075 DMG9C4I DI DMG9C4I DMG9C4I DN Galidesivir DMG9C4I MI TTV1095 DMG9C4I MN COVID-19 RNA-directed RNA polymerase (RdRp) DMG9C4I MT DTT DMG9C4I MA Blocker DMG9C4I RN BioCryst Begins Clinical Trial with Galidesivir for Treatment of Patients with COVID-19 DMG9C4I RU https://www.biospace.com/article/releases/biocryst-begins-clinical-trial-with-galidesivir-for-treatment-of-patients-with-covid-19/ DMG9C4I DI DMG9C4I DMG9C4I DN Galidesivir DMG9C4I MI TTOA6YT DMG9C4I MN MERS-CoV RNA-directed RNA polymerase (RdRp) DMG9C4I MT DTT DMG9C4I MA Inhibitor DMG9C4I RN Coronaviruses - drug discovery and therapeutic options. Nat Rev Drug Discov. 2016 May;15(5):327-47. DMG9C4I RU https://pubmed.ncbi.nlm.nih.gov/26868298 DMG9C4I DI DMG9C4I DMG9C4I DN Galidesivir DMG9C4I MI TTKXI53 DMG9C4I MN SARS-CoV RNA-directed RNA polymerase (RdRp) DMG9C4I MT DTT DMG9C4I MA Inhibitor DMG9C4I RN Coronaviruses - drug discovery and therapeutic options. Nat Rev Drug Discov. 2016 May;15(5):327-47. DMG9C4I RU https://pubmed.ncbi.nlm.nih.gov/26868298 DMIXMQE DI DMIXMQE DMIXMQE DN GAP T cells DMIXMQE MI TTJTSX4 DMIXMQE MN Glypican-3 (GPC3) DMIXMQE MT DTT DMIXMQE MA CAR-T-Cell-Therapy DMIXMQE RN ClinicalTrials.gov (NCT02932956) Glypican 3-specific Chimeric Antigen Receptor Expressed in T Cells for Patients With Pediatric Solid Tumors (GAP) DMIXMQE RU https://clinicaltrials.gov/ct2/show/NCT02932956 DM52O7W DI DM52O7W DM52O7W DN GBR1302 DM52O7W MI TT6EO5L DM52O7W MN Erbb2 tyrosine kinase receptor (HER2) DM52O7W MT DTT DM52O7W MA Inhibitor DM52O7W RN Clinical pipeline report, company report or official report of Glenmark Pharmaceuticals. DM52O7W RU https://glenmarkpharma-us.com/wp-content/uploads/GBR-1302_Pharmacology_ASCO-18_-FINAL.pdf DM52O7W DI DM52O7W DM52O7W DN GBR1302 DM52O7W MI TTUN7MC DM52O7W MN T-cell surface glycoprotein CD3 (CD3) DM52O7W MT DTT DM52O7W MA Inhibitor DM52O7W RN Clinical pipeline report, company report or official report of Glenmark Pharmaceuticals. DM52O7W RU https://glenmarkpharma-us.com/wp-content/uploads/GBR-1302_Pharmacology_ASCO-18_-FINAL.pdf DMQBEYV DI DMQBEYV DMQBEYV DN GC021109 DMQBEYV MI TTNVSKA DMQBEYV MN P2Y purinoceptor 6 (P2RY6) DMQBEYV MT DTT DMQBEYV MA Agonist DMQBEYV RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMQBEYV RU http://phrma-docs.phrma.org/files/dmfile/MID_Neurological-Disorders-Drug-List_2018.pdf DM6R4DO DI DM6R4DO DM6R4DO DN GC-1008 DM6R4DO MI TT5BDCY DM6R4DO MN TGF-beta receptor (TGFBR) DM6R4DO MT DTT DM6R4DO MA Modulator DM6R4DO RN Phase I study of GC1008 (fresolimumab): a human anti-transforming growth factor-beta (TGF) monoclonal antibody in patients with advanced malignant melanoma or renal cell carcinoma.PLoS One.2014 Mar 11;9(3):e90353. DM6R4DO RU https://www.ncbi.nlm.nih.gov/pubmed/24618589 DMK96CE DI DMK96CE DMK96CE DN GC-1113 DMK96CE MI TTQG4NR DMK96CE MN Erythropoietin (EPO) DMK96CE MT DTT DMK96CE MA Modulator DMK96CE RN A long-acting erythropoietin fused with noncytolytic human Fc for the treatment of anemia. Arch Pharm Res. 2012 May;35(5):757-9. DMK96CE RU https://pubmed.ncbi.nlm.nih.gov/22644842 DMJ7WRI DI DMJ7WRI DMJ7WRI DN GCC-1290K DMJ7WRI MI TTYVX59 DMJ7WRI MN Protein kinase C (PRKC) DMJ7WRI MT DTT DMJ7WRI MA Modulator DMJ7WRI RN Inhibitory effect of glutamate release from rat cerebrocortical synaptosomes by dextromethorphan and its metabolite 3-hydroxymorphinan. Neurochem Int. 2009 Jul;54(8):526-34. DMJ7WRI RU https://pubmed.ncbi.nlm.nih.gov/19428798 DMJ7WRI DI DMJ7WRI DMJ7WRI DN GCC-1290K DMJ7WRI MI TTCRJKY DMJ7WRI MN Voltage-gated calcium channel (Cav) DMJ7WRI MT DTT DMJ7WRI MA Modulator DMJ7WRI RN Inhibitory effect of glutamate release from rat cerebrocortical synaptosomes by dextromethorphan and its metabolite 3-hydroxymorphinan. Neurochem Int. 2009 Jul;54(8):526-34. DMJ7WRI RU https://pubmed.ncbi.nlm.nih.gov/19428798 DMHMZC7 DI DMHMZC7 DMHMZC7 DN GCC-4401 DMHMZC7 MI TTCIHJA DMHMZC7 MN Coagulation factor Xa (F10) DMHMZC7 MT DTT DMHMZC7 MA Inhibitor DMHMZC7 RN Semuloparin for the prevention of venous thromboembolic events in cancer patients. Drugs Today (Barc). 2012 Jul;48(7):451-7. DMHMZC7 RU https://pubmed.ncbi.nlm.nih.gov/22844656 DM9TD2N DI DM9TD2N DM9TD2N DN GD2 T cells DM9TD2N MI TT80ARU DM9TD2N MN Ganglioside GD2 (GD2) DM9TD2N MT DTT DM9TD2N MA CAR-T-Cell-Therapy DM9TD2N RN ClinicalTrials.gov (NCT01953900) iC9-GD2-CAR-VZV-CTLs/Refractory or Metastatic GD2-positive Sarcoma and Neuroblastoma DM9TD2N RU https://clinicaltrials.gov/ct2/show/NCT01953900 DMSE19U DI DMSE19U DMSE19U DN GDC0134 DMSE19U MI TTF4AVB DMSE19U MN Protein delta homolog 1 (DLK1) DMSE19U MT DTT DMSE19U MA Inhibitor DMSE19U RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMSE19U RU http://phrma-docs.phrma.org/files/dmfile/MID_Neurological-Disorders-Drug-List_2018.pdf DM1B3UM DI DM1B3UM DM1B3UM DN GDC-0152 DM1B3UM MI TTR7B60 DM1B3UM MN X-linked inhibitor of apoptosis protein (XIAP) DM1B3UM MT DTT DM1B3UM MA Modulator DM1B3UM RN Discovery of a potent small-molecule antagonist of inhibitor of apoptosis (IAP) proteins and clinical candidate for the treatment of cancer (GDC-0152). J Med Chem. 2012 May 10;55(9):4101-13. DM1B3UM RU https://pubmed.ncbi.nlm.nih.gov/22413863 DMUNFEP DI DMUNFEP DMUNFEP DN GDC0310 DMUNFEP MI TT4G2JS DMUNFEP MN Voltage-gated sodium channel alpha Nav1.7 (SCN9A) DMUNFEP MT DTT DMUNFEP MA Inhibitor DMUNFEP RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMUNFEP RU http://phrma-docs.phrma.org/files/dmfile/MID_Neurological-Disorders-Drug-List_2018.pdf DM3Z2JB DI DM3Z2JB DM3Z2JB DN GDC-0349 DM3Z2JB MI TTCJG29 DM3Z2JB MN Serine/threonine-protein kinase mTOR (mTOR) DM3Z2JB MT DTT DM3Z2JB MA Inhibitor DM3Z2JB RN Discovery and Biological Profiling of Potent and Selective mTOR Inhibitor GDC-0349. ACS Med Chem Lett. 2012 Nov 29;4(1):103-7. DM3Z2JB RU https://pubmed.ncbi.nlm.nih.gov/24900569 DMDZ26X DI DMDZ26X DMDZ26X DN GDC-0425 DMDZ26X MI TTTU902 DMDZ26X MN Checkpoint kinase-1 (CHK1) DMDZ26X MT DTT DMDZ26X MA Modulator DMDZ26X RN Quantitative assessment of BCL-2:BIM complexes as a pharmacodynamic marker for venetoclax (ABT-199). DMDZ26X RU http://cancerres.aacrjournals.org/content/75/15_Supplement/6 DMDY08K DI DMDY08K DMDY08K DN GDC-0623 DMDY08K MI TTZCRP3 DMDY08K MN ERK activator kinase (MEK) DMDY08K MT DTT DMDY08K MA Inhibitor DMDY08K RN Clinical pipeline report, company report or official report of Genentech (2011). DMDY08K RU http://www.gene.com/gene/index.jsp DMFC2OY DI DMFC2OY DMFC2OY DN GDC-0994 DMFC2OY MI TT1MG9E DMFC2OY MN Extracellular signal-regulated kinase 1 (ERK1) DMFC2OY MT DTT DMFC2OY MA Modulator DMFC2OY RN ERK Mutations Confer Resistance to Mitogen-Activated Protein Kinase Pathway Inhibitors DMFC2OY RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4300142 DMFC2OY DI DMFC2OY DMFC2OY DN GDC-0994 DMFC2OY MI TT4TQBX DMFC2OY MN Extracellular signal-regulated kinase 2 (ERK2) DMFC2OY MT DTT DMFC2OY MA Modulator DMFC2OY RN ERK Mutations Confer Resistance to Mitogen-Activated Protein Kinase Pathway Inhibitors DMFC2OY RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4300142 DMJA27W DI DMJA27W DMJA27W DN GDC-5573 DMJA27W MI TTB18GJ DMJA27W MN Proto-oncogene c-RAF (c-RAF) DMJA27W MT DTT DMJA27W MA Inhibitor DMJA27W RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMJA27W RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DMMF6UB DI DMMF6UB DMMF6UB DN GE-1170A DMMF6UB MI TTYQIFM DMMF6UB MN Staphylococcus Elongation factor Tu (Stap-coc tuf) DMMF6UB MT DTT DMMF6UB MA Inhibitor DMMF6UB RN GE2270A-resistant mutations in elongation factor Tu allow productive aminoacyl-tRNA binding to EF-Tu.GTP.GE2270A complexes. J Mol Biol. 2000 Dec 15;304(5):995-1005. DMMF6UB RU https://pubmed.ncbi.nlm.nih.gov/11124042 DMJK7V0 DI DMJK7V0 DMJK7V0 DN Ge2270a DMJK7V0 MI TTG45NU DMJK7V0 MN Plasmodium Elongation factor 1-alpha 1 (Malaria MEF-1) DMJK7V0 MT DTT DMJK7V0 MA Inhibitor DMJK7V0 RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMJK7V0 RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMDMKVL DI DMDMKVL DMDMKVL DN GEM333 DMDMKVL MI TTJVYO3 DMDMKVL MN Myeloid cell surface antigen CD33 (CD33) DMDMKVL MT DTT DMDMKVL MA Inhibitor DMDMKVL RN Clinical pipeline report, company report or official report of Gemoab. DMDMKVL RU https://www.gemoab.com/gem333 DMDMKVL DI DMDMKVL DMDMKVL DN GEM333 DMDMKVL MI TTUN7MC DMDMKVL MN T-cell surface glycoprotein CD3 (CD3) DMDMKVL MT DTT DMDMKVL MA Inhibitor DMDMKVL RN Clinical pipeline report, company report or official report of Gemoab. DMDMKVL RU https://www.gemoab.com/gem333 DM3GSPR DI DM3GSPR DM3GSPR DN GEM3PSCA DM3GSPR MI TT9T4AV DM3GSPR MN Prostate stem cell antigen (PSCA) DM3GSPR MT DTT DM3GSPR MA Inhibitor DM3GSPR RN Clinical pipeline report, company report or official report of Gemoab. DM3GSPR RU https://www.gemoab.com/gem3psca DMV8IWJ DI DMV8IWJ DMV8IWJ DN GEN1029 DMV8IWJ MI TTW20TU DMV8IWJ MN TRAIL receptor 2 (TRAIL-R2) DMV8IWJ MT DTT DMV8IWJ MA Agonist DMV8IWJ RN National Cancer Institute Drug Dictionary (drug name Tilogotamab). DMV8IWJ RU https://www.cancer.gov/publications/dictionaries/cancer-drug/def/tilogotamab DMNP6T3 DI DMNP6T3 DMNP6T3 DN GEN1042 DMNP6T3 MI TTN6Y9A DMNP6T3 MN CD40L receptor (CD40) DMNP6T3 MT DTT DMNP6T3 MA Agonist DMNP6T3 RN Clinical pipeline report, company report or official report of Genmab. DMNP6T3 RU https://www.genmab.com/pipeline/ DMNP6T3 DI DMNP6T3 DMNP6T3 DN GEN1042 DMNP6T3 MI TTPW9LJ DMNP6T3 MN Co-stimulatory molecule 4-1BB (CD137) DMNP6T3 MT DTT DMNP6T3 MA Agonist DMNP6T3 RN Clinical pipeline report, company report or official report of Genmab. DMNP6T3 RU https://www.genmab.com/pipeline/ DMQ9317 DI DMQ9317 DMQ9317 DN GEN1044 DMQ9317 MI TT70MLA DMQ9317 MN Oncotrophoblast glycoprotein 5T4 (TPBG) DMQ9317 MT DTT DMQ9317 RN Clinical pipeline report, company report or official report of AbbVie. DMQ9317 RU https://www.abbvie.com/our-science/pipeline/gen-1044.html DMQ9317 DI DMQ9317 DMQ9317 DN GEN1044 DMQ9317 MI TTUN7MC DMQ9317 MN T-cell surface glycoprotein CD3 (CD3) DMQ9317 MT DTT DMQ9317 RN Clinical pipeline report, company report or official report of AbbVie. DMQ9317 RU https://www.abbvie.com/our-science/pipeline/gen-1044.html DMEWRNZ DI DMEWRNZ DMEWRNZ DN GEN1046 DMEWRNZ MI TTPW9LJ DMEWRNZ MN Co-stimulatory molecule 4-1BB (CD137) DMEWRNZ MT DTT DMEWRNZ MA Agonist DMEWRNZ RN Clinical pipeline report, company report or official report of Genmab. DMEWRNZ RU https://www.genmab.com/pipeline/ DMEWRNZ DI DMEWRNZ DMEWRNZ DN GEN1046 DMEWRNZ MI TT8ZLTI DMEWRNZ MN Programmed cell death 1 ligand 1 (PD-L1) DMEWRNZ MT DTT DMEWRNZ MA Agonist DMEWRNZ RN Clinical pipeline report, company report or official report of Genmab. DMEWRNZ RU https://www.genmab.com/pipeline/ DMWR93D DI DMWR93D DMWR93D DN Genaconazole DMWR93D MI TTTSOUD DMWR93D MN Candida Cytochrome P450 51 (Candi ERG11) DMWR93D MT DTT DMWR93D MA Modulator DMWR93D RN New targets and delivery systems for antifungal therapy. Med Mycol. 2000;38 Suppl 1:335-47. DMWR93D RU https://pubmed.ncbi.nlm.nih.gov/11204162 DMJP83V DI DMJP83V DMJP83V DN Gene therapy, IFN-b DMJP83V MI TT4TZ8J DMJP83V MN Interferon-beta (IFNB1) DMJP83V MT DTT DMJP83V MA Modulator DMJP83V RN Interferon-beta gene therapy for cancer: basic research to clinical application. Cancer Sci. 2004 Nov;95(11):858-65. DMJP83V RU https://pubmed.ncbi.nlm.nih.gov/15546502 DMTGN0U DI DMTGN0U DMTGN0U DN Genz 644282 DMTGN0U MI DTUGYRD DMTGN0U MN P-glycoprotein 1 (ABCB1) DMTGN0U MT DTP DMTGN0U MA Substrate DMTGN0U RN Molecular and cellular pharmacology of the novel noncamptothecin topoisomerase I inhibitor Genz-644282. Mol Cancer Ther. 2011 Aug;10(8):1490-9. DMTGN0U RU https://doi.org/10.1158/1535-7163.MCT-10-1043 DMIXABW DI DMIXABW DMIXABW DN Genz-644282 DMIXABW MI TTGTQHC DMIXABW MN DNA topoisomerase I (TOP1) DMIXABW MT DTT DMIXABW MA Inhibitor DMIXABW RN Genz-644282, a novel non-camptothecin topoisomerase I inhibitor for cancer treatment. Clin Cancer Res. 2011 May 1;17(9):2777-87. DMIXABW RU https://pubmed.ncbi.nlm.nih.gov/21415217 DMA9UX2 DI DMA9UX2 DMA9UX2 DN Gerilimzumab DMA9UX2 MI TTT1V78 DMA9UX2 MN Interleukin-6 (IL6) DMA9UX2 MT DTT DMA9UX2 RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMA9UX2 RU http://phrma-docs.phrma.org/files/dmfile/medicines-in-development-drug-list-autoimmune-diseases.pdf DMDMPKC DI DMDMPKC DMDMPKC DN GGF-2 DMDMPKC MI TTEH395 DMDMPKC MN Pro-neuregulin-1 (Pro-NRG1) DMDMPKC MT DTT DMDMPKC MA Modulator DMDMPKC RN Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41. DMDMPKC RU https://www.ncbi.nlm.nih.gov/pubmed/15950434 DM8U23L DI DM8U23L DM8U23L DN GGTI-2418 DM8U23L MI TTXQKM3 DM8U23L MN Farnesyl protein transferase (Ftase) DM8U23L MT DTT DM8U23L MA Modulator DM8U23L RN Company report (Prescient) DM8U23L RU http://prescienttherapeutics.com/ptx-100/ DMKY1L4 DI DMKY1L4 DMKY1L4 DN Glucose-6-phosphate DMKY1L4 MI TTC67I0 DMKY1L4 MN Bacterial Glucosamine-6-phosphate synthase (Bact glmS) DMKY1L4 MT DTT DMKY1L4 MA Inhibitor DMKY1L4 RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMKY1L4 RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMKY1L4 DI DMKY1L4 DMKY1L4 DN Glucose-6-phosphate DMKY1L4 MI DTLHZFU DMKY1L4 MN Glucose-6-phosphate translocase (SLC37A4) DMKY1L4 MT DTP DMKY1L4 MA Substrate DMKY1L4 RN A novel mutation (A148V) in the glucose 6-phosphate translocase (SLC37A4) gene in a Korean patient with glycogen storage disease type 1b. J Korean Med Sci. 2005 Jun;20(3):499-501. DMKY1L4 RU http://www.ncbi.nlm.nih.gov/pubmed/15953877 DMKY1L4 DI DMKY1L4 DMKY1L4 DN Glucose-6-phosphate DMKY1L4 MI DTH9SQJ DMKY1L4 MN Glycerol-3-phosphate permease (SLC37A1) DMKY1L4 MT DTP DMKY1L4 MA Substrate DMKY1L4 RN SLC37A1 and SLC37A2 are phosphate-linked, glucose-6-phosphate antiporters. PLoS One. 2011;6(9):e23157. DMKY1L4 RU http://www.ncbi.nlm.nih.gov/pubmed/21949678 DM1PK0T DI DM1PK0T DM1PK0T DN GLYCAR T cells DM1PK0T MI TTJTSX4 DM1PK0T MN Glypican-3 (GPC3) DM1PK0T MT DTT DM1PK0T MA CAR-T-Cell-Therapy DM1PK0T RN ClinicalTrials.gov (NCT02905188) Glypican 3-specific Chimeric Antigen Receptor Expressing T Cells for Hepatocellular Carcinoma (GLYCAR) DM1PK0T RU https://clinicaltrials.gov/ct2/show/NCT02905188 DMCKZUT DI DMCKZUT DMCKZUT DN GlyT1 PET radiotracers DMCKZUT MI TTHJTF7 DMCKZUT MN Glycine transporter GlyT-1 (SLC6A9) DMCKZUT MT DTT DMCKZUT MA Modulator DMCKZUT RN Glycine Transport Inhibitors for the Treatment of Schizophrenia. Open Med Chem J. 2010; 4: 10-19. DMCKZUT RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3023951/ DML1KSA DI DML1KSA DML1KSA DN GMI-1359 DML1KSA MI TTBID49 DML1KSA MN C-X-C chemokine receptor type 4 (CXCR4) DML1KSA MT DTT DML1KSA MA Antagonist DML1KSA RN Clinical pipeline report, company report or official report of GlycoMimetics. DML1KSA RU http://glycomimetics.com/pipeline/programs/gmi-1359/ DML1KSA DI DML1KSA DML1KSA DN GMI-1359 DML1KSA MI TTAU4D6 DML1KSA MN E-selectin (SELE) DML1KSA MT DTT DML1KSA MA Antagonist DML1KSA RN Clinical pipeline report, company report or official report of GlycoMimetics. DML1KSA RU http://glycomimetics.com/pipeline/programs/gmi-1359/ DMIFSN2 DI DMIFSN2 DMIFSN2 DN GMX1777 DMIFSN2 MI TTD1WIG DMIFSN2 MN Nicotinamide phosphoribosyltransferase (NAMPT) DMIFSN2 MT DTT DMIFSN2 MA Modulator DMIFSN2 RN The small molecule GMX1778 is a potent inhibitor of NAD+ biosynthesis: strategy for enhanced therapy in nicotinic acid phosphoribosyltransferase 1-... Mol Cell Biol. 2009 Nov;29(21):5872-88. DMIFSN2 RU https://pubmed.ncbi.nlm.nih.gov/19703994 DMD6H8B DI DMD6H8B DMD6H8B DN GMZ-2 DMD6H8B MI TT3J5ZI DMD6H8B MN Cell mediated immunity response (CMIR) DMD6H8B MT DTT DMD6H8B RN Immunogenicity of a virosomally-formulated Plasmodium falciparum GLURP-MSP3 chimeric protein-based malaria vaccine candidate in comparison to adjuvanted formulations. Malar J. 2011; 10: 359. DMD6H8B RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3265551/ DMURO94 DI DMURO94 DMURO94 DN GNE Lipoplex DMURO94 MI TT4DP5S DMURO94 MN N-acetylmannosamine kinase (GNE) DMURO94 MT DTT DMURO94 MA Inhibitor DMURO94 RN Hereditary inclusion body myopathy: single patient response to intravenous dosing of GNE gene lipoplex. Hum Gene Ther. 2011 Nov;22(11):1331-41. DMURO94 RU https://pubmed.ncbi.nlm.nih.gov/21517694 DMYWDT4 DI DMYWDT4 DMYWDT4 DN GNKG-168 DMYWDT4 MI TTSHG0T DMYWDT4 MN Toll-like receptor 9 (TLR9) DMYWDT4 MT DTT DMYWDT4 MA Modulator DMYWDT4 RN National Cancer Institute Drug Dictionary (drug id 662816). DMYWDT4 RU http://www.cancer.gov/publications/dictionaries/cancer-drug?cdrid=662816 DMKMU2S DI DMKMU2S DMKMU2S DN GNX102 DMKMU2S MI TTZUFEL DMKMU2S MN Tumor-associated glycan antigen (TAGA) DMKMU2S MT DTT DMKMU2S RN Clinical pipeline report, company report or official report of GlycoNex. DMKMU2S RU http://www.glyconex.com.tw/index.php/en-us/product-pipeline-us DM035LO DI DM035LO DM035LO DN GP-3269 DM035LO MI TTL732K DM035LO MN Adenosine kinase (ADK) DM035LO MT DTT DM035LO MA Inhibitor DM035LO RN Adenosine kinase inhibitors. 6. Synthesis, water solubility, and antinociceptive activity of 5-phenyl-7-(5-deoxy-beta-D-ribofuranosyl)pyrrolo[2,3-d]pyrimidines substituted at C4 with glycinamides andrelated compounds. J Med Chem. 2005 Dec 1;48(24):7808-20. DM035LO RU https://pubmed.ncbi.nlm.nih.gov/16302820 DM9JV80 DI DM9JV80 DM9JV80 DN Gp41 HIV-1 vaccine DM9JV80 MI TTG90S6 DM9JV80 MN Human immunodeficiency virus Glycoprotein 41 (HIV gp41) DM9JV80 MT DTT DM9JV80 MA Modulator DM9JV80 RN Phase 1 safety and immunogenicity evaluation of ADVAX, a multigenic, DNA-based clade C/B' HIV-1 candidate vaccine. PLoS One. 2010 Jan 25;5(1):e8617. DM9JV80 RU https://pubmed.ncbi.nlm.nih.gov/20111582 DM2MILF DI DM2MILF DM2MILF DN GPA-TriMAR-T cells DM2MILF MI TT9VL2N DM2MILF MN Gp100[209-217] peptide (PMEL) DM2MILF MT DTT DM2MILF MA CAR-T-Cell-Therapy DM2MILF RN ClinicalTrials.gov (NCT03649529) Treatment of Malignant Melanoma With GPA-TriMAR-T Cell Therapy DM2MILF RU https://clinicaltrials.gov/ct2/show/NCT03649529 DMVWHS1 DI DMVWHS1 DMVWHS1 DN GPC3 targeting CAR-T cells DMVWHS1 MI TTJTSX4 DMVWHS1 MN Glypican-3 (GPC3) DMVWHS1 MT DTT DMVWHS1 MA CAR-T-Cell-Therapy DMVWHS1 RN ClinicalTrials.gov (NCT03198546) GPC3-T2-CAR-T Cells for Immunotherapy of Cancer With GPC3 Expression DMVWHS1 RU https://clinicaltrials.gov/ct2/show/NCT03198546 DM0ZQ48 DI DM0ZQ48 DM0ZQ48 DN GPI-16072 DM0ZQ48 MI TT9G4N0 DM0ZQ48 MN Glutamate carboxypeptidase II (GCPII) DM0ZQ48 MT DTT DM0ZQ48 MA Inhibitor DM0ZQ48 RN Emerging drugs in neuropathic pain. Expert Opin Emerg Drugs. 2007 Mar;12(1):113-26. DM0ZQ48 RU https://pubmed.ncbi.nlm.nih.gov/17355217 DM8MGSH DI DM8MGSH DM8MGSH DN GPRC5D CAR-T cell therapy DM8MGSH MI TTHRAPJ DM8MGSH MN G-protein coupled receptor C 5D (GPRC5D) DM8MGSH MT DTT DM8MGSH RN GPRC5D is a target for the immunotherapy of multiple myeloma with rationally designed CAR T cells. Sci Transl Med. 2019 Mar 27;11(485):eaau7746. DM8MGSH RU https://pubmed.ncbi.nlm.nih.gov/30918115 DMFA2XQ DI DMFA2XQ DMFA2XQ DN GQ1001 DMFA2XQ MI TT6EO5L DMFA2XQ MN Erbb2 tyrosine kinase receptor (HER2) DMFA2XQ MT DTT DMFA2XQ RN Clinical pipeline report, company report or official report of GeneQuantum Healthcare. DMFA2XQ RU http://www.genequantum.com/#/common/product?pid=12&id=13&type=7 DMZ0D3V DI DMZ0D3V DMZ0D3V DN GRC-6211 DMZ0D3V MI TT0IHXV DMZ0D3V MN DNA topoisomerase II (TOP2) DMZ0D3V MT DTT DMZ0D3V MA Inhibitor DMZ0D3V RN Activity of fluoroquinolone antibiotics against Plasmodium falciparum in vitro. Antimicrob Agents Chemother. 1988 Aug;32(8):1182-6. DMZ0D3V RU https://pubmed.ncbi.nlm.nih.gov/2847647 DMZ0D3V DI DMZ0D3V DMZ0D3V DN GRC-6211 DMZ0D3V MI TTMI6F5 DMZ0D3V MN Transient receptor potential cation channel V1 (TRPV1) DMZ0D3V MT DTT DMZ0D3V MA Antagonist DMZ0D3V RN GRC-6211, a new oral specific TRPV1 antagonist, decreases bladder overactivity and noxious bladder input in cystitis animal models. J Urol. 2009 Jan;181(1):379-86. DMZ0D3V RU https://pubmed.ncbi.nlm.nih.gov/19010489 DMGF71W DI DMGF71W DMGF71W DN GRN163 DMGF71W MI TTUJFD0 DMGF71W MN Telomerase reverse transcriptase (TERT) DMGF71W MT DTT DMGF71W MA Inhibitor DMGF71W RN Emerging therapies for multiple myeloma. Expert Opin Emerg Drugs. 2009 Mar;14(1):99-127. DMGF71W RU https://pubmed.ncbi.nlm.nih.gov/19249983 DMI319T DI DMI319T DMI319T DN GS 9667 DMI319T MI TTK25J1 DMI319T MN Adenosine A1 receptor (ADORA1) DMI319T MT DTT DMI319T MA Agonist DMI319T RN Reduction of free fatty acids, safety, and pharmacokinetics of oral GS-9667, an A(1) adenosine receptor partial agonist. J Clin Pharmacol. 2013 Apr;53(4):385-92. DMI319T RU https://pubmed.ncbi.nlm.nih.gov/23427000 DMS25DL DI DMS25DL DMS25DL DN GS-1423 DMS25DL MI TTK0O6Y DMS25DL MN Ecto-5'-nucleotidase (CD73) DMS25DL MT DTT DMS25DL RN Clinical pipeline report, company report or official report of Agenus. DMS25DL RU https://agenusbio.com/pipeline/ DMS25DL DI DMS25DL DMS25DL DN GS-1423 DMS25DL MI TTO3HT7 DMS25DL MN Transforming growth factor beta (TGFB) DMS25DL MT DTT DMS25DL RN Clinical pipeline report, company report or official report of Agenus. DMS25DL RU https://agenusbio.com/pipeline/ DMZVFOQ DI DMZVFOQ DMZVFOQ DN GS-5829 DMZVFOQ MI TTE4BSY DMZVFOQ MN Bromodomain and extraterminal domain protein (BET) DMZVFOQ MT DTT DMZVFOQ MA Inhibitor DMZVFOQ RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMZVFOQ RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DMRDNPC DI DMRDNPC DMRDNPC DN GS-6620 DMRDNPC MI TTMVBWH DMRDNPC MN Hepatitis C virus RNA-directed RNA polymerase (HCV NS5B) DMRDNPC MT DTT DMRDNPC MA Inhibitor DMRDNPC RN Inhibition of hepatitis C virus replication by GS-6620, a potent C-nucleoside monophosphate prodrug. Antimicrob Agents Chemother. 2014;58(4):1930-42. DMRDNPC RU https://pubmed.ncbi.nlm.nih.gov/24419349 DMXG3T1 DI DMXG3T1 DMXG3T1 DN GS-6637 DMXG3T1 MI TTFLN4T DMXG3T1 MN Mitochondrial aldehyde dehydrogenase (ALDH2) DMXG3T1 MT DTT DMXG3T1 MA Inhibitor DMXG3T1 RN Clinical pipeline report, company report or official report of Gilead. DMXG3T1 RU http://www.gilead.com/~/media/Files/pdfs/other/Gilead_Sciences_Company_Overview_FactSheet_080514.pdf DMNX3US DI DMNX3US DMNX3US DN GS-9820 DMNX3US MI TTGBPJE DMNX3US MN PI3-kinase delta (PIK3CD) DMNX3US MT DTT DMNX3US MA Inhibitor DMNX3US RN National Cancer Institute Drug Dictionary (drug id 741949). DMNX3US RU http://www.cancer.gov/publications/dictionaries/cancer-drug?cdrid=741949 DMMF5IE DI DMMF5IE DMMF5IE DN GS-9883 DMMF5IE MI DE4LYSA DMMF5IE MN Cytochrome P450 3A4 (CYP3A4) DMMF5IE MT DME DMMF5IE MA Metabolism DMMF5IE RN Bictegravir, a novel integrase inhibitor for the treatment of HIV infection. Drugs Today (Barc). 2019 Nov;55(11):669-682. DMMF5IE RU https://www.ncbi.nlm.nih.gov/pubmed/?term=31840682 DMMF5IE DI DMMF5IE DMMF5IE DN GS-9883 DMMF5IE MI DEYGVN4 DMMF5IE MN UDP-glucuronosyltransferase 1A1 (UGT1A1) DMMF5IE MT DME DMMF5IE MA Metabolism DMMF5IE RN Bictegravir, a novel integrase inhibitor for the treatment of HIV infection. Drugs Today (Barc). 2019 Nov;55(11):669-682. DMMF5IE RU https://www.ncbi.nlm.nih.gov/pubmed/?term=31840682 DMGHN98 DI DMGHN98 DMGHN98 DN GS-9901 DMGHN98 MI TTGBPJE DMGHN98 MN PI3-kinase delta (PIK3CD) DMGHN98 MT DTT DMGHN98 MA Inhibitor DMGHN98 RN Clinical pipeline report, company report or official report of Gilead. DMGHN98 RU http://www.gilead.com/research/pipeline DMSR5HD DI DMSR5HD DMSR5HD DN GSI-136 DMSR5HD MI TT9W8GU DMSR5HD MN Gamma-secretase (GS) DMSR5HD MT DTT DMSR5HD MA Modulator DMSR5HD RN Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41. DMSR5HD RU https://www.ncbi.nlm.nih.gov/pubmed/15950434 DMO87YS DI DMO87YS DMO87YS DN GSK065 DMO87YS MI TTIY56R DMO87YS MN Kynurenine 3-hydroxylase (KMO) DMO87YS MT DTT DMO87YS MA Inhibitor DMO87YS RN Structural and mechanistic basis of differentiated inhibitors of the acute pancreatitis target kynurenine-3-monooxygenase. Nat Commun. 2017 Jun 12;8:15827. DMO87YS RU https://pubmed.ncbi.nlm.nih.gov/28604669 DMXRPT6 DI DMXRPT6 DMXRPT6 DN GSK1070916 DMXRPT6 MI TT5LS6T DMXRPT6 MN Aurora kinase B (AURKB) DMXRPT6 MT DTT DMXRPT6 MA Modulator DMXRPT6 RN Discovery of GSK1070916, a potent and selective inhibitor of Aurora B/C kinase. J Med Chem. 2010 May 27;53(10):3973-4001. DMXRPT6 RU https://pubmed.ncbi.nlm.nih.gov/20420387 DMXRPT6 DI DMXRPT6 DMXRPT6 DN GSK1070916 DMXRPT6 MI TTLYXIT DMXRPT6 MN Aurora kinase C (AURKC) DMXRPT6 MT DTT DMXRPT6 MA Modulator DMXRPT6 RN Discovery of GSK1070916, a potent and selective inhibitor of Aurora B/C kinase. J Med Chem. 2010 May 27;53(10):3973-4001. DMXRPT6 RU https://pubmed.ncbi.nlm.nih.gov/20420387 DMCJUI9 DI DMCJUI9 DMCJUI9 DN GSK1070916A DMCJUI9 MI TT5LS6T DMCJUI9 MN Aurora kinase B (AURKB) DMCJUI9 MT DTT DMCJUI9 MA Modulator DMCJUI9 RN Discovery of GSK1070916, a potent and selective inhibitor of Aurora B/C kinase. J Med Chem. 2010 May 27;53(10):3973-4001. DMCJUI9 RU https://pubmed.ncbi.nlm.nih.gov/20420387 DMCJUI9 DI DMCJUI9 DMCJUI9 DN GSK1070916A DMCJUI9 MI TTLYXIT DMCJUI9 MN Aurora kinase C (AURKC) DMCJUI9 MT DTT DMCJUI9 MA Modulator DMCJUI9 RN Discovery of GSK1070916, a potent and selective inhibitor of Aurora B/C kinase. J Med Chem. 2010 May 27;53(10):3973-4001. DMCJUI9 RU https://pubmed.ncbi.nlm.nih.gov/20420387 DMK3S9J DI DMK3S9J DMK3S9J DN GSK1144814 DMK3S9J MI TTBPGLU DMK3S9J MN Neuromedin-K receptor (TACR3) DMK3S9J MT DTT DMK3S9J MA Modulator DMK3S9J RN Pharmacokinetics and central nervous system effects of the novel dual NK1 /NK3 receptor antagonist GSK1144814 in alcohol-intoxicated volunteers.Br J Clin Pharmacol.2013 May;75(5):1328-39. DMK3S9J RU https://www.ncbi.nlm.nih.gov/pubmed/23067311 DMK3S9J DI DMK3S9J DMK3S9J DN GSK1144814 DMK3S9J MI TTZPO1L DMK3S9J MN Substance-P receptor (TACR1) DMK3S9J MT DTT DMK3S9J MA Modulator DMK3S9J RN Pharmacokinetics and central nervous system effects of the novel dual NK1 /NK3 receptor antagonist GSK1144814 in alcohol-intoxicated volunteers.Br J Clin Pharmacol.2013 May;75(5):1328-39. DMK3S9J RU https://www.ncbi.nlm.nih.gov/pubmed/23067311 DMNYGB8 DI DMNYGB8 DMNYGB8 DN GSK-1322888 DMNYGB8 MI TT953CX DMNYGB8 MN Motilin receptor (MLNR) DMNYGB8 MT DTT DMNYGB8 MA Agonist DMNYGB8 RN ClinicalTrials.gov (NCT01294566) FTIH to Evaluate Safety, Tolerability, and Pharmacokinetics of Single Oral Doses of GSK1322888 in Healthy Caucasian and Japanese Volunteers. U.S. National Institutes of Health. DMNYGB8 RU https://clinicaltrials.gov/ct2/show/NCT01294566 DMZC9XU DI DMZC9XU DMZC9XU DN GSK-1360707 DMZC9XU MI TTVBI8W DMZC9XU MN Dopamine transporter (DAT) DMZC9XU MT DTT DMZC9XU MA Inhibitor DMZC9XU RN Monoamine transporter occupancy of a novel triple reuptake inhibitor in baboons and humans using positron emission tomography. J Pharmacol Exp Ther. 2013 Aug;346(2):311-7. DMZC9XU RU https://pubmed.ncbi.nlm.nih.gov/23685546 DMZC9XU DI DMZC9XU DMZC9XU DN GSK-1360707 DMZC9XU MI TTAWNKZ DMZC9XU MN Norepinephrine transporter (NET) DMZC9XU MT DTT DMZC9XU MA Inhibitor DMZC9XU RN Monoamine transporter occupancy of a novel triple reuptake inhibitor in baboons and humans using positron emission tomography. J Pharmacol Exp Ther. 2013 Aug;346(2):311-7. DMZC9XU RU https://pubmed.ncbi.nlm.nih.gov/23685546 DMZC9XU DI DMZC9XU DMZC9XU DN GSK-1360707 DMZC9XU MI TT3ROYC DMZC9XU MN Serotonin transporter (SERT) DMZC9XU MT DTT DMZC9XU MA Inhibitor DMZC9XU RN Monoamine transporter occupancy of a novel triple reuptake inhibitor in baboons and humans using positron emission tomography. J Pharmacol Exp Ther. 2013 Aug;346(2):311-7. DMZC9XU RU https://pubmed.ncbi.nlm.nih.gov/23685546 DMEJMTR DI DMEJMTR DMEJMTR DN GSK1440115 DMEJMTR MI TTW5UDX DMEJMTR MN Urotensin II receptor (UTS2R) DMEJMTR MT DTT DMEJMTR MA Antagonist DMEJMTR RN Effects of Urotensin II Receptor Antagonist, GSK1440115, in Asthma. Front Pharmacol. 2013; 4: 54. DMEJMTR RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3638148/ DMWDQOV DI DMWDQOV DMWDQOV DN GSK1482160 DMWDQOV MI TT473XN DMWDQOV MN P2X purinoceptor 7 (P2RX7) DMWDQOV MT DTT DMWDQOV MA Antagonist DMWDQOV RN Clinical pipeline report, company report or official report of GlaxoSmithKline (2009). DMWDQOV RU http://www.gsk.com/investors/product_pipeline/docs/gsk-pipeline-feb09.pdf DM2L7TH DI DM2L7TH DM2L7TH DN GSK1521498 DM2L7TH MI TTKWM86 DM2L7TH MN Opioid receptor mu (MOP) DM2L7TH MT DTT DM2L7TH MA Agonist DM2L7TH RN Clinical pipeline report, company report or official report of GlaxoSmithKline (2009). DM2L7TH RU http://www.gsk.com/investors/product_pipeline/docs/gsk-pipeline-feb09.pdf DM7I1AQ DI DM7I1AQ DM7I1AQ DN GSK1614235 DM7I1AQ MI TT2UE56 DM7I1AQ MN Sodium/glucose cotransporter 1 (SGLT1) DM7I1AQ MT DTT DM7I1AQ MA Blocker DM7I1AQ RN Clinical pipeline report, company report or official report of GlaxoSmithKline (2009). DM7I1AQ RU http://www.gsk.com/investors/product_pipeline/docs/gsk-pipeline-feb09.pdf DMC6QE4 DI DMC6QE4 DMC6QE4 DN GSK1795091 DMC6QE4 MI TTISGCA DMC6QE4 MN Toll-like receptor 4 (TLR4) DMC6QE4 MT DTT DMC6QE4 MA Agonist DMC6QE4 RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMC6QE4 RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DMA41JD DI DMA41JD DMA41JD DN GSK-1827771 DMA41JD MI TT51DEV DMA41JD MN Interleukin 1 receptor type 2 (IL1R2) DMA41JD MT DTT DMA41JD RN WO patent application no. 2013,0077,63, Modulators of the nlrp3 inflammasome il-1ss pathway for the prevention and treatment of acne. DMA41JD RU http://worldwide.espacenet.com/publicationDetails/biblio?DB=worldwide.espacenet.com&II=0&ND=3&adjacent=true&locale=en_EP&FT=D&date=20130117&CC=WO&NR=2013007763A1&KC=A1 DMC14KV DI DMC14KV DMC14KV DN GSK1995057 DMC14KV MI TTG043C DMC14KV MN Tumor necrosis factor receptor type I (TNF-R1) DMC14KV MT DTT DMC14KV RN Autoantibodies to variable heavy (VH) chain Ig sequences in humans impact the safety and clinical pharmacology of a VH domain antibody antagonist of TNF-alpha receptor 1. J Clin Immunol. 2013 Oct;33(7):1192-203. DMC14KV RU https://pubmed.ncbi.nlm.nih.gov/23832582 DMRU4YV DI DMRU4YV DMRU4YV DN GSK-2018682 DMRU4YV MI TT9JZCK DMRU4YV MN Sphingosine-1-phosphate receptor 1 (S1PR1) DMRU4YV MT DTT DMRU4YV MA Agonist DMRU4YV RN Targeting the sphingosine-1-phosphate axis in cancer, inflammation and beyond. Nat Rev Drug Discov. 2013 Sep;12(9):688-702. DMRU4YV RU https://pubmed.ncbi.nlm.nih.gov/23954895 DMM7ZXR DI DMM7ZXR DMM7ZXR DN GSK2126458 DMM7ZXR MI TTHBTOP DMM7ZXR MN PI3-kinase gamma (PIK3CG) DMM7ZXR MT DTT DMM7ZXR MA Modulator DMM7ZXR RN Company report (GSK) DMM7ZXR RU http://www.gsk-clinicalstudyregister.com/study/113794#ps DMRXW9P DI DMRXW9P DMRXW9P DN GSK-2130579A DMRXW9P MI TTZ8UT4 DMRXW9P MN Wilms tumor protein (WT1) DMRXW9P MT DTT DMRXW9P RN Spoilight on personalized medicine. A pharma matters report, Thomson Reuters, 2012. DMRXW9P RU http://science.thomsonreuters.com.cn/media/spotlight_on_report_Q22012.pdf DMUNVXR DI DMUNVXR DMUNVXR DN GSK-2239633 DMUNVXR MI TT7HQD0 DMUNVXR MN C-C chemokine receptor type 4 (CCR4) DMUNVXR MT DTT DMUNVXR MA Antagonist DMUNVXR RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 61). DMUNVXR RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=61 DM5VS7B DI DM5VS7B DM5VS7B DN GSK-2241658A DM5VS7B MI TTE5ITK DM5VS7B MN Cancer/testis antigen 1 (NY-ESO-1) DM5VS7B MT DTT DM5VS7B RN ClinicalTrials.gov (NCT01213472) Evaluation of a New Anti-cancer Immunotherapy in Patients With Non-operable and Progressing Metastatic Cutaneous Melanoma. U.S. National Institutes of Health. DM5VS7B RU https://clinicaltrials.gov/ct2/show/NCT01213472 DMR24MI DI DMR24MI DMR24MI DN GSK-2256098 DMR24MI MI TTON5IT DMR24MI MN Focal adhesion kinase 1 (FAK) DMR24MI MT DTT DMR24MI MA Inhibitor DMR24MI RN A small molecule FAK kinase inhibitor, GSK2256098, inhibits growth and survival of pancreatic ductal adenocarcinoma cells. Cell Cycle. 2014;13(19):3143-9. DMR24MI RU https://pubmed.ncbi.nlm.nih.gov/25486573 DM7FN12 DI DM7FN12 DM7FN12 DN GSK2256294 DM7FN12 MI TT7WVHI DM7FN12 MN Soluble epoxide hydrolase (EPHX2) DM7FN12 MT DTT DM7FN12 MA Modulator DM7FN12 RN In vitro and in vivo characterization of a novel soluble epoxide hydrolase inhibitor. Prostaglandins Other Lipid Mediat. 2013 Jul-Aug;104-105:25-31. DM7FN12 RU https://pubmed.ncbi.nlm.nih.gov/23434473 DMOWTRL DI DMOWTRL DMOWTRL DN GSK-2315698 DMOWTRL MI TTB7VAT DMOWTRL MN Serum amyloid P-component (APCS) DMOWTRL MT DTT DMOWTRL RN Target Mediated Drug Disposition Model of CPHPC in Patients with Systemic Amyloidosis. CPT Pharmacometrics Syst Pharmacol. 2015 February; 4(2): e15. DMOWTRL RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4360666/ DMZ5A6D DI DMZ5A6D DMZ5A6D DN GSK2398852 DMZ5A6D MI TTB7VAT DMZ5A6D MN Serum amyloid P-component (APCS) DMZ5A6D MT DTT DMZ5A6D RN ClinicalTrials.gov (NCT01777243) A Study to Evaluate the Safety of GSK2398852 When Co-administered With GSK2315698 in Patients With Systemic Amyloidosis. U.S. National Institutes of Health. DMZ5A6D RU https://clinicaltrials.gov/ct2/show/NCT01777243 DMIVHDN DI DMIVHDN DMIVHDN DN GSK2618960 DMIVHDN MI TT8FRMO DMIVHDN MN Interleukin-7 (IL7) DMIVHDN MT DTT DMIVHDN MA Modulator DMIVHDN RN ClinicalTrials.gov (NCT02293161) Single Ascending Doses Study of Anti- Interleukin-7 Receptor alpha Monoclonal Antibody (GSK2618960) in Healthy Volunteers. U.S. National Institutes of Health. DMIVHDN RU https://clinicaltrials.gov/ct2/show/NCT02293161 DMCBGLW DI DMCBGLW DMCBGLW DN GSK2636771 DMCBGLW MI TTTHBCA DMCBGLW MN PI3-kinase beta (PIK3CB) DMCBGLW MT DTT DMCBGLW MA Inhibitor DMCBGLW RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7967). DMCBGLW RU http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=7967 DMQOM5V DI DMQOM5V DMQOM5V DN GSK2646264 DMQOM5V MI TTOU65C DMQOM5V MN Tyrosine-protein kinase SYK (SYK) DMQOM5V MT DTT DMQOM5V MA Inhibitor DMQOM5V RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMQOM5V RU http://phrma-docs.phrma.org/files/dmfile/MID_Skin_Diseases_2018_9_FINAL.pdf DM3KARJ DI DM3KARJ DM3KARJ DN GSK2647544 DM3KARJ MI TTDNFMT DM3KARJ MN Platelet-activating factor acetylhydrolase (PLA2G7) DM3KARJ MT DTT DM3KARJ MA Modulator DM3KARJ RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1432). DM3KARJ RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1432 DMAK89L DI DMAK89L DMAK89L DN GSK2661380 DMAK89L MI TTNBFWK DMAK89L MN Programmed cell death protein 1 (PD-1) DMAK89L MT DTT DMAK89L MA Inhibitor DMAK89L RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2760). DMAK89L RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2760 DMSGNVK DI DMSGNVK DMSGNVK DN GSK2793660 DMSGNVK MI TT4H0V2 DMSGNVK MN Dipeptidyl peptidase I (CTSC) DMSGNVK MT DTT DMSGNVK MA Modulator DMSGNVK RN ClinicalTrials.gov (NCT02058407) A Study to Evaluate the Safety, Tolerability, Pharmacokinetics (PK), Pharmacodynamics (PD) and Food Effect of Single or Repeat Doses of GSK2793660 in Healthy Subjects. U.S. National Institutes of Health. DMSGNVK RU https://clinicaltrials.gov/ct2/show/NCT02058407 DMJDVW4 DI DMJDVW4 DMJDVW4 DN GSK2816126 DMJDVW4 MI TT9MZCQ DMJDVW4 MN Enhancer of zeste homolog 2 (EZH2) DMJDVW4 MT DTT DMJDVW4 MA Modulator DMJDVW4 RN National Cancer Institute Drug Dictionary (drug id 756211). DMJDVW4 RU http://www.cancer.gov/publications/dictionaries/cancer-drug?cdrid=756211 DMU1X8K DI DMU1X8K DMU1X8K DN GSK2820151 DMU1X8K MI TTE4BSY DMU1X8K MN Bromodomain and extraterminal domain protein (BET) DMU1X8K MT DTT DMU1X8K MA Inhibitor DMU1X8K RN ClinicalTrials.gov (NCT02630251) Dose Escalation Study of GSK2820151 in Subjects With Advanced or Recurrent Solid Tumors. U.S. National Institutes of Health. DMU1X8K RU https://clinicaltrials.gov/ct2/show/NCT02630251 DMC47M9 DI DMC47M9 DMC47M9 DN GSK2831781 DMC47M9 MI TTNVXAW DMC47M9 MN Lymphocyte activation gene 3 protein (LAG3) DMC47M9 MT DTT DMC47M9 MA Inhibitor DMC47M9 RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMC47M9 RU http://phrma-docs.phrma.org/files/dmfile/MID_Skin_Diseases_2018_9_FINAL.pdf DM6KE4G DI DM6KE4G DM6KE4G DN GSK2849330 DM6KE4G MI TTDC8N2 DM6KE4G MN Erbb3 tyrosine kinase receptor (Erbb-3) DM6KE4G MT DTT DM6KE4G RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1798). DM6KE4G RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1798 DMT3V2W DI DMT3V2W DMT3V2W DN GSK2879552 DMT3V2W MI TTNR0UQ DMT3V2W MN Lysine-specific histone demethylase 1 (LSD) DMT3V2W MT DTT DMT3V2W MA Inhibitor DMT3V2W RN A DNA Hypomethylation Signature Predicts Antitumor Activity of LSD1 Inhibitors in SCLC. Cancer Cell. 2015 Jul 13;28(1):57-69. DMT3V2W RU https://pubmed.ncbi.nlm.nih.gov/26175415 DM4ZK6G DI DM4ZK6G DM4ZK6G DN GSK3050002 DM4ZK6G MI TT2XAZY DM4ZK6G MN Liver and activation-regulated chemokine (CCL20) DM4ZK6G MT DTT DM4ZK6G MA Inhibitor DM4ZK6G RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DM4ZK6G RU http://phrma-docs.phrma.org/files/dmfile/medicines-in-development-drug-list-autoimmune-diseases.pdf DMCKNJX DI DMCKNJX DMCKNJX DN GSK3052230 DMCKNJX MI TT5HU6Z DMCKNJX MN Fibroblast growth factor (FGF) DMCKNJX MT DTT DMCKNJX MA Inhibitor DMCKNJX RN National Cancer Institute Drug Dictionary (drug id 599037). DMCKNJX RU http://www.cancer.gov/publications/dictionaries/cancer-drug?cdrid=599037 DM70DYV DI DM70DYV DM70DYV DN GSK311739 DM70DYV MI TTBH0VX DM70DYV MN Histone deacetylase (HDAC) DM70DYV MT DTT DM70DYV MA Modulator DM70DYV RN Clinical pipeline report, company report or official report of Phrma.org Leading Chronic Diseases Affecting Seniors 2014. DM70DYV RU http://www.phrma.org/sites/default/files/pdf/2014-meds-in-dev-older-americans.pdf DMQZSXD DI DMQZSXD DMQZSXD DN GSK3117391 DMQZSXD MI TTBH0VX DMQZSXD MN Histone deacetylase (HDAC) DMQZSXD MT DTT DMQZSXD MA Modulator DMQZSXD RN The many roles of histone deacetylases in development and physiology: implications for disease and therapy. Nat Rev Genet. 2009 January; 10(1): 32-42. DMQZSXD RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3215088/ DM2KCIP DI DM2KCIP DM2KCIP DN GSK3179106 DM2KCIP MI TT4DXQT DM2KCIP MN Proto-oncogene c-Ret (RET) DM2KCIP MT DTT DM2KCIP MA Inhibitor DM2KCIP RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DM2KCIP RU http://phrma-docs.phrma.org/files/dmfile/medicines-in-development-drug-list-autoimmune-diseases.pdf DMJAVN7 DI DMJAVN7 DMJAVN7 DN GSK3186899 DMJAVN7 MI TTJ21A9 DMJAVN7 MN Cyclin-dependent kinase 12 (CDK12) DMJAVN7 MT DTT DMJAVN7 MA Inhibitor DMJAVN7 RN Clinical pipeline report, company report or official report of GlaxoSmithKline. DMJAVN7 RU https://www.gsk.com/en-gb/research-and-development/our-pipeline/ DMVEGND DI DMVEGND DMVEGND DN GSK3368715 DMVEGND MI TTVOJAI DMVEGND MN Protein arginine methyltransferase 1 (PRMT1) DMVEGND MT DTT DMVEGND MA Inhibitor DMVEGND RN National Cancer Institute Drug Dictionary (drug name GSK6097608). DMVEGND RU https://www.cancer.gov/publications/dictionaries/cancer-drug/def/prmt1-inhibitor-gsk3368715 DMIEAMU DI DMIEAMU DMIEAMU DN GSK-356278 DMIEAMU MI TTZ97H5 DMIEAMU MN Phosphodiesterase 4A (PDE4A) DMIEAMU MT DTT DMIEAMU MA Inhibitor DMIEAMU RN GSK356278, a potent, selective, brain-penetrant phosphodiesterase 4 inhibitor that demonstrates anxiolytic and cognition-enhancing effects without inducing side effects in preclinical species. J Pharmacol Exp Ther. 2014 Jul;350(1):153-63. DMIEAMU RU https://pubmed.ncbi.nlm.nih.gov/24784567 DMIEAMU DI DMIEAMU DMIEAMU DN GSK-356278 DMIEAMU MI TTVIAT9 DMIEAMU MN Phosphodiesterase 4B (PDE4B) DMIEAMU MT DTT DMIEAMU MA Inhibitor DMIEAMU RN GSK356278, a potent, selective, brain-penetrant phosphodiesterase 4 inhibitor that demonstrates anxiolytic and cognition-enhancing effects without inducing side effects in preclinical species. J Pharmacol Exp Ther. 2014 Jul;350(1):153-63. DMIEAMU RU https://pubmed.ncbi.nlm.nih.gov/24784567 DMIEAMU DI DMIEAMU DMIEAMU DN GSK-356278 DMIEAMU MI TTSKMI8 DMIEAMU MN Phosphodiesterase 4D (PDE4D) DMIEAMU MT DTT DMIEAMU MA Inhibitor DMIEAMU RN GSK356278, a potent, selective, brain-penetrant phosphodiesterase 4 inhibitor that demonstrates anxiolytic and cognition-enhancing effects without inducing side effects in preclinical species. J Pharmacol Exp Ther. 2014 Jul;350(1):153-63. DMIEAMU RU https://pubmed.ncbi.nlm.nih.gov/24784567 DMRYNJD DI DMRYNJD DMRYNJD DN GSK3745417 DMRYNJD MI TTT402Y DMRYNJD MN Stimulator of interferon genes protein (TMEM173) DMRYNJD MT DTT DMRYNJD MA Agonist DMRYNJD RN National Cancer Institute Drug Dictionary (drug name GSK3745417). DMRYNJD RU https://www.cancer.gov/publications/dictionaries/cancer-drug/def/sting-agonist-gsk3745417 DM1UQ4Y DI DM1UQ4Y DM1UQ4Y DN GSK3845097 DM1UQ4Y MI TTE5ITK DM1UQ4Y MN Cancer/testis antigen 1 (NY-ESO-1) DM1UQ4Y MT DTT DM1UQ4Y RN Clinical pipeline report, company report or official report of GlaxoSmithKline. DM1UQ4Y RU https://www.gsk.com/en-gb/research-and-development/our-pipeline/ DMN4I7P DI DMN4I7P DMN4I7P DN GSK3901961 DMN4I7P MI TTE5ITK DMN4I7P MN Cancer/testis antigen 1 (NY-ESO-1) DMN4I7P MT DTT DMN4I7P RN Clinical pipeline report, company report or official report of GlaxoSmithKline. DMN4I7P RU https://www.gsk.com/en-gb/research-and-development/our-pipeline/ DMI3FU6 DI DMI3FU6 DMI3FU6 DN GSK4074386 DMI3FU6 MI TTNVXAW DMI3FU6 MN Lymphocyte activation gene 3 protein (LAG3) DMI3FU6 MT DTT DMI3FU6 MA Inhibitor DMI3FU6 RN Clinical pipeline report, company report or official report of GlaxoSmithKline. DMI3FU6 RU https://www.gsk.com/en-gb/research-and-development/our-pipeline/ DM0P729 DI DM0P729 DM0P729 DN GSK461364 DM0P729 MI TTIYVQP DM0P729 MN Polo-like kinase 1 (PLK1) DM0P729 MT DTT DM0P729 MA Inhibitor DM0P729 RN Polo-like kinase (PLK) inhibitors in preclinical and early clinical development in oncology. Oncologist. 2009 Jun;14(6):559-70. DM0P729 RU https://pubmed.ncbi.nlm.nih.gov/19474163 DMPAWBN DI DMPAWBN DMPAWBN DN GSK525762 DMPAWBN MI TTE4BSY DMPAWBN MN Bromodomain and extraterminal domain protein (BET) DMPAWBN MT DTT DMPAWBN MA Inhibitor DMPAWBN RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMPAWBN RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DMPAWBN DI DMPAWBN DMPAWBN DN GSK525762 DMPAWBN MI TTRA6BO DMPAWBN MN Bromodomain-containing protein 4 (BRD4) DMPAWBN MT DTT DMPAWBN MA Modulator DMPAWBN RN Targeting bromodomains: epigenetic readers of lysine acetylation.Nat Rev Drug Discov.2014 May;13(5):337-56. DMPAWBN RU https://www.ncbi.nlm.nih.gov/pubmed/24751816 DM5E9LX DI DM5E9LX DM5E9LX DN GSK586529 DM5E9LX MI TT7EFHR DM5E9LX MN Corticotropin-releasing factor receptor 1 (CRHR1) DM5E9LX MT DTT DM5E9LX MA Antagonist DM5E9LX RN Clinical pipeline report, company report or official report of GlaxoSmithKline (2009). DM5E9LX RU http://www.gsk.com/investors/product_pipeline/docs/gsk-pipeline-feb09.pdf DMWI0AL DI DMWI0AL DMWI0AL DN GSK6097608 DMWI0AL MI TT83C4X DMWI0AL MN T-cell surface protein tactile (CD96) DMWI0AL MT DTT DMWI0AL MA Antagonist DMWI0AL RN National Cancer Institute Drug Dictionary (drug name GSK6097608). DMWI0AL RU https://www.cancer.gov/publications/dictionaries/cancer-drug/def/anti-cd96-monoclonal-antibody-gsk6097608 DMJPXZ4 DI DMJPXZ4 DMJPXZ4 DN GSK618334 DMJPXZ4 MI DE3GT9C DMJPXZ4 MN Cytochrome P450 4F2 (CYP4F2) DMJPXZ4 MT DME DMJPXZ4 MA Metabolism DMJPXZ4 RN Product information - Gilenya. DMJPXZ4 RU http://www.medsafe.govt.nz/profs/datasheet/g/gilenyacap.pdf DMJPXZ4 DI DMJPXZ4 DMJPXZ4 DN GSK618334 DMJPXZ4 MI TT4C8EA DMJPXZ4 MN Dopamine D3 receptor (D3R) DMJPXZ4 MT DTT DMJPXZ4 MA Antagonist DMJPXZ4 RN Clinical pipeline report, company report or official report of GlaxoSmithKline (2009). DMJPXZ4 RU http://www.gsk.com/investors/product_pipeline/docs/gsk-pipeline-feb09.pdf DMJPXZ4 DI DMJPXZ4 DMJPXZ4 DN GSK618334 DMJPXZ4 MI TTOHFIY DMJPXZ4 MN Sphingosine kinase 1 (SPHK1) DMJPXZ4 MT DTT DMJPXZ4 MA Inhibitor DMJPXZ4 RN Sphingosine kinase 1 is a potential therapeutic target for nasopharyngeal carcinoma.Oncotarget. 2016 Dec 6;7(49):80586-80598. DMJPXZ4 RU https://pubmed.ncbi.nlm.nih.gov/27811359 DM7CIN4 DI DM7CIN4 DM7CIN4 DN GSK-625433 DM7CIN4 MI TTMVBWH DM7CIN4 MN Hepatitis C virus RNA-directed RNA polymerase (HCV NS5B) DM7CIN4 MT DTT DM7CIN4 MA Inhibitor DM7CIN4 RN Preclinical Characterization of PF-00868554, a Potent Nonnucleoside Inhibitor of the Hepatitis C Virus RNA-Dependent RNA Polymerase . Antimicrob Agents Chemother. 2009 June; 53(6): 2544-2552. DM7CIN4 RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2687230/ DMRBVHE DI DMRBVHE DMRBVHE DN GSK690693 DMRBVHE MI TTAZ05C DMRBVHE MN RAC-gamma serine/threonine-protein kinase (AKT3) DMRBVHE MT DTT DMRBVHE MA Modulator DMRBVHE RN Characterization of an Akt kinase inhibitor with potent pharmacodynamic and antitumor activity.Cancer Res.2008 Apr 1;68(7):2366-74. DMRBVHE RU https://www.ncbi.nlm.nih.gov/pubmed/18381444 DM4LR0Y DI DM4LR0Y DM4LR0Y DN GSK-958108 DM4LR0Y MI TTSQIFT DM4LR0Y MN 5-HT 1A receptor (HTR1A) DM4LR0Y MT DTT DM4LR0Y MA Antagonist DM4LR0Y RN Clinical pipeline report, company report or official report of GlaxoSmithKline. DM4LR0Y RU https://gsk.sylogent.com/files/24664.pdf DMX2J57 DI DMX2J57 DMX2J57 DN GT103 DMX2J57 MI TTUW6OP DMX2J57 MN Complement factor H (CFH) DMX2J57 MT DTT DMX2J57 MA Inhibitor DMX2J57 RN Clinical pipeline report, company report or official report of Grid Therapeutics. DMX2J57 RU https://gridtherapeutics.com/research-development/gt103/ DM20HS7 DI DM20HS7 DM20HS7 DN GTP-004 DM20HS7 MI TT1RS9F DM20HS7 MN Acetylcholinesterase (AChE) DM20HS7 MT DTT DM20HS7 MA Inhibitor DM20HS7 RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DM20HS7 RU http://phrma-docs.phrma.org/files/dmfile/MID_Neurological-Disorders-Drug-List_2018.pdf DM4T5LH DI DM4T5LH DM4T5LH DN Guanosine DM4T5LH MI TT1U2YM DM4T5LH MN Cytomegalovirus DNA polymerase (CMV UL54) DM4T5LH MT DTT DM4T5LH MA Inhibitor DM4T5LH RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DM4T5LH RU https://pubmed.ncbi.nlm.nih.gov/17139284 DM4T5LH DI DM4T5LH DM4T5LH DN Guanosine DM4T5LH MI TTIU7X1 DM4T5LH MN Herpes simplex virus DNA polymerase UL30 (HSV UL30) DM4T5LH MT DTT DM4T5LH MA Inhibitor DM4T5LH RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DM4T5LH RU https://pubmed.ncbi.nlm.nih.gov/17139284 DM4T5LH DI DM4T5LH DM4T5LH DN Guanosine DM4T5LH MI TTMCF1Y DM4T5LH MN Purine nucleoside phosphorylase (PNP) DM4T5LH MT DTT DM4T5LH MA Inhibitor DM4T5LH RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DM4T5LH RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMM1RB6 DI DMM1RB6 DMM1RB6 DN GW-328267 DMM1RB6 MI TTM2AOE DMM1RB6 MN Adenosine A2a receptor (ADORA2A) DMM1RB6 MT DTT DMM1RB6 MA Modulator DMM1RB6 RN ADENOSINE RECEPTORS AS TARGETS FOR THERAPEUTIC INTERVENTION IN ASTHMA AND CHRONIC OBSTRUCTIVE PULMONARY DISEASE DMM1RB6 RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2778268 DMOE5SZ DI DMOE5SZ DMOE5SZ DN GW-409544 DMOE5SZ MI TTJ584C DMOE5SZ MN Peroxisome proliferator-activated receptor alpha (PPARA) DMOE5SZ MT DTT DMOE5SZ MA Modulator DMOE5SZ RN Design novel dual agonists for treating type-2 diabetes by targeting peroxisome proliferator-activated receptors with core hopping approach. PLoS One. 2012;7(6):e38546. DMOE5SZ RU https://pubmed.ncbi.nlm.nih.gov/22685582 DMOE5SZ DI DMOE5SZ DMOE5SZ DN GW-409544 DMOE5SZ MI TTZMAO3 DMOE5SZ MN Peroxisome proliferator-activated receptor gamma (PPAR-gamma) DMOE5SZ MT DTT DMOE5SZ MA Modulator DMOE5SZ RN Design novel dual agonists for treating type-2 diabetes by targeting peroxisome proliferator-activated receptors with core hopping approach. PLoS One. 2012;7(6):e38546. DMOE5SZ RU https://pubmed.ncbi.nlm.nih.gov/22685582 DMBDW93 DI DMBDW93 DMBDW93 DN GW-695634 DMBDW93 MI TT84ETX DMBDW93 MN Human immunodeficiency virus Reverse transcriptase (HIV RT) DMBDW93 MT DTT DMBDW93 MA Inhibitor DMBDW93 RN Next-generation HIV-1 non-nucleoside reverse transcriptase inhibitors. Curr Opin Investig Drugs. 2006 Feb;7(2):128-35. DMBDW93 RU https://pubmed.ncbi.nlm.nih.gov/16499282 DMQ46DN DI DMQ46DN DMQ46DN DN GW-796406 DMQ46DN MI TTL69WB DMQ46DN MN Angiotensin-converting enzyme (ACE) DMQ46DN MT DTT DMQ46DN MA Modulator DMQ46DN RN Mechanism of vasopeptidase inhibitor-induced plasma extravasation: comparison of omapatrilat and the novel neutral endopeptidase 24.11/angiotensin-converting enzyme inhibitor GW796406. J Pharmacol Exp Ther. 2005 Dec;315(3):1306-13. DMQ46DN RU https://pubmed.ncbi.nlm.nih.gov/16144980 DMQ46DN DI DMQ46DN DMQ46DN DN GW-796406 DMQ46DN MI TT5TKPM DMQ46DN MN Neutral endopeptidase (MME) DMQ46DN MT DTT DMQ46DN MA Modulator DMQ46DN RN Mechanism of vasopeptidase inhibitor-induced plasma extravasation: comparison of omapatrilat and the novel neutral endopeptidase 24.11/angiotensin-converting enzyme inhibitor GW796406. J Pharmacol Exp Ther. 2005 Dec;315(3):1306-13. DMQ46DN RU https://pubmed.ncbi.nlm.nih.gov/16144980 DMGO6M1 DI DMGO6M1 DMGO6M1 DN GZ402666 DMGO6M1 MI TTLPC70 DMGO6M1 MN Lysosomal alpha-glucosidase (GAA) DMGO6M1 MT DTT DMGO6M1 MA Modulator DMGO6M1 RN ClinicalTrials.gov (NCT01898364) Safety and Efficacy Evaluation of Repeat neoGAA Dosing in Late Onset Pompe Disease Patients.. U.S. National Institutes of Health. DMGO6M1 RU https://clinicaltrials.gov/ct2/show/NCT01898364 DME6VX4 DI DME6VX4 DME6VX4 DN GZ402668 DME6VX4 MI TTQT5S9 DME6VX4 MN Cambridge pathology 1 antigen (CD52) DME6VX4 MT DTT DME6VX4 RN Characterization of a Next Generation Anti-CD52 Antibody. Neurology. April 6, 2015 vol. 84 no. 14. DME6VX4 RU http://www.neurology.org/content/84/14_Supplement/S20.006 DMTWNLY DI DMTWNLY DMTWNLY DN GZ402674 DMTWNLY MI TTGTQHC DMTWNLY MN DNA topoisomerase I (TOP1) DMTWNLY MT DTT DMTWNLY MA Modulator DMTWNLY RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2636). DMTWNLY RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2636 DMRCHOU DI DMRCHOU DMRCHOU DN H-103 DMRCHOU MI TTHYBIX DMRCHOU MN Heat shock protein 70 (HSP70) DMRCHOU MT DTT DMRCHOU MA Modulator DMRCHOU RN A phase I trial of intratumoral administration of recombinant oncolytic adenovirus overexpressing HSP70 in advanced solid tumor patients. Gene Ther. 2009 Mar;16(3):376-82. DMRCHOU RU https://pubmed.ncbi.nlm.nih.gov/19092859 DMAYTRK DI DMAYTRK DMAYTRK DN H3B-6527 DMAYTRK MI DE4LYSA DMAYTRK MN Cytochrome P450 3A4 (CYP3A4) DMAYTRK MT DME DMAYTRK MA Metabolism DMAYTRK RN Correlation of the in vitro biotransformation of H3B-6527 in dog and human hepatocytes with the in vivo metabolic profile of 14C-H3B-6527 in a dog mass balance study. Xenobiotica. 2020 Apr;50(4):458-467. DMAYTRK RU https://www.ncbi.nlm.nih.gov/pubmed/?term=31305210 DMAYTRK DI DMAYTRK DMAYTRK DN H3B-6527 DMAYTRK MI DEIBDNY DMAYTRK MN Cytochrome P450 3A5 (CYP3A5) DMAYTRK MT DME DMAYTRK MA Metabolism DMAYTRK RN Correlation of the in vitro biotransformation of H3B-6527 in dog and human hepatocytes with the in vivo metabolic profile of 14C-H3B-6527 in a dog mass balance study. Xenobiotica. 2020 Apr;50(4):458-467. DMAYTRK RU https://www.ncbi.nlm.nih.gov/pubmed/?term=31305210 DMAYTRK DI DMAYTRK DMAYTRK DN H3B-6527 DMAYTRK MI TT1KX2S DMAYTRK MN FGFR4 messenger RNA (FGFR4 mRNA) DMAYTRK MT DTT DMAYTRK MA Inhibitor DMAYTRK RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMAYTRK RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DMMVXGR DI DMMVXGR DMMVXGR DN H3B-8800 DMMVXGR MI TTXR78S DMMVXGR MN SF3b complex (SF3b) DMMVXGR MT DTT DMMVXGR MA Modulator DMMVXGR RN Clinical pipeline report, company report or official report of H3 Biomedicine. DMMVXGR RU https://www.h3biomedicine.com/science/ DMHI8RS DI DMHI8RS DMHI8RS DN HCBE-11 DMHI8RS MI TTFO0PM DMHI8RS MN Lymphotoxin beta receptor (LTBR) DMHI8RS MT DTT DMHI8RS RN Lymphotoxin beta receptor activation on macrophages induces cross-tolerance to TLR4 and TLR9 ligands. J Immunol. 2012 Apr 1;188(7):3426-33. DMHI8RS RU https://pubmed.ncbi.nlm.nih.gov/22357629 DMVRTCW DI DMVRTCW DMVRTCW DN HDM201 DMVRTCW MI TT7SBF5 DMVRTCW MN Cellular tumor antigen p53 (TP53) DMVRTCW MT DTT DMVRTCW MA Inhibitor DMVRTCW RN National Cancer Institute Drug Dictionary (drug id 761551). DMVRTCW RU http://www.cancer.gov/publications/dictionaries/cancer-drug?cdrid=761551 DMVRTCW DI DMVRTCW DMVRTCW DN HDM201 DMVRTCW MI TT08GJW DMVRTCW MN Ubiquitin-protein ligase E3 Mdm2 (MDM2) DMVRTCW MT DTT DMVRTCW MA Inhibitor DMVRTCW RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMVRTCW RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DMM7VOB DI DMM7VOB DMM7VOB DN Hepapoietin DMM7VOB MI TTNDSF4 DMM7VOB MN Proto-oncogene c-Met (MET) DMM7VOB MT DTT DMM7VOB MA Inhibitor DMM7VOB RN Pharmacokinetics and biochemical effects of hepapoietin in patients with chronic liver disease. Alimentary Pharmacology & Therapeutics Volume 16, Issue 2, pages 235-242, February 2002. DMM7VOB RU http://onlinelibrary.wiley.com/doi/10.1046/j.1365-2036.2002.01110.x/full DMBFYSR DI DMBFYSR DMBFYSR DN Hepcidin mab DMBFYSR MI TTPCG5T DMBFYSR MN Hepcidin (HAMP) DMBFYSR MT DTT DMBFYSR RN The pathophysiology and pharmacology of hepcidin. Trends Pharmacol Sci. 2014 March; 35(3): 155-161. DMBFYSR RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3978192/ DMXETUQ DI DMXETUQ DMXETUQ DN HER-2/HER-1 vaccine DMXETUQ MI TTGKNB4 DMXETUQ MN Epidermal growth factor receptor (EGFR) DMXETUQ MT DTT DMXETUQ RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1797). DMXETUQ RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1797 DMZXDBN DI DMZXDBN DMZXDBN DN HER2-CAR T Cells DMZXDBN MI TT6EO5L DMZXDBN MN Erbb2 tyrosine kinase receptor (HER2) DMZXDBN MT DTT DMZXDBN MA CAR-T-Cell-Therapy DMZXDBN RN ClinicalTrials.gov (NCT03696030) HER2-CAR T Cells in Treating Participants With Brain or Leptomeningeal Metastases DMZXDBN RU https://clinicaltrials.gov/ct2/show/NCT03696030 DMJ52F9 DI DMJ52F9 DMJ52F9 DN HER2p63-71 peptide vaccine DMJ52F9 MI TT6EO5L DMJ52F9 MN Erbb2 tyrosine kinase receptor (HER2) DMJ52F9 MT DTT DMJ52F9 RN Development of a cancer vaccine: peptides, proteins, and DNA. Cancer Chemother Pharmacol. 2000;46 Suppl:S77-82. DMJ52F9 RU https://pubmed.ncbi.nlm.nih.gov/10950153 DMJKBWO DI DMJKBWO DMJKBWO DN HER2-specific CAR T cell DMJKBWO MI TT6EO5L DMJKBWO MN Erbb2 tyrosine kinase receptor (HER2) DMJKBWO MT DTT DMJKBWO MA CAR-T-Cell-Therapy DMJKBWO RN ClinicalTrials.gov (NCT03500991) HER2-specific CAR T Cell Locoregional Immunotherapy for HER2-positive Recurrent/Refractory Pediatric CNS Tumors DMJKBWO RU https://clinicaltrials.gov/ct2/show/NCT03500991 DM7UJ6E DI DM7UJ6E DM7UJ6E DN HER2-specific T cells DM7UJ6E MI TT6EO5L DM7UJ6E MN Erbb2 tyrosine kinase receptor (HER2) DM7UJ6E MT DTT DM7UJ6E MA CAR-T-Cell-Therapy DM7UJ6E RN ClinicalTrials.gov (NCT02442297) T Cells Expressing HER2-specific Chimeric Antigen Receptors(CAR) for Patients With Glioblastoma DM7UJ6E RU https://clinicaltrials.gov/ct2/show/NCT02442297 DMDZQ23 DI DMDZQ23 DMDZQ23 DN HF-0299 DMDZQ23 MI TTHRID2 DMDZQ23 MN Insulin-like growth factor I receptor (IGF1R) DMDZQ23 MT DTT DMDZQ23 MA Modulator DMDZQ23 RN A primary adrenal steroid, 11beta-hydroxyandrostenedione, has an osteotropic effect and little androgenic activity. J Steroid Biochem Mol Biol. 2000 Nov 15;74(4):203-11. DMDZQ23 RU https://pubmed.ncbi.nlm.nih.gov/11162926 DMS9WXG DI DMS9WXG DMS9WXG DN HGS-1029 DMS9WXG MI TTR7B60 DMS9WXG MN X-linked inhibitor of apoptosis protein (XIAP) DMS9WXG MT DTT DMS9WXG MA Antagonist DMS9WXG RN Clinical pipeline report, company report or official report of Aegera Therapeutics Inc. DMS9WXG RU http://www.aegera.com/aeg40826.php DMQIE58 DI DMQIE58 DMQIE58 DN HH2853 DMQIE58 MI TTNJA0C DMQIE58 MN Enhancer of zeste homolog 1 (EZH1) DMQIE58 MT DTT DMQIE58 MA Inhibitor DMQIE58 RN Clinical pipeline report, company report or official report of HaiHe Biopharma. DMQIE58 RU https://www.haihepharma.com/en/news/details/215 DMQIE58 DI DMQIE58 DMQIE58 DN HH2853 DMQIE58 MI TT9MZCQ DMQIE58 MN Enhancer of zeste homolog 2 (EZH2) DMQIE58 MT DTT DMQIE58 MA Inhibitor DMQIE58 RN Clinical pipeline report, company report or official report of HaiHe Biopharma. DMQIE58 RU https://www.haihepharma.com/en/news/details/215 DMRQ4L6 DI DMRQ4L6 DMRQ4L6 DN HHCYH33 DMRQ4L6 MI TTEUNMR DMRQ4L6 MN PI3-kinase alpha (PIK3CA) DMRQ4L6 MT DTT DMRQ4L6 MA Inhibitor DMRQ4L6 RN Adaptive resistance to PI3Kalpha-selective inhibitor CYH33 is mediated by genomic and transcriptomic alterations in ESCC cells. Cell Death Dis. 2021 Jan 14;12(1):85. DMRQ4L6 RU https://pubmed.ncbi.nlm.nih.gov/33446653 DM45MR0 DI DM45MR0 DM45MR0 DN HIP-2B DM45MR0 MI TTL4H8N DM45MR0 MN Regenerating human pro-islet peptide (REG3A) DM45MR0 MT DTT DM45MR0 MA Modulator DM45MR0 RN Hepatocarcinoma-intestine-pancreas/pancreatic associated protein (HIP/PAP) is expressed and secreted by proliferating ductules as well as by hepatocarcinoma and cholangiocarcinoma cells. Am J Pathol.1999 Nov;155(5):1525-33. DM45MR0 RU https://pubmed.ncbi.nlm.nih.gov/10550309 DMT3HKZ DI DMT3HKZ DMT3HKZ DN HL-018 DMT3HKZ MI TT0FYAN DMT3HKZ MN Free fatty acid receptor 2 (FFAR2) DMT3HKZ MT DTT DMT3HKZ MA Inhibitor DMT3HKZ RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 226). DMT3HKZ RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=226 DME4D7H DI DME4D7H DME4D7H DN HM71224 DME4D7H MI TTGM6VW DME4D7H MN Tyrosine-protein kinase BTK (ATK) DME4D7H MT DTT DME4D7H MA Inhibitor DME4D7H RN HM71224, a selective Bruton's tyrosine kinase inhibitor, attenuates the development of murine lupus. Arthritis Res Ther. 2017 Sep 26;19(1):211. DME4D7H RU https://pubmed.ncbi.nlm.nih.gov/28950886 DMXZ1A8 DI DMXZ1A8 DMXZ1A8 DN HMPL-523 DMXZ1A8 MI TTOU65C DMXZ1A8 MN Tyrosine-protein kinase SYK (SYK) DMXZ1A8 MT DTT DMXZ1A8 MA Inhibitor DMXZ1A8 RN Clinical pipeline report, company report or official report of Hutchison MediPharma. DMXZ1A8 RU https://www.hutch-med.com/pipeline-and-products/our-pipeline/ DMEGN5I DI DMEGN5I DMEGN5I DN HMPL-689 DMEGN5I MI TTGBPJE DMEGN5I MN PI3-kinase delta (PIK3CD) DMEGN5I MT DTT DMEGN5I MA Inhibitor DMEGN5I RN Clinical pipeline report, company report or official report of Hutchison MediPharma. DMEGN5I RU https://www.hutch-med.com/pipeline-and-products/our-pipeline/ DM695QT DI DM695QT DM695QT DN HMR-1031 DM695QT MI TT6S84X DM695QT MN Integrin alpha-4/beta-1 (ITGA4/B1) DM695QT MT DTT DM695QT MA Modulator DM695QT RN Pharmacoscintigraphic comparison of HMR 1031, a VLA-4 antagonist, in healthy volunteers following delivery via a nebulizer and a dry powder inhaler. Am J Ther. 2004 Mar-Apr;11(2):103-13. DM695QT RU https://pubmed.ncbi.nlm.nih.gov/14999362 DMRYM03 DI DMRYM03 DMRYM03 DN HMS5552 DMRYM03 MI TTDLNGZ DMRYM03 MN Glucokinase (GCK) DMRYM03 MT DTT DMRYM03 MA Activator DMRYM03 RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMRYM03 RU http://phrma-docs.phrma.org/files/dmfile/mid-diabetes-drug-list.pdf DMI0KQW DI DMI0KQW DMI0KQW DN HPN217 DMI0KQW MI TTZ3P4W DMI0KQW MN B-cell maturation protein (TNFRSF17) DMI0KQW MT DTT DMI0KQW RN Clinical pipeline report, company report or official report of AbbVie. DMI0KQW RU https://www.abbvie.com/our-science/pipeline/hpn-217.html DMLZDVR DI DMLZDVR DMLZDVR DN HPN424 DMLZDVR MI TT9G4N0 DMLZDVR MN Glutamate carboxypeptidase II (GCPII) DMLZDVR MT DTT DMLZDVR RN Clinical pipeline report, company report or official report of Harpoon Therapeutics. DMLZDVR RU https://www.harpoontx.com/pipeline/ DMUEZ7V DI DMUEZ7V DMUEZ7V DN HPP404 DMUEZ7V MI TT9JNIC DMUEZ7V MN Histamine H3 receptor (H3R) DMUEZ7V MT DTT DMUEZ7V MA Antagonist DMUEZ7V RN Clinical pipeline report, company report or official report of TransTech Pharma (2011). DMUEZ7V RU http://www.ttpharma.com/ DM5VSZR DI DM5VSZR DM5VSZR DN HPP-607 DM5VSZR MI TTPS3C0 DM5VSZR MN Aurora kinase A (AURKA) DM5VSZR MT DTT DM5VSZR MA Inhibitor DM5VSZR RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1936). DM5VSZR RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1936 DM5VSZR DI DM5VSZR DM5VSZR DN HPP-607 DM5VSZR MI TT5LS6T DM5VSZR MN Aurora kinase B (AURKB) DM5VSZR MT DTT DM5VSZR MA Inhibitor DM5VSZR RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1936). DM5VSZR RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1936 DM5VSZR DI DM5VSZR DM5VSZR DN HPP-607 DM5VSZR MI TTLYXIT DM5VSZR MN Aurora kinase C (AURKC) DM5VSZR MT DTT DM5VSZR MA Inhibitor DM5VSZR RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1936). DM5VSZR RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1936 DMSLDHG DI DMSLDHG DMSLDHG DN HPP-854 DMSLDHG MI TT8JRS7 DMSLDHG MN Beta-secretase (BACE) DMSLDHG MT DTT DMSLDHG MA Modulator DMSLDHG RN BACE1 inhibitor drugs in clinical trials for Alzheimer's disease. Alzheimers Res Ther. 2014 Dec 24;6(9):89. DMSLDHG RU https://pubmed.ncbi.nlm.nih.gov/25621019 DMZXG7Q DI DMZXG7Q DMZXG7Q DN HPP971 DMZXG7Q MI TTA6ZN2 DMZXG7Q MN Nuclear factor erythroid 2-related factor 2 (Nrf2) DMZXG7Q MT DTT DMZXG7Q MA Activator DMZXG7Q RN Clinical pipeline report, company report or official report of vTv Therapeutics. DMZXG7Q RU https://vtvtherapeutics.com/pipeline/nrf2-bach1-program/ DMJG4WR DI DMJG4WR DMJG4WR DN HSDB-674 DMJG4WR MI DEDPI65 DMJG4WR MN Oxygen-insensitive NADPH nitroreductase A (nfsA) DMJG4WR MT DME DMJG4WR MA Metabolism DMJG4WR RN Absorption of (-)-nicotine-l-N-oxide in man and its reduction in the gastrointestinal tract. J Pharm Pharmacol. 1970 Sep;22(9):722-3. DMJG4WR RU https://pubmed.ncbi.nlm.nih.gov/4394772 DML6HP3 DI DML6HP3 DML6HP3 DN HSP-990 DML6HP3 MI DE5IED8 DML6HP3 MN Cytochrome P450 2C9 (CYP2C9) DML6HP3 MT DME DML6HP3 MA Metabolism DML6HP3 RN A first-in-human phase I, dose-escalation, multicentre study of HSP990 administered orally in adult patients with advanced solid malignancies. Br J Cancer. 2015 Feb 17;112(4):650-9. DML6HP3 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=25625276 DMI4TEC DI DMI4TEC DMI4TEC DN HTI-1090 DMI4TEC MI TTZJYKH DMI4TEC MN Indoleamine 2,3-dioxygenase 1 (IDO1) DMI4TEC MT DTT DMI4TEC MA Inhibitor DMI4TEC RN Discovery of cyanopyridine scaffold as novel indoleamine-2,3-dioxygenase 1 (IDO1) inhibitors through virtual screening and preliminary hit optimisation. J Enzyme Inhib Med Chem. 2019 Dec;34(1):250-263. DMI4TEC RU https://pubmed.ncbi.nlm.nih.gov/30734612 DMI4TEC DI DMI4TEC DMI4TEC DN HTI-1090 DMI4TEC MI TTXNCBV DMI4TEC MN Tryptophan 2,3-dioxygenase (TDO) DMI4TEC MT DTT DMI4TEC MA Inhibitor DMI4TEC RN Discovery of cyanopyridine scaffold as novel indoleamine-2,3-dioxygenase 1 (IDO1) inhibitors through virtual screening and preliminary hit optimisation. J Enzyme Inhib Med Chem. 2019 Dec;34(1):250-263. DMI4TEC RU https://pubmed.ncbi.nlm.nih.gov/30734612 DMB3LQU DI DMB3LQU DMB3LQU DN HuA33 DMB3LQU MI TT96HUR DMB3LQU MN Cell surface A33 antigen (GPA33) DMB3LQU MT DTT DMB3LQU RN (124)I-huA33 antibody PET of colorectal cancer. J Nucl Med. 2011 Aug;52(8):1173-80. DMB3LQU RU https://pubmed.ncbi.nlm.nih.gov/21764796 DM9VB4I DI DM9VB4I DM9VB4I DN Hu-CART meso cells DM9VB4I MI TT4RXME DM9VB4I MN Mesothelin (MSLN) DM9VB4I MT DTT DM9VB4I MA CAR-T-Cell-Therapy DM9VB4I RN ClinicalTrials.gov (NCT03054298) CAR T Cells in Mesothelin Expressing Cancers DM9VB4I RU https://clinicaltrials.gov/ct2/show/NCT03054298 DMNAR29 DI DMNAR29 DMNAR29 DN HuCART19 DMNAR29 MI TTW640A DMNAR29 MN B-lymphocyte surface antigen B4 (CD19) DMNAR29 MT DTT DMNAR29 MA CAR-T-Cell-Therapy DMNAR29 RN ClinicalTrials.gov (NCT02374333) Pilot Study of Redirected Autologous T Cells Engineered to Contain Humanized Anti-CD19 in Patients With Relapsed or Refractory CD19+ Leukemia and Lymphoma Previously Treated With Cell Therapy DMNAR29 RU https://clinicaltrials.gov/ct2/show/NCT02374333 DM4F8AU DI DM4F8AU DM4F8AU DN HuCART-meso cells DM4F8AU MI TT4RXME DM4F8AU MN Mesothelin (MSLN) DM4F8AU MT DTT DM4F8AU MA CAR-T-Cell-Therapy DM4F8AU RN ClinicalTrials.gov (NCT03323944) CAR T Cell Immunotherapy for Pancreatic Cancer DM4F8AU RU https://clinicaltrials.gov/ct2/show/NCT03323944 DMDZBTY DI DMDZBTY DMDZBTY DN HuM195/rGel DMDZBTY MI TTJVYO3 DMDZBTY MN Myeloid cell surface antigen CD33 (CD33) DMDZBTY MT DTT DMDZBTY RN Phase 1 study of an anti-CD33 immunotoxin, humanized monoclonal antibody M195 conjugated to recombinant gelonin (HUM-195/rGEL), in patients with advanced myeloid malignancies. Haematologica. 2013 Feb;98(2):217-21. DMDZBTY RU https://pubmed.ncbi.nlm.nih.gov/22875630 DM0W275 DI DM0W275 DM0W275 DN Human CD19 targeted T Cells DM0W275 MI TTW640A DM0W275 MN B-lymphocyte surface antigen B4 (CD19) DM0W275 MT DTT DM0W275 MA CAR-T-Cell-Therapy DM0W275 RN ClinicalTrials.gov (NCT03720457) Human CD19 Targeted T Cells Injection(CD19 CAR-T) Therapy for Relapsed and Refractory CD19-positive Lymphoma. DM0W275 RU https://clinicaltrials.gov/ct2/show/NCT03720457 DMVGBA1 DI DMVGBA1 DMVGBA1 DN HuMNC2-CAR44 T cells DMVGBA1 MI TTBHFYQ DMVGBA1 MN Mucin-1 (MUC1) DMVGBA1 MT DTT DMVGBA1 RN Clinical pipeline report, company report or official report of Minerva Biotechnologies. DMVGBA1 RU https://www.minervabio.com/minervabio.com/pipeline/ DMFRM15 DI DMFRM15 DMFRM15 DN HX-100 DMFRM15 MI TTELV3W DMFRM15 MN Transformation-sensitive protein p120 (TRPA1) DMFRM15 MT DTT DMFRM15 MA Inhibitor DMFRM15 RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMFRM15 RU http://phrma-docs.phrma.org/files/dmfile/MID_Neurological-Disorders-Drug-List_2018.pdf DMRE6UT DI DMRE6UT DMRE6UT DN IBC-VS01 DMRE6UT MI TTZOPHG DMRE6UT MN Insulin (INS) DMRE6UT MT DTT DMRE6UT MA Modulator DMRE6UT RN Prevention of Type 1 Diabetes Mellitus using a Novel Vaccine. Ther Adv Endocrinol Metab. 2011 February; 2(1): 9-16. DMRE6UT RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3474625/ DMXUJ1P DI DMXUJ1P DMXUJ1P DN IBI188 DMXUJ1P MI TT28S46 DMXUJ1P MN Leukocyte surface antigen CD47 (CD47) DMXUJ1P MT DTT DMXUJ1P MA Blocker DMXUJ1P RN Clinical pipeline report, company report or official report of Innovent Biologics. DMXUJ1P RU https://www.innoventbio.com/ScienceAndProducts/Pipeline/ProductRAndD DMYBHIR DI DMYBHIR DMYBHIR DN IBI-20089 DMYBHIR MI TTYRL6O DMYBHIR MN Glucocorticoid receptor (NR3C1) DMYBHIR MT DTT DMYBHIR MA Agonist DMYBHIR RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMYBHIR RU http://phrma-docs.phrma.org/files/dmfile/mid-diabetes-drug-list.pdf DMB83V4 DI DMB83V4 DMB83V4 DN IBI318 DMB83V4 MI TT8ZLTI DMB83V4 MN Programmed cell death 1 ligand 1 (PD-L1) DMB83V4 MT DTT DMB83V4 MA Inhibitor DMB83V4 RN Clinical pipeline report, company report or official report of Innovent. DMB83V4 RU http://innoventbio.com/#/news/208 DMB83V4 DI DMB83V4 DMB83V4 DN IBI318 DMB83V4 MI TTNBFWK DMB83V4 MN Programmed cell death protein 1 (PD-1) DMB83V4 MT DTT DMB83V4 MA Inhibitor DMB83V4 RN Clinical pipeline report, company report or official report of Innovent. DMB83V4 RU http://innoventbio.com/#/news/208 DMHS29U DI DMHS29U DMHS29U DN Iboctadekin DMHS29U MI TTRICUF DMHS29U MN Interleukin-18 (IL18) DMHS29U MT DTT DMHS29U MA Modulator DMHS29U RN Chemoimmunotherapy using pegylated liposomal Doxorubicin and interleukin-18 in recurrent ovarian cancer: a phase I dose-escalation study. Cancer Immunol Res. 2013 Sep;1(3):168-78. DMHS29U RU https://pubmed.ncbi.nlm.nih.gov/24777679 DMW1ZAM DI DMW1ZAM DMW1ZAM DN Iboctadekin + Doxil DMW1ZAM MI TT0IHXV DMW1ZAM MN DNA topoisomerase II (TOP2) DMW1ZAM MT DTT DMW1ZAM MA Inhibitor DMW1ZAM RN Clinical pipeline report, company report or official report of GlaxoSmithKline (2009). DMW1ZAM RU http://www.gsk.com/investors/product_pipeline/docs/gsk-pipeline-feb09.pdf DMW1ZAM DI DMW1ZAM DMW1ZAM DN Iboctadekin + Doxil DMW1ZAM MI TTRICUF DMW1ZAM MN Interleukin-18 (IL18) DMW1ZAM MT DTT DMW1ZAM MA Modulator DMW1ZAM RN Clinical pipeline report, company report or official report of GlaxoSmithKline (2009). DMW1ZAM RU http://www.gsk.com/investors/product_pipeline/docs/gsk-pipeline-feb09.pdf DMZCBMS DI DMZCBMS DMZCBMS DN Iboctadekin + Rituximab DMZCBMS MI TTRICUF DMZCBMS MN Interleukin-18 (IL18) DMZCBMS MT DTT DMZCBMS MA Modulator DMZCBMS RN Clinical pipeline report, company report or official report of GlaxoSmithKline (2009). DMZCBMS RU http://www.gsk.com/investors/product_pipeline/docs/gsk-pipeline-feb09.pdf DMZCBMS DI DMZCBMS DMZCBMS DN Iboctadekin + Rituximab DMZCBMS MI TTUE541 DMZCBMS MN Leukocyte surface antigen Leu-16 (CD20) DMZCBMS MT DTT DMZCBMS RN Clinical pipeline report, company report or official report of GlaxoSmithKline (2009). DMZCBMS RU http://www.gsk.com/investors/product_pipeline/docs/gsk-pipeline-feb09.pdf DMZCBMS DI DMZCBMS DMZCBMS DN Iboctadekin + Rituximab DMZCBMS MI DTUGYRD DMZCBMS MN P-glycoprotein 1 (ABCB1) DMZCBMS MT DTP DMZCBMS MA Substrate DMZCBMS RN Mammalian drug efflux transporters of the ATP binding cassette (ABC) family in multidrug resistance: A review of the past decade. Cancer Lett. 2016 Jan 1;370(1):153-64. DMZCBMS RU http://www.ncbi.nlm.nih.gov/pubmed/26499806 DMZCBMS DI DMZCBMS DMZCBMS DN Iboctadekin + Rituximab DMZCBMS MI TTN9VTF DMZCBMS MN Voltage-gated sodium channel alpha Nav1.9 (SCN11A) DMZCBMS MT DTT DMZCBMS MA Blocker DMZCBMS RN New antiarrhythmic agents for atrial fibrillation and atrial flutter. Expert Opin Emerg Drugs. 2005 May;10(2):311-22. DMZCBMS RU https://pubmed.ncbi.nlm.nih.gov/15934869 DMMPFZO DI DMMPFZO DMMPFZO DN IC9.GD2.CAR.IL-15 T-cells DMMPFZO MI TT80ARU DMMPFZO MN Ganglioside GD2 (GD2) DMMPFZO MT DTT DMMPFZO MA CAR-T-Cell-Therapy DMMPFZO RN ClinicalTrials.gov (NCT03721068) Phase I Study of CAR T-Cells Targeting the GD2 With IL-15+iCaspase9 for Relapsed/Refractory Neuroblastoma DMMPFZO RU https://clinicaltrials.gov/ct2/show/NCT03721068 DMP1ZF8 DI DMP1ZF8 DMP1ZF8 DN IC9-CAR19 cells DMP1ZF8 MI TTW640A DMP1ZF8 MN B-lymphocyte surface antigen B4 (CD19) DMP1ZF8 MT DTT DMP1ZF8 MA CAR-T-Cell-Therapy DMP1ZF8 RN ClinicalTrials.gov (NCT03016377) Administration of Autologous CAR-T CD19 Antigen With Inducible Safety Switch in Patients With Relapsed/Refractory Acute Lymphoblastic Leukemia DMP1ZF8 RU https://clinicaltrials.gov/ct2/show/NCT03016377 DMNCBIU DI DMNCBIU DMNCBIU DN IC9-CAR19 T cells DMNCBIU MI TTW640A DMNCBIU MN B-lymphocyte surface antigen B4 (CD19) DMNCBIU MT DTT DMNCBIU MA CAR-T-Cell-Therapy DMNCBIU RN ClinicalTrials.gov (NCT03696784) Anti-CD19 CAR-T Cells With Inducible Caspase 9 Safety Switch for B-cell Lymphoma DMNCBIU RU https://clinicaltrials.gov/ct2/show/NCT03696784 DMRYHWA DI DMRYHWA DMRYHWA DN IC9-GD2-CD28-OX40 DMRYHWA MI TT80ARU DMRYHWA MN Ganglioside GD2 (GD2) DMRYHWA MT DTT DMRYHWA MA CAR-T-Cell-Therapy DMRYHWA RN ClinicalTrials.gov (NCT01822652) 3rd Generation GD-2 Chimeric Antigen Receptor and iCaspase Suicide Safety Switch, Neuroblastoma, GRAIN DMRYHWA RU https://clinicaltrials.gov/ct2/show/NCT01822652 DMHG4Q9 DI DMHG4Q9 DMHG4Q9 DN ICAR19 CAR-T cells DMHG4Q9 MI TTW640A DMHG4Q9 MN B-lymphocyte surface antigen B4 (CD19) DMHG4Q9 MT DTT DMHG4Q9 MA CAR-T-Cell-Therapy DMHG4Q9 RN ClinicalTrials.gov (NCT03383952) A Clinical Study of CD19 Targeted CAR-T for Patients With CD19+ Lymphoma and Leukemia DMHG4Q9 RU https://clinicaltrials.gov/ct2/show/NCT03383952 DM3YZCV DI DM3YZCV DM3YZCV DN ICAR30 T cells DM3YZCV MI TT2GM5R DM3YZCV MN Lymphocyte activation antigen CD30 (TNFRSF8) DM3YZCV MT DTT DM3YZCV MA CAR-T-Cell-Therapy DM3YZCV RN ClinicalTrials.gov (NCT03383965) CD30 Targeted CAR-T in Treating CD30-Expressing Lymphomas DM3YZCV RU https://clinicaltrials.gov/ct2/show/NCT03383965 DMY6V5T DI DMY6V5T DMY6V5T DN ICasp9M28z T cell DMY6V5T MI TT4RXME DMY6V5T MN Mesothelin (MSLN) DMY6V5T MT DTT DMY6V5T MA CAR-T-Cell-Therapy DMY6V5T RN ClinicalTrials.gov (NCT02414269) Malignant Pleural Disease Treated With Autologous T Cells Genetically Engineered to Target the Cancer-Cell Surface Antigen Mesothelin DMY6V5T RU https://clinicaltrials.gov/ct2/show/NCT02414269 DM79W8K DI DM79W8K DM79W8K DN ICo-007 DM79W8K MI TTAN5W2 DM79W8K MN Raf messenger RNA (Raf mRNA) DM79W8K MT DTT DM79W8K RN Clinical pipeline report, company report or official report of ISIS Pharmaceuticals (2009). DM79W8K RU http://www.isispharm.com/Pipeline/index.htm DM64LVS DI DM64LVS DM64LVS DN ICT-121 DM64LVS MI TTXMZ81 DM64LVS MN Prominin-1 (PROM1) DM64LVS MT DTT DM64LVS RN Immunotargeting of cancer stem cells. Contemp Oncol (Pozn) 2015; 19(1A): A52-A59. DM64LVS RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4322523/ DMNWPMO DI DMNWPMO DMNWPMO DN IDH305 DMNWPMO MI TTV2A1R DMNWPMO MN Oxalosuccinate decarboxylase (IDH1) DMNWPMO MT DTT DMNWPMO MA Inhibitor DMNWPMO RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMNWPMO RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DM1RNT7 DI DM1RNT7 DM1RNT7 DN IDR-1018 DM1RNT7 MI TTXT4D5 DM1RNT7 MN Bacterial Cell membrane (Bact CM) DM1RNT7 MT DTT DM1RNT7 MA Regulator DM1RNT7 RN Innate Defense Regulator Peptide 1018 in Wound Healing and Wound Infection. PLoS One. 2012; 7(8): e39373. DM1RNT7 RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3412849/ DMYG3PZ DI DMYG3PZ DMYG3PZ DN IDX-189 DMYG3PZ MI TTMVBWH DMYG3PZ MN Hepatitis C virus RNA-directed RNA polymerase (HCV NS5B) DMYG3PZ MT DTT DMYG3PZ MA Inhibitor DMYG3PZ RN Clinical pipeline report, company report or official report of Idenix (2011). DMYG3PZ RU http://www.idenix.com/ DMMPINS DI DMMPINS DMMPINS DN IGM-2323 DMMPINS MI TTUE541 DMMPINS MN Leukocyte surface antigen Leu-16 (CD20) DMMPINS MT DTT DMMPINS MA Inhibitor DMMPINS RN Clinical pipeline report, company report or official report of IGM Biosciences. DMMPINS RU https://igmbio.com/pipeline/cd20-x-dc3/ DMMPINS DI DMMPINS DMMPINS DN IGM-2323 DMMPINS MI TTUN7MC DMMPINS MN T-cell surface glycoprotein CD3 (CD3) DMMPINS MT DTT DMMPINS MA Inhibitor DMMPINS RN Clinical pipeline report, company report or official report of IGM Biosciences. DMMPINS RU https://igmbio.com/pipeline/cd20-x-dc3/ DMFJXDZ DI DMFJXDZ DMFJXDZ DN IGM-8444 DMFJXDZ MI TTW20TU DMFJXDZ MN TRAIL receptor 2 (TRAIL-R2) DMFJXDZ MT DTT DMFJXDZ MA Agonist DMFJXDZ RN Clinical pipeline report, company report or official report of IGM Biosciences. DMFJXDZ RU https://igmbio.com/pipeline/death-receptor-5/ DM1MY26 DI DM1MY26 DM1MY26 DN IGN523 DM1MY26 MI TT5CZSM DM1MY26 MN Lymphocyte activation antigen 4F2 (SLC3A2) DM1MY26 MT DTT DM1MY26 RN Antitumor activity of an anti-CD98 antibody. Int J Cancer. 2015 Aug 1;137(3):710-20. DM1MY26 RU https://pubmed.ncbi.nlm.nih.gov/25556716 DMDU54Y DI DMDU54Y DMDU54Y DN IK-175 DMDU54Y MI TT037IE DMDU54Y MN Aryl hydrocarbon receptor (AHR) DMDU54Y MT DTT DMDU54Y MA Antagonist DMDU54Y RN Clinical pipeline report, company report or official report of Ikena Oncology. DMDU54Y RU https://ikenaoncology.com/pipeline/immunotherapy/ahr-antagonist-program/ DMQ01MP DI DMQ01MP DMQ01MP DN ILV-095 DMQ01MP MI TTLDX4N DMQ01MP MN Interleukin-22 (IL22) DMQ01MP MT DTT DMQ01MP RN Emerging Therapies for the Treatment of Psoriasis. Dermatol Ther (Heidelb) 2012 December; 2(1): 16. DMQ01MP RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3510410/ DM4MY9C DI DM4MY9C DM4MY9C DN IM156 DM4MY9C MI TTLAFZV DM4MY9C MN AMP-activated protein kinase (AMPK) DM4MY9C MT DTT DM4MY9C MA Inhibitor DM4MY9C RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DM4MY9C RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DM43X0Q DI DM43X0Q DM43X0Q DN IM19 DM43X0Q MI TTW640A DM43X0Q MN B-lymphocyte surface antigen B4 (CD19) DM43X0Q MT DTT DM43X0Q MA CAR-T-Cell-Therapy DM43X0Q RN ClinicalTrials.gov (NCT03528421) Assessment of Safety and Efficacy of IM19 for Relapsed or Refractory NHL Patients DM43X0Q RU https://clinicaltrials.gov/ct2/show/NCT03528421 DMTNYIB DI DMTNYIB DMTNYIB DN IM21 CART DMTNYIB MI TTZ3P4W DMTNYIB MN B-cell maturation protein (TNFRSF17) DMTNYIB MT DTT DMTNYIB MA CAR-T-Cell-Therapy DMTNYIB RN ClinicalTrials.gov (NCT03711864) Safety and Efficacy of IM21 Car-t Cells in Patients With Recurrent or Refractory BCMA Positive Multiple Myeloma DMTNYIB RU https://clinicaltrials.gov/ct2/show/NCT03711864 DML5O7T DI DML5O7T DML5O7T DN IM23 DML5O7T MI TTENHJ0 DML5O7T MN Interleukin 3 receptor alpha (IL3RA) DML5O7T MT DTT DML5O7T MA CAR-T-Cell-Therapy DML5O7T RN ClinicalTrials.gov (NCT03585517) Safety and Efficacy Evaluation of IM23 CAR-T Cells (IM23CAR-T) DML5O7T RU https://clinicaltrials.gov/ct2/show/NCT03585517 DMD9U5Q DI DMD9U5Q DMD9U5Q DN IMA 203 DMD9U5Q MI TTPH7T0 DMD9U5Q MN Tumor expressed melanoma antigen (PRAME) DMD9U5Q MT DTT DMD9U5Q RN Clinical pipeline report, company report or official report of Immatics. DMD9U5Q RU https://immatics.com/our-pipeline/ DMWSI04 DI DMWSI04 DMWSI04 DN IMC-002 DMWSI04 MI TT28S46 DMWSI04 MN Leukocyte surface antigen CD47 (CD47) DMWSI04 MT DTT DMWSI04 MA Blocker DMWSI04 RN Clinical pipeline report, company report or official report of ImmuneOncia Therapeutics. DMWSI04 RU http://www.immuneoncia.com/immun/index.php/pipeline/ DMXI5ON DI DMXI5ON DMXI5ON DN IMC-3C5 DMXI5ON MI TTDCBX5 DMXI5ON MN Vascular endothelial growth factor receptor 3 (FLT-4) DMXI5ON MT DTT DMXI5ON MA Modulator DMXI5ON RN Bevacizumab and breast cancer: what does the future hold . Future Oncol. 2012 April; 8(4): 403-414. DMXI5ON RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3464486/ DMUYN26 DI DMUYN26 DMUYN26 DN IMC-CS4 DMUYN26 MI TT731LW DMUYN26 MN Colony stimulating factor-1 receptor (CSF-1R) DMUYN26 MT DTT DMUYN26 MA Modulator DMUYN26 RN Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41. DMUYN26 RU https://www.ncbi.nlm.nih.gov/pubmed/15950434 DMCZQNJ DI DMCZQNJ DMCZQNJ DN IMC-EB10 DMCZQNJ MI TTGJCWZ DMCZQNJ MN Fms-like tyrosine kinase 3 (FLT-3) DMCZQNJ MT DTT DMCZQNJ RN IMC-EB10, an anti-FLT3 monoclonal antibody, prolongs survival and reduces nonobese diabetic/severe combined immunodeficient engraftment of some acute lymphoblastic leukemia cell lines and primary leukemic samples. Cancer Res. 2006 May 1;66(9):4843-51. DMCZQNJ RU https://pubmed.ncbi.nlm.nih.gov/16651440 DMOFSLE DI DMOFSLE DMOFSLE DN IMD-0354 DMOFSLE MI TTJ3E9X DMOFSLE MN Inhibitor of nuclear factor kappa-B kinase beta (IKKB) DMOFSLE MT DTT DMOFSLE MA Inhibitor DMOFSLE RN I B kinase beta inhibitor IMD-0354 suppresses airway remodelling in a Dermatophagoides pteronyssinus-sensitized mouse model of chronic asthma. Clin Exp Allergy. 2011 Jan;41(1):104-15. DMOFSLE RU https://pubmed.ncbi.nlm.nih.gov/20573155 DMUVLC4 DI DMUVLC4 DMUVLC4 DN IMGC936 DMUVLC4 MI TTTYQNS DMUVLC4 MN Cellular disintegrin-related protein (ADAM9) DMUVLC4 MT DTT DMUVLC4 MA Inhibitor DMUVLC4 RN Clinical pipeline report, company report or official report of ImmunoGen. DMUVLC4 RU https://www.immunogen.com/category/imgc936/ DMT9MHE DI DMT9MHE DMT9MHE DN IMGN289 DMT9MHE MI TTGKNB4 DMT9MHE MN Epidermal growth factor receptor (EGFR) DMT9MHE MT DTT DMT9MHE MA Inhibitor DMT9MHE RN World Antibody-Drug Conjugate Summit, October 15-16, 2013, San Francisco, CA. MAbs. 2014 January 1; 6(1): 18-29. DMT9MHE RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3929441/ DMSYB83 DI DMSYB83 DMSYB83 DN IMGN-388 DMSYB83 MI TTT1R2L DMSYB83 MN Integrin alpha-V (ITGAV) DMSYB83 MT DTT DMSYB83 RN Anti-alphav integrin monoclonal antibody intetumumab enhances the efficacy of radiation therapy and reduces metastasis of human cancer xenografts in nude rats. Cancer Res. 2010 Oct 1;70(19):7591-9. DMSYB83 RU https://pubmed.ncbi.nlm.nih.gov/20841470 DMR8OG2 DI DMR8OG2 DMR8OG2 DN IMGN-853 DMR8OG2 MI TTVC37M DMR8OG2 MN Folate receptor alpha (FOLR1) DMR8OG2 MT DTT DMR8OG2 MA Inhibitor DMR8OG2 RN Tumor delivery and in vivo processing of disulfide-linked and thioether-linked antibody-maytansinoid conjugates. Bioconjug Chem. 2010 Jan;21(1):84-92. DMR8OG2 RU https://pubmed.ncbi.nlm.nih.gov/19891424 DMTFUM4 DI DMTFUM4 DMTFUM4 DN IMMU-114 DMTFUM4 MI TTYA75N DMTFUM4 MN MHC class II antigen DR (HLA-DR) DMTFUM4 MT DTT DMTFUM4 RN The humanized anti-HLA-DR moAb, IMMU-114, depletes APCs and reduces alloreactive T cells: implications for preventing GVHD. Bone Marrow Transplant. 2012 Jul;47(7):967-80. DMTFUM4 RU https://pubmed.ncbi.nlm.nih.gov/22020022 DMEHWPC DI DMEHWPC DMEHWPC DN IMO-9200 DMEHWPC MI TTOK0LR DMEHWPC MN Toll-like receptor (TLR) DMEHWPC MT DTT DMEHWPC MA Antagonist DMEHWPC RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMEHWPC RU http://phrma-docs.phrma.org/files/dmfile/medicines-in-development-drug-list-autoimmune-diseases.pdf DMXSMF9 DI DMXSMF9 DMXSMF9 DN IMP-701 DMXSMF9 MI TTNVXAW DMXSMF9 MN Lymphocyte activation gene 3 protein (LAG3) DMXSMF9 MT DTT DMXSMF9 RN IMP321 (sLAG-3), an immunopotentiator for T cell responses against a HBsAg antigen in healthy adults: a single blind randomised controlled phase I study. J Immune Based Ther Vaccines. 2007 Mar 29;5:5. DMXSMF9 RU https://pubmed.ncbi.nlm.nih.gov/17394654 DMPXOVA DI DMPXOVA DMPXOVA DN IN10018 DMPXOVA MI TTON5IT DMPXOVA MN Focal adhesion kinase 1 (FAK) DMPXOVA MT DTT DMPXOVA MA Inhibitor DMPXOVA RN Clinical pipeline report, company report or official report of InxMed. DMPXOVA RU http://en.inxmed.com/intro/3.html DMCQTLG DI DMCQTLG DMCQTLG DN INB03 DMCQTLG MI TTF8CQI DMCQTLG MN Tumor necrosis factor (TNF) DMCQTLG MT DTT DMCQTLG MA Inhibitor DMCQTLG RN Clinical pipeline report, company report or official report of INmune Bio. DMCQTLG RU https://inmunebio.com/index.php/en/science/inb03/overview DM2FH10 DI DM2FH10 DM2FH10 DN INBRX-105 DM2FH10 MI TTPW9LJ DM2FH10 MN Co-stimulatory molecule 4-1BB (CD137) DM2FH10 MT DTT DM2FH10 MA Agonist DM2FH10 RN Clinical pipeline report, company report or official report of Inhibrx. DM2FH10 RU https://inhibrx.com/inbrx-105/ DM2FH10 DI DM2FH10 DM2FH10 DN INBRX-105 DM2FH10 MI TT8ZLTI DM2FH10 MN Programmed cell death 1 ligand 1 (PD-L1) DM2FH10 MT DTT DM2FH10 MA Inhibitor DM2FH10 RN Clinical pipeline report, company report or official report of Inhibrx. DM2FH10 RU https://inhibrx.com/inbrx-105/ DMUNSPI DI DMUNSPI DMUNSPI DN INBRX-109 DMUNSPI MI TTW20TU DMUNSPI MN TRAIL receptor 2 (TRAIL-R2) DMUNSPI MT DTT DMUNSPI RN Clinical pipeline report, company report or official report of Inhibrx. DMUNSPI RU https://inhibrx.com/inbrx-109/ DMDSZNC DI DMDSZNC DMDSZNC DN INCAGN2385 DMDSZNC MI TTNVXAW DMDSZNC MN Lymphocyte activation gene 3 protein (LAG3) DMDSZNC MT DTT DMDSZNC MA Inhibitor DMDSZNC RN Clinical pipeline report, company report or official report of Agenus. DMDSZNC RU https://agenusbio.com/pipeline/ DM5SO1T DI DM5SO1T DM5SO1T DN INCAGN2390 DM5SO1T MI TT1RWL7 DM5SO1T MN Hepatitis A virus cellular receptor 2 (TIM3) DM5SO1T MT DTT DM5SO1T MA Inhibitor DM5SO1T RN Clinical pipeline report, company report or official report of Agenus. DM5SO1T RU https://agenusbio.com/pipeline/ DMW7CLY DI DMW7CLY DMW7CLY DN INCB15050 DMW7CLY MI TT2CEJG DMW7CLY MN C-C chemokine receptor type 5 (CCR5) DMW7CLY MT DTT DMW7CLY MA Antagonist DMW7CLY RN Incyte. Product Development Pipeline. DMW7CLY RU http://www.incyte.com/drugs_product_pipeline.html DMFOXGB DI DMFOXGB DMFOXGB DN INCB81776 DMFOXGB MI TTO7LKR DMFOXGB MN Tyrosine-protein kinase Mer (MERTK) DMFOXGB MT DTT DMFOXGB MA Inhibitor DMFOXGB RN A Potent and Selective Dual Inhibitor of AXL and MERTK Possesses Both Immunomodulatory and Tumor-Targeted Activity. Front Oncol. 2020 Dec 7;10:598477. DMFOXGB RU https://pubmed.ncbi.nlm.nih.gov/33425754 DMFOXGB DI DMFOXGB DMFOXGB DN INCB81776 DMFOXGB MI TTZPY6J DMFOXGB MN Tyrosine-protein kinase UFO (AXL) DMFOXGB MT DTT DMFOXGB MA Inhibitor DMFOXGB RN A Potent and Selective Dual Inhibitor of AXL and MERTK Possesses Both Immunomodulatory and Tumor-Targeted Activity. Front Oncol. 2020 Dec 7;10:598477. DMFOXGB RU https://pubmed.ncbi.nlm.nih.gov/33425754 DM5WCBM DI DM5WCBM DM5WCBM DN ING-1 DM5WCBM MI TTZ8WH4 DM5WCBM MN Tumor-associated calcium signal transducer 1 (EPCAM) DM5WCBM MT DTT DM5WCBM RN ING-1, a monoclonal antibody targeting Ep-CAM in patients with advanced adenocarcinomas. Clin Cancer Res. 2004 Nov 15;10(22):7555-65. DM5WCBM RU https://pubmed.ncbi.nlm.nih.gov/15569986 DM601GL DI DM601GL DM601GL DN INNO-105 DM601GL MI TT6IEYX DM601GL MN Opioid receptor zeta (OGFR) DM601GL MT DTT DM601GL MA Modulator DM601GL RN National Cancer Institute Drug Dictionary (drug id 428488). DM601GL RU http://www.cancer.gov/publications/dictionaries/cancer-drug?cdrid=428488 DMG6S8U DI DMG6S8U DMG6S8U DN INNO-305 DMG6S8U MI TTZ8UT4 DMG6S8U MN Wilms tumor protein (WT1) DMG6S8U MT DTT DMG6S8U MA Modulator DMG6S8U RN Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800023753) DMG6S8U RU http://adisinsight.springer.com/drugs/800023753 DM90P1K DI DM90P1K DM90P1K DN INO-3401 DM90P1K MI TTUTN1I DM90P1K MN Human Deoxyribonucleic acid (hDNA) DM90P1K MT DTT DM90P1K RN ClinicalTrials.gov (NCT01403155) A Follow-On Study With an H5 Influenza Vaccine for Subjects Who Participated in Study FLU-001. U.S. National Institutes of Health. DM90P1K RU https://clinicaltrials.gov/ct2/show/NCT01403155 DMP6I9T DI DMP6I9T DMP6I9T DN INO-3510 DMP6I9T MI TTUTN1I DMP6I9T MN Human Deoxyribonucleic acid (hDNA) DMP6I9T MT DTT DMP6I9T RN Inovio Receives U.S. Patent for SynCon H1N1 Influenza Universal Vaccine. Inovio. March 26, 2012. DMP6I9T RU http://www.prnewswire.com/news-releases/inovio-receives-us-patent-for-syncon-h1n1-influenza-universal-vaccine-144185625.html DMA46DO DI DMA46DO DMA46DO DN INS-117548 DMA46DO MI TTZN7RP DMA46DO MN Rho-associated protein kinase 1 (ROCK1) DMA46DO MT DTT DMA46DO MA Modulator DMA46DO RN Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41. DMA46DO RU https://www.ncbi.nlm.nih.gov/pubmed/15950434 DMA46DO DI DMA46DO DMA46DO DN INS-117548 DMA46DO MI TTGWKQJ DMA46DO MN Rho-associated protein kinase 2 (ROCK2) DMA46DO MT DTT DMA46DO MA Modulator DMA46DO RN Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41. DMA46DO RU https://www.ncbi.nlm.nih.gov/pubmed/15950434 DMMR7CH DI DMMR7CH DMMR7CH DN Insulin oral sublingual DMMR7CH MI TTCBFJO DMMR7CH MN Insulin receptor (INSR) DMMR7CH MT DTT DMMR7CH MA Modulator DMMR7CH RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1800). DMMR7CH RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1800 DM93QP2 DI DM93QP2 DM93QP2 DN Insulin transdermal DM93QP2 MI TTCBFJO DM93QP2 MN Insulin receptor (INSR) DM93QP2 MT DTT DM93QP2 MA Modulator DM93QP2 RN Transdermal drug delivery of insulin with ultradeformable carriers. Clin Pharmacokinet. 2003;42(5):461-74. DM93QP2 RU https://pubmed.ncbi.nlm.nih.gov/12739984 DMXPLMN DI DMXPLMN DMXPLMN DN INTOPLICINE DMXPLMN MI TTGTQHC DMXPLMN MN DNA topoisomerase I (TOP1) DMXPLMN MT DTT DMXPLMN MA Modulator DMXPLMN RN Dual topoisomerase I and II inhibition by intoplicine (RP-60475), a new antitumor agent in early clinical trials. Mol Pharmacol. 1993 Oct;44(4):767-74. DMXPLMN RU https://www.ncbi.nlm.nih.gov/pubmed/8232227 DMU03WD DI DMU03WD DMU03WD DN IO-202 DMU03WD MI TTREOKA DMU03WD MN Leukocyte immunoglobulin-like receptor B4 (LILRB4) DMU03WD MT DTT DMU03WD MA Inhibitor DMU03WD RN Clinical pipeline report, company report or official report of Immune-Onc Therapeutics. DMU03WD RU https://www.immune-onc.com/news/2020-09-16-io-202-fpi DMNBPKS DI DMNBPKS DMNBPKS DN Iofolastat I-124 DMNBPKS MI TT9G4N0 DMNBPKS MN Glutamate carboxypeptidase II (GCPII) DMNBPKS MT DTT DMNBPKS MA Inhibitor DMNBPKS RN 123I-MIP-1072, a small-molecule inhibitor of prostate-specific membrane antigen, is effective at monitoring tumor response to taxane therapy. J Nucl Med. 2011 Jul;52(7):1087-93. DMNBPKS RU https://pubmed.ncbi.nlm.nih.gov/21680691 DMY0QL7 DI DMY0QL7 DMY0QL7 DN Iomab-ACT DMY0QL7 MI TTUS45N DMY0QL7 MN Leukocyte common antigen (PTPRC) DMY0QL7 MT DTT DMY0QL7 MA Inhibitor DMY0QL7 RN Clinical pipeline report, company report or official report of Actinium Pharmaceuticals. DMY0QL7 RU https://www.actiniumpharma.com/product-pipeline/iomab-b DMD7LHM DI DMD7LHM DMD7LHM DN ION 224 DMD7LHM MI TT8N5V1 DMD7LHM MN DGAT2 messenger RNA (DGAT2 mRNA) DMD7LHM MT DTT DMD7LHM MA Inhibitor DMD7LHM RN Clinical pipeline report, company report or official report of Ionis Pharmaceuticals. DMD7LHM RU https://www.ionispharma.com/ionis-innovation/pipeline/ DMGN96R DI DMGN96R DMGN96R DN Ipafricept DMGN96R MI TTVZ87F DMGN96R MN Wnt protein (WNT) DMGN96R MT DTT DMGN96R MA Modulator DMGN96R RN Clinical pipeline report, company report or official report of OncoMed Pharmaceuticals. DMGN96R RU http://www.oncomed.com/Pipeline.html DMFEI6T DI DMFEI6T DMFEI6T DN IPH5201 DMFEI6T MI TTYM8DJ DMFEI6T MN Ectonucleoside triphosphate diphosphohydrolase 1 (CD39) DMFEI6T MT DTT DMFEI6T MA Inhibitor DMFEI6T RN ClinicalTrials.gov (NCT04261075) IPH5201 as Monotherapy or in Combination With Durvalumab +/- Oleclumab in Subjects With Advanced Solid Tumors.. U.S. National Institutes of Health. DMFEI6T RU https://clinicaltrials.gov/ct2/show/NCT04261075 DMEIM5G DI DMEIM5G DMEIM5G DN IPI-940 DMEIM5G MI TTDP1UC DMEIM5G MN Fatty acid amide hydrolase (FAAH) DMEIM5G MT DTT DMEIM5G MA Inhibitor DMEIM5G RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1400). DMEIM5G RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1400 DMPKH6Y DI DMPKH6Y DMPKH6Y DN IPL 550,260 DMPKH6Y MI TTO0YVN DMPKH6Y MN Leukocyte (WBC) DMPKH6Y MT DTT DMPKH6Y MA Modulator DMPKH6Y RN WO patent application no. 2005,0792,17, Oligonucleotide decoys and methods of use. DMPKH6Y RU http://worldwide.espacenet.com/publicationDetails/biblio?DB=worldwide.espacenet.com&II=0&ND=3&adjacent=true&locale=en_EP&FT=D&date=20050901&CC=WO&NR=2005079217A2&KC=A2 DMHW1LI DI DMHW1LI DMHW1LI DN Iptakalim DMHW1LI MI TT1VOHK DMHW1LI MN Potassium channel unspecific (KC) DMHW1LI MT DTT DMHW1LI MA Opener DMHW1LI RN Iptakalim: A novel multi-utility potassium channel opener. J Pharmacol Pharmacother. 2012 Jan;3(1):12-4. DMHW1LI RU https://pubmed.ncbi.nlm.nih.gov/22368410 DMET0H4 DI DMET0H4 DMET0H4 DN IQB-9302 DMET0H4 MI TTW0CMT DMET0H4 MN Voltage-gated potassium channel Kv1.5 (KCNA5) DMET0H4 MT DTT DMET0H4 MA Opener DMET0H4 RN Stereoselective effects of the enantiomers of a new local anaesthetic, IQB-9302, on a human cardiac potassium channel (Kv1.5). Br J Pharmacol. 2001 Jan;132(2):385-92. DMET0H4 RU https://pubmed.ncbi.nlm.nih.gov/11159686 DMHP71R DI DMHP71R DMHP71R DN IQ-DAA DMHP71R MI TTIQSC1 DMHP71R MN Bacterial Lethal factor (Bact lef) DMHP71R MT DTT DMHP71R MA Modulator DMHP71R RN Anti-toxin antibodies in prophylaxis and treatment of inhalation anthrax.Future Microbiol.2009 Feb;4(1):35-43. DMHP71R RU https://www.ncbi.nlm.nih.gov/pubmed/19207098 DMHP71R DI DMHP71R DMHP71R DN IQ-DAA DMHP71R MI TT3YGCD DMHP71R MN Bacterial Protective antigen (Bact pagA) DMHP71R MT DTT DMHP71R MA Modulator DMHP71R RN Anti-toxin antibodies in prophylaxis and treatment of inhalation anthrax.Future Microbiol.2009 Feb;4(1):35-43. DMHP71R RU https://www.ncbi.nlm.nih.gov/pubmed/19207098 DMR3E4L DI DMR3E4L DMR3E4L DN Irdabisant DMR3E4L MI TT9JNIC DMR3E4L MN Histamine H3 receptor (H3R) DMR3E4L MT DTT DMR3E4L MA Antagonist DMR3E4L RN CEP-26401 (irdabisant), a potent and selective histamine H receptor antagonist/inverse agonist with cognition-enhancing and wake-promoting activities. J Pharmacol Exp Ther. 2012 Jan;340(1):124-33. DMR3E4L RU https://pubmed.ncbi.nlm.nih.gov/22001260 DM5YUOM DI DM5YUOM DM5YUOM DN Irofulven/Taxotere DM5YUOM MI TTJGNVC DM5YUOM MN Apoptosis regulator Bcl-2 (BCL-2) DM5YUOM MT DTT DM5YUOM MA Modulator DM5YUOM RN Antitumor activity of irofulven monotherapy and in combination with mitoxantrone or docetaxel against human prostate cancer models. Prostate. 2004 Apr 1;59(1):22-32. DM5YUOM RU https://pubmed.ncbi.nlm.nih.gov/14991863 DM5YUOM DI DM5YUOM DM5YUOM DN Irofulven/Taxotere DM5YUOM MI TT63KYR DM5YUOM MN Tubulin beta-1 chain (TUBB1) DM5YUOM MT DTT DM5YUOM MA Modulator DM5YUOM RN Antitumor activity of irofulven monotherapy and in combination with mitoxantrone or docetaxel against human prostate cancer models. Prostate. 2004 Apr 1;59(1):22-32. DM5YUOM RU https://pubmed.ncbi.nlm.nih.gov/14991863 DM9SCME DI DM9SCME DM9SCME DN IRX4204 DM9SCME MI TTP7WQM DM9SCME MN Retinoic acid receptor RXR (RXR) DM9SCME MT DTT DM9SCME MA Agonist DM9SCME RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DM9SCME RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DM9SCME DI DM9SCME DM9SCME DN IRX4204 DM9SCME MI TTH029C DM9SCME MN Retinoic acid receptor RXR-gamma (RXRG) DM9SCME MT DTT DM9SCME MA Modulator DM9SCME RN Selective brain penetrable Nurr1 transactivator for treating Parkinson's disease.Oncotarget.2016 Feb 16;7(7):7469-79. DM9SCME RU https://www.ncbi.nlm.nih.gov/pubmed/26862735 DMCED9U DI DMCED9U DMCED9U DN IRX-5183 DMCED9U MI TTW38KT DMCED9U MN Retinoic acid receptor alpha (RARA) DMCED9U MT DTT DMCED9U MA Agonist DMCED9U RN Retinoic acid receptor alpha and retinoid X receptor specific agonists reduce renal injury in established chronic glomerulonephritis of the rat. J Mol Med (Berl). 2004 Feb;82(2):116-25. DMCED9U RU https://pubmed.ncbi.nlm.nih.gov/14712350 DMCED9U DI DMCED9U DMCED9U DN IRX-5183 DMCED9U MI TTP7WQM DMCED9U MN Retinoic acid receptor RXR (RXR) DMCED9U MT DTT DMCED9U MA Agonist DMCED9U RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMCED9U RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DMKO7EA DI DMKO7EA DMKO7EA DN ISF-402 DMKO7EA MI TTCBFJO DMKO7EA MN Insulin receptor (INSR) DMKO7EA MT DTT DMKO7EA MA Modulator DMKO7EA RN Ability of GHTD-amide and analogs to enhance insulin activity through zinc chelation and dispersal of insulin oligomers. Peptides. 2009 Jun;30(6):1088-97. DMKO7EA RU https://pubmed.ncbi.nlm.nih.gov/19463741 DMEJ4B7 DI DMEJ4B7 DMEJ4B7 DN ISIS 325568 DMEJ4B7 MI TTLMJSC DMEJ4B7 MN Glucagon receptor messenger RNA (GCGR mRNA) DMEJ4B7 MT DTT DMEJ4B7 RN Design and development of antisense drugs. Expert Opin. Drug Discov. 2008 3(10):1189-1207. DMEJ4B7 RU http://www.informahealthcare.com/doi/abs/10.1517/17460441.3.10.1177 DM9Y51T DI DM9Y51T DM9Y51T DN ISIS-ANGPTL3 DM9Y51T MI TT59GO7 DM9Y51T MN ANGPTL3 messenger RNA (ANGPTL3 mRNA) DM9Y51T MT DTT DM9Y51T RN Clinical pipeline report, company report or official report of ISIS Pharmaceuticals. DM9Y51T RU https://www.isispharm.com/pipeline/isis-angptl3rx/ DMX3FN4 DI DMX3FN4 DMX3FN4 DN ISIS-APOCIII DMX3FN4 MI TTXOZQ1 DMX3FN4 MN ApoC-III messenger RNA (APOC3 mRNA) DMX3FN4 MT DTT DMX3FN4 RN Clinical pipeline report, company report or official report of ISIS Pharmaceuticals (2011). DMX3FN4 RU http://www.isispharm.com/index.htm DM8P3N5 DI DM8P3N5 DM8P3N5 DN ISIS-AR DM8P3N5 MI TTKPW01 DM8P3N5 MN Androgen receptor messenger RNA (AR mRNA) DM8P3N5 MT DTT DM8P3N5 RN Clinical pipeline report, company report or official report of ISIS Pharmaceuticals. DM8P3N5 RU https://www.isispharm.com/pipeline/isis-arrx/ DMQDUG4 DI DMQDUG4 DMQDUG4 DN ISIS-CRP DMQDUG4 MI TTWRN6M DMQDUG4 MN CRP messenger RNA (CRP mRNA) DMQDUG4 MT DTT DMQDUG4 RN Clinical pipeline report, company report or official report of ISIS Pharmaceuticals (2009). DMQDUG4 RU http://www.isispharm.com/Pipeline/index.htm DMQDUG4 DI DMQDUG4 DMQDUG4 DN ISIS-CRP DMQDUG4 MI TT860QF DMQDUG4 MN LCK tyrosine protein kinase (LCK) DMQDUG4 MT DTT DMQDUG4 MA Inhibitor DMQDUG4 RN The selectivity of protein kinase inhibitors: a further update. Biochem J. 2007 Dec 15;408(3):297-315. DMQDUG4 RU https://pubmed.ncbi.nlm.nih.gov/17850214 DMQDUG4 DI DMQDUG4 DMQDUG4 DN ISIS-CRP DMQDUG4 MI TT6PKBN DMQDUG4 MN Proto-oncogene c-Src (SRC) DMQDUG4 MT DTT DMQDUG4 MA Inhibitor DMQDUG4 RN The selectivity of protein kinase inhibitors: a further update. Biochem J. 2007 Dec 15;408(3):297-315. DMQDUG4 RU https://pubmed.ncbi.nlm.nih.gov/17850214 DMQDUG4 DI DMQDUG4 DMQDUG4 DN ISIS-CRP DMQDUG4 MI TTCQ2E5 DMQDUG4 MN RIP2 messenger RNA (RIP2 mRNA) DMQDUG4 MT DTT DMQDUG4 MA Inhibitor DMQDUG4 RN The selectivity of protein kinase inhibitors: a further update. Biochem J. 2007 Dec 15;408(3):297-315. DMQDUG4 RU https://pubmed.ncbi.nlm.nih.gov/17850214 DMQDUG4 DI DMQDUG4 DMQDUG4 DN ISIS-CRP DMQDUG4 MI TT3PJMV DMQDUG4 MN Tyrosine-protein kinase ABL1 (ABL) DMQDUG4 MT DTT DMQDUG4 MA Inhibitor DMQDUG4 RN Structure-based optimization of pyrazolo[3,4-d]pyrimidines as Abl inhibitors and antiproliferative agents toward human leukemia cell lines. J Med Chem. 2008 Mar 13;51(5):1252-9. DMQDUG4 RU https://pubmed.ncbi.nlm.nih.gov/18257513 DMQDUG4 DI DMQDUG4 DMQDUG4 DN ISIS-CRP DMQDUG4 MI TT6TH8V DMQDUG4 MN Tyrosine-protein kinase BRK (PTK6) DMQDUG4 MT DTT DMQDUG4 MA Inhibitor DMQDUG4 RN Inhibition of SRC tyrosine kinase impairs inherent and acquired gemcitabine resistance in human pancreatic adenocarcinoma cells. Clin Cancer Res. 2004 Apr 1;10(7):2307-18. DMQDUG4 RU https://pubmed.ncbi.nlm.nih.gov/15073106 DMDKAIC DI DMDKAIC DMDKAIC DN ISIS-SGLT2 DMDKAIC MI TTF8JAT DMDKAIC MN SLC5A2 messenger RNA (SLC5A2 mRNA) DMDKAIC MT DTT DMDKAIC RN Clinical pipeline report, company report or official report of ISIS Pharmaceuticals (2011). DMDKAIC RU http://www.isispharm.com/index.htm DMV1BTP DI DMV1BTP DMV1BTP DN ISIS-SOD1 DMV1BTP MI TTP9K3Q DMV1BTP MN SOD1 messenger RNA (SOD1 mRNA) DMV1BTP MT DTT DMV1BTP RN Clinical pipeline report, company report or official report of ISIS Pharmaceuticals (2011). DMV1BTP RU http://www.isispharm.com/index.htm DMDB7KU DI DMDB7KU DMDB7KU DN ISO-1 DMDB7KU MI TT2AST1 DMDB7KU MN Macrophage migration inhibitory factor (MIF) DMDB7KU MT DTT DMDB7KU MA Inhibitor DMDB7KU RN The tautomerase active site of macrophage migration inhibitory factor is a potential target for discovery of novel anti-inflammatory agents. J Biol Chem. 2002 Jul 12;277(28):24976-82. DMDB7KU RU https://pubmed.ncbi.nlm.nih.gov/11997397 DMBQ8CA DI DMBQ8CA DMBQ8CA DN ISO-901 DMBQ8CA MI DEL4UKY DMBQ8CA MN Methylenetetrahydrofolate dehydrogenase (folD) DMBQ8CA MT DME DMBQ8CA MA Metabolism DMBQ8CA RN nan DMBQ8CA RU nan DMBQ8CA DI DMBQ8CA DMBQ8CA DN ISO-901 DMBQ8CA MI DEH3KAT DMBQ8CA MN Methylenetetrahydrofolate reductase (metF) DMBQ8CA MT DME DMBQ8CA MA Metabolism DMBQ8CA RN Functional profiles of coronal and dentin caries in children. J Oral Microbiol. 2018 Jul 16;10(1):1495976. DMBQ8CA RU https://pubmed.ncbi.nlm.nih.gov/30034639 DMBQ8CA DI DMBQ8CA DMBQ8CA DN ISO-901 DMBQ8CA MI DEOXTPZ DMBQ8CA MN Methylenetetrahydrofolate reductase (MTHFR) DMBQ8CA MT DME DMBQ8CA MA Metabolism DMBQ8CA RN Methylenetetrahydrofolate reductase gene polymorphisms: genomic predictors of clinical response to fluoropyrimidine-based chemotherapy? Cancer Chemother Pharmacol. 2006 Jun;57(6):835-40. DMBQ8CA RU https://www.ncbi.nlm.nih.gov/pubmed/?term=16187112 DMR17YI DI DMR17YI DMR17YI DN Isoquine DMR17YI MI TTVG215 DMR17YI MN Debrisoquine 4-hydroxylase (CYP2D6) DMR17YI MT DTT DMR17YI MA Inhibitor DMR17YI RN Candidate selection and preclinical evaluation of N-tert-butyl isoquine (GSK369796), an affordable and effective 4-aminoquinoline antimalarial for ... J Med Chem. 2009 Mar 12;52(5):1408-15. DMR17YI RU https://pubmed.ncbi.nlm.nih.gov/19222165 DMR17YI DI DMR17YI DMR17YI DN Isoquine DMR17YI MI TTQ6VDM DMR17YI MN Voltage-gated potassium channel Kv11.1 (KCNH2) DMR17YI MT DTT DMR17YI MA Inhibitor DMR17YI RN Candidate selection and preclinical evaluation of N-tert-butyl isoquine (GSK369796), an affordable and effective 4-aminoquinoline antimalarial for ... J Med Chem. 2009 Mar 12;52(5):1408-15. DMR17YI RU https://pubmed.ncbi.nlm.nih.gov/19222165 DMBPV9W DI DMBPV9W DMBPV9W DN IT-139 DMBPV9W MI TTW26OG DMBPV9W MN Endoplasmic reticulum chaperone BiP (HSPA5) DMBPV9W MT DTT DMBPV9W MA Inhibitor DMBPV9W RN NKP-1339, a first-in-class anticancer drug showing mild side effects and activity in patients suffering from advanced refractory cancer. BMC Pharmacol Toxicol. 2012; 13(Suppl 1): A82. DMBPV9W RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3506350/ DMAYD7O DI DMAYD7O DMAYD7O DN IT-141 DMAYD7O MI TTGTQHC DMAYD7O MN DNA topoisomerase I (TOP1) DMAYD7O MT DTT DMAYD7O MA Inhibitor DMAYD7O RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMAYD7O RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DMY1DFK DI DMY1DFK DMY1DFK DN ITASETRON DMY1DFK MI TTNXLKE DMY1DFK MN 5-HT 3 receptor (5HT3R) DMY1DFK MT DTT DMY1DFK MA Modulator DMY1DFK RN Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41. DMY1DFK RU https://www.ncbi.nlm.nih.gov/pubmed/15950434 DM702MU DI DM702MU DM702MU DN ITX-5061 DM702MU MI DECB0K3 DM702MU MN Cytochrome P450 2D6 (CYP2D6) DM702MU MT DME DM702MU MA Metabolism DM702MU RN ITX 5061 quantitation in human plasma with reverse phase liquid chromatography and mass spectrometry detection. Antivir Ther. 2013;18(3):329-36. DM702MU RU https://www.ncbi.nlm.nih.gov/pubmed/?term=22954720 DM702MU DI DM702MU DM702MU DN ITX-5061 DM702MU MI DE4LYSA DM702MU MN Cytochrome P450 3A4 (CYP3A4) DM702MU MT DME DM702MU MA Metabolism DM702MU RN ITX 5061 quantitation in human plasma with reverse phase liquid chromatography and mass spectrometry detection. Antivir Ther. 2013;18(3):329-36. DM702MU RU https://www.ncbi.nlm.nih.gov/pubmed/?term=22954720 DM702MU DI DM702MU DM702MU DN ITX-5061 DM702MU MI DEIBDNY DM702MU MN Cytochrome P450 3A5 (CYP3A5) DM702MU MT DME DM702MU MA Metabolism DM702MU RN ITX 5061 quantitation in human plasma with reverse phase liquid chromatography and mass spectrometry detection. Antivir Ther. 2013;18(3):329-36. DM702MU RU https://www.ncbi.nlm.nih.gov/pubmed/?term=22954720 DM702MU DI DM702MU DM702MU DN ITX-5061 DM702MU MI DEGTFWK DM702MU MN Mephenytoin 4-hydroxylase (CYP2C19) DM702MU MT DME DM702MU MA Metabolism DM702MU RN ITX 5061 quantitation in human plasma with reverse phase liquid chromatography and mass spectrometry detection. Antivir Ther. 2013;18(3):329-36. DM702MU RU https://www.ncbi.nlm.nih.gov/pubmed/?term=22954720 DMSGEU6 DI DMSGEU6 DMSGEU6 DN JAB-3068 DMSGEU6 MI TT7WUAV DMSGEU6 MN Protein-tyrosine phosphatase SHP-2 (PTPN11) DMSGEU6 MT DTT DMSGEU6 MA Inhibitor DMSGEU6 RN Clinical pipeline report, company report or official report of AbbVie. DMSGEU6 RU https://www.abbvie.com/our-science/pipeline/jab-3068-jab-3312.html DM7XAV1 DI DM7XAV1 DM7XAV1 DN JBH492 DM7XAV1 MI TT2GIDQ DM7XAV1 MN C-C chemokine receptor type 7 (CCR7) DM7XAV1 MT DTT DM7XAV1 RN ClinicalTrials.gov (NCT04240704) Safety and Preliminary Efficacy of JBH492 Monotherapy in Patients With Chronic Lymphocytic Leukemia (CLL) and Non-Hodgkin's Lymphoma (NHL). U.S. National Institutes of Health. DM7XAV1 RU https://clinicaltrials.gov/ct2/show/NCT04240704 DMR3SO5 DI DMR3SO5 DMR3SO5 DN JCAR018 DMR3SO5 MI TTM6QSK DMR3SO5 MN B-cell receptor CD22 (CD22) DMR3SO5 MT DTT DMR3SO5 MA Immunomodulator DMR3SO5 RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMR3SO5 RU http://phrma-docs.phrma.org/files/dmfile/MID_Immuno-Oncology-2017_Drug-List1.pdf DM1T8KN DI DM1T8KN DM1T8KN DN JCAR020 DM1T8KN MI TTC1PS3 DM1T8KN MN Ovarian carcinoma antigen CA125 (MUC16) DM1T8KN MT DTT DM1T8KN MA Immunomodulator DM1T8KN RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DM1T8KN RU http://phrma-docs.phrma.org/files/dmfile/MID_Immuno-Oncology-2017_Drug-List1.pdf DM324RM DI DM324RM DM324RM DN JCAR023 DM324RM MI TTC9D3K DM324RM MN Neural cell adhesion molecule L1 (L1CAM) DM324RM MT DTT DM324RM MA CAR-T-Cell-Therapy DM324RM RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DM324RM RU http://phrma-docs.phrma.org/files/dmfile/MID_Immuno-Oncology-2017_Drug-List1.pdf DMYR3IE DI DMYR3IE DMYR3IE DN JES-9501 DMYR3IE MI TTEB0GD DMYR3IE MN Cholinesterase (BCHE) DMYR3IE MT DTT DMYR3IE MA Modulator DMYR3IE RN Dehydroevodiamine attenuates beta-amyloid peptide-induced amnesia in mice. Eur J Pharmacol. 2001 Feb 16;413(2-3):221-5. DMYR3IE RU https://pubmed.ncbi.nlm.nih.gov/11226396 DMMI4XR DI DMMI4XR DMMI4XR DN JNJ-17305600 DMMI4XR MI TTHJTF7 DMMI4XR MN Glycine transporter GlyT-1 (SLC6A9) DMMI4XR MT DTT DMMI4XR MA Inhibitor DMMI4XR RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 935). DMMI4XR RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=935 DMSQ3AZ DI DMSQ3AZ DMSQ3AZ DN JNJ-26483327 DMSQ3AZ MI TTGKNB4 DMSQ3AZ MN Epidermal growth factor receptor (EGFR) DMSQ3AZ MT DTT DMSQ3AZ MA Inhibitor DMSQ3AZ RN National Cancer Institute Drug Dictionary (drug id 596693). DMSQ3AZ RU http://www.cancer.gov/publications/dictionaries/cancer-drug?cdrid=596693 DMSQ3AZ DI DMSQ3AZ DMSQ3AZ DN JNJ-26483327 DMSQ3AZ MI TT6EO5L DMSQ3AZ MN Erbb2 tyrosine kinase receptor (HER2) DMSQ3AZ MT DTT DMSQ3AZ MA Inhibitor DMSQ3AZ RN National Cancer Institute Drug Dictionary (drug id 596693). DMSQ3AZ RU http://www.cancer.gov/publications/dictionaries/cancer-drug?cdrid=596693 DMSQ3AZ DI DMSQ3AZ DMSQ3AZ DN JNJ-26483327 DMSQ3AZ MI TT0JESD DMSQ3AZ MN Erbb4 tyrosine kinase receptor (Erbb-4) DMSQ3AZ MT DTT DMSQ3AZ MA Inhibitor DMSQ3AZ RN National Cancer Institute Drug Dictionary (drug id 596693). DMSQ3AZ RU http://www.cancer.gov/publications/dictionaries/cancer-drug?cdrid=596693 DMSQ3AZ DI DMSQ3AZ DMSQ3AZ DN JNJ-26483327 DMSQ3AZ MI TT2B9KF DMSQ3AZ MN Fyn tyrosine protein kinase (FYN) DMSQ3AZ MT DTT DMSQ3AZ MA Inhibitor DMSQ3AZ RN National Cancer Institute Drug Dictionary (drug id 596693). DMSQ3AZ RU http://www.cancer.gov/publications/dictionaries/cancer-drug?cdrid=596693 DMSQ3AZ DI DMSQ3AZ DMSQ3AZ DN JNJ-26483327 DMSQ3AZ MI TT860QF DMSQ3AZ MN LCK tyrosine protein kinase (LCK) DMSQ3AZ MT DTT DMSQ3AZ MA Inhibitor DMSQ3AZ RN National Cancer Institute Drug Dictionary (drug id 596693). DMSQ3AZ RU http://www.cancer.gov/publications/dictionaries/cancer-drug?cdrid=596693 DMSQ3AZ DI DMSQ3AZ DMSQ3AZ DN JNJ-26483327 DMSQ3AZ MI TT1RWNJ DMSQ3AZ MN Tyrosine-protein kinase Lyn (JTK8) DMSQ3AZ MT DTT DMSQ3AZ MA Inhibitor DMSQ3AZ RN National Cancer Institute Drug Dictionary (drug id 596693). DMSQ3AZ RU http://www.cancer.gov/publications/dictionaries/cancer-drug?cdrid=596693 DMSQ3AZ DI DMSQ3AZ DMSQ3AZ DN JNJ-26483327 DMSQ3AZ MI TTDCBX5 DMSQ3AZ MN Vascular endothelial growth factor receptor 3 (FLT-4) DMSQ3AZ MT DTT DMSQ3AZ MA Inhibitor DMSQ3AZ RN National Cancer Institute Drug Dictionary (drug id 596693). DMSQ3AZ RU http://www.cancer.gov/publications/dictionaries/cancer-drug?cdrid=596693 DMSQ3AZ DI DMSQ3AZ DMSQ3AZ DN JNJ-26483327 DMSQ3AZ MI TT0SQ8J DMSQ3AZ MN Yes tyrosine kinase (YES) DMSQ3AZ MT DTT DMSQ3AZ MA Inhibitor DMSQ3AZ RN National Cancer Institute Drug Dictionary (drug id 596693). DMSQ3AZ RU http://www.cancer.gov/publications/dictionaries/cancer-drug?cdrid=596693 DMNSJ3C DI DMNSJ3C DMNSJ3C DN JNJ-26854165 DMNSJ3C MI TT08GJW DMNSJ3C MN Ubiquitin-protein ligase E3 Mdm2 (MDM2) DMNSJ3C MT DTT DMNSJ3C MA Modulator DMNSJ3C RN Serdemetan antagonizes the Mdm2-HIF1alpha axis leading to decreased levels of glycolytic enzymes. PLoS One. 2013 Sep 6;8(9):e74741. DMNSJ3C RU https://pubmed.ncbi.nlm.nih.gov/24040331 DM49VWQ DI DM49VWQ DM49VWQ DN JNJ-3534 DM49VWQ MI TTGV6LY DM49VWQ MN Nuclear receptor ROR-gamma (RORG) DM49VWQ MT DTT DM49VWQ MA Modulator DM49VWQ RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DM49VWQ RU http://phrma-docs.phrma.org/files/dmfile/MID_Skin_Diseases_2018_9_FINAL.pdf DMDIPW8 DI DMDIPW8 DMDIPW8 DN JNJ-38877605 DMDIPW8 MI TTNDSF4 DMDIPW8 MN Proto-oncogene c-Met (MET) DMDIPW8 MT DTT DMDIPW8 MA Inhibitor DMDIPW8 RN The c-Met Tyrosine Kinase Inhibitor JNJ-38877605 Causes Renal Toxicity through Species-Specific Insoluble Metabolite Formation. Clin Cancer Res. 2015 May 15;21(10):2297-304. DMDIPW8 RU https://pubmed.ncbi.nlm.nih.gov/25745036 DM45SGE DI DM45SGE DM45SGE DN JNJ-39439335 DM45SGE MI TTMI6F5 DM45SGE MN Transient receptor potential cation channel V1 (TRPV1) DM45SGE MT DTT DM45SGE MA Antagonist DM45SGE RN Benzo[d]imidazole Transient Receptor Potential Vanilloid 1 Antagonists for the Treatment of Pain: Discovery of trans-2-(2-{2-[2-(4-Trifluoromethyl-phenyl)-vinyl]-1H-benzimidazol-5-yl}-phenyl)-propan-2-ol (Mavatrep). J Med Chem. 2015 May 14;58(9):3859-74. DM45SGE RU https://pubmed.ncbi.nlm.nih.gov/25850459 DMOL9JR DI DMOL9JR DMOL9JR DN JNJ-42491293 DMOL9JR MI TTXJ47W DMOL9JR MN Metabotropic glutamate receptor 2 (mGluR2) DMOL9JR MT DTT DMOL9JR MA Binder DMOL9JR RN Opportunities and challenges in the discovery of allosteric modulators of GPCRs for treating CNS disorders. Nat Rev Drug Discov. 2014 Sep;13(9):692-708. DMOL9JR RU https://pubmed.ncbi.nlm.nih.gov/25176435 DMQ5ZVK DI DMQ5ZVK DMQ5ZVK DN JNJ-54175446 DMQ5ZVK MI TT473XN DMQ5ZVK MN P2X purinoceptor 7 (P2RX7) DMQ5ZVK MT DTT DMQ5ZVK MA Antagonist DMQ5ZVK RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMQ5ZVK RU http://phrma-docs.phrma.org/files/dmfile/MID_Mental-Illness-2017-Drug-List_Final.pdf DMBV3P8 DI DMBV3P8 DMBV3P8 DN JNJ-54728518 DMBV3P8 MI TTVIMDE DMBV3P8 MN Glucagon-like peptide 1 receptor (GLP1R) DMBV3P8 MT DTT DMBV3P8 MA Agonist DMBV3P8 RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMBV3P8 RU http://phrma-docs.phrma.org/files/dmfile/mid-diabetes-drug-list.pdf DM0QZJX DI DM0QZJX DM0QZJX DN JNJ-55308942 DM0QZJX MI TT473XN DM0QZJX MN P2X purinoceptor 7 (P2RX7) DM0QZJX MT DTT DM0QZJX MA Inhibitor DM0QZJX RN Antibodies and venom peptides: new modalities for ion channels. Nat Rev Drug Discov. 2019 May;18(5):339-357. DM0QZJX RU https://pubmed.ncbi.nlm.nih.gov/30728472 DMSPQDM DI DMSPQDM DMSPQDM DN JNJ-61610588 DMSPQDM MI TT51SK8 DMSPQDM MN V-set immunoregulatory receptor (VSIR) DMSPQDM MT DTT DMSPQDM MA Inhibitor DMSPQDM RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMSPQDM RU http://phrma-docs.phrma.org/files/dmfile/MID_Immuno-Oncology-2017_Drug-List1.pdf DM5SZAK DI DM5SZAK DM5SZAK DN JNJ-63709178 DM5SZAK MI TTENHJ0 DM5SZAK MN Interleukin 3 receptor alpha (IL3RA) DM5SZAK MT DTT DM5SZAK MA Inhibitor DM5SZAK RN Immune therapies in acute myeloid leukemia: a focus on monoclonal antibodies and immune checkpoint inhibitors. Curr Opin Hematol. 2018 Mar;25(2):136-145. DM5SZAK RU https://pubmed.ncbi.nlm.nih.gov/29206680 DM5SZAK DI DM5SZAK DM5SZAK DN JNJ-63709178 DM5SZAK MI TTUN7MC DM5SZAK MN T-cell surface glycoprotein CD3 (CD3) DM5SZAK MT DTT DM5SZAK MA Inhibitor DM5SZAK RN Immune therapies in acute myeloid leukemia: a focus on monoclonal antibodies and immune checkpoint inhibitors. Curr Opin Hematol. 2018 Mar;25(2):136-145. DM5SZAK RU https://pubmed.ncbi.nlm.nih.gov/29206680 DMJFK6X DI DMJFK6X DMJFK6X DN JNJ-63898081 DMJFK6X MI TT9G4N0 DMJFK6X MN Glutamate carboxypeptidase II (GCPII) DMJFK6X MT DTT DMJFK6X MA Inhibitor DMJFK6X RN Clinical pipeline report, company report or official report of Genmab. DMJFK6X RU https://www.genmab.com/pipeline/ DMLYAGD DI DMLYAGD DMLYAGD DN JNJ-64264681 DMLYAGD MI TTGM6VW DMLYAGD MN Tyrosine-protein kinase BTK (ATK) DMLYAGD MT DTT DMLYAGD MA Inhibitor DMLYAGD RN A Study of JNJ-64264681 and JNJ-67856633 in Participants With Non-Hodgkin Lymphoma and Chronic Lymphocytic Leukemia DMLYAGD RU https://clinicaltrials.gov/ct2/show/NCT04657224 DMYJCUP DI DMYJCUP DMYJCUP DN JNJ-64417184 DMYJCUP MI TT6275O DMYJCUP MN HRSV RNA-directed RNA polymerase L (HRSV L) DMYJCUP MT DTT DMYJCUP MA Inhibitor DMYJCUP RN Advances in respiratory virus therapeutics - A meeting report from the 6th isirv Antiviral Group conference. Antiviral Res. 2019 Jul;167:45-67. DMYJCUP RU https://pubmed.ncbi.nlm.nih.gov/30974127 DMDBW2N DI DMDBW2N DMDBW2N DN JNJ-64619178 DMDBW2N MI TTR1D7X DMDBW2N MN Protein arginine methyltransferase 5 (PRMT5) DMDBW2N MT DTT DMDBW2N MA Inhibitor DMDBW2N RN A patent review of arginine methyltransferase inhibitors (2010-2018). Expert Opin Ther Pat. 2019 Feb;29(2):97-114. DMDBW2N RU https://pubmed.ncbi.nlm.nih.gov/30640571 DMQOHRA DI DMQOHRA DMQOHRA DN JNJ-67571244 DMQOHRA MI TTJVYO3 DMQOHRA MN Myeloid cell surface antigen CD33 (CD33) DMQOHRA MT DTT DMQOHRA MA Inhibitor DMQOHRA RN Clinical pipeline report, company report or official report of Genmab. DMQOHRA RU https://www.genmab.com/pipeline/ DM6URNJ DI DM6URNJ DM6URNJ DN JNJ-67856633 DM6URNJ MI TTCI81G DM6URNJ MN MALT lymphoma-associated translocation (MALT1) DM6URNJ MT DTT DM6URNJ MA Inhibitor DM6URNJ RN National Cancer Institute Drug Dictionary (drug name JNJ67856633). DM6URNJ RU https://www.cancer.gov/publications/dictionaries/cancer-drug/def/malt1-inhibitor-jnj-67856633 DM6VR13 DI DM6VR13 DM6VR13 DN JNJ-69086420 DM6VR13 MI TTJLNAW DM6VR13 MN Tissue kallikrein (KLK2) DM6VR13 MT DTT DM6VR13 MA Inhibitor DM6VR13 RN ClinicalTrials.gov (NCT04644770) A Study of JNJ-69086420, an Actinium-225-Labeled Antibody Targeting Human Kallikrein-2 (hK2) for Advanced Prostate Cancer. U.S. National Institutes of Health. DM6VR13 RU https://clinicaltrials.gov/ct2/show/NCT04644770 DMY7CW1 DI DMY7CW1 DMY7CW1 DN JNJ-74699157 DMY7CW1 MI TT3LH46 DMY7CW1 MN KRAS G12C mutant (KRAS G12C) DMY7CW1 MT DTT DMY7CW1 MA Inhibitor DMY7CW1 RN KRAS: From undruggable to a druggable Cancer Target. Cancer Treat Rev. 2020 Sep;89:102070. DMY7CW1 RU https://pubmed.ncbi.nlm.nih.gov/32711246 DMFMWLQ DI DMFMWLQ DMFMWLQ DN JS004 DMFMWLQ MI TTER58P DMFMWLQ MN B- and T-lymphocyte attenuator (BTLA) DMFMWLQ MT DTT DMFMWLQ MA Inhibitor DMFMWLQ RN Clinical pipeline report, company report or official report of Junshi Biosciences. DMFMWLQ RU https://www.junshipharma.com/en/Treatment.html DMVJWBS DI DMVJWBS DMVJWBS DN JSI-1187 DMVJWBS MI TT1MG9E DMVJWBS MN Extracellular signal-regulated kinase 1 (ERK1) DMVJWBS MT DTT DMVJWBS MA Inhibitor DMVJWBS RN National Cancer Institute Drug Dictionary (drug name JSI1187). DMVJWBS RU https://www.cancer.gov/publications/dictionaries/cancer-drug/def/erk1-2-inhibitor-jsi-1187 DMVJWBS DI DMVJWBS DMVJWBS DN JSI-1187 DMVJWBS MI TT4TQBX DMVJWBS MN Extracellular signal-regulated kinase 2 (ERK2) DMVJWBS MT DTT DMVJWBS MA Inhibitor DMVJWBS RN National Cancer Institute Drug Dictionary (drug name JSI1187). DMVJWBS RU https://www.cancer.gov/publications/dictionaries/cancer-drug/def/erk1-2-inhibitor-jsi-1187 DM4QIOH DI DM4QIOH DM4QIOH DN JSM 6427 DM4QIOH MI TTHIZP9 DM4QIOH MN Integrin alpha-5 (ITGA5) DM4QIOH MT DTT DM4QIOH MA Antagonist DM4QIOH RN An alpha5beta1 integrin inhibitor attenuates glioma growth. Mol Cell Neurosci. 2008 Dec;39(4):579-85. DM4QIOH RU https://pubmed.ncbi.nlm.nih.gov/18804537 DM4QIOH DI DM4QIOH DM4QIOH DN JSM 6427 DM4QIOH MI TTBVIQC DM4QIOH MN Integrin beta-1 (ITGB1) DM4QIOH MT DTT DM4QIOH MA Antagonist DM4QIOH RN An alpha5beta1 integrin inhibitor attenuates glioma growth. Mol Cell Neurosci. 2008 Dec;39(4):579-85. DM4QIOH RU https://pubmed.ncbi.nlm.nih.gov/18804537 DM01JU8 DI DM01JU8 DM01JU8 DN JTE-451 DM01JU8 MI TTGV6LY DM01JU8 MN Nuclear receptor ROR-gamma (RORG) DM01JU8 MT DTT DM01JU8 MA Antagonist DM01JU8 RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DM01JU8 RU http://phrma-docs.phrma.org/files/dmfile/MID_Skin_Diseases_2018_9_FINAL.pdf DMHMDC0 DI DMHMDC0 DMHMDC0 DN JWCAR029 DMHMDC0 MI TTW640A DMHMDC0 MN B-lymphocyte surface antigen B4 (CD19) DMHMDC0 MT DTT DMHMDC0 MA CAR-T-Cell-Therapy DMHMDC0 RN ClinicalTrials.gov (NCT03344367) Study Evaluating the Safety and Efficacy of JWCAR029 in Adult Subjects With Relapsed and Refractory B-cell Non-Hodgkin Lymphoma DMHMDC0 RU https://clinicaltrials.gov/ct2/show/NCT03344367 DMW5J9B DI DMW5J9B DMW5J9B DN JX-929 DMW5J9B MI TTKRTP6 DMW5J9B MN Cytosine deaminase (AICDA) DMW5J9B MT DTT DMW5J9B MA Modulator DMW5J9B RN Micromanaging oncolytic viruses. SciBX 1(42); doi:10.1038/scibx.2008.1014. Nov. 20 2008 DMW5J9B RU http://www.nature.com/scibx/journal/v1/n42/full/scibx.2008.1014.html DMFKEVO DI DMFKEVO DMFKEVO DN KA2237 DMFKEVO MI TTHBTOP DMFKEVO MN PI3-kinase gamma (PIK3CG) DMFKEVO MT DTT DMFKEVO MA Inhibitor DMFKEVO RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMFKEVO RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DMW0H9Y DI DMW0H9Y DMW0H9Y DN KA2507 DMW0H9Y MI TT5ZKDI DMW0H9Y MN Histone deacetylase 6 (HDAC6) DMW0H9Y MT DTT DMW0H9Y MA Inhibitor DMW0H9Y RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMW0H9Y RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DMXYN1H DI DMXYN1H DMXYN1H DN KAR5585 DMXYN1H MI TTZSJHV DMXYN1H MN Tryptophan 5-hydroxylase 1 (TPH1) DMXYN1H MT DTT DMXYN1H RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMXYN1H RU http://phrma-docs.phrma.org/files/dmfile/2018_Heart-Disease-and-Stroke_MID-Drug-List.pdf DMTYNRB DI DMTYNRB DMTYNRB DN KD033 DMTYNRB MI TT8ZLTI DMTYNRB MN Programmed cell death 1 ligand 1 (PD-L1) DMTYNRB MT DTT DMTYNRB MA Inhibitor DMTYNRB RN Clinical pipeline report, company report or official report of Kadmon. DMTYNRB RU https://kadmon.com/clinical-pipeline/pipeline/kd033/ DMNFDYE DI DMNFDYE DMNFDYE DN KD3010 DMNFDYE MI TT2JWF6 DMNFDYE MN Peroxisome proliferator-activated receptor delta (PPARD) DMNFDYE MT DTT DMNFDYE MA Agonist DMNFDYE RN Kalypsys nearing completion of phase Ia study of KD3010 for metabolic disorders. Kalypsys. 2007. DMNFDYE RU http://www.newsrx.com/newsletters/Health-Business-Week/2006-10-27/102320063331046HBW.html DMZK7N8 DI DMZK7N8 DMZK7N8 DN Keratinocyte growth factor DMZK7N8 MI TTFY134 DMZK7N8 MN Keratinocyte growth factor (FGF7) DMZK7N8 MT DTT DMZK7N8 MA Modulator DMZK7N8 RN Keratinocyte growth factor.Cell Biol Int.1995 May;19(5):399-411. DMZK7N8 RU https://www.ncbi.nlm.nih.gov/pubmed/7640656 DMQ6DLZ DI DMQ6DLZ DMQ6DLZ DN KF-17837 DMQ6DLZ MI TTK25J1 DMQ6DLZ MN Adenosine A1 receptor (ADORA1) DMQ6DLZ MT DTT DMQ6DLZ MA Inhibitor DMQ6DLZ RN 2-Alkynyl-8-aryl-9-methyladenines as novel adenosine receptor antagonists: their synthesis and structure-activity relationships toward hepatic gluc... J Med Chem. 2001 Jan 18;44(2):170-9. DMQ6DLZ RU https://pubmed.ncbi.nlm.nih.gov/11170626 DMQ6DLZ DI DMQ6DLZ DMQ6DLZ DN KF-17837 DMQ6DLZ MI TTM2AOE DMQ6DLZ MN Adenosine A2a receptor (ADORA2A) DMQ6DLZ MT DTT DMQ6DLZ MA Inhibitor DMQ6DLZ RN Photoisomerization of a potent and selective adenosine A2 antagonist, (E)-1,3-Dipropyl-8-(3,4-dimethoxystyryl)-7-methylxanthine. J Med Chem. 1993 Nov 12;36(23):3731-3. DMQ6DLZ RU https://pubmed.ncbi.nlm.nih.gov/8246243 DMQ6DLZ DI DMQ6DLZ DMQ6DLZ DN KF-17837 DMQ6DLZ MI TTNE7KG DMQ6DLZ MN Adenosine A2b receptor (ADORA2B) DMQ6DLZ MT DTT DMQ6DLZ MA Inhibitor DMQ6DLZ RN Photoisomerization of a potent and selective adenosine A2 antagonist, (E)-1,3-Dipropyl-8-(3,4-dimethoxystyryl)-7-methylxanthine. J Med Chem. 1993 Nov 12;36(23):3731-3. DMQ6DLZ RU https://pubmed.ncbi.nlm.nih.gov/8246243 DMR14VE DI DMR14VE DMR14VE DN KH-901 DMR14VE MI TT6MP2Z DMR14VE MN GMCSFR-alpha (CSF2RA) DMR14VE MT DTT DMR14VE RN Effects of KH901, a tumor-specific oncolytic recombinant adenovirus, on antitumor and expressing GM-CSF in xenograft tumor models. Sichuan Da Xue Xue Bao Yi Xue Ban. 2007 Jun;38(3):386-90. DMR14VE RU https://pubmed.ncbi.nlm.nih.gov/17593813 DMLSUQ8 DI DMLSUQ8 DMLSUQ8 DN KHK2455 DMLSUQ8 MI TTZJYKH DMLSUQ8 MN Indoleamine 2,3-dioxygenase 1 (IDO1) DMLSUQ8 MT DTT DMLSUQ8 MA Inhibitor DMLSUQ8 RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMLSUQ8 RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DMR7EF6 DI DMR7EF6 DMR7EF6 DN KHK-2866 DMR7EF6 MI TT15SL0 DMR7EF6 MN Proheparin-binding EGF-like growth factor (HBEGF) DMR7EF6 MT DTT DMR7EF6 RN ClinicalTrials.gov (NCT01279291) Study of Anti-HB-EGF Antibody KHK2866 in Subjects With Advanced Solid Tumors and Ovarian Cancer. U.S. National Institutes of Health. DMR7EF6 RU https://clinicaltrials.gov/ct2/show/NCT01279291 DMIAVBL DI DMIAVBL DMIAVBL DN Ki23819 DMIAVBL MI TTGJCWZ DMIAVBL MN Fms-like tyrosine kinase 3 (FLT-3) DMIAVBL MT DTT DMIAVBL MA Inhibitor DMIAVBL RN Identification of Ki23819, a highly potent inhibitor of kinase activity of mutant FLT3 receptor tyrosine kinase. Leukemia. 2005 Jun;19(6):930-5. DMIAVBL RU https://pubmed.ncbi.nlm.nih.gov/15815726 DMUB3H9 DI DMUB3H9 DMUB3H9 DN KITE-439 DMUB3H9 MI TT3CPZW DMUB3H9 MN Human papillomavirus protein E7 (HPV E7) DMUB3H9 MT DTT DMUB3H9 MA Inhibitor DMUB3H9 RN ClinicalTrials.gov (NCT03912831) Safety and Efficacy of KITE-439 in HLA-A*02:01+ Adults With Relapsed/Refractory HPV16+ Cancers. U.S. National Institutes of Health. DMUB3H9 RU https://clinicaltrials.gov/ct2/show/NCT03912831 DMXR6HI DI DMXR6HI DMXR6HI DN KITE-585 DMXR6HI MI TTZ3P4W DMXR6HI MN B-cell maturation protein (TNFRSF17) DMXR6HI MT DTT DMXR6HI MA CAR-T-Cell-Therapy DMXR6HI RN ClinicalTrials.gov (NCT03318861) A Study Evaluating the Safety and Efficacy of KITE-585 in Subjects With Relapsed/Refractory Multiple Myeloma DMXR6HI RU https://clinicaltrials.gov/ct2/show/NCT03318861 DMBSI6Y DI DMBSI6Y DMBSI6Y DN KITE-718 DMBSI6Y MI TTWSKHD DMBSI6Y MN Melanoma-associated antigen 3 (MAGEA3) DMBSI6Y MT DTT DMBSI6Y RN ClinicalTrials.gov (NCT03139370) Safety and Efficacy of MAGE-A3/A6 T Cell Receptor Engineered T Cells (KITE-718) in HLA-DPB1*04:01 Positive Adults With Advanced Cancers. U.S. National Institutes of Health. DMBSI6Y RU https://clinicaltrials.gov/ct2/show/NCT03139370 DMBSI6Y DI DMBSI6Y DMBSI6Y DN KITE-718 DMBSI6Y MI TTJIWMO DMBSI6Y MN Melanoma-associated antigen 6 (MAGEA6) DMBSI6Y MT DTT DMBSI6Y RN ClinicalTrials.gov (NCT03139370) Safety and Efficacy of MAGE-A3/A6 T Cell Receptor Engineered T Cells (KITE-718) in HLA-DPB1*04:01 Positive Adults With Advanced Cancers. U.S. National Institutes of Health. DMBSI6Y RU https://clinicaltrials.gov/ct2/show/NCT03139370 DME8DUV DI DME8DUV DME8DUV DN KM-023 DME8DUV MI TT84ETX DME8DUV MN Human immunodeficiency virus Reverse transcriptase (HIV RT) DME8DUV MT DTT DME8DUV MA Inhibitor DME8DUV RN Pharmacokinetics and tolerability of the new second-generation nonnucleoside reverse- transcriptase inhibitor KM-023 in healthy subjects. Drug Des Devel Ther. 2014 Sep 26;8:1613-9. DME8DUV RU https://pubmed.ncbi.nlm.nih.gov/25302016 DMRAWGC DI DMRAWGC DMRAWGC DN KM-819 DMRAWGC MI TTSKL3G DMRAWGC MN FAS-associated factor 1 (FAF1) DMRAWGC MT DTT DMRAWGC MA Inhibitor DMRAWGC RN A first-in-human study to investigate the safety, tolerability, pharmacokinetics, and pharmacodynamics of KM-819 (FAS-associated factor 1 inhibitor), a drug for Parkinson's disease, in healthy volunteers. Drug Des Devel Ther. 2019 Mar 29;13:1011-1022. DMRAWGC RU https://pubmed.ncbi.nlm.nih.gov/30992659 DM1D2O0 DI DM1D2O0 DM1D2O0 DN KML-001 DM1D2O0 MI TTUJFD0 DM1D2O0 MN Telomerase reverse transcriptase (TERT) DM1D2O0 MT DTT DM1D2O0 MA Inhibitor DM1D2O0 RN National Cancer Institute Drug Dictionary (drug id 672554). DM1D2O0 RU http://www.cancer.gov/publications/dictionaries/cancer-drug?cdrid=672554 DMZMSBI DI DMZMSBI DMZMSBI DN KO-947 DMZMSBI MI TTKPV6O DMZMSBI MN Ephrin type-B receptor 2 (EPHB2) DMZMSBI MT DTT DMZMSBI MA Inhibitor DMZMSBI RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMZMSBI RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DM4953W DI DM4953W DM4953W DN KOS-2187 DM4953W MI TT953CX DM4953W MN Motilin receptor (MLNR) DM4953W MT DTT DM4953W MA Agonist DM4953W RN Kosan Announces Selection of KOS-2187 As Motilide Clinical Candidate at World Congress of Gastroenterology Meeting. Kosan. 2006. DM4953W RU http://www.redorbit.com/news/health/237602/kosan_announces_selection_of_kos2187_as_motilide_clinical_candidate_at/ DMSKI8W DI DMSKI8W DMSKI8W DN KPG-121 DMSKI8W MI TTEZQ39 DMSKI8W MN Cerebron E3 ubiquitin ligase complex (CRL4-CRBN E3 ubiquitin ligase) DMSKI8W MT DTT DMSKI8W MA Modulator DMSKI8W RN Clinical pipeline report, company report or official report of Kangpu Biopharmaceuticals. DMSKI8W RU https://www.kangpugroup.com/research_development/pipeline.html DM1O2X6 DI DM1O2X6 DM1O2X6 DN KPG-818 DM1O2X6 MI TTEZQ39 DM1O2X6 MN Cerebron E3 ubiquitin ligase complex (CRL4-CRBN E3 ubiquitin ligase) DM1O2X6 MT DTT DM1O2X6 MA Modulator DM1O2X6 RN Clinical pipeline report, company report or official report of Kangpu Biopharmaceuticals. DM1O2X6 RU https://www.kangpugroup.com/research_development/pipeline.html DMYBHER DI DMYBHER DMYBHER DN KPL-716 DMYBHER MI TT1RJXK DMYBHER MN Interleukin-31 (IL31) DMYBHER MT DTT DMYBHER MA Inhibitor DMYBHER RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMYBHER RU http://phrma-docs.phrma.org/files/dmfile/MID_Skin_Diseases_2018_9_FINAL.pdf DM9JXMD DI DM9JXMD DM9JXMD DN KPT-9274 DM9JXMD MI TT7Y3BZ DM9JXMD MN PAK-4 protein kinase (PAK4) DM9JXMD MT DTT DM9JXMD MA Inhibitor DM9JXMD RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DM9JXMD RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DMK0BTN DI DMK0BTN DMK0BTN DN KQ-791 DMK0BTN MI TTMS7KP DMK0BTN MN Protein-tyrosine phosphatase 1B (PTP1B) DMK0BTN MT DTT DMK0BTN MA Antagonist DMK0BTN RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMK0BTN RU http://phrma-docs.phrma.org/files/dmfile/mid-diabetes-drug-list.pdf DMODGJU DI DMODGJU DMODGJU DN KRN633 DMODGJU MI TTUTJGQ DMODGJU MN Vascular endothelial growth factor receptor 2 (KDR) DMODGJU MT DTT DMODGJU MA Inhibitor DMODGJU RN A comparison of physicochemical property profiles of marketed oral drugs and orally bioavailable anti-cancer protein kinase inhibitors in clinical development. Curr Top Med Chem. 2007;7(14):1408-22. DMODGJU RU https://pubmed.ncbi.nlm.nih.gov/17692029 DM8FQPX DI DM8FQPX DM8FQPX DN KTN3379 DM8FQPX MI TTDC8N2 DM8FQPX MN Erbb3 tyrosine kinase receptor (Erbb-3) DM8FQPX MT DTT DM8FQPX RN A critical role for HER3 in HER2-amplified and non-amplified breast cancers: function of a kinase-dead RTK. Am J Transl Res. 2015; 7(4): 733-750. DM8FQPX RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4455348/ DMTFWLE DI DMTFWLE DMTFWLE DN KUC-7483 DMTFWLE MI TTMXGCW DMTFWLE MN Adrenergic receptor beta-3 (ADRB3) DMTFWLE MT DTT DMTFWLE MA Agonist DMTFWLE RN Effects of ritobegron (KUC-7483), a novel selective beta3-adrenoceptor agonist, on bladder function in cynomolgus monkey. J Pharmacol Exp Ther. 2012 Jul;342(1):163-8. DMTFWLE RU https://pubmed.ncbi.nlm.nih.gov/22511202 DMKFVX5 DI DMKFVX5 DMKFVX5 DN KUL-7211 DMKFVX5 MI TT2CJVK DMKFVX5 MN Adrenergic receptor beta-2 (ADRB2) DMKFVX5 MT DTT DMKFVX5 MA Modulator DMKFVX5 RN The potency of KUL-7211, a selective ureteral relaxant, in isolated canine ureter: comparison with various spasmolytics.Urol Res.2005 Dec;33(6):409-14. DMKFVX5 RU https://www.ncbi.nlm.nih.gov/pubmed/16133579 DMKFVX5 DI DMKFVX5 DMKFVX5 DN KUL-7211 DMKFVX5 MI TTMXGCW DMKFVX5 MN Adrenergic receptor beta-3 (ADRB3) DMKFVX5 MT DTT DMKFVX5 MA Modulator DMKFVX5 RN The potency of KUL-7211, a selective ureteral relaxant, in isolated canine ureter: comparison with various spasmolytics.Urol Res.2005 Dec;33(6):409-14. DMKFVX5 RU https://www.ncbi.nlm.nih.gov/pubmed/16133579 DMKMN5R DI DMKMN5R DMKMN5R DN KUR-501 DMKMN5R MI TT80ARU DMKMN5R MN Ganglioside GD2 (GD2) DMKMN5R MT DTT DMKMN5R RN Clinical pipeline report, company report or official report of Kuur Therapeutics. DMKMN5R RU https://kuurtx.com/product-overview/ DMS9LVC DI DMS9LVC DMS9LVC DN KUR-502 DMS9LVC MI TTW640A DMS9LVC MN B-lymphocyte surface antigen B4 (CD19) DMS9LVC MT DTT DMS9LVC RN Clinical pipeline report, company report or official report of Kuur Therapeutics. DMS9LVC RU https://kuurtx.com/product-overview/ DMFO7RP DI DMFO7RP DMFO7RP DN KW-2449 DMFO7RP MI TTRLW2X DMFO7RP MN Fibroblast growth factor receptor 1 (FGFR1) DMFO7RP MT DTT DMFO7RP RN KW-2449, a novel multikinase inhibitor, suppresses the growth of leukemia cells with FLT3 mutations or T315I-mutated BCR/ABL translocation. Blood. 2009 Aug 20;114(8):1607-17. DMFO7RP RU https://pubmed.ncbi.nlm.nih.gov/19541823 DMFO7RP DI DMFO7RP DMFO7RP DN KW-2449 DMFO7RP MI TTGJCWZ DMFO7RP MN Fms-like tyrosine kinase 3 (FLT-3) DMFO7RP MT DTT DMFO7RP RN KW-2449, a novel multikinase inhibitor, suppresses the growth of leukemia cells with FLT3 mutations or T315I-mutated BCR/ABL translocation. Blood. 2009 Aug 20;114(8):1607-17. DMFO7RP RU https://pubmed.ncbi.nlm.nih.gov/19541823 DMFO7RP DI DMFO7RP DMFO7RP DN KW-2449 DMFO7RP MI TT3PJMV DMFO7RP MN Tyrosine-protein kinase ABL1 (ABL) DMFO7RP MT DTT DMFO7RP RN KW-2449, a novel multikinase inhibitor, suppresses the growth of leukemia cells with FLT3 mutations or T315I-mutated BCR/ABL translocation. Blood. 2009 Aug 20;114(8):1607-17. DMFO7RP RU https://pubmed.ncbi.nlm.nih.gov/19541823 DMALK7F DI DMALK7F DMALK7F DN KW-5092 DMALK7F MI TT1RS9F DMALK7F MN Acetylcholinesterase (AChE) DMALK7F MT DTT DMALK7F MA Inhibitor DMALK7F RN Oral administration of KW-5092, a novel gastroprokinetic agent with acetylcholinesterase inhibitory and acetylcholine release enhancing activities, causes a dose-dependent increase in the blood acetylcholine content of beagle dogs. Neurosci Lett. 1997 Mar 28;225(1):25-8. DMALK7F RU https://pubmed.ncbi.nlm.nih.gov/9143009 DML4H05 DI DML4H05 DML4H05 DN KX2-361 DML4H05 MI TT6PKBN DML4H05 MN Proto-oncogene c-Src (SRC) DML4H05 MT DTT DML4H05 MA Inhibitor DML4H05 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2206). DML4H05 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2206 DMWSC5L DI DMWSC5L DMWSC5L DN L-778123 DMWSC5L MI TTXQKM3 DMWSC5L MN Farnesyl protein transferase (Ftase) DMWSC5L MT DTT DMWSC5L MA Modulator DMWSC5L RN Preclinical and clinical pharmacodynamic assessment of L-778,123, a dual inhibitor of farnesyl:protein transferase and geranylgeranyl:protein trans... Mol Cancer Ther. 2002 Jul;1(9):747-58. DMWSC5L RU https://www.ncbi.nlm.nih.gov/pubmed/12479371 DMWSC5L DI DMWSC5L DMWSC5L DN L-778123 DMWSC5L MI TTX20QP DMWSC5L MN Geranylgeranyl transferase I (GGTase-I) DMWSC5L MT DTT DMWSC5L MA Modulator DMWSC5L RN Preclinical and clinical pharmacodynamic assessment of L-778,123, a dual inhibitor of farnesyl:protein transferase and geranylgeranyl:protein trans... Mol Cancer Ther. 2002 Jul;1(9):747-58. DMWSC5L RU https://www.ncbi.nlm.nih.gov/pubmed/12479371 DMXKO1L DI DMXKO1L DMXKO1L DN L-796568 DMXKO1L MI TTR6W5O DMXKO1L MN Adrenergic receptor beta-1 (ADRB1) DMXKO1L MT DTT DMXKO1L MA Inhibitor DMXKO1L RN Heterocyclic acetamide and benzamide derivatives as potent and selective beta3-adrenergic receptor agonists with improved rodent pharmacokinetic pr... Bioorg Med Chem Lett. 2010 Mar 15;20(6):1895-9. DMXKO1L RU https://pubmed.ncbi.nlm.nih.gov/20181479 DMXKO1L DI DMXKO1L DMXKO1L DN L-796568 DMXKO1L MI TT2CJVK DMXKO1L MN Adrenergic receptor beta-2 (ADRB2) DMXKO1L MT DTT DMXKO1L MA Inhibitor DMXKO1L RN Heterocyclic acetamide and benzamide derivatives as potent and selective beta3-adrenergic receptor agonists with improved rodent pharmacokinetic pr... Bioorg Med Chem Lett. 2010 Mar 15;20(6):1895-9. DMXKO1L RU https://pubmed.ncbi.nlm.nih.gov/20181479 DM8ANIM DI DM8ANIM DM8ANIM DN Lactermin DM8ANIM MI TTDB5IS DM8ANIM MN Receptor unspecific (Rec) DM8ANIM MT DTT DM8ANIM MA Modulator DM8ANIM RN Mammalian lactoferrin receptors: structure and function. Cell Mol Life Sci. 2005 Nov;62(22):2560-75. DM8ANIM RU https://pubmed.ncbi.nlm.nih.gov/16261254 DMO4GPK DI DMO4GPK DMO4GPK DN Lactose DMO4GPK MI DEQB4LT DMO4GPK MN Beta-galactosidase (bgaB) DMO4GPK MT DME DMO4GPK MA Metabolism DMO4GPK RN Identification and characterization of a novel beta-galactosidase from Victivallis vadensis ATCC BAA-548, an anaerobic fecal bacterium. J Microbiol. 2012 Dec;50(6):1034-40. DMO4GPK RU https://pubmed.ncbi.nlm.nih.gov/23274992 DMO4GPK DI DMO4GPK DMO4GPK DN Lactose DMO4GPK MI DEGLW18 DMO4GPK MN Cellobiose 2-epimerase (CE) DMO4GPK MT DME DMO4GPK MA Metabolism DMO4GPK RN Cloning and sequencing of the gene for cellobiose 2-epimerase from a ruminal strain of Eubacterium cellulosolvens. FEMS Microbiol Lett. 2008 Oct;287(1):34-40. DMO4GPK RU https://pubmed.ncbi.nlm.nih.gov/18710396 DMO4GPK DI DMO4GPK DMO4GPK DN Lactose DMO4GPK MI DENTGJO DMO4GPK MN Cellobiose 2-epimerase (CE) DMO4GPK MT DME DMO4GPK MA Metabolism DMO4GPK RN Cloning and sequencing of the gene for cellobiose 2-epimerase from a ruminal strain of Eubacterium cellulosolvens. FEMS Microbiol Lett. 2008 Oct;287(1):34-40. DMO4GPK RU https://pubmed.ncbi.nlm.nih.gov/18710396 DMO4GPK DI DMO4GPK DMO4GPK DN Lactose DMO4GPK MI DE4XLDR DMO4GPK MN Cellobiose 2-epimerase (CE) DMO4GPK MT DME DMO4GPK MA Metabolism DMO4GPK RN Cloning and sequencing of the gene for cellobiose 2-epimerase from a ruminal strain of Eubacterium cellulosolvens. FEMS Microbiol Lett. 2008 Oct;287(1):34-40. DMO4GPK RU https://pubmed.ncbi.nlm.nih.gov/18710396 DMO4GPK DI DMO4GPK DMO4GPK DN Lactose DMO4GPK MI DEGBVKJ DMO4GPK MN Cellobiose 2-epimerase (CE) DMO4GPK MT DME DMO4GPK MA Metabolism DMO4GPK RN Cloning and sequencing of the gene for cellobiose 2-epimerase from a ruminal strain of Eubacterium cellulosolvens. FEMS Microbiol Lett. 2008 Oct;287(1):34-40. DMO4GPK RU https://pubmed.ncbi.nlm.nih.gov/18710396 DMO4GPK DI DMO4GPK DMO4GPK DN Lactose DMO4GPK MI DEDY9F6 DMO4GPK MN Cellobiose 2-epimerase (CE) DMO4GPK MT DME DMO4GPK MA Metabolism DMO4GPK RN Cloning and sequencing of the gene for cellobiose 2-epimerase from a ruminal strain of Eubacterium cellulosolvens. FEMS Microbiol Lett. 2008 Oct;287(1):34-40. DMO4GPK RU https://pubmed.ncbi.nlm.nih.gov/18710396 DMC0VJF DI DMC0VJF DMC0VJF DN Laevo-Bambuterol DMC0VJF MI TTMXGCW DMC0VJF MN Adrenergic receptor beta-3 (ADRB3) DMC0VJF MT DTT DMC0VJF MA Modulator DMC0VJF RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 29). DMC0VJF RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=29 DM7JNHU DI DM7JNHU DM7JNHU DN LAM-001 DM7JNHU MI TTCJG29 DM7JNHU MN Serine/threonine-protein kinase mTOR (mTOR) DM7JNHU MT DTT DM7JNHU MA Inhibitor DM7JNHU RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DM7JNHU RU http://phrma-docs.phrma.org/sites/default/files/pdf/medicines-in-development-drug-list-rare-diseases.pdf DMQHWMJ DI DMQHWMJ DMQHWMJ DN LAM-003 DMQHWMJ MI TTO7FVG DMQHWMJ MN Heat shock protein 90 (HSP90) DMQHWMJ MT DTT DMQHWMJ MA Inhibitor DMQHWMJ RN LAM-003, a new drug for treatment of tyrosine kinase inhibitor-resistant FLT3-ITD-positive AML. Blood Adv. 2019 Nov 26;3(22):3661-3673. DMQHWMJ RU https://pubmed.ncbi.nlm.nih.gov/31751472 DM1C4UM DI DM1C4UM DM1C4UM DN LAMB3-transduced autologous epidermal stem cells DM1C4UM MI TT2WOUQ DM1C4UM MN Laminin beta-3 chain (LAMB3) DM1C4UM MT DTT DM1C4UM MA Modulator DM1C4UM RN Correction of junctional epidermolysis bullosa by transplantation of genetically modified epidermal stem cells. Nat Med. 2006 Dec;12(12):1397-402. DM1C4UM RU https://pubmed.ncbi.nlm.nih.gov/17115047 DMV80DP DI DMV80DP DMV80DP DN LAS-186323 DMV80DP MI TTLVP78 DMV80DP MN Dihydroorotate dehydrogenase (DHODH) DMV80DP MT DTT DMV80DP MA Inhibitor DMV80DP RN Clinical pipeline report, company report or official report of Aslanpharma. DMV80DP RU http://www.aslanpharma.com/download/Press%20Release%20-%20Almirall-ASLAN%20Licensing.pdf DM4YA0D DI DM4YA0D DM4YA0D DN LBR-101 DM4YA0D MI TTY6O0Q DM4YA0D MN Calcitonin gene-related peptide receptor (CGRPR) DM4YA0D MT DTT DM4YA0D RN Safety and tolerability of LBR-101, a humanized monoclonal antibody that blocks the binding of CGRP to its receptor: Results of the Phase 1 program. Cephalalgia. 2013 Dec 23;34(7):483-492. DM4YA0D RU https://pubmed.ncbi.nlm.nih.gov/24366980 DMJEACT DI DMJEACT DMJEACT DN LC-1 DMJEACT MI TTSXVID DMJEACT MN Nuclear factor NF-kappa-B (NFKB) DMJEACT MT DTT DMJEACT MA Inhibitor DMJEACT RN A water soluble parthenolide analogue suppresses in vivo tumor growth of two tobacco associated cancers, lung and bladder cancer, by targeting NF- B and generating reactive oxygen species. Int J Cancer. 2011 May 15; 128(10): 2481-2494. DMJEACT RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2982935/ DMHT3CB DI DMHT3CB DMHT3CB DN LC-350189 DMHT3CB MI TT7RJY8 DMHT3CB MN Xanthine dehydrogenase/oxidase (XDH) DMHT3CB MT DTT DMHT3CB MA Inhibitor DMHT3CB RN Pharmacokinetics, pharmacodynamics, and tolerability of LC350189, a novel xanthine oxidase inhibitor, in healthy subjects. Drug Des Devel Ther. 2015 Aug 31;9:5033-49. DMHT3CB RU https://pubmed.ncbi.nlm.nih.gov/26357467 DMEY2LK DI DMEY2LK DMEY2LK DN LCAR-B4822M CAR-T Cell DMEY2LK MI TTZ3P4W DMEY2LK MN B-cell maturation protein (TNFRSF17) DMEY2LK MT DTT DMEY2LK MA CAR-T-Cell-Therapy DMEY2LK RN ClinicalTrials.gov (NCT03674463) LCAR-B4822M-02 Cells in Treating Relapsed/Refractory (R/R) Multiple Myeloma DMEY2LK RU https://clinicaltrials.gov/ct2/show/NCT03674463 DM9LYXQ DI DM9LYXQ DM9LYXQ DN Leflunomide DM9LYXQ MI TT3UY29 DM9LYXQ MN HUMAN dihydroorotate dehydrogenase (DHODH) DM9LYXQ MT DTT DM9LYXQ MA Inhibitor DM9LYXQ RN On dihydroorotate dehydrogenases and their inhibitors and uses. J Med Chem. 2013 Apr 25;56(8):3148-67. doi: 10.1021/jm301848w. DM9LYXQ RU https://pubmed.ncbi.nlm.nih.gov/23452331 DMKZVLH DI DMKZVLH DMKZVLH DN Lefradafiban DMKZVLH MI TT38RM1 DMKZVLH MN Glycoprotein IIb/IIIa receptor (GPIIb/IIIa) DMKZVLH MT DTT DMKZVLH MA Modulator DMKZVLH RN Pharmacodynamics and safety of lefradafiban, an oral platelet glycoprotein IIb/IIIa receptor antagonist, in patients with stable coronary artery disease undergoing elective angioplasty. Heart. 2001 Apr;85(4):444-50. DMKZVLH RU https://pubmed.ncbi.nlm.nih.gov/11250974 DM5INZP DI DM5INZP DM5INZP DN LEQ-506 DM5INZP MI TT8J1S3 DM5INZP MN Smoothened homolog (SMO) DM5INZP MT DTT DM5INZP MA Inhibitor DM5INZP RN Discovery of NVP-LEQ506, a second-generation inhibitor of smoothened. ChemMedChem. 2013 Aug;8(8):1261-5. DM5INZP RU https://pubmed.ncbi.nlm.nih.gov/23821351 DMNHPOT DI DMNHPOT DMNHPOT DN LErafAON DMNHPOT MI TTAN5W2 DMNHPOT MN Raf messenger RNA (Raf mRNA) DMNHPOT MT DTT DMNHPOT RN Combination with liposome-entrapped, ends-modified raf antisense oligonucleotide (LErafAON) improves the anti-tumor efficacies of cisplatin, epirubicin, mitoxantrone, docetaxel and gemcitabine. Anticancer Drugs. 2004 Mar;15(3):243-53. DMNHPOT RU https://pubmed.ncbi.nlm.nih.gov/15014358 DM2B0TJ DI DM2B0TJ DM2B0TJ DN Leukocyte interleukin DM2B0TJ MI TT9721Y DM2B0TJ MN Interleukin 2 receptor beta (IL2RB) DM2B0TJ MT DTT DM2B0TJ MA Modulator DM2B0TJ RN Leukocyte Interleukin, Inj. (LI) augmentation of natural killer cells and cytolytic T-lymphocytes. Immunopharmacol Immunotoxicol. 1995 May;17(2):247-64. DM2B0TJ RU https://pubmed.ncbi.nlm.nih.gov/7650289 DMI4O92 DI DMI4O92 DMI4O92 DN LFA-102 DMI4O92 MI TTBPXMA DMI4O92 MN Prolactin receptor (PRLR) DMI4O92 MT DTT DMI4O92 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1721). DMI4O92 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1721 DMAG6BV DI DMAG6BV DMAG6BV DN LGK974 DMAG6BV MI TTNFBTO DMAG6BV MN Protein-serine O-palmitoleoyltransferase porcupine (PORCN) DMAG6BV MT DTT DMAG6BV MA Inhibitor DMAG6BV RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMAG6BV RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DMYK52O DI DMYK52O DMYK52O DN LHC165 DMYK52O MI TTRJ1K4 DMYK52O MN Toll-like receptor 7 (TLR7) DMYK52O MT DTT DMYK52O MA Agonist DMYK52O RN Agonist and antagonist ligands of toll-like receptors 7 and 8: Ingenious tools for therapeutic purposes. Eur J Med Chem. 2020 May 1;193:112238. DMYK52O RU https://pubmed.ncbi.nlm.nih.gov/32203790 DMFNSHM DI DMFNSHM DMFNSHM DN LHF-535 DMFNSHM MI TTD2IK3 DMFNSHM MN Lassa virus Pre-glycoprotein polyprotein GP complex (LASV GPC) DMFNSHM MT DTT DMFNSHM MA Inhibitor DMFNSHM RN A potent Lassa virus antiviral targets an arenavirus virulence determinant. PLoS Pathog. 2018 Dec 21;14(12):e1007439. DMFNSHM RU https://pubmed.ncbi.nlm.nih.gov/30576397 DMJRALD DI DMJRALD DMJRALD DN LIPO-4 DMJRALD MI TTN2JFW DMJRALD MN T-cell surface glycoprotein CD4 (CD4) DMJRALD MT DTT DMJRALD RN Long-term CD4(+) and CD8(+) T-cell responses induced in HIV-uninfected volunteers following intradermal or intramuscular administration of an HIV-lipopeptide vaccine (ANRS VAC16). Vaccine. 2013 Sep 13;31(40):4406-15. DMJRALD RU https://pubmed.ncbi.nlm.nih.gov/23850610 DMJRALD DI DMJRALD DMJRALD DN LIPO-4 DMJRALD MI TTMHA6L DMJRALD MN T-cell surface glycoprotein CD8 (CD8) DMJRALD MT DTT DMJRALD RN Long-term CD4(+) and CD8(+) T-cell responses induced in HIV-uninfected volunteers following intradermal or intramuscular administration of an HIV-lipopeptide vaccine (ANRS VAC16). Vaccine. 2013 Sep 13;31(40):4406-15. DMJRALD RU https://pubmed.ncbi.nlm.nih.gov/23850610 DMESZQU DI DMESZQU DMESZQU DN Litenimod DMESZQU MI TTSHG0T DMESZQU MN Toll-like receptor 9 (TLR9) DMESZQU MT DTT DMESZQU MA Modulator DMESZQU RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1759). DMESZQU RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1759 DMR7LKC DI DMR7LKC DMR7LKC DN LM-CD45 DMR7LKC MI TTUS45N DMR7LKC MN Leukocyte common antigen (PTPRC) DMR7LKC MT DTT DMR7LKC RN Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800002932) DMR7LKC RU http://adisinsight.springer.com/drugs/800002932 DMU901D DI DMU901D DMU901D DN L-MDAM DMU901D MI TTYZVDJ DMU901D MN Dihydrofolate reductase (DHFR) DMU901D MT DTT DMU901D MA Inhibitor DMU901D RN Polyglutamylation of the dihydrofolate reductase inhibitor gamma-methylene-10-deazaaminopterin is not essential for antitumor activity. Clin Cancer Res. 1996 Apr;2(4):707-12. DMU901D RU https://pubmed.ncbi.nlm.nih.gov/9816221 DMZU2G1 DI DMZU2G1 DMZU2G1 DN LMP-1/LMP-2 CTLs DMZU2G1 MI TT0BI4Q DMZU2G1 MN Epstein-Barr virus Latent membrane protein 1 (EBV LMP1) DMZU2G1 MT DTT DMZU2G1 MA Modulator DMZU2G1 RN In vivo expansion of LMP 1- and 2-specific T-cells in a patient who received donor-derived EBV-specific T-cells after allogeneic stem cell transplantation. Leuk Lymphoma. 2006 May;47(5):837-42. DMZU2G1 RU https://pubmed.ncbi.nlm.nih.gov/16753867 DMZU2G1 DI DMZU2G1 DMZU2G1 DN LMP-1/LMP-2 CTLs DMZU2G1 MI TTBK351 DMZU2G1 MN Epstein-Barr virus Latent membrane protein 2 (EBV LMP2) DMZU2G1 MT DTT DMZU2G1 MA Modulator DMZU2G1 RN In vivo expansion of LMP 1- and 2-specific T-cells in a patient who received donor-derived EBV-specific T-cells after allogeneic stem cell transplantation. Leuk Lymphoma. 2006 May;47(5):837-42. DMZU2G1 RU https://pubmed.ncbi.nlm.nih.gov/16753867 DM4FW2E DI DM4FW2E DM4FW2E DN LMP400 DM4FW2E MI TTGTQHC DM4FW2E MN DNA topoisomerase I (TOP1) DM4FW2E MT DTT DM4FW2E MA Inhibitor DM4FW2E RN Targeting Topoisomerase I in the Era of Precision Medicine. Clin Cancer Res. 2019 Nov 15;25(22):6581-6589. DM4FW2E RU https://pubmed.ncbi.nlm.nih.gov/31227499 DMUCQYW DI DMUCQYW DMUCQYW DN LMP744 DMUCQYW MI TTGTQHC DMUCQYW MN DNA topoisomerase I (TOP1) DMUCQYW MT DTT DMUCQYW MA Inhibitor DMUCQYW RN Targeting Topoisomerase I in the Era of Precision Medicine. Clin Cancer Res. 2019 Nov 15;25(22):6581-6589. DMUCQYW RU https://pubmed.ncbi.nlm.nih.gov/31227499 DM9OA35 DI DM9OA35 DM9OA35 DN Long-acting erythropoietin conjugate DM9OA35 MI TTQG4NR DM9OA35 MN Erythropoietin (EPO) DM9OA35 MT DTT DM9OA35 MA Modulator DM9OA35 RN Company report (Pharmexcil) DM9OA35 RU http://www.pharmexcil.com/v1/docs/KoreanCompanies/hanmi.pdf DMCKE90 DI DMCKE90 DMCKE90 DN Lopinavir + ritonavir + interferon apha + traditional chinese medicines granules DMCKE90 MI TT1D53B DMCKE90 MN COVID-19 3C-like protease (3CLpro) DMCKE90 MT DTT DMCKE90 MA Inhibitor DMCKE90 RN Coronavirus puts drug repurposing on the fast track. Nat Biotechnol. 2020 Apr;38(4):379-381. DMCKE90 RU https://pubmed.ncbi.nlm.nih.gov/32205870 DMDLTCU DI DMDLTCU DMDLTCU DN Lotilibcin DMDLTCU MI TTXT4D5 DMDLTCU MN Bacterial Cell membrane (Bact CM) DMDLTCU MT DTT DMDLTCU MA Modulator DMDLTCU RN Bioactive natural products from Lysobacter. Nat Prod Rep. 2012 November 8; 29(11): 1277-1287. DMDLTCU RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3468324/ DMDXFBJ DI DMDXFBJ DMDXFBJ DN LOXO-195 DMDXFBJ MI TTTDVOJ DMDXFBJ MN Tropomyosin-related kinase A (TrkA) DMDXFBJ MT DTT DMDXFBJ MA Inhibitor DMDXFBJ RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMDXFBJ RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DMYIXQZ DI DMYIXQZ DMYIXQZ DN LP-108 DMYIXQZ MI TTJGNVC DMYIXQZ MN Apoptosis regulator Bcl-2 (BCL-2) DMYIXQZ MT DTT DMYIXQZ RN National Cancer Institute Drug Dictionary (drug name LP-108). DMYIXQZ RU https://www.cancer.gov/publications/dictionaries/cancer-drug/def/bcl-2-inhibitor-lp-108 DM8VBQJ DI DM8VBQJ DM8VBQJ DN LS-69767 DM8VBQJ MI DE0JX6R DM8VBQJ MN Beta-galactosidase (bgaB) DM8VBQJ MT DME DM8VBQJ MA Metabolism DM8VBQJ RN In vitro fermentation of fructooligosaccharides with human gut bacteria. Food Funct. 2015 Mar;6(3):947-54. DM8VBQJ RU https://pubmed.ncbi.nlm.nih.gov/25653214 DM8VBQJ DI DM8VBQJ DM8VBQJ DN LS-69767 DM8VBQJ MI DE8J31V DM8VBQJ MN Beta-galactosidase (bgaB) DM8VBQJ MT DME DM8VBQJ MA Metabolism DM8VBQJ RN In vitro fermentation of fructooligosaccharides with human gut bacteria. Food Funct. 2015 Mar;6(3):947-54. DM8VBQJ RU https://pubmed.ncbi.nlm.nih.gov/25653214 DM8VBQJ DI DM8VBQJ DM8VBQJ DN LS-69767 DM8VBQJ MI DEIEY19 DM8VBQJ MN Beta-galactosidase (bgaB) DM8VBQJ MT DME DM8VBQJ MA Metabolism DM8VBQJ RN In vitro fermentation of fructooligosaccharides with human gut bacteria. Food Funct. 2015 Mar;6(3):947-54. DM8VBQJ RU https://pubmed.ncbi.nlm.nih.gov/25653214 DM8VBQJ DI DM8VBQJ DM8VBQJ DN LS-69767 DM8VBQJ MI DEH2VKT DM8VBQJ MN Glycoside hydrolase (cscA) DM8VBQJ MT DME DM8VBQJ MA Metabolism DM8VBQJ RN In vitro fermentation of fructooligosaccharides with human gut bacteria. Food Funct. 2015 Mar;6(3):947-54. DM8VBQJ RU https://pubmed.ncbi.nlm.nih.gov/25653214 DM8VBQJ DI DM8VBQJ DM8VBQJ DN LS-69767 DM8VBQJ MI DEWNRL1 DM8VBQJ MN Glycosyl hydrolase (glyH) DM8VBQJ MT DME DM8VBQJ MA Metabolism DM8VBQJ RN In vitro fermentation of fructooligosaccharides with human gut bacteria. Food Funct. 2015 Mar;6(3):947-54. DM8VBQJ RU https://pubmed.ncbi.nlm.nih.gov/25653214 DM8VBQJ DI DM8VBQJ DM8VBQJ DN LS-69767 DM8VBQJ MI DEDZECR DM8VBQJ MN Glycosyl hydrolase (glyH) DM8VBQJ MT DME DM8VBQJ MA Metabolism DM8VBQJ RN In vitro fermentation of fructooligosaccharides with human gut bacteria. Food Funct. 2015 Mar;6(3):947-54. DM8VBQJ RU https://pubmed.ncbi.nlm.nih.gov/25653214 DM8VBQJ DI DM8VBQJ DM8VBQJ DN LS-69767 DM8VBQJ MI DEPDE7J DM8VBQJ MN Glycosyl hydrolase (glyH) DM8VBQJ MT DME DM8VBQJ MA Metabolism DM8VBQJ RN In vitro fermentation of fructooligosaccharides with human gut bacteria. Food Funct. 2015 Mar;6(3):947-54. DM8VBQJ RU https://pubmed.ncbi.nlm.nih.gov/25653214 DM94E6W DI DM94E6W DM94E6W DN LTT462 DM94E6W MI TTVOE6D DM94E6W MN Mitogen-activated protein kinase (MAPK) DM94E6W MT DTT DM94E6W MA Inhibitor DM94E6W RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DM94E6W RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DMQ0K95 DI DMQ0K95 DMQ0K95 DN Lu-02-750 DMQ0K95 MI TTEX248 DMQ0K95 MN Dopamine D2 receptor (D2R) DMQ0K95 MT DTT DMQ0K95 MA Agonist DMQ0K95 RN Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800031195) DMQ0K95 RU http://adisinsight.springer.com/drugs/800031195 DMP9UO0 DI DMP9UO0 DMP9UO0 DN Lu-AE04621 DMP9UO0 MI TTEX248 DMP9UO0 MN Dopamine D2 receptor (D2R) DMP9UO0 MT DTT DMP9UO0 MA Modulator DMP9UO0 RN Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800031909) DMP9UO0 RU http://adisinsight.springer.com/drugs/800031909 DMQI970 DI DMQI970 DMQI970 DN Lumoxiti DMQI970 MI TTM6QSK DMQI970 MN B-cell receptor CD22 (CD22) DMQI970 MT DTT DMQI970 MA Inhibitor DMQI970 RN Clinical pipeline report, company report or official report of Innate Pharma. DMQI970 RU https://www.innate-pharma.com/fr/produits/lumoxiti DMPQE2S DI DMPQE2S DMPQE2S DN LVGN6051 DMPQE2S MI TTPW9LJ DMPQE2S MN Co-stimulatory molecule 4-1BB (CD137) DMPQE2S MT DTT DMPQE2S MA Activator DMPQE2S RN Optimization of 4-1BB antibody for cancer immunotherapy by balancing agonistic strength with FcR affinity. Nat Commun. 2019 May 20;10(1):2141. DMPQE2S RU https://pubmed.ncbi.nlm.nih.gov/31105267 DM8ZS7T DI DM8ZS7T DM8ZS7T DN LX2761 DM8ZS7T MI TT2UE56 DM8ZS7T MN Sodium/glucose cotransporter 1 (SGLT1) DM8ZS7T MT DTT DM8ZS7T MA Inhibitor DM8ZS7T RN Clinical pipeline report, company report or official report of Lexicon Pharmaceuticals. DM8ZS7T RU https://www.lexpharma.com/pipeline/lx2761 DMO548K DI DMO548K DMO548K DN LX9211 DMO548K MI TT0Z32T DMO548K MN Adaptor-associated kinase 1 (AAK1) DMO548K MT DTT DMO548K MA Inhibitor DMO548K RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMO548K RU http://phrma-docs.phrma.org/files/dmfile/MID_Neurological-Disorders-Drug-List_2018.pdf DMQE9PS DI DMQE9PS DMQE9PS DN LXH254 DMQE9PS MI TTAN5W2 DMQE9PS MN Raf messenger RNA (Raf mRNA) DMQE9PS MT DTT DMQE9PS MA Inhibitor DMQE9PS RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMQE9PS RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DM3OP41 DI DM3OP41 DM3OP41 DN LXR 623 DM3OP41 MI TTM1EQF DM3OP41 MN Oxysterols receptor LXR (NR1H) DM3OP41 MT DTT DM3OP41 MA Modulator DM3OP41 RN Liver X receptors in lipid metabolism: opportunities for drug discovery. Nat Rev Drug Discov. 2014 Jun;13(6):433-44. DM3OP41 RU https://pubmed.ncbi.nlm.nih.gov/24833295 DMCBV20 DI DMCBV20 DMCBV20 DN LY-2334737 DMCBV20 MI TTUTN1I DMCBV20 MN Human Deoxyribonucleic acid (hDNA) DMCBV20 MT DTT DMCBV20 MA Modulator DMCBV20 RN Phase I study of oral gemcitabine prodrug (LY2334737) in Japanese patients with advanced solid tumors. Cancer Chemother Pharmacol. 2013 Jun;71(6):1645-55. DMCBV20 RU https://pubmed.ncbi.nlm.nih.gov/23616084 DMCBV20 DI DMCBV20 DMCBV20 DN LY-2334737 DMCBV20 MI TTBWDI0 DMCBV20 MN Ribonucleoside-diphosphate reductase M2 (RRM2) DMCBV20 MT DTT DMCBV20 MA Modulator DMCBV20 RN Phase I study of oral gemcitabine prodrug (LY2334737) in Japanese patients with advanced solid tumors. Cancer Chemother Pharmacol. 2013 Jun;71(6):1645-55. DMCBV20 RU https://pubmed.ncbi.nlm.nih.gov/23616084 DML8M3B DI DML8M3B DML8M3B DN LY-2584702 DML8M3B MI TT7M3PI DML8M3B MN Ribosomal protein S6 kinase (S6K) DML8M3B MT DTT DML8M3B MA Modulator DML8M3B RN A phase Ib trial of LY2584702 tosylate, a p70 S6 inhibitor, in combination with erlotinib or everolimus in patients with solid tumours.Eur J Cancer.2014 Mar;50(5):876-84. DML8M3B RU https://www.ncbi.nlm.nih.gov/pubmed/24456794 DM289Z4 DI DM289Z4 DM289Z4 DN LY2624587 DM289Z4 MI TTBID49 DM289Z4 MN C-X-C chemokine receptor type 4 (CXCR4) DM289Z4 MT DTT DM289Z4 MA Antagonist DM289Z4 RN Inhibition of CXCR4 by LY2624587, a Fully Humanized Anti-CXCR4 Antibody Induces Apoptosis of Hematologic Malignancies. PLoS One. 2016 Mar 8;11(3):e0150585. DM289Z4 RU https://pubmed.ncbi.nlm.nih.gov/26954567 DM93AJW DI DM93AJW DM93AJW DN LY2780301 DM93AJW MI TTAZ05C DM93AJW MN RAC-gamma serine/threonine-protein kinase (AKT3) DM93AJW MT DTT DM93AJW MA Modulator DM93AJW RN A first-in-human phase I trial of LY2780301, a dual p70 S6 kinase and Akt Inhibitor, in patients with advanced or metastatic cancer. Invest New Drugs. 2015 Jun;33(3):710-9. DM93AJW RU https://pubmed.ncbi.nlm.nih.gov/25902900 DM93AJW DI DM93AJW DM93AJW DN LY2780301 DM93AJW MI TT7M3PI DM93AJW MN Ribosomal protein S6 kinase (S6K) DM93AJW MT DTT DM93AJW MA Modulator DM93AJW RN A first-in-human phase I trial of LY2780301, a dual p70 S6 kinase and Akt Inhibitor, in patients with advanced or metastatic cancer. Invest New Drugs. 2015 Jun;33(3):710-9. DM93AJW RU https://pubmed.ncbi.nlm.nih.gov/25902900 DM9NYHT DI DM9NYHT DM9NYHT DN LY2787106 DM9NYHT MI TTPCG5T DM9NYHT MN Hepcidin (HAMP) DM9NYHT MT DTT DM9NYHT MA Inhibitor DM9NYHT RN A first-in-human phase 1 study of a hepcidin monoclonal antibody, LY2787106, in cancer-associated anemia. J Hematol Oncol. 2017 Mar 21;10(1):73. DM9NYHT RU https://www.ncbi.nlm.nih.gov/pubmed/28327200 DM8LGWR DI DM8LGWR DM8LGWR DN LY-2811376 DM8LGWR MI TT8JRS7 DM8LGWR MN Beta-secretase (BACE) DM8LGWR MT DTT DM8LGWR MA Inhibitor DM8LGWR RN Neurodegenerative disease: Inhibiting beta-secretase in humans. Nature Reviews Drug Discovery 11, 21 (January 2012). DM8LGWR RU http://www.nature.com/nrd/journal/v11/n1/full/nrd3645.html DM8LGWR DI DM8LGWR DM8LGWR DN LY-2811376 DM8LGWR MI DE4LYSA DM8LGWR MN Cytochrome P450 3A4 (CYP3A4) DM8LGWR MT DME DM8LGWR MA Metabolism DM8LGWR RN Robust central reduction of amyloid-beta in humans with an orally available, non-peptidic beta-secretase inhibitor. J Neurosci. 2011 Nov 16;31(46):16507-16. DM8LGWR RU https://www.ncbi.nlm.nih.gov/pubmed/?term=22090477 DM5EXJV DI DM5EXJV DM5EXJV DN LY-2881835 DM5EXJV MI TTB8FUC DM5EXJV MN Free fatty acid receptor 1 (GPR40) DM5EXJV MT DTT DM5EXJV MA Modulator DM5EXJV RN Treatment of Type 2 Diabetes by Free Fatty Acid Receptor Agonists. Front Endocrinol (Lausanne) 2014; 5: 137. DM5EXJV RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4147718/ DMGLTE2 DI DMGLTE2 DMGLTE2 DN LY2922470 DMGLTE2 MI TTB8FUC DMGLTE2 MN Free fatty acid receptor 1 (GPR40) DMGLTE2 MT DTT DMGLTE2 MA Agonist DMGLTE2 RN The Discovery, Preclinical, and Early Clinical Development of Potent and Selective GPR40 Agonists for the Treatment of Type 2 Diabetes Mellitus (LY2881835, LY2922083, and LY2922470). J Med Chem. 2016 Dec 22;59(24):10891-10916. DMGLTE2 RU https://pubmed.ncbi.nlm.nih.gov/27749056 DMY1AFS DI DMY1AFS DMY1AFS DN LY294002 DMY1AFS MI TTHBTOP DMY1AFS MN PI3-kinase gamma (PIK3CG) DMY1AFS MT DTT DMY1AFS MA Inhibitor DMY1AFS RN Clinical pipeline report, company report or official report of Genentech (2009). DMY1AFS RU http://www.gene.com/gene/pipeline/status/ DM16IX2 DI DM16IX2 DM16IX2 DN LY-2979165 DM16IX2 MI TTXJ47W DM16IX2 MN Metabotropic glutamate receptor 2 (mGluR2) DM16IX2 MT DTT DM16IX2 MA Modulator DM16IX2 RN Annual Reports in Medicinal Chemistry. Volume 47, 2012, Page(78). DM16IX2 RU https://books.google.com.hk/books?id=y7GH165YoOsC&pg=PA78&lpg=PA78&dq=Annual+Reports+in+Medicinal+Chemistry++LY-2979165&source=bl&ots=oPRAtBeGRL&sig=la4YgUxL9zkXRln2i4EVFFFVzUg&hl=zh-CN&sa=X&ved=0CB4Q6AEwAGoVChMIsbb8qP3FyAIVC1iOCh3bcgiX#v=onepage&q=Annual%20Reports%20in%20Medicinal%20Chemistry%20%20LY-2979165&f=false DM6PFCN DI DM6PFCN DM6PFCN DN LY3009120 DM6PFCN MI TTQ9K3Y DM6PFCN MN Serine/threonine-protein kinase Raf (RAF) DM6PFCN MT DTT DM6PFCN MA Modulator DM6PFCN RN Company report (eli lily) DM6PFCN RU http://www.lillyoncologypipeline.com/pan-raf-inhibitor.aspx DMJPCHK DI DMJPCHK DMJPCHK DN LY309887 DMJPCHK MI TTEXB9Z DMJPCHK MN Glycinamide ribonucleotide formyltransferase (GART) DMJPCHK MT DTT DMJPCHK MA Inhibitor DMJPCHK RN New antimetabolites in cancer chemotherapy and their clinical impact. Br J Cancer. 1998;78 Suppl 3:1-7. DMJPCHK RU https://pubmed.ncbi.nlm.nih.gov/9717984 DM5OP86 DI DM5OP86 DM5OP86 DN LY3127804 DM5OP86 MI TTKLQTJ DM5OP86 MN Angiopoietin-2 (ANGPT2) DM5OP86 MT DTT DM5OP86 RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DM5OP86 RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DM9RTXM DI DM9RTXM DM9RTXM DN LY3164530 DM9RTXM MI TTGKNB4 DM9RTXM MN Epidermal growth factor receptor (EGFR) DM9RTXM MT DTT DM9RTXM MA Modulator DM9RTXM RN Bispecific antibodies rise again. Nat Rev Drug Discov. 2014 Nov;13(11):799-801. DM9RTXM RU https://www.ncbi.nlm.nih.gov/pubmed/25359367 DM9RTXM DI DM9RTXM DM9RTXM DN LY3164530 DM9RTXM MI TTNDSF4 DM9RTXM MN Proto-oncogene c-Met (MET) DM9RTXM MT DTT DM9RTXM MA Modulator DM9RTXM RN Bispecific antibodies rise again. Nat Rev Drug Discov. 2014 Nov;13(11):799-801. DM9RTXM RU https://www.ncbi.nlm.nih.gov/pubmed/25359367 DMQP6VB DI DMQP6VB DMQP6VB DN LY3200882 DMQP6VB MI TTP4520 DMQP6VB MN TGF-beta receptor type I (TGFBR1) DMQP6VB MT DTT DMQP6VB MA Inhibitor DMQP6VB RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMQP6VB RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DMFDAY7 DI DMFDAY7 DMFDAY7 DN LY3214996 DMFDAY7 MI TT4TQBX DMFDAY7 MN Extracellular signal-regulated kinase 2 (ERK2) DMFDAY7 MT DTT DMFDAY7 MA Inhibitor DMFDAY7 RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMFDAY7 RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DMOV2ML DI DMOV2ML DMOV2ML DN LY3300054 DMOV2ML MI TT8ZLTI DMOV2ML MN Programmed cell death 1 ligand 1 (PD-L1) DMOV2ML MT DTT DMOV2ML RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMOV2ML RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DMG6HLE DI DMG6HLE DMG6HLE DN LY3303560 DMG6HLE MI TTS87KH DMG6HLE MN Microtubule-associated protein tau (MAPT) DMG6HLE MT DTT DMG6HLE RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMG6HLE RU http://phrma-docs.phrma.org/files/dmfile/MID-Update_Alzheimers-Disease_2017-Drug-List.pdf DMD51GC DI DMD51GC DMD51GC DN LY3321367 DMD51GC MI TT1RWL7 DMD51GC MN Hepatitis A virus cellular receptor 2 (TIM3) DMD51GC MT DTT DMD51GC RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMD51GC RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DMONZ1L DI DMONZ1L DMONZ1L DN LY3381916 DMONZ1L MI TTZJYKH DMONZ1L MN Indoleamine 2,3-dioxygenase 1 (IDO1) DMONZ1L MT DTT DMONZ1L MA Inhibitor DMONZ1L RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMONZ1L RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DMB51K2 DI DMB51K2 DMB51K2 DN LY3405105 DMB51K2 MI TTQYF7G DMB51K2 MN Cyclin-dependent kinase 7 (CDK7) DMB51K2 MT DTT DMB51K2 MA Inhibitor DMB51K2 RN CDK7 inhibitors as anticancer drugs. Cancer Metastasis Rev. 2020 Sep;39(3):805-823. DMB51K2 RU https://pubmed.ncbi.nlm.nih.gov/32385714 DMFU0H5 DI DMFU0H5 DMFU0H5 DN LY3410738 DMFU0H5 MI TTV2A1R DMFU0H5 MN Oxalosuccinate decarboxylase (IDH1) DMFU0H5 MT DTT DMFU0H5 MA Inhibitor DMFU0H5 RN LY3410738, a novel inhibitor of mutant IDH1 is more effective than Ivosidenib and potentiates antileukemic activity of standard chemotherapy in preclinical models of acute myeloid leukemia (AML). Cancer Res 2020;80(16 Suppl):Abstract nr 6417. DMFU0H5 RU https://cancerres.aacrjournals.org/content/80/16_Supplement/6417 DM5QO1A DI DM5QO1A DM5QO1A DN LY3415244 DM5QO1A MI TT1RWL7 DM5QO1A MN Hepatitis A virus cellular receptor 2 (TIM3) DM5QO1A MT DTT DM5QO1A MA Inhibitor DM5QO1A RN Safety and Immunogenicity of LY3415244, a Bispecific Antibody Against TIM-3 and PD-L1, in Patients With Advanced Solid Tumors. Clin Cancer Res. 2021 May 15;27(10):2773-2781. DM5QO1A RU https://pubmed.ncbi.nlm.nih.gov/33441294 DM5QO1A DI DM5QO1A DM5QO1A DN LY3415244 DM5QO1A MI TT8ZLTI DM5QO1A MN Programmed cell death 1 ligand 1 (PD-L1) DM5QO1A MT DTT DM5QO1A MA Inhibitor DM5QO1A RN Safety and Immunogenicity of LY3415244, a Bispecific Antibody Against TIM-3 and PD-L1, in Patients With Advanced Solid Tumors. Clin Cancer Res. 2021 May 15;27(10):2773-2781. DM5QO1A RU https://pubmed.ncbi.nlm.nih.gov/33441294 DMZLIWX DI DMZLIWX DMZLIWX DN LY3475070 DMZLIWX MI TTK0O6Y DMZLIWX MN Ecto-5'-nucleotidase (CD73) DMZLIWX MT DTT DMZLIWX MA Inhibitor DMZLIWX RN CD73's Potential as an Immunotherapy Target in Gastrointestinal Cancers. Front Immunol. 2020 Apr 15;11:508. DMZLIWX RU https://pubmed.ncbi.nlm.nih.gov/32351498 DMY8W3S DI DMY8W3S DMY8W3S DN LY3484356 DMY8W3S MI TTZAYWL DMY8W3S MN Estrogen receptor (ESR) DMY8W3S MT DTT DMY8W3S MA Degrader DMY8W3S RN ClinicalTrials.gov (NCT04647487) A Study of LY3484356 in Women With Breast Cancer Before Having Surgery (EMBER-2). U.S. National Institutes of Health. DMY8W3S RU https://clinicaltrials.gov/ct2/show/NCT04647487 DMLXGAI DI DMLXGAI DMLXGAI DN LYS-6KAKT1 DMLXGAI MI TTAZ05C DMLXGAI MN RAC-gamma serine/threonine-protein kinase (AKT3) DMLXGAI MT DTT DMLXGAI MA Modulator DMLXGAI RN DOI: 10.1016/S1359-6349(10)71767-5 DMLXGAI RU https://www.researchgate.net/publication/251667787_62_Preclinical_evaluation_of_LYS6KAKT1_a_novel_highly_selective_orally_bioavailable_dual_inhibitor_of_p70_S6_Kinase_and_AKT_currently_in_phase_I_clinical_trials_for_cancer DMLXGAI DI DMLXGAI DMLXGAI DN LYS-6KAKT1 DMLXGAI MI TT7M3PI DMLXGAI MN Ribosomal protein S6 kinase (S6K) DMLXGAI MT DTT DMLXGAI MA Modulator DMLXGAI RN DOI: 10.1016/S1359-6349(10)71767-5 DMLXGAI RU https://www.researchgate.net/publication/251667787_62_Preclinical_evaluation_of_LYS6KAKT1_a_novel_highly_selective_orally_bioavailable_dual_inhibitor_of_p70_S6_Kinase_and_AKT_currently_in_phase_I_clinical_trials_for_cancer DMHDCSL DI DMHDCSL DMHDCSL DN LZM009 DMHDCSL MI TTNBFWK DMHDCSL MN Programmed cell death protein 1 (PD-1) DMHDCSL MT DTT DMHDCSL RN Development of Inhibitors of the Programmed Cell Death-1/Programmed Cell Death-Ligand 1 Signaling Pathway.J Med Chem. 2019 Feb 28;62(4):1715-1730. DMHDCSL RU https://pubmed.ncbi.nlm.nih.gov/30247903 DMK7UNL DI DMK7UNL DMK7UNL DN M-0004 DMK7UNL MI TT07C3Y DMK7UNL MN 5-HT 4 receptor (HTR4) DMK7UNL MT DTT DMK7UNL MA Agonist DMK7UNL RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 9). DMK7UNL RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=9 DME6UNO DI DME6UNO DME6UNO DN M012 DME6UNO MI TT6Y1PG DME6UNO MN Solute carrier family 40 member 1 (SLC40A1) DME6UNO MT DTT DME6UNO MA Agonist DME6UNO RN Hepcidin agonists as therapeutic tools. Blood. 2018 Apr 19;131(16):1790-1794. DME6UNO RU https://pubmed.ncbi.nlm.nih.gov/29523504 DMP8QY2 DI DMP8QY2 DMP8QY2 DN M1774 DMP8QY2 MI TT8ZYBQ DMP8QY2 MN Serine/threonine-protein kinase ATR (FRP1) DMP8QY2 MT DTT DMP8QY2 MA Inhibitor DMP8QY2 RN National Cancer Institute Drug Dictionary (drug name M1774). DMP8QY2 RU https://www.cancer.gov/publications/dictionaries/cancer-drug/def/atr-kinase-inhibitor-m1774 DM3PVBJ DI DM3PVBJ DM3PVBJ DN M2698 DM3PVBJ MI TTWTSCV DM3PVBJ MN RAC-alpha serine/threonine-protein kinase (AKT1) DM3PVBJ MT DTT DM3PVBJ MA Inhibitor DM3PVBJ RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DM3PVBJ RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DM3PVBJ DI DM3PVBJ DM3PVBJ DN M2698 DM3PVBJ MI TTAZ05C DM3PVBJ MN RAC-gamma serine/threonine-protein kinase (AKT3) DM3PVBJ MT DTT DM3PVBJ MA Inhibitor DM3PVBJ RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DM3PVBJ RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DM3PVBJ DI DM3PVBJ DM3PVBJ DN M2698 DM3PVBJ MI TTG0U4H DM3PVBJ MN Ribosomal protein S6 kinase beta-1 (S6K1) DM3PVBJ MT DTT DM3PVBJ MA Inhibitor DM3PVBJ RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DM3PVBJ RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DM6PI5B DI DM6PI5B DM6PI5B DN M3258 DM6PI5B MI TTEAD9J DM6PI5B MN Proteasome beta-8 (PS beta-8) DM6PI5B MT DTT DM6PI5B MA Inhibitor DM6PI5B RN Clinical pipeline report, company report or official report of EMD Serono. DM6PI5B RU https://medical.emdserono.com/en_US/home/oncology/m3258.html DMG98QO DI DMG98QO DMG98QO DN M3541 DMG98QO MI TTKBM7V DMG98QO MN ATM serine/threonine kinase (ATM) DMG98QO MT DTT DMG98QO MA Inhibitor DMG98QO RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMG98QO RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DMQBO3V DI DMQBO3V DMQBO3V DN M4344 DMQBO3V MI TT8ZYBQ DMQBO3V MN Serine/threonine-protein kinase ATR (FRP1) DMQBO3V MT DTT DMQBO3V MA Inhibitor DMQBO3V RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMQBO3V RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DM6J085 DI DM6J085 DM6J085 DN M6223 DM6J085 MI TTWNL74 DM6J085 MN V-set and immunoglobulin domain-containing protein 9 (TIGIT) DM6J085 MT DTT DM6J085 MA Inhibitor DM6J085 RN ClinicalTrials.gov (NCT04457778) First in Human Study of M6223. U.S. National Institutes of Health. DM6J085 RU https://clinicaltrials.gov/ct2/show/NCT04457778 DMDK4MG DI DMDK4MG DMDK4MG DN M7583 DMDK4MG MI TTGM6VW DMDK4MG MN Tyrosine-protein kinase BTK (ATK) DMDK4MG MT DTT DMDK4MG MA Inhibitor DMDK4MG RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMDK4MG RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DM132EG DI DM132EG DM132EG DN M802 DM132EG MI TT6EO5L DM132EG MN Erbb2 tyrosine kinase receptor (HER2) DM132EG MT DTT DM132EG MA Inhibitor DM132EG RN A novel asymmetrical anti-HER2/CD3 bispecific antibody exhibits potent cytotoxicity for HER2-positive tumor cells. J Exp Clin Cancer Res. 2019 Aug 14;38(1):355. DM132EG RU https://pubmed.ncbi.nlm.nih.gov/31412896 DM132EG DI DM132EG DM132EG DN M802 DM132EG MI TTUN7MC DM132EG MN T-cell surface glycoprotein CD3 (CD3) DM132EG MT DTT DM132EG MA Inhibitor DM132EG RN A novel asymmetrical anti-HER2/CD3 bispecific antibody exhibits potent cytotoxicity for HER2-positive tumor cells. J Exp Clin Cancer Res. 2019 Aug 14;38(1):355. DM132EG RU https://pubmed.ncbi.nlm.nih.gov/31412896 DMZ9NVP DI DMZ9NVP DMZ9NVP DN M8891 DMZ9NVP MI TTZL0OI DMZ9NVP MN Methionine aminopeptidase 2 (METAP2) DMZ9NVP MT DTT DMZ9NVP MA Inhibitor DMZ9NVP RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMZ9NVP RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DMZUM67 DI DMZUM67 DMZUM67 DN M9241 DMZUM67 MI TTG68FB DMZUM67 MN Interleukine 12 (IL-12) DMZUM67 MT DTT DMZUM67 MA Replacement DMZUM67 RN Clinical pipeline report, company report or official report of EMD Serono. DMZUM67 RU https://medical.emdserono.com/content/healthcare/biopharma/usmi/en_US/home/immuno-oncology/m9241--nhs-il12--.html DM59TI2 DI DM59TI2 DM59TI2 DN M9831 DM59TI2 MI TTK3PY9 DM59TI2 MN DNA-dependent protein kinase catalytic (PRKDC) DM59TI2 MT DTT DM59TI2 MA Inhibitor DM59TI2 RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DM59TI2 RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DM0HKU7 DI DM0HKU7 DM0HKU7 DN Macozinone DM0HKU7 MI TTLOHU4 DM0HKU7 MN Mycobacterium Decaprenylphosphoryl-beta-D-ribose oxidase (McyB dprE1) DM0HKU7 MT DTT DM0HKU7 MA Inhibitor DM0HKU7 RN Spirocyclic and Bicyclic 8-Nitrobenzothiazinones for Tuberculosis with Improved Physicochemical and Pharmacokinetic Properties. ACS Med Chem Lett. 2019 Feb 23;10(3):348-351. DM0HKU7 RU https://pubmed.ncbi.nlm.nih.gov/30891138 DM9F15C DI DM9F15C DM9F15C DN MAU868 DM9F15C MI TT09JLE DM9F15C MN BV virus Major capsid protein VP1 (BKV VP1) DM9F15C MT DTT DM9F15C MA Inhibitor DM9F15C RN Clinical pipeline report, company report or official report of Amplyx Pharmaceuticals. DM9F15C RU https://amplyx.com/our-pipeline/ DMMP7XG DI DMMP7XG DMMP7XG DN MAXY-4 DMMP7XG MI TTFZDNP DMMP7XG MN Activation B7-1 antigen (CD80) DMMP7XG MT DTT DMMP7XG MA Inhibitor DMMP7XG RN Trans-endocytosis of CD80 and CD86: a molecular basis for the cell-extrinsic function of CTLA-4. Science. 2011 Apr 29;332(6029):600-3. DMMP7XG RU https://pubmed.ncbi.nlm.nih.gov/21474713 DMMP7XG DI DMMP7XG DMMP7XG DN MAXY-4 DMMP7XG MI TTHGXBU DMMP7XG MN T-lymphocyte activation antigen CD86 (FUN1) DMMP7XG MT DTT DMMP7XG MA Inhibitor DMMP7XG RN Trans-endocytosis of CD80 and CD86: a molecular basis for the cell-extrinsic function of CTLA-4. Science. 2011 Apr 29;332(6029):600-3. DMMP7XG RU https://pubmed.ncbi.nlm.nih.gov/21474713 DMSZ8HT DI DMSZ8HT DMSZ8HT DN MazF gene therapy DMSZ8HT MI TTRBUYN DMSZ8HT MN Ribonuclease (RNase) DMSZ8HT MT DTT DMSZ8HT MA Modulator DMSZ8HT RN Clinical pipeline report, company report or official report of Takara Bio. DMSZ8HT RU http://www.takara-bio.com/medi_e/ DMLA1QD DI DMLA1QD DMLA1QD DN MB-101 DMLA1QD MI TTMPZ7V DMLA1QD MN Interleukin 13 receptor alpha-2 (IL13RA2) DMLA1QD MT DTT DMLA1QD MA Immunomodulator DMLA1QD RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMLA1QD RU http://phrma-docs.phrma.org/files/dmfile/MID_Immuno-Oncology-2017_Drug-List1.pdf DMS0P5O DI DMS0P5O DMS0P5O DN MB-103 DMS0P5O MI TT6EO5L DMS0P5O MN Erbb2 tyrosine kinase receptor (HER2) DMS0P5O MT DTT DMS0P5O RN Clinical pipeline report, company report or official report of Mustang Bio. DMS0P5O RU https://www.mustangbio.com/pipeline/ DMRP4BM DI DMRP4BM DMRP4BM DN MB-104 DMRP4BM MI TT7ILZ1 DMRP4BM MN SLAM family member 7 SLAMF7 (CS1) DMRP4BM MT DTT DMRP4BM RN Clinical pipeline report, company report or official report of Mustang Bio. DMRP4BM RU https://www.mustangbio.com/pipeline/ DMVGTP6 DI DMVGTP6 DMVGTP6 DN MB-105 DMVGTP6 MI TT9T4AV DMVGTP6 MN Prostate stem cell antigen (PSCA) DMVGTP6 MT DTT DMVGTP6 RN Clinical pipeline report, company report or official report of Mustang Bio. DMVGTP6 RU https://www.mustangbio.com/pipeline/ DMPE0KD DI DMPE0KD DMPE0KD DN MB-110 DMPE0KD MI TTCJ2X8 DMPE0KD MN Hepatitis C virus Non-structural 5A (HCV NS5A) DMPE0KD MT DTT DMPE0KD MA Inhibitor DMPE0KD RN Clinical pipeline report, company report or official report of Microbio. DMPE0KD RU https://www.microbio.com.tw/home_03.php?p=7&a=15 DM85AXS DI DM85AXS DM85AXS DN MBS301 DM85AXS MI TT6EO5L DM85AXS MN Erbb2 tyrosine kinase receptor (HER2) DM85AXS MT DTT DM85AXS MA Inhibitor DM85AXS RN Clinical pipeline report, company report or official report of Beijing Mabworks Biotech. DM85AXS RU http://www.mab-works.com/product/5.html DMTXIZ1 DI DMTXIZ1 DMTXIZ1 DN MBX-700 DMTXIZ1 MI TTMVBWH DMTXIZ1 MN Hepatitis C virus RNA-directed RNA polymerase (HCV NS5B) DMTXIZ1 MT DTT DMTXIZ1 MA Inhibitor DMTXIZ1 RN Clinical pipeline report, company report or official report of Microbiotix Inc. DMTXIZ1 RU http://www.microbiotix.com/therapeutic-programs-hcv.htm DMFIS4D DI DMFIS4D DMFIS4D DN MCD-386 DMFIS4D MI TTZ9SOR DMFIS4D MN Muscarinic acetylcholine receptor M1 (CHRM1) DMFIS4D MT DTT DMFIS4D MA Agonist DMFIS4D RN The processing of the selective M1 agonist CDD-0102-J by human hepatic drug metabolizing enzymes. Am J Ther. 2005 Jul-Aug;12(4):300-5. DMFIS4D RU https://pubmed.ncbi.nlm.nih.gov/16041192 DM8CGUV DI DM8CGUV DM8CGUV DN MCLA-145 DM8CGUV MI TTPW9LJ DM8CGUV MN Co-stimulatory molecule 4-1BB (CD137) DM8CGUV MT DTT DM8CGUV MA Agonist DM8CGUV RN Clinical pipeline report, company report or official report of Merus. DM8CGUV RU https://merus.nl/publication-category/mcla-145/ DM8CGUV DI DM8CGUV DM8CGUV DN MCLA-145 DM8CGUV MI TT8ZLTI DM8CGUV MN Programmed cell death 1 ligand 1 (PD-L1) DM8CGUV MT DTT DM8CGUV MA Agonist DM8CGUV RN Clinical pipeline report, company report or official report of Merus. DM8CGUV RU https://merus.nl/pipeline/ DMF0O3X DI DMF0O3X DMF0O3X DN MCLA-158 DMF0O3X MI TTGKNB4 DMF0O3X MN Epidermal growth factor receptor (EGFR) DMF0O3X MT DTT DMF0O3X MA Inhibitor DMF0O3X RN Clinical pipeline report, company report or official report of Merus. DMF0O3X RU https://merus.nl/pipeline/ DMF0O3X DI DMF0O3X DMF0O3X DN MCLA-158 DMF0O3X MI TTTSGRH DMF0O3X MN Leucine-rich repeat-containing GPCR 5 (LGR5) DMF0O3X MT DTT DMF0O3X MA Inhibitor DMF0O3X RN Clinical pipeline report, company report or official report of Merus. DMF0O3X RU https://merus.nl/pipeline/ DMW9YOJ DI DMW9YOJ DMW9YOJ DN MCP-201 DMW9YOJ MI TT27RFC DMW9YOJ MN Opioid receptor delta (OPRD1) DMW9YOJ MT DTT DMW9YOJ MA Agonist DMW9YOJ RN US patent application no. 6,924,288, Enantiomerically pure opioid diarylmethylpiperzine and methods of using same. DMW9YOJ RU http://www.google.com/patents/US6924288 DMW9YOJ DI DMW9YOJ DMW9YOJ DN MCP-201 DMW9YOJ MI TTQW87Y DMW9YOJ MN Opioid receptor kappa (OPRK1) DMW9YOJ MT DTT DMW9YOJ MA Agonist DMW9YOJ RN US patent application no. 6,924,288, Enantiomerically pure opioid diarylmethylpiperzine and methods of using same. DMW9YOJ RU http://www.google.com/patents/US6924288 DMW9YOJ DI DMW9YOJ DMW9YOJ DN MCP-201 DMW9YOJ MI TTKWM86 DMW9YOJ MN Opioid receptor mu (MOP) DMW9YOJ MT DTT DMW9YOJ MA Agonist DMW9YOJ RN US patent application no. 6,924,288, Enantiomerically pure opioid diarylmethylpiperzine and methods of using same. DMW9YOJ RU http://www.google.com/patents/US6924288 DM65B7G DI DM65B7G DM65B7G DN MCP-202 DM65B7G MI TT27RFC DM65B7G MN Opioid receptor delta (OPRD1) DM65B7G MT DTT DM65B7G MA Agonist DM65B7G RN Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800018026) DM65B7G RU http://adisinsight.springer.com/drugs/800018026 DMAESQI DI DMAESQI DMAESQI DN MCY-M11 DMAESQI MI TT4RXME DMAESQI MN Mesothelin (MSLN) DMAESQI MT DTT DMAESQI RN Clinical pipeline report, company report or official report of MaxCyte. DMAESQI RU https://maxcyte.com/carma-cell-therapies-expands-phase-i-trial-of-anti-mesothelin-mrna-car-pbmc-cell-therapy-mcy-m11/ DM1DISM DI DM1DISM DM1DISM DN MDAM (y-methylene-10-deazaaminopterin) DM1DISM MI TTYZVDJ DM1DISM MN Dihydrofolate reductase (DHFR) DM1DISM MT DTT DM1DISM MA Inhibitor DM1DISM RN Evaluation of the importance of hydrophobic interactions in drug binding to dihydrofolate reductase. J Med Chem. 1988 Jan;31(1):129-37. DM1DISM RU https://pubmed.ncbi.nlm.nih.gov/3275776 DMAQ24G DI DMAQ24G DMAQ24G DN MDCO-216 DMAQ24G MI TT7GN3U DMAQ24G MN Apolipoprotein A-I (APOA1) DMAQ24G MT DTT DMAQ24G MA Modulator DMAQ24G RN MDCO-216 (Apo A-I Milano/POPC Complex) Administered to Cynomolgus Monkeys Induces Pronounced Changes in Plasma Lipids and Apolipoproteins. Circulation. 2011; 124: A10978. DMAQ24G RU https://circ.ahajournals.org/cgi/content/meeting_abstract/124/21_MeetingAbstracts/A10978 DMC60S8 DI DMC60S8 DMC60S8 DN MDL-27531 DMC60S8 MI TTZ8EM9 DMC60S8 MN Glycine receptor (GlyR) DMC60S8 MT DTT DMC60S8 MA Modulator DMC60S8 RN MDL 27,531 reduces spontaneous hindlimb contractions in rats with chronic transections of the spinal cord. Neurosci Lett. 1992 Nov 23;147(1):101-5. DMC60S8 RU https://pubmed.ncbi.nlm.nih.gov/1480315 DML5FX2 DI DML5FX2 DML5FX2 DN MDX-018 DML5FX2 MI TTCTE1G DML5FX2 MN Interleukin-8 (IL8) DML5FX2 MT DTT DML5FX2 MA Modulator DML5FX2 RN Company report (Genmab) DML5FX2 RU http://www.genmab.com/product-pipeline/products-in-development/humax-il8 DM0RIQF DI DM0RIQF DM0RIQF DN MDX-1203 DM0RIQF MI TTNCIE0 DM0RIQF MN CD70 antigen (CD27-L) DM0RIQF MT DTT DM0RIQF RN J Clin Oncol 32:5s, 2014 (suppl; abstr 2558). DM0RIQF RU http://meetinglibrary.asco.org/content/130447-144 DM3402P DI DM3402P DM3402P DN MDX-1411 DM3402P MI TTNCIE0 DM3402P MN CD70 antigen (CD27-L) DM3402P MT DTT DM3402P RN Bristol-Myers Squibb swallows last of antibody pioneers. Nat Biotechnol. 2009 Sep;27(9):781-3. DM3402P RU https://pubmed.ncbi.nlm.nih.gov/19741612 DMEMQ5J DI DMEMQ5J DMEMQ5J DN ME-1071 DMEMQ5J MI TTHI19T DMEMQ5J MN Staphylococcus Beta-lactamase (Stap-coc blaZ) DMEMQ5J MT DTT DMEMQ5J MA Inhibitor DMEMQ5J RN Multidrug-resistant Gram-negative bacterial infections: are you ready for the challenge. Curr Clin Pharmacol. 2014 Feb;9(1):27-38. DMEMQ5J RU https://pubmed.ncbi.nlm.nih.gov/23489027 DM39PSZ DI DM39PSZ DM39PSZ DN ME1100 DM39PSZ MI TTOVFH2 DM39PSZ MN Bacterial 30S ribosomal RNA (Bact 30S rRNA) DM39PSZ MT DTT DM39PSZ MA Inhibitor DM39PSZ RN ClinicalTrials.gov (NCT01961830) Intrapulmonary Pharmacokinetics of ME1100 in Healthy Volunteers. U.S. National Institutes of Health. DM39PSZ RU https://clinicaltrials.gov/ct2/show/NCT01961830 DMFNYQ9 DI DMFNYQ9 DMFNYQ9 DN ME-401 DMFNYQ9 MI TTGBPJE DMFNYQ9 MN PI3-kinase delta (PIK3CD) DMFNYQ9 MT DTT DMFNYQ9 MA Inhibitor DMFNYQ9 RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMFNYQ9 RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DMYVBU6 DI DMYVBU6 DMYVBU6 DN MEDI0562 DMYVBU6 MI TTL31H0 DMYVBU6 MN OX40L receptor (CD134) DMYVBU6 MT DTT DMYVBU6 MA Agonist DMYVBU6 RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMYVBU6 RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DMPLFBV DI DMPLFBV DMPLFBV DN MEDI0680 DMPLFBV MI TTNBFWK DMPLFBV MN Programmed cell death protein 1 (PD-1) DMPLFBV MT DTT DMPLFBV RN A Phase Ib/II open-label study to evaluate the safety and efficacy of MEDI-551 in combination with immunomodulating therapy in patients with relapsed or refractory aggressive B cell lymphomas. J Immunother Cancer. 2014; 2(Suppl 3): P73. DMPLFBV RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4288733/ DMD9OVI DI DMD9OVI DMD9OVI DN MEDI1191 DMD9OVI MI TTG68FB DMD9OVI MN Interleukine 12 (IL-12) DMD9OVI MT DTT DMD9OVI MA Replacement DMD9OVI RN Intratumoral IL12 mRNA Therapy Promotes TH1 Transformation of the Tumor Microenvironment. Clin Cancer Res. 2020 Dec 1;26(23):6284-6298. DMD9OVI RU https://pubmed.ncbi.nlm.nih.gov/32817076 DMQDBSU DI DMQDBSU DMQDBSU DN MEDI1341 DMQDBSU MI TT08OSU DMQDBSU MN Synuclein alpha (SNCA) DMQDBSU MT DTT DMQDBSU MA Inhibitor DMQDBSU RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMQDBSU RU http://phrma-docs.phrma.org/files/dmfile/MID_Neurological-Disorders-Drug-List_2018.pdf DMX0DUH DI DMX0DUH DMX0DUH DN MEDI2228 DMX0DUH MI TTZ3P4W DMX0DUH MN B-cell maturation protein (TNFRSF17) DMX0DUH MT DTT DMX0DUH MA Inhibitor DMX0DUH RN A novel BCMA PBD-ADC with ATM/ATR/WEE1 inhibitors or bortezomib induce synergistic lethality in multiple myeloma. Leukemia. 2020 Aug;34(8):2150-2162. DMX0DUH RU https://pubmed.ncbi.nlm.nih.gov/32060401 DMCMYPX DI DMCMYPX DMCMYPX DN MEDI-2338 DMCMYPX MI TTRICUF DMCMYPX MN Interleukin-18 (IL18) DMCMYPX MT DTT DMCMYPX MA Modulator DMCMYPX RN Cytokine inhibition in the treatment of COPD. Int J Chron Obstruct Pulmon Dis. 2014; 9: 397-412. DMCMYPX RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4010626/ DM0H5JD DI DM0H5JD DM0H5JD DN MEDI3617 DM0H5JD MI TTKLQTJ DM0H5JD MN Angiopoietin-2 (ANGPT2) DM0H5JD MT DTT DM0H5JD MA Inhibitor DM0H5JD RN Phase I Study of MEDI3617, a Selective Angiopoietin-2 Inhibitor Alone and Combined with Carboplatin/Paclitaxel, Paclitaxel, or Bevacizumab for Advanced Solid Tumors. Clin Cancer Res. 2018 Jun 15;24(12):2749-2757. DM0H5JD RU https://pubmed.ncbi.nlm.nih.gov/29559563 DMBI4EN DI DMBI4EN DMBI4EN DN MEDI4212 DMBI4EN MI TTYJQTF DMBI4EN MN Immunoglobulin E (IgE) DMBI4EN MT DTT DMBI4EN MA Modulator DMBI4EN RN A novel IgE-neutralizing antibody for the treatment of severe uncontrolled asthma. MAbs. 2014 May-Jun;6(3):756-64. DMBI4EN RU https://pubmed.ncbi.nlm.nih.gov/24583620 DMNI60O DI DMNI60O DMNI60O DN MEDI4276 DMNI60O MI TT6EO5L DMNI60O MN Erbb2 tyrosine kinase receptor (HER2) DMNI60O MT DTT DMNI60O MA Modulator DMNI60O RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMNI60O RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DME7BMT DI DME7BMT DME7BMT DN MEDI4920 DME7BMT MI TTIJP3Q DME7BMT MN TNF related activation protein (CD40LG) DME7BMT MT DTT DME7BMT MA Inhibitor DME7BMT RN ClinicalTrials.gov (NCT02151110) A Phase 1, Randomized, Blinded, Placebo-controlled, Single-ascending Dose Study to Evaluate the Safety and Tolerability of MEDI4920 in Healthy Adults. U.S. National Institutes of Health. DME7BMT RU https://clinicaltrials.gov/ct2/show/NCT02151110 DM3IJQ5 DI DM3IJQ5 DM3IJQ5 DN MEDI5117 DM3IJQ5 MI TTT1V78 DM3IJQ5 MN Interleukin-6 (IL6) DM3IJQ5 MT DTT DM3IJQ5 MA Modulator DM3IJQ5 RN Whole-molecule antibody engineering: generation of a high-affinity anti-IL-6 antibody with extended pharmacokinetics. J Mol Biol. 2011 Aug 26;411(4):791-807. DM3IJQ5 RU https://pubmed.ncbi.nlm.nih.gov/21723291 DM3WP70 DI DM3WP70 DM3WP70 DN MEDI-547 DM3WP70 MI TTRJB2G DM3WP70 MN Ephrin type-A receptor 2 (EPHA2) DM3WP70 MT DTT DM3WP70 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1822). DM3WP70 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1822 DM6ADMG DI DM6ADMG DM6ADMG DN MEDI-557 DM6ADMG MI TT57ID8 DM6ADMG MN Respiratory syncytial virus protein F (RSV F) DM6ADMG MT DTT DM6ADMG RN Motavizumab. Correction in: MAbs. 2010 Sep-Oct; 2(5): 591. DM6ADMG RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2759493/ DMFWPLQ DI DMFWPLQ DMFWPLQ DN MEDI-565 DMFWPLQ MI TTV3XPL DMFWPLQ MN T-cell surface glycoprotein CD3 gamma (CD3G) DMFWPLQ MT DTT DMFWPLQ MA Modulator DMFWPLQ RN Bispecific antibodies rise again. Nat Rev Drug Discov. 2014 Nov;13(11):799-801. DMFWPLQ RU https://www.ncbi.nlm.nih.gov/pubmed/25359367 DMCJFLS DI DMCJFLS DMCJFLS DN MEDI-570 DMCJFLS MI TTE5VP6 DMCJFLS MN Inducible T-cell costimulator (ICOS) DMCJFLS MT DTT DMCJFLS MA Modulator DMCJFLS RN B-cell targeted therapeutics in clinical development. Arthritis Res Ther. 2013;15 Suppl 1:S4. DMCJFLS RU https://pubmed.ncbi.nlm.nih.gov/23566679 DMNL8MO DI DMNL8MO DMNL8MO DN MEDI-573 DMNL8MO MI TTT6LOU DMNL8MO MN Insulin-like growth factor-I (IGF1) DMNL8MO MT DTT DMNL8MO MA Modulator DMNL8MO RN Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41. DMNL8MO RU https://www.ncbi.nlm.nih.gov/pubmed/15950434 DMJ1E24 DI DMJ1E24 DMJ1E24 DN MEDI5752 DMJ1E24 MI TTI2S1D DMJ1E24 MN Cytotoxic T-lymphocyte protein 4 (CTLA-4) DMJ1E24 MT DTT DMJ1E24 MA Inhibitor DMJ1E24 RN Bispecific Antibodies to PD-1 and CTLA4: Doubling Down on T Cells to Decouple Efficacy from Toxicity. Cancer Discov. 2021 May;11(5):1008-1010. DMJ1E24 RU https://pubmed.ncbi.nlm.nih.gov/33947716 DMJ1E24 DI DMJ1E24 DMJ1E24 DN MEDI5752 DMJ1E24 MI TTNBFWK DMJ1E24 MN Programmed cell death protein 1 (PD-1) DMJ1E24 MT DTT DMJ1E24 MA Inhibitor DMJ1E24 RN Bispecific Antibodies to PD-1 and CTLA4: Doubling Down on T Cells to Decouple Efficacy from Toxicity. Cancer Discov. 2021 May;11(5):1008-1010. DMJ1E24 RU https://pubmed.ncbi.nlm.nih.gov/33947716 DMPW21Z DI DMPW21Z DMPW21Z DN MEDI-578 DMPW21Z MI TTDN3LF DMPW21Z MN Nerve growth factor (NGF) DMPW21Z MT DTT DMPW21Z MA Modulator DMPW21Z RN Fate of novel painkiller mAbs hangs in balance.Nat Biotechnol.2011 Mar;29(3):173-4. DMPW21Z RU https://www.ncbi.nlm.nih.gov/pubmed/21389990 DM1YSMD DI DM1YSMD DM1YSMD DN MEDI6383 DM1YSMD MI TTBW580 DM1YSMD MN TAX transcriptionally-activated glycoprotein 1 (OX40) DM1YSMD MT DTT DM1YSMD RN J Clin Oncol 33, 2015 (suppl; abstr 3056). DM1YSMD RU http://meetinglibrary.asco.org/content/150554-156 DM8BXDI DI DM8BXDI DM8BXDI DN MEDI7814 DM8BXDI MI TTKANGO DM8BXDI MN Complement C5 (CO5) DM8BXDI MT DTT DM8BXDI MA Modulator DM8BXDI RN Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41. DM8BXDI RU https://www.ncbi.nlm.nih.gov/pubmed/15950434 DM0J7UR DI DM0J7UR DM0J7UR DN MEDI9197 DM0J7UR MI TTRJ1K4 DM0J7UR MN Toll-like receptor 7 (TLR7) DM0J7UR MT DTT DM0J7UR MA Agonist DM0J7UR RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DM0J7UR RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DM0J7UR DI DM0J7UR DM0J7UR DN MEDI9197 DM0J7UR MI TT8CWFK DM0J7UR MN Toll-like receptor 8 (TLR8) DM0J7UR MT DTT DM0J7UR MA Agonist DM0J7UR RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DM0J7UR RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DM1ALHT DI DM1ALHT DM1ALHT DN MEDl-551 DM1ALHT MI TTW640A DM1ALHT MN B-lymphocyte surface antigen B4 (CD19) DM1ALHT MT DTT DM1ALHT RN CD19 as an attractive target for antibody-based therapy. MAbs. 2012 Sep-Oct;4(5):571-7. DM1ALHT RU https://pubmed.ncbi.nlm.nih.gov/22820352 DMA1KQV DI DMA1KQV DMA1KQV DN MEM-1414 DMA1KQV MI TTZ97H5 DMA1KQV MN Phosphodiesterase 4A (PDE4A) DMA1KQV MT DTT DMA1KQV MA Inhibitor DMA1KQV RN The effect of the novel phosphodiesterase-4 inhibitor MEM 1414 on the allergen induced responses in mild asthma. BMC Pulm Med. 2014 Oct 28;14:166. DMA1KQV RU https://pubmed.ncbi.nlm.nih.gov/25351474 DMA1KQV DI DMA1KQV DMA1KQV DN MEM-1414 DMA1KQV MI TTVIAT9 DMA1KQV MN Phosphodiesterase 4B (PDE4B) DMA1KQV MT DTT DMA1KQV MA Inhibitor DMA1KQV RN The effect of the novel phosphodiesterase-4 inhibitor MEM 1414 on the allergen induced responses in mild asthma. BMC Pulm Med. 2014 Oct 28;14:166. DMA1KQV RU https://pubmed.ncbi.nlm.nih.gov/25351474 DMA1KQV DI DMA1KQV DMA1KQV DN MEM-1414 DMA1KQV MI TTSKMI8 DMA1KQV MN Phosphodiesterase 4D (PDE4D) DMA1KQV MT DTT DMA1KQV MA Inhibitor DMA1KQV RN The effect of the novel phosphodiesterase-4 inhibitor MEM 1414 on the allergen induced responses in mild asthma. BMC Pulm Med. 2014 Oct 28;14:166. DMA1KQV RU https://pubmed.ncbi.nlm.nih.gov/25351474 DME18UM DI DME18UM DME18UM DN MER-102 DME18UM MI TT4QPUL DME18UM MN Antithrombin-III (ATIII) DME18UM MT DTT DME18UM MA Inhibitor DME18UM RN Clinical pipeline report, company report or official report of Merrion's GIPET technology. DME18UM RU http://www.merrionpharma.com/content/portfolio/mer102.asp DMQSJ9T DI DMQSJ9T DMQSJ9T DN Meso-CART DMQSJ9T MI TT4RXME DMQSJ9T MN Mesothelin (MSLN) DMQSJ9T MT DTT DMQSJ9T MA CAR-T-Cell-Therapy DMQSJ9T RN ClinicalTrials.gov (NCT02706782) A Study of Mesothelin Redirected Autologous T Cells for Advanced Pancreatic Carcinoma DMQSJ9T RU https://clinicaltrials.gov/ct2/show/NCT02706782 DMHXA79 DI DMHXA79 DMHXA79 DN Mesothelin-targeted T cells DMHXA79 MI TT4RXME DMHXA79 MN Mesothelin (MSLN) DMHXA79 MT DTT DMHXA79 MA CAR-T-Cell-Therapy DMHXA79 RN ClinicalTrials.gov (NCT02792114) T-Cell Therapy for Advanced Breast Cancer DMHXA79 RU https://clinicaltrials.gov/ct2/show/NCT02792114 DMTQ4PN DI DMTQ4PN DMTQ4PN DN Metastat DMTQ4PN MI TTLM12X DMTQ4PN MN Matrix metalloproteinase-2 (MMP-2) DMTQ4PN MT DTT DMTQ4PN MA Inhibitor DMTQ4PN RN Strategies for MMP inhibition in cancer: innovations for the post-trial era. Nat Rev Cancer. 2002 Sep;2(9):657-72. DMTQ4PN RU https://pubmed.ncbi.nlm.nih.gov/12209155 DMQE4IX DI DMQE4IX DMQE4IX DN MG-1102 DMQE4IX MI TTGUMYS DMQE4IX MN Apolipoprotein(a) (LPA) DMQE4IX MT DTT DMQE4IX MA Modulator DMQE4IX RN Targeted antivascular therapy with the apolipoprotein(a) kringle V, rhLK8, inhibits the growth and metastasis of human prostate cancer in an orthotopic nude mouse model. Neoplasia. 2012 Apr;14(4):335-43. DMQE4IX RU https://pubmed.ncbi.nlm.nih.gov/22577348 DM2PVLH DI DM2PVLH DM2PVLH DN MGA271 DM2PVLH MI TT6CQUM DM2PVLH MN B7 homolog 3 (CD276) DM2PVLH MT DTT DM2PVLH MA Modulator DM2PVLH RN T Cell Coinhibition and Immunotherapy in Human Breast Cancer. Discov Med. 2012 October; 14(77): 229-236. DM2PVLH RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4107447/ DMQB4VN DI DMQB4VN DMQB4VN DN MGD006 DMQB4VN MI TTENHJ0 DMQB4VN MN Interleukin 3 receptor alpha (IL3RA) DMQB4VN MT DTT DMQB4VN MA Modulator DMQB4VN RN A CD3xCD123 bispecific DART for redirecting host T cells to myelogenous leukemia: preclinical activity and safety in nonhuman primates.Sci Transl Med.2015 May 27;7(289):289ra82. DMQB4VN RU https://www.ncbi.nlm.nih.gov/pubmed/26019218 DMQB4VN DI DMQB4VN DMQB4VN DN MGD006 DMQB4VN MI TTUN7MC DMQB4VN MN T-cell surface glycoprotein CD3 (CD3) DMQB4VN MT DTT DMQB4VN MA Modulator DMQB4VN RN A Phase I trial of MGD006 in patients with relapsed acute myeloid leukemia (AML). J Immunother Cancer. 2014; 2(Suppl 3): P87. DMQB4VN RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4288763/ DME4B8I DI DME4B8I DME4B8I DN MGD009 DME4B8I MI TT6CQUM DME4B8I MN B7 homolog 3 (CD276) DME4B8I MT DTT DME4B8I MA Immunomodulator DME4B8I RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DME4B8I RU http://phrma-docs.phrma.org/files/dmfile/MID_Immuno-Oncology-2017_Drug-List1.pdf DMA368V DI DMA368V DMA368V DN MGD010 DMA368V MI TTBN5I7 DMA368V MN B-cell-specific glycoprotein B29 (CD79B) DMA368V MT DTT DMA368V MA Modulator DMA368V RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMA368V RU http://phrma-docs.phrma.org/files/dmfile/medicines-in-development-drug-list-autoimmune-diseases.pdf DMA368V DI DMA368V DMA368V DN MGD010 DMA368V MI TT5RWKQ DMA368V MN Immunoglobulin gamma Fc receptor IIB (FCGR2B) DMA368V MT DTT DMA368V MA Modulator DMA368V RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMA368V RU http://phrma-docs.phrma.org/files/dmfile/medicines-in-development-drug-list-autoimmune-diseases.pdf DMZN5QX DI DMZN5QX DMZN5QX DN MGD014 DMZN5QX MI TTEC2T3 DMZN5QX MN Human immunodeficiency virus Envelope glycoprotein gp160 (HIV env) DMZN5QX MT DTT DMZN5QX MA Inhibitor DMZN5QX RN Clinical pipeline report, company report or official report of MacroGenics. DMZN5QX RU https://www.macrogenics.com/mgd014/ DMZN5QX DI DMZN5QX DMZN5QX DN MGD014 DMZN5QX MI TTUN7MC DMZN5QX MN T-cell surface glycoprotein CD3 (CD3) DMZN5QX MT DTT DMZN5QX MA Inhibitor DMZN5QX RN Clinical pipeline report, company report or official report of MacroGenics. DMZN5QX RU https://www.macrogenics.com/mgd014/ DM2BYWI DI DM2BYWI DM2BYWI DN MGD019 DM2BYWI MI TTI2S1D DM2BYWI MN Cytotoxic T-lymphocyte protein 4 (CTLA-4) DM2BYWI MT DTT DM2BYWI MA Inhibitor DM2BYWI RN Development and Preliminary Clinical Activity of PD-1-Guided CTLA-4 Blocking Bispecific DART Molecule. Cell Rep Med. 2020 Dec 22;1(9):100163. DM2BYWI RU https://pubmed.ncbi.nlm.nih.gov/33377134 DM2BYWI DI DM2BYWI DM2BYWI DN MGD019 DM2BYWI MI TTNBFWK DM2BYWI MN Programmed cell death protein 1 (PD-1) DM2BYWI MT DTT DM2BYWI MA Inhibitor DM2BYWI RN Development and Preliminary Clinical Activity of PD-1-Guided CTLA-4 Blocking Bispecific DART Molecule. Cell Rep Med. 2020 Dec 22;1(9):100163. DM2BYWI RU https://pubmed.ncbi.nlm.nih.gov/33377134 DMTS5VF DI DMTS5VF DMTS5VF DN MGN-1706 DMTS5VF MI TTSHG0T DMTS5VF MN Toll-like receptor 9 (TLR9) DMTS5VF MT DTT DMTS5VF MA Agonist DMTS5VF RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1759). DMTS5VF RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1759 DMU9VDS DI DMU9VDS DMU9VDS DN Mibefradil DMU9VDS MI DE4LYSA DMU9VDS MN Cytochrome P450 3A4 (CYP3A4) DMU9VDS MT DME DMU9VDS MA Metabolism DMU9VDS RN Effect of mibefradil on CYP3A4 in vivo. J Clin Pharmacol. 2003 Oct;43(10):1091-100. DMU9VDS RU https://www.ncbi.nlm.nih.gov/pubmed/?term=14517191 DMU9VDS DI DMU9VDS DMU9VDS DN Mibefradil DMU9VDS MI DTUGYRD DMU9VDS MN P-glycoprotein 1 (ABCB1) DMU9VDS MT DTP DMU9VDS MA Substrate DMU9VDS RN Human intestinal transporter database: QSAR modeling and virtual profiling of drug uptake, efflux and interactions. Pharm Res. 2013 Apr;30(4):996-1007. DMU9VDS RU https://doi.org/10.1007/s11095-012-0935-x DMU9VDS DI DMU9VDS DMU9VDS DN Mibefradil DMU9VDS MI TTZPWGN DMU9VDS MN Voltage-gated calcium channel alpha Cav3.2 (CACNA1H) DMU9VDS MT DTT DMU9VDS MA Inhibitor DMU9VDS RN Mibefradil block of cloned T-type calcium channels. J Pharmacol Exp Ther. 2000 Oct;295(1):302-8. DMU9VDS RU https://pubmed.ncbi.nlm.nih.gov/10991994 DMTUVCG DI DMTUVCG DMTUVCG DN MIK665 DMTUVCG MI TTL53M6 DMTUVCG MN Induced myeloid leukemia cell differentiation protein Mcl-1 (MCL1) DMTUVCG MT DTT DMTUVCG MA Inhibitor DMTUVCG RN MCL1 inhibitors S63845/MIK665 plus Navitoclax synergistically kill difficult-to-treat melanoma cells. Cell Death Dis. 2020 Jun 8;11(6):443. DMTUVCG RU https://pubmed.ncbi.nlm.nih.gov/32513939 DMDER9S DI DMDER9S DMDER9S DN Minnelide DMDER9S MI TTHYBIX DMDER9S MN Heat shock protein 70 (HSP70) DMDER9S MT DTT DMDER9S MA Inhibitor DMDER9S RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMDER9S RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DM5VEN9 DI DM5VEN9 DM5VEN9 DN Minnelide 001 DM5VEN9 MI TTHYBIX DM5VEN9 MN Heat shock protein 70 (HSP70) DM5VEN9 MT DTT DM5VEN9 MA Modulator DM5VEN9 RN Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41. DM5VEN9 RU https://www.ncbi.nlm.nih.gov/pubmed/15950434 DMCPF90 DI DMCPF90 DMCPF90 DN Mivebresib DMCPF90 MI TTE4BSY DMCPF90 MN Bromodomain and extraterminal domain protein (BET) DMCPF90 MT DTT DMCPF90 MA Inhibitor DMCPF90 RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMCPF90 RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DMFLP21 DI DMFLP21 DMFLP21 DN MK 8719 DMFLP21 MI TT2I6UX DMFLP21 MN Beta-N-acetylhexosaminidase (OGA) DMFLP21 MT DTT DMFLP21 MA Inhibitor DMFLP21 RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMFLP21 RU http://phrma-docs.phrma.org/files/dmfile/MID_Neurological-Disorders-Drug-List_2018.pdf DM2TAUR DI DM2TAUR DM2TAUR DN MK-0731 DM2TAUR MI TTTRP0H DM2TAUR MN Kinesin-like protein KIF11 (KIF11) DM2TAUR MT DTT DM2TAUR MA Inhibitor DM2TAUR RN Kinesins and cancer. Nat Rev Cancer. 2012 Jul 24;12(8):527-39. DM2TAUR RU https://pubmed.ncbi.nlm.nih.gov/22825217 DMHS79I DI DMHS79I DMHS79I DN MK-1092 DMHS79I MI TTNVEIR DMHS79I MN Prostaglandin D2 receptor (PTGDR) DMHS79I MT DTT DMHS79I MA Antagonist DMHS79I RN The challenge of modulating -cell autoimmunity in type 1 diabetes. Lancet Diabetes Endocrinol. 2019 Jan;7(1):52-64. DMHS79I RU https://pubmed.ncbi.nlm.nih.gov/30528099 DME1ZAH DI DME1ZAH DME1ZAH DN MK-1496 DME1ZAH MI TTIYVQP DME1ZAH MN Polo-like kinase 1 (PLK1) DME1ZAH MT DTT DME1ZAH MA Inhibitor DME1ZAH RN J Clin Oncol 29: 2011 (suppl; abstr 3012). DME1ZAH RU http://meetinglibrary.asco.org/content/73894-102 DMKNH8B DI DMKNH8B DMKNH8B DN MK-2118 DMKNH8B MI TTT402Y DMKNH8B MN Stimulator of interferon genes protein (TMEM173) DMKNH8B MT DTT DMKNH8B MA Agonist DMKNH8B RN National Cancer Institute Drug Dictionary (drug name ML2118). DMKNH8B RU https://www.cancer.gov/publications/dictionaries/cancer-drug/def/sting-agonist-mk-2118 DMUHOJP DI DMUHOJP DMUHOJP DN MK-2637 DMUHOJP MI TTHJTF7 DMUHOJP MN Glycine transporter GlyT-1 (SLC6A9) DMUHOJP MT DTT DMUHOJP MA Modulator DMUHOJP RN Characterization of the novel GlyT1 PET tracer [18F]MK-6577 in humans. Synapse. 2015 Jan;69(1):33-40. DMUHOJP RU https://pubmed.ncbi.nlm.nih.gov/25196464 DM5EFPS DI DM5EFPS DM5EFPS DN MK-3134 DM5EFPS MI TT9JNIC DM5EFPS MN Histamine H3 receptor (H3R) DM5EFPS MT DTT DM5EFPS MA Agonist DM5EFPS RN Additive effects of a cholinesterase inhibitor and a histamine inverse agonist on scopolamine deficits in humans. Psychopharmacology (Berl). 2011 Dec;218(3):513-24. DM5EFPS RU https://pubmed.ncbi.nlm.nih.gov/21644059 DMG0Q27 DI DMG0Q27 DMG0Q27 DN MK-3281 DMG0Q27 MI TTMVBWH DMG0Q27 MN Hepatitis C virus RNA-directed RNA polymerase (HCV NS5B) DMG0Q27 MT DTT DMG0Q27 MA Inhibitor DMG0Q27 RN Clinical pipeline report, company report or official report of Merck (2011). DMG0Q27 RU http://www.merck.com/index.html DMW2O5D DI DMW2O5D DMW2O5D DN MK-3328 DMW2O5D MI TTHS256 DMW2O5D MN Metabotropic glutamate receptor 5 (mGluR5) DMW2O5D MT DTT DMW2O5D MA Modulator DMW2O5D RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 293). DMW2O5D RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=293 DML5V76 DI DML5V76 DML5V76 DN MK-4166 DML5V76 MI TTG6LA7 DML5V76 MN Activation-inducible TNFR family receptor (TNFRSF18) DML5V76 MT DTT DML5V76 RN Immuno-oncology moves beyond PD-1. Nat Biotechnol. 2015 Jul;33(7):673-5. DML5V76 RU https://pubmed.ncbi.nlm.nih.gov/26153987 DMCA1NX DI DMCA1NX DMCA1NX DN MK-4280 DMCA1NX MI TTNVXAW DMCA1NX MN Lymphocyte activation gene 3 protein (LAG3) DMCA1NX MT DTT DMCA1NX MA Inhibitor DMCA1NX RN Establishment of engineered cell-based assays mediating LAG3 and PD1 immune suppression enables potency measurement of blocking antibodies and assessment of signal transduction. J Immunol Methods. 2018 May;456:7-14. DMCA1NX RU https://pubmed.ncbi.nlm.nih.gov/29427592 DMN40DU DI DMN40DU DMN40DU DN MK-4621 DMN40DU MI TTVB0O3 DMN40DU MN Retinoic acid-inducible gene-1 (RIG-1) DMN40DU MT DTT DMN40DU MA Agonist DMN40DU RN National Cancer Institute Drug Dictionary (drug name RGT100). DMN40DU RU https://www.cancer.gov/publications/dictionaries/cancer-drug/def/rig-i-selective-ligand-rgt100 DMCT37W DI DMCT37W DMCT37W DN MK-4830 DMCT37W MI TTHC6XU DMCT37W MN Leukocyte immunoglobulin-like receptor B2 (LILRB2) DMCT37W MT DTT DMCT37W MA Inhibitor DMCT37W RN National Cancer Institute Drug Dictionary (drug name MK4830). DMCT37W RU https://www.cancer.gov/publications/dictionaries/cancer-drug/def/anti-ilt4-monoclonal-antibody-mk-4830 DMFGYKS DI DMFGYKS DMFGYKS DN MK-5108 DMFGYKS MI TTPS3C0 DMFGYKS MN Aurora kinase A (AURKA) DMFGYKS MT DTT DMFGYKS MA Inhibitor DMFGYKS RN A novel c-Met inhibitor, MK8033, synergizes with carboplatin plus paclitaxel to inhibit ovarian cancer cell growth. Oncol Rep. 2013 May;29(5):2011-8. DMFGYKS RU https://pubmed.ncbi.nlm.nih.gov/23467907 DMFGYKS DI DMFGYKS DMFGYKS DN MK-5108 DMFGYKS MI TT5LS6T DMFGYKS MN Aurora kinase B (AURKB) DMFGYKS MT DTT DMFGYKS MA Inhibitor DMFGYKS RN A novel c-Met inhibitor, MK8033, synergizes with carboplatin plus paclitaxel to inhibit ovarian cancer cell growth. Oncol Rep. 2013 May;29(5):2011-8. DMFGYKS RU https://pubmed.ncbi.nlm.nih.gov/23467907 DMSA27Z DI DMSA27Z DMSA27Z DN MK-6186 DMSA27Z MI TT84ETX DMSA27Z MN Human immunodeficiency virus Reverse transcriptase (HIV RT) DMSA27Z MT DTT DMSA27Z MA Inhibitor DMSA27Z RN Antiviral activity and in vitro mutation development pathways of MK-6186, a novel nonnucleoside reverse transcriptase inhibitor. Antimicrob Agents Chemother. 2012 Jun;56(6):3324-35. DMSA27Z RU https://pubmed.ncbi.nlm.nih.gov/22391531 DMZUA5C DI DMZUA5C DMZUA5C DN MK-6302 DMZUA5C MI TTC70AJ DMZUA5C MN Granulocyte colony-stimulating factor receptor (G-CSF-R) DMZUA5C MT DTT DMZUA5C MA Modulator DMZUA5C RN Merck ditches biogeneric. Nat Biotechnol. 2010 Jul;28(7):636. DMZUA5C RU https://pubmed.ncbi.nlm.nih.gov/20622817 DMV8BI4 DI DMV8BI4 DMV8BI4 DN MK-6325 DMV8BI4 MI TTRHUKY DMV8BI4 MN Hepatitis C virus Serine protease NS4A (HCV NS4A) DMV8BI4 MT DTT DMV8BI4 MA Modulator DMV8BI4 RN Synthesis of bis-macrocyclic HCV protease inhibitor MK-6325 via intramolecular sp -sp Suzuki-Miyaura coupling and ring closing metathesis. Org Lett. 2015 Mar 20;17(6):1533-6. DMV8BI4 RU https://pubmed.ncbi.nlm.nih.gov/25754231 DMBSXZ1 DI DMBSXZ1 DMBSXZ1 DN MK-7162 DMBSXZ1 MI TTZJYKH DMBSXZ1 MN Indoleamine 2,3-dioxygenase 1 (IDO1) DMBSXZ1 MT DTT DMBSXZ1 MA Inhibitor DMBSXZ1 RN ClinicalTrials.gov (NCT03364049) Study of MK-7162 in Combination With Pembrolizumab (MK-3475) in Adult Participants With Advanced Solid Tumors (MK-7162-002). U.S. National Institutes of Health. DMBSXZ1 RU https://clinicaltrials.gov/ct2/show/NCT03364049 DMLQOF1 DI DMLQOF1 DMLQOF1 DN MK-7246 DMLQOF1 MI TTQDMX5 DMLQOF1 MN Prostaglandin D2 receptor 2 (PTGDR2) DMLQOF1 MT DTT DMLQOF1 MA Modulator DMLQOF1 RN Discovery of MK-7246, a selective CRTH2 antagonist for the treatment of respiratory diseases. Bioorg Med Chem Lett. 2011 Jan 1;21(1):288-93. DMLQOF1 RU https://pubmed.ncbi.nlm.nih.gov/21106375 DMLQOF1 DI DMLQOF1 DMLQOF1 DN MK-7246 DMLQOF1 MI DEAZDL8 DMLQOF1 MN UDP-glucuronosyltransferase 2B17 (UGT2B17) DMLQOF1 MT DME DMLQOF1 MA Metabolism DMLQOF1 RN UGT2B17 genetic polymorphisms dramatically affect the pharmacokinetics of MK-7246 in healthy subjects in a first-in-human study. Clin Pharmacol Ther. 2012 Jul;92(1):96-102. DMLQOF1 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=22669291 DMJ2Q6H DI DMJ2Q6H DMJ2Q6H DN MK-7288 DMJ2Q6H MI TT9JNIC DMJ2Q6H MN Histamine H3 receptor (H3R) DMJ2Q6H MT DTT DMJ2Q6H MA Agonist DMJ2Q6H RN Early-stage comparative effectiveness: randomized controlled trial with histamine inverse agonist MK-7288 in excessive daytime sleepiness patients. J Clin Pharmacol. 2013 Dec;53(12):1294-302. DMJ2Q6H RU https://pubmed.ncbi.nlm.nih.gov/24122944 DMA1EDN DI DMA1EDN DMA1EDN DN MK-8033 DMA1EDN MI TTNDSF4 DMA1EDN MN Proto-oncogene c-Met (MET) DMA1EDN MT DTT DMA1EDN MA Inhibitor DMA1EDN RN A novel c-Met inhibitor, MK8033, synergizes with carboplatin plus paclitaxel to inhibit ovarian cancer cell growth. Oncol Rep. 2013 May;29(5):2011-8. DMA1EDN RU https://pubmed.ncbi.nlm.nih.gov/23467907 DMLCTI5 DI DMLCTI5 DMLCTI5 DN MK-8353 DMLCTI5 MI TTKPV6O DMLCTI5 MN Ephrin type-B receptor 2 (EPHB2) DMLCTI5 MT DTT DMLCTI5 MA Inhibitor DMLCTI5 RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMLCTI5 RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DMHTWBL DI DMHTWBL DMHTWBL DN MK-8504 DMHTWBL MI TT84ETX DMHTWBL MN Human immunodeficiency virus Reverse transcriptase (HIV RT) DMHTWBL MT DTT DMHTWBL MA Inhibitor DMHTWBL RN ClinicalTrials.gov (NCT03188523) Activity of MK-8504 in Anti-retroviral-naive, Human Immunodeficiency Virus 1 (HIV-1) Infected Participants (MK-8504-002). U.S. National Institutes of Health. DMHTWBL RU https://clinicaltrials.gov/ct2/show/NCT03188523 DMQHPME DI DMQHPME DMQHPME DN MK-8583 DMQHPME MI TT84ETX DMQHPME MN Human immunodeficiency virus Reverse transcriptase (HIV RT) DMQHPME MT DTT DMQHPME MA Inhibitor DMQHPME RN ClinicalTrials.gov (NCT03552536) MK-8583 Single Dose Study in Human Immunodeficiency Virus Type 1 (HIV-1) Infected Participants (MK-8583-002). U.S. National Institutes of Health. DMQHPME RU https://clinicaltrials.gov/ct2/show/NCT03552536 DMETIBD DI DMETIBD DMETIBD DN MK-8719 DMETIBD MI TT2I6UX DMETIBD MN Beta-N-acetylhexosaminidase (OGA) DMETIBD MT DTT DMETIBD MA Inhibitor DMETIBD RN Discovery of MK-8719, a Potent O-GlcNAcase Inhibitor as a Potential Treatment for Tauopathies. J Med Chem. 2019 Nov 27;62(22):10062-10097. DMETIBD RU https://pubmed.ncbi.nlm.nih.gov/31487175 DMAS1RB DI DMAS1RB DMAS1RB DN MK-8776 DMAS1RB MI TTTU902 DMAS1RB MN Checkpoint kinase-1 (CHK1) DMAS1RB MT DTT DMAS1RB MA Inhibitor DMAS1RB RN Chk1 Inhibitor MK-8776 Restores the Sensitivity of Chemotherapeutics in P-glycoprotein Overexpressing Cancer Cells. Int J Mol Sci. 2019 Aug 22;20(17):4095. DMAS1RB RU https://pubmed.ncbi.nlm.nih.gov/31443367 DMDB3OK DI DMDB3OK DMDB3OK DN MLN-3126 DMDB3OK MI TTIPS8B DMDB3OK MN C-C chemokine receptor type 9 (CCR9) DMDB3OK MT DTT DMDB3OK MA Antagonist DMDB3OK RN Targeting T-cell migration in inflammatory bowel disease. J Intern Med. 2012 Nov;272(5):411-29. DMDB3OK RU https://pubmed.ncbi.nlm.nih.gov/22946654 DMCVO2Y DI DMCVO2Y DMCVO2Y DN MLN-576 DMCVO2Y MI TTGTQHC DMCVO2Y MN DNA topoisomerase I (TOP1) DMCVO2Y MT DTT DMCVO2Y MA Modulator DMCVO2Y RN In vitro and in vivo characterization of XR11576, a novel, orally active, dual inhibitor of topoisomerase I and II. Anticancer Drugs. 2002 Jan;13(1):15-28. DMCVO2Y RU https://pubmed.ncbi.nlm.nih.gov/11914637 DMCVO2Y DI DMCVO2Y DMCVO2Y DN MLN-576 DMCVO2Y MI TT0IHXV DMCVO2Y MN DNA topoisomerase II (TOP2) DMCVO2Y MT DTT DMCVO2Y MA Modulator DMCVO2Y RN In vitro and in vivo characterization of XR11576, a novel, orally active, dual inhibitor of topoisomerase I and II. Anticancer Drugs. 2002 Jan;13(1):15-28. DMCVO2Y RU https://pubmed.ncbi.nlm.nih.gov/11914637 DMWK951 DI DMWK951 DMWK951 DN MLN7243 DMWK951 MI TTU8HT1 DMWK951 MN Ubiquitin-activating enzyme (UBA) DMWK951 MT DTT DMWK951 MA Modulator DMWK951 RN National Cancer Institute Drug Dictionary (drug id 757275). DMWK951 RU http://www.cancer.gov/publications/dictionaries/cancer-drug?cdrid=757275 DMUANF3 DI DMUANF3 DMUANF3 DN MLN8054 DMUANF3 MI TTPS3C0 DMUANF3 MN Aurora kinase A (AURKA) DMUANF3 MT DTT DMUANF3 MA Inhibitor DMUANF3 RN A comparison of physicochemical property profiles of marketed oral drugs and orally bioavailable anti-cancer protein kinase inhibitors in clinical development. Curr Top Med Chem. 2007;7(14):1408-22. DMUANF3 RU https://pubmed.ncbi.nlm.nih.gov/17692029 DMUANF3 DI DMUANF3 DMUANF3 DN MLN8054 DMUANF3 MI DEJGDUW DMUANF3 MN Cytochrome P450 1A2 (CYP1A2) DMUANF3 MT DME DMUANF3 MA Metabolism DMUANF3 RN MLN8054 and Alisertib (MLN8237): discovery of selective oral aurora A inhibitors. ACS Med Chem Lett. 2015 Apr 22;6(6):630-4. DMUANF3 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=26101564 DMUANF3 DI DMUANF3 DMUANF3 DN MLN8054 DMUANF3 MI DE4LYSA DMUANF3 MN Cytochrome P450 3A4 (CYP3A4) DMUANF3 MT DME DMUANF3 MA Metabolism DMUANF3 RN MLN8054 and Alisertib (MLN8237): discovery of selective oral aurora A inhibitors. ACS Med Chem Lett. 2015 Apr 22;6(6):630-4. DMUANF3 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=26101564 DMXQHZC DI DMXQHZC DMXQHZC DN MM-151 DMXQHZC MI TTGKNB4 DMXQHZC MN Epidermal growth factor receptor (EGFR) DMXQHZC MT DTT DMXQHZC MA Antagonist DMXQHZC RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMXQHZC RU http://phrma-docs.phrma.org/files/dmfile/MID_Immuno-Oncology-2017_Drug-List1.pdf DMXQHZC DI DMXQHZC DMXQHZC DN MM-151 DMXQHZC MI TTDC8N2 DMXQHZC MN Erbb3 tyrosine kinase receptor (Erbb-3) DMXQHZC MT DTT DMXQHZC MA Modulator DMXQHZC RN MM-141, an IGF-IR- and ErbB3-directed bispecific antibody, overcomes network adaptations that limit activity of IGF-IR inhibitors. Mol Cancer Ther. 2014 Feb;13(2):410-25. DMXQHZC RU https://pubmed.ncbi.nlm.nih.gov/24282274 DMYSJTR DI DMYSJTR DMYSJTR DN MM-302 DMYSJTR MI TT6EO5L DMYSJTR MN Erbb2 tyrosine kinase receptor (HER2) DMYSJTR MT DTT DMYSJTR MA Modulator DMYSJTR RN Whole-body organ-level and kidney micro-dosimetric evaluations of (64)Cu-loaded HER2/ErbB2-targeted liposomal doxorubicin ((64)Cu-MM-302) in rodents and primates. EJNMMI Res. 2015 Apr 14;5:24. DMYSJTR RU https://pubmed.ncbi.nlm.nih.gov/25918676 DMIMVEX DI DMIMVEX DMIMVEX DN MMI-0100 DMIMVEX MI TTMUG9D DMIMVEX MN MAPK-activated protein kinase 2 (MAPKAPK2) DMIMVEX MT DTT DMIMVEX MA Inhibitor DMIMVEX RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2094). DMIMVEX RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2094 DMAQJHO DI DMAQJHO DMAQJHO DN Monohydroxyethylrutoside DMAQJHO MI TTUDR0C DMAQJHO MN Iron (Fe) DMAQJHO MT DTT DMAQJHO MA Modulator DMAQJHO RN Monohydroxyethylrutoside, a dose-dependent cardioprotective agent, does not affect the antitumor activity of doxorubicin. Clin Cancer Res. 1997 Oct;3(10):1747-54. DMAQJHO RU https://pubmed.ncbi.nlm.nih.gov/9815559 DMM7TBO DI DMM7TBO DMM7TBO DN MORAb-022 DMM7TBO MI TTNYZG2 DMM7TBO MN Granulocyte-macrophage colony-stimulating factor (CSF2) DMM7TBO MT DTT DMM7TBO RN Clinical pipeline report, company report or official report of Morphotek. DMM7TBO RU http://www.morphotek.com/pipeline/MORAb-022.aspx DMM7TBO DI DMM7TBO DMM7TBO DN MORAb-022 DMM7TBO MI TT0T5HK DMM7TBO MN Immunoglobulin gamma-1 heavy NIE (NIE) DMM7TBO MT DTT DMM7TBO RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMM7TBO RU http://phrma-docs.phrma.org/files/dmfile/medicines-in-development-drug-list-autoimmune-diseases.pdf DMTUKW9 DI DMTUKW9 DMTUKW9 DN MORAb-066 DMTUKW9 MI TT38MDJ DMTUKW9 MN Tissue factor (F3) DMTUKW9 MT DTT DMTUKW9 RN Clinical pipeline report, company report or official report of Morphotek. DMTUKW9 RU http://www.morphotek.com/pipeline/MORAb-066.aspx DMJOMD4 DI DMJOMD4 DMJOMD4 DN MP-0112 DMJOMD4 MI TTOHSBA DMJOMD4 MN Vascular endothelial growth factor A (VEGFA) DMJOMD4 MT DTT DMJOMD4 MA Inhibitor DMJOMD4 RN Treatment of exudative age-related macular degeneration with a designed ankyrin repeat protein that binds vascular endothelial growth factor: a phase I/II study. Am J Ophthalmol. 2014 Oct;158(4):724-732.e2. DMJOMD4 RU https://pubmed.ncbi.nlm.nih.gov/24907435 DMQRNTG DI DMQRNTG DMQRNTG DN MP-124 DMQRNTG MI TTEBCY8 DMQRNTG MN Poly [ADP-ribose] polymerase (PARP) DMQRNTG MT DTT DMQRNTG MA Modulator DMQRNTG RN Company report (Mitsubishi Tanabe Pharma) DMQRNTG RU http://www.mt-pharma-america.com/development.php DM5VXWO DI DM5VXWO DM5VXWO DN MP-157 DM5VXWO MI TTQVOEI DM5VXWO MN Angiotensin II receptor type-2 (AGTR2) DM5VXWO MT DTT DM5VXWO MA Agonist DM5VXWO RN As drug target reemerges, the question is to block or stimulate it. Nature Medicine. Spoonful of Medicine. 05 Feb 2014. Cassandra Willyard DM5VXWO RU http://blogs.nature.com/spoonful/2014/02/as-drug-target-reemerges-the-question-is-to-block-or-stimulate-it.html DME7JFM DI DME7JFM DME7JFM DN MR1-1 DME7JFM MI TTGKNB4 DME7JFM MN Epidermal growth factor receptor (EGFR) DME7JFM MT DTT DME7JFM MA Modulator DME7JFM RN A Phase I Study of Immunotoxin, MR1-1. Duke University report. DME7JFM RU http://www.cancer.duke.edu/btc/modules/ClinicalTrials4/index.php?id=72 DMVNLGW DI DMVNLGW DMVNLGW DN MR-1817 DMVNLGW MI TTMI6F5 DMVNLGW MN Transient receptor potential cation channel V1 (TRPV1) DMVNLGW MT DTT DMVNLGW MA Antagonist DMVNLGW RN Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800030745) DMVNLGW RU http://adisinsight.springer.com/drugs/800030745 DMUVGMS DI DMUVGMS DMUVGMS DN MRG-110 DMUVGMS MI TTIXJ2S DMUVGMS MN microRNA hsa-miR-92 (MIR92) DMUVGMS MT DTT DMUVGMS MA Inhibitor DMUVGMS RN Efficiency and Target Derepression of Anti-miR-92a: Results of a First in Human Study. Nucleic Acid Ther. 2020 Dec;30(6):335-345. DMUVGMS RU https://pubmed.ncbi.nlm.nih.gov/32707001 DMFTAWU DI DMFTAWU DMFTAWU DN mRNA-2416 DMFTAWU MI TTBW580 DMFTAWU MN TAX transcriptionally-activated glycoprotein 1 (OX40) DMFTAWU MT DTT DMFTAWU MA Replacement DMFTAWU RN Clinical pipeline report, company report or official report of Moderna Therapeutics. DMFTAWU RU https://www.modernatx.com/mrna-2416 DMUKBI2 DI DMUKBI2 DMUKBI2 DN mRNA-2752 DMUKBI2 MI TTC1GLB DMUKBI2 MN Interleukin-23 (IL23) DMUKBI2 MT DTT DMUKBI2 MA Replacement DMUKBI2 RN Clinical pipeline report, company report or official report of Moderna Therapeutics. DMUKBI2 RU https://www.modernatx.com/mrna-2752 DMUKBI2 DI DMUKBI2 DMUKBI2 DN mRNA-2752 DMUKBI2 MI TT8SLDN DMUKBI2 MN Interleukin-36 gamma (IL36G) DMUKBI2 MT DTT DMUKBI2 MA Replacement DMUKBI2 RN Clinical pipeline report, company report or official report of Moderna Therapeutics. DMUKBI2 RU https://www.modernatx.com/mrna-2752 DMUKBI2 DI DMUKBI2 DMUKBI2 DN mRNA-2752 DMUKBI2 MI TTBW580 DMUKBI2 MN TAX transcriptionally-activated glycoprotein 1 (OX40) DMUKBI2 MT DTT DMUKBI2 MA Replacement DMUKBI2 RN Clinical pipeline report, company report or official report of Moderna Therapeutics. DMUKBI2 RU https://www.modernatx.com/mrna-2752 DMM5N8P DI DMM5N8P DMM5N8P DN MRX-2843 DMM5N8P MI TTGJCWZ DMM5N8P MN Fms-like tyrosine kinase 3 (FLT-3) DMM5N8P MT DTT DMM5N8P MA Inhibitor DMM5N8P RN The MERTK/FLT3 inhibitor MRX-2843 overcomes resistance-conferring FLT3 mutations in acute myeloid leukemia. JCI Insight. 2016 Mar;1(3):e85630. DMM5N8P RU https://pubmed.ncbi.nlm.nih.gov/27158668 DMM5N8P DI DMM5N8P DMM5N8P DN MRX-2843 DMM5N8P MI TTO7LKR DMM5N8P MN Tyrosine-protein kinase Mer (MERTK) DMM5N8P MT DTT DMM5N8P MA Inhibitor DMM5N8P RN The MERTK/FLT3 inhibitor MRX-2843 overcomes resistance-conferring FLT3 mutations in acute myeloid leukemia. JCI Insight. 2016 Mar;1(3):e85630. DMM5N8P RU https://pubmed.ncbi.nlm.nih.gov/27158668 DMWKDOQ DI DMWKDOQ DMWKDOQ DN MRX34 DMWKDOQ MI TT96IGO DMWKDOQ MN microRNA hsa-miR-34 (MIR34) DMWKDOQ MT DTT DMWKDOQ MA Modulator DMWKDOQ RN Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41. DMWKDOQ RU https://www.ncbi.nlm.nih.gov/pubmed/15950434 DM7ER9J DI DM7ER9J DM7ER9J DN MS-553 DM7ER9J MI TTYPXQF DM7ER9J MN Protein kinase C beta (PRKCB) DM7ER9J MT DTT DM7ER9J MA Inhibitor DM7ER9J RN ClinicalTrials.gov (NCT03492125) A Study Of The Selective PKC-beta Inhibitor MS- 553. U.S. National Institutes of Health. DM7ER9J RU https://clinicaltrials.gov/ct2/show/NCT03492125 DMH8VXE DI DMH8VXE DMH8VXE DN MSB2311 DMH8VXE MI TT8ZLTI DMH8VXE MN Programmed cell death 1 ligand 1 (PD-L1) DMH8VXE MT DTT DMH8VXE RN Development of Inhibitors of the Programmed Cell Death-1/Programmed Cell Death-Ligand 1 Signaling Pathway.J Med Chem. 2019 Feb 28;62(4):1715-1730. DMH8VXE RU https://pubmed.ncbi.nlm.nih.gov/30247903 DM6XTZL DI DM6XTZL DM6XTZL DN MSC-1 DM6XTZL MI TTGZ5WN DM6XTZL MN Leukemia inhibitory factor (LIF) DM6XTZL MT DTT DM6XTZL RN National Cancer Institute Drug Dictionary (drug name MSC-1). DM6XTZL RU https://www.cancer.gov/publications/dictionaries/cancer-drug/def/anti-lif-monoclonal-antibody-msc-1 DM6XC8H DI DM6XC8H DM6XC8H DN MSC110 DM6XC8H MI TT0IQER DM6XC8H MN Macrophage colony-stimulating factor 1 (CSF1) DM6XC8H MT DTT DM6XC8H MA Inhibitor DM6XC8H RN Colony-Stimulating Factor-1 Antibody Lacnotuzumab in a Phase 1 Healthy Volunteer Study and Mechanistic Investigation of Safety Outcomes. J Pharmacol Exp Ther. 2019 Jun;369(3):428-442. DM6XC8H RU https://pubmed.ncbi.nlm.nih.gov/30894455 DMEP7HO DI DMEP7HO DMEP7HO DN MSH-372 DMEP7HO MI TT84ETX DMEP7HO MN Human immunodeficiency virus Reverse transcriptase (HIV RT) DMEP7HO MT DTT DMEP7HO MA Inhibitor DMEP7HO RN WO patent application no. 2004,0290,42, Pyrazole derivatives as reverse transcriptase inhibitors. DMEP7HO RU http://www.google.com/patents/WO2004029042A1?cl=en DM1N9YS DI DM1N9YS DM1N9YS DN MSX-122 DM1N9YS MI TTBID49 DM1N9YS MN C-X-C chemokine receptor type 4 (CXCR4) DM1N9YS MT DTT DM1N9YS MA Antagonist DM1N9YS RN Comparative evaluation of CC chemokine-induced migration of murine CD8alpha+ and CD8alpha- dendritic cells and their in vivo trafficking. J Leukoc Biol. 2004 Feb;75(2):275-85. DM1N9YS RU https://pubmed.ncbi.nlm.nih.gov/14597730 DMPCUN5 DI DMPCUN5 DMPCUN5 DN MT-110 DMPCUN5 MI TTZAT79 DMPCUN5 MN T-cell surface glycoprotein CD3 epsilon (CD3E) DMPCUN5 MT DTT DMPCUN5 RN EpCAM/CD3-Bispecific T-cell engaging antibody MT110 eliminates primary human pancreatic cancer stem cells. Clin Cancer Res. 2012 Jan 15;18(2):465-74. DMPCUN5 RU https://pubmed.ncbi.nlm.nih.gov/22096026 DMPCUN5 DI DMPCUN5 DMPCUN5 DN MT-110 DMPCUN5 MI TTV3XPL DMPCUN5 MN T-cell surface glycoprotein CD3 gamma (CD3G) DMPCUN5 MT DTT DMPCUN5 RN EpCAM/CD3-Bispecific T-cell engaging antibody MT110 eliminates primary human pancreatic cancer stem cells. Clin Cancer Res. 2012 Jan 15;18(2):465-74. DMPCUN5 RU https://pubmed.ncbi.nlm.nih.gov/22096026 DMPCUN5 DI DMPCUN5 DMPCUN5 DN MT-110 DMPCUN5 MI TTZ8WH4 DMPCUN5 MN Tumor-associated calcium signal transducer 1 (EPCAM) DMPCUN5 MT DTT DMPCUN5 RN EpCAM/CD3-Bispecific T-cell engaging antibody MT110 eliminates primary human pancreatic cancer stem cells. Clin Cancer Res. 2012 Jan 15;18(2):465-74. DMPCUN5 RU https://pubmed.ncbi.nlm.nih.gov/22096026 DMT0EBU DI DMT0EBU DMT0EBU DN MT-112 DMT0EBU MI TT9G4N0 DMT0EBU MN Glutamate carboxypeptidase II (GCPII) DMT0EBU MT DTT DMT0EBU RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1606). DMT0EBU RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1606 DM5SN0A DI DM5SN0A DM5SN0A DN MT-5111 DM5SN0A MI TT6EO5L DM5SN0A MN Erbb2 tyrosine kinase receptor (HER2) DM5SN0A MT DTT DM5SN0A MA Inhibitor DM5SN0A RN Clinical pipeline report, company report or official report of Molecular Templates. DM5SN0A RU https://www.mtem.com/pipeline/mt-5111 DMG4QDT DI DMG4QDT DMG4QDT DN MUC-1 dendritic cancer vaccine DMG4QDT MI TTBHFYQ DMG4QDT MN Mucin-1 (MUC1) DMG4QDT MT DTT DMG4QDT RN Dendritic cell vaccine immunotherapy of cancer targeting MUC1 mucin. Int J Mol Med. 2003 Oct;12(4):493-502. DMG4QDT RU https://pubmed.ncbi.nlm.nih.gov/12964025 DMAGCHE DI DMAGCHE DMAGCHE DN Multi-envelope HIV vaccine DMAGCHE MI TTBYP1X DMAGCHE MN Human immunodeficiency virus Envelope glycoprotein gp120 (HIV gp120) DMAGCHE MT DTT DMAGCHE RN An assessment of the role of chimpanzees in AIDS vaccine research. Altern Lab Anim. 2008 Sep;36(4):381-428. DMAGCHE RU https://pubmed.ncbi.nlm.nih.gov/18826331 DMAGCHE DI DMAGCHE DMAGCHE DN Multi-envelope HIV vaccine DMAGCHE MI TTG90S6 DMAGCHE MN Human immunodeficiency virus Glycoprotein 41 (HIV gp41) DMAGCHE MT DTT DMAGCHE RN An assessment of the role of chimpanzees in AIDS vaccine research. Altern Lab Anim. 2008 Sep;36(4):381-428. DMAGCHE RU https://pubmed.ncbi.nlm.nih.gov/18826331 DM3JUXW DI DM3JUXW DM3JUXW DN MVA HER-2 AutoVac DM3JUXW MI TT6EO5L DM3JUXW MN Erbb2 tyrosine kinase receptor (HER2) DM3JUXW MT DTT DM3JUXW RN Active immunotherapy in HER2 overexpressing breast cancer: current status and future perspectives. Ann Oncol. 2013 Jul;24(7):1740-8. DM3JUXW RU https://pubmed.ncbi.nlm.nih.gov/23585514 DMFMW5C DI DMFMW5C DMFMW5C DN MVA-BN Breast DMFMW5C MI TTS78AZ DMFMW5C MN Prostate specific antigen (KLK3) DMFMW5C MT DTT DMFMW5C MA Antagonist DMFMW5C RN Exosome targeting of tumor antigens expressed by cancer vaccines can improve antigen immunogenicity and therapeutic efficacy. Cancer Res. 2011 Aug 1;71(15):5235-44. DMFMW5C RU https://pubmed.ncbi.nlm.nih.gov/21670078 DM1FUAR DI DM1FUAR DM1FUAR DN MV-CEA DM1FUAR MI TTY6DTE DM1FUAR MN Carcinoembryonic antigen CEA (CD66e) DM1FUAR MT DTT DM1FUAR MA Modulator DM1FUAR RN Phase I trial of intraperitoneal administration of an oncolytic measles virus strain engineered to express carcinoembryonic antigen for recurrent ovarian cancer. Cancer Res. 2010 Feb 1;70(3):875-82. DM1FUAR RU https://pubmed.ncbi.nlm.nih.gov/20103634 DMEJ4C1 DI DMEJ4C1 DMEJ4C1 DN MVT-5873 DMEJ4C1 MI TT80ARU DMEJ4C1 MN Ganglioside GD2 (GD2) DMEJ4C1 MT DTT DMEJ4C1 MA Modulator DMEJ4C1 RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMEJ4C1 RU http://phrma-docs.phrma.org/files/dmfile/MID_Immuno-Oncology-2017_Drug-List1.pdf DM5O4X9 DI DM5O4X9 DM5O4X9 DN Mycophenolic acid glucuronide DM5O4X9 MI DTI7UX6 DM5O4X9 MN Breast cancer resistance protein (ABCG2) DM5O4X9 MT DTP DM5O4X9 MA Substrate DM5O4X9 RN Influence of drug transporters and UGT polymorphisms on pharmacokinetics of phenolic glucuronide metabolite of mycophenolic acid in Japanese renal transplant recipients. Ther Drug Monit. 2008 Oct;30(5):559-64. DM5O4X9 RU http://www.ncbi.nlm.nih.gov/pubmed/18695635 DMHO6XP DI DMHO6XP DMHO6XP DN MyoDys DMHO6XP MI TT48MP6 DMHO6XP MN Dystrophin (DMD) DMHO6XP MT DTT DMHO6XP MA Modulator DMHO6XP RN Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800009280) DMHO6XP RU http://adisinsight.springer.com/drugs/800009280 DM4ZN8M DI DM4ZN8M DM4ZN8M DN N-803 DM4ZN8M MI TTJFA35 DM4ZN8M MN Interleukin-15 (IL15) DM4ZN8M MT DTT DM4ZN8M MA Agonist DM4ZN8M RN The human IL-15 superagonist N-803 promotes migration of virus-specific CD8+ T and NK cells to B cell follicles but does not reverse latency in ART-suppressed, SHIV-infected macaques. PLoS Pathog. 2020 Mar 12;16(3):e1008339. DM4ZN8M RU https://pubmed.ncbi.nlm.nih.gov/32163523 DM3PC0J DI DM3PC0J DM3PC0J DN N-8295 DM3PC0J MI TTSHG0T DM3PC0J MN Toll-like receptor 9 (TLR9) DM3PC0J MT DTT DM3PC0J RN Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800019871) DM3PC0J RU http://adisinsight.springer.com/drugs/800019871 DM3IT6R DI DM3IT6R DM3IT6R DN N9-GP DM3IT6R MI TTFEZ5Q DM3IT6R MN Coagulation factor IX (F9) DM3IT6R MT DTT DM3IT6R MA Modulator DM3IT6R RN Enhanced pharmacokinetic properties of a glycoPEGylated recombinant factor IX: a first human dose trial in patients with hemophilia B. Blood. 2011 Sep 8;118(10):2695-701. DM3IT6R RU https://pubmed.ncbi.nlm.nih.gov/21555744 DM3E20L DI DM3E20L DM3E20L DN Nagrestipen DM3E20L MI TT8I4WB DM3E20L MN Macrophage inflammatory protein 1-alpha (CCL3) DM3E20L MT DTT DM3E20L MA Modulator DM3E20L RN Macrophage inflammatory protein derivative ECI301 enhances the alarmin-associated abscopal benefits of tumor radiotherapy. Cancer Res. 2014 Sep 15;74(18):5070-8. DM3E20L RU https://pubmed.ncbi.nlm.nih.gov/25038226 DMMKZYV DI DMMKZYV DMMKZYV DN Namitecan DMMKZYV MI TTGTQHC DMMKZYV MN DNA topoisomerase I (TOP1) DMMKZYV MT DTT DMMKZYV MA Inhibitor DMMKZYV RN Namitecan: a hydrophilic camptothecin with a promising preclinical profile. Curr Med Chem. 2012;19(21):3488-501. DMMKZYV RU https://pubmed.ncbi.nlm.nih.gov/22680917 DMHAZLM DI DMHAZLM DMHAZLM DN Naringenin DMHAZLM MI TTSZLWK DMHAZLM MN Aromatase (CYP19A1) DMHAZLM MT DTT DMHAZLM MA Inhibitor DMHAZLM RN Pharmacophore modeling strategies for the development of novel nonsteroidal inhibitors of human aromatase (CYP19). Bioorg Med Chem Lett. 2010 May 15;20(10):3050-64. DMHAZLM RU https://pubmed.ncbi.nlm.nih.gov/20413308 DMHAZLM DI DMHAZLM DMHAZLM DN Naringenin DMHAZLM MI DECV2ME DMHAZLM MN Cytochrome P450 105D7 (cyp105) DMHAZLM MT DME DMHAZLM MA Metabolism DMHAZLM RN The metagenome of Caracolus marginella gut microbiome using culture independent approaches and shotgun sequencing. Data Brief. 2017 Nov 22;16:501-505. DMHAZLM RU https://pubmed.ncbi.nlm.nih.gov/29270447 DMHAZLM DI DMHAZLM DMHAZLM DN Naringenin DMHAZLM MI TTI84H7 DMHAZLM MN Cytochrome P450 1B1 (CYP1B1) DMHAZLM MT DTT DMHAZLM MA Inhibitor DMHAZLM RN Selective inhibition of methoxyflavonoids on human CYP1B1 activity. Bioorg Med Chem. 2010 Sep 1;18(17):6310-5. DMHAZLM RU https://pubmed.ncbi.nlm.nih.gov/20696580 DMHAZLM DI DMHAZLM DMHAZLM DN Naringenin DMHAZLM MI TTIWB6L DMHAZLM MN Estradiol 17 beta-dehydrogenase 1 (17-beta-HSD1) DMHAZLM MT DTT DMHAZLM MA Inhibitor DMHAZLM RN Discovery of nonsteroidal 17beta-hydroxysteroid dehydrogenase 1 inhibitors by pharmacophore-based screening of virtual compound libraries. J Med Chem. 2008 Jul 24;51(14):4188-99. DMHAZLM RU https://pubmed.ncbi.nlm.nih.gov/18533708 DMHAZLM DI DMHAZLM DMHAZLM DN Naringenin DMHAZLM MI TTOM3J0 DMHAZLM MN Estrogen receptor beta (ESR2) DMHAZLM MT DTT DMHAZLM MA Inhibitor DMHAZLM RN Subtle side-chain modifications of the hop phytoestrogen 8-prenylnaringenin result in distinct agonist/antagonist activity profiles for estrogen re... J Med Chem. 2006 Dec 14;49(25):7357-65. DMHAZLM RU https://pubmed.ncbi.nlm.nih.gov/17149865 DMHAZLM DI DMHAZLM DMHAZLM DN Naringenin DMHAZLM MI TTV9A7R DMHAZLM MN Lactoylglutathione lyase (GLO1) DMHAZLM MT DTT DMHAZLM MA Inhibitor DMHAZLM RN Structure-activity relationship of human GLO I inhibitory natural flavonoids and their growth inhibitory effects. Bioorg Med Chem. 2008 Apr 1;16(7):3969-75. DMHAZLM RU https://pubmed.ncbi.nlm.nih.gov/18258440 DMHAZLM DI DMHAZLM DMHAZLM DN Naringenin DMHAZLM MI DTUGYRD DMHAZLM MN P-glycoprotein 1 (ABCB1) DMHAZLM MT DTP DMHAZLM MA Substrate DMHAZLM RN Flavonoid permeability across an in situ model of the blood-brain barrier. Free Radic Biol Med. 2004 Mar 1;36(5):592-604. DMHAZLM RU https://doi.org/10.1016/j.freeradbiomed.2003.11.023 DMZ2G69 DI DMZ2G69 DMZ2G69 DN Navicixizumab DMZ2G69 MI TTV23LH DMZ2G69 MN Delta-like protein 4 (DLL4) DMZ2G69 MT DTT DMZ2G69 RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMZ2G69 RU http://phrma-docs.phrma.org/files/dmfile/MID_Immuno-Oncology-2017_Drug-List1.pdf DMZ2G69 DI DMZ2G69 DMZ2G69 DN Navicixizumab DMZ2G69 MI TTOHSBA DMZ2G69 MN Vascular endothelial growth factor A (VEGFA) DMZ2G69 MT DTT DMZ2G69 RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMZ2G69 RU http://phrma-docs.phrma.org/files/dmfile/MID_Immuno-Oncology-2017_Drug-List1.pdf DMG0SWE DI DMG0SWE DMG0SWE DN NBF-006 DMG0SWE MI TT48Z3K DMG0SWE MN GSTP1 messenger RNA (GSTP1 mRNA) DMG0SWE MT DTT DMG0SWE MA Inhibitor DMG0SWE RN Clinical pipeline report, company report or official report of Nitto Biopharma. DMG0SWE RU https://www.nittobiopharma.com/index.php DM5BQK3 DI DM5BQK3 DM5BQK3 DN NBI-34041 DM5BQK3 MI TTIY658 DM5BQK3 MN Corticotropin-releasing factor receptor 2 (CRHR2) DM5BQK3 MT DTT DM5BQK3 MA Antagonist DM5BQK3 RN Emerging drugs for eating disorder treatment. Expert Opin Emerg Drugs. 2006 May;11(2):315-36. DM5BQK3 RU https://pubmed.ncbi.nlm.nih.gov/16634704 DM5OWXA DI DM5OWXA DM5OWXA DN NBM-BMX DM5OWXA MI TTT6LFV DM5OWXA MN Histone deacetylase 8 (HDAC8) DM5OWXA MT DTT DM5OWXA MA Inhibitor DM5OWXA RN Clinical pipeline report, company report or official report of NatureWise Biotech & Medicals. DM5OWXA RU https://www.naturewise.com.tw/#_index2 DMPHZI5 DI DMPHZI5 DMPHZI5 DN NBQX DMPHZI5 MI TTAN6JD DMPHZI5 MN Glutamate receptor AMPA (GRIA) DMPHZI5 MT DTT DMPHZI5 MA Inhibitor DMPHZI5 RN Synthesis and pharmacological characterization of N3-substituted willardiine derivatives: role of the substituent at the 5-position of the uracil r... J Med Chem. 2007 Apr 5;50(7):1558-70. DMPHZI5 RU https://pubmed.ncbi.nlm.nih.gov/17348638 DMPHZI5 DI DMPHZI5 DMPHZI5 DN NBQX DMPHZI5 MI TTVPQTF DMPHZI5 MN Glutamate receptor AMPA 1 (GRIA1) DMPHZI5 MT DTT DMPHZI5 MA Inhibitor DMPHZI5 RN Structural investigation of the 7-chloro-3-hydroxy-1H-quinazoline-2,4-dione scaffold to obtain AMPA and kainate receptor selective antagonists. Syn... J Med Chem. 2006 Oct 5;49(20):6015-26. DMPHZI5 RU https://pubmed.ncbi.nlm.nih.gov/17004715 DMPHZI5 DI DMPHZI5 DMPHZI5 DN NBQX DMPHZI5 MI TT0MYE2 DMPHZI5 MN Glutamate receptor ionotropic kainate 1 (GRIK1) DMPHZI5 MT DTT DMPHZI5 MA Inhibitor DMPHZI5 RN 4,10-Dihydro-4-oxo-4H-imidazo[1,2-a]indeno[1,2-e]pyrazin-2-carboxylic acid derivatives: highly potent and selective AMPA receptors antagonists with... Bioorg Med Chem Lett. 2000 May 15;10(10):1133-7. DMPHZI5 RU https://pubmed.ncbi.nlm.nih.gov/10843235 DMPHZI5 DI DMPHZI5 DMPHZI5 DN NBQX DMPHZI5 MI TTLD29N DMPHZI5 MN Glutamate receptor ionotropic NMDA 1 (NMDAR1) DMPHZI5 MT DTT DMPHZI5 MA Inhibitor DMPHZI5 RN Synthesis, ionotropic glutamate receptor binding affinity, and structure-activity relationships of a new set of 4,5-dihydro-8-heteroaryl-4-oxo-1,2,... J Med Chem. 2001 Sep 13;44(19):3157-65. DMPHZI5 RU https://pubmed.ncbi.nlm.nih.gov/11543685 DMPHZI5 DI DMPHZI5 DMPHZI5 DN NBQX DMPHZI5 MI TTKJEMQ DMPHZI5 MN Glutamate receptor ionotropic NMDA 2A (NMDAR2A) DMPHZI5 MT DTT DMPHZI5 MA Inhibitor DMPHZI5 RN Synthesis, ionotropic glutamate receptor binding affinity, and structure-activity relationships of a new set of 4,5-dihydro-8-heteroaryl-4-oxo-1,2,... J Med Chem. 2001 Sep 13;44(19):3157-65. DMPHZI5 RU https://pubmed.ncbi.nlm.nih.gov/11543685 DMPHZI5 DI DMPHZI5 DMPHZI5 DN NBQX DMPHZI5 MI TTN9D8E DMPHZI5 MN Glutamate receptor ionotropic NMDA 2B (NMDAR2B) DMPHZI5 MT DTT DMPHZI5 MA Inhibitor DMPHZI5 RN Synthesis, ionotropic glutamate receptor binding affinity, and structure-activity relationships of a new set of 4,5-dihydro-8-heteroaryl-4-oxo-1,2,... J Med Chem. 2001 Sep 13;44(19):3157-65. DMPHZI5 RU https://pubmed.ncbi.nlm.nih.gov/11543685 DMF3MN1 DI DMF3MN1 DMF3MN1 DN NBXT-001+Nobilis inhalation device DMF3MN1 MI TT9IK2Z DMF3MN1 MN N-methyl-D-aspartate receptor (NMDAR) DMF3MN1 MT DTT DMF3MN1 MA Antagonist DMF3MN1 RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMF3MN1 RU http://phrma-docs.phrma.org/files/dmfile/MID-Update_Alzheimers-Disease_2017-Drug-List.pdf DMM2SNG DI DMM2SNG DMM2SNG DN NC-4016 DMM2SNG MI TTUTN1I DMM2SNG MN Human Deoxyribonucleic acid (hDNA) DMM2SNG MT DTT DMM2SNG MA Inhibitor DMM2SNG RN Effects of Treatment with Platinum Azidothymidine and Azidothymidine on Telomerase Activity and Bcl-2 Concentration in Hepatocellular Carcinoma- Induced Rats. Avicenna J Med Biotechnol. 2014 Oct-Dec;6(4): 200-209. DMM2SNG RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4224659/ DMUSPW5 DI DMUSPW5 DMUSPW5 DN NCO-48 DMUSPW5 MI TTT4SY6 DMUSPW5 MN Hepatitis B virus Polymerase (HBV P) DMUSPW5 MT DTT DMUSPW5 MA Inhibitor DMUSPW5 RN Safety, Tolerability and Pharmacokinetics of NCO-48 Fumarate in Healthy Subjects DMUSPW5 RU https://clinicaltrials.gov/ct2/show/NCT04309526 DMKJRQS DI DMKJRQS DMKJRQS DN NCX-1015 DMKJRQS MI TTYRL6O DMKJRQS MN Glucocorticoid receptor (NR3C1) DMKJRQS MT DTT DMKJRQS MA Modulator DMKJRQS RN Glucocorticoid receptor nitration leads to enhanced anti-inflammatory effects of novel steroid ligands. J Immunol. 2003 Sep 15;171(6):3245-52. DMKJRQS RU https://pubmed.ncbi.nlm.nih.gov/12960354 DMM7RC5 DI DMM7RC5 DMM7RC5 DN NCX-6560 DMM7RC5 MI TTPADOQ DMM7RC5 MN HMG-CoA reductase (HMGCR) DMM7RC5 MT DTT DMM7RC5 MA Inhibitor DMM7RC5 RN Lovastatin and beyond: the history of the HMG-CoA reductase inhibitors. Nat Rev Drug Discov. 2003 Jul;2(7):517-26. DMM7RC5 RU https://pubmed.ncbi.nlm.nih.gov/12815379 DMVQAEK DI DMVQAEK DMVQAEK DN ND-1.1 DMVQAEK MI TTF4CAM DMVQAEK MN Influenza Hemagglutinin (Influ HA) DMVQAEK MT DTT DMVQAEK RN An adenovirus-based vaccine with a double-stranded RNA adjuvant protects mice and ferrets against H5N1 avian influenza in oral delivery models. Clin Vaccine Immunol. 2013 Jan;20(1):85-94. DMVQAEK RU https://pubmed.ncbi.nlm.nih.gov/23155123 DMUBTC6 DI DMUBTC6 DMUBTC6 DN ND7001 DMUBTC6 MI TTJGW1Z DMUBTC6 MN Phosphodiesterase 2A (PDE2A) DMUBTC6 MT DTT DMUBTC6 MA Modulator DMUBTC6 RN Phosphodiesterase 2 inhibitors promote axonal outgrowth in organotypic slice co-cultures. Neurosignals. 2013;21(3-4):197-212. DMUBTC6 RU https://pubmed.ncbi.nlm.nih.gov/22947663 DM830EN DI DM830EN DM830EN DN NEO-201 DM830EN MI TTA9CK4 DM830EN MN Biliary glycoprotein 1 (CEACAM1) DM830EN MT DTT DM830EN MA Inhibitor DM830EN RN The Monoclonal Antibody NEO-201 Enhances Natural Killer Cell Cytotoxicity Against Tumor Cells Through Blockade of the Inhibitory CEACAM5/CEACAM1 Immune Checkpoint Pathway. Cancer Biother Radiopharm. 2020 Apr;35(3):190-198. DM830EN RU https://pubmed.ncbi.nlm.nih.gov/31928422 DM830EN DI DM830EN DM830EN DN NEO-201 DM830EN MI TTY6DTE DM830EN MN Carcinoembryonic antigen CEA (CD66e) DM830EN MT DTT DM830EN MA Inhibitor DM830EN RN The Monoclonal Antibody NEO-201 Enhances Natural Killer Cell Cytotoxicity Against Tumor Cells Through Blockade of the Inhibitory CEACAM5/CEACAM1 Immune Checkpoint Pathway. Cancer Biother Radiopharm. 2020 Apr;35(3):190-198. DM830EN RU https://pubmed.ncbi.nlm.nih.gov/31928422 DMXTYWJ DI DMXTYWJ DMXTYWJ DN Neovastat DMXTYWJ MI TTXZ0KQ DMXTYWJ MN Matrix metalloproteinase-12 (MMP-12) DMXTYWJ MT DTT DMXTYWJ MA Inhibitor DMXTYWJ RN Neovastat, a naturally occurring multifunctional antiangiogenic drug, in phase III clinical trials. Semin Oncol. 2001 Dec;28(6):620-5. DMXTYWJ RU https://pubmed.ncbi.nlm.nih.gov/11740820 DMXTYWJ DI DMXTYWJ DMXTYWJ DN Neovastat DMXTYWJ MI TTLM12X DMXTYWJ MN Matrix metalloproteinase-2 (MMP-2) DMXTYWJ MT DTT DMXTYWJ MA Inhibitor DMXTYWJ RN Neovastat, a naturally occurring multifunctional antiangiogenic drug, in phase III clinical trials. Semin Oncol. 2001 Dec;28(6):620-5. DMXTYWJ RU https://pubmed.ncbi.nlm.nih.gov/11740820 DMXTYWJ DI DMXTYWJ DMXTYWJ DN Neovastat DMXTYWJ MI TT6X50U DMXTYWJ MN Matrix metalloproteinase-9 (MMP-9) DMXTYWJ MT DTT DMXTYWJ MA Inhibitor DMXTYWJ RN Neovastat, a naturally occurring multifunctional antiangiogenic drug, in phase III clinical trials. Semin Oncol. 2001 Dec;28(6):620-5. DMXTYWJ RU https://pubmed.ncbi.nlm.nih.gov/11740820 DM59ZDN DI DM59ZDN DM59ZDN DN Nesvacumab DM59ZDN MI TTKLQTJ DM59ZDN MN Angiopoietin-2 (ANGPT2) DM59ZDN MT DTT DM59ZDN MA Inhibitor DM59ZDN RN Tie-2/Angiopoietin pathway modulation as a therapeutic strategy for retinal disease. Expert Opin Investig Drugs. 2019 Oct;28(10):861-869. DM59ZDN RU https://pubmed.ncbi.nlm.nih.gov/31513439 DMNJTLC DI DMNJTLC DMNJTLC DN Neu-2000 DMNJTLC MI TTN9D8E DMNJTLC MN Glutamate receptor ionotropic NMDA 2B (NMDAR2B) DMNJTLC MT DTT DMNJTLC MA Antagonist DMNJTLC RN Neu2000, an NR2B-selective, moderate NMDA receptor antagonist and potent spin trapping molecule for stroke. Drug News Perspect. 2010 Nov;23(9):549-56. DMNJTLC RU https://pubmed.ncbi.nlm.nih.gov/21152450 DMQK5ET DI DMQK5ET DMQK5ET DN NG-350A DMQK5ET MI TTN6Y9A DMQK5ET MN CD40L receptor (CD40) DMQK5ET MT DTT DMQK5ET MA Agonist DMQK5ET RN Clinical pipeline report, company report or official report of PsiOxus Therapeutics. DMQK5ET RU https://psioxus.com/technology-products/ng-350a/ DMITVHM DI DMITVHM DMITVHM DN NG-641 DMITVHM MI TTQOVYA DMITVHM MN C-X-C motif chemokine 10 (CXCL10) DMITVHM MT DTT DMITVHM RN Clinical pipeline report, company report or official report of PsiOxus Therapeutics. DMITVHM RU https://psioxus.com/technology-products/ng-641/ DMITVHM DI DMITVHM DMITVHM DN NG-641 DMITVHM MI TTWE5PB DMITVHM MN C-X-C motif chemokine 9 (CXCL9) DMITVHM MT DTT DMITVHM RN Clinical pipeline report, company report or official report of PsiOxus Therapeutics. DMITVHM RU https://psioxus.com/technology-products/ng-641/ DMITVHM DI DMITVHM DMITVHM DN NG-641 DMITVHM MI TT95SOA DMITVHM MN Interferon alpha (IFNA) DMITVHM MT DTT DMITVHM RN Clinical pipeline report, company report or official report of PsiOxus Therapeutics. DMITVHM RU https://psioxus.com/technology-products/ng-641/ DMITVHM DI DMITVHM DMITVHM DN NG-641 DMITVHM MI TTGPQ0F DMITVHM MN Prolyl endopeptidase FAP (FAP) DMITVHM MT DTT DMITVHM RN Clinical pipeline report, company report or official report of PsiOxus Therapeutics. DMITVHM RU https://psioxus.com/technology-products/ng-641/ DMM1Y8F DI DMM1Y8F DMM1Y8F DN NGD 94-1 DMM1Y8F MI TTE0A2F DMM1Y8F MN Dopamine D4 receptor (D4R) DMM1Y8F MT DTT DMM1Y8F MA Antagonist DMM1Y8F RN The pipeline and future of drug development in schizophrenia. Mol Psychiatry. 2007 Oct;12(10):904-22. DMM1Y8F RU https://pubmed.ncbi.nlm.nih.gov/17667958 DMM1Y8F DI DMM1Y8F DMM1Y8F DN NGD 94-1 DMM1Y8F MI TT729IR DMM1Y8F MN Voltage-gated calcium channel alpha Cav3.1 (CACNA1G) DMM1Y8F MT DTT DMM1Y8F MA Blocker DMM1Y8F RN Differential inhibition of T-type calcium channels by neuroleptics. J Neurosci. 2002 Jan 15;22(2):396-403. DMM1Y8F RU https://pubmed.ncbi.nlm.nih.gov/11784784 DMF21XQ DI DMF21XQ DMF21XQ DN NGM120 DMF21XQ MI TTE61UB DMF21XQ MN GDNF family receptor alpha-like (GFRAL) DMF21XQ MT DTT DMF21XQ MA Antagonist DMF21XQ RN Clinical pipeline report, company report or official report of NGM Biopharmaceuticals. DMF21XQ RU https://www.ngmbio.com/pipeline/ DMYNSRH DI DMYNSRH DMYNSRH DN NGM313 DMYNSRH MI TTARBVH DMYNSRH MN Beta-klotho (KLB) DMYNSRH MT DTT DMYNSRH MA Modulator DMYNSRH RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMYNSRH RU http://phrma-docs.phrma.org/files/dmfile/mid-diabetes-drug-list.pdf DMYNSRH DI DMYNSRH DMYNSRH DN NGM313 DMYNSRH MI TTRLW2X DMYNSRH MN Fibroblast growth factor receptor 1 (FGFR1) DMYNSRH MT DTT DMYNSRH MA Modulator DMYNSRH RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMYNSRH RU http://phrma-docs.phrma.org/files/dmfile/mid-diabetes-drug-list.pdf DMTVQH2 DI DMTVQH2 DMTVQH2 DN NGP 555 DMTVQH2 MI TT9W8GU DMTVQH2 MN Gamma-secretase (GS) DMTVQH2 MT DTT DMTVQH2 MA Modulator DMTVQH2 RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMTVQH2 RU http://phrma-docs.phrma.org/files/dmfile/MID-Update_Alzheimers-Disease_2017-Drug-List.pdf DMU6CQ7 DI DMU6CQ7 DMU6CQ7 DN NHS-IL 12 DMU6CQ7 MI TTGW72V DMU6CQ7 MN Interleukin-12 beta (IL12B) DMU6CQ7 MT DTT DMU6CQ7 MA Modulator DMU6CQ7 RN The immunocytokine NHS-IL12 as a potential cancer therapeutic. Oncotarget. 2014 Apr 15;5(7):1869-84. DMU6CQ7 RU https://pubmed.ncbi.nlm.nih.gov/24681847 DM31FOP DI DM31FOP DM31FOP DN NI-0101 DM31FOP MI TTISGCA DM31FOP MN Toll-like receptor 4 (TLR4) DM31FOP MT DTT DM31FOP RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1754). DM31FOP RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1754 DM32VKQ DI DM32VKQ DM32VKQ DN NI-0701 DM32VKQ MI TT9DWLC DM32VKQ MN T-cell-specific protein RANTES (CCL5) DM32VKQ MT DTT DM32VKQ MA Inhibitor DM32VKQ RN Handbook of Therapeutic Antibodies. Stefan D bel, Janice M. Reichert, 2014. Page(1021). DM32VKQ RU https://books.google.com.hk/books?id=svHsBQAAQBAJ&pg=PA1021&lpg=PA1021&dq=%E2%80%9CNI-0701%E2%80%9D++RANTES&source=bl&ots=OSgek1U9gk&sig=gMuc7gZ8ZO4IH9EIdhuDhOrHTaU&hl=zh-CN&sa=X&ved=0CC8Q6AEwA2oVChMItuDj3InGyAIVzQmOCh0QPQ3H#v=onepage&q=%E2%80%9CNI-0701%E2%80%9D%20%20RANTES&f=false DM8J3WE DI DM8J3WE DM8J3WE DN Nibentan DM8J3WE MI TT1VOHK DM8J3WE MN Potassium channel unspecific (KC) DM8J3WE MT DTT DM8J3WE MA Blocker DM8J3WE RN Nibentan -- a drug for pharmacological cardioversion of persistent atrial fibrillation. Kardiologiia. 2005;45(3):19-23. DM8J3WE RU https://pubmed.ncbi.nlm.nih.gov/15821703 DMJBYSE DI DMJBYSE DMJBYSE DN Nicotinamide riboside DMJBYSE MI DEUATVX DMJBYSE MN Quinone reductase 2 (NQO2) DMJBYSE MT DME DMJBYSE MA Metabolism DMJBYSE RN Insights into the redox cycle of human quinone reductase 2. Free Radic Res. 2011 Oct;45(10):1184-95. DMJBYSE RU https://www.ncbi.nlm.nih.gov/pubmed/?term=21762045 DM0PYEQ DI DM0PYEQ DM0PYEQ DN NIP-004 DM0PYEQ MI TTIHYA4 DM0PYEQ MN Thrombopoietin receptor (MPL) DM0PYEQ MT DTT DM0PYEQ MA Agonist DM0PYEQ RN A novel nonpeptidyl human c-Mpl activator stimulates human megakaryopoiesis and thrombopoiesis. Blood. 2006 Jun 1;107(11):4300-7. DM0PYEQ RU https://pubmed.ncbi.nlm.nih.gov/16484588 DM4I02O DI DM4I02O DM4I02O DN NJA-730 DM4I02O MI TT1ERKL DM4I02O MN CD40 messenger RNA (CD40 mRNA) DM4I02O MT DTT DM4I02O MA Inhibitor DM4I02O RN Clinical pipeline report, company report or official report of NapaJen Pharma. DM4I02O RU https://www.napajen.com/en/study/nja-730/ DMSENTW DI DMSENTW DMSENTW DN NJH395 DMSENTW MI TT6EO5L DMSENTW MN Erbb2 tyrosine kinase receptor (HER2) DMSENTW MT DTT DMSENTW RN ClinicalTrials.gov (NCT03696771) Study to Determine Safety and Dose of NJH395 in Non-breast HER2+ Advanced Cancer. U.S. National Institutes of Health. DMSENTW RU https://clinicaltrials.gov/ct2/show/NCT03696771 DMGSDPL DI DMGSDPL DMGSDPL DN NK-314 DMGSDPL MI TT0IHXV DMGSDPL MN DNA topoisomerase II (TOP2) DMGSDPL MT DTT DMGSDPL MA Modulator DMGSDPL RN NK314, a topoisomerase II inhibitor that specifically targets the alpha isoform. J Biol Chem. 2008 Aug 29;283(35):23711-20. DMGSDPL RU https://pubmed.ncbi.nlm.nih.gov/18596031 DM5AWK1 DI DM5AWK1 DM5AWK1 DN NKP-1339 DM5AWK1 MI TTW26OG DM5AWK1 MN Endoplasmic reticulum chaperone BiP (HSPA5) DM5AWK1 MT DTT DM5AWK1 MA Inhibitor DM5AWK1 RN NKP-1339, a first-in-class anticancer drug showing mild side effects and activity in patients suffering from advanced refractory cancer. BMC Pharmacol Toxicol. 2012; 13(Suppl 1): A82. DM5AWK1 RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3506350/ DM5AWK1 DI DM5AWK1 DM5AWK1 DN NKP-1339 DM5AWK1 MI TT0K6EO DM5AWK1 MN Stress-activated protein kinase JNK1 (JNK1) DM5AWK1 MT DTT DM5AWK1 MA Inhibitor DM5AWK1 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1496). DM5AWK1 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1496 DMDLJM1 DI DMDLJM1 DMDLJM1 DN NKR-2 CAR-T Cells DMDLJM1 MI TTLRN4A DMDLJM1 MN NKG2 D activating NK receptor (KLRK1) DMDLJM1 MT DTT DMDLJM1 MA CAR-T-Cell-Therapy DMDLJM1 RN ClinicalTrials.gov (NCT03612739) EPITHINK: Epigenetic Drug Treatment and Therapeutic Immunotherapy With NKR-2 DMDLJM1 RU https://clinicaltrials.gov/ct2/show/NCT03612739 DMR5ATX DI DMR5ATX DMR5ATX DN NKR-2 cells DMR5ATX MI TTLRN4A DMR5ATX MN NKG2 D activating NK receptor (KLRK1) DMR5ATX MT DTT DMR5ATX MA CAR-T-Cell-Therapy DMR5ATX RN ClinicalTrials.gov (NCT03310008) Dose Escalation and Dose Expansion Phase I Study to Assess the Safety and Clinical Activity of Multiple Doses of NKR-2 Administered Concurrently With FOLFOX in Colorectal Cancer With Potentially Resectable Liver Metastases DMR5ATX RU https://clinicaltrials.gov/ct2/show/NCT03310008 DMI7ZK3 DI DMI7ZK3 DMI7ZK3 DN NKTT-120 DMI7ZK3 MI TTA6ZER DMI7ZK3 MN Immunoglobulin G1k (IgG1k) DMI7ZK3 MT DTT DMI7ZK3 RN Advances in Sickle Cell Therapies in the Hydroxyurea Era. Mol Med. 2014; 20(Suppl 1): S37-S42. DMI7ZK3 RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4374518/ DMP9J5V DI DMP9J5V DMP9J5V DN NLG802 DMP9J5V MI TTZJYKH DMP9J5V MN Indoleamine 2,3-dioxygenase 1 (IDO1) DMP9J5V MT DTT DMP9J5V MA Inhibitor DMP9J5V RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMP9J5V RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DMYPWHD DI DMYPWHD DMYPWHD DN NLG919 DMYPWHD MI TTV8N19 DMYPWHD MN Immune checkpoint (ICH) DMYPWHD MT DTT DMYPWHD MA Modulator DMYPWHD RN Deal watch: Genentech dives deeper into the next wave of cancer immunotherapies. Nat Rev Drug Discov. 2014 Dec;13(12):879. DMYPWHD RU https://pubmed.ncbi.nlm.nih.gov/25435209 DMPJMB7 DI DMPJMB7 DMPJMB7 DN NLX-101 DMPJMB7 MI TTSQIFT DMPJMB7 MN 5-HT 1A receptor (HTR1A) DMPJMB7 MT DTT DMPJMB7 MA Modulator DMPJMB7 RN In vivo electrophysiological and neurochemical effects of the selective 5-HT1A receptor agonist, F13640, at pre- and postsynaptic 5-HT1A receptors in the rat.Psychopharmacology (Berl).2012 May;221(2):261-72. DMPJMB7 RU https://www.ncbi.nlm.nih.gov/pubmed/22147258 DM5INE7 DI DM5INE7 DM5INE7 DN NM-3 DM5INE7 MI TT9HKJA DM5INE7 MN Vascular endothelial growth factor (VEGF) DM5INE7 MT DTT DM5INE7 MA Inhibitor DM5INE7 RN 2-(8-hydroxy-6-methoxy-1-oxo-1h-2-benzopyran-3-yl) propionic acid, an inhibitor of angiogenesis, ameliorates renal alterations in obese type 2 diabetic mice. Diabetes. 2006 May;55(5):1232-42. DM5INE7 RU https://pubmed.ncbi.nlm.nih.gov/16644677 DM2XIRW DI DM2XIRW DM2XIRW DN NMS-03305293 DM2XIRW MI TTVDSZ0 DM2XIRW MN Poly [ADP-ribose] polymerase 1 (PARP1) DM2XIRW MT DTT DM2XIRW MA Inhibitor DM2XIRW RN NMS-P293, a PARP-1 selective inhibitor with no trapping activity and high CNS penetration, possesses potent in vivo efficacy and represents a novel therapeutic option for brain localized metastases and glioblastoma. Cancer Res 2018;78(13 Suppl):Abstract nr 4843. DM2XIRW RU https://cancerres.aacrjournals.org/content/78/13_Supplement/4843 DMDGCHR DI DMDGCHR DMDGCHR DN NN-1218 DMDGCHR MI TTCBFJO DMDGCHR MN Insulin receptor (INSR) DMDGCHR MT DTT DMDGCHR MA Modulator DMDGCHR RN Ultrafast-Acting Insulins: State of the Art. J Diabetes Sci Technol. 2012 July; 6(4): 728-742. DMDGCHR RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3440142/ DMRJEXM DI DMRJEXM DMRJEXM DN NN-414 DMRJEXM MI TTP835K DMRJEXM MN ATP-binding cassette transporter C8 (ABCC8) DMRJEXM MT DTT DMRJEXM MA Modulator DMRJEXM RN Attenuation of hyperinsulinemia by NN414, a SUR1/Kir6.2 selective K-adenosine triphosphate channel opener, improves glucose tolerance and lipid profile in obese Zucker rats.Metabolism.2004 Apr;53(4):441-7. DMRJEXM RU https://www.ncbi.nlm.nih.gov/pubmed/15045689 DMHVIZC DI DMHVIZC DMHVIZC DN NN-7415 DMHVIZC MI TT068JH DMHVIZC MN Tissue factor pathway inhibitor (TFPI) DMHVIZC MT DTT DMHVIZC MA Modulator DMHVIZC RN Safety and pharmacokinetics of anti-TFPI antibody (concizumab) in healthy volunteers and patients with hemophilia: a randomized first human dose trial.J Thromb Haemost.2015 May;13(5):743-54. DMHVIZC RU https://www.ncbi.nlm.nih.gov/pubmed/25641556 DMYXDB9 DI DMYXDB9 DMYXDB9 DN NN-8828 DMYXDB9 MI TT9QEJ6 DMYXDB9 MN Interleukin-21 (IL21) DMYXDB9 MT DTT DMYXDB9 RN Handbook of Therapeutic Antibodies. 2014. 1. Page(995). DMYXDB9 RU https://books.google.com.hk/books?id=svHsBQAAQBAJ&pg=PA995&lpg=PA995&dq=NN-8828++++++ANTI&source=bl&ots=OSgek3Ucgf&sig=8iYcf4GKsCAvCCC1QHsKqxZK3YQ&hl=zh-CN&sa=X&ved=0CEwQ6AEwBmoVChMIyrS7qtXGyAIVA0COCh20lgxt#v=onepage&q=NN-8828%20%20%20%20%20%20ANTI&f=false DM1RBT8 DI DM1RBT8 DM1RBT8 DN NN-9926 DM1RBT8 MI TTVIMDE DM1RBT8 MN Glucagon-like peptide 1 receptor (GLP1R) DM1RBT8 MT DTT DM1RBT8 MA Agonist DM1RBT8 RN Clinical pipeline report, company report or official report of Addex Pharmaceuticals. DM1RBT8 RU https://www.google.com.hk/url?sa=t&rct=j&q=&esrc=s&source=web&cd=6&ved=0CEkQFjAFahUKEwiqkvGZp7nIAhWRBo4KHcHbD4U&url=http%3a%2f%2fwww%2eedisoninvestmentresearch%2ecom%2f%3fACT%3d18%26ID%3d6480&usg=AFQjCNHEg3ua1DahAa3uYwDK0pG0MPee7Q DMUPA7C DI DMUPA7C DMUPA7C DN NOCICEPTIN DMUPA7C MI TTNT7K8 DMUPA7C MN Nociceptin receptor (OPRL1) DMUPA7C MT DTT DMUPA7C MA Inhibitor DMUPA7C RN Binding and in vitro activities of peptides with high affinity for the nociceptin/orphanin FQ receptor, ORL1. J Pharmacol Exp Ther. 1997 Nov;283(2):735-41. DMUPA7C RU https://pubmed.ncbi.nlm.nih.gov/9353393 DMUPA7C DI DMUPA7C DMUPA7C DN NOCICEPTIN DMUPA7C MI TTKWM86 DMUPA7C MN Opioid receptor mu (MOP) DMUPA7C MT DTT DMUPA7C MA Inhibitor DMUPA7C RN Synthesis and pharmacological evaluation of 1,2-dihydrospiro[isoquinoline-4(3H),4'-piperidin]-3-ones as nociceptin receptor agonists. J Med Chem. 2008 Feb 28;51(4):1058-62. DMUPA7C RU https://pubmed.ncbi.nlm.nih.gov/18232652 DM2ILSJ DI DM2ILSJ DM2ILSJ DN Norbuprenorphine DM2ILSJ MI DTUGYRD DM2ILSJ MN P-glycoprotein 1 (ABCB1) DM2ILSJ MT DTP DM2ILSJ MA Substrate DM2ILSJ RN Interaction of drugs of abuse and maintenance treatments with human P-glycoprotein (ABCB1) and breast cancer resistance protein (ABCG2). Int J Neuropsychopharmacol. 2010 Aug;13(7):905-15. DM2ILSJ RU https://doi.org/10.1017/S1461145709990848 DME2QUZ DI DME2QUZ DME2QUZ DN NOV1501 DME2QUZ MI TTV23LH DME2QUZ MN Delta-like protein 4 (DLL4) DME2QUZ MT DTT DME2QUZ MA Inhibitor DME2QUZ RN Synergistic antitumor activity of a DLL4/VEGF bispecific therapeutic antibody in combination with irinotecan in gastric cancer. BMB Rep. 2020 Nov;53(10):533-538. DME2QUZ RU https://pubmed.ncbi.nlm.nih.gov/32580836 DME2QUZ DI DME2QUZ DME2QUZ DN NOV1501 DME2QUZ MI TT9HKJA DME2QUZ MN Vascular endothelial growth factor (VEGF) DME2QUZ MT DTT DME2QUZ MA Inhibitor DME2QUZ RN Synergistic antitumor activity of a DLL4/VEGF bispecific therapeutic antibody in combination with irinotecan in gastric cancer. BMB Rep. 2020 Nov;53(10):533-538. DME2QUZ RU https://pubmed.ncbi.nlm.nih.gov/32580836 DMMYRHV DI DMMYRHV DMMYRHV DN NOX-700 DMMYRHV MI TTUO9SZ DMMYRHV MN Nitric oxide elimination (NOE) DMMYRHV MT DTT DMMYRHV MA Modulator DMMYRHV RN Inhibition of nitrosylation, nitration, lymphocyte proliferation, and gene expression in acute and delayed cardiac allograft rejection by an orally active dithiocarbamate. J Cardiovasc Pharmacol. 2004 Apr;43(4):522-30. DMMYRHV RU https://pubmed.ncbi.nlm.nih.gov/15085063 DMMKN4Q DI DMMKN4Q DMMKN4Q DN NOX-A12 DMMKN4Q MI TT4UGTF DMMKN4Q MN Stromal cell-derived factor 1 (CXCL12) DMMKN4Q MT DTT DMMKN4Q MA Inhibitor DMMKN4Q RN SDF-1/CXCR4/CXCR7 is pivotal for vascular smooth muscle cell proliferation and chronic allograft vasculopathy. Transpl Int. 2015 Dec;28(12):1426-35. DMMKN4Q RU https://pubmed.ncbi.nlm.nih.gov/26265085 DMHARE7 DI DMHARE7 DMHARE7 DN NP-500 DMHARE7 MI TTZOPHG DMHARE7 MN Insulin (INS) DMHARE7 MT DTT DMHARE7 MA Modulator DMHARE7 RN Napo Receives Commitments for a Private Placement of Common Shares and Enters into Binding Letter of Intent for Intellectual Property License. Napo. JANUARY 08, 2007 DMHARE7 RU http://www.prnewswire.com/news-releases/napo-receives-commitments-for-a-private-placement-of-common-shares-and-enters-into-binding-letter-of-intent-for-intellectual-property-license-53349492.html DMZ72BD DI DMZ72BD DMZ72BD DN NP-G2-044 DMZ72BD MI TTTRS9B DMZ72BD MN Fascin (FSCN1) DMZ72BD MT DTT DMZ72BD MA Inhibitor DMZ72BD RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMZ72BD RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DMFDBV5 DI DMFDBV5 DMFDBV5 DN NPT200-11 DMFDBV5 MI TT08OSU DMFDBV5 MN Synuclein alpha (SNCA) DMFDBV5 MT DTT DMFDBV5 MA Inhibitor DMFDBV5 RN The small molecule alpha-synuclein misfolding inhibitor, NPT200-11, produces multiple benefits in an animal model of Parkinson's disease. Sci Rep. 2018 Nov 1;8(1):16165. DMFDBV5 RU https://pubmed.ncbi.nlm.nih.gov/30385782 DMX8LY4 DI DMX8LY4 DMX8LY4 DN NS-8 DMX8LY4 MI TT1VOHK DMX8LY4 MN Potassium channel unspecific (KC) DMX8LY4 MT DTT DMX8LY4 MA Agonist DMX8LY4 RN Stimulation of large-conductance calcium-activated potassium channels inhibits neurogenic contraction of human bladder from patients with urinary symptoms and reverses acetic acid-induced bladder hyperactivity in rats. Eur J Pharmacol. 2014 Jul 15;735:68-76. DMX8LY4 RU https://pubmed.ncbi.nlm.nih.gov/24747752 DMRAX19 DI DMRAX19 DMRAX19 DN NSC-14983 DMRAX19 MI DEQ90PB DMRAX19 MN Dihydroorotase (pyrC) DMRAX19 MT DME DMRAX19 MA Metabolism DMRAX19 RN Enzyme elements involved in the interconversion of L-carbamylaspartate and L-dihydroorotate by dihydroorotase from Clostridium oroticum. Arch Biochem Biophys. 1985 Dec;243(2):447-53. DMRAX19 RU https://pubmed.ncbi.nlm.nih.gov/2867744 DM6093Y DI DM6093Y DM6093Y DN NSC-172130 DM6093Y MI DECB0K3 DM6093Y MN Cytochrome P450 2D6 (CYP2D6) DM6093Y MT DME DM6093Y MA Metabolism DM6093Y RN Tricyclic antidepressant pharmacology and therapeutic drug interactions updated. Br J Pharmacol. 2007 Jul;151(6):737-48. DM6093Y RU https://www.ncbi.nlm.nih.gov/pubmed/?term=17471183 DM96RD5 DI DM96RD5 DM96RD5 DN NSC-38348 DM96RD5 MI DEJGDUW DM96RD5 MN Cytochrome P450 1A2 (CYP1A2) DM96RD5 MT DME DM96RD5 MA Metabolism DM96RD5 RN PharmGKB summary: caffeine pathway. Pharmacogenet Genomics. 2012 May;22(5):389-95. DM96RD5 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=22293536 DMTYGWV DI DMTYGWV DMTYGWV DN NSC-639829 DMTYGWV MI TTYFKSZ DMTYGWV MN Tubulin beta (TUBB) DMTYGWV MT DTT DMTYGWV MA Modulator DMTYGWV RN Solubilization of NSC-639829. Int J Pharm. 2001 Aug 28;225(1-2):41-7. DMTYGWV RU https://pubmed.ncbi.nlm.nih.gov/11489553 DM5QHID DI DM5QHID DM5QHID DN NSD-788 DM5QHID MI TTEX6LM DM5QHID MN GABA(A) receptor gamma-3 (GABRG3) DM5QHID MT DTT DM5QHID MA Modulator DM5QHID RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 415). DM5QHID RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=415 DM1ITDN DI DM1ITDN DM1ITDN DN NsG-0202 DM1ITDN MI TTDN3LF DM1ITDN MN Nerve growth factor (NGF) DM1ITDN MT DTT DM1ITDN MA Modulator DM1ITDN RN Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41. DM1ITDN RU https://www.ncbi.nlm.nih.gov/pubmed/15950434 DMSWJ6D DI DMSWJ6D DMSWJ6D DN NU-206 DMSWJ6D MI TTI9HL4 DMSWJ6D MN Roof plate-specific spondin-1 (RSPO1) DMSWJ6D MT DTT DMSWJ6D MA Modulator DMSWJ6D RN R-spondin1 and FOXL2 act into two distinct cellular types during goat ovarian differentiation.BMC Dev Biol.2008 Apr 2;8:36. DMSWJ6D RU https://www.ncbi.nlm.nih.gov/pubmed/18384673 DMQ0F5P DI DMQ0F5P DMQ0F5P DN NUC-3373 DMQ0F5P MI TT5FOMZ DMQ0F5P MN Thymidylate synthase (TYMS) DMQ0F5P MT DTT DMQ0F5P MA Inhibitor DMQ0F5P RN Clinical pipeline report, company report or official report of NuCana. DMQ0F5P RU http://www.nucana.com/nuc3373.html DMNF09S DI DMNF09S DMNF09S DN NV-04 DMNF09S MI TTXPQW1 DMNF09S MN Hormone unspecific (HOM) DMNF09S MT DTT DMNF09S MA Modulator DMNF09S RN US patent application no. 2011,0201,626, 4,6-diaminopyrimidine stimulators of soluble guanylate cyclase. DMNF09S RU https://www.google.com/patents/US20110201626 DMLKS7W DI DMLKS7W DMLKS7W DN NV-5138 DMLKS7W MI TTX4GLS DMLKS7W MN Mammalian target of rapamycin complex 1 (mTORC1) DMLKS7W MT DTT DMLKS7W MA Activator DMLKS7W RN Sestrin modulator NV-5138 produces rapid antidepressant effects via direct mTORC1 activation. J Clin Invest. 2019 Apr 16;129(6):2542-2554. DMLKS7W RU https://pubmed.ncbi.nlm.nih.gov/30990795 DM0UOA9 DI DM0UOA9 DM0UOA9 DN NV-52 DM0UOA9 MI TTKNWZ4 DM0UOA9 MN Thromboxane-A synthase (TBXAS1) DM0UOA9 MT DTT DM0UOA9 MA Inhibitor DM0UOA9 RN Phase Ib single- and multiple-dose pharmacokinetic study of oral NV-52 in healthy volunteers. Drugs R D. 2008;9(3):159-66. DM0UOA9 RU https://pubmed.ncbi.nlm.nih.gov/18457468 DM0EKUQ DI DM0EKUQ DM0EKUQ DN NY-ESO-1 vaccine DM0EKUQ MI TTE5ITK DM0EKUQ MN Cancer/testis antigen 1 (NY-ESO-1) DM0EKUQ MT DTT DM0EKUQ RN Multiepitope CD8+ T cell response to a NY-ESO-1 peptide vaccine results in imprecise tumor targeting. J Clin Invest. 2002 December 15; 110(12): 1813-1822. DM0EKUQ RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC151653/ DMWN2FP DI DMWN2FP DMWN2FP DN NZV930 DMWN2FP MI TTK0O6Y DMWN2FP MN Ecto-5'-nucleotidase (CD73) DMWN2FP MT DTT DMWN2FP MA Inhibitor DMWN2FP RN Clinical pipeline report, company report or official report of Surface oncology. DMWN2FP RU https://www.surfaceoncology.com/pipeline/the-srf373-nzv930-program/ DMPLV9G DI DMPLV9G DMPLV9G DN OBP-801 DMPLV9G MI TTBH0VX DMPLV9G MN Histone deacetylase (HDAC) DMPLV9G MT DTT DMPLV9G MA Inhibitor DMPLV9G RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMPLV9G RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DMPLV9G DI DMPLV9G DMPLV9G DN OBP-801 DMPLV9G MI TT6R7JZ DMPLV9G MN Histone deacetylase 1 (HDAC1) DMPLV9G MT DTT DMPLV9G MA Inhibitor DMPLV9G RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2658). DMPLV9G RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2658 DMW4JRY DI DMW4JRY DMW4JRY DN OBT076 DMW4JRY MI TTG180Q DMW4JRY MN Lymphocyte antigen 75 (LY75) DMW4JRY MT DTT DMW4JRY RN MEN1309/OBT076, a First-In-Class Antibody-Drug Conjugate Targeting CD205 in Solid Tumors. Mol Cancer Ther. 2019 Sep;18(9):1533-1543. DMW4JRY RU https://pubmed.ncbi.nlm.nih.gov/31227646 DMOSRFZ DI DMOSRFZ DMOSRFZ DN OC-10X DMOSRFZ MI TT9K83W DMOSRFZ MN Tubulin receptor (TUBR) DMOSRFZ MT DTT DMOSRFZ MA Inhibitor DMOSRFZ RN ClinicalTrials.gov (NCT01869933) Phase I Study Assessing the Ocular and Systemic Safety and Tolerability of OC-10X. U.S. National Institutes of Health. DMOSRFZ RU https://clinicaltrials.gov/ct2/show/NCT01869933 DMZK1GW DI DMZK1GW DMZK1GW DN OG987SC DMZK1GW MI TTVIMDE DMZK1GW MN Glucagon-like peptide 1 receptor (GLP1R) DMZK1GW MT DTT DMZK1GW MA Modulator DMZK1GW RN Clinical pipeline report, company report or official report of Novo Nordisk A/S. DMZK1GW RU http://www.novonordisk.com/bin/getPDF.1866957.pdf DMH0D5M DI DMH0D5M DMH0D5M DN OI287GT DMH0D5M MI TTZOPHG DMH0D5M MN Insulin (INS) DMH0D5M MT DTT DMH0D5M MA Modulator DMH0D5M RN Company report (Novonordisk) DMH0D5M RU http://www.novonordisk.com/bin/getPDF.1698237.pdf DMERDMV DI DMERDMV DMERDMV DN OI362GT DMERDMV MI TTZOPHG DMERDMV MN Insulin (INS) DMERDMV MT DTT DMERDMV MA Modulator DMERDMV RN Novo Nordisk increased operating profit in local currencies by 15% in the first quarter of 2014 DMERDMV RU https://www.novonordisk.com/bin/getPDF.1781915.pdf DMSJWTE DI DMSJWTE DMSJWTE DN OKI 179 DMSJWTE MI TTBH0VX DMSJWTE MN Histone deacetylase (HDAC) DMSJWTE MT DTT DMSJWTE MA Inhibitor DMSJWTE RN Clinical pipeline report, company report or official report of OnKure Therapeutics. DMSJWTE RU http://onkuretherapeutics.com/pipeline/ DMLVNWO DI DMLVNWO DMLVNWO DN Oleclumab DMLVNWO MI TTK0O6Y DMLVNWO MN Ecto-5'-nucleotidase (CD73) DMLVNWO MT DTT DMLVNWO MA Inhibitor DMLVNWO RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMLVNWO RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DM2THBX DI DM2THBX DM2THBX DN OM-174 DM2THBX MI TTY7ZHS DM2THBX MN Toll-like receptor 2 (TLR2) DM2THBX MT DTT DM2THBX MA Modulator DM2THBX RN Phase I study of OM-174, a lipid A analogue, with assessment of immunological response, in patients with refractory solid tumors. BMC Cancer. 2013 Apr 2;13:172. DM2THBX RU https://pubmed.ncbi.nlm.nih.gov/23547558 DM2THBX DI DM2THBX DM2THBX DN OM-174 DM2THBX MI TTISGCA DM2THBX MN Toll-like receptor 4 (TLR4) DM2THBX MT DTT DM2THBX MA Modulator DM2THBX RN Phase I study of OM-174, a lipid A analogue, with assessment of immunological response, in patients with refractory solid tumors. BMC Cancer. 2013 Apr 2;13:172. DM2THBX RU https://pubmed.ncbi.nlm.nih.gov/23547558 DMWHZEG DI DMWHZEG DMWHZEG DN OMN-54 DMWHZEG MI TTPVYKI DMWHZEG MN Signal transduction unspecific (ST) DMWHZEG MT DTT DMWHZEG MA Inhibitor DMWHZEG RN Enhanced anticancer activity of a combination of docetaxel and Aneustat (OMN54) in a patient-derived, advanced prostate cancer tissue xenograft model. Mol Oncol. 2014 Mar;8(2):311-22. DMWHZEG RU https://pubmed.ncbi.nlm.nih.gov/24388358 DMTFU8Q DI DMTFU8Q DMTFU8Q DN OMP-131R10 DMTFU8Q MI TT7HJTF DMTFU8Q MN R-spondin-3 (RSPO3) DMTFU8Q MT DTT DMTFU8Q RN Targeting the Wnt signaling pathway through R-spondin 3 identifies an anti-fibrosis treatment strategy for multiple organs. PLoS One. 2020 Mar 11;15(3):e0229445. DMTFU8Q RU https://pubmed.ncbi.nlm.nih.gov/32160239 DMWK679 DI DMWK679 DMWK679 DN OMP-18R5 DMWK679 MI TTUQMO5 DMWK679 MN Frizzled-7 receptor (FZD7) DMWK679 MT DTT DMWK679 MA Inhibitor DMWK679 RN Wnt pathway inhibition via the targeting of Frizzled receptors results in decreased growth and tumorigenicity of human tumors. Proc Natl Acad Sci U S A. 2012 Jul 17;109(29):11717-22. DMWK679 RU https://pubmed.ncbi.nlm.nih.gov/22753465 DMX1D0S DI DMX1D0S DMX1D0S DN OMP-21M18 DMX1D0S MI TTV23LH DMX1D0S MN Delta-like protein 4 (DLL4) DMX1D0S MT DTT DMX1D0S MA Modulator DMX1D0S RN National Cancer Institute Drug Dictionary (drug id 614677). DMX1D0S RU http://www.cancer.gov/publications/dictionaries/cancer-drug?cdrid=614677 DMGWC86 DI DMGWC86 DMGWC86 DN OMP-52M51 DMGWC86 MI TTB1STW DMGWC86 MN Notch-1 receptor (NOTCH1) DMGWC86 MT DTT DMGWC86 RN National Cancer Institute Drug Dictionary (drug id 741867). DMGWC86 RU http://www.cancer.gov/publications/dictionaries/cancer-drug?cdrid=741867 DMO0JP1 DI DMO0JP1 DMO0JP1 DN OMS527 DMO0JP1 MI TT1APCZ DMO0JP1 MN Phosphodiesterase 7 (PDE7) DMO0JP1 MT DTT DMO0JP1 MA Inhibitor DMO0JP1 RN Clinical pipeline report, company report or official report of Omeros. DMO0JP1 RU https://www.omeros.com/pipeline/ DMWYEDX DI DMWYEDX DMWYEDX DN ON-01210.Na DMWYEDX MI TTGQUFK DMWYEDX MN PI3K/AKT/mTOR pathway (PAm pathway) DMWYEDX MT DTT DMWYEDX MA Inhibitor DMWYEDX RN ON01210.Na (Ex-RAD ) mitigates radiation damage through activation of the AKT pathway. PLoS One. 2013;8(3):e58355. DMWYEDX RU https://pubmed.ncbi.nlm.nih.gov/23505494 DM5VY23 DI DM5VY23 DM5VY23 DN ONC206 DM5VY23 MI TTEX248 DM5VY23 MN Dopamine D2 receptor (D2R) DM5VY23 MT DTT DM5VY23 MA Antagonist DM5VY23 RN ONC206, an Imipridone Derivative, Induces Cell Death Through Activation of the Integrated Stress Response in Serous Endometrial Cancer In Vitro. Front Oncol. 2020 Oct 20;10:577141. DM5VY23 RU https://pubmed.ncbi.nlm.nih.gov/33194693 DM8B40M DI DM8B40M DM8B40M DN ONC-392 DM8B40M MI TTI2S1D DM8B40M MN Cytotoxic T-lymphocyte protein 4 (CTLA-4) DM8B40M MT DTT DM8B40M MA Inhibitor DM8B40M RN Clinical pipeline report, company report or official report of OncoImmune. DM8B40M RU https://www.oncoc4.com/index.php/product-development/onc-392 DMC29LV DI DMC29LV DMC29LV DN ONO-4059 DMC29LV MI TTGM6VW DMC29LV MN Tyrosine-protein kinase BTK (ATK) DMC29LV MT DTT DMC29LV MA Modulator DMC29LV RN ONO-4059, a novel oral Bruton's tyrosine kinase (Btk) inhibitor that demonstrates potent pharmacodynamic activity through Phosphorylated Btk (P-Btk) inhibition, in addition to effective anti-tumour activity in a TMD-8 (DLBCL) xenograft model. Cancer Research. 08/2013; 73(8 Supplement):2452-2452. DMC29LV RU http://cancerres.aacrjournals.org/content/73/8_Supplement/2452 DMO4SD2 DI DMO4SD2 DMO4SD2 DN ONO-4232 DMO4SD2 MI TT79WV3 DMO4SD2 MN Prostaglandin E2 receptor EP4 (PTGER4) DMO4SD2 MT DTT DMO4SD2 MA Agonist DMO4SD2 RN ONO-4232, an EP4-selective Agonist, Improves Left Ventricular Diastolic Dysfunction and Ameliorates Acute and Chronic Heart Failure in Animal Models. Circulation. 2012; 126: A15345. DMO4SD2 RU http://circ.ahajournals.org/cgi/content/meeting_abstract/126/21_MeetingAbstracts/A15345 DME63VK DI DME63VK DME63VK DN ONO-4578 DME63VK MI TT79WV3 DME63VK MN Prostaglandin E2 receptor EP4 (PTGER4) DME63VK MT DTT DME63VK MA Antagonist DME63VK RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DME63VK RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DMGBKCJ DI DMGBKCJ DMGBKCJ DN ONO-7475 DMGBKCJ MI TTO7LKR DMGBKCJ MN Tyrosine-protein kinase Mer (MERTK) DMGBKCJ MT DTT DMGBKCJ MA Inhibitor DMGBKCJ RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMGBKCJ RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DMGBKCJ DI DMGBKCJ DMGBKCJ DN ONO-7475 DMGBKCJ MI TTZPY6J DMGBKCJ MN Tyrosine-protein kinase UFO (AXL) DMGBKCJ MT DTT DMGBKCJ MA Inhibitor DMGBKCJ RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMGBKCJ RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DMUZFVH DI DMUZFVH DMUZFVH DN ONT-10 DMUZFVH MI TTBHFYQ DMUZFVH MN Mucin-1 (MUC1) DMUZFVH MT DTT DMUZFVH RN Clinical pipeline report, company report or official report of Oncothyreon. DMUZFVH RU http://www.oncothyreon.com/product_pipeline/ont-10.html DMBVZND DI DMBVZND DMBVZND DN ONYX-015 DMBVZND MI TT7SBF5 DMBVZND MN Cellular tumor antigen p53 (TP53) DMBVZND MT DTT DMBVZND MA Modulator DMBVZND RN Late viral RNA export, rather than p53 inactivation, determines ONYX-015 tumor selectivity. Cancer Cell. 2004 Dec;6(6):611-23. DMBVZND RU https://pubmed.ncbi.nlm.nih.gov/15607965 DMECVP9 DI DMECVP9 DMECVP9 DN OP-0595 DMECVP9 MI TTHI19T DMECVP9 MN Staphylococcus Beta-lactamase (Stap-coc blaZ) DMECVP9 MT DTT DMECVP9 MA Inhibitor DMECVP9 RN OP0595, a new diazabicyclooctane: mode of action as a serine -lactamase inhibitor, antibiotic and -lactam 'enhancer'. J Antimicrob Chemother. 2015 Oct;70(10):2779-86. DMECVP9 RU https://pubmed.ncbi.nlm.nih.gov/26089439 DM7YFW5 DI DM7YFW5 DM7YFW5 DN OPB-111077 DM7YFW5 MI TTH8FZW DM7YFW5 MN Signal transducer and activator of transcription 3 (STAT3) DM7YFW5 MT DTT DM7YFW5 MA Inhibitor DM7YFW5 RN Phase I Dose-Finding Study of OPB-111077, a Novel STAT3 Inhibitor, in Patients with Advanced Hepatocellular Carcinoma. Cancer Res Treat. 2019 Apr;51(2):510-518. DM7YFW5 RU https://pubmed.ncbi.nlm.nih.gov/29898591 DM760FA DI DM760FA DM760FA DN OPB-51602 DM760FA MI TTH8FZW DM760FA MN Signal transducer and activator of transcription 3 (STAT3) DM760FA MT DTT DM760FA MA Inhibitor DM760FA RN Phase I and biomarker study of OPB-51602, a novel signal transducer and activator of transcription (STAT) 3 inhibitor, in patients with refractory solid malignancies. Ann Oncol. 2015 May;26(5):998-1005. DM760FA RU https://pubmed.ncbi.nlm.nih.gov/25609248 DMZWFKQ DI DMZWFKQ DMZWFKQ DN OPC-14117 DMZWFKQ MI TTAD7UL DMZWFKQ MN Superoxide anion (SPA) DMZWFKQ MT DTT DMZWFKQ MA Modulator DMZWFKQ RN Evaluation of superoxide scavenging activity of OPC-14117 by electron spin resonance technique. Free Radic Res Commun. 1991;15(4):223-30. DMZWFKQ RU https://pubmed.ncbi.nlm.nih.gov/1667773 DMLUYAJ DI DMLUYAJ DMLUYAJ DN OPK-0018 DMLUYAJ MI TT4QPUL DMLUYAJ MN Antithrombin-III (ATIII) DMLUYAJ MT DTT DMLUYAJ MA Antagonist DMLUYAJ RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2632). DMLUYAJ RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2632 DM3HOUX DI DM3HOUX DM3HOUX DN OPL-CCL2-LPM DM3HOUX MI TTFZYTO DM3HOUX MN C-C chemokine receptor type 2 (CCR2) DM3HOUX MT DTT DM3HOUX MA Modulator DM3HOUX RN Selective CCR2-targeted macrophage depletion ameliorates experimental mesangioproliferative glomerulonephritis. Clin Exp Immunol. 2009 February; 155(2): 295-303. DM3HOUX RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2675261/ DMH6SNO DI DMH6SNO DMH6SNO DN OP-R003 DMH6SNO MI TTT1V78 DMH6SNO MN Interleukin-6 (IL6) DMH6SNO MT DTT DMH6SNO MA Modulator DMH6SNO RN A high-affinity fully human anti-IL-6 mAb (OP-R003-1, 1339) for the treatment of Multiple Myeloma DMH6SNO RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2787636 DMBG534 DI DMBG534 DMBG534 DN Org-25435 DMBG534 MI TTEX6LM DMBG534 MN GABA(A) receptor gamma-3 (GABRG3) DMBG534 MT DTT DMBG534 MA Modulator DMBG534 RN First administration to man of Org 25435, an intravenous anaesthetic: A Phase 1 Clinical Trial. BMC Anesthesiol. 2010 Jun 29;10:10. DMBG534 RU https://pubmed.ncbi.nlm.nih.gov/20587019 DME0WX2 DI DME0WX2 DME0WX2 DN Org-43902 DME0WX2 MI TT2O4W9 DME0WX2 MN Luteinizing hormone receptor (LHCGR) DME0WX2 MT DTT DME0WX2 MA Agonist DME0WX2 RN First evidence of ovulation induced by oral LH agonists in healthy female volunteers of reproductive age. J Clin Endocrinol Metab. 2013 Apr;98(4):1558-66. DME0WX2 RU https://pubmed.ncbi.nlm.nih.gov/23515453 DMR12S0 DI DMR12S0 DMR12S0 DN ORIC-101 DMR12S0 MI TTOZRK6 DMR12S0 MN Glucocorticoid receptor messenger RNA (GCR mRNA) DMR12S0 MT DTT DMR12S0 MA Antagonist DMR12S0 RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMR12S0 RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DMS8NM5 DI DMS8NM5 DMS8NM5 DN OS2966 DMS8NM5 MI TTBVIQC DMS8NM5 MN Integrin beta-1 (ITGB1) DMS8NM5 MT DTT DMS8NM5 MA Inhibitor DMS8NM5 RN Convection-Enhanced Delivery of a First-in-Class Anti-beta1 Integrin Antibody for the Treatment of High-Grade Glioma Utilizing Real-Time Imaging. Pharmaceutics. 2020 Dec 30;13(1):40. DMS8NM5 RU https://pubmed.ncbi.nlm.nih.gov/33396712 DMF2CZ9 DI DMF2CZ9 DMF2CZ9 DN OSI-930 DMF2CZ9 MI TTX41N9 DMF2CZ9 MN Tyrosine-protein kinase Kit (KIT) DMF2CZ9 MT DTT DMF2CZ9 MA Modulator DMF2CZ9 RN OSI-930 analogues as novel reversal agents for ABCG2-mediated multidrug resistance. Biochem Pharmacol. 2012 Sep 15;84(6):766-74. DMF2CZ9 RU https://pubmed.ncbi.nlm.nih.gov/22750060 DMF2CZ9 DI DMF2CZ9 DMF2CZ9 DN OSI-930 DMF2CZ9 MI TTUTJGQ DMF2CZ9 MN Vascular endothelial growth factor receptor 2 (KDR) DMF2CZ9 MT DTT DMF2CZ9 MA Modulator DMF2CZ9 RN OSI-930 analogues as novel reversal agents for ABCG2-mediated multidrug resistance. Biochem Pharmacol. 2012 Sep 15;84(6):766-74. DMF2CZ9 RU https://pubmed.ncbi.nlm.nih.gov/22750060 DMI24RF DI DMI24RF DMI24RF DN OT-82 DMI24RF MI TTD1WIG DMI24RF MN Nicotinamide phosphoribosyltransferase (NAMPT) DMI24RF MT DTT DMI24RF MA Inhibitor DMI24RF RN OT-82, a novel anticancer drug candidate that targets the strong dependence of hematological malignancies on NAD biosynthesis. Leukemia. 2020 Jul;34(7):1828-1839. DMI24RF RU https://pubmed.ncbi.nlm.nih.gov/31896781 DMWIEC1 DI DMWIEC1 DMWIEC1 DN OTSA-101-DTPA-90Y DMWIEC1 MI TTP1S2F DMWIEC1 MN Frizzled-10 (FZD10) DMWIEC1 MT DTT DMWIEC1 RN A first-in-human study investigating biodistribution, safety and recommended dose of a new radiolabeled MAb targeting FZD10 in metastatic synovial sarcoma patients. BMC Cancer. 2018 Jun 8;18(1):646. DMWIEC1 RU https://pubmed.ncbi.nlm.nih.gov/29884132 DMF5KNO DI DMF5KNO DMF5KNO DN OTSSP167 DMF5KNO MI TT5MN2U DMF5KNO MN Maternal embryonic leucine zipper kinase (MELK) DMF5KNO MT DTT DMF5KNO MA Inhibitor DMF5KNO RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMF5KNO RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DMF5KNO DI DMF5KNO DMF5KNO DN OTSSP167 DMF5KNO MI TTBZOTY DMF5KNO MN Tyrosine-protein kinase MELK (MELK) DMF5KNO MT DTT DMF5KNO MA Inhibitor DMF5KNO RN Development of an orally-administrative MELK-targeting inhibitor that suppresses the growth of various types of human cancer. Oncotarget. 2012 Dec;3(12):1629-40. DMF5KNO RU https://pubmed.ncbi.nlm.nih.gov/23283305 DMN4LMT DI DMN4LMT DMN4LMT DN Oxeglitazar DMN4LMT MI TTJ584C DMN4LMT MN Peroxisome proliferator-activated receptor alpha (PPARA) DMN4LMT MT DTT DMN4LMT MA Modulator DMN4LMT RN Therapeutic potential of aleglitazar, a new dual PPAR-alpha/gamma agonist: implications for cardiovascular disease in patients with diabetes mellitus. Am J Cardiovasc Drugs. 2010;10(4):209-16. DMN4LMT RU https://pubmed.ncbi.nlm.nih.gov/20653327 DMN4LMT DI DMN4LMT DMN4LMT DN Oxeglitazar DMN4LMT MI TTZMAO3 DMN4LMT MN Peroxisome proliferator-activated receptor gamma (PPAR-gamma) DMN4LMT MT DTT DMN4LMT MA Modulator DMN4LMT RN Therapeutic potential of aleglitazar, a new dual PPAR-alpha/gamma agonist: implications for cardiovascular disease in patients with diabetes mellitus. Am J Cardiovasc Drugs. 2010;10(4):209-16. DMN4LMT RU https://pubmed.ncbi.nlm.nih.gov/20653327 DMXZOI0 DI DMXZOI0 DMXZOI0 DN P11187 DMXZOI0 MI TTB8FUC DMXZOI0 MN Free fatty acid receptor 1 (GPR40) DMXZOI0 MT DTT DMXZOI0 MA Modulator DMXZOI0 RN Treatment of Type 2 Diabetes by Free Fatty Acid Receptor Agonists. Front Endocrinol (Lausanne) 2014; 5: 137. DMXZOI0 RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4147718/ DMXHKYJ DI DMXHKYJ DMXHKYJ DN P1446A-05 DMXHKYJ MI TT0PG8F DMXHKYJ MN Cyclin-dependent kinase 4 (CDK4) DMXHKYJ MT DTT DMXHKYJ MA Inhibitor DMXHKYJ RN Cell cycle kinases as therapeutic targets for cancer. Nat Rev Drug Discov. 2009 Jul;8(7):547-66. DMXHKYJ RU https://pubmed.ncbi.nlm.nih.gov/19568282 DMJ3PNS DI DMJ3PNS DMJ3PNS DN P-2745 DMJ3PNS MI TTP4520 DMJ3PNS MN TGF-beta receptor type I (TGFBR1) DMJ3PNS MT DTT DMJ3PNS MA Modulator DMJ3PNS RN Novel potent inhibitor of Bcr-Abl mutated imatinib resistant chronic myeloid leukemia cell lines. Cancer Research. 06/2012; 72(8 Supplement):1822-1822. DMJ3PNS RU http://cancerres.aacrjournals.org/content/72/8_Supplement/1822.short DMIYQEM DI DMIYQEM DMIYQEM DN P-7170 DMIYQEM MI TTHBTOP DMIYQEM MN PI3-kinase gamma (PIK3CG) DMIYQEM MT DTT DMIYQEM MA Inhibitor DMIYQEM RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2155). DMIYQEM RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2155 DMNZQU5 DI DMNZQU5 DMNZQU5 DN P-7435 DMNZQU5 MI TTF8P9I DMNZQU5 MN Diacylglycerol acyltransferase 1 (DGAT1) DMNZQU5 MT DTT DMNZQU5 MA Inhibitor DMNZQU5 RN Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800033014) DMNZQU5 RU http://adisinsight.springer.com/drugs/800033014 DMYQUIP DI DMYQUIP DMYQUIP DN PAC1 DMYQUIP MI TTPF2QI DMYQUIP MN Caspase-3 (CASP3) DMYQUIP MT DTT DMYQUIP MA Activator DMYQUIP RN Small-molecule activation of procaspase-3 to caspase-3 as a personalized anticancer strategy. Nat Chem Biol. 2006 Oct;2(10):543-50. DMYQUIP RU https://pubmed.ncbi.nlm.nih.gov/16936720 DMX9AK6 DI DMX9AK6 DMX9AK6 DN PACAP38 DMX9AK6 MI TTW4LYC DMX9AK6 MN Pituitary adenylate cyclase-activating 38 (PACAP-38) DMX9AK6 MT DTT DMX9AK6 MA Modulator DMX9AK6 RN Pituitary adenylate cyclase-activating polypeptides, PACAP-38 and PACAP-27, regulation of sympathetic neuron catecholamine, and neuropeptide Y expr... Ann N Y Acad Sci. 1996 Dec 26;805:204-16; discussion 217-8. DMX9AK6 RU https://pubmed.ncbi.nlm.nih.gov/8993404 DMXQ4NO DI DMXQ4NO DMXQ4NO DN Palomid-529 DMXQ4NO MI TTX4GLS DMXQ4NO MN Mammalian target of rapamycin complex 1 (mTORC1) DMXQ4NO MT DTT DMXQ4NO MA Inhibitor DMXQ4NO RN Dual mTORC1 and mTORC2 inhibitor Palomid 529 penetrates the blood-brain barrier without restriction by ABCB1 and ABCG2. Int J Cancer. 2013 Sep 1;133(5):1222-33. DMXQ4NO RU https://pubmed.ncbi.nlm.nih.gov/23436212 DMXQ4NO DI DMXQ4NO DMXQ4NO DN Palomid-529 DMXQ4NO MI TTWDKCL DMXQ4NO MN Target of rapamycin complex 2 MAPKAP1 (MTORC2) DMXQ4NO MT DTT DMXQ4NO MA Inhibitor DMXQ4NO RN Dual mTORC1 and mTORC2 inhibitor Palomid 529 penetrates the blood-brain barrier without restriction by ABCB1 and ABCG2. Int J Cancer. 2013 Sep 1;133(5):1222-33. DMXQ4NO RU https://pubmed.ncbi.nlm.nih.gov/23436212 DMY9LG1 DI DMY9LG1 DMY9LG1 DN PAN-90806 DMY9LG1 MI TT9HKJA DMY9LG1 MN Vascular endothelial growth factor (VEGF) DMY9LG1 MT DTT DMY9LG1 MA Inhibitor DMY9LG1 RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMY9LG1 RU http://phrma-docs.phrma.org/files/dmfile/mid-diabetes-drug-list.pdf DMZSD3T DI DMZSD3T DMZSD3T DN Patient-derived CD19- and CD22 specific CAR DMZSD3T MI TTM6QSK DMZSD3T MN B-cell receptor CD22 (CD22) DMZSD3T MT DTT DMZSD3T MA CAR-T-Cell-Therapy(Dual specific) DMZSD3T RN ClinicalTrials.gov (NCT03330691) A Feasibility and Safety Study of Dual Specificity CD19 and CD22 CAR-T Cell Immunotherapy for CD19+CD22+ Leukemia and Lymphoma DMZSD3T RU https://clinicaltrials.gov/ct2/show/NCT03330691 DMZSD3T DI DMZSD3T DMZSD3T DN Patient-derived CD19- and CD22 specific CAR DMZSD3T MI TTW640A DMZSD3T MN B-lymphocyte surface antigen B4 (CD19) DMZSD3T MT DTT DMZSD3T MA CAR-T-Cell-Therapy(Dual specific) DMZSD3T RN ClinicalTrials.gov (NCT03330691) A Feasibility and Safety Study of Dual Specificity CD19 and CD22 CAR-T Cell Immunotherapy for CD19+CD22+ Leukemia and Lymphoma DMZSD3T RU https://clinicaltrials.gov/ct2/show/NCT03330691 DMFSMCB DI DMFSMCB DMFSMCB DN Patritumab DMFSMCB MI TTDC8N2 DMFSMCB MN Erbb3 tyrosine kinase receptor (Erbb-3) DMFSMCB MT DTT DMFSMCB RN Phase 1 and dose-finding study of patritumab (U3-1287), a human monoclonal antibody targeting HER3, in Japanese patients with advanced solid tumors. Cancer Chemother Pharmacol. 2014 Mar;73(3):511-6. DMFSMCB RU https://pubmed.ncbi.nlm.nih.gov/24442032 DMDC9TB DI DMDC9TB DMDC9TB DN P-BCMA-101 CAR-T cells DMDC9TB MI TTZ3P4W DMDC9TB MN B-cell maturation protein (TNFRSF17) DMDC9TB MT DTT DMDC9TB MA CAR-T-Cell-Therapy DMDC9TB RN ClinicalTrials.gov (NCT03288493) P-BCMA-101 Tscm CAR-T Cells in the Treatment of Patients With Multiple Myeloma (MM) DMDC9TB RU https://clinicaltrials.gov/ct2/show/NCT03288493 DMOPGXM DI DMOPGXM DMOPGXM DN PBF-1129 DMOPGXM MI TTNE7KG DMOPGXM MN Adenosine A2b receptor (ADORA2B) DMOPGXM MT DTT DMOPGXM MA Antagonist DMOPGXM RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMOPGXM RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DMBSQH9 DI DMBSQH9 DMBSQH9 DN PBF-999 DMBSQH9 MI TTM2AOE DMBSQH9 MN Adenosine A2a receptor (ADORA2A) DMBSQH9 MT DTT DMBSQH9 MA Antagonist DMBSQH9 RN Clinical pipeline report, company report or official report of Palobiofarma. DMBSQH9 RU https://www.palobiofarma.com/pipeline-2/ DMBSQH9 DI DMBSQH9 DMBSQH9 DN PBF-999 DMBSQH9 MI TTJW4LU DMBSQH9 MN Phosphodiesterase 10A (PDE10) DMBSQH9 MT DTT DMBSQH9 MA Inhibitor DMBSQH9 RN Clinical pipeline report, company report or official report of Palobiofarma. DMBSQH9 RU https://www.palobiofarma.com/pipeline-2/ DM0O2N4 DI DM0O2N4 DM0O2N4 DN pbi-shRNA EWS-FLI-Type 1 DM0O2N4 MI TTHOM2S DM0O2N4 MN EWS-FLI1 fusion gene mRNA (EWS-FLI1 mRNA) DM0O2N4 MT DTT DM0O2N4 MA Inhibitor DM0O2N4 RN National Cancer Institute Drug Dictionary (drug id 780967). DM0O2N4 RU https://www.cancer.gov/publications/dictionaries/cancer-drug/def/780967 DM529QO DI DM529QO DM529QO DN pbi-shRNA STMN1 DM529QO MI TT7W5OT DM529QO MN STMN1 messenger RNA (STMN1 mRNA) DM529QO MT DTT DM529QO MA Inhibitor DM529QO RN Clinical pipeline report, company report or official report of Gradalis. DM529QO RU https://www.gradalisinc.com/product/development-pipeline DMMR4E7 DI DMMR4E7 DMMR4E7 DN PBSVax DMMR4E7 MI TT3NH7G DMMR4E7 MN Human immunodeficiency virus Deoxyribonucleic acid (HIV DNA) DMMR4E7 MT DTT DMMR4E7 MA Modulator DMMR4E7 RN ClinicalTrials.gov (NCT01578889) Evaluating the Safety of and Immune Response to HIV-MAG DNA Vaccine With or Without Plasmid IL-12 Adjuvant Delivered Intramuscularly Via Electroporation Followed by VSV-gag HIV Vaccine Boost in Healthy, HIV-Uninfected Adults. U.S. National Institutes of Health. DMMR4E7 RU https://clinicaltrials.gov/ct2/show/NCT01578889 DM23K45 DI DM23K45 DM23K45 DN Pc4 DM23K45 MI TTJGNVC DM23K45 MN Apoptosis regulator Bcl-2 (BCL-2) DM23K45 MT DTT DM23K45 MA Agonist DM23K45 RN Association between the photodynamic loss of Bcl-2 and the sensitivity to apoptosis caused by phthalocyanine photodynamic therapy. Photochem Photobiol. 2003 Jul;78(1):1-8. DM23K45 RU https://pubmed.ncbi.nlm.nih.gov/12929741 DMNHSI8 DI DMNHSI8 DMNHSI8 DN PCO371 DMNHSI8 MI TTFPD47 DMNHSI8 MN Parathyroid hormone 1 receptor (PTH1R) DMNHSI8 MT DTT DMNHSI8 MA Agonist DMNHSI8 RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMNHSI8 RU http://phrma-docs.phrma.org/sites/default/files/pdf/medicines-in-development-drug-list-rare-diseases.pdf DMH86KO DI DMH86KO DMH86KO DN PCSK9 Adnectin DMH86KO MI TTBRG7E DMH86KO MN Proprotein convertase subtilisin/kexin type 9 (PCSK9) DMH86KO MT DTT DMH86KO MA Modulator DMH86KO RN Pharmacologic profile of the Adnectin BMS-962476, a small protein biologic alternative to PCSK9 antibodies for low-density lipoprotein lowering. J Pharmacol Exp Ther. 2014 Aug;350(2):412-24. DMH86KO RU https://pubmed.ncbi.nlm.nih.gov/24917546 DM74YO8 DI DM74YO8 DM74YO8 DN PDC-41 DM74YO8 MI TTT2ZAR DM74YO8 MN Prostaglandin F2-alpha receptor (PTGFR) DM74YO8 MT DTT DM74YO8 MA Antagonist DM74YO8 RN THG113: a novel selective FP antagonist that delays preterm labor. Semin Perinatol. 2002 Dec;26(6):389-97. DM74YO8 RU https://pubmed.ncbi.nlm.nih.gov/12537309 DMLJHM2 DI DMLJHM2 DMLJHM2 DN PD-L1 t-haNK DMLJHM2 MI TT8ZLTI DMLJHM2 MN Programmed cell death 1 ligand 1 (PD-L1) DMLJHM2 MT DTT DMLJHM2 RN ClinicalTrials.gov (NCT04050709) QUILT 3.064: PD-L1 t-haNK In Subjects With Locally Advanced Or Metastatic Solid Cancers. U.S. National Institutes of Health. DMLJHM2 RU https://clinicaltrials.gov/ct2/show/NCT04050709 DM4CY2G DI DM4CY2G DM4CY2G DN PEDF gene therapy DM4CY2G MI TTR59S1 DM4CY2G MN Pigment epithelium-derived factor (SERPINF1) DM4CY2G MT DTT DM4CY2G MA Inhibitor DM4CY2G RN Adenovector pigment epithelium-derived factor (AdPEDF) delivery for wet age-related macular degeneration. Retina. 2005 Dec;25(8 Suppl):S48-S49. DM4CY2G RU https://pubmed.ncbi.nlm.nih.gov/16374334 DMB5JWX DI DMB5JWX DMB5JWX DN Pegadricase DMB5JWX MI TTZ1SWF DMB5JWX MN Uric acid (URA) DMB5JWX MT DTT DMB5JWX MA Modulator DMB5JWX RN Uricase formulated with polyethylene glycol (uricase-PEG 20): biochemical rationale and preclinical studies. J Rheumatol. 2002 Sep;29(9):1942-9. DMB5JWX RU https://pubmed.ncbi.nlm.nih.gov/12233890 DMW7VGZ DI DMW7VGZ DMW7VGZ DN PegCNTF DMW7VGZ MI TTT2F9E DMW7VGZ MN Ciliary neurotrophic factor receptor alpha (CNTFR) DMW7VGZ MT DTT DMW7VGZ MA Agonist DMW7VGZ RN Emerging drugs for obesity: linking novel biological mechanisms to pharmaceutical pipelines. Expert Opin Emerg Drugs. 2005 Aug;10(3):643-60. DMW7VGZ RU https://pubmed.ncbi.nlm.nih.gov/16083333 DMW7VGZ DI DMW7VGZ DMW7VGZ DN PegCNTF DMW7VGZ MI TTQL5VC DMW7VGZ MN Platelet-activating factor receptor (PTAFR) DMW7VGZ MT DTT DMW7VGZ MA Modulator DMW7VGZ RN Sch 37370: a new drug combining antagonism of platelet-activating factor (PAF) with antagonism of histamine. Agents Actions Suppl. 1991;34:313-21. DMW7VGZ RU https://pubmed.ncbi.nlm.nih.gov/1793070 DM0E37K DI DM0E37K DM0E37K DN Pegdinetanib DM0E37K MI TTUTJGQ DM0E37K MN Vascular endothelial growth factor receptor 2 (KDR) DM0E37K MT DTT DM0E37K MA Modulator DM0E37K RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1813). DM0E37K RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1813 DMQ4Z1P DI DMQ4Z1P DMQ4Z1P DN Peginterferon beta DMQ4Z1P MI TTRMX3V DMQ4Z1P MN Janus kinase 2 (JAK-2) DMQ4Z1P MT DTT DMQ4Z1P MA Inhibitor DMQ4Z1P RN Comparison of mutated ABL1 and JAK2 as oncogenes and drug targets in myeloproliferative disorders. Leukemia. 2008 Jul;22(7):1320-34. DMQ4Z1P RU https://pubmed.ncbi.nlm.nih.gov/18528425 DMMEPKR DI DMMEPKR DMMEPKR DN PEG-Interferon lambda (IL-29) DMMEPKR MI TTM624L DMMEPKR MN Interleukin-29 (IL29) DMMEPKR MT DTT DMMEPKR MA Agonist DMMEPKR RN Preclinical and clinical development of pegylated interferon-lambda 1 in chronic hepatitis C. J Interferon Cytokine Res. 2010 Aug;30(8):591-5. DMMEPKR RU https://pubmed.ncbi.nlm.nih.gov/20645873 DMHV58T DI DMHV58T DMHV58T DN Peldesine DMHV58T MI TTMCF1Y DMHV58T MN Purine nucleoside phosphorylase (PNP) DMHV58T MT DTT DMHV58T MA Inhibitor DMHV58T RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMHV58T RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMTEG6B DI DMTEG6B DMTEG6B DN PENCLOMEDINE DMTEG6B MI TTUTN1I DMTEG6B MN Human Deoxyribonucleic acid (hDNA) DMTEG6B MT DTT DMTEG6B MA Modulator DMTEG6B RN The alkylating agent penclomedine induces degeneration of purkinje cells in the rat cerebellum. Invest New Drugs. 2003 Aug;21(3):269-79. DMTEG6B RU https://www.ncbi.nlm.nih.gov/pubmed/14578677 DM0BNLC DI DM0BNLC DM0BNLC DN PENNVAX-6 DM0BNLC MI TTEC2T3 DM0BNLC MN Human immunodeficiency virus Envelope glycoprotein gp160 (HIV env) DM0BNLC MT DTT DM0BNLC MA Modulator DM0BNLC RN Company report (Inovio) DM0BNLC RU http://www.inovio.com/products/infectious-disease-vaccines/hiv/pennvax-g/ DMUTISK DI DMUTISK DMUTISK DN Pennvax-B DMUTISK MI TTUTN1I DMUTISK MN Human Deoxyribonucleic acid (hDNA) DMUTISK MT DTT DMUTISK RN Synthetic consensus HIV-1 DNA induces potent cellular immune responses and synthesis of granzyme B, perforin in HIV infected individuals. Mol Ther. 2015 Mar;23(3):591-601. DMUTISK RU https://pubmed.ncbi.nlm.nih.gov/25531694 DM7YX8G DI DM7YX8G DM7YX8G DN Pennvax-G DM7YX8G MI TTUTN1I DM7YX8G MN Human Deoxyribonucleic acid (hDNA) DM7YX8G MT DTT DM7YX8G RN Synthetic consensus HIV-1 DNA induces potent cellular immune responses and synthesis of granzyme B, perforin in HIV infected individuals. Mol Ther. 2015 Mar;23(3):591-601. DM7YX8G RU https://pubmed.ncbi.nlm.nih.gov/25531694 DMVYRH2 DI DMVYRH2 DMVYRH2 DN Perifosine DMVYRH2 MI TTHBTOP DMVYRH2 MN PI3-kinase gamma (PIK3CG) DMVYRH2 MT DTT DMVYRH2 MA Modulator DMVYRH2 RN Company report (Aezsinc) DMVYRH2 RU http://www.aezsinc.com/en/page.php?p=60&q=504 DM5PUO0 DI DM5PUO0 DM5PUO0 DN PF-00337210 DM5PUO0 MI TTUTJGQ DM5PUO0 MN Vascular endothelial growth factor receptor 2 (KDR) DM5PUO0 MT DTT DM5PUO0 MA Modulator DM5PUO0 RN Inhibition of VEGFR-2 Reverses Type 1 Diabetes in NOD Mice by Abrogating Insulitis and Restoring Islet Function. Diabetes. 2013 August; 62(8): 2870-2878. DM5PUO0 RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3717875/ DM93LMS DI DM93LMS DM93LMS DN PF-01247324 DM93LMS MI TT90XZ8 DM93LMS MN Voltage-gated sodium channel alpha Nav1.8 (SCN10A) DM93LMS MT DTT DM93LMS MA Blocker DM93LMS RN Oral Administration of PF-01247324, a Subtype-Selective Nav1.8 Blocker, Reverses Cerebellar Deficits in a Mouse Model of Multiple Sclerosis. PLoS One. 2015; 10(3): e0119067. DM93LMS RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4352054/ DMLGD0V DI DMLGD0V DMLGD0V DN PF-04776548 DMLGD0V MI TT5FNQT DMLGD0V MN Human immunodeficiency virus Protease (HIV PR) DMLGD0V MT DTT DMLGD0V MA Modulator DMLGD0V RN ClinicalTrials.gov (NCT01045317) A Study To Investigate The Clearance Of PF-04776548 From The Body Following A Very Low (Micro) Dose Of The Compound Using A Low Level Of Radiotracer To Help Quantify Expected Low Concentrations Of PF-04776548 In The Body. U.S. National Institutes of Health. DMLGD0V RU https://clinicaltrials.gov/ct2/show/NCT01045317 DMDSCQG DI DMDSCQG DMDSCQG DN PF-04840082 DMDSCQG MI TTE3RAC DMDSCQG MN Dickkopf-related protein 1 (DKK1) DMDSCQG MT DTT DMDSCQG MA Modulator DMDSCQG RN The application of target information and preclinical pharmacokinetic/pharmacodynamic modeling in predicting clinical doses of a Dickkopf-1 antibody for osteoporosis. J Pharmacol Exp Ther. 2010 Apr;333(1):2-13. DMDSCQG RU https://pubmed.ncbi.nlm.nih.gov/20089807 DMZ8QRI DI DMZ8QRI DMZ8QRI DN PF-04995274 DMZ8QRI MI TT07C3Y DMZ8QRI MN 5-HT 4 receptor (HTR4) DMZ8QRI MT DTT DMZ8QRI MA Agonist DMZ8QRI RN Pharmacokinetics, safety and tolerability of PF04995274: A 5HT4 partial agonist being developed for the treatment of Alzheimer's disease. Alzheimer's and Dementia. DMZ8QRI RU http://www.alzheimersanddementia.com/article/S1552-5260(11)02414-9/abstract DMAEK3L DI DMAEK3L DMAEK3L DN PF-05082566 DMAEK3L MI TTPW9LJ DMAEK3L MN Co-stimulatory molecule 4-1BB (CD137) DMAEK3L MT DTT DMAEK3L MA Modulator DMAEK3L RN Targeting of 4-1BB by monoclonal antibody PF-05082566 enhances T-cell function and promotes anti-tumor activity. Cancer Immunol Immunother. 2012 Oct;61(10):1721-33. DMAEK3L RU https://pubmed.ncbi.nlm.nih.gov/22406983 DM4QPT0 DI DM4QPT0 DM4QPT0 DN PF-05105679 DM4QPT0 MI TTXDKTO DM4QPT0 MN Long transient receptor potential channel 8 (TRPM8) DM4QPT0 MT DTT DM4QPT0 MA Modulator DM4QPT0 RN Inhibition of TRPM8 channels reduces pain in the cold pressor test in humans. J Pharmacol Exp Ther. 2014 Nov;351(2):259-69. DM4QPT0 RU https://pubmed.ncbi.nlm.nih.gov/25125580 DMUF6W9 DI DMUF6W9 DMUF6W9 DN PF-05186462 DMUF6W9 MI TT4G2JS DMUF6W9 MN Voltage-gated sodium channel alpha Nav1.7 (SCN9A) DMUF6W9 MT DTT DMUF6W9 MA Inhibitor DMUF6W9 RN Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800026875) DMUF6W9 RU http://adisinsight.springer.com/drugs/800026875 DM7B2JC DI DM7B2JC DM7B2JC DN PF-05190457 DM7B2JC MI TTWDC17 DM7B2JC MN Growth hormone secretagogue receptor 1 (GHSR) DM7B2JC MT DTT DM7B2JC MA Modulator DM7B2JC RN A gift for research. SciBX 7(6); doi:10.1038/scibx.2014.160. Feb. 13 2014 DM7B2JC RU http://www.nature.com/scibx/journal/v7/n6/full/scibx.2014.160.html DM7OC9K DI DM7OC9K DM7OC9K DN PF-05230905 DM7OC9K MI TTF8CQI DM7OC9K MN Tumor necrosis factor (TNF) DM7OC9K MT DTT DM7OC9K MA Inhibitor DM7OC9K RN Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800033173) DM7OC9K RU http://adisinsight.springer.com/drugs/800033173 DM7GSZL DI DM7GSZL DM7GSZL DN PF-05230907 DM7GSZL MI TTGKNB4 DM7GSZL MN Epidermal growth factor receptor (EGFR) DM7GSZL MT DTT DM7GSZL MA Inhibitor DM7GSZL RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DM7GSZL RU http://phrma-docs.phrma.org/sites/default/files/pdf/medicines-in-development-drug-list-rare-diseases.pdf DMQYBSH DI DMQYBSH DMQYBSH DN PF-05231023 DMQYBSH MI TTQ916P DMQYBSH MN Fibroblast growth factor-21 (FGF21) DMQYBSH MT DTT DMQYBSH RN Mechanistic investigation of the preclinical pharmacokinetics and interspecies scaling of PF-05231023, a fibroblast growth factor 21-antibody protein conjugate. Drug Metab Dispos. 2015 Jun;43(6):803-11. DMQYBSH RU https://pubmed.ncbi.nlm.nih.gov/25805881 DM2NTBL DI DM2NTBL DM2NTBL DN PF-05241328 DM2NTBL MI TT4G2JS DM2NTBL MN Voltage-gated sodium channel alpha Nav1.7 (SCN9A) DM2NTBL MT DTT DM2NTBL MA Inhibitor DM2NTBL RN Recent progress in sodium channel modulators for pain. Bioorg Med Chem Lett. 2014 Aug 15;24(16):3690-9. DM2NTBL RU https://pubmed.ncbi.nlm.nih.gov/25060923 DM5KBDY DI DM5KBDY DM5KBDY DN PF-06263507 DM5KBDY MI TT70MLA DM5KBDY MN Oncotrophoblast glycoprotein 5T4 (TPBG) DM5KBDY MT DTT DM5KBDY RN National Cancer Institute Drug Dictionary (drug id 751006). DM5KBDY RU http://www.cancer.gov/publications/dictionaries/cancer-drug?cdrid=751006 DMASKX9 DI DMASKX9 DMASKX9 DN PF-06342674 DMASKX9 MI TTAWI51 DMASKX9 MN Interleukin 7 receptor alpha (IL7R) DMASKX9 MT DTT DMASKX9 MA Antagonist DMASKX9 RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMASKX9 RU http://phrma-docs.phrma.org/files/dmfile/medicines-in-development-drug-list-autoimmune-diseases.pdf DMGB32Z DI DMGB32Z DMGB32Z DN PF-06427878 DMGB32Z MI TTRHEQ4 DMGB32Z MN Diacylglycerol O-acyltransferase 2 (DGAT2) DMGB32Z MT DTT DMGB32Z MA Inhibitor DMGB32Z RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMGB32Z RU http://phrma-docs.phrma.org/files/dmfile/2018_Heart-Disease-and-Stroke_MID-Drug-List.pdf DM9UZTO DI DM9UZTO DM9UZTO DN PF-06444752 DM9UZTO MI TTYJQTF DM9UZTO MN Immunoglobulin E (IgE) DM9UZTO MT DTT DM9UZTO MA Modulator DM9UZTO RN ClinicalTrials.gov (NCT01723254) A Study To Assess The Safety And Tolerability Of Different Doses Of PF-06444753 And PF-06444752 In Subjects With Allergic Rhinitis. U.S. National Institutes of Health. DM9UZTO RU https://clinicaltrials.gov/ct2/show/NCT01723254 DMNLK5Y DI DMNLK5Y DMNLK5Y DN PF-06647020 DMNLK5Y MI TTXH2ZN DMNLK5Y MN Inactive tyrosine-protein kinase 7 (PTK7) DMNLK5Y MT DTT DMNLK5Y MA Inhibitor DMNLK5Y RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMNLK5Y RU http://phrma-docs.phrma.org/files/dmfile/MID_Immuno-Oncology-2017_Drug-List1.pdf DMGUKRN DI DMGUKRN DMGUKRN DN PF-06648671 DMGUKRN MI TT9W8GU DMGUKRN MN Gamma-secretase (GS) DMGUKRN MT DTT DMGUKRN MA Modulator DMGUKRN RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMGUKRN RU http://phrma-docs.phrma.org/files/dmfile/MID-Update_Alzheimers-Disease_2017-Drug-List.pdf DM056JD DI DM056JD DM056JD DN PF-06648671 DM056JD MI TT9W8GU DM056JD MN Gamma-secretase (GS) DM056JD MT DTT DM056JD MA Modulator DM056JD RN Pharmacokinetic and Pharmacodynamic Effects of a -Secretase Modulator, PF-06648671, on CSF Amyloid- Peptides in Randomized Phase I Studies. Clin Pharmacol Ther. 2020 Jan;107(1):211-220. DM056JD RU https://pubmed.ncbi.nlm.nih.gov/31314925 DMK19V6 DI DMK19V6 DMK19V6 DN PF-06671008 DMK19V6 MI TTARMD9 DMK19V6 MN Placental cadherin (CDH3) DMK19V6 MT DTT DMK19V6 MA Immunomodulator DMK19V6 RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMK19V6 RU http://phrma-docs.phrma.org/files/dmfile/MID_Immuno-Oncology-2017_Drug-List1.pdf DM2ZJ1C DI DM2ZJ1C DM2ZJ1C DN PF-06747143 DM2ZJ1C MI TTBID49 DM2ZJ1C MN C-X-C chemokine receptor type 4 (CXCR4) DM2ZJ1C MT DTT DM2ZJ1C MA Antagonist DM2ZJ1C RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DM2ZJ1C RU http://phrma-docs.phrma.org/files/dmfile/MID_Immuno-Oncology-2017_Drug-List1.pdf DMQUNRW DI DMQUNRW DMQUNRW DN PF-06763809 DMQUNRW MI TTRX125 DMQUNRW MN Transcription factor unspecific (TF) DMQUNRW MT DTT DMQUNRW MA Inhibitor DMQUNRW RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMQUNRW RU http://phrma-docs.phrma.org/files/dmfile/MID_Skin_Diseases_2018_9_FINAL.pdf DMDE9I6 DI DMDE9I6 DMDE9I6 DN PF-06801591 DMDE9I6 MI TTNBFWK DMDE9I6 MN Programmed cell death protein 1 (PD-1) DMDE9I6 MT DTT DMDE9I6 RN Development of Inhibitors of the Programmed Cell Death-1/Programmed Cell Death-Ligand 1 Signaling Pathway.J Med Chem. 2019 Feb 28;62(4):1715-1730. DMDE9I6 RU https://pubmed.ncbi.nlm.nih.gov/30247903 DMSJOTL DI DMSJOTL DMSJOTL DN PF-06817024 DMSJOTL MI TTFTSHD DMSJOTL MN Cytokine unspecific (CYK) DMSJOTL MT DTT DMSJOTL MA Modulator DMSJOTL RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMSJOTL RU http://phrma-docs.phrma.org/files/dmfile/MID_Skin_Diseases_2018_9_FINAL.pdf DML3WT6 DI DML3WT6 DML3WT6 DN PF-06821497 DML3WT6 MI TT9MZCQ DML3WT6 MN Enhancer of zeste homolog 2 (EZH2) DML3WT6 MT DTT DML3WT6 MA Inhibitor DML3WT6 RN Optimization of Orally Bioavailable Enhancer of Zeste Homolog 2 (EZH2) Inhibitors Using Ligand and Property-Based Design Strategies: Identification of Development Candidate (R)-5,8-Dichloro-7-(methoxy(oxetan-3-yl)methyl)-2-((4-methoxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-3,4-dihydroisoquinolin-1(2H)-one (PF-06821497). J Med Chem. 2018 Feb 8;61(3):650-665. DML3WT6 RU https://pubmed.ncbi.nlm.nih.gov/29211475 DMRGVT9 DI DMRGVT9 DMRGVT9 DN PF-06826647 DMRGVT9 MI TTBYWP2 DMRGVT9 MN TYK2 tyrosine kinase (TYK2) DMRGVT9 MT DTT DMRGVT9 MA Inhibitor DMRGVT9 RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMRGVT9 RU http://phrma-docs.phrma.org/files/dmfile/MID_Skin_Diseases_2018_9_FINAL.pdf DMOX6EJ DI DMOX6EJ DMOX6EJ DN PF-06840003 DMOX6EJ MI TTZJYKH DMOX6EJ MN Indoleamine 2,3-dioxygenase 1 (IDO1) DMOX6EJ MT DTT DMOX6EJ MA Inhibitor DMOX6EJ RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMOX6EJ RU http://phrma-docs.phrma.org/files/dmfile/MID_Neurological-Disorders-Drug-List_2018.pdf DMRZHV6 DI DMRZHV6 DMRZHV6 DN PF-06873600 DMRZHV6 MI TTMBO1Z DMRZHV6 MN Cyclin-dependent kinase (CDK) DMRZHV6 MT DTT DMRZHV6 MA Inhibitor DMRZHV6 RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMRZHV6 RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DM7BOFR DI DM7BOFR DM7BOFR DN PF-06939999 DM7BOFR MI TTR1D7X DM7BOFR MN Protein arginine methyltransferase 5 (PRMT5) DM7BOFR MT DTT DM7BOFR MA Inhibitor DM7BOFR RN National Cancer Institute Drug Dictionary (drug name PF-06939999). DM7BOFR RU https://www.cancer.gov/publications/dictionaries/cancer-drug/def/protein-arginine-methyltransferase-5-inhibitor-pf-06939999 DMYP9WR DI DMYP9WR DMYP9WR DN PF-06940434 DMYP9WR MI TT7B3HE DMYP9WR MN Integrin alpha-V/beta-8 (ITGAV/B8) DMYP9WR MT DTT DMYP9WR MA Antagonist DMYP9WR RN ClinicalTrials.gov (NCT04152018) Study of PF-06940434 in Patients With Advanced or Metastatic Solid Tumors.. U.S. National Institutes of Health. DMYP9WR RU https://clinicaltrials.gov/ct2/show/NCT04152018 DMDQJEZ DI DMDQJEZ DMDQJEZ DN PF-06952229 DMDQJEZ MI TTP4520 DMDQJEZ MN TGF-beta receptor type I (TGFBR1) DMDQJEZ MT DTT DMDQJEZ MA Inhibitor DMDQJEZ RN Targeting the TGF pathway for cancer therapy. Pharmacol Ther. 2015 Mar;147:22-31. DMDQJEZ RU https://pubmed.ncbi.nlm.nih.gov/25444759 DME3BJL DI DME3BJL DME3BJL DN PF-07062119 DME3BJL MI TTLDPRG DME3BJL MN Guanylyl cyclase C (GUCY2C) DME3BJL MT DTT DME3BJL MA Inhibitor DME3BJL RN Discovery and optimization of a novel anti-GUCY2c x CD3 bispecific antibody for the treatment of solid tumors. MAbs. Jan-Dec 2021;13(1):1850395. DME3BJL RU https://pubmed.ncbi.nlm.nih.gov/33459147 DME3BJL DI DME3BJL DME3BJL DN PF-07062119 DME3BJL MI TTUN7MC DME3BJL MN T-cell surface glycoprotein CD3 (CD3) DME3BJL MT DTT DME3BJL MA Inhibitor DME3BJL RN Discovery and optimization of a novel anti-GUCY2c x CD3 bispecific antibody for the treatment of solid tumors. MAbs. Jan-Dec 2021;13(1):1850395. DME3BJL RU https://pubmed.ncbi.nlm.nih.gov/33459147 DMMJZ2E DI DMMJZ2E DMMJZ2E DN PF-07104091 DMMJZ2E MI TT7HF4W DMMJZ2E MN Cyclin-dependent kinase 2 (CDK2) DMMJZ2E MT DTT DMMJZ2E MA Inhibitor DMMJZ2E RN ClinicalTrials.gov (NCT04553133) PF-07104091 as a Single Agent and in Combination Therapy. U.S. National Institutes of Health. DMMJZ2E RU https://clinicaltrials.gov/ct2/show/NCT04553133 DMPKO84 DI DMPKO84 DMPKO84 DN PF-07220060 DMPKO84 MI TT0PG8F DMPKO84 MN Cyclin-dependent kinase 4 (CDK4) DMPKO84 MT DTT DMPKO84 MA Inhibitor DMPKO84 RN ClinicalTrials.gov (NCT04557449) Study to Test the Safety and Tolerability of PF-07220060 in Participants With Advance Solid Tumors (CDK4). U.S. National Institutes of Health. DMPKO84 RU https://clinicaltrials.gov/ct2/show/NCT04557449 DMSMNRQ DI DMSMNRQ DMSMNRQ DN PF-07265807 DMSMNRQ MI TTO7LKR DMSMNRQ MN Tyrosine-protein kinase Mer (MERTK) DMSMNRQ MT DTT DMSMNRQ MA Inhibitor DMSMNRQ RN National Cancer Institute Drug Dictionary (drug name PF-07265807). DMSMNRQ RU https://www.cancer.gov/publications/dictionaries/cancer-drug/def/axl-mer-inhibitor-pf-07265807 DMSMNRQ DI DMSMNRQ DMSMNRQ DN PF-07265807 DMSMNRQ MI TTZPY6J DMSMNRQ MN Tyrosine-protein kinase UFO (AXL) DMSMNRQ MT DTT DMSMNRQ MA Inhibitor DMSMNRQ RN National Cancer Institute Drug Dictionary (drug name PF-07265807). DMSMNRQ RU https://www.cancer.gov/publications/dictionaries/cancer-drug/def/axl-mer-inhibitor-pf-07265807 DMCOUHT DI DMCOUHT DMCOUHT DN PF-2413873 DMCOUHT MI TTUV8G9 DMCOUHT MN Progesterone receptor (PGR) DMCOUHT MT DTT DMCOUHT MA Antagonist DMCOUHT RN Unusual base-catalyzed exchange in the synthesis of deuterated PF-2413873. Journal of Labelled Compounds. 08/2009; 52(10):435 - 442. DMCOUHT RU http://onlinelibrary.wiley.com/doi/10.1002/jlcr.1657/abstract DMG2IE5 DI DMG2IE5 DMG2IE5 DN PF-3732010 DMG2IE5 MI TTARMD9 DMG2IE5 MN Placental cadherin (CDH3) DMG2IE5 MT DTT DMG2IE5 RN National Cancer Institute Drug Dictionary (drug id 580366). DMG2IE5 RU http://www.cancer.gov/publications/dictionaries/cancer-drug?cdrid=580366 DM36PKZ DI DM36PKZ DM36PKZ DN PF-3758309 DM36PKZ MI TT7Y3BZ DM36PKZ MN PAK-4 protein kinase (PAK4) DM36PKZ MT DTT DM36PKZ MA Inhibitor DM36PKZ RN Small-molecule p21-activated kinase inhibitor PF-3758309 is a potent inhibitor of oncogenic signaling and tumor growth. Proc Natl Acad Sci U S A. 2010 May 18;107(20):9446-51. DM36PKZ RU https://pubmed.ncbi.nlm.nih.gov/20439741 DML0OCD DI DML0OCD DML0OCD DN PF-3864086 DML0OCD MI TTMI6F5 DML0OCD MN Transient receptor potential cation channel V1 (TRPV1) DML0OCD MT DTT DML0OCD MA Antagonist DML0OCD RN Clinical pipeline report, company report or official report of pfizer. DML0OCD RU https://www.pfizer.com/files/investors/presentations/acr_102808_v2.pdf DMU2A6D DI DMU2A6D DMU2A6D DN PF-4217903 DMU2A6D MI TTNDSF4 DMU2A6D MN Proto-oncogene c-Met (MET) DMU2A6D MT DTT DMU2A6D MA Inhibitor DMU2A6D RN Sensitivity of selected human tumor models to PF-04217903, a novel selective c-Met kinase inhibitor. Mol Cancer Ther. 2012 Apr;11(4):1036-47. DMU2A6D RU https://pubmed.ncbi.nlm.nih.gov/22389468 DMMETU8 DI DMMETU8 DMMETU8 DN PF-4418948 DMMETU8 MI TT1ZAVI DMMETU8 MN Prostaglandin E2 receptor EP2 (PTGER2) DMMETU8 MT DTT DMMETU8 MA Antagonist DMMETU8 RN Evaluation of WO 2012/177618 A1 and US-2014/0179750 A1: novel small molecule antagonists of prostaglandin-E2 receptor EP2.Expert Opin Ther Pat. 2015 Jul;25(7):837-44. DMMETU8 RU https://www.ncbi.nlm.nih.gov/pubmed/25772215 DM3427C DI DM3427C DM3427C DN PF-4427429 DM3427C MI TTAFORY DM3427C MN Calcitonin gene-related peptide (CALC) DM3427C MT DTT DM3427C MA Modulator DM3427C RN Teva Announces Positive Results for TEV-48125 in Phase IIb Chronic Migraine Study Meeting Primary and Secondary Endpoints DM3427C RU http://www.tevapharm.com/news/teva_announces_positive_results_for_tev_48125_in_phase_iib_chronic_migraine_study_meeting_primary_and_secondary_endpoints_02_15.aspx DMYR7XP DI DMYR7XP DMYR7XP DN PF-4455242 DMYR7XP MI TTQW87Y DMYR7XP MN Opioid receptor kappa (OPRK1) DMYR7XP MT DTT DMYR7XP MA Modulator DMYR7XP RN Design and discovery of a selective small molecule opioid antagonist (2-methyl-N-((2'-(pyrrolidin-1-ylsulfonyl)biphenyl-4-yl)methyl)propan-1-amine, PF-4455242). J Med Chem. 2011 Aug 25;54(16):5868-77. DMYR7XP RU https://pubmed.ncbi.nlm.nih.gov/21744827 DMKOE84 DI DMKOE84 DMKOE84 DN PF-4603629 DMKOE84 MI TTVIMDE DMKOE84 MN Glucagon-like peptide 1 receptor (GLP1R) DMKOE84 MT DTT DMKOE84 MA Modulator DMKOE84 RN Exenatide and liraglutide: different approaches to develop GLP-1 receptor agonists (incretin mimetics)--preclinical and clinical results. Best Pract Res Clin Endocrinol Metab. 2009 Aug;23(4):463-77. DMKOE84 RU https://pubmed.ncbi.nlm.nih.gov/19748064 DMSLE03 DI DMSLE03 DMSLE03 DN PF-562271 DMSLE03 MI TTON5IT DMSLE03 MN Focal adhesion kinase 1 (FAK) DMSLE03 MT DTT DMSLE03 MA Inhibitor DMSLE03 RN Inhibition of focal adhesion kinase by PF-562,271 inhibits the growth and metastasis of pancreatic cancer concomitant with altering the tumor microenvironment. Mol Cancer Ther. 2011 Nov;10(11):2135-45. DMSLE03 RU https://pubmed.ncbi.nlm.nih.gov/21903606 DMGLEM1 DI DMGLEM1 DMGLEM1 DN PF9601N DMGLEM1 MI TTGP7BY DMGLEM1 MN Monoamine oxidase type B (MAO-B) DMGLEM1 MT DTT DMGLEM1 MA Inhibitor DMGLEM1 RN Drugs used to treat Parkinson's disease, present status and future directions. CNS Neurol Disord Drug Targets. 2008 Oct;7(4):321-42. DMGLEM1 RU https://pubmed.ncbi.nlm.nih.gov/18991661 DMLDZX1 DI DMLDZX1 DMLDZX1 DN PfAMA-1 DMLDZX1 MI TTQZW34 DMLDZX1 MN Plasmodium Apical membrane protein (Malaria AMA-1) DMLDZX1 MT DTT DMLDZX1 RN Plasmodium falciparum apical membrane antigen 1 (PfAMA-1) is translocated within micronemes along subpellicular microtubules during merozoite devel... J Cell Sci. 2003 Sep 15;116(Pt 18):3825-34. DMLDZX1 RU https://pubmed.ncbi.nlm.nih.gov/12902400 DM6ER9L DI DM6ER9L DM6ER9L DN Pfizer 10 DM6ER9L MI TT4C8EA DM6ER9L MN Dopamine D3 receptor (D3R) DM6ER9L MT DTT DM6ER9L MA Agonist DM6ER9L RN Designing drugs for the treatment of female sexual dysfunction. Drug Discov Today. 2007 Sep;12(17-18):757-66. DM6ER9L RU https://pubmed.ncbi.nlm.nih.gov/17826689 DMME5P8 DI DMME5P8 DMME5P8 DN Pfizer 4 DMME5P8 MI TT5TKPM DMME5P8 MN Neutral endopeptidase (MME) DMME5P8 MT DTT DMME5P8 MA Inhibitor DMME5P8 RN Designing drugs for the treatment of female sexual dysfunction. Drug Discov Today. 2007 Sep;12(17-18):757-66. DMME5P8 RU https://pubmed.ncbi.nlm.nih.gov/17826689 DMIR21F DI DMIR21F DMIR21F DN PFK-158 DMIR21F MI TTTHMQJ DMIR21F MN Renal carcinoma antigen NY-REN-56 (PFKFB3) DMIR21F MT DTT DMIR21F MA Inhibitor DMIR21F RN Discovery of a PFKFB3 inhibitor for phase I trial testing that synergizes with the B-Raf inhibitor vemurafenib. Cancer Metab. 2014; 2(Suppl 1): P14. DMIR21F RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4072985/ DM68D3O DI DM68D3O DM68D3O DN PG-545 DM68D3O MI TTR7GJO DM68D3O MN Heparanase (HPSE) DM68D3O MT DTT DM68D3O MA Modulator DM68D3O RN PG545, a dual heparanase and angiogenesis inhibitor, induces potent anti-tumour and anti-metastatic efficacy in preclinical models. Br J Cancer. 2011 Feb 15;104(4):635-42. DM68D3O RU https://pubmed.ncbi.nlm.nih.gov/21285983 DM2Y4FG DI DM2Y4FG DM2Y4FG DN PHA-793887 DM2Y4FG MI TTH6V3D DM2Y4FG MN Cyclin-dependent kinase 1 (CDK1) DM2Y4FG MT DTT DM2Y4FG MA Inhibitor DM2Y4FG RN A first in man, phase I dose-escalation study of PHA-793887, an inhibitor of multiple cyclin-dependent kinases (CDK2, 1 and 4) reveals unexpected h... Cell Cycle. 2011 Mar 15;10(6):963-70. DM2Y4FG RU https://pubmed.ncbi.nlm.nih.gov/21368575 DM2Y4FG DI DM2Y4FG DM2Y4FG DN PHA-793887 DM2Y4FG MI TT7HF4W DM2Y4FG MN Cyclin-dependent kinase 2 (CDK2) DM2Y4FG MT DTT DM2Y4FG MA Inhibitor DM2Y4FG RN A first in man, phase I dose-escalation study of PHA-793887, an inhibitor of multiple cyclin-dependent kinases (CDK2, 1 and 4) reveals unexpected h... Cell Cycle. 2011 Mar 15;10(6):963-70. DM2Y4FG RU https://pubmed.ncbi.nlm.nih.gov/21368575 DM2Y4FG DI DM2Y4FG DM2Y4FG DN PHA-793887 DM2Y4FG MI TT0PG8F DM2Y4FG MN Cyclin-dependent kinase 4 (CDK4) DM2Y4FG MT DTT DM2Y4FG MA Inhibitor DM2Y4FG RN Liposarcoma: molecular genetics and therapeutics. Sarcoma. 2011;2011:483154. DM2Y4FG RU https://pubmed.ncbi.nlm.nih.gov/21253554 DMUANF9 DI DMUANF9 DMUANF9 DN PHE-377 DMUANF9 MI TTMI6F5 DMUANF9 MN Transient receptor potential cation channel V1 (TRPV1) DMUANF9 MT DTT DMUANF9 MA Antagonist DMUANF9 RN Clinical pipeline report, company report or official report of Pharmeste. DMUANF9 RU http://www.pharmeste.com/home.asp?op=interna&id=1 DMBZ2QT DI DMBZ2QT DMBZ2QT DN PHE885 DMBZ2QT MI TTZ3P4W DMBZ2QT MN B-cell maturation protein (TNFRSF17) DMBZ2QT MT DTT DMBZ2QT RN ClinicalTrials.gov (NCT04318327) BCMA-directed CAR-T Cell Therapy in Adult Patients With Relapsed and/or Refractory Multiple Myeloma. U.S. National Institutes of Health. DMBZ2QT RU https://clinicaltrials.gov/ct2/show/NCT04318327 DMERJ6V DI DMERJ6V DMERJ6V DN PHX-1766 DMERJ6V MI TTRHUKY DMERJ6V MN Hepatitis C virus Serine protease NS4A (HCV NS4A) DMERJ6V MT DTT DMERJ6V MA Modulator DMERJ6V RN Pharmacokinetics and antiviral activity of PHX1766, a novel HCV protease inhibitor, using an accelerated Phase I study design. Antivir Ther. 2012;17(2):365-75. DMERJ6V RU https://pubmed.ncbi.nlm.nih.gov/22293533 DMU26OE DI DMU26OE DMU26OE DN PIM447 DMU26OE MI TTA7WGU DMU26OE MN Serine/threonine-protein kinase pim (PIM) DMU26OE MT DTT DMU26OE MA Inhibitor DMU26OE RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMU26OE RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DMF3IBC DI DMF3IBC DMF3IBC DN Plasma derived human butyrylcholinesterase DMF3IBC MI TTEB0GD DMF3IBC MN Cholinesterase (BCHE) DMF3IBC MT DTT DMF3IBC MA Modulator DMF3IBC RN Acetylcholinesterase-Fc Fusion Protein (AChE-Fc): A Novel Potential Organophosphate Bioscavenger with Extended Plasma Half-Life. Bioconjug Chem. 2015 Aug 19;26(8):1753-8. DMF3IBC RU https://pubmed.ncbi.nlm.nih.gov/26121420 DMBK9AM DI DMBK9AM DMBK9AM DN PLX-4720 DMBK9AM MI TT0EOB8 DMBK9AM MN B-Raf messenger RNA (BRAF mRNA) DMBK9AM MT DTT DMBK9AM MA Inhibitor DMBK9AM RN Comprehensive analysis of kinase inhibitor selectivity. Nat Biotechnol. 2011 Oct 30;29(11):1046-51. DMBK9AM RU https://pubmed.ncbi.nlm.nih.gov/22037378 DMBK9AM DI DMBK9AM DMBK9AM DN PLX-4720 DMBK9AM MI TTUTJGQ DMBK9AM MN Vascular endothelial growth factor receptor 2 (KDR) DMBK9AM MT DTT DMBK9AM MA Inhibitor DMBK9AM RN In vivo antitumor activity of SU11248, a novel tyrosine kinase inhibitor targeting vascular endothelial growth factor and platelet-derived growth factor receptors: determination of a pharmacokinetic/pharmacodynamic relationship. Clin Cancer Res. 2003 Jan;9(1):327-37. DMBK9AM RU https://pubmed.ncbi.nlm.nih.gov/12538485 DMXLHVW DI DMXLHVW DMXLHVW DN PLX51107 DMXLHVW MI TTE4BSY DMXLHVW MN Bromodomain and extraterminal domain protein (BET) DMXLHVW MT DTT DMXLHVW MA Inhibitor DMXLHVW RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMXLHVW RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DMK4PWM DI DMK4PWM DMK4PWM DN PLX-5622 DMK4PWM MI TTC70AJ DMK4PWM MN Granulocyte colony-stimulating factor receptor (G-CSF-R) DMK4PWM MT DTT DMK4PWM MA Inhibitor DMK4PWM RN Microglial Stimulation of Glioblastoma Invasion Involves Epidermal Growth Factor Receptor (EGFR) and Colony Stimulating Factor 1 Receptor (CSF-1R) Signaling. Mol Med. 2012; 18(1): 519-527. DMK4PWM RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3356419/ DMED2WN DI DMED2WN DMED2WN DN PLX73086 DMED2WN MI TT0IQER DMED2WN MN Macrophage colony-stimulating factor 1 (CSF1) DMED2WN MT DTT DMED2WN MA Antagonist DMED2WN RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMED2WN RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DM0IVGU DI DM0IVGU DM0IVGU DN PLX7486 DM0IVGU MI TTC70AJ DM0IVGU MN Granulocyte colony-stimulating factor receptor (G-CSF-R) DM0IVGU MT DTT DM0IVGU MA Inhibitor DM0IVGU RN National Cancer Institute Drug Dictionary (drug id 747694). DM0IVGU RU http://www.cancer.gov/publications/dictionaries/cancer-drug?cdrid=747694 DM0IVGU DI DM0IVGU DM0IVGU DN PLX7486 DM0IVGU MI TT7MRDV DM0IVGU MN Macrophage colony-stimulating factor 1 receptor (CSF1R) DM0IVGU MT DTT DM0IVGU MA Inhibitor DM0IVGU RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DM0IVGU RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DM0IVGU DI DM0IVGU DM0IVGU DN PLX7486 DM0IVGU MI TTTDVOJ DM0IVGU MN Tropomyosin-related kinase A (TrkA) DM0IVGU MT DTT DM0IVGU MA Inhibitor DM0IVGU RN National Cancer Institute Drug Dictionary (drug id 747694). DM0IVGU RU http://www.cancer.gov/publications/dictionaries/cancer-drug?cdrid=747694 DMIS8BV DI DMIS8BV DMIS8BV DN PMD-026 DMIS8BV MI TTMVQXO DMIS8BV MN Ribosomal protein S6 kinase beta-2 (RPS6KB2) DMIS8BV MT DTT DMIS8BV MA Inhibitor DMIS8BV RN ClinicalTrials.gov (NCT04115306) Phase 1/1b Study of Oral PMD-026 in Patients With Metastatic Breast Cancer and Metastatic Triple Negative Breast Cancer. U.S. National Institutes of Health. DMIS8BV RU https://clinicaltrials.gov/ct2/show/NCT04115306 DMY9XWB DI DMY9XWB DMY9XWB DN PMI-005 DMY9XWB MI TTF8CQI DMY9XWB MN Tumor necrosis factor (TNF) DMY9XWB MT DTT DMY9XWB MA Inhibitor DMY9XWB RN US patent application no. 2008,0269,123, Methods for treating polycystic kidney disease (pkd) or other cyst forming diseases. DMY9XWB RU https://www.google.com.ar/patents/US20080269123 DMQ82SH DI DMQ82SH DMQ82SH DN PMZ-2123 DMQ82SH MI TTKRD0G DMQ82SH MN Endothelin A receptor (EDNRA) DMQ82SH MT DTT DMQ82SH MA Antagonist DMQ82SH RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMQ82SH RU http://phrma-docs.phrma.org/files/dmfile/mid-diabetes-drug-list.pdf DM9B68S DI DM9B68S DM9B68S DN POL-6014 DM9B68S MI TTPLTSQ DM9B68S MN Neutrophil elastase (NE) DM9B68S MT DTT DM9B68S MA Inhibitor DM9B68S RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2358). DM9B68S RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2358 DMTOLI5 DI DMTOLI5 DMTOLI5 DN Pomaglumetad DMTOLI5 MI TTXJ47W DMTOLI5 MN Metabotropic glutamate receptor 2 (mGluR2) DMTOLI5 MT DTT DMTOLI5 MA Modulator DMTOLI5 RN LY-2140023, a prodrug of the group II metabotropic glutamate receptor agonist LY-404039 for the potential treatment of schizophrenia. Curr Opin Investig Drugs. 2010 Jul;11(7):833-45. DMTOLI5 RU https://pubmed.ncbi.nlm.nih.gov/20571979 DMTOLI5 DI DMTOLI5 DMTOLI5 DN Pomaglumetad DMTOLI5 MI TT8A9EF DMTOLI5 MN Metabotropic glutamate receptor 3 (mGluR3) DMTOLI5 MT DTT DMTOLI5 MA Modulator DMTOLI5 RN LY-2140023, a prodrug of the group II metabotropic glutamate receptor agonist LY-404039 for the potential treatment of schizophrenia. Curr Opin Investig Drugs. 2010 Jul;11(7):833-45. DMTOLI5 RU https://pubmed.ncbi.nlm.nih.gov/20571979 DMCU54M DI DMCU54M DMCU54M DN Posiphen R-phenserine DMCU54M MI TT08OSU DMCU54M MN Synuclein alpha (SNCA) DMCU54M MT DTT DMCU54M MA Modulator DMCU54M RN The Anticholinesterase Phenserine and Its Enantiomer Posiphen as 5 ntranslated-Region-Directed Translation Blockers of the Parkinson's Alpha Synuclein Expression. Parkinson's Disease Volume 2012 (2012), Article ID 142372, Page(13). DMCU54M RU http://www.hindawi.com/journals/pd/2012/142372/ DM2D7Z0 DI DM2D7Z0 DM2D7Z0 DN PPC-5650 DM2D7Z0 MI TTRJYB6 DM2D7Z0 MN Acid-sensing ion channel 1 (ASIC1) DM2D7Z0 MT DTT DM2D7Z0 MA Modulator DM2D7Z0 RN ClinicalTrials.gov (NCT01449487) Investigation of Efficacy and Safety of PPC-5650 to Experimental Induced Sensation and Pain in the Rectosigmoid. U.S. National Institutes of Health. DM2D7Z0 RU https://clinicaltrials.gov/ct2/show/NCT01449487 DMSAQBC DI DMSAQBC DMSAQBC DN PPI-2458 DMSAQBC MI TTZL0OI DMSAQBC MN Methionine aminopeptidase 2 (METAP2) DMSAQBC MT DTT DMSAQBC MA Inhibitor DMSAQBC RN Metabolites of PPI-2458, a selective, irreversible inhibitor of methionine aminopeptidase-2: structure determination and in vivo activity. Drug Metab Dispos. 2013 Apr;41(4):814-26. DMSAQBC RU https://pubmed.ncbi.nlm.nih.gov/23355637 DMEOJUN DI DMEOJUN DMEOJUN DN PPI-383 DMEOJUN MI TTMVBWH DMEOJUN MN Hepatitis C virus RNA-directed RNA polymerase (HCV NS5B) DMEOJUN MT DTT DMEOJUN MA Inhibitor DMEOJUN RN 1173 IDENTIFICATION AND CHARACTERIZATION OF PPI-383, A NEXT GENERATION HCV NS5B NON-NUCLEOSIDE INHIBITOR WITH POTENT ACTIVITY AGAINST ALL MAJOR HCV GENOTYPES. Journal of Hepatology Volume 56, Supplement 2, April 2012, Pages S464. DMEOJUN RU http://www.sciencedirect.com/science/article/pii/S0168827812611854 DMTOXLG DI DMTOXLG DMTOXLG DN PPI-461 DMTOXLG MI TTCJ2X8 DMTOXLG MN Hepatitis C virus Non-structural 5A (HCV NS5A) DMTOXLG MT DTT DMTOXLG MA Modulator DMTOXLG RN Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41. DMTOXLG RU https://www.ncbi.nlm.nih.gov/pubmed/15950434 DMOYUPM DI DMOYUPM DMOYUPM DN PPL-100 DMOYUPM MI TT5FNQT DMOYUPM MN Human immunodeficiency virus Protease (HIV PR) DMOYUPM MT DTT DMOYUPM MA Inhibitor DMOYUPM RN Antiviral activity and cross-resistance profile of P-1946, a novel human immunodeficiency virus type 1 protease inhibitor. Antiviral Res. 2006 Jun;70(2):17-20. DMOYUPM RU https://pubmed.ncbi.nlm.nih.gov/16473417 DMY2GDQ DI DMY2GDQ DMY2GDQ DN P-PSMA-101 DMY2GDQ MI TTZ3P4W DMY2GDQ MN B-cell maturation protein (TNFRSF17) DMY2GDQ MT DTT DMY2GDQ RN Clinical pipeline report, company report or official report of Poseida Therapeutics. DMY2GDQ RU https://poseida.com/science/pipeline/#cart-therapies DMHIS3M DI DMHIS3M DMHIS3M DN PRAX-330 DMHIS3M MI TT54ERL DMHIS3M MN Voltage-gated sodium channel alpha Nav1.6 (SCN8A) DMHIS3M MT DTT DMHIS3M MA Inhibitor DMHIS3M RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMHIS3M RU http://phrma-docs.phrma.org/files/dmfile/MID_Neurological-Disorders-Drug-List_2018.pdf DMCUE71 DI DMCUE71 DMCUE71 DN PRGN-3005 DMCUE71 MI TTC1PS3 DMCUE71 MN Ovarian carcinoma antigen CA125 (MUC16) DMCUE71 MT DTT DMCUE71 RN Clinical pipeline report, company report or official report of Precigen. DMCUE71 RU https://precigen.com/pipeline/ DMR7BAO DI DMR7BAO DMR7BAO DN PRN1371 DMR7BAO MI TT0LF7H DMR7BAO MN Fibroblast growth factor receptor (FGFR) DMR7BAO MT DTT DMR7BAO MA Inhibitor DMR7BAO RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMR7BAO RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DMQNS51 DI DMQNS51 DMQNS51 DN PRN2246 DMQNS51 MI TTGM6VW DMQNS51 MN Tyrosine-protein kinase BTK (ATK) DMQNS51 MT DTT DMQNS51 MA Inhibitor DMQNS51 RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMQNS51 RU http://phrma-docs.phrma.org/files/dmfile/MID_Neurological-Disorders-Drug-List_2018.pdf DMLKF3H DI DMLKF3H DMLKF3H DN Prolanta DMLKF3H MI TTBPXMA DMLKF3H MN Prolactin receptor (PRLR) DMLKF3H MT DTT DMLKF3H MA Antagonist DMLKF3H RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMLKF3H RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DME1Y9W DI DME1Y9W DME1Y9W DN Protexia DME1Y9W MI TTEB0GD DME1Y9W MN Cholinesterase (BCHE) DME1Y9W MT DTT DME1Y9W MA Modulator DME1Y9W RN In vitro and in vivo characterization of recombinant human butyrylcholinesterase (Protexia) as a potential nerve agent bioscavenger. Chem Biol Interact. 2005 Dec 15;157-158:363-5. DME1Y9W RU https://pubmed.ncbi.nlm.nih.gov/16429486 DMBL7CW DI DMBL7CW DMBL7CW DN PRT-062607 DMBL7CW MI TTOU65C DMBL7CW MN Tyrosine-protein kinase SYK (SYK) DMBL7CW MT DTT DMBL7CW MA Inhibitor DMBL7CW RN Advances in kinase inhibition: treating rheumatic diseases and beyond. Curr Opin Rheumatol. 2014 March; 26(2): 237-243. DMBL7CW RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4106228/ DMIKE0O DI DMIKE0O DMIKE0O DN PRT1419 DMIKE0O MI TTL53M6 DMIKE0O MN Induced myeloid leukemia cell differentiation protein Mcl-1 (MCL1) DMIKE0O MT DTT DMIKE0O MA Inhibitor DMIKE0O RN Clinical pipeline report, company report or official report of Prelude Therapeutics. DMIKE0O RU https://preludetx.com/science/mcl1/prt1419/ DMHNZ3U DI DMHNZ3U DMHNZ3U DN PRT543 DMHNZ3U MI TTR1D7X DMHNZ3U MN Protein arginine methyltransferase 5 (PRMT5) DMHNZ3U MT DTT DMHNZ3U MA Inhibitor DMHNZ3U RN Clinical pipeline report, company report or official report of Prelude Therapeutics. DMHNZ3U RU https://preludetx.com/science/prmt5/prt543/ DMP5CLY DI DMP5CLY DMP5CLY DN PRT6207 DMP5CLY MI TTOU65C DMP5CLY MN Tyrosine-protein kinase SYK (SYK) DMP5CLY MT DTT DMP5CLY MA Modulator DMP5CLY RN Advances in kinase inhibition: treating rheumatic diseases and beyond. Curr Opin Rheumatol. 2014 March; 26(2): 237-243. DMP5CLY RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4106228/ DMW3MCX DI DMW3MCX DMW3MCX DN PRT811 DMW3MCX MI TTR1D7X DMW3MCX MN Protein arginine methyltransferase 5 (PRMT5) DMW3MCX MT DTT DMW3MCX MA Inhibitor DMW3MCX RN Clinical pipeline report, company report or official report of Prelude Therapeutics. DMW3MCX RU https://preludetx.com/science/prmt5/prt811/ DM5KI6X DI DM5KI6X DM5KI6X DN PRX003 DM5KI6X MI TTD26RC DM5KI6X MN Cell adhesion molecule (CADM) DM5KI6X MT DTT DM5KI6X MA Inhibitor DM5KI6X RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DM5KI6X RU http://phrma-docs.phrma.org/files/dmfile/medicines-in-development-drug-list-autoimmune-diseases.pdf DM5TLAP DI DM5TLAP DM5TLAP DN PRX-07034 DM5TLAP MI TTJS8PY DM5TLAP MN 5-HT 6 receptor (HTR6) DM5TLAP MT DTT DM5TLAP MA Antagonist DM5TLAP RN Low-dose prazosin in combination with 5-HT6 antagonist PRX-07034 has antipsychotic effects. Can J Physiol Pharmacol. 2015 Jan;93(1):13-21. DM5TLAP RU https://pubmed.ncbi.nlm.nih.gov/25429515 DMWT8RI DI DMWT8RI DMWT8RI DN PRX-105 DMWT8RI MI TT1RS9F DMWT8RI MN Acetylcholinesterase (AChE) DMWT8RI MT DTT DMWT8RI MA Inhibitor DMWT8RI RN Preclinical and first-in-human evaluation of PRX-105, a PEGylated, plant-derived, recombinant human acetylcholinesterase-R. Toxicol Appl Pharmacol. 2015 Sep 15;287(3):202-9. DMWT8RI RU https://pubmed.ncbi.nlm.nih.gov/26051873 DM2594H DI DM2594H DM2594H DN PS-178990 DM2594H MI TTS64P2 DM2594H MN Androgen receptor (AR) DM2594H MT DTT DM2594H MA Binder DM2594H RN Selective androgen receptor modulators in preclinical and clinical development. Nucl Recept Signal. 2008; 6: e010. DM2594H RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2602589/ DM75FWO DI DM75FWO DM75FWO DN PSI-697 DM75FWO MI TTE5VG0 DM75FWO MN P-selectin (SELP) DM75FWO MT DTT DM75FWO MA Inhibitor DM75FWO RN Effect of PSI-697, a novel P-selectin inhibitor, on platelet-monocyte aggregate formation in humans. J Am Heart Assoc. 2013 Jan 28;2(1):e006007. DM75FWO RU https://pubmed.ncbi.nlm.nih.gov/23525448 DM5ZR4Q DI DM5ZR4Q DM5ZR4Q DN PSI-938 DM5ZR4Q MI TTMVBWH DM5ZR4Q MN Hepatitis C virus RNA-directed RNA polymerase (HCV NS5B) DM5ZR4Q MT DTT DM5ZR4Q MA Inhibitor DM5ZR4Q RN 2011 Pipeline of Pharmasset. DM5ZR4Q RU http://www.pharmasset.com/pipeline/default.aspx DM8Y1M9 DI DM8Y1M9 DM8Y1M9 DN PSMA CAR-T cell therapy DM8Y1M9 MI TT9G4N0 DM8Y1M9 MN Glutamate carboxypeptidase II (GCPII) DM8Y1M9 MT DTT DM8Y1M9 RN Clinical pipeline report, company report or official report of Tmunity. DM8Y1M9 RU https://www.tmunity.com/pipeline DMRHQTU DI DMRHQTU DMRHQTU DN PSMA subunit vaccine DMRHQTU MI TT9G4N0 DMRHQTU MN Glutamate carboxypeptidase II (GCPII) DMRHQTU MT DTT DMRHQTU RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1606). DMRHQTU RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1606 DMOYX6W DI DMOYX6W DMOYX6W DN PSMA-targeted tubulysin B conjugates DMOYX6W MI TT9G4N0 DMOYX6W MN Glutamate carboxypeptidase II (GCPII) DMOYX6W MT DTT DMOYX6W MA Modulator DMOYX6W RN Prostate-specific membrane antigen targeted imaging and therapy of prostate cancer using a PSMA inhibitor as a homing ligand. Mol Pharm. 2009 May-Jun;6(3):780-9. DMOYX6W RU https://pubmed.ncbi.nlm.nih.gov/19361233 DM03O8T DI DM03O8T DM03O8T DN PSMA-VRP DM03O8T MI TT9G4N0 DM03O8T MN Glutamate carboxypeptidase II (GCPII) DM03O8T MT DTT DM03O8T RN A phase I dose escalation trial of vaccine replicon particles (VRP) expressing prostate-specific membrane antigen (PSMA) in subjects with prostate cancer. Vaccine. 2013 Jan 30;31(6):943-9. DM03O8T RU https://pubmed.ncbi.nlm.nih.gov/23246260 DMB6M1P DI DMB6M1P DMB6M1P DN PT-112 DMB6M1P MI TT84ETX DMB6M1P MN Human immunodeficiency virus Reverse transcriptase (HIV RT) DMB6M1P MT DTT DMB6M1P MA Inhibitor DMB6M1P RN Phenethylthiazolylthiourea (PETT) compounds as a new class of HIV-1 reverse transcriptase inhibitors. 2. Synthesis and further structure-activity r... J Med Chem. 1996 Oct 11;39(21):4261-74. DMB6M1P RU https://pubmed.ncbi.nlm.nih.gov/8863804 DMWBA1S DI DMWBA1S DMWBA1S DN PT-302 DMWBA1S MI TT84ETX DMWBA1S MN Human immunodeficiency virus Reverse transcriptase (HIV RT) DMWBA1S MT DTT DMWBA1S MA Inhibitor DMWBA1S RN Phenethylthiazolethiourea (PETT) compounds, a new class of HIV-1 reverse transcriptase inhibitors. 1. Synthesis and basic structure-activity relati... J Med Chem. 1995 Dec 8;38(25):4929-36. DMWBA1S RU https://pubmed.ncbi.nlm.nih.gov/8523406 DMQNRGE DI DMQNRGE DMQNRGE DN PTG-100 DMQNRGE MI TT4BT06 DMQNRGE MN Integrin alpha-4 (ITGA4) DMQNRGE MT DTT DMQNRGE MA Antagonist DMQNRGE RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMQNRGE RU http://phrma-docs.phrma.org/files/dmfile/medicines-in-development-drug-list-autoimmune-diseases.pdf DMQNRGE DI DMQNRGE DMQNRGE DN PTG-100 DMQNRGE MI TTLT9XQ DMQNRGE MN Integrin beta-7 (ITGB7) DMQNRGE MT DTT DMQNRGE MA Antagonist DMQNRGE RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMQNRGE RU http://phrma-docs.phrma.org/files/dmfile/medicines-in-development-drug-list-autoimmune-diseases.pdf DMRQ5YT DI DMRQ5YT DMRQ5YT DN PTH(7-34) liposomal cream DMRQ5YT MI TTEPJL5 DMRQ5YT MN Parathyroid hormone receptor (PTH2R) DMRQ5YT MT DTT DMRQ5YT MA Modulator DMRQ5YT RN Differential effects of intermittent PTH(1-34) and PTH(7-34) on bone microarchitecture and aortic calcification in experimental renal failure. Bone. 2008 Dec;43(6):1022-30. DMRQ5YT RU https://pubmed.ncbi.nlm.nih.gov/18761112 DMV5X8M DI DMV5X8M DMV5X8M DN PTI-125 DMV5X8M MI TTSTRZY DMV5X8M MN Filamin A (FLNA) DMV5X8M MT DTT DMV5X8M MA Inhibitor DMV5X8M RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMV5X8M RU http://phrma-docs.phrma.org/files/dmfile/MID_Neurological-Disorders-Drug-List_2018.pdf DMNO91Q DI DMNO91Q DMNO91Q DN PTI-202 DMNO91Q MI TTN4QDT DMNO91Q MN Opioid receptor (OPR) DMNO91Q MT DTT DMNO91Q MA Modulator DMNO91Q RN Clinical pipeline report, company report or official report of Pain Therapeutics, Inc. DMNO91Q RU http://www.paintrials.com/pti-202.html DM0A6N9 DI DM0A6N9 DM0A6N9 DN PTI-80 DM0A6N9 MI TTS87KH DM0A6N9 MN Microtubule-associated protein tau (MAPT) DM0A6N9 MT DTT DM0A6N9 MA Inhibitor DM0A6N9 RN Biopharmaceutical Research Companies Are Developing More Than 430 Medicines for Top Chronic Diseases Affecting Older Americans. Pharmaceutical Research and Manufacturers of America report. 2014. DM0A6N9 RU http://www.phrma.org/sites/default/files/pdf/2014-meds-in-dev-older-americans.pdf DMAWO5I DI DMAWO5I DMAWO5I DN PTX-100 DMAWO5I MI TT4P2VW DMAWO5I MN Geranylgeranyl transferase (GGTase) DMAWO5I MT DTT DMAWO5I MA Inhibitor DMAWO5I RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMAWO5I RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DM38F50 DI DM38F50 DM38F50 DN PTX-35 DM38F50 MI TTDV6BQ DM38F50 MN Tumor necrosis factor receptor member 25 (TNFRSF25) DM38F50 MT DTT DM38F50 MA Agonist DM38F50 RN Clinical pipeline report, company report or official report of Pelican Therapeutics. DM38F50 RU https://www.pelicantherapeutics.com/products DMJO0BP DI DMJO0BP DMJO0BP DN PU3 DMJO0BP MI TT78R5H DMJO0BP MN Heat shock protein 90 alpha (HSP90A) DMJO0BP MT DTT DMJO0BP MA Inhibitor DMJO0BP RN Recent advances in Hsp90 inhibitors as antitumor agents. Anticancer Agents Med Chem. 2008 Oct;8(7):761-82. DMJO0BP RU https://pubmed.ncbi.nlm.nih.gov/18855578 DMKSU35 DI DMKSU35 DMKSU35 DN PU-AD DMKSU35 MI TT78R5H DMKSU35 MN Heat shock protein 90 alpha (HSP90A) DMKSU35 MT DTT DMKSU35 MA Inhibitor DMKSU35 RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMKSU35 RU http://phrma-docs.phrma.org/files/dmfile/MID_Neurological-Disorders-Drug-List_2018.pdf DMIYHAW DI DMIYHAW DMIYHAW DN PU-H71 DMIYHAW MI TTH5YN2 DMIYHAW MN Heat shock protein 90 beta (HSP90B) DMIYHAW MT DTT DMIYHAW MA Inhibitor DMIYHAW RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMIYHAW RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DMX5LB7 DI DMX5LB7 DMX5LB7 DN PUR0200 DMX5LB7 MI TTOXS3C DMX5LB7 MN Muscarinic acetylcholine receptor (CHRM) DMX5LB7 MT DTT DMX5LB7 MA Modulator DMX5LB7 RN Clinical pipeline report, company report or official report of pulmatrix pipeline. DMX5LB7 RU http://pulmatrix.com/pipeline.html DMJY15D DI DMJY15D DMJY15D DN PWT-33597 DMJY15D MI TTEUNMR DMJY15D MN PI3-kinase alpha (PIK3CA) DMJY15D MT DTT DMJY15D MA Modulator DMJY15D RN Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41. DMJY15D RU https://www.ncbi.nlm.nih.gov/pubmed/15950434 DMJY15D DI DMJY15D DMJY15D DN PWT-33597 DMJY15D MI TTCJG29 DMJY15D MN Serine/threonine-protein kinase mTOR (mTOR) DMJY15D MT DTT DMJY15D MA Modulator DMJY15D RN PIK3CA mutation H1047R is associated with response to PI3K/AKT/mTOR signaling pathway inhibitors in early phase clinical trials DMJY15D RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3537862 DMWU682 DI DMWU682 DMWU682 DN PX-102 DMWU682 MI TTS4UGC DMWU682 MN Farnesoid X-activated receptor (FXR) DMWU682 MT DTT DMWU682 MA Agonist DMWU682 RN An FXR Agonist Reduces Bile Acid Synthesis Independently of Increases in FGF19 in Healthy Volunteers. Gastroenterology. 2018 Oct;155(4):1012-1016. DMWU682 RU https://pubmed.ncbi.nlm.nih.gov/29928896 DM4AU8K DI DM4AU8K DM4AU8K DN PX-478 DM4AU8K MI TTQHWNA DM4AU8K MN Hypoxia-inducible factor 1 alpha (HIF-1A) DM4AU8K MT DTT DM4AU8K MA Inhibitor DM4AU8K RN The selective hypoxia inducible factor-1 inhibitor PX-478 provides in vivo radiosensitization through tumor stromal effects. Mol Cancer Ther. 2009 Apr;8(4):947-58. DM4AU8K RU https://pubmed.ncbi.nlm.nih.gov/19372568 DMVQJOS DI DMVQJOS DMVQJOS DN PXS-25 DMVQJOS MI TTPNE41 DMVQJOS MN CI Man-6-P receptor (IGF2R) DMVQJOS MT DTT DMVQJOS MA Inhibitor DMVQJOS RN Cation-independent mannose 6-phosphate receptor inhibitor (PXS25) inhibits fibrosis in human proximal tubular cells by inhibiting conversion of latent to active TGF-beta1. Am J Physiol Renal Physiol.2011 Jul;301(1):F84-93. DMVQJOS RU https://pubmed.ncbi.nlm.nih.gov/21478477 DMW7K39 DI DMW7K39 DMW7K39 DN Pyrotinib DMW7K39 MI TTG96HZ DMW7K39 MN EGFR messenger RNA (EGFR mRNA) DMW7K39 MT DTT DMW7K39 MA Inhibitor DMW7K39 RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMW7K39 RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DMRGWDB DI DMRGWDB DMRGWDB DN PZ01 CAR-T cells DMRGWDB MI TTW640A DMRGWDB MN B-lymphocyte surface antigen B4 (CD19) DMRGWDB MT DTT DMRGWDB MA CAR-T-Cell-Therapy DMRGWDB RN ClinicalTrials.gov (NCT03281551) Efficacy and Safety of PZ01 Treatment in Patients With r/r CD19+ B-cell Acute Lymphoblastic Leukemia/B Cell Lymphoma DMRGWDB RU https://clinicaltrials.gov/ct2/show/NCT03281551 DMP3QSA DI DMP3QSA DMP3QSA DN Quinazoline derivative 9 DMP3QSA MI TTQFRP0 DMP3QSA MN MEK kinase kinase 2 (MAP4K2) DMP3QSA MT DTT DMP3QSA MA Inhibitor DMP3QSA RN Cyclin-dependent kinase inhibitors for cancer therapy: a patent review (2009 - 2014).Expert Opin Ther Pat. 2015;25(9):953-70. DMP3QSA RU https://www.ncbi.nlm.nih.gov/pubmed/26161698 DMP3QSA DI DMP3QSA DMP3QSA DN Quinazoline derivative 9 DMP3QSA MI TTRHJA3 DMP3QSA MN SPS1/STE20-related protein kinase YSK4 (YSK4) DMP3QSA MT DTT DMP3QSA MA Inhibitor DMP3QSA RN Cyclin-dependent kinase inhibitors for cancer therapy: a patent review (2009 - 2014).Expert Opin Ther Pat. 2015;25(9):953-70. DMP3QSA RU https://www.ncbi.nlm.nih.gov/pubmed/26161698 DM64U1Y DI DM64U1Y DM64U1Y DN R-1663 DM64U1Y MI TTCIHJA DM64U1Y MN Coagulation factor Xa (F10) DM64U1Y MT DTT DM64U1Y MA Inhibitor DM64U1Y RN Semuloparin for the prevention of venous thromboembolic events in cancer patients. Drugs Today (Barc). 2012 Jul;48(7):451-7. DM64U1Y RU https://pubmed.ncbi.nlm.nih.gov/22844656 DMSKHIC DI DMSKHIC DMSKHIC DN R4996 DMSKHIC MI TTLA931 DMSKHIC MN Neuronal acetylcholine receptor alpha-7 (CHRNA7) DMSKHIC MT DTT DMSKHIC MA Agonist DMSKHIC RN Clinical pipeline report, company report or official report of Roche (2009). DMSKHIC RU http://www.roche.com/research_and_development/pipeline/roche_pharma_pipeline.htm DM5XCRQ DI DM5XCRQ DM5XCRQ DN R552 DM5XCRQ MI TTAIQSN DM5XCRQ MN Receptor-interacting protein 1 (RIPK1) DM5XCRQ MT DTT DM5XCRQ MA Inhibitor DM5XCRQ RN Receptor-interacting protein kinase 1 (RIPK1) as a therapeutic target. Nat Rev Drug Discov. 2020 Aug;19(8):553-571. DM5XCRQ RU https://pubmed.ncbi.nlm.nih.gov/32669658 DMVA186 DI DMVA186 DMVA186 DN R7334 DMVA186 MI TT48I1Y DMVA186 MN Placenta growth factor (PlGF) DMVA186 MT DTT DMVA186 RN Clinical pipeline report, company report or official report of Roche (2009). DMVA186 RU http://www.roche.com/research_and_development/pipeline/roche_pharma_pipeline.htm DME0CJ9 DI DME0CJ9 DME0CJ9 DN R763 DME0CJ9 MI TTPS3C0 DME0CJ9 MN Aurora kinase A (AURKA) DME0CJ9 MT DTT DME0CJ9 MA Inhibitor DME0CJ9 RN Preclinical characterization of Aurora kinase inhibitor R763/AS703569 identified through an image-based phenotypic screen. J Cancer Res Clin Oncol. 2010 Jan;136(1):99-113. DME0CJ9 RU https://pubmed.ncbi.nlm.nih.gov/19609559 DME0CJ9 DI DME0CJ9 DME0CJ9 DN R763 DME0CJ9 MI TT5LS6T DME0CJ9 MN Aurora kinase B (AURKB) DME0CJ9 MT DTT DME0CJ9 MA Inhibitor DME0CJ9 RN Preclinical characterization of Aurora kinase inhibitor R763/AS703569 identified through an image-based phenotypic screen. J Cancer Res Clin Oncol. 2010 Jan;136(1):99-113. DME0CJ9 RU https://pubmed.ncbi.nlm.nih.gov/19609559 DM1N8PZ DI DM1N8PZ DM1N8PZ DN rAAV1.tMCK.human-alpha-sarcoglycan DM1N8PZ MI TTS9Q5V DM1N8PZ MN Sarcoglycan alpha (SGCA) DM1N8PZ MT DTT DM1N8PZ MA Modulator DM1N8PZ RN Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41. DM1N8PZ RU https://www.ncbi.nlm.nih.gov/pubmed/15950434 DMNVDI2 DI DMNVDI2 DMNVDI2 DN RAD-140 DMNVDI2 MI TTS64P2 DMNVDI2 MN Androgen receptor (AR) DMNVDI2 MT DTT DMNVDI2 MA Modulator DMNVDI2 RN Design, Synthesis, and Preclinical Characterization of the Selective Androgen Receptor Modulator (SARM) RAD140. ACS Med Chem Lett. 2010 Dec 2;2(2):124-9. DMNVDI2 RU https://pubmed.ncbi.nlm.nih.gov/24900290 DMIEJ0W DI DMIEJ0W DMIEJ0W DN Radiolabelled-huA33 DMIEJ0W MI TT96HUR DMIEJ0W MN Cell surface A33 antigen (GPA33) DMIEJ0W MT DTT DMIEJ0W RN (124)I-huA33 antibody PET of colorectal cancer. J Nucl Med. 2011 Aug;52(8):1173-80. DMIEJ0W RU https://pubmed.ncbi.nlm.nih.gov/21764796 DM4VTX6 DI DM4VTX6 DM4VTX6 DN RASV-Sp DM4VTX6 MI TTHI19T DM4VTX6 MN Staphylococcus Beta-lactamase (Stap-coc blaZ) DM4VTX6 MT DTT DM4VTX6 RN WO patent application no. 2010,0456,20, Recombinant bacterium capable of eliciting an immune response against streptococcus pneumoniae. DM4VTX6 RU http://worldwide.espacenet.com/publicationDetails/biblio?DB=worldwide.espacenet.com&II=0&ND=3&adjacent=true&locale=en_EP&FT=D&date=20100422&CC=WO&NR=2010045620A1&KC=A1 DMAP6CS DI DMAP6CS DMAP6CS DN RBN-2397 DMAP6CS MI TT2FRAN DMAP6CS MN Protein mono-ADP-ribosyltransferase TIPARP (TIPARP) DMAP6CS MT DTT DMAP6CS MA Inhibitor DMAP6CS RN Clinical pipeline report, company report or official report of Ribon Therapeutics. DMAP6CS RU https://ribontx.com/rbn-2397/ DM25GIA DI DM25GIA DM25GIA DN REC-01 DM25GIA MI TTDIGC1 DM25GIA MN Dipeptidyl peptidase 4 (DPP-4) DM25GIA MT DTT DM25GIA MA Inhibitor DM25GIA RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DM25GIA RU http://phrma-docs.phrma.org/files/dmfile/2018_Heart-Disease-and-Stroke_MID-Drug-List.pdf DMHT5XV DI DMHT5XV DMHT5XV DN REC-02 DMHT5XV MI TT4UGTF DMHT5XV MN Stromal cell-derived factor 1 (CXCL12) DMHT5XV MT DTT DMHT5XV MA Modulator DMHT5XV RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMHT5XV RU http://phrma-docs.phrma.org/files/dmfile/2018_Heart-Disease-and-Stroke_MID-Drug-List.pdf DMK9Y71 DI DMK9Y71 DMK9Y71 DN Recombinant human Erbb3 fragment therapeutic tumor vaccine DMK9Y71 MI TT6EO5L DMK9Y71 MN Erbb2 tyrosine kinase receptor (HER2) DMK9Y71 MT DTT DMK9Y71 RN Clinical pipeline report, company report or official report of Zensun. DMK9Y71 RU http://www.zensunusa.com/research/ DMK9Y71 DI DMK9Y71 DMK9Y71 DN Recombinant human Erbb3 fragment therapeutic tumor vaccine DMK9Y71 MI TTDC8N2 DMK9Y71 MN Erbb3 tyrosine kinase receptor (Erbb-3) DMK9Y71 MT DTT DMK9Y71 RN Clinical pipeline report, company report or official report of Zensun. DMK9Y71 RU http://www.zensunusa.com/research/ DMYBELW DI DMYBELW DMYBELW DN REGN1193 DMYBELW MI TT9O6WS DMYBELW MN Glucagon receptor (GCGR) DMYBELW MT DTT DMYBELW MA Blocker DMYBELW RN A first-in-human pharmacodynamic and pharmacokinetic study of a fully human anti-glucagon receptor monoclonal antibody in normal healthy volunteers. Diabetes Obes Metab. 2018 Feb;20(2):283-291. DMYBELW RU https://pubmed.ncbi.nlm.nih.gov/28755409 DME3VU8 DI DME3VU8 DME3VU8 DN REGN1400 DME3VU8 MI TTDC8N2 DME3VU8 MN Erbb3 tyrosine kinase receptor (Erbb-3) DME3VU8 MT DTT DME3VU8 RN J Clin Oncol 32:5s, 2014 (suppl; abstr 2516). DME3VU8 RU http://meetinglibrary.asco.org/content/131992-144 DM0E3ZG DI DM0E3ZG DM0E3ZG DN REGN3048 DM0E3ZG MI TTZ3COY DM0E3ZG MN COVID-19 spike glycoprotein (S) DM0E3ZG MT DTT DM0E3ZG MA Inhibitor DM0E3ZG RN Prophylactic and therapeutic efficacy of mAb treatment against MERS-CoV in common marmosets. Antiviral Res. 2018 Aug;156:64-71. DM0E3ZG RU https://pubmed.ncbi.nlm.nih.gov/29885377 DM7LIV2 DI DM7LIV2 DM7LIV2 DN REGN3051 DM7LIV2 MI TTZ3COY DM7LIV2 MN COVID-19 spike glycoprotein (S) DM7LIV2 MT DTT DM7LIV2 MA Inhibitor DM7LIV2 RN Prophylactic and therapeutic efficacy of mAb treatment against MERS-CoV in common marmosets. Antiviral Res. 2018 Aug;156:64-71. DM7LIV2 RU https://pubmed.ncbi.nlm.nih.gov/29885377 DMWJ0IH DI DMWJ0IH DMWJ0IH DN REGN-421 DMWJ0IH MI TTV23LH DMWJ0IH MN Delta-like protein 4 (DLL4) DMWJ0IH MT DTT DMWJ0IH RN J Clin Oncol 31, 2013 (suppl; abstr 2502). DMWJ0IH RU http://meetinglibrary.asco.org/content/113836-132 DM3720L DI DM3720L DM3720L DN REGN5093 DM3720L MI TTNDSF4 DM3720L MN Proto-oncogene c-Met (MET) DM3720L MT DTT DM3720L MA Inhibitor DM3720L RN Clinical pipeline report, company report or official report of Regeneron Pharmaceuticals. DM3720L RU https://www.regeneron.com/science/pipeline DM0ZMNI DI DM0ZMNI DM0ZMNI DN REGN6569 DM0ZMNI MI TTG6LA7 DM0ZMNI MN Activation-inducible TNFR family receptor (TNFRSF18) DM0ZMNI MT DTT DM0ZMNI MA Inhibitor DM0ZMNI RN Clinical pipeline report, company report or official report of Regeneron Pharmaceuticals. DM0ZMNI RU https://www.regeneron.com/science/pipeline DMHR7D4 DI DMHR7D4 DMHR7D4 DN REGN-910 DMHR7D4 MI TTKLQTJ DMHR7D4 MN Angiopoietin-2 (ANGPT2) DMHR7D4 MT DTT DMHR7D4 RN Angiopoietin-2 functions as a Tie2 agonist in tumor models, where it limits the effects of VEGF inhibition. Cancer Res. 2013 Jan 1;73(1):108-18. DMHR7D4 RU https://pubmed.ncbi.nlm.nih.gov/23149917 DMZJH23 DI DMZJH23 DMZJH23 DN REP8839 DMZJH23 MI TTOJ46K DMZJH23 MN Streptococcus Methionyl-tRNA synthetase (Stre-coc metG) DMZJH23 MT DTT DMZJH23 MA Inhibitor DMZJH23 RN Antibacterial activity of REP8839, a new antibiotic for topical use. Antimicrob Agents Chemother. 2005 Oct;49(10):4247-52. DMZJH23 RU https://pubmed.ncbi.nlm.nih.gov/16189105 DMZ8WAQ DI DMZ8WAQ DMZ8WAQ DN Retroviral vector-transduced autologous T cells to express CD22-specific CARs DMZ8WAQ MI TTM6QSK DMZ8WAQ MN B-cell receptor CD22 (CD22) DMZ8WAQ MT DTT DMZ8WAQ MA CAR-T-Cell-Therapy DMZ8WAQ RN ClinicalTrials.gov (NCT02721407) Anti-CD22 CAR-T Therapy for CD19-refractory or Resistant Lymphoma Patients DMZ8WAQ RU https://clinicaltrials.gov/ct2/show/NCT02721407 DMLHIMO DI DMLHIMO DMLHIMO DN REV-576 DMLHIMO MI TTKANGO DMLHIMO MN Complement C5 (CO5) DMLHIMO MT DTT DMLHIMO MA Inhibitor DMLHIMO RN Complement C5-inhibitor rEV576 (coversin) ameliorates in-vivo effects of antiphospholipid antibodies. Lupus. 2014 Oct;23(12):1324-6. DMLHIMO RU https://pubmed.ncbi.nlm.nih.gov/25228739 DM7B650 DI DM7B650 DM7B650 DN RG-2833 DM7B650 MI TT6R7JZ DM7B650 MN Histone deacetylase 1 (HDAC1) DM7B650 MT DTT DM7B650 MA Modulator DM7B650 RN Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41. DM7B650 RU https://www.ncbi.nlm.nih.gov/pubmed/15950434 DM8GC65 DI DM8GC65 DM8GC65 DN RG3039 DM8GC65 MI TTLSW9V DM8GC65 MN Scavenger decapping enzyme DcpS (DCPS) DM8GC65 MT DTT DM8GC65 MA Inhibitor DM8GC65 RN 2011 Pipeline of Repligen. DM8GC65 RU http://www.repligen.com/products/pipeline DM45HT6 DI DM45HT6 DM45HT6 DN RG6062 DM45HT6 MI TTUE541 DM45HT6 MN Leukocyte surface antigen Leu-16 (CD20) DM45HT6 MT DTT DM45HT6 MA Modulator DM45HT6 RN Glofitamab, a Novel, Bivalent CD20-Targeting T-Cell-Engaging Bispecific Antibody, Induces Durable Complete Remissions in Relapsed or Refractory B-Cell Lymphoma: A Phase I Trial. J Clin Oncol. 2021 Jun 20;39(18):1959-1970. DM45HT6 RU https://pubmed.ncbi.nlm.nih.gov/33739857 DMO9BGI DI DMO9BGI DMO9BGI DN RG6076 DMO9BGI MI TTPW9LJ DMO9BGI MN Co-stimulatory molecule 4-1BB (CD137) DMO9BGI MT DTT DMO9BGI RN Clinical pipeline report, company report or official report of Roche. DMO9BGI RU https://www.roche.com/research_and_development/who_we_are_how_we_work/pipeline.htm DM9QNMB DI DM9QNMB DM9QNMB DN RG6084 DM9QNMB MI TTFAOU7 DM9QNMB MN CD274 messenger RNA (CD274 mRNA) DM9QNMB MT DTT DM9QNMB MA Inhibitor DM9QNMB RN Clinical pipeline report, company report or official report of Roche. DM9QNMB RU https://www.roche.com/research_and_development/who_we_are_how_we_work/pipeline.htm DM6TLPD DI DM6TLPD DM6TLPD DN RG6115 DM6TLPD MI TTRJ1K4 DM6TLPD MN Toll-like receptor 7 (TLR7) DM6TLPD MT DTT DM6TLPD MA Agonist DM6TLPD RN Clinical pipeline report, company report or official report of Roche. DM6TLPD RU https://www.roche.com/research_and_development/who_we_are_how_we_work/pipeline.htm DMX8YO1 DI DMX8YO1 DMX8YO1 DN RG6125 DMX8YO1 MI TTRGWZC DMX8YO1 MN Osteoblast cadherin (CDH11) DMX8YO1 MT DTT DMX8YO1 MA Inhibitor DMX8YO1 RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMX8YO1 RU http://phrma-docs.phrma.org/files/dmfile/medicines-in-development-drug-list-autoimmune-diseases.pdf DMJFM3O DI DMJFM3O DMJFM3O DN RG6139 DMJFM3O MI TTNVXAW DMJFM3O MN Lymphocyte activation gene 3 protein (LAG3) DMJFM3O MT DTT DMJFM3O MA Inhibitor DMJFM3O RN Clinical pipeline report, company report or official report of Genentech. DMJFM3O RU https://www.genentechoncology.com/pipeline-molecules/pd-1-x-lag3.html DMJFM3O DI DMJFM3O DMJFM3O DN RG6139 DMJFM3O MI TTNBFWK DMJFM3O MN Programmed cell death protein 1 (PD-1) DMJFM3O MT DTT DMJFM3O MA Inhibitor DMJFM3O RN Clinical pipeline report, company report or official report of Genentech. DMJFM3O RU https://www.genentechoncology.com/pipeline-molecules/pd-1-x-lag3.html DMIHC4R DI DMIHC4R DMIHC4R DN RG6146 DMIHC4R MI TTE4BSY DMIHC4R MN Bromodomain and extraterminal domain protein (BET) DMIHC4R MT DTT DMIHC4R MA Inhibitor DMIHC4R RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMIHC4R RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DMSM0IJ DI DMSM0IJ DMSM0IJ DN RG6279 DMSM0IJ MI TTNBFWK DMSM0IJ MN Programmed cell death protein 1 (PD-1) DMSM0IJ MT DTT DMSM0IJ RN Clinical pipeline report, company report or official report of Roche. DMSM0IJ RU https://www.roche.com/research_and_development/who_we_are_how_we_work/pipeline.htm DMBRYZ7 DI DMBRYZ7 DMBRYZ7 DN RG6292 DMBRYZ7 MI TT10Y9E DMBRYZ7 MN Interleukin 2 receptor alpha (IL2RA) DMBRYZ7 MT DTT DMBRYZ7 MA Inhibitor DMBRYZ7 RN Clinical pipeline report, company report or official report of Roche. DMBRYZ7 RU https://www.roche.com/research_and_development/who_we_are_how_we_work/pipeline.htm DMEFUSJ DI DMEFUSJ DMEFUSJ DN RG6296 DMEFUSJ MI TTZ3P4W DMEFUSJ MN B-cell maturation protein (TNFRSF17) DMEFUSJ MT DTT DMEFUSJ MA Inhibitor DMEFUSJ RN Clinical pipeline report, company report or official report of Genentech. DMEFUSJ RU https://www.genentechoncology.com/pipeline-molecules/bcma-x-cd16a.html DMEFUSJ DI DMEFUSJ DMEFUSJ DN RG6296 DMEFUSJ MI TTIFOC0 DMEFUSJ MN Immunoglobulin gamma Fc receptor IIIA (FCGR3A) DMEFUSJ MT DTT DMEFUSJ MA Inhibitor DMEFUSJ RN Clinical pipeline report, company report or official report of Genentech. DMEFUSJ RU https://www.genentechoncology.com/pipeline-molecules/bcma-x-cd16a.html DMSX5NJ DI DMSX5NJ DMSX5NJ DN RG6330 DMSX5NJ MI TT3LH46 DMSX5NJ MN KRAS G12C mutant (KRAS G12C) DMSX5NJ MT DTT DMSX5NJ MA Inhibitor DMSX5NJ RN Clinical pipeline report, company report or official report of Roche. DMSX5NJ RU https://www.roche.com/research_and_development/who_we_are_how_we_work/pipeline.htm DMOWYKS DI DMOWYKS DMOWYKS DN RG6346 DMOWYKS MI TTSJVOI DMOWYKS MN Hepatitis B virus Large envelope protein messenger RNA (HBV S mRNA) DMOWYKS MT DTT DMOWYKS MA Inhibitor DMOWYKS RN Clinical pipeline report, company report or official report of Dicerna Pharmaceuticals. DMOWYKS RU https://dicerna.com/pipeline/rg6346/ DMMWS3O DI DMMWS3O DMMWS3O DN RG-7010 DMMWS3O MI TTHRID2 DMMWS3O MN Insulin-like growth factor I receptor (IGF1R) DMMWS3O MT DTT DMMWS3O MA Modulator DMMWS3O RN Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800031207) DMMWS3O RU http://adisinsight.springer.com/drugs/800031207 DM2IDQ9 DI DM2IDQ9 DM2IDQ9 DN RG-7103 DM2IDQ9 MI TT4O5P0 DM2IDQ9 MN Helodermin-preferring VIP receptor (VIPR2) DM2IDQ9 MT DTT DM2IDQ9 MA Agonist DM2IDQ9 RN Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800027925) DM2IDQ9 RU http://adisinsight.springer.com/drugs/800027925 DM6XVCO DI DM6XVCO DM6XVCO DN RG7116 DM6XVCO MI TTDC8N2 DM6XVCO MN Erbb3 tyrosine kinase receptor (Erbb-3) DM6XVCO MT DTT DM6XVCO MA Modulator DM6XVCO RN RG7116, a therapeutic antibody that binds the inactive HER3 receptor and is optimized for immune effector activation. Cancer Res. 2013 Aug 15;73(16):5183-94. DM6XVCO RU https://pubmed.ncbi.nlm.nih.gov/23780344 DMTWSM2 DI DMTWSM2 DMTWSM2 DN RG7129 DMTWSM2 MI TT8JRS7 DMTWSM2 MN Beta-secretase (BACE) DMTWSM2 MT DTT DMTWSM2 MA Modulator DMTWSM2 RN BACE1 inhibitor drugs in clinical trials for Alzheimer's disease. Alzheimers Res Ther. 2014 Dec 24;6(9):89. DMTWSM2 RU https://pubmed.ncbi.nlm.nih.gov/25621019 DMYX4NP DI DMYX4NP DMYX4NP DN RG7203 DMYX4NP MI TTJW4LU DMYX4NP MN Phosphodiesterase 10A (PDE10) DMYX4NP MT DTT DMYX4NP MA Inhibitor DMYX4NP RN Synaptic synopsis. SciBX 6(41); doi:10.1038/scibx.2013.1153. Oct. 24, 2013 DMYX4NP RU http://www.nature.com/scibx/journal/v6/n41/pdf/scibx.2013.1153.pdf?WT.ec_id=SCIBX-20131024 DMGFAVQ DI DMGFAVQ DMGFAVQ DN RG7304 DMGFAVQ MI TT5TURO DMGFAVQ MN A-Raf messenger RNA (ARAF mRNA) DMGFAVQ MT DTT DMGFAVQ MA Inhibitor DMGFAVQ RN Clinical pipeline report, company report or official report of Roche. DMGFAVQ RU http://www.roche.com/research_and_development/who_we_are_how_we_work/pipeline.htm DMGFAVQ DI DMGFAVQ DMGFAVQ DN RG7304 DMGFAVQ MI TT0EOB8 DMGFAVQ MN B-Raf messenger RNA (BRAF mRNA) DMGFAVQ MT DTT DMGFAVQ MA Inhibitor DMGFAVQ RN Clinical pipeline report, company report or official report of Roche. DMGFAVQ RU http://www.roche.com/research_and_development/who_we_are_how_we_work/pipeline.htm DMGFAVQ DI DMGFAVQ DMGFAVQ DN RG7304 DMGFAVQ MI TTZCRP3 DMGFAVQ MN ERK activator kinase (MEK) DMGFAVQ MT DTT DMGFAVQ MA Modulator DMGFAVQ RN Clinical pipeline report, company report or official report of Roche. DMGFAVQ RU http://www.roche.com/research_and_development/who_we_are_how_we_work/pipeline.htm DMGFAVQ DI DMGFAVQ DMGFAVQ DN RG7304 DMGFAVQ MI TTROQ37 DMGFAVQ MN MAPK/ERK kinase kinase (MAP3K) DMGFAVQ MT DTT DMGFAVQ MA Inhibitor DMGFAVQ RN Clinical pipeline report, company report or official report of Roche. DMGFAVQ RU http://www.roche.com/research_and_development/who_we_are_how_we_work/pipeline.htm DMGFAVQ DI DMGFAVQ DMGFAVQ DN RG7304 DMGFAVQ MI TT1EDJZ DMGFAVQ MN Microtubule-associated protein (MAP) DMGFAVQ MT DTT DMGFAVQ MA Modulator DMGFAVQ RN Clinical pipeline report, company report or official report of Roche. DMGFAVQ RU http://www.roche.com/research_and_development/who_we_are_how_we_work/pipeline.htm DMGFAVQ DI DMGFAVQ DMGFAVQ DN RG7304 DMGFAVQ MI TTAN5W2 DMGFAVQ MN Raf messenger RNA (Raf mRNA) DMGFAVQ MT DTT DMGFAVQ MA Modulator DMGFAVQ RN Clinical pipeline report, company report or official report of Roche. DMGFAVQ RU http://www.roche.com/research_and_development/who_we_are_how_we_work/pipeline.htm DMIW5NG DI DMIW5NG DMIW5NG DN RG7342 DMIW5NG MI TTHS256 DMIW5NG MN Metabotropic glutamate receptor 5 (mGluR5) DMIW5NG MT DTT DMIW5NG MA Agonist DMIW5NG RN Clinical pipeline report, company report or official report of Roche. DMIW5NG RU http://www.roche.com/irp2q14e-annex.pdf DMOE5NQ DI DMOE5NQ DMOE5NQ DN RG7347 DMOE5NQ MI TTIPJCB DMOE5NQ MN Neuropilin-1 (NRP1) DMOE5NQ MT DTT DMOE5NQ MA Modulator DMOE5NQ RN Neuropilin-1 as Therapeutic Target for Malignant Melanoma. Front Oncol. 2015; 5: 125. DMOE5NQ RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4453476/ DMFDKS7 DI DMFDKS7 DMFDKS7 DN RG-7348 DMFDKS7 MI TTMVBWH DMFDKS7 MN Hepatitis C virus RNA-directed RNA polymerase (HCV NS5B) DMFDKS7 MT DTT DMFDKS7 MA Modulator DMFDKS7 RN Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41. DMFDKS7 RU https://www.ncbi.nlm.nih.gov/pubmed/15950434 DMFGR98 DI DMFGR98 DMFGR98 DN RG-7351 DMFGR98 MI TTIU98M DMFGR98 MN Trace amine-associated receptor-1 (TAAR1) DMFGR98 MT DTT DMFGR98 MA Agonist DMFGR98 RN Clinical pipeline report, company report or official report of Roche. DMFGR98 RU http://www.roche.com/roche_group_pipeline_2010-02-18.pdf DM1NHEA DI DM1NHEA DM1NHEA DN RG7450 DM1NHEA MI TT9E64S DM1NHEA MN Metalloreductase STEAP1 (STEAP1) DM1NHEA MT DTT DM1NHEA MA Modulator DM1NHEA RN Marine-Sourced Anti-Cancer and Cancer Pain Control Agents in Clinical and Late Preclinical Development. Mar Drugs. 2014 January; 12(1): 255-278. DM1NHEA RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3917273/ DM5OTGR DI DM5OTGR DM5OTGR DN RG7461 DM5OTGR MI TTGPQ0F DM5OTGR MN Prolyl endopeptidase FAP (FAP) DM5OTGR MT DTT DM5OTGR MA Antagonist DM5OTGR RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DM5OTGR RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DMK6P9J DI DMK6P9J DMK6P9J DN RG7741 DMK6P9J MI TTTU902 DMK6P9J MN Checkpoint kinase-1 (CHK1) DMK6P9J MT DTT DMK6P9J MA Modulator DMK6P9J RN National Cancer Institute Drug Dictionary (drug id 730054). DMK6P9J RU http://www.cancer.gov/publications/dictionaries/cancer-drug?cdrid=730054 DMXBS6U DI DMXBS6U DMXBS6U DN RG7775 DMXBS6U MI TT08GJW DMXBS6U MN Ubiquitin-protein ligase E3 Mdm2 (MDM2) DMXBS6U MT DTT DMXBS6U MA Inhibitor DMXBS6U RN Phase I clinical trail of RG7775 for treating Acute myelogenous leukemia. Roche. DMXBS6U RU http://www.biocentury.com/products/rg7775 DMACLIH DI DMACLIH DMACLIH DN RG7813 DMACLIH MI TTY6DTE DMACLIH MN Carcinoembryonic antigen CEA (CD66e) DMACLIH MT DTT DMACLIH MA Inhibitor DMACLIH RN Clinical pipeline report, company report or official report of Roche. DMACLIH RU http://www.roche.com/research_and_development/who_we_are_how_we_work/pipeline.htm DMD16JK DI DMD16JK DMD16JK DN RG-7816 DMD16JK MI TTNZPQ1 DMD16JK MN GABA(A) receptor alpha-5 (GABRA5) DMD16JK MT DTT DMD16JK MA Modulator DMD16JK RN Antibodies and venom peptides: new modalities for ion channels. Nat Rev Drug Discov. 2019 May;18(5):339-357. DMD16JK RU https://pubmed.ncbi.nlm.nih.gov/30728472 DMRGHKN DI DMRGHKN DMRGHKN DN RG7827 DMRGHKN MI TTPW9LJ DMRGHKN MN Co-stimulatory molecule 4-1BB (CD137) DMRGHKN MT DTT DMRGHKN MA Agonist DMRGHKN RN Clinical pipeline report, company report or official report of Roche. DMRGHKN RU https://www.roche.com/research_and_development/who_we_are_how_we_work/pipeline.htm DMCUBZO DI DMCUBZO DMCUBZO DN RG7828 DMCUBZO MI TTUE541 DMCUBZO MN Leukocyte surface antigen Leu-16 (CD20) DMCUBZO MT DTT DMCUBZO MA Stimulator DMCUBZO RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMCUBZO RU http://phrma-docs.phrma.org/files/dmfile/MID_Immuno-Oncology-2017_Drug-List1.pdf DMGLXQ9 DI DMGLXQ9 DMGLXQ9 DN RG7854 DMGLXQ9 MI TTRJ1K4 DMGLXQ9 MN Toll-like receptor 7 (TLR7) DMGLXQ9 MT DTT DMGLXQ9 MA Agonist DMGLXQ9 RN Clinical pipeline report, company report or official report of Roche. DMGLXQ9 RU https://www.roche.com/research_and_development/who_we_are_how_we_work/pipeline.htm DM2E5Z7 DI DM2E5Z7 DM2E5Z7 DN RG7882 DM2E5Z7 MI TT4RXME DM2E5Z7 MN Mesothelin (MSLN) DM2E5Z7 MT DTT DM2E5Z7 RN Molecular Imaging As a Tool for Drug Development and Trial Design. JCO July 13, 2015 JCO.2015.61.6425 DM2E5Z7 RU http://jco.ascopubs.org/content/early/2015/07/08/JCO.2015.61.6425.full DM1R4MQ DI DM1R4MQ DM1R4MQ DN RG7893 DM1R4MQ MI TT4G2JS DM1R4MQ MN Voltage-gated sodium channel alpha Nav1.7 (SCN9A) DM1R4MQ MT DTT DM1R4MQ MA Inhibitor DM1R4MQ RN Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800041740) DM1R4MQ RU http://adisinsight.springer.com/drugs/800041740 DMKVIS5 DI DMKVIS5 DMKVIS5 DN RG7907 DMKVIS5 MI TTM42UJ DMKVIS5 MN Hepatitis B virus Capsid protein (HBV C) DMKVIS5 MT DTT DMKVIS5 MA Inhibitor DMKVIS5 RN Clinical pipeline report, company report or official report of Roche. DMKVIS5 RU https://www.roche.com/research_and_development/who_we_are_how_we_work/pipeline.htm DMEGOQP DI DMEGOQP DMEGOQP DN RGB-286638 DMEGOQP MI TTH6V3D DMEGOQP MN Cyclin-dependent kinase 1 (CDK1) DMEGOQP MT DTT DMEGOQP MA Inhibitor DMEGOQP RN Small-molecule multi-targeted kinase inhibitor RGB-286638 triggers P53-dependent and -independent anti-multiple myeloma activity through inhibition of transcriptional CDKs. Leukemia. 2013 Dec;27(12):2366-75. DMEGOQP RU https://pubmed.ncbi.nlm.nih.gov/23807770 DMEGOQP DI DMEGOQP DMEGOQP DN RGB-286638 DMEGOQP MI TT7HF4W DMEGOQP MN Cyclin-dependent kinase 2 (CDK2) DMEGOQP MT DTT DMEGOQP MA Inhibitor DMEGOQP RN Small-molecule multi-targeted kinase inhibitor RGB-286638 triggers P53-dependent and -independent anti-multiple myeloma activity through inhibition of transcriptional CDKs. Leukemia. 2013 Dec;27(12):2366-75. DMEGOQP RU https://pubmed.ncbi.nlm.nih.gov/23807770 DMEGOQP DI DMEGOQP DMEGOQP DN RGB-286638 DMEGOQP MI TTMYWL7 DMEGOQP MN Cyclin-dependent kinase 3 (CDK3) DMEGOQP MT DTT DMEGOQP MA Inhibitor DMEGOQP RN Small-molecule multi-targeted kinase inhibitor RGB-286638 triggers P53-dependent and -independent anti-multiple myeloma activity through inhibition of transcriptional CDKs. Leukemia. 2013 Dec;27(12):2366-75. DMEGOQP RU https://pubmed.ncbi.nlm.nih.gov/23807770 DMEGOQP DI DMEGOQP DMEGOQP DN RGB-286638 DMEGOQP MI TT0PG8F DMEGOQP MN Cyclin-dependent kinase 4 (CDK4) DMEGOQP MT DTT DMEGOQP MA Inhibitor DMEGOQP RN Liposarcoma: molecular genetics and therapeutics. Sarcoma. 2011;2011:483154. DMEGOQP RU https://pubmed.ncbi.nlm.nih.gov/21253554 DMEGOQP DI DMEGOQP DMEGOQP DN RGB-286638 DMEGOQP MI TT1LVF2 DMEGOQP MN Cyclin-dependent kinase 9 (CDK9) DMEGOQP MT DTT DMEGOQP MA Inhibitor DMEGOQP RN Small-molecule multi-targeted kinase inhibitor RGB-286638 triggers P53-dependent and -independent anti-multiple myeloma activity through inhibition of transcriptional CDKs. Leukemia. 2013 Dec;27(12):2366-75. DMEGOQP RU https://pubmed.ncbi.nlm.nih.gov/23807770 DMVJMF1 DI DMVJMF1 DMVJMF1 DN RGD-891 DMVJMF1 MI TT38RM1 DMVJMF1 MN Glycoprotein IIb/IIIa receptor (GPIIb/IIIa) DMVJMF1 MT DTT DMVJMF1 MA Modulator DMVJMF1 RN Pharmacokinetics, pharmacodynamics, and safety of a platelet GPIIb/IIIa antagonist, RGD891, following intravenous administration in healthy male volunteers. J Clin Pharmacol. 2000 Nov;40(11):1245-56. DMVJMF1 RU https://pubmed.ncbi.nlm.nih.gov/11075310 DMQAIU1 DI DMQAIU1 DMQAIU1 DN RGLS4326 DMQAIU1 MI TTMGJ19 DMQAIU1 MN microRNA hsa-miR-17 (MIR17) DMQAIU1 MT DTT DMQAIU1 MA Inhibitor DMQAIU1 RN Discovery and preclinical evaluation of anti-miR-17 oligonucleotide RGLS4326 for the treatment of polycystic kidney disease. Nat Commun. 2019 Sep 12;10(1):4148. DMQAIU1 RU https://pubmed.ncbi.nlm.nih.gov/31515477 DMU87HW DI DMU87HW DMU87HW DN RGX-111 DMU87HW MI TT0IUKX DMU87HW MN Alpha-L-iduronidase (IDUA) DMU87HW MT DTT DMU87HW MA Replacement DMU87HW RN Clinical pipeline report, company report or official report of REGENXBIO. DMU87HW RU https://regenxbio.com/rgx-111/ DM8VGRX DI DM8VGRX DM8VGRX DN RGX-202 DM8VGRX MI TTYUHB5 DM8VGRX MN Solute carrier family 6 member 8 (SLC6A8) DM8VGRX MT DTT DM8VGRX MA Inhibitor DM8VGRX RN Clinical pipeline report, company report or official report of Rgenix. DM8VGRX RU https://rgenix.com/rgx-202/ DMDM85L DI DMDM85L DMDM85L DN RH 1 DMDM85L MI TTUTN1I DMDM85L MN Human Deoxyribonucleic acid (hDNA) DMDM85L MT DTT DMDM85L MA Modulator DMDM85L RN Dissecting the role of multiple reductases in bioactivation and cytotoxicity of the antitumor agent RH1 DMDM85L RU https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2612562 DM1HUA3 DI DM1HUA3 DM1HUA3 DN RHIgM12B7 DM1HUA3 MI TTYOVWN DM1HUA3 MN Programmed cell death protein 2 (PD-2) DM1HUA3 MT DTT DM1HUA3 RN National Cancer Institute Drug Dictionary (drug id 593681). DM1HUA3 RU http://www.cancer.gov/publications/dictionaries/cancer-drug?cdrid=593681 DM2A1DP DI DM2A1DP DM2A1DP DN Ribavirin DM2A1DP MI TT3GRLK DM2A1DP MN HUMAN inosine-5'-monophosphate dehydrogenase 1 (IMPDH1) DM2A1DP MT DTT DM2A1DP MA Inhibitor DM2A1DP RN Proteomics of SARS-CoV-2-infected Host Cells Reveals Therapy Targets. Nature. 2020 May 14. doi: 10.1038/s41586-020-2332-7. DM2A1DP RU https://pubmed.ncbi.nlm.nih.gov/32408336 DM2A1DP DI DM2A1DP DM2A1DP DN Ribavirin DM2A1DP MI TTTU6X1 DM2A1DP MN HUMAN inosine-5'-monophosphate dehydrogenase 2 (IMPDH2) DM2A1DP MT DTT DM2A1DP MA Inhibitor DM2A1DP RN Proteomics of SARS-CoV-2-infected Host Cells Reveals Therapy Targets. Nature. 2020 May 14. doi: 10.1038/s41586-020-2332-7. DM2A1DP RU https://pubmed.ncbi.nlm.nih.gov/32408336 DM2A1DP DI DM2A1DP DM2A1DP DN Ribavirin DM2A1DP MI TTOA6YT DM2A1DP MN MERS-CoV RNA-directed RNA polymerase (RdRp) DM2A1DP MT DTT DM2A1DP MA Inhibitor DM2A1DP RN Coronaviruses - drug discovery and therapeutic options. Nat Rev Drug Discov. 2016 May;15(5):327-47. DM2A1DP RU https://pubmed.ncbi.nlm.nih.gov/26868298 DM2A1DP DI DM2A1DP DM2A1DP DN Ribavirin DM2A1DP MI TTKXI53 DM2A1DP MN SARS-CoV RNA-directed RNA polymerase (RdRp) DM2A1DP MT DTT DM2A1DP MA Inhibitor DM2A1DP RN Coronaviruses - drug discovery and therapeutic options. Nat Rev Drug Discov. 2016 May;15(5):327-47. DM2A1DP RU https://pubmed.ncbi.nlm.nih.gov/26868298 DMB9861 DI DMB9861 DMB9861 DN Rilapladib DMB9861 MI TT9V5JH DMB9861 MN Phospholipase A2 (PLA2G1B) DMB9861 MT DTT DMB9861 MA Modulator DMB9861 RN Effect of treatment for 12 weeks with rilapladib, a lipoprotein-associated phospholipase A2 inhibitor, on arterial inflammation as assessed with 18F-fluorodeoxyglucose-positron emission tomography imaging.J Am Coll Cardiol.2014 Jan 7-14;63(1):86-8. DMB9861 RU https://www.ncbi.nlm.nih.gov/pubmed/23973698 DMB9861 DI DMB9861 DMB9861 DN Rilapladib DMB9861 MI TTDNFMT DMB9861 MN Platelet-activating factor acetylhydrolase (PLA2G7) DMB9861 MT DTT DMB9861 MA Inhibitor DMB9861 RN Phospholipase A2 inhibitors. Curr Opin Lipidol. 2009 Aug;20(4):327-32. DMB9861 RU https://pubmed.ncbi.nlm.nih.gov/19550325 DMB9861 DI DMB9861 DMB9861 DN Rilapladib DMB9861 MI TTP3QRF DMB9861 MN Thymidine kinase 1 (TK1) DMB9861 MT DTT DMB9861 MA Inhibitor DMB9861 RN Trichomonas vaginalis thymidine kinase: purification, characterization and search for inhibitors. Biochem J. 1998 Aug 15;334 ( Pt 1):15-22. DMB9861 RU https://pubmed.ncbi.nlm.nih.gov/9693096 DMUT4YZ DI DMUT4YZ DMUT4YZ DN RLY-1971 DMUT4YZ MI TT7WUAV DMUT4YZ MN Protein-tyrosine phosphatase SHP-2 (PTPN11) DMUT4YZ MT DTT DMUT4YZ MA Inhibitor DMUT4YZ RN Clinical pipeline report, company report or official report of Relay Therapeutics. DMUT4YZ RU https://relaytx.com/pipeline/ DM3O52N DI DM3O52N DM3O52N DN RLY-4008 DM3O52N MI TTGJVQM DM3O52N MN Fibroblast growth factor receptor 2 (FGFR2) DM3O52N MT DTT DM3O52N MA Inhibitor DM3O52N RN Clinical pipeline report, company report or official report of Relay Therapeutics. DM3O52N RU https://relaytx.com/pipeline/ DMQ65YW DI DMQ65YW DMQ65YW DN RO-09-4889 DMQ65YW MI TTZPS91 DMQ65YW MN Dihydrothymine dehydrogenase (DPYD) DMQ65YW MT DTT DMQ65YW MA Modulator DMQ65YW RN Single ascending dose tolerability, pharmacokinetic-pharmacodynamic study of dihydropyrimidine dehydrogenase inhibitor Ro 09-4889. Clin Cancer Res. 2004 Apr 1;10(7):2327-35. DMQ65YW RU https://pubmed.ncbi.nlm.nih.gov/15073108 DM95F8B DI DM95F8B DM95F8B DN RO-14 DM95F8B MI TT4QPUL DM95F8B MN Antithrombin-III (ATIII) DM95F8B MT DTT DM95F8B MA Modulator DM95F8B RN Pharmacological effects and clinical applications of ultra low molecular weight heparins. Drug Discov Ther. 2014 Feb;8(1):1-10. DM95F8B RU https://pubmed.ncbi.nlm.nih.gov/24647152 DM9PQ2N DI DM9PQ2N DM9PQ2N DN RO-23-7553 DM9PQ2N MI TTK59TV DM9PQ2N MN Vitamin D3 receptor (VDR) DM9PQ2N MT DTT DM9PQ2N MA Agonist DM9PQ2N RN Three synthetic vitamin D analogues induce prostate-specific acid phosphatase and prostate-specific antigen while inhibiting the growth of human prostate cancer cells in a vitamin D receptor-dependent fashion. Clin Cancer Res. 1997 Aug;3(8):1331-8. DM9PQ2N RU https://pubmed.ncbi.nlm.nih.gov/9815816 DML4C3Q DI DML4C3Q DML4C3Q DN RO-5212054 DML4C3Q MI TTWCGQT DML4C3Q MN Serine/threonine-protein kinase B-raf (BRAF) DML4C3Q MT DTT DML4C3Q MA Inhibitor DML4C3Q RN National Cancer Institute Drug Dictionary (drug id 680347). DML4C3Q RU http://www.cancer.gov/publications/dictionaries/cancer-drug?cdrid=680347 DMVXQ5W DI DMVXQ5W DMVXQ5W DN RO-5458640 DMVXQ5W MI TTBTDM1 DMVXQ5W MN TNF-related weak inducer of apoptosis (TWEAK) DMVXQ5W MT DTT DMVXQ5W MA Modulator DMVXQ5W RN A novel llama antibody targeting Fn14 exhibits anti-metastatic activity in vivo. MAbs. 2014 January 1; 6(1): 297-308. DMVXQ5W RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3929451/ DM7H6XI DI DM7H6XI DM7H6XI DN RO6870810 DM7H6XI MI TTE4BSY DM7H6XI MN Bromodomain and extraterminal domain protein (BET) DM7H6XI MT DTT DM7H6XI MA Inhibitor DM7H6XI RN A Phase 1 study of RO6870810, a novel bromodomain and extra-terminal protein inhibitor, in patients with NUT carcinoma, other solid tumours, or diffuse large B-cell lymphoma. Br J Cancer. 2021 Feb;124(4):744-753. DM7H6XI RU https://pubmed.ncbi.nlm.nih.gov/33311588 DMDRBNJ DI DMDRBNJ DMDRBNJ DN ROCICLOVIR DMDRBNJ MI TTIU7X1 DMDRBNJ MN Herpes simplex virus DNA polymerase UL30 (HSV UL30) DMDRBNJ MT DTT DMDRBNJ MA Modulator DMDRBNJ RN Herpes simplex virus type 1 DNA polymerase. Mechanism of inhibition by acyclovir triphosphate. J Biol Chem. 1989 May 5;264(13):7405-11. DMDRBNJ RU https://pubmed.ncbi.nlm.nih.gov/2540193 DM82KWY DI DM82KWY DM82KWY DN Ronomilast DM82KWY MI TTZ97H5 DM82KWY MN Phosphodiesterase 4A (PDE4A) DM82KWY MT DTT DM82KWY MA Inhibitor DM82KWY RN Clinical pipeline report, company report or official report of Avarx. DM82KWY RU http://www.avarx.com/AvaRx/SubDomains/bucket3609200049721832467/Listings/bucket3113046654580504235/Public.Listing.display.html DM82KWY DI DM82KWY DM82KWY DN Ronomilast DM82KWY MI TTVIAT9 DM82KWY MN Phosphodiesterase 4B (PDE4B) DM82KWY MT DTT DM82KWY MA Inhibitor DM82KWY RN Clinical pipeline report, company report or official report of Avarx. DM82KWY RU http://www.avarx.com/AvaRx/SubDomains/bucket3609200049721832467/Listings/bucket3113046654580504235/Public.Listing.display.html DM82KWY DI DM82KWY DM82KWY DN Ronomilast DM82KWY MI TTSKMI8 DM82KWY MN Phosphodiesterase 4D (PDE4D) DM82KWY MT DTT DM82KWY MA Inhibitor DM82KWY RN Clinical pipeline report, company report or official report of Avarx. DM82KWY RU http://www.avarx.com/AvaRx/SubDomains/bucket3609200049721832467/Listings/bucket3113046654580504235/Public.Listing.display.html DM5EUIY DI DM5EUIY DM5EUIY DN ROR1 CAR-specific Autologous T-Lymphocytes DM5EUIY MI TTDEJAU DM5EUIY MN Neurotrophic tyrosine kinase ROR1 (ROR1) DM5EUIY MT DTT DM5EUIY MA CAR-T-Cell-Therapy DM5EUIY RN ClinicalTrials.gov (NCT02706392) Genetically Modified T-Cell Therapy in Treating Patients With Advanced ROR1+ Malignancies DM5EUIY RU https://clinicaltrials.gov/ct2/show/NCT02706392 DMIAK9P DI DMIAK9P DMIAK9P DN ROR1R-CAR-T Cell DMIAK9P MI TTDEJAU DMIAK9P MN Neurotrophic tyrosine kinase ROR1 (ROR1) DMIAK9P MT DTT DMIAK9P MA CAR-T-Cell-Therapy DMIAK9P RN ClinicalTrials.gov (NCT02194374) Autologous ROR1R-CAR-T Cells for Chronic Lymphocytic Leukemia (CLL) DMIAK9P RU https://clinicaltrials.gov/ct2/show/NCT02194374 DM9O3RY DI DM9O3RY DM9O3RY DN Rosmantuzumab DM9O3RY MI TT7HJTF DM9O3RY MN R-spondin-3 (RSPO3) DM9O3RY MT DTT DM9O3RY MA Inhibitor DM9O3RY RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DM9O3RY RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DME9UTO DI DME9UTO DME9UTO DN RP4010 DME9UTO MI TTE76YK DME9UTO MN Calcium-release activated calcium channel (CRACM) DME9UTO MT DTT DME9UTO MA Inhibitor DME9UTO RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DME9UTO RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DMHZ24N DI DMHZ24N DMHZ24N DN RP-A501 DMHZ24N MI TTULDG7 DMHZ24N MN Lysosome-associated membrane glycoprotein 2 (LAMP2) DMHZ24N MT DTT DMHZ24N MA Replacement DMHZ24N RN ClinicalTrials.gov (NCT03882437) Gene Therapy for Male Patients With Danon Disease (DD) Using RP-A501; AAV9.LAMP2B. U.S. National Institutes of Health. DMHZ24N RU https://clinicaltrials.gov/ct2/show/NCT03882437 DMXKFOQ DI DMXKFOQ DMXKFOQ DN RPI-78M DMXKFOQ MI TTJSZTB DMXKFOQ MN Nicotinic acetylcholine receptor (nAChR) DMXKFOQ MT DTT DMXKFOQ MA Antagonist DMXKFOQ RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMXKFOQ RU http://phrma-docs.phrma.org/files/dmfile/medicines-in-development-drug-list-autoimmune-diseases.pdf DM5OXPZ DI DM5OXPZ DM5OXPZ DN RPI-MN DM5OXPZ MI TTJSZTB DM5OXPZ MN Nicotinic acetylcholine receptor (nAChR) DM5OXPZ MT DTT DM5OXPZ MA Antagonist DM5OXPZ RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DM5OXPZ RU http://phrma-docs.phrma.org/files/dmfile/MID_Neurological-Disorders-Drug-List_2018.pdf DMA6JME DI DMA6JME DMA6JME DN RTA 901 DMA6JME MI TTO7FVG DMA6JME MN Heat shock protein 90 (HSP90) DMA6JME MT DTT DMA6JME MA Inhibitor DMA6JME RN Clinical pipeline report, company report or official report of Reata Pharmaceuticals. DMA6JME RU https://www.reatapharma.com/our-science/default.aspx DM7C062 DI DM7C062 DM7C062 DN RTA-901 DM7C062 MI TT78R5H DM7C062 MN Heat shock protein 90 alpha (HSP90A) DM7C062 MT DTT DM7C062 MA Modulator DM7C062 RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DM7C062 RU http://phrma-docs.phrma.org/files/dmfile/MID_Neurological-Disorders-Drug-List_2018.pdf DMY8D5O DI DMY8D5O DMY8D5O DN RTI-336 DMY8D5O MI TTVBI8W DMY8D5O MN Dopamine transporter (DAT) DMY8D5O MT DTT DMY8D5O MA Modulator DMY8D5O RN Development of the dopamine transporter selective RTI-336 as a pharmacotherapy for cocaine abuse.AAPS J.2006 Mar 24;8(1):E196-203. DMY8D5O RU https://www.ncbi.nlm.nih.gov/pubmed/16584128 DM1B4CQ DI DM1B4CQ DM1B4CQ DN RTL-1000 DM1B4CQ MI TTXQYT6 DM1B4CQ MN T-cells (T-cells) DM1B4CQ MT DTT DM1B4CQ MA Binder DM1B4CQ RN RTL THERAPY FOR MULTIPLE SCLEROSIS: A Phase I Clinical Study. J Neuroimmunol. 2011 February; 231(1-2): 7-14. DM1B4CQ RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3026883/ DMYRPC8 DI DMYRPC8 DMYRPC8 DN RVSVIN HIV-1 gag vaccine DMYRPC8 MI TTFGZB6 DMYRPC8 MN Human immunodeficiency virus GAG protein (HIV gag) DMYRPC8 MT DTT DMYRPC8 RN Recombinant vesicular stomatitis virus-based vaccines against Ebola and Marburg virus infections. J Infect Dis. 2011 Nov;204 Suppl 3:S1075-81. DMYRPC8 RU https://pubmed.ncbi.nlm.nih.gov/21987744 DM0YCG3 DI DM0YCG3 DM0YCG3 DN RVT-103+RVT-104 DM0YCG3 MI TTEB0GD DM0YCG3 MN Cholinesterase (BCHE) DM0YCG3 MT DTT DM0YCG3 MA Inhibitor DM0YCG3 RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DM0YCG3 RU http://phrma-docs.phrma.org/files/dmfile/MID-Update_Alzheimers-Disease_2017-Drug-List.pdf DMJVCS1 DI DMJVCS1 DMJVCS1 DN RWJ-671818 DMJVCS1 MI TT6L509 DMJVCS1 MN Coagulation factor IIa (F2) DMJVCS1 MT DTT DMJVCS1 MA Modulator DMJVCS1 RN Discovery and clinical evaluation of 1-{N-[2-(amidinoaminooxy)ethyl]amino}carbonylmethyl-6-methyl-3-[2,2-difluoro-2-phenylethylamino]pyrazinone (RW... J Med Chem. 2010 Feb 25;53(4):1843-56. DMJVCS1 RU https://pubmed.ncbi.nlm.nih.gov/20102150 DM6YAGE DI DM6YAGE DM6YAGE DN RWJ-67657 DM6YAGE MI TTVKILB DM6YAGE MN Prostaglandin G/H synthase 2 (COX-2) DM6YAGE MT DTT DM6YAGE MA Inhibitor DM6YAGE RN Monocyte intracellular cytokine production during human endotoxaemia with or without a second in vitro LPS challenge: effect of RWJ-67657, a p38 MAP-kinase inhibitor, on LPS-hyporesponsiveness. Clin Exp Immunol. 2002 Feb;127(2):337-43. DM6YAGE RU https://pubmed.ncbi.nlm.nih.gov/11876759 DM4O07Q DI DM4O07Q DM4O07Q DN RWJ-68023 DM4O07Q MI TT953CX DM4O07Q MN Motilin receptor (MLNR) DM4O07Q MT DTT DM4O07Q MA Antagonist DM4O07Q RN Effects of a nonpeptide motilin receptor antagonist on proximal gastric motor function. Br J Clin Pharmacol. 2004 Apr;57(4):393-401. DM4O07Q RU https://pubmed.ncbi.nlm.nih.gov/15025736 DM4XETK DI DM4XETK DM4XETK DN RX108 DM4XETK MI TTQ38E9 DM4XETK MN Sodium/potassium-transporting ATPase (SPT ATPase) DM4XETK MT DTT DM4XETK MA Inhibitor DM4XETK RN ClinicalTrials.gov (NCT03646071) A Study of RX108 in Patients With Locally Advanced or Metastatic Solid Tumors. U.S. National Institutes of Health. DM4XETK RU https://clinicaltrials.gov/ct2/show/NCT03646071 DM6NVTR DI DM6NVTR DM6NVTR DN RXDX-106 DM6NVTR MI TTNDSF4 DM6NVTR MN Proto-oncogene c-Met (MET) DM6NVTR MT DTT DM6NVTR MA Inhibitor DM6NVTR RN National Cancer Institute Drug Dictionary (drug name RXDX106). DM6NVTR RU https://www.cancer.gov/publications/dictionaries/cancer-drug/def/tam-c-met-inhibitor-rxdx-106 DM6NVTR DI DM6NVTR DM6NVTR DN RXDX-106 DM6NVTR MI TTIEMFN DM6NVTR MN TYRO3 tyrosine kinase receptor (TYRO3) DM6NVTR MT DTT DM6NVTR MA Inhibitor DM6NVTR RN National Cancer Institute Drug Dictionary (drug name RXDX106). DM6NVTR RU https://www.cancer.gov/publications/dictionaries/cancer-drug/def/tam-c-met-inhibitor-rxdx-106 DM6NVTR DI DM6NVTR DM6NVTR DN RXDX-106 DM6NVTR MI TTO7LKR DM6NVTR MN Tyrosine-protein kinase Mer (MERTK) DM6NVTR MT DTT DM6NVTR MA Inhibitor DM6NVTR RN National Cancer Institute Drug Dictionary (drug name RXDX106). DM6NVTR RU https://www.cancer.gov/publications/dictionaries/cancer-drug/def/tam-c-met-inhibitor-rxdx-106 DM6NVTR DI DM6NVTR DM6NVTR DN RXDX-106 DM6NVTR MI TTZPY6J DM6NVTR MN Tyrosine-protein kinase UFO (AXL) DM6NVTR MT DTT DM6NVTR MA Inhibitor DM6NVTR RN National Cancer Institute Drug Dictionary (drug name RXDX106). DM6NVTR RU https://www.cancer.gov/publications/dictionaries/cancer-drug/def/tam-c-met-inhibitor-rxdx-106 DMYR1K8 DI DMYR1K8 DMYR1K8 DN S-17092-1 DMYR1K8 MI TTNGKET DMYR1K8 MN Prolyl endopeptidase (PREP) DMYR1K8 MT DTT DMYR1K8 MA Inhibitor DMYR1K8 RN Effect of S 17092, a novel prolyl endopeptidase inhibitor, on substance P and alpha-melanocyte-stimulating hormone breakdown in the rat brain. J Neurochem. 2003 Mar;84(5):919-29. DMYR1K8 RU https://pubmed.ncbi.nlm.nih.gov/12603817 DMDQRWT DI DMDQRWT DMDQRWT DN S-265744 LAP DMDQRWT MI TT5FH9Y DMDQRWT MN Human immunodeficiency virus Integrase (HIV IN) DMDQRWT MT DTT DMDQRWT MA Inhibitor DMDQRWT RN Long-acting shot prevents infection with HIV analogue. Nature. doi:10.1038/nature.2014.14819. 04 March 2014 DMDQRWT RU http://www.nature.com/news/long-acting-shot-prevents-infection-with-hiv-analogue-1.14819 DM6XZRL DI DM6XZRL DM6XZRL DN SA-5845 DM6XZRL MI TT5TPI6 DM6XZRL MN Opioid receptor sigma 1 (OPRS1) DM6XZRL MT DTT DM6XZRL MA Binder DM6XZRL RN Tumor imaging with 2 sigma-receptor ligands, 18F-FE-SA5845 and 11C-SA4503: a feasibility study. J Nucl Med. 2004 Nov;45(11):1939-45. DM6XZRL RU https://pubmed.ncbi.nlm.nih.gov/15534066 DMBGUDR DI DMBGUDR DMBGUDR DN Safingol DMBGUDR MI DE4LYSA DMBGUDR MN Cytochrome P450 3A4 (CYP3A4) DMBGUDR MT DME DMBGUDR MA Metabolism DMBGUDR RN Sex differences in rat hepatic cytolethality of the protein kinase C inhibitor safingol: role of biotransformation. Toxicol Appl Pharmacol. 1996 Apr;137(2):173-81. DMBGUDR RU https://www.ncbi.nlm.nih.gov/pubmed/?term=8661342 DMBGUDR DI DMBGUDR DMBGUDR DN Safingol DMBGUDR MI TTYVX59 DMBGUDR MN Protein kinase C (PRKC) DMBGUDR MT DTT DMBGUDR MA Inhibitor DMBGUDR RN The role of protein kinase C in the synergistic interaction of safingol and irinotecan in colon cancer cells. Int J Oncol. 2009 Dec;35(6):1463-71. DMBGUDR RU https://pubmed.ncbi.nlm.nih.gov/19885570 DM1UIQP DI DM1UIQP DM1UIQP DN SAFIRONIL DM1UIQP MI TTNH25W DM1UIQP MN Prolyl 4-hydroxylasesubunit alpha-1 (P4HA1) DM1UIQP MT DTT DM1UIQP MA Modulator DM1UIQP RN Antifibrogenic therapies in chronic HCV infection. Curr Drug Targets Infect Disord. 2001 Aug;1(2):227-40. DM1UIQP RU https://pubmed.ncbi.nlm.nih.gov/12455417 DMJ3HQY DI DMJ3HQY DMJ3HQY DN Salvinorin A DMJ3HQY MI DE6OQ3W DMJ3HQY MN Cytochrome P450 1A1 (CYP1A1) DMJ3HQY MT DME DMJ3HQY MA Metabolism DMJ3HQY RN Evaluation of the transport, in vitro metabolism and pharmacokinetics of Salvinorin A, a potent hallucinogen. Eur J Pharm Biopharm. 2009 Jun;72(2):471-7. DMJ3HQY RU https://www.ncbi.nlm.nih.gov/pubmed/?term=19462483 DMJ3HQY DI DMJ3HQY DMJ3HQY DN Salvinorin A DMJ3HQY MI DEZMWRE DMJ3HQY MN Cytochrome P450 2C18 (CYP2C18) DMJ3HQY MT DME DMJ3HQY MA Metabolism DMJ3HQY RN Evaluation of the transport, in vitro metabolism and pharmacokinetics of Salvinorin A, a potent hallucinogen. Eur J Pharm Biopharm. 2009 Jun;72(2):471-7. DMJ3HQY RU https://www.ncbi.nlm.nih.gov/pubmed/?term=19462483 DMJ3HQY DI DMJ3HQY DMJ3HQY DN Salvinorin A DMJ3HQY MI DECB0K3 DMJ3HQY MN Cytochrome P450 2D6 (CYP2D6) DMJ3HQY MT DME DMJ3HQY MA Metabolism DMJ3HQY RN Evaluation of the transport, in vitro metabolism and pharmacokinetics of Salvinorin A, a potent hallucinogen. Eur J Pharm Biopharm. 2009 Jun;72(2):471-7. DMJ3HQY RU https://www.ncbi.nlm.nih.gov/pubmed/?term=19462483 DMJ3HQY DI DMJ3HQY DMJ3HQY DN Salvinorin A DMJ3HQY MI DEVDYN7 DMJ3HQY MN Cytochrome P450 2E1 (CYP2E1) DMJ3HQY MT DME DMJ3HQY MA Metabolism DMJ3HQY RN Evaluation of the transport, in vitro metabolism and pharmacokinetics of Salvinorin A, a potent hallucinogen. Eur J Pharm Biopharm. 2009 Jun;72(2):471-7. DMJ3HQY RU https://www.ncbi.nlm.nih.gov/pubmed/?term=19462483 DMJ3HQY DI DMJ3HQY DMJ3HQY DN Salvinorin A DMJ3HQY MI TT27RFC DMJ3HQY MN Opioid receptor delta (OPRD1) DMJ3HQY MT DTT DMJ3HQY MA Inhibitor DMJ3HQY RN Herkinorin analogues with differential beta-arrestin-2 interactions. J Med Chem. 2008 Apr 24;51(8):2421-31. DMJ3HQY RU https://pubmed.ncbi.nlm.nih.gov/18380425 DMJ3HQY DI DMJ3HQY DMJ3HQY DN Salvinorin A DMJ3HQY MI TTQW87Y DMJ3HQY MN Opioid receptor kappa (OPRK1) DMJ3HQY MT DTT DMJ3HQY MA Inhibitor DMJ3HQY RN Toward a structure-based model of salvinorin A recognition of the kappa-opioid receptor. J Med Chem. 2008 Mar 27;51(6):1824-30. DMJ3HQY RU https://pubmed.ncbi.nlm.nih.gov/18293909 DMJ3HQY DI DMJ3HQY DMJ3HQY DN Salvinorin A DMJ3HQY MI TTKWM86 DMJ3HQY MN Opioid receptor mu (MOP) DMJ3HQY MT DTT DMJ3HQY MA Inhibitor DMJ3HQY RN Herkinorin analogues with differential beta-arrestin-2 interactions. J Med Chem. 2008 Apr 24;51(8):2421-31. DMJ3HQY RU https://pubmed.ncbi.nlm.nih.gov/18380425 DMJ3HQY DI DMJ3HQY DMJ3HQY DN Salvinorin A DMJ3HQY MI DEB3CV1 DMJ3HQY MN UDP-glucuronosyltransferase 2B7 (UGT2B7) DMJ3HQY MT DME DMJ3HQY MA Metabolism DMJ3HQY RN Evaluation of the transport, in vitro metabolism and pharmacokinetics of Salvinorin A, a potent hallucinogen. Eur J Pharm Biopharm. 2009 Jun;72(2):471-7. DMJ3HQY RU https://www.ncbi.nlm.nih.gov/pubmed/?term=19462483 DMDHQYA DI DMDHQYA DMDHQYA DN SAM-6 DMDHQYA MI TTW26OG DMDHQYA MN Endoplasmic reticulum chaperone BiP (HSPA5) DMDHQYA MT DTT DMDHQYA RN A new tumor-specific variant of GRP78 as target for antibody-based therapy. Lab Invest. 2008 Apr;88(4):375-86. DMDHQYA RU https://pubmed.ncbi.nlm.nih.gov/18268478 DMWU71N DI DMWU71N DMWU71N DN SAN-134 DMWU71N MI TT1YWO5 DMWU71N MN Glucagon-like peptide 2 receptor (GLP2R) DMWU71N MT DTT DMWU71N MA Inhibitor DMWU71N RN Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800020865) DMWU71N RU http://adisinsight.springer.com/drugs/800020865 DMQ9ZY0 DI DMQ9ZY0 DMQ9ZY0 DN SAR-104772 DMQ9ZY0 MI TTP18AY DMQ9ZY0 MN Carboxypeptidase B2 (CPB2) DMQ9ZY0 MT DTT DMQ9ZY0 MA Inhibitor DMQ9ZY0 RN Carboxypeptidase U (TAFIa): a new drug target for fibrinolytic therapy . Journal of Thrombosis and Haemostasis Volume 7, Issue 12, pages 1962-1971, December 2009. DMQ9ZY0 RU http://onlinelibrary.wiley.com/doi/10.1111/j.1538-7836.2009.03596.x/full DMRIH0S DI DMRIH0S DMRIH0S DN SAR113244 DMRIH0S MI TTIW59R DMRIH0S MN C-X-C chemokine receptor type 5 (CXCR5) DMRIH0S MT DTT DMRIH0S MA Modulator DMRIH0S RN Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41. DMRIH0S RU https://www.ncbi.nlm.nih.gov/pubmed/15950434 DMZ1XR5 DI DMZ1XR5 DMZ1XR5 DN SAR-114137 DMZ1XR5 MI TTDZN01 DMZ1XR5 MN Cathepsin K (CTSK) DMZ1XR5 MT DTT DMZ1XR5 MA Inhibitor DMZ1XR5 RN From laboratory to pilot plant: the solid-state process development of a highly potent cathepsin S/K inhibitor. Eur J Pharm Biopharm. 2013 Apr;83(3):436-48. DMZ1XR5 RU https://pubmed.ncbi.nlm.nih.gov/23201054 DMZ1XR5 DI DMZ1XR5 DMZ1XR5 DN SAR-114137 DMZ1XR5 MI TTUMQVO DMZ1XR5 MN Cathepsin S (CTSS) DMZ1XR5 MT DTT DMZ1XR5 MA Inhibitor DMZ1XR5 RN From laboratory to pilot plant: the solid-state process development of a highly potent cathepsin S/K inhibitor. Eur J Pharm Biopharm. 2013 Apr;83(3):436-48. DMZ1XR5 RU https://pubmed.ncbi.nlm.nih.gov/23201054 DMD2VRY DI DMD2VRY DMD2VRY DN SAR-115740 DMD2VRY MI TTMI6F5 DMD2VRY MN Transient receptor potential cation channel V1 (TRPV1) DMD2VRY MT DTT DMD2VRY MA Antagonist DMD2VRY RN Clinical pipeline report, company report or official report of Sanofi. DMD2VRY RU https://ncats.nih.gov/files/SAR115740.pdf DMKHM7O DI DMKHM7O DMKHM7O DN SAR-126119 DMKHM7O MI TTP18AY DMKHM7O MN Carboxypeptidase B2 (CPB2) DMKHM7O MT DTT DMKHM7O MA Inhibitor DMKHM7O RN TAFIa inhibitors in the treatment of thrombosis. Curr Opin Drug Discov Devel. 2008 Jul;11(4):480-6. DMKHM7O RU https://pubmed.ncbi.nlm.nih.gov/18600565 DMQ98MW DI DMQ98MW DMQ98MW DN SAR164653 DMQ98MW MI TT5NILS DMQ98MW MN Cathepsin A (CTSA) DMQ98MW MT DTT DMQ98MW MA Modulator DMQ98MW RN Tolerability, safety and pharmacokinetics of the novel Cathepsin A inhibitor SAR164653 in healthy subjects.Clinical Pharmacology in Drug Development 05/2015. DMQ98MW RU http://www.researchgate.net/publication/276150796_Tolerability_safety_and_pharmacokinetics_of_the_novel_Cathepsin_A_inhibitor_SAR164653_in_healthy_subjects DMO8QY1 DI DMO8QY1 DMO8QY1 DN SAR-21609 DMO8QY1 MI TTSHG0T DMO8QY1 MN Toll-like receptor 9 (TLR9) DMO8QY1 MT DTT DMO8QY1 MA Agonist DMO8QY1 RN Trial Watch: Experimental Toll-like receptor agonists for cancer therapy. Oncoimmunology. 2012 August 1; 1(5): 699-716. DMO8QY1 RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3429574/ DMTFAGU DI DMTFAGU DMTFAGU DN SAR228810 DMTFAGU MI TTE4KHA DMTFAGU MN Amyloid beta A4 protein (APP) DMTFAGU MT DTT DMTFAGU RN SAR228810: An antiprotofibrillar beta-amyloid antibody designed to reduce risk of amyloid-related imaging abnormalities (ARIA). Alzheimer's & Dementia Volume 9, Issue 4, Supplement, July 2013, Pages P808-P809. DMTFAGU RU http://www.sciencedirect.com/science/article/pii/S1552526013023352 DMUAJZD DI DMUAJZD DMUAJZD DN SAR247799 DMUAJZD MI TT9JZCK DMUAJZD MN Sphingosine-1-phosphate receptor 1 (S1PR1) DMUAJZD MT DTT DMUAJZD MA Agonist DMUAJZD RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMUAJZD RU http://phrma-docs.phrma.org/files/dmfile/2018_Heart-Disease-and-Stroke_MID-Drug-List.pdf DM15PG9 DI DM15PG9 DM15PG9 DN SAR351034 DM15PG9 MI TT2JWF6 DM15PG9 MN Peroxisome proliferator-activated receptor delta (PPARD) DM15PG9 MT DTT DM15PG9 MA Modulator DM15PG9 RN Addressing Unmet Medical Needs in Type 2 Diabetes: A Narrative Review of Drugs under Development. Curr Diabetes Rev. 2015 March; 11(1): 17-31. DM15PG9 RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4428473/ DMA6O9R DI DMA6O9R DMA6O9R DN SAR-389644 DMA6O9R MI TTNVEIR DMA6O9R MN Prostaglandin D2 receptor (PTGDR) DMA6O9R MT DTT DMA6O9R MA Antagonist DMA6O9R RN US patent application no. 2008,0300,217, Combination therapy with fumaric acid esters for the treatment of autoimmune and,or inflammatory disorders. DMA6O9R RU http://www.google.com/patents/US20080300217 DMC1AZP DI DMC1AZP DMC1AZP DN SAR-405838 DMC1AZP MI TT7SBF5 DMC1AZP MN Cellular tumor antigen p53 (TP53) DMC1AZP MT DTT DMC1AZP MA Modulator DMC1AZP RN SAR405838: an optimized inhibitor of MDM2-p53 interaction that induces complete and durable tumor regression. Cancer Res. 2014 Oct 15;74(20):5855-65. DMC1AZP RU https://pubmed.ncbi.nlm.nih.gov/25145672 DM53IPE DI DM53IPE DM53IPE DN SAR425899 DM53IPE MI TT0NUFM DM53IPE MN Glucagon (GCG) DM53IPE MT DTT DM53IPE MA Agonist DM53IPE RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DM53IPE RU http://phrma-docs.phrma.org/files/dmfile/mid-diabetes-drug-list.pdf DM53IPE DI DM53IPE DM53IPE DN SAR425899 DM53IPE MI TT9O6WS DM53IPE MN Glucagon receptor (GCGR) DM53IPE MT DTT DM53IPE MA Modulator DM53IPE RN Company report (Sanofi) (drug: LIXisenatide) DM53IPE RU http://www.sanofi.com/Images/38980_IR_Call_ADA2015_FINAL.pdf DM53IPE DI DM53IPE DM53IPE DN SAR425899 DM53IPE MI TTVIMDE DM53IPE MN Glucagon-like peptide 1 receptor (GLP1R) DM53IPE MT DTT DM53IPE MA Modulator DM53IPE RN Company report (Sanofi) (drug: LIXisenatide) DM53IPE RU http://www.sanofi.com/Images/38980_IR_Call_ADA2015_FINAL.pdf DM7QO05 DI DM7QO05 DM7QO05 DN SAR438335 DM7QO05 MI TTYMKBE DM7QO05 MN Gastric inhibitory polypeptide receptor (GIPR) DM7QO05 MT DTT DM7QO05 MA Agonist DM7QO05 RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DM7QO05 RU http://phrma-docs.phrma.org/files/dmfile/mid-diabetes-drug-list.pdf DM7QO05 DI DM7QO05 DM7QO05 DN SAR438335 DM7QO05 MI TTVIMDE DM7QO05 MN Glucagon-like peptide 1 receptor (GLP1R) DM7QO05 MT DTT DM7QO05 MA Agonist DM7QO05 RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DM7QO05 RU http://phrma-docs.phrma.org/files/dmfile/mid-diabetes-drug-list.pdf DM5UXAB DI DM5UXAB DM5UXAB DN SAR442085 DM5UXAB MI TTPURFN DM5UXAB MN Cyclic ADP-ribose hydrolase 1 (CD38) DM5UXAB MT DTT DM5UXAB MA Inhibitor DM5UXAB RN Clinical pipeline report, company report or official report of Sanofi. DM5UXAB RU https://www.sanofi.com/en/science-and-innovation/research-and-development/rd-pipeline DMXD5QP DI DMXD5QP DMXD5QP DN SAR442257 DMXD5QP MI TTPURFN DMXD5QP MN Cyclic ADP-ribose hydrolase 1 (CD38) DMXD5QP MT DTT DMXD5QP MA Inhibitor DMXD5QP RN Clinical pipeline report, company report or official report of Sanofi. DMXD5QP RU https://www.sanofi.com/en/science-and-innovation/research-and-development/rd-pipeline DMXD5QP DI DMXD5QP DMXD5QP DN SAR442257 DMXD5QP MI TTUN7MC DMXD5QP MN T-cell surface glycoprotein CD3 (CD3) DMXD5QP MT DTT DMXD5QP MA Inhibitor DMXD5QP RN Clinical pipeline report, company report or official report of Sanofi. DMXD5QP RU https://www.sanofi.com/en/science-and-innovation/research-and-development/rd-pipeline DMXD5QP DI DMXD5QP DMXD5QP DN SAR442257 DMXD5QP MI TTQ13FT DMXD5QP MN T-cell-specific surface glycoprotein CD28 (CD28) DMXD5QP MT DTT DMXD5QP MA Inhibitor DMXD5QP RN Clinical pipeline report, company report or official report of Sanofi. DMXD5QP RU https://www.sanofi.com/en/science-and-innovation/research-and-development/rd-pipeline DMTAOPC DI DMTAOPC DMTAOPC DN SAR442720 DMTAOPC MI TT7WUAV DMTAOPC MN Protein-tyrosine phosphatase SHP-2 (PTPN11) DMTAOPC MT DTT DMTAOPC MA Inhibitor DMTAOPC RN Clinical pipeline report, company report or official report of Revolution Medicines. DMTAOPC RU https://www.revmed.com/pipeline/rmc-4630 DM6UN42 DI DM6UN42 DM6UN42 DN SAR444245 DM6UN42 MI TTF89GD DM6UN42 MN Interleukin-2 (IL2) DM6UN42 MT DTT DM6UN42 RN Clinical pipeline report, company report or official report of Sanofi. DM6UN42 RU https://www.sanofi.com/en/media-room/press-releases/2020/2020-10-29-07-00-00 DMZ9YWG DI DMZ9YWG DMZ9YWG DN SB 11285 DMZ9YWG MI TTT402Y DMZ9YWG MN Stimulator of interferon genes protein (TMEM173) DMZ9YWG MT DTT DMZ9YWG MA Agonist DMZ9YWG RN Clinical pipeline report, company report or official report of F-star Therapeutics. DMZ9YWG RU https://www.f-star.com/pipeline/sb-11285/ DMXTKYR DI DMXTKYR DMXTKYR DN SB-1578 DMXTKYR MI TTRMX3V DMXTKYR MN Janus kinase 2 (JAK-2) DMXTKYR MT DTT DMXTKYR MA Inhibitor DMXTKYR RN Selective JAK inhibitors in development for rheumatoid arthritis. Expert Opin Investig Drugs. 2014 Aug;23(8):1067-77. DMXTKYR RU https://pubmed.ncbi.nlm.nih.gov/24818516 DMLPB0X DI DMLPB0X DMLPB0X DN SB-436811 DMLPB0X MI TTW5UDX DMLPB0X MN Urotensin II receptor (UTS2R) DMLPB0X MT DTT DMLPB0X MA Inhibitor DMLPB0X RN Urotensin-II receptor modulators as potential drugs. J Med Chem. 2010 Apr 8;53(7):2695-708. DMLPB0X RU https://pubmed.ncbi.nlm.nih.gov/20043680 DMSZIP5 DI DMSZIP5 DMSZIP5 DN SB-639 DMSZIP5 MI TT6R7JZ DMSZIP5 MN Histone deacetylase 1 (HDAC1) DMSZIP5 MT DTT DMSZIP5 MA Inhibitor DMSZIP5 RN Histone deacetylase inhibitors in cancer therapy: latest developments, trends and medicinal chemistry perspective. Anticancer Agents Med Chem. 2007 Sep;7(5):576-92. DMSZIP5 RU https://pubmed.ncbi.nlm.nih.gov/17896917 DMXU2GS DI DMXU2GS DMXU2GS DN SBS-1000 DMXU2GS MI TTZOPHG DMXU2GS MN Insulin (INS) DMXU2GS MT DTT DMXU2GS MA Modulator DMXU2GS RN Synergistic antihyperglycemic effects between plant-derived oleanolic acid and insulin in streptozotocin-induced diabetic rats. Ren Fail. 2010;32(7):832-9. DMXU2GS RU https://pubmed.ncbi.nlm.nih.gov/20662697 DMHBD3T DI DMHBD3T DMHBD3T DN SBT6050 DMHBD3T MI TT6EO5L DMHBD3T MN Erbb2 tyrosine kinase receptor (HER2) DMHBD3T MT DTT DMHBD3T RN Clinical pipeline report, company report or official report of Silverback Therapeutics. DMHBD3T RU https://silverbacktx.com/pipeline/#sbt6050 DMHBD3T DI DMHBD3T DMHBD3T DN SBT6050 DMHBD3T MI TT8CWFK DMHBD3T MN Toll-like receptor 8 (TLR8) DMHBD3T MT DTT DMHBD3T MA Agonist DMHBD3T RN Clinical pipeline report, company report or official report of Silverback Therapeutics. DMHBD3T RU https://silverbacktx.com/pipeline/#sbt6050 DM7GSLB DI DM7GSLB DM7GSLB DN SC-20713 DM7GSLB MI DE4LYSA DM7GSLB MN Cytochrome P450 3A4 (CYP3A4) DM7GSLB MT DME DM7GSLB MA Metabolism DM7GSLB RN News and information in drug research: Ethynodiol diacetate. DM7GSLB RU http://genelabs.com/drugsdb/details/ethynodiol-diacetate/ DMQ2K1V DI DMQ2K1V DMQ2K1V DN SCH-442416 DMQ2K1V MI TTK25J1 DMQ2K1V MN Adenosine A1 receptor (ADORA1) DMQ2K1V MT DTT DMQ2K1V MA Inhibitor DMQ2K1V RN Design, radiosynthesis, and biodistribution of a new potent and selective ligand for in vivo imaging of the adenosine A(2A) receptor system using p... J Med Chem. 2000 Nov 16;43(23):4359-62. DMQ2K1V RU https://pubmed.ncbi.nlm.nih.gov/11087559 DMQ2K1V DI DMQ2K1V DMQ2K1V DN SCH-442416 DMQ2K1V MI TTM2AOE DMQ2K1V MN Adenosine A2a receptor (ADORA2A) DMQ2K1V MT DTT DMQ2K1V MA Inhibitor DMQ2K1V RN Design, radiosynthesis, and biodistribution of a new potent and selective ligand for in vivo imaging of the adenosine A(2A) receptor system using p... J Med Chem. 2000 Nov 16;43(23):4359-62. DMQ2K1V RU https://pubmed.ncbi.nlm.nih.gov/11087559 DMQ2K1V DI DMQ2K1V DMQ2K1V DN SCH-442416 DMQ2K1V MI TTJFY5U DMQ2K1V MN Adenosine A3 receptor (ADORA3) DMQ2K1V MT DTT DMQ2K1V MA Inhibitor DMQ2K1V RN Synthesis and evaluation of 1,2,4-triazolo[1,5-c]pyrimidine derivatives as A2A receptor-selective antagonists. Bioorg Med Chem Lett. 2010 Oct 1;20(19):5690-4. DMQ2K1V RU https://pubmed.ncbi.nlm.nih.gov/20801028 DMDP6UF DI DMDP6UF DMDP6UF DN SCH-721015 DMDP6UF MI TTSIUJ9 DMDP6UF MN Interferon-alpha 2 (IFNA2) DMDP6UF MT DTT DMDP6UF MA Modulator DMDP6UF RN Toxicity and exposure of an adenovirus containing human interferon alpha-2b following intracystic administration in cynomolgus monkeys. Gene Ther. 2012 Jul;19(7):742-51. DMDP6UF RU https://pubmed.ncbi.nlm.nih.gov/21900961 DM7A6R5 DI DM7A6R5 DM7A6R5 DN SCH-900117 DM7A6R5 MI TTG0MT6 DM7A6R5 MN Interleukin-17 (IL17) DM7A6R5 MT DTT DM7A6R5 MA Modulator DM7A6R5 RN Targeting IL-17 and TH17 cells in chronic inflammation. Nat Rev Drug Discov. 2012 Oct;11(10):763-76. DM7A6R5 RU https://pubmed.ncbi.nlm.nih.gov/23023676 DMRD1IW DI DMRD1IW DMRD1IW DN SCO-088 DMRD1IW MI TTS7G69 DMRD1IW MN Fusion protein Bcr-Abl (Bcr-Abl) DMRD1IW MT DTT DMRD1IW MA Inhibitor DMRD1IW RN Clinical pipeline report, company report or official report of Sun Pharma Advanced Research Company. DMRD1IW RU https://www.sparc.life/research-programs/sco-088 DMB1MZS DI DMB1MZS DMB1MZS DN SCO-120 DMB1MZS MI TTZAYWL DMB1MZS MN Estrogen receptor (ESR) DMB1MZS MT DTT DMB1MZS MA Degrader DMB1MZS RN Clinical pipeline report, company report or official report of Sun Pharma Advanced Research Company. DMB1MZS RU https://www.sparc.life/research-programs/sco-120 DMU0Q6L DI DMU0Q6L DMU0Q6L DN SDX-7320 DMU0Q6L MI TTZL0OI DMU0Q6L MN Methionine aminopeptidase 2 (METAP2) DMU0Q6L MT DTT DMU0Q6L MA Inhibitor DMU0Q6L RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMU0Q6L RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DMU9ZGN DI DMU9ZGN DMU9ZGN DN SDZ-GPI-562 DMU9ZGN MI TT38RM1 DMU9ZGN MN Glycoprotein IIb/IIIa receptor (GPIIb/IIIa) DMU9ZGN MT DTT DMU9ZGN MA Modulator DMU9ZGN RN Heparin-induced thrombocytopenia: the role of platelet activation and therapeutic implications. Semin Thromb Hemost. 1999;25 Suppl 1:67-75. DMU9ZGN RU https://www.ncbi.nlm.nih.gov/pubmed/10357155 DM8SINB DI DM8SINB DM8SINB DN SDZ-LAV-694 DM8SINB MI TTML2WA DM8SINB MN Tubulin (TUB) DM8SINB MT DTT DM8SINB MA Inhibitor DM8SINB RN Recent Patents Reveal Microtubules as Persistent Promising Target for Novel Drug Development for Cancers. Recent Patents on Anti-Infective Drug Discovery 12/2009; 4(3):164-82. DM8SINB RU http://www.researchgate.net/profile/Harish_Joshi/publication/26735183_Recent_patents_reveal_microtubules_as_persistent_promising_target_for_novel_drug_development_for_cancers/links/0deec5192b302d6e79000000.pdf DML6QJN DI DML6QJN DML6QJN DN SDZ-MKS-492 DML6QJN MI TTZCG4L DML6QJN MN Phosphodiesterase 3 (PDE3) DML6QJN MT DTT DML6QJN MA Modulator DML6QJN RN Effects of a cyclic nucleotide phosphodiesterase isoenzyme type III inhibitor, SDZ MKS 492 on airway responsiveness in beagles. Arerugi. 1993 Aug;42(8):920-5. DML6QJN RU https://pubmed.ncbi.nlm.nih.gov/8250732 DMX94YF DI DMX94YF DMX94YF DN SEA-CD70 DMX94YF MI TTNCIE0 DMX94YF MN CD70 antigen (CD27-L) DMX94YF MT DTT DMX94YF MA Inhibitor DMX94YF RN Clinical pipeline report, company report or official report of Seagen. DMX94YF RU https://www.seagen.com/science/pipeline DM7GUH3 DI DM7GUH3 DM7GUH3 DN SEA-TGT DM7GUH3 MI TTWNL74 DM7GUH3 MN V-set and immunoglobulin domain-containing protein 9 (TIGIT) DM7GUH3 MT DTT DM7GUH3 MA Inhibitor DM7GUH3 RN Clinical pipeline report, company report or official report of Seagen. DM7GUH3 RU https://www.seagen.com/science/pipeline DMCP7SD DI DMCP7SD DMCP7SD DN Seclidemstat DMCP7SD MI TTNR0UQ DMCP7SD MN Lysine-specific histone demethylase 1 (LSD) DMCP7SD MT DTT DMCP7SD MA Inhibitor DMCP7SD RN Scaffolding LSD1 Inhibitors Impair NK Cell Metabolism and Cytotoxic Function Through Depletion of Glutathione. Front Immunol. 2020 Sep 17;11:2196. DMCP7SD RU https://pubmed.ncbi.nlm.nih.gov/33042135 DMHCUZV DI DMHCUZV DMHCUZV DN SEL120 DMHCUZV MI TTNABU9 DMHCUZV MN Cyclin-dependent kinase 19 (CDK19) DMHCUZV MT DTT DMHCUZV MA Inhibitor DMHCUZV RN Clinical pipeline report, company report or official report of Ryvu Therapeutics. DMHCUZV RU https://ryvu.com/pipeline/ DMHCUZV DI DMHCUZV DMHCUZV DN SEL120 DMHCUZV MI TTBJR4L DMHCUZV MN Cyclin-dependent kinase 8 (CDK8) DMHCUZV MT DTT DMHCUZV MA Inhibitor DMHCUZV RN Clinical pipeline report, company report or official report of Ryvu Therapeutics. DMHCUZV RU https://ryvu.com/pipeline/ DMF89ZT DI DMF89ZT DMF89ZT DN SEP-228432 DMF89ZT MI TT3ROYC DMF89ZT MN Serotonin transporter (SERT) DMF89ZT MT DTT DMF89ZT MA Inhibitor DMF89ZT RN Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800028715) DMF89ZT RU http://adisinsight.springer.com/drugs/800028715 DMTZ983 DI DMTZ983 DMTZ983 DN SER-101 DMTZ983 MI TT07C3Y DMTZ983 MN 5-HT 4 receptor (HTR4) DMTZ983 MT DTT DMTZ983 MA Antagonist DMTZ983 RN Phase I clinical trail of SER101 (RO1160367) for treating heart failure leukemia. Roche. DMTZ983 RU http://www.biocentury.com/products/ser101 DMD2GKF DI DMD2GKF DMD2GKF DN SFLT-01 DMD2GKF MI TT48I1Y DMD2GKF MN Placenta growth factor (PlGF) DMD2GKF MT DTT DMD2GKF MA Modulator DMD2GKF RN sFLT01: a novel fusion protein with antiangiogenic activity. Mol Cancer Ther. 2011 Mar;10(3):404-15. DMD2GKF RU https://pubmed.ncbi.nlm.nih.gov/21252283 DMD2GKF DI DMD2GKF DMD2GKF DN SFLT-01 DMD2GKF MI TTOHSBA DMD2GKF MN Vascular endothelial growth factor A (VEGFA) DMD2GKF MT DTT DMD2GKF MA Modulator DMD2GKF RN sFLT01: a novel fusion protein with antiangiogenic activity. Mol Cancer Ther. 2011 Mar;10(3):404-15. DMD2GKF RU https://pubmed.ncbi.nlm.nih.gov/21252283 DMDAHEL DI DMDAHEL DMDAHEL DN SGM-1019 DMDAHEL MI TT473XN DMDAHEL MN P2X purinoceptor 7 (P2RX7) DMDAHEL MT DTT DMDAHEL MA Modulator DMDAHEL RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMDAHEL RU http://phrma-docs.phrma.org/files/dmfile/medicines-in-development-drug-list-autoimmune-diseases.pdf DMVBQ2L DI DMVBQ2L DMVBQ2L DN SGN LIV1A DMVBQ2L MI TTZN1CF DMVBQ2L MN Solute carrier family 39 member 6 (SLC39A6) DMVBQ2L MT DTT DMVBQ2L RN SGN-LIV1A: a novel antibody-drug conjugate targeting LIV-1 for the treatment of metastatic breast cancer. Mol Cancer Ther. 2014 Dec;13(12):2991-3000. DMVBQ2L RU https://pubmed.ncbi.nlm.nih.gov/25253783 DMXA7W9 DI DMXA7W9 DMXA7W9 DN SGN-70 DMXA7W9 MI TTNCIE0 DMXA7W9 MN CD70 antigen (CD27-L) DMXA7W9 MT DTT DMXA7W9 RN 2011 Pipeline of Seattle Genetics. DMXA7W9 RU http://www.seagen.com/product_pipeline.php DMATJL9 DI DMATJL9 DMATJL9 DN SGN-B6A DMATJL9 MI TTKQSXZ DMATJL9 MN Integrin beta-6 (ITGB6) DMATJL9 MT DTT DMATJL9 RN Clinical pipeline report, company report or official report of Seagen. DMATJL9 RU https://www.seagen.com/science/pipeline DMSVD2R DI DMSVD2R DMSVD2R DN SGN-CD228A DMSVD2R MI TT8OBT3 DMSVD2R MN Melanotransferrin (MELTF) DMSVD2R MT DTT DMSVD2R RN Clinical pipeline report, company report or official report of Seagen. DMSVD2R RU https://www.seagen.com/science/pipeline DMKW10G DI DMKW10G DMKW10G DN SGN-CD30C DMKW10G MI TT2GM5R DMKW10G MN Lymphocyte activation antigen CD30 (TNFRSF8) DMKW10G MT DTT DMKW10G RN Clinical pipeline report, company report or official report of Seagen. DMKW10G RU https://www.seagen.com/science/pipeline DMMJ1PO DI DMMJ1PO DMMJ1PO DN SGN-CD70A DMMJ1PO MI TTNCIE0 DMMJ1PO MN CD70 antigen (CD27-L) DMMJ1PO MT DTT DMMJ1PO RN SGN-CD70A, a novel and highly potent anti-CD70 ADC, induces double-strand DNA breaks and is active in models of MDR+ renal cell carcinoma (RCC) and non-Hodgkin lymphoma (NHL). Cancer Research 10/2014; 74(19 Supplement):2647-2647. DMMJ1PO RU http://cancerres.aacrjournals.org/content/74/19_Supplement/2647 DM3RSMF DI DM3RSMF DM3RSMF DN Sgx523 DM3RSMF MI DEAWHS8 DM3RSMF MN Aldehyde oxidase (AOX1) DM3RSMF MT DME DM3RSMF MA Metabolism DM3RSMF RN Species-specific metabolism of SGX523 by aldehyde oxidase and the toxicological implications. Drug Metab Dispos. 2010 Aug;38(8):1277-85. DM3RSMF RU https://www.ncbi.nlm.nih.gov/pubmed/?term=20421447 DM3RSMF DI DM3RSMF DM3RSMF DN Sgx523 DM3RSMF MI TTNDSF4 DM3RSMF MN Proto-oncogene c-Met (MET) DM3RSMF MT DTT DM3RSMF MA Inhibitor DM3RSMF RN CenterWatch. Drugs in Clinical Trials Database. CenterWatch. 2008. DM3RSMF RU http://www.centerwatch.com/ DMO0CA8 DI DMO0CA8 DMO0CA8 DN SHP616 DMO0CA8 MI TT7LRQH DMO0CA8 MN Complement C1s component (C1S) DMO0CA8 MT DTT DMO0CA8 MA Inhibitor DMO0CA8 RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMO0CA8 RU http://phrma-docs.phrma.org/files/dmfile/medicines-in-development-drug-list-autoimmune-diseases.pdf DMGFTAI DI DMGFTAI DMGFTAI DN SHR0534 DMGFTAI MI TTB8FUC DMGFTAI MN Free fatty acid receptor 1 (GPR40) DMGFTAI MT DTT DMGFTAI MA Agonist DMGFTAI RN Targeting metabolic dysregulation for fibrosis therapy. Nat Rev Drug Discov. 2020 Jan;19(1):57-75. DMGFTAI RU https://pubmed.ncbi.nlm.nih.gov/31548636 DMGFTAI DI DMGFTAI DMGFTAI DN SHR0534 DMGFTAI MI TTG0MQD DMGFTAI MN Inflammation-related GPCR EX33 (GPR84) DMGFTAI MT DTT DMGFTAI MA Agonist DMGFTAI RN Targeting metabolic dysregulation for fibrosis therapy. Nat Rev Drug Discov. 2020 Jan;19(1):57-75. DMGFTAI RU https://pubmed.ncbi.nlm.nih.gov/31548636 DMDSFEB DI DMDSFEB DMDSFEB DN SI-B001 DMDSFEB MI TTGKNB4 DMDSFEB MN Epidermal growth factor receptor (EGFR) DMDSFEB MT DTT DMDSFEB RN Clinical pipeline report, company report or official report of SystImmune. DMDSFEB RU https://systimmune.com/pipeline.html DMDSFEB DI DMDSFEB DMDSFEB DN SI-B001 DMDSFEB MI TTDC8N2 DMDSFEB MN Erbb3 tyrosine kinase receptor (Erbb-3) DMDSFEB MT DTT DMDSFEB RN Clinical pipeline report, company report or official report of SystImmune. DMDSFEB RU https://systimmune.com/pipeline.html DMJW5R0 DI DMJW5R0 DMJW5R0 DN SI-B003 DMJW5R0 MI TTI2S1D DMJW5R0 MN Cytotoxic T-lymphocyte protein 4 (CTLA-4) DMJW5R0 MT DTT DMJW5R0 RN Clinical pipeline report, company report or official report of SystImmune. DMJW5R0 RU https://systimmune.com/pipeline.html DMJW5R0 DI DMJW5R0 DMJW5R0 DN SI-B003 DMJW5R0 MI TTNBFWK DMJW5R0 MN Programmed cell death protein 1 (PD-1) DMJW5R0 MT DTT DMJW5R0 RN Clinical pipeline report, company report or official report of SystImmune. DMJW5R0 RU https://systimmune.com/pipeline.html DMFK7UR DI DMFK7UR DMFK7UR DN Simotaxel DMFK7UR MI TTYFKSZ DMFK7UR MN Tubulin beta (TUBB) DMFK7UR MT DTT DMFK7UR MA Inhibitor DMFK7UR RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2640). DMFK7UR RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2640 DMG7XKP DI DMG7XKP DMG7XKP DN SKF-105494 DMG7XKP MI TTYCILE DMG7XKP MN Vasopressin receptor (VR) DMG7XKP MT DTT DMG7XKP MA Modulator DMG7XKP RN Modulation of vasopressin antidiuretic action by alpha 2-adrenoceptors is species specific. Am J Physiol. 1991 Nov;261(5 Pt 2):R1242-6. DMG7XKP RU https://pubmed.ncbi.nlm.nih.gov/1659234 DMUN7EQ DI DMUN7EQ DMUN7EQ DN SKF-105809 DMUN7EQ MI TT2J34L DMUN7EQ MN Arachidonate 5-lipoxygenase (5-LOX) DMUN7EQ MT DTT DMUN7EQ MA Inhibitor DMUN7EQ RN Analgetic activity of SK&F 105809, a dual inhibitor of arachidonic acid metabolism. Agents Actions Suppl. 1991;32:113-7. DMUN7EQ RU https://pubmed.ncbi.nlm.nih.gov/1906235 DMUN7EQ DI DMUN7EQ DMUN7EQ DN SKF-105809 DMUN7EQ MI TTK0943 DMUN7EQ MN Prostaglandin G/H synthase (COX) DMUN7EQ MT DTT DMUN7EQ MA Modulator DMUN7EQ RN Analgetic activity of SK&F 105809, a dual inhibitor of arachidonic acid metabolism. Agents Actions Suppl. 1991;32:113-7. DMUN7EQ RU https://pubmed.ncbi.nlm.nih.gov/1906235 DM4I92Z DI DM4I92Z DM4I92Z DN SKI-G-801 DM4I92Z MI TTGJCWZ DM4I92Z MN Fms-like tyrosine kinase 3 (FLT-3) DM4I92Z MT DTT DM4I92Z MA Inhibitor DM4I92Z RN Clinical pipeline report, company report or official report of Genosco. DM4I92Z RU http://genosco.com/pipeline/ski-g-801/ DMTSKXR DI DMTSKXR DMTSKXR DN SKI-O-703 DMTSKXR MI TTOU65C DMTSKXR MN Tyrosine-protein kinase SYK (SYK) DMTSKXR MT DTT DMTSKXR MA Inhibitor DMTSKXR RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMTSKXR RU http://phrma-docs.phrma.org/files/dmfile/medicines-in-development-drug-list-autoimmune-diseases.pdf DMW64UZ DI DMW64UZ DMW64UZ DN SKL-10406 DMW64UZ MI TTJQOD7 DMW64UZ MN 5-HT 2A receptor (HTR2A) DMW64UZ MT DTT DMW64UZ MA Binder DMW64UZ RN Bi-directional modulation of BNST neurons by 5-HT: Molecular expression and functional properties of excitatory 5-HT receptor subtypes. Neuroscience. 2009 December 29; 164(4): 1776-1793. DMW64UZ RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2783788/ DMW64UZ DI DMW64UZ DMW64UZ DN SKL-10406 DMW64UZ MI TTEX248 DMW64UZ MN Dopamine D2 receptor (D2R) DMW64UZ MT DTT DMW64UZ MA Binder DMW64UZ RN Bi-directional modulation of BNST neurons by 5-HT: Molecular expression and functional properties of excitatory 5-HT receptor subtypes. Neuroscience. 2009 December 29; 164(4): 1776-1793. DMW64UZ RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2783788/ DM8YNI6 DI DM8YNI6 DM8YNI6 DN SKL-PSY DM8YNI6 MI TTSQIFT DM8YNI6 MN 5-HT 1A receptor (HTR1A) DM8YNI6 MT DTT DM8YNI6 MA Modulator DM8YNI6 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1). DM8YNI6 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1 DMN3D72 DI DMN3D72 DMN3D72 DN SL-172154 DMN3D72 MI TTN6Y9A DMN3D72 MN CD40L receptor (CD40) DMN3D72 MT DTT DMN3D72 MA Inhibitor DMN3D72 RN Clinical pipeline report, company report or official report of Shattuck Labs. DMN3D72 RU https://www.shattucklabs.com/pipeline/overview/ DMN3D72 DI DMN3D72 DMN3D72 DN SL-172154 DMN3D72 MI TT28S46 DMN3D72 MN Leukocyte surface antigen CD47 (CD47) DMN3D72 MT DTT DMN3D72 MA Inhibitor DMN3D72 RN Clinical pipeline report, company report or official report of Shattuck Labs. DMN3D72 RU https://www.shattucklabs.com/pipeline/overview/ DMIVGYK DI DMIVGYK DMIVGYK DN SL-801 DMIVGYK MI TTCJUR4 DMIVGYK MN Exportin-1 (XPO1) DMIVGYK MT DTT DMIVGYK MA Inhibitor DMIVGYK RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMIVGYK RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DMVUL1H DI DMVUL1H DMVUL1H DN Sleeping Beauty CAR-TCR DMVUL1H MI TTW640A DMVUL1H MN B-lymphocyte surface antigen B4 (CD19) DMVUL1H MT DTT DMVUL1H RN Clinical pipeline report, company report or official report of Ziopharm Oncology. DMVUL1H RU https://ziopharm.com/pipeline/ DMIAOU6 DI DMIAOU6 DMIAOU6 DN SLN124 DMIAOU6 MI TTNIUKC DMIAOU6 MN TMPRSS6 messenger RNA (TMPRSS6 mRNA) DMIAOU6 MT DTT DMIAOU6 MA Inhibitor DMIAOU6 RN SLN124, a GalNAc-siRNA Conjugate Targeting TMPRSS6, Efficiently Prevents Iron Overload in Hereditary Haemochromatosis Type 1. Hemasphere. 2019 Oct 1;3(6):e301. DMIAOU6 RU https://pubmed.ncbi.nlm.nih.gov/31976476 DM7WKTM DI DM7WKTM DM7WKTM DN SLV-338 DM7WKTM MI TT1BGDH DM7WKTM MN Endothelin-converting enzyme (ECE) DM7WKTM MT DTT DM7WKTM MA Modulator DM7WKTM RN Renoprotective effects of combined endothelin-converting enzyme/neutral endopeptidase inhibitor SLV338 in acute and chronic experimental renal damage. Clin Lab. 2011;57(7-8):507-15. DM7WKTM RU https://pubmed.ncbi.nlm.nih.gov/21888014 DM7WKTM DI DM7WKTM DM7WKTM DN SLV-338 DM7WKTM MI TT5TKPM DM7WKTM MN Neutral endopeptidase (MME) DM7WKTM MT DTT DM7WKTM MA Modulator DM7WKTM RN Renoprotective effects of combined endothelin-converting enzyme/neutral endopeptidase inhibitor SLV338 in acute and chronic experimental renal damage. Clin Lab. 2011;57(7-8):507-15. DM7WKTM RU https://pubmed.ncbi.nlm.nih.gov/21888014 DM491NI DI DM491NI DM491NI DN SM04755 DM491NI MI TTFPSHI DM491NI MN Wnt signaling pathway (Wnt pathway) DM491NI MT DTT DM491NI MA Modulator DM491NI RN A Phase 1, Open-Label, Dose-Escalation, Dose-Finding Study Evaluating the Safety and Pharmacokinetics of SM04755 in Subjects with Advanced Colorectal, Gastric, Hepatic, or Pancreatic Cancer. DM491NI RU https://clinicaltrials.gov/ct2/show/NCT02191761?term=NCT02191761&rank=1 DM4KLNA DI DM4KLNA DM4KLNA DN SM08502 DM4KLNA MI TTFPSHI DM4KLNA MN Wnt signaling pathway (Wnt pathway) DM4KLNA MT DTT DM4KLNA MA Inhibitor DM4KLNA RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DM4KLNA RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DM73YG5 DI DM73YG5 DM73YG5 DN SM09419 DM73YG5 MI TT6K9BV DM73YG5 MN Cdc-like kinase (CLK) DM73YG5 MT DTT DM73YG5 MA Inhibitor DM73YG5 RN SM09419, a Novel, Small-Molecule CDC-like Kinase (CLK) Inhibitor, Demonstrates Strong Inhibition of the Wnt Signaling Pathway and Antitumor Effects in FMS-like Tyrosine Kinase 3 (FLT3)-Mutant Acute Myeloid Leukemia Models. Blood; 2019,134 (Supplement_1):1377. DM73YG5 RU https://doi.org/10.1182/blood-2019-130500 DM8L1GJ DI DM8L1GJ DM8L1GJ DN SNA-125 DM8L1GJ MI TTT7PJU DM8L1GJ MN Janus kinase 3 (JAK-3) DM8L1GJ MT DTT DM8L1GJ MA Inhibitor DM8L1GJ RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DM8L1GJ RU http://phrma-docs.phrma.org/files/dmfile/MID_Skin_Diseases_2018_9_FINAL.pdf DM8ZROW DI DM8ZROW DM8ZROW DN SNDX-6352 DM8ZROW MI TT7MRDV DM8ZROW MN Macrophage colony-stimulating factor 1 receptor (CSF1R) DM8ZROW MT DTT DM8ZROW MA Antagonist DM8ZROW RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DM8ZROW RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DMEITAS DI DMEITAS DMEITAS DN SNS-032 DMEITAS MI TT7HF4W DMEITAS MN Cyclin-dependent kinase 2 (CDK2) DMEITAS MT DTT DMEITAS MA Inhibitor DMEITAS RN Mechanism of action of SNS-032, a novel cyclin-dependent kinase inhibitor, in chronic lymphocytic leukemia. Blood. 2009 May 7;113(19):4637-45. DMEITAS RU https://pubmed.ncbi.nlm.nih.gov/19234140 DMEITAS DI DMEITAS DMEITAS DN SNS-032 DMEITAS MI TTQYF7G DMEITAS MN Cyclin-dependent kinase 7 (CDK7) DMEITAS MT DTT DMEITAS MA Inhibitor DMEITAS RN Mechanism of action of SNS-032, a novel cyclin-dependent kinase inhibitor, in chronic lymphocytic leukemia. Blood. 2009 May 7;113(19):4637-45. DMEITAS RU https://pubmed.ncbi.nlm.nih.gov/19234140 DMEITAS DI DMEITAS DMEITAS DN SNS-032 DMEITAS MI TT1LVF2 DMEITAS MN Cyclin-dependent kinase 9 (CDK9) DMEITAS MT DTT DMEITAS MA Inhibitor DMEITAS RN Mechanism of action of SNS-032, a novel cyclin-dependent kinase inhibitor, in chronic lymphocytic leukemia. Blood. 2009 May 7;113(19):4637-45. DMEITAS RU https://pubmed.ncbi.nlm.nih.gov/19234140 DMAC5F2 DI DMAC5F2 DMAC5F2 DN SNS-314 DMAC5F2 MI TTPS3C0 DMAC5F2 MN Aurora kinase A (AURKA) DMAC5F2 MT DTT DMAC5F2 MA Inhibitor DMAC5F2 RN SNS-314, a pan-Aurora kinase inhibitor, shows potent anti-tumor activity and dosing flexibility in vivo. Cancer Chemother Pharmacol. 2010 Mar;65(4):707-17. DMAC5F2 RU https://pubmed.ncbi.nlm.nih.gov/19649632 DMAC5F2 DI DMAC5F2 DMAC5F2 DN SNS-314 DMAC5F2 MI TT5LS6T DMAC5F2 MN Aurora kinase B (AURKB) DMAC5F2 MT DTT DMAC5F2 MA Inhibitor DMAC5F2 RN SNS-314, a pan-Aurora kinase inhibitor, shows potent anti-tumor activity and dosing flexibility in vivo. Cancer Chemother Pharmacol. 2010 Mar;65(4):707-17. DMAC5F2 RU https://pubmed.ncbi.nlm.nih.gov/19649632 DMAC5F2 DI DMAC5F2 DMAC5F2 DN SNS-314 DMAC5F2 MI TTLYXIT DMAC5F2 MN Aurora kinase C (AURKC) DMAC5F2 MT DTT DMAC5F2 MA Inhibitor DMAC5F2 RN SNS-314, a pan-Aurora kinase inhibitor, shows potent anti-tumor activity and dosing flexibility in vivo. Cancer Chemother Pharmacol. 2010 Mar;65(4):707-17. DMAC5F2 RU https://pubmed.ncbi.nlm.nih.gov/19649632 DMCGPU8 DI DMCGPU8 DMCGPU8 DN SNX281 DMCGPU8 MI TTT402Y DMCGPU8 MN Stimulator of interferon genes protein (TMEM173) DMCGPU8 MT DTT DMCGPU8 MA Inhibitor DMCGPU8 RN Clinical pipeline report, company report or official report of Silicon Therapeutics. DMCGPU8 RU https://silicontx.com/therapeutics-and-pipeline/targets/sting-agonist/ DMB3WJF DI DMB3WJF DMB3WJF DN Solulin DMB3WJF MI TT6L509 DMB3WJF MN Coagulation factor IIa (F2) DMB3WJF MT DTT DMB3WJF MA Modulator DMB3WJF RN The thrombomodulin analog Solulin promotes reperfusion and reduces infarct volume in a thrombotic stroke model. J Thromb Haemost. 2011 Jun;9(6):1174-82. DMB3WJF RU https://pubmed.ncbi.nlm.nih.gov/21645225 DMB3YZJ DI DMB3YZJ DMB3YZJ DN Sonepcizumab DMB3YZJ MI TT9JZCK DMB3YZJ MN Sphingosine-1-phosphate receptor 1 (S1PR1) DMB3YZJ MT DTT DMB3YZJ RN Targeting the sphingosine-1-phosphate axis in cancer, inflammation and beyond. Nat Rev Drug Discov. 2013 Sep;12(9):688-702. DMB3YZJ RU https://pubmed.ncbi.nlm.nih.gov/23954895 DMBKL6O DI DMBKL6O DMBKL6O DN SOR-C13 DMBKL6O MI TTBK14N DMBKL6O MN Transient receptor potential cation channel V6 (TRPV6) DMBKL6O MT DTT DMBKL6O MA Inhibitor DMBKL6O RN In vivo detection of human TRPV6-rich tumors with anti-cancer peptides derived from soricidin. PLoS One. 2013;8(3):e58866. DMBKL6O RU https://pubmed.ncbi.nlm.nih.gov/23554944 DMAD6HS DI DMAD6HS DMAD6HS DN SPC4955 DMAD6HS MI TT2718H DMAD6HS MN Apolipoprotein B-100 (APOB) DMAD6HS MT DTT DMAD6HS MA Inhibitor DMAD6HS RN 2011 Pipeline of Santaris Pharma. DMAD6HS RU http://www.santaris.com/product-pipeline DMUPQ70 DI DMUPQ70 DMUPQ70 DN SPC5001 DMUPQ70 MI TTBRG7E DMUPQ70 MN Proprotein convertase subtilisin/kexin type 9 (PCSK9) DMUPQ70 MT DTT DMUPQ70 MA Inhibitor DMUPQ70 RN 2011 Pipeline of Santaris Pharma. DMUPQ70 RU http://www.santaris.com/product-pipeline DMO1FTI DI DMO1FTI DMO1FTI DN Sphingosine DMO1FTI MI TTUAIKM DMO1FTI MN Cholinephosphate cytidylyltransferase (PCYT1B) DMO1FTI MT DTT DMO1FTI MA Inhibitor DMO1FTI RN Sphingosine inhibits the activity of rat liver CTP:phosphocholine cytidylyltransferase. J Biol Chem. 1990 Jul 15;265(20):11746-50. DMO1FTI RU https://pubmed.ncbi.nlm.nih.gov/2164014 DMJCQKA DI DMJCQKA DMJCQKA DN Sphingosine-1-Phosphate DMJCQKA MI DTI7UX6 DMJCQKA MN Breast cancer resistance protein (ABCG2) DMJCQKA MT DTP DMJCQKA MA Substrate DMJCQKA RN Estradiol induces export of sphingosine 1-phosphate from breast cancer cells via ABCC1 and ABCG2. J Biol Chem. 2010 Apr 2;285(14):10477-86. DMJCQKA RU http://www.ncbi.nlm.nih.gov/pubmed/20110355 DMJCQKA DI DMJCQKA DMJCQKA DN Sphingosine-1-Phosphate DMJCQKA MI DTUGYRD DMJCQKA MN P-glycoprotein 1 (ABCB1) DMJCQKA MT DTP DMJCQKA MA Substrate DMJCQKA RN Lipid dependence of ABC transporter localization and function. Chem Phys Lipids. 2009 Oct;161(2):57-64. DMJCQKA RU https://doi.org/10.1016/j.chemphyslip.2009.07.004 DMJCQKA DI DMJCQKA DMJCQKA DN Sphingosine-1-Phosphate DMJCQKA MI DE6WXTH DMJCQKA MN Phospholipid phosphatase 1 (PLPP1) DMJCQKA MT DME DMJCQKA MA Metabolism DMJCQKA RN Lipid phosphate phosphatase 3 regulates adipocyte sphingolipid synthesis, but not developmental adipogenesis or diet-induced obesity in mice. PLoS One. 2018 Jun 11;13(6):e0198063. DMJCQKA RU https://www.ncbi.nlm.nih.gov/pubmed/?term=29889835 DMJCQKA DI DMJCQKA DMJCQKA DN Sphingosine-1-Phosphate DMJCQKA MI DT3Q1UO DMJCQKA MN Protein spinster homolog 2 (SLC63A2) DMJCQKA MT DTP DMJCQKA MA Substrate DMJCQKA RN The ABCs of membrane transporters in health and disease (SLC series): Introduction. Molecular Aspects of Medicine, 2013, 34(2-3):95-107. (GeneName=SLC63A2) DMJCQKA RU http://slc.bioparadigms.org/protein?GeneName=SLC63A2 DMJCQKA DI DMJCQKA DMJCQKA DN Sphingosine-1-Phosphate DMJCQKA MI DELSNWC DMJCQKA MN Sphingosine kinase 1 (SPHK1) DMJCQKA MT DME DMJCQKA MA Metabolism DMJCQKA RN Phosphorylation of the immunomodulatory drug FTY720 by sphingosine kinases. J Biol Chem. 2003 Nov 28;278(48):47408-15. DMJCQKA RU https://www.ncbi.nlm.nih.gov/pubmed/?term=13129923 DMJCQKA DI DMJCQKA DMJCQKA DN Sphingosine-1-Phosphate DMJCQKA MI DES1RUQ DMJCQKA MN Sphingosine kinase 2 (SPHK2) DMJCQKA MT DME DMJCQKA MA Metabolism DMJCQKA RN Phosphorylation of the immunomodulatory drug FTY720 by sphingosine kinases. J Biol Chem. 2003 Nov 28;278(48):47408-15. DMJCQKA RU https://www.ncbi.nlm.nih.gov/pubmed/?term=13129923 DMJCQKA DI DMJCQKA DMJCQKA DN Sphingosine-1-Phosphate DMJCQKA MI TT9JZCK DMJCQKA MN Sphingosine-1-phosphate receptor 1 (S1PR1) DMJCQKA MT DTT DMJCQKA MA Inhibitor DMJCQKA RN Exploration of amino alcohol derivatives as novel, potent, and highly selective sphingosine-1-phosphate receptor subtype-1 agonists. Bioorg Med Chem Lett. 2010 Apr 15;20(8):2520-4. DMJCQKA RU https://pubmed.ncbi.nlm.nih.gov/20304639 DM5IPUS DI DM5IPUS DM5IPUS DN SPI-014 DM5IPUS MI TT9W8GU DM5IPUS MN Gamma-secretase (GS) DM5IPUS MT DTT DM5IPUS MA Modulator DM5IPUS RN Modulation of gamma-secretase for the treatment of Alzheimer's disease. Int J Alzheimers Dis. 2012;2012:210756. DM5IPUS RU https://pubmed.ncbi.nlm.nih.gov/23320246 DM8O2AQ DI DM8O2AQ DM8O2AQ DN SPN-803 DM8O2AQ MI TT0EOB8 DM8O2AQ MN B-Raf messenger RNA (BRAF mRNA) DM8O2AQ MT DTT DM8O2AQ RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1943). DM8O2AQ RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1943 DM8O2AQ DI DM8O2AQ DM8O2AQ DN SPN-803 DM8O2AQ MI TTAN5W2 DM8O2AQ MN Raf messenger RNA (Raf mRNA) DM8O2AQ MT DTT DM8O2AQ MA Inhibitor DM8O2AQ RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2184). DM8O2AQ RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2184 DMO5760 DI DMO5760 DMO5760 DN SR13668 DMO5760 MI TTAZ05C DMO5760 MN RAC-gamma serine/threonine-protein kinase (AKT3) DMO5760 MT DTT DMO5760 MA Modulator DMO5760 RN Phase 0 clinical chemoprevention trial of the Akt inhibitor SR13668. Cancer Prev Res (Phila). 2011 Mar;4(3):347-53. DMO5760 RU https://pubmed.ncbi.nlm.nih.gov/21372034 DMYRPBI DI DMYRPBI DMYRPBI DN SR-4554 DMYRPBI MI TT5XVD6 DMYRPBI MN Intracellular nitroreductase (INR) DMYRPBI MT DTT DMYRPBI MA Modulator DMYRPBI RN A phase I study of SR-4554 via intravenous administration for noninvasive investigation of tumor hypoxia by magnetic resonance spectroscopy in patients with malignancy. Clin Cancer Res. 2003 Nov 1;9(14):5101-12. DMYRPBI RU https://pubmed.ncbi.nlm.nih.gov/14613987 DMQMO4N DI DMQMO4N DMQMO4N DN SRF388 DMQMO4N MI TTC5LTG DMQMO4N MN Interleukin-27 (IL27) DMQMO4N MT DTT DMQMO4N RN Clinical pipeline report, company report or official report of Surface oncology. DMQMO4N RU https://www.surfaceoncology.com/pipeline-programs/ DMTK1BV DI DMTK1BV DMTK1BV DN SRF617 DMTK1BV MI TTYM8DJ DMTK1BV MN Ectonucleoside triphosphate diphosphohydrolase 1 (CD39) DMTK1BV MT DTT DMTK1BV RN Clinical pipeline report, company report or official report of Surface oncology. DMTK1BV RU https://www.surfaceoncology.com/pipeline-programs/ DM0EWMT DI DM0EWMT DM0EWMT DN SRK-181 DM0EWMT MI TTR9XHZ DM0EWMT MN Transforming growth factor beta 1 (TGFB1) DM0EWMT MT DTT DM0EWMT MA Inhibitor DM0EWMT RN Clinical pipeline report, company report or official report of Scholar Rock. DM0EWMT RU https://scholarrock.com/our-pipeline/oncology/ DM7DAKX DI DM7DAKX DM7DAKX DN SRT2379 DM7DAKX MI TTUF2HO DM7DAKX MN NAD-dependent deacetylase sirtuin-1 (SIRT1) DM7DAKX MT DTT DM7DAKX MA Modulator DM7DAKX RN SRT2379, a small-molecule SIRT1 activator, fails to reduce cytokine release in a human endotoxemia model. Critical Care 2013, 17(Suppl 4):P8. DM7DAKX RU http://www.ccforum.com/content/17/S4/P8 DMRAXFH DI DMRAXFH DMRAXFH DN SRT3025 DMRAXFH MI TTUF2HO DMRAXFH MN NAD-dependent deacetylase sirtuin-1 (SIRT1) DMRAXFH MT DTT DMRAXFH MA Modulator DMRAXFH RN The Sirt1 Activators SRT2183 and SRT3025 Inhibit RANKL-Induced Osteoclastogenesis in Bone Marrow-Derived Macrophages and Down-Regulate Sirt3 in Sirt1 Null Cells. PLoS One. 2015 Jul 30;10(7):e0134391. DMRAXFH RU https://pubmed.ncbi.nlm.nih.gov/26226624 DMO1N8A DI DMO1N8A DMO1N8A DN SRX-251 DMO1N8A MI TT4TFGN DMO1N8A MN Vasopressin V1a receptor (V1AR) DMO1N8A MT DTT DMO1N8A MA Antagonist DMO1N8A RN Orally active vasopressin V1a receptor antagonist, SRX251, selectively blocks aggressive behavior. Pharmacol Biochem Behav. 2006 Feb;83(2):169-74. DMO1N8A RU https://pubmed.ncbi.nlm.nih.gov/16504276 DMSUFW6 DI DMSUFW6 DMSUFW6 DN SSR-125047 DMSUFW6 MI TTFBNVI DMSUFW6 MN Aldose reductase (AKR1B1) DMSUFW6 MT DTT DMSUFW6 MA Inhibitor DMSUFW6 RN Aldose reductase inhibitors: an update. Ann Pharmacother. 1993 Jun;27(6):751-4. DMSUFW6 RU https://pubmed.ncbi.nlm.nih.gov/8329799 DMSUFW6 DI DMSUFW6 DMSUFW6 DN SSR-125047 DMSUFW6 MI TT5TPI6 DMSUFW6 MN Opioid receptor sigma 1 (OPRS1) DMSUFW6 MT DTT DMSUFW6 MA Binder DMSUFW6 RN The pipeline and future of drug development in schizophrenia. Mol Psychiatry. 2007 Oct;12(10):904-22. DMSUFW6 RU https://pubmed.ncbi.nlm.nih.gov/17667958 DMG6NI8 DI DMG6NI8 DMG6NI8 DN SSR-125329A DMG6NI8 MI TT5TPI6 DMG6NI8 MN Opioid receptor sigma 1 (OPRS1) DMG6NI8 MT DTT DMG6NI8 MA Binder DMG6NI8 RN SSR125329A, a high affinity sigma receptor ligand with potent anti-inflammatory properties. Eur J Pharmacol. 2002 Dec 5;456(1-3):123-31. DMG6NI8 RU https://pubmed.ncbi.nlm.nih.gov/12450578 DMOJA7N DI DMOJA7N DMOJA7N DN SSR-128428 DMOJA7N MI TT6L509 DMOJA7N MN Coagulation factor IIa (F2) DMOJA7N MT DTT DMOJA7N MA Modulator DMOJA7N RN Company report (Sanofi) (drug: FY2008) DMOJA7N RU http://en.sanofi.com/events/ceo_interview/docs/FY2008_EN_V5.pdf DMOJA7N DI DMOJA7N DMOJA7N DN SSR-128428 DMOJA7N MI TTCIHJA DMOJA7N MN Coagulation factor Xa (F10) DMOJA7N MT DTT DMOJA7N MA Modulator DMOJA7N RN Company report (Sanofi) (drug: FY2008) DMOJA7N RU http://en.sanofi.com/events/ceo_interview/docs/FY2008_EN_V5.pdf DMXQF1T DI DMXQF1T DMXQF1T DN SSR-181507 DMXQF1T MI TTSQIFT DMXQF1T MN 5-HT 1A receptor (HTR1A) DMXQF1T MT DTT DMXQF1T MA Modulator DMXQF1T RN SSR181507, a dopamine D receptor and 5-HT() receptor ligand: evidence for mixed anxiolytic- and antidepressant-like activities.Pharmacol Biochem Behav.2011 Jan;97(3):428-35. DMXQF1T RU https://www.ncbi.nlm.nih.gov/pubmed/20920519 DMXQF1T DI DMXQF1T DMXQF1T DN SSR-181507 DMXQF1T MI TTEX248 DMXQF1T MN Dopamine D2 receptor (D2R) DMXQF1T MT DTT DMXQF1T MA Modulator DMXQF1T RN SSR181507, a dopamine D receptor and 5-HT() receptor ligand: evidence for mixed anxiolytic- and antidepressant-like activities.Pharmacol Biochem Behav.2011 Jan;97(3):428-35. DMXQF1T RU https://www.ncbi.nlm.nih.gov/pubmed/20920519 DMX6V1L DI DMX6V1L DMX6V1L DN ST-1141 DMX6V1L MI TTWDC17 DMX6V1L MN Growth hormone secretagogue receptor 1 (GHSR) DMX6V1L MT DTT DMX6V1L MA Agonist DMX6V1L RN The Prokinetic Face of Ghrelin. International Journal of Peptides Volume 2010 (2010), Article ID 493614, Page(11). DMX6V1L RU http://www.hindawi.com/journals/ijpep/2010/493614/ DMGPIV0 DI DMGPIV0 DMGPIV0 DN STA-5312 DMGPIV0 MI TTYFKSZ DMGPIV0 MN Tubulin beta (TUBB) DMGPIV0 MT DTT DMGPIV0 MA Inhibitor DMGPIV0 RN Conjugated indole-imidazole derivatives displaying cytotoxicity against multidrug resistant cancer cell lines. Bioorganic & Medicinal Chemistry Letters. 11/2006; 16(19):5164-8. DMGPIV0 RU http://pubs.acs.org/doi/abs/10.1021/op6002852 DMDF29A DI DMDF29A DMDF29A DN STM 434 DMDF29A MI TT9RV4P DMDF29A MN Activin (ACT) DMDF29A MT DTT DMDF29A MA Inhibitor DMDF29A RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMDF29A RU http://phrma-docs.phrma.org/sites/default/files/pdf/medicines-in-development-drug-list-rare-diseases.pdf DMDF29A DI DMDF29A DMDF29A DN STM 434 DMDF29A MI TTMQO60 DMDF29A MN Rho-associated protein kinase (ROCK) DMDF29A MT DTT DMDF29A MA Inhibitor DMDF29A RN Rho kinase inhibitors: a patent review (2014 - 2016).Expert Opin Ther Pat. 2017 Apr;27(4):507-515. DMDF29A RU https://www.ncbi.nlm.nih.gov/pubmed/28048944 DMXCJP8 DI DMXCJP8 DMXCJP8 DN STP1002 DMXCJP8 MI TTKSAQZ DMXCJP8 MN Tankyrase (TNKS) DMXCJP8 MT DTT DMXCJP8 MA Inhibitor DMXCJP8 RN Design and development of a tankyrase inhibitor STP06-1002 as an anticancer therapeutic agent. Cancer Res 2017;77(13 Suppl):Abstract nr 5171. DMXCJP8 RU https://cancerres.aacrjournals.org/content/77/13_Supplement/5171 DMC5HXI DI DMC5HXI DMC5HXI DN STRO-002 DMC5HXI MI TTVC37M DMC5HXI MN Folate receptor alpha (FOLR1) DMC5HXI MT DTT DMC5HXI RN Clinical pipeline report, company report or official report of Sutro Biopharma. DMC5HXI RU https://www.sutrobio.com/pipeline/ DMJAPRK DI DMJAPRK DMJAPRK DN STX 64 DMJAPRK MI TTHM0R1 DMJAPRK MN Steryl-sulfatase (STS) DMJAPRK MT DTT DMJAPRK MA Inhibitor DMJAPRK RN Phase I study of STX 64 (667 Coumate) in breast cancer patients: the first study of a steroid sulfatase inhibitor. Clin Cancer Res. 2006 Mar 1;12(5):1585-92. DMJAPRK RU https://pubmed.ncbi.nlm.nih.gov/16533785 DMMAS3K DI DMMAS3K DMMAS3K DN SULFAMIDE DMMAS3K MI TTUNARX DMMAS3K MN Carbonic anhydrase (CA) DMMAS3K MT DTT DMMAS3K MA Inhibitor DMMAS3K RN Carbonic anhydrase inhibitors: crystallographic and solution binding studies for the interaction of a boron-containing aromatic sulfamide with mamm... Bioorg Med Chem Lett. 2010 Jun 15;20(12):3601-5. DMMAS3K RU https://pubmed.ncbi.nlm.nih.gov/20472429 DMMAS3K DI DMMAS3K DMMAS3K DN SULFAMIDE DMMAS3K MI TTHQPL7 DMMAS3K MN Carbonic anhydrase I (CA-I) DMMAS3K MT DTT DMMAS3K MA Inhibitor DMMAS3K RN Carbonic anhydrase inhibitors. Inhibition of the newly isolated murine isozyme XIII with anions. Bioorg Med Chem Lett. 2004 Nov 1;14(21):5435-9. DMMAS3K RU https://pubmed.ncbi.nlm.nih.gov/15454240 DMMAS3K DI DMMAS3K DMMAS3K DN SULFAMIDE DMMAS3K MI TTANPDJ DMMAS3K MN Carbonic anhydrase II (CA-II) DMMAS3K MT DTT DMMAS3K MA Inhibitor DMMAS3K RN Carbonic anhydrase inhibitors. Inhibition of the newly isolated murine isozyme XIII with anions. Bioorg Med Chem Lett. 2004 Nov 1;14(21):5435-9. DMMAS3K RU https://pubmed.ncbi.nlm.nih.gov/15454240 DMMAS3K DI DMMAS3K DMMAS3K DN SULFAMIDE DMMAS3K MI TTZHA0O DMMAS3K MN Carbonic anhydrase IV (CA-IV) DMMAS3K MT DTT DMMAS3K MA Inhibitor DMMAS3K RN Carbonic anhydrase inhibitors: crystallographic and solution binding studies for the interaction of a boron-containing aromatic sulfamide with mamm... Bioorg Med Chem Lett. 2010 Jun 15;20(12):3601-5. DMMAS3K RU https://pubmed.ncbi.nlm.nih.gov/20472429 DMMAS3K DI DMMAS3K DMMAS3K DN SULFAMIDE DMMAS3K MI TT2LVK8 DMMAS3K MN Carbonic anhydrase IX (CA-IX) DMMAS3K MT DTT DMMAS3K MA Inhibitor DMMAS3K RN Carbonic anhydrase inhibitors. Inhibition of isozymes I, II, IV, V, and IX with anions isosteric and isoelectronic with sulfate, nitrate, and carbo... Bioorg Med Chem Lett. 2005 Feb 1;15(3):567-71. DMMAS3K RU https://pubmed.ncbi.nlm.nih.gov/15664814 DMIF8RY DI DMIF8RY DMIF8RY DN SUN-K0706 DMIF8RY MI TT6PKBN DMIF8RY MN Proto-oncogene c-Src (SRC) DMIF8RY MT DTT DMIF8RY MA Inhibitor DMIF8RY RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMIF8RY RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DMDOSL0 DI DMDOSL0 DMDOSL0 DN SUN-N8075 DMDOSL0 MI TTC0BEN DMDOSL0 MN Oxidative stress (OS) DMDOSL0 MT DTT DMDOSL0 MA Inhibitor DMDOSL0 RN Protective effect of SUN N8075, a free radical scavenger, against excessive light-induced retinal damage in mice. Biol Pharm Bull. 2014;37(3):424-30. DMDOSL0 RU https://pubmed.ncbi.nlm.nih.gov/24583861 DMTOUY9 DI DMTOUY9 DMTOUY9 DN Suramin DMTOUY9 MI TTZFDBT DMTOUY9 MN Follicle-stimulating hormone receptor (FSHR) DMTOUY9 MT DTT DMTOUY9 MA Antagonist DMTOUY9 RN Suramin: clinical uses and structure-activity relationships. Mini Rev Med Chem. 2008 Nov;8(13):1384-94. DMTOUY9 RU https://pubmed.ncbi.nlm.nih.gov/18991754 DMTOUY9 DI DMTOUY9 DMTOUY9 DN Suramin DMTOUY9 MI TTR7GJO DMTOUY9 MN Heparanase (HPSE) DMTOUY9 MT DTT DMTOUY9 MA Inhibitor DMTOUY9 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1728). DMTOUY9 RU http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=1728 DMZP671 DI DMZP671 DMZP671 DN SUVN 911 DMZP671 MI TTL1ATN DMZP671 MN Neuronal acetylcholine receptor alpha-4/beta-2 (CHRNA4/B2) DMZP671 MT DTT DMZP671 MA Antagonist DMZP671 RN Discovery and Development of 3-(6-Chloropyridine-3-yloxymethyl)-2-azabicyclo[3.1.0]hexane Hydrochloride (SUVN-911): A Novel, Potent, Selective, and Orally Active Neuronal Nicotinic Acetylcholine alpha42 Receptor Antagonist for the Treatment of Depression. J Med Chem. 2020 Mar 26;63(6):2833-2853. DMZP671 RU https://pubmed.ncbi.nlm.nih.gov/32026697 DMLPBVF DI DMLPBVF DMLPBVF DN SUVN-911 DMLPBVF MI TT5KPZR DMLPBVF MN Neuronal acetylcholine receptor beta-2 (CHRNB2) DMLPBVF MT DTT DMLPBVF MA Antagonist DMLPBVF RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMLPBVF RU http://phrma-docs.phrma.org/files/dmfile/MID_Mental-Illness-2017-Drug-List_Final.pdf DM6ZOD2 DI DM6ZOD2 DM6ZOD2 DN SUVN-D4010 DM6ZOD2 MI TT07C3Y DM6ZOD2 MN 5-HT 4 receptor (HTR4) DM6ZOD2 MT DTT DM6ZOD2 MA Agonist DM6ZOD2 RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DM6ZOD2 RU http://phrma-docs.phrma.org/files/dmfile/MID_Neurological-Disorders-Drug-List_2018.pdf DMHMG6X DI DMHMG6X DMHMG6X DN SX-682 DMHMG6X MI TTMWT8Z DMHMG6X MN C-X-C chemokine receptor type 1 (CXCR1) DMHMG6X MT DTT DMHMG6X MA Inhibitor DMHMG6X RN Inhibition of MDSC Trafficking with SX-682, a CXCR1/2 Inhibitor, Enhances NK-Cell Immunotherapy in Head and Neck Cancer Models. Clin Cancer Res. 2020 Mar 15;26(6):1420-1431. DMHMG6X RU https://pubmed.ncbi.nlm.nih.gov/31848188 DMHMG6X DI DMHMG6X DMHMG6X DN SX-682 DMHMG6X MI TT30C9G DMHMG6X MN C-X-C chemokine receptor type 2 (CXCR2) DMHMG6X MT DTT DMHMG6X MA Inhibitor DMHMG6X RN Inhibition of MDSC Trafficking with SX-682, a CXCR1/2 Inhibitor, Enhances NK-Cell Immunotherapy in Head and Neck Cancer Models. Clin Cancer Res. 2020 Mar 15;26(6):1420-1431. DMHMG6X RU https://pubmed.ncbi.nlm.nih.gov/31848188 DMK48PM DI DMK48PM DMK48PM DN SY-1365 DMK48PM MI TTQYF7G DMK48PM MN Cyclin-dependent kinase 7 (CDK7) DMK48PM MT DTT DMK48PM MA Inhibitor DMK48PM RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMK48PM RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DMH8UF0 DI DMH8UF0 DMH8UF0 DN SY-1425 DMH8UF0 MI TTW38KT DMH8UF0 MN Retinoic acid receptor alpha (RARA) DMH8UF0 MT DTT DMH8UF0 MA Agonist DMH8UF0 RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMH8UF0 RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DMNW3LH DI DMNW3LH DMNW3LH DN SY-5609 DMNW3LH MI TTQYF7G DMNW3LH MN Cyclin-dependent kinase 7 (CDK7) DMNW3LH MT DTT DMNW3LH MA Inhibitor DMNW3LH RN Clinical pipeline report, company report or official report of Syros Pharmaceuticals. DMNW3LH RU https://www.syros.com/programs/sy-5609 DMVXLS5 DI DMVXLS5 DMVXLS5 DN Sym021 DMVXLS5 MI TTNBFWK DMVXLS5 MN Programmed cell death protein 1 (PD-1) DMVXLS5 MT DTT DMVXLS5 RN Development of Inhibitors of the Programmed Cell Death-1/Programmed Cell Death-Ligand 1 Signaling Pathway.J Med Chem. 2019 Feb 28;62(4):1715-1730. DMVXLS5 RU https://pubmed.ncbi.nlm.nih.gov/30247903 DMCK2YR DI DMCK2YR DMCK2YR DN Sym022 DMCK2YR MI TTNVXAW DMCK2YR MN Lymphocyte activation gene 3 protein (LAG3) DMCK2YR MT DTT DMCK2YR MA Inhibitor DMCK2YR RN Clinical pipeline report, company report or official report of Symphogen. DMCK2YR RU http://www.symphogen.com/pipeline/products/sym022/ DMV3L62 DI DMV3L62 DMV3L62 DN Sym023 DMV3L62 MI TT1RWL7 DMV3L62 MN Hepatitis A virus cellular receptor 2 (TIM3) DMV3L62 MT DTT DMV3L62 MA Inhibitor DMV3L62 RN Clinical pipeline report, company report or official report of Symphogen. DMV3L62 RU http://www.symphogen.com/pipeline/products/sym023/ DM0EZ69 DI DM0EZ69 DM0EZ69 DN SYN004 DM0EZ69 MI TTGKNB4 DM0EZ69 MN Epidermal growth factor receptor (EGFR) DM0EZ69 MT DTT DM0EZ69 MA Inhibitor DM0EZ69 RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DM0EZ69 RU http://phrma-docs.phrma.org/files/dmfile/MID_Immuno-Oncology-2017_Drug-List1.pdf DMX05W8 DI DMX05W8 DMX05W8 DN SYN-1001 DMX05W8 MI TTN4QDT DMX05W8 MN Opioid receptor (OPR) DMX05W8 MT DTT DMX05W8 MA Agonist DMX05W8 RN Improved brain uptake and pharmacological activity profile of morphine-6-glucuronide using a peptide vector-mediated strategy. J Pharmacol Exp Ther. 2005 May;313(2):712-9. DMX05W8 RU https://pubmed.ncbi.nlm.nih.gov/15647327 DM4UVTO DI DM4UVTO DM4UVTO DN SYN125 DM4UVTO MI TTNBFWK DM4UVTO MN Programmed cell death protein 1 (PD-1) DM4UVTO MT DTT DM4UVTO RN Clinical pipeline report, company report or official report of Symphogen. DM4UVTO RU https://www.synermore.com/pipeline DMZJNHM DI DMZJNHM DMZJNHM DN SYNB1891 DMZJNHM MI TTT402Y DMZJNHM MN Stimulator of interferon genes protein (TMEM173) DMZJNHM MT DTT DMZJNHM MA Agonist DMZJNHM RN Immunotherapy with engineered bacteria by targeting the STING pathway for anti-tumor immunity. Nat Commun. 2020 Jun 1;11(1):2739. DMZJNHM RU https://pubmed.ncbi.nlm.nih.gov/32483165 DM83E5B DI DM83E5B DM83E5B DN Synthetic neutrophil inhibitor peptide DM83E5B MI TTHQGFL DM83E5B MN PMN apoptosis and chemotaxis (PMNAC) DM83E5B MT DTT DM83E5B MA Inhibitor DM83E5B RN Attenuation of interleukin 8-induced nasal inflammation by an inhibitor peptide. Am J Respir Crit Care Med. 2001 Apr;163(5):1198-205. DM83E5B RU https://pubmed.ncbi.nlm.nih.gov/11316659 DMH76KD DI DMH76KD DMH76KD DN Syntropin DMH76KD MI TTKMAZ6 DMH76KD MN Growth hormone receptor (GHR) DMH76KD MT DTT DMH76KD MA Modulator DMH76KD RN Late feedback effects of hypothalamic-pituitary-adrenal axis hormones in healthy subjects. Psychoneuroendocrinology. 1998 May;23(4):371-83. DMH76KD RU https://pubmed.ncbi.nlm.nih.gov/9695137 DMD23AX DI DMD23AX DMD23AX DN Systebryl DMD23AX MI TTE4KHA DMD23AX MN Amyloid beta A4 protein (APP) DMD23AX MT DTT DMD23AX MA Inhibitor DMD23AX RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2402). DMD23AX RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2402 DMNE9Z0 DI DMNE9Z0 DMNE9Z0 DN T-0128 DMNE9Z0 MI TTUTN1I DMNE9Z0 MN Human Deoxyribonucleic acid (hDNA) DMNE9Z0 MT DTT DMNE9Z0 MA Inhibitor DMNE9Z0 RN Complete regression of xenografted human carcinomas by camptothecin analogue-carboxymethyl dextran conjugate (T-0128). Cancer Res. 2000 Jun 1;60(11):2988-95. DMNE9Z0 RU https://pubmed.ncbi.nlm.nih.gov/10850447 DMV8IQW DI DMV8IQW DMV8IQW DN Tafluposide DMV8IQW MI TTGTQHC DMV8IQW MN DNA topoisomerase I (TOP1) DMV8IQW MT DTT DMV8IQW MA Modulator DMV8IQW RN Ex vivo effects of the dual topoisomerase inhibitor tafluposide (F 11782) on cells isolated from fresh tumor samples taken from patients with cancer. Anticancer Drugs. 2003 Jul;14(6):467-73. DMV8IQW RU https://pubmed.ncbi.nlm.nih.gov/12853890 DMV8IQW DI DMV8IQW DMV8IQW DN Tafluposide DMV8IQW MI TT0IHXV DMV8IQW MN DNA topoisomerase II (TOP2) DMV8IQW MT DTT DMV8IQW MA Modulator DMV8IQW RN Ex vivo effects of the dual topoisomerase inhibitor tafluposide (F 11782) on cells isolated from fresh tumor samples taken from patients with cancer. Anticancer Drugs. 2003 Jul;14(6):467-73. DMV8IQW RU https://pubmed.ncbi.nlm.nih.gov/12853890 DM6OKH4 DI DM6OKH4 DM6OKH4 DN TAK-020 DM6OKH4 MI TTGM6VW DM6OKH4 MN Tyrosine-protein kinase BTK (ATK) DM6OKH4 MT DTT DM6OKH4 MA Inhibitor DM6OKH4 RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DM6OKH4 RU http://phrma-docs.phrma.org/files/dmfile/medicines-in-development-drug-list-autoimmune-diseases.pdf DM0ZQ7J DI DM0ZQ7J DM0ZQ7J DN TAK-041 DM0ZQ7J MI TTOL9B0 DM0ZQ7J MN G-protein-coupled receptor PGR3 (GPR139) DM0ZQ7J MT DTT DM0ZQ7J MA Agonist DM0ZQ7J RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DM0ZQ7J RU http://phrma-docs.phrma.org/files/dmfile/MID_Mental-Illness-2017-Drug-List_Final.pdf DMX9EA0 DI DMX9EA0 DMX9EA0 DN TAK-058 DMX9EA0 MI TTNXLKE DMX9EA0 MN 5-HT 3 receptor (5HT3R) DMX9EA0 MT DTT DMX9EA0 MA Antagonist DMX9EA0 RN Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800040805) DMX9EA0 RU http://adisinsight.springer.com/drugs/800040805 DMKUT08 DI DMKUT08 DMKUT08 DN TAK-071 DMKUT08 MI TTZ9SOR DMKUT08 MN Muscarinic acetylcholine receptor M1 (CHRM1) DMKUT08 MT DTT DMKUT08 MA Modulator DMKUT08 RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMKUT08 RU http://phrma-docs.phrma.org/files/dmfile/MID_Neurological-Disorders-Drug-List_2018.pdf DMD79TX DI DMD79TX DMD79TX DN TAK-102 DMD79TX MI TTJTSX4 DMD79TX MN Glypican-3 (GPC3) DMD79TX MT DTT DMD79TX RN ClinicalTrials.gov (NCT04405778) A Study of TAK-102 in Adult With Previously-Treated Solid Tumors. U.S. National Institutes of Health. DMD79TX RU https://clinicaltrials.gov/ct2/show/NCT04405778 DMTXE19 DI DMTXE19 DMTXE19 DN TAK-114 DMTXE19 MI TTH8FZW DMTXE19 MN Signal transducer and activator of transcription 3 (STAT3) DMTXE19 MT DTT DMTXE19 MA Modulator DMTXE19 RN Clinical pipeline report, company report or official report of Gastroenterology. DMTXE19 RU https://www.takeda.com/siteassets/system/investors/report/quarterlyannouncements/fy2014/takeda-ir-event--a-global-leader-in-gastroenterology-held-on-march-9-2015/qr2014_q3_p_en.pdf DMYG704 DI DMYG704 DMYG704 DN TAK-137 DMYG704 MI TTAN6JD DMYG704 MN Glutamate receptor AMPA (GRIA) DMYG704 MT DTT DMYG704 MA Modulator DMYG704 RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015 DMYG704 RU https://www.accessdata.fda.gov/scripts/cder/drugsatfda/ DMRINBJ DI DMRINBJ DMRINBJ DN TAK-169 DMRINBJ MI TTPURFN DMRINBJ MN Cyclic ADP-ribose hydrolase 1 (CD38) DMRINBJ MT DTT DMRINBJ MA Inhibitor DMRINBJ RN Clinical pipeline report, company report or official report of Molecular Templates. DMRINBJ RU https://www.mtem.com/pipeline/tak-169 DMVYEFZ DI DMVYEFZ DMVYEFZ DN TAK-202 DMVYEFZ MI TTFZYTO DMVYEFZ MN C-C chemokine receptor type 2 (CCR2) DMVYEFZ MT DTT DMVYEFZ MA Antagonist DMVYEFZ RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMVYEFZ RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DMW10HM DI DMW10HM DMW10HM DN Tak-220 DMW10HM MI TT2CEJG DMW10HM MN C-C chemokine receptor type 5 (CCR5) DMW10HM MT DTT DMW10HM MA Binder DMW10HM RN Progress in targeting HIV-1 entry. Drug Discov Today. 2005 Aug 15;10(16):1085-94. DMW10HM RU https://pubmed.ncbi.nlm.nih.gov/16182193 DM4GKV2 DI DM4GKV2 DM4GKV2 DN TAK-243 DM4GKV2 MI TTU8HT1 DM4GKV2 MN Ubiquitin-activating enzyme (UBA) DM4GKV2 MT DTT DM4GKV2 MA Inhibitor DM4GKV2 RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DM4GKV2 RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DM1AKNI DI DM1AKNI DM1AKNI DN TAK-252 DM1AKNI MI TTL31H0 DM1AKNI MN OX40L receptor (CD134) DM1AKNI MT DTT DM1AKNI MA Agonist DM1AKNI RN Clinical pipeline report, company report or official report of Shattuck Labs. DM1AKNI RU https://www.shattucklabs.com/pipeline/overview/ DM1AKNI DI DM1AKNI DM1AKNI DN TAK-252 DM1AKNI MI TT8ZLTI DM1AKNI MN Programmed cell death 1 ligand 1 (PD-L1) DM1AKNI MT DTT DM1AKNI MA Agonist DM1AKNI RN Clinical pipeline report, company report or official report of Shattuck Labs. DM1AKNI RU https://www.shattucklabs.com/pipeline/overview/ DM6KOBZ DI DM6KOBZ DM6KOBZ DN TAK-285 DM6KOBZ MI TT6EO5L DM6KOBZ MN Erbb2 tyrosine kinase receptor (HER2) DM6KOBZ MT DTT DM6KOBZ MA Inhibitor DM6KOBZ RN Clinical pipeline report, company report or official report of Takeda (2009). DM6KOBZ RU http://www.takeda.com/pdf/usr/default/10_1_34992_2.pdf DMMWNQP DI DMMWNQP DMMWNQP DN TAK-329 DMMWNQP MI TTDLNGZ DMMWNQP MN Glucokinase (GCK) DMMWNQP MT DTT DMMWNQP MA Inhibitor DMMWNQP RN Clinical pipeline report, company report or official report of Takeda. DMMWNQP RU https://www.takeda.com/csr/reports/pdf/index/ar2011_16_en.pdf DM7DFBL DI DM7DFBL DM7DFBL DN TAK-441 DM7DFBL MI TT8J1S3 DM7DFBL MN Smoothened homolog (SMO) DM7DFBL MT DTT DM7DFBL MA Modulator DM7DFBL RN TAK-441, a novel investigational smoothened antagonist, delays castration-resistant progression in prostate cancer by disrupting paracrine hedgehog signaling. Int J Cancer. 2013 Oct 15;133(8):1955-66. DM7DFBL RU https://pubmed.ncbi.nlm.nih.gov/23564295 DMUXAP1 DI DMUXAP1 DMUXAP1 DN TAK-573 DMUXAP1 MI TTPURFN DMUXAP1 MN Cyclic ADP-ribose hydrolase 1 (CD38) DMUXAP1 MT DTT DMUXAP1 RN Clinical pipeline report, company report or official report of Takeda. DMUXAP1 RU https://www.takeda.com/what-we-do/research-and-development/our-pipeline/ DMNFZOT DI DMNFZOT DMNFZOT DN TAK-593 DMNFZOT MI TTI7421 DMNFZOT MN Platelet-derived growth factor receptor beta (PDGFRB) DMNFZOT MT DTT DMNFZOT MA Modulator DMNFZOT RN Biochemical characterization of TAK-593, a novel VEGFR/PDGFR inhibitor with a two-step slow binding mechanism. Biochemistry. 2011 Feb 8;50(5):738-51. DMNFZOT RU https://www.ncbi.nlm.nih.gov/pubmed/21182308 DMNFZOT DI DMNFZOT DMNFZOT DN TAK-593 DMNFZOT MI TTUTJGQ DMNFZOT MN Vascular endothelial growth factor receptor 2 (KDR) DMNFZOT MT DTT DMNFZOT MA Modulator DMNFZOT RN Biochemical characterization of TAK-593, a novel VEGFR/PDGFR inhibitor with a two-step slow binding mechanism. Biochemistry. 2011 Feb 8;50(5):738-51. DMNFZOT RU https://www.ncbi.nlm.nih.gov/pubmed/21182308 DMQ8YKR DI DMQ8YKR DMQ8YKR DN TAK-648 DMQ8YKR MI TTV5CGO DMQ8YKR MN Phosphodiesterase 4 (PDE4) DMQ8YKR MT DTT DMQ8YKR MA Inhibitor DMQ8YKR RN Pharmacokinetic/Pharmacodynamic Modeling of the PDE4 Inhibitor TAK-648 in Type 2 Diabetes: Early Translational Approaches for Human Dose Prediction. Clin Transl Sci. 2017 May;10(3):185-193. DMQ8YKR RU https://pubmed.ncbi.nlm.nih.gov/28088839 DMCKF5J DI DMCKF5J DMCKF5J DN TAK-676 DMCKF5J MI TTT402Y DMCKF5J MN Stimulator of interferon genes protein (TMEM173) DMCKF5J MT DTT DMCKF5J MA Agonist DMCKF5J RN National Cancer Institute Drug Dictionary (drug name TAK676). DMCKF5J RU https://www.cancer.gov/publications/dictionaries/cancer-drug/def/sting-agonist-tak-676 DML3M0O DI DML3M0O DML3M0O DN TAK-701 DML3M0O MI TT4V2JM DML3M0O MN Hepatocyte growth factor (HGF) DML3M0O MT DTT DML3M0O MA Modulator DML3M0O RN Targeting MET in cancer: rationale and progress.Nat Rev Cancer.2012 Jan 24;12(2):89-103. DML3M0O RU https://www.ncbi.nlm.nih.gov/pubmed/22270953 DMC4RNA DI DMC4RNA DMC4RNA DN TAK-733 DMC4RNA MI TTROQ37 DMC4RNA MN MAPK/ERK kinase kinase (MAP3K) DMC4RNA MT DTT DMC4RNA MA Modulator DMC4RNA RN MEK and the inhibitors: from bench to bedside. J Hematol Oncol. 2013; 6: 27. DMC4RNA RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3626705/ DMW43DL DI DMW43DL DMW43DL DN TAK-828 DMW43DL MI TTGV6LY DMW43DL MN Nuclear receptor ROR-gamma (RORG) DMW43DL MT DTT DMW43DL MA Agonist DMW43DL RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMW43DL RU http://phrma-docs.phrma.org/files/dmfile/medicines-in-development-drug-list-autoimmune-diseases.pdf DM5KDGI DI DM5KDGI DM5KDGI DN TAK-901 DM5KDGI MI TT5LS6T DM5KDGI MN Aurora kinase B (AURKB) DM5KDGI MT DTT DM5KDGI MA Inhibitor DM5KDGI RN Clinical pipeline report, company report or official report of Takeda (2009). DM5KDGI RU http://www.takeda.com/pdf/usr/default/10_1_34992_2.pdf DM1ALY9 DI DM1ALY9 DM1ALY9 DN TAK-931 DM1ALY9 MI TTSMTDI DM1ALY9 MN CDC7-related kinase (CDC7) DM1ALY9 MT DTT DM1ALY9 MA Inhibitor DM1ALY9 RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DM1ALY9 RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DMN4OGH DI DMN4OGH DMN4OGH DN TAK-960 DMN4OGH MI TTIYVQP DMN4OGH MN Polo-like kinase 1 (PLK1) DMN4OGH MT DTT DMN4OGH MA Modulator DMN4OGH RN TAK-960, a novel, orally available, selective inhibitor of polo-like kinase 1, shows broad-spectrum preclinical antitumor activity in multiple dosing regimens. Mol Cancer Ther. 2012 Mar;11(3):700-9. DMN4OGH RU https://pubmed.ncbi.nlm.nih.gov/22188812 DMSQZEP DI DMSQZEP DMSQZEP DN TAR-200 DMSQZEP MI TTUBNVO DMSQZEP MN DNA synthesis (DNA synth) DMSQZEP MT DTT DMSQZEP MA Inhibitor DMSQZEP RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMSQZEP RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DM5WDKY DI DM5WDKY DM5WDKY DN TAS-103 DM5WDKY MI TT0IHXV DM5WDKY MN DNA topoisomerase II (TOP2) DM5WDKY MT DTT DM5WDKY MA Modulator DM5WDKY RN Mechanism of action of the dual topoisomerase-I and -II inhibitor TAS-103 and activity against (multi)drug resistant cells. Cancer Chemother Pharmacol. 2000;45(1):78-84. DM5WDKY RU https://www.ncbi.nlm.nih.gov/pubmed/10647506 DM5WDKY DI DM5WDKY DM5WDKY DN TAS-103 DM5WDKY MI DEYGVN4 DM5WDKY MN UDP-glucuronosyltransferase 1A1 (UGT1A1) DM5WDKY MT DME DM5WDKY MA Metabolism DM5WDKY RN Phase I clinical and pharmacogenetic study of weekly TAS-103 in patients with advanced cancer. J Clin Oncol. 2001 Apr 1;19(7):2084-90. DM5WDKY RU https://www.ncbi.nlm.nih.gov/pubmed/?term=11283142 DMRX530 DI DMRX530 DMRX530 DN TAS-116 DMRX530 MI TTH5YN2 DMRX530 MN Heat shock protein 90 beta (HSP90B) DMRX530 MT DTT DMRX530 MA Inhibitor DMRX530 RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMRX530 RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DMJXBVP DI DMJXBVP DMJXBVP DN TAS-119 DMJXBVP MI TTPS3C0 DMJXBVP MN Aurora kinase A (AURKA) DMJXBVP MT DTT DMJXBVP MA Inhibitor DMJXBVP RN TAS-119, a selective Aurora A inhibitor, enhanced the antitumor efficacy of taxanes in multiple human tumor cell lines including paclitaxel-resistant cells. Molecular Cancer Therapeutics. 01/2014; 12(11_Supplement):A268-A268. DMJXBVP RU http://mct.aacrjournals.org/content/12/11_Supplement/A268.short DMHIA7Y DI DMHIA7Y DMHIA7Y DN TAS-1440 DMHIA7Y MI TTNR0UQ DMHIA7Y MN Lysine-specific histone demethylase 1 (LSD) DMHIA7Y MT DTT DMHIA7Y MA Inhibitor DMHIA7Y RN Clinical pipeline report, company report or official report of Astex Pharmaceuticals. DMHIA7Y RU https://astx.com/tas1440-oral-lsd1-inhibitor-hematological-malignancies/ DMFG6ML DI DMFG6ML DMFG6ML DN TAS3681 DMFG6ML MI TTS64P2 DMFG6ML MN Androgen receptor (AR) DMFG6ML MT DTT DMFG6ML MA Antagonist DMFG6ML RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMFG6ML RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DMKW4AJ DI DMKW4AJ DMKW4AJ DN Tasidotin hydrochloride DMKW4AJ MI TTYFKSZ DMKW4AJ MN Tubulin beta (TUBB) DMKW4AJ MT DTT DMKW4AJ MA Binder DMKW4AJ RN Intracellular activation and deactivation of tasidotin, an analog of dolastatin 15: correlation with cytotoxicity. Mol Pharmacol. 2009 Jan;75(1):218-26. DMKW4AJ RU https://pubmed.ncbi.nlm.nih.gov/18927208 DM9CDPO DI DM9CDPO DM9CDPO DN TBC-M4 DM9CDPO MI TTEC2T3 DM9CDPO MN Human immunodeficiency virus Envelope glycoprotein gp160 (HIV env) DM9CDPO MT DTT DM9CDPO RN A Phase 1 study to evaluate the safety and immunogenicity of a recombinant HIV type 1 subtype C-modified vaccinia Ankara virus vaccine candidate in Indian volunteers. AIDS Res Hum Retroviruses. 2009 Nov;25(11):1107-16. DM9CDPO RU https://pubmed.ncbi.nlm.nih.gov/19943789 DM9CDPO DI DM9CDPO DM9CDPO DN TBC-M4 DM9CDPO MI TTFGZB6 DM9CDPO MN Human immunodeficiency virus GAG protein (HIV gag) DM9CDPO MT DTT DM9CDPO RN A Phase 1 study to evaluate the safety and immunogenicity of a recombinant HIV type 1 subtype C-modified vaccinia Ankara virus vaccine candidate in Indian volunteers. AIDS Res Hum Retroviruses. 2009 Nov;25(11):1107-16. DM9CDPO RU https://pubmed.ncbi.nlm.nih.gov/19943789 DM4W92J DI DM4W92J DM4W92J DN TC-2216 DM4W92J MI TTL1ATN DM4W92J MN Neuronal acetylcholine receptor alpha-4/beta-2 (CHRNA4/B2) DM4W92J MT DTT DM4W92J MA Modulator DM4W92J RN TC-5214 (S-(+)-mecamylamine): a neuronal nicotinic receptor modulator with antidepressant activity.CNS Neurosci Ther.2008 Winter;14(4):266-77. DM4W92J RU https://www.ncbi.nlm.nih.gov/pubmed/19040552 DMJEBK8 DI DMJEBK8 DMJEBK8 DN TCD-717 DMJEBK8 MI TT10AWB DMJEBK8 MN Choline kinase (CHKA) DMJEBK8 MT DTT DMJEBK8 MA Inhibitor DMJEBK8 RN National Cancer Institute Drug Dictionary (drug id 687183). DMJEBK8 RU http://www.cancer.gov/publications/dictionaries/cancer-drug?cdrid=687183 DMV0AH8 DI DMV0AH8 DMV0AH8 DN TCN-P DMV0AH8 MI TTAZ05C DMV0AH8 MN RAC-gamma serine/threonine-protein kinase (AKT3) DMV0AH8 MT DTT DMV0AH8 MA Modulator DMV0AH8 RN Phase I pharmacokinetic and pharmacodynamic study of triciribine phosphate monohydrate, a small-molecule inhibitor of AKT phosphorylation, in adult subjects with solid tumors containing activated AKT.Invest New Drugs.2011 Dec;29(6):1381-9. DMV0AH8 RU https://www.ncbi.nlm.nih.gov/pubmed/20644979 DMO8L6T DI DMO8L6T DMO8L6T DN TD-0714 DMO8L6T MI TT5TKPM DMO8L6T MN Neutral endopeptidase (MME) DMO8L6T MT DTT DMO8L6T MA Inhibitor DMO8L6T RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMO8L6T RU http://phrma-docs.phrma.org/files/dmfile/2018_Heart-Disease-and-Stroke_MID-Drug-List.pdf DMJG7AY DI DMJG7AY DMJG7AY DN TD-1473 DMJG7AY MI TTJSQEF DMJG7AY MN Tyrosine-protein kinase (PTK) DMJG7AY MT DTT DMJG7AY MA Inhibitor DMJG7AY RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMJG7AY RU http://phrma-docs.phrma.org/files/dmfile/medicines-in-development-drug-list-autoimmune-diseases.pdf DM58J7E DI DM58J7E DM58J7E DN Tedalinab DM58J7E MI TTMSFAW DM58J7E MN Cannabinoid receptor 2 (CB2) DM58J7E MT DTT DM58J7E MA Agonist DM58J7E RN Cannabinoid CB2 receptor (CNR2). SciBX 3(46); doi:10.1038/scibx.2010.1384. Dec. 2 2010 DM58J7E RU http://www.nature.com/scibx/journal/v3/n46/full/scibx.2010.1384.html DMV5LGJ DI DMV5LGJ DMV5LGJ DN Tedatioxetine DMV5LGJ MI TTWJBZ5 DMV5LGJ MN 5-HT 2C receptor (HTR2C) DMV5LGJ MT DTT DMV5LGJ MA Modulator DMV5LGJ RN Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41. DMV5LGJ RU https://www.ncbi.nlm.nih.gov/pubmed/15950434 DMV5LGJ DI DMV5LGJ DMV5LGJ DN Tedatioxetine DMV5LGJ MI TTNXLKE DMV5LGJ MN 5-HT 3 receptor (5HT3R) DMV5LGJ MT DTT DMV5LGJ MA Modulator DMV5LGJ RN Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41. DMV5LGJ RU https://www.ncbi.nlm.nih.gov/pubmed/15950434 DMZG9U0 DI DMZG9U0 DMZG9U0 DN TeloB-Vax DMZG9U0 MI TTUJFD0 DMZG9U0 MN Telomerase reverse transcriptase (TERT) DMZG9U0 MT DTT DMZG9U0 MA Modulator DMZG9U0 RN Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41. DMZG9U0 RU https://www.ncbi.nlm.nih.gov/pubmed/15950434 DM7Q4EX DI DM7Q4EX DM7Q4EX DN Temanogrel DM7Q4EX MI TTJQOD7 DM7Q4EX MN 5-HT 2A receptor (HTR2A) DM7Q4EX MT DTT DM7Q4EX MA Agonist DM7Q4EX RN Clinical pipeline report, company report or official report of Arena Pharmaceuticals. DM7Q4EX RU http://www.arenapharm.com/temanogrel DM4UOY5 DI DM4UOY5 DM4UOY5 DN TEN010 DM4UOY5 MI TTRA6BO DM4UOY5 MN Bromodomain-containing protein 4 (BRD4) DM4UOY5 MT DTT DM4UOY5 MA Modulator DM4UOY5 RN Targeting bromodomains: epigenetic readers of lysine acetylation.Nat Rev Drug Discov.2014 May;13(5):337-56. DM4UOY5 RU https://www.ncbi.nlm.nih.gov/pubmed/24751816 DMGJCDR DI DMGJCDR DMGJCDR DN Teneligliptin DMGJCDR MI DE4LYSA DMGJCDR MN Cytochrome P450 3A4 (CYP3A4) DMGJCDR MT DME DMGJCDR MA Metabolism DMGJCDR RN Effect of glimepiride on the pharmacokinetics of teneligliptin in healthy Korean subjects. J Clin Pharm Ther. 2019 Oct;44(5):720-725. DMGJCDR RU https://www.ncbi.nlm.nih.gov/pubmed/?term=31094010 DMGJCDR DI DMGJCDR DMGJCDR DN Teneligliptin DMGJCDR MI TTDIGC1 DMGJCDR MN Dipeptidyl peptidase 4 (DPP-4) DMGJCDR MT DTT DMGJCDR MA Modulator DMGJCDR RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1612). DMGJCDR RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1612 DMC84Y9 DI DMC84Y9 DMC84Y9 DN Tepoditamab DMC84Y9 MI TT70N8V DMC84Y9 MN Myeloid inhibitory C-type lectin-like receptor (CD371) DMC84Y9 MT DTT DMC84Y9 RN MCLA-117, a CLEC12AxCD3 bispecific antibody targeting a leukaemic stem cell antigen, induces T cell-mediated AML blast lysis. Expert Opin Biol Ther. 2019 Jul;19(7):721-733. DMC84Y9 RU https://pubmed.ncbi.nlm.nih.gov/31286786 DMC84Y9 DI DMC84Y9 DMC84Y9 DN Tepoditamab DMC84Y9 MI TTUN7MC DMC84Y9 MN T-cell surface glycoprotein CD3 (CD3) DMC84Y9 MT DTT DMC84Y9 RN MCLA-117, a CLEC12AxCD3 bispecific antibody targeting a leukaemic stem cell antigen, induces T cell-mediated AML blast lysis. Expert Opin Biol Ther. 2019 Jul;19(7):721-733. DMC84Y9 RU https://pubmed.ncbi.nlm.nih.gov/31286786 DM3DUHL DI DM3DUHL DM3DUHL DN TESTOSTERONE BUCICLATE DM3DUHL MI TTS64P2 DM3DUHL MN Androgen receptor (AR) DM3DUHL MT DTT DM3DUHL MA Agonist DM3DUHL RN Evidence for a role of testosterone-androgen receptor interactions in mediating masculine sexual behavior in male rats. Endocrinology. 1989 Feb;124(2):618-26. DM3DUHL RU https://pubmed.ncbi.nlm.nih.gov/2912689 DMAOJBX DI DMAOJBX DMAOJBX DN Tetrandrine DMAOJBX MI TT5HONZ DMAOJBX MN Calcium channel unspecific (CaC) DMAOJBX MT DTT DMAOJBX MA Antagonist DMAOJBX RN Tetrandrine: a novel calcium channel antagonist inhibits type I calcium channels in neuroblastoma cells. Neuropharmacology. 1991 Dec;30(12A):1325-31. DMAOJBX RU https://pubmed.ncbi.nlm.nih.gov/1787886 DMAOJBX DI DMAOJBX DMAOJBX DN Tetrandrine DMAOJBX MI DE4LYSA DMAOJBX MN Cytochrome P450 3A4 (CYP3A4) DMAOJBX MT DME DMAOJBX MA Metabolism DMAOJBX RN Integrated analysis on the physicochemical properties of dihydropyridine calcium channel blockers in grapefruit juice interactions. Curr Pharm Biotechnol. 2012 Jul;13(9):1705-17. DMAOJBX RU https://www.ncbi.nlm.nih.gov/pubmed/?term=22039822 DMAOJBX DI DMAOJBX DMAOJBX DN Tetrandrine DMAOJBX MI DEIBDNY DMAOJBX MN Cytochrome P450 3A5 (CYP3A5) DMAOJBX MT DME DMAOJBX MA Metabolism DMAOJBX RN CYP3A5 mediates bioactivation and cytotoxicity of tetrandrine. Arch Toxicol. 2016 Jul;90(7):1737-48. DMAOJBX RU https://www.ncbi.nlm.nih.gov/pubmed/?term=26302866 DMNDHKL DI DMNDHKL DMNDHKL DN TG-1701 DMNDHKL MI TTGM6VW DMNDHKL MN Tyrosine-protein kinase BTK (ATK) DMNDHKL MT DTT DMNDHKL MA Inhibitor DMNDHKL RN Clinical pipeline report, company report or official report of TG Therapeutics. DMNDHKL RU https://www.tgtherapeutics.com/our-pipeline/tg-1701/ DM3K4FY DI DM3K4FY DM3K4FY DN TG-1801 DM3K4FY MI TTW640A DM3K4FY MN B-lymphocyte surface antigen B4 (CD19) DM3K4FY MT DTT DM3K4FY RN Clinical pipeline report, company report or official report of TG Theraputics. DM3K4FY RU https://www.tgtherapeutics.com/our-pipeline/tg-1801/ DM3K4FY DI DM3K4FY DM3K4FY DN TG-1801 DM3K4FY MI TT28S46 DM3K4FY MN Leukocyte surface antigen CD47 (CD47) DM3K4FY MT DTT DM3K4FY RN Clinical pipeline report, company report or official report of TG Theraputics. DM3K4FY RU https://www.tgtherapeutics.com/our-pipeline/tg-1801/ DMWBQ2Z DI DMWBQ2Z DMWBQ2Z DN TGF-BR2 mab DMWBQ2Z MI TTZE3P7 DMWBQ2Z MN TGF-beta receptor type II (TGFBR2) DMWBQ2Z MT DTT DMWBQ2Z RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1795). DMWBQ2Z RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1795 DMC1HRA DI DMC1HRA DMC1HRA DN Thiarabine DMC1HRA MI TTUTN1I DMC1HRA MN Human Deoxyribonucleic acid (hDNA) DMC1HRA MT DTT DMC1HRA MA Inhibitor DMC1HRA RN Enzymology of Purine and Pyrimidine Antimetabolites Used in the Treatment of Cancer. Chem Rev. 2009 July; 109(7): 2880-2893. DMC1HRA RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2827868/ DMOLFAU DI DMOLFAU DMOLFAU DN Thiopilocarpine DMOLFAU MI TTZ9SOR DMOLFAU MN Muscarinic acetylcholine receptor M1 (CHRM1) DMOLFAU MT DTT DMOLFAU MA Agonist DMOLFAU RN SDZ ENS 163, a selective muscarinic M1 receptor agonist, facilitates the induction of long-term potentiation in rat hippocampal slices. Eur J Pharmacol. 1992 Nov 3;222(1):21-5. DMOLFAU RU https://pubmed.ncbi.nlm.nih.gov/1468496 DMHRY8A DI DMHRY8A DMHRY8A DN THR-687 DMHRY8A MI TTQFP08 DMHRY8A MN Integrin (ITG) DMHRY8A MT DTT DMHRY8A MA Antagonist DMHRY8A RN The potent small molecule integrin antagonist THR-687 is a promising next-generation therapy for retinal vascular disorders. Exp Eye Res. 2019 Mar;180:43-52. DMHRY8A RU https://pubmed.ncbi.nlm.nih.gov/30472075 DMO8SGD DI DMO8SGD DMO8SGD DN Thymidine kinase-expressing adenovirus and ganciclovir suicide gene therapy DMO8SGD MI TTP3QRF DMO8SGD MN Thymidine kinase 1 (TK1) DMO8SGD MT DTT DMO8SGD MA Modulator DMO8SGD RN Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41. DMO8SGD RU https://www.ncbi.nlm.nih.gov/pubmed/15950434 DMSVO92 DI DMSVO92 DMSVO92 DN Tigapotide DMSVO92 MI TTYH1ZK DMSVO92 MN Beta-microseminoprotein (MSMB) DMSVO92 MT DTT DMSVO92 MA Inhibitor DMSVO92 RN National Cancer Institute Drug Dictionary (drug id 600185). DMSVO92 RU http://www.cancer.gov/publications/dictionaries/cancer-drug?cdrid=600185 DMM3U2Q DI DMM3U2Q DMM3U2Q DN TJ4309 DMM3U2Q MI TTK0O6Y DMM3U2Q MN Ecto-5'-nucleotidase (CD73) DMM3U2Q MT DTT DMM3U2Q RN ClinicalTrials.gov (NCT04322006) A Phase I/II Study of TJ004309 for Advanced Solid Tumor. U.S. National Institutes of Health. DMM3U2Q RU https://clinicaltrials.gov/ct2/show/NCT04322006 DMLUOVS DI DMLUOVS DMLUOVS DN TJC4 DMLUOVS MI TT28S46 DMLUOVS MN Leukocyte surface antigen CD47 (CD47) DMLUOVS MT DTT DMLUOVS RN Clinical pipeline report, company report or official report of I-MAB Biopharma. DMLUOVS RU https://i-mabbiopharma.com/en/Pipeline.aspx DMTGLOY DI DMTGLOY DMTGLOY DN TK216 DMTGLOY MI TT9AH0M DMTGLOY MN Protein C-ets-2 (ETS2) DMTGLOY MT DTT DMTGLOY MA Inhibitor DMTGLOY RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMTGLOY RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DMCFGD4 DI DMCFGD4 DMCFGD4 DN TM38837 DMCFGD4 MI TT6OEDT DMCFGD4 MN Cannabinoid receptor 1 (CB1) DMCFGD4 MT DTT DMCFGD4 MA Antagonist DMCFGD4 RN 2011 Pipeline of 7TM Pharma. DMCFGD4 RU http://www.7tm.com/Pipeline.aspx DMH3E5C DI DMH3E5C DMH3E5C DN TMB-365 DMH3E5C MI TTN2JFW DMH3E5C MN T-cell surface glycoprotein CD4 (CD4) DMH3E5C MT DTT DMH3E5C RN Clinical pipeline report, company report or official report of TaiMed Biologics. DMH3E5C RU http://www.taimedbiologics.com/pipeline/36 DMYEALO DI DMYEALO DMYEALO DN TMC-647055 DMYEALO MI TTMVBWH DMYEALO MN Hepatitis C virus RNA-directed RNA polymerase (HCV NS5B) DMYEALO MT DTT DMYEALO MA Inhibitor DMYEALO RN WO patent application no. 2014,1522,75, Deuterium modified derivatives of the ns5b polymerase inhibitor tmc647055. DMYEALO RU http://worldwide.espacenet.com/publicationDetails/biblio?DB=worldwide.espacenet.com&II=0&ND=3&adjacent=true&locale=en_EP&FT=D&date=20140925&CC=WO&NR=2014152275A1&KC=A1 DMAOV7M DI DMAOV7M DMAOV7M DN TMC649128 DMAOV7M MI TTMVBWH DMAOV7M MN Hepatitis C virus RNA-directed RNA polymerase (HCV NS5B) DMAOV7M MT DTT DMAOV7M MA Inhibitor DMAOV7M RN Clinical pipeline report, company report or official report of Medivir (2011). DMAOV7M RU http://www.medivir.se/v4/en/ DMAI0SH DI DMAI0SH DMAI0SH DN TNB-383B DMAI0SH MI TTZ3P4W DMAI0SH MN B-cell maturation protein (TNFRSF17) DMAI0SH MT DTT DMAI0SH RN Clinical pipeline report, company report or official report of AbbVie. DMAI0SH RU https://www.abbvie.com/our-science/pipeline/tnb-383b.html DMAI0SH DI DMAI0SH DMAI0SH DN TNB-383B DMAI0SH MI TTUN7MC DMAI0SH MN T-cell surface glycoprotein CD3 (CD3) DMAI0SH MT DTT DMAI0SH RN Clinical pipeline report, company report or official report of AbbVie. DMAI0SH RU https://www.abbvie.com/our-science/pipeline/tnb-383b.html DMSRICG DI DMSRICG DMSRICG DN TNB-486 DMSRICG MI TTW640A DMSRICG MN B-lymphocyte surface antigen B4 (CD19) DMSRICG MT DTT DMSRICG RN Clinical pipeline report, company report or official report of Teneobio. DMSRICG RU https://teneobio.com/our-pipeline/ DMSRICG DI DMSRICG DMSRICG DN TNB-486 DMSRICG MI TTUN7MC DMSRICG MN T-cell surface glycoprotein CD3 (CD3) DMSRICG MT DTT DMSRICG RN Clinical pipeline report, company report or official report of Teneobio. DMSRICG RU https://teneobio.com/our-pipeline/ DMHD6PA DI DMHD6PA DMHD6PA DN TnMUC-1 CAR-T cell therapy DMHD6PA MI TTBHFYQ DMHD6PA MN Mucin-1 (MUC1) DMHD6PA MT DTT DMHD6PA MA Inhibitor DMHD6PA RN ClinicalTrials.gov (NCT04025216) A Study of CART-TnMUC1 in Patients With TnMUC1-Positive Advanced Cancers. U.S. National Institutes of Health. DMHD6PA RU https://clinicaltrials.gov/ct2/show/NCT04025216 DMZ60X4 DI DMZ60X4 DMZ60X4 DN TNO155 DMZ60X4 MI TT7WUAV DMZ60X4 MN Protein-tyrosine phosphatase SHP-2 (PTPN11) DMZ60X4 MT DTT DMZ60X4 MA Inhibitor DMZ60X4 RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMZ60X4 RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DMSKF29 DI DMSKF29 DMSKF29 DN TNT009 DMSKF29 MI TT7LRQH DMSKF29 MN Complement C1s component (C1S) DMSKF29 MT DTT DMSKF29 MA Inhibitor DMSKF29 RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMSKF29 RU http://phrma-docs.phrma.org/files/dmfile/medicines-in-development-drug-list-autoimmune-diseases.pdf DMD0NA1 DI DMD0NA1 DMD0NA1 DN TP 6076 DMD0NA1 MI TTOVFH2 DMD0NA1 MN Bacterial 30S ribosomal RNA (Bact 30S rRNA) DMD0NA1 MT DTT DMD0NA1 MA Inhibitor DMD0NA1 RN Clinical pipeline report, company report or official report of Tetraphase Pharmaceuticals. DMD0NA1 RU https://www.tphase.com/wp-content/uploads/2019/04/IDWeek-2018-TP-6076-Pipeline-FINAL-website.pdf DMJVZBC DI DMJVZBC DMJVZBC DN TP-0184 DMJVZBC MI TTJNBQA DMJVZBC MN Activin receptor-like kinase 2 (ALK-2) DMJVZBC MT DTT DMJVZBC MA Inhibitor DMJVZBC RN Clinical pipeline report, company report or official report of Sumitomo Dainippon Pharma. DMJVZBC RU https://www.sdponcology.com/pipeline/ DMJVZBC DI DMJVZBC DMJVZBC DN TP-0184 DMJVZBC MI TTP4520 DMJVZBC MN TGF-beta receptor type I (TGFBR1) DMJVZBC MT DTT DMJVZBC MA Inhibitor DMJVZBC RN Clinical pipeline report, company report or official report of Sumitomo Dainippon Pharma. DMJVZBC RU https://www.sdponcology.com/pipeline/ DM3Z07E DI DM3Z07E DM3Z07E DN TP-1287 DM3Z07E MI TT1LVF2 DM3Z07E MN Cyclin-dependent kinase 9 (CDK9) DM3Z07E MT DTT DM3Z07E MA Inhibitor DM3Z07E RN Clinical pipeline report, company report or official report of Sumitomo Dainippon Pharma. DM3Z07E RU https://www.sdponcology.com/pipeline/ DMBTL2M DI DMBTL2M DMBTL2M DN TP-1454 DMBTL2M MI TT4LOT8 DMBTL2M MN Pyruvate kinase M2 (PKM) DMBTL2M MT DTT DMBTL2M MA Activator DMBTL2M RN Clinical pipeline report, company report or official report of Sumitomo Dainippon Pharma. DMBTL2M RU https://www.ds-pharma.com/rd/clinical/pipeline.html DM3PJSE DI DM3PJSE DM3PJSE DN TP-271 DM3PJSE MI TTOVFH2 DM3PJSE MN Bacterial 30S ribosomal RNA (Bact 30S rRNA) DM3PJSE MT DTT DM3PJSE MA Inhibitor DM3PJSE RN Clinical pipeline report, company report or official report of Tetraphase Pharmaceuticals. DM3PJSE RU https://www.tphase.com/products/pipeline/ DMBQ6XY DI DMBQ6XY DMBQ6XY DN TP-3654 DMBQ6XY MI TTA7WGU DMBQ6XY MN Serine/threonine-protein kinase pim (PIM) DMBQ6XY MT DTT DMBQ6XY MA Inhibitor DMBQ6XY RN Clinical pipeline report, company report or official report of Sumitomo Dainippon Pharma. DMBQ6XY RU https://www.sdponcology.com/pipeline/ DM5RIT8 DI DM5RIT8 DM5RIT8 DN TP-6076 DM5RIT8 MI TTOVFH2 DM5RIT8 MN Bacterial 30S ribosomal RNA (Bact 30S rRNA) DM5RIT8 MT DTT DM5RIT8 RN Clinical pipeline report, company report or official report of Tetraphase Pharmaceuticals. DM5RIT8 RU https://www.tphase.com/wp-content/uploads/2019/04/IDWeek-2018-TP-6076-Pipeline-FINAL-website.pdf DMG4U32 DI DMG4U32 DMG4U32 DN TPST-1120 DMG4U32 MI TTJ584C DMG4U32 MN Peroxisome proliferator-activated receptor alpha (PPARA) DMG4U32 MT DTT DMG4U32 MA Antagonist DMG4U32 RN Clinical pipeline report, company report or official report of Tempest Therapeutics. DMG4U32 RU https://www.tempesttx.com/pipeline/ DM3GSB2 DI DM3GSB2 DM3GSB2 DN TPST-1495 DM3GSB2 MI TT1ZAVI DM3GSB2 MN Prostaglandin E2 receptor EP2 (PTGER2) DM3GSB2 MT DTT DM3GSB2 MA Antagonist DM3GSB2 RN Clinical pipeline report, company report or official report of Tempest Therapeutics. DM3GSB2 RU https://www.tempesttx.com/pipeline/ DM3GSB2 DI DM3GSB2 DM3GSB2 DN TPST-1495 DM3GSB2 MI TT79WV3 DM3GSB2 MN Prostaglandin E2 receptor EP4 (PTGER4) DM3GSB2 MT DTT DM3GSB2 MA Antagonist DM3GSB2 RN Clinical pipeline report, company report or official report of Tempest Therapeutics. DM3GSB2 RU https://www.tempesttx.com/pipeline/ DMC2IJN DI DMC2IJN DMC2IJN DN TPX-0022 DMC2IJN MI TT7MRDV DMC2IJN MN Macrophage colony-stimulating factor 1 receptor (CSF1R) DMC2IJN MT DTT DMC2IJN MA Inhibitor DMC2IJN RN Clinical pipeline report, company report or official report of Turning Point Therapeutics. DMC2IJN RU https://tptherapeutics.com/pipeline/tpx-0022/ DMC2IJN DI DMC2IJN DMC2IJN DN TPX-0022 DMC2IJN MI TTNDSF4 DMC2IJN MN Proto-oncogene c-Met (MET) DMC2IJN MT DTT DMC2IJN MA Inhibitor DMC2IJN RN Clinical pipeline report, company report or official report of Turning Point Therapeutics. DMC2IJN RU https://tptherapeutics.com/pipeline/tpx-0022/ DMC2IJN DI DMC2IJN DMC2IJN DN TPX-0022 DMC2IJN MI TT6PKBN DMC2IJN MN Proto-oncogene c-Src (SRC) DMC2IJN MT DTT DMC2IJN MA Inhibitor DMC2IJN RN Clinical pipeline report, company report or official report of Turning Point Therapeutics. DMC2IJN RU https://tptherapeutics.com/pipeline/tpx-0022/ DMGC2AT DI DMGC2AT DMGC2AT DN TR1801-ADC DMGC2AT MI TTNDSF4 DMGC2AT MN Proto-oncogene c-Met (MET) DMGC2AT MT DTT DMGC2AT RN TR1801-ADC: a highly potent cMet antibody-drug conjugate with high activity in patient-derived xenograft models of solid tumors. Mol Oncol. 2020 Jan;14(1):54-68. DMGC2AT RU https://pubmed.ncbi.nlm.nih.gov/31736230 DMMRDUN DI DMMRDUN DMMRDUN DN TrasGEX DMMRDUN MI TT6EO5L DMMRDUN MN Erbb2 tyrosine kinase receptor (HER2) DMMRDUN MT DTT DMMRDUN RN J Clin Oncol 32:5s, 2014 (suppl; abstr 2515). DMMRDUN RU http://meetinglibrary.asco.org/content/131582-144 DM1DIVY DI DM1DIVY DM1DIVY DN TRemelimumab + MEDI0562 DM1DIVY MI TTI2S1D DM1DIVY MN Cytotoxic T-lymphocyte protein 4 (CTLA-4) DM1DIVY MT DTT DM1DIVY MA Agonist DM1DIVY RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DM1DIVY RU http://phrma-docs.phrma.org/files/dmfile/MID_Immuno-Oncology-2017_Drug-List1.pdf DM1DIVY DI DM1DIVY DM1DIVY DN TRemelimumab + MEDI0562 DM1DIVY MI TTL31H0 DM1DIVY MN OX40L receptor (CD134) DM1DIVY MT DTT DM1DIVY MA Agonist DM1DIVY RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DM1DIVY RU http://phrma-docs.phrma.org/files/dmfile/MID_Immuno-Oncology-2017_Drug-List1.pdf DMQ7UN6 DI DMQ7UN6 DMQ7UN6 DN Trodusquemine DMQ7UN6 MI TTMS7KP DMQ7UN6 MN Protein-tyrosine phosphatase 1B (PTP1B) DMQ7UN6 MT DTT DMQ7UN6 MA Inhibitor DMQ7UN6 RN Inhibition of PTP1B by trodusquemine (MSI-1436) causes fat-specific weight loss in diet-induced obese mice. Obesity (Silver Spring). 2010 Aug;18(8):1516-23. DMQ7UN6 RU https://pubmed.ncbi.nlm.nih.gov/20075852 DMDSF0Q DI DMDSF0Q DMDSF0Q DN TROVIRDINE HYDROCHLORIDE DMDSF0Q MI TT84ETX DMDSF0Q MN Human immunodeficiency virus Reverse transcriptase (HIV RT) DMDSF0Q MT DTT DMDSF0Q MA Modulator DMDSF0Q RN Inhibition of human immunodeficiency virus type 1 wild-type and mutant reverse transcriptases by the phenyl ethyl thiazolyl thiourea derivatives tr... Antiviral Res. 1995 Dec;28(4):331-42. DMDSF0Q RU https://www.ncbi.nlm.nih.gov/pubmed/8669892 DMSLQW2 DI DMSLQW2 DMSLQW2 DN TRPH-222 DMSLQW2 MI TTM6QSK DMSLQW2 MN B-cell receptor CD22 (CD22) DMSLQW2 MT DTT DMSLQW2 RN Clinical pipeline report, company report or official report of Triphase Accelerator. DMSLQW2 RU http://triphaseco.com/trph-222/ DM2WZ86 DI DM2WZ86 DM2WZ86 DN TRV250 DM2WZ86 MI TT27RFC DM2WZ86 MN Opioid receptor delta (OPRD1) DM2WZ86 MT DTT DM2WZ86 MA Modulator DM2WZ86 RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DM2WZ86 RU http://phrma-docs.phrma.org/files/dmfile/MID_Neurological-Disorders-Drug-List_2018.pdf DMHD8CF DI DMHD8CF DMHD8CF DN TRV734 DMHD8CF MI TTKWM86 DMHD8CF MN Opioid receptor mu (MOP) DMHD8CF MT DTT DMHD8CF MA Agonist DMHD8CF RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMHD8CF RU http://phrma-docs.phrma.org/files/dmfile/MID_Neurological-Disorders-Drug-List_2018.pdf DM9IDUH DI DM9IDUH DM9IDUH DN TRX518 DM9IDUH MI TTG6LA7 DM9IDUH MN Activation-inducible TNFR family receptor (TNFRSF18) DM9IDUH MT DTT DM9IDUH RN Clinical pipeline report, company report or official report of Leap Therapeutics. DM9IDUH RU https://www.leaptx.com/our-pipeline DMVGN42 DI DMVGN42 DMVGN42 DN TRX-818 DMVGN42 MI TTB8Y9K DMVGN42 MN Angiogenesis (AGG) DMVGN42 MT DTT DMVGN42 MA Inhibitor DMVGN42 RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMVGN42 RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DMNTVUK DI DMNTVUK DMNTVUK DN TS01 DMNTVUK MI TT7LRQH DMNTVUK MN Complement C1s component (C1S) DMNTVUK MT DTT DMNTVUK MA Modulator DMNTVUK RN Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41. DMNTVUK RU https://www.ncbi.nlm.nih.gov/pubmed/15950434 DM56PFL DI DM56PFL DM56PFL DN TSR-042 DM56PFL MI TTNBFWK DM56PFL MN Programmed cell death protein 1 (PD-1) DM56PFL MT DTT DM56PFL RN Development of Inhibitors of the Programmed Cell Death-1/Programmed Cell Death-Ligand 1 Signaling Pathway.J Med Chem. 2019 Feb 28;62(4):1715-1730. DM56PFL RU https://pubmed.ncbi.nlm.nih.gov/30247903 DMZ9EMO DI DMZ9EMO DMZ9EMO DN TST001 DMZ9EMO MI TT6PKBX DMZ9EMO MN Claudin-18 (CLDN18) DMZ9EMO MT DTT DMZ9EMO RN Clinical pipeline report, company report or official report of Transcenta. DMZ9EMO RU http://www.transcenta.com/pipeline DMT5AEF DI DMT5AEF DMT5AEF DN TST-10088 DMT5AEF MI TTJ073B DMT5AEF MN Ribosome (hRBS) DMT5AEF MT DTT DMT5AEF MA Immunomodulator (Immunostimulant) DMT5AEF RN Gateways to clinical trials. Methods Find Exp Clin Pharmacol. 2009 Nov;31(9):597-633. DMT5AEF RU https://pubmed.ncbi.nlm.nih.gov/20094643 DMLDSX8 DI DMLDSX8 DMLDSX8 DN TT-30 DMLDSX8 MI TTUW6OP DMLDSX8 MN Complement factor H (CFH) DMLDSX8 MT DTT DMLDSX8 MA Modulator DMLDSX8 RN The complement receptor 2/factor H fusion protein TT30 protects paroxysmal nocturnal hemoglobinuria erythrocytes from complement-mediated hemolysis and C3 fragment. Blood. 2012 Jun 28;119(26):6307-16. DMLDSX8 RU https://pubmed.ncbi.nlm.nih.gov/22577173 DMLDSX8 DI DMLDSX8 DMLDSX8 DN TT-30 DMLDSX8 MI TT0HUN7 DMLDSX8 MN Complement receptor type 2 (CD21) DMLDSX8 MT DTT DMLDSX8 MA Modulator DMLDSX8 RN The complement receptor 2/factor H fusion protein TT30 protects paroxysmal nocturnal hemoglobinuria erythrocytes from complement-mediated hemolysis and C3 fragment. Blood. 2012 Jun 28;119(26):6307-16. DMLDSX8 RU https://pubmed.ncbi.nlm.nih.gov/22577173 DM4QV8Y DI DM4QV8Y DM4QV8Y DN TT-301 DM4QV8Y MI TTRYK0X DM4QV8Y MN Interleukin-1 beta (IL1B) DM4QV8Y MT DTT DM4QV8Y MA Inhibitor DM4QV8Y RN A Swell in the Armamentarium of Antiepileptic Drug Targets. Epilepsy Curr. 2011 Nov-Dec; 11(6): 172-176. DM4QV8Y RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3220427/ DM7CHZ2 DI DM7CHZ2 DM7CHZ2 DN TTC-352 DM7CHZ2 MI TTZAYWL DM7CHZ2 MN Estrogen receptor (ESR) DM7CHZ2 MT DTT DM7CHZ2 MA Agonist DM7CHZ2 RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DM7CHZ2 RU http://phrma-docs.phrma.org/files/dmfile/2018-Cancer-Drug-List.pdf DM7E6V2 DI DM7E6V2 DM7E6V2 DN TTC-352 DM7E6V2 MI TTZAYWL DM7E6V2 MN Estrogen receptor (ESR) DM7E6V2 MT DTT DM7E6V2 MA Agonist DM7E6V2 RN Clinical pipeline report, company report or official report of TTC Oncology. DM7E6V2 RU https://ttconcology.com/our-product/ DMDNPAV DI DMDNPAV DMDNPAV DN TTI-621 DMDNPAV MI TT28S46 DMDNPAV MN Leukocyte surface antigen CD47 (CD47) DMDNPAV MT DTT DMDNPAV MA Inhibitor DMDNPAV RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMDNPAV RU http://phrma-docs.phrma.org/files/dmfile/MID_Skin_Diseases_2018_9_FINAL.pdf DMOCQ4K DI DMOCQ4K DMOCQ4K DN TTI-622 DMOCQ4K MI TT28S46 DMOCQ4K MN Leukocyte surface antigen CD47 (CD47) DMOCQ4K MT DTT DMOCQ4K MA Blocker DMOCQ4K RN Clinical pipeline report, company report or official report of Trillium Therapeutics. DMOCQ4K RU https://trilliumtherapeutics.com/pipeline/ DMCG01R DI DMCG01R DMCG01R DN TTP-4000 DMCG01R MI TTMO9HF DMCG01R MN Advanced glycosylation end product receptor (AGER) DMCG01R MT DTT DMCG01R MA Inhibitor DMCG01R RN Receptor for advanced glycation end products: its role in Alzheimer's disease and other neurological diseases. Future Neurol. 2009; 4(2): 167-177. DMCG01R RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2709862/ DMYFUOP DI DMYFUOP DMYFUOP DN TTP-547 DMYFUOP MI TTDLNGZ DMYFUOP MN Glucokinase (GCK) DMYFUOP MT DTT DMYFUOP MA Activator DMYFUOP RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2798). DMYFUOP RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2798 DM8H2AG DI DM8H2AG DM8H2AG DN TTX-030 DM8H2AG MI TTYM8DJ DM8H2AG MN Ectonucleoside triphosphate diphosphohydrolase 1 (CD39) DM8H2AG MT DTT DM8H2AG MA Inhibitor DM8H2AG RN Clinical pipeline report, company report or official report of AbbVie. DM8H2AG RU https://www.abbvie.com/our-science/pipeline/ttx-030.html DM6GKYF DI DM6GKYF DM6GKYF DN TTX-080 DM6GKYF MI TTLKFB3 DM6GKYF MN MHC class I antigen G (HLA-G) DM6GKYF MT DTT DM6GKYF MA Inhibitor DM6GKYF RN Clinical pipeline report, company report or official report of Tizona Therapeutics. DM6GKYF RU https://www.tizonatx.com/science/ DM36ONA DI DM36ONA DM36ONA DN Turofexorate isopropyl DM36ONA MI TTS4UGC DM36ONA MN Farnesoid X-activated receptor (FXR) DM36ONA MT DTT DM36ONA MA Modulator DM36ONA RN A synthetic farnesoid X receptor (FXR) agonist promotes cholesterol lowering in models of dyslipidemia. Am J Physiol Gastrointest Liver Physiol. 2009 Mar;296(3):G543-52. DM36ONA RU https://pubmed.ncbi.nlm.nih.gov/19136377 DMZIK8R DI DMZIK8R DMZIK8R DN TXA709 DMZIK8R MI TT4W1VJ DMZIK8R MN Bacterial Celldivision protein FtsZ (Bact ftsZ) DMZIK8R MT DTT DMZIK8R MA Inhibitor DMZIK8R RN Clinical pipeline report, company report or official report of TAXIS Pharmaceuticals. DMZIK8R RU https://www.taxispharma.com/research-development/our-pipeline/ DMWOE62 DI DMWOE62 DMWOE62 DN U3-1565 DMWOE62 MI TT15SL0 DMWOE62 MN Proheparin-binding EGF-like growth factor (HBEGF) DMWOE62 MT DTT DMWOE62 MA Modulator DMWOE62 RN J Clin Oncol 31, 2013 (suppl; abstr 2519). DMWOE62 RU http://meetinglibrary.asco.org/content/111447-132 DM5XMHB DI DM5XMHB DM5XMHB DN UC-781 DM5XMHB MI TT84ETX DM5XMHB MN Human immunodeficiency virus Reverse transcriptase (HIV RT) DM5XMHB MT DTT DM5XMHB MA Inhibitor DM5XMHB RN The nonnucleoside reverse transcriptase inhibitor UC-781 inhibits human immunodeficiency virus type 1 infection of human cervical tissue and dissemination by migratory cells. J Virol. 2005 Sep;79(17):11179-86. DM5XMHB RU https://pubmed.ncbi.nlm.nih.gov/16103169 DMG7FLI DI DMG7FLI DMG7FLI DN UCART123 DMG7FLI MI TTENHJ0 DMG7FLI MN Interleukin 3 receptor alpha (IL3RA) DMG7FLI MT DTT DMG7FLI MA CAR-T-Cell-Therapy DMG7FLI RN ClinicalTrials.gov (NCT03190278) Study Evaluating Safety and Efficacy of UCART123 in Patients With Acute Myeloid Leukemia DMG7FLI RU https://clinicaltrials.gov/ct2/show/NCT03190278 DMARHU4 DI DMARHU4 DMARHU4 DN UCART-22 DMARHU4 MI TTM6QSK DMARHU4 MN B-cell receptor CD22 (CD22) DMARHU4 MT DTT DMARHU4 RN Clinical pipeline report, company report or official report of Cellectis. DMARHU4 RU https://www.cellectis.com/en/products/product-candidates/ DM2Y4D7 DI DM2Y4D7 DM2Y4D7 DN UCARTCS1 DM2Y4D7 MI TT7ILZ1 DM2Y4D7 MN SLAM family member 7 SLAMF7 (CS1) DM2Y4D7 MT DTT DM2Y4D7 RN ClinicalTrials.gov (NCT04142619) Study Evaluating Safety and Efficacy of UCART Targeting CS1 in Patients With Relapsed/Refractory Multiple Myeloma (MELANI-01). U.S. National Institutes of Health. DM2Y4D7 RU https://clinicaltrials.gov/ct2/show/NCT04142619 DMSCXB7 DI DMSCXB7 DMSCXB7 DN UK-240455 DMSCXB7 MI TTZ8EM9 DMSCXB7 MN Glycine receptor (GlyR) DMSCXB7 MT DTT DMSCXB7 MA Modulator DMSCXB7 RN UK-315716/UK-240455. Pfizer. Curr Opin Investig Drugs. 2001 Dec;2(12):1737-9. DMSCXB7 RU https://pubmed.ncbi.nlm.nih.gov/11892937 DMI8795 DI DMI8795 DMI8795 DN UK-371800 DMI8795 MI TTJ0IQB DMI8795 MN Phosphodiesterase 5A (PDE5A) DMI8795 MT DTT DMI8795 MA Inhibitor DMI8795 RN Highly potent and selective chiral inhibitors of PDE5: an illustration of Pfeiffer's rule. Bioorg Med Chem Lett. 2008 Dec 1;18(23):6033-6. DMI8795 RU https://pubmed.ncbi.nlm.nih.gov/18951784 DMFYKDX DI DMFYKDX DMFYKDX DN UK-396082 DMFYKDX MI TTP18AY DMFYKDX MN Carboxypeptidase B2 (CPB2) DMFYKDX MT DTT DMFYKDX MA Inhibitor DMFYKDX RN Oxygenated analogues of UK-396082 as inhibitors of activated thrombin activatable fibrinolysis inhibitor. Bioorg Med Chem Lett. 2010 Jan 1;20(1):92-6. DMFYKDX RU https://pubmed.ncbi.nlm.nih.gov/19954973 DMO8Z1D DI DMO8Z1D DMO8Z1D DN UK-66914 DMO8Z1D MI TT1VOHK DMO8Z1D MN Potassium channel unspecific (KC) DMO8Z1D MT DTT DMO8Z1D MA Blocker DMO8Z1D RN Electrophysiologic properties of UK-66,914, a novel class III antiarrhythmic agent. J Cardiovasc Pharmacol. 1991 Mar;17(3):376-85. DMO8Z1D RU https://pubmed.ncbi.nlm.nih.gov/1711597 DMHG7DZ DI DMHG7DZ DMHG7DZ DN UltraCD40L DMHG7DZ MI TTIJP3Q DMHG7DZ MN TNF related activation protein (CD40LG) DMHG7DZ MT DTT DMHG7DZ MA Modulator DMHG7DZ RN CD40L-Tri, a novel formulation of recombinant human CD40L that effectively activates B cells. Cancer Immunol Immunother. 2013 February; 62(2): 347-357. DMHG7DZ RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3569584/ DMTLNGV DI DMTLNGV DMTLNGV DN Umespirone DMTLNGV MI TTSQIFT DMTLNGV MN 5-HT 1A receptor (HTR1A) DMTLNGV MT DTT DMTLNGV MA Antagonist DMTLNGV RN The effects of umespirone as a potential anxiolytic and antipsychotic agent. Pharmacol Biochem Behav. 1991 Sep;40(1):89-96. DMTLNGV RU https://pubmed.ncbi.nlm.nih.gov/1685786 DMTLNGV DI DMTLNGV DMTLNGV DN Umespirone DMTLNGV MI TTEX248 DMTLNGV MN Dopamine D2 receptor (D2R) DMTLNGV MT DTT DMTLNGV MA Antagonist DMTLNGV RN The effects of umespirone as a potential anxiolytic and antipsychotic agent. Pharmacol Biochem Behav. 1991 Sep;40(1):89-96. DMTLNGV RU https://pubmed.ncbi.nlm.nih.gov/1685786 DMI5UEB DI DMI5UEB DMI5UEB DN Unacylated ghrelin DMI5UEB MI TT1OCL0 DMI5UEB MN Ghrelin (GHRL) DMI5UEB MT DTT DMI5UEB MA Inhibitor DMI5UEB RN Alize Pharma signs research collaboration and license option agreement with Lilly. Lyon, France, January 25, 2010. DMI5UEB RU http://www.alz-pharma.com/actualite/alize-pharma-signs-research-collaboration-and-license-option-agreement-with-lilly DMR38M4 DI DMR38M4 DMR38M4 DN UNBS-1450 DMR38M4 MI TTWK8D0 DMR38M4 MN Sodium pump subunit alpha-1 (ATP1A1) DMR38M4 MT DTT DMR38M4 MA Inhibitor DMR38M4 RN Early downregulation of Mcl-1 regulates apoptosis triggered by cardiac glycoside UNBS1450. Cell Death Dis. 2015 Jun 11;6:e1782. DMR38M4 RU https://pubmed.ncbi.nlm.nih.gov/26068790 DMIKV9W DI DMIKV9W DMIKV9W DN Utomilumab DMIKV9W MI TTPW9LJ DMIKV9W MN Co-stimulatory molecule 4-1BB (CD137) DMIKV9W MT DTT DMIKV9W MA Agonist DMIKV9W RN First-in-Human Study of Utomilumab, a 4-1BB/CD137 Agonist, in Combination with Rituximab in Patients with Follicular and Other CD20 + Non-Hodgkin Lymphomas. Clin Cancer Res. 2020 Jun 1;26(11):2524-2534. DMIKV9W RU https://pubmed.ncbi.nlm.nih.gov/32144134 DMJSX9N DI DMJSX9N DMJSX9N DN V-24343 DMJSX9N MI TT6OEDT DMJSX9N MN Cannabinoid receptor 1 (CB1) DMJSX9N MT DTT DMJSX9N MA Antagonist DMJSX9N RN Cannabinoid receptor antagonists: pharmacological opportunities, clinical experience, and translational prognosis. Expert Opin Emerg Drugs. 2009 Mar;14(1):43-65. DMJSX9N RU https://pubmed.ncbi.nlm.nih.gov/19249987 DMYAIUB DI DMYAIUB DMYAIUB DN Valortim DMYAIUB MI TT3YGCD DMYAIUB MN Bacterial Protective antigen (Bact pagA) DMYAIUB MT DTT DMYAIUB RN Phase I Study Evaluating the Safety and Pharmacokinetics of MDX-1303, a Fully Human Monoclonal Antibody against Bacillus anthracis Protective Antigen, in Healthy Volunteers. Clin Vaccine Immunol. 2011 December; 18(12): 2136-2142. DMYAIUB RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3232684/ DM3ZW6A DI DM3ZW6A DM3ZW6A DN VAN-10-4-eluting stent DM3ZW6A MI TT1MG9E DM3ZW6A MN Extracellular signal-regulated kinase 1 (ERK1) DM3ZW6A MT DTT DM3ZW6A MA Inhibitor DM3ZW6A RN WO patent application no. 2013,1850,32, Nanotherapeutics for drug targeting. DM3ZW6A RU http://worldwide.espacenet.com/publicationDetails/biblio?DB=worldwide.espacenet.com&II=0&ND=3&adjacent=true&locale=en_EP&FT=D&date=20131212&CC=WO&NR=2013185032A1&KC=A1 DM3ZW6A DI DM3ZW6A DM3ZW6A DN VAN-10-4-eluting stent DM3ZW6A MI TT4TQBX DM3ZW6A MN Extracellular signal-regulated kinase 2 (ERK2) DM3ZW6A MT DTT DM3ZW6A MA Inhibitor DM3ZW6A RN WO patent application no. 2013,1850,32, Nanotherapeutics for drug targeting. DM3ZW6A RU http://worldwide.espacenet.com/publicationDetails/biblio?DB=worldwide.espacenet.com&II=0&ND=3&adjacent=true&locale=en_EP&FT=D&date=20131212&CC=WO&NR=2013185032A1&KC=A1 DMULRYC DI DMULRYC DMULRYC DN VBY- 036 DMULRYC MI TTUMQVO DMULRYC MN Cathepsin S (CTSS) DMULRYC MT DTT DMULRYC MA Inhibitor DMULRYC RN Clinical pipeline report, company report or official report of ViroBay. DMULRYC RU http://virobayinc.com/VBY-036.php DMTKPH4 DI DMTKPH4 DMTKPH4 DN VBY- 891 DMTKPH4 MI TTUMQVO DMTKPH4 MN Cathepsin S (CTSS) DMTKPH4 MT DTT DMTKPH4 MA Modulator DMTKPH4 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2353). DMTKPH4 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2353 DM4YIWK DI DM4YIWK DM4YIWK DN VBY-129 DM4YIWK MI TTUMQVO DM4YIWK MN Cathepsin S (CTSS) DM4YIWK MT DTT DM4YIWK MA Inhibitor DM4YIWK RN Clinical pipeline report, company report or official report of ViroBay. DM4YIWK RU http://www.virobayinc.com/VBY-129.php DMU263R DI DMU263R DMU263R DN VBY-376 DMU263R MI TTWXB3E DMU263R MN Hepatitis C virus NS3 helicase (HCV NS3) DMU263R MT DTT DMU263R MA Inhibitor DMU263R RN Hepatitis C Virus NS3/4A Protease Inhibitors: A Light at the End of the Tunnel. Viruses. 2010 August; 2(8): 1752-1765. DMU263R RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3185733/ DMMKUOZ DI DMMKUOZ DMMKUOZ DN VCH-286 DMMKUOZ MI TT2CEJG DMMKUOZ MN C-C chemokine receptor type 5 (CCR5) DMMKUOZ MT DTT DMMKUOZ MA Antagonist DMMKUOZ RN The Continuing Evolution of HIV-1 Therapy: Identification and Development of Novel Antiretroviral Agents Targeting Viral and Cellular Targets. Mol Biol Int. 2012;2012:401965. DMMKUOZ RU https://pubmed.ncbi.nlm.nih.gov/22848825 DMS9EKG DI DMS9EKG DMS9EKG DN VCL-1M01 DMS9EKG MI TTF89GD DMS9EKG MN Interleukin-2 (IL2) DMS9EKG MT DTT DMS9EKG MA Modulator DMS9EKG RN Interleukin-2 gene therapy in a patient with glioblastoma. Gene Ther. 1995 Mar;2(2):164-7. DMS9EKG RU https://pubmed.ncbi.nlm.nih.gov/7719933 DMDSC63 DI DMDSC63 DMDSC63 DN VEL-0230 DMDSC63 MI TTDZN01 DMDSC63 MN Cathepsin K (CTSK) DMDSC63 MT DTT DMDSC63 MA Inhibitor DMDSC63 RN Discovery and parallel synthesis of a new class of cathepsin K inhibitors. Bioorg Med Chem Lett. 2001 Nov 19;11(22):2951-4. DMDSC63 RU https://pubmed.ncbi.nlm.nih.gov/11677133 DM9OEK1 DI DM9OEK1 DM9OEK1 DN Velpatasvir DM9OEK1 MI DTUGYRD DM9OEK1 MN P-glycoprotein 1 (ABCB1) DM9OEK1 MT DTP DM9OEK1 MA Substrate DM9OEK1 RN Tarascon Pocket Pharmacopoeia 2018 Classic Shirt-Pocket Edition. DM9OEK1 RU https://books.google.com/books?id=0gBRDwAAQBAJ&pg=PP37&lpg=PP37&dq=Methylergonovine+transporter+uptake+efflex&source=bl&ots=cUTe_ppsmZ&sig=ACfU3U3E_YqrDg0CNEuj8K-7lci47HAnrg&hl=zh-CN&sa=X&ved=2ahUKEwjnj-Dk7d7iAhUsK6YKHd5DBDkQ6AEwEnoECAgQAQ#v=onepage&q&f=false DM9GC4R DI DM9GC4R DM9GC4R DN VGX-100 DM9GC4R MI TT0QUFV DM9GC4R MN Vascular endothelial growth factor C (VEGFC) DM9GC4R MT DTT DM9GC4R MA Modulator DM9GC4R RN National Cancer Institute Drug Dictionary (drug id 724066). DM9GC4R RU http://www.cancer.gov/publications/dictionaries/cancer-drug?cdrid=724066 DMM1N5C DI DMM1N5C DMM1N5C DN VGX-1027 DMM1N5C MI TTXT2VN DMM1N5C MN NF-kappa-B-p38 signaling pathway (NFKB-p38 pathway) DMM1N5C MT DTT DMM1N5C MA Inhibitor DMM1N5C RN Effects of the immunomodulator, VGX-1027, in endotoxin-induced uveitis in Lewis rats. Br J Pharmacol. 2008 Nov;155(5):722-30. DMM1N5C RU https://pubmed.ncbi.nlm.nih.gov/18776919 DMGMEH7 DI DMGMEH7 DMGMEH7 DN VGX-3400 DMGMEH7 MI TTF4CAM DMGMEH7 MN Influenza Hemagglutinin (Influ HA) DMGMEH7 MT DTT DMGMEH7 RN Clinical pipeline report, company report or official report of Inovio Pharmaceuticals. DMGMEH7 RU http://www.inovio.com/products/infectious-disease-vaccines/influenza/pandemic/ DMDFC2Y DI DMDFC2Y DMDFC2Y DN VIC-1911 DMDFC2Y MI TTPS3C0 DMDFC2Y MN Aurora kinase A (AURKA) DMDFC2Y MT DTT DMDFC2Y MA Inhibitor DMDFC2Y RN Clinical pipeline report, company report or official report of VITRAC Therapeutics. DMDFC2Y RU https://vitractherapeutics.com/ DM6LQIU DI DM6LQIU DM6LQIU DN VIR-2482 DM6LQIU MI TTF4CAM DM6LQIU MN Influenza Hemagglutinin (Influ HA) DM6LQIU MT DTT DM6LQIU RN Clinical pipeline report, company report or official report of Vir Biotechnology. DM6LQIU RU https://www.vir.bio/pipeline/ DMB3I04 DI DMB3I04 DMB3I04 DN VM-206 DMB3I04 MI TT6EO5L DMB3I04 MN Erbb2 tyrosine kinase receptor (HER2) DMB3I04 MT DTT DMB3I04 RN WO patent application no. 2014,1441,21, Classification and actionability indices for lung cancer. DMB3I04 RU http://worldwide.espacenet.com/publicationDetails/biblio?DB=worldwide.espacenet.com&II=0&ND=3&adjacent=true&locale=en_EP&FT=D&date=20140918&CC=WO&NR=2014144121A2&KC=A2 DM4AXPT DI DM4AXPT DM4AXPT DN VMD-928 DM4AXPT MI TTTDVOJ DM4AXPT MN Tropomyosin-related kinase A (TrkA) DM4AXPT MT DTT DM4AXPT MA Inhibitor DM4AXPT RN ClinicalTrials.gov (NCT03556228) Oral TrkA Inhibitor VMD-928 for Treatment of Advanced Adult Solid Tumors or Lymphoma. U.S. National Institutes of Health. DM4AXPT RU https://clinicaltrials.gov/ct2/show/NCT03556228 DMNZ6XH DI DMNZ6XH DMNZ6XH DN VNRX-5133 DMNZ6XH MI TTHI19T DMNZ6XH MN Staphylococcus Beta-lactamase (Stap-coc blaZ) DMNZ6XH MT DTT DMNZ6XH MA Inhibitor DMNZ6XH RN Discovery of Taniborbactam (VNRX-5133): A Broad-Spectrum Serine- and Metallo--lactamase Inhibitor for Carbapenem-Resistant Bacterial Infections. J Med Chem. 2020 Mar 26;63(6):2789-2801. DMNZ6XH RU https://pubmed.ncbi.nlm.nih.gov/31765155 DMDG30Q DI DMDG30Q DMDG30Q DN VOB560 DMDG30Q MI TTJGNVC DMDG30Q MN Apoptosis regulator Bcl-2 (BCL-2) DMDG30Q MT DTT DMDG30Q MA Inhibitor DMDG30Q RN Inhibition of Anti-Apoptotic Bcl-2 Proteins in Preclinical and Clinical Studies: Current Overview in Cancer. Cells. 2020 May 21;9(5):1287. DMDG30Q RU https://pubmed.ncbi.nlm.nih.gov/32455818 DM215XO DI DM215XO DM215XO DN Voxilaprevir DM215XO MI DTUGYRD DM215XO MN P-glycoprotein 1 (ABCB1) DM215XO MT DTP DM215XO MA Substrate DM215XO RN Tarascon Pocket Pharmacopoeia 2018 Classic Shirt-Pocket Edition. DM215XO RU https://books.google.com/books?id=0gBRDwAAQBAJ&pg=PP37&lpg=PP37&dq=Methylergonovine+transporter+uptake+efflex&source=bl&ots=cUTe_ppsmZ&sig=ACfU3U3E_YqrDg0CNEuj8K-7lci47HAnrg&hl=zh-CN&sa=X&ved=2ahUKEwjnj-Dk7d7iAhUsK6YKHd5DBDkQ6AEwEnoECAgQAQ#v=onepage&q&f=false DM0S9OT DI DM0S9OT DM0S9OT DN VRC07-523LS DM0S9OT MI TTN2JFW DM0S9OT MN T-cell surface glycoprotein CD4 (CD4) DM0S9OT MT DTT DM0S9OT RN Clinical pipeline report, company report or official report of TaiMed Biologics. DM0S9OT RU http://www.taimedbiologics.com/pipeline/44 DMN9JCD DI DMN9JCD DMN9JCD DN VS-4718 DMN9JCD MI TTON5IT DMN9JCD MN Focal adhesion kinase 1 (FAK) DMN9JCD MT DTT DMN9JCD MA Inhibitor DMN9JCD RN FAK Inhibition disrupts a beta5 integrin signaling axis controlling anchorage-independent ovarian carcinoma growth. Mol Cancer Ther. 2014 Aug;13(8):2050-61. DMN9JCD RU https://pubmed.ncbi.nlm.nih.gov/24899686 DMMO3G5 DI DMMO3G5 DMMO3G5 DN VS-5584 DMMO3G5 MI TTX4GLS DMMO3G5 MN Mammalian target of rapamycin complex 1 (mTORC1) DMMO3G5 MT DTT DMMO3G5 MA Inhibitor DMMO3G5 RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMMO3G5 RU http://phrma-docs.phrma.org/sites/default/files/pdf/medicines-in-development-drug-list-rare-diseases.pdf DMMO3G5 DI DMMO3G5 DMMO3G5 DN VS-5584 DMMO3G5 MI TTHBTOP DMMO3G5 MN PI3-kinase gamma (PIK3CG) DMMO3G5 MT DTT DMMO3G5 MA Modulator DMMO3G5 RN VS-5584, a novel and highly selective PI3K/mTOR kinase inhibitor for the treatment of cancer. Mol Cancer Ther. 2013 Feb;12(2):151-61. DMMO3G5 RU https://pubmed.ncbi.nlm.nih.gov/23270925 DMMO3G5 DI DMMO3G5 DMMO3G5 DN VS-5584 DMMO3G5 MI TTCJG29 DMMO3G5 MN Serine/threonine-protein kinase mTOR (mTOR) DMMO3G5 MT DTT DMMO3G5 MA Modulator DMMO3G5 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2109). DMMO3G5 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2109 DMMO3G5 DI DMMO3G5 DMMO3G5 DN VS-5584 DMMO3G5 MI TTWDKCL DMMO3G5 MN Target of rapamycin complex 2 MAPKAP1 (MTORC2) DMMO3G5 MT DTT DMMO3G5 MA Inhibitor DMMO3G5 RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMMO3G5 RU http://phrma-docs.phrma.org/sites/default/files/pdf/medicines-in-development-drug-list-rare-diseases.pdf DMQEOD6 DI DMQEOD6 DMQEOD6 DN VTP-27999 DMQEOD6 MI TTB2MXP DMQEOD6 MN Angiotensinogenase renin (REN) DMQEOD6 MT DTT DMQEOD6 MA Inhibitor DMQEOD6 RN New Developments in the Pharmacological Treatment of Hypertension: Dead-End or a Glimmer at the Horizon . Curr Hypertens Rep. 2015; 17(6): 42. DMQEOD6 RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4412646/ DM9W0B6 DI DM9W0B6 DM9W0B6 DN VTR-297 DM9W0B6 MI TTBH0VX DM9W0B6 MN Histone deacetylase (HDAC) DM9W0B6 MT DTT DM9W0B6 MA Inhibitor DM9W0B6 RN Clinical pipeline report, company report or official report of Vanda Pharmaceuticals. DM9W0B6 RU https://vandapharmaceuticalsinc.gcs-web.com/news-releases/news-release-details/vanda-pharmaceuticals-reports-third-quarter-2019-financial DM4ZIRK DI DM4ZIRK DM4ZIRK DN VTX-1463 DM4ZIRK MI TT8CWFK DM4ZIRK MN Toll-like receptor 8 (TLR8) DM4ZIRK MT DTT DM4ZIRK MA Agonist DM4ZIRK RN VTX-1463, a novel TLR8 agonist for the treatment of allergic rhinitis. Expert Opin Investig Drugs. 2011 Jul;20(7):981-6. DM4ZIRK RU https://pubmed.ncbi.nlm.nih.gov/21548830 DMC8J0G DI DMC8J0G DMC8J0G DN VX-128 DMC8J0G MI TT90XZ8 DMC8J0G MN Voltage-gated sodium channel alpha Nav1.8 (SCN10A) DMC8J0G MT DTT DMC8J0G MA Inhibitor DMC8J0G RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMC8J0G RU http://phrma-docs.phrma.org/files/dmfile/MID_Neurological-Disorders-Drug-List_2018.pdf DM8UTPJ DI DM8UTPJ DM8UTPJ DN VX-500 DM8UTPJ MI TT5FNQT DM8UTPJ MN Human immunodeficiency virus Protease (HIV PR) DM8UTPJ MT DTT DM8UTPJ MA Inhibitor DM8UTPJ RN 2011 Pipeline of Vertex. DM8UTPJ RU http://www.vrtx.com/current-projects.html DMAJ2T4 DI DMAJ2T4 DMAJ2T4 DN VX-916 DMAJ2T4 MI TTMVBWH DMAJ2T4 MN Hepatitis C virus RNA-directed RNA polymerase (HCV NS5B) DMAJ2T4 MT DTT DMAJ2T4 MA Inhibitor DMAJ2T4 RN 2011 Pipeline of Vertex. DMAJ2T4 RU http://www.vrtx.com/current-projects.html DMR9PCT DI DMR9PCT DMR9PCT DN VX-970 DMR9PCT MI TT8ZYBQ DMR9PCT MN Serine/threonine-protein kinase ATR (FRP1) DMR9PCT MT DTT DMR9PCT MA Inhibitor DMR9PCT RN ATR inhibitors VE-821 and VX-970 sensitize cancer cells to topoisomerase i inhibitors by disabling DNA replication initiation and fork elongation responses. Cancer Res. 2014 Dec 1;74(23):6968-79. DMR9PCT RU https://pubmed.ncbi.nlm.nih.gov/25269479 DMC9N7D DI DMC9N7D DMC9N7D DN VYR 006 DMC9N7D MI TTYZVDJ DMC9N7D MN Dihydrofolate reductase (DHFR) DMC9N7D MT DTT DMC9N7D MA Inhibitor DMC9N7D RN Clinical pipeline report, company report or official report of Vyera Pharmaceuticals. DMC9N7D RU https://www.vyera.com/news-center/vyera-pharmaceuticals-has-initiated-a-phase-1-study-of-a-new-dihydrofolate-reductase-inhibitor-designed-as-a-potential-treatment-for-toxoplasmosis DMJ2R69 DI DMJ2R69 DMJ2R69 DN W-198 DMJ2R69 MI TT3OT40 DMJ2R69 MN Multidrug resistance protein 1 (ABCB1) DMJ2R69 MT DTT DMJ2R69 MA Modulator DMJ2R69 RN Mechanisms of tetrandrine and 5-bromotetrandrine in reversing multidrug resistance may relate to down-regulation of multidrug resistance associated protein 7 expression. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2012 Jun;20(3):558-63. DMJ2R69 RU https://pubmed.ncbi.nlm.nih.gov/22739155 DMJQHTN DI DMJQHTN DMJQHTN DN WCK-1152 DMJQHTN MI TTIXTO3 DMJQHTN MN Staphylococcus Topoisomerase IV (Stap-coc parC) DMJQHTN MT DTT DMJQHTN MA Modulator DMJQHTN RN DOI: 10.1093/jac/dki361 DMJQHTN RU http://jac.oxfordjournals.org/content/56/6/1130.full.pdf DM57FHW DI DM57FHW DM57FHW DN WF-11605 DM57FHW MI TTTWGIX DM57FHW MN Leukotriene receptor (LTR) DM57FHW MT DTT DM57FHW MA Modulator DM57FHW RN WF11605, an antagonist of leukotriene B4 produced by a fungus. II. Structure determination. J Antibiot (Tokyo). 1992 May;45(5):704-8. DM57FHW RU https://pubmed.ncbi.nlm.nih.gov/1320602 DM8RNSB DI DM8RNSB DM8RNSB DN WP1220 DM8RNSB MI TTH8FZW DM8RNSB MN Signal transducer and activator of transcription 3 (STAT3) DM8RNSB MT DTT DM8RNSB MA Inhibitor DM8RNSB RN Clinical pipeline report, company report or official report of Moleculin Biotech. DM8RNSB RU https://www.moleculin.com/technology/wp1220/ DM9PNR6 DI DM9PNR6 DM9PNR6 DN WST-057 DM9PNR6 MI TTZ9SOR DM9PNR6 MN Muscarinic acetylcholine receptor M1 (CHRM1) DM9PNR6 MT DTT DM9PNR6 MA Antagonist DM9PNR6 RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DM9PNR6 RU http://phrma-docs.phrma.org/files/dmfile/MID_Neurological-Disorders-Drug-List_2018.pdf DM7MS10 DI DM7MS10 DM7MS10 DN WVT078 DM7MS10 MI TTZ3P4W DM7MS10 MN B-cell maturation protein (TNFRSF17) DM7MS10 MT DTT DM7MS10 RN ClinicalTrials.gov (NCT04123418) A Study of WVT078 in Patients With Multiple Myeloma (MM). U.S. National Institutes of Health. DM7MS10 RU https://clinicaltrials.gov/ct2/show/NCT04123418 DM7MS10 DI DM7MS10 DM7MS10 DN WVT078 DM7MS10 MI TTUN7MC DM7MS10 MN T-cell surface glycoprotein CD3 (CD3) DM7MS10 MT DTT DM7MS10 RN ClinicalTrials.gov (NCT04123418) A Study of WVT078 in Patients With Multiple Myeloma (MM). U.S. National Institutes of Health. DM7MS10 RU https://clinicaltrials.gov/ct2/show/NCT04123418 DMFBOQ7 DI DMFBOQ7 DMFBOQ7 DN Xanthine DMFBOQ7 MI TTNE7KG DMFBOQ7 MN Adenosine A2b receptor (ADORA2B) DMFBOQ7 MT DTT DMFBOQ7 MA Antagonist DMFBOQ7 RN Role of adenosine in asthma. Drug Dev Res. 1996;39:333-6. DMFBOQ7 RU https://pubmed.ncbi.nlm.nih.gov/11542498 DMFBOQ7 DI DMFBOQ7 DMFBOQ7 DN Xanthine DMFBOQ7 MI DEJGDUW DMFBOQ7 MN Cytochrome P450 1A2 (CYP1A2) DMFBOQ7 MT DME DMFBOQ7 MA Metabolism DMFBOQ7 RN Rapid determination of five probe drugs and their metabolites in human plasma and urine by liquid chromatography/tandem mass spectrometry: application to cytochrome P450 phenotyping studies. Rapid Commun Mass Spectrom. 2004;18(23):2921-33. DMFBOQ7 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=15529418 DMFBOQ7 DI DMFBOQ7 DMFBOQ7 DN Xanthine DMFBOQ7 MI DECG04O DMFBOQ7 MN Xanthine dehydrogenase/oxidase (XDH) DMFBOQ7 MT DME DMFBOQ7 MA Metabolism DMFBOQ7 RN Molecular characterization and taurine regulation of two novel CDOs (CDO1 and CDO2) from Carassius auratus. Comp Biochem Physiol B Biochem Mol Biol. 2019 Sep;235:54-61. DMFBOQ7 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=31176866 DM1UIOA DI DM1UIOA DM1UIOA DN XB-947 DM1UIOA MI TT4NVEM DM1UIOA MN DNA topoisomerase II beta (TOP2B) DM1UIOA MT DTT DM1UIOA MA Modulator DM1UIOA RN XK469, a selective topoisomerase IIbeta poison. Proc Natl Acad Sci U S A. 1999 October 12; 96(21): 12168-12173. DM1UIOA RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC18430/ DMNKV3O DI DMNKV3O DMNKV3O DN XEN007 DMNKV3O MI TTX4QDJ DMNKV3O MN Voltage-gated calcium channel alpha Cav2.1 (CACNA1A) DMNKV3O MT DTT DMNKV3O MA Inhibitor DMNKV3O RN Antibodies and venom peptides: new modalities for ion channels. Nat Rev Drug Discov. 2019 May;18(5):339-357. DMNKV3O RU https://pubmed.ncbi.nlm.nih.gov/30728472 DMJVL57 DI DMJVL57 DMJVL57 DN XEN1101 DMJVL57 MI TTIVDM3 DMJVL57 MN Voltage-gated potassium channel Kv7.3 (KCNQ3) DMJVL57 MT DTT DMJVL57 MA Activator DMJVL57 RN Antibodies and venom peptides: new modalities for ion channels. Nat Rev Drug Discov. 2019 May;18(5):339-357. DMJVL57 RU https://pubmed.ncbi.nlm.nih.gov/30728472 DMRP9YF DI DMRP9YF DMRP9YF DN XEN901 DMRP9YF MI TT54ERL DMRP9YF MN Voltage-gated sodium channel alpha Nav1.6 (SCN8A) DMRP9YF MT DTT DMRP9YF MA Inhibitor DMRP9YF RN Antibodies and venom peptides: new modalities for ion channels. Nat Rev Drug Discov. 2019 May;18(5):339-357. DMRP9YF RU https://pubmed.ncbi.nlm.nih.gov/30728472 DMU0V45 DI DMU0V45 DMU0V45 DN XEN-D0101 DMU0V45 MI TTW0CMT DMU0V45 MN Voltage-gated potassium channel Kv1.5 (KCNA5) DMU0V45 MT DTT DMU0V45 MA Modulator DMU0V45 RN Human electrophysiological and pharmacological properties of XEN-D0101: a novel atrial-selective Kv1.5/IKur inhibitor. J Cardiovasc Pharmacol. 2013 May;61(5):408-15. DMU0V45 RU https://pubmed.ncbi.nlm.nih.gov/23364608 DMR0U4V DI DMR0U4V DMR0U4V DN XEN-D0103 DMR0U4V MI TTW0CMT DMR0U4V MN Voltage-gated potassium channel Kv1.5 (KCNA5) DMR0U4V MT DTT DMR0U4V MA Inhibitor DMR0U4V RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 542). DMR0U4V RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=542 DMVYO41 DI DMVYO41 DMVYO41 DN XK-469 DMVYO41 MI TT4NVEM DMVYO41 MN DNA topoisomerase II beta (TOP2B) DMVYO41 MT DTT DMVYO41 MA Modulator DMVYO41 RN A pharmacogenetic study of aldehyde oxidase I in patients treated with XK469.Pharmacogenet Genomics.2014 Feb;24(2):129-32. DMVYO41 RU https://www.ncbi.nlm.nih.gov/pubmed/24300566 DMYSQHT DI DMYSQHT DMYSQHT DN XL-041 DMYSQHT MI TTM1EQF DMYSQHT MN Oxysterols receptor LXR (NR1H) DMYSQHT MT DTT DMYSQHT MA Modulator DMYSQHT RN Emerging small molecule drugs. Handb Exp Pharmacol. 2015;224:617-30. DMYSQHT RU https://pubmed.ncbi.nlm.nih.gov/25523004 DM3LRAC DI DM3LRAC DM3LRAC DN XL092 DM3LRAC MI TTNDSF4 DM3LRAC MN Proto-oncogene c-Met (MET) DM3LRAC MT DTT DM3LRAC MA Inhibitor DM3LRAC RN Clinical pipeline report, company report or official report of Exelixis. DM3LRAC RU https://www.exelixis.com/pipeline/ DM3LRAC DI DM3LRAC DM3LRAC DN XL092 DM3LRAC MI TTVJ1D8 DM3LRAC MN Vascular endothelial growth factor receptor (VEGFR) DM3LRAC MT DTT DM3LRAC MA Inhibitor DM3LRAC RN Clinical pipeline report, company report or official report of Exelixis. DM3LRAC RU https://www.exelixis.com/pipeline/ DME0F5W DI DME0F5W DME0F5W DN XL418 DME0F5W MI TTAZ05C DME0F5W MN RAC-gamma serine/threonine-protein kinase (AKT3) DME0F5W MT DTT DME0F5W MA Modulator DME0F5W RN Targeting the phosphoinositide 3-kinase (PI3K) pathway in cancer DME0F5W RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3142564 DME0F5W DI DME0F5W DME0F5W DN XL418 DME0F5W MI TT7M3PI DME0F5W MN Ribosomal protein S6 kinase (S6K) DME0F5W MT DTT DME0F5W MA Modulator DME0F5W RN Targeting the phosphoinositide 3-kinase (PI3K) pathway in cancer DME0F5W RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3142564 DMY93SW DI DMY93SW DMY93SW DN XL550 DMY93SW MI TT26PHO DMY93SW MN Mineralocorticoid receptor (MR) DMY93SW MT DTT DMY93SW MA Antagonist DMY93SW RN Clinical pipeline report, company report or official report of Exelixis (2011). DMY93SW RU http://www.exelixis.com/pipeline DM89NML DI DM89NML DM89NML DN XL652/XL014 DM89NML MI TTM1EQF DM89NML MN Oxysterols receptor LXR (NR1H) DM89NML MT DTT DM89NML MA Modulator DM89NML RN Clinical pipeline report, company report or official report of Exelixis (2011). DM89NML RU http://www.exelixis.com/pipeline DMYS13R DI DMYS13R DMYS13R DN XL999 DMYS13R MI TTUTJGQ DMYS13R MN Vascular endothelial growth factor receptor 2 (KDR) DMYS13R MT DTT DMYS13R MA Inhibitor DMYS13R RN Gateways to clinical trials. Methods Find Exp Clin Pharmacol. 2007 Mar;29(2):153-73. DMYS13R RU https://pubmed.ncbi.nlm.nih.gov/17440629 DMXTOCE DI DMXTOCE DMXTOCE DN XmAb13676 DMXTOCE MI TTUE541 DMXTOCE MN Leukocyte surface antigen Leu-16 (CD20) DMXTOCE MT DTT DMXTOCE RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMXTOCE RU http://phrma-docs.phrma.org/files/dmfile/MID_Immuno-Oncology-2017_Drug-List1.pdf DMJIH83 DI DMJIH83 DMJIH83 DN XmAb20717 DMJIH83 MI TTI2S1D DMJIH83 MN Cytotoxic T-lymphocyte protein 4 (CTLA-4) DMJIH83 MT DTT DMJIH83 RN Clinical pipeline report, company report or official report of Xencor. DMJIH83 RU https://xencor.com/pipeline/xmab20717/ DMJIH83 DI DMJIH83 DMJIH83 DN XmAb20717 DMJIH83 MI TTNBFWK DMJIH83 MN Programmed cell death protein 1 (PD-1) DMJIH83 MT DTT DMJIH83 RN Clinical pipeline report, company report or official report of Xencor. DMJIH83 RU https://xencor.com/pipeline/xmab20717/ DMQB3HD DI DMQB3HD DMQB3HD DN XmAb22841 DMQB3HD MI TTI2S1D DMQB3HD MN Cytotoxic T-lymphocyte protein 4 (CTLA-4) DMQB3HD MT DTT DMQB3HD RN Clinical pipeline report, company report or official report of Xencor. DMQB3HD RU https://xencor.com/pipeline/xmab22841/ DMQB3HD DI DMQB3HD DMQB3HD DN XmAb22841 DMQB3HD MI TTNVXAW DMQB3HD MN Lymphocyte activation gene 3 protein (LAG3) DMQB3HD MT DTT DMQB3HD RN Clinical pipeline report, company report or official report of Xencor. DMQB3HD RU https://xencor.com/pipeline/xmab22841/ DMK9XUQ DI DMK9XUQ DMK9XUQ DN XmAb23104 DMK9XUQ MI TTE5VP6 DMK9XUQ MN Inducible T-cell costimulator (ICOS) DMK9XUQ MT DTT DMK9XUQ RN Clinical pipeline report, company report or official report of Xencor. DMK9XUQ RU https://xencor.com/pipeline/xmab23104/ DMK9XUQ DI DMK9XUQ DMK9XUQ DN XmAb23104 DMK9XUQ MI TTNBFWK DMK9XUQ MN Programmed cell death protein 1 (PD-1) DMK9XUQ MT DTT DMK9XUQ RN Clinical pipeline report, company report or official report of Xencor. DMK9XUQ RU https://xencor.com/pipeline/xmab23104/ DM6V0KY DI DM6V0KY DM6V0KY DN Xmab-2513 DM6V0KY MI TT2GM5R DM6V0KY MN Lymphocyte activation antigen CD30 (TNFRSF8) DM6V0KY MT DTT DM6V0KY RN Phase I study of an anti-CD30 Fc engineered humanized monoclonal antibody in Hodgkin lymphoma (HL) or anaplastic large cell lymphoma (ALCL) patients: Safety, pharmacokinetics (PK), immunogenicity, and efficacy. J Clin Oncol (Meeting Abstracts) May 2009 vol. 27 no. 15S 8531. DM6V0KY RU http://meeting.ascopubs.org/cgi/content/abstract/27/15S/8531 DME7IVL DI DME7IVL DME7IVL DN Xmab-7195 DME7IVL MI TTYJQTF DME7IVL MN Immunoglobulin E (IgE) DME7IVL MT DTT DME7IVL MA Inhibitor DME7IVL RN Clinical pipeline report, company report or official report of Xencor. DME7IVL RU http://www.xencor.com/pipeline/xmab7195/ DM4MDCH DI DM4MDCH DM4MDCH DN XMT-1001 DM4MDCH MI TTGTQHC DM4MDCH MN DNA topoisomerase I (TOP1) DM4MDCH MT DTT DM4MDCH MA Inhibitor DM4MDCH RN Pharmacokinetics and antitumor efficacy of XMT-1001, a novel, polymeric topoisomerase I inhibitor, in mice bearing HT-29 human colon carcinoma xenografts. Clin Cancer Res. 2012 May 1;18(9):2591-602. DM4MDCH RU https://pubmed.ncbi.nlm.nih.gov/22392910 DMK0AW6 DI DMK0AW6 DMK0AW6 DN XOMA-3AB DMK0AW6 MI TTB52WU DMK0AW6 MN Bacterial Botulinum toxin A (Bact botA) DMK0AW6 MT DTT DMK0AW6 RN Clinical pipeline report, company report or official report of XOMA. DMK0AW6 RU http://www.xoma.com/content/pipeline/biodefense.htm DMO9KZE DI DMO9KZE DMO9KZE DN XR-5944 DMO9KZE MI TT0IHXV DMO9KZE MN DNA topoisomerase II (TOP2) DMO9KZE MT DTT DMO9KZE MA Modulator DMO9KZE RN Antitumor activity of XR5944, a novel and potent topoisomerase poison. Anticancer Drugs. 2001 Apr;12(4):359-67. DMO9KZE RU https://pubmed.ncbi.nlm.nih.gov/11335793 DML3K9N DI DML3K9N DML3K9N DN XTL-6865 DML3K9N MI TTDBG95 DML3K9N MN Hepatitis C virus Envelope glycoprotein E2 (HCV NS1) DML3K9N MT DTT DML3K9N MA Modulator DML3K9N RN Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41. DML3K9N RU https://www.ncbi.nlm.nih.gov/pubmed/15950434 DMKHVNE DI DMKHVNE DMKHVNE DN YKP-1358 DMKHVNE MI TTJQOD7 DMKHVNE MN 5-HT 2A receptor (HTR2A) DMKHVNE MT DTT DMKHVNE MA Modulator DMKHVNE RN Modeling of brain D2 receptor occupancy-plasma concentration relationships with a novel antipsychotic, YKP1358, using serial PET scans in healthy volunteers. Clin Pharmacol Ther. 2007 Feb;81(2):252-8. DMKHVNE RU https://pubmed.ncbi.nlm.nih.gov/17259948 DMKHVNE DI DMKHVNE DMKHVNE DN YKP-1358 DMKHVNE MI TTEX248 DMKHVNE MN Dopamine D2 receptor (D2R) DMKHVNE MT DTT DMKHVNE MA Modulator DMKHVNE RN Modeling of brain D2 receptor occupancy-plasma concentration relationships with a novel antipsychotic, YKP1358, using serial PET scans in healthy volunteers. Clin Pharmacol Ther. 2007 Feb;81(2):252-8. DMKHVNE RU https://pubmed.ncbi.nlm.nih.gov/17259948 DMW2HS8 DI DMW2HS8 DMW2HS8 DN YM-116 DMW2HS8 MI TTC8NQ2 DMW2HS8 MN Lyase unspecific (LYA) DMW2HS8 MT DTT DMW2HS8 MA Inhibitor DMW2HS8 RN YM116, 2-(1H-imidazol-4-ylmethyl)-9H-carbazole, decreases adrenal androgen synthesis by inhibiting C17-20 lyase activity in NCI-H295 human adrenocortical carcinoma cells. Jpn J Pharmacol. 1999 Feb;79(2):213-20. DMW2HS8 RU https://pubmed.ncbi.nlm.nih.gov/10202857 DMNLY9R DI DMNLY9R DMNLY9R DN YM-16151-4 DMNLY9R MI TTR6W5O DMNLY9R MN Adrenergic receptor beta-1 (ADRB1) DMNLY9R MT DTT DMNLY9R MA Modulator DMNLY9R RN Antianginal effects of YM-16151-4 in various experimental angina models. J Cardiovasc Pharmacol. 1993 May;21(5):701-8. DMNLY9R RU https://pubmed.ncbi.nlm.nih.gov/7685438 DMNLY9R DI DMNLY9R DMNLY9R DN YM-16151-4 DMNLY9R MI TT5HONZ DMNLY9R MN Calcium channel unspecific (CaC) DMNLY9R MT DTT DMNLY9R MA Modulator DMNLY9R RN Antianginal effects of YM-16151-4 in various experimental angina models. J Cardiovasc Pharmacol. 1993 May;21(5):701-8. DMNLY9R RU https://pubmed.ncbi.nlm.nih.gov/7685438 DMS31YW DI DMS31YW DMS31YW DN YM-57158 DMS31YW MI TTGKOY9 DMS31YW MN Leukotriene CysLT1 receptor (CYSLTR1) DMS31YW MT DTT DMS31YW MA Modulator DMS31YW RN In vitro pharmacologic profile of YM158, a new dual antagonist for LTD4 and TXA2 receptors. J Pharmacol Exp Ther. 1998 Nov;287(2):633-9. DMS31YW RU https://pubmed.ncbi.nlm.nih.gov/9808690 DMS31YW DI DMS31YW DMS31YW DN YM-57158 DMS31YW MI TT2O84V DMS31YW MN Thromboxane A2 receptor (TBXA2R) DMS31YW MT DTT DMS31YW MA Modulator DMS31YW RN In vitro pharmacologic profile of YM158, a new dual antagonist for LTD4 and TXA2 receptors. J Pharmacol Exp Ther. 1998 Nov;287(2):633-9. DMS31YW RU https://pubmed.ncbi.nlm.nih.gov/9808690 DMCM0K6 DI DMCM0K6 DMCM0K6 DN YPEG-Somatropin DMCM0K6 MI TTT3YKH DMCM0K6 MN Somatotropin (GH1) DMCM0K6 MT DTT DMCM0K6 MA Modulator DMCM0K6 RN Somatropin therapy in adults with Prader-Willi syndrome. Treat Endocrinol. 2004;3(3):153-60. DMCM0K6 RU https://pubmed.ncbi.nlm.nih.gov/16026111 DM5BMIO DI DM5BMIO DM5BMIO DN YTB323 DM5BMIO MI TTW640A DM5BMIO MN B-lymphocyte surface antigen B4 (CD19) DM5BMIO MT DTT DM5BMIO RN Clinical pipeline report, company report or official report of Novartis. DM5BMIO RU https://www.novartis.com/our-science/novartis-global-pipeline?search_api_views_fulltext=YTB323&field_pipeline_filing_date=All DM1H75D DI DM1H75D DM1H75D DN Z-100 DM1H75D MI TTV2CN0 DM1H75D MN Interferon receptor (IFNR) DM1H75D MT DTT DM1H75D MA Modulator DM1H75D RN Inhibition of human immunodeficiency virus type 1 replication by Z-100, an immunomodulator extracted from human-type tubercle bacilli, in macrophages. J Gen Virol. 2004 Sep;85(Pt 9):2603-13. DM1H75D RU https://pubmed.ncbi.nlm.nih.gov/15302954 DMZQP7N DI DMZQP7N DMZQP7N DN ZD7114 DMZQP7N MI TTMXGCW DMZQP7N MN Adrenergic receptor beta-3 (ADRB3) DMZQP7N MT DTT DMZQP7N MA Agonist DMZQP7N RN Urinary tract toxicity in rats following administration of beta 3-adrenoceptor agonists. Toxicol Pathol. 1999 Mar-Apr;27(2):165-70. DMZQP7N RU https://pubmed.ncbi.nlm.nih.gov/10207980 DM3KYO4 DI DM3KYO4 DM3KYO4 DN ZD-9379 DM3KYO4 MI TTZ8EM9 DM3KYO4 MN Glycine receptor (GlyR) DM3KYO4 MT DTT DM3KYO4 MA Modulator DM3KYO4 RN Neuroprotective potential of ionotropic glutamate receptor antagonists. Neurotox Res. 2002 Mar;4(2):119-26. DM3KYO4 RU https://pubmed.ncbi.nlm.nih.gov/12829411 DM2S04R DI DM2S04R DM2S04R DN Zemab DM2S04R MI TT6EO5L DM2S04R MN Erbb2 tyrosine kinase receptor (HER2) DM2S04R MT DTT DM2S04R RN Immunotoxins and Anticancer Drug Conjugate Assemblies: The Role of the Linkage between Components. Toxins (Basel) 2011 July; 3(7): 848-883. DM2S04R RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3202854/ DM72GZV DI DM72GZV DM72GZV DN ZEN003694 DM72GZV MI TTE4BSY DM72GZV MN Bromodomain and extraterminal domain protein (BET) DM72GZV MT DTT DM72GZV MA Inhibitor DM72GZV RN Clinical pipeline report, company report or official report of Zenith Epigenetics. DM72GZV RU https://www.zenithepigenetics.com/programs/pipeline DM2LHPU DI DM2LHPU DM2LHPU DN ZK-200775 DM2LHPU MI TTAN6JD DM2LHPU MN Glutamate receptor AMPA (GRIA) DM2LHPU MT DTT DM2LHPU MA Inhibitor DM2LHPU RN Synthesis of anticonvulsive AMPA antagonists: 4-oxo-10-substituted-imidaz. Bioorg Med Chem Lett. 2001 May 7;11(9):1205-10. DM2LHPU RU https://pubmed.ncbi.nlm.nih.gov/11354378 DMTNUA4 DI DMTNUA4 DMTNUA4 DN ZL-1201 DMTNUA4 MI TT28S46 DMTNUA4 MN Leukocyte surface antigen CD47 (CD47) DMTNUA4 MT DTT DMTNUA4 RN Clinical pipeline report, company report or official report of ZAI Lab. DMTNUA4 RU http://www.zailaboratory.com/pipeline/list.aspx DMX6AJ8 DI DMX6AJ8 DMX6AJ8 DN ZM-H1505R DMX6AJ8 MI TTM42UJ DMX6AJ8 MN Hepatitis B virus Capsid protein (HBV C) DMX6AJ8 MT DTT DMX6AJ8 MA Inhibitor DMX6AJ8 RN Clinical pipeline report, company report or official report of Shanghai Zhimeng Biopharma. DMX6AJ8 RU http://www.core-biopharma.com/pipeline.html DMGTL8Z DI DMGTL8Z DMGTL8Z DN ZP-1848 DMGTL8Z MI TT1YWO5 DMGTL8Z MN Glucagon-like peptide 2 receptor (GLP2R) DMGTL8Z MT DTT DMGTL8Z MA Modulator DMGTL8Z RN US patent application no. 8,580,918, Peptidic glp-2 agonists. DMGTL8Z RU http://www.google.com/patents/US8580918 DMRVDUM DI DMRVDUM DMRVDUM DN ZP2929 DMRVDUM MI TT0NUFM DMRVDUM MN Glucagon (GCG) DMRVDUM MT DTT DMRVDUM MA Agonist DMRVDUM RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMRVDUM RU http://phrma-docs.phrma.org/files/dmfile/mid-diabetes-drug-list.pdf DMRVDUM DI DMRVDUM DMRVDUM DN ZP2929 DMRVDUM MI TT9O6WS DMRVDUM MN Glucagon receptor (GCGR) DMRVDUM MT DTT DMRVDUM MA Modulator DMRVDUM RN Company report (Zealandpharma) DMRVDUM RU http://www.zealandpharma.com/product-pipeline/proprietary-pipeline/zp2929 DMRVDUM DI DMRVDUM DMRVDUM DN ZP2929 DMRVDUM MI TTVIMDE DMRVDUM MN Glucagon-like peptide 1 receptor (GLP1R) DMRVDUM MT DTT DMRVDUM MA Modulator DMRVDUM RN Company report (Zealandpharma) DMRVDUM RU http://www.zealandpharma.com/product-pipeline/proprietary-pipeline/zp2929 DMVIMQX DI DMVIMQX DMVIMQX DN ZSTK474 DMVIMQX MI TTHBTOP DMVIMQX MN PI3-kinase gamma (PIK3CG) DMVIMQX MT DTT DMVIMQX MA Modulator DMVIMQX RN Combination of the PI3K inhibitor ZSTK474 with a PSMA-targeted immunotoxin accelerates apoptosis and regression of prostate cancer. Neoplasia. 2013 Oct;15(10):1172-83. DMVIMQX RU https://pubmed.ncbi.nlm.nih.gov/24204196 DMO2WYX DI DMO2WYX DMO2WYX DN ZT-1 DMO2WYX MI TT1RS9F DMO2WYX MN Acetylcholinesterase (AChE) DMO2WYX MT DTT DMO2WYX MA Inhibitor DMO2WYX RN A sensitive method for the determination of the novel cholinesterase inhibitor ZT-1 and its active metabolite huperzine A in rat blood using liquid chromatography/tandem mass spectrometry. Rapid Commun Mass Spectrom. 2004;18(6):651-6. DMO2WYX RU https://pubmed.ncbi.nlm.nih.gov/15052575 DMAU8L9 DI DMAU8L9 DMAU8L9 DN ZW49 DMAU8L9 MI TT6EO5L DMAU8L9 MN Erbb2 tyrosine kinase receptor (HER2) DMAU8L9 MT DTT DMAU8L9 MA Inhibitor DMAU8L9 RN Clinical pipeline report, company report or official report of Zymeworks. DMAU8L9 RU https://www.zymeworks.com/pipeline#zw49 DMSLPTO DI DMSLPTO DMSLPTO DN ZY01 DMSLPTO MI TT6OEDT DMSLPTO MN Cannabinoid receptor 1 (CB1) DMSLPTO MT DTT DMSLPTO MA Antagonist DMSLPTO RN 2011 Pipeline of Zydus Cadila Group. DMSLPTO RU http://www.zyduscadila.com/ DM796RI DI DM796RI DM796RI DN ZYAN1 DM796RI MI TTJQFBG DM796RI MN HIF-prolyl hydroxylase (HPH) DM796RI MT DTT DM796RI MA Inhibitor DM796RI RN Pharmacological Characterization of ZYAN1, a Novel Prolyl Hydroxylase Inhibitor for the Treatment of Anemia. Drug Res (Stuttg). 2016 Feb;66(2):107-12. DM796RI RU https://pubmed.ncbi.nlm.nih.gov/26367279 DMU2D0B DI DMU2D0B DMU2D0B DN ZYDPLA 1 DMU2D0B MI TTDIGC1 DMU2D0B MN Dipeptidyl peptidase 4 (DPP-4) DMU2D0B MT DTT DMU2D0B MA Inhibitor DMU2D0B RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMU2D0B RU http://phrma-docs.phrma.org/files/dmfile/mid-diabetes-drug-list.pdf DM4IG16 DI DM4IG16 DM4IG16 DN ZYGK-1 DM4IG16 MI TTDLNGZ DM4IG16 MN Glucokinase (GCK) DM4IG16 MT DTT DM4IG16 MA Activator DM4IG16 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2798). DM4IG16 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2798 DMZ6042 DI DMZ6042 DMZ6042 DN ZYOG1 DMZ6042 MI TTVIMDE DMZ6042 MN Glucagon-like peptide 1 receptor (GLP1R) DMZ6042 MT DTT DMZ6042 MA Agonist DMZ6042 RN 2011 Pipeline of Zydus Cadila Group. DMZ6042 RU http://www.zyduscadila.com/ DM1XOZK DI DM1XOZK DM1XOZK DN ZYT-1 DM1XOZK MI TTGER3L DM1XOZK MN Thyroid hormone receptor beta (THRB) DM1XOZK MT DTT DM1XOZK MA Modulator DM1XOZK RN Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41. DM1XOZK RU https://www.ncbi.nlm.nih.gov/pubmed/15950434 DMX1ZQV DI DMX1ZQV DMX1ZQV DN (S)-DRF-1042 DMX1ZQV MI TTGTQHC DMX1ZQV MN DNA topoisomerase I (TOP1) DMX1ZQV MT DTT DMX1ZQV MA Inhibitor DMX1ZQV RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2636). DMX1ZQV RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2636 DMN2I3P DI DMN2I3P DMN2I3P DN alpha-ketothiazole analogue 36 DMN2I3P MI TTDM4ZU DMN2I3P MN Factor XI messenger RNA (F11 mRNA) DMN2I3P MT DTT DMN2I3P MA Inhibitor DMN2I3P RN Inhibitors of proteases and amide hydrolases that employ an alpha-ketoheterocycle as a key enabling functionality. Bioorg Med Chem. 2008 Feb 15;16(4):1562-95. DMN2I3P RU https://pubmed.ncbi.nlm.nih.gov/18053726 DM6NVPT DI DM6NVPT DM6NVPT DN Anti-CD19 Chimeric Antigen Receptor T Cells DM6NVPT MI TTW640A DM6NVPT MN B-lymphocyte surface antigen B4 (CD19) DM6NVPT MT DTT DM6NVPT MA CAR-T-Cell-Therapy DM6NVPT RN ClinicalTrials.gov (NCT03624686) Production of Clinical-grade Anti-CD19 Chimeric Antigen Receptor T Cells for Refractory B-cell Malignancies DM6NVPT RU https://clinicaltrials.gov/ct2/show/NCT03624686 DM3M9OY DI DM3M9OY DM3M9OY DN Anti-CD19/20-CAR vector-transduced T cells DM3M9OY MI TTW640A DM3M9OY MN B-lymphocyte surface antigen B4 (CD19) DM3M9OY MT DTT DM3M9OY MA CAR-T-Cell-Therapy(Dual specific) DM3M9OY RN ClinicalTrials.gov (NCT03097770) Treatment of Relapsed and/or Chemotherapy Refractory B-cell Malignancy by Tandem CAR T Cells Targeting CD19 and CD20 DM3M9OY RU https://clinicaltrials.gov/ct2/show/NCT03097770 DM3M9OY DI DM3M9OY DM3M9OY DN Anti-CD19/20-CAR vector-transduced T cells DM3M9OY MI TTUE541 DM3M9OY MN Leukocyte surface antigen Leu-16 (CD20) DM3M9OY MT DTT DM3M9OY MA CAR-T-Cell-Therapy(Dual specific) DM3M9OY RN ClinicalTrials.gov (NCT03097770) Treatment of Relapsed and/or Chemotherapy Refractory B-cell Malignancy by Tandem CAR T Cells Targeting CD19 and CD20 DM3M9OY RU https://clinicaltrials.gov/ct2/show/NCT03097770 DMGPTFL DI DMGPTFL DMGPTFL DN AZ-4217 DMGPTFL MI TT8JRS7 DMGPTFL MN Beta-secretase (BACE) DMGPTFL MT DTT DMGPTFL MA Inhibitor DMGPTFL RN AZ-4217: a high potency BACE inhibitor displaying acute central efficacy in different in vivo models and reduced amyloid deposition in Tg2576 mice. J Neurosci. 2013 Jun 12;33(24):10075-84. DMGPTFL RU https://pubmed.ncbi.nlm.nih.gov/23761903 DMCEPKM DI DMCEPKM DMCEPKM DN BCMA-CART DMCEPKM MI TTZ3P4W DMCEPKM MN B-cell maturation protein (TNFRSF17) DMCEPKM MT DTT DMCEPKM MA CAR-T-Cell-Therapy DMCEPKM RN ClinicalTrials.gov (NCT03492268) Safety and Efficacy Evaluation of BCMA-CART for Treating Multiple Myeloma DMCEPKM RU https://clinicaltrials.gov/ct2/show/NCT03492268 DMWXGRQ DI DMWXGRQ DMWXGRQ DN BCMA-UCART DMWXGRQ MI TTZ3P4W DMWXGRQ MN B-cell maturation protein (TNFRSF17) DMWXGRQ MT DTT DMWXGRQ MA CAR-T-Cell-Therapy DMWXGRQ RN ClinicalTrials.gov (NCT03752541) Efficacy and Safety Evaluation of BCMA-UCART DMWXGRQ RU https://clinicaltrials.gov/ct2/show/NCT03752541 DM531SA DI DM531SA DM531SA DN bimatoprost (free acid form) DM531SA MI TTT2ZAR DM531SA MN Prostaglandin F2-alpha receptor (PTGFR) DM531SA MT DTT DM531SA MA Agonist DM531SA RN Replacement of the carboxylic acid group of prostaglandin f(2alpha) with a hydroxyl or methoxy substituent provides biologically unique compounds. Br J Pharmacol. 2000 Aug;130(8):1933-43. DM531SA RU https://pubmed.ncbi.nlm.nih.gov/10952685 DMN2EI1 DI DMN2EI1 DMN2EI1 DN bis-triazole derivative 10 DMN2EI1 MI TTP86E2 DMN2EI1 MN Plasminogen (PLG) DMN2EI1 MT DTT DMN2EI1 MA Inhibitor DMN2EI1 RN A new strategy for the development of highly potent and selective plasmin inhibitors. J Med Chem. 2012 Feb 9;55(3):1171-80. DMN2EI1 RU https://pubmed.ncbi.nlm.nih.gov/22276953 DMLF2UY DI DMLF2UY DMLF2UY DN CAR-BCMA T cell DMLF2UY MI TTZ3P4W DMLF2UY MN B-cell maturation protein (TNFRSF17) DMLF2UY MT DTT DMLF2UY MA CAR-T-Cell-Therapy DMLF2UY RN ClinicalTrials.gov (NCT03302403) Clinical Study of Redirected Autologous T Cells With a Chimeric Antigen Receptor in Patients With Malignant Tumors DMLF2UY RU https://clinicaltrials.gov/ct2/show/NCT03302403 DMXU2D1 DI DMXU2D1 DMXU2D1 DN CAR-CD19 T cell DMXU2D1 MI TTW640A DMXU2D1 MN B-lymphocyte surface antigen B4 (CD19) DMXU2D1 MT DTT DMXU2D1 MA CAR-T-Cell-Therapy DMXU2D1 RN ClinicalTrials.gov (NCT03302403) Clinical Study of Redirected Autologous T Cells With a Chimeric Antigen Receptor in Patients With Malignant Tumors DMXU2D1 RU https://clinicaltrials.gov/ct2/show/NCT03302403 DM6ZHTV DI DM6ZHTV DM6ZHTV DN CAR-CLD18 T cell DM6ZHTV MI TT6PKBX DM6ZHTV MN Claudin-18 (CLDN18) DM6ZHTV MT DTT DM6ZHTV MA CAR-T-Cell-Therapy DM6ZHTV RN ClinicalTrials.gov (NCT03302403) Clinical Study of Redirected Autologous T Cells With a Chimeric Antigen Receptor in Patients With Malignant Tumors DM6ZHTV RU https://clinicaltrials.gov/ct2/show/NCT03302403 DMBDT3V DI DMBDT3V DMBDT3V DN CAR-GPC3 T cell DMBDT3V MI TTJTSX4 DMBDT3V MN Glypican-3 (GPC3) DMBDT3V MT DTT DMBDT3V MA CAR-T-Cell-Therapy DMBDT3V RN ClinicalTrials.gov (NCT03302403) Clinical Study of Redirected Autologous T Cells With a Chimeric Antigen Receptor in Patients With Malignant Tumors DMBDT3V RU https://clinicaltrials.gov/ct2/show/NCT03302403 DM0RX5E DI DM0RX5E DM0RX5E DN CAR-GPC3 T cells DM0RX5E MI TTJTSX4 DM0RX5E MN Glypican-3 (GPC3) DM0RX5E MT DTT DM0RX5E MA CAR-T-Cell-Therapy DM0RX5E RN ClinicalTrials.gov (NCT03146234) CAR-GPC3 T Cells in Patients With Refractory Hepatocellular Carcinoma DM0RX5E RU https://clinicaltrials.gov/ct2/show/NCT03146234 DMGW10M DI DMGW10M DMGW10M DN CAR-T cells targeting BCMA DMGW10M MI TTZ3P4W DMGW10M MN B-cell maturation protein (TNFRSF17) DMGW10M MT DTT DMGW10M MA CAR-T-Cell-Therapy DMGW10M RN ClinicalTrials.gov (NCT03473496) CAR-T Cells Therapy in Relapsed/Refractory Multiple Myeloma DMGW10M RU https://clinicaltrials.gov/ct2/show/NCT03473496 DMHBQYU DI DMHBQYU DMHBQYU DN CAR-T cells targeting CD138 DMHBQYU MI TTYDSVG DMHBQYU MN Syndecan-1 (SDC1) DMHBQYU MT DTT DMHBQYU MA CAR-T-Cell-Therapy DMHBQYU RN ClinicalTrials.gov (NCT03473496) CAR-T Cells Therapy in Relapsed/Refractory Multiple Myeloma DMHBQYU RU https://clinicaltrials.gov/ct2/show/NCT03473496 DMH5C37 DI DMH5C37 DMH5C37 DN CAR-T cells targeting CD38 DMH5C37 MI TTPURFN DMH5C37 MN Cyclic ADP-ribose hydrolase 1 (CD38) DMH5C37 MT DTT DMH5C37 MA CAR-T-Cell-Therapy DMH5C37 RN ClinicalTrials.gov (NCT03473457) CAR-T Cells Therapy in Relapsed/Refractory Acute Myeloid Leukemia DMH5C37 RU https://clinicaltrials.gov/ct2/show/NCT03473457 DMAK1ME DI DMAK1ME DMAK1ME DN CAR-T cells targeting CD56 DMAK1ME MI TTVXPHT DMAK1ME MN Neural cell adhesion molecule 1 (NCAM1) DMAK1ME MT DTT DMAK1ME MA CAR-T-Cell-Therapy DMAK1ME RN ClinicalTrials.gov (NCT03473457) CAR-T Cells Therapy in Relapsed/Refractory Acute Myeloid Leukemia DMAK1ME RU https://clinicaltrials.gov/ct2/show/NCT03473457 DMUEQ6C DI DMUEQ6C DMUEQ6C DN CART-meso cells DMUEQ6C MI TT4RXME DMUEQ6C MN Mesothelin (MSLN) DMUEQ6C MT DTT DMUEQ6C MA CAR-T-Cell-Therapy DMUEQ6C RN ClinicalTrials.gov (NCT03638193) Study of Autologous T-cells in Patients With Metastatic Pancreatic Cancer DMUEQ6C RU https://clinicaltrials.gov/ct2/show/NCT03638193 DM2V6R7 DI DM2V6R7 DM2V6R7 DN CD19-CAR T Cells DM2V6R7 MI TTW640A DM2V6R7 MN B-lymphocyte surface antigen B4 (CD19) DM2V6R7 MT DTT DM2V6R7 MA CAR-T-Cell-Therapy DM2V6R7 RN ClinicalTrials.gov (NCT03423706) Clinical Studies of New Model Haploidentical Hematopoietic Stem Cell Transplantation DM2V6R7 RU https://clinicaltrials.gov/ct2/show/NCT03423706 DMF936G DI DMF936G DMF936G DN CD19CART DMF936G MI TTW640A DMF936G MN B-lymphocyte surface antigen B4 (CD19) DMF936G MT DTT DMF936G MA CAR-T-Cell-Therapy DMF936G RN ClinicalTrials.gov (NCT02813837) Chimeric Antigen Receptor T Cells (CART) Therapy in Refractory/Relapsed B Cell Hematologic Malignancies DMF936G RU https://clinicaltrials.gov/ct2/show/NCT02813837 DMLPAFG DI DMLPAFG DMLPAFG DN CD19-targeted CAR-T cells DMLPAFG MI TTW640A DMLPAFG MN B-lymphocyte surface antigen B4 (CD19) DMLPAFG MT DTT DMLPAFG MA CAR-T-Cell-Therapy DMLPAFG RN ClinicalTrials.gov (NCT03564977) CD19-targeted CAR-T Cell Therapy for MRD+ B-cell Malignancies After Autologous Stem Cell Transplantation DMLPAFG RU https://clinicaltrials.gov/ct2/show/NCT03564977 DMS87UT DI DMS87UT DMS87UT DN CD19-targeted CAR-T cells DMS87UT MI TTW640A DMS87UT MN B-lymphocyte surface antigen B4 (CD19) DMS87UT MT DTT DMS87UT MA CAR-T-Cell-Therapy DMS87UT RN ClinicalTrials.gov (NCT02728882) Study Evaluating the Efficacy and Safety With CAR-T for Recurrent or Refractory Diffuse Large B Cell Lymphoma DMS87UT RU https://clinicaltrials.gov/ct2/show/NCT02728882 DM8VTF2 DI DM8VTF2 DM8VTF2 DN CD19-UCART DM8VTF2 MI TTW640A DM8VTF2 MN B-lymphocyte surface antigen B4 (CD19) DM8VTF2 MT DTT DM8VTF2 MA CAR-T-Cell-Therapy DM8VTF2 RN ClinicalTrials.gov (NCT03229876) Safety and Efficacy Evaluation of CD19-UCART DM8VTF2 RU https://clinicaltrials.gov/ct2/show/NCT03229876 DMXM19W DI DMXM19W DMXM19W DN dequalinium DMXM19W MI TT9R6BE DMXM19W MN Calcium-activated potassium channel KCa2.1 (KCNN1) DMXM19W MT DTT DMXM19W MA Blocker (channel blocker) DMXM19W RN Pharmacological characterization of small-conductance Ca(2+)-activated K(+) channels stably expressed in HEK 293 cells. Br J Pharmacol. 2000 Mar;129(5):991-9. DMXM19W RU https://pubmed.ncbi.nlm.nih.gov/10696100 DMXM19W DI DMXM19W DMXM19W DN dequalinium DMXM19W MI TT2T5M0 DMXM19W MN Calcium-activated potassium channel KCa2.2 (KCNN2) DMXM19W MT DTT DMXM19W MA Blocker (channel blocker) DMXM19W RN Block of rat brain recombinant SK channels by tricyclic antidepressants and related compounds. Eur J Pharmacol. 2000 Jul 28;401(1):1-7. DMXM19W RU https://pubmed.ncbi.nlm.nih.gov/10915830 DMXM19W DI DMXM19W DMXM19W DN dequalinium DMXM19W MI TT9JH25 DMXM19W MN Calcium-activated potassium channel KCa2.3 (KCNN3) DMXM19W MT DTT DMXM19W MA Blocker (channel blocker) DMXM19W RN Pharmacological characterisation of the human small conductance calcium-activated potassium channel hSK3 reveals sensitivity to tricyclic antidepressants and antipsychotic phenothiazines. Neuropharmacology. 2001 May;40(6):772-83. DMXM19W RU https://pubmed.ncbi.nlm.nih.gov/11369031 DMXM19W DI DMXM19W DMXM19W DN dequalinium DMXM19W MI TTHIQMC DMXM19W MN Cyclic nucleotide-gated channel alpha-1 (CNGA1) DMXM19W MT DTT DMXM19W MA Blocker (channel blocker) DMXM19W RN Dequalinium: a novel, high-affinity blocker of CNGA1 channels. J Gen Physiol. 2003 Jan;121(1):37-47. DMXM19W RU https://pubmed.ncbi.nlm.nih.gov/12508052 DMXM19W DI DMXM19W DMXM19W DN dequalinium DMXM19W MI TT8SJGB DMXM19W MN Cyclic nucleotide-gated channel alpha-2 (CNGA2) DMXM19W MT DTT DMXM19W MA Blocker (channel blocker) DMXM19W RN State-dependent block of CNG channels by dequalinium. J Gen Physiol. 2004 Mar;123(3):295-304. DMXM19W RU https://pubmed.ncbi.nlm.nih.gov/14981138 DMV6RMB DI DMV6RMB DMV6RMB DN EPCAM-targeted CAR-T cells DMV6RMB MI TTZ8WH4 DMV6RMB MN Tumor-associated calcium signal transducer 1 (EPCAM) DMV6RMB MT DTT DMV6RMB MA CAR-T-Cell-Therapy DMV6RMB RN ClinicalTrials.gov (NCT02725125) Study Evaluating the Efficacy and Safety With CAR-T for Stomach Cancer DMV6RMB RU https://clinicaltrials.gov/ct2/show/NCT02725125 DM2N653 DI DM2N653 DM2N653 DN example 98 (WO2011020806) DM2N653 MI TT69DB8 DM2N653 MN Beta-site APP-cleaving enzyme 2 (BACE2) DM2N653 MT DTT DM2N653 MA Inhibitor DM2N653 RN BACE2 as a new diabetes target: a patent review (2010 - 2012). Expert Opin Ther Pat. 2013 May;23(5):649-63. DM2N653 RU https://pubmed.ncbi.nlm.nih.gov/23506624 DM87BTM DI DM87BTM DM87BTM DN GD2-targeted CAR-T cells DM87BTM MI TT80ARU DM87BTM MN Ganglioside GD2 (GD2) DM87BTM MT DTT DM87BTM MA CAR-T-Cell-Therapy DM87BTM RN ClinicalTrials.gov (NCT02919046) Study Evaluating the Efficacy and Safety With CAR-T for Relapsed or Refractory Neuroblastoma in Children DM87BTM RU https://clinicaltrials.gov/ct2/show/NCT02919046 DM7W6YN DI DM7W6YN DM7W6YN DN GR148672X DM7W6YN MI TTMF541 DM7W6YN MN Liver carboxylesterase (CES1) DM7W6YN MT DTT DM7W6YN MA Inhibitor DM7W6YN RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2592). DM7W6YN RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2592 DMCV5ND DI DMCV5ND DMCV5ND DN GSK-264220A DMCV5ND MI TTHSZXO DMCV5ND MN Endothelial lipase (LIPG) DMCV5ND MT DTT DMCV5ND MA Inhibitor DMCV5ND RN Discovery of potent, selective sulfonylfuran urea endothelial lipase inhibitors. Bioorg Med Chem Lett. 2009 Jan 1;19(1):27-30. DMCV5ND RU https://pubmed.ncbi.nlm.nih.gov/19058966 DM5I2HL DI DM5I2HL DM5I2HL DN GSK269962A DM5I2HL MI TTZN7RP DM5I2HL MN Rho-associated protein kinase 1 (ROCK1) DM5I2HL MT DTT DM5I2HL MA Inhibitor DM5I2HL RN Novel Rho kinase inhibitors with anti-inflammatory and vasodilatory activities. J Pharmacol Exp Ther. 2007 Jan;320(1):89-98. DM5I2HL RU https://pubmed.ncbi.nlm.nih.gov/17018693 DM5I2HL DI DM5I2HL DM5I2HL DN GSK269962A DM5I2HL MI TTGWKQJ DM5I2HL MN Rho-associated protein kinase 2 (ROCK2) DM5I2HL MT DTT DM5I2HL MA Inhibitor DM5I2HL RN Novel Rho kinase inhibitors with anti-inflammatory and vasodilatory activities. J Pharmacol Exp Ther. 2007 Jan;320(1):89-98. DM5I2HL RU https://pubmed.ncbi.nlm.nih.gov/17018693 DM21Y8J DI DM21Y8J DM21Y8J DN isatin sulfonamide 34 DM21Y8J MI TTM7Y45 DM21Y8J MN Caspase-7 (CASP7) DM21Y8J MT DTT DM21Y8J MA Inhibitor DM21Y8J RN Potent and selective nonpeptide inhibitors of caspases 3 and 7. J Med Chem. 2001 Jun 7;44(12):2015-26. DM21Y8J RU https://pubmed.ncbi.nlm.nih.gov/11384246 DM21Y8J DI DM21Y8J DM21Y8J DN isatin sulfonamide 34 DM21Y8J MI TTB6T7O DM21Y8J MN Caspase-9 (CASP9) DM21Y8J MT DTT DM21Y8J MA Inhibitor DM21Y8J RN Potent and selective nonpeptide inhibitors of caspases 3 and 7. J Med Chem. 2001 Jun 7;44(12):2015-26. DM21Y8J RU https://pubmed.ncbi.nlm.nih.gov/11384246 DMDU6GN DI DMDU6GN DMDU6GN DN JNJ-479655 DMDU6GN MI TT473XN DMDU6GN MN P2X purinoceptor 7 (P2RX7) DMDU6GN MT DTT DMDU6GN MA Antagonist DMDU6GN RN Pharmacological characterization of a novel centrally permeable P2X7 receptor antagonist: JNJ-47965567. Br J Pharmacol. 2013 Oct;170(3):624-40. DMDU6GN RU https://pubmed.ncbi.nlm.nih.gov/23889535 DM2NZ6K DI DM2NZ6K DM2NZ6K DN KGP94 DM2NZ6K MI TT36ETB DM2NZ6K MN Cathepsin L (CTSL) DM2NZ6K MT DTT DM2NZ6K MA Inhibitor DM2NZ6K RN Functionalized benzophenone, thiophene, pyridine, and fluorene thiosemicarbazone derivatives as inhibitors of cathepsin L. Bioorg Med Chem Lett. 2010 Nov 15;20(22):6610-5. DM2NZ6K RU https://pubmed.ncbi.nlm.nih.gov/20933415 DMR1NYF DI DMR1NYF DMR1NYF DN KH064 DMR1NYF MI TTO8QRU DMR1NYF MN Group IIA phospholipase A2 (GIIA sPLA2) DMR1NYF MT DTT DMR1NYF MA Inhibitor DMR1NYF RN D-Tyrosine as a chiral precusor to potent inhibitors of human nonpancreatic secretory phospholipase A2 (IIa) with antiinflammatory activity. Chembiochem. 2003 Mar 3;4(2-3):181-5. DMR1NYF RU https://pubmed.ncbi.nlm.nih.gov/12616631 DMWA5XP DI DMWA5XP DMWA5XP DN KU-60019 DMWA5XP MI TTKBM7V DMWA5XP MN ATM serine/threonine kinase (ATM) DMWA5XP MT DTT DMWA5XP MA Inhibitor DMWA5XP RN Improved ATM kinase inhibitor KU-60019 radiosensitizes glioma cells, compromises insulin, AKT and ERK prosurvival signaling, and inhibits migration and invasion. Mol Cancer Ther. 2009 Oct;8(10):2894-902. DMWA5XP RU https://pubmed.ncbi.nlm.nih.gov/19808981 DMCMOS8 DI DMCMOS8 DMCMOS8 DN L-Cysteine DMCMOS8 MI DESYL1F DMCMOS8 MN Glutamate-cysteine ligase catalytic (GCLC) DMCMOS8 MT DME DMCMOS8 MA Metabolism DMCMOS8 RN The enzymes of glutathione synthesis: gamma-glutamylcysteine synthetase. Adv Enzymol Relat Areas Mol Biol. 1999;73:209-67, xii. DMCMOS8 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=10218110 DMCMOS8 DI DMCMOS8 DMCMOS8 DN L-Cysteine DMCMOS8 MI DEEBDFT DMCMOS8 MN Glutamate-cysteine ligase regulatory (GCLM) DMCMOS8 MT DME DMCMOS8 MA Metabolism DMCMOS8 RN The enzymes of glutathione synthesis: gamma-glutamylcysteine synthetase. Adv Enzymol Relat Areas Mol Biol. 1999;73:209-67, xii. DMCMOS8 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=10218110 DMW15TC DI DMW15TC DMW15TC DN methyl 5-[(4-tert-butylbenzoyl)amino]-2H-1,2,4-triazole-3-carboxylate DMW15TC MI TTRJSMV DMW15TC MN Factor XII messenger RNA (FA12 mRNA) DMW15TC MT DTT DMW15TC MA Inhibitor DMW15TC RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2361). DMW15TC RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2361 DMAPV6J DI DMAPV6J DMAPV6J DN MK-0249 DMAPV6J MI TT9JNIC DMAPV6J MN Histamine H3 receptor (H3R) DMAPV6J MT DTT DMAPV6J MA Agonist DMAPV6J RN Synthesis, structure-activity relationships, and biological profiles of a quinazolinone class of histamine H3 receptor inverse agonists. J Med Chem. 2008 Aug 14;51(15):4780-9. DMAPV6J RU https://pubmed.ncbi.nlm.nih.gov/18598020 DM3ADQW DI DM3ADQW DM3ADQW DN NIA-114 DM3ADQW MI TT8WFXV DM3ADQW MN Hydroxycarboxylic acid receptor 3 (HCAR3) DM3ADQW MT DTT DM3ADQW MA Agonist DM3ADQW RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DM3ADQW RU http://phrma-docs.phrma.org/files/dmfile/medicines-in-development-drug-list-autoimmune-diseases.pdf DM3ADQW DI DM3ADQW DM3ADQW DN NIA-114 DM3ADQW MI TTWNV8U DM3ADQW MN Nicotinic acid receptor (HCAR2) DM3ADQW MT DTT DM3ADQW MA Agonist DM3ADQW RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DM3ADQW RU http://phrma-docs.phrma.org/files/dmfile/medicines-in-development-drug-list-autoimmune-diseases.pdf DMXFI90 DI DMXFI90 DMXFI90 DN oxazine 89 DMXFI90 MI TT8JRS7 DMXFI90 MN Beta-secretase (BACE) DMXFI90 MT DTT DMXFI90 MA Inhibitor DMXFI90 RN beta-Secretase (BACE1) inhibitors with high in vivo efficacy suitable for clinical evaluation in Alzheimer's disease. J Med Chem. 2013 May 23;56(10):3980-95. DMXFI90 RU https://pubmed.ncbi.nlm.nih.gov/23590342 DMO0892 DI DMO0892 DMO0892 DN PF-4708671 DMO0892 MI TTG0U4H DMO0892 MN Ribosomal protein S6 kinase beta-1 (S6K1) DMO0892 MT DTT DMO0892 MA Inhibitor DMO0892 RN Characterization of PF-4708671, a novel and highly specific inhibitor of p70 ribosomal S6 kinase (S6K1). Biochem J. 2010 Oct 15;431(2):245-55. DMO0892 RU https://pubmed.ncbi.nlm.nih.gov/20704563 DM4XAU7 DI DM4XAU7 DM4XAU7 DN PGF2alpha DM4XAU7 MI DTCSGPB DM4XAU7 MN Multidrug resistance-associated protein 4 (ABCC4) DM4XAU7 MT DTP DM4XAU7 MA Substrate DM4XAU7 RN Human intestinal transporter database: QSAR modeling and virtual profiling of drug uptake, efflux and interactions. Pharm Res. 2013 Apr;30(4):996-1007. DM4XAU7 RU https://doi.org/10.1007/s11095-012-0935-x DM4XAU7 DI DM4XAU7 DM4XAU7 DN PGF2alpha DM4XAU7 MI DE9JFMC DM4XAU7 MN NADPH-dependent carbonyl reductase 1 (CBR1) DM4XAU7 MT DME DM4XAU7 MA Metabolism DM4XAU7 RN Metabolism of prostaglandins by the nonpregnant human uterus. J Clin Endocrinol Metab. 1983 Apr;56(4):678-85. DM4XAU7 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=6300160 DM4XAU7 DI DM4XAU7 DM4XAU7 DN PGF2alpha DM4XAU7 MI DTQ23VB DM4XAU7 MN Organic anion transporter 1 (SLC22A6) DM4XAU7 MT DTP DM4XAU7 MA Substrate DM4XAU7 RN Human organic anion transporters and human organic cation transporters mediate renal transport of prostaglandins. J Pharmacol Exp Ther. 2002 Apr;301(1):293-8. DM4XAU7 RU http://www.ncbi.nlm.nih.gov/pubmed/11907186 DM4XAU7 DI DM4XAU7 DM4XAU7 DN PGF2alpha DM4XAU7 MI DT0OC1Q DM4XAU7 MN Organic anion transporter 2 (SLC22A7) DM4XAU7 MT DTP DM4XAU7 MA Substrate DM4XAU7 RN Interaction of human organic anion transporters 2 and 4 with organic anion transport inhibitors. J Pharmacol Exp Ther. 2002 Jun;301(3):797-802. DM4XAU7 RU http://www.ncbi.nlm.nih.gov/pubmed/12023506 DM4XAU7 DI DM4XAU7 DM4XAU7 DN PGF2alpha DM4XAU7 MI DTVP67E DM4XAU7 MN Organic anion transporter 3 (SLC22A8) DM4XAU7 MT DTP DM4XAU7 MA Substrate DM4XAU7 RN Human organic anion transporters and human organic cation transporters mediate renal transport of prostaglandins. J Pharmacol Exp Ther. 2002 Apr;301(1):293-8. DM4XAU7 RU http://www.ncbi.nlm.nih.gov/pubmed/11907186 DM4XAU7 DI DM4XAU7 DM4XAU7 DN PGF2alpha DM4XAU7 MI DT06JWZ DM4XAU7 MN Organic anion transporter 4 (SLC22A11) DM4XAU7 MT DTP DM4XAU7 MA Substrate DM4XAU7 RN Human organic anion transporters and human organic cation transporters mediate renal transport of prostaglandins. J Pharmacol Exp Ther. 2002 Apr;301(1):293-8. DM4XAU7 RU http://www.ncbi.nlm.nih.gov/pubmed/11907186 DM4XAU7 DI DM4XAU7 DM4XAU7 DN PGF2alpha DM4XAU7 MI DT021JD DM4XAU7 MN Organic anion transporting polypeptide 2A1 (SLCO2A1) DM4XAU7 MT DTP DM4XAU7 MA Substrate DM4XAU7 RN Cloning, in vitro expression, and tissue distribution of a human prostaglandin transporter cDNA(hPGT). J Clin Invest. 1996 Sep 1;98(5):1142-9. DM4XAU7 RU http://www.ncbi.nlm.nih.gov/pubmed/8787677 DM4XAU7 DI DM4XAU7 DM4XAU7 DN PGF2alpha DM4XAU7 MI DTVNRXW DM4XAU7 MN Organic anion transporting polypeptide 3A1 (SLCO3A1) DM4XAU7 MT DTP DM4XAU7 MA Substrate DM4XAU7 RN Molecular characterization of human and rat organic anion transporter OATP-D. Am J Physiol Renal Physiol. 2003 Dec;285(6):F1188-97. DM4XAU7 RU http://www.ncbi.nlm.nih.gov/pubmed/14631946 DM4XAU7 DI DM4XAU7 DM4XAU7 DN PGF2alpha DM4XAU7 MI DTT79CX DM4XAU7 MN Organic cation transporter 1 (SLC22A1) DM4XAU7 MT DTP DM4XAU7 MA Substrate DM4XAU7 RN Human organic anion transporters and human organic cation transporters mediate renal transport of prostaglandins. J Pharmacol Exp Ther. 2002 Apr;301(1):293-8. DM4XAU7 RU http://www.ncbi.nlm.nih.gov/pubmed/11907186 DM4XAU7 DI DM4XAU7 DM4XAU7 DN PGF2alpha DM4XAU7 MI DT9IDPW DM4XAU7 MN Organic cation transporter 2 (SLC22A2) DM4XAU7 MT DTP DM4XAU7 MA Substrate DM4XAU7 RN Human organic anion transporters and human organic cation transporters mediate renal transport of prostaglandins. J Pharmacol Exp Ther. 2002 Apr;301(1):293-8. DM4XAU7 RU http://www.ncbi.nlm.nih.gov/pubmed/11907186 DM4XAU7 DI DM4XAU7 DM4XAU7 DN PGF2alpha DM4XAU7 MI TTNVEIR DM4XAU7 MN Prostaglandin D2 receptor (PTGDR) DM4XAU7 MT DTT DM4XAU7 MA Agonist DM4XAU7 RN The utilization of recombinant prostanoid receptors to determine the affinities and selectivities of prostaglandins and related analogs. Biochim Biophys Acta. 2000 Jan 17;1483(2):285-93. DM4XAU7 RU https://pubmed.ncbi.nlm.nih.gov/10634944 DM4XAU7 DI DM4XAU7 DM4XAU7 DN PGF2alpha DM4XAU7 MI TTQDMX5 DM4XAU7 MN Prostaglandin D2 receptor 2 (PTGDR2) DM4XAU7 MT DTT DM4XAU7 MA Agonist DM4XAU7 RN Expression and molecular pharmacology of the mouse CRTH2 receptor. J Pharmacol Exp Ther. 2003 Aug;306(2):463-70. DM4XAU7 RU https://pubmed.ncbi.nlm.nih.gov/12721327 DM4XAU7 DI DM4XAU7 DM4XAU7 DN PGF2alpha DM4XAU7 MI TTG1QMU DM4XAU7 MN Prostaglandin E2 receptor EP1 (PTGER1) DM4XAU7 MT DTT DM4XAU7 MA Agonist DM4XAU7 RN Molecular cloning and characterization of the four rat prostaglandin E2 prostanoid receptor subtypes. Eur J Pharmacol. 1997 Dec 11;340(2-3):227-41. DM4XAU7 RU https://pubmed.ncbi.nlm.nih.gov/9537820 DM4XAU7 DI DM4XAU7 DM4XAU7 DN PGF2alpha DM4XAU7 MI TT1ZAVI DM4XAU7 MN Prostaglandin E2 receptor EP2 (PTGER2) DM4XAU7 MT DTT DM4XAU7 MA Agonist DM4XAU7 RN Importance of the extracellular domain for prostaglandin EP(2) receptor function. Mol Pharmacol. 1999 Sep;56(3):545-51. DM4XAU7 RU https://pubmed.ncbi.nlm.nih.gov/10462542 DM4XAU7 DI DM4XAU7 DM4XAU7 DN PGF2alpha DM4XAU7 MI TTPNGDE DM4XAU7 MN Prostaglandin E2 receptor EP3 (PTGER3) DM4XAU7 MT DTT DM4XAU7 MA Agonist DM4XAU7 RN Ligand binding specificities of the eight types and subtypes of the mouse prostanoid receptors expressed in Chinese hamster ovary cells. Br J Pharmacol. 1997 Sep;122(2):217-24. DM4XAU7 RU https://pubmed.ncbi.nlm.nih.gov/9313928 DM4XAU7 DI DM4XAU7 DM4XAU7 DN PGF2alpha DM4XAU7 MI TT79WV3 DM4XAU7 MN Prostaglandin E2 receptor EP4 (PTGER4) DM4XAU7 MT DTT DM4XAU7 MA Agonist DM4XAU7 RN Molecular cloning and characterization of the four rat prostaglandin E2 prostanoid receptor subtypes. Eur J Pharmacol. 1997 Dec 11;340(2-3):227-41. DM4XAU7 RU https://pubmed.ncbi.nlm.nih.gov/9537820 DM4XAU7 DI DM4XAU7 DM4XAU7 DN PGF2alpha DM4XAU7 MI TTT2ZAR DM4XAU7 MN Prostaglandin F2-alpha receptor (PTGFR) DM4XAU7 MT DTT DM4XAU7 MA Agonist DM4XAU7 RN Identification by site-directed mutagenesis of amino acids contributing to ligand-binding specificity or signal transduction properties of the human FP prostanoid receptor. Biochem J. 2003 Apr 15;371(Pt 2):443-9. DM4XAU7 RU https://pubmed.ncbi.nlm.nih.gov/12519077 DM4XAU7 DI DM4XAU7 DM4XAU7 DN PGF2alpha DM4XAU7 MI TT2O84V DM4XAU7 MN Thromboxane A2 receptor (TBXA2R) DM4XAU7 MT DTT DM4XAU7 MA Agonist DM4XAU7 RN The utilization of recombinant prostanoid receptors to determine the affinities and selectivities of prostaglandins and related analogs. Biochim Biophys Acta. 2000 Jan 17;1483(2):285-93. DM4XAU7 RU https://pubmed.ncbi.nlm.nih.gov/10634944 DMXE0F2 DI DMXE0F2 DMXE0F2 DN PMID10498202C1 DMXE0F2 MI TTPT2QI DMXE0F2 MN Cathepsin D (CTSD) DMXE0F2 MT DTT DMXE0F2 MA Inhibitor DMXE0F2 RN Synthesis and structure activity relationships of novel small molecule cathepsin D inhibitors. Bioorg Med Chem Lett. 1999 Sep 6;9(17):2531-6. DMXE0F2 RU https://pubmed.ncbi.nlm.nih.gov/10498202 DMJGFLD DI DMJGFLD DMJGFLD DN PMID15026062C41 DMJGFLD MI TTLUQ8E DMJGFLD MN Hormone sensitive lipase (LIPE) DMJGFLD MT DTT DMJGFLD MA Inhibitor DMJGFLD RN Carbazates as potent inhibitors of hormone-sensitive lipase. Bioorg Med Chem Lett. 2004 Apr 5;14(7):1741-4. DMJGFLD RU https://pubmed.ncbi.nlm.nih.gov/15026062 DMO1IHL DI DMO1IHL DMO1IHL DN PMID17935984C1 DMO1IHL MI TTHY57M DMO1IHL MN Matrix metalloproteinase-13 (MMP-13) DMO1IHL MT DTT DMO1IHL MA Inhibitor DMO1IHL RN Potent, selective spiropyrrolidine pyrimidinetrione inhibitors of MMP-13. Bioorg Med Chem Lett. 2007 Dec 1;17(23):6529-34. DMO1IHL RU https://pubmed.ncbi.nlm.nih.gov/17935984 DMHPME3 DI DMHPME3 DMHPME3 DN PMID18163548C4 DMHPME3 MI TTGY7WI DMHPME3 MN Urokinase-type plasminogen activator (PLAU) DMHPME3 MT DTT DMHPME3 MA Inhibitor DMHPME3 RN Fragment-based discovery of mexiletine derivatives as orally bioavailable inhibitors of urokinase-type plasminogen activator. J Med Chem. 2008 Jan 24;51(2):183-6. DMHPME3 RU https://pubmed.ncbi.nlm.nih.gov/18163548 DM5UWH3 DI DM5UWH3 DM5UWH3 DN PMID22911925C2 DM5UWH3 MI TT8JRS7 DM5UWH3 MN Beta-secretase (BACE) DM5UWH3 MT DTT DM5UWH3 MA Inhibitor DM5UWH3 RN Establishing the relationship between in vitro potency, pharmacokinetic, and pharmacodynamic parameters in a series of orally available, hydroxyethylamine-derived beta-secretase inhibitors. J Pharmacol Exp Ther. 2012 Nov;343(2):460-7. DM5UWH3 RU https://pubmed.ncbi.nlm.nih.gov/22911925 DMX1IZ9 DI DMX1IZ9 DMX1IZ9 DN PMID23981898C11d DMX1IZ9 MI TT8JRS7 DMX1IZ9 MN Beta-secretase (BACE) DMX1IZ9 MT DTT DMX1IZ9 MA Inhibitor DMX1IZ9 RN Discovery of cyclic sulfoxide hydroxyethylamines as potent and selective beta-site APP-cleaving enzyme 1 (BACE1) inhibitors: structure based design and in vivo reduction of amyloid beta-peptides. Bioorg Med Chem Lett. 2013 Oct 1;23(19):5300-6. DMX1IZ9 RU https://pubmed.ncbi.nlm.nih.gov/23981898 DMCM5GK DI DMCM5GK DMCM5GK DN TAK-070 DMCM5GK MI TT8JRS7 DMCM5GK MN Beta-secretase (BACE) DMCM5GK MT DTT DMCM5GK MA Inhibitor DMCM5GK RN A noncompetitive BACE1 inhibitor TAK-070 ameliorates Abeta pathology and behavioral deficits in a mouse model of Alzheimer's disease. J Neurosci. 2010 Aug 18;30(33):11157-66. DMCM5GK RU https://pubmed.ncbi.nlm.nih.gov/20720123 DMGANIC DI DMGANIC DMGANIC DN tamatinib DMGANIC MI TT4DXQT DMGANIC MN Proto-oncogene c-Ret (RET) DMGANIC MT DTT DMGANIC MA Inhibitor DMGANIC RN Developmental toxicity associated with receptor tyrosine kinase Ret inhibition in reproductive toxicity testing. Birth Defects Res A Clin Mol Teratol. 2009 Feb;85(2):130-6. DMGANIC RU https://pubmed.ncbi.nlm.nih.gov/19107952 DMGANIC DI DMGANIC DMGANIC DN tamatinib DMGANIC MI TTOU65C DMGANIC MN Tyrosine-protein kinase SYK (SYK) DMGANIC MT DTT DMGANIC MA Inhibitor DMGANIC RN Pharmacophore modeling study based on known spleen tyrosine kinase inhibitors together with virtual screening for identifying novel inhibitors. Bioorg Med Chem Lett. 2009 Apr 1;19(7):1944-9. DMGANIC RU https://pubmed.ncbi.nlm.nih.gov/19254842 DMZO6CV DI DMZO6CV DMZO6CV DN tiratricol DMZO6CV MI TTTSEPU DMZO6CV MN Thyroid hormone receptor alpha (THRA) DMZO6CV MT DTT DMZO6CV MA Agonist DMZO6CV RN Binding of 3,5,3'-triiodothyronine (T3) and its analogs to the in vitro translational products of c-erbA protooncogenes: differences in the affinity of the alpha- and beta-forms for the acetic acid analog and failure of the human testis and kidney alpha-2 products to bind T3. Mol Endocrinol. 1990 Feb;4(2):227-34. DMZO6CV RU https://pubmed.ncbi.nlm.nih.gov/2158622 DMZO6CV DI DMZO6CV DMZO6CV DN tiratricol DMZO6CV MI TTGER3L DMZO6CV MN Thyroid hormone receptor beta (THRB) DMZO6CV MT DTT DMZO6CV MA Agonist DMZO6CV RN Binding of 3,5,3'-triiodothyronine (T3) and its analogs to the in vitro translational products of c-erbA protooncogenes: differences in the affinity of the alpha- and beta-forms for the acetic acid analog and failure of the human testis and kidney alpha-2 products to bind T3. Mol Endocrinol. 1990 Feb;4(2):227-34. DMZO6CV RU https://pubmed.ncbi.nlm.nih.gov/2158622 DMSRK2A DI DMSRK2A DMSRK2A DN UK-356202 DMSRK2A MI TTGY7WI DMSRK2A MN Urokinase-type plasminogen activator (PLAU) DMSRK2A MT DTT DMSRK2A MA Inhibitor DMSRK2A RN Selective urokinase-type plasminogen activator (uPA) inhibitors. Part 3: 1-isoquinolinylguanidines. Bioorg Med Chem Lett. 2004 Jun 21;14(12):3227-30. DMSRK2A RU https://pubmed.ncbi.nlm.nih.gov/15149680 DMOI0TN DI DMOI0TN DMOI0TN DN VU0364739 DMOI0TN MI TTRLMKF DMOI0TN MN Phospholipase D2 (PLD2) DMOI0TN MT DTT DMOI0TN MA Inhibitor DMOI0TN RN Design, synthesis, and biological evaluation of halogenated N-(2-(4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-8-yl)ethyl)benzamides: discovery of an isoform-selective small molecule phospholipase D2 inhibitor. J Med Chem. 2010 Sep 23;53(18):6706-19. DMOI0TN RU https://pubmed.ncbi.nlm.nih.gov/20735042 DMMLQAS DI DMMLQAS DMMLQAS DN (-)-deprenyl DMMLQAS MI TT32XQJ DMMLQAS MN Monoamine oxidase (MAO) DMMLQAS MT DTT DMMLQAS MA Inhibitor DMMLQAS RN Novel monoamine oxidase inhibitors: a patent review (2012 - 2014).Expert Opin Ther Pat. 2015 Jan;25(1):91-110. DMMLQAS RU https://www.ncbi.nlm.nih.gov/pubmed/25399762 DMGYZQ2 DI DMGYZQ2 DMGYZQ2 DN 1-(biphenyl-4-yl-methyl)-1H-imidazole derivative 1 DMGYZQ2 MI TTQVOEI DMGYZQ2 MN Angiotensin II receptor type-2 (AGTR2) DMGYZQ2 MT DTT DMGYZQ2 MA Agonist DMGYZQ2 RN PPAR ligands and their therapeutic applications: a patent review (2008 - 2014).Expert Opin Ther Pat. 2015 Feb;25(2):175-91. DMGYZQ2 RU https://www.ncbi.nlm.nih.gov/pubmed/25416646 DMGYZQ2 DI DMGYZQ2 DMGYZQ2 DN 1-(biphenyl-4-yl-methyl)-1H-imidazole derivative 1 DMGYZQ2 MI TTZMAO3 DMGYZQ2 MN Peroxisome proliferator-activated receptor gamma (PPAR-gamma) DMGYZQ2 MT DTT DMGYZQ2 MA Agonist DMGYZQ2 RN PPAR ligands and their therapeutic applications: a patent review (2008 - 2014).Expert Opin Ther Pat. 2015 Feb;25(2):175-91. DMGYZQ2 RU https://www.ncbi.nlm.nih.gov/pubmed/25416646 DMW5DC1 DI DMW5DC1 DMW5DC1 DN 1,2,3,4-tetrahydroisoquinoline derivative 1 DMW5DC1 MI TTGIZLN DMW5DC1 MN Keap1-Nrf2[dual DLG and ETGE] PPI (KEAP1-Nrf2 DLG and ETGE) DMW5DC1 MT DTT DMW5DC1 MA Modulator DMW5DC1 RN Recent progress in the development of small molecule Nrf2 modulators: a patent review (2012-2016).Expert Opin Ther Pat. 2017 Jul;27(7):763-785. DMW5DC1 RU https://www.ncbi.nlm.nih.gov/pubmed/28454500 DMW5DC1 DI DMW5DC1 DMW5DC1 DN 1,2,3,4-tetrahydroisoquinoline derivative 1 DMW5DC1 MI TTA6ZN2 DMW5DC1 MN Nuclear factor erythroid 2-related factor 2 (Nrf2) DMW5DC1 MT DTT DMW5DC1 MA Inhibitor DMW5DC1 RN Recent progress in the development of small molecule Nrf2 modulators: a patent review (2012-2016).Expert Opin Ther Pat. 2017 Jul;27(7):763-785. DMW5DC1 RU https://www.ncbi.nlm.nih.gov/pubmed/28454500 DMKHF39 DI DMKHF39 DMKHF39 DN 1,2,3-triazole derivative 1 DMKHF39 MI TT6OEDT DMKHF39 MN Cannabinoid receptor 1 (CB1) DMKHF39 MT DTT DMKHF39 MA Antagonist DMKHF39 RN A comprehensive patents review on cannabinoid 1 receptor antagonists as antiobesity agents. Expert Opin Ther Pat. 2015 Oct;25(10):1093-116. DMKHF39 RU https://pubmed.ncbi.nlm.nih.gov/26161824 DMFR23C DI DMFR23C DMFR23C DN 1,2,3-triazole derivative 2 DMFR23C MI TT6OEDT DMFR23C MN Cannabinoid receptor 1 (CB1) DMFR23C MT DTT DMFR23C MA Antagonist DMFR23C RN A comprehensive patents review on cannabinoid 1 receptor antagonists as antiobesity agents. Expert Opin Ther Pat. 2015 Oct;25(10):1093-116. DMFR23C RU https://pubmed.ncbi.nlm.nih.gov/26161824 DMLAYG7 DI DMLAYG7 DMLAYG7 DN 1,2,4,5-tetra-substituted imidazole derivative 1 DMLAYG7 MI TT6OEDT DMLAYG7 MN Cannabinoid receptor 1 (CB1) DMLAYG7 MT DTT DMLAYG7 MA Antagonist DMLAYG7 RN A comprehensive patents review on cannabinoid 1 receptor antagonists as antiobesity agents. Expert Opin Ther Pat. 2015 Oct;25(10):1093-116. DMLAYG7 RU https://pubmed.ncbi.nlm.nih.gov/26161824 DMMCYI5 DI DMMCYI5 DMMCYI5 DN 1,2,4,5-tetra-substituted imidazole derivative 2 DMMCYI5 MI TT6OEDT DMMCYI5 MN Cannabinoid receptor 1 (CB1) DMMCYI5 MT DTT DMMCYI5 MA Antagonist DMMCYI5 RN A comprehensive patents review on cannabinoid 1 receptor antagonists as antiobesity agents. Expert Opin Ther Pat. 2015 Oct;25(10):1093-116. DMMCYI5 RU https://pubmed.ncbi.nlm.nih.gov/26161824 DMESOA8 DI DMESOA8 DMESOA8 DN 1,2,4-oxadiazole derivative 1 DMESOA8 MI TTNBFWK DMESOA8 MN Programmed cell death protein 1 (PD-1) DMESOA8 MT DTT DMESOA8 MA Inhibitor DMESOA8 RN A patent review on PD-1/PD-L1 antagonists: small molecules, peptides, and macrocycles (2015-2018).Expert Opin Ther Pat. 2018 Sep;28(9):665-678. DMESOA8 RU https://www.ncbi.nlm.nih.gov/pubmed/30107136 DMA42SB DI DMA42SB DMA42SB DN 1,2,4-oxadiazole derivative 2 DMA42SB MI TTNBFWK DMA42SB MN Programmed cell death protein 1 (PD-1) DMA42SB MT DTT DMA42SB MA Inhibitor DMA42SB RN A patent review on PD-1/PD-L1 antagonists: small molecules, peptides, and macrocycles (2015-2018).Expert Opin Ther Pat. 2018 Sep;28(9):665-678. DMA42SB RU https://www.ncbi.nlm.nih.gov/pubmed/30107136 DMT6EDP DI DMT6EDP DMT6EDP DN 1,2,4-oxadiazole derivative 4 DMT6EDP MI TT23XQV DMT6EDP MN PD-1-PD-L1 interaction (PD-1/PD-L1 PPI) DMT6EDP MT DTT DMT6EDP MA Inhibitor DMT6EDP RN A patent review on PD-1/PD-L1 antagonists: small molecules, peptides, and macrocycles (2015-2018).Expert Opin Ther Pat. 2018 Sep;28(9):665-678. DMT6EDP RU https://www.ncbi.nlm.nih.gov/pubmed/30107136 DM683R7 DI DM683R7 DM683R7 DN 1,2,4-oxadiazole derivative 5 DM683R7 MI TT23XQV DM683R7 MN PD-1-PD-L1 interaction (PD-1/PD-L1 PPI) DM683R7 MT DTT DM683R7 MA Inhibitor DM683R7 RN A patent review on PD-1/PD-L1 antagonists: small molecules, peptides, and macrocycles (2015-2018).Expert Opin Ther Pat. 2018 Sep;28(9):665-678. DM683R7 RU https://www.ncbi.nlm.nih.gov/pubmed/30107136 DMFYKBJ DI DMFYKBJ DMFYKBJ DN 1,2,4-oxadiazole derivative 6 DMFYKBJ MI TT23XQV DMFYKBJ MN PD-1-PD-L1 interaction (PD-1/PD-L1 PPI) DMFYKBJ MT DTT DMFYKBJ MA Inhibitor DMFYKBJ RN A patent review on PD-1/PD-L1 antagonists: small molecules, peptides, and macrocycles (2015-2018).Expert Opin Ther Pat. 2018 Sep;28(9):665-678. DMFYKBJ RU https://www.ncbi.nlm.nih.gov/pubmed/30107136 DMBT4RJ DI DMBT4RJ DMBT4RJ DN 1,2,4-oxadiazole derivative 7 DMBT4RJ MI TT23XQV DMBT4RJ MN PD-1-PD-L1 interaction (PD-1/PD-L1 PPI) DMBT4RJ MT DTT DMBT4RJ MA Inhibitor DMBT4RJ RN A patent review on PD-1/PD-L1 antagonists: small molecules, peptides, and macrocycles (2015-2018).Expert Opin Ther Pat. 2018 Sep;28(9):665-678. DMBT4RJ RU https://www.ncbi.nlm.nih.gov/pubmed/30107136 DMQF62D DI DMQF62D DMQF62D DN 1,2,4-triazole [1,5-a]pyrimidin-7-yl derivative 1 DMQF62D MI TTJGW1Z DMQF62D MN Phosphodiesterase 2A (PDE2A) DMQF62D MT DTT DMQF62D MA Inhibitor DMQF62D RN Towards selective phosphodiesterase 2A (PDE2A) inhibitors: a patent review (2010 - present).Expert Opin Ther Pat. 2016 Aug;26(8):933-46. DMQF62D RU https://www.ncbi.nlm.nih.gov/pubmed/27321640 DM8KWQ9 DI DM8KWQ9 DM8KWQ9 DN 1,2,4-triazole [1,5-a]pyrimidin-7-yl derivative 2 DM8KWQ9 MI TTJGW1Z DM8KWQ9 MN Phosphodiesterase 2A (PDE2A) DM8KWQ9 MT DTT DM8KWQ9 MA Inhibitor DM8KWQ9 RN Towards selective phosphodiesterase 2A (PDE2A) inhibitors: a patent review (2010 - present).Expert Opin Ther Pat. 2016 Aug;26(8):933-46. DM8KWQ9 RU https://www.ncbi.nlm.nih.gov/pubmed/27321640 DMR1QP4 DI DMR1QP4 DMR1QP4 DN 1,2,4-triazole [1,5-a]pyrimidin-7-yl derivative 3 DMR1QP4 MI TTJGW1Z DMR1QP4 MN Phosphodiesterase 2A (PDE2A) DMR1QP4 MT DTT DMR1QP4 MA Inhibitor DMR1QP4 RN Towards selective phosphodiesterase 2A (PDE2A) inhibitors: a patent review (2010 - present).Expert Opin Ther Pat. 2016 Aug;26(8):933-46. DMR1QP4 RU https://www.ncbi.nlm.nih.gov/pubmed/27321640 DMD9QW2 DI DMD9QW2 DMD9QW2 DN 1,2,4-triazole [4,3-a]quinoxaline derivative 1 DMD9QW2 MI TTJW4LU DMD9QW2 MN Phosphodiesterase 10A (PDE10) DMD9QW2 MT DTT DMD9QW2 MA Inhibitor DMD9QW2 RN Towards selective phosphodiesterase 2A (PDE2A) inhibitors: a patent review (2010 - present).Expert Opin Ther Pat. 2016 Aug;26(8):933-46. DMD9QW2 RU https://www.ncbi.nlm.nih.gov/pubmed/27321640 DMD9QW2 DI DMD9QW2 DMD9QW2 DN 1,2,4-triazole [4,3-a]quinoxaline derivative 1 DMD9QW2 MI TTJGW1Z DMD9QW2 MN Phosphodiesterase 2A (PDE2A) DMD9QW2 MT DTT DMD9QW2 MA Inhibitor DMD9QW2 RN Towards selective phosphodiesterase 2A (PDE2A) inhibitors: a patent review (2010 - present).Expert Opin Ther Pat. 2016 Aug;26(8):933-46. DMD9QW2 RU https://www.ncbi.nlm.nih.gov/pubmed/27321640 DM3DIW9 DI DM3DIW9 DM3DIW9 DN 1,2,4-triazole [4,3-a]quinoxaline derivative 2 DM3DIW9 MI TTJW4LU DM3DIW9 MN Phosphodiesterase 10A (PDE10) DM3DIW9 MT DTT DM3DIW9 MA Inhibitor DM3DIW9 RN Towards selective phosphodiesterase 2A (PDE2A) inhibitors: a patent review (2010 - present).Expert Opin Ther Pat. 2016 Aug;26(8):933-46. DM3DIW9 RU https://www.ncbi.nlm.nih.gov/pubmed/27321640 DM3DIW9 DI DM3DIW9 DM3DIW9 DN 1,2,4-triazole [4,3-a]quinoxaline derivative 2 DM3DIW9 MI TTJGW1Z DM3DIW9 MN Phosphodiesterase 2A (PDE2A) DM3DIW9 MT DTT DM3DIW9 MA Inhibitor DM3DIW9 RN Towards selective phosphodiesterase 2A (PDE2A) inhibitors: a patent review (2010 - present).Expert Opin Ther Pat. 2016 Aug;26(8):933-46. DM3DIW9 RU https://www.ncbi.nlm.nih.gov/pubmed/27321640 DMKXRYM DI DMKXRYM DMKXRYM DN 1,2,4-triazole [4,3-a]quinoxaline derivative 3 DMKXRYM MI TTJW4LU DMKXRYM MN Phosphodiesterase 10A (PDE10) DMKXRYM MT DTT DMKXRYM MA Inhibitor DMKXRYM RN Towards selective phosphodiesterase 2A (PDE2A) inhibitors: a patent review (2010 - present).Expert Opin Ther Pat. 2016 Aug;26(8):933-46. DMKXRYM RU https://www.ncbi.nlm.nih.gov/pubmed/27321640 DMKXRYM DI DMKXRYM DMKXRYM DN 1,2,4-triazole [4,3-a]quinoxaline derivative 3 DMKXRYM MI TTJGW1Z DMKXRYM MN Phosphodiesterase 2A (PDE2A) DMKXRYM MT DTT DMKXRYM MA Inhibitor DMKXRYM RN Towards selective phosphodiesterase 2A (PDE2A) inhibitors: a patent review (2010 - present).Expert Opin Ther Pat. 2016 Aug;26(8):933-46. DMKXRYM RU https://www.ncbi.nlm.nih.gov/pubmed/27321640 DME8MN1 DI DME8MN1 DME8MN1 DN 1,2,4-triazole derivative 1 DME8MN1 MI TT6OEDT DME8MN1 MN Cannabinoid receptor 1 (CB1) DME8MN1 MT DTT DME8MN1 MA Antagonist DME8MN1 RN A comprehensive patents review on cannabinoid 1 receptor antagonists as antiobesity agents. Expert Opin Ther Pat. 2015 Oct;25(10):1093-116. DME8MN1 RU https://pubmed.ncbi.nlm.nih.gov/26161824 DM91Z8B DI DM91Z8B DM91Z8B DN 1,2,4-triazole derivative 2 DM91Z8B MI TT6OEDT DM91Z8B MN Cannabinoid receptor 1 (CB1) DM91Z8B MT DTT DM91Z8B MA Antagonist DM91Z8B RN A comprehensive patents review on cannabinoid 1 receptor antagonists as antiobesity agents. Expert Opin Ther Pat. 2015 Oct;25(10):1093-116. DM91Z8B RU https://pubmed.ncbi.nlm.nih.gov/26161824 DMU9XMV DI DMU9XMV DMU9XMV DN 1,2,4-triazole derivative 3 DMU9XMV MI TT5TPI6 DMU9XMV MN Opioid receptor sigma 1 (OPRS1) DMU9XMV MT DTT DMU9XMV MA Inhibitor DMU9XMV RN Are sigma modulators an effective opportunity for cancer treatment A patent overview (1996-2016).Expert Opin Ther Pat. 2017 May;27(5):565-578. DMU9XMV RU https://www.ncbi.nlm.nih.gov/pubmed/28051882 DMHBJFN DI DMHBJFN DMHBJFN DN 1,2,4-triazole derivative 4 DMHBJFN MI TT5TPI6 DMHBJFN MN Opioid receptor sigma 1 (OPRS1) DMHBJFN MT DTT DMHBJFN MA Inhibitor DMHBJFN RN Are sigma modulators an effective opportunity for cancer treatment A patent overview (1996-2016).Expert Opin Ther Pat. 2017 May;27(5):565-578. DMHBJFN RU https://www.ncbi.nlm.nih.gov/pubmed/28051882 DMIUPSA DI DMIUPSA DMIUPSA DN 1,2,4-triazolo[1,5a]pyridine derivative 1 DMIUPSA MI TTON5IT DMIUPSA MN Focal adhesion kinase 1 (FAK) DMIUPSA MT DTT DMIUPSA MA Inhibitor DMIUPSA RN Inhibitors of JAK-family kinases: an update on the patent literature 2013-2015, part 1.Expert Opin Ther Pat. 2017 Feb;27(2):127-143. DMIUPSA RU https://www.ncbi.nlm.nih.gov/pubmed/27774824 DMIUPSA DI DMIUPSA DMIUPSA DN 1,2,4-triazolo[1,5a]pyridine derivative 1 DMIUPSA MI TTRMX3V DMIUPSA MN Janus kinase 2 (JAK-2) DMIUPSA MT DTT DMIUPSA MA Inhibitor DMIUPSA RN Inhibitors of JAK-family kinases: an update on the patent literature 2013-2015, part 1.Expert Opin Ther Pat. 2017 Feb;27(2):127-143. DMIUPSA RU https://www.ncbi.nlm.nih.gov/pubmed/27774824 DMIUPSA DI DMIUPSA DMIUPSA DN 1,2,4-triazolo[1,5a]pyridine derivative 1 DMIUPSA MI TTT7PJU DMIUPSA MN Janus kinase 3 (JAK-3) DMIUPSA MT DTT DMIUPSA MA Inhibitor DMIUPSA RN Inhibitors of JAK-family kinases: an update on the patent literature 2013-2015, part 1.Expert Opin Ther Pat. 2017 Feb;27(2):127-143. DMIUPSA RU https://www.ncbi.nlm.nih.gov/pubmed/27774824 DMZFILT DI DMZFILT DMZFILT DN 1,2,4-triazolo[1,5a]pyridine derivative 2 DMZFILT MI TTPMQSO DMZFILT MN ALK tyrosine kinase receptor (ALK) DMZFILT MT DTT DMZFILT MA Inhibitor DMZFILT RN Inhibitors of JAK-family kinases: an update on the patent literature 2013-2015, part 1.Expert Opin Ther Pat. 2017 Feb;27(2):127-143. DMZFILT RU https://www.ncbi.nlm.nih.gov/pubmed/27774824 DMZFILT DI DMZFILT DMZFILT DN 1,2,4-triazolo[1,5a]pyridine derivative 2 DMZFILT MI TTRMX3V DMZFILT MN Janus kinase 2 (JAK-2) DMZFILT MT DTT DMZFILT MA Inhibitor DMZFILT RN Inhibitors of JAK-family kinases: an update on the patent literature 2013-2015, part 1.Expert Opin Ther Pat. 2017 Feb;27(2):127-143. DMZFILT RU https://www.ncbi.nlm.nih.gov/pubmed/27774824 DMMNVZ5 DI DMMNVZ5 DMMNVZ5 DN 1,2,4-tri-substituted imidazoline derivative 1 DMMNVZ5 MI TT6OEDT DMMNVZ5 MN Cannabinoid receptor 1 (CB1) DMMNVZ5 MT DTT DMMNVZ5 MA Antagonist DMMNVZ5 RN A comprehensive patents review on cannabinoid 1 receptor antagonists as antiobesity agents. Expert Opin Ther Pat. 2015 Oct;25(10):1093-116. DMMNVZ5 RU https://pubmed.ncbi.nlm.nih.gov/26161824 DMNH8GW DI DMNH8GW DMNH8GW DN 1,2-diamino cyclopentane-based derivative 1 DMNH8GW MI TT60Q8D DMNH8GW MN Orexin receptor type 1 (HCRTR1) DMNH8GW MT DTT DMNH8GW MA Antagonist DMNH8GW RN Substituted cyclopentanes, tetrahydrofurans and pyrrolidines as orexin-1-receptor antagonists for treatment of various CNS disorders (WO2015/055994; WO2015/124932; WO2015/124934).Expert Opin Ther Pat. 2016;26(3):409-15. DMNH8GW RU https://www.ncbi.nlm.nih.gov/pubmed/26593218 DMNH8GW DI DMNH8GW DMNH8GW DN 1,2-diamino cyclopentane-based derivative 1 DMNH8GW MI TT9N02I DMNH8GW MN Orexin receptor type 2 (HCRTR2) DMNH8GW MT DTT DMNH8GW MA Antagonist DMNH8GW RN Substituted cyclopentanes, tetrahydrofurans and pyrrolidines as orexin-1-receptor antagonists for treatment of various CNS disorders (WO2015/055994; WO2015/124932; WO2015/124934).Expert Opin Ther Pat. 2016;26(3):409-15. DMNH8GW RU https://www.ncbi.nlm.nih.gov/pubmed/26593218 DM3ZF95 DI DM3ZF95 DM3ZF95 DN 1,2-diamino cyclopentane-based derivative 10 DM3ZF95 MI TT60Q8D DM3ZF95 MN Orexin receptor type 1 (HCRTR1) DM3ZF95 MT DTT DM3ZF95 MA Antagonist DM3ZF95 RN Substituted cyclopentanes, tetrahydrofurans and pyrrolidines as orexin-1-receptor antagonists for treatment of various CNS disorders (WO2015/055994; WO2015/124932; WO2015/124934).Expert Opin Ther Pat. 2016;26(3):409-15. DM3ZF95 RU https://www.ncbi.nlm.nih.gov/pubmed/26593218 DM3ZF95 DI DM3ZF95 DM3ZF95 DN 1,2-diamino cyclopentane-based derivative 10 DM3ZF95 MI TT9N02I DM3ZF95 MN Orexin receptor type 2 (HCRTR2) DM3ZF95 MT DTT DM3ZF95 MA Antagonist DM3ZF95 RN Substituted cyclopentanes, tetrahydrofurans and pyrrolidines as orexin-1-receptor antagonists for treatment of various CNS disorders (WO2015/055994; WO2015/124932; WO2015/124934).Expert Opin Ther Pat. 2016;26(3):409-15. DM3ZF95 RU https://www.ncbi.nlm.nih.gov/pubmed/26593218 DMPZECW DI DMPZECW DMPZECW DN 1,2-diamino cyclopentane-based derivative 11 DMPZECW MI TT60Q8D DMPZECW MN Orexin receptor type 1 (HCRTR1) DMPZECW MT DTT DMPZECW MA Antagonist DMPZECW RN Substituted cyclopentanes, tetrahydrofurans and pyrrolidines as orexin-1-receptor antagonists for treatment of various CNS disorders (WO2015/055994; WO2015/124932; WO2015/124934).Expert Opin Ther Pat. 2016;26(3):409-15. DMPZECW RU https://www.ncbi.nlm.nih.gov/pubmed/26593218 DMPZECW DI DMPZECW DMPZECW DN 1,2-diamino cyclopentane-based derivative 11 DMPZECW MI TT9N02I DMPZECW MN Orexin receptor type 2 (HCRTR2) DMPZECW MT DTT DMPZECW MA Antagonist DMPZECW RN Substituted cyclopentanes, tetrahydrofurans and pyrrolidines as orexin-1-receptor antagonists for treatment of various CNS disorders (WO2015/055994; WO2015/124932; WO2015/124934).Expert Opin Ther Pat. 2016;26(3):409-15. DMPZECW RU https://www.ncbi.nlm.nih.gov/pubmed/26593218 DMWV53X DI DMWV53X DMWV53X DN 1,2-diamino cyclopentane-based derivative 12 DMWV53X MI TT60Q8D DMWV53X MN Orexin receptor type 1 (HCRTR1) DMWV53X MT DTT DMWV53X MA Antagonist DMWV53X RN Substituted cyclopentanes, tetrahydrofurans and pyrrolidines as orexin-1-receptor antagonists for treatment of various CNS disorders (WO2015/055994; WO2015/124932; WO2015/124934).Expert Opin Ther Pat. 2016;26(3):409-15. DMWV53X RU https://www.ncbi.nlm.nih.gov/pubmed/26593218 DMWV53X DI DMWV53X DMWV53X DN 1,2-diamino cyclopentane-based derivative 12 DMWV53X MI TT9N02I DMWV53X MN Orexin receptor type 2 (HCRTR2) DMWV53X MT DTT DMWV53X MA Antagonist DMWV53X RN Substituted cyclopentanes, tetrahydrofurans and pyrrolidines as orexin-1-receptor antagonists for treatment of various CNS disorders (WO2015/055994; WO2015/124932; WO2015/124934).Expert Opin Ther Pat. 2016;26(3):409-15. DMWV53X RU https://www.ncbi.nlm.nih.gov/pubmed/26593218 DM10UX4 DI DM10UX4 DM10UX4 DN 1,2-diamino cyclopentane-based derivative 13 DM10UX4 MI TT60Q8D DM10UX4 MN Orexin receptor type 1 (HCRTR1) DM10UX4 MT DTT DM10UX4 MA Antagonist DM10UX4 RN Substituted cyclopentanes, tetrahydrofurans and pyrrolidines as orexin-1-receptor antagonists for treatment of various CNS disorders (WO2015/055994; WO2015/124932; WO2015/124934).Expert Opin Ther Pat. 2016;26(3):409-15. DM10UX4 RU https://www.ncbi.nlm.nih.gov/pubmed/26593218 DM10UX4 DI DM10UX4 DM10UX4 DN 1,2-diamino cyclopentane-based derivative 13 DM10UX4 MI TT9N02I DM10UX4 MN Orexin receptor type 2 (HCRTR2) DM10UX4 MT DTT DM10UX4 MA Antagonist DM10UX4 RN Substituted cyclopentanes, tetrahydrofurans and pyrrolidines as orexin-1-receptor antagonists for treatment of various CNS disorders (WO2015/055994; WO2015/124932; WO2015/124934).Expert Opin Ther Pat. 2016;26(3):409-15. DM10UX4 RU https://www.ncbi.nlm.nih.gov/pubmed/26593218 DMTZDUV DI DMTZDUV DMTZDUV DN 1,2-diamino cyclopentane-based derivative 14 DMTZDUV MI TT60Q8D DMTZDUV MN Orexin receptor type 1 (HCRTR1) DMTZDUV MT DTT DMTZDUV MA Antagonist DMTZDUV RN Substituted cyclopentanes, tetrahydrofurans and pyrrolidines as orexin-1-receptor antagonists for treatment of various CNS disorders (WO2015/055994; WO2015/124932; WO2015/124934).Expert Opin Ther Pat. 2016;26(3):409-15. DMTZDUV RU https://www.ncbi.nlm.nih.gov/pubmed/26593218 DMTZDUV DI DMTZDUV DMTZDUV DN 1,2-diamino cyclopentane-based derivative 14 DMTZDUV MI TT9N02I DMTZDUV MN Orexin receptor type 2 (HCRTR2) DMTZDUV MT DTT DMTZDUV MA Antagonist DMTZDUV RN Substituted cyclopentanes, tetrahydrofurans and pyrrolidines as orexin-1-receptor antagonists for treatment of various CNS disorders (WO2015/055994; WO2015/124932; WO2015/124934).Expert Opin Ther Pat. 2016;26(3):409-15. DMTZDUV RU https://www.ncbi.nlm.nih.gov/pubmed/26593218 DMBY65W DI DMBY65W DMBY65W DN 1,2-diamino cyclopentane-based derivative 15 DMBY65W MI TT60Q8D DMBY65W MN Orexin receptor type 1 (HCRTR1) DMBY65W MT DTT DMBY65W MA Antagonist DMBY65W RN Substituted cyclopentanes, tetrahydrofurans and pyrrolidines as orexin-1-receptor antagonists for treatment of various CNS disorders (WO2015/055994; WO2015/124932; WO2015/124934).Expert Opin Ther Pat. 2016;26(3):409-15. DMBY65W RU https://www.ncbi.nlm.nih.gov/pubmed/26593218 DMBY65W DI DMBY65W DMBY65W DN 1,2-diamino cyclopentane-based derivative 15 DMBY65W MI TT9N02I DMBY65W MN Orexin receptor type 2 (HCRTR2) DMBY65W MT DTT DMBY65W MA Antagonist DMBY65W RN Substituted cyclopentanes, tetrahydrofurans and pyrrolidines as orexin-1-receptor antagonists for treatment of various CNS disorders (WO2015/055994; WO2015/124932; WO2015/124934).Expert Opin Ther Pat. 2016;26(3):409-15. DMBY65W RU https://www.ncbi.nlm.nih.gov/pubmed/26593218 DMHEX1Q DI DMHEX1Q DMHEX1Q DN 1,2-diamino cyclopentane-based derivative 16 DMHEX1Q MI TT60Q8D DMHEX1Q MN Orexin receptor type 1 (HCRTR1) DMHEX1Q MT DTT DMHEX1Q MA Antagonist DMHEX1Q RN Substituted cyclopentanes, tetrahydrofurans and pyrrolidines as orexin-1-receptor antagonists for treatment of various CNS disorders (WO2015/055994; WO2015/124932; WO2015/124934).Expert Opin Ther Pat. 2016;26(3):409-15. DMHEX1Q RU https://www.ncbi.nlm.nih.gov/pubmed/26593218 DMHEX1Q DI DMHEX1Q DMHEX1Q DN 1,2-diamino cyclopentane-based derivative 16 DMHEX1Q MI TT9N02I DMHEX1Q MN Orexin receptor type 2 (HCRTR2) DMHEX1Q MT DTT DMHEX1Q MA Antagonist DMHEX1Q RN Substituted cyclopentanes, tetrahydrofurans and pyrrolidines as orexin-1-receptor antagonists for treatment of various CNS disorders (WO2015/055994; WO2015/124932; WO2015/124934).Expert Opin Ther Pat. 2016;26(3):409-15. DMHEX1Q RU https://www.ncbi.nlm.nih.gov/pubmed/26593218 DMBC9UK DI DMBC9UK DMBC9UK DN 1,2-diamino cyclopentane-based derivative 17 DMBC9UK MI TT60Q8D DMBC9UK MN Orexin receptor type 1 (HCRTR1) DMBC9UK MT DTT DMBC9UK MA Antagonist DMBC9UK RN Substituted cyclopentanes, tetrahydrofurans and pyrrolidines as orexin-1-receptor antagonists for treatment of various CNS disorders (WO2015/055994; WO2015/124932; WO2015/124934).Expert Opin Ther Pat. 2016;26(3):409-15. DMBC9UK RU https://www.ncbi.nlm.nih.gov/pubmed/26593218 DMBC9UK DI DMBC9UK DMBC9UK DN 1,2-diamino cyclopentane-based derivative 17 DMBC9UK MI TT9N02I DMBC9UK MN Orexin receptor type 2 (HCRTR2) DMBC9UK MT DTT DMBC9UK MA Antagonist DMBC9UK RN Substituted cyclopentanes, tetrahydrofurans and pyrrolidines as orexin-1-receptor antagonists for treatment of various CNS disorders (WO2015/055994; WO2015/124932; WO2015/124934).Expert Opin Ther Pat. 2016;26(3):409-15. DMBC9UK RU https://www.ncbi.nlm.nih.gov/pubmed/26593218 DMCNQAF DI DMCNQAF DMCNQAF DN 1,2-diamino cyclopentane-based derivative 18 DMCNQAF MI TT60Q8D DMCNQAF MN Orexin receptor type 1 (HCRTR1) DMCNQAF MT DTT DMCNQAF MA Antagonist DMCNQAF RN Substituted cyclopentanes, tetrahydrofurans and pyrrolidines as orexin-1-receptor antagonists for treatment of various CNS disorders (WO2015/055994; WO2015/124932; WO2015/124934).Expert Opin Ther Pat. 2016;26(3):409-15. DMCNQAF RU https://www.ncbi.nlm.nih.gov/pubmed/26593218 DMCNQAF DI DMCNQAF DMCNQAF DN 1,2-diamino cyclopentane-based derivative 18 DMCNQAF MI TT9N02I DMCNQAF MN Orexin receptor type 2 (HCRTR2) DMCNQAF MT DTT DMCNQAF MA Antagonist DMCNQAF RN Substituted cyclopentanes, tetrahydrofurans and pyrrolidines as orexin-1-receptor antagonists for treatment of various CNS disorders (WO2015/055994; WO2015/124932; WO2015/124934).Expert Opin Ther Pat. 2016;26(3):409-15. DMCNQAF RU https://www.ncbi.nlm.nih.gov/pubmed/26593218 DMCBPI4 DI DMCBPI4 DMCBPI4 DN 1,2-diamino cyclopentane-based derivative 19 DMCBPI4 MI TT60Q8D DMCBPI4 MN Orexin receptor type 1 (HCRTR1) DMCBPI4 MT DTT DMCBPI4 MA Antagonist DMCBPI4 RN Substituted cyclopentanes, tetrahydrofurans and pyrrolidines as orexin-1-receptor antagonists for treatment of various CNS disorders (WO2015/055994; WO2015/124932; WO2015/124934).Expert Opin Ther Pat. 2016;26(3):409-15. DMCBPI4 RU https://www.ncbi.nlm.nih.gov/pubmed/26593218 DMCBPI4 DI DMCBPI4 DMCBPI4 DN 1,2-diamino cyclopentane-based derivative 19 DMCBPI4 MI TT9N02I DMCBPI4 MN Orexin receptor type 2 (HCRTR2) DMCBPI4 MT DTT DMCBPI4 MA Antagonist DMCBPI4 RN Substituted cyclopentanes, tetrahydrofurans and pyrrolidines as orexin-1-receptor antagonists for treatment of various CNS disorders (WO2015/055994; WO2015/124932; WO2015/124934).Expert Opin Ther Pat. 2016;26(3):409-15. DMCBPI4 RU https://www.ncbi.nlm.nih.gov/pubmed/26593218 DM7RG5I DI DM7RG5I DM7RG5I DN 1,2-diamino cyclopentane-based derivative 2 DM7RG5I MI TT60Q8D DM7RG5I MN Orexin receptor type 1 (HCRTR1) DM7RG5I MT DTT DM7RG5I MA Antagonist DM7RG5I RN Substituted cyclopentanes, tetrahydrofurans and pyrrolidines as orexin-1-receptor antagonists for treatment of various CNS disorders (WO2015/055994; WO2015/124932; WO2015/124934).Expert Opin Ther Pat. 2016;26(3):409-15. DM7RG5I RU https://www.ncbi.nlm.nih.gov/pubmed/26593218 DM7RG5I DI DM7RG5I DM7RG5I DN 1,2-diamino cyclopentane-based derivative 2 DM7RG5I MI TT9N02I DM7RG5I MN Orexin receptor type 2 (HCRTR2) DM7RG5I MT DTT DM7RG5I MA Antagonist DM7RG5I RN Substituted cyclopentanes, tetrahydrofurans and pyrrolidines as orexin-1-receptor antagonists for treatment of various CNS disorders (WO2015/055994; WO2015/124932; WO2015/124934).Expert Opin Ther Pat. 2016;26(3):409-15. DM7RG5I RU https://www.ncbi.nlm.nih.gov/pubmed/26593218 DM9PHIK DI DM9PHIK DM9PHIK DN 1,2-diamino cyclopentane-based derivative 20 DM9PHIK MI TT60Q8D DM9PHIK MN Orexin receptor type 1 (HCRTR1) DM9PHIK MT DTT DM9PHIK MA Antagonist DM9PHIK RN Substituted cyclopentanes, tetrahydrofurans and pyrrolidines as orexin-1-receptor antagonists for treatment of various CNS disorders (WO2015/055994; WO2015/124932; WO2015/124934).Expert Opin Ther Pat. 2016;26(3):409-15. DM9PHIK RU https://www.ncbi.nlm.nih.gov/pubmed/26593218 DM9PHIK DI DM9PHIK DM9PHIK DN 1,2-diamino cyclopentane-based derivative 20 DM9PHIK MI TT9N02I DM9PHIK MN Orexin receptor type 2 (HCRTR2) DM9PHIK MT DTT DM9PHIK MA Antagonist DM9PHIK RN Substituted cyclopentanes, tetrahydrofurans and pyrrolidines as orexin-1-receptor antagonists for treatment of various CNS disorders (WO2015/055994; WO2015/124932; WO2015/124934).Expert Opin Ther Pat. 2016;26(3):409-15. DM9PHIK RU https://www.ncbi.nlm.nih.gov/pubmed/26593218 DM5Y1DC DI DM5Y1DC DM5Y1DC DN 1,2-diamino cyclopentane-based derivative 21 DM5Y1DC MI TT60Q8D DM5Y1DC MN Orexin receptor type 1 (HCRTR1) DM5Y1DC MT DTT DM5Y1DC MA Antagonist DM5Y1DC RN Substituted cyclopentanes, tetrahydrofurans and pyrrolidines as orexin-1-receptor antagonists for treatment of various CNS disorders (WO2015/055994; WO2015/124932; WO2015/124934).Expert Opin Ther Pat. 2016;26(3):409-15. DM5Y1DC RU https://www.ncbi.nlm.nih.gov/pubmed/26593218 DM5Y1DC DI DM5Y1DC DM5Y1DC DN 1,2-diamino cyclopentane-based derivative 21 DM5Y1DC MI TT9N02I DM5Y1DC MN Orexin receptor type 2 (HCRTR2) DM5Y1DC MT DTT DM5Y1DC MA Antagonist DM5Y1DC RN Substituted cyclopentanes, tetrahydrofurans and pyrrolidines as orexin-1-receptor antagonists for treatment of various CNS disorders (WO2015/055994; WO2015/124932; WO2015/124934).Expert Opin Ther Pat. 2016;26(3):409-15. DM5Y1DC RU https://www.ncbi.nlm.nih.gov/pubmed/26593218 DMXRLI6 DI DMXRLI6 DMXRLI6 DN 1,2-diamino cyclopentane-based derivative 22 DMXRLI6 MI TT60Q8D DMXRLI6 MN Orexin receptor type 1 (HCRTR1) DMXRLI6 MT DTT DMXRLI6 MA Antagonist DMXRLI6 RN Substituted cyclopentanes, tetrahydrofurans and pyrrolidines as orexin-1-receptor antagonists for treatment of various CNS disorders (WO2015/055994; WO2015/124932; WO2015/124934).Expert Opin Ther Pat. 2016;26(3):409-15. DMXRLI6 RU https://www.ncbi.nlm.nih.gov/pubmed/26593218 DMXRLI6 DI DMXRLI6 DMXRLI6 DN 1,2-diamino cyclopentane-based derivative 22 DMXRLI6 MI TT9N02I DMXRLI6 MN Orexin receptor type 2 (HCRTR2) DMXRLI6 MT DTT DMXRLI6 MA Antagonist DMXRLI6 RN Substituted cyclopentanes, tetrahydrofurans and pyrrolidines as orexin-1-receptor antagonists for treatment of various CNS disorders (WO2015/055994; WO2015/124932; WO2015/124934).Expert Opin Ther Pat. 2016;26(3):409-15. DMXRLI6 RU https://www.ncbi.nlm.nih.gov/pubmed/26593218 DM0HIQU DI DM0HIQU DM0HIQU DN 1,2-diamino cyclopentane-based derivative 23 DM0HIQU MI TT60Q8D DM0HIQU MN Orexin receptor type 1 (HCRTR1) DM0HIQU MT DTT DM0HIQU MA Antagonist DM0HIQU RN Substituted cyclopentanes, tetrahydrofurans and pyrrolidines as orexin-1-receptor antagonists for treatment of various CNS disorders (WO2015/055994; WO2015/124932; WO2015/124934).Expert Opin Ther Pat. 2016;26(3):409-15. DM0HIQU RU https://www.ncbi.nlm.nih.gov/pubmed/26593218 DM0HIQU DI DM0HIQU DM0HIQU DN 1,2-diamino cyclopentane-based derivative 23 DM0HIQU MI TT9N02I DM0HIQU MN Orexin receptor type 2 (HCRTR2) DM0HIQU MT DTT DM0HIQU MA Antagonist DM0HIQU RN Substituted cyclopentanes, tetrahydrofurans and pyrrolidines as orexin-1-receptor antagonists for treatment of various CNS disorders (WO2015/055994; WO2015/124932; WO2015/124934).Expert Opin Ther Pat. 2016;26(3):409-15. DM0HIQU RU https://www.ncbi.nlm.nih.gov/pubmed/26593218 DMC26MT DI DMC26MT DMC26MT DN 1,2-diamino cyclopentane-based derivative 24 DMC26MT MI TT60Q8D DMC26MT MN Orexin receptor type 1 (HCRTR1) DMC26MT MT DTT DMC26MT MA Antagonist DMC26MT RN Substituted cyclopentanes, tetrahydrofurans and pyrrolidines as orexin-1-receptor antagonists for treatment of various CNS disorders (WO2015/055994; WO2015/124932; WO2015/124934).Expert Opin Ther Pat. 2016;26(3):409-15. DMC26MT RU https://www.ncbi.nlm.nih.gov/pubmed/26593218 DMC26MT DI DMC26MT DMC26MT DN 1,2-diamino cyclopentane-based derivative 24 DMC26MT MI TT9N02I DMC26MT MN Orexin receptor type 2 (HCRTR2) DMC26MT MT DTT DMC26MT MA Antagonist DMC26MT RN Substituted cyclopentanes, tetrahydrofurans and pyrrolidines as orexin-1-receptor antagonists for treatment of various CNS disorders (WO2015/055994; WO2015/124932; WO2015/124934).Expert Opin Ther Pat. 2016;26(3):409-15. DMC26MT RU https://www.ncbi.nlm.nih.gov/pubmed/26593218 DMEW0AT DI DMEW0AT DMEW0AT DN 1,2-diamino cyclopentane-based derivative 25 DMEW0AT MI TT60Q8D DMEW0AT MN Orexin receptor type 1 (HCRTR1) DMEW0AT MT DTT DMEW0AT MA Antagonist DMEW0AT RN Substituted cyclopentanes, tetrahydrofurans and pyrrolidines as orexin-1-receptor antagonists for treatment of various CNS disorders (WO2015/055994; WO2015/124932; WO2015/124934).Expert Opin Ther Pat. 2016;26(3):409-15. DMEW0AT RU https://www.ncbi.nlm.nih.gov/pubmed/26593218 DMEW0AT DI DMEW0AT DMEW0AT DN 1,2-diamino cyclopentane-based derivative 25 DMEW0AT MI TT9N02I DMEW0AT MN Orexin receptor type 2 (HCRTR2) DMEW0AT MT DTT DMEW0AT MA Antagonist DMEW0AT RN Substituted cyclopentanes, tetrahydrofurans and pyrrolidines as orexin-1-receptor antagonists for treatment of various CNS disorders (WO2015/055994; WO2015/124932; WO2015/124934).Expert Opin Ther Pat. 2016;26(3):409-15. DMEW0AT RU https://www.ncbi.nlm.nih.gov/pubmed/26593218 DMTFG4J DI DMTFG4J DMTFG4J DN 1,2-diamino cyclopentane-based derivative 26 DMTFG4J MI TT60Q8D DMTFG4J MN Orexin receptor type 1 (HCRTR1) DMTFG4J MT DTT DMTFG4J MA Antagonist DMTFG4J RN Substituted cyclopentanes, tetrahydrofurans and pyrrolidines as orexin-1-receptor antagonists for treatment of various CNS disorders (WO2015/055994; WO2015/124932; WO2015/124934).Expert Opin Ther Pat. 2016;26(3):409-15. DMTFG4J RU https://www.ncbi.nlm.nih.gov/pubmed/26593218 DMTFG4J DI DMTFG4J DMTFG4J DN 1,2-diamino cyclopentane-based derivative 26 DMTFG4J MI TT9N02I DMTFG4J MN Orexin receptor type 2 (HCRTR2) DMTFG4J MT DTT DMTFG4J MA Antagonist DMTFG4J RN Substituted cyclopentanes, tetrahydrofurans and pyrrolidines as orexin-1-receptor antagonists for treatment of various CNS disorders (WO2015/055994; WO2015/124932; WO2015/124934).Expert Opin Ther Pat. 2016;26(3):409-15. DMTFG4J RU https://www.ncbi.nlm.nih.gov/pubmed/26593218 DM5LQJW DI DM5LQJW DM5LQJW DN 1,2-diamino cyclopentane-based derivative 27 DM5LQJW MI TT60Q8D DM5LQJW MN Orexin receptor type 1 (HCRTR1) DM5LQJW MT DTT DM5LQJW MA Antagonist DM5LQJW RN Substituted cyclopentanes, tetrahydrofurans and pyrrolidines as orexin-1-receptor antagonists for treatment of various CNS disorders (WO2015/055994; WO2015/124932; WO2015/124934).Expert Opin Ther Pat. 2016;26(3):409-15. DM5LQJW RU https://www.ncbi.nlm.nih.gov/pubmed/26593218 DM5LQJW DI DM5LQJW DM5LQJW DN 1,2-diamino cyclopentane-based derivative 27 DM5LQJW MI TT9N02I DM5LQJW MN Orexin receptor type 2 (HCRTR2) DM5LQJW MT DTT DM5LQJW MA Antagonist DM5LQJW RN Substituted cyclopentanes, tetrahydrofurans and pyrrolidines as orexin-1-receptor antagonists for treatment of various CNS disorders (WO2015/055994; WO2015/124932; WO2015/124934).Expert Opin Ther Pat. 2016;26(3):409-15. DM5LQJW RU https://www.ncbi.nlm.nih.gov/pubmed/26593218 DMUTF17 DI DMUTF17 DMUTF17 DN 1,2-diamino cyclopentane-based derivative 28 DMUTF17 MI TT9BPT3 DMUTF17 MN Orexin receptor (HCRTR) DMUTF17 MT DTT DMUTF17 MA Antagonist DMUTF17 RN Substituted cyclopentanes, tetrahydrofurans and pyrrolidines as orexin-1-receptor antagonists for treatment of various CNS disorders (WO2015/055994; WO2015/124932; WO2015/124934).Expert Opin Ther Pat. 2016;26(3):409-15. DMUTF17 RU https://www.ncbi.nlm.nih.gov/pubmed/26593218 DM5FVH0 DI DM5FVH0 DM5FVH0 DN 1,2-diamino cyclopentane-based derivative 29 DM5FVH0 MI TT60Q8D DM5FVH0 MN Orexin receptor type 1 (HCRTR1) DM5FVH0 MT DTT DM5FVH0 MA Antagonist DM5FVH0 RN Substituted cyclopentanes, tetrahydrofurans and pyrrolidines as orexin-1-receptor antagonists for treatment of various CNS disorders (WO2015/055994; WO2015/124932; WO2015/124934).Expert Opin Ther Pat. 2016;26(3):409-15. DM5FVH0 RU https://www.ncbi.nlm.nih.gov/pubmed/26593218 DM5FVH0 DI DM5FVH0 DM5FVH0 DN 1,2-diamino cyclopentane-based derivative 29 DM5FVH0 MI TT9N02I DM5FVH0 MN Orexin receptor type 2 (HCRTR2) DM5FVH0 MT DTT DM5FVH0 MA Antagonist DM5FVH0 RN Substituted cyclopentanes, tetrahydrofurans and pyrrolidines as orexin-1-receptor antagonists for treatment of various CNS disorders (WO2015/055994; WO2015/124932; WO2015/124934).Expert Opin Ther Pat. 2016;26(3):409-15. DM5FVH0 RU https://www.ncbi.nlm.nih.gov/pubmed/26593218 DM143OK DI DM143OK DM143OK DN 1,2-diamino cyclopentane-based derivative 3 DM143OK MI TT60Q8D DM143OK MN Orexin receptor type 1 (HCRTR1) DM143OK MT DTT DM143OK MA Antagonist DM143OK RN Substituted cyclopentanes, tetrahydrofurans and pyrrolidines as orexin-1-receptor antagonists for treatment of various CNS disorders (WO2015/055994; WO2015/124932; WO2015/124934).Expert Opin Ther Pat. 2016;26(3):409-15. DM143OK RU https://www.ncbi.nlm.nih.gov/pubmed/26593218 DM143OK DI DM143OK DM143OK DN 1,2-diamino cyclopentane-based derivative 3 DM143OK MI TT9N02I DM143OK MN Orexin receptor type 2 (HCRTR2) DM143OK MT DTT DM143OK MA Antagonist DM143OK RN Substituted cyclopentanes, tetrahydrofurans and pyrrolidines as orexin-1-receptor antagonists for treatment of various CNS disorders (WO2015/055994; WO2015/124932; WO2015/124934).Expert Opin Ther Pat. 2016;26(3):409-15. DM143OK RU https://www.ncbi.nlm.nih.gov/pubmed/26593218 DMZ4NJQ DI DMZ4NJQ DMZ4NJQ DN 1,2-diamino cyclopentane-based derivative 30 DMZ4NJQ MI TT60Q8D DMZ4NJQ MN Orexin receptor type 1 (HCRTR1) DMZ4NJQ MT DTT DMZ4NJQ MA Antagonist DMZ4NJQ RN Substituted cyclopentanes, tetrahydrofurans and pyrrolidines as orexin-1-receptor antagonists for treatment of various CNS disorders (WO2015/055994; WO2015/124932; WO2015/124934).Expert Opin Ther Pat. 2016;26(3):409-15. DMZ4NJQ RU https://www.ncbi.nlm.nih.gov/pubmed/26593218 DMZ4NJQ DI DMZ4NJQ DMZ4NJQ DN 1,2-diamino cyclopentane-based derivative 30 DMZ4NJQ MI TT9N02I DMZ4NJQ MN Orexin receptor type 2 (HCRTR2) DMZ4NJQ MT DTT DMZ4NJQ MA Antagonist DMZ4NJQ RN Substituted cyclopentanes, tetrahydrofurans and pyrrolidines as orexin-1-receptor antagonists for treatment of various CNS disorders (WO2015/055994; WO2015/124932; WO2015/124934).Expert Opin Ther Pat. 2016;26(3):409-15. DMZ4NJQ RU https://www.ncbi.nlm.nih.gov/pubmed/26593218 DMVZ5EP DI DMVZ5EP DMVZ5EP DN 1,2-diamino cyclopentane-based derivative 31 DMVZ5EP MI TT60Q8D DMVZ5EP MN Orexin receptor type 1 (HCRTR1) DMVZ5EP MT DTT DMVZ5EP MA Antagonist DMVZ5EP RN Substituted cyclopentanes, tetrahydrofurans and pyrrolidines as orexin-1-receptor antagonists for treatment of various CNS disorders (WO2015/055994; WO2015/124932; WO2015/124934).Expert Opin Ther Pat. 2016;26(3):409-15. DMVZ5EP RU https://www.ncbi.nlm.nih.gov/pubmed/26593218 DMVZ5EP DI DMVZ5EP DMVZ5EP DN 1,2-diamino cyclopentane-based derivative 31 DMVZ5EP MI TT9N02I DMVZ5EP MN Orexin receptor type 2 (HCRTR2) DMVZ5EP MT DTT DMVZ5EP MA Antagonist DMVZ5EP RN Substituted cyclopentanes, tetrahydrofurans and pyrrolidines as orexin-1-receptor antagonists for treatment of various CNS disorders (WO2015/055994; WO2015/124932; WO2015/124934).Expert Opin Ther Pat. 2016;26(3):409-15. DMVZ5EP RU https://www.ncbi.nlm.nih.gov/pubmed/26593218 DMQX8SD DI DMQX8SD DMQX8SD DN 1,2-diamino cyclopentane-based derivative 32 DMQX8SD MI TT60Q8D DMQX8SD MN Orexin receptor type 1 (HCRTR1) DMQX8SD MT DTT DMQX8SD MA Antagonist DMQX8SD RN Substituted cyclopentanes, tetrahydrofurans and pyrrolidines as orexin-1-receptor antagonists for treatment of various CNS disorders (WO2015/055994; WO2015/124932; WO2015/124934).Expert Opin Ther Pat. 2016;26(3):409-15. DMQX8SD RU https://www.ncbi.nlm.nih.gov/pubmed/26593218 DMQX8SD DI DMQX8SD DMQX8SD DN 1,2-diamino cyclopentane-based derivative 32 DMQX8SD MI TT9N02I DMQX8SD MN Orexin receptor type 2 (HCRTR2) DMQX8SD MT DTT DMQX8SD MA Antagonist DMQX8SD RN Substituted cyclopentanes, tetrahydrofurans and pyrrolidines as orexin-1-receptor antagonists for treatment of various CNS disorders (WO2015/055994; WO2015/124932; WO2015/124934).Expert Opin Ther Pat. 2016;26(3):409-15. DMQX8SD RU https://www.ncbi.nlm.nih.gov/pubmed/26593218 DMBOLSU DI DMBOLSU DMBOLSU DN 1,2-diamino cyclopentane-based derivative 33 DMBOLSU MI TT60Q8D DMBOLSU MN Orexin receptor type 1 (HCRTR1) DMBOLSU MT DTT DMBOLSU MA Antagonist DMBOLSU RN Substituted cyclopentanes, tetrahydrofurans and pyrrolidines as orexin-1-receptor antagonists for treatment of various CNS disorders (WO2015/055994; WO2015/124932; WO2015/124934).Expert Opin Ther Pat. 2016;26(3):409-15. DMBOLSU RU https://www.ncbi.nlm.nih.gov/pubmed/26593218 DMBOLSU DI DMBOLSU DMBOLSU DN 1,2-diamino cyclopentane-based derivative 33 DMBOLSU MI TT9N02I DMBOLSU MN Orexin receptor type 2 (HCRTR2) DMBOLSU MT DTT DMBOLSU MA Antagonist DMBOLSU RN Substituted cyclopentanes, tetrahydrofurans and pyrrolidines as orexin-1-receptor antagonists for treatment of various CNS disorders (WO2015/055994; WO2015/124932; WO2015/124934).Expert Opin Ther Pat. 2016;26(3):409-15. DMBOLSU RU https://www.ncbi.nlm.nih.gov/pubmed/26593218 DMVHL3W DI DMVHL3W DMVHL3W DN 1,2-diamino cyclopentane-based derivative 34 DMVHL3W MI TT60Q8D DMVHL3W MN Orexin receptor type 1 (HCRTR1) DMVHL3W MT DTT DMVHL3W MA Antagonist DMVHL3W RN Substituted cyclopentanes, tetrahydrofurans and pyrrolidines as orexin-1-receptor antagonists for treatment of various CNS disorders (WO2015/055994; WO2015/124932; WO2015/124934).Expert Opin Ther Pat. 2016;26(3):409-15. DMVHL3W RU https://www.ncbi.nlm.nih.gov/pubmed/26593218 DMVHL3W DI DMVHL3W DMVHL3W DN 1,2-diamino cyclopentane-based derivative 34 DMVHL3W MI TT9N02I DMVHL3W MN Orexin receptor type 2 (HCRTR2) DMVHL3W MT DTT DMVHL3W MA Antagonist DMVHL3W RN Substituted cyclopentanes, tetrahydrofurans and pyrrolidines as orexin-1-receptor antagonists for treatment of various CNS disorders (WO2015/055994; WO2015/124932; WO2015/124934).Expert Opin Ther Pat. 2016;26(3):409-15. DMVHL3W RU https://www.ncbi.nlm.nih.gov/pubmed/26593218 DMFBPSX DI DMFBPSX DMFBPSX DN 1,2-diamino cyclopentane-based derivative 4 DMFBPSX MI TT60Q8D DMFBPSX MN Orexin receptor type 1 (HCRTR1) DMFBPSX MT DTT DMFBPSX MA Antagonist DMFBPSX RN Substituted cyclopentanes, tetrahydrofurans and pyrrolidines as orexin-1-receptor antagonists for treatment of various CNS disorders (WO2015/055994; WO2015/124932; WO2015/124934).Expert Opin Ther Pat. 2016;26(3):409-15. DMFBPSX RU https://www.ncbi.nlm.nih.gov/pubmed/26593218 DMFBPSX DI DMFBPSX DMFBPSX DN 1,2-diamino cyclopentane-based derivative 4 DMFBPSX MI TT9N02I DMFBPSX MN Orexin receptor type 2 (HCRTR2) DMFBPSX MT DTT DMFBPSX MA Antagonist DMFBPSX RN Substituted cyclopentanes, tetrahydrofurans and pyrrolidines as orexin-1-receptor antagonists for treatment of various CNS disorders (WO2015/055994; WO2015/124932; WO2015/124934).Expert Opin Ther Pat. 2016;26(3):409-15. DMFBPSX RU https://www.ncbi.nlm.nih.gov/pubmed/26593218 DMCP15K DI DMCP15K DMCP15K DN 1,2-diamino cyclopentane-based derivative 5 DMCP15K MI TT60Q8D DMCP15K MN Orexin receptor type 1 (HCRTR1) DMCP15K MT DTT DMCP15K MA Antagonist DMCP15K RN Substituted cyclopentanes, tetrahydrofurans and pyrrolidines as orexin-1-receptor antagonists for treatment of various CNS disorders (WO2015/055994; WO2015/124932; WO2015/124934).Expert Opin Ther Pat. 2016;26(3):409-15. DMCP15K RU https://www.ncbi.nlm.nih.gov/pubmed/26593218 DMCP15K DI DMCP15K DMCP15K DN 1,2-diamino cyclopentane-based derivative 5 DMCP15K MI TT9N02I DMCP15K MN Orexin receptor type 2 (HCRTR2) DMCP15K MT DTT DMCP15K MA Antagonist DMCP15K RN Substituted cyclopentanes, tetrahydrofurans and pyrrolidines as orexin-1-receptor antagonists for treatment of various CNS disorders (WO2015/055994; WO2015/124932; WO2015/124934).Expert Opin Ther Pat. 2016;26(3):409-15. DMCP15K RU https://www.ncbi.nlm.nih.gov/pubmed/26593218 DMJ4ACP DI DMJ4ACP DMJ4ACP DN 1,2-diamino cyclopentane-based derivative 6 DMJ4ACP MI TT60Q8D DMJ4ACP MN Orexin receptor type 1 (HCRTR1) DMJ4ACP MT DTT DMJ4ACP MA Antagonist DMJ4ACP RN Substituted cyclopentanes, tetrahydrofurans and pyrrolidines as orexin-1-receptor antagonists for treatment of various CNS disorders (WO2015/055994; WO2015/124932; WO2015/124934).Expert Opin Ther Pat. 2016;26(3):409-15. DMJ4ACP RU https://www.ncbi.nlm.nih.gov/pubmed/26593218 DMJ4ACP DI DMJ4ACP DMJ4ACP DN 1,2-diamino cyclopentane-based derivative 6 DMJ4ACP MI TT9N02I DMJ4ACP MN Orexin receptor type 2 (HCRTR2) DMJ4ACP MT DTT DMJ4ACP MA Antagonist DMJ4ACP RN Substituted cyclopentanes, tetrahydrofurans and pyrrolidines as orexin-1-receptor antagonists for treatment of various CNS disorders (WO2015/055994; WO2015/124932; WO2015/124934).Expert Opin Ther Pat. 2016;26(3):409-15. DMJ4ACP RU https://www.ncbi.nlm.nih.gov/pubmed/26593218 DMHIV24 DI DMHIV24 DMHIV24 DN 1,2-diamino cyclopentane-based derivative 7 DMHIV24 MI TT60Q8D DMHIV24 MN Orexin receptor type 1 (HCRTR1) DMHIV24 MT DTT DMHIV24 MA Antagonist DMHIV24 RN Substituted cyclopentanes, tetrahydrofurans and pyrrolidines as orexin-1-receptor antagonists for treatment of various CNS disorders (WO2015/055994; WO2015/124932; WO2015/124934).Expert Opin Ther Pat. 2016;26(3):409-15. DMHIV24 RU https://www.ncbi.nlm.nih.gov/pubmed/26593218 DMHIV24 DI DMHIV24 DMHIV24 DN 1,2-diamino cyclopentane-based derivative 7 DMHIV24 MI TT9N02I DMHIV24 MN Orexin receptor type 2 (HCRTR2) DMHIV24 MT DTT DMHIV24 MA Antagonist DMHIV24 RN Substituted cyclopentanes, tetrahydrofurans and pyrrolidines as orexin-1-receptor antagonists for treatment of various CNS disorders (WO2015/055994; WO2015/124932; WO2015/124934).Expert Opin Ther Pat. 2016;26(3):409-15. DMHIV24 RU https://www.ncbi.nlm.nih.gov/pubmed/26593218 DM7JX8U DI DM7JX8U DM7JX8U DN 1,2-diamino cyclopentane-based derivative 8 DM7JX8U MI TT60Q8D DM7JX8U MN Orexin receptor type 1 (HCRTR1) DM7JX8U MT DTT DM7JX8U MA Antagonist DM7JX8U RN Substituted cyclopentanes, tetrahydrofurans and pyrrolidines as orexin-1-receptor antagonists for treatment of various CNS disorders (WO2015/055994; WO2015/124932; WO2015/124934).Expert Opin Ther Pat. 2016;26(3):409-15. DM7JX8U RU https://www.ncbi.nlm.nih.gov/pubmed/26593218 DM7JX8U DI DM7JX8U DM7JX8U DN 1,2-diamino cyclopentane-based derivative 8 DM7JX8U MI TT9N02I DM7JX8U MN Orexin receptor type 2 (HCRTR2) DM7JX8U MT DTT DM7JX8U MA Antagonist DM7JX8U RN Substituted cyclopentanes, tetrahydrofurans and pyrrolidines as orexin-1-receptor antagonists for treatment of various CNS disorders (WO2015/055994; WO2015/124932; WO2015/124934).Expert Opin Ther Pat. 2016;26(3):409-15. DM7JX8U RU https://www.ncbi.nlm.nih.gov/pubmed/26593218 DM7I8ZV DI DM7I8ZV DM7I8ZV DN 1,2-diamino cyclopentane-based derivative 9 DM7I8ZV MI TT60Q8D DM7I8ZV MN Orexin receptor type 1 (HCRTR1) DM7I8ZV MT DTT DM7I8ZV MA Antagonist DM7I8ZV RN Substituted cyclopentanes, tetrahydrofurans and pyrrolidines as orexin-1-receptor antagonists for treatment of various CNS disorders (WO2015/055994; WO2015/124932; WO2015/124934).Expert Opin Ther Pat. 2016;26(3):409-15. DM7I8ZV RU https://www.ncbi.nlm.nih.gov/pubmed/26593218 DM7I8ZV DI DM7I8ZV DM7I8ZV DN 1,2-diamino cyclopentane-based derivative 9 DM7I8ZV MI TT9N02I DM7I8ZV MN Orexin receptor type 2 (HCRTR2) DM7I8ZV MT DTT DM7I8ZV MA Antagonist DM7I8ZV RN Substituted cyclopentanes, tetrahydrofurans and pyrrolidines as orexin-1-receptor antagonists for treatment of various CNS disorders (WO2015/055994; WO2015/124932; WO2015/124934).Expert Opin Ther Pat. 2016;26(3):409-15. DM7I8ZV RU https://www.ncbi.nlm.nih.gov/pubmed/26593218 DMRFXMB DI DMRFXMB DMRFXMB DN 1,2-dihydroindazolo[4,3-bc][1,5]benzoxazepine derivative 1 DMRFXMB MI TTCZOF2 DMRFXMB MN Pyruvate dehydrogenase kinase 1 (PDHK1) DMRFXMB MT DTT DMRFXMB MA Inhibitor DMRFXMB RN PDK1 disruptors and modulators: a patent review.Expert Opin Ther Pat. 2015 May;25(5):513-37. DMRFXMB RU https://www.ncbi.nlm.nih.gov/pubmed/25684022 DMJMCNP DI DMJMCNP DMJMCNP DN 1,3,4-oxadiazole derivative 1 DMJMCNP MI TTNBFWK DMJMCNP MN Programmed cell death protein 1 (PD-1) DMJMCNP MT DTT DMJMCNP MA Inhibitor DMJMCNP RN A patent review on PD-1/PD-L1 antagonists: small molecules, peptides, and macrocycles (2015-2018).Expert Opin Ther Pat. 2018 Sep;28(9):665-678. DMJMCNP RU https://www.ncbi.nlm.nih.gov/pubmed/30107136 DMH26EO DI DMH26EO DMH26EO DN 1,3,4-oxadiazole derivative 2 DMH26EO MI TTNBFWK DMH26EO MN Programmed cell death protein 1 (PD-1) DMH26EO MT DTT DMH26EO MA Inhibitor DMH26EO RN A patent review on PD-1/PD-L1 antagonists: small molecules, peptides, and macrocycles (2015-2018).Expert Opin Ther Pat. 2018 Sep;28(9):665-678. DMH26EO RU https://www.ncbi.nlm.nih.gov/pubmed/30107136 DMSR0X6 DI DMSR0X6 DMSR0X6 DN 1,3,4-oxadiazole derivative 3 DMSR0X6 MI TT23XQV DMSR0X6 MN PD-1-PD-L1 interaction (PD-1/PD-L1 PPI) DMSR0X6 MT DTT DMSR0X6 MA Inhibitor DMSR0X6 RN A patent review on PD-1/PD-L1 antagonists: small molecules, peptides, and macrocycles (2015-2018).Expert Opin Ther Pat. 2018 Sep;28(9):665-678. DMSR0X6 RU https://www.ncbi.nlm.nih.gov/pubmed/30107136 DM4GR2C DI DM4GR2C DM4GR2C DN 1,3,4-oxadiazole derivative 4 DM4GR2C MI TT23XQV DM4GR2C MN PD-1-PD-L1 interaction (PD-1/PD-L1 PPI) DM4GR2C MT DTT DM4GR2C MA Inhibitor DM4GR2C RN A patent review on PD-1/PD-L1 antagonists: small molecules, peptides, and macrocycles (2015-2018).Expert Opin Ther Pat. 2018 Sep;28(9):665-678. DM4GR2C RU https://www.ncbi.nlm.nih.gov/pubmed/30107136 DMI5VZN DI DMI5VZN DMI5VZN DN 1,3,4-oxadiazole derivative 5 DMI5VZN MI TT23XQV DMI5VZN MN PD-1-PD-L1 interaction (PD-1/PD-L1 PPI) DMI5VZN MT DTT DMI5VZN MA Inhibitor DMI5VZN RN A patent review on PD-1/PD-L1 antagonists: small molecules, peptides, and macrocycles (2015-2018).Expert Opin Ther Pat. 2018 Sep;28(9):665-678. DMI5VZN RU https://www.ncbi.nlm.nih.gov/pubmed/30107136 DMIEZ6L DI DMIEZ6L DMIEZ6L DN 1,3,4-oxadiazole derivative 6 DMIEZ6L MI TT23XQV DMIEZ6L MN PD-1-PD-L1 interaction (PD-1/PD-L1 PPI) DMIEZ6L MT DTT DMIEZ6L MA Inhibitor DMIEZ6L RN A patent review on PD-1/PD-L1 antagonists: small molecules, peptides, and macrocycles (2015-2018).Expert Opin Ther Pat. 2018 Sep;28(9):665-678. DMIEZ6L RU https://www.ncbi.nlm.nih.gov/pubmed/30107136 DMAB8QF DI DMAB8QF DMAB8QF DN 1,3,4-thiadiazole derivative 1 DMAB8QF MI TT23XQV DMAB8QF MN PD-1-PD-L1 interaction (PD-1/PD-L1 PPI) DMAB8QF MT DTT DMAB8QF MA Inhibitor DMAB8QF RN A patent review on PD-1/PD-L1 antagonists: small molecules, peptides, and macrocycles (2015-2018).Expert Opin Ther Pat. 2018 Sep;28(9):665-678. DMAB8QF RU https://www.ncbi.nlm.nih.gov/pubmed/30107136 DMXIG07 DI DMXIG07 DMXIG07 DN 1,3,4-thiadiazole derivative 2 DMXIG07 MI TT23XQV DMXIG07 MN PD-1-PD-L1 interaction (PD-1/PD-L1 PPI) DMXIG07 MT DTT DMXIG07 MA Inhibitor DMXIG07 RN A patent review on PD-1/PD-L1 antagonists: small molecules, peptides, and macrocycles (2015-2018).Expert Opin Ther Pat. 2018 Sep;28(9):665-678. DMXIG07 RU https://www.ncbi.nlm.nih.gov/pubmed/30107136 DMLD7JU DI DMLD7JU DMLD7JU DN 1,3,5-triazine derivative 1 DMLD7JU MI TTMSFAW DMLD7JU MN Cannabinoid receptor 2 (CB2) DMLD7JU MT DTT DMLD7JU RN Cannabinoid receptor 2 (CB2) agonists and antagonists: a patent update.Expert Opin Ther Pat. 2016 Jul;26(7):843-56. DMLD7JU RU https://www.ncbi.nlm.nih.gov/pubmed/27215781 DMUS7O3 DI DMUS7O3 DMUS7O3 DN 1,3-dihydroxy phenyl derivative 1 DMUS7O3 MI TT23XQV DMUS7O3 MN PD-1-PD-L1 interaction (PD-1/PD-L1 PPI) DMUS7O3 MT DTT DMUS7O3 MA Inhibitor DMUS7O3 RN A patent review on PD-1/PD-L1 antagonists: small molecules, peptides, and macrocycles (2015-2018).Expert Opin Ther Pat. 2018 Sep;28(9):665-678. DMUS7O3 RU https://www.ncbi.nlm.nih.gov/pubmed/30107136 DM63NX5 DI DM63NX5 DM63NX5 DN 1,3-dihydroxy phenyl derivative 2 DM63NX5 MI TT23XQV DM63NX5 MN PD-1-PD-L1 interaction (PD-1/PD-L1 PPI) DM63NX5 MT DTT DM63NX5 MA Inhibitor DM63NX5 RN A patent review on PD-1/PD-L1 antagonists: small molecules, peptides, and macrocycles (2015-2018).Expert Opin Ther Pat. 2018 Sep;28(9):665-678. DM63NX5 RU https://www.ncbi.nlm.nih.gov/pubmed/30107136 DMZY3HC DI DMZY3HC DMZY3HC DN 1,5-diphenylpyrrolidin-2-one derivative 1 DMZY3HC MI TT6OEDT DMZY3HC MN Cannabinoid receptor 1 (CB1) DMZY3HC MT DTT DMZY3HC MA Antagonist DMZY3HC RN A comprehensive patents review on cannabinoid 1 receptor antagonists as antiobesity agents. Expert Opin Ther Pat. 2015 Oct;25(10):1093-116. DMZY3HC RU https://pubmed.ncbi.nlm.nih.gov/26161824 DMBR2Y9 DI DMBR2Y9 DMBR2Y9 DN 1,5-diphenylpyrrolidin-2-one derivative 2 DMBR2Y9 MI TT6OEDT DMBR2Y9 MN Cannabinoid receptor 1 (CB1) DMBR2Y9 MT DTT DMBR2Y9 MA Antagonist DMBR2Y9 RN A comprehensive patents review on cannabinoid 1 receptor antagonists as antiobesity agents. Expert Opin Ther Pat. 2015 Oct;25(10):1093-116. DMBR2Y9 RU https://pubmed.ncbi.nlm.nih.gov/26161824 DMEUO8G DI DMEUO8G DMEUO8G DN 1,5-di-substituted pyridine derivative 1 DMEUO8G MI TT7HF4W DMEUO8G MN Cyclin-dependent kinase 2 (CDK2) DMEUO8G MT DTT DMEUO8G MA Inhibitor DMEUO8G RN Cyclin-dependent kinase inhibitors for cancer therapy: a patent review (2009 - 2014).Expert Opin Ther Pat. 2015;25(9):953-70. DMEUO8G RU https://www.ncbi.nlm.nih.gov/pubmed/26161698 DMEUO8G DI DMEUO8G DMEUO8G DN 1,5-di-substituted pyridine derivative 1 DMEUO8G MI TT1LVF2 DMEUO8G MN Cyclin-dependent kinase 9 (CDK9) DMEUO8G MT DTT DMEUO8G MA Inhibitor DMEUO8G RN Cyclin-dependent kinase inhibitors for cancer therapy: a patent review (2009 - 2014).Expert Opin Ther Pat. 2015;25(9):953-70. DMEUO8G RU https://www.ncbi.nlm.nih.gov/pubmed/26161698 DMUQ9CF DI DMUQ9CF DMUQ9CF DN 1,6-diazanaphthalenes and pyrido[2,3-d] pyrimidine derivative 1 DMUQ9CF MI TTIXKA4 DMUQ9CF MN Ribosomal protein S6 kinase alpha-1 (RSK1) DMUQ9CF MT DTT DMUQ9CF MA Inhibitor DMUQ9CF RN Ribosomal S6 kinase (RSK) modulators: a patent review.Expert Opin Ther Pat. 2016 Sep;26(9):1061-78. DMUQ9CF RU https://www.ncbi.nlm.nih.gov/pubmed/27410995 DMPZ0U8 DI DMPZ0U8 DMPZ0U8 DN 1,6-diazanaphthalenes and pyrido[2,3-d] pyrimidine derivative 2 DMPZ0U8 MI TTIXKA4 DMPZ0U8 MN Ribosomal protein S6 kinase alpha-1 (RSK1) DMPZ0U8 MT DTT DMPZ0U8 MA Inhibitor DMPZ0U8 RN Ribosomal S6 kinase (RSK) modulators: a patent review.Expert Opin Ther Pat. 2016 Sep;26(9):1061-78. DMPZ0U8 RU https://www.ncbi.nlm.nih.gov/pubmed/27410995 DMF6W2Y DI DMF6W2Y DMF6W2Y DN 1,6-naphyridine-4-ketone fused heterocyclic derivative 1 DMF6W2Y MI TTOHSBA DMF6W2Y MN Vascular endothelial growth factor A (VEGFA) DMF6W2Y MT DTT DMF6W2Y MA Inhibitor DMF6W2Y RN VEGFR-2 inhibitors and the therapeutic applications thereof: a patent review (2012-2016).Expert Opin Ther Pat. 2017 Sep;27(9):987-1004. DMF6W2Y RU https://www.ncbi.nlm.nih.gov/pubmed/28621580 DMHNPSO DI DMHNPSO DMHNPSO DN 1190312-92-5 DMHNPSO MI TTIG67W DMHNPSO MN Lysine-specific demethylase 5A (KDM5A) DMHNPSO MT DTT DMHNPSO MA Inhibitor DMHNPSO RN Histone demethylase inhibitors. US10174026. DMHNPSO RU http://www.freepatentsonline.com/US10174026.html DMJRK9D DI DMJRK9D DMJRK9D DN 1313212-89-3 DMJRK9D MI TTNAFOU DMJRK9D MN Rotamase D (PPID) DMJRK9D MT DTT DMJRK9D MA Inhibitor DMJRK9D RN Inhibitors of cyclophilins and uses thereof. US8901295. DMJRK9D RU http://www.freepatentsonline.com/US8901295.html DMM2N4T DI DMM2N4T DMM2N4T DN 1607004-34-1 DMM2N4T MI TTYG6BU DMM2N4T MN Aggrecanase-1 (ADAMTS4) DMM2N4T MT DTT DMM2N4T MA Inhibitor DMM2N4T RN Aggrecanase inhibitors. US9206139. DMM2N4T RU http://www.freepatentsonline.com/US9206139.html DMWNKQ8 DI DMWNKQ8 DMWNKQ8 DN 1-aryl-4-methyl-[1,2,4]triazolo[4,3-a]quinoxaline derivative 1 DMWNKQ8 MI TTJGW1Z DMWNKQ8 MN Phosphodiesterase 2A (PDE2A) DMWNKQ8 MT DTT DMWNKQ8 MA Inhibitor DMWNKQ8 RN Towards selective phosphodiesterase 2A (PDE2A) inhibitors: a patent review (2010 - present).Expert Opin Ther Pat. 2016 Aug;26(8):933-46. DMWNKQ8 RU https://www.ncbi.nlm.nih.gov/pubmed/27321640 DMU6ST7 DI DMU6ST7 DMU6ST7 DN 1-aryl-4-methyl-[1,2,4]triazolo[4,3-a]quinoxaline derivative 2 DMU6ST7 MI TTJGW1Z DMU6ST7 MN Phosphodiesterase 2A (PDE2A) DMU6ST7 MT DTT DMU6ST7 MA Inhibitor DMU6ST7 RN Towards selective phosphodiesterase 2A (PDE2A) inhibitors: a patent review (2010 - present).Expert Opin Ther Pat. 2016 Aug;26(8):933-46. DMU6ST7 RU https://www.ncbi.nlm.nih.gov/pubmed/27321640 DM62K40 DI DM62K40 DM62K40 DN 1-aryl-4-methyl-[1,2,4]triazolo[4,3-a]quinoxaline derivative 3 DM62K40 MI TTJW4LU DM62K40 MN Phosphodiesterase 10A (PDE10) DM62K40 MT DTT DM62K40 MA Inhibitor DM62K40 RN Towards selective phosphodiesterase 2A (PDE2A) inhibitors: a patent review (2010 - present).Expert Opin Ther Pat. 2016 Aug;26(8):933-46. DM62K40 RU https://www.ncbi.nlm.nih.gov/pubmed/27321640 DM62K40 DI DM62K40 DM62K40 DN 1-aryl-4-methyl-[1,2,4]triazolo[4,3-a]quinoxaline derivative 3 DM62K40 MI TTJGW1Z DM62K40 MN Phosphodiesterase 2A (PDE2A) DM62K40 MT DTT DM62K40 MA Inhibitor DM62K40 RN Towards selective phosphodiesterase 2A (PDE2A) inhibitors: a patent review (2010 - present).Expert Opin Ther Pat. 2016 Aug;26(8):933-46. DM62K40 RU https://www.ncbi.nlm.nih.gov/pubmed/27321640 DMQSTG9 DI DMQSTG9 DMQSTG9 DN 1-aryl-4-methyl-[1,2,4]triazolo[4,3-a]quinoxaline derivative 4 DMQSTG9 MI TTJW4LU DMQSTG9 MN Phosphodiesterase 10A (PDE10) DMQSTG9 MT DTT DMQSTG9 MA Inhibitor DMQSTG9 RN Towards selective phosphodiesterase 2A (PDE2A) inhibitors: a patent review (2010 - present).Expert Opin Ther Pat. 2016 Aug;26(8):933-46. DMQSTG9 RU https://www.ncbi.nlm.nih.gov/pubmed/27321640 DMQSTG9 DI DMQSTG9 DMQSTG9 DN 1-aryl-4-methyl-[1,2,4]triazolo[4,3-a]quinoxaline derivative 4 DMQSTG9 MI TTJGW1Z DMQSTG9 MN Phosphodiesterase 2A (PDE2A) DMQSTG9 MT DTT DMQSTG9 MA Inhibitor DMQSTG9 RN Towards selective phosphodiesterase 2A (PDE2A) inhibitors: a patent review (2010 - present).Expert Opin Ther Pat. 2016 Aug;26(8):933-46. DMQSTG9 RU https://www.ncbi.nlm.nih.gov/pubmed/27321640 DM9E0ZD DI DM9E0ZD DM9E0ZD DN 1-aryl-4-methyl-[1,2,4]triazolo[4,3-a]quinoxaline derivative 5 DM9E0ZD MI TTJW4LU DM9E0ZD MN Phosphodiesterase 10A (PDE10) DM9E0ZD MT DTT DM9E0ZD MA Inhibitor DM9E0ZD RN Towards selective phosphodiesterase 2A (PDE2A) inhibitors: a patent review (2010 - present).Expert Opin Ther Pat. 2016 Aug;26(8):933-46. DM9E0ZD RU https://www.ncbi.nlm.nih.gov/pubmed/27321640 DM9E0ZD DI DM9E0ZD DM9E0ZD DN 1-aryl-4-methyl-[1,2,4]triazolo[4,3-a]quinoxaline derivative 5 DM9E0ZD MI TTJGW1Z DM9E0ZD MN Phosphodiesterase 2A (PDE2A) DM9E0ZD MT DTT DM9E0ZD MA Inhibitor DM9E0ZD RN Towards selective phosphodiesterase 2A (PDE2A) inhibitors: a patent review (2010 - present).Expert Opin Ther Pat. 2016 Aug;26(8):933-46. DM9E0ZD RU https://www.ncbi.nlm.nih.gov/pubmed/27321640 DM826JW DI DM826JW DM826JW DN 1-aryl-4-methyl-[1,2,4]triazolo[4,3-a]quinoxaline derivative 6 DM826JW MI TTJW4LU DM826JW MN Phosphodiesterase 10A (PDE10) DM826JW MT DTT DM826JW MA Inhibitor DM826JW RN Towards selective phosphodiesterase 2A (PDE2A) inhibitors: a patent review (2010 - present).Expert Opin Ther Pat. 2016 Aug;26(8):933-46. DM826JW RU https://www.ncbi.nlm.nih.gov/pubmed/27321640 DM826JW DI DM826JW DM826JW DN 1-aryl-4-methyl-[1,2,4]triazolo[4,3-a]quinoxaline derivative 6 DM826JW MI TTJGW1Z DM826JW MN Phosphodiesterase 2A (PDE2A) DM826JW MT DTT DM826JW MA Inhibitor DM826JW RN Towards selective phosphodiesterase 2A (PDE2A) inhibitors: a patent review (2010 - present).Expert Opin Ther Pat. 2016 Aug;26(8):933-46. DM826JW RU https://www.ncbi.nlm.nih.gov/pubmed/27321640 DML8RVS DI DML8RVS DML8RVS DN 1-Benzyl-3-bromo-1H-pyrrole-2,5-dione DML8RVS MI TTWME23 DML8RVS MN Regulator of G-protein signaling 8 (RGS8) DML8RVS MT DTT DML8RVS MA Inhibitor DML8RVS RN Small molecule inhibitors of RGS proteins. US8865750. DML8RVS RU http://www.freepatentsonline.com/US8865750.html DMWY9GM DI DMWY9GM DMWY9GM DN 1-Benzyl-3-p-tolyl-1H-pyrrole-2,5-dione DMWY9GM MI TTWME23 DMWY9GM MN Regulator of G-protein signaling 8 (RGS8) DMWY9GM MT DTT DMWY9GM MA Inhibitor DMWY9GM RN Small molecule inhibitors of RGS proteins. US8865750. DMWY9GM RU http://www.freepatentsonline.com/US8865750.html DMK75BT DI DMK75BT DMK75BT DN 1-hydroxyl-3,5-bis(4-hydroxylstyryl)benzene derivative 1 DMK75BT MI TTSXVID DMK75BT MN Nuclear factor NF-kappa-B (NFKB) DMK75BT MT DTT DMK75BT MA Inhibitor DMK75BT RN Novel NF-B inhibitors: a patent review (2011 - 2014).Expert Opin Ther Pat. 2015 Mar;25(3):319-34. DMK75BT RU https://www.ncbi.nlm.nih.gov/pubmed/25553724 DMIWQZ5 DI DMIWQZ5 DMIWQZ5 DN 1-hydroxyl-3,5-bis(4-hydroxylstyryl)benzene derivative 2 DMIWQZ5 MI TTSXVID DMIWQZ5 MN Nuclear factor NF-kappa-B (NFKB) DMIWQZ5 MT DTT DMIWQZ5 MA Inhibitor DMIWQZ5 RN Novel NF-B inhibitors: a patent review (2011 - 2014).Expert Opin Ther Pat. 2015 Mar;25(3):319-34. DMIWQZ5 RU https://www.ncbi.nlm.nih.gov/pubmed/25553724 DMNXAUZ DI DMNXAUZ DMNXAUZ DN 1-hydroxyl-3,5-bis(4-hydroxylstyryl)benzene derivative 3 DMNXAUZ MI TTSXVID DMNXAUZ MN Nuclear factor NF-kappa-B (NFKB) DMNXAUZ MT DTT DMNXAUZ MA Inhibitor DMNXAUZ RN Novel NF-B inhibitors: a patent review (2011 - 2014).Expert Opin Ther Pat. 2015 Mar;25(3):319-34. DMNXAUZ RU https://www.ncbi.nlm.nih.gov/pubmed/25553724 DMV2W9Z DI DMV2W9Z DMV2W9Z DN 1-hydroxyl-3,5-bis(4-hydroxylstyryl)benzene derivative 4 DMV2W9Z MI TTSXVID DMV2W9Z MN Nuclear factor NF-kappa-B (NFKB) DMV2W9Z MT DTT DMV2W9Z MA Inhibitor DMV2W9Z RN Novel NF-B inhibitors: a patent review (2011 - 2014).Expert Opin Ther Pat. 2015 Mar;25(3):319-34. DMV2W9Z RU https://www.ncbi.nlm.nih.gov/pubmed/25553724 DMS5EHL DI DMS5EHL DMS5EHL DN 1-phenyl-1,3,4-triazole derivative 1 DMS5EHL MI TT956B0 DMS5EHL MN Keap1-Nrf2[DLG] PPI (KEAP1-Nrf2 DLG) DMS5EHL MT DTT DMS5EHL MA Modulator DMS5EHL RN Recent progress in the development of small molecule Nrf2 modulators: a patent review (2012-2016).Expert Opin Ther Pat. 2017 Jul;27(7):763-785. DMS5EHL RU https://www.ncbi.nlm.nih.gov/pubmed/28454500 DMS5EHL DI DMS5EHL DMS5EHL DN 1-phenyl-1,3,4-triazole derivative 1 DMS5EHL MI TTA6ZN2 DMS5EHL MN Nuclear factor erythroid 2-related factor 2 (Nrf2) DMS5EHL MT DTT DMS5EHL MA Inhibitor DMS5EHL RN Recent progress in the development of small molecule Nrf2 modulators: a patent review (2012-2016).Expert Opin Ther Pat. 2017 Jul;27(7):763-785. DMS5EHL RU https://www.ncbi.nlm.nih.gov/pubmed/28454500 DMO7310 DI DMO7310 DMO7310 DN 1-phenyl-1,3,4-triazole derivative 2 DMO7310 MI TT956B0 DMO7310 MN Keap1-Nrf2[DLG] PPI (KEAP1-Nrf2 DLG) DMO7310 MT DTT DMO7310 MA Modulator DMO7310 RN Recent progress in the development of small molecule Nrf2 modulators: a patent review (2012-2016).Expert Opin Ther Pat. 2017 Jul;27(7):763-785. DMO7310 RU https://www.ncbi.nlm.nih.gov/pubmed/28454500 DMO7310 DI DMO7310 DMO7310 DN 1-phenyl-1,3,4-triazole derivative 2 DMO7310 MI TTA6ZN2 DMO7310 MN Nuclear factor erythroid 2-related factor 2 (Nrf2) DMO7310 MT DTT DMO7310 MA Inhibitor DMO7310 RN Recent progress in the development of small molecule Nrf2 modulators: a patent review (2012-2016).Expert Opin Ther Pat. 2017 Jul;27(7):763-785. DMO7310 RU https://www.ncbi.nlm.nih.gov/pubmed/28454500 DMU8FC1 DI DMU8FC1 DMU8FC1 DN 1-phenyl-1,3,4-triazole derivative 3 DMU8FC1 MI TT956B0 DMU8FC1 MN Keap1-Nrf2[DLG] PPI (KEAP1-Nrf2 DLG) DMU8FC1 MT DTT DMU8FC1 MA Modulator DMU8FC1 RN Recent progress in the development of small molecule Nrf2 modulators: a patent review (2012-2016).Expert Opin Ther Pat. 2017 Jul;27(7):763-785. DMU8FC1 RU https://www.ncbi.nlm.nih.gov/pubmed/28454500 DMU8FC1 DI DMU8FC1 DMU8FC1 DN 1-phenyl-1,3,4-triazole derivative 3 DMU8FC1 MI TTA6ZN2 DMU8FC1 MN Nuclear factor erythroid 2-related factor 2 (Nrf2) DMU8FC1 MT DTT DMU8FC1 MA Inhibitor DMU8FC1 RN Recent progress in the development of small molecule Nrf2 modulators: a patent review (2012-2016).Expert Opin Ther Pat. 2017 Jul;27(7):763-785. DMU8FC1 RU https://www.ncbi.nlm.nih.gov/pubmed/28454500 DMOY5EK DI DMOY5EK DMOY5EK DN 2-(substituted ethynyl)quinoline derivative 1 DMOY5EK MI TTHS256 DMOY5EK MN Metabotropic glutamate receptor 5 (mGluR5) DMOY5EK MT DTT DMOY5EK MA Antagonist DMOY5EK RN mGlu5 negative allosteric modulators: a patent review (2013 - 2016).Expert Opin Ther Pat. 2017 Jun;27(6):691-706. DMOY5EK RU https://www.ncbi.nlm.nih.gov/pubmed/28067079 DMPCYSW DI DMPCYSW DMPCYSW DN 2-(substituted ethynyl)quinoline derivative 2 DMPCYSW MI TTHS256 DMPCYSW MN Metabotropic glutamate receptor 5 (mGluR5) DMPCYSW MT DTT DMPCYSW MA Antagonist DMPCYSW RN mGlu5 negative allosteric modulators: a patent review (2013 - 2016).Expert Opin Ther Pat. 2017 Jun;27(6):691-706. DMPCYSW RU https://www.ncbi.nlm.nih.gov/pubmed/28067079 DMMF8A1 DI DMMF8A1 DMMF8A1 DN 2-(substituted ethynyl)quinoline derivative 3 DMMF8A1 MI TTHS256 DMMF8A1 MN Metabotropic glutamate receptor 5 (mGluR5) DMMF8A1 MT DTT DMMF8A1 MA Antagonist DMMF8A1 RN mGlu5 negative allosteric modulators: a patent review (2013 - 2016).Expert Opin Ther Pat. 2017 Jun;27(6):691-706. DMMF8A1 RU https://www.ncbi.nlm.nih.gov/pubmed/28067079 DMTXZUF DI DMTXZUF DMTXZUF DN 2-(substituted ethynyl)quinoline derivative 4 DMTXZUF MI TTHS256 DMTXZUF MN Metabotropic glutamate receptor 5 (mGluR5) DMTXZUF MT DTT DMTXZUF MA Antagonist DMTXZUF RN mGlu5 negative allosteric modulators: a patent review (2013 - 2016).Expert Opin Ther Pat. 2017 Jun;27(6):691-706. DMTXZUF RU https://www.ncbi.nlm.nih.gov/pubmed/28067079 DMRTDOA DI DMRTDOA DMRTDOA DN 2,2-bipyridyl derivative 1 DMRTDOA MI TT0RGE9 DMRTDOA MN Lysine-specific demethylase 4 (KDM4) DMRTDOA MT DTT DMRTDOA MA Inhibitor DMRTDOA RN KDM4 histone demethylase inhibitors for anti-cancer agents: a patent review.Expert Opin Ther Pat. 2015 Feb;25(2):135-44. DMRTDOA RU https://www.ncbi.nlm.nih.gov/pubmed/25468267 DMYLQZ1 DI DMYLQZ1 DMYLQZ1 DN 2,2-bipyridyl derivative 2 DMYLQZ1 MI TT0RGE9 DMYLQZ1 MN Lysine-specific demethylase 4 (KDM4) DMYLQZ1 MT DTT DMYLQZ1 MA Inhibitor DMYLQZ1 RN KDM4 histone demethylase inhibitors for anti-cancer agents: a patent review.Expert Opin Ther Pat. 2015 Feb;25(2):135-44. DMYLQZ1 RU https://www.ncbi.nlm.nih.gov/pubmed/25468267 DMPQF78 DI DMPQF78 DMPQF78 DN 2,2-bipyridyl derivative 3 DMPQF78 MI TT0RGE9 DMPQF78 MN Lysine-specific demethylase 4 (KDM4) DMPQF78 MT DTT DMPQF78 MA Inhibitor DMPQF78 RN KDM4 histone demethylase inhibitors for anti-cancer agents: a patent review.Expert Opin Ther Pat. 2015 Feb;25(2):135-44. DMPQF78 RU https://www.ncbi.nlm.nih.gov/pubmed/25468267 DMTYPBM DI DMTYPBM DMTYPBM DN 2,2-bipyridyl derivative 4 DMTYPBM MI TT0RGE9 DMTYPBM MN Lysine-specific demethylase 4 (KDM4) DMTYPBM MT DTT DMTYPBM MA Inhibitor DMTYPBM RN KDM4 histone demethylase inhibitors for anti-cancer agents: a patent review.Expert Opin Ther Pat. 2015 Feb;25(2):135-44. DMTYPBM RU https://www.ncbi.nlm.nih.gov/pubmed/25468267 DMEJOPL DI DMEJOPL DMEJOPL DN 2,2-bipyridyl derivative 5 DMEJOPL MI TT0RGE9 DMEJOPL MN Lysine-specific demethylase 4 (KDM4) DMEJOPL MT DTT DMEJOPL MA Inhibitor DMEJOPL RN KDM4 histone demethylase inhibitors for anti-cancer agents: a patent review.Expert Opin Ther Pat. 2015 Feb;25(2):135-44. DMEJOPL RU https://www.ncbi.nlm.nih.gov/pubmed/25468267 DMWRBSP DI DMWRBSP DMWRBSP DN 2,2-dimethylbenzopyran derivative 1 DMWRBSP MI TTUX68I DMWRBSP MN Hypoxia-inducible factor 1 (HIF-1) DMWRBSP MT DTT DMWRBSP MA Inhibitor DMWRBSP RN Hypoxia-inducible factor (HIF) inhibitors: a patent survey (2011-2015).Expert Opin Ther Pat. 2016;26(3):309-22. DMWRBSP RU https://www.ncbi.nlm.nih.gov/pubmed/26882240 DM9XUYM DI DM9XUYM DM9XUYM DN 2,2-dimethylbenzopyran derivative 2 DM9XUYM MI TTUX68I DM9XUYM MN Hypoxia-inducible factor 1 (HIF-1) DM9XUYM MT DTT DM9XUYM MA Inhibitor DM9XUYM RN Hypoxia-inducible factor (HIF) inhibitors: a patent survey (2011-2015).Expert Opin Ther Pat. 2016;26(3):309-22. DM9XUYM RU https://www.ncbi.nlm.nih.gov/pubmed/26882240 DMTCPSQ DI DMTCPSQ DMTCPSQ DN 2,2-dimethylbenzopyran derivative 3 DMTCPSQ MI TTUX68I DMTCPSQ MN Hypoxia-inducible factor 1 (HIF-1) DMTCPSQ MT DTT DMTCPSQ MA Inhibitor DMTCPSQ RN Hypoxia-inducible factor (HIF) inhibitors: a patent survey (2011-2015).Expert Opin Ther Pat. 2016;26(3):309-22. DMTCPSQ RU https://www.ncbi.nlm.nih.gov/pubmed/26882240 DMD2KRW DI DMD2KRW DMD2KRW DN 2,3-diamino-benzo[b]thiophene derivative 1 DMD2KRW MI TTZJYKH DMD2KRW MN Indoleamine 2,3-dioxygenase 1 (IDO1) DMD2KRW MT DTT DMD2KRW MA Inhibitor DMD2KRW RN Inhibitors of the kynurenine pathway as neurotherapeutics: a patent review (2012-2015).Expert Opin Ther Pat. 2016 Jul;26(7):815-32. DMD2KRW RU https://www.ncbi.nlm.nih.gov/pubmed/27172114 DMD2KRW DI DMD2KRW DMD2KRW DN 2,3-diamino-benzo[b]thiophene derivative 1 DMD2KRW MI TTALN9W DMD2KRW MN Indoleamine 2,3-dioxygenase 2 (IDO2) DMD2KRW MT DTT DMD2KRW MA Inhibitor DMD2KRW RN Inhibitors of the kynurenine pathway as neurotherapeutics: a patent review (2012-2015).Expert Opin Ther Pat. 2016 Jul;26(7):815-32. DMD2KRW RU https://www.ncbi.nlm.nih.gov/pubmed/27172114 DMD2KRW DI DMD2KRW DMD2KRW DN 2,3-diamino-benzo[b]thiophene derivative 1 DMD2KRW MI TTXNCBV DMD2KRW MN Tryptophan 2,3-dioxygenase (TDO) DMD2KRW MT DTT DMD2KRW MA Inhibitor DMD2KRW RN Inhibitors of the kynurenine pathway as neurotherapeutics: a patent review (2012-2015).Expert Opin Ther Pat. 2016 Jul;26(7):815-32. DMD2KRW RU https://www.ncbi.nlm.nih.gov/pubmed/27172114 DMDYXKT DI DMDYXKT DMDYXKT DN 2,3-diamino-benzo[b]thiophene derivative 2 DMDYXKT MI TTZJYKH DMDYXKT MN Indoleamine 2,3-dioxygenase 1 (IDO1) DMDYXKT MT DTT DMDYXKT MA Inhibitor DMDYXKT RN Inhibitors of the kynurenine pathway as neurotherapeutics: a patent review (2012-2015).Expert Opin Ther Pat. 2016 Jul;26(7):815-32. DMDYXKT RU https://www.ncbi.nlm.nih.gov/pubmed/27172114 DMDYXKT DI DMDYXKT DMDYXKT DN 2,3-diamino-benzo[b]thiophene derivative 2 DMDYXKT MI TTALN9W DMDYXKT MN Indoleamine 2,3-dioxygenase 2 (IDO2) DMDYXKT MT DTT DMDYXKT MA Inhibitor DMDYXKT RN Inhibitors of the kynurenine pathway as neurotherapeutics: a patent review (2012-2015).Expert Opin Ther Pat. 2016 Jul;26(7):815-32. DMDYXKT RU https://www.ncbi.nlm.nih.gov/pubmed/27172114 DMDYXKT DI DMDYXKT DMDYXKT DN 2,3-diamino-benzo[b]thiophene derivative 2 DMDYXKT MI TTXNCBV DMDYXKT MN Tryptophan 2,3-dioxygenase (TDO) DMDYXKT MT DTT DMDYXKT MA Inhibitor DMDYXKT RN Inhibitors of the kynurenine pathway as neurotherapeutics: a patent review (2012-2015).Expert Opin Ther Pat. 2016 Jul;26(7):815-32. DMDYXKT RU https://www.ncbi.nlm.nih.gov/pubmed/27172114 DMR7QKL DI DMR7QKL DMR7QKL DN 2,3-diamino-benzo[b]thiophene derivative 3 DMR7QKL MI TTZJYKH DMR7QKL MN Indoleamine 2,3-dioxygenase 1 (IDO1) DMR7QKL MT DTT DMR7QKL MA Inhibitor DMR7QKL RN Inhibitors of the kynurenine pathway as neurotherapeutics: a patent review (2012-2015).Expert Opin Ther Pat. 2016 Jul;26(7):815-32. DMR7QKL RU https://www.ncbi.nlm.nih.gov/pubmed/27172114 DMR7QKL DI DMR7QKL DMR7QKL DN 2,3-diamino-benzo[b]thiophene derivative 3 DMR7QKL MI TTXNCBV DMR7QKL MN Tryptophan 2,3-dioxygenase (TDO) DMR7QKL MT DTT DMR7QKL MA Inhibitor DMR7QKL RN Inhibitors of the kynurenine pathway as neurotherapeutics: a patent review (2012-2015).Expert Opin Ther Pat. 2016 Jul;26(7):815-32. DMR7QKL RU https://www.ncbi.nlm.nih.gov/pubmed/27172114 DMEDFNC DI DMEDFNC DMEDFNC DN 2,3-diamino-benzo[b]thiophene derivative 4 DMEDFNC MI TTZJYKH DMEDFNC MN Indoleamine 2,3-dioxygenase 1 (IDO1) DMEDFNC MT DTT DMEDFNC MA Inhibitor DMEDFNC RN Inhibitors of the kynurenine pathway as neurotherapeutics: a patent review (2012-2015).Expert Opin Ther Pat. 2016 Jul;26(7):815-32. DMEDFNC RU https://www.ncbi.nlm.nih.gov/pubmed/27172114 DMEDFNC DI DMEDFNC DMEDFNC DN 2,3-diamino-benzo[b]thiophene derivative 4 DMEDFNC MI TTALN9W DMEDFNC MN Indoleamine 2,3-dioxygenase 2 (IDO2) DMEDFNC MT DTT DMEDFNC MA Inhibitor DMEDFNC RN Inhibitors of the kynurenine pathway as neurotherapeutics: a patent review (2012-2015).Expert Opin Ther Pat. 2016 Jul;26(7):815-32. DMEDFNC RU https://www.ncbi.nlm.nih.gov/pubmed/27172114 DMEDFNC DI DMEDFNC DMEDFNC DN 2,3-diamino-benzo[b]thiophene derivative 4 DMEDFNC MI TTXNCBV DMEDFNC MN Tryptophan 2,3-dioxygenase (TDO) DMEDFNC MT DTT DMEDFNC MA Inhibitor DMEDFNC RN Inhibitors of the kynurenine pathway as neurotherapeutics: a patent review (2012-2015).Expert Opin Ther Pat. 2016 Jul;26(7):815-32. DMEDFNC RU https://www.ncbi.nlm.nih.gov/pubmed/27172114 DM05WXD DI DM05WXD DM05WXD DN 2,3-diamino-benzo[b]thiophene derivative 5 DM05WXD MI TTZJYKH DM05WXD MN Indoleamine 2,3-dioxygenase 1 (IDO1) DM05WXD MT DTT DM05WXD MA Inhibitor DM05WXD RN Inhibitors of the kynurenine pathway as neurotherapeutics: a patent review (2012-2015).Expert Opin Ther Pat. 2016 Jul;26(7):815-32. DM05WXD RU https://www.ncbi.nlm.nih.gov/pubmed/27172114 DM05WXD DI DM05WXD DM05WXD DN 2,3-diamino-benzo[b]thiophene derivative 5 DM05WXD MI TTALN9W DM05WXD MN Indoleamine 2,3-dioxygenase 2 (IDO2) DM05WXD MT DTT DM05WXD MA Inhibitor DM05WXD RN Inhibitors of the kynurenine pathway as neurotherapeutics: a patent review (2012-2015).Expert Opin Ther Pat. 2016 Jul;26(7):815-32. DM05WXD RU https://www.ncbi.nlm.nih.gov/pubmed/27172114 DM05WXD DI DM05WXD DM05WXD DN 2,3-diamino-benzo[b]thiophene derivative 5 DM05WXD MI TTXNCBV DM05WXD MN Tryptophan 2,3-dioxygenase (TDO) DM05WXD MT DTT DM05WXD MA Inhibitor DM05WXD RN Inhibitors of the kynurenine pathway as neurotherapeutics: a patent review (2012-2015).Expert Opin Ther Pat. 2016 Jul;26(7):815-32. DM05WXD RU https://www.ncbi.nlm.nih.gov/pubmed/27172114 DMINE6V DI DMINE6V DMINE6V DN 2,3-diamino-benzo[b]thiophene derivative 6 DMINE6V MI TTZJYKH DMINE6V MN Indoleamine 2,3-dioxygenase 1 (IDO1) DMINE6V MT DTT DMINE6V MA Inhibitor DMINE6V RN Inhibitors of the kynurenine pathway as neurotherapeutics: a patent review (2012-2015).Expert Opin Ther Pat. 2016 Jul;26(7):815-32. DMINE6V RU https://www.ncbi.nlm.nih.gov/pubmed/27172114 DMINE6V DI DMINE6V DMINE6V DN 2,3-diamino-benzo[b]thiophene derivative 6 DMINE6V MI TTALN9W DMINE6V MN Indoleamine 2,3-dioxygenase 2 (IDO2) DMINE6V MT DTT DMINE6V MA Inhibitor DMINE6V RN Inhibitors of the kynurenine pathway as neurotherapeutics: a patent review (2012-2015).Expert Opin Ther Pat. 2016 Jul;26(7):815-32. DMINE6V RU https://www.ncbi.nlm.nih.gov/pubmed/27172114 DMINE6V DI DMINE6V DMINE6V DN 2,3-diamino-benzo[b]thiophene derivative 6 DMINE6V MI TTXNCBV DMINE6V MN Tryptophan 2,3-dioxygenase (TDO) DMINE6V MT DTT DMINE6V MA Inhibitor DMINE6V RN Inhibitors of the kynurenine pathway as neurotherapeutics: a patent review (2012-2015).Expert Opin Ther Pat. 2016 Jul;26(7):815-32. DMINE6V RU https://www.ncbi.nlm.nih.gov/pubmed/27172114 DMQVMNJ DI DMQVMNJ DMQVMNJ DN 2,3-diamino-benzo[b]thiophene derivative 7 DMQVMNJ MI TTZJYKH DMQVMNJ MN Indoleamine 2,3-dioxygenase 1 (IDO1) DMQVMNJ MT DTT DMQVMNJ MA Inhibitor DMQVMNJ RN Inhibitors of the kynurenine pathway as neurotherapeutics: a patent review (2012-2015).Expert Opin Ther Pat. 2016 Jul;26(7):815-32. DMQVMNJ RU https://www.ncbi.nlm.nih.gov/pubmed/27172114 DMQVMNJ DI DMQVMNJ DMQVMNJ DN 2,3-diamino-benzo[b]thiophene derivative 7 DMQVMNJ MI TTALN9W DMQVMNJ MN Indoleamine 2,3-dioxygenase 2 (IDO2) DMQVMNJ MT DTT DMQVMNJ MA Inhibitor DMQVMNJ RN Inhibitors of the kynurenine pathway as neurotherapeutics: a patent review (2012-2015).Expert Opin Ther Pat. 2016 Jul;26(7):815-32. DMQVMNJ RU https://www.ncbi.nlm.nih.gov/pubmed/27172114 DMQVMNJ DI DMQVMNJ DMQVMNJ DN 2,3-diamino-benzo[b]thiophene derivative 7 DMQVMNJ MI TTXNCBV DMQVMNJ MN Tryptophan 2,3-dioxygenase (TDO) DMQVMNJ MT DTT DMQVMNJ MA Inhibitor DMQVMNJ RN Inhibitors of the kynurenine pathway as neurotherapeutics: a patent review (2012-2015).Expert Opin Ther Pat. 2016 Jul;26(7):815-32. DMQVMNJ RU https://www.ncbi.nlm.nih.gov/pubmed/27172114 DM5O8K0 DI DM5O8K0 DM5O8K0 DN 2,3-diamino-benzo[b]thiophene derivative 8 DM5O8K0 MI TTZJYKH DM5O8K0 MN Indoleamine 2,3-dioxygenase 1 (IDO1) DM5O8K0 MT DTT DM5O8K0 MA Inhibitor DM5O8K0 RN Inhibitors of the kynurenine pathway as neurotherapeutics: a patent review (2012-2015).Expert Opin Ther Pat. 2016 Jul;26(7):815-32. DM5O8K0 RU https://www.ncbi.nlm.nih.gov/pubmed/27172114 DM5O8K0 DI DM5O8K0 DM5O8K0 DN 2,3-diamino-benzo[b]thiophene derivative 8 DM5O8K0 MI TTALN9W DM5O8K0 MN Indoleamine 2,3-dioxygenase 2 (IDO2) DM5O8K0 MT DTT DM5O8K0 MA Inhibitor DM5O8K0 RN Inhibitors of the kynurenine pathway as neurotherapeutics: a patent review (2012-2015).Expert Opin Ther Pat. 2016 Jul;26(7):815-32. DM5O8K0 RU https://www.ncbi.nlm.nih.gov/pubmed/27172114 DM5O8K0 DI DM5O8K0 DM5O8K0 DN 2,3-diamino-benzo[b]thiophene derivative 8 DM5O8K0 MI TTXNCBV DM5O8K0 MN Tryptophan 2,3-dioxygenase (TDO) DM5O8K0 MT DTT DM5O8K0 MA Inhibitor DM5O8K0 RN Inhibitors of the kynurenine pathway as neurotherapeutics: a patent review (2012-2015).Expert Opin Ther Pat. 2016 Jul;26(7):815-32. DM5O8K0 RU https://www.ncbi.nlm.nih.gov/pubmed/27172114 DMMFZKC DI DMMFZKC DMMFZKC DN 2-alkyloxy-3-phenylethynyl-4a,5-dihydropyrido[2,3-b]pyrazine derivative 1 DMMFZKC MI TT2F4OL DMMFZKC MN Tissue transglutaminase (TG2) DMMFZKC MT DTT DMMFZKC MA Inhibitor DMMFZKC RN Transglutaminase inhibitors: a patent review.Expert Opin Ther Pat. 2016;26(1):49-63. DMMFZKC RU https://www.ncbi.nlm.nih.gov/pubmed/26560530 DMLXQET DI DMLXQET DMLXQET DN 2-cycloalkyl resorcinol cannabinoid ligand derivative 1 DMLXQET MI TT6OEDT DMLXQET MN Cannabinoid receptor 1 (CB1) DMLXQET MT DTT DMLXQET RN Cannabinoid receptor 2 (CB2) agonists and antagonists: a patent update.Expert Opin Ther Pat. 2016 Jul;26(7):843-56. DMLXQET RU https://www.ncbi.nlm.nih.gov/pubmed/27215781 DMLXQET DI DMLXQET DMLXQET DN 2-cycloalkyl resorcinol cannabinoid ligand derivative 1 DMLXQET MI TTMSFAW DMLXQET MN Cannabinoid receptor 2 (CB2) DMLXQET MT DTT DMLXQET RN Cannabinoid receptor 2 (CB2) agonists and antagonists: a patent update.Expert Opin Ther Pat. 2016 Jul;26(7):843-56. DMLXQET RU https://www.ncbi.nlm.nih.gov/pubmed/27215781 DMB65TO DI DMB65TO DMB65TO DN 2-cycloalkyl resorcinol cannabinoid ligand derivative 2 DMB65TO MI TT6OEDT DMB65TO MN Cannabinoid receptor 1 (CB1) DMB65TO MT DTT DMB65TO RN Cannabinoid receptor 2 (CB2) agonists and antagonists: a patent update.Expert Opin Ther Pat. 2016 Jul;26(7):843-56. DMB65TO RU https://www.ncbi.nlm.nih.gov/pubmed/27215781 DMB65TO DI DMB65TO DMB65TO DN 2-cycloalkyl resorcinol cannabinoid ligand derivative 2 DMB65TO MI TTMSFAW DMB65TO MN Cannabinoid receptor 2 (CB2) DMB65TO MT DTT DMB65TO RN Cannabinoid receptor 2 (CB2) agonists and antagonists: a patent update.Expert Opin Ther Pat. 2016 Jul;26(7):843-56. DMB65TO RU https://www.ncbi.nlm.nih.gov/pubmed/27215781 DMTJ1G8 DI DMTJ1G8 DMTJ1G8 DN 2-cyclopropyl-4-substituted-phenoxy-quinoline derivative 1 DMTJ1G8 MI TTPADOQ DMTJ1G8 MN HMG-CoA reductase (HMGCR) DMTJ1G8 MT DTT DMTJ1G8 MA Inhibitor DMTJ1G8 RN HMG-CoA Reductase inhibitors: an updated review of patents of novel compounds and formulations (2011-2015).Expert Opin Ther Pat. 2016 Nov;26(11):1257-1272. DMTJ1G8 RU https://www.ncbi.nlm.nih.gov/pubmed/27537201 DMHYIAV DI DMHYIAV DMHYIAV DN 2-ethyl-3-(4-hydroxy) benzoyl benzofuran derivative 1 DMHYIAV MI TTA592U DMHYIAV MN Urate anion exchanger 1 (URAT1) DMHYIAV MT DTT DMHYIAV MA Inhibitor DMHYIAV RN Urate transporter URAT1 inhibitors: a patent review (2012 - 2015).Expert Opin Ther Pat. 2016 Jul 30:1-10. DMHYIAV RU https://www.ncbi.nlm.nih.gov/pubmed/27414413 DMER2ZQ DI DMER2ZQ DMER2ZQ DN 2-hydroxybenzamide derivative 1 DMER2ZQ MI TT3Z6Y9 DMER2ZQ MN Cysteines of Keap1 (KEAP1 Cysteines) DMER2ZQ MT DTT DMER2ZQ MA Modulator DMER2ZQ RN Recent progress in the development of small molecule Nrf2 modulators: a patent review (2012-2016).Expert Opin Ther Pat. 2017 Jul;27(7):763-785. DMER2ZQ RU https://www.ncbi.nlm.nih.gov/pubmed/28454500 DMER2ZQ DI DMER2ZQ DMER2ZQ DN 2-hydroxybenzamide derivative 1 DMER2ZQ MI TTA6ZN2 DMER2ZQ MN Nuclear factor erythroid 2-related factor 2 (Nrf2) DMER2ZQ MT DTT DMER2ZQ MA Activator DMER2ZQ RN Recent progress in the development of small molecule Nrf2 modulators: a patent review (2012-2016).Expert Opin Ther Pat. 2017 Jul;27(7):763-785. DMER2ZQ RU https://www.ncbi.nlm.nih.gov/pubmed/28454500 DM9FRN6 DI DM9FRN6 DM9FRN6 DN 2-hydroxybenzamide derivative 2 DM9FRN6 MI TT3Z6Y9 DM9FRN6 MN Cysteines of Keap1 (KEAP1 Cysteines) DM9FRN6 MT DTT DM9FRN6 MA Modulator DM9FRN6 RN Recent progress in the development of small molecule Nrf2 modulators: a patent review (2012-2016).Expert Opin Ther Pat. 2017 Jul;27(7):763-785. DM9FRN6 RU https://www.ncbi.nlm.nih.gov/pubmed/28454500 DM9FRN6 DI DM9FRN6 DM9FRN6 DN 2-hydroxybenzamide derivative 2 DM9FRN6 MI TTA6ZN2 DM9FRN6 MN Nuclear factor erythroid 2-related factor 2 (Nrf2) DM9FRN6 MT DTT DM9FRN6 MA Activator DM9FRN6 RN Recent progress in the development of small molecule Nrf2 modulators: a patent review (2012-2016).Expert Opin Ther Pat. 2017 Jul;27(7):763-785. DM9FRN6 RU https://www.ncbi.nlm.nih.gov/pubmed/28454500 DMI4KBC DI DMI4KBC DMI4KBC DN 2-PAM derivative 1 DMI4KBC MI TT1RS9F DMI4KBC MN Acetylcholinesterase (AChE) DMI4KBC MT DTT DMI4KBC MA Reactivator DMI4KBC RN Recent advances in acetylcholinesterase Inhibitors and Reactivators: an update on the patent literature (2012-2015).Expert Opin Ther Pat. 2017 Apr;27(4):455-476. DMI4KBC RU https://www.ncbi.nlm.nih.gov/pubmed/27967267 DMQ1FAH DI DMQ1FAH DMQ1FAH DN 2-piperidine thiazole derivative 1 DMQ1FAH MI TT3M2WO DMQ1FAH MN Sphingosine kinase (SphK) DMQ1FAH MT DTT DMQ1FAH MA Inhibitor DMQ1FAH RN Sphingosine kinase inhibitors: a review of patent literature (2006-2015).Expert Opin Ther Pat. 2016 Dec;26(12):1409-1416. DMQ1FAH RU https://www.ncbi.nlm.nih.gov/pubmed/27539678 DMSJ1C0 DI DMSJ1C0 DMSJ1C0 DN 2-piperidine thiazole derivative 2 DMSJ1C0 MI TT3M2WO DMSJ1C0 MN Sphingosine kinase (SphK) DMSJ1C0 MT DTT DMSJ1C0 MA Inhibitor DMSJ1C0 RN Sphingosine kinase inhibitors: a review of patent literature (2006-2015).Expert Opin Ther Pat. 2016 Dec;26(12):1409-1416. DMSJ1C0 RU https://www.ncbi.nlm.nih.gov/pubmed/27539678 DMWXUS4 DI DMWXUS4 DMWXUS4 DN 2-pyrazinone derivative 1 DMWXUS4 MI TTPLTSQ DMWXUS4 MN Neutrophil elastase (NE) DMWXUS4 MT DTT DMWXUS4 MA Inhibitor DMWXUS4 RN Neutrophil elastase inhibitors: a patent review and potential applications for inflammatory lung diseases (2010 - 2014).Expert Opin Ther Pat. 2015;25(10):1145-58. DMWXUS4 RU https://www.ncbi.nlm.nih.gov/pubmed/26118988 DMLEH4U DI DMLEH4U DMLEH4U DN 2-pyrazinone derivative 2 DMLEH4U MI TTPLTSQ DMLEH4U MN Neutrophil elastase (NE) DMLEH4U MT DTT DMLEH4U MA Inhibitor DMLEH4U RN Neutrophil elastase inhibitors: a patent review and potential applications for inflammatory lung diseases (2010 - 2014).Expert Opin Ther Pat. 2015;25(10):1145-58. DMLEH4U RU https://www.ncbi.nlm.nih.gov/pubmed/26118988 DME5WLD DI DME5WLD DME5WLD DN 2-pyrazinone derivative 3 DME5WLD MI TTPLTSQ DME5WLD MN Neutrophil elastase (NE) DME5WLD MT DTT DME5WLD MA Inhibitor DME5WLD RN Neutrophil elastase inhibitors: a patent review and potential applications for inflammatory lung diseases (2010 - 2014).Expert Opin Ther Pat. 2015;25(10):1145-58. DME5WLD RU https://www.ncbi.nlm.nih.gov/pubmed/26118988 DMJRHS4 DI DMJRHS4 DMJRHS4 DN 2-pyrazinone derivative 4 DMJRHS4 MI TTPLTSQ DMJRHS4 MN Neutrophil elastase (NE) DMJRHS4 MT DTT DMJRHS4 MA Inhibitor DMJRHS4 RN Neutrophil elastase inhibitors: a patent review and potential applications for inflammatory lung diseases (2010 - 2014).Expert Opin Ther Pat. 2015;25(10):1145-58. DMJRHS4 RU https://www.ncbi.nlm.nih.gov/pubmed/26118988 DMBIRMA DI DMBIRMA DMBIRMA DN 2-pyrazinone derivative 5 DMBIRMA MI TTPLTSQ DMBIRMA MN Neutrophil elastase (NE) DMBIRMA MT DTT DMBIRMA MA Inhibitor DMBIRMA RN Neutrophil elastase inhibitors: a patent review and potential applications for inflammatory lung diseases (2010 - 2014).Expert Opin Ther Pat. 2015;25(10):1145-58. DMBIRMA RU https://www.ncbi.nlm.nih.gov/pubmed/26118988 DMHIEBN DI DMHIEBN DMHIEBN DN 2-pyrazinone derivative 6 DMHIEBN MI TTPLTSQ DMHIEBN MN Neutrophil elastase (NE) DMHIEBN MT DTT DMHIEBN MA Inhibitor DMHIEBN RN Neutrophil elastase inhibitors: a patent review and potential applications for inflammatory lung diseases (2010 - 2014).Expert Opin Ther Pat. 2015;25(10):1145-58. DMHIEBN RU https://www.ncbi.nlm.nih.gov/pubmed/26118988 DMTG6X9 DI DMTG6X9 DMTG6X9 DN 2-pyrazinone derivative 7 DMTG6X9 MI TTPLTSQ DMTG6X9 MN Neutrophil elastase (NE) DMTG6X9 MT DTT DMTG6X9 MA Inhibitor DMTG6X9 RN Neutrophil elastase inhibitors: a patent review and potential applications for inflammatory lung diseases (2010 - 2014).Expert Opin Ther Pat. 2015;25(10):1145-58. DMTG6X9 RU https://www.ncbi.nlm.nih.gov/pubmed/26118988 DM0DYAU DI DM0DYAU DM0DYAU DN 3-(6-allyloxy-2-naphthyl)-1-(4-piperidylmethyl)pyrazolo[3,4-d]pyrimidin-4-amine DM0DYAU MI TT42OGM DM0DYAU MN Hematopoietic cell kinase (HCK) DM0DYAU MT DTT DM0DYAU MA Inhibitor DM0DYAU RN Compositions and methods for treating toxoplasmosis, cryptosporidiosis, and other apicomplexan protozoan related diseases. US9765037. DM0DYAU RU http://www.freepatentsonline.com/US9765037.html DM9YJWU DI DM9YJWU DM9YJWU DN 3-(phenoxymethyl) benzylamine derivative 1 DM9YJWU MI TTULVH8 DM9YJWU MN Tyrosinase (TYR) DM9YJWU MT DTT DM9YJWU MA Inhibitor DM9YJWU RN Tyrosinase inhibitors: a patent review (2011-2015).Expert Opin Ther Pat. 2016;26(3):347-62. DM9YJWU RU https://www.ncbi.nlm.nih.gov/pubmed/26815044 DMGN9IX DI DMGN9IX DMGN9IX DN 3-(phenoxymethyl) benzylamine derivative 2 DMGN9IX MI TTULVH8 DMGN9IX MN Tyrosinase (TYR) DMGN9IX MT DTT DMGN9IX MA Inhibitor DMGN9IX RN Tyrosinase inhibitors: a patent review (2011-2015).Expert Opin Ther Pat. 2016;26(3):347-62. DMGN9IX RU https://www.ncbi.nlm.nih.gov/pubmed/26815044 DM43EKN DI DM43EKN DM43EKN DN 3-(phenoxymethyl) benzylamine derivative 3 DM43EKN MI TTULVH8 DM43EKN MN Tyrosinase (TYR) DM43EKN MT DTT DM43EKN MA Inhibitor DM43EKN RN Tyrosinase inhibitors: a patent review (2011-2015).Expert Opin Ther Pat. 2016;26(3):347-62. DM43EKN RU https://www.ncbi.nlm.nih.gov/pubmed/26815044 DM58X6N DI DM58X6N DM58X6N DN 3-(phenoxymethyl) benzylamine derivative 4 DM58X6N MI TTULVH8 DM58X6N MN Tyrosinase (TYR) DM58X6N MT DTT DM58X6N MA Inhibitor DM58X6N RN Tyrosinase inhibitors: a patent review (2011-2015).Expert Opin Ther Pat. 2016;26(3):347-62. DM58X6N RU https://www.ncbi.nlm.nih.gov/pubmed/26815044 DM84HG2 DI DM84HG2 DM84HG2 DN 3-(phenoxymethyl) benzylamine derivative 5 DM84HG2 MI TTULVH8 DM84HG2 MN Tyrosinase (TYR) DM84HG2 MT DTT DM84HG2 MA Inhibitor DM84HG2 RN Tyrosinase inhibitors: a patent review (2011-2015).Expert Opin Ther Pat. 2016;26(3):347-62. DM84HG2 RU https://www.ncbi.nlm.nih.gov/pubmed/26815044 DM0WBM3 DI DM0WBM3 DM0WBM3 DN 3-(phenoxymethyl) benzylamine derivative 6 DM0WBM3 MI TTULVH8 DM0WBM3 MN Tyrosinase (TYR) DM0WBM3 MT DTT DM0WBM3 MA Inhibitor DM0WBM3 RN Tyrosinase inhibitors: a patent review (2011-2015).Expert Opin Ther Pat. 2016;26(3):347-62. DM0WBM3 RU https://www.ncbi.nlm.nih.gov/pubmed/26815044 DM4O3DW DI DM4O3DW DM4O3DW DN 3,4-Dihydroxybenzaldehyde DM4O3DW MI TTGP7BY DM4O3DW MN Monoamine oxidase type B (MAO-B) DM4O3DW MT DTT DM4O3DW MA Inhibitor DM4O3DW RN Novel monoamine oxidase inhibitors: a patent review (2012 - 2014).Expert Opin Ther Pat. 2015 Jan;25(1):91-110. DM4O3DW RU https://www.ncbi.nlm.nih.gov/pubmed/25399762 DM8L0MN DI DM8L0MN DM8L0MN DN 3-acylidene-2-oxoindole derivative 1 DM8L0MN MI TT2F4OL DM8L0MN MN Tissue transglutaminase (TG2) DM8L0MN MT DTT DM8L0MN MA Inhibitor DM8L0MN RN Transglutaminase inhibitors: a patent review.Expert Opin Ther Pat. 2016;26(1):49-63. DM8L0MN RU https://www.ncbi.nlm.nih.gov/pubmed/26560530 DMJ98VG DI DMJ98VG DMJ98VG DN 3-acylidene-2-oxoindole derivative 2 DMJ98VG MI TT2F4OL DMJ98VG MN Tissue transglutaminase (TG2) DMJ98VG MT DTT DMJ98VG MA Inhibitor DMJ98VG RN Transglutaminase inhibitors: a patent review.Expert Opin Ther Pat. 2016;26(1):49-63. DMJ98VG RU https://www.ncbi.nlm.nih.gov/pubmed/26560530 DMFDURZ DI DMFDURZ DMFDURZ DN 3-amino-5-benzyl-substituted indazole derivative 1 DMFDURZ MI TTKN7QR DMFDURZ MN BDNF/NT-3 growth factors receptor (TrkB) DMFDURZ MT DTT DMFDURZ MA Inhibitor DMFDURZ RN Tropomyosin receptor kinase inhibitors: an updated patent review for 2010-2016 - Part II.Expert Opin Ther Pat. 2017 Jul;27(7):831-849. DMFDURZ RU https://www.ncbi.nlm.nih.gov/pubmed/28270021 DMFDURZ DI DMFDURZ DMFDURZ DN 3-amino-5-benzyl-substituted indazole derivative 1 DMFDURZ MI TTXABCW DMFDURZ MN NT-3 growth factor receptor (TrkC) DMFDURZ MT DTT DMFDURZ MA Inhibitor DMFDURZ RN Tropomyosin receptor kinase inhibitors: an updated patent review for 2010-2016 - Part II.Expert Opin Ther Pat. 2017 Jul;27(7):831-849. DMFDURZ RU https://www.ncbi.nlm.nih.gov/pubmed/28270021 DMFDURZ DI DMFDURZ DMFDURZ DN 3-amino-5-benzyl-substituted indazole derivative 1 DMFDURZ MI TTTDVOJ DMFDURZ MN Tropomyosin-related kinase A (TrkA) DMFDURZ MT DTT DMFDURZ MA Inhibitor DMFDURZ RN Tropomyosin receptor kinase inhibitors: an updated patent review for 2010-2016 - Part II.Expert Opin Ther Pat. 2017 Jul;27(7):831-849. DMFDURZ RU https://www.ncbi.nlm.nih.gov/pubmed/28270021 DMB6M3Y DI DMB6M3Y DMB6M3Y DN 3-benzyloxyphenyloxoacetic acid derivative 1 DMB6M3Y MI TTA592U DMB6M3Y MN Urate anion exchanger 1 (URAT1) DMB6M3Y MT DTT DMB6M3Y MA Inhibitor DMB6M3Y RN Urate transporter URAT1 inhibitors: a patent review (2012 - 2015).Expert Opin Ther Pat. 2016 Jul 30:1-10. DMB6M3Y RU https://www.ncbi.nlm.nih.gov/pubmed/27414413 DM9GPKR DI DM9GPKR DM9GPKR DN 3-Hydroxy-2-butanone DM9GPKR MI TTGP7BY DM9GPKR MN Monoamine oxidase type B (MAO-B) DM9GPKR MT DTT DM9GPKR MA Inhibitor DM9GPKR RN Novel monoamine oxidase inhibitors: a patent review (2012 - 2014).Expert Opin Ther Pat. 2015 Jan;25(1):91-110. DM9GPKR RU https://www.ncbi.nlm.nih.gov/pubmed/25399762 DMAR2OX DI DMAR2OX DMAR2OX DN 3-oxo-2,3-dihydro-1H-indazole-4-carboxamide derivative 1 DMAR2OX MI TTVDSZ0 DMAR2OX MN Poly [ADP-ribose] polymerase 1 (PARP1) DMAR2OX MT DTT DMAR2OX MA Inhibitor DMAR2OX RN PARP inhibitors as antitumor agents: a patent update (2013-2015).Expert Opin Ther Pat. 2017 Mar;27(3):363-382. DMAR2OX RU https://www.ncbi.nlm.nih.gov/pubmed/27841036 DMEVMU9 DI DMEVMU9 DMEVMU9 DN 3-oxo-2,3-dihydro-1H-indazole-4-carboxamide derivative 2 DMEVMU9 MI TTVDSZ0 DMEVMU9 MN Poly [ADP-ribose] polymerase 1 (PARP1) DMEVMU9 MT DTT DMEVMU9 MA Inhibitor DMEVMU9 RN PARP inhibitors as antitumor agents: a patent update (2013-2015).Expert Opin Ther Pat. 2017 Mar;27(3):363-382. DMEVMU9 RU https://www.ncbi.nlm.nih.gov/pubmed/27841036 DMRQ74I DI DMRQ74I DMRQ74I DN 3-oxo-2,3-dihydro-1H-indazole-4-carboxamide derivative 3 DMRQ74I MI TTVDSZ0 DMRQ74I MN Poly [ADP-ribose] polymerase 1 (PARP1) DMRQ74I MT DTT DMRQ74I MA Inhibitor DMRQ74I RN PARP inhibitors as antitumor agents: a patent update (2013-2015).Expert Opin Ther Pat. 2017 Mar;27(3):363-382. DMRQ74I RU https://www.ncbi.nlm.nih.gov/pubmed/27841036 DM8Q19H DI DM8Q19H DM8Q19H DN 3-oxo-2,3-dihydro-1H-indazole-4-carboxamide derivative 4 DM8Q19H MI TTVDSZ0 DM8Q19H MN Poly [ADP-ribose] polymerase 1 (PARP1) DM8Q19H MT DTT DM8Q19H MA Inhibitor DM8Q19H RN PARP inhibitors as antitumor agents: a patent update (2013-2015).Expert Opin Ther Pat. 2017 Mar;27(3):363-382. DM8Q19H RU https://www.ncbi.nlm.nih.gov/pubmed/27841036 DMXJ837 DI DMXJ837 DMXJ837 DN 3-oxo-2,3-dihydro-1H-indazole-4-carboxamide derivative 5 DMXJ837 MI TTVDSZ0 DMXJ837 MN Poly [ADP-ribose] polymerase 1 (PARP1) DMXJ837 MT DTT DMXJ837 MA Inhibitor DMXJ837 RN PARP inhibitors as antitumor agents: a patent update (2013-2015).Expert Opin Ther Pat. 2017 Mar;27(3):363-382. DMXJ837 RU https://www.ncbi.nlm.nih.gov/pubmed/27841036 DMXMV6N DI DMXMV6N DMXMV6N DN 3-phenyl acrylic acid derivative 1 DMXMV6N MI TTZMAO3 DMXMV6N MN Peroxisome proliferator-activated receptor gamma (PPAR-gamma) DMXMV6N MT DTT DMXMV6N MA Agonist DMXMV6N RN PPAR ligands and their therapeutic applications: a patent review (2008 - 2014).Expert Opin Ther Pat. 2015 Feb;25(2):175-91. DMXMV6N RU https://www.ncbi.nlm.nih.gov/pubmed/25416646 DMB40HC DI DMB40HC DMB40HC DN 3-phenyl isoquinolin-1(2H) derivative 1 DMB40HC MI TTVDSZ0 DMB40HC MN Poly [ADP-ribose] polymerase 1 (PARP1) DMB40HC MT DTT DMB40HC MA Inhibitor DMB40HC RN PARP inhibitors as antitumor agents: a patent update (2013-2015).Expert Opin Ther Pat. 2017 Mar;27(3):363-382. DMB40HC RU https://www.ncbi.nlm.nih.gov/pubmed/27841036 DMB40HC DI DMB40HC DMB40HC DN 3-phenyl isoquinolin-1(2H) derivative 1 DMB40HC MI TTQ4V96 DMB40HC MN Poly [ADP-ribose] polymerase 2 (PARP2) DMB40HC MT DTT DMB40HC MA Inhibitor DMB40HC RN PARP inhibitors as antitumor agents: a patent update (2013-2015).Expert Opin Ther Pat. 2017 Mar;27(3):363-382. DMB40HC RU https://www.ncbi.nlm.nih.gov/pubmed/27841036 DMB40HC DI DMB40HC DMB40HC DN 3-phenyl isoquinolin-1(2H) derivative 1 DMB40HC MI TTD8MEH DMB40HC MN Poly [ADP-ribose] polymerase 3 (PARP3) DMB40HC MT DTT DMB40HC MA Inhibitor DMB40HC RN PARP inhibitors as antitumor agents: a patent update (2013-2015).Expert Opin Ther Pat. 2017 Mar;27(3):363-382. DMB40HC RU https://www.ncbi.nlm.nih.gov/pubmed/27841036 DMA749P DI DMA749P DMA749P DN 3-phenyl isoquinolin-1(2H) derivative 2 DMA749P MI TTVDSZ0 DMA749P MN Poly [ADP-ribose] polymerase 1 (PARP1) DMA749P MT DTT DMA749P MA Inhibitor DMA749P RN PARP inhibitors as antitumor agents: a patent update (2013-2015).Expert Opin Ther Pat. 2017 Mar;27(3):363-382. DMA749P RU https://www.ncbi.nlm.nih.gov/pubmed/27841036 DMW86YI DI DMW86YI DMW86YI DN 3-phenyl propanoic derivative 1 DMW86YI MI TTHQJI6 DMW86YI MN Keap1-Nrf2[ETGE] PPI (KEAP1-Nrf2 ETGE) DMW86YI MT DTT DMW86YI MA Modulator DMW86YI RN Recent progress in the development of small molecule Nrf2 modulators: a patent review (2012-2016).Expert Opin Ther Pat. 2017 Jul;27(7):763-785. DMW86YI RU https://www.ncbi.nlm.nih.gov/pubmed/28454500 DMW86YI DI DMW86YI DMW86YI DN 3-phenyl propanoic derivative 1 DMW86YI MI TTA6ZN2 DMW86YI MN Nuclear factor erythroid 2-related factor 2 (Nrf2) DMW86YI MT DTT DMW86YI MA Inhibitor DMW86YI RN Recent progress in the development of small molecule Nrf2 modulators: a patent review (2012-2016).Expert Opin Ther Pat. 2017 Jul;27(7):763-785. DMW86YI RU https://www.ncbi.nlm.nih.gov/pubmed/28454500 DM17D30 DI DM17D30 DM17D30 DN 3-phenyl propanoic derivative 2 DM17D30 MI TTHQJI6 DM17D30 MN Keap1-Nrf2[ETGE] PPI (KEAP1-Nrf2 ETGE) DM17D30 MT DTT DM17D30 MA Modulator DM17D30 RN Recent progress in the development of small molecule Nrf2 modulators: a patent review (2012-2016).Expert Opin Ther Pat. 2017 Jul;27(7):763-785. DM17D30 RU https://www.ncbi.nlm.nih.gov/pubmed/28454500 DM17D30 DI DM17D30 DM17D30 DN 3-phenyl propanoic derivative 2 DM17D30 MI TTA6ZN2 DM17D30 MN Nuclear factor erythroid 2-related factor 2 (Nrf2) DM17D30 MT DTT DM17D30 MA Inhibitor DM17D30 RN Recent progress in the development of small molecule Nrf2 modulators: a patent review (2012-2016).Expert Opin Ther Pat. 2017 Jul;27(7):763-785. DM17D30 RU https://www.ncbi.nlm.nih.gov/pubmed/28454500 DM5GKS6 DI DM5GKS6 DM5GKS6 DN 3-phenyl propanoic derivative 3 DM5GKS6 MI TTGIZLN DM5GKS6 MN Keap1-Nrf2[dual DLG and ETGE] PPI (KEAP1-Nrf2 DLG and ETGE) DM5GKS6 MT DTT DM5GKS6 MA Modulator DM5GKS6 RN Recent progress in the development of small molecule Nrf2 modulators: a patent review (2012-2016).Expert Opin Ther Pat. 2017 Jul;27(7):763-785. DM5GKS6 RU https://www.ncbi.nlm.nih.gov/pubmed/28454500 DM5GKS6 DI DM5GKS6 DM5GKS6 DN 3-phenyl propanoic derivative 3 DM5GKS6 MI TTA6ZN2 DM5GKS6 MN Nuclear factor erythroid 2-related factor 2 (Nrf2) DM5GKS6 MT DTT DM5GKS6 MA Inhibitor DM5GKS6 RN Recent progress in the development of small molecule Nrf2 modulators: a patent review (2012-2016).Expert Opin Ther Pat. 2017 Jul;27(7):763-785. DM5GKS6 RU https://www.ncbi.nlm.nih.gov/pubmed/28454500 DM3VB6G DI DM3VB6G DM3VB6G DN 3-phenyl pyrazole derivative 1 DM3VB6G MI TTJQOD7 DM3VB6G MN 5-HT 2A receptor (HTR2A) DM3VB6G MT DTT DM3VB6G MA Antagonist DM3VB6G RN Novel serotonin receptor 2 (5-HT2R) agonists and antagonists: a patent review (2004-2014).Expert Opin Ther Pat. 2016;26(1):89-106. DM3VB6G RU https://www.ncbi.nlm.nih.gov/pubmed/26609882 DMB1JG2 DI DMB1JG2 DMB1JG2 DN 3-phenyl-5-ureidoisothiazole-4-carboximide and 3-amino-5-phenylisothiazole derivative 1 DMB1JG2 MI TTOHSBA DMB1JG2 MN Vascular endothelial growth factor A (VEGFA) DMB1JG2 MT DTT DMB1JG2 MA Inhibitor DMB1JG2 RN VEGFR-2 inhibitors and the therapeutic applications thereof: a patent review (2012-2016).Expert Opin Ther Pat. 2017 Sep;27(9):987-1004. DMB1JG2 RU https://www.ncbi.nlm.nih.gov/pubmed/28621580 DMWCT04 DI DMWCT04 DMWCT04 DN 3-substituted-1,2,4-oxadiazole derivative 1 DMWCT04 MI TT23XQV DMWCT04 MN PD-1-PD-L1 interaction (PD-1/PD-L1 PPI) DMWCT04 MT DTT DMWCT04 MA Inhibitor DMWCT04 RN A patent review on PD-1/PD-L1 antagonists: small molecules, peptides, and macrocycles (2015-2018).Expert Opin Ther Pat. 2018 Sep;28(9):665-678. DMWCT04 RU https://www.ncbi.nlm.nih.gov/pubmed/30107136 DMB3806 DI DMB3806 DMB3806 DN 3-substituted-1,2,4-oxadiazole derivative 2 DMB3806 MI TT23XQV DMB3806 MN PD-1-PD-L1 interaction (PD-1/PD-L1 PPI) DMB3806 MT DTT DMB3806 MA Inhibitor DMB3806 RN A patent review on PD-1/PD-L1 antagonists: small molecules, peptides, and macrocycles (2015-2018).Expert Opin Ther Pat. 2018 Sep;28(9):665-678. DMB3806 RU https://www.ncbi.nlm.nih.gov/pubmed/30107136 DMKEOH8 DI DMKEOH8 DMKEOH8 DN 3-substituted-2-furancarboxylic acid hydrazide derivative 1 DMKEOH8 MI TT9O6WS DMKEOH8 MN Glucagon receptor (GCGR) DMKEOH8 MT DTT DMKEOH8 MA Antagonist DMKEOH8 RN Small molecule glucagon receptor antagonists: a patent review (2011 - 2014).Expert Opin Ther Pat. 2015 Jul;25(7):819-30. DMKEOH8 RU https://www.ncbi.nlm.nih.gov/pubmed/25828189 DMLK29E DI DMLK29E DMLK29E DN 3-substituted-2-furancarboxylic acid hydrazide derivative 5 DMLK29E MI TT9O6WS DMLK29E MN Glucagon receptor (GCGR) DMLK29E MT DTT DMLK29E MA Antagonist DMLK29E RN Small molecule glucagon receptor antagonists: a patent review (2011 - 2014).Expert Opin Ther Pat. 2015 Jul;25(7):819-30. DMLK29E RU https://www.ncbi.nlm.nih.gov/pubmed/25828189 DMCJHK2 DI DMCJHK2 DMCJHK2 DN 3ts4 DMCJHK2 MI TTXLEG7 DMCJHK2 MN Matrix metalloproteinase-10 (MMP-10) DMCJHK2 MT DTT DMCJHK2 MA Inhibitor DMCJHK2 RN Pseudodipeptides as MMP inhibitors. US8691753. DMCJHK2 RU http://www.freepatentsonline.com/US8691753.html DME30O6 DI DME30O6 DME30O6 DN 4-(2-cyclohexylethoxy) aniline derivative 1 DME30O6 MI TTA6ZN2 DME30O6 MN Nuclear factor erythroid 2-related factor 2 (Nrf2) DME30O6 MT DTT DME30O6 MA Inhibitor DME30O6 RN Recent progress in the development of small molecule Nrf2 modulators: a patent review (2012-2016).Expert Opin Ther Pat. 2017 Jul;27(7):763-785. DME30O6 RU https://www.ncbi.nlm.nih.gov/pubmed/28454500 DM8F4QP DI DM8F4QP DM8F4QP DN 4-(2-cyclohexylethoxy) aniline derivative 2 DM8F4QP MI TTA6ZN2 DM8F4QP MN Nuclear factor erythroid 2-related factor 2 (Nrf2) DM8F4QP MT DTT DM8F4QP MA Inhibitor DM8F4QP RN Recent progress in the development of small molecule Nrf2 modulators: a patent review (2012-2016).Expert Opin Ther Pat. 2017 Jul;27(7):763-785. DM8F4QP RU https://www.ncbi.nlm.nih.gov/pubmed/28454500 DMJU0SO DI DMJU0SO DMJU0SO DN 4-(2-cyclohexylethoxy) aniline derivative 3 DMJU0SO MI TTA6ZN2 DMJU0SO MN Nuclear factor erythroid 2-related factor 2 (Nrf2) DMJU0SO MT DTT DMJU0SO MA Inhibitor DMJU0SO RN Recent progress in the development of small molecule Nrf2 modulators: a patent review (2012-2016).Expert Opin Ther Pat. 2017 Jul;27(7):763-785. DMJU0SO RU https://www.ncbi.nlm.nih.gov/pubmed/28454500 DMPULIC DI DMPULIC DMPULIC DN 4-(2-cyclohexylethoxy) aniline derivative 4 DMPULIC MI TTA6ZN2 DMPULIC MN Nuclear factor erythroid 2-related factor 2 (Nrf2) DMPULIC MT DTT DMPULIC MA Inhibitor DMPULIC RN Recent progress in the development of small molecule Nrf2 modulators: a patent review (2012-2016).Expert Opin Ther Pat. 2017 Jul;27(7):763-785. DMPULIC RU https://www.ncbi.nlm.nih.gov/pubmed/28454500 DM7B81V DI DM7B81V DM7B81V DN 4-(thiazol-5-yl)-pyrimidine derivative 1 DM7B81V MI TT7HF4W DM7B81V MN Cyclin-dependent kinase 2 (CDK2) DM7B81V MT DTT DM7B81V MA Inhibitor DM7B81V RN Cyclin-dependent kinase inhibitors for cancer therapy: a patent review (2009 - 2014).Expert Opin Ther Pat. 2015;25(9):953-70. DM7B81V RU https://www.ncbi.nlm.nih.gov/pubmed/26161698 DM7B81V DI DM7B81V DM7B81V DN 4-(thiazol-5-yl)-pyrimidine derivative 1 DM7B81V MI TT1LVF2 DM7B81V MN Cyclin-dependent kinase 9 (CDK9) DM7B81V MT DTT DM7B81V MA Inhibitor DM7B81V RN Cyclin-dependent kinase inhibitors for cancer therapy: a patent review (2009 - 2014).Expert Opin Ther Pat. 2015;25(9):953-70. DM7B81V RU https://www.ncbi.nlm.nih.gov/pubmed/26161698 DMMQFCN DI DMMQFCN DMMQFCN DN 4-(thiazol-5-yl)-pyrimidine derivative 2 DMMQFCN MI TTH6V3D DMMQFCN MN Cyclin-dependent kinase 1 (CDK1) DMMQFCN MT DTT DMMQFCN MA Inhibitor DMMQFCN RN Cyclin-dependent kinase inhibitors for cancer therapy: a patent review (2009 - 2014).Expert Opin Ther Pat. 2015;25(9):953-70. DMMQFCN RU https://www.ncbi.nlm.nih.gov/pubmed/26161698 DMMQFCN DI DMMQFCN DMMQFCN DN 4-(thiazol-5-yl)-pyrimidine derivative 2 DMMQFCN MI TT7HF4W DMMQFCN MN Cyclin-dependent kinase 2 (CDK2) DMMQFCN MT DTT DMMQFCN MA Inhibitor DMMQFCN RN Cyclin-dependent kinase inhibitors for cancer therapy: a patent review (2009 - 2014).Expert Opin Ther Pat. 2015;25(9):953-70. DMMQFCN RU https://www.ncbi.nlm.nih.gov/pubmed/26161698 DMMQFCN DI DMMQFCN DMMQFCN DN 4-(thiazol-5-yl)-pyrimidine derivative 2 DMMQFCN MI TTL4Q97 DMMQFCN MN Cyclin-dependent kinase 5 (CDK5) DMMQFCN MT DTT DMMQFCN MA Inhibitor DMMQFCN RN Cyclin-dependent kinase inhibitors for cancer therapy: a patent review (2009 - 2014).Expert Opin Ther Pat. 2015;25(9):953-70. DMMQFCN RU https://www.ncbi.nlm.nih.gov/pubmed/26161698 DMMQFCN DI DMMQFCN DMMQFCN DN 4-(thiazol-5-yl)-pyrimidine derivative 2 DMMQFCN MI TT1LVF2 DMMQFCN MN Cyclin-dependent kinase 9 (CDK9) DMMQFCN MT DTT DMMQFCN MA Inhibitor DMMQFCN RN Cyclin-dependent kinase inhibitors for cancer therapy: a patent review (2009 - 2014).Expert Opin Ther Pat. 2015;25(9):953-70. DMMQFCN RU https://www.ncbi.nlm.nih.gov/pubmed/26161698 DMCISHW DI DMCISHW DMCISHW DN 4,5,6,7-tetrahydrofuro[3,4-c]pyridine-1(3H)-one derivative 1 DMCISHW MI TTV1C0Z DMCISHW MN Neuropeptide S receptor (NPSR) DMCISHW MT DTT DMCISHW MA Antagonist DMCISHW RN Neuropeptide S receptor ligands: a patent review (2005-2016).Expert Opin Ther Pat. 2017 Mar;27(3):347-362. DMCISHW RU https://www.ncbi.nlm.nih.gov/pubmed/27788040 DMPTRQD DI DMPTRQD DMPTRQD DN 4,5,6,7-tetrahydrofuro[3,4-c]pyridine-1(3H)-one derivative 2 DMPTRQD MI TTV1C0Z DMPTRQD MN Neuropeptide S receptor (NPSR) DMPTRQD MT DTT DMPTRQD MA Antagonist DMPTRQD RN Neuropeptide S receptor ligands: a patent review (2005-2016).Expert Opin Ther Pat. 2017 Mar;27(3):347-362. DMPTRQD RU https://www.ncbi.nlm.nih.gov/pubmed/27788040 DMFOBM9 DI DMFOBM9 DMFOBM9 DN 4,5,6,7-tetrahydrofuro[3,4-c]pyridine-1(3H)-one derivative 3 DMFOBM9 MI TTV1C0Z DMFOBM9 MN Neuropeptide S receptor (NPSR) DMFOBM9 MT DTT DMFOBM9 MA Antagonist DMFOBM9 RN Neuropeptide S receptor ligands: a patent review (2005-2016).Expert Opin Ther Pat. 2017 Mar;27(3):347-362. DMFOBM9 RU https://www.ncbi.nlm.nih.gov/pubmed/27788040 DM6MCBU DI DM6MCBU DM6MCBU DN 4,5,6,7-tetrahydrofuro[3,4-c]pyridine-1(3H)-one derivative 4 DM6MCBU MI TTV1C0Z DM6MCBU MN Neuropeptide S receptor (NPSR) DM6MCBU MT DTT DM6MCBU MA Antagonist DM6MCBU RN Neuropeptide S receptor ligands: a patent review (2005-2016).Expert Opin Ther Pat. 2017 Mar;27(3):347-362. DM6MCBU RU https://www.ncbi.nlm.nih.gov/pubmed/27788040 DMMELYI DI DMMELYI DMMELYI DN 4-amino-3,5-di-substituted-thiazole derivative 1 DMMELYI MI TT7HF4W DMMELYI MN Cyclin-dependent kinase 2 (CDK2) DMMELYI MT DTT DMMELYI MA Inhibitor DMMELYI RN Cyclin-dependent kinase inhibitors for cancer therapy: a patent review (2009 - 2014).Expert Opin Ther Pat. 2015;25(9):953-70. DMMELYI RU https://www.ncbi.nlm.nih.gov/pubmed/26161698 DMEMYDZ DI DMEMYDZ DMEMYDZ DN 4-aryl quinol derivative 1 DMEMYDZ MI TTR7UJ3 DMEMYDZ MN Cytoplasmic thioredoxin reductase (TXNRD1) DMEMYDZ MT DTT DMEMYDZ MA Inhibitor DMEMYDZ RN Thioredoxin reductase inhibitors: a patent review.Expert Opin Ther Pat. 2017 May;27(5):547-556. DMEMYDZ RU https://www.ncbi.nlm.nih.gov/pubmed/27977313 DM7TW5Z DI DM7TW5Z DM7TW5Z DN 4-aryl quinol derivative 2 DM7TW5Z MI TTR7UJ3 DM7TW5Z MN Cytoplasmic thioredoxin reductase (TXNRD1) DM7TW5Z MT DTT DM7TW5Z MA Inhibitor DM7TW5Z RN Thioredoxin reductase inhibitors: a patent review.Expert Opin Ther Pat. 2017 May;27(5):547-556. DM7TW5Z RU https://www.ncbi.nlm.nih.gov/pubmed/27977313 DM05V8Q DI DM05V8Q DM05V8Q DN 4-aryl quinol derivative 3 DM05V8Q MI TTR7UJ3 DM05V8Q MN Cytoplasmic thioredoxin reductase (TXNRD1) DM05V8Q MT DTT DM05V8Q MA Inhibitor DM05V8Q RN Thioredoxin reductase inhibitors: a patent review.Expert Opin Ther Pat. 2017 May;27(5):547-556. DM05V8Q RU https://www.ncbi.nlm.nih.gov/pubmed/27977313 DM5IWX2 DI DM5IWX2 DM5IWX2 DN 4-aryl quinol derivative 4 DM5IWX2 MI TTR7UJ3 DM5IWX2 MN Cytoplasmic thioredoxin reductase (TXNRD1) DM5IWX2 MT DTT DM5IWX2 MA Inhibitor DM5IWX2 RN Thioredoxin reductase inhibitors: a patent review.Expert Opin Ther Pat. 2017 May;27(5):547-556. DM5IWX2 RU https://www.ncbi.nlm.nih.gov/pubmed/27977313 DMWB2YX DI DMWB2YX DMWB2YX DN 4-aryl quinol derivative 5 DMWB2YX MI TTR7UJ3 DMWB2YX MN Cytoplasmic thioredoxin reductase (TXNRD1) DMWB2YX MT DTT DMWB2YX MA Inhibitor DMWB2YX RN Thioredoxin reductase inhibitors: a patent review.Expert Opin Ther Pat. 2017 May;27(5):547-556. DMWB2YX RU https://www.ncbi.nlm.nih.gov/pubmed/27977313 DMC3KTB DI DMC3KTB DMC3KTB DN 4-aryl quinol derivative 7 DMC3KTB MI TTR7UJ3 DMC3KTB MN Cytoplasmic thioredoxin reductase (TXNRD1) DMC3KTB MT DTT DMC3KTB MA Inhibitor DMC3KTB RN Thioredoxin reductase inhibitors: a patent review.Expert Opin Ther Pat. 2017 May;27(5):547-556. DMC3KTB RU https://www.ncbi.nlm.nih.gov/pubmed/27977313 DMZDUNT DI DMZDUNT DMZDUNT DN 4-benzylidene-1-(cyclobutylo)piperidine derivative 1 DMZDUNT MI TT9JNIC DMZDUNT MN Histamine H3 receptor (H3R) DMZDUNT MT DTT DMZDUNT RN Progress in the development of histamine H3 receptor antagonists/inverse agonists: a patent review (2013-2017).Expert Opin Ther Pat. 2018 Mar;28(3):175-196. DMZDUNT RU https://www.ncbi.nlm.nih.gov/pubmed/29334795 DMM9I1R DI DMM9I1R DMM9I1R DN 4-Carboxamido-isoindolinone derivative 1 DMM9I1R MI TTVDSZ0 DMM9I1R MN Poly [ADP-ribose] polymerase 1 (PARP1) DMM9I1R MT DTT DMM9I1R MA Inhibitor DMM9I1R RN PARP inhibitors as antitumor agents: a patent update (2013-2015).Expert Opin Ther Pat. 2017 Mar;27(3):363-382. DMM9I1R RU https://www.ncbi.nlm.nih.gov/pubmed/27841036 DM3EHSN DI DM3EHSN DM3EHSN DN 4-Carboxamido-isoindolinone derivative 2 DM3EHSN MI TTVDSZ0 DM3EHSN MN Poly [ADP-ribose] polymerase 1 (PARP1) DM3EHSN MT DTT DM3EHSN MA Inhibitor DM3EHSN RN PARP inhibitors as antitumor agents: a patent update (2013-2015).Expert Opin Ther Pat. 2017 Mar;27(3):363-382. DM3EHSN RU https://www.ncbi.nlm.nih.gov/pubmed/27841036 DM43YA0 DI DM43YA0 DM43YA0 DN 4-Carboxamido-isoindolinone derivative 3 DM43YA0 MI TTVDSZ0 DM43YA0 MN Poly [ADP-ribose] polymerase 1 (PARP1) DM43YA0 MT DTT DM43YA0 MA Inhibitor DM43YA0 RN PARP inhibitors as antitumor agents: a patent update (2013-2015).Expert Opin Ther Pat. 2017 Mar;27(3):363-382. DM43YA0 RU https://www.ncbi.nlm.nih.gov/pubmed/27841036 DMTGEFW DI DMTGEFW DMTGEFW DN 4-Carboxamido-isoindolinone derivative 4 DMTGEFW MI TTVDSZ0 DMTGEFW MN Poly [ADP-ribose] polymerase 1 (PARP1) DMTGEFW MT DTT DMTGEFW MA Inhibitor DMTGEFW RN PARP inhibitors as antitumor agents: a patent update (2013-2015).Expert Opin Ther Pat. 2017 Mar;27(3):363-382. DMTGEFW RU https://www.ncbi.nlm.nih.gov/pubmed/27841036 DMIYVOC DI DMIYVOC DMIYVOC DN 4-Carboxamido-isoindolinone derivative 5 DMIYVOC MI TTVDSZ0 DMIYVOC MN Poly [ADP-ribose] polymerase 1 (PARP1) DMIYVOC MT DTT DMIYVOC MA Inhibitor DMIYVOC RN PARP inhibitors as antitumor agents: a patent update (2013-2015).Expert Opin Ther Pat. 2017 Mar;27(3):363-382. DMIYVOC RU https://www.ncbi.nlm.nih.gov/pubmed/27841036 DM9L5KO DI DM9L5KO DM9L5KO DN 4-Hydroxy-2,5-dimethyl-3(2H)-furanone DM9L5KO MI TTGP7BY DM9L5KO MN Monoamine oxidase type B (MAO-B) DM9L5KO MT DTT DM9L5KO MA Inhibitor DM9L5KO RN Novel monoamine oxidase inhibitors: a patent review (2012 - 2014).Expert Opin Ther Pat. 2015 Jan;25(1):91-110. DM9L5KO RU https://www.ncbi.nlm.nih.gov/pubmed/25399762 DM471P5 DI DM471P5 DM471P5 DN 4-hydroxybenzaldehyde DM471P5 MI TTT2LD9 DM471P5 MN GABA transaminase (ABAT) DM471P5 MT DTT DM471P5 MA Inhibitor DM471P5 RN Inactivation of GABA transaminase by 3-chloro-1-(4-hydroxyphenyl)propan-1-one. Bioorg Med Chem Lett. 2009 Feb 1;19(3):731-4. DM471P5 RU https://pubmed.ncbi.nlm.nih.gov/19138517 DM471P5 DI DM471P5 DM471P5 DN 4-hydroxybenzaldehyde DM471P5 MI TTGP7BY DM471P5 MN Monoamine oxidase type B (MAO-B) DM471P5 MT DTT DM471P5 MA Inhibitor DM471P5 RN Novel monoamine oxidase inhibitors: a patent review (2012 - 2014).Expert Opin Ther Pat. 2015 Jan;25(1):91-110. DM471P5 RU https://www.ncbi.nlm.nih.gov/pubmed/25399762 DM3WQNY DI DM3WQNY DM3WQNY DN 4-Hydroxybenzoicacid DM3WQNY MI TTGP7BY DM3WQNY MN Monoamine oxidase type B (MAO-B) DM3WQNY MT DTT DM3WQNY MA Inhibitor DM3WQNY RN Novel monoamine oxidase inhibitors: a patent review (2012 - 2014).Expert Opin Ther Pat. 2015 Jan;25(1):91-110. DM3WQNY RU https://www.ncbi.nlm.nih.gov/pubmed/25399762 DMKDZMQ DI DMKDZMQ DMKDZMQ DN 4-Hydroxybenzylalcohol DMKDZMQ MI TTGP7BY DMKDZMQ MN Monoamine oxidase type B (MAO-B) DMKDZMQ MT DTT DMKDZMQ MA Inhibitor DMKDZMQ RN Novel monoamine oxidase inhibitors: a patent review (2012 - 2014).Expert Opin Ther Pat. 2015 Jan;25(1):91-110. DMKDZMQ RU https://www.ncbi.nlm.nih.gov/pubmed/25399762 DMN6GTZ DI DMN6GTZ DMN6GTZ DN 4-Methoxybenzaldehyde DMN6GTZ MI TTGP7BY DMN6GTZ MN Monoamine oxidase type B (MAO-B) DMN6GTZ MT DTT DMN6GTZ MA Inhibitor DMN6GTZ RN Novel monoamine oxidase inhibitors: a patent review (2012 - 2014).Expert Opin Ther Pat. 2015 Jan;25(1):91-110. DMN6GTZ RU https://www.ncbi.nlm.nih.gov/pubmed/25399762 DMNTOZV DI DMNTOZV DMNTOZV DN 4-methyl-4,5-dihydro-1H-pyrazole-3-carboxamide derivative 1 DMNTOZV MI TT6OEDT DMNTOZV MN Cannabinoid receptor 1 (CB1) DMNTOZV MT DTT DMNTOZV MA Antagonist DMNTOZV RN A comprehensive patents review on cannabinoid 1 receptor antagonists as antiobesity agents. Expert Opin Ther Pat. 2015 Oct;25(10):1093-116. DMNTOZV RU https://pubmed.ncbi.nlm.nih.gov/26161824 DMWFHKR DI DMWFHKR DMWFHKR DN 4-oxadiazole derivative 1 DMWFHKR MI TTO9X1H DMWFHKR MN 5-HT 7 receptor (HTR7) DMWFHKR MT DTT DMWFHKR MA Inhibitor DMWFHKR RN Acyltransferase inhibitors: a patent review (2010-present).Expert Opin Ther Pat. 2015 Feb;25(2):145-58. DMWFHKR RU https://www.ncbi.nlm.nih.gov/pubmed/25470667 DMN37BI DI DMN37BI DMN37BI DN 4-PAM derivative 1 DMN37BI MI TT1RS9F DMN37BI MN Acetylcholinesterase (AChE) DMN37BI MT DTT DMN37BI MA Reactivator DMN37BI RN Recent advances in acetylcholinesterase Inhibitors and Reactivators: an update on the patent literature (2012-2015).Expert Opin Ther Pat. 2017 Apr;27(4):455-476. DMN37BI RU https://www.ncbi.nlm.nih.gov/pubmed/27967267 DMMBUGK DI DMMBUGK DMMBUGK DN 4-pyridone derivative 1 DMMBUGK MI TTPLTSQ DMMBUGK MN Neutrophil elastase (NE) DMMBUGK MT DTT DMMBUGK MA Inhibitor DMMBUGK RN Neutrophil elastase inhibitors: a patent review and potential applications for inflammatory lung diseases (2010 - 2014).Expert Opin Ther Pat. 2015;25(10):1145-58. DMMBUGK RU https://www.ncbi.nlm.nih.gov/pubmed/26118988 DMS1O0G DI DMS1O0G DMS1O0G DN 4-pyridone derivative 2 DMS1O0G MI TTPLTSQ DMS1O0G MN Neutrophil elastase (NE) DMS1O0G MT DTT DMS1O0G MA Inhibitor DMS1O0G RN Neutrophil elastase inhibitors: a patent review and potential applications for inflammatory lung diseases (2010 - 2014).Expert Opin Ther Pat. 2015;25(10):1145-58. DMS1O0G RU https://www.ncbi.nlm.nih.gov/pubmed/26118988 DMN2B87 DI DMN2B87 DMN2B87 DN 5-azolone derivative 1 DMN2B87 MI TTG5QB7 DMN2B87 MN Calpain-2 (CAPN2) DMN2B87 MT DTT DMN2B87 MA Inhibitor DMN2B87 RN An updated patent review of calpain inhibitors (2012 - 2014).Expert Opin Ther Pat. 2015 Jan;25(1):17-31. DMN2B87 RU https://www.ncbi.nlm.nih.gov/pubmed/25399719 DMHXKFB DI DMHXKFB DMHXKFB DN 5-fluoro-N-(pyridin-2-yl)pyridin-2-amine derivative 1 DMHXKFB MI TT7HF4W DMHXKFB MN Cyclin-dependent kinase 2 (CDK2) DMHXKFB MT DTT DMHXKFB MA Inhibitor DMHXKFB RN Cyclin-dependent kinase inhibitors for cancer therapy: a patent review (2009 - 2014).Expert Opin Ther Pat. 2015;25(9):953-70. DMHXKFB RU https://www.ncbi.nlm.nih.gov/pubmed/26161698 DMHXKFB DI DMHXKFB DMHXKFB DN 5-fluoro-N-(pyridin-2-yl)pyridin-2-amine derivative 1 DMHXKFB MI TT1LVF2 DMHXKFB MN Cyclin-dependent kinase 9 (CDK9) DMHXKFB MT DTT DMHXKFB MA Inhibitor DMHXKFB RN Cyclin-dependent kinase inhibitors for cancer therapy: a patent review (2009 - 2014).Expert Opin Ther Pat. 2015;25(9):953-70. DMHXKFB RU https://www.ncbi.nlm.nih.gov/pubmed/26161698 DMOIKB3 DI DMOIKB3 DMOIKB3 DN 5-Hydrazino-1H-tetrazole DMOIKB3 MI TTLQUZS DMOIKB3 MN Cystathionine gamma-lyase (CTH) DMOIKB3 MT DTT DMOIKB3 MA Inhibitor DMOIKB3 RN Cystathionine--lyase (CSE) inhibitors. US9725426. DMOIKB3 RU http://www.freepatentsonline.com/US9725426.html DM0VEBI DI DM0VEBI DM0VEBI DN 6,6-fused nitrogenous heterocyclic compound 1 DM0VEBI MI TT3PJMV DM0VEBI MN Tyrosine-protein kinase ABL1 (ABL) DM0VEBI MT DTT DM0VEBI MA Inhibitor DM0VEBI RN Bcr-Abl tyrosine kinase inhibitors: a patent review.Expert Opin Ther Pat. 2015 Apr;25(4):397-412. DM0VEBI RU https://www.ncbi.nlm.nih.gov/pubmed/25656651 DMB1EAW DI DMB1EAW DMB1EAW DN 6,6-fused nitrogenous heterocyclic compound 2 DMB1EAW MI TT3PJMV DMB1EAW MN Tyrosine-protein kinase ABL1 (ABL) DMB1EAW MT DTT DMB1EAW MA Inhibitor DMB1EAW RN Bcr-Abl tyrosine kinase inhibitors: a patent review.Expert Opin Ther Pat. 2015 Apr;25(4):397-412. DMB1EAW RU https://www.ncbi.nlm.nih.gov/pubmed/25656651 DMX3VCO DI DMX3VCO DMX3VCO DN 6,6-fused nitrogenous heterocyclic compound 3 DMX3VCO MI TT3PJMV DMX3VCO MN Tyrosine-protein kinase ABL1 (ABL) DMX3VCO MT DTT DMX3VCO MA Inhibitor DMX3VCO RN Bcr-Abl tyrosine kinase inhibitors: a patent review.Expert Opin Ther Pat. 2015 Apr;25(4):397-412. DMX3VCO RU https://www.ncbi.nlm.nih.gov/pubmed/25656651 DMJL1MB DI DMJL1MB DMJL1MB DN 67S DMJL1MB MI TTECBXN DMJL1MB MN Oxysterols receptor LXR-alpha (NR1H3) DMJL1MB MT DTT DMJL1MB MA Inhibitor DMJL1MB RN Piperazine derivatives as liver X receptor modulators. US10144715. DMJL1MB RU http://www.freepatentsonline.com/US10144715.html DMTXGYS DI DMTXGYS DMTXGYS DN 6-aryl-imidazopyridine and 6-aryl-triazolopyridine carboxamide analog 1 DMTXGYS MI TTHS256 DMTXGYS MN Metabotropic glutamate receptor 5 (mGluR5) DMTXGYS MT DTT DMTXGYS MA Modulator DMTXGYS RN mGlu5 negative allosteric modulators: a patent review (2013 - 2016).Expert Opin Ther Pat. 2017 Jun;27(6):691-706. DMTXGYS RU https://www.ncbi.nlm.nih.gov/pubmed/28067079 DMFKTBM DI DMFKTBM DMFKTBM DN 6-aryl-imidazopyridine and 6-aryl-triazolopyridine carboxamide analog 2 DMFKTBM MI TTHS256 DMFKTBM MN Metabotropic glutamate receptor 5 (mGluR5) DMFKTBM MT DTT DMFKTBM MA Modulator DMFKTBM RN mGlu5 negative allosteric modulators: a patent review (2013 - 2016).Expert Opin Ther Pat. 2017 Jun;27(6):691-706. DMFKTBM RU https://www.ncbi.nlm.nih.gov/pubmed/28067079 DMXMTLP DI DMXMTLP DMXMTLP DN 6-aryl-imidazopyridine and 6-aryl-triazolopyridine carboxamide analog 3 DMXMTLP MI TTHS256 DMXMTLP MN Metabotropic glutamate receptor 5 (mGluR5) DMXMTLP MT DTT DMXMTLP MA Modulator DMXMTLP RN mGlu5 negative allosteric modulators: a patent review (2013 - 2016).Expert Opin Ther Pat. 2017 Jun;27(6):691-706. DMXMTLP RU https://www.ncbi.nlm.nih.gov/pubmed/28067079 DMN082G DI DMN082G DMN082G DN 6EP DMN082G MI TTIG67W DMN082G MN Lysine-specific demethylase 5A (KDM5A) DMN082G MT DTT DMN082G MA Inhibitor DMN082G RN Histone demethylase inhibitors. US9714230. DMN082G RU http://www.freepatentsonline.com/US9714230.html DMV5XR7 DI DMV5XR7 DMV5XR7 DN 6-Phenylquinazolin-4-amine DMV5XR7 MI TT6NI13 DMV5XR7 MN MEK kinase kinase 4 (MAP4K4) DMV5XR7 MT DTT DMV5XR7 MA Inhibitor DMV5XR7 RN Aminoquinazoline and pyridopyrimidine derivatives. US9592235. DMV5XR7 RU http://www.freepatentsonline.com/US9592235.html DMQL5B7 DI DMQL5B7 DMQL5B7 DN 7-azaindole derivative 1 DMQL5B7 MI TT0K6EO DMQL5B7 MN Stress-activated protein kinase JNK1 (JNK1) DMQL5B7 MT DTT DMQL5B7 MA Inhibitor DMQL5B7 RN c-Jun N-terminal kinase inhibitors: a patent review (2010 - 2014).Expert Opin Ther Pat. 2015;25(8):849-72. DMQL5B7 RU https://www.ncbi.nlm.nih.gov/pubmed/25991433 DMQL5B7 DI DMQL5B7 DMQL5B7 DN 7-azaindole derivative 1 DMQL5B7 MI TTHS0U8 DMQL5B7 MN Stress-activated protein kinase JNK2 (JNK2) DMQL5B7 MT DTT DMQL5B7 MA Inhibitor DMQL5B7 RN c-Jun N-terminal kinase inhibitors: a patent review (2010 - 2014).Expert Opin Ther Pat. 2015;25(8):849-72. DMQL5B7 RU https://www.ncbi.nlm.nih.gov/pubmed/25991433 DMQL5B7 DI DMQL5B7 DMQL5B7 DN 7-azaindole derivative 1 DMQL5B7 MI TT056SO DMQL5B7 MN Stress-activated protein kinase JNK3 (JNK3) DMQL5B7 MT DTT DMQL5B7 MA Inhibitor DMQL5B7 RN c-Jun N-terminal kinase inhibitors: a patent review (2010 - 2014).Expert Opin Ther Pat. 2015;25(8):849-72. DMQL5B7 RU https://www.ncbi.nlm.nih.gov/pubmed/25991433 DMZRM2Q DI DMZRM2Q DMZRM2Q DN 7-azaindole derivative 2 DMZRM2Q MI TT0K6EO DMZRM2Q MN Stress-activated protein kinase JNK1 (JNK1) DMZRM2Q MT DTT DMZRM2Q MA Inhibitor DMZRM2Q RN c-Jun N-terminal kinase inhibitors: a patent review (2010 - 2014).Expert Opin Ther Pat. 2015;25(8):849-72. DMZRM2Q RU https://www.ncbi.nlm.nih.gov/pubmed/25991433 DMZRM2Q DI DMZRM2Q DMZRM2Q DN 7-azaindole derivative 2 DMZRM2Q MI TTHS0U8 DMZRM2Q MN Stress-activated protein kinase JNK2 (JNK2) DMZRM2Q MT DTT DMZRM2Q MA Inhibitor DMZRM2Q RN c-Jun N-terminal kinase inhibitors: a patent review (2010 - 2014).Expert Opin Ther Pat. 2015;25(8):849-72. DMZRM2Q RU https://www.ncbi.nlm.nih.gov/pubmed/25991433 DMZRM2Q DI DMZRM2Q DMZRM2Q DN 7-azaindole derivative 2 DMZRM2Q MI TT056SO DMZRM2Q MN Stress-activated protein kinase JNK3 (JNK3) DMZRM2Q MT DTT DMZRM2Q MA Inhibitor DMZRM2Q RN c-Jun N-terminal kinase inhibitors: a patent review (2010 - 2014).Expert Opin Ther Pat. 2015;25(8):849-72. DMZRM2Q RU https://www.ncbi.nlm.nih.gov/pubmed/25991433 DMQ7BV4 DI DMQ7BV4 DMQ7BV4 DN 7-azaindole derivative 3 DMQ7BV4 MI TT0K6EO DMQ7BV4 MN Stress-activated protein kinase JNK1 (JNK1) DMQ7BV4 MT DTT DMQ7BV4 MA Inhibitor DMQ7BV4 RN c-Jun N-terminal kinase inhibitors: a patent review (2010 - 2014).Expert Opin Ther Pat. 2015;25(8):849-72. DMQ7BV4 RU https://www.ncbi.nlm.nih.gov/pubmed/25991433 DMQ7BV4 DI DMQ7BV4 DMQ7BV4 DN 7-azaindole derivative 3 DMQ7BV4 MI TTHS0U8 DMQ7BV4 MN Stress-activated protein kinase JNK2 (JNK2) DMQ7BV4 MT DTT DMQ7BV4 MA Inhibitor DMQ7BV4 RN c-Jun N-terminal kinase inhibitors: a patent review (2010 - 2014).Expert Opin Ther Pat. 2015;25(8):849-72. DMQ7BV4 RU https://www.ncbi.nlm.nih.gov/pubmed/25991433 DMQ7BV4 DI DMQ7BV4 DMQ7BV4 DN 7-azaindole derivative 3 DMQ7BV4 MI TT056SO DMQ7BV4 MN Stress-activated protein kinase JNK3 (JNK3) DMQ7BV4 MT DTT DMQ7BV4 MA Inhibitor DMQ7BV4 RN c-Jun N-terminal kinase inhibitors: a patent review (2010 - 2014).Expert Opin Ther Pat. 2015;25(8):849-72. DMQ7BV4 RU https://www.ncbi.nlm.nih.gov/pubmed/25991433 DMW3EMH DI DMW3EMH DMW3EMH DN 7-azaindole derivative 4 DMW3EMH MI TT056SO DMW3EMH MN Stress-activated protein kinase JNK3 (JNK3) DMW3EMH MT DTT DMW3EMH MA Inhibitor DMW3EMH RN c-Jun N-terminal kinase inhibitors: a patent review (2010 - 2014).Expert Opin Ther Pat. 2015;25(8):849-72. DMW3EMH RU https://www.ncbi.nlm.nih.gov/pubmed/25991433 DMV3H98 DI DMV3H98 DMV3H98 DN 7-azaindole derivative 5 DMV3H98 MI TT0K6EO DMV3H98 MN Stress-activated protein kinase JNK1 (JNK1) DMV3H98 MT DTT DMV3H98 MA Inhibitor DMV3H98 RN c-Jun N-terminal kinase inhibitors: a patent review (2010 - 2014).Expert Opin Ther Pat. 2015;25(8):849-72. DMV3H98 RU https://www.ncbi.nlm.nih.gov/pubmed/25991433 DMV3H98 DI DMV3H98 DMV3H98 DN 7-azaindole derivative 5 DMV3H98 MI TTHS0U8 DMV3H98 MN Stress-activated protein kinase JNK2 (JNK2) DMV3H98 MT DTT DMV3H98 MA Inhibitor DMV3H98 RN c-Jun N-terminal kinase inhibitors: a patent review (2010 - 2014).Expert Opin Ther Pat. 2015;25(8):849-72. DMV3H98 RU https://www.ncbi.nlm.nih.gov/pubmed/25991433 DMV3H98 DI DMV3H98 DMV3H98 DN 7-azaindole derivative 5 DMV3H98 MI TT056SO DMV3H98 MN Stress-activated protein kinase JNK3 (JNK3) DMV3H98 MT DTT DMV3H98 MA Inhibitor DMV3H98 RN c-Jun N-terminal kinase inhibitors: a patent review (2010 - 2014).Expert Opin Ther Pat. 2015;25(8):849-72. DMV3H98 RU https://www.ncbi.nlm.nih.gov/pubmed/25991433 DM8X5GP DI DM8X5GP DM8X5GP DN 7-azaindole derivative 6 DM8X5GP MI TT056SO DM8X5GP MN Stress-activated protein kinase JNK3 (JNK3) DM8X5GP MT DTT DM8X5GP MA Inhibitor DM8X5GP RN c-Jun N-terminal kinase inhibitors: a patent review (2010 - 2014).Expert Opin Ther Pat. 2015;25(8):849-72. DM8X5GP RU https://www.ncbi.nlm.nih.gov/pubmed/25991433 DMB1WQZ DI DMB1WQZ DMB1WQZ DN 7-azaindole derivative 7 DMB1WQZ MI TT056SO DMB1WQZ MN Stress-activated protein kinase JNK3 (JNK3) DMB1WQZ MT DTT DMB1WQZ MA Inhibitor DMB1WQZ RN c-Jun N-terminal kinase inhibitors: a patent review (2010 - 2014).Expert Opin Ther Pat. 2015;25(8):849-72. DMB1WQZ RU https://www.ncbi.nlm.nih.gov/pubmed/25991433 DMO1920 DI DMO1920 DMO1920 DN 7-azaindole derivative 8 DMO1920 MI TTVDSZ0 DMO1920 MN Poly [ADP-ribose] polymerase 1 (PARP1) DMO1920 MT DTT DMO1920 MA Inhibitor DMO1920 RN PARP inhibitors as antitumor agents: a patent update (2013-2015).Expert Opin Ther Pat. 2017 Mar;27(3):363-382. DMO1920 RU https://www.ncbi.nlm.nih.gov/pubmed/27841036 DMAY4G1 DI DMAY4G1 DMAY4G1 DN 7-azaindole derivative 9 DMAY4G1 MI TTEBCY8 DMAY4G1 MN Poly [ADP-ribose] polymerase (PARP) DMAY4G1 MT DTT DMAY4G1 MA Inhibitor DMAY4G1 RN PARP inhibitors as antitumor agents: a patent update (2013-2015).Expert Opin Ther Pat. 2017 Mar;27(3):363-382. DMAY4G1 RU https://www.ncbi.nlm.nih.gov/pubmed/27841036 DMP04Z6 DI DMP04Z6 DMP04Z6 DN 879325-11-8 DMP04Z6 MI TTOJ9QL DMP04Z6 MN Endoplasmic reticulum to nucleus signaling 1 (ERN1) DMP04Z6 MT DTT DMP04Z6 MA Inhibitor DMP04Z6 RN IRE-1 inhibitors. US9040714. DMP04Z6 RU http://www.freepatentsonline.com/US9040714.html DMPQ2L9 DI DMPQ2L9 DMPQ2L9 DN 936563-93-8 DMPQ2L9 MI TTX6F0Q DMPQ2L9 MN Tyrosine-protein kinase CSK (CSK) DMPQ2L9 MT DTT DMPQ2L9 MA Inhibitor DMPQ2L9 RN Inhibitors of bruton's tyrosine kinase for the treatment of solid tumors. US9278100. DMPQ2L9 RU http://www.freepatentsonline.com/US9278100.html DM9ESPR DI DM9ESPR DM9ESPR DN A1-10436 DM9ESPR MI TT0C8BY DM9ESPR MN Plasma retinol-binding protein (RBP4) DM9ESPR MT DTT DM9ESPR MA Inhibitor DM9ESPR RN Derivatives of N-acyl-N-phenylpiperazine useful (inter alia) for the prophylaxis or treatment of diabetes. US8853215. DM9ESPR RU http://www.freepatentsonline.com/US8853215.html DMJD1S6 DI DMJD1S6 DMJD1S6 DN A1-10438 DMJD1S6 MI TT0C8BY DMJD1S6 MN Plasma retinol-binding protein (RBP4) DMJD1S6 MT DTT DMJD1S6 MA Inhibitor DMJD1S6 RN Derivatives of N-acyl-N-phenylpiperazine useful (inter alia) for the prophylaxis or treatment of diabetes. US8853215. DMJD1S6 RU http://www.freepatentsonline.com/US8853215.html DMFWYKE DI DMFWYKE DMFWYKE DN AC1LCOK0 DMFWYKE MI TT3RMNA DMFWYKE MN Chymotrypsin-C (CLCR) DMFWYKE MT DTT DMFWYKE MA Inhibitor DMFWYKE RN Benzoxazinone derivatives for treatment of skin diseases. US9695194. DMFWYKE RU http://www.freepatentsonline.com/US9695194.html DMKTMCH DI DMKTMCH DMKTMCH DN AC1LDDOQ DMKTMCH MI TT3ZS42 DMKTMCH MN Phosphodiesterase 1B (PDE1B) DMKTMCH MT DTT DMKTMCH MA Inhibitor DMKTMCH RN Substituted thiophene- and furan-fused azolopyrimidine-5-(6H)-one compounds. US10092575. DMKTMCH RU http://www.freepatentsonline.com/US10092575.html DMPOR3G DI DMPOR3G DMPOR3G DN AC1LE05K DMPOR3G MI TTOJ9QL DMPOR3G MN Endoplasmic reticulum to nucleus signaling 1 (ERN1) DMPOR3G MT DTT DMPOR3G MA Inhibitor DMPOR3G RN IRE-1 inhibitors. US9693992. DMPOR3G RU http://www.freepatentsonline.com/US9693992.html DMXI3O0 DI DMXI3O0 DMXI3O0 DN AC1LFGWU DMXI3O0 MI TTLKF5M DMXI3O0 MN NAD-dependent deacetylase sirtuin-2 (SIRT2) DMXI3O0 MT DTT DMXI3O0 MA Inhibitor DMXI3O0 RN Small molecule activators of NRF2 pathway. US9737525. DMXI3O0 RU http://www.freepatentsonline.com/US9737525.html DMEVBZW DI DMEVBZW DMEVBZW DN AC1LFXA6 DMEVBZW MI TT25MVL DMEVBZW MN Serine protease hepsin (HPN) DMEVBZW MT DTT DMEVBZW MA Inhibitor DMEVBZW RN Hepsin inhibitors. US9182402. DMEVBZW RU http://www.freepatentsonline.com/US9182402.html DM9Q0EC DI DM9Q0EC DM9Q0EC DN AC1LJNG0 DM9Q0EC MI TT1NFO3 DM9Q0EC MN Bacterial Nicotinate-nucleotide adenylyltransferase (Bact nadD) DM9Q0EC MT DTT DM9Q0EC MA Inhibitor DM9Q0EC RN Targeting NAD biosynthesis in bacterial pathogens. US8785499. DM9Q0EC RU http://www.freepatentsonline.com/US8785499.html DMVX9NK DI DMVX9NK DMVX9NK DN AC1LOJYQ DMVX9NK MI TTLKF5M DMVX9NK MN NAD-dependent deacetylase sirtuin-2 (SIRT2) DMVX9NK MT DTT DMVX9NK MA Inhibitor DMVX9NK RN Small molecule activators of NRF2 pathway. US9737525. DMVX9NK RU http://www.freepatentsonline.com/US9737525.html DMEW5LD DI DMEW5LD DMEW5LD DN AC1M1SP5 DMEW5LD MI TTIS4OW DMEW5LD MN Phosphodiesterase 8 (PDE8) DMEW5LD MT DTT DMEW5LD MA Inhibitor DMEW5LD RN Inhibitors of phosphodiesterase 11 (PDE11). US9173884. DMEW5LD RU http://www.freepatentsonline.com/US9173884.html DM6293C DI DM6293C DM6293C DN AC1MOZOL DM6293C MI TT3ZS42 DM6293C MN Phosphodiesterase 1B (PDE1B) DM6293C MT DTT DM6293C MA Inhibitor DM6293C RN Inhibitors of phosphodiesterase 11 (PDE11). US9173884. DM6293C RU http://www.freepatentsonline.com/US9173884.html DMO4YAB DI DMO4YAB DMO4YAB DN Acrylamide compound 1 DMO4YAB MI TT9JNIC DMO4YAB MN Histamine H3 receptor (H3R) DMO4YAB MT DTT DMO4YAB RN Progress in the development of histamine H3 receptor antagonists/inverse agonists: a patent review (2013-2017).Expert Opin Ther Pat. 2018 Mar;28(3):175-196. DMO4YAB RU https://www.ncbi.nlm.nih.gov/pubmed/29334795 DM7EOG4 DI DM7EOG4 DM7EOG4 DN Acrylamide compound 2 DM7EOG4 MI TT9JNIC DM7EOG4 MN Histamine H3 receptor (H3R) DM7EOG4 MT DTT DM7EOG4 RN Progress in the development of histamine H3 receptor antagonists/inverse agonists: a patent review (2013-2017).Expert Opin Ther Pat. 2018 Mar;28(3):175-196. DM7EOG4 RU https://www.ncbi.nlm.nih.gov/pubmed/29334795 DM7JARB DI DM7JARB DM7JARB DN Acrylamide compound 3 DM7JARB MI TT9JNIC DM7JARB MN Histamine H3 receptor (H3R) DM7JARB MT DTT DM7JARB RN Progress in the development of histamine H3 receptor antagonists/inverse agonists: a patent review (2013-2017).Expert Opin Ther Pat. 2018 Mar;28(3):175-196. DM7JARB RU https://www.ncbi.nlm.nih.gov/pubmed/29334795 DMZL6D8 DI DMZL6D8 DMZL6D8 DN Acrylamide compound 4 DMZL6D8 MI TT9JNIC DMZL6D8 MN Histamine H3 receptor (H3R) DMZL6D8 MT DTT DMZL6D8 RN Progress in the development of histamine H3 receptor antagonists/inverse agonists: a patent review (2013-2017).Expert Opin Ther Pat. 2018 Mar;28(3):175-196. DMZL6D8 RU https://www.ncbi.nlm.nih.gov/pubmed/29334795 DMXTUE1 DI DMXTUE1 DMXTUE1 DN Acyl oxymethyl acrylamide ester derivative 1 DMXTUE1 MI TTR7UJ3 DMXTUE1 MN Cytoplasmic thioredoxin reductase (TXNRD1) DMXTUE1 MT DTT DMXTUE1 MA Inhibitor DMXTUE1 RN Thioredoxin reductase inhibitors: a patent review.Expert Opin Ther Pat. 2017 May;27(5):547-556. DMXTUE1 RU https://www.ncbi.nlm.nih.gov/pubmed/27977313 DMXTUE1 DI DMXTUE1 DMXTUE1 DN Acyl oxymethyl acrylamide ester derivative 1 DMXTUE1 MI TTEP6RV DMXTUE1 MN Glutathione reductase (GR) DMXTUE1 MT DTT DMXTUE1 MA Inhibitor DMXTUE1 RN Thioredoxin reductase inhibitors: a patent review.Expert Opin Ther Pat. 2017 May;27(5):547-556. DMXTUE1 RU https://www.ncbi.nlm.nih.gov/pubmed/27977313 DMU8OIL DI DMU8OIL DMU8OIL DN Acyl oxymethyl acrylamide ester derivative 2 DMU8OIL MI TTR7UJ3 DMU8OIL MN Cytoplasmic thioredoxin reductase (TXNRD1) DMU8OIL MT DTT DMU8OIL MA Inhibitor DMU8OIL RN Thioredoxin reductase inhibitors: a patent review.Expert Opin Ther Pat. 2017 May;27(5):547-556. DMU8OIL RU https://www.ncbi.nlm.nih.gov/pubmed/27977313 DMX9J1C DI DMX9J1C DMX9J1C DN Acyl piperidine derivative 1 DMX9J1C MI TTZJYKH DMX9J1C MN Indoleamine 2,3-dioxygenase 1 (IDO1) DMX9J1C MT DTT DMX9J1C MA Inhibitor DMX9J1C RN A patent review of IDO1 inhibitors for cancer.Expert Opin Ther Pat. 2018 Apr;28(4):317-330. DMX9J1C RU https://www.ncbi.nlm.nih.gov/pubmed/29473428 DM2FUIB DI DM2FUIB DM2FUIB DN Acyl piperidine derivative 2 DM2FUIB MI TT2F4OL DM2FUIB MN Tissue transglutaminase (TG2) DM2FUIB MT DTT DM2FUIB MA Inhibitor DM2FUIB RN Transglutaminase inhibitors: a patent review.Expert Opin Ther Pat. 2016;26(1):49-63. DM2FUIB RU https://www.ncbi.nlm.nih.gov/pubmed/26560530 DMIDUB4 DI DMIDUB4 DMIDUB4 DN Acyl piperidine derivative 3 DMIDUB4 MI TT2F4OL DMIDUB4 MN Tissue transglutaminase (TG2) DMIDUB4 MT DTT DMIDUB4 MA Inhibitor DMIDUB4 RN Transglutaminase inhibitors: a patent review.Expert Opin Ther Pat. 2016;26(1):49-63. DMIDUB4 RU https://www.ncbi.nlm.nih.gov/pubmed/26560530 DMA1RVN DI DMA1RVN DMA1RVN DN Ac-YVAD-cmk DMA1RVN MI TTCQIBE DMA1RVN MN Caspase-1 (CASP1) DMA1RVN MT DTT DMA1RVN MA Inhibitor DMA1RVN RN Caspase inhibitors: a review of recently patented compounds (2013-2015).Expert Opin Ther Pat. 2018 Jan;28(1):47-59. DMA1RVN RU https://www.ncbi.nlm.nih.gov/pubmed/28885866 DM7K256 DI DM7K256 DM7K256 DN Ac-YVAD-FMK DM7K256 MI TTCQIBE DM7K256 MN Caspase-1 (CASP1) DM7K256 MT DTT DM7K256 MA Inhibitor DM7K256 RN Caspase inhibitors: a review of recently patented compounds (2013-2015).Expert Opin Ther Pat. 2018 Jan;28(1):47-59. DM7K256 RU https://www.ncbi.nlm.nih.gov/pubmed/28885866 DMD94MP DI DMD94MP DMD94MP DN Adamantyl derivative 1 DMD94MP MI TTMSFAW DMD94MP MN Cannabinoid receptor 2 (CB2) DMD94MP MT DTT DMD94MP MA Agonist DMD94MP RN Cannabinoid receptor 2 (CB2) agonists and antagonists: a patent update.Expert Opin Ther Pat. 2016 Jul;26(7):843-56. DMD94MP RU https://www.ncbi.nlm.nih.gov/pubmed/27215781 DM2L83Y DI DM2L83Y DM2L83Y DN AGGGWZCOULSEER-PYUWXLGESA-N DM2L83Y MI TT5U49F DM2L83Y MN PRKACA messenger RNA (PRKACA mRNA) DM2L83Y MT DTT DM2L83Y MA Inhibitor DM2L83Y RN Purine derivatives. US8846696. DM2L83Y RU http://www.freepatentsonline.com/US8846696.html DM0P2U3 DI DM0P2U3 DM0P2U3 DN AKOS003197197 DM0P2U3 MI TTLQUZS DM0P2U3 MN Cystathionine gamma-lyase (CTH) DM0P2U3 MT DTT DM0P2U3 MA Inhibitor DM0P2U3 RN Cystathionine--lyase (CSE) inhibitors. US9725426. DM0P2U3 RU http://www.freepatentsonline.com/US9725426.html DMWHN1O DI DMWHN1O DMWHN1O DN AKOS020330481 DMWHN1O MI TTIG67W DMWHN1O MN Lysine-specific demethylase 5A (KDM5A) DMWHN1O MT DTT DMWHN1O MA Inhibitor DMWHN1O RN Histone demethylase inhibitors. US9611221. DMWHN1O RU http://www.freepatentsonline.com/US9611221.html DMNIE4M DI DMNIE4M DMNIE4M DN AKOS020330656 DMNIE4M MI TTIG67W DMNIE4M MN Lysine-specific demethylase 5A (KDM5A) DMNIE4M MT DTT DMNIE4M MA Inhibitor DMNIE4M RN Histone demethylase inhibitors. US10179769. DMNIE4M RU http://www.freepatentsonline.com/US10179769.html DMPXAGD DI DMPXAGD DMPXAGD DN Alkaloid derivative 4 DMPXAGD MI TTUX68I DMPXAGD MN Hypoxia-inducible factor 1 (HIF-1) DMPXAGD MT DTT DMPXAGD MA Inhibitor DMPXAGD RN Hypoxia-inducible factor (HIF) inhibitors: a patent survey (2011-2015).Expert Opin Ther Pat. 2016;26(3):309-22. DMPXAGD RU https://www.ncbi.nlm.nih.gov/pubmed/26882240 DMW57UB DI DMW57UB DMW57UB DN Alkyl mannoside derivative 1 DMW57UB MI TTTCRU2 DMW57UB MN Bacterial Fimbrin D-mannose adhesin (Bact FimH) DMW57UB MT DTT DMW57UB MA Antagonist DMW57UB RN Mannose-derived FimH antagonists: a promising anti-virulence therapeutic strategy for urinary tract infections and Crohn's disease.Expert Opin Ther Pat. 2016;26(2):175-97. DMW57UB RU https://www.ncbi.nlm.nih.gov/pubmed/26651364 DMHD51F DI DMHD51F DMHD51F DN Alkyl mannoside derivative 10 DMHD51F MI TTTCRU2 DMHD51F MN Bacterial Fimbrin D-mannose adhesin (Bact FimH) DMHD51F MT DTT DMHD51F MA Antagonist DMHD51F RN Mannose-derived FimH antagonists: a promising anti-virulence therapeutic strategy for urinary tract infections and Crohn's disease.Expert Opin Ther Pat. 2016;26(2):175-97. DMHD51F RU https://www.ncbi.nlm.nih.gov/pubmed/26651364 DMMNZ2U DI DMMNZ2U DMMNZ2U DN Alkyl mannoside derivative 11 DMMNZ2U MI TTTCRU2 DMMNZ2U MN Bacterial Fimbrin D-mannose adhesin (Bact FimH) DMMNZ2U MT DTT DMMNZ2U MA Antagonist DMMNZ2U RN Mannose-derived FimH antagonists: a promising anti-virulence therapeutic strategy for urinary tract infections and Crohn's disease.Expert Opin Ther Pat. 2016;26(2):175-97. DMMNZ2U RU https://www.ncbi.nlm.nih.gov/pubmed/26651364 DMX1OZF DI DMX1OZF DMX1OZF DN Alkyl mannoside derivative 12 DMX1OZF MI TTTCRU2 DMX1OZF MN Bacterial Fimbrin D-mannose adhesin (Bact FimH) DMX1OZF MT DTT DMX1OZF MA Antagonist DMX1OZF RN Mannose-derived FimH antagonists: a promising anti-virulence therapeutic strategy for urinary tract infections and Crohn's disease.Expert Opin Ther Pat. 2016;26(2):175-97. DMX1OZF RU https://www.ncbi.nlm.nih.gov/pubmed/26651364 DMNQUKP DI DMNQUKP DMNQUKP DN Alkyl mannoside derivative 2 DMNQUKP MI TTTCRU2 DMNQUKP MN Bacterial Fimbrin D-mannose adhesin (Bact FimH) DMNQUKP MT DTT DMNQUKP MA Antagonist DMNQUKP RN Mannose-derived FimH antagonists: a promising anti-virulence therapeutic strategy for urinary tract infections and Crohn's disease.Expert Opin Ther Pat. 2016;26(2):175-97. DMNQUKP RU https://www.ncbi.nlm.nih.gov/pubmed/26651364 DML2B58 DI DML2B58 DML2B58 DN Alkyl mannoside derivative 3 DML2B58 MI TTTCRU2 DML2B58 MN Bacterial Fimbrin D-mannose adhesin (Bact FimH) DML2B58 MT DTT DML2B58 MA Antagonist DML2B58 RN Mannose-derived FimH antagonists: a promising anti-virulence therapeutic strategy for urinary tract infections and Crohn's disease.Expert Opin Ther Pat. 2016;26(2):175-97. DML2B58 RU https://www.ncbi.nlm.nih.gov/pubmed/26651364 DMZR71O DI DMZR71O DMZR71O DN Alkyl mannoside derivative 4 DMZR71O MI TTTCRU2 DMZR71O MN Bacterial Fimbrin D-mannose adhesin (Bact FimH) DMZR71O MT DTT DMZR71O MA Antagonist DMZR71O RN Mannose-derived FimH antagonists: a promising anti-virulence therapeutic strategy for urinary tract infections and Crohn's disease.Expert Opin Ther Pat. 2016;26(2):175-97. DMZR71O RU https://www.ncbi.nlm.nih.gov/pubmed/26651364 DM04ZJ2 DI DM04ZJ2 DM04ZJ2 DN Alkyl mannoside derivative 5 DM04ZJ2 MI TTTCRU2 DM04ZJ2 MN Bacterial Fimbrin D-mannose adhesin (Bact FimH) DM04ZJ2 MT DTT DM04ZJ2 MA Antagonist DM04ZJ2 RN Mannose-derived FimH antagonists: a promising anti-virulence therapeutic strategy for urinary tract infections and Crohn's disease.Expert Opin Ther Pat. 2016;26(2):175-97. DM04ZJ2 RU https://www.ncbi.nlm.nih.gov/pubmed/26651364 DMCIV32 DI DMCIV32 DMCIV32 DN Alkyl mannoside derivative 6 DMCIV32 MI TTTCRU2 DMCIV32 MN Bacterial Fimbrin D-mannose adhesin (Bact FimH) DMCIV32 MT DTT DMCIV32 MA Antagonist DMCIV32 RN Mannose-derived FimH antagonists: a promising anti-virulence therapeutic strategy for urinary tract infections and Crohn's disease.Expert Opin Ther Pat. 2016;26(2):175-97. DMCIV32 RU https://www.ncbi.nlm.nih.gov/pubmed/26651364 DMBLSH1 DI DMBLSH1 DMBLSH1 DN Alkyl mannoside derivative 7 DMBLSH1 MI TTTCRU2 DMBLSH1 MN Bacterial Fimbrin D-mannose adhesin (Bact FimH) DMBLSH1 MT DTT DMBLSH1 MA Antagonist DMBLSH1 RN Mannose-derived FimH antagonists: a promising anti-virulence therapeutic strategy for urinary tract infections and Crohn's disease.Expert Opin Ther Pat. 2016;26(2):175-97. DMBLSH1 RU https://www.ncbi.nlm.nih.gov/pubmed/26651364 DMZP1JT DI DMZP1JT DMZP1JT DN Alkyl mannoside derivative 8 DMZP1JT MI TTTCRU2 DMZP1JT MN Bacterial Fimbrin D-mannose adhesin (Bact FimH) DMZP1JT MT DTT DMZP1JT MA Antagonist DMZP1JT RN Mannose-derived FimH antagonists: a promising anti-virulence therapeutic strategy for urinary tract infections and Crohn's disease.Expert Opin Ther Pat. 2016;26(2):175-97. DMZP1JT RU https://www.ncbi.nlm.nih.gov/pubmed/26651364 DMV1QUX DI DMV1QUX DMV1QUX DN Alkyl mannoside derivative 9 DMV1QUX MI TTTCRU2 DMV1QUX MN Bacterial Fimbrin D-mannose adhesin (Bact FimH) DMV1QUX MT DTT DMV1QUX MA Antagonist DMV1QUX RN Mannose-derived FimH antagonists: a promising anti-virulence therapeutic strategy for urinary tract infections and Crohn's disease.Expert Opin Ther Pat. 2016;26(2):175-97. DMV1QUX RU https://www.ncbi.nlm.nih.gov/pubmed/26651364 DM06U3J DI DM06U3J DM06U3J DN Alkyl sulfone derivative 1 DM06U3J MI TT7HF4W DM06U3J MN Cyclin-dependent kinase 2 (CDK2) DM06U3J MT DTT DM06U3J MA Inhibitor DM06U3J RN Cyclin-dependent kinase inhibitors for cancer therapy: a patent review (2009 - 2014).Expert Opin Ther Pat. 2015;25(9):953-70. DM06U3J RU https://www.ncbi.nlm.nih.gov/pubmed/26161698 DM06U3J DI DM06U3J DM06U3J DN Alkyl sulfone derivative 1 DM06U3J MI TT1LVF2 DM06U3J MN Cyclin-dependent kinase 9 (CDK9) DM06U3J MT DTT DM06U3J MA Inhibitor DM06U3J RN Cyclin-dependent kinase inhibitors for cancer therapy: a patent review (2009 - 2014).Expert Opin Ther Pat. 2015;25(9):953-70. DM06U3J RU https://www.ncbi.nlm.nih.gov/pubmed/26161698 DMEZDQ4 DI DMEZDQ4 DMEZDQ4 DN Alkynyl-heteroaromatic ring compound 1 DMEZDQ4 MI TTIV39N DMEZDQ4 MN Fusion protein Bcr-Abl T315I mutant (Bcr-Abl T315I) DMEZDQ4 MT DTT DMEZDQ4 MA Inhibitor DMEZDQ4 RN Bcr-Abl tyrosine kinase inhibitors: a patent review.Expert Opin Ther Pat. 2015 Apr;25(4):397-412. DMEZDQ4 RU https://www.ncbi.nlm.nih.gov/pubmed/25656651 DMK7DJ2 DI DMK7DJ2 DMK7DJ2 DN Alkynyl-substituted pyrimidinyl-pyrrole derivative 1 DMK7DJ2 MI TTRMX3V DMK7DJ2 MN Janus kinase 2 (JAK-2) DMK7DJ2 MT DTT DMK7DJ2 MA Inhibitor DMK7DJ2 RN Inhibitors of JAK-family kinases: an update on the patent literature 2013-2015, part 2.Expert Opin Ther Pat. 2017 Feb;27(2):145-161. DMK7DJ2 RU https://www.ncbi.nlm.nih.gov/pubmed/27774822 DMK7DJ2 DI DMK7DJ2 DMK7DJ2 DN Alkynyl-substituted pyrimidinyl-pyrrole derivative 1 DMK7DJ2 MI TT1RWNJ DMK7DJ2 MN Tyrosine-protein kinase Lyn (JTK8) DMK7DJ2 MT DTT DMK7DJ2 MA Inhibitor DMK7DJ2 RN Inhibitors of JAK-family kinases: an update on the patent literature 2013-2015, part 2.Expert Opin Ther Pat. 2017 Feb;27(2):145-161. DMK7DJ2 RU https://www.ncbi.nlm.nih.gov/pubmed/27774822 DMWX0QK DI DMWX0QK DMWX0QK DN Alpha-substituted pirinixic acid and pirinixic acid ester derivative 1 DMWX0QK MI TTYLQ8V DMWX0QK MN Prostaglandin E synthase (PTGES) DMWX0QK MT DTT DMWX0QK MA Inhibitor DMWX0QK RN Microsomal prostaglandin E2 synthase-1 inhibitors: a patent review.Expert Opin Ther Pat. 2017 Sep;27(9):1047-1059. DMWX0QK RU https://www.ncbi.nlm.nih.gov/pubmed/28627961 DMO64LA DI DMO64LA DMO64LA DN Amide derivative 1 DMO64LA MI TT6OEDT DMO64LA MN Cannabinoid receptor 1 (CB1) DMO64LA MT DTT DMO64LA MA Antagonist DMO64LA RN A comprehensive patents review on cannabinoid 1 receptor antagonists as antiobesity agents. Expert Opin Ther Pat. 2015 Oct;25(10):1093-116. DMO64LA RU https://pubmed.ncbi.nlm.nih.gov/26161824 DMBKIR0 DI DMBKIR0 DMBKIR0 DN Amide derivative 2 DMBKIR0 MI TTZJYKH DMBKIR0 MN Indoleamine 2,3-dioxygenase 1 (IDO1) DMBKIR0 MT DTT DMBKIR0 MA Inhibitor DMBKIR0 RN A patent review of IDO1 inhibitors for cancer.Expert Opin Ther Pat. 2018 Apr;28(4):317-330. DMBKIR0 RU https://www.ncbi.nlm.nih.gov/pubmed/29473428 DM1FUOY DI DM1FUOY DM1FUOY DN amidepsines DM1FUOY MI TTF8P9I DM1FUOY MN Diacylglycerol acyltransferase 1 (DGAT1) DM1FUOY MT DTT DM1FUOY MA Inhibitor DM1FUOY RN Acyltransferase inhibitors: a patent review (2010-present).Expert Opin Ther Pat. 2015 Feb;25(2):145-58. DM1FUOY RU https://www.ncbi.nlm.nih.gov/pubmed/25470667 DMUPT9A DI DMUPT9A DMUPT9A DN Amidine compound 1 DMUPT9A MI TTQR74A DMUPT9A MN Proteinase activated receptor 2 (PAR2) DMUPT9A MT DTT DMUPT9A MA Antagonist DMUPT9A RN Protease activated receptor 2 (PAR2) modulators: a patent review (2010-2015).Expert Opin Ther Pat. 2016;26(4):471-83. DMUPT9A RU https://www.ncbi.nlm.nih.gov/pubmed/26936077 DM2UWSX DI DM2UWSX DM2UWSX DN Amidine compound 2 DM2UWSX MI TTQR74A DM2UWSX MN Proteinase activated receptor 2 (PAR2) DM2UWSX MT DTT DM2UWSX MA Antagonist DM2UWSX RN Protease activated receptor 2 (PAR2) modulators: a patent review (2010-2015).Expert Opin Ther Pat. 2016;26(4):471-83. DM2UWSX RU https://www.ncbi.nlm.nih.gov/pubmed/26936077 DMV0QJ4 DI DMV0QJ4 DMV0QJ4 DN Amidine compound 3 DMV0QJ4 MI TTQR74A DMV0QJ4 MN Proteinase activated receptor 2 (PAR2) DMV0QJ4 MT DTT DMV0QJ4 MA Antagonist DMV0QJ4 RN Protease activated receptor 2 (PAR2) modulators: a patent review (2010-2015).Expert Opin Ther Pat. 2016;26(4):471-83. DMV0QJ4 RU https://www.ncbi.nlm.nih.gov/pubmed/26936077 DM9EGVN DI DM9EGVN DM9EGVN DN Amidine compound 4 DM9EGVN MI TTQR74A DM9EGVN MN Proteinase activated receptor 2 (PAR2) DM9EGVN MT DTT DM9EGVN MA Antagonist DM9EGVN RN Protease activated receptor 2 (PAR2) modulators: a patent review (2010-2015).Expert Opin Ther Pat. 2016;26(4):471-83. DM9EGVN RU https://www.ncbi.nlm.nih.gov/pubmed/26936077 DMMN8OY DI DMMN8OY DMMN8OY DN Amidine compound 5 DMMN8OY MI TTQR74A DMMN8OY MN Proteinase activated receptor 2 (PAR2) DMMN8OY MT DTT DMMN8OY MA Antagonist DMMN8OY RN Protease activated receptor 2 (PAR2) modulators: a patent review (2010-2015).Expert Opin Ther Pat. 2016;26(4):471-83. DMMN8OY RU https://www.ncbi.nlm.nih.gov/pubmed/26936077 DMFNK0L DI DMFNK0L DMFNK0L DN Amidine compound 6 DMFNK0L MI TTQR74A DMFNK0L MN Proteinase activated receptor 2 (PAR2) DMFNK0L MT DTT DMFNK0L MA Antagonist DMFNK0L RN Protease activated receptor 2 (PAR2) modulators: a patent review (2010-2015).Expert Opin Ther Pat. 2016;26(4):471-83. DMFNK0L RU https://www.ncbi.nlm.nih.gov/pubmed/26936077 DM8STUQ DI DM8STUQ DM8STUQ DN Amidine oxime derivative 1 DM8STUQ MI TT1RS9F DM8STUQ MN Acetylcholinesterase (AChE) DM8STUQ MT DTT DM8STUQ MA Reactivator DM8STUQ RN Recent advances in acetylcholinesterase Inhibitors and Reactivators: an update on the patent literature (2012-2015).Expert Opin Ther Pat. 2017 Apr;27(4):455-476. DM8STUQ RU https://www.ncbi.nlm.nih.gov/pubmed/27967267 DM5X92S DI DM5X92S DM5X92S DN Amidopyrazole derivative 1 DM5X92S MI TTKFVXR DM5X92S MN Renal carcinoma antigen NY-REN-64 (IRAK-4) DM5X92S MT DTT DM5X92S MA Inhibitor DM5X92S RN Inhibitors of interleukin-1 receptor-associated kinase 4 (IRAK4): a patent review (2012-2015).Expert Opin Ther Pat. 2016 Aug;26(8):917-32. DM5X92S RU https://www.ncbi.nlm.nih.gov/pubmed/27310003 DMGO9WY DI DMGO9WY DMGO9WY DN Amidopyrazole derivative 2 DMGO9WY MI TTKFVXR DMGO9WY MN Renal carcinoma antigen NY-REN-64 (IRAK-4) DMGO9WY MT DTT DMGO9WY MA Inhibitor DMGO9WY RN Inhibitors of interleukin-1 receptor-associated kinase 4 (IRAK4): a patent review (2012-2015).Expert Opin Ther Pat. 2016 Aug;26(8):917-32. DMGO9WY RU https://www.ncbi.nlm.nih.gov/pubmed/27310003 DMTHS3L DI DMTHS3L DMTHS3L DN Amidopyrazole derivative 3 DMTHS3L MI TTKFVXR DMTHS3L MN Renal carcinoma antigen NY-REN-64 (IRAK-4) DMTHS3L MT DTT DMTHS3L MA Inhibitor DMTHS3L RN Inhibitors of interleukin-1 receptor-associated kinase 4 (IRAK4): a patent review (2012-2015).Expert Opin Ther Pat. 2016 Aug;26(8):917-32. DMTHS3L RU https://www.ncbi.nlm.nih.gov/pubmed/27310003 DMF6N7Z DI DMF6N7Z DMF6N7Z DN Amidopyrazole derivative 4 DMF6N7Z MI TTKFVXR DMF6N7Z MN Renal carcinoma antigen NY-REN-64 (IRAK-4) DMF6N7Z MT DTT DMF6N7Z MA Inhibitor DMF6N7Z RN Inhibitors of interleukin-1 receptor-associated kinase 4 (IRAK4): a patent review (2012-2015).Expert Opin Ther Pat. 2016 Aug;26(8):917-32. DMF6N7Z RU https://www.ncbi.nlm.nih.gov/pubmed/27310003 DMJ37V2 DI DMJ37V2 DMJ37V2 DN Amidopyrazole derivative 5 DMJ37V2 MI TTKFVXR DMJ37V2 MN Renal carcinoma antigen NY-REN-64 (IRAK-4) DMJ37V2 MT DTT DMJ37V2 MA Inhibitor DMJ37V2 RN Inhibitors of interleukin-1 receptor-associated kinase 4 (IRAK4): a patent review (2012-2015).Expert Opin Ther Pat. 2016 Aug;26(8):917-32. DMJ37V2 RU https://www.ncbi.nlm.nih.gov/pubmed/27310003 DMJZ1IG DI DMJZ1IG DMJZ1IG DN Amidopyrazole derivative 6 DMJZ1IG MI TTKFVXR DMJZ1IG MN Renal carcinoma antigen NY-REN-64 (IRAK-4) DMJZ1IG MT DTT DMJZ1IG MA Inhibitor DMJZ1IG RN Inhibitors of interleukin-1 receptor-associated kinase 4 (IRAK4): a patent review (2012-2015).Expert Opin Ther Pat. 2016 Aug;26(8):917-32. DMJZ1IG RU https://www.ncbi.nlm.nih.gov/pubmed/27310003 DMQVZY5 DI DMQVZY5 DMQVZY5 DN Aminoarylpyridine derivative 1 DMQVZY5 MI TT1LVF2 DMQVZY5 MN Cyclin-dependent kinase 9 (CDK9) DMQVZY5 MT DTT DMQVZY5 MA Inhibitor DMQVZY5 RN Cyclin-dependent kinase inhibitors for cancer therapy: a patent review (2009 - 2014).Expert Opin Ther Pat. 2015;25(9):953-70. DMQVZY5 RU https://www.ncbi.nlm.nih.gov/pubmed/26161698 DMNI0M1 DI DMNI0M1 DMNI0M1 DN Aminoazetidine derivative 1 DMNI0M1 MI TT6OEDT DMNI0M1 MN Cannabinoid receptor 1 (CB1) DMNI0M1 MT DTT DMNI0M1 MA Antagonist DMNI0M1 RN A comprehensive patents review on cannabinoid 1 receptor antagonists as antiobesity agents. Expert Opin Ther Pat. 2015 Oct;25(10):1093-116. DMNI0M1 RU https://pubmed.ncbi.nlm.nih.gov/26161824 DMHSNA5 DI DMHSNA5 DMHSNA5 DN Aminoazetidine derivative 2 DMHSNA5 MI TT6OEDT DMHSNA5 MN Cannabinoid receptor 1 (CB1) DMHSNA5 MT DTT DMHSNA5 MA Antagonist DMHSNA5 RN A comprehensive patents review on cannabinoid 1 receptor antagonists as antiobesity agents. Expert Opin Ther Pat. 2015 Oct;25(10):1093-116. DMHSNA5 RU https://pubmed.ncbi.nlm.nih.gov/26161824 DMOQHA9 DI DMOQHA9 DMOQHA9 DN Aminoazetidine derivative 3 DMOQHA9 MI TT6OEDT DMOQHA9 MN Cannabinoid receptor 1 (CB1) DMOQHA9 MT DTT DMOQHA9 MA Antagonist DMOQHA9 RN A comprehensive patents review on cannabinoid 1 receptor antagonists as antiobesity agents. Expert Opin Ther Pat. 2015 Oct;25(10):1093-116. DMOQHA9 RU https://pubmed.ncbi.nlm.nih.gov/26161824 DM50E4Y DI DM50E4Y DM50E4Y DN Aminoazetidine derivative 4 DM50E4Y MI TT6OEDT DM50E4Y MN Cannabinoid receptor 1 (CB1) DM50E4Y MT DTT DM50E4Y MA Antagonist DM50E4Y RN A comprehensive patents review on cannabinoid 1 receptor antagonists as antiobesity agents. Expert Opin Ther Pat. 2015 Oct;25(10):1093-116. DM50E4Y RU https://pubmed.ncbi.nlm.nih.gov/26161824 DMYPD4Z DI DMYPD4Z DMYPD4Z DN Aminoazetidine derivative 5 DMYPD4Z MI TT6OEDT DMYPD4Z MN Cannabinoid receptor 1 (CB1) DMYPD4Z MT DTT DMYPD4Z MA Antagonist DMYPD4Z RN A comprehensive patents review on cannabinoid 1 receptor antagonists as antiobesity agents. Expert Opin Ther Pat. 2015 Oct;25(10):1093-116. DMYPD4Z RU https://pubmed.ncbi.nlm.nih.gov/26161824 DM3LNQG DI DM3LNQG DM3LNQG DN Aminoazetidine derivative 7 DM3LNQG MI TT6OEDT DM3LNQG MN Cannabinoid receptor 1 (CB1) DM3LNQG MT DTT DM3LNQG MA Antagonist DM3LNQG RN A comprehensive patents review on cannabinoid 1 receptor antagonists as antiobesity agents. Expert Opin Ther Pat. 2015 Oct;25(10):1093-116. DM3LNQG RU https://pubmed.ncbi.nlm.nih.gov/26161824 DMLOIHD DI DMLOIHD DMLOIHD DN Aminoazetidine derivative 8 DMLOIHD MI TT6OEDT DMLOIHD MN Cannabinoid receptor 1 (CB1) DMLOIHD MT DTT DMLOIHD MA Antagonist DMLOIHD RN A comprehensive patents review on cannabinoid 1 receptor antagonists as antiobesity agents. Expert Opin Ther Pat. 2015 Oct;25(10):1093-116. DMLOIHD RU https://pubmed.ncbi.nlm.nih.gov/26161824 DMUASHT DI DMUASHT DMUASHT DN Aminoazetidine derivative 9 DMUASHT MI TT6OEDT DMUASHT MN Cannabinoid receptor 1 (CB1) DMUASHT MT DTT DMUASHT MA Antagonist DMUASHT RN A comprehensive patents review on cannabinoid 1 receptor antagonists as antiobesity agents. Expert Opin Ther Pat. 2015 Oct;25(10):1093-116. DMUASHT RU https://pubmed.ncbi.nlm.nih.gov/26161824 DM1RQIU DI DM1RQIU DM1RQIU DN Aminobenzoxazole analog 1 DM1RQIU MI TT473XN DM1RQIU MN P2X purinoceptor 7 (P2RX7) DM1RQIU MT DTT DM1RQIU MA Antagonist DM1RQIU RN P2X7 receptor antagonists: a patent review (2010-2015).Expert Opin Ther Pat. 2017 Mar;27(3):257-267. DM1RQIU RU https://www.ncbi.nlm.nih.gov/pubmed/27724045 DMYHRJD DI DMYHRJD DMYHRJD DN Aminocyclopentenone compound 1 DMYHRJD MI TTRA6BO DMYHRJD MN Bromodomain-containing protein 4 (BRD4) DMYHRJD MT DTT DMYHRJD MA Inhibitor DMYHRJD RN BET inhibitors in cancer therapeutics: a patent review.Expert Opin Ther Pat. 2016;26(4):505-22. DMYHRJD RU https://www.ncbi.nlm.nih.gov/pubmed/26924192 DMAYHNI DI DMAYHNI DMAYHNI DN Aminocyclopentenone compound 2 DMAYHNI MI TTRA6BO DMAYHNI MN Bromodomain-containing protein 4 (BRD4) DMAYHNI MT DTT DMAYHNI MA Inhibitor DMAYHNI RN BET inhibitors in cancer therapeutics: a patent review.Expert Opin Ther Pat. 2016;26(4):505-22. DMAYHNI RU https://www.ncbi.nlm.nih.gov/pubmed/26924192 DMFXK03 DI DMFXK03 DMFXK03 DN Aminocyclopentenone compound 3 DMFXK03 MI TTRA6BO DMFXK03 MN Bromodomain-containing protein 4 (BRD4) DMFXK03 MT DTT DMFXK03 MA Inhibitor DMFXK03 RN BET inhibitors in cancer therapeutics: a patent review.Expert Opin Ther Pat. 2016;26(4):505-22. DMFXK03 RU https://www.ncbi.nlm.nih.gov/pubmed/26924192 DM745TN DI DM745TN DM745TN DN Aminocyclopentenone compound 4 DM745TN MI TTRA6BO DM745TN MN Bromodomain-containing protein 4 (BRD4) DM745TN MT DTT DM745TN MA Inhibitor DM745TN RN BET inhibitors in cancer therapeutics: a patent review.Expert Opin Ther Pat. 2016;26(4):505-22. DM745TN RU https://www.ncbi.nlm.nih.gov/pubmed/26924192 DMPW9ES DI DMPW9ES DMPW9ES DN Aminocyclopentenone compound 5 DMPW9ES MI TTRA6BO DMPW9ES MN Bromodomain-containing protein 4 (BRD4) DMPW9ES MT DTT DMPW9ES MA Inhibitor DMPW9ES RN BET inhibitors in cancer therapeutics: a patent review.Expert Opin Ther Pat. 2016;26(4):505-22. DMPW9ES RU https://www.ncbi.nlm.nih.gov/pubmed/26924192 DM0NJFZ DI DM0NJFZ DM0NJFZ DN Aminocyclopentenone compound 6 DM0NJFZ MI TTRA6BO DM0NJFZ MN Bromodomain-containing protein 4 (BRD4) DM0NJFZ MT DTT DM0NJFZ MA Inhibitor DM0NJFZ RN BET inhibitors in cancer therapeutics: a patent review.Expert Opin Ther Pat. 2016;26(4):505-22. DM0NJFZ RU https://www.ncbi.nlm.nih.gov/pubmed/26924192 DMDHGPN DI DMDHGPN DMDHGPN DN Aminooxazole carboxamide derivative 1 DMDHGPN MI TT6DM01 DMDHGPN MN Janus kinase 1 (JAK-1) DMDHGPN MT DTT DMDHGPN MA Inhibitor DMDHGPN RN Inhibitors of JAK-family kinases: an update on the patent literature 2013-2015, part 2.Expert Opin Ther Pat. 2017 Feb;27(2):145-161. DMDHGPN RU https://www.ncbi.nlm.nih.gov/pubmed/27774822 DMDHGPN DI DMDHGPN DMDHGPN DN Aminooxazole carboxamide derivative 1 DMDHGPN MI TTRMX3V DMDHGPN MN Janus kinase 2 (JAK-2) DMDHGPN MT DTT DMDHGPN MA Inhibitor DMDHGPN RN Inhibitors of JAK-family kinases: an update on the patent literature 2013-2015, part 2.Expert Opin Ther Pat. 2017 Feb;27(2):145-161. DMDHGPN RU https://www.ncbi.nlm.nih.gov/pubmed/27774822 DMDHGPN DI DMDHGPN DMDHGPN DN Aminooxazole carboxamide derivative 1 DMDHGPN MI TTT7PJU DMDHGPN MN Janus kinase 3 (JAK-3) DMDHGPN MT DTT DMDHGPN MA Inhibitor DMDHGPN RN Inhibitors of JAK-family kinases: an update on the patent literature 2013-2015, part 2.Expert Opin Ther Pat. 2017 Feb;27(2):145-161. DMDHGPN RU https://www.ncbi.nlm.nih.gov/pubmed/27774822 DMDHGPN DI DMDHGPN DMDHGPN DN Aminooxazole carboxamide derivative 1 DMDHGPN MI TTBYWP2 DMDHGPN MN TYK2 tyrosine kinase (TYK2) DMDHGPN MT DTT DMDHGPN MA Inhibitor DMDHGPN RN Inhibitors of JAK-family kinases: an update on the patent literature 2013-2015, part 2.Expert Opin Ther Pat. 2017 Feb;27(2):145-161. DMDHGPN RU https://www.ncbi.nlm.nih.gov/pubmed/27774822 DMFKTJL DI DMFKTJL DMFKTJL DN Aminopiperidine derivative 1 DMFKTJL MI TTDIGC1 DMFKTJL MN Dipeptidyl peptidase 4 (DPP-4) DMFKTJL MT DTT DMFKTJL MA Inhibitor DMFKTJL RN DPP-4 inhibitors: a patent review (2012 - 2014).Expert Opin Ther Pat. 2015 Feb;25(2):209-36. DMFKTJL RU https://www.ncbi.nlm.nih.gov/pubmed/25482888 DM4JDHO DI DM4JDHO DM4JDHO DN Aminopiperidine derivative 2 DM4JDHO MI TTDIGC1 DM4JDHO MN Dipeptidyl peptidase 4 (DPP-4) DM4JDHO MT DTT DM4JDHO MA Inhibitor DM4JDHO RN DPP-4 inhibitors: a patent review (2012 - 2014).Expert Opin Ther Pat. 2015 Feb;25(2):209-36. DM4JDHO RU https://www.ncbi.nlm.nih.gov/pubmed/25482888 DMYE1A7 DI DMYE1A7 DMYE1A7 DN Aminopyridine derivative 1 DMYE1A7 MI TTBYWP2 DMYE1A7 MN TYK2 tyrosine kinase (TYK2) DMYE1A7 MT DTT DMYE1A7 MA Inhibitor DMYE1A7 RN Inhibitors of JAK-family kinases: an update on the patent literature 2013-2015, part 2.Expert Opin Ther Pat. 2017 Feb;27(2):145-161. DMYE1A7 RU https://www.ncbi.nlm.nih.gov/pubmed/27774822 DMUGZNL DI DMUGZNL DMUGZNL DN Aminopyridine derivative 2 DMUGZNL MI TTK0FEA DMUGZNL MN Leucine-rich repeat kinase 2 (LRRK2) DMUGZNL MT DTT DMUGZNL MA Inhibitor DMUGZNL RN Leucine-rich repeat kinase 2 inhibitors: a patent review (2014-2016).Expert Opin Ther Pat. 2017 Jun;27(6):667-676. DMUGZNL RU https://www.ncbi.nlm.nih.gov/pubmed/28117607 DMSLJE8 DI DMSLJE8 DMSLJE8 DN Aminopyridine derivative 3 DMSLJE8 MI TTK0FEA DMSLJE8 MN Leucine-rich repeat kinase 2 (LRRK2) DMSLJE8 MT DTT DMSLJE8 MA Inhibitor DMSLJE8 RN Leucine-rich repeat kinase 2 inhibitors: a patent review (2014-2016).Expert Opin Ther Pat. 2017 Jun;27(6):667-676. DMSLJE8 RU https://www.ncbi.nlm.nih.gov/pubmed/28117607 DMSLJE8 DI DMSLJE8 DMSLJE8 DN Aminopyridine derivative 3 DMSLJE8 MI TT6AXLY DMSLJE8 MN Leucine-rich repeat kinase 2 G2019S mutant (LRRK2 G2019S) DMSLJE8 MT DTT DMSLJE8 MA Inhibitor DMSLJE8 RN Leucine-rich repeat kinase 2 inhibitors: a patent review (2014-2016).Expert Opin Ther Pat. 2017 Jun;27(6):667-676. DMSLJE8 RU https://www.ncbi.nlm.nih.gov/pubmed/28117607 DMK1UJV DI DMK1UJV DMK1UJV DN Aminopyrimidine derivative 1 DMK1UJV MI TTS7G69 DMK1UJV MN Fusion protein Bcr-Abl (Bcr-Abl) DMK1UJV MT DTT DMK1UJV MA Inhibitor DMK1UJV RN Bcr-Abl tyrosine kinase inhibitors: a patent review.Expert Opin Ther Pat. 2015 Apr;25(4):397-412. DMK1UJV RU https://www.ncbi.nlm.nih.gov/pubmed/25656651 DM2TF64 DI DM2TF64 DM2TF64 DN Aminopyrimidine derivative 10 DM2TF64 MI TTH5TC2 DM2TF64 MN NF-kappa-B-activating kinase (TBK1) DM2TF64 MT DTT DM2TF64 MA Inhibitor DM2TF64 RN TBK1 inhibitors: a review of patent literature (2011 - 2014).Expert Opin Ther Pat. 2015;25(12):1385-96. DM2TF64 RU https://www.ncbi.nlm.nih.gov/pubmed/26293650 DMKNITP DI DMKNITP DMKNITP DN Aminopyrimidine derivative 2 DMKNITP MI TTS7G69 DMKNITP MN Fusion protein Bcr-Abl (Bcr-Abl) DMKNITP MT DTT DMKNITP MA Inhibitor DMKNITP RN Bcr-Abl tyrosine kinase inhibitors: a patent review.Expert Opin Ther Pat. 2015 Apr;25(4):397-412. DMKNITP RU https://www.ncbi.nlm.nih.gov/pubmed/25656651 DMDP4GY DI DMDP4GY DMDP4GY DN Aminopyrimidine derivative 3 DMDP4GY MI TTS7G69 DMDP4GY MN Fusion protein Bcr-Abl (Bcr-Abl) DMDP4GY MT DTT DMDP4GY MA Inhibitor DMDP4GY RN Bcr-Abl tyrosine kinase inhibitors: a patent review.Expert Opin Ther Pat. 2015 Apr;25(4):397-412. DMDP4GY RU https://www.ncbi.nlm.nih.gov/pubmed/25656651 DMW039D DI DMW039D DMW039D DN Aminopyrimidine derivative 4 DMW039D MI TTS7G69 DMW039D MN Fusion protein Bcr-Abl (Bcr-Abl) DMW039D MT DTT DMW039D MA Inhibitor DMW039D RN Bcr-Abl tyrosine kinase inhibitors: a patent review.Expert Opin Ther Pat. 2015 Apr;25(4):397-412. DMW039D RU https://www.ncbi.nlm.nih.gov/pubmed/25656651 DM5OZPV DI DM5OZPV DM5OZPV DN Aminopyrimidine derivative 5 DM5OZPV MI TTBYWP2 DM5OZPV MN TYK2 tyrosine kinase (TYK2) DM5OZPV MT DTT DM5OZPV MA Inhibitor DM5OZPV RN Inhibitors of JAK-family kinases: an update on the patent literature 2013-2015, part 2.Expert Opin Ther Pat. 2017 Feb;27(2):145-161. DM5OZPV RU https://www.ncbi.nlm.nih.gov/pubmed/27774822 DMZF0DK DI DMZF0DK DMZF0DK DN Aminopyrimidine derivative 6 DMZF0DK MI TTH5TC2 DMZF0DK MN NF-kappa-B-activating kinase (TBK1) DMZF0DK MT DTT DMZF0DK MA Inhibitor DMZF0DK RN TBK1 inhibitors: a review of patent literature (2011 - 2014).Expert Opin Ther Pat. 2015;25(12):1385-96. DMZF0DK RU https://www.ncbi.nlm.nih.gov/pubmed/26293650 DMW98RI DI DMW98RI DMW98RI DN Aminopyrimidine derivative 7 DMW98RI MI TTH5TC2 DMW98RI MN NF-kappa-B-activating kinase (TBK1) DMW98RI MT DTT DMW98RI MA Inhibitor DMW98RI RN TBK1 inhibitors: a review of patent literature (2011 - 2014).Expert Opin Ther Pat. 2015;25(12):1385-96. DMW98RI RU https://www.ncbi.nlm.nih.gov/pubmed/26293650 DML83KW DI DML83KW DML83KW DN Aminopyrimidine derivative 8 DML83KW MI TTH5TC2 DML83KW MN NF-kappa-B-activating kinase (TBK1) DML83KW MT DTT DML83KW MA Inhibitor DML83KW RN TBK1 inhibitors: a review of patent literature (2011 - 2014).Expert Opin Ther Pat. 2015;25(12):1385-96. DML83KW RU https://www.ncbi.nlm.nih.gov/pubmed/26293650 DM5VRXW DI DM5VRXW DM5VRXW DN Aminopyrimidine derivative 9 DM5VRXW MI TTH5TC2 DM5VRXW MN NF-kappa-B-activating kinase (TBK1) DM5VRXW MT DTT DM5VRXW MA Inhibitor DM5VRXW RN TBK1 inhibitors: a review of patent literature (2011 - 2014).Expert Opin Ther Pat. 2015;25(12):1385-96. DM5VRXW RU https://www.ncbi.nlm.nih.gov/pubmed/26293650 DMW2LZ0 DI DMW2LZ0 DMW2LZ0 DN Aminotriazolopyridine derivative 1 DMW2LZ0 MI TTKAWRQ DMW2LZ0 MN JAK-STAT signaling pathway (JAK-STAT pathway) DMW2LZ0 MT DTT DMW2LZ0 MA Inhibitor DMW2LZ0 RN Inhibitors of JAK-family kinases: an update on the patent literature 2013-2015, part 1.Expert Opin Ther Pat. 2017 Feb;27(2):127-143. DMW2LZ0 RU https://www.ncbi.nlm.nih.gov/pubmed/27774824 DMW2LZ0 DI DMW2LZ0 DMW2LZ0 DN Aminotriazolopyridine derivative 1 DMW2LZ0 MI TT6DM01 DMW2LZ0 MN Janus kinase 1 (JAK-1) DMW2LZ0 MT DTT DMW2LZ0 MA Inhibitor DMW2LZ0 RN Inhibitors of JAK-family kinases: an update on the patent literature 2013-2015, part 1.Expert Opin Ther Pat. 2017 Feb;27(2):127-143. DMW2LZ0 RU https://www.ncbi.nlm.nih.gov/pubmed/27774824 DMW2LZ0 DI DMW2LZ0 DMW2LZ0 DN Aminotriazolopyridine derivative 1 DMW2LZ0 MI TTRMX3V DMW2LZ0 MN Janus kinase 2 (JAK-2) DMW2LZ0 MT DTT DMW2LZ0 MA Inhibitor DMW2LZ0 RN Inhibitors of JAK-family kinases: an update on the patent literature 2013-2015, part 1.Expert Opin Ther Pat. 2017 Feb;27(2):127-143. DMW2LZ0 RU https://www.ncbi.nlm.nih.gov/pubmed/27774824 DMW2LZ0 DI DMW2LZ0 DMW2LZ0 DN Aminotriazolopyridine derivative 1 DMW2LZ0 MI TTT7PJU DMW2LZ0 MN Janus kinase 3 (JAK-3) DMW2LZ0 MT DTT DMW2LZ0 MA Inhibitor DMW2LZ0 RN Inhibitors of JAK-family kinases: an update on the patent literature 2013-2015, part 1.Expert Opin Ther Pat. 2017 Feb;27(2):127-143. DMW2LZ0 RU https://www.ncbi.nlm.nih.gov/pubmed/27774824 DMW2LZ0 DI DMW2LZ0 DMW2LZ0 DN Aminotriazolopyridine derivative 1 DMW2LZ0 MI TTBYWP2 DMW2LZ0 MN TYK2 tyrosine kinase (TYK2) DMW2LZ0 MT DTT DMW2LZ0 MA Inhibitor DMW2LZ0 RN Inhibitors of JAK-family kinases: an update on the patent literature 2013-2015, part 1.Expert Opin Ther Pat. 2017 Feb;27(2):127-143. DMW2LZ0 RU https://www.ncbi.nlm.nih.gov/pubmed/27774824 DMW2LZ0 DI DMW2LZ0 DMW2LZ0 DN Aminotriazolopyridine derivative 1 DMW2LZ0 MI TTJSQEF DMW2LZ0 MN Tyrosine-protein kinase (PTK) DMW2LZ0 MT DTT DMW2LZ0 MA Inhibitor DMW2LZ0 RN Inhibitors of JAK-family kinases: an update on the patent literature 2013-2015, part 1.Expert Opin Ther Pat. 2017 Feb;27(2):127-143. DMW2LZ0 RU https://www.ncbi.nlm.nih.gov/pubmed/27774824 DM2V31C DI DM2V31C DM2V31C DN Ampicidin analog 1 DM2V31C MI TTBH0VX DM2V31C MN Histone deacetylase (HDAC) DM2V31C MT DTT DM2V31C MA Inhibitor DM2V31C RN Antiplasmodial drug targets: a patent review (2000 - 2013).Expert Opin Ther Pat. 2016;26(1):107-30. DM2V31C RU https://www.ncbi.nlm.nih.gov/pubmed/26566576 DMZH8S9 DI DMZH8S9 DMZH8S9 DN Ampicidin analog 2 DMZH8S9 MI TTBH0VX DMZH8S9 MN Histone deacetylase (HDAC) DMZH8S9 MT DTT DMZH8S9 MA Inhibitor DMZH8S9 RN Antiplasmodial drug targets: a patent review (2000 - 2013).Expert Opin Ther Pat. 2016;26(1):107-30. DMZH8S9 RU https://www.ncbi.nlm.nih.gov/pubmed/26566576 DMDSUGF DI DMDSUGF DMDSUGF DN Aniline derivative 1 DMDSUGF MI TT7HF4W DMDSUGF MN Cyclin-dependent kinase 2 (CDK2) DMDSUGF MT DTT DMDSUGF MA Inhibitor DMDSUGF RN Cyclin-dependent kinase inhibitors for cancer therapy: a patent review (2009 - 2014).Expert Opin Ther Pat. 2015;25(9):953-70. DMDSUGF RU https://www.ncbi.nlm.nih.gov/pubmed/26161698 DMDSUGF DI DMDSUGF DMDSUGF DN Aniline derivative 1 DMDSUGF MI TTBH0VX DMDSUGF MN Histone deacetylase (HDAC) DMDSUGF MT DTT DMDSUGF MA Inhibitor DMDSUGF RN Cyclin-dependent kinase inhibitors for cancer therapy: a patent review (2009 - 2014).Expert Opin Ther Pat. 2015;25(9):953-70. DMDSUGF RU https://www.ncbi.nlm.nih.gov/pubmed/26161698 DMY5J23 DI DMY5J23 DMY5J23 DN Antibodie derivative 1 DMY5J23 MI TTOHSBA DMY5J23 MN Vascular endothelial growth factor A (VEGFA) DMY5J23 MT DTT DMY5J23 MA Blocker DMY5J23 RN VEGFR-2 inhibitors and the therapeutic applications thereof: a patent review (2012-2016).Expert Opin Ther Pat. 2017 Sep;27(9):987-1004. DMY5J23 RU https://www.ncbi.nlm.nih.gov/pubmed/28621580 DMGP5AR DI DMGP5AR DMGP5AR DN Antibodie derivative 10 DMGP5AR MI TTUTJGQ DMGP5AR MN Vascular endothelial growth factor receptor 2 (KDR) DMGP5AR MT DTT DMGP5AR RN VEGFR-2 inhibitors and the therapeutic applications thereof: a patent review (2012-2016).Expert Opin Ther Pat. 2017 Sep;27(9):987-1004. DMGP5AR RU https://www.ncbi.nlm.nih.gov/pubmed/28621580 DMPG3Y8 DI DMPG3Y8 DMPG3Y8 DN Antibodie derivative 11 DMPG3Y8 MI TTOHSBA DMPG3Y8 MN Vascular endothelial growth factor A (VEGFA) DMPG3Y8 MT DTT DMPG3Y8 RN VEGFR-2 inhibitors and the therapeutic applications thereof: a patent review (2012-2016).Expert Opin Ther Pat. 2017 Sep;27(9):987-1004. DMPG3Y8 RU https://www.ncbi.nlm.nih.gov/pubmed/28621580 DMU7YC2 DI DMU7YC2 DMU7YC2 DN Antibodie derivative 2 DMU7YC2 MI TTOHSBA DMU7YC2 MN Vascular endothelial growth factor A (VEGFA) DMU7YC2 MT DTT DMU7YC2 MA Binder DMU7YC2 RN VEGFR-2 inhibitors and the therapeutic applications thereof: a patent review (2012-2016).Expert Opin Ther Pat. 2017 Sep;27(9):987-1004. DMU7YC2 RU https://www.ncbi.nlm.nih.gov/pubmed/28621580 DMNPBRG DI DMNPBRG DMNPBRG DN Antibodie derivative 3 DMNPBRG MI TTOHSBA DMNPBRG MN Vascular endothelial growth factor A (VEGFA) DMNPBRG MT DTT DMNPBRG RN VEGFR-2 inhibitors and the therapeutic applications thereof: a patent review (2012-2016).Expert Opin Ther Pat. 2017 Sep;27(9):987-1004. DMNPBRG RU https://www.ncbi.nlm.nih.gov/pubmed/28621580 DM2WMGO DI DM2WMGO DM2WMGO DN Antibodie derivative 4 DM2WMGO MI TTOHSBA DM2WMGO MN Vascular endothelial growth factor A (VEGFA) DM2WMGO MT DTT DM2WMGO MA Inhibitor DM2WMGO RN VEGFR-2 inhibitors and the therapeutic applications thereof: a patent review (2012-2016).Expert Opin Ther Pat. 2017 Sep;27(9):987-1004. DM2WMGO RU https://www.ncbi.nlm.nih.gov/pubmed/28621580 DMRTZE4 DI DMRTZE4 DMRTZE4 DN Antibodie derivative 5 DMRTZE4 MI TTOUZN5 DMRTZE4 MN Gremlin-1 (Gremlin-1) DMRTZE4 MT DTT DMRTZE4 MA Inhibitor DMRTZE4 RN VEGFR-2 inhibitors and the therapeutic applications thereof: a patent review (2012-2016).Expert Opin Ther Pat. 2017 Sep;27(9):987-1004. DMRTZE4 RU https://www.ncbi.nlm.nih.gov/pubmed/28621580 DMUG6YT DI DMUG6YT DMUG6YT DN Antibodie derivative 6 DMUG6YT MI TTUTJGQ DMUG6YT MN Vascular endothelial growth factor receptor 2 (KDR) DMUG6YT MT DTT DMUG6YT MA Binder DMUG6YT RN VEGFR-2 inhibitors and the therapeutic applications thereof: a patent review (2012-2016).Expert Opin Ther Pat. 2017 Sep;27(9):987-1004. DMUG6YT RU https://www.ncbi.nlm.nih.gov/pubmed/28621580 DMJN37O DI DMJN37O DMJN37O DN Antibodie derivative 7 DMJN37O MI TTOHSBA DMJN37O MN Vascular endothelial growth factor A (VEGFA) DMJN37O MT DTT DMJN37O MA Binder DMJN37O RN VEGFR-2 inhibitors and the therapeutic applications thereof: a patent review (2012-2016).Expert Opin Ther Pat. 2017 Sep;27(9):987-1004. DMJN37O RU https://www.ncbi.nlm.nih.gov/pubmed/28621580 DM0CEJM DI DM0CEJM DM0CEJM DN Antibodie derivative 8 DM0CEJM MI TTOHSBA DM0CEJM MN Vascular endothelial growth factor A (VEGFA) DM0CEJM MT DTT DM0CEJM MA Disrupter DM0CEJM RN VEGFR-2 inhibitors and the therapeutic applications thereof: a patent review (2012-2016).Expert Opin Ther Pat. 2017 Sep;27(9):987-1004. DM0CEJM RU https://www.ncbi.nlm.nih.gov/pubmed/28621580 DMDRJ31 DI DMDRJ31 DMDRJ31 DN Antibodie derivative 9 DMDRJ31 MI TTOHSBA DMDRJ31 MN Vascular endothelial growth factor A (VEGFA) DMDRJ31 MT DTT DMDRJ31 MA Stablizer DMDRJ31 RN VEGFR-2 inhibitors and the therapeutic applications thereof: a patent review (2012-2016).Expert Opin Ther Pat. 2017 Sep;27(9):987-1004. DMDRJ31 RU https://www.ncbi.nlm.nih.gov/pubmed/28621580 DMLQ8N1 DI DMLQ8N1 DMLQ8N1 DN AphanamgrandiolA DMLQ8N1 MI TT3WG5C DMLQ8N1 MN Monoamine oxidase type A (MAO-A) DMLQ8N1 MT DTT DMLQ8N1 MA Inhibitor DMLQ8N1 RN Novel monoamine oxidase inhibitors: a patent review (2012 - 2014).Expert Opin Ther Pat. 2015 Jan;25(1):91-110. DMLQ8N1 RU https://www.ncbi.nlm.nih.gov/pubmed/25399762 DM7AXSM DI DM7AXSM DM7AXSM DN Apogossypolone DM7AXSM MI TTGT9C7 DM7AXSM MN Bcl-2-related protein A1 (BCL2A1) DM7AXSM MT DTT DM7AXSM MA Inhibitor DM7AXSM RN Apogossypolone derivatives as anticancer agents. US8937193. DM7AXSM RU http://www.freepatentsonline.com/US8937193.html DMUPN01 DI DMUPN01 DMUPN01 DN AR-A014418 DMUPN01 MI TTRZQE3 DMUPN01 MN Glycogen synthase kinase-3 alpha (GSK-3A) DMUPN01 MT DTT DMUPN01 RN Glycogen synthase kinase 3 (GSK-3) inhibitors: a patent update (2014-2015).Expert Opin Ther Pat. 2017 Jun;27(6):657-666. DMUPN01 RU https://www.ncbi.nlm.nih.gov/pubmed/27828716 DMUPN01 DI DMUPN01 DMUPN01 DN AR-A014418 DMUPN01 MI TTRSMW9 DMUPN01 MN Glycogen synthase kinase-3 beta (GSK-3B) DMUPN01 MT DTT DMUPN01 MA Inhibitor DMUPN01 RN Fragment and knowledge-based design of selective GSK-3beta inhibitors using virtual screening models. Eur J Med Chem. 2009 Jun;44(6):2361-71. DMUPN01 RU https://pubmed.ncbi.nlm.nih.gov/18929433 DMGR6X1 DI DMGR6X1 DMGR6X1 DN Aromatic acetylene derivative 1 DMGR6X1 MI TT23XQV DMGR6X1 MN PD-1-PD-L1 interaction (PD-1/PD-L1 PPI) DMGR6X1 MT DTT DMGR6X1 MA Inhibitor DMGR6X1 RN A patent review on PD-1/PD-L1 antagonists: small molecules, peptides, and macrocycles (2015-2018).Expert Opin Ther Pat. 2018 Sep;28(9):665-678. DMGR6X1 RU https://www.ncbi.nlm.nih.gov/pubmed/30107136 DMXW0PV DI DMXW0PV DMXW0PV DN Aromatic and heteroaryl compound 1 DMXW0PV MI TTUX68I DMXW0PV MN Hypoxia-inducible factor 1 (HIF-1) DMXW0PV MT DTT DMXW0PV MA Inhibitor DMXW0PV RN Hypoxia-inducible factor (HIF) inhibitors: a patent survey (2011-2015).Expert Opin Ther Pat. 2016;26(3):309-22. DMXW0PV RU https://www.ncbi.nlm.nih.gov/pubmed/26882240 DMVLQ2P DI DMVLQ2P DMVLQ2P DN Aromatic bicyclic compound 1 DMVLQ2P MI TTRMX3V DMVLQ2P MN Janus kinase 2 (JAK-2) DMVLQ2P MT DTT DMVLQ2P MA Inhibitor DMVLQ2P RN A STAT inhibitor patent review: progress since 2011.Expert Opin Ther Pat. 2015;25(12):1397-421. DMVLQ2P RU https://www.ncbi.nlm.nih.gov/pubmed/26394986 DMVLQ2P DI DMVLQ2P DMVLQ2P DN Aromatic bicyclic compound 1 DMVLQ2P MI TT6PKBN DMVLQ2P MN Proto-oncogene c-Src (SRC) DMVLQ2P MT DTT DMVLQ2P MA Inhibitor DMVLQ2P RN A STAT inhibitor patent review: progress since 2011.Expert Opin Ther Pat. 2015;25(12):1397-421. DMVLQ2P RU https://www.ncbi.nlm.nih.gov/pubmed/26394986 DMKFV67 DI DMKFV67 DMKFV67 DN Aromatic bicyclic compound 2 DMKFV67 MI TTRMX3V DMKFV67 MN Janus kinase 2 (JAK-2) DMKFV67 MT DTT DMKFV67 MA Inhibitor DMKFV67 RN A STAT inhibitor patent review: progress since 2011.Expert Opin Ther Pat. 2015;25(12):1397-421. DMKFV67 RU https://www.ncbi.nlm.nih.gov/pubmed/26394986 DMKFV67 DI DMKFV67 DMKFV67 DN Aromatic bicyclic compound 2 DMKFV67 MI TT6PKBN DMKFV67 MN Proto-oncogene c-Src (SRC) DMKFV67 MT DTT DMKFV67 MA Inhibitor DMKFV67 RN A STAT inhibitor patent review: progress since 2011.Expert Opin Ther Pat. 2015;25(12):1397-421. DMKFV67 RU https://www.ncbi.nlm.nih.gov/pubmed/26394986 DMRXN94 DI DMRXN94 DMRXN94 DN Aromatic bicyclic compound 3 DMRXN94 MI TTRMX3V DMRXN94 MN Janus kinase 2 (JAK-2) DMRXN94 MT DTT DMRXN94 MA Inhibitor DMRXN94 RN A STAT inhibitor patent review: progress since 2011.Expert Opin Ther Pat. 2015;25(12):1397-421. DMRXN94 RU https://www.ncbi.nlm.nih.gov/pubmed/26394986 DMRXN94 DI DMRXN94 DMRXN94 DN Aromatic bicyclic compound 3 DMRXN94 MI TT6PKBN DMRXN94 MN Proto-oncogene c-Src (SRC) DMRXN94 MT DTT DMRXN94 MA Inhibitor DMRXN94 RN A STAT inhibitor patent review: progress since 2011.Expert Opin Ther Pat. 2015;25(12):1397-421. DMRXN94 RU https://www.ncbi.nlm.nih.gov/pubmed/26394986 DM3E75P DI DM3E75P DM3E75P DN Aromatic bicyclic compound 4 DM3E75P MI TTRMX3V DM3E75P MN Janus kinase 2 (JAK-2) DM3E75P MT DTT DM3E75P MA Inhibitor DM3E75P RN A STAT inhibitor patent review: progress since 2011.Expert Opin Ther Pat. 2015;25(12):1397-421. DM3E75P RU https://www.ncbi.nlm.nih.gov/pubmed/26394986 DM3E75P DI DM3E75P DM3E75P DN Aromatic bicyclic compound 4 DM3E75P MI TT6PKBN DM3E75P MN Proto-oncogene c-Src (SRC) DM3E75P MT DTT DM3E75P MA Inhibitor DM3E75P RN A STAT inhibitor patent review: progress since 2011.Expert Opin Ther Pat. 2015;25(12):1397-421. DM3E75P RU https://www.ncbi.nlm.nih.gov/pubmed/26394986 DMALF06 DI DMALF06 DMALF06 DN Aromatic bicyclic compound 5 DMALF06 MI TTRMX3V DMALF06 MN Janus kinase 2 (JAK-2) DMALF06 MT DTT DMALF06 MA Inhibitor DMALF06 RN A STAT inhibitor patent review: progress since 2011.Expert Opin Ther Pat. 2015;25(12):1397-421. DMALF06 RU https://www.ncbi.nlm.nih.gov/pubmed/26394986 DMALF06 DI DMALF06 DMALF06 DN Aromatic bicyclic compound 5 DMALF06 MI TT6PKBN DMALF06 MN Proto-oncogene c-Src (SRC) DMALF06 MT DTT DMALF06 MA Inhibitor DMALF06 RN A STAT inhibitor patent review: progress since 2011.Expert Opin Ther Pat. 2015;25(12):1397-421. DMALF06 RU https://www.ncbi.nlm.nih.gov/pubmed/26394986 DM8L3KM DI DM8L3KM DM8L3KM DN Aromatic bicyclic compound 6 DM8L3KM MI TTRMX3V DM8L3KM MN Janus kinase 2 (JAK-2) DM8L3KM MT DTT DM8L3KM MA Inhibitor DM8L3KM RN A STAT inhibitor patent review: progress since 2011.Expert Opin Ther Pat. 2015;25(12):1397-421. DM8L3KM RU https://www.ncbi.nlm.nih.gov/pubmed/26394986 DM8L3KM DI DM8L3KM DM8L3KM DN Aromatic bicyclic compound 6 DM8L3KM MI TT6PKBN DM8L3KM MN Proto-oncogene c-Src (SRC) DM8L3KM MT DTT DM8L3KM MA Inhibitor DM8L3KM RN A STAT inhibitor patent review: progress since 2011.Expert Opin Ther Pat. 2015;25(12):1397-421. DM8L3KM RU https://www.ncbi.nlm.nih.gov/pubmed/26394986 DMSRKON DI DMSRKON DMSRKON DN Aromatic ethylene derivative 1 DMSRKON MI TT23XQV DMSRKON MN PD-1-PD-L1 interaction (PD-1/PD-L1 PPI) DMSRKON MT DTT DMSRKON MA Inhibitor DMSRKON RN A patent review on PD-1/PD-L1 antagonists: small molecules, peptides, and macrocycles (2015-2018).Expert Opin Ther Pat. 2018 Sep;28(9):665-678. DMSRKON RU https://www.ncbi.nlm.nih.gov/pubmed/30107136 DMJ8X7A DI DMJ8X7A DMJ8X7A DN Aromatic hydrazine carboxyimidoamide derivative 1 DMJ8X7A MI TTULVH8 DMJ8X7A MN Tyrosinase (TYR) DMJ8X7A MT DTT DMJ8X7A MA Inhibitor DMJ8X7A RN Tyrosinase inhibitors: a patent review (2011-2015).Expert Opin Ther Pat. 2016;26(3):347-62. DMJ8X7A RU https://www.ncbi.nlm.nih.gov/pubmed/26815044 DMYH4D1 DI DMYH4D1 DMYH4D1 DN Aromatic hydrazine carboxyimidoamide derivative 2 DMYH4D1 MI TTULVH8 DMYH4D1 MN Tyrosinase (TYR) DMYH4D1 MT DTT DMYH4D1 MA Inhibitor DMYH4D1 RN Tyrosinase inhibitors: a patent review (2011-2015).Expert Opin Ther Pat. 2016;26(3):347-62. DMYH4D1 RU https://www.ncbi.nlm.nih.gov/pubmed/26815044 DML63B7 DI DML63B7 DML63B7 DN Aromatic hydrazine carboxyimidoamide derivative 3 DML63B7 MI TTULVH8 DML63B7 MN Tyrosinase (TYR) DML63B7 MT DTT DML63B7 MA Inhibitor DML63B7 RN Tyrosinase inhibitors: a patent review (2011-2015).Expert Opin Ther Pat. 2016;26(3):347-62. DML63B7 RU https://www.ncbi.nlm.nih.gov/pubmed/26815044 DMKE5PB DI DMKE5PB DMKE5PB DN Aromatic hydrazine carboxyimidoamide derivative 4 DMKE5PB MI TTULVH8 DMKE5PB MN Tyrosinase (TYR) DMKE5PB MT DTT DMKE5PB MA Inhibitor DMKE5PB RN Tyrosinase inhibitors: a patent review (2011-2015).Expert Opin Ther Pat. 2016;26(3):347-62. DMKE5PB RU https://www.ncbi.nlm.nih.gov/pubmed/26815044 DM4AM1E DI DM4AM1E DM4AM1E DN Aromatic hydrazine carboxyimidoamide derivative 5 DM4AM1E MI TTULVH8 DM4AM1E MN Tyrosinase (TYR) DM4AM1E MT DTT DM4AM1E MA Inhibitor DM4AM1E RN Tyrosinase inhibitors: a patent review (2011-2015).Expert Opin Ther Pat. 2016;26(3):347-62. DM4AM1E RU https://www.ncbi.nlm.nih.gov/pubmed/26815044 DM8HDQT DI DM8HDQT DM8HDQT DN Aromatic hydrazine carboxyimidoamide derivative 6 DM8HDQT MI TTULVH8 DM8HDQT MN Tyrosinase (TYR) DM8HDQT MT DTT DM8HDQT MA Inhibitor DM8HDQT RN Tyrosinase inhibitors: a patent review (2011-2015).Expert Opin Ther Pat. 2016;26(3):347-62. DM8HDQT RU https://www.ncbi.nlm.nih.gov/pubmed/26815044 DMJX6DV DI DMJX6DV DMJX6DV DN Aromatic ring compound 1 DMJX6DV MI TT9O6WS DMJX6DV MN Glucagon receptor (GCGR) DMJX6DV MT DTT DMJX6DV MA Antagonist DMJX6DV RN Small molecule glucagon receptor antagonists: a patent review (2011 - 2014).Expert Opin Ther Pat. 2015 Jul;25(7):819-30. DMJX6DV RU https://www.ncbi.nlm.nih.gov/pubmed/25828189 DMMAS3G DI DMMAS3G DMMAS3G DN Aromatic ring compound 2 DMMAS3G MI TT9O6WS DMMAS3G MN Glucagon receptor (GCGR) DMMAS3G MT DTT DMMAS3G MA Antagonist DMMAS3G RN Small molecule glucagon receptor antagonists: a patent review (2011 - 2014).Expert Opin Ther Pat. 2015 Jul;25(7):819-30. DMMAS3G RU https://www.ncbi.nlm.nih.gov/pubmed/25828189 DM43APD DI DM43APD DM43APD DN Aromatic ring compound 3 DM43APD MI TT9O6WS DM43APD MN Glucagon receptor (GCGR) DM43APD MT DTT DM43APD MA Antagonist DM43APD RN Small molecule glucagon receptor antagonists: a patent review (2011 - 2014).Expert Opin Ther Pat. 2015 Jul;25(7):819-30. DM43APD RU https://www.ncbi.nlm.nih.gov/pubmed/25828189 DMXGLST DI DMXGLST DMXGLST DN Aromatic ring compound 4 DMXGLST MI TT9O6WS DMXGLST MN Glucagon receptor (GCGR) DMXGLST MT DTT DMXGLST MA Antagonist DMXGLST RN Small molecule glucagon receptor antagonists: a patent review (2011 - 2014).Expert Opin Ther Pat. 2015 Jul;25(7):819-30. DMXGLST RU https://www.ncbi.nlm.nih.gov/pubmed/25828189 DMSDRNQ DI DMSDRNQ DMSDRNQ DN Aryl 1,2-diamine derivative 1 DMSDRNQ MI TTZJYKH DMSDRNQ MN Indoleamine 2,3-dioxygenase 1 (IDO1) DMSDRNQ MT DTT DMSDRNQ MA Inhibitor DMSDRNQ RN A patent review of IDO1 inhibitors for cancer.Expert Opin Ther Pat. 2018 Apr;28(4):317-330. DMSDRNQ RU https://www.ncbi.nlm.nih.gov/pubmed/29473428 DM417XY DI DM417XY DM417XY DN Aryl alkanolamine derivative 1 DM417XY MI TT5TPI6 DM417XY MN Opioid receptor sigma 1 (OPRS1) DM417XY MT DTT DM417XY MA Antagonist DM417XY RN Are sigma modulators an effective opportunity for cancer treatment A patent overview (1996-2016).Expert Opin Ther Pat. 2017 May;27(5):565-578. DM417XY RU https://www.ncbi.nlm.nih.gov/pubmed/28051882 DMUP0WH DI DMUP0WH DMUP0WH DN Aryl alkanolamine derivative 2 DMUP0WH MI TT5TPI6 DMUP0WH MN Opioid receptor sigma 1 (OPRS1) DMUP0WH MT DTT DMUP0WH MA Antagonist DMUP0WH RN Are sigma modulators an effective opportunity for cancer treatment A patent overview (1996-2016).Expert Opin Ther Pat. 2017 May;27(5):565-578. DMUP0WH RU https://www.ncbi.nlm.nih.gov/pubmed/28051882 DMA9B0V DI DMA9B0V DMA9B0V DN Aryl azepine derivative 1 DMA9B0V MI TT9NXW4 DMA9B0V MN Sigma intracellular receptor 2 (TMEM97) DMA9B0V MT DTT DMA9B0V MA Ligand DMA9B0V RN The sigma-2 (-2) receptor: a review of recent patent applications: 2013-2018.Expert Opin Ther Pat. 2018 Sep;28(9):655-663. DMA9B0V RU https://www.ncbi.nlm.nih.gov/pubmed/30185082 DMI4XBC DI DMI4XBC DMI4XBC DN Aryl azepine derivative 2 DMI4XBC MI TT9NXW4 DMI4XBC MN Sigma intracellular receptor 2 (TMEM97) DMI4XBC MT DTT DMI4XBC MA Ligand DMI4XBC RN The sigma-2 (-2) receptor: a review of recent patent applications: 2013-2018.Expert Opin Ther Pat. 2018 Sep;28(9):655-663. DMI4XBC RU https://www.ncbi.nlm.nih.gov/pubmed/30185082 DMGZHRT DI DMGZHRT DMGZHRT DN Aryl carbamate analog 1 DMGZHRT MI TTUX68I DMGZHRT MN Hypoxia-inducible factor 1 (HIF-1) DMGZHRT MT DTT DMGZHRT MA Inhibitor DMGZHRT RN Hypoxia-inducible factor (HIF) inhibitors: a patent survey (2011-2015).Expert Opin Ther Pat. 2016;26(3):309-22. DMGZHRT RU https://www.ncbi.nlm.nih.gov/pubmed/26882240 DMTZRCW DI DMTZRCW DMTZRCW DN Aryl carboxamide derivative 1 DMTZRCW MI TTAXZ0K DMTZRCW MN Voltage-gated sodium channel alpha Nav1.3 (SCN3A) DMTZRCW MT DTT DMTZRCW MA Inhibitor DMTZRCW RN Sodium channel blockers: a patent review (2010 - 2014).Expert Opin Ther Pat. 2015 Mar;25(3):279-90. DMTZRCW RU https://www.ncbi.nlm.nih.gov/pubmed/25539043 DMTZRCW DI DMTZRCW DMTZRCW DN Aryl carboxamide derivative 1 DMTZRCW MI TTZOVE0 DMTZRCW MN Voltage-gated sodium channel alpha Nav1.5 (SCN5A) DMTZRCW MT DTT DMTZRCW MA Inhibitor DMTZRCW RN Sodium channel blockers: a patent review (2010 - 2014).Expert Opin Ther Pat. 2015 Mar;25(3):279-90. DMTZRCW RU https://www.ncbi.nlm.nih.gov/pubmed/25539043 DMTZRCW DI DMTZRCW DMTZRCW DN Aryl carboxamide derivative 1 DMTZRCW MI TT4G2JS DMTZRCW MN Voltage-gated sodium channel alpha Nav1.7 (SCN9A) DMTZRCW MT DTT DMTZRCW MA Inhibitor DMTZRCW RN Sodium channel blockers: a patent review (2010 - 2014).Expert Opin Ther Pat. 2015 Mar;25(3):279-90. DMTZRCW RU https://www.ncbi.nlm.nih.gov/pubmed/25539043 DM146TA DI DM146TA DM146TA DN Aryl carboxamide derivative 2 DM146TA MI TTAXZ0K DM146TA MN Voltage-gated sodium channel alpha Nav1.3 (SCN3A) DM146TA MT DTT DM146TA MA Inhibitor DM146TA RN Sodium channel blockers: a patent review (2010 - 2014).Expert Opin Ther Pat. 2015 Mar;25(3):279-90. DM146TA RU https://www.ncbi.nlm.nih.gov/pubmed/25539043 DM146TA DI DM146TA DM146TA DN Aryl carboxamide derivative 2 DM146TA MI TTZOVE0 DM146TA MN Voltage-gated sodium channel alpha Nav1.5 (SCN5A) DM146TA MT DTT DM146TA MA Inhibitor DM146TA RN Sodium channel blockers: a patent review (2010 - 2014).Expert Opin Ther Pat. 2015 Mar;25(3):279-90. DM146TA RU https://www.ncbi.nlm.nih.gov/pubmed/25539043 DM146TA DI DM146TA DM146TA DN Aryl carboxamide derivative 2 DM146TA MI TT4G2JS DM146TA MN Voltage-gated sodium channel alpha Nav1.7 (SCN9A) DM146TA MT DTT DM146TA MA Inhibitor DM146TA RN Sodium channel blockers: a patent review (2010 - 2014).Expert Opin Ther Pat. 2015 Mar;25(3):279-90. DM146TA RU https://www.ncbi.nlm.nih.gov/pubmed/25539043 DM6FQ8L DI DM6FQ8L DM6FQ8L DN Aryl carboxamide derivative 3 DM6FQ8L MI TTZOVE0 DM6FQ8L MN Voltage-gated sodium channel alpha Nav1.5 (SCN5A) DM6FQ8L MT DTT DM6FQ8L MA Inhibitor DM6FQ8L RN Sodium channel blockers: a patent review (2010 - 2014).Expert Opin Ther Pat. 2015 Mar;25(3):279-90. DM6FQ8L RU https://www.ncbi.nlm.nih.gov/pubmed/25539043 DMNBW8P DI DMNBW8P DMNBW8P DN Aryl carboxamide derivative 4 DMNBW8P MI TT4G2JS DMNBW8P MN Voltage-gated sodium channel alpha Nav1.7 (SCN9A) DMNBW8P MT DTT DMNBW8P MA Inhibitor DMNBW8P RN Sodium channel blockers: a patent review (2010 - 2014).Expert Opin Ther Pat. 2015 Mar;25(3):279-90. DMNBW8P RU https://www.ncbi.nlm.nih.gov/pubmed/25539043 DMZECH7 DI DMZECH7 DMZECH7 DN Aryl cyclopropylamine derivative 3 DMZECH7 MI TTNR0UQ DMZECH7 MN Lysine-specific histone demethylase 1 (LSD) DMZECH7 MT DTT DMZECH7 MA Inhibitor DMZECH7 RN LSD1 inhibitors: a patent review (2010-2015).Expert Opin Ther Pat. 2016 May;26(5):565-80. DMZECH7 RU https://www.ncbi.nlm.nih.gov/pubmed/27019002 DM0C1ZO DI DM0C1ZO DM0C1ZO DN Aryl cyclopropylamine derivative 4 DM0C1ZO MI TTNR0UQ DM0C1ZO MN Lysine-specific histone demethylase 1 (LSD) DM0C1ZO MT DTT DM0C1ZO MA Inhibitor DM0C1ZO RN LSD1 inhibitors: a patent review (2010-2015).Expert Opin Ther Pat. 2016 May;26(5):565-80. DM0C1ZO RU https://www.ncbi.nlm.nih.gov/pubmed/27019002 DM6CK7J DI DM6CK7J DM6CK7J DN Aryl cyclopropylamine derivative 5 DM6CK7J MI TTNR0UQ DM6CK7J MN Lysine-specific histone demethylase 1 (LSD) DM6CK7J MT DTT DM6CK7J MA Inhibitor DM6CK7J RN LSD1 inhibitors: a patent review (2010-2015).Expert Opin Ther Pat. 2016 May;26(5):565-80. DM6CK7J RU https://www.ncbi.nlm.nih.gov/pubmed/27019002 DM1TV6F DI DM1TV6F DM1TV6F DN Aryl mannoside derivative 1 DM1TV6F MI TTTCRU2 DM1TV6F MN Bacterial Fimbrin D-mannose adhesin (Bact FimH) DM1TV6F MT DTT DM1TV6F MA Antagonist DM1TV6F RN Mannose-derived FimH antagonists: a promising anti-virulence therapeutic strategy for urinary tract infections and Crohn's disease.Expert Opin Ther Pat. 2016;26(2):175-97. DM1TV6F RU https://www.ncbi.nlm.nih.gov/pubmed/26651364 DM251GL DI DM251GL DM251GL DN Aryl mannoside derivative 10 DM251GL MI TTTCRU2 DM251GL MN Bacterial Fimbrin D-mannose adhesin (Bact FimH) DM251GL MT DTT DM251GL MA Antagonist DM251GL RN Mannose-derived FimH antagonists: a promising anti-virulence therapeutic strategy for urinary tract infections and Crohn's disease.Expert Opin Ther Pat. 2016;26(2):175-97. DM251GL RU https://www.ncbi.nlm.nih.gov/pubmed/26651364 DMRVIPL DI DMRVIPL DMRVIPL DN Aryl mannoside derivative 11 DMRVIPL MI TTTCRU2 DMRVIPL MN Bacterial Fimbrin D-mannose adhesin (Bact FimH) DMRVIPL MT DTT DMRVIPL MA Antagonist DMRVIPL RN Mannose-derived FimH antagonists: a promising anti-virulence therapeutic strategy for urinary tract infections and Crohn's disease.Expert Opin Ther Pat. 2016;26(2):175-97. DMRVIPL RU https://www.ncbi.nlm.nih.gov/pubmed/26651364 DMOG8XT DI DMOG8XT DMOG8XT DN Aryl mannoside derivative 12 DMOG8XT MI TTTCRU2 DMOG8XT MN Bacterial Fimbrin D-mannose adhesin (Bact FimH) DMOG8XT MT DTT DMOG8XT MA Antagonist DMOG8XT RN Mannose-derived FimH antagonists: a promising anti-virulence therapeutic strategy for urinary tract infections and Crohn's disease.Expert Opin Ther Pat. 2016;26(2):175-97. DMOG8XT RU https://www.ncbi.nlm.nih.gov/pubmed/26651364 DM2W7JE DI DM2W7JE DM2W7JE DN Aryl mannoside derivative 13 DM2W7JE MI TTTCRU2 DM2W7JE MN Bacterial Fimbrin D-mannose adhesin (Bact FimH) DM2W7JE MT DTT DM2W7JE MA Antagonist DM2W7JE RN Mannose-derived FimH antagonists: a promising anti-virulence therapeutic strategy for urinary tract infections and Crohn's disease.Expert Opin Ther Pat. 2016;26(2):175-97. DM2W7JE RU https://www.ncbi.nlm.nih.gov/pubmed/26651364 DMR648Z DI DMR648Z DMR648Z DN Aryl mannoside derivative 14 DMR648Z MI TTTCRU2 DMR648Z MN Bacterial Fimbrin D-mannose adhesin (Bact FimH) DMR648Z MT DTT DMR648Z MA Antagonist DMR648Z RN Mannose-derived FimH antagonists: a promising anti-virulence therapeutic strategy for urinary tract infections and Crohn's disease.Expert Opin Ther Pat. 2016;26(2):175-97. DMR648Z RU https://www.ncbi.nlm.nih.gov/pubmed/26651364 DMQS8CF DI DMQS8CF DMQS8CF DN Aryl mannoside derivative 15 DMQS8CF MI TTTCRU2 DMQS8CF MN Bacterial Fimbrin D-mannose adhesin (Bact FimH) DMQS8CF MT DTT DMQS8CF MA Antagonist DMQS8CF RN Mannose-derived FimH antagonists: a promising anti-virulence therapeutic strategy for urinary tract infections and Crohn's disease.Expert Opin Ther Pat. 2016;26(2):175-97. DMQS8CF RU https://www.ncbi.nlm.nih.gov/pubmed/26651364 DMP6QEC DI DMP6QEC DMP6QEC DN Aryl mannoside derivative 16 DMP6QEC MI TTTCRU2 DMP6QEC MN Bacterial Fimbrin D-mannose adhesin (Bact FimH) DMP6QEC MT DTT DMP6QEC MA Antagonist DMP6QEC RN Mannose-derived FimH antagonists: a promising anti-virulence therapeutic strategy for urinary tract infections and Crohn's disease.Expert Opin Ther Pat. 2016;26(2):175-97. DMP6QEC RU https://www.ncbi.nlm.nih.gov/pubmed/26651364 DM0FSPQ DI DM0FSPQ DM0FSPQ DN Aryl mannoside derivative 17 DM0FSPQ MI TTTCRU2 DM0FSPQ MN Bacterial Fimbrin D-mannose adhesin (Bact FimH) DM0FSPQ MT DTT DM0FSPQ MA Antagonist DM0FSPQ RN Mannose-derived FimH antagonists: a promising anti-virulence therapeutic strategy for urinary tract infections and Crohn's disease.Expert Opin Ther Pat. 2016;26(2):175-97. DM0FSPQ RU https://www.ncbi.nlm.nih.gov/pubmed/26651364 DM0YUBR DI DM0YUBR DM0YUBR DN Aryl mannoside derivative 18 DM0YUBR MI TTTCRU2 DM0YUBR MN Bacterial Fimbrin D-mannose adhesin (Bact FimH) DM0YUBR MT DTT DM0YUBR MA Antagonist DM0YUBR RN Mannose-derived FimH antagonists: a promising anti-virulence therapeutic strategy for urinary tract infections and Crohn's disease.Expert Opin Ther Pat. 2016;26(2):175-97. DM0YUBR RU https://www.ncbi.nlm.nih.gov/pubmed/26651364 DM6K29H DI DM6K29H DM6K29H DN Aryl mannoside derivative 19 DM6K29H MI TTTCRU2 DM6K29H MN Bacterial Fimbrin D-mannose adhesin (Bact FimH) DM6K29H MT DTT DM6K29H MA Antagonist DM6K29H RN Mannose-derived FimH antagonists: a promising anti-virulence therapeutic strategy for urinary tract infections and Crohn's disease.Expert Opin Ther Pat. 2016;26(2):175-97. DM6K29H RU https://www.ncbi.nlm.nih.gov/pubmed/26651364 DM4S2U5 DI DM4S2U5 DM4S2U5 DN Aryl mannoside derivative 2 DM4S2U5 MI TTTCRU2 DM4S2U5 MN Bacterial Fimbrin D-mannose adhesin (Bact FimH) DM4S2U5 MT DTT DM4S2U5 MA Antagonist DM4S2U5 RN Mannose-derived FimH antagonists: a promising anti-virulence therapeutic strategy for urinary tract infections and Crohn's disease.Expert Opin Ther Pat. 2016;26(2):175-97. DM4S2U5 RU https://www.ncbi.nlm.nih.gov/pubmed/26651364 DMZ2RV3 DI DMZ2RV3 DMZ2RV3 DN Aryl mannoside derivative 20 DMZ2RV3 MI TTTCRU2 DMZ2RV3 MN Bacterial Fimbrin D-mannose adhesin (Bact FimH) DMZ2RV3 MT DTT DMZ2RV3 MA Antagonist DMZ2RV3 RN Mannose-derived FimH antagonists: a promising anti-virulence therapeutic strategy for urinary tract infections and Crohn's disease.Expert Opin Ther Pat. 2016;26(2):175-97. DMZ2RV3 RU https://www.ncbi.nlm.nih.gov/pubmed/26651364 DMJBY68 DI DMJBY68 DMJBY68 DN Aryl mannoside derivative 21 DMJBY68 MI TTTCRU2 DMJBY68 MN Bacterial Fimbrin D-mannose adhesin (Bact FimH) DMJBY68 MT DTT DMJBY68 MA Antagonist DMJBY68 RN Mannose-derived FimH antagonists: a promising anti-virulence therapeutic strategy for urinary tract infections and Crohn's disease.Expert Opin Ther Pat. 2016;26(2):175-97. DMJBY68 RU https://www.ncbi.nlm.nih.gov/pubmed/26651364 DMJFDNB DI DMJFDNB DMJFDNB DN Aryl mannoside derivative 22 DMJFDNB MI TTTCRU2 DMJFDNB MN Bacterial Fimbrin D-mannose adhesin (Bact FimH) DMJFDNB MT DTT DMJFDNB MA Antagonist DMJFDNB RN Mannose-derived FimH antagonists: a promising anti-virulence therapeutic strategy for urinary tract infections and Crohn's disease.Expert Opin Ther Pat. 2016;26(2):175-97. DMJFDNB RU https://www.ncbi.nlm.nih.gov/pubmed/26651364 DMWUNRV DI DMWUNRV DMWUNRV DN Aryl mannoside derivative 23 DMWUNRV MI TTTCRU2 DMWUNRV MN Bacterial Fimbrin D-mannose adhesin (Bact FimH) DMWUNRV MT DTT DMWUNRV MA Antagonist DMWUNRV RN Mannose-derived FimH antagonists: a promising anti-virulence therapeutic strategy for urinary tract infections and Crohn's disease.Expert Opin Ther Pat. 2016;26(2):175-97. DMWUNRV RU https://www.ncbi.nlm.nih.gov/pubmed/26651364 DMF5XU8 DI DMF5XU8 DMF5XU8 DN Aryl mannoside derivative 3 DMF5XU8 MI TTTCRU2 DMF5XU8 MN Bacterial Fimbrin D-mannose adhesin (Bact FimH) DMF5XU8 MT DTT DMF5XU8 MA Antagonist DMF5XU8 RN Mannose-derived FimH antagonists: a promising anti-virulence therapeutic strategy for urinary tract infections and Crohn's disease.Expert Opin Ther Pat. 2016;26(2):175-97. DMF5XU8 RU https://www.ncbi.nlm.nih.gov/pubmed/26651364 DMO19Y6 DI DMO19Y6 DMO19Y6 DN Aryl mannoside derivative 4 DMO19Y6 MI TTTCRU2 DMO19Y6 MN Bacterial Fimbrin D-mannose adhesin (Bact FimH) DMO19Y6 MT DTT DMO19Y6 MA Antagonist DMO19Y6 RN Mannose-derived FimH antagonists: a promising anti-virulence therapeutic strategy for urinary tract infections and Crohn's disease.Expert Opin Ther Pat. 2016;26(2):175-97. DMO19Y6 RU https://www.ncbi.nlm.nih.gov/pubmed/26651364 DMMC31R DI DMMC31R DMMC31R DN Aryl mannoside derivative 5 DMMC31R MI TTTCRU2 DMMC31R MN Bacterial Fimbrin D-mannose adhesin (Bact FimH) DMMC31R MT DTT DMMC31R MA Antagonist DMMC31R RN Mannose-derived FimH antagonists: a promising anti-virulence therapeutic strategy for urinary tract infections and Crohn's disease.Expert Opin Ther Pat. 2016;26(2):175-97. DMMC31R RU https://www.ncbi.nlm.nih.gov/pubmed/26651364 DM5MIEC DI DM5MIEC DM5MIEC DN Aryl mannoside derivative 6 DM5MIEC MI TTTCRU2 DM5MIEC MN Bacterial Fimbrin D-mannose adhesin (Bact FimH) DM5MIEC MT DTT DM5MIEC MA Antagonist DM5MIEC RN Mannose-derived FimH antagonists: a promising anti-virulence therapeutic strategy for urinary tract infections and Crohn's disease.Expert Opin Ther Pat. 2016;26(2):175-97. DM5MIEC RU https://www.ncbi.nlm.nih.gov/pubmed/26651364 DM9YS40 DI DM9YS40 DM9YS40 DN Aryl mannoside derivative 7 DM9YS40 MI TTTCRU2 DM9YS40 MN Bacterial Fimbrin D-mannose adhesin (Bact FimH) DM9YS40 MT DTT DM9YS40 MA Antagonist DM9YS40 RN Mannose-derived FimH antagonists: a promising anti-virulence therapeutic strategy for urinary tract infections and Crohn's disease.Expert Opin Ther Pat. 2016;26(2):175-97. DM9YS40 RU https://www.ncbi.nlm.nih.gov/pubmed/26651364 DMK6PFQ DI DMK6PFQ DMK6PFQ DN Aryl mannoside derivative 8 DMK6PFQ MI TTTCRU2 DMK6PFQ MN Bacterial Fimbrin D-mannose adhesin (Bact FimH) DMK6PFQ MT DTT DMK6PFQ MA Antagonist DMK6PFQ RN Mannose-derived FimH antagonists: a promising anti-virulence therapeutic strategy for urinary tract infections and Crohn's disease.Expert Opin Ther Pat. 2016;26(2):175-97. DMK6PFQ RU https://www.ncbi.nlm.nih.gov/pubmed/26651364 DMNSK7U DI DMNSK7U DMNSK7U DN Aryl mannoside derivative 9 DMNSK7U MI TTTCRU2 DMNSK7U MN Bacterial Fimbrin D-mannose adhesin (Bact FimH) DMNSK7U MT DTT DMNSK7U MA Antagonist DMNSK7U RN Mannose-derived FimH antagonists: a promising anti-virulence therapeutic strategy for urinary tract infections and Crohn's disease.Expert Opin Ther Pat. 2016;26(2):175-97. DMNSK7U RU https://www.ncbi.nlm.nih.gov/pubmed/26651364 DMBWH3O DI DMBWH3O DMBWH3O DN Aryl methoxyacrylate derivative 1 DMBWH3O MI TTUX68I DMBWH3O MN Hypoxia-inducible factor 1 (HIF-1) DMBWH3O MT DTT DMBWH3O MA Inhibitor DMBWH3O RN Hypoxia-inducible factor (HIF) inhibitors: a patent survey (2011-2015).Expert Opin Ther Pat. 2016;26(3):309-22. DMBWH3O RU https://www.ncbi.nlm.nih.gov/pubmed/26882240 DMNC0RX DI DMNC0RX DMNC0RX DN Aryl methoxyacrylate derivative 2 DMNC0RX MI TTUX68I DMNC0RX MN Hypoxia-inducible factor 1 (HIF-1) DMNC0RX MT DTT DMNC0RX MA Inhibitor DMNC0RX RN Hypoxia-inducible factor (HIF) inhibitors: a patent survey (2011-2015).Expert Opin Ther Pat. 2016;26(3):309-22. DMNC0RX RU https://www.ncbi.nlm.nih.gov/pubmed/26882240 DML1IXV DI DML1IXV DML1IXV DN Aryl oxyanilide derivative 1 DML1IXV MI TTPTXIN DML1IXV MN Translocator protein (TSPO) DML1IXV MT DTT DML1IXV MA Ligand DML1IXV RN Translocator protein (TSPO) ligands for the diagnosis or treatment of neurodegenerative diseases: a patent review (2010-2015; part 1).Expert Opin Ther Pat. 2016 Nov;26(11):1325-1351. DML1IXV RU https://www.ncbi.nlm.nih.gov/pubmed/27607364 DM47V3I DI DM47V3I DM47V3I DN Aryl oxyanilide derivative 2 DM47V3I MI TTPTXIN DM47V3I MN Translocator protein (TSPO) DM47V3I MT DTT DM47V3I MA Ligand DM47V3I RN Translocator protein (TSPO) ligands for the diagnosis or treatment of neurodegenerative diseases: a patent review (2010-2015; part 1).Expert Opin Ther Pat. 2016 Nov;26(11):1325-1351. DM47V3I RU https://www.ncbi.nlm.nih.gov/pubmed/27607364 DMSGO7D DI DMSGO7D DMSGO7D DN Aryl oxyanilide derivative 3 DMSGO7D MI TTPTXIN DMSGO7D MN Translocator protein (TSPO) DMSGO7D MT DTT DMSGO7D MA Ligand DMSGO7D RN Translocator protein (TSPO) ligands for the diagnosis or treatment of neurodegenerative diseases: a patent review (2010-2015; part 1).Expert Opin Ther Pat. 2016 Nov;26(11):1325-1351. DMSGO7D RU https://www.ncbi.nlm.nih.gov/pubmed/27607364 DM9DJGU DI DM9DJGU DM9DJGU DN Aryl piperazine derivative 1 DM9DJGU MI TTSQIFT DM9DJGU MN 5-HT 1A receptor (HTR1A) DM9DJGU MT DTT DM9DJGU MA Ligand DM9DJGU RN 5-HT1A receptor ligands and their therapeutic applications: review of new patents.Expert Opin Ther Pat. 2018 Sep;28(9):679-689. DM9DJGU RU https://www.ncbi.nlm.nih.gov/pubmed/30124346 DM9DJGU DI DM9DJGU DM9DJGU DN Aryl piperazine derivative 1 DM9DJGU MI TTJQOD7 DM9DJGU MN 5-HT 2A receptor (HTR2A) DM9DJGU MT DTT DM9DJGU MA Ligand DM9DJGU RN 5-HT1A receptor ligands and their therapeutic applications: review of new patents.Expert Opin Ther Pat. 2018 Sep;28(9):679-689. DM9DJGU RU https://www.ncbi.nlm.nih.gov/pubmed/30124346 DM9DJGU DI DM9DJGU DM9DJGU DN Aryl piperazine derivative 1 DM9DJGU MI TTEX248 DM9DJGU MN Dopamine D2 receptor (D2R) DM9DJGU MT DTT DM9DJGU MA Ligand DM9DJGU RN 5-HT1A receptor ligands and their therapeutic applications: review of new patents.Expert Opin Ther Pat. 2018 Sep;28(9):679-689. DM9DJGU RU https://www.ncbi.nlm.nih.gov/pubmed/30124346 DM9DJGU DI DM9DJGU DM9DJGU DN Aryl piperazine derivative 1 DM9DJGU MI TT4C8EA DM9DJGU MN Dopamine D3 receptor (D3R) DM9DJGU MT DTT DM9DJGU MA Ligand DM9DJGU RN 5-HT1A receptor ligands and their therapeutic applications: review of new patents.Expert Opin Ther Pat. 2018 Sep;28(9):679-689. DM9DJGU RU https://www.ncbi.nlm.nih.gov/pubmed/30124346 DM5EGBY DI DM5EGBY DM5EGBY DN Aryl piperazine derivative 10 DM5EGBY MI TTWJBZ5 DM5EGBY MN 5-HT 2C receptor (HTR2C) DM5EGBY MT DTT DM5EGBY MA Agonist DM5EGBY RN Novel serotonin receptor 2 (5-HT2R) agonists and antagonists: a patent review (2004-2014).Expert Opin Ther Pat. 2016;26(1):89-106. DM5EGBY RU https://www.ncbi.nlm.nih.gov/pubmed/26609882 DMY8NEL DI DMY8NEL DMY8NEL DN Aryl piperazine derivative 14 DMY8NEL MI TTWT5K7 DMY8NEL MN 5-HT 1 receptor (5HT1R) DMY8NEL MT DTT DMY8NEL MA Agonist DMY8NEL RN 5-HT1A receptor ligands and their therapeutic applications: review of new patents.Expert Opin Ther Pat. 2018 Sep;28(9):679-689. DMY8NEL RU https://www.ncbi.nlm.nih.gov/pubmed/30124346 DMY8NEL DI DMY8NEL DMY8NEL DN Aryl piperazine derivative 14 DMY8NEL MI TTSQIFT DMY8NEL MN 5-HT 1A receptor (HTR1A) DMY8NEL MT DTT DMY8NEL MA Agonist DMY8NEL RN 5-HT1A receptor ligands and their therapeutic applications: review of new patents.Expert Opin Ther Pat. 2018 Sep;28(9):679-689. DMY8NEL RU https://www.ncbi.nlm.nih.gov/pubmed/30124346 DMRK4IE DI DMRK4IE DMRK4IE DN Aryl piperazine derivative 15 DMRK4IE MI TTWT5K7 DMRK4IE MN 5-HT 1 receptor (5HT1R) DMRK4IE MT DTT DMRK4IE MA Agonist DMRK4IE RN 5-HT1A receptor ligands and their therapeutic applications: review of new patents.Expert Opin Ther Pat. 2018 Sep;28(9):679-689. DMRK4IE RU https://www.ncbi.nlm.nih.gov/pubmed/30124346 DMRK4IE DI DMRK4IE DMRK4IE DN Aryl piperazine derivative 15 DMRK4IE MI TTSQIFT DMRK4IE MN 5-HT 1A receptor (HTR1A) DMRK4IE MT DTT DMRK4IE MA Agonist DMRK4IE RN 5-HT1A receptor ligands and their therapeutic applications: review of new patents.Expert Opin Ther Pat. 2018 Sep;28(9):679-689. DMRK4IE RU https://www.ncbi.nlm.nih.gov/pubmed/30124346 DM63XHT DI DM63XHT DM63XHT DN Aryl piperazine derivative 16 DM63XHT MI TTWT5K7 DM63XHT MN 5-HT 1 receptor (5HT1R) DM63XHT MT DTT DM63XHT MA Agonist DM63XHT RN 5-HT1A receptor ligands and their therapeutic applications: review of new patents.Expert Opin Ther Pat. 2018 Sep;28(9):679-689. DM63XHT RU https://www.ncbi.nlm.nih.gov/pubmed/30124346 DM63XHT DI DM63XHT DM63XHT DN Aryl piperazine derivative 16 DM63XHT MI TTSQIFT DM63XHT MN 5-HT 1A receptor (HTR1A) DM63XHT MT DTT DM63XHT MA Agonist DM63XHT RN 5-HT1A receptor ligands and their therapeutic applications: review of new patents.Expert Opin Ther Pat. 2018 Sep;28(9):679-689. DM63XHT RU https://www.ncbi.nlm.nih.gov/pubmed/30124346 DMZ3DS5 DI DMZ3DS5 DMZ3DS5 DN Aryl piperazine derivative 6 DMZ3DS5 MI TTSQIFT DMZ3DS5 MN 5-HT 1A receptor (HTR1A) DMZ3DS5 MT DTT DMZ3DS5 MA Ligand DMZ3DS5 RN 5-HT1A receptor ligands and their therapeutic applications: review of new patents.Expert Opin Ther Pat. 2018 Sep;28(9):679-689. DMZ3DS5 RU https://www.ncbi.nlm.nih.gov/pubmed/30124346 DMZ3DS5 DI DMZ3DS5 DMZ3DS5 DN Aryl piperazine derivative 6 DMZ3DS5 MI TTJQOD7 DMZ3DS5 MN 5-HT 2A receptor (HTR2A) DMZ3DS5 MT DTT DMZ3DS5 MA Ligand DMZ3DS5 RN 5-HT1A receptor ligands and their therapeutic applications: review of new patents.Expert Opin Ther Pat. 2018 Sep;28(9):679-689. DMZ3DS5 RU https://www.ncbi.nlm.nih.gov/pubmed/30124346 DMZ3DS5 DI DMZ3DS5 DMZ3DS5 DN Aryl piperazine derivative 6 DMZ3DS5 MI TTEX248 DMZ3DS5 MN Dopamine D2 receptor (D2R) DMZ3DS5 MT DTT DMZ3DS5 MA Ligand DMZ3DS5 RN 5-HT1A receptor ligands and their therapeutic applications: review of new patents.Expert Opin Ther Pat. 2018 Sep;28(9):679-689. DMZ3DS5 RU https://www.ncbi.nlm.nih.gov/pubmed/30124346 DMZ3DS5 DI DMZ3DS5 DMZ3DS5 DN Aryl piperazine derivative 6 DMZ3DS5 MI TT4C8EA DMZ3DS5 MN Dopamine D3 receptor (D3R) DMZ3DS5 MT DTT DMZ3DS5 MA Ligand DMZ3DS5 RN 5-HT1A receptor ligands and their therapeutic applications: review of new patents.Expert Opin Ther Pat. 2018 Sep;28(9):679-689. DMZ3DS5 RU https://www.ncbi.nlm.nih.gov/pubmed/30124346 DM7BRIT DI DM7BRIT DM7BRIT DN Aryl piperazine derivative 8 DM7BRIT MI TTWJBZ5 DM7BRIT MN 5-HT 2C receptor (HTR2C) DM7BRIT MT DTT DM7BRIT MA Agonist DM7BRIT RN Novel serotonin receptor 2 (5-HT2R) agonists and antagonists: a patent review (2004-2014).Expert Opin Ther Pat. 2016;26(1):89-106. DM7BRIT RU https://www.ncbi.nlm.nih.gov/pubmed/26609882 DMLKNWF DI DMLKNWF DMLKNWF DN Aryl piperazine derivative 9 DMLKNWF MI TTJQOD7 DMLKNWF MN 5-HT 2A receptor (HTR2A) DMLKNWF MT DTT DMLKNWF MA Agonist DMLKNWF RN Novel serotonin receptor 2 (5-HT2R) agonists and antagonists: a patent review (2004-2014).Expert Opin Ther Pat. 2016;26(1):89-106. DMLKNWF RU https://www.ncbi.nlm.nih.gov/pubmed/26609882 DMLKNWF DI DMLKNWF DMLKNWF DN Aryl piperazine derivative 9 DMLKNWF MI TTWJBZ5 DMLKNWF MN 5-HT 2C receptor (HTR2C) DMLKNWF MT DTT DMLKNWF MA Agonist DMLKNWF RN Novel serotonin receptor 2 (5-HT2R) agonists and antagonists: a patent review (2004-2014).Expert Opin Ther Pat. 2016;26(1):89-106. DMLKNWF RU https://www.ncbi.nlm.nih.gov/pubmed/26609882 DM3CVWU DI DM3CVWU DM3CVWU DN Aryl pyrimidine derivative 1 DM3CVWU MI TT1LVF2 DM3CVWU MN Cyclin-dependent kinase 9 (CDK9) DM3CVWU MT DTT DM3CVWU MA Inhibitor DM3CVWU RN Cyclin-dependent kinase inhibitors for cancer therapy: a patent review (2009 - 2014).Expert Opin Ther Pat. 2015;25(9):953-70. DM3CVWU RU https://www.ncbi.nlm.nih.gov/pubmed/26161698 DMU9Y4B DI DMU9Y4B DMU9Y4B DN Aryl pyrimidine derivative 2 DMU9Y4B MI TTIY56R DMU9Y4B MN Kynurenine 3-hydroxylase (KMO) DMU9Y4B MT DTT DMU9Y4B MA Inhibitor DMU9Y4B RN Inhibitors of the kynurenine pathway as neurotherapeutics: a patent review (2012-2015).Expert Opin Ther Pat. 2016 Jul;26(7):815-32. DMU9Y4B RU https://www.ncbi.nlm.nih.gov/pubmed/27172114 DMXND26 DI DMXND26 DMXND26 DN Aryl pyrimidine derivative 3 DMXND26 MI TTIY56R DMXND26 MN Kynurenine 3-hydroxylase (KMO) DMXND26 MT DTT DMXND26 MA Inhibitor DMXND26 RN Inhibitors of the kynurenine pathway as neurotherapeutics: a patent review (2012-2015).Expert Opin Ther Pat. 2016 Jul;26(7):815-32. DMXND26 RU https://www.ncbi.nlm.nih.gov/pubmed/27172114 DMWSAL5 DI DMWSAL5 DMWSAL5 DN Aryl pyrimidine derivative 4 DMWSAL5 MI TTIY56R DMWSAL5 MN Kynurenine 3-hydroxylase (KMO) DMWSAL5 MT DTT DMWSAL5 MA Inhibitor DMWSAL5 RN Inhibitors of the kynurenine pathway as neurotherapeutics: a patent review (2012-2015).Expert Opin Ther Pat. 2016 Jul;26(7):815-32. DMWSAL5 RU https://www.ncbi.nlm.nih.gov/pubmed/27172114 DMEP9O8 DI DMEP9O8 DMEP9O8 DN Aryl pyrimidine derivative 5 DMEP9O8 MI TTIY56R DMEP9O8 MN Kynurenine 3-hydroxylase (KMO) DMEP9O8 MT DTT DMEP9O8 MA Inhibitor DMEP9O8 RN Inhibitors of the kynurenine pathway as neurotherapeutics: a patent review (2012-2015).Expert Opin Ther Pat. 2016 Jul;26(7):815-32. DMEP9O8 RU https://www.ncbi.nlm.nih.gov/pubmed/27172114 DMMF9U6 DI DMMF9U6 DMMF9U6 DN Aryl pyrimidine derivative 6 DMMF9U6 MI TTIY56R DMMF9U6 MN Kynurenine 3-hydroxylase (KMO) DMMF9U6 MT DTT DMMF9U6 MA Inhibitor DMMF9U6 RN Inhibitors of the kynurenine pathway as neurotherapeutics: a patent review (2012-2015).Expert Opin Ther Pat. 2016 Jul;26(7):815-32. DMMF9U6 RU https://www.ncbi.nlm.nih.gov/pubmed/27172114 DM8FAW3 DI DM8FAW3 DM8FAW3 DN Aryl pyrimidine derivative 7 DM8FAW3 MI TTIY56R DM8FAW3 MN Kynurenine 3-hydroxylase (KMO) DM8FAW3 MT DTT DM8FAW3 MA Inhibitor DM8FAW3 RN Inhibitors of the kynurenine pathway as neurotherapeutics: a patent review (2012-2015).Expert Opin Ther Pat. 2016 Jul;26(7):815-32. DM8FAW3 RU https://www.ncbi.nlm.nih.gov/pubmed/27172114 DM7OA9E DI DM7OA9E DM7OA9E DN Aryl pyrimidine derivative 8 DM7OA9E MI TTIY56R DM7OA9E MN Kynurenine 3-hydroxylase (KMO) DM7OA9E MT DTT DM7OA9E MA Inhibitor DM7OA9E RN Inhibitors of the kynurenine pathway as neurotherapeutics: a patent review (2012-2015).Expert Opin Ther Pat. 2016 Jul;26(7):815-32. DM7OA9E RU https://www.ncbi.nlm.nih.gov/pubmed/27172114 DMBEYD1 DI DMBEYD1 DMBEYD1 DN Aryl pyrimidine derivative 9 DMBEYD1 MI TTIY56R DMBEYD1 MN Kynurenine 3-hydroxylase (KMO) DMBEYD1 MT DTT DMBEYD1 MA Inhibitor DMBEYD1 RN Inhibitors of the kynurenine pathway as neurotherapeutics: a patent review (2012-2015).Expert Opin Ther Pat. 2016 Jul;26(7):815-32. DMBEYD1 RU https://www.ncbi.nlm.nih.gov/pubmed/27172114 DMW7HKS DI DMW7HKS DMW7HKS DN Aryl sulphoxide imine derivative 1 DMW7HKS MI TTZJYKH DMW7HKS MN Indoleamine 2,3-dioxygenase 1 (IDO1) DMW7HKS MT DTT DMW7HKS MA Inhibitor DMW7HKS RN A patent review of IDO1 inhibitors for cancer.Expert Opin Ther Pat. 2018 Apr;28(4):317-330. DMW7HKS RU https://www.ncbi.nlm.nih.gov/pubmed/29473428 DM0B9SP DI DM0B9SP DM0B9SP DN Aryl urea derivative 1 DM0B9SP MI TTDP1UC DM0B9SP MN Fatty acid amide hydrolase (FAAH) DM0B9SP MT DTT DM0B9SP MA Inhibitor DM0B9SP RN Fatty acid amide hydrolase inhibitors: a patent review (2009-2014).Expert Opin Ther Pat. 2015;25(11):1247-66. DM0B9SP RU https://www.ncbi.nlm.nih.gov/pubmed/26413912 DMQWJ12 DI DMQWJ12 DMQWJ12 DN Aryl urea derivative 2 DMQWJ12 MI TTDP1UC DMQWJ12 MN Fatty acid amide hydrolase (FAAH) DMQWJ12 MT DTT DMQWJ12 MA Inhibitor DMQWJ12 RN Fatty acid amide hydrolase inhibitors: a patent review (2009-2014).Expert Opin Ther Pat. 2015;25(11):1247-66. DMQWJ12 RU https://www.ncbi.nlm.nih.gov/pubmed/26413912 DM1G7KI DI DM1G7KI DM1G7KI DN Aryl urea derivative 3 DM1G7KI MI TTDP1UC DM1G7KI MN Fatty acid amide hydrolase (FAAH) DM1G7KI MT DTT DM1G7KI MA Inhibitor DM1G7KI RN Fatty acid amide hydrolase inhibitors: a patent review (2009-2014).Expert Opin Ther Pat. 2015;25(11):1247-66. DM1G7KI RU https://www.ncbi.nlm.nih.gov/pubmed/26413912 DM0HOJW DI DM0HOJW DM0HOJW DN Aryl urea derivative 4 DM0HOJW MI TTDP1UC DM0HOJW MN Fatty acid amide hydrolase (FAAH) DM0HOJW MT DTT DM0HOJW MA Inhibitor DM0HOJW RN Fatty acid amide hydrolase inhibitors: a patent review (2009-2014).Expert Opin Ther Pat. 2015;25(11):1247-66. DM0HOJW RU https://www.ncbi.nlm.nih.gov/pubmed/26413912 DM54V1R DI DM54V1R DM54V1R DN Aryl urea derivative 5 DM54V1R MI TTDP1UC DM54V1R MN Fatty acid amide hydrolase (FAAH) DM54V1R MT DTT DM54V1R MA Inhibitor DM54V1R RN Fatty acid amide hydrolase inhibitors: a patent review (2009-2014).Expert Opin Ther Pat. 2015;25(11):1247-66. DM54V1R RU https://www.ncbi.nlm.nih.gov/pubmed/26413912 DMGM72Q DI DMGM72Q DMGM72Q DN A-substituted phenylpropionic acid derivative 1 DMGM72Q MI TTZMAO3 DMGM72Q MN Peroxisome proliferator-activated receptor gamma (PPAR-gamma) DMGM72Q MT DTT DMGM72Q MA Agonist DMGM72Q RN PPAR ligands and their therapeutic applications: a patent review (2008 - 2014).Expert Opin Ther Pat. 2015 Feb;25(2):175-91. DMGM72Q RU https://www.ncbi.nlm.nih.gov/pubmed/25416646 DMH5FEO DI DMH5FEO DMH5FEO DN A-substituted phenylpropionic acid derivative 2 DMH5FEO MI TTZMAO3 DMH5FEO MN Peroxisome proliferator-activated receptor gamma (PPAR-gamma) DMH5FEO MT DTT DMH5FEO MA Agonist DMH5FEO RN PPAR ligands and their therapeutic applications: a patent review (2008 - 2014).Expert Opin Ther Pat. 2015 Feb;25(2):175-91. DMH5FEO RU https://www.ncbi.nlm.nih.gov/pubmed/25416646 DMRG1NL DI DMRG1NL DMRG1NL DN Atorvastatin lactole derivative 1 DMRG1NL MI TTPADOQ DMRG1NL MN HMG-CoA reductase (HMGCR) DMRG1NL MT DTT DMRG1NL MA Inhibitor DMRG1NL RN HMG-CoA Reductase inhibitors: an updated review of patents of novel compounds and formulations (2011-2015).Expert Opin Ther Pat. 2016 Nov;26(11):1257-1272. DMRG1NL RU https://www.ncbi.nlm.nih.gov/pubmed/27537201 DMVD5TA DI DMVD5TA DMVD5TA DN Azachalcone derivative 1 DMVD5TA MI TT2F4OL DMVD5TA MN Tissue transglutaminase (TG2) DMVD5TA MT DTT DMVD5TA MA Inhibitor DMVD5TA RN Transglutaminase inhibitors: a patent review.Expert Opin Ther Pat. 2016;26(1):49-63. DMVD5TA RU https://www.ncbi.nlm.nih.gov/pubmed/26560530 DMJWH4B DI DMJWH4B DMJWH4B DN Azaindazole amide derivative 1 DMJWH4B MI TTKN7QR DMJWH4B MN BDNF/NT-3 growth factors receptor (TrkB) DMJWH4B MT DTT DMJWH4B MA Inhibitor DMJWH4B RN Tropomyosin receptor kinase inhibitors: an updated patent review for 2010-2016 - Part II.Expert Opin Ther Pat. 2017 Jul;27(7):831-849. DMJWH4B RU https://www.ncbi.nlm.nih.gov/pubmed/28270021 DMJWH4B DI DMJWH4B DMJWH4B DN Azaindazole amide derivative 1 DMJWH4B MI TTXABCW DMJWH4B MN NT-3 growth factor receptor (TrkC) DMJWH4B MT DTT DMJWH4B MA Inhibitor DMJWH4B RN Tropomyosin receptor kinase inhibitors: an updated patent review for 2010-2016 - Part II.Expert Opin Ther Pat. 2017 Jul;27(7):831-849. DMJWH4B RU https://www.ncbi.nlm.nih.gov/pubmed/28270021 DMJWH4B DI DMJWH4B DMJWH4B DN Azaindazole amide derivative 1 DMJWH4B MI TTTDVOJ DMJWH4B MN Tropomyosin-related kinase A (TrkA) DMJWH4B MT DTT DMJWH4B MA Inhibitor DMJWH4B RN Tropomyosin receptor kinase inhibitors: an updated patent review for 2010-2016 - Part II.Expert Opin Ther Pat. 2017 Jul;27(7):831-849. DMJWH4B RU https://www.ncbi.nlm.nih.gov/pubmed/28270021 DM3S0LI DI DM3S0LI DM3S0LI DN Azaindazole derivative 1 DM3S0LI MI TTK0FEA DM3S0LI MN Leucine-rich repeat kinase 2 (LRRK2) DM3S0LI MT DTT DM3S0LI MA Inhibitor DM3S0LI RN Leucine-rich repeat kinase 2 inhibitors: a patent review (2014-2016).Expert Opin Ther Pat. 2017 Jun;27(6):667-676. DM3S0LI RU https://www.ncbi.nlm.nih.gov/pubmed/28117607 DMEYS3V DI DMEYS3V DMEYS3V DN Azaindazole derivative 2 DMEYS3V MI TTK0FEA DMEYS3V MN Leucine-rich repeat kinase 2 (LRRK2) DMEYS3V MT DTT DMEYS3V MA Inhibitor DMEYS3V RN Leucine-rich repeat kinase 2 inhibitors: a patent review (2014-2016).Expert Opin Ther Pat. 2017 Jun;27(6):667-676. DMEYS3V RU https://www.ncbi.nlm.nih.gov/pubmed/28117607 DMOV9XA DI DMOV9XA DMOV9XA DN Azaindazole derivative 3 DMOV9XA MI TTK0FEA DMOV9XA MN Leucine-rich repeat kinase 2 (LRRK2) DMOV9XA MT DTT DMOV9XA MA Inhibitor DMOV9XA RN Leucine-rich repeat kinase 2 inhibitors: a patent review (2014-2016).Expert Opin Ther Pat. 2017 Jun;27(6):667-676. DMOV9XA RU https://www.ncbi.nlm.nih.gov/pubmed/28117607 DMX3MNT DI DMX3MNT DMX3MNT DN Azaindazole derivative 4 DMX3MNT MI TTK0FEA DMX3MNT MN Leucine-rich repeat kinase 2 (LRRK2) DMX3MNT MT DTT DMX3MNT MA Inhibitor DMX3MNT RN Leucine-rich repeat kinase 2 inhibitors: a patent review (2014-2016).Expert Opin Ther Pat. 2017 Jun;27(6):667-676. DMX3MNT RU https://www.ncbi.nlm.nih.gov/pubmed/28117607 DMSMXK3 DI DMSMXK3 DMSMXK3 DN Azaindole derivative 1 DMSMXK3 MI TT3PJMV DMSMXK3 MN Tyrosine-protein kinase ABL1 (ABL) DMSMXK3 MT DTT DMSMXK3 MA Inhibitor DMSMXK3 RN Bcr-Abl tyrosine kinase inhibitors: a patent review.Expert Opin Ther Pat. 2015 Apr;25(4):397-412. DMSMXK3 RU https://www.ncbi.nlm.nih.gov/pubmed/25656651 DMXBYHV DI DMXBYHV DMXBYHV DN Azaindole derivative 2 DMXBYHV MI TT3PJMV DMXBYHV MN Tyrosine-protein kinase ABL1 (ABL) DMXBYHV MT DTT DMXBYHV MA Inhibitor DMXBYHV RN Bcr-Abl tyrosine kinase inhibitors: a patent review.Expert Opin Ther Pat. 2015 Apr;25(4):397-412. DMXBYHV RU https://www.ncbi.nlm.nih.gov/pubmed/25656651 DM2EDOM DI DM2EDOM DM2EDOM DN Azaindole derivative 3 DM2EDOM MI TT7RJY8 DM2EDOM MN Xanthine dehydrogenase/oxidase (XDH) DM2EDOM MT DTT DM2EDOM MA Inhibitor DM2EDOM RN An updated patent review: xanthine oxidase inhibitors for the treatment of hyperuricemia and gout (2011-2015).Expert Opin Ther Pat. 2017 Mar;27(3):311-345. DM2EDOM RU https://www.ncbi.nlm.nih.gov/pubmed/27841045 DMCKSJ8 DI DMCKSJ8 DMCKSJ8 DN Azaindole derivative 4 DMCKSJ8 MI TT7RJY8 DMCKSJ8 MN Xanthine dehydrogenase/oxidase (XDH) DMCKSJ8 MT DTT DMCKSJ8 MA Inhibitor DMCKSJ8 RN An updated patent review: xanthine oxidase inhibitors for the treatment of hyperuricemia and gout (2011-2015).Expert Opin Ther Pat. 2017 Mar;27(3):311-345. DMCKSJ8 RU https://www.ncbi.nlm.nih.gov/pubmed/27841045 DMD2BL3 DI DMD2BL3 DMD2BL3 DN Azaindole derivative 5 DMD2BL3 MI TT7RJY8 DMD2BL3 MN Xanthine dehydrogenase/oxidase (XDH) DMD2BL3 MT DTT DMD2BL3 MA Inhibitor DMD2BL3 RN An updated patent review: xanthine oxidase inhibitors for the treatment of hyperuricemia and gout (2011-2015).Expert Opin Ther Pat. 2017 Mar;27(3):311-345. DMD2BL3 RU https://www.ncbi.nlm.nih.gov/pubmed/27841045 DMJBGHL DI DMJBGHL DMJBGHL DN Azaindole derivative 6 DMJBGHL MI TT7RJY8 DMJBGHL MN Xanthine dehydrogenase/oxidase (XDH) DMJBGHL MT DTT DMJBGHL MA Inhibitor DMJBGHL RN An updated patent review: xanthine oxidase inhibitors for the treatment of hyperuricemia and gout (2011-2015).Expert Opin Ther Pat. 2017 Mar;27(3):311-345. DMJBGHL RU https://www.ncbi.nlm.nih.gov/pubmed/27841045 DMA2JGU DI DMA2JGU DMA2JGU DN Azaindole derivative 7 DMA2JGU MI TT7RJY8 DMA2JGU MN Xanthine dehydrogenase/oxidase (XDH) DMA2JGU MT DTT DMA2JGU MA Inhibitor DMA2JGU RN An updated patent review: xanthine oxidase inhibitors for the treatment of hyperuricemia and gout (2011-2015).Expert Opin Ther Pat. 2017 Mar;27(3):311-345. DMA2JGU RU https://www.ncbi.nlm.nih.gov/pubmed/27841045 DMEUHCD DI DMEUHCD DMEUHCD DN Aza-phenalene-3-ketone derivative 1 DMEUHCD MI TTEBCY8 DMEUHCD MN Poly [ADP-ribose] polymerase (PARP) DMEUHCD MT DTT DMEUHCD MA Inhibitor DMEUHCD RN PARP inhibitors as antitumor agents: a patent update (2013-2015).Expert Opin Ther Pat. 2017 Mar;27(3):363-382. DMEUHCD RU https://www.ncbi.nlm.nih.gov/pubmed/27841036 DM76XH4 DI DM76XH4 DM76XH4 DN Azepan-4-one derivative 1 DM76XH4 MI TTZC0KV DM76XH4 MN Zinc finger-containing ubiquitin peptidase 1 (ZUP1) DM76XH4 MT DTT DM76XH4 MA Inhibitor DM76XH4 RN Deubiquitinases (DUBs) and DUB inhibitors: a patent review.Expert Opin Ther Pat. 2015;25(10):1191-1208. DM76XH4 RU https://www.ncbi.nlm.nih.gov/pubmed/26077642 DM7O0MD DI DM7O0MD DM7O0MD DN Azepan-4-one derivative 2 DM7O0MD MI TTZC0KV DM7O0MD MN Zinc finger-containing ubiquitin peptidase 1 (ZUP1) DM7O0MD MT DTT DM7O0MD MA Inhibitor DM7O0MD RN Deubiquitinases (DUBs) and DUB inhibitors: a patent review.Expert Opin Ther Pat. 2015;25(10):1191-1208. DM7O0MD RU https://www.ncbi.nlm.nih.gov/pubmed/26077642 DMXEFUD DI DMXEFUD DMXEFUD DN Azetidine derivative 1 DMXEFUD MI TT6OEDT DMXEFUD MN Cannabinoid receptor 1 (CB1) DMXEFUD MT DTT DMXEFUD MA Antagonist DMXEFUD RN A comprehensive patents review on cannabinoid 1 receptor antagonists as antiobesity agents. Expert Opin Ther Pat. 2015 Oct;25(10):1093-116. DMXEFUD RU https://pubmed.ncbi.nlm.nih.gov/26161824 DMTB3KS DI DMTB3KS DMTB3KS DN Azetidine derivative 2 DMTB3KS MI TTZCRP3 DMTB3KS MN ERK activator kinase (MEK) DMTB3KS MT DTT DMTB3KS MA Inhibitor DMTB3KS RN MEK inhibitors in oncology: a patent review (2015-Present).Expert Opin Ther Pat. 2017 Aug;27(8):887-906. DMTB3KS RU https://www.ncbi.nlm.nih.gov/pubmed/28594589 DMIKSVG DI DMIKSVG DMIKSVG DN Azetidine derivative 3 DMIKSVG MI TT6OEDT DMIKSVG MN Cannabinoid receptor 1 (CB1) DMIKSVG MT DTT DMIKSVG MA Antagonist DMIKSVG RN A comprehensive patents review on cannabinoid 1 receptor antagonists as antiobesity agents. Expert Opin Ther Pat. 2015 Oct;25(10):1093-116. DMIKSVG RU https://pubmed.ncbi.nlm.nih.gov/26161824 DMXL2V9 DI DMXL2V9 DMXL2V9 DN Azetidine derivative 4 DMXL2V9 MI TT6OEDT DMXL2V9 MN Cannabinoid receptor 1 (CB1) DMXL2V9 MT DTT DMXL2V9 MA Antagonist DMXL2V9 RN A comprehensive patents review on cannabinoid 1 receptor antagonists as antiobesity agents. Expert Opin Ther Pat. 2015 Oct;25(10):1093-116. DMXL2V9 RU https://pubmed.ncbi.nlm.nih.gov/26161824 DMJ9U0E DI DMJ9U0E DMJ9U0E DN Azetidine derivative 5 DMJ9U0E MI TTZJYKH DMJ9U0E MN Indoleamine 2,3-dioxygenase 1 (IDO1) DMJ9U0E MT DTT DMJ9U0E MA Inhibitor DMJ9U0E RN A patent review of IDO1 inhibitors for cancer.Expert Opin Ther Pat. 2018 Apr;28(4):317-330. DMJ9U0E RU https://www.ncbi.nlm.nih.gov/pubmed/29473428 DMH942E DI DMH942E DMH942E DN Azetidine urea derivative 1 DMH942E MI TTDP1UC DMH942E MN Fatty acid amide hydrolase (FAAH) DMH942E MT DTT DMH942E MA Inhibitor DMH942E RN Fatty acid amide hydrolase inhibitors: a patent review (2009-2014).Expert Opin Ther Pat. 2015;25(11):1247-66. DMH942E RU https://www.ncbi.nlm.nih.gov/pubmed/26413912 DMJY8XI DI DMJY8XI DMJY8XI DN Azetidine urea derivative 2 DMJY8XI MI TTDP1UC DMJY8XI MN Fatty acid amide hydrolase (FAAH) DMJY8XI MT DTT DMJY8XI MA Inhibitor DMJY8XI RN Fatty acid amide hydrolase inhibitors: a patent review (2009-2014).Expert Opin Ther Pat. 2015;25(11):1247-66. DMJY8XI RU https://www.ncbi.nlm.nih.gov/pubmed/26413912 DM48PIO DI DM48PIO DM48PIO DN Azetidine urea derivative 3 DM48PIO MI TTDP1UC DM48PIO MN Fatty acid amide hydrolase (FAAH) DM48PIO MT DTT DM48PIO MA Inhibitor DM48PIO RN Fatty acid amide hydrolase inhibitors: a patent review (2009-2014).Expert Opin Ther Pat. 2015;25(11):1247-66. DM48PIO RU https://www.ncbi.nlm.nih.gov/pubmed/26413912 DMZX8Y0 DI DMZX8Y0 DMZX8Y0 DN Azetidine-1-carboxamide derivative 1 DMZX8Y0 MI TT6OEDT DMZX8Y0 MN Cannabinoid receptor 1 (CB1) DMZX8Y0 MT DTT DMZX8Y0 MA Antagonist DMZX8Y0 RN A comprehensive patents review on cannabinoid 1 receptor antagonists as antiobesity agents. Expert Opin Ther Pat. 2015 Oct;25(10):1093-116. DMZX8Y0 RU https://pubmed.ncbi.nlm.nih.gov/26161824 DMONQ4L DI DMONQ4L DMONQ4L DN Azetidine-1-carboxamide derivative 2 DMONQ4L MI TT6OEDT DMONQ4L MN Cannabinoid receptor 1 (CB1) DMONQ4L MT DTT DMONQ4L MA Antagonist DMONQ4L RN A comprehensive patents review on cannabinoid 1 receptor antagonists as antiobesity agents. Expert Opin Ther Pat. 2015 Oct;25(10):1093-116. DMONQ4L RU https://pubmed.ncbi.nlm.nih.gov/26161824 DM2UGK3 DI DM2UGK3 DM2UGK3 DN Azetidine-1-carboxamide derivative 3 DM2UGK3 MI TT6OEDT DM2UGK3 MN Cannabinoid receptor 1 (CB1) DM2UGK3 MT DTT DM2UGK3 MA Antagonist DM2UGK3 RN A comprehensive patents review on cannabinoid 1 receptor antagonists as antiobesity agents. Expert Opin Ther Pat. 2015 Oct;25(10):1093-116. DM2UGK3 RU https://pubmed.ncbi.nlm.nih.gov/26161824 DMRMED4 DI DMRMED4 DMRMED4 DN Azetidine-benzoxazin-3(4H)-one derivative 1 DMRMED4 MI TTZ963I DMRMED4 MN Monoglyceride lipase (MAGL) DMRMED4 MT DTT DMRMED4 MA Inhibitor DMRMED4 RN A patent review of Monoacylglycerol Lipase (MAGL) inhibitors (2013-2017).Expert Opin Ther Pat. 2017 Dec;27(12):1341-1351. DMRMED4 RU https://www.ncbi.nlm.nih.gov/pubmed/29053063 DMMSPX7 DI DMMSPX7 DMMSPX7 DN Azetidine-benzoxazin-3(4H)-one derivative 2 DMMSPX7 MI TTZ963I DMMSPX7 MN Monoglyceride lipase (MAGL) DMMSPX7 MT DTT DMMSPX7 MA Inhibitor DMMSPX7 RN A patent review of Monoacylglycerol Lipase (MAGL) inhibitors (2013-2017).Expert Opin Ther Pat. 2017 Dec;27(12):1341-1351. DMMSPX7 RU https://www.ncbi.nlm.nih.gov/pubmed/29053063 DMA430E DI DMA430E DMA430E DN Azetidine-benzoxazin-3(4H)-one derivative 3 DMA430E MI TTZ963I DMA430E MN Monoglyceride lipase (MAGL) DMA430E MT DTT DMA430E MA Inhibitor DMA430E RN A patent review of Monoacylglycerol Lipase (MAGL) inhibitors (2013-2017).Expert Opin Ther Pat. 2017 Dec;27(12):1341-1351. DMA430E RU https://www.ncbi.nlm.nih.gov/pubmed/29053063 DMMWK3E DI DMMWK3E DMMWK3E DN Azetidinyl-piperazine derivative 1 DMMWK3E MI TTZ963I DMMWK3E MN Monoglyceride lipase (MAGL) DMMWK3E MT DTT DMMWK3E MA Inhibitor DMMWK3E RN A patent review of Monoacylglycerol Lipase (MAGL) inhibitors (2013-2017).Expert Opin Ther Pat. 2017 Dec;27(12):1341-1351. DMMWK3E RU https://www.ncbi.nlm.nih.gov/pubmed/29053063 DM0C48S DI DM0C48S DM0C48S DN Azetidinyl-piperazine derivative 2 DM0C48S MI TTZ963I DM0C48S MN Monoglyceride lipase (MAGL) DM0C48S MT DTT DM0C48S MA Inhibitor DM0C48S RN A patent review of Monoacylglycerol Lipase (MAGL) inhibitors (2013-2017).Expert Opin Ther Pat. 2017 Dec;27(12):1341-1351. DM0C48S RU https://www.ncbi.nlm.nih.gov/pubmed/29053063 DM3WHL2 DI DM3WHL2 DM3WHL2 DN Azetidinyl-piperazine derivative 3 DM3WHL2 MI TTZ963I DM3WHL2 MN Monoglyceride lipase (MAGL) DM3WHL2 MT DTT DM3WHL2 MA Inhibitor DM3WHL2 RN A patent review of Monoacylglycerol Lipase (MAGL) inhibitors (2013-2017).Expert Opin Ther Pat. 2017 Dec;27(12):1341-1351. DM3WHL2 RU https://www.ncbi.nlm.nih.gov/pubmed/29053063 DM0IJYQ DI DM0IJYQ DM0IJYQ DN Azetidinyl-piperidine derivative 1 DM0IJYQ MI TTZ963I DM0IJYQ MN Monoglyceride lipase (MAGL) DM0IJYQ MT DTT DM0IJYQ MA Inhibitor DM0IJYQ RN A patent review of Monoacylglycerol Lipase (MAGL) inhibitors (2013-2017).Expert Opin Ther Pat. 2017 Dec;27(12):1341-1351. DM0IJYQ RU https://www.ncbi.nlm.nih.gov/pubmed/29053063 DMNQLJU DI DMNQLJU DMNQLJU DN Azetidinyl-piperidine derivative 2 DMNQLJU MI TTZ963I DMNQLJU MN Monoglyceride lipase (MAGL) DMNQLJU MT DTT DMNQLJU MA Inhibitor DMNQLJU RN A patent review of Monoacylglycerol Lipase (MAGL) inhibitors (2013-2017).Expert Opin Ther Pat. 2017 Dec;27(12):1341-1351. DMNQLJU RU https://www.ncbi.nlm.nih.gov/pubmed/29053063 DM2UDV8 DI DM2UDV8 DM2UDV8 DN Azetidinyl-piperidine derivative 3 DM2UDV8 MI TTZ963I DM2UDV8 MN Monoglyceride lipase (MAGL) DM2UDV8 MT DTT DM2UDV8 MA Inhibitor DM2UDV8 RN A patent review of Monoacylglycerol Lipase (MAGL) inhibitors (2013-2017).Expert Opin Ther Pat. 2017 Dec;27(12):1341-1351. DM2UDV8 RU https://www.ncbi.nlm.nih.gov/pubmed/29053063 DM0E8YF DI DM0E8YF DM0E8YF DN Azole benzene derivative 1 DM0E8YF MI TT7RJY8 DM0E8YF MN Xanthine dehydrogenase/oxidase (XDH) DM0E8YF MT DTT DM0E8YF MA Inhibitor DM0E8YF RN An updated patent review: xanthine oxidase inhibitors for the treatment of hyperuricemia and gout (2011-2015).Expert Opin Ther Pat. 2017 Mar;27(3):311-345. DM0E8YF RU https://www.ncbi.nlm.nih.gov/pubmed/27841045 DMJG7M6 DI DMJG7M6 DMJG7M6 DN Azole benzene derivative 2 DMJG7M6 MI TT7RJY8 DMJG7M6 MN Xanthine dehydrogenase/oxidase (XDH) DMJG7M6 MT DTT DMJG7M6 MA Inhibitor DMJG7M6 RN An updated patent review: xanthine oxidase inhibitors for the treatment of hyperuricemia and gout (2011-2015).Expert Opin Ther Pat. 2017 Mar;27(3):311-345. DMJG7M6 RU https://www.ncbi.nlm.nih.gov/pubmed/27841045 DMH8Q4T DI DMH8Q4T DMH8Q4T DN Azole benzene derivative 3 DMH8Q4T MI TT7RJY8 DMH8Q4T MN Xanthine dehydrogenase/oxidase (XDH) DMH8Q4T MT DTT DMH8Q4T MA Inhibitor DMH8Q4T RN An updated patent review: xanthine oxidase inhibitors for the treatment of hyperuricemia and gout (2011-2015).Expert Opin Ther Pat. 2017 Mar;27(3):311-345. DMH8Q4T RU https://www.ncbi.nlm.nih.gov/pubmed/27841045 DMDPHT1 DI DMDPHT1 DMDPHT1 DN Azole benzene derivative 4 DMDPHT1 MI TT7RJY8 DMDPHT1 MN Xanthine dehydrogenase/oxidase (XDH) DMDPHT1 MT DTT DMDPHT1 MA Inhibitor DMDPHT1 RN An updated patent review: xanthine oxidase inhibitors for the treatment of hyperuricemia and gout (2011-2015).Expert Opin Ther Pat. 2017 Mar;27(3):311-345. DMDPHT1 RU https://www.ncbi.nlm.nih.gov/pubmed/27841045 DM76HXA DI DM76HXA DM76HXA DN Azole derivative 1 DM76HXA MI TTDP1UC DM76HXA MN Fatty acid amide hydrolase (FAAH) DM76HXA MT DTT DM76HXA MA Inhibitor DM76HXA RN Fatty acid amide hydrolase inhibitors: a patent review (2009-2014).Expert Opin Ther Pat. 2015;25(11):1247-66. DM76HXA RU https://www.ncbi.nlm.nih.gov/pubmed/26413912 DMOPNJ6 DI DMOPNJ6 DMOPNJ6 DN Azole derivative 2 DMOPNJ6 MI TTDP1UC DMOPNJ6 MN Fatty acid amide hydrolase (FAAH) DMOPNJ6 MT DTT DMOPNJ6 MA Inhibitor DMOPNJ6 RN Fatty acid amide hydrolase inhibitors: a patent review (2009-2014).Expert Opin Ther Pat. 2015;25(11):1247-66. DMOPNJ6 RU https://www.ncbi.nlm.nih.gov/pubmed/26413912 DMN9KTJ DI DMN9KTJ DMN9KTJ DN Azole derivative 3 DMN9KTJ MI TTDP1UC DMN9KTJ MN Fatty acid amide hydrolase (FAAH) DMN9KTJ MT DTT DMN9KTJ MA Inhibitor DMN9KTJ RN Fatty acid amide hydrolase inhibitors: a patent review (2009-2014).Expert Opin Ther Pat. 2015;25(11):1247-66. DMN9KTJ RU https://www.ncbi.nlm.nih.gov/pubmed/26413912 DMOW01E DI DMOW01E DMOW01E DN Azole derivative 4 DMOW01E MI TTDP1UC DMOW01E MN Fatty acid amide hydrolase (FAAH) DMOW01E MT DTT DMOW01E MA Inhibitor DMOW01E RN Fatty acid amide hydrolase inhibitors: a patent review (2009-2014).Expert Opin Ther Pat. 2015;25(11):1247-66. DMOW01E RU https://www.ncbi.nlm.nih.gov/pubmed/26413912 DM36QM5 DI DM36QM5 DM36QM5 DN Azole derivative 5 DM36QM5 MI TTDP1UC DM36QM5 MN Fatty acid amide hydrolase (FAAH) DM36QM5 MT DTT DM36QM5 MA Inhibitor DM36QM5 RN Fatty acid amide hydrolase inhibitors: a patent review (2009-2014).Expert Opin Ther Pat. 2015;25(11):1247-66. DM36QM5 RU https://www.ncbi.nlm.nih.gov/pubmed/26413912 DMTMJ7S DI DMTMJ7S DMTMJ7S DN Azole derivative 6 DMTMJ7S MI TTF8P9I DMTMJ7S MN Diacylglycerol acyltransferase 1 (DGAT1) DMTMJ7S MT DTT DMTMJ7S MA Inhibitor DMTMJ7S RN Acyltransferase inhibitors: a patent review (2010-present).Expert Opin Ther Pat. 2015 Feb;25(2):145-58. DMTMJ7S RU https://www.ncbi.nlm.nih.gov/pubmed/25470667 DMVUJGI DI DMVUJGI DMVUJGI DN Azole derivative 7 DMVUJGI MI TTF8P9I DMVUJGI MN Diacylglycerol acyltransferase 1 (DGAT1) DMVUJGI MT DTT DMVUJGI MA Inhibitor DMVUJGI RN Acyltransferase inhibitors: a patent review (2010-present).Expert Opin Ther Pat. 2015 Feb;25(2):145-58. DMVUJGI RU https://www.ncbi.nlm.nih.gov/pubmed/25470667 DM2DT6L DI DM2DT6L DM2DT6L DN BB 0223767 DM2DT6L MI TTOJ9QL DM2DT6L MN Endoplasmic reticulum to nucleus signaling 1 (ERN1) DM2DT6L MT DTT DM2DT6L MA Inhibitor DM2DT6L RN IRE-1 inhibitors. US8614253. DM2DT6L RU http://www.freepatentsonline.com/US8614253.html DMTWIE2 DI DMTWIE2 DMTWIE2 DN BC11-28 DMTWIE2 MI TTIS4OW DMTWIE2 MN Phosphodiesterase 8 (PDE8) DMTWIE2 MT DTT DMTWIE2 MA Inhibitor DMTWIE2 RN Inhibitors of phosphodiesterase 11 (PDE11). US9173884. DMTWIE2 RU http://www.freepatentsonline.com/US9173884.html DMZD6IJ DI DMZD6IJ DMZD6IJ DN BDBM108945 DMZD6IJ MI TTPKHTZ DMZD6IJ MN Activin receptor type IB (ACVR1B) DMZD6IJ MT DTT DMZD6IJ MA Inhibitor DMZD6IJ RN BMP inhibitors and methods of use thereof. US9682983. DMZD6IJ RU http://www.freepatentsonline.com/US9682983.html DMW5SD6 DI DMW5SD6 DMW5SD6 DN BDBM50011552 DMW5SD6 MI TT6NI13 DMW5SD6 MN MEK kinase kinase 4 (MAP4K4) DMW5SD6 MT DTT DMW5SD6 MA Inhibitor DMW5SD6 RN Aminoquinazoline and pyridopyrimidine derivatives. US9592235. DMW5SD6 RU http://www.freepatentsonline.com/US9592235.html DMHNYQU DI DMHNYQU DMHNYQU DN BDBM50011553 DMHNYQU MI TT6NI13 DMHNYQU MN MEK kinase kinase 4 (MAP4K4) DMHNYQU MT DTT DMHNYQU MA Inhibitor DMHNYQU RN Aminoquinazoline and pyridopyrimidine derivatives. US9592235. DMHNYQU RU http://www.freepatentsonline.com/US9592235.html DMA7JB6 DI DMA7JB6 DMA7JB6 DN BDBM50054344 DMA7JB6 MI TT369M5 DMA7JB6 MN Protein-tyrosine phosphatase SHP-1 (PTPN6) DMA7JB6 MT DTT DMA7JB6 MA Inhibitor DMA7JB6 RN Hydroxyindole carboxylic acid based inhibitors for oncogenic Src homology-2 domain containing protein tyrosine phosphatase-2 (SHP2). US9522881. DMA7JB6 RU http://www.freepatentsonline.com/US9522881.html DMQ4TUE DI DMQ4TUE DMQ4TUE DN BDBM50061601 DMQ4TUE MI TTCGOIN DMQ4TUE MN PIM-3 protein kinase (PIM3) DMQ4TUE MT DTT DMQ4TUE MA Inhibitor DMQ4TUE RN Azole compounds as PIM inhibitors. US9321756. DMQ4TUE RU http://www.freepatentsonline.com/US9321756.html DM3MRD9 DI DM3MRD9 DM3MRD9 DN BDBM50061608 DM3MRD9 MI TTCGOIN DM3MRD9 MN PIM-3 protein kinase (PIM3) DM3MRD9 MT DTT DM3MRD9 MA Inhibitor DM3MRD9 RN Azole compounds as PIM inhibitors. US9321756. DM3MRD9 RU http://www.freepatentsonline.com/US9321756.html DMM8IDC DI DMM8IDC DMM8IDC DN BDBM50061612 DMM8IDC MI TTCGOIN DMM8IDC MN PIM-3 protein kinase (PIM3) DMM8IDC MT DTT DMM8IDC MA Inhibitor DMM8IDC RN Azole compounds as PIM inhibitors. US9321756. DMM8IDC RU http://www.freepatentsonline.com/US9321756.html DM4I829 DI DM4I829 DM4I829 DN BDBM50080408 DM4I829 MI TTI1FPZ DM4I829 MN Epithelial discoidin domain receptor 1 (DDR1) DM4I829 MT DTT DM4I829 MA Inhibitor DM4I829 RN Quinazolinedione derivative. US9567304. DM4I829 RU http://www.freepatentsonline.com/US9567304.html DMJNOB9 DI DMJNOB9 DMJNOB9 DN BDBM50080559 DMJNOB9 MI TTDYP7I DMJNOB9 MN Sphingosine-1-phosphate receptor 3 (S1PR3) DMJNOB9 MT DTT DMJNOB9 MA Inhibitor DMJNOB9 RN Pyridin-4-yl derivatives. US9617250. DMJNOB9 RU http://www.freepatentsonline.com/US9617250.html DM3VNK0 DI DM3VNK0 DM3VNK0 DN BDBM50080563 DM3VNK0 MI TTDYP7I DM3VNK0 MN Sphingosine-1-phosphate receptor 3 (S1PR3) DM3VNK0 MT DTT DM3VNK0 MA Inhibitor DM3VNK0 RN Pyridin-4-yl derivatives. US9617250. DM3VNK0 RU http://www.freepatentsonline.com/US9617250.html DMLJU5P DI DMLJU5P DMLJU5P DN BDBM50080570 DMLJU5P MI TTDYP7I DMLJU5P MN Sphingosine-1-phosphate receptor 3 (S1PR3) DMLJU5P MT DTT DMLJU5P MA Inhibitor DMLJU5P RN Pyridin-4-yl derivatives. US9617250. DMLJU5P RU http://www.freepatentsonline.com/US9617250.html DMS7ZLK DI DMS7ZLK DMS7ZLK DN BDBM50158703 DMS7ZLK MI TTIG67W DMS7ZLK MN Lysine-specific demethylase 5A (KDM5A) DMS7ZLK MT DTT DMS7ZLK MA Inhibitor DMS7ZLK RN Histone demethylase inhibitors. US9714230. DMS7ZLK RU http://www.freepatentsonline.com/US9714230.html DMYJF70 DI DMYJF70 DMYJF70 DN BDBM50158755 DMYJF70 MI TTIG67W DMYJF70 MN Lysine-specific demethylase 5A (KDM5A) DMYJF70 MT DTT DMYJF70 MA Inhibitor DMYJF70 RN Histone demethylase inhibitors. US10173996. DMYJF70 RU http://www.freepatentsonline.com/US10173996.html DMU07MO DI DMU07MO DMU07MO DN BDBM50158791 DMU07MO MI TTIG67W DMU07MO MN Lysine-specific demethylase 5A (KDM5A) DMU07MO MT DTT DMU07MO MA Inhibitor DMU07MO RN Histone demethylase inhibitors. US9725441. DMU07MO RU http://www.freepatentsonline.com/US9725441.html DMWJZU9 DI DMWJZU9 DMWJZU9 DN BDBM50158794 DMWJZU9 MI TTIG67W DMWJZU9 MN Lysine-specific demethylase 5A (KDM5A) DMWJZU9 MT DTT DMWJZU9 MA Inhibitor DMWJZU9 RN Histone demethylase inhibitors. US10040779. DMWJZU9 RU http://www.freepatentsonline.com/US10040779.html DMTWI1H DI DMTWI1H DMTWI1H DN BDBM50158803 DMTWI1H MI TTIG67W DMTWI1H MN Lysine-specific demethylase 5A (KDM5A) DMTWI1H MT DTT DMTWI1H MA Inhibitor DMTWI1H RN Histone demethylase inhibitors. US9617242. DMTWI1H RU http://www.freepatentsonline.com/US9617242.html DMSTD28 DI DMSTD28 DMSTD28 DN BDBM50173306 DMSTD28 MI TTAZ3MN DMSTD28 MN Beta-adrenergic receptor kinase 1 (ADRBK1) DMSTD28 MT DTT DMSTD28 MA Inhibitor DMSTD28 RN G protein-coupled receptor kinase 2 inhibitors and methods for use of the same. US10023564. DMSTD28 RU http://www.freepatentsonline.com/US10023564.html DM7RTQP DI DM7RTQP DM7RTQP DN BDBM50173323 DM7RTQP MI TTTCXO0 DM7RTQP MN G protein-coupled receptor kinase 5 (GRK5) DM7RTQP MT DTT DM7RTQP MA Inhibitor DM7RTQP RN G protein-coupled receptor kinase 2 inhibitors and methods for use of the same. US10023564. DM7RTQP RU http://www.freepatentsonline.com/US10023564.html DMKEVDL DI DMKEVDL DMKEVDL DN BDBM50173327 DMKEVDL MI TTTCXO0 DMKEVDL MN G protein-coupled receptor kinase 5 (GRK5) DMKEVDL MT DTT DMKEVDL MA Inhibitor DMKEVDL RN G protein-coupled receptor kinase 2 inhibitors and methods for use of the same. US10023564. DMKEVDL RU http://www.freepatentsonline.com/US10023564.html DM1PU37 DI DM1PU37 DM1PU37 DN BDBM50173330 DM1PU37 MI TTTCXO0 DM1PU37 MN G protein-coupled receptor kinase 5 (GRK5) DM1PU37 MT DTT DM1PU37 MA Inhibitor DM1PU37 RN G protein-coupled receptor kinase 2 inhibitors and methods for use of the same. US10023564. DM1PU37 RU http://www.freepatentsonline.com/US10023564.html DM52IQF DI DM52IQF DM52IQF DN BDBM50177012 DM52IQF MI TTECBXN DM52IQF MN Oxysterols receptor LXR-alpha (NR1H3) DM52IQF MT DTT DM52IQF MA Inhibitor DM52IQF RN Piperazine derivatives as liver X receptor modulators. US10144715. DM52IQF RU http://www.freepatentsonline.com/US10144715.html DMEL28G DI DMEL28G DMEL28G DN BDBM50177019 DMEL28G MI TTECBXN DMEL28G MN Oxysterols receptor LXR-alpha (NR1H3) DMEL28G MT DTT DMEL28G MA Inhibitor DMEL28G RN Piperazine derivatives as liver X receptor modulators. US10144715. DMEL28G RU http://www.freepatentsonline.com/US10144715.html DM7TASJ DI DM7TASJ DM7TASJ DN BDBM50363773 DM7TASJ MI TTLKF5M DM7TASJ MN NAD-dependent deacetylase sirtuin-2 (SIRT2) DM7TASJ MT DTT DM7TASJ MA Inhibitor DM7TASJ RN Aroyl thiourea derivatives. US9365508. DM7TASJ RU http://www.freepatentsonline.com/US9365508.html DM46UPM DI DM46UPM DM46UPM DN BDBM50363780 DM46UPM MI TTLKF5M DM46UPM MN NAD-dependent deacetylase sirtuin-2 (SIRT2) DM46UPM MT DTT DM46UPM MA Inhibitor DM46UPM RN Aroyl thiourea derivatives. US9365508. DM46UPM RU http://www.freepatentsonline.com/US9365508.html DMUQI15 DI DMUQI15 DMUQI15 DN BDBM50363782 DMUQI15 MI TTLKF5M DMUQI15 MN NAD-dependent deacetylase sirtuin-2 (SIRT2) DMUQI15 MT DTT DMUQI15 MA Inhibitor DMUQI15 RN Aroyl thiourea derivatives. US9365508. DMUQI15 RU http://www.freepatentsonline.com/US9365508.html DMPOVZ6 DI DMPOVZ6 DMPOVZ6 DN BDBM50379214 DMPOVZ6 MI TTIET93 DMPOVZ6 MN Activated CDC42 kinase 1 (ACK-1) DMPOVZ6 MT DTT DMPOVZ6 MA Inhibitor DMPOVZ6 RN Kinase modulators for the treatment of cancer. US9416123. DMPOVZ6 RU http://www.freepatentsonline.com/US9416123.html DMQJ5S8 DI DMQJ5S8 DMQJ5S8 DN BDBM50382283 DMQJ5S8 MI TTOYT5L DMQJ5S8 MN Dipeptidyl-peptidase 7 (DPP7) DMQJ5S8 MT DTT DMQJ5S8 MA Inhibitor DMQJ5S8 RN FAP inhibitors. US9346814. DMQJ5S8 RU http://www.freepatentsonline.com/US9346814.html DM6DFTX DI DM6DFTX DM6DFTX DN BDBM50434164 DM6DFTX MI TTOYT5L DM6DFTX MN Dipeptidyl-peptidase 7 (DPP7) DM6DFTX MT DTT DM6DFTX MA Inhibitor DM6DFTX RN FAP inhibitors. US9346814. DM6DFTX RU http://www.freepatentsonline.com/US9346814.html DMDTYJ9 DI DMDTYJ9 DMDTYJ9 DN BDBM50434165 DMDTYJ9 MI TTOYT5L DMDTYJ9 MN Dipeptidyl-peptidase 7 (DPP7) DMDTYJ9 MT DTT DMDTYJ9 MA Inhibitor DMDTYJ9 RN FAP inhibitors. US9346814. DMDTYJ9 RU http://www.freepatentsonline.com/US9346814.html DM9GLQB DI DM9GLQB DM9GLQB DN BDBM50444058 DM9GLQB MI TTIEMFN DM9GLQB MN TYRO3 tyrosine kinase receptor (TYRO3) DM9GLQB MT DTT DM9GLQB MA Inhibitor DM9GLQB RN Therapeutic uses of selected pyrimidine compounds with anti-Mer tyrosine kinase activity. US9649309. DM9GLQB RU http://www.freepatentsonline.com/US9649309.html DMS0EMU DI DMS0EMU DMS0EMU DN BDBM50444059 DMS0EMU MI TTIEMFN DMS0EMU MN TYRO3 tyrosine kinase receptor (TYRO3) DMS0EMU MT DTT DMS0EMU MA Inhibitor DMS0EMU RN Therapeutic uses of selected pyrimidine compounds with anti-Mer tyrosine kinase activity. US9649309. DMS0EMU RU http://www.freepatentsonline.com/US9649309.html DMR2UGC DI DMR2UGC DMR2UGC DN BDBM50444062 DMR2UGC MI TTIEMFN DMR2UGC MN TYRO3 tyrosine kinase receptor (TYRO3) DMR2UGC MT DTT DMR2UGC MA Inhibitor DMR2UGC RN Therapeutic uses of selected pyrimidine compounds with anti-Mer tyrosine kinase activity. US9649309. DMR2UGC RU http://www.freepatentsonline.com/US9649309.html DMDOCTB DI DMDOCTB DMDOCTB DN Benzamide derivative 1 DMDOCTB MI TT9NXW4 DMDOCTB MN Sigma intracellular receptor 2 (TMEM97) DMDOCTB MT DTT DMDOCTB MA Ligand DMDOCTB RN Are sigma modulators an effective opportunity for cancer treatment A patent overview (1996-2016).Expert Opin Ther Pat. 2017 May;27(5):565-578. DMDOCTB RU https://www.ncbi.nlm.nih.gov/pubmed/28051882 DM9PKU2 DI DM9PKU2 DM9PKU2 DN Benzamide derivative 10 DM9PKU2 MI TT5TPI6 DM9PKU2 MN Opioid receptor sigma 1 (OPRS1) DM9PKU2 MT DTT DM9PKU2 MA Ligand DM9PKU2 RN The sigma-2 (-2) receptor: a review of recent patent applications: 2013-2018.Expert Opin Ther Pat. 2018 Sep;28(9):655-663. DM9PKU2 RU https://www.ncbi.nlm.nih.gov/pubmed/30185082 DM9PKU2 DI DM9PKU2 DM9PKU2 DN Benzamide derivative 10 DM9PKU2 MI TT9NXW4 DM9PKU2 MN Sigma intracellular receptor 2 (TMEM97) DM9PKU2 MT DTT DM9PKU2 MA Ligand DM9PKU2 RN The sigma-2 (-2) receptor: a review of recent patent applications: 2013-2018.Expert Opin Ther Pat. 2018 Sep;28(9):655-663. DM9PKU2 RU https://www.ncbi.nlm.nih.gov/pubmed/30185082 DM4V3Y5 DI DM4V3Y5 DM4V3Y5 DN Benzamide derivative 11 DM4V3Y5 MI TT5TPI6 DM4V3Y5 MN Opioid receptor sigma 1 (OPRS1) DM4V3Y5 MT DTT DM4V3Y5 MA Ligand DM4V3Y5 RN The sigma-2 (-2) receptor: a review of recent patent applications: 2013-2018.Expert Opin Ther Pat. 2018 Sep;28(9):655-663. DM4V3Y5 RU https://www.ncbi.nlm.nih.gov/pubmed/30185082 DM4V3Y5 DI DM4V3Y5 DM4V3Y5 DN Benzamide derivative 11 DM4V3Y5 MI TT9NXW4 DM4V3Y5 MN Sigma intracellular receptor 2 (TMEM97) DM4V3Y5 MT DTT DM4V3Y5 MA Ligand DM4V3Y5 RN The sigma-2 (-2) receptor: a review of recent patent applications: 2013-2018.Expert Opin Ther Pat. 2018 Sep;28(9):655-663. DM4V3Y5 RU https://www.ncbi.nlm.nih.gov/pubmed/30185082 DMS527F DI DMS527F DMS527F DN Benzamide derivative 12 DMS527F MI TT473XN DMS527F MN P2X purinoceptor 7 (P2RX7) DMS527F MT DTT DMS527F MA Antagonist DMS527F RN P2X7 receptor antagonists: a patent review (2010-2015).Expert Opin Ther Pat. 2017 Mar;27(3):257-267. DMS527F RU https://www.ncbi.nlm.nih.gov/pubmed/27724045 DMYSH9J DI DMYSH9J DMYSH9J DN Benzamide derivative 13 DMYSH9J MI TT473XN DMYSH9J MN P2X purinoceptor 7 (P2RX7) DMYSH9J MT DTT DMYSH9J MA Antagonist DMYSH9J RN P2X7 receptor antagonists: a patent review (2010-2015).Expert Opin Ther Pat. 2017 Mar;27(3):257-267. DMYSH9J RU https://www.ncbi.nlm.nih.gov/pubmed/27724045 DMP2LDC DI DMP2LDC DMP2LDC DN Benzamide derivative 14 DMP2LDC MI TTYLQ8V DMP2LDC MN Prostaglandin E synthase (PTGES) DMP2LDC MT DTT DMP2LDC MA Inhibitor DMP2LDC RN Microsomal prostaglandin E2 synthase-1 inhibitors: a patent review.Expert Opin Ther Pat. 2017 Sep;27(9):1047-1059. DMP2LDC RU https://www.ncbi.nlm.nih.gov/pubmed/28627961 DMAEBJ4 DI DMAEBJ4 DMAEBJ4 DN Benzamide derivative 15 DMAEBJ4 MI TTYLQ8V DMAEBJ4 MN Prostaglandin E synthase (PTGES) DMAEBJ4 MT DTT DMAEBJ4 MA Inhibitor DMAEBJ4 RN Microsomal prostaglandin E2 synthase-1 inhibitors: a patent review.Expert Opin Ther Pat. 2017 Sep;27(9):1047-1059. DMAEBJ4 RU https://www.ncbi.nlm.nih.gov/pubmed/28627961 DMOAXKF DI DMOAXKF DMOAXKF DN Benzamide derivative 16 DMOAXKF MI TTYLQ8V DMOAXKF MN Prostaglandin E synthase (PTGES) DMOAXKF MT DTT DMOAXKF MA Inhibitor DMOAXKF RN Microsomal prostaglandin E2 synthase-1 inhibitors: a patent review.Expert Opin Ther Pat. 2017 Sep;27(9):1047-1059. DMOAXKF RU https://www.ncbi.nlm.nih.gov/pubmed/28627961 DMD7640 DI DMD7640 DMD7640 DN Benzamide derivative 18 DMD7640 MI TTYLQ8V DMD7640 MN Prostaglandin E synthase (PTGES) DMD7640 MT DTT DMD7640 MA Inhibitor DMD7640 RN Microsomal prostaglandin E2 synthase-1 inhibitors: a patent review.Expert Opin Ther Pat. 2017 Sep;27(9):1047-1059. DMD7640 RU https://www.ncbi.nlm.nih.gov/pubmed/28627961 DM5YNTM DI DM5YNTM DM5YNTM DN Benzamide derivative 19 DM5YNTM MI TTF8P9I DM5YNTM MN Diacylglycerol acyltransferase 1 (DGAT1) DM5YNTM MT DTT DM5YNTM MA Inhibitor DM5YNTM RN Acyltransferase inhibitors: a patent review (2010-present).Expert Opin Ther Pat. 2015 Feb;25(2):145-58. DM5YNTM RU https://www.ncbi.nlm.nih.gov/pubmed/25470667 DM0UWNY DI DM0UWNY DM0UWNY DN Benzamide derivative 2 DM0UWNY MI TT9NXW4 DM0UWNY MN Sigma intracellular receptor 2 (TMEM97) DM0UWNY MT DTT DM0UWNY MA Ligand DM0UWNY RN Are sigma modulators an effective opportunity for cancer treatment A patent overview (1996-2016).Expert Opin Ther Pat. 2017 May;27(5):565-578. DM0UWNY RU https://www.ncbi.nlm.nih.gov/pubmed/28051882 DMFY78L DI DMFY78L DMFY78L DN Benzamide derivative 3 DMFY78L MI TT9NXW4 DMFY78L MN Sigma intracellular receptor 2 (TMEM97) DMFY78L MT DTT DMFY78L MA Ligand DMFY78L RN Are sigma modulators an effective opportunity for cancer treatment A patent overview (1996-2016).Expert Opin Ther Pat. 2017 May;27(5):565-578. DMFY78L RU https://www.ncbi.nlm.nih.gov/pubmed/28051882 DMNKYL9 DI DMNKYL9 DMNKYL9 DN Benzamide derivative 4 DMNKYL9 MI TT9NXW4 DMNKYL9 MN Sigma intracellular receptor 2 (TMEM97) DMNKYL9 MT DTT DMNKYL9 MA Ligand DMNKYL9 RN Are sigma modulators an effective opportunity for cancer treatment A patent overview (1996-2016).Expert Opin Ther Pat. 2017 May;27(5):565-578. DMNKYL9 RU https://www.ncbi.nlm.nih.gov/pubmed/28051882 DM6W0TM DI DM6W0TM DM6W0TM DN Benzamide derivative 5 DM6W0TM MI TTA6ZN2 DM6W0TM MN Nuclear factor erythroid 2-related factor 2 (Nrf2) DM6W0TM MT DTT DM6W0TM MA Inhibitor DM6W0TM RN Recent progress in the development of small molecule Nrf2 modulators: a patent review (2012-2016).Expert Opin Ther Pat. 2017 Jul;27(7):763-785. DM6W0TM RU https://www.ncbi.nlm.nih.gov/pubmed/28454500 DM80TDC DI DM80TDC DM80TDC DN Benzamide derivative 6 DM80TDC MI TTA6ZN2 DM80TDC MN Nuclear factor erythroid 2-related factor 2 (Nrf2) DM80TDC MT DTT DM80TDC MA Inhibitor DM80TDC RN Recent progress in the development of small molecule Nrf2 modulators: a patent review (2012-2016).Expert Opin Ther Pat. 2017 Jul;27(7):763-785. DM80TDC RU https://www.ncbi.nlm.nih.gov/pubmed/28454500 DM7UEJT DI DM7UEJT DM7UEJT DN Benzamide derivative 7 DM7UEJT MI TT5TPI6 DM7UEJT MN Opioid receptor sigma 1 (OPRS1) DM7UEJT MT DTT DM7UEJT MA Ligand DM7UEJT RN The sigma-2 (-2) receptor: a review of recent patent applications: 2013-2018.Expert Opin Ther Pat. 2018 Sep;28(9):655-663. DM7UEJT RU https://www.ncbi.nlm.nih.gov/pubmed/30185082 DM7UEJT DI DM7UEJT DM7UEJT DN Benzamide derivative 7 DM7UEJT MI TT9NXW4 DM7UEJT MN Sigma intracellular receptor 2 (TMEM97) DM7UEJT MT DTT DM7UEJT MA Ligand DM7UEJT RN The sigma-2 (-2) receptor: a review of recent patent applications: 2013-2018.Expert Opin Ther Pat. 2018 Sep;28(9):655-663. DM7UEJT RU https://www.ncbi.nlm.nih.gov/pubmed/30185082 DMAIJHC DI DMAIJHC DMAIJHC DN Benzamide derivative 8 DMAIJHC MI TT5TPI6 DMAIJHC MN Opioid receptor sigma 1 (OPRS1) DMAIJHC MT DTT DMAIJHC MA Ligand DMAIJHC RN The sigma-2 (-2) receptor: a review of recent patent applications: 2013-2018.Expert Opin Ther Pat. 2018 Sep;28(9):655-663. DMAIJHC RU https://www.ncbi.nlm.nih.gov/pubmed/30185082 DMAIJHC DI DMAIJHC DMAIJHC DN Benzamide derivative 8 DMAIJHC MI TT9NXW4 DMAIJHC MN Sigma intracellular receptor 2 (TMEM97) DMAIJHC MT DTT DMAIJHC MA Ligand DMAIJHC RN The sigma-2 (-2) receptor: a review of recent patent applications: 2013-2018.Expert Opin Ther Pat. 2018 Sep;28(9):655-663. DMAIJHC RU https://www.ncbi.nlm.nih.gov/pubmed/30185082 DMVFSJZ DI DMVFSJZ DMVFSJZ DN Benzamide derivative 9 DMVFSJZ MI TT5TPI6 DMVFSJZ MN Opioid receptor sigma 1 (OPRS1) DMVFSJZ MT DTT DMVFSJZ MA Ligand DMVFSJZ RN The sigma-2 (-2) receptor: a review of recent patent applications: 2013-2018.Expert Opin Ther Pat. 2018 Sep;28(9):655-663. DMVFSJZ RU https://www.ncbi.nlm.nih.gov/pubmed/30185082 DMVFSJZ DI DMVFSJZ DMVFSJZ DN Benzamide derivative 9 DMVFSJZ MI TT9NXW4 DMVFSJZ MN Sigma intracellular receptor 2 (TMEM97) DMVFSJZ MT DTT DMVFSJZ MA Ligand DMVFSJZ RN The sigma-2 (-2) receptor: a review of recent patent applications: 2013-2018.Expert Opin Ther Pat. 2018 Sep;28(9):655-663. DMVFSJZ RU https://www.ncbi.nlm.nih.gov/pubmed/30185082 DM4TOGU DI DM4TOGU DM4TOGU DN Benzanilide compound 1 DM4TOGU MI TTUX68I DM4TOGU MN Hypoxia-inducible factor 1 (HIF-1) DM4TOGU MT DTT DM4TOGU MA Inhibitor DM4TOGU RN Hypoxia-inducible factor (HIF) inhibitors: a patent survey (2011-2015).Expert Opin Ther Pat. 2016;26(3):309-22. DM4TOGU RU https://www.ncbi.nlm.nih.gov/pubmed/26882240 DMDM806 DI DMDM806 DMDM806 DN Benzanilide compound 2 DMDM806 MI TTUX68I DMDM806 MN Hypoxia-inducible factor 1 (HIF-1) DMDM806 MT DTT DMDM806 MA Inhibitor DMDM806 RN Hypoxia-inducible factor (HIF) inhibitors: a patent survey (2011-2015).Expert Opin Ther Pat. 2016;26(3):309-22. DMDM806 RU https://www.ncbi.nlm.nih.gov/pubmed/26882240 DMA3BCU DI DMA3BCU DMA3BCU DN Benzazepine derivative 1 DMA3BCU MI TTWJBZ5 DMA3BCU MN 5-HT 2C receptor (HTR2C) DMA3BCU MT DTT DMA3BCU MA Agonist DMA3BCU RN Novel serotonin receptor 2 (5-HT2R) agonists and antagonists: a patent review (2004-2014).Expert Opin Ther Pat. 2016;26(1):89-106. DMA3BCU RU https://www.ncbi.nlm.nih.gov/pubmed/26609882 DMKREJ2 DI DMKREJ2 DMKREJ2 DN Benzazepine derivative 2 DMKREJ2 MI TTWJBZ5 DMKREJ2 MN 5-HT 2C receptor (HTR2C) DMKREJ2 MT DTT DMKREJ2 MA Agonist DMKREJ2 RN Novel serotonin receptor 2 (5-HT2R) agonists and antagonists: a patent review (2004-2014).Expert Opin Ther Pat. 2016;26(1):89-106. DMKREJ2 RU https://www.ncbi.nlm.nih.gov/pubmed/26609882 DM3BGEN DI DM3BGEN DM3BGEN DN Benzazepine derivative 3 DM3BGEN MI TTWJBZ5 DM3BGEN MN 5-HT 2C receptor (HTR2C) DM3BGEN MT DTT DM3BGEN MA Agonist DM3BGEN RN Novel serotonin receptor 2 (5-HT2R) agonists and antagonists: a patent review (2004-2014).Expert Opin Ther Pat. 2016;26(1):89-106. DM3BGEN RU https://www.ncbi.nlm.nih.gov/pubmed/26609882 DMM72LS DI DMM72LS DMM72LS DN Benzazepine derivative 4 DMM72LS MI TTWJBZ5 DMM72LS MN 5-HT 2C receptor (HTR2C) DMM72LS MT DTT DMM72LS MA Agonist DMM72LS RN Novel serotonin receptor 2 (5-HT2R) agonists and antagonists: a patent review (2004-2014).Expert Opin Ther Pat. 2016;26(1):89-106. DMM72LS RU https://www.ncbi.nlm.nih.gov/pubmed/26609882 DM6XRDH DI DM6XRDH DM6XRDH DN Benzazepine derivative 5 DM6XRDH MI TTWJBZ5 DM6XRDH MN 5-HT 2C receptor (HTR2C) DM6XRDH MT DTT DM6XRDH MA Agonist DM6XRDH RN Novel serotonin receptor 2 (5-HT2R) agonists and antagonists: a patent review (2004-2014).Expert Opin Ther Pat. 2016;26(1):89-106. DM6XRDH RU https://www.ncbi.nlm.nih.gov/pubmed/26609882 DMCGX5S DI DMCGX5S DMCGX5S DN Benzazepine derivative 6 DMCGX5S MI TTWJBZ5 DMCGX5S MN 5-HT 2C receptor (HTR2C) DMCGX5S MT DTT DMCGX5S MA Agonist DMCGX5S RN Novel serotonin receptor 2 (5-HT2R) agonists and antagonists: a patent review (2004-2014).Expert Opin Ther Pat. 2016;26(1):89-106. DMCGX5S RU https://www.ncbi.nlm.nih.gov/pubmed/26609882 DM6PMZC DI DM6PMZC DM6PMZC DN Benzenamine derivative 1 DM6PMZC MI TTNR0UQ DM6PMZC MN Lysine-specific histone demethylase 1 (LSD) DM6PMZC MT DTT DM6PMZC MA Inhibitor DM6PMZC RN LSD1 inhibitors: a patent review (2010-2015).Expert Opin Ther Pat. 2016 May;26(5):565-80. DM6PMZC RU https://www.ncbi.nlm.nih.gov/pubmed/27019002 DMDZ7QS DI DMDZ7QS DMDZ7QS DN Benzenamine derivative 2 DMDZ7QS MI TTNR0UQ DMDZ7QS MN Lysine-specific histone demethylase 1 (LSD) DMDZ7QS MT DTT DMDZ7QS MA Inhibitor DMDZ7QS RN LSD1 inhibitors: a patent review (2010-2015).Expert Opin Ther Pat. 2016 May;26(5):565-80. DMDZ7QS RU https://www.ncbi.nlm.nih.gov/pubmed/27019002 DM8UXZ3 DI DM8UXZ3 DM8UXZ3 DN Benzenamine derivative 3 DM8UXZ3 MI TTNR0UQ DM8UXZ3 MN Lysine-specific histone demethylase 1 (LSD) DM8UXZ3 MT DTT DM8UXZ3 MA Inhibitor DM8UXZ3 RN LSD1 inhibitors: a patent review (2010-2015).Expert Opin Ther Pat. 2016 May;26(5):565-80. DM8UXZ3 RU https://www.ncbi.nlm.nih.gov/pubmed/27019002 DMQT7HV DI DMQT7HV DMQT7HV DN Benzenamine derivative 4 DMQT7HV MI TTNR0UQ DMQT7HV MN Lysine-specific histone demethylase 1 (LSD) DMQT7HV MT DTT DMQT7HV MA Inhibitor DMQT7HV RN LSD1 inhibitors: a patent review (2010-2015).Expert Opin Ther Pat. 2016 May;26(5):565-80. DMQT7HV RU https://www.ncbi.nlm.nih.gov/pubmed/27019002 DMB9VEH DI DMB9VEH DMB9VEH DN Benzene sulfonamide derivative 1 DMB9VEH MI TTIY56R DMB9VEH MN Kynurenine 3-hydroxylase (KMO) DMB9VEH MT DTT DMB9VEH MA Inhibitor DMB9VEH RN Inhibitors of the kynurenine pathway as neurotherapeutics: a patent review (2012-2015).Expert Opin Ther Pat. 2016 Jul;26(7):815-32. DMB9VEH RU https://www.ncbi.nlm.nih.gov/pubmed/27172114 DML9TF7 DI DML9TF7 DML9TF7 DN Benzene sulfonamide derivative 11 DML9TF7 MI TT4G2JS DML9TF7 MN Voltage-gated sodium channel alpha Nav1.7 (SCN9A) DML9TF7 MT DTT DML9TF7 MA Inhibitor DML9TF7 RN Sodium channel blockers: a patent review (2010 - 2014).Expert Opin Ther Pat. 2015 Mar;25(3):279-90. DML9TF7 RU https://www.ncbi.nlm.nih.gov/pubmed/25539043 DMESKY1 DI DMESKY1 DMESKY1 DN Benzene sulfonamide derivative 12 DMESKY1 MI TT4G2JS DMESKY1 MN Voltage-gated sodium channel alpha Nav1.7 (SCN9A) DMESKY1 MT DTT DMESKY1 MA Inhibitor DMESKY1 RN Sodium channel blockers: a patent review (2010 - 2014).Expert Opin Ther Pat. 2015 Mar;25(3):279-90. DMESKY1 RU https://www.ncbi.nlm.nih.gov/pubmed/25539043 DMFJTE9 DI DMFJTE9 DMFJTE9 DN Benzene sulfonamide derivative 15 DMFJTE9 MI TT4G2JS DMFJTE9 MN Voltage-gated sodium channel alpha Nav1.7 (SCN9A) DMFJTE9 MT DTT DMFJTE9 MA Blocker DMFJTE9 RN Sodium channel blockers: a patent review (2010 - 2014).Expert Opin Ther Pat. 2015 Mar;25(3):279-90. DMFJTE9 RU https://www.ncbi.nlm.nih.gov/pubmed/25539043 DMATBZW DI DMATBZW DMATBZW DN Benzene sulfonamide derivative 16 DMATBZW MI TTA592U DMATBZW MN Urate anion exchanger 1 (URAT1) DMATBZW MT DTT DMATBZW MA Inhibitor DMATBZW RN Urate transporter URAT1 inhibitors: a patent review (2012 - 2015).Expert Opin Ther Pat. 2016 Jul 30:1-10. DMATBZW RU https://www.ncbi.nlm.nih.gov/pubmed/27414413 DMUZQLR DI DMUZQLR DMUZQLR DN Benzene sulfonamide derivative 2 DMUZQLR MI TTIY56R DMUZQLR MN Kynurenine 3-hydroxylase (KMO) DMUZQLR MT DTT DMUZQLR MA Inhibitor DMUZQLR RN Inhibitors of the kynurenine pathway as neurotherapeutics: a patent review (2012-2015).Expert Opin Ther Pat. 2016 Jul;26(7):815-32. DMUZQLR RU https://www.ncbi.nlm.nih.gov/pubmed/27172114 DMCQLJY DI DMCQLJY DMCQLJY DN Benzene sulfonamide derivative 3 DMCQLJY MI TTIY56R DMCQLJY MN Kynurenine 3-hydroxylase (KMO) DMCQLJY MT DTT DMCQLJY MA Inhibitor DMCQLJY RN Inhibitors of the kynurenine pathway as neurotherapeutics: a patent review (2012-2015).Expert Opin Ther Pat. 2016 Jul;26(7):815-32. DMCQLJY RU https://www.ncbi.nlm.nih.gov/pubmed/27172114 DMXCUEG DI DMXCUEG DMXCUEG DN Benzene sulfonamide derivative 4 DMXCUEG MI TTIY56R DMXCUEG MN Kynurenine 3-hydroxylase (KMO) DMXCUEG MT DTT DMXCUEG MA Inhibitor DMXCUEG RN Inhibitors of the kynurenine pathway as neurotherapeutics: a patent review (2012-2015).Expert Opin Ther Pat. 2016 Jul;26(7):815-32. DMXCUEG RU https://www.ncbi.nlm.nih.gov/pubmed/27172114 DMW4NXV DI DMW4NXV DMW4NXV DN Benzene sulfonamide derivative 5 DMW4NXV MI TTIY56R DMW4NXV MN Kynurenine 3-hydroxylase (KMO) DMW4NXV MT DTT DMW4NXV MA Inhibitor DMW4NXV RN Inhibitors of the kynurenine pathway as neurotherapeutics: a patent review (2012-2015).Expert Opin Ther Pat. 2016 Jul;26(7):815-32. DMW4NXV RU https://www.ncbi.nlm.nih.gov/pubmed/27172114 DMD4UMP DI DMD4UMP DMD4UMP DN Benzene sulfonamide derivative 6 DMD4UMP MI TTIY56R DMD4UMP MN Kynurenine 3-hydroxylase (KMO) DMD4UMP MT DTT DMD4UMP MA Inhibitor DMD4UMP RN Inhibitors of the kynurenine pathway as neurotherapeutics: a patent review (2012-2015).Expert Opin Ther Pat. 2016 Jul;26(7):815-32. DMD4UMP RU https://www.ncbi.nlm.nih.gov/pubmed/27172114 DM0TKP2 DI DM0TKP2 DM0TKP2 DN Benzene sulfonamide derivative 7 DM0TKP2 MI TTIY56R DM0TKP2 MN Kynurenine 3-hydroxylase (KMO) DM0TKP2 MT DTT DM0TKP2 MA Inhibitor DM0TKP2 RN Inhibitors of the kynurenine pathway as neurotherapeutics: a patent review (2012-2015).Expert Opin Ther Pat. 2016 Jul;26(7):815-32. DM0TKP2 RU https://www.ncbi.nlm.nih.gov/pubmed/27172114 DMATU1X DI DMATU1X DMATU1X DN Benzene sulfonamide derivative 8 DMATU1X MI TTUX68I DMATU1X MN Hypoxia-inducible factor 1 (HIF-1) DMATU1X MT DTT DMATU1X MA Inhibitor DMATU1X RN Hypoxia-inducible factor (HIF) inhibitors: a patent survey (2011-2015).Expert Opin Ther Pat. 2016;26(3):309-22. DMATU1X RU https://www.ncbi.nlm.nih.gov/pubmed/26882240 DMLET14 DI DMLET14 DMLET14 DN Benzene sulfonamide derivative 9 DMLET14 MI TT4G2JS DMLET14 MN Voltage-gated sodium channel alpha Nav1.7 (SCN9A) DMLET14 MT DTT DMLET14 MA Blocker DMLET14 RN Sodium channel blockers: a patent review (2010 - 2014).Expert Opin Ther Pat. 2015 Mar;25(3):279-90. DMLET14 RU https://www.ncbi.nlm.nih.gov/pubmed/25539043 DM1IZA7 DI DM1IZA7 DM1IZA7 DN Benzimidazole DM1IZA7 MI TTSBVFO DM1IZA7 MN Dual-specificity tyrosine-phosphorylation regulated kinase 1A (DYRK1A) DM1IZA7 MT DTT DM1IZA7 MA Inhibitor DM1IZA7 RN Dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A) inhibitors: a survey of recent patent literature.Expert Opin Ther Pat. 2017 Nov;27(11):1183-1199. DM1IZA7 RU https://www.ncbi.nlm.nih.gov/pubmed/28766366 DM2G83R DI DM2G83R DM2G83R DN Benzimidazole and imadazopyridine carboximidamide compound 1 DM2G83R MI TTZJYKH DM2G83R MN Indoleamine 2,3-dioxygenase 1 (IDO1) DM2G83R MT DTT DM2G83R MA Inhibitor DM2G83R RN A patent review of IDO1 inhibitors for cancer.Expert Opin Ther Pat. 2018 Apr;28(4):317-330. DM2G83R RU https://www.ncbi.nlm.nih.gov/pubmed/29473428 DMJ2CIY DI DMJ2CIY DMJ2CIY DN Benzimidazole and imadazopyridine carboximidamide compound 2 DMJ2CIY MI TTZJYKH DMJ2CIY MN Indoleamine 2,3-dioxygenase 1 (IDO1) DMJ2CIY MT DTT DMJ2CIY MA Inhibitor DMJ2CIY RN A patent review of IDO1 inhibitors for cancer.Expert Opin Ther Pat. 2018 Apr;28(4):317-330. DMJ2CIY RU https://www.ncbi.nlm.nih.gov/pubmed/29473428 DMIXERP DI DMIXERP DMIXERP DN Benzimidazole and imidazopyridine derivative 1 DMIXERP MI TTCZOF2 DMIXERP MN Pyruvate dehydrogenase kinase 1 (PDHK1) DMIXERP MT DTT DMIXERP MA Inhibitor DMIXERP RN PDK1 disruptors and modulators: a patent review.Expert Opin Ther Pat. 2015 May;25(5):513-37. DMIXERP RU https://www.ncbi.nlm.nih.gov/pubmed/25684022 DMB1L32 DI DMB1L32 DMB1L32 DN Benzimidazole carboxamide derivative 1 DMB1L32 MI TTVDSZ0 DMB1L32 MN Poly [ADP-ribose] polymerase 1 (PARP1) DMB1L32 MT DTT DMB1L32 MA Inhibitor DMB1L32 RN PARP inhibitors as antitumor agents: a patent update (2013-2015).Expert Opin Ther Pat. 2017 Mar;27(3):363-382. DMB1L32 RU https://www.ncbi.nlm.nih.gov/pubmed/27841036 DML8W16 DI DML8W16 DML8W16 DN Benzimidazole derivative 1 DML8W16 MI TT6OEDT DML8W16 MN Cannabinoid receptor 1 (CB1) DML8W16 MT DTT DML8W16 MA Antagonist DML8W16 RN A comprehensive patents review on cannabinoid 1 receptor antagonists as antiobesity agents. Expert Opin Ther Pat. 2015 Oct;25(10):1093-116. DML8W16 RU https://pubmed.ncbi.nlm.nih.gov/26161824 DML3PE4 DI DML3PE4 DML3PE4 DN Benzimidazole derivative 10 DML3PE4 MI TTQR74A DML3PE4 MN Proteinase activated receptor 2 (PAR2) DML3PE4 MT DTT DML3PE4 MA Antagonist DML3PE4 RN Protease activated receptor 2 (PAR2) modulators: a patent review (2010-2015).Expert Opin Ther Pat. 2016;26(4):471-83. DML3PE4 RU https://www.ncbi.nlm.nih.gov/pubmed/26936077 DMGRD8B DI DMGRD8B DMGRD8B DN Benzimidazole derivative 11 DMGRD8B MI TTYLQ8V DMGRD8B MN Prostaglandin E synthase (PTGES) DMGRD8B MT DTT DMGRD8B MA Inhibitor DMGRD8B RN Microsomal prostaglandin E2 synthase-1 inhibitors: a patent review.Expert Opin Ther Pat. 2017 Sep;27(9):1047-1059. DMGRD8B RU https://www.ncbi.nlm.nih.gov/pubmed/28627961 DMOHERV DI DMOHERV DMOHERV DN Benzimidazole derivative 12 DMOHERV MI TTYLQ8V DMOHERV MN Prostaglandin E synthase (PTGES) DMOHERV MT DTT DMOHERV MA Inhibitor DMOHERV RN Microsomal prostaglandin E2 synthase-1 inhibitors: a patent review.Expert Opin Ther Pat. 2017 Sep;27(9):1047-1059. DMOHERV RU https://www.ncbi.nlm.nih.gov/pubmed/28627961 DMV4DQI DI DMV4DQI DMV4DQI DN Benzimidazole derivative 13 DMV4DQI MI TTYLQ8V DMV4DQI MN Prostaglandin E synthase (PTGES) DMV4DQI MT DTT DMV4DQI MA Inhibitor DMV4DQI RN Microsomal prostaglandin E2 synthase-1 inhibitors: a patent review.Expert Opin Ther Pat. 2017 Sep;27(9):1047-1059. DMV4DQI RU https://www.ncbi.nlm.nih.gov/pubmed/28627961 DMCY5M7 DI DMCY5M7 DMCY5M7 DN Benzimidazole derivative 14 DMCY5M7 MI TTYLQ8V DMCY5M7 MN Prostaglandin E synthase (PTGES) DMCY5M7 MT DTT DMCY5M7 MA Inhibitor DMCY5M7 RN Microsomal prostaglandin E2 synthase-1 inhibitors: a patent review.Expert Opin Ther Pat. 2017 Sep;27(9):1047-1059. DMCY5M7 RU https://www.ncbi.nlm.nih.gov/pubmed/28627961 DMJ3AZ4 DI DMJ3AZ4 DMJ3AZ4 DN Benzimidazole derivative 15 DMJ3AZ4 MI TTYLQ8V DMJ3AZ4 MN Prostaglandin E synthase (PTGES) DMJ3AZ4 MT DTT DMJ3AZ4 MA Inhibitor DMJ3AZ4 RN Microsomal prostaglandin E2 synthase-1 inhibitors: a patent review.Expert Opin Ther Pat. 2017 Sep;27(9):1047-1059. DMJ3AZ4 RU https://www.ncbi.nlm.nih.gov/pubmed/28627961 DMHEQDT DI DMHEQDT DMHEQDT DN Benzimidazole derivative 16 DMHEQDT MI TTYLQ8V DMHEQDT MN Prostaglandin E synthase (PTGES) DMHEQDT MT DTT DMHEQDT MA Inhibitor DMHEQDT RN Microsomal prostaglandin E2 synthase-1 inhibitors: a patent review.Expert Opin Ther Pat. 2017 Sep;27(9):1047-1059. DMHEQDT RU https://www.ncbi.nlm.nih.gov/pubmed/28627961 DM1DXME DI DM1DXME DM1DXME DN Benzimidazole derivative 17 DM1DXME MI TTYLQ8V DM1DXME MN Prostaglandin E synthase (PTGES) DM1DXME MT DTT DM1DXME MA Inhibitor DM1DXME RN Microsomal prostaglandin E2 synthase-1 inhibitors: a patent review.Expert Opin Ther Pat. 2017 Sep;27(9):1047-1059. DM1DXME RU https://www.ncbi.nlm.nih.gov/pubmed/28627961 DM4ZUDY DI DM4ZUDY DM4ZUDY DN Benzimidazole derivative 2 DM4ZUDY MI TT6OEDT DM4ZUDY MN Cannabinoid receptor 1 (CB1) DM4ZUDY MT DTT DM4ZUDY MA Antagonist DM4ZUDY RN A comprehensive patents review on cannabinoid 1 receptor antagonists as antiobesity agents. Expert Opin Ther Pat. 2015 Oct;25(10):1093-116. DM4ZUDY RU https://pubmed.ncbi.nlm.nih.gov/26161824 DMY93WG DI DMY93WG DMY93WG DN Benzimidazole derivative 3 DMY93WG MI TTULVH8 DMY93WG MN Tyrosinase (TYR) DMY93WG MT DTT DMY93WG MA Inhibitor DMY93WG RN Tyrosinase inhibitors: a patent review (2011-2015).Expert Opin Ther Pat. 2016;26(3):347-62. DMY93WG RU https://www.ncbi.nlm.nih.gov/pubmed/26815044 DM9PL3F DI DM9PL3F DM9PL3F DN Benzimidazole derivative 4 DM9PL3F MI TTULVH8 DM9PL3F MN Tyrosinase (TYR) DM9PL3F MT DTT DM9PL3F MA Inhibitor DM9PL3F RN Tyrosinase inhibitors: a patent review (2011-2015).Expert Opin Ther Pat. 2016;26(3):347-62. DM9PL3F RU https://www.ncbi.nlm.nih.gov/pubmed/26815044 DMWOJLX DI DMWOJLX DMWOJLX DN Benzimidazole derivative 5 DMWOJLX MI TTT7PJU DMWOJLX MN Janus kinase 3 (JAK-3) DMWOJLX MT DTT DMWOJLX MA Inhibitor DMWOJLX RN Inhibitors of JAK-family kinases: an update on the patent literature 2013-2015, part 2.Expert Opin Ther Pat. 2017 Feb;27(2):145-161. DMWOJLX RU https://www.ncbi.nlm.nih.gov/pubmed/27774822 DMV7TMB DI DMV7TMB DMV7TMB DN Benzimidazole derivative 6 DMV7TMB MI TTPMQSO DMV7TMB MN ALK tyrosine kinase receptor (ALK) DMV7TMB MT DTT DMV7TMB MA Inhibitor DMV7TMB RN Tropomyosin receptor kinase inhibitors: an updated patent review for 2010-2016 - Part I.Expert Opin Ther Pat. 2017 Jun;27(6):733-751. DMV7TMB RU https://www.ncbi.nlm.nih.gov/pubmed/28270010 DMV7TMB DI DMV7TMB DMV7TMB DN Benzimidazole derivative 6 DMV7TMB MI TTTDVOJ DMV7TMB MN Tropomyosin-related kinase A (TrkA) DMV7TMB MT DTT DMV7TMB MA Inhibitor DMV7TMB RN Tropomyosin receptor kinase inhibitors: an updated patent review for 2010-2016 - Part I.Expert Opin Ther Pat. 2017 Jun;27(6):733-751. DMV7TMB RU https://www.ncbi.nlm.nih.gov/pubmed/28270010 DMDK4RI DI DMDK4RI DMDK4RI DN Benzimidazole derivative 7 DMDK4RI MI TT6DM01 DMDK4RI MN Janus kinase 1 (JAK-1) DMDK4RI MT DTT DMDK4RI MA Inhibitor DMDK4RI RN Inhibitors of JAK-family kinases: an update on the patent literature 2013-2015, part 1.Expert Opin Ther Pat. 2017 Feb;27(2):127-143. DMDK4RI RU https://www.ncbi.nlm.nih.gov/pubmed/27774824 DMDK4RI DI DMDK4RI DMDK4RI DN Benzimidazole derivative 7 DMDK4RI MI TTRMX3V DMDK4RI MN Janus kinase 2 (JAK-2) DMDK4RI MT DTT DMDK4RI MA Inhibitor DMDK4RI RN Inhibitors of JAK-family kinases: an update on the patent literature 2013-2015, part 1.Expert Opin Ther Pat. 2017 Feb;27(2):127-143. DMDK4RI RU https://www.ncbi.nlm.nih.gov/pubmed/27774824 DMDK4RI DI DMDK4RI DMDK4RI DN Benzimidazole derivative 7 DMDK4RI MI TTT7PJU DMDK4RI MN Janus kinase 3 (JAK-3) DMDK4RI MT DTT DMDK4RI MA Inhibitor DMDK4RI RN Inhibitors of JAK-family kinases: an update on the patent literature 2013-2015, part 1.Expert Opin Ther Pat. 2017 Feb;27(2):127-143. DMDK4RI RU https://www.ncbi.nlm.nih.gov/pubmed/27774824 DMDK4RI DI DMDK4RI DMDK4RI DN Benzimidazole derivative 7 DMDK4RI MI TTBYWP2 DMDK4RI MN TYK2 tyrosine kinase (TYK2) DMDK4RI MT DTT DMDK4RI MA Inhibitor DMDK4RI RN Inhibitors of JAK-family kinases: an update on the patent literature 2013-2015, part 1.Expert Opin Ther Pat. 2017 Feb;27(2):127-143. DMDK4RI RU https://www.ncbi.nlm.nih.gov/pubmed/27774824 DMQ75BN DI DMQ75BN DMQ75BN DN Benzimidazole derivative 8 DMQ75BN MI TTQR74A DMQ75BN MN Proteinase activated receptor 2 (PAR2) DMQ75BN MT DTT DMQ75BN MA Antagonist DMQ75BN RN Protease activated receptor 2 (PAR2) modulators: a patent review (2010-2015).Expert Opin Ther Pat. 2016;26(4):471-83. DMQ75BN RU https://www.ncbi.nlm.nih.gov/pubmed/26936077 DMHJ98M DI DMHJ98M DMHJ98M DN Benzimidazole derivative 9 DMHJ98M MI TTQR74A DMHJ98M MN Proteinase activated receptor 2 (PAR2) DMHJ98M MT DTT DMHJ98M MA Antagonist DMHJ98M RN Protease activated receptor 2 (PAR2) modulators: a patent review (2010-2015).Expert Opin Ther Pat. 2016;26(4):471-83. DMHJ98M RU https://www.ncbi.nlm.nih.gov/pubmed/26936077 DMRZELF DI DMRZELF DMRZELF DN Benzimidazolone acetamide derivative 1 DMRZELF MI TTPTXIN DMRZELF MN Translocator protein (TSPO) DMRZELF MT DTT DMRZELF MA Ligand DMRZELF RN Translocator protein (TSPO) ligands for the diagnosis or treatment of neurodegenerative diseases: a patent review (2010-2015; part 1).Expert Opin Ther Pat. 2016 Nov;26(11):1325-1351. DMRZELF RU https://www.ncbi.nlm.nih.gov/pubmed/27607364 DMD9VC1 DI DMD9VC1 DMD9VC1 DN Benzimidazolone acetamide derivative 2 DMD9VC1 MI TTPTXIN DMD9VC1 MN Translocator protein (TSPO) DMD9VC1 MT DTT DMD9VC1 MA Ligand DMD9VC1 RN Translocator protein (TSPO) ligands for the diagnosis or treatment of neurodegenerative diseases: a patent review (2010-2015; part 1).Expert Opin Ther Pat. 2016 Nov;26(11):1325-1351. DMD9VC1 RU https://www.ncbi.nlm.nih.gov/pubmed/27607364 DMF01AR DI DMF01AR DMF01AR DN Benzisoselenazolone difluorocytidine derivative 1 DMF01AR MI TTR7UJ3 DMF01AR MN Cytoplasmic thioredoxin reductase (TXNRD1) DMF01AR MT DTT DMF01AR MA Inhibitor DMF01AR RN Thioredoxin reductase inhibitors: a patent review.Expert Opin Ther Pat. 2017 May;27(5):547-556. DMF01AR RU https://www.ncbi.nlm.nih.gov/pubmed/27977313 DM4VXY1 DI DM4VXY1 DM4VXY1 DN Benzo(b)carbazol-11-one compound 1 DM4VXY1 MI TT4DXQT DM4VXY1 MN Proto-oncogene c-Ret (RET) DM4VXY1 MT DTT DM4VXY1 MA Inhibitor DM4VXY1 RN RET kinase inhibitors: a review of recent patents (2012-2015).Expert Opin Ther Pat. 2017 Jan;27(1):91-99. DM4VXY1 RU https://www.ncbi.nlm.nih.gov/pubmed/27646564 DMGCHW9 DI DMGCHW9 DMGCHW9 DN Benzo(b)carbazol-11-one compound 2 DMGCHW9 MI TT4DXQT DMGCHW9 MN Proto-oncogene c-Ret (RET) DMGCHW9 MT DTT DMGCHW9 MA Inhibitor DMGCHW9 RN RET kinase inhibitors: a review of recent patents (2012-2015).Expert Opin Ther Pat. 2017 Jan;27(1):91-99. DMGCHW9 RU https://www.ncbi.nlm.nih.gov/pubmed/27646564 DMGCHW9 DI DMGCHW9 DMGCHW9 DN Benzo(b)carbazol-11-one compound 2 DMGCHW9 MI TTY0WT7 DMGCHW9 MN RET G691S mutant (RET G691S) DMGCHW9 MT DTT DMGCHW9 MA Inhibitor DMGCHW9 RN RET kinase inhibitors: a review of recent patents (2012-2015).Expert Opin Ther Pat. 2017 Jan;27(1):91-99. DMGCHW9 RU https://www.ncbi.nlm.nih.gov/pubmed/27646564 DMGCHW9 DI DMGCHW9 DMGCHW9 DN Benzo(b)carbazol-11-one compound 2 DMGCHW9 MI TT5XA6U DMGCHW9 MN RET M918T mutant (RET M918T) DMGCHW9 MT DTT DMGCHW9 MA Inhibitor DMGCHW9 RN RET kinase inhibitors: a review of recent patents (2012-2015).Expert Opin Ther Pat. 2017 Jan;27(1):91-99. DMGCHW9 RU https://www.ncbi.nlm.nih.gov/pubmed/27646564 DMGCHW9 DI DMGCHW9 DMGCHW9 DN Benzo(b)carbazol-11-one compound 2 DMGCHW9 MI TT8BF4A DMGCHW9 MN RET S891A mutant (RET S891A) DMGCHW9 MT DTT DMGCHW9 MA Inhibitor DMGCHW9 RN RET kinase inhibitors: a review of recent patents (2012-2015).Expert Opin Ther Pat. 2017 Jan;27(1):91-99. DMGCHW9 RU https://www.ncbi.nlm.nih.gov/pubmed/27646564 DMGCHW9 DI DMGCHW9 DMGCHW9 DN Benzo(b)carbazol-11-one compound 2 DMGCHW9 MI TT2RTDH DMGCHW9 MN RET V804L mutant (RET V804L) DMGCHW9 MT DTT DMGCHW9 MA Inhibitor DMGCHW9 RN RET kinase inhibitors: a review of recent patents (2012-2015).Expert Opin Ther Pat. 2017 Jan;27(1):91-99. DMGCHW9 RU https://www.ncbi.nlm.nih.gov/pubmed/27646564 DMGCHW9 DI DMGCHW9 DMGCHW9 DN Benzo(b)carbazol-11-one compound 2 DMGCHW9 MI TTQV3NX DMGCHW9 MN RET V804M mutant (RET V804M) DMGCHW9 MT DTT DMGCHW9 MA Inhibitor DMGCHW9 RN RET kinase inhibitors: a review of recent patents (2012-2015).Expert Opin Ther Pat. 2017 Jan;27(1):91-99. DMGCHW9 RU https://www.ncbi.nlm.nih.gov/pubmed/27646564 DMGCHW9 DI DMGCHW9 DMGCHW9 DN Benzo(b)carbazol-11-one compound 2 DMGCHW9 MI TTB0IO2 DMGCHW9 MN RET Y791F mutant (RET Y791F) DMGCHW9 MT DTT DMGCHW9 MA Inhibitor DMGCHW9 RN RET kinase inhibitors: a review of recent patents (2012-2015).Expert Opin Ther Pat. 2017 Jan;27(1):91-99. DMGCHW9 RU https://www.ncbi.nlm.nih.gov/pubmed/27646564 DMKXD2V DI DMKXD2V DMKXD2V DN Benzo[d]oxazol-2(3H)-one derivative 1 DMKXD2V MI TTEX248 DMKXD2V MN Dopamine D2 receptor (D2R) DMKXD2V MT DTT DMKXD2V MA Ligand DMKXD2V RN Progress in the development of histamine H3 receptor antagonists/inverse agonists: a patent review (2013-2017).Expert Opin Ther Pat. 2018 Mar;28(3):175-196. DMKXD2V RU https://www.ncbi.nlm.nih.gov/pubmed/29334795 DMKXD2V DI DMKXD2V DMKXD2V DN Benzo[d]oxazol-2(3H)-one derivative 1 DMKXD2V MI TT9JNIC DMKXD2V MN Histamine H3 receptor (H3R) DMKXD2V MT DTT DMKXD2V MA Inhibitor DMKXD2V RN Progress in the development of histamine H3 receptor antagonists/inverse agonists: a patent review (2013-2017).Expert Opin Ther Pat. 2018 Mar;28(3):175-196. DMKXD2V RU https://www.ncbi.nlm.nih.gov/pubmed/29334795 DM47KWB DI DM47KWB DM47KWB DN Benzo[d]oxazol-2(3H)-one derivative 2 DM47KWB MI TTEX248 DM47KWB MN Dopamine D2 receptor (D2R) DM47KWB MT DTT DM47KWB MA Ligand DM47KWB RN Progress in the development of histamine H3 receptor antagonists/inverse agonists: a patent review (2013-2017).Expert Opin Ther Pat. 2018 Mar;28(3):175-196. DM47KWB RU https://www.ncbi.nlm.nih.gov/pubmed/29334795 DM47KWB DI DM47KWB DM47KWB DN Benzo[d]oxazol-2(3H)-one derivative 2 DM47KWB MI TT9JNIC DM47KWB MN Histamine H3 receptor (H3R) DM47KWB MT DTT DM47KWB MA Inhibitor DM47KWB RN Progress in the development of histamine H3 receptor antagonists/inverse agonists: a patent review (2013-2017).Expert Opin Ther Pat. 2018 Mar;28(3):175-196. DM47KWB RU https://www.ncbi.nlm.nih.gov/pubmed/29334795 DM3Z5UQ DI DM3Z5UQ DM3Z5UQ DN Benzo[d]oxazol-2(3H)-one derivative 3 DM3Z5UQ MI TTEX248 DM3Z5UQ MN Dopamine D2 receptor (D2R) DM3Z5UQ MT DTT DM3Z5UQ MA Ligand DM3Z5UQ RN Progress in the development of histamine H3 receptor antagonists/inverse agonists: a patent review (2013-2017).Expert Opin Ther Pat. 2018 Mar;28(3):175-196. DM3Z5UQ RU https://www.ncbi.nlm.nih.gov/pubmed/29334795 DM3Z5UQ DI DM3Z5UQ DM3Z5UQ DN Benzo[d]oxazol-2(3H)-one derivative 3 DM3Z5UQ MI TT9JNIC DM3Z5UQ MN Histamine H3 receptor (H3R) DM3Z5UQ MT DTT DM3Z5UQ MA Inhibitor DM3Z5UQ RN Progress in the development of histamine H3 receptor antagonists/inverse agonists: a patent review (2013-2017).Expert Opin Ther Pat. 2018 Mar;28(3):175-196. DM3Z5UQ RU https://www.ncbi.nlm.nih.gov/pubmed/29334795 DMNIPE6 DI DMNIPE6 DMNIPE6 DN Benzo[d]oxazole derivative 1 DMNIPE6 MI TTA6ZN2 DMNIPE6 MN Nuclear factor erythroid 2-related factor 2 (Nrf2) DMNIPE6 MT DTT DMNIPE6 MA Inhibitor DMNIPE6 RN Recent progress in the development of small molecule Nrf2 modulators: a patent review (2012-2016).Expert Opin Ther Pat. 2017 Jul;27(7):763-785. DMNIPE6 RU https://www.ncbi.nlm.nih.gov/pubmed/28454500 DMR5V2A DI DMR5V2A DMR5V2A DN Benzo[d]oxazole derivative 2 DMR5V2A MI TTA6ZN2 DMR5V2A MN Nuclear factor erythroid 2-related factor 2 (Nrf2) DMR5V2A MT DTT DMR5V2A MA Inhibitor DMR5V2A RN Recent progress in the development of small molecule Nrf2 modulators: a patent review (2012-2016).Expert Opin Ther Pat. 2017 Jul;27(7):763-785. DMR5V2A RU https://www.ncbi.nlm.nih.gov/pubmed/28454500 DM712Y0 DI DM712Y0 DM712Y0 DN Benzo[d]oxazole derivative 3 DM712Y0 MI TTA6ZN2 DM712Y0 MN Nuclear factor erythroid 2-related factor 2 (Nrf2) DM712Y0 MT DTT DM712Y0 MA Inhibitor DM712Y0 RN Recent progress in the development of small molecule Nrf2 modulators: a patent review (2012-2016).Expert Opin Ther Pat. 2017 Jul;27(7):763-785. DM712Y0 RU https://www.ncbi.nlm.nih.gov/pubmed/28454500 DM0RAC6 DI DM0RAC6 DM0RAC6 DN Benzo[d]oxazole derivative 4 DM0RAC6 MI TTA6ZN2 DM0RAC6 MN Nuclear factor erythroid 2-related factor 2 (Nrf2) DM0RAC6 MT DTT DM0RAC6 MA Inhibitor DM0RAC6 RN Recent progress in the development of small molecule Nrf2 modulators: a patent review (2012-2016).Expert Opin Ther Pat. 2017 Jul;27(7):763-785. DM0RAC6 RU https://www.ncbi.nlm.nih.gov/pubmed/28454500 DMFXC5L DI DMFXC5L DMFXC5L DN Benzodiazepine derivative 1 DMFXC5L MI TTPTXIN DMFXC5L MN Translocator protein (TSPO) DMFXC5L MT DTT DMFXC5L MA Ligand DMFXC5L RN Translocator protein (TSPO) ligands for the diagnosis or treatment of neurodegenerative diseases: a patent review (2010-2015; part 1).Expert Opin Ther Pat. 2016 Nov;26(11):1325-1351. DMFXC5L RU https://www.ncbi.nlm.nih.gov/pubmed/27607364 DM5ZGNK DI DM5ZGNK DM5ZGNK DN Benzodiazepine derivative 2 DM5ZGNK MI TTJGW1Z DM5ZGNK MN Phosphodiesterase 2A (PDE2A) DM5ZGNK MT DTT DM5ZGNK MA Inhibitor DM5ZGNK RN Towards selective phosphodiesterase 2A (PDE2A) inhibitors: a patent review (2010 - present).Expert Opin Ther Pat. 2016 Aug;26(8):933-46. DM5ZGNK RU https://www.ncbi.nlm.nih.gov/pubmed/27321640 DM249KU DI DM249KU DM249KU DN Benzodihydroisofuran derivative 1 DM249KU MI TTTJZ4M DM249KU MN Prolylcarboxypeptidase (PRCP) DM249KU MT DTT DM249KU MA Inhibitor DM249KU RN Prolylcarboxypeptidase (PrCP) inhibitors and the therapeutic uses thereof: a patent review.Expert Opin Ther Pat. 2017 Oct;27(10):1077-1088. DM249KU RU https://www.ncbi.nlm.nih.gov/pubmed/28699813 DMGK0FD DI DMGK0FD DMGK0FD DN Benzodihydroisofuran derivative 2 DMGK0FD MI TTTJZ4M DMGK0FD MN Prolylcarboxypeptidase (PRCP) DMGK0FD MT DTT DMGK0FD MA Inhibitor DMGK0FD RN Prolylcarboxypeptidase (PrCP) inhibitors and the therapeutic uses thereof: a patent review.Expert Opin Ther Pat. 2017 Oct;27(10):1077-1088. DMGK0FD RU https://www.ncbi.nlm.nih.gov/pubmed/28699813 DMF6B1I DI DMF6B1I DMF6B1I DN Benzodihydroisofuran derivative 3 DMF6B1I MI TTTJZ4M DMF6B1I MN Prolylcarboxypeptidase (PRCP) DMF6B1I MT DTT DMF6B1I MA Inhibitor DMF6B1I RN Prolylcarboxypeptidase (PrCP) inhibitors and the therapeutic uses thereof: a patent review.Expert Opin Ther Pat. 2017 Oct;27(10):1077-1088. DMF6B1I RU https://www.ncbi.nlm.nih.gov/pubmed/28699813 DM5IH2O DI DM5IH2O DM5IH2O DN Benzodihydroisofuran derivative 4 DM5IH2O MI TTTJZ4M DM5IH2O MN Prolylcarboxypeptidase (PRCP) DM5IH2O MT DTT DM5IH2O MA Inhibitor DM5IH2O RN Prolylcarboxypeptidase (PrCP) inhibitors and the therapeutic uses thereof: a patent review.Expert Opin Ther Pat. 2017 Oct;27(10):1077-1088. DM5IH2O RU https://www.ncbi.nlm.nih.gov/pubmed/28699813 DM4198Z DI DM4198Z DM4198Z DN Benzofurans derivative 1 DM4198Z MI TTA592U DM4198Z MN Urate anion exchanger 1 (URAT1) DM4198Z MT DTT DM4198Z MA Inhibitor DM4198Z RN Urate transporter URAT1 inhibitors: a patent review (2012 - 2015).Expert Opin Ther Pat. 2016 Jul 30:1-10. DM4198Z RU https://www.ncbi.nlm.nih.gov/pubmed/27414413 DM3K25J DI DM3K25J DM3K25J DN Benzoheterocyclic compound 1 DM3K25J MI TTZCRP3 DM3K25J MN ERK activator kinase (MEK) DM3K25J MT DTT DM3K25J MA Inhibitor DM3K25J RN MEK inhibitors in oncology: a patent review (2015-Present).Expert Opin Ther Pat. 2017 Aug;27(8):887-906. DM3K25J RU https://www.ncbi.nlm.nih.gov/pubmed/28594589 DM5ZKR2 DI DM5ZKR2 DM5ZKR2 DN Benzoic acid derivative 1 DM5ZKR2 MI TTA592U DM5ZKR2 MN Urate anion exchanger 1 (URAT1) DM5ZKR2 MT DTT DM5ZKR2 MA Inhibitor DM5ZKR2 RN Urate transporter URAT1 inhibitors: a patent review (2012 - 2015).Expert Opin Ther Pat. 2016 Jul 30:1-10. DM5ZKR2 RU https://www.ncbi.nlm.nih.gov/pubmed/27414413 DMND8R0 DI DMND8R0 DMND8R0 DN Benzoic acid linked peptide analog 1 DMND8R0 MI TTULVH8 DMND8R0 MN Tyrosinase (TYR) DMND8R0 MT DTT DMND8R0 MA Inhibitor DMND8R0 RN Tyrosinase inhibitors: a patent review (2011-2015).Expert Opin Ther Pat. 2016;26(3):347-62. DMND8R0 RU https://www.ncbi.nlm.nih.gov/pubmed/26815044 DMUBG20 DI DMUBG20 DMUBG20 DN Benzoic acid linked peptide analog 2 DMUBG20 MI TTULVH8 DMUBG20 MN Tyrosinase (TYR) DMUBG20 MT DTT DMUBG20 MA Inhibitor DMUBG20 RN Tyrosinase inhibitors: a patent review (2011-2015).Expert Opin Ther Pat. 2016;26(3):347-62. DMUBG20 RU https://www.ncbi.nlm.nih.gov/pubmed/26815044 DM42BU9 DI DM42BU9 DM42BU9 DN Benzoic acid linked peptide analog 3 DM42BU9 MI TTULVH8 DM42BU9 MN Tyrosinase (TYR) DM42BU9 MT DTT DM42BU9 MA Inhibitor DM42BU9 RN Tyrosinase inhibitors: a patent review (2011-2015).Expert Opin Ther Pat. 2016;26(3):347-62. DM42BU9 RU https://www.ncbi.nlm.nih.gov/pubmed/26815044 DMNX5EU DI DMNX5EU DMNX5EU DN Benzoic acid linked peptide analog 4 DMNX5EU MI TTULVH8 DMNX5EU MN Tyrosinase (TYR) DMNX5EU MT DTT DMNX5EU MA Inhibitor DMNX5EU RN Tyrosinase inhibitors: a patent review (2011-2015).Expert Opin Ther Pat. 2016;26(3):347-62. DMNX5EU RU https://www.ncbi.nlm.nih.gov/pubmed/26815044 DMNIZAR DI DMNIZAR DMNIZAR DN Benzoic acid linked peptide analog 5 DMNIZAR MI TTULVH8 DMNIZAR MN Tyrosinase (TYR) DMNIZAR MT DTT DMNIZAR MA Inhibitor DMNIZAR RN Tyrosinase inhibitors: a patent review (2011-2015).Expert Opin Ther Pat. 2016;26(3):347-62. DMNIZAR RU https://www.ncbi.nlm.nih.gov/pubmed/26815044 DMTHKES DI DMTHKES DMTHKES DN Benzoic acid linked peptide analog 6 DMTHKES MI TTULVH8 DMTHKES MN Tyrosinase (TYR) DMTHKES MT DTT DMTHKES MA Inhibitor DMTHKES RN Tyrosinase inhibitors: a patent review (2011-2015).Expert Opin Ther Pat. 2016;26(3):347-62. DMTHKES RU https://www.ncbi.nlm.nih.gov/pubmed/26815044 DMUJFCK DI DMUJFCK DMUJFCK DN Benzoimidazole derivative 1 DMUJFCK MI TTZCRP3 DMUJFCK MN ERK activator kinase (MEK) DMUJFCK MT DTT DMUJFCK MA Inhibitor DMUJFCK RN MEK inhibitors in oncology: a patent review (2015-Present).Expert Opin Ther Pat. 2017 Aug;27(8):887-906. DMUJFCK RU https://www.ncbi.nlm.nih.gov/pubmed/28594589 DMHX5VO DI DMHX5VO DMHX5VO DN Benzoimidazole derivative 2 DMHX5VO MI TTZCRP3 DMHX5VO MN ERK activator kinase (MEK) DMHX5VO MT DTT DMHX5VO MA Inhibitor DMHX5VO RN MEK inhibitors in oncology: a patent review (2015-Present).Expert Opin Ther Pat. 2017 Aug;27(8):887-906. DMHX5VO RU https://www.ncbi.nlm.nih.gov/pubmed/28594589 DMM9J34 DI DMM9J34 DMM9J34 DN Benzonaphthyridine derivative 1 DMM9J34 MI TTCZOF2 DMM9J34 MN Pyruvate dehydrogenase kinase 1 (PDHK1) DMM9J34 MT DTT DMM9J34 MA Inhibitor DMM9J34 RN PDK1 disruptors and modulators: a patent review.Expert Opin Ther Pat. 2015 May;25(5):513-37. DMM9J34 RU https://www.ncbi.nlm.nih.gov/pubmed/25684022 DMB74LZ DI DMB74LZ DMB74LZ DN Benzonaphthyridine derivative 2 DMB74LZ MI TTCZOF2 DMB74LZ MN Pyruvate dehydrogenase kinase 1 (PDHK1) DMB74LZ MT DTT DMB74LZ MA Inhibitor DMB74LZ RN PDK1 disruptors and modulators: a patent review.Expert Opin Ther Pat. 2015 May;25(5):513-37. DMB74LZ RU https://www.ncbi.nlm.nih.gov/pubmed/25684022 DM9FPK1 DI DM9FPK1 DM9FPK1 DN Benzothiazepine analog 1 DM9FPK1 MI TTPTXIN DM9FPK1 MN Translocator protein (TSPO) DM9FPK1 MT DTT DM9FPK1 MA Ligand DM9FPK1 RN Translocator protein (TSPO) ligands for the diagnosis or treatment of neurodegenerative diseases: a patent review (2010-2015; part 1).Expert Opin Ther Pat. 2016 Nov;26(11):1325-1351. DM9FPK1 RU https://www.ncbi.nlm.nih.gov/pubmed/27607364 DMR6XF4 DI DMR6XF4 DMR6XF4 DN Benzothiazepine analog 10 DMR6XF4 MI TTRA6BO DMR6XF4 MN Bromodomain-containing protein 4 (BRD4) DMR6XF4 MT DTT DMR6XF4 MA Inhibitor DMR6XF4 RN BET inhibitors in cancer therapeutics: a patent review.Expert Opin Ther Pat. 2016;26(4):505-22. DMR6XF4 RU https://www.ncbi.nlm.nih.gov/pubmed/26924192 DMVC51O DI DMVC51O DMVC51O DN Benzothiazepine analog 11 DMVC51O MI TTRA6BO DMVC51O MN Bromodomain-containing protein 4 (BRD4) DMVC51O MT DTT DMVC51O MA Inhibitor DMVC51O RN BET inhibitors in cancer therapeutics: a patent review.Expert Opin Ther Pat. 2016;26(4):505-22. DMVC51O RU https://www.ncbi.nlm.nih.gov/pubmed/26924192 DM7XQ18 DI DM7XQ18 DM7XQ18 DN Benzothiazepine analog 12 DM7XQ18 MI TTRA6BO DM7XQ18 MN Bromodomain-containing protein 4 (BRD4) DM7XQ18 MT DTT DM7XQ18 MA Inhibitor DM7XQ18 RN BET inhibitors in cancer therapeutics: a patent review.Expert Opin Ther Pat. 2016;26(4):505-22. DM7XQ18 RU https://www.ncbi.nlm.nih.gov/pubmed/26924192 DMZ3NSJ DI DMZ3NSJ DMZ3NSJ DN Benzothiazepine analog 2 DMZ3NSJ MI TTPTXIN DMZ3NSJ MN Translocator protein (TSPO) DMZ3NSJ MT DTT DMZ3NSJ MA Ligand DMZ3NSJ RN Translocator protein (TSPO) ligands for the diagnosis or treatment of neurodegenerative diseases: a patent review (2010-2015; part 1).Expert Opin Ther Pat. 2016 Nov;26(11):1325-1351. DMZ3NSJ RU https://www.ncbi.nlm.nih.gov/pubmed/27607364 DM24NZG DI DM24NZG DM24NZG DN Benzothiazepine analog 3 DM24NZG MI TTPTXIN DM24NZG MN Translocator protein (TSPO) DM24NZG MT DTT DM24NZG MA Ligand DM24NZG RN Translocator protein (TSPO) ligands for the diagnosis or treatment of neurodegenerative diseases: a patent review (2010-2015; part 1).Expert Opin Ther Pat. 2016 Nov;26(11):1325-1351. DM24NZG RU https://www.ncbi.nlm.nih.gov/pubmed/27607364 DMV4OTD DI DMV4OTD DMV4OTD DN Benzothiazepine analog 4 DMV4OTD MI TTPTXIN DMV4OTD MN Translocator protein (TSPO) DMV4OTD MT DTT DMV4OTD MA Ligand DMV4OTD RN Translocator protein (TSPO) ligands for the diagnosis or treatment of neurodegenerative diseases: a patent review (2010-2015; part 1).Expert Opin Ther Pat. 2016 Nov;26(11):1325-1351. DMV4OTD RU https://www.ncbi.nlm.nih.gov/pubmed/27607364 DMCH1WX DI DMCH1WX DMCH1WX DN Benzothiazepine analog 5 DMCH1WX MI TTPTXIN DMCH1WX MN Translocator protein (TSPO) DMCH1WX MT DTT DMCH1WX MA Ligand DMCH1WX RN Translocator protein (TSPO) ligands for the diagnosis or treatment of neurodegenerative diseases: a patent review (2010-2015; part 1).Expert Opin Ther Pat. 2016 Nov;26(11):1325-1351. DMCH1WX RU https://www.ncbi.nlm.nih.gov/pubmed/27607364 DMB5KLD DI DMB5KLD DMB5KLD DN Benzothiazepine analog 6 DMB5KLD MI TTPTXIN DMB5KLD MN Translocator protein (TSPO) DMB5KLD MT DTT DMB5KLD MA Ligand DMB5KLD RN Translocator protein (TSPO) ligands for the diagnosis or treatment of neurodegenerative diseases: a patent review (2010-2015; part 1).Expert Opin Ther Pat. 2016 Nov;26(11):1325-1351. DMB5KLD RU https://www.ncbi.nlm.nih.gov/pubmed/27607364 DM25ZY4 DI DM25ZY4 DM25ZY4 DN Benzothiazepine analog 7 DM25ZY4 MI TTPTXIN DM25ZY4 MN Translocator protein (TSPO) DM25ZY4 MT DTT DM25ZY4 MA Ligand DM25ZY4 RN Translocator protein (TSPO) ligands for the diagnosis or treatment of neurodegenerative diseases: a patent review (2010-2015; part 1).Expert Opin Ther Pat. 2016 Nov;26(11):1325-1351. DM25ZY4 RU https://www.ncbi.nlm.nih.gov/pubmed/27607364 DMAXDV5 DI DMAXDV5 DMAXDV5 DN Benzothiazepine analog 8 DMAXDV5 MI TTPTXIN DMAXDV5 MN Translocator protein (TSPO) DMAXDV5 MT DTT DMAXDV5 MA Ligand DMAXDV5 RN Translocator protein (TSPO) ligands for the diagnosis or treatment of neurodegenerative diseases: a patent review (2010-2015; part 1).Expert Opin Ther Pat. 2016 Nov;26(11):1325-1351. DMAXDV5 RU https://www.ncbi.nlm.nih.gov/pubmed/27607364 DMONDMG DI DMONDMG DMONDMG DN Benzothiazepine analog 9 DMONDMG MI TTPTXIN DMONDMG MN Translocator protein (TSPO) DMONDMG MT DTT DMONDMG MA Ligand DMONDMG RN Translocator protein (TSPO) ligands for the diagnosis or treatment of neurodegenerative diseases: a patent review (2010-2015; part 1).Expert Opin Ther Pat. 2016 Nov;26(11):1325-1351. DMONDMG RU https://www.ncbi.nlm.nih.gov/pubmed/27607364 DMMVHY4 DI DMMVHY4 DMMVHY4 DN Benzothiazine derivative 1 DMMVHY4 MI TT1LVF2 DMMVHY4 MN Cyclin-dependent kinase 9 (CDK9) DMMVHY4 MT DTT DMMVHY4 MA Inhibitor DMMVHY4 RN Cyclin-dependent kinase inhibitors for cancer therapy: a patent review (2009 - 2014).Expert Opin Ther Pat. 2015;25(9):953-70. DMMVHY4 RU https://www.ncbi.nlm.nih.gov/pubmed/26161698 DMMVHY4 DI DMMVHY4 DMMVHY4 DN Benzothiazine derivative 1 DMMVHY4 MI TTTN5QW DMMVHY4 MN Serine/threonine-protein kinase pim-1 (PIM1) DMMVHY4 MT DTT DMMVHY4 MA Inhibitor DMMVHY4 RN Cyclin-dependent kinase inhibitors for cancer therapy: a patent review (2009 - 2014).Expert Opin Ther Pat. 2015;25(9):953-70. DMMVHY4 RU https://www.ncbi.nlm.nih.gov/pubmed/26161698 DMJ51VZ DI DMJ51VZ DMJ51VZ DN Benzothiazine-carboxamide compound 1 DMJ51VZ MI TTQR74A DMJ51VZ MN Proteinase activated receptor 2 (PAR2) DMJ51VZ MT DTT DMJ51VZ MA Antagonist DMJ51VZ RN Protease activated receptor 2 (PAR2) modulators: a patent review (2010-2015).Expert Opin Ther Pat. 2016;26(4):471-83. DMJ51VZ RU https://www.ncbi.nlm.nih.gov/pubmed/26936077 DMMP2RT DI DMMP2RT DMMP2RT DN Benzothiazine-carboxamide compound 2 DMMP2RT MI TTQR74A DMMP2RT MN Proteinase activated receptor 2 (PAR2) DMMP2RT MT DTT DMMP2RT MA Antagonist DMMP2RT RN Protease activated receptor 2 (PAR2) modulators: a patent review (2010-2015).Expert Opin Ther Pat. 2016;26(4):471-83. DMMP2RT RU https://www.ncbi.nlm.nih.gov/pubmed/26936077 DMI31OD DI DMI31OD DMI31OD DN Benzothiazine-carboxamide compound 3 DMI31OD MI TTQR74A DMI31OD MN Proteinase activated receptor 2 (PAR2) DMI31OD MT DTT DMI31OD MA Antagonist DMI31OD RN Protease activated receptor 2 (PAR2) modulators: a patent review (2010-2015).Expert Opin Ther Pat. 2016;26(4):471-83. DMI31OD RU https://www.ncbi.nlm.nih.gov/pubmed/26936077 DMSR918 DI DMSR918 DMSR918 DN Benzothiazine-carboxamide compound 4 DMSR918 MI TTQR74A DMSR918 MN Proteinase activated receptor 2 (PAR2) DMSR918 MT DTT DMSR918 MA Antagonist DMSR918 RN Protease activated receptor 2 (PAR2) modulators: a patent review (2010-2015).Expert Opin Ther Pat. 2016;26(4):471-83. DMSR918 RU https://www.ncbi.nlm.nih.gov/pubmed/26936077 DMM7N5E DI DMM7N5E DMM7N5E DN Benzothiazine-carboxamide compound 5 DMM7N5E MI TTQR74A DMM7N5E MN Proteinase activated receptor 2 (PAR2) DMM7N5E MT DTT DMM7N5E MA Antagonist DMM7N5E RN Protease activated receptor 2 (PAR2) modulators: a patent review (2010-2015).Expert Opin Ther Pat. 2016;26(4):471-83. DMM7N5E RU https://www.ncbi.nlm.nih.gov/pubmed/26936077 DMW94IQ DI DMW94IQ DMW94IQ DN Benzothiazine-carboxamide compound 6 DMW94IQ MI TTQR74A DMW94IQ MN Proteinase activated receptor 2 (PAR2) DMW94IQ MT DTT DMW94IQ MA Antagonist DMW94IQ RN Protease activated receptor 2 (PAR2) modulators: a patent review (2010-2015).Expert Opin Ther Pat. 2016;26(4):471-83. DMW94IQ RU https://www.ncbi.nlm.nih.gov/pubmed/26936077 DMHXFCQ DI DMHXFCQ DMHXFCQ DN Benzothiazole analog 1 DMHXFCQ MI TTULVH8 DMHXFCQ MN Tyrosinase (TYR) DMHXFCQ MT DTT DMHXFCQ MA Inhibitor DMHXFCQ RN Tyrosinase inhibitors: a patent review (2011-2015).Expert Opin Ther Pat. 2016;26(3):347-62. DMHXFCQ RU https://www.ncbi.nlm.nih.gov/pubmed/26815044 DMUKNXF DI DMUKNXF DMUKNXF DN Benzothiazole analog 2 DMUKNXF MI TTULVH8 DMUKNXF MN Tyrosinase (TYR) DMUKNXF MT DTT DMUKNXF MA Inhibitor DMUKNXF RN Tyrosinase inhibitors: a patent review (2011-2015).Expert Opin Ther Pat. 2016;26(3):347-62. DMUKNXF RU https://www.ncbi.nlm.nih.gov/pubmed/26815044 DMDLY38 DI DMDLY38 DMDLY38 DN Benzothiazole analog 3 DMDLY38 MI TTULVH8 DMDLY38 MN Tyrosinase (TYR) DMDLY38 MT DTT DMDLY38 MA Inhibitor DMDLY38 RN Tyrosinase inhibitors: a patent review (2011-2015).Expert Opin Ther Pat. 2016;26(3):347-62. DMDLY38 RU https://www.ncbi.nlm.nih.gov/pubmed/26815044 DMNDAT0 DI DMNDAT0 DMNDAT0 DN Benzothiazole analog 4 DMNDAT0 MI TTULVH8 DMNDAT0 MN Tyrosinase (TYR) DMNDAT0 MT DTT DMNDAT0 MA Inhibitor DMNDAT0 RN Tyrosinase inhibitors: a patent review (2011-2015).Expert Opin Ther Pat. 2016;26(3):347-62. DMNDAT0 RU https://www.ncbi.nlm.nih.gov/pubmed/26815044 DMN1J09 DI DMN1J09 DMN1J09 DN Benzothiazole analog 5 DMN1J09 MI TTULVH8 DMN1J09 MN Tyrosinase (TYR) DMN1J09 MT DTT DMN1J09 MA Inhibitor DMN1J09 RN Tyrosinase inhibitors: a patent review (2011-2015).Expert Opin Ther Pat. 2016;26(3):347-62. DMN1J09 RU https://www.ncbi.nlm.nih.gov/pubmed/26815044 DMJDC5T DI DMJDC5T DMJDC5T DN Benzothiazoline derivative 1 DMJDC5T MI TTULVH8 DMJDC5T MN Tyrosinase (TYR) DMJDC5T MT DTT DMJDC5T MA Inhibitor DMJDC5T RN Tyrosinase inhibitors: a patent review (2011-2015).Expert Opin Ther Pat. 2016;26(3):347-62. DMJDC5T RU https://www.ncbi.nlm.nih.gov/pubmed/26815044 DMCO0ZS DI DMCO0ZS DMCO0ZS DN Benzotriazole derivative 1 DMCO0ZS MI TT2F4OL DMCO0ZS MN Tissue transglutaminase (TG2) DMCO0ZS MT DTT DMCO0ZS MA Inhibitor DMCO0ZS RN Transglutaminase inhibitors: a patent review.Expert Opin Ther Pat. 2016;26(1):49-63. DMCO0ZS RU https://www.ncbi.nlm.nih.gov/pubmed/26560530 DMIYXS8 DI DMIYXS8 DMIYXS8 DN Benzoxazepine analog 1 DMIYXS8 MI TTPTXIN DMIYXS8 MN Translocator protein (TSPO) DMIYXS8 MT DTT DMIYXS8 MA Ligand DMIYXS8 RN Translocator protein (TSPO) ligands for the diagnosis or treatment of neurodegenerative diseases: a patent review (2010-2015; part 1).Expert Opin Ther Pat. 2016 Nov;26(11):1325-1351. DMIYXS8 RU https://www.ncbi.nlm.nih.gov/pubmed/27607364 DM4FHTG DI DM4FHTG DM4FHTG DN Benzoxazinone derivative 2 DM4FHTG MI TT4319X DM4FHTG MN Kallikrein-4 (KLK4) DM4FHTG MT DTT DM4FHTG MA Inhibitor DM4FHTG RN Serine protease inhibitors to treat inflammation: a patent review (2011-2016).Expert Opin Ther Pat. 2018 Feb;28(2):93-110. DM4FHTG RU https://www.ncbi.nlm.nih.gov/pubmed/29171765 DM4FHTG DI DM4FHTG DM4FHTG DN Benzoxazinone derivative 2 DM4FHTG MI TT5L2VC DM4FHTG MN Kallikrein-related peptidase (KLK) DM4FHTG MT DTT DM4FHTG MA Inhibitor DM4FHTG RN Serine protease inhibitors to treat inflammation: a patent review (2011-2016).Expert Opin Ther Pat. 2018 Feb;28(2):93-110. DM4FHTG RU https://www.ncbi.nlm.nih.gov/pubmed/29171765 DMY01FU DI DMY01FU DMY01FU DN Benzoxazole derivative 1 DMY01FU MI TTDP1UC DMY01FU MN Fatty acid amide hydrolase (FAAH) DMY01FU MT DTT DMY01FU MA Inhibitor DMY01FU RN Fatty acid amide hydrolase inhibitors: a patent review (2009-2014).Expert Opin Ther Pat. 2015;25(11):1247-66. DMY01FU RU https://www.ncbi.nlm.nih.gov/pubmed/26413912 DMJBOL0 DI DMJBOL0 DMJBOL0 DN Benzoyl-piperidine derivative 1 DMJBOL0 MI TTJQOD7 DMJBOL0 MN 5-HT 2A receptor (HTR2A) DMJBOL0 MT DTT DMJBOL0 MA Antagonist DMJBOL0 RN Novel serotonin receptor 2 (5-HT2R) agonists and antagonists: a patent review (2004-2014).Expert Opin Ther Pat. 2016;26(1):89-106. DMJBOL0 RU https://www.ncbi.nlm.nih.gov/pubmed/26609882 DMFKX1M DI DMFKX1M DMFKX1M DN Benzoyl-piperidine derivative 2 DMFKX1M MI TTJQOD7 DMFKX1M MN 5-HT 2A receptor (HTR2A) DMFKX1M MT DTT DMFKX1M MA Antagonist DMFKX1M RN Novel serotonin receptor 2 (5-HT2R) agonists and antagonists: a patent review (2004-2014).Expert Opin Ther Pat. 2016;26(1):89-106. DMFKX1M RU https://www.ncbi.nlm.nih.gov/pubmed/26609882 DMOU84B DI DMOU84B DMOU84B DN Benzyl amine derivative 1 DMOU84B MI TT5L2VC DMOU84B MN Kallikrein-related peptidase (KLK) DMOU84B MT DTT DMOU84B MA Inhibitor DMOU84B RN Serine protease inhibitors to treat inflammation: a patent review (2011-2016).Expert Opin Ther Pat. 2018 Feb;28(2):93-110. DMOU84B RU https://www.ncbi.nlm.nih.gov/pubmed/29171765 DMFK7EL DI DMFK7EL DMFK7EL DN Benzyl amine derivative 2 DMFK7EL MI TT5L2VC DMFK7EL MN Kallikrein-related peptidase (KLK) DMFK7EL MT DTT DMFK7EL MA Inhibitor DMFK7EL RN Serine protease inhibitors to treat inflammation: a patent review (2011-2016).Expert Opin Ther Pat. 2018 Feb;28(2):93-110. DMFK7EL RU https://www.ncbi.nlm.nih.gov/pubmed/29171765 DM6PTOX DI DM6PTOX DM6PTOX DN Benzyl phenyl ether derivative 1 DM6PTOX MI TT23XQV DM6PTOX MN PD-1-PD-L1 interaction (PD-1/PD-L1 PPI) DM6PTOX MT DTT DM6PTOX MA Inhibitor DM6PTOX RN A patent review on PD-1/PD-L1 antagonists: small molecules, peptides, and macrocycles (2015-2018).Expert Opin Ther Pat. 2018 Sep;28(9):665-678. DM6PTOX RU https://www.ncbi.nlm.nih.gov/pubmed/30107136 DMMS4EI DI DMMS4EI DMMS4EI DN Benzyl phenyl ether derivative 2 DMMS4EI MI TT23XQV DMMS4EI MN PD-1-PD-L1 interaction (PD-1/PD-L1 PPI) DMMS4EI MT DTT DMMS4EI MA Inhibitor DMMS4EI RN A patent review on PD-1/PD-L1 antagonists: small molecules, peptides, and macrocycles (2015-2018).Expert Opin Ther Pat. 2018 Sep;28(9):665-678. DMMS4EI RU https://www.ncbi.nlm.nih.gov/pubmed/30107136 DMIAB94 DI DMIAB94 DMIAB94 DN Benzyl pyrrolyloxoacetamide derivative 1 DMIAB94 MI TTDP1UC DMIAB94 MN Fatty acid amide hydrolase (FAAH) DMIAB94 MT DTT DMIAB94 MA Inhibitor DMIAB94 RN Fatty acid amide hydrolase inhibitors: a patent review (2009-2014).Expert Opin Ther Pat. 2015;25(11):1247-66. DMIAB94 RU https://www.ncbi.nlm.nih.gov/pubmed/26413912 DMHOLQF DI DMHOLQF DMHOLQF DN Benzyl pyrrolyloxoacetamide derivative 2 DMHOLQF MI TTDP1UC DMHOLQF MN Fatty acid amide hydrolase (FAAH) DMHOLQF MT DTT DMHOLQF MA Inhibitor DMHOLQF RN Fatty acid amide hydrolase inhibitors: a patent review (2009-2014).Expert Opin Ther Pat. 2015;25(11):1247-66. DMHOLQF RU https://www.ncbi.nlm.nih.gov/pubmed/26413912 DMD7Z3H DI DMD7Z3H DMD7Z3H DN Benzylcinnamate DMD7Z3H MI TTGP7BY DMD7Z3H MN Monoamine oxidase type B (MAO-B) DMD7Z3H MT DTT DMD7Z3H MA Inhibitor DMD7Z3H RN Novel monoamine oxidase inhibitors: a patent review (2012 - 2014).Expert Opin Ther Pat. 2015 Jan;25(1):91-110. DMD7Z3H RU https://www.ncbi.nlm.nih.gov/pubmed/25399762 DMZKTHL DI DMZKTHL DMZKTHL DN Beta-cyclodextrin conjugate derivative 1 DMZKTHL MI TTTCRU2 DMZKTHL MN Bacterial Fimbrin D-mannose adhesin (Bact FimH) DMZKTHL MT DTT DMZKTHL MA Antagonist DMZKTHL RN Mannose-derived FimH antagonists: a promising anti-virulence therapeutic strategy for urinary tract infections and Crohn's disease.Expert Opin Ther Pat. 2016;26(2):175-97. DMZKTHL RU https://www.ncbi.nlm.nih.gov/pubmed/26651364 DM9W1FO DI DM9W1FO DM9W1FO DN Beta-cyclodextrin conjugate derivative 2 DM9W1FO MI TTTCRU2 DM9W1FO MN Bacterial Fimbrin D-mannose adhesin (Bact FimH) DM9W1FO MT DTT DM9W1FO MA Antagonist DM9W1FO RN Mannose-derived FimH antagonists: a promising anti-virulence therapeutic strategy for urinary tract infections and Crohn's disease.Expert Opin Ther Pat. 2016;26(2):175-97. DM9W1FO RU https://www.ncbi.nlm.nih.gov/pubmed/26651364 DMQJF4P DI DMQJF4P DMQJF4P DN Beta-cyclodextrin conjugate derivative 3 DMQJF4P MI TTTCRU2 DMQJF4P MN Bacterial Fimbrin D-mannose adhesin (Bact FimH) DMQJF4P MT DTT DMQJF4P MA Antagonist DMQJF4P RN Mannose-derived FimH antagonists: a promising anti-virulence therapeutic strategy for urinary tract infections and Crohn's disease.Expert Opin Ther Pat. 2016;26(2):175-97. DMQJF4P RU https://www.ncbi.nlm.nih.gov/pubmed/26651364 DMO9RE8 DI DMO9RE8 DMO9RE8 DN Beta-cyclodextrin conjugate derivative 4 DMO9RE8 MI TTTCRU2 DMO9RE8 MN Bacterial Fimbrin D-mannose adhesin (Bact FimH) DMO9RE8 MT DTT DMO9RE8 MA Antagonist DMO9RE8 RN Mannose-derived FimH antagonists: a promising anti-virulence therapeutic strategy for urinary tract infections and Crohn's disease.Expert Opin Ther Pat. 2016;26(2):175-97. DMO9RE8 RU https://www.ncbi.nlm.nih.gov/pubmed/26651364 DML2B7G DI DML2B7G DML2B7G DN Beta-cyclodextrin conjugate derivative 5 DML2B7G MI TTTCRU2 DML2B7G MN Bacterial Fimbrin D-mannose adhesin (Bact FimH) DML2B7G MT DTT DML2B7G MA Antagonist DML2B7G RN Mannose-derived FimH antagonists: a promising anti-virulence therapeutic strategy for urinary tract infections and Crohn's disease.Expert Opin Ther Pat. 2016;26(2):175-97. DML2B7G RU https://www.ncbi.nlm.nih.gov/pubmed/26651364 DMMCDR7 DI DMMCDR7 DMMCDR7 DN Betais-sulfonylamino derivative 1 DMMCDR7 MI TTYLQ8V DMMCDR7 MN Prostaglandin E synthase (PTGES) DMMCDR7 MT DTT DMMCDR7 MA Inhibitor DMMCDR7 RN Microsomal prostaglandin E2 synthase-1 inhibitors: a patent review.Expert Opin Ther Pat. 2017 Sep;27(9):1047-1059. DMMCDR7 RU https://www.ncbi.nlm.nih.gov/pubmed/28627961 DM5KTDY DI DM5KTDY DM5KTDY DN Beta-naphthylacetic acids derivative 1 DM5KTDY MI TT5ZWB6 DM5KTDY MN Dihydrodiol dehydrogenase type I (AKR1C3) DM5KTDY MT DTT DM5KTDY MA Inhibitor; Antagonist; Blocker DM5KTDY RN Aldo-Keto Reductase (AKR) 1C3 inhibitors: a patent review.Expert Opin Ther Pat. 2017 Dec;27(12):1329-1340. DM5KTDY RU https://www.ncbi.nlm.nih.gov/pubmed/28895472 DM8D3FG DI DM8D3FG DM8D3FG DN Beta-phe compound 1 DM8D3FG MI TTDIGC1 DM8D3FG MN Dipeptidyl peptidase 4 (DPP-4) DM8D3FG MT DTT DM8D3FG MA Inhibitor DM8D3FG RN DPP-4 inhibitors: a patent review (2012 - 2014).Expert Opin Ther Pat. 2015 Feb;25(2):209-36. DM8D3FG RU https://www.ncbi.nlm.nih.gov/pubmed/25482888 DM786OD DI DM786OD DM786OD DN Beta-phe compound 2 DM786OD MI TTDIGC1 DM786OD MN Dipeptidyl peptidase 4 (DPP-4) DM786OD MT DTT DM786OD MA Inhibitor DM786OD RN DPP-4 inhibitors: a patent review (2012 - 2014).Expert Opin Ther Pat. 2015 Feb;25(2):209-36. DM786OD RU https://www.ncbi.nlm.nih.gov/pubmed/25482888 DM0G8XP DI DM0G8XP DM0G8XP DN Beta-phe compound 3 DM0G8XP MI TTDIGC1 DM0G8XP MN Dipeptidyl peptidase 4 (DPP-4) DM0G8XP MT DTT DM0G8XP MA Inhibitor DM0G8XP RN DPP-4 inhibitors: a patent review (2012 - 2014).Expert Opin Ther Pat. 2015 Feb;25(2):209-36. DM0G8XP RU https://www.ncbi.nlm.nih.gov/pubmed/25482888 DM79WI1 DI DM79WI1 DM79WI1 DN Beta-phenyl-alpha,beta-unsaturated carbonyl derivative 1 DM79WI1 MI TTULVH8 DM79WI1 MN Tyrosinase (TYR) DM79WI1 MT DTT DM79WI1 MA Inhibitor DM79WI1 RN Tyrosinase inhibitors: a patent review (2011-2015).Expert Opin Ther Pat. 2016;26(3):347-62. DM79WI1 RU https://www.ncbi.nlm.nih.gov/pubmed/26815044 DMRXMCH DI DMRXMCH DMRXMCH DN Beta-phenyl-alpha,beta-unsaturated carbonyl derivative 10 DMRXMCH MI TTULVH8 DMRXMCH MN Tyrosinase (TYR) DMRXMCH MT DTT DMRXMCH MA Inhibitor DMRXMCH RN Tyrosinase inhibitors: a patent review (2011-2015).Expert Opin Ther Pat. 2016;26(3):347-62. DMRXMCH RU https://www.ncbi.nlm.nih.gov/pubmed/26815044 DMVPR1D DI DMVPR1D DMVPR1D DN Beta-phenyl-alpha,beta-unsaturated carbonyl derivative 11 DMVPR1D MI TTULVH8 DMVPR1D MN Tyrosinase (TYR) DMVPR1D MT DTT DMVPR1D MA Inhibitor DMVPR1D RN Tyrosinase inhibitors: a patent review (2011-2015).Expert Opin Ther Pat. 2016;26(3):347-62. DMVPR1D RU https://www.ncbi.nlm.nih.gov/pubmed/26815044 DMOHBCN DI DMOHBCN DMOHBCN DN Beta-phenyl-alpha,beta-unsaturated carbonyl derivative 12 DMOHBCN MI TTULVH8 DMOHBCN MN Tyrosinase (TYR) DMOHBCN MT DTT DMOHBCN MA Inhibitor DMOHBCN RN Tyrosinase inhibitors: a patent review (2011-2015).Expert Opin Ther Pat. 2016;26(3):347-62. DMOHBCN RU https://www.ncbi.nlm.nih.gov/pubmed/26815044 DMKDBQG DI DMKDBQG DMKDBQG DN Beta-phenyl-alpha,beta-unsaturated carbonyl derivative 13 DMKDBQG MI TTULVH8 DMKDBQG MN Tyrosinase (TYR) DMKDBQG MT DTT DMKDBQG MA Inhibitor DMKDBQG RN Tyrosinase inhibitors: a patent review (2011-2015).Expert Opin Ther Pat. 2016;26(3):347-62. DMKDBQG RU https://www.ncbi.nlm.nih.gov/pubmed/26815044 DMWUAXM DI DMWUAXM DMWUAXM DN Beta-phenyl-alpha,beta-unsaturated carbonyl derivative 14 DMWUAXM MI TTULVH8 DMWUAXM MN Tyrosinase (TYR) DMWUAXM MT DTT DMWUAXM MA Inhibitor DMWUAXM RN Tyrosinase inhibitors: a patent review (2011-2015).Expert Opin Ther Pat. 2016;26(3):347-62. DMWUAXM RU https://www.ncbi.nlm.nih.gov/pubmed/26815044 DMAEQ0I DI DMAEQ0I DMAEQ0I DN Beta-phenyl-alpha,beta-unsaturated carbonyl derivative 2 DMAEQ0I MI TTULVH8 DMAEQ0I MN Tyrosinase (TYR) DMAEQ0I MT DTT DMAEQ0I MA Inhibitor DMAEQ0I RN Tyrosinase inhibitors: a patent review (2011-2015).Expert Opin Ther Pat. 2016;26(3):347-62. DMAEQ0I RU https://www.ncbi.nlm.nih.gov/pubmed/26815044 DMGV8T9 DI DMGV8T9 DMGV8T9 DN Beta-phenyl-alpha,beta-unsaturated carbonyl derivative 3 DMGV8T9 MI TTULVH8 DMGV8T9 MN Tyrosinase (TYR) DMGV8T9 MT DTT DMGV8T9 MA Inhibitor DMGV8T9 RN Tyrosinase inhibitors: a patent review (2011-2015).Expert Opin Ther Pat. 2016;26(3):347-62. DMGV8T9 RU https://www.ncbi.nlm.nih.gov/pubmed/26815044 DMNQF9S DI DMNQF9S DMNQF9S DN Beta-phenyl-alpha,beta-unsaturated carbonyl derivative 4 DMNQF9S MI TTULVH8 DMNQF9S MN Tyrosinase (TYR) DMNQF9S MT DTT DMNQF9S MA Inhibitor DMNQF9S RN Tyrosinase inhibitors: a patent review (2011-2015).Expert Opin Ther Pat. 2016;26(3):347-62. DMNQF9S RU https://www.ncbi.nlm.nih.gov/pubmed/26815044 DMBC48K DI DMBC48K DMBC48K DN Beta-phenyl-alpha,beta-unsaturated carbonyl derivative 5 DMBC48K MI TTULVH8 DMBC48K MN Tyrosinase (TYR) DMBC48K MT DTT DMBC48K MA Inhibitor DMBC48K RN Tyrosinase inhibitors: a patent review (2011-2015).Expert Opin Ther Pat. 2016;26(3):347-62. DMBC48K RU https://www.ncbi.nlm.nih.gov/pubmed/26815044 DMK9XV8 DI DMK9XV8 DMK9XV8 DN Beta-phenyl-alpha,beta-unsaturated carbonyl derivative 6 DMK9XV8 MI TTULVH8 DMK9XV8 MN Tyrosinase (TYR) DMK9XV8 MT DTT DMK9XV8 MA Inhibitor DMK9XV8 RN Tyrosinase inhibitors: a patent review (2011-2015).Expert Opin Ther Pat. 2016;26(3):347-62. DMK9XV8 RU https://www.ncbi.nlm.nih.gov/pubmed/26815044 DMES41R DI DMES41R DMES41R DN Beta-phenyl-alpha,beta-unsaturated carbonyl derivative 7 DMES41R MI TTULVH8 DMES41R MN Tyrosinase (TYR) DMES41R MT DTT DMES41R MA Inhibitor DMES41R RN Tyrosinase inhibitors: a patent review (2011-2015).Expert Opin Ther Pat. 2016;26(3):347-62. DMES41R RU https://www.ncbi.nlm.nih.gov/pubmed/26815044 DMRIPVG DI DMRIPVG DMRIPVG DN Beta-phenyl-alpha,beta-unsaturated carbonyl derivative 8 DMRIPVG MI TTULVH8 DMRIPVG MN Tyrosinase (TYR) DMRIPVG MT DTT DMRIPVG MA Inhibitor DMRIPVG RN Tyrosinase inhibitors: a patent review (2011-2015).Expert Opin Ther Pat. 2016;26(3):347-62. DMRIPVG RU https://www.ncbi.nlm.nih.gov/pubmed/26815044 DM7U20W DI DM7U20W DM7U20W DN Beta-phenyl-alpha,beta-unsaturated carbonyl derivative 9 DM7U20W MI TTULVH8 DM7U20W MN Tyrosinase (TYR) DM7U20W MT DTT DM7U20W MA Inhibitor DM7U20W RN Tyrosinase inhibitors: a patent review (2011-2015).Expert Opin Ther Pat. 2016;26(3):347-62. DM7U20W RU https://www.ncbi.nlm.nih.gov/pubmed/26815044 DMJG1ZS DI DMJG1ZS DMJG1ZS DN Biaromatic compound 1 DMJG1ZS MI TTZMAO3 DMJG1ZS MN Peroxisome proliferator-activated receptor gamma (PPAR-gamma) DMJG1ZS MT DTT DMJG1ZS MA Agonist DMJG1ZS RN PPAR ligands and their therapeutic applications: a patent review (2008 - 2014).Expert Opin Ther Pat. 2015 Feb;25(2):175-91. DMJG1ZS RU https://www.ncbi.nlm.nih.gov/pubmed/25416646 DMHEAJQ DI DMHEAJQ DMHEAJQ DN Biaryl compound 1 DMHEAJQ MI TT5YPJF DMHEAJQ MN CD80-PD-L1 interaction (CD80/PD-L1 PPI) DMHEAJQ MT DTT DMHEAJQ MA Inhibitor DMHEAJQ RN A patent review on PD-1/PD-L1 antagonists: small molecules, peptides, and macrocycles (2015-2018).Expert Opin Ther Pat. 2018 Sep;28(9):665-678. DMHEAJQ RU https://www.ncbi.nlm.nih.gov/pubmed/30107136 DMHEAJQ DI DMHEAJQ DMHEAJQ DN Biaryl compound 1 DMHEAJQ MI TT23XQV DMHEAJQ MN PD-1-PD-L1 interaction (PD-1/PD-L1 PPI) DMHEAJQ MT DTT DMHEAJQ MA Inhibitor DMHEAJQ RN A patent review on PD-1/PD-L1 antagonists: small molecules, peptides, and macrocycles (2015-2018).Expert Opin Ther Pat. 2018 Sep;28(9):665-678. DMHEAJQ RU https://www.ncbi.nlm.nih.gov/pubmed/30107136 DMS8VYE DI DMS8VYE DMS8VYE DN Biaryl compound 2 DMS8VYE MI TT5YPJF DMS8VYE MN CD80-PD-L1 interaction (CD80/PD-L1 PPI) DMS8VYE MT DTT DMS8VYE MA Inhibitor DMS8VYE RN A patent review on PD-1/PD-L1 antagonists: small molecules, peptides, and macrocycles (2015-2018).Expert Opin Ther Pat. 2018 Sep;28(9):665-678. DMS8VYE RU https://www.ncbi.nlm.nih.gov/pubmed/30107136 DMS8VYE DI DMS8VYE DMS8VYE DN Biaryl compound 2 DMS8VYE MI TT23XQV DMS8VYE MN PD-1-PD-L1 interaction (PD-1/PD-L1 PPI) DMS8VYE MT DTT DMS8VYE MA Inhibitor DMS8VYE RN A patent review on PD-1/PD-L1 antagonists: small molecules, peptides, and macrocycles (2015-2018).Expert Opin Ther Pat. 2018 Sep;28(9):665-678. DMS8VYE RU https://www.ncbi.nlm.nih.gov/pubmed/30107136 DMX6YGS DI DMX6YGS DMX6YGS DN Biaryl mannoside derivative 1 DMX6YGS MI TTTCRU2 DMX6YGS MN Bacterial Fimbrin D-mannose adhesin (Bact FimH) DMX6YGS MT DTT DMX6YGS MA Antagonist DMX6YGS RN Mannose-derived FimH antagonists: a promising anti-virulence therapeutic strategy for urinary tract infections and Crohn's disease.Expert Opin Ther Pat. 2016;26(2):175-97. DMX6YGS RU https://www.ncbi.nlm.nih.gov/pubmed/26651364 DMPF37N DI DMPF37N DMPF37N DN Biaryl mannoside derivative 10 DMPF37N MI TTTCRU2 DMPF37N MN Bacterial Fimbrin D-mannose adhesin (Bact FimH) DMPF37N MT DTT DMPF37N MA Antagonist DMPF37N RN Mannose-derived FimH antagonists: a promising anti-virulence therapeutic strategy for urinary tract infections and Crohn's disease.Expert Opin Ther Pat. 2016;26(2):175-97. DMPF37N RU https://www.ncbi.nlm.nih.gov/pubmed/26651364 DMKES0G DI DMKES0G DMKES0G DN Biaryl mannoside derivative 11 DMKES0G MI TTTCRU2 DMKES0G MN Bacterial Fimbrin D-mannose adhesin (Bact FimH) DMKES0G MT DTT DMKES0G MA Antagonist DMKES0G RN Mannose-derived FimH antagonists: a promising anti-virulence therapeutic strategy for urinary tract infections and Crohn's disease.Expert Opin Ther Pat. 2016;26(2):175-97. DMKES0G RU https://www.ncbi.nlm.nih.gov/pubmed/26651364 DM5T29W DI DM5T29W DM5T29W DN Biaryl mannoside derivative 12 DM5T29W MI TTTCRU2 DM5T29W MN Bacterial Fimbrin D-mannose adhesin (Bact FimH) DM5T29W MT DTT DM5T29W MA Antagonist DM5T29W RN Mannose-derived FimH antagonists: a promising anti-virulence therapeutic strategy for urinary tract infections and Crohn's disease.Expert Opin Ther Pat. 2016;26(2):175-97. DM5T29W RU https://www.ncbi.nlm.nih.gov/pubmed/26651364 DM1Y8OM DI DM1Y8OM DM1Y8OM DN Biaryl mannoside derivative 13 DM1Y8OM MI TTTCRU2 DM1Y8OM MN Bacterial Fimbrin D-mannose adhesin (Bact FimH) DM1Y8OM MT DTT DM1Y8OM MA Antagonist DM1Y8OM RN Mannose-derived FimH antagonists: a promising anti-virulence therapeutic strategy for urinary tract infections and Crohn's disease.Expert Opin Ther Pat. 2016;26(2):175-97. DM1Y8OM RU https://www.ncbi.nlm.nih.gov/pubmed/26651364 DM4C5QY DI DM4C5QY DM4C5QY DN Biaryl mannoside derivative 14 DM4C5QY MI TTTCRU2 DM4C5QY MN Bacterial Fimbrin D-mannose adhesin (Bact FimH) DM4C5QY MT DTT DM4C5QY MA Antagonist DM4C5QY RN Mannose-derived FimH antagonists: a promising anti-virulence therapeutic strategy for urinary tract infections and Crohn's disease.Expert Opin Ther Pat. 2016;26(2):175-97. DM4C5QY RU https://www.ncbi.nlm.nih.gov/pubmed/26651364 DMKXT7H DI DMKXT7H DMKXT7H DN Biaryl mannoside derivative 15 DMKXT7H MI TTTCRU2 DMKXT7H MN Bacterial Fimbrin D-mannose adhesin (Bact FimH) DMKXT7H MT DTT DMKXT7H MA Antagonist DMKXT7H RN Mannose-derived FimH antagonists: a promising anti-virulence therapeutic strategy for urinary tract infections and Crohn's disease.Expert Opin Ther Pat. 2016;26(2):175-97. DMKXT7H RU https://www.ncbi.nlm.nih.gov/pubmed/26651364 DMP9742 DI DMP9742 DMP9742 DN Biaryl mannoside derivative 16 DMP9742 MI TTTCRU2 DMP9742 MN Bacterial Fimbrin D-mannose adhesin (Bact FimH) DMP9742 MT DTT DMP9742 MA Antagonist DMP9742 RN Mannose-derived FimH antagonists: a promising anti-virulence therapeutic strategy for urinary tract infections and Crohn's disease.Expert Opin Ther Pat. 2016;26(2):175-97. DMP9742 RU https://www.ncbi.nlm.nih.gov/pubmed/26651364 DMIXV6G DI DMIXV6G DMIXV6G DN Biaryl mannoside derivative 17 DMIXV6G MI TTTCRU2 DMIXV6G MN Bacterial Fimbrin D-mannose adhesin (Bact FimH) DMIXV6G MT DTT DMIXV6G MA Antagonist DMIXV6G RN Mannose-derived FimH antagonists: a promising anti-virulence therapeutic strategy for urinary tract infections and Crohn's disease.Expert Opin Ther Pat. 2016;26(2):175-97. DMIXV6G RU https://www.ncbi.nlm.nih.gov/pubmed/26651364 DMHOPE0 DI DMHOPE0 DMHOPE0 DN Biaryl mannoside derivative 18 DMHOPE0 MI TTTCRU2 DMHOPE0 MN Bacterial Fimbrin D-mannose adhesin (Bact FimH) DMHOPE0 MT DTT DMHOPE0 MA Antagonist DMHOPE0 RN Mannose-derived FimH antagonists: a promising anti-virulence therapeutic strategy for urinary tract infections and Crohn's disease.Expert Opin Ther Pat. 2016;26(2):175-97. DMHOPE0 RU https://www.ncbi.nlm.nih.gov/pubmed/26651364 DME8DQ0 DI DME8DQ0 DME8DQ0 DN Biaryl mannoside derivative 19 DME8DQ0 MI TTTCRU2 DME8DQ0 MN Bacterial Fimbrin D-mannose adhesin (Bact FimH) DME8DQ0 MT DTT DME8DQ0 MA Antagonist DME8DQ0 RN Mannose-derived FimH antagonists: a promising anti-virulence therapeutic strategy for urinary tract infections and Crohn's disease.Expert Opin Ther Pat. 2016;26(2):175-97. DME8DQ0 RU https://www.ncbi.nlm.nih.gov/pubmed/26651364 DMMB60X DI DMMB60X DMMB60X DN Biaryl mannoside derivative 2 DMMB60X MI TTTCRU2 DMMB60X MN Bacterial Fimbrin D-mannose adhesin (Bact FimH) DMMB60X MT DTT DMMB60X MA Antagonist DMMB60X RN Mannose-derived FimH antagonists: a promising anti-virulence therapeutic strategy for urinary tract infections and Crohn's disease.Expert Opin Ther Pat. 2016;26(2):175-97. DMMB60X RU https://www.ncbi.nlm.nih.gov/pubmed/26651364 DMNC5S0 DI DMNC5S0 DMNC5S0 DN Biaryl mannoside derivative 20 DMNC5S0 MI TTTCRU2 DMNC5S0 MN Bacterial Fimbrin D-mannose adhesin (Bact FimH) DMNC5S0 MT DTT DMNC5S0 MA Antagonist DMNC5S0 RN Mannose-derived FimH antagonists: a promising anti-virulence therapeutic strategy for urinary tract infections and Crohn's disease.Expert Opin Ther Pat. 2016;26(2):175-97. DMNC5S0 RU https://www.ncbi.nlm.nih.gov/pubmed/26651364 DMGSLHN DI DMGSLHN DMGSLHN DN Biaryl mannoside derivative 21 DMGSLHN MI TTTCRU2 DMGSLHN MN Bacterial Fimbrin D-mannose adhesin (Bact FimH) DMGSLHN MT DTT DMGSLHN MA Antagonist DMGSLHN RN Mannose-derived FimH antagonists: a promising anti-virulence therapeutic strategy for urinary tract infections and Crohn's disease.Expert Opin Ther Pat. 2016;26(2):175-97. DMGSLHN RU https://www.ncbi.nlm.nih.gov/pubmed/26651364 DMYLVB3 DI DMYLVB3 DMYLVB3 DN Biaryl mannoside derivative 22 DMYLVB3 MI TTTCRU2 DMYLVB3 MN Bacterial Fimbrin D-mannose adhesin (Bact FimH) DMYLVB3 MT DTT DMYLVB3 MA Antagonist DMYLVB3 RN Mannose-derived FimH antagonists: a promising anti-virulence therapeutic strategy for urinary tract infections and Crohn's disease.Expert Opin Ther Pat. 2016;26(2):175-97. DMYLVB3 RU https://www.ncbi.nlm.nih.gov/pubmed/26651364 DM2YVGH DI DM2YVGH DM2YVGH DN Biaryl mannoside derivative 23 DM2YVGH MI TTTCRU2 DM2YVGH MN Bacterial Fimbrin D-mannose adhesin (Bact FimH) DM2YVGH MT DTT DM2YVGH MA Antagonist DM2YVGH RN Mannose-derived FimH antagonists: a promising anti-virulence therapeutic strategy for urinary tract infections and Crohn's disease.Expert Opin Ther Pat. 2016;26(2):175-97. DM2YVGH RU https://www.ncbi.nlm.nih.gov/pubmed/26651364 DMF5TB4 DI DMF5TB4 DMF5TB4 DN Biaryl mannoside derivative 24 DMF5TB4 MI TTTCRU2 DMF5TB4 MN Bacterial Fimbrin D-mannose adhesin (Bact FimH) DMF5TB4 MT DTT DMF5TB4 MA Antagonist DMF5TB4 RN Mannose-derived FimH antagonists: a promising anti-virulence therapeutic strategy for urinary tract infections and Crohn's disease.Expert Opin Ther Pat. 2016;26(2):175-97. DMF5TB4 RU https://www.ncbi.nlm.nih.gov/pubmed/26651364 DMRM3E9 DI DMRM3E9 DMRM3E9 DN Biaryl mannoside derivative 25 DMRM3E9 MI TTTCRU2 DMRM3E9 MN Bacterial Fimbrin D-mannose adhesin (Bact FimH) DMRM3E9 MT DTT DMRM3E9 MA Antagonist DMRM3E9 RN Mannose-derived FimH antagonists: a promising anti-virulence therapeutic strategy for urinary tract infections and Crohn's disease.Expert Opin Ther Pat. 2016;26(2):175-97. DMRM3E9 RU https://www.ncbi.nlm.nih.gov/pubmed/26651364 DMYXLCJ DI DMYXLCJ DMYXLCJ DN Biaryl mannoside derivative 26 DMYXLCJ MI TTTCRU2 DMYXLCJ MN Bacterial Fimbrin D-mannose adhesin (Bact FimH) DMYXLCJ MT DTT DMYXLCJ MA Antagonist DMYXLCJ RN Mannose-derived FimH antagonists: a promising anti-virulence therapeutic strategy for urinary tract infections and Crohn's disease.Expert Opin Ther Pat. 2016;26(2):175-97. DMYXLCJ RU https://www.ncbi.nlm.nih.gov/pubmed/26651364 DMTDPHY DI DMTDPHY DMTDPHY DN Biaryl mannoside derivative 27 DMTDPHY MI TTTCRU2 DMTDPHY MN Bacterial Fimbrin D-mannose adhesin (Bact FimH) DMTDPHY MT DTT DMTDPHY MA Antagonist DMTDPHY RN Mannose-derived FimH antagonists: a promising anti-virulence therapeutic strategy for urinary tract infections and Crohn's disease.Expert Opin Ther Pat. 2016;26(2):175-97. DMTDPHY RU https://www.ncbi.nlm.nih.gov/pubmed/26651364 DMSNMZ2 DI DMSNMZ2 DMSNMZ2 DN Biaryl mannoside derivative 28 DMSNMZ2 MI TTTCRU2 DMSNMZ2 MN Bacterial Fimbrin D-mannose adhesin (Bact FimH) DMSNMZ2 MT DTT DMSNMZ2 MA Antagonist DMSNMZ2 RN Mannose-derived FimH antagonists: a promising anti-virulence therapeutic strategy for urinary tract infections and Crohn's disease.Expert Opin Ther Pat. 2016;26(2):175-97. DMSNMZ2 RU https://www.ncbi.nlm.nih.gov/pubmed/26651364 DMCLTY3 DI DMCLTY3 DMCLTY3 DN Biaryl mannoside derivative 29 DMCLTY3 MI TTTCRU2 DMCLTY3 MN Bacterial Fimbrin D-mannose adhesin (Bact FimH) DMCLTY3 MT DTT DMCLTY3 MA Antagonist DMCLTY3 RN Mannose-derived FimH antagonists: a promising anti-virulence therapeutic strategy for urinary tract infections and Crohn's disease.Expert Opin Ther Pat. 2016;26(2):175-97. DMCLTY3 RU https://www.ncbi.nlm.nih.gov/pubmed/26651364 DMAITK3 DI DMAITK3 DMAITK3 DN Biaryl mannoside derivative 3 DMAITK3 MI TTTCRU2 DMAITK3 MN Bacterial Fimbrin D-mannose adhesin (Bact FimH) DMAITK3 MT DTT DMAITK3 MA Antagonist DMAITK3 RN Mannose-derived FimH antagonists: a promising anti-virulence therapeutic strategy for urinary tract infections and Crohn's disease.Expert Opin Ther Pat. 2016;26(2):175-97. DMAITK3 RU https://www.ncbi.nlm.nih.gov/pubmed/26651364 DMPLAWQ DI DMPLAWQ DMPLAWQ DN Biaryl mannoside derivative 30 DMPLAWQ MI TTTCRU2 DMPLAWQ MN Bacterial Fimbrin D-mannose adhesin (Bact FimH) DMPLAWQ MT DTT DMPLAWQ MA Antagonist DMPLAWQ RN Mannose-derived FimH antagonists: a promising anti-virulence therapeutic strategy for urinary tract infections and Crohn's disease.Expert Opin Ther Pat. 2016;26(2):175-97. DMPLAWQ RU https://www.ncbi.nlm.nih.gov/pubmed/26651364 DMMPJ3E DI DMMPJ3E DMMPJ3E DN Biaryl mannoside derivative 31 DMMPJ3E MI TTTCRU2 DMMPJ3E MN Bacterial Fimbrin D-mannose adhesin (Bact FimH) DMMPJ3E MT DTT DMMPJ3E MA Antagonist DMMPJ3E RN Mannose-derived FimH antagonists: a promising anti-virulence therapeutic strategy for urinary tract infections and Crohn's disease.Expert Opin Ther Pat. 2016;26(2):175-97. DMMPJ3E RU https://www.ncbi.nlm.nih.gov/pubmed/26651364 DMVF63N DI DMVF63N DMVF63N DN Biaryl mannoside derivative 4 DMVF63N MI TTTCRU2 DMVF63N MN Bacterial Fimbrin D-mannose adhesin (Bact FimH) DMVF63N MT DTT DMVF63N MA Antagonist DMVF63N RN Mannose-derived FimH antagonists: a promising anti-virulence therapeutic strategy for urinary tract infections and Crohn's disease.Expert Opin Ther Pat. 2016;26(2):175-97. DMVF63N RU https://www.ncbi.nlm.nih.gov/pubmed/26651364 DMRS1WG DI DMRS1WG DMRS1WG DN Biaryl mannoside derivative 5 DMRS1WG MI TTTCRU2 DMRS1WG MN Bacterial Fimbrin D-mannose adhesin (Bact FimH) DMRS1WG MT DTT DMRS1WG MA Antagonist DMRS1WG RN Mannose-derived FimH antagonists: a promising anti-virulence therapeutic strategy for urinary tract infections and Crohn's disease.Expert Opin Ther Pat. 2016;26(2):175-97. DMRS1WG RU https://www.ncbi.nlm.nih.gov/pubmed/26651364 DMEWA7U DI DMEWA7U DMEWA7U DN Biaryl mannoside derivative 6 DMEWA7U MI TTTCRU2 DMEWA7U MN Bacterial Fimbrin D-mannose adhesin (Bact FimH) DMEWA7U MT DTT DMEWA7U MA Antagonist DMEWA7U RN Mannose-derived FimH antagonists: a promising anti-virulence therapeutic strategy for urinary tract infections and Crohn's disease.Expert Opin Ther Pat. 2016;26(2):175-97. DMEWA7U RU https://www.ncbi.nlm.nih.gov/pubmed/26651364 DMD7053 DI DMD7053 DMD7053 DN Biaryl mannoside derivative 7 DMD7053 MI TTTCRU2 DMD7053 MN Bacterial Fimbrin D-mannose adhesin (Bact FimH) DMD7053 MT DTT DMD7053 MA Antagonist DMD7053 RN Mannose-derived FimH antagonists: a promising anti-virulence therapeutic strategy for urinary tract infections and Crohn's disease.Expert Opin Ther Pat. 2016;26(2):175-97. DMD7053 RU https://www.ncbi.nlm.nih.gov/pubmed/26651364 DMWF2VG DI DMWF2VG DMWF2VG DN Biaryl mannoside derivative 8 DMWF2VG MI TTTCRU2 DMWF2VG MN Bacterial Fimbrin D-mannose adhesin (Bact FimH) DMWF2VG MT DTT DMWF2VG MA Antagonist DMWF2VG RN Mannose-derived FimH antagonists: a promising anti-virulence therapeutic strategy for urinary tract infections and Crohn's disease.Expert Opin Ther Pat. 2016;26(2):175-97. DMWF2VG RU https://www.ncbi.nlm.nih.gov/pubmed/26651364 DM1Q7AL DI DM1Q7AL DM1Q7AL DN Biaryl mannoside derivative 9 DM1Q7AL MI TTTCRU2 DM1Q7AL MN Bacterial Fimbrin D-mannose adhesin (Bact FimH) DM1Q7AL MT DTT DM1Q7AL MA Antagonist DM1Q7AL RN Mannose-derived FimH antagonists: a promising anti-virulence therapeutic strategy for urinary tract infections and Crohn's disease.Expert Opin Ther Pat. 2016;26(2):175-97. DM1Q7AL RU https://www.ncbi.nlm.nih.gov/pubmed/26651364 DMDK7LQ DI DMDK7LQ DMDK7LQ DN Bicarboxylic and tricarboxylic ethynyl derivative 1 DMDK7LQ MI TTHS256 DMDK7LQ MN Metabotropic glutamate receptor 5 (mGluR5) DMDK7LQ MT DTT DMDK7LQ MA Modulator DMDK7LQ RN mGlu5 negative allosteric modulators: a patent review (2013 - 2016).Expert Opin Ther Pat. 2017 Jun;27(6):691-706. DMDK7LQ RU https://www.ncbi.nlm.nih.gov/pubmed/28067079 DMG9O7D DI DMG9O7D DMG9O7D DN Bicarboxylic and tricarboxylic ethynyl derivative 2 DMG9O7D MI TTHS256 DMG9O7D MN Metabotropic glutamate receptor 5 (mGluR5) DMG9O7D MT DTT DMG9O7D MA Modulator DMG9O7D RN mGlu5 negative allosteric modulators: a patent review (2013 - 2016).Expert Opin Ther Pat. 2017 Jun;27(6):691-706. DMG9O7D RU https://www.ncbi.nlm.nih.gov/pubmed/28067079 DM1KVTZ DI DM1KVTZ DM1KVTZ DN Bicarboxylic and tricarboxylic ethynyl derivative 3 DM1KVTZ MI TTHS256 DM1KVTZ MN Metabotropic glutamate receptor 5 (mGluR5) DM1KVTZ MT DTT DM1KVTZ MA Modulator DM1KVTZ RN mGlu5 negative allosteric modulators: a patent review (2013 - 2016).Expert Opin Ther Pat. 2017 Jun;27(6):691-706. DM1KVTZ RU https://www.ncbi.nlm.nih.gov/pubmed/28067079 DMOFI09 DI DMOFI09 DMOFI09 DN Bicyclic heteroaryl amide derivative 1 DMOFI09 MI TT473XN DMOFI09 MN P2X purinoceptor 7 (P2RX7) DMOFI09 MT DTT DMOFI09 MA Antagonist DMOFI09 RN P2X7 receptor antagonists: a patent review (2010-2015).Expert Opin Ther Pat. 2017 Mar;27(3):257-267. DMOFI09 RU https://www.ncbi.nlm.nih.gov/pubmed/27724045 DM69HL5 DI DM69HL5 DM69HL5 DN Bicyclic heteroaryl amide derivative 2 DM69HL5 MI TT473XN DM69HL5 MN P2X purinoceptor 7 (P2RX7) DM69HL5 MT DTT DM69HL5 MA Antagonist DM69HL5 RN P2X7 receptor antagonists: a patent review (2010-2015).Expert Opin Ther Pat. 2017 Mar;27(3):257-267. DM69HL5 RU https://www.ncbi.nlm.nih.gov/pubmed/27724045 DM0OYCX DI DM0OYCX DM0OYCX DN Bicyclic heteroaryl amide derivative 3 DM0OYCX MI TT473XN DM0OYCX MN P2X purinoceptor 7 (P2RX7) DM0OYCX MT DTT DM0OYCX MA Antagonist DM0OYCX RN P2X7 receptor antagonists: a patent review (2010-2015).Expert Opin Ther Pat. 2017 Mar;27(3):257-267. DM0OYCX RU https://www.ncbi.nlm.nih.gov/pubmed/27724045 DMTBWC9 DI DMTBWC9 DMTBWC9 DN Bicyclic heteroaryl benzamide derivative 1 DMTBWC9 MI TTTDVOJ DMTBWC9 MN Tropomyosin-related kinase A (TrkA) DMTBWC9 MT DTT DMTBWC9 MA Inhibitor DMTBWC9 RN Tropomyosin receptor kinase inhibitors: an updated patent review for 2010-2016 - Part II.Expert Opin Ther Pat. 2017 Jul;27(7):831-849. DMTBWC9 RU https://www.ncbi.nlm.nih.gov/pubmed/28270021 DM5MT4R DI DM5MT4R DM5MT4R DN Bicyclic heteroaryl benzamide derivative 2 DM5MT4R MI TTTDVOJ DM5MT4R MN Tropomyosin-related kinase A (TrkA) DM5MT4R MT DTT DM5MT4R MA Inhibitor DM5MT4R RN Tropomyosin receptor kinase inhibitors: an updated patent review for 2010-2016 - Part II.Expert Opin Ther Pat. 2017 Jul;27(7):831-849. DM5MT4R RU https://www.ncbi.nlm.nih.gov/pubmed/28270021 DM54EV2 DI DM54EV2 DM54EV2 DN Bicyclic heteroaryl benzamide derivative 3 DM54EV2 MI TTTDVOJ DM54EV2 MN Tropomyosin-related kinase A (TrkA) DM54EV2 MT DTT DM54EV2 MA Inhibitor DM54EV2 RN Tropomyosin receptor kinase inhibitors: an updated patent review for 2010-2016 - Part II.Expert Opin Ther Pat. 2017 Jul;27(7):831-849. DM54EV2 RU https://www.ncbi.nlm.nih.gov/pubmed/28270021 DMUBDYG DI DMUBDYG DMUBDYG DN Bicyclic heteroaryl benzamide derivative 4 DMUBDYG MI TTTDVOJ DMUBDYG MN Tropomyosin-related kinase A (TrkA) DMUBDYG MT DTT DMUBDYG MA Inhibitor DMUBDYG RN Tropomyosin receptor kinase inhibitors: an updated patent review for 2010-2016 - Part II.Expert Opin Ther Pat. 2017 Jul;27(7):831-849. DMUBDYG RU https://www.ncbi.nlm.nih.gov/pubmed/28270021 DMFOVPT DI DMFOVPT DMFOVPT DN Bicyclic heteroaryl benzamide derivative 5 DMFOVPT MI TTTDVOJ DMFOVPT MN Tropomyosin-related kinase A (TrkA) DMFOVPT MT DTT DMFOVPT MA Inhibitor DMFOVPT RN Tropomyosin receptor kinase inhibitors: an updated patent review for 2010-2016 - Part II.Expert Opin Ther Pat. 2017 Jul;27(7):831-849. DMFOVPT RU https://www.ncbi.nlm.nih.gov/pubmed/28270021 DMQGYWV DI DMQGYWV DMQGYWV DN Bicyclic heteroaryl benzamide derivative 6 DMQGYWV MI TTTDVOJ DMQGYWV MN Tropomyosin-related kinase A (TrkA) DMQGYWV MT DTT DMQGYWV MA Inhibitor DMQGYWV RN Tropomyosin receptor kinase inhibitors: an updated patent review for 2010-2016 - Part II.Expert Opin Ther Pat. 2017 Jul;27(7):831-849. DMQGYWV RU https://www.ncbi.nlm.nih.gov/pubmed/28270021 DMM1LKF DI DMM1LKF DMM1LKF DN Bicyclic heteroaryl benzamide derivative 7 DMM1LKF MI TTTDVOJ DMM1LKF MN Tropomyosin-related kinase A (TrkA) DMM1LKF MT DTT DMM1LKF MA Inhibitor DMM1LKF RN Tropomyosin receptor kinase inhibitors: an updated patent review for 2010-2016 - Part II.Expert Opin Ther Pat. 2017 Jul;27(7):831-849. DMM1LKF RU https://www.ncbi.nlm.nih.gov/pubmed/28270021 DMVBQJ1 DI DMVBQJ1 DMVBQJ1 DN Bicyclic heteroaryl benzamide derivative 8 DMVBQJ1 MI TTTDVOJ DMVBQJ1 MN Tropomyosin-related kinase A (TrkA) DMVBQJ1 MT DTT DMVBQJ1 MA Inhibitor DMVBQJ1 RN Tropomyosin receptor kinase inhibitors: an updated patent review for 2010-2016 - Part II.Expert Opin Ther Pat. 2017 Jul;27(7):831-849. DMVBQJ1 RU https://www.ncbi.nlm.nih.gov/pubmed/28270021 DMGONY4 DI DMGONY4 DMGONY4 DN Bicyclic heteroaryl benzamide derivative 9 DMGONY4 MI TTTDVOJ DMGONY4 MN Tropomyosin-related kinase A (TrkA) DMGONY4 MT DTT DMGONY4 MA Inhibitor DMGONY4 RN Tropomyosin receptor kinase inhibitors: an updated patent review for 2010-2016 - Part II.Expert Opin Ther Pat. 2017 Jul;27(7):831-849. DMGONY4 RU https://www.ncbi.nlm.nih.gov/pubmed/28270021 DMB5XDM DI DMB5XDM DMB5XDM DN Bicyclic heteroaryl carboxamide analog 1 DMB5XDM MI TTHS256 DMB5XDM MN Metabotropic glutamate receptor 5 (mGluR5) DMB5XDM MT DTT DMB5XDM MA Modulator DMB5XDM RN mGlu5 negative allosteric modulators: a patent review (2013 - 2016).Expert Opin Ther Pat. 2017 Jun;27(6):691-706. DMB5XDM RU https://www.ncbi.nlm.nih.gov/pubmed/28067079 DMKT7MD DI DMKT7MD DMKT7MD DN Bicyclic heteroaryl carboxamide analog 2 DMKT7MD MI TTHS256 DMKT7MD MN Metabotropic glutamate receptor 5 (mGluR5) DMKT7MD MT DTT DMKT7MD MA Modulator DMKT7MD RN mGlu5 negative allosteric modulators: a patent review (2013 - 2016).Expert Opin Ther Pat. 2017 Jun;27(6):691-706. DMKT7MD RU https://www.ncbi.nlm.nih.gov/pubmed/28067079 DM3QMA0 DI DM3QMA0 DM3QMA0 DN Bicyclic heteroaryl carboxamide analog 3 DM3QMA0 MI TTHS256 DM3QMA0 MN Metabotropic glutamate receptor 5 (mGluR5) DM3QMA0 MT DTT DM3QMA0 MA Modulator DM3QMA0 RN mGlu5 negative allosteric modulators: a patent review (2013 - 2016).Expert Opin Ther Pat. 2017 Jun;27(6):691-706. DM3QMA0 RU https://www.ncbi.nlm.nih.gov/pubmed/28067079 DMWTCM8 DI DMWTCM8 DMWTCM8 DN Bicyclic hexapeptide derivative 1 DMWTCM8 MI TT8J1S3 DMWTCM8 MN Smoothened homolog (SMO) DMWTCM8 MT DTT DMWTCM8 MA Inhibitor DMWTCM8 RN Hedgehog inhibitors: a patent review (2013 - present).Expert Opin Ther Pat. 2015 May;25(5):549-65. DMWTCM8 RU https://www.ncbi.nlm.nih.gov/pubmed/25726713 DMJP1IK DI DMJP1IK DMJP1IK DN Bicyclic hexapeptide derivative 2 DMJP1IK MI TT8J1S3 DMJP1IK MN Smoothened homolog (SMO) DMJP1IK MT DTT DMJP1IK MA Inhibitor DMJP1IK RN Hedgehog inhibitors: a patent review (2013 - present).Expert Opin Ther Pat. 2015 May;25(5):549-65. DMJP1IK RU https://www.ncbi.nlm.nih.gov/pubmed/25726713 DMAJ74C DI DMAJ74C DMAJ74C DN Bicyclic pyrimidine derivative 1 DMAJ74C MI TTJOW1I DMAJ74C MN Mannoside acetylglucosaminyltransferase 2 (MGAT2) DMAJ74C MT DTT DMAJ74C MA Inhibitor DMAJ74C RN Acyltransferase inhibitors: a patent review (2010-present).Expert Opin Ther Pat. 2015 Feb;25(2):145-58. DMAJ74C RU https://www.ncbi.nlm.nih.gov/pubmed/25470667 DMJP16K DI DMJP16K DMJP16K DN Bicyclic pyrimidine derivative 2 DMJP16K MI TTDNFMT DMJP16K MN Platelet-activating factor acetylhydrolase (PLA2G7) DMJP16K MT DTT DMJP16K MA Inhibitor DMJP16K RN Inhibitors of phospholipase A2 and their therapeutic potential: an update on patents (2012-2016).Expert Opin Ther Pat. 2017 Feb;27(2):217-225. DMJP16K RU https://www.ncbi.nlm.nih.gov/pubmed/27718763 DMGESCP DI DMGESCP DMGESCP DN Bicyclo-heptan-2-amine derivative 1 DMGESCP MI TT9NXW4 DMGESCP MN Sigma intracellular receptor 2 (TMEM97) DMGESCP MT DTT DMGESCP MA Ligand DMGESCP RN Are sigma modulators an effective opportunity for cancer treatment A patent overview (1996-2016).Expert Opin Ther Pat. 2017 May;27(5):565-578. DMGESCP RU https://www.ncbi.nlm.nih.gov/pubmed/28051882 DM9WUH5 DI DM9WUH5 DM9WUH5 DN Bicyclo-heptan-2-amine derivative 2 DM9WUH5 MI TT9NXW4 DM9WUH5 MN Sigma intracellular receptor 2 (TMEM97) DM9WUH5 MT DTT DM9WUH5 MA Ligand DM9WUH5 RN Are sigma modulators an effective opportunity for cancer treatment A patent overview (1996-2016).Expert Opin Ther Pat. 2017 May;27(5):565-578. DM9WUH5 RU https://www.ncbi.nlm.nih.gov/pubmed/28051882 DM8ZRXE DI DM8ZRXE DM8ZRXE DN Bicyclo-heptan-2-amine derivative 3 DM8ZRXE MI TT9NXW4 DM8ZRXE MN Sigma intracellular receptor 2 (TMEM97) DM8ZRXE MT DTT DM8ZRXE MA Ligand DM8ZRXE RN Are sigma modulators an effective opportunity for cancer treatment A patent overview (1996-2016).Expert Opin Ther Pat. 2017 May;27(5):565-578. DM8ZRXE RU https://www.ncbi.nlm.nih.gov/pubmed/28051882 DMPRIS0 DI DMPRIS0 DMPRIS0 DN Bicyclo-heptan-2-amine derivative 4 DMPRIS0 MI TT9NXW4 DMPRIS0 MN Sigma intracellular receptor 2 (TMEM97) DMPRIS0 MT DTT DMPRIS0 MA Ligand DMPRIS0 RN Are sigma modulators an effective opportunity for cancer treatment A patent overview (1996-2016).Expert Opin Ther Pat. 2017 May;27(5):565-578. DMPRIS0 RU https://www.ncbi.nlm.nih.gov/pubmed/28051882 DMB08D3 DI DMB08D3 DMB08D3 DN Bidentate ligands of Markush derivative 1 DMB08D3 MI TTK0FEA DMB08D3 MN Leucine-rich repeat kinase 2 (LRRK2) DMB08D3 MT DTT DMB08D3 MA Inhibitor DMB08D3 RN Leucine-rich repeat kinase 2 inhibitors: a patent review (2014-2016).Expert Opin Ther Pat. 2017 Jun;27(6):667-676. DMB08D3 RU https://www.ncbi.nlm.nih.gov/pubmed/28117607 DMB08D3 DI DMB08D3 DMB08D3 DN Bidentate ligands of Markush derivative 1 DMB08D3 MI TTVOE6D DMB08D3 MN Mitogen-activated protein kinase (MAPK) DMB08D3 MT DTT DMB08D3 MA Inhibitor DMB08D3 RN Leucine-rich repeat kinase 2 inhibitors: a patent review (2014-2016).Expert Opin Ther Pat. 2017 Jun;27(6):667-676. DMB08D3 RU https://www.ncbi.nlm.nih.gov/pubmed/28117607 DM2QNMC DI DM2QNMC DM2QNMC DN Bidentate ligands of Markush derivative 2 DM2QNMC MI TTK0FEA DM2QNMC MN Leucine-rich repeat kinase 2 (LRRK2) DM2QNMC MT DTT DM2QNMC MA Inhibitor DM2QNMC RN Leucine-rich repeat kinase 2 inhibitors: a patent review (2014-2016).Expert Opin Ther Pat. 2017 Jun;27(6):667-676. DM2QNMC RU https://www.ncbi.nlm.nih.gov/pubmed/28117607 DM2QNMC DI DM2QNMC DM2QNMC DN Bidentate ligands of Markush derivative 2 DM2QNMC MI TTVOE6D DM2QNMC MN Mitogen-activated protein kinase (MAPK) DM2QNMC MT DTT DM2QNMC MA Inhibitor DM2QNMC RN Leucine-rich repeat kinase 2 inhibitors: a patent review (2014-2016).Expert Opin Ther Pat. 2017 Jun;27(6):667-676. DM2QNMC RU https://www.ncbi.nlm.nih.gov/pubmed/28117607 DMPWKAH DI DMPWKAH DMPWKAH DN Bidentate pyrazolopyrimidine acetamide analog 1 DMPWKAH MI TTPTXIN DMPWKAH MN Translocator protein (TSPO) DMPWKAH MT DTT DMPWKAH MA Ligand DMPWKAH RN Translocator protein (TSPO) ligands for the diagnosis or treatment of neurodegenerative diseases: a patent review (2010-2015; part 1).Expert Opin Ther Pat. 2016 Nov;26(11):1325-1351. DMPWKAH RU https://www.ncbi.nlm.nih.gov/pubmed/27607364 DM6SPTJ DI DM6SPTJ DM6SPTJ DN Bidentate pyrazolopyrimidine acetamide analog 2 DM6SPTJ MI TTPTXIN DM6SPTJ MN Translocator protein (TSPO) DM6SPTJ MT DTT DM6SPTJ MA Ligand DM6SPTJ RN Translocator protein (TSPO) ligands for the diagnosis or treatment of neurodegenerative diseases: a patent review (2010-2015; part 1).Expert Opin Ther Pat. 2016 Nov;26(11):1325-1351. DM6SPTJ RU https://www.ncbi.nlm.nih.gov/pubmed/27607364 DMC7UHT DI DMC7UHT DMC7UHT DN Bidentate pyrazolopyrimidine acetamide analog 3 DMC7UHT MI TTPTXIN DMC7UHT MN Translocator protein (TSPO) DMC7UHT MT DTT DMC7UHT MA Ligand DMC7UHT RN Translocator protein (TSPO) ligands for the diagnosis or treatment of neurodegenerative diseases: a patent review (2010-2015; part 1).Expert Opin Ther Pat. 2016 Nov;26(11):1325-1351. DMC7UHT RU https://www.ncbi.nlm.nih.gov/pubmed/27607364 DMKZLCQ DI DMKZLCQ DMKZLCQ DN Bidentate pyrazolopyrimidine acetamide analog 4 DMKZLCQ MI TTPTXIN DMKZLCQ MN Translocator protein (TSPO) DMKZLCQ MT DTT DMKZLCQ MA Ligand DMKZLCQ RN Translocator protein (TSPO) ligands for the diagnosis or treatment of neurodegenerative diseases: a patent review (2010-2015; part 1).Expert Opin Ther Pat. 2016 Nov;26(11):1325-1351. DMKZLCQ RU https://www.ncbi.nlm.nih.gov/pubmed/27607364 DM5WN0U DI DM5WN0U DM5WN0U DN Binuclear gold(I) compound 1 DM5WN0U MI TTR7UJ3 DM5WN0U MN Cytoplasmic thioredoxin reductase (TXNRD1) DM5WN0U MT DTT DM5WN0U MA Inhibitor DM5WN0U RN Thioredoxin reductase inhibitors: a patent review.Expert Opin Ther Pat. 2017 May;27(5):547-556. DM5WN0U RU https://www.ncbi.nlm.nih.gov/pubmed/27977313 DM5WAGC DI DM5WAGC DM5WAGC DN Binuclear gold(I) compound 2 DM5WAGC MI TTR7UJ3 DM5WAGC MN Cytoplasmic thioredoxin reductase (TXNRD1) DM5WAGC MT DTT DM5WAGC MA Inhibitor DM5WAGC RN Thioredoxin reductase inhibitors: a patent review.Expert Opin Ther Pat. 2017 May;27(5):547-556. DM5WAGC RU https://www.ncbi.nlm.nih.gov/pubmed/27977313 DM94TKW DI DM94TKW DM94TKW DN Binuclear gold(I) compound 3 DM94TKW MI TTR7UJ3 DM94TKW MN Cytoplasmic thioredoxin reductase (TXNRD1) DM94TKW MT DTT DM94TKW MA Inhibitor DM94TKW RN Thioredoxin reductase inhibitors: a patent review.Expert Opin Ther Pat. 2017 May;27(5):547-556. DM94TKW RU https://www.ncbi.nlm.nih.gov/pubmed/27977313 DM1VYZ9 DI DM1VYZ9 DM1VYZ9 DN Biphenyl 1,2-diamine derivative 1 DM1VYZ9 MI TTZJYKH DM1VYZ9 MN Indoleamine 2,3-dioxygenase 1 (IDO1) DM1VYZ9 MT DTT DM1VYZ9 MA Modulator DM1VYZ9 RN A patent review of IDO1 inhibitors for cancer.Expert Opin Ther Pat. 2018 Apr;28(4):317-330. DM1VYZ9 RU https://www.ncbi.nlm.nih.gov/pubmed/29473428 DM6803W DI DM6803W DM6803W DN Biphenyl carboxamidopropanoic acid derivative 1 DM6803W MI TT9O6WS DM6803W MN Glucagon receptor (GCGR) DM6803W MT DTT DM6803W MA Antagonist DM6803W RN Small molecule glucagon receptor antagonists: a patent review (2011 - 2014).Expert Opin Ther Pat. 2015 Jul;25(7):819-30. DM6803W RU https://www.ncbi.nlm.nih.gov/pubmed/25828189 DMQF2XN DI DMQF2XN DMQF2XN DN Biphenyl carboxamidopropanoic acid derivative 2 DMQF2XN MI TT9O6WS DMQF2XN MN Glucagon receptor (GCGR) DMQF2XN MT DTT DMQF2XN MA Antagonist DMQF2XN RN Small molecule glucagon receptor antagonists: a patent review (2011 - 2014).Expert Opin Ther Pat. 2015 Jul;25(7):819-30. DMQF2XN RU https://www.ncbi.nlm.nih.gov/pubmed/25828189 DMLOVMP DI DMLOVMP DMLOVMP DN Biphenyl carboxamidopropanoic acid derivative 3 DMLOVMP MI TT9O6WS DMLOVMP MN Glucagon receptor (GCGR) DMLOVMP MT DTT DMLOVMP MA Antagonist DMLOVMP RN Small molecule glucagon receptor antagonists: a patent review (2011 - 2014).Expert Opin Ther Pat. 2015 Jul;25(7):819-30. DMLOVMP RU https://www.ncbi.nlm.nih.gov/pubmed/25828189 DM715E8 DI DM715E8 DM715E8 DN Biphenyl carboxamidopropanoic acid derivative 4 DM715E8 MI TT9O6WS DM715E8 MN Glucagon receptor (GCGR) DM715E8 MT DTT DM715E8 MA Antagonist DM715E8 RN Small molecule glucagon receptor antagonists: a patent review (2011 - 2014).Expert Opin Ther Pat. 2015 Jul;25(7):819-30. DM715E8 RU https://www.ncbi.nlm.nih.gov/pubmed/25828189 DMPWFJN DI DMPWFJN DMPWFJN DN Biphenyl carboxylic acid derivative 1 DMPWFJN MI TTL53M6 DMPWFJN MN Induced myeloid leukemia cell differentiation protein Mcl-1 (MCL1) DMPWFJN MT DTT DMPWFJN MA Inhibitor DMPWFJN RN Mcl-1 inhibitors: a patent review.Expert Opin Ther Pat. 2017 Feb;27(2):163-178. DMPWFJN RU https://www.ncbi.nlm.nih.gov/pubmed/27744724 DM6TXF4 DI DM6TXF4 DM6TXF4 DN Biphenyl carboxylic acid derivative 2 DM6TXF4 MI TTL53M6 DM6TXF4 MN Induced myeloid leukemia cell differentiation protein Mcl-1 (MCL1) DM6TXF4 MT DTT DM6TXF4 MA Inhibitor DM6TXF4 RN Mcl-1 inhibitors: a patent review.Expert Opin Ther Pat. 2017 Feb;27(2):163-178. DM6TXF4 RU https://www.ncbi.nlm.nih.gov/pubmed/27744724 DMG4WQB DI DMG4WQB DMG4WQB DN Biphenyl derivative 1 DMG4WQB MI TTZJYKH DMG4WQB MN Indoleamine 2,3-dioxygenase 1 (IDO1) DMG4WQB MT DTT DMG4WQB MA Inhibitor DMG4WQB RN A patent review of IDO1 inhibitors for cancer.Expert Opin Ther Pat. 2018 Apr;28(4):317-330. DMG4WQB RU https://www.ncbi.nlm.nih.gov/pubmed/29473428 DMJ4TZX DI DMJ4TZX DMJ4TZX DN Biphenyl derivative 2 DMJ4TZX MI TTZJYKH DMJ4TZX MN Indoleamine 2,3-dioxygenase 1 (IDO1) DMJ4TZX MT DTT DMJ4TZX MA Inhibitor DMJ4TZX RN A patent review of IDO1 inhibitors for cancer.Expert Opin Ther Pat. 2018 Apr;28(4):317-330. DMJ4TZX RU https://www.ncbi.nlm.nih.gov/pubmed/29473428 DMM3SWV DI DMM3SWV DMM3SWV DN Biphenyl derivative 3 DMM3SWV MI TTZJYKH DMM3SWV MN Indoleamine 2,3-dioxygenase 1 (IDO1) DMM3SWV MT DTT DMM3SWV MA Inhibitor DMM3SWV RN A patent review of IDO1 inhibitors for cancer.Expert Opin Ther Pat. 2018 Apr;28(4):317-330. DMM3SWV RU https://www.ncbi.nlm.nih.gov/pubmed/29473428 DMIPVYW DI DMIPVYW DMIPVYW DN Biphenyl derivative 4 DMIPVYW MI TT9JNIC DMIPVYW MN Histamine H3 receptor (H3R) DMIPVYW MT DTT DMIPVYW RN Progress in the development of histamine H3 receptor antagonists/inverse agonists: a patent review (2013-2017).Expert Opin Ther Pat. 2018 Mar;28(3):175-196. DMIPVYW RU https://www.ncbi.nlm.nih.gov/pubmed/29334795 DMS5UFX DI DMS5UFX DMS5UFX DN Biphenyl mannoside derivative 1 DMS5UFX MI TTTCRU2 DMS5UFX MN Bacterial Fimbrin D-mannose adhesin (Bact FimH) DMS5UFX MT DTT DMS5UFX MA Antagonist DMS5UFX RN Mannose-derived FimH antagonists: a promising anti-virulence therapeutic strategy for urinary tract infections and Crohn's disease.Expert Opin Ther Pat. 2016;26(2):175-97. DMS5UFX RU https://www.ncbi.nlm.nih.gov/pubmed/26651364 DMITLPW DI DMITLPW DMITLPW DN Biphenyl mannoside derivative 10 DMITLPW MI TTTCRU2 DMITLPW MN Bacterial Fimbrin D-mannose adhesin (Bact FimH) DMITLPW MT DTT DMITLPW MA Antagonist DMITLPW RN Mannose-derived FimH antagonists: a promising anti-virulence therapeutic strategy for urinary tract infections and Crohn's disease.Expert Opin Ther Pat. 2016;26(2):175-97. DMITLPW RU https://www.ncbi.nlm.nih.gov/pubmed/26651364 DMZF5XI DI DMZF5XI DMZF5XI DN Biphenyl mannoside derivative 11 DMZF5XI MI TTTCRU2 DMZF5XI MN Bacterial Fimbrin D-mannose adhesin (Bact FimH) DMZF5XI MT DTT DMZF5XI MA Antagonist DMZF5XI RN Mannose-derived FimH antagonists: a promising anti-virulence therapeutic strategy for urinary tract infections and Crohn's disease.Expert Opin Ther Pat. 2016;26(2):175-97. DMZF5XI RU https://www.ncbi.nlm.nih.gov/pubmed/26651364 DMU0YST DI DMU0YST DMU0YST DN Biphenyl mannoside derivative 12 DMU0YST MI TTTCRU2 DMU0YST MN Bacterial Fimbrin D-mannose adhesin (Bact FimH) DMU0YST MT DTT DMU0YST MA Antagonist DMU0YST RN Mannose-derived FimH antagonists: a promising anti-virulence therapeutic strategy for urinary tract infections and Crohn's disease.Expert Opin Ther Pat. 2016;26(2):175-97. DMU0YST RU https://www.ncbi.nlm.nih.gov/pubmed/26651364 DM83LTH DI DM83LTH DM83LTH DN Biphenyl mannoside derivative 13 DM83LTH MI TTTCRU2 DM83LTH MN Bacterial Fimbrin D-mannose adhesin (Bact FimH) DM83LTH MT DTT DM83LTH MA Antagonist DM83LTH RN Mannose-derived FimH antagonists: a promising anti-virulence therapeutic strategy for urinary tract infections and Crohn's disease.Expert Opin Ther Pat. 2016;26(2):175-97. DM83LTH RU https://www.ncbi.nlm.nih.gov/pubmed/26651364 DMMRTWG DI DMMRTWG DMMRTWG DN Biphenyl mannoside derivative 14 DMMRTWG MI TTTCRU2 DMMRTWG MN Bacterial Fimbrin D-mannose adhesin (Bact FimH) DMMRTWG MT DTT DMMRTWG MA Antagonist DMMRTWG RN Mannose-derived FimH antagonists: a promising anti-virulence therapeutic strategy for urinary tract infections and Crohn's disease.Expert Opin Ther Pat. 2016;26(2):175-97. DMMRTWG RU https://www.ncbi.nlm.nih.gov/pubmed/26651364 DM97BIQ DI DM97BIQ DM97BIQ DN Biphenyl mannoside derivative 15 DM97BIQ MI TTTCRU2 DM97BIQ MN Bacterial Fimbrin D-mannose adhesin (Bact FimH) DM97BIQ MT DTT DM97BIQ MA Antagonist DM97BIQ RN Mannose-derived FimH antagonists: a promising anti-virulence therapeutic strategy for urinary tract infections and Crohn's disease.Expert Opin Ther Pat. 2016;26(2):175-97. DM97BIQ RU https://www.ncbi.nlm.nih.gov/pubmed/26651364 DMECZVG DI DMECZVG DMECZVG DN Biphenyl mannoside derivative 16 DMECZVG MI TTTCRU2 DMECZVG MN Bacterial Fimbrin D-mannose adhesin (Bact FimH) DMECZVG MT DTT DMECZVG MA Antagonist DMECZVG RN Mannose-derived FimH antagonists: a promising anti-virulence therapeutic strategy for urinary tract infections and Crohn's disease.Expert Opin Ther Pat. 2016;26(2):175-97. DMECZVG RU https://www.ncbi.nlm.nih.gov/pubmed/26651364 DM7L8T5 DI DM7L8T5 DM7L8T5 DN Biphenyl mannoside derivative 17 DM7L8T5 MI TTTCRU2 DM7L8T5 MN Bacterial Fimbrin D-mannose adhesin (Bact FimH) DM7L8T5 MT DTT DM7L8T5 MA Antagonist DM7L8T5 RN Mannose-derived FimH antagonists: a promising anti-virulence therapeutic strategy for urinary tract infections and Crohn's disease.Expert Opin Ther Pat. 2016;26(2):175-97. DM7L8T5 RU https://www.ncbi.nlm.nih.gov/pubmed/26651364 DM2GZ5Y DI DM2GZ5Y DM2GZ5Y DN Biphenyl mannoside derivative 18 DM2GZ5Y MI TTTCRU2 DM2GZ5Y MN Bacterial Fimbrin D-mannose adhesin (Bact FimH) DM2GZ5Y MT DTT DM2GZ5Y MA Antagonist DM2GZ5Y RN Mannose-derived FimH antagonists: a promising anti-virulence therapeutic strategy for urinary tract infections and Crohn's disease.Expert Opin Ther Pat. 2016;26(2):175-97. DM2GZ5Y RU https://www.ncbi.nlm.nih.gov/pubmed/26651364 DMGA0R6 DI DMGA0R6 DMGA0R6 DN Biphenyl mannoside derivative 19 DMGA0R6 MI TTTCRU2 DMGA0R6 MN Bacterial Fimbrin D-mannose adhesin (Bact FimH) DMGA0R6 MT DTT DMGA0R6 MA Antagonist DMGA0R6 RN Mannose-derived FimH antagonists: a promising anti-virulence therapeutic strategy for urinary tract infections and Crohn's disease.Expert Opin Ther Pat. 2016;26(2):175-97. DMGA0R6 RU https://www.ncbi.nlm.nih.gov/pubmed/26651364 DMQB4DR DI DMQB4DR DMQB4DR DN Biphenyl mannoside derivative 2 DMQB4DR MI TTTCRU2 DMQB4DR MN Bacterial Fimbrin D-mannose adhesin (Bact FimH) DMQB4DR MT DTT DMQB4DR MA Antagonist DMQB4DR RN Mannose-derived FimH antagonists: a promising anti-virulence therapeutic strategy for urinary tract infections and Crohn's disease.Expert Opin Ther Pat. 2016;26(2):175-97. DMQB4DR RU https://www.ncbi.nlm.nih.gov/pubmed/26651364 DMDIYJ1 DI DMDIYJ1 DMDIYJ1 DN Biphenyl mannoside derivative 20 DMDIYJ1 MI TTTCRU2 DMDIYJ1 MN Bacterial Fimbrin D-mannose adhesin (Bact FimH) DMDIYJ1 MT DTT DMDIYJ1 MA Antagonist DMDIYJ1 RN Mannose-derived FimH antagonists: a promising anti-virulence therapeutic strategy for urinary tract infections and Crohn's disease.Expert Opin Ther Pat. 2016;26(2):175-97. DMDIYJ1 RU https://www.ncbi.nlm.nih.gov/pubmed/26651364 DMTR6BX DI DMTR6BX DMTR6BX DN Biphenyl mannoside derivative 21 DMTR6BX MI TTTCRU2 DMTR6BX MN Bacterial Fimbrin D-mannose adhesin (Bact FimH) DMTR6BX MT DTT DMTR6BX MA Antagonist DMTR6BX RN Mannose-derived FimH antagonists: a promising anti-virulence therapeutic strategy for urinary tract infections and Crohn's disease.Expert Opin Ther Pat. 2016;26(2):175-97. DMTR6BX RU https://www.ncbi.nlm.nih.gov/pubmed/26651364 DMQGFKY DI DMQGFKY DMQGFKY DN Biphenyl mannoside derivative 22 DMQGFKY MI TTTCRU2 DMQGFKY MN Bacterial Fimbrin D-mannose adhesin (Bact FimH) DMQGFKY MT DTT DMQGFKY MA Antagonist DMQGFKY RN Mannose-derived FimH antagonists: a promising anti-virulence therapeutic strategy for urinary tract infections and Crohn's disease.Expert Opin Ther Pat. 2016;26(2):175-97. DMQGFKY RU https://www.ncbi.nlm.nih.gov/pubmed/26651364 DMC8OVU DI DMC8OVU DMC8OVU DN Biphenyl mannoside derivative 23 DMC8OVU MI TTTCRU2 DMC8OVU MN Bacterial Fimbrin D-mannose adhesin (Bact FimH) DMC8OVU MT DTT DMC8OVU MA Antagonist DMC8OVU RN Mannose-derived FimH antagonists: a promising anti-virulence therapeutic strategy for urinary tract infections and Crohn's disease.Expert Opin Ther Pat. 2016;26(2):175-97. DMC8OVU RU https://www.ncbi.nlm.nih.gov/pubmed/26651364 DMLUZ3K DI DMLUZ3K DMLUZ3K DN Biphenyl mannoside derivative 24 DMLUZ3K MI TTTCRU2 DMLUZ3K MN Bacterial Fimbrin D-mannose adhesin (Bact FimH) DMLUZ3K MT DTT DMLUZ3K MA Antagonist DMLUZ3K RN Mannose-derived FimH antagonists: a promising anti-virulence therapeutic strategy for urinary tract infections and Crohn's disease.Expert Opin Ther Pat. 2016;26(2):175-97. DMLUZ3K RU https://www.ncbi.nlm.nih.gov/pubmed/26651364 DMBWQ8L DI DMBWQ8L DMBWQ8L DN Biphenyl mannoside derivative 25 DMBWQ8L MI TTTCRU2 DMBWQ8L MN Bacterial Fimbrin D-mannose adhesin (Bact FimH) DMBWQ8L MT DTT DMBWQ8L MA Antagonist DMBWQ8L RN Mannose-derived FimH antagonists: a promising anti-virulence therapeutic strategy for urinary tract infections and Crohn's disease.Expert Opin Ther Pat. 2016;26(2):175-97. DMBWQ8L RU https://www.ncbi.nlm.nih.gov/pubmed/26651364 DM5Q4T2 DI DM5Q4T2 DM5Q4T2 DN Biphenyl mannoside derivative 26 DM5Q4T2 MI TTTCRU2 DM5Q4T2 MN Bacterial Fimbrin D-mannose adhesin (Bact FimH) DM5Q4T2 MT DTT DM5Q4T2 MA Antagonist DM5Q4T2 RN Mannose-derived FimH antagonists: a promising anti-virulence therapeutic strategy for urinary tract infections and Crohn's disease.Expert Opin Ther Pat. 2016;26(2):175-97. DM5Q4T2 RU https://www.ncbi.nlm.nih.gov/pubmed/26651364 DMWQ6FJ DI DMWQ6FJ DMWQ6FJ DN Biphenyl mannoside derivative 27 DMWQ6FJ MI TTTCRU2 DMWQ6FJ MN Bacterial Fimbrin D-mannose adhesin (Bact FimH) DMWQ6FJ MT DTT DMWQ6FJ MA Antagonist DMWQ6FJ RN Mannose-derived FimH antagonists: a promising anti-virulence therapeutic strategy for urinary tract infections and Crohn's disease.Expert Opin Ther Pat. 2016;26(2):175-97. DMWQ6FJ RU https://www.ncbi.nlm.nih.gov/pubmed/26651364 DMMOTWK DI DMMOTWK DMMOTWK DN Biphenyl mannoside derivative 28 DMMOTWK MI TTTCRU2 DMMOTWK MN Bacterial Fimbrin D-mannose adhesin (Bact FimH) DMMOTWK MT DTT DMMOTWK MA Antagonist DMMOTWK RN Mannose-derived FimH antagonists: a promising anti-virulence therapeutic strategy for urinary tract infections and Crohn's disease.Expert Opin Ther Pat. 2016;26(2):175-97. DMMOTWK RU https://www.ncbi.nlm.nih.gov/pubmed/26651364 DM9H0Q3 DI DM9H0Q3 DM9H0Q3 DN Biphenyl mannoside derivative 29 DM9H0Q3 MI TTTCRU2 DM9H0Q3 MN Bacterial Fimbrin D-mannose adhesin (Bact FimH) DM9H0Q3 MT DTT DM9H0Q3 MA Antagonist DM9H0Q3 RN Mannose-derived FimH antagonists: a promising anti-virulence therapeutic strategy for urinary tract infections and Crohn's disease.Expert Opin Ther Pat. 2016;26(2):175-97. DM9H0Q3 RU https://www.ncbi.nlm.nih.gov/pubmed/26651364 DMOKJEP DI DMOKJEP DMOKJEP DN Biphenyl mannoside derivative 3 DMOKJEP MI TTTCRU2 DMOKJEP MN Bacterial Fimbrin D-mannose adhesin (Bact FimH) DMOKJEP MT DTT DMOKJEP MA Antagonist DMOKJEP RN Mannose-derived FimH antagonists: a promising anti-virulence therapeutic strategy for urinary tract infections and Crohn's disease.Expert Opin Ther Pat. 2016;26(2):175-97. DMOKJEP RU https://www.ncbi.nlm.nih.gov/pubmed/26651364 DM81RIY DI DM81RIY DM81RIY DN Biphenyl mannoside derivative 30 DM81RIY MI TTTCRU2 DM81RIY MN Bacterial Fimbrin D-mannose adhesin (Bact FimH) DM81RIY MT DTT DM81RIY MA Antagonist DM81RIY RN Mannose-derived FimH antagonists: a promising anti-virulence therapeutic strategy for urinary tract infections and Crohn's disease.Expert Opin Ther Pat. 2016;26(2):175-97. DM81RIY RU https://www.ncbi.nlm.nih.gov/pubmed/26651364 DM0VR23 DI DM0VR23 DM0VR23 DN Biphenyl mannoside derivative 4 DM0VR23 MI TTTCRU2 DM0VR23 MN Bacterial Fimbrin D-mannose adhesin (Bact FimH) DM0VR23 MT DTT DM0VR23 MA Antagonist DM0VR23 RN Mannose-derived FimH antagonists: a promising anti-virulence therapeutic strategy for urinary tract infections and Crohn's disease.Expert Opin Ther Pat. 2016;26(2):175-97. DM0VR23 RU https://www.ncbi.nlm.nih.gov/pubmed/26651364 DMOS03R DI DMOS03R DMOS03R DN Biphenyl mannoside derivative 5 DMOS03R MI TTTCRU2 DMOS03R MN Bacterial Fimbrin D-mannose adhesin (Bact FimH) DMOS03R MT DTT DMOS03R MA Antagonist DMOS03R RN Mannose-derived FimH antagonists: a promising anti-virulence therapeutic strategy for urinary tract infections and Crohn's disease.Expert Opin Ther Pat. 2016;26(2):175-97. DMOS03R RU https://www.ncbi.nlm.nih.gov/pubmed/26651364 DM93VEB DI DM93VEB DM93VEB DN Biphenyl mannoside derivative 6 DM93VEB MI TTTCRU2 DM93VEB MN Bacterial Fimbrin D-mannose adhesin (Bact FimH) DM93VEB MT DTT DM93VEB MA Antagonist DM93VEB RN Mannose-derived FimH antagonists: a promising anti-virulence therapeutic strategy for urinary tract infections and Crohn's disease.Expert Opin Ther Pat. 2016;26(2):175-97. DM93VEB RU https://www.ncbi.nlm.nih.gov/pubmed/26651364 DM46NRV DI DM46NRV DM46NRV DN Biphenyl mannoside derivative 7 DM46NRV MI TTTCRU2 DM46NRV MN Bacterial Fimbrin D-mannose adhesin (Bact FimH) DM46NRV MT DTT DM46NRV MA Antagonist DM46NRV RN Mannose-derived FimH antagonists: a promising anti-virulence therapeutic strategy for urinary tract infections and Crohn's disease.Expert Opin Ther Pat. 2016;26(2):175-97. DM46NRV RU https://www.ncbi.nlm.nih.gov/pubmed/26651364 DMZCWM5 DI DMZCWM5 DMZCWM5 DN Biphenyl mannoside derivative 8 DMZCWM5 MI TTTCRU2 DMZCWM5 MN Bacterial Fimbrin D-mannose adhesin (Bact FimH) DMZCWM5 MT DTT DMZCWM5 MA Antagonist DMZCWM5 RN Mannose-derived FimH antagonists: a promising anti-virulence therapeutic strategy for urinary tract infections and Crohn's disease.Expert Opin Ther Pat. 2016;26(2):175-97. DMZCWM5 RU https://www.ncbi.nlm.nih.gov/pubmed/26651364 DMP52HJ DI DMP52HJ DMP52HJ DN Biphenyl mannoside derivative 9 DMP52HJ MI TTTCRU2 DMP52HJ MN Bacterial Fimbrin D-mannose adhesin (Bact FimH) DMP52HJ MT DTT DMP52HJ MA Antagonist DMP52HJ RN Mannose-derived FimH antagonists: a promising anti-virulence therapeutic strategy for urinary tract infections and Crohn's disease.Expert Opin Ther Pat. 2016;26(2):175-97. DMP52HJ RU https://www.ncbi.nlm.nih.gov/pubmed/26651364 DM6KGUB DI DM6KGUB DM6KGUB DN Bipyrazole derivative 1 DM6KGUB MI TT6DM01 DM6KGUB MN Janus kinase 1 (JAK-1) DM6KGUB MT DTT DM6KGUB MA Inhibitor DM6KGUB RN Inhibitors of JAK-family kinases: an update on the patent literature 2013-2015, part 1.Expert Opin Ther Pat. 2017 Feb;27(2):127-143. DM6KGUB RU https://www.ncbi.nlm.nih.gov/pubmed/27774824 DMPUXL3 DI DMPUXL3 DMPUXL3 DN Bipyridine derivative 1 DMPUXL3 MI TT1LVF2 DMPUXL3 MN Cyclin-dependent kinase 9 (CDK9) DMPUXL3 MT DTT DMPUXL3 MA Inhibitor DMPUXL3 RN Cyclin-dependent kinase inhibitors for cancer therapy: a patent review (2009 - 2014).Expert Opin Ther Pat. 2015;25(9):953-70. DMPUXL3 RU https://www.ncbi.nlm.nih.gov/pubmed/26161698 DMQL34C DI DMQL34C DMQL34C DN Bis-aminopyrimidine derivative 1 DMQL34C MI TT6DM01 DMQL34C MN Janus kinase 1 (JAK-1) DMQL34C MT DTT DMQL34C MA Inhibitor DMQL34C RN Inhibitors of JAK-family kinases: an update on the patent literature 2013-2015, part 1.Expert Opin Ther Pat. 2017 Feb;27(2):127-143. DMQL34C RU https://www.ncbi.nlm.nih.gov/pubmed/27774824 DMQL34C DI DMQL34C DMQL34C DN Bis-aminopyrimidine derivative 1 DMQL34C MI TTRMX3V DMQL34C MN Janus kinase 2 (JAK-2) DMQL34C MT DTT DMQL34C MA Inhibitor DMQL34C RN Inhibitors of JAK-family kinases: an update on the patent literature 2013-2015, part 1.Expert Opin Ther Pat. 2017 Feb;27(2):127-143. DMQL34C RU https://www.ncbi.nlm.nih.gov/pubmed/27774824 DMQL34C DI DMQL34C DMQL34C DN Bis-aminopyrimidine derivative 1 DMQL34C MI TTT7PJU DMQL34C MN Janus kinase 3 (JAK-3) DMQL34C MT DTT DMQL34C MA Inhibitor DMQL34C RN Inhibitors of JAK-family kinases: an update on the patent literature 2013-2015, part 1.Expert Opin Ther Pat. 2017 Feb;27(2):127-143. DMQL34C RU https://www.ncbi.nlm.nih.gov/pubmed/27774824 DMQL34C DI DMQL34C DMQL34C DN Bis-aminopyrimidine derivative 1 DMQL34C MI TTBYWP2 DMQL34C MN TYK2 tyrosine kinase (TYK2) DMQL34C MT DTT DMQL34C MA Inhibitor DMQL34C RN Inhibitors of JAK-family kinases: an update on the patent literature 2013-2015, part 1.Expert Opin Ther Pat. 2017 Feb;27(2):127-143. DMQL34C RU https://www.ncbi.nlm.nih.gov/pubmed/27774824 DMJXNO1 DI DMJXNO1 DMJXNO1 DN Bis-aminopyrimidine derivative 2 DMJXNO1 MI TT6DM01 DMJXNO1 MN Janus kinase 1 (JAK-1) DMJXNO1 MT DTT DMJXNO1 MA Inhibitor DMJXNO1 RN Inhibitors of JAK-family kinases: an update on the patent literature 2013-2015, part 1.Expert Opin Ther Pat. 2017 Feb;27(2):127-143. DMJXNO1 RU https://www.ncbi.nlm.nih.gov/pubmed/27774824 DMJXNO1 DI DMJXNO1 DMJXNO1 DN Bis-aminopyrimidine derivative 2 DMJXNO1 MI TTRMX3V DMJXNO1 MN Janus kinase 2 (JAK-2) DMJXNO1 MT DTT DMJXNO1 MA Inhibitor DMJXNO1 RN Inhibitors of JAK-family kinases: an update on the patent literature 2013-2015, part 1.Expert Opin Ther Pat. 2017 Feb;27(2):127-143. DMJXNO1 RU https://www.ncbi.nlm.nih.gov/pubmed/27774824 DMJXNO1 DI DMJXNO1 DMJXNO1 DN Bis-aminopyrimidine derivative 2 DMJXNO1 MI TTT7PJU DMJXNO1 MN Janus kinase 3 (JAK-3) DMJXNO1 MT DTT DMJXNO1 MA Inhibitor DMJXNO1 RN Inhibitors of JAK-family kinases: an update on the patent literature 2013-2015, part 1.Expert Opin Ther Pat. 2017 Feb;27(2):127-143. DMJXNO1 RU https://www.ncbi.nlm.nih.gov/pubmed/27774824 DMJXNO1 DI DMJXNO1 DMJXNO1 DN Bis-aminopyrimidine derivative 2 DMJXNO1 MI TTBYWP2 DMJXNO1 MN TYK2 tyrosine kinase (TYK2) DMJXNO1 MT DTT DMJXNO1 MA Inhibitor DMJXNO1 RN Inhibitors of JAK-family kinases: an update on the patent literature 2013-2015, part 1.Expert Opin Ther Pat. 2017 Feb;27(2):127-143. DMJXNO1 RU https://www.ncbi.nlm.nih.gov/pubmed/27774824 DMUNSYX DI DMUNSYX DMUNSYX DN Bis-aminopyrimidine derivative 3 DMUNSYX MI TT6DM01 DMUNSYX MN Janus kinase 1 (JAK-1) DMUNSYX MT DTT DMUNSYX MA Inhibitor DMUNSYX RN Inhibitors of JAK-family kinases: an update on the patent literature 2013-2015, part 1.Expert Opin Ther Pat. 2017 Feb;27(2):127-143. DMUNSYX RU https://www.ncbi.nlm.nih.gov/pubmed/27774824 DMUNSYX DI DMUNSYX DMUNSYX DN Bis-aminopyrimidine derivative 3 DMUNSYX MI TTRMX3V DMUNSYX MN Janus kinase 2 (JAK-2) DMUNSYX MT DTT DMUNSYX MA Inhibitor DMUNSYX RN Inhibitors of JAK-family kinases: an update on the patent literature 2013-2015, part 1.Expert Opin Ther Pat. 2017 Feb;27(2):127-143. DMUNSYX RU https://www.ncbi.nlm.nih.gov/pubmed/27774824 DMUNSYX DI DMUNSYX DMUNSYX DN Bis-aminopyrimidine derivative 3 DMUNSYX MI TTT7PJU DMUNSYX MN Janus kinase 3 (JAK-3) DMUNSYX MT DTT DMUNSYX MA Inhibitor DMUNSYX RN Inhibitors of JAK-family kinases: an update on the patent literature 2013-2015, part 1.Expert Opin Ther Pat. 2017 Feb;27(2):127-143. DMUNSYX RU https://www.ncbi.nlm.nih.gov/pubmed/27774824 DMUNSYX DI DMUNSYX DMUNSYX DN Bis-aminopyrimidine derivative 3 DMUNSYX MI TTBYWP2 DMUNSYX MN TYK2 tyrosine kinase (TYK2) DMUNSYX MT DTT DMUNSYX MA Inhibitor DMUNSYX RN Inhibitors of JAK-family kinases: an update on the patent literature 2013-2015, part 1.Expert Opin Ther Pat. 2017 Feb;27(2):127-143. DMUNSYX RU https://www.ncbi.nlm.nih.gov/pubmed/27774824 DMO1ZIG DI DMO1ZIG DMO1ZIG DN Bis-aminopyrimidine derivative 4 DMO1ZIG MI TT6DM01 DMO1ZIG MN Janus kinase 1 (JAK-1) DMO1ZIG MT DTT DMO1ZIG MA Inhibitor DMO1ZIG RN Inhibitors of JAK-family kinases: an update on the patent literature 2013-2015, part 1.Expert Opin Ther Pat. 2017 Feb;27(2):127-143. DMO1ZIG RU https://www.ncbi.nlm.nih.gov/pubmed/27774824 DMO1ZIG DI DMO1ZIG DMO1ZIG DN Bis-aminopyrimidine derivative 4 DMO1ZIG MI TTRMX3V DMO1ZIG MN Janus kinase 2 (JAK-2) DMO1ZIG MT DTT DMO1ZIG MA Inhibitor DMO1ZIG RN Inhibitors of JAK-family kinases: an update on the patent literature 2013-2015, part 1.Expert Opin Ther Pat. 2017 Feb;27(2):127-143. DMO1ZIG RU https://www.ncbi.nlm.nih.gov/pubmed/27774824 DMO1ZIG DI DMO1ZIG DMO1ZIG DN Bis-aminopyrimidine derivative 4 DMO1ZIG MI TTT7PJU DMO1ZIG MN Janus kinase 3 (JAK-3) DMO1ZIG MT DTT DMO1ZIG MA Inhibitor DMO1ZIG RN Inhibitors of JAK-family kinases: an update on the patent literature 2013-2015, part 1.Expert Opin Ther Pat. 2017 Feb;27(2):127-143. DMO1ZIG RU https://www.ncbi.nlm.nih.gov/pubmed/27774824 DMO1ZIG DI DMO1ZIG DMO1ZIG DN Bis-aminopyrimidine derivative 4 DMO1ZIG MI TTBYWP2 DMO1ZIG MN TYK2 tyrosine kinase (TYK2) DMO1ZIG MT DTT DMO1ZIG MA Inhibitor DMO1ZIG RN Inhibitors of JAK-family kinases: an update on the patent literature 2013-2015, part 1.Expert Opin Ther Pat. 2017 Feb;27(2):127-143. DMO1ZIG RU https://www.ncbi.nlm.nih.gov/pubmed/27774824 DMWXLK1 DI DMWXLK1 DMWXLK1 DN Bis-aminopyrimidine derivative 5 DMWXLK1 MI TTRMX3V DMWXLK1 MN Janus kinase 2 (JAK-2) DMWXLK1 MT DTT DMWXLK1 MA Inhibitor DMWXLK1 RN Inhibitors of JAK-family kinases: an update on the patent literature 2013-2015, part 1.Expert Opin Ther Pat. 2017 Feb;27(2):127-143. DMWXLK1 RU https://www.ncbi.nlm.nih.gov/pubmed/27774824 DMWXLK1 DI DMWXLK1 DMWXLK1 DN Bis-aminopyrimidine derivative 5 DMWXLK1 MI TTBYWP2 DMWXLK1 MN TYK2 tyrosine kinase (TYK2) DMWXLK1 MT DTT DMWXLK1 MA Inhibitor DMWXLK1 RN Inhibitors of JAK-family kinases: an update on the patent literature 2013-2015, part 1.Expert Opin Ther Pat. 2017 Feb;27(2):127-143. DMWXLK1 RU https://www.ncbi.nlm.nih.gov/pubmed/27774824 DMOR9ZA DI DMOR9ZA DMOR9ZA DN Bis-indolylmaleimide derivative 1 DMOR9ZA MI TTCZOF2 DMOR9ZA MN Pyruvate dehydrogenase kinase 1 (PDHK1) DMOR9ZA MT DTT DMOR9ZA MA Inhibitor DMOR9ZA RN PDK1 disruptors and modulators: a patent review.Expert Opin Ther Pat. 2015 May;25(5):513-37. DMOR9ZA RU https://www.ncbi.nlm.nih.gov/pubmed/25684022 DMLV9UR DI DMLV9UR DMLV9UR DN Bis-sulfonamide derivative 1 DMLV9UR MI TTR7UJ3 DMLV9UR MN Cytoplasmic thioredoxin reductase (TXNRD1) DMLV9UR MT DTT DMLV9UR MA Inhibitor DMLV9UR RN Thioredoxin reductase inhibitors: a patent review.Expert Opin Ther Pat. 2017 May;27(5):547-556. DMLV9UR RU https://www.ncbi.nlm.nih.gov/pubmed/27977313 DMR0ANI DI DMR0ANI DMR0ANI DN Bis-sulfonamide derivative 2 DMR0ANI MI TTR7UJ3 DMR0ANI MN Cytoplasmic thioredoxin reductase (TXNRD1) DMR0ANI MT DTT DMR0ANI MA Inhibitor DMR0ANI RN Thioredoxin reductase inhibitors: a patent review.Expert Opin Ther Pat. 2017 May;27(5):547-556. DMR0ANI RU https://www.ncbi.nlm.nih.gov/pubmed/27977313 DM6YQO3 DI DM6YQO3 DM6YQO3 DN BK3 DM6YQO3 MI TT42OGM DM6YQO3 MN Hematopoietic cell kinase (HCK) DM6YQO3 MT DTT DM6YQO3 MA Inhibitor DM6YQO3 RN Compositions and methods for treating toxoplasmosis, cryptosporidiosis, and other apicomplexan protozoan related diseases. US9765037. DM6YQO3 RU http://www.freepatentsonline.com/US9765037.html DMQD4X2 DI DMQD4X2 DMQD4X2 DN BK7 DMQD4X2 MI TT42OGM DMQD4X2 MN Hematopoietic cell kinase (HCK) DMQD4X2 MT DTT DMQD4X2 MA Inhibitor DMQD4X2 RN Compositions and methods for treating toxoplasmosis, cryptosporidiosis, and other apicomplexan protozoan related diseases. US9765037. DMQD4X2 RU http://www.freepatentsonline.com/US9765037.html DMMRXEQ DI DMMRXEQ DMMRXEQ DN Boronic acid derivative 1 DMMRXEQ MI TTDP1UC DMMRXEQ MN Fatty acid amide hydrolase (FAAH) DMMRXEQ MT DTT DMMRXEQ MA Inhibitor DMMRXEQ RN Fatty acid amide hydrolase inhibitors: a patent review (2009-2014).Expert Opin Ther Pat. 2015;25(11):1247-66. DMMRXEQ RU https://www.ncbi.nlm.nih.gov/pubmed/26413912 DMLJH5T DI DMLJH5T DMLJH5T DN Boronic acid derivative 2 DMLJH5T MI TTDP1UC DMLJH5T MN Fatty acid amide hydrolase (FAAH) DMLJH5T MT DTT DMLJH5T MA Inhibitor DMLJH5T RN Fatty acid amide hydrolase inhibitors: a patent review (2009-2014).Expert Opin Ther Pat. 2015;25(11):1247-66. DMLJH5T RU https://www.ncbi.nlm.nih.gov/pubmed/26413912 DMQ8X94 DI DMQ8X94 DMQ8X94 DN Boronic acid derivative 3 DMQ8X94 MI TTDP1UC DMQ8X94 MN Fatty acid amide hydrolase (FAAH) DMQ8X94 MT DTT DMQ8X94 MA Inhibitor DMQ8X94 RN Fatty acid amide hydrolase inhibitors: a patent review (2009-2014).Expert Opin Ther Pat. 2015;25(11):1247-66. DMQ8X94 RU https://www.ncbi.nlm.nih.gov/pubmed/26413912 DMVIFXR DI DMVIFXR DMVIFXR DN Boronic acid derivative 4 DMVIFXR MI TTDP1UC DMVIFXR MN Fatty acid amide hydrolase (FAAH) DMVIFXR MT DTT DMVIFXR MA Inhibitor DMVIFXR RN Fatty acid amide hydrolase inhibitors: a patent review (2009-2014).Expert Opin Ther Pat. 2015;25(11):1247-66. DMVIFXR RU https://www.ncbi.nlm.nih.gov/pubmed/26413912 DMUCW9Y DI DMUCW9Y DMUCW9Y DN Boronic acid derivative 5 DMUCW9Y MI TTDP1UC DMUCW9Y MN Fatty acid amide hydrolase (FAAH) DMUCW9Y MT DTT DMUCW9Y MA Inhibitor DMUCW9Y RN Fatty acid amide hydrolase inhibitors: a patent review (2009-2014).Expert Opin Ther Pat. 2015;25(11):1247-66. DMUCW9Y RU https://www.ncbi.nlm.nih.gov/pubmed/26413912 DMLMV4O DI DMLMV4O DMLMV4O DN Boronic acid derivative 6 DMLMV4O MI TTDP1UC DMLMV4O MN Fatty acid amide hydrolase (FAAH) DMLMV4O MT DTT DMLMV4O MA Inhibitor DMLMV4O RN Fatty acid amide hydrolase inhibitors: a patent review (2009-2014).Expert Opin Ther Pat. 2015;25(11):1247-66. DMLMV4O RU https://www.ncbi.nlm.nih.gov/pubmed/26413912 DMCLB5D DI DMCLB5D DMCLB5D DN Boswellia acid derivative 1 DMCLB5D MI TTYLQ8V DMCLB5D MN Prostaglandin E synthase (PTGES) DMCLB5D MT DTT DMCLB5D MA Inhibitor DMCLB5D RN Microsomal prostaglandin E2 synthase-1 inhibitors: a patent review.Expert Opin Ther Pat. 2017 Sep;27(9):1047-1059. DMCLB5D RU https://www.ncbi.nlm.nih.gov/pubmed/28627961 DMMXQJU DI DMMXQJU DMMXQJU DN Bromo benzyl ether derivative 1 DMMXQJU MI TT23XQV DMMXQJU MN PD-1-PD-L1 interaction (PD-1/PD-L1 PPI) DMMXQJU MT DTT DMMXQJU MA Inhibitor DMMXQJU RN A patent review on PD-1/PD-L1 antagonists: small molecules, peptides, and macrocycles (2015-2018).Expert Opin Ther Pat. 2018 Sep;28(9):665-678. DMMXQJU RU https://www.ncbi.nlm.nih.gov/pubmed/30107136 DMVBAUC DI DMVBAUC DMVBAUC DN Bromo benzyl ether derivative 2 DMVBAUC MI TT23XQV DMVBAUC MN PD-1-PD-L1 interaction (PD-1/PD-L1 PPI) DMVBAUC MT DTT DMVBAUC MA Inhibitor DMVBAUC RN A patent review on PD-1/PD-L1 antagonists: small molecules, peptides, and macrocycles (2015-2018).Expert Opin Ther Pat. 2018 Sep;28(9):665-678. DMVBAUC RU https://www.ncbi.nlm.nih.gov/pubmed/30107136 DMVYNJZ DI DMVYNJZ DMVYNJZ DN BUTAPROST DMVYNJZ MI TTG1QMU DMVYNJZ MN Prostaglandin E2 receptor EP1 (PTGER1) DMVYNJZ MT DTT DMVYNJZ MA Antagonist DMVYNJZ RN Evaluation of WO 2012/177618 A1 and US-2014/0179750 A1: novel small molecule antagonists of prostaglandin-E2 receptor EP2.Expert Opin Ther Pat. 2015 Jul;25(7):837-44. DMVYNJZ RU https://www.ncbi.nlm.nih.gov/pubmed/25772215 DMVYNJZ DI DMVYNJZ DMVYNJZ DN BUTAPROST DMVYNJZ MI TT1ZAVI DMVYNJZ MN Prostaglandin E2 receptor EP2 (PTGER2) DMVYNJZ MT DTT DMVYNJZ MA Antagonist DMVYNJZ RN Evaluation of WO 2012/177618 A1 and US-2014/0179750 A1: novel small molecule antagonists of prostaglandin-E2 receptor EP2.Expert Opin Ther Pat. 2015 Jul;25(7):837-44. DMVYNJZ RU https://www.ncbi.nlm.nih.gov/pubmed/25772215 DMVYNJZ DI DMVYNJZ DMVYNJZ DN BUTAPROST DMVYNJZ MI TTPNGDE DMVYNJZ MN Prostaglandin E2 receptor EP3 (PTGER3) DMVYNJZ MT DTT DMVYNJZ MA Antagonist DMVYNJZ RN Evaluation of WO 2012/177618 A1 and US-2014/0179750 A1: novel small molecule antagonists of prostaglandin-E2 receptor EP2.Expert Opin Ther Pat. 2015 Jul;25(7):837-44. DMVYNJZ RU https://www.ncbi.nlm.nih.gov/pubmed/25772215 DMVYNJZ DI DMVYNJZ DMVYNJZ DN BUTAPROST DMVYNJZ MI TT79WV3 DMVYNJZ MN Prostaglandin E2 receptor EP4 (PTGER4) DMVYNJZ MT DTT DMVYNJZ MA Antagonist DMVYNJZ RN Evaluation of WO 2012/177618 A1 and US-2014/0179750 A1: novel small molecule antagonists of prostaglandin-E2 receptor EP2.Expert Opin Ther Pat. 2015 Jul;25(7):837-44. DMVYNJZ RU https://www.ncbi.nlm.nih.gov/pubmed/25772215 DMVYNJZ DI DMVYNJZ DMVYNJZ DN BUTAPROST DMVYNJZ MI TTT2ZAR DMVYNJZ MN Prostaglandin F2-alpha receptor (PTGFR) DMVYNJZ MT DTT DMVYNJZ MA Antagonist DMVYNJZ RN Evaluation of WO 2012/177618 A1 and US-2014/0179750 A1: novel small molecule antagonists of prostaglandin-E2 receptor EP2.Expert Opin Ther Pat. 2015 Jul;25(7):837-44. DMVYNJZ RU https://www.ncbi.nlm.nih.gov/pubmed/25772215 DMJPW7C DI DMJPW7C DMJPW7C DN C06909 DMJPW7C MI TT5DOVB DMJPW7C MN Cytomegalovirus Protease (CMV UL80) DMJPW7C MT DTT DMJPW7C MA Inhibitor DMJPW7C RN Phosphonate compounds. US10071110. DMJPW7C RU http://www.freepatentsonline.com/US10071110.html DMW46GY DI DMW46GY DMW46GY DN CAMBINOL DMW46GY MI TTUF2HO DMW46GY MN NAD-dependent deacetylase sirtuin-1 (SIRT1) DMW46GY MT DTT DMW46GY MA Inhibitor DMW46GY RN Novel cambinol analogs as sirtuin inhibitors: synthesis, biological evaluation, and rationalization of activity. J Med Chem. 2009 May 14;52(9):2673-82. DMW46GY RU https://pubmed.ncbi.nlm.nih.gov/19419202 DM81SYN DI DM81SYN DM81SYN DN Cannabinoid quinone derivative 1 DM81SYN MI TTZMAO3 DM81SYN MN Peroxisome proliferator-activated receptor gamma (PPAR-gamma) DM81SYN MT DTT DM81SYN MA Ligand DM81SYN RN PPAR ligands and their therapeutic applications: a patent review (2008 - 2014).Expert Opin Ther Pat. 2015 Feb;25(2):175-91. DM81SYN RU https://www.ncbi.nlm.nih.gov/pubmed/25416646 DMNDPEA DI DMNDPEA DMNDPEA DN Carbamate derivative 1 DMNDPEA MI TTDP1UC DMNDPEA MN Fatty acid amide hydrolase (FAAH) DMNDPEA MT DTT DMNDPEA MA Inhibitor DMNDPEA RN Fatty acid amide hydrolase inhibitors: a patent review (2009-2014).Expert Opin Ther Pat. 2015;25(11):1247-66. DMNDPEA RU https://www.ncbi.nlm.nih.gov/pubmed/26413912 DMP98CL DI DMP98CL DMP98CL DN Carbamate derivative 10 DMP98CL MI TTDP1UC DMP98CL MN Fatty acid amide hydrolase (FAAH) DMP98CL MT DTT DMP98CL MA Inhibitor DMP98CL RN A patent review of Monoacylglycerol Lipase (MAGL) inhibitors (2013-2017).Expert Opin Ther Pat. 2017 Dec;27(12):1341-1351. DMP98CL RU https://www.ncbi.nlm.nih.gov/pubmed/29053063 DMP98CL DI DMP98CL DMP98CL DN Carbamate derivative 10 DMP98CL MI TTZ963I DMP98CL MN Monoglyceride lipase (MAGL) DMP98CL MT DTT DMP98CL MA Inhibitor DMP98CL RN A patent review of Monoacylglycerol Lipase (MAGL) inhibitors (2013-2017).Expert Opin Ther Pat. 2017 Dec;27(12):1341-1351. DMP98CL RU https://www.ncbi.nlm.nih.gov/pubmed/29053063 DM3CF91 DI DM3CF91 DM3CF91 DN Carbamate derivative 11 DM3CF91 MI TTZ963I DM3CF91 MN Monoglyceride lipase (MAGL) DM3CF91 MT DTT DM3CF91 MA Inhibitor DM3CF91 RN A patent review of Monoacylglycerol Lipase (MAGL) inhibitors (2013-2017).Expert Opin Ther Pat. 2017 Dec;27(12):1341-1351. DM3CF91 RU https://www.ncbi.nlm.nih.gov/pubmed/29053063 DMMH27J DI DMMH27J DMMH27J DN Carbamate derivative 12 DMMH27J MI TTZ963I DMMH27J MN Monoglyceride lipase (MAGL) DMMH27J MT DTT DMMH27J MA Inhibitor DMMH27J RN A patent review of Monoacylglycerol Lipase (MAGL) inhibitors (2013-2017).Expert Opin Ther Pat. 2017 Dec;27(12):1341-1351. DMMH27J RU https://www.ncbi.nlm.nih.gov/pubmed/29053063 DMLH45M DI DMLH45M DMLH45M DN Carbamate derivative 13 DMLH45M MI TTZ963I DMLH45M MN Monoglyceride lipase (MAGL) DMLH45M MT DTT DMLH45M MA Inhibitor DMLH45M RN A patent review of Monoacylglycerol Lipase (MAGL) inhibitors (2013-2017).Expert Opin Ther Pat. 2017 Dec;27(12):1341-1351. DMLH45M RU https://www.ncbi.nlm.nih.gov/pubmed/29053063 DMZS0HT DI DMZS0HT DMZS0HT DN Carbamate derivative 14 DMZS0HT MI TTZ963I DMZS0HT MN Monoglyceride lipase (MAGL) DMZS0HT MT DTT DMZS0HT MA Inhibitor DMZS0HT RN A patent review of Monoacylglycerol Lipase (MAGL) inhibitors (2013-2017).Expert Opin Ther Pat. 2017 Dec;27(12):1341-1351. DMZS0HT RU https://www.ncbi.nlm.nih.gov/pubmed/29053063 DMOKC41 DI DMOKC41 DMOKC41 DN Carbamate derivative 15 DMOKC41 MI TTZ963I DMOKC41 MN Monoglyceride lipase (MAGL) DMOKC41 MT DTT DMOKC41 MA Inhibitor DMOKC41 RN A patent review of Monoacylglycerol Lipase (MAGL) inhibitors (2013-2017).Expert Opin Ther Pat. 2017 Dec;27(12):1341-1351. DMOKC41 RU https://www.ncbi.nlm.nih.gov/pubmed/29053063 DMPLZSE DI DMPLZSE DMPLZSE DN Carbamate derivative 16 DMPLZSE MI TTDP1UC DMPLZSE MN Fatty acid amide hydrolase (FAAH) DMPLZSE MT DTT DMPLZSE MA Inhibitor DMPLZSE RN A patent review of Monoacylglycerol Lipase (MAGL) inhibitors (2013-2017).Expert Opin Ther Pat. 2017 Dec;27(12):1341-1351. DMPLZSE RU https://www.ncbi.nlm.nih.gov/pubmed/29053063 DMPLZSE DI DMPLZSE DMPLZSE DN Carbamate derivative 16 DMPLZSE MI TTZ963I DMPLZSE MN Monoglyceride lipase (MAGL) DMPLZSE MT DTT DMPLZSE MA Inhibitor DMPLZSE RN A patent review of Monoacylglycerol Lipase (MAGL) inhibitors (2013-2017).Expert Opin Ther Pat. 2017 Dec;27(12):1341-1351. DMPLZSE RU https://www.ncbi.nlm.nih.gov/pubmed/29053063 DMYSRPT DI DMYSRPT DMYSRPT DN Carbamate derivative 17 DMYSRPT MI TTDP1UC DMYSRPT MN Fatty acid amide hydrolase (FAAH) DMYSRPT MT DTT DMYSRPT MA Inhibitor DMYSRPT RN A patent review of Monoacylglycerol Lipase (MAGL) inhibitors (2013-2017).Expert Opin Ther Pat. 2017 Dec;27(12):1341-1351. DMYSRPT RU https://www.ncbi.nlm.nih.gov/pubmed/29053063 DMYSRPT DI DMYSRPT DMYSRPT DN Carbamate derivative 17 DMYSRPT MI TTZ963I DMYSRPT MN Monoglyceride lipase (MAGL) DMYSRPT MT DTT DMYSRPT MA Inhibitor DMYSRPT RN A patent review of Monoacylglycerol Lipase (MAGL) inhibitors (2013-2017).Expert Opin Ther Pat. 2017 Dec;27(12):1341-1351. DMYSRPT RU https://www.ncbi.nlm.nih.gov/pubmed/29053063 DMEWPQ6 DI DMEWPQ6 DMEWPQ6 DN Carbamate derivative 2 DMEWPQ6 MI TTGX13H DMEWPQ6 MN Fatty-acid amide hydrolase 1 (FAAH1) DMEWPQ6 MT DTT DMEWPQ6 MA Inhibitor DMEWPQ6 RN Fatty acid amide hydrolase inhibitors: a patent review (2009-2014).Expert Opin Ther Pat. 2015;25(11):1247-66. DMEWPQ6 RU https://www.ncbi.nlm.nih.gov/pubmed/26413912 DMEWPQ6 DI DMEWPQ6 DMEWPQ6 DN Carbamate derivative 2 DMEWPQ6 MI TT8NGED DMEWPQ6 MN Prostaglandin G/H synthase 1 (COX-1) DMEWPQ6 MT DTT DMEWPQ6 MA Inhibitor DMEWPQ6 RN Fatty acid amide hydrolase inhibitors: a patent review (2009-2014).Expert Opin Ther Pat. 2015;25(11):1247-66. DMEWPQ6 RU https://www.ncbi.nlm.nih.gov/pubmed/26413912 DMEWPQ6 DI DMEWPQ6 DMEWPQ6 DN Carbamate derivative 2 DMEWPQ6 MI TTVKILB DMEWPQ6 MN Prostaglandin G/H synthase 2 (COX-2) DMEWPQ6 MT DTT DMEWPQ6 MA Inhibitor DMEWPQ6 RN Fatty acid amide hydrolase inhibitors: a patent review (2009-2014).Expert Opin Ther Pat. 2015;25(11):1247-66. DMEWPQ6 RU https://www.ncbi.nlm.nih.gov/pubmed/26413912 DMO6NWD DI DMO6NWD DMO6NWD DN Carbamate derivative 3 DMO6NWD MI TTDP1UC DMO6NWD MN Fatty acid amide hydrolase (FAAH) DMO6NWD MT DTT DMO6NWD MA Inhibitor DMO6NWD RN Fatty acid amide hydrolase inhibitors: a patent review (2009-2014).Expert Opin Ther Pat. 2015;25(11):1247-66. DMO6NWD RU https://www.ncbi.nlm.nih.gov/pubmed/26413912 DM9MFDH DI DM9MFDH DM9MFDH DN Carbamate derivative 4 DM9MFDH MI TTGX13H DM9MFDH MN Fatty-acid amide hydrolase 1 (FAAH1) DM9MFDH MT DTT DM9MFDH MA Inhibitor DM9MFDH RN Fatty acid amide hydrolase inhibitors: a patent review (2009-2014).Expert Opin Ther Pat. 2015;25(11):1247-66. DM9MFDH RU https://www.ncbi.nlm.nih.gov/pubmed/26413912 DMHB5XG DI DMHB5XG DMHB5XG DN Carbamate derivative 5 DMHB5XG MI TTGX13H DMHB5XG MN Fatty-acid amide hydrolase 1 (FAAH1) DMHB5XG MT DTT DMHB5XG MA Inhibitor DMHB5XG RN Fatty acid amide hydrolase inhibitors: a patent review (2009-2014).Expert Opin Ther Pat. 2015;25(11):1247-66. DMHB5XG RU https://www.ncbi.nlm.nih.gov/pubmed/26413912 DMMOSKZ DI DMMOSKZ DMMOSKZ DN Carbamate derivative 6 DMMOSKZ MI TTGX13H DMMOSKZ MN Fatty-acid amide hydrolase 1 (FAAH1) DMMOSKZ MT DTT DMMOSKZ MA Inhibitor DMMOSKZ RN Fatty acid amide hydrolase inhibitors: a patent review (2009-2014).Expert Opin Ther Pat. 2015;25(11):1247-66. DMMOSKZ RU https://www.ncbi.nlm.nih.gov/pubmed/26413912 DMOPF9N DI DMOPF9N DMOPF9N DN Carbamate derivative 7 DMOPF9N MI TTDP1UC DMOPF9N MN Fatty acid amide hydrolase (FAAH) DMOPF9N MT DTT DMOPF9N MA Inhibitor DMOPF9N RN Fatty acid amide hydrolase inhibitors: a patent review (2009-2014).Expert Opin Ther Pat. 2015;25(11):1247-66. DMOPF9N RU https://www.ncbi.nlm.nih.gov/pubmed/26413912 DMEAO42 DI DMEAO42 DMEAO42 DN Carbamate derivative 8 DMEAO42 MI TTDP1UC DMEAO42 MN Fatty acid amide hydrolase (FAAH) DMEAO42 MT DTT DMEAO42 MA Inhibitor DMEAO42 RN Fatty acid amide hydrolase inhibitors: a patent review (2009-2014).Expert Opin Ther Pat. 2015;25(11):1247-66. DMEAO42 RU https://www.ncbi.nlm.nih.gov/pubmed/26413912 DMW4B1U DI DMW4B1U DMW4B1U DN Carbamate derivative 9 DMW4B1U MI TTDP1UC DMW4B1U MN Fatty acid amide hydrolase (FAAH) DMW4B1U MT DTT DMW4B1U MA Inhibitor DMW4B1U RN A patent review of Monoacylglycerol Lipase (MAGL) inhibitors (2013-2017).Expert Opin Ther Pat. 2017 Dec;27(12):1341-1351. DMW4B1U RU https://www.ncbi.nlm.nih.gov/pubmed/29053063 DMW4B1U DI DMW4B1U DMW4B1U DN Carbamate derivative 9 DMW4B1U MI TTZ963I DMW4B1U MN Monoglyceride lipase (MAGL) DMW4B1U MT DTT DMW4B1U MA Inhibitor DMW4B1U RN A patent review of Monoacylglycerol Lipase (MAGL) inhibitors (2013-2017).Expert Opin Ther Pat. 2017 Dec;27(12):1341-1351. DMW4B1U RU https://www.ncbi.nlm.nih.gov/pubmed/29053063 DMXQTPJ DI DMXQTPJ DMXQTPJ DN Carbamide derivative 1 DMXQTPJ MI TTDP1UC DMXQTPJ MN Fatty acid amide hydrolase (FAAH) DMXQTPJ MT DTT DMXQTPJ MA Inhibitor DMXQTPJ RN Fatty acid amide hydrolase inhibitors: a patent review (2009-2014).Expert Opin Ther Pat. 2015;25(11):1247-66. DMXQTPJ RU https://www.ncbi.nlm.nih.gov/pubmed/26413912 DMXQTPJ DI DMXQTPJ DMXQTPJ DN Carbamide derivative 1 DMXQTPJ MI TTGX13H DMXQTPJ MN Fatty-acid amide hydrolase 1 (FAAH1) DMXQTPJ MT DTT DMXQTPJ MA Inhibitor DMXQTPJ RN Fatty acid amide hydrolase inhibitors: a patent review (2009-2014).Expert Opin Ther Pat. 2015;25(11):1247-66. DMXQTPJ RU https://www.ncbi.nlm.nih.gov/pubmed/26413912 DM9O56W DI DM9O56W DM9O56W DN Carbamide derivative 10 DM9O56W MI TTL7C8Q DM9O56W MN Inosine-5'-monophosphate dehydrogenase 1 (IMPDH1) DM9O56W MT DTT DM9O56W MA Inhibitor DM9O56W RN Inosine-5'-monophosphate dehydrogenase (IMPDH) inhibitors: a patent and scientific literature review (2002-2016).Expert Opin Ther Pat. 2017 Jun;27(6):677-690. DM9O56W RU https://www.ncbi.nlm.nih.gov/pubmed/28074661 DMK7DJR DI DMK7DJR DMK7DJR DN Carbamide derivative 11 DMK7DJR MI TTL7C8Q DMK7DJR MN Inosine-5'-monophosphate dehydrogenase 1 (IMPDH1) DMK7DJR MT DTT DMK7DJR MA Inhibitor DMK7DJR RN Inosine-5'-monophosphate dehydrogenase (IMPDH) inhibitors: a patent and scientific literature review (2002-2016).Expert Opin Ther Pat. 2017 Jun;27(6):677-690. DMK7DJR RU https://www.ncbi.nlm.nih.gov/pubmed/28074661 DMCAD64 DI DMCAD64 DMCAD64 DN Carbamide derivative 13 DMCAD64 MI TTZJYKH DMCAD64 MN Indoleamine 2,3-dioxygenase 1 (IDO1) DMCAD64 MT DTT DMCAD64 MA Inhibitor DMCAD64 RN A patent review of IDO1 inhibitors for cancer.Expert Opin Ther Pat. 2018 Apr;28(4):317-330. DMCAD64 RU https://www.ncbi.nlm.nih.gov/pubmed/29473428 DMU04PM DI DMU04PM DMU04PM DN Carbamide derivative 14 DMU04PM MI TTOHSBA DMU04PM MN Vascular endothelial growth factor A (VEGFA) DMU04PM MT DTT DMU04PM MA Inhibitor DMU04PM RN VEGFR-2 inhibitors and the therapeutic applications thereof: a patent review (2012-2016).Expert Opin Ther Pat. 2017 Sep;27(9):987-1004. DMU04PM RU https://www.ncbi.nlm.nih.gov/pubmed/28621580 DM2TDXW DI DM2TDXW DM2TDXW DN Carbamide derivative 15 DM2TDXW MI TTOHSBA DM2TDXW MN Vascular endothelial growth factor A (VEGFA) DM2TDXW MT DTT DM2TDXW MA Inhibitor DM2TDXW RN VEGFR-2 inhibitors and the therapeutic applications thereof: a patent review (2012-2016).Expert Opin Ther Pat. 2017 Sep;27(9):987-1004. DM2TDXW RU https://www.ncbi.nlm.nih.gov/pubmed/28621580 DMLPOUR DI DMLPOUR DMLPOUR DN Carbamide derivative 16 DMLPOUR MI TTOHSBA DMLPOUR MN Vascular endothelial growth factor A (VEGFA) DMLPOUR MT DTT DMLPOUR MA Inhibitor DMLPOUR RN VEGFR-2 inhibitors and the therapeutic applications thereof: a patent review (2012-2016).Expert Opin Ther Pat. 2017 Sep;27(9):987-1004. DMLPOUR RU https://www.ncbi.nlm.nih.gov/pubmed/28621580 DMUF5AC DI DMUF5AC DMUF5AC DN Carbamide derivative 17 DMUF5AC MI TTOHSBA DMUF5AC MN Vascular endothelial growth factor A (VEGFA) DMUF5AC MT DTT DMUF5AC MA Inhibitor DMUF5AC RN VEGFR-2 inhibitors and the therapeutic applications thereof: a patent review (2012-2016).Expert Opin Ther Pat. 2017 Sep;27(9):987-1004. DMUF5AC RU https://www.ncbi.nlm.nih.gov/pubmed/28621580 DMZ37XI DI DMZ37XI DMZ37XI DN Carbamide derivative 18 DMZ37XI MI TTOHSBA DMZ37XI MN Vascular endothelial growth factor A (VEGFA) DMZ37XI MT DTT DMZ37XI MA Inhibitor DMZ37XI RN VEGFR-2 inhibitors and the therapeutic applications thereof: a patent review (2012-2016).Expert Opin Ther Pat. 2017 Sep;27(9):987-1004. DMZ37XI RU https://www.ncbi.nlm.nih.gov/pubmed/28621580 DMLDXOB DI DMLDXOB DMLDXOB DN Carbamide derivative 19 DMLDXOB MI TTOHSBA DMLDXOB MN Vascular endothelial growth factor A (VEGFA) DMLDXOB MT DTT DMLDXOB MA Inhibitor DMLDXOB RN VEGFR-2 inhibitors and the therapeutic applications thereof: a patent review (2012-2016).Expert Opin Ther Pat. 2017 Sep;27(9):987-1004. DMLDXOB RU https://www.ncbi.nlm.nih.gov/pubmed/28621580 DMW5GI3 DI DMW5GI3 DMW5GI3 DN Carbamide derivative 2 DMW5GI3 MI TTO9X1H DMW5GI3 MN 5-HT 7 receptor (HTR7) DMW5GI3 MT DTT DMW5GI3 MA Inhibitor DMW5GI3 RN Acyltransferase inhibitors: a patent review (2010-present).Expert Opin Ther Pat. 2015 Feb;25(2):145-58. DMW5GI3 RU https://www.ncbi.nlm.nih.gov/pubmed/25470667 DMYSWG1 DI DMYSWG1 DMYSWG1 DN Carbamide derivative 20 DMYSWG1 MI TTOHSBA DMYSWG1 MN Vascular endothelial growth factor A (VEGFA) DMYSWG1 MT DTT DMYSWG1 MA Inhibitor DMYSWG1 RN VEGFR-2 inhibitors and the therapeutic applications thereof: a patent review (2012-2016).Expert Opin Ther Pat. 2017 Sep;27(9):987-1004. DMYSWG1 RU https://www.ncbi.nlm.nih.gov/pubmed/28621580 DMD03J5 DI DMD03J5 DMD03J5 DN Carbamide derivative 21 DMD03J5 MI TTOHSBA DMD03J5 MN Vascular endothelial growth factor A (VEGFA) DMD03J5 MT DTT DMD03J5 MA Inhibitor DMD03J5 RN VEGFR-2 inhibitors and the therapeutic applications thereof: a patent review (2012-2016).Expert Opin Ther Pat. 2017 Sep;27(9):987-1004. DMD03J5 RU https://www.ncbi.nlm.nih.gov/pubmed/28621580 DMC3TJI DI DMC3TJI DMC3TJI DN Carbamide derivative 22 DMC3TJI MI TTOHSBA DMC3TJI MN Vascular endothelial growth factor A (VEGFA) DMC3TJI MT DTT DMC3TJI MA Inhibitor DMC3TJI RN VEGFR-2 inhibitors and the therapeutic applications thereof: a patent review (2012-2016).Expert Opin Ther Pat. 2017 Sep;27(9):987-1004. DMC3TJI RU https://www.ncbi.nlm.nih.gov/pubmed/28621580 DM0IRPO DI DM0IRPO DM0IRPO DN Carbamide derivative 23 DM0IRPO MI TTOHSBA DM0IRPO MN Vascular endothelial growth factor A (VEGFA) DM0IRPO MT DTT DM0IRPO MA Inhibitor DM0IRPO RN VEGFR-2 inhibitors and the therapeutic applications thereof: a patent review (2012-2016).Expert Opin Ther Pat. 2017 Sep;27(9):987-1004. DM0IRPO RU https://www.ncbi.nlm.nih.gov/pubmed/28621580 DMD6Y73 DI DMD6Y73 DMD6Y73 DN Carbamide derivative 24 DMD6Y73 MI TTDP1UC DMD6Y73 MN Fatty acid amide hydrolase (FAAH) DMD6Y73 MT DTT DMD6Y73 MA Inhibitor DMD6Y73 RN A patent review of Monoacylglycerol Lipase (MAGL) inhibitors (2013-2017).Expert Opin Ther Pat. 2017 Dec;27(12):1341-1351. DMD6Y73 RU https://www.ncbi.nlm.nih.gov/pubmed/29053063 DMD6Y73 DI DMD6Y73 DMD6Y73 DN Carbamide derivative 24 DMD6Y73 MI TTZ963I DMD6Y73 MN Monoglyceride lipase (MAGL) DMD6Y73 MT DTT DMD6Y73 MA Inhibitor DMD6Y73 RN A patent review of Monoacylglycerol Lipase (MAGL) inhibitors (2013-2017).Expert Opin Ther Pat. 2017 Dec;27(12):1341-1351. DMD6Y73 RU https://www.ncbi.nlm.nih.gov/pubmed/29053063 DM8ONCL DI DM8ONCL DM8ONCL DN Carbamide derivative 25 DM8ONCL MI TTDP1UC DM8ONCL MN Fatty acid amide hydrolase (FAAH) DM8ONCL MT DTT DM8ONCL MA Inhibitor DM8ONCL RN A patent review of Monoacylglycerol Lipase (MAGL) inhibitors (2013-2017).Expert Opin Ther Pat. 2017 Dec;27(12):1341-1351. DM8ONCL RU https://www.ncbi.nlm.nih.gov/pubmed/29053063 DM8ONCL DI DM8ONCL DM8ONCL DN Carbamide derivative 25 DM8ONCL MI TTZ963I DM8ONCL MN Monoglyceride lipase (MAGL) DM8ONCL MT DTT DM8ONCL MA Inhibitor DM8ONCL RN A patent review of Monoacylglycerol Lipase (MAGL) inhibitors (2013-2017).Expert Opin Ther Pat. 2017 Dec;27(12):1341-1351. DM8ONCL RU https://www.ncbi.nlm.nih.gov/pubmed/29053063 DMDU9XF DI DMDU9XF DMDU9XF DN Carbamide derivative 26 DMDU9XF MI TTDP1UC DMDU9XF MN Fatty acid amide hydrolase (FAAH) DMDU9XF MT DTT DMDU9XF MA Inhibitor DMDU9XF RN A patent review of Monoacylglycerol Lipase (MAGL) inhibitors (2013-2017).Expert Opin Ther Pat. 2017 Dec;27(12):1341-1351. DMDU9XF RU https://www.ncbi.nlm.nih.gov/pubmed/29053063 DMDU9XF DI DMDU9XF DMDU9XF DN Carbamide derivative 26 DMDU9XF MI TTZ963I DMDU9XF MN Monoglyceride lipase (MAGL) DMDU9XF MT DTT DMDU9XF MA Inhibitor DMDU9XF RN A patent review of Monoacylglycerol Lipase (MAGL) inhibitors (2013-2017).Expert Opin Ther Pat. 2017 Dec;27(12):1341-1351. DMDU9XF RU https://www.ncbi.nlm.nih.gov/pubmed/29053063 DM4ISCQ DI DM4ISCQ DM4ISCQ DN Carbamide derivative 3 DM4ISCQ MI TTF8P9I DM4ISCQ MN Diacylglycerol acyltransferase 1 (DGAT1) DM4ISCQ MT DTT DM4ISCQ MA Inhibitor DM4ISCQ RN Acyltransferase inhibitors: a patent review (2010-present).Expert Opin Ther Pat. 2015 Feb;25(2):145-58. DM4ISCQ RU https://www.ncbi.nlm.nih.gov/pubmed/25470667 DM5V2D9 DI DM5V2D9 DM5V2D9 DN Carbamide derivative 4 DM5V2D9 MI TTL7C8Q DM5V2D9 MN Inosine-5'-monophosphate dehydrogenase 1 (IMPDH1) DM5V2D9 MT DTT DM5V2D9 MA Inhibitor DM5V2D9 RN Inosine-5'-monophosphate dehydrogenase (IMPDH) inhibitors: a patent and scientific literature review (2002-2016).Expert Opin Ther Pat. 2017 Jun;27(6):677-690. DM5V2D9 RU https://www.ncbi.nlm.nih.gov/pubmed/28074661 DM951HL DI DM951HL DM951HL DN Carbamide derivative 5 DM951HL MI TTL7C8Q DM951HL MN Inosine-5'-monophosphate dehydrogenase 1 (IMPDH1) DM951HL MT DTT DM951HL MA Inhibitor DM951HL RN Inosine-5'-monophosphate dehydrogenase (IMPDH) inhibitors: a patent and scientific literature review (2002-2016).Expert Opin Ther Pat. 2017 Jun;27(6):677-690. DM951HL RU https://www.ncbi.nlm.nih.gov/pubmed/28074661 DMORBE3 DI DMORBE3 DMORBE3 DN Carbamide derivative 6 DMORBE3 MI TTL7C8Q DMORBE3 MN Inosine-5'-monophosphate dehydrogenase 1 (IMPDH1) DMORBE3 MT DTT DMORBE3 MA Inhibitor DMORBE3 RN Inosine-5'-monophosphate dehydrogenase (IMPDH) inhibitors: a patent and scientific literature review (2002-2016).Expert Opin Ther Pat. 2017 Jun;27(6):677-690. DMORBE3 RU https://www.ncbi.nlm.nih.gov/pubmed/28074661 DMWKXN4 DI DMWKXN4 DMWKXN4 DN Carbamide derivative 7 DMWKXN4 MI TTL7C8Q DMWKXN4 MN Inosine-5'-monophosphate dehydrogenase 1 (IMPDH1) DMWKXN4 MT DTT DMWKXN4 MA Inhibitor DMWKXN4 RN Inosine-5'-monophosphate dehydrogenase (IMPDH) inhibitors: a patent and scientific literature review (2002-2016).Expert Opin Ther Pat. 2017 Jun;27(6):677-690. DMWKXN4 RU https://www.ncbi.nlm.nih.gov/pubmed/28074661 DMZ3FJO DI DMZ3FJO DMZ3FJO DN Carbamide derivative 8 DMZ3FJO MI TTL7C8Q DMZ3FJO MN Inosine-5'-monophosphate dehydrogenase 1 (IMPDH1) DMZ3FJO MT DTT DMZ3FJO MA Inhibitor DMZ3FJO RN Inosine-5'-monophosphate dehydrogenase (IMPDH) inhibitors: a patent and scientific literature review (2002-2016).Expert Opin Ther Pat. 2017 Jun;27(6):677-690. DMZ3FJO RU https://www.ncbi.nlm.nih.gov/pubmed/28074661 DMY06VC DI DMY06VC DMY06VC DN Carbamide derivative 9 DMY06VC MI TTL7C8Q DMY06VC MN Inosine-5'-monophosphate dehydrogenase 1 (IMPDH1) DMY06VC MT DTT DMY06VC MA Inhibitor DMY06VC RN Inosine-5'-monophosphate dehydrogenase (IMPDH) inhibitors: a patent and scientific literature review (2002-2016).Expert Opin Ther Pat. 2017 Jun;27(6):677-690. DMY06VC RU https://www.ncbi.nlm.nih.gov/pubmed/28074661 DM0EBS8 DI DM0EBS8 DM0EBS8 DN Carbamoyl oxime derivative 1 DM0EBS8 MI TTGX13H DM0EBS8 MN Fatty-acid amide hydrolase 1 (FAAH1) DM0EBS8 MT DTT DM0EBS8 MA Inhibitor DM0EBS8 RN Fatty acid amide hydrolase inhibitors: a patent review (2009-2014).Expert Opin Ther Pat. 2015;25(11):1247-66. DM0EBS8 RU https://www.ncbi.nlm.nih.gov/pubmed/26413912 DM3B5RS DI DM3B5RS DM3B5RS DN Carbazole-3-carboxamide analog 1 DM3B5RS MI TT6OEDT DM3B5RS MN Cannabinoid receptor 1 (CB1) DM3B5RS MT DTT DM3B5RS MA Agonist DM3B5RS RN Cannabinoid receptor 2 (CB2) agonists and antagonists: a patent update.Expert Opin Ther Pat. 2016 Jul;26(7):843-56. DM3B5RS RU https://www.ncbi.nlm.nih.gov/pubmed/27215781 DM3B5RS DI DM3B5RS DM3B5RS DN Carbazole-3-carboxamide analog 1 DM3B5RS MI TTMSFAW DM3B5RS MN Cannabinoid receptor 2 (CB2) DM3B5RS MT DTT DM3B5RS MA Agonist DM3B5RS RN Cannabinoid receptor 2 (CB2) agonists and antagonists: a patent update.Expert Opin Ther Pat. 2016 Jul;26(7):843-56. DM3B5RS RU https://www.ncbi.nlm.nih.gov/pubmed/27215781 DM5GEBH DI DM5GEBH DM5GEBH DN Carboxamide derivative 1 DM5GEBH MI TT6OEDT DM5GEBH MN Cannabinoid receptor 1 (CB1) DM5GEBH MT DTT DM5GEBH MA Antagonist DM5GEBH RN A comprehensive patents review on cannabinoid 1 receptor antagonists as antiobesity agents. Expert Opin Ther Pat. 2015 Oct;25(10):1093-116. DM5GEBH RU https://pubmed.ncbi.nlm.nih.gov/26161824 DM5WMO9 DI DM5WMO9 DM5WMO9 DN Carboxamide derivative 10 DM5WMO9 MI TTG5QB7 DM5WMO9 MN Calpain-2 (CAPN2) DM5WMO9 MT DTT DM5WMO9 MA Inhibitor DM5WMO9 RN An updated patent review of calpain inhibitors (2012 - 2014).Expert Opin Ther Pat. 2015 Jan;25(1):17-31. DM5WMO9 RU https://www.ncbi.nlm.nih.gov/pubmed/25399719 DM1DN94 DI DM1DN94 DM1DN94 DN Carboxamide derivative 11 DM1DN94 MI TTG5QB7 DM1DN94 MN Calpain-2 (CAPN2) DM1DN94 MT DTT DM1DN94 MA Inhibitor DM1DN94 RN An updated patent review of calpain inhibitors (2012 - 2014).Expert Opin Ther Pat. 2015 Jan;25(1):17-31. DM1DN94 RU https://www.ncbi.nlm.nih.gov/pubmed/25399719 DMU5GKC DI DMU5GKC DMU5GKC DN Carboxamide derivative 4 DMU5GKC MI TTPMQSO DMU5GKC MN ALK tyrosine kinase receptor (ALK) DMU5GKC MT DTT DMU5GKC MA Inhibitor DMU5GKC RN RET kinase inhibitors: a review of recent patents (2012-2015).Expert Opin Ther Pat. 2017 Jan;27(1):91-99. DMU5GKC RU https://www.ncbi.nlm.nih.gov/pubmed/27646564 DMU5GKC DI DMU5GKC DMU5GKC DN Carboxamide derivative 4 DMU5GKC MI TTGJCWZ DMU5GKC MN Fms-like tyrosine kinase 3 (FLT-3) DMU5GKC MT DTT DMU5GKC MA Inhibitor DMU5GKC RN RET kinase inhibitors: a review of recent patents (2012-2015).Expert Opin Ther Pat. 2017 Jan;27(1):91-99. DMU5GKC RU https://www.ncbi.nlm.nih.gov/pubmed/27646564 DMU5GKC DI DMU5GKC DMU5GKC DN Carboxamide derivative 4 DMU5GKC MI TT4DXQT DMU5GKC MN Proto-oncogene c-Ret (RET) DMU5GKC MT DTT DMU5GKC MA Inhibitor DMU5GKC RN RET kinase inhibitors: a review of recent patents (2012-2015).Expert Opin Ther Pat. 2017 Jan;27(1):91-99. DMU5GKC RU https://www.ncbi.nlm.nih.gov/pubmed/27646564 DMU5GKC DI DMU5GKC DMU5GKC DN Carboxamide derivative 4 DMU5GKC MI TTSZ6Y3 DMU5GKC MN Proto-oncogene c-Ros (ROS1) DMU5GKC MT DTT DMU5GKC MA Inhibitor DMU5GKC RN RET kinase inhibitors: a review of recent patents (2012-2015).Expert Opin Ther Pat. 2017 Jan;27(1):91-99. DMU5GKC RU https://www.ncbi.nlm.nih.gov/pubmed/27646564 DM149WN DI DM149WN DM149WN DN Carboxamide derivative 5 DM149WN MI TTG5QB7 DM149WN MN Calpain-2 (CAPN2) DM149WN MT DTT DM149WN MA Inhibitor DM149WN RN An updated patent review of calpain inhibitors (2012 - 2014).Expert Opin Ther Pat. 2015 Jan;25(1):17-31. DM149WN RU https://www.ncbi.nlm.nih.gov/pubmed/25399719 DM6GZW4 DI DM6GZW4 DM6GZW4 DN Carboxamide derivative 6 DM6GZW4 MI TTG5QB7 DM6GZW4 MN Calpain-2 (CAPN2) DM6GZW4 MT DTT DM6GZW4 MA Inhibitor DM6GZW4 RN An updated patent review of calpain inhibitors (2012 - 2014).Expert Opin Ther Pat. 2015 Jan;25(1):17-31. DM6GZW4 RU https://www.ncbi.nlm.nih.gov/pubmed/25399719 DM8TQS4 DI DM8TQS4 DM8TQS4 DN Carboxamide derivative 7 DM8TQS4 MI TTG5QB7 DM8TQS4 MN Calpain-2 (CAPN2) DM8TQS4 MT DTT DM8TQS4 MA Inhibitor DM8TQS4 RN An updated patent review of calpain inhibitors (2012 - 2014).Expert Opin Ther Pat. 2015 Jan;25(1):17-31. DM8TQS4 RU https://www.ncbi.nlm.nih.gov/pubmed/25399719 DM6HI34 DI DM6HI34 DM6HI34 DN Carboxamide derivative 8 DM6HI34 MI TTG5QB7 DM6HI34 MN Calpain-2 (CAPN2) DM6HI34 MT DTT DM6HI34 MA Inhibitor DM6HI34 RN An updated patent review of calpain inhibitors (2012 - 2014).Expert Opin Ther Pat. 2015 Jan;25(1):17-31. DM6HI34 RU https://www.ncbi.nlm.nih.gov/pubmed/25399719 DMVISYC DI DMVISYC DMVISYC DN Carboxamide derivative 9 DMVISYC MI TTG5QB7 DMVISYC MN Calpain-2 (CAPN2) DMVISYC MT DTT DMVISYC MA Inhibitor DMVISYC RN An updated patent review of calpain inhibitors (2012 - 2014).Expert Opin Ther Pat. 2015 Jan;25(1):17-31. DMVISYC RU https://www.ncbi.nlm.nih.gov/pubmed/25399719 DM86E2P DI DM86E2P DM86E2P DN Carboxylic acid derivative 1 DM86E2P MI TTYLQ8V DM86E2P MN Prostaglandin E synthase (PTGES) DM86E2P MT DTT DM86E2P MA Inhibitor DM86E2P RN Microsomal prostaglandin E2 synthase-1 inhibitors: a patent review.Expert Opin Ther Pat. 2017 Sep;27(9):1047-1059. DM86E2P RU https://www.ncbi.nlm.nih.gov/pubmed/28627961 DM7INA1 DI DM7INA1 DM7INA1 DN Central azetidine derivative 1 DM7INA1 MI TTHS256 DM7INA1 MN Metabotropic glutamate receptor 5 (mGluR5) DM7INA1 MT DTT DM7INA1 RN mGlu5 negative allosteric modulators: a patent review (2013 - 2016).Expert Opin Ther Pat. 2017 Jun;27(6):691-706. DM7INA1 RU https://www.ncbi.nlm.nih.gov/pubmed/28067079 DM2BLJ6 DI DM2BLJ6 DM2BLJ6 DN Central azetidine derivative 2 DM2BLJ6 MI TTHS256 DM2BLJ6 MN Metabotropic glutamate receptor 5 (mGluR5) DM2BLJ6 MT DTT DM2BLJ6 RN mGlu5 negative allosteric modulators: a patent review (2013 - 2016).Expert Opin Ther Pat. 2017 Jun;27(6):691-706. DM2BLJ6 RU https://www.ncbi.nlm.nih.gov/pubmed/28067079 DMSMBCO DI DMSMBCO DMSMBCO DN Chalcone derivative 1 DMSMBCO MI TT3Z6Y9 DMSMBCO MN Cysteines of Keap1 (KEAP1 Cysteines) DMSMBCO MT DTT DMSMBCO MA Modulator DMSMBCO RN Recent progress in the development of small molecule Nrf2 modulators: a patent review (2012-2016).Expert Opin Ther Pat. 2017 Jul;27(7):763-785. DMSMBCO RU https://www.ncbi.nlm.nih.gov/pubmed/28454500 DMSMBCO DI DMSMBCO DMSMBCO DN Chalcone derivative 1 DMSMBCO MI TTA6ZN2 DMSMBCO MN Nuclear factor erythroid 2-related factor 2 (Nrf2) DMSMBCO MT DTT DMSMBCO MA Activator DMSMBCO RN Recent progress in the development of small molecule Nrf2 modulators: a patent review (2012-2016).Expert Opin Ther Pat. 2017 Jul;27(7):763-785. DMSMBCO RU https://www.ncbi.nlm.nih.gov/pubmed/28454500 DMG84D3 DI DMG84D3 DMG84D3 DN Chalcone derivative 2 DMG84D3 MI TT3Z6Y9 DMG84D3 MN Cysteines of Keap1 (KEAP1 Cysteines) DMG84D3 MT DTT DMG84D3 MA Modulator DMG84D3 RN Recent progress in the development of small molecule Nrf2 modulators: a patent review (2012-2016).Expert Opin Ther Pat. 2017 Jul;27(7):763-785. DMG84D3 RU https://www.ncbi.nlm.nih.gov/pubmed/28454500 DMG84D3 DI DMG84D3 DMG84D3 DN Chalcone derivative 2 DMG84D3 MI TTA6ZN2 DMG84D3 MN Nuclear factor erythroid 2-related factor 2 (Nrf2) DMG84D3 MT DTT DMG84D3 MA Activator DMG84D3 RN Recent progress in the development of small molecule Nrf2 modulators: a patent review (2012-2016).Expert Opin Ther Pat. 2017 Jul;27(7):763-785. DMG84D3 RU https://www.ncbi.nlm.nih.gov/pubmed/28454500 DMFS7C3 DI DMFS7C3 DMFS7C3 DN Chalcone derivative 3 DMFS7C3 MI TT3Z6Y9 DMFS7C3 MN Cysteines of Keap1 (KEAP1 Cysteines) DMFS7C3 MT DTT DMFS7C3 MA Modulator DMFS7C3 RN Recent progress in the development of small molecule Nrf2 modulators: a patent review (2012-2016).Expert Opin Ther Pat. 2017 Jul;27(7):763-785. DMFS7C3 RU https://www.ncbi.nlm.nih.gov/pubmed/28454500 DMFS7C3 DI DMFS7C3 DMFS7C3 DN Chalcone derivative 3 DMFS7C3 MI TTA6ZN2 DMFS7C3 MN Nuclear factor erythroid 2-related factor 2 (Nrf2) DMFS7C3 MT DTT DMFS7C3 MA Activator DMFS7C3 RN Recent progress in the development of small molecule Nrf2 modulators: a patent review (2012-2016).Expert Opin Ther Pat. 2017 Jul;27(7):763-785. DMFS7C3 RU https://www.ncbi.nlm.nih.gov/pubmed/28454500 DM45COR DI DM45COR DM45COR DN Chalcone derivative 4 DM45COR MI TT3Z6Y9 DM45COR MN Cysteines of Keap1 (KEAP1 Cysteines) DM45COR MT DTT DM45COR MA Modulator DM45COR RN Recent progress in the development of small molecule Nrf2 modulators: a patent review (2012-2016).Expert Opin Ther Pat. 2017 Jul;27(7):763-785. DM45COR RU https://www.ncbi.nlm.nih.gov/pubmed/28454500 DM45COR DI DM45COR DM45COR DN Chalcone derivative 4 DM45COR MI TTA6ZN2 DM45COR MN Nuclear factor erythroid 2-related factor 2 (Nrf2) DM45COR MT DTT DM45COR MA Activator DM45COR RN Recent progress in the development of small molecule Nrf2 modulators: a patent review (2012-2016).Expert Opin Ther Pat. 2017 Jul;27(7):763-785. DM45COR RU https://www.ncbi.nlm.nih.gov/pubmed/28454500 DMJZGT8 DI DMJZGT8 DMJZGT8 DN Chalcone derivative 5 DMJZGT8 MI TT2F4OL DMJZGT8 MN Tissue transglutaminase (TG2) DMJZGT8 MT DTT DMJZGT8 MA Inhibitor DMJZGT8 RN Transglutaminase inhibitors: a patent review.Expert Opin Ther Pat. 2016;26(1):49-63. DMJZGT8 RU https://www.ncbi.nlm.nih.gov/pubmed/26560530 DMB8MNU DI DMB8MNU DMB8MNU DN CHIR-99021 DMB8MNU MI TTH6V3D DMB8MNU MN Cyclin-dependent kinase 1 (CDK1) DMB8MNU MT DTT DMB8MNU MA Inhibitor DMB8MNU RN Selective glycogen synthase kinase 3 inhibitors potentiate insulin activation of glucose transport and utilization in vitro and in vivo. Diabetes. 2003 Mar;52(3):588-95. DMB8MNU RU https://pubmed.ncbi.nlm.nih.gov/12606497 DMB8MNU DI DMB8MNU DMB8MNU DN CHIR-99021 DMB8MNU MI TT4TQBX DMB8MNU MN Extracellular signal-regulated kinase 2 (ERK2) DMB8MNU MT DTT DMB8MNU MA Inhibitor DMB8MNU RN Selective glycogen synthase kinase 3 inhibitors potentiate insulin activation of glucose transport and utilization in vitro and in vivo. Diabetes. 2003 Mar;52(3):588-95. DMB8MNU RU https://pubmed.ncbi.nlm.nih.gov/12606497 DMB8MNU DI DMB8MNU DMB8MNU DN CHIR-99021 DMB8MNU MI TTRZQE3 DMB8MNU MN Glycogen synthase kinase-3 alpha (GSK-3A) DMB8MNU MT DTT DMB8MNU MA Inhibitor DMB8MNU RN Glycogen synthase kinase 3 (GSK-3) inhibitors: a patent update (2014-2015).Expert Opin Ther Pat. 2017 Jun;27(6):657-666. DMB8MNU RU https://www.ncbi.nlm.nih.gov/pubmed/27828716 DMB8MNU DI DMB8MNU DMB8MNU DN CHIR-99021 DMB8MNU MI TTRSMW9 DMB8MNU MN Glycogen synthase kinase-3 beta (GSK-3B) DMB8MNU MT DTT DMB8MNU MA Inhibitor DMB8MNU RN Selective glycogen synthase kinase 3 inhibitors potentiate insulin activation of glucose transport and utilization in vitro and in vivo. Diabetes. 2003 Mar;52(3):588-95. DMB8MNU RU https://pubmed.ncbi.nlm.nih.gov/12606497 DMW4J0P DI DMW4J0P DMW4J0P DN Chloroacetyl ester derivative 1 DMW4J0P MI TT2F4OL DMW4J0P MN Tissue transglutaminase (TG2) DMW4J0P MT DTT DMW4J0P MA Inhibitor DMW4J0P RN Transglutaminase inhibitors: a patent review.Expert Opin Ther Pat. 2016;26(1):49-63. DMW4J0P RU https://www.ncbi.nlm.nih.gov/pubmed/26560530 DMR39ZY DI DMR39ZY DMR39ZY DN Chlorobenzamide derivative 1 DMR39ZY MI TT473XN DMR39ZY MN P2X purinoceptor 7 (P2RX7) DMR39ZY MT DTT DMR39ZY MA Antagonist DMR39ZY RN P2X7 receptor antagonists: a patent review (2010-2015).Expert Opin Ther Pat. 2017 Mar;27(3):257-267. DMR39ZY RU https://www.ncbi.nlm.nih.gov/pubmed/27724045 DMKS7O3 DI DMKS7O3 DMKS7O3 DN Chlorobenzamide derivative 2 DMKS7O3 MI TT473XN DMKS7O3 MN P2X purinoceptor 7 (P2RX7) DMKS7O3 MT DTT DMKS7O3 MA Antagonist DMKS7O3 RN P2X7 receptor antagonists: a patent review (2010-2015).Expert Opin Ther Pat. 2017 Mar;27(3):257-267. DMKS7O3 RU https://www.ncbi.nlm.nih.gov/pubmed/27724045 DM7SOZN DI DM7SOZN DM7SOZN DN Chromene derivative 1 DM7SOZN MI TTWJBZ5 DM7SOZN MN 5-HT 2C receptor (HTR2C) DM7SOZN MT DTT DM7SOZN MA Agonist DM7SOZN RN Novel serotonin receptor 2 (5-HT2R) agonists and antagonists: a patent review (2004-2014).Expert Opin Ther Pat. 2016;26(1):89-106. DM7SOZN RU https://www.ncbi.nlm.nih.gov/pubmed/26609882 DMINXMY DI DMINXMY DMINXMY DN CID 138805970 DMINXMY MI TT3KYWB DMINXMY MN Ribosomal protein S6 kinase alpha-6 (RSK6) DMINXMY MT DTT DMINXMY MA Inhibitor DMINXMY RN Substituted tetrahydropyrido[3,2:4,5]pyrrolo[1,2-a]pyrazine-2-carboxamides as RSK inhibitors. US9771366. DMINXMY RU http://www.freepatentsonline.com/US9771366.html DMITX1G DI DMITX1G DMITX1G DN Citalopram derivative 1 DMITX1G MI TTTIBOJ DMITX1G MN Histamine H1 receptor (H1R) DMITX1G MT DTT DMITX1G MA Inhibitor DMITX1G RN Progress in the development of histamine H3 receptor antagonists/inverse agonists: a patent review (2013-2017).Expert Opin Ther Pat. 2018 Mar;28(3):175-196. DMITX1G RU https://www.ncbi.nlm.nih.gov/pubmed/29334795 DMITX1G DI DMITX1G DMITX1G DN Citalopram derivative 1 DMITX1G MI TT3ROYC DMITX1G MN Serotonin transporter (SERT) DMITX1G MT DTT DMITX1G MA Inhibitor DMITX1G RN Progress in the development of histamine H3 receptor antagonists/inverse agonists: a patent review (2013-2017).Expert Opin Ther Pat. 2018 Mar;28(3):175-196. DMITX1G RU https://www.ncbi.nlm.nih.gov/pubmed/29334795 DMV6H95 DI DMV6H95 DMV6H95 DN C-linked disaccharide biphenyl mannoside derivative 1 DMV6H95 MI TTTCRU2 DMV6H95 MN Bacterial Fimbrin D-mannose adhesin (Bact FimH) DMV6H95 MT DTT DMV6H95 MA Antagonist DMV6H95 RN Mannose-derived FimH antagonists: a promising anti-virulence therapeutic strategy for urinary tract infections and Crohn's disease.Expert Opin Ther Pat. 2016;26(2):175-97. DMV6H95 RU https://www.ncbi.nlm.nih.gov/pubmed/26651364 DMJT1WG DI DMJT1WG DMJT1WG DN C-linked disaccharide biphenyl mannoside derivative 2 DMJT1WG MI TTTCRU2 DMJT1WG MN Bacterial Fimbrin D-mannose adhesin (Bact FimH) DMJT1WG MT DTT DMJT1WG MA Antagonist DMJT1WG RN Mannose-derived FimH antagonists: a promising anti-virulence therapeutic strategy for urinary tract infections and Crohn's disease.Expert Opin Ther Pat. 2016;26(2):175-97. DMJT1WG RU https://www.ncbi.nlm.nih.gov/pubmed/26651364 DMY10T2 DI DMY10T2 DMY10T2 DN C-linked disaccharide biphenyl mannoside derivative 3 DMY10T2 MI TTTCRU2 DMY10T2 MN Bacterial Fimbrin D-mannose adhesin (Bact FimH) DMY10T2 MT DTT DMY10T2 MA Antagonist DMY10T2 RN Mannose-derived FimH antagonists: a promising anti-virulence therapeutic strategy for urinary tract infections and Crohn's disease.Expert Opin Ther Pat. 2016;26(2):175-97. DMY10T2 RU https://www.ncbi.nlm.nih.gov/pubmed/26651364 DMRLE65 DI DMRLE65 DMRLE65 DN C-linked disaccharide biphenyl mannoside derivative 4 DMRLE65 MI TTTCRU2 DMRLE65 MN Bacterial Fimbrin D-mannose adhesin (Bact FimH) DMRLE65 MT DTT DMRLE65 MA Antagonist DMRLE65 RN Mannose-derived FimH antagonists: a promising anti-virulence therapeutic strategy for urinary tract infections and Crohn's disease.Expert Opin Ther Pat. 2016;26(2):175-97. DMRLE65 RU https://www.ncbi.nlm.nih.gov/pubmed/26651364 DMUG7E9 DI DMUG7E9 DMUG7E9 DN C-linked disaccharide biphenyl mannoside derivative 5 DMUG7E9 MI TTTCRU2 DMUG7E9 MN Bacterial Fimbrin D-mannose adhesin (Bact FimH) DMUG7E9 MT DTT DMUG7E9 MA Antagonist DMUG7E9 RN Mannose-derived FimH antagonists: a promising anti-virulence therapeutic strategy for urinary tract infections and Crohn's disease.Expert Opin Ther Pat. 2016;26(2):175-97. DMUG7E9 RU https://www.ncbi.nlm.nih.gov/pubmed/26651364 DMUILMD DI DMUILMD DMUILMD DN C-linked disaccharide biphenyl mannoside derivative 6 DMUILMD MI TTTCRU2 DMUILMD MN Bacterial Fimbrin D-mannose adhesin (Bact FimH) DMUILMD MT DTT DMUILMD MA Antagonist DMUILMD RN Mannose-derived FimH antagonists: a promising anti-virulence therapeutic strategy for urinary tract infections and Crohn's disease.Expert Opin Ther Pat. 2016;26(2):175-97. DMUILMD RU https://www.ncbi.nlm.nih.gov/pubmed/26651364 DMWYJF6 DI DMWYJF6 DMWYJF6 DN Complex heterocyclic compound 1 DMWYJF6 MI TTSCIM2 DMWYJF6 MN Extracellular lysophospholipase D (E-NPP2) DMWYJF6 MT DTT DMWYJF6 MA Inhibitor DMWYJF6 RN Autotaxin inhibitors: a patent review (2012-2016).Expert Opin Ther Pat. 2017 Jul;27(7):815-829. DMWYJF6 RU https://www.ncbi.nlm.nih.gov/pubmed/28447479 DMLZMIG DI DMLZMIG DMLZMIG DN Conjugated 3-(indolyl)-and 3-(azaindolyl)-4-arylmaleimide compound 1 DMLZMIG MI TTOHSBA DMLZMIG MN Vascular endothelial growth factor A (VEGFA) DMLZMIG MT DTT DMLZMIG MA Inhibitor DMLZMIG RN VEGFR-2 inhibitors and the therapeutic applications thereof: a patent review (2012-2016).Expert Opin Ther Pat. 2017 Sep;27(9):987-1004. DMLZMIG RU https://www.ncbi.nlm.nih.gov/pubmed/28621580 DM3ZGBH DI DM3ZGBH DM3ZGBH DN Coumaricacid DM3ZGBH MI TTGP7BY DM3ZGBH MN Monoamine oxidase type B (MAO-B) DM3ZGBH MT DTT DM3ZGBH MA Inhibitor DM3ZGBH RN Novel monoamine oxidase inhibitors: a patent review (2012 - 2014).Expert Opin Ther Pat. 2015 Jan;25(1):91-110. DM3ZGBH RU https://www.ncbi.nlm.nih.gov/pubmed/25399762 DMI1BKA DI DMI1BKA DMI1BKA DN Coumarin/resveratrol hybrid derivative 1 DMI1BKA MI TTGP7BY DMI1BKA MN Monoamine oxidase type B (MAO-B) DMI1BKA MT DTT DMI1BKA MA Inhibitor DMI1BKA RN MAO inhibitors and their wider applications: a patent review.Expert Opin Ther Pat. 2018 Mar;28(3):211-226. DMI1BKA RU https://www.ncbi.nlm.nih.gov/pubmed/29324067 DMK12OT DI DMK12OT DMK12OT DN Coumarin/resveratrol hybrid derivative 2 DMK12OT MI TTGP7BY DMK12OT MN Monoamine oxidase type B (MAO-B) DMK12OT MT DTT DMK12OT MA Inhibitor DMK12OT RN MAO inhibitors and their wider applications: a patent review.Expert Opin Ther Pat. 2018 Mar;28(3):211-226. DMK12OT RU https://www.ncbi.nlm.nih.gov/pubmed/29324067 DMXP073 DI DMXP073 DMXP073 DN CQ7 DMXP073 MI TTV298Y DMXP073 MN Calmodulin-dependent kinase II (CAMKK2) DMXP073 MT DTT DMXP073 MA Inhibitor DMXP073 RN Methods of treating a cancer using substituted pyrrolopyrimidine compounds, compositions thereof. US9623028. DMXP073 RU http://www.freepatentsonline.com/US9623028.html DMBV5Z0 DI DMBV5Z0 DMBV5Z0 DN CRWCYVOHVXAEMF-LBPRGKRZSA-N DMBV5Z0 MI TTOYT5L DMBV5Z0 MN Dipeptidyl-peptidase 7 (DPP7) DMBV5Z0 MT DTT DMBV5Z0 MA Inhibitor DMBV5Z0 RN FAP inhibitors. US9346814. DMBV5Z0 RU http://www.freepatentsonline.com/US9346814.html DM76Q10 DI DM76Q10 DM76Q10 DN Crystalline anhydrous toluene derivative 1 DM76Q10 MI TTZMAO3 DM76Q10 MN Peroxisome proliferator-activated receptor gamma (PPAR-gamma) DM76Q10 MT DTT DM76Q10 MA Agonist DM76Q10 RN PPAR ligands and their therapeutic applications: a patent review (2008 - 2014).Expert Opin Ther Pat. 2015 Feb;25(2):175-91. DM76Q10 RU https://www.ncbi.nlm.nih.gov/pubmed/25416646 DM5BFJO DI DM5BFJO DM5BFJO DN CS-W011402 DM5BFJO MI TT6A59G DM5BFJO MN Phosphodiesterase 4C (PDE4C) DM5BFJO MT DTT DM5BFJO MA Inhibitor DM5BFJO RN Imidazopyridazine compounds. US9598421. DM5BFJO RU http://www.freepatentsonline.com/US9598421.html DM4765M DI DM4765M DM4765M DN Curcumin analog 1 DM4765M MI TTRMX3V DM4765M MN Janus kinase 2 (JAK-2) DM4765M MT DTT DM4765M MA Inhibitor DM4765M RN A STAT inhibitor patent review: progress since 2011.Expert Opin Ther Pat. 2015;25(12):1397-421. DM4765M RU https://www.ncbi.nlm.nih.gov/pubmed/26394986 DM4765M DI DM4765M DM4765M DN Curcumin analog 1 DM4765M MI TTH8FZW DM4765M MN Signal transducer and activator of transcription 3 (STAT3) DM4765M MT DTT DM4765M MA Inhibitor DM4765M RN A STAT inhibitor patent review: progress since 2011.Expert Opin Ther Pat. 2015;25(12):1397-421. DM4765M RU https://www.ncbi.nlm.nih.gov/pubmed/26394986 DMZ8S6X DI DMZ8S6X DMZ8S6X DN Curcumin analog 2 DMZ8S6X MI TTRMX3V DMZ8S6X MN Janus kinase 2 (JAK-2) DMZ8S6X MT DTT DMZ8S6X MA Inhibitor DMZ8S6X RN A STAT inhibitor patent review: progress since 2011.Expert Opin Ther Pat. 2015;25(12):1397-421. DMZ8S6X RU https://www.ncbi.nlm.nih.gov/pubmed/26394986 DMZ8S6X DI DMZ8S6X DMZ8S6X DN Curcumin analog 2 DMZ8S6X MI TTH8FZW DMZ8S6X MN Signal transducer and activator of transcription 3 (STAT3) DMZ8S6X MT DTT DMZ8S6X MA Inhibitor DMZ8S6X RN A STAT inhibitor patent review: progress since 2011.Expert Opin Ther Pat. 2015;25(12):1397-421. DMZ8S6X RU https://www.ncbi.nlm.nih.gov/pubmed/26394986 DMMX1ZE DI DMMX1ZE DMMX1ZE DN Cyano(dimethyl)methyl isoxazoles and [1,3,4]-thiadiazoles derivative 1 DMMX1ZE MI TT6OEDT DMMX1ZE MN Cannabinoid receptor 1 (CB1) DMMX1ZE MT DTT DMMX1ZE MA Agonist DMMX1ZE RN Cannabinoid receptor 2 (CB2) agonists and antagonists: a patent update.Expert Opin Ther Pat. 2016 Jul;26(7):843-56. DMMX1ZE RU https://www.ncbi.nlm.nih.gov/pubmed/27215781 DMMX1ZE DI DMMX1ZE DMMX1ZE DN Cyano(dimethyl)methyl isoxazoles and [1,3,4]-thiadiazoles derivative 1 DMMX1ZE MI TTMSFAW DMMX1ZE MN Cannabinoid receptor 2 (CB2) DMMX1ZE MT DTT DMMX1ZE MA Agonist DMMX1ZE RN Cannabinoid receptor 2 (CB2) agonists and antagonists: a patent update.Expert Opin Ther Pat. 2016 Jul;26(7):843-56. DMMX1ZE RU https://www.ncbi.nlm.nih.gov/pubmed/27215781 DM6GTDM DI DM6GTDM DM6GTDM DN Cyano(dimethyl)methyl isoxazoles and [1,3,4]-thiadiazoles derivative 2 DM6GTDM MI TT6OEDT DM6GTDM MN Cannabinoid receptor 1 (CB1) DM6GTDM MT DTT DM6GTDM MA Agonist DM6GTDM RN Cannabinoid receptor 2 (CB2) agonists and antagonists: a patent update.Expert Opin Ther Pat. 2016 Jul;26(7):843-56. DM6GTDM RU https://www.ncbi.nlm.nih.gov/pubmed/27215781 DM6GTDM DI DM6GTDM DM6GTDM DN Cyano(dimethyl)methyl isoxazoles and [1,3,4]-thiadiazoles derivative 2 DM6GTDM MI TTMSFAW DM6GTDM MN Cannabinoid receptor 2 (CB2) DM6GTDM MT DTT DM6GTDM MA Agonist DM6GTDM RN Cannabinoid receptor 2 (CB2) agonists and antagonists: a patent update.Expert Opin Ther Pat. 2016 Jul;26(7):843-56. DM6GTDM RU https://www.ncbi.nlm.nih.gov/pubmed/27215781 DMD198F DI DMD198F DMD198F DN Cyanomethyl pypazole carboxamide derivative 1 DMD198F MI TT6DM01 DMD198F MN Janus kinase 1 (JAK-1) DMD198F MT DTT DMD198F MA Inhibitor DMD198F RN Inhibitors of JAK-family kinases: an update on the patent literature 2013-2015, part 2.Expert Opin Ther Pat. 2017 Feb;27(2):145-161. 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DMSVMUT RU https://www.ncbi.nlm.nih.gov/pubmed/30107136 DMGRBAJ DI DMGRBAJ DMGRBAJ DN Cyclic compound 2 DMGRBAJ MI TTNBFWK DMGRBAJ MN Programmed cell death protein 1 (PD-1) DMGRBAJ MT DTT DMGRBAJ MA Inhibitor DMGRBAJ RN A patent review on PD-1/PD-L1 antagonists: small molecules, peptides, and macrocycles (2015-2018).Expert Opin Ther Pat. 2018 Sep;28(9):665-678. DMGRBAJ RU https://www.ncbi.nlm.nih.gov/pubmed/30107136 DMVOEN7 DI DMVOEN7 DMVOEN7 DN Cyclic compound 3 DMVOEN7 MI TTNBFWK DMVOEN7 MN Programmed cell death protein 1 (PD-1) DMVOEN7 MT DTT DMVOEN7 MA Inhibitor DMVOEN7 RN A patent review on PD-1/PD-L1 antagonists: small molecules, peptides, and macrocycles (2015-2018).Expert Opin Ther Pat. 2018 Sep;28(9):665-678. DMVOEN7 RU https://www.ncbi.nlm.nih.gov/pubmed/30107136 DM2BZI0 DI DM2BZI0 DM2BZI0 DN Cyclic cyanoethypypazole derivative 1 DM2BZI0 MI TT6DM01 DM2BZI0 MN Janus kinase 1 (JAK-1) DM2BZI0 MT DTT DM2BZI0 MA Inhibitor DM2BZI0 RN Inhibitors of JAK-family kinases: an update on the patent literature 2013-2015, part 2.Expert Opin Ther Pat. 2017 Feb;27(2):145-161. DM2BZI0 RU https://www.ncbi.nlm.nih.gov/pubmed/27774822 DM2BZI0 DI DM2BZI0 DM2BZI0 DN Cyclic cyanoethypypazole derivative 1 DM2BZI0 MI TTRMX3V DM2BZI0 MN Janus kinase 2 (JAK-2) DM2BZI0 MT DTT DM2BZI0 MA Inhibitor DM2BZI0 RN Inhibitors of JAK-family kinases: an update on the patent literature 2013-2015, part 2.Expert Opin Ther Pat. 2017 Feb;27(2):145-161. DM2BZI0 RU https://www.ncbi.nlm.nih.gov/pubmed/27774822 DM0K62M DI DM0K62M DM0K62M DN Cyclic hydroxamate derivative 1 DM0K62M MI TTZJYKH DM0K62M MN Indoleamine 2,3-dioxygenase 1 (IDO1) DM0K62M MT DTT DM0K62M MA Inhibitor DM0K62M RN A patent review of IDO1 inhibitors for cancer.Expert Opin Ther Pat. 2018 Apr;28(4):317-330. DM0K62M RU https://www.ncbi.nlm.nih.gov/pubmed/29473428 DM1ZIPN DI DM1ZIPN DM1ZIPN DN Cyclic octapeptide derivative 1 DM1ZIPN MI TTUX68I DM1ZIPN MN Hypoxia-inducible factor 1 (HIF-1) DM1ZIPN MT DTT DM1ZIPN MA Inhibitor DM1ZIPN RN Hypoxia-inducible factor (HIF) inhibitors: a patent survey (2011-2015).Expert Opin Ther Pat. 2016;26(3):309-22. DM1ZIPN RU https://www.ncbi.nlm.nih.gov/pubmed/26882240 DM78NOU DI DM78NOU DM78NOU DN Cyclic peptide derivative 1 DM78NOU MI TTNR0UQ DM78NOU MN Lysine-specific histone demethylase 1 (LSD) DM78NOU MT DTT DM78NOU MA Inhibitor DM78NOU RN LSD1 inhibitors: a patent review (2010-2015).Expert Opin Ther Pat. 2016 May;26(5):565-80. DM78NOU RU https://www.ncbi.nlm.nih.gov/pubmed/27019002 DM78NOU DI DM78NOU DM78NOU DN Cyclic peptide derivative 1 DM78NOU MI TT3WG5C DM78NOU MN Monoamine oxidase type A (MAO-A) DM78NOU MT DTT DM78NOU MA Inhibitor DM78NOU RN LSD1 inhibitors: a patent review (2010-2015).Expert Opin Ther Pat. 2016 May;26(5):565-80. DM78NOU RU https://www.ncbi.nlm.nih.gov/pubmed/27019002 DM78NOU DI DM78NOU DM78NOU DN Cyclic peptide derivative 1 DM78NOU MI TTGP7BY DM78NOU MN Monoamine oxidase type B (MAO-B) DM78NOU MT DTT DM78NOU MA Inhibitor DM78NOU RN LSD1 inhibitors: a patent review (2010-2015).Expert Opin Ther Pat. 2016 May;26(5):565-80. DM78NOU RU https://www.ncbi.nlm.nih.gov/pubmed/27019002 DMV2UQ5 DI DMV2UQ5 DMV2UQ5 DN Cyclic peptidomimetic derivative 1 DMV2UQ5 MI TT23XQV DMV2UQ5 MN PD-1-PD-L1 interaction (PD-1/PD-L1 PPI) DMV2UQ5 MT DTT DMV2UQ5 MA Inhibitor DMV2UQ5 RN A patent review on PD-1/PD-L1 antagonists: small molecules, peptides, and macrocycles (2015-2018).Expert Opin Ther Pat. 2018 Sep;28(9):665-678. DMV2UQ5 RU https://www.ncbi.nlm.nih.gov/pubmed/30107136 DMWH3FP DI DMWH3FP DMWH3FP DN Cyclic peptidomimetic derivative 2 DMWH3FP MI TT23XQV DMWH3FP MN PD-1-PD-L1 interaction (PD-1/PD-L1 PPI) DMWH3FP MT DTT DMWH3FP MA Inhibitor DMWH3FP RN A patent review on PD-1/PD-L1 antagonists: small molecules, peptides, and macrocycles (2015-2018).Expert Opin Ther Pat. 2018 Sep;28(9):665-678. DMWH3FP RU https://www.ncbi.nlm.nih.gov/pubmed/30107136 DMI7KG4 DI DMI7KG4 DMI7KG4 DN Cyclic peptidomimetic derivative 3 DMI7KG4 MI TT23XQV DMI7KG4 MN PD-1-PD-L1 interaction (PD-1/PD-L1 PPI) DMI7KG4 MT DTT DMI7KG4 MA Inhibitor DMI7KG4 RN A patent review on PD-1/PD-L1 antagonists: small molecules, peptides, and macrocycles (2015-2018).Expert Opin Ther Pat. 2018 Sep;28(9):665-678. DMI7KG4 RU https://www.ncbi.nlm.nih.gov/pubmed/30107136 DMJMWDV DI DMJMWDV DMJMWDV DN Cyclic sulfonamide derivative 1 DMJMWDV MI TT8J1S3 DMJMWDV MN Smoothened homolog (SMO) DMJMWDV MT DTT DMJMWDV MA Inhibitor DMJMWDV RN Hedgehog inhibitors: a patent review (2013 - present).Expert Opin Ther Pat. 2015 May;25(5):549-65. DMJMWDV RU https://www.ncbi.nlm.nih.gov/pubmed/25726713 DMXSZ5B DI DMXSZ5B DMXSZ5B DN Cyclic sulfonamide derivative 2 DMXSZ5B MI TT8J1S3 DMXSZ5B MN Smoothened homolog (SMO) DMXSZ5B MT DTT DMXSZ5B MA Inhibitor DMXSZ5B RN Hedgehog inhibitors: a patent review (2013 - present).Expert Opin Ther Pat. 2015 May;25(5):549-65. DMXSZ5B RU https://www.ncbi.nlm.nih.gov/pubmed/25726713 DMBANT7 DI DMBANT7 DMBANT7 DN Cyclic sulfonamide derivative 3 DMBANT7 MI TT8J1S3 DMBANT7 MN Smoothened homolog (SMO) DMBANT7 MT DTT DMBANT7 MA Inhibitor DMBANT7 RN Hedgehog inhibitors: a patent review (2013 - present).Expert Opin Ther Pat. 2015 May;25(5):549-65. DMBANT7 RU https://www.ncbi.nlm.nih.gov/pubmed/25726713 DMWAU49 DI DMWAU49 DMWAU49 DN Cyclic sulfonamide derivative 4 DMWAU49 MI TT8J1S3 DMWAU49 MN Smoothened homolog (SMO) DMWAU49 MT DTT DMWAU49 MA Inhibitor DMWAU49 RN Hedgehog inhibitors: a patent review (2013 - present).Expert Opin Ther Pat. 2015 May;25(5):549-65. DMWAU49 RU https://www.ncbi.nlm.nih.gov/pubmed/25726713 DMXMGSP DI DMXMGSP DMXMGSP DN Cycloalkyl acid derivative 1 DMXMGSP MI TTA592U DMXMGSP MN Urate anion exchanger 1 (URAT1) DMXMGSP MT DTT DMXMGSP MA Inhibitor DMXMGSP RN Urate transporter URAT1 inhibitors: a patent review (2012 - 2015).Expert Opin Ther Pat. 2016 Jul 30:1-10. DMXMGSP RU https://www.ncbi.nlm.nih.gov/pubmed/27414413 DM09LY3 DI DM09LY3 DM09LY3 DN Cycloalkyl acid derivative 2 DM09LY3 MI TTA592U DM09LY3 MN Urate anion exchanger 1 (URAT1) DM09LY3 MT DTT DM09LY3 MA Inhibitor DM09LY3 RN Urate transporter URAT1 inhibitors: a patent review (2012 - 2015).Expert Opin Ther Pat. 2016 Jul 30:1-10. DM09LY3 RU https://www.ncbi.nlm.nih.gov/pubmed/27414413 DM3RK0S DI DM3RK0S DM3RK0S DN Cycloalkyl nitrile pyrazole carboxamide derivative 1 DM3RK0S MI TT6DM01 DM3RK0S MN Janus kinase 1 (JAK-1) DM3RK0S MT DTT DM3RK0S MA Inhibitor DM3RK0S RN Inhibitors of JAK-family kinases: an update on the patent literature 2013-2015, part 2.Expert Opin Ther Pat. 2017 Feb;27(2):145-161. DM3RK0S RU https://www.ncbi.nlm.nih.gov/pubmed/27774822 DM3RK0S DI DM3RK0S DM3RK0S DN Cycloalkyl nitrile pyrazole carboxamide derivative 1 DM3RK0S MI TTRMX3V DM3RK0S MN Janus kinase 2 (JAK-2) DM3RK0S MT DTT DM3RK0S MA Inhibitor DM3RK0S RN Inhibitors of JAK-family kinases: an update on the patent literature 2013-2015, part 2.Expert Opin Ther Pat. 2017 Feb;27(2):145-161. DM3RK0S RU https://www.ncbi.nlm.nih.gov/pubmed/27774822 DMD3LK1 DI DMD3LK1 DMD3LK1 DN Cycloalkyl nitrile pyrazolo pyridone derivative 1 DMD3LK1 MI TT6DM01 DMD3LK1 MN Janus kinase 1 (JAK-1) DMD3LK1 MT DTT DMD3LK1 MA Inhibitor DMD3LK1 RN Inhibitors of JAK-family kinases: an update on the patent literature 2013-2015, part 2.Expert Opin Ther Pat. 2017 Feb;27(2):145-161. DMD3LK1 RU https://www.ncbi.nlm.nih.gov/pubmed/27774822 DMD3LK1 DI DMD3LK1 DMD3LK1 DN Cycloalkyl nitrile pyrazolo pyridone derivative 1 DMD3LK1 MI TTRMX3V DMD3LK1 MN Janus kinase 2 (JAK-2) DMD3LK1 MT DTT DMD3LK1 MA Inhibitor DMD3LK1 RN Inhibitors of JAK-family kinases: an update on the patent literature 2013-2015, part 2.Expert Opin Ther Pat. 2017 Feb;27(2):145-161. DMD3LK1 RU https://www.ncbi.nlm.nih.gov/pubmed/27774822 DMW4JB0 DI DMW4JB0 DMW4JB0 DN Cycloalkyl nitrile pyrazolo pyridone derivative 2 DMW4JB0 MI TT6DM01 DMW4JB0 MN Janus kinase 1 (JAK-1) DMW4JB0 MT DTT DMW4JB0 MA Inhibitor DMW4JB0 RN Inhibitors of JAK-family kinases: an update on the patent literature 2013-2015, part 2.Expert Opin Ther Pat. 2017 Feb;27(2):145-161. DMW4JB0 RU https://www.ncbi.nlm.nih.gov/pubmed/27774822 DMW4JB0 DI DMW4JB0 DMW4JB0 DN Cycloalkyl nitrile pyrazolo pyridone derivative 2 DMW4JB0 MI TTRMX3V DMW4JB0 MN Janus kinase 2 (JAK-2) DMW4JB0 MT DTT DMW4JB0 MA Inhibitor DMW4JB0 RN Inhibitors of JAK-family kinases: an update on the patent literature 2013-2015, part 2.Expert Opin Ther Pat. 2017 Feb;27(2):145-161. DMW4JB0 RU https://www.ncbi.nlm.nih.gov/pubmed/27774822 DMN3WID DI DMN3WID DMN3WID DN Cyclohexane carboxamide derivative 1 DMN3WID MI TTTJZ4M DMN3WID MN Prolylcarboxypeptidase (PRCP) DMN3WID MT DTT DMN3WID MA Inhibitor DMN3WID RN Prolylcarboxypeptidase (PrCP) inhibitors and the therapeutic uses thereof: a patent review.Expert Opin Ther Pat. 2017 Oct;27(10):1077-1088. DMN3WID RU https://www.ncbi.nlm.nih.gov/pubmed/28699813 DM1A0WU DI DM1A0WU DM1A0WU DN Cyclohexane carboxamide derivative 2 DM1A0WU MI TTTJZ4M DM1A0WU MN Prolylcarboxypeptidase (PRCP) DM1A0WU MT DTT DM1A0WU MA Inhibitor DM1A0WU RN Prolylcarboxypeptidase (PrCP) inhibitors and the therapeutic uses thereof: a patent review.Expert Opin Ther Pat. 2017 Oct;27(10):1077-1088. DM1A0WU RU https://www.ncbi.nlm.nih.gov/pubmed/28699813 DMQLZUW DI DMQLZUW DMQLZUW DN Cyclohexane carboxamide derivative 3 DMQLZUW MI TTTJZ4M DMQLZUW MN Prolylcarboxypeptidase (PRCP) DMQLZUW MT DTT DMQLZUW MA Inhibitor DMQLZUW RN Prolylcarboxypeptidase (PrCP) inhibitors and the therapeutic uses thereof: a patent review.Expert Opin Ther Pat. 2017 Oct;27(10):1077-1088. DMQLZUW RU https://www.ncbi.nlm.nih.gov/pubmed/28699813 DMRBI5X DI DMRBI5X DMRBI5X DN Cyclohexyl azetidine derivative 1 DMRBI5X MI TT6DM01 DMRBI5X MN Janus kinase 1 (JAK-1) DMRBI5X MT DTT DMRBI5X MA Inhibitor DMRBI5X RN Inhibitors of JAK-family kinases: an update on the patent literature 2013-2015, part 1.Expert Opin Ther Pat. 2017 Feb;27(2):127-143. DMRBI5X RU https://www.ncbi.nlm.nih.gov/pubmed/27774824 DMORFPT DI DMORFPT DMORFPT DN Cyclohexyl carbamate derivative 1 DMORFPT MI TTULVH8 DMORFPT MN Tyrosinase (TYR) DMORFPT MT DTT DMORFPT MA Inhibitor DMORFPT RN Tyrosinase inhibitors: a patent review (2011-2015).Expert Opin Ther Pat. 2016;26(3):347-62. DMORFPT RU https://www.ncbi.nlm.nih.gov/pubmed/26815044 DM6VPIR DI DM6VPIR DM6VPIR DN Cyclohexyl carbamate derivative 2 DM6VPIR MI TTULVH8 DM6VPIR MN Tyrosinase (TYR) DM6VPIR MT DTT DM6VPIR MA Inhibitor DM6VPIR RN Tyrosinase inhibitors: a patent review (2011-2015).Expert Opin Ther Pat. 2016;26(3):347-62. DM6VPIR RU https://www.ncbi.nlm.nih.gov/pubmed/26815044 DMVIZTY DI DMVIZTY DMVIZTY DN Cyclohexyl carbamate derivative 3 DMVIZTY MI TTULVH8 DMVIZTY MN Tyrosinase (TYR) DMVIZTY MT DTT DMVIZTY MA Inhibitor DMVIZTY RN Tyrosinase inhibitors: a patent review (2011-2015).Expert Opin Ther Pat. 2016;26(3):347-62. DMVIZTY RU https://www.ncbi.nlm.nih.gov/pubmed/26815044 DMLD49W DI DMLD49W DMLD49W DN Cyclohexyl carbamate derivative 4 DMLD49W MI TTULVH8 DMLD49W MN Tyrosinase (TYR) DMLD49W MT DTT DMLD49W MA Inhibitor DMLD49W RN Tyrosinase inhibitors: a patent review (2011-2015).Expert Opin Ther Pat. 2016;26(3):347-62. DMLD49W RU https://www.ncbi.nlm.nih.gov/pubmed/26815044 DMS68DP DI DMS68DP DMS68DP DN Cyclohexyl carbamate derivative 5 DMS68DP MI TTULVH8 DMS68DP MN Tyrosinase (TYR) DMS68DP MT DTT DMS68DP MA Inhibitor DMS68DP RN Tyrosinase inhibitors: a patent review (2011-2015).Expert Opin Ther Pat. 2016;26(3):347-62. DMS68DP RU https://www.ncbi.nlm.nih.gov/pubmed/26815044 DMSD2TN DI DMSD2TN DMSD2TN DN Cyclohexyl carbamate derivative 6 DMSD2TN MI TTULVH8 DMSD2TN MN Tyrosinase (TYR) DMSD2TN MT DTT DMSD2TN MA Inhibitor DMSD2TN RN Tyrosinase inhibitors: a patent review (2011-2015).Expert Opin Ther Pat. 2016;26(3):347-62. DMSD2TN RU https://www.ncbi.nlm.nih.gov/pubmed/26815044 DM2URPE DI DM2URPE DM2URPE DN Cyclohexyl carbamate derivative 7 DM2URPE MI TTULVH8 DM2URPE MN Tyrosinase (TYR) DM2URPE MT DTT DM2URPE MA Inhibitor DM2URPE RN Tyrosinase inhibitors: a patent review (2011-2015).Expert Opin Ther Pat. 2016;26(3):347-62. DM2URPE RU https://www.ncbi.nlm.nih.gov/pubmed/26815044 DMB9DEO DI DMB9DEO DMB9DEO DN Cyclohexyl carbamate derivative 8 DMB9DEO MI TTULVH8 DMB9DEO MN Tyrosinase (TYR) DMB9DEO MT DTT DMB9DEO MA Inhibitor DMB9DEO RN Tyrosinase inhibitors: a patent review (2011-2015).Expert Opin Ther Pat. 2016;26(3):347-62. DMB9DEO RU https://www.ncbi.nlm.nih.gov/pubmed/26815044 DMI2T1D DI DMI2T1D DMI2T1D DN Cyclohexyl-ethyl-substituted diaza and triaza-tricyclic compound 1 DMI2T1D MI TTZJYKH DMI2T1D MN Indoleamine 2,3-dioxygenase 1 (IDO1) DMI2T1D MT DTT DMI2T1D MA Antagonist DMI2T1D RN A patent review of IDO1 inhibitors for cancer.Expert Opin Ther Pat. 2018 Apr;28(4):317-330. DMI2T1D RU https://www.ncbi.nlm.nih.gov/pubmed/29473428 DMKM6BY DI DMKM6BY DMKM6BY DN Cyclopenta[d]pyrimidine derivative 1 DMKM6BY MI TTKN7QR DMKM6BY MN BDNF/NT-3 growth factors receptor (TrkB) DMKM6BY MT DTT DMKM6BY MA Inhibitor DMKM6BY RN Tropomyosin receptor kinase inhibitors: an updated patent review for 2010-2016 - Part I.Expert Opin Ther Pat. 2017 Jun;27(6):733-751. DMKM6BY RU https://www.ncbi.nlm.nih.gov/pubmed/28270010 DMKM6BY DI DMKM6BY DMKM6BY DN Cyclopenta[d]pyrimidine derivative 1 DMKM6BY MI TTXABCW DMKM6BY MN NT-3 growth factor receptor (TrkC) DMKM6BY MT DTT DMKM6BY MA Inhibitor DMKM6BY RN Tropomyosin receptor kinase inhibitors: an updated patent review for 2010-2016 - Part I.Expert Opin Ther Pat. 2017 Jun;27(6):733-751. DMKM6BY RU https://www.ncbi.nlm.nih.gov/pubmed/28270010 DMH7PGC DI DMH7PGC DMH7PGC DN Cyclopentane carboxamide derivative 1 DMH7PGC MI TTTJZ4M DMH7PGC MN Prolylcarboxypeptidase (PRCP) DMH7PGC MT DTT DMH7PGC MA Inhibitor DMH7PGC RN Prolylcarboxypeptidase (PrCP) inhibitors and the therapeutic uses thereof: a patent review.Expert Opin Ther Pat. 2017 Oct;27(10):1077-1088. DMH7PGC RU https://www.ncbi.nlm.nih.gov/pubmed/28699813 DMYP5FK DI DMYP5FK DMYP5FK DN Cyclopentane carboxamide derivative 2 DMYP5FK MI TTTJZ4M DMYP5FK MN Prolylcarboxypeptidase (PRCP) DMYP5FK MT DTT DMYP5FK MA Inhibitor DMYP5FK RN Prolylcarboxypeptidase (PrCP) inhibitors and the therapeutic uses thereof: a patent review.Expert Opin Ther Pat. 2017 Oct;27(10):1077-1088. DMYP5FK RU https://www.ncbi.nlm.nih.gov/pubmed/28699813 DMNXBPQ DI DMNXBPQ DMNXBPQ DN Cyclopropane 1-carboxylic acid derivative 1 DMNXBPQ MI TTIY56R DMNXBPQ MN Kynurenine 3-hydroxylase (KMO) DMNXBPQ MT DTT DMNXBPQ MA Inhibitor DMNXBPQ RN Inhibitors of the kynurenine pathway as neurotherapeutics: a patent review (2012-2015).Expert Opin Ther Pat. 2016 Jul;26(7):815-32. DMNXBPQ RU https://www.ncbi.nlm.nih.gov/pubmed/27172114 DM3M169 DI DM3M169 DM3M169 DN Cyclopropane 1-carboxylic acid derivative 10 DM3M169 MI TTIY56R DM3M169 MN Kynurenine 3-hydroxylase (KMO) DM3M169 MT DTT DM3M169 MA Inhibitor DM3M169 RN Inhibitors of the kynurenine pathway as neurotherapeutics: a patent review (2012-2015).Expert Opin Ther Pat. 2016 Jul;26(7):815-32. DM3M169 RU https://www.ncbi.nlm.nih.gov/pubmed/27172114 DMSXB58 DI DMSXB58 DMSXB58 DN Cyclopropane 1-carboxylic acid derivative 2 DMSXB58 MI TTIY56R DMSXB58 MN Kynurenine 3-hydroxylase (KMO) DMSXB58 MT DTT DMSXB58 MA Inhibitor DMSXB58 RN Inhibitors of the kynurenine pathway as neurotherapeutics: a patent review (2012-2015).Expert Opin Ther Pat. 2016 Jul;26(7):815-32. DMSXB58 RU https://www.ncbi.nlm.nih.gov/pubmed/27172114 DM6K59I DI DM6K59I DM6K59I DN Cyclopropane 1-carboxylic acid derivative 3 DM6K59I MI TTIY56R DM6K59I MN Kynurenine 3-hydroxylase (KMO) DM6K59I MT DTT DM6K59I MA Inhibitor DM6K59I RN Inhibitors of the kynurenine pathway as neurotherapeutics: a patent review (2012-2015).Expert Opin Ther Pat. 2016 Jul;26(7):815-32. DM6K59I RU https://www.ncbi.nlm.nih.gov/pubmed/27172114 DM8PVN3 DI DM8PVN3 DM8PVN3 DN Cyclopropane 1-carboxylic acid derivative 4 DM8PVN3 MI TTIY56R DM8PVN3 MN Kynurenine 3-hydroxylase (KMO) DM8PVN3 MT DTT DM8PVN3 MA Inhibitor DM8PVN3 RN Inhibitors of the kynurenine pathway as neurotherapeutics: a patent review (2012-2015).Expert Opin Ther Pat. 2016 Jul;26(7):815-32. DM8PVN3 RU https://www.ncbi.nlm.nih.gov/pubmed/27172114 DMCSIYG DI DMCSIYG DMCSIYG DN Cyclopropane 1-carboxylic acid derivative 5 DMCSIYG MI TTIY56R DMCSIYG MN Kynurenine 3-hydroxylase (KMO) DMCSIYG MT DTT DMCSIYG MA Inhibitor DMCSIYG RN Inhibitors of the kynurenine pathway as neurotherapeutics: a patent review (2012-2015).Expert Opin Ther Pat. 2016 Jul;26(7):815-32. DMCSIYG RU https://www.ncbi.nlm.nih.gov/pubmed/27172114 DM0OMBW DI DM0OMBW DM0OMBW DN Cyclopropane 1-carboxylic acid derivative 6 DM0OMBW MI TTIY56R DM0OMBW MN Kynurenine 3-hydroxylase (KMO) DM0OMBW MT DTT DM0OMBW MA Inhibitor DM0OMBW RN Inhibitors of the kynurenine pathway as neurotherapeutics: a patent review (2012-2015).Expert Opin Ther Pat. 2016 Jul;26(7):815-32. DM0OMBW RU https://www.ncbi.nlm.nih.gov/pubmed/27172114 DM4RTMO DI DM4RTMO DM4RTMO DN Cyclopropane 1-carboxylic acid derivative 7 DM4RTMO MI TTIY56R DM4RTMO MN Kynurenine 3-hydroxylase (KMO) DM4RTMO MT DTT DM4RTMO MA Inhibitor DM4RTMO RN Inhibitors of the kynurenine pathway as neurotherapeutics: a patent review (2012-2015).Expert Opin Ther Pat. 2016 Jul;26(7):815-32. DM4RTMO RU https://www.ncbi.nlm.nih.gov/pubmed/27172114 DM4P9HL DI DM4P9HL DM4P9HL DN Cyclopropane 1-carboxylic acid derivative 8 DM4P9HL MI TTIY56R DM4P9HL MN Kynurenine 3-hydroxylase (KMO) DM4P9HL MT DTT DM4P9HL MA Inhibitor DM4P9HL RN Inhibitors of the kynurenine pathway as neurotherapeutics: a patent review (2012-2015).Expert Opin Ther Pat. 2016 Jul;26(7):815-32. DM4P9HL RU https://www.ncbi.nlm.nih.gov/pubmed/27172114 DMLH9AQ DI DMLH9AQ DMLH9AQ DN Cyclopropane 1-carboxylic acid derivative 9 DMLH9AQ MI TTIY56R DMLH9AQ MN Kynurenine 3-hydroxylase (KMO) DMLH9AQ MT DTT DMLH9AQ MA Inhibitor DMLH9AQ RN Inhibitors of the kynurenine pathway as neurotherapeutics: a patent review (2012-2015).Expert Opin Ther Pat. 2016 Jul;26(7):815-32. DMLH9AQ RU https://www.ncbi.nlm.nih.gov/pubmed/27172114 DMXN361 DI DMXN361 DMXN361 DN Cyclopropylamine derivative 1 DMXN361 MI TTNR0UQ DMXN361 MN Lysine-specific histone demethylase 1 (LSD) DMXN361 MT DTT DMXN361 MA Inhibitor DMXN361 RN LSD1 inhibitors: a patent review (2010-2015).Expert Opin Ther Pat. 2016 May;26(5):565-80. DMXN361 RU https://www.ncbi.nlm.nih.gov/pubmed/27019002 DMZ5WN8 DI DMZ5WN8 DMZ5WN8 DN Cyclopropylamine derivative 10 DMZ5WN8 MI TTNR0UQ DMZ5WN8 MN Lysine-specific histone demethylase 1 (LSD) DMZ5WN8 MT DTT DMZ5WN8 MA Inhibitor DMZ5WN8 RN LSD1 inhibitors: a patent review (2010-2015).Expert Opin Ther Pat. 2016 May;26(5):565-80. DMZ5WN8 RU https://www.ncbi.nlm.nih.gov/pubmed/27019002 DMZ5WN8 DI DMZ5WN8 DMZ5WN8 DN Cyclopropylamine derivative 10 DMZ5WN8 MI TT32XQJ DMZ5WN8 MN Monoamine oxidase (MAO) DMZ5WN8 MT DTT DMZ5WN8 MA Inhibitor DMZ5WN8 RN LSD1 inhibitors: a patent review (2010-2015).Expert Opin Ther Pat. 2016 May;26(5):565-80. DMZ5WN8 RU https://www.ncbi.nlm.nih.gov/pubmed/27019002 DMMJ0YN DI DMMJ0YN DMMJ0YN DN Cyclopropylamine derivative 11 DMMJ0YN MI TTNR0UQ DMMJ0YN MN Lysine-specific histone demethylase 1 (LSD) DMMJ0YN MT DTT DMMJ0YN MA Inhibitor DMMJ0YN RN LSD1 inhibitors: a patent review (2010-2015).Expert Opin Ther Pat. 2016 May;26(5):565-80. DMMJ0YN RU https://www.ncbi.nlm.nih.gov/pubmed/27019002 DMMJ0YN DI DMMJ0YN DMMJ0YN DN Cyclopropylamine derivative 11 DMMJ0YN MI TT32XQJ DMMJ0YN MN Monoamine oxidase (MAO) DMMJ0YN MT DTT DMMJ0YN MA Inhibitor DMMJ0YN RN LSD1 inhibitors: a patent review (2010-2015).Expert Opin Ther Pat. 2016 May;26(5):565-80. DMMJ0YN RU https://www.ncbi.nlm.nih.gov/pubmed/27019002 DMV4I0K DI DMV4I0K DMV4I0K DN Cyclopropylamine derivative 12 DMV4I0K MI TTNR0UQ DMV4I0K MN Lysine-specific histone demethylase 1 (LSD) DMV4I0K MT DTT DMV4I0K MA Inhibitor DMV4I0K RN LSD1 inhibitors: a patent review (2010-2015).Expert Opin Ther Pat. 2016 May;26(5):565-80. DMV4I0K RU https://www.ncbi.nlm.nih.gov/pubmed/27019002 DMV4I0K DI DMV4I0K DMV4I0K DN Cyclopropylamine derivative 12 DMV4I0K MI TT32XQJ DMV4I0K MN Monoamine oxidase (MAO) DMV4I0K MT DTT DMV4I0K MA Inhibitor DMV4I0K RN LSD1 inhibitors: a patent review (2010-2015).Expert Opin Ther Pat. 2016 May;26(5):565-80. DMV4I0K RU https://www.ncbi.nlm.nih.gov/pubmed/27019002 DMXNVD4 DI DMXNVD4 DMXNVD4 DN Cyclopropylamine derivative 13 DMXNVD4 MI TTNR0UQ DMXNVD4 MN Lysine-specific histone demethylase 1 (LSD) DMXNVD4 MT DTT DMXNVD4 MA Inhibitor DMXNVD4 RN LSD1 inhibitors: a patent review (2010-2015).Expert Opin Ther Pat. 2016 May;26(5):565-80. DMXNVD4 RU https://www.ncbi.nlm.nih.gov/pubmed/27019002 DMXNVD4 DI DMXNVD4 DMXNVD4 DN Cyclopropylamine derivative 13 DMXNVD4 MI TT32XQJ DMXNVD4 MN Monoamine oxidase (MAO) DMXNVD4 MT DTT DMXNVD4 MA Inhibitor DMXNVD4 RN LSD1 inhibitors: a patent review (2010-2015).Expert Opin Ther Pat. 2016 May;26(5):565-80. DMXNVD4 RU https://www.ncbi.nlm.nih.gov/pubmed/27019002 DM6E9L4 DI DM6E9L4 DM6E9L4 DN Cyclopropylamine derivative 3 DM6E9L4 MI TTNR0UQ DM6E9L4 MN Lysine-specific histone demethylase 1 (LSD) DM6E9L4 MT DTT DM6E9L4 MA Inhibitor DM6E9L4 RN LSD1 inhibitors: a patent review (2010-2015).Expert Opin Ther Pat. 2016 May;26(5):565-80. DM6E9L4 RU https://www.ncbi.nlm.nih.gov/pubmed/27019002 DMOCF4Y DI DMOCF4Y DMOCF4Y DN Cyclopropylamine derivative 4 DMOCF4Y MI TTNR0UQ DMOCF4Y MN Lysine-specific histone demethylase 1 (LSD) DMOCF4Y MT DTT DMOCF4Y MA Inhibitor DMOCF4Y RN LSD1 inhibitors: a patent review (2010-2015).Expert Opin Ther Pat. 2016 May;26(5):565-80. DMOCF4Y RU https://www.ncbi.nlm.nih.gov/pubmed/27019002 DM5BCGD DI DM5BCGD DM5BCGD DN Cyclopropylamine derivative 5 DM5BCGD MI TTNR0UQ DM5BCGD MN Lysine-specific histone demethylase 1 (LSD) DM5BCGD MT DTT DM5BCGD MA Inhibitor DM5BCGD RN LSD1 inhibitors: a patent review (2010-2015).Expert Opin Ther Pat. 2016 May;26(5):565-80. DM5BCGD RU https://www.ncbi.nlm.nih.gov/pubmed/27019002 DMB2RKC DI DMB2RKC DMB2RKC DN Cyclopropylamine derivative 6 DMB2RKC MI TTNR0UQ DMB2RKC MN Lysine-specific histone demethylase 1 (LSD) DMB2RKC MT DTT DMB2RKC MA Inhibitor DMB2RKC RN LSD1 inhibitors: a patent review (2010-2015).Expert Opin Ther Pat. 2016 May;26(5):565-80. DMB2RKC RU https://www.ncbi.nlm.nih.gov/pubmed/27019002 DM3X4PJ DI DM3X4PJ DM3X4PJ DN Cyclopropylamine derivative 7 DM3X4PJ MI TTNR0UQ DM3X4PJ MN Lysine-specific histone demethylase 1 (LSD) DM3X4PJ MT DTT DM3X4PJ MA Inhibitor DM3X4PJ RN LSD1 inhibitors: a patent review (2010-2015).Expert Opin Ther Pat. 2016 May;26(5):565-80. DM3X4PJ RU https://www.ncbi.nlm.nih.gov/pubmed/27019002 DMA89WQ DI DMA89WQ DMA89WQ DN Cyclopropylamine derivative 8 DMA89WQ MI TTNR0UQ DMA89WQ MN Lysine-specific histone demethylase 1 (LSD) DMA89WQ MT DTT DMA89WQ MA Inhibitor DMA89WQ RN LSD1 inhibitors: a patent review (2010-2015).Expert Opin Ther Pat. 2016 May;26(5):565-80. DMA89WQ RU https://www.ncbi.nlm.nih.gov/pubmed/27019002 DMX7YAL DI DMX7YAL DMX7YAL DN Cyclopropylamine derivative 9 DMX7YAL MI TTNR0UQ DMX7YAL MN Lysine-specific histone demethylase 1 (LSD) DMX7YAL MT DTT DMX7YAL MA Inhibitor DMX7YAL RN LSD1 inhibitors: a patent review (2010-2015).Expert Opin Ther Pat. 2016 May;26(5):565-80. DMX7YAL RU https://www.ncbi.nlm.nih.gov/pubmed/27019002 DMX7YAL DI DMX7YAL DMX7YAL DN Cyclopropylamine derivative 9 DMX7YAL MI TT32XQJ DMX7YAL MN Monoamine oxidase (MAO) DMX7YAL MT DTT DMX7YAL MA Inhibitor DMX7YAL RN LSD1 inhibitors: a patent review (2010-2015).Expert Opin Ther Pat. 2016 May;26(5):565-80. DMX7YAL RU https://www.ncbi.nlm.nih.gov/pubmed/27019002 DM0YTGS DI DM0YTGS DM0YTGS DN Cyclopropyl-spiro piperidine derivative 1 DM0YTGS MI TT4G2JS DM0YTGS MN Voltage-gated sodium channel alpha Nav1.7 (SCN9A) DM0YTGS MT DTT DM0YTGS MA Blocker DM0YTGS RN Sodium channel blockers: a patent review (2010 - 2014).Expert Opin Ther Pat. 2015 Mar;25(3):279-90. DM0YTGS RU https://www.ncbi.nlm.nih.gov/pubmed/25539043 DMM0R65 DI DMM0R65 DMM0R65 DN Cyclopropyl-spiro piperidine derivative 2 DMM0R65 MI TT4G2JS DMM0R65 MN Voltage-gated sodium channel alpha Nav1.7 (SCN9A) DMM0R65 MT DTT DMM0R65 MA Blocker DMM0R65 RN Sodium channel blockers: a patent review (2010 - 2014).Expert Opin Ther Pat. 2015 Mar;25(3):279-90. DMM0R65 RU https://www.ncbi.nlm.nih.gov/pubmed/25539043 DM0IZW8 DI DM0IZW8 DM0IZW8 DN Cyclopropyl-spiro piperidine derivative 3 DM0IZW8 MI TT4G2JS DM0IZW8 MN Voltage-gated sodium channel alpha Nav1.7 (SCN9A) DM0IZW8 MT DTT DM0IZW8 MA Blocker DM0IZW8 RN Sodium channel blockers: a patent review (2010 - 2014).Expert Opin Ther Pat. 2015 Mar;25(3):279-90. DM0IZW8 RU https://www.ncbi.nlm.nih.gov/pubmed/25539043 DM2ZWSM DI DM2ZWSM DM2ZWSM DN Cyclopropyl-spiro piperidine derivative 4 DM2ZWSM MI TT4G2JS DM2ZWSM MN Voltage-gated sodium channel alpha Nav1.7 (SCN9A) DM2ZWSM MT DTT DM2ZWSM MA Blocker DM2ZWSM RN Sodium channel blockers: a patent review (2010 - 2014).Expert Opin Ther Pat. 2015 Mar;25(3):279-90. DM2ZWSM RU https://www.ncbi.nlm.nih.gov/pubmed/25539043 DMXKUMJ DI DMXKUMJ DMXKUMJ DN Decyle nelycorine dibromo salt derivative 1 DMXKUMJ MI TT1RS9F DMXKUMJ MN Acetylcholinesterase (AChE) DMXKUMJ MT DTT DMXKUMJ MA Inhibitor DMXKUMJ RN A patent review of butyrylcholinesterase inhibitors and reactivators 2010-2017.Expert Opin Ther Pat. 2018 Jun;28(6):455-465. DMXKUMJ RU https://www.ncbi.nlm.nih.gov/pubmed/29757691 DMXKUMJ DI DMXKUMJ DMXKUMJ DN Decyle nelycorine dibromo salt derivative 1 DMXKUMJ MI TTEB0GD DMXKUMJ MN Cholinesterase (BCHE) DMXKUMJ MT DTT DMXKUMJ MA Inhibitor DMXKUMJ RN A patent review of butyrylcholinesterase inhibitors and reactivators 2010-2017.Expert Opin Ther Pat. 2018 Jun;28(6):455-465. DMXKUMJ RU https://www.ncbi.nlm.nih.gov/pubmed/29757691 DM3Q9OX DI DM3Q9OX DM3Q9OX DN Deuterated 3-cyanoquinoline derivative 1 DM3Q9OX MI TTS7G69 DM3Q9OX MN Fusion protein Bcr-Abl (Bcr-Abl) DM3Q9OX MT DTT DM3Q9OX MA Inhibitor DM3Q9OX RN Bcr-Abl tyrosine kinase inhibitors: a patent review.Expert Opin Ther Pat. 2015 Apr;25(4):397-412. DM3Q9OX RU https://www.ncbi.nlm.nih.gov/pubmed/25656651 DM3Q9OX DI DM3Q9OX DM3Q9OX DN Deuterated 3-cyanoquinoline derivative 1 DM3Q9OX MI TT6PKBN DM3Q9OX MN Proto-oncogene c-Src (SRC) DM3Q9OX MT DTT DM3Q9OX MA Inhibitor DM3Q9OX RN Bcr-Abl tyrosine kinase inhibitors: a patent review.Expert Opin Ther Pat. 2015 Apr;25(4):397-412. DM3Q9OX RU https://www.ncbi.nlm.nih.gov/pubmed/25656651 DM02V5Q DI DM02V5Q DM02V5Q DN Diamidothiazole derivative 1 DM02V5Q MI TTCY4SB DM02V5Q MN Aurora kinase (AURK) DM02V5Q MT DTT DM02V5Q MA Inhibitor DM02V5Q RN Cyclin-dependent kinase inhibitors for cancer therapy: a patent review (2009 - 2014).Expert Opin Ther Pat. 2015;25(9):953-70. DM02V5Q RU https://www.ncbi.nlm.nih.gov/pubmed/26161698 DM02V5Q DI DM02V5Q DM02V5Q DN Diamidothiazole derivative 1 DM02V5Q MI TTTU902 DM02V5Q MN Checkpoint kinase-1 (CHK1) DM02V5Q MT DTT DM02V5Q MA Inhibitor DM02V5Q RN Cyclin-dependent kinase inhibitors for cancer therapy: a patent review (2009 - 2014).Expert Opin Ther Pat. 2015;25(9):953-70. DM02V5Q RU https://www.ncbi.nlm.nih.gov/pubmed/26161698 DM02V5Q DI DM02V5Q DM02V5Q DN Diamidothiazole derivative 1 DM02V5Q MI TT7HF4W DM02V5Q MN Cyclin-dependent kinase 2 (CDK2) DM02V5Q MT DTT DM02V5Q MA Inhibitor DM02V5Q RN Cyclin-dependent kinase inhibitors for cancer therapy: a patent review (2009 - 2014).Expert Opin Ther Pat. 2015;25(9):953-70. DM02V5Q RU https://www.ncbi.nlm.nih.gov/pubmed/26161698 DM02V5Q DI DM02V5Q DM02V5Q DN Diamidothiazole derivative 1 DM02V5Q MI TTIDAPM DM02V5Q MN ERK activator kinase 1 (MEK1) DM02V5Q MT DTT DM02V5Q MA Inhibitor DM02V5Q RN Cyclin-dependent kinase inhibitors for cancer therapy: a patent review (2009 - 2014).Expert Opin Ther Pat. 2015;25(9):953-70. DM02V5Q RU https://www.ncbi.nlm.nih.gov/pubmed/26161698 DMUG69Q DI DMUG69Q DMUG69Q DN Diamine derivative 1 DMUG69Q MI TTULVH8 DMUG69Q MN Tyrosinase (TYR) DMUG69Q MT DTT DMUG69Q MA Inhibitor DMUG69Q RN Tyrosinase inhibitors: a patent review (2011-2015).Expert Opin Ther Pat. 2016;26(3):347-62. DMUG69Q RU https://www.ncbi.nlm.nih.gov/pubmed/26815044 DMQEYTJ DI DMQEYTJ DMQEYTJ DN Diamine derivative 2 DMQEYTJ MI TTULVH8 DMQEYTJ MN Tyrosinase (TYR) DMQEYTJ MT DTT DMQEYTJ MA Inhibitor DMQEYTJ RN Tyrosinase inhibitors: a patent review (2011-2015).Expert Opin Ther Pat. 2016;26(3):347-62. DMQEYTJ RU https://www.ncbi.nlm.nih.gov/pubmed/26815044 DMSYX4U DI DMSYX4U DMSYX4U DN Diamine derivative 3 DMSYX4U MI TTULVH8 DMSYX4U MN Tyrosinase (TYR) DMSYX4U MT DTT DMSYX4U MA Inhibitor DMSYX4U RN Tyrosinase inhibitors: a patent review (2011-2015).Expert Opin Ther Pat. 2016;26(3):347-62. DMSYX4U RU https://www.ncbi.nlm.nih.gov/pubmed/26815044 DMPUH4Z DI DMPUH4Z DMPUH4Z DN Diaminopyridine analog 4 DMPUH4Z MI TTKFVXR DMPUH4Z MN Renal carcinoma antigen NY-REN-64 (IRAK-4) DMPUH4Z MT DTT DMPUH4Z MA Inhibitor DMPUH4Z RN Inhibitors of interleukin-1 receptor-associated kinase 4 (IRAK4): a patent review (2012-2015).Expert Opin Ther Pat. 2016 Aug;26(8):917-32. DMPUH4Z RU https://www.ncbi.nlm.nih.gov/pubmed/27310003 DM5B0F3 DI DM5B0F3 DM5B0F3 DN Diaminopyridine analog 5 DM5B0F3 MI TTKFVXR DM5B0F3 MN Renal carcinoma antigen NY-REN-64 (IRAK-4) DM5B0F3 MT DTT DM5B0F3 MA Inhibitor DM5B0F3 RN Inhibitors of interleukin-1 receptor-associated kinase 4 (IRAK4): a patent review (2012-2015).Expert Opin Ther Pat. 2016 Aug;26(8):917-32. DM5B0F3 RU https://www.ncbi.nlm.nih.gov/pubmed/27310003 DM06MJH DI DM06MJH DM06MJH DN Diaryl amine derivative 1 DM06MJH MI TT7HF4W DM06MJH MN Cyclin-dependent kinase 2 (CDK2) DM06MJH MT DTT DM06MJH MA Inhibitor DM06MJH RN Cyclin-dependent kinase inhibitors for cancer therapy: a patent review (2009 - 2014).Expert Opin Ther Pat. 2015;25(9):953-70. DM06MJH RU https://www.ncbi.nlm.nih.gov/pubmed/26161698 DM06MJH DI DM06MJH DM06MJH DN Diaryl amine derivative 1 DM06MJH MI TT1LVF2 DM06MJH MN Cyclin-dependent kinase 9 (CDK9) DM06MJH MT DTT DM06MJH MA Inhibitor DM06MJH RN Cyclin-dependent kinase inhibitors for cancer therapy: a patent review (2009 - 2014).Expert Opin Ther Pat. 2015;25(9):953-70. DM06MJH RU https://www.ncbi.nlm.nih.gov/pubmed/26161698 DMRBYAV DI DMRBYAV DMRBYAV DN Diaryl amine derivative 2 DMRBYAV MI TT6R7JZ DMRBYAV MN Histone deacetylase 1 (HDAC1) DMRBYAV MT DTT DMRBYAV MA Inhibitor DMRBYAV RN Novel histone deacetylase 6 (HDAC6) selective inhibitors: a patent evaluation (WO2014181137).Expert Opin Ther Pat. 2017 Mar;27(3):229-236. DMRBYAV RU https://www.ncbi.nlm.nih.gov/pubmed/28092474 DMRBYAV DI DMRBYAV DMRBYAV DN Diaryl amine derivative 2 DMRBYAV MI TT5ZKDI DMRBYAV MN Histone deacetylase 6 (HDAC6) DMRBYAV MT DTT DMRBYAV MA Inhibitor DMRBYAV RN Novel histone deacetylase 6 (HDAC6) selective inhibitors: a patent evaluation (WO2014181137).Expert Opin Ther Pat. 2017 Mar;27(3):229-236. DMRBYAV RU https://www.ncbi.nlm.nih.gov/pubmed/28092474 DMLBN1T DI DMLBN1T DMLBN1T DN Diaryl amine derivative 3 DMLBN1T MI TT6R7JZ DMLBN1T MN Histone deacetylase 1 (HDAC1) DMLBN1T MT DTT DMLBN1T MA Inhibitor DMLBN1T RN Novel histone deacetylase 6 (HDAC6) selective inhibitors: a patent evaluation (WO2014181137).Expert Opin Ther Pat. 2017 Mar;27(3):229-236. DMLBN1T RU https://www.ncbi.nlm.nih.gov/pubmed/28092474 DMLBN1T DI DMLBN1T DMLBN1T DN Diaryl amine derivative 3 DMLBN1T MI TT5ZKDI DMLBN1T MN Histone deacetylase 6 (HDAC6) DMLBN1T MT DTT DMLBN1T MA Inhibitor DMLBN1T RN Novel histone deacetylase 6 (HDAC6) selective inhibitors: a patent evaluation (WO2014181137).Expert Opin Ther Pat. 2017 Mar;27(3):229-236. DMLBN1T RU https://www.ncbi.nlm.nih.gov/pubmed/28092474 DMZL6AX DI DMZL6AX DMZL6AX DN Diaryl amine derivative 4 DMZL6AX MI TT4YWTO DMZL6AX MN Histone deacetylase 3 (HDAC3) DMZL6AX MT DTT DMZL6AX MA Inhibitor DMZL6AX RN Novel histone deacetylase 6 (HDAC6) selective inhibitors: a patent evaluation (WO2014181137).Expert Opin Ther Pat. 2017 Mar;27(3):229-236. DMZL6AX RU https://www.ncbi.nlm.nih.gov/pubmed/28092474 DMZL6AX DI DMZL6AX DMZL6AX DN Diaryl amine derivative 4 DMZL6AX MI TT5ZKDI DMZL6AX MN Histone deacetylase 6 (HDAC6) DMZL6AX MT DTT DMZL6AX MA Inhibitor DMZL6AX RN Novel histone deacetylase 6 (HDAC6) selective inhibitors: a patent evaluation (WO2014181137).Expert Opin Ther Pat. 2017 Mar;27(3):229-236. DMZL6AX RU https://www.ncbi.nlm.nih.gov/pubmed/28092474 DMIQOY7 DI DMIQOY7 DMIQOY7 DN Diaryl morpholine derivative 1 DMIQOY7 MI TT6OEDT DMIQOY7 MN Cannabinoid receptor 1 (CB1) DMIQOY7 MT DTT DMIQOY7 MA Antagonist DMIQOY7 RN A comprehensive patents review on cannabinoid 1 receptor antagonists as antiobesity agents. Expert Opin Ther Pat. 2015 Oct;25(10):1093-116. DMIQOY7 RU https://pubmed.ncbi.nlm.nih.gov/26161824 DMERQ7V DI DMERQ7V DMERQ7V DN Diaryl piperazine derivative 1 DMERQ7V MI TT6OEDT DMERQ7V MN Cannabinoid receptor 1 (CB1) DMERQ7V MT DTT DMERQ7V MA Antagonist DMERQ7V RN A comprehensive patents review on cannabinoid 1 receptor antagonists as antiobesity agents. Expert Opin Ther Pat. 2015 Oct;25(10):1093-116. DMERQ7V RU https://pubmed.ncbi.nlm.nih.gov/26161824 DMDOB20 DI DMDOB20 DMDOB20 DN Diaryl piperazine derivative 2 DMDOB20 MI TT6OEDT DMDOB20 MN Cannabinoid receptor 1 (CB1) DMDOB20 MT DTT DMDOB20 MA Antagonist DMDOB20 RN A comprehensive patents review on cannabinoid 1 receptor antagonists as antiobesity agents. Expert Opin Ther Pat. 2015 Oct;25(10):1093-116. DMDOB20 RU https://pubmed.ncbi.nlm.nih.gov/26161824 DMXFNOD DI DMXFNOD DMXFNOD DN Diarylamine and arylheteroarylamine pyrazole derivative 1 DMXFNOD MI TTJQOD7 DMXFNOD MN 5-HT 2A receptor (HTR2A) DMXFNOD MT DTT DMXFNOD MA Agonist DMXFNOD RN Novel serotonin receptor 2 (5-HT2R) agonists and antagonists: a patent review (2004-2014).Expert Opin Ther Pat. 2016;26(1):89-106. DMXFNOD RU https://www.ncbi.nlm.nih.gov/pubmed/26609882 DM6NR9Y DI DM6NR9Y DM6NR9Y DN Diarylamine and arylheteroarylamine pyrazole derivative 2 DM6NR9Y MI TTJQOD7 DM6NR9Y MN 5-HT 2A receptor (HTR2A) DM6NR9Y MT DTT DM6NR9Y MA Agonist DM6NR9Y RN Novel serotonin receptor 2 (5-HT2R) agonists and antagonists: a patent review (2004-2014).Expert Opin Ther Pat. 2016;26(1):89-106. DM6NR9Y RU https://www.ncbi.nlm.nih.gov/pubmed/26609882 DMLZ1UB DI DMLZ1UB DMLZ1UB DN Diarylamine and arylheteroarylamine pyrazole derivative 3 DMLZ1UB MI TTJQOD7 DMLZ1UB MN 5-HT 2A receptor (HTR2A) DMLZ1UB MT DTT DMLZ1UB MA Agonist DMLZ1UB RN Novel serotonin receptor 2 (5-HT2R) agonists and antagonists: a patent review (2004-2014).Expert Opin Ther Pat. 2016;26(1):89-106. DMLZ1UB RU https://www.ncbi.nlm.nih.gov/pubmed/26609882 DM9YD0Q DI DM9YD0Q DM9YD0Q DN Diazepinone derivative 1 DM9YD0Q MI TTHS256 DM9YD0Q MN Metabotropic glutamate receptor 5 (mGluR5) DM9YD0Q MT DTT DM9YD0Q MA Modulator DM9YD0Q RN mGlu5 negative allosteric modulators: a patent review (2013 - 2016).Expert Opin Ther Pat. 2017 Jun;27(6):691-706. DM9YD0Q RU https://www.ncbi.nlm.nih.gov/pubmed/28067079 DMLQ7PG DI DMLQ7PG DMLQ7PG DN Diazepinone derivative 2 DMLQ7PG MI TTHS256 DMLQ7PG MN Metabotropic glutamate receptor 5 (mGluR5) DMLQ7PG MT DTT DMLQ7PG MA Modulator DMLQ7PG RN mGlu5 negative allosteric modulators: a patent review (2013 - 2016).Expert Opin Ther Pat. 2017 Jun;27(6):691-706. DMLQ7PG RU https://www.ncbi.nlm.nih.gov/pubmed/28067079 DMPTZ69 DI DMPTZ69 DMPTZ69 DN Diazepinone derivative 3 DMPTZ69 MI TTHS256 DMPTZ69 MN Metabotropic glutamate receptor 5 (mGluR5) DMPTZ69 MT DTT DMPTZ69 MA Modulator DMPTZ69 RN mGlu5 negative allosteric modulators: a patent review (2013 - 2016).Expert Opin Ther Pat. 2017 Jun;27(6):691-706. DMPTZ69 RU https://www.ncbi.nlm.nih.gov/pubmed/28067079 DM389YD DI DM389YD DM389YD DN Diazepinone derivative 4 DM389YD MI TTHS256 DM389YD MN Metabotropic glutamate receptor 5 (mGluR5) DM389YD MT DTT DM389YD MA Modulator DM389YD RN mGlu5 negative allosteric modulators: a patent review (2013 - 2016).Expert Opin Ther Pat. 2017 Jun;27(6):691-706. DM389YD RU https://www.ncbi.nlm.nih.gov/pubmed/28067079 DM2U1QH DI DM2U1QH DM2U1QH DN Diazepinone derivative 5 DM2U1QH MI TTHS256 DM2U1QH MN Metabotropic glutamate receptor 5 (mGluR5) DM2U1QH MT DTT DM2U1QH MA Modulator DM2U1QH RN mGlu5 negative allosteric modulators: a patent review (2013 - 2016).Expert Opin Ther Pat. 2017 Jun;27(6):691-706. DM2U1QH RU https://www.ncbi.nlm.nih.gov/pubmed/28067079 DMRM5I1 DI DMRM5I1 DMRM5I1 DN Dibenzo [c,f]-[2,7]naphthyridine derivative 1 DMRM5I1 MI TTCZOF2 DMRM5I1 MN Pyruvate dehydrogenase kinase 1 (PDHK1) DMRM5I1 MT DTT DMRM5I1 MA Inhibitor DMRM5I1 RN PDK1 disruptors and modulators: a patent review.Expert Opin Ther Pat. 2015 May;25(5):513-37. DMRM5I1 RU https://www.ncbi.nlm.nih.gov/pubmed/25684022 DMUNFAT DI DMUNFAT DMUNFAT DN Dihydrobenzoxazine and tetrahydroquinoxaline sulfonamide derivative 1 DMUNFAT MI TTZOVE0 DMUNFAT MN Voltage-gated sodium channel alpha Nav1.5 (SCN5A) DMUNFAT MT DTT DMUNFAT MA Blocker DMUNFAT RN Sodium channel blockers: a patent review (2010 - 2014).Expert Opin Ther Pat. 2015 Mar;25(3):279-90. DMUNFAT RU https://www.ncbi.nlm.nih.gov/pubmed/25539043 DMUNFAT DI DMUNFAT DMUNFAT DN Dihydrobenzoxazine and tetrahydroquinoxaline sulfonamide derivative 1 DMUNFAT MI TT4G2JS DMUNFAT MN Voltage-gated sodium channel alpha Nav1.7 (SCN9A) DMUNFAT MT DTT DMUNFAT MA Blocker DMUNFAT RN Sodium channel blockers: a patent review (2010 - 2014).Expert Opin Ther Pat. 2015 Mar;25(3):279-90. DMUNFAT RU https://www.ncbi.nlm.nih.gov/pubmed/25539043 DMC3IN2 DI DMC3IN2 DMC3IN2 DN Dihydrodiazepinocarbazolone derivative 1 DMC3IN2 MI TTVDSZ0 DMC3IN2 MN Poly [ADP-ribose] polymerase 1 (PARP1) DMC3IN2 MT DTT DMC3IN2 MA Inhibitor DMC3IN2 RN PARP inhibitors as antitumor agents: a patent update (2013-2015).Expert Opin Ther Pat. 2017 Mar;27(3):363-382. DMC3IN2 RU https://www.ncbi.nlm.nih.gov/pubmed/27841036 DMC3IN2 DI DMC3IN2 DMC3IN2 DN Dihydrodiazepinocarbazolone derivative 1 DMC3IN2 MI TTQ4V96 DMC3IN2 MN Poly [ADP-ribose] polymerase 2 (PARP2) DMC3IN2 MT DTT DMC3IN2 MA Inhibitor DMC3IN2 RN PARP inhibitors as antitumor agents: a patent update (2013-2015).Expert Opin Ther Pat. 2017 Mar;27(3):363-382. DMC3IN2 RU https://www.ncbi.nlm.nih.gov/pubmed/27841036 DM1R0FJ DI DM1R0FJ DM1R0FJ DN Dihydrodiazepinocarbazolone derivative 2 DM1R0FJ MI TTEBCY8 DM1R0FJ MN Poly [ADP-ribose] polymerase (PARP) DM1R0FJ MT DTT DM1R0FJ MA Inhibitor DM1R0FJ RN PARP inhibitors as antitumor agents: a patent update (2013-2015).Expert Opin Ther Pat. 2017 Mar;27(3):363-382. DM1R0FJ RU https://www.ncbi.nlm.nih.gov/pubmed/27841036 DM5UPGZ DI DM5UPGZ DM5UPGZ DN Dihydroisoquinoline carboxamide analog 1 DM5UPGZ MI TT473XN DM5UPGZ MN P2X purinoceptor 7 (P2RX7) DM5UPGZ MT DTT DM5UPGZ MA Antagonist DM5UPGZ RN P2X7 receptor antagonists: a patent review (2010-2015).Expert Opin Ther Pat. 2017 Mar;27(3):257-267. DM5UPGZ RU https://www.ncbi.nlm.nih.gov/pubmed/27724045 DMQRECT DI DMQRECT DMQRECT DN Dihydroisoxazole derivative 1 DMQRECT MI TT2F4OL DMQRECT MN Tissue transglutaminase (TG2) DMQRECT MT DTT DMQRECT MA Inhibitor DMQRECT RN Transglutaminase inhibitors: a patent review.Expert Opin Ther Pat. 2016;26(1):49-63. DMQRECT RU https://www.ncbi.nlm.nih.gov/pubmed/26560530 DMLTZKX DI DMLTZKX DMLTZKX DN Dihydroisoxazole derivative 2 DMLTZKX MI TT2F4OL DMLTZKX MN Tissue transglutaminase (TG2) DMLTZKX MT DTT DMLTZKX MA Inhibitor DMLTZKX RN Transglutaminase inhibitors: a patent review.Expert Opin Ther Pat. 2016;26(1):49-63. DMLTZKX RU https://www.ncbi.nlm.nih.gov/pubmed/26560530 DM16M4A DI DM16M4A DM16M4A DN Dihydropyridine compound 1 DM16M4A MI TT4DXQT DM16M4A MN Proto-oncogene c-Ret (RET) DM16M4A MT DTT DM16M4A MA Inhibitor DM16M4A RN RET kinase inhibitors: a review of recent patents (2012-2015).Expert Opin Ther Pat. 2017 Jan;27(1):91-99. DM16M4A RU https://www.ncbi.nlm.nih.gov/pubmed/27646564 DM6RGOY DI DM6RGOY DM6RGOY DN Dihydropyridine compound 2 DM6RGOY MI TT4DXQT DM6RGOY MN Proto-oncogene c-Ret (RET) DM6RGOY MT DTT DM6RGOY MA Inhibitor DM6RGOY RN RET kinase inhibitors: a review of recent patents (2012-2015).Expert Opin Ther Pat. 2017 Jan;27(1):91-99. DM6RGOY RU https://www.ncbi.nlm.nih.gov/pubmed/27646564 DMR3AVK DI DMR3AVK DMR3AVK DN Dihydropyridine compound 3 DMR3AVK MI TT4DXQT DMR3AVK MN Proto-oncogene c-Ret (RET) DMR3AVK MT DTT DMR3AVK MA Inhibitor DMR3AVK RN RET kinase inhibitors: a review of recent patents (2012-2015).Expert Opin Ther Pat. 2017 Jan;27(1):91-99. DMR3AVK RU https://www.ncbi.nlm.nih.gov/pubmed/27646564 DMIFZLG DI DMIFZLG DMIFZLG DN Dihydropyridine compound 4 DMIFZLG MI TT4DXQT DMIFZLG MN Proto-oncogene c-Ret (RET) DMIFZLG MT DTT DMIFZLG MA Inhibitor DMIFZLG RN RET kinase inhibitors: a review of recent patents (2012-2015).Expert Opin Ther Pat. 2017 Jan;27(1):91-99. DMIFZLG RU https://www.ncbi.nlm.nih.gov/pubmed/27646564 DMC41TK DI DMC41TK DMC41TK DN Dihydropyridine compound 5 DMC41TK MI TT4DXQT DMC41TK MN Proto-oncogene c-Ret (RET) DMC41TK MT DTT DMC41TK MA Inhibitor DMC41TK RN RET kinase inhibitors: a review of recent patents (2012-2015).Expert Opin Ther Pat. 2017 Jan;27(1):91-99. DMC41TK RU https://www.ncbi.nlm.nih.gov/pubmed/27646564 DMEXT6J DI DMEXT6J DMEXT6J DN Dihydropyridine compound 6 DMEXT6J MI TT4DXQT DMEXT6J MN Proto-oncogene c-Ret (RET) DMEXT6J MT DTT DMEXT6J MA Inhibitor DMEXT6J RN RET kinase inhibitors: a review of recent patents (2012-2015).Expert Opin Ther Pat. 2017 Jan;27(1):91-99. DMEXT6J RU https://www.ncbi.nlm.nih.gov/pubmed/27646564 DMWIYFQ DI DMWIYFQ DMWIYFQ DN Dihydropyrido phthalazinone derivative 1 DMWIYFQ MI TTVDSZ0 DMWIYFQ MN Poly [ADP-ribose] polymerase 1 (PARP1) DMWIYFQ MT DTT DMWIYFQ MA Inhibitor DMWIYFQ RN PARP inhibitors as antitumor agents: a patent update (2013-2015).Expert Opin Ther Pat. 2017 Mar;27(3):363-382. DMWIYFQ RU https://www.ncbi.nlm.nih.gov/pubmed/27841036 DMR4PQN DI DMR4PQN DMR4PQN DN Dihydropyrido phthalazinone derivative 2 DMR4PQN MI TTVDSZ0 DMR4PQN MN Poly [ADP-ribose] polymerase 1 (PARP1) DMR4PQN MT DTT DMR4PQN MA Inhibitor DMR4PQN RN PARP inhibitors as antitumor agents: a patent update (2013-2015).Expert Opin Ther Pat. 2017 Mar;27(3):363-382. DMR4PQN RU https://www.ncbi.nlm.nih.gov/pubmed/27841036 DMMFBI3 DI DMMFBI3 DMMFBI3 DN Dihydropyrido phthalazinone derivative 3 DMMFBI3 MI TTEBCY8 DMMFBI3 MN Poly [ADP-ribose] polymerase (PARP) DMMFBI3 MT DTT DMMFBI3 MA Inhibitor DMMFBI3 RN PARP inhibitors as antitumor agents: a patent update (2013-2015).Expert Opin Ther Pat. 2017 Mar;27(3):363-382. DMMFBI3 RU https://www.ncbi.nlm.nih.gov/pubmed/27841036 DMWEJ6U DI DMWEJ6U DMWEJ6U DN Dihydropyrido phthalazinone derivative 4 DMWEJ6U MI TTEBCY8 DMWEJ6U MN Poly [ADP-ribose] polymerase (PARP) DMWEJ6U MT DTT DMWEJ6U MA Inhibitor DMWEJ6U RN PARP inhibitors as antitumor agents: a patent update (2013-2015).Expert Opin Ther Pat. 2017 Mar;27(3):363-382. DMWEJ6U RU https://www.ncbi.nlm.nih.gov/pubmed/27841036 DM8S7NQ DI DM8S7NQ DM8S7NQ DN Dihydropyrido pyrazinone compound 1 DM8S7NQ MI TTE4BSY DM8S7NQ MN Bromodomain and extraterminal domain protein (BET) DM8S7NQ MT DTT DM8S7NQ MA Inhibitor DM8S7NQ RN BET inhibitors in cancer therapeutics: a patent review.Expert Opin Ther Pat. 2016;26(4):505-22. DM8S7NQ RU https://www.ncbi.nlm.nih.gov/pubmed/26924192 DMOTG2Y DI DMOTG2Y DMOTG2Y DN Dihydropyrido pyrazinone compound 2 DMOTG2Y MI TTIYVQP DMOTG2Y MN Polo-like kinase 1 (PLK1) DMOTG2Y MT DTT DMOTG2Y MA Inhibitor DMOTG2Y RN BET inhibitors in cancer therapeutics: a patent review.Expert Opin Ther Pat. 2016;26(4):505-22. DMOTG2Y RU https://www.ncbi.nlm.nih.gov/pubmed/26924192 DM3PEUN DI DM3PEUN DM3PEUN DN Dihydropyrido pyrazinone compound 3 DM3PEUN MI TTIYVQP DM3PEUN MN Polo-like kinase 1 (PLK1) DM3PEUN MT DTT DM3PEUN MA Inhibitor DM3PEUN RN BET inhibitors in cancer therapeutics: a patent review.Expert Opin Ther Pat. 2016;26(4):505-22. DM3PEUN RU https://www.ncbi.nlm.nih.gov/pubmed/26924192 DMSTC9Z DI DMSTC9Z DMSTC9Z DN Dihydropyrido pyrimidine derivative 1 DMSTC9Z MI TTSCIM2 DMSTC9Z MN Extracellular lysophospholipase D (E-NPP2) DMSTC9Z MT DTT DMSTC9Z MA Inhibitor DMSTC9Z RN Autotaxin inhibitors: a patent review (2012-2016).Expert Opin Ther Pat. 2017 Jul;27(7):815-829. DMSTC9Z RU https://www.ncbi.nlm.nih.gov/pubmed/28447479 DMA25XH DI DMA25XH DMA25XH DN Dihydropyrimidinone derivative 1 DMA25XH MI TTPLTSQ DMA25XH MN Neutrophil elastase (NE) DMA25XH MT DTT DMA25XH MA Inhibitor DMA25XH RN Neutrophil elastase inhibitors: a patent review and potential applications for inflammatory lung diseases (2010 - 2014).Expert Opin Ther Pat. 2015;25(10):1145-58. DMA25XH RU https://www.ncbi.nlm.nih.gov/pubmed/26118988 DM5Y13R DI DM5Y13R DM5Y13R DN Dihydropyrimidinone derivative 2 DM5Y13R MI TTPLTSQ DM5Y13R MN Neutrophil elastase (NE) DM5Y13R MT DTT DM5Y13R MA Inhibitor DM5Y13R RN Neutrophil elastase inhibitors: a patent review and potential applications for inflammatory lung diseases (2010 - 2014).Expert Opin Ther Pat. 2015;25(10):1145-58. DM5Y13R RU https://www.ncbi.nlm.nih.gov/pubmed/26118988 DMA1S6Q DI DMA1S6Q DMA1S6Q DN Dihydropyrimidinone derivative 3 DMA1S6Q MI TTJOW1I DMA1S6Q MN Mannoside acetylglucosaminyltransferase 2 (MGAT2) DMA1S6Q MT DTT DMA1S6Q MA Inhibitor DMA1S6Q RN Acyltransferase inhibitors: a patent review (2010-present).Expert Opin Ther Pat. 2015 Feb;25(2):145-58. DMA1S6Q RU https://www.ncbi.nlm.nih.gov/pubmed/25470667 DMNEKOZ DI DMNEKOZ DMNEKOZ DN Dihydropyrimidinone derivative 4 DMNEKOZ MI TTJOW1I DMNEKOZ MN Mannoside acetylglucosaminyltransferase 2 (MGAT2) DMNEKOZ MT DTT DMNEKOZ MA Inhibitor DMNEKOZ RN Acyltransferase inhibitors: a patent review (2010-present).Expert Opin Ther Pat. 2015 Feb;25(2):145-58. DMNEKOZ RU https://www.ncbi.nlm.nih.gov/pubmed/25470667 DMHGE1T DI DMHGE1T DMHGE1T DN Dihydropyrrolopyrazole derivative 1 DMHGE1T MI TTDIGC1 DMHGE1T MN Dipeptidyl peptidase 4 (DPP-4) DMHGE1T MT DTT DMHGE1T MA Inhibitor DMHGE1T RN DPP-4 inhibitors: a patent review (2012 - 2014).Expert Opin Ther Pat. 2015 Feb;25(2):209-36. DMHGE1T RU https://www.ncbi.nlm.nih.gov/pubmed/25482888 DMUJ3XK DI DMUJ3XK DMUJ3XK DN Dihydrothieno [2,3-e]indazole derivative 1 DMUJ3XK MI TTRPDBG DMUJ3XK MN Inhibitor of nuclear factor kappa-B kinase (IKK) DMUJ3XK MT DTT DMUJ3XK MA Inhibitor DMUJ3XK RN Novel NF-B inhibitors: a patent review (2011 - 2014).Expert Opin Ther Pat. 2015 Mar;25(3):319-34. DMUJ3XK RU https://www.ncbi.nlm.nih.gov/pubmed/25553724 DM0D3HU DI DM0D3HU DM0D3HU DN Dihydrothieno [2,3-e]indazole derivative 2 DM0D3HU MI TTRPDBG DM0D3HU MN Inhibitor of nuclear factor kappa-B kinase (IKK) DM0D3HU MT DTT DM0D3HU MA Inhibitor DM0D3HU RN Novel NF-B inhibitors: a patent review (2011 - 2014).Expert Opin Ther Pat. 2015 Mar;25(3):319-34. DM0D3HU RU https://www.ncbi.nlm.nih.gov/pubmed/25553724 DM85VQR DI DM85VQR DM85VQR DN Dihydrothieno [2,3-e]indazole derivative 3 DM85VQR MI TTRPDBG DM85VQR MN Inhibitor of nuclear factor kappa-B kinase (IKK) DM85VQR MT DTT DM85VQR MA Inhibitor DM85VQR RN Novel NF-B inhibitors: a patent review (2011 - 2014).Expert Opin Ther Pat. 2015 Mar;25(3):319-34. DM85VQR RU https://www.ncbi.nlm.nih.gov/pubmed/25553724 DMR4LPO DI DMR4LPO DMR4LPO DN Dihydrothieno [2,3-e]indazole derivative 4 DMR4LPO MI TTRPDBG DMR4LPO MN Inhibitor of nuclear factor kappa-B kinase (IKK) DMR4LPO MT DTT DMR4LPO MA Inhibitor DMR4LPO RN Novel NF-B inhibitors: a patent review (2011 - 2014).Expert Opin Ther Pat. 2015 Mar;25(3):319-34. DMR4LPO RU https://www.ncbi.nlm.nih.gov/pubmed/25553724 DMAH1EP DI DMAH1EP DMAH1EP DN Dihydroxyfumaric acid derivative 1 DMAH1EP MI TTULVH8 DMAH1EP MN Tyrosinase (TYR) DMAH1EP MT DTT DMAH1EP MA Inhibitor DMAH1EP RN Tyrosinase inhibitors: a patent review (2011-2015).Expert Opin Ther Pat. 2016;26(3):347-62. DMAH1EP RU https://www.ncbi.nlm.nih.gov/pubmed/26815044 DMZ4B3W DI DMZ4B3W DMZ4B3W DN Dimethoxybenzylidene-2-thio-imidazole-4-one derivative 1 DMZ4B3W MI TTF2LRI DMZ4B3W MN Cathepsin B (CTSB) DMZ4B3W MT DTT DMZ4B3W MA Inhibitor DMZ4B3W RN Cathepsin B and L inhibitors: a patent review (2010 - present).Expert Opin Ther Pat. 2017 Jun;27(6):643-656. DMZ4B3W RU https://www.ncbi.nlm.nih.gov/pubmed/27998201 DM2OTJS DI DM2OTJS DM2OTJS DN Dipeptide analog 1 DM2OTJS MI TTEAD9J DM2OTJS MN Proteasome beta-8 (PS beta-8) DM2OTJS MT DTT DM2OTJS MA Inhibitor DM2OTJS RN A patent review of immunoproteasome inhibitors.Expert Opin Ther Pat. 2018 Jul;28(7):517-540. DM2OTJS RU https://www.ncbi.nlm.nih.gov/pubmed/29865878 DM2OTJS DI DM2OTJS DM2OTJS DN Dipeptide analog 1 DM2OTJS MI TTOUSTQ DM2OTJS MN Proteasome beta-9 (PS beta-9) DM2OTJS MT DTT DM2OTJS MA Inhibitor DM2OTJS RN A patent review of immunoproteasome inhibitors.Expert Opin Ther Pat. 2018 Jul;28(7):517-540. DM2OTJS RU https://www.ncbi.nlm.nih.gov/pubmed/29865878 DMMAF2S DI DMMAF2S DMMAF2S DN Dipeptide analog 2 DMMAF2S MI TT2F4OL DMMAF2S MN Tissue transglutaminase (TG2) DMMAF2S MT DTT DMMAF2S MA Inhibitor DMMAF2S RN Transglutaminase inhibitors: a patent review.Expert Opin Ther Pat. 2016;26(1):49-63. DMMAF2S RU https://www.ncbi.nlm.nih.gov/pubmed/26560530 DM6RLTV DI DM6RLTV DM6RLTV DN Dipeptide analog 3 DM6RLTV MI TT2F4OL DM6RLTV MN Tissue transglutaminase (TG2) DM6RLTV MT DTT DM6RLTV MA Inhibitor DM6RLTV RN Transglutaminase inhibitors: a patent review.Expert Opin Ther Pat. 2016;26(1):49-63. DM6RLTV RU https://www.ncbi.nlm.nih.gov/pubmed/26560530 DMXOPIJ DI DMXOPIJ DMXOPIJ DN Dipeptide analog 4 DMXOPIJ MI TT2F4OL DMXOPIJ MN Tissue transglutaminase (TG2) DMXOPIJ MT DTT DMXOPIJ MA Inhibitor DMXOPIJ RN Transglutaminase inhibitors: a patent review.Expert Opin Ther Pat. 2016;26(1):49-63. DMXOPIJ RU https://www.ncbi.nlm.nih.gov/pubmed/26560530 DM2DYMS DI DM2DYMS DM2DYMS DN Diphenyl purine derivative 1 DM2DYMS MI TT6OEDT DM2DYMS MN Cannabinoid receptor 1 (CB1) DM2DYMS MT DTT DM2DYMS MA Antagonist DM2DYMS RN A comprehensive patents review on cannabinoid 1 receptor antagonists as antiobesity agents. Expert Opin Ther Pat. 2015 Oct;25(10):1093-116. DM2DYMS RU https://pubmed.ncbi.nlm.nih.gov/26161824 DMG8MCJ DI DMG8MCJ DMG8MCJ DN Diphenyl purine derivative 2 DMG8MCJ MI TT6OEDT DMG8MCJ MN Cannabinoid receptor 1 (CB1) DMG8MCJ MT DTT DMG8MCJ MA Antagonist DMG8MCJ RN A comprehensive patents review on cannabinoid 1 receptor antagonists as antiobesity agents. Expert Opin Ther Pat. 2015 Oct;25(10):1093-116. DMG8MCJ RU https://pubmed.ncbi.nlm.nih.gov/26161824 DMY5CFW DI DMY5CFW DMY5CFW DN Diphenyl purine derivative 3 DMY5CFW MI TT6OEDT DMY5CFW MN Cannabinoid receptor 1 (CB1) DMY5CFW MT DTT DMY5CFW MA Antagonist DMY5CFW RN A comprehensive patents review on cannabinoid 1 receptor antagonists as antiobesity agents. Expert Opin Ther Pat. 2015 Oct;25(10):1093-116. DMY5CFW RU https://pubmed.ncbi.nlm.nih.gov/26161824 DMP3JF4 DI DMP3JF4 DMP3JF4 DN Diphenyl purine derivative 4 DMP3JF4 MI TT6OEDT DMP3JF4 MN Cannabinoid receptor 1 (CB1) DMP3JF4 MT DTT DMP3JF4 MA Antagonist DMP3JF4 RN A comprehensive patents review on cannabinoid 1 receptor antagonists as antiobesity agents. Expert Opin Ther Pat. 2015 Oct;25(10):1093-116. DMP3JF4 RU https://pubmed.ncbi.nlm.nih.gov/26161824 DMC2T4H DI DMC2T4H DMC2T4H DN Diphenyl purine derivative 5 DMC2T4H MI TT6OEDT DMC2T4H MN Cannabinoid receptor 1 (CB1) DMC2T4H MT DTT DMC2T4H MA Antagonist DMC2T4H RN A comprehensive patents review on cannabinoid 1 receptor antagonists as antiobesity agents. Expert Opin Ther Pat. 2015 Oct;25(10):1093-116. DMC2T4H RU https://pubmed.ncbi.nlm.nih.gov/26161824 DM3OCXI DI DM3OCXI DM3OCXI DN Di-substituted piperidine derivative 1 DM3OCXI MI TTEB0GD DM3OCXI MN Cholinesterase (BCHE) DM3OCXI MT DTT DM3OCXI MA Inhibitor DM3OCXI RN A patent review of butyrylcholinesterase inhibitors and reactivators 2010-2017.Expert Opin Ther Pat. 2018 Jun;28(6):455-465. DM3OCXI RU https://www.ncbi.nlm.nih.gov/pubmed/29757691 DM23XQL DI DM23XQL DM23XQL DN Di-substituted piperidine derivative 2 DM23XQL MI TT1RS9F DM23XQL MN Acetylcholinesterase (AChE) DM23XQL MT DTT DM23XQL MA Inhibitor DM23XQL RN A patent review of butyrylcholinesterase inhibitors and reactivators 2010-2017.Expert Opin Ther Pat. 2018 Jun;28(6):455-465. DM23XQL RU https://www.ncbi.nlm.nih.gov/pubmed/29757691 DM23XQL DI DM23XQL DM23XQL DN Di-substituted piperidine derivative 2 DM23XQL MI TTEB0GD DM23XQL MN Cholinesterase (BCHE) DM23XQL MT DTT DM23XQL MA Inhibitor DM23XQL RN A patent review of butyrylcholinesterase inhibitors and reactivators 2010-2017.Expert Opin Ther Pat. 2018 Jun;28(6):455-465. DM23XQL RU https://www.ncbi.nlm.nih.gov/pubmed/29757691 DM2IBX9 DI DM2IBX9 DM2IBX9 DN Di-substituted piperidine derivative 3 DM2IBX9 MI TTEB0GD DM2IBX9 MN Cholinesterase (BCHE) DM2IBX9 MT DTT DM2IBX9 MA Inhibitor DM2IBX9 RN A patent review of butyrylcholinesterase inhibitors and reactivators 2010-2017.Expert Opin Ther Pat. 2018 Jun;28(6):455-465. DM2IBX9 RU https://www.ncbi.nlm.nih.gov/pubmed/29757691 DMTYL68 DI DMTYL68 DMTYL68 DN Disulfide compound 1 DMTYL68 MI TTR7UJ3 DMTYL68 MN Cytoplasmic thioredoxin reductase (TXNRD1) DMTYL68 MT DTT DMTYL68 MA Inhibitor DMTYL68 RN Thioredoxin reductase inhibitors: a patent review.Expert Opin Ther Pat. 2017 May;27(5):547-556. DMTYL68 RU https://www.ncbi.nlm.nih.gov/pubmed/27977313 DM6ON31 DI DM6ON31 DM6ON31 DN Disulfide compound 2 DM6ON31 MI TTR7UJ3 DM6ON31 MN Cytoplasmic thioredoxin reductase (TXNRD1) DM6ON31 MT DTT DM6ON31 MA Inhibitor DM6ON31 RN Thioredoxin reductase inhibitors: a patent review.Expert Opin Ther Pat. 2017 May;27(5):547-556. DM6ON31 RU https://www.ncbi.nlm.nih.gov/pubmed/27977313 DMOEFD3 DI DMOEFD3 DMOEFD3 DN Disulfiram analog 1 DMOEFD3 MI TTZHPB8 DMOEFD3 MN Lysine-specific demethylase 4A (KDM4A) DMOEFD3 MT DTT DMOEFD3 MA Inhibitor DMOEFD3 RN KDM4 histone demethylase inhibitors for anti-cancer agents: a patent review.Expert Opin Ther Pat. 2015 Feb;25(2):135-44. DMOEFD3 RU https://www.ncbi.nlm.nih.gov/pubmed/25468267 DMOMGU5 DI DMOMGU5 DMOMGU5 DN Disulfiram analog 2 DMOMGU5 MI TTZHPB8 DMOMGU5 MN Lysine-specific demethylase 4A (KDM4A) DMOMGU5 MT DTT DMOMGU5 MA Inhibitor DMOMGU5 RN KDM4 histone demethylase inhibitors for anti-cancer agents: a patent review.Expert Opin Ther Pat. 2015 Feb;25(2):135-44. DMOMGU5 RU https://www.ncbi.nlm.nih.gov/pubmed/25468267 DMYQHER DI DMYQHER DMYQHER DN Diterpene triepoxide derivative 1 DMYQHER MI TTLPJWH DMYQHER MN Thioredoxin reductase (PRDX5) DMYQHER MT DTT DMYQHER RN Thioredoxin reductase inhibitors: a patent review.Expert Opin Ther Pat. 2017 May;27(5):547-556. DMYQHER RU https://www.ncbi.nlm.nih.gov/pubmed/27977313 DMAZOH4 DI DMAZOH4 DMAZOH4 DN Diterpenoid derivative 1 DMAZOH4 MI TT3Z6Y9 DMAZOH4 MN Cysteines of Keap1 (KEAP1 Cysteines) DMAZOH4 MT DTT DMAZOH4 MA Modulator DMAZOH4 RN Recent progress in the development of small molecule Nrf2 modulators: a patent review (2012-2016).Expert Opin Ther Pat. 2017 Jul;27(7):763-785. DMAZOH4 RU https://www.ncbi.nlm.nih.gov/pubmed/28454500 DMAZOH4 DI DMAZOH4 DMAZOH4 DN Diterpenoid derivative 1 DMAZOH4 MI TTA6ZN2 DMAZOH4 MN Nuclear factor erythroid 2-related factor 2 (Nrf2) DMAZOH4 MT DTT DMAZOH4 MA Activator DMAZOH4 RN Recent progress in the development of small molecule Nrf2 modulators: a patent review (2012-2016).Expert Opin Ther Pat. 2017 Jul;27(7):763-785. DMAZOH4 RU https://www.ncbi.nlm.nih.gov/pubmed/28454500 DMKT19M DI DMKT19M DMKT19M DN Diterpenoid derivative 2 DMKT19M MI TT3Z6Y9 DMKT19M MN Cysteines of Keap1 (KEAP1 Cysteines) DMKT19M MT DTT DMKT19M MA Modulator DMKT19M RN Recent progress in the development of small molecule Nrf2 modulators: a patent review (2012-2016).Expert Opin Ther Pat. 2017 Jul;27(7):763-785. DMKT19M RU https://www.ncbi.nlm.nih.gov/pubmed/28454500 DMKT19M DI DMKT19M DMKT19M DN Diterpenoid derivative 2 DMKT19M MI TTA6ZN2 DMKT19M MN Nuclear factor erythroid 2-related factor 2 (Nrf2) DMKT19M MT DTT DMKT19M MA Activator DMKT19M RN Recent progress in the development of small molecule Nrf2 modulators: a patent review (2012-2016).Expert Opin Ther Pat. 2017 Jul;27(7):763-785. DMKT19M RU https://www.ncbi.nlm.nih.gov/pubmed/28454500 DM6BU7N DI DM6BU7N DM6BU7N DN Doramapimod DM6BU7N MI TT42OGM DM6BU7N MN Hematopoietic cell kinase (HCK) DM6BU7N MT DTT DM6BU7N MA Inhibitor DM6BU7N RN Respiratory formulations and compounds for use therein. US8933228. DM6BU7N RU http://www.freepatentsonline.com/US8933228.html DM2HLGC DI DM2HLGC DM2HLGC DN DZ9 DM2HLGC MI TT1NFO3 DM2HLGC MN Bacterial Nicotinate-nucleotide adenylyltransferase (Bact nadD) DM2HLGC MT DTT DM2HLGC MA Inhibitor DM2HLGC RN Targeting NAD biosynthesis in bacterial pathogens. US8785499. DM2HLGC RU http://www.freepatentsonline.com/US8785499.html DM5UM8I DI DM5UM8I DM5UM8I DN EEA DM5UM8I MI TTXLEG7 DM5UM8I MN Matrix metalloproteinase-10 (MMP-10) DM5UM8I MT DTT DM5UM8I MA Inhibitor DM5UM8I RN Pseudodipeptides as MMP inhibitors. US8691753. DM5UM8I RU http://www.freepatentsonline.com/US8691753.html DMR9IE5 DI DMR9IE5 DMR9IE5 DN EEC DMR9IE5 MI TTXLEG7 DMR9IE5 MN Matrix metalloproteinase-10 (MMP-10) DMR9IE5 MT DTT DMR9IE5 MA Inhibitor DMR9IE5 RN Pseudodipeptides as MMP inhibitors. US8691753. DMR9IE5 RU http://www.freepatentsonline.com/US8691753.html DMQF1UM DI DMQF1UM DMQF1UM DN Egonol compound 1 DMQF1UM MI TT1RS9F DMQF1UM MN Acetylcholinesterase (AChE) DMQF1UM MT DTT DMQF1UM MA Inhibitor DMQF1UM RN Recent advances in acetylcholinesterase Inhibitors and Reactivators: an update on the patent literature (2012-2015).Expert Opin Ther Pat. 2017 Apr;27(4):455-476. DMQF1UM RU https://www.ncbi.nlm.nih.gov/pubmed/27967267 DMQF1UM DI DMQF1UM DMQF1UM DN Egonol compound 1 DMQF1UM MI TTEB0GD DMQF1UM MN Cholinesterase (BCHE) DMQF1UM MT DTT DMQF1UM MA Inhibitor DMQF1UM RN Recent advances in acetylcholinesterase Inhibitors and Reactivators: an update on the patent literature (2012-2015).Expert Opin Ther Pat. 2017 Apr;27(4):455-476. DMQF1UM RU https://www.ncbi.nlm.nih.gov/pubmed/27967267 DMNBAZH DI DMNBAZH DMNBAZH DN Enol carbamate derivative 1 DMNBAZH MI TTDP1UC DMNBAZH MN Fatty acid amide hydrolase (FAAH) DMNBAZH MT DTT DMNBAZH MA Inhibitor DMNBAZH RN Fatty acid amide hydrolase inhibitors: a patent review (2009-2014).Expert Opin Ther Pat. 2015;25(11):1247-66. DMNBAZH RU https://www.ncbi.nlm.nih.gov/pubmed/26413912 DMJSIN8 DI DMJSIN8 DMJSIN8 DN Enzoxazolinone sulfonamide derivative 1 DMJSIN8 MI TT4G2JS DMJSIN8 MN Voltage-gated sodium channel alpha Nav1.7 (SCN9A) DMJSIN8 MT DTT DMJSIN8 MA Blocker DMJSIN8 RN Sodium channel blockers: a patent review (2010 - 2014).Expert Opin Ther Pat. 2015 Mar;25(3):279-90. DMJSIN8 RU https://www.ncbi.nlm.nih.gov/pubmed/25539043 DMU8LPN DI DMU8LPN DMU8LPN DN Epoxysuccinate derivative 1 DMU8LPN MI TTG5QB7 DMU8LPN MN Calpain-2 (CAPN2) DMU8LPN MT DTT DMU8LPN MA Inhibitor DMU8LPN RN An updated patent review of calpain inhibitors (2012 - 2014).Expert Opin Ther Pat. 2015 Jan;25(1):17-31. DMU8LPN RU https://www.ncbi.nlm.nih.gov/pubmed/25399719 DMYF39U DI DMYF39U DMYF39U DN Epoxysuccinate derivative 10 DMYF39U MI TTG5QB7 DMYF39U MN Calpain-2 (CAPN2) DMYF39U MT DTT DMYF39U MA Inhibitor DMYF39U RN An updated patent review of calpain inhibitors (2012 - 2014).Expert Opin Ther Pat. 2015 Jan;25(1):17-31. DMYF39U RU https://www.ncbi.nlm.nih.gov/pubmed/25399719 DMEV9O3 DI DMEV9O3 DMEV9O3 DN Epoxysuccinate derivative 2 DMEV9O3 MI TTG5QB7 DMEV9O3 MN Calpain-2 (CAPN2) DMEV9O3 MT DTT DMEV9O3 MA Inhibitor DMEV9O3 RN An updated patent review of calpain inhibitors (2012 - 2014).Expert Opin Ther Pat. 2015 Jan;25(1):17-31. DMEV9O3 RU https://www.ncbi.nlm.nih.gov/pubmed/25399719 DMMETW5 DI DMMETW5 DMMETW5 DN Epoxysuccinate derivative 3 DMMETW5 MI TTG5QB7 DMMETW5 MN Calpain-2 (CAPN2) DMMETW5 MT DTT DMMETW5 MA Inhibitor DMMETW5 RN An updated patent review of calpain inhibitors (2012 - 2014).Expert Opin Ther Pat. 2015 Jan;25(1):17-31. DMMETW5 RU https://www.ncbi.nlm.nih.gov/pubmed/25399719 DMCF6M8 DI DMCF6M8 DMCF6M8 DN Epoxysuccinate derivative 4 DMCF6M8 MI TTG5QB7 DMCF6M8 MN Calpain-2 (CAPN2) DMCF6M8 MT DTT DMCF6M8 MA Inhibitor DMCF6M8 RN An updated patent review of calpain inhibitors (2012 - 2014).Expert Opin Ther Pat. 2015 Jan;25(1):17-31. DMCF6M8 RU https://www.ncbi.nlm.nih.gov/pubmed/25399719 DM37MCN DI DM37MCN DM37MCN DN Epoxysuccinate derivative 5 DM37MCN MI TTG5QB7 DM37MCN MN Calpain-2 (CAPN2) DM37MCN MT DTT DM37MCN MA Inhibitor DM37MCN RN An updated patent review of calpain inhibitors (2012 - 2014).Expert Opin Ther Pat. 2015 Jan;25(1):17-31. DM37MCN RU https://www.ncbi.nlm.nih.gov/pubmed/25399719 DMQM6ZS DI DMQM6ZS DMQM6ZS DN Epoxysuccinate derivative 6 DMQM6ZS MI TTG5QB7 DMQM6ZS MN Calpain-2 (CAPN2) DMQM6ZS MT DTT DMQM6ZS MA Inhibitor DMQM6ZS RN An updated patent review of calpain inhibitors (2012 - 2014).Expert Opin Ther Pat. 2015 Jan;25(1):17-31. DMQM6ZS RU https://www.ncbi.nlm.nih.gov/pubmed/25399719 DMTSPVF DI DMTSPVF DMTSPVF DN Epoxysuccinate derivative 7 DMTSPVF MI TTG5QB7 DMTSPVF MN Calpain-2 (CAPN2) DMTSPVF MT DTT DMTSPVF MA Inhibitor DMTSPVF RN An updated patent review of calpain inhibitors (2012 - 2014).Expert Opin Ther Pat. 2015 Jan;25(1):17-31. DMTSPVF RU https://www.ncbi.nlm.nih.gov/pubmed/25399719 DMQTVPC DI DMQTVPC DMQTVPC DN Epoxysuccinate derivative 8 DMQTVPC MI TTG5QB7 DMQTVPC MN Calpain-2 (CAPN2) DMQTVPC MT DTT DMQTVPC MA Inhibitor DMQTVPC RN An updated patent review of calpain inhibitors (2012 - 2014).Expert Opin Ther Pat. 2015 Jan;25(1):17-31. DMQTVPC RU https://www.ncbi.nlm.nih.gov/pubmed/25399719 DM49FU0 DI DM49FU0 DM49FU0 DN Epoxysuccinate derivative 9 DM49FU0 MI TTG5QB7 DM49FU0 MN Calpain-2 (CAPN2) DM49FU0 MT DTT DM49FU0 MA Inhibitor DM49FU0 RN An updated patent review of calpain inhibitors (2012 - 2014).Expert Opin Ther Pat. 2015 Jan;25(1):17-31. DM49FU0 RU https://www.ncbi.nlm.nih.gov/pubmed/25399719 DM7XYRA DI DM7XYRA DM7XYRA DN Eptastatin derivative 1 DM7XYRA MI TTPADOQ DM7XYRA MN HMG-CoA reductase (HMGCR) DM7XYRA MT DTT DM7XYRA MA Inhibitor DM7XYRA RN HMG-CoA Reductase inhibitors: an updated review of patents of novel compounds and formulations (2011-2015).Expert Opin Ther Pat. 2016 Nov;26(11):1257-1272. DM7XYRA RU https://www.ncbi.nlm.nih.gov/pubmed/27537201 DMLOBAQ DI DMLOBAQ DMLOBAQ DN Ethinyl-pyrazole derivative 1 DMLOBAQ MI TTXJ47W DMLOBAQ MN Metabotropic glutamate receptor 2 (mGluR2) DMLOBAQ MT DTT DMLOBAQ MA Antagonist DMLOBAQ RN Novel metabotropic glutamate receptor 2/3 antagonists and their therapeutic applications: a patent review (2005 - present).Expert Opin Ther Pat. 2015 Jan;25(1):69-90. DMLOBAQ RU https://www.ncbi.nlm.nih.gov/pubmed/25435285 DMA3PE7 DI DMA3PE7 DMA3PE7 DN Ethinyl-pyrazole derivative 2 DMA3PE7 MI TTXJ47W DMA3PE7 MN Metabotropic glutamate receptor 2 (mGluR2) DMA3PE7 MT DTT DMA3PE7 MA Antagonist DMA3PE7 RN Novel metabotropic glutamate receptor 2/3 antagonists and their therapeutic applications: a patent review (2005 - present).Expert Opin Ther Pat. 2015 Jan;25(1):69-90. DMA3PE7 RU https://www.ncbi.nlm.nih.gov/pubmed/25435285 DM87DOX DI DM87DOX DM87DOX DN Ethinyl-pyrazole derivative 3 DM87DOX MI TTXJ47W DM87DOX MN Metabotropic glutamate receptor 2 (mGluR2) DM87DOX MT DTT DM87DOX MA Antagonist DM87DOX RN Novel metabotropic glutamate receptor 2/3 antagonists and their therapeutic applications: a patent review (2005 - present).Expert Opin Ther Pat. 2015 Jan;25(1):69-90. DM87DOX RU https://www.ncbi.nlm.nih.gov/pubmed/25435285 DMTBG39 DI DMTBG39 DMTBG39 DN Ethylaminopyrimidine derivative 1 DMTBG39 MI TTDP1UC DMTBG39 MN Fatty acid amide hydrolase (FAAH) DMTBG39 MT DTT DMTBG39 MA Inhibitor DMTBG39 RN Fatty acid amide hydrolase inhibitors: a patent review (2009-2014).Expert Opin Ther Pat. 2015;25(11):1247-66. DMTBG39 RU https://www.ncbi.nlm.nih.gov/pubmed/26413912 DMTBG39 DI DMTBG39 DMTBG39 DN Ethylaminopyrimidine derivative 1 DMTBG39 MI TTGX13H DMTBG39 MN Fatty-acid amide hydrolase 1 (FAAH1) DMTBG39 MT DTT DMTBG39 MA Inhibitor DMTBG39 RN Fatty acid amide hydrolase inhibitors: a patent review (2009-2014).Expert Opin Ther Pat. 2015;25(11):1247-66. DMTBG39 RU https://www.ncbi.nlm.nih.gov/pubmed/26413912 DM9WMJ1 DI DM9WMJ1 DM9WMJ1 DN Ethylvanillin DM9WMJ1 MI TTGP7BY DM9WMJ1 MN Monoamine oxidase type B (MAO-B) DM9WMJ1 MT DTT DM9WMJ1 MA Inhibitor DM9WMJ1 RN Novel monoamine oxidase inhibitors: a patent review (2012 - 2014).Expert Opin Ther Pat. 2015 Jan;25(1):91-110. DM9WMJ1 RU https://www.ncbi.nlm.nih.gov/pubmed/25399762 DMWXKRZ DI DMWXKRZ DMWXKRZ DN Ethynyl compound 1 DMWXKRZ MI TTHS256 DMWXKRZ MN Metabotropic glutamate receptor 5 (mGluR5) DMWXKRZ MT DTT DMWXKRZ MA Modulator DMWXKRZ RN mGlu5 negative allosteric modulators: a patent review (2013 - 2016).Expert Opin Ther Pat. 2017 Jun;27(6):691-706. DMWXKRZ RU https://www.ncbi.nlm.nih.gov/pubmed/28067079 DMJDG37 DI DMJDG37 DMJDG37 DN Ethynyl compound 2 DMJDG37 MI TTHS256 DMJDG37 MN Metabotropic glutamate receptor 5 (mGluR5) DMJDG37 MT DTT DMJDG37 MA Modulator DMJDG37 RN mGlu5 negative allosteric modulators: a patent review (2013 - 2016).Expert Opin Ther Pat. 2017 Jun;27(6):691-706. DMJDG37 RU https://www.ncbi.nlm.nih.gov/pubmed/28067079 DMD9PZQ DI DMD9PZQ DMD9PZQ DN Ethynyl compound 3 DMD9PZQ MI TTHS256 DMD9PZQ MN Metabotropic glutamate receptor 5 (mGluR5) DMD9PZQ MT DTT DMD9PZQ MA Modulator DMD9PZQ RN mGlu5 negative allosteric modulators: a patent review (2013 - 2016).Expert Opin Ther Pat. 2017 Jun;27(6):691-706. DMD9PZQ RU https://www.ncbi.nlm.nih.gov/pubmed/28067079 DMLDMO8 DI DMLDMO8 DMLDMO8 DN Ethynyl compound 4 DMLDMO8 MI TTHS256 DMLDMO8 MN Metabotropic glutamate receptor 5 (mGluR5) DMLDMO8 MT DTT DMLDMO8 MA Modulator DMLDMO8 RN mGlu5 negative allosteric modulators: a patent review (2013 - 2016).Expert Opin Ther Pat. 2017 Jun;27(6):691-706. DMLDMO8 RU https://www.ncbi.nlm.nih.gov/pubmed/28067079 DM53ZPE DI DM53ZPE DM53ZPE DN Ethynyl compound 5 DM53ZPE MI TTHS256 DM53ZPE MN Metabotropic glutamate receptor 5 (mGluR5) DM53ZPE MT DTT DM53ZPE MA Modulator DM53ZPE RN mGlu5 negative allosteric modulators: a patent review (2013 - 2016).Expert Opin Ther Pat. 2017 Jun;27(6):691-706. DM53ZPE RU https://www.ncbi.nlm.nih.gov/pubmed/28067079 DMDOEFC DI DMDOEFC DMDOEFC DN Ethynyl compound 6 DMDOEFC MI TTHS256 DMDOEFC MN Metabotropic glutamate receptor 5 (mGluR5) DMDOEFC MT DTT DMDOEFC MA Modulator DMDOEFC RN mGlu5 negative allosteric modulators: a patent review (2013 - 2016).Expert Opin Ther Pat. 2017 Jun;27(6):691-706. DMDOEFC RU https://www.ncbi.nlm.nih.gov/pubmed/28067079 DMPUG2M DI DMPUG2M DMPUG2M DN Ethynyl compound 7 DMPUG2M MI TTHS256 DMPUG2M MN Metabotropic glutamate receptor 5 (mGluR5) DMPUG2M MT DTT DMPUG2M MA Modulator DMPUG2M RN mGlu5 negative allosteric modulators: a patent review (2013 - 2016).Expert Opin Ther Pat. 2017 Jun;27(6):691-706. DMPUG2M RU https://www.ncbi.nlm.nih.gov/pubmed/28067079 DM7US1H DI DM7US1H DM7US1H DN Eugenol DM7US1H MI TTKPW01 DM7US1H MN Androgen receptor messenger RNA (AR mRNA) DM7US1H MT DTT DM7US1H MA Inhibitor DM7US1H RN Effect of essential oils, such as raspberry ketone and its derivatives, on antiandrogenic activity based on in vitro reporter gene assay. Bioorg Med Chem Lett. 2010 Apr 1;20(7):2111-4. DM7US1H RU https://pubmed.ncbi.nlm.nih.gov/20226658 DM7US1H DI DM7US1H DM7US1H DN Eugenol DM7US1H MI TTGP7BY DM7US1H MN Monoamine oxidase type B (MAO-B) DM7US1H MT DTT DM7US1H MA Inhibitor DM7US1H RN Novel monoamine oxidase inhibitors: a patent review (2012 - 2014).Expert Opin Ther Pat. 2015 Jan;25(1):91-110. DM7US1H RU https://www.ncbi.nlm.nih.gov/pubmed/25399762 DM7US1H DI DM7US1H DM7US1H DN Eugenol DM7US1H MI DEYGVN4 DM7US1H MN UDP-glucuronosyltransferase 1A1 (UGT1A1) DM7US1H MT DME DM7US1H MA Metabolism DM7US1H RN Differential and special properties of the major human UGT1-encoded gastrointestinal UDP-glucuronosyltransferases enhance potential to control chemical uptake. J Biol Chem. 2004 Jan 9;279(2):1429-41. DM7US1H RU https://www.ncbi.nlm.nih.gov/pubmed/?term=14557274 DM7US1H DI DM7US1H DM7US1H DN Eugenol DM7US1H MI DEZO4N3 DM7US1H MN UDP-glucuronosyltransferase 1A7 (UGT1A7) DM7US1H MT DME DM7US1H MA Metabolism DM7US1H RN Differential and special properties of the major human UGT1-encoded gastrointestinal UDP-glucuronosyltransferases enhance potential to control chemical uptake. J Biol Chem. 2004 Jan 9;279(2):1429-41. DM7US1H RU https://www.ncbi.nlm.nih.gov/pubmed/?term=14557274 DM7US1H DI DM7US1H DM7US1H DN Eugenol DM7US1H MI DE2GB8N DM7US1H MN UDP-glucuronosyltransferase 1A8 (UGT1A8) DM7US1H MT DME DM7US1H MA Metabolism DM7US1H RN Differential and special properties of the major human UGT1-encoded gastrointestinal UDP-glucuronosyltransferases enhance potential to control chemical uptake. J Biol Chem. 2004 Jan 9;279(2):1429-41. DM7US1H RU https://www.ncbi.nlm.nih.gov/pubmed/?term=14557274 DM7US1H DI DM7US1H DM7US1H DN Eugenol DM7US1H MI DE85D2P DM7US1H MN UDP-glucuronosyltransferase 1A9 (UGT1A9) DM7US1H MT DME DM7US1H MA Metabolism DM7US1H RN Differential and special properties of the major human UGT1-encoded gastrointestinal UDP-glucuronosyltransferases enhance potential to control chemical uptake. J Biol Chem. 2004 Jan 9;279(2):1429-41. DM7US1H RU https://www.ncbi.nlm.nih.gov/pubmed/?term=14557274 DMJC7NF DI DMJC7NF DMJC7NF DN Ferulic Acid DMJC7NF MI TTUNARX DMJC7NF MN Carbonic anhydrase (CA) DMJC7NF MT DTT DMJC7NF MA Inhibitor DMJC7NF RN Carbonic anhydrase inhibitors. Inhibition of mammalian isoforms I-XIV with a series of natural product polyphenols and phenolic acids. Bioorg Med Chem. 2010 Mar 15;18(6):2159-2164. DMJC7NF RU https://pubmed.ncbi.nlm.nih.gov/20185318 DMJC7NF DI DMJC7NF DMJC7NF DN Ferulic Acid DMJC7NF MI TTHQPL7 DMJC7NF MN Carbonic anhydrase I (CA-I) DMJC7NF MT DTT DMJC7NF MA Inhibitor DMJC7NF RN Carbonic anhydrase inhibitors. Inhibition of mammalian isoforms I-XIV with a series of natural product polyphenols and phenolic acids. Bioorg Med Chem. 2010 Mar 15;18(6):2159-2164. DMJC7NF RU https://pubmed.ncbi.nlm.nih.gov/20185318 DMJC7NF DI DMJC7NF DMJC7NF DN Ferulic Acid DMJC7NF MI TTANPDJ DMJC7NF MN Carbonic anhydrase II (CA-II) DMJC7NF MT DTT DMJC7NF MA Inhibitor DMJC7NF RN Carbonic anhydrase inhibitors. Inhibition of mammalian isoforms I-XIV with a series of natural product polyphenols and phenolic acids. Bioorg Med Chem. 2010 Mar 15;18(6):2159-2164. DMJC7NF RU https://pubmed.ncbi.nlm.nih.gov/20185318 DMJC7NF DI DMJC7NF DMJC7NF DN Ferulic Acid DMJC7NF MI TTZHA0O DMJC7NF MN Carbonic anhydrase IV (CA-IV) DMJC7NF MT DTT DMJC7NF MA Inhibitor DMJC7NF RN Carbonic anhydrase inhibitors. Inhibition of mammalian isoforms I-XIV with a series of natural product polyphenols and phenolic acids. Bioorg Med Chem. 2010 Mar 15;18(6):2159-2164. DMJC7NF RU https://pubmed.ncbi.nlm.nih.gov/20185318 DMJC7NF DI DMJC7NF DMJC7NF DN Ferulic Acid DMJC7NF MI TT2LVK8 DMJC7NF MN Carbonic anhydrase IX (CA-IX) DMJC7NF MT DTT DMJC7NF MA Inhibitor DMJC7NF RN Carbonic anhydrase inhibitors. Inhibition of mammalian isoforms I-XIV with a series of natural product polyphenols and phenolic acids. Bioorg Med Chem. 2010 Mar 15;18(6):2159-2164. DMJC7NF RU https://pubmed.ncbi.nlm.nih.gov/20185318 DMJC7NF DI DMJC7NF DMJC7NF DN Ferulic Acid DMJC7NF MI TTCFSPE DMJC7NF MN Carbonic anhydrase VI (CA-VI) DMJC7NF MT DTT DMJC7NF MA Inhibitor DMJC7NF RN Carbonic anhydrase inhibitors. Inhibition of mammalian isoforms I-XIV with a series of natural product polyphenols and phenolic acids. Bioorg Med Chem. 2010 Mar 15;18(6):2159-2164. DMJC7NF RU https://pubmed.ncbi.nlm.nih.gov/20185318 DMJC7NF DI DMJC7NF DMJC7NF DN Ferulic Acid DMJC7NF MI TTSYM0R DMJC7NF MN Carbonic anhydrase XII (CA-XII) DMJC7NF MT DTT DMJC7NF MA Inhibitor DMJC7NF RN Carbonic anhydrase inhibitors. Inhibition of mammalian isoforms I-XIV with a series of natural product polyphenols and phenolic acids. Bioorg Med Chem. 2010 Mar 15;18(6):2159-2164. DMJC7NF RU https://pubmed.ncbi.nlm.nih.gov/20185318 DMJC7NF DI DMJC7NF DMJC7NF DN Ferulic Acid DMJC7NF MI TTEYTKG DMJC7NF MN Carbonic anhydrase XIV (CA-XIV) DMJC7NF MT DTT DMJC7NF MA Inhibitor DMJC7NF RN Carbonic anhydrase inhibitors. Inhibition of mammalian isoforms I-XIV with a series of natural product polyphenols and phenolic acids. Bioorg Med Chem. 2010 Mar 15;18(6):2159-2164. DMJC7NF RU https://pubmed.ncbi.nlm.nih.gov/20185318 DMJC7NF DI DMJC7NF DMJC7NF DN Ferulic Acid DMJC7NF MI TTGP7BY DMJC7NF MN Monoamine oxidase type B (MAO-B) DMJC7NF MT DTT DMJC7NF MA Inhibitor DMJC7NF RN Novel monoamine oxidase inhibitors: a patent review (2012 - 2014).Expert Opin Ther Pat. 2015 Jan;25(1):91-110. DMJC7NF RU https://www.ncbi.nlm.nih.gov/pubmed/25399762 DMPFAST DI DMPFAST DMPFAST DN Five membered heterocyclic benzamide derivative 1 DMPFAST MI TTTDVOJ DMPFAST MN Tropomyosin-related kinase A (TrkA) DMPFAST MT DTT DMPFAST MA Inhibitor DMPFAST RN Tropomyosin receptor kinase inhibitors: an updated patent review for 2010-2016 - Part II.Expert Opin Ther Pat. 2017 Jul;27(7):831-849. DMPFAST RU https://www.ncbi.nlm.nih.gov/pubmed/28270021 DM4U63E DI DM4U63E DM4U63E DN Five membered heterocyclic benzamide derivative 2 DM4U63E MI TTTDVOJ DM4U63E MN Tropomyosin-related kinase A (TrkA) DM4U63E MT DTT DM4U63E MA Inhibitor DM4U63E RN Tropomyosin receptor kinase inhibitors: an updated patent review for 2010-2016 - Part II.Expert Opin Ther Pat. 2017 Jul;27(7):831-849. DM4U63E RU https://www.ncbi.nlm.nih.gov/pubmed/28270021 DMUS4Z0 DI DMUS4Z0 DMUS4Z0 DN Five membered heterocyclic benzamide derivative 3 DMUS4Z0 MI TTTDVOJ DMUS4Z0 MN Tropomyosin-related kinase A (TrkA) DMUS4Z0 MT DTT DMUS4Z0 MA Inhibitor DMUS4Z0 RN Tropomyosin receptor kinase inhibitors: an updated patent review for 2010-2016 - Part II.Expert Opin Ther Pat. 2017 Jul;27(7):831-849. DMUS4Z0 RU https://www.ncbi.nlm.nih.gov/pubmed/28270021 DM7SK5Q DI DM7SK5Q DM7SK5Q DN Five-and-six-membered heterocyclic compound 1 DM7SK5Q MI TT6DM01 DM7SK5Q MN Janus kinase 1 (JAK-1) DM7SK5Q MT DTT DM7SK5Q MA Inhibitor DM7SK5Q RN Inhibitors of JAK-family kinases: an update on the patent literature 2013-2015, part 2.Expert Opin Ther Pat. 2017 Feb;27(2):145-161. DM7SK5Q RU https://www.ncbi.nlm.nih.gov/pubmed/27774822 DM7SK5Q DI DM7SK5Q DM7SK5Q DN Five-and-six-membered heterocyclic compound 1 DM7SK5Q MI TTRMX3V DM7SK5Q MN Janus kinase 2 (JAK-2) DM7SK5Q MT DTT DM7SK5Q MA Inhibitor DM7SK5Q RN Inhibitors of JAK-family kinases: an update on the patent literature 2013-2015, part 2.Expert Opin Ther Pat. 2017 Feb;27(2):145-161. DM7SK5Q RU https://www.ncbi.nlm.nih.gov/pubmed/27774822 DM7SK5Q DI DM7SK5Q DM7SK5Q DN Five-and-six-membered heterocyclic compound 1 DM7SK5Q MI TTT7PJU DM7SK5Q MN Janus kinase 3 (JAK-3) DM7SK5Q MT DTT DM7SK5Q MA Inhibitor DM7SK5Q RN Inhibitors of JAK-family kinases: an update on the patent literature 2013-2015, part 2.Expert Opin Ther Pat. 2017 Feb;27(2):145-161. DM7SK5Q RU https://www.ncbi.nlm.nih.gov/pubmed/27774822 DMO8UKD DI DMO8UKD DMO8UKD DN Five-membered heteroaromatic compound 1 DMO8UKD MI TTZJYKH DMO8UKD MN Indoleamine 2,3-dioxygenase 1 (IDO1) DMO8UKD MT DTT DMO8UKD MA Inhibitor DMO8UKD RN A patent review of IDO1 inhibitors for cancer.Expert Opin Ther Pat. 2018 Apr;28(4):317-330. DMO8UKD RU https://www.ncbi.nlm.nih.gov/pubmed/29473428 DM1QH8Z DI DM1QH8Z DM1QH8Z DN Five-membered heteroaromatic compound 2 DM1QH8Z MI TTZJYKH DM1QH8Z MN Indoleamine 2,3-dioxygenase 1 (IDO1) DM1QH8Z MT DTT DM1QH8Z MA Inhibitor DM1QH8Z RN A patent review of IDO1 inhibitors for cancer.Expert Opin Ther Pat. 2018 Apr;28(4):317-330. DM1QH8Z RU https://www.ncbi.nlm.nih.gov/pubmed/29473428 DMS0P9E DI DMS0P9E DMS0P9E DN Five-membered heteroaromatic compound 3 DMS0P9E MI TTZJYKH DMS0P9E MN Indoleamine 2,3-dioxygenase 1 (IDO1) DMS0P9E MT DTT DMS0P9E MA Inhibitor DMS0P9E RN A patent review of IDO1 inhibitors for cancer.Expert Opin Ther Pat. 2018 Apr;28(4):317-330. DMS0P9E RU https://www.ncbi.nlm.nih.gov/pubmed/29473428 DMCQP0B DI DMCQP0B DMCQP0B DN Flavonoid derivative 1 DMCQP0B MI TTH8FZW DMCQP0B MN Signal transducer and activator of transcription 3 (STAT3) DMCQP0B MT DTT DMCQP0B MA Inhibitor DMCQP0B RN A STAT inhibitor patent review: progress since 2011.Expert Opin Ther Pat. 2015;25(12):1397-421. DMCQP0B RU https://www.ncbi.nlm.nih.gov/pubmed/26394986 DMWZARV DI DMWZARV DMWZARV DN Flavonoid derivative 2 DMWZARV MI TTH8FZW DMWZARV MN Signal transducer and activator of transcription 3 (STAT3) DMWZARV MT DTT DMWZARV MA Inhibitor DMWZARV RN A STAT inhibitor patent review: progress since 2011.Expert Opin Ther Pat. 2015;25(12):1397-421. DMWZARV RU https://www.ncbi.nlm.nih.gov/pubmed/26394986 DMT7ZEL DI DMT7ZEL DMT7ZEL DN Flavonoid derivative 3 DMT7ZEL MI TTH8FZW DMT7ZEL MN Signal transducer and activator of transcription 3 (STAT3) DMT7ZEL MT DTT DMT7ZEL MA Inhibitor DMT7ZEL RN A STAT inhibitor patent review: progress since 2011.Expert Opin Ther Pat. 2015;25(12):1397-421. DMT7ZEL RU https://www.ncbi.nlm.nih.gov/pubmed/26394986 DMMOSVD DI DMMOSVD DMMOSVD DN Flavonoid derivative 4 DMMOSVD MI TTH8FZW DMMOSVD MN Signal transducer and activator of transcription 3 (STAT3) DMMOSVD MT DTT DMMOSVD MA Inhibitor DMMOSVD RN A STAT inhibitor patent review: progress since 2011.Expert Opin Ther Pat. 2015;25(12):1397-421. DMMOSVD RU https://www.ncbi.nlm.nih.gov/pubmed/26394986 DMTWAJX DI DMTWAJX DMTWAJX DN Flavonoid derivative 5 DMTWAJX MI TTH8FZW DMTWAJX MN Signal transducer and activator of transcription 3 (STAT3) DMTWAJX MT DTT DMTWAJX MA Inhibitor DMTWAJX RN A STAT inhibitor patent review: progress since 2011.Expert Opin Ther Pat. 2015;25(12):1397-421. DMTWAJX RU https://www.ncbi.nlm.nih.gov/pubmed/26394986 DM0E38G DI DM0E38G DM0E38G DN Flavonoid derivative 6 DM0E38G MI TTV8CRH DM0E38G MN Lysine-specific demethylase 4C (KDM4C) DM0E38G MT DTT DM0E38G MA Inhibitor DM0E38G RN KDM4 histone demethylase inhibitors for anti-cancer agents: a patent review.Expert Opin Ther Pat. 2015 Feb;25(2):135-44. DM0E38G RU https://www.ncbi.nlm.nih.gov/pubmed/25468267 DM6A9UR DI DM6A9UR DM6A9UR DN Flavonoid derivative 7 DM6A9UR MI TTL4Q97 DM6A9UR MN Cyclin-dependent kinase 5 (CDK5) DM6A9UR MT DTT DM6A9UR MA Inhibitor DM6A9UR RN Cyclin-dependent kinase inhibitors for cancer therapy: a patent review (2009 - 2014).Expert Opin Ther Pat. 2015;25(9):953-70. DM6A9UR RU https://www.ncbi.nlm.nih.gov/pubmed/26161698 DM4O9T3 DI DM4O9T3 DM4O9T3 DN Flavonoid derivative 8 DM4O9T3 MI TTJ584C DM4O9T3 MN Peroxisome proliferator-activated receptor alpha (PPARA) DM4O9T3 MT DTT DM4O9T3 MA Agonist DM4O9T3 RN PPAR ligands and their therapeutic applications: a patent review (2008 - 2014).Expert Opin Ther Pat. 2015 Feb;25(2):175-91. DM4O9T3 RU https://www.ncbi.nlm.nih.gov/pubmed/25416646 DM4O9T3 DI DM4O9T3 DM4O9T3 DN Flavonoid derivative 8 DM4O9T3 MI TTZMAO3 DM4O9T3 MN Peroxisome proliferator-activated receptor gamma (PPAR-gamma) DM4O9T3 MT DTT DM4O9T3 MA Agonist DM4O9T3 RN PPAR ligands and their therapeutic applications: a patent review (2008 - 2014).Expert Opin Ther Pat. 2015 Feb;25(2):175-91. DM4O9T3 RU https://www.ncbi.nlm.nih.gov/pubmed/25416646 DMXL3A5 DI DMXL3A5 DMXL3A5 DN Flavopiridol analog 1 DMXL3A5 MI TT7HF4W DMXL3A5 MN Cyclin-dependent kinase 2 (CDK2) DMXL3A5 MT DTT DMXL3A5 MA Inhibitor DMXL3A5 RN Cyclin-dependent kinase inhibitors for cancer therapy: a patent review (2009 - 2014).Expert Opin Ther Pat. 2015;25(9):953-70. DMXL3A5 RU https://www.ncbi.nlm.nih.gov/pubmed/26161698 DMXL3A5 DI DMXL3A5 DMXL3A5 DN Flavopiridol analog 1 DMXL3A5 MI TT1LVF2 DMXL3A5 MN Cyclin-dependent kinase 9 (CDK9) DMXL3A5 MT DTT DMXL3A5 MA Inhibitor DMXL3A5 RN Cyclin-dependent kinase inhibitors for cancer therapy: a patent review (2009 - 2014).Expert Opin Ther Pat. 2015;25(9):953-70. DMXL3A5 RU https://www.ncbi.nlm.nih.gov/pubmed/26161698 DMGOSN2 DI DMGOSN2 DMGOSN2 DN Fluorinated compound 1 DMGOSN2 MI TT7HF4W DMGOSN2 MN Cyclin-dependent kinase 2 (CDK2) DMGOSN2 MT DTT DMGOSN2 MA Inhibitor DMGOSN2 RN Cyclin-dependent kinase inhibitors for cancer therapy: a patent review (2009 - 2014).Expert Opin Ther Pat. 2015;25(9):953-70. DMGOSN2 RU https://www.ncbi.nlm.nih.gov/pubmed/26161698 DMQOGHN DI DMQOGHN DMQOGHN DN Fluorinated donepezil derivative 1 DMQOGHN MI TT1RS9F DMQOGHN MN Acetylcholinesterase (AChE) DMQOGHN MT DTT DMQOGHN MA Inhibitor DMQOGHN RN Recent advances in acetylcholinesterase Inhibitors and Reactivators: an update on the patent literature (2012-2015).Expert Opin Ther Pat. 2017 Apr;27(4):455-476. DMQOGHN RU https://www.ncbi.nlm.nih.gov/pubmed/27967267 DMV1SCA DI DMV1SCA DMV1SCA DN Fluorinated donepezil derivative 2 DMV1SCA MI TT1RS9F DMV1SCA MN Acetylcholinesterase (AChE) DMV1SCA MT DTT DMV1SCA MA Inhibitor DMV1SCA RN Recent advances in acetylcholinesterase Inhibitors and Reactivators: an update on the patent literature (2012-2015).Expert Opin Ther Pat. 2017 Apr;27(4):455-476. DMV1SCA RU https://www.ncbi.nlm.nih.gov/pubmed/27967267 DMTS8O9 DI DMTS8O9 DMTS8O9 DN Fluorophenyl-substituted heterocyclic amide analog 1 DMTS8O9 MI TT473XN DMTS8O9 MN P2X purinoceptor 7 (P2RX7) DMTS8O9 MT DTT DMTS8O9 MA Antagonist DMTS8O9 RN P2X7 receptor antagonists: a patent review (2010-2015).Expert Opin Ther Pat. 2017 Mar;27(3):257-267. DMTS8O9 RU https://www.ncbi.nlm.nih.gov/pubmed/27724045 DM2QXVW DI DM2QXVW DM2QXVW DN Furopyridine derivative 1 DM2QXVW MI TT6OEDT DM2QXVW MN Cannabinoid receptor 1 (CB1) DM2QXVW MT DTT DM2QXVW MA Antagonist DM2QXVW RN A comprehensive patents review on cannabinoid 1 receptor antagonists as antiobesity agents. Expert Opin Ther Pat. 2015 Oct;25(10):1093-116. DM2QXVW RU https://pubmed.ncbi.nlm.nih.gov/26161824 DMEU3J9 DI DMEU3J9 DMEU3J9 DN Furopyridine derivative 2 DMEU3J9 MI TT6OEDT DMEU3J9 MN Cannabinoid receptor 1 (CB1) DMEU3J9 MT DTT DMEU3J9 MA Antagonist DMEU3J9 RN A comprehensive patents review on cannabinoid 1 receptor antagonists as antiobesity agents. Expert Opin Ther Pat. 2015 Oct;25(10):1093-116. DMEU3J9 RU https://pubmed.ncbi.nlm.nih.gov/26161824 DM4EUFL DI DM4EUFL DM4EUFL DN Fused aromatic compound 1 DM4EUFL MI TTZMAO3 DM4EUFL MN Peroxisome proliferator-activated receptor gamma (PPAR-gamma) DM4EUFL MT DTT DM4EUFL MA Agonist DM4EUFL RN PPAR ligands and their therapeutic applications: a patent review (2008 - 2014).Expert Opin Ther Pat. 2015 Feb;25(2):175-91. DM4EUFL RU https://www.ncbi.nlm.nih.gov/pubmed/25416646 DMFAM8B DI DMFAM8B DMFAM8B DN Fused aryl carbocycle derivative 1 DMFAM8B MI TT9NXW4 DMFAM8B MN Sigma intracellular receptor 2 (TMEM97) DMFAM8B MT DTT DMFAM8B MA Ligand DMFAM8B RN The sigma-2 (-2) receptor: a review of recent patent applications: 2013-2018.Expert Opin Ther Pat. 2018 Sep;28(9):655-663. DMFAM8B RU https://www.ncbi.nlm.nih.gov/pubmed/30185082 DMAQBJP DI DMAQBJP DMAQBJP DN Fused aryl carbocycle derivative 2 DMAQBJP MI TT9NXW4 DMAQBJP MN Sigma intracellular receptor 2 (TMEM97) DMAQBJP MT DTT DMAQBJP MA Ligand DMAQBJP RN The sigma-2 (-2) receptor: a review of recent patent applications: 2013-2018.Expert Opin Ther Pat. 2018 Sep;28(9):655-663. DMAQBJP RU https://www.ncbi.nlm.nih.gov/pubmed/30185082 DM5I4CA DI DM5I4CA DM5I4CA DN Fused aryl carbocycle derivative 3 DM5I4CA MI TT9NXW4 DM5I4CA MN Sigma intracellular receptor 2 (TMEM97) DM5I4CA MT DTT DM5I4CA MA Ligand DM5I4CA RN The sigma-2 (-2) receptor: a review of recent patent applications: 2013-2018.Expert Opin Ther Pat. 2018 Sep;28(9):655-663. DM5I4CA RU https://www.ncbi.nlm.nih.gov/pubmed/30185082 DMOU8T3 DI DMOU8T3 DMOU8T3 DN Fused aryl carbocycle derivative 4 DMOU8T3 MI TT9NXW4 DMOU8T3 MN Sigma intracellular receptor 2 (TMEM97) DMOU8T3 MT DTT DMOU8T3 MA Ligand DMOU8T3 RN The sigma-2 (-2) receptor: a review of recent patent applications: 2013-2018.Expert Opin Ther Pat. 2018 Sep;28(9):655-663. DMOU8T3 RU https://www.ncbi.nlm.nih.gov/pubmed/30185082 DMPBMEU DI DMPBMEU DMPBMEU DN Fused aryl carbocycle derivative 8 DMPBMEU MI TT9NXW4 DMPBMEU MN Sigma intracellular receptor 2 (TMEM97) DMPBMEU MT DTT DMPBMEU MA Ligand DMPBMEU RN The sigma-2 (-2) receptor: a review of recent patent applications: 2013-2018.Expert Opin Ther Pat. 2018 Sep;28(9):655-663. DMPBMEU RU https://www.ncbi.nlm.nih.gov/pubmed/30185082 DMQ2X6O DI DMQ2X6O DMQ2X6O DN Fused aryl carbocycle derivative 9 DMQ2X6O MI TT9NXW4 DMQ2X6O MN Sigma intracellular receptor 2 (TMEM97) DMQ2X6O MT DTT DMQ2X6O MA Ligand DMQ2X6O RN The sigma-2 (-2) receptor: a review of recent patent applications: 2013-2018.Expert Opin Ther Pat. 2018 Sep;28(9):655-663. DMQ2X6O RU https://www.ncbi.nlm.nih.gov/pubmed/30185082 DMKLO2H DI DMKLO2H DMKLO2H DN Fused benzoheterocycle amide derivative 1 DMKLO2H MI TTKFVXR DMKLO2H MN Renal carcinoma antigen NY-REN-64 (IRAK-4) DMKLO2H MT DTT DMKLO2H MA Inhibitor DMKLO2H RN Inhibitors of interleukin-1 receptor-associated kinase 4 (IRAK4): a patent review (2012-2015).Expert Opin Ther Pat. 2016 Aug;26(8):917-32. DMKLO2H RU https://www.ncbi.nlm.nih.gov/pubmed/27310003 DM9NMHS DI DM9NMHS DM9NMHS DN Fused benzoheterocycle amide derivative 2 DM9NMHS MI TTKFVXR DM9NMHS MN Renal carcinoma antigen NY-REN-64 (IRAK-4) DM9NMHS MT DTT DM9NMHS MA Inhibitor DM9NMHS RN Inhibitors of interleukin-1 receptor-associated kinase 4 (IRAK4): a patent review (2012-2015).Expert Opin Ther Pat. 2016 Aug;26(8):917-32. DM9NMHS RU https://www.ncbi.nlm.nih.gov/pubmed/27310003 DMVU9RG DI DMVU9RG DMVU9RG DN Fused heterocyclic compound 1 DMVU9RG MI TT7RJY8 DMVU9RG MN Xanthine dehydrogenase/oxidase (XDH) DMVU9RG MT DTT DMVU9RG MA Inhibitor DMVU9RG RN An updated patent review: xanthine oxidase inhibitors for the treatment of hyperuricemia and gout (2011-2015).Expert Opin Ther Pat. 2017 Mar;27(3):311-345. DMVU9RG RU https://www.ncbi.nlm.nih.gov/pubmed/27841045 DMALDZ6 DI DMALDZ6 DMALDZ6 DN Fused heterocyclic compound 10 DMALDZ6 MI TT7RJY8 DMALDZ6 MN Xanthine dehydrogenase/oxidase (XDH) DMALDZ6 MT DTT DMALDZ6 MA Inhibitor DMALDZ6 RN An updated patent review: xanthine oxidase inhibitors for the treatment of hyperuricemia and gout (2011-2015).Expert Opin Ther Pat. 2017 Mar;27(3):311-345. DMALDZ6 RU https://www.ncbi.nlm.nih.gov/pubmed/27841045 DMJC4UZ DI DMJC4UZ DMJC4UZ DN Fused heterocyclic compound 11 DMJC4UZ MI TT7RJY8 DMJC4UZ MN Xanthine dehydrogenase/oxidase (XDH) DMJC4UZ MT DTT DMJC4UZ MA Inhibitor DMJC4UZ RN An updated patent review: xanthine oxidase inhibitors for the treatment of hyperuricemia and gout (2011-2015).Expert Opin Ther Pat. 2017 Mar;27(3):311-345. DMJC4UZ RU https://www.ncbi.nlm.nih.gov/pubmed/27841045 DMSYD6Z DI DMSYD6Z DMSYD6Z DN Fused heterocyclic compound 12 DMSYD6Z MI TTA592U DMSYD6Z MN Urate anion exchanger 1 (URAT1) DMSYD6Z MT DTT DMSYD6Z MA Inhibitor DMSYD6Z RN Urate transporter URAT1 inhibitors: a patent review (2012 - 2015).Expert Opin Ther Pat. 2016 Jul 30:1-10. DMSYD6Z RU https://www.ncbi.nlm.nih.gov/pubmed/27414413 DM361J8 DI DM361J8 DM361J8 DN Fused heterocyclic compound 2 DM361J8 MI TT7RJY8 DM361J8 MN Xanthine dehydrogenase/oxidase (XDH) DM361J8 MT DTT DM361J8 MA Inhibitor DM361J8 RN An updated patent review: xanthine oxidase inhibitors for the treatment of hyperuricemia and gout (2011-2015).Expert Opin Ther Pat. 2017 Mar;27(3):311-345. DM361J8 RU https://www.ncbi.nlm.nih.gov/pubmed/27841045 DM2QVHY DI DM2QVHY DM2QVHY DN Fused heterocyclic compound 3 DM2QVHY MI TT7RJY8 DM2QVHY MN Xanthine dehydrogenase/oxidase (XDH) DM2QVHY MT DTT DM2QVHY MA Inhibitor DM2QVHY RN An updated patent review: xanthine oxidase inhibitors for the treatment of hyperuricemia and gout (2011-2015).Expert Opin Ther Pat. 2017 Mar;27(3):311-345. DM2QVHY RU https://www.ncbi.nlm.nih.gov/pubmed/27841045 DMHTS5G DI DMHTS5G DMHTS5G DN Fused heterocyclic compound 4 DMHTS5G MI TT7RJY8 DMHTS5G MN Xanthine dehydrogenase/oxidase (XDH) DMHTS5G MT DTT DMHTS5G MA Inhibitor DMHTS5G RN An updated patent review: xanthine oxidase inhibitors for the treatment of hyperuricemia and gout (2011-2015).Expert Opin Ther Pat. 2017 Mar;27(3):311-345. DMHTS5G RU https://www.ncbi.nlm.nih.gov/pubmed/27841045 DM10CGB DI DM10CGB DM10CGB DN Fused heterocyclic compound 5 DM10CGB MI TT7RJY8 DM10CGB MN Xanthine dehydrogenase/oxidase (XDH) DM10CGB MT DTT DM10CGB MA Inhibitor DM10CGB RN An updated patent review: xanthine oxidase inhibitors for the treatment of hyperuricemia and gout (2011-2015).Expert Opin Ther Pat. 2017 Mar;27(3):311-345. DM10CGB RU https://www.ncbi.nlm.nih.gov/pubmed/27841045 DM9DC3U DI DM9DC3U DM9DC3U DN Fused heterocyclic compound 6 DM9DC3U MI TT7RJY8 DM9DC3U MN Xanthine dehydrogenase/oxidase (XDH) DM9DC3U MT DTT DM9DC3U MA Inhibitor DM9DC3U RN An updated patent review: xanthine oxidase inhibitors for the treatment of hyperuricemia and gout (2011-2015).Expert Opin Ther Pat. 2017 Mar;27(3):311-345. DM9DC3U RU https://www.ncbi.nlm.nih.gov/pubmed/27841045 DMGNWJD DI DMGNWJD DMGNWJD DN Fused heterocyclic compound 7 DMGNWJD MI TT7RJY8 DMGNWJD MN Xanthine dehydrogenase/oxidase (XDH) DMGNWJD MT DTT DMGNWJD MA Inhibitor DMGNWJD RN An updated patent review: xanthine oxidase inhibitors for the treatment of hyperuricemia and gout (2011-2015).Expert Opin Ther Pat. 2017 Mar;27(3):311-345. DMGNWJD RU https://www.ncbi.nlm.nih.gov/pubmed/27841045 DMO8JE7 DI DMO8JE7 DMO8JE7 DN Fused heterocyclic compound 8 DMO8JE7 MI TT7RJY8 DMO8JE7 MN Xanthine dehydrogenase/oxidase (XDH) DMO8JE7 MT DTT DMO8JE7 MA Inhibitor DMO8JE7 RN An updated patent review: xanthine oxidase inhibitors for the treatment of hyperuricemia and gout (2011-2015).Expert Opin Ther Pat. 2017 Mar;27(3):311-345. DMO8JE7 RU https://www.ncbi.nlm.nih.gov/pubmed/27841045 DM25IMA DI DM25IMA DM25IMA DN Fused heterocyclic compound 9 DM25IMA MI TT7RJY8 DM25IMA MN Xanthine dehydrogenase/oxidase (XDH) DM25IMA MT DTT DM25IMA MA Inhibitor DM25IMA RN An updated patent review: xanthine oxidase inhibitors for the treatment of hyperuricemia and gout (2011-2015).Expert Opin Ther Pat. 2017 Mar;27(3):311-345. DM25IMA RU https://www.ncbi.nlm.nih.gov/pubmed/27841045 DMPHL3J DI DMPHL3J DMPHL3J DN Fused ring compound 1 DMPHL3J MI TTZMAO3 DMPHL3J MN Peroxisome proliferator-activated receptor gamma (PPAR-gamma) DMPHL3J MT DTT DMPHL3J MA Agonist DMPHL3J RN PPAR ligands and their therapeutic applications: a patent review (2008 - 2014).Expert Opin Ther Pat. 2015 Feb;25(2):175-91. DMPHL3J RU https://www.ncbi.nlm.nih.gov/pubmed/25416646 DMV7IX4 DI DMV7IX4 DMV7IX4 DN Fused thiophene derivative 1 DMV7IX4 MI TTK0FEA DMV7IX4 MN Leucine-rich repeat kinase 2 (LRRK2) DMV7IX4 MT DTT DMV7IX4 MA Inhibitor DMV7IX4 RN Leucine-rich repeat kinase 2 inhibitors: a patent review (2014-2016).Expert Opin Ther Pat. 2017 Jun;27(6):667-676. DMV7IX4 RU https://www.ncbi.nlm.nih.gov/pubmed/28117607 DMV7IX4 DI DMV7IX4 DMV7IX4 DN Fused thiophene derivative 1 DMV7IX4 MI TTC7A6G DMV7IX4 MN Leucine-rich repeat kinase 2 S935 phosphorylation (LRRK2 pS935) DMV7IX4 MT DTT DMV7IX4 MA Inhibitor DMV7IX4 RN Leucine-rich repeat kinase 2 inhibitors: a patent review (2014-2016).Expert Opin Ther Pat. 2017 Jun;27(6):667-676. DMV7IX4 RU https://www.ncbi.nlm.nih.gov/pubmed/28117607 DM4Z72S DI DM4Z72S DM4Z72S DN Fused triazoloamino-phenyl analog 1 DM4Z72S MI TT473XN DM4Z72S MN P2X purinoceptor 7 (P2RX7) DM4Z72S MT DTT DM4Z72S MA Antagonist DM4Z72S RN P2X7 receptor antagonists: a patent review (2010-2015).Expert Opin Ther Pat. 2017 Mar;27(3):257-267. DM4Z72S RU https://www.ncbi.nlm.nih.gov/pubmed/27724045 DM5BVCS DI DM5BVCS DM5BVCS DN Galantamine analog 1 DM5BVCS MI TT1RS9F DM5BVCS MN Acetylcholinesterase (AChE) DM5BVCS MT DTT DM5BVCS MA Inhibitor DM5BVCS RN Recent advances in acetylcholinesterase Inhibitors and Reactivators: an update on the patent literature (2012-2015).Expert Opin Ther Pat. 2017 Apr;27(4):455-476. DM5BVCS RU https://www.ncbi.nlm.nih.gov/pubmed/27967267 DMK6RFS DI DMK6RFS DMK6RFS DN Geminally-substituted cyanoethylpypazolo pyridone derivative 1 DMK6RFS MI TT6DM01 DMK6RFS MN Janus kinase 1 (JAK-1) DMK6RFS MT DTT DMK6RFS MA Inhibitor DMK6RFS RN Inhibitors of JAK-family kinases: an update on the patent literature 2013-2015, part 2.Expert Opin Ther Pat. 2017 Feb;27(2):145-161. DMK6RFS RU https://www.ncbi.nlm.nih.gov/pubmed/27774822 DMK6RFS DI DMK6RFS DMK6RFS DN Geminally-substituted cyanoethylpypazolo pyridone derivative 1 DMK6RFS MI TTRMX3V DMK6RFS MN Janus kinase 2 (JAK-2) DMK6RFS MT DTT DMK6RFS MA Inhibitor DMK6RFS RN Inhibitors of JAK-family kinases: an update on the patent literature 2013-2015, part 2.Expert Opin Ther Pat. 2017 Feb;27(2):145-161. DMK6RFS RU https://www.ncbi.nlm.nih.gov/pubmed/27774822 DMB2INX DI DMB2INX DMB2INX DN Geminally-substituted cyanoethylpypazolo pyridone derivative 2 DMB2INX MI TT6DM01 DMB2INX MN Janus kinase 1 (JAK-1) DMB2INX MT DTT DMB2INX MA Inhibitor DMB2INX RN Inhibitors of JAK-family kinases: an update on the patent literature 2013-2015, part 2.Expert Opin Ther Pat. 2017 Feb;27(2):145-161. DMB2INX RU https://www.ncbi.nlm.nih.gov/pubmed/27774822 DMB2INX DI DMB2INX DMB2INX DN Geminally-substituted cyanoethylpypazolo pyridone derivative 2 DMB2INX MI TTRMX3V DMB2INX MN Janus kinase 2 (JAK-2) DMB2INX MT DTT DMB2INX MA Inhibitor DMB2INX RN Inhibitors of JAK-family kinases: an update on the patent literature 2013-2015, part 2.Expert Opin Ther Pat. 2017 Feb;27(2):145-161. DMB2INX RU https://www.ncbi.nlm.nih.gov/pubmed/27774822 DMT1EH9 DI DMT1EH9 DMT1EH9 DN Gold-complexed thiosaccharide derivative 1 DMT1EH9 MI TTH8FZW DMT1EH9 MN Signal transducer and activator of transcription 3 (STAT3) DMT1EH9 MT DTT DMT1EH9 MA Inhibitor DMT1EH9 RN A STAT inhibitor patent review: progress since 2011.Expert Opin Ther Pat. 2015;25(12):1397-421. DMT1EH9 RU https://www.ncbi.nlm.nih.gov/pubmed/26394986 DM9U4OZ DI DM9U4OZ DM9U4OZ DN Gold-complexed thiosaccharide derivative 2 DM9U4OZ MI TTH8FZW DM9U4OZ MN Signal transducer and activator of transcription 3 (STAT3) DM9U4OZ MT DTT DM9U4OZ MA Inhibitor DM9U4OZ RN A STAT inhibitor patent review: progress since 2011.Expert Opin Ther Pat. 2015;25(12):1397-421. DM9U4OZ RU https://www.ncbi.nlm.nih.gov/pubmed/26394986 DMMOGL8 DI DMMOGL8 DMMOGL8 DN Gold-complexed thiosaccharide derivative 3 DMMOGL8 MI TTH8FZW DMMOGL8 MN Signal transducer and activator of transcription 3 (STAT3) DMMOGL8 MT DTT DMMOGL8 MA Inhibitor DMMOGL8 RN A STAT inhibitor patent review: progress since 2011.Expert Opin Ther Pat. 2015;25(12):1397-421. DMMOGL8 RU https://www.ncbi.nlm.nih.gov/pubmed/26394986 DMVAKUI DI DMVAKUI DMVAKUI DN Golden phosphorous acetyletic compound 1 DMVAKUI MI TTR7UJ3 DMVAKUI MN Cytoplasmic thioredoxin reductase (TXNRD1) DMVAKUI MT DTT DMVAKUI MA Inhibitor DMVAKUI RN Thioredoxin reductase inhibitors: a patent review.Expert Opin Ther Pat. 2017 May;27(5):547-556. DMVAKUI RU https://www.ncbi.nlm.nih.gov/pubmed/27977313 DMVAKUI DI DMVAKUI DMVAKUI DN Golden phosphorous acetyletic compound 1 DMVAKUI MI TTEP6RV DMVAKUI MN Glutathione reductase (GR) DMVAKUI MT DTT DMVAKUI MA Inhibitor DMVAKUI RN Thioredoxin reductase inhibitors: a patent review.Expert Opin Ther Pat. 2017 May;27(5):547-556. DMVAKUI RU https://www.ncbi.nlm.nih.gov/pubmed/27977313 DMYJ15A DI DMYJ15A DMYJ15A DN Golden phosphorous acetyletic compound 2 DMYJ15A MI TTR7UJ3 DMYJ15A MN Cytoplasmic thioredoxin reductase (TXNRD1) DMYJ15A MT DTT DMYJ15A MA Inhibitor DMYJ15A RN Thioredoxin reductase inhibitors: a patent review.Expert Opin Ther Pat. 2017 May;27(5):547-556. DMYJ15A RU https://www.ncbi.nlm.nih.gov/pubmed/27977313 DMYJ15A DI DMYJ15A DMYJ15A DN Golden phosphorous acetyletic compound 2 DMYJ15A MI TTEP6RV DMYJ15A MN Glutathione reductase (GR) DMYJ15A MT DTT DMYJ15A MA Inhibitor DMYJ15A RN Thioredoxin reductase inhibitors: a patent review.Expert Opin Ther Pat. 2017 May;27(5):547-556. DMYJ15A RU https://www.ncbi.nlm.nih.gov/pubmed/27977313 DMRUCK8 DI DMRUCK8 DMRUCK8 DN Golden phosphorous acetyletic compound 3 DMRUCK8 MI TTR7UJ3 DMRUCK8 MN Cytoplasmic thioredoxin reductase (TXNRD1) DMRUCK8 MT DTT DMRUCK8 MA Inhibitor DMRUCK8 RN Thioredoxin reductase inhibitors: a patent review.Expert Opin Ther Pat. 2017 May;27(5):547-556. DMRUCK8 RU https://www.ncbi.nlm.nih.gov/pubmed/27977313 DMFHC0O DI DMFHC0O DMFHC0O DN GypensapogeninA DMFHC0O MI TT3WG5C DMFHC0O MN Monoamine oxidase type A (MAO-A) DMFHC0O MT DTT DMFHC0O MA Inhibitor DMFHC0O RN Novel monoamine oxidase inhibitors: a patent review (2012 - 2014).Expert Opin Ther Pat. 2015 Jan;25(1):91-110. DMFHC0O RU https://www.ncbi.nlm.nih.gov/pubmed/25399762 DMX4ET5 DI DMX4ET5 DMX4ET5 DN GypensapogeninB DMX4ET5 MI TT3WG5C DMX4ET5 MN Monoamine oxidase type A (MAO-A) DMX4ET5 MT DTT DMX4ET5 MA Inhibitor DMX4ET5 RN Novel monoamine oxidase inhibitors: a patent review (2012 - 2014).Expert Opin Ther Pat. 2015 Jan;25(1):91-110. DMX4ET5 RU https://www.ncbi.nlm.nih.gov/pubmed/25399762 DMM78UR DI DMM78UR DMM78UR DN H3K7T DMM78UR MI TTSCO7R DMM78UR MN NAD-dependent deacetylase sirtuin (SIRT) DMM78UR MT DTT DMM78UR MA Inhibitor DMM78UR RN Sirtuin modulators: an updated patent review (2012 - 2014).Expert Opin Ther Pat. 2015 Jan;25(1):5-15. DMM78UR RU https://www.ncbi.nlm.nih.gov/pubmed/25435179 DMPA5WD DI DMPA5WD DMPA5WD DN Harmine DMPA5WD MI TTSBVFO DMPA5WD MN Dual-specificity tyrosine-phosphorylation regulated kinase 1A (DYRK1A) DMPA5WD MT DTT DMPA5WD MA Inhibitor DMPA5WD RN Dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A) inhibitors: a survey of recent patent literature.Expert Opin Ther Pat. 2017 Nov;27(11):1183-1199. DMPA5WD RU https://www.ncbi.nlm.nih.gov/pubmed/28766366 DMPA5WD DI DMPA5WD DMPA5WD DN Harmine DMPA5WD MI TT84OS6 DMPA5WD MN Dual-specificity tyrosine-phosphorylation regulated kinase 2 (DYRK2) DMPA5WD MT DTT DMPA5WD MA Inhibitor DMPA5WD RN Dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A) inhibitors: a survey of recent patent literature.Expert Opin Ther Pat. 2017 Nov;27(11):1183-1199. DMPA5WD RU https://www.ncbi.nlm.nih.gov/pubmed/28766366 DMPA5WD DI DMPA5WD DMPA5WD DN Harmine DMPA5WD MI TTV4EX0 DMPA5WD MN Dual-specificity tyrosine-phosphorylation regulated kinase 3 (DYRK3) DMPA5WD MT DTT DMPA5WD MA Inhibitor DMPA5WD RN Dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A) inhibitors: a survey of recent patent literature.Expert Opin Ther Pat. 2017 Nov;27(11):1183-1199. DMPA5WD RU https://www.ncbi.nlm.nih.gov/pubmed/28766366 DMPA5WD DI DMPA5WD DMPA5WD DN Harmine DMPA5WD MI TT3WG5C DMPA5WD MN Monoamine oxidase type A (MAO-A) DMPA5WD MT DTT DMPA5WD MA Inhibitor DMPA5WD RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DMPA5WD RU https://pubmed.ncbi.nlm.nih.gov/10592235 DMI732U DI DMI732U DMI732U DN Heteroaromatic ring derivative 1 DMI732U MI TTSCIM2 DMI732U MN Extracellular lysophospholipase D (E-NPP2) DMI732U MT DTT DMI732U MA Inhibitor DMI732U RN Autotaxin inhibitors: a patent review (2012-2016).Expert Opin Ther Pat. 2017 Jul;27(7):815-829. DMI732U RU https://www.ncbi.nlm.nih.gov/pubmed/28447479 DM5YD4W DI DM5YD4W DM5YD4W DN Heteroaromatic ring derivative 2 DM5YD4W MI TTSCIM2 DM5YD4W MN Extracellular lysophospholipase D (E-NPP2) DM5YD4W MT DTT DM5YD4W MA Inhibitor DM5YD4W RN Autotaxin inhibitors: a patent review (2012-2016).Expert Opin Ther Pat. 2017 Jul;27(7):815-829. DM5YD4W RU https://www.ncbi.nlm.nih.gov/pubmed/28447479 DMKJL5T DI DMKJL5T DMKJL5T DN Heteroaromatic ring derivative 3 DMKJL5T MI TTSCIM2 DMKJL5T MN Extracellular lysophospholipase D (E-NPP2) DMKJL5T MT DTT DMKJL5T MA Inhibitor DMKJL5T RN Autotaxin inhibitors: a patent review (2012-2016).Expert Opin Ther Pat. 2017 Jul;27(7):815-829. DMKJL5T RU https://www.ncbi.nlm.nih.gov/pubmed/28447479 DM9IL5Q DI DM9IL5Q DM9IL5Q DN Heteroaromatic ring derivative 4 DM9IL5Q MI TTSCIM2 DM9IL5Q MN Extracellular lysophospholipase D (E-NPP2) DM9IL5Q MT DTT DM9IL5Q MA Inhibitor DM9IL5Q RN Autotaxin inhibitors: a patent review (2012-2016).Expert Opin Ther Pat. 2017 Jul;27(7):815-829. DM9IL5Q RU https://www.ncbi.nlm.nih.gov/pubmed/28447479 DMDOQKY DI DMDOQKY DMDOQKY DN Heteroaryl-azepine derivative 1 DMDOQKY MI TTWJBZ5 DMDOQKY MN 5-HT 2C receptor (HTR2C) DMDOQKY MT DTT DMDOQKY MA Agonist DMDOQKY RN Novel serotonin receptor 2 (5-HT2R) agonists and antagonists: a patent review (2004-2014).Expert Opin Ther Pat. 2016;26(1):89-106. DMDOQKY RU https://www.ncbi.nlm.nih.gov/pubmed/26609882 DMMZ8LE DI DMMZ8LE DMMZ8LE DN Heteroaryl-azepine derivative 10 DMMZ8LE MI TTWJBZ5 DMMZ8LE MN 5-HT 2C receptor (HTR2C) DMMZ8LE MT DTT DMMZ8LE MA Agonist DMMZ8LE RN Novel serotonin receptor 2 (5-HT2R) agonists and antagonists: a patent review (2004-2014).Expert Opin Ther Pat. 2016;26(1):89-106. DMMZ8LE RU https://www.ncbi.nlm.nih.gov/pubmed/26609882 DM5BF6H DI DM5BF6H DM5BF6H DN Heteroaryl-azepine derivative 11 DM5BF6H MI TTWJBZ5 DM5BF6H MN 5-HT 2C receptor (HTR2C) DM5BF6H MT DTT DM5BF6H MA Agonist DM5BF6H RN Novel serotonin receptor 2 (5-HT2R) agonists and antagonists: a patent review (2004-2014).Expert Opin Ther Pat. 2016;26(1):89-106. DM5BF6H RU https://www.ncbi.nlm.nih.gov/pubmed/26609882 DMOG72B DI DMOG72B DMOG72B DN Heteroaryl-azepine derivative 12 DMOG72B MI TTWJBZ5 DMOG72B MN 5-HT 2C receptor (HTR2C) DMOG72B MT DTT DMOG72B MA Agonist DMOG72B RN Novel serotonin receptor 2 (5-HT2R) agonists and antagonists: a patent review (2004-2014).Expert Opin Ther Pat. 2016;26(1):89-106. DMOG72B RU https://www.ncbi.nlm.nih.gov/pubmed/26609882 DME86DP DI DME86DP DME86DP DN Heteroaryl-azepine derivative 13 DME86DP MI TTWJBZ5 DME86DP MN 5-HT 2C receptor (HTR2C) DME86DP MT DTT DME86DP MA Agonist DME86DP RN Novel serotonin receptor 2 (5-HT2R) agonists and antagonists: a patent review (2004-2014).Expert Opin Ther Pat. 2016;26(1):89-106. DME86DP RU https://www.ncbi.nlm.nih.gov/pubmed/26609882 DMG1TIF DI DMG1TIF DMG1TIF DN Heteroaryl-azepine derivative 14 DMG1TIF MI TTWJBZ5 DMG1TIF MN 5-HT 2C receptor (HTR2C) DMG1TIF MT DTT DMG1TIF MA Agonist DMG1TIF RN Novel serotonin receptor 2 (5-HT2R) agonists and antagonists: a patent review (2004-2014).Expert Opin Ther Pat. 2016;26(1):89-106. DMG1TIF RU https://www.ncbi.nlm.nih.gov/pubmed/26609882 DMS3WEJ DI DMS3WEJ DMS3WEJ DN Heteroaryl-azepine derivative 15 DMS3WEJ MI TTWJBZ5 DMS3WEJ MN 5-HT 2C receptor (HTR2C) DMS3WEJ MT DTT DMS3WEJ MA Agonist DMS3WEJ RN Novel serotonin receptor 2 (5-HT2R) agonists and antagonists: a patent review (2004-2014).Expert Opin Ther Pat. 2016;26(1):89-106. DMS3WEJ RU https://www.ncbi.nlm.nih.gov/pubmed/26609882 DMDFL6B DI DMDFL6B DMDFL6B DN Heteroaryl-azepine derivative 2 DMDFL6B MI TTWJBZ5 DMDFL6B MN 5-HT 2C receptor (HTR2C) DMDFL6B MT DTT DMDFL6B MA Agonist DMDFL6B RN Novel serotonin receptor 2 (5-HT2R) agonists and antagonists: a patent review (2004-2014).Expert Opin Ther Pat. 2016;26(1):89-106. DMDFL6B RU https://www.ncbi.nlm.nih.gov/pubmed/26609882 DMG14E3 DI DMG14E3 DMG14E3 DN Heteroaryl-azepine derivative 3 DMG14E3 MI TTWJBZ5 DMG14E3 MN 5-HT 2C receptor (HTR2C) DMG14E3 MT DTT DMG14E3 MA Agonist DMG14E3 RN Novel serotonin receptor 2 (5-HT2R) agonists and antagonists: a patent review (2004-2014).Expert Opin Ther Pat. 2016;26(1):89-106. DMG14E3 RU https://www.ncbi.nlm.nih.gov/pubmed/26609882 DMZVLH2 DI DMZVLH2 DMZVLH2 DN Heteroaryl-azepine derivative 4 DMZVLH2 MI TTWJBZ5 DMZVLH2 MN 5-HT 2C receptor (HTR2C) DMZVLH2 MT DTT DMZVLH2 MA Agonist DMZVLH2 RN Novel serotonin receptor 2 (5-HT2R) agonists and antagonists: a patent review (2004-2014).Expert Opin Ther Pat. 2016;26(1):89-106. DMZVLH2 RU https://www.ncbi.nlm.nih.gov/pubmed/26609882 DMON5RD DI DMON5RD DMON5RD DN Heteroaryl-azepine derivative 5 DMON5RD MI TTWJBZ5 DMON5RD MN 5-HT 2C receptor (HTR2C) DMON5RD MT DTT DMON5RD MA Agonist DMON5RD RN Novel serotonin receptor 2 (5-HT2R) agonists and antagonists: a patent review (2004-2014).Expert Opin Ther Pat. 2016;26(1):89-106. DMON5RD RU https://www.ncbi.nlm.nih.gov/pubmed/26609882 DM3O7UG DI DM3O7UG DM3O7UG DN Heteroaryl-azepine derivative 6 DM3O7UG MI TTWJBZ5 DM3O7UG MN 5-HT 2C receptor (HTR2C) DM3O7UG MT DTT DM3O7UG MA Agonist DM3O7UG RN Novel serotonin receptor 2 (5-HT2R) agonists and antagonists: a patent review (2004-2014).Expert Opin Ther Pat. 2016;26(1):89-106. DM3O7UG RU https://www.ncbi.nlm.nih.gov/pubmed/26609882 DMS6HOG DI DMS6HOG DMS6HOG DN Heteroaryl-azepine derivative 7 DMS6HOG MI TTWJBZ5 DMS6HOG MN 5-HT 2C receptor (HTR2C) DMS6HOG MT DTT DMS6HOG MA Agonist DMS6HOG RN Novel serotonin receptor 2 (5-HT2R) agonists and antagonists: a patent review (2004-2014).Expert Opin Ther Pat. 2016;26(1):89-106. DMS6HOG RU https://www.ncbi.nlm.nih.gov/pubmed/26609882 DMBJH8N DI DMBJH8N DMBJH8N DN Heteroaryl-azepine derivative 8 DMBJH8N MI TTWJBZ5 DMBJH8N MN 5-HT 2C receptor (HTR2C) DMBJH8N MT DTT DMBJH8N MA Agonist DMBJH8N RN Novel serotonin receptor 2 (5-HT2R) agonists and antagonists: a patent review (2004-2014).Expert Opin Ther Pat. 2016;26(1):89-106. DMBJH8N RU https://www.ncbi.nlm.nih.gov/pubmed/26609882 DMUZR3X DI DMUZR3X DMUZR3X DN Heteroaryl-azepine derivative 9 DMUZR3X MI TTWJBZ5 DMUZR3X MN 5-HT 2C receptor (HTR2C) DMUZR3X MT DTT DMUZR3X MA Agonist DMUZR3X RN Novel serotonin receptor 2 (5-HT2R) agonists and antagonists: a patent review (2004-2014).Expert Opin Ther Pat. 2016;26(1):89-106. DMUZR3X RU https://www.ncbi.nlm.nih.gov/pubmed/26609882 DMPRF1K DI DMPRF1K DMPRF1K DN Heteroaryl-carboxamide derivative 1 DMPRF1K MI TTCZOF2 DMPRF1K MN Pyruvate dehydrogenase kinase 1 (PDHK1) DMPRF1K MT DTT DMPRF1K MA Inhibitor DMPRF1K RN PDK1 disruptors and modulators: a patent review.Expert Opin Ther Pat. 2015 May;25(5):513-37. DMPRF1K RU https://www.ncbi.nlm.nih.gov/pubmed/25684022 DMVTARK DI DMVTARK DMVTARK DN Heteroaryl-carboxamide derivative 10 DMVTARK MI TTCZOF2 DMVTARK MN Pyruvate dehydrogenase kinase 1 (PDHK1) DMVTARK MT DTT DMVTARK MA Inhibitor DMVTARK RN PDK1 disruptors and modulators: a patent review.Expert Opin Ther Pat. 2015 May;25(5):513-37. DMVTARK RU https://www.ncbi.nlm.nih.gov/pubmed/25684022 DM1CWU7 DI DM1CWU7 DM1CWU7 DN Heteroaryl-carboxamide derivative 11 DM1CWU7 MI TT5L2VC DM1CWU7 MN Kallikrein-related peptidase (KLK) DM1CWU7 MT DTT DM1CWU7 MA Inhibitor DM1CWU7 RN Serine protease inhibitors to treat inflammation: a patent review (2011-2016).Expert Opin Ther Pat. 2018 Feb;28(2):93-110. DM1CWU7 RU https://www.ncbi.nlm.nih.gov/pubmed/29171765 DMGEFIW DI DMGEFIW DMGEFIW DN Heteroaryl-carboxamide derivative 2 DMGEFIW MI TTCZOF2 DMGEFIW MN Pyruvate dehydrogenase kinase 1 (PDHK1) DMGEFIW MT DTT DMGEFIW MA Inhibitor DMGEFIW RN PDK1 disruptors and modulators: a patent review.Expert Opin Ther Pat. 2015 May;25(5):513-37. DMGEFIW RU https://www.ncbi.nlm.nih.gov/pubmed/25684022 DMBGTNM DI DMBGTNM DMBGTNM DN Heteroaryl-carboxamide derivative 3 DMBGTNM MI TTCZOF2 DMBGTNM MN Pyruvate dehydrogenase kinase 1 (PDHK1) DMBGTNM MT DTT DMBGTNM MA Inhibitor DMBGTNM RN PDK1 disruptors and modulators: a patent review.Expert Opin Ther Pat. 2015 May;25(5):513-37. DMBGTNM RU https://www.ncbi.nlm.nih.gov/pubmed/25684022 DMHUIXR DI DMHUIXR DMHUIXR DN Heteroaryl-carboxamide derivative 4 DMHUIXR MI TTCZOF2 DMHUIXR MN Pyruvate dehydrogenase kinase 1 (PDHK1) DMHUIXR MT DTT DMHUIXR MA Inhibitor DMHUIXR RN PDK1 disruptors and modulators: a patent review.Expert Opin Ther Pat. 2015 May;25(5):513-37. DMHUIXR RU https://www.ncbi.nlm.nih.gov/pubmed/25684022 DMMX6V4 DI DMMX6V4 DMMX6V4 DN Heteroaryl-carboxamide derivative 5 DMMX6V4 MI TTCZOF2 DMMX6V4 MN Pyruvate dehydrogenase kinase 1 (PDHK1) DMMX6V4 MT DTT DMMX6V4 MA Inhibitor DMMX6V4 RN PDK1 disruptors and modulators: a patent review.Expert Opin Ther Pat. 2015 May;25(5):513-37. DMMX6V4 RU https://www.ncbi.nlm.nih.gov/pubmed/25684022 DM9IPDU DI DM9IPDU DM9IPDU DN Heteroaryl-carboxamide derivative 6 DM9IPDU MI TTCZOF2 DM9IPDU MN Pyruvate dehydrogenase kinase 1 (PDHK1) DM9IPDU MT DTT DM9IPDU MA Inhibitor DM9IPDU RN PDK1 disruptors and modulators: a patent review.Expert Opin Ther Pat. 2015 May;25(5):513-37. DM9IPDU RU https://www.ncbi.nlm.nih.gov/pubmed/25684022 DMOAYEV DI DMOAYEV DMOAYEV DN Heteroaryl-carboxamide derivative 7 DMOAYEV MI TTCZOF2 DMOAYEV MN Pyruvate dehydrogenase kinase 1 (PDHK1) DMOAYEV MT DTT DMOAYEV MA Inhibitor DMOAYEV RN PDK1 disruptors and modulators: a patent review.Expert Opin Ther Pat. 2015 May;25(5):513-37. DMOAYEV RU https://www.ncbi.nlm.nih.gov/pubmed/25684022 DMJTN91 DI DMJTN91 DMJTN91 DN Heteroaryl-carboxamide derivative 8 DMJTN91 MI TTCZOF2 DMJTN91 MN Pyruvate dehydrogenase kinase 1 (PDHK1) DMJTN91 MT DTT DMJTN91 MA Inhibitor DMJTN91 RN PDK1 disruptors and modulators: a patent review.Expert Opin Ther Pat. 2015 May;25(5):513-37. DMJTN91 RU https://www.ncbi.nlm.nih.gov/pubmed/25684022 DMI627Z DI DMI627Z DMI627Z DN Heteroaryl-carboxamide derivative 9 DMI627Z MI TTCZOF2 DMI627Z MN Pyruvate dehydrogenase kinase 1 (PDHK1) DMI627Z MT DTT DMI627Z MA Inhibitor DMI627Z RN PDK1 disruptors and modulators: a patent review.Expert Opin Ther Pat. 2015 May;25(5):513-37. DMI627Z RU https://www.ncbi.nlm.nih.gov/pubmed/25684022 DMRF58Q DI DMRF58Q DMRF58Q DN Heteroaryl-cyclopropylamine derivative 1 DMRF58Q MI TTNR0UQ DMRF58Q MN Lysine-specific histone demethylase 1 (LSD) DMRF58Q MT DTT DMRF58Q MA Inhibitor DMRF58Q RN LSD1 inhibitors: a patent review (2010-2015).Expert Opin Ther Pat. 2016 May;26(5):565-80. DMRF58Q RU https://www.ncbi.nlm.nih.gov/pubmed/27019002 DMRF58Q DI DMRF58Q DMRF58Q DN Heteroaryl-cyclopropylamine derivative 1 DMRF58Q MI TT3WG5C DMRF58Q MN Monoamine oxidase type A (MAO-A) DMRF58Q MT DTT DMRF58Q MA Inhibitor DMRF58Q RN LSD1 inhibitors: a patent review (2010-2015).Expert Opin Ther Pat. 2016 May;26(5):565-80. DMRF58Q RU https://www.ncbi.nlm.nih.gov/pubmed/27019002 DMRF58Q DI DMRF58Q DMRF58Q DN Heteroaryl-cyclopropylamine derivative 1 DMRF58Q MI TTGP7BY DMRF58Q MN Monoamine oxidase type B (MAO-B) DMRF58Q MT DTT DMRF58Q MA Inhibitor DMRF58Q RN LSD1 inhibitors: a patent review (2010-2015).Expert Opin Ther Pat. 2016 May;26(5):565-80. DMRF58Q RU https://www.ncbi.nlm.nih.gov/pubmed/27019002 DM9NE5T DI DM9NE5T DM9NE5T DN Heteroaryl-cyclopropylamine derivative 2 DM9NE5T MI TTNR0UQ DM9NE5T MN Lysine-specific histone demethylase 1 (LSD) DM9NE5T MT DTT DM9NE5T MA Inhibitor DM9NE5T RN LSD1 inhibitors: a patent review (2010-2015).Expert Opin Ther Pat. 2016 May;26(5):565-80. DM9NE5T RU https://www.ncbi.nlm.nih.gov/pubmed/27019002 DMH9EQ1 DI DMH9EQ1 DMH9EQ1 DN Heteroaryl-cyclopropylamine derivative 3 DMH9EQ1 MI TTNR0UQ DMH9EQ1 MN Lysine-specific histone demethylase 1 (LSD) DMH9EQ1 MT DTT DMH9EQ1 MA Inhibitor DMH9EQ1 RN LSD1 inhibitors: a patent review (2010-2015).Expert Opin Ther Pat. 2016 May;26(5):565-80. DMH9EQ1 RU https://www.ncbi.nlm.nih.gov/pubmed/27019002 DMH9EQ1 DI DMH9EQ1 DMH9EQ1 DN Heteroaryl-cyclopropylamine derivative 3 DMH9EQ1 MI TTGP7BY DMH9EQ1 MN Monoamine oxidase type B (MAO-B) DMH9EQ1 MT DTT DMH9EQ1 MA Inhibitor DMH9EQ1 RN LSD1 inhibitors: a patent review (2010-2015).Expert Opin Ther Pat. 2016 May;26(5):565-80. DMH9EQ1 RU https://www.ncbi.nlm.nih.gov/pubmed/27019002 DMMU01R DI DMMU01R DMMU01R DN Heteroaryl-cyclopropylamine derivative 4 DMMU01R MI TTZHPB8 DMMU01R MN Lysine-specific demethylase 4A (KDM4A) DMMU01R MT DTT DMMU01R MA Inhibitor DMMU01R RN LSD1 inhibitors: a patent review (2010-2015).Expert Opin Ther Pat. 2016 May;26(5):565-80. DMMU01R RU https://www.ncbi.nlm.nih.gov/pubmed/27019002 DMMU01R DI DMMU01R DMMU01R DN Heteroaryl-cyclopropylamine derivative 4 DMMU01R MI TTNR0UQ DMMU01R MN Lysine-specific histone demethylase 1 (LSD) DMMU01R MT DTT DMMU01R MA Inhibitor DMMU01R RN LSD1 inhibitors: a patent review (2010-2015).Expert Opin Ther Pat. 2016 May;26(5):565-80. DMMU01R RU https://www.ncbi.nlm.nih.gov/pubmed/27019002 DM9LQCH DI DM9LQCH DM9LQCH DN Heteroaryl-pyrazole derivative 1 DM9LQCH MI TTXJ47W DM9LQCH MN Metabotropic glutamate receptor 2 (mGluR2) DM9LQCH MT DTT DM9LQCH MA Antagonist DM9LQCH RN Novel metabotropic glutamate receptor 2/3 antagonists and their therapeutic applications: a patent review (2005 - present).Expert Opin Ther Pat. 2015 Jan;25(1):69-90. DM9LQCH RU https://www.ncbi.nlm.nih.gov/pubmed/25435285 DMIG0TQ DI DMIG0TQ DMIG0TQ DN Heteroaryl-pyrazole derivative 2 DMIG0TQ MI TTXJ47W DMIG0TQ MN Metabotropic glutamate receptor 2 (mGluR2) DMIG0TQ MT DTT DMIG0TQ MA Antagonist DMIG0TQ RN Novel metabotropic glutamate receptor 2/3 antagonists and their therapeutic applications: a patent review (2005 - present).Expert Opin Ther Pat. 2015 Jan;25(1):69-90. DMIG0TQ RU https://www.ncbi.nlm.nih.gov/pubmed/25435285 DMO45G3 DI DMO45G3 DMO45G3 DN Heteroaryl-pyrazole derivative 3 DMO45G3 MI TTXJ47W DMO45G3 MN Metabotropic glutamate receptor 2 (mGluR2) DMO45G3 MT DTT DMO45G3 MA Antagonist DMO45G3 RN Novel metabotropic glutamate receptor 2/3 antagonists and their therapeutic applications: a patent review (2005 - present).Expert Opin Ther Pat. 2015 Jan;25(1):69-90. DMO45G3 RU https://www.ncbi.nlm.nih.gov/pubmed/25435285 DM2BM1L DI DM2BM1L DM2BM1L DN Heteroaryl-substituted urea derivative 1 DM2BM1L MI TTDP1UC DM2BM1L MN Fatty acid amide hydrolase (FAAH) DM2BM1L MT DTT DM2BM1L MA Inhibitor DM2BM1L RN Fatty acid amide hydrolase inhibitors: a patent review (2009-2014).Expert Opin Ther Pat. 2015;25(11):1247-66. DM2BM1L RU https://www.ncbi.nlm.nih.gov/pubmed/26413912 DMHFQLC DI DMHFQLC DMHFQLC DN Heteroaryl-substituted urea derivative 2 DMHFQLC MI TTDP1UC DMHFQLC MN Fatty acid amide hydrolase (FAAH) DMHFQLC MT DTT DMHFQLC MA Inhibitor DMHFQLC RN Fatty acid amide hydrolase inhibitors: a patent review (2009-2014).Expert Opin Ther Pat. 2015;25(11):1247-66. DMHFQLC RU https://www.ncbi.nlm.nih.gov/pubmed/26413912 DM8PHBG DI DM8PHBG DM8PHBG DN Heterocycle-containing compound 1 DM8PHBG MI TT9O6WS DM8PHBG MN Glucagon receptor (GCGR) DM8PHBG MT DTT DM8PHBG MA Antagonist DM8PHBG RN Small molecule glucagon receptor antagonists: a patent review (2011 - 2014).Expert Opin Ther Pat. 2015 Jul;25(7):819-30. DM8PHBG RU https://www.ncbi.nlm.nih.gov/pubmed/25828189 DM2KVMT DI DM2KVMT DM2KVMT DN Heterocycle-containing compound 2 DM2KVMT MI TT9O6WS DM2KVMT MN Glucagon receptor (GCGR) DM2KVMT MT DTT DM2KVMT MA Antagonist DM2KVMT RN Small molecule glucagon receptor antagonists: a patent review (2011 - 2014).Expert Opin Ther Pat. 2015 Jul;25(7):819-30. DM2KVMT RU https://www.ncbi.nlm.nih.gov/pubmed/25828189 DMHMTF7 DI DMHMTF7 DMHMTF7 DN Heterocycle-containing compound 3 DMHMTF7 MI TT9O6WS DMHMTF7 MN Glucagon receptor (GCGR) DMHMTF7 MT DTT DMHMTF7 MA Antagonist DMHMTF7 RN Small molecule glucagon receptor antagonists: a patent review (2011 - 2014).Expert Opin Ther Pat. 2015 Jul;25(7):819-30. DMHMTF7 RU https://www.ncbi.nlm.nih.gov/pubmed/25828189 DM6IRJL DI DM6IRJL DM6IRJL DN Heterocycle-containing compound 4 DM6IRJL MI TT9O6WS DM6IRJL MN Glucagon receptor (GCGR) DM6IRJL MT DTT DM6IRJL MA Antagonist DM6IRJL RN Small molecule glucagon receptor antagonists: a patent review (2011 - 2014).Expert Opin Ther Pat. 2015 Jul;25(7):819-30. DM6IRJL RU https://www.ncbi.nlm.nih.gov/pubmed/25828189 DM6EY5Z DI DM6EY5Z DM6EY5Z DN Heterocycle-containing compound 5 DM6EY5Z MI TT9O6WS DM6EY5Z MN Glucagon receptor (GCGR) DM6EY5Z MT DTT DM6EY5Z MA Antagonist DM6EY5Z RN Small molecule glucagon receptor antagonists: a patent review (2011 - 2014).Expert Opin Ther Pat. 2015 Jul;25(7):819-30. DM6EY5Z RU https://www.ncbi.nlm.nih.gov/pubmed/25828189 DMJ5X46 DI DMJ5X46 DMJ5X46 DN Heterocyclic derivative 1 DMJ5X46 MI TTHS256 DMJ5X46 MN Metabotropic glutamate receptor 5 (mGluR5) DMJ5X46 MT DTT DMJ5X46 MA Modulator DMJ5X46 RN mGlu5 negative allosteric modulators: a patent review (2013 - 2016).Expert Opin Ther Pat. 2017 Jun;27(6):691-706. DMJ5X46 RU https://www.ncbi.nlm.nih.gov/pubmed/28067079 DMN580F DI DMN580F DMN580F DN Heterocyclic derivative 10 DMN580F MI TTCZOF2 DMN580F MN Pyruvate dehydrogenase kinase 1 (PDHK1) DMN580F MT DTT DMN580F MA Inhibitor DMN580F RN PDK1 disruptors and modulators: a patent review.Expert Opin Ther Pat. 2015 May;25(5):513-37. DMN580F RU https://www.ncbi.nlm.nih.gov/pubmed/25684022 DMUOI92 DI DMUOI92 DMUOI92 DN Heterocyclic derivative 11 DMUOI92 MI TTCZOF2 DMUOI92 MN Pyruvate dehydrogenase kinase 1 (PDHK1) DMUOI92 MT DTT DMUOI92 MA Inhibitor DMUOI92 RN PDK1 disruptors and modulators: a patent review.Expert Opin Ther Pat. 2015 May;25(5):513-37. DMUOI92 RU https://www.ncbi.nlm.nih.gov/pubmed/25684022 DMQJW9R DI DMQJW9R DMQJW9R DN Heterocyclic derivative 12 DMQJW9R MI TTCZOF2 DMQJW9R MN Pyruvate dehydrogenase kinase 1 (PDHK1) DMQJW9R MT DTT DMQJW9R MA Inhibitor DMQJW9R RN PDK1 disruptors and modulators: a patent review.Expert Opin Ther Pat. 2015 May;25(5):513-37. DMQJW9R RU https://www.ncbi.nlm.nih.gov/pubmed/25684022 DMWOBHM DI DMWOBHM DMWOBHM DN Heterocyclic derivative 13 DMWOBHM MI TTCZOF2 DMWOBHM MN Pyruvate dehydrogenase kinase 1 (PDHK1) DMWOBHM MT DTT DMWOBHM MA Inhibitor DMWOBHM RN PDK1 disruptors and modulators: a patent review.Expert Opin Ther Pat. 2015 May;25(5):513-37. DMWOBHM RU https://www.ncbi.nlm.nih.gov/pubmed/25684022 DMJ0WVR DI DMJ0WVR DMJ0WVR DN Heterocyclic derivative 14 DMJ0WVR MI TTCZOF2 DMJ0WVR MN Pyruvate dehydrogenase kinase 1 (PDHK1) DMJ0WVR MT DTT DMJ0WVR MA Inhibitor DMJ0WVR RN PDK1 disruptors and modulators: a patent review.Expert Opin Ther Pat. 2015 May;25(5):513-37. DMJ0WVR RU https://www.ncbi.nlm.nih.gov/pubmed/25684022 DMWZNDO DI DMWZNDO DMWZNDO DN Heterocyclic derivative 15 DMWZNDO MI TTCZOF2 DMWZNDO MN Pyruvate dehydrogenase kinase 1 (PDHK1) DMWZNDO MT DTT DMWZNDO MA Inhibitor DMWZNDO RN PDK1 disruptors and modulators: a patent review.Expert Opin Ther Pat. 2015 May;25(5):513-37. DMWZNDO RU https://www.ncbi.nlm.nih.gov/pubmed/25684022 DM6NJV7 DI DM6NJV7 DM6NJV7 DN Heterocyclic derivative 16 DM6NJV7 MI TTCZOF2 DM6NJV7 MN Pyruvate dehydrogenase kinase 1 (PDHK1) DM6NJV7 MT DTT DM6NJV7 MA Inhibitor DM6NJV7 RN PDK1 disruptors and modulators: a patent review.Expert Opin Ther Pat. 2015 May;25(5):513-37. DM6NJV7 RU https://www.ncbi.nlm.nih.gov/pubmed/25684022 DMD1K7E DI DMD1K7E DMD1K7E DN Heterocyclic derivative 17 DMD1K7E MI TTCZOF2 DMD1K7E MN Pyruvate dehydrogenase kinase 1 (PDHK1) DMD1K7E MT DTT DMD1K7E MA Inhibitor DMD1K7E RN PDK1 disruptors and modulators: a patent review.Expert Opin Ther Pat. 2015 May;25(5):513-37. DMD1K7E RU https://www.ncbi.nlm.nih.gov/pubmed/25684022 DMFUEDL DI DMFUEDL DMFUEDL DN Heterocyclic derivative 18 DMFUEDL MI TTCZOF2 DMFUEDL MN Pyruvate dehydrogenase kinase 1 (PDHK1) DMFUEDL MT DTT DMFUEDL MA Inhibitor DMFUEDL RN PDK1 disruptors and modulators: a patent review.Expert Opin Ther Pat. 2015 May;25(5):513-37. DMFUEDL RU https://www.ncbi.nlm.nih.gov/pubmed/25684022 DMNG0WH DI DMNG0WH DMNG0WH DN Heterocyclic derivative 19 DMNG0WH MI TTCZOF2 DMNG0WH MN Pyruvate dehydrogenase kinase 1 (PDHK1) DMNG0WH MT DTT DMNG0WH MA Inhibitor DMNG0WH RN PDK1 disruptors and modulators: a patent review.Expert Opin Ther Pat. 2015 May;25(5):513-37. DMNG0WH RU https://www.ncbi.nlm.nih.gov/pubmed/25684022 DM2QCBF DI DM2QCBF DM2QCBF DN Heterocyclic derivative 2 DM2QCBF MI TTHS256 DM2QCBF MN Metabotropic glutamate receptor 5 (mGluR5) DM2QCBF MT DTT DM2QCBF MA Modulator DM2QCBF RN mGlu5 negative allosteric modulators: a patent review (2013 - 2016).Expert Opin Ther Pat. 2017 Jun;27(6):691-706. DM2QCBF RU https://www.ncbi.nlm.nih.gov/pubmed/28067079 DM56T1P DI DM56T1P DM56T1P DN Heterocyclic derivative 26 DM56T1P MI TTIXKA4 DM56T1P MN Ribosomal protein S6 kinase alpha-1 (RSK1) DM56T1P MT DTT DM56T1P MA Inhibitor DM56T1P RN Ribosomal S6 kinase (RSK) modulators: a patent review.Expert Opin Ther Pat. 2016 Sep;26(9):1061-78. DM56T1P RU https://www.ncbi.nlm.nih.gov/pubmed/27410995 DMCD0MS DI DMCD0MS DMCD0MS DN Heterocyclic derivative 3 DMCD0MS MI TTHS256 DMCD0MS MN Metabotropic glutamate receptor 5 (mGluR5) DMCD0MS MT DTT DMCD0MS MA Modulator DMCD0MS RN mGlu5 negative allosteric modulators: a patent review (2013 - 2016).Expert Opin Ther Pat. 2017 Jun;27(6):691-706. DMCD0MS RU https://www.ncbi.nlm.nih.gov/pubmed/28067079 DM7VP8M DI DM7VP8M DM7VP8M DN Heterocyclic derivative 4 DM7VP8M MI TTCZOF2 DM7VP8M MN Pyruvate dehydrogenase kinase 1 (PDHK1) DM7VP8M MT DTT DM7VP8M MA Inhibitor DM7VP8M RN PDK1 disruptors and modulators: a patent review.Expert Opin Ther Pat. 2015 May;25(5):513-37. DM7VP8M RU https://www.ncbi.nlm.nih.gov/pubmed/25684022 DMWJDEO DI DMWJDEO DMWJDEO DN Heterocyclic derivative 5 DMWJDEO MI TTCZOF2 DMWJDEO MN Pyruvate dehydrogenase kinase 1 (PDHK1) DMWJDEO MT DTT DMWJDEO MA Inhibitor DMWJDEO RN PDK1 disruptors and modulators: a patent review.Expert Opin Ther Pat. 2015 May;25(5):513-37. DMWJDEO RU https://www.ncbi.nlm.nih.gov/pubmed/25684022 DM6HWN3 DI DM6HWN3 DM6HWN3 DN Heterocyclic derivative 6 DM6HWN3 MI TTCZOF2 DM6HWN3 MN Pyruvate dehydrogenase kinase 1 (PDHK1) DM6HWN3 MT DTT DM6HWN3 MA Inhibitor DM6HWN3 RN PDK1 disruptors and modulators: a patent review.Expert Opin Ther Pat. 2015 May;25(5):513-37. DM6HWN3 RU https://www.ncbi.nlm.nih.gov/pubmed/25684022 DMU6LS4 DI DMU6LS4 DMU6LS4 DN Heterocyclic derivative 7 DMU6LS4 MI TTCZOF2 DMU6LS4 MN Pyruvate dehydrogenase kinase 1 (PDHK1) DMU6LS4 MT DTT DMU6LS4 MA Inhibitor DMU6LS4 RN PDK1 disruptors and modulators: a patent review.Expert Opin Ther Pat. 2015 May;25(5):513-37. DMU6LS4 RU https://www.ncbi.nlm.nih.gov/pubmed/25684022 DMKPSIA DI DMKPSIA DMKPSIA DN Heterocyclic derivative 8 DMKPSIA MI TTCZOF2 DMKPSIA MN Pyruvate dehydrogenase kinase 1 (PDHK1) DMKPSIA MT DTT DMKPSIA MA Inhibitor DMKPSIA RN PDK1 disruptors and modulators: a patent review.Expert Opin Ther Pat. 2015 May;25(5):513-37. DMKPSIA RU https://www.ncbi.nlm.nih.gov/pubmed/25684022 DMY4LB7 DI DMY4LB7 DMY4LB7 DN Heterocyclic derivative 9 DMY4LB7 MI TTCZOF2 DMY4LB7 MN Pyruvate dehydrogenase kinase 1 (PDHK1) DMY4LB7 MT DTT DMY4LB7 MA Inhibitor DMY4LB7 RN PDK1 disruptors and modulators: a patent review.Expert Opin Ther Pat. 2015 May;25(5):513-37. DMY4LB7 RU https://www.ncbi.nlm.nih.gov/pubmed/25684022 DMA91IJ DI DMA91IJ DMA91IJ DN Heterocyclic-carboxamide derivative 1 DMA91IJ MI TTCZOF2 DMA91IJ MN Pyruvate dehydrogenase kinase 1 (PDHK1) DMA91IJ MT DTT DMA91IJ MA Inhibitor DMA91IJ RN PDK1 disruptors and modulators: a patent review.Expert Opin Ther Pat. 2015 May;25(5):513-37. DMA91IJ RU https://www.ncbi.nlm.nih.gov/pubmed/25684022 DMSQK50 DI DMSQK50 DMSQK50 DN Heterocyclic-carboxamide derivative 2 DMSQK50 MI TTCZOF2 DMSQK50 MN Pyruvate dehydrogenase kinase 1 (PDHK1) DMSQK50 MT DTT DMSQK50 MA Inhibitor DMSQK50 RN PDK1 disruptors and modulators: a patent review.Expert Opin Ther Pat. 2015 May;25(5):513-37. DMSQK50 RU https://www.ncbi.nlm.nih.gov/pubmed/25684022 DMEGK3Q DI DMEGK3Q DMEGK3Q DN Heterocyclic-fused piperazine derivative 1 DMEGK3Q MI TT473XN DMEGK3Q MN P2X purinoceptor 7 (P2RX7) DMEGK3Q MT DTT DMEGK3Q MA Antagonist DMEGK3Q RN P2X7 receptor antagonists: a patent review (2010-2015).Expert Opin Ther Pat. 2017 Mar;27(3):257-267. DMEGK3Q RU https://www.ncbi.nlm.nih.gov/pubmed/27724045 DMJEX3D DI DMJEX3D DMJEX3D DN Heterocyclic-substituted 3-alkyl azetidine derivative 1 DMJEX3D MI TT6OEDT DMJEX3D MN Cannabinoid receptor 1 (CB1) DMJEX3D MT DTT DMJEX3D MA Antagonist DMJEX3D RN A comprehensive patents review on cannabinoid 1 receptor antagonists as antiobesity agents. Expert Opin Ther Pat. 2015 Oct;25(10):1093-116. DMJEX3D RU https://pubmed.ncbi.nlm.nih.gov/26161824 DMEX7PV DI DMEX7PV DMEX7PV DN Heterocyclic-substituted 3-alkyl azetidine derivative 2 DMEX7PV MI TT6OEDT DMEX7PV MN Cannabinoid receptor 1 (CB1) DMEX7PV MT DTT DMEX7PV MA Antagonist DMEX7PV RN A comprehensive patents review on cannabinoid 1 receptor antagonists as antiobesity agents. Expert Opin Ther Pat. 2015 Oct;25(10):1093-116. DMEX7PV RU https://pubmed.ncbi.nlm.nih.gov/26161824 DMO1Y30 DI DMO1Y30 DMO1Y30 DN Heterocyclic-substituted 3-alkyl azetidine derivative 3 DMO1Y30 MI TT6OEDT DMO1Y30 MN Cannabinoid receptor 1 (CB1) DMO1Y30 MT DTT DMO1Y30 MA Antagonist DMO1Y30 RN A comprehensive patents review on cannabinoid 1 receptor antagonists as antiobesity agents. Expert Opin Ther Pat. 2015 Oct;25(10):1093-116. DMO1Y30 RU https://pubmed.ncbi.nlm.nih.gov/26161824 DMNJVR6 DI DMNJVR6 DMNJVR6 DN Heterocyclic-tetracyclic tetrahydrofuran derivative 1 DMNJVR6 MI TTYSN63 DMNJVR6 MN 5-HT 2 receptor (5HT2R) DMNJVR6 MT DTT DMNJVR6 MA Antagonist DMNJVR6 RN Novel serotonin receptor 2 (5-HT2R) agonists and antagonists: a patent review (2004-2014).Expert Opin Ther Pat. 2016;26(1):89-106. DMNJVR6 RU https://www.ncbi.nlm.nih.gov/pubmed/26609882 DMC1ZIX DI DMC1ZIX DMC1ZIX DN Hexahydro azepinone derivative 1 DMC1ZIX MI TTMQO60 DMC1ZIX MN Rho-associated protein kinase (ROCK) DMC1ZIX MT DTT DMC1ZIX MA Inhibitor DMC1ZIX RN Rho kinase inhibitors: a patent review (2014 - 2016).Expert Opin Ther Pat. 2017 Apr;27(4):507-515. DMC1ZIX RU https://www.ncbi.nlm.nih.gov/pubmed/28048944 DMT2Z0I DI DMT2Z0I DMT2Z0I DN Hexahydro naphthalene derivative 1 DMT2Z0I MI TTPADOQ DMT2Z0I MN HMG-CoA reductase (HMGCR) DMT2Z0I MT DTT DMT2Z0I MA Inhibitor DMT2Z0I RN HMG-CoA Reductase inhibitors: an updated review of patents of novel compounds and formulations (2011-2015).Expert Opin Ther Pat. 2016 Nov;26(11):1257-1272. DMT2Z0I RU https://www.ncbi.nlm.nih.gov/pubmed/27537201 DMFG9HP DI DMFG9HP DMFG9HP DN Hexahydro naphthalene derivative 2 DMFG9HP MI TTPADOQ DMFG9HP MN HMG-CoA reductase (HMGCR) DMFG9HP MT DTT DMFG9HP MA Inhibitor DMFG9HP RN HMG-CoA Reductase inhibitors: an updated review of patents of novel compounds and formulations (2011-2015).Expert Opin Ther Pat. 2016 Nov;26(11):1257-1272. DMFG9HP RU https://www.ncbi.nlm.nih.gov/pubmed/27537201 DM1KT4I DI DM1KT4I DM1KT4I DN Hexahydro naphthalene derivative 3 DM1KT4I MI TTPADOQ DM1KT4I MN HMG-CoA reductase (HMGCR) DM1KT4I MT DTT DM1KT4I MA Inhibitor DM1KT4I RN HMG-CoA Reductase inhibitors: an updated review of patents of novel compounds and formulations (2011-2015).Expert Opin Ther Pat. 2016 Nov;26(11):1257-1272. DM1KT4I RU https://www.ncbi.nlm.nih.gov/pubmed/27537201 DM4VNWX DI DM4VNWX DM4VNWX DN Hexahydro quinoline derivative 1 DM4VNWX MI TTZJYKH DM4VNWX MN Indoleamine 2,3-dioxygenase 1 (IDO1) DM4VNWX MT DTT DM4VNWX MA Inhibitor DM4VNWX RN A patent review of IDO1 inhibitors for cancer.Expert Opin Ther Pat. 2018 Apr;28(4):317-330. DM4VNWX RU https://www.ncbi.nlm.nih.gov/pubmed/29473428 DMU5JC0 DI DMU5JC0 DMU5JC0 DN HouttuynoidA DMU5JC0 MI TT3WG5C DMU5JC0 MN Monoamine oxidase type A (MAO-A) DMU5JC0 MT DTT DMU5JC0 MA Inhibitor DMU5JC0 RN Novel monoamine oxidase inhibitors: a patent review (2012 - 2014).Expert Opin Ther Pat. 2015 Jan;25(1):91-110. DMU5JC0 RU https://www.ncbi.nlm.nih.gov/pubmed/25399762 DMFIG8C DI DMFIG8C DMFIG8C DN Hydoxyamidine derivative 1 DMFIG8C MI TTZJYKH DMFIG8C MN Indoleamine 2,3-dioxygenase 1 (IDO1) DMFIG8C MT DTT DMFIG8C MA Inhibitor DMFIG8C RN A patent review of IDO1 inhibitors for cancer.Expert Opin Ther Pat. 2018 Apr;28(4):317-330. DMFIG8C RU https://www.ncbi.nlm.nih.gov/pubmed/29473428 DMUA740 DI DMUA740 DMUA740 DN Hydrazide derivative 1 DMUA740 MI TT6OEDT DMUA740 MN Cannabinoid receptor 1 (CB1) DMUA740 MT DTT DMUA740 MA Antagonist DMUA740 RN A comprehensive patents review on cannabinoid 1 receptor antagonists as antiobesity agents. Expert Opin Ther Pat. 2015 Oct;25(10):1093-116. DMUA740 RU https://pubmed.ncbi.nlm.nih.gov/26161824 DM3U79M DI DM3U79M DM3U79M DN Hydrazide derivative 3 DM3U79M MI TTK0FEA DM3U79M MN Leucine-rich repeat kinase 2 (LRRK2) DM3U79M MT DTT DM3U79M MA Inhibitor DM3U79M RN Leucine-rich repeat kinase 2 inhibitors: a patent review (2014-2016).Expert Opin Ther Pat. 2017 Jun;27(6):667-676. DM3U79M RU https://www.ncbi.nlm.nih.gov/pubmed/28117607 DM1HI8Q DI DM1HI8Q DM1HI8Q DN Hydrazide derivative 4 DM1HI8Q MI TTK0FEA DM1HI8Q MN Leucine-rich repeat kinase 2 (LRRK2) DM1HI8Q MT DTT DM1HI8Q MA Inhibitor DM1HI8Q RN Leucine-rich repeat kinase 2 inhibitors: a patent review (2014-2016).Expert Opin Ther Pat. 2017 Jun;27(6):667-676. DM1HI8Q RU https://www.ncbi.nlm.nih.gov/pubmed/28117607 DM6RLVB DI DM6RLVB DM6RLVB DN Hydrazide derivative 5 DM6RLVB MI TTK0FEA DM6RLVB MN Leucine-rich repeat kinase 2 (LRRK2) DM6RLVB MT DTT DM6RLVB MA Inhibitor DM6RLVB RN Leucine-rich repeat kinase 2 inhibitors: a patent review (2014-2016).Expert Opin Ther Pat. 2017 Jun;27(6):667-676. DM6RLVB RU https://www.ncbi.nlm.nih.gov/pubmed/28117607 DMEQBTO DI DMEQBTO DMEQBTO DN Hydrazinoacetic acid DMEQBTO MI TTLQUZS DMEQBTO MN Cystathionine gamma-lyase (CTH) DMEQBTO MT DTT DMEQBTO MA Inhibitor DMEQBTO RN Cystathionine--lyase (CSE) inhibitors. US9725426. DMEQBTO RU http://www.freepatentsonline.com/US9725426.html DMGATHZ DI DMGATHZ DMGATHZ DN Hydroxamate analog 1 DMGATHZ MI TTZHPB8 DMGATHZ MN Lysine-specific demethylase 4A (KDM4A) DMGATHZ MT DTT DMGATHZ MA Inhibitor DMGATHZ RN KDM4 histone demethylase inhibitors for anti-cancer agents: a patent review.Expert Opin Ther Pat. 2015 Feb;25(2):135-44. DMGATHZ RU https://www.ncbi.nlm.nih.gov/pubmed/25468267 DMGATHZ DI DMGATHZ DMGATHZ DN Hydroxamate analog 1 DMGATHZ MI TTV8CRH DMGATHZ MN Lysine-specific demethylase 4C (KDM4C) DMGATHZ MT DTT DMGATHZ MA Inhibitor DMGATHZ RN KDM4 histone demethylase inhibitors for anti-cancer agents: a patent review.Expert Opin Ther Pat. 2015 Feb;25(2):135-44. DMGATHZ RU https://www.ncbi.nlm.nih.gov/pubmed/25468267 DMBMG1S DI DMBMG1S DMBMG1S DN Hydroxamate analog 2 DMBMG1S MI TT0RGE9 DMBMG1S MN Lysine-specific demethylase 4 (KDM4) DMBMG1S MT DTT DMBMG1S MA Inhibitor DMBMG1S RN KDM4 histone demethylase inhibitors for anti-cancer agents: a patent review.Expert Opin Ther Pat. 2015 Feb;25(2):135-44. DMBMG1S RU https://www.ncbi.nlm.nih.gov/pubmed/25468267 DMDQYJ1 DI DMDQYJ1 DMDQYJ1 DN Hydroxamate analog 3 DMDQYJ1 MI TT0RGE9 DMDQYJ1 MN Lysine-specific demethylase 4 (KDM4) DMDQYJ1 MT DTT DMDQYJ1 MA Inhibitor DMDQYJ1 RN KDM4 histone demethylase inhibitors for anti-cancer agents: a patent review.Expert Opin Ther Pat. 2015 Feb;25(2):135-44. DMDQYJ1 RU https://www.ncbi.nlm.nih.gov/pubmed/25468267 DMBHIL2 DI DMBHIL2 DMBHIL2 DN Hydroxy amidine derivative 1 DMBHIL2 MI TTZJYKH DMBHIL2 MN Indoleamine 2,3-dioxygenase 1 (IDO1) DMBHIL2 MT DTT DMBHIL2 MA Inhibitor DMBHIL2 RN A patent review of IDO1 inhibitors for cancer.Expert Opin Ther Pat. 2018 Apr;28(4):317-330. DMBHIL2 RU https://www.ncbi.nlm.nih.gov/pubmed/29473428 DM7SUFJ DI DM7SUFJ DM7SUFJ DN Hydroxy amidine derivative 2 DM7SUFJ MI TTZJYKH DM7SUFJ MN Indoleamine 2,3-dioxygenase 1 (IDO1) DM7SUFJ MT DTT DM7SUFJ MA Inhibitor DM7SUFJ RN A patent review of IDO1 inhibitors for cancer.Expert Opin Ther Pat. 2018 Apr;28(4):317-330. DM7SUFJ RU https://www.ncbi.nlm.nih.gov/pubmed/29473428 DMAJFDT DI DMAJFDT DMAJFDT DN Hydroxyqunoline analog 1 DMAJFDT MI TTWAQBO DMAJFDT MN Lysine-specific demethylase 4E (KDM4E) DMAJFDT MT DTT DMAJFDT MA Inhibitor DMAJFDT RN KDM4 histone demethylase inhibitors for anti-cancer agents: a patent review.Expert Opin Ther Pat. 2015 Feb;25(2):135-44. DMAJFDT RU https://www.ncbi.nlm.nih.gov/pubmed/25468267 DMX3TZ7 DI DMX3TZ7 DMX3TZ7 DN Hydroxyqunoline analog 2 DMX3TZ7 MI TTWAQBO DMX3TZ7 MN Lysine-specific demethylase 4E (KDM4E) DMX3TZ7 MT DTT DMX3TZ7 MA Inhibitor DMX3TZ7 RN KDM4 histone demethylase inhibitors for anti-cancer agents: a patent review.Expert Opin Ther Pat. 2015 Feb;25(2):135-44. DMX3TZ7 RU https://www.ncbi.nlm.nih.gov/pubmed/25468267 DMCMKIL DI DMCMKIL DMCMKIL DN Hydroxyqunoline analog 3 DMCMKIL MI TTWAQBO DMCMKIL MN Lysine-specific demethylase 4E (KDM4E) DMCMKIL MT DTT DMCMKIL MA Inhibitor DMCMKIL RN KDM4 histone demethylase inhibitors for anti-cancer agents: a patent review.Expert Opin Ther Pat. 2015 Feb;25(2):135-44. DMCMKIL RU https://www.ncbi.nlm.nih.gov/pubmed/25468267 DMGQMCZ DI DMGQMCZ DMGQMCZ DN Hydroxyqunoline analog 4 DMGQMCZ MI TTWAQBO DMGQMCZ MN Lysine-specific demethylase 4E (KDM4E) DMGQMCZ MT DTT DMGQMCZ MA Inhibitor DMGQMCZ RN KDM4 histone demethylase inhibitors for anti-cancer agents: a patent review.Expert Opin Ther Pat. 2015 Feb;25(2):135-44. DMGQMCZ RU https://www.ncbi.nlm.nih.gov/pubmed/25468267 DM5QAKR DI DM5QAKR DM5QAKR DN Hydroxyqunoline analog 5 DM5QAKR MI TTWAQBO DM5QAKR MN Lysine-specific demethylase 4E (KDM4E) DM5QAKR MT DTT DM5QAKR MA Inhibitor DM5QAKR RN KDM4 histone demethylase inhibitors for anti-cancer agents: a patent review.Expert Opin Ther Pat. 2015 Feb;25(2):135-44. DM5QAKR RU https://www.ncbi.nlm.nih.gov/pubmed/25468267 DMMFI5G DI DMMFI5G DMMFI5G DN Hypersulfated disaccharide compound 1 DMMFI5G MI TTPLTSQ DMMFI5G MN Neutrophil elastase (NE) DMMFI5G MT DTT DMMFI5G MA Inhibitor DMMFI5G RN Neutrophil elastase inhibitors: a patent review and potential applications for inflammatory lung diseases (2010 - 2014).Expert Opin Ther Pat. 2015;25(10):1145-58. DMMFI5G RU https://www.ncbi.nlm.nih.gov/pubmed/26118988 DMMJTUW DI DMMJTUW DMMJTUW DN Imatinib and nilotinib derivative 1 DMMJTUW MI TTUNARX DMMJTUW MN Carbonic anhydrase (CA) DMMJTUW MT DTT DMMJTUW MA Inhibitor DMMJTUW RN Carbonic anhydrase inhibitors as antitumor/antimetastatic agents: a patent review (2008-2018).Expert Opin Ther Pat. 2018 Oct;28(10):729-740. DMMJTUW RU https://www.ncbi.nlm.nih.gov/pubmed/30074415 DM34NZ8 DI DM34NZ8 DM34NZ8 DN Imatinib and nilotinib derivative 2 DM34NZ8 MI TTUNARX DM34NZ8 MN Carbonic anhydrase (CA) DM34NZ8 MT DTT DM34NZ8 MA Inhibitor DM34NZ8 RN Carbonic anhydrase inhibitors as antitumor/antimetastatic agents: a patent review (2008-2018).Expert Opin Ther Pat. 2018 Oct;28(10):729-740. DM34NZ8 RU https://www.ncbi.nlm.nih.gov/pubmed/30074415 DMWUFKO DI DMWUFKO DMWUFKO DN Imidamide derivative 1 DMWUFKO MI TT3M2WO DMWUFKO MN Sphingosine kinase (SphK) DMWUFKO MT DTT DMWUFKO MA Inhibitor DMWUFKO RN Sphingosine kinase inhibitors: a review of patent literature (2006-2015).Expert Opin Ther Pat. 2016 Dec;26(12):1409-1416. DMWUFKO RU https://www.ncbi.nlm.nih.gov/pubmed/27539678 DMWABOJ DI DMWABOJ DMWABOJ DN Imidazo [1,2-a]pyridine compound 1 DMWABOJ MI TTUX68I DMWABOJ MN Hypoxia-inducible factor 1 (HIF-1) DMWABOJ MT DTT DMWABOJ MA Inhibitor DMWABOJ RN Hypoxia-inducible factor (HIF) inhibitors: a patent survey (2011-2015).Expert Opin Ther Pat. 2016;26(3):309-22. DMWABOJ RU https://www.ncbi.nlm.nih.gov/pubmed/26882240 DM01RXU DI DM01RXU DM01RXU DN Imidazo bicyclic iminium derivative 1 DM01RXU MI TTJOMH6 DM01RXU MN Zinc finger protein GLI1 (Gli1) DM01RXU MT DTT DM01RXU MA Inhibitor DM01RXU RN Evaluation of WO2014207069 A1: Multitarget Hedgehog pathway inhibitors and uses thereof.Expert Opin Ther Pat. 2016;26(4):529-35. DM01RXU RU https://www.ncbi.nlm.nih.gov/pubmed/26666870 DMA7DI6 DI DMA7DI6 DMA7DI6 DN Imidazo bicyclic iminium derivative 2 DMA7DI6 MI TTJOMH6 DMA7DI6 MN Zinc finger protein GLI1 (Gli1) DMA7DI6 MT DTT DMA7DI6 MA Inhibitor DMA7DI6 RN Evaluation of WO2014207069 A1: Multitarget Hedgehog pathway inhibitors and uses thereof.Expert Opin Ther Pat. 2016;26(4):529-35. DMA7DI6 RU https://www.ncbi.nlm.nih.gov/pubmed/26666870 DMENYZ0 DI DMENYZ0 DMENYZ0 DN Imidazo bicyclic iminium derivative 3 DMENYZ0 MI TT8J1S3 DMENYZ0 MN Smoothened homolog (SMO) DMENYZ0 MT DTT DMENYZ0 MA Inhibitor DMENYZ0 RN Hedgehog inhibitors: a patent review (2013 - present).Expert Opin Ther Pat. 2015 May;25(5):549-65. DMENYZ0 RU https://www.ncbi.nlm.nih.gov/pubmed/25726713 DMHRV8J DI DMHRV8J DMHRV8J DN Imidazo bicyclic iminium derivative 4 DMHRV8J MI TT8J1S3 DMHRV8J MN Smoothened homolog (SMO) DMHRV8J MT DTT DMHRV8J MA Inhibitor DMHRV8J RN Hedgehog inhibitors: a patent review (2013 - present).Expert Opin Ther Pat. 2015 May;25(5):549-65. DMHRV8J RU https://www.ncbi.nlm.nih.gov/pubmed/25726713 DMS8GIU DI DMS8GIU DMS8GIU DN Imidazo bicyclic iminium derivative 5 DMS8GIU MI TT8J1S3 DMS8GIU MN Smoothened homolog (SMO) DMS8GIU MT DTT DMS8GIU MA Inhibitor DMS8GIU RN Hedgehog inhibitors: a patent review (2013 - present).Expert Opin Ther Pat. 2015 May;25(5):549-65. DMS8GIU RU https://www.ncbi.nlm.nih.gov/pubmed/25726713 DMEP5MJ DI DMEP5MJ DMEP5MJ DN Imidazo bicyclic iminium derivative 6 DMEP5MJ MI TT8J1S3 DMEP5MJ MN Smoothened homolog (SMO) DMEP5MJ MT DTT DMEP5MJ MA Inhibitor DMEP5MJ RN Hedgehog inhibitors: a patent review (2013 - present).Expert Opin Ther Pat. 2015 May;25(5):549-65. DMEP5MJ RU https://www.ncbi.nlm.nih.gov/pubmed/25726713 DM0Y4X8 DI DM0Y4X8 DM0Y4X8 DN Imidazo bicyclic iminium derivative 7 DM0Y4X8 MI TT8J1S3 DM0Y4X8 MN Smoothened homolog (SMO) DM0Y4X8 MT DTT DM0Y4X8 MA Inhibitor DM0Y4X8 RN Hedgehog inhibitors: a patent review (2013 - present).Expert Opin Ther Pat. 2015 May;25(5):549-65. DM0Y4X8 RU https://www.ncbi.nlm.nih.gov/pubmed/25726713 DMBMFPC DI DMBMFPC DMBMFPC DN Imidazo bicyclic iminium derivative 8 DMBMFPC MI TT8J1S3 DMBMFPC MN Smoothened homolog (SMO) DMBMFPC MT DTT DMBMFPC MA Inhibitor DMBMFPC RN Hedgehog inhibitors: a patent review (2013 - present).Expert Opin Ther Pat. 2015 May;25(5):549-65. DMBMFPC RU https://www.ncbi.nlm.nih.gov/pubmed/25726713 DMQXCT1 DI DMQXCT1 DMQXCT1 DN Imidazo bicyclic iminium derivative 9 DMQXCT1 MI TT8J1S3 DMQXCT1 MN Smoothened homolog (SMO) DMQXCT1 MT DTT DMQXCT1 MA Inhibitor DMQXCT1 RN Hedgehog inhibitors: a patent review (2013 - present).Expert Opin Ther Pat. 2015 May;25(5):549-65. DMQXCT1 RU https://www.ncbi.nlm.nih.gov/pubmed/25726713 DM34ZCG DI DM34ZCG DM34ZCG DN Imidazo cyclohexylamine derivative 1 DM34ZCG MI TTDIGC1 DM34ZCG MN Dipeptidyl peptidase 4 (DPP-4) DM34ZCG MT DTT DM34ZCG MA Inhibitor DM34ZCG RN DPP-4 inhibitors: a patent review (2012 - 2014).Expert Opin Ther Pat. 2015 Feb;25(2):209-36. DM34ZCG RU https://www.ncbi.nlm.nih.gov/pubmed/25482888 DMKPAN3 DI DMKPAN3 DMKPAN3 DN Imidazo cyclohexylamine derivative 2 DMKPAN3 MI TTDIGC1 DMKPAN3 MN Dipeptidyl peptidase 4 (DPP-4) DMKPAN3 MT DTT DMKPAN3 MA Inhibitor DMKPAN3 RN DPP-4 inhibitors: a patent review (2012 - 2014).Expert Opin Ther Pat. 2015 Feb;25(2):209-36. DMKPAN3 RU https://www.ncbi.nlm.nih.gov/pubmed/25482888 DMCQBZK DI DMCQBZK DMCQBZK DN Imidazo cyclohexylamine derivative 3 DMCQBZK MI TTDIGC1 DMCQBZK MN Dipeptidyl peptidase 4 (DPP-4) DMCQBZK MT DTT DMCQBZK MA Inhibitor DMCQBZK RN DPP-4 inhibitors: a patent review (2012 - 2014).Expert Opin Ther Pat. 2015 Feb;25(2):209-36. DMCQBZK RU https://www.ncbi.nlm.nih.gov/pubmed/25482888 DM1JXKY DI DM1JXKY DM1JXKY DN Imidazo isoindole derivative 1 DM1JXKY MI TTZJYKH DM1JXKY MN Indoleamine 2,3-dioxygenase 1 (IDO1) DM1JXKY MT DTT DM1JXKY MA Inhibitor DM1JXKY RN A patent review of IDO1 inhibitors for cancer.Expert Opin Ther Pat. 2018 Apr;28(4):317-330. DM1JXKY RU https://www.ncbi.nlm.nih.gov/pubmed/29473428 DMCXHGW DI DMCXHGW DMCXHGW DN Imidazo pyridine derivative 1 DMCXHGW MI TTTDVOJ DMCXHGW MN Tropomyosin-related kinase A (TrkA) DMCXHGW MT DTT DMCXHGW MA Inhibitor DMCXHGW RN Tropomyosin receptor kinase inhibitors: an updated patent review for 2010-2016 - Part II.Expert Opin Ther Pat. 2017 Jul;27(7):831-849. DMCXHGW RU https://www.ncbi.nlm.nih.gov/pubmed/28270021 DMC49SV DI DMC49SV DMC49SV DN Imidazo pyridine derivative 2 DMC49SV MI TTDIGC1 DMC49SV MN Dipeptidyl peptidase 4 (DPP-4) DMC49SV MT DTT DMC49SV MA Inhibitor DMC49SV RN DPP-4 inhibitors: a patent review (2012 - 2014).Expert Opin Ther Pat. 2015 Feb;25(2):209-36. DMC49SV RU https://www.ncbi.nlm.nih.gov/pubmed/25482888 DMPCLZB DI DMPCLZB DMPCLZB DN Imidazo pyridine derivative 3 DMPCLZB MI TT0PG8F DMPCLZB MN Cyclin-dependent kinase 4 (CDK4) DMPCLZB MT DTT DMPCLZB MA Inhibitor DMPCLZB RN Cyclin-dependent kinase inhibitors for cancer therapy: a patent review (2009 - 2014).Expert Opin Ther Pat. 2015;25(9):953-70. DMPCLZB RU https://www.ncbi.nlm.nih.gov/pubmed/26161698 DM3YMHP DI DM3YMHP DM3YMHP DN Imidazo pyridine derivative 4 DM3YMHP MI TTV1C0Z DM3YMHP MN Neuropeptide S receptor (NPSR) DM3YMHP MT DTT DM3YMHP MA Antagonist DM3YMHP RN Neuropeptide S receptor ligands: a patent review (2005-2016).Expert Opin Ther Pat. 2017 Mar;27(3):347-362. DM3YMHP RU https://www.ncbi.nlm.nih.gov/pubmed/27788040 DMOVJ35 DI DMOVJ35 DMOVJ35 DN Imidazo pyridine derivative 5 DMOVJ35 MI TTV1C0Z DMOVJ35 MN Neuropeptide S receptor (NPSR) DMOVJ35 MT DTT DMOVJ35 MA Antagonist DMOVJ35 RN Neuropeptide S receptor ligands: a patent review (2005-2016).Expert Opin Ther Pat. 2017 Mar;27(3):347-362. DMOVJ35 RU https://www.ncbi.nlm.nih.gov/pubmed/27788040 DMG6W3O DI DMG6W3O DMG6W3O DN Imidazo pyridine derivative 6 DMG6W3O MI TTV1C0Z DMG6W3O MN Neuropeptide S receptor (NPSR) DMG6W3O MT DTT DMG6W3O MA Antagonist DMG6W3O RN Neuropeptide S receptor ligands: a patent review (2005-2016).Expert Opin Ther Pat. 2017 Mar;27(3):347-362. DMG6W3O RU https://www.ncbi.nlm.nih.gov/pubmed/27788040 DMGDMWA DI DMGDMWA DMGDMWA DN Imidazo quinoline derivative 1 DMGDMWA MI TTCZOF2 DMGDMWA MN Pyruvate dehydrogenase kinase 1 (PDHK1) DMGDMWA MT DTT DMGDMWA MA Inhibitor DMGDMWA RN PDK1 disruptors and modulators: a patent review.Expert Opin Ther Pat. 2015 May;25(5):513-37. DMGDMWA RU https://www.ncbi.nlm.nih.gov/pubmed/25684022 DMLVY7A DI DMLVY7A DMLVY7A DN Imidazo triazine derivative 1 DMLVY7A MI TTJGW1Z DMLVY7A MN Phosphodiesterase 2A (PDE2A) DMLVY7A MT DTT DMLVY7A MA Inhibitor DMLVY7A RN Towards selective phosphodiesterase 2A (PDE2A) inhibitors: a patent review (2010 - present).Expert Opin Ther Pat. 2016 Aug;26(8):933-46. DMLVY7A RU https://www.ncbi.nlm.nih.gov/pubmed/27321640 DMZFG68 DI DMZFG68 DMZFG68 DN Imidazo triazine derivative 2 DMZFG68 MI TTJGW1Z DMZFG68 MN Phosphodiesterase 2A (PDE2A) DMZFG68 MT DTT DMZFG68 MA Inhibitor DMZFG68 RN Towards selective phosphodiesterase 2A (PDE2A) inhibitors: a patent review (2010 - present).Expert Opin Ther Pat. 2016 Aug;26(8):933-46. DMZFG68 RU https://www.ncbi.nlm.nih.gov/pubmed/27321640 DM142HI DI DM142HI DM142HI DN Imidazo triazine derivative 3 DM142HI MI TTJGW1Z DM142HI MN Phosphodiesterase 2A (PDE2A) DM142HI MT DTT DM142HI MA Inhibitor DM142HI RN Towards selective phosphodiesterase 2A (PDE2A) inhibitors: a patent review (2010 - present).Expert Opin Ther Pat. 2016 Aug;26(8):933-46. DM142HI RU https://www.ncbi.nlm.nih.gov/pubmed/27321640 DMZTS2O DI DMZTS2O DMZTS2O DN Imidazo triazine derivative 4 DMZTS2O MI TTJGW1Z DMZTS2O MN Phosphodiesterase 2A (PDE2A) DMZTS2O MT DTT DMZTS2O MA Inhibitor DMZTS2O RN Towards selective phosphodiesterase 2A (PDE2A) inhibitors: a patent review (2010 - present).Expert Opin Ther Pat. 2016 Aug;26(8):933-46. DMZTS2O RU https://www.ncbi.nlm.nih.gov/pubmed/27321640 DM18P4N DI DM18P4N DM18P4N DN Imidazo triazine derivative 5 DM18P4N MI TTJGW1Z DM18P4N MN Phosphodiesterase 2A (PDE2A) DM18P4N MT DTT DM18P4N MA Inhibitor DM18P4N RN Towards selective phosphodiesterase 2A (PDE2A) inhibitors: a patent review (2010 - present).Expert Opin Ther Pat. 2016 Aug;26(8):933-46. DM18P4N RU https://www.ncbi.nlm.nih.gov/pubmed/27321640 DM5NEQ2 DI DM5NEQ2 DM5NEQ2 DN Imidazo[1,2-a]pyridine derivative 1 DM5NEQ2 MI TTHS256 DM5NEQ2 MN Metabotropic glutamate receptor 5 (mGluR5) DM5NEQ2 MT DTT DM5NEQ2 MA Modulator DM5NEQ2 RN mGlu5 negative allosteric modulators: a patent review (2013 - 2016).Expert Opin Ther Pat. 2017 Jun;27(6):691-706. DM5NEQ2 RU https://www.ncbi.nlm.nih.gov/pubmed/28067079 DM654Z0 DI DM654Z0 DM654Z0 DN Imidazo[1,2-b]pyridazine acetamide derivative 1 DM654Z0 MI TTPTXIN DM654Z0 MN Translocator protein (TSPO) DM654Z0 MT DTT DM654Z0 MA Ligand DM654Z0 RN Translocator protein (TSPO) ligands for the diagnosis or treatment of neurodegenerative diseases: a patent review (2010-2015; part 1).Expert Opin Ther Pat. 2016 Nov;26(11):1325-1351. DM654Z0 RU https://www.ncbi.nlm.nih.gov/pubmed/27607364 DMVX7YB DI DMVX7YB DMVX7YB DN Imidazo[1,2-b]pyridazine acetamide derivative 2 DMVX7YB MI TTPTXIN DMVX7YB MN Translocator protein (TSPO) DMVX7YB MT DTT DMVX7YB MA Ligand DMVX7YB RN Translocator protein (TSPO) ligands for the diagnosis or treatment of neurodegenerative diseases: a patent review (2010-2015; part 1).Expert Opin Ther Pat. 2016 Nov;26(11):1325-1351. DMVX7YB RU https://www.ncbi.nlm.nih.gov/pubmed/27607364 DMARLZ6 DI DMARLZ6 DMARLZ6 DN Imidazo[1,2-b]pyridazine acetamide derivative 3 DMARLZ6 MI TTPTXIN DMARLZ6 MN Translocator protein (TSPO) DMARLZ6 MT DTT DMARLZ6 MA Ligand DMARLZ6 RN Translocator protein (TSPO) ligands for the diagnosis or treatment of neurodegenerative diseases: a patent review (2010-2015; part 1).Expert Opin Ther Pat. 2016 Nov;26(11):1325-1351. DMARLZ6 RU https://www.ncbi.nlm.nih.gov/pubmed/27607364 DM5J09E DI DM5J09E DM5J09E DN Imidazo[1,2-b]pyridazine acetamide derivative 4 DM5J09E MI TTPTXIN DM5J09E MN Translocator protein (TSPO) DM5J09E MT DTT DM5J09E MA Ligand DM5J09E RN Translocator protein (TSPO) ligands for the diagnosis or treatment of neurodegenerative diseases: a patent review (2010-2015; part 1).Expert Opin Ther Pat. 2016 Nov;26(11):1325-1351. DM5J09E RU https://www.ncbi.nlm.nih.gov/pubmed/27607364 DMGWYJR DI DMGWYJR DMGWYJR DN Imidazo[1,2-b]pyridazine acetamide derivative 5 DMGWYJR MI TTPTXIN DMGWYJR MN Translocator protein (TSPO) DMGWYJR MT DTT DMGWYJR MA Ligand DMGWYJR RN Translocator protein (TSPO) ligands for the diagnosis or treatment of neurodegenerative diseases: a patent review (2010-2015; part 1).Expert Opin Ther Pat. 2016 Nov;26(11):1325-1351. DMGWYJR RU https://www.ncbi.nlm.nih.gov/pubmed/27607364 DM73ESA DI DM73ESA DM73ESA DN Imidazo[1,2-b]pyridazine acetamide derivative 6 DM73ESA MI TTPTXIN DM73ESA MN Translocator protein (TSPO) DM73ESA MT DTT DM73ESA MA Ligand DM73ESA RN Translocator protein (TSPO) ligands for the diagnosis or treatment of neurodegenerative diseases: a patent review (2010-2015; part 1).Expert Opin Ther Pat. 2016 Nov;26(11):1325-1351. DM73ESA RU https://www.ncbi.nlm.nih.gov/pubmed/27607364 DMQLJU2 DI DMQLJU2 DMQLJU2 DN Imidazo[1,2-b]pyridazine acetamide derivative 7 DMQLJU2 MI TTPTXIN DMQLJU2 MN Translocator protein (TSPO) DMQLJU2 MT DTT DMQLJU2 MA Ligand DMQLJU2 RN Translocator protein (TSPO) ligands for the diagnosis or treatment of neurodegenerative diseases: a patent review (2010-2015; part 1).Expert Opin Ther Pat. 2016 Nov;26(11):1325-1351. DMQLJU2 RU https://www.ncbi.nlm.nih.gov/pubmed/27607364 DMULTAI DI DMULTAI DMULTAI DN Imidazo[1,2-b]pyridazine derivative 1 DMULTAI MI TTSZ6Y3 DMULTAI MN Proto-oncogene c-Ros (ROS1) DMULTAI MT DTT DMULTAI MA Inhibitor DMULTAI RN Tropomyosin receptor kinase inhibitors: an updated patent review for 2010-2016 - Part I.Expert Opin Ther Pat. 2017 Jun;27(6):733-751. DMULTAI RU https://www.ncbi.nlm.nih.gov/pubmed/28270010 DMULTAI DI DMULTAI DMULTAI DN Imidazo[1,2-b]pyridazine derivative 1 DMULTAI MI TTTDVOJ DMULTAI MN Tropomyosin-related kinase A (TrkA) DMULTAI MT DTT DMULTAI MA Inhibitor DMULTAI RN Tropomyosin receptor kinase inhibitors: an updated patent review for 2010-2016 - Part I.Expert Opin Ther Pat. 2017 Jun;27(6):733-751. DMULTAI RU https://www.ncbi.nlm.nih.gov/pubmed/28270010 DM1JYNW DI DM1JYNW DM1JYNW DN Imidazo[1,2-b]pyridazine derivative 2 DM1JYNW MI TTSZ6Y3 DM1JYNW MN Proto-oncogene c-Ros (ROS1) DM1JYNW MT DTT DM1JYNW MA Inhibitor DM1JYNW RN Tropomyosin receptor kinase inhibitors: an updated patent review for 2010-2016 - Part I.Expert Opin Ther Pat. 2017 Jun;27(6):733-751. DM1JYNW RU https://www.ncbi.nlm.nih.gov/pubmed/28270010 DM1JYNW DI DM1JYNW DM1JYNW DN Imidazo[1,2-b]pyridazine derivative 2 DM1JYNW MI TTTDVOJ DM1JYNW MN Tropomyosin-related kinase A (TrkA) DM1JYNW MT DTT DM1JYNW MA Inhibitor DM1JYNW RN Tropomyosin receptor kinase inhibitors: an updated patent review for 2010-2016 - Part I.Expert Opin Ther Pat. 2017 Jun;27(6):733-751. DM1JYNW RU https://www.ncbi.nlm.nih.gov/pubmed/28270010 DMPDTG0 DI DMPDTG0 DMPDTG0 DN Imidazo[1,2-b]pyridazine derivative 3 DMPDTG0 MI TTSZ6Y3 DMPDTG0 MN Proto-oncogene c-Ros (ROS1) DMPDTG0 MT DTT DMPDTG0 MA Inhibitor DMPDTG0 RN Tropomyosin receptor kinase inhibitors: an updated patent review for 2010-2016 - Part I.Expert Opin Ther Pat. 2017 Jun;27(6):733-751. DMPDTG0 RU https://www.ncbi.nlm.nih.gov/pubmed/28270010 DMPDTG0 DI DMPDTG0 DMPDTG0 DN Imidazo[1,2-b]pyridazine derivative 3 DMPDTG0 MI TTTDVOJ DMPDTG0 MN Tropomyosin-related kinase A (TrkA) DMPDTG0 MT DTT DMPDTG0 MA Inhibitor DMPDTG0 RN Tropomyosin receptor kinase inhibitors: an updated patent review for 2010-2016 - Part I.Expert Opin Ther Pat. 2017 Jun;27(6):733-751. DMPDTG0 RU https://www.ncbi.nlm.nih.gov/pubmed/28270010 DM2DL4I DI DM2DL4I DM2DL4I DN Imidazo[1,2-b]pyridazine derivative 4 DM2DL4I MI TTTDVOJ DM2DL4I MN Tropomyosin-related kinase A (TrkA) DM2DL4I MT DTT DM2DL4I MA Inhibitor DM2DL4I RN Tropomyosin receptor kinase inhibitors: an updated patent review for 2010-2016 - Part I.Expert Opin Ther Pat. 2017 Jun;27(6):733-751. DM2DL4I RU https://www.ncbi.nlm.nih.gov/pubmed/28270010 DMK8V7A DI DMK8V7A DMK8V7A DN Imidazo[1,2-b]pyridazine derivative 5 DMK8V7A MI TTTDVOJ DMK8V7A MN Tropomyosin-related kinase A (TrkA) DMK8V7A MT DTT DMK8V7A MA Inhibitor DMK8V7A RN Tropomyosin receptor kinase inhibitors: an updated patent review for 2010-2016 - Part I.Expert Opin Ther Pat. 2017 Jun;27(6):733-751. DMK8V7A RU https://www.ncbi.nlm.nih.gov/pubmed/28270010 DMSIRC2 DI DMSIRC2 DMSIRC2 DN Imidazo[1,2-b]pyridazine derivative 6 DMSIRC2 MI TTTDVOJ DMSIRC2 MN Tropomyosin-related kinase A (TrkA) DMSIRC2 MT DTT DMSIRC2 MA Inhibitor DMSIRC2 RN Tropomyosin receptor kinase inhibitors: an updated patent review for 2010-2016 - Part I.Expert Opin Ther Pat. 2017 Jun;27(6):733-751. DMSIRC2 RU https://www.ncbi.nlm.nih.gov/pubmed/28270010 DMDQLUP DI DMDQLUP DMDQLUP DN Imidazo[1,2-b]pyridazine derivative 7 DMDQLUP MI TTTDVOJ DMDQLUP MN Tropomyosin-related kinase A (TrkA) DMDQLUP MT DTT DMDQLUP MA Inhibitor DMDQLUP RN Tropomyosin receptor kinase inhibitors: an updated patent review for 2010-2016 - Part I.Expert Opin Ther Pat. 2017 Jun;27(6):733-751. DMDQLUP RU https://www.ncbi.nlm.nih.gov/pubmed/28270010 DMFIP0D DI DMFIP0D DMFIP0D DN Imidazo[1,5-a]pyridine derivative 1 DMFIP0D MI TTZJYKH DMFIP0D MN Indoleamine 2,3-dioxygenase 1 (IDO1) DMFIP0D MT DTT DMFIP0D MA Inhibitor DMFIP0D RN A patent review of IDO1 inhibitors for cancer.Expert Opin Ther Pat. 2018 Apr;28(4):317-330. DMFIP0D RU https://www.ncbi.nlm.nih.gov/pubmed/29473428 DMU3PAR DI DMU3PAR DMU3PAR DN Imidazo[1,5-a]pyridine derivative 2 DMU3PAR MI TTZJYKH DMU3PAR MN Indoleamine 2,3-dioxygenase 1 (IDO1) DMU3PAR MT DTT DMU3PAR MA Inhibitor DMU3PAR RN A patent review of IDO1 inhibitors for cancer.Expert Opin Ther Pat. 2018 Apr;28(4):317-330. DMU3PAR RU https://www.ncbi.nlm.nih.gov/pubmed/29473428 DM4KBZQ DI DM4KBZQ DM4KBZQ DN Imidazo[4,5-c]pyridine derivative 1 DM4KBZQ MI TTKAWRQ DM4KBZQ MN JAK-STAT signaling pathway (JAK-STAT pathway) DM4KBZQ MT DTT DM4KBZQ MA Inhibitor DM4KBZQ RN Inhibitors of JAK-family kinases: an update on the patent literature 2013-2015, part 1.Expert Opin Ther Pat. 2017 Feb;27(2):127-143. DM4KBZQ RU https://www.ncbi.nlm.nih.gov/pubmed/27774824 DM4KBZQ DI DM4KBZQ DM4KBZQ DN Imidazo[4,5-c]pyridine derivative 1 DM4KBZQ MI TT6DM01 DM4KBZQ MN Janus kinase 1 (JAK-1) DM4KBZQ MT DTT DM4KBZQ MA Inhibitor DM4KBZQ RN Inhibitors of JAK-family kinases: an update on the patent literature 2013-2015, part 1.Expert Opin Ther Pat. 2017 Feb;27(2):127-143. DM4KBZQ RU https://www.ncbi.nlm.nih.gov/pubmed/27774824 DM4KBZQ DI DM4KBZQ DM4KBZQ DN Imidazo[4,5-c]pyridine derivative 1 DM4KBZQ MI TTT7PJU DM4KBZQ MN Janus kinase 3 (JAK-3) DM4KBZQ MT DTT DM4KBZQ MA Inhibitor DM4KBZQ RN Inhibitors of JAK-family kinases: an update on the patent literature 2013-2015, part 1.Expert Opin Ther Pat. 2017 Feb;27(2):127-143. DM4KBZQ RU https://www.ncbi.nlm.nih.gov/pubmed/27774824 DM4KBZQ DI DM4KBZQ DM4KBZQ DN Imidazo[4,5-c]pyridine derivative 1 DM4KBZQ MI TTBYWP2 DM4KBZQ MN TYK2 tyrosine kinase (TYK2) DM4KBZQ MT DTT DM4KBZQ MA Inhibitor DM4KBZQ RN Inhibitors of JAK-family kinases: an update on the patent literature 2013-2015, part 1.Expert Opin Ther Pat. 2017 Feb;27(2):127-143. DM4KBZQ RU https://www.ncbi.nlm.nih.gov/pubmed/27774824 DM4KBZQ DI DM4KBZQ DM4KBZQ DN Imidazo[4,5-c]pyridine derivative 1 DM4KBZQ MI TTJSQEF DM4KBZQ MN Tyrosine-protein kinase (PTK) DM4KBZQ MT DTT DM4KBZQ MA Inhibitor DM4KBZQ RN Inhibitors of JAK-family kinases: an update on the patent literature 2013-2015, part 1.Expert Opin Ther Pat. 2017 Feb;27(2):127-143. DM4KBZQ RU https://www.ncbi.nlm.nih.gov/pubmed/27774824 DMFDRJT DI DMFDRJT DMFDRJT DN Imidazo[4,5-c]pyridine derivative 2 DMFDRJT MI TTKAWRQ DMFDRJT MN JAK-STAT signaling pathway (JAK-STAT pathway) DMFDRJT MT DTT DMFDRJT MA Inhibitor DMFDRJT RN Inhibitors of JAK-family kinases: an update on the patent literature 2013-2015, part 1.Expert Opin Ther Pat. 2017 Feb;27(2):127-143. DMFDRJT RU https://www.ncbi.nlm.nih.gov/pubmed/27774824 DMFDRJT DI DMFDRJT DMFDRJT DN Imidazo[4,5-c]pyridine derivative 2 DMFDRJT MI TT6DM01 DMFDRJT MN Janus kinase 1 (JAK-1) DMFDRJT MT DTT DMFDRJT MA Inhibitor DMFDRJT RN Inhibitors of JAK-family kinases: an update on the patent literature 2013-2015, part 1.Expert Opin Ther Pat. 2017 Feb;27(2):127-143. DMFDRJT RU https://www.ncbi.nlm.nih.gov/pubmed/27774824 DMFDRJT DI DMFDRJT DMFDRJT DN Imidazo[4,5-c]pyridine derivative 2 DMFDRJT MI TTRMX3V DMFDRJT MN Janus kinase 2 (JAK-2) DMFDRJT MT DTT DMFDRJT MA Inhibitor DMFDRJT RN Inhibitors of JAK-family kinases: an update on the patent literature 2013-2015, part 1.Expert Opin Ther Pat. 2017 Feb;27(2):127-143. DMFDRJT RU https://www.ncbi.nlm.nih.gov/pubmed/27774824 DMFDRJT DI DMFDRJT DMFDRJT DN Imidazo[4,5-c]pyridine derivative 2 DMFDRJT MI TTT7PJU DMFDRJT MN Janus kinase 3 (JAK-3) DMFDRJT MT DTT DMFDRJT MA Inhibitor DMFDRJT RN Inhibitors of JAK-family kinases: an update on the patent literature 2013-2015, part 1.Expert Opin Ther Pat. 2017 Feb;27(2):127-143. DMFDRJT RU https://www.ncbi.nlm.nih.gov/pubmed/27774824 DMFDRJT DI DMFDRJT DMFDRJT DN Imidazo[4,5-c]pyridine derivative 2 DMFDRJT MI TTBYWP2 DMFDRJT MN TYK2 tyrosine kinase (TYK2) DMFDRJT MT DTT DMFDRJT MA Inhibitor DMFDRJT RN Inhibitors of JAK-family kinases: an update on the patent literature 2013-2015, part 1.Expert Opin Ther Pat. 2017 Feb;27(2):127-143. DMFDRJT RU https://www.ncbi.nlm.nih.gov/pubmed/27774824 DMFDRJT DI DMFDRJT DMFDRJT DN Imidazo[4,5-c]pyridine derivative 2 DMFDRJT MI TTJSQEF DMFDRJT MN Tyrosine-protein kinase (PTK) DMFDRJT MT DTT DMFDRJT MA Inhibitor DMFDRJT RN Inhibitors of JAK-family kinases: an update on the patent literature 2013-2015, part 1.Expert Opin Ther Pat. 2017 Feb;27(2):127-143. DMFDRJT RU https://www.ncbi.nlm.nih.gov/pubmed/27774824 DMUB4QL DI DMUB4QL DMUB4QL DN Imidazo[5,1-c][1,2,4]benzotriazine derivative 1 DMUB4QL MI TTJW4LU DMUB4QL MN Phosphodiesterase 10A (PDE10) DMUB4QL MT DTT DMUB4QL MA Inhibitor DMUB4QL RN Towards selective phosphodiesterase 2A (PDE2A) inhibitors: a patent review (2010 - present).Expert Opin Ther Pat. 2016 Aug;26(8):933-46. DMUB4QL RU https://www.ncbi.nlm.nih.gov/pubmed/27321640 DMUB4QL DI DMUB4QL DMUB4QL DN Imidazo[5,1-c][1,2,4]benzotriazine derivative 1 DMUB4QL MI TTJGW1Z DMUB4QL MN Phosphodiesterase 2A (PDE2A) DMUB4QL MT DTT DMUB4QL MA Inhibitor DMUB4QL RN Towards selective phosphodiesterase 2A (PDE2A) inhibitors: a patent review (2010 - present).Expert Opin Ther Pat. 2016 Aug;26(8):933-46. DMUB4QL RU https://www.ncbi.nlm.nih.gov/pubmed/27321640 DMB8AJP DI DMB8AJP DMB8AJP DN Imidazo[5,1-c][1,2,4]benzotriazine derivative 2 DMB8AJP MI TTJW4LU DMB8AJP MN Phosphodiesterase 10A (PDE10) DMB8AJP MT DTT DMB8AJP MA Inhibitor DMB8AJP RN Towards selective phosphodiesterase 2A (PDE2A) inhibitors: a patent review (2010 - present).Expert Opin Ther Pat. 2016 Aug;26(8):933-46. DMB8AJP RU https://www.ncbi.nlm.nih.gov/pubmed/27321640 DMB8AJP DI DMB8AJP DMB8AJP DN Imidazo[5,1-c][1,2,4]benzotriazine derivative 2 DMB8AJP MI TTJGW1Z DMB8AJP MN Phosphodiesterase 2A (PDE2A) DMB8AJP MT DTT DMB8AJP MA Inhibitor DMB8AJP RN Towards selective phosphodiesterase 2A (PDE2A) inhibitors: a patent review (2010 - present).Expert Opin Ther Pat. 2016 Aug;26(8):933-46. DMB8AJP RU https://www.ncbi.nlm.nih.gov/pubmed/27321640 DMYX684 DI DMYX684 DMYX684 DN Imidazo[5,1-c][1,2,4]benzotriazine derivative 3 DMYX684 MI TTJW4LU DMYX684 MN Phosphodiesterase 10A (PDE10) DMYX684 MT DTT DMYX684 MA Inhibitor DMYX684 RN Towards selective phosphodiesterase 2A (PDE2A) inhibitors: a patent review (2010 - present).Expert Opin Ther Pat. 2016 Aug;26(8):933-46. DMYX684 RU https://www.ncbi.nlm.nih.gov/pubmed/27321640 DMYX684 DI DMYX684 DMYX684 DN Imidazo[5,1-c][1,2,4]benzotriazine derivative 3 DMYX684 MI TTJGW1Z DMYX684 MN Phosphodiesterase 2A (PDE2A) DMYX684 MT DTT DMYX684 MA Inhibitor DMYX684 RN Towards selective phosphodiesterase 2A (PDE2A) inhibitors: a patent review (2010 - present).Expert Opin Ther Pat. 2016 Aug;26(8):933-46. DMYX684 RU https://www.ncbi.nlm.nih.gov/pubmed/27321640 DMWF4S7 DI DMWF4S7 DMWF4S7 DN Imidazo[5,1-c][1,2,4]benzotriazine derivative 4 DMWF4S7 MI TTJW4LU DMWF4S7 MN Phosphodiesterase 10A (PDE10) DMWF4S7 MT DTT DMWF4S7 MA Inhibitor DMWF4S7 RN Towards selective phosphodiesterase 2A (PDE2A) inhibitors: a patent review (2010 - present).Expert Opin Ther Pat. 2016 Aug;26(8):933-46. DMWF4S7 RU https://www.ncbi.nlm.nih.gov/pubmed/27321640 DMWF4S7 DI DMWF4S7 DMWF4S7 DN Imidazo[5,1-c][1,2,4]benzotriazine derivative 4 DMWF4S7 MI TTJGW1Z DMWF4S7 MN Phosphodiesterase 2A (PDE2A) DMWF4S7 MT DTT DMWF4S7 MA Inhibitor DMWF4S7 RN Towards selective phosphodiesterase 2A (PDE2A) inhibitors: a patent review (2010 - present).Expert Opin Ther Pat. 2016 Aug;26(8):933-46. DMWF4S7 RU https://www.ncbi.nlm.nih.gov/pubmed/27321640 DMQBH81 DI DMQBH81 DMQBH81 DN Imidazo[5,1-c]pyrido[2,3-e][1,2,4]triazine derivative 1 DMQBH81 MI TTJW4LU DMQBH81 MN Phosphodiesterase 10A (PDE10) DMQBH81 MT DTT DMQBH81 MA Inhibitor DMQBH81 RN Towards selective phosphodiesterase 2A (PDE2A) inhibitors: a patent review (2010 - present).Expert Opin Ther Pat. 2016 Aug;26(8):933-46. DMQBH81 RU https://www.ncbi.nlm.nih.gov/pubmed/27321640 DMQBH81 DI DMQBH81 DMQBH81 DN Imidazo[5,1-c]pyrido[2,3-e][1,2,4]triazine derivative 1 DMQBH81 MI TTJGW1Z DMQBH81 MN Phosphodiesterase 2A (PDE2A) DMQBH81 MT DTT DMQBH81 MA Inhibitor DMQBH81 RN Towards selective phosphodiesterase 2A (PDE2A) inhibitors: a patent review (2010 - present).Expert Opin Ther Pat. 2016 Aug;26(8):933-46. DMQBH81 RU https://www.ncbi.nlm.nih.gov/pubmed/27321640 DMS3ROL DI DMS3ROL DMS3ROL DN Imidazo[5,1-c]pyrido[2,3-e][1,2,4]triazine derivative 2 DMS3ROL MI TTJW4LU DMS3ROL MN Phosphodiesterase 10A (PDE10) DMS3ROL MT DTT DMS3ROL MA Inhibitor DMS3ROL RN Towards selective phosphodiesterase 2A (PDE2A) inhibitors: a patent review (2010 - present).Expert Opin Ther Pat. 2016 Aug;26(8):933-46. DMS3ROL RU https://www.ncbi.nlm.nih.gov/pubmed/27321640 DMS3ROL DI DMS3ROL DMS3ROL DN Imidazo[5,1-c]pyrido[2,3-e][1,2,4]triazine derivative 2 DMS3ROL MI TTJGW1Z DMS3ROL MN Phosphodiesterase 2A (PDE2A) DMS3ROL MT DTT DMS3ROL MA Inhibitor DMS3ROL RN Towards selective phosphodiesterase 2A (PDE2A) inhibitors: a patent review (2010 - present).Expert Opin Ther Pat. 2016 Aug;26(8):933-46. DMS3ROL RU https://www.ncbi.nlm.nih.gov/pubmed/27321640 DMZ61T8 DI DMZ61T8 DMZ61T8 DN Imidazo[5,1-c]pyrido[2,3-e][1,2,4]triazine derivative 3 DMZ61T8 MI TTJW4LU DMZ61T8 MN Phosphodiesterase 10A (PDE10) DMZ61T8 MT DTT DMZ61T8 MA Inhibitor DMZ61T8 RN Towards selective phosphodiesterase 2A (PDE2A) inhibitors: a patent review (2010 - present).Expert Opin Ther Pat. 2016 Aug;26(8):933-46. DMZ61T8 RU https://www.ncbi.nlm.nih.gov/pubmed/27321640 DMZ61T8 DI DMZ61T8 DMZ61T8 DN Imidazo[5,1-c]pyrido[2,3-e][1,2,4]triazine derivative 3 DMZ61T8 MI TTJGW1Z DMZ61T8 MN Phosphodiesterase 2A (PDE2A) DMZ61T8 MT DTT DMZ61T8 MA Inhibitor DMZ61T8 RN Towards selective phosphodiesterase 2A (PDE2A) inhibitors: a patent review (2010 - present).Expert Opin Ther Pat. 2016 Aug;26(8):933-46. DMZ61T8 RU https://www.ncbi.nlm.nih.gov/pubmed/27321640 DMKR5ZO DI DMKR5ZO DMKR5ZO DN Imidazo[5,1-c]pyrido[2,3-e][1,2,4]triazine derivative 4 DMKR5ZO MI TTJW4LU DMKR5ZO MN Phosphodiesterase 10A (PDE10) DMKR5ZO MT DTT DMKR5ZO MA Inhibitor DMKR5ZO RN Towards selective phosphodiesterase 2A (PDE2A) inhibitors: a patent review (2010 - present).Expert Opin Ther Pat. 2016 Aug;26(8):933-46. DMKR5ZO RU https://www.ncbi.nlm.nih.gov/pubmed/27321640 DMKR5ZO DI DMKR5ZO DMKR5ZO DN Imidazo[5,1-c]pyrido[2,3-e][1,2,4]triazine derivative 4 DMKR5ZO MI TTJGW1Z DMKR5ZO MN Phosphodiesterase 2A (PDE2A) DMKR5ZO MT DTT DMKR5ZO MA Inhibitor DMKR5ZO RN Towards selective phosphodiesterase 2A (PDE2A) inhibitors: a patent review (2010 - present).Expert Opin Ther Pat. 2016 Aug;26(8):933-46. DMKR5ZO RU https://www.ncbi.nlm.nih.gov/pubmed/27321640 DM7UAKH DI DM7UAKH DM7UAKH DN Imidazo[5,1-c]pyrido[2,3-e][1,2,4]triazine derivative 5 DM7UAKH MI TTJW4LU DM7UAKH MN Phosphodiesterase 10A (PDE10) DM7UAKH MT DTT DM7UAKH MA Inhibitor DM7UAKH RN Towards selective phosphodiesterase 2A (PDE2A) inhibitors: a patent review (2010 - present).Expert Opin Ther Pat. 2016 Aug;26(8):933-46. DM7UAKH RU https://www.ncbi.nlm.nih.gov/pubmed/27321640 DM7UAKH DI DM7UAKH DM7UAKH DN Imidazo[5,1-c]pyrido[2,3-e][1,2,4]triazine derivative 5 DM7UAKH MI TTJGW1Z DM7UAKH MN Phosphodiesterase 2A (PDE2A) DM7UAKH MT DTT DM7UAKH MA Inhibitor DM7UAKH RN Towards selective phosphodiesterase 2A (PDE2A) inhibitors: a patent review (2010 - present).Expert Opin Ther Pat. 2016 Aug;26(8):933-46. DM7UAKH RU https://www.ncbi.nlm.nih.gov/pubmed/27321640 DMKRUAN DI DMKRUAN DMKRUAN DN Imidazo[5,1-c]pyrido[2,3-e][1,2,4]triazine derivative 6 DMKRUAN MI TTJW4LU DMKRUAN MN Phosphodiesterase 10A (PDE10) DMKRUAN MT DTT DMKRUAN MA Inhibitor DMKRUAN RN Towards selective phosphodiesterase 2A (PDE2A) inhibitors: a patent review (2010 - present).Expert Opin Ther Pat. 2016 Aug;26(8):933-46. DMKRUAN RU https://www.ncbi.nlm.nih.gov/pubmed/27321640 DMKRUAN DI DMKRUAN DMKRUAN DN Imidazo[5,1-c]pyrido[2,3-e][1,2,4]triazine derivative 6 DMKRUAN MI TTJGW1Z DMKRUAN MN Phosphodiesterase 2A (PDE2A) DMKRUAN MT DTT DMKRUAN MA Inhibitor DMKRUAN RN Towards selective phosphodiesterase 2A (PDE2A) inhibitors: a patent review (2010 - present).Expert Opin Ther Pat. 2016 Aug;26(8):933-46. DMKRUAN RU https://www.ncbi.nlm.nih.gov/pubmed/27321640 DMINBJM DI DMINBJM DMINBJM DN Imidazo[5,1-c]pyrido[2,3-e][1,2,4]triazine derivative 7 DMINBJM MI TTJW4LU DMINBJM MN Phosphodiesterase 10A (PDE10) DMINBJM MT DTT DMINBJM MA Inhibitor DMINBJM RN Towards selective phosphodiesterase 2A (PDE2A) inhibitors: a patent review (2010 - present).Expert Opin Ther Pat. 2016 Aug;26(8):933-46. DMINBJM RU https://www.ncbi.nlm.nih.gov/pubmed/27321640 DMINBJM DI DMINBJM DMINBJM DN Imidazo[5,1-c]pyrido[2,3-e][1,2,4]triazine derivative 7 DMINBJM MI TTJGW1Z DMINBJM MN Phosphodiesterase 2A (PDE2A) DMINBJM MT DTT DMINBJM MA Inhibitor DMINBJM RN Towards selective phosphodiesterase 2A (PDE2A) inhibitors: a patent review (2010 - present).Expert Opin Ther Pat. 2016 Aug;26(8):933-46. DMINBJM RU https://www.ncbi.nlm.nih.gov/pubmed/27321640 DM42EST DI DM42EST DM42EST DN Imidazo[5,1-c]pyrido[2,3-e][1,2,4]triazine derivative 8 DM42EST MI TTJW4LU DM42EST MN Phosphodiesterase 10A (PDE10) DM42EST MT DTT DM42EST MA Inhibitor DM42EST RN Towards selective phosphodiesterase 2A (PDE2A) inhibitors: a patent review (2010 - present).Expert Opin Ther Pat. 2016 Aug;26(8):933-46. DM42EST RU https://www.ncbi.nlm.nih.gov/pubmed/27321640 DM42EST DI DM42EST DM42EST DN Imidazo[5,1-c]pyrido[2,3-e][1,2,4]triazine derivative 8 DM42EST MI TTJGW1Z DM42EST MN Phosphodiesterase 2A (PDE2A) DM42EST MT DTT DM42EST MA Inhibitor DM42EST RN Towards selective phosphodiesterase 2A (PDE2A) inhibitors: a patent review (2010 - present).Expert Opin Ther Pat. 2016 Aug;26(8):933-46. DM42EST RU https://www.ncbi.nlm.nih.gov/pubmed/27321640 DM0SOKJ DI DM0SOKJ DM0SOKJ DN Imidazole benzamide derivative 1 DM0SOKJ MI TTYLQ8V DM0SOKJ MN Prostaglandin E synthase (PTGES) DM0SOKJ MT DTT DM0SOKJ MA Inhibitor DM0SOKJ RN Microsomal prostaglandin E2 synthase-1 inhibitors: a patent review.Expert Opin Ther Pat. 2017 Sep;27(9):1047-1059. DM0SOKJ RU https://www.ncbi.nlm.nih.gov/pubmed/28627961 DM14KHX DI DM14KHX DM14KHX DN Imidazole derivative 1 DM14KHX MI TT6OEDT DM14KHX MN Cannabinoid receptor 1 (CB1) DM14KHX MT DTT DM14KHX MA Antagonist DM14KHX RN A comprehensive patents review on cannabinoid 1 receptor antagonists as antiobesity agents. Expert Opin Ther Pat. 2015 Oct;25(10):1093-116. DM14KHX RU https://pubmed.ncbi.nlm.nih.gov/26161824 DMI7W3K DI DMI7W3K DMI7W3K DN Imidazole derivative 10 DMI7W3K MI TTN9T81 DMI7W3K MN Arachidonate 15-lipoxygenase (15-LOX) DMI7W3K MT DTT DMI7W3K MA Inhibitor DMI7W3K RN 15-Lipoxygenase inhibitors: a patent review.Expert Opin Ther Pat. 2016;26(1):65-88. DMI7W3K RU https://www.ncbi.nlm.nih.gov/pubmed/26560362 DMTJ0DP DI DMTJ0DP DMTJ0DP DN Imidazole derivative 11 DMTJ0DP MI TTN9T81 DMTJ0DP MN Arachidonate 15-lipoxygenase (15-LOX) DMTJ0DP MT DTT DMTJ0DP MA Inhibitor DMTJ0DP RN 15-Lipoxygenase inhibitors: a patent review.Expert Opin Ther Pat. 2016;26(1):65-88. DMTJ0DP RU https://www.ncbi.nlm.nih.gov/pubmed/26560362 DM8GCVO DI DM8GCVO DM8GCVO DN Imidazole derivative 2 DM8GCVO MI TT6OEDT DM8GCVO MN Cannabinoid receptor 1 (CB1) DM8GCVO MT DTT DM8GCVO MA Antagonist DM8GCVO RN A comprehensive patents review on cannabinoid 1 receptor antagonists as antiobesity agents. Expert Opin Ther Pat. 2015 Oct;25(10):1093-116. DM8GCVO RU https://pubmed.ncbi.nlm.nih.gov/26161824 DMV1ER2 DI DMV1ER2 DMV1ER2 DN Imidazole derivative 3 DMV1ER2 MI TT6OEDT DMV1ER2 MN Cannabinoid receptor 1 (CB1) DMV1ER2 MT DTT DMV1ER2 MA Antagonist DMV1ER2 RN A comprehensive patents review on cannabinoid 1 receptor antagonists as antiobesity agents. Expert Opin Ther Pat. 2015 Oct;25(10):1093-116. DMV1ER2 RU https://pubmed.ncbi.nlm.nih.gov/26161824 DMPGMX2 DI DMPGMX2 DMPGMX2 DN Imidazole derivative 4 DMPGMX2 MI TT6OEDT DMPGMX2 MN Cannabinoid receptor 1 (CB1) DMPGMX2 MT DTT DMPGMX2 MA Antagonist DMPGMX2 RN A comprehensive patents review on cannabinoid 1 receptor antagonists as antiobesity agents. Expert Opin Ther Pat. 2015 Oct;25(10):1093-116. DMPGMX2 RU https://pubmed.ncbi.nlm.nih.gov/26161824 DMVSXUM DI DMVSXUM DMVSXUM DN Imidazole derivative 5 DMVSXUM MI TT6OEDT DMVSXUM MN Cannabinoid receptor 1 (CB1) DMVSXUM MT DTT DMVSXUM MA Antagonist DMVSXUM RN A comprehensive patents review on cannabinoid 1 receptor antagonists as antiobesity agents. Expert Opin Ther Pat. 2015 Oct;25(10):1093-116. DMVSXUM RU https://pubmed.ncbi.nlm.nih.gov/26161824 DMOXHZJ DI DMOXHZJ DMOXHZJ DN Imidazole derivative 6 DMOXHZJ MI TT6OEDT DMOXHZJ MN Cannabinoid receptor 1 (CB1) DMOXHZJ MT DTT DMOXHZJ MA Antagonist DMOXHZJ RN A comprehensive patents review on cannabinoid 1 receptor antagonists as antiobesity agents. Expert Opin Ther Pat. 2015 Oct;25(10):1093-116. DMOXHZJ RU https://pubmed.ncbi.nlm.nih.gov/26161824 DMLPQ7E DI DMLPQ7E DMLPQ7E DN Imidazole derivative 7 DMLPQ7E MI TT6OEDT DMLPQ7E MN Cannabinoid receptor 1 (CB1) DMLPQ7E MT DTT DMLPQ7E MA Antagonist DMLPQ7E RN A comprehensive patents review on cannabinoid 1 receptor antagonists as antiobesity agents. Expert Opin Ther Pat. 2015 Oct;25(10):1093-116. DMLPQ7E RU https://pubmed.ncbi.nlm.nih.gov/26161824 DMK9P7S DI DMK9P7S DMK9P7S DN Imidazole derivative 8 DMK9P7S MI TTTJZ4M DMK9P7S MN Prolylcarboxypeptidase (PRCP) DMK9P7S MT DTT DMK9P7S MA Inhibitor DMK9P7S RN Prolylcarboxypeptidase (PrCP) inhibitors and the therapeutic uses thereof: a patent review.Expert Opin Ther Pat. 2017 Oct;27(10):1077-1088. DMK9P7S RU https://www.ncbi.nlm.nih.gov/pubmed/28699813 DMSV42L DI DMSV42L DMSV42L DN Imidazole derivative 9 DMSV42L MI TTTJZ4M DMSV42L MN Prolylcarboxypeptidase (PRCP) DMSV42L MT DTT DMSV42L MA Inhibitor DMSV42L RN Prolylcarboxypeptidase (PrCP) inhibitors and the therapeutic uses thereof: a patent review.Expert Opin Ther Pat. 2017 Oct;27(10):1077-1088. DMSV42L RU https://www.ncbi.nlm.nih.gov/pubmed/28699813 DM7UMW2 DI DM7UMW2 DM7UMW2 DN Imidazoleisoindoles derivative 1 DM7UMW2 MI TTZJYKH DM7UMW2 MN Indoleamine 2,3-dioxygenase 1 (IDO1) DM7UMW2 MT DTT DM7UMW2 MA Inhibitor DM7UMW2 RN A patent review of IDO1 inhibitors for cancer.Expert Opin Ther Pat. 2018 Apr;28(4):317-330. DM7UMW2 RU https://www.ncbi.nlm.nih.gov/pubmed/29473428 DMRJKIQ DI DMRJKIQ DMRJKIQ DN Imidazoleisoindoles derivative 2 DMRJKIQ MI TTZJYKH DMRJKIQ MN Indoleamine 2,3-dioxygenase 1 (IDO1) DMRJKIQ MT DTT DMRJKIQ MA Inhibitor DMRJKIQ RN A patent review of IDO1 inhibitors for cancer.Expert Opin Ther Pat. 2018 Apr;28(4):317-330. DMRJKIQ RU https://www.ncbi.nlm.nih.gov/pubmed/29473428 DMECJDM DI DMECJDM DMECJDM DN Imidazolidine derivative 1 DMECJDM MI TT473XN DMECJDM MN P2X purinoceptor 7 (P2RX7) DMECJDM MT DTT DMECJDM MA Antagonist DMECJDM RN P2X7 receptor antagonists: a patent review (2010-2015).Expert Opin Ther Pat. 2017 Mar;27(3):257-267. DMECJDM RU https://www.ncbi.nlm.nih.gov/pubmed/27724045 DMUFSQ2 DI DMUFSQ2 DMUFSQ2 DN Imidazolidine-2,4-dione derivative 1 DMUFSQ2 MI TT6OEDT DMUFSQ2 MN Cannabinoid receptor 1 (CB1) DMUFSQ2 MT DTT DMUFSQ2 MA Antagonist DMUFSQ2 RN A comprehensive patents review on cannabinoid 1 receptor antagonists as antiobesity agents. Expert Opin Ther Pat. 2015 Oct;25(10):1093-116. DMUFSQ2 RU https://pubmed.ncbi.nlm.nih.gov/26161824 DMVMD2O DI DMVMD2O DMVMD2O DN Imidazolidine-2,4-dione derivative 2 DMVMD2O MI TT6OEDT DMVMD2O MN Cannabinoid receptor 1 (CB1) DMVMD2O MT DTT DMVMD2O MA Antagonist DMVMD2O RN A comprehensive patents review on cannabinoid 1 receptor antagonists as antiobesity agents. Expert Opin Ther Pat. 2015 Oct;25(10):1093-116. DMVMD2O RU https://pubmed.ncbi.nlm.nih.gov/26161824 DM847I2 DI DM847I2 DM847I2 DN Imidazolyl urea derivative 1 DM847I2 MI TTDP1UC DM847I2 MN Fatty acid amide hydrolase (FAAH) DM847I2 MT DTT DM847I2 MA Inhibitor DM847I2 RN Fatty acid amide hydrolase inhibitors: a patent review (2009-2014).Expert Opin Ther Pat. 2015;25(11):1247-66. DM847I2 RU https://www.ncbi.nlm.nih.gov/pubmed/26413912 DMEY6L8 DI DMEY6L8 DMEY6L8 DN Imidazopyridazine derivative 1 DMEY6L8 MI TT6DM01 DMEY6L8 MN Janus kinase 1 (JAK-1) DMEY6L8 MT DTT DMEY6L8 MA Inhibitor DMEY6L8 RN Inhibitors of JAK-family kinases: an update on the patent literature 2013-2015, part 1.Expert Opin Ther Pat. 2017 Feb;27(2):127-143. DMEY6L8 RU https://www.ncbi.nlm.nih.gov/pubmed/27774824 DMEY6L8 DI DMEY6L8 DMEY6L8 DN Imidazopyridazine derivative 1 DMEY6L8 MI TTT7PJU DMEY6L8 MN Janus kinase 3 (JAK-3) DMEY6L8 MT DTT DMEY6L8 MA Inhibitor DMEY6L8 RN Inhibitors of JAK-family kinases: an update on the patent literature 2013-2015, part 1.Expert Opin Ther Pat. 2017 Feb;27(2):127-143. DMEY6L8 RU https://www.ncbi.nlm.nih.gov/pubmed/27774824 DMZORKY DI DMZORKY DMZORKY DN Imidazopyridazine derivative 2 DMZORKY MI TT6DM01 DMZORKY MN Janus kinase 1 (JAK-1) DMZORKY MT DTT DMZORKY MA Inhibitor DMZORKY RN Inhibitors of JAK-family kinases: an update on the patent literature 2013-2015, part 1.Expert Opin Ther Pat. 2017 Feb;27(2):127-143. DMZORKY RU https://www.ncbi.nlm.nih.gov/pubmed/27774824 DMZORKY DI DMZORKY DMZORKY DN Imidazopyridazine derivative 2 DMZORKY MI TTT7PJU DMZORKY MN Janus kinase 3 (JAK-3) DMZORKY MT DTT DMZORKY MA Inhibitor DMZORKY RN Inhibitors of JAK-family kinases: an update on the patent literature 2013-2015, part 1.Expert Opin Ther Pat. 2017 Feb;27(2):127-143. DMZORKY RU https://www.ncbi.nlm.nih.gov/pubmed/27774824 DMXVOP3 DI DMXVOP3 DMXVOP3 DN Imidazopyridazine derivative 3 DMXVOP3 MI TTQR74A DMXVOP3 MN Proteinase activated receptor 2 (PAR2) DMXVOP3 MT DTT DMXVOP3 MA Antagonist DMXVOP3 RN Protease activated receptor 2 (PAR2) modulators: a patent review (2010-2015).Expert Opin Ther Pat. 2016;26(4):471-83. DMXVOP3 RU https://www.ncbi.nlm.nih.gov/pubmed/26936077 DMIAJMO DI DMIAJMO DMIAJMO DN Imidazopyridazine derivative 4 DMIAJMO MI TTQR74A DMIAJMO MN Proteinase activated receptor 2 (PAR2) DMIAJMO MT DTT DMIAJMO MA Antagonist DMIAJMO RN Protease activated receptor 2 (PAR2) modulators: a patent review (2010-2015).Expert Opin Ther Pat. 2016;26(4):471-83. DMIAJMO RU https://www.ncbi.nlm.nih.gov/pubmed/26936077 DM9SXYH DI DM9SXYH DM9SXYH DN Imidazopyridazine derivative 5 DM9SXYH MI TTQR74A DM9SXYH MN Proteinase activated receptor 2 (PAR2) DM9SXYH MT DTT DM9SXYH MA Antagonist DM9SXYH RN Protease activated receptor 2 (PAR2) modulators: a patent review (2010-2015).Expert Opin Ther Pat. 2016;26(4):471-83. DM9SXYH RU https://www.ncbi.nlm.nih.gov/pubmed/26936077 DM5F1LR DI DM5F1LR DM5F1LR DN Imidazopyridazine derivative 6 DM5F1LR MI TTQR74A DM5F1LR MN Proteinase activated receptor 2 (PAR2) DM5F1LR MT DTT DM5F1LR MA Antagonist DM5F1LR RN Protease activated receptor 2 (PAR2) modulators: a patent review (2010-2015).Expert Opin Ther Pat. 2016;26(4):471-83. DM5F1LR RU https://www.ncbi.nlm.nih.gov/pubmed/26936077 DM5X160 DI DM5X160 DM5X160 DN Imidazopyridazine derivative 7 DM5X160 MI TTQR74A DM5X160 MN Proteinase activated receptor 2 (PAR2) DM5X160 MT DTT DM5X160 MA Antagonist DM5X160 RN Protease activated receptor 2 (PAR2) modulators: a patent review (2010-2015).Expert Opin Ther Pat. 2016;26(4):471-83. DM5X160 RU https://www.ncbi.nlm.nih.gov/pubmed/26936077 DMF7NXJ DI DMF7NXJ DMF7NXJ DN Imidazopyridazine derivative 8 DMF7NXJ MI TTQR74A DMF7NXJ MN Proteinase activated receptor 2 (PAR2) DMF7NXJ MT DTT DMF7NXJ MA Antagonist DMF7NXJ RN Protease activated receptor 2 (PAR2) modulators: a patent review (2010-2015).Expert Opin Ther Pat. 2016;26(4):471-83. DMF7NXJ RU https://www.ncbi.nlm.nih.gov/pubmed/26936077 DMO41ZB DI DMO41ZB DMO41ZB DN Imidazopyridine acetamide analog 1 DMO41ZB MI TTPTXIN DMO41ZB MN Translocator protein (TSPO) DMO41ZB MT DTT DMO41ZB MA Ligand DMO41ZB RN Translocator protein (TSPO) ligands for the diagnosis or treatment of neurodegenerative diseases: a patent review (2010-2015; part 1).Expert Opin Ther Pat. 2016 Nov;26(11):1325-1351. DMO41ZB RU https://www.ncbi.nlm.nih.gov/pubmed/27607364 DMIKMBO DI DMIKMBO DMIKMBO DN Imidazopyridine acetamide analog 2 DMIKMBO MI TTPTXIN DMIKMBO MN Translocator protein (TSPO) DMIKMBO MT DTT DMIKMBO MA Ligand DMIKMBO RN Translocator protein (TSPO) ligands for the diagnosis or treatment of neurodegenerative diseases: a patent review (2010-2015; part 1).Expert Opin Ther Pat. 2016 Nov;26(11):1325-1351. DMIKMBO RU https://www.ncbi.nlm.nih.gov/pubmed/27607364 DMZ08LD DI DMZ08LD DMZ08LD DN Imidazopyridine acetamide analog 3 DMZ08LD MI TTPTXIN DMZ08LD MN Translocator protein (TSPO) DMZ08LD MT DTT DMZ08LD MA Ligand DMZ08LD RN Translocator protein (TSPO) ligands for the diagnosis or treatment of neurodegenerative diseases: a patent review (2010-2015; part 1).Expert Opin Ther Pat. 2016 Nov;26(11):1325-1351. DMZ08LD RU https://www.ncbi.nlm.nih.gov/pubmed/27607364 DMPHK87 DI DMPHK87 DMPHK87 DN Imidazopyridine acetamide analog 4 DMPHK87 MI TTPTXIN DMPHK87 MN Translocator protein (TSPO) DMPHK87 MT DTT DMPHK87 MA Ligand DMPHK87 RN Translocator protein (TSPO) ligands for the diagnosis or treatment of neurodegenerative diseases: a patent review (2010-2015; part 1).Expert Opin Ther Pat. 2016 Nov;26(11):1325-1351. DMPHK87 RU https://www.ncbi.nlm.nih.gov/pubmed/27607364 DMMFCRU DI DMMFCRU DMMFCRU DN Imidazopyridine acetamide analog 5 DMMFCRU MI TTPTXIN DMMFCRU MN Translocator protein (TSPO) DMMFCRU MT DTT DMMFCRU MA Ligand DMMFCRU RN Translocator protein (TSPO) ligands for the diagnosis or treatment of neurodegenerative diseases: a patent review (2010-2015; part 1).Expert Opin Ther Pat. 2016 Nov;26(11):1325-1351. DMMFCRU RU https://www.ncbi.nlm.nih.gov/pubmed/27607364 DME7M5R DI DME7M5R DME7M5R DN Imidazopyridine acetamide analog 6 DME7M5R MI TTPTXIN DME7M5R MN Translocator protein (TSPO) DME7M5R MT DTT DME7M5R MA Ligand DME7M5R RN Translocator protein (TSPO) ligands for the diagnosis or treatment of neurodegenerative diseases: a patent review (2010-2015; part 1).Expert Opin Ther Pat. 2016 Nov;26(11):1325-1351. DME7M5R RU https://www.ncbi.nlm.nih.gov/pubmed/27607364 DMQDA3I DI DMQDA3I DMQDA3I DN Imidazopyridine acetamide analog 7 DMQDA3I MI TTPTXIN DMQDA3I MN Translocator protein (TSPO) DMQDA3I MT DTT DMQDA3I MA Ligand DMQDA3I RN Translocator protein (TSPO) ligands for the diagnosis or treatment of neurodegenerative diseases: a patent review (2010-2015; part 1).Expert Opin Ther Pat. 2016 Nov;26(11):1325-1351. DMQDA3I RU https://www.ncbi.nlm.nih.gov/pubmed/27607364 DMTUS0Y DI DMTUS0Y DMTUS0Y DN Imidazopyridine and triazolopyridine compound 1 DMTUS0Y MI TTHS256 DMTUS0Y MN Metabotropic glutamate receptor 5 (mGluR5) DMTUS0Y MT DTT DMTUS0Y MA Modulator DMTUS0Y RN mGlu5 negative allosteric modulators: a patent review (2013 - 2016).Expert Opin Ther Pat. 2017 Jun;27(6):691-706. DMTUS0Y RU https://www.ncbi.nlm.nih.gov/pubmed/28067079 DMYCLAM DI DMYCLAM DMYCLAM DN Imidazopyridine and triazolopyridine compound 2 DMYCLAM MI TTHS256 DMYCLAM MN Metabotropic glutamate receptor 5 (mGluR5) DMYCLAM MT DTT DMYCLAM MA Modulator DMYCLAM RN mGlu5 negative allosteric modulators: a patent review (2013 - 2016).Expert Opin Ther Pat. 2017 Jun;27(6):691-706. DMYCLAM RU https://www.ncbi.nlm.nih.gov/pubmed/28067079 DMWU8VM DI DMWU8VM DMWU8VM DN Imidazopyridine and triazolopyridine compound 3 DMWU8VM MI TTHS256 DMWU8VM MN Metabotropic glutamate receptor 5 (mGluR5) DMWU8VM MT DTT DMWU8VM MA Modulator DMWU8VM RN mGlu5 negative allosteric modulators: a patent review (2013 - 2016).Expert Opin Ther Pat. 2017 Jun;27(6):691-706. DMWU8VM RU https://www.ncbi.nlm.nih.gov/pubmed/28067079 DMI1OWK DI DMI1OWK DMI1OWK DN Imidazopyridine and triazolopyridine compound 4 DMI1OWK MI TTHS256 DMI1OWK MN Metabotropic glutamate receptor 5 (mGluR5) DMI1OWK MT DTT DMI1OWK MA Modulator DMI1OWK RN mGlu5 negative allosteric modulators: a patent review (2013 - 2016).Expert Opin Ther Pat. 2017 Jun;27(6):691-706. DMI1OWK RU https://www.ncbi.nlm.nih.gov/pubmed/28067079 DM8EB57 DI DM8EB57 DM8EB57 DN Imidazopyridine derivative 1 DM8EB57 MI TTPTXIN DM8EB57 MN Translocator protein (TSPO) DM8EB57 MT DTT DM8EB57 MA Ligand DM8EB57 RN Translocator protein (TSPO) ligands for the diagnosis or treatment of neurodegenerative diseases: a patent review (2010-2015; part 1).Expert Opin Ther Pat. 2016 Nov;26(11):1325-1351. DM8EB57 RU https://www.ncbi.nlm.nih.gov/pubmed/27607364 DM9FRV7 DI DM9FRV7 DM9FRV7 DN Imidazopyridine derivative 2 DM9FRV7 MI TTPTXIN DM9FRV7 MN Translocator protein (TSPO) DM9FRV7 MT DTT DM9FRV7 MA Ligand DM9FRV7 RN Translocator protein (TSPO) ligands for the diagnosis or treatment of neurodegenerative diseases: a patent review (2010-2015; part 1).Expert Opin Ther Pat. 2016 Nov;26(11):1325-1351. DM9FRV7 RU https://www.ncbi.nlm.nih.gov/pubmed/27607364 DMJCSL3 DI DMJCSL3 DMJCSL3 DN Imidazopyridine derivative 3 DMJCSL3 MI TTBYWP2 DMJCSL3 MN TYK2 tyrosine kinase (TYK2) DMJCSL3 MT DTT DMJCSL3 MA Inhibitor DMJCSL3 RN Inhibitors of JAK-family kinases: an update on the patent literature 2013-2015, part 2.Expert Opin Ther Pat. 2017 Feb;27(2):145-161. DMJCSL3 RU https://www.ncbi.nlm.nih.gov/pubmed/27774822 DMP2AXV DI DMP2AXV DMP2AXV DN Imidazopyridine derivative 4 DMP2AXV MI TTT7PJU DMP2AXV MN Janus kinase 3 (JAK-3) DMP2AXV MT DTT DMP2AXV MA Inhibitor DMP2AXV RN Inhibitors of JAK-family kinases: an update on the patent literature 2013-2015, part 1.Expert Opin Ther Pat. 2017 Feb;27(2):127-143. DMP2AXV RU https://www.ncbi.nlm.nih.gov/pubmed/27774824 DMP2AXV DI DMP2AXV DMP2AXV DN Imidazopyridine derivative 4 DMP2AXV MI TTGM6VW DMP2AXV MN Tyrosine-protein kinase BTK (ATK) DMP2AXV MT DTT DMP2AXV MA Inhibitor DMP2AXV RN Inhibitors of JAK-family kinases: an update on the patent literature 2013-2015, part 1.Expert Opin Ther Pat. 2017 Feb;27(2):127-143. DMP2AXV RU https://www.ncbi.nlm.nih.gov/pubmed/27774824 DMUKBGD DI DMUKBGD DMUKBGD DN Imidazopyridine derivative 5 DMUKBGD MI TTYLQ8V DMUKBGD MN Prostaglandin E synthase (PTGES) DMUKBGD MT DTT DMUKBGD MA Inhibitor DMUKBGD RN Microsomal prostaglandin E2 synthase-1 inhibitors: a patent review.Expert Opin Ther Pat. 2017 Sep;27(9):1047-1059. DMUKBGD RU https://www.ncbi.nlm.nih.gov/pubmed/28627961 DMA0V4F DI DMA0V4F DMA0V4F DN Imidazopyridine derivative 6 DMA0V4F MI TTYLQ8V DMA0V4F MN Prostaglandin E synthase (PTGES) DMA0V4F MT DTT DMA0V4F MA Inhibitor DMA0V4F RN Microsomal prostaglandin E2 synthase-1 inhibitors: a patent review.Expert Opin Ther Pat. 2017 Sep;27(9):1047-1059. DMA0V4F RU https://www.ncbi.nlm.nih.gov/pubmed/28627961 DMI3XPJ DI DMI3XPJ DMI3XPJ DN Imidazopyridine derivative 7 DMI3XPJ MI TTYLQ8V DMI3XPJ MN Prostaglandin E synthase (PTGES) DMI3XPJ MT DTT DMI3XPJ MA Inhibitor DMI3XPJ RN Microsomal prostaglandin E2 synthase-1 inhibitors: a patent review.Expert Opin Ther Pat. 2017 Sep;27(9):1047-1059. DMI3XPJ RU https://www.ncbi.nlm.nih.gov/pubmed/28627961 DMWN17V DI DMWN17V DMWN17V DN Imidazopyrimidinone derivative 1 DMWN17V MI TTSCIM2 DMWN17V MN Extracellular lysophospholipase D (E-NPP2) DMWN17V MT DTT DMWN17V MA Inhibitor DMWN17V RN Autotaxin inhibitors: a patent review (2012-2016).Expert Opin Ther Pat. 2017 Jul;27(7):815-829. DMWN17V RU https://www.ncbi.nlm.nih.gov/pubmed/28447479 DMX34PU DI DMX34PU DMX34PU DN Imidazotriazinone derivative 1 DMX34PU MI TTJGW1Z DMX34PU MN Phosphodiesterase 2A (PDE2A) DMX34PU MT DTT DMX34PU MA Inhibitor DMX34PU RN Towards selective phosphodiesterase 2A (PDE2A) inhibitors: a patent review (2010 - present).Expert Opin Ther Pat. 2016 Aug;26(8):933-46. DMX34PU RU https://www.ncbi.nlm.nih.gov/pubmed/27321640 DMBURAZ DI DMBURAZ DMBURAZ DN IncarviatoneA DMBURAZ MI TT3WG5C DMBURAZ MN Monoamine oxidase type A (MAO-A) DMBURAZ MT DTT DMBURAZ MA Inhibitor DMBURAZ RN Novel monoamine oxidase inhibitors: a patent review (2012 - 2014).Expert Opin Ther Pat. 2015 Jan;25(1):91-110. DMBURAZ RU https://www.ncbi.nlm.nih.gov/pubmed/25399762 DMA6BCH DI DMA6BCH DMA6BCH DN Indandione derivative 1 DMA6BCH MI TTV1C0Z DMA6BCH MN Neuropeptide S receptor (NPSR) DMA6BCH MT DTT DMA6BCH MA Antagonist DMA6BCH RN Neuropeptide S receptor ligands: a patent review (2005-2016).Expert Opin Ther Pat. 2017 Mar;27(3):347-362. DMA6BCH RU https://www.ncbi.nlm.nih.gov/pubmed/27788040 DMVR04K DI DMVR04K DMVR04K DN Indandione derivative 2 DMVR04K MI TTV1C0Z DMVR04K MN Neuropeptide S receptor (NPSR) DMVR04K MT DTT DMVR04K MA Antagonist DMVR04K RN Neuropeptide S receptor ligands: a patent review (2005-2016).Expert Opin Ther Pat. 2017 Mar;27(3):347-362. DMVR04K RU https://www.ncbi.nlm.nih.gov/pubmed/27788040 DM0TURE DI DM0TURE DM0TURE DN Indandione derivative 3 DM0TURE MI TTV1C0Z DM0TURE MN Neuropeptide S receptor (NPSR) DM0TURE MT DTT DM0TURE MA Antagonist DM0TURE RN Neuropeptide S receptor ligands: a patent review (2005-2016).Expert Opin Ther Pat. 2017 Mar;27(3):347-362. DM0TURE RU https://www.ncbi.nlm.nih.gov/pubmed/27788040 DMQPTEJ DI DMQPTEJ DMQPTEJ DN Indanone and indandione derivative 1 DMQPTEJ MI TTV1C0Z DMQPTEJ MN Neuropeptide S receptor (NPSR) DMQPTEJ MT DTT DMQPTEJ MA Antagonist DMQPTEJ RN Neuropeptide S receptor ligands: a patent review (2005-2016).Expert Opin Ther Pat. 2017 Mar;27(3):347-362. DMQPTEJ RU https://www.ncbi.nlm.nih.gov/pubmed/27788040 DMKUT6S DI DMKUT6S DMKUT6S DN Indazole amide derivative 1 DMKUT6S MI TTKFVXR DMKUT6S MN Renal carcinoma antigen NY-REN-64 (IRAK-4) DMKUT6S MT DTT DMKUT6S MA Inhibitor DMKUT6S RN Inhibitors of interleukin-1 receptor-associated kinase 4 (IRAK4): a patent review (2012-2015).Expert Opin Ther Pat. 2016 Aug;26(8):917-32. DMKUT6S RU https://www.ncbi.nlm.nih.gov/pubmed/27310003 DMRPT5O DI DMRPT5O DMRPT5O DN Indazole amide derivative 2 DMRPT5O MI TTKFVXR DMRPT5O MN Renal carcinoma antigen NY-REN-64 (IRAK-4) DMRPT5O MT DTT DMRPT5O MA Inhibitor DMRPT5O RN Inhibitors of interleukin-1 receptor-associated kinase 4 (IRAK4): a patent review (2012-2015).Expert Opin Ther Pat. 2016 Aug;26(8):917-32. DMRPT5O RU https://www.ncbi.nlm.nih.gov/pubmed/27310003 DME8JTW DI DME8JTW DME8JTW DN Indazole derivative 1 DME8JTW MI TTCZOF2 DME8JTW MN Pyruvate dehydrogenase kinase 1 (PDHK1) DME8JTW MT DTT DME8JTW MA Inhibitor DME8JTW RN PDK1 disruptors and modulators: a patent review.Expert Opin Ther Pat. 2015 May;25(5):513-37. DME8JTW RU https://www.ncbi.nlm.nih.gov/pubmed/25684022 DMV7AX9 DI DMV7AX9 DMV7AX9 DN Indazole derivative 2 DMV7AX9 MI TTZJYKH DMV7AX9 MN Indoleamine 2,3-dioxygenase 1 (IDO1) DMV7AX9 MT DTT DMV7AX9 RN A patent review of IDO1 inhibitors for cancer.Expert Opin Ther Pat. 2018 Apr;28(4):317-330. DMV7AX9 RU https://www.ncbi.nlm.nih.gov/pubmed/29473428 DMVUWLK DI DMVUWLK DMVUWLK DN Indazole derivative 3 DMVUWLK MI TTZJYKH DMVUWLK MN Indoleamine 2,3-dioxygenase 1 (IDO1) DMVUWLK MT DTT DMVUWLK RN A patent review of IDO1 inhibitors for cancer.Expert Opin Ther Pat. 2018 Apr;28(4):317-330. DMVUWLK RU https://www.ncbi.nlm.nih.gov/pubmed/29473428 DMVUWLK DI DMVUWLK DMVUWLK DN Indazole derivative 3 DMVUWLK MI TTXNCBV DMVUWLK MN Tryptophan 2,3-dioxygenase (TDO) DMVUWLK MT DTT DMVUWLK RN A patent review of IDO1 inhibitors for cancer.Expert Opin Ther Pat. 2018 Apr;28(4):317-330. DMVUWLK RU https://www.ncbi.nlm.nih.gov/pubmed/29473428 DMJ2CRO DI DMJ2CRO DMJ2CRO DN Indazole derivative 4 DMJ2CRO MI TTZJYKH DMJ2CRO MN Indoleamine 2,3-dioxygenase 1 (IDO1) DMJ2CRO MT DTT DMJ2CRO RN A patent review of IDO1 inhibitors for cancer.Expert Opin Ther Pat. 2018 Apr;28(4):317-330. DMJ2CRO RU https://www.ncbi.nlm.nih.gov/pubmed/29473428 DMM1I8R DI DMM1I8R DMM1I8R DN Indazole derivative 5 DMM1I8R MI TTZJTWA DMM1I8R MN ABL T315I mutant (ABL T315I) DMM1I8R MT DTT DMM1I8R MA Inhibitor DMM1I8R RN Bcr-Abl tyrosine kinase inhibitors: a patent review.Expert Opin Ther Pat. 2015 Apr;25(4):397-412. DMM1I8R RU https://www.ncbi.nlm.nih.gov/pubmed/25656651 DMM1I8R DI DMM1I8R DMM1I8R DN Indazole derivative 5 DMM1I8R MI TTIV39N DMM1I8R MN Fusion protein Bcr-Abl T315I mutant (Bcr-Abl T315I) DMM1I8R MT DTT DMM1I8R MA Inhibitor DMM1I8R RN Bcr-Abl tyrosine kinase inhibitors: a patent review.Expert Opin Ther Pat. 2015 Apr;25(4):397-412. DMM1I8R RU https://www.ncbi.nlm.nih.gov/pubmed/25656651 DMGO1CB DI DMGO1CB DMGO1CB DN Indazole derivative 6 DMGO1CB MI TTRZQE3 DMGO1CB MN Glycogen synthase kinase-3 alpha (GSK-3A) DMGO1CB MT DTT DMGO1CB MA Inhibitor DMGO1CB RN Glycogen synthase kinase 3 (GSK-3) inhibitors: a patent update (2014-2015).Expert Opin Ther Pat. 2017 Jun;27(6):657-666. DMGO1CB RU https://www.ncbi.nlm.nih.gov/pubmed/27828716 DMHJDU6 DI DMHJDU6 DMHJDU6 DN Indazoletriazolephenyl derivative 1 DMHJDU6 MI TTXAJWN DMHJDU6 MN IL-1 receptor-associated kinase 1 (IRAK1) DMHJDU6 MT DTT DMHJDU6 MA Inhibitor DMHJDU6 RN Inhibitors of interleukin-1 receptor-associated kinase 4 (IRAK4): a patent review (2012-2015).Expert Opin Ther Pat. 2016 Aug;26(8):917-32. DMHJDU6 RU https://www.ncbi.nlm.nih.gov/pubmed/27310003 DMHJDU6 DI DMHJDU6 DMHJDU6 DN Indazoletriazolephenyl derivative 1 DMHJDU6 MI TTKFVXR DMHJDU6 MN Renal carcinoma antigen NY-REN-64 (IRAK-4) DMHJDU6 MT DTT DMHJDU6 MA Inhibitor DMHJDU6 RN Inhibitors of interleukin-1 receptor-associated kinase 4 (IRAK4): a patent review (2012-2015).Expert Opin Ther Pat. 2016 Aug;26(8):917-32. DMHJDU6 RU https://www.ncbi.nlm.nih.gov/pubmed/27310003 DMWZLK6 DI DMWZLK6 DMWZLK6 DN Indazoletriazolephenyl derivative 2 DMWZLK6 MI TTXAJWN DMWZLK6 MN IL-1 receptor-associated kinase 1 (IRAK1) DMWZLK6 MT DTT DMWZLK6 MA Inhibitor DMWZLK6 RN Inhibitors of interleukin-1 receptor-associated kinase 4 (IRAK4): a patent review (2012-2015).Expert Opin Ther Pat. 2016 Aug;26(8):917-32. DMWZLK6 RU https://www.ncbi.nlm.nih.gov/pubmed/27310003 DMWZLK6 DI DMWZLK6 DMWZLK6 DN Indazoletriazolephenyl derivative 2 DMWZLK6 MI TTKFVXR DMWZLK6 MN Renal carcinoma antigen NY-REN-64 (IRAK-4) DMWZLK6 MT DTT DMWZLK6 MA Inhibitor DMWZLK6 RN Inhibitors of interleukin-1 receptor-associated kinase 4 (IRAK4): a patent review (2012-2015).Expert Opin Ther Pat. 2016 Aug;26(8):917-32. DMWZLK6 RU https://www.ncbi.nlm.nih.gov/pubmed/27310003 DMR2GW1 DI DMR2GW1 DMR2GW1 DN Indazolyl-thiadiazolamine derivative 1 DMR2GW1 MI TTGWKQJ DMR2GW1 MN Rho-associated protein kinase 2 (ROCK2) DMR2GW1 MT DTT DMR2GW1 MA Inhibitor DMR2GW1 RN Rho kinase inhibitors: a patent review (2014 - 2016).Expert Opin Ther Pat. 2017 Apr;27(4):507-515. DMR2GW1 RU https://www.ncbi.nlm.nih.gov/pubmed/28048944 DMB8673 DI DMB8673 DMB8673 DN Indirubin derivative 1 DMB8673 MI TTLRFIH DMB8673 MN Signal transducer and activator of transcription 5 (STAT5) DMB8673 MT DTT DMB8673 MA Inhibitor DMB8673 RN A STAT inhibitor patent review: progress since 2011.Expert Opin Ther Pat. 2015;25(12):1397-421. DMB8673 RU https://www.ncbi.nlm.nih.gov/pubmed/26394986 DMLX183 DI DMLX183 DMLX183 DN Indirubin derivative 2 DMLX183 MI TTRZQE3 DMLX183 MN Glycogen synthase kinase-3 alpha (GSK-3A) DMLX183 MT DTT DMLX183 MA Inhibitor DMLX183 RN Glycogen synthase kinase 3 (GSK-3) inhibitors: a patent update (2014-2015).Expert Opin Ther Pat. 2017 Jun;27(6):657-666. DMLX183 RU https://www.ncbi.nlm.nih.gov/pubmed/27828716 DM5F8J1 DI DM5F8J1 DM5F8J1 DN Indol-5-ol derivative 1 DM5F8J1 MI TT3PJMV DM5F8J1 MN Tyrosine-protein kinase ABL1 (ABL) DM5F8J1 MT DTT DM5F8J1 MA Inhibitor DM5F8J1 RN Bcr-Abl tyrosine kinase inhibitors: a patent review.Expert Opin Ther Pat. 2015 Apr;25(4):397-412. DM5F8J1 RU https://www.ncbi.nlm.nih.gov/pubmed/25656651 DMS0169 DI DMS0169 DMS0169 DN Indole and benzimidazole derivative 1 DMS0169 MI TTN9T81 DMS0169 MN Arachidonate 15-lipoxygenase (15-LOX) DMS0169 MT DTT DMS0169 RN 15-Lipoxygenase inhibitors: a patent review.Expert Opin Ther Pat. 2016;26(1):65-88. DMS0169 RU https://www.ncbi.nlm.nih.gov/pubmed/26560362 DMLHGC9 DI DMLHGC9 DMLHGC9 DN Indole carboxamide derivative 1 DMLHGC9 MI TT473XN DMLHGC9 MN P2X purinoceptor 7 (P2RX7) DMLHGC9 MT DTT DMLHGC9 MA Antagonist DMLHGC9 RN P2X7 receptor antagonists: a patent review (2010-2015).Expert Opin Ther Pat. 2017 Mar;27(3):257-267. DMLHGC9 RU https://www.ncbi.nlm.nih.gov/pubmed/27724045 DMIGS81 DI DMIGS81 DMIGS81 DN Indole-based analog 1 DMIGS81 MI TTL53M6 DMIGS81 MN Induced myeloid leukemia cell differentiation protein Mcl-1 (MCL1) DMIGS81 MT DTT DMIGS81 MA Inhibitor DMIGS81 RN Mcl-1 inhibitors: a patent review.Expert Opin Ther Pat. 2017 Feb;27(2):163-178. DMIGS81 RU https://www.ncbi.nlm.nih.gov/pubmed/27744724 DMAM6YC DI DMAM6YC DMAM6YC DN Indole-based analog 10 DMAM6YC MI TTPTXIN DMAM6YC MN Translocator protein (TSPO) DMAM6YC MT DTT DMAM6YC MA Ligand DMAM6YC RN Translocator protein (TSPO) ligands for the diagnosis or treatment of neurodegenerative diseases: a patent review (2010 - 2015; part 2).Expert Opin Ther Pat. 2016 Nov;26(11):1353-1366. DMAM6YC RU https://www.ncbi.nlm.nih.gov/pubmed/27599163 DMVRX7S DI DMVRX7S DMVRX7S DN Indole-based analog 11 DMVRX7S MI TT7HF4W DMVRX7S MN Cyclin-dependent kinase 2 (CDK2) DMVRX7S MT DTT DMVRX7S MA Inhibitor DMVRX7S RN Cyclin-dependent kinase inhibitors for cancer therapy: a patent review (2009 - 2014).Expert Opin Ther Pat. 2015;25(9):953-70. DMVRX7S RU https://www.ncbi.nlm.nih.gov/pubmed/26161698 DMVRX7S DI DMVRX7S DMVRX7S DN Indole-based analog 11 DMVRX7S MI TTBH0VX DMVRX7S MN Histone deacetylase (HDAC) DMVRX7S MT DTT DMVRX7S MA Inhibitor DMVRX7S RN Cyclin-dependent kinase inhibitors for cancer therapy: a patent review (2009 - 2014).Expert Opin Ther Pat. 2015;25(9):953-70. DMVRX7S RU https://www.ncbi.nlm.nih.gov/pubmed/26161698 DM1CNRH DI DM1CNRH DM1CNRH DN Indole-based analog 12 DM1CNRH MI TTMBO1Z DM1CNRH MN Cyclin-dependent kinase (CDK) DM1CNRH MT DTT DM1CNRH MA Inhibitor DM1CNRH RN Cyclin-dependent kinase inhibitors for cancer therapy: a patent review (2009 - 2014).Expert Opin Ther Pat. 2015;25(9):953-70. DM1CNRH RU https://www.ncbi.nlm.nih.gov/pubmed/26161698 DMV7DFM DI DMV7DFM DMV7DFM DN Indole-based analog 13 DMV7DFM MI TTH6V3D DMV7DFM MN Cyclin-dependent kinase 1 (CDK1) DMV7DFM MT DTT DMV7DFM MA Inhibitor DMV7DFM RN Cyclin-dependent kinase inhibitors for cancer therapy: a patent review (2009 - 2014).Expert Opin Ther Pat. 2015;25(9):953-70. DMV7DFM RU https://www.ncbi.nlm.nih.gov/pubmed/26161698 DMV7DFM DI DMV7DFM DMV7DFM DN Indole-based analog 13 DMV7DFM MI TT7HF4W DMV7DFM MN Cyclin-dependent kinase 2 (CDK2) DMV7DFM MT DTT DMV7DFM MA Inhibitor DMV7DFM RN Cyclin-dependent kinase inhibitors for cancer therapy: a patent review (2009 - 2014).Expert Opin Ther Pat. 2015;25(9):953-70. DMV7DFM RU https://www.ncbi.nlm.nih.gov/pubmed/26161698 DMV7DFM DI DMV7DFM DMV7DFM DN Indole-based analog 13 DMV7DFM MI TT0PG8F DMV7DFM MN Cyclin-dependent kinase 4 (CDK4) DMV7DFM MT DTT DMV7DFM MA Inhibitor DMV7DFM RN Cyclin-dependent kinase inhibitors for cancer therapy: a patent review (2009 - 2014).Expert Opin Ther Pat. 2015;25(9):953-70. DMV7DFM RU https://www.ncbi.nlm.nih.gov/pubmed/26161698 DMV7DFM DI DMV7DFM DMV7DFM DN Indole-based analog 13 DMV7DFM MI TT1LVF2 DMV7DFM MN Cyclin-dependent kinase 9 (CDK9) DMV7DFM MT DTT DMV7DFM MA Inhibitor DMV7DFM RN Cyclin-dependent kinase inhibitors for cancer therapy: a patent review (2009 - 2014).Expert Opin Ther Pat. 2015;25(9):953-70. DMV7DFM RU https://www.ncbi.nlm.nih.gov/pubmed/26161698 DMQURWZ DI DMQURWZ DMQURWZ DN Indole-based analog 14 DMQURWZ MI TTUM2ZR DMQURWZ MN Ribosomal protein S6 kinase alpha-3 (RSK3) DMQURWZ MT DTT DMQURWZ MA Inhibitor DMQURWZ RN Ribosomal S6 kinase (RSK) modulators: a patent review.Expert Opin Ther Pat. 2016 Sep;26(9):1061-78. DMQURWZ RU https://www.ncbi.nlm.nih.gov/pubmed/27410995 DM0NEVC DI DM0NEVC DM0NEVC DN Indole-based analog 2 DM0NEVC MI TTJGNVC DM0NEVC MN Apoptosis regulator Bcl-2 (BCL-2) DM0NEVC MT DTT DM0NEVC MA Inhibitor DM0NEVC RN Mcl-1 inhibitors: a patent review.Expert Opin Ther Pat. 2017 Feb;27(2):163-178. DM0NEVC RU https://www.ncbi.nlm.nih.gov/pubmed/27744724 DM0NEVC DI DM0NEVC DM0NEVC DN Indole-based analog 2 DM0NEVC MI TTU1E82 DM0NEVC MN Apoptosis regulator Bcl-xL (BCL-xL) DM0NEVC MT DTT DM0NEVC MA Inhibitor DM0NEVC RN Mcl-1 inhibitors: a patent review.Expert Opin Ther Pat. 2017 Feb;27(2):163-178. DM0NEVC RU https://www.ncbi.nlm.nih.gov/pubmed/27744724 DM0NEVC DI DM0NEVC DM0NEVC DN Indole-based analog 2 DM0NEVC MI TTL53M6 DM0NEVC MN Induced myeloid leukemia cell differentiation protein Mcl-1 (MCL1) DM0NEVC MT DTT DM0NEVC MA Inhibitor DM0NEVC RN Mcl-1 inhibitors: a patent review.Expert Opin Ther Pat. 2017 Feb;27(2):163-178. DM0NEVC RU https://www.ncbi.nlm.nih.gov/pubmed/27744724 DMTEYQJ DI DMTEYQJ DMTEYQJ DN Indole-based analog 3 DMTEYQJ MI TTJGNVC DMTEYQJ MN Apoptosis regulator Bcl-2 (BCL-2) DMTEYQJ MT DTT DMTEYQJ MA Inhibitor DMTEYQJ RN Mcl-1 inhibitors: a patent review.Expert Opin Ther Pat. 2017 Feb;27(2):163-178. DMTEYQJ RU https://www.ncbi.nlm.nih.gov/pubmed/27744724 DMTEYQJ DI DMTEYQJ DMTEYQJ DN Indole-based analog 3 DMTEYQJ MI TTU1E82 DMTEYQJ MN Apoptosis regulator Bcl-xL (BCL-xL) DMTEYQJ MT DTT DMTEYQJ MA Inhibitor DMTEYQJ RN Mcl-1 inhibitors: a patent review.Expert Opin Ther Pat. 2017 Feb;27(2):163-178. DMTEYQJ RU https://www.ncbi.nlm.nih.gov/pubmed/27744724 DMTEYQJ DI DMTEYQJ DMTEYQJ DN Indole-based analog 3 DMTEYQJ MI TTL53M6 DMTEYQJ MN Induced myeloid leukemia cell differentiation protein Mcl-1 (MCL1) DMTEYQJ MT DTT DMTEYQJ MA Inhibitor DMTEYQJ RN Mcl-1 inhibitors: a patent review.Expert Opin Ther Pat. 2017 Feb;27(2):163-178. DMTEYQJ RU https://www.ncbi.nlm.nih.gov/pubmed/27744724 DM5JUR2 DI DM5JUR2 DM5JUR2 DN Indole-based analog 5 DM5JUR2 MI TTPTXIN DM5JUR2 MN Translocator protein (TSPO) DM5JUR2 MT DTT DM5JUR2 MA Ligand DM5JUR2 RN Translocator protein (TSPO) ligands for the diagnosis or treatment of neurodegenerative diseases: a patent review (2010 - 2015; part 2).Expert Opin Ther Pat. 2016 Nov;26(11):1353-1366. DM5JUR2 RU https://www.ncbi.nlm.nih.gov/pubmed/27599163 DMFI2H6 DI DMFI2H6 DMFI2H6 DN Indole-based analog 9 DMFI2H6 MI TTPTXIN DMFI2H6 MN Translocator protein (TSPO) DMFI2H6 MT DTT DMFI2H6 MA Ligand DMFI2H6 RN Translocator protein (TSPO) ligands for the diagnosis or treatment of neurodegenerative diseases: a patent review (2010 - 2015; part 2).Expert Opin Ther Pat. 2016 Nov;26(11):1353-1366. DMFI2H6 RU https://www.ncbi.nlm.nih.gov/pubmed/27599163 DMJ41UI DI DMJ41UI DMJ41UI DN Indoline derivative 1 DMJ41UI MI TT1RS9F DMJ41UI MN Acetylcholinesterase (AChE) DMJ41UI MT DTT DMJ41UI MA Inhibitor DMJ41UI RN A patent review of butyrylcholinesterase inhibitors and reactivators 2010-2017.Expert Opin Ther Pat. 2018 Jun;28(6):455-465. DMJ41UI RU https://www.ncbi.nlm.nih.gov/pubmed/29757691 DMJ41UI DI DMJ41UI DMJ41UI DN Indoline derivative 1 DMJ41UI MI TTEB0GD DMJ41UI MN Cholinesterase (BCHE) DMJ41UI MT DTT DMJ41UI MA Inhibitor DMJ41UI RN A patent review of butyrylcholinesterase inhibitors and reactivators 2010-2017.Expert Opin Ther Pat. 2018 Jun;28(6):455-465. DMJ41UI RU https://www.ncbi.nlm.nih.gov/pubmed/29757691 DMTPGRO DI DMTPGRO DMTPGRO DN Indoline derivative 10 DMTPGRO MI TT5OU0D DMTPGRO MN PRKR-like endoplasmic reticulum kinase (PERK) DMTPGRO MT DTT DMTPGRO MA Inhibitor DMTPGRO RN Protein kinase R(PKR)-like endoplasmic reticulum kinase (PERK) inhibitors: a patent review (2010-2015).Expert Opin Ther Pat. 2017 Jan;27(1):37-48. DMTPGRO RU https://www.ncbi.nlm.nih.gov/pubmed/27646439 DM6JR3X DI DM6JR3X DM6JR3X DN Indoline derivative 11 DM6JR3X MI TT5OU0D DM6JR3X MN PRKR-like endoplasmic reticulum kinase (PERK) DM6JR3X MT DTT DM6JR3X MA Inhibitor DM6JR3X RN Protein kinase R(PKR)-like endoplasmic reticulum kinase (PERK) inhibitors: a patent review (2010-2015).Expert Opin Ther Pat. 2017 Jan;27(1):37-48. DM6JR3X RU https://www.ncbi.nlm.nih.gov/pubmed/27646439 DMJURBM DI DMJURBM DMJURBM DN Indoline derivative 12 DMJURBM MI TTOHSBA DMJURBM MN Vascular endothelial growth factor A (VEGFA) DMJURBM MT DTT DMJURBM MA Inhibitor DMJURBM RN VEGFR-2 inhibitors and the therapeutic applications thereof: a patent review (2012-2016).Expert Opin Ther Pat. 2017 Sep;27(9):987-1004. DMJURBM RU https://www.ncbi.nlm.nih.gov/pubmed/28621580 DM982GD DI DM982GD DM982GD DN Indoline derivative 13 DM982GD MI TTOHSBA DM982GD MN Vascular endothelial growth factor A (VEGFA) DM982GD MT DTT DM982GD MA Inhibitor DM982GD RN VEGFR-2 inhibitors and the therapeutic applications thereof: a patent review (2012-2016).Expert Opin Ther Pat. 2017 Sep;27(9):987-1004. DM982GD RU https://www.ncbi.nlm.nih.gov/pubmed/28621580 DM8DHRN DI DM8DHRN DM8DHRN DN Indoline derivative 14 DM8DHRN MI TTOHSBA DM8DHRN MN Vascular endothelial growth factor A (VEGFA) DM8DHRN MT DTT DM8DHRN MA Inhibitor DM8DHRN RN VEGFR-2 inhibitors and the therapeutic applications thereof: a patent review (2012-2016).Expert Opin Ther Pat. 2017 Sep;27(9):987-1004. DM8DHRN RU https://www.ncbi.nlm.nih.gov/pubmed/28621580 DMRFEH4 DI DMRFEH4 DMRFEH4 DN Indoline derivative 15 DMRFEH4 MI TTOHSBA DMRFEH4 MN Vascular endothelial growth factor A (VEGFA) DMRFEH4 MT DTT DMRFEH4 MA Inhibitor DMRFEH4 RN VEGFR-2 inhibitors and the therapeutic applications thereof: a patent review (2012-2016).Expert Opin Ther Pat. 2017 Sep;27(9):987-1004. DMRFEH4 RU https://www.ncbi.nlm.nih.gov/pubmed/28621580 DM9AGBT DI DM9AGBT DM9AGBT DN Indoline derivative 16 DM9AGBT MI TTOHSBA DM9AGBT MN Vascular endothelial growth factor A (VEGFA) DM9AGBT MT DTT DM9AGBT MA Inhibitor DM9AGBT RN VEGFR-2 inhibitors and the therapeutic applications thereof: a patent review (2012-2016).Expert Opin Ther Pat. 2017 Sep;27(9):987-1004. DM9AGBT RU https://www.ncbi.nlm.nih.gov/pubmed/28621580 DMXSFJ8 DI DMXSFJ8 DMXSFJ8 DN Indoline derivative 17 DMXSFJ8 MI TTOHSBA DMXSFJ8 MN Vascular endothelial growth factor A (VEGFA) DMXSFJ8 MT DTT DMXSFJ8 MA Inhibitor DMXSFJ8 RN VEGFR-2 inhibitors and the therapeutic applications thereof: a patent review (2012-2016).Expert Opin Ther Pat. 2017 Sep;27(9):987-1004. DMXSFJ8 RU https://www.ncbi.nlm.nih.gov/pubmed/28621580 DMX640D DI DMX640D DMX640D DN Indoline derivative 18 DMX640D MI TTOHSBA DMX640D MN Vascular endothelial growth factor A (VEGFA) DMX640D MT DTT DMX640D MA Inhibitor DMX640D RN VEGFR-2 inhibitors and the therapeutic applications thereof: a patent review (2012-2016).Expert Opin Ther Pat. 2017 Sep;27(9):987-1004. DMX640D RU https://www.ncbi.nlm.nih.gov/pubmed/28621580 DMOHITL DI DMOHITL DMOHITL DN Indoline derivative 19 DMOHITL MI TTOHSBA DMOHITL MN Vascular endothelial growth factor A (VEGFA) DMOHITL MT DTT DMOHITL MA Inhibitor DMOHITL RN VEGFR-2 inhibitors and the therapeutic applications thereof: a patent review (2012-2016).Expert Opin Ther Pat. 2017 Sep;27(9):987-1004. DMOHITL RU https://www.ncbi.nlm.nih.gov/pubmed/28621580 DMASXR5 DI DMASXR5 DMASXR5 DN Indoline derivative 2 DMASXR5 MI TT5OU0D DMASXR5 MN PRKR-like endoplasmic reticulum kinase (PERK) DMASXR5 MT DTT DMASXR5 MA Inhibitor DMASXR5 RN Protein kinase R(PKR)-like endoplasmic reticulum kinase (PERK) inhibitors: a patent review (2010-2015).Expert Opin Ther Pat. 2017 Jan;27(1):37-48. DMASXR5 RU https://www.ncbi.nlm.nih.gov/pubmed/27646439 DM4JNLQ DI DM4JNLQ DM4JNLQ DN Indoline derivative 20 DM4JNLQ MI TTOHSBA DM4JNLQ MN Vascular endothelial growth factor A (VEGFA) DM4JNLQ MT DTT DM4JNLQ MA Inhibitor DM4JNLQ RN VEGFR-2 inhibitors and the therapeutic applications thereof: a patent review (2012-2016).Expert Opin Ther Pat. 2017 Sep;27(9):987-1004. DM4JNLQ RU https://www.ncbi.nlm.nih.gov/pubmed/28621580 DM3YPX1 DI DM3YPX1 DM3YPX1 DN Indoline derivative 21 DM3YPX1 MI TTOHSBA DM3YPX1 MN Vascular endothelial growth factor A (VEGFA) DM3YPX1 MT DTT DM3YPX1 MA Inhibitor DM3YPX1 RN VEGFR-2 inhibitors and the therapeutic applications thereof: a patent review (2012-2016).Expert Opin Ther Pat. 2017 Sep;27(9):987-1004. DM3YPX1 RU https://www.ncbi.nlm.nih.gov/pubmed/28621580 DM20YBJ DI DM20YBJ DM20YBJ DN Indoline derivative 3 DM20YBJ MI TT5OU0D DM20YBJ MN PRKR-like endoplasmic reticulum kinase (PERK) DM20YBJ MT DTT DM20YBJ MA Inhibitor DM20YBJ RN Protein kinase R(PKR)-like endoplasmic reticulum kinase (PERK) inhibitors: a patent review (2010-2015).Expert Opin Ther Pat. 2017 Jan;27(1):37-48. DM20YBJ RU https://www.ncbi.nlm.nih.gov/pubmed/27646439 DMU5KWC DI DMU5KWC DMU5KWC DN Indoline derivative 6 DMU5KWC MI TT5OU0D DMU5KWC MN PRKR-like endoplasmic reticulum kinase (PERK) DMU5KWC MT DTT DMU5KWC MA Inhibitor DMU5KWC RN Protein kinase R(PKR)-like endoplasmic reticulum kinase (PERK) inhibitors: a patent review (2010-2015).Expert Opin Ther Pat. 2017 Jan;27(1):37-48. DMU5KWC RU https://www.ncbi.nlm.nih.gov/pubmed/27646439 DMXS46Y DI DMXS46Y DMXS46Y DN Indoline derivative 7 DMXS46Y MI TT5OU0D DMXS46Y MN PRKR-like endoplasmic reticulum kinase (PERK) DMXS46Y MT DTT DMXS46Y MA Inhibitor DMXS46Y RN Protein kinase R(PKR)-like endoplasmic reticulum kinase (PERK) inhibitors: a patent review (2010-2015).Expert Opin Ther Pat. 2017 Jan;27(1):37-48. DMXS46Y RU https://www.ncbi.nlm.nih.gov/pubmed/27646439 DMS8KMB DI DMS8KMB DMS8KMB DN Indoline derivative 8 DMS8KMB MI TT5OU0D DMS8KMB MN PRKR-like endoplasmic reticulum kinase (PERK) DMS8KMB MT DTT DMS8KMB MA Inhibitor DMS8KMB RN Protein kinase R(PKR)-like endoplasmic reticulum kinase (PERK) inhibitors: a patent review (2010-2015).Expert Opin Ther Pat. 2017 Jan;27(1):37-48. DMS8KMB RU https://www.ncbi.nlm.nih.gov/pubmed/27646439 DMCORT3 DI DMCORT3 DMCORT3 DN Indoline derivative 9 DMCORT3 MI TT5OU0D DMCORT3 MN PRKR-like endoplasmic reticulum kinase (PERK) DMCORT3 MT DTT DMCORT3 MA Inhibitor DMCORT3 RN Protein kinase R(PKR)-like endoplasmic reticulum kinase (PERK) inhibitors: a patent review (2010-2015).Expert Opin Ther Pat. 2017 Jan;27(1):37-48. DMCORT3 RU https://www.ncbi.nlm.nih.gov/pubmed/27646439 DMTC129 DI DMTC129 DMTC129 DN Indolinone derivative 1 DMTC129 MI TTCZOF2 DMTC129 MN Pyruvate dehydrogenase kinase 1 (PDHK1) DMTC129 MT DTT DMTC129 MA Inhibitor DMTC129 RN PDK1 disruptors and modulators: a patent review.Expert Opin Ther Pat. 2015 May;25(5):513-37. DMTC129 RU https://www.ncbi.nlm.nih.gov/pubmed/25684022 DM4GZBI DI DM4GZBI DM4GZBI DN Indolizine derivative 1 DM4GZBI MI TTN9T81 DM4GZBI MN Arachidonate 15-lipoxygenase (15-LOX) DM4GZBI MT DTT DM4GZBI MA Inhibitor DM4GZBI RN Inhibitors of phospholipase A2 and their therapeutic potential: an update on patents (2012-2016).Expert Opin Ther Pat. 2017 Feb;27(2):217-225. DM4GZBI RU https://www.ncbi.nlm.nih.gov/pubmed/27718763 DM4GZBI DI DM4GZBI DM4GZBI DN Indolizine derivative 1 DM4GZBI MI TTDNFMT DM4GZBI MN Platelet-activating factor acetylhydrolase (PLA2G7) DM4GZBI MT DTT DM4GZBI MA Inhibitor DM4GZBI RN Inhibitors of phospholipase A2 and their therapeutic potential: an update on patents (2012-2016).Expert Opin Ther Pat. 2017 Feb;27(2):217-225. DM4GZBI RU https://www.ncbi.nlm.nih.gov/pubmed/27718763 DM3E5V6 DI DM3E5V6 DM3E5V6 DN Indomethacin analog 1 DM3E5V6 MI TT5ZWB6 DM3E5V6 MN Dihydrodiol dehydrogenase type I (AKR1C3) DM3E5V6 MT DTT DM3E5V6 MA Inhibitor; Antagonist; Blocker DM3E5V6 RN Aldo-Keto Reductase (AKR) 1C3 inhibitors: a patent review.Expert Opin Ther Pat. 2017 Dec;27(12):1329-1340. DM3E5V6 RU https://www.ncbi.nlm.nih.gov/pubmed/28895472 DMKFPJ7 DI DMKFPJ7 DMKFPJ7 DN Indomethacin analog 2 DMKFPJ7 MI TT5ZWB6 DMKFPJ7 MN Dihydrodiol dehydrogenase type I (AKR1C3) DMKFPJ7 MT DTT DMKFPJ7 MA Inhibitor; Antagonist; Blocker DMKFPJ7 RN Aldo-Keto Reductase (AKR) 1C3 inhibitors: a patent review.Expert Opin Ther Pat. 2017 Dec;27(12):1329-1340. DMKFPJ7 RU https://www.ncbi.nlm.nih.gov/pubmed/28895472 DM53JXE DI DM53JXE DM53JXE DN Indomethacin analog 3 DM53JXE MI TT5ZWB6 DM53JXE MN Dihydrodiol dehydrogenase type I (AKR1C3) DM53JXE MT DTT DM53JXE MA Inhibitor; Antagonist; Blocker DM53JXE RN Aldo-Keto Reductase (AKR) 1C3 inhibitors: a patent review.Expert Opin Ther Pat. 2017 Dec;27(12):1329-1340. DM53JXE RU https://www.ncbi.nlm.nih.gov/pubmed/28895472 DMI3YO7 DI DMI3YO7 DMI3YO7 DN Iodophenyl-N-methyl-N-fluoroalkyl-3-isoquinoline carboxamide derivative 1 DMI3YO7 MI TTPTXIN DMI3YO7 MN Translocator protein (TSPO) DMI3YO7 MT DTT DMI3YO7 MA Ligand DMI3YO7 RN Translocator protein (TSPO) ligands for the diagnosis or treatment of neurodegenerative diseases: a patent review (2010-2015; part 1).Expert Opin Ther Pat. 2016 Nov;26(11):1325-1351. DMI3YO7 RU https://www.ncbi.nlm.nih.gov/pubmed/27607364 DM8LNXQ DI DM8LNXQ DM8LNXQ DN Iodophenyl-N-methyl-N-fluoroalkyl-3-isoquinoline carboxamide derivative 2 DM8LNXQ MI TTPTXIN DM8LNXQ MN Translocator protein (TSPO) DM8LNXQ MT DTT DM8LNXQ MA Ligand DM8LNXQ RN Translocator protein (TSPO) ligands for the diagnosis or treatment of neurodegenerative diseases: a patent review (2010-2015; part 1).Expert Opin Ther Pat. 2016 Nov;26(11):1325-1351. DM8LNXQ RU https://www.ncbi.nlm.nih.gov/pubmed/27607364 DM39H1F DI DM39H1F DM39H1F DN Iodophenyl-N-methyl-N-fluoroalkyl-3-isoquinoline carboxamide derivative 3 DM39H1F MI TTPTXIN DM39H1F MN Translocator protein (TSPO) DM39H1F MT DTT DM39H1F MA Ligand DM39H1F RN Translocator protein (TSPO) ligands for the diagnosis or treatment of neurodegenerative diseases: a patent review (2010-2015; part 1).Expert Opin Ther Pat. 2016 Nov;26(11):1325-1351. DM39H1F RU https://www.ncbi.nlm.nih.gov/pubmed/27607364 DMDBK6O DI DMDBK6O DMDBK6O DN Isochroman-4-ketone derivative 1 DMDBK6O MI TT1RS9F DMDBK6O MN Acetylcholinesterase (AChE) DMDBK6O MT DTT DMDBK6O MA Inhibitor DMDBK6O RN A patent review of butyrylcholinesterase inhibitors and reactivators 2010-2017.Expert Opin Ther Pat. 2018 Jun;28(6):455-465. DMDBK6O RU https://www.ncbi.nlm.nih.gov/pubmed/29757691 DMDBK6O DI DMDBK6O DMDBK6O DN Isochroman-4-ketone derivative 1 DMDBK6O MI TTEB0GD DMDBK6O MN Cholinesterase (BCHE) DMDBK6O MT DTT DMDBK6O MA Inhibitor DMDBK6O RN A patent review of butyrylcholinesterase inhibitors and reactivators 2010-2017.Expert Opin Ther Pat. 2018 Jun;28(6):455-465. DMDBK6O RU https://www.ncbi.nlm.nih.gov/pubmed/29757691 DMMCWH9 DI DMMCWH9 DMMCWH9 DN Isoflavone derivative 1 DMMCWH9 MI TT8J1S3 DMMCWH9 MN Smoothened homolog (SMO) DMMCWH9 MT DTT DMMCWH9 MA Inhibitor DMMCWH9 RN Evaluation of WO2014207069 A1: Multitarget Hedgehog pathway inhibitors and uses thereof.Expert Opin Ther Pat. 2016;26(4):529-35. DMMCWH9 RU https://www.ncbi.nlm.nih.gov/pubmed/26666870 DMMCWH9 DI DMMCWH9 DMMCWH9 DN Isoflavone derivative 1 DMMCWH9 MI TTJOMH6 DMMCWH9 MN Zinc finger protein GLI1 (Gli1) DMMCWH9 MT DTT DMMCWH9 MA Inhibitor DMMCWH9 RN Evaluation of WO2014207069 A1: Multitarget Hedgehog pathway inhibitors and uses thereof.Expert Opin Ther Pat. 2016;26(4):529-35. DMMCWH9 RU https://www.ncbi.nlm.nih.gov/pubmed/26666870 DMTWAH3 DI DMTWAH3 DMTWAH3 DN Isoflavone derivative 2 DMTWAH3 MI TT8J1S3 DMTWAH3 MN Smoothened homolog (SMO) DMTWAH3 MT DTT DMTWAH3 MA Inhibitor DMTWAH3 RN Evaluation of WO2014207069 A1: Multitarget Hedgehog pathway inhibitors and uses thereof.Expert Opin Ther Pat. 2016;26(4):529-35. DMTWAH3 RU https://www.ncbi.nlm.nih.gov/pubmed/26666870 DMTWAH3 DI DMTWAH3 DMTWAH3 DN Isoflavone derivative 2 DMTWAH3 MI TTJOMH6 DMTWAH3 MN Zinc finger protein GLI1 (Gli1) DMTWAH3 MT DTT DMTWAH3 MA Inhibitor DMTWAH3 RN Evaluation of WO2014207069 A1: Multitarget Hedgehog pathway inhibitors and uses thereof.Expert Opin Ther Pat. 2016;26(4):529-35. DMTWAH3 RU https://www.ncbi.nlm.nih.gov/pubmed/26666870 DMYFKR2 DI DMYFKR2 DMYFKR2 DN Isoflavone derivative 3 DMYFKR2 MI TT8J1S3 DMYFKR2 MN Smoothened homolog (SMO) DMYFKR2 MT DTT DMYFKR2 MA Inhibitor DMYFKR2 RN Evaluation of WO2014207069 A1: Multitarget Hedgehog pathway inhibitors and uses thereof.Expert Opin Ther Pat. 2016;26(4):529-35. DMYFKR2 RU https://www.ncbi.nlm.nih.gov/pubmed/26666870 DMYFKR2 DI DMYFKR2 DMYFKR2 DN Isoflavone derivative 3 DMYFKR2 MI TTJOMH6 DMYFKR2 MN Zinc finger protein GLI1 (Gli1) DMYFKR2 MT DTT DMYFKR2 MA Inhibitor DMYFKR2 RN Evaluation of WO2014207069 A1: Multitarget Hedgehog pathway inhibitors and uses thereof.Expert Opin Ther Pat. 2016;26(4):529-35. DMYFKR2 RU https://www.ncbi.nlm.nih.gov/pubmed/26666870 DMYRU7I DI DMYRU7I DMYRU7I DN Isoflavone derivative 4 DMYRU7I MI TT8J1S3 DMYRU7I MN Smoothened homolog (SMO) DMYRU7I MT DTT DMYRU7I MA Inhibitor DMYRU7I RN Evaluation of WO2014207069 A1: Multitarget Hedgehog pathway inhibitors and uses thereof.Expert Opin Ther Pat. 2016;26(4):529-35. DMYRU7I RU https://www.ncbi.nlm.nih.gov/pubmed/26666870 DMYRU7I DI DMYRU7I DMYRU7I DN Isoflavone derivative 4 DMYRU7I MI TTJOMH6 DMYRU7I MN Zinc finger protein GLI1 (Gli1) DMYRU7I MT DTT DMYRU7I MA Inhibitor DMYRU7I RN Evaluation of WO2014207069 A1: Multitarget Hedgehog pathway inhibitors and uses thereof.Expert Opin Ther Pat. 2016;26(4):529-35. DMYRU7I RU https://www.ncbi.nlm.nih.gov/pubmed/26666870 DM2GL47 DI DM2GL47 DM2GL47 DN Isoflavone derivative 5 DM2GL47 MI TT8J1S3 DM2GL47 MN Smoothened homolog (SMO) DM2GL47 MT DTT DM2GL47 MA Inhibitor DM2GL47 RN Evaluation of WO2014207069 A1: Multitarget Hedgehog pathway inhibitors and uses thereof.Expert Opin Ther Pat. 2016;26(4):529-35. DM2GL47 RU https://www.ncbi.nlm.nih.gov/pubmed/26666870 DM2GL47 DI DM2GL47 DM2GL47 DN Isoflavone derivative 5 DM2GL47 MI TTJOMH6 DM2GL47 MN Zinc finger protein GLI1 (Gli1) DM2GL47 MT DTT DM2GL47 MA Inhibitor DM2GL47 RN Evaluation of WO2014207069 A1: Multitarget Hedgehog pathway inhibitors and uses thereof.Expert Opin Ther Pat. 2016;26(4):529-35. DM2GL47 RU https://www.ncbi.nlm.nih.gov/pubmed/26666870 DM2ZYVL DI DM2ZYVL DM2ZYVL DN Isoflavone derivative 6 DM2ZYVL MI TT8J1S3 DM2ZYVL MN Smoothened homolog (SMO) DM2ZYVL MT DTT DM2ZYVL MA Inhibitor DM2ZYVL RN Evaluation of WO2014207069 A1: Multitarget Hedgehog pathway inhibitors and uses thereof.Expert Opin Ther Pat. 2016;26(4):529-35. DM2ZYVL RU https://www.ncbi.nlm.nih.gov/pubmed/26666870 DM2ZYVL DI DM2ZYVL DM2ZYVL DN Isoflavone derivative 6 DM2ZYVL MI TTJOMH6 DM2ZYVL MN Zinc finger protein GLI1 (Gli1) DM2ZYVL MT DTT DM2ZYVL MA Inhibitor DM2ZYVL RN Evaluation of WO2014207069 A1: Multitarget Hedgehog pathway inhibitors and uses thereof.Expert Opin Ther Pat. 2016;26(4):529-35. DM2ZYVL RU https://www.ncbi.nlm.nih.gov/pubmed/26666870 DMNCHBL DI DMNCHBL DMNCHBL DN Isoflavone derivative 7 DMNCHBL MI TT8J1S3 DMNCHBL MN Smoothened homolog (SMO) DMNCHBL MT DTT DMNCHBL MA Inhibitor DMNCHBL RN Evaluation of WO2014207069 A1: Multitarget Hedgehog pathway inhibitors and uses thereof.Expert Opin Ther Pat. 2016;26(4):529-35. DMNCHBL RU https://www.ncbi.nlm.nih.gov/pubmed/26666870 DMNCHBL DI DMNCHBL DMNCHBL DN Isoflavone derivative 7 DMNCHBL MI TTJOMH6 DMNCHBL MN Zinc finger protein GLI1 (Gli1) DMNCHBL MT DTT DMNCHBL MA Inhibitor DMNCHBL RN Evaluation of WO2014207069 A1: Multitarget Hedgehog pathway inhibitors and uses thereof.Expert Opin Ther Pat. 2016;26(4):529-35. DMNCHBL RU https://www.ncbi.nlm.nih.gov/pubmed/26666870 DMN0XJQ DI DMN0XJQ DMN0XJQ DN Isoflavone derivative 8 DMN0XJQ MI TT8J1S3 DMN0XJQ MN Smoothened homolog (SMO) DMN0XJQ MT DTT DMN0XJQ MA Inhibitor DMN0XJQ RN Evaluation of WO2014207069 A1: Multitarget Hedgehog pathway inhibitors and uses thereof.Expert Opin Ther Pat. 2016;26(4):529-35. DMN0XJQ RU https://www.ncbi.nlm.nih.gov/pubmed/26666870 DMN0XJQ DI DMN0XJQ DMN0XJQ DN Isoflavone derivative 8 DMN0XJQ MI TTJOMH6 DMN0XJQ MN Zinc finger protein GLI1 (Gli1) DMN0XJQ MT DTT DMN0XJQ MA Inhibitor DMN0XJQ RN Evaluation of WO2014207069 A1: Multitarget Hedgehog pathway inhibitors and uses thereof.Expert Opin Ther Pat. 2016;26(4):529-35. DMN0XJQ RU https://www.ncbi.nlm.nih.gov/pubmed/26666870 DMA78MD DI DMA78MD DMA78MD DN Isoflavone derivative 9 DMA78MD MI TT8J1S3 DMA78MD MN Smoothened homolog (SMO) DMA78MD MT DTT DMA78MD MA Inhibitor DMA78MD RN Evaluation of WO2014207069 A1: Multitarget Hedgehog pathway inhibitors and uses thereof.Expert Opin Ther Pat. 2016;26(4):529-35. DMA78MD RU https://www.ncbi.nlm.nih.gov/pubmed/26666870 DMA78MD DI DMA78MD DMA78MD DN Isoflavone derivative 9 DMA78MD MI TTJOMH6 DMA78MD MN Zinc finger protein GLI1 (Gli1) DMA78MD MT DTT DMA78MD MA Inhibitor DMA78MD RN Evaluation of WO2014207069 A1: Multitarget Hedgehog pathway inhibitors and uses thereof.Expert Opin Ther Pat. 2016;26(4):529-35. DMA78MD RU https://www.ncbi.nlm.nih.gov/pubmed/26666870 DMWTU8X DI DMWTU8X DMWTU8X DN Isoindole 1,3-dione analog 1 DMWTU8X MI TT473XN DMWTU8X MN P2X purinoceptor 7 (P2RX7) DMWTU8X MT DTT DMWTU8X MA Antagonist DMWTU8X RN P2X7 receptor antagonists: a patent review (2010-2015).Expert Opin Ther Pat. 2017 Mar;27(3):257-267. DMWTU8X RU https://www.ncbi.nlm.nih.gov/pubmed/27724045 DMD19QC DI DMD19QC DMD19QC DN Isoindoline derivative 1 DMD19QC MI TT5TPI6 DMD19QC MN Opioid receptor sigma 1 (OPRS1) DMD19QC MT DTT DMD19QC MA Ligand DMD19QC RN The sigma-2 (-2) receptor: a review of recent patent applications: 2013-2018.Expert Opin Ther Pat. 2018 Sep;28(9):655-663. DMD19QC RU https://www.ncbi.nlm.nih.gov/pubmed/30185082 DMD19QC DI DMD19QC DMD19QC DN Isoindoline derivative 1 DMD19QC MI TT9NXW4 DMD19QC MN Sigma intracellular receptor 2 (TMEM97) DMD19QC MT DTT DMD19QC MA Ligand DMD19QC RN The sigma-2 (-2) receptor: a review of recent patent applications: 2013-2018.Expert Opin Ther Pat. 2018 Sep;28(9):655-663. DMD19QC RU https://www.ncbi.nlm.nih.gov/pubmed/30185082 DMD19QC DI DMD19QC DMD19QC DN Isoindoline derivative 1 DMD19QC MI TTQ6VDM DMD19QC MN Voltage-gated potassium channel Kv11.1 (KCNH2) DMD19QC MT DTT DMD19QC MA Ligand DMD19QC RN The sigma-2 (-2) receptor: a review of recent patent applications: 2013-2018.Expert Opin Ther Pat. 2018 Sep;28(9):655-663. DMD19QC RU https://www.ncbi.nlm.nih.gov/pubmed/30185082 DMTE0S3 DI DMTE0S3 DMTE0S3 DN Isoindoline derivative 2 DMTE0S3 MI TT5TPI6 DMTE0S3 MN Opioid receptor sigma 1 (OPRS1) DMTE0S3 MT DTT DMTE0S3 MA Ligand DMTE0S3 RN The sigma-2 (-2) receptor: a review of recent patent applications: 2013-2018.Expert Opin Ther Pat. 2018 Sep;28(9):655-663. DMTE0S3 RU https://www.ncbi.nlm.nih.gov/pubmed/30185082 DMTE0S3 DI DMTE0S3 DMTE0S3 DN Isoindoline derivative 2 DMTE0S3 MI TT9NXW4 DMTE0S3 MN Sigma intracellular receptor 2 (TMEM97) DMTE0S3 MT DTT DMTE0S3 MA Ligand DMTE0S3 RN The sigma-2 (-2) receptor: a review of recent patent applications: 2013-2018.Expert Opin Ther Pat. 2018 Sep;28(9):655-663. DMTE0S3 RU https://www.ncbi.nlm.nih.gov/pubmed/30185082 DMTE0S3 DI DMTE0S3 DMTE0S3 DN Isoindoline derivative 2 DMTE0S3 MI TTQ6VDM DMTE0S3 MN Voltage-gated potassium channel Kv11.1 (KCNH2) DMTE0S3 MT DTT DMTE0S3 MA Ligand DMTE0S3 RN The sigma-2 (-2) receptor: a review of recent patent applications: 2013-2018.Expert Opin Ther Pat. 2018 Sep;28(9):655-663. DMTE0S3 RU https://www.ncbi.nlm.nih.gov/pubmed/30185082 DM2MYL9 DI DM2MYL9 DM2MYL9 DN Isoindoline derivative 3 DM2MYL9 MI TT5TPI6 DM2MYL9 MN Opioid receptor sigma 1 (OPRS1) DM2MYL9 MT DTT DM2MYL9 MA Ligand DM2MYL9 RN The sigma-2 (-2) receptor: a review of recent patent applications: 2013-2018.Expert Opin Ther Pat. 2018 Sep;28(9):655-663. DM2MYL9 RU https://www.ncbi.nlm.nih.gov/pubmed/30185082 DM2MYL9 DI DM2MYL9 DM2MYL9 DN Isoindoline derivative 3 DM2MYL9 MI TT9NXW4 DM2MYL9 MN Sigma intracellular receptor 2 (TMEM97) DM2MYL9 MT DTT DM2MYL9 MA Ligand DM2MYL9 RN The sigma-2 (-2) receptor: a review of recent patent applications: 2013-2018.Expert Opin Ther Pat. 2018 Sep;28(9):655-663. DM2MYL9 RU https://www.ncbi.nlm.nih.gov/pubmed/30185082 DM2MYL9 DI DM2MYL9 DM2MYL9 DN Isoindoline derivative 3 DM2MYL9 MI TTQ6VDM DM2MYL9 MN Voltage-gated potassium channel Kv11.1 (KCNH2) DM2MYL9 MT DTT DM2MYL9 MA Ligand DM2MYL9 RN The sigma-2 (-2) receptor: a review of recent patent applications: 2013-2018.Expert Opin Ther Pat. 2018 Sep;28(9):655-663. DM2MYL9 RU https://www.ncbi.nlm.nih.gov/pubmed/30185082 DMP1NKI DI DMP1NKI DMP1NKI DN Isoindoline derivative 4 DMP1NKI MI TT5TPI6 DMP1NKI MN Opioid receptor sigma 1 (OPRS1) DMP1NKI MT DTT DMP1NKI MA Ligand DMP1NKI RN The sigma-2 (-2) receptor: a review of recent patent applications: 2013-2018.Expert Opin Ther Pat. 2018 Sep;28(9):655-663. DMP1NKI RU https://www.ncbi.nlm.nih.gov/pubmed/30185082 DMP1NKI DI DMP1NKI DMP1NKI DN Isoindoline derivative 4 DMP1NKI MI TT9NXW4 DMP1NKI MN Sigma intracellular receptor 2 (TMEM97) DMP1NKI MT DTT DMP1NKI MA Ligand DMP1NKI RN The sigma-2 (-2) receptor: a review of recent patent applications: 2013-2018.Expert Opin Ther Pat. 2018 Sep;28(9):655-663. DMP1NKI RU https://www.ncbi.nlm.nih.gov/pubmed/30185082 DMP1NKI DI DMP1NKI DMP1NKI DN Isoindoline derivative 4 DMP1NKI MI TTQ6VDM DMP1NKI MN Voltage-gated potassium channel Kv11.1 (KCNH2) DMP1NKI MT DTT DMP1NKI MA Ligand DMP1NKI RN The sigma-2 (-2) receptor: a review of recent patent applications: 2013-2018.Expert Opin Ther Pat. 2018 Sep;28(9):655-663. DMP1NKI RU https://www.ncbi.nlm.nih.gov/pubmed/30185082 DMIUTQW DI DMIUTQW DMIUTQW DN Isoindoline derivative 5 DMIUTQW MI TT5TPI6 DMIUTQW MN Opioid receptor sigma 1 (OPRS1) DMIUTQW MT DTT DMIUTQW MA Ligand DMIUTQW RN The sigma-2 (-2) receptor: a review of recent patent applications: 2013-2018.Expert Opin Ther Pat. 2018 Sep;28(9):655-663. DMIUTQW RU https://www.ncbi.nlm.nih.gov/pubmed/30185082 DMIUTQW DI DMIUTQW DMIUTQW DN Isoindoline derivative 5 DMIUTQW MI TT9NXW4 DMIUTQW MN Sigma intracellular receptor 2 (TMEM97) DMIUTQW MT DTT DMIUTQW MA Ligand DMIUTQW RN The sigma-2 (-2) receptor: a review of recent patent applications: 2013-2018.Expert Opin Ther Pat. 2018 Sep;28(9):655-663. DMIUTQW RU https://www.ncbi.nlm.nih.gov/pubmed/30185082 DMIUTQW DI DMIUTQW DMIUTQW DN Isoindoline derivative 5 DMIUTQW MI TTQ6VDM DMIUTQW MN Voltage-gated potassium channel Kv11.1 (KCNH2) DMIUTQW MT DTT DMIUTQW MA Ligand DMIUTQW RN The sigma-2 (-2) receptor: a review of recent patent applications: 2013-2018.Expert Opin Ther Pat. 2018 Sep;28(9):655-663. DMIUTQW RU https://www.ncbi.nlm.nih.gov/pubmed/30185082 DMIYUAN DI DMIYUAN DMIYUAN DN Isoquinoline 1,3-dione derivative 1 DMIYUAN MI TTH6V3D DMIYUAN MN Cyclin-dependent kinase 1 (CDK1) DMIYUAN MT DTT DMIYUAN MA Inhibitor DMIYUAN RN Cyclin-dependent kinase inhibitors for cancer therapy: a patent review (2009 - 2014).Expert Opin Ther Pat. 2015;25(9):953-70. DMIYUAN RU https://www.ncbi.nlm.nih.gov/pubmed/26161698 DMIYUAN DI DMIYUAN DMIYUAN DN Isoquinoline 1,3-dione derivative 1 DMIYUAN MI TT7HF4W DMIYUAN MN Cyclin-dependent kinase 2 (CDK2) DMIYUAN MT DTT DMIYUAN MA Inhibitor DMIYUAN RN Cyclin-dependent kinase inhibitors for cancer therapy: a patent review (2009 - 2014).Expert Opin Ther Pat. 2015;25(9):953-70. DMIYUAN RU https://www.ncbi.nlm.nih.gov/pubmed/26161698 DMIYUAN DI DMIYUAN DMIYUAN DN Isoquinoline 1,3-dione derivative 1 DMIYUAN MI TT0PG8F DMIYUAN MN Cyclin-dependent kinase 4 (CDK4) DMIYUAN MT DTT DMIYUAN MA Inhibitor DMIYUAN RN Cyclin-dependent kinase inhibitors for cancer therapy: a patent review (2009 - 2014).Expert Opin Ther Pat. 2015;25(9):953-70. DMIYUAN RU https://www.ncbi.nlm.nih.gov/pubmed/26161698 DMIYUAN DI DMIYUAN DMIYUAN DN Isoquinoline 1,3-dione derivative 1 DMIYUAN MI TTO0FDJ DMIYUAN MN Cyclin-dependent kinase 6 (CDK6) DMIYUAN MT DTT DMIYUAN MA Inhibitor DMIYUAN RN Cyclin-dependent kinase inhibitors for cancer therapy: a patent review (2009 - 2014).Expert Opin Ther Pat. 2015;25(9):953-70. DMIYUAN RU https://www.ncbi.nlm.nih.gov/pubmed/26161698 DMOAY3Q DI DMOAY3Q DMOAY3Q DN Isoquinoline carboxamide derivative 1 DMOAY3Q MI TTPTXIN DMOAY3Q MN Translocator protein (TSPO) DMOAY3Q MT DTT DMOAY3Q MA Ligand DMOAY3Q RN Translocator protein (TSPO) ligands for the diagnosis or treatment of neurodegenerative diseases: a patent review (2010-2015; part 1).Expert Opin Ther Pat. 2016 Nov;26(11):1325-1351. DMOAY3Q RU https://www.ncbi.nlm.nih.gov/pubmed/27607364 DMR0Y3K DI DMR0Y3K DMR0Y3K DN Isoquinoline derivative 1 DMR0Y3K MI TTMSFAW DMR0Y3K MN Cannabinoid receptor 2 (CB2) DMR0Y3K MT DTT DMR0Y3K RN Cannabinoid receptor 2 (CB2) agonists and antagonists: a patent update.Expert Opin Ther Pat. 2016 Jul;26(7):843-56. DMR0Y3K RU https://www.ncbi.nlm.nih.gov/pubmed/27215781 DMRHBLD DI DMRHBLD DMRHBLD DN Isoquinoline derivative 2 DMRHBLD MI TTMSFAW DMRHBLD MN Cannabinoid receptor 2 (CB2) DMRHBLD MT DTT DMRHBLD RN Cannabinoid receptor 2 (CB2) agonists and antagonists: a patent update.Expert Opin Ther Pat. 2016 Jul;26(7):843-56. DMRHBLD RU https://www.ncbi.nlm.nih.gov/pubmed/27215781 DM4R1MK DI DM4R1MK DM4R1MK DN Isoquinoline derivative 3 DM4R1MK MI TTMSFAW DM4R1MK MN Cannabinoid receptor 2 (CB2) DM4R1MK MT DTT DM4R1MK RN Cannabinoid receptor 2 (CB2) agonists and antagonists: a patent update.Expert Opin Ther Pat. 2016 Jul;26(7):843-56. DM4R1MK RU https://www.ncbi.nlm.nih.gov/pubmed/27215781 DMB5F8Q DI DMB5F8Q DMB5F8Q DN Isoquinoline derivative 4 DMB5F8Q MI TTMQO60 DMB5F8Q MN Rho-associated protein kinase (ROCK) DMB5F8Q MT DTT DMB5F8Q MA Inhibitor DMB5F8Q RN Rho kinase inhibitors: a patent review (2014 - 2016).Expert Opin Ther Pat. 2017 Apr;27(4):507-515. DMB5F8Q RU https://www.ncbi.nlm.nih.gov/pubmed/28048944 DMNJ2R9 DI DMNJ2R9 DMNJ2R9 DN Isoquinoline derivative 5 DMNJ2R9 MI TTMQO60 DMNJ2R9 MN Rho-associated protein kinase (ROCK) DMNJ2R9 MT DTT DMNJ2R9 MA Inhibitor DMNJ2R9 RN Rho kinase inhibitors: a patent review (2014 - 2016).Expert Opin Ther Pat. 2017 Apr;27(4):507-515. DMNJ2R9 RU https://www.ncbi.nlm.nih.gov/pubmed/28048944 DMM5BDS DI DMM5BDS DMM5BDS DN Isoquinoline sulfonamide derivative 1 DMM5BDS MI TTMQO60 DMM5BDS MN Rho-associated protein kinase (ROCK) DMM5BDS MT DTT DMM5BDS MA Inhibitor DMM5BDS RN Rho kinase inhibitors: a patent review (2014 - 2016).Expert Opin Ther Pat. 2017 Apr;27(4):507-515. DMM5BDS RU https://www.ncbi.nlm.nih.gov/pubmed/28048944 DMQVYL0 DI DMQVYL0 DMQVYL0 DN Isoquinoline sulfonamide derivative 2 DMQVYL0 MI TTMQO60 DMQVYL0 MN Rho-associated protein kinase (ROCK) DMQVYL0 MT DTT DMQVYL0 MA Inhibitor DMQVYL0 RN Rho kinase inhibitors: a patent review (2014 - 2016).Expert Opin Ther Pat. 2017 Apr;27(4):507-515. DMQVYL0 RU https://www.ncbi.nlm.nih.gov/pubmed/28048944 DMC5F3H DI DMC5F3H DMC5F3H DN Isoquinoline sulfonyl derivative 1 DMC5F3H MI TTMQO60 DMC5F3H MN Rho-associated protein kinase (ROCK) DMC5F3H MT DTT DMC5F3H MA Inhibitor DMC5F3H RN Rho kinase inhibitors: a patent review (2014 - 2016).Expert Opin Ther Pat. 2017 Apr;27(4):507-515. DMC5F3H RU https://www.ncbi.nlm.nih.gov/pubmed/28048944 DMT5E7M DI DMT5E7M DMT5E7M DN Isoquinoline sulfonyl derivative 2 DMT5E7M MI TTMQO60 DMT5E7M MN Rho-associated protein kinase (ROCK) DMT5E7M MT DTT DMT5E7M MA Inhibitor DMT5E7M RN Rho kinase inhibitors: a patent review (2014 - 2016).Expert Opin Ther Pat. 2017 Apr;27(4):507-515. DMT5E7M RU https://www.ncbi.nlm.nih.gov/pubmed/28048944 DMHIAVW DI DMHIAVW DMHIAVW DN Isoquinoline sulfonyl derivative 3 DMHIAVW MI TTMQO60 DMHIAVW MN Rho-associated protein kinase (ROCK) DMHIAVW MT DTT DMHIAVW MA Inhibitor DMHIAVW RN Rho kinase inhibitors: a patent review (2014 - 2016).Expert Opin Ther Pat. 2017 Apr;27(4):507-515. DMHIAVW RU https://www.ncbi.nlm.nih.gov/pubmed/28048944 DMW6R0H DI DMW6R0H DMW6R0H DN Isoquinolone derivative 1 DMW6R0H MI TT5ZWB6 DMW6R0H MN Dihydrodiol dehydrogenase type I (AKR1C3) DMW6R0H MT DTT DMW6R0H MA Inhibitor; Antagonist; Blocker DMW6R0H RN Aldo-Keto Reductase (AKR) 1C3 inhibitors: a patent review.Expert Opin Ther Pat. 2017 Dec;27(12):1329-1340. DMW6R0H RU https://www.ncbi.nlm.nih.gov/pubmed/28895472 DMP2QDM DI DMP2QDM DMP2QDM DN Isosteric imidazolyl pyrimidine derivative 1 DMP2QDM MI TT7HF4W DMP2QDM MN Cyclin-dependent kinase 2 (CDK2) DMP2QDM MT DTT DMP2QDM MA Inhibitor DMP2QDM RN Cyclin-dependent kinase inhibitors for cancer therapy: a patent review (2009 - 2014).Expert Opin Ther Pat. 2015;25(9):953-70. DMP2QDM RU https://www.ncbi.nlm.nih.gov/pubmed/26161698 DMP2QDM DI DMP2QDM DMP2QDM DN Isosteric imidazolyl pyrimidine derivative 1 DMP2QDM MI TT6R7JZ DMP2QDM MN Histone deacetylase 1 (HDAC1) DMP2QDM MT DTT DMP2QDM MA Inhibitor DMP2QDM RN Cyclin-dependent kinase inhibitors for cancer therapy: a patent review (2009 - 2014).Expert Opin Ther Pat. 2015;25(9):953-70. DMP2QDM RU https://www.ncbi.nlm.nih.gov/pubmed/26161698 DMLSUH3 DI DMLSUH3 DMLSUH3 DN Isothiazolidine derivative 1 DMLSUH3 MI TT473XN DMLSUH3 MN P2X purinoceptor 7 (P2RX7) DMLSUH3 MT DTT DMLSUH3 MA Antagonist DMLSUH3 RN P2X7 receptor antagonists: a patent review (2010-2015).Expert Opin Ther Pat. 2017 Mar;27(3):257-267. DMLSUH3 RU https://www.ncbi.nlm.nih.gov/pubmed/27724045 DMHAJCM DI DMHAJCM DMHAJCM DN Isothiazolone derivative 1 DMHAJCM MI TTN9T81 DMHAJCM MN Arachidonate 15-lipoxygenase (15-LOX) DMHAJCM MT DTT DMHAJCM MA Inhibitor DMHAJCM RN 15-Lipoxygenase inhibitors: a patent review.Expert Opin Ther Pat. 2016;26(1):65-88. DMHAJCM RU https://www.ncbi.nlm.nih.gov/pubmed/26560362 DMK31M6 DI DMK31M6 DMK31M6 DN Isothiocyanate derivative 1 DMK31M6 MI TT2F4OL DMK31M6 MN Tissue transglutaminase (TG2) DMK31M6 MT DTT DMK31M6 MA Inhibitor DMK31M6 RN Transglutaminase inhibitors: a patent review.Expert Opin Ther Pat. 2016;26(1):49-63. DMK31M6 RU https://www.ncbi.nlm.nih.gov/pubmed/26560530 DMUMPZX DI DMUMPZX DMUMPZX DN Isoxazole derivative 1 DMUMPZX MI TT6DM01 DMUMPZX MN Janus kinase 1 (JAK-1) DMUMPZX MT DTT DMUMPZX MA Inhibitor DMUMPZX RN Inhibitors of JAK-family kinases: an update on the patent literature 2013-2015, part 2.Expert Opin Ther Pat. 2017 Feb;27(2):145-161. DMUMPZX RU https://www.ncbi.nlm.nih.gov/pubmed/27774822 DMUMPZX DI DMUMPZX DMUMPZX DN Isoxazole derivative 1 DMUMPZX MI TTRMX3V DMUMPZX MN Janus kinase 2 (JAK-2) DMUMPZX MT DTT DMUMPZX MA Inhibitor DMUMPZX RN Inhibitors of JAK-family kinases: an update on the patent literature 2013-2015, part 2.Expert Opin Ther Pat. 2017 Feb;27(2):145-161. DMUMPZX RU https://www.ncbi.nlm.nih.gov/pubmed/27774822 DMUMPZX DI DMUMPZX DMUMPZX DN Isoxazole derivative 1 DMUMPZX MI TTT7PJU DMUMPZX MN Janus kinase 3 (JAK-3) DMUMPZX MT DTT DMUMPZX MA Inhibitor DMUMPZX RN Inhibitors of JAK-family kinases: an update on the patent literature 2013-2015, part 2.Expert Opin Ther Pat. 2017 Feb;27(2):145-161. DMUMPZX RU https://www.ncbi.nlm.nih.gov/pubmed/27774822 DMT842O DI DMT842O DMT842O DN Isoxazole derivative 2 DMT842O MI TT6DM01 DMT842O MN Janus kinase 1 (JAK-1) DMT842O MT DTT DMT842O MA Inhibitor DMT842O RN Inhibitors of JAK-family kinases: an update on the patent literature 2013-2015, part 2.Expert Opin Ther Pat. 2017 Feb;27(2):145-161. DMT842O RU https://www.ncbi.nlm.nih.gov/pubmed/27774822 DMT842O DI DMT842O DMT842O DN Isoxazole derivative 2 DMT842O MI TTRMX3V DMT842O MN Janus kinase 2 (JAK-2) DMT842O MT DTT DMT842O MA Inhibitor DMT842O RN Inhibitors of JAK-family kinases: an update on the patent literature 2013-2015, part 2.Expert Opin Ther Pat. 2017 Feb;27(2):145-161. DMT842O RU https://www.ncbi.nlm.nih.gov/pubmed/27774822 DMT842O DI DMT842O DMT842O DN Isoxazole derivative 2 DMT842O MI TTT7PJU DMT842O MN Janus kinase 3 (JAK-3) DMT842O MT DTT DMT842O MA Inhibitor DMT842O RN Inhibitors of JAK-family kinases: an update on the patent literature 2013-2015, part 2.Expert Opin Ther Pat. 2017 Feb;27(2):145-161. DMT842O RU https://www.ncbi.nlm.nih.gov/pubmed/27774822 DM5CXQT DI DM5CXQT DM5CXQT DN Isoxazole-based bicyclic compound 1 DM5CXQT MI TTE4BSY DM5CXQT MN Bromodomain and extraterminal domain protein (BET) DM5CXQT MT DTT DM5CXQT MA Inhibitor DM5CXQT RN BET inhibitors in cancer therapeutics: a patent review.Expert Opin Ther Pat. 2016;26(4):505-22. DM5CXQT RU https://www.ncbi.nlm.nih.gov/pubmed/26924192 DMAYKZ9 DI DMAYKZ9 DMAYKZ9 DN Isoxazole-based bicyclic compound 10 DMAYKZ9 MI TTE4BSY DMAYKZ9 MN Bromodomain and extraterminal domain protein (BET) DMAYKZ9 MT DTT DMAYKZ9 MA Inhibitor DMAYKZ9 RN BET inhibitors in cancer therapeutics: a patent review.Expert Opin Ther Pat. 2016;26(4):505-22. DMAYKZ9 RU https://www.ncbi.nlm.nih.gov/pubmed/26924192 DM1G8SM DI DM1G8SM DM1G8SM DN Isoxazole-based bicyclic compound 11 DM1G8SM MI TTE4BSY DM1G8SM MN Bromodomain and extraterminal domain protein (BET) DM1G8SM MT DTT DM1G8SM MA Inhibitor DM1G8SM RN BET inhibitors in cancer therapeutics: a patent review.Expert Opin Ther Pat. 2016;26(4):505-22. DM1G8SM RU https://www.ncbi.nlm.nih.gov/pubmed/26924192 DMVA8KL DI DMVA8KL DMVA8KL DN Isoxazole-based bicyclic compound 12 DMVA8KL MI TTE4BSY DMVA8KL MN Bromodomain and extraterminal domain protein (BET) DMVA8KL MT DTT DMVA8KL MA Inhibitor DMVA8KL RN BET inhibitors in cancer therapeutics: a patent review.Expert Opin Ther Pat. 2016;26(4):505-22. DMVA8KL RU https://www.ncbi.nlm.nih.gov/pubmed/26924192 DM7OBVT DI DM7OBVT DM7OBVT DN Isoxazole-based bicyclic compound 13 DM7OBVT MI TTE4BSY DM7OBVT MN Bromodomain and extraterminal domain protein (BET) DM7OBVT MT DTT DM7OBVT MA Inhibitor DM7OBVT RN BET inhibitors in cancer therapeutics: a patent review.Expert Opin Ther Pat. 2016;26(4):505-22. DM7OBVT RU https://www.ncbi.nlm.nih.gov/pubmed/26924192 DMS3CDT DI DMS3CDT DMS3CDT DN Isoxazole-based bicyclic compound 14 DMS3CDT MI TTE4BSY DMS3CDT MN Bromodomain and extraterminal domain protein (BET) DMS3CDT MT DTT DMS3CDT MA Inhibitor DMS3CDT RN BET inhibitors in cancer therapeutics: a patent review.Expert Opin Ther Pat. 2016;26(4):505-22. DMS3CDT RU https://www.ncbi.nlm.nih.gov/pubmed/26924192 DMPXK1C DI DMPXK1C DMPXK1C DN Isoxazole-based bicyclic compound 15 DMPXK1C MI TTE4BSY DMPXK1C MN Bromodomain and extraterminal domain protein (BET) DMPXK1C MT DTT DMPXK1C MA Inhibitor DMPXK1C RN BET inhibitors in cancer therapeutics: a patent review.Expert Opin Ther Pat. 2016;26(4):505-22. DMPXK1C RU https://www.ncbi.nlm.nih.gov/pubmed/26924192 DM614F8 DI DM614F8 DM614F8 DN Isoxazole-based bicyclic compound 16 DM614F8 MI TTE4BSY DM614F8 MN Bromodomain and extraterminal domain protein (BET) DM614F8 MT DTT DM614F8 MA Inhibitor DM614F8 RN BET inhibitors in cancer therapeutics: a patent review.Expert Opin Ther Pat. 2016;26(4):505-22. DM614F8 RU https://www.ncbi.nlm.nih.gov/pubmed/26924192 DM2SUCK DI DM2SUCK DM2SUCK DN Isoxazole-based bicyclic compound 17 DM2SUCK MI TTE4BSY DM2SUCK MN Bromodomain and extraterminal domain protein (BET) DM2SUCK MT DTT DM2SUCK MA Inhibitor DM2SUCK RN BET inhibitors in cancer therapeutics: a patent review.Expert Opin Ther Pat. 2016;26(4):505-22. DM2SUCK RU https://www.ncbi.nlm.nih.gov/pubmed/26924192 DME8CQA DI DME8CQA DME8CQA DN Isoxazole-based bicyclic compound 18 DME8CQA MI TTE4BSY DME8CQA MN Bromodomain and extraterminal domain protein (BET) DME8CQA MT DTT DME8CQA MA Inhibitor DME8CQA RN BET inhibitors in cancer therapeutics: a patent review.Expert Opin Ther Pat. 2016;26(4):505-22. DME8CQA RU https://www.ncbi.nlm.nih.gov/pubmed/26924192 DM01FD3 DI DM01FD3 DM01FD3 DN Isoxazole-based bicyclic compound 19 DM01FD3 MI TTE4BSY DM01FD3 MN Bromodomain and extraterminal domain protein (BET) DM01FD3 MT DTT DM01FD3 MA Inhibitor DM01FD3 RN BET inhibitors in cancer therapeutics: a patent review.Expert Opin Ther Pat. 2016;26(4):505-22. DM01FD3 RU https://www.ncbi.nlm.nih.gov/pubmed/26924192 DMYLR2S DI DMYLR2S DMYLR2S DN Isoxazole-based bicyclic compound 2 DMYLR2S MI TTE4BSY DMYLR2S MN Bromodomain and extraterminal domain protein (BET) DMYLR2S MT DTT DMYLR2S MA Inhibitor DMYLR2S RN BET inhibitors in cancer therapeutics: a patent review.Expert Opin Ther Pat. 2016;26(4):505-22. DMYLR2S RU https://www.ncbi.nlm.nih.gov/pubmed/26924192 DMWMRKJ DI DMWMRKJ DMWMRKJ DN Isoxazole-based bicyclic compound 3 DMWMRKJ MI TTE4BSY DMWMRKJ MN Bromodomain and extraterminal domain protein (BET) DMWMRKJ MT DTT DMWMRKJ MA Inhibitor DMWMRKJ RN BET inhibitors in cancer therapeutics: a patent review.Expert Opin Ther Pat. 2016;26(4):505-22. DMWMRKJ RU https://www.ncbi.nlm.nih.gov/pubmed/26924192 DMNI0PH DI DMNI0PH DMNI0PH DN Isoxazole-based bicyclic compound 4 DMNI0PH MI TTE4BSY DMNI0PH MN Bromodomain and extraterminal domain protein (BET) DMNI0PH MT DTT DMNI0PH MA Inhibitor DMNI0PH RN BET inhibitors in cancer therapeutics: a patent review.Expert Opin Ther Pat. 2016;26(4):505-22. DMNI0PH RU https://www.ncbi.nlm.nih.gov/pubmed/26924192 DMT46PS DI DMT46PS DMT46PS DN Isoxazole-based bicyclic compound 5 DMT46PS MI TTE4BSY DMT46PS MN Bromodomain and extraterminal domain protein (BET) DMT46PS MT DTT DMT46PS MA Inhibitor DMT46PS RN BET inhibitors in cancer therapeutics: a patent review.Expert Opin Ther Pat. 2016;26(4):505-22. DMT46PS RU https://www.ncbi.nlm.nih.gov/pubmed/26924192 DMKSNZG DI DMKSNZG DMKSNZG DN Isoxazole-based bicyclic compound 6 DMKSNZG MI TTE4BSY DMKSNZG MN Bromodomain and extraterminal domain protein (BET) DMKSNZG MT DTT DMKSNZG MA Inhibitor DMKSNZG RN BET inhibitors in cancer therapeutics: a patent review.Expert Opin Ther Pat. 2016;26(4):505-22. DMKSNZG RU https://www.ncbi.nlm.nih.gov/pubmed/26924192 DM3T840 DI DM3T840 DM3T840 DN Isoxazole-based bicyclic compound 7 DM3T840 MI TTE4BSY DM3T840 MN Bromodomain and extraterminal domain protein (BET) DM3T840 MT DTT DM3T840 MA Inhibitor DM3T840 RN BET inhibitors in cancer therapeutics: a patent review.Expert Opin Ther Pat. 2016;26(4):505-22. DM3T840 RU https://www.ncbi.nlm.nih.gov/pubmed/26924192 DM3IV7K DI DM3IV7K DM3IV7K DN Isoxazole-based bicyclic compound 8 DM3IV7K MI TTE4BSY DM3IV7K MN Bromodomain and extraterminal domain protein (BET) DM3IV7K MT DTT DM3IV7K MA Inhibitor DM3IV7K RN BET inhibitors in cancer therapeutics: a patent review.Expert Opin Ther Pat. 2016;26(4):505-22. DM3IV7K RU https://www.ncbi.nlm.nih.gov/pubmed/26924192 DMWA7RB DI DMWA7RB DMWA7RB DN Isoxazole-based bicyclic compound 9 DMWA7RB MI TTE4BSY DMWA7RB MN Bromodomain and extraterminal domain protein (BET) DMWA7RB MT DTT DMWA7RB MA Inhibitor DMWA7RB RN BET inhibitors in cancer therapeutics: a patent review.Expert Opin Ther Pat. 2016;26(4):505-22. DMWA7RB RU https://www.ncbi.nlm.nih.gov/pubmed/26924192 DMRML9B DI DMRML9B DMRML9B DN Isoxazoles and isoxazoline derivative 1 DMRML9B MI TTIY56R DMRML9B MN Kynurenine 3-hydroxylase (KMO) DMRML9B MT DTT DMRML9B MA Inhibitor DMRML9B RN Inhibitors of the kynurenine pathway as neurotherapeutics: a patent review (2012-2015).Expert Opin Ther Pat. 2016 Jul;26(7):815-32. DMRML9B RU https://www.ncbi.nlm.nih.gov/pubmed/27172114 DMKCYSD DI DMKCYSD DMKCYSD DN Isoxazoles and isoxazoline derivative 2 DMKCYSD MI TTIY56R DMKCYSD MN Kynurenine 3-hydroxylase (KMO) DMKCYSD MT DTT DMKCYSD MA Inhibitor DMKCYSD RN Inhibitors of the kynurenine pathway as neurotherapeutics: a patent review (2012-2015).Expert Opin Ther Pat. 2016 Jul;26(7):815-32. DMKCYSD RU https://www.ncbi.nlm.nih.gov/pubmed/27172114 DMULJOS DI DMULJOS DMULJOS DN Isoxazoles and isoxazoline derivative 3 DMULJOS MI TTIY56R DMULJOS MN Kynurenine 3-hydroxylase (KMO) DMULJOS MT DTT DMULJOS MA Inhibitor DMULJOS RN Inhibitors of the kynurenine pathway as neurotherapeutics: a patent review (2012-2015).Expert Opin Ther Pat. 2016 Jul;26(7):815-32. DMULJOS RU https://www.ncbi.nlm.nih.gov/pubmed/27172114 DMW3JZV DI DMW3JZV DMW3JZV DN Isoxazoles and isoxazoline derivative 4 DMW3JZV MI TTIY56R DMW3JZV MN Kynurenine 3-hydroxylase (KMO) DMW3JZV MT DTT DMW3JZV MA Inhibitor DMW3JZV RN Inhibitors of the kynurenine pathway as neurotherapeutics: a patent review (2012-2015).Expert Opin Ther Pat. 2016 Jul;26(7):815-32. DMW3JZV RU https://www.ncbi.nlm.nih.gov/pubmed/27172114 DMCWFU1 DI DMCWFU1 DMCWFU1 DN Isoxazoles and isoxazoline derivative 5 DMCWFU1 MI TTIY56R DMCWFU1 MN Kynurenine 3-hydroxylase (KMO) DMCWFU1 MT DTT DMCWFU1 MA Inhibitor DMCWFU1 RN Inhibitors of the kynurenine pathway as neurotherapeutics: a patent review (2012-2015).Expert Opin Ther Pat. 2016 Jul;26(7):815-32. DMCWFU1 RU https://www.ncbi.nlm.nih.gov/pubmed/27172114 DMIKBV5 DI DMIKBV5 DMIKBV5 DN Isoxazoles and isoxazoline derivative 6 DMIKBV5 MI TTIY56R DMIKBV5 MN Kynurenine 3-hydroxylase (KMO) DMIKBV5 MT DTT DMIKBV5 MA Inhibitor DMIKBV5 RN Inhibitors of the kynurenine pathway as neurotherapeutics: a patent review (2012-2015).Expert Opin Ther Pat. 2016 Jul;26(7):815-32. DMIKBV5 RU https://www.ncbi.nlm.nih.gov/pubmed/27172114 DMLR8MS DI DMLR8MS DMLR8MS DN Isoxazoline derivative 1 DMLR8MS MI TTDP1UC DMLR8MS MN Fatty acid amide hydrolase (FAAH) DMLR8MS MT DTT DMLR8MS MA Inhibitor DMLR8MS RN Fatty acid amide hydrolase inhibitors: a patent review (2009-2014).Expert Opin Ther Pat. 2015;25(11):1247-66. DMLR8MS RU https://www.ncbi.nlm.nih.gov/pubmed/26413912 DMK5M8Q DI DMK5M8Q DMK5M8Q DN Isoxazoline derivative 2 DMK5M8Q MI TTDP1UC DMK5M8Q MN Fatty acid amide hydrolase (FAAH) DMK5M8Q MT DTT DMK5M8Q MA Inhibitor DMK5M8Q RN Fatty acid amide hydrolase inhibitors: a patent review (2009-2014).Expert Opin Ther Pat. 2015;25(11):1247-66. DMK5M8Q RU https://www.ncbi.nlm.nih.gov/pubmed/26413912 DMBVDHK DI DMBVDHK DMBVDHK DN Isoxazoline derivative 3 DMBVDHK MI TTDP1UC DMBVDHK MN Fatty acid amide hydrolase (FAAH) DMBVDHK MT DTT DMBVDHK MA Inhibitor DMBVDHK RN Fatty acid amide hydrolase inhibitors: a patent review (2009-2014).Expert Opin Ther Pat. 2015;25(11):1247-66. DMBVDHK RU https://www.ncbi.nlm.nih.gov/pubmed/26413912 DM01DG4 DI DM01DG4 DM01DG4 DN Isoxazoline derivative 4 DM01DG4 MI TTDP1UC DM01DG4 MN Fatty acid amide hydrolase (FAAH) DM01DG4 MT DTT DM01DG4 MA Inhibitor DM01DG4 RN Fatty acid amide hydrolase inhibitors: a patent review (2009-2014).Expert Opin Ther Pat. 2015;25(11):1247-66. DM01DG4 RU https://www.ncbi.nlm.nih.gov/pubmed/26413912 DMER7QX DI DMER7QX DMER7QX DN JCXGHZCWAHCYGY-UHFFFAOYSA-N DMER7QX MI TTDYP7I DMER7QX MN Sphingosine-1-phosphate receptor 3 (S1PR3) DMER7QX MT DTT DMER7QX MA Inhibitor DMER7QX RN 6-amino-pyrimidine-4-carboxamide derivatives and related compounds which bind to the sphingosine 1-phosphate (S1P) receptor for the treatment of multiple sclerosis. US9150519. DMER7QX RU http://www.freepatentsonline.com/US9150519.html DMS3HNM DI DMS3HNM DMS3HNM DN Jte 013 DMS3HNM MI TTVSMOH DMS3HNM MN Sphingosine-1-phosphate receptor 2 (S1PR2) DMS3HNM MT DTT DMS3HNM MA Inhibitor DMS3HNM RN Sphingosine 1-phosphate receptor antagonists. US9663511. DMS3HNM RU http://www.freepatentsonline.com/US9663511.html DMGTSCP DI DMGTSCP DMGTSCP DN JWH-015 DMGTSCP MI TTMSFAW DMGTSCP MN Cannabinoid receptor 2 (CB2) DMGTSCP MT DTT DMGTSCP MA Agonist DMGTSCP RN Posttraining activation of CB1 cannabinoid receptors in the CA1 region of the dorsal hippocampus impairs object recognition long-term memory. Neurobiol Learn Mem. 2008 Sep;90(2):374-81. DMGTSCP RU https://pubmed.ncbi.nlm.nih.gov/18524639 DM7UK5E DI DM7UK5E DM7UK5E DN KadcoccitoneA DM7UK5E MI TT3WG5C DM7UK5E MN Monoamine oxidase type A (MAO-A) DM7UK5E MT DTT DM7UK5E MA Inhibitor DM7UK5E RN Novel monoamine oxidase inhibitors: a patent review (2012 - 2014).Expert Opin Ther Pat. 2015 Jan;25(1):91-110. DM7UK5E RU https://www.ncbi.nlm.nih.gov/pubmed/25399762 DMAGVXW DI DMAGVXW DMAGVXW DN KENPAULLONE DMAGVXW MI TTH6V3D DMAGVXW MN Cyclin-dependent kinase 1 (CDK1) DMAGVXW MT DTT DMAGVXW MA Inhibitor DMAGVXW RN Discovery of novel CDK1 inhibitors by combining pharmacophore modeling, QSAR analysis and in silico screening followed by in vitro bioassay. Eur J Med Chem. 2010 Sep;45(9):4316-30. DMAGVXW RU https://pubmed.ncbi.nlm.nih.gov/20638755 DMAGVXW DI DMAGVXW DMAGVXW DN KENPAULLONE DMAGVXW MI TTL4Q97 DMAGVXW MN Cyclin-dependent kinase 5 (CDK5) DMAGVXW MT DTT DMAGVXW MA Inhibitor DMAGVXW RN 1-Azakenpaullone is a selective inhibitor of glycogen synthase kinase-3 beta. Bioorg Med Chem Lett. 2004 Jan 19;14(2):413-6. DMAGVXW RU https://pubmed.ncbi.nlm.nih.gov/14698171 DMAGVXW DI DMAGVXW DMAGVXW DN KENPAULLONE DMAGVXW MI TT9P6OW DMAGVXW MN G2/mitotic-specific cyclin B1 (CCNB1) DMAGVXW MT DTT DMAGVXW MA Inhibitor DMAGVXW RN Discovery of novel CDK1 inhibitors by combining pharmacophore modeling, QSAR analysis and in silico screening followed by in vitro bioassay. Eur J Med Chem. 2010 Sep;45(9):4316-30. DMAGVXW RU https://pubmed.ncbi.nlm.nih.gov/20638755 DMAGVXW DI DMAGVXW DMAGVXW DN KENPAULLONE DMAGVXW MI TTRZQE3 DMAGVXW MN Glycogen synthase kinase-3 alpha (GSK-3A) DMAGVXW MT DTT DMAGVXW MA Inhibitor DMAGVXW RN Glycogen synthase kinase 3 (GSK-3) inhibitors: a patent update (2014-2015).Expert Opin Ther Pat. 2017 Jun;27(6):657-666. DMAGVXW RU https://www.ncbi.nlm.nih.gov/pubmed/27828716 DMAGVXW DI DMAGVXW DMAGVXW DN KENPAULLONE DMAGVXW MI TTRSMW9 DMAGVXW MN Glycogen synthase kinase-3 beta (GSK-3B) DMAGVXW MT DTT DMAGVXW MA Inhibitor DMAGVXW RN 1-Azakenpaullone is a selective inhibitor of glycogen synthase kinase-3 beta. Bioorg Med Chem Lett. 2004 Jan 19;14(2):413-6. DMAGVXW RU https://pubmed.ncbi.nlm.nih.gov/14698171 DMAGVXW DI DMAGVXW DMAGVXW DN KENPAULLONE DMAGVXW MI TTSFWA7 DMAGVXW MN Plasmodium CDK Pfmrk (Malaria Pfmrk) DMAGVXW MT DTT DMAGVXW MA Inhibitor DMAGVXW RN A three-dimensional in silico pharmacophore model for inhibition of Plasmodium falciparum cyclin-dependent kinases and discovery of different class... J Med Chem. 2004 Oct 21;47(22):5418-26. DMAGVXW RU https://pubmed.ncbi.nlm.nih.gov/15481979 DM1ZK7E DI DM1ZK7E DM1ZK7E DN Ketoheterocycle derivative 1 DM1ZK7E MI TTDP1UC DM1ZK7E MN Fatty acid amide hydrolase (FAAH) DM1ZK7E MT DTT DM1ZK7E MA Inhibitor DM1ZK7E RN Fatty acid amide hydrolase inhibitors: a patent review (2009-2014).Expert Opin Ther Pat. 2015;25(11):1247-66. DM1ZK7E RU https://www.ncbi.nlm.nih.gov/pubmed/26413912 DM3KW2A DI DM3KW2A DM3KW2A DN Ketoheterocycle derivative 2 DM3KW2A MI TTDP1UC DM3KW2A MN Fatty acid amide hydrolase (FAAH) DM3KW2A MT DTT DM3KW2A MA Inhibitor DM3KW2A RN Fatty acid amide hydrolase inhibitors: a patent review (2009-2014).Expert Opin Ther Pat. 2015;25(11):1247-66. DM3KW2A RU https://www.ncbi.nlm.nih.gov/pubmed/26413912 DMFHD05 DI DMFHD05 DMFHD05 DN Ketoheterocycle derivative 3 DMFHD05 MI TTDP1UC DMFHD05 MN Fatty acid amide hydrolase (FAAH) DMFHD05 MT DTT DMFHD05 MA Inhibitor DMFHD05 RN Fatty acid amide hydrolase inhibitors: a patent review (2009-2014).Expert Opin Ther Pat. 2015;25(11):1247-66. DMFHD05 RU https://www.ncbi.nlm.nih.gov/pubmed/26413912 DM2LQXY DI DM2LQXY DM2LQXY DN Ketoheterocycle derivative 4 DM2LQXY MI TTDP1UC DM2LQXY MN Fatty acid amide hydrolase (FAAH) DM2LQXY MT DTT DM2LQXY MA Inhibitor DM2LQXY RN Fatty acid amide hydrolase inhibitors: a patent review (2009-2014).Expert Opin Ther Pat. 2015;25(11):1247-66. DM2LQXY RU https://www.ncbi.nlm.nih.gov/pubmed/26413912 DMRY7KV DI DMRY7KV DMRY7KV DN KRDULPYOVRWKMA-UHFFFAOYSA-N DMRY7KV MI TTIEMFN DMRY7KV MN TYRO3 tyrosine kinase receptor (TYRO3) DMRY7KV MT DTT DMRY7KV MA Inhibitor DMRY7KV RN Pyrrolopyrimidine derivatives as TAM inhibitors. US10053465. DMRY7KV RU http://www.freepatentsonline.com/US10053465.html DMDYKPC DI DMDYKPC DMDYKPC DN Lactam derivative 1 DMDYKPC MI TTF8P9I DMDYKPC MN Diacylglycerol acyltransferase 1 (DGAT1) DMDYKPC MT DTT DMDYKPC MA Inhibitor DMDYKPC RN Acyltransferase inhibitors: a patent review (2010-present).Expert Opin Ther Pat. 2015 Feb;25(2):145-58. DMDYKPC RU https://www.ncbi.nlm.nih.gov/pubmed/25470667 DMT58QE DI DMT58QE DMT58QE DN Lactam derivative 2 DMT58QE MI TTF8P9I DMT58QE MN Diacylglycerol acyltransferase 1 (DGAT1) DMT58QE MT DTT DMT58QE MA Inhibitor DMT58QE RN Acyltransferase inhibitors: a patent review (2010-present).Expert Opin Ther Pat. 2015 Feb;25(2):145-58. DMT58QE RU https://www.ncbi.nlm.nih.gov/pubmed/25470667 DMD0XIL DI DMD0XIL DMD0XIL DN Lactam derivative 3 DMD0XIL MI TTF8P9I DMD0XIL MN Diacylglycerol acyltransferase 1 (DGAT1) DMD0XIL MT DTT DMD0XIL MA Inhibitor DMD0XIL RN Acyltransferase inhibitors: a patent review (2010-present).Expert Opin Ther Pat. 2015 Feb;25(2):145-58. DMD0XIL RU https://www.ncbi.nlm.nih.gov/pubmed/25470667 DMJ3ZAI DI DMJ3ZAI DMJ3ZAI DN Lactam derivative 4 DMJ3ZAI MI TTF8P9I DMJ3ZAI MN Diacylglycerol acyltransferase 1 (DGAT1) DMJ3ZAI MT DTT DMJ3ZAI MA Inhibitor DMJ3ZAI RN Acyltransferase inhibitors: a patent review (2010-present).Expert Opin Ther Pat. 2015 Feb;25(2):145-58. DMJ3ZAI RU https://www.ncbi.nlm.nih.gov/pubmed/25470667 DMX5FYZ DI DMX5FYZ DMX5FYZ DN Lactam derivative 5 DMX5FYZ MI TTF8P9I DMX5FYZ MN Diacylglycerol acyltransferase 1 (DGAT1) DMX5FYZ MT DTT DMX5FYZ MA Inhibitor DMX5FYZ RN Acyltransferase inhibitors: a patent review (2010-present).Expert Opin Ther Pat. 2015 Feb;25(2):145-58. DMX5FYZ RU https://www.ncbi.nlm.nih.gov/pubmed/25470667 DMWC3P5 DI DMWC3P5 DMWC3P5 DN Lactol derivative 1 DMWC3P5 MI TTPADOQ DMWC3P5 MN HMG-CoA reductase (HMGCR) DMWC3P5 MT DTT DMWC3P5 MA Inhibitor DMWC3P5 RN HMG-CoA Reductase inhibitors: an updated review of patents of novel compounds and formulations (2011-2015).Expert Opin Ther Pat. 2016 Nov;26(11):1257-1272. DMWC3P5 RU https://www.ncbi.nlm.nih.gov/pubmed/27537201 DMP3GRA DI DMP3GRA DMP3GRA DN Lactol derivative 2 DMP3GRA MI TTPADOQ DMP3GRA MN HMG-CoA reductase (HMGCR) DMP3GRA MT DTT DMP3GRA MA Inhibitor DMP3GRA RN HMG-CoA Reductase inhibitors: an updated review of patents of novel compounds and formulations (2011-2015).Expert Opin Ther Pat. 2016 Nov;26(11):1257-1272. DMP3GRA RU https://www.ncbi.nlm.nih.gov/pubmed/27537201 DMCULK7 DI DMCULK7 DMCULK7 DN Lazabemide DMCULK7 MI TT32XQJ DMCULK7 MN Monoamine oxidase (MAO) DMCULK7 MT DTT DMCULK7 MA Inhibitor DMCULK7 RN Novel monoamine oxidase inhibitors: a patent review (2012 - 2014).Expert Opin Ther Pat. 2015 Jan;25(1):91-110. DMCULK7 RU https://www.ncbi.nlm.nih.gov/pubmed/25399762 DMCULK7 DI DMCULK7 DMCULK7 DN Lazabemide DMCULK7 MI TTGP7BY DMCULK7 MN Monoamine oxidase type B (MAO-B) DMCULK7 MT DTT DMCULK7 MA Inhibitor DMCULK7 RN The activity of MAO A and B in rat renal cells and tubules. Life Sci. 1998;62(8):727-37. DMCULK7 RU https://pubmed.ncbi.nlm.nih.gov/9489509 DM189D7 DI DM189D7 DM189D7 DN Lazabemide analog 1 DM189D7 MI TTGP7BY DM189D7 MN Monoamine oxidase type B (MAO-B) DM189D7 MT DTT DM189D7 MA Inhibitor DM189D7 RN MAO inhibitors and their wider applications: a patent review.Expert Opin Ther Pat. 2018 Mar;28(3):211-226. DM189D7 RU https://www.ncbi.nlm.nih.gov/pubmed/29324067 DM1STAD DI DM1STAD DM1STAD DN L-piperazino-3-phenyl-indane derivative 1 DM1STAD MI TTJQOD7 DM1STAD MN 5-HT 2A receptor (HTR2A) DM1STAD MT DTT DM1STAD MA Antagonist DM1STAD RN Novel serotonin receptor 2 (5-HT2R) agonists and antagonists: a patent review (2004-2014).Expert Opin Ther Pat. 2016;26(1):89-106. DM1STAD RU https://www.ncbi.nlm.nih.gov/pubmed/26609882 DM1STAD DI DM1STAD DM1STAD DN L-piperazino-3-phenyl-indane derivative 1 DM1STAD MI TTEX248 DM1STAD MN Dopamine D2 receptor (D2R) DM1STAD MT DTT DM1STAD MA Antagonist DM1STAD RN Novel serotonin receptor 2 (5-HT2R) agonists and antagonists: a patent review (2004-2014).Expert Opin Ther Pat. 2016;26(1):89-106. DM1STAD RU https://www.ncbi.nlm.nih.gov/pubmed/26609882 DM1STAD DI DM1STAD DM1STAD DN L-piperazino-3-phenyl-indane derivative 1 DM1STAD MI TTWFZ1N DM1STAD MN Dopamine receptor (DR) DM1STAD MT DTT DM1STAD MA Antagonist DM1STAD RN Novel serotonin receptor 2 (5-HT2R) agonists and antagonists: a patent review (2004-2014).Expert Opin Ther Pat. 2016;26(1):89-106. DM1STAD RU https://www.ncbi.nlm.nih.gov/pubmed/26609882 DMGKQXP DI DMGKQXP DMGKQXP DN Lycorine dimer salt derivative 1 DMGKQXP MI TT1RS9F DMGKQXP MN Acetylcholinesterase (AChE) DMGKQXP MT DTT DMGKQXP MA Inhibitor DMGKQXP RN Recent advances in acetylcholinesterase Inhibitors and Reactivators: an update on the patent literature (2012-2015).Expert Opin Ther Pat. 2017 Apr;27(4):455-476. DMGKQXP RU https://www.ncbi.nlm.nih.gov/pubmed/27967267 DMN7I9C DI DMN7I9C DMN7I9C DN Macrocycle derivative 1 DMN7I9C MI TT5YPJF DMN7I9C MN CD80-PD-L1 interaction (CD80/PD-L1 PPI) DMN7I9C MT DTT DMN7I9C MA Inhibitor DMN7I9C RN A patent review on PD-1/PD-L1 antagonists: small molecules, peptides, and macrocycles (2015-2018).Expert Opin Ther Pat. 2018 Sep;28(9):665-678. DMN7I9C RU https://www.ncbi.nlm.nih.gov/pubmed/30107136 DMN7I9C DI DMN7I9C DMN7I9C DN Macrocycle derivative 1 DMN7I9C MI TT23XQV DMN7I9C MN PD-1-PD-L1 interaction (PD-1/PD-L1 PPI) DMN7I9C MT DTT DMN7I9C MA Inhibitor DMN7I9C RN A patent review on PD-1/PD-L1 antagonists: small molecules, peptides, and macrocycles (2015-2018).Expert Opin Ther Pat. 2018 Sep;28(9):665-678. DMN7I9C RU https://www.ncbi.nlm.nih.gov/pubmed/30107136 DM1KBSV DI DM1KBSV DM1KBSV DN Macrocycle derivative 13 DM1KBSV MI TTKN7QR DM1KBSV MN BDNF/NT-3 growth factors receptor (TrkB) DM1KBSV MT DTT DM1KBSV MA Inhibitor DM1KBSV RN Tropomyosin receptor kinase inhibitors: an updated patent review for 2010-2016 - Part I.Expert Opin Ther Pat. 2017 Jun;27(6):733-751. DM1KBSV RU https://www.ncbi.nlm.nih.gov/pubmed/28270010 DMXSRPH DI DMXSRPH DMXSRPH DN Macrocycle derivative 14 DMXSRPH MI TTBJR4L DMXSRPH MN Cyclin-dependent kinase 8 (CDK8) DMXSRPH MT DTT DMXSRPH MA Inhibitor DMXSRPH RN Cyclin-dependent kinase inhibitors for cancer therapy: a patent review (2009 - 2014).Expert Opin Ther Pat. 2015;25(9):953-70. DMXSRPH RU https://www.ncbi.nlm.nih.gov/pubmed/26161698 DM5OEQZ DI DM5OEQZ DM5OEQZ DN Macrocycle derivative 2 DM5OEQZ MI TT5YPJF DM5OEQZ MN CD80-PD-L1 interaction (CD80/PD-L1 PPI) DM5OEQZ MT DTT DM5OEQZ MA Inhibitor DM5OEQZ RN A patent review on PD-1/PD-L1 antagonists: small molecules, peptides, and macrocycles (2015-2018).Expert Opin Ther Pat. 2018 Sep;28(9):665-678. DM5OEQZ RU https://www.ncbi.nlm.nih.gov/pubmed/30107136 DM5OEQZ DI DM5OEQZ DM5OEQZ DN Macrocycle derivative 2 DM5OEQZ MI TT23XQV DM5OEQZ MN PD-1-PD-L1 interaction (PD-1/PD-L1 PPI) DM5OEQZ MT DTT DM5OEQZ MA Inhibitor DM5OEQZ RN A patent review on PD-1/PD-L1 antagonists: small molecules, peptides, and macrocycles (2015-2018).Expert Opin Ther Pat. 2018 Sep;28(9):665-678. DM5OEQZ RU https://www.ncbi.nlm.nih.gov/pubmed/30107136 DMYGFTI DI DMYGFTI DMYGFTI DN Macrocycle derivative 3 DMYGFTI MI TT5YPJF DMYGFTI MN CD80-PD-L1 interaction (CD80/PD-L1 PPI) DMYGFTI MT DTT DMYGFTI MA Inhibitor DMYGFTI RN A patent review on PD-1/PD-L1 antagonists: small molecules, peptides, and macrocycles (2015-2018).Expert Opin Ther Pat. 2018 Sep;28(9):665-678. DMYGFTI RU https://www.ncbi.nlm.nih.gov/pubmed/30107136 DMYGFTI DI DMYGFTI DMYGFTI DN Macrocycle derivative 3 DMYGFTI MI TT23XQV DMYGFTI MN PD-1-PD-L1 interaction (PD-1/PD-L1 PPI) DMYGFTI MT DTT DMYGFTI MA Inhibitor DMYGFTI RN A patent review on PD-1/PD-L1 antagonists: small molecules, peptides, and macrocycles (2015-2018).Expert Opin Ther Pat. 2018 Sep;28(9):665-678. DMYGFTI RU https://www.ncbi.nlm.nih.gov/pubmed/30107136 DMOQBN4 DI DMOQBN4 DMOQBN4 DN Macrocycle derivative 4 DMOQBN4 MI TT5YPJF DMOQBN4 MN CD80-PD-L1 interaction (CD80/PD-L1 PPI) DMOQBN4 MT DTT DMOQBN4 MA Inhibitor DMOQBN4 RN A patent review on PD-1/PD-L1 antagonists: small molecules, peptides, and macrocycles (2015-2018).Expert Opin Ther Pat. 2018 Sep;28(9):665-678. DMOQBN4 RU https://www.ncbi.nlm.nih.gov/pubmed/30107136 DMOQBN4 DI DMOQBN4 DMOQBN4 DN Macrocycle derivative 4 DMOQBN4 MI TT23XQV DMOQBN4 MN PD-1-PD-L1 interaction (PD-1/PD-L1 PPI) DMOQBN4 MT DTT DMOQBN4 MA Inhibitor DMOQBN4 RN A patent review on PD-1/PD-L1 antagonists: small molecules, peptides, and macrocycles (2015-2018).Expert Opin Ther Pat. 2018 Sep;28(9):665-678. DMOQBN4 RU https://www.ncbi.nlm.nih.gov/pubmed/30107136 DMK3UJY DI DMK3UJY DMK3UJY DN Macrocycle derivative 5 DMK3UJY MI TT5YPJF DMK3UJY MN CD80-PD-L1 interaction (CD80/PD-L1 PPI) DMK3UJY MT DTT DMK3UJY MA Inhibitor DMK3UJY RN A patent review on PD-1/PD-L1 antagonists: small molecules, peptides, and macrocycles (2015-2018).Expert Opin Ther Pat. 2018 Sep;28(9):665-678. DMK3UJY RU https://www.ncbi.nlm.nih.gov/pubmed/30107136 DMK3UJY DI DMK3UJY DMK3UJY DN Macrocycle derivative 5 DMK3UJY MI TT23XQV DMK3UJY MN PD-1-PD-L1 interaction (PD-1/PD-L1 PPI) DMK3UJY MT DTT DMK3UJY MA Inhibitor DMK3UJY RN A patent review on PD-1/PD-L1 antagonists: small molecules, peptides, and macrocycles (2015-2018).Expert Opin Ther Pat. 2018 Sep;28(9):665-678. DMK3UJY RU https://www.ncbi.nlm.nih.gov/pubmed/30107136 DMQ84KW DI DMQ84KW DMQ84KW DN Macrocycle derivative 6 DMQ84KW MI TT5YPJF DMQ84KW MN CD80-PD-L1 interaction (CD80/PD-L1 PPI) DMQ84KW MT DTT DMQ84KW MA Inhibitor DMQ84KW RN A patent review on PD-1/PD-L1 antagonists: small molecules, peptides, and macrocycles (2015-2018).Expert Opin Ther Pat. 2018 Sep;28(9):665-678. DMQ84KW RU https://www.ncbi.nlm.nih.gov/pubmed/30107136 DMQ84KW DI DMQ84KW DMQ84KW DN Macrocycle derivative 6 DMQ84KW MI TT23XQV DMQ84KW MN PD-1-PD-L1 interaction (PD-1/PD-L1 PPI) DMQ84KW MT DTT DMQ84KW MA Inhibitor DMQ84KW RN A patent review on PD-1/PD-L1 antagonists: small molecules, peptides, and macrocycles (2015-2018).Expert Opin Ther Pat. 2018 Sep;28(9):665-678. DMQ84KW RU https://www.ncbi.nlm.nih.gov/pubmed/30107136 DMP2JF0 DI DMP2JF0 DMP2JF0 DN Macrocycle derivative 7 DMP2JF0 MI TT5YPJF DMP2JF0 MN CD80-PD-L1 interaction (CD80/PD-L1 PPI) DMP2JF0 MT DTT DMP2JF0 MA Inhibitor DMP2JF0 RN A patent review on PD-1/PD-L1 antagonists: small molecules, peptides, and macrocycles (2015-2018).Expert Opin Ther Pat. 2018 Sep;28(9):665-678. DMP2JF0 RU https://www.ncbi.nlm.nih.gov/pubmed/30107136 DMP2JF0 DI DMP2JF0 DMP2JF0 DN Macrocycle derivative 7 DMP2JF0 MI TT23XQV DMP2JF0 MN PD-1-PD-L1 interaction (PD-1/PD-L1 PPI) DMP2JF0 MT DTT DMP2JF0 MA Inhibitor DMP2JF0 RN A patent review on PD-1/PD-L1 antagonists: small molecules, peptides, and macrocycles (2015-2018).Expert Opin Ther Pat. 2018 Sep;28(9):665-678. DMP2JF0 RU https://www.ncbi.nlm.nih.gov/pubmed/30107136 DMOMTBE DI DMOMTBE DMOMTBE DN Macrocycle derivative 8 DMOMTBE MI TT5YPJF DMOMTBE MN CD80-PD-L1 interaction (CD80/PD-L1 PPI) DMOMTBE MT DTT DMOMTBE MA Inhibitor DMOMTBE RN A patent review on PD-1/PD-L1 antagonists: small molecules, peptides, and macrocycles (2015-2018).Expert Opin Ther Pat. 2018 Sep;28(9):665-678. DMOMTBE RU https://www.ncbi.nlm.nih.gov/pubmed/30107136 DMOMTBE DI DMOMTBE DMOMTBE DN Macrocycle derivative 8 DMOMTBE MI TT23XQV DMOMTBE MN PD-1-PD-L1 interaction (PD-1/PD-L1 PPI) DMOMTBE MT DTT DMOMTBE MA Inhibitor DMOMTBE RN A patent review on PD-1/PD-L1 antagonists: small molecules, peptides, and macrocycles (2015-2018).Expert Opin Ther Pat. 2018 Sep;28(9):665-678. DMOMTBE RU https://www.ncbi.nlm.nih.gov/pubmed/30107136 DMARU0E DI DMARU0E DMARU0E DN Macrocycle derivative 9 DMARU0E MI TT5YPJF DMARU0E MN CD80-PD-L1 interaction (CD80/PD-L1 PPI) DMARU0E MT DTT DMARU0E MA Inhibitor DMARU0E RN A patent review on PD-1/PD-L1 antagonists: small molecules, peptides, and macrocycles (2015-2018).Expert Opin Ther Pat. 2018 Sep;28(9):665-678. DMARU0E RU https://www.ncbi.nlm.nih.gov/pubmed/30107136 DMARU0E DI DMARU0E DMARU0E DN Macrocycle derivative 9 DMARU0E MI TT23XQV DMARU0E MN PD-1-PD-L1 interaction (PD-1/PD-L1 PPI) DMARU0E MT DTT DMARU0E MA Inhibitor DMARU0E RN A patent review on PD-1/PD-L1 antagonists: small molecules, peptides, and macrocycles (2015-2018).Expert Opin Ther Pat. 2018 Sep;28(9):665-678. DMARU0E RU https://www.ncbi.nlm.nih.gov/pubmed/30107136 DMS65IT DI DMS65IT DMS65IT DN Macrocyclic peptide analog 1 DMS65IT MI TT23XQV DMS65IT MN PD-1-PD-L1 interaction (PD-1/PD-L1 PPI) DMS65IT MT DTT DMS65IT MA Inhibitor DMS65IT RN A patent review on PD-1/PD-L1 antagonists: small molecules, peptides, and macrocycles (2015-2018).Expert Opin Ther Pat. 2018 Sep;28(9):665-678. DMS65IT RU https://www.ncbi.nlm.nih.gov/pubmed/30107136 DMOGLBZ DI DMOGLBZ DMOGLBZ DN Macrocyclic peptide analog 2 DMOGLBZ MI TT23XQV DMOGLBZ MN PD-1-PD-L1 interaction (PD-1/PD-L1 PPI) DMOGLBZ MT DTT DMOGLBZ MA Inhibitor DMOGLBZ RN A patent review on PD-1/PD-L1 antagonists: small molecules, peptides, and macrocycles (2015-2018).Expert Opin Ther Pat. 2018 Sep;28(9):665-678. DMOGLBZ RU https://www.ncbi.nlm.nih.gov/pubmed/30107136 DMV172W DI DMV172W DMV172W DN Macrocyclic peptide analog 3 DMV172W MI TT23XQV DMV172W MN PD-1-PD-L1 interaction (PD-1/PD-L1 PPI) DMV172W MT DTT DMV172W MA Inhibitor DMV172W RN A patent review on PD-1/PD-L1 antagonists: small molecules, peptides, and macrocycles (2015-2018).Expert Opin Ther Pat. 2018 Sep;28(9):665-678. DMV172W RU https://www.ncbi.nlm.nih.gov/pubmed/30107136 DM0ON7S DI DM0ON7S DM0ON7S DN Macrolactam derivative 1 DM0ON7S MI TTKFVXR DM0ON7S MN Renal carcinoma antigen NY-REN-64 (IRAK-4) DM0ON7S MT DTT DM0ON7S MA Inhibitor DM0ON7S RN Inhibitors of interleukin-1 receptor-associated kinase 4 (IRAK4): a patent review (2012-2015).Expert Opin Ther Pat. 2016 Aug;26(8):917-32. DM0ON7S RU https://www.ncbi.nlm.nih.gov/pubmed/27310003 DME72VA DI DME72VA DME72VA DN Macrolactam derivative 2 DME72VA MI TTKFVXR DME72VA MN Renal carcinoma antigen NY-REN-64 (IRAK-4) DME72VA MT DTT DME72VA MA Inhibitor DME72VA RN Inhibitors of interleukin-1 receptor-associated kinase 4 (IRAK4): a patent review (2012-2015).Expert Opin Ther Pat. 2016 Aug;26(8):917-32. DME72VA RU https://www.ncbi.nlm.nih.gov/pubmed/27310003 DMFNGUV DI DMFNGUV DMFNGUV DN Macrolactam derivative 3 DMFNGUV MI TTKFVXR DMFNGUV MN Renal carcinoma antigen NY-REN-64 (IRAK-4) DMFNGUV MT DTT DMFNGUV MA Inhibitor DMFNGUV RN Inhibitors of interleukin-1 receptor-associated kinase 4 (IRAK4): a patent review (2012-2015).Expert Opin Ther Pat. 2016 Aug;26(8):917-32. DMFNGUV RU https://www.ncbi.nlm.nih.gov/pubmed/27310003 DM5AXHF DI DM5AXHF DM5AXHF DN Macrolactam derivative 4 DM5AXHF MI TTKFVXR DM5AXHF MN Renal carcinoma antigen NY-REN-64 (IRAK-4) DM5AXHF MT DTT DM5AXHF MA Inhibitor DM5AXHF RN Inhibitors of interleukin-1 receptor-associated kinase 4 (IRAK4): a patent review (2012-2015).Expert Opin Ther Pat. 2016 Aug;26(8):917-32. DM5AXHF RU https://www.ncbi.nlm.nih.gov/pubmed/27310003 DMINM8F DI DMINM8F DMINM8F DN Maleimides derivative 1 DMINM8F MI TTRZQE3 DMINM8F MN Glycogen synthase kinase-3 alpha (GSK-3A) DMINM8F MT DTT DMINM8F MA Inhibitor DMINM8F RN Glycogen synthase kinase 3 (GSK-3) inhibitors: a patent update (2014-2015).Expert Opin Ther Pat. 2017 Jun;27(6):657-666. DMINM8F RU https://www.ncbi.nlm.nih.gov/pubmed/27828716 DMUVYWE DI DMUVYWE DMUVYWE DN Maleimides derivative 2 DMUVYWE MI TTRZQE3 DMUVYWE MN Glycogen synthase kinase-3 alpha (GSK-3A) DMUVYWE MT DTT DMUVYWE RN Glycogen synthase kinase 3 (GSK-3) inhibitors: a patent update (2014-2015).Expert Opin Ther Pat. 2017 Jun;27(6):657-666. DMUVYWE RU https://www.ncbi.nlm.nih.gov/pubmed/27828716 DMEFQND DI DMEFQND DMEFQND DN Maleimides derivative 3 DMEFQND MI TTRZQE3 DMEFQND MN Glycogen synthase kinase-3 alpha (GSK-3A) DMEFQND MT DTT DMEFQND MA Inhibitor DMEFQND RN Glycogen synthase kinase 3 (GSK-3) inhibitors: a patent update (2014-2015).Expert Opin Ther Pat. 2017 Jun;27(6):657-666. DMEFQND RU https://www.ncbi.nlm.nih.gov/pubmed/27828716 DMIE7U3 DI DMIE7U3 DMIE7U3 DN Mannoside derivative 1 DMIE7U3 MI TTTCRU2 DMIE7U3 MN Bacterial Fimbrin D-mannose adhesin (Bact FimH) DMIE7U3 MT DTT DMIE7U3 MA Antagonist DMIE7U3 RN Mannose-derived FimH antagonists: a promising anti-virulence therapeutic strategy for urinary tract infections and Crohn's disease.Expert Opin Ther Pat. 2016;26(2):175-97. DMIE7U3 RU https://www.ncbi.nlm.nih.gov/pubmed/26651364 DMZYRHN DI DMZYRHN DMZYRHN DN Mannoside derivative 10 DMZYRHN MI TTTCRU2 DMZYRHN MN Bacterial Fimbrin D-mannose adhesin (Bact FimH) DMZYRHN MT DTT DMZYRHN MA Antagonist DMZYRHN RN Mannose-derived FimH antagonists: a promising anti-virulence therapeutic strategy for urinary tract infections and Crohn's disease.Expert Opin Ther Pat. 2016;26(2):175-97. DMZYRHN RU https://www.ncbi.nlm.nih.gov/pubmed/26651364 DM8I051 DI DM8I051 DM8I051 DN Mannoside derivative 11 DM8I051 MI TTTCRU2 DM8I051 MN Bacterial Fimbrin D-mannose adhesin (Bact FimH) DM8I051 MT DTT DM8I051 MA Antagonist DM8I051 RN Mannose-derived FimH antagonists: a promising anti-virulence therapeutic strategy for urinary tract infections and Crohn's disease.Expert Opin Ther Pat. 2016;26(2):175-97. DM8I051 RU https://www.ncbi.nlm.nih.gov/pubmed/26651364 DM4QUY0 DI DM4QUY0 DM4QUY0 DN Mannoside derivative 12 DM4QUY0 MI TTTCRU2 DM4QUY0 MN Bacterial Fimbrin D-mannose adhesin (Bact FimH) DM4QUY0 MT DTT DM4QUY0 MA Antagonist DM4QUY0 RN Mannose-derived FimH antagonists: a promising anti-virulence therapeutic strategy for urinary tract infections and Crohn's disease.Expert Opin Ther Pat. 2016;26(2):175-97. DM4QUY0 RU https://www.ncbi.nlm.nih.gov/pubmed/26651364 DM0U7P9 DI DM0U7P9 DM0U7P9 DN Mannoside derivative 13 DM0U7P9 MI TTTCRU2 DM0U7P9 MN Bacterial Fimbrin D-mannose adhesin (Bact FimH) DM0U7P9 MT DTT DM0U7P9 MA Antagonist DM0U7P9 RN Mannose-derived FimH antagonists: a promising anti-virulence therapeutic strategy for urinary tract infections and Crohn's disease.Expert Opin Ther Pat. 2016;26(2):175-97. DM0U7P9 RU https://www.ncbi.nlm.nih.gov/pubmed/26651364 DMFEQD2 DI DMFEQD2 DMFEQD2 DN Mannoside derivative 2 DMFEQD2 MI TTTCRU2 DMFEQD2 MN Bacterial Fimbrin D-mannose adhesin (Bact FimH) DMFEQD2 MT DTT DMFEQD2 MA Antagonist DMFEQD2 RN Mannose-derived FimH antagonists: a promising anti-virulence therapeutic strategy for urinary tract infections and Crohn's disease.Expert Opin Ther Pat. 2016;26(2):175-97. DMFEQD2 RU https://www.ncbi.nlm.nih.gov/pubmed/26651364 DMPF2UG DI DMPF2UG DMPF2UG DN Mannoside derivative 3 DMPF2UG MI TTTCRU2 DMPF2UG MN Bacterial Fimbrin D-mannose adhesin (Bact FimH) DMPF2UG MT DTT DMPF2UG MA Antagonist DMPF2UG RN Mannose-derived FimH antagonists: a promising anti-virulence therapeutic strategy for urinary tract infections and Crohn's disease.Expert Opin Ther Pat. 2016;26(2):175-97. DMPF2UG RU https://www.ncbi.nlm.nih.gov/pubmed/26651364 DMZBY73 DI DMZBY73 DMZBY73 DN Mannoside derivative 4 DMZBY73 MI TTTCRU2 DMZBY73 MN Bacterial Fimbrin D-mannose adhesin (Bact FimH) DMZBY73 MT DTT DMZBY73 MA Antagonist DMZBY73 RN Mannose-derived FimH antagonists: a promising anti-virulence therapeutic strategy for urinary tract infections and Crohn's disease.Expert Opin Ther Pat. 2016;26(2):175-97. DMZBY73 RU https://www.ncbi.nlm.nih.gov/pubmed/26651364 DMMXNY8 DI DMMXNY8 DMMXNY8 DN Mannoside derivative 5 DMMXNY8 MI TTTCRU2 DMMXNY8 MN Bacterial Fimbrin D-mannose adhesin (Bact FimH) DMMXNY8 MT DTT DMMXNY8 MA Antagonist DMMXNY8 RN Mannose-derived FimH antagonists: a promising anti-virulence therapeutic strategy for urinary tract infections and Crohn's disease.Expert Opin Ther Pat. 2016;26(2):175-97. DMMXNY8 RU https://www.ncbi.nlm.nih.gov/pubmed/26651364 DMCM3NW DI DMCM3NW DMCM3NW DN Mannoside derivative 6 DMCM3NW MI TTTCRU2 DMCM3NW MN Bacterial Fimbrin D-mannose adhesin (Bact FimH) DMCM3NW MT DTT DMCM3NW MA Antagonist DMCM3NW RN Mannose-derived FimH antagonists: a promising anti-virulence therapeutic strategy for urinary tract infections and Crohn's disease.Expert Opin Ther Pat. 2016;26(2):175-97. DMCM3NW RU https://www.ncbi.nlm.nih.gov/pubmed/26651364 DMOUT1F DI DMOUT1F DMOUT1F DN Mannoside derivative 7 DMOUT1F MI TTTCRU2 DMOUT1F MN Bacterial Fimbrin D-mannose adhesin (Bact FimH) DMOUT1F MT DTT DMOUT1F MA Antagonist DMOUT1F RN Mannose-derived FimH antagonists: a promising anti-virulence therapeutic strategy for urinary tract infections and Crohn's disease.Expert Opin Ther Pat. 2016;26(2):175-97. DMOUT1F RU https://www.ncbi.nlm.nih.gov/pubmed/26651364 DMKTJAH DI DMKTJAH DMKTJAH DN Mannoside derivative 8 DMKTJAH MI TTTCRU2 DMKTJAH MN Bacterial Fimbrin D-mannose adhesin (Bact FimH) DMKTJAH MT DTT DMKTJAH MA Antagonist DMKTJAH RN Mannose-derived FimH antagonists: a promising anti-virulence therapeutic strategy for urinary tract infections and Crohn's disease.Expert Opin Ther Pat. 2016;26(2):175-97. DMKTJAH RU https://www.ncbi.nlm.nih.gov/pubmed/26651364 DMIKZXD DI DMIKZXD DMIKZXD DN Mannoside derivative 9 DMIKZXD MI TTTCRU2 DMIKZXD MN Bacterial Fimbrin D-mannose adhesin (Bact FimH) DMIKZXD MT DTT DMIKZXD MA Antagonist DMIKZXD RN Mannose-derived FimH antagonists: a promising anti-virulence therapeutic strategy for urinary tract infections and Crohn's disease.Expert Opin Ther Pat. 2016;26(2):175-97. DMIKZXD RU https://www.ncbi.nlm.nih.gov/pubmed/26651364 DMMCS9P DI DMMCS9P DMMCS9P DN Matairesinol derivative 1 DMMCS9P MI TTUX68I DMMCS9P MN Hypoxia-inducible factor 1 (HIF-1) DMMCS9P MT DTT DMMCS9P MA Inhibitor DMMCS9P RN Hypoxia-inducible factor (HIF) inhibitors: a patent survey (2011-2015).Expert Opin Ther Pat. 2016;26(3):309-22. DMMCS9P RU https://www.ncbi.nlm.nih.gov/pubmed/26882240 DMUOW3T DI DMUOW3T DMUOW3T DN Metal complex derivative 1 DMUOW3T MI TTR7UJ3 DMUOW3T MN Cytoplasmic thioredoxin reductase (TXNRD1) DMUOW3T MT DTT DMUOW3T MA Inhibitor DMUOW3T RN Thioredoxin reductase inhibitors: a patent review.Expert Opin Ther Pat. 2017 May;27(5):547-556. DMUOW3T RU https://www.ncbi.nlm.nih.gov/pubmed/27977313 DM0BTH8 DI DM0BTH8 DM0BTH8 DN Metal complex derivative 2 DM0BTH8 MI TTR7UJ3 DM0BTH8 MN Cytoplasmic thioredoxin reductase (TXNRD1) DM0BTH8 MT DTT DM0BTH8 MA Inhibitor DM0BTH8 RN Thioredoxin reductase inhibitors: a patent review.Expert Opin Ther Pat. 2017 May;27(5):547-556. DM0BTH8 RU https://www.ncbi.nlm.nih.gov/pubmed/27977313 DM31BMP DI DM31BMP DM31BMP DN Metal complex derivative 3 DM31BMP MI TTR7UJ3 DM31BMP MN Cytoplasmic thioredoxin reductase (TXNRD1) DM31BMP MT DTT DM31BMP MA Inhibitor DM31BMP RN Thioredoxin reductase inhibitors: a patent review.Expert Opin Ther Pat. 2017 May;27(5):547-556. DM31BMP RU https://www.ncbi.nlm.nih.gov/pubmed/27977313 DM9BYJ0 DI DM9BYJ0 DM9BYJ0 DN Methyl 2-amino-4-phenylthiophene-3-carboxylate DM9BYJ0 MI TTUWGRA DM9BYJ0 MN Protein kinase C zeta (PRKCZ) DM9BYJ0 MT DTT DM9BYJ0 MA Inhibitor DM9BYJ0 RN Compounds, formulations, and methods of protein kinase C inhibition. US8889672. DM9BYJ0 RU http://www.freepatentsonline.com/US8889672.html DMUNME2 DI DMUNME2 DMUNME2 DN Methylbenzenesulfonamide derivative 1 DMUNME2 MI TTOHFIY DMUNME2 MN Sphingosine kinase 1 (SPHK1) DMUNME2 MT DTT DMUNME2 MA Inhibitor DMUNME2 RN Sphingosine kinase inhibitors: a review of patent literature (2006-2015).Expert Opin Ther Pat. 2016 Dec;26(12):1409-1416. DMUNME2 RU https://www.ncbi.nlm.nih.gov/pubmed/27539678 DM5PS6K DI DM5PS6K DM5PS6K DN Methyl-piperidine compound 1 DM5PS6K MI TTYLQ8V DM5PS6K MN Prostaglandin E synthase (PTGES) DM5PS6K MT DTT DM5PS6K MA Inhibitor DM5PS6K RN Microsomal prostaglandin E2 synthase-1 inhibitors: a patent review.Expert Opin Ther Pat. 2017 Sep;27(9):1047-1059. DM5PS6K RU https://www.ncbi.nlm.nih.gov/pubmed/28627961 DMHVZ4M DI DMHVZ4M DMHVZ4M DN Methylsulfonylbenzamide derivative 2 DMHVZ4M MI TT4G2JS DMHVZ4M MN Voltage-gated sodium channel alpha Nav1.7 (SCN9A) DMHVZ4M MT DTT DMHVZ4M MA Inhibitor DMHVZ4M RN Sodium channel blockers: a patent review (2010 - 2014).Expert Opin Ther Pat. 2015 Mar;25(3):279-90. DMHVZ4M RU https://www.ncbi.nlm.nih.gov/pubmed/25539043 DM8UOY6 DI DM8UOY6 DM8UOY6 DN MHHFJYABEVJNEG-UHFFFAOYSA-N DM8UOY6 MI TTDYP7I DM8UOY6 MN Sphingosine-1-phosphate receptor 3 (S1PR3) DM8UOY6 MT DTT DM8UOY6 MA Inhibitor DM8UOY6 RN 6-amino-pyrimidine-4-carboxamide derivatives and related compounds which bind to the sphingosine 1-phosphate (S1P) receptor for the treatment of multiple sclerosis. US9150519. DM8UOY6 RU http://www.freepatentsonline.com/US9150519.html DMNEY58 DI DMNEY58 DMNEY58 DN ML272 DMNEY58 MI TT3T17P DMNEY58 MN Phospholipase D1 (PLD1) DMNEY58 MT DTT DMNEY58 MA Inhibitor DMNEY58 RN Antiviral therapies with phospholipase D inhibitors. US9453017. DMNEY58 RU http://www.freepatentsonline.com/US9453017.html DMRWNAY DI DMRWNAY DMRWNAY DN Monoamine derivative 1 DMRWNAY MI TTULVH8 DMRWNAY MN Tyrosinase (TYR) DMRWNAY MT DTT DMRWNAY MA Inhibitor DMRWNAY RN Tyrosinase inhibitors: a patent review (2011-2015).Expert Opin Ther Pat. 2016;26(3):347-62. DMRWNAY RU https://www.ncbi.nlm.nih.gov/pubmed/26815044 DMAZ6DI DI DMAZ6DI DMAZ6DI DN Monoamine derivative 2 DMAZ6DI MI TTULVH8 DMAZ6DI MN Tyrosinase (TYR) DMAZ6DI MT DTT DMAZ6DI MA Inhibitor DMAZ6DI RN Tyrosinase inhibitors: a patent review (2011-2015).Expert Opin Ther Pat. 2016;26(3):347-62. DMAZ6DI RU https://www.ncbi.nlm.nih.gov/pubmed/26815044 DM4I75L DI DM4I75L DM4I75L DN Monoamine derivative 3 DM4I75L MI TTULVH8 DM4I75L MN Tyrosinase (TYR) DM4I75L MT DTT DM4I75L MA Inhibitor DM4I75L RN Tyrosinase inhibitors: a patent review (2011-2015).Expert Opin Ther Pat. 2016;26(3):347-62. DM4I75L RU https://www.ncbi.nlm.nih.gov/pubmed/26815044 DMYFKP2 DI DMYFKP2 DMYFKP2 DN Monoamine derivative 4 DMYFKP2 MI TTULVH8 DMYFKP2 MN Tyrosinase (TYR) DMYFKP2 MT DTT DMYFKP2 MA Inhibitor DMYFKP2 RN Tyrosinase inhibitors: a patent review (2011-2015).Expert Opin Ther Pat. 2016;26(3):347-62. DMYFKP2 RU https://www.ncbi.nlm.nih.gov/pubmed/26815044 DM3PF60 DI DM3PF60 DM3PF60 DN Monoamine derivative 5 DM3PF60 MI TTULVH8 DM3PF60 MN Tyrosinase (TYR) DM3PF60 MT DTT DM3PF60 MA Inhibitor DM3PF60 RN Tyrosinase inhibitors: a patent review (2011-2015).Expert Opin Ther Pat. 2016;26(3):347-62. DM3PF60 RU https://www.ncbi.nlm.nih.gov/pubmed/26815044 DMCI6YH DI DMCI6YH DMCI6YH DN Monoaryl-1,2-diamine derivative 1 DMCI6YH MI TTZJYKH DMCI6YH MN Indoleamine 2,3-dioxygenase 1 (IDO1) DMCI6YH MT DTT DMCI6YH MA Inhibitor DMCI6YH RN A patent review of IDO1 inhibitors for cancer.Expert Opin Ther Pat. 2018 Apr;28(4):317-330. DMCI6YH RU https://www.ncbi.nlm.nih.gov/pubmed/29473428 DMXUNZ1 DI DMXUNZ1 DMXUNZ1 DN Monoaryl-1,2-diamine derivative 2 DMXUNZ1 MI TTZJYKH DMXUNZ1 MN Indoleamine 2,3-dioxygenase 1 (IDO1) DMXUNZ1 MT DTT DMXUNZ1 MA Inhibitor DMXUNZ1 RN A patent review of IDO1 inhibitors for cancer.Expert Opin Ther Pat. 2018 Apr;28(4):317-330. DMXUNZ1 RU https://www.ncbi.nlm.nih.gov/pubmed/29473428 DMAXKPC DI DMAXKPC DMAXKPC DN Monoaryl-1,2-diamine derivative 3 DMAXKPC MI TTZJYKH DMAXKPC MN Indoleamine 2,3-dioxygenase 1 (IDO1) DMAXKPC MT DTT DMAXKPC MA Modulator DMAXKPC RN A patent review of IDO1 inhibitors for cancer.Expert Opin Ther Pat. 2018 Apr;28(4):317-330. DMAXKPC RU https://www.ncbi.nlm.nih.gov/pubmed/29473428 DMD8AKH DI DMD8AKH DMD8AKH DN Monoaryl-1,2-diamine derivative 4 DMD8AKH MI TTZJYKH DMD8AKH MN Indoleamine 2,3-dioxygenase 1 (IDO1) DMD8AKH MT DTT DMD8AKH MA Modulator DMD8AKH RN A patent review of IDO1 inhibitors for cancer.Expert Opin Ther Pat. 2018 Apr;28(4):317-330. DMD8AKH RU https://www.ncbi.nlm.nih.gov/pubmed/29473428 DMJ8YZK DI DMJ8YZK DMJ8YZK DN Monofluorine derivative 1 DMJ8YZK MI TTZJYKH DMJ8YZK MN Indoleamine 2,3-dioxygenase 1 (IDO1) DMJ8YZK MT DTT DMJ8YZK MA Antagonist DMJ8YZK RN A patent review of IDO1 inhibitors for cancer.Expert Opin Ther Pat. 2018 Apr;28(4):317-330. DMJ8YZK RU https://www.ncbi.nlm.nih.gov/pubmed/29473428 DMNGQ3I DI DMNGQ3I DMNGQ3I DN MRL20 DMNGQ3I MI TTZMAO3 DMNGQ3I MN Peroxisome proliferator-activated receptor gamma (PPAR-gamma) DMNGQ3I MT DTT DMNGQ3I MA Agonist DMNGQ3I RN PPAR ligands and their therapeutic applications: a patent review (2008 - 2014).Expert Opin Ther Pat. 2015 Feb;25(2):175-91. DMNGQ3I RU https://www.ncbi.nlm.nih.gov/pubmed/25416646 DM8NS7U DI DM8NS7U DM8NS7U DN MRL24 DM8NS7U MI TTZMAO3 DM8NS7U MN Peroxisome proliferator-activated receptor gamma (PPAR-gamma) DM8NS7U MT DTT DM8NS7U MA Agonist DM8NS7U RN PPAR ligands and their therapeutic applications: a patent review (2008 - 2014).Expert Opin Ther Pat. 2015 Feb;25(2):175-91. DM8NS7U RU https://www.ncbi.nlm.nih.gov/pubmed/25416646 DMOZTUE DI DMOZTUE DMOZTUE DN Mycophenolic acid/nucleotide derivative 1 DMOZTUE MI TTL7C8Q DMOZTUE MN Inosine-5'-monophosphate dehydrogenase 1 (IMPDH1) DMOZTUE MT DTT DMOZTUE MA Inhibitor DMOZTUE RN Inosine-5'-monophosphate dehydrogenase (IMPDH) inhibitors: a patent and scientific literature review (2002-2016).Expert Opin Ther Pat. 2017 Jun;27(6):677-690. DMOZTUE RU https://www.ncbi.nlm.nih.gov/pubmed/28074661 DMHD8RK DI DMHD8RK DMHD8RK DN Mycophenolic acid/nucleotide derivative 10 DMHD8RK MI TTL7C8Q DMHD8RK MN Inosine-5'-monophosphate dehydrogenase 1 (IMPDH1) DMHD8RK MT DTT DMHD8RK MA Inhibitor DMHD8RK RN Inosine-5'-monophosphate dehydrogenase (IMPDH) inhibitors: a patent and scientific literature review (2002-2016).Expert Opin Ther Pat. 2017 Jun;27(6):677-690. DMHD8RK RU https://www.ncbi.nlm.nih.gov/pubmed/28074661 DMXWOAG DI DMXWOAG DMXWOAG DN Mycophenolic acid/nucleotide derivative 11 DMXWOAG MI TTL7C8Q DMXWOAG MN Inosine-5'-monophosphate dehydrogenase 1 (IMPDH1) DMXWOAG MT DTT DMXWOAG MA Inhibitor DMXWOAG RN Inosine-5'-monophosphate dehydrogenase (IMPDH) inhibitors: a patent and scientific literature review (2002-2016).Expert Opin Ther Pat. 2017 Jun;27(6):677-690. DMXWOAG RU https://www.ncbi.nlm.nih.gov/pubmed/28074661 DM47L9Q DI DM47L9Q DM47L9Q DN Mycophenolic acid/nucleotide derivative 12 DM47L9Q MI TTL7C8Q DM47L9Q MN Inosine-5'-monophosphate dehydrogenase 1 (IMPDH1) DM47L9Q MT DTT DM47L9Q MA Inhibitor DM47L9Q RN Inosine-5'-monophosphate dehydrogenase (IMPDH) inhibitors: a patent and scientific literature review (2002-2016).Expert Opin Ther Pat. 2017 Jun;27(6):677-690. DM47L9Q RU https://www.ncbi.nlm.nih.gov/pubmed/28074661 DMAT9NE DI DMAT9NE DMAT9NE DN Mycophenolic acid/nucleotide derivative 2 DMAT9NE MI TTL7C8Q DMAT9NE MN Inosine-5'-monophosphate dehydrogenase 1 (IMPDH1) DMAT9NE MT DTT DMAT9NE MA Inhibitor DMAT9NE RN Inosine-5'-monophosphate dehydrogenase (IMPDH) inhibitors: a patent and scientific literature review (2002-2016).Expert Opin Ther Pat. 2017 Jun;27(6):677-690. DMAT9NE RU https://www.ncbi.nlm.nih.gov/pubmed/28074661 DM5UX7B DI DM5UX7B DM5UX7B DN Mycophenolic acid/nucleotide derivative 3 DM5UX7B MI TTL7C8Q DM5UX7B MN Inosine-5'-monophosphate dehydrogenase 1 (IMPDH1) DM5UX7B MT DTT DM5UX7B MA Inhibitor DM5UX7B RN Inosine-5'-monophosphate dehydrogenase (IMPDH) inhibitors: a patent and scientific literature review (2002-2016).Expert Opin Ther Pat. 2017 Jun;27(6):677-690. DM5UX7B RU https://www.ncbi.nlm.nih.gov/pubmed/28074661 DMEHMKY DI DMEHMKY DMEHMKY DN Mycophenolic acid/nucleotide derivative 4 DMEHMKY MI TTL7C8Q DMEHMKY MN Inosine-5'-monophosphate dehydrogenase 1 (IMPDH1) DMEHMKY MT DTT DMEHMKY MA Inhibitor DMEHMKY RN Inosine-5'-monophosphate dehydrogenase (IMPDH) inhibitors: a patent and scientific literature review (2002-2016).Expert Opin Ther Pat. 2017 Jun;27(6):677-690. DMEHMKY RU https://www.ncbi.nlm.nih.gov/pubmed/28074661 DM74UP5 DI DM74UP5 DM74UP5 DN Mycophenolic acid/nucleotide derivative 5 DM74UP5 MI TTL7C8Q DM74UP5 MN Inosine-5'-monophosphate dehydrogenase 1 (IMPDH1) DM74UP5 MT DTT DM74UP5 MA Inhibitor DM74UP5 RN Inosine-5'-monophosphate dehydrogenase (IMPDH) inhibitors: a patent and scientific literature review (2002-2016).Expert Opin Ther Pat. 2017 Jun;27(6):677-690. DM74UP5 RU https://www.ncbi.nlm.nih.gov/pubmed/28074661 DMGFORB DI DMGFORB DMGFORB DN Mycophenolic acid/nucleotide derivative 6 DMGFORB MI TTL7C8Q DMGFORB MN Inosine-5'-monophosphate dehydrogenase 1 (IMPDH1) DMGFORB MT DTT DMGFORB MA Inhibitor DMGFORB RN Inosine-5'-monophosphate dehydrogenase (IMPDH) inhibitors: a patent and scientific literature review (2002-2016).Expert Opin Ther Pat. 2017 Jun;27(6):677-690. DMGFORB RU https://www.ncbi.nlm.nih.gov/pubmed/28074661 DMC27TO DI DMC27TO DMC27TO DN Mycophenolic acid/nucleotide derivative 7 DMC27TO MI TTL7C8Q DMC27TO MN Inosine-5'-monophosphate dehydrogenase 1 (IMPDH1) DMC27TO MT DTT DMC27TO MA Inhibitor DMC27TO RN Inosine-5'-monophosphate dehydrogenase (IMPDH) inhibitors: a patent and scientific literature review (2002-2016).Expert Opin Ther Pat. 2017 Jun;27(6):677-690. DMC27TO RU https://www.ncbi.nlm.nih.gov/pubmed/28074661 DMWGIJS DI DMWGIJS DMWGIJS DN Mycophenolic acid/nucleotide derivative 8 DMWGIJS MI TTL7C8Q DMWGIJS MN Inosine-5'-monophosphate dehydrogenase 1 (IMPDH1) DMWGIJS MT DTT DMWGIJS MA Inhibitor DMWGIJS RN Inosine-5'-monophosphate dehydrogenase (IMPDH) inhibitors: a patent and scientific literature review (2002-2016).Expert Opin Ther Pat. 2017 Jun;27(6):677-690. DMWGIJS RU https://www.ncbi.nlm.nih.gov/pubmed/28074661 DMYQTLK DI DMYQTLK DMYQTLK DN Mycophenolic acid/nucleotide derivative 9 DMYQTLK MI TTL7C8Q DMYQTLK MN Inosine-5'-monophosphate dehydrogenase 1 (IMPDH1) DMYQTLK MT DTT DMYQTLK MA Inhibitor DMYQTLK RN Inosine-5'-monophosphate dehydrogenase (IMPDH) inhibitors: a patent and scientific literature review (2002-2016).Expert Opin Ther Pat. 2017 Jun;27(6):677-690. DMYQTLK RU https://www.ncbi.nlm.nih.gov/pubmed/28074661 DMA8BLZ DI DMA8BLZ DMA8BLZ DN MyriberineA DMA8BLZ MI TT3WG5C DMA8BLZ MN Monoamine oxidase type A (MAO-A) DMA8BLZ MT DTT DMA8BLZ MA Inhibitor DMA8BLZ RN Novel monoamine oxidase inhibitors: a patent review (2012 - 2014).Expert Opin Ther Pat. 2015 Jan;25(1):91-110. DMA8BLZ RU https://www.ncbi.nlm.nih.gov/pubmed/25399762 DMH7T8C DI DMH7T8C DMH7T8C DN N-(2-phenylcyclopropyl) amino acid derivative 1 DMH7T8C MI TTZHPB8 DMH7T8C MN Lysine-specific demethylase 4A (KDM4A) DMH7T8C MT DTT DMH7T8C MA Inhibitor DMH7T8C RN LSD1 inhibitors: a patent review (2010-2015).Expert Opin Ther Pat. 2016 May;26(5):565-80. DMH7T8C RU https://www.ncbi.nlm.nih.gov/pubmed/27019002 DMH7T8C DI DMH7T8C DMH7T8C DN N-(2-phenylcyclopropyl) amino acid derivative 1 DMH7T8C MI TTNR0UQ DMH7T8C MN Lysine-specific histone demethylase 1 (LSD) DMH7T8C MT DTT DMH7T8C MA Inhibitor DMH7T8C RN LSD1 inhibitors: a patent review (2010-2015).Expert Opin Ther Pat. 2016 May;26(5):565-80. DMH7T8C RU https://www.ncbi.nlm.nih.gov/pubmed/27019002 DMH7T8C DI DMH7T8C DMH7T8C DN N-(2-phenylcyclopropyl) amino acid derivative 1 DMH7T8C MI TTGP7BY DMH7T8C MN Monoamine oxidase type B (MAO-B) DMH7T8C MT DTT DMH7T8C MA Inhibitor DMH7T8C RN LSD1 inhibitors: a patent review (2010-2015).Expert Opin Ther Pat. 2016 May;26(5):565-80. DMH7T8C RU https://www.ncbi.nlm.nih.gov/pubmed/27019002 DM6YV3O DI DM6YV3O DM6YV3O DN N-(2-phenylcyclopropyl) amino acid derivative 2 DM6YV3O MI TTNR0UQ DM6YV3O MN Lysine-specific histone demethylase 1 (LSD) DM6YV3O MT DTT DM6YV3O MA Inhibitor DM6YV3O RN LSD1 inhibitors: a patent review (2010-2015).Expert Opin Ther Pat. 2016 May;26(5):565-80. DM6YV3O RU https://www.ncbi.nlm.nih.gov/pubmed/27019002 DM6YV3O DI DM6YV3O DM6YV3O DN N-(2-phenylcyclopropyl) amino acid derivative 2 DM6YV3O MI TT32XQJ DM6YV3O MN Monoamine oxidase (MAO) DM6YV3O MT DTT DM6YV3O MA Inhibitor DM6YV3O RN LSD1 inhibitors: a patent review (2010-2015).Expert Opin Ther Pat. 2016 May;26(5):565-80. DM6YV3O RU https://www.ncbi.nlm.nih.gov/pubmed/27019002 DMFBRSL DI DMFBRSL DMFBRSL DN N-(2-phenylcyclopropyl) amino acid derivative 3 DMFBRSL MI TTNR0UQ DMFBRSL MN Lysine-specific histone demethylase 1 (LSD) DMFBRSL MT DTT DMFBRSL MA Inhibitor DMFBRSL RN LSD1 inhibitors: a patent review (2010-2015).Expert Opin Ther Pat. 2016 May;26(5):565-80. DMFBRSL RU https://www.ncbi.nlm.nih.gov/pubmed/27019002 DMFBRSL DI DMFBRSL DMFBRSL DN N-(2-phenylcyclopropyl) amino acid derivative 3 DMFBRSL MI TT3WG5C DMFBRSL MN Monoamine oxidase type A (MAO-A) DMFBRSL MT DTT DMFBRSL MA Inhibitor DMFBRSL RN LSD1 inhibitors: a patent review (2010-2015).Expert Opin Ther Pat. 2016 May;26(5):565-80. DMFBRSL RU https://www.ncbi.nlm.nih.gov/pubmed/27019002 DMFBRSL DI DMFBRSL DMFBRSL DN N-(2-phenylcyclopropyl) amino acid derivative 3 DMFBRSL MI TTGP7BY DMFBRSL MN Monoamine oxidase type B (MAO-B) DMFBRSL MT DTT DMFBRSL MA Inhibitor DMFBRSL RN LSD1 inhibitors: a patent review (2010-2015).Expert Opin Ther Pat. 2016 May;26(5):565-80. DMFBRSL RU https://www.ncbi.nlm.nih.gov/pubmed/27019002 DM6TYM0 DI DM6TYM0 DM6TYM0 DN N-(arylalkyl)-1H-indole-2-sulfonic acid amide derivative 1 DM6TYM0 MI TT6OEDT DM6TYM0 MN Cannabinoid receptor 1 (CB1) DM6TYM0 MT DTT DM6TYM0 MA Antagonist DM6TYM0 RN A comprehensive patents review on cannabinoid 1 receptor antagonists as antiobesity agents. Expert Opin Ther Pat. 2015 Oct;25(10):1093-116. DM6TYM0 RU https://pubmed.ncbi.nlm.nih.gov/26161824 DM2MPN0 DI DM2MPN0 DM2MPN0 DN N-(arylalkyl)-1H-indole-2-sulfonic acid amide derivative 2 DM2MPN0 MI TT6OEDT DM2MPN0 MN Cannabinoid receptor 1 (CB1) DM2MPN0 MT DTT DM2MPN0 MA Antagonist DM2MPN0 RN A comprehensive patents review on cannabinoid 1 receptor antagonists as antiobesity agents. Expert Opin Ther Pat. 2015 Oct;25(10):1093-116. DM2MPN0 RU https://pubmed.ncbi.nlm.nih.gov/26161824 DM8GJA7 DI DM8GJA7 DM8GJA7 DN N-(arylamino)sulfonamide derivative 1 DM8GJA7 MI TTZCRP3 DM8GJA7 MN ERK activator kinase (MEK) DM8GJA7 MT DTT DM8GJA7 MA Inhibitor DM8GJA7 RN MEK inhibitors in oncology: a patent review (2015-Present).Expert Opin Ther Pat. 2017 Aug;27(8):887-906. DM8GJA7 RU https://www.ncbi.nlm.nih.gov/pubmed/28594589 DMGQWKH DI DMGQWKH DMGQWKH DN N-(benzimidazole/indole) benzoic acid derivative 1 DMGQWKH MI TT5ZWB6 DMGQWKH MN Dihydrodiol dehydrogenase type I (AKR1C3) DMGQWKH MT DTT DMGQWKH MA Inhibitor DMGQWKH RN Aldo-Keto Reductase (AKR) 1C3 inhibitors: a patent review.Expert Opin Ther Pat. 2017 Dec;27(12):1329-1340. DMGQWKH RU https://www.ncbi.nlm.nih.gov/pubmed/28895472 DMOPUFM DI DMOPUFM DMOPUFM DN N-(benzimidazole/indole) benzoic acid derivative 2 DMOPUFM MI TT5ZWB6 DMOPUFM MN Dihydrodiol dehydrogenase type I (AKR1C3) DMOPUFM MT DTT DMOPUFM MA Inhibitor DMOPUFM RN Aldo-Keto Reductase (AKR) 1C3 inhibitors: a patent review.Expert Opin Ther Pat. 2017 Dec;27(12):1329-1340. DMOPUFM RU https://www.ncbi.nlm.nih.gov/pubmed/28895472 DM541QW DI DM541QW DM541QW DN N-(benzimidazolylcarbonyl)-piperidine derivative 1 DM541QW MI TT5ZWB6 DM541QW MN Dihydrodiol dehydrogenase type I (AKR1C3) DM541QW MT DTT DM541QW MA Inhibitor DM541QW RN Aldo-Keto Reductase (AKR) 1C3 inhibitors: a patent review.Expert Opin Ther Pat. 2017 Dec;27(12):1329-1340. DM541QW RU https://www.ncbi.nlm.nih.gov/pubmed/28895472 DM0OMAL DI DM0OMAL DM0OMAL DN N-(cyanomethyl)-4-(2-(phenylamino)pyrimidin-4-yl)benzamide derivative 1 DM0OMAL MI TT6DM01 DM0OMAL MN Janus kinase 1 (JAK-1) DM0OMAL MT DTT DM0OMAL MA Inhibitor DM0OMAL RN Inhibitors of JAK-family kinases: an update on the patent literature 2013-2015, part 1.Expert Opin Ther Pat. 2017 Feb;27(2):127-143. DM0OMAL RU https://www.ncbi.nlm.nih.gov/pubmed/27774824 DM0OMAL DI DM0OMAL DM0OMAL DN N-(cyanomethyl)-4-(2-(phenylamino)pyrimidin-4-yl)benzamide derivative 1 DM0OMAL MI TTRMX3V DM0OMAL MN Janus kinase 2 (JAK-2) DM0OMAL MT DTT DM0OMAL MA Inhibitor DM0OMAL RN Inhibitors of JAK-family kinases: an update on the patent literature 2013-2015, part 1.Expert Opin Ther Pat. 2017 Feb;27(2):127-143. DM0OMAL RU https://www.ncbi.nlm.nih.gov/pubmed/27774824 DM0OMAL DI DM0OMAL DM0OMAL DN N-(cyanomethyl)-4-(2-(phenylamino)pyrimidin-4-yl)benzamide derivative 1 DM0OMAL MI TTT7PJU DM0OMAL MN Janus kinase 3 (JAK-3) DM0OMAL MT DTT DM0OMAL MA Inhibitor DM0OMAL RN Inhibitors of JAK-family kinases: an update on the patent literature 2013-2015, part 1.Expert Opin Ther Pat. 2017 Feb;27(2):127-143. DM0OMAL RU https://www.ncbi.nlm.nih.gov/pubmed/27774824 DMARHJ9 DI DMARHJ9 DMARHJ9 DN N-(indolylcarbonyl)-piperidine derivative 1 DMARHJ9 MI TT5ZWB6 DMARHJ9 MN Dihydrodiol dehydrogenase type I (AKR1C3) DMARHJ9 MT DTT DMARHJ9 MA Inhibitor DMARHJ9 RN Aldo-Keto Reductase (AKR) 1C3 inhibitors: a patent review.Expert Opin Ther Pat. 2017 Dec;27(12):1329-1340. DMARHJ9 RU https://www.ncbi.nlm.nih.gov/pubmed/28895472 DM310ES DI DM310ES DM310ES DN N-(naphthylamino)-benzoate derivative 1 DM310ES MI TT5ZWB6 DM310ES MN Dihydrodiol dehydrogenase type I (AKR1C3) DM310ES MT DTT DM310ES MA Inhibitor; Antagonist; Blocker DM310ES RN Aldo-Keto Reductase (AKR) 1C3 inhibitors: a patent review.Expert Opin Ther Pat. 2017 Dec;27(12):1329-1340. DM310ES RU https://www.ncbi.nlm.nih.gov/pubmed/28895472 DMNIWVG DI DMNIWVG DMNIWVG DN N-(phenylamino)-benzoate derivative 1 DMNIWVG MI TT5ZWB6 DMNIWVG MN Dihydrodiol dehydrogenase type I (AKR1C3) DMNIWVG MT DTT DMNIWVG MA Inhibitor; Antagonist; Blocker DMNIWVG RN Aldo-Keto Reductase (AKR) 1C3 inhibitors: a patent review.Expert Opin Ther Pat. 2017 Dec;27(12):1329-1340. DMNIWVG RU https://www.ncbi.nlm.nih.gov/pubmed/28895472 DM0ZJX7 DI DM0ZJX7 DM0ZJX7 DN N-(phenylpyrazolyl)benzamide derivative 1 DM0ZJX7 MI TTTDVOJ DM0ZJX7 MN Tropomyosin-related kinase A (TrkA) DM0ZJX7 MT DTT DM0ZJX7 MA Inhibitor DM0ZJX7 RN Tropomyosin receptor kinase inhibitors: an updated patent review for 2010-2016 - Part II.Expert Opin Ther Pat. 2017 Jul;27(7):831-849. DM0ZJX7 RU https://www.ncbi.nlm.nih.gov/pubmed/28270021 DM305UL DI DM305UL DM305UL DN N-(pyridin-2-yl)pyridine methylsulfone derivative 1 DM305UL MI TT7HF4W DM305UL MN Cyclin-dependent kinase 2 (CDK2) DM305UL MT DTT DM305UL MA Inhibitor DM305UL RN Cyclin-dependent kinase inhibitors for cancer therapy: a patent review (2009 - 2014).Expert Opin Ther Pat. 2015;25(9):953-70. DM305UL RU https://www.ncbi.nlm.nih.gov/pubmed/26161698 DM305UL DI DM305UL DM305UL DN N-(pyridin-2-yl)pyridine methylsulfone derivative 1 DM305UL MI TT1LVF2 DM305UL MN Cyclin-dependent kinase 9 (CDK9) DM305UL MT DTT DM305UL MA Inhibitor DM305UL RN Cyclin-dependent kinase inhibitors for cancer therapy: a patent review (2009 - 2014).Expert Opin Ther Pat. 2015;25(9):953-70. DM305UL RU https://www.ncbi.nlm.nih.gov/pubmed/26161698 DMRE2I3 DI DMRE2I3 DMRE2I3 DN N-(pyridin-2-yl)pyrimidin-4-amine derivative 1 DMRE2I3 MI TT1LVF2 DMRE2I3 MN Cyclin-dependent kinase 9 (CDK9) DMRE2I3 MT DTT DMRE2I3 MA Inhibitor DMRE2I3 RN Cyclin-dependent kinase inhibitors for cancer therapy: a patent review (2009 - 2014).Expert Opin Ther Pat. 2015;25(9):953-70. DMRE2I3 RU https://www.ncbi.nlm.nih.gov/pubmed/26161698 DMTZ6K9 DI DMTZ6K9 DMTZ6K9 DN N-(pyridin-2-yl)pyrimidin-4-amine derivative 2 DMTZ6K9 MI TT7HF4W DMTZ6K9 MN Cyclin-dependent kinase 2 (CDK2) DMTZ6K9 MT DTT DMTZ6K9 MA Inhibitor DMTZ6K9 RN Cyclin-dependent kinase inhibitors for cancer therapy: a patent review (2009 - 2014).Expert Opin Ther Pat. 2015;25(9):953-70. DMTZ6K9 RU https://www.ncbi.nlm.nih.gov/pubmed/26161698 DMTZ6K9 DI DMTZ6K9 DMTZ6K9 DN N-(pyridin-2-yl)pyrimidin-4-amine derivative 2 DMTZ6K9 MI TT1LVF2 DMTZ6K9 MN Cyclin-dependent kinase 9 (CDK9) DMTZ6K9 MT DTT DMTZ6K9 MA Inhibitor DMTZ6K9 RN Cyclin-dependent kinase inhibitors for cancer therapy: a patent review (2009 - 2014).Expert Opin Ther Pat. 2015;25(9):953-70. DMTZ6K9 RU https://www.ncbi.nlm.nih.gov/pubmed/26161698 DMA85UD DI DMA85UD DMA85UD DN N-(pyridinepyrroylylcarbonyl)-piperidine derivative 1 DMA85UD MI TT5ZWB6 DMA85UD MN Dihydrodiol dehydrogenase type I (AKR1C3) DMA85UD MT DTT DMA85UD MA Inhibitor DMA85UD RN Aldo-Keto Reductase (AKR) 1C3 inhibitors: a patent review.Expert Opin Ther Pat. 2017 Dec;27(12):1329-1340. DMA85UD RU https://www.ncbi.nlm.nih.gov/pubmed/28895472 DMSD4G0 DI DMSD4G0 DMSD4G0 DN N,N-bis(5-pyrazoyl)urea derivative 1 DMSD4G0 MI TTTDVOJ DMSD4G0 MN Tropomyosin-related kinase A (TrkA) DMSD4G0 MT DTT DMSD4G0 MA Inhibitor DMSD4G0 RN Tropomyosin receptor kinase inhibitors: an updated patent review for 2010-2016 - Part I.Expert Opin Ther Pat. 2017 Jun;27(6):733-751. DMSD4G0 RU https://www.ncbi.nlm.nih.gov/pubmed/28270010 DMEXPAU DI DMEXPAU DMEXPAU DN N,N-methylenebis-2-phenylacetamide and benzenesulfonamide derivative 1 DMEXPAU MI TTMSFAW DMEXPAU MN Cannabinoid receptor 2 (CB2) DMEXPAU MT DTT DMEXPAU RN Cannabinoid receptor 2 (CB2) agonists and antagonists: a patent update.Expert Opin Ther Pat. 2016 Jul;26(7):843-56. DMEXPAU RU https://www.ncbi.nlm.nih.gov/pubmed/27215781 DMD4CU5 DI DMD4CU5 DMD4CU5 DN N,N-methylenebis-2-phenylacetamide and benzenesulfonamide derivative 2 DMD4CU5 MI TT6OEDT DMD4CU5 MN Cannabinoid receptor 1 (CB1) DMD4CU5 MT DTT DMD4CU5 RN Cannabinoid receptor 2 (CB2) agonists and antagonists: a patent update.Expert Opin Ther Pat. 2016 Jul;26(7):843-56. DMD4CU5 RU https://www.ncbi.nlm.nih.gov/pubmed/27215781 DMD4CU5 DI DMD4CU5 DMD4CU5 DN N,N-methylenebis-2-phenylacetamide and benzenesulfonamide derivative 2 DMD4CU5 MI TTMSFAW DMD4CU5 MN Cannabinoid receptor 2 (CB2) DMD4CU5 MT DTT DMD4CU5 RN Cannabinoid receptor 2 (CB2) agonists and antagonists: a patent update.Expert Opin Ther Pat. 2016 Jul;26(7):843-56. DMD4CU5 RU https://www.ncbi.nlm.nih.gov/pubmed/27215781 DMM78VS DI DMM78VS DMM78VS DN N,N-methylenebis-2-phenylacetamide and benzenesulfonamide derivative 3 DMM78VS MI TT6OEDT DMM78VS MN Cannabinoid receptor 1 (CB1) DMM78VS MT DTT DMM78VS RN Cannabinoid receptor 2 (CB2) agonists and antagonists: a patent update.Expert Opin Ther Pat. 2016 Jul;26(7):843-56. DMM78VS RU https://www.ncbi.nlm.nih.gov/pubmed/27215781 DMM78VS DI DMM78VS DMM78VS DN N,N-methylenebis-2-phenylacetamide and benzenesulfonamide derivative 3 DMM78VS MI TTMSFAW DMM78VS MN Cannabinoid receptor 2 (CB2) DMM78VS MT DTT DMM78VS RN Cannabinoid receptor 2 (CB2) agonists and antagonists: a patent update.Expert Opin Ther Pat. 2016 Jul;26(7):843-56. DMM78VS RU https://www.ncbi.nlm.nih.gov/pubmed/27215781 DM6R34M DI DM6R34M DM6R34M DN N-{4 DM6R34M MI TTCGOIN DM6R34M MN PIM-3 protein kinase (PIM3) DM6R34M MT DTT DM6R34M MA Inhibitor DM6R34M RN Kinase inhibitors and methods of their use. US8592455. DM6R34M RU http://www.freepatentsonline.com/US8592455.html DMRHVWA DI DMRHVWA DMRHVWA DN N6-cyclopropyllydine derivative 1 DMRHVWA MI TTNR0UQ DMRHVWA MN Lysine-specific histone demethylase 1 (LSD) DMRHVWA MT DTT DMRHVWA MA Inhibitor DMRHVWA RN LSD1 inhibitors: a patent review (2010-2015).Expert Opin Ther Pat. 2016 May;26(5):565-80. DMRHVWA RU https://www.ncbi.nlm.nih.gov/pubmed/27019002 DM5GCUR DI DM5GCUR DM5GCUR DN N-acylpiperidine ether derivative 1 DM5GCUR MI TTTDVOJ DM5GCUR MN Tropomyosin-related kinase A (TrkA) DM5GCUR MT DTT DM5GCUR MA Inhibitor DM5GCUR RN Tropomyosin receptor kinase inhibitors: an updated patent review for 2010-2016 - Part II.Expert Opin Ther Pat. 2017 Jul;27(7):831-849. DM5GCUR RU https://www.ncbi.nlm.nih.gov/pubmed/28270021 DM02RQ4 DI DM02RQ4 DM02RQ4 DN N-acylpiperidine ether derivative 2 DM02RQ4 MI TTTDVOJ DM02RQ4 MN Tropomyosin-related kinase A (TrkA) DM02RQ4 MT DTT DM02RQ4 MA Inhibitor DM02RQ4 RN Tropomyosin receptor kinase inhibitors: an updated patent review for 2010-2016 - Part II.Expert Opin Ther Pat. 2017 Jul;27(7):831-849. DM02RQ4 RU https://www.ncbi.nlm.nih.gov/pubmed/28270021 DMXWE5R DI DMXWE5R DMXWE5R DN N-acylpiperidine ether derivative 3 DMXWE5R MI TTTDVOJ DMXWE5R MN Tropomyosin-related kinase A (TrkA) DMXWE5R MT DTT DMXWE5R MA Inhibitor DMXWE5R RN Tropomyosin receptor kinase inhibitors: an updated patent review for 2010-2016 - Part II.Expert Opin Ther Pat. 2017 Jul;27(7):831-849. DMXWE5R RU https://www.ncbi.nlm.nih.gov/pubmed/28270021 DMBUQDR DI DMBUQDR DMBUQDR DN N-acylpiperidine ether derivative 4 DMBUQDR MI TTTDVOJ DMBUQDR MN Tropomyosin-related kinase A (TrkA) DMBUQDR MT DTT DMBUQDR MA Inhibitor DMBUQDR RN Tropomyosin receptor kinase inhibitors: an updated patent review for 2010-2016 - Part II.Expert Opin Ther Pat. 2017 Jul;27(7):831-849. DMBUQDR RU https://www.ncbi.nlm.nih.gov/pubmed/28270021 DMQ2MKT DI DMQ2MKT DMQ2MKT DN N-acylpiperidine ether derivative 5 DMQ2MKT MI TTTDVOJ DMQ2MKT MN Tropomyosin-related kinase A (TrkA) DMQ2MKT MT DTT DMQ2MKT MA Inhibitor DMQ2MKT RN Tropomyosin receptor kinase inhibitors: an updated patent review for 2010-2016 - Part II.Expert Opin Ther Pat. 2017 Jul;27(7):831-849. DMQ2MKT RU https://www.ncbi.nlm.nih.gov/pubmed/28270021 DMAS01P DI DMAS01P DMAS01P DN N-acylpiperidine ether derivative 6 DMAS01P MI TTTDVOJ DMAS01P MN Tropomyosin-related kinase A (TrkA) DMAS01P MT DTT DMAS01P MA Inhibitor DMAS01P RN Tropomyosin receptor kinase inhibitors: an updated patent review for 2010-2016 - Part II.Expert Opin Ther Pat. 2017 Jul;27(7):831-849. DMAS01P RU https://www.ncbi.nlm.nih.gov/pubmed/28270021 DMCJR4N DI DMCJR4N DMCJR4N DN N-acylpiperidine ether derivative 7 DMCJR4N MI TTTDVOJ DMCJR4N MN Tropomyosin-related kinase A (TrkA) DMCJR4N MT DTT DMCJR4N MA Inhibitor DMCJR4N RN Tropomyosin receptor kinase inhibitors: an updated patent review for 2010-2016 - Part II.Expert Opin Ther Pat. 2017 Jul;27(7):831-849. DMCJR4N RU https://www.ncbi.nlm.nih.gov/pubmed/28270021 DMQ4ULC DI DMQ4ULC DMQ4ULC DN N-acylpyrrolidine ether derivative 1 DMQ4ULC MI TTTDVOJ DMQ4ULC MN Tropomyosin-related kinase A (TrkA) DMQ4ULC MT DTT DMQ4ULC MA Inhibitor DMQ4ULC RN Tropomyosin receptor kinase inhibitors: an updated patent review for 2010-2016 - Part II.Expert Opin Ther Pat. 2017 Jul;27(7):831-849. DMQ4ULC RU https://www.ncbi.nlm.nih.gov/pubmed/28270021 DMK4Y71 DI DMK4Y71 DMK4Y71 DN N-acylpyrrolidine ether derivative 2 DMK4Y71 MI TTTDVOJ DMK4Y71 MN Tropomyosin-related kinase A (TrkA) DMK4Y71 MT DTT DMK4Y71 MA Inhibitor DMK4Y71 RN Tropomyosin receptor kinase inhibitors: an updated patent review for 2010-2016 - Part II.Expert Opin Ther Pat. 2017 Jul;27(7):831-849. DMK4Y71 RU https://www.ncbi.nlm.nih.gov/pubmed/28270021 DMU2WGL DI DMU2WGL DMU2WGL DN N-alkyl-4-oxazolecar boxamide derivative 1 DMU2WGL MI TTDP1UC DMU2WGL MN Fatty acid amide hydrolase (FAAH) DMU2WGL MT DTT DMU2WGL MA Inhibitor DMU2WGL RN Fatty acid amide hydrolase inhibitors: a patent review (2009-2014).Expert Opin Ther Pat. 2015;25(11):1247-66. DMU2WGL RU https://www.ncbi.nlm.nih.gov/pubmed/26413912 DMR6YAD DI DMR6YAD DMR6YAD DN N-alkyl-4-oxazolecar boxamide derivative 2 DMR6YAD MI TTDP1UC DMR6YAD MN Fatty acid amide hydrolase (FAAH) DMR6YAD MT DTT DMR6YAD MA Inhibitor DMR6YAD RN Fatty acid amide hydrolase inhibitors: a patent review (2009-2014).Expert Opin Ther Pat. 2015;25(11):1247-66. DMR6YAD RU https://www.ncbi.nlm.nih.gov/pubmed/26413912 DMXPBL5 DI DMXPBL5 DMXPBL5 DN N-alkylamide derivative 1 DMXPBL5 MI TTHS256 DMXPBL5 MN Metabotropic glutamate receptor 5 (mGluR5) DMXPBL5 MT DTT DMXPBL5 MA Modulator DMXPBL5 RN mGlu5 negative allosteric modulators: a patent review (2013 - 2016).Expert Opin Ther Pat. 2017 Jun;27(6):691-706. DMXPBL5 RU https://www.ncbi.nlm.nih.gov/pubmed/28067079 DM568TX DI DM568TX DM568TX DN N-alkylamide derivative 2 DM568TX MI TTHS256 DM568TX MN Metabotropic glutamate receptor 5 (mGluR5) DM568TX MT DTT DM568TX MA Modulator DM568TX RN mGlu5 negative allosteric modulators: a patent review (2013 - 2016).Expert Opin Ther Pat. 2017 Jun;27(6):691-706. DM568TX RU https://www.ncbi.nlm.nih.gov/pubmed/28067079 DMWLPEB DI DMWLPEB DMWLPEB DN Naphthalene derivative 1 DMWLPEB MI TTGIZLN DMWLPEB MN Keap1-Nrf2[dual DLG and ETGE] PPI (KEAP1-Nrf2 DLG and ETGE) DMWLPEB MT DTT DMWLPEB MA Modulator DMWLPEB RN Recent progress in the development of small molecule Nrf2 modulators: a patent review (2012-2016).Expert Opin Ther Pat. 2017 Jul;27(7):763-785. DMWLPEB RU https://www.ncbi.nlm.nih.gov/pubmed/28454500 DMWLPEB DI DMWLPEB DMWLPEB DN Naphthalene derivative 1 DMWLPEB MI TTA6ZN2 DMWLPEB MN Nuclear factor erythroid 2-related factor 2 (Nrf2) DMWLPEB MT DTT DMWLPEB MA Inhibitor DMWLPEB RN Recent progress in the development of small molecule Nrf2 modulators: a patent review (2012-2016).Expert Opin Ther Pat. 2017 Jul;27(7):763-785. DMWLPEB RU https://www.ncbi.nlm.nih.gov/pubmed/28454500 DMTGIP7 DI DMTGIP7 DMTGIP7 DN Naphthyridine and isoquinoline derivative 1 DMTGIP7 MI TTH6V3D DMTGIP7 MN Cyclin-dependent kinase 1 (CDK1) DMTGIP7 MT DTT DMTGIP7 MA Inhibitor DMTGIP7 RN Cyclin-dependent kinase inhibitors for cancer therapy: a patent review (2009 - 2014).Expert Opin Ther Pat. 2015;25(9):953-70. DMTGIP7 RU https://www.ncbi.nlm.nih.gov/pubmed/26161698 DMTGIP7 DI DMTGIP7 DMTGIP7 DN Naphthyridine and isoquinoline derivative 1 DMTGIP7 MI TT7HF4W DMTGIP7 MN Cyclin-dependent kinase 2 (CDK2) DMTGIP7 MT DTT DMTGIP7 MA Inhibitor DMTGIP7 RN Cyclin-dependent kinase inhibitors for cancer therapy: a patent review (2009 - 2014).Expert Opin Ther Pat. 2015;25(9):953-70. DMTGIP7 RU https://www.ncbi.nlm.nih.gov/pubmed/26161698 DMTGIP7 DI DMTGIP7 DMTGIP7 DN Naphthyridine and isoquinoline derivative 1 DMTGIP7 MI TTL4Q97 DMTGIP7 MN Cyclin-dependent kinase 5 (CDK5) DMTGIP7 MT DTT DMTGIP7 MA Inhibitor DMTGIP7 RN Cyclin-dependent kinase inhibitors for cancer therapy: a patent review (2009 - 2014).Expert Opin Ther Pat. 2015;25(9):953-70. DMTGIP7 RU https://www.ncbi.nlm.nih.gov/pubmed/26161698 DMQHAU1 DI DMQHAU1 DMQHAU1 DN N-arylmethyl-N-phenyl cyclic urea derivative 1 DMQHAU1 MI TTTDVOJ DMQHAU1 MN Tropomyosin-related kinase A (TrkA) DMQHAU1 MT DTT DMQHAU1 MA Inhibitor DMQHAU1 RN Tropomyosin receptor kinase inhibitors: an updated patent review for 2010-2016 - Part I.Expert Opin Ther Pat. 2017 Jun;27(6):733-751. DMQHAU1 RU https://www.ncbi.nlm.nih.gov/pubmed/28270010 DMWVQDA DI DMWVQDA DMWVQDA DN N-arylmethyl-N-phenyl cyclic urea derivative 2 DMWVQDA MI TTTDVOJ DMWVQDA MN Tropomyosin-related kinase A (TrkA) DMWVQDA MT DTT DMWVQDA MA Inhibitor DMWVQDA RN Tropomyosin receptor kinase inhibitors: an updated patent review for 2010-2016 - Part I.Expert Opin Ther Pat. 2017 Jun;27(6):733-751. DMWVQDA RU https://www.ncbi.nlm.nih.gov/pubmed/28270010 DMEU12W DI DMEU12W DMEU12W DN NCGC00381656-01 DMEU12W MI TTIG67W DMEU12W MN Lysine-specific demethylase 5A (KDM5A) DMEU12W MT DTT DMEU12W MA Inhibitor DMEU12W RN Histone demethylase inhibitors. US9738637. DMEU12W RU http://www.freepatentsonline.com/US9738637.html DM6TMXL DI DM6TMXL DM6TMXL DN N-containing heterocyclic derivative 1 DM6TMXL MI TTJOW1I DM6TMXL MN Mannoside acetylglucosaminyltransferase 2 (MGAT2) DM6TMXL MT DTT DM6TMXL MA Inhibitor DM6TMXL RN Acyltransferase inhibitors: a patent review (2010-present).Expert Opin Ther Pat. 2015 Feb;25(2):145-58. DM6TMXL RU https://www.ncbi.nlm.nih.gov/pubmed/25470667 DMW1PL7 DI DMW1PL7 DMW1PL7 DN NG7 DMW1PL7 MI TTI1FPZ DMW1PL7 MN Epithelial discoidin domain receptor 1 (DDR1) DMW1PL7 MT DTT DMW1PL7 MA Inhibitor DMW1PL7 RN Fused 2-aminothiazole compounds. US8765747. DMW1PL7 RU http://www.freepatentsonline.com/US8765747.html DMW2LD5 DI DMW2LD5 DMW2LD5 DN Nicotinyl hydroxamic acid derivative 1 DMW2LD5 MI TTULVH8 DMW2LD5 MN Tyrosinase (TYR) DMW2LD5 MT DTT DMW2LD5 MA Inhibitor DMW2LD5 RN Tyrosinase inhibitors: a patent review (2011-2015).Expert Opin Ther Pat. 2016;26(3):347-62. DMW2LD5 RU https://www.ncbi.nlm.nih.gov/pubmed/26815044 DMXDSYU DI DMXDSYU DMXDSYU DN Nitrogen mustard derivative 1 DMXDSYU MI TT7HF4W DMXDSYU MN Cyclin-dependent kinase 2 (CDK2) DMXDSYU MT DTT DMXDSYU MA Inhibitor DMXDSYU RN Cyclin-dependent kinase inhibitors for cancer therapy: a patent review (2009 - 2014).Expert Opin Ther Pat. 2015;25(9):953-70. DMXDSYU RU https://www.ncbi.nlm.nih.gov/pubmed/26161698 DMXDSYU DI DMXDSYU DMXDSYU DN Nitrogen mustard derivative 1 DMXDSYU MI TTMYWL7 DMXDSYU MN Cyclin-dependent kinase 3 (CDK3) DMXDSYU MT DTT DMXDSYU MA Inhibitor DMXDSYU RN Cyclin-dependent kinase inhibitors for cancer therapy: a patent review (2009 - 2014).Expert Opin Ther Pat. 2015;25(9):953-70. DMXDSYU RU https://www.ncbi.nlm.nih.gov/pubmed/26161698 DMXDSYU DI DMXDSYU DMXDSYU DN Nitrogen mustard derivative 1 DMXDSYU MI TT1LVF2 DMXDSYU MN Cyclin-dependent kinase 9 (CDK9) DMXDSYU MT DTT DMXDSYU MA Inhibitor DMXDSYU RN Cyclin-dependent kinase inhibitors for cancer therapy: a patent review (2009 - 2014).Expert Opin Ther Pat. 2015;25(9):953-70. DMXDSYU RU https://www.ncbi.nlm.nih.gov/pubmed/26161698 DMD7OW0 DI DMD7OW0 DMD7OW0 DN Nitrogen/sulfur-substituted estrene derivative 1 DMD7OW0 MI TT5ZWB6 DMD7OW0 MN Dihydrodiol dehydrogenase type I (AKR1C3) DMD7OW0 MT DTT DMD7OW0 MA Inhibitor DMD7OW0 RN Aldo-Keto Reductase (AKR) 1C3 inhibitors: a patent review.Expert Opin Ther Pat. 2017 Dec;27(12):1329-1340. DMD7OW0 RU https://www.ncbi.nlm.nih.gov/pubmed/28895472 DMIVK7D DI DMIVK7D DMIVK7D DN N-methylmethanesulfonamide derivative 1 DMIVK7D MI TT6DM01 DMIVK7D MN Janus kinase 1 (JAK-1) DMIVK7D MT DTT DMIVK7D MA Inhibitor DMIVK7D RN Inhibitors of JAK-family kinases: an update on the patent literature 2013-2015, part 2.Expert Opin Ther Pat. 2017 Feb;27(2):145-161. DMIVK7D RU https://www.ncbi.nlm.nih.gov/pubmed/27774822 DMIVK7D DI DMIVK7D DMIVK7D DN N-methylmethanesulfonamide derivative 1 DMIVK7D MI TTT7PJU DMIVK7D MN Janus kinase 3 (JAK-3) DMIVK7D MT DTT DMIVK7D MA Inhibitor DMIVK7D RN Inhibitors of JAK-family kinases: an update on the patent literature 2013-2015, part 2.Expert Opin Ther Pat. 2017 Feb;27(2):145-161. DMIVK7D RU https://www.ncbi.nlm.nih.gov/pubmed/27774822 DMIVK7D DI DMIVK7D DMIVK7D DN N-methylmethanesulfonamide derivative 1 DMIVK7D MI TTBYWP2 DMIVK7D MN TYK2 tyrosine kinase (TYK2) DMIVK7D MT DTT DMIVK7D MA Inhibitor DMIVK7D RN Inhibitors of JAK-family kinases: an update on the patent literature 2013-2015, part 2.Expert Opin Ther Pat. 2017 Feb;27(2):145-161. DMIVK7D RU https://www.ncbi.nlm.nih.gov/pubmed/27774822 DMCVBPF DI DMCVBPF DMCVBPF DN N-naphtyl-N-benzylurea derivative 1 DMCVBPF MI TTRZQE3 DMCVBPF MN Glycogen synthase kinase-3 alpha (GSK-3A) DMCVBPF MT DTT DMCVBPF MA Inhibitor DMCVBPF RN Glycogen synthase kinase 3 (GSK-3) inhibitors: a patent update (2014-2015).Expert Opin Ther Pat. 2017 Jun;27(6):657-666. DMCVBPF RU https://www.ncbi.nlm.nih.gov/pubmed/27828716 DM2P509 DI DM2P509 DM2P509 DN N-oxalyl-D-tyrosine derivative 1 DM2P509 MI TTWAQBO DM2P509 MN Lysine-specific demethylase 4E (KDM4E) DM2P509 MT DTT DM2P509 MA Inhibitor DM2P509 RN KDM4 histone demethylase inhibitors for anti-cancer agents: a patent review.Expert Opin Ther Pat. 2015 Feb;25(2):135-44. DM2P509 RU https://www.ncbi.nlm.nih.gov/pubmed/25468267 DMWSZMC DI DMWSZMC DMWSZMC DN N-oxalyl-D-tyrosine derivative 2 DMWSZMC MI TTWAQBO DMWSZMC MN Lysine-specific demethylase 4E (KDM4E) DMWSZMC MT DTT DMWSZMC MA Inhibitor DMWSZMC RN KDM4 histone demethylase inhibitors for anti-cancer agents: a patent review.Expert Opin Ther Pat. 2015 Feb;25(2):135-44. DMWSZMC RU https://www.ncbi.nlm.nih.gov/pubmed/25468267 DM7XS9G DI DM7XS9G DM7XS9G DN N-oxalyl-D-tyrosine derivative 3 DM7XS9G MI TTWAQBO DM7XS9G MN Lysine-specific demethylase 4E (KDM4E) DM7XS9G MT DTT DM7XS9G MA Inhibitor DM7XS9G RN KDM4 histone demethylase inhibitors for anti-cancer agents: a patent review.Expert Opin Ther Pat. 2015 Feb;25(2):135-44. DM7XS9G RU https://www.ncbi.nlm.nih.gov/pubmed/25468267 DMUE7R5 DI DMUE7R5 DMUE7R5 DN N-oxalyl-D-tyrosine derivative 4 DMUE7R5 MI TTWAQBO DMUE7R5 MN Lysine-specific demethylase 4E (KDM4E) DMUE7R5 MT DTT DMUE7R5 MA Inhibitor DMUE7R5 RN KDM4 histone demethylase inhibitors for anti-cancer agents: a patent review.Expert Opin Ther Pat. 2015 Feb;25(2):135-44. DMUE7R5 RU https://www.ncbi.nlm.nih.gov/pubmed/25468267 DM673GR DI DM673GR DM673GR DN N-oxalyl-D-tyrosine derivative 5 DM673GR MI TTWAQBO DM673GR MN Lysine-specific demethylase 4E (KDM4E) DM673GR MT DTT DM673GR MA Inhibitor DM673GR RN KDM4 histone demethylase inhibitors for anti-cancer agents: a patent review.Expert Opin Ther Pat. 2015 Feb;25(2):135-44. DM673GR RU https://www.ncbi.nlm.nih.gov/pubmed/25468267 DM106SU DI DM106SU DM106SU DN N-oxalyl-D-tyrosine derivative 6 DM106SU MI TTWAQBO DM106SU MN Lysine-specific demethylase 4E (KDM4E) DM106SU MT DTT DM106SU MA Inhibitor DM106SU RN KDM4 histone demethylase inhibitors for anti-cancer agents: a patent review.Expert Opin Ther Pat. 2015 Feb;25(2):135-44. DM106SU RU https://www.ncbi.nlm.nih.gov/pubmed/25468267 DM13K8R DI DM13K8R DM13K8R DN N-oxalyl-D-tyrosine derivative 7 DM13K8R MI TTWAQBO DM13K8R MN Lysine-specific demethylase 4E (KDM4E) DM13K8R MT DTT DM13K8R MA Inhibitor DM13K8R RN KDM4 histone demethylase inhibitors for anti-cancer agents: a patent review.Expert Opin Ther Pat. 2015 Feb;25(2):135-44. DM13K8R RU https://www.ncbi.nlm.nih.gov/pubmed/25468267 DMNV0OA DI DMNV0OA DMNV0OA DN N-oxalyl-D-tyrosine derivative 8 DMNV0OA MI TTWAQBO DMNV0OA MN Lysine-specific demethylase 4E (KDM4E) DMNV0OA MT DTT DMNV0OA MA Inhibitor DMNV0OA RN KDM4 histone demethylase inhibitors for anti-cancer agents: a patent review.Expert Opin Ther Pat. 2015 Feb;25(2):135-44. DMNV0OA RU https://www.ncbi.nlm.nih.gov/pubmed/25468267 DMTMYJ6 DI DMTMYJ6 DMTMYJ6 DN N-oxalyl-D-tyrosine derivative 9 DMTMYJ6 MI TTWAQBO DMTMYJ6 MN Lysine-specific demethylase 4E (KDM4E) DMTMYJ6 MT DTT DMTMYJ6 MA Inhibitor DMTMYJ6 RN KDM4 histone demethylase inhibitors for anti-cancer agents: a patent review.Expert Opin Ther Pat. 2015 Feb;25(2):135-44. DMTMYJ6 RU https://www.ncbi.nlm.nih.gov/pubmed/25468267 DMUHFLQ DI DMUHFLQ DMUHFLQ DN N-oxalylglycine derivative 1 DMUHFLQ MI TT0RGE9 DMUHFLQ MN Lysine-specific demethylase 4 (KDM4) DMUHFLQ MT DTT DMUHFLQ MA Inhibitor DMUHFLQ RN KDM4 histone demethylase inhibitors for anti-cancer agents: a patent review.Expert Opin Ther Pat. 2015 Feb;25(2):135-44. DMUHFLQ RU https://www.ncbi.nlm.nih.gov/pubmed/25468267 DMDJC96 DI DMDJC96 DMDJC96 DN N-oxalylglycine derivative 2 DMDJC96 MI TT0RGE9 DMDJC96 MN Lysine-specific demethylase 4 (KDM4) DMDJC96 MT DTT DMDJC96 MA Inhibitor DMDJC96 RN KDM4 histone demethylase inhibitors for anti-cancer agents: a patent review.Expert Opin Ther Pat. 2015 Feb;25(2):135-44. DMDJC96 RU https://www.ncbi.nlm.nih.gov/pubmed/25468267 DMQF0RY DI DMQF0RY DMQF0RY DN N-oxalylglycine derivative 3 DMQF0RY MI TT0RGE9 DMQF0RY MN Lysine-specific demethylase 4 (KDM4) DMQF0RY MT DTT DMQF0RY MA Inhibitor DMQF0RY RN KDM4 histone demethylase inhibitors for anti-cancer agents: a patent review.Expert Opin Ther Pat. 2015 Feb;25(2):135-44. DMQF0RY RU https://www.ncbi.nlm.nih.gov/pubmed/25468267 DM9A8L5 DI DM9A8L5 DM9A8L5 DN N-phenyl-5-phenyl-pyrazolin-3-yl amide derivative 1 DM9A8L5 MI TT6OEDT DM9A8L5 MN Cannabinoid receptor 1 (CB1) DM9A8L5 MT DTT DM9A8L5 MA Antagonist DM9A8L5 RN A comprehensive patents review on cannabinoid 1 receptor antagonists as antiobesity agents. Expert Opin Ther Pat. 2015 Oct;25(10):1093-116. DM9A8L5 RU https://pubmed.ncbi.nlm.nih.gov/26161824 DM8T2LV DI DM8T2LV DM8T2LV DN N-phenyl-5-phenyl-pyrazolin-3-yl amide derivative 2 DM8T2LV MI TT6OEDT DM8T2LV MN Cannabinoid receptor 1 (CB1) DM8T2LV MT DTT DM8T2LV MA Antagonist DM8T2LV RN A comprehensive patents review on cannabinoid 1 receptor antagonists as antiobesity agents. Expert Opin Ther Pat. 2015 Oct;25(10):1093-116. DM8T2LV RU https://pubmed.ncbi.nlm.nih.gov/26161824 DMEH0RC DI DMEH0RC DMEH0RC DN N-phenyl-5-phenyl-pyrazolin-3-yl amide derivative 3 DMEH0RC MI TT6OEDT DMEH0RC MN Cannabinoid receptor 1 (CB1) DMEH0RC MT DTT DMEH0RC MA Antagonist DMEH0RC RN A comprehensive patents review on cannabinoid 1 receptor antagonists as antiobesity agents. Expert Opin Ther Pat. 2015 Oct;25(10):1093-116. DMEH0RC RU https://pubmed.ncbi.nlm.nih.gov/26161824 DMMDYAV DI DMMDYAV DMMDYAV DN N-phenyl-pyridine-2-carboxamide derivative 1 DMMDYAV MI TT23XQV DMMDYAV MN PD-1-PD-L1 interaction (PD-1/PD-L1 PPI) DMMDYAV MT DTT DMMDYAV MA Inhibitor DMMDYAV RN A patent review on PD-1/PD-L1 antagonists: small molecules, peptides, and macrocycles (2015-2018).Expert Opin Ther Pat. 2018 Sep;28(9):665-678. DMMDYAV RU https://www.ncbi.nlm.nih.gov/pubmed/30107136 DM6OG2Y DI DM6OG2Y DM6OG2Y DN N-phenyl-pyridine-2-carboxamide derivative 2 DM6OG2Y MI TT23XQV DM6OG2Y MN PD-1-PD-L1 interaction (PD-1/PD-L1 PPI) DM6OG2Y MT DTT DM6OG2Y MA Inhibitor DM6OG2Y RN A patent review on PD-1/PD-L1 antagonists: small molecules, peptides, and macrocycles (2015-2018).Expert Opin Ther Pat. 2018 Sep;28(9):665-678. DM6OG2Y RU https://www.ncbi.nlm.nih.gov/pubmed/30107136 DMAV8LM DI DMAV8LM DMAV8LM DN N-phenyl-pyrimidin-4-amine derivative 1 DMAV8LM MI TT7HF4W DMAV8LM MN Cyclin-dependent kinase 2 (CDK2) DMAV8LM MT DTT DMAV8LM MA Inhibitor DMAV8LM RN Cyclin-dependent kinase inhibitors for cancer therapy: a patent review (2009 - 2014).Expert Opin Ther Pat. 2015;25(9):953-70. DMAV8LM RU https://www.ncbi.nlm.nih.gov/pubmed/26161698 DMAV8LM DI DMAV8LM DMAV8LM DN N-phenyl-pyrimidin-4-amine derivative 1 DMAV8LM MI TT1LVF2 DMAV8LM MN Cyclin-dependent kinase 9 (CDK9) DMAV8LM MT DTT DMAV8LM MA Inhibitor DMAV8LM RN Cyclin-dependent kinase inhibitors for cancer therapy: a patent review (2009 - 2014).Expert Opin Ther Pat. 2015;25(9):953-70. DMAV8LM RU https://www.ncbi.nlm.nih.gov/pubmed/26161698 DMLSK97 DI DMLSK97 DMLSK97 DN N-quinolin-benzene sulphonamide derivative 1 DMLSK97 MI TTSXVID DMLSK97 MN Nuclear factor NF-kappa-B (NFKB) DMLSK97 MT DTT DMLSK97 MA Inhibitor DMLSK97 RN Novel NF-B inhibitors: a patent review (2011 - 2014).Expert Opin Ther Pat. 2015 Mar;25(3):319-34. DMLSK97 RU https://www.ncbi.nlm.nih.gov/pubmed/25553724 DMH65CX DI DMH65CX DMH65CX DN N-quinolin-benzene sulphonamide derivative 2 DMH65CX MI TTSXVID DMH65CX MN Nuclear factor NF-kappa-B (NFKB) DMH65CX MT DTT DMH65CX MA Inhibitor DMH65CX RN Novel NF-B inhibitors: a patent review (2011 - 2014).Expert Opin Ther Pat. 2015 Mar;25(3):319-34. DMH65CX RU https://www.ncbi.nlm.nih.gov/pubmed/25553724 DMU65YX DI DMU65YX DMU65YX DN N-quinolin-benzene sulphonamide derivative 3 DMU65YX MI TTSXVID DMU65YX MN Nuclear factor NF-kappa-B (NFKB) DMU65YX MT DTT DMU65YX MA Inhibitor DMU65YX RN Novel NF-B inhibitors: a patent review (2011 - 2014).Expert Opin Ther Pat. 2015 Mar;25(3):319-34. DMU65YX RU https://www.ncbi.nlm.nih.gov/pubmed/25553724 DMEYKXL DI DMEYKXL DMEYKXL DN NSC-87877 DMEYKXL MI TT369M5 DMEYKXL MN Protein-tyrosine phosphatase SHP-1 (PTPN6) DMEYKXL MT DTT DMEYKXL MA Inhibitor DMEYKXL RN Inhibition of Shp2/PTPN11 protein tyrosine phosphatase by NSC-87877, NSC-117199 and their analogs. US8987474. DMEYKXL RU http://www.freepatentsonline.com/US8987474.html DMEYKXL DI DMEYKXL DMEYKXL DN NSC-87877 DMEYKXL MI TT7WUAV DMEYKXL MN Protein-tyrosine phosphatase SHP-2 (PTPN11) DMEYKXL MT DTT DMEYKXL MA Inhibitor DMEYKXL RN Inhibitors of Src homology-2 domain containing protein tyrosine phosphatase-2 (Shp2) based on oxindole scaffolds. J Med Chem. 2008 Aug 28;51(16):4948-56. DMEYKXL RU https://pubmed.ncbi.nlm.nih.gov/18680359 DMSU80N DI DMSU80N DMSU80N DN N-substituted 9-azabicyclo[3.3.1]nonan-3alpha-yl-phenylcarbamate analog 1 DMSU80N MI TT9NXW4 DMSU80N MN Sigma intracellular receptor 2 (TMEM97) DMSU80N MT DTT DMSU80N MA Ligand DMSU80N RN Are sigma modulators an effective opportunity for cancer treatment A patent overview (1996-2016).Expert Opin Ther Pat. 2017 May;27(5):565-578. DMSU80N RU https://www.ncbi.nlm.nih.gov/pubmed/28051882 DMPW1GI DI DMPW1GI DMPW1GI DN N-substituted 9-azabicyclo[3.3.1]nonan-3alpha-yl-phenylcarbamate analog 2 DMPW1GI MI TT9NXW4 DMPW1GI MN Sigma intracellular receptor 2 (TMEM97) DMPW1GI MT DTT DMPW1GI MA Ligand DMPW1GI RN Are sigma modulators an effective opportunity for cancer treatment A patent overview (1996-2016).Expert Opin Ther Pat. 2017 May;27(5):565-578. DMPW1GI RU https://www.ncbi.nlm.nih.gov/pubmed/28051882 DMZF9TM DI DMZF9TM DMZF9TM DN N-substituted 9-azabicyclo[3.3.1]nonan-3alpha-yl-phenylcarbamate analog 3 DMZF9TM MI TT9NXW4 DMZF9TM MN Sigma intracellular receptor 2 (TMEM97) DMZF9TM MT DTT DMZF9TM MA Ligand DMZF9TM RN Are sigma modulators an effective opportunity for cancer treatment A patent overview (1996-2016).Expert Opin Ther Pat. 2017 May;27(5):565-578. DMZF9TM RU https://www.ncbi.nlm.nih.gov/pubmed/28051882 DMHTVGM DI DMHTVGM DMHTVGM DN N-substituted pyrazole derivative 1 DMHTVGM MI TTXJ47W DMHTVGM MN Metabotropic glutamate receptor 2 (mGluR2) DMHTVGM MT DTT DMHTVGM MA Antagonist DMHTVGM RN Novel metabotropic glutamate receptor 2/3 antagonists and their therapeutic applications: a patent review (2005 - present).Expert Opin Ther Pat. 2015 Jan;25(1):69-90. DMHTVGM RU https://www.ncbi.nlm.nih.gov/pubmed/25435285 DMQWODI DI DMQWODI DMQWODI DN N-substituted pyrazole derivative 2 DMQWODI MI TTXJ47W DMQWODI MN Metabotropic glutamate receptor 2 (mGluR2) DMQWODI MT DTT DMQWODI MA Antagonist DMQWODI RN Novel metabotropic glutamate receptor 2/3 antagonists and their therapeutic applications: a patent review (2005 - present).Expert Opin Ther Pat. 2015 Jan;25(1):69-90. DMQWODI RU https://www.ncbi.nlm.nih.gov/pubmed/25435285 DM5TIFH DI DM5TIFH DM5TIFH DN N-substituted pyrazole derivative 3 DM5TIFH MI TTXJ47W DM5TIFH MN Metabotropic glutamate receptor 2 (mGluR2) DM5TIFH MT DTT DM5TIFH MA Antagonist DM5TIFH RN Novel metabotropic glutamate receptor 2/3 antagonists and their therapeutic applications: a patent review (2005 - present).Expert Opin Ther Pat. 2015 Jan;25(1):69-90. DM5TIFH RU https://www.ncbi.nlm.nih.gov/pubmed/25435285 DM0ECWR DI DM0ECWR DM0ECWR DN Octahydro-pyrrolo[3,4-c]-pyrrole derivative 1 DM0ECWR MI TTSCIM2 DM0ECWR MN Extracellular lysophospholipase D (E-NPP2) DM0ECWR MT DTT DM0ECWR MA Inhibitor DM0ECWR RN Autotaxin inhibitors: a patent review (2012-2016).Expert Opin Ther Pat. 2017 Jul;27(7):815-829. DM0ECWR RU https://www.ncbi.nlm.nih.gov/pubmed/28447479 DMZIALN DI DMZIALN DMZIALN DN Olenolic acid acetate derivative 1 DMZIALN MI TTSXVID DMZIALN MN Nuclear factor NF-kappa-B (NFKB) DMZIALN MT DTT DMZIALN MA Inhibitor DMZIALN RN Novel NF-B inhibitors: a patent review (2011 - 2014).Expert Opin Ther Pat. 2015 Mar;25(3):319-34. DMZIALN RU https://www.ncbi.nlm.nih.gov/pubmed/25553724 DM74T5L DI DM74T5L DM74T5L DN Oligooxopiperazine derivative 1 DM74T5L MI TTUX68I DM74T5L MN Hypoxia-inducible factor 1 (HIF-1) DM74T5L MT DTT DM74T5L MA Inhibitor DM74T5L RN Hypoxia-inducible factor (HIF) inhibitors: a patent survey (2011-2015).Expert Opin Ther Pat. 2016;26(3):309-22. DM74T5L RU https://www.ncbi.nlm.nih.gov/pubmed/26882240 DM7Y2RL DI DM7Y2RL DM7Y2RL DN Oxazole derivative 1 DM7Y2RL MI TTN7R6K DM7Y2RL MN Signal transducer and activator of transcription 1 (STAT1) DM7Y2RL MT DTT DM7Y2RL MA Inhibitor DM7Y2RL RN A STAT inhibitor patent review: progress since 2011.Expert Opin Ther Pat. 2015;25(12):1397-421. DM7Y2RL RU https://www.ncbi.nlm.nih.gov/pubmed/26394986 DM7Y2RL DI DM7Y2RL DM7Y2RL DN Oxazole derivative 1 DM7Y2RL MI TTH8FZW DM7Y2RL MN Signal transducer and activator of transcription 3 (STAT3) DM7Y2RL MT DTT DM7Y2RL MA Inhibitor DM7Y2RL RN A STAT inhibitor patent review: progress since 2011.Expert Opin Ther Pat. 2015;25(12):1397-421. DM7Y2RL RU https://www.ncbi.nlm.nih.gov/pubmed/26394986 DMPZ81S DI DMPZ81S DMPZ81S DN Oxazolo[3,4-a]pyrazine derivative 1 DMPZ81S MI TTV1C0Z DMPZ81S MN Neuropeptide S receptor (NPSR) DMPZ81S MT DTT DMPZ81S MA Antagonist DMPZ81S RN Neuropeptide S receptor ligands: a patent review (2005-2016).Expert Opin Ther Pat. 2017 Mar;27(3):347-362. DMPZ81S RU https://www.ncbi.nlm.nih.gov/pubmed/27788040 DM28E0A DI DM28E0A DM28E0A DN Oxazolo[3,4-a]pyrazine derivative 2 DM28E0A MI TTV1C0Z DM28E0A MN Neuropeptide S receptor (NPSR) DM28E0A MT DTT DM28E0A MA Antagonist DM28E0A RN Neuropeptide S receptor ligands: a patent review (2005-2016).Expert Opin Ther Pat. 2017 Mar;27(3):347-362. DM28E0A RU https://www.ncbi.nlm.nih.gov/pubmed/27788040 DM1LPKH DI DM1LPKH DM1LPKH DN Oxazolo[3,4-a]pyrazine derivative 3 DM1LPKH MI TTV1C0Z DM1LPKH MN Neuropeptide S receptor (NPSR) DM1LPKH MT DTT DM1LPKH MA Antagonist DM1LPKH RN Neuropeptide S receptor ligands: a patent review (2005-2016).Expert Opin Ther Pat. 2017 Mar;27(3):347-362. DM1LPKH RU https://www.ncbi.nlm.nih.gov/pubmed/27788040 DM1B74D DI DM1B74D DM1B74D DN Oxazolo[3,4-a]pyrazine derivative 4 DM1B74D MI TTV1C0Z DM1B74D MN Neuropeptide S receptor (NPSR) DM1B74D MT DTT DM1B74D MA Antagonist DM1B74D RN Neuropeptide S receptor ligands: a patent review (2005-2016).Expert Opin Ther Pat. 2017 Mar;27(3):347-362. DM1B74D RU https://www.ncbi.nlm.nih.gov/pubmed/27788040 DMC5G76 DI DMC5G76 DMC5G76 DN Oxazolo[3,4-a]pyrazine derivative 5 DMC5G76 MI TTV1C0Z DMC5G76 MN Neuropeptide S receptor (NPSR) DMC5G76 MT DTT DMC5G76 MA Antagonist DMC5G76 RN Neuropeptide S receptor ligands: a patent review (2005-2016).Expert Opin Ther Pat. 2017 Mar;27(3):347-362. DMC5G76 RU https://www.ncbi.nlm.nih.gov/pubmed/27788040 DM5DC9A DI DM5DC9A DM5DC9A DN Oxazolo[3,4-a]pyrazine derivative 6 DM5DC9A MI TTV1C0Z DM5DC9A MN Neuropeptide S receptor (NPSR) DM5DC9A MT DTT DM5DC9A MA Antagonist DM5DC9A RN Neuropeptide S receptor ligands: a patent review (2005-2016).Expert Opin Ther Pat. 2017 Mar;27(3):347-362. DM5DC9A RU https://www.ncbi.nlm.nih.gov/pubmed/27788040 DMEX5VK DI DMEX5VK DMEX5VK DN Oxazolo[3,4-a]pyrazine derivative 7 DMEX5VK MI TTV1C0Z DMEX5VK MN Neuropeptide S receptor (NPSR) DMEX5VK MT DTT DMEX5VK MA Antagonist DMEX5VK RN Neuropeptide S receptor ligands: a patent review (2005-2016).Expert Opin Ther Pat. 2017 Mar;27(3):347-362. DMEX5VK RU https://www.ncbi.nlm.nih.gov/pubmed/27788040 DMZM6FW DI DMZM6FW DMZM6FW DN Oxazolyl methylthiothiazole derivative 1 DMZM6FW MI TTH6V3D DMZM6FW MN Cyclin-dependent kinase 1 (CDK1) DMZM6FW MT DTT DMZM6FW MA Inhibitor DMZM6FW RN Cyclin-dependent kinase inhibitors for cancer therapy: a patent review (2009 - 2014).Expert Opin Ther Pat. 2015;25(9):953-70. DMZM6FW RU https://www.ncbi.nlm.nih.gov/pubmed/26161698 DMZM6FW DI DMZM6FW DMZM6FW DN Oxazolyl methylthiothiazole derivative 1 DMZM6FW MI TT7HF4W DMZM6FW MN Cyclin-dependent kinase 2 (CDK2) DMZM6FW MT DTT DMZM6FW MA Inhibitor DMZM6FW RN Cyclin-dependent kinase inhibitors for cancer therapy: a patent review (2009 - 2014).Expert Opin Ther Pat. 2015;25(9):953-70. DMZM6FW RU https://www.ncbi.nlm.nih.gov/pubmed/26161698 DMZM6FW DI DMZM6FW DMZM6FW DN Oxazolyl methylthiothiazole derivative 1 DMZM6FW MI TTMYWL7 DMZM6FW MN Cyclin-dependent kinase 3 (CDK3) DMZM6FW MT DTT DMZM6FW MA Inhibitor DMZM6FW RN Cyclin-dependent kinase inhibitors for cancer therapy: a patent review (2009 - 2014).Expert Opin Ther Pat. 2015;25(9):953-70. DMZM6FW RU https://www.ncbi.nlm.nih.gov/pubmed/26161698 DMZM6FW DI DMZM6FW DMZM6FW DN Oxazolyl methylthiothiazole derivative 1 DMZM6FW MI TT0PG8F DMZM6FW MN Cyclin-dependent kinase 4 (CDK4) DMZM6FW MT DTT DMZM6FW MA Inhibitor DMZM6FW RN Cyclin-dependent kinase inhibitors for cancer therapy: a patent review (2009 - 2014).Expert Opin Ther Pat. 2015;25(9):953-70. DMZM6FW RU https://www.ncbi.nlm.nih.gov/pubmed/26161698 DMZM6FW DI DMZM6FW DMZM6FW DN Oxazolyl methylthiothiazole derivative 1 DMZM6FW MI TTO0FDJ DMZM6FW MN Cyclin-dependent kinase 6 (CDK6) DMZM6FW MT DTT DMZM6FW MA Inhibitor DMZM6FW RN Cyclin-dependent kinase inhibitors for cancer therapy: a patent review (2009 - 2014).Expert Opin Ther Pat. 2015;25(9):953-70. DMZM6FW RU https://www.ncbi.nlm.nih.gov/pubmed/26161698 DMZM6FW DI DMZM6FW DMZM6FW DN Oxazolyl methylthiothiazole derivative 1 DMZM6FW MI TTQYF7G DMZM6FW MN Cyclin-dependent kinase 7 (CDK7) DMZM6FW MT DTT DMZM6FW MA Inhibitor DMZM6FW RN Cyclin-dependent kinase inhibitors for cancer therapy: a patent review (2009 - 2014).Expert Opin Ther Pat. 2015;25(9):953-70. DMZM6FW RU https://www.ncbi.nlm.nih.gov/pubmed/26161698 DMZM6FW DI DMZM6FW DMZM6FW DN Oxazolyl methylthiothiazole derivative 1 DMZM6FW MI TT1LVF2 DMZM6FW MN Cyclin-dependent kinase 9 (CDK9) DMZM6FW MT DTT DMZM6FW MA Inhibitor DMZM6FW RN Cyclin-dependent kinase inhibitors for cancer therapy: a patent review (2009 - 2014).Expert Opin Ther Pat. 2015;25(9):953-70. DMZM6FW RU https://www.ncbi.nlm.nih.gov/pubmed/26161698 DMZM6FW DI DMZM6FW DMZM6FW DN Oxazolyl methylthiothiazole derivative 1 DMZM6FW MI TTBH0VX DMZM6FW MN Histone deacetylase (HDAC) DMZM6FW MT DTT DMZM6FW MA Inhibitor DMZM6FW RN Cyclin-dependent kinase inhibitors for cancer therapy: a patent review (2009 - 2014).Expert Opin Ther Pat. 2015;25(9):953-70. DMZM6FW RU https://www.ncbi.nlm.nih.gov/pubmed/26161698 DMSB09X DI DMSB09X DMSB09X DN Oxetane 3,3-dicarboxamide compound 1 DMSB09X MI TTOHSBA DMSB09X MN Vascular endothelial growth factor A (VEGFA) DMSB09X MT DTT DMSB09X MA Inhibitor DMSB09X RN VEGFR-2 inhibitors and the therapeutic applications thereof: a patent review (2012-2016).Expert Opin Ther Pat. 2017 Sep;27(9):987-1004. DMSB09X RU https://www.ncbi.nlm.nih.gov/pubmed/28621580 DMMCTAK DI DMMCTAK DMMCTAK DN Oxetane 3,3-dicarboxamide compound 2 DMMCTAK MI TTOHSBA DMMCTAK MN Vascular endothelial growth factor A (VEGFA) DMMCTAK MT DTT DMMCTAK MA Inhibitor DMMCTAK RN VEGFR-2 inhibitors and the therapeutic applications thereof: a patent review (2012-2016).Expert Opin Ther Pat. 2017 Sep;27(9):987-1004. DMMCTAK RU https://www.ncbi.nlm.nih.gov/pubmed/28621580 DMWUYIB DI DMWUYIB DMWUYIB DN Oxime derivative 1 DMWUYIB MI TTEB0GD DMWUYIB MN Cholinesterase (BCHE) DMWUYIB MT DTT DMWUYIB MA Reactivator DMWUYIB RN A patent review of butyrylcholinesterase inhibitors and reactivators 2010-2017.Expert Opin Ther Pat. 2018 Jun;28(6):455-465. DMWUYIB RU https://www.ncbi.nlm.nih.gov/pubmed/29757691 DMMSVW5 DI DMMSVW5 DMMSVW5 DN Oxindole derivative 1 DMMSVW5 MI TTJGW1Z DMMSVW5 MN Phosphodiesterase 2A (PDE2A) DMMSVW5 MT DTT DMMSVW5 MA Inhibitor DMMSVW5 RN Towards selective phosphodiesterase 2A (PDE2A) inhibitors: a patent review (2010 - present).Expert Opin Ther Pat. 2016 Aug;26(8):933-46. DMMSVW5 RU https://www.ncbi.nlm.nih.gov/pubmed/27321640 DM6ZYMC DI DM6ZYMC DM6ZYMC DN Oxindole derivative 2 DM6ZYMC MI TTK0FEA DM6ZYMC MN Leucine-rich repeat kinase 2 (LRRK2) DM6ZYMC MT DTT DM6ZYMC MA Inhibitor DM6ZYMC RN Leucine-rich repeat kinase 2 inhibitors: a patent review (2014-2016).Expert Opin Ther Pat. 2017 Jun;27(6):667-676. DM6ZYMC RU https://www.ncbi.nlm.nih.gov/pubmed/28117607 DM0ENF3 DI DM0ENF3 DM0ENF3 DN Oxindole derivative 3 DM0ENF3 MI TTK0FEA DM0ENF3 MN Leucine-rich repeat kinase 2 (LRRK2) DM0ENF3 MT DTT DM0ENF3 MA Inhibitor DM0ENF3 RN Leucine-rich repeat kinase 2 inhibitors: a patent review (2014-2016).Expert Opin Ther Pat. 2017 Jun;27(6):667-676. DM0ENF3 RU https://www.ncbi.nlm.nih.gov/pubmed/28117607 DM0ENF3 DI DM0ENF3 DM0ENF3 DN Oxindole derivative 3 DM0ENF3 MI TT6AXLY DM0ENF3 MN Leucine-rich repeat kinase 2 G2019S mutant (LRRK2 G2019S) DM0ENF3 MT DTT DM0ENF3 MA Inhibitor DM0ENF3 RN Leucine-rich repeat kinase 2 inhibitors: a patent review (2014-2016).Expert Opin Ther Pat. 2017 Jun;27(6):667-676. DM0ENF3 RU https://www.ncbi.nlm.nih.gov/pubmed/28117607 DM3U58I DI DM3U58I DM3U58I DN Oxindole derivative 4 DM3U58I MI TTK0FEA DM3U58I MN Leucine-rich repeat kinase 2 (LRRK2) DM3U58I MT DTT DM3U58I MA Inhibitor DM3U58I RN Leucine-rich repeat kinase 2 inhibitors: a patent review (2014-2016).Expert Opin Ther Pat. 2017 Jun;27(6):667-676. DM3U58I RU https://www.ncbi.nlm.nih.gov/pubmed/28117607 DM3U58I DI DM3U58I DM3U58I DN Oxindole derivative 4 DM3U58I MI TT6AXLY DM3U58I MN Leucine-rich repeat kinase 2 G2019S mutant (LRRK2 G2019S) DM3U58I MT DTT DM3U58I MA Inhibitor DM3U58I RN Leucine-rich repeat kinase 2 inhibitors: a patent review (2014-2016).Expert Opin Ther Pat. 2017 Jun;27(6):667-676. DM3U58I RU https://www.ncbi.nlm.nih.gov/pubmed/28117607 DM1SH5R DI DM1SH5R DM1SH5R DN Oxotetrahydro-2-H-furo[3.2-b]pyrrol-4(5-H)-yl derivative 1 DM1SH5R MI TTDZN01 DM1SH5R MN Cathepsin K (CTSK) DM1SH5R MT DTT DM1SH5R MA Inhibitor DM1SH5R RN Cathepsin B and L inhibitors: a patent review (2010 - present).Expert Opin Ther Pat. 2017 Jun;27(6):643-656. DM1SH5R RU https://www.ncbi.nlm.nih.gov/pubmed/27998201 DM1SH5R DI DM1SH5R DM1SH5R DN Oxotetrahydro-2-H-furo[3.2-b]pyrrol-4(5-H)-yl derivative 1 DM1SH5R MI TTUMQVO DM1SH5R MN Cathepsin S (CTSS) DM1SH5R MT DTT DM1SH5R MA Inhibitor DM1SH5R RN Cathepsin B and L inhibitors: a patent review (2010 - present).Expert Opin Ther Pat. 2017 Jun;27(6):643-656. DM1SH5R RU https://www.ncbi.nlm.nih.gov/pubmed/27998201 DM0RI7F DI DM0RI7F DM0RI7F DN Palbociclib/ribociclib analog 1 DM0RI7F MI TT7HF4W DM0RI7F MN Cyclin-dependent kinase 2 (CDK2) DM0RI7F MT DTT DM0RI7F MA Inhibitor DM0RI7F RN Cyclin-dependent kinase inhibitors for cancer therapy: a patent review (2009 - 2014).Expert Opin Ther Pat. 2015;25(9):953-70. DM0RI7F RU https://www.ncbi.nlm.nih.gov/pubmed/26161698 DM0RI7F DI DM0RI7F DM0RI7F DN Palbociclib/ribociclib analog 1 DM0RI7F MI TT0PG8F DM0RI7F MN Cyclin-dependent kinase 4 (CDK4) DM0RI7F MT DTT DM0RI7F MA Inhibitor DM0RI7F RN Cyclin-dependent kinase inhibitors for cancer therapy: a patent review (2009 - 2014).Expert Opin Ther Pat. 2015;25(9):953-70. DM0RI7F RU https://www.ncbi.nlm.nih.gov/pubmed/26161698 DM859ZQ DI DM859ZQ DM859ZQ DN Palmarumycin derivative 1 DM859ZQ MI TTR7UJ3 DM859ZQ MN Cytoplasmic thioredoxin reductase (TXNRD1) DM859ZQ MT DTT DM859ZQ MA Inhibitor DM859ZQ RN Thioredoxin reductase inhibitors: a patent review.Expert Opin Ther Pat. 2017 May;27(5):547-556. DM859ZQ RU https://www.ncbi.nlm.nih.gov/pubmed/27977313 DMRLWZI DI DMRLWZI DMRLWZI DN Palmarumycin derivative 2 DMRLWZI MI TTR7UJ3 DMRLWZI MN Cytoplasmic thioredoxin reductase (TXNRD1) DMRLWZI MT DTT DMRLWZI MA Inhibitor DMRLWZI RN Thioredoxin reductase inhibitors: a patent review.Expert Opin Ther Pat. 2017 May;27(5):547-556. DMRLWZI RU https://www.ncbi.nlm.nih.gov/pubmed/27977313 DM198BY DI DM198BY DM198BY DN Palmarumycin derivative 3 DM198BY MI TTR7UJ3 DM198BY MN Cytoplasmic thioredoxin reductase (TXNRD1) DM198BY MT DTT DM198BY MA Inhibitor DM198BY RN Thioredoxin reductase inhibitors: a patent review.Expert Opin Ther Pat. 2017 May;27(5):547-556. DM198BY RU https://www.ncbi.nlm.nih.gov/pubmed/27977313 DMZGI0R DI DMZGI0R DMZGI0R DN Palmarumycin derivative 4 DMZGI0R MI TTR7UJ3 DMZGI0R MN Cytoplasmic thioredoxin reductase (TXNRD1) DMZGI0R MT DTT DMZGI0R MA Inhibitor DMZGI0R RN Thioredoxin reductase inhibitors: a patent review.Expert Opin Ther Pat. 2017 May;27(5):547-556. DMZGI0R RU https://www.ncbi.nlm.nih.gov/pubmed/27977313 DM231WS DI DM231WS DM231WS DN P-coumaric acid derivative 1 DM231WS MI TTULVH8 DM231WS MN Tyrosinase (TYR) DM231WS MT DTT DM231WS MA Inhibitor DM231WS RN Tyrosinase inhibitors: a patent review (2011-2015).Expert Opin Ther Pat. 2016;26(3):347-62. DM231WS RU https://www.ncbi.nlm.nih.gov/pubmed/26815044 DMFTZBY DI DMFTZBY DMFTZBY DN P-coumaric acid derivative 2 DMFTZBY MI TTULVH8 DMFTZBY MN Tyrosinase (TYR) DMFTZBY MT DTT DMFTZBY MA Inhibitor DMFTZBY RN Tyrosinase inhibitors: a patent review (2011-2015).Expert Opin Ther Pat. 2016;26(3):347-62. DMFTZBY RU https://www.ncbi.nlm.nih.gov/pubmed/26815044 DMFE4IY DI DMFE4IY DMFE4IY DN P-coumaric acid derivative 3 DMFE4IY MI TTULVH8 DMFE4IY MN Tyrosinase (TYR) DMFE4IY MT DTT DMFE4IY MA Inhibitor DMFE4IY RN Tyrosinase inhibitors: a patent review (2011-2015).Expert Opin Ther Pat. 2016;26(3):347-62. DMFE4IY RU https://www.ncbi.nlm.nih.gov/pubmed/26815044 DM5WQP3 DI DM5WQP3 DM5WQP3 DN P-coumaric acid derivative 4 DM5WQP3 MI TTULVH8 DM5WQP3 MN Tyrosinase (TYR) DM5WQP3 MT DTT DM5WQP3 MA Inhibitor DM5WQP3 RN Tyrosinase inhibitors: a patent review (2011-2015).Expert Opin Ther Pat. 2016;26(3):347-62. DM5WQP3 RU https://www.ncbi.nlm.nih.gov/pubmed/26815044 DMFKGZ7 DI DMFKGZ7 DMFKGZ7 DN P-coumaric acid derivative 5 DMFKGZ7 MI TTULVH8 DMFKGZ7 MN Tyrosinase (TYR) DMFKGZ7 MT DTT DMFKGZ7 MA Inhibitor DMFKGZ7 RN Tyrosinase inhibitors: a patent review (2011-2015).Expert Opin Ther Pat. 2016;26(3):347-62. DMFKGZ7 RU https://www.ncbi.nlm.nih.gov/pubmed/26815044 DMF4YGC DI DMF4YGC DMF4YGC DN P-coumaric acid derivative 6 DMF4YGC MI TTULVH8 DMF4YGC MN Tyrosinase (TYR) DMF4YGC MT DTT DMF4YGC MA Inhibitor DMF4YGC RN Tyrosinase inhibitors: a patent review (2011-2015).Expert Opin Ther Pat. 2016;26(3):347-62. DMF4YGC RU https://www.ncbi.nlm.nih.gov/pubmed/26815044 DMF3LIX DI DMF3LIX DMF3LIX DN Peptide analog 1 DMF3LIX MI TT23XQV DMF3LIX MN PD-1-PD-L1 interaction (PD-1/PD-L1 PPI) DMF3LIX MT DTT DMF3LIX MA Inhibitor DMF3LIX RN A patent review on PD-1/PD-L1 antagonists: small molecules, peptides, and macrocycles (2015-2018).Expert Opin Ther Pat. 2018 Sep;28(9):665-678. DMF3LIX RU https://www.ncbi.nlm.nih.gov/pubmed/30107136 DMYKOAM DI DMYKOAM DMYKOAM DN Peptide analog 10 DMYKOAM MI TTSJMN8 DMYKOAM MN Immunoproteasome complex (IP) DMYKOAM MT DTT DMYKOAM MA Inhibitor DMYKOAM RN A patent review of immunoproteasome inhibitors.Expert Opin Ther Pat. 2018 Jul;28(7):517-540. DMYKOAM RU https://www.ncbi.nlm.nih.gov/pubmed/29865878 DML9C64 DI DML9C64 DML9C64 DN Peptide analog 11 DML9C64 MI TT68GPI DML9C64 MN Proteasome beta-5 (PS beta-5) DML9C64 MT DTT DML9C64 MA Inhibitor DML9C64 RN A patent review of immunoproteasome inhibitors.Expert Opin Ther Pat. 2018 Jul;28(7):517-540. DML9C64 RU https://www.ncbi.nlm.nih.gov/pubmed/29865878 DML9C64 DI DML9C64 DML9C64 DN Peptide analog 11 DML9C64 MI TTEAD9J DML9C64 MN Proteasome beta-8 (PS beta-8) DML9C64 MT DTT DML9C64 MA Inhibitor DML9C64 RN A patent review of immunoproteasome inhibitors.Expert Opin Ther Pat. 2018 Jul;28(7):517-540. DML9C64 RU https://www.ncbi.nlm.nih.gov/pubmed/29865878 DMSJHV3 DI DMSJHV3 DMSJHV3 DN Peptide analog 12 DMSJHV3 MI TTSJMN8 DMSJHV3 MN Immunoproteasome complex (IP) DMSJHV3 MT DTT DMSJHV3 MA Inhibitor DMSJHV3 RN A patent review of immunoproteasome inhibitors.Expert Opin Ther Pat. 2018 Jul;28(7):517-540. DMSJHV3 RU https://www.ncbi.nlm.nih.gov/pubmed/29865878 DMWI6V3 DI DMWI6V3 DMWI6V3 DN Peptide analog 13 DMWI6V3 MI TT68GPI DMWI6V3 MN Proteasome beta-5 (PS beta-5) DMWI6V3 MT DTT DMWI6V3 MA Inhibitor DMWI6V3 RN A patent review of immunoproteasome inhibitors.Expert Opin Ther Pat. 2018 Jul;28(7):517-540. DMWI6V3 RU https://www.ncbi.nlm.nih.gov/pubmed/29865878 DMWI6V3 DI DMWI6V3 DMWI6V3 DN Peptide analog 13 DMWI6V3 MI TTEAD9J DMWI6V3 MN Proteasome beta-8 (PS beta-8) DMWI6V3 MT DTT DMWI6V3 MA Inhibitor DMWI6V3 RN A patent review of immunoproteasome inhibitors.Expert Opin Ther Pat. 2018 Jul;28(7):517-540. DMWI6V3 RU https://www.ncbi.nlm.nih.gov/pubmed/29865878 DMN97QF DI DMN97QF DMN97QF DN Peptide analog 14 DMN97QF MI TTOUSTQ DMN97QF MN Proteasome beta-9 (PS beta-9) DMN97QF MT DTT DMN97QF MA Inhibitor DMN97QF RN A patent review of immunoproteasome inhibitors.Expert Opin Ther Pat. 2018 Jul;28(7):517-540. DMN97QF RU https://www.ncbi.nlm.nih.gov/pubmed/29865878 DM0K5Q1 DI DM0K5Q1 DM0K5Q1 DN Peptide analog 15 DM0K5Q1 MI TTSJMN8 DM0K5Q1 MN Immunoproteasome complex (IP) DM0K5Q1 MT DTT DM0K5Q1 MA Inhibitor DM0K5Q1 RN A patent review of immunoproteasome inhibitors.Expert Opin Ther Pat. 2018 Jul;28(7):517-540. DM0K5Q1 RU https://www.ncbi.nlm.nih.gov/pubmed/29865878 DMKJ27D DI DMKJ27D DMKJ27D DN Peptide analog 16 DMKJ27D MI TTSJMN8 DMKJ27D MN Immunoproteasome complex (IP) DMKJ27D MT DTT DMKJ27D MA Inhibitor DMKJ27D RN A patent review of immunoproteasome inhibitors.Expert Opin Ther Pat. 2018 Jul;28(7):517-540. DMKJ27D RU https://www.ncbi.nlm.nih.gov/pubmed/29865878 DMJ91EM DI DMJ91EM DMJ91EM DN Peptide analog 17 DMJ91EM MI TT68GPI DMJ91EM MN Proteasome beta-5 (PS beta-5) DMJ91EM MT DTT DMJ91EM MA Inhibitor DMJ91EM RN A patent review of immunoproteasome inhibitors.Expert Opin Ther Pat. 2018 Jul;28(7):517-540. DMJ91EM RU https://www.ncbi.nlm.nih.gov/pubmed/29865878 DMJ91EM DI DMJ91EM DMJ91EM DN Peptide analog 17 DMJ91EM MI TTEAD9J DMJ91EM MN Proteasome beta-8 (PS beta-8) DMJ91EM MT DTT DMJ91EM MA Inhibitor DMJ91EM RN A patent review of immunoproteasome inhibitors.Expert Opin Ther Pat. 2018 Jul;28(7):517-540. DMJ91EM RU https://www.ncbi.nlm.nih.gov/pubmed/29865878 DMF1TR6 DI DMF1TR6 DMF1TR6 DN Peptide analog 18 DMF1TR6 MI TTSJMN8 DMF1TR6 MN Immunoproteasome complex (IP) DMF1TR6 MT DTT DMF1TR6 MA Inhibitor DMF1TR6 RN A patent review of immunoproteasome inhibitors.Expert Opin Ther Pat. 2018 Jul;28(7):517-540. DMF1TR6 RU https://www.ncbi.nlm.nih.gov/pubmed/29865878 DMLIVT6 DI DMLIVT6 DMLIVT6 DN Peptide analog 19 DMLIVT6 MI TT68GPI DMLIVT6 MN Proteasome beta-5 (PS beta-5) DMLIVT6 MT DTT DMLIVT6 MA Inhibitor DMLIVT6 RN A patent review of immunoproteasome inhibitors.Expert Opin Ther Pat. 2018 Jul;28(7):517-540. DMLIVT6 RU https://www.ncbi.nlm.nih.gov/pubmed/29865878 DMLIVT6 DI DMLIVT6 DMLIVT6 DN Peptide analog 19 DMLIVT6 MI TTEAD9J DMLIVT6 MN Proteasome beta-8 (PS beta-8) DMLIVT6 MT DTT DMLIVT6 MA Inhibitor DMLIVT6 RN A patent review of immunoproteasome inhibitors.Expert Opin Ther Pat. 2018 Jul;28(7):517-540. DMLIVT6 RU https://www.ncbi.nlm.nih.gov/pubmed/29865878 DMYFUM6 DI DMYFUM6 DMYFUM6 DN Peptide analog 2 DMYFUM6 MI TT23XQV DMYFUM6 MN PD-1-PD-L1 interaction (PD-1/PD-L1 PPI) DMYFUM6 MT DTT DMYFUM6 MA Inhibitor DMYFUM6 RN A patent review on PD-1/PD-L1 antagonists: small molecules, peptides, and macrocycles (2015-2018).Expert Opin Ther Pat. 2018 Sep;28(9):665-678. DMYFUM6 RU https://www.ncbi.nlm.nih.gov/pubmed/30107136 DM2L9KI DI DM2L9KI DM2L9KI DN Peptide analog 20 DM2L9KI MI TTSJMN8 DM2L9KI MN Immunoproteasome complex (IP) DM2L9KI MT DTT DM2L9KI MA Inhibitor DM2L9KI RN A patent review of immunoproteasome inhibitors.Expert Opin Ther Pat. 2018 Jul;28(7):517-540. DM2L9KI RU https://www.ncbi.nlm.nih.gov/pubmed/29865878 DMJDFS1 DI DMJDFS1 DMJDFS1 DN Peptide analog 21 DMJDFS1 MI TT8EPLT DMJDFS1 MN Proteasome beta-1 (PS beta-1) DMJDFS1 MT DTT DMJDFS1 MA Inhibitor DMJDFS1 RN A patent review of immunoproteasome inhibitors.Expert Opin Ther Pat. 2018 Jul;28(7):517-540. DMJDFS1 RU https://www.ncbi.nlm.nih.gov/pubmed/29865878 DMJDFS1 DI DMJDFS1 DMJDFS1 DN Peptide analog 21 DMJDFS1 MI TTPNACM DMJDFS1 MN Proteasome beta-10 (PS beta-10) DMJDFS1 MT DTT DMJDFS1 MA Inhibitor DMJDFS1 RN A patent review of immunoproteasome inhibitors.Expert Opin Ther Pat. 2018 Jul;28(7):517-540. DMJDFS1 RU https://www.ncbi.nlm.nih.gov/pubmed/29865878 DMJDFS1 DI DMJDFS1 DMJDFS1 DN Peptide analog 21 DMJDFS1 MI TT49BVC DMJDFS1 MN Proteasome beta-2 (PS beta-2) DMJDFS1 MT DTT DMJDFS1 MA Inhibitor DMJDFS1 RN A patent review of immunoproteasome inhibitors.Expert Opin Ther Pat. 2018 Jul;28(7):517-540. DMJDFS1 RU https://www.ncbi.nlm.nih.gov/pubmed/29865878 DMJDFS1 DI DMJDFS1 DMJDFS1 DN Peptide analog 21 DMJDFS1 MI TT68GPI DMJDFS1 MN Proteasome beta-5 (PS beta-5) DMJDFS1 MT DTT DMJDFS1 MA Inhibitor DMJDFS1 RN A patent review of immunoproteasome inhibitors.Expert Opin Ther Pat. 2018 Jul;28(7):517-540. DMJDFS1 RU https://www.ncbi.nlm.nih.gov/pubmed/29865878 DMJDFS1 DI DMJDFS1 DMJDFS1 DN Peptide analog 21 DMJDFS1 MI TTEAD9J DMJDFS1 MN Proteasome beta-8 (PS beta-8) DMJDFS1 MT DTT DMJDFS1 MA Inhibitor DMJDFS1 RN A patent review of immunoproteasome inhibitors.Expert Opin Ther Pat. 2018 Jul;28(7):517-540. DMJDFS1 RU https://www.ncbi.nlm.nih.gov/pubmed/29865878 DMJDFS1 DI DMJDFS1 DMJDFS1 DN Peptide analog 21 DMJDFS1 MI TTOUSTQ DMJDFS1 MN Proteasome beta-9 (PS beta-9) DMJDFS1 MT DTT DMJDFS1 MA Inhibitor DMJDFS1 RN A patent review of immunoproteasome inhibitors.Expert Opin Ther Pat. 2018 Jul;28(7):517-540. DMJDFS1 RU https://www.ncbi.nlm.nih.gov/pubmed/29865878 DMTLO1E DI DMTLO1E DMTLO1E DN Peptide analog 22 DMTLO1E MI TTSJMN8 DMTLO1E MN Immunoproteasome complex (IP) DMTLO1E MT DTT DMTLO1E MA Inhibitor DMTLO1E RN A patent review of immunoproteasome inhibitors.Expert Opin Ther Pat. 2018 Jul;28(7):517-540. DMTLO1E RU https://www.ncbi.nlm.nih.gov/pubmed/29865878 DMDU21R DI DMDU21R DMDU21R DN Peptide analog 23 DMDU21R MI TT8EPLT DMDU21R MN Proteasome beta-1 (PS beta-1) DMDU21R MT DTT DMDU21R MA Inhibitor DMDU21R RN A patent review of immunoproteasome inhibitors.Expert Opin Ther Pat. 2018 Jul;28(7):517-540. DMDU21R RU https://www.ncbi.nlm.nih.gov/pubmed/29865878 DMDU21R DI DMDU21R DMDU21R DN Peptide analog 23 DMDU21R MI TTPNACM DMDU21R MN Proteasome beta-10 (PS beta-10) DMDU21R MT DTT DMDU21R MA Inhibitor DMDU21R RN A patent review of immunoproteasome inhibitors.Expert Opin Ther Pat. 2018 Jul;28(7):517-540. DMDU21R RU https://www.ncbi.nlm.nih.gov/pubmed/29865878 DMDU21R DI DMDU21R DMDU21R DN Peptide analog 23 DMDU21R MI TT49BVC DMDU21R MN Proteasome beta-2 (PS beta-2) DMDU21R MT DTT DMDU21R MA Inhibitor DMDU21R RN A patent review of immunoproteasome inhibitors.Expert Opin Ther Pat. 2018 Jul;28(7):517-540. DMDU21R RU https://www.ncbi.nlm.nih.gov/pubmed/29865878 DMDU21R DI DMDU21R DMDU21R DN Peptide analog 23 DMDU21R MI TT68GPI DMDU21R MN Proteasome beta-5 (PS beta-5) DMDU21R MT DTT DMDU21R MA Inhibitor DMDU21R RN A patent review of immunoproteasome inhibitors.Expert Opin Ther Pat. 2018 Jul;28(7):517-540. DMDU21R RU https://www.ncbi.nlm.nih.gov/pubmed/29865878 DMDU21R DI DMDU21R DMDU21R DN Peptide analog 23 DMDU21R MI TTEAD9J DMDU21R MN Proteasome beta-8 (PS beta-8) DMDU21R MT DTT DMDU21R MA Inhibitor DMDU21R RN A patent review of immunoproteasome inhibitors.Expert Opin Ther Pat. 2018 Jul;28(7):517-540. DMDU21R RU https://www.ncbi.nlm.nih.gov/pubmed/29865878 DMDU21R DI DMDU21R DMDU21R DN Peptide analog 23 DMDU21R MI TTOUSTQ DMDU21R MN Proteasome beta-9 (PS beta-9) DMDU21R MT DTT DMDU21R MA Inhibitor DMDU21R RN A patent review of immunoproteasome inhibitors.Expert Opin Ther Pat. 2018 Jul;28(7):517-540. DMDU21R RU https://www.ncbi.nlm.nih.gov/pubmed/29865878 DM904T7 DI DM904T7 DM904T7 DN Peptide analog 24 DM904T7 MI TTSJMN8 DM904T7 MN Immunoproteasome complex (IP) DM904T7 MT DTT DM904T7 MA Inhibitor DM904T7 RN A patent review of immunoproteasome inhibitors.Expert Opin Ther Pat. 2018 Jul;28(7):517-540. DM904T7 RU https://www.ncbi.nlm.nih.gov/pubmed/29865878 DMFBQHZ DI DMFBQHZ DMFBQHZ DN Peptide analog 25 DMFBQHZ MI TT68GPI DMFBQHZ MN Proteasome beta-5 (PS beta-5) DMFBQHZ MT DTT DMFBQHZ MA Inhibitor DMFBQHZ RN A patent review of immunoproteasome inhibitors.Expert Opin Ther Pat. 2018 Jul;28(7):517-540. DMFBQHZ RU https://www.ncbi.nlm.nih.gov/pubmed/29865878 DMFBQHZ DI DMFBQHZ DMFBQHZ DN Peptide analog 25 DMFBQHZ MI TTEAD9J DMFBQHZ MN Proteasome beta-8 (PS beta-8) DMFBQHZ MT DTT DMFBQHZ MA Inhibitor DMFBQHZ RN A patent review of immunoproteasome inhibitors.Expert Opin Ther Pat. 2018 Jul;28(7):517-540. DMFBQHZ RU https://www.ncbi.nlm.nih.gov/pubmed/29865878 DM8FGZB DI DM8FGZB DM8FGZB DN Peptide analog 26 DM8FGZB MI TTSJMN8 DM8FGZB MN Immunoproteasome complex (IP) DM8FGZB MT DTT DM8FGZB MA Inhibitor DM8FGZB RN A patent review of immunoproteasome inhibitors.Expert Opin Ther Pat. 2018 Jul;28(7):517-540. DM8FGZB RU https://www.ncbi.nlm.nih.gov/pubmed/29865878 DML4XJ2 DI DML4XJ2 DML4XJ2 DN Peptide analog 27 DML4XJ2 MI TT68GPI DML4XJ2 MN Proteasome beta-5 (PS beta-5) DML4XJ2 MT DTT DML4XJ2 MA Inhibitor DML4XJ2 RN A patent review of immunoproteasome inhibitors.Expert Opin Ther Pat. 2018 Jul;28(7):517-540. DML4XJ2 RU https://www.ncbi.nlm.nih.gov/pubmed/29865878 DML4XJ2 DI DML4XJ2 DML4XJ2 DN Peptide analog 27 DML4XJ2 MI TTEAD9J DML4XJ2 MN Proteasome beta-8 (PS beta-8) DML4XJ2 MT DTT DML4XJ2 MA Inhibitor DML4XJ2 RN A patent review of immunoproteasome inhibitors.Expert Opin Ther Pat. 2018 Jul;28(7):517-540. DML4XJ2 RU https://www.ncbi.nlm.nih.gov/pubmed/29865878 DMHT4PF DI DMHT4PF DMHT4PF DN Peptide analog 28 DMHT4PF MI TT68GPI DMHT4PF MN Proteasome beta-5 (PS beta-5) DMHT4PF MT DTT DMHT4PF MA Inhibitor DMHT4PF RN A patent review of immunoproteasome inhibitors.Expert Opin Ther Pat. 2018 Jul;28(7):517-540. DMHT4PF RU https://www.ncbi.nlm.nih.gov/pubmed/29865878 DMHT4PF DI DMHT4PF DMHT4PF DN Peptide analog 28 DMHT4PF MI TTEAD9J DMHT4PF MN Proteasome beta-8 (PS beta-8) DMHT4PF MT DTT DMHT4PF MA Inhibitor DMHT4PF RN A patent review of immunoproteasome inhibitors.Expert Opin Ther Pat. 2018 Jul;28(7):517-540. DMHT4PF RU https://www.ncbi.nlm.nih.gov/pubmed/29865878 DM1NMR6 DI DM1NMR6 DM1NMR6 DN Peptide analog 29 DM1NMR6 MI TTSJMN8 DM1NMR6 MN Immunoproteasome complex (IP) DM1NMR6 MT DTT DM1NMR6 MA Inhibitor DM1NMR6 RN A patent review of immunoproteasome inhibitors.Expert Opin Ther Pat. 2018 Jul;28(7):517-540. DM1NMR6 RU https://www.ncbi.nlm.nih.gov/pubmed/29865878 DMYMJV3 DI DMYMJV3 DMYMJV3 DN Peptide analog 3 DMYMJV3 MI TT23XQV DMYMJV3 MN PD-1-PD-L1 interaction (PD-1/PD-L1 PPI) DMYMJV3 MT DTT DMYMJV3 MA Inhibitor DMYMJV3 RN A patent review on PD-1/PD-L1 antagonists: small molecules, peptides, and macrocycles (2015-2018).Expert Opin Ther Pat. 2018 Sep;28(9):665-678. DMYMJV3 RU https://www.ncbi.nlm.nih.gov/pubmed/30107136 DMYEJV0 DI DMYEJV0 DMYEJV0 DN Peptide analog 30 DMYEJV0 MI TTSJMN8 DMYEJV0 MN Immunoproteasome complex (IP) DMYEJV0 MT DTT DMYEJV0 MA Inhibitor DMYEJV0 RN A patent review of immunoproteasome inhibitors.Expert Opin Ther Pat. 2018 Jul;28(7):517-540. DMYEJV0 RU https://www.ncbi.nlm.nih.gov/pubmed/29865878 DMS9O6I DI DMS9O6I DMS9O6I DN Peptide analog 31 DMS9O6I MI TT68GPI DMS9O6I MN Proteasome beta-5 (PS beta-5) DMS9O6I MT DTT DMS9O6I MA Inhibitor DMS9O6I RN A patent review of immunoproteasome inhibitors.Expert Opin Ther Pat. 2018 Jul;28(7):517-540. DMS9O6I RU https://www.ncbi.nlm.nih.gov/pubmed/29865878 DMS9O6I DI DMS9O6I DMS9O6I DN Peptide analog 31 DMS9O6I MI TTEAD9J DMS9O6I MN Proteasome beta-8 (PS beta-8) DMS9O6I MT DTT DMS9O6I MA Inhibitor DMS9O6I RN A patent review of immunoproteasome inhibitors.Expert Opin Ther Pat. 2018 Jul;28(7):517-540. DMS9O6I RU https://www.ncbi.nlm.nih.gov/pubmed/29865878 DMGQ1PK DI DMGQ1PK DMGQ1PK DN Peptide analog 32 DMGQ1PK MI TTSJMN8 DMGQ1PK MN Immunoproteasome complex (IP) DMGQ1PK MT DTT DMGQ1PK MA Inhibitor DMGQ1PK RN A patent review of immunoproteasome inhibitors.Expert Opin Ther Pat. 2018 Jul;28(7):517-540. DMGQ1PK RU https://www.ncbi.nlm.nih.gov/pubmed/29865878 DML5P6O DI DML5P6O DML5P6O DN Peptide analog 33 DML5P6O MI TT68GPI DML5P6O MN Proteasome beta-5 (PS beta-5) DML5P6O MT DTT DML5P6O MA Inhibitor DML5P6O RN A patent review of immunoproteasome inhibitors.Expert Opin Ther Pat. 2018 Jul;28(7):517-540. DML5P6O RU https://www.ncbi.nlm.nih.gov/pubmed/29865878 DML5P6O DI DML5P6O DML5P6O DN Peptide analog 33 DML5P6O MI TTEAD9J DML5P6O MN Proteasome beta-8 (PS beta-8) DML5P6O MT DTT DML5P6O MA Inhibitor DML5P6O RN A patent review of immunoproteasome inhibitors.Expert Opin Ther Pat. 2018 Jul;28(7):517-540. DML5P6O RU https://www.ncbi.nlm.nih.gov/pubmed/29865878 DMG4EOP DI DMG4EOP DMG4EOP DN Peptide analog 34 DMG4EOP MI TT68GPI DMG4EOP MN Proteasome beta-5 (PS beta-5) DMG4EOP MT DTT DMG4EOP MA Inhibitor DMG4EOP RN A patent review of immunoproteasome inhibitors.Expert Opin Ther Pat. 2018 Jul;28(7):517-540. DMG4EOP RU https://www.ncbi.nlm.nih.gov/pubmed/29865878 DMG4EOP DI DMG4EOP DMG4EOP DN Peptide analog 34 DMG4EOP MI TTEAD9J DMG4EOP MN Proteasome beta-8 (PS beta-8) DMG4EOP MT DTT DMG4EOP MA Inhibitor DMG4EOP RN A patent review of immunoproteasome inhibitors.Expert Opin Ther Pat. 2018 Jul;28(7):517-540. DMG4EOP RU https://www.ncbi.nlm.nih.gov/pubmed/29865878 DMSOQG7 DI DMSOQG7 DMSOQG7 DN Peptide analog 35 DMSOQG7 MI TTSJMN8 DMSOQG7 MN Immunoproteasome complex (IP) DMSOQG7 MT DTT DMSOQG7 MA Inhibitor DMSOQG7 RN A patent review of immunoproteasome inhibitors.Expert Opin Ther Pat. 2018 Jul;28(7):517-540. DMSOQG7 RU https://www.ncbi.nlm.nih.gov/pubmed/29865878 DMB4LNI DI DMB4LNI DMB4LNI DN Peptide analog 36 DMB4LNI MI TTPNACM DMB4LNI MN Proteasome beta-10 (PS beta-10) DMB4LNI MT DTT DMB4LNI MA Inhibitor DMB4LNI RN A patent review of immunoproteasome inhibitors.Expert Opin Ther Pat. 2018 Jul;28(7):517-540. DMB4LNI RU https://www.ncbi.nlm.nih.gov/pubmed/29865878 DMB4LNI DI DMB4LNI DMB4LNI DN Peptide analog 36 DMB4LNI MI TT49BVC DMB4LNI MN Proteasome beta-2 (PS beta-2) DMB4LNI MT DTT DMB4LNI MA Inhibitor DMB4LNI RN A patent review of immunoproteasome inhibitors.Expert Opin Ther Pat. 2018 Jul;28(7):517-540. DMB4LNI RU https://www.ncbi.nlm.nih.gov/pubmed/29865878 DMB4LNI DI DMB4LNI DMB4LNI DN Peptide analog 36 DMB4LNI MI TT68GPI DMB4LNI MN Proteasome beta-5 (PS beta-5) DMB4LNI MT DTT DMB4LNI MA Inhibitor DMB4LNI RN A patent review of immunoproteasome inhibitors.Expert Opin Ther Pat. 2018 Jul;28(7):517-540. DMB4LNI RU https://www.ncbi.nlm.nih.gov/pubmed/29865878 DMVX71N DI DMVX71N DMVX71N DN Peptide analog 37 DMVX71N MI TTPNACM DMVX71N MN Proteasome beta-10 (PS beta-10) DMVX71N MT DTT DMVX71N MA Inhibitor DMVX71N RN A patent review of immunoproteasome inhibitors.Expert Opin Ther Pat. 2018 Jul;28(7):517-540. DMVX71N RU https://www.ncbi.nlm.nih.gov/pubmed/29865878 DMVX71N DI DMVX71N DMVX71N DN Peptide analog 37 DMVX71N MI TT49BVC DMVX71N MN Proteasome beta-2 (PS beta-2) DMVX71N MT DTT DMVX71N MA Inhibitor DMVX71N RN A patent review of immunoproteasome inhibitors.Expert Opin Ther Pat. 2018 Jul;28(7):517-540. DMVX71N RU https://www.ncbi.nlm.nih.gov/pubmed/29865878 DMVX71N DI DMVX71N DMVX71N DN Peptide analog 37 DMVX71N MI TT68GPI DMVX71N MN Proteasome beta-5 (PS beta-5) DMVX71N MT DTT DMVX71N MA Inhibitor DMVX71N RN A patent review of immunoproteasome inhibitors.Expert Opin Ther Pat. 2018 Jul;28(7):517-540. DMVX71N RU https://www.ncbi.nlm.nih.gov/pubmed/29865878 DM9FL81 DI DM9FL81 DM9FL81 DN Peptide analog 38 DM9FL81 MI TTPNACM DM9FL81 MN Proteasome beta-10 (PS beta-10) DM9FL81 MT DTT DM9FL81 MA Inhibitor DM9FL81 RN A patent review of immunoproteasome inhibitors.Expert Opin Ther Pat. 2018 Jul;28(7):517-540. DM9FL81 RU https://www.ncbi.nlm.nih.gov/pubmed/29865878 DM9FL81 DI DM9FL81 DM9FL81 DN Peptide analog 38 DM9FL81 MI TT49BVC DM9FL81 MN Proteasome beta-2 (PS beta-2) DM9FL81 MT DTT DM9FL81 MA Inhibitor DM9FL81 RN A patent review of immunoproteasome inhibitors.Expert Opin Ther Pat. 2018 Jul;28(7):517-540. DM9FL81 RU https://www.ncbi.nlm.nih.gov/pubmed/29865878 DM9FL81 DI DM9FL81 DM9FL81 DN Peptide analog 38 DM9FL81 MI TT68GPI DM9FL81 MN Proteasome beta-5 (PS beta-5) DM9FL81 MT DTT DM9FL81 MA Inhibitor DM9FL81 RN A patent review of immunoproteasome inhibitors.Expert Opin Ther Pat. 2018 Jul;28(7):517-540. DM9FL81 RU https://www.ncbi.nlm.nih.gov/pubmed/29865878 DMYJOTP DI DMYJOTP DMYJOTP DN Peptide analog 39 DMYJOTP MI TT8EPLT DMYJOTP MN Proteasome beta-1 (PS beta-1) DMYJOTP MT DTT DMYJOTP MA Inhibitor DMYJOTP RN A patent review of immunoproteasome inhibitors.Expert Opin Ther Pat. 2018 Jul;28(7):517-540. DMYJOTP RU https://www.ncbi.nlm.nih.gov/pubmed/29865878 DMYJOTP DI DMYJOTP DMYJOTP DN Peptide analog 39 DMYJOTP MI TT49BVC DMYJOTP MN Proteasome beta-2 (PS beta-2) DMYJOTP MT DTT DMYJOTP MA Inhibitor DMYJOTP RN A patent review of immunoproteasome inhibitors.Expert Opin Ther Pat. 2018 Jul;28(7):517-540. DMYJOTP RU https://www.ncbi.nlm.nih.gov/pubmed/29865878 DMYJOTP DI DMYJOTP DMYJOTP DN Peptide analog 39 DMYJOTP MI TT68GPI DMYJOTP MN Proteasome beta-5 (PS beta-5) DMYJOTP MT DTT DMYJOTP MA Inhibitor DMYJOTP RN A patent review of immunoproteasome inhibitors.Expert Opin Ther Pat. 2018 Jul;28(7):517-540. DMYJOTP RU https://www.ncbi.nlm.nih.gov/pubmed/29865878 DM5KEVG DI DM5KEVG DM5KEVG DN Peptide analog 4 DM5KEVG MI TT23XQV DM5KEVG MN PD-1-PD-L1 interaction (PD-1/PD-L1 PPI) DM5KEVG MT DTT DM5KEVG MA Inhibitor DM5KEVG RN A patent review on PD-1/PD-L1 antagonists: small molecules, peptides, and macrocycles (2015-2018).Expert Opin Ther Pat. 2018 Sep;28(9):665-678. DM5KEVG RU https://www.ncbi.nlm.nih.gov/pubmed/30107136 DM12VO9 DI DM12VO9 DM12VO9 DN Peptide analog 40 DM12VO9 MI TTSJMN8 DM12VO9 MN Immunoproteasome complex (IP) DM12VO9 MT DTT DM12VO9 MA Inhibitor DM12VO9 RN A patent review of immunoproteasome inhibitors.Expert Opin Ther Pat. 2018 Jul;28(7):517-540. DM12VO9 RU https://www.ncbi.nlm.nih.gov/pubmed/29865878 DM96KXE DI DM96KXE DM96KXE DN Peptide analog 41 DM96KXE MI TT8EPLT DM96KXE MN Proteasome beta-1 (PS beta-1) DM96KXE MT DTT DM96KXE MA Inhibitor DM96KXE RN A patent review of immunoproteasome inhibitors.Expert Opin Ther Pat. 2018 Jul;28(7):517-540. DM96KXE RU https://www.ncbi.nlm.nih.gov/pubmed/29865878 DM96KXE DI DM96KXE DM96KXE DN Peptide analog 41 DM96KXE MI TT49BVC DM96KXE MN Proteasome beta-2 (PS beta-2) DM96KXE MT DTT DM96KXE MA Inhibitor DM96KXE RN A patent review of immunoproteasome inhibitors.Expert Opin Ther Pat. 2018 Jul;28(7):517-540. DM96KXE RU https://www.ncbi.nlm.nih.gov/pubmed/29865878 DM96KXE DI DM96KXE DM96KXE DN Peptide analog 41 DM96KXE MI TT68GPI DM96KXE MN Proteasome beta-5 (PS beta-5) DM96KXE MT DTT DM96KXE MA Inhibitor DM96KXE RN A patent review of immunoproteasome inhibitors.Expert Opin Ther Pat. 2018 Jul;28(7):517-540. DM96KXE RU https://www.ncbi.nlm.nih.gov/pubmed/29865878 DM96KXE DI DM96KXE DM96KXE DN Peptide analog 41 DM96KXE MI TTEAD9J DM96KXE MN Proteasome beta-8 (PS beta-8) DM96KXE MT DTT DM96KXE MA Inhibitor DM96KXE RN A patent review of immunoproteasome inhibitors.Expert Opin Ther Pat. 2018 Jul;28(7):517-540. DM96KXE RU https://www.ncbi.nlm.nih.gov/pubmed/29865878 DM96KXE DI DM96KXE DM96KXE DN Peptide analog 41 DM96KXE MI TTOUSTQ DM96KXE MN Proteasome beta-9 (PS beta-9) DM96KXE MT DTT DM96KXE MA Inhibitor DM96KXE RN A patent review of immunoproteasome inhibitors.Expert Opin Ther Pat. 2018 Jul;28(7):517-540. DM96KXE RU https://www.ncbi.nlm.nih.gov/pubmed/29865878 DMF1MZ4 DI DMF1MZ4 DMF1MZ4 DN Peptide analog 42 DMF1MZ4 MI TTSJMN8 DMF1MZ4 MN Immunoproteasome complex (IP) DMF1MZ4 MT DTT DMF1MZ4 MA Inhibitor DMF1MZ4 RN A patent review of immunoproteasome inhibitors.Expert Opin Ther Pat. 2018 Jul;28(7):517-540. DMF1MZ4 RU https://www.ncbi.nlm.nih.gov/pubmed/29865878 DMYMPF9 DI DMYMPF9 DMYMPF9 DN Peptide analog 43 DMYMPF9 MI TTSJMN8 DMYMPF9 MN Immunoproteasome complex (IP) DMYMPF9 MT DTT DMYMPF9 MA Inhibitor DMYMPF9 RN A patent review of immunoproteasome inhibitors.Expert Opin Ther Pat. 2018 Jul;28(7):517-540. DMYMPF9 RU https://www.ncbi.nlm.nih.gov/pubmed/29865878 DMOJDQF DI DMOJDQF DMOJDQF DN Peptide analog 44 DMOJDQF MI TTDIGC1 DMOJDQF MN Dipeptidyl peptidase 4 (DPP-4) DMOJDQF MT DTT DMOJDQF MA Inhibitor DMOJDQF RN DPP-4 inhibitors: a patent review (2012 - 2014).Expert Opin Ther Pat. 2015 Feb;25(2):209-36. DMOJDQF RU https://www.ncbi.nlm.nih.gov/pubmed/25482888 DMGA3U8 DI DMGA3U8 DMGA3U8 DN Peptide analog 45 DMGA3U8 MI TTDIGC1 DMGA3U8 MN Dipeptidyl peptidase 4 (DPP-4) DMGA3U8 MT DTT DMGA3U8 MA Inhibitor DMGA3U8 RN DPP-4 inhibitors: a patent review (2012 - 2014).Expert Opin Ther Pat. 2015 Feb;25(2):209-36. DMGA3U8 RU https://www.ncbi.nlm.nih.gov/pubmed/25482888 DMC48AX DI DMC48AX DMC48AX DN Peptide analog 46 DMC48AX MI TTDIGC1 DMC48AX MN Dipeptidyl peptidase 4 (DPP-4) DMC48AX MT DTT DMC48AX MA Inhibitor DMC48AX RN DPP-4 inhibitors: a patent review (2012 - 2014).Expert Opin Ther Pat. 2015 Feb;25(2):209-36. DMC48AX RU https://www.ncbi.nlm.nih.gov/pubmed/25482888 DM7U8WD DI DM7U8WD DM7U8WD DN Peptide analog 47 DM7U8WD MI TTDIGC1 DM7U8WD MN Dipeptidyl peptidase 4 (DPP-4) DM7U8WD MT DTT DM7U8WD MA Inhibitor DM7U8WD RN DPP-4 inhibitors: a patent review (2012 - 2014).Expert Opin Ther Pat. 2015 Feb;25(2):209-36. DM7U8WD RU https://www.ncbi.nlm.nih.gov/pubmed/25482888 DMM2WA4 DI DMM2WA4 DMM2WA4 DN Peptide analog 48 DMM2WA4 MI TTDIGC1 DMM2WA4 MN Dipeptidyl peptidase 4 (DPP-4) DMM2WA4 MT DTT DMM2WA4 MA Inhibitor DMM2WA4 RN DPP-4 inhibitors: a patent review (2012 - 2014).Expert Opin Ther Pat. 2015 Feb;25(2):209-36. DMM2WA4 RU https://www.ncbi.nlm.nih.gov/pubmed/25482888 DMP5SA2 DI DMP5SA2 DMP5SA2 DN Peptide analog 49 DMP5SA2 MI TTDIGC1 DMP5SA2 MN Dipeptidyl peptidase 4 (DPP-4) DMP5SA2 MT DTT DMP5SA2 MA Inhibitor DMP5SA2 RN DPP-4 inhibitors: a patent review (2012 - 2014).Expert Opin Ther Pat. 2015 Feb;25(2):209-36. DMP5SA2 RU https://www.ncbi.nlm.nih.gov/pubmed/25482888 DM8B13I DI DM8B13I DM8B13I DN Peptide analog 5 DM8B13I MI TT23XQV DM8B13I MN PD-1-PD-L1 interaction (PD-1/PD-L1 PPI) DM8B13I MT DTT DM8B13I MA Inhibitor DM8B13I RN A patent review on PD-1/PD-L1 antagonists: small molecules, peptides, and macrocycles (2015-2018).Expert Opin Ther Pat. 2018 Sep;28(9):665-678. DM8B13I RU https://www.ncbi.nlm.nih.gov/pubmed/30107136 DMM8K7R DI DMM8K7R DMM8K7R DN Peptide analog 50 DMM8K7R MI TTDIGC1 DMM8K7R MN Dipeptidyl peptidase 4 (DPP-4) DMM8K7R MT DTT DMM8K7R MA Inhibitor DMM8K7R RN DPP-4 inhibitors: a patent review (2012 - 2014).Expert Opin Ther Pat. 2015 Feb;25(2):209-36. DMM8K7R RU https://www.ncbi.nlm.nih.gov/pubmed/25482888 DM1D7CE DI DM1D7CE DM1D7CE DN Peptide analog 51 DM1D7CE MI TTDIGC1 DM1D7CE MN Dipeptidyl peptidase 4 (DPP-4) DM1D7CE MT DTT DM1D7CE MA Inhibitor DM1D7CE RN DPP-4 inhibitors: a patent review (2012 - 2014).Expert Opin Ther Pat. 2015 Feb;25(2):209-36. DM1D7CE RU https://www.ncbi.nlm.nih.gov/pubmed/25482888 DMDG5T9 DI DMDG5T9 DMDG5T9 DN Peptide analog 52 DMDG5T9 MI TT2F4OL DMDG5T9 MN Tissue transglutaminase (TG2) DMDG5T9 MT DTT DMDG5T9 MA Inhibitor DMDG5T9 RN Transglutaminase inhibitors: a patent review.Expert Opin Ther Pat. 2016;26(1):49-63. DMDG5T9 RU https://www.ncbi.nlm.nih.gov/pubmed/26560530 DM9FJXS DI DM9FJXS DM9FJXS DN Peptide analog 53 DM9FJXS MI TT2F4OL DM9FJXS MN Tissue transglutaminase (TG2) DM9FJXS MT DTT DM9FJXS MA Inhibitor DM9FJXS RN Transglutaminase inhibitors: a patent review.Expert Opin Ther Pat. 2016;26(1):49-63. DM9FJXS RU https://www.ncbi.nlm.nih.gov/pubmed/26560530 DMZVB5U DI DMZVB5U DMZVB5U DN Peptide analog 54 DMZVB5U MI TT2F4OL DMZVB5U MN Tissue transglutaminase (TG2) DMZVB5U MT DTT DMZVB5U MA Inhibitor DMZVB5U RN Transglutaminase inhibitors: a patent review.Expert Opin Ther Pat. 2016;26(1):49-63. DMZVB5U RU https://www.ncbi.nlm.nih.gov/pubmed/26560530 DMVLP8H DI DMVLP8H DMVLP8H DN Peptide analog 55 DMVLP8H MI TTQAJF1 DMVLP8H MN Cathepsin G (CTSG) DMVLP8H MT DTT DMVLP8H MA Inhibitor DMVLP8H RN Neutrophil elastase inhibitors: a patent review and potential applications for inflammatory lung diseases (2010 - 2014).Expert Opin Ther Pat. 2015;25(10):1145-58. DMVLP8H RU https://www.ncbi.nlm.nih.gov/pubmed/26118988 DMVLP8H DI DMVLP8H DMVLP8H DN Peptide analog 55 DMVLP8H MI TTPLTSQ DMVLP8H MN Neutrophil elastase (NE) DMVLP8H MT DTT DMVLP8H MA Inhibitor DMVLP8H RN Neutrophil elastase inhibitors: a patent review and potential applications for inflammatory lung diseases (2010 - 2014).Expert Opin Ther Pat. 2015;25(10):1145-58. DMVLP8H RU https://www.ncbi.nlm.nih.gov/pubmed/26118988 DMBCFJU DI DMBCFJU DMBCFJU DN Peptide analog 56 DMBCFJU MI TTQAJF1 DMBCFJU MN Cathepsin G (CTSG) DMBCFJU MT DTT DMBCFJU MA Inhibitor DMBCFJU RN Neutrophil elastase inhibitors: a patent review and potential applications for inflammatory lung diseases (2010 - 2014).Expert Opin Ther Pat. 2015;25(10):1145-58. DMBCFJU RU https://www.ncbi.nlm.nih.gov/pubmed/26118988 DMBCFJU DI DMBCFJU DMBCFJU DN Peptide analog 56 DMBCFJU MI TTPLTSQ DMBCFJU MN Neutrophil elastase (NE) DMBCFJU MT DTT DMBCFJU MA Inhibitor DMBCFJU RN Neutrophil elastase inhibitors: a patent review and potential applications for inflammatory lung diseases (2010 - 2014).Expert Opin Ther Pat. 2015;25(10):1145-58. DMBCFJU RU https://www.ncbi.nlm.nih.gov/pubmed/26118988 DM6IQWE DI DM6IQWE DM6IQWE DN Peptide analog 57 DM6IQWE MI TTQAJF1 DM6IQWE MN Cathepsin G (CTSG) DM6IQWE MT DTT DM6IQWE MA Inhibitor DM6IQWE RN Neutrophil elastase inhibitors: a patent review and potential applications for inflammatory lung diseases (2010 - 2014).Expert Opin Ther Pat. 2015;25(10):1145-58. DM6IQWE RU https://www.ncbi.nlm.nih.gov/pubmed/26118988 DM6IQWE DI DM6IQWE DM6IQWE DN Peptide analog 57 DM6IQWE MI TTPLTSQ DM6IQWE MN Neutrophil elastase (NE) DM6IQWE MT DTT DM6IQWE MA Inhibitor DM6IQWE RN Neutrophil elastase inhibitors: a patent review and potential applications for inflammatory lung diseases (2010 - 2014).Expert Opin Ther Pat. 2015;25(10):1145-58. DM6IQWE RU https://www.ncbi.nlm.nih.gov/pubmed/26118988 DM7X62M DI DM7X62M DM7X62M DN Peptide analog 58 DM7X62M MI TTQAJF1 DM7X62M MN Cathepsin G (CTSG) DM7X62M MT DTT DM7X62M MA Inhibitor DM7X62M RN Neutrophil elastase inhibitors: a patent review and potential applications for inflammatory lung diseases (2010 - 2014).Expert Opin Ther Pat. 2015;25(10):1145-58. DM7X62M RU https://www.ncbi.nlm.nih.gov/pubmed/26118988 DM7X62M DI DM7X62M DM7X62M DN Peptide analog 58 DM7X62M MI TTPLTSQ DM7X62M MN Neutrophil elastase (NE) DM7X62M MT DTT DM7X62M MA Inhibitor DM7X62M RN Neutrophil elastase inhibitors: a patent review and potential applications for inflammatory lung diseases (2010 - 2014).Expert Opin Ther Pat. 2015;25(10):1145-58. DM7X62M RU https://www.ncbi.nlm.nih.gov/pubmed/26118988 DMZAMNX DI DMZAMNX DMZAMNX DN Peptide analog 59 DMZAMNX MI TTQAJF1 DMZAMNX MN Cathepsin G (CTSG) DMZAMNX MT DTT DMZAMNX MA Inhibitor DMZAMNX RN Neutrophil elastase inhibitors: a patent review and potential applications for inflammatory lung diseases (2010 - 2014).Expert Opin Ther Pat. 2015;25(10):1145-58. DMZAMNX RU https://www.ncbi.nlm.nih.gov/pubmed/26118988 DMZAMNX DI DMZAMNX DMZAMNX DN Peptide analog 59 DMZAMNX MI TTPLTSQ DMZAMNX MN Neutrophil elastase (NE) DMZAMNX MT DTT DMZAMNX MA Inhibitor DMZAMNX RN Neutrophil elastase inhibitors: a patent review and potential applications for inflammatory lung diseases (2010 - 2014).Expert Opin Ther Pat. 2015;25(10):1145-58. DMZAMNX RU https://www.ncbi.nlm.nih.gov/pubmed/26118988 DM68M0G DI DM68M0G DM68M0G DN Peptide analog 6 DM68M0G MI TT23XQV DM68M0G MN PD-1-PD-L1 interaction (PD-1/PD-L1 PPI) DM68M0G MT DTT DM68M0G MA Inhibitor DM68M0G RN A patent review on PD-1/PD-L1 antagonists: small molecules, peptides, and macrocycles (2015-2018).Expert Opin Ther Pat. 2018 Sep;28(9):665-678. DM68M0G RU https://www.ncbi.nlm.nih.gov/pubmed/30107136 DMMSTNA DI DMMSTNA DMMSTNA DN Peptide analog 60 DMMSTNA MI TTQAJF1 DMMSTNA MN Cathepsin G (CTSG) DMMSTNA MT DTT DMMSTNA MA Inhibitor DMMSTNA RN Neutrophil elastase inhibitors: a patent review and potential applications for inflammatory lung diseases (2010 - 2014).Expert Opin Ther Pat. 2015;25(10):1145-58. DMMSTNA RU https://www.ncbi.nlm.nih.gov/pubmed/26118988 DMMSTNA DI DMMSTNA DMMSTNA DN Peptide analog 60 DMMSTNA MI TTPLTSQ DMMSTNA MN Neutrophil elastase (NE) DMMSTNA MT DTT DMMSTNA MA Inhibitor DMMSTNA RN Neutrophil elastase inhibitors: a patent review and potential applications for inflammatory lung diseases (2010 - 2014).Expert Opin Ther Pat. 2015;25(10):1145-58. DMMSTNA RU https://www.ncbi.nlm.nih.gov/pubmed/26118988 DM45JMT DI DM45JMT DM45JMT DN Peptide analog 61 DM45JMT MI TTQAJF1 DM45JMT MN Cathepsin G (CTSG) DM45JMT MT DTT DM45JMT MA Inhibitor DM45JMT RN Neutrophil elastase inhibitors: a patent review and potential applications for inflammatory lung diseases (2010 - 2014).Expert Opin Ther Pat. 2015;25(10):1145-58. DM45JMT RU https://www.ncbi.nlm.nih.gov/pubmed/26118988 DM45JMT DI DM45JMT DM45JMT DN Peptide analog 61 DM45JMT MI TTPLTSQ DM45JMT MN Neutrophil elastase (NE) DM45JMT MT DTT DM45JMT MA Inhibitor DM45JMT RN Neutrophil elastase inhibitors: a patent review and potential applications for inflammatory lung diseases (2010 - 2014).Expert Opin Ther Pat. 2015;25(10):1145-58. DM45JMT RU https://www.ncbi.nlm.nih.gov/pubmed/26118988 DM28NK0 DI DM28NK0 DM28NK0 DN Peptide analog 62 DM28NK0 MI TTQAJF1 DM28NK0 MN Cathepsin G (CTSG) DM28NK0 MT DTT DM28NK0 MA Inhibitor DM28NK0 RN Neutrophil elastase inhibitors: a patent review and potential applications for inflammatory lung diseases (2010 - 2014).Expert Opin Ther Pat. 2015;25(10):1145-58. DM28NK0 RU https://www.ncbi.nlm.nih.gov/pubmed/26118988 DM28NK0 DI DM28NK0 DM28NK0 DN Peptide analog 62 DM28NK0 MI TTPLTSQ DM28NK0 MN Neutrophil elastase (NE) DM28NK0 MT DTT DM28NK0 MA Inhibitor DM28NK0 RN Neutrophil elastase inhibitors: a patent review and potential applications for inflammatory lung diseases (2010 - 2014).Expert Opin Ther Pat. 2015;25(10):1145-58. DM28NK0 RU https://www.ncbi.nlm.nih.gov/pubmed/26118988 DMGC7NW DI DMGC7NW DMGC7NW DN Peptide analog 63 DMGC7NW MI TTPLTSQ DMGC7NW MN Neutrophil elastase (NE) DMGC7NW MT DTT DMGC7NW MA Inhibitor DMGC7NW RN Neutrophil elastase inhibitors: a patent review and potential applications for inflammatory lung diseases (2010 - 2014).Expert Opin Ther Pat. 2015;25(10):1145-58. DMGC7NW RU https://www.ncbi.nlm.nih.gov/pubmed/26118988 DM1G2J5 DI DM1G2J5 DM1G2J5 DN Peptide analog 64 DM1G2J5 MI TTPLTSQ DM1G2J5 MN Neutrophil elastase (NE) DM1G2J5 MT DTT DM1G2J5 MA Inhibitor DM1G2J5 RN Neutrophil elastase inhibitors: a patent review and potential applications for inflammatory lung diseases (2010 - 2014).Expert Opin Ther Pat. 2015;25(10):1145-58. DM1G2J5 RU https://www.ncbi.nlm.nih.gov/pubmed/26118988 DMAJLM1 DI DMAJLM1 DMAJLM1 DN Peptide analog 65 DMAJLM1 MI TTPLTSQ DMAJLM1 MN Neutrophil elastase (NE) DMAJLM1 MT DTT DMAJLM1 MA Inhibitor DMAJLM1 RN Neutrophil elastase inhibitors: a patent review and potential applications for inflammatory lung diseases (2010 - 2014).Expert Opin Ther Pat. 2015;25(10):1145-58. DMAJLM1 RU https://www.ncbi.nlm.nih.gov/pubmed/26118988 DMW502M DI DMW502M DMW502M DN Peptide analog 66 DMW502M MI TTPLTSQ DMW502M MN Neutrophil elastase (NE) DMW502M MT DTT DMW502M MA Inhibitor DMW502M RN Neutrophil elastase inhibitors: a patent review and potential applications for inflammatory lung diseases (2010 - 2014).Expert Opin Ther Pat. 2015;25(10):1145-58. DMW502M RU https://www.ncbi.nlm.nih.gov/pubmed/26118988 DMJ8QTX DI DMJ8QTX DMJ8QTX DN Peptide analog 67 DMJ8QTX MI TTPLTSQ DMJ8QTX MN Neutrophil elastase (NE) DMJ8QTX MT DTT DMJ8QTX MA Inhibitor DMJ8QTX RN Neutrophil elastase inhibitors: a patent review and potential applications for inflammatory lung diseases (2010 - 2014).Expert Opin Ther Pat. 2015;25(10):1145-58. DMJ8QTX RU https://www.ncbi.nlm.nih.gov/pubmed/26118988 DMFG2KT DI DMFG2KT DMFG2KT DN Peptide analog 68 DMFG2KT MI TTPLTSQ DMFG2KT MN Neutrophil elastase (NE) DMFG2KT MT DTT DMFG2KT MA Inhibitor DMFG2KT RN Neutrophil elastase inhibitors: a patent review and potential applications for inflammatory lung diseases (2010 - 2014).Expert Opin Ther Pat. 2015;25(10):1145-58. DMFG2KT RU https://www.ncbi.nlm.nih.gov/pubmed/26118988 DM2OXW3 DI DM2OXW3 DM2OXW3 DN Peptide analog 69 DM2OXW3 MI TTPLTSQ DM2OXW3 MN Neutrophil elastase (NE) DM2OXW3 MT DTT DM2OXW3 MA Inhibitor DM2OXW3 RN Neutrophil elastase inhibitors: a patent review and potential applications for inflammatory lung diseases (2010 - 2014).Expert Opin Ther Pat. 2015;25(10):1145-58. DM2OXW3 RU https://www.ncbi.nlm.nih.gov/pubmed/26118988 DMKYOLV DI DMKYOLV DMKYOLV DN Peptide analog 7 DMKYOLV MI TTH8FZW DMKYOLV MN Signal transducer and activator of transcription 3 (STAT3) DMKYOLV MT DTT DMKYOLV MA Inhibitor DMKYOLV RN A STAT inhibitor patent review: progress since 2011.Expert Opin Ther Pat. 2015;25(12):1397-421. DMKYOLV RU https://www.ncbi.nlm.nih.gov/pubmed/26394986 DMN43Q5 DI DMN43Q5 DMN43Q5 DN Peptide analog 70 DMN43Q5 MI TTQAJF1 DMN43Q5 MN Cathepsin G (CTSG) DMN43Q5 MT DTT DMN43Q5 MA Inhibitor DMN43Q5 RN Neutrophil elastase inhibitors: a patent review and potential applications for inflammatory lung diseases (2010 - 2014).Expert Opin Ther Pat. 2015;25(10):1145-58. DMN43Q5 RU https://www.ncbi.nlm.nih.gov/pubmed/26118988 DMN43Q5 DI DMN43Q5 DMN43Q5 DN Peptide analog 70 DMN43Q5 MI TTPLTSQ DMN43Q5 MN Neutrophil elastase (NE) DMN43Q5 MT DTT DMN43Q5 MA Inhibitor DMN43Q5 RN Neutrophil elastase inhibitors: a patent review and potential applications for inflammatory lung diseases (2010 - 2014).Expert Opin Ther Pat. 2015;25(10):1145-58. DMN43Q5 RU https://www.ncbi.nlm.nih.gov/pubmed/26118988 DMSEKZG DI DMSEKZG DMSEKZG DN Peptide analog 71 DMSEKZG MI TTQR74A DMSEKZG MN Proteinase activated receptor 2 (PAR2) DMSEKZG MT DTT DMSEKZG MA Agonist DMSEKZG RN Protease activated receptor 2 (PAR2) modulators: a patent review (2010-2015).Expert Opin Ther Pat. 2016;26(4):471-83. DMSEKZG RU https://www.ncbi.nlm.nih.gov/pubmed/26936077 DMXU71M DI DMXU71M DMXU71M DN Peptide analog 72 DMXU71M MI TTQR74A DMXU71M MN Proteinase activated receptor 2 (PAR2) DMXU71M MT DTT DMXU71M MA Agonist DMXU71M RN Protease activated receptor 2 (PAR2) modulators: a patent review (2010-2015).Expert Opin Ther Pat. 2016;26(4):471-83. DMXU71M RU https://www.ncbi.nlm.nih.gov/pubmed/26936077 DMFG7A8 DI DMFG7A8 DMFG7A8 DN Peptide analog 8 DMFG7A8 MI TTN7R6K DMFG7A8 MN Signal transducer and activator of transcription 1 (STAT1) DMFG7A8 MT DTT DMFG7A8 MA Inhibitor DMFG7A8 RN A STAT inhibitor patent review: progress since 2011.Expert Opin Ther Pat. 2015;25(12):1397-421. DMFG7A8 RU https://www.ncbi.nlm.nih.gov/pubmed/26394986 DM953EV DI DM953EV DM953EV DN Peptide analog 9 DM953EV MI TTSJMN8 DM953EV MN Immunoproteasome complex (IP) DM953EV MT DTT DM953EV MA Inhibitor DM953EV RN A patent review of immunoproteasome inhibitors.Expert Opin Ther Pat. 2018 Jul;28(7):517-540. DM953EV RU https://www.ncbi.nlm.nih.gov/pubmed/29865878 DMMP9N7 DI DMMP9N7 DMMP9N7 DN Peptidomimetic analog 1 DMMP9N7 MI TTH8FZW DMMP9N7 MN Signal transducer and activator of transcription 3 (STAT3) DMMP9N7 MT DTT DMMP9N7 MA Inhibitor DMMP9N7 RN A STAT inhibitor patent review: progress since 2011.Expert Opin Ther Pat. 2015;25(12):1397-421. DMMP9N7 RU https://www.ncbi.nlm.nih.gov/pubmed/26394986 DMN2VZW DI DMN2VZW DMN2VZW DN Peptidomimetic analog 2 DMN2VZW MI TTH8FZW DMN2VZW MN Signal transducer and activator of transcription 3 (STAT3) DMN2VZW MT DTT DMN2VZW MA Inhibitor DMN2VZW RN A STAT inhibitor patent review: progress since 2011.Expert Opin Ther Pat. 2015;25(12):1397-421. DMN2VZW RU https://www.ncbi.nlm.nih.gov/pubmed/26394986 DMPWS9N DI DMPWS9N DMPWS9N DN Peptidomimetic analog 3 DMPWS9N MI TTH8FZW DMPWS9N MN Signal transducer and activator of transcription 3 (STAT3) DMPWS9N MT DTT DMPWS9N MA Inhibitor DMPWS9N RN A STAT inhibitor patent review: progress since 2011.Expert Opin Ther Pat. 2015;25(12):1397-421. DMPWS9N RU https://www.ncbi.nlm.nih.gov/pubmed/26394986 DM9Q0JS DI DM9Q0JS DM9Q0JS DN Peptidomimetic analog 4 DM9Q0JS MI TTH8FZW DM9Q0JS MN Signal transducer and activator of transcription 3 (STAT3) DM9Q0JS MT DTT DM9Q0JS MA Inhibitor DM9Q0JS RN A STAT inhibitor patent review: progress since 2011.Expert Opin Ther Pat. 2015;25(12):1397-421. DM9Q0JS RU https://www.ncbi.nlm.nih.gov/pubmed/26394986 DMF0DE2 DI DMF0DE2 DMF0DE2 DN Peptidomimetic analog 5 DMF0DE2 MI TTN7R6K DMF0DE2 MN Signal transducer and activator of transcription 1 (STAT1) DMF0DE2 MT DTT DMF0DE2 MA Inhibitor DMF0DE2 RN A STAT inhibitor patent review: progress since 2011.Expert Opin Ther Pat. 2015;25(12):1397-421. DMF0DE2 RU https://www.ncbi.nlm.nih.gov/pubmed/26394986 DMF0DE2 DI DMF0DE2 DMF0DE2 DN Peptidomimetic analog 5 DMF0DE2 MI TTH8FZW DMF0DE2 MN Signal transducer and activator of transcription 3 (STAT3) DMF0DE2 MT DTT DMF0DE2 MA Inhibitor DMF0DE2 RN A STAT inhibitor patent review: progress since 2011.Expert Opin Ther Pat. 2015;25(12):1397-421. DMF0DE2 RU https://www.ncbi.nlm.nih.gov/pubmed/26394986 DMSUD5X DI DMSUD5X DMSUD5X DN Peptidomimetic analog 6 DMSUD5X MI TTQR74A DMSUD5X MN Proteinase activated receptor 2 (PAR2) DMSUD5X MT DTT DMSUD5X MA Agonist DMSUD5X RN Protease activated receptor 2 (PAR2) modulators: a patent review (2010-2015).Expert Opin Ther Pat. 2016;26(4):471-83. DMSUD5X RU https://www.ncbi.nlm.nih.gov/pubmed/26936077 DM15TMH DI DM15TMH DM15TMH DN Peptidomimetic analog 7 DM15TMH MI TTUX68I DM15TMH MN Hypoxia-inducible factor 1 (HIF-1) DM15TMH MT DTT DM15TMH MA Inhibitor DM15TMH RN Hypoxia-inducible factor (HIF) inhibitors: a patent survey (2011-2015).Expert Opin Ther Pat. 2016;26(3):309-22. DM15TMH RU https://www.ncbi.nlm.nih.gov/pubmed/26882240 DM0PBJT DI DM0PBJT DM0PBJT DN Phenoxypiperidine derivative 1 DM0PBJT MI TT9JNIC DM0PBJT MN Histamine H3 receptor (H3R) DM0PBJT MT DTT DM0PBJT RN Progress in the development of histamine H3 receptor antagonists/inverse agonists: a patent review (2013-2017).Expert Opin Ther Pat. 2018 Mar;28(3):175-196. DM0PBJT RU https://www.ncbi.nlm.nih.gov/pubmed/29334795 DMC5G8P DI DMC5G8P DMC5G8P DN Phenoxypiperidine derivative 2 DMC5G8P MI TT9JNIC DMC5G8P MN Histamine H3 receptor (H3R) DMC5G8P MT DTT DMC5G8P RN Progress in the development of histamine H3 receptor antagonists/inverse agonists: a patent review (2013-2017).Expert Opin Ther Pat. 2018 Mar;28(3):175-196. DMC5G8P RU https://www.ncbi.nlm.nih.gov/pubmed/29334795 DMVYP8K DI DMVYP8K DMVYP8K DN Phenylalanine derivative 1 DMVYP8K MI TT36ETB DMVYP8K MN Cathepsin L (CTSL) DMVYP8K MT DTT DMVYP8K MA Inhibitor DMVYP8K RN Cathepsin B and L inhibitors: a patent review (2010 - present).Expert Opin Ther Pat. 2017 Jun;27(6):643-656. DMVYP8K RU https://www.ncbi.nlm.nih.gov/pubmed/27998201 DMVYP8K DI DMVYP8K DMVYP8K DN Phenylalanine derivative 1 DMVYP8K MI TTUMQVO DMVYP8K MN Cathepsin S (CTSS) DMVYP8K MT DTT DMVYP8K MA Inhibitor DMVYP8K RN Cathepsin B and L inhibitors: a patent review (2010 - present).Expert Opin Ther Pat. 2017 Jun;27(6):643-656. DMVYP8K RU https://www.ncbi.nlm.nih.gov/pubmed/27998201 DMEO9QB DI DMEO9QB DMEO9QB DN Phenylate derivative 1 DMEO9QB MI TT23XQV DMEO9QB MN PD-1-PD-L1 interaction (PD-1/PD-L1 PPI) DMEO9QB MT DTT DMEO9QB MA Inhibitor DMEO9QB RN A patent review on PD-1/PD-L1 antagonists: small molecules, peptides, and macrocycles (2015-2018).Expert Opin Ther Pat. 2018 Sep;28(9):665-678. DMEO9QB RU https://www.ncbi.nlm.nih.gov/pubmed/30107136 DMG0ZSY DI DMG0ZSY DMG0ZSY DN Phenylate derivative 2 DMG0ZSY MI TT23XQV DMG0ZSY MN PD-1-PD-L1 interaction (PD-1/PD-L1 PPI) DMG0ZSY MT DTT DMG0ZSY MA Inhibitor DMG0ZSY RN A patent review on PD-1/PD-L1 antagonists: small molecules, peptides, and macrocycles (2015-2018).Expert Opin Ther Pat. 2018 Sep;28(9):665-678. DMG0ZSY RU https://www.ncbi.nlm.nih.gov/pubmed/30107136 DM1BIY4 DI DM1BIY4 DM1BIY4 DN Phenylmethanesulfonamide derivative 1 DM1BIY4 MI TTJOW1I DM1BIY4 MN Mannoside acetylglucosaminyltransferase 2 (MGAT2) DM1BIY4 MT DTT DM1BIY4 MA Inhibitor DM1BIY4 RN Acyltransferase inhibitors: a patent review (2010-present).Expert Opin Ther Pat. 2015 Feb;25(2):145-58. DM1BIY4 RU https://www.ncbi.nlm.nih.gov/pubmed/25470667 DMTEJRB DI DMTEJRB DMTEJRB DN Phenylpropionic acid derivative 1 DMTEJRB MI TTZMAO3 DMTEJRB MN Peroxisome proliferator-activated receptor gamma (PPAR-gamma) DMTEJRB MT DTT DMTEJRB MA Agonist DMTEJRB RN PPAR ligands and their therapeutic applications: a patent review (2008 - 2014).Expert Opin Ther Pat. 2015 Feb;25(2):175-91. DMTEJRB RU https://www.ncbi.nlm.nih.gov/pubmed/25416646 DMVCKZT DI DMVCKZT DMVCKZT DN Phenylpropylamine derivative 1 DMVCKZT MI TT5TPI6 DMVCKZT MN Opioid receptor sigma 1 (OPRS1) DMVCKZT MT DTT DMVCKZT MA Ligand DMVCKZT RN Are sigma modulators an effective opportunity for cancer treatment A patent overview (1996-2016).Expert Opin Ther Pat. 2017 May;27(5):565-578. DMVCKZT RU https://www.ncbi.nlm.nih.gov/pubmed/28051882 DMTDIA6 DI DMTDIA6 DMTDIA6 DN Phenylpropylamine derivative 2 DMTDIA6 MI TT5TPI6 DMTDIA6 MN Opioid receptor sigma 1 (OPRS1) DMTDIA6 MT DTT DMTDIA6 MA Ligand DMTDIA6 RN Are sigma modulators an effective opportunity for cancer treatment A patent overview (1996-2016).Expert Opin Ther Pat. 2017 May;27(5):565-578. DMTDIA6 RU https://www.ncbi.nlm.nih.gov/pubmed/28051882 DMH3FUR DI DMH3FUR DMH3FUR DN Phenylpropylamine derivative 3 DMH3FUR MI TT5TPI6 DMH3FUR MN Opioid receptor sigma 1 (OPRS1) DMH3FUR MT DTT DMH3FUR MA Ligand DMH3FUR RN Are sigma modulators an effective opportunity for cancer treatment A patent overview (1996-2016).Expert Opin Ther Pat. 2017 May;27(5):565-578. DMH3FUR RU https://www.ncbi.nlm.nih.gov/pubmed/28051882 DM0R653 DI DM0R653 DM0R653 DN Phenylpropylamine derivative 4 DM0R653 MI TT5TPI6 DM0R653 MN Opioid receptor sigma 1 (OPRS1) DM0R653 MT DTT DM0R653 MA Ligand DM0R653 RN Are sigma modulators an effective opportunity for cancer treatment A patent overview (1996-2016).Expert Opin Ther Pat. 2017 May;27(5):565-578. DM0R653 RU https://www.ncbi.nlm.nih.gov/pubmed/28051882 DMU0S2W DI DMU0S2W DMU0S2W DN Phenylpropylamine derivative 5 DMU0S2W MI TT5TPI6 DMU0S2W MN Opioid receptor sigma 1 (OPRS1) DMU0S2W MT DTT DMU0S2W MA Ligand DMU0S2W RN Are sigma modulators an effective opportunity for cancer treatment A patent overview (1996-2016).Expert Opin Ther Pat. 2017 May;27(5):565-578. DMU0S2W RU https://www.ncbi.nlm.nih.gov/pubmed/28051882 DMLSWKR DI DMLSWKR DMLSWKR DN Phenylpurine acetamide analog 1 DMLSWKR MI TTPTXIN DMLSWKR MN Translocator protein (TSPO) DMLSWKR MT DTT DMLSWKR MA Ligand DMLSWKR RN Translocator protein (TSPO) ligands for the diagnosis or treatment of neurodegenerative diseases: a patent review (2010-2015; part 1).Expert Opin Ther Pat. 2016 Nov;26(11):1325-1351. DMLSWKR RU https://www.ncbi.nlm.nih.gov/pubmed/27607364 DMMGBLC DI DMMGBLC DMMGBLC DN Phenylpurine acetamide analog 2 DMMGBLC MI TTPTXIN DMMGBLC MN Translocator protein (TSPO) DMMGBLC MT DTT DMMGBLC MA Ligand DMMGBLC RN Translocator protein (TSPO) ligands for the diagnosis or treatment of neurodegenerative diseases: a patent review (2010-2015; part 1).Expert Opin Ther Pat. 2016 Nov;26(11):1325-1351. DMMGBLC RU https://www.ncbi.nlm.nih.gov/pubmed/27607364 DMVHLQM DI DMVHLQM DMVHLQM DN Phenylpyridine derivative 1 DMVHLQM MI TT1LVF2 DMVHLQM MN Cyclin-dependent kinase 9 (CDK9) DMVHLQM MT DTT DMVHLQM MA Inhibitor DMVHLQM RN Cyclin-dependent kinase inhibitors for cancer therapy: a patent review (2009 - 2014).Expert Opin Ther Pat. 2015;25(9):953-70. DMVHLQM RU https://www.ncbi.nlm.nih.gov/pubmed/26161698 DMTRPE6 DI DMTRPE6 DMTRPE6 DN Phenylpyridine derivative 2 DMTRPE6 MI TT1LVF2 DMTRPE6 MN Cyclin-dependent kinase 9 (CDK9) DMTRPE6 MT DTT DMTRPE6 MA Inhibitor DMTRPE6 RN Cyclin-dependent kinase inhibitors for cancer therapy: a patent review (2009 - 2014).Expert Opin Ther Pat. 2015;25(9):953-70. DMTRPE6 RU https://www.ncbi.nlm.nih.gov/pubmed/26161698 DMDT5JI DI DMDT5JI DMDT5JI DN Phenylpyridine derivative 3 DMDT5JI MI TTQVOEI DMDT5JI MN Angiotensin II receptor type-2 (AGTR2) DMDT5JI MT DTT DMDT5JI MA Agonist DMDT5JI RN PPAR ligands and their therapeutic applications: a patent review (2008 - 2014).Expert Opin Ther Pat. 2015 Feb;25(2):175-91. DMDT5JI RU https://www.ncbi.nlm.nih.gov/pubmed/25416646 DMDT5JI DI DMDT5JI DMDT5JI DN Phenylpyridine derivative 3 DMDT5JI MI TTZMAO3 DMDT5JI MN Peroxisome proliferator-activated receptor gamma (PPAR-gamma) DMDT5JI MT DTT DMDT5JI MA Agonist DMDT5JI RN PPAR ligands and their therapeutic applications: a patent review (2008 - 2014).Expert Opin Ther Pat. 2015 Feb;25(2):175-91. DMDT5JI RU https://www.ncbi.nlm.nih.gov/pubmed/25416646 DMPAI5C DI DMPAI5C DMPAI5C DN Phenylpyrrolidinone derivative 1 DMPAI5C MI TT5OU0D DMPAI5C MN PRKR-like endoplasmic reticulum kinase (PERK) DMPAI5C MT DTT DMPAI5C MA Inhibitor DMPAI5C RN Protein kinase R(PKR)-like endoplasmic reticulum kinase (PERK) inhibitors: a patent review (2010-2015).Expert Opin Ther Pat. 2017 Jan;27(1):37-48. DMPAI5C RU https://www.ncbi.nlm.nih.gov/pubmed/27646439 DMF3NCO DI DMF3NCO DMF3NCO DN Phenylpyrrolidinone derivative 2 DMF3NCO MI TT5OU0D DMF3NCO MN PRKR-like endoplasmic reticulum kinase (PERK) DMF3NCO MT DTT DMF3NCO MA Inhibitor DMF3NCO RN Protein kinase R(PKR)-like endoplasmic reticulum kinase (PERK) inhibitors: a patent review (2010-2015).Expert Opin Ther Pat. 2017 Jan;27(1):37-48. DMF3NCO RU https://www.ncbi.nlm.nih.gov/pubmed/27646439 DMPZKQN DI DMPZKQN DMPZKQN DN Phenylpyrrolidinone derivative 3 DMPZKQN MI TT5OU0D DMPZKQN MN PRKR-like endoplasmic reticulum kinase (PERK) DMPZKQN MT DTT DMPZKQN MA Inhibitor DMPZKQN RN Protein kinase R(PKR)-like endoplasmic reticulum kinase (PERK) inhibitors: a patent review (2010-2015).Expert Opin Ther Pat. 2017 Jan;27(1):37-48. DMPZKQN RU https://www.ncbi.nlm.nih.gov/pubmed/27646439 DMSX47Q DI DMSX47Q DMSX47Q DN Phenylpyrrolidinone derivative 4 DMSX47Q MI TT5OU0D DMSX47Q MN PRKR-like endoplasmic reticulum kinase (PERK) DMSX47Q MT DTT DMSX47Q MA Inhibitor DMSX47Q RN Protein kinase R(PKR)-like endoplasmic reticulum kinase (PERK) inhibitors: a patent review (2010-2015).Expert Opin Ther Pat. 2017 Jan;27(1):37-48. DMSX47Q RU https://www.ncbi.nlm.nih.gov/pubmed/27646439 DMZSTLH DI DMZSTLH DMZSTLH DN Phenylpyrrolidinone derivative 5 DMZSTLH MI TT5OU0D DMZSTLH MN PRKR-like endoplasmic reticulum kinase (PERK) DMZSTLH MT DTT DMZSTLH MA Inhibitor DMZSTLH RN Protein kinase R(PKR)-like endoplasmic reticulum kinase (PERK) inhibitors: a patent review (2010-2015).Expert Opin Ther Pat. 2017 Jan;27(1):37-48. DMZSTLH RU https://www.ncbi.nlm.nih.gov/pubmed/27646439 DM9NOP3 DI DM9NOP3 DM9NOP3 DN Phenylsulfonyl derivative 1 DM9NOP3 MI TT9JNIC DM9NOP3 MN Histamine H3 receptor (H3R) DM9NOP3 MT DTT DM9NOP3 MA Inhibitor DM9NOP3 RN Progress in the development of histamine H3 receptor antagonists/inverse agonists: a patent review (2013-2017).Expert Opin Ther Pat. 2018 Mar;28(3):175-196. DM9NOP3 RU https://www.ncbi.nlm.nih.gov/pubmed/29334795 DM63128 DI DM63128 DM63128 DN Phenylsulfonyl derivative 2 DM63128 MI TT9JNIC DM63128 MN Histamine H3 receptor (H3R) DM63128 MT DTT DM63128 MA Inhibitor DM63128 RN Progress in the development of histamine H3 receptor antagonists/inverse agonists: a patent review (2013-2017).Expert Opin Ther Pat. 2018 Mar;28(3):175-196. DM63128 RU https://www.ncbi.nlm.nih.gov/pubmed/29334795 DME6FLN DI DME6FLN DME6FLN DN Phenylsulfonyl derivative 3 DME6FLN MI TT9JNIC DME6FLN MN Histamine H3 receptor (H3R) DME6FLN MT DTT DME6FLN MA Inhibitor DME6FLN RN Progress in the development of histamine H3 receptor antagonists/inverse agonists: a patent review (2013-2017).Expert Opin Ther Pat. 2018 Mar;28(3):175-196. DME6FLN RU https://www.ncbi.nlm.nih.gov/pubmed/29334795 DM1HYW4 DI DM1HYW4 DM1HYW4 DN Phenylsulfonyl derivative 4 DM1HYW4 MI TT9JNIC DM1HYW4 MN Histamine H3 receptor (H3R) DM1HYW4 MT DTT DM1HYW4 MA Inhibitor DM1HYW4 RN Progress in the development of histamine H3 receptor antagonists/inverse agonists: a patent review (2013-2017).Expert Opin Ther Pat. 2018 Mar;28(3):175-196. DM1HYW4 RU https://www.ncbi.nlm.nih.gov/pubmed/29334795 DMTHXUC DI DMTHXUC DMTHXUC DN Phenylthioacetate derivative 1 DMTHXUC MI TTA592U DMTHXUC MN Urate anion exchanger 1 (URAT1) DMTHXUC MT DTT DMTHXUC MA Inhibitor DMTHXUC RN Urate transporter URAT1 inhibitors: a patent review (2012 - 2015).Expert Opin Ther Pat. 2016 Jul 30:1-10. DMTHXUC RU https://www.ncbi.nlm.nih.gov/pubmed/27414413 DMZPHN5 DI DMZPHN5 DMZPHN5 DN Phthalazine derivative 1 DMZPHN5 MI TTEBCY8 DMZPHN5 MN Poly [ADP-ribose] polymerase (PARP) DMZPHN5 MT DTT DMZPHN5 MA Inhibitor DMZPHN5 RN PARP inhibitors as antitumor agents: a patent update (2013-2015).Expert Opin Ther Pat. 2017 Mar;27(3):363-382. DMZPHN5 RU https://www.ncbi.nlm.nih.gov/pubmed/27841036 DMODTSC DI DMODTSC DMODTSC DN Phthalazine derivative 2 DMODTSC MI TTEBCY8 DMODTSC MN Poly [ADP-ribose] polymerase (PARP) DMODTSC MT DTT DMODTSC MA Inhibitor DMODTSC RN PARP inhibitors as antitumor agents: a patent update (2013-2015).Expert Opin Ther Pat. 2017 Mar;27(3):363-382. DMODTSC RU https://www.ncbi.nlm.nih.gov/pubmed/27841036 DMA1OEF DI DMA1OEF DMA1OEF DN Phthalazine derivative 3 DMA1OEF MI TTVDSZ0 DMA1OEF MN Poly [ADP-ribose] polymerase 1 (PARP1) DMA1OEF MT DTT DMA1OEF MA Inhibitor DMA1OEF RN PARP inhibitors as antitumor agents: a patent update (2013-2015).Expert Opin Ther Pat. 2017 Mar;27(3):363-382. DMA1OEF RU https://www.ncbi.nlm.nih.gov/pubmed/27841036 DMD2R1H DI DMD2R1H DMD2R1H DN Phthalazine ketone derivative 1 DMD2R1H MI TTVDSZ0 DMD2R1H MN Poly [ADP-ribose] polymerase 1 (PARP1) DMD2R1H MT DTT DMD2R1H MA Inhibitor DMD2R1H RN PARP inhibitors as antitumor agents: a patent update (2013-2015).Expert Opin Ther Pat. 2017 Mar;27(3):363-382. DMD2R1H RU https://www.ncbi.nlm.nih.gov/pubmed/27841036 DM07C1I DI DM07C1I DM07C1I DN Phthalazine ketone derivative 2 DM07C1I MI TTVDSZ0 DM07C1I MN Poly [ADP-ribose] polymerase 1 (PARP1) DM07C1I MT DTT DM07C1I MA Inhibitor DM07C1I RN PARP inhibitors as antitumor agents: a patent update (2013-2015).Expert Opin Ther Pat. 2017 Mar;27(3):363-382. DM07C1I RU https://www.ncbi.nlm.nih.gov/pubmed/27841036 DMIWY93 DI DMIWY93 DMIWY93 DN Phthalazine ketone derivative 3 DMIWY93 MI TTVDSZ0 DMIWY93 MN Poly [ADP-ribose] polymerase 1 (PARP1) DMIWY93 MT DTT DMIWY93 MA Inhibitor DMIWY93 RN PARP inhibitors as antitumor agents: a patent update (2013-2015).Expert Opin Ther Pat. 2017 Mar;27(3):363-382. DMIWY93 RU https://www.ncbi.nlm.nih.gov/pubmed/27841036 DMNA941 DI DMNA941 DMNA941 DN Phthalazinone derivative 1 DMNA941 MI TTYLQ8V DMNA941 MN Prostaglandin E synthase (PTGES) DMNA941 MT DTT DMNA941 MA Inhibitor DMNA941 RN Microsomal prostaglandin E2 synthase-1 inhibitors: a patent review.Expert Opin Ther Pat. 2017 Sep;27(9):1047-1059. DMNA941 RU https://www.ncbi.nlm.nih.gov/pubmed/28627961 DM5H3R8 DI DM5H3R8 DM5H3R8 DN PhyllanthoidA DM5H3R8 MI TT3WG5C DM5H3R8 MN Monoamine oxidase type A (MAO-A) DM5H3R8 MT DTT DM5H3R8 MA Inhibitor DM5H3R8 RN Novel monoamine oxidase inhibitors: a patent review (2012 - 2014).Expert Opin Ther Pat. 2015 Jan;25(1):91-110. DM5H3R8 RU https://www.ncbi.nlm.nih.gov/pubmed/25399762 DMM9F8D DI DMM9F8D DMM9F8D DN Phytocannabinoid/aminoalkylindole derivative 1 DMM9F8D MI TT6OEDT DMM9F8D MN Cannabinoid receptor 1 (CB1) DMM9F8D MT DTT DMM9F8D RN Cannabinoid receptor 2 (CB2) agonists and antagonists: a patent update.Expert Opin Ther Pat. 2016 Jul;26(7):843-56. DMM9F8D RU https://www.ncbi.nlm.nih.gov/pubmed/27215781 DMM9F8D DI DMM9F8D DMM9F8D DN Phytocannabinoid/aminoalkylindole derivative 1 DMM9F8D MI TTMSFAW DMM9F8D MN Cannabinoid receptor 2 (CB2) DMM9F8D MT DTT DMM9F8D RN Cannabinoid receptor 2 (CB2) agonists and antagonists: a patent update.Expert Opin Ther Pat. 2016 Jul;26(7):843-56. DMM9F8D RU https://www.ncbi.nlm.nih.gov/pubmed/27215781 DMOXJ7Q DI DMOXJ7Q DMOXJ7Q DN Phytocannabinoid/aminoalkylindole derivative 2 DMOXJ7Q MI TT6OEDT DMOXJ7Q MN Cannabinoid receptor 1 (CB1) DMOXJ7Q MT DTT DMOXJ7Q RN Cannabinoid receptor 2 (CB2) agonists and antagonists: a patent update.Expert Opin Ther Pat. 2016 Jul;26(7):843-56. DMOXJ7Q RU https://www.ncbi.nlm.nih.gov/pubmed/27215781 DMOXJ7Q DI DMOXJ7Q DMOXJ7Q DN Phytocannabinoid/aminoalkylindole derivative 2 DMOXJ7Q MI TTMSFAW DMOXJ7Q MN Cannabinoid receptor 2 (CB2) DMOXJ7Q MT DTT DMOXJ7Q RN Cannabinoid receptor 2 (CB2) agonists and antagonists: a patent update.Expert Opin Ther Pat. 2016 Jul;26(7):843-56. DMOXJ7Q RU https://www.ncbi.nlm.nih.gov/pubmed/27215781 DMUP4DX DI DMUP4DX DMUP4DX DN Picolinamido propanoic acid derivative 1 DMUP4DX MI TT9O6WS DMUP4DX MN Glucagon receptor (GCGR) DMUP4DX MT DTT DMUP4DX MA Antagonist DMUP4DX RN Small molecule glucagon receptor antagonists: a patent review (2011 - 2014).Expert Opin Ther Pat. 2015 Jul;25(7):819-30. DMUP4DX RU https://www.ncbi.nlm.nih.gov/pubmed/25828189 DMR74ET DI DMR74ET DMR74ET DN Picolinamido propanoic acid derivative 2 DMR74ET MI TT9O6WS DMR74ET MN Glucagon receptor (GCGR) DMR74ET MT DTT DMR74ET MA Antagonist DMR74ET RN Small molecule glucagon receptor antagonists: a patent review (2011 - 2014).Expert Opin Ther Pat. 2015 Jul;25(7):819-30. DMR74ET RU https://www.ncbi.nlm.nih.gov/pubmed/25828189 DMP1RV5 DI DMP1RV5 DMP1RV5 DN Picolinamido propanoic acid derivative 3 DMP1RV5 MI TT9O6WS DMP1RV5 MN Glucagon receptor (GCGR) DMP1RV5 MT DTT DMP1RV5 MA Antagonist DMP1RV5 RN Small molecule glucagon receptor antagonists: a patent review (2011 - 2014).Expert Opin Ther Pat. 2015 Jul;25(7):819-30. DMP1RV5 RU https://www.ncbi.nlm.nih.gov/pubmed/25828189 DMCIXD4 DI DMCIXD4 DMCIXD4 DN Piperazine carbamate/urea derivative 1 DMCIXD4 MI TT9JNIC DMCIXD4 MN Histamine H3 receptor (H3R) DMCIXD4 MT DTT DMCIXD4 MA Ligand DMCIXD4 RN Progress in the development of histamine H3 receptor antagonists/inverse agonists: a patent review (2013-2017).Expert Opin Ther Pat. 2018 Mar;28(3):175-196. DMCIXD4 RU https://www.ncbi.nlm.nih.gov/pubmed/29334795 DMCG6BE DI DMCG6BE DMCG6BE DN Piperazine carbamate/urea derivative 2 DMCG6BE MI TT9JNIC DMCG6BE MN Histamine H3 receptor (H3R) DMCG6BE MT DTT DMCG6BE MA Ligand DMCG6BE RN Progress in the development of histamine H3 receptor antagonists/inverse agonists: a patent review (2013-2017).Expert Opin Ther Pat. 2018 Mar;28(3):175-196. DMCG6BE RU https://www.ncbi.nlm.nih.gov/pubmed/29334795 DM2R468 DI DM2R468 DM2R468 DN Piperazine carbamate/urea derivative 3 DM2R468 MI TT9JNIC DM2R468 MN Histamine H3 receptor (H3R) DM2R468 MT DTT DM2R468 MA Ligand DM2R468 RN Progress in the development of histamine H3 receptor antagonists/inverse agonists: a patent review (2013-2017).Expert Opin Ther Pat. 2018 Mar;28(3):175-196. DM2R468 RU https://www.ncbi.nlm.nih.gov/pubmed/29334795 DM75J4T DI DM75J4T DM75J4T DN Piperazine carbamate/urea derivative 4 DM75J4T MI TT9JNIC DM75J4T MN Histamine H3 receptor (H3R) DM75J4T MT DTT DM75J4T MA Ligand DM75J4T RN Progress in the development of histamine H3 receptor antagonists/inverse agonists: a patent review (2013-2017).Expert Opin Ther Pat. 2018 Mar;28(3):175-196. DM75J4T RU https://www.ncbi.nlm.nih.gov/pubmed/29334795 DMJ80IZ DI DMJ80IZ DMJ80IZ DN Piperazine carbamate/urea derivative 5 DMJ80IZ MI TT9JNIC DMJ80IZ MN Histamine H3 receptor (H3R) DMJ80IZ MT DTT DMJ80IZ MA Ligand DMJ80IZ RN Progress in the development of histamine H3 receptor antagonists/inverse agonists: a patent review (2013-2017).Expert Opin Ther Pat. 2018 Mar;28(3):175-196. DMJ80IZ RU https://www.ncbi.nlm.nih.gov/pubmed/29334795 DMZEPU3 DI DMZEPU3 DMZEPU3 DN Piperazine carbamate/urea derivative 6 DMZEPU3 MI TT9JNIC DMZEPU3 MN Histamine H3 receptor (H3R) DMZEPU3 MT DTT DMZEPU3 MA Ligand DMZEPU3 RN Progress in the development of histamine H3 receptor antagonists/inverse agonists: a patent review (2013-2017).Expert Opin Ther Pat. 2018 Mar;28(3):175-196. DMZEPU3 RU https://www.ncbi.nlm.nih.gov/pubmed/29334795 DM067UC DI DM067UC DM067UC DN Piperazine carbamate/urea derivative 7 DM067UC MI TT9JNIC DM067UC MN Histamine H3 receptor (H3R) DM067UC MT DTT DM067UC MA Ligand DM067UC RN Progress in the development of histamine H3 receptor antagonists/inverse agonists: a patent review (2013-2017).Expert Opin Ther Pat. 2018 Mar;28(3):175-196. DM067UC RU https://www.ncbi.nlm.nih.gov/pubmed/29334795 DMZSYU4 DI DMZSYU4 DMZSYU4 DN Piperazine carbamic compound 1 DMZSYU4 MI TTDP1UC DMZSYU4 MN Fatty acid amide hydrolase (FAAH) DMZSYU4 MT DTT DMZSYU4 MA Inhibitor DMZSYU4 RN A patent review of Monoacylglycerol Lipase (MAGL) inhibitors (2013-2017).Expert Opin Ther Pat. 2017 Dec;27(12):1341-1351. DMZSYU4 RU https://www.ncbi.nlm.nih.gov/pubmed/29053063 DMZSYU4 DI DMZSYU4 DMZSYU4 DN Piperazine carbamic compound 1 DMZSYU4 MI TTSINOV DMZSYU4 MN Monoacylglycerol lipase ABHD6 (ABHD6) DMZSYU4 MT DTT DMZSYU4 MA Inhibitor DMZSYU4 RN A patent review of Monoacylglycerol Lipase (MAGL) inhibitors (2013-2017).Expert Opin Ther Pat. 2017 Dec;27(12):1341-1351. DMZSYU4 RU https://www.ncbi.nlm.nih.gov/pubmed/29053063 DMZSYU4 DI DMZSYU4 DMZSYU4 DN Piperazine carbamic compound 1 DMZSYU4 MI TTZ963I DMZSYU4 MN Monoglyceride lipase (MAGL) DMZSYU4 MT DTT DMZSYU4 MA Inhibitor DMZSYU4 RN A patent review of Monoacylglycerol Lipase (MAGL) inhibitors (2013-2017).Expert Opin Ther Pat. 2017 Dec;27(12):1341-1351. DMZSYU4 RU https://www.ncbi.nlm.nih.gov/pubmed/29053063 DMMQ0ZO DI DMMQ0ZO DMMQ0ZO DN Piperazine carbamic compound 2 DMMQ0ZO MI TTDP1UC DMMQ0ZO MN Fatty acid amide hydrolase (FAAH) DMMQ0ZO MT DTT DMMQ0ZO MA Inhibitor DMMQ0ZO RN A patent review of Monoacylglycerol Lipase (MAGL) inhibitors (2013-2017).Expert Opin Ther Pat. 2017 Dec;27(12):1341-1351. DMMQ0ZO RU https://www.ncbi.nlm.nih.gov/pubmed/29053063 DMMQ0ZO DI DMMQ0ZO DMMQ0ZO DN Piperazine carbamic compound 2 DMMQ0ZO MI TTSINOV DMMQ0ZO MN Monoacylglycerol lipase ABHD6 (ABHD6) DMMQ0ZO MT DTT DMMQ0ZO MA Inhibitor DMMQ0ZO RN A patent review of Monoacylglycerol Lipase (MAGL) inhibitors (2013-2017).Expert Opin Ther Pat. 2017 Dec;27(12):1341-1351. DMMQ0ZO RU https://www.ncbi.nlm.nih.gov/pubmed/29053063 DMMQ0ZO DI DMMQ0ZO DMMQ0ZO DN Piperazine carbamic compound 2 DMMQ0ZO MI TTZ963I DMMQ0ZO MN Monoglyceride lipase (MAGL) DMMQ0ZO MT DTT DMMQ0ZO MA Inhibitor DMMQ0ZO RN A patent review of Monoacylglycerol Lipase (MAGL) inhibitors (2013-2017).Expert Opin Ther Pat. 2017 Dec;27(12):1341-1351. DMMQ0ZO RU https://www.ncbi.nlm.nih.gov/pubmed/29053063 DM8IU1G DI DM8IU1G DM8IU1G DN Piperazine carbamic compound 3 DM8IU1G MI TTZ963I DM8IU1G MN Monoglyceride lipase (MAGL) DM8IU1G MT DTT DM8IU1G MA Inhibitor DM8IU1G RN A patent review of Monoacylglycerol Lipase (MAGL) inhibitors (2013-2017).Expert Opin Ther Pat. 2017 Dec;27(12):1341-1351. DM8IU1G RU https://www.ncbi.nlm.nih.gov/pubmed/29053063 DMKZUO4 DI DMKZUO4 DMKZUO4 DN Piperazine carbamic compound 4 DMKZUO4 MI TTSINOV DMKZUO4 MN Monoacylglycerol lipase ABHD6 (ABHD6) DMKZUO4 MT DTT DMKZUO4 MA Inhibitor DMKZUO4 RN A patent review of Monoacylglycerol Lipase (MAGL) inhibitors (2013-2017).Expert Opin Ther Pat. 2017 Dec;27(12):1341-1351. DMKZUO4 RU https://www.ncbi.nlm.nih.gov/pubmed/29053063 DMKZUO4 DI DMKZUO4 DMKZUO4 DN Piperazine carbamic compound 4 DMKZUO4 MI TTZ963I DMKZUO4 MN Monoglyceride lipase (MAGL) DMKZUO4 MT DTT DMKZUO4 MA Inhibitor DMKZUO4 RN A patent review of Monoacylglycerol Lipase (MAGL) inhibitors (2013-2017).Expert Opin Ther Pat. 2017 Dec;27(12):1341-1351. DMKZUO4 RU https://www.ncbi.nlm.nih.gov/pubmed/29053063 DMXH65Z DI DMXH65Z DMXH65Z DN Piperazine carbamic compound 5 DMXH65Z MI TTSINOV DMXH65Z MN Monoacylglycerol lipase ABHD6 (ABHD6) DMXH65Z MT DTT DMXH65Z MA Inhibitor DMXH65Z RN A patent review of Monoacylglycerol Lipase (MAGL) inhibitors (2013-2017).Expert Opin Ther Pat. 2017 Dec;27(12):1341-1351. DMXH65Z RU https://www.ncbi.nlm.nih.gov/pubmed/29053063 DMXH65Z DI DMXH65Z DMXH65Z DN Piperazine carbamic compound 5 DMXH65Z MI TTZ963I DMXH65Z MN Monoglyceride lipase (MAGL) DMXH65Z MT DTT DMXH65Z MA Inhibitor DMXH65Z RN A patent review of Monoacylglycerol Lipase (MAGL) inhibitors (2013-2017).Expert Opin Ther Pat. 2017 Dec;27(12):1341-1351. DMXH65Z RU https://www.ncbi.nlm.nih.gov/pubmed/29053063 DMJ7F1Q DI DMJ7F1Q DMJ7F1Q DN Piperazine derivative 1 DMJ7F1Q MI TT6OEDT DMJ7F1Q MN Cannabinoid receptor 1 (CB1) DMJ7F1Q MT DTT DMJ7F1Q MA Antagonist DMJ7F1Q RN A comprehensive patents review on cannabinoid 1 receptor antagonists as antiobesity agents. Expert Opin Ther Pat. 2015 Oct;25(10):1093-116. DMJ7F1Q RU https://pubmed.ncbi.nlm.nih.gov/26161824 DM4JZ2T DI DM4JZ2T DM4JZ2T DN Piperazine derivative 2 DM4JZ2T MI TT6OEDT DM4JZ2T MN Cannabinoid receptor 1 (CB1) DM4JZ2T MT DTT DM4JZ2T MA Antagonist DM4JZ2T RN A comprehensive patents review on cannabinoid 1 receptor antagonists as antiobesity agents. Expert Opin Ther Pat. 2015 Oct;25(10):1093-116. DM4JZ2T RU https://pubmed.ncbi.nlm.nih.gov/26161824 DM8MZR6 DI DM8MZR6 DM8MZR6 DN Piperazine derivative 3 DM8MZR6 MI TTJQOD7 DM8MZR6 MN 5-HT 2A receptor (HTR2A) DM8MZR6 MT DTT DM8MZR6 MA Antagonist DM8MZR6 RN Novel serotonin receptor 2 (5-HT2R) agonists and antagonists: a patent review (2004-2014).Expert Opin Ther Pat. 2016;26(1):89-106. DM8MZR6 RU https://www.ncbi.nlm.nih.gov/pubmed/26609882 DM2XGNY DI DM2XGNY DM2XGNY DN Piperazine derivative 4 DM2XGNY MI TTJQOD7 DM2XGNY MN 5-HT 2A receptor (HTR2A) DM2XGNY MT DTT DM2XGNY MA Antagonist DM2XGNY RN Novel serotonin receptor 2 (5-HT2R) agonists and antagonists: a patent review (2004-2014).Expert Opin Ther Pat. 2016;26(1):89-106. DM2XGNY RU https://www.ncbi.nlm.nih.gov/pubmed/26609882 DMDFUBH DI DMDFUBH DMDFUBH DN Piperazine derivative 5 DMDFUBH MI TTQR74A DMDFUBH MN Proteinase activated receptor 2 (PAR2) DMDFUBH MT DTT DMDFUBH MA Antagonist DMDFUBH RN Protease activated receptor 2 (PAR2) modulators: a patent review (2010-2015).Expert Opin Ther Pat. 2016;26(4):471-83. DMDFUBH RU https://www.ncbi.nlm.nih.gov/pubmed/26936077 DMDL3A5 DI DMDL3A5 DMDL3A5 DN Piperazine derivative 6 DMDL3A5 MI TT473XN DMDL3A5 MN P2X purinoceptor 7 (P2RX7) DMDL3A5 MT DTT DMDL3A5 MA Antagonist DMDL3A5 RN P2X7 receptor antagonists: a patent review (2010-2015).Expert Opin Ther Pat. 2017 Mar;27(3):257-267. DMDL3A5 RU https://www.ncbi.nlm.nih.gov/pubmed/27724045 DM9Y4ZV DI DM9Y4ZV DM9Y4ZV DN Piperazine derivative 7 DM9Y4ZV MI TT5TPI6 DM9Y4ZV MN Opioid receptor sigma 1 (OPRS1) DM9Y4ZV MT DTT DM9Y4ZV MA Ligand DM9Y4ZV RN Are sigma modulators an effective opportunity for cancer treatment A patent overview (1996-2016).Expert Opin Ther Pat. 2017 May;27(5):565-578. DM9Y4ZV RU https://www.ncbi.nlm.nih.gov/pubmed/28051882 DM9Y4ZV DI DM9Y4ZV DM9Y4ZV DN Piperazine derivative 7 DM9Y4ZV MI TT9NXW4 DM9Y4ZV MN Sigma intracellular receptor 2 (TMEM97) DM9Y4ZV MT DTT DM9Y4ZV MA Ligand DM9Y4ZV RN Are sigma modulators an effective opportunity for cancer treatment A patent overview (1996-2016).Expert Opin Ther Pat. 2017 May;27(5):565-578. DM9Y4ZV RU https://www.ncbi.nlm.nih.gov/pubmed/28051882 DM1XUVB DI DM1XUVB DM1XUVB DN Piperazine derivative 8 DM1XUVB MI TTSCIM2 DM1XUVB MN Extracellular lysophospholipase D (E-NPP2) DM1XUVB MT DTT DM1XUVB RN Autotaxin inhibitors: a patent review (2012-2016).Expert Opin Ther Pat. 2017 Jul;27(7):815-829. DM1XUVB RU https://www.ncbi.nlm.nih.gov/pubmed/28447479 DMEWAQ9 DI DMEWAQ9 DMEWAQ9 DN Piperazine urea derivative 1 DMEWAQ9 MI TTDP1UC DMEWAQ9 MN Fatty acid amide hydrolase (FAAH) DMEWAQ9 MT DTT DMEWAQ9 MA Inhibitor DMEWAQ9 RN Fatty acid amide hydrolase inhibitors: a patent review (2009-2014).Expert Opin Ther Pat. 2015;25(11):1247-66. DMEWAQ9 RU https://www.ncbi.nlm.nih.gov/pubmed/26413912 DM5OCM7 DI DM5OCM7 DM5OCM7 DN Piperazine urea derivative 2 DM5OCM7 MI TTGX13H DM5OCM7 MN Fatty-acid amide hydrolase 1 (FAAH1) DM5OCM7 MT DTT DM5OCM7 MA Inhibitor DM5OCM7 RN Fatty acid amide hydrolase inhibitors: a patent review (2009-2014).Expert Opin Ther Pat. 2015;25(11):1247-66. DM5OCM7 RU https://www.ncbi.nlm.nih.gov/pubmed/26413912 DMNAJWQ DI DMNAJWQ DMNAJWQ DN Piperazine urea derivative 3 DMNAJWQ MI TTQR74A DMNAJWQ MN Proteinase activated receptor 2 (PAR2) DMNAJWQ MT DTT DMNAJWQ MA Antagonist DMNAJWQ RN Protease activated receptor 2 (PAR2) modulators: a patent review (2010-2015).Expert Opin Ther Pat. 2016;26(4):471-83. DMNAJWQ RU https://www.ncbi.nlm.nih.gov/pubmed/26936077 DM3K7IM DI DM3K7IM DM3K7IM DN Piperazine urea derivative 4 DM3K7IM MI TTQR74A DM3K7IM MN Proteinase activated receptor 2 (PAR2) DM3K7IM MT DTT DM3K7IM MA Antagonist DM3K7IM RN Protease activated receptor 2 (PAR2) modulators: a patent review (2010-2015).Expert Opin Ther Pat. 2016;26(4):471-83. DM3K7IM RU https://www.ncbi.nlm.nih.gov/pubmed/26936077 DM7WOD9 DI DM7WOD9 DM7WOD9 DN Piperazinyl methyl quinazolinone derivative 1 DM7WOD9 MI TT9NXW4 DM7WOD9 MN Sigma intracellular receptor 2 (TMEM97) DM7WOD9 MT DTT DM7WOD9 MA Ligand DM7WOD9 RN The sigma-2 (-2) receptor: a review of recent patent applications: 2013-2018.Expert Opin Ther Pat. 2018 Sep;28(9):655-663. DM7WOD9 RU https://www.ncbi.nlm.nih.gov/pubmed/30185082 DM913KS DI DM913KS DM913KS DN Piperazinyl methyl quinazolinone derivative 2 DM913KS MI TT9NXW4 DM913KS MN Sigma intracellular receptor 2 (TMEM97) DM913KS MT DTT DM913KS MA Ligand DM913KS RN The sigma-2 (-2) receptor: a review of recent patent applications: 2013-2018.Expert Opin Ther Pat. 2018 Sep;28(9):655-663. DM913KS RU https://www.ncbi.nlm.nih.gov/pubmed/30185082 DMYH4AZ DI DMYH4AZ DMYH4AZ DN Piperazinyl methyl quinazolinone derivative 3 DMYH4AZ MI TT9NXW4 DMYH4AZ MN Sigma intracellular receptor 2 (TMEM97) DMYH4AZ MT DTT DMYH4AZ MA Ligand DMYH4AZ RN The sigma-2 (-2) receptor: a review of recent patent applications: 2013-2018.Expert Opin Ther Pat. 2018 Sep;28(9):655-663. DMYH4AZ RU https://www.ncbi.nlm.nih.gov/pubmed/30185082 DM3LKTE DI DM3LKTE DM3LKTE DN Piperazinyl norbenzomorphane compound 1 DM3LKTE MI TT9NXW4 DM3LKTE MN Sigma intracellular receptor 2 (TMEM97) DM3LKTE MT DTT DM3LKTE MA Ligand DM3LKTE RN The sigma-2 (-2) receptor: a review of recent patent applications: 2013-2018.Expert Opin Ther Pat. 2018 Sep;28(9):655-663. DM3LKTE RU https://www.ncbi.nlm.nih.gov/pubmed/30185082 DMD2CX1 DI DMD2CX1 DMD2CX1 DN Piperazinyl norbenzomorphane compound 2 DMD2CX1 MI TT9NXW4 DMD2CX1 MN Sigma intracellular receptor 2 (TMEM97) DMD2CX1 MT DTT DMD2CX1 MA Ligand DMD2CX1 RN The sigma-2 (-2) receptor: a review of recent patent applications: 2013-2018.Expert Opin Ther Pat. 2018 Sep;28(9):655-663. DMD2CX1 RU https://www.ncbi.nlm.nih.gov/pubmed/30185082 DMZYJKG DI DMZYJKG DMZYJKG DN Piperazinyl norbenzomorphane compound 3 DMZYJKG MI TT9NXW4 DMZYJKG MN Sigma intracellular receptor 2 (TMEM97) DMZYJKG MT DTT DMZYJKG MA Ligand DMZYJKG RN The sigma-2 (-2) receptor: a review of recent patent applications: 2013-2018.Expert Opin Ther Pat. 2018 Sep;28(9):655-663. DMZYJKG RU https://www.ncbi.nlm.nih.gov/pubmed/30185082 DMRSCJ7 DI DMRSCJ7 DMRSCJ7 DN Piperazinyl norbenzomorphane compound 4 DMRSCJ7 MI TT9NXW4 DMRSCJ7 MN Sigma intracellular receptor 2 (TMEM97) DMRSCJ7 MT DTT DMRSCJ7 MA Ligand DMRSCJ7 RN The sigma-2 (-2) receptor: a review of recent patent applications: 2013-2018.Expert Opin Ther Pat. 2018 Sep;28(9):655-663. DMRSCJ7 RU https://www.ncbi.nlm.nih.gov/pubmed/30185082 DMY8QIG DI DMY8QIG DMY8QIG DN Piperidine carboxamide derivative 1 DMY8QIG MI TTYLQ8V DMY8QIG MN Prostaglandin E synthase (PTGES) DMY8QIG MT DTT DMY8QIG MA Inhibitor DMY8QIG RN Microsomal prostaglandin E2 synthase-1 inhibitors: a patent review.Expert Opin Ther Pat. 2017 Sep;27(9):1047-1059. DMY8QIG RU https://www.ncbi.nlm.nih.gov/pubmed/28627961 DMHN5KW DI DMHN5KW DMHN5KW DN Piperidine derivative 1 DMHN5KW MI TTTIBOJ DMHN5KW MN Histamine H1 receptor (H1R) DMHN5KW MT DTT DMHN5KW RN Progress in the development of histamine H3 receptor antagonists/inverse agonists: a patent review (2013-2017).Expert Opin Ther Pat. 2018 Mar;28(3):175-196. DMHN5KW RU https://www.ncbi.nlm.nih.gov/pubmed/29334795 DMHN5KW DI DMHN5KW DMHN5KW DN Piperidine derivative 1 DMHN5KW MI TT9JNIC DMHN5KW MN Histamine H3 receptor (H3R) DMHN5KW MT DTT DMHN5KW RN Progress in the development of histamine H3 receptor antagonists/inverse agonists: a patent review (2013-2017).Expert Opin Ther Pat. 2018 Mar;28(3):175-196. DMHN5KW RU https://www.ncbi.nlm.nih.gov/pubmed/29334795 DMHN5KW DI DMHN5KW DMHN5KW DN Piperidine derivative 1 DMHN5KW MI TT3ROYC DMHN5KW MN Serotonin transporter (SERT) DMHN5KW MT DTT DMHN5KW RN Progress in the development of histamine H3 receptor antagonists/inverse agonists: a patent review (2013-2017).Expert Opin Ther Pat. 2018 Mar;28(3):175-196. DMHN5KW RU https://www.ncbi.nlm.nih.gov/pubmed/29334795 DMHXMB4 DI DMHXMB4 DMHXMB4 DN Piperidine derivative 2 DMHXMB4 MI TTQR74A DMHXMB4 MN Proteinase activated receptor 2 (PAR2) DMHXMB4 MT DTT DMHXMB4 MA Antagonist DMHXMB4 RN Protease activated receptor 2 (PAR2) modulators: a patent review (2010-2015).Expert Opin Ther Pat. 2016;26(4):471-83. DMHXMB4 RU https://www.ncbi.nlm.nih.gov/pubmed/26936077 DM80XRM DI DM80XRM DM80XRM DN Piperidine derivative 3 DM80XRM MI TTQR74A DM80XRM MN Proteinase activated receptor 2 (PAR2) DM80XRM MT DTT DM80XRM MA Antagonist DM80XRM RN Protease activated receptor 2 (PAR2) modulators: a patent review (2010-2015).Expert Opin Ther Pat. 2016;26(4):471-83. DM80XRM RU https://www.ncbi.nlm.nih.gov/pubmed/26936077 DM6C5DR DI DM6C5DR DM6C5DR DN Piperidine derivative 4 DM6C5DR MI TT5TPI6 DM6C5DR MN Opioid receptor sigma 1 (OPRS1) DM6C5DR MT DTT DM6C5DR MA Ligand DM6C5DR RN Are sigma modulators an effective opportunity for cancer treatment A patent overview (1996-2016).Expert Opin Ther Pat. 2017 May;27(5):565-578. DM6C5DR RU https://www.ncbi.nlm.nih.gov/pubmed/28051882 DMQ0VK4 DI DMQ0VK4 DMQ0VK4 DN Piperidine derivative 5 DMQ0VK4 MI TT5TPI6 DMQ0VK4 MN Opioid receptor sigma 1 (OPRS1) DMQ0VK4 MT DTT DMQ0VK4 MA Ligand DMQ0VK4 RN Are sigma modulators an effective opportunity for cancer treatment A patent overview (1996-2016).Expert Opin Ther Pat. 2017 May;27(5):565-578. DMQ0VK4 RU https://www.ncbi.nlm.nih.gov/pubmed/28051882 DMQ0VK4 DI DMQ0VK4 DMQ0VK4 DN Piperidine derivative 5 DMQ0VK4 MI TT9NXW4 DMQ0VK4 MN Sigma intracellular receptor 2 (TMEM97) DMQ0VK4 MT DTT DMQ0VK4 MA Ligand DMQ0VK4 RN Are sigma modulators an effective opportunity for cancer treatment A patent overview (1996-2016).Expert Opin Ther Pat. 2017 May;27(5):565-578. DMQ0VK4 RU https://www.ncbi.nlm.nih.gov/pubmed/28051882 DM0GCTY DI DM0GCTY DM0GCTY DN Piperidine derivative 6 DM0GCTY MI TT5TPI6 DM0GCTY MN Opioid receptor sigma 1 (OPRS1) DM0GCTY MT DTT DM0GCTY MA Ligand DM0GCTY RN Are sigma modulators an effective opportunity for cancer treatment A patent overview (1996-2016).Expert Opin Ther Pat. 2017 May;27(5):565-578. DM0GCTY RU https://www.ncbi.nlm.nih.gov/pubmed/28051882 DM0GCTY DI DM0GCTY DM0GCTY DN Piperidine derivative 6 DM0GCTY MI TT9NXW4 DM0GCTY MN Sigma intracellular receptor 2 (TMEM97) DM0GCTY MT DTT DM0GCTY MA Ligand DM0GCTY RN Are sigma modulators an effective opportunity for cancer treatment A patent overview (1996-2016).Expert Opin Ther Pat. 2017 May;27(5):565-578. DM0GCTY RU https://www.ncbi.nlm.nih.gov/pubmed/28051882 DMAM50X DI DMAM50X DMAM50X DN Piperidinone derivative 1 DMAM50X MI TT473XN DMAM50X MN P2X purinoceptor 7 (P2RX7) DMAM50X MT DTT DMAM50X MA Antagonist DMAM50X RN P2X7 receptor antagonists: a patent review (2010-2015).Expert Opin Ther Pat. 2017 Mar;27(3):257-267. DMAM50X RU https://www.ncbi.nlm.nih.gov/pubmed/27724045 DMWAYXP DI DMWAYXP DMWAYXP DN Piperidinyl pyrazole derivative 1 DMWAYXP MI TTTJZ4M DMWAYXP MN Prolylcarboxypeptidase (PRCP) DMWAYXP MT DTT DMWAYXP MA Inhibitor DMWAYXP RN Prolylcarboxypeptidase (PrCP) inhibitors and the therapeutic uses thereof: a patent review.Expert Opin Ther Pat. 2017 Oct;27(10):1077-1088. DMWAYXP RU https://www.ncbi.nlm.nih.gov/pubmed/28699813 DM21S5G DI DM21S5G DM21S5G DN Piperidinyl pyrazole derivative 2 DM21S5G MI TTTJZ4M DM21S5G MN Prolylcarboxypeptidase (PRCP) DM21S5G MT DTT DM21S5G MA Inhibitor DM21S5G RN Prolylcarboxypeptidase (PrCP) inhibitors and the therapeutic uses thereof: a patent review.Expert Opin Ther Pat. 2017 Oct;27(10):1077-1088. DM21S5G RU https://www.ncbi.nlm.nih.gov/pubmed/28699813 DMX2V0W DI DMX2V0W DMX2V0W DN Piperidinyl pyrazole derivative 3 DMX2V0W MI TTTJZ4M DMX2V0W MN Prolylcarboxypeptidase (PRCP) DMX2V0W MT DTT DMX2V0W MA Inhibitor DMX2V0W RN Prolylcarboxypeptidase (PrCP) inhibitors and the therapeutic uses thereof: a patent review.Expert Opin Ther Pat. 2017 Oct;27(10):1077-1088. DMX2V0W RU https://www.ncbi.nlm.nih.gov/pubmed/28699813 DMS8NFJ DI DMS8NFJ DMS8NFJ DN Piperidinyl pyrazole derivative 4 DMS8NFJ MI TTTJZ4M DMS8NFJ MN Prolylcarboxypeptidase (PRCP) DMS8NFJ MT DTT DMS8NFJ MA Inhibitor DMS8NFJ RN Prolylcarboxypeptidase (PrCP) inhibitors and the therapeutic uses thereof: a patent review.Expert Opin Ther Pat. 2017 Oct;27(10):1077-1088. DMS8NFJ RU https://www.ncbi.nlm.nih.gov/pubmed/28699813 DMTSX7J DI DMTSX7J DMTSX7J DN Piperidinyl triazole derivative 1 DMTSX7J MI TTTJZ4M DMTSX7J MN Prolylcarboxypeptidase (PRCP) DMTSX7J MT DTT DMTSX7J MA Inhibitor DMTSX7J RN Prolylcarboxypeptidase (PrCP) inhibitors and the therapeutic uses thereof: a patent review.Expert Opin Ther Pat. 2017 Oct;27(10):1077-1088. DMTSX7J RU https://www.ncbi.nlm.nih.gov/pubmed/28699813 DM2FZPE DI DM2FZPE DM2FZPE DN Piperidinyl triazole derivative 2 DM2FZPE MI TTTJZ4M DM2FZPE MN Prolylcarboxypeptidase (PRCP) DM2FZPE MT DTT DM2FZPE MA Inhibitor DM2FZPE RN Prolylcarboxypeptidase (PrCP) inhibitors and the therapeutic uses thereof: a patent review.Expert Opin Ther Pat. 2017 Oct;27(10):1077-1088. DM2FZPE RU https://www.ncbi.nlm.nih.gov/pubmed/28699813 DM0J2TE DI DM0J2TE DM0J2TE DN Piperidinyl triazole derivative 3 DM0J2TE MI TTTJZ4M DM0J2TE MN Prolylcarboxypeptidase (PRCP) DM0J2TE MT DTT DM0J2TE MA Inhibitor DM0J2TE RN Prolylcarboxypeptidase (PrCP) inhibitors and the therapeutic uses thereof: a patent review.Expert Opin Ther Pat. 2017 Oct;27(10):1077-1088. DM0J2TE RU https://www.ncbi.nlm.nih.gov/pubmed/28699813 DMOQJMU DI DMOQJMU DMOQJMU DN Piperidinyl triazole derivative 4 DMOQJMU MI TTTJZ4M DMOQJMU MN Prolylcarboxypeptidase (PRCP) DMOQJMU MT DTT DMOQJMU MA Inhibitor DMOQJMU RN Prolylcarboxypeptidase (PrCP) inhibitors and the therapeutic uses thereof: a patent review.Expert Opin Ther Pat. 2017 Oct;27(10):1077-1088. DMOQJMU RU https://www.ncbi.nlm.nih.gov/pubmed/28699813 DM4QVD0 DI DM4QVD0 DM4QVD0 DN Piperidinyl triazole derivative 5 DM4QVD0 MI TTTJZ4M DM4QVD0 MN Prolylcarboxypeptidase (PRCP) DM4QVD0 MT DTT DM4QVD0 MA Inhibitor DM4QVD0 RN Prolylcarboxypeptidase (PrCP) inhibitors and the therapeutic uses thereof: a patent review.Expert Opin Ther Pat. 2017 Oct;27(10):1077-1088. DM4QVD0 RU https://www.ncbi.nlm.nih.gov/pubmed/28699813 DMG5HI1 DI DMG5HI1 DMG5HI1 DN Piperidinyl triazole derivative 6 DMG5HI1 MI TTTJZ4M DMG5HI1 MN Prolylcarboxypeptidase (PRCP) DMG5HI1 MT DTT DMG5HI1 MA Inhibitor DMG5HI1 RN Prolylcarboxypeptidase (PrCP) inhibitors and the therapeutic uses thereof: a patent review.Expert Opin Ther Pat. 2017 Oct;27(10):1077-1088. DMG5HI1 RU https://www.ncbi.nlm.nih.gov/pubmed/28699813 DME26SY DI DME26SY DME26SY DN Piperonal DME26SY MI TTGP7BY DME26SY MN Monoamine oxidase type B (MAO-B) DME26SY MT DTT DME26SY MA Inhibitor DME26SY RN Novel monoamine oxidase inhibitors: a patent review (2012 - 2014).Expert Opin Ther Pat. 2015 Jan;25(1):91-110. DME26SY RU https://www.ncbi.nlm.nih.gov/pubmed/25399762 DMFZ9Q3 DI DMFZ9Q3 DMFZ9Q3 DN Pitavastatin derivative 1 DMFZ9Q3 MI TTPADOQ DMFZ9Q3 MN HMG-CoA reductase (HMGCR) DMFZ9Q3 MT DTT DMFZ9Q3 MA Inhibitor DMFZ9Q3 RN HMG-CoA Reductase inhibitors: an updated review of patents of novel compounds and formulations (2011-2015).Expert Opin Ther Pat. 2016 Nov;26(11):1257-1272. DMFZ9Q3 RU https://www.ncbi.nlm.nih.gov/pubmed/27537201 DM8OYI4 DI DM8OYI4 DM8OYI4 DN Platinum IV complexe 1 DM8OYI4 MI TTN7R6K DM8OYI4 MN Signal transducer and activator of transcription 1 (STAT1) DM8OYI4 MT DTT DM8OYI4 MA Inhibitor DM8OYI4 RN A STAT inhibitor patent review: progress since 2011.Expert Opin Ther Pat. 2015;25(12):1397-421. DM8OYI4 RU https://www.ncbi.nlm.nih.gov/pubmed/26394986 DM8OYI4 DI DM8OYI4 DM8OYI4 DN Platinum IV complexe 1 DM8OYI4 MI TTH8FZW DM8OYI4 MN Signal transducer and activator of transcription 3 (STAT3) DM8OYI4 MT DTT DM8OYI4 MA Inhibitor DM8OYI4 RN A STAT inhibitor patent review: progress since 2011.Expert Opin Ther Pat. 2015;25(12):1397-421. DM8OYI4 RU https://www.ncbi.nlm.nih.gov/pubmed/26394986 DM8OYI4 DI DM8OYI4 DM8OYI4 DN Platinum IV complexe 1 DM8OYI4 MI TTLRFIH DM8OYI4 MN Signal transducer and activator of transcription 5 (STAT5) DM8OYI4 MT DTT DM8OYI4 MA Inhibitor DM8OYI4 RN A STAT inhibitor patent review: progress since 2011.Expert Opin Ther Pat. 2015;25(12):1397-421. DM8OYI4 RU https://www.ncbi.nlm.nih.gov/pubmed/26394986 DMRXKJZ DI DMRXKJZ DMRXKJZ DN PMID25399719-Compound-17 DMRXKJZ MI TTG5QB7 DMRXKJZ MN Calpain-2 (CAPN2) DMRXKJZ MT DTT DMRXKJZ MA Inhibitor DMRXKJZ RN An updated patent review of calpain inhibitors (2012 - 2014).Expert Opin Ther Pat. 2015 Jan;25(1):17-31. DMRXKJZ RU https://www.ncbi.nlm.nih.gov/pubmed/25399719 DMRXKJZ DI DMRXKJZ DMRXKJZ DN PMID25399719-Compound-17 DMRXKJZ MI TTDZN01 DMRXKJZ MN Cathepsin K (CTSK) DMRXKJZ MT DTT DMRXKJZ MA Inhibitor DMRXKJZ RN An updated patent review of calpain inhibitors (2012 - 2014).Expert Opin Ther Pat. 2015 Jan;25(1):17-31. DMRXKJZ RU https://www.ncbi.nlm.nih.gov/pubmed/25399719 DMRXKJZ DI DMRXKJZ DMRXKJZ DN PMID25399719-Compound-17 DMRXKJZ MI TT36ETB DMRXKJZ MN Cathepsin L (CTSL) DMRXKJZ MT DTT DMRXKJZ MA Inhibitor DMRXKJZ RN An updated patent review of calpain inhibitors (2012 - 2014).Expert Opin Ther Pat. 2015 Jan;25(1):17-31. DMRXKJZ RU https://www.ncbi.nlm.nih.gov/pubmed/25399719 DMRXKJZ DI DMRXKJZ DMRXKJZ DN PMID25399719-Compound-17 DMRXKJZ MI TTUMQVO DMRXKJZ MN Cathepsin S (CTSS) DMRXKJZ MT DTT DMRXKJZ MA Inhibitor DMRXKJZ RN An updated patent review of calpain inhibitors (2012 - 2014).Expert Opin Ther Pat. 2015 Jan;25(1):17-31. DMRXKJZ RU https://www.ncbi.nlm.nih.gov/pubmed/25399719 DM23NEX DI DM23NEX DM23NEX DN PMID25399762-Compound-Figure1-Aphanamixoid A DM23NEX MI TT3WG5C DM23NEX MN Monoamine oxidase type A (MAO-A) DM23NEX MT DTT DM23NEX MA Inhibitor DM23NEX RN Novel monoamine oxidase inhibitors: a patent review (2012 - 2014).Expert Opin Ther Pat. 2015 Jan;25(1):91-110. DM23NEX RU https://www.ncbi.nlm.nih.gov/pubmed/25399762 DMRHNOY DI DMRHNOY DMRHNOY DN PMID25399762-Compound-Figure1-Chukrasone A DMRHNOY MI TT3WG5C DMRHNOY MN Monoamine oxidase type A (MAO-A) DMRHNOY MT DTT DMRHNOY MA Inhibitor DMRHNOY RN Novel monoamine oxidase inhibitors: a patent review (2012 - 2014).Expert Opin Ther Pat. 2015 Jan;25(1):91-110. DMRHNOY RU https://www.ncbi.nlm.nih.gov/pubmed/25399762 DM0K4XE DI DM0K4XE DM0K4XE DN PMID25399762-Compound-Figure1-Chukrasone B DM0K4XE MI TT3WG5C DM0K4XE MN Monoamine oxidase type A (MAO-A) DM0K4XE MT DTT DM0K4XE MA Inhibitor DM0K4XE RN Novel monoamine oxidase inhibitors: a patent review (2012 - 2014).Expert Opin Ther Pat. 2015 Jan;25(1):91-110. DM0K4XE RU https://www.ncbi.nlm.nih.gov/pubmed/25399762 DMDX1MK DI DMDX1MK DMDX1MK DN PMID25399762-Compound-Figure1-Eryngiolide A DMDX1MK MI TT3WG5C DMDX1MK MN Monoamine oxidase type A (MAO-A) DMDX1MK MT DTT DMDX1MK MA Inhibitor DMDX1MK RN Novel monoamine oxidase inhibitors: a patent review (2012 - 2014).Expert Opin Ther Pat. 2015 Jan;25(1):91-110. DMDX1MK RU https://www.ncbi.nlm.nih.gov/pubmed/25399762 DMSYGHO DI DMSYGHO DMSYGHO DN PMID25399762-Compound-Figure1-Neonectrolide A DMSYGHO MI TT3WG5C DMSYGHO MN Monoamine oxidase type A (MAO-A) DMSYGHO MT DTT DMSYGHO MA Inhibitor DMSYGHO RN Novel monoamine oxidase inhibitors: a patent review (2012 - 2014).Expert Opin Ther Pat. 2015 Jan;25(1):91-110. DMSYGHO RU https://www.ncbi.nlm.nih.gov/pubmed/25399762 DMRIEH3 DI DMRIEH3 DMRIEH3 DN PMID25399762-Compound-Figure1-Sarcaboside A DMRIEH3 MI TT3WG5C DMRIEH3 MN Monoamine oxidase type A (MAO-A) DMRIEH3 MT DTT DMRIEH3 MA Inhibitor DMRIEH3 RN Novel monoamine oxidase inhibitors: a patent review (2012 - 2014).Expert Opin Ther Pat. 2015 Jan;25(1):91-110. DMRIEH3 RU https://www.ncbi.nlm.nih.gov/pubmed/25399762 DMDL6TG DI DMDL6TG DMDL6TG DN PMID25399762-Compound-Figure1-Sarcaboside B DMDL6TG MI TT3WG5C DMDL6TG MN Monoamine oxidase type A (MAO-A) DMDL6TG MT DTT DMDL6TG MA Inhibitor DMDL6TG RN Novel monoamine oxidase inhibitors: a patent review (2012 - 2014).Expert Opin Ther Pat. 2015 Jan;25(1):91-110. DMDL6TG RU https://www.ncbi.nlm.nih.gov/pubmed/25399762 DMG1EKV DI DMG1EKV DMG1EKV DN PMID25399762-Compound-Figure2-Artoxanthochromane DMG1EKV MI TT3WG5C DMG1EKV MN Monoamine oxidase type A (MAO-A) DMG1EKV MT DTT DMG1EKV MA Inhibitor DMG1EKV RN Novel monoamine oxidase inhibitors: a patent review (2012 - 2014).Expert Opin Ther Pat. 2015 Jan;25(1):91-110. DMG1EKV RU https://www.ncbi.nlm.nih.gov/pubmed/25399762 DMYJ0I8 DI DMYJ0I8 DMYJ0I8 DN PMID25399762-Compound-Figure2-Spirooliganone B DMYJ0I8 MI TT3WG5C DMYJ0I8 MN Monoamine oxidase type A (MAO-A) DMYJ0I8 MT DTT DMYJ0I8 MA Inhibitor DMYJ0I8 RN Novel monoamine oxidase inhibitors: a patent review (2012 - 2014).Expert Opin Ther Pat. 2015 Jan;25(1):91-110. DMYJ0I8 RU https://www.ncbi.nlm.nih.gov/pubmed/25399762 DMP5Y19 DI DMP5Y19 DMP5Y19 DN PMID25399762-Compound-Figure3-Aspeverin DMP5Y19 MI TT3WG5C DMP5Y19 MN Monoamine oxidase type A (MAO-A) DMP5Y19 MT DTT DMP5Y19 MA Inhibitor DMP5Y19 RN Novel monoamine oxidase inhibitors: a patent review (2012 - 2014).Expert Opin Ther Pat. 2015 Jan;25(1):91-110. DMP5Y19 RU https://www.ncbi.nlm.nih.gov/pubmed/25399762 DM9KTRA DI DM9KTRA DM9KTRA DN PMID25399762-Compound-Figure3-Fluevirosine A DM9KTRA MI TT3WG5C DM9KTRA MN Monoamine oxidase type A (MAO-A) DM9KTRA MT DTT DM9KTRA MA Inhibitor DM9KTRA RN Novel monoamine oxidase inhibitors: a patent review (2012 - 2014).Expert Opin Ther Pat. 2015 Jan;25(1):91-110. DM9KTRA RU https://www.ncbi.nlm.nih.gov/pubmed/25399762 DMBSP1G DI DMBSP1G DMBSP1G DN PMID25399762-Compound-Figure3-Lycojaponicumin A DMBSP1G MI TT3WG5C DMBSP1G MN Monoamine oxidase type A (MAO-A) DMBSP1G MT DTT DMBSP1G MA Inhibitor DMBSP1G RN Novel monoamine oxidase inhibitors: a patent review (2012 - 2014).Expert Opin Ther Pat. 2015 Jan;25(1):91-110. DMBSP1G RU https://www.ncbi.nlm.nih.gov/pubmed/25399762 DMKP64Z DI DMKP64Z DMKP64Z DN PMID25399762-Compound-Figure3-Lycojaponicumin B DMKP64Z MI TT3WG5C DMKP64Z MN Monoamine oxidase type A (MAO-A) DMKP64Z MT DTT DMKP64Z MA Inhibitor DMKP64Z RN Novel monoamine oxidase inhibitors: a patent review (2012 - 2014).Expert Opin Ther Pat. 2015 Jan;25(1):91-110. DMKP64Z RU https://www.ncbi.nlm.nih.gov/pubmed/25399762 DM7NUT2 DI DM7NUT2 DM7NUT2 DN PMID25399762-Compound-Figure3-Lycojaponicumin C DM7NUT2 MI TT3WG5C DM7NUT2 MN Monoamine oxidase type A (MAO-A) DM7NUT2 MT DTT DM7NUT2 MA Inhibitor DM7NUT2 RN Novel monoamine oxidase inhibitors: a patent review (2012 - 2014).Expert Opin Ther Pat. 2015 Jan;25(1):91-110. DM7NUT2 RU https://www.ncbi.nlm.nih.gov/pubmed/25399762 DMLAS7K DI DMLAS7K DMLAS7K DN PMID25399762-Compound-Table 5-8 DMLAS7K MI TT3WG5C DMLAS7K MN Monoamine oxidase type A (MAO-A) DMLAS7K MT DTT DMLAS7K MA Inhibitor DMLAS7K RN Novel monoamine oxidase inhibitors: a patent review (2012 - 2014).Expert Opin Ther Pat. 2015 Jan;25(1):91-110. DMLAS7K RU https://www.ncbi.nlm.nih.gov/pubmed/25399762 DM18FP4 DI DM18FP4 DM18FP4 DN PMID25399762-Compound-Table 5-O-methyl-M30 DM18FP4 MI TT3WG5C DM18FP4 MN Monoamine oxidase type A (MAO-A) DM18FP4 MT DTT DM18FP4 MA Inhibitor DM18FP4 RN Novel monoamine oxidase inhibitors: a patent review (2012 - 2014).Expert Opin Ther Pat. 2015 Jan;25(1):91-110. DM18FP4 RU https://www.ncbi.nlm.nih.gov/pubmed/25399762 DM4UM03 DI DM4UM03 DM4UM03 DN PMID25399762-Compound-Table 6-10 DM4UM03 MI TTNR0UQ DM4UM03 MN Lysine-specific histone demethylase 1 (LSD) DM4UM03 MT DTT DM4UM03 MA Inhibitor DM4UM03 RN Novel monoamine oxidase inhibitors: a patent review (2012 - 2014).Expert Opin Ther Pat. 2015 Jan;25(1):91-110. DM4UM03 RU https://www.ncbi.nlm.nih.gov/pubmed/25399762 DM4UM03 DI DM4UM03 DM4UM03 DN PMID25399762-Compound-Table 6-10 DM4UM03 MI TTGP7BY DM4UM03 MN Monoamine oxidase type B (MAO-B) DM4UM03 MT DTT DM4UM03 MA Inhibitor DM4UM03 RN Novel monoamine oxidase inhibitors: a patent review (2012 - 2014).Expert Opin Ther Pat. 2015 Jan;25(1):91-110. DM4UM03 RU https://www.ncbi.nlm.nih.gov/pubmed/25399762 DMYGTU2 DI DMYGTU2 DMYGTU2 DN PMID25399762-Compound-Table 6-11 DMYGTU2 MI TTNR0UQ DMYGTU2 MN Lysine-specific histone demethylase 1 (LSD) DMYGTU2 MT DTT DMYGTU2 MA Inhibitor DMYGTU2 RN Novel monoamine oxidase inhibitors: a patent review (2012 - 2014).Expert Opin Ther Pat. 2015 Jan;25(1):91-110. DMYGTU2 RU https://www.ncbi.nlm.nih.gov/pubmed/25399762 DMYGTU2 DI DMYGTU2 DMYGTU2 DN PMID25399762-Compound-Table 6-11 DMYGTU2 MI TTGP7BY DMYGTU2 MN Monoamine oxidase type B (MAO-B) DMYGTU2 MT DTT DMYGTU2 MA Inhibitor DMYGTU2 RN Novel monoamine oxidase inhibitors: a patent review (2012 - 2014).Expert Opin Ther Pat. 2015 Jan;25(1):91-110. DMYGTU2 RU https://www.ncbi.nlm.nih.gov/pubmed/25399762 DMZ07RP DI DMZ07RP DMZ07RP DN PMID25399762-Compound-Table 6-12 DMZ07RP MI TTNR0UQ DMZ07RP MN Lysine-specific histone demethylase 1 (LSD) DMZ07RP MT DTT DMZ07RP MA Inhibitor DMZ07RP RN Novel monoamine oxidase inhibitors: a patent review (2012 - 2014).Expert Opin Ther Pat. 2015 Jan;25(1):91-110. DMZ07RP RU https://www.ncbi.nlm.nih.gov/pubmed/25399762 DMZ07RP DI DMZ07RP DMZ07RP DN PMID25399762-Compound-Table 6-12 DMZ07RP MI TTGP7BY DMZ07RP MN Monoamine oxidase type B (MAO-B) DMZ07RP MT DTT DMZ07RP MA Inhibitor DMZ07RP RN Novel monoamine oxidase inhibitors: a patent review (2012 - 2014).Expert Opin Ther Pat. 2015 Jan;25(1):91-110. DMZ07RP RU https://www.ncbi.nlm.nih.gov/pubmed/25399762 DM6LR42 DI DM6LR42 DM6LR42 DN PMID25399762-Compound-Table 6-13 DM6LR42 MI TTNR0UQ DM6LR42 MN Lysine-specific histone demethylase 1 (LSD) DM6LR42 MT DTT DM6LR42 MA Inhibitor DM6LR42 RN Novel monoamine oxidase inhibitors: a patent review (2012 - 2014).Expert Opin Ther Pat. 2015 Jan;25(1):91-110. DM6LR42 RU https://www.ncbi.nlm.nih.gov/pubmed/25399762 DM6LR42 DI DM6LR42 DM6LR42 DN PMID25399762-Compound-Table 6-13 DM6LR42 MI TTGP7BY DM6LR42 MN Monoamine oxidase type B (MAO-B) DM6LR42 MT DTT DM6LR42 MA Inhibitor DM6LR42 RN Novel monoamine oxidase inhibitors: a patent review (2012 - 2014).Expert Opin Ther Pat. 2015 Jan;25(1):91-110. DM6LR42 RU https://www.ncbi.nlm.nih.gov/pubmed/25399762 DMZHB9Y DI DMZHB9Y DMZHB9Y DN PMID25399762-Compound-Table 6-14 DMZHB9Y MI TTNR0UQ DMZHB9Y MN Lysine-specific histone demethylase 1 (LSD) DMZHB9Y MT DTT DMZHB9Y MA Inhibitor DMZHB9Y RN Novel monoamine oxidase inhibitors: a patent review (2012 - 2014).Expert Opin Ther Pat. 2015 Jan;25(1):91-110. DMZHB9Y RU https://www.ncbi.nlm.nih.gov/pubmed/25399762 DMZHB9Y DI DMZHB9Y DMZHB9Y DN PMID25399762-Compound-Table 6-14 DMZHB9Y MI TTGP7BY DMZHB9Y MN Monoamine oxidase type B (MAO-B) DMZHB9Y MT DTT DMZHB9Y MA Inhibitor DMZHB9Y RN Novel monoamine oxidase inhibitors: a patent review (2012 - 2014).Expert Opin Ther Pat. 2015 Jan;25(1):91-110. DMZHB9Y RU https://www.ncbi.nlm.nih.gov/pubmed/25399762 DMCHWSF DI DMCHWSF DMCHWSF DN PMID25399762-Compound-Table 6-15 DMCHWSF MI TTNR0UQ DMCHWSF MN Lysine-specific histone demethylase 1 (LSD) DMCHWSF MT DTT DMCHWSF MA Inhibitor DMCHWSF RN Novel monoamine oxidase inhibitors: a patent review (2012 - 2014).Expert Opin Ther Pat. 2015 Jan;25(1):91-110. DMCHWSF RU https://www.ncbi.nlm.nih.gov/pubmed/25399762 DMCHWSF DI DMCHWSF DMCHWSF DN PMID25399762-Compound-Table 6-15 DMCHWSF MI TTGP7BY DMCHWSF MN Monoamine oxidase type B (MAO-B) DMCHWSF MT DTT DMCHWSF MA Inhibitor DMCHWSF RN Novel monoamine oxidase inhibitors: a patent review (2012 - 2014).Expert Opin Ther Pat. 2015 Jan;25(1):91-110. DMCHWSF RU https://www.ncbi.nlm.nih.gov/pubmed/25399762 DMDWIPG DI DMDWIPG DMDWIPG DN PMID25399762-Compound-Table 6-9 DMDWIPG MI TTNR0UQ DMDWIPG MN Lysine-specific histone demethylase 1 (LSD) DMDWIPG MT DTT DMDWIPG MA Inhibitor DMDWIPG RN Novel monoamine oxidase inhibitors: a patent review (2012 - 2014).Expert Opin Ther Pat. 2015 Jan;25(1):91-110. DMDWIPG RU https://www.ncbi.nlm.nih.gov/pubmed/25399762 DMDWIPG DI DMDWIPG DMDWIPG DN PMID25399762-Compound-Table 6-9 DMDWIPG MI TTGP7BY DMDWIPG MN Monoamine oxidase type B (MAO-B) DMDWIPG MT DTT DMDWIPG MA Inhibitor DMDWIPG RN Novel monoamine oxidase inhibitors: a patent review (2012 - 2014).Expert Opin Ther Pat. 2015 Jan;25(1):91-110. DMDWIPG RU https://www.ncbi.nlm.nih.gov/pubmed/25399762 DMSL3MB DI DMSL3MB DMSL3MB DN PMID25399762-Compound-Table 7-Vanillic acid DMSL3MB MI TTGP7BY DMSL3MB MN Monoamine oxidase type B (MAO-B) DMSL3MB MT DTT DMSL3MB MA Inhibitor DMSL3MB RN Novel monoamine oxidase inhibitors: a patent review (2012 - 2014).Expert Opin Ther Pat. 2015 Jan;25(1):91-110. DMSL3MB RU https://www.ncbi.nlm.nih.gov/pubmed/25399762 DM759MJ DI DM759MJ DM759MJ DN PMID25399762-Compound-Table 7-Vanillyl alcohol DM759MJ MI TTGP7BY DM759MJ MN Monoamine oxidase type B (MAO-B) DM759MJ MT DTT DM759MJ MA Inhibitor DM759MJ RN Novel monoamine oxidase inhibitors: a patent review (2012 - 2014).Expert Opin Ther Pat. 2015 Jan;25(1):91-110. DM759MJ RU https://www.ncbi.nlm.nih.gov/pubmed/25399762 DM4J2SM DI DM4J2SM DM4J2SM DN PMID25399762-Compound-Table 7-Veratraldehyde DM4J2SM MI TTGP7BY DM4J2SM MN Monoamine oxidase type B (MAO-B) DM4J2SM MT DTT DM4J2SM MA Inhibitor DM4J2SM RN Novel monoamine oxidase inhibitors: a patent review (2012 - 2014).Expert Opin Ther Pat. 2015 Jan;25(1):91-110. DM4J2SM RU https://www.ncbi.nlm.nih.gov/pubmed/25399762 DMMP7HX DI DMMP7HX DMMP7HX DN PMID25399762-Compound-Table1-C1 DMMP7HX MI TTGP7BY DMMP7HX MN Monoamine oxidase type B (MAO-B) DMMP7HX MT DTT DMMP7HX MA Inhibitor DMMP7HX RN Novel monoamine oxidase inhibitors: a patent review (2012 - 2014).Expert Opin Ther Pat. 2015 Jan;25(1):91-110. DMMP7HX RU https://www.ncbi.nlm.nih.gov/pubmed/25399762 DMWY5XT DI DMWY5XT DMWY5XT DN PMID25399762-Compound-Table1-C10 DMWY5XT MI TTGP7BY DMWY5XT MN Monoamine oxidase type B (MAO-B) DMWY5XT MT DTT DMWY5XT MA Inhibitor DMWY5XT RN Novel monoamine oxidase inhibitors: a patent review (2012 - 2014).Expert Opin Ther Pat. 2015 Jan;25(1):91-110. DMWY5XT RU https://www.ncbi.nlm.nih.gov/pubmed/25399762 DMVASXW DI DMVASXW DMVASXW DN PMID25399762-Compound-Table1-C11 DMVASXW MI TTGP7BY DMVASXW MN Monoamine oxidase type B (MAO-B) DMVASXW MT DTT DMVASXW MA Inhibitor DMVASXW RN Novel monoamine oxidase inhibitors: a patent review (2012 - 2014).Expert Opin Ther Pat. 2015 Jan;25(1):91-110. DMVASXW RU https://www.ncbi.nlm.nih.gov/pubmed/25399762 DMF9X6P DI DMF9X6P DMF9X6P DN PMID25399762-Compound-Table1-C12 DMF9X6P MI TTGP7BY DMF9X6P MN Monoamine oxidase type B (MAO-B) DMF9X6P MT DTT DMF9X6P MA Inhibitor DMF9X6P RN Novel monoamine oxidase inhibitors: a patent review (2012 - 2014).Expert Opin Ther Pat. 2015 Jan;25(1):91-110. DMF9X6P RU https://www.ncbi.nlm.nih.gov/pubmed/25399762 DMD80Q6 DI DMD80Q6 DMD80Q6 DN PMID25399762-Compound-Table1-C13 DMD80Q6 MI TTGP7BY DMD80Q6 MN Monoamine oxidase type B (MAO-B) DMD80Q6 MT DTT DMD80Q6 MA Inhibitor DMD80Q6 RN Novel monoamine oxidase inhibitors: a patent review (2012 - 2014).Expert Opin Ther Pat. 2015 Jan;25(1):91-110. DMD80Q6 RU https://www.ncbi.nlm.nih.gov/pubmed/25399762 DM7960M DI DM7960M DM7960M DN PMID25399762-Compound-Table1-C14 DM7960M MI TTGP7BY DM7960M MN Monoamine oxidase type B (MAO-B) DM7960M MT DTT DM7960M MA Inhibitor DM7960M RN Novel monoamine oxidase inhibitors: a patent review (2012 - 2014).Expert Opin Ther Pat. 2015 Jan;25(1):91-110. DM7960M RU https://www.ncbi.nlm.nih.gov/pubmed/25399762 DMR0P1U DI DMR0P1U DMR0P1U DN PMID25399762-Compound-Table1-C15 DMR0P1U MI TTGP7BY DMR0P1U MN Monoamine oxidase type B (MAO-B) DMR0P1U MT DTT DMR0P1U MA Inhibitor DMR0P1U RN Novel monoamine oxidase inhibitors: a patent review (2012 - 2014).Expert Opin Ther Pat. 2015 Jan;25(1):91-110. DMR0P1U RU https://www.ncbi.nlm.nih.gov/pubmed/25399762 DMYTEAC DI DMYTEAC DMYTEAC DN PMID25399762-Compound-Table1-C16 DMYTEAC MI TTGP7BY DMYTEAC MN Monoamine oxidase type B (MAO-B) DMYTEAC MT DTT DMYTEAC MA Inhibitor DMYTEAC RN Novel monoamine oxidase inhibitors: a patent review (2012 - 2014).Expert Opin Ther Pat. 2015 Jan;25(1):91-110. DMYTEAC RU https://www.ncbi.nlm.nih.gov/pubmed/25399762 DMNMU3R DI DMNMU3R DMNMU3R DN PMID25399762-Compound-Table1-C17 DMNMU3R MI TTGP7BY DMNMU3R MN Monoamine oxidase type B (MAO-B) DMNMU3R MT DTT DMNMU3R MA Inhibitor DMNMU3R RN Novel monoamine oxidase inhibitors: a patent review (2012 - 2014).Expert Opin Ther Pat. 2015 Jan;25(1):91-110. DMNMU3R RU https://www.ncbi.nlm.nih.gov/pubmed/25399762 DM2ZUVH DI DM2ZUVH DM2ZUVH DN PMID25399762-Compound-Table1-C18 DM2ZUVH MI TTGP7BY DM2ZUVH MN Monoamine oxidase type B (MAO-B) DM2ZUVH MT DTT DM2ZUVH MA Inhibitor DM2ZUVH RN Novel monoamine oxidase inhibitors: a patent review (2012 - 2014).Expert Opin Ther Pat. 2015 Jan;25(1):91-110. DM2ZUVH RU https://www.ncbi.nlm.nih.gov/pubmed/25399762 DMMO3F1 DI DMMO3F1 DMMO3F1 DN PMID25399762-Compound-Table1-C19 DMMO3F1 MI TTGP7BY DMMO3F1 MN Monoamine oxidase type B (MAO-B) DMMO3F1 MT DTT DMMO3F1 MA Inhibitor DMMO3F1 RN Novel monoamine oxidase inhibitors: a patent review (2012 - 2014).Expert Opin Ther Pat. 2015 Jan;25(1):91-110. DMMO3F1 RU https://www.ncbi.nlm.nih.gov/pubmed/25399762 DMPFLGO DI DMPFLGO DMPFLGO DN PMID25399762-Compound-Table1-C2 DMPFLGO MI TTGP7BY DMPFLGO MN Monoamine oxidase type B (MAO-B) DMPFLGO MT DTT DMPFLGO MA Inhibitor DMPFLGO RN Novel monoamine oxidase inhibitors: a patent review (2012 - 2014).Expert Opin Ther Pat. 2015 Jan;25(1):91-110. DMPFLGO RU https://www.ncbi.nlm.nih.gov/pubmed/25399762 DMITNWZ DI DMITNWZ DMITNWZ DN PMID25399762-Compound-Table1-C20 DMITNWZ MI TTGP7BY DMITNWZ MN Monoamine oxidase type B (MAO-B) DMITNWZ MT DTT DMITNWZ MA Inhibitor DMITNWZ RN Novel monoamine oxidase inhibitors: a patent review (2012 - 2014).Expert Opin Ther Pat. 2015 Jan;25(1):91-110. DMITNWZ RU https://www.ncbi.nlm.nih.gov/pubmed/25399762 DMMFILA DI DMMFILA DMMFILA DN PMID25399762-Compound-Table1-C21 DMMFILA MI TTGP7BY DMMFILA MN Monoamine oxidase type B (MAO-B) DMMFILA MT DTT DMMFILA MA Inhibitor DMMFILA RN Novel monoamine oxidase inhibitors: a patent review (2012 - 2014).Expert Opin Ther Pat. 2015 Jan;25(1):91-110. DMMFILA RU https://www.ncbi.nlm.nih.gov/pubmed/25399762 DMBE0R2 DI DMBE0R2 DMBE0R2 DN PMID25399762-Compound-Table1-C22 DMBE0R2 MI TTGP7BY DMBE0R2 MN Monoamine oxidase type B (MAO-B) DMBE0R2 MT DTT DMBE0R2 MA Inhibitor DMBE0R2 RN Novel monoamine oxidase inhibitors: a patent review (2012 - 2014).Expert Opin Ther Pat. 2015 Jan;25(1):91-110. DMBE0R2 RU https://www.ncbi.nlm.nih.gov/pubmed/25399762 DMF89PY DI DMF89PY DMF89PY DN PMID25399762-Compound-Table1-C23 DMF89PY MI TTGP7BY DMF89PY MN Monoamine oxidase type B (MAO-B) DMF89PY MT DTT DMF89PY MA Inhibitor DMF89PY RN Novel monoamine oxidase inhibitors: a patent review (2012 - 2014).Expert Opin Ther Pat. 2015 Jan;25(1):91-110. DMF89PY RU https://www.ncbi.nlm.nih.gov/pubmed/25399762 DMJK296 DI DMJK296 DMJK296 DN PMID25399762-Compound-Table1-C24 DMJK296 MI TTGP7BY DMJK296 MN Monoamine oxidase type B (MAO-B) DMJK296 MT DTT DMJK296 MA Inhibitor DMJK296 RN Novel monoamine oxidase inhibitors: a patent review (2012 - 2014).Expert Opin Ther Pat. 2015 Jan;25(1):91-110. DMJK296 RU https://www.ncbi.nlm.nih.gov/pubmed/25399762 DMHT41B DI DMHT41B DMHT41B DN PMID25399762-Compound-Table1-C25 DMHT41B MI TTGP7BY DMHT41B MN Monoamine oxidase type B (MAO-B) DMHT41B MT DTT DMHT41B MA Inhibitor DMHT41B RN Novel monoamine oxidase inhibitors: a patent review (2012 - 2014).Expert Opin Ther Pat. 2015 Jan;25(1):91-110. DMHT41B RU https://www.ncbi.nlm.nih.gov/pubmed/25399762 DMXAKNH DI DMXAKNH DMXAKNH DN PMID25399762-Compound-Table1-C3 DMXAKNH MI TTGP7BY DMXAKNH MN Monoamine oxidase type B (MAO-B) DMXAKNH MT DTT DMXAKNH MA Inhibitor DMXAKNH RN Novel monoamine oxidase inhibitors: a patent review (2012 - 2014).Expert Opin Ther Pat. 2015 Jan;25(1):91-110. DMXAKNH RU https://www.ncbi.nlm.nih.gov/pubmed/25399762 DMJCVBM DI DMJCVBM DMJCVBM DN PMID25399762-Compound-Table1-C4 DMJCVBM MI TTGP7BY DMJCVBM MN Monoamine oxidase type B (MAO-B) DMJCVBM MT DTT DMJCVBM MA Inhibitor DMJCVBM RN Novel monoamine oxidase inhibitors: a patent review (2012 - 2014).Expert Opin Ther Pat. 2015 Jan;25(1):91-110. DMJCVBM RU https://www.ncbi.nlm.nih.gov/pubmed/25399762 DMEJNUG DI DMEJNUG DMEJNUG DN PMID25399762-Compound-Table1-C5 DMEJNUG MI TTGP7BY DMEJNUG MN Monoamine oxidase type B (MAO-B) DMEJNUG MT DTT DMEJNUG MA Inhibitor DMEJNUG RN Novel monoamine oxidase inhibitors: a patent review (2012 - 2014).Expert Opin Ther Pat. 2015 Jan;25(1):91-110. DMEJNUG RU https://www.ncbi.nlm.nih.gov/pubmed/25399762 DMY3UKC DI DMY3UKC DMY3UKC DN PMID25399762-Compound-Table1-C6 DMY3UKC MI TTGP7BY DMY3UKC MN Monoamine oxidase type B (MAO-B) DMY3UKC MT DTT DMY3UKC MA Inhibitor DMY3UKC RN Novel monoamine oxidase inhibitors: a patent review (2012 - 2014).Expert Opin Ther Pat. 2015 Jan;25(1):91-110. DMY3UKC RU https://www.ncbi.nlm.nih.gov/pubmed/25399762 DMQJV3L DI DMQJV3L DMQJV3L DN PMID25399762-Compound-Table1-C7 DMQJV3L MI TTGP7BY DMQJV3L MN Monoamine oxidase type B (MAO-B) DMQJV3L MT DTT DMQJV3L MA Inhibitor DMQJV3L RN Novel monoamine oxidase inhibitors: a patent review (2012 - 2014).Expert Opin Ther Pat. 2015 Jan;25(1):91-110. DMQJV3L RU https://www.ncbi.nlm.nih.gov/pubmed/25399762 DMRCPKV DI DMRCPKV DMRCPKV DN PMID25399762-Compound-Table1-C8 DMRCPKV MI TTGP7BY DMRCPKV MN Monoamine oxidase type B (MAO-B) DMRCPKV MT DTT DMRCPKV MA Inhibitor DMRCPKV RN Novel monoamine oxidase inhibitors: a patent review (2012 - 2014).Expert Opin Ther Pat. 2015 Jan;25(1):91-110. DMRCPKV RU https://www.ncbi.nlm.nih.gov/pubmed/25399762 DMVMT26 DI DMVMT26 DMVMT26 DN PMID25399762-Compound-Table1-C9 DMVMT26 MI TTGP7BY DMVMT26 MN Monoamine oxidase type B (MAO-B) DMVMT26 MT DTT DMVMT26 MA Inhibitor DMVMT26 RN Novel monoamine oxidase inhibitors: a patent review (2012 - 2014).Expert Opin Ther Pat. 2015 Jan;25(1):91-110. DMVMT26 RU https://www.ncbi.nlm.nih.gov/pubmed/25399762 DMJETVH DI DMJETVH DMJETVH DN PMID25416646-Compound-Figure2-J DMJETVH MI TTZMAO3 DMJETVH MN Peroxisome proliferator-activated receptor gamma (PPAR-gamma) DMJETVH MT DTT DMJETVH MA Agonist DMJETVH RN PPAR ligands and their therapeutic applications: a patent review (2008 - 2014).Expert Opin Ther Pat. 2015 Feb;25(2):175-91. DMJETVH RU https://www.ncbi.nlm.nih.gov/pubmed/25416646 DMNTAYK DI DMNTAYK DMNTAYK DN PMID25416646-Compound-Figure2-K DMNTAYK MI TTZMAO3 DMNTAYK MN Peroxisome proliferator-activated receptor gamma (PPAR-gamma) DMNTAYK MT DTT DMNTAYK MA Agonist DMNTAYK RN PPAR ligands and their therapeutic applications: a patent review (2008 - 2014).Expert Opin Ther Pat. 2015 Feb;25(2):175-91. DMNTAYK RU https://www.ncbi.nlm.nih.gov/pubmed/25416646 DMLDPGY DI DMLDPGY DMLDPGY DN PMID25416646-Compound-Figure2-N DMLDPGY MI TTZMAO3 DMLDPGY MN Peroxisome proliferator-activated receptor gamma (PPAR-gamma) DMLDPGY MT DTT DMLDPGY MA Agonist DMLDPGY RN PPAR ligands and their therapeutic applications: a patent review (2008 - 2014).Expert Opin Ther Pat. 2015 Feb;25(2):175-91. DMLDPGY RU https://www.ncbi.nlm.nih.gov/pubmed/25416646 DM9OHAN DI DM9OHAN DM9OHAN DN PMID25416646-Compound-Figure5-A DM9OHAN MI TTJ584C DM9OHAN MN Peroxisome proliferator-activated receptor alpha (PPARA) DM9OHAN MT DTT DM9OHAN MA Agonist DM9OHAN RN PPAR ligands and their therapeutic applications: a patent review (2008 - 2014).Expert Opin Ther Pat. 2015 Feb;25(2):175-91. DM9OHAN RU https://www.ncbi.nlm.nih.gov/pubmed/25416646 DM9OHAN DI DM9OHAN DM9OHAN DN PMID25416646-Compound-Figure5-A DM9OHAN MI TTZMAO3 DM9OHAN MN Peroxisome proliferator-activated receptor gamma (PPAR-gamma) DM9OHAN MT DTT DM9OHAN MA Agonist DM9OHAN RN PPAR ligands and their therapeutic applications: a patent review (2008 - 2014).Expert Opin Ther Pat. 2015 Feb;25(2):175-91. DM9OHAN RU https://www.ncbi.nlm.nih.gov/pubmed/25416646 DM17FKL DI DM17FKL DM17FKL DN PMID25416646-Compound-Figure5-C DM17FKL MI TT2JWF6 DM17FKL MN Peroxisome proliferator-activated receptor delta (PPARD) DM17FKL MT DTT DM17FKL MA Agonist DM17FKL RN PPAR ligands and their therapeutic applications: a patent review (2008 - 2014).Expert Opin Ther Pat. 2015 Feb;25(2):175-91. DM17FKL RU https://www.ncbi.nlm.nih.gov/pubmed/25416646 DM17FKL DI DM17FKL DM17FKL DN PMID25416646-Compound-Figure5-C DM17FKL MI TTZMAO3 DM17FKL MN Peroxisome proliferator-activated receptor gamma (PPAR-gamma) DM17FKL MT DTT DM17FKL MA Agonist DM17FKL RN PPAR ligands and their therapeutic applications: a patent review (2008 - 2014).Expert Opin Ther Pat. 2015 Feb;25(2):175-91. DM17FKL RU https://www.ncbi.nlm.nih.gov/pubmed/25416646 DMYO7VH DI DMYO7VH DMYO7VH DN PMID25416646-Compound-Figure5-E DMYO7VH MI TTQVOEI DMYO7VH MN Angiotensin II receptor type-2 (AGTR2) DMYO7VH MT DTT DMYO7VH MA Agonist DMYO7VH RN PPAR ligands and their therapeutic applications: a patent review (2008 - 2014).Expert Opin Ther Pat. 2015 Feb;25(2):175-91. DMYO7VH RU https://www.ncbi.nlm.nih.gov/pubmed/25416646 DMYO7VH DI DMYO7VH DMYO7VH DN PMID25416646-Compound-Figure5-E DMYO7VH MI TTZMAO3 DMYO7VH MN Peroxisome proliferator-activated receptor gamma (PPAR-gamma) DMYO7VH MT DTT DMYO7VH MA Agonist DMYO7VH RN PPAR ligands and their therapeutic applications: a patent review (2008 - 2014).Expert Opin Ther Pat. 2015 Feb;25(2):175-91. DMYO7VH RU https://www.ncbi.nlm.nih.gov/pubmed/25416646 DMCJTU1 DI DMCJTU1 DMCJTU1 DN PMID25416646-Compound-Figure5-H DMCJTU1 MI TTJ584C DMCJTU1 MN Peroxisome proliferator-activated receptor alpha (PPARA) DMCJTU1 MT DTT DMCJTU1 MA Agonist DMCJTU1 RN PPAR ligands and their therapeutic applications: a patent review (2008 - 2014).Expert Opin Ther Pat. 2015 Feb;25(2):175-91. DMCJTU1 RU https://www.ncbi.nlm.nih.gov/pubmed/25416646 DMCJTU1 DI DMCJTU1 DMCJTU1 DN PMID25416646-Compound-Figure5-H DMCJTU1 MI TTZMAO3 DMCJTU1 MN Peroxisome proliferator-activated receptor gamma (PPAR-gamma) DMCJTU1 MT DTT DMCJTU1 MA Agonist DMCJTU1 RN PPAR ligands and their therapeutic applications: a patent review (2008 - 2014).Expert Opin Ther Pat. 2015 Feb;25(2):175-91. DMCJTU1 RU https://www.ncbi.nlm.nih.gov/pubmed/25416646 DMMRUVT DI DMMRUVT DMMRUVT DN PMID25435179-Compound-EP20142759295NP-1 DMMRUVT MI TTSCO7R DMMRUVT MN NAD-dependent deacetylase sirtuin (SIRT) DMMRUVT MT DTT DMMRUVT MA Inhibitor DMMRUVT RN Sirtuin modulators: an updated patent review (2012 - 2014).Expert Opin Ther Pat. 2015 Jan;25(1):5-15. DMMRUVT RU https://www.ncbi.nlm.nih.gov/pubmed/25435179 DMXJT8R DI DMXJT8R DMXJT8R DN PMID25435179-Compound-US2012165330(I) DMXJT8R MI TTSCO7R DMXJT8R MN NAD-dependent deacetylase sirtuin (SIRT) DMXJT8R MT DTT DMXJT8R MA Inhibitor DMXJT8R RN Sirtuin modulators: an updated patent review (2012 - 2014).Expert Opin Ther Pat. 2015 Jan;25(1):5-15. DMXJT8R RU https://www.ncbi.nlm.nih.gov/pubmed/25435179 DMMRT0Q DI DMMRT0Q DMMRT0Q DN PMID25435179-Compound-WO2012006391H3K9TSu DMMRT0Q MI TTSCO7R DMMRT0Q MN NAD-dependent deacetylase sirtuin (SIRT) DMMRT0Q MT DTT DMMRT0Q MA Inhibitor DMMRT0Q RN Sirtuin modulators: an updated patent review (2012 - 2014).Expert Opin Ther Pat. 2015 Jan;25(1):5-15. DMMRT0Q RU https://www.ncbi.nlm.nih.gov/pubmed/25435179 DM2F1T0 DI DM2F1T0 DM2F1T0 DN PMID25435179-Compound-WO2012106509CAY10602 DM2F1T0 MI TTUF2HO DM2F1T0 MN NAD-dependent deacetylase sirtuin-1 (SIRT1) DM2F1T0 MT DTT DM2F1T0 MA Inhibitor DM2F1T0 RN Sirtuin modulators: an updated patent review (2012 - 2014).Expert Opin Ther Pat. 2015 Jan;25(1):5-15. DM2F1T0 RU https://www.ncbi.nlm.nih.gov/pubmed/25435179 DMLAH39 DI DMLAH39 DMLAH39 DN PMID25435179-Compound-WO2012106509Salermide DMLAH39 MI TTUF2HO DMLAH39 MN NAD-dependent deacetylase sirtuin-1 (SIRT1) DMLAH39 MT DTT DMLAH39 MA Inhibitor DMLAH39 RN Sirtuin modulators: an updated patent review (2012 - 2014).Expert Opin Ther Pat. 2015 Jan;25(1):5-15. DMLAH39 RU https://www.ncbi.nlm.nih.gov/pubmed/25435179 DMBSOED DI DMBSOED DMBSOED DN PMID25435179-Compound-WO2012106509Tenovin-6 DMBSOED MI TTUF2HO DMBSOED MN NAD-dependent deacetylase sirtuin-1 (SIRT1) DMBSOED MT DTT DMBSOED MA Inhibitor DMBSOED RN Sirtuin modulators: an updated patent review (2012 - 2014).Expert Opin Ther Pat. 2015 Jan;25(1):5-15. DMBSOED RU https://www.ncbi.nlm.nih.gov/pubmed/25435179 DM79BFU DI DM79BFU DM79BFU DN PMID25435179-Compound-WO2012149608USYDS1 DM79BFU MI TTSCO7R DM79BFU MN NAD-dependent deacetylase sirtuin (SIRT) DM79BFU MT DTT DM79BFU MA Inhibitor DM79BFU RN Sirtuin modulators: an updated patent review (2012 - 2014).Expert Opin Ther Pat. 2015 Jan;25(1):5-15. DM79BFU RU https://www.ncbi.nlm.nih.gov/pubmed/25435179 DMIHRG4 DI DMIHRG4 DMIHRG4 DN PMID25435179-Compound-WO2013059587(V, 1st set) DMIHRG4 MI TTSCO7R DMIHRG4 MN NAD-dependent deacetylase sirtuin (SIRT) DMIHRG4 MT DTT DMIHRG4 MA Inhibitor DMIHRG4 RN Sirtuin modulators: an updated patent review (2012 - 2014).Expert Opin Ther Pat. 2015 Jan;25(1):5-15. DMIHRG4 RU https://www.ncbi.nlm.nih.gov/pubmed/25435179 DM7YJ4L DI DM7YJ4L DM7YJ4L DN PMID25435179-Compound-WO2013059587(VI, 2nd set) DM7YJ4L MI TTSCO7R DM7YJ4L MN NAD-dependent deacetylase sirtuin (SIRT) DM7YJ4L MT DTT DM7YJ4L MA Inhibitor DM7YJ4L RN Sirtuin modulators: an updated patent review (2012 - 2014).Expert Opin Ther Pat. 2015 Jan;25(1):5-15. DM7YJ4L RU https://www.ncbi.nlm.nih.gov/pubmed/25435179 DMLUWCD DI DMLUWCD DMLUWCD DN PMID25435179-Compound-WO2013059594(III) DMLUWCD MI TTSCO7R DMLUWCD MN NAD-dependent deacetylase sirtuin (SIRT) DMLUWCD MT DTT DMLUWCD MA Inhibitor DMLUWCD RN Sirtuin modulators: an updated patent review (2012 - 2014).Expert Opin Ther Pat. 2015 Jan;25(1):5-15. DMLUWCD RU https://www.ncbi.nlm.nih.gov/pubmed/25435179 DMK90ED DI DMK90ED DMK90ED DN PMID25435179-Compound-WO2013059594(IV) DMK90ED MI TTSCO7R DMK90ED MN NAD-dependent deacetylase sirtuin (SIRT) DMK90ED MT DTT DMK90ED MA Inhibitor DMK90ED RN Sirtuin modulators: an updated patent review (2012 - 2014).Expert Opin Ther Pat. 2015 Jan;25(1):5-15. DMK90ED RU https://www.ncbi.nlm.nih.gov/pubmed/25435179 DMXC3UP DI DMXC3UP DMXC3UP DN PMID25435179-Compound-WO2014110399Splitomycin DMXC3UP MI TTSCO7R DMXC3UP MN NAD-dependent deacetylase sirtuin (SIRT) DMXC3UP MT DTT DMXC3UP MA Inhibitor DMXC3UP RN Sirtuin modulators: an updated patent review (2012 - 2014).Expert Opin Ther Pat. 2015 Jan;25(1):5-15. DMXC3UP RU https://www.ncbi.nlm.nih.gov/pubmed/25435179 DM12QO7 DI DM12QO7 DM12QO7 DN PMID25435285-Compound-10 DM12QO7 MI TTXJ47W DM12QO7 MN Metabotropic glutamate receptor 2 (mGluR2) DM12QO7 MT DTT DM12QO7 MA Antagonist DM12QO7 RN Novel metabotropic glutamate receptor 2/3 antagonists and their therapeutic applications: a patent review (2005 - present).Expert Opin Ther Pat. 2015 Jan;25(1):69-90. DM12QO7 RU https://www.ncbi.nlm.nih.gov/pubmed/25435285 DMHBWNS DI DMHBWNS DMHBWNS DN PMID25435285-Compound-15 DMHBWNS MI TTXJ47W DMHBWNS MN Metabotropic glutamate receptor 2 (mGluR2) DMHBWNS MT DTT DMHBWNS MA Antagonist DMHBWNS RN Novel metabotropic glutamate receptor 2/3 antagonists and their therapeutic applications: a patent review (2005 - present).Expert Opin Ther Pat. 2015 Jan;25(1):69-90. DMHBWNS RU https://www.ncbi.nlm.nih.gov/pubmed/25435285 DMHBWNS DI DMHBWNS DMHBWNS DN PMID25435285-Compound-15 DMHBWNS MI TT8A9EF DMHBWNS MN Metabotropic glutamate receptor 3 (mGluR3) DMHBWNS MT DTT DMHBWNS MA Antagonist DMHBWNS RN Novel metabotropic glutamate receptor 2/3 antagonists and their therapeutic applications: a patent review (2005 - present).Expert Opin Ther Pat. 2015 Jan;25(1):69-90. DMHBWNS RU https://www.ncbi.nlm.nih.gov/pubmed/25435285 DMKFX2G DI DMKFX2G DMKFX2G DN PMID25435285-Compound-16 DMKFX2G MI TTXJ47W DMKFX2G MN Metabotropic glutamate receptor 2 (mGluR2) DMKFX2G MT DTT DMKFX2G MA Antagonist DMKFX2G RN Novel metabotropic glutamate receptor 2/3 antagonists and their therapeutic applications: a patent review (2005 - present).Expert Opin Ther Pat. 2015 Jan;25(1):69-90. DMKFX2G RU https://www.ncbi.nlm.nih.gov/pubmed/25435285 DMKFX2G DI DMKFX2G DMKFX2G DN PMID25435285-Compound-16 DMKFX2G MI TT8A9EF DMKFX2G MN Metabotropic glutamate receptor 3 (mGluR3) DMKFX2G MT DTT DMKFX2G MA Antagonist DMKFX2G RN Novel metabotropic glutamate receptor 2/3 antagonists and their therapeutic applications: a patent review (2005 - present).Expert Opin Ther Pat. 2015 Jan;25(1):69-90. DMKFX2G RU https://www.ncbi.nlm.nih.gov/pubmed/25435285 DMG9FYH DI DMG9FYH DMG9FYH DN PMID25435285-Compound-20 DMG9FYH MI TTXJ47W DMG9FYH MN Metabotropic glutamate receptor 2 (mGluR2) DMG9FYH MT DTT DMG9FYH MA Antagonist DMG9FYH RN Novel metabotropic glutamate receptor 2/3 antagonists and their therapeutic applications: a patent review (2005 - present).Expert Opin Ther Pat. 2015 Jan;25(1):69-90. DMG9FYH RU https://www.ncbi.nlm.nih.gov/pubmed/25435285 DMG9FYH DI DMG9FYH DMG9FYH DN PMID25435285-Compound-20 DMG9FYH MI TT8A9EF DMG9FYH MN Metabotropic glutamate receptor 3 (mGluR3) DMG9FYH MT DTT DMG9FYH MA Antagonist DMG9FYH RN Novel metabotropic glutamate receptor 2/3 antagonists and their therapeutic applications: a patent review (2005 - present).Expert Opin Ther Pat. 2015 Jan;25(1):69-90. DMG9FYH RU https://www.ncbi.nlm.nih.gov/pubmed/25435285 DM27U1F DI DM27U1F DM27U1F DN PMID25435285-Compound-22 DM27U1F MI TTXJ47W DM27U1F MN Metabotropic glutamate receptor 2 (mGluR2) DM27U1F MT DTT DM27U1F MA Antagonist DM27U1F RN Novel metabotropic glutamate receptor 2/3 antagonists and their therapeutic applications: a patent review (2005 - present).Expert Opin Ther Pat. 2015 Jan;25(1):69-90. DM27U1F RU https://www.ncbi.nlm.nih.gov/pubmed/25435285 DM27U1F DI DM27U1F DM27U1F DN PMID25435285-Compound-22 DM27U1F MI TT8A9EF DM27U1F MN Metabotropic glutamate receptor 3 (mGluR3) DM27U1F MT DTT DM27U1F MA Antagonist DM27U1F RN Novel metabotropic glutamate receptor 2/3 antagonists and their therapeutic applications: a patent review (2005 - present).Expert Opin Ther Pat. 2015 Jan;25(1):69-90. DM27U1F RU https://www.ncbi.nlm.nih.gov/pubmed/25435285 DMIVJMO DI DMIVJMO DMIVJMO DN PMID25435285-Compound-25 DMIVJMO MI TTXJ47W DMIVJMO MN Metabotropic glutamate receptor 2 (mGluR2) DMIVJMO MT DTT DMIVJMO MA Antagonist DMIVJMO RN Novel metabotropic glutamate receptor 2/3 antagonists and their therapeutic applications: a patent review (2005 - present).Expert Opin Ther Pat. 2015 Jan;25(1):69-90. DMIVJMO RU https://www.ncbi.nlm.nih.gov/pubmed/25435285 DMTJHAK DI DMTJHAK DMTJHAK DN PMID25435285-Compound-26 DMTJHAK MI TTXJ47W DMTJHAK MN Metabotropic glutamate receptor 2 (mGluR2) DMTJHAK MT DTT DMTJHAK MA Antagonist DMTJHAK RN Novel metabotropic glutamate receptor 2/3 antagonists and their therapeutic applications: a patent review (2005 - present).Expert Opin Ther Pat. 2015 Jan;25(1):69-90. DMTJHAK RU https://www.ncbi.nlm.nih.gov/pubmed/25435285 DMTYHCU DI DMTYHCU DMTYHCU DN PMID25435285-Compound-37 DMTYHCU MI TTXJ47W DMTYHCU MN Metabotropic glutamate receptor 2 (mGluR2) DMTYHCU MT DTT DMTYHCU MA Antagonist DMTYHCU RN Novel metabotropic glutamate receptor 2/3 antagonists and their therapeutic applications: a patent review (2005 - present).Expert Opin Ther Pat. 2015 Jan;25(1):69-90. DMTYHCU RU https://www.ncbi.nlm.nih.gov/pubmed/25435285 DMSIKM2 DI DMSIKM2 DMSIKM2 DN PMID25435285-Compound-38 DMSIKM2 MI TTXJ47W DMSIKM2 MN Metabotropic glutamate receptor 2 (mGluR2) DMSIKM2 MT DTT DMSIKM2 MA Antagonist DMSIKM2 RN Novel metabotropic glutamate receptor 2/3 antagonists and their therapeutic applications: a patent review (2005 - present).Expert Opin Ther Pat. 2015 Jan;25(1):69-90. DMSIKM2 RU https://www.ncbi.nlm.nih.gov/pubmed/25435285 DMG2ES1 DI DMG2ES1 DMG2ES1 DN PMID25435285-Compound-39 DMG2ES1 MI TTXJ47W DMG2ES1 MN Metabotropic glutamate receptor 2 (mGluR2) DMG2ES1 MT DTT DMG2ES1 MA Antagonist DMG2ES1 RN Novel metabotropic glutamate receptor 2/3 antagonists and their therapeutic applications: a patent review (2005 - present).Expert Opin Ther Pat. 2015 Jan;25(1):69-90. DMG2ES1 RU https://www.ncbi.nlm.nih.gov/pubmed/25435285 DMW2C19 DI DMW2C19 DMW2C19 DN PMID25435285-Compound-40 DMW2C19 MI TTXJ47W DMW2C19 MN Metabotropic glutamate receptor 2 (mGluR2) DMW2C19 MT DTT DMW2C19 MA Antagonist DMW2C19 RN Novel metabotropic glutamate receptor 2/3 antagonists and their therapeutic applications: a patent review (2005 - present).Expert Opin Ther Pat. 2015 Jan;25(1):69-90. DMW2C19 RU https://www.ncbi.nlm.nih.gov/pubmed/25435285 DMJ5LGA DI DMJ5LGA DMJ5LGA DN PMID25435285-Compound-41 DMJ5LGA MI TTXJ47W DMJ5LGA MN Metabotropic glutamate receptor 2 (mGluR2) DMJ5LGA MT DTT DMJ5LGA MA Antagonist DMJ5LGA RN Novel metabotropic glutamate receptor 2/3 antagonists and their therapeutic applications: a patent review (2005 - present).Expert Opin Ther Pat. 2015 Jan;25(1):69-90. DMJ5LGA RU https://www.ncbi.nlm.nih.gov/pubmed/25435285 DMTN79G DI DMTN79G DMTN79G DN PMID25435285-Compound-42 DMTN79G MI TTXJ47W DMTN79G MN Metabotropic glutamate receptor 2 (mGluR2) DMTN79G MT DTT DMTN79G MA Antagonist DMTN79G RN Novel metabotropic glutamate receptor 2/3 antagonists and their therapeutic applications: a patent review (2005 - present).Expert Opin Ther Pat. 2015 Jan;25(1):69-90. DMTN79G RU https://www.ncbi.nlm.nih.gov/pubmed/25435285 DMEGJ73 DI DMEGJ73 DMEGJ73 DN PMID25435285-Compound-43 DMEGJ73 MI TTXJ47W DMEGJ73 MN Metabotropic glutamate receptor 2 (mGluR2) DMEGJ73 MT DTT DMEGJ73 MA Antagonist DMEGJ73 RN Novel metabotropic glutamate receptor 2/3 antagonists and their therapeutic applications: a patent review (2005 - present).Expert Opin Ther Pat. 2015 Jan;25(1):69-90. DMEGJ73 RU https://www.ncbi.nlm.nih.gov/pubmed/25435285 DM4K3AU DI DM4K3AU DM4K3AU DN PMID25435285-Compound-44 DM4K3AU MI TTXJ47W DM4K3AU MN Metabotropic glutamate receptor 2 (mGluR2) DM4K3AU MT DTT DM4K3AU MA Antagonist DM4K3AU RN Novel metabotropic glutamate receptor 2/3 antagonists and their therapeutic applications: a patent review (2005 - present).Expert Opin Ther Pat. 2015 Jan;25(1):69-90. DM4K3AU RU https://www.ncbi.nlm.nih.gov/pubmed/25435285 DM74WSJ DI DM74WSJ DM74WSJ DN PMID25435285-Compound-45 DM74WSJ MI TTXJ47W DM74WSJ MN Metabotropic glutamate receptor 2 (mGluR2) DM74WSJ MT DTT DM74WSJ MA Antagonist DM74WSJ RN Novel metabotropic glutamate receptor 2/3 antagonists and their therapeutic applications: a patent review (2005 - present).Expert Opin Ther Pat. 2015 Jan;25(1):69-90. DM74WSJ RU https://www.ncbi.nlm.nih.gov/pubmed/25435285 DMC6HPV DI DMC6HPV DMC6HPV DN PMID25435285-Compound-46 DMC6HPV MI TTXJ47W DMC6HPV MN Metabotropic glutamate receptor 2 (mGluR2) DMC6HPV MT DTT DMC6HPV MA Antagonist DMC6HPV RN Novel metabotropic glutamate receptor 2/3 antagonists and their therapeutic applications: a patent review (2005 - present).Expert Opin Ther Pat. 2015 Jan;25(1):69-90. DMC6HPV RU https://www.ncbi.nlm.nih.gov/pubmed/25435285 DM92F1C DI DM92F1C DM92F1C DN PMID25435285-Compound-47 DM92F1C MI TTXJ47W DM92F1C MN Metabotropic glutamate receptor 2 (mGluR2) DM92F1C MT DTT DM92F1C MA Antagonist DM92F1C RN Novel metabotropic glutamate receptor 2/3 antagonists and their therapeutic applications: a patent review (2005 - present).Expert Opin Ther Pat. 2015 Jan;25(1):69-90. DM92F1C RU https://www.ncbi.nlm.nih.gov/pubmed/25435285 DM7G51M DI DM7G51M DM7G51M DN PMID25435285-Compound-49 DM7G51M MI TTXJ47W DM7G51M MN Metabotropic glutamate receptor 2 (mGluR2) DM7G51M MT DTT DM7G51M MA Antagonist DM7G51M RN Novel metabotropic glutamate receptor 2/3 antagonists and their therapeutic applications: a patent review (2005 - present).Expert Opin Ther Pat. 2015 Jan;25(1):69-90. DM7G51M RU https://www.ncbi.nlm.nih.gov/pubmed/25435285 DML48NA DI DML48NA DML48NA DN PMID25435285-Compound-50 DML48NA MI TTXJ47W DML48NA MN Metabotropic glutamate receptor 2 (mGluR2) DML48NA MT DTT DML48NA MA Antagonist DML48NA RN Novel metabotropic glutamate receptor 2/3 antagonists and their therapeutic applications: a patent review (2005 - present).Expert Opin Ther Pat. 2015 Jan;25(1):69-90. DML48NA RU https://www.ncbi.nlm.nih.gov/pubmed/25435285 DM2VZG6 DI DM2VZG6 DM2VZG6 DN PMID25435285-Compound-51 DM2VZG6 MI TTXJ47W DM2VZG6 MN Metabotropic glutamate receptor 2 (mGluR2) DM2VZG6 MT DTT DM2VZG6 MA Antagonist DM2VZG6 RN Novel metabotropic glutamate receptor 2/3 antagonists and their therapeutic applications: a patent review (2005 - present).Expert Opin Ther Pat. 2015 Jan;25(1):69-90. DM2VZG6 RU https://www.ncbi.nlm.nih.gov/pubmed/25435285 DMXD8L1 DI DMXD8L1 DMXD8L1 DN PMID25435285-Compound-52 DMXD8L1 MI TTXJ47W DMXD8L1 MN Metabotropic glutamate receptor 2 (mGluR2) DMXD8L1 MT DTT DMXD8L1 MA Antagonist DMXD8L1 RN Novel metabotropic glutamate receptor 2/3 antagonists and their therapeutic applications: a patent review (2005 - present).Expert Opin Ther Pat. 2015 Jan;25(1):69-90. DMXD8L1 RU https://www.ncbi.nlm.nih.gov/pubmed/25435285 DMSRYIP DI DMSRYIP DMSRYIP DN PMID25435285-Compound-53 DMSRYIP MI TTXJ47W DMSRYIP MN Metabotropic glutamate receptor 2 (mGluR2) DMSRYIP MT DTT DMSRYIP MA Antagonist DMSRYIP RN Novel metabotropic glutamate receptor 2/3 antagonists and their therapeutic applications: a patent review (2005 - present).Expert Opin Ther Pat. 2015 Jan;25(1):69-90. DMSRYIP RU https://www.ncbi.nlm.nih.gov/pubmed/25435285 DMSKCEH DI DMSKCEH DMSKCEH DN PMID25468267-Compound-46 DMSKCEH MI TTZHPB8 DMSKCEH MN Lysine-specific demethylase 4A (KDM4A) DMSKCEH MT DTT DMSKCEH MA Inhibitor DMSKCEH RN KDM4 histone demethylase inhibitors for anti-cancer agents: a patent review.Expert Opin Ther Pat. 2015 Feb;25(2):135-44. DMSKCEH RU https://www.ncbi.nlm.nih.gov/pubmed/25468267 DMSKCEH DI DMSKCEH DMSKCEH DN PMID25468267-Compound-46 DMSKCEH MI TTV8CRH DMSKCEH MN Lysine-specific demethylase 4C (KDM4C) DMSKCEH MT DTT DMSKCEH MA Inhibitor DMSKCEH RN KDM4 histone demethylase inhibitors for anti-cancer agents: a patent review.Expert Opin Ther Pat. 2015 Feb;25(2):135-44. DMSKCEH RU https://www.ncbi.nlm.nih.gov/pubmed/25468267 DMSKCEH DI DMSKCEH DMSKCEH DN PMID25468267-Compound-46 DMSKCEH MI TTWAQBO DMSKCEH MN Lysine-specific demethylase 4E (KDM4E) DMSKCEH MT DTT DMSKCEH MA Inhibitor DMSKCEH RN KDM4 histone demethylase inhibitors for anti-cancer agents: a patent review.Expert Opin Ther Pat. 2015 Feb;25(2):135-44. DMSKCEH RU https://www.ncbi.nlm.nih.gov/pubmed/25468267 DMG2JEK DI DMG2JEK DMG2JEK DN PMID25468267-Compound-47 DMG2JEK MI TTV8CRH DMG2JEK MN Lysine-specific demethylase 4C (KDM4C) DMG2JEK MT DTT DMG2JEK MA Inhibitor DMG2JEK RN KDM4 histone demethylase inhibitors for anti-cancer agents: a patent review.Expert Opin Ther Pat. 2015 Feb;25(2):135-44. DMG2JEK RU https://www.ncbi.nlm.nih.gov/pubmed/25468267 DMBPT9Z DI DMBPT9Z DMBPT9Z DN PMID25468267-Compound-48 DMBPT9Z MI TT0RGE9 DMBPT9Z MN Lysine-specific demethylase 4 (KDM4) DMBPT9Z MT DTT DMBPT9Z MA Inhibitor DMBPT9Z RN KDM4 histone demethylase inhibitors for anti-cancer agents: a patent review.Expert Opin Ther Pat. 2015 Feb;25(2):135-44. DMBPT9Z RU https://www.ncbi.nlm.nih.gov/pubmed/25468267 DM2HG9U DI DM2HG9U DM2HG9U DN PMID25468267-Compound-49 DM2HG9U MI TT0RGE9 DM2HG9U MN Lysine-specific demethylase 4 (KDM4) DM2HG9U MT DTT DM2HG9U MA Inhibitor DM2HG9U RN KDM4 histone demethylase inhibitors for anti-cancer agents: a patent review.Expert Opin Ther Pat. 2015 Feb;25(2):135-44. DM2HG9U RU https://www.ncbi.nlm.nih.gov/pubmed/25468267 DMIVJ2W DI DMIVJ2W DMIVJ2W DN PMID25468267-Compound-50 DMIVJ2W MI TT0RGE9 DMIVJ2W MN Lysine-specific demethylase 4 (KDM4) DMIVJ2W MT DTT DMIVJ2W MA Inhibitor DMIVJ2W RN KDM4 histone demethylase inhibitors for anti-cancer agents: a patent review.Expert Opin Ther Pat. 2015 Feb;25(2):135-44. DMIVJ2W RU https://www.ncbi.nlm.nih.gov/pubmed/25468267 DMNPC0H DI DMNPC0H DMNPC0H DN PMID25468267-Compound-51 DMNPC0H MI TT0RGE9 DMNPC0H MN Lysine-specific demethylase 4 (KDM4) DMNPC0H MT DTT DMNPC0H MA Inhibitor DMNPC0H RN KDM4 histone demethylase inhibitors for anti-cancer agents: a patent review.Expert Opin Ther Pat. 2015 Feb;25(2):135-44. DMNPC0H RU https://www.ncbi.nlm.nih.gov/pubmed/25468267 DMAH1G7 DI DMAH1G7 DMAH1G7 DN PMID25468267-Compound-52 DMAH1G7 MI TT0RGE9 DMAH1G7 MN Lysine-specific demethylase 4 (KDM4) DMAH1G7 MT DTT DMAH1G7 MA Inhibitor DMAH1G7 RN KDM4 histone demethylase inhibitors for anti-cancer agents: a patent review.Expert Opin Ther Pat. 2015 Feb;25(2):135-44. DMAH1G7 RU https://www.ncbi.nlm.nih.gov/pubmed/25468267 DMONWYI DI DMONWYI DMONWYI DN PMID25468267-Compound-53 DMONWYI MI TT0RGE9 DMONWYI MN Lysine-specific demethylase 4 (KDM4) DMONWYI MT DTT DMONWYI MA Inhibitor DMONWYI RN KDM4 histone demethylase inhibitors for anti-cancer agents: a patent review.Expert Opin Ther Pat. 2015 Feb;25(2):135-44. DMONWYI RU https://www.ncbi.nlm.nih.gov/pubmed/25468267 DMI93AX DI DMI93AX DMI93AX DN PMID25468267-Compound-54 DMI93AX MI TT0RGE9 DMI93AX MN Lysine-specific demethylase 4 (KDM4) DMI93AX MT DTT DMI93AX MA Inhibitor DMI93AX RN KDM4 histone demethylase inhibitors for anti-cancer agents: a patent review.Expert Opin Ther Pat. 2015 Feb;25(2):135-44. DMI93AX RU https://www.ncbi.nlm.nih.gov/pubmed/25468267 DMIXQRY DI DMIXQRY DMIXQRY DN PMID25468267-Compound-55 DMIXQRY MI TTV8CRH DMIXQRY MN Lysine-specific demethylase 4C (KDM4C) DMIXQRY MT DTT DMIXQRY MA Inhibitor DMIXQRY RN KDM4 histone demethylase inhibitors for anti-cancer agents: a patent review.Expert Opin Ther Pat. 2015 Feb;25(2):135-44. DMIXQRY RU https://www.ncbi.nlm.nih.gov/pubmed/25468267 DMAI19Z DI DMAI19Z DMAI19Z DN PMID25468267-Compound-56 DMAI19Z MI TTV8CRH DMAI19Z MN Lysine-specific demethylase 4C (KDM4C) DMAI19Z MT DTT DMAI19Z MA Inhibitor DMAI19Z RN KDM4 histone demethylase inhibitors for anti-cancer agents: a patent review.Expert Opin Ther Pat. 2015 Feb;25(2):135-44. DMAI19Z RU https://www.ncbi.nlm.nih.gov/pubmed/25468267 DM6EN54 DI DM6EN54 DM6EN54 DN PMID25470667-Compound-AZD3988 DM6EN54 MI TTF8P9I DM6EN54 MN Diacylglycerol acyltransferase 1 (DGAT1) DM6EN54 MT DTT DM6EN54 MA Inhibitor DM6EN54 RN Acyltransferase inhibitors: a patent review (2010-present).Expert Opin Ther Pat. 2015 Feb;25(2):145-58. DM6EN54 RU https://www.ncbi.nlm.nih.gov/pubmed/25470667 DMY3140 DI DMY3140 DMY3140 DN PMID25470667-Compound-BAY744113 DMY3140 MI TTF8P9I DMY3140 MN Diacylglycerol acyltransferase 1 (DGAT1) DMY3140 MT DTT DMY3140 MA Inhibitor DMY3140 RN Acyltransferase inhibitors: a patent review (2010-present).Expert Opin Ther Pat. 2015 Feb;25(2):145-58. DMY3140 RU https://www.ncbi.nlm.nih.gov/pubmed/25470667 DMMVQW8 DI DMMVQW8 DMMVQW8 DN PMID25470667-Compound-Figure4-1A DMMVQW8 MI TTF8P9I DMMVQW8 MN Diacylglycerol acyltransferase 1 (DGAT1) DMMVQW8 MT DTT DMMVQW8 MA Inhibitor DMMVQW8 RN Acyltransferase inhibitors: a patent review (2010-present).Expert Opin Ther Pat. 2015 Feb;25(2):145-58. DMMVQW8 RU https://www.ncbi.nlm.nih.gov/pubmed/25470667 DMMVQW8 DI DMMVQW8 DMMVQW8 DN PMID25470667-Compound-Figure4-1A DMMVQW8 MI TTRHEQ4 DMMVQW8 MN Diacylglycerol O-acyltransferase 2 (DGAT2) DMMVQW8 MT DTT DMMVQW8 MA Inhibitor DMMVQW8 RN Acyltransferase inhibitors: a patent review (2010-present).Expert Opin Ther Pat. 2015 Feb;25(2):145-58. DMMVQW8 RU https://www.ncbi.nlm.nih.gov/pubmed/25470667 DME40TS DI DME40TS DME40TS DN PMID25470667-Compound-GO-CoA-Tat DME40TS MI TTSYOWR DME40TS MN Ghrelin O acyltransferase (GOAT) DME40TS MT DTT DME40TS MA Inhibitor DME40TS RN Acyltransferase inhibitors: a patent review (2010-present).Expert Opin Ther Pat. 2015 Feb;25(2):145-58. DME40TS RU https://www.ncbi.nlm.nih.gov/pubmed/25470667 DMYZ2UA DI DMYZ2UA DMYZ2UA DN PMID25470667-Compound-K-604 DMYZ2UA MI TTK3C21 DMYZ2UA MN Acetoacetyl-CoA thiolase (ACAT1) DMYZ2UA MT DTT DMYZ2UA MA Inhibitor DMYZ2UA RN Acyltransferase inhibitors: a patent review (2010-present).Expert Opin Ther Pat. 2015 Feb;25(2):145-58. DMYZ2UA RU https://www.ncbi.nlm.nih.gov/pubmed/25470667 DM0OBAW DI DM0OBAW DM0OBAW DN PMID25470667-Compound-PF-04620110 DM0OBAW MI TTF8P9I DM0OBAW MN Diacylglycerol acyltransferase 1 (DGAT1) DM0OBAW MT DTT DM0OBAW MA Inhibitor DM0OBAW RN Acyltransferase inhibitors: a patent review (2010-present).Expert Opin Ther Pat. 2015 Feb;25(2):145-58. DM0OBAW RU https://www.ncbi.nlm.nih.gov/pubmed/25470667 DMCF2G7 DI DMCF2G7 DMCF2G7 DN PMID25470667-Compound-roselipins DMCF2G7 MI TTRHEQ4 DMCF2G7 MN Diacylglycerol O-acyltransferase 2 (DGAT2) DMCF2G7 MT DTT DMCF2G7 MA Inhibitor DMCF2G7 RN Acyltransferase inhibitors: a patent review (2010-present).Expert Opin Ther Pat. 2015 Feb;25(2):145-58. DMCF2G7 RU https://www.ncbi.nlm.nih.gov/pubmed/25470667 DMQB4LE DI DMQB4LE DMQB4LE DN PMID25482888-Compound-11 DMQB4LE MI TTDIGC1 DMQB4LE MN Dipeptidyl peptidase 4 (DPP-4) DMQB4LE MT DTT DMQB4LE MA Inhibitor DMQB4LE RN DPP-4 inhibitors: a patent review (2012 - 2014).Expert Opin Ther Pat. 2015 Feb;25(2):209-36. DMQB4LE RU https://www.ncbi.nlm.nih.gov/pubmed/25482888 DM8JIDR DI DM8JIDR DM8JIDR DN PMID25482888-Compound-12 DM8JIDR MI TTDIGC1 DM8JIDR MN Dipeptidyl peptidase 4 (DPP-4) DM8JIDR MT DTT DM8JIDR MA Inhibitor DM8JIDR RN DPP-4 inhibitors: a patent review (2012 - 2014).Expert Opin Ther Pat. 2015 Feb;25(2):209-36. DM8JIDR RU https://www.ncbi.nlm.nih.gov/pubmed/25482888 DMBS2FT DI DMBS2FT DMBS2FT DN PMID25482888-Compound-13 DMBS2FT MI TTDIGC1 DMBS2FT MN Dipeptidyl peptidase 4 (DPP-4) DMBS2FT MT DTT DMBS2FT MA Inhibitor DMBS2FT RN DPP-4 inhibitors: a patent review (2012 - 2014).Expert Opin Ther Pat. 2015 Feb;25(2):209-36. DMBS2FT RU https://www.ncbi.nlm.nih.gov/pubmed/25482888 DMC82UR DI DMC82UR DMC82UR DN PMID25482888-Compound-14 DMC82UR MI TTDIGC1 DMC82UR MN Dipeptidyl peptidase 4 (DPP-4) DMC82UR MT DTT DMC82UR MA Inhibitor DMC82UR RN DPP-4 inhibitors: a patent review (2012 - 2014).Expert Opin Ther Pat. 2015 Feb;25(2):209-36. DMC82UR RU https://www.ncbi.nlm.nih.gov/pubmed/25482888 DMO913H DI DMO913H DMO913H DN PMID25482888-Compound-15 DMO913H MI TTDIGC1 DMO913H MN Dipeptidyl peptidase 4 (DPP-4) DMO913H MT DTT DMO913H MA Inhibitor DMO913H RN DPP-4 inhibitors: a patent review (2012 - 2014).Expert Opin Ther Pat. 2015 Feb;25(2):209-36. DMO913H RU https://www.ncbi.nlm.nih.gov/pubmed/25482888 DMIFVXE DI DMIFVXE DMIFVXE DN PMID25482888-Compound-16 DMIFVXE MI TTDIGC1 DMIFVXE MN Dipeptidyl peptidase 4 (DPP-4) DMIFVXE MT DTT DMIFVXE MA Inhibitor DMIFVXE RN DPP-4 inhibitors: a patent review (2012 - 2014).Expert Opin Ther Pat. 2015 Feb;25(2):209-36. DMIFVXE RU https://www.ncbi.nlm.nih.gov/pubmed/25482888 DMY4AJ7 DI DMY4AJ7 DMY4AJ7 DN PMID25482888-Compound-17 DMY4AJ7 MI TTDIGC1 DMY4AJ7 MN Dipeptidyl peptidase 4 (DPP-4) DMY4AJ7 MT DTT DMY4AJ7 MA Inhibitor DMY4AJ7 RN DPP-4 inhibitors: a patent review (2012 - 2014).Expert Opin Ther Pat. 2015 Feb;25(2):209-36. DMY4AJ7 RU https://www.ncbi.nlm.nih.gov/pubmed/25482888 DM0W5UA DI DM0W5UA DM0W5UA DN PMID25482888-Compound-18 DM0W5UA MI TTDIGC1 DM0W5UA MN Dipeptidyl peptidase 4 (DPP-4) DM0W5UA MT DTT DM0W5UA MA Inhibitor DM0W5UA RN DPP-4 inhibitors: a patent review (2012 - 2014).Expert Opin Ther Pat. 2015 Feb;25(2):209-36. DM0W5UA RU https://www.ncbi.nlm.nih.gov/pubmed/25482888 DM2W9AP DI DM2W9AP DM2W9AP DN PMID25482888-Compound-21 DM2W9AP MI TTDIGC1 DM2W9AP MN Dipeptidyl peptidase 4 (DPP-4) DM2W9AP MT DTT DM2W9AP MA Inhibitor DM2W9AP RN DPP-4 inhibitors: a patent review (2012 - 2014).Expert Opin Ther Pat. 2015 Feb;25(2):209-36. DM2W9AP RU https://www.ncbi.nlm.nih.gov/pubmed/25482888 DMX5R9N DI DMX5R9N DMX5R9N DN PMID25482888-Compound-34 DMX5R9N MI TTDIGC1 DMX5R9N MN Dipeptidyl peptidase 4 (DPP-4) DMX5R9N MT DTT DMX5R9N MA Inhibitor DMX5R9N RN DPP-4 inhibitors: a patent review (2012 - 2014).Expert Opin Ther Pat. 2015 Feb;25(2):209-36. DMX5R9N RU https://www.ncbi.nlm.nih.gov/pubmed/25482888 DMMZO8Y DI DMMZO8Y DMMZO8Y DN PMID25482888-Compound-37 DMMZO8Y MI TTDIGC1 DMMZO8Y MN Dipeptidyl peptidase 4 (DPP-4) DMMZO8Y MT DTT DMMZO8Y MA Inhibitor DMMZO8Y RN DPP-4 inhibitors: a patent review (2012 - 2014).Expert Opin Ther Pat. 2015 Feb;25(2):209-36. DMMZO8Y RU https://www.ncbi.nlm.nih.gov/pubmed/25482888 DMJOPEL DI DMJOPEL DMJOPEL DN PMID25482888-Compound-38 DMJOPEL MI TTDIGC1 DMJOPEL MN Dipeptidyl peptidase 4 (DPP-4) DMJOPEL MT DTT DMJOPEL MA Inhibitor DMJOPEL RN DPP-4 inhibitors: a patent review (2012 - 2014).Expert Opin Ther Pat. 2015 Feb;25(2):209-36. DMJOPEL RU https://www.ncbi.nlm.nih.gov/pubmed/25482888 DMMLJ5E DI DMMLJ5E DMMLJ5E DN PMID25482888-Compound-50 DMMLJ5E MI TTDIGC1 DMMLJ5E MN Dipeptidyl peptidase 4 (DPP-4) DMMLJ5E MT DTT DMMLJ5E MA Inhibitor DMMLJ5E RN DPP-4 inhibitors: a patent review (2012 - 2014).Expert Opin Ther Pat. 2015 Feb;25(2):209-36. DMMLJ5E RU https://www.ncbi.nlm.nih.gov/pubmed/25482888 DMDLPB7 DI DMDLPB7 DMDLPB7 DN PMID25482888-Compound-52 DMDLPB7 MI TTDIGC1 DMDLPB7 MN Dipeptidyl peptidase 4 (DPP-4) DMDLPB7 MT DTT DMDLPB7 MA Inhibitor DMDLPB7 RN DPP-4 inhibitors: a patent review (2012 - 2014).Expert Opin Ther Pat. 2015 Feb;25(2):209-36. DMDLPB7 RU https://www.ncbi.nlm.nih.gov/pubmed/25482888 DMB3DMR DI DMB3DMR DMB3DMR DN PMID25482888-Compound-56 DMB3DMR MI TTDIGC1 DMB3DMR MN Dipeptidyl peptidase 4 (DPP-4) DMB3DMR MT DTT DMB3DMR MA Inhibitor DMB3DMR RN DPP-4 inhibitors: a patent review (2012 - 2014).Expert Opin Ther Pat. 2015 Feb;25(2):209-36. DMB3DMR RU https://www.ncbi.nlm.nih.gov/pubmed/25482888 DM03UK2 DI DM03UK2 DM03UK2 DN PMID25482888-Compound-6 DM03UK2 MI TTDIGC1 DM03UK2 MN Dipeptidyl peptidase 4 (DPP-4) DM03UK2 MT DTT DM03UK2 MA Inhibitor DM03UK2 RN DPP-4 inhibitors: a patent review (2012 - 2014).Expert Opin Ther Pat. 2015 Feb;25(2):209-36. DM03UK2 RU https://www.ncbi.nlm.nih.gov/pubmed/25482888 DMPY8NU DI DMPY8NU DMPY8NU DN PMID25482888-Compound-69 DMPY8NU MI TTDIGC1 DMPY8NU MN Dipeptidyl peptidase 4 (DPP-4) DMPY8NU MT DTT DMPY8NU MA Inhibitor DMPY8NU RN DPP-4 inhibitors: a patent review (2012 - 2014).Expert Opin Ther Pat. 2015 Feb;25(2):209-36. DMPY8NU RU https://www.ncbi.nlm.nih.gov/pubmed/25482888 DMEYLM2 DI DMEYLM2 DMEYLM2 DN PMID25482888-Compound-70 DMEYLM2 MI TTDIGC1 DMEYLM2 MN Dipeptidyl peptidase 4 (DPP-4) DMEYLM2 MT DTT DMEYLM2 MA Inhibitor DMEYLM2 RN DPP-4 inhibitors: a patent review (2012 - 2014).Expert Opin Ther Pat. 2015 Feb;25(2):209-36. DMEYLM2 RU https://www.ncbi.nlm.nih.gov/pubmed/25482888 DMZB140 DI DMZB140 DMZB140 DN PMID25482888-Compound-71 DMZB140 MI TTDIGC1 DMZB140 MN Dipeptidyl peptidase 4 (DPP-4) DMZB140 MT DTT DMZB140 MA Inhibitor DMZB140 RN DPP-4 inhibitors: a patent review (2012 - 2014).Expert Opin Ther Pat. 2015 Feb;25(2):209-36. DMZB140 RU https://www.ncbi.nlm.nih.gov/pubmed/25482888 DMQOVKF DI DMQOVKF DMQOVKF DN PMID25482888-Compound-72 DMQOVKF MI TTDIGC1 DMQOVKF MN Dipeptidyl peptidase 4 (DPP-4) DMQOVKF MT DTT DMQOVKF MA Inhibitor DMQOVKF RN DPP-4 inhibitors: a patent review (2012 - 2014).Expert Opin Ther Pat. 2015 Feb;25(2):209-36. DMQOVKF RU https://www.ncbi.nlm.nih.gov/pubmed/25482888 DME0XS4 DI DME0XS4 DME0XS4 DN PMID25514969-Compound-10 DME0XS4 MI TT4EB85 DME0XS4 MN Cholesterol 24-hydroxylase (CYP46A1) DME0XS4 MT DTT DME0XS4 MA Inhibitor DME0XS4 RN Imidazo[1,2-a]pyridines as cholesterol 24-hydroxylase (CYP46A1) inhibitors: a patent evaluation (WO2014061676).Expert Opin Ther Pat. 2015 Mar;25(3):373-7. DME0XS4 RU https://www.ncbi.nlm.nih.gov/pubmed/25514969 DMUPL0W DI DMUPL0W DMUPL0W DN PMID25514969-Compound-11 DMUPL0W MI TT4EB85 DMUPL0W MN Cholesterol 24-hydroxylase (CYP46A1) DMUPL0W MT DTT DMUPL0W MA Inhibitor DMUPL0W RN Imidazo[1,2-a]pyridines as cholesterol 24-hydroxylase (CYP46A1) inhibitors: a patent evaluation (WO2014061676).Expert Opin Ther Pat. 2015 Mar;25(3):373-7. DMUPL0W RU https://www.ncbi.nlm.nih.gov/pubmed/25514969 DMOE5N0 DI DMOE5N0 DMOE5N0 DN PMID25514969-Compound-12 DMOE5N0 MI TT4EB85 DMOE5N0 MN Cholesterol 24-hydroxylase (CYP46A1) DMOE5N0 MT DTT DMOE5N0 MA Inhibitor DMOE5N0 RN Imidazo[1,2-a]pyridines as cholesterol 24-hydroxylase (CYP46A1) inhibitors: a patent evaluation (WO2014061676).Expert Opin Ther Pat. 2015 Mar;25(3):373-7. DMOE5N0 RU https://www.ncbi.nlm.nih.gov/pubmed/25514969 DMQB03U DI DMQB03U DMQB03U DN PMID25514969-Compound-13 DMQB03U MI TT4EB85 DMQB03U MN Cholesterol 24-hydroxylase (CYP46A1) DMQB03U MT DTT DMQB03U MA Inhibitor DMQB03U RN Imidazo[1,2-a]pyridines as cholesterol 24-hydroxylase (CYP46A1) inhibitors: a patent evaluation (WO2014061676).Expert Opin Ther Pat. 2015 Mar;25(3):373-7. DMQB03U RU https://www.ncbi.nlm.nih.gov/pubmed/25514969 DM2NVLZ DI DM2NVLZ DM2NVLZ DN PMID25514969-Compound-8 DM2NVLZ MI TT4EB85 DM2NVLZ MN Cholesterol 24-hydroxylase (CYP46A1) DM2NVLZ MT DTT DM2NVLZ MA Inhibitor DM2NVLZ RN Imidazo[1,2-a]pyridines as cholesterol 24-hydroxylase (CYP46A1) inhibitors: a patent evaluation (WO2014061676).Expert Opin Ther Pat. 2015 Mar;25(3):373-7. DM2NVLZ RU https://www.ncbi.nlm.nih.gov/pubmed/25514969 DMAEZB1 DI DMAEZB1 DMAEZB1 DN PMID25514969-Compound-9 DMAEZB1 MI TT4EB85 DMAEZB1 MN Cholesterol 24-hydroxylase (CYP46A1) DMAEZB1 MT DTT DMAEZB1 MA Inhibitor DMAEZB1 RN Imidazo[1,2-a]pyridines as cholesterol 24-hydroxylase (CYP46A1) inhibitors: a patent evaluation (WO2014061676).Expert Opin Ther Pat. 2015 Mar;25(3):373-7. DMAEZB1 RU https://www.ncbi.nlm.nih.gov/pubmed/25514969 DMC6S0W DI DMC6S0W DMC6S0W DN PMID25514969-Compound-Figure2-2 DMC6S0W MI TT4EB85 DMC6S0W MN Cholesterol 24-hydroxylase (CYP46A1) DMC6S0W MT DTT DMC6S0W MA Inhibitor DMC6S0W RN Imidazo[1,2-a]pyridines as cholesterol 24-hydroxylase (CYP46A1) inhibitors: a patent evaluation (WO2014061676).Expert Opin Ther Pat. 2015 Mar;25(3):373-7. DMC6S0W RU https://www.ncbi.nlm.nih.gov/pubmed/25514969 DMUYVOP DI DMUYVOP DMUYVOP DN PMID25514969-Compound-Figure2-3 DMUYVOP MI TT4EB85 DMUYVOP MN Cholesterol 24-hydroxylase (CYP46A1) DMUYVOP MT DTT DMUYVOP MA Inhibitor DMUYVOP RN Imidazo[1,2-a]pyridines as cholesterol 24-hydroxylase (CYP46A1) inhibitors: a patent evaluation (WO2014061676).Expert Opin Ther Pat. 2015 Mar;25(3):373-7. DMUYVOP RU https://www.ncbi.nlm.nih.gov/pubmed/25514969 DMXSAN7 DI DMXSAN7 DMXSAN7 DN PMID25514969-Compound-Figure2-4 DMXSAN7 MI TT4EB85 DMXSAN7 MN Cholesterol 24-hydroxylase (CYP46A1) DMXSAN7 MT DTT DMXSAN7 MA Inhibitor DMXSAN7 RN Imidazo[1,2-a]pyridines as cholesterol 24-hydroxylase (CYP46A1) inhibitors: a patent evaluation (WO2014061676).Expert Opin Ther Pat. 2015 Mar;25(3):373-7. DMXSAN7 RU https://www.ncbi.nlm.nih.gov/pubmed/25514969 DM7D12Y DI DM7D12Y DM7D12Y DN PMID25514969-Compound-Figure3 DM7D12Y MI TT4EB85 DM7D12Y MN Cholesterol 24-hydroxylase (CYP46A1) DM7D12Y MT DTT DM7D12Y MA Inhibitor DM7D12Y RN Imidazo[1,2-a]pyridines as cholesterol 24-hydroxylase (CYP46A1) inhibitors: a patent evaluation (WO2014061676).Expert Opin Ther Pat. 2015 Mar;25(3):373-7. DM7D12Y RU https://www.ncbi.nlm.nih.gov/pubmed/25514969 DMRJ30G DI DMRJ30G DMRJ30G DN PMID25522065-Compound-10 DMRJ30G MI TTX4RTB DMRJ30G MN Melanin-concentrating hormone receptor 1 (MCHR1) DMRJ30G MT DTT DMRJ30G MA Antagonist DMRJ30G RN Novel MCH1 receptor antagonists: a patent review.Expert Opin Ther Pat. 2015 Feb;25(2):193-207. DMRJ30G RU https://www.ncbi.nlm.nih.gov/pubmed/25522065 DM410Z6 DI DM410Z6 DM410Z6 DN PMID25522065-Compound-11 DM410Z6 MI TTX4RTB DM410Z6 MN Melanin-concentrating hormone receptor 1 (MCHR1) DM410Z6 MT DTT DM410Z6 MA Antagonist DM410Z6 RN Novel MCH1 receptor antagonists: a patent review.Expert Opin Ther Pat. 2015 Feb;25(2):193-207. DM410Z6 RU https://www.ncbi.nlm.nih.gov/pubmed/25522065 DMVKO9C DI DMVKO9C DMVKO9C DN PMID25522065-Compound-12 DMVKO9C MI TTX4RTB DMVKO9C MN Melanin-concentrating hormone receptor 1 (MCHR1) DMVKO9C MT DTT DMVKO9C MA Antagonist DMVKO9C RN Novel MCH1 receptor antagonists: a patent review.Expert Opin Ther Pat. 2015 Feb;25(2):193-207. DMVKO9C RU https://www.ncbi.nlm.nih.gov/pubmed/25522065 DM92HZG DI DM92HZG DM92HZG DN PMID25522065-Compound-13 DM92HZG MI TTX4RTB DM92HZG MN Melanin-concentrating hormone receptor 1 (MCHR1) DM92HZG MT DTT DM92HZG MA Antagonist DM92HZG RN Novel MCH1 receptor antagonists: a patent review.Expert Opin Ther Pat. 2015 Feb;25(2):193-207. DM92HZG RU https://www.ncbi.nlm.nih.gov/pubmed/25522065 DMGZER5 DI DMGZER5 DMGZER5 DN PMID25522065-Compound-14 DMGZER5 MI TTX4RTB DMGZER5 MN Melanin-concentrating hormone receptor 1 (MCHR1) DMGZER5 MT DTT DMGZER5 MA Antagonist DMGZER5 RN Novel MCH1 receptor antagonists: a patent review.Expert Opin Ther Pat. 2015 Feb;25(2):193-207. DMGZER5 RU https://www.ncbi.nlm.nih.gov/pubmed/25522065 DMZMQFW DI DMZMQFW DMZMQFW DN PMID25522065-Compound-15 DMZMQFW MI TTX4RTB DMZMQFW MN Melanin-concentrating hormone receptor 1 (MCHR1) DMZMQFW MT DTT DMZMQFW MA Antagonist DMZMQFW RN Novel MCH1 receptor antagonists: a patent review.Expert Opin Ther Pat. 2015 Feb;25(2):193-207. DMZMQFW RU https://www.ncbi.nlm.nih.gov/pubmed/25522065 DMAN3BT DI DMAN3BT DMAN3BT DN PMID25522065-Compound-16 DMAN3BT MI TTX4RTB DMAN3BT MN Melanin-concentrating hormone receptor 1 (MCHR1) DMAN3BT MT DTT DMAN3BT MA Antagonist DMAN3BT RN Novel MCH1 receptor antagonists: a patent review.Expert Opin Ther Pat. 2015 Feb;25(2):193-207. DMAN3BT RU https://www.ncbi.nlm.nih.gov/pubmed/25522065 DM7X6HR DI DM7X6HR DM7X6HR DN PMID25522065-Compound-17 DM7X6HR MI TTX4RTB DM7X6HR MN Melanin-concentrating hormone receptor 1 (MCHR1) DM7X6HR MT DTT DM7X6HR MA Antagonist DM7X6HR RN Novel MCH1 receptor antagonists: a patent review.Expert Opin Ther Pat. 2015 Feb;25(2):193-207. DM7X6HR RU https://www.ncbi.nlm.nih.gov/pubmed/25522065 DMTPJI8 DI DMTPJI8 DMTPJI8 DN PMID25522065-Compound-18 DMTPJI8 MI TTX4RTB DMTPJI8 MN Melanin-concentrating hormone receptor 1 (MCHR1) DMTPJI8 MT DTT DMTPJI8 MA Antagonist DMTPJI8 RN Novel MCH1 receptor antagonists: a patent review.Expert Opin Ther Pat. 2015 Feb;25(2):193-207. DMTPJI8 RU https://www.ncbi.nlm.nih.gov/pubmed/25522065 DMP4VYQ DI DMP4VYQ DMP4VYQ DN PMID25522065-Compound-19 DMP4VYQ MI TTX4RTB DMP4VYQ MN Melanin-concentrating hormone receptor 1 (MCHR1) DMP4VYQ MT DTT DMP4VYQ MA Antagonist DMP4VYQ RN Novel MCH1 receptor antagonists: a patent review.Expert Opin Ther Pat. 2015 Feb;25(2):193-207. DMP4VYQ RU https://www.ncbi.nlm.nih.gov/pubmed/25522065 DM3I6OF DI DM3I6OF DM3I6OF DN PMID25522065-Compound-2 DM3I6OF MI TTX4RTB DM3I6OF MN Melanin-concentrating hormone receptor 1 (MCHR1) DM3I6OF MT DTT DM3I6OF MA Antagonist DM3I6OF RN Novel MCH1 receptor antagonists: a patent review.Expert Opin Ther Pat. 2015 Feb;25(2):193-207. DM3I6OF RU https://www.ncbi.nlm.nih.gov/pubmed/25522065 DMG5J9Z DI DMG5J9Z DMG5J9Z DN PMID25522065-Compound-20 DMG5J9Z MI TTX4RTB DMG5J9Z MN Melanin-concentrating hormone receptor 1 (MCHR1) DMG5J9Z MT DTT DMG5J9Z MA Antagonist DMG5J9Z RN Novel MCH1 receptor antagonists: a patent review.Expert Opin Ther Pat. 2015 Feb;25(2):193-207. DMG5J9Z RU https://www.ncbi.nlm.nih.gov/pubmed/25522065 DMRZMH5 DI DMRZMH5 DMRZMH5 DN PMID25522065-Compound-21 DMRZMH5 MI TTX4RTB DMRZMH5 MN Melanin-concentrating hormone receptor 1 (MCHR1) DMRZMH5 MT DTT DMRZMH5 MA Antagonist DMRZMH5 RN Novel MCH1 receptor antagonists: a patent review.Expert Opin Ther Pat. 2015 Feb;25(2):193-207. DMRZMH5 RU https://www.ncbi.nlm.nih.gov/pubmed/25522065 DM1N5UH DI DM1N5UH DM1N5UH DN PMID25522065-Compound-22 DM1N5UH MI TTX4RTB DM1N5UH MN Melanin-concentrating hormone receptor 1 (MCHR1) DM1N5UH MT DTT DM1N5UH MA Antagonist DM1N5UH RN Novel MCH1 receptor antagonists: a patent review.Expert Opin Ther Pat. 2015 Feb;25(2):193-207. DM1N5UH RU https://www.ncbi.nlm.nih.gov/pubmed/25522065 DMHSGPU DI DMHSGPU DMHSGPU DN PMID25522065-Compound-23 DMHSGPU MI TTX4RTB DMHSGPU MN Melanin-concentrating hormone receptor 1 (MCHR1) DMHSGPU MT DTT DMHSGPU MA Antagonist DMHSGPU RN Novel MCH1 receptor antagonists: a patent review.Expert Opin Ther Pat. 2015 Feb;25(2):193-207. DMHSGPU RU https://www.ncbi.nlm.nih.gov/pubmed/25522065 DM9MLQ6 DI DM9MLQ6 DM9MLQ6 DN PMID25522065-Compound-24 DM9MLQ6 MI TTX4RTB DM9MLQ6 MN Melanin-concentrating hormone receptor 1 (MCHR1) DM9MLQ6 MT DTT DM9MLQ6 MA Antagonist DM9MLQ6 RN Novel MCH1 receptor antagonists: a patent review.Expert Opin Ther Pat. 2015 Feb;25(2):193-207. DM9MLQ6 RU https://www.ncbi.nlm.nih.gov/pubmed/25522065 DMUM3YW DI DMUM3YW DMUM3YW DN PMID25522065-Compound-25 DMUM3YW MI TTX4RTB DMUM3YW MN Melanin-concentrating hormone receptor 1 (MCHR1) DMUM3YW MT DTT DMUM3YW MA Antagonist DMUM3YW RN Novel MCH1 receptor antagonists: a patent review.Expert Opin Ther Pat. 2015 Feb;25(2):193-207. DMUM3YW RU https://www.ncbi.nlm.nih.gov/pubmed/25522065 DMY07NA DI DMY07NA DMY07NA DN PMID25522065-Compound-26 DMY07NA MI TTX4RTB DMY07NA MN Melanin-concentrating hormone receptor 1 (MCHR1) DMY07NA MT DTT DMY07NA MA Antagonist DMY07NA RN Novel MCH1 receptor antagonists: a patent review.Expert Opin Ther Pat. 2015 Feb;25(2):193-207. DMY07NA RU https://www.ncbi.nlm.nih.gov/pubmed/25522065 DMXN4KB DI DMXN4KB DMXN4KB DN PMID25522065-Compound-27 DMXN4KB MI TTX4RTB DMXN4KB MN Melanin-concentrating hormone receptor 1 (MCHR1) DMXN4KB MT DTT DMXN4KB MA Antagonist DMXN4KB RN Novel MCH1 receptor antagonists: a patent review.Expert Opin Ther Pat. 2015 Feb;25(2):193-207. DMXN4KB RU https://www.ncbi.nlm.nih.gov/pubmed/25522065 DMB93QU DI DMB93QU DMB93QU DN PMID25522065-Compound-28 DMB93QU MI TTX4RTB DMB93QU MN Melanin-concentrating hormone receptor 1 (MCHR1) DMB93QU MT DTT DMB93QU MA Antagonist DMB93QU RN Novel MCH1 receptor antagonists: a patent review.Expert Opin Ther Pat. 2015 Feb;25(2):193-207. DMB93QU RU https://www.ncbi.nlm.nih.gov/pubmed/25522065 DMBNAK9 DI DMBNAK9 DMBNAK9 DN PMID25522065-Compound-29 DMBNAK9 MI TTX4RTB DMBNAK9 MN Melanin-concentrating hormone receptor 1 (MCHR1) DMBNAK9 MT DTT DMBNAK9 MA Antagonist DMBNAK9 RN Novel MCH1 receptor antagonists: a patent review.Expert Opin Ther Pat. 2015 Feb;25(2):193-207. DMBNAK9 RU https://www.ncbi.nlm.nih.gov/pubmed/25522065 DM54DXT DI DM54DXT DM54DXT DN PMID25522065-Compound-3 DM54DXT MI TTX4RTB DM54DXT MN Melanin-concentrating hormone receptor 1 (MCHR1) DM54DXT MT DTT DM54DXT MA Antagonist DM54DXT RN Novel MCH1 receptor antagonists: a patent review.Expert Opin Ther Pat. 2015 Feb;25(2):193-207. DM54DXT RU https://www.ncbi.nlm.nih.gov/pubmed/25522065 DMMOV67 DI DMMOV67 DMMOV67 DN PMID25522065-Compound-30 DMMOV67 MI TTX4RTB DMMOV67 MN Melanin-concentrating hormone receptor 1 (MCHR1) DMMOV67 MT DTT DMMOV67 MA Antagonist DMMOV67 RN Novel MCH1 receptor antagonists: a patent review.Expert Opin Ther Pat. 2015 Feb;25(2):193-207. DMMOV67 RU https://www.ncbi.nlm.nih.gov/pubmed/25522065 DMEMBOW DI DMEMBOW DMEMBOW DN PMID25522065-Compound-31 DMEMBOW MI TTX4RTB DMEMBOW MN Melanin-concentrating hormone receptor 1 (MCHR1) DMEMBOW MT DTT DMEMBOW MA Antagonist DMEMBOW RN Novel MCH1 receptor antagonists: a patent review.Expert Opin Ther Pat. 2015 Feb;25(2):193-207. DMEMBOW RU https://www.ncbi.nlm.nih.gov/pubmed/25522065 DM5H3YA DI DM5H3YA DM5H3YA DN PMID25522065-Compound-32 DM5H3YA MI TTX4RTB DM5H3YA MN Melanin-concentrating hormone receptor 1 (MCHR1) DM5H3YA MT DTT DM5H3YA MA Antagonist DM5H3YA RN Novel MCH1 receptor antagonists: a patent review.Expert Opin Ther Pat. 2015 Feb;25(2):193-207. DM5H3YA RU https://www.ncbi.nlm.nih.gov/pubmed/25522065 DMYMJIW DI DMYMJIW DMYMJIW DN PMID25522065-Compound-33 DMYMJIW MI TTX4RTB DMYMJIW MN Melanin-concentrating hormone receptor 1 (MCHR1) DMYMJIW MT DTT DMYMJIW MA Antagonist DMYMJIW RN Novel MCH1 receptor antagonists: a patent review.Expert Opin Ther Pat. 2015 Feb;25(2):193-207. DMYMJIW RU https://www.ncbi.nlm.nih.gov/pubmed/25522065 DMZDIRQ DI DMZDIRQ DMZDIRQ DN PMID25522065-Compound-34 DMZDIRQ MI TTX4RTB DMZDIRQ MN Melanin-concentrating hormone receptor 1 (MCHR1) DMZDIRQ MT DTT DMZDIRQ MA Antagonist DMZDIRQ RN Novel MCH1 receptor antagonists: a patent review.Expert Opin Ther Pat. 2015 Feb;25(2):193-207. DMZDIRQ RU https://www.ncbi.nlm.nih.gov/pubmed/25522065 DM1JAFV DI DM1JAFV DM1JAFV DN PMID25522065-Compound-35 DM1JAFV MI TTX4RTB DM1JAFV MN Melanin-concentrating hormone receptor 1 (MCHR1) DM1JAFV MT DTT DM1JAFV MA Antagonist DM1JAFV RN Novel MCH1 receptor antagonists: a patent review.Expert Opin Ther Pat. 2015 Feb;25(2):193-207. DM1JAFV RU https://www.ncbi.nlm.nih.gov/pubmed/25522065 DMNISGE DI DMNISGE DMNISGE DN PMID25522065-Compound-36 DMNISGE MI TTX4RTB DMNISGE MN Melanin-concentrating hormone receptor 1 (MCHR1) DMNISGE MT DTT DMNISGE MA Antagonist DMNISGE RN Novel MCH1 receptor antagonists: a patent review.Expert Opin Ther Pat. 2015 Feb;25(2):193-207. DMNISGE RU https://www.ncbi.nlm.nih.gov/pubmed/25522065 DMH3CK0 DI DMH3CK0 DMH3CK0 DN PMID25522065-Compound-37 DMH3CK0 MI TTX4RTB DMH3CK0 MN Melanin-concentrating hormone receptor 1 (MCHR1) DMH3CK0 MT DTT DMH3CK0 MA Antagonist DMH3CK0 RN Novel MCH1 receptor antagonists: a patent review.Expert Opin Ther Pat. 2015 Feb;25(2):193-207. DMH3CK0 RU https://www.ncbi.nlm.nih.gov/pubmed/25522065 DMQLBAJ DI DMQLBAJ DMQLBAJ DN PMID25522065-Compound-38 DMQLBAJ MI TTX4RTB DMQLBAJ MN Melanin-concentrating hormone receptor 1 (MCHR1) DMQLBAJ MT DTT DMQLBAJ MA Antagonist DMQLBAJ RN Novel MCH1 receptor antagonists: a patent review.Expert Opin Ther Pat. 2015 Feb;25(2):193-207. DMQLBAJ RU https://www.ncbi.nlm.nih.gov/pubmed/25522065 DM5YMQH DI DM5YMQH DM5YMQH DN PMID25522065-Compound-39 DM5YMQH MI TTX4RTB DM5YMQH MN Melanin-concentrating hormone receptor 1 (MCHR1) DM5YMQH MT DTT DM5YMQH MA Antagonist DM5YMQH RN Novel MCH1 receptor antagonists: a patent review.Expert Opin Ther Pat. 2015 Feb;25(2):193-207. DM5YMQH RU https://www.ncbi.nlm.nih.gov/pubmed/25522065 DM84U7F DI DM84U7F DM84U7F DN PMID25522065-Compound-4 DM84U7F MI TTX4RTB DM84U7F MN Melanin-concentrating hormone receptor 1 (MCHR1) DM84U7F MT DTT DM84U7F MA Antagonist DM84U7F RN Novel MCH1 receptor antagonists: a patent review.Expert Opin Ther Pat. 2015 Feb;25(2):193-207. DM84U7F RU https://www.ncbi.nlm.nih.gov/pubmed/25522065 DMCIQ01 DI DMCIQ01 DMCIQ01 DN PMID25522065-Compound-40 DMCIQ01 MI TTX4RTB DMCIQ01 MN Melanin-concentrating hormone receptor 1 (MCHR1) DMCIQ01 MT DTT DMCIQ01 MA Antagonist DMCIQ01 RN Novel MCH1 receptor antagonists: a patent review.Expert Opin Ther Pat. 2015 Feb;25(2):193-207. DMCIQ01 RU https://www.ncbi.nlm.nih.gov/pubmed/25522065 DMWALOT DI DMWALOT DMWALOT DN PMID25522065-Compound-41 DMWALOT MI TTX4RTB DMWALOT MN Melanin-concentrating hormone receptor 1 (MCHR1) DMWALOT MT DTT DMWALOT MA Antagonist DMWALOT RN Novel MCH1 receptor antagonists: a patent review.Expert Opin Ther Pat. 2015 Feb;25(2):193-207. DMWALOT RU https://www.ncbi.nlm.nih.gov/pubmed/25522065 DMAUO6C DI DMAUO6C DMAUO6C DN PMID25522065-Compound-42 DMAUO6C MI TTX4RTB DMAUO6C MN Melanin-concentrating hormone receptor 1 (MCHR1) DMAUO6C MT DTT DMAUO6C MA Antagonist DMAUO6C RN Novel MCH1 receptor antagonists: a patent review.Expert Opin Ther Pat. 2015 Feb;25(2):193-207. DMAUO6C RU https://www.ncbi.nlm.nih.gov/pubmed/25522065 DMS1FKC DI DMS1FKC DMS1FKC DN PMID25522065-Compound-43 DMS1FKC MI TTX4RTB DMS1FKC MN Melanin-concentrating hormone receptor 1 (MCHR1) DMS1FKC MT DTT DMS1FKC MA Antagonist DMS1FKC RN Novel MCH1 receptor antagonists: a patent review.Expert Opin Ther Pat. 2015 Feb;25(2):193-207. DMS1FKC RU https://www.ncbi.nlm.nih.gov/pubmed/25522065 DMJKOFB DI DMJKOFB DMJKOFB DN PMID25522065-Compound-44 DMJKOFB MI TTX4RTB DMJKOFB MN Melanin-concentrating hormone receptor 1 (MCHR1) DMJKOFB MT DTT DMJKOFB MA Antagonist DMJKOFB RN Novel MCH1 receptor antagonists: a patent review.Expert Opin Ther Pat. 2015 Feb;25(2):193-207. DMJKOFB RU https://www.ncbi.nlm.nih.gov/pubmed/25522065 DMONJLT DI DMONJLT DMONJLT DN PMID25522065-Compound-45 DMONJLT MI TTX4RTB DMONJLT MN Melanin-concentrating hormone receptor 1 (MCHR1) DMONJLT MT DTT DMONJLT MA Antagonist DMONJLT RN Novel MCH1 receptor antagonists: a patent review.Expert Opin Ther Pat. 2015 Feb;25(2):193-207. DMONJLT RU https://www.ncbi.nlm.nih.gov/pubmed/25522065 DMBH97R DI DMBH97R DMBH97R DN PMID25522065-Compound-46 DMBH97R MI TTX4RTB DMBH97R MN Melanin-concentrating hormone receptor 1 (MCHR1) DMBH97R MT DTT DMBH97R MA Antagonist DMBH97R RN Novel MCH1 receptor antagonists: a patent review.Expert Opin Ther Pat. 2015 Feb;25(2):193-207. DMBH97R RU https://www.ncbi.nlm.nih.gov/pubmed/25522065 DMXRI5J DI DMXRI5J DMXRI5J DN PMID25522065-Compound-47 DMXRI5J MI TTX4RTB DMXRI5J MN Melanin-concentrating hormone receptor 1 (MCHR1) DMXRI5J MT DTT DMXRI5J MA Antagonist DMXRI5J RN Novel MCH1 receptor antagonists: a patent review.Expert Opin Ther Pat. 2015 Feb;25(2):193-207. DMXRI5J RU https://www.ncbi.nlm.nih.gov/pubmed/25522065 DMHI4L6 DI DMHI4L6 DMHI4L6 DN PMID25522065-Compound-48 DMHI4L6 MI TTX4RTB DMHI4L6 MN Melanin-concentrating hormone receptor 1 (MCHR1) DMHI4L6 MT DTT DMHI4L6 MA Antagonist DMHI4L6 RN Novel MCH1 receptor antagonists: a patent review.Expert Opin Ther Pat. 2015 Feb;25(2):193-207. DMHI4L6 RU https://www.ncbi.nlm.nih.gov/pubmed/25522065 DMNI03Z DI DMNI03Z DMNI03Z DN PMID25522065-Compound-49 DMNI03Z MI TTX4RTB DMNI03Z MN Melanin-concentrating hormone receptor 1 (MCHR1) DMNI03Z MT DTT DMNI03Z MA Antagonist DMNI03Z RN Novel MCH1 receptor antagonists: a patent review.Expert Opin Ther Pat. 2015 Feb;25(2):193-207. DMNI03Z RU https://www.ncbi.nlm.nih.gov/pubmed/25522065 DMA8G6B DI DMA8G6B DMA8G6B DN PMID25522065-Compound-5 DMA8G6B MI TTX4RTB DMA8G6B MN Melanin-concentrating hormone receptor 1 (MCHR1) DMA8G6B MT DTT DMA8G6B MA Antagonist DMA8G6B RN Novel MCH1 receptor antagonists: a patent review.Expert Opin Ther Pat. 2015 Feb;25(2):193-207. DMA8G6B RU https://www.ncbi.nlm.nih.gov/pubmed/25522065 DMBWA0V DI DMBWA0V DMBWA0V DN PMID25522065-Compound-50 DMBWA0V MI TTX4RTB DMBWA0V MN Melanin-concentrating hormone receptor 1 (MCHR1) DMBWA0V MT DTT DMBWA0V MA Antagonist DMBWA0V RN Novel MCH1 receptor antagonists: a patent review.Expert Opin Ther Pat. 2015 Feb;25(2):193-207. DMBWA0V RU https://www.ncbi.nlm.nih.gov/pubmed/25522065 DMEU48I DI DMEU48I DMEU48I DN PMID25522065-Compound-51 DMEU48I MI TTX4RTB DMEU48I MN Melanin-concentrating hormone receptor 1 (MCHR1) DMEU48I MT DTT DMEU48I MA Antagonist DMEU48I RN Novel MCH1 receptor antagonists: a patent review.Expert Opin Ther Pat. 2015 Feb;25(2):193-207. DMEU48I RU https://www.ncbi.nlm.nih.gov/pubmed/25522065 DMU1PEZ DI DMU1PEZ DMU1PEZ DN PMID25522065-Compound-6 DMU1PEZ MI TTX4RTB DMU1PEZ MN Melanin-concentrating hormone receptor 1 (MCHR1) DMU1PEZ MT DTT DMU1PEZ MA Antagonist DMU1PEZ RN Novel MCH1 receptor antagonists: a patent review.Expert Opin Ther Pat. 2015 Feb;25(2):193-207. DMU1PEZ RU https://www.ncbi.nlm.nih.gov/pubmed/25522065 DMYZMX6 DI DMYZMX6 DMYZMX6 DN PMID25522065-Compound-7 DMYZMX6 MI TTX4RTB DMYZMX6 MN Melanin-concentrating hormone receptor 1 (MCHR1) DMYZMX6 MT DTT DMYZMX6 MA Antagonist DMYZMX6 RN Novel MCH1 receptor antagonists: a patent review.Expert Opin Ther Pat. 2015 Feb;25(2):193-207. DMYZMX6 RU https://www.ncbi.nlm.nih.gov/pubmed/25522065 DMJMCKD DI DMJMCKD DMJMCKD DN PMID25522065-Compound-8 DMJMCKD MI TTX4RTB DMJMCKD MN Melanin-concentrating hormone receptor 1 (MCHR1) DMJMCKD MT DTT DMJMCKD MA Antagonist DMJMCKD RN Novel MCH1 receptor antagonists: a patent review.Expert Opin Ther Pat. 2015 Feb;25(2):193-207. DMJMCKD RU https://www.ncbi.nlm.nih.gov/pubmed/25522065 DMAMRPW DI DMAMRPW DMAMRPW DN PMID25522065-Compound-9 DMAMRPW MI TTX4RTB DMAMRPW MN Melanin-concentrating hormone receptor 1 (MCHR1) DMAMRPW MT DTT DMAMRPW MA Antagonist DMAMRPW RN Novel MCH1 receptor antagonists: a patent review.Expert Opin Ther Pat. 2015 Feb;25(2):193-207. DMAMRPW RU https://www.ncbi.nlm.nih.gov/pubmed/25522065 DM4GQJH DI DM4GQJH DM4GQJH DN PMID25553724-Compound-EP20132578214 2 DM4GQJH MI TTSXVID DM4GQJH MN Nuclear factor NF-kappa-B (NFKB) DM4GQJH MT DTT DM4GQJH MA Inhibitor DM4GQJH RN Novel NF-B inhibitors: a patent review (2011 - 2014).Expert Opin Ther Pat. 2015 Mar;25(3):319-34. DM4GQJH RU https://www.ncbi.nlm.nih.gov/pubmed/25553724 DMM3QEW DI DMM3QEW DMM3QEW DN PMID25553724-Compound-US2011000295210 DMM3QEW MI TTSXVID DMM3QEW MN Nuclear factor NF-kappa-B (NFKB) DMM3QEW MT DTT DMM3QEW MA Inhibitor DMM3QEW RN Novel NF-B inhibitors: a patent review (2011 - 2014).Expert Opin Ther Pat. 2015 Mar;25(3):319-34. DMM3QEW RU https://www.ncbi.nlm.nih.gov/pubmed/25553724 DMZCO6J DI DMZCO6J DMZCO6J DN PMID25553724-Compound-US2011788838110 DMZCO6J MI TTSXVID DMZCO6J MN Nuclear factor NF-kappa-B (NFKB) DMZCO6J MT DTT DMZCO6J MA Inhibitor DMZCO6J RN Novel NF-B inhibitors: a patent review (2011 - 2014).Expert Opin Ther Pat. 2015 Mar;25(3):319-34. DMZCO6J RU https://www.ncbi.nlm.nih.gov/pubmed/25553724 DMH4DMY DI DMH4DMY DMH4DMY DN PMID25553724-Compound-US2011796857710 DMH4DMY MI TTSXVID DMH4DMY MN Nuclear factor NF-kappa-B (NFKB) DMH4DMY MT DTT DMH4DMY MA Inhibitor DMH4DMY RN Novel NF-B inhibitors: a patent review (2011 - 2014).Expert Opin Ther Pat. 2015 Mar;25(3):319-34. DMH4DMY RU https://www.ncbi.nlm.nih.gov/pubmed/25553724 DMIZ64O DI DMIZ64O DMIZ64O DN PMID25553724-Compound-US2011799419010 DMIZ64O MI TTSXVID DMIZ64O MN Nuclear factor NF-kappa-B (NFKB) DMIZ64O MT DTT DMIZ64O MA Inhibitor DMIZ64O RN Novel NF-B inhibitors: a patent review (2011 - 2014).Expert Opin Ther Pat. 2015 Mar;25(3):319-34. DMIZ64O RU https://www.ncbi.nlm.nih.gov/pubmed/25553724 DMZ96CG DI DMZ96CG DMZ96CG DN PMID25553724-Compound-US2011801300410 DMZ96CG MI TTSXVID DMZ96CG MN Nuclear factor NF-kappa-B (NFKB) DMZ96CG MT DTT DMZ96CG MA Inhibitor DMZ96CG RN Novel NF-B inhibitors: a patent review (2011 - 2014).Expert Opin Ther Pat. 2015 Mar;25(3):319-34. DMZ96CG RU https://www.ncbi.nlm.nih.gov/pubmed/25553724 DMCDHZT DI DMCDHZT DMCDHZT DN PMID25553724-Compound-US2011803494010 DMCDHZT MI TTSXVID DMCDHZT MN Nuclear factor NF-kappa-B (NFKB) DMCDHZT MT DTT DMCDHZT MA Inhibitor DMCDHZT RN Novel NF-B inhibitors: a patent review (2011 - 2014).Expert Opin Ther Pat. 2015 Mar;25(3):319-34. DMCDHZT RU https://www.ncbi.nlm.nih.gov/pubmed/25553724 DMIAV5M DI DMIAV5M DMIAV5M DN PMID25553724-Compound-US2011806744710 DMIAV5M MI TTSXVID DMIAV5M MN Nuclear factor NF-kappa-B (NFKB) DMIAV5M MT DTT DMIAV5M MA Inhibitor DMIAV5M RN Novel NF-B inhibitors: a patent review (2011 - 2014).Expert Opin Ther Pat. 2015 Mar;25(3):319-34. DMIAV5M RU https://www.ncbi.nlm.nih.gov/pubmed/25553724 DM9KAF1 DI DM9KAF1 DM9KAF1 DN PMID25553724-Compound-US2012810604610 DM9KAF1 MI TTSXVID DM9KAF1 MN Nuclear factor NF-kappa-B (NFKB) DM9KAF1 MT DTT DM9KAF1 MA Inhibitor DM9KAF1 RN Novel NF-B inhibitors: a patent review (2011 - 2014).Expert Opin Ther Pat. 2015 Mar;25(3):319-34. DM9KAF1 RU https://www.ncbi.nlm.nih.gov/pubmed/25553724 DMS7RYP DI DMS7RYP DMS7RYP DN PMID25553724-Compound-US2012819831110 DMS7RYP MI TTSXVID DMS7RYP MN Nuclear factor NF-kappa-B (NFKB) DMS7RYP MT DTT DMS7RYP MA Inhibitor DMS7RYP RN Novel NF-B inhibitors: a patent review (2011 - 2014).Expert Opin Ther Pat. 2015 Mar;25(3):319-34. DMS7RYP RU https://www.ncbi.nlm.nih.gov/pubmed/25553724 DMDQ6H7 DI DMDQ6H7 DMDQ6H7 DN PMID25553724-Compound-US2012820715110 DMDQ6H7 MI TTSXVID DMDQ6H7 MN Nuclear factor NF-kappa-B (NFKB) DMDQ6H7 MT DTT DMDQ6H7 MA Inhibitor DMDQ6H7 RN Novel NF-B inhibitors: a patent review (2011 - 2014).Expert Opin Ther Pat. 2015 Mar;25(3):319-34. DMDQ6H7 RU https://www.ncbi.nlm.nih.gov/pubmed/25553724 DMCUMSV DI DMCUMSV DMCUMSV DN PMID25553724-Compound-US2012830453910 DMCUMSV MI TTSXVID DMCUMSV MN Nuclear factor NF-kappa-B (NFKB) DMCUMSV MT DTT DMCUMSV MA Inhibitor DMCUMSV RN Novel NF-B inhibitors: a patent review (2011 - 2014).Expert Opin Ther Pat. 2015 Mar;25(3):319-34. DMCUMSV RU https://www.ncbi.nlm.nih.gov/pubmed/25553724 DMFCE51 DI DMFCE51 DMFCE51 DN PMID25553724-Compound-US2012832440110 DMFCE51 MI TTSXVID DMFCE51 MN Nuclear factor NF-kappa-B (NFKB) DMFCE51 MT DTT DMFCE51 MA Inhibitor DMFCE51 RN Novel NF-B inhibitors: a patent review (2011 - 2014).Expert Opin Ther Pat. 2015 Mar;25(3):319-34. DMFCE51 RU https://www.ncbi.nlm.nih.gov/pubmed/25553724 DMUBZO3 DI DMUBZO3 DMUBZO3 DN PMID25553724-Compound-US20130116324 2 DMUBZO3 MI TTSXVID DMUBZO3 MN Nuclear factor NF-kappa-B (NFKB) DMUBZO3 MT DTT DMUBZO3 MA Inhibitor DMUBZO3 RN Novel NF-B inhibitors: a patent review (2011 - 2014).Expert Opin Ther Pat. 2015 Mar;25(3):319-34. DMUBZO3 RU https://www.ncbi.nlm.nih.gov/pubmed/25553724 DMYGB2O DI DMYGB2O DMYGB2O DN PMID25553724-Compound-US20130237529 35 DMYGB2O MI TTBP3XA DMYGB2O MN Polyubiquitin-C (UBC) DMYGB2O MT DTT DMYGB2O MA Inhibitor DMYGB2O RN Novel NF-B inhibitors: a patent review (2011 - 2014).Expert Opin Ther Pat. 2015 Mar;25(3):319-34. DMYGB2O RU https://www.ncbi.nlm.nih.gov/pubmed/25553724 DM9NGDI DI DM9NGDI DM9NGDI DN PMID25553724-Compound-US20130237529 36 DM9NGDI MI TTBP3XA DM9NGDI MN Polyubiquitin-C (UBC) DM9NGDI MT DTT DM9NGDI MA Inhibitor DM9NGDI RN Novel NF-B inhibitors: a patent review (2011 - 2014).Expert Opin Ther Pat. 2015 Mar;25(3):319-34. DM9NGDI RU https://www.ncbi.nlm.nih.gov/pubmed/25553724 DMV7SQH DI DMV7SQH DMV7SQH DN PMID25553724-Compound-US20138552206 4 DMV7SQH MI TTSXVID DMV7SQH MN Nuclear factor NF-kappa-B (NFKB) DMV7SQH MT DTT DMV7SQH MA Inhibitor DMV7SQH RN Novel NF-B inhibitors: a patent review (2011 - 2014).Expert Opin Ther Pat. 2015 Mar;25(3):319-34. DMV7SQH RU https://www.ncbi.nlm.nih.gov/pubmed/25553724 DMRVE7Z DI DMRVE7Z DMRVE7Z DN PMID25553724-Compound-US20138552206 5 DMRVE7Z MI TTSXVID DMRVE7Z MN Nuclear factor NF-kappa-B (NFKB) DMRVE7Z MT DTT DMRVE7Z MA Inhibitor DMRVE7Z RN Novel NF-B inhibitors: a patent review (2011 - 2014).Expert Opin Ther Pat. 2015 Mar;25(3):319-34. DMRVE7Z RU https://www.ncbi.nlm.nih.gov/pubmed/25553724 DM5ATIV DI DM5ATIV DM5ATIV DN PMID25553724-Compound-WO2011127048 31 DM5ATIV MI TTSXVID DM5ATIV MN Nuclear factor NF-kappa-B (NFKB) DM5ATIV MT DTT DM5ATIV MA Modulator DM5ATIV RN Novel NF-B inhibitors: a patent review (2011 - 2014).Expert Opin Ther Pat. 2015 Mar;25(3):319-34. DM5ATIV RU https://www.ncbi.nlm.nih.gov/pubmed/25553724 DMH3NOZ DI DMH3NOZ DMH3NOZ DN PMID25553724-Compound-WO2011127048 32 DMH3NOZ MI TTSXVID DMH3NOZ MN Nuclear factor NF-kappa-B (NFKB) DMH3NOZ MT DTT DMH3NOZ MA Modulator DMH3NOZ RN Novel NF-B inhibitors: a patent review (2011 - 2014).Expert Opin Ther Pat. 2015 Mar;25(3):319-34. DMH3NOZ RU https://www.ncbi.nlm.nih.gov/pubmed/25553724 DMH7496 DI DMH7496 DMH7496 DN PMID25553724-Compound-WO2011127048 33 DMH7496 MI TTSXVID DMH7496 MN Nuclear factor NF-kappa-B (NFKB) DMH7496 MT DTT DMH7496 MA Modulator DMH7496 RN Novel NF-B inhibitors: a patent review (2011 - 2014).Expert Opin Ther Pat. 2015 Mar;25(3):319-34. DMH7496 RU https://www.ncbi.nlm.nih.gov/pubmed/25553724 DM4YE8W DI DM4YE8W DM4YE8W DN PMID25553724-Compound-WO2011127048 34 DM4YE8W MI TTSXVID DM4YE8W MN Nuclear factor NF-kappa-B (NFKB) DM4YE8W MT DTT DM4YE8W MA Modulator DM4YE8W RN Novel NF-B inhibitors: a patent review (2011 - 2014).Expert Opin Ther Pat. 2015 Mar;25(3):319-34. DM4YE8W RU https://www.ncbi.nlm.nih.gov/pubmed/25553724 DMPQ175 DI DMPQ175 DMPQ175 DN PMID25553724-Compound-WO2011152671 2 DMPQ175 MI TTSXVID DMPQ175 MN Nuclear factor NF-kappa-B (NFKB) DMPQ175 MT DTT DMPQ175 MA Inhibitor DMPQ175 RN Novel NF-B inhibitors: a patent review (2011 - 2014).Expert Opin Ther Pat. 2015 Mar;25(3):319-34. DMPQ175 RU https://www.ncbi.nlm.nih.gov/pubmed/25553724 DMPFMSJ DI DMPFMSJ DMPFMSJ DN PMID25553724-Compound-WO2013082253 31 DMPFMSJ MI TTSXVID DMPFMSJ MN Nuclear factor NF-kappa-B (NFKB) DMPFMSJ MT DTT DMPFMSJ MA Modulator DMPFMSJ RN Novel NF-B inhibitors: a patent review (2011 - 2014).Expert Opin Ther Pat. 2015 Mar;25(3):319-34. DMPFMSJ RU https://www.ncbi.nlm.nih.gov/pubmed/25553724 DMXYSO1 DI DMXYSO1 DMXYSO1 DN PMID25553724-Compound-WO2013082253 32 DMXYSO1 MI TTSXVID DMXYSO1 MN Nuclear factor NF-kappa-B (NFKB) DMXYSO1 MT DTT DMXYSO1 MA Modulator DMXYSO1 RN Novel NF-B inhibitors: a patent review (2011 - 2014).Expert Opin Ther Pat. 2015 Mar;25(3):319-34. DMXYSO1 RU https://www.ncbi.nlm.nih.gov/pubmed/25553724 DMR1YH9 DI DMR1YH9 DMR1YH9 DN PMID25553724-Compound-WO2013082253 33 DMR1YH9 MI TTSXVID DMR1YH9 MN Nuclear factor NF-kappa-B (NFKB) DMR1YH9 MT DTT DMR1YH9 MA Modulator DMR1YH9 RN Novel NF-B inhibitors: a patent review (2011 - 2014).Expert Opin Ther Pat. 2015 Mar;25(3):319-34. DMR1YH9 RU https://www.ncbi.nlm.nih.gov/pubmed/25553724 DML1U69 DI DML1U69 DML1U69 DN PMID25553724-Compound-WO2013082253 34 DML1U69 MI TTSXVID DML1U69 MN Nuclear factor NF-kappa-B (NFKB) DML1U69 MT DTT DML1U69 MA Modulator DML1U69 RN Novel NF-B inhibitors: a patent review (2011 - 2014).Expert Opin Ther Pat. 2015 Mar;25(3):319-34. DML1U69 RU https://www.ncbi.nlm.nih.gov/pubmed/25553724 DMA2IMQ DI DMA2IMQ DMA2IMQ DN PMID25623274-Compound-WO2014132220C1 DMA2IMQ MI TTI2WET DMA2IMQ MN Platelet-derived growth factor receptor (PDGFR) DMA2IMQ MT DTT DMA2IMQ MA Inhibitor DMA2IMQ RN Evaluation of WO-2014132220, selective PDGFR inhibitors for the treatment of pulmonary arterial hypertension.Expert Opin Ther Pat. 2015 Apr;25(4):493-9. DMA2IMQ RU https://www.ncbi.nlm.nih.gov/pubmed/25623274 DMXEZWP DI DMXEZWP DMXEZWP DN PMID25623274-Compound-WO2014132220C2 DMXEZWP MI TTI2WET DMXEZWP MN Platelet-derived growth factor receptor (PDGFR) DMXEZWP MT DTT DMXEZWP MA Inhibitor DMXEZWP RN Evaluation of WO-2014132220, selective PDGFR inhibitors for the treatment of pulmonary arterial hypertension.Expert Opin Ther Pat. 2015 Apr;25(4):493-9. DMXEZWP RU https://www.ncbi.nlm.nih.gov/pubmed/25623274 DM8POGS DI DM8POGS DM8POGS DN PMID25656651-Compound-10 DM8POGS MI TTS7G69 DM8POGS MN Fusion protein Bcr-Abl (Bcr-Abl) DM8POGS MT DTT DM8POGS MA Inhibitor DM8POGS RN Bcr-Abl tyrosine kinase inhibitors: a patent review.Expert Opin Ther Pat. 2015 Apr;25(4):397-412. DM8POGS RU https://www.ncbi.nlm.nih.gov/pubmed/25656651 DM5ECH2 DI DM5ECH2 DM5ECH2 DN PMID25656651-Compound-11a DM5ECH2 MI TTS7G69 DM5ECH2 MN Fusion protein Bcr-Abl (Bcr-Abl) DM5ECH2 MT DTT DM5ECH2 MA Inhibitor DM5ECH2 RN Bcr-Abl tyrosine kinase inhibitors: a patent review.Expert Opin Ther Pat. 2015 Apr;25(4):397-412. DM5ECH2 RU https://www.ncbi.nlm.nih.gov/pubmed/25656651 DMP580J DI DMP580J DMP580J DN PMID25656651-Compound-11b DMP580J MI TTS7G69 DMP580J MN Fusion protein Bcr-Abl (Bcr-Abl) DMP580J MT DTT DMP580J MA Inhibitor DMP580J RN Bcr-Abl tyrosine kinase inhibitors: a patent review.Expert Opin Ther Pat. 2015 Apr;25(4):397-412. DMP580J RU https://www.ncbi.nlm.nih.gov/pubmed/25656651 DMAYINQ DI DMAYINQ DMAYINQ DN PMID25656651-Compound-11c DMAYINQ MI TTS7G69 DMAYINQ MN Fusion protein Bcr-Abl (Bcr-Abl) DMAYINQ MT DTT DMAYINQ MA Inhibitor DMAYINQ RN Bcr-Abl tyrosine kinase inhibitors: a patent review.Expert Opin Ther Pat. 2015 Apr;25(4):397-412. DMAYINQ RU https://www.ncbi.nlm.nih.gov/pubmed/25656651 DM0C9YL DI DM0C9YL DM0C9YL DN PMID25656651-Compound-15a DM0C9YL MI TTS7G69 DM0C9YL MN Fusion protein Bcr-Abl (Bcr-Abl) DM0C9YL MT DTT DM0C9YL MA Inhibitor DM0C9YL RN Bcr-Abl tyrosine kinase inhibitors: a patent review.Expert Opin Ther Pat. 2015 Apr;25(4):397-412. DM0C9YL RU https://www.ncbi.nlm.nih.gov/pubmed/25656651 DMJ4DRI DI DMJ4DRI DMJ4DRI DN PMID25656651-Compound-15b DMJ4DRI MI TTS7G69 DMJ4DRI MN Fusion protein Bcr-Abl (Bcr-Abl) DMJ4DRI MT DTT DMJ4DRI MA Inhibitor DMJ4DRI RN Bcr-Abl tyrosine kinase inhibitors: a patent review.Expert Opin Ther Pat. 2015 Apr;25(4):397-412. DMJ4DRI RU https://www.ncbi.nlm.nih.gov/pubmed/25656651 DMNK2DQ DI DMNK2DQ DMNK2DQ DN PMID25656651-Compound-15c DMNK2DQ MI TTS7G69 DMNK2DQ MN Fusion protein Bcr-Abl (Bcr-Abl) DMNK2DQ MT DTT DMNK2DQ MA Inhibitor DMNK2DQ RN Bcr-Abl tyrosine kinase inhibitors: a patent review.Expert Opin Ther Pat. 2015 Apr;25(4):397-412. DMNK2DQ RU https://www.ncbi.nlm.nih.gov/pubmed/25656651 DM9XRYU DI DM9XRYU DM9XRYU DN PMID25656651-Compound-16a DM9XRYU MI TTS7G69 DM9XRYU MN Fusion protein Bcr-Abl (Bcr-Abl) DM9XRYU MT DTT DM9XRYU MA Inhibitor DM9XRYU RN Bcr-Abl tyrosine kinase inhibitors: a patent review.Expert Opin Ther Pat. 2015 Apr;25(4):397-412. DM9XRYU RU https://www.ncbi.nlm.nih.gov/pubmed/25656651 DM5EHK2 DI DM5EHK2 DM5EHK2 DN PMID25656651-Compound-16b DM5EHK2 MI TTS7G69 DM5EHK2 MN Fusion protein Bcr-Abl (Bcr-Abl) DM5EHK2 MT DTT DM5EHK2 MA Inhibitor DM5EHK2 RN Bcr-Abl tyrosine kinase inhibitors: a patent review.Expert Opin Ther Pat. 2015 Apr;25(4):397-412. DM5EHK2 RU https://www.ncbi.nlm.nih.gov/pubmed/25656651 DMAIVEN DI DMAIVEN DMAIVEN DN PMID25656651-Compound-18 DMAIVEN MI TTS7G69 DMAIVEN MN Fusion protein Bcr-Abl (Bcr-Abl) DMAIVEN MT DTT DMAIVEN MA Inhibitor DMAIVEN RN Bcr-Abl tyrosine kinase inhibitors: a patent review.Expert Opin Ther Pat. 2015 Apr;25(4):397-412. DMAIVEN RU https://www.ncbi.nlm.nih.gov/pubmed/25656651 DMSNUVZ DI DMSNUVZ DMSNUVZ DN PMID25656651-Compound-19a DMSNUVZ MI TTS7G69 DMSNUVZ MN Fusion protein Bcr-Abl (Bcr-Abl) DMSNUVZ MT DTT DMSNUVZ MA Inhibitor DMSNUVZ RN Bcr-Abl tyrosine kinase inhibitors: a patent review.Expert Opin Ther Pat. 2015 Apr;25(4):397-412. DMSNUVZ RU https://www.ncbi.nlm.nih.gov/pubmed/25656651 DMSNUVZ DI DMSNUVZ DMSNUVZ DN PMID25656651-Compound-19a DMSNUVZ MI TTIV39N DMSNUVZ MN Fusion protein Bcr-Abl T315I mutant (Bcr-Abl T315I) DMSNUVZ MT DTT DMSNUVZ MA Inhibitor DMSNUVZ RN Bcr-Abl tyrosine kinase inhibitors: a patent review.Expert Opin Ther Pat. 2015 Apr;25(4):397-412. DMSNUVZ RU https://www.ncbi.nlm.nih.gov/pubmed/25656651 DMI1Z7D DI DMI1Z7D DMI1Z7D DN PMID25656651-Compound-19b DMI1Z7D MI TTS7G69 DMI1Z7D MN Fusion protein Bcr-Abl (Bcr-Abl) DMI1Z7D MT DTT DMI1Z7D MA Inhibitor DMI1Z7D RN Bcr-Abl tyrosine kinase inhibitors: a patent review.Expert Opin Ther Pat. 2015 Apr;25(4):397-412. DMI1Z7D RU https://www.ncbi.nlm.nih.gov/pubmed/25656651 DMI1Z7D DI DMI1Z7D DMI1Z7D DN PMID25656651-Compound-19b DMI1Z7D MI TTIV39N DMI1Z7D MN Fusion protein Bcr-Abl T315I mutant (Bcr-Abl T315I) DMI1Z7D MT DTT DMI1Z7D MA Inhibitor DMI1Z7D RN Bcr-Abl tyrosine kinase inhibitors: a patent review.Expert Opin Ther Pat. 2015 Apr;25(4):397-412. DMI1Z7D RU https://www.ncbi.nlm.nih.gov/pubmed/25656651 DM7R2X0 DI DM7R2X0 DM7R2X0 DN PMID25656651-Compound-20a DM7R2X0 MI TTS7G69 DM7R2X0 MN Fusion protein Bcr-Abl (Bcr-Abl) DM7R2X0 MT DTT DM7R2X0 MA Inhibitor DM7R2X0 RN Bcr-Abl tyrosine kinase inhibitors: a patent review.Expert Opin Ther Pat. 2015 Apr;25(4):397-412. DM7R2X0 RU https://www.ncbi.nlm.nih.gov/pubmed/25656651 DMLUFB2 DI DMLUFB2 DMLUFB2 DN PMID25656651-Compound-20b DMLUFB2 MI TTS7G69 DMLUFB2 MN Fusion protein Bcr-Abl (Bcr-Abl) DMLUFB2 MT DTT DMLUFB2 MA Inhibitor DMLUFB2 RN Bcr-Abl tyrosine kinase inhibitors: a patent review.Expert Opin Ther Pat. 2015 Apr;25(4):397-412. DMLUFB2 RU https://www.ncbi.nlm.nih.gov/pubmed/25656651 DMCKAON DI DMCKAON DMCKAON DN PMID25656651-Compound-21a DMCKAON MI TTS7G69 DMCKAON MN Fusion protein Bcr-Abl (Bcr-Abl) DMCKAON MT DTT DMCKAON MA Inhibitor DMCKAON RN Bcr-Abl tyrosine kinase inhibitors: a patent review.Expert Opin Ther Pat. 2015 Apr;25(4):397-412. DMCKAON RU https://www.ncbi.nlm.nih.gov/pubmed/25656651 DMCKAON DI DMCKAON DMCKAON DN PMID25656651-Compound-21a DMCKAON MI TTI7421 DMCKAON MN Platelet-derived growth factor receptor beta (PDGFRB) DMCKAON MT DTT DMCKAON MA Inhibitor DMCKAON RN Bcr-Abl tyrosine kinase inhibitors: a patent review.Expert Opin Ther Pat. 2015 Apr;25(4):397-412. DMCKAON RU https://www.ncbi.nlm.nih.gov/pubmed/25656651 DMCKAON DI DMCKAON DMCKAON DN PMID25656651-Compound-21a DMCKAON MI TTX41N9 DMCKAON MN Tyrosine-protein kinase Kit (KIT) DMCKAON MT DTT DMCKAON MA Inhibitor DMCKAON RN Bcr-Abl tyrosine kinase inhibitors: a patent review.Expert Opin Ther Pat. 2015 Apr;25(4):397-412. DMCKAON RU https://www.ncbi.nlm.nih.gov/pubmed/25656651 DMVABXI DI DMVABXI DMVABXI DN PMID25656651-Compound-21b DMVABXI MI TTS7G69 DMVABXI MN Fusion protein Bcr-Abl (Bcr-Abl) DMVABXI MT DTT DMVABXI MA Inhibitor DMVABXI RN Bcr-Abl tyrosine kinase inhibitors: a patent review.Expert Opin Ther Pat. 2015 Apr;25(4):397-412. DMVABXI RU https://www.ncbi.nlm.nih.gov/pubmed/25656651 DMVABXI DI DMVABXI DMVABXI DN PMID25656651-Compound-21b DMVABXI MI TTI7421 DMVABXI MN Platelet-derived growth factor receptor beta (PDGFRB) DMVABXI MT DTT DMVABXI MA Inhibitor DMVABXI RN Bcr-Abl tyrosine kinase inhibitors: a patent review.Expert Opin Ther Pat. 2015 Apr;25(4):397-412. DMVABXI RU https://www.ncbi.nlm.nih.gov/pubmed/25656651 DMVABXI DI DMVABXI DMVABXI DN PMID25656651-Compound-21b DMVABXI MI TTX41N9 DMVABXI MN Tyrosine-protein kinase Kit (KIT) DMVABXI MT DTT DMVABXI MA Inhibitor DMVABXI RN Bcr-Abl tyrosine kinase inhibitors: a patent review.Expert Opin Ther Pat. 2015 Apr;25(4):397-412. DMVABXI RU https://www.ncbi.nlm.nih.gov/pubmed/25656651 DMZUB3D DI DMZUB3D DMZUB3D DN PMID25656651-Compound-23a DMZUB3D MI TTS7G69 DMZUB3D MN Fusion protein Bcr-Abl (Bcr-Abl) DMZUB3D MT DTT DMZUB3D MA Inhibitor DMZUB3D RN Bcr-Abl tyrosine kinase inhibitors: a patent review.Expert Opin Ther Pat. 2015 Apr;25(4):397-412. DMZUB3D RU https://www.ncbi.nlm.nih.gov/pubmed/25656651 DMTOFGH DI DMTOFGH DMTOFGH DN PMID25656651-Compound-23b DMTOFGH MI TTS7G69 DMTOFGH MN Fusion protein Bcr-Abl (Bcr-Abl) DMTOFGH MT DTT DMTOFGH MA Inhibitor DMTOFGH RN Bcr-Abl tyrosine kinase inhibitors: a patent review.Expert Opin Ther Pat. 2015 Apr;25(4):397-412. DMTOFGH RU https://www.ncbi.nlm.nih.gov/pubmed/25656651 DMLTR9E DI DMLTR9E DMLTR9E DN PMID25656651-Compound-23c DMLTR9E MI TTS7G69 DMLTR9E MN Fusion protein Bcr-Abl (Bcr-Abl) DMLTR9E MT DTT DMLTR9E MA Inhibitor DMLTR9E RN Bcr-Abl tyrosine kinase inhibitors: a patent review.Expert Opin Ther Pat. 2015 Apr;25(4):397-412. DMLTR9E RU https://www.ncbi.nlm.nih.gov/pubmed/25656651 DMAYSNQ DI DMAYSNQ DMAYSNQ DN PMID25656651-Compound-25 DMAYSNQ MI TTS7G69 DMAYSNQ MN Fusion protein Bcr-Abl (Bcr-Abl) DMAYSNQ MT DTT DMAYSNQ MA Inhibitor DMAYSNQ RN Bcr-Abl tyrosine kinase inhibitors: a patent review.Expert Opin Ther Pat. 2015 Apr;25(4):397-412. DMAYSNQ RU https://www.ncbi.nlm.nih.gov/pubmed/25656651 DMXM98J DI DMXM98J DMXM98J DN PMID25656651-Compound-26a DMXM98J MI TTS7G69 DMXM98J MN Fusion protein Bcr-Abl (Bcr-Abl) DMXM98J MT DTT DMXM98J MA Inhibitor DMXM98J RN Bcr-Abl tyrosine kinase inhibitors: a patent review.Expert Opin Ther Pat. 2015 Apr;25(4):397-412. DMXM98J RU https://www.ncbi.nlm.nih.gov/pubmed/25656651 DMWG95Z DI DMWG95Z DMWG95Z DN PMID25656651-Compound-26b DMWG95Z MI TTS7G69 DMWG95Z MN Fusion protein Bcr-Abl (Bcr-Abl) DMWG95Z MT DTT DMWG95Z MA Inhibitor DMWG95Z RN Bcr-Abl tyrosine kinase inhibitors: a patent review.Expert Opin Ther Pat. 2015 Apr;25(4):397-412. DMWG95Z RU https://www.ncbi.nlm.nih.gov/pubmed/25656651 DMR7A58 DI DMR7A58 DMR7A58 DN PMID25656651-Compound-26c DMR7A58 MI TTS7G69 DMR7A58 MN Fusion protein Bcr-Abl (Bcr-Abl) DMR7A58 MT DTT DMR7A58 MA Inhibitor DMR7A58 RN Bcr-Abl tyrosine kinase inhibitors: a patent review.Expert Opin Ther Pat. 2015 Apr;25(4):397-412. DMR7A58 RU https://www.ncbi.nlm.nih.gov/pubmed/25656651 DMXK43O DI DMXK43O DMXK43O DN PMID25656651-Compound-27 DMXK43O MI TTS7G69 DMXK43O MN Fusion protein Bcr-Abl (Bcr-Abl) DMXK43O MT DTT DMXK43O MA Inhibitor DMXK43O RN Bcr-Abl tyrosine kinase inhibitors: a patent review.Expert Opin Ther Pat. 2015 Apr;25(4):397-412. DMXK43O RU https://www.ncbi.nlm.nih.gov/pubmed/25656651 DM06LDV DI DM06LDV DM06LDV DN PMID25656651-Compound-28a DM06LDV MI TT3PJMV DM06LDV MN Tyrosine-protein kinase ABL1 (ABL) DM06LDV MT DTT DM06LDV MA Inhibitor DM06LDV RN Bcr-Abl tyrosine kinase inhibitors: a patent review.Expert Opin Ther Pat. 2015 Apr;25(4):397-412. DM06LDV RU https://www.ncbi.nlm.nih.gov/pubmed/25656651 DMKB7XV DI DMKB7XV DMKB7XV DN PMID25656651-Compound-28b DMKB7XV MI TT3PJMV DMKB7XV MN Tyrosine-protein kinase ABL1 (ABL) DMKB7XV MT DTT DMKB7XV MA Inhibitor DMKB7XV RN Bcr-Abl tyrosine kinase inhibitors: a patent review.Expert Opin Ther Pat. 2015 Apr;25(4):397-412. DMKB7XV RU https://www.ncbi.nlm.nih.gov/pubmed/25656651 DMCEST4 DI DMCEST4 DMCEST4 DN PMID25656651-Compound-29a DMCEST4 MI TTS7G69 DMCEST4 MN Fusion protein Bcr-Abl (Bcr-Abl) DMCEST4 MT DTT DMCEST4 MA Inhibitor DMCEST4 RN Bcr-Abl tyrosine kinase inhibitors: a patent review.Expert Opin Ther Pat. 2015 Apr;25(4):397-412. DMCEST4 RU https://www.ncbi.nlm.nih.gov/pubmed/25656651 DMBKRY7 DI DMBKRY7 DMBKRY7 DN PMID25656651-Compound-29b DMBKRY7 MI TTS7G69 DMBKRY7 MN Fusion protein Bcr-Abl (Bcr-Abl) DMBKRY7 MT DTT DMBKRY7 MA Inhibitor DMBKRY7 RN Bcr-Abl tyrosine kinase inhibitors: a patent review.Expert Opin Ther Pat. 2015 Apr;25(4):397-412. DMBKRY7 RU https://www.ncbi.nlm.nih.gov/pubmed/25656651 DMVMSQ2 DI DMVMSQ2 DMVMSQ2 DN PMID25656651-Compound-30a DMVMSQ2 MI TTS7G69 DMVMSQ2 MN Fusion protein Bcr-Abl (Bcr-Abl) DMVMSQ2 MT DTT DMVMSQ2 MA Inhibitor DMVMSQ2 RN Bcr-Abl tyrosine kinase inhibitors: a patent review.Expert Opin Ther Pat. 2015 Apr;25(4):397-412. DMVMSQ2 RU https://www.ncbi.nlm.nih.gov/pubmed/25656651 DMEJMPD DI DMEJMPD DMEJMPD DN PMID25656651-Compound-30b DMEJMPD MI TTS7G69 DMEJMPD MN Fusion protein Bcr-Abl (Bcr-Abl) DMEJMPD MT DTT DMEJMPD MA Inhibitor DMEJMPD RN Bcr-Abl tyrosine kinase inhibitors: a patent review.Expert Opin Ther Pat. 2015 Apr;25(4):397-412. DMEJMPD RU https://www.ncbi.nlm.nih.gov/pubmed/25656651 DMSVQMO DI DMSVQMO DMSVQMO DN PMID25656651-Compound-31a DMSVQMO MI TTIV39N DMSVQMO MN Fusion protein Bcr-Abl T315I mutant (Bcr-Abl T315I) DMSVQMO MT DTT DMSVQMO MA Inhibitor DMSVQMO RN Bcr-Abl tyrosine kinase inhibitors: a patent review.Expert Opin Ther Pat. 2015 Apr;25(4):397-412. DMSVQMO RU https://www.ncbi.nlm.nih.gov/pubmed/25656651 DM6TGUR DI DM6TGUR DM6TGUR DN PMID25656651-Compound-31b DM6TGUR MI TTIV39N DM6TGUR MN Fusion protein Bcr-Abl T315I mutant (Bcr-Abl T315I) DM6TGUR MT DTT DM6TGUR MA Inhibitor DM6TGUR RN Bcr-Abl tyrosine kinase inhibitors: a patent review.Expert Opin Ther Pat. 2015 Apr;25(4):397-412. DM6TGUR RU https://www.ncbi.nlm.nih.gov/pubmed/25656651 DMDJGPC DI DMDJGPC DMDJGPC DN PMID25656651-Compound-31c DMDJGPC MI TTIV39N DMDJGPC MN Fusion protein Bcr-Abl T315I mutant (Bcr-Abl T315I) DMDJGPC MT DTT DMDJGPC MA Inhibitor DMDJGPC RN Bcr-Abl tyrosine kinase inhibitors: a patent review.Expert Opin Ther Pat. 2015 Apr;25(4):397-412. DMDJGPC RU https://www.ncbi.nlm.nih.gov/pubmed/25656651 DMCRA2U DI DMCRA2U DMCRA2U DN PMID25656651-Compound-33a DMCRA2U MI TT3PJMV DMCRA2U MN Tyrosine-protein kinase ABL1 (ABL) DMCRA2U MT DTT DMCRA2U MA Inhibitor DMCRA2U RN Bcr-Abl tyrosine kinase inhibitors: a patent review.Expert Opin Ther Pat. 2015 Apr;25(4):397-412. DMCRA2U RU https://www.ncbi.nlm.nih.gov/pubmed/25656651 DMU8ZI3 DI DMU8ZI3 DMU8ZI3 DN PMID25656651-Compound-33b DMU8ZI3 MI TT3PJMV DMU8ZI3 MN Tyrosine-protein kinase ABL1 (ABL) DMU8ZI3 MT DTT DMU8ZI3 MA Inhibitor DMU8ZI3 RN Bcr-Abl tyrosine kinase inhibitors: a patent review.Expert Opin Ther Pat. 2015 Apr;25(4):397-412. DMU8ZI3 RU https://www.ncbi.nlm.nih.gov/pubmed/25656651 DMWOR8B DI DMWOR8B DMWOR8B DN PMID25656651-Compound-34a DMWOR8B MI TT3PJMV DMWOR8B MN Tyrosine-protein kinase ABL1 (ABL) DMWOR8B MT DTT DMWOR8B MA Inhibitor DMWOR8B RN Bcr-Abl tyrosine kinase inhibitors: a patent review.Expert Opin Ther Pat. 2015 Apr;25(4):397-412. DMWOR8B RU https://www.ncbi.nlm.nih.gov/pubmed/25656651 DMBD706 DI DMBD706 DMBD706 DN PMID25656651-Compound-34b DMBD706 MI TT3PJMV DMBD706 MN Tyrosine-protein kinase ABL1 (ABL) DMBD706 MT DTT DMBD706 MA Inhibitor DMBD706 RN Bcr-Abl tyrosine kinase inhibitors: a patent review.Expert Opin Ther Pat. 2015 Apr;25(4):397-412. DMBD706 RU https://www.ncbi.nlm.nih.gov/pubmed/25656651 DMG5I41 DI DMG5I41 DMG5I41 DN PMID25656651-Compound-34c DMG5I41 MI TT3PJMV DMG5I41 MN Tyrosine-protein kinase ABL1 (ABL) DMG5I41 MT DTT DMG5I41 MA Inhibitor DMG5I41 RN Bcr-Abl tyrosine kinase inhibitors: a patent review.Expert Opin Ther Pat. 2015 Apr;25(4):397-412. DMG5I41 RU https://www.ncbi.nlm.nih.gov/pubmed/25656651 DMNXVY9 DI DMNXVY9 DMNXVY9 DN PMID25656651-Compound-36a DMNXVY9 MI TTS7G69 DMNXVY9 MN Fusion protein Bcr-Abl (Bcr-Abl) DMNXVY9 MT DTT DMNXVY9 MA Inhibitor DMNXVY9 RN Bcr-Abl tyrosine kinase inhibitors: a patent review.Expert Opin Ther Pat. 2015 Apr;25(4):397-412. DMNXVY9 RU https://www.ncbi.nlm.nih.gov/pubmed/25656651 DMNXVY9 DI DMNXVY9 DMNXVY9 DN PMID25656651-Compound-36a DMNXVY9 MI TTIV39N DMNXVY9 MN Fusion protein Bcr-Abl T315I mutant (Bcr-Abl T315I) DMNXVY9 MT DTT DMNXVY9 MA Inhibitor DMNXVY9 RN Bcr-Abl tyrosine kinase inhibitors: a patent review.Expert Opin Ther Pat. 2015 Apr;25(4):397-412. DMNXVY9 RU https://www.ncbi.nlm.nih.gov/pubmed/25656651 DMHYDM7 DI DMHYDM7 DMHYDM7 DN PMID25656651-Compound-36b DMHYDM7 MI TTS7G69 DMHYDM7 MN Fusion protein Bcr-Abl (Bcr-Abl) DMHYDM7 MT DTT DMHYDM7 MA Inhibitor DMHYDM7 RN Bcr-Abl tyrosine kinase inhibitors: a patent review.Expert Opin Ther Pat. 2015 Apr;25(4):397-412. DMHYDM7 RU https://www.ncbi.nlm.nih.gov/pubmed/25656651 DMHYDM7 DI DMHYDM7 DMHYDM7 DN PMID25656651-Compound-36b DMHYDM7 MI TTIV39N DMHYDM7 MN Fusion protein Bcr-Abl T315I mutant (Bcr-Abl T315I) DMHYDM7 MT DTT DMHYDM7 MA Inhibitor DMHYDM7 RN Bcr-Abl tyrosine kinase inhibitors: a patent review.Expert Opin Ther Pat. 2015 Apr;25(4):397-412. DMHYDM7 RU https://www.ncbi.nlm.nih.gov/pubmed/25656651 DMOGKSW DI DMOGKSW DMOGKSW DN PMID25656651-Compound-36c DMOGKSW MI TTS7G69 DMOGKSW MN Fusion protein Bcr-Abl (Bcr-Abl) DMOGKSW MT DTT DMOGKSW MA Inhibitor DMOGKSW RN Bcr-Abl tyrosine kinase inhibitors: a patent review.Expert Opin Ther Pat. 2015 Apr;25(4):397-412. DMOGKSW RU https://www.ncbi.nlm.nih.gov/pubmed/25656651 DMOGKSW DI DMOGKSW DMOGKSW DN PMID25656651-Compound-36c DMOGKSW MI TTIV39N DMOGKSW MN Fusion protein Bcr-Abl T315I mutant (Bcr-Abl T315I) DMOGKSW MT DTT DMOGKSW MA Inhibitor DMOGKSW RN Bcr-Abl tyrosine kinase inhibitors: a patent review.Expert Opin Ther Pat. 2015 Apr;25(4):397-412. DMOGKSW RU https://www.ncbi.nlm.nih.gov/pubmed/25656651 DMKMY4I DI DMKMY4I DMKMY4I DN PMID25656651-Compound-36d DMKMY4I MI TTS7G69 DMKMY4I MN Fusion protein Bcr-Abl (Bcr-Abl) DMKMY4I MT DTT DMKMY4I MA Inhibitor DMKMY4I RN Bcr-Abl tyrosine kinase inhibitors: a patent review.Expert Opin Ther Pat. 2015 Apr;25(4):397-412. DMKMY4I RU https://www.ncbi.nlm.nih.gov/pubmed/25656651 DMKMY4I DI DMKMY4I DMKMY4I DN PMID25656651-Compound-36d DMKMY4I MI TTIV39N DMKMY4I MN Fusion protein Bcr-Abl T315I mutant (Bcr-Abl T315I) DMKMY4I MT DTT DMKMY4I MA Inhibitor DMKMY4I RN Bcr-Abl tyrosine kinase inhibitors: a patent review.Expert Opin Ther Pat. 2015 Apr;25(4):397-412. DMKMY4I RU https://www.ncbi.nlm.nih.gov/pubmed/25656651 DM0P4F3 DI DM0P4F3 DM0P4F3 DN PMID25656651-Compound-37a DM0P4F3 MI TTS7G69 DM0P4F3 MN Fusion protein Bcr-Abl (Bcr-Abl) DM0P4F3 MT DTT DM0P4F3 MA Inhibitor DM0P4F3 RN Bcr-Abl tyrosine kinase inhibitors: a patent review.Expert Opin Ther Pat. 2015 Apr;25(4):397-412. DM0P4F3 RU https://www.ncbi.nlm.nih.gov/pubmed/25656651 DM0P4F3 DI DM0P4F3 DM0P4F3 DN PMID25656651-Compound-37a DM0P4F3 MI TTIV39N DM0P4F3 MN Fusion protein Bcr-Abl T315I mutant (Bcr-Abl T315I) DM0P4F3 MT DTT DM0P4F3 MA Inhibitor DM0P4F3 RN Bcr-Abl tyrosine kinase inhibitors: a patent review.Expert Opin Ther Pat. 2015 Apr;25(4):397-412. DM0P4F3 RU https://www.ncbi.nlm.nih.gov/pubmed/25656651 DMX98YV DI DMX98YV DMX98YV DN PMID25656651-Compound-37b DMX98YV MI TTS7G69 DMX98YV MN Fusion protein Bcr-Abl (Bcr-Abl) DMX98YV MT DTT DMX98YV MA Inhibitor DMX98YV RN Bcr-Abl tyrosine kinase inhibitors: a patent review.Expert Opin Ther Pat. 2015 Apr;25(4):397-412. DMX98YV RU https://www.ncbi.nlm.nih.gov/pubmed/25656651 DMX98YV DI DMX98YV DMX98YV DN PMID25656651-Compound-37b DMX98YV MI TTIV39N DMX98YV MN Fusion protein Bcr-Abl T315I mutant (Bcr-Abl T315I) DMX98YV MT DTT DMX98YV MA Inhibitor DMX98YV RN Bcr-Abl tyrosine kinase inhibitors: a patent review.Expert Opin Ther Pat. 2015 Apr;25(4):397-412. DMX98YV RU https://www.ncbi.nlm.nih.gov/pubmed/25656651 DM684IK DI DM684IK DM684IK DN PMID25656651-Compound-37c DM684IK MI TTS7G69 DM684IK MN Fusion protein Bcr-Abl (Bcr-Abl) DM684IK MT DTT DM684IK MA Inhibitor DM684IK RN Bcr-Abl tyrosine kinase inhibitors: a patent review.Expert Opin Ther Pat. 2015 Apr;25(4):397-412. DM684IK RU https://www.ncbi.nlm.nih.gov/pubmed/25656651 DM684IK DI DM684IK DM684IK DN PMID25656651-Compound-37c DM684IK MI TTIV39N DM684IK MN Fusion protein Bcr-Abl T315I mutant (Bcr-Abl T315I) DM684IK MT DTT DM684IK MA Inhibitor DM684IK RN Bcr-Abl tyrosine kinase inhibitors: a patent review.Expert Opin Ther Pat. 2015 Apr;25(4):397-412. DM684IK RU https://www.ncbi.nlm.nih.gov/pubmed/25656651 DMECOY7 DI DMECOY7 DMECOY7 DN PMID25656651-Compound-38 DMECOY7 MI TTS7G69 DMECOY7 MN Fusion protein Bcr-Abl (Bcr-Abl) DMECOY7 MT DTT DMECOY7 MA Inhibitor DMECOY7 RN Bcr-Abl tyrosine kinase inhibitors: a patent review.Expert Opin Ther Pat. 2015 Apr;25(4):397-412. DMECOY7 RU https://www.ncbi.nlm.nih.gov/pubmed/25656651 DMLGD52 DI DMLGD52 DMLGD52 DN PMID25656651-Compound-40 DMLGD52 MI TTS7G69 DMLGD52 MN Fusion protein Bcr-Abl (Bcr-Abl) DMLGD52 MT DTT DMLGD52 MA Inhibitor DMLGD52 RN Bcr-Abl tyrosine kinase inhibitors: a patent review.Expert Opin Ther Pat. 2015 Apr;25(4):397-412. DMLGD52 RU https://www.ncbi.nlm.nih.gov/pubmed/25656651 DMTUA6E DI DMTUA6E DMTUA6E DN PMID25656651-Compound-42 DMTUA6E MI TTZJTWA DMTUA6E MN ABL T315I mutant (ABL T315I) DMTUA6E MT DTT DMTUA6E MA Inhibitor DMTUA6E RN Bcr-Abl tyrosine kinase inhibitors: a patent review.Expert Opin Ther Pat. 2015 Apr;25(4):397-412. DMTUA6E RU https://www.ncbi.nlm.nih.gov/pubmed/25656651 DMTUA6E DI DMTUA6E DMTUA6E DN PMID25656651-Compound-42 DMTUA6E MI TT3PJMV DMTUA6E MN Tyrosine-protein kinase ABL1 (ABL) DMTUA6E MT DTT DMTUA6E MA Inhibitor DMTUA6E RN Bcr-Abl tyrosine kinase inhibitors: a patent review.Expert Opin Ther Pat. 2015 Apr;25(4):397-412. DMTUA6E RU https://www.ncbi.nlm.nih.gov/pubmed/25656651 DM7XQUT DI DM7XQUT DM7XQUT DN PMID25656651-Compound-46 DM7XQUT MI TT3PJMV DM7XQUT MN Tyrosine-protein kinase ABL1 (ABL) DM7XQUT MT DTT DM7XQUT MA Inhibitor DM7XQUT RN Bcr-Abl tyrosine kinase inhibitors: a patent review.Expert Opin Ther Pat. 2015 Apr;25(4):397-412. DM7XQUT RU https://www.ncbi.nlm.nih.gov/pubmed/25656651 DMAI95U DI DMAI95U DMAI95U DN PMID25656651-Compound-5 DMAI95U MI TTS7G69 DMAI95U MN Fusion protein Bcr-Abl (Bcr-Abl) DMAI95U MT DTT DMAI95U MA Inhibitor DMAI95U RN Bcr-Abl tyrosine kinase inhibitors: a patent review.Expert Opin Ther Pat. 2015 Apr;25(4):397-412. DMAI95U RU https://www.ncbi.nlm.nih.gov/pubmed/25656651 DMK3TMD DI DMK3TMD DMK3TMD DN PMID25656651-Compound-7 DMK3TMD MI TTS7G69 DMK3TMD MN Fusion protein Bcr-Abl (Bcr-Abl) DMK3TMD MT DTT DMK3TMD MA Inhibitor DMK3TMD RN Bcr-Abl tyrosine kinase inhibitors: a patent review.Expert Opin Ther Pat. 2015 Apr;25(4):397-412. DMK3TMD RU https://www.ncbi.nlm.nih.gov/pubmed/25656651 DMEL1WX DI DMEL1WX DMEL1WX DN PMID25666693-Compound-1 DMEL1WX MI TTMI6F5 DMEL1WX MN Transient receptor potential cation channel V1 (TRPV1) DMEL1WX MT DTT DMEL1WX MA Antagonist DMEL1WX RN Transient receptor potential vanilloid type 1 antagonists: a patent review (2011 - 2014).Expert Opin Ther Pat. 2015 Mar;25(3):291-318. DMEL1WX RU https://www.ncbi.nlm.nih.gov/pubmed/25666693 DMQP3TD DI DMQP3TD DMQP3TD DN PMID25666693-Compound-10 DMQP3TD MI TTMI6F5 DMQP3TD MN Transient receptor potential cation channel V1 (TRPV1) DMQP3TD MT DTT DMQP3TD MA Antagonist DMQP3TD RN Transient receptor potential vanilloid type 1 antagonists: a patent review (2011 - 2014).Expert Opin Ther Pat. 2015 Mar;25(3):291-318. DMQP3TD RU https://www.ncbi.nlm.nih.gov/pubmed/25666693 DMYTZFP DI DMYTZFP DMYTZFP DN PMID25666693-Compound-100 DMYTZFP MI TTMI6F5 DMYTZFP MN Transient receptor potential cation channel V1 (TRPV1) DMYTZFP MT DTT DMYTZFP MA Antagonist DMYTZFP RN Transient receptor potential vanilloid type 1 antagonists: a patent review (2011 - 2014).Expert Opin Ther Pat. 2015 Mar;25(3):291-318. DMYTZFP RU https://www.ncbi.nlm.nih.gov/pubmed/25666693 DMNOD4A DI DMNOD4A DMNOD4A DN PMID25666693-Compound-101 DMNOD4A MI TTMI6F5 DMNOD4A MN Transient receptor potential cation channel V1 (TRPV1) DMNOD4A MT DTT DMNOD4A MA Antagonist DMNOD4A RN Transient receptor potential vanilloid type 1 antagonists: a patent review (2011 - 2014).Expert Opin Ther Pat. 2015 Mar;25(3):291-318. DMNOD4A RU https://www.ncbi.nlm.nih.gov/pubmed/25666693 DM0OY5D DI DM0OY5D DM0OY5D DN PMID25666693-Compound-102 DM0OY5D MI TTMI6F5 DM0OY5D MN Transient receptor potential cation channel V1 (TRPV1) DM0OY5D MT DTT DM0OY5D MA Antagonist DM0OY5D RN Transient receptor potential vanilloid type 1 antagonists: a patent review (2011 - 2014).Expert Opin Ther Pat. 2015 Mar;25(3):291-318. DM0OY5D RU https://www.ncbi.nlm.nih.gov/pubmed/25666693 DM8DZA6 DI DM8DZA6 DM8DZA6 DN PMID25666693-Compound-103 DM8DZA6 MI TTMI6F5 DM8DZA6 MN Transient receptor potential cation channel V1 (TRPV1) DM8DZA6 MT DTT DM8DZA6 MA Antagonist DM8DZA6 RN Transient receptor potential vanilloid type 1 antagonists: a patent review (2011 - 2014).Expert Opin Ther Pat. 2015 Mar;25(3):291-318. DM8DZA6 RU https://www.ncbi.nlm.nih.gov/pubmed/25666693 DMYCT5B DI DMYCT5B DMYCT5B DN PMID25666693-Compound-104 DMYCT5B MI TTMI6F5 DMYCT5B MN Transient receptor potential cation channel V1 (TRPV1) DMYCT5B MT DTT DMYCT5B MA Antagonist DMYCT5B RN Transient receptor potential vanilloid type 1 antagonists: a patent review (2011 - 2014).Expert Opin Ther Pat. 2015 Mar;25(3):291-318. DMYCT5B RU https://www.ncbi.nlm.nih.gov/pubmed/25666693 DMV509A DI DMV509A DMV509A DN PMID25666693-Compound-105 DMV509A MI TTMI6F5 DMV509A MN Transient receptor potential cation channel V1 (TRPV1) DMV509A MT DTT DMV509A MA Antagonist DMV509A RN Transient receptor potential vanilloid type 1 antagonists: a patent review (2011 - 2014).Expert Opin Ther Pat. 2015 Mar;25(3):291-318. DMV509A RU https://www.ncbi.nlm.nih.gov/pubmed/25666693 DMEG8CB DI DMEG8CB DMEG8CB DN PMID25666693-Compound-106 DMEG8CB MI TTMI6F5 DMEG8CB MN Transient receptor potential cation channel V1 (TRPV1) DMEG8CB MT DTT DMEG8CB MA Antagonist DMEG8CB RN Transient receptor potential vanilloid type 1 antagonists: a patent review (2011 - 2014).Expert Opin Ther Pat. 2015 Mar;25(3):291-318. DMEG8CB RU https://www.ncbi.nlm.nih.gov/pubmed/25666693 DMB2RML DI DMB2RML DMB2RML DN PMID25666693-Compound-107 DMB2RML MI TTMI6F5 DMB2RML MN Transient receptor potential cation channel V1 (TRPV1) DMB2RML MT DTT DMB2RML MA Antagonist DMB2RML RN Transient receptor potential vanilloid type 1 antagonists: a patent review (2011 - 2014).Expert Opin Ther Pat. 2015 Mar;25(3):291-318. DMB2RML RU https://www.ncbi.nlm.nih.gov/pubmed/25666693 DMN0FCA DI DMN0FCA DMN0FCA DN PMID25666693-Compound-108 DMN0FCA MI TTMI6F5 DMN0FCA MN Transient receptor potential cation channel V1 (TRPV1) DMN0FCA MT DTT DMN0FCA MA Antagonist DMN0FCA RN Transient receptor potential vanilloid type 1 antagonists: a patent review (2011 - 2014).Expert Opin Ther Pat. 2015 Mar;25(3):291-318. DMN0FCA RU https://www.ncbi.nlm.nih.gov/pubmed/25666693 DMWGIS7 DI DMWGIS7 DMWGIS7 DN PMID25666693-Compound-109 DMWGIS7 MI TTMI6F5 DMWGIS7 MN Transient receptor potential cation channel V1 (TRPV1) DMWGIS7 MT DTT DMWGIS7 MA Antagonist DMWGIS7 RN Transient receptor potential vanilloid type 1 antagonists: a patent review (2011 - 2014).Expert Opin Ther Pat. 2015 Mar;25(3):291-318. DMWGIS7 RU https://www.ncbi.nlm.nih.gov/pubmed/25666693 DM9HOM6 DI DM9HOM6 DM9HOM6 DN PMID25666693-Compound-11 DM9HOM6 MI TTMI6F5 DM9HOM6 MN Transient receptor potential cation channel V1 (TRPV1) DM9HOM6 MT DTT DM9HOM6 MA Antagonist DM9HOM6 RN Transient receptor potential vanilloid type 1 antagonists: a patent review (2011 - 2014).Expert Opin Ther Pat. 2015 Mar;25(3):291-318. DM9HOM6 RU https://www.ncbi.nlm.nih.gov/pubmed/25666693 DMNGD2S DI DMNGD2S DMNGD2S DN PMID25666693-Compound-110 DMNGD2S MI TTMI6F5 DMNGD2S MN Transient receptor potential cation channel V1 (TRPV1) DMNGD2S MT DTT DMNGD2S MA Antagonist DMNGD2S RN Transient receptor potential vanilloid type 1 antagonists: a patent review (2011 - 2014).Expert Opin Ther Pat. 2015 Mar;25(3):291-318. DMNGD2S RU https://www.ncbi.nlm.nih.gov/pubmed/25666693 DMNKW1E DI DMNKW1E DMNKW1E DN PMID25666693-Compound-111 DMNKW1E MI TTMI6F5 DMNKW1E MN Transient receptor potential cation channel V1 (TRPV1) DMNKW1E MT DTT DMNKW1E MA Antagonist DMNKW1E RN Transient receptor potential vanilloid type 1 antagonists: a patent review (2011 - 2014).Expert Opin Ther Pat. 2015 Mar;25(3):291-318. DMNKW1E RU https://www.ncbi.nlm.nih.gov/pubmed/25666693 DMQOSH5 DI DMQOSH5 DMQOSH5 DN PMID25666693-Compound-112 DMQOSH5 MI TTMI6F5 DMQOSH5 MN Transient receptor potential cation channel V1 (TRPV1) DMQOSH5 MT DTT DMQOSH5 MA Antagonist DMQOSH5 RN Transient receptor potential vanilloid type 1 antagonists: a patent review (2011 - 2014).Expert Opin Ther Pat. 2015 Mar;25(3):291-318. DMQOSH5 RU https://www.ncbi.nlm.nih.gov/pubmed/25666693 DM02O5V DI DM02O5V DM02O5V DN PMID25666693-Compound-113 DM02O5V MI TTMI6F5 DM02O5V MN Transient receptor potential cation channel V1 (TRPV1) DM02O5V MT DTT DM02O5V MA Antagonist DM02O5V RN Transient receptor potential vanilloid type 1 antagonists: a patent review (2011 - 2014).Expert Opin Ther Pat. 2015 Mar;25(3):291-318. DM02O5V RU https://www.ncbi.nlm.nih.gov/pubmed/25666693 DMA9YDK DI DMA9YDK DMA9YDK DN PMID25666693-Compound-114 DMA9YDK MI TTMI6F5 DMA9YDK MN Transient receptor potential cation channel V1 (TRPV1) DMA9YDK MT DTT DMA9YDK MA Antagonist DMA9YDK RN Transient receptor potential vanilloid type 1 antagonists: a patent review (2011 - 2014).Expert Opin Ther Pat. 2015 Mar;25(3):291-318. DMA9YDK RU https://www.ncbi.nlm.nih.gov/pubmed/25666693 DMF5ODZ DI DMF5ODZ DMF5ODZ DN PMID25666693-Compound-115 DMF5ODZ MI TTMI6F5 DMF5ODZ MN Transient receptor potential cation channel V1 (TRPV1) DMF5ODZ MT DTT DMF5ODZ MA Antagonist DMF5ODZ RN Transient receptor potential vanilloid type 1 antagonists: a patent review (2011 - 2014).Expert Opin Ther Pat. 2015 Mar;25(3):291-318. DMF5ODZ RU https://www.ncbi.nlm.nih.gov/pubmed/25666693 DMNEBXL DI DMNEBXL DMNEBXL DN PMID25666693-Compound-116 DMNEBXL MI TTMI6F5 DMNEBXL MN Transient receptor potential cation channel V1 (TRPV1) DMNEBXL MT DTT DMNEBXL MA Antagonist DMNEBXL RN Transient receptor potential vanilloid type 1 antagonists: a patent review (2011 - 2014).Expert Opin Ther Pat. 2015 Mar;25(3):291-318. DMNEBXL RU https://www.ncbi.nlm.nih.gov/pubmed/25666693 DMN9LDH DI DMN9LDH DMN9LDH DN PMID25666693-Compound-117 DMN9LDH MI TTMI6F5 DMN9LDH MN Transient receptor potential cation channel V1 (TRPV1) DMN9LDH MT DTT DMN9LDH MA Antagonist DMN9LDH RN Transient receptor potential vanilloid type 1 antagonists: a patent review (2011 - 2014).Expert Opin Ther Pat. 2015 Mar;25(3):291-318. DMN9LDH RU https://www.ncbi.nlm.nih.gov/pubmed/25666693 DMBIQMS DI DMBIQMS DMBIQMS DN PMID25666693-Compound-118 DMBIQMS MI TTMI6F5 DMBIQMS MN Transient receptor potential cation channel V1 (TRPV1) DMBIQMS MT DTT DMBIQMS MA Antagonist DMBIQMS RN Transient receptor potential vanilloid type 1 antagonists: a patent review (2011 - 2014).Expert Opin Ther Pat. 2015 Mar;25(3):291-318. DMBIQMS RU https://www.ncbi.nlm.nih.gov/pubmed/25666693 DMD0WIA DI DMD0WIA DMD0WIA DN PMID25666693-Compound-119 DMD0WIA MI TTMI6F5 DMD0WIA MN Transient receptor potential cation channel V1 (TRPV1) DMD0WIA MT DTT DMD0WIA MA Antagonist DMD0WIA RN Transient receptor potential vanilloid type 1 antagonists: a patent review (2011 - 2014).Expert Opin Ther Pat. 2015 Mar;25(3):291-318. DMD0WIA RU https://www.ncbi.nlm.nih.gov/pubmed/25666693 DMVSFNE DI DMVSFNE DMVSFNE DN PMID25666693-Compound-12 DMVSFNE MI TTMI6F5 DMVSFNE MN Transient receptor potential cation channel V1 (TRPV1) DMVSFNE MT DTT DMVSFNE MA Antagonist DMVSFNE RN Transient receptor potential vanilloid type 1 antagonists: a patent review (2011 - 2014).Expert Opin Ther Pat. 2015 Mar;25(3):291-318. DMVSFNE RU https://www.ncbi.nlm.nih.gov/pubmed/25666693 DMVREIM DI DMVREIM DMVREIM DN PMID25666693-Compound-120 DMVREIM MI TTMI6F5 DMVREIM MN Transient receptor potential cation channel V1 (TRPV1) DMVREIM MT DTT DMVREIM MA Antagonist DMVREIM RN Transient receptor potential vanilloid type 1 antagonists: a patent review (2011 - 2014).Expert Opin Ther Pat. 2015 Mar;25(3):291-318. DMVREIM RU https://www.ncbi.nlm.nih.gov/pubmed/25666693 DMC1QDB DI DMC1QDB DMC1QDB DN PMID25666693-Compound-121 DMC1QDB MI TTMI6F5 DMC1QDB MN Transient receptor potential cation channel V1 (TRPV1) DMC1QDB MT DTT DMC1QDB MA Antagonist DMC1QDB RN Transient receptor potential vanilloid type 1 antagonists: a patent review (2011 - 2014).Expert Opin Ther Pat. 2015 Mar;25(3):291-318. DMC1QDB RU https://www.ncbi.nlm.nih.gov/pubmed/25666693 DMR63O2 DI DMR63O2 DMR63O2 DN PMID25666693-Compound-122 DMR63O2 MI TTMI6F5 DMR63O2 MN Transient receptor potential cation channel V1 (TRPV1) DMR63O2 MT DTT DMR63O2 MA Antagonist DMR63O2 RN Transient receptor potential vanilloid type 1 antagonists: a patent review (2011 - 2014).Expert Opin Ther Pat. 2015 Mar;25(3):291-318. DMR63O2 RU https://www.ncbi.nlm.nih.gov/pubmed/25666693 DM9358G DI DM9358G DM9358G DN PMID25666693-Compound-123 DM9358G MI TTMI6F5 DM9358G MN Transient receptor potential cation channel V1 (TRPV1) DM9358G MT DTT DM9358G MA Antagonist DM9358G RN Transient receptor potential vanilloid type 1 antagonists: a patent review (2011 - 2014).Expert Opin Ther Pat. 2015 Mar;25(3):291-318. DM9358G RU https://www.ncbi.nlm.nih.gov/pubmed/25666693 DM6ODU7 DI DM6ODU7 DM6ODU7 DN PMID25666693-Compound-124 DM6ODU7 MI TTMI6F5 DM6ODU7 MN Transient receptor potential cation channel V1 (TRPV1) DM6ODU7 MT DTT DM6ODU7 MA Antagonist DM6ODU7 RN Transient receptor potential vanilloid type 1 antagonists: a patent review (2011 - 2014).Expert Opin Ther Pat. 2015 Mar;25(3):291-318. DM6ODU7 RU https://www.ncbi.nlm.nih.gov/pubmed/25666693 DMR0WM1 DI DMR0WM1 DMR0WM1 DN PMID25666693-Compound-125 DMR0WM1 MI TTMI6F5 DMR0WM1 MN Transient receptor potential cation channel V1 (TRPV1) DMR0WM1 MT DTT DMR0WM1 MA Antagonist DMR0WM1 RN Transient receptor potential vanilloid type 1 antagonists: a patent review (2011 - 2014).Expert Opin Ther Pat. 2015 Mar;25(3):291-318. DMR0WM1 RU https://www.ncbi.nlm.nih.gov/pubmed/25666693 DMKN72Y DI DMKN72Y DMKN72Y DN PMID25666693-Compound-126 DMKN72Y MI TTMI6F5 DMKN72Y MN Transient receptor potential cation channel V1 (TRPV1) DMKN72Y MT DTT DMKN72Y MA Antagonist DMKN72Y RN Transient receptor potential vanilloid type 1 antagonists: a patent review (2011 - 2014).Expert Opin Ther Pat. 2015 Mar;25(3):291-318. DMKN72Y RU https://www.ncbi.nlm.nih.gov/pubmed/25666693 DMCE6MB DI DMCE6MB DMCE6MB DN PMID25666693-Compound-127 DMCE6MB MI TTMI6F5 DMCE6MB MN Transient receptor potential cation channel V1 (TRPV1) DMCE6MB MT DTT DMCE6MB MA Antagonist DMCE6MB RN Transient receptor potential vanilloid type 1 antagonists: a patent review (2011 - 2014).Expert Opin Ther Pat. 2015 Mar;25(3):291-318. DMCE6MB RU https://www.ncbi.nlm.nih.gov/pubmed/25666693 DM6QHGV DI DM6QHGV DM6QHGV DN PMID25666693-Compound-128 DM6QHGV MI TTMI6F5 DM6QHGV MN Transient receptor potential cation channel V1 (TRPV1) DM6QHGV MT DTT DM6QHGV MA Antagonist DM6QHGV RN Transient receptor potential vanilloid type 1 antagonists: a patent review (2011 - 2014).Expert Opin Ther Pat. 2015 Mar;25(3):291-318. DM6QHGV RU https://www.ncbi.nlm.nih.gov/pubmed/25666693 DM74NBY DI DM74NBY DM74NBY DN PMID25666693-Compound-129 DM74NBY MI TTMI6F5 DM74NBY MN Transient receptor potential cation channel V1 (TRPV1) DM74NBY MT DTT DM74NBY MA Antagonist DM74NBY RN Transient receptor potential vanilloid type 1 antagonists: a patent review (2011 - 2014).Expert Opin Ther Pat. 2015 Mar;25(3):291-318. DM74NBY RU https://www.ncbi.nlm.nih.gov/pubmed/25666693 DMI0YWU DI DMI0YWU DMI0YWU DN PMID25666693-Compound-13 DMI0YWU MI TTMI6F5 DMI0YWU MN Transient receptor potential cation channel V1 (TRPV1) DMI0YWU MT DTT DMI0YWU MA Antagonist DMI0YWU RN Transient receptor potential vanilloid type 1 antagonists: a patent review (2011 - 2014).Expert Opin Ther Pat. 2015 Mar;25(3):291-318. DMI0YWU RU https://www.ncbi.nlm.nih.gov/pubmed/25666693 DMIX1K0 DI DMIX1K0 DMIX1K0 DN PMID25666693-Compound-130 DMIX1K0 MI TTMI6F5 DMIX1K0 MN Transient receptor potential cation channel V1 (TRPV1) DMIX1K0 MT DTT DMIX1K0 MA Antagonist DMIX1K0 RN Transient receptor potential vanilloid type 1 antagonists: a patent review (2011 - 2014).Expert Opin Ther Pat. 2015 Mar;25(3):291-318. DMIX1K0 RU https://www.ncbi.nlm.nih.gov/pubmed/25666693 DML7SYH DI DML7SYH DML7SYH DN PMID25666693-Compound-131 DML7SYH MI TTMI6F5 DML7SYH MN Transient receptor potential cation channel V1 (TRPV1) DML7SYH MT DTT DML7SYH MA Antagonist DML7SYH RN Transient receptor potential vanilloid type 1 antagonists: a patent review (2011 - 2014).Expert Opin Ther Pat. 2015 Mar;25(3):291-318. DML7SYH RU https://www.ncbi.nlm.nih.gov/pubmed/25666693 DMHQM8W DI DMHQM8W DMHQM8W DN PMID25666693-Compound-132 DMHQM8W MI TTMI6F5 DMHQM8W MN Transient receptor potential cation channel V1 (TRPV1) DMHQM8W MT DTT DMHQM8W MA Antagonist DMHQM8W RN Transient receptor potential vanilloid type 1 antagonists: a patent review (2011 - 2014).Expert Opin Ther Pat. 2015 Mar;25(3):291-318. DMHQM8W RU https://www.ncbi.nlm.nih.gov/pubmed/25666693 DMHEPR3 DI DMHEPR3 DMHEPR3 DN PMID25666693-Compound-133 DMHEPR3 MI TTMI6F5 DMHEPR3 MN Transient receptor potential cation channel V1 (TRPV1) DMHEPR3 MT DTT DMHEPR3 MA Antagonist DMHEPR3 RN Transient receptor potential vanilloid type 1 antagonists: a patent review (2011 - 2014).Expert Opin Ther Pat. 2015 Mar;25(3):291-318. DMHEPR3 RU https://www.ncbi.nlm.nih.gov/pubmed/25666693 DM2WJKR DI DM2WJKR DM2WJKR DN PMID25666693-Compound-134 DM2WJKR MI TTMI6F5 DM2WJKR MN Transient receptor potential cation channel V1 (TRPV1) DM2WJKR MT DTT DM2WJKR MA Antagonist DM2WJKR RN Transient receptor potential vanilloid type 1 antagonists: a patent review (2011 - 2014).Expert Opin Ther Pat. 2015 Mar;25(3):291-318. DM2WJKR RU https://www.ncbi.nlm.nih.gov/pubmed/25666693 DMYZVPD DI DMYZVPD DMYZVPD DN PMID25666693-Compound-135 DMYZVPD MI TTMI6F5 DMYZVPD MN Transient receptor potential cation channel V1 (TRPV1) DMYZVPD MT DTT DMYZVPD MA Antagonist DMYZVPD RN Transient receptor potential vanilloid type 1 antagonists: a patent review (2011 - 2014).Expert Opin Ther Pat. 2015 Mar;25(3):291-318. DMYZVPD RU https://www.ncbi.nlm.nih.gov/pubmed/25666693 DMPY1QC DI DMPY1QC DMPY1QC DN PMID25666693-Compound-136 DMPY1QC MI TTMI6F5 DMPY1QC MN Transient receptor potential cation channel V1 (TRPV1) DMPY1QC MT DTT DMPY1QC MA Antagonist DMPY1QC RN Transient receptor potential vanilloid type 1 antagonists: a patent review (2011 - 2014).Expert Opin Ther Pat. 2015 Mar;25(3):291-318. DMPY1QC RU https://www.ncbi.nlm.nih.gov/pubmed/25666693 DMZ7LAO DI DMZ7LAO DMZ7LAO DN PMID25666693-Compound-137 DMZ7LAO MI TTMI6F5 DMZ7LAO MN Transient receptor potential cation channel V1 (TRPV1) DMZ7LAO MT DTT DMZ7LAO MA Antagonist DMZ7LAO RN Transient receptor potential vanilloid type 1 antagonists: a patent review (2011 - 2014).Expert Opin Ther Pat. 2015 Mar;25(3):291-318. DMZ7LAO RU https://www.ncbi.nlm.nih.gov/pubmed/25666693 DMJLFEN DI DMJLFEN DMJLFEN DN PMID25666693-Compound-138 DMJLFEN MI TTMI6F5 DMJLFEN MN Transient receptor potential cation channel V1 (TRPV1) DMJLFEN MT DTT DMJLFEN MA Antagonist DMJLFEN RN Transient receptor potential vanilloid type 1 antagonists: a patent review (2011 - 2014).Expert Opin Ther Pat. 2015 Mar;25(3):291-318. DMJLFEN RU https://www.ncbi.nlm.nih.gov/pubmed/25666693 DMLMEPI DI DMLMEPI DMLMEPI DN PMID25666693-Compound-139 DMLMEPI MI TTMI6F5 DMLMEPI MN Transient receptor potential cation channel V1 (TRPV1) DMLMEPI MT DTT DMLMEPI MA Antagonist DMLMEPI RN Transient receptor potential vanilloid type 1 antagonists: a patent review (2011 - 2014).Expert Opin Ther Pat. 2015 Mar;25(3):291-318. DMLMEPI RU https://www.ncbi.nlm.nih.gov/pubmed/25666693 DM3D4RI DI DM3D4RI DM3D4RI DN PMID25666693-Compound-14 DM3D4RI MI TTMI6F5 DM3D4RI MN Transient receptor potential cation channel V1 (TRPV1) DM3D4RI MT DTT DM3D4RI MA Antagonist DM3D4RI RN Transient receptor potential vanilloid type 1 antagonists: a patent review (2011 - 2014).Expert Opin Ther Pat. 2015 Mar;25(3):291-318. DM3D4RI RU https://www.ncbi.nlm.nih.gov/pubmed/25666693 DMVQU9T DI DMVQU9T DMVQU9T DN PMID25666693-Compound-140 DMVQU9T MI TTMI6F5 DMVQU9T MN Transient receptor potential cation channel V1 (TRPV1) DMVQU9T MT DTT DMVQU9T MA Antagonist DMVQU9T RN Transient receptor potential vanilloid type 1 antagonists: a patent review (2011 - 2014).Expert Opin Ther Pat. 2015 Mar;25(3):291-318. DMVQU9T RU https://www.ncbi.nlm.nih.gov/pubmed/25666693 DMQGTYE DI DMQGTYE DMQGTYE DN PMID25666693-Compound-141 DMQGTYE MI TTMI6F5 DMQGTYE MN Transient receptor potential cation channel V1 (TRPV1) DMQGTYE MT DTT DMQGTYE MA Antagonist DMQGTYE RN Transient receptor potential vanilloid type 1 antagonists: a patent review (2011 - 2014).Expert Opin Ther Pat. 2015 Mar;25(3):291-318. DMQGTYE RU https://www.ncbi.nlm.nih.gov/pubmed/25666693 DMFKN1O DI DMFKN1O DMFKN1O DN PMID25666693-Compound-142 DMFKN1O MI TTMI6F5 DMFKN1O MN Transient receptor potential cation channel V1 (TRPV1) DMFKN1O MT DTT DMFKN1O MA Antagonist DMFKN1O RN Transient receptor potential vanilloid type 1 antagonists: a patent review (2011 - 2014).Expert Opin Ther Pat. 2015 Mar;25(3):291-318. DMFKN1O RU https://www.ncbi.nlm.nih.gov/pubmed/25666693 DMJP0NB DI DMJP0NB DMJP0NB DN PMID25666693-Compound-143 DMJP0NB MI TTMI6F5 DMJP0NB MN Transient receptor potential cation channel V1 (TRPV1) DMJP0NB MT DTT DMJP0NB MA Antagonist DMJP0NB RN Transient receptor potential vanilloid type 1 antagonists: a patent review (2011 - 2014).Expert Opin Ther Pat. 2015 Mar;25(3):291-318. DMJP0NB RU https://www.ncbi.nlm.nih.gov/pubmed/25666693 DMCXELD DI DMCXELD DMCXELD DN PMID25666693-Compound-144 DMCXELD MI TTMI6F5 DMCXELD MN Transient receptor potential cation channel V1 (TRPV1) DMCXELD MT DTT DMCXELD MA Antagonist DMCXELD RN Transient receptor potential vanilloid type 1 antagonists: a patent review (2011 - 2014).Expert Opin Ther Pat. 2015 Mar;25(3):291-318. DMCXELD RU https://www.ncbi.nlm.nih.gov/pubmed/25666693 DMP89E4 DI DMP89E4 DMP89E4 DN PMID25666693-Compound-145 DMP89E4 MI TTMI6F5 DMP89E4 MN Transient receptor potential cation channel V1 (TRPV1) DMP89E4 MT DTT DMP89E4 MA Antagonist DMP89E4 RN Transient receptor potential vanilloid type 1 antagonists: a patent review (2011 - 2014).Expert Opin Ther Pat. 2015 Mar;25(3):291-318. DMP89E4 RU https://www.ncbi.nlm.nih.gov/pubmed/25666693 DMLE5BK DI DMLE5BK DMLE5BK DN PMID25666693-Compound-146 DMLE5BK MI TTMI6F5 DMLE5BK MN Transient receptor potential cation channel V1 (TRPV1) DMLE5BK MT DTT DMLE5BK MA Antagonist DMLE5BK RN Transient receptor potential vanilloid type 1 antagonists: a patent review (2011 - 2014).Expert Opin Ther Pat. 2015 Mar;25(3):291-318. DMLE5BK RU https://www.ncbi.nlm.nih.gov/pubmed/25666693 DMG1SYN DI DMG1SYN DMG1SYN DN PMID25666693-Compound-147 DMG1SYN MI TTMI6F5 DMG1SYN MN Transient receptor potential cation channel V1 (TRPV1) DMG1SYN MT DTT DMG1SYN MA Antagonist DMG1SYN RN Transient receptor potential vanilloid type 1 antagonists: a patent review (2011 - 2014).Expert Opin Ther Pat. 2015 Mar;25(3):291-318. DMG1SYN RU https://www.ncbi.nlm.nih.gov/pubmed/25666693 DM0EYON DI DM0EYON DM0EYON DN PMID25666693-Compound-148 DM0EYON MI TTMI6F5 DM0EYON MN Transient receptor potential cation channel V1 (TRPV1) DM0EYON MT DTT DM0EYON MA Antagonist DM0EYON RN Transient receptor potential vanilloid type 1 antagonists: a patent review (2011 - 2014).Expert Opin Ther Pat. 2015 Mar;25(3):291-318. DM0EYON RU https://www.ncbi.nlm.nih.gov/pubmed/25666693 DMPU19H DI DMPU19H DMPU19H DN PMID25666693-Compound-149 DMPU19H MI TTMI6F5 DMPU19H MN Transient receptor potential cation channel V1 (TRPV1) DMPU19H MT DTT DMPU19H MA Antagonist DMPU19H RN Transient receptor potential vanilloid type 1 antagonists: a patent review (2011 - 2014).Expert Opin Ther Pat. 2015 Mar;25(3):291-318. DMPU19H RU https://www.ncbi.nlm.nih.gov/pubmed/25666693 DM1G6AE DI DM1G6AE DM1G6AE DN PMID25666693-Compound-15 DM1G6AE MI TTMI6F5 DM1G6AE MN Transient receptor potential cation channel V1 (TRPV1) DM1G6AE MT DTT DM1G6AE MA Antagonist DM1G6AE RN Transient receptor potential vanilloid type 1 antagonists: a patent review (2011 - 2014).Expert Opin Ther Pat. 2015 Mar;25(3):291-318. DM1G6AE RU https://www.ncbi.nlm.nih.gov/pubmed/25666693 DMHMEFY DI DMHMEFY DMHMEFY DN PMID25666693-Compound-150 DMHMEFY MI TTMI6F5 DMHMEFY MN Transient receptor potential cation channel V1 (TRPV1) DMHMEFY MT DTT DMHMEFY MA Antagonist DMHMEFY RN Transient receptor potential vanilloid type 1 antagonists: a patent review (2011 - 2014).Expert Opin Ther Pat. 2015 Mar;25(3):291-318. DMHMEFY RU https://www.ncbi.nlm.nih.gov/pubmed/25666693 DM5CY86 DI DM5CY86 DM5CY86 DN PMID25666693-Compound-151 DM5CY86 MI TTMI6F5 DM5CY86 MN Transient receptor potential cation channel V1 (TRPV1) DM5CY86 MT DTT DM5CY86 MA Antagonist DM5CY86 RN Transient receptor potential vanilloid type 1 antagonists: a patent review (2011 - 2014).Expert Opin Ther Pat. 2015 Mar;25(3):291-318. DM5CY86 RU https://www.ncbi.nlm.nih.gov/pubmed/25666693 DM27154 DI DM27154 DM27154 DN PMID25666693-Compound-152 DM27154 MI TTMI6F5 DM27154 MN Transient receptor potential cation channel V1 (TRPV1) DM27154 MT DTT DM27154 MA Antagonist DM27154 RN Transient receptor potential vanilloid type 1 antagonists: a patent review (2011 - 2014).Expert Opin Ther Pat. 2015 Mar;25(3):291-318. DM27154 RU https://www.ncbi.nlm.nih.gov/pubmed/25666693 DM1FTV6 DI DM1FTV6 DM1FTV6 DN PMID25666693-Compound-153 DM1FTV6 MI TTMI6F5 DM1FTV6 MN Transient receptor potential cation channel V1 (TRPV1) DM1FTV6 MT DTT DM1FTV6 MA Antagonist DM1FTV6 RN Transient receptor potential vanilloid type 1 antagonists: a patent review (2011 - 2014).Expert Opin Ther Pat. 2015 Mar;25(3):291-318. DM1FTV6 RU https://www.ncbi.nlm.nih.gov/pubmed/25666693 DMKNU0Z DI DMKNU0Z DMKNU0Z DN PMID25666693-Compound-154 DMKNU0Z MI TTMI6F5 DMKNU0Z MN Transient receptor potential cation channel V1 (TRPV1) DMKNU0Z MT DTT DMKNU0Z MA Antagonist DMKNU0Z RN Transient receptor potential vanilloid type 1 antagonists: a patent review (2011 - 2014).Expert Opin Ther Pat. 2015 Mar;25(3):291-318. DMKNU0Z RU https://www.ncbi.nlm.nih.gov/pubmed/25666693 DMZLB07 DI DMZLB07 DMZLB07 DN PMID25666693-Compound-155 DMZLB07 MI TTMI6F5 DMZLB07 MN Transient receptor potential cation channel V1 (TRPV1) DMZLB07 MT DTT DMZLB07 MA Antagonist DMZLB07 RN Transient receptor potential vanilloid type 1 antagonists: a patent review (2011 - 2014).Expert Opin Ther Pat. 2015 Mar;25(3):291-318. DMZLB07 RU https://www.ncbi.nlm.nih.gov/pubmed/25666693 DMTVAUP DI DMTVAUP DMTVAUP DN PMID25666693-Compound-156 DMTVAUP MI TTMI6F5 DMTVAUP MN Transient receptor potential cation channel V1 (TRPV1) DMTVAUP MT DTT DMTVAUP MA Antagonist DMTVAUP RN Transient receptor potential vanilloid type 1 antagonists: a patent review (2011 - 2014).Expert Opin Ther Pat. 2015 Mar;25(3):291-318. DMTVAUP RU https://www.ncbi.nlm.nih.gov/pubmed/25666693 DME8LUY DI DME8LUY DME8LUY DN PMID25666693-Compound-157 DME8LUY MI TTMI6F5 DME8LUY MN Transient receptor potential cation channel V1 (TRPV1) DME8LUY MT DTT DME8LUY MA Antagonist DME8LUY RN Transient receptor potential vanilloid type 1 antagonists: a patent review (2011 - 2014).Expert Opin Ther Pat. 2015 Mar;25(3):291-318. DME8LUY RU https://www.ncbi.nlm.nih.gov/pubmed/25666693 DM2BTCU DI DM2BTCU DM2BTCU DN PMID25666693-Compound-158 DM2BTCU MI TTMI6F5 DM2BTCU MN Transient receptor potential cation channel V1 (TRPV1) DM2BTCU MT DTT DM2BTCU MA Antagonist DM2BTCU RN Transient receptor potential vanilloid type 1 antagonists: a patent review (2011 - 2014).Expert Opin Ther Pat. 2015 Mar;25(3):291-318. DM2BTCU RU https://www.ncbi.nlm.nih.gov/pubmed/25666693 DM74OGS DI DM74OGS DM74OGS DN PMID25666693-Compound-159 DM74OGS MI TTMI6F5 DM74OGS MN Transient receptor potential cation channel V1 (TRPV1) DM74OGS MT DTT DM74OGS MA Antagonist DM74OGS RN Transient receptor potential vanilloid type 1 antagonists: a patent review (2011 - 2014).Expert Opin Ther Pat. 2015 Mar;25(3):291-318. DM74OGS RU https://www.ncbi.nlm.nih.gov/pubmed/25666693 DM6SL9D DI DM6SL9D DM6SL9D DN PMID25666693-Compound-16 DM6SL9D MI TTMI6F5 DM6SL9D MN Transient receptor potential cation channel V1 (TRPV1) DM6SL9D MT DTT DM6SL9D MA Antagonist DM6SL9D RN Transient receptor potential vanilloid type 1 antagonists: a patent review (2011 - 2014).Expert Opin Ther Pat. 2015 Mar;25(3):291-318. DM6SL9D RU https://www.ncbi.nlm.nih.gov/pubmed/25666693 DM2KTAB DI DM2KTAB DM2KTAB DN PMID25666693-Compound-160 DM2KTAB MI TTMI6F5 DM2KTAB MN Transient receptor potential cation channel V1 (TRPV1) DM2KTAB MT DTT DM2KTAB MA Antagonist DM2KTAB RN Transient receptor potential vanilloid type 1 antagonists: a patent review (2011 - 2014).Expert Opin Ther Pat. 2015 Mar;25(3):291-318. DM2KTAB RU https://www.ncbi.nlm.nih.gov/pubmed/25666693 DM06IWA DI DM06IWA DM06IWA DN PMID25666693-Compound-161 DM06IWA MI TTMI6F5 DM06IWA MN Transient receptor potential cation channel V1 (TRPV1) DM06IWA MT DTT DM06IWA MA Antagonist DM06IWA RN Transient receptor potential vanilloid type 1 antagonists: a patent review (2011 - 2014).Expert Opin Ther Pat. 2015 Mar;25(3):291-318. DM06IWA RU https://www.ncbi.nlm.nih.gov/pubmed/25666693 DMXS5WY DI DMXS5WY DMXS5WY DN PMID25666693-Compound-162 DMXS5WY MI TTMI6F5 DMXS5WY MN Transient receptor potential cation channel V1 (TRPV1) DMXS5WY MT DTT DMXS5WY MA Antagonist DMXS5WY RN Transient receptor potential vanilloid type 1 antagonists: a patent review (2011 - 2014).Expert Opin Ther Pat. 2015 Mar;25(3):291-318. DMXS5WY RU https://www.ncbi.nlm.nih.gov/pubmed/25666693 DMRK1W7 DI DMRK1W7 DMRK1W7 DN PMID25666693-Compound-17 DMRK1W7 MI TTMI6F5 DMRK1W7 MN Transient receptor potential cation channel V1 (TRPV1) DMRK1W7 MT DTT DMRK1W7 MA Antagonist DMRK1W7 RN Transient receptor potential vanilloid type 1 antagonists: a patent review (2011 - 2014).Expert Opin Ther Pat. 2015 Mar;25(3):291-318. DMRK1W7 RU https://www.ncbi.nlm.nih.gov/pubmed/25666693 DMKU6C3 DI DMKU6C3 DMKU6C3 DN PMID25666693-Compound-18 DMKU6C3 MI TTMI6F5 DMKU6C3 MN Transient receptor potential cation channel V1 (TRPV1) DMKU6C3 MT DTT DMKU6C3 MA Antagonist DMKU6C3 RN Transient receptor potential vanilloid type 1 antagonists: a patent review (2011 - 2014).Expert Opin Ther Pat. 2015 Mar;25(3):291-318. DMKU6C3 RU https://www.ncbi.nlm.nih.gov/pubmed/25666693 DM63UM8 DI DM63UM8 DM63UM8 DN PMID25666693-Compound-19 DM63UM8 MI TTMI6F5 DM63UM8 MN Transient receptor potential cation channel V1 (TRPV1) DM63UM8 MT DTT DM63UM8 MA Antagonist DM63UM8 RN Transient receptor potential vanilloid type 1 antagonists: a patent review (2011 - 2014).Expert Opin Ther Pat. 2015 Mar;25(3):291-318. DM63UM8 RU https://www.ncbi.nlm.nih.gov/pubmed/25666693 DMERD39 DI DMERD39 DMERD39 DN PMID25666693-Compound-2 DMERD39 MI TTMI6F5 DMERD39 MN Transient receptor potential cation channel V1 (TRPV1) DMERD39 MT DTT DMERD39 MA Antagonist DMERD39 RN Transient receptor potential vanilloid type 1 antagonists: a patent review (2011 - 2014).Expert Opin Ther Pat. 2015 Mar;25(3):291-318. DMERD39 RU https://www.ncbi.nlm.nih.gov/pubmed/25666693 DM3I90D DI DM3I90D DM3I90D DN PMID25666693-Compound-20 DM3I90D MI TTMI6F5 DM3I90D MN Transient receptor potential cation channel V1 (TRPV1) DM3I90D MT DTT DM3I90D MA Antagonist DM3I90D RN Transient receptor potential vanilloid type 1 antagonists: a patent review (2011 - 2014).Expert Opin Ther Pat. 2015 Mar;25(3):291-318. DM3I90D RU https://www.ncbi.nlm.nih.gov/pubmed/25666693 DMUXO47 DI DMUXO47 DMUXO47 DN PMID25666693-Compound-21 DMUXO47 MI TTMI6F5 DMUXO47 MN Transient receptor potential cation channel V1 (TRPV1) DMUXO47 MT DTT DMUXO47 MA Antagonist DMUXO47 RN Transient receptor potential vanilloid type 1 antagonists: a patent review (2011 - 2014).Expert Opin Ther Pat. 2015 Mar;25(3):291-318. DMUXO47 RU https://www.ncbi.nlm.nih.gov/pubmed/25666693 DMHPW3X DI DMHPW3X DMHPW3X DN PMID25666693-Compound-22 DMHPW3X MI TTMI6F5 DMHPW3X MN Transient receptor potential cation channel V1 (TRPV1) DMHPW3X MT DTT DMHPW3X MA Antagonist DMHPW3X RN Transient receptor potential vanilloid type 1 antagonists: a patent review (2011 - 2014).Expert Opin Ther Pat. 2015 Mar;25(3):291-318. DMHPW3X RU https://www.ncbi.nlm.nih.gov/pubmed/25666693 DMJ3YDT DI DMJ3YDT DMJ3YDT DN PMID25666693-Compound-23 DMJ3YDT MI TTMI6F5 DMJ3YDT MN Transient receptor potential cation channel V1 (TRPV1) DMJ3YDT MT DTT DMJ3YDT MA Antagonist DMJ3YDT RN Transient receptor potential vanilloid type 1 antagonists: a patent review (2011 - 2014).Expert Opin Ther Pat. 2015 Mar;25(3):291-318. DMJ3YDT RU https://www.ncbi.nlm.nih.gov/pubmed/25666693 DMUMYKX DI DMUMYKX DMUMYKX DN PMID25666693-Compound-24 DMUMYKX MI TTMI6F5 DMUMYKX MN Transient receptor potential cation channel V1 (TRPV1) DMUMYKX MT DTT DMUMYKX MA Antagonist DMUMYKX RN Transient receptor potential vanilloid type 1 antagonists: a patent review (2011 - 2014).Expert Opin Ther Pat. 2015 Mar;25(3):291-318. DMUMYKX RU https://www.ncbi.nlm.nih.gov/pubmed/25666693 DMI8CB3 DI DMI8CB3 DMI8CB3 DN PMID25666693-Compound-25 DMI8CB3 MI TTMI6F5 DMI8CB3 MN Transient receptor potential cation channel V1 (TRPV1) DMI8CB3 MT DTT DMI8CB3 MA Antagonist DMI8CB3 RN Transient receptor potential vanilloid type 1 antagonists: a patent review (2011 - 2014).Expert Opin Ther Pat. 2015 Mar;25(3):291-318. DMI8CB3 RU https://www.ncbi.nlm.nih.gov/pubmed/25666693 DMQBFI2 DI DMQBFI2 DMQBFI2 DN PMID25666693-Compound-26 DMQBFI2 MI TTMI6F5 DMQBFI2 MN Transient receptor potential cation channel V1 (TRPV1) DMQBFI2 MT DTT DMQBFI2 MA Antagonist DMQBFI2 RN Transient receptor potential vanilloid type 1 antagonists: a patent review (2011 - 2014).Expert Opin Ther Pat. 2015 Mar;25(3):291-318. DMQBFI2 RU https://www.ncbi.nlm.nih.gov/pubmed/25666693 DMKHO8T DI DMKHO8T DMKHO8T DN PMID25666693-Compound-27 DMKHO8T MI TTMI6F5 DMKHO8T MN Transient receptor potential cation channel V1 (TRPV1) DMKHO8T MT DTT DMKHO8T MA Antagonist DMKHO8T RN Transient receptor potential vanilloid type 1 antagonists: a patent review (2011 - 2014).Expert Opin Ther Pat. 2015 Mar;25(3):291-318. DMKHO8T RU https://www.ncbi.nlm.nih.gov/pubmed/25666693 DM7T962 DI DM7T962 DM7T962 DN PMID25666693-Compound-28 DM7T962 MI TTMI6F5 DM7T962 MN Transient receptor potential cation channel V1 (TRPV1) DM7T962 MT DTT DM7T962 MA Antagonist DM7T962 RN Transient receptor potential vanilloid type 1 antagonists: a patent review (2011 - 2014).Expert Opin Ther Pat. 2015 Mar;25(3):291-318. DM7T962 RU https://www.ncbi.nlm.nih.gov/pubmed/25666693 DM02D1B DI DM02D1B DM02D1B DN PMID25666693-Compound-29 DM02D1B MI TTMI6F5 DM02D1B MN Transient receptor potential cation channel V1 (TRPV1) DM02D1B MT DTT DM02D1B MA Antagonist DM02D1B RN Transient receptor potential vanilloid type 1 antagonists: a patent review (2011 - 2014).Expert Opin Ther Pat. 2015 Mar;25(3):291-318. DM02D1B RU https://www.ncbi.nlm.nih.gov/pubmed/25666693 DMN692C DI DMN692C DMN692C DN PMID25666693-Compound-3 DMN692C MI TTMI6F5 DMN692C MN Transient receptor potential cation channel V1 (TRPV1) DMN692C MT DTT DMN692C MA Antagonist DMN692C RN Transient receptor potential vanilloid type 1 antagonists: a patent review (2011 - 2014).Expert Opin Ther Pat. 2015 Mar;25(3):291-318. DMN692C RU https://www.ncbi.nlm.nih.gov/pubmed/25666693 DMC3DT7 DI DMC3DT7 DMC3DT7 DN PMID25666693-Compound-30 DMC3DT7 MI TTMI6F5 DMC3DT7 MN Transient receptor potential cation channel V1 (TRPV1) DMC3DT7 MT DTT DMC3DT7 MA Antagonist DMC3DT7 RN Transient receptor potential vanilloid type 1 antagonists: a patent review (2011 - 2014).Expert Opin Ther Pat. 2015 Mar;25(3):291-318. DMC3DT7 RU https://www.ncbi.nlm.nih.gov/pubmed/25666693 DM853Y7 DI DM853Y7 DM853Y7 DN PMID25666693-Compound-31 DM853Y7 MI TTMI6F5 DM853Y7 MN Transient receptor potential cation channel V1 (TRPV1) DM853Y7 MT DTT DM853Y7 MA Antagonist DM853Y7 RN Transient receptor potential vanilloid type 1 antagonists: a patent review (2011 - 2014).Expert Opin Ther Pat. 2015 Mar;25(3):291-318. DM853Y7 RU https://www.ncbi.nlm.nih.gov/pubmed/25666693 DM58Z4M DI DM58Z4M DM58Z4M DN PMID25666693-Compound-32 DM58Z4M MI TTMI6F5 DM58Z4M MN Transient receptor potential cation channel V1 (TRPV1) DM58Z4M MT DTT DM58Z4M MA Antagonist DM58Z4M RN Transient receptor potential vanilloid type 1 antagonists: a patent review (2011 - 2014).Expert Opin Ther Pat. 2015 Mar;25(3):291-318. DM58Z4M RU https://www.ncbi.nlm.nih.gov/pubmed/25666693 DMW7981 DI DMW7981 DMW7981 DN PMID25666693-Compound-33 DMW7981 MI TTMI6F5 DMW7981 MN Transient receptor potential cation channel V1 (TRPV1) DMW7981 MT DTT DMW7981 MA Antagonist DMW7981 RN Transient receptor potential vanilloid type 1 antagonists: a patent review (2011 - 2014).Expert Opin Ther Pat. 2015 Mar;25(3):291-318. DMW7981 RU https://www.ncbi.nlm.nih.gov/pubmed/25666693 DMWGAQU DI DMWGAQU DMWGAQU DN PMID25666693-Compound-34 DMWGAQU MI TTMI6F5 DMWGAQU MN Transient receptor potential cation channel V1 (TRPV1) DMWGAQU MT DTT DMWGAQU MA Antagonist DMWGAQU RN Transient receptor potential vanilloid type 1 antagonists: a patent review (2011 - 2014).Expert Opin Ther Pat. 2015 Mar;25(3):291-318. DMWGAQU RU https://www.ncbi.nlm.nih.gov/pubmed/25666693 DMG9CPH DI DMG9CPH DMG9CPH DN PMID25666693-Compound-35 DMG9CPH MI TTMI6F5 DMG9CPH MN Transient receptor potential cation channel V1 (TRPV1) DMG9CPH MT DTT DMG9CPH MA Antagonist DMG9CPH RN Transient receptor potential vanilloid type 1 antagonists: a patent review (2011 - 2014).Expert Opin Ther Pat. 2015 Mar;25(3):291-318. DMG9CPH RU https://www.ncbi.nlm.nih.gov/pubmed/25666693 DMWVR81 DI DMWVR81 DMWVR81 DN PMID25666693-Compound-36 DMWVR81 MI TTMI6F5 DMWVR81 MN Transient receptor potential cation channel V1 (TRPV1) DMWVR81 MT DTT DMWVR81 MA Antagonist DMWVR81 RN Transient receptor potential vanilloid type 1 antagonists: a patent review (2011 - 2014).Expert Opin Ther Pat. 2015 Mar;25(3):291-318. DMWVR81 RU https://www.ncbi.nlm.nih.gov/pubmed/25666693 DMSR218 DI DMSR218 DMSR218 DN PMID25666693-Compound-37 DMSR218 MI TTMI6F5 DMSR218 MN Transient receptor potential cation channel V1 (TRPV1) DMSR218 MT DTT DMSR218 MA Antagonist DMSR218 RN Transient receptor potential vanilloid type 1 antagonists: a patent review (2011 - 2014).Expert Opin Ther Pat. 2015 Mar;25(3):291-318. DMSR218 RU https://www.ncbi.nlm.nih.gov/pubmed/25666693 DMBW36Y DI DMBW36Y DMBW36Y DN PMID25666693-Compound-38 DMBW36Y MI TTMI6F5 DMBW36Y MN Transient receptor potential cation channel V1 (TRPV1) DMBW36Y MT DTT DMBW36Y MA Antagonist DMBW36Y RN Transient receptor potential vanilloid type 1 antagonists: a patent review (2011 - 2014).Expert Opin Ther Pat. 2015 Mar;25(3):291-318. DMBW36Y RU https://www.ncbi.nlm.nih.gov/pubmed/25666693 DML3KHF DI DML3KHF DML3KHF DN PMID25666693-Compound-39 DML3KHF MI TTMI6F5 DML3KHF MN Transient receptor potential cation channel V1 (TRPV1) DML3KHF MT DTT DML3KHF MA Antagonist DML3KHF RN Transient receptor potential vanilloid type 1 antagonists: a patent review (2011 - 2014).Expert Opin Ther Pat. 2015 Mar;25(3):291-318. DML3KHF RU https://www.ncbi.nlm.nih.gov/pubmed/25666693 DMBD9S5 DI DMBD9S5 DMBD9S5 DN PMID25666693-Compound-4 DMBD9S5 MI TTMI6F5 DMBD9S5 MN Transient receptor potential cation channel V1 (TRPV1) DMBD9S5 MT DTT DMBD9S5 MA Antagonist DMBD9S5 RN Transient receptor potential vanilloid type 1 antagonists: a patent review (2011 - 2014).Expert Opin Ther Pat. 2015 Mar;25(3):291-318. DMBD9S5 RU https://www.ncbi.nlm.nih.gov/pubmed/25666693 DM58QW1 DI DM58QW1 DM58QW1 DN PMID25666693-Compound-40 DM58QW1 MI TTMI6F5 DM58QW1 MN Transient receptor potential cation channel V1 (TRPV1) DM58QW1 MT DTT DM58QW1 MA Antagonist DM58QW1 RN Transient receptor potential vanilloid type 1 antagonists: a patent review (2011 - 2014).Expert Opin Ther Pat. 2015 Mar;25(3):291-318. DM58QW1 RU https://www.ncbi.nlm.nih.gov/pubmed/25666693 DML76MF DI DML76MF DML76MF DN PMID25666693-Compound-41 DML76MF MI TTMI6F5 DML76MF MN Transient receptor potential cation channel V1 (TRPV1) DML76MF MT DTT DML76MF MA Antagonist DML76MF RN Transient receptor potential vanilloid type 1 antagonists: a patent review (2011 - 2014).Expert Opin Ther Pat. 2015 Mar;25(3):291-318. DML76MF RU https://www.ncbi.nlm.nih.gov/pubmed/25666693 DM6I49E DI DM6I49E DM6I49E DN PMID25666693-Compound-42 DM6I49E MI TTMI6F5 DM6I49E MN Transient receptor potential cation channel V1 (TRPV1) DM6I49E MT DTT DM6I49E MA Antagonist DM6I49E RN Transient receptor potential vanilloid type 1 antagonists: a patent review (2011 - 2014).Expert Opin Ther Pat. 2015 Mar;25(3):291-318. DM6I49E RU https://www.ncbi.nlm.nih.gov/pubmed/25666693 DMTN25V DI DMTN25V DMTN25V DN PMID25666693-Compound-43 DMTN25V MI TTMI6F5 DMTN25V MN Transient receptor potential cation channel V1 (TRPV1) DMTN25V MT DTT DMTN25V MA Antagonist DMTN25V RN Transient receptor potential vanilloid type 1 antagonists: a patent review (2011 - 2014).Expert Opin Ther Pat. 2015 Mar;25(3):291-318. DMTN25V RU https://www.ncbi.nlm.nih.gov/pubmed/25666693 DM0I72B DI DM0I72B DM0I72B DN PMID25666693-Compound-44 DM0I72B MI TTMI6F5 DM0I72B MN Transient receptor potential cation channel V1 (TRPV1) DM0I72B MT DTT DM0I72B MA Antagonist DM0I72B RN Transient receptor potential vanilloid type 1 antagonists: a patent review (2011 - 2014).Expert Opin Ther Pat. 2015 Mar;25(3):291-318. DM0I72B RU https://www.ncbi.nlm.nih.gov/pubmed/25666693 DMVDKXY DI DMVDKXY DMVDKXY DN PMID25666693-Compound-45 DMVDKXY MI TTMI6F5 DMVDKXY MN Transient receptor potential cation channel V1 (TRPV1) DMVDKXY MT DTT DMVDKXY MA Antagonist DMVDKXY RN Transient receptor potential vanilloid type 1 antagonists: a patent review (2011 - 2014).Expert Opin Ther Pat. 2015 Mar;25(3):291-318. DMVDKXY RU https://www.ncbi.nlm.nih.gov/pubmed/25666693 DM0MEXT DI DM0MEXT DM0MEXT DN PMID25666693-Compound-46 DM0MEXT MI TTMI6F5 DM0MEXT MN Transient receptor potential cation channel V1 (TRPV1) DM0MEXT MT DTT DM0MEXT MA Antagonist DM0MEXT RN Transient receptor potential vanilloid type 1 antagonists: a patent review (2011 - 2014).Expert Opin Ther Pat. 2015 Mar;25(3):291-318. DM0MEXT RU https://www.ncbi.nlm.nih.gov/pubmed/25666693 DMHBN5M DI DMHBN5M DMHBN5M DN PMID25666693-Compound-47 DMHBN5M MI TTMI6F5 DMHBN5M MN Transient receptor potential cation channel V1 (TRPV1) DMHBN5M MT DTT DMHBN5M MA Antagonist DMHBN5M RN Transient receptor potential vanilloid type 1 antagonists: a patent review (2011 - 2014).Expert Opin Ther Pat. 2015 Mar;25(3):291-318. DMHBN5M RU https://www.ncbi.nlm.nih.gov/pubmed/25666693 DMEVL0S DI DMEVL0S DMEVL0S DN PMID25666693-Compound-48 DMEVL0S MI TTMI6F5 DMEVL0S MN Transient receptor potential cation channel V1 (TRPV1) DMEVL0S MT DTT DMEVL0S MA Antagonist DMEVL0S RN Transient receptor potential vanilloid type 1 antagonists: a patent review (2011 - 2014).Expert Opin Ther Pat. 2015 Mar;25(3):291-318. DMEVL0S RU https://www.ncbi.nlm.nih.gov/pubmed/25666693 DM67DEG DI DM67DEG DM67DEG DN PMID25666693-Compound-49 DM67DEG MI TTMI6F5 DM67DEG MN Transient receptor potential cation channel V1 (TRPV1) DM67DEG MT DTT DM67DEG MA Antagonist DM67DEG RN Transient receptor potential vanilloid type 1 antagonists: a patent review (2011 - 2014).Expert Opin Ther Pat. 2015 Mar;25(3):291-318. DM67DEG RU https://www.ncbi.nlm.nih.gov/pubmed/25666693 DM53PBG DI DM53PBG DM53PBG DN PMID25666693-Compound-5 DM53PBG MI TTMI6F5 DM53PBG MN Transient receptor potential cation channel V1 (TRPV1) DM53PBG MT DTT DM53PBG MA Antagonist DM53PBG RN Transient receptor potential vanilloid type 1 antagonists: a patent review (2011 - 2014).Expert Opin Ther Pat. 2015 Mar;25(3):291-318. DM53PBG RU https://www.ncbi.nlm.nih.gov/pubmed/25666693 DM4GUZO DI DM4GUZO DM4GUZO DN PMID25666693-Compound-50 DM4GUZO MI TTMI6F5 DM4GUZO MN Transient receptor potential cation channel V1 (TRPV1) DM4GUZO MT DTT DM4GUZO MA Antagonist DM4GUZO RN Transient receptor potential vanilloid type 1 antagonists: a patent review (2011 - 2014).Expert Opin Ther Pat. 2015 Mar;25(3):291-318. DM4GUZO RU https://www.ncbi.nlm.nih.gov/pubmed/25666693 DM3KSV9 DI DM3KSV9 DM3KSV9 DN PMID25666693-Compound-51 DM3KSV9 MI TTMI6F5 DM3KSV9 MN Transient receptor potential cation channel V1 (TRPV1) DM3KSV9 MT DTT DM3KSV9 MA Antagonist DM3KSV9 RN Transient receptor potential vanilloid type 1 antagonists: a patent review (2011 - 2014).Expert Opin Ther Pat. 2015 Mar;25(3):291-318. DM3KSV9 RU https://www.ncbi.nlm.nih.gov/pubmed/25666693 DMQPOGC DI DMQPOGC DMQPOGC DN PMID25666693-Compound-52 DMQPOGC MI TTMI6F5 DMQPOGC MN Transient receptor potential cation channel V1 (TRPV1) DMQPOGC MT DTT DMQPOGC MA Antagonist DMQPOGC RN Transient receptor potential vanilloid type 1 antagonists: a patent review (2011 - 2014).Expert Opin Ther Pat. 2015 Mar;25(3):291-318. DMQPOGC RU https://www.ncbi.nlm.nih.gov/pubmed/25666693 DMKCARH DI DMKCARH DMKCARH DN PMID25666693-Compound-53 DMKCARH MI TTMI6F5 DMKCARH MN Transient receptor potential cation channel V1 (TRPV1) DMKCARH MT DTT DMKCARH MA Antagonist DMKCARH RN Transient receptor potential vanilloid type 1 antagonists: a patent review (2011 - 2014).Expert Opin Ther Pat. 2015 Mar;25(3):291-318. DMKCARH RU https://www.ncbi.nlm.nih.gov/pubmed/25666693 DMLW95Y DI DMLW95Y DMLW95Y DN PMID25666693-Compound-54 DMLW95Y MI TTMI6F5 DMLW95Y MN Transient receptor potential cation channel V1 (TRPV1) DMLW95Y MT DTT DMLW95Y MA Antagonist DMLW95Y RN Transient receptor potential vanilloid type 1 antagonists: a patent review (2011 - 2014).Expert Opin Ther Pat. 2015 Mar;25(3):291-318. DMLW95Y RU https://www.ncbi.nlm.nih.gov/pubmed/25666693 DMPE7M8 DI DMPE7M8 DMPE7M8 DN PMID25666693-Compound-55 DMPE7M8 MI TTMI6F5 DMPE7M8 MN Transient receptor potential cation channel V1 (TRPV1) DMPE7M8 MT DTT DMPE7M8 MA Antagonist DMPE7M8 RN Transient receptor potential vanilloid type 1 antagonists: a patent review (2011 - 2014).Expert Opin Ther Pat. 2015 Mar;25(3):291-318. DMPE7M8 RU https://www.ncbi.nlm.nih.gov/pubmed/25666693 DM82BAM DI DM82BAM DM82BAM DN PMID25666693-Compound-56 DM82BAM MI TTMI6F5 DM82BAM MN Transient receptor potential cation channel V1 (TRPV1) DM82BAM MT DTT DM82BAM MA Antagonist DM82BAM RN Transient receptor potential vanilloid type 1 antagonists: a patent review (2011 - 2014).Expert Opin Ther Pat. 2015 Mar;25(3):291-318. DM82BAM RU https://www.ncbi.nlm.nih.gov/pubmed/25666693 DMQRFXT DI DMQRFXT DMQRFXT DN PMID25666693-Compound-57 DMQRFXT MI TTMI6F5 DMQRFXT MN Transient receptor potential cation channel V1 (TRPV1) DMQRFXT MT DTT DMQRFXT MA Antagonist DMQRFXT RN Transient receptor potential vanilloid type 1 antagonists: a patent review (2011 - 2014).Expert Opin Ther Pat. 2015 Mar;25(3):291-318. DMQRFXT RU https://www.ncbi.nlm.nih.gov/pubmed/25666693 DMJEH0F DI DMJEH0F DMJEH0F DN PMID25666693-Compound-58 DMJEH0F MI TTMI6F5 DMJEH0F MN Transient receptor potential cation channel V1 (TRPV1) DMJEH0F MT DTT DMJEH0F MA Antagonist DMJEH0F RN Transient receptor potential vanilloid type 1 antagonists: a patent review (2011 - 2014).Expert Opin Ther Pat. 2015 Mar;25(3):291-318. DMJEH0F RU https://www.ncbi.nlm.nih.gov/pubmed/25666693 DMLI1YR DI DMLI1YR DMLI1YR DN PMID25666693-Compound-59 DMLI1YR MI TTMI6F5 DMLI1YR MN Transient receptor potential cation channel V1 (TRPV1) DMLI1YR MT DTT DMLI1YR MA Antagonist DMLI1YR RN Transient receptor potential vanilloid type 1 antagonists: a patent review (2011 - 2014).Expert Opin Ther Pat. 2015 Mar;25(3):291-318. DMLI1YR RU https://www.ncbi.nlm.nih.gov/pubmed/25666693 DMC5W1Y DI DMC5W1Y DMC5W1Y DN PMID25666693-Compound-6 DMC5W1Y MI TTMI6F5 DMC5W1Y MN Transient receptor potential cation channel V1 (TRPV1) DMC5W1Y MT DTT DMC5W1Y MA Antagonist DMC5W1Y RN Transient receptor potential vanilloid type 1 antagonists: a patent review (2011 - 2014).Expert Opin Ther Pat. 2015 Mar;25(3):291-318. DMC5W1Y RU https://www.ncbi.nlm.nih.gov/pubmed/25666693 DM2C58A DI DM2C58A DM2C58A DN PMID25666693-Compound-60 DM2C58A MI TTMI6F5 DM2C58A MN Transient receptor potential cation channel V1 (TRPV1) DM2C58A MT DTT DM2C58A MA Antagonist DM2C58A RN Transient receptor potential vanilloid type 1 antagonists: a patent review (2011 - 2014).Expert Opin Ther Pat. 2015 Mar;25(3):291-318. DM2C58A RU https://www.ncbi.nlm.nih.gov/pubmed/25666693 DM0B578 DI DM0B578 DM0B578 DN PMID25666693-Compound-61 DM0B578 MI TTMI6F5 DM0B578 MN Transient receptor potential cation channel V1 (TRPV1) DM0B578 MT DTT DM0B578 MA Antagonist DM0B578 RN Transient receptor potential vanilloid type 1 antagonists: a patent review (2011 - 2014).Expert Opin Ther Pat. 2015 Mar;25(3):291-318. DM0B578 RU https://www.ncbi.nlm.nih.gov/pubmed/25666693 DMDMFJG DI DMDMFJG DMDMFJG DN PMID25666693-Compound-62 DMDMFJG MI TTMI6F5 DMDMFJG MN Transient receptor potential cation channel V1 (TRPV1) DMDMFJG MT DTT DMDMFJG MA Antagonist DMDMFJG RN Transient receptor potential vanilloid type 1 antagonists: a patent review (2011 - 2014).Expert Opin Ther Pat. 2015 Mar;25(3):291-318. DMDMFJG RU https://www.ncbi.nlm.nih.gov/pubmed/25666693 DM6DFAK DI DM6DFAK DM6DFAK DN PMID25666693-Compound-63 DM6DFAK MI TTMI6F5 DM6DFAK MN Transient receptor potential cation channel V1 (TRPV1) DM6DFAK MT DTT DM6DFAK MA Antagonist DM6DFAK RN Transient receptor potential vanilloid type 1 antagonists: a patent review (2011 - 2014).Expert Opin Ther Pat. 2015 Mar;25(3):291-318. DM6DFAK RU https://www.ncbi.nlm.nih.gov/pubmed/25666693 DMDWH8T DI DMDWH8T DMDWH8T DN PMID25666693-Compound-64 DMDWH8T MI TTMI6F5 DMDWH8T MN Transient receptor potential cation channel V1 (TRPV1) DMDWH8T MT DTT DMDWH8T MA Antagonist DMDWH8T RN Transient receptor potential vanilloid type 1 antagonists: a patent review (2011 - 2014).Expert Opin Ther Pat. 2015 Mar;25(3):291-318. DMDWH8T RU https://www.ncbi.nlm.nih.gov/pubmed/25666693 DM1A0GT DI DM1A0GT DM1A0GT DN PMID25666693-Compound-65 DM1A0GT MI TTMI6F5 DM1A0GT MN Transient receptor potential cation channel V1 (TRPV1) DM1A0GT MT DTT DM1A0GT MA Antagonist DM1A0GT RN Transient receptor potential vanilloid type 1 antagonists: a patent review (2011 - 2014).Expert Opin Ther Pat. 2015 Mar;25(3):291-318. DM1A0GT RU https://www.ncbi.nlm.nih.gov/pubmed/25666693 DMD13OS DI DMD13OS DMD13OS DN PMID25666693-Compound-66 DMD13OS MI TTMI6F5 DMD13OS MN Transient receptor potential cation channel V1 (TRPV1) DMD13OS MT DTT DMD13OS MA Antagonist DMD13OS RN Transient receptor potential vanilloid type 1 antagonists: a patent review (2011 - 2014).Expert Opin Ther Pat. 2015 Mar;25(3):291-318. DMD13OS RU https://www.ncbi.nlm.nih.gov/pubmed/25666693 DMPV9L2 DI DMPV9L2 DMPV9L2 DN PMID25666693-Compound-67 DMPV9L2 MI TTMI6F5 DMPV9L2 MN Transient receptor potential cation channel V1 (TRPV1) DMPV9L2 MT DTT DMPV9L2 MA Antagonist DMPV9L2 RN Transient receptor potential vanilloid type 1 antagonists: a patent review (2011 - 2014).Expert Opin Ther Pat. 2015 Mar;25(3):291-318. DMPV9L2 RU https://www.ncbi.nlm.nih.gov/pubmed/25666693 DM87HTO DI DM87HTO DM87HTO DN PMID25666693-Compound-68 DM87HTO MI TTMI6F5 DM87HTO MN Transient receptor potential cation channel V1 (TRPV1) DM87HTO MT DTT DM87HTO MA Antagonist DM87HTO RN Transient receptor potential vanilloid type 1 antagonists: a patent review (2011 - 2014).Expert Opin Ther Pat. 2015 Mar;25(3):291-318. DM87HTO RU https://www.ncbi.nlm.nih.gov/pubmed/25666693 DMIPFO3 DI DMIPFO3 DMIPFO3 DN PMID25666693-Compound-69 DMIPFO3 MI TTMI6F5 DMIPFO3 MN Transient receptor potential cation channel V1 (TRPV1) DMIPFO3 MT DTT DMIPFO3 MA Antagonist DMIPFO3 RN Transient receptor potential vanilloid type 1 antagonists: a patent review (2011 - 2014).Expert Opin Ther Pat. 2015 Mar;25(3):291-318. DMIPFO3 RU https://www.ncbi.nlm.nih.gov/pubmed/25666693 DMNTVFH DI DMNTVFH DMNTVFH DN PMID25666693-Compound-7 DMNTVFH MI TTMI6F5 DMNTVFH MN Transient receptor potential cation channel V1 (TRPV1) DMNTVFH MT DTT DMNTVFH MA Antagonist DMNTVFH RN Transient receptor potential vanilloid type 1 antagonists: a patent review (2011 - 2014).Expert Opin Ther Pat. 2015 Mar;25(3):291-318. DMNTVFH RU https://www.ncbi.nlm.nih.gov/pubmed/25666693 DMEPYGQ DI DMEPYGQ DMEPYGQ DN PMID25666693-Compound-70 DMEPYGQ MI TTMI6F5 DMEPYGQ MN Transient receptor potential cation channel V1 (TRPV1) DMEPYGQ MT DTT DMEPYGQ MA Antagonist DMEPYGQ RN Transient receptor potential vanilloid type 1 antagonists: a patent review (2011 - 2014).Expert Opin Ther Pat. 2015 Mar;25(3):291-318. DMEPYGQ RU https://www.ncbi.nlm.nih.gov/pubmed/25666693 DM4VAQ3 DI DM4VAQ3 DM4VAQ3 DN PMID25666693-Compound-71 DM4VAQ3 MI TTMI6F5 DM4VAQ3 MN Transient receptor potential cation channel V1 (TRPV1) DM4VAQ3 MT DTT DM4VAQ3 MA Antagonist DM4VAQ3 RN Transient receptor potential vanilloid type 1 antagonists: a patent review (2011 - 2014).Expert Opin Ther Pat. 2015 Mar;25(3):291-318. DM4VAQ3 RU https://www.ncbi.nlm.nih.gov/pubmed/25666693 DMW8XD2 DI DMW8XD2 DMW8XD2 DN PMID25666693-Compound-72 DMW8XD2 MI TTMI6F5 DMW8XD2 MN Transient receptor potential cation channel V1 (TRPV1) DMW8XD2 MT DTT DMW8XD2 MA Antagonist DMW8XD2 RN Transient receptor potential vanilloid type 1 antagonists: a patent review (2011 - 2014).Expert Opin Ther Pat. 2015 Mar;25(3):291-318. DMW8XD2 RU https://www.ncbi.nlm.nih.gov/pubmed/25666693 DM9LZJ5 DI DM9LZJ5 DM9LZJ5 DN PMID25666693-Compound-73 DM9LZJ5 MI TTMI6F5 DM9LZJ5 MN Transient receptor potential cation channel V1 (TRPV1) DM9LZJ5 MT DTT DM9LZJ5 MA Antagonist DM9LZJ5 RN Transient receptor potential vanilloid type 1 antagonists: a patent review (2011 - 2014).Expert Opin Ther Pat. 2015 Mar;25(3):291-318. DM9LZJ5 RU https://www.ncbi.nlm.nih.gov/pubmed/25666693 DM80E3F DI DM80E3F DM80E3F DN PMID25666693-Compound-74 DM80E3F MI TTMI6F5 DM80E3F MN Transient receptor potential cation channel V1 (TRPV1) DM80E3F MT DTT DM80E3F MA Antagonist DM80E3F RN Transient receptor potential vanilloid type 1 antagonists: a patent review (2011 - 2014).Expert Opin Ther Pat. 2015 Mar;25(3):291-318. DM80E3F RU https://www.ncbi.nlm.nih.gov/pubmed/25666693 DMNATSQ DI DMNATSQ DMNATSQ DN PMID25666693-Compound-75 DMNATSQ MI TTMI6F5 DMNATSQ MN Transient receptor potential cation channel V1 (TRPV1) DMNATSQ MT DTT DMNATSQ MA Antagonist DMNATSQ RN Transient receptor potential vanilloid type 1 antagonists: a patent review (2011 - 2014).Expert Opin Ther Pat. 2015 Mar;25(3):291-318. DMNATSQ RU https://www.ncbi.nlm.nih.gov/pubmed/25666693 DMYH429 DI DMYH429 DMYH429 DN PMID25666693-Compound-76 DMYH429 MI TTMI6F5 DMYH429 MN Transient receptor potential cation channel V1 (TRPV1) DMYH429 MT DTT DMYH429 MA Antagonist DMYH429 RN Transient receptor potential vanilloid type 1 antagonists: a patent review (2011 - 2014).Expert Opin Ther Pat. 2015 Mar;25(3):291-318. DMYH429 RU https://www.ncbi.nlm.nih.gov/pubmed/25666693 DM05D48 DI DM05D48 DM05D48 DN PMID25666693-Compound-77 DM05D48 MI TTMI6F5 DM05D48 MN Transient receptor potential cation channel V1 (TRPV1) DM05D48 MT DTT DM05D48 MA Antagonist DM05D48 RN Transient receptor potential vanilloid type 1 antagonists: a patent review (2011 - 2014).Expert Opin Ther Pat. 2015 Mar;25(3):291-318. DM05D48 RU https://www.ncbi.nlm.nih.gov/pubmed/25666693 DMQI1YN DI DMQI1YN DMQI1YN DN PMID25666693-Compound-78 DMQI1YN MI TTMI6F5 DMQI1YN MN Transient receptor potential cation channel V1 (TRPV1) DMQI1YN MT DTT DMQI1YN MA Antagonist DMQI1YN RN Transient receptor potential vanilloid type 1 antagonists: a patent review (2011 - 2014).Expert Opin Ther Pat. 2015 Mar;25(3):291-318. DMQI1YN RU https://www.ncbi.nlm.nih.gov/pubmed/25666693 DMTQ26G DI DMTQ26G DMTQ26G DN PMID25666693-Compound-79 DMTQ26G MI TTMI6F5 DMTQ26G MN Transient receptor potential cation channel V1 (TRPV1) DMTQ26G MT DTT DMTQ26G MA Antagonist DMTQ26G RN Transient receptor potential vanilloid type 1 antagonists: a patent review (2011 - 2014).Expert Opin Ther Pat. 2015 Mar;25(3):291-318. DMTQ26G RU https://www.ncbi.nlm.nih.gov/pubmed/25666693 DMZQ6HC DI DMZQ6HC DMZQ6HC DN PMID25666693-Compound-8 DMZQ6HC MI TTMI6F5 DMZQ6HC MN Transient receptor potential cation channel V1 (TRPV1) DMZQ6HC MT DTT DMZQ6HC MA Antagonist DMZQ6HC RN Transient receptor potential vanilloid type 1 antagonists: a patent review (2011 - 2014).Expert Opin Ther Pat. 2015 Mar;25(3):291-318. DMZQ6HC RU https://www.ncbi.nlm.nih.gov/pubmed/25666693 DMB56LS DI DMB56LS DMB56LS DN PMID25666693-Compound-80 DMB56LS MI TTMI6F5 DMB56LS MN Transient receptor potential cation channel V1 (TRPV1) DMB56LS MT DTT DMB56LS MA Antagonist DMB56LS RN Transient receptor potential vanilloid type 1 antagonists: a patent review (2011 - 2014).Expert Opin Ther Pat. 2015 Mar;25(3):291-318. DMB56LS RU https://www.ncbi.nlm.nih.gov/pubmed/25666693 DM5ZELW DI DM5ZELW DM5ZELW DN PMID25666693-Compound-81 DM5ZELW MI TTMI6F5 DM5ZELW MN Transient receptor potential cation channel V1 (TRPV1) DM5ZELW MT DTT DM5ZELW MA Antagonist DM5ZELW RN Transient receptor potential vanilloid type 1 antagonists: a patent review (2011 - 2014).Expert Opin Ther Pat. 2015 Mar;25(3):291-318. DM5ZELW RU https://www.ncbi.nlm.nih.gov/pubmed/25666693 DM1MZ70 DI DM1MZ70 DM1MZ70 DN PMID25666693-Compound-82 DM1MZ70 MI TTMI6F5 DM1MZ70 MN Transient receptor potential cation channel V1 (TRPV1) DM1MZ70 MT DTT DM1MZ70 MA Antagonist DM1MZ70 RN Transient receptor potential vanilloid type 1 antagonists: a patent review (2011 - 2014).Expert Opin Ther Pat. 2015 Mar;25(3):291-318. DM1MZ70 RU https://www.ncbi.nlm.nih.gov/pubmed/25666693 DM2ZVXD DI DM2ZVXD DM2ZVXD DN PMID25666693-Compound-83 DM2ZVXD MI TTMI6F5 DM2ZVXD MN Transient receptor potential cation channel V1 (TRPV1) DM2ZVXD MT DTT DM2ZVXD MA Antagonist DM2ZVXD RN Transient receptor potential vanilloid type 1 antagonists: a patent review (2011 - 2014).Expert Opin Ther Pat. 2015 Mar;25(3):291-318. DM2ZVXD RU https://www.ncbi.nlm.nih.gov/pubmed/25666693 DM4QYIJ DI DM4QYIJ DM4QYIJ DN PMID25666693-Compound-84 DM4QYIJ MI TTMI6F5 DM4QYIJ MN Transient receptor potential cation channel V1 (TRPV1) DM4QYIJ MT DTT DM4QYIJ MA Antagonist DM4QYIJ RN Transient receptor potential vanilloid type 1 antagonists: a patent review (2011 - 2014).Expert Opin Ther Pat. 2015 Mar;25(3):291-318. DM4QYIJ RU https://www.ncbi.nlm.nih.gov/pubmed/25666693 DMGVU7M DI DMGVU7M DMGVU7M DN PMID25666693-Compound-85 DMGVU7M MI TTMI6F5 DMGVU7M MN Transient receptor potential cation channel V1 (TRPV1) DMGVU7M MT DTT DMGVU7M MA Antagonist DMGVU7M RN Transient receptor potential vanilloid type 1 antagonists: a patent review (2011 - 2014).Expert Opin Ther Pat. 2015 Mar;25(3):291-318. DMGVU7M RU https://www.ncbi.nlm.nih.gov/pubmed/25666693 DMFZ3S4 DI DMFZ3S4 DMFZ3S4 DN PMID25666693-Compound-86 DMFZ3S4 MI TTMI6F5 DMFZ3S4 MN Transient receptor potential cation channel V1 (TRPV1) DMFZ3S4 MT DTT DMFZ3S4 MA Antagonist DMFZ3S4 RN Transient receptor potential vanilloid type 1 antagonists: a patent review (2011 - 2014).Expert Opin Ther Pat. 2015 Mar;25(3):291-318. DMFZ3S4 RU https://www.ncbi.nlm.nih.gov/pubmed/25666693 DMAV4XY DI DMAV4XY DMAV4XY DN PMID25666693-Compound-87 DMAV4XY MI TTMI6F5 DMAV4XY MN Transient receptor potential cation channel V1 (TRPV1) DMAV4XY MT DTT DMAV4XY MA Antagonist DMAV4XY RN Transient receptor potential vanilloid type 1 antagonists: a patent review (2011 - 2014).Expert Opin Ther Pat. 2015 Mar;25(3):291-318. DMAV4XY RU https://www.ncbi.nlm.nih.gov/pubmed/25666693 DMT9EJL DI DMT9EJL DMT9EJL DN PMID25666693-Compound-88 DMT9EJL MI TTMI6F5 DMT9EJL MN Transient receptor potential cation channel V1 (TRPV1) DMT9EJL MT DTT DMT9EJL MA Antagonist DMT9EJL RN Transient receptor potential vanilloid type 1 antagonists: a patent review (2011 - 2014).Expert Opin Ther Pat. 2015 Mar;25(3):291-318. DMT9EJL RU https://www.ncbi.nlm.nih.gov/pubmed/25666693 DM6RQKH DI DM6RQKH DM6RQKH DN PMID25666693-Compound-89 DM6RQKH MI TTMI6F5 DM6RQKH MN Transient receptor potential cation channel V1 (TRPV1) DM6RQKH MT DTT DM6RQKH MA Antagonist DM6RQKH RN Transient receptor potential vanilloid type 1 antagonists: a patent review (2011 - 2014).Expert Opin Ther Pat. 2015 Mar;25(3):291-318. DM6RQKH RU https://www.ncbi.nlm.nih.gov/pubmed/25666693 DM8A4B5 DI DM8A4B5 DM8A4B5 DN PMID25666693-Compound-9 DM8A4B5 MI TTMI6F5 DM8A4B5 MN Transient receptor potential cation channel V1 (TRPV1) DM8A4B5 MT DTT DM8A4B5 MA Antagonist DM8A4B5 RN Transient receptor potential vanilloid type 1 antagonists: a patent review (2011 - 2014).Expert Opin Ther Pat. 2015 Mar;25(3):291-318. DM8A4B5 RU https://www.ncbi.nlm.nih.gov/pubmed/25666693 DM26NQE DI DM26NQE DM26NQE DN PMID25666693-Compound-90 DM26NQE MI TTMI6F5 DM26NQE MN Transient receptor potential cation channel V1 (TRPV1) DM26NQE MT DTT DM26NQE MA Antagonist DM26NQE RN Transient receptor potential vanilloid type 1 antagonists: a patent review (2011 - 2014).Expert Opin Ther Pat. 2015 Mar;25(3):291-318. DM26NQE RU https://www.ncbi.nlm.nih.gov/pubmed/25666693 DMXU3IE DI DMXU3IE DMXU3IE DN PMID25666693-Compound-91 DMXU3IE MI TTMI6F5 DMXU3IE MN Transient receptor potential cation channel V1 (TRPV1) DMXU3IE MT DTT DMXU3IE MA Antagonist DMXU3IE RN Transient receptor potential vanilloid type 1 antagonists: a patent review (2011 - 2014).Expert Opin Ther Pat. 2015 Mar;25(3):291-318. DMXU3IE RU https://www.ncbi.nlm.nih.gov/pubmed/25666693 DMRGOZ8 DI DMRGOZ8 DMRGOZ8 DN PMID25666693-Compound-92 DMRGOZ8 MI TTMI6F5 DMRGOZ8 MN Transient receptor potential cation channel V1 (TRPV1) DMRGOZ8 MT DTT DMRGOZ8 MA Antagonist DMRGOZ8 RN Transient receptor potential vanilloid type 1 antagonists: a patent review (2011 - 2014).Expert Opin Ther Pat. 2015 Mar;25(3):291-318. DMRGOZ8 RU https://www.ncbi.nlm.nih.gov/pubmed/25666693 DMM5EI4 DI DMM5EI4 DMM5EI4 DN PMID25666693-Compound-93 DMM5EI4 MI TTMI6F5 DMM5EI4 MN Transient receptor potential cation channel V1 (TRPV1) DMM5EI4 MT DTT DMM5EI4 MA Antagonist DMM5EI4 RN Transient receptor potential vanilloid type 1 antagonists: a patent review (2011 - 2014).Expert Opin Ther Pat. 2015 Mar;25(3):291-318. DMM5EI4 RU https://www.ncbi.nlm.nih.gov/pubmed/25666693 DMHREX9 DI DMHREX9 DMHREX9 DN PMID25666693-Compound-94 DMHREX9 MI TTMI6F5 DMHREX9 MN Transient receptor potential cation channel V1 (TRPV1) DMHREX9 MT DTT DMHREX9 MA Antagonist DMHREX9 RN Transient receptor potential vanilloid type 1 antagonists: a patent review (2011 - 2014).Expert Opin Ther Pat. 2015 Mar;25(3):291-318. DMHREX9 RU https://www.ncbi.nlm.nih.gov/pubmed/25666693 DMFNB1T DI DMFNB1T DMFNB1T DN PMID25666693-Compound-95 DMFNB1T MI TTMI6F5 DMFNB1T MN Transient receptor potential cation channel V1 (TRPV1) DMFNB1T MT DTT DMFNB1T MA Antagonist DMFNB1T RN Transient receptor potential vanilloid type 1 antagonists: a patent review (2011 - 2014).Expert Opin Ther Pat. 2015 Mar;25(3):291-318. DMFNB1T RU https://www.ncbi.nlm.nih.gov/pubmed/25666693 DME3NTB DI DME3NTB DME3NTB DN PMID25666693-Compound-96 DME3NTB MI TTMI6F5 DME3NTB MN Transient receptor potential cation channel V1 (TRPV1) DME3NTB MT DTT DME3NTB MA Antagonist DME3NTB RN Transient receptor potential vanilloid type 1 antagonists: a patent review (2011 - 2014).Expert Opin Ther Pat. 2015 Mar;25(3):291-318. DME3NTB RU https://www.ncbi.nlm.nih.gov/pubmed/25666693 DMHJOP7 DI DMHJOP7 DMHJOP7 DN PMID25666693-Compound-97 DMHJOP7 MI TTMI6F5 DMHJOP7 MN Transient receptor potential cation channel V1 (TRPV1) DMHJOP7 MT DTT DMHJOP7 MA Antagonist DMHJOP7 RN Transient receptor potential vanilloid type 1 antagonists: a patent review (2011 - 2014).Expert Opin Ther Pat. 2015 Mar;25(3):291-318. DMHJOP7 RU https://www.ncbi.nlm.nih.gov/pubmed/25666693 DM2ZR8M DI DM2ZR8M DM2ZR8M DN PMID25666693-Compound-98 DM2ZR8M MI TTMI6F5 DM2ZR8M MN Transient receptor potential cation channel V1 (TRPV1) DM2ZR8M MT DTT DM2ZR8M MA Antagonist DM2ZR8M RN Transient receptor potential vanilloid type 1 antagonists: a patent review (2011 - 2014).Expert Opin Ther Pat. 2015 Mar;25(3):291-318. DM2ZR8M RU https://www.ncbi.nlm.nih.gov/pubmed/25666693 DMOISDH DI DMOISDH DMOISDH DN PMID25666693-Compound-99 DMOISDH MI TTMI6F5 DMOISDH MN Transient receptor potential cation channel V1 (TRPV1) DMOISDH MT DTT DMOISDH MA Antagonist DMOISDH RN Transient receptor potential vanilloid type 1 antagonists: a patent review (2011 - 2014).Expert Opin Ther Pat. 2015 Mar;25(3):291-318. DMOISDH RU https://www.ncbi.nlm.nih.gov/pubmed/25666693 DMDZT7Y DI DMDZT7Y DMDZT7Y DN PMID25684022-Compound-EP20041486488 DMDZT7Y MI TTCZOF2 DMDZT7Y MN Pyruvate dehydrogenase kinase 1 (PDHK1) DMDZT7Y MT DTT DMDZT7Y MA Inhibitor DMDZT7Y RN PDK1 disruptors and modulators: a patent review.Expert Opin Ther Pat. 2015 May;25(5):513-37. DMDZT7Y RU https://www.ncbi.nlm.nih.gov/pubmed/25684022 DMR4MSH DI DMR4MSH DMR4MSH DN PMID25684022-Compound-US20120277229 39(1.1) DMR4MSH MI TTCZOF2 DMR4MSH MN Pyruvate dehydrogenase kinase 1 (PDHK1) DMR4MSH MT DTT DMR4MSH MA Inhibitor DMR4MSH RN PDK1 disruptors and modulators: a patent review.Expert Opin Ther Pat. 2015 May;25(5):513-37. DMR4MSH RU https://www.ncbi.nlm.nih.gov/pubmed/25684022 DMR3J9A DI DMR3J9A DMR3J9A DN PMID25684022-Compound-US20120277229 40(1.2) DMR3J9A MI TTCZOF2 DMR3J9A MN Pyruvate dehydrogenase kinase 1 (PDHK1) DMR3J9A MT DTT DMR3J9A MA Inhibitor DMR3J9A RN PDK1 disruptors and modulators: a patent review.Expert Opin Ther Pat. 2015 May;25(5):513-37. DMR3J9A RU https://www.ncbi.nlm.nih.gov/pubmed/25684022 DM7V6E0 DI DM7V6E0 DM7V6E0 DN PMID25684022-Compound-US20120277229 41(1.3) DM7V6E0 MI TTCZOF2 DM7V6E0 MN Pyruvate dehydrogenase kinase 1 (PDHK1) DM7V6E0 MT DTT DM7V6E0 MA Inhibitor DM7V6E0 RN PDK1 disruptors and modulators: a patent review.Expert Opin Ther Pat. 2015 May;25(5):513-37. DM7V6E0 RU https://www.ncbi.nlm.nih.gov/pubmed/25684022 DMUQ04C DI DMUQ04C DMUQ04C DN PMID25684022-Compound-US20120277229 44(1.4) DMUQ04C MI TTCZOF2 DMUQ04C MN Pyruvate dehydrogenase kinase 1 (PDHK1) DMUQ04C MT DTT DMUQ04C MA Inhibitor DMUQ04C RN PDK1 disruptors and modulators: a patent review.Expert Opin Ther Pat. 2015 May;25(5):513-37. DMUQ04C RU https://www.ncbi.nlm.nih.gov/pubmed/25684022 DMEIA6Y DI DMEIA6Y DMEIA6Y DN PMID25684022-Compound-US20120277229 45(1.5) DMEIA6Y MI TTCZOF2 DMEIA6Y MN Pyruvate dehydrogenase kinase 1 (PDHK1) DMEIA6Y MT DTT DMEIA6Y MA Inhibitor DMEIA6Y RN PDK1 disruptors and modulators: a patent review.Expert Opin Ther Pat. 2015 May;25(5):513-37. DMEIA6Y RU https://www.ncbi.nlm.nih.gov/pubmed/25684022 DMDHJMU DI DMDHJMU DMDHJMU DN PMID25684022-Compound-US20130053382 35(1-11) DMDHJMU MI TTCZOF2 DMDHJMU MN Pyruvate dehydrogenase kinase 1 (PDHK1) DMDHJMU MT DTT DMDHJMU MA Inhibitor DMDHJMU RN PDK1 disruptors and modulators: a patent review.Expert Opin Ther Pat. 2015 May;25(5):513-37. DMDHJMU RU https://www.ncbi.nlm.nih.gov/pubmed/25684022 DM40FVN DI DM40FVN DM40FVN DN PMID25684022-Compound-US20130053382 36(3-5) DM40FVN MI TTCZOF2 DM40FVN MN Pyruvate dehydrogenase kinase 1 (PDHK1) DM40FVN MT DTT DM40FVN MA Inhibitor DM40FVN RN PDK1 disruptors and modulators: a patent review.Expert Opin Ther Pat. 2015 May;25(5):513-37. DM40FVN RU https://www.ncbi.nlm.nih.gov/pubmed/25684022 DMY7Z85 DI DMY7Z85 DMY7Z85 DN PMID25684022-Compound-US20130053382 37(4-6) DMY7Z85 MI TTCZOF2 DMY7Z85 MN Pyruvate dehydrogenase kinase 1 (PDHK1) DMY7Z85 MT DTT DMY7Z85 MA Inhibitor DMY7Z85 RN PDK1 disruptors and modulators: a patent review.Expert Opin Ther Pat. 2015 May;25(5):513-37. DMY7Z85 RU https://www.ncbi.nlm.nih.gov/pubmed/25684022 DMHLQ2T DI DMHLQ2T DMHLQ2T DN PMID25684022-Compound-US20130053382 38(5-7) DMHLQ2T MI TTCZOF2 DMHLQ2T MN Pyruvate dehydrogenase kinase 1 (PDHK1) DMHLQ2T MT DTT DMHLQ2T MA Inhibitor DMHLQ2T RN PDK1 disruptors and modulators: a patent review.Expert Opin Ther Pat. 2015 May;25(5):513-37. DMHLQ2T RU https://www.ncbi.nlm.nih.gov/pubmed/25684022 DM809AX DI DM809AX DM809AX DN PMID25684022-Compound-WO2004087707 DM809AX MI TTCZOF2 DM809AX MN Pyruvate dehydrogenase kinase 1 (PDHK1) DM809AX MT DTT DM809AX MA Inhibitor DM809AX RN PDK1 disruptors and modulators: a patent review.Expert Opin Ther Pat. 2015 May;25(5):513-37. DM809AX RU https://www.ncbi.nlm.nih.gov/pubmed/25684022 DMV7PNF DI DMV7PNF DMV7PNF DN PMID25684022-Compound-WO2006015124 DMV7PNF MI TTCZOF2 DMV7PNF MN Pyruvate dehydrogenase kinase 1 (PDHK1) DMV7PNF MT DTT DMV7PNF MA Inhibitor DMV7PNF RN PDK1 disruptors and modulators: a patent review.Expert Opin Ther Pat. 2015 May;25(5):513-37. DMV7PNF RU https://www.ncbi.nlm.nih.gov/pubmed/25684022 DMDMJYL DI DMDMJYL DMDMJYL DN PMID25684022-Compound-WO2008005457 DMDMJYL MI TTCZOF2 DMDMJYL MN Pyruvate dehydrogenase kinase 1 (PDHK1) DMDMJYL MT DTT DMDMJYL MA Inhibitor DMDMJYL RN PDK1 disruptors and modulators: a patent review.Expert Opin Ther Pat. 2015 May;25(5):513-37. DMDMJYL RU https://www.ncbi.nlm.nih.gov/pubmed/25684022 DMKJ1HC DI DMKJ1HC DMKJ1HC DN PMID25684022-Compound-WO2008079988 DMKJ1HC MI TTCZOF2 DMKJ1HC MN Pyruvate dehydrogenase kinase 1 (PDHK1) DMKJ1HC MT DTT DMKJ1HC MA Inhibitor DMKJ1HC RN PDK1 disruptors and modulators: a patent review.Expert Opin Ther Pat. 2015 May;25(5):513-37. DMKJ1HC RU https://www.ncbi.nlm.nih.gov/pubmed/25684022 DM8L5JR DI DM8L5JR DM8L5JR DN PMID25684022-Compound-WO2008107444 DM8L5JR MI TTCZOF2 DM8L5JR MN Pyruvate dehydrogenase kinase 1 (PDHK1) DM8L5JR MT DTT DM8L5JR MA Inhibitor DM8L5JR RN PDK1 disruptors and modulators: a patent review.Expert Opin Ther Pat. 2015 May;25(5):513-37. DM8L5JR RU https://www.ncbi.nlm.nih.gov/pubmed/25684022 DMTP02Q DI DMTP02Q DMTP02Q DN PMID25684022-Compound-WO2009153313 DMTP02Q MI TTCZOF2 DMTP02Q MN Pyruvate dehydrogenase kinase 1 (PDHK1) DMTP02Q MT DTT DMTP02Q MA Inhibitor DMTP02Q RN PDK1 disruptors and modulators: a patent review.Expert Opin Ther Pat. 2015 May;25(5):513-37. DMTP02Q RU https://www.ncbi.nlm.nih.gov/pubmed/25684022 DM37FDV DI DM37FDV DM37FDV DN PMID25684022-Compound-WO2010127754 DM37FDV MI TTCZOF2 DM37FDV MN Pyruvate dehydrogenase kinase 1 (PDHK1) DM37FDV MT DTT DM37FDV MA Inhibitor DM37FDV RN PDK1 disruptors and modulators: a patent review.Expert Opin Ther Pat. 2015 May;25(5):513-37. DM37FDV RU https://www.ncbi.nlm.nih.gov/pubmed/25684022 DM3IZ0H DI DM3IZ0H DM3IZ0H DN PMID25684022-Compound-WO2011137219 35(1-11) DM3IZ0H MI TTCZOF2 DM3IZ0H MN Pyruvate dehydrogenase kinase 1 (PDHK1) DM3IZ0H MT DTT DM3IZ0H MA Inhibitor DM3IZ0H RN PDK1 disruptors and modulators: a patent review.Expert Opin Ther Pat. 2015 May;25(5):513-37. DM3IZ0H RU https://www.ncbi.nlm.nih.gov/pubmed/25684022 DMAQHI5 DI DMAQHI5 DMAQHI5 DN PMID25684022-Compound-WO2011137219 36(3-5) DMAQHI5 MI TTCZOF2 DMAQHI5 MN Pyruvate dehydrogenase kinase 1 (PDHK1) DMAQHI5 MT DTT DMAQHI5 MA Inhibitor DMAQHI5 RN PDK1 disruptors and modulators: a patent review.Expert Opin Ther Pat. 2015 May;25(5):513-37. DMAQHI5 RU https://www.ncbi.nlm.nih.gov/pubmed/25684022 DMSQ5J8 DI DMSQ5J8 DMSQ5J8 DN PMID25684022-Compound-WO2011137219 37(4-6) DMSQ5J8 MI TTCZOF2 DMSQ5J8 MN Pyruvate dehydrogenase kinase 1 (PDHK1) DMSQ5J8 MT DTT DMSQ5J8 MA Inhibitor DMSQ5J8 RN PDK1 disruptors and modulators: a patent review.Expert Opin Ther Pat. 2015 May;25(5):513-37. DMSQ5J8 RU https://www.ncbi.nlm.nih.gov/pubmed/25684022 DM4NXBK DI DM4NXBK DM4NXBK DN PMID25684022-Compound-WO2011137219 38(5-7) DM4NXBK MI TTCZOF2 DM4NXBK MN Pyruvate dehydrogenase kinase 1 (PDHK1) DM4NXBK MT DTT DM4NXBK MA Inhibitor DM4NXBK RN PDK1 disruptors and modulators: a patent review.Expert Opin Ther Pat. 2015 May;25(5):513-37. DM4NXBK RU https://www.ncbi.nlm.nih.gov/pubmed/25684022 DMSDRA4 DI DMSDRA4 DMSDRA4 DN PMID25684022-Compound-WO2012135799 42(1.4) DMSDRA4 MI TTCZOF2 DMSDRA4 MN Pyruvate dehydrogenase kinase 1 (PDHK1) DMSDRA4 MT DTT DMSDRA4 MA Inhibitor DMSDRA4 RN PDK1 disruptors and modulators: a patent review.Expert Opin Ther Pat. 2015 May;25(5):513-37. DMSDRA4 RU https://www.ncbi.nlm.nih.gov/pubmed/25684022 DMHI3O1 DI DMHI3O1 DMHI3O1 DN PMID25684022-Compound-WO2012135799 43(1.5) DMHI3O1 MI TTCZOF2 DMHI3O1 MN Pyruvate dehydrogenase kinase 1 (PDHK1) DMHI3O1 MT DTT DMHI3O1 MA Inhibitor DMHI3O1 RN PDK1 disruptors and modulators: a patent review.Expert Opin Ther Pat. 2015 May;25(5):513-37. DMHI3O1 RU https://www.ncbi.nlm.nih.gov/pubmed/25684022 DMZ73D9 DI DMZ73D9 DMZ73D9 DN PMID25726713-Compound-10 DMZ73D9 MI TT8J1S3 DMZ73D9 MN Smoothened homolog (SMO) DMZ73D9 MT DTT DMZ73D9 MA Inhibitor DMZ73D9 RN Hedgehog inhibitors: a patent review (2013 - present).Expert Opin Ther Pat. 2015 May;25(5):549-65. DMZ73D9 RU https://www.ncbi.nlm.nih.gov/pubmed/25726713 DMN42OT DI DMN42OT DMN42OT DN PMID25726713-Compound-11 DMN42OT MI TT8J1S3 DMN42OT MN Smoothened homolog (SMO) DMN42OT MT DTT DMN42OT MA Inhibitor DMN42OT RN Hedgehog inhibitors: a patent review (2013 - present).Expert Opin Ther Pat. 2015 May;25(5):549-65. DMN42OT RU https://www.ncbi.nlm.nih.gov/pubmed/25726713 DMD3AHN DI DMD3AHN DMD3AHN DN PMID25726713-Compound-12 DMD3AHN MI TT8J1S3 DMD3AHN MN Smoothened homolog (SMO) DMD3AHN MT DTT DMD3AHN MA Inhibitor DMD3AHN RN Hedgehog inhibitors: a patent review (2013 - present).Expert Opin Ther Pat. 2015 May;25(5):549-65. DMD3AHN RU https://www.ncbi.nlm.nih.gov/pubmed/25726713 DM8LZ60 DI DM8LZ60 DM8LZ60 DN PMID25726713-Compound-13 DM8LZ60 MI TT8J1S3 DM8LZ60 MN Smoothened homolog (SMO) DM8LZ60 MT DTT DM8LZ60 MA Inhibitor DM8LZ60 RN Hedgehog inhibitors: a patent review (2013 - present).Expert Opin Ther Pat. 2015 May;25(5):549-65. DM8LZ60 RU https://www.ncbi.nlm.nih.gov/pubmed/25726713 DM6ORB9 DI DM6ORB9 DM6ORB9 DN PMID25726713-Compound-14 DM6ORB9 MI TT8J1S3 DM6ORB9 MN Smoothened homolog (SMO) DM6ORB9 MT DTT DM6ORB9 MA Inhibitor DM6ORB9 RN Hedgehog inhibitors: a patent review (2013 - present).Expert Opin Ther Pat. 2015 May;25(5):549-65. DM6ORB9 RU https://www.ncbi.nlm.nih.gov/pubmed/25726713 DM67WM4 DI DM67WM4 DM67WM4 DN PMID25726713-Compound-15 DM67WM4 MI TT8J1S3 DM67WM4 MN Smoothened homolog (SMO) DM67WM4 MT DTT DM67WM4 MA Inhibitor DM67WM4 RN Hedgehog inhibitors: a patent review (2013 - present).Expert Opin Ther Pat. 2015 May;25(5):549-65. DM67WM4 RU https://www.ncbi.nlm.nih.gov/pubmed/25726713 DM3BOZP DI DM3BOZP DM3BOZP DN PMID25726713-Compound-16 DM3BOZP MI TT8J1S3 DM3BOZP MN Smoothened homolog (SMO) DM3BOZP MT DTT DM3BOZP MA Inhibitor DM3BOZP RN Hedgehog inhibitors: a patent review (2013 - present).Expert Opin Ther Pat. 2015 May;25(5):549-65. DM3BOZP RU https://www.ncbi.nlm.nih.gov/pubmed/25726713 DM9MFUN DI DM9MFUN DM9MFUN DN PMID25726713-Compound-17 DM9MFUN MI TTW6JVU DM9MFUN MN Smoothened D473H mutant (SMO D473H) DM9MFUN MT DTT DM9MFUN MA Antagonist DM9MFUN RN Hedgehog inhibitors: a patent review (2013 - present).Expert Opin Ther Pat. 2015 May;25(5):549-65. DM9MFUN RU https://www.ncbi.nlm.nih.gov/pubmed/25726713 DM9MFUN DI DM9MFUN DM9MFUN DN PMID25726713-Compound-17 DM9MFUN MI TT8J1S3 DM9MFUN MN Smoothened homolog (SMO) DM9MFUN MT DTT DM9MFUN MA Antagonist DM9MFUN RN Hedgehog inhibitors: a patent review (2013 - present).Expert Opin Ther Pat. 2015 May;25(5):549-65. DM9MFUN RU https://www.ncbi.nlm.nih.gov/pubmed/25726713 DMP7C5L DI DMP7C5L DMP7C5L DN PMID25726713-Compound-18 DMP7C5L MI TT8J1S3 DMP7C5L MN Smoothened homolog (SMO) DMP7C5L MT DTT DMP7C5L MA Antagonist DMP7C5L RN Hedgehog inhibitors: a patent review (2013 - present).Expert Opin Ther Pat. 2015 May;25(5):549-65. DMP7C5L RU https://www.ncbi.nlm.nih.gov/pubmed/25726713 DMQJZLI DI DMQJZLI DMQJZLI DN PMID25726713-Compound-19 DMQJZLI MI TT8J1S3 DMQJZLI MN Smoothened homolog (SMO) DMQJZLI MT DTT DMQJZLI MA Inhibitor DMQJZLI RN Hedgehog inhibitors: a patent review (2013 - present).Expert Opin Ther Pat. 2015 May;25(5):549-65. DMQJZLI RU https://www.ncbi.nlm.nih.gov/pubmed/25726713 DMZOG9S DI DMZOG9S DMZOG9S DN PMID25726713-Compound-20 DMZOG9S MI TT8J1S3 DMZOG9S MN Smoothened homolog (SMO) DMZOG9S MT DTT DMZOG9S MA Inhibitor DMZOG9S RN Hedgehog inhibitors: a patent review (2013 - present).Expert Opin Ther Pat. 2015 May;25(5):549-65. DMZOG9S RU https://www.ncbi.nlm.nih.gov/pubmed/25726713 DMB0DS5 DI DMB0DS5 DMB0DS5 DN PMID25726713-Compound-21 DMB0DS5 MI TT8J1S3 DMB0DS5 MN Smoothened homolog (SMO) DMB0DS5 MT DTT DMB0DS5 MA Inhibitor DMB0DS5 RN Hedgehog inhibitors: a patent review (2013 - present).Expert Opin Ther Pat. 2015 May;25(5):549-65. DMB0DS5 RU https://www.ncbi.nlm.nih.gov/pubmed/25726713 DMJUHXB DI DMJUHXB DMJUHXB DN PMID25726713-Compound-22 DMJUHXB MI TT8J1S3 DMJUHXB MN Smoothened homolog (SMO) DMJUHXB MT DTT DMJUHXB MA Inhibitor DMJUHXB RN Hedgehog inhibitors: a patent review (2013 - present).Expert Opin Ther Pat. 2015 May;25(5):549-65. DMJUHXB RU https://www.ncbi.nlm.nih.gov/pubmed/25726713 DMEXNOP DI DMEXNOP DMEXNOP DN PMID25726713-Compound-23 DMEXNOP MI TT8J1S3 DMEXNOP MN Smoothened homolog (SMO) DMEXNOP MT DTT DMEXNOP MA Inhibitor DMEXNOP RN Hedgehog inhibitors: a patent review (2013 - present).Expert Opin Ther Pat. 2015 May;25(5):549-65. DMEXNOP RU https://www.ncbi.nlm.nih.gov/pubmed/25726713 DMMFK2Q DI DMMFK2Q DMMFK2Q DN PMID25726713-Compound-24 DMMFK2Q MI TT8J1S3 DMMFK2Q MN Smoothened homolog (SMO) DMMFK2Q MT DTT DMMFK2Q MA Inhibitor DMMFK2Q RN Hedgehog inhibitors: a patent review (2013 - present).Expert Opin Ther Pat. 2015 May;25(5):549-65. DMMFK2Q RU https://www.ncbi.nlm.nih.gov/pubmed/25726713 DMLCPWT DI DMLCPWT DMLCPWT DN PMID25726713-Compound-25 DMLCPWT MI TT8J1S3 DMLCPWT MN Smoothened homolog (SMO) DMLCPWT MT DTT DMLCPWT MA Inhibitor DMLCPWT RN Hedgehog inhibitors: a patent review (2013 - present).Expert Opin Ther Pat. 2015 May;25(5):549-65. DMLCPWT RU https://www.ncbi.nlm.nih.gov/pubmed/25726713 DMJ8MXZ DI DMJ8MXZ DMJ8MXZ DN PMID25726713-Compound-26 DMJ8MXZ MI TT8J1S3 DMJ8MXZ MN Smoothened homolog (SMO) DMJ8MXZ MT DTT DMJ8MXZ MA Inhibitor DMJ8MXZ RN Hedgehog inhibitors: a patent review (2013 - present).Expert Opin Ther Pat. 2015 May;25(5):549-65. DMJ8MXZ RU https://www.ncbi.nlm.nih.gov/pubmed/25726713 DMTL73W DI DMTL73W DMTL73W DN PMID25726713-Compound-27 DMTL73W MI TT8J1S3 DMTL73W MN Smoothened homolog (SMO) DMTL73W MT DTT DMTL73W MA Inhibitor DMTL73W RN Hedgehog inhibitors: a patent review (2013 - present).Expert Opin Ther Pat. 2015 May;25(5):549-65. DMTL73W RU https://www.ncbi.nlm.nih.gov/pubmed/25726713 DMYM60P DI DMYM60P DMYM60P DN PMID25726713-Compound-28 DMYM60P MI TT8J1S3 DMYM60P MN Smoothened homolog (SMO) DMYM60P MT DTT DMYM60P MA Inhibitor DMYM60P RN Hedgehog inhibitors: a patent review (2013 - present).Expert Opin Ther Pat. 2015 May;25(5):549-65. DMYM60P RU https://www.ncbi.nlm.nih.gov/pubmed/25726713 DM3QU80 DI DM3QU80 DM3QU80 DN PMID25726713-Compound-29 DM3QU80 MI TT8J1S3 DM3QU80 MN Smoothened homolog (SMO) DM3QU80 MT DTT DM3QU80 MA Inhibitor DM3QU80 RN Hedgehog inhibitors: a patent review (2013 - present).Expert Opin Ther Pat. 2015 May;25(5):549-65. DM3QU80 RU https://www.ncbi.nlm.nih.gov/pubmed/25726713 DMFBHAC DI DMFBHAC DMFBHAC DN PMID25726713-Compound-30 DMFBHAC MI TT8J1S3 DMFBHAC MN Smoothened homolog (SMO) DMFBHAC MT DTT DMFBHAC MA Inhibitor DMFBHAC RN Hedgehog inhibitors: a patent review (2013 - present).Expert Opin Ther Pat. 2015 May;25(5):549-65. DMFBHAC RU https://www.ncbi.nlm.nih.gov/pubmed/25726713 DMN13BI DI DMN13BI DMN13BI DN PMID25726713-Compound-31 DMN13BI MI TT8J1S3 DMN13BI MN Smoothened homolog (SMO) DMN13BI MT DTT DMN13BI MA Inhibitor DMN13BI RN Hedgehog inhibitors: a patent review (2013 - present).Expert Opin Ther Pat. 2015 May;25(5):549-65. DMN13BI RU https://www.ncbi.nlm.nih.gov/pubmed/25726713 DMIFH8T DI DMIFH8T DMIFH8T DN PMID25726713-Compound-32 DMIFH8T MI TT8J1S3 DMIFH8T MN Smoothened homolog (SMO) DMIFH8T MT DTT DMIFH8T MA Inhibitor DMIFH8T RN Hedgehog inhibitors: a patent review (2013 - present).Expert Opin Ther Pat. 2015 May;25(5):549-65. DMIFH8T RU https://www.ncbi.nlm.nih.gov/pubmed/25726713 DMEQ9BN DI DMEQ9BN DMEQ9BN DN PMID25726713-Compound-33 DMEQ9BN MI TT8J1S3 DMEQ9BN MN Smoothened homolog (SMO) DMEQ9BN MT DTT DMEQ9BN MA Inhibitor DMEQ9BN RN Hedgehog inhibitors: a patent review (2013 - present).Expert Opin Ther Pat. 2015 May;25(5):549-65. DMEQ9BN RU https://www.ncbi.nlm.nih.gov/pubmed/25726713 DMCXDKS DI DMCXDKS DMCXDKS DN PMID25726713-Compound-34 DMCXDKS MI TT8J1S3 DMCXDKS MN Smoothened homolog (SMO) DMCXDKS MT DTT DMCXDKS MA Inhibitor DMCXDKS RN Hedgehog inhibitors: a patent review (2013 - present).Expert Opin Ther Pat. 2015 May;25(5):549-65. DMCXDKS RU https://www.ncbi.nlm.nih.gov/pubmed/25726713 DMYCABN DI DMYCABN DMYCABN DN PMID25726713-Compound-35 DMYCABN MI TT8J1S3 DMYCABN MN Smoothened homolog (SMO) DMYCABN MT DTT DMYCABN MA Inhibitor DMYCABN RN Hedgehog inhibitors: a patent review (2013 - present).Expert Opin Ther Pat. 2015 May;25(5):549-65. DMYCABN RU https://www.ncbi.nlm.nih.gov/pubmed/25726713 DMYPT63 DI DMYPT63 DMYPT63 DN PMID25726713-Compound-36 DMYPT63 MI TT8J1S3 DMYPT63 MN Smoothened homolog (SMO) DMYPT63 MT DTT DMYPT63 MA Inhibitor DMYPT63 RN Hedgehog inhibitors: a patent review (2013 - present).Expert Opin Ther Pat. 2015 May;25(5):549-65. DMYPT63 RU https://www.ncbi.nlm.nih.gov/pubmed/25726713 DMGXOJK DI DMGXOJK DMGXOJK DN PMID25726713-Compound-37 DMGXOJK MI TT8J1S3 DMGXOJK MN Smoothened homolog (SMO) DMGXOJK MT DTT DMGXOJK MA Inhibitor DMGXOJK RN Hedgehog inhibitors: a patent review (2013 - present).Expert Opin Ther Pat. 2015 May;25(5):549-65. DMGXOJK RU https://www.ncbi.nlm.nih.gov/pubmed/25726713 DM4XJST DI DM4XJST DM4XJST DN PMID25726713-Compound-38 DM4XJST MI TT8J1S3 DM4XJST MN Smoothened homolog (SMO) DM4XJST MT DTT DM4XJST MA Inhibitor DM4XJST RN Hedgehog inhibitors: a patent review (2013 - present).Expert Opin Ther Pat. 2015 May;25(5):549-65. DM4XJST RU https://www.ncbi.nlm.nih.gov/pubmed/25726713 DMVL25C DI DMVL25C DMVL25C DN PMID25726713-Compound-39 DMVL25C MI TT8J1S3 DMVL25C MN Smoothened homolog (SMO) DMVL25C MT DTT DMVL25C MA Inhibitor DMVL25C RN Hedgehog inhibitors: a patent review (2013 - present).Expert Opin Ther Pat. 2015 May;25(5):549-65. DMVL25C RU https://www.ncbi.nlm.nih.gov/pubmed/25726713 DM5E2B3 DI DM5E2B3 DM5E2B3 DN PMID25726713-Compound-42 DM5E2B3 MI TT8J1S3 DM5E2B3 MN Smoothened homolog (SMO) DM5E2B3 MT DTT DM5E2B3 MA Inhibitor DM5E2B3 RN Hedgehog inhibitors: a patent review (2013 - present).Expert Opin Ther Pat. 2015 May;25(5):549-65. DM5E2B3 RU https://www.ncbi.nlm.nih.gov/pubmed/25726713 DME9QCM DI DME9QCM DME9QCM DN PMID25726713-Compound-43 DME9QCM MI TT8J1S3 DME9QCM MN Smoothened homolog (SMO) DME9QCM MT DTT DME9QCM MA Inhibitor DME9QCM RN Hedgehog inhibitors: a patent review (2013 - present).Expert Opin Ther Pat. 2015 May;25(5):549-65. DME9QCM RU https://www.ncbi.nlm.nih.gov/pubmed/25726713 DMEFA20 DI DMEFA20 DMEFA20 DN PMID25726713-Compound-44 DMEFA20 MI TT8J1S3 DMEFA20 MN Smoothened homolog (SMO) DMEFA20 MT DTT DMEFA20 MA Inhibitor DMEFA20 RN Hedgehog inhibitors: a patent review (2013 - present).Expert Opin Ther Pat. 2015 May;25(5):549-65. DMEFA20 RU https://www.ncbi.nlm.nih.gov/pubmed/25726713 DMR8OVI DI DMR8OVI DMR8OVI DN PMID25726713-Compound-45 DMR8OVI MI TT8J1S3 DMR8OVI MN Smoothened homolog (SMO) DMR8OVI MT DTT DMR8OVI MA Inhibitor DMR8OVI RN Hedgehog inhibitors: a patent review (2013 - present).Expert Opin Ther Pat. 2015 May;25(5):549-65. DMR8OVI RU https://www.ncbi.nlm.nih.gov/pubmed/25726713 DM27DQP DI DM27DQP DM27DQP DN PMID25726713-Compound-46 DM27DQP MI TT8J1S3 DM27DQP MN Smoothened homolog (SMO) DM27DQP MT DTT DM27DQP MA Inhibitor DM27DQP RN Hedgehog inhibitors: a patent review (2013 - present).Expert Opin Ther Pat. 2015 May;25(5):549-65. DM27DQP RU https://www.ncbi.nlm.nih.gov/pubmed/25726713 DMXE5KM DI DMXE5KM DMXE5KM DN PMID25726713-Compound-47 DMXE5KM MI TT0PG8F DMXE5KM MN Cyclin-dependent kinase 4 (CDK4) DMXE5KM MT DTT DMXE5KM MA Inhibitor DMXE5KM RN Hedgehog inhibitors: a patent review (2013 - present).Expert Opin Ther Pat. 2015 May;25(5):549-65. DMXE5KM RU https://www.ncbi.nlm.nih.gov/pubmed/25726713 DMXE5KM DI DMXE5KM DMXE5KM DN PMID25726713-Compound-47 DMXE5KM MI TTO0FDJ DMXE5KM MN Cyclin-dependent kinase 6 (CDK6) DMXE5KM MT DTT DMXE5KM MA Inhibitor DMXE5KM RN Hedgehog inhibitors: a patent review (2013 - present).Expert Opin Ther Pat. 2015 May;25(5):549-65. DMXE5KM RU https://www.ncbi.nlm.nih.gov/pubmed/25726713 DMXE5KM DI DMXE5KM DMXE5KM DN PMID25726713-Compound-47 DMXE5KM MI TTCJG29 DMXE5KM MN Serine/threonine-protein kinase mTOR (mTOR) DMXE5KM MT DTT DMXE5KM MA Inhibitor DMXE5KM RN Hedgehog inhibitors: a patent review (2013 - present).Expert Opin Ther Pat. 2015 May;25(5):549-65. DMXE5KM RU https://www.ncbi.nlm.nih.gov/pubmed/25726713 DMXE5KM DI DMXE5KM DMXE5KM DN PMID25726713-Compound-47 DMXE5KM MI TT8J1S3 DMXE5KM MN Smoothened homolog (SMO) DMXE5KM MT DTT DMXE5KM MA Inhibitor DMXE5KM RN Hedgehog inhibitors: a patent review (2013 - present).Expert Opin Ther Pat. 2015 May;25(5):549-65. DMXE5KM RU https://www.ncbi.nlm.nih.gov/pubmed/25726713 DMSIOUA DI DMSIOUA DMSIOUA DN PMID25726713-Compound-48 DMSIOUA MI TT0PG8F DMSIOUA MN Cyclin-dependent kinase 4 (CDK4) DMSIOUA MT DTT DMSIOUA MA Inhibitor DMSIOUA RN Hedgehog inhibitors: a patent review (2013 - present).Expert Opin Ther Pat. 2015 May;25(5):549-65. DMSIOUA RU https://www.ncbi.nlm.nih.gov/pubmed/25726713 DMSIOUA DI DMSIOUA DMSIOUA DN PMID25726713-Compound-48 DMSIOUA MI TTO0FDJ DMSIOUA MN Cyclin-dependent kinase 6 (CDK6) DMSIOUA MT DTT DMSIOUA MA Inhibitor DMSIOUA RN Hedgehog inhibitors: a patent review (2013 - present).Expert Opin Ther Pat. 2015 May;25(5):549-65. DMSIOUA RU https://www.ncbi.nlm.nih.gov/pubmed/25726713 DMSIOUA DI DMSIOUA DMSIOUA DN PMID25726713-Compound-48 DMSIOUA MI TTCJG29 DMSIOUA MN Serine/threonine-protein kinase mTOR (mTOR) DMSIOUA MT DTT DMSIOUA MA Inhibitor DMSIOUA RN Hedgehog inhibitors: a patent review (2013 - present).Expert Opin Ther Pat. 2015 May;25(5):549-65. DMSIOUA RU https://www.ncbi.nlm.nih.gov/pubmed/25726713 DMSIOUA DI DMSIOUA DMSIOUA DN PMID25726713-Compound-48 DMSIOUA MI TT8J1S3 DMSIOUA MN Smoothened homolog (SMO) DMSIOUA MT DTT DMSIOUA MA Inhibitor DMSIOUA RN Hedgehog inhibitors: a patent review (2013 - present).Expert Opin Ther Pat. 2015 May;25(5):549-65. DMSIOUA RU https://www.ncbi.nlm.nih.gov/pubmed/25726713 DM2CT4G DI DM2CT4G DM2CT4G DN PMID25726713-Compound-49 DM2CT4G MI TT0PG8F DM2CT4G MN Cyclin-dependent kinase 4 (CDK4) DM2CT4G MT DTT DM2CT4G MA Inhibitor DM2CT4G RN Hedgehog inhibitors: a patent review (2013 - present).Expert Opin Ther Pat. 2015 May;25(5):549-65. DM2CT4G RU https://www.ncbi.nlm.nih.gov/pubmed/25726713 DM2CT4G DI DM2CT4G DM2CT4G DN PMID25726713-Compound-49 DM2CT4G MI TTO0FDJ DM2CT4G MN Cyclin-dependent kinase 6 (CDK6) DM2CT4G MT DTT DM2CT4G MA Inhibitor DM2CT4G RN Hedgehog inhibitors: a patent review (2013 - present).Expert Opin Ther Pat. 2015 May;25(5):549-65. DM2CT4G RU https://www.ncbi.nlm.nih.gov/pubmed/25726713 DM2CT4G DI DM2CT4G DM2CT4G DN PMID25726713-Compound-49 DM2CT4G MI TTCJG29 DM2CT4G MN Serine/threonine-protein kinase mTOR (mTOR) DM2CT4G MT DTT DM2CT4G MA Inhibitor DM2CT4G RN Hedgehog inhibitors: a patent review (2013 - present).Expert Opin Ther Pat. 2015 May;25(5):549-65. DM2CT4G RU https://www.ncbi.nlm.nih.gov/pubmed/25726713 DM2CT4G DI DM2CT4G DM2CT4G DN PMID25726713-Compound-49 DM2CT4G MI TT8J1S3 DM2CT4G MN Smoothened homolog (SMO) DM2CT4G MT DTT DM2CT4G MA Inhibitor DM2CT4G RN Hedgehog inhibitors: a patent review (2013 - present).Expert Opin Ther Pat. 2015 May;25(5):549-65. DM2CT4G RU https://www.ncbi.nlm.nih.gov/pubmed/25726713 DM3BDFV DI DM3BDFV DM3BDFV DN PMID25726713-Compound-50 DM3BDFV MI TT0PG8F DM3BDFV MN Cyclin-dependent kinase 4 (CDK4) DM3BDFV MT DTT DM3BDFV MA Inhibitor DM3BDFV RN Hedgehog inhibitors: a patent review (2013 - present).Expert Opin Ther Pat. 2015 May;25(5):549-65. DM3BDFV RU https://www.ncbi.nlm.nih.gov/pubmed/25726713 DM3BDFV DI DM3BDFV DM3BDFV DN PMID25726713-Compound-50 DM3BDFV MI TTO0FDJ DM3BDFV MN Cyclin-dependent kinase 6 (CDK6) DM3BDFV MT DTT DM3BDFV MA Inhibitor DM3BDFV RN Hedgehog inhibitors: a patent review (2013 - present).Expert Opin Ther Pat. 2015 May;25(5):549-65. DM3BDFV RU https://www.ncbi.nlm.nih.gov/pubmed/25726713 DM3BDFV DI DM3BDFV DM3BDFV DN PMID25726713-Compound-50 DM3BDFV MI TTCJG29 DM3BDFV MN Serine/threonine-protein kinase mTOR (mTOR) DM3BDFV MT DTT DM3BDFV MA Inhibitor DM3BDFV RN Hedgehog inhibitors: a patent review (2013 - present).Expert Opin Ther Pat. 2015 May;25(5):549-65. DM3BDFV RU https://www.ncbi.nlm.nih.gov/pubmed/25726713 DM3BDFV DI DM3BDFV DM3BDFV DN PMID25726713-Compound-50 DM3BDFV MI TT8J1S3 DM3BDFV MN Smoothened homolog (SMO) DM3BDFV MT DTT DM3BDFV MA Inhibitor DM3BDFV RN Hedgehog inhibitors: a patent review (2013 - present).Expert Opin Ther Pat. 2015 May;25(5):549-65. DM3BDFV RU https://www.ncbi.nlm.nih.gov/pubmed/25726713 DMF0OW4 DI DMF0OW4 DMF0OW4 DN PMID25726713-Compound-51 DMF0OW4 MI TT0PG8F DMF0OW4 MN Cyclin-dependent kinase 4 (CDK4) DMF0OW4 MT DTT DMF0OW4 MA Inhibitor DMF0OW4 RN Hedgehog inhibitors: a patent review (2013 - present).Expert Opin Ther Pat. 2015 May;25(5):549-65. DMF0OW4 RU https://www.ncbi.nlm.nih.gov/pubmed/25726713 DMF0OW4 DI DMF0OW4 DMF0OW4 DN PMID25726713-Compound-51 DMF0OW4 MI TTO0FDJ DMF0OW4 MN Cyclin-dependent kinase 6 (CDK6) DMF0OW4 MT DTT DMF0OW4 MA Inhibitor DMF0OW4 RN Hedgehog inhibitors: a patent review (2013 - present).Expert Opin Ther Pat. 2015 May;25(5):549-65. DMF0OW4 RU https://www.ncbi.nlm.nih.gov/pubmed/25726713 DMF0OW4 DI DMF0OW4 DMF0OW4 DN PMID25726713-Compound-51 DMF0OW4 MI TTCJG29 DMF0OW4 MN Serine/threonine-protein kinase mTOR (mTOR) DMF0OW4 MT DTT DMF0OW4 MA Inhibitor DMF0OW4 RN Hedgehog inhibitors: a patent review (2013 - present).Expert Opin Ther Pat. 2015 May;25(5):549-65. DMF0OW4 RU https://www.ncbi.nlm.nih.gov/pubmed/25726713 DMF0OW4 DI DMF0OW4 DMF0OW4 DN PMID25726713-Compound-51 DMF0OW4 MI TT8J1S3 DMF0OW4 MN Smoothened homolog (SMO) DMF0OW4 MT DTT DMF0OW4 MA Inhibitor DMF0OW4 RN Hedgehog inhibitors: a patent review (2013 - present).Expert Opin Ther Pat. 2015 May;25(5):549-65. DMF0OW4 RU https://www.ncbi.nlm.nih.gov/pubmed/25726713 DMUHEP8 DI DMUHEP8 DMUHEP8 DN PMID25726713-Compound-56 DMUHEP8 MI TT8J1S3 DMUHEP8 MN Smoothened homolog (SMO) DMUHEP8 MT DTT DMUHEP8 MA Inhibitor DMUHEP8 RN Hedgehog inhibitors: a patent review (2013 - present).Expert Opin Ther Pat. 2015 May;25(5):549-65. DMUHEP8 RU https://www.ncbi.nlm.nih.gov/pubmed/25726713 DMMZHB1 DI DMMZHB1 DMMZHB1 DN PMID25726713-Compound-57 DMMZHB1 MI TT8J1S3 DMMZHB1 MN Smoothened homolog (SMO) DMMZHB1 MT DTT DMMZHB1 MA Inhibitor DMMZHB1 RN Hedgehog inhibitors: a patent review (2013 - present).Expert Opin Ther Pat. 2015 May;25(5):549-65. DMMZHB1 RU https://www.ncbi.nlm.nih.gov/pubmed/25726713 DMPDX3L DI DMPDX3L DMPDX3L DN PMID25726713-Compound-58 DMPDX3L MI TT8J1S3 DMPDX3L MN Smoothened homolog (SMO) DMPDX3L MT DTT DMPDX3L MA Inhibitor DMPDX3L RN Hedgehog inhibitors: a patent review (2013 - present).Expert Opin Ther Pat. 2015 May;25(5):549-65. DMPDX3L RU https://www.ncbi.nlm.nih.gov/pubmed/25726713 DMBF1OG DI DMBF1OG DMBF1OG DN PMID25726713-Compound-59 DMBF1OG MI TT8J1S3 DMBF1OG MN Smoothened homolog (SMO) DMBF1OG MT DTT DMBF1OG MA Inhibitor DMBF1OG RN Hedgehog inhibitors: a patent review (2013 - present).Expert Opin Ther Pat. 2015 May;25(5):549-65. DMBF1OG RU https://www.ncbi.nlm.nih.gov/pubmed/25726713 DMR8HSU DI DMR8HSU DMR8HSU DN PMID25726713-Compound-60 DMR8HSU MI TT8J1S3 DMR8HSU MN Smoothened homolog (SMO) DMR8HSU MT DTT DMR8HSU MA Inhibitor DMR8HSU RN Hedgehog inhibitors: a patent review (2013 - present).Expert Opin Ther Pat. 2015 May;25(5):549-65. DMR8HSU RU https://www.ncbi.nlm.nih.gov/pubmed/25726713 DMYXK7I DI DMYXK7I DMYXK7I DN PMID25726713-Compound-61 DMYXK7I MI TT8J1S3 DMYXK7I MN Smoothened homolog (SMO) DMYXK7I MT DTT DMYXK7I MA Inhibitor DMYXK7I RN Hedgehog inhibitors: a patent review (2013 - present).Expert Opin Ther Pat. 2015 May;25(5):549-65. DMYXK7I RU https://www.ncbi.nlm.nih.gov/pubmed/25726713 DMXNLTR DI DMXNLTR DMXNLTR DN PMID25726713-Compound-62 DMXNLTR MI TT8J1S3 DMXNLTR MN Smoothened homolog (SMO) DMXNLTR MT DTT DMXNLTR MA Inhibitor DMXNLTR RN Hedgehog inhibitors: a patent review (2013 - present).Expert Opin Ther Pat. 2015 May;25(5):549-65. DMXNLTR RU https://www.ncbi.nlm.nih.gov/pubmed/25726713 DMT0QLO DI DMT0QLO DMT0QLO DN PMID25726713-Compound-63 DMT0QLO MI TT8J1S3 DMT0QLO MN Smoothened homolog (SMO) DMT0QLO MT DTT DMT0QLO MA Inhibitor DMT0QLO RN Hedgehog inhibitors: a patent review (2013 - present).Expert Opin Ther Pat. 2015 May;25(5):549-65. DMT0QLO RU https://www.ncbi.nlm.nih.gov/pubmed/25726713 DM6A8TS DI DM6A8TS DM6A8TS DN PMID25726713-Compound-64 DM6A8TS MI TT8J1S3 DM6A8TS MN Smoothened homolog (SMO) DM6A8TS MT DTT DM6A8TS MA Inhibitor DM6A8TS RN Hedgehog inhibitors: a patent review (2013 - present).Expert Opin Ther Pat. 2015 May;25(5):549-65. DM6A8TS RU https://www.ncbi.nlm.nih.gov/pubmed/25726713 DM048C1 DI DM048C1 DM048C1 DN PMID25747044-Compound-miRNA DM048C1 MI TTLUW5B DM048C1 MN Laminin receptor 37/67kDa (LRP/LR) DM048C1 MT DTT DM048C1 MA Inhibitor DM048C1 RN Novel patented therapeutic approaches targeting the 37/67 kDa laminin receptor for treatment of cancer and Alzheimer's disease.Expert Opin Ther Pat. 2015 May;25(5):567-82. DM048C1 RU https://www.ncbi.nlm.nih.gov/pubmed/25747044 DMVWF6I DI DMVWF6I DMVWF6I DN PMID25772215-Compound-EP20082149552C9 DMVWF6I MI TT1ZAVI DMVWF6I MN Prostaglandin E2 receptor EP2 (PTGER2) DMVWF6I MT DTT DMVWF6I MA Antagonist DMVWF6I RN Evaluation of WO 2012/177618 A1 and US-2014/0179750 A1: novel small molecule antagonists of prostaglandin-E2 receptor EP2.Expert Opin Ther Pat. 2015 Jul;25(7):837-44. DMVWF6I RU https://www.ncbi.nlm.nih.gov/pubmed/25772215 DM48YKE DI DM48YKE DM48YKE DN PMID25772215-Compound-EP2149552diaminopyrimidines DM48YKE MI TT1ZAVI DM48YKE MN Prostaglandin E2 receptor EP2 (PTGER2) DM48YKE MT DTT DM48YKE MA Antagonist DM48YKE RN Evaluation of WO 2012/177618 A1 and US-2014/0179750 A1: novel small molecule antagonists of prostaglandin-E2 receptor EP2.Expert Opin Ther Pat. 2015 Jul;25(7):837-44. DM48YKE RU https://www.ncbi.nlm.nih.gov/pubmed/25772215 DM7EKZ6 DI DM7EKZ6 DM7EKZ6 DN PMID25772215-Compound-US02014179750M1 DM7EKZ6 MI TT1ZAVI DM7EKZ6 MN Prostaglandin E2 receptor EP2 (PTGER2) DM7EKZ6 MT DTT DM7EKZ6 MA Antagonist DM7EKZ6 RN Evaluation of WO 2012/177618 A1 and US-2014/0179750 A1: novel small molecule antagonists of prostaglandin-E2 receptor EP2.Expert Opin Ther Pat. 2015 Jul;25(7):837-44. DM7EKZ6 RU https://www.ncbi.nlm.nih.gov/pubmed/25772215 DMC50F3 DI DMC50F3 DMC50F3 DN PMID25772215-Compound-US02014179750M2 DMC50F3 MI TT1ZAVI DMC50F3 MN Prostaglandin E2 receptor EP2 (PTGER2) DMC50F3 MT DTT DMC50F3 MA Antagonist DMC50F3 RN Evaluation of WO 2012/177618 A1 and US-2014/0179750 A1: novel small molecule antagonists of prostaglandin-E2 receptor EP2.Expert Opin Ther Pat. 2015 Jul;25(7):837-44. DMC50F3 RU https://www.ncbi.nlm.nih.gov/pubmed/25772215 DMJA1XC DI DMJA1XC DMJA1XC DN PMID25772215-Compound-US02014179750M3 DMJA1XC MI TT1ZAVI DMJA1XC MN Prostaglandin E2 receptor EP2 (PTGER2) DMJA1XC MT DTT DMJA1XC MA Antagonist DMJA1XC RN Evaluation of WO 2012/177618 A1 and US-2014/0179750 A1: novel small molecule antagonists of prostaglandin-E2 receptor EP2.Expert Opin Ther Pat. 2015 Jul;25(7):837-44. DMJA1XC RU https://www.ncbi.nlm.nih.gov/pubmed/25772215 DMWD1FP DI DMWD1FP DMWD1FP DN PMID25772215-Compound-US02014179750TG6-10-1 DMWD1FP MI TT1ZAVI DMWD1FP MN Prostaglandin E2 receptor EP2 (PTGER2) DMWD1FP MT DTT DMWD1FP MA Antagonist DMWD1FP RN Evaluation of WO 2012/177618 A1 and US-2014/0179750 A1: novel small molecule antagonists of prostaglandin-E2 receptor EP2.Expert Opin Ther Pat. 2015 Jul;25(7):837-44. DMWD1FP RU https://www.ncbi.nlm.nih.gov/pubmed/25772215 DMRLZD2 DI DMRLZD2 DMRLZD2 DN PMID25772215-Compound-US02014179750TG6-129 DMRLZD2 MI TT1ZAVI DMRLZD2 MN Prostaglandin E2 receptor EP2 (PTGER2) DMRLZD2 MT DTT DMRLZD2 MA Antagonist DMRLZD2 RN Evaluation of WO 2012/177618 A1 and US-2014/0179750 A1: novel small molecule antagonists of prostaglandin-E2 receptor EP2.Expert Opin Ther Pat. 2015 Jul;25(7):837-44. DMRLZD2 RU https://www.ncbi.nlm.nih.gov/pubmed/25772215 DMB87WZ DI DMB87WZ DMB87WZ DN PMID25772215-Compound-US02014179750TG7-112-2 DMB87WZ MI TT1ZAVI DMB87WZ MN Prostaglandin E2 receptor EP2 (PTGER2) DMB87WZ MT DTT DMB87WZ MA Antagonist DMB87WZ RN Evaluation of WO 2012/177618 A1 and US-2014/0179750 A1: novel small molecule antagonists of prostaglandin-E2 receptor EP2.Expert Opin Ther Pat. 2015 Jul;25(7):837-44. DMB87WZ RU https://www.ncbi.nlm.nih.gov/pubmed/25772215 DMORK8H DI DMORK8H DMORK8H DN PMID25772215-Compound-US02014179750TG7-170 DMORK8H MI TT1ZAVI DMORK8H MN Prostaglandin E2 receptor EP2 (PTGER2) DMORK8H MT DTT DMORK8H MA Antagonist DMORK8H RN Evaluation of WO 2012/177618 A1 and US-2014/0179750 A1: novel small molecule antagonists of prostaglandin-E2 receptor EP2.Expert Opin Ther Pat. 2015 Jul;25(7):837-44. DMORK8H RU https://www.ncbi.nlm.nih.gov/pubmed/25772215 DM9I4EV DI DM9I4EV DM9I4EV DN PMID25772215-Compound-US02014179750TG7-74 DM9I4EV MI TT1ZAVI DM9I4EV MN Prostaglandin E2 receptor EP2 (PTGER2) DM9I4EV MT DTT DM9I4EV MA Antagonist DM9I4EV RN Evaluation of WO 2012/177618 A1 and US-2014/0179750 A1: novel small molecule antagonists of prostaglandin-E2 receptor EP2.Expert Opin Ther Pat. 2015 Jul;25(7):837-44. DM9I4EV RU https://www.ncbi.nlm.nih.gov/pubmed/25772215 DMRTZC4 DI DMRTZC4 DMRTZC4 DN PMID25772215-Compound-US02014179750TG7-76 DMRTZC4 MI TT1ZAVI DMRTZC4 MN Prostaglandin E2 receptor EP2 (PTGER2) DMRTZC4 MT DTT DMRTZC4 MA Antagonist DMRTZC4 RN Evaluation of WO 2012/177618 A1 and US-2014/0179750 A1: novel small molecule antagonists of prostaglandin-E2 receptor EP2.Expert Opin Ther Pat. 2015 Jul;25(7):837-44. DMRTZC4 RU https://www.ncbi.nlm.nih.gov/pubmed/25772215 DM8IL6Y DI DM8IL6Y DM8IL6Y DN PMID25772215-Compound-US02014179750TG8-15 DM8IL6Y MI TT1ZAVI DM8IL6Y MN Prostaglandin E2 receptor EP2 (PTGER2) DM8IL6Y MT DTT DM8IL6Y MA Antagonist DM8IL6Y RN Evaluation of WO 2012/177618 A1 and US-2014/0179750 A1: novel small molecule antagonists of prostaglandin-E2 receptor EP2.Expert Opin Ther Pat. 2015 Jul;25(7):837-44. DM8IL6Y RU https://www.ncbi.nlm.nih.gov/pubmed/25772215 DMD3CB4 DI DMD3CB4 DMD3CB4 DN PMID25772215-Compound-WO2012177618M4 DMD3CB4 MI TT1ZAVI DMD3CB4 MN Prostaglandin E2 receptor EP2 (PTGER2) DMD3CB4 MT DTT DMD3CB4 MA Antagonist DMD3CB4 RN Evaluation of WO 2012/177618 A1 and US-2014/0179750 A1: novel small molecule antagonists of prostaglandin-E2 receptor EP2.Expert Opin Ther Pat. 2015 Jul;25(7):837-44. DMD3CB4 RU https://www.ncbi.nlm.nih.gov/pubmed/25772215 DMWUK9X DI DMWUK9X DMWUK9X DN PMID25772215-Compound-WO2012177618M5 DMWUK9X MI TT1ZAVI DMWUK9X MN Prostaglandin E2 receptor EP2 (PTGER2) DMWUK9X MT DTT DMWUK9X MA Antagonist DMWUK9X RN Evaluation of WO 2012/177618 A1 and US-2014/0179750 A1: novel small molecule antagonists of prostaglandin-E2 receptor EP2.Expert Opin Ther Pat. 2015 Jul;25(7):837-44. DMWUK9X RU https://www.ncbi.nlm.nih.gov/pubmed/25772215 DMDCZVI DI DMDCZVI DMDCZVI DN PMID25772215-Compound-WO2012177618M6 DMDCZVI MI TT1ZAVI DMDCZVI MN Prostaglandin E2 receptor EP2 (PTGER2) DMDCZVI MT DTT DMDCZVI MA Antagonist DMDCZVI RN Evaluation of WO 2012/177618 A1 and US-2014/0179750 A1: novel small molecule antagonists of prostaglandin-E2 receptor EP2.Expert Opin Ther Pat. 2015 Jul;25(7):837-44. DMDCZVI RU https://www.ncbi.nlm.nih.gov/pubmed/25772215 DMGHSR9 DI DMGHSR9 DMGHSR9 DN PMID25776143-Compound-1 DMGHSR9 MI TT4TFGN DMGHSR9 MN Vasopressin V1a receptor (V1AR) DMGHSR9 MT DTT DMGHSR9 MA Agonist DMGHSR9 RN Vasopressin V1a and V1b receptor modulators: a patent review (2012 - 2014).Expert Opin Ther Pat. 2015 Jun;25(6):711-22. DMGHSR9 RU https://www.ncbi.nlm.nih.gov/pubmed/25776143 DMTZRFP DI DMTZRFP DMTZRFP DN PMID25776143-Compound-2 DMTZRFP MI TT4TFGN DMTZRFP MN Vasopressin V1a receptor (V1AR) DMTZRFP MT DTT DMTZRFP MA Agonist DMTZRFP RN Vasopressin V1a and V1b receptor modulators: a patent review (2012 - 2014).Expert Opin Ther Pat. 2015 Jun;25(6):711-22. DMTZRFP RU https://www.ncbi.nlm.nih.gov/pubmed/25776143 DMCULI1 DI DMCULI1 DMCULI1 DN PMID25776143-Compound-3 DMCULI1 MI TT4TFGN DMCULI1 MN Vasopressin V1a receptor (V1AR) DMCULI1 MT DTT DMCULI1 MA Inhibitor DMCULI1 RN Vasopressin V1a and V1b receptor modulators: a patent review (2012 - 2014).Expert Opin Ther Pat. 2015 Jun;25(6):711-22. DMCULI1 RU https://www.ncbi.nlm.nih.gov/pubmed/25776143 DMMVETJ DI DMMVETJ DMMVETJ DN PMID25776143-Compound-4 DMMVETJ MI TT4TFGN DMMVETJ MN Vasopressin V1a receptor (V1AR) DMMVETJ MT DTT DMMVETJ MA Inhibitor DMMVETJ RN Vasopressin V1a and V1b receptor modulators: a patent review (2012 - 2014).Expert Opin Ther Pat. 2015 Jun;25(6):711-22. DMMVETJ RU https://www.ncbi.nlm.nih.gov/pubmed/25776143 DM7QIMN DI DM7QIMN DM7QIMN DN PMID25776143-Compound-7 DM7QIMN MI TT4TFGN DM7QIMN MN Vasopressin V1a receptor (V1AR) DM7QIMN MT DTT DM7QIMN MA Antagonist DM7QIMN RN Vasopressin V1a and V1b receptor modulators: a patent review (2012 - 2014).Expert Opin Ther Pat. 2015 Jun;25(6):711-22. DM7QIMN RU https://www.ncbi.nlm.nih.gov/pubmed/25776143 DMUKFJ0 DI DMUKFJ0 DMUKFJ0 DN PMID25776143-Compound-8 DMUKFJ0 MI TT4TFGN DMUKFJ0 MN Vasopressin V1a receptor (V1AR) DMUKFJ0 MT DTT DMUKFJ0 MA Antagonist DMUKFJ0 RN Vasopressin V1a and V1b receptor modulators: a patent review (2012 - 2014).Expert Opin Ther Pat. 2015 Jun;25(6):711-22. DMUKFJ0 RU https://www.ncbi.nlm.nih.gov/pubmed/25776143 DMEC1TR DI DMEC1TR DMEC1TR DN PMID25828189-Compound-19 DMEC1TR MI TT9O6WS DMEC1TR MN Glucagon receptor (GCGR) DMEC1TR MT DTT DMEC1TR MA Antagonist DMEC1TR RN Small molecule glucagon receptor antagonists: a patent review (2011 - 2014).Expert Opin Ther Pat. 2015 Jul;25(7):819-30. DMEC1TR RU https://www.ncbi.nlm.nih.gov/pubmed/25828189 DM7D0CT DI DM7D0CT DM7D0CT DN PMID25828189-Compound-21 DM7D0CT MI TT9O6WS DM7D0CT MN Glucagon receptor (GCGR) DM7D0CT MT DTT DM7D0CT MA Antagonist DM7D0CT RN Small molecule glucagon receptor antagonists: a patent review (2011 - 2014).Expert Opin Ther Pat. 2015 Jul;25(7):819-30. DM7D0CT RU https://www.ncbi.nlm.nih.gov/pubmed/25828189 DMC2O0Q DI DMC2O0Q DMC2O0Q DN PMID25828189-Compound-22 DMC2O0Q MI TT9O6WS DMC2O0Q MN Glucagon receptor (GCGR) DMC2O0Q MT DTT DMC2O0Q MA Antagonist DMC2O0Q RN Small molecule glucagon receptor antagonists: a patent review (2011 - 2014).Expert Opin Ther Pat. 2015 Jul;25(7):819-30. DMC2O0Q RU https://www.ncbi.nlm.nih.gov/pubmed/25828189 DMYPT2H DI DMYPT2H DMYPT2H DN PMID25980951-Compound-1 DMYPT2H MI TTQ5LRD DMYPT2H MN Cellular inhibitor of apoptosis 1 (BIRC2) DMYPT2H MT DTT DMYPT2H MA Antagonist DMYPT2H RN Small molecule inhibitor of apoptosis proteins antagonists: a patent review.Expert Opin Ther Pat. 2015 Jul;25(7):755-74. DMYPT2H RU https://www.ncbi.nlm.nih.gov/pubmed/25980951 DMYPT2H DI DMYPT2H DMYPT2H DN PMID25980951-Compound-1 DMYPT2H MI TTIRY6K DMYPT2H MN Cellular inhibitor of apoptosis 2 (BIRC3) DMYPT2H MT DTT DMYPT2H MA Antagonist DMYPT2H RN Small molecule inhibitor of apoptosis proteins antagonists: a patent review.Expert Opin Ther Pat. 2015 Jul;25(7):755-74. DMYPT2H RU https://www.ncbi.nlm.nih.gov/pubmed/25980951 DMYPT2H DI DMYPT2H DMYPT2H DN PMID25980951-Compound-1 DMYPT2H MI TTR7B60 DMYPT2H MN X-linked inhibitor of apoptosis protein (XIAP) DMYPT2H MT DTT DMYPT2H MA Antagonist DMYPT2H RN Small molecule inhibitor of apoptosis proteins antagonists: a patent review.Expert Opin Ther Pat. 2015 Jul;25(7):755-74. DMYPT2H RU https://www.ncbi.nlm.nih.gov/pubmed/25980951 DME3ZJO DI DME3ZJO DME3ZJO DN PMID25980951-Compound-10 DME3ZJO MI TTR7B60 DME3ZJO MN X-linked inhibitor of apoptosis protein (XIAP) DME3ZJO MT DTT DME3ZJO MA Antagonist DME3ZJO RN Small molecule inhibitor of apoptosis proteins antagonists: a patent review.Expert Opin Ther Pat. 2015 Jul;25(7):755-74. DME3ZJO RU https://www.ncbi.nlm.nih.gov/pubmed/25980951 DMZ9LSY DI DMZ9LSY DMZ9LSY DN PMID25980951-Compound-11 DMZ9LSY MI TTR7B60 DMZ9LSY MN X-linked inhibitor of apoptosis protein (XIAP) DMZ9LSY MT DTT DMZ9LSY MA Antagonist DMZ9LSY RN Small molecule inhibitor of apoptosis proteins antagonists: a patent review.Expert Opin Ther Pat. 2015 Jul;25(7):755-74. DMZ9LSY RU https://www.ncbi.nlm.nih.gov/pubmed/25980951 DMG8K1P DI DMG8K1P DMG8K1P DN PMID25980951-Compound-12 DMG8K1P MI TTR7B60 DMG8K1P MN X-linked inhibitor of apoptosis protein (XIAP) DMG8K1P MT DTT DMG8K1P MA Antagonist DMG8K1P RN Small molecule inhibitor of apoptosis proteins antagonists: a patent review.Expert Opin Ther Pat. 2015 Jul;25(7):755-74. DMG8K1P RU https://www.ncbi.nlm.nih.gov/pubmed/25980951 DMGHR4D DI DMGHR4D DMGHR4D DN PMID25980951-Compound-13 DMGHR4D MI TTR7B60 DMGHR4D MN X-linked inhibitor of apoptosis protein (XIAP) DMGHR4D MT DTT DMGHR4D MA Antagonist DMGHR4D RN Small molecule inhibitor of apoptosis proteins antagonists: a patent review.Expert Opin Ther Pat. 2015 Jul;25(7):755-74. DMGHR4D RU https://www.ncbi.nlm.nih.gov/pubmed/25980951 DM637IC DI DM637IC DM637IC DN PMID25980951-Compound-14 DM637IC MI TTR7B60 DM637IC MN X-linked inhibitor of apoptosis protein (XIAP) DM637IC MT DTT DM637IC MA Antagonist DM637IC RN Small molecule inhibitor of apoptosis proteins antagonists: a patent review.Expert Opin Ther Pat. 2015 Jul;25(7):755-74. DM637IC RU https://www.ncbi.nlm.nih.gov/pubmed/25980951 DMB2MIT DI DMB2MIT DMB2MIT DN PMID25980951-Compound-15 DMB2MIT MI TTR7B60 DMB2MIT MN X-linked inhibitor of apoptosis protein (XIAP) DMB2MIT MT DTT DMB2MIT MA Antagonist DMB2MIT RN Small molecule inhibitor of apoptosis proteins antagonists: a patent review.Expert Opin Ther Pat. 2015 Jul;25(7):755-74. DMB2MIT RU https://www.ncbi.nlm.nih.gov/pubmed/25980951 DM1J3LE DI DM1J3LE DM1J3LE DN PMID25980951-Compound-16 DM1J3LE MI TTQ5LRD DM1J3LE MN Cellular inhibitor of apoptosis 1 (BIRC2) DM1J3LE MT DTT DM1J3LE MA Antagonist DM1J3LE RN Small molecule inhibitor of apoptosis proteins antagonists: a patent review.Expert Opin Ther Pat. 2015 Jul;25(7):755-74. DM1J3LE RU https://www.ncbi.nlm.nih.gov/pubmed/25980951 DMSC8B6 DI DMSC8B6 DMSC8B6 DN PMID25980951-Compound-17 DMSC8B6 MI TTQ5LRD DMSC8B6 MN Cellular inhibitor of apoptosis 1 (BIRC2) DMSC8B6 MT DTT DMSC8B6 MA Antagonist DMSC8B6 RN Small molecule inhibitor of apoptosis proteins antagonists: a patent review.Expert Opin Ther Pat. 2015 Jul;25(7):755-74. DMSC8B6 RU https://www.ncbi.nlm.nih.gov/pubmed/25980951 DMC3NHJ DI DMC3NHJ DMC3NHJ DN PMID25980951-Compound-18 DMC3NHJ MI TTQ5LRD DMC3NHJ MN Cellular inhibitor of apoptosis 1 (BIRC2) DMC3NHJ MT DTT DMC3NHJ MA Antagonist DMC3NHJ RN Small molecule inhibitor of apoptosis proteins antagonists: a patent review.Expert Opin Ther Pat. 2015 Jul;25(7):755-74. DMC3NHJ RU https://www.ncbi.nlm.nih.gov/pubmed/25980951 DMGIV0M DI DMGIV0M DMGIV0M DN PMID25980951-Compound-19 DMGIV0M MI TTQ5LRD DMGIV0M MN Cellular inhibitor of apoptosis 1 (BIRC2) DMGIV0M MT DTT DMGIV0M MA Antagonist DMGIV0M RN Small molecule inhibitor of apoptosis proteins antagonists: a patent review.Expert Opin Ther Pat. 2015 Jul;25(7):755-74. DMGIV0M RU https://www.ncbi.nlm.nih.gov/pubmed/25980951 DMGIV0M DI DMGIV0M DMGIV0M DN PMID25980951-Compound-19 DMGIV0M MI TTR7B60 DMGIV0M MN X-linked inhibitor of apoptosis protein (XIAP) DMGIV0M MT DTT DMGIV0M MA Antagonist DMGIV0M RN Small molecule inhibitor of apoptosis proteins antagonists: a patent review.Expert Opin Ther Pat. 2015 Jul;25(7):755-74. DMGIV0M RU https://www.ncbi.nlm.nih.gov/pubmed/25980951 DMM45AC DI DMM45AC DMM45AC DN PMID25980951-Compound-20 DMM45AC MI TTQ5LRD DMM45AC MN Cellular inhibitor of apoptosis 1 (BIRC2) DMM45AC MT DTT DMM45AC MA Antagonist DMM45AC RN Small molecule inhibitor of apoptosis proteins antagonists: a patent review.Expert Opin Ther Pat. 2015 Jul;25(7):755-74. DMM45AC RU https://www.ncbi.nlm.nih.gov/pubmed/25980951 DMM45AC DI DMM45AC DMM45AC DN PMID25980951-Compound-20 DMM45AC MI TTR7B60 DMM45AC MN X-linked inhibitor of apoptosis protein (XIAP) DMM45AC MT DTT DMM45AC MA Antagonist DMM45AC RN Small molecule inhibitor of apoptosis proteins antagonists: a patent review.Expert Opin Ther Pat. 2015 Jul;25(7):755-74. DMM45AC RU https://www.ncbi.nlm.nih.gov/pubmed/25980951 DMIE0MR DI DMIE0MR DMIE0MR DN PMID25980951-Compound-21 DMIE0MR MI TTQ5LRD DMIE0MR MN Cellular inhibitor of apoptosis 1 (BIRC2) DMIE0MR MT DTT DMIE0MR MA Antagonist DMIE0MR RN Small molecule inhibitor of apoptosis proteins antagonists: a patent review.Expert Opin Ther Pat. 2015 Jul;25(7):755-74. DMIE0MR RU https://www.ncbi.nlm.nih.gov/pubmed/25980951 DMIE0MR DI DMIE0MR DMIE0MR DN PMID25980951-Compound-21 DMIE0MR MI TTR7B60 DMIE0MR MN X-linked inhibitor of apoptosis protein (XIAP) DMIE0MR MT DTT DMIE0MR MA Antagonist DMIE0MR RN Small molecule inhibitor of apoptosis proteins antagonists: a patent review.Expert Opin Ther Pat. 2015 Jul;25(7):755-74. DMIE0MR RU https://www.ncbi.nlm.nih.gov/pubmed/25980951 DM6OEHK DI DM6OEHK DM6OEHK DN PMID25980951-Compound-22 DM6OEHK MI TTQ5LRD DM6OEHK MN Cellular inhibitor of apoptosis 1 (BIRC2) DM6OEHK MT DTT DM6OEHK MA Antagonist DM6OEHK RN Small molecule inhibitor of apoptosis proteins antagonists: a patent review.Expert Opin Ther Pat. 2015 Jul;25(7):755-74. DM6OEHK RU https://www.ncbi.nlm.nih.gov/pubmed/25980951 DM6OEHK DI DM6OEHK DM6OEHK DN PMID25980951-Compound-22 DM6OEHK MI TTR7B60 DM6OEHK MN X-linked inhibitor of apoptosis protein (XIAP) DM6OEHK MT DTT DM6OEHK MA Antagonist DM6OEHK RN Small molecule inhibitor of apoptosis proteins antagonists: a patent review.Expert Opin Ther Pat. 2015 Jul;25(7):755-74. DM6OEHK RU https://www.ncbi.nlm.nih.gov/pubmed/25980951 DMK9DH7 DI DMK9DH7 DMK9DH7 DN PMID25980951-Compound-26 DMK9DH7 MI TTR7B60 DMK9DH7 MN X-linked inhibitor of apoptosis protein (XIAP) DMK9DH7 MT DTT DMK9DH7 MA Antagonist DMK9DH7 RN Small molecule inhibitor of apoptosis proteins antagonists: a patent review.Expert Opin Ther Pat. 2015 Jul;25(7):755-74. DMK9DH7 RU https://www.ncbi.nlm.nih.gov/pubmed/25980951 DMXAH9F DI DMXAH9F DMXAH9F DN PMID25980951-Compound-27 DMXAH9F MI TTQ5LRD DMXAH9F MN Cellular inhibitor of apoptosis 1 (BIRC2) DMXAH9F MT DTT DMXAH9F MA Antagonist DMXAH9F RN Small molecule inhibitor of apoptosis proteins antagonists: a patent review.Expert Opin Ther Pat. 2015 Jul;25(7):755-74. DMXAH9F RU https://www.ncbi.nlm.nih.gov/pubmed/25980951 DMXAH9F DI DMXAH9F DMXAH9F DN PMID25980951-Compound-27 DMXAH9F MI TTIRY6K DMXAH9F MN Cellular inhibitor of apoptosis 2 (BIRC3) DMXAH9F MT DTT DMXAH9F MA Antagonist DMXAH9F RN Small molecule inhibitor of apoptosis proteins antagonists: a patent review.Expert Opin Ther Pat. 2015 Jul;25(7):755-74. DMXAH9F RU https://www.ncbi.nlm.nih.gov/pubmed/25980951 DMXAH9F DI DMXAH9F DMXAH9F DN PMID25980951-Compound-27 DMXAH9F MI TTR7B60 DMXAH9F MN X-linked inhibitor of apoptosis protein (XIAP) DMXAH9F MT DTT DMXAH9F MA Antagonist DMXAH9F RN Small molecule inhibitor of apoptosis proteins antagonists: a patent review.Expert Opin Ther Pat. 2015 Jul;25(7):755-74. DMXAH9F RU https://www.ncbi.nlm.nih.gov/pubmed/25980951 DMV0EIA DI DMV0EIA DMV0EIA DN PMID25980951-Compound-28 DMV0EIA MI TTR7B60 DMV0EIA MN X-linked inhibitor of apoptosis protein (XIAP) DMV0EIA MT DTT DMV0EIA MA Antagonist DMV0EIA RN Small molecule inhibitor of apoptosis proteins antagonists: a patent review.Expert Opin Ther Pat. 2015 Jul;25(7):755-74. DMV0EIA RU https://www.ncbi.nlm.nih.gov/pubmed/25980951 DM5WIX3 DI DM5WIX3 DM5WIX3 DN PMID25980951-Compound-29 DM5WIX3 MI TTR7B60 DM5WIX3 MN X-linked inhibitor of apoptosis protein (XIAP) DM5WIX3 MT DTT DM5WIX3 MA Antagonist DM5WIX3 RN Small molecule inhibitor of apoptosis proteins antagonists: a patent review.Expert Opin Ther Pat. 2015 Jul;25(7):755-74. DM5WIX3 RU https://www.ncbi.nlm.nih.gov/pubmed/25980951 DMPSWXU DI DMPSWXU DMPSWXU DN PMID25980951-Compound-3 DMPSWXU MI TTQ5LRD DMPSWXU MN Cellular inhibitor of apoptosis 1 (BIRC2) DMPSWXU MT DTT DMPSWXU MA Antagonist DMPSWXU RN Small molecule inhibitor of apoptosis proteins antagonists: a patent review.Expert Opin Ther Pat. 2015 Jul;25(7):755-74. DMPSWXU RU https://www.ncbi.nlm.nih.gov/pubmed/25980951 DMPSWXU DI DMPSWXU DMPSWXU DN PMID25980951-Compound-3 DMPSWXU MI TTR7B60 DMPSWXU MN X-linked inhibitor of apoptosis protein (XIAP) DMPSWXU MT DTT DMPSWXU MA Antagonist DMPSWXU RN Small molecule inhibitor of apoptosis proteins antagonists: a patent review.Expert Opin Ther Pat. 2015 Jul;25(7):755-74. DMPSWXU RU https://www.ncbi.nlm.nih.gov/pubmed/25980951 DMXCSHE DI DMXCSHE DMXCSHE DN PMID25980951-Compound-30 DMXCSHE MI TTR7B60 DMXCSHE MN X-linked inhibitor of apoptosis protein (XIAP) DMXCSHE MT DTT DMXCSHE MA Antagonist DMXCSHE RN Small molecule inhibitor of apoptosis proteins antagonists: a patent review.Expert Opin Ther Pat. 2015 Jul;25(7):755-74. DMXCSHE RU https://www.ncbi.nlm.nih.gov/pubmed/25980951 DMC1Y2T DI DMC1Y2T DMC1Y2T DN PMID25980951-Compound-31 DMC1Y2T MI TTR7B60 DMC1Y2T MN X-linked inhibitor of apoptosis protein (XIAP) DMC1Y2T MT DTT DMC1Y2T MA Antagonist DMC1Y2T RN Small molecule inhibitor of apoptosis proteins antagonists: a patent review.Expert Opin Ther Pat. 2015 Jul;25(7):755-74. DMC1Y2T RU https://www.ncbi.nlm.nih.gov/pubmed/25980951 DMXETA8 DI DMXETA8 DMXETA8 DN PMID25980951-Compound-32 DMXETA8 MI TTR7B60 DMXETA8 MN X-linked inhibitor of apoptosis protein (XIAP) DMXETA8 MT DTT DMXETA8 MA Antagonist DMXETA8 RN Small molecule inhibitor of apoptosis proteins antagonists: a patent review.Expert Opin Ther Pat. 2015 Jul;25(7):755-74. DMXETA8 RU https://www.ncbi.nlm.nih.gov/pubmed/25980951 DMYO9UD DI DMYO9UD DMYO9UD DN PMID25980951-Compound-33 DMYO9UD MI TTR7B60 DMYO9UD MN X-linked inhibitor of apoptosis protein (XIAP) DMYO9UD MT DTT DMYO9UD MA Antagonist DMYO9UD RN Small molecule inhibitor of apoptosis proteins antagonists: a patent review.Expert Opin Ther Pat. 2015 Jul;25(7):755-74. DMYO9UD RU https://www.ncbi.nlm.nih.gov/pubmed/25980951 DMBD4K9 DI DMBD4K9 DMBD4K9 DN PMID25980951-Compound-36 DMBD4K9 MI TTQ5LRD DMBD4K9 MN Cellular inhibitor of apoptosis 1 (BIRC2) DMBD4K9 MT DTT DMBD4K9 MA Antagonist DMBD4K9 RN Small molecule inhibitor of apoptosis proteins antagonists: a patent review.Expert Opin Ther Pat. 2015 Jul;25(7):755-74. DMBD4K9 RU https://www.ncbi.nlm.nih.gov/pubmed/25980951 DMBD4K9 DI DMBD4K9 DMBD4K9 DN PMID25980951-Compound-36 DMBD4K9 MI TTR7B60 DMBD4K9 MN X-linked inhibitor of apoptosis protein (XIAP) DMBD4K9 MT DTT DMBD4K9 MA Antagonist DMBD4K9 RN Small molecule inhibitor of apoptosis proteins antagonists: a patent review.Expert Opin Ther Pat. 2015 Jul;25(7):755-74. DMBD4K9 RU https://www.ncbi.nlm.nih.gov/pubmed/25980951 DMHP6J2 DI DMHP6J2 DMHP6J2 DN PMID25980951-Compound-37 DMHP6J2 MI TTQ5LRD DMHP6J2 MN Cellular inhibitor of apoptosis 1 (BIRC2) DMHP6J2 MT DTT DMHP6J2 MA Antagonist DMHP6J2 RN Small molecule inhibitor of apoptosis proteins antagonists: a patent review.Expert Opin Ther Pat. 2015 Jul;25(7):755-74. DMHP6J2 RU https://www.ncbi.nlm.nih.gov/pubmed/25980951 DMHP6J2 DI DMHP6J2 DMHP6J2 DN PMID25980951-Compound-37 DMHP6J2 MI TTR7B60 DMHP6J2 MN X-linked inhibitor of apoptosis protein (XIAP) DMHP6J2 MT DTT DMHP6J2 MA Antagonist DMHP6J2 RN Small molecule inhibitor of apoptosis proteins antagonists: a patent review.Expert Opin Ther Pat. 2015 Jul;25(7):755-74. DMHP6J2 RU https://www.ncbi.nlm.nih.gov/pubmed/25980951 DMEUBDA DI DMEUBDA DMEUBDA DN PMID25980951-Compound-38 DMEUBDA MI TTQ5LRD DMEUBDA MN Cellular inhibitor of apoptosis 1 (BIRC2) DMEUBDA MT DTT DMEUBDA MA Antagonist DMEUBDA RN Small molecule inhibitor of apoptosis proteins antagonists: a patent review.Expert Opin Ther Pat. 2015 Jul;25(7):755-74. DMEUBDA RU https://www.ncbi.nlm.nih.gov/pubmed/25980951 DMEUBDA DI DMEUBDA DMEUBDA DN PMID25980951-Compound-38 DMEUBDA MI TTR7B60 DMEUBDA MN X-linked inhibitor of apoptosis protein (XIAP) DMEUBDA MT DTT DMEUBDA MA Antagonist DMEUBDA RN Small molecule inhibitor of apoptosis proteins antagonists: a patent review.Expert Opin Ther Pat. 2015 Jul;25(7):755-74. DMEUBDA RU https://www.ncbi.nlm.nih.gov/pubmed/25980951 DMEZ3QV DI DMEZ3QV DMEZ3QV DN PMID25980951-Compound-39 DMEZ3QV MI TTR7B60 DMEZ3QV MN X-linked inhibitor of apoptosis protein (XIAP) DMEZ3QV MT DTT DMEZ3QV MA Antagonist DMEZ3QV RN Small molecule inhibitor of apoptosis proteins antagonists: a patent review.Expert Opin Ther Pat. 2015 Jul;25(7):755-74. DMEZ3QV RU https://www.ncbi.nlm.nih.gov/pubmed/25980951 DM9RZSH DI DM9RZSH DM9RZSH DN PMID25980951-Compound-4 DM9RZSH MI TTQ5LRD DM9RZSH MN Cellular inhibitor of apoptosis 1 (BIRC2) DM9RZSH MT DTT DM9RZSH MA Antagonist DM9RZSH RN Small molecule inhibitor of apoptosis proteins antagonists: a patent review.Expert Opin Ther Pat. 2015 Jul;25(7):755-74. DM9RZSH RU https://www.ncbi.nlm.nih.gov/pubmed/25980951 DM9RZSH DI DM9RZSH DM9RZSH DN PMID25980951-Compound-4 DM9RZSH MI TTR7B60 DM9RZSH MN X-linked inhibitor of apoptosis protein (XIAP) DM9RZSH MT DTT DM9RZSH MA Antagonist DM9RZSH RN Small molecule inhibitor of apoptosis proteins antagonists: a patent review.Expert Opin Ther Pat. 2015 Jul;25(7):755-74. DM9RZSH RU https://www.ncbi.nlm.nih.gov/pubmed/25980951 DMJOD8I DI DMJOD8I DMJOD8I DN PMID25980951-Compound-40 DMJOD8I MI TTR7B60 DMJOD8I MN X-linked inhibitor of apoptosis protein (XIAP) DMJOD8I MT DTT DMJOD8I MA Antagonist DMJOD8I RN Small molecule inhibitor of apoptosis proteins antagonists: a patent review.Expert Opin Ther Pat. 2015 Jul;25(7):755-74. DMJOD8I RU https://www.ncbi.nlm.nih.gov/pubmed/25980951 DMNROIP DI DMNROIP DMNROIP DN PMID25980951-Compound-41 DMNROIP MI TTQ5LRD DMNROIP MN Cellular inhibitor of apoptosis 1 (BIRC2) DMNROIP MT DTT DMNROIP MA Antagonist DMNROIP RN Small molecule inhibitor of apoptosis proteins antagonists: a patent review.Expert Opin Ther Pat. 2015 Jul;25(7):755-74. DMNROIP RU https://www.ncbi.nlm.nih.gov/pubmed/25980951 DMNROIP DI DMNROIP DMNROIP DN PMID25980951-Compound-41 DMNROIP MI TTR7B60 DMNROIP MN X-linked inhibitor of apoptosis protein (XIAP) DMNROIP MT DTT DMNROIP MA Antagonist DMNROIP RN Small molecule inhibitor of apoptosis proteins antagonists: a patent review.Expert Opin Ther Pat. 2015 Jul;25(7):755-74. DMNROIP RU https://www.ncbi.nlm.nih.gov/pubmed/25980951 DM8XESD DI DM8XESD DM8XESD DN PMID25980951-Compound-42 DM8XESD MI TTQ5LRD DM8XESD MN Cellular inhibitor of apoptosis 1 (BIRC2) DM8XESD MT DTT DM8XESD MA Antagonist DM8XESD RN Small molecule inhibitor of apoptosis proteins antagonists: a patent review.Expert Opin Ther Pat. 2015 Jul;25(7):755-74. DM8XESD RU https://www.ncbi.nlm.nih.gov/pubmed/25980951 DM8XESD DI DM8XESD DM8XESD DN PMID25980951-Compound-42 DM8XESD MI TTR7B60 DM8XESD MN X-linked inhibitor of apoptosis protein (XIAP) DM8XESD MT DTT DM8XESD MA Antagonist DM8XESD RN Small molecule inhibitor of apoptosis proteins antagonists: a patent review.Expert Opin Ther Pat. 2015 Jul;25(7):755-74. DM8XESD RU https://www.ncbi.nlm.nih.gov/pubmed/25980951 DMTJRCS DI DMTJRCS DMTJRCS DN PMID25980951-Compound-43 DMTJRCS MI TTQ5LRD DMTJRCS MN Cellular inhibitor of apoptosis 1 (BIRC2) DMTJRCS MT DTT DMTJRCS MA Antagonist DMTJRCS RN Small molecule inhibitor of apoptosis proteins antagonists: a patent review.Expert Opin Ther Pat. 2015 Jul;25(7):755-74. DMTJRCS RU https://www.ncbi.nlm.nih.gov/pubmed/25980951 DMTJRCS DI DMTJRCS DMTJRCS DN PMID25980951-Compound-43 DMTJRCS MI TTIRY6K DMTJRCS MN Cellular inhibitor of apoptosis 2 (BIRC3) DMTJRCS MT DTT DMTJRCS MA Antagonist DMTJRCS RN Small molecule inhibitor of apoptosis proteins antagonists: a patent review.Expert Opin Ther Pat. 2015 Jul;25(7):755-74. DMTJRCS RU https://www.ncbi.nlm.nih.gov/pubmed/25980951 DMTJRCS DI DMTJRCS DMTJRCS DN PMID25980951-Compound-43 DMTJRCS MI TTR7B60 DMTJRCS MN X-linked inhibitor of apoptosis protein (XIAP) DMTJRCS MT DTT DMTJRCS MA Antagonist DMTJRCS RN Small molecule inhibitor of apoptosis proteins antagonists: a patent review.Expert Opin Ther Pat. 2015 Jul;25(7):755-74. DMTJRCS RU https://www.ncbi.nlm.nih.gov/pubmed/25980951 DMS5896 DI DMS5896 DMS5896 DN PMID25980951-Compound-44 DMS5896 MI TTQ5LRD DMS5896 MN Cellular inhibitor of apoptosis 1 (BIRC2) DMS5896 MT DTT DMS5896 MA Antagonist DMS5896 RN Small molecule inhibitor of apoptosis proteins antagonists: a patent review.Expert Opin Ther Pat. 2015 Jul;25(7):755-74. DMS5896 RU https://www.ncbi.nlm.nih.gov/pubmed/25980951 DMS5896 DI DMS5896 DMS5896 DN PMID25980951-Compound-44 DMS5896 MI TTIRY6K DMS5896 MN Cellular inhibitor of apoptosis 2 (BIRC3) DMS5896 MT DTT DMS5896 MA Antagonist DMS5896 RN Small molecule inhibitor of apoptosis proteins antagonists: a patent review.Expert Opin Ther Pat. 2015 Jul;25(7):755-74. DMS5896 RU https://www.ncbi.nlm.nih.gov/pubmed/25980951 DMS5896 DI DMS5896 DMS5896 DN PMID25980951-Compound-44 DMS5896 MI TTR7B60 DMS5896 MN X-linked inhibitor of apoptosis protein (XIAP) DMS5896 MT DTT DMS5896 MA Antagonist DMS5896 RN Small molecule inhibitor of apoptosis proteins antagonists: a patent review.Expert Opin Ther Pat. 2015 Jul;25(7):755-74. DMS5896 RU https://www.ncbi.nlm.nih.gov/pubmed/25980951 DM1EU06 DI DM1EU06 DM1EU06 DN PMID25980951-Compound-45 DM1EU06 MI TTR7B60 DM1EU06 MN X-linked inhibitor of apoptosis protein (XIAP) DM1EU06 MT DTT DM1EU06 MA Antagonist DM1EU06 RN Small molecule inhibitor of apoptosis proteins antagonists: a patent review.Expert Opin Ther Pat. 2015 Jul;25(7):755-74. DM1EU06 RU https://www.ncbi.nlm.nih.gov/pubmed/25980951 DMB3IZT DI DMB3IZT DMB3IZT DN PMID25980951-Compound-5 DMB3IZT MI TTQ5LRD DMB3IZT MN Cellular inhibitor of apoptosis 1 (BIRC2) DMB3IZT MT DTT DMB3IZT MA Antagonist DMB3IZT RN Small molecule inhibitor of apoptosis proteins antagonists: a patent review.Expert Opin Ther Pat. 2015 Jul;25(7):755-74. DMB3IZT RU https://www.ncbi.nlm.nih.gov/pubmed/25980951 DMB3IZT DI DMB3IZT DMB3IZT DN PMID25980951-Compound-5 DMB3IZT MI TTR7B60 DMB3IZT MN X-linked inhibitor of apoptosis protein (XIAP) DMB3IZT MT DTT DMB3IZT MA Antagonist DMB3IZT RN Small molecule inhibitor of apoptosis proteins antagonists: a patent review.Expert Opin Ther Pat. 2015 Jul;25(7):755-74. DMB3IZT RU https://www.ncbi.nlm.nih.gov/pubmed/25980951 DMVSW5N DI DMVSW5N DMVSW5N DN PMID25980951-Compound-6 DMVSW5N MI TTQ5LRD DMVSW5N MN Cellular inhibitor of apoptosis 1 (BIRC2) DMVSW5N MT DTT DMVSW5N MA Antagonist DMVSW5N RN Small molecule inhibitor of apoptosis proteins antagonists: a patent review.Expert Opin Ther Pat. 2015 Jul;25(7):755-74. DMVSW5N RU https://www.ncbi.nlm.nih.gov/pubmed/25980951 DMVSW5N DI DMVSW5N DMVSW5N DN PMID25980951-Compound-6 DMVSW5N MI TTHZ8TA DMVSW5N MN Melanoma inhibitor of apoptosis protein (ML-IAP) DMVSW5N MT DTT DMVSW5N MA Antagonist DMVSW5N RN Small molecule inhibitor of apoptosis proteins antagonists: a patent review.Expert Opin Ther Pat. 2015 Jul;25(7):755-74. DMVSW5N RU https://www.ncbi.nlm.nih.gov/pubmed/25980951 DMVSW5N DI DMVSW5N DMVSW5N DN PMID25980951-Compound-6 DMVSW5N MI TTR7B60 DMVSW5N MN X-linked inhibitor of apoptosis protein (XIAP) DMVSW5N MT DTT DMVSW5N MA Antagonist DMVSW5N RN Small molecule inhibitor of apoptosis proteins antagonists: a patent review.Expert Opin Ther Pat. 2015 Jul;25(7):755-74. DMVSW5N RU https://www.ncbi.nlm.nih.gov/pubmed/25980951 DMF8V5J DI DMF8V5J DMF8V5J DN PMID25980951-Compound-7 DMF8V5J MI TTQ5LRD DMF8V5J MN Cellular inhibitor of apoptosis 1 (BIRC2) DMF8V5J MT DTT DMF8V5J MA Antagonist DMF8V5J RN Small molecule inhibitor of apoptosis proteins antagonists: a patent review.Expert Opin Ther Pat. 2015 Jul;25(7):755-74. DMF8V5J RU https://www.ncbi.nlm.nih.gov/pubmed/25980951 DMF8V5J DI DMF8V5J DMF8V5J DN PMID25980951-Compound-7 DMF8V5J MI TTR7B60 DMF8V5J MN X-linked inhibitor of apoptosis protein (XIAP) DMF8V5J MT DTT DMF8V5J MA Antagonist DMF8V5J RN Small molecule inhibitor of apoptosis proteins antagonists: a patent review.Expert Opin Ther Pat. 2015 Jul;25(7):755-74. DMF8V5J RU https://www.ncbi.nlm.nih.gov/pubmed/25980951 DM89LF0 DI DM89LF0 DM89LF0 DN PMID25991433-Compound-A1 DM89LF0 MI TTH6V3D DM89LF0 MN Cyclin-dependent kinase 1 (CDK1) DM89LF0 MT DTT DM89LF0 MA Inhibitor DM89LF0 RN c-Jun N-terminal kinase inhibitors: a patent review (2010 - 2014).Expert Opin Ther Pat. 2015;25(8):849-72. DM89LF0 RU https://www.ncbi.nlm.nih.gov/pubmed/25991433 DM89LF0 DI DM89LF0 DM89LF0 DN PMID25991433-Compound-A1 DM89LF0 MI TT7HF4W DM89LF0 MN Cyclin-dependent kinase 2 (CDK2) DM89LF0 MT DTT DM89LF0 MA Inhibitor DM89LF0 RN c-Jun N-terminal kinase inhibitors: a patent review (2010 - 2014).Expert Opin Ther Pat. 2015;25(8):849-72. DM89LF0 RU https://www.ncbi.nlm.nih.gov/pubmed/25991433 DM89LF0 DI DM89LF0 DM89LF0 DN PMID25991433-Compound-A1 DM89LF0 MI TT0PG8F DM89LF0 MN Cyclin-dependent kinase 4 (CDK4) DM89LF0 MT DTT DM89LF0 MA Inhibitor DM89LF0 RN c-Jun N-terminal kinase inhibitors: a patent review (2010 - 2014).Expert Opin Ther Pat. 2015;25(8):849-72. DM89LF0 RU https://www.ncbi.nlm.nih.gov/pubmed/25991433 DM89LF0 DI DM89LF0 DM89LF0 DN PMID25991433-Compound-A1 DM89LF0 MI TTQBR95 DM89LF0 MN Stress-activated protein kinase 2a (p38 alpha) DM89LF0 MT DTT DM89LF0 MA Inhibitor DM89LF0 RN c-Jun N-terminal kinase inhibitors: a patent review (2010 - 2014).Expert Opin Ther Pat. 2015;25(8):849-72. DM89LF0 RU https://www.ncbi.nlm.nih.gov/pubmed/25991433 DM89LF0 DI DM89LF0 DM89LF0 DN PMID25991433-Compound-A1 DM89LF0 MI TT0K6EO DM89LF0 MN Stress-activated protein kinase JNK1 (JNK1) DM89LF0 MT DTT DM89LF0 MA Inhibitor DM89LF0 RN c-Jun N-terminal kinase inhibitors: a patent review (2010 - 2014).Expert Opin Ther Pat. 2015;25(8):849-72. DM89LF0 RU https://www.ncbi.nlm.nih.gov/pubmed/25991433 DM89LF0 DI DM89LF0 DM89LF0 DN PMID25991433-Compound-A1 DM89LF0 MI TTHS0U8 DM89LF0 MN Stress-activated protein kinase JNK2 (JNK2) DM89LF0 MT DTT DM89LF0 MA Inhibitor DM89LF0 RN c-Jun N-terminal kinase inhibitors: a patent review (2010 - 2014).Expert Opin Ther Pat. 2015;25(8):849-72. DM89LF0 RU https://www.ncbi.nlm.nih.gov/pubmed/25991433 DM89LF0 DI DM89LF0 DM89LF0 DN PMID25991433-Compound-A1 DM89LF0 MI TT056SO DM89LF0 MN Stress-activated protein kinase JNK3 (JNK3) DM89LF0 MT DTT DM89LF0 MA Inhibitor DM89LF0 RN c-Jun N-terminal kinase inhibitors: a patent review (2010 - 2014).Expert Opin Ther Pat. 2015;25(8):849-72. DM89LF0 RU https://www.ncbi.nlm.nih.gov/pubmed/25991433 DM39NBT DI DM39NBT DM39NBT DN PMID25991433-Compound-A10 DM39NBT MI TT0K6EO DM39NBT MN Stress-activated protein kinase JNK1 (JNK1) DM39NBT MT DTT DM39NBT MA Inhibitor DM39NBT RN c-Jun N-terminal kinase inhibitors: a patent review (2010 - 2014).Expert Opin Ther Pat. 2015;25(8):849-72. DM39NBT RU https://www.ncbi.nlm.nih.gov/pubmed/25991433 DM39NBT DI DM39NBT DM39NBT DN PMID25991433-Compound-A10 DM39NBT MI TTHS0U8 DM39NBT MN Stress-activated protein kinase JNK2 (JNK2) DM39NBT MT DTT DM39NBT MA Inhibitor DM39NBT RN c-Jun N-terminal kinase inhibitors: a patent review (2010 - 2014).Expert Opin Ther Pat. 2015;25(8):849-72. DM39NBT RU https://www.ncbi.nlm.nih.gov/pubmed/25991433 DMD59C2 DI DMD59C2 DMD59C2 DN PMID25991433-Compound-A11 DMD59C2 MI TT0K6EO DMD59C2 MN Stress-activated protein kinase JNK1 (JNK1) DMD59C2 MT DTT DMD59C2 MA Inhibitor DMD59C2 RN c-Jun N-terminal kinase inhibitors: a patent review (2010 - 2014).Expert Opin Ther Pat. 2015;25(8):849-72. DMD59C2 RU https://www.ncbi.nlm.nih.gov/pubmed/25991433 DMD59C2 DI DMD59C2 DMD59C2 DN PMID25991433-Compound-A11 DMD59C2 MI TTHS0U8 DMD59C2 MN Stress-activated protein kinase JNK2 (JNK2) DMD59C2 MT DTT DMD59C2 MA Inhibitor DMD59C2 RN c-Jun N-terminal kinase inhibitors: a patent review (2010 - 2014).Expert Opin Ther Pat. 2015;25(8):849-72. DMD59C2 RU https://www.ncbi.nlm.nih.gov/pubmed/25991433 DMX7MHC DI DMX7MHC DMX7MHC DN PMID25991433-Compound-A2 DMX7MHC MI TT0K6EO DMX7MHC MN Stress-activated protein kinase JNK1 (JNK1) DMX7MHC MT DTT DMX7MHC MA Inhibitor DMX7MHC RN c-Jun N-terminal kinase inhibitors: a patent review (2010 - 2014).Expert Opin Ther Pat. 2015;25(8):849-72. DMX7MHC RU https://www.ncbi.nlm.nih.gov/pubmed/25991433 DMX7MHC DI DMX7MHC DMX7MHC DN PMID25991433-Compound-A2 DMX7MHC MI TTHS0U8 DMX7MHC MN Stress-activated protein kinase JNK2 (JNK2) DMX7MHC MT DTT DMX7MHC MA Inhibitor DMX7MHC RN c-Jun N-terminal kinase inhibitors: a patent review (2010 - 2014).Expert Opin Ther Pat. 2015;25(8):849-72. DMX7MHC RU https://www.ncbi.nlm.nih.gov/pubmed/25991433 DMJ1X53 DI DMJ1X53 DMJ1X53 DN PMID25991433-Compound-A3 DMJ1X53 MI TT0K6EO DMJ1X53 MN Stress-activated protein kinase JNK1 (JNK1) DMJ1X53 MT DTT DMJ1X53 MA Inhibitor DMJ1X53 RN c-Jun N-terminal kinase inhibitors: a patent review (2010 - 2014).Expert Opin Ther Pat. 2015;25(8):849-72. DMJ1X53 RU https://www.ncbi.nlm.nih.gov/pubmed/25991433 DMJ1X53 DI DMJ1X53 DMJ1X53 DN PMID25991433-Compound-A3 DMJ1X53 MI TTHS0U8 DMJ1X53 MN Stress-activated protein kinase JNK2 (JNK2) DMJ1X53 MT DTT DMJ1X53 MA Inhibitor DMJ1X53 RN c-Jun N-terminal kinase inhibitors: a patent review (2010 - 2014).Expert Opin Ther Pat. 2015;25(8):849-72. DMJ1X53 RU https://www.ncbi.nlm.nih.gov/pubmed/25991433 DM5YD1K DI DM5YD1K DM5YD1K DN PMID25991433-Compound-A5 DM5YD1K MI TT0K6EO DM5YD1K MN Stress-activated protein kinase JNK1 (JNK1) DM5YD1K MT DTT DM5YD1K MA Inhibitor DM5YD1K RN c-Jun N-terminal kinase inhibitors: a patent review (2010 - 2014).Expert Opin Ther Pat. 2015;25(8):849-72. DM5YD1K RU https://www.ncbi.nlm.nih.gov/pubmed/25991433 DM5YD1K DI DM5YD1K DM5YD1K DN PMID25991433-Compound-A5 DM5YD1K MI TTHS0U8 DM5YD1K MN Stress-activated protein kinase JNK2 (JNK2) DM5YD1K MT DTT DM5YD1K MA Inhibitor DM5YD1K RN c-Jun N-terminal kinase inhibitors: a patent review (2010 - 2014).Expert Opin Ther Pat. 2015;25(8):849-72. DM5YD1K RU https://www.ncbi.nlm.nih.gov/pubmed/25991433 DMFSB9Y DI DMFSB9Y DMFSB9Y DN PMID25991433-Compound-A6 DMFSB9Y MI TT0K6EO DMFSB9Y MN Stress-activated protein kinase JNK1 (JNK1) DMFSB9Y MT DTT DMFSB9Y MA Inhibitor DMFSB9Y RN c-Jun N-terminal kinase inhibitors: a patent review (2010 - 2014).Expert Opin Ther Pat. 2015;25(8):849-72. DMFSB9Y RU https://www.ncbi.nlm.nih.gov/pubmed/25991433 DMFSB9Y DI DMFSB9Y DMFSB9Y DN PMID25991433-Compound-A6 DMFSB9Y MI TTHS0U8 DMFSB9Y MN Stress-activated protein kinase JNK2 (JNK2) DMFSB9Y MT DTT DMFSB9Y MA Inhibitor DMFSB9Y RN c-Jun N-terminal kinase inhibitors: a patent review (2010 - 2014).Expert Opin Ther Pat. 2015;25(8):849-72. DMFSB9Y RU https://www.ncbi.nlm.nih.gov/pubmed/25991433 DM2ISDH DI DM2ISDH DM2ISDH DN PMID25991433-Compound-A7 DM2ISDH MI TT0K6EO DM2ISDH MN Stress-activated protein kinase JNK1 (JNK1) DM2ISDH MT DTT DM2ISDH MA Inhibitor DM2ISDH RN c-Jun N-terminal kinase inhibitors: a patent review (2010 - 2014).Expert Opin Ther Pat. 2015;25(8):849-72. DM2ISDH RU https://www.ncbi.nlm.nih.gov/pubmed/25991433 DM2ISDH DI DM2ISDH DM2ISDH DN PMID25991433-Compound-A7 DM2ISDH MI TTHS0U8 DM2ISDH MN Stress-activated protein kinase JNK2 (JNK2) DM2ISDH MT DTT DM2ISDH MA Inhibitor DM2ISDH RN c-Jun N-terminal kinase inhibitors: a patent review (2010 - 2014).Expert Opin Ther Pat. 2015;25(8):849-72. DM2ISDH RU https://www.ncbi.nlm.nih.gov/pubmed/25991433 DMHG4WD DI DMHG4WD DMHG4WD DN PMID25991433-Compound-A8 DMHG4WD MI TT0K6EO DMHG4WD MN Stress-activated protein kinase JNK1 (JNK1) DMHG4WD MT DTT DMHG4WD MA Inhibitor DMHG4WD RN c-Jun N-terminal kinase inhibitors: a patent review (2010 - 2014).Expert Opin Ther Pat. 2015;25(8):849-72. DMHG4WD RU https://www.ncbi.nlm.nih.gov/pubmed/25991433 DMHG4WD DI DMHG4WD DMHG4WD DN PMID25991433-Compound-A8 DMHG4WD MI TTHS0U8 DMHG4WD MN Stress-activated protein kinase JNK2 (JNK2) DMHG4WD MT DTT DMHG4WD MA Inhibitor DMHG4WD RN c-Jun N-terminal kinase inhibitors: a patent review (2010 - 2014).Expert Opin Ther Pat. 2015;25(8):849-72. DMHG4WD RU https://www.ncbi.nlm.nih.gov/pubmed/25991433 DMPYCIM DI DMPYCIM DMPYCIM DN PMID25991433-Compound-A9 DMPYCIM MI TT0K6EO DMPYCIM MN Stress-activated protein kinase JNK1 (JNK1) DMPYCIM MT DTT DMPYCIM MA Inhibitor DMPYCIM RN c-Jun N-terminal kinase inhibitors: a patent review (2010 - 2014).Expert Opin Ther Pat. 2015;25(8):849-72. DMPYCIM RU https://www.ncbi.nlm.nih.gov/pubmed/25991433 DMPYCIM DI DMPYCIM DMPYCIM DN PMID25991433-Compound-A9 DMPYCIM MI TTHS0U8 DMPYCIM MN Stress-activated protein kinase JNK2 (JNK2) DMPYCIM MT DTT DMPYCIM MA Inhibitor DMPYCIM RN c-Jun N-terminal kinase inhibitors: a patent review (2010 - 2014).Expert Opin Ther Pat. 2015;25(8):849-72. DMPYCIM RU https://www.ncbi.nlm.nih.gov/pubmed/25991433 DMJTO69 DI DMJTO69 DMJTO69 DN PMID25991433-Compound-B1 DMJTO69 MI TTVOE6D DMJTO69 MN Mitogen-activated protein kinase (MAPK) DMJTO69 MT DTT DMJTO69 MA Inhibitor DMJTO69 RN c-Jun N-terminal kinase inhibitors: a patent review (2010 - 2014).Expert Opin Ther Pat. 2015;25(8):849-72. DMJTO69 RU https://www.ncbi.nlm.nih.gov/pubmed/25991433 DMTYQOF DI DMTYQOF DMTYQOF DN PMID25991433-Compound-B2 DMTYQOF MI TTVOE6D DMTYQOF MN Mitogen-activated protein kinase (MAPK) DMTYQOF MT DTT DMTYQOF MA Inhibitor DMTYQOF RN c-Jun N-terminal kinase inhibitors: a patent review (2010 - 2014).Expert Opin Ther Pat. 2015;25(8):849-72. DMTYQOF RU https://www.ncbi.nlm.nih.gov/pubmed/25991433 DMWSGV2 DI DMWSGV2 DMWSGV2 DN PMID25991433-Compound-B3 DMWSGV2 MI TTVOE6D DMWSGV2 MN Mitogen-activated protein kinase (MAPK) DMWSGV2 MT DTT DMWSGV2 MA Inhibitor DMWSGV2 RN c-Jun N-terminal kinase inhibitors: a patent review (2010 - 2014).Expert Opin Ther Pat. 2015;25(8):849-72. DMWSGV2 RU https://www.ncbi.nlm.nih.gov/pubmed/25991433 DM3KWFQ DI DM3KWFQ DM3KWFQ DN PMID25991433-Compound-C1 DM3KWFQ MI TTHS0U8 DM3KWFQ MN Stress-activated protein kinase JNK2 (JNK2) DM3KWFQ MT DTT DM3KWFQ MA Inhibitor DM3KWFQ RN c-Jun N-terminal kinase inhibitors: a patent review (2010 - 2014).Expert Opin Ther Pat. 2015;25(8):849-72. DM3KWFQ RU https://www.ncbi.nlm.nih.gov/pubmed/25991433 DMOAU09 DI DMOAU09 DMOAU09 DN PMID25991433-Compound-C2 DMOAU09 MI TTVOE6D DMOAU09 MN Mitogen-activated protein kinase (MAPK) DMOAU09 MT DTT DMOAU09 MA Inhibitor DMOAU09 RN c-Jun N-terminal kinase inhibitors: a patent review (2010 - 2014).Expert Opin Ther Pat. 2015;25(8):849-72. DMOAU09 RU https://www.ncbi.nlm.nih.gov/pubmed/25991433 DMSKWBE DI DMSKWBE DMSKWBE DN PMID25991433-Compound-C3 DMSKWBE MI TTVOE6D DMSKWBE MN Mitogen-activated protein kinase (MAPK) DMSKWBE MT DTT DMSKWBE MA Inhibitor DMSKWBE RN c-Jun N-terminal kinase inhibitors: a patent review (2010 - 2014).Expert Opin Ther Pat. 2015;25(8):849-72. DMSKWBE RU https://www.ncbi.nlm.nih.gov/pubmed/25991433 DMXSK8Y DI DMXSK8Y DMXSK8Y DN PMID25991433-Compound-D1 DMXSK8Y MI TT0K6EO DMXSK8Y MN Stress-activated protein kinase JNK1 (JNK1) DMXSK8Y MT DTT DMXSK8Y MA Inhibitor DMXSK8Y RN c-Jun N-terminal kinase inhibitors: a patent review (2010 - 2014).Expert Opin Ther Pat. 2015;25(8):849-72. DMXSK8Y RU https://www.ncbi.nlm.nih.gov/pubmed/25991433 DMXSK8Y DI DMXSK8Y DMXSK8Y DN PMID25991433-Compound-D1 DMXSK8Y MI TTHS0U8 DMXSK8Y MN Stress-activated protein kinase JNK2 (JNK2) DMXSK8Y MT DTT DMXSK8Y MA Inhibitor DMXSK8Y RN c-Jun N-terminal kinase inhibitors: a patent review (2010 - 2014).Expert Opin Ther Pat. 2015;25(8):849-72. DMXSK8Y RU https://www.ncbi.nlm.nih.gov/pubmed/25991433 DMLWSNA DI DMLWSNA DMLWSNA DN PMID25991433-Compound-D2 DMLWSNA MI TT0K6EO DMLWSNA MN Stress-activated protein kinase JNK1 (JNK1) DMLWSNA MT DTT DMLWSNA MA Inhibitor DMLWSNA RN c-Jun N-terminal kinase inhibitors: a patent review (2010 - 2014).Expert Opin Ther Pat. 2015;25(8):849-72. DMLWSNA RU https://www.ncbi.nlm.nih.gov/pubmed/25991433 DMLWSNA DI DMLWSNA DMLWSNA DN PMID25991433-Compound-D2 DMLWSNA MI TTHS0U8 DMLWSNA MN Stress-activated protein kinase JNK2 (JNK2) DMLWSNA MT DTT DMLWSNA MA Inhibitor DMLWSNA RN c-Jun N-terminal kinase inhibitors: a patent review (2010 - 2014).Expert Opin Ther Pat. 2015;25(8):849-72. DMLWSNA RU https://www.ncbi.nlm.nih.gov/pubmed/25991433 DMKWFVP DI DMKWFVP DMKWFVP DN PMID25991433-Compound-E1 DMKWFVP MI TT0K6EO DMKWFVP MN Stress-activated protein kinase JNK1 (JNK1) DMKWFVP MT DTT DMKWFVP MA Inhibitor DMKWFVP RN c-Jun N-terminal kinase inhibitors: a patent review (2010 - 2014).Expert Opin Ther Pat. 2015;25(8):849-72. DMKWFVP RU https://www.ncbi.nlm.nih.gov/pubmed/25991433 DM8YR1V DI DM8YR1V DM8YR1V DN PMID25991433-Compound-E2 DM8YR1V MI TT0K6EO DM8YR1V MN Stress-activated protein kinase JNK1 (JNK1) DM8YR1V MT DTT DM8YR1V MA Inhibitor DM8YR1V RN c-Jun N-terminal kinase inhibitors: a patent review (2010 - 2014).Expert Opin Ther Pat. 2015;25(8):849-72. DM8YR1V RU https://www.ncbi.nlm.nih.gov/pubmed/25991433 DM62XNE DI DM62XNE DM62XNE DN PMID25991433-Compound-E3 DM62XNE MI TT0K6EO DM62XNE MN Stress-activated protein kinase JNK1 (JNK1) DM62XNE MT DTT DM62XNE MA Inhibitor DM62XNE RN c-Jun N-terminal kinase inhibitors: a patent review (2010 - 2014).Expert Opin Ther Pat. 2015;25(8):849-72. DM62XNE RU https://www.ncbi.nlm.nih.gov/pubmed/25991433 DM1VHYX DI DM1VHYX DM1VHYX DN PMID25991433-Compound-E4 DM1VHYX MI TT0K6EO DM1VHYX MN Stress-activated protein kinase JNK1 (JNK1) DM1VHYX MT DTT DM1VHYX MA Inhibitor DM1VHYX RN c-Jun N-terminal kinase inhibitors: a patent review (2010 - 2014).Expert Opin Ther Pat. 2015;25(8):849-72. DM1VHYX RU https://www.ncbi.nlm.nih.gov/pubmed/25991433 DM2ZCTW DI DM2ZCTW DM2ZCTW DN PMID25991433-Compound-E5 DM2ZCTW MI TT0K6EO DM2ZCTW MN Stress-activated protein kinase JNK1 (JNK1) DM2ZCTW MT DTT DM2ZCTW MA Inhibitor DM2ZCTW RN c-Jun N-terminal kinase inhibitors: a patent review (2010 - 2014).Expert Opin Ther Pat. 2015;25(8):849-72. DM2ZCTW RU https://www.ncbi.nlm.nih.gov/pubmed/25991433 DM536JN DI DM536JN DM536JN DN PMID25991433-Compound-Eb DM536JN MI TT0K6EO DM536JN MN Stress-activated protein kinase JNK1 (JNK1) DM536JN MT DTT DM536JN MA Inhibitor DM536JN RN c-Jun N-terminal kinase inhibitors: a patent review (2010 - 2014).Expert Opin Ther Pat. 2015;25(8):849-72. DM536JN RU https://www.ncbi.nlm.nih.gov/pubmed/25991433 DMFS2YL DI DMFS2YL DMFS2YL DN PMID25991433-Compound-F1 DMFS2YL MI TTVOE6D DMFS2YL MN Mitogen-activated protein kinase (MAPK) DMFS2YL MT DTT DMFS2YL MA Inhibitor DMFS2YL RN c-Jun N-terminal kinase inhibitors: a patent review (2010 - 2014).Expert Opin Ther Pat. 2015;25(8):849-72. DMFS2YL RU https://www.ncbi.nlm.nih.gov/pubmed/25991433 DM37VIQ DI DM37VIQ DM37VIQ DN PMID25991433-Compound-F2 DM37VIQ MI TTQBR95 DM37VIQ MN Stress-activated protein kinase 2a (p38 alpha) DM37VIQ MT DTT DM37VIQ MA Inhibitor DM37VIQ RN c-Jun N-terminal kinase inhibitors: a patent review (2010 - 2014).Expert Opin Ther Pat. 2015;25(8):849-72. DM37VIQ RU https://www.ncbi.nlm.nih.gov/pubmed/25991433 DM37VIQ DI DM37VIQ DM37VIQ DN PMID25991433-Compound-F2 DM37VIQ MI TT0K6EO DM37VIQ MN Stress-activated protein kinase JNK1 (JNK1) DM37VIQ MT DTT DM37VIQ MA Inhibitor DM37VIQ RN c-Jun N-terminal kinase inhibitors: a patent review (2010 - 2014).Expert Opin Ther Pat. 2015;25(8):849-72. DM37VIQ RU https://www.ncbi.nlm.nih.gov/pubmed/25991433 DM37VIQ DI DM37VIQ DM37VIQ DN PMID25991433-Compound-F2 DM37VIQ MI TTHS0U8 DM37VIQ MN Stress-activated protein kinase JNK2 (JNK2) DM37VIQ MT DTT DM37VIQ MA Inhibitor DM37VIQ RN c-Jun N-terminal kinase inhibitors: a patent review (2010 - 2014).Expert Opin Ther Pat. 2015;25(8):849-72. DM37VIQ RU https://www.ncbi.nlm.nih.gov/pubmed/25991433 DM37VIQ DI DM37VIQ DM37VIQ DN PMID25991433-Compound-F2 DM37VIQ MI TT056SO DM37VIQ MN Stress-activated protein kinase JNK3 (JNK3) DM37VIQ MT DTT DM37VIQ MA Inhibitor DM37VIQ RN c-Jun N-terminal kinase inhibitors: a patent review (2010 - 2014).Expert Opin Ther Pat. 2015;25(8):849-72. DM37VIQ RU https://www.ncbi.nlm.nih.gov/pubmed/25991433 DMHS3ZW DI DMHS3ZW DMHS3ZW DN PMID25991433-Compound-G1 DMHS3ZW MI TT0K6EO DMHS3ZW MN Stress-activated protein kinase JNK1 (JNK1) DMHS3ZW MT DTT DMHS3ZW MA Inhibitor DMHS3ZW RN c-Jun N-terminal kinase inhibitors: a patent review (2010 - 2014).Expert Opin Ther Pat. 2015;25(8):849-72. DMHS3ZW RU https://www.ncbi.nlm.nih.gov/pubmed/25991433 DMU3XBH DI DMU3XBH DMU3XBH DN PMID25991433-Compound-G2 DMU3XBH MI TT0K6EO DMU3XBH MN Stress-activated protein kinase JNK1 (JNK1) DMU3XBH MT DTT DMU3XBH MA Inhibitor DMU3XBH RN c-Jun N-terminal kinase inhibitors: a patent review (2010 - 2014).Expert Opin Ther Pat. 2015;25(8):849-72. DMU3XBH RU https://www.ncbi.nlm.nih.gov/pubmed/25991433 DMACWQY DI DMACWQY DMACWQY DN PMID25991433-Compound-G4 DMACWQY MI TT0K6EO DMACWQY MN Stress-activated protein kinase JNK1 (JNK1) DMACWQY MT DTT DMACWQY MA Inhibitor DMACWQY RN c-Jun N-terminal kinase inhibitors: a patent review (2010 - 2014).Expert Opin Ther Pat. 2015;25(8):849-72. DMACWQY RU https://www.ncbi.nlm.nih.gov/pubmed/25991433 DMRJ1KY DI DMRJ1KY DMRJ1KY DN PMID25991433-Compound-G5 DMRJ1KY MI TT0K6EO DMRJ1KY MN Stress-activated protein kinase JNK1 (JNK1) DMRJ1KY MT DTT DMRJ1KY MA Inhibitor DMRJ1KY RN c-Jun N-terminal kinase inhibitors: a patent review (2010 - 2014).Expert Opin Ther Pat. 2015;25(8):849-72. DMRJ1KY RU https://www.ncbi.nlm.nih.gov/pubmed/25991433 DM0Q37R DI DM0Q37R DM0Q37R DN PMID25991433-Compound-H1 DM0Q37R MI TT0K6EO DM0Q37R MN Stress-activated protein kinase JNK1 (JNK1) DM0Q37R MT DTT DM0Q37R MA Inhibitor DM0Q37R RN c-Jun N-terminal kinase inhibitors: a patent review (2010 - 2014).Expert Opin Ther Pat. 2015;25(8):849-72. DM0Q37R RU https://www.ncbi.nlm.nih.gov/pubmed/25991433 DMZ9BTN DI DMZ9BTN DMZ9BTN DN PMID25991433-Compound-H2 DMZ9BTN MI TT0K6EO DMZ9BTN MN Stress-activated protein kinase JNK1 (JNK1) DMZ9BTN MT DTT DMZ9BTN MA Inhibitor DMZ9BTN RN c-Jun N-terminal kinase inhibitors: a patent review (2010 - 2014).Expert Opin Ther Pat. 2015;25(8):849-72. DMZ9BTN RU https://www.ncbi.nlm.nih.gov/pubmed/25991433 DMQKLX0 DI DMQKLX0 DMQKLX0 DN PMID25991433-Compound-H3 DMQKLX0 MI TT0K6EO DMQKLX0 MN Stress-activated protein kinase JNK1 (JNK1) DMQKLX0 MT DTT DMQKLX0 MA Inhibitor DMQKLX0 RN c-Jun N-terminal kinase inhibitors: a patent review (2010 - 2014).Expert Opin Ther Pat. 2015;25(8):849-72. DMQKLX0 RU https://www.ncbi.nlm.nih.gov/pubmed/25991433 DMQGUMN DI DMQGUMN DMQGUMN DN PMID25991433-Compound-J1 DMQGUMN MI TTVOE6D DMQGUMN MN Mitogen-activated protein kinase (MAPK) DMQGUMN MT DTT DMQGUMN MA Inhibitor DMQGUMN RN c-Jun N-terminal kinase inhibitors: a patent review (2010 - 2014).Expert Opin Ther Pat. 2015;25(8):849-72. DMQGUMN RU https://www.ncbi.nlm.nih.gov/pubmed/25991433 DMZSOCK DI DMZSOCK DMZSOCK DN PMID25991433-Compound-J2 DMZSOCK MI TT0K6EO DMZSOCK MN Stress-activated protein kinase JNK1 (JNK1) DMZSOCK MT DTT DMZSOCK MA Inhibitor DMZSOCK RN c-Jun N-terminal kinase inhibitors: a patent review (2010 - 2014).Expert Opin Ther Pat. 2015;25(8):849-72. DMZSOCK RU https://www.ncbi.nlm.nih.gov/pubmed/25991433 DMZSOCK DI DMZSOCK DMZSOCK DN PMID25991433-Compound-J2 DMZSOCK MI TTHS0U8 DMZSOCK MN Stress-activated protein kinase JNK2 (JNK2) DMZSOCK MT DTT DMZSOCK MA Inhibitor DMZSOCK RN c-Jun N-terminal kinase inhibitors: a patent review (2010 - 2014).Expert Opin Ther Pat. 2015;25(8):849-72. DMZSOCK RU https://www.ncbi.nlm.nih.gov/pubmed/25991433 DMZSOCK DI DMZSOCK DMZSOCK DN PMID25991433-Compound-J2 DMZSOCK MI TT056SO DMZSOCK MN Stress-activated protein kinase JNK3 (JNK3) DMZSOCK MT DTT DMZSOCK MA Inhibitor DMZSOCK RN c-Jun N-terminal kinase inhibitors: a patent review (2010 - 2014).Expert Opin Ther Pat. 2015;25(8):849-72. DMZSOCK RU https://www.ncbi.nlm.nih.gov/pubmed/25991433 DM17P3F DI DM17P3F DM17P3F DN PMID25991433-Compound-J3 DM17P3F MI TT0K6EO DM17P3F MN Stress-activated protein kinase JNK1 (JNK1) DM17P3F MT DTT DM17P3F MA Inhibitor DM17P3F RN c-Jun N-terminal kinase inhibitors: a patent review (2010 - 2014).Expert Opin Ther Pat. 2015;25(8):849-72. DM17P3F RU https://www.ncbi.nlm.nih.gov/pubmed/25991433 DM17P3F DI DM17P3F DM17P3F DN PMID25991433-Compound-J3 DM17P3F MI TTHS0U8 DM17P3F MN Stress-activated protein kinase JNK2 (JNK2) DM17P3F MT DTT DM17P3F MA Inhibitor DM17P3F RN c-Jun N-terminal kinase inhibitors: a patent review (2010 - 2014).Expert Opin Ther Pat. 2015;25(8):849-72. DM17P3F RU https://www.ncbi.nlm.nih.gov/pubmed/25991433 DM17P3F DI DM17P3F DM17P3F DN PMID25991433-Compound-J3 DM17P3F MI TT056SO DM17P3F MN Stress-activated protein kinase JNK3 (JNK3) DM17P3F MT DTT DM17P3F MA Inhibitor DM17P3F RN c-Jun N-terminal kinase inhibitors: a patent review (2010 - 2014).Expert Opin Ther Pat. 2015;25(8):849-72. DM17P3F RU https://www.ncbi.nlm.nih.gov/pubmed/25991433 DMU75ZX DI DMU75ZX DMU75ZX DN PMID25991433-Compound-J5 DMU75ZX MI TT0K6EO DMU75ZX MN Stress-activated protein kinase JNK1 (JNK1) DMU75ZX MT DTT DMU75ZX MA Inhibitor DMU75ZX RN c-Jun N-terminal kinase inhibitors: a patent review (2010 - 2014).Expert Opin Ther Pat. 2015;25(8):849-72. DMU75ZX RU https://www.ncbi.nlm.nih.gov/pubmed/25991433 DMU75ZX DI DMU75ZX DMU75ZX DN PMID25991433-Compound-J5 DMU75ZX MI TTHS0U8 DMU75ZX MN Stress-activated protein kinase JNK2 (JNK2) DMU75ZX MT DTT DMU75ZX MA Inhibitor DMU75ZX RN c-Jun N-terminal kinase inhibitors: a patent review (2010 - 2014).Expert Opin Ther Pat. 2015;25(8):849-72. DMU75ZX RU https://www.ncbi.nlm.nih.gov/pubmed/25991433 DMU75ZX DI DMU75ZX DMU75ZX DN PMID25991433-Compound-J5 DMU75ZX MI TT056SO DMU75ZX MN Stress-activated protein kinase JNK3 (JNK3) DMU75ZX MT DTT DMU75ZX MA Inhibitor DMU75ZX RN c-Jun N-terminal kinase inhibitors: a patent review (2010 - 2014).Expert Opin Ther Pat. 2015;25(8):849-72. DMU75ZX RU https://www.ncbi.nlm.nih.gov/pubmed/25991433 DMOWULJ DI DMOWULJ DMOWULJ DN PMID25991433-Compound-J6 DMOWULJ MI TTVOE6D DMOWULJ MN Mitogen-activated protein kinase (MAPK) DMOWULJ MT DTT DMOWULJ MA Inhibitor DMOWULJ RN c-Jun N-terminal kinase inhibitors: a patent review (2010 - 2014).Expert Opin Ther Pat. 2015;25(8):849-72. DMOWULJ RU https://www.ncbi.nlm.nih.gov/pubmed/25991433 DMLT8PA DI DMLT8PA DMLT8PA DN PMID25991433-Compound-K1 DMLT8PA MI TT0K6EO DMLT8PA MN Stress-activated protein kinase JNK1 (JNK1) DMLT8PA MT DTT DMLT8PA MA Inhibitor DMLT8PA RN c-Jun N-terminal kinase inhibitors: a patent review (2010 - 2014).Expert Opin Ther Pat. 2015;25(8):849-72. DMLT8PA RU https://www.ncbi.nlm.nih.gov/pubmed/25991433 DMBS4LE DI DMBS4LE DMBS4LE DN PMID25991433-Compound-K2 DMBS4LE MI TT0K6EO DMBS4LE MN Stress-activated protein kinase JNK1 (JNK1) DMBS4LE MT DTT DMBS4LE MA Inhibitor DMBS4LE RN c-Jun N-terminal kinase inhibitors: a patent review (2010 - 2014).Expert Opin Ther Pat. 2015;25(8):849-72. DMBS4LE RU https://www.ncbi.nlm.nih.gov/pubmed/25991433 DM5U8WT DI DM5U8WT DM5U8WT DN PMID25991433-Compound-L DM5U8WT MI TTVOE6D DM5U8WT MN Mitogen-activated protein kinase (MAPK) DM5U8WT MT DTT DM5U8WT MA Inhibitor DM5U8WT RN c-Jun N-terminal kinase inhibitors: a patent review (2010 - 2014).Expert Opin Ther Pat. 2015;25(8):849-72. DM5U8WT RU https://www.ncbi.nlm.nih.gov/pubmed/25991433 DM2135Y DI DM2135Y DM2135Y DN PMID25991433-Compound-L1 DM2135Y MI TT3ZIJL DM2135Y MN JNK-interacting protein peptide (pepJIP) DM2135Y MT DTT DM2135Y MA Inhibitor DM2135Y RN c-Jun N-terminal kinase inhibitors: a patent review (2010 - 2014).Expert Opin Ther Pat. 2015;25(8):849-72. DM2135Y RU https://www.ncbi.nlm.nih.gov/pubmed/25991433 DM2135Y DI DM2135Y DM2135Y DN PMID25991433-Compound-L1 DM2135Y MI TTQBR95 DM2135Y MN Stress-activated protein kinase 2a (p38 alpha) DM2135Y MT DTT DM2135Y MA Inhibitor DM2135Y RN c-Jun N-terminal kinase inhibitors: a patent review (2010 - 2014).Expert Opin Ther Pat. 2015;25(8):849-72. DM2135Y RU https://www.ncbi.nlm.nih.gov/pubmed/25991433 DM2135Y DI DM2135Y DM2135Y DN PMID25991433-Compound-L1 DM2135Y MI TT0K6EO DM2135Y MN Stress-activated protein kinase JNK1 (JNK1) DM2135Y MT DTT DM2135Y MA Inhibitor DM2135Y RN c-Jun N-terminal kinase inhibitors: a patent review (2010 - 2014).Expert Opin Ther Pat. 2015;25(8):849-72. DM2135Y RU https://www.ncbi.nlm.nih.gov/pubmed/25991433 DM58UO9 DI DM58UO9 DM58UO9 DN PMID25991433-Compound-L2 DM58UO9 MI TT3ZIJL DM58UO9 MN JNK-interacting protein peptide (pepJIP) DM58UO9 MT DTT DM58UO9 MA Inhibitor DM58UO9 RN c-Jun N-terminal kinase inhibitors: a patent review (2010 - 2014).Expert Opin Ther Pat. 2015;25(8):849-72. DM58UO9 RU https://www.ncbi.nlm.nih.gov/pubmed/25991433 DM58UO9 DI DM58UO9 DM58UO9 DN PMID25991433-Compound-L2 DM58UO9 MI TTVOE6D DM58UO9 MN Mitogen-activated protein kinase (MAPK) DM58UO9 MT DTT DM58UO9 MA Inhibitor DM58UO9 RN c-Jun N-terminal kinase inhibitors: a patent review (2010 - 2014).Expert Opin Ther Pat. 2015;25(8):849-72. DM58UO9 RU https://www.ncbi.nlm.nih.gov/pubmed/25991433 DM58UO9 DI DM58UO9 DM58UO9 DN PMID25991433-Compound-L2 DM58UO9 MI TTQBR95 DM58UO9 MN Stress-activated protein kinase 2a (p38 alpha) DM58UO9 MT DTT DM58UO9 MA Inhibitor DM58UO9 RN c-Jun N-terminal kinase inhibitors: a patent review (2010 - 2014).Expert Opin Ther Pat. 2015;25(8):849-72. DM58UO9 RU https://www.ncbi.nlm.nih.gov/pubmed/25991433 DM3LWUR DI DM3LWUR DM3LWUR DN PMID25991433-Compound-L3 DM3LWUR MI TT3ZIJL DM3LWUR MN JNK-interacting protein peptide (pepJIP) DM3LWUR MT DTT DM3LWUR MA Inhibitor DM3LWUR RN c-Jun N-terminal kinase inhibitors: a patent review (2010 - 2014).Expert Opin Ther Pat. 2015;25(8):849-72. DM3LWUR RU https://www.ncbi.nlm.nih.gov/pubmed/25991433 DM3LWUR DI DM3LWUR DM3LWUR DN PMID25991433-Compound-L3 DM3LWUR MI TTVOE6D DM3LWUR MN Mitogen-activated protein kinase (MAPK) DM3LWUR MT DTT DM3LWUR MA Inhibitor DM3LWUR RN c-Jun N-terminal kinase inhibitors: a patent review (2010 - 2014).Expert Opin Ther Pat. 2015;25(8):849-72. DM3LWUR RU https://www.ncbi.nlm.nih.gov/pubmed/25991433 DM3LWUR DI DM3LWUR DM3LWUR DN PMID25991433-Compound-L3 DM3LWUR MI TTQBR95 DM3LWUR MN Stress-activated protein kinase 2a (p38 alpha) DM3LWUR MT DTT DM3LWUR MA Inhibitor DM3LWUR RN c-Jun N-terminal kinase inhibitors: a patent review (2010 - 2014).Expert Opin Ther Pat. 2015;25(8):849-72. DM3LWUR RU https://www.ncbi.nlm.nih.gov/pubmed/25991433 DMN27QB DI DMN27QB DMN27QB DN PMID25991433-Compound-N1 DMN27QB MI TTXKZ8Q DMN27QB MN JNK-interacting protein 1 peptide (pepJIP1) DMN27QB MT DTT DMN27QB MA Inhibitor DMN27QB RN c-Jun N-terminal kinase inhibitors: a patent review (2010 - 2014).Expert Opin Ther Pat. 2015;25(8):849-72. DMN27QB RU https://www.ncbi.nlm.nih.gov/pubmed/25991433 DMN27QB DI DMN27QB DMN27QB DN PMID25991433-Compound-N1 DMN27QB MI TT0K6EO DMN27QB MN Stress-activated protein kinase JNK1 (JNK1) DMN27QB MT DTT DMN27QB MA Inhibitor DMN27QB RN c-Jun N-terminal kinase inhibitors: a patent review (2010 - 2014).Expert Opin Ther Pat. 2015;25(8):849-72. DMN27QB RU https://www.ncbi.nlm.nih.gov/pubmed/25991433 DMXY4BE DI DMXY4BE DMXY4BE DN PMID25991433-Compound-N2 DMXY4BE MI TTVOE6D DMXY4BE MN Mitogen-activated protein kinase (MAPK) DMXY4BE MT DTT DMXY4BE MA Inhibitor DMXY4BE RN c-Jun N-terminal kinase inhibitors: a patent review (2010 - 2014).Expert Opin Ther Pat. 2015;25(8):849-72. DMXY4BE RU https://www.ncbi.nlm.nih.gov/pubmed/25991433 DMLHC5V DI DMLHC5V DMLHC5V DN PMID25991433-Compound-N3 DMLHC5V MI TT3ZIJL DMLHC5V MN JNK-interacting protein peptide (pepJIP) DMLHC5V MT DTT DMLHC5V MA Inhibitor DMLHC5V RN c-Jun N-terminal kinase inhibitors: a patent review (2010 - 2014).Expert Opin Ther Pat. 2015;25(8):849-72. DMLHC5V RU https://www.ncbi.nlm.nih.gov/pubmed/25991433 DMLHC5V DI DMLHC5V DMLHC5V DN PMID25991433-Compound-N3 DMLHC5V MI TT0K6EO DMLHC5V MN Stress-activated protein kinase JNK1 (JNK1) DMLHC5V MT DTT DMLHC5V MA Inhibitor DMLHC5V RN c-Jun N-terminal kinase inhibitors: a patent review (2010 - 2014).Expert Opin Ther Pat. 2015;25(8):849-72. DMLHC5V RU https://www.ncbi.nlm.nih.gov/pubmed/25991433 DMH073T DI DMH073T DMH073T DN PMID25991433-Compound-O1 DMH073T MI TTR2TXZ DMH073T MN Jun N terminal kinase (JNK) DMH073T MT DTT DMH073T MA Inhibitor DMH073T RN c-Jun N-terminal kinase inhibitors: a patent review (2010 - 2014).Expert Opin Ther Pat. 2015;25(8):849-72. DMH073T RU https://www.ncbi.nlm.nih.gov/pubmed/25991433 DMTROIQ DI DMTROIQ DMTROIQ DN PMID25991433-Compound-O2 DMTROIQ MI TTQBR95 DMTROIQ MN Stress-activated protein kinase 2a (p38 alpha) DMTROIQ MT DTT DMTROIQ MA Inhibitor DMTROIQ RN c-Jun N-terminal kinase inhibitors: a patent review (2010 - 2014).Expert Opin Ther Pat. 2015;25(8):849-72. DMTROIQ RU https://www.ncbi.nlm.nih.gov/pubmed/25991433 DMVOWS5 DI DMVOWS5 DMVOWS5 DN PMID25991433-Compound-O3 DMVOWS5 MI TT0K6EO DMVOWS5 MN Stress-activated protein kinase JNK1 (JNK1) DMVOWS5 MT DTT DMVOWS5 MA Inhibitor DMVOWS5 RN c-Jun N-terminal kinase inhibitors: a patent review (2010 - 2014).Expert Opin Ther Pat. 2015;25(8):849-72. DMVOWS5 RU https://www.ncbi.nlm.nih.gov/pubmed/25991433 DMVOWS5 DI DMVOWS5 DMVOWS5 DN PMID25991433-Compound-O3 DMVOWS5 MI TTHS0U8 DMVOWS5 MN Stress-activated protein kinase JNK2 (JNK2) DMVOWS5 MT DTT DMVOWS5 MA Inhibitor DMVOWS5 RN c-Jun N-terminal kinase inhibitors: a patent review (2010 - 2014).Expert Opin Ther Pat. 2015;25(8):849-72. DMVOWS5 RU https://www.ncbi.nlm.nih.gov/pubmed/25991433 DMVOWS5 DI DMVOWS5 DMVOWS5 DN PMID25991433-Compound-O3 DMVOWS5 MI TT056SO DMVOWS5 MN Stress-activated protein kinase JNK3 (JNK3) DMVOWS5 MT DTT DMVOWS5 MA Inhibitor DMVOWS5 RN c-Jun N-terminal kinase inhibitors: a patent review (2010 - 2014).Expert Opin Ther Pat. 2015;25(8):849-72. DMVOWS5 RU https://www.ncbi.nlm.nih.gov/pubmed/25991433 DMD8AX6 DI DMD8AX6 DMD8AX6 DN PMID25991433-Compound-P1 DMD8AX6 MI TT0K6EO DMD8AX6 MN Stress-activated protein kinase JNK1 (JNK1) DMD8AX6 MT DTT DMD8AX6 MA Inhibitor DMD8AX6 RN c-Jun N-terminal kinase inhibitors: a patent review (2010 - 2014).Expert Opin Ther Pat. 2015;25(8):849-72. DMD8AX6 RU https://www.ncbi.nlm.nih.gov/pubmed/25991433 DMD8AX6 DI DMD8AX6 DMD8AX6 DN PMID25991433-Compound-P1 DMD8AX6 MI TTHS0U8 DMD8AX6 MN Stress-activated protein kinase JNK2 (JNK2) DMD8AX6 MT DTT DMD8AX6 MA Inhibitor DMD8AX6 RN c-Jun N-terminal kinase inhibitors: a patent review (2010 - 2014).Expert Opin Ther Pat. 2015;25(8):849-72. DMD8AX6 RU https://www.ncbi.nlm.nih.gov/pubmed/25991433 DMD8AX6 DI DMD8AX6 DMD8AX6 DN PMID25991433-Compound-P1 DMD8AX6 MI TT056SO DMD8AX6 MN Stress-activated protein kinase JNK3 (JNK3) DMD8AX6 MT DTT DMD8AX6 MA Inhibitor DMD8AX6 RN c-Jun N-terminal kinase inhibitors: a patent review (2010 - 2014).Expert Opin Ther Pat. 2015;25(8):849-72. DMD8AX6 RU https://www.ncbi.nlm.nih.gov/pubmed/25991433 DMEGS7U DI DMEGS7U DMEGS7U DN PMID25991433-Compound-P2 DMEGS7U MI TTVOE6D DMEGS7U MN Mitogen-activated protein kinase (MAPK) DMEGS7U MT DTT DMEGS7U MA Inhibitor DMEGS7U RN c-Jun N-terminal kinase inhibitors: a patent review (2010 - 2014).Expert Opin Ther Pat. 2015;25(8):849-72. DMEGS7U RU https://www.ncbi.nlm.nih.gov/pubmed/25991433 DMAFZLP DI DMAFZLP DMAFZLP DN PMID25991433-Compound-P3 DMAFZLP MI TTVOE6D DMAFZLP MN Mitogen-activated protein kinase (MAPK) DMAFZLP MT DTT DMAFZLP MA Inhibitor DMAFZLP RN c-Jun N-terminal kinase inhibitors: a patent review (2010 - 2014).Expert Opin Ther Pat. 2015;25(8):849-72. DMAFZLP RU https://www.ncbi.nlm.nih.gov/pubmed/25991433 DMVF1D6 DI DMVF1D6 DMVF1D6 DN PMID25991433-Compound-P4 DMVF1D6 MI TT0K6EO DMVF1D6 MN Stress-activated protein kinase JNK1 (JNK1) DMVF1D6 MT DTT DMVF1D6 MA Inhibitor DMVF1D6 RN c-Jun N-terminal kinase inhibitors: a patent review (2010 - 2014).Expert Opin Ther Pat. 2015;25(8):849-72. DMVF1D6 RU https://www.ncbi.nlm.nih.gov/pubmed/25991433 DMVF1D6 DI DMVF1D6 DMVF1D6 DN PMID25991433-Compound-P4 DMVF1D6 MI TTHS0U8 DMVF1D6 MN Stress-activated protein kinase JNK2 (JNK2) DMVF1D6 MT DTT DMVF1D6 MA Inhibitor DMVF1D6 RN c-Jun N-terminal kinase inhibitors: a patent review (2010 - 2014).Expert Opin Ther Pat. 2015;25(8):849-72. DMVF1D6 RU https://www.ncbi.nlm.nih.gov/pubmed/25991433 DMVF1D6 DI DMVF1D6 DMVF1D6 DN PMID25991433-Compound-P4 DMVF1D6 MI TT056SO DMVF1D6 MN Stress-activated protein kinase JNK3 (JNK3) DMVF1D6 MT DTT DMVF1D6 MA Inhibitor DMVF1D6 RN c-Jun N-terminal kinase inhibitors: a patent review (2010 - 2014).Expert Opin Ther Pat. 2015;25(8):849-72. DMVF1D6 RU https://www.ncbi.nlm.nih.gov/pubmed/25991433 DM6FCS9 DI DM6FCS9 DM6FCS9 DN PMID25991433-Compound-P5 DM6FCS9 MI TT0K6EO DM6FCS9 MN Stress-activated protein kinase JNK1 (JNK1) DM6FCS9 MT DTT DM6FCS9 MA Inhibitor DM6FCS9 RN c-Jun N-terminal kinase inhibitors: a patent review (2010 - 2014).Expert Opin Ther Pat. 2015;25(8):849-72. DM6FCS9 RU https://www.ncbi.nlm.nih.gov/pubmed/25991433 DM6FCS9 DI DM6FCS9 DM6FCS9 DN PMID25991433-Compound-P5 DM6FCS9 MI TTHS0U8 DM6FCS9 MN Stress-activated protein kinase JNK2 (JNK2) DM6FCS9 MT DTT DM6FCS9 MA Inhibitor DM6FCS9 RN c-Jun N-terminal kinase inhibitors: a patent review (2010 - 2014).Expert Opin Ther Pat. 2015;25(8):849-72. DM6FCS9 RU https://www.ncbi.nlm.nih.gov/pubmed/25991433 DM6FCS9 DI DM6FCS9 DM6FCS9 DN PMID25991433-Compound-P5 DM6FCS9 MI TT056SO DM6FCS9 MN Stress-activated protein kinase JNK3 (JNK3) DM6FCS9 MT DTT DM6FCS9 MA Inhibitor DM6FCS9 RN c-Jun N-terminal kinase inhibitors: a patent review (2010 - 2014).Expert Opin Ther Pat. 2015;25(8):849-72. DM6FCS9 RU https://www.ncbi.nlm.nih.gov/pubmed/25991433 DMNDVC9 DI DMNDVC9 DMNDVC9 DN PMID25991433-Compound-P6 DMNDVC9 MI TT0K6EO DMNDVC9 MN Stress-activated protein kinase JNK1 (JNK1) DMNDVC9 MT DTT DMNDVC9 MA Inhibitor DMNDVC9 RN c-Jun N-terminal kinase inhibitors: a patent review (2010 - 2014).Expert Opin Ther Pat. 2015;25(8):849-72. DMNDVC9 RU https://www.ncbi.nlm.nih.gov/pubmed/25991433 DMNDVC9 DI DMNDVC9 DMNDVC9 DN PMID25991433-Compound-P6 DMNDVC9 MI TTHS0U8 DMNDVC9 MN Stress-activated protein kinase JNK2 (JNK2) DMNDVC9 MT DTT DMNDVC9 MA Inhibitor DMNDVC9 RN c-Jun N-terminal kinase inhibitors: a patent review (2010 - 2014).Expert Opin Ther Pat. 2015;25(8):849-72. DMNDVC9 RU https://www.ncbi.nlm.nih.gov/pubmed/25991433 DMNDVC9 DI DMNDVC9 DMNDVC9 DN PMID25991433-Compound-P6 DMNDVC9 MI TT056SO DMNDVC9 MN Stress-activated protein kinase JNK3 (JNK3) DMNDVC9 MT DTT DMNDVC9 MA Inhibitor DMNDVC9 RN c-Jun N-terminal kinase inhibitors: a patent review (2010 - 2014).Expert Opin Ther Pat. 2015;25(8):849-72. DMNDVC9 RU https://www.ncbi.nlm.nih.gov/pubmed/25991433 DMEMSB2 DI DMEMSB2 DMEMSB2 DN PMID25991433-Compound-Q1 DMEMSB2 MI TTR2TXZ DMEMSB2 MN Jun N terminal kinase (JNK) DMEMSB2 MT DTT DMEMSB2 MA Inhibitor DMEMSB2 RN c-Jun N-terminal kinase inhibitors: a patent review (2010 - 2014).Expert Opin Ther Pat. 2015;25(8):849-72. DMEMSB2 RU https://www.ncbi.nlm.nih.gov/pubmed/25991433 DMEMSB2 DI DMEMSB2 DMEMSB2 DN PMID25991433-Compound-Q1 DMEMSB2 MI TTVOE6D DMEMSB2 MN Mitogen-activated protein kinase (MAPK) DMEMSB2 MT DTT DMEMSB2 MA Inhibitor DMEMSB2 RN c-Jun N-terminal kinase inhibitors: a patent review (2010 - 2014).Expert Opin Ther Pat. 2015;25(8):849-72. DMEMSB2 RU https://www.ncbi.nlm.nih.gov/pubmed/25991433 DMAIKJV DI DMAIKJV DMAIKJV DN PMID25991433-Compound-Q2 DMAIKJV MI TTVOE6D DMAIKJV MN Mitogen-activated protein kinase (MAPK) DMAIKJV MT DTT DMAIKJV MA Inhibitor DMAIKJV RN c-Jun N-terminal kinase inhibitors: a patent review (2010 - 2014).Expert Opin Ther Pat. 2015;25(8):849-72. DMAIKJV RU https://www.ncbi.nlm.nih.gov/pubmed/25991433 DM8FQJB DI DM8FQJB DM8FQJB DN PMID26004420-Compound-U2014S0288042A DM8FQJB MI TTJ13ST DM8FQJB MN Inward rectifier potassium channel Kir1.1 (KCNJ1) DM8FQJB MT DTT DM8FQJB MA Inhibitor DM8FQJB RN Inhibitors of the renal outer medullary potassium channel: a patent review.Expert Opin Ther Pat. 2015;25(9):1035-51. DM8FQJB RU https://www.ncbi.nlm.nih.gov/pubmed/26004420 DM8RJTQ DI DM8RJTQ DM8RJTQ DN PMID26004420-Compound-U2014S0288042C DM8RJTQ MI TTJ13ST DM8RJTQ MN Inward rectifier potassium channel Kir1.1 (KCNJ1) DM8RJTQ MT DTT DM8RJTQ MA Inhibitor DM8RJTQ RN Inhibitors of the renal outer medullary potassium channel: a patent review.Expert Opin Ther Pat. 2015;25(9):1035-51. DM8RJTQ RU https://www.ncbi.nlm.nih.gov/pubmed/26004420 DMVQSYT DI DMVQSYT DMVQSYT DN PMID26004420-Compound-US20140031349A DMVQSYT MI TTJ13ST DMVQSYT MN Inward rectifier potassium channel Kir1.1 (KCNJ1) DMVQSYT MT DTT DMVQSYT MA Inhibitor DMVQSYT RN Inhibitors of the renal outer medullary potassium channel: a patent review.Expert Opin Ther Pat. 2015;25(9):1035-51. DMVQSYT RU https://www.ncbi.nlm.nih.gov/pubmed/26004420 DM3M1NB DI DM3M1NB DM3M1NB DN PMID26004420-Compound-US20140031349B DM3M1NB MI TTJ13ST DM3M1NB MN Inward rectifier potassium channel Kir1.1 (KCNJ1) DM3M1NB MT DTT DM3M1NB MA Inhibitor DM3M1NB RN Inhibitors of the renal outer medullary potassium channel: a patent review.Expert Opin Ther Pat. 2015;25(9):1035-51. DM3M1NB RU https://www.ncbi.nlm.nih.gov/pubmed/26004420 DMDP8J0 DI DMDP8J0 DMDP8J0 DN PMID26004420-Compound-US20140031349C DMDP8J0 MI TTJ13ST DMDP8J0 MN Inward rectifier potassium channel Kir1.1 (KCNJ1) DMDP8J0 MT DTT DMDP8J0 MA Inhibitor DMDP8J0 RN Inhibitors of the renal outer medullary potassium channel: a patent review.Expert Opin Ther Pat. 2015;25(9):1035-51. DMDP8J0 RU https://www.ncbi.nlm.nih.gov/pubmed/26004420 DMUD7IB DI DMUD7IB DMUD7IB DN PMID26004420-Compound-US20140031349D DMUD7IB MI TTJ13ST DMUD7IB MN Inward rectifier potassium channel Kir1.1 (KCNJ1) DMUD7IB MT DTT DMUD7IB MA Inhibitor DMUD7IB RN Inhibitors of the renal outer medullary potassium channel: a patent review.Expert Opin Ther Pat. 2015;25(9):1035-51. DMUD7IB RU https://www.ncbi.nlm.nih.gov/pubmed/26004420 DMIXVNQ DI DMIXVNQ DMIXVNQ DN PMID26004420-Compound-US20140142115A DMIXVNQ MI TTJ13ST DMIXVNQ MN Inward rectifier potassium channel Kir1.1 (KCNJ1) DMIXVNQ MT DTT DMIXVNQ MA Inhibitor DMIXVNQ RN Inhibitors of the renal outer medullary potassium channel: a patent review.Expert Opin Ther Pat. 2015;25(9):1035-51. DMIXVNQ RU https://www.ncbi.nlm.nih.gov/pubmed/26004420 DM07DC6 DI DM07DC6 DM07DC6 DN PMID26004420-Compound-US20140142115B DM07DC6 MI TTJ13ST DM07DC6 MN Inward rectifier potassium channel Kir1.1 (KCNJ1) DM07DC6 MT DTT DM07DC6 MA Inhibitor DM07DC6 RN Inhibitors of the renal outer medullary potassium channel: a patent review.Expert Opin Ther Pat. 2015;25(9):1035-51. DM07DC6 RU https://www.ncbi.nlm.nih.gov/pubmed/26004420 DMQ7Z5F DI DMQ7Z5F DMQ7Z5F DN PMID26004420-Compound-US20140142115C DMQ7Z5F MI TTJ13ST DMQ7Z5F MN Inward rectifier potassium channel Kir1.1 (KCNJ1) DMQ7Z5F MT DTT DMQ7Z5F MA Inhibitor DMQ7Z5F RN Inhibitors of the renal outer medullary potassium channel: a patent review.Expert Opin Ther Pat. 2015;25(9):1035-51. DMQ7Z5F RU https://www.ncbi.nlm.nih.gov/pubmed/26004420 DMQ5AIT DI DMQ5AIT DMQ5AIT DN PMID26004420-Compound-US20140275020D DMQ5AIT MI TTJ13ST DMQ5AIT MN Inward rectifier potassium channel Kir1.1 (KCNJ1) DMQ5AIT MT DTT DMQ5AIT MA Inhibitor DMQ5AIT RN Inhibitors of the renal outer medullary potassium channel: a patent review.Expert Opin Ther Pat. 2015;25(9):1035-51. DMQ5AIT RU https://www.ncbi.nlm.nih.gov/pubmed/26004420 DMH7JKI DI DMH7JKI DMH7JKI DN PMID26004420-Compound-US20140275020E DMH7JKI MI TTJ13ST DMH7JKI MN Inward rectifier potassium channel Kir1.1 (KCNJ1) DMH7JKI MT DTT DMH7JKI MA Inhibitor DMH7JKI RN Inhibitors of the renal outer medullary potassium channel: a patent review.Expert Opin Ther Pat. 2015;25(9):1035-51. DMH7JKI RU https://www.ncbi.nlm.nih.gov/pubmed/26004420 DMH8M1D DI DMH8M1D DMH8M1D DN PMID26004420-Compound-US20140309213A DMH8M1D MI TTJ13ST DMH8M1D MN Inward rectifier potassium channel Kir1.1 (KCNJ1) DMH8M1D MT DTT DMH8M1D MA Inhibitor DMH8M1D RN Inhibitors of the renal outer medullary potassium channel: a patent review.Expert Opin Ther Pat. 2015;25(9):1035-51. DMH8M1D RU https://www.ncbi.nlm.nih.gov/pubmed/26004420 DM0P4TA DI DM0P4TA DM0P4TA DN PMID26004420-Compound-US20140309213B DM0P4TA MI TTJ13ST DM0P4TA MN Inward rectifier potassium channel Kir1.1 (KCNJ1) DM0P4TA MT DTT DM0P4TA MA Inhibitor DM0P4TA RN Inhibitors of the renal outer medullary potassium channel: a patent review.Expert Opin Ther Pat. 2015;25(9):1035-51. DM0P4TA RU https://www.ncbi.nlm.nih.gov/pubmed/26004420 DM4M2TU DI DM4M2TU DM4M2TU DN PMID26004420-Compound-US20140336177D DM4M2TU MI TTJ13ST DM4M2TU MN Inward rectifier potassium channel Kir1.1 (KCNJ1) DM4M2TU MT DTT DM4M2TU MA Inhibitor DM4M2TU RN Inhibitors of the renal outer medullary potassium channel: a patent review.Expert Opin Ther Pat. 2015;25(9):1035-51. DM4M2TU RU https://www.ncbi.nlm.nih.gov/pubmed/26004420 DMCRJO1 DI DMCRJO1 DMCRJO1 DN PMID26004420-Compound-US20140336177E DMCRJO1 MI TTJ13ST DMCRJO1 MN Inward rectifier potassium channel Kir1.1 (KCNJ1) DMCRJO1 MT DTT DMCRJO1 MA Inhibitor DMCRJO1 RN Inhibitors of the renal outer medullary potassium channel: a patent review.Expert Opin Ther Pat. 2015;25(9):1035-51. DMCRJO1 RU https://www.ncbi.nlm.nih.gov/pubmed/26004420 DM37GMQ DI DM37GMQ DM37GMQ DN PMID26004420-Compound-WO2010129379A DM37GMQ MI TTJ13ST DM37GMQ MN Inward rectifier potassium channel Kir1.1 (KCNJ1) DM37GMQ MT DTT DM37GMQ MA Inhibitor DM37GMQ RN Inhibitors of the renal outer medullary potassium channel: a patent review.Expert Opin Ther Pat. 2015;25(9):1035-51. DM37GMQ RU https://www.ncbi.nlm.nih.gov/pubmed/26004420 DM62A1H DI DM62A1H DM62A1H DN PMID26004420-Compound-WO2010129379B DM62A1H MI TTJ13ST DM62A1H MN Inward rectifier potassium channel Kir1.1 (KCNJ1) DM62A1H MT DTT DM62A1H MA Inhibitor DM62A1H RN Inhibitors of the renal outer medullary potassium channel: a patent review.Expert Opin Ther Pat. 2015;25(9):1035-51. DM62A1H RU https://www.ncbi.nlm.nih.gov/pubmed/26004420 DMV3X64 DI DMV3X64 DMV3X64 DN PMID26004420-Compound-WO2010129379C DMV3X64 MI TTJ13ST DMV3X64 MN Inward rectifier potassium channel Kir1.1 (KCNJ1) DMV3X64 MT DTT DMV3X64 MA Inhibitor DMV3X64 RN Inhibitors of the renal outer medullary potassium channel: a patent review.Expert Opin Ther Pat. 2015;25(9):1035-51. DMV3X64 RU https://www.ncbi.nlm.nih.gov/pubmed/26004420 DMR9B2D DI DMR9B2D DMR9B2D DN PMID26004420-Compound-WO2012058116A DMR9B2D MI TTJ13ST DMR9B2D MN Inward rectifier potassium channel Kir1.1 (KCNJ1) DMR9B2D MT DTT DMR9B2D MA Inhibitor DMR9B2D RN Inhibitors of the renal outer medullary potassium channel: a patent review.Expert Opin Ther Pat. 2015;25(9):1035-51. DMR9B2D RU https://www.ncbi.nlm.nih.gov/pubmed/26004420 DMD41UF DI DMD41UF DMD41UF DN PMID26004420-Compound-WO2012058116B DMD41UF MI TTJ13ST DMD41UF MN Inward rectifier potassium channel Kir1.1 (KCNJ1) DMD41UF MT DTT DMD41UF MA Inhibitor DMD41UF RN Inhibitors of the renal outer medullary potassium channel: a patent review.Expert Opin Ther Pat. 2015;25(9):1035-51. DMD41UF RU https://www.ncbi.nlm.nih.gov/pubmed/26004420 DM2Y64W DI DM2Y64W DM2Y64W DN PMID26004420-Compound-WO2012058116C DM2Y64W MI TTJ13ST DM2Y64W MN Inward rectifier potassium channel Kir1.1 (KCNJ1) DM2Y64W MT DTT DM2Y64W MA Inhibitor DM2Y64W RN Inhibitors of the renal outer medullary potassium channel: a patent review.Expert Opin Ther Pat. 2015;25(9):1035-51. DM2Y64W RU https://www.ncbi.nlm.nih.gov/pubmed/26004420 DMUX0SG DI DMUX0SG DMUX0SG DN PMID26004420-Compound-WO2012058134A DMUX0SG MI TTJ13ST DMUX0SG MN Inward rectifier potassium channel Kir1.1 (KCNJ1) DMUX0SG MT DTT DMUX0SG MA Inhibitor DMUX0SG RN Inhibitors of the renal outer medullary potassium channel: a patent review.Expert Opin Ther Pat. 2015;25(9):1035-51. DMUX0SG RU https://www.ncbi.nlm.nih.gov/pubmed/26004420 DMGVXCL DI DMGVXCL DMGVXCL DN PMID26004420-Compound-WO2012058134B DMGVXCL MI TTJ13ST DMGVXCL MN Inward rectifier potassium channel Kir1.1 (KCNJ1) DMGVXCL MT DTT DMGVXCL MA Inhibitor DMGVXCL RN Inhibitors of the renal outer medullary potassium channel: a patent review.Expert Opin Ther Pat. 2015;25(9):1035-51. DMGVXCL RU https://www.ncbi.nlm.nih.gov/pubmed/26004420 DM9AJVK DI DM9AJVK DM9AJVK DN PMID26004420-Compound-WO2012058134C DM9AJVK MI TTJ13ST DM9AJVK MN Inward rectifier potassium channel Kir1.1 (KCNJ1) DM9AJVK MT DTT DM9AJVK MA Inhibitor DM9AJVK RN Inhibitors of the renal outer medullary potassium channel: a patent review.Expert Opin Ther Pat. 2015;25(9):1035-51. DM9AJVK RU https://www.ncbi.nlm.nih.gov/pubmed/26004420 DMIV92A DI DMIV92A DMIV92A DN PMID26004420-Compound-WO2013028474A DMIV92A MI TTJ13ST DMIV92A MN Inward rectifier potassium channel Kir1.1 (KCNJ1) DMIV92A MT DTT DMIV92A MA Inhibitor DMIV92A RN Inhibitors of the renal outer medullary potassium channel: a patent review.Expert Opin Ther Pat. 2015;25(9):1035-51. DMIV92A RU https://www.ncbi.nlm.nih.gov/pubmed/26004420 DMCP0WF DI DMCP0WF DMCP0WF DN PMID26004420-Compound-WO2013028474B DMCP0WF MI TTJ13ST DMCP0WF MN Inward rectifier potassium channel Kir1.1 (KCNJ1) DMCP0WF MT DTT DMCP0WF MA Inhibitor DMCP0WF RN Inhibitors of the renal outer medullary potassium channel: a patent review.Expert Opin Ther Pat. 2015;25(9):1035-51. DMCP0WF RU https://www.ncbi.nlm.nih.gov/pubmed/26004420 DMTCPNY DI DMTCPNY DMTCPNY DN PMID26004420-Compound-WO2013028474C DMTCPNY MI TTJ13ST DMTCPNY MN Inward rectifier potassium channel Kir1.1 (KCNJ1) DMTCPNY MT DTT DMTCPNY MA Inhibitor DMTCPNY RN Inhibitors of the renal outer medullary potassium channel: a patent review.Expert Opin Ther Pat. 2015;25(9):1035-51. DMTCPNY RU https://www.ncbi.nlm.nih.gov/pubmed/26004420 DMT7GQ1 DI DMT7GQ1 DMT7GQ1 DN PMID26004420-Compound-WO2013039802A DMT7GQ1 MI TTJ13ST DMT7GQ1 MN Inward rectifier potassium channel Kir1.1 (KCNJ1) DMT7GQ1 MT DTT DMT7GQ1 MA Inhibitor DMT7GQ1 RN Inhibitors of the renal outer medullary potassium channel: a patent review.Expert Opin Ther Pat. 2015;25(9):1035-51. DMT7GQ1 RU https://www.ncbi.nlm.nih.gov/pubmed/26004420 DMP130R DI DMP130R DMP130R DN PMID26004420-Compound-WO2013039802B DMP130R MI TTJ13ST DMP130R MN Inward rectifier potassium channel Kir1.1 (KCNJ1) DMP130R MT DTT DMP130R MA Inhibitor DMP130R RN Inhibitors of the renal outer medullary potassium channel: a patent review.Expert Opin Ther Pat. 2015;25(9):1035-51. DMP130R RU https://www.ncbi.nlm.nih.gov/pubmed/26004420 DMV7ISR DI DMV7ISR DMV7ISR DN PMID26004420-Compound-WO2013039802C DMV7ISR MI TTJ13ST DMV7ISR MN Inward rectifier potassium channel Kir1.1 (KCNJ1) DMV7ISR MT DTT DMV7ISR MA Inhibitor DMV7ISR RN Inhibitors of the renal outer medullary potassium channel: a patent review.Expert Opin Ther Pat. 2015;25(9):1035-51. DMV7ISR RU https://www.ncbi.nlm.nih.gov/pubmed/26004420 DMH7E38 DI DMH7E38 DMH7E38 DN PMID26004420-Compound-WO2013062892D DMH7E38 MI TTJ13ST DMH7E38 MN Inward rectifier potassium channel Kir1.1 (KCNJ1) DMH7E38 MT DTT DMH7E38 MA Inhibitor DMH7E38 RN Inhibitors of the renal outer medullary potassium channel: a patent review.Expert Opin Ther Pat. 2015;25(9):1035-51. DMH7E38 RU https://www.ncbi.nlm.nih.gov/pubmed/26004420 DMMHLA9 DI DMMHLA9 DMMHLA9 DN PMID26004420-Compound-WO2013062892E DMMHLA9 MI TTJ13ST DMMHLA9 MN Inward rectifier potassium channel Kir1.1 (KCNJ1) DMMHLA9 MT DTT DMMHLA9 MA Inhibitor DMMHLA9 RN Inhibitors of the renal outer medullary potassium channel: a patent review.Expert Opin Ther Pat. 2015;25(9):1035-51. DMMHLA9 RU https://www.ncbi.nlm.nih.gov/pubmed/26004420 DM5N9M4 DI DM5N9M4 DM5N9M4 DN PMID26004420-Compound-WO2013062900A DM5N9M4 MI TTJ13ST DM5N9M4 MN Inward rectifier potassium channel Kir1.1 (KCNJ1) DM5N9M4 MT DTT DM5N9M4 MA Inhibitor DM5N9M4 RN Inhibitors of the renal outer medullary potassium channel: a patent review.Expert Opin Ther Pat. 2015;25(9):1035-51. DM5N9M4 RU https://www.ncbi.nlm.nih.gov/pubmed/26004420 DMIM8UF DI DMIM8UF DMIM8UF DN PMID26004420-Compound-WO2013062900B DMIM8UF MI TTJ13ST DMIM8UF MN Inward rectifier potassium channel Kir1.1 (KCNJ1) DMIM8UF MT DTT DMIM8UF MA Inhibitor DMIM8UF RN Inhibitors of the renal outer medullary potassium channel: a patent review.Expert Opin Ther Pat. 2015;25(9):1035-51. DMIM8UF RU https://www.ncbi.nlm.nih.gov/pubmed/26004420 DMDZHAB DI DMDZHAB DMDZHAB DN PMID26004420-Compound-WO2013062900C DMDZHAB MI TTJ13ST DMDZHAB MN Inward rectifier potassium channel Kir1.1 (KCNJ1) DMDZHAB MT DTT DMDZHAB MA Inhibitor DMDZHAB RN Inhibitors of the renal outer medullary potassium channel: a patent review.Expert Opin Ther Pat. 2015;25(9):1035-51. DMDZHAB RU https://www.ncbi.nlm.nih.gov/pubmed/26004420 DMRDUS9 DI DMRDUS9 DMRDUS9 DN PMID26004420-Compound-WO2014015495A DMRDUS9 MI TTJ13ST DMRDUS9 MN Inward rectifier potassium channel Kir1.1 (KCNJ1) DMRDUS9 MT DTT DMRDUS9 MA Inhibitor DMRDUS9 RN Inhibitors of the renal outer medullary potassium channel: a patent review.Expert Opin Ther Pat. 2015;25(9):1035-51. DMRDUS9 RU https://www.ncbi.nlm.nih.gov/pubmed/26004420 DMLH637 DI DMLH637 DMLH637 DN PMID26004420-Compound-WO2014015495B DMLH637 MI TTJ13ST DMLH637 MN Inward rectifier potassium channel Kir1.1 (KCNJ1) DMLH637 MT DTT DMLH637 MA Inhibitor DMLH637 RN Inhibitors of the renal outer medullary potassium channel: a patent review.Expert Opin Ther Pat. 2015;25(9):1035-51. DMLH637 RU https://www.ncbi.nlm.nih.gov/pubmed/26004420 DMHA18O DI DMHA18O DMHA18O DN PMID26004420-Compound-WO2014015495C DMHA18O MI TTJ13ST DMHA18O MN Inward rectifier potassium channel Kir1.1 (KCNJ1) DMHA18O MT DTT DMHA18O MA Inhibitor DMHA18O RN Inhibitors of the renal outer medullary potassium channel: a patent review.Expert Opin Ther Pat. 2015;25(9):1035-51. DMHA18O RU https://www.ncbi.nlm.nih.gov/pubmed/26004420 DM3QO5R DI DM3QO5R DM3QO5R DN PMID26004420-Compound-WO2014015495D DM3QO5R MI TTJ13ST DM3QO5R MN Inward rectifier potassium channel Kir1.1 (KCNJ1) DM3QO5R MT DTT DM3QO5R MA Inhibitor DM3QO5R RN Inhibitors of the renal outer medullary potassium channel: a patent review.Expert Opin Ther Pat. 2015;25(9):1035-51. DM3QO5R RU https://www.ncbi.nlm.nih.gov/pubmed/26004420 DMY6JAB DI DMY6JAB DMY6JAB DN PMID26004420-Compound-WO2014085210A DMY6JAB MI TTJ13ST DMY6JAB MN Inward rectifier potassium channel Kir1.1 (KCNJ1) DMY6JAB MT DTT DMY6JAB MA Inhibitor DMY6JAB RN Inhibitors of the renal outer medullary potassium channel: a patent review.Expert Opin Ther Pat. 2015;25(9):1035-51. DMY6JAB RU https://www.ncbi.nlm.nih.gov/pubmed/26004420 DMTD0RK DI DMTD0RK DMTD0RK DN PMID26004420-Compound-WO2014085210B DMTD0RK MI TTJ13ST DMTD0RK MN Inward rectifier potassium channel Kir1.1 (KCNJ1) DMTD0RK MT DTT DMTD0RK MA Inhibitor DMTD0RK RN Inhibitors of the renal outer medullary potassium channel: a patent review.Expert Opin Ther Pat. 2015;25(9):1035-51. DMTD0RK RU https://www.ncbi.nlm.nih.gov/pubmed/26004420 DMKC6SA DI DMKC6SA DMKC6SA DN PMID26004420-Compound-WO2014085210C DMKC6SA MI TTJ13ST DMKC6SA MN Inward rectifier potassium channel Kir1.1 (KCNJ1) DMKC6SA MT DTT DMKC6SA MA Inhibitor DMKC6SA RN Inhibitors of the renal outer medullary potassium channel: a patent review.Expert Opin Ther Pat. 2015;25(9):1035-51. DMKC6SA RU https://www.ncbi.nlm.nih.gov/pubmed/26004420 DMJIZWR DI DMJIZWR DMJIZWR DN PMID26004420-Compound-WO2014099633D DMJIZWR MI TTJ13ST DMJIZWR MN Inward rectifier potassium channel Kir1.1 (KCNJ1) DMJIZWR MT DTT DMJIZWR MA Inhibitor DMJIZWR RN Inhibitors of the renal outer medullary potassium channel: a patent review.Expert Opin Ther Pat. 2015;25(9):1035-51. DMJIZWR RU https://www.ncbi.nlm.nih.gov/pubmed/26004420 DMSPG8Y DI DMSPG8Y DMSPG8Y DN PMID26004420-Compound-WO2014099633E DMSPG8Y MI TTJ13ST DMSPG8Y MN Inward rectifier potassium channel Kir1.1 (KCNJ1) DMSPG8Y MT DTT DMSPG8Y MA Inhibitor DMSPG8Y RN Inhibitors of the renal outer medullary potassium channel: a patent review.Expert Opin Ther Pat. 2015;25(9):1035-51. DMSPG8Y RU https://www.ncbi.nlm.nih.gov/pubmed/26004420 DM59INV DI DM59INV DM59INV DN PMID26004420-Compound-WO2014126944A DM59INV MI TTJ13ST DM59INV MN Inward rectifier potassium channel Kir1.1 (KCNJ1) DM59INV MT DTT DM59INV MA Inhibitor DM59INV RN Inhibitors of the renal outer medullary potassium channel: a patent review.Expert Opin Ther Pat. 2015;25(9):1035-51. DM59INV RU https://www.ncbi.nlm.nih.gov/pubmed/26004420 DMH0LBI DI DMH0LBI DMH0LBI DN PMID26004420-Compound-WO2014126944B DMH0LBI MI TTJ13ST DMH0LBI MN Inward rectifier potassium channel Kir1.1 (KCNJ1) DMH0LBI MT DTT DMH0LBI MA Inhibitor DMH0LBI RN Inhibitors of the renal outer medullary potassium channel: a patent review.Expert Opin Ther Pat. 2015;25(9):1035-51. DMH0LBI RU https://www.ncbi.nlm.nih.gov/pubmed/26004420 DMN1B3F DI DMN1B3F DMN1B3F DN PMID26004420-Compound-WO2014150132A DMN1B3F MI TTJ13ST DMN1B3F MN Inward rectifier potassium channel Kir1.1 (KCNJ1) DMN1B3F MT DTT DMN1B3F MA Inhibitor DMN1B3F RN Inhibitors of the renal outer medullary potassium channel: a patent review.Expert Opin Ther Pat. 2015;25(9):1035-51. DMN1B3F RU https://www.ncbi.nlm.nih.gov/pubmed/26004420 DMJX8WY DI DMJX8WY DMJX8WY DN PMID26004420-Compound-WO2014150132B DMJX8WY MI TTJ13ST DMJX8WY MN Inward rectifier potassium channel Kir1.1 (KCNJ1) DMJX8WY MT DTT DMJX8WY MA Inhibitor DMJX8WY RN Inhibitors of the renal outer medullary potassium channel: a patent review.Expert Opin Ther Pat. 2015;25(9):1035-51. DMJX8WY RU https://www.ncbi.nlm.nih.gov/pubmed/26004420 DM2FDCT DI DM2FDCT DM2FDCT DN PMID26004420-Compound-WO2014150132C DM2FDCT MI TTJ13ST DM2FDCT MN Inward rectifier potassium channel Kir1.1 (KCNJ1) DM2FDCT MT DTT DM2FDCT MA Inhibitor DM2FDCT RN Inhibitors of the renal outer medullary potassium channel: a patent review.Expert Opin Ther Pat. 2015;25(9):1035-51. DM2FDCT RU https://www.ncbi.nlm.nih.gov/pubmed/26004420 DMI30GA DI DMI30GA DMI30GA DN PMID26004420-Compound-WO2015017305D DMI30GA MI TTJ13ST DMI30GA MN Inward rectifier potassium channel Kir1.1 (KCNJ1) DMI30GA MT DTT DMI30GA MA Inhibitor DMI30GA RN Inhibitors of the renal outer medullary potassium channel: a patent review.Expert Opin Ther Pat. 2015;25(9):1035-51. DMI30GA RU https://www.ncbi.nlm.nih.gov/pubmed/26004420 DMV4HQ5 DI DMV4HQ5 DMV4HQ5 DN PMID26004420-Compound-WO2015017305E DMV4HQ5 MI TTJ13ST DMV4HQ5 MN Inward rectifier potassium channel Kir1.1 (KCNJ1) DMV4HQ5 MT DTT DMV4HQ5 MA Inhibitor DMV4HQ5 RN Inhibitors of the renal outer medullary potassium channel: a patent review.Expert Opin Ther Pat. 2015;25(9):1035-51. DMV4HQ5 RU https://www.ncbi.nlm.nih.gov/pubmed/26004420 DMLV6IY DI DMLV6IY DMLV6IY DN PMID26004420-Compound-WO2015017305F DMLV6IY MI TTJ13ST DMLV6IY MN Inward rectifier potassium channel Kir1.1 (KCNJ1) DMLV6IY MT DTT DMLV6IY MA Inhibitor DMLV6IY RN Inhibitors of the renal outer medullary potassium channel: a patent review.Expert Opin Ther Pat. 2015;25(9):1035-51. DMLV6IY RU https://www.ncbi.nlm.nih.gov/pubmed/26004420 DMENX90 DI DMENX90 DMENX90 DN PMID26077642-Compound-Figure3A DMENX90 MI TTVSYP9 DMENX90 MN Ubiquitin carboxyl-terminal hydrolase 14 (USP14) DMENX90 MT DTT DMENX90 MA Inhibitor DMENX90 RN Deubiquitinases (DUBs) and DUB inhibitors: a patent review.Expert Opin Ther Pat. 2015;25(10):1191-1208. DMENX90 RU https://www.ncbi.nlm.nih.gov/pubmed/26077642 DMENX90 DI DMENX90 DMENX90 DN PMID26077642-Compound-Figure3A DMENX90 MI TTSX29Z DMENX90 MN Ubiquitin C-terminal hydrolase UCH37 (UCHL5) DMENX90 MT DTT DMENX90 MA Inhibitor DMENX90 RN Deubiquitinases (DUBs) and DUB inhibitors: a patent review.Expert Opin Ther Pat. 2015;25(10):1191-1208. DMENX90 RU https://www.ncbi.nlm.nih.gov/pubmed/26077642 DM9A8PN DI DM9A8PN DM9A8PN DN PMID26077642-Compound-Figure3G DM9A8PN MI TTZC0KV DM9A8PN MN Zinc finger-containing ubiquitin peptidase 1 (ZUP1) DM9A8PN MT DTT DM9A8PN MA Inhibitor DM9A8PN RN Deubiquitinases (DUBs) and DUB inhibitors: a patent review.Expert Opin Ther Pat. 2015;25(10):1191-1208. DM9A8PN RU https://www.ncbi.nlm.nih.gov/pubmed/26077642 DMQYWBR DI DMQYWBR DMQYWBR DN PMID26077642-Compound-Figure3H DMQYWBR MI TTZC0KV DMQYWBR MN Zinc finger-containing ubiquitin peptidase 1 (ZUP1) DMQYWBR MT DTT DMQYWBR MA Inhibitor DMQYWBR RN Deubiquitinases (DUBs) and DUB inhibitors: a patent review.Expert Opin Ther Pat. 2015;25(10):1191-1208. DMQYWBR RU https://www.ncbi.nlm.nih.gov/pubmed/26077642 DMS9KCF DI DMS9KCF DMS9KCF DN PMID26077642-Compound-Vif1 DMS9KCF MI TTXU3EQ DMS9KCF MN Herpesvirus ubiquitin-specific protease (HAUSP) DMS9KCF MT DTT DMS9KCF MA Inhibitor DMS9KCF RN Deubiquitinases (DUBs) and DUB inhibitors: a patent review.Expert Opin Ther Pat. 2015;25(10):1191-1208. DMS9KCF RU https://www.ncbi.nlm.nih.gov/pubmed/26077642 DMYXIS7 DI DMYXIS7 DMYXIS7 DN PMID26077642-Compound-Vif2 DMYXIS7 MI TTXU3EQ DMYXIS7 MN Herpesvirus ubiquitin-specific protease (HAUSP) DMYXIS7 MT DTT DMYXIS7 MA Inhibitor DMYXIS7 RN Deubiquitinases (DUBs) and DUB inhibitors: a patent review.Expert Opin Ther Pat. 2015;25(10):1191-1208. DMYXIS7 RU https://www.ncbi.nlm.nih.gov/pubmed/26077642 DM2PUBI DI DM2PUBI DM2PUBI DN PMID26099857-Compound-WO2011037610Formula(I) DM2PUBI MI TTKVTQO DM2PUBI MN Prostaglandin transporter (SLC21A2) DM2PUBI MT DTT DM2PUBI MA Inhibitor DM2PUBI RN Treatment of obesity and pulmonary arterial hypertension with inhibitors of the prostaglandin transporter: evaluation of patent WO2014/204895A1.Expert Opin Ther Pat. 2015;25(9):1069-77. DM2PUBI RU https://www.ncbi.nlm.nih.gov/pubmed/26099857 DMXVCHZ DI DMXVCHZ DMXVCHZ DN PMID26161698-Compound-10 DMXVCHZ MI TTMBO1Z DMXVCHZ MN Cyclin-dependent kinase (CDK) DMXVCHZ MT DTT DMXVCHZ MA Inhibitor DMXVCHZ RN Cyclin-dependent kinase inhibitors for cancer therapy: a patent review (2009 - 2014).Expert Opin Ther Pat. 2015;25(9):953-70. DMXVCHZ RU https://www.ncbi.nlm.nih.gov/pubmed/26161698 DMB92RA DI DMB92RA DMB92RA DN PMID26161698-Compound-17 DMB92RA MI TTMYWL7 DMB92RA MN Cyclin-dependent kinase 3 (CDK3) DMB92RA MT DTT DMB92RA MA Inhibitor DMB92RA RN Cyclin-dependent kinase inhibitors for cancer therapy: a patent review (2009 - 2014).Expert Opin Ther Pat. 2015;25(9):953-70. DMB92RA RU https://www.ncbi.nlm.nih.gov/pubmed/26161698 DMB92RA DI DMB92RA DMB92RA DN PMID26161698-Compound-17 DMB92RA MI TT0PG8F DMB92RA MN Cyclin-dependent kinase 4 (CDK4) DMB92RA MT DTT DMB92RA MA Inhibitor DMB92RA RN Cyclin-dependent kinase inhibitors for cancer therapy: a patent review (2009 - 2014).Expert Opin Ther Pat. 2015;25(9):953-70. DMB92RA RU https://www.ncbi.nlm.nih.gov/pubmed/26161698 DM6JVR5 DI DM6JVR5 DM6JVR5 DN PMID26161698-Compound-18 DM6JVR5 MI TTL4Q97 DM6JVR5 MN Cyclin-dependent kinase 5 (CDK5) DM6JVR5 MT DTT DM6JVR5 MA Inhibitor DM6JVR5 RN Cyclin-dependent kinase inhibitors for cancer therapy: a patent review (2009 - 2014).Expert Opin Ther Pat. 2015;25(9):953-70. DM6JVR5 RU https://www.ncbi.nlm.nih.gov/pubmed/26161698 DM6JVR5 DI DM6JVR5 DM6JVR5 DN PMID26161698-Compound-18 DM6JVR5 MI TTRSMW9 DM6JVR5 MN Glycogen synthase kinase-3 beta (GSK-3B) DM6JVR5 MT DTT DM6JVR5 MA Inhibitor DM6JVR5 RN Cyclin-dependent kinase inhibitors for cancer therapy: a patent review (2009 - 2014).Expert Opin Ther Pat. 2015;25(9):953-70. DM6JVR5 RU https://www.ncbi.nlm.nih.gov/pubmed/26161698 DM4AFHY DI DM4AFHY DM4AFHY DN PMID26161698-Compound-25 DM4AFHY MI TT7HF4W DM4AFHY MN Cyclin-dependent kinase 2 (CDK2) DM4AFHY MT DTT DM4AFHY MA Inhibitor DM4AFHY RN Cyclin-dependent kinase inhibitors for cancer therapy: a patent review (2009 - 2014).Expert Opin Ther Pat. 2015;25(9):953-70. DM4AFHY RU https://www.ncbi.nlm.nih.gov/pubmed/26161698 DM4AFHY DI DM4AFHY DM4AFHY DN PMID26161698-Compound-25 DM4AFHY MI TT1LVF2 DM4AFHY MN Cyclin-dependent kinase 9 (CDK9) DM4AFHY MT DTT DM4AFHY MA Inhibitor DM4AFHY RN Cyclin-dependent kinase inhibitors for cancer therapy: a patent review (2009 - 2014).Expert Opin Ther Pat. 2015;25(9):953-70. DM4AFHY RU https://www.ncbi.nlm.nih.gov/pubmed/26161698 DMRIWKV DI DMRIWKV DMRIWKV DN PMID26161698-Compound-32 DMRIWKV MI TT1LVF2 DMRIWKV MN Cyclin-dependent kinase 9 (CDK9) DMRIWKV MT DTT DMRIWKV MA Inhibitor DMRIWKV RN Cyclin-dependent kinase inhibitors for cancer therapy: a patent review (2009 - 2014).Expert Opin Ther Pat. 2015;25(9):953-70. DMRIWKV RU https://www.ncbi.nlm.nih.gov/pubmed/26161698 DMTIM1E DI DMTIM1E DMTIM1E DN PMID26161698-Compound-34 DMTIM1E MI TTQYF7G DMTIM1E MN Cyclin-dependent kinase 7 (CDK7) DMTIM1E MT DTT DMTIM1E MA Inhibitor DMTIM1E RN Cyclin-dependent kinase inhibitors for cancer therapy: a patent review (2009 - 2014).Expert Opin Ther Pat. 2015;25(9):953-70. DMTIM1E RU https://www.ncbi.nlm.nih.gov/pubmed/26161698 DM8UPO3 DI DM8UPO3 DM8UPO3 DN PMID26161698-Compound-44 DM8UPO3 MI TTSMTDI DM8UPO3 MN CDC7-related kinase (CDC7) DM8UPO3 MT DTT DM8UPO3 MA Inhibitor DM8UPO3 RN Cyclin-dependent kinase inhibitors for cancer therapy: a patent review (2009 - 2014).Expert Opin Ther Pat. 2015;25(9):953-70. DM8UPO3 RU https://www.ncbi.nlm.nih.gov/pubmed/26161698 DM8UPO3 DI DM8UPO3 DM8UPO3 DN PMID26161698-Compound-44 DM8UPO3 MI TTMBO1Z DM8UPO3 MN Cyclin-dependent kinase (CDK) DM8UPO3 MT DTT DM8UPO3 MA Inhibitor DM8UPO3 RN Cyclin-dependent kinase inhibitors for cancer therapy: a patent review (2009 - 2014).Expert Opin Ther Pat. 2015;25(9):953-70. DM8UPO3 RU https://www.ncbi.nlm.nih.gov/pubmed/26161698 DMF9C4I DI DMF9C4I DMF9C4I DN PMID26161824-Compound-68 DMF9C4I MI TT6OEDT DMF9C4I MN Cannabinoid receptor 1 (CB1) DMF9C4I MT DTT DMF9C4I MA Antagonist DMF9C4I RN A comprehensive patents review on cannabinoid 1 receptor antagonists as antiobesity agents. Expert Opin Ther Pat. 2015 Oct;25(10):1093-116. DMF9C4I RU https://pubmed.ncbi.nlm.nih.gov/26161824 DMKOSN5 DI DMKOSN5 DMKOSN5 DN PMID26161824-Compound-69 DMKOSN5 MI TT6OEDT DMKOSN5 MN Cannabinoid receptor 1 (CB1) DMKOSN5 MT DTT DMKOSN5 MA Antagonist DMKOSN5 RN A comprehensive patents review on cannabinoid 1 receptor antagonists as antiobesity agents. Expert Opin Ther Pat. 2015 Oct;25(10):1093-116. DMKOSN5 RU https://pubmed.ncbi.nlm.nih.gov/26161824 DMHXT12 DI DMHXT12 DMHXT12 DN PMID26293650-Compound-34 DMHXT12 MI TTH5TC2 DMHXT12 MN NF-kappa-B-activating kinase (TBK1) DMHXT12 MT DTT DMHXT12 MA Inhibitor DMHXT12 RN TBK1 inhibitors: a review of patent literature (2011 - 2014).Expert Opin Ther Pat. 2015;25(12):1385-96. DMHXT12 RU https://www.ncbi.nlm.nih.gov/pubmed/26293650 DMPG8MF DI DMPG8MF DMPG8MF DN PMID26293650-Compound-35 DMPG8MF MI TTH5TC2 DMPG8MF MN NF-kappa-B-activating kinase (TBK1) DMPG8MF MT DTT DMPG8MF MA Inhibitor DMPG8MF RN TBK1 inhibitors: a review of patent literature (2011 - 2014).Expert Opin Ther Pat. 2015;25(12):1385-96. DMPG8MF RU https://www.ncbi.nlm.nih.gov/pubmed/26293650 DMP8RQ4 DI DMP8RQ4 DMP8RQ4 DN PMID26394986-Compound-10 DMP8RQ4 MI TTN7R6K DMP8RQ4 MN Signal transducer and activator of transcription 1 (STAT1) DMP8RQ4 MT DTT DMP8RQ4 MA Inhibitor DMP8RQ4 RN A STAT inhibitor patent review: progress since 2011.Expert Opin Ther Pat. 2015;25(12):1397-421. DMP8RQ4 RU https://www.ncbi.nlm.nih.gov/pubmed/26394986 DMP8RQ4 DI DMP8RQ4 DMP8RQ4 DN PMID26394986-Compound-10 DMP8RQ4 MI TTH8FZW DMP8RQ4 MN Signal transducer and activator of transcription 3 (STAT3) DMP8RQ4 MT DTT DMP8RQ4 MA Inhibitor DMP8RQ4 RN A STAT inhibitor patent review: progress since 2011.Expert Opin Ther Pat. 2015;25(12):1397-421. DMP8RQ4 RU https://www.ncbi.nlm.nih.gov/pubmed/26394986 DMP8RQ4 DI DMP8RQ4 DMP8RQ4 DN PMID26394986-Compound-10 DMP8RQ4 MI TTLRFIH DMP8RQ4 MN Signal transducer and activator of transcription 5 (STAT5) DMP8RQ4 MT DTT DMP8RQ4 MA Inhibitor DMP8RQ4 RN A STAT inhibitor patent review: progress since 2011.Expert Opin Ther Pat. 2015;25(12):1397-421. DMP8RQ4 RU https://www.ncbi.nlm.nih.gov/pubmed/26394986 DMWMZE4 DI DMWMZE4 DMWMZE4 DN PMID26394986-Compound-11 DMWMZE4 MI TTH8FZW DMWMZE4 MN Signal transducer and activator of transcription 3 (STAT3) DMWMZE4 MT DTT DMWMZE4 MA Inhibitor DMWMZE4 RN A STAT inhibitor patent review: progress since 2011.Expert Opin Ther Pat. 2015;25(12):1397-421. DMWMZE4 RU https://www.ncbi.nlm.nih.gov/pubmed/26394986 DMTSQXE DI DMTSQXE DMTSQXE DN PMID26394986-Compound-12 DMTSQXE MI TTH8FZW DMTSQXE MN Signal transducer and activator of transcription 3 (STAT3) DMTSQXE MT DTT DMTSQXE MA Inhibitor DMTSQXE RN A STAT inhibitor patent review: progress since 2011.Expert Opin Ther Pat. 2015;25(12):1397-421. DMTSQXE RU https://www.ncbi.nlm.nih.gov/pubmed/26394986 DMBUZHO DI DMBUZHO DMBUZHO DN PMID26394986-Compound-13 DMBUZHO MI TTH8FZW DMBUZHO MN Signal transducer and activator of transcription 3 (STAT3) DMBUZHO MT DTT DMBUZHO MA Inhibitor DMBUZHO RN A STAT inhibitor patent review: progress since 2011.Expert Opin Ther Pat. 2015;25(12):1397-421. DMBUZHO RU https://www.ncbi.nlm.nih.gov/pubmed/26394986 DMF9J0Y DI DMF9J0Y DMF9J0Y DN PMID26394986-Compound-20 DMF9J0Y MI TTH8FZW DMF9J0Y MN Signal transducer and activator of transcription 3 (STAT3) DMF9J0Y MT DTT DMF9J0Y MA Inhibitor DMF9J0Y RN A STAT inhibitor patent review: progress since 2011.Expert Opin Ther Pat. 2015;25(12):1397-421. DMF9J0Y RU https://www.ncbi.nlm.nih.gov/pubmed/26394986 DMLMQD4 DI DMLMQD4 DMLMQD4 DN PMID26394986-Compound-21 DMLMQD4 MI TTH8FZW DMLMQD4 MN Signal transducer and activator of transcription 3 (STAT3) DMLMQD4 MT DTT DMLMQD4 MA Inhibitor DMLMQD4 RN A STAT inhibitor patent review: progress since 2011.Expert Opin Ther Pat. 2015;25(12):1397-421. DMLMQD4 RU https://www.ncbi.nlm.nih.gov/pubmed/26394986 DM43Z1G DI DM43Z1G DM43Z1G DN PMID26394986-Compound-22 DM43Z1G MI TTH8FZW DM43Z1G MN Signal transducer and activator of transcription 3 (STAT3) DM43Z1G MT DTT DM43Z1G MA Inhibitor DM43Z1G RN A STAT inhibitor patent review: progress since 2011.Expert Opin Ther Pat. 2015;25(12):1397-421. DM43Z1G RU https://www.ncbi.nlm.nih.gov/pubmed/26394986 DM2E6M7 DI DM2E6M7 DM2E6M7 DN PMID26394986-Compound-42 DM2E6M7 MI TTH8FZW DM2E6M7 MN Signal transducer and activator of transcription 3 (STAT3) DM2E6M7 MT DTT DM2E6M7 MA Inhibitor DM2E6M7 RN A STAT inhibitor patent review: progress since 2011.Expert Opin Ther Pat. 2015;25(12):1397-421. DM2E6M7 RU https://www.ncbi.nlm.nih.gov/pubmed/26394986 DM1HIEZ DI DM1HIEZ DM1HIEZ DN PMID26394986-Compound-43 DM1HIEZ MI TTH8FZW DM1HIEZ MN Signal transducer and activator of transcription 3 (STAT3) DM1HIEZ MT DTT DM1HIEZ MA Inhibitor DM1HIEZ RN A STAT inhibitor patent review: progress since 2011.Expert Opin Ther Pat. 2015;25(12):1397-421. DM1HIEZ RU https://www.ncbi.nlm.nih.gov/pubmed/26394986 DMOJ52P DI DMOJ52P DMOJ52P DN PMID26394986-Compound-44 DMOJ52P MI TTH8FZW DMOJ52P MN Signal transducer and activator of transcription 3 (STAT3) DMOJ52P MT DTT DMOJ52P MA Inhibitor DMOJ52P RN A STAT inhibitor patent review: progress since 2011.Expert Opin Ther Pat. 2015;25(12):1397-421. DMOJ52P RU https://www.ncbi.nlm.nih.gov/pubmed/26394986 DML5I9K DI DML5I9K DML5I9K DN PMID26394986-Compound-50 DML5I9K MI TTH8FZW DML5I9K MN Signal transducer and activator of transcription 3 (STAT3) DML5I9K MT DTT DML5I9K MA Inhibitor DML5I9K RN A STAT inhibitor patent review: progress since 2011.Expert Opin Ther Pat. 2015;25(12):1397-421. DML5I9K RU https://www.ncbi.nlm.nih.gov/pubmed/26394986 DMV6GIC DI DMV6GIC DMV6GIC DN PMID26394986-Compound-51 DMV6GIC MI TTH8FZW DMV6GIC MN Signal transducer and activator of transcription 3 (STAT3) DMV6GIC MT DTT DMV6GIC MA Inhibitor DMV6GIC RN A STAT inhibitor patent review: progress since 2011.Expert Opin Ther Pat. 2015;25(12):1397-421. DMV6GIC RU https://www.ncbi.nlm.nih.gov/pubmed/26394986 DMSZWAM DI DMSZWAM DMSZWAM DN PMID26394986-Compound-52 DMSZWAM MI TTH8FZW DMSZWAM MN Signal transducer and activator of transcription 3 (STAT3) DMSZWAM MT DTT DMSZWAM MA Inhibitor DMSZWAM RN A STAT inhibitor patent review: progress since 2011.Expert Opin Ther Pat. 2015;25(12):1397-421. DMSZWAM RU https://www.ncbi.nlm.nih.gov/pubmed/26394986 DMS6EDU DI DMS6EDU DMS6EDU DN PMID26394986-Compound-53 DMS6EDU MI TTH8FZW DMS6EDU MN Signal transducer and activator of transcription 3 (STAT3) DMS6EDU MT DTT DMS6EDU MA Inhibitor DMS6EDU RN A STAT inhibitor patent review: progress since 2011.Expert Opin Ther Pat. 2015;25(12):1397-421. DMS6EDU RU https://www.ncbi.nlm.nih.gov/pubmed/26394986 DMY8FZA DI DMY8FZA DMY8FZA DN PMID26394986-Compound-54 DMY8FZA MI TTH8FZW DMY8FZA MN Signal transducer and activator of transcription 3 (STAT3) DMY8FZA MT DTT DMY8FZA MA Inhibitor DMY8FZA RN A STAT inhibitor patent review: progress since 2011.Expert Opin Ther Pat. 2015;25(12):1397-421. DMY8FZA RU https://www.ncbi.nlm.nih.gov/pubmed/26394986 DMPNJ4X DI DMPNJ4X DMPNJ4X DN PMID26394986-Compound-56 DMPNJ4X MI TTLRFIH DMPNJ4X MN Signal transducer and activator of transcription 5 (STAT5) DMPNJ4X MT DTT DMPNJ4X MA Inhibitor DMPNJ4X RN A STAT inhibitor patent review: progress since 2011.Expert Opin Ther Pat. 2015;25(12):1397-421. DMPNJ4X RU https://www.ncbi.nlm.nih.gov/pubmed/26394986 DMILUT8 DI DMILUT8 DMILUT8 DN PMID26394986-Compound-57 DMILUT8 MI TTLRFIH DMILUT8 MN Signal transducer and activator of transcription 5 (STAT5) DMILUT8 MT DTT DMILUT8 MA Inhibitor DMILUT8 RN A STAT inhibitor patent review: progress since 2011.Expert Opin Ther Pat. 2015;25(12):1397-421. DMILUT8 RU https://www.ncbi.nlm.nih.gov/pubmed/26394986 DMNEGA0 DI DMNEGA0 DMNEGA0 DN PMID26394986-Compound-Figure16 DMNEGA0 MI TTH8FZW DMNEGA0 MN Signal transducer and activator of transcription 3 (STAT3) DMNEGA0 MT DTT DMNEGA0 MA Inhibitor DMNEGA0 RN A STAT inhibitor patent review: progress since 2011.Expert Opin Ther Pat. 2015;25(12):1397-421. DMNEGA0 RU https://www.ncbi.nlm.nih.gov/pubmed/26394986 DMEGBHP DI DMEGBHP DMEGBHP DN PMID26394986-Compound-Figure17 DMEGBHP MI TTH8FZW DMEGBHP MN Signal transducer and activator of transcription 3 (STAT3) DMEGBHP MT DTT DMEGBHP MA Inhibitor DMEGBHP RN A STAT inhibitor patent review: progress since 2011.Expert Opin Ther Pat. 2015;25(12):1397-421. DMEGBHP RU https://www.ncbi.nlm.nih.gov/pubmed/26394986 DMNOJGW DI DMNOJGW DMNOJGW DN PMID26413912-Compound-84 DMNOJGW MI TTDP1UC DMNOJGW MN Fatty acid amide hydrolase (FAAH) DMNOJGW MT DTT DMNOJGW MA Inhibitor DMNOJGW RN Fatty acid amide hydrolase inhibitors: a patent review (2009-2014).Expert Opin Ther Pat. 2015;25(11):1247-66. DMNOJGW RU https://www.ncbi.nlm.nih.gov/pubmed/26413912 DMNOJGW DI DMNOJGW DMNOJGW DN PMID26413912-Compound-84 DMNOJGW MI TTGX13H DMNOJGW MN Fatty-acid amide hydrolase 1 (FAAH1) DMNOJGW MT DTT DMNOJGW MA Inhibitor DMNOJGW RN Fatty acid amide hydrolase inhibitors: a patent review (2009-2014).Expert Opin Ther Pat. 2015;25(11):1247-66. DMNOJGW RU https://www.ncbi.nlm.nih.gov/pubmed/26413912 DM9V13U DI DM9V13U DM9V13U DN PMID26560362-Compound-90 DM9V13U MI TTN9T81 DM9V13U MN Arachidonate 15-lipoxygenase (15-LOX) DM9V13U MT DTT DM9V13U MA Inhibitor DM9V13U RN 15-Lipoxygenase inhibitors: a patent review.Expert Opin Ther Pat. 2016;26(1):65-88. DM9V13U RU https://www.ncbi.nlm.nih.gov/pubmed/26560362 DMSI7F2 DI DMSI7F2 DMSI7F2 DN PMID26560530-Compound-1 DMSI7F2 MI TT2F4OL DMSI7F2 MN Tissue transglutaminase (TG2) DMSI7F2 MT DTT DMSI7F2 MA Inhibitor DMSI7F2 RN Transglutaminase inhibitors: a patent review.Expert Opin Ther Pat. 2016;26(1):49-63. DMSI7F2 RU https://www.ncbi.nlm.nih.gov/pubmed/26560530 DMZ5UST DI DMZ5UST DMZ5UST DN PMID26560530-Compound-11 DMZ5UST MI TT2F4OL DMZ5UST MN Tissue transglutaminase (TG2) DMZ5UST MT DTT DMZ5UST MA Inhibitor DMZ5UST RN Transglutaminase inhibitors: a patent review.Expert Opin Ther Pat. 2016;26(1):49-63. DMZ5UST RU https://www.ncbi.nlm.nih.gov/pubmed/26560530 DMA8JGP DI DMA8JGP DMA8JGP DN PMID26560530-Compound-12 DMA8JGP MI TT2F4OL DMA8JGP MN Tissue transglutaminase (TG2) DMA8JGP MT DTT DMA8JGP MA Inhibitor DMA8JGP RN Transglutaminase inhibitors: a patent review.Expert Opin Ther Pat. 2016;26(1):49-63. DMA8JGP RU https://www.ncbi.nlm.nih.gov/pubmed/26560530 DMKF26Z DI DMKF26Z DMKF26Z DN PMID26560530-Compound-13 DMKF26Z MI TTXI2RA DMKF26Z MN Coagulation factor XIIIA (F13A1) DMKF26Z MT DTT DMKF26Z MA Inhibitor DMKF26Z RN Transglutaminase inhibitors: a patent review.Expert Opin Ther Pat. 2016;26(1):49-63. DMKF26Z RU https://www.ncbi.nlm.nih.gov/pubmed/26560530 DMKF26Z DI DMKF26Z DMKF26Z DN PMID26560530-Compound-13 DMKF26Z MI TT2F4OL DMKF26Z MN Tissue transglutaminase (TG2) DMKF26Z MT DTT DMKF26Z MA Inhibitor DMKF26Z RN Transglutaminase inhibitors: a patent review.Expert Opin Ther Pat. 2016;26(1):49-63. DMKF26Z RU https://www.ncbi.nlm.nih.gov/pubmed/26560530 DM52MIK DI DM52MIK DM52MIK DN PMID26560530-Compound-14 DM52MIK MI TT2F4OL DM52MIK MN Tissue transglutaminase (TG2) DM52MIK MT DTT DM52MIK MA Inhibitor DM52MIK RN Transglutaminase inhibitors: a patent review.Expert Opin Ther Pat. 2016;26(1):49-63. DM52MIK RU https://www.ncbi.nlm.nih.gov/pubmed/26560530 DM1ZSEI DI DM1ZSEI DM1ZSEI DN PMID26560530-Compound-15 DM1ZSEI MI TT2F4OL DM1ZSEI MN Tissue transglutaminase (TG2) DM1ZSEI MT DTT DM1ZSEI MA Inhibitor DM1ZSEI RN Transglutaminase inhibitors: a patent review.Expert Opin Ther Pat. 2016;26(1):49-63. DM1ZSEI RU https://www.ncbi.nlm.nih.gov/pubmed/26560530 DM8UI4Z DI DM8UI4Z DM8UI4Z DN PMID26560530-Compound-16 DM8UI4Z MI TT2F4OL DM8UI4Z MN Tissue transglutaminase (TG2) DM8UI4Z MT DTT DM8UI4Z MA Inhibitor DM8UI4Z RN Transglutaminase inhibitors: a patent review.Expert Opin Ther Pat. 2016;26(1):49-63. DM8UI4Z RU https://www.ncbi.nlm.nih.gov/pubmed/26560530 DMITU83 DI DMITU83 DMITU83 DN PMID26560530-Compound-17 DMITU83 MI TT2F4OL DMITU83 MN Tissue transglutaminase (TG2) DMITU83 MT DTT DMITU83 MA Inhibitor DMITU83 RN Transglutaminase inhibitors: a patent review.Expert Opin Ther Pat. 2016;26(1):49-63. DMITU83 RU https://www.ncbi.nlm.nih.gov/pubmed/26560530 DMK39S5 DI DMK39S5 DMK39S5 DN PMID26560530-Compound-18 DMK39S5 MI TT2F4OL DMK39S5 MN Tissue transglutaminase (TG2) DMK39S5 MT DTT DMK39S5 MA Inhibitor DMK39S5 RN Transglutaminase inhibitors: a patent review.Expert Opin Ther Pat. 2016;26(1):49-63. DMK39S5 RU https://www.ncbi.nlm.nih.gov/pubmed/26560530 DMC7AXQ DI DMC7AXQ DMC7AXQ DN PMID26560530-Compound-2 DMC7AXQ MI TT2F4OL DMC7AXQ MN Tissue transglutaminase (TG2) DMC7AXQ MT DTT DMC7AXQ MA Inhibitor DMC7AXQ RN Transglutaminase inhibitors: a patent review.Expert Opin Ther Pat. 2016;26(1):49-63. DMC7AXQ RU https://www.ncbi.nlm.nih.gov/pubmed/26560530 DMDS2CU DI DMDS2CU DMDS2CU DN PMID26560530-Compound-23 DMDS2CU MI TT2F4OL DMDS2CU MN Tissue transglutaminase (TG2) DMDS2CU MT DTT DMDS2CU MA Inhibitor DMDS2CU RN Transglutaminase inhibitors: a patent review.Expert Opin Ther Pat. 2016;26(1):49-63. DMDS2CU RU https://www.ncbi.nlm.nih.gov/pubmed/26560530 DMWCM2I DI DMWCM2I DMWCM2I DN PMID26560530-Compound-24 DMWCM2I MI TT2F4OL DMWCM2I MN Tissue transglutaminase (TG2) DMWCM2I MT DTT DMWCM2I MA Inhibitor DMWCM2I RN Transglutaminase inhibitors: a patent review.Expert Opin Ther Pat. 2016;26(1):49-63. DMWCM2I RU https://www.ncbi.nlm.nih.gov/pubmed/26560530 DMZ43OM DI DMZ43OM DMZ43OM DN PMID26560530-Compound-25 DMZ43OM MI TT2F4OL DMZ43OM MN Tissue transglutaminase (TG2) DMZ43OM MT DTT DMZ43OM MA Inhibitor DMZ43OM RN Transglutaminase inhibitors: a patent review.Expert Opin Ther Pat. 2016;26(1):49-63. DMZ43OM RU https://www.ncbi.nlm.nih.gov/pubmed/26560530 DMVEQ2P DI DMVEQ2P DMVEQ2P DN PMID26560530-Compound-26 DMVEQ2P MI TT2F4OL DMVEQ2P MN Tissue transglutaminase (TG2) DMVEQ2P MT DTT DMVEQ2P MA Inhibitor DMVEQ2P RN Transglutaminase inhibitors: a patent review.Expert Opin Ther Pat. 2016;26(1):49-63. DMVEQ2P RU https://www.ncbi.nlm.nih.gov/pubmed/26560530 DM8WP3D DI DM8WP3D DM8WP3D DN PMID26560530-Compound-27 DM8WP3D MI TT2F4OL DM8WP3D MN Tissue transglutaminase (TG2) DM8WP3D MT DTT DM8WP3D MA Inhibitor DM8WP3D RN Transglutaminase inhibitors: a patent review.Expert Opin Ther Pat. 2016;26(1):49-63. DM8WP3D RU https://www.ncbi.nlm.nih.gov/pubmed/26560530 DM92OT0 DI DM92OT0 DM92OT0 DN PMID26560530-Compound-3 DM92OT0 MI TT2F4OL DM92OT0 MN Tissue transglutaminase (TG2) DM92OT0 MT DTT DM92OT0 MA Inhibitor DM92OT0 RN Transglutaminase inhibitors: a patent review.Expert Opin Ther Pat. 2016;26(1):49-63. DM92OT0 RU https://www.ncbi.nlm.nih.gov/pubmed/26560530 DM74GUB DI DM74GUB DM74GUB DN PMID26560530-Compound-31 DM74GUB MI TT2F4OL DM74GUB MN Tissue transglutaminase (TG2) DM74GUB MT DTT DM74GUB MA Inhibitor DM74GUB RN Transglutaminase inhibitors: a patent review.Expert Opin Ther Pat. 2016;26(1):49-63. DM74GUB RU https://www.ncbi.nlm.nih.gov/pubmed/26560530 DM2QWXF DI DM2QWXF DM2QWXF DN PMID26560530-Compound-32 DM2QWXF MI TT2F4OL DM2QWXF MN Tissue transglutaminase (TG2) DM2QWXF MT DTT DM2QWXF MA Inhibitor DM2QWXF RN Transglutaminase inhibitors: a patent review.Expert Opin Ther Pat. 2016;26(1):49-63. DM2QWXF RU https://www.ncbi.nlm.nih.gov/pubmed/26560530 DMUL84D DI DMUL84D DMUL84D DN PMID26560530-Compound-33 DMUL84D MI TT2F4OL DMUL84D MN Tissue transglutaminase (TG2) DMUL84D MT DTT DMUL84D MA Inhibitor DMUL84D RN Transglutaminase inhibitors: a patent review.Expert Opin Ther Pat. 2016;26(1):49-63. DMUL84D RU https://www.ncbi.nlm.nih.gov/pubmed/26560530 DMLGZPO DI DMLGZPO DMLGZPO DN PMID26560530-Compound-34 DMLGZPO MI TT2F4OL DMLGZPO MN Tissue transglutaminase (TG2) DMLGZPO MT DTT DMLGZPO MA Inhibitor DMLGZPO RN Transglutaminase inhibitors: a patent review.Expert Opin Ther Pat. 2016;26(1):49-63. DMLGZPO RU https://www.ncbi.nlm.nih.gov/pubmed/26560530 DMO36RL DI DMO36RL DMO36RL DN PMID26560530-Compound-35 DMO36RL MI TT2F4OL DMO36RL MN Tissue transglutaminase (TG2) DMO36RL MT DTT DMO36RL MA Inhibitor DMO36RL RN Transglutaminase inhibitors: a patent review.Expert Opin Ther Pat. 2016;26(1):49-63. DMO36RL RU https://www.ncbi.nlm.nih.gov/pubmed/26560530 DMEZLBQ DI DMEZLBQ DMEZLBQ DN PMID26560530-Compound-4 DMEZLBQ MI TT2F4OL DMEZLBQ MN Tissue transglutaminase (TG2) DMEZLBQ MT DTT DMEZLBQ MA Inhibitor DMEZLBQ RN Transglutaminase inhibitors: a patent review.Expert Opin Ther Pat. 2016;26(1):49-63. DMEZLBQ RU https://www.ncbi.nlm.nih.gov/pubmed/26560530 DMTOJCG DI DMTOJCG DMTOJCG DN PMID26560530-Compound-46 DMTOJCG MI TT2F4OL DMTOJCG MN Tissue transglutaminase (TG2) DMTOJCG MT DTT DMTOJCG MA Inhibitor DMTOJCG RN Transglutaminase inhibitors: a patent review.Expert Opin Ther Pat. 2016;26(1):49-63. DMTOJCG RU https://www.ncbi.nlm.nih.gov/pubmed/26560530 DMWC1IY DI DMWC1IY DMWC1IY DN PMID26560530-Compound-47 DMWC1IY MI TT2F4OL DMWC1IY MN Tissue transglutaminase (TG2) DMWC1IY MT DTT DMWC1IY MA Inhibitor DMWC1IY RN Transglutaminase inhibitors: a patent review.Expert Opin Ther Pat. 2016;26(1):49-63. DMWC1IY RU https://www.ncbi.nlm.nih.gov/pubmed/26560530 DMXV0CK DI DMXV0CK DMXV0CK DN PMID26560530-Compound-48 DMXV0CK MI TT2F4OL DMXV0CK MN Tissue transglutaminase (TG2) DMXV0CK MT DTT DMXV0CK MA Inhibitor DMXV0CK RN Transglutaminase inhibitors: a patent review.Expert Opin Ther Pat. 2016;26(1):49-63. DMXV0CK RU https://www.ncbi.nlm.nih.gov/pubmed/26560530 DMST6C2 DI DMST6C2 DMST6C2 DN PMID26560530-Compound-49 DMST6C2 MI TT2F4OL DMST6C2 MN Tissue transglutaminase (TG2) DMST6C2 MT DTT DMST6C2 MA Inhibitor DMST6C2 RN Transglutaminase inhibitors: a patent review.Expert Opin Ther Pat. 2016;26(1):49-63. DMST6C2 RU https://www.ncbi.nlm.nih.gov/pubmed/26560530 DM6G2WJ DI DM6G2WJ DM6G2WJ DN PMID26560530-Compound-5 DM6G2WJ MI TT2F4OL DM6G2WJ MN Tissue transglutaminase (TG2) DM6G2WJ MT DTT DM6G2WJ MA Inhibitor DM6G2WJ RN Transglutaminase inhibitors: a patent review.Expert Opin Ther Pat. 2016;26(1):49-63. DM6G2WJ RU https://www.ncbi.nlm.nih.gov/pubmed/26560530 DMHZ8N1 DI DMHZ8N1 DMHZ8N1 DN PMID26560530-Compound-50 DMHZ8N1 MI TT2F4OL DMHZ8N1 MN Tissue transglutaminase (TG2) DMHZ8N1 MT DTT DMHZ8N1 MA Inhibitor DMHZ8N1 RN Transglutaminase inhibitors: a patent review.Expert Opin Ther Pat. 2016;26(1):49-63. DMHZ8N1 RU https://www.ncbi.nlm.nih.gov/pubmed/26560530 DM2X4R0 DI DM2X4R0 DM2X4R0 DN PMID26560530-Compound-54 DM2X4R0 MI TT2F4OL DM2X4R0 MN Tissue transglutaminase (TG2) DM2X4R0 MT DTT DM2X4R0 MA Inhibitor DM2X4R0 RN Transglutaminase inhibitors: a patent review.Expert Opin Ther Pat. 2016;26(1):49-63. DM2X4R0 RU https://www.ncbi.nlm.nih.gov/pubmed/26560530 DMMHL2C DI DMMHL2C DMMHL2C DN PMID26560530-Compound-6 DMMHL2C MI TT2F4OL DMMHL2C MN Tissue transglutaminase (TG2) DMMHL2C MT DTT DMMHL2C MA Inhibitor DMMHL2C RN Transglutaminase inhibitors: a patent review.Expert Opin Ther Pat. 2016;26(1):49-63. DMMHL2C RU https://www.ncbi.nlm.nih.gov/pubmed/26560530 DMRAXD1 DI DMRAXD1 DMRAXD1 DN PMID26560530-Compound-7 DMRAXD1 MI TT2F4OL DMRAXD1 MN Tissue transglutaminase (TG2) DMRAXD1 MT DTT DMRAXD1 MA Inhibitor DMRAXD1 RN Transglutaminase inhibitors: a patent review.Expert Opin Ther Pat. 2016;26(1):49-63. DMRAXD1 RU https://www.ncbi.nlm.nih.gov/pubmed/26560530 DMN6TG7 DI DMN6TG7 DMN6TG7 DN PMID26560530-Compound-8 DMN6TG7 MI TT2F4OL DMN6TG7 MN Tissue transglutaminase (TG2) DMN6TG7 MT DTT DMN6TG7 MA Inhibitor DMN6TG7 RN Transglutaminase inhibitors: a patent review.Expert Opin Ther Pat. 2016;26(1):49-63. DMN6TG7 RU https://www.ncbi.nlm.nih.gov/pubmed/26560530 DMBYTSI DI DMBYTSI DMBYTSI DN PMID26609882-Compound-34 DMBYTSI MI TTJQOD7 DMBYTSI MN 5-HT 2A receptor (HTR2A) DMBYTSI MT DTT DMBYTSI MA Antagonist DMBYTSI RN Novel serotonin receptor 2 (5-HT2R) agonists and antagonists: a patent review (2004-2014).Expert Opin Ther Pat. 2016;26(1):89-106. DMBYTSI RU https://www.ncbi.nlm.nih.gov/pubmed/26609882 DM8OLYQ DI DM8OLYQ DM8OLYQ DN PMID26609882-Compound-35 DM8OLYQ MI TTJQOD7 DM8OLYQ MN 5-HT 2A receptor (HTR2A) DM8OLYQ MT DTT DM8OLYQ MA Antagonist DM8OLYQ RN Novel serotonin receptor 2 (5-HT2R) agonists and antagonists: a patent review (2004-2014).Expert Opin Ther Pat. 2016;26(1):89-106. DM8OLYQ RU https://www.ncbi.nlm.nih.gov/pubmed/26609882 DMFT3RM DI DMFT3RM DMFT3RM DN PMID26609882-Compound-36 DMFT3RM MI TTJQOD7 DMFT3RM MN 5-HT 2A receptor (HTR2A) DMFT3RM MT DTT DMFT3RM MA Antagonist DMFT3RM RN Novel serotonin receptor 2 (5-HT2R) agonists and antagonists: a patent review (2004-2014).Expert Opin Ther Pat. 2016;26(1):89-106. DMFT3RM RU https://www.ncbi.nlm.nih.gov/pubmed/26609882 DMD3T1Q DI DMD3T1Q DMD3T1Q DN PMID26609882-Compound-58 DMD3T1Q MI TTWJBZ5 DMD3T1Q MN 5-HT 2C receptor (HTR2C) DMD3T1Q MT DTT DMD3T1Q MA Antagonist DMD3T1Q RN Novel serotonin receptor 2 (5-HT2R) agonists and antagonists: a patent review (2004-2014).Expert Opin Ther Pat. 2016;26(1):89-106. DMD3T1Q RU https://www.ncbi.nlm.nih.gov/pubmed/26609882 DM6C45G DI DM6C45G DM6C45G DN PMID26609882-Compound-83 DM6C45G MI TTWJBZ5 DM6C45G MN 5-HT 2C receptor (HTR2C) DM6C45G MT DTT DM6C45G MA Agonist DM6C45G RN Novel serotonin receptor 2 (5-HT2R) agonists and antagonists: a patent review (2004-2014).Expert Opin Ther Pat. 2016;26(1):89-106. DM6C45G RU https://www.ncbi.nlm.nih.gov/pubmed/26609882 DMOJVK6 DI DMOJVK6 DMOJVK6 DN PMID26651364-Compound-105 DMOJVK6 MI TTTCRU2 DMOJVK6 MN Bacterial Fimbrin D-mannose adhesin (Bact FimH) DMOJVK6 MT DTT DMOJVK6 MA Antagonist DMOJVK6 RN Mannose-derived FimH antagonists: a promising anti-virulence therapeutic strategy for urinary tract infections and Crohn's disease.Expert Opin Ther Pat. 2016;26(2):175-97. DMOJVK6 RU https://www.ncbi.nlm.nih.gov/pubmed/26651364 DMQZJDF DI DMQZJDF DMQZJDF DN PMID26651364-Compound-106 DMQZJDF MI TTTCRU2 DMQZJDF MN Bacterial Fimbrin D-mannose adhesin (Bact FimH) DMQZJDF MT DTT DMQZJDF MA Antagonist DMQZJDF RN Mannose-derived FimH antagonists: a promising anti-virulence therapeutic strategy for urinary tract infections and Crohn's disease.Expert Opin Ther Pat. 2016;26(2):175-97. DMQZJDF RU https://www.ncbi.nlm.nih.gov/pubmed/26651364 DMMZ1WL DI DMMZ1WL DMMZ1WL DN PMID26651364-Compound-107 DMMZ1WL MI TTTCRU2 DMMZ1WL MN Bacterial Fimbrin D-mannose adhesin (Bact FimH) DMMZ1WL MT DTT DMMZ1WL MA Antagonist DMMZ1WL RN Mannose-derived FimH antagonists: a promising anti-virulence therapeutic strategy for urinary tract infections and Crohn's disease.Expert Opin Ther Pat. 2016;26(2):175-97. DMMZ1WL RU https://www.ncbi.nlm.nih.gov/pubmed/26651364 DMA7D3K DI DMA7D3K DMA7D3K DN PMID26651364-Compound-108 DMA7D3K MI TTTCRU2 DMA7D3K MN Bacterial Fimbrin D-mannose adhesin (Bact FimH) DMA7D3K MT DTT DMA7D3K MA Antagonist DMA7D3K RN Mannose-derived FimH antagonists: a promising anti-virulence therapeutic strategy for urinary tract infections and Crohn's disease.Expert Opin Ther Pat. 2016;26(2):175-97. DMA7D3K RU https://www.ncbi.nlm.nih.gov/pubmed/26651364 DM01IWV DI DM01IWV DM01IWV DN PMID26651364-Compound-109 DM01IWV MI TTTCRU2 DM01IWV MN Bacterial Fimbrin D-mannose adhesin (Bact FimH) DM01IWV MT DTT DM01IWV MA Antagonist DM01IWV RN Mannose-derived FimH antagonists: a promising anti-virulence therapeutic strategy for urinary tract infections and Crohn's disease.Expert Opin Ther Pat. 2016;26(2):175-97. DM01IWV RU https://www.ncbi.nlm.nih.gov/pubmed/26651364 DMTPBNY DI DMTPBNY DMTPBNY DN PMID26651364-Compound-10a DMTPBNY MI TTTCRU2 DMTPBNY MN Bacterial Fimbrin D-mannose adhesin (Bact FimH) DMTPBNY MT DTT DMTPBNY MA Antagonist DMTPBNY RN Mannose-derived FimH antagonists: a promising anti-virulence therapeutic strategy for urinary tract infections and Crohn's disease.Expert Opin Ther Pat. 2016;26(2):175-97. DMTPBNY RU https://www.ncbi.nlm.nih.gov/pubmed/26651364 DM16ANH DI DM16ANH DM16ANH DN PMID26651364-Compound-10b DM16ANH MI TTTCRU2 DM16ANH MN Bacterial Fimbrin D-mannose adhesin (Bact FimH) DM16ANH MT DTT DM16ANH MA Antagonist DM16ANH RN Mannose-derived FimH antagonists: a promising anti-virulence therapeutic strategy for urinary tract infections and Crohn's disease.Expert Opin Ther Pat. 2016;26(2):175-97. DM16ANH RU https://www.ncbi.nlm.nih.gov/pubmed/26651364 DMCRNWA DI DMCRNWA DMCRNWA DN PMID26651364-Compound-10c DMCRNWA MI TTTCRU2 DMCRNWA MN Bacterial Fimbrin D-mannose adhesin (Bact FimH) DMCRNWA MT DTT DMCRNWA MA Antagonist DMCRNWA RN Mannose-derived FimH antagonists: a promising anti-virulence therapeutic strategy for urinary tract infections and Crohn's disease.Expert Opin Ther Pat. 2016;26(2):175-97. DMCRNWA RU https://www.ncbi.nlm.nih.gov/pubmed/26651364 DMGIV3C DI DMGIV3C DMGIV3C DN PMID26651364-Compound-10d DMGIV3C MI TTTCRU2 DMGIV3C MN Bacterial Fimbrin D-mannose adhesin (Bact FimH) DMGIV3C MT DTT DMGIV3C MA Antagonist DMGIV3C RN Mannose-derived FimH antagonists: a promising anti-virulence therapeutic strategy for urinary tract infections and Crohn's disease.Expert Opin Ther Pat. 2016;26(2):175-97. DMGIV3C RU https://www.ncbi.nlm.nih.gov/pubmed/26651364 DMPA3IX DI DMPA3IX DMPA3IX DN PMID26651364-Compound-110 DMPA3IX MI TTTCRU2 DMPA3IX MN Bacterial Fimbrin D-mannose adhesin (Bact FimH) DMPA3IX MT DTT DMPA3IX MA Antagonist DMPA3IX RN Mannose-derived FimH antagonists: a promising anti-virulence therapeutic strategy for urinary tract infections and Crohn's disease.Expert Opin Ther Pat. 2016;26(2):175-97. DMPA3IX RU https://www.ncbi.nlm.nih.gov/pubmed/26651364 DMY9R58 DI DMY9R58 DMY9R58 DN PMID26651364-Compound-111 DMY9R58 MI TTTCRU2 DMY9R58 MN Bacterial Fimbrin D-mannose adhesin (Bact FimH) DMY9R58 MT DTT DMY9R58 MA Antagonist DMY9R58 RN Mannose-derived FimH antagonists: a promising anti-virulence therapeutic strategy for urinary tract infections and Crohn's disease.Expert Opin Ther Pat. 2016;26(2):175-97. DMY9R58 RU https://www.ncbi.nlm.nih.gov/pubmed/26651364 DM1LIRP DI DM1LIRP DM1LIRP DN PMID26651364-Compound-112 DM1LIRP MI TTTCRU2 DM1LIRP MN Bacterial Fimbrin D-mannose adhesin (Bact FimH) DM1LIRP MT DTT DM1LIRP MA Antagonist DM1LIRP RN Mannose-derived FimH antagonists: a promising anti-virulence therapeutic strategy for urinary tract infections and Crohn's disease.Expert Opin Ther Pat. 2016;26(2):175-97. DM1LIRP RU https://www.ncbi.nlm.nih.gov/pubmed/26651364 DM6OQKM DI DM6OQKM DM6OQKM DN PMID26651364-Compound-113 DM6OQKM MI TTTCRU2 DM6OQKM MN Bacterial Fimbrin D-mannose adhesin (Bact FimH) DM6OQKM MT DTT DM6OQKM MA Antagonist DM6OQKM RN Mannose-derived FimH antagonists: a promising anti-virulence therapeutic strategy for urinary tract infections and Crohn's disease.Expert Opin Ther Pat. 2016;26(2):175-97. DM6OQKM RU https://www.ncbi.nlm.nih.gov/pubmed/26651364 DM5GHJA DI DM5GHJA DM5GHJA DN PMID26651364-Compound-114 DM5GHJA MI TTTCRU2 DM5GHJA MN Bacterial Fimbrin D-mannose adhesin (Bact FimH) DM5GHJA MT DTT DM5GHJA MA Antagonist DM5GHJA RN Mannose-derived FimH antagonists: a promising anti-virulence therapeutic strategy for urinary tract infections and Crohn's disease.Expert Opin Ther Pat. 2016;26(2):175-97. DM5GHJA RU https://www.ncbi.nlm.nih.gov/pubmed/26651364 DMHIA26 DI DMHIA26 DMHIA26 DN PMID26651364-Compound-115 DMHIA26 MI TTTCRU2 DMHIA26 MN Bacterial Fimbrin D-mannose adhesin (Bact FimH) DMHIA26 MT DTT DMHIA26 MA Antagonist DMHIA26 RN Mannose-derived FimH antagonists: a promising anti-virulence therapeutic strategy for urinary tract infections and Crohn's disease.Expert Opin Ther Pat. 2016;26(2):175-97. DMHIA26 RU https://www.ncbi.nlm.nih.gov/pubmed/26651364 DMJ3201 DI DMJ3201 DMJ3201 DN PMID26651364-Compound-116 DMJ3201 MI TTTCRU2 DMJ3201 MN Bacterial Fimbrin D-mannose adhesin (Bact FimH) DMJ3201 MT DTT DMJ3201 MA Antagonist DMJ3201 RN Mannose-derived FimH antagonists: a promising anti-virulence therapeutic strategy for urinary tract infections and Crohn's disease.Expert Opin Ther Pat. 2016;26(2):175-97. DMJ3201 RU https://www.ncbi.nlm.nih.gov/pubmed/26651364 DM6LXHS DI DM6LXHS DM6LXHS DN PMID26651364-Compound-117a DM6LXHS MI TTTCRU2 DM6LXHS MN Bacterial Fimbrin D-mannose adhesin (Bact FimH) DM6LXHS MT DTT DM6LXHS MA Antagonist DM6LXHS RN Mannose-derived FimH antagonists: a promising anti-virulence therapeutic strategy for urinary tract infections and Crohn's disease.Expert Opin Ther Pat. 2016;26(2):175-97. DM6LXHS RU https://www.ncbi.nlm.nih.gov/pubmed/26651364 DMUQSM1 DI DMUQSM1 DMUQSM1 DN PMID26651364-Compound-117b DMUQSM1 MI TTTCRU2 DMUQSM1 MN Bacterial Fimbrin D-mannose adhesin (Bact FimH) DMUQSM1 MT DTT DMUQSM1 MA Antagonist DMUQSM1 RN Mannose-derived FimH antagonists: a promising anti-virulence therapeutic strategy for urinary tract infections and Crohn's disease.Expert Opin Ther Pat. 2016;26(2):175-97. DMUQSM1 RU https://www.ncbi.nlm.nih.gov/pubmed/26651364 DM6ZRV4 DI DM6ZRV4 DM6ZRV4 DN PMID26651364-Compound-118 DM6ZRV4 MI TTTCRU2 DM6ZRV4 MN Bacterial Fimbrin D-mannose adhesin (Bact FimH) DM6ZRV4 MT DTT DM6ZRV4 MA Antagonist DM6ZRV4 RN Mannose-derived FimH antagonists: a promising anti-virulence therapeutic strategy for urinary tract infections and Crohn's disease.Expert Opin Ther Pat. 2016;26(2):175-97. DM6ZRV4 RU https://www.ncbi.nlm.nih.gov/pubmed/26651364 DMONAZI DI DMONAZI DMONAZI DN PMID26651364-Compound-119 DMONAZI MI TTTCRU2 DMONAZI MN Bacterial Fimbrin D-mannose adhesin (Bact FimH) DMONAZI MT DTT DMONAZI MA Antagonist DMONAZI RN Mannose-derived FimH antagonists: a promising anti-virulence therapeutic strategy for urinary tract infections and Crohn's disease.Expert Opin Ther Pat. 2016;26(2):175-97. DMONAZI RU https://www.ncbi.nlm.nih.gov/pubmed/26651364 DMGBFK3 DI DMGBFK3 DMGBFK3 DN PMID26651364-Compound-11b DMGBFK3 MI TTTCRU2 DMGBFK3 MN Bacterial Fimbrin D-mannose adhesin (Bact FimH) DMGBFK3 MT DTT DMGBFK3 MA Antagonist DMGBFK3 RN Mannose-derived FimH antagonists: a promising anti-virulence therapeutic strategy for urinary tract infections and Crohn's disease.Expert Opin Ther Pat. 2016;26(2):175-97. DMGBFK3 RU https://www.ncbi.nlm.nih.gov/pubmed/26651364 DM76WBP DI DM76WBP DM76WBP DN PMID26651364-Compound-11c DM76WBP MI TTTCRU2 DM76WBP MN Bacterial Fimbrin D-mannose adhesin (Bact FimH) DM76WBP MT DTT DM76WBP MA Antagonist DM76WBP RN Mannose-derived FimH antagonists: a promising anti-virulence therapeutic strategy for urinary tract infections and Crohn's disease.Expert Opin Ther Pat. 2016;26(2):175-97. DM76WBP RU https://www.ncbi.nlm.nih.gov/pubmed/26651364 DMZTBEQ DI DMZTBEQ DMZTBEQ DN PMID26651364-Compound-120 DMZTBEQ MI TTTCRU2 DMZTBEQ MN Bacterial Fimbrin D-mannose adhesin (Bact FimH) DMZTBEQ MT DTT DMZTBEQ MA Antagonist DMZTBEQ RN Mannose-derived FimH antagonists: a promising anti-virulence therapeutic strategy for urinary tract infections and Crohn's disease.Expert Opin Ther Pat. 2016;26(2):175-97. DMZTBEQ RU https://www.ncbi.nlm.nih.gov/pubmed/26651364 DM4ZG0Q DI DM4ZG0Q DM4ZG0Q DN PMID26651364-Compound-121 DM4ZG0Q MI TTTCRU2 DM4ZG0Q MN Bacterial Fimbrin D-mannose adhesin (Bact FimH) DM4ZG0Q MT DTT DM4ZG0Q MA Antagonist DM4ZG0Q RN Mannose-derived FimH antagonists: a promising anti-virulence therapeutic strategy for urinary tract infections and Crohn's disease.Expert Opin Ther Pat. 2016;26(2):175-97. DM4ZG0Q RU https://www.ncbi.nlm.nih.gov/pubmed/26651364 DMVFTIL DI DMVFTIL DMVFTIL DN PMID26651364-Compound-122 DMVFTIL MI TTTCRU2 DMVFTIL MN Bacterial Fimbrin D-mannose adhesin (Bact FimH) DMVFTIL MT DTT DMVFTIL MA Antagonist DMVFTIL RN Mannose-derived FimH antagonists: a promising anti-virulence therapeutic strategy for urinary tract infections and Crohn's disease.Expert Opin Ther Pat. 2016;26(2):175-97. DMVFTIL RU https://www.ncbi.nlm.nih.gov/pubmed/26651364 DMR0E5W DI DMR0E5W DMR0E5W DN PMID26651364-Compound-123 DMR0E5W MI TTTCRU2 DMR0E5W MN Bacterial Fimbrin D-mannose adhesin (Bact FimH) DMR0E5W MT DTT DMR0E5W MA Antagonist DMR0E5W RN Mannose-derived FimH antagonists: a promising anti-virulence therapeutic strategy for urinary tract infections and Crohn's disease.Expert Opin Ther Pat. 2016;26(2):175-97. DMR0E5W RU https://www.ncbi.nlm.nih.gov/pubmed/26651364 DM6VER5 DI DM6VER5 DM6VER5 DN PMID26651364-Compound-124 DM6VER5 MI TTTCRU2 DM6VER5 MN Bacterial Fimbrin D-mannose adhesin (Bact FimH) DM6VER5 MT DTT DM6VER5 MA Antagonist DM6VER5 RN Mannose-derived FimH antagonists: a promising anti-virulence therapeutic strategy for urinary tract infections and Crohn's disease.Expert Opin Ther Pat. 2016;26(2):175-97. DM6VER5 RU https://www.ncbi.nlm.nih.gov/pubmed/26651364 DMINUDB DI DMINUDB DMINUDB DN PMID26651364-Compound-125 DMINUDB MI TTTCRU2 DMINUDB MN Bacterial Fimbrin D-mannose adhesin (Bact FimH) DMINUDB MT DTT DMINUDB MA Antagonist DMINUDB RN Mannose-derived FimH antagonists: a promising anti-virulence therapeutic strategy for urinary tract infections and Crohn's disease.Expert Opin Ther Pat. 2016;26(2):175-97. DMINUDB RU https://www.ncbi.nlm.nih.gov/pubmed/26651364 DMSTKH6 DI DMSTKH6 DMSTKH6 DN PMID26651364-Compound-126a DMSTKH6 MI TTTCRU2 DMSTKH6 MN Bacterial Fimbrin D-mannose adhesin (Bact FimH) DMSTKH6 MT DTT DMSTKH6 MA Antagonist DMSTKH6 RN Mannose-derived FimH antagonists: a promising anti-virulence therapeutic strategy for urinary tract infections and Crohn's disease.Expert Opin Ther Pat. 2016;26(2):175-97. DMSTKH6 RU https://www.ncbi.nlm.nih.gov/pubmed/26651364 DM2I1QZ DI DM2I1QZ DM2I1QZ DN PMID26651364-Compound-126b DM2I1QZ MI TTTCRU2 DM2I1QZ MN Bacterial Fimbrin D-mannose adhesin (Bact FimH) DM2I1QZ MT DTT DM2I1QZ MA Antagonist DM2I1QZ RN Mannose-derived FimH antagonists: a promising anti-virulence therapeutic strategy for urinary tract infections and Crohn's disease.Expert Opin Ther Pat. 2016;26(2):175-97. DM2I1QZ RU https://www.ncbi.nlm.nih.gov/pubmed/26651364 DM80PI1 DI DM80PI1 DM80PI1 DN PMID26651364-Compound-126c DM80PI1 MI TTTCRU2 DM80PI1 MN Bacterial Fimbrin D-mannose adhesin (Bact FimH) DM80PI1 MT DTT DM80PI1 MA Antagonist DM80PI1 RN Mannose-derived FimH antagonists: a promising anti-virulence therapeutic strategy for urinary tract infections and Crohn's disease.Expert Opin Ther Pat. 2016;26(2):175-97. DM80PI1 RU https://www.ncbi.nlm.nih.gov/pubmed/26651364 DMEN8RA DI DMEN8RA DMEN8RA DN PMID26651364-Compound-127 DMEN8RA MI TTTCRU2 DMEN8RA MN Bacterial Fimbrin D-mannose adhesin (Bact FimH) DMEN8RA MT DTT DMEN8RA MA Antagonist DMEN8RA RN Mannose-derived FimH antagonists: a promising anti-virulence therapeutic strategy for urinary tract infections and Crohn's disease.Expert Opin Ther Pat. 2016;26(2):175-97. DMEN8RA RU https://www.ncbi.nlm.nih.gov/pubmed/26651364 DM4W0BX DI DM4W0BX DM4W0BX DN PMID26651364-Compound-128 DM4W0BX MI TTTCRU2 DM4W0BX MN Bacterial Fimbrin D-mannose adhesin (Bact FimH) DM4W0BX MT DTT DM4W0BX MA Antagonist DM4W0BX RN Mannose-derived FimH antagonists: a promising anti-virulence therapeutic strategy for urinary tract infections and Crohn's disease.Expert Opin Ther Pat. 2016;26(2):175-97. DM4W0BX RU https://www.ncbi.nlm.nih.gov/pubmed/26651364 DMY0HP1 DI DMY0HP1 DMY0HP1 DN PMID26651364-Compound-4 DMY0HP1 MI TTTCRU2 DMY0HP1 MN Bacterial Fimbrin D-mannose adhesin (Bact FimH) DMY0HP1 MT DTT DMY0HP1 MA Antagonist DMY0HP1 RN Mannose-derived FimH antagonists: a promising anti-virulence therapeutic strategy for urinary tract infections and Crohn's disease.Expert Opin Ther Pat. 2016;26(2):175-97. DMY0HP1 RU https://www.ncbi.nlm.nih.gov/pubmed/26651364 DMLBZGO DI DMLBZGO DMLBZGO DN PMID26651364-Compound-45 DMLBZGO MI TTTCRU2 DMLBZGO MN Bacterial Fimbrin D-mannose adhesin (Bact FimH) DMLBZGO MT DTT DMLBZGO MA Antagonist DMLBZGO RN Mannose-derived FimH antagonists: a promising anti-virulence therapeutic strategy for urinary tract infections and Crohn's disease.Expert Opin Ther Pat. 2016;26(2):175-97. DMLBZGO RU https://www.ncbi.nlm.nih.gov/pubmed/26651364 DMQFDU8 DI DMQFDU8 DMQFDU8 DN PMID26651364-Compound-46 DMQFDU8 MI TTTCRU2 DMQFDU8 MN Bacterial Fimbrin D-mannose adhesin (Bact FimH) DMQFDU8 MT DTT DMQFDU8 MA Antagonist DMQFDU8 RN Mannose-derived FimH antagonists: a promising anti-virulence therapeutic strategy for urinary tract infections and Crohn's disease.Expert Opin Ther Pat. 2016;26(2):175-97. DMQFDU8 RU https://www.ncbi.nlm.nih.gov/pubmed/26651364 DM4S5PB DI DM4S5PB DM4S5PB DN PMID26651364-Compound-47 DM4S5PB MI TTTCRU2 DM4S5PB MN Bacterial Fimbrin D-mannose adhesin (Bact FimH) DM4S5PB MT DTT DM4S5PB MA Antagonist DM4S5PB RN Mannose-derived FimH antagonists: a promising anti-virulence therapeutic strategy for urinary tract infections and Crohn's disease.Expert Opin Ther Pat. 2016;26(2):175-97. DM4S5PB RU https://www.ncbi.nlm.nih.gov/pubmed/26651364 DMHXFGU DI DMHXFGU DMHXFGU DN PMID26651364-Compound-48 DMHXFGU MI TTTCRU2 DMHXFGU MN Bacterial Fimbrin D-mannose adhesin (Bact FimH) DMHXFGU MT DTT DMHXFGU MA Antagonist DMHXFGU RN Mannose-derived FimH antagonists: a promising anti-virulence therapeutic strategy for urinary tract infections and Crohn's disease.Expert Opin Ther Pat. 2016;26(2):175-97. DMHXFGU RU https://www.ncbi.nlm.nih.gov/pubmed/26651364 DMMV5A9 DI DMMV5A9 DMMV5A9 DN PMID26651364-Compound-49 DMMV5A9 MI TTTCRU2 DMMV5A9 MN Bacterial Fimbrin D-mannose adhesin (Bact FimH) DMMV5A9 MT DTT DMMV5A9 MA Antagonist DMMV5A9 RN Mannose-derived FimH antagonists: a promising anti-virulence therapeutic strategy for urinary tract infections and Crohn's disease.Expert Opin Ther Pat. 2016;26(2):175-97. DMMV5A9 RU https://www.ncbi.nlm.nih.gov/pubmed/26651364 DMH7XL3 DI DMH7XL3 DMH7XL3 DN PMID26651364-Compound-5 DMH7XL3 MI TTTCRU2 DMH7XL3 MN Bacterial Fimbrin D-mannose adhesin (Bact FimH) DMH7XL3 MT DTT DMH7XL3 MA Antagonist DMH7XL3 RN Mannose-derived FimH antagonists: a promising anti-virulence therapeutic strategy for urinary tract infections and Crohn's disease.Expert Opin Ther Pat. 2016;26(2):175-97. DMH7XL3 RU https://www.ncbi.nlm.nih.gov/pubmed/26651364 DM6GFYR DI DM6GFYR DM6GFYR DN PMID26651364-Compound-50 DM6GFYR MI TTTCRU2 DM6GFYR MN Bacterial Fimbrin D-mannose adhesin (Bact FimH) DM6GFYR MT DTT DM6GFYR MA Antagonist DM6GFYR RN Mannose-derived FimH antagonists: a promising anti-virulence therapeutic strategy for urinary tract infections and Crohn's disease.Expert Opin Ther Pat. 2016;26(2):175-97. DM6GFYR RU https://www.ncbi.nlm.nih.gov/pubmed/26651364 DM01GVE DI DM01GVE DM01GVE DN PMID26651364-Compound-5a DM01GVE MI TTTCRU2 DM01GVE MN Bacterial Fimbrin D-mannose adhesin (Bact FimH) DM01GVE MT DTT DM01GVE MA Antagonist DM01GVE RN Mannose-derived FimH antagonists: a promising anti-virulence therapeutic strategy for urinary tract infections and Crohn's disease.Expert Opin Ther Pat. 2016;26(2):175-97. DM01GVE RU https://www.ncbi.nlm.nih.gov/pubmed/26651364 DMLHJ1E DI DMLHJ1E DMLHJ1E DN PMID26651364-Compound-5b DMLHJ1E MI TTTCRU2 DMLHJ1E MN Bacterial Fimbrin D-mannose adhesin (Bact FimH) DMLHJ1E MT DTT DMLHJ1E MA Antagonist DMLHJ1E RN Mannose-derived FimH antagonists: a promising anti-virulence therapeutic strategy for urinary tract infections and Crohn's disease.Expert Opin Ther Pat. 2016;26(2):175-97. DMLHJ1E RU https://www.ncbi.nlm.nih.gov/pubmed/26651364 DMDQTA2 DI DMDQTA2 DMDQTA2 DN PMID26651364-Compound-5c DMDQTA2 MI TTTCRU2 DMDQTA2 MN Bacterial Fimbrin D-mannose adhesin (Bact FimH) DMDQTA2 MT DTT DMDQTA2 MA Antagonist DMDQTA2 RN Mannose-derived FimH antagonists: a promising anti-virulence therapeutic strategy for urinary tract infections and Crohn's disease.Expert Opin Ther Pat. 2016;26(2):175-97. DMDQTA2 RU https://www.ncbi.nlm.nih.gov/pubmed/26651364 DMF6Z5I DI DMF6Z5I DMF6Z5I DN PMID26651364-Compound-5d DMF6Z5I MI TTTCRU2 DMF6Z5I MN Bacterial Fimbrin D-mannose adhesin (Bact FimH) DMF6Z5I MT DTT DMF6Z5I MA Antagonist DMF6Z5I RN Mannose-derived FimH antagonists: a promising anti-virulence therapeutic strategy for urinary tract infections and Crohn's disease.Expert Opin Ther Pat. 2016;26(2):175-97. DMF6Z5I RU https://www.ncbi.nlm.nih.gov/pubmed/26651364 DM9TJR5 DI DM9TJR5 DM9TJR5 DN PMID26651364-Compound-5e DM9TJR5 MI TTTCRU2 DM9TJR5 MN Bacterial Fimbrin D-mannose adhesin (Bact FimH) DM9TJR5 MT DTT DM9TJR5 MA Antagonist DM9TJR5 RN Mannose-derived FimH antagonists: a promising anti-virulence therapeutic strategy for urinary tract infections and Crohn's disease.Expert Opin Ther Pat. 2016;26(2):175-97. DM9TJR5 RU https://www.ncbi.nlm.nih.gov/pubmed/26651364 DMAZIY6 DI DMAZIY6 DMAZIY6 DN PMID26651364-Compound-5f DMAZIY6 MI TTTCRU2 DMAZIY6 MN Bacterial Fimbrin D-mannose adhesin (Bact FimH) DMAZIY6 MT DTT DMAZIY6 MA Antagonist DMAZIY6 RN Mannose-derived FimH antagonists: a promising anti-virulence therapeutic strategy for urinary tract infections and Crohn's disease.Expert Opin Ther Pat. 2016;26(2):175-97. DMAZIY6 RU https://www.ncbi.nlm.nih.gov/pubmed/26651364 DMSW0HB DI DMSW0HB DMSW0HB DN PMID26651364-Compound-5g DMSW0HB MI TTTCRU2 DMSW0HB MN Bacterial Fimbrin D-mannose adhesin (Bact FimH) DMSW0HB MT DTT DMSW0HB MA Antagonist DMSW0HB RN Mannose-derived FimH antagonists: a promising anti-virulence therapeutic strategy for urinary tract infections and Crohn's disease.Expert Opin Ther Pat. 2016;26(2):175-97. DMSW0HB RU https://www.ncbi.nlm.nih.gov/pubmed/26651364 DM8HAJ3 DI DM8HAJ3 DM8HAJ3 DN PMID26651364-Compound-6a DM8HAJ3 MI TTTCRU2 DM8HAJ3 MN Bacterial Fimbrin D-mannose adhesin (Bact FimH) DM8HAJ3 MT DTT DM8HAJ3 MA Antagonist DM8HAJ3 RN Mannose-derived FimH antagonists: a promising anti-virulence therapeutic strategy for urinary tract infections and Crohn's disease.Expert Opin Ther Pat. 2016;26(2):175-97. DM8HAJ3 RU https://www.ncbi.nlm.nih.gov/pubmed/26651364 DMBINOJ DI DMBINOJ DMBINOJ DN PMID26651364-Compound-6b DMBINOJ MI TTTCRU2 DMBINOJ MN Bacterial Fimbrin D-mannose adhesin (Bact FimH) DMBINOJ MT DTT DMBINOJ MA Antagonist DMBINOJ RN Mannose-derived FimH antagonists: a promising anti-virulence therapeutic strategy for urinary tract infections and Crohn's disease.Expert Opin Ther Pat. 2016;26(2):175-97. DMBINOJ RU https://www.ncbi.nlm.nih.gov/pubmed/26651364 DMPF86L DI DMPF86L DMPF86L DN PMID26651364-Compound-6c DMPF86L MI TTTCRU2 DMPF86L MN Bacterial Fimbrin D-mannose adhesin (Bact FimH) DMPF86L MT DTT DMPF86L MA Antagonist DMPF86L RN Mannose-derived FimH antagonists: a promising anti-virulence therapeutic strategy for urinary tract infections and Crohn's disease.Expert Opin Ther Pat. 2016;26(2):175-97. DMPF86L RU https://www.ncbi.nlm.nih.gov/pubmed/26651364 DM9J57W DI DM9J57W DM9J57W DN PMID26651364-Compound-6d DM9J57W MI TTTCRU2 DM9J57W MN Bacterial Fimbrin D-mannose adhesin (Bact FimH) DM9J57W MT DTT DM9J57W MA Antagonist DM9J57W RN Mannose-derived FimH antagonists: a promising anti-virulence therapeutic strategy for urinary tract infections and Crohn's disease.Expert Opin Ther Pat. 2016;26(2):175-97. DM9J57W RU https://www.ncbi.nlm.nih.gov/pubmed/26651364 DM4LF0X DI DM4LF0X DM4LF0X DN PMID26651364-Compound-6e DM4LF0X MI TTTCRU2 DM4LF0X MN Bacterial Fimbrin D-mannose adhesin (Bact FimH) DM4LF0X MT DTT DM4LF0X MA Antagonist DM4LF0X RN Mannose-derived FimH antagonists: a promising anti-virulence therapeutic strategy for urinary tract infections and Crohn's disease.Expert Opin Ther Pat. 2016;26(2):175-97. DM4LF0X RU https://www.ncbi.nlm.nih.gov/pubmed/26651364 DMQMBY9 DI DMQMBY9 DMQMBY9 DN PMID26651364-Compound-7a DMQMBY9 MI TTTCRU2 DMQMBY9 MN Bacterial Fimbrin D-mannose adhesin (Bact FimH) DMQMBY9 MT DTT DMQMBY9 MA Antagonist DMQMBY9 RN Mannose-derived FimH antagonists: a promising anti-virulence therapeutic strategy for urinary tract infections and Crohn's disease.Expert Opin Ther Pat. 2016;26(2):175-97. DMQMBY9 RU https://www.ncbi.nlm.nih.gov/pubmed/26651364 DM3LCIM DI DM3LCIM DM3LCIM DN PMID26651364-Compound-7b DM3LCIM MI TTTCRU2 DM3LCIM MN Bacterial Fimbrin D-mannose adhesin (Bact FimH) DM3LCIM MT DTT DM3LCIM MA Antagonist DM3LCIM RN Mannose-derived FimH antagonists: a promising anti-virulence therapeutic strategy for urinary tract infections and Crohn's disease.Expert Opin Ther Pat. 2016;26(2):175-97. DM3LCIM RU https://www.ncbi.nlm.nih.gov/pubmed/26651364 DMGCUJB DI DMGCUJB DMGCUJB DN PMID26651364-Compound-7c DMGCUJB MI TTTCRU2 DMGCUJB MN Bacterial Fimbrin D-mannose adhesin (Bact FimH) DMGCUJB MT DTT DMGCUJB MA Antagonist DMGCUJB RN Mannose-derived FimH antagonists: a promising anti-virulence therapeutic strategy for urinary tract infections and Crohn's disease.Expert Opin Ther Pat. 2016;26(2):175-97. DMGCUJB RU https://www.ncbi.nlm.nih.gov/pubmed/26651364 DM89VQT DI DM89VQT DM89VQT DN PMID26651364-Compound-7d DM89VQT MI TTTCRU2 DM89VQT MN Bacterial Fimbrin D-mannose adhesin (Bact FimH) DM89VQT MT DTT DM89VQT MA Antagonist DM89VQT RN Mannose-derived FimH antagonists: a promising anti-virulence therapeutic strategy for urinary tract infections and Crohn's disease.Expert Opin Ther Pat. 2016;26(2):175-97. DM89VQT RU https://www.ncbi.nlm.nih.gov/pubmed/26651364 DM2SZ0B DI DM2SZ0B DM2SZ0B DN PMID26651364-Compound-7e DM2SZ0B MI TTTCRU2 DM2SZ0B MN Bacterial Fimbrin D-mannose adhesin (Bact FimH) DM2SZ0B MT DTT DM2SZ0B MA Antagonist DM2SZ0B RN Mannose-derived FimH antagonists: a promising anti-virulence therapeutic strategy for urinary tract infections and Crohn's disease.Expert Opin Ther Pat. 2016;26(2):175-97. DM2SZ0B RU https://www.ncbi.nlm.nih.gov/pubmed/26651364 DM1M3WF DI DM1M3WF DM1M3WF DN PMID26651364-Compound-8a DM1M3WF MI TTTCRU2 DM1M3WF MN Bacterial Fimbrin D-mannose adhesin (Bact FimH) DM1M3WF MT DTT DM1M3WF MA Antagonist DM1M3WF RN Mannose-derived FimH antagonists: a promising anti-virulence therapeutic strategy for urinary tract infections and Crohn's disease.Expert Opin Ther Pat. 2016;26(2):175-97. DM1M3WF RU https://www.ncbi.nlm.nih.gov/pubmed/26651364 DMYVU36 DI DMYVU36 DMYVU36 DN PMID26651364-Compound-8b DMYVU36 MI TTTCRU2 DMYVU36 MN Bacterial Fimbrin D-mannose adhesin (Bact FimH) DMYVU36 MT DTT DMYVU36 MA Antagonist DMYVU36 RN Mannose-derived FimH antagonists: a promising anti-virulence therapeutic strategy for urinary tract infections and Crohn's disease.Expert Opin Ther Pat. 2016;26(2):175-97. DMYVU36 RU https://www.ncbi.nlm.nih.gov/pubmed/26651364 DME7UNT DI DME7UNT DME7UNT DN PMID26651364-Compound-8c DME7UNT MI TTTCRU2 DME7UNT MN Bacterial Fimbrin D-mannose adhesin (Bact FimH) DME7UNT MT DTT DME7UNT MA Antagonist DME7UNT RN Mannose-derived FimH antagonists: a promising anti-virulence therapeutic strategy for urinary tract infections and Crohn's disease.Expert Opin Ther Pat. 2016;26(2):175-97. DME7UNT RU https://www.ncbi.nlm.nih.gov/pubmed/26651364 DMSO2F8 DI DMSO2F8 DMSO2F8 DN PMID26651364-Compound-8d DMSO2F8 MI TTTCRU2 DMSO2F8 MN Bacterial Fimbrin D-mannose adhesin (Bact FimH) DMSO2F8 MT DTT DMSO2F8 MA Antagonist DMSO2F8 RN Mannose-derived FimH antagonists: a promising anti-virulence therapeutic strategy for urinary tract infections and Crohn's disease.Expert Opin Ther Pat. 2016;26(2):175-97. DMSO2F8 RU https://www.ncbi.nlm.nih.gov/pubmed/26651364 DMAXWPS DI DMAXWPS DMAXWPS DN PMID26651364-Compound-9a DMAXWPS MI TTTCRU2 DMAXWPS MN Bacterial Fimbrin D-mannose adhesin (Bact FimH) DMAXWPS MT DTT DMAXWPS MA Antagonist DMAXWPS RN Mannose-derived FimH antagonists: a promising anti-virulence therapeutic strategy for urinary tract infections and Crohn's disease.Expert Opin Ther Pat. 2016;26(2):175-97. DMAXWPS RU https://www.ncbi.nlm.nih.gov/pubmed/26651364 DM6HTU0 DI DM6HTU0 DM6HTU0 DN PMID26651364-Compound-9b DM6HTU0 MI TTTCRU2 DM6HTU0 MN Bacterial Fimbrin D-mannose adhesin (Bact FimH) DM6HTU0 MT DTT DM6HTU0 MA Antagonist DM6HTU0 RN Mannose-derived FimH antagonists: a promising anti-virulence therapeutic strategy for urinary tract infections and Crohn's disease.Expert Opin Ther Pat. 2016;26(2):175-97. DM6HTU0 RU https://www.ncbi.nlm.nih.gov/pubmed/26651364 DM49V8G DI DM49V8G DM49V8G DN PMID26651364-Compound-9c DM49V8G MI TTTCRU2 DM49V8G MN Bacterial Fimbrin D-mannose adhesin (Bact FimH) DM49V8G MT DTT DM49V8G MA Antagonist DM49V8G RN Mannose-derived FimH antagonists: a promising anti-virulence therapeutic strategy for urinary tract infections and Crohn's disease.Expert Opin Ther Pat. 2016;26(2):175-97. DM49V8G RU https://www.ncbi.nlm.nih.gov/pubmed/26651364 DMF0L3E DI DMF0L3E DMF0L3E DN PMID26651364-Compound-9d DMF0L3E MI TTTCRU2 DMF0L3E MN Bacterial Fimbrin D-mannose adhesin (Bact FimH) DMF0L3E MT DTT DMF0L3E MA Antagonist DMF0L3E RN Mannose-derived FimH antagonists: a promising anti-virulence therapeutic strategy for urinary tract infections and Crohn's disease.Expert Opin Ther Pat. 2016;26(2):175-97. DMF0L3E RU https://www.ncbi.nlm.nih.gov/pubmed/26651364 DM9FIKD DI DM9FIKD DM9FIKD DN PMID26651364-Compound-9e DM9FIKD MI TTTCRU2 DM9FIKD MN Bacterial Fimbrin D-mannose adhesin (Bact FimH) DM9FIKD MT DTT DM9FIKD MA Antagonist DM9FIKD RN Mannose-derived FimH antagonists: a promising anti-virulence therapeutic strategy for urinary tract infections and Crohn's disease.Expert Opin Ther Pat. 2016;26(2):175-97. DM9FIKD RU https://www.ncbi.nlm.nih.gov/pubmed/26651364 DMF1MV6 DI DMF1MV6 DMF1MV6 DN PMID26651364-Compound-9f DMF1MV6 MI TTTCRU2 DMF1MV6 MN Bacterial Fimbrin D-mannose adhesin (Bact FimH) DMF1MV6 MT DTT DMF1MV6 MA Antagonist DMF1MV6 RN Mannose-derived FimH antagonists: a promising anti-virulence therapeutic strategy for urinary tract infections and Crohn's disease.Expert Opin Ther Pat. 2016;26(2):175-97. DMF1MV6 RU https://www.ncbi.nlm.nih.gov/pubmed/26651364 DMMGQ7Z DI DMMGQ7Z DMMGQ7Z DN PMID26666870-Compound-16 DMMGQ7Z MI TTJOMH6 DMMGQ7Z MN Zinc finger protein GLI1 (Gli1) DMMGQ7Z MT DTT DMMGQ7Z MA Inhibitor DMMGQ7Z RN Evaluation of WO2014207069 A1: Multitarget Hedgehog pathway inhibitors and uses thereof.Expert Opin Ther Pat. 2016;26(4):529-35. DMMGQ7Z RU https://www.ncbi.nlm.nih.gov/pubmed/26666870 DMWJXRO DI DMWJXRO DMWJXRO DN PMID26666989-Compound-Figure11Ala down DMWJXRO MI TT8BUGW DMWJXRO MN Glycogen phosphorylase (PYG) DMWJXRO MT DTT DMWJXRO MA Inhibitor DMWJXRO RN Glycogen phosphorylase inhibitors: a patent review (2013 - 2015).Expert Opin Ther Pat. 2016;26(2):199-212. DMWJXRO RU https://www.ncbi.nlm.nih.gov/pubmed/26666989 DMGU914 DI DMGU914 DMGU914 DN PMID26666989-Compound-Figure11Ala up DMGU914 MI TT8BUGW DMGU914 MN Glycogen phosphorylase (PYG) DMGU914 MT DTT DMGU914 MA Inhibitor DMGU914 RN Glycogen phosphorylase inhibitors: a patent review (2013 - 2015).Expert Opin Ther Pat. 2016;26(2):199-212. DMGU914 RU https://www.ncbi.nlm.nih.gov/pubmed/26666989 DMA59QF DI DMA59QF DMA59QF DN PMID26666989-Compound-Figure11topright DMA59QF MI TT8BUGW DMA59QF MN Glycogen phosphorylase (PYG) DMA59QF MT DTT DMA59QF MA Inhibitor DMA59QF RN Glycogen phosphorylase inhibitors: a patent review (2013 - 2015).Expert Opin Ther Pat. 2016;26(2):199-212. DMA59QF RU https://www.ncbi.nlm.nih.gov/pubmed/26666989 DMGIPDH DI DMGIPDH DMGIPDH DN PMID26666989-Compound-Figure12bottommiddle01 DMGIPDH MI TT8BUGW DMGIPDH MN Glycogen phosphorylase (PYG) DMGIPDH MT DTT DMGIPDH MA Inhibitor DMGIPDH RN Glycogen phosphorylase inhibitors: a patent review (2013 - 2015).Expert Opin Ther Pat. 2016;26(2):199-212. DMGIPDH RU https://www.ncbi.nlm.nih.gov/pubmed/26666989 DM2VHJ7 DI DM2VHJ7 DM2VHJ7 DN PMID26666989-Compound-Figure12bottommiddle02 DM2VHJ7 MI TT8BUGW DM2VHJ7 MN Glycogen phosphorylase (PYG) DM2VHJ7 MT DTT DM2VHJ7 MA Inhibitor DM2VHJ7 RN Glycogen phosphorylase inhibitors: a patent review (2013 - 2015).Expert Opin Ther Pat. 2016;26(2):199-212. DM2VHJ7 RU https://www.ncbi.nlm.nih.gov/pubmed/26666989 DMDLVXU DI DMDLVXU DMDLVXU DN PMID26666989-Compound-Figure12bottomright DMDLVXU MI TT8BUGW DMDLVXU MN Glycogen phosphorylase (PYG) DMDLVXU MT DTT DMDLVXU MA Inhibitor DMDLVXU RN Glycogen phosphorylase inhibitors: a patent review (2013 - 2015).Expert Opin Ther Pat. 2016;26(2):199-212. DMDLVXU RU https://www.ncbi.nlm.nih.gov/pubmed/26666989 DMF5LNK DI DMF5LNK DMF5LNK DN PMID26666989-Compound-Figure12left DMF5LNK MI TT8BUGW DMF5LNK MN Glycogen phosphorylase (PYG) DMF5LNK MT DTT DMF5LNK MA Inhibitor DMF5LNK RN Glycogen phosphorylase inhibitors: a patent review (2013 - 2015).Expert Opin Ther Pat. 2016;26(2):199-212. DMF5LNK RU https://www.ncbi.nlm.nih.gov/pubmed/26666989 DMEUSGR DI DMEUSGR DMEUSGR DN PMID26666989-Compound-Figure12topmiddile DMEUSGR MI TT8BUGW DMEUSGR MN Glycogen phosphorylase (PYG) DMEUSGR MT DTT DMEUSGR MA Inhibitor DMEUSGR RN Glycogen phosphorylase inhibitors: a patent review (2013 - 2015).Expert Opin Ther Pat. 2016;26(2):199-212. DMEUSGR RU https://www.ncbi.nlm.nih.gov/pubmed/26666989 DMISJDH DI DMISJDH DMISJDH DN PMID26666989-Compound-Figure9bottomright DMISJDH MI TT8BUGW DMISJDH MN Glycogen phosphorylase (PYG) DMISJDH MT DTT DMISJDH MA Inhibitor DMISJDH RN Glycogen phosphorylase inhibitors: a patent review (2013 - 2015).Expert Opin Ther Pat. 2016;26(2):199-212. DMISJDH RU https://www.ncbi.nlm.nih.gov/pubmed/26666989 DM0NM1Y DI DM0NM1Y DM0NM1Y DN PMID26666989-Compound-Figure9left01 DM0NM1Y MI TT8BUGW DM0NM1Y MN Glycogen phosphorylase (PYG) DM0NM1Y MT DTT DM0NM1Y MA Inhibitor DM0NM1Y RN Glycogen phosphorylase inhibitors: a patent review (2013 - 2015).Expert Opin Ther Pat. 2016;26(2):199-212. DM0NM1Y RU https://www.ncbi.nlm.nih.gov/pubmed/26666989 DM7L6WS DI DM7L6WS DM7L6WS DN PMID26666989-Compound-Figure9left02 DM7L6WS MI TT8BUGW DM7L6WS MN Glycogen phosphorylase (PYG) DM7L6WS MT DTT DM7L6WS MA Inhibitor DM7L6WS RN Glycogen phosphorylase inhibitors: a patent review (2013 - 2015).Expert Opin Ther Pat. 2016;26(2):199-212. DM7L6WS RU https://www.ncbi.nlm.nih.gov/pubmed/26666989 DM4MA2X DI DM4MA2X DM4MA2X DN PMID26666989-Compound-Figure9middle01 DM4MA2X MI TT8BUGW DM4MA2X MN Glycogen phosphorylase (PYG) DM4MA2X MT DTT DM4MA2X MA Inhibitor DM4MA2X RN Glycogen phosphorylase inhibitors: a patent review (2013 - 2015).Expert Opin Ther Pat. 2016;26(2):199-212. DM4MA2X RU https://www.ncbi.nlm.nih.gov/pubmed/26666989 DM2ANJ7 DI DM2ANJ7 DM2ANJ7 DN PMID26666989-Compound-Figure9middle02 DM2ANJ7 MI TT8BUGW DM2ANJ7 MN Glycogen phosphorylase (PYG) DM2ANJ7 MT DTT DM2ANJ7 MA Inhibitor DM2ANJ7 RN Glycogen phosphorylase inhibitors: a patent review (2013 - 2015).Expert Opin Ther Pat. 2016;26(2):199-212. DM2ANJ7 RU https://www.ncbi.nlm.nih.gov/pubmed/26666989 DMOPR7A DI DMOPR7A DMOPR7A DN PMID26666989-Compound-Figure9middle03 DMOPR7A MI TT8BUGW DMOPR7A MN Glycogen phosphorylase (PYG) DMOPR7A MT DTT DMOPR7A MA Inhibitor DMOPR7A RN Glycogen phosphorylase inhibitors: a patent review (2013 - 2015).Expert Opin Ther Pat. 2016;26(2):199-212. DMOPR7A RU https://www.ncbi.nlm.nih.gov/pubmed/26666989 DMNWRA0 DI DMNWRA0 DMNWRA0 DN PMID26666989-Compound-Figure9middle04 DMNWRA0 MI TT8BUGW DMNWRA0 MN Glycogen phosphorylase (PYG) DMNWRA0 MT DTT DMNWRA0 MA Inhibitor DMNWRA0 RN Glycogen phosphorylase inhibitors: a patent review (2013 - 2015).Expert Opin Ther Pat. 2016;26(2):199-212. DMNWRA0 RU https://www.ncbi.nlm.nih.gov/pubmed/26666989 DMN73KO DI DMN73KO DMN73KO DN PMID26666989-Compound-Figure9middle05 DMN73KO MI TT8BUGW DMN73KO MN Glycogen phosphorylase (PYG) DMN73KO MT DTT DMN73KO MA Inhibitor DMN73KO RN Glycogen phosphorylase inhibitors: a patent review (2013 - 2015).Expert Opin Ther Pat. 2016;26(2):199-212. DMN73KO RU https://www.ncbi.nlm.nih.gov/pubmed/26666989 DMYKPHX DI DMYKPHX DMYKPHX DN PMID26666989-Compound-Figure9middle06 DMYKPHX MI TT8BUGW DMYKPHX MN Glycogen phosphorylase (PYG) DMYKPHX MT DTT DMYKPHX MA Inhibitor DMYKPHX RN Glycogen phosphorylase inhibitors: a patent review (2013 - 2015).Expert Opin Ther Pat. 2016;26(2):199-212. DMYKPHX RU https://www.ncbi.nlm.nih.gov/pubmed/26666989 DMA02ED DI DMA02ED DMA02ED DN PMID26666989-Compound-Figure9middle07 DMA02ED MI TT8BUGW DMA02ED MN Glycogen phosphorylase (PYG) DMA02ED MT DTT DMA02ED MA Inhibitor DMA02ED RN Glycogen phosphorylase inhibitors: a patent review (2013 - 2015).Expert Opin Ther Pat. 2016;26(2):199-212. DMA02ED RU https://www.ncbi.nlm.nih.gov/pubmed/26666989 DM8KF15 DI DM8KF15 DM8KF15 DN PMID26666989-Compound-Figure9middle08 DM8KF15 MI TT8BUGW DM8KF15 MN Glycogen phosphorylase (PYG) DM8KF15 MT DTT DM8KF15 MA Inhibitor DM8KF15 RN Glycogen phosphorylase inhibitors: a patent review (2013 - 2015).Expert Opin Ther Pat. 2016;26(2):199-212. DM8KF15 RU https://www.ncbi.nlm.nih.gov/pubmed/26666989 DMB4SH8 DI DMB4SH8 DMB4SH8 DN PMID26666989-Compound-Figure9middle10 DMB4SH8 MI TT8BUGW DMB4SH8 MN Glycogen phosphorylase (PYG) DMB4SH8 MT DTT DMB4SH8 MA Inhibitor DMB4SH8 RN Glycogen phosphorylase inhibitors: a patent review (2013 - 2015).Expert Opin Ther Pat. 2016;26(2):199-212. DMB4SH8 RU https://www.ncbi.nlm.nih.gov/pubmed/26666989 DMT6CNM DI DMT6CNM DMT6CNM DN PMID26666989-Compound-Figure9middle11 DMT6CNM MI TT8BUGW DMT6CNM MN Glycogen phosphorylase (PYG) DMT6CNM MT DTT DMT6CNM MA Inhibitor DMT6CNM RN Glycogen phosphorylase inhibitors: a patent review (2013 - 2015).Expert Opin Ther Pat. 2016;26(2):199-212. DMT6CNM RU https://www.ncbi.nlm.nih.gov/pubmed/26666989 DMX612V DI DMX612V DMX612V DN PMID26666989-Compound-Figure9middle12 DMX612V MI TT8BUGW DMX612V MN Glycogen phosphorylase (PYG) DMX612V MT DTT DMX612V MA Inhibitor DMX612V RN Glycogen phosphorylase inhibitors: a patent review (2013 - 2015).Expert Opin Ther Pat. 2016;26(2):199-212. DMX612V RU https://www.ncbi.nlm.nih.gov/pubmed/26666989 DMKZTVR DI DMKZTVR DMKZTVR DN PMID26666989-Compound-Figure9middle13 DMKZTVR MI TT8BUGW DMKZTVR MN Glycogen phosphorylase (PYG) DMKZTVR MT DTT DMKZTVR MA Inhibitor DMKZTVR RN Glycogen phosphorylase inhibitors: a patent review (2013 - 2015).Expert Opin Ther Pat. 2016;26(2):199-212. DMKZTVR RU https://www.ncbi.nlm.nih.gov/pubmed/26666989 DMVS1TU DI DMVS1TU DMVS1TU DN PMID26666989-Compound-Figure9topright01 DMVS1TU MI TT8BUGW DMVS1TU MN Glycogen phosphorylase (PYG) DMVS1TU MT DTT DMVS1TU MA Inhibitor DMVS1TU RN Glycogen phosphorylase inhibitors: a patent review (2013 - 2015).Expert Opin Ther Pat. 2016;26(2):199-212. DMVS1TU RU https://www.ncbi.nlm.nih.gov/pubmed/26666989 DMJ3GX6 DI DMJ3GX6 DMJ3GX6 DN PMID26666989-Compound-Figure9toprightR02 DMJ3GX6 MI TT8BUGW DMJ3GX6 MN Glycogen phosphorylase (PYG) DMJ3GX6 MT DTT DMJ3GX6 MA Inhibitor DMJ3GX6 RN Glycogen phosphorylase inhibitors: a patent review (2013 - 2015).Expert Opin Ther Pat. 2016;26(2):199-212. DMJ3GX6 RU https://www.ncbi.nlm.nih.gov/pubmed/26666989 DMOJ936 DI DMOJ936 DMOJ936 DN PMID26815044-Compound-114 DMOJ936 MI TTULVH8 DMOJ936 MN Tyrosinase (TYR) DMOJ936 MT DTT DMOJ936 MA Inhibitor DMOJ936 RN Tyrosinase inhibitors: a patent review (2011-2015).Expert Opin Ther Pat. 2016;26(3):347-62. DMOJ936 RU https://www.ncbi.nlm.nih.gov/pubmed/26815044 DM8SWHO DI DM8SWHO DM8SWHO DN PMID26815044-Compound-115 DM8SWHO MI TTULVH8 DM8SWHO MN Tyrosinase (TYR) DM8SWHO MT DTT DM8SWHO MA Inhibitor DM8SWHO RN Tyrosinase inhibitors: a patent review (2011-2015).Expert Opin Ther Pat. 2016;26(3):347-62. DM8SWHO RU https://www.ncbi.nlm.nih.gov/pubmed/26815044 DMDUXRT DI DMDUXRT DMDUXRT DN PMID26815044-Compound-116 DMDUXRT MI TTULVH8 DMDUXRT MN Tyrosinase (TYR) DMDUXRT MT DTT DMDUXRT MA Inhibitor DMDUXRT RN Tyrosinase inhibitors: a patent review (2011-2015).Expert Opin Ther Pat. 2016;26(3):347-62. DMDUXRT RU https://www.ncbi.nlm.nih.gov/pubmed/26815044 DM2GON6 DI DM2GON6 DM2GON6 DN PMID26815044-Compound-117 DM2GON6 MI TTULVH8 DM2GON6 MN Tyrosinase (TYR) DM2GON6 MT DTT DM2GON6 MA Inhibitor DM2GON6 RN Tyrosinase inhibitors: a patent review (2011-2015).Expert Opin Ther Pat. 2016;26(3):347-62. DM2GON6 RU https://www.ncbi.nlm.nih.gov/pubmed/26815044 DMC28VB DI DMC28VB DMC28VB DN PMID26815044-Compound-118 DMC28VB MI TTULVH8 DMC28VB MN Tyrosinase (TYR) DMC28VB MT DTT DMC28VB MA Inhibitor DMC28VB RN Tyrosinase inhibitors: a patent review (2011-2015).Expert Opin Ther Pat. 2016;26(3):347-62. DMC28VB RU https://www.ncbi.nlm.nih.gov/pubmed/26815044 DMMNXA1 DI DMMNXA1 DMMNXA1 DN PMID26815044-Compound-121 DMMNXA1 MI TTULVH8 DMMNXA1 MN Tyrosinase (TYR) DMMNXA1 MT DTT DMMNXA1 MA Inhibitor DMMNXA1 RN Tyrosinase inhibitors: a patent review (2011-2015).Expert Opin Ther Pat. 2016;26(3):347-62. DMMNXA1 RU https://www.ncbi.nlm.nih.gov/pubmed/26815044 DM1HAGJ DI DM1HAGJ DM1HAGJ DN PMID26815044-Compound-122 DM1HAGJ MI TTULVH8 DM1HAGJ MN Tyrosinase (TYR) DM1HAGJ MT DTT DM1HAGJ MA Inhibitor DM1HAGJ RN Tyrosinase inhibitors: a patent review (2011-2015).Expert Opin Ther Pat. 2016;26(3):347-62. DM1HAGJ RU https://www.ncbi.nlm.nih.gov/pubmed/26815044 DMFTE3Y DI DMFTE3Y DMFTE3Y DN PMID26815044-Compound-123 DMFTE3Y MI TTULVH8 DMFTE3Y MN Tyrosinase (TYR) DMFTE3Y MT DTT DMFTE3Y MA Inhibitor DMFTE3Y RN Tyrosinase inhibitors: a patent review (2011-2015).Expert Opin Ther Pat. 2016;26(3):347-62. DMFTE3Y RU https://www.ncbi.nlm.nih.gov/pubmed/26815044 DM25WGP DI DM25WGP DM25WGP DN PMID26815044-Compound-124 DM25WGP MI TTULVH8 DM25WGP MN Tyrosinase (TYR) DM25WGP MT DTT DM25WGP MA Inhibitor DM25WGP RN Tyrosinase inhibitors: a patent review (2011-2015).Expert Opin Ther Pat. 2016;26(3):347-62. DM25WGP RU https://www.ncbi.nlm.nih.gov/pubmed/26815044 DM6EFIN DI DM6EFIN DM6EFIN DN PMID26815044-Compound-125 DM6EFIN MI TTULVH8 DM6EFIN MN Tyrosinase (TYR) DM6EFIN MT DTT DM6EFIN MA Inhibitor DM6EFIN RN Tyrosinase inhibitors: a patent review (2011-2015).Expert Opin Ther Pat. 2016;26(3):347-62. DM6EFIN RU https://www.ncbi.nlm.nih.gov/pubmed/26815044 DMMJK0L DI DMMJK0L DMMJK0L DN PMID26815044-Compound-126 DMMJK0L MI TTULVH8 DMMJK0L MN Tyrosinase (TYR) DMMJK0L MT DTT DMMJK0L MA Inhibitor DMMJK0L RN Tyrosinase inhibitors: a patent review (2011-2015).Expert Opin Ther Pat. 2016;26(3):347-62. DMMJK0L RU https://www.ncbi.nlm.nih.gov/pubmed/26815044 DMO97LR DI DMO97LR DMO97LR DN PMID26815044-Compound-127 DMO97LR MI TTULVH8 DMO97LR MN Tyrosinase (TYR) DMO97LR MT DTT DMO97LR MA Inhibitor DMO97LR RN Tyrosinase inhibitors: a patent review (2011-2015).Expert Opin Ther Pat. 2016;26(3):347-62. DMO97LR RU https://www.ncbi.nlm.nih.gov/pubmed/26815044 DMH8E7S DI DMH8E7S DMH8E7S DN PMID26815044-Compound-30 DMH8E7S MI TTULVH8 DMH8E7S MN Tyrosinase (TYR) DMH8E7S MT DTT DMH8E7S MA Inhibitor DMH8E7S RN Tyrosinase inhibitors: a patent review (2011-2015).Expert Opin Ther Pat. 2016;26(3):347-62. DMH8E7S RU https://www.ncbi.nlm.nih.gov/pubmed/26815044 DMBINQ9 DI DMBINQ9 DMBINQ9 DN PMID26815044-Compound-31 DMBINQ9 MI TTULVH8 DMBINQ9 MN Tyrosinase (TYR) DMBINQ9 MT DTT DMBINQ9 MA Inhibitor DMBINQ9 RN Tyrosinase inhibitors: a patent review (2011-2015).Expert Opin Ther Pat. 2016;26(3):347-62. DMBINQ9 RU https://www.ncbi.nlm.nih.gov/pubmed/26815044 DMN5H3C DI DMN5H3C DMN5H3C DN PMID26815044-Compound-32 DMN5H3C MI TTULVH8 DMN5H3C MN Tyrosinase (TYR) DMN5H3C MT DTT DMN5H3C MA Inhibitor DMN5H3C RN Tyrosinase inhibitors: a patent review (2011-2015).Expert Opin Ther Pat. 2016;26(3):347-62. DMN5H3C RU https://www.ncbi.nlm.nih.gov/pubmed/26815044 DMM3FJO DI DMM3FJO DMM3FJO DN PMID26815044-Compound-47 DMM3FJO MI TTULVH8 DMM3FJO MN Tyrosinase (TYR) DMM3FJO MT DTT DMM3FJO MA Inhibitor DMM3FJO RN Tyrosinase inhibitors: a patent review (2011-2015).Expert Opin Ther Pat. 2016;26(3):347-62. DMM3FJO RU https://www.ncbi.nlm.nih.gov/pubmed/26815044 DMJ1Z7U DI DMJ1Z7U DMJ1Z7U DN PMID26815044-Compound-48 DMJ1Z7U MI TTULVH8 DMJ1Z7U MN Tyrosinase (TYR) DMJ1Z7U MT DTT DMJ1Z7U MA Inhibitor DMJ1Z7U RN Tyrosinase inhibitors: a patent review (2011-2015).Expert Opin Ther Pat. 2016;26(3):347-62. DMJ1Z7U RU https://www.ncbi.nlm.nih.gov/pubmed/26815044 DMD9WRS DI DMD9WRS DMD9WRS DN PMID26815044-Compound-49 DMD9WRS MI TTULVH8 DMD9WRS MN Tyrosinase (TYR) DMD9WRS MT DTT DMD9WRS MA Inhibitor DMD9WRS RN Tyrosinase inhibitors: a patent review (2011-2015).Expert Opin Ther Pat. 2016;26(3):347-62. DMD9WRS RU https://www.ncbi.nlm.nih.gov/pubmed/26815044 DMYI1SX DI DMYI1SX DMYI1SX DN PMID26815044-Compound-50 DMYI1SX MI TTULVH8 DMYI1SX MN Tyrosinase (TYR) DMYI1SX MT DTT DMYI1SX MA Inhibitor DMYI1SX RN Tyrosinase inhibitors: a patent review (2011-2015).Expert Opin Ther Pat. 2016;26(3):347-62. DMYI1SX RU https://www.ncbi.nlm.nih.gov/pubmed/26815044 DMQGTJ5 DI DMQGTJ5 DMQGTJ5 DN PMID26815044-Compound-51 DMQGTJ5 MI TTULVH8 DMQGTJ5 MN Tyrosinase (TYR) DMQGTJ5 MT DTT DMQGTJ5 MA Inhibitor DMQGTJ5 RN Tyrosinase inhibitors: a patent review (2011-2015).Expert Opin Ther Pat. 2016;26(3):347-62. DMQGTJ5 RU https://www.ncbi.nlm.nih.gov/pubmed/26815044 DMN4C2O DI DMN4C2O DMN4C2O DN PMID26815044-Compound-52 DMN4C2O MI TTULVH8 DMN4C2O MN Tyrosinase (TYR) DMN4C2O MT DTT DMN4C2O MA Inhibitor DMN4C2O RN Tyrosinase inhibitors: a patent review (2011-2015).Expert Opin Ther Pat. 2016;26(3):347-62. DMN4C2O RU https://www.ncbi.nlm.nih.gov/pubmed/26815044 DMEKBOG DI DMEKBOG DMEKBOG DN PMID26815044-Compound-64 DMEKBOG MI TTULVH8 DMEKBOG MN Tyrosinase (TYR) DMEKBOG MT DTT DMEKBOG MA Inhibitor DMEKBOG RN Tyrosinase inhibitors: a patent review (2011-2015).Expert Opin Ther Pat. 2016;26(3):347-62. DMEKBOG RU https://www.ncbi.nlm.nih.gov/pubmed/26815044 DMV46DG DI DMV46DG DMV46DG DN PMID26815044-Compound-93 DMV46DG MI TTULVH8 DMV46DG MN Tyrosinase (TYR) DMV46DG MT DTT DMV46DG MA Inhibitor DMV46DG RN Tyrosinase inhibitors: a patent review (2011-2015).Expert Opin Ther Pat. 2016;26(3):347-62. DMV46DG RU https://www.ncbi.nlm.nih.gov/pubmed/26815044 DMI3QLT DI DMI3QLT DMI3QLT DN PMID26815044-Compound-H DMI3QLT MI TTULVH8 DMI3QLT MN Tyrosinase (TYR) DMI3QLT MT DTT DMI3QLT MA Inhibitor DMI3QLT RN Tyrosinase inhibitors: a patent review (2011-2015).Expert Opin Ther Pat. 2016;26(3):347-62. DMI3QLT RU https://www.ncbi.nlm.nih.gov/pubmed/26815044 DMZISDR DI DMZISDR DMZISDR DN PMID26815044-Compound-I DMZISDR MI TTULVH8 DMZISDR MN Tyrosinase (TYR) DMZISDR MT DTT DMZISDR MA Inhibitor DMZISDR RN Tyrosinase inhibitors: a patent review (2011-2015).Expert Opin Ther Pat. 2016;26(3):347-62. DMZISDR RU https://www.ncbi.nlm.nih.gov/pubmed/26815044 DMPAE8N DI DMPAE8N DMPAE8N DN PMID26882240-Compound-1 DMPAE8N MI TT9MZCQ DMPAE8N MN Enhancer of zeste homolog 2 (EZH2) DMPAE8N MT DTT DMPAE8N MA Inhibitor DMPAE8N RN Hypoxia-inducible factor (HIF) inhibitors: a patent survey (2011-2015).Expert Opin Ther Pat. 2016;26(3):309-22. DMPAE8N RU https://www.ncbi.nlm.nih.gov/pubmed/26882240 DMPAE8N DI DMPAE8N DMPAE8N DN PMID26882240-Compound-1 DMPAE8N MI TTUX68I DMPAE8N MN Hypoxia-inducible factor 1 (HIF-1) DMPAE8N MT DTT DMPAE8N MA Inhibitor DMPAE8N RN Hypoxia-inducible factor (HIF) inhibitors: a patent survey (2011-2015).Expert Opin Ther Pat. 2016;26(3):309-22. DMPAE8N RU https://www.ncbi.nlm.nih.gov/pubmed/26882240 DMQVZ01 DI DMQVZ01 DMQVZ01 DN PMID26882240-Compound-14 DMQVZ01 MI TTUX68I DMQVZ01 MN Hypoxia-inducible factor 1 (HIF-1) DMQVZ01 MT DTT DMQVZ01 MA Inhibitor DMQVZ01 RN Hypoxia-inducible factor (HIF) inhibitors: a patent survey (2011-2015).Expert Opin Ther Pat. 2016;26(3):309-22. DMQVZ01 RU https://www.ncbi.nlm.nih.gov/pubmed/26882240 DMZ12V4 DI DMZ12V4 DMZ12V4 DN PMID26882240-Compound-15 DMZ12V4 MI TTUX68I DMZ12V4 MN Hypoxia-inducible factor 1 (HIF-1) DMZ12V4 MT DTT DMZ12V4 MA Inhibitor DMZ12V4 RN Hypoxia-inducible factor (HIF) inhibitors: a patent survey (2011-2015).Expert Opin Ther Pat. 2016;26(3):309-22. DMZ12V4 RU https://www.ncbi.nlm.nih.gov/pubmed/26882240 DMX7Y52 DI DMX7Y52 DMX7Y52 DN PMID26882240-Compound-2 DMX7Y52 MI TTUX68I DMX7Y52 MN Hypoxia-inducible factor 1 (HIF-1) DMX7Y52 MT DTT DMX7Y52 MA Inhibitor DMX7Y52 RN Hypoxia-inducible factor (HIF) inhibitors: a patent survey (2011-2015).Expert Opin Ther Pat. 2016;26(3):309-22. DMX7Y52 RU https://www.ncbi.nlm.nih.gov/pubmed/26882240 DMFZM3X DI DMFZM3X DMFZM3X DN PMID26882240-Compound-3 DMFZM3X MI TTUX68I DMFZM3X MN Hypoxia-inducible factor 1 (HIF-1) DMFZM3X MT DTT DMFZM3X MA Inhibitor DMFZM3X RN Hypoxia-inducible factor (HIF) inhibitors: a patent survey (2011-2015).Expert Opin Ther Pat. 2016;26(3):309-22. DMFZM3X RU https://www.ncbi.nlm.nih.gov/pubmed/26882240 DMJS4RP DI DMJS4RP DMJS4RP DN PMID26882240-Compound-32 DMJS4RP MI TTUX68I DMJS4RP MN Hypoxia-inducible factor 1 (HIF-1) DMJS4RP MT DTT DMJS4RP MA Inhibitor DMJS4RP RN Hypoxia-inducible factor (HIF) inhibitors: a patent survey (2011-2015).Expert Opin Ther Pat. 2016;26(3):309-22. DMJS4RP RU https://www.ncbi.nlm.nih.gov/pubmed/26882240 DMS4RLZ DI DMS4RLZ DMS4RLZ DN PMID26882240-Compound-4 DMS4RLZ MI TTUX68I DMS4RLZ MN Hypoxia-inducible factor 1 (HIF-1) DMS4RLZ MT DTT DMS4RLZ MA Inhibitor DMS4RLZ RN Hypoxia-inducible factor (HIF) inhibitors: a patent survey (2011-2015).Expert Opin Ther Pat. 2016;26(3):309-22. DMS4RLZ RU https://www.ncbi.nlm.nih.gov/pubmed/26882240 DM61NOP DI DM61NOP DM61NOP DN PMID26882240-Compound-6 DM61NOP MI TTUX68I DM61NOP MN Hypoxia-inducible factor 1 (HIF-1) DM61NOP MT DTT DM61NOP MA Inhibitor DM61NOP RN Hypoxia-inducible factor (HIF) inhibitors: a patent survey (2011-2015).Expert Opin Ther Pat. 2016;26(3):309-22. DM61NOP RU https://www.ncbi.nlm.nih.gov/pubmed/26882240 DMOX8E3 DI DMOX8E3 DMOX8E3 DN PMID26882240-Compound-7 DMOX8E3 MI TTUX68I DMOX8E3 MN Hypoxia-inducible factor 1 (HIF-1) DMOX8E3 MT DTT DMOX8E3 MA Inhibitor DMOX8E3 RN Hypoxia-inducible factor (HIF) inhibitors: a patent survey (2011-2015).Expert Opin Ther Pat. 2016;26(3):309-22. DMOX8E3 RU https://www.ncbi.nlm.nih.gov/pubmed/26882240 DMWJRY7 DI DMWJRY7 DMWJRY7 DN PMID26882240-Compound-8 DMWJRY7 MI TTUX68I DMWJRY7 MN Hypoxia-inducible factor 1 (HIF-1) DMWJRY7 MT DTT DMWJRY7 MA Inhibitor DMWJRY7 RN Hypoxia-inducible factor (HIF) inhibitors: a patent survey (2011-2015).Expert Opin Ther Pat. 2016;26(3):309-22. DMWJRY7 RU https://www.ncbi.nlm.nih.gov/pubmed/26882240 DMEJ107 DI DMEJ107 DMEJ107 DN PMID26924192-Compound-102 DMEJ107 MI TT7CPI5 DMEJ107 MN Bromodomain testis-specific protein (BRDT) DMEJ107 MT DTT DMEJ107 MA Inhibitor DMEJ107 RN BET inhibitors in cancer therapeutics: a patent review.Expert Opin Ther Pat. 2016;26(4):505-22. DMEJ107 RU https://www.ncbi.nlm.nih.gov/pubmed/26924192 DMEJ107 DI DMEJ107 DMEJ107 DN PMID26924192-Compound-102 DMEJ107 MI TTDP48B DMEJ107 MN Bromodomain-containing protein 2 (BRD2) DMEJ107 MT DTT DMEJ107 MA Inhibitor DMEJ107 RN BET inhibitors in cancer therapeutics: a patent review.Expert Opin Ther Pat. 2016;26(4):505-22. DMEJ107 RU https://www.ncbi.nlm.nih.gov/pubmed/26924192 DMEJ107 DI DMEJ107 DMEJ107 DN PMID26924192-Compound-102 DMEJ107 MI TTHE657 DMEJ107 MN Bromodomain-containing protein 3 (BRD3) DMEJ107 MT DTT DMEJ107 MA Inhibitor DMEJ107 RN BET inhibitors in cancer therapeutics: a patent review.Expert Opin Ther Pat. 2016;26(4):505-22. DMEJ107 RU https://www.ncbi.nlm.nih.gov/pubmed/26924192 DMEJ107 DI DMEJ107 DMEJ107 DN PMID26924192-Compound-102 DMEJ107 MI TTRA6BO DMEJ107 MN Bromodomain-containing protein 4 (BRD4) DMEJ107 MT DTT DMEJ107 MA Inhibitor DMEJ107 RN BET inhibitors in cancer therapeutics: a patent review.Expert Opin Ther Pat. 2016;26(4):505-22. DMEJ107 RU https://www.ncbi.nlm.nih.gov/pubmed/26924192 DMWOCP7 DI DMWOCP7 DMWOCP7 DN PMID26924192-Compound-103 DMWOCP7 MI TT7CPI5 DMWOCP7 MN Bromodomain testis-specific protein (BRDT) DMWOCP7 MT DTT DMWOCP7 MA Inhibitor DMWOCP7 RN BET inhibitors in cancer therapeutics: a patent review.Expert Opin Ther Pat. 2016;26(4):505-22. DMWOCP7 RU https://www.ncbi.nlm.nih.gov/pubmed/26924192 DMWOCP7 DI DMWOCP7 DMWOCP7 DN PMID26924192-Compound-103 DMWOCP7 MI TTDP48B DMWOCP7 MN Bromodomain-containing protein 2 (BRD2) DMWOCP7 MT DTT DMWOCP7 MA Inhibitor DMWOCP7 RN BET inhibitors in cancer therapeutics: a patent review.Expert Opin Ther Pat. 2016;26(4):505-22. DMWOCP7 RU https://www.ncbi.nlm.nih.gov/pubmed/26924192 DMWOCP7 DI DMWOCP7 DMWOCP7 DN PMID26924192-Compound-103 DMWOCP7 MI TTHE657 DMWOCP7 MN Bromodomain-containing protein 3 (BRD3) DMWOCP7 MT DTT DMWOCP7 MA Inhibitor DMWOCP7 RN BET inhibitors in cancer therapeutics: a patent review.Expert Opin Ther Pat. 2016;26(4):505-22. DMWOCP7 RU https://www.ncbi.nlm.nih.gov/pubmed/26924192 DMWOCP7 DI DMWOCP7 DMWOCP7 DN PMID26924192-Compound-103 DMWOCP7 MI TTRA6BO DMWOCP7 MN Bromodomain-containing protein 4 (BRD4) DMWOCP7 MT DTT DMWOCP7 MA Inhibitor DMWOCP7 RN BET inhibitors in cancer therapeutics: a patent review.Expert Opin Ther Pat. 2016;26(4):505-22. DMWOCP7 RU https://www.ncbi.nlm.nih.gov/pubmed/26924192 DM346EU DI DM346EU DM346EU DN PMID26924192-Compound-104 DM346EU MI TT7CPI5 DM346EU MN Bromodomain testis-specific protein (BRDT) DM346EU MT DTT DM346EU MA Inhibitor DM346EU RN BET inhibitors in cancer therapeutics: a patent review.Expert Opin Ther Pat. 2016;26(4):505-22. DM346EU RU https://www.ncbi.nlm.nih.gov/pubmed/26924192 DM346EU DI DM346EU DM346EU DN PMID26924192-Compound-104 DM346EU MI TTDP48B DM346EU MN Bromodomain-containing protein 2 (BRD2) DM346EU MT DTT DM346EU MA Inhibitor DM346EU RN BET inhibitors in cancer therapeutics: a patent review.Expert Opin Ther Pat. 2016;26(4):505-22. DM346EU RU https://www.ncbi.nlm.nih.gov/pubmed/26924192 DM346EU DI DM346EU DM346EU DN PMID26924192-Compound-104 DM346EU MI TTHE657 DM346EU MN Bromodomain-containing protein 3 (BRD3) DM346EU MT DTT DM346EU MA Inhibitor DM346EU RN BET inhibitors in cancer therapeutics: a patent review.Expert Opin Ther Pat. 2016;26(4):505-22. DM346EU RU https://www.ncbi.nlm.nih.gov/pubmed/26924192 DM346EU DI DM346EU DM346EU DN PMID26924192-Compound-104 DM346EU MI TTRA6BO DM346EU MN Bromodomain-containing protein 4 (BRD4) DM346EU MT DTT DM346EU MA Inhibitor DM346EU RN BET inhibitors in cancer therapeutics: a patent review.Expert Opin Ther Pat. 2016;26(4):505-22. DM346EU RU https://www.ncbi.nlm.nih.gov/pubmed/26924192 DMAWLGI DI DMAWLGI DMAWLGI DN PMID26924192-Compound-105 DMAWLGI MI TT7CPI5 DMAWLGI MN Bromodomain testis-specific protein (BRDT) DMAWLGI MT DTT DMAWLGI MA Inhibitor DMAWLGI RN BET inhibitors in cancer therapeutics: a patent review.Expert Opin Ther Pat. 2016;26(4):505-22. DMAWLGI RU https://www.ncbi.nlm.nih.gov/pubmed/26924192 DMAWLGI DI DMAWLGI DMAWLGI DN PMID26924192-Compound-105 DMAWLGI MI TTDP48B DMAWLGI MN Bromodomain-containing protein 2 (BRD2) DMAWLGI MT DTT DMAWLGI MA Inhibitor DMAWLGI RN BET inhibitors in cancer therapeutics: a patent review.Expert Opin Ther Pat. 2016;26(4):505-22. DMAWLGI RU https://www.ncbi.nlm.nih.gov/pubmed/26924192 DMAWLGI DI DMAWLGI DMAWLGI DN PMID26924192-Compound-105 DMAWLGI MI TTHE657 DMAWLGI MN Bromodomain-containing protein 3 (BRD3) DMAWLGI MT DTT DMAWLGI MA Inhibitor DMAWLGI RN BET inhibitors in cancer therapeutics: a patent review.Expert Opin Ther Pat. 2016;26(4):505-22. DMAWLGI RU https://www.ncbi.nlm.nih.gov/pubmed/26924192 DMAWLGI DI DMAWLGI DMAWLGI DN PMID26924192-Compound-105 DMAWLGI MI TTRA6BO DMAWLGI MN Bromodomain-containing protein 4 (BRD4) DMAWLGI MT DTT DMAWLGI MA Inhibitor DMAWLGI RN BET inhibitors in cancer therapeutics: a patent review.Expert Opin Ther Pat. 2016;26(4):505-22. DMAWLGI RU https://www.ncbi.nlm.nih.gov/pubmed/26924192 DM9HRZJ DI DM9HRZJ DM9HRZJ DN PMID26924192-Compound-106 DM9HRZJ MI TTDP48B DM9HRZJ MN Bromodomain-containing protein 2 (BRD2) DM9HRZJ MT DTT DM9HRZJ MA Inhibitor DM9HRZJ RN BET inhibitors in cancer therapeutics: a patent review.Expert Opin Ther Pat. 2016;26(4):505-22. DM9HRZJ RU https://www.ncbi.nlm.nih.gov/pubmed/26924192 DMHAOF1 DI DMHAOF1 DMHAOF1 DN PMID26924192-Compound-20 DMHAOF1 MI TTRA6BO DMHAOF1 MN Bromodomain-containing protein 4 (BRD4) DMHAOF1 MT DTT DMHAOF1 MA Inhibitor DMHAOF1 RN BET inhibitors in cancer therapeutics: a patent review.Expert Opin Ther Pat. 2016;26(4):505-22. DMHAOF1 RU https://www.ncbi.nlm.nih.gov/pubmed/26924192 DM4MZ29 DI DM4MZ29 DM4MZ29 DN PMID26924192-Compound-21 DM4MZ29 MI TTRA6BO DM4MZ29 MN Bromodomain-containing protein 4 (BRD4) DM4MZ29 MT DTT DM4MZ29 MA Inhibitor DM4MZ29 RN BET inhibitors in cancer therapeutics: a patent review.Expert Opin Ther Pat. 2016;26(4):505-22. DM4MZ29 RU https://www.ncbi.nlm.nih.gov/pubmed/26924192 DMX964E DI DMX964E DMX964E DN PMID26924192-Compound-22 DMX964E MI TTRA6BO DMX964E MN Bromodomain-containing protein 4 (BRD4) DMX964E MT DTT DMX964E MA Inhibitor DMX964E RN BET inhibitors in cancer therapeutics: a patent review.Expert Opin Ther Pat. 2016;26(4):505-22. DMX964E RU https://www.ncbi.nlm.nih.gov/pubmed/26924192 DME60LY DI DME60LY DME60LY DN PMID26924192-Compound-23 DME60LY MI TTRA6BO DME60LY MN Bromodomain-containing protein 4 (BRD4) DME60LY MT DTT DME60LY MA Inhibitor DME60LY RN BET inhibitors in cancer therapeutics: a patent review.Expert Opin Ther Pat. 2016;26(4):505-22. DME60LY RU https://www.ncbi.nlm.nih.gov/pubmed/26924192 DMDN5Q4 DI DMDN5Q4 DMDN5Q4 DN PMID26924192-Compound-24 DMDN5Q4 MI TTRA6BO DMDN5Q4 MN Bromodomain-containing protein 4 (BRD4) DMDN5Q4 MT DTT DMDN5Q4 MA Inhibitor DMDN5Q4 RN BET inhibitors in cancer therapeutics: a patent review.Expert Opin Ther Pat. 2016;26(4):505-22. DMDN5Q4 RU https://www.ncbi.nlm.nih.gov/pubmed/26924192 DMEL7XA DI DMEL7XA DMEL7XA DN PMID26924192-Compound-25 DMEL7XA MI TTRA6BO DMEL7XA MN Bromodomain-containing protein 4 (BRD4) DMEL7XA MT DTT DMEL7XA MA Inhibitor DMEL7XA RN BET inhibitors in cancer therapeutics: a patent review.Expert Opin Ther Pat. 2016;26(4):505-22. DMEL7XA RU https://www.ncbi.nlm.nih.gov/pubmed/26924192 DMWXNIJ DI DMWXNIJ DMWXNIJ DN PMID26924192-Compound-30 DMWXNIJ MI TTRA6BO DMWXNIJ MN Bromodomain-containing protein 4 (BRD4) DMWXNIJ MT DTT DMWXNIJ MA Inhibitor DMWXNIJ RN BET inhibitors in cancer therapeutics: a patent review.Expert Opin Ther Pat. 2016;26(4):505-22. DMWXNIJ RU https://www.ncbi.nlm.nih.gov/pubmed/26924192 DMWXNIJ DI DMWXNIJ DMWXNIJ DN PMID26924192-Compound-30 DMWXNIJ MI TTU6FSC DMWXNIJ MN Extracellular signal-regulated kinase 5 (ERK5) DMWXNIJ MT DTT DMWXNIJ MA Inhibitor DMWXNIJ RN BET inhibitors in cancer therapeutics: a patent review.Expert Opin Ther Pat. 2016;26(4):505-22. DMWXNIJ RU https://www.ncbi.nlm.nih.gov/pubmed/26924192 DMIFV58 DI DMIFV58 DMIFV58 DN PMID26924192-Compound-31 DMIFV58 MI TTRA6BO DMIFV58 MN Bromodomain-containing protein 4 (BRD4) DMIFV58 MT DTT DMIFV58 MA Inhibitor DMIFV58 RN BET inhibitors in cancer therapeutics: a patent review.Expert Opin Ther Pat. 2016;26(4):505-22. DMIFV58 RU https://www.ncbi.nlm.nih.gov/pubmed/26924192 DM0JSOZ DI DM0JSOZ DM0JSOZ DN PMID26924192-Compound-32 DM0JSOZ MI TTRA6BO DM0JSOZ MN Bromodomain-containing protein 4 (BRD4) DM0JSOZ MT DTT DM0JSOZ MA Inhibitor DM0JSOZ RN BET inhibitors in cancer therapeutics: a patent review.Expert Opin Ther Pat. 2016;26(4):505-22. DM0JSOZ RU https://www.ncbi.nlm.nih.gov/pubmed/26924192 DM0JSOZ DI DM0JSOZ DM0JSOZ DN PMID26924192-Compound-32 DM0JSOZ MI TTU6FSC DM0JSOZ MN Extracellular signal-regulated kinase 5 (ERK5) DM0JSOZ MT DTT DM0JSOZ MA Inhibitor DM0JSOZ RN BET inhibitors in cancer therapeutics: a patent review.Expert Opin Ther Pat. 2016;26(4):505-22. DM0JSOZ RU https://www.ncbi.nlm.nih.gov/pubmed/26924192 DM9NWXM DI DM9NWXM DM9NWXM DN PMID26924192-Compound-33 DM9NWXM MI TTRA6BO DM9NWXM MN Bromodomain-containing protein 4 (BRD4) DM9NWXM MT DTT DM9NWXM MA Inhibitor DM9NWXM RN BET inhibitors in cancer therapeutics: a patent review.Expert Opin Ther Pat. 2016;26(4):505-22. DM9NWXM RU https://www.ncbi.nlm.nih.gov/pubmed/26924192 DM9NWXM DI DM9NWXM DM9NWXM DN PMID26924192-Compound-33 DM9NWXM MI TTU6FSC DM9NWXM MN Extracellular signal-regulated kinase 5 (ERK5) DM9NWXM MT DTT DM9NWXM MA Inhibitor DM9NWXM RN BET inhibitors in cancer therapeutics: a patent review.Expert Opin Ther Pat. 2016;26(4):505-22. DM9NWXM RU https://www.ncbi.nlm.nih.gov/pubmed/26924192 DMTVZWM DI DMTVZWM DMTVZWM DN PMID26924192-Compound-50 DMTVZWM MI TTE4BSY DMTVZWM MN Bromodomain and extraterminal domain protein (BET) DMTVZWM MT DTT DMTVZWM MA Inhibitor DMTVZWM RN BET inhibitors in cancer therapeutics: a patent review.Expert Opin Ther Pat. 2016;26(4):505-22. DMTVZWM RU https://www.ncbi.nlm.nih.gov/pubmed/26924192 DMB2MH3 DI DMB2MH3 DMB2MH3 DN PMID26924192-Compound-51 DMB2MH3 MI TTE4BSY DMB2MH3 MN Bromodomain and extraterminal domain protein (BET) DMB2MH3 MT DTT DMB2MH3 MA Inhibitor DMB2MH3 RN BET inhibitors in cancer therapeutics: a patent review.Expert Opin Ther Pat. 2016;26(4):505-22. DMB2MH3 RU https://www.ncbi.nlm.nih.gov/pubmed/26924192 DMFU6JR DI DMFU6JR DMFU6JR DN PMID26924192-Compound-52 DMFU6JR MI TTE4BSY DMFU6JR MN Bromodomain and extraterminal domain protein (BET) DMFU6JR MT DTT DMFU6JR MA Inhibitor DMFU6JR RN BET inhibitors in cancer therapeutics: a patent review.Expert Opin Ther Pat. 2016;26(4):505-22. DMFU6JR RU https://www.ncbi.nlm.nih.gov/pubmed/26924192 DMFN1AR DI DMFN1AR DMFN1AR DN PMID26924192-Compound-53 DMFN1AR MI TTE4BSY DMFN1AR MN Bromodomain and extraterminal domain protein (BET) DMFN1AR MT DTT DMFN1AR MA Inhibitor DMFN1AR RN BET inhibitors in cancer therapeutics: a patent review.Expert Opin Ther Pat. 2016;26(4):505-22. DMFN1AR RU https://www.ncbi.nlm.nih.gov/pubmed/26924192 DMODT8F DI DMODT8F DMODT8F DN PMID26924192-Compound-54 DMODT8F MI TTE4BSY DMODT8F MN Bromodomain and extraterminal domain protein (BET) DMODT8F MT DTT DMODT8F MA Inhibitor DMODT8F RN BET inhibitors in cancer therapeutics: a patent review.Expert Opin Ther Pat. 2016;26(4):505-22. DMODT8F RU https://www.ncbi.nlm.nih.gov/pubmed/26924192 DMGWQVT DI DMGWQVT DMGWQVT DN PMID26924192-Compound-55 DMGWQVT MI TTE4BSY DMGWQVT MN Bromodomain and extraterminal domain protein (BET) DMGWQVT MT DTT DMGWQVT MA Inhibitor DMGWQVT RN BET inhibitors in cancer therapeutics: a patent review.Expert Opin Ther Pat. 2016;26(4):505-22. DMGWQVT RU https://www.ncbi.nlm.nih.gov/pubmed/26924192 DM6YGLT DI DM6YGLT DM6YGLT DN PMID26924192-Compound-56 DM6YGLT MI TTE4BSY DM6YGLT MN Bromodomain and extraterminal domain protein (BET) DM6YGLT MT DTT DM6YGLT MA Inhibitor DM6YGLT RN BET inhibitors in cancer therapeutics: a patent review.Expert Opin Ther Pat. 2016;26(4):505-22. DM6YGLT RU https://www.ncbi.nlm.nih.gov/pubmed/26924192 DM3NXP8 DI DM3NXP8 DM3NXP8 DN PMID26924192-Compound-57 DM3NXP8 MI TTE4BSY DM3NXP8 MN Bromodomain and extraterminal domain protein (BET) DM3NXP8 MT DTT DM3NXP8 MA Inhibitor DM3NXP8 RN BET inhibitors in cancer therapeutics: a patent review.Expert Opin Ther Pat. 2016;26(4):505-22. DM3NXP8 RU https://www.ncbi.nlm.nih.gov/pubmed/26924192 DMXK6LV DI DMXK6LV DMXK6LV DN PMID26936077-Compound-13 DMXK6LV MI TTQR74A DMXK6LV MN Proteinase activated receptor 2 (PAR2) DMXK6LV MT DTT DMXK6LV MA Antagonist DMXK6LV RN Protease activated receptor 2 (PAR2) modulators: a patent review (2010-2015).Expert Opin Ther Pat. 2016;26(4):471-83. DMXK6LV RU https://www.ncbi.nlm.nih.gov/pubmed/26936077 DMIZL8D DI DMIZL8D DMIZL8D DN PMID26936077-Compound-34 DMIZL8D MI TTQR74A DMIZL8D MN Proteinase activated receptor 2 (PAR2) DMIZL8D MT DTT DMIZL8D MA Antagonist DMIZL8D RN Protease activated receptor 2 (PAR2) modulators: a patent review (2010-2015).Expert Opin Ther Pat. 2016;26(4):471-83. DMIZL8D RU https://www.ncbi.nlm.nih.gov/pubmed/26936077 DMD0HAT DI DMD0HAT DMD0HAT DN PMID27019002-Compound-13 DMD0HAT MI TTNR0UQ DMD0HAT MN Lysine-specific histone demethylase 1 (LSD) DMD0HAT MT DTT DMD0HAT MA Inhibitor DMD0HAT RN LSD1 inhibitors: a patent review (2010-2015).Expert Opin Ther Pat. 2016 May;26(5):565-80. DMD0HAT RU https://www.ncbi.nlm.nih.gov/pubmed/27019002 DMZ9T8H DI DMZ9T8H DMZ9T8H DN PMID27019002-Compound-16 DMZ9T8H MI TTNR0UQ DMZ9T8H MN Lysine-specific histone demethylase 1 (LSD) DMZ9T8H MT DTT DMZ9T8H MA Inhibitor DMZ9T8H RN LSD1 inhibitors: a patent review (2010-2015).Expert Opin Ther Pat. 2016 May;26(5):565-80. DMZ9T8H RU https://www.ncbi.nlm.nih.gov/pubmed/27019002 DM7JASU DI DM7JASU DM7JASU DN PMID27019002-Compound-17 DM7JASU MI TTNR0UQ DM7JASU MN Lysine-specific histone demethylase 1 (LSD) DM7JASU MT DTT DM7JASU MA Inhibitor DM7JASU RN LSD1 inhibitors: a patent review (2010-2015).Expert Opin Ther Pat. 2016 May;26(5):565-80. DM7JASU RU https://www.ncbi.nlm.nih.gov/pubmed/27019002 DM7JASU DI DM7JASU DM7JASU DN PMID27019002-Compound-17 DM7JASU MI TT32XQJ DM7JASU MN Monoamine oxidase (MAO) DM7JASU MT DTT DM7JASU MA Inhibitor DM7JASU RN LSD1 inhibitors: a patent review (2010-2015).Expert Opin Ther Pat. 2016 May;26(5):565-80. DM7JASU RU https://www.ncbi.nlm.nih.gov/pubmed/27019002 DMRX748 DI DMRX748 DMRX748 DN PMID27019002-Compound-20a DMRX748 MI TTNR0UQ DMRX748 MN Lysine-specific histone demethylase 1 (LSD) DMRX748 MT DTT DMRX748 MA Inhibitor DMRX748 RN LSD1 inhibitors: a patent review (2010-2015).Expert Opin Ther Pat. 2016 May;26(5):565-80. DMRX748 RU https://www.ncbi.nlm.nih.gov/pubmed/27019002 DMRX748 DI DMRX748 DMRX748 DN PMID27019002-Compound-20a DMRX748 MI TT32XQJ DMRX748 MN Monoamine oxidase (MAO) DMRX748 MT DTT DMRX748 MA Inhibitor DMRX748 RN LSD1 inhibitors: a patent review (2010-2015).Expert Opin Ther Pat. 2016 May;26(5):565-80. DMRX748 RU https://www.ncbi.nlm.nih.gov/pubmed/27019002 DMYRV8I DI DMYRV8I DMYRV8I DN PMID27019002-Compound-20b DMYRV8I MI TTNR0UQ DMYRV8I MN Lysine-specific histone demethylase 1 (LSD) DMYRV8I MT DTT DMYRV8I MA Inhibitor DMYRV8I RN LSD1 inhibitors: a patent review (2010-2015).Expert Opin Ther Pat. 2016 May;26(5):565-80. DMYRV8I RU https://www.ncbi.nlm.nih.gov/pubmed/27019002 DMC6AF2 DI DMC6AF2 DMC6AF2 DN PMID27019002-Compound-21a DMC6AF2 MI TTNR0UQ DMC6AF2 MN Lysine-specific histone demethylase 1 (LSD) DMC6AF2 MT DTT DMC6AF2 MA Inhibitor DMC6AF2 RN LSD1 inhibitors: a patent review (2010-2015).Expert Opin Ther Pat. 2016 May;26(5):565-80. DMC6AF2 RU https://www.ncbi.nlm.nih.gov/pubmed/27019002 DMMC31N DI DMMC31N DMMC31N DN PMID27019002-Compound-21b DMMC31N MI TTZHPB8 DMMC31N MN Lysine-specific demethylase 4A (KDM4A) DMMC31N MT DTT DMMC31N MA Inhibitor DMMC31N RN LSD1 inhibitors: a patent review (2010-2015).Expert Opin Ther Pat. 2016 May;26(5):565-80. DMMC31N RU https://www.ncbi.nlm.nih.gov/pubmed/27019002 DMMC31N DI DMMC31N DMMC31N DN PMID27019002-Compound-21b DMMC31N MI TTNR0UQ DMMC31N MN Lysine-specific histone demethylase 1 (LSD) DMMC31N MT DTT DMMC31N MA Inhibitor DMMC31N RN LSD1 inhibitors: a patent review (2010-2015).Expert Opin Ther Pat. 2016 May;26(5):565-80. DMMC31N RU https://www.ncbi.nlm.nih.gov/pubmed/27019002 DMWZOKP DI DMWZOKP DMWZOKP DN PMID27019002-Compound-21c DMWZOKP MI TTZHPB8 DMWZOKP MN Lysine-specific demethylase 4A (KDM4A) DMWZOKP MT DTT DMWZOKP MA Inhibitor DMWZOKP RN LSD1 inhibitors: a patent review (2010-2015).Expert Opin Ther Pat. 2016 May;26(5):565-80. DMWZOKP RU https://www.ncbi.nlm.nih.gov/pubmed/27019002 DMWZOKP DI DMWZOKP DMWZOKP DN PMID27019002-Compound-21c DMWZOKP MI TTNR0UQ DMWZOKP MN Lysine-specific histone demethylase 1 (LSD) DMWZOKP MT DTT DMWZOKP MA Inhibitor DMWZOKP RN LSD1 inhibitors: a patent review (2010-2015).Expert Opin Ther Pat. 2016 May;26(5):565-80. DMWZOKP RU https://www.ncbi.nlm.nih.gov/pubmed/27019002 DM1R6GA DI DM1R6GA DM1R6GA DN PMID27019002-Compound-28 DM1R6GA MI TTNR0UQ DM1R6GA MN Lysine-specific histone demethylase 1 (LSD) DM1R6GA MT DTT DM1R6GA MA Inhibitor DM1R6GA RN LSD1 inhibitors: a patent review (2010-2015).Expert Opin Ther Pat. 2016 May;26(5):565-80. DM1R6GA RU https://www.ncbi.nlm.nih.gov/pubmed/27019002 DM954C8 DI DM954C8 DM954C8 DN PMID27019002-Compound-28a DM954C8 MI TTNR0UQ DM954C8 MN Lysine-specific histone demethylase 1 (LSD) DM954C8 MT DTT DM954C8 MA Inhibitor DM954C8 RN LSD1 inhibitors: a patent review (2010-2015).Expert Opin Ther Pat. 2016 May;26(5):565-80. DM954C8 RU https://www.ncbi.nlm.nih.gov/pubmed/27019002 DMRWGHN DI DMRWGHN DMRWGHN DN PMID27019002-Compound-31a DMRWGHN MI TTNR0UQ DMRWGHN MN Lysine-specific histone demethylase 1 (LSD) DMRWGHN MT DTT DMRWGHN MA Inhibitor DMRWGHN RN LSD1 inhibitors: a patent review (2010-2015).Expert Opin Ther Pat. 2016 May;26(5):565-80. DMRWGHN RU https://www.ncbi.nlm.nih.gov/pubmed/27019002 DMJ1K4Y DI DMJ1K4Y DMJ1K4Y DN PMID27019002-Compound-31b DMJ1K4Y MI TTNR0UQ DMJ1K4Y MN Lysine-specific histone demethylase 1 (LSD) DMJ1K4Y MT DTT DMJ1K4Y MA Inhibitor DMJ1K4Y RN LSD1 inhibitors: a patent review (2010-2015).Expert Opin Ther Pat. 2016 May;26(5):565-80. DMJ1K4Y RU https://www.ncbi.nlm.nih.gov/pubmed/27019002 DMMB6XC DI DMMB6XC DMMB6XC DN PMID27019002-Compound-37a DMMB6XC MI TTNR0UQ DMMB6XC MN Lysine-specific histone demethylase 1 (LSD) DMMB6XC MT DTT DMMB6XC MA Inhibitor DMMB6XC RN LSD1 inhibitors: a patent review (2010-2015).Expert Opin Ther Pat. 2016 May;26(5):565-80. DMMB6XC RU https://www.ncbi.nlm.nih.gov/pubmed/27019002 DMCIT5A DI DMCIT5A DMCIT5A DN PMID27019002-Compound-37b DMCIT5A MI TTNR0UQ DMCIT5A MN Lysine-specific histone demethylase 1 (LSD) DMCIT5A MT DTT DMCIT5A MA Inhibitor DMCIT5A RN LSD1 inhibitors: a patent review (2010-2015).Expert Opin Ther Pat. 2016 May;26(5):565-80. DMCIT5A RU https://www.ncbi.nlm.nih.gov/pubmed/27019002 DMVLXRB DI DMVLXRB DMVLXRB DN PMID27019002-Compound-41 DMVLXRB MI TTNR0UQ DMVLXRB MN Lysine-specific histone demethylase 1 (LSD) DMVLXRB MT DTT DMVLXRB MA Inhibitor DMVLXRB RN LSD1 inhibitors: a patent review (2010-2015).Expert Opin Ther Pat. 2016 May;26(5):565-80. DMVLXRB RU https://www.ncbi.nlm.nih.gov/pubmed/27019002 DM42VUQ DI DM42VUQ DM42VUQ DN PMID27019002-Compound-42a DM42VUQ MI TTNR0UQ DM42VUQ MN Lysine-specific histone demethylase 1 (LSD) DM42VUQ MT DTT DM42VUQ MA Inhibitor DM42VUQ RN LSD1 inhibitors: a patent review (2010-2015).Expert Opin Ther Pat. 2016 May;26(5):565-80. DM42VUQ RU https://www.ncbi.nlm.nih.gov/pubmed/27019002 DMHJBRO DI DMHJBRO DMHJBRO DN PMID27019002-Compound-42b DMHJBRO MI TTNR0UQ DMHJBRO MN Lysine-specific histone demethylase 1 (LSD) DMHJBRO MT DTT DMHJBRO MA Inhibitor DMHJBRO RN LSD1 inhibitors: a patent review (2010-2015).Expert Opin Ther Pat. 2016 May;26(5):565-80. DMHJBRO RU https://www.ncbi.nlm.nih.gov/pubmed/27019002 DMMOVGU DI DMMOVGU DMMOVGU DN PMID27019002-Compound-43a DMMOVGU MI TTNR0UQ DMMOVGU MN Lysine-specific histone demethylase 1 (LSD) DMMOVGU MT DTT DMMOVGU MA Inhibitor DMMOVGU RN LSD1 inhibitors: a patent review (2010-2015).Expert Opin Ther Pat. 2016 May;26(5):565-80. DMMOVGU RU https://www.ncbi.nlm.nih.gov/pubmed/27019002 DMIMFND DI DMIMFND DMIMFND DN PMID27019002-Compound-43b DMIMFND MI TTNR0UQ DMIMFND MN Lysine-specific histone demethylase 1 (LSD) DMIMFND MT DTT DMIMFND MA Inhibitor DMIMFND RN LSD1 inhibitors: a patent review (2010-2015).Expert Opin Ther Pat. 2016 May;26(5):565-80. DMIMFND RU https://www.ncbi.nlm.nih.gov/pubmed/27019002 DM72TBJ DI DM72TBJ DM72TBJ DN PMID27019002-Compound-43c DM72TBJ MI TTNR0UQ DM72TBJ MN Lysine-specific histone demethylase 1 (LSD) DM72TBJ MT DTT DM72TBJ MA Inhibitor DM72TBJ RN LSD1 inhibitors: a patent review (2010-2015).Expert Opin Ther Pat. 2016 May;26(5):565-80. DM72TBJ RU https://www.ncbi.nlm.nih.gov/pubmed/27019002 DM5HUCR DI DM5HUCR DM5HUCR DN PMID27019002-Compound-44 DM5HUCR MI TTNR0UQ DM5HUCR MN Lysine-specific histone demethylase 1 (LSD) DM5HUCR MT DTT DM5HUCR MA Inhibitor DM5HUCR RN LSD1 inhibitors: a patent review (2010-2015).Expert Opin Ther Pat. 2016 May;26(5):565-80. DM5HUCR RU https://www.ncbi.nlm.nih.gov/pubmed/27019002 DM3G6YV DI DM3G6YV DM3G6YV DN PMID27019002-Compound-45 DM3G6YV MI TTNR0UQ DM3G6YV MN Lysine-specific histone demethylase 1 (LSD) DM3G6YV MT DTT DM3G6YV MA Inhibitor DM3G6YV RN LSD1 inhibitors: a patent review (2010-2015).Expert Opin Ther Pat. 2016 May;26(5):565-80. DM3G6YV RU https://www.ncbi.nlm.nih.gov/pubmed/27019002 DMQPU7K DI DMQPU7K DMQPU7K DN PMID27019002-Compound-46 DMQPU7K MI TTNR0UQ DMQPU7K MN Lysine-specific histone demethylase 1 (LSD) DMQPU7K MT DTT DMQPU7K MA Inhibitor DMQPU7K RN LSD1 inhibitors: a patent review (2010-2015).Expert Opin Ther Pat. 2016 May;26(5):565-80. DMQPU7K RU https://www.ncbi.nlm.nih.gov/pubmed/27019002 DMQPU7K DI DMQPU7K DMQPU7K DN PMID27019002-Compound-46 DMQPU7K MI TT8VP2T DMQPU7K MN Lysine-specific histone demethylase 1B (KDM1B) DMQPU7K MT DTT DMQPU7K MA Inhibitor DMQPU7K RN LSD1 inhibitors: a patent review (2010-2015).Expert Opin Ther Pat. 2016 May;26(5):565-80. DMQPU7K RU https://www.ncbi.nlm.nih.gov/pubmed/27019002 DMRLWP9 DI DMRLWP9 DMRLWP9 DN PMID27019002-Compound-47 DMRLWP9 MI TTNR0UQ DMRLWP9 MN Lysine-specific histone demethylase 1 (LSD) DMRLWP9 MT DTT DMRLWP9 MA Inhibitor DMRLWP9 RN LSD1 inhibitors: a patent review (2010-2015).Expert Opin Ther Pat. 2016 May;26(5):565-80. DMRLWP9 RU https://www.ncbi.nlm.nih.gov/pubmed/27019002 DMRLWP9 DI DMRLWP9 DMRLWP9 DN PMID27019002-Compound-47 DMRLWP9 MI TT8VP2T DMRLWP9 MN Lysine-specific histone demethylase 1B (KDM1B) DMRLWP9 MT DTT DMRLWP9 MA Inhibitor DMRLWP9 RN LSD1 inhibitors: a patent review (2010-2015).Expert Opin Ther Pat. 2016 May;26(5):565-80. DMRLWP9 RU https://www.ncbi.nlm.nih.gov/pubmed/27019002 DMIO8J3 DI DMIO8J3 DMIO8J3 DN PMID27019002-Compound-48 DMIO8J3 MI TTNR0UQ DMIO8J3 MN Lysine-specific histone demethylase 1 (LSD) DMIO8J3 MT DTT DMIO8J3 MA Inhibitor DMIO8J3 RN LSD1 inhibitors: a patent review (2010-2015).Expert Opin Ther Pat. 2016 May;26(5):565-80. DMIO8J3 RU https://www.ncbi.nlm.nih.gov/pubmed/27019002 DMIO8J3 DI DMIO8J3 DMIO8J3 DN PMID27019002-Compound-48 DMIO8J3 MI TT8VP2T DMIO8J3 MN Lysine-specific histone demethylase 1B (KDM1B) DMIO8J3 MT DTT DMIO8J3 MA Inhibitor DMIO8J3 RN LSD1 inhibitors: a patent review (2010-2015).Expert Opin Ther Pat. 2016 May;26(5):565-80. DMIO8J3 RU https://www.ncbi.nlm.nih.gov/pubmed/27019002 DMP6WCX DI DMP6WCX DMP6WCX DN PMID27019002-Compound-49 DMP6WCX MI TTNR0UQ DMP6WCX MN Lysine-specific histone demethylase 1 (LSD) DMP6WCX MT DTT DMP6WCX MA Inhibitor DMP6WCX RN LSD1 inhibitors: a patent review (2010-2015).Expert Opin Ther Pat. 2016 May;26(5):565-80. DMP6WCX RU https://www.ncbi.nlm.nih.gov/pubmed/27019002 DM4D75L DI DM4D75L DM4D75L DN PMID27019002-Compound-50 DM4D75L MI TTNR0UQ DM4D75L MN Lysine-specific histone demethylase 1 (LSD) DM4D75L MT DTT DM4D75L MA Inhibitor DM4D75L RN LSD1 inhibitors: a patent review (2010-2015).Expert Opin Ther Pat. 2016 May;26(5):565-80. DM4D75L RU https://www.ncbi.nlm.nih.gov/pubmed/27019002 DMB0S52 DI DMB0S52 DMB0S52 DN PMID27019002-Compound-7 DMB0S52 MI TTNR0UQ DMB0S52 MN Lysine-specific histone demethylase 1 (LSD) DMB0S52 MT DTT DMB0S52 MA Inhibitor DMB0S52 RN LSD1 inhibitors: a patent review (2010-2015).Expert Opin Ther Pat. 2016 May;26(5):565-80. DMB0S52 RU https://www.ncbi.nlm.nih.gov/pubmed/27019002 DMW2N5D DI DMW2N5D DMW2N5D DN PMID27109571-Compound-1 DMW2N5D MI TTMY6L1 DMW2N5D MN Fatty acid-binding protein (FABP) DMW2N5D MT DTT DMW2N5D MA Inhibitor DMW2N5D RN Fatty acid binding protein (FABP) inhibitors: a patent review (2012-2015).Expert Opin Ther Pat. 2016 Jul;26(7):767-76. DMW2N5D RU https://www.ncbi.nlm.nih.gov/pubmed/27109571 DMW60HU DI DMW60HU DMW60HU DN PMID27109571-Compound-10 DMW60HU MI TTHWMFZ DMW60HU MN Fatty acid-binding protein 4 (FABP4) DMW60HU MT DTT DMW60HU MA Inhibitor DMW60HU RN Fatty acid binding protein (FABP) inhibitors: a patent review (2012-2015).Expert Opin Ther Pat. 2016 Jul;26(7):767-76. DMW60HU RU https://www.ncbi.nlm.nih.gov/pubmed/27109571 DMMI4KQ DI DMMI4KQ DMMI4KQ DN PMID27109571-Compound-11 DMMI4KQ MI TTHWMFZ DMMI4KQ MN Fatty acid-binding protein 4 (FABP4) DMMI4KQ MT DTT DMMI4KQ MA Inhibitor DMMI4KQ RN Fatty acid binding protein (FABP) inhibitors: a patent review (2012-2015).Expert Opin Ther Pat. 2016 Jul;26(7):767-76. DMMI4KQ RU https://www.ncbi.nlm.nih.gov/pubmed/27109571 DM6HWBK DI DM6HWBK DM6HWBK DN PMID27109571-Compound-12 DM6HWBK MI TTHWMFZ DM6HWBK MN Fatty acid-binding protein 4 (FABP4) DM6HWBK MT DTT DM6HWBK MA Inhibitor DM6HWBK RN Fatty acid binding protein (FABP) inhibitors: a patent review (2012-2015).Expert Opin Ther Pat. 2016 Jul;26(7):767-76. DM6HWBK RU https://www.ncbi.nlm.nih.gov/pubmed/27109571 DM6HWBK DI DM6HWBK DM6HWBK DN PMID27109571-Compound-12 DM6HWBK MI TTNT2S6 DM6HWBK MN Fatty acid-binding protein 5 (FABP5) DM6HWBK MT DTT DM6HWBK MA Inhibitor DM6HWBK RN Fatty acid binding protein (FABP) inhibitors: a patent review (2012-2015).Expert Opin Ther Pat. 2016 Jul;26(7):767-76. DM6HWBK RU https://www.ncbi.nlm.nih.gov/pubmed/27109571 DMUKOGJ DI DMUKOGJ DMUKOGJ DN PMID27109571-Compound-13 DMUKOGJ MI TTHWMFZ DMUKOGJ MN Fatty acid-binding protein 4 (FABP4) DMUKOGJ MT DTT DMUKOGJ MA Inhibitor DMUKOGJ RN Fatty acid binding protein (FABP) inhibitors: a patent review (2012-2015).Expert Opin Ther Pat. 2016 Jul;26(7):767-76. DMUKOGJ RU https://www.ncbi.nlm.nih.gov/pubmed/27109571 DMUKOGJ DI DMUKOGJ DMUKOGJ DN PMID27109571-Compound-13 DMUKOGJ MI TTNT2S6 DMUKOGJ MN Fatty acid-binding protein 5 (FABP5) DMUKOGJ MT DTT DMUKOGJ MA Inhibitor DMUKOGJ RN Fatty acid binding protein (FABP) inhibitors: a patent review (2012-2015).Expert Opin Ther Pat. 2016 Jul;26(7):767-76. DMUKOGJ RU https://www.ncbi.nlm.nih.gov/pubmed/27109571 DMVY6B9 DI DMVY6B9 DMVY6B9 DN PMID27109571-Compound-14 DMVY6B9 MI TTHWMFZ DMVY6B9 MN Fatty acid-binding protein 4 (FABP4) DMVY6B9 MT DTT DMVY6B9 MA Inhibitor DMVY6B9 RN Fatty acid binding protein (FABP) inhibitors: a patent review (2012-2015).Expert Opin Ther Pat. 2016 Jul;26(7):767-76. DMVY6B9 RU https://www.ncbi.nlm.nih.gov/pubmed/27109571 DMVY6B9 DI DMVY6B9 DMVY6B9 DN PMID27109571-Compound-14 DMVY6B9 MI TTNT2S6 DMVY6B9 MN Fatty acid-binding protein 5 (FABP5) DMVY6B9 MT DTT DMVY6B9 MA Inhibitor DMVY6B9 RN Fatty acid binding protein (FABP) inhibitors: a patent review (2012-2015).Expert Opin Ther Pat. 2016 Jul;26(7):767-76. DMVY6B9 RU https://www.ncbi.nlm.nih.gov/pubmed/27109571 DMUR3FY DI DMUR3FY DMUR3FY DN PMID27109571-Compound-15 DMUR3FY MI TTHWMFZ DMUR3FY MN Fatty acid-binding protein 4 (FABP4) DMUR3FY MT DTT DMUR3FY MA Inhibitor DMUR3FY RN Fatty acid binding protein (FABP) inhibitors: a patent review (2012-2015).Expert Opin Ther Pat. 2016 Jul;26(7):767-76. DMUR3FY RU https://www.ncbi.nlm.nih.gov/pubmed/27109571 DMUR3FY DI DMUR3FY DMUR3FY DN PMID27109571-Compound-15 DMUR3FY MI TTNT2S6 DMUR3FY MN Fatty acid-binding protein 5 (FABP5) DMUR3FY MT DTT DMUR3FY MA Inhibitor DMUR3FY RN Fatty acid binding protein (FABP) inhibitors: a patent review (2012-2015).Expert Opin Ther Pat. 2016 Jul;26(7):767-76. DMUR3FY RU https://www.ncbi.nlm.nih.gov/pubmed/27109571 DMZI25U DI DMZI25U DMZI25U DN PMID27109571-Compound-16 DMZI25U MI TTHWMFZ DMZI25U MN Fatty acid-binding protein 4 (FABP4) DMZI25U MT DTT DMZI25U MA Inhibitor DMZI25U RN Fatty acid binding protein (FABP) inhibitors: a patent review (2012-2015).Expert Opin Ther Pat. 2016 Jul;26(7):767-76. DMZI25U RU https://www.ncbi.nlm.nih.gov/pubmed/27109571 DMZI25U DI DMZI25U DMZI25U DN PMID27109571-Compound-16 DMZI25U MI TTNT2S6 DMZI25U MN Fatty acid-binding protein 5 (FABP5) DMZI25U MT DTT DMZI25U MA Inhibitor DMZI25U RN Fatty acid binding protein (FABP) inhibitors: a patent review (2012-2015).Expert Opin Ther Pat. 2016 Jul;26(7):767-76. DMZI25U RU https://www.ncbi.nlm.nih.gov/pubmed/27109571 DMBETU6 DI DMBETU6 DMBETU6 DN PMID27109571-Compound-17 DMBETU6 MI TTHWMFZ DMBETU6 MN Fatty acid-binding protein 4 (FABP4) DMBETU6 MT DTT DMBETU6 MA Inhibitor DMBETU6 RN Fatty acid binding protein (FABP) inhibitors: a patent review (2012-2015).Expert Opin Ther Pat. 2016 Jul;26(7):767-76. DMBETU6 RU https://www.ncbi.nlm.nih.gov/pubmed/27109571 DMBETU6 DI DMBETU6 DMBETU6 DN PMID27109571-Compound-17 DMBETU6 MI TTNT2S6 DMBETU6 MN Fatty acid-binding protein 5 (FABP5) DMBETU6 MT DTT DMBETU6 MA Inhibitor DMBETU6 RN Fatty acid binding protein (FABP) inhibitors: a patent review (2012-2015).Expert Opin Ther Pat. 2016 Jul;26(7):767-76. DMBETU6 RU https://www.ncbi.nlm.nih.gov/pubmed/27109571 DM4S5ME DI DM4S5ME DM4S5ME DN PMID27109571-Compound-18 DM4S5ME MI TTHWMFZ DM4S5ME MN Fatty acid-binding protein 4 (FABP4) DM4S5ME MT DTT DM4S5ME MA Inhibitor DM4S5ME RN Fatty acid binding protein (FABP) inhibitors: a patent review (2012-2015).Expert Opin Ther Pat. 2016 Jul;26(7):767-76. DM4S5ME RU https://www.ncbi.nlm.nih.gov/pubmed/27109571 DM4S5ME DI DM4S5ME DM4S5ME DN PMID27109571-Compound-18 DM4S5ME MI TTNT2S6 DM4S5ME MN Fatty acid-binding protein 5 (FABP5) DM4S5ME MT DTT DM4S5ME MA Inhibitor DM4S5ME RN Fatty acid binding protein (FABP) inhibitors: a patent review (2012-2015).Expert Opin Ther Pat. 2016 Jul;26(7):767-76. DM4S5ME RU https://www.ncbi.nlm.nih.gov/pubmed/27109571 DMIJGLB DI DMIJGLB DMIJGLB DN PMID27109571-Compound-19 DMIJGLB MI TTHWMFZ DMIJGLB MN Fatty acid-binding protein 4 (FABP4) DMIJGLB MT DTT DMIJGLB MA Inhibitor DMIJGLB RN Fatty acid binding protein (FABP) inhibitors: a patent review (2012-2015).Expert Opin Ther Pat. 2016 Jul;26(7):767-76. DMIJGLB RU https://www.ncbi.nlm.nih.gov/pubmed/27109571 DMIJGLB DI DMIJGLB DMIJGLB DN PMID27109571-Compound-19 DMIJGLB MI TTNT2S6 DMIJGLB MN Fatty acid-binding protein 5 (FABP5) DMIJGLB MT DTT DMIJGLB MA Inhibitor DMIJGLB RN Fatty acid binding protein (FABP) inhibitors: a patent review (2012-2015).Expert Opin Ther Pat. 2016 Jul;26(7):767-76. DMIJGLB RU https://www.ncbi.nlm.nih.gov/pubmed/27109571 DMTD1X8 DI DMTD1X8 DMTD1X8 DN PMID27109571-Compound-2 DMTD1X8 MI TTMY6L1 DMTD1X8 MN Fatty acid-binding protein (FABP) DMTD1X8 MT DTT DMTD1X8 MA Inhibitor DMTD1X8 RN Fatty acid binding protein (FABP) inhibitors: a patent review (2012-2015).Expert Opin Ther Pat. 2016 Jul;26(7):767-76. DMTD1X8 RU https://www.ncbi.nlm.nih.gov/pubmed/27109571 DMQU9XP DI DMQU9XP DMQU9XP DN PMID27109571-Compound-20 DMQU9XP MI TTHWMFZ DMQU9XP MN Fatty acid-binding protein 4 (FABP4) DMQU9XP MT DTT DMQU9XP MA Inhibitor DMQU9XP RN Fatty acid binding protein (FABP) inhibitors: a patent review (2012-2015).Expert Opin Ther Pat. 2016 Jul;26(7):767-76. DMQU9XP RU https://www.ncbi.nlm.nih.gov/pubmed/27109571 DMQU9XP DI DMQU9XP DMQU9XP DN PMID27109571-Compound-20 DMQU9XP MI TTNT2S6 DMQU9XP MN Fatty acid-binding protein 5 (FABP5) DMQU9XP MT DTT DMQU9XP MA Inhibitor DMQU9XP RN Fatty acid binding protein (FABP) inhibitors: a patent review (2012-2015).Expert Opin Ther Pat. 2016 Jul;26(7):767-76. DMQU9XP RU https://www.ncbi.nlm.nih.gov/pubmed/27109571 DM0R5Y8 DI DM0R5Y8 DM0R5Y8 DN PMID27109571-Compound-21 DM0R5Y8 MI TTHWMFZ DM0R5Y8 MN Fatty acid-binding protein 4 (FABP4) DM0R5Y8 MT DTT DM0R5Y8 MA Inhibitor DM0R5Y8 RN Fatty acid binding protein (FABP) inhibitors: a patent review (2012-2015).Expert Opin Ther Pat. 2016 Jul;26(7):767-76. DM0R5Y8 RU https://www.ncbi.nlm.nih.gov/pubmed/27109571 DM0R5Y8 DI DM0R5Y8 DM0R5Y8 DN PMID27109571-Compound-21 DM0R5Y8 MI TTNT2S6 DM0R5Y8 MN Fatty acid-binding protein 5 (FABP5) DM0R5Y8 MT DTT DM0R5Y8 MA Inhibitor DM0R5Y8 RN Fatty acid binding protein (FABP) inhibitors: a patent review (2012-2015).Expert Opin Ther Pat. 2016 Jul;26(7):767-76. DM0R5Y8 RU https://www.ncbi.nlm.nih.gov/pubmed/27109571 DMC52VP DI DMC52VP DMC52VP DN PMID27109571-Compound-22 DMC52VP MI TTHWMFZ DMC52VP MN Fatty acid-binding protein 4 (FABP4) DMC52VP MT DTT DMC52VP MA Inhibitor DMC52VP RN Fatty acid binding protein (FABP) inhibitors: a patent review (2012-2015).Expert Opin Ther Pat. 2016 Jul;26(7):767-76. DMC52VP RU https://www.ncbi.nlm.nih.gov/pubmed/27109571 DMC52VP DI DMC52VP DMC52VP DN PMID27109571-Compound-22 DMC52VP MI TTNT2S6 DMC52VP MN Fatty acid-binding protein 5 (FABP5) DMC52VP MT DTT DMC52VP MA Inhibitor DMC52VP RN Fatty acid binding protein (FABP) inhibitors: a patent review (2012-2015).Expert Opin Ther Pat. 2016 Jul;26(7):767-76. DMC52VP RU https://www.ncbi.nlm.nih.gov/pubmed/27109571 DML49UI DI DML49UI DML49UI DN PMID27109571-Compound-23 DML49UI MI TTHWMFZ DML49UI MN Fatty acid-binding protein 4 (FABP4) DML49UI MT DTT DML49UI MA Inhibitor DML49UI RN Fatty acid binding protein (FABP) inhibitors: a patent review (2012-2015).Expert Opin Ther Pat. 2016 Jul;26(7):767-76. DML49UI RU https://www.ncbi.nlm.nih.gov/pubmed/27109571 DML49UI DI DML49UI DML49UI DN PMID27109571-Compound-23 DML49UI MI TTNT2S6 DML49UI MN Fatty acid-binding protein 5 (FABP5) DML49UI MT DTT DML49UI MA Inhibitor DML49UI RN Fatty acid binding protein (FABP) inhibitors: a patent review (2012-2015).Expert Opin Ther Pat. 2016 Jul;26(7):767-76. DML49UI RU https://www.ncbi.nlm.nih.gov/pubmed/27109571 DMPHTC0 DI DMPHTC0 DMPHTC0 DN PMID27109571-Compound-24 DMPHTC0 MI TTHWMFZ DMPHTC0 MN Fatty acid-binding protein 4 (FABP4) DMPHTC0 MT DTT DMPHTC0 MA Inhibitor DMPHTC0 RN Fatty acid binding protein (FABP) inhibitors: a patent review (2012-2015).Expert Opin Ther Pat. 2016 Jul;26(7):767-76. DMPHTC0 RU https://www.ncbi.nlm.nih.gov/pubmed/27109571 DMPHTC0 DI DMPHTC0 DMPHTC0 DN PMID27109571-Compound-24 DMPHTC0 MI TTNT2S6 DMPHTC0 MN Fatty acid-binding protein 5 (FABP5) DMPHTC0 MT DTT DMPHTC0 MA Inhibitor DMPHTC0 RN Fatty acid binding protein (FABP) inhibitors: a patent review (2012-2015).Expert Opin Ther Pat. 2016 Jul;26(7):767-76. DMPHTC0 RU https://www.ncbi.nlm.nih.gov/pubmed/27109571 DM435GR DI DM435GR DM435GR DN PMID27109571-Compound-25 DM435GR MI TTHWMFZ DM435GR MN Fatty acid-binding protein 4 (FABP4) DM435GR MT DTT DM435GR MA Inhibitor DM435GR RN Fatty acid binding protein (FABP) inhibitors: a patent review (2012-2015).Expert Opin Ther Pat. 2016 Jul;26(7):767-76. DM435GR RU https://www.ncbi.nlm.nih.gov/pubmed/27109571 DM435GR DI DM435GR DM435GR DN PMID27109571-Compound-25 DM435GR MI TTNT2S6 DM435GR MN Fatty acid-binding protein 5 (FABP5) DM435GR MT DTT DM435GR MA Inhibitor DM435GR RN Fatty acid binding protein (FABP) inhibitors: a patent review (2012-2015).Expert Opin Ther Pat. 2016 Jul;26(7):767-76. DM435GR RU https://www.ncbi.nlm.nih.gov/pubmed/27109571 DMJCL53 DI DMJCL53 DMJCL53 DN PMID27109571-Compound-26 DMJCL53 MI TTHWMFZ DMJCL53 MN Fatty acid-binding protein 4 (FABP4) DMJCL53 MT DTT DMJCL53 MA Inhibitor DMJCL53 RN Fatty acid binding protein (FABP) inhibitors: a patent review (2012-2015).Expert Opin Ther Pat. 2016 Jul;26(7):767-76. DMJCL53 RU https://www.ncbi.nlm.nih.gov/pubmed/27109571 DMJCL53 DI DMJCL53 DMJCL53 DN PMID27109571-Compound-26 DMJCL53 MI TTNT2S6 DMJCL53 MN Fatty acid-binding protein 5 (FABP5) DMJCL53 MT DTT DMJCL53 MA Inhibitor DMJCL53 RN Fatty acid binding protein (FABP) inhibitors: a patent review (2012-2015).Expert Opin Ther Pat. 2016 Jul;26(7):767-76. DMJCL53 RU https://www.ncbi.nlm.nih.gov/pubmed/27109571 DMXRTH4 DI DMXRTH4 DMXRTH4 DN PMID27109571-Compound-27 DMXRTH4 MI TTHWMFZ DMXRTH4 MN Fatty acid-binding protein 4 (FABP4) DMXRTH4 MT DTT DMXRTH4 MA Inhibitor DMXRTH4 RN Fatty acid binding protein (FABP) inhibitors: a patent review (2012-2015).Expert Opin Ther Pat. 2016 Jul;26(7):767-76. DMXRTH4 RU https://www.ncbi.nlm.nih.gov/pubmed/27109571 DMXRTH4 DI DMXRTH4 DMXRTH4 DN PMID27109571-Compound-27 DMXRTH4 MI TTNT2S6 DMXRTH4 MN Fatty acid-binding protein 5 (FABP5) DMXRTH4 MT DTT DMXRTH4 MA Inhibitor DMXRTH4 RN Fatty acid binding protein (FABP) inhibitors: a patent review (2012-2015).Expert Opin Ther Pat. 2016 Jul;26(7):767-76. DMXRTH4 RU https://www.ncbi.nlm.nih.gov/pubmed/27109571 DMTZVY3 DI DMTZVY3 DMTZVY3 DN PMID27109571-Compound-28 DMTZVY3 MI TTHWMFZ DMTZVY3 MN Fatty acid-binding protein 4 (FABP4) DMTZVY3 MT DTT DMTZVY3 MA Inhibitor DMTZVY3 RN Fatty acid binding protein (FABP) inhibitors: a patent review (2012-2015).Expert Opin Ther Pat. 2016 Jul;26(7):767-76. DMTZVY3 RU https://www.ncbi.nlm.nih.gov/pubmed/27109571 DMTZVY3 DI DMTZVY3 DMTZVY3 DN PMID27109571-Compound-28 DMTZVY3 MI TTNT2S6 DMTZVY3 MN Fatty acid-binding protein 5 (FABP5) DMTZVY3 MT DTT DMTZVY3 MA Inhibitor DMTZVY3 RN Fatty acid binding protein (FABP) inhibitors: a patent review (2012-2015).Expert Opin Ther Pat. 2016 Jul;26(7):767-76. DMTZVY3 RU https://www.ncbi.nlm.nih.gov/pubmed/27109571 DMDMEHQ DI DMDMEHQ DMDMEHQ DN PMID27109571-Compound-29 DMDMEHQ MI TTHWMFZ DMDMEHQ MN Fatty acid-binding protein 4 (FABP4) DMDMEHQ MT DTT DMDMEHQ MA Inhibitor DMDMEHQ RN Fatty acid binding protein (FABP) inhibitors: a patent review (2012-2015).Expert Opin Ther Pat. 2016 Jul;26(7):767-76. DMDMEHQ RU https://www.ncbi.nlm.nih.gov/pubmed/27109571 DMDMEHQ DI DMDMEHQ DMDMEHQ DN PMID27109571-Compound-29 DMDMEHQ MI TTNT2S6 DMDMEHQ MN Fatty acid-binding protein 5 (FABP5) DMDMEHQ MT DTT DMDMEHQ MA Inhibitor DMDMEHQ RN Fatty acid binding protein (FABP) inhibitors: a patent review (2012-2015).Expert Opin Ther Pat. 2016 Jul;26(7):767-76. DMDMEHQ RU https://www.ncbi.nlm.nih.gov/pubmed/27109571 DMDXMH9 DI DMDXMH9 DMDXMH9 DN PMID27109571-Compound-3 DMDXMH9 MI TTMY6L1 DMDXMH9 MN Fatty acid-binding protein (FABP) DMDXMH9 MT DTT DMDXMH9 MA Inhibitor DMDXMH9 RN Fatty acid binding protein (FABP) inhibitors: a patent review (2012-2015).Expert Opin Ther Pat. 2016 Jul;26(7):767-76. DMDXMH9 RU https://www.ncbi.nlm.nih.gov/pubmed/27109571 DM24FSP DI DM24FSP DM24FSP DN PMID27109571-Compound-30 DM24FSP MI TTHWMFZ DM24FSP MN Fatty acid-binding protein 4 (FABP4) DM24FSP MT DTT DM24FSP MA Inhibitor DM24FSP RN Fatty acid binding protein (FABP) inhibitors: a patent review (2012-2015).Expert Opin Ther Pat. 2016 Jul;26(7):767-76. DM24FSP RU https://www.ncbi.nlm.nih.gov/pubmed/27109571 DM24FSP DI DM24FSP DM24FSP DN PMID27109571-Compound-30 DM24FSP MI TTNT2S6 DM24FSP MN Fatty acid-binding protein 5 (FABP5) DM24FSP MT DTT DM24FSP MA Inhibitor DM24FSP RN Fatty acid binding protein (FABP) inhibitors: a patent review (2012-2015).Expert Opin Ther Pat. 2016 Jul;26(7):767-76. DM24FSP RU https://www.ncbi.nlm.nih.gov/pubmed/27109571 DMU690T DI DMU690T DMU690T DN PMID27109571-Compound-31 DMU690T MI TTHWMFZ DMU690T MN Fatty acid-binding protein 4 (FABP4) DMU690T MT DTT DMU690T MA Inhibitor DMU690T RN Fatty acid binding protein (FABP) inhibitors: a patent review (2012-2015).Expert Opin Ther Pat. 2016 Jul;26(7):767-76. DMU690T RU https://www.ncbi.nlm.nih.gov/pubmed/27109571 DMU690T DI DMU690T DMU690T DN PMID27109571-Compound-31 DMU690T MI TTNT2S6 DMU690T MN Fatty acid-binding protein 5 (FABP5) DMU690T MT DTT DMU690T MA Inhibitor DMU690T RN Fatty acid binding protein (FABP) inhibitors: a patent review (2012-2015).Expert Opin Ther Pat. 2016 Jul;26(7):767-76. DMU690T RU https://www.ncbi.nlm.nih.gov/pubmed/27109571 DM4IS6Q DI DM4IS6Q DM4IS6Q DN PMID27109571-Compound-32 DM4IS6Q MI TTMY6L1 DM4IS6Q MN Fatty acid-binding protein (FABP) DM4IS6Q MT DTT DM4IS6Q MA Inhibitor DM4IS6Q RN Fatty acid binding protein (FABP) inhibitors: a patent review (2012-2015).Expert Opin Ther Pat. 2016 Jul;26(7):767-76. DM4IS6Q RU https://www.ncbi.nlm.nih.gov/pubmed/27109571 DMGR2JC DI DMGR2JC DMGR2JC DN PMID27109571-Compound-33 DMGR2JC MI TTMY6L1 DMGR2JC MN Fatty acid-binding protein (FABP) DMGR2JC MT DTT DMGR2JC MA Inhibitor DMGR2JC RN Fatty acid binding protein (FABP) inhibitors: a patent review (2012-2015).Expert Opin Ther Pat. 2016 Jul;26(7):767-76. DMGR2JC RU https://www.ncbi.nlm.nih.gov/pubmed/27109571 DM5OXUK DI DM5OXUK DM5OXUK DN PMID27109571-Compound-34 DM5OXUK MI TTMY6L1 DM5OXUK MN Fatty acid-binding protein (FABP) DM5OXUK MT DTT DM5OXUK MA Inhibitor DM5OXUK RN Fatty acid binding protein (FABP) inhibitors: a patent review (2012-2015).Expert Opin Ther Pat. 2016 Jul;26(7):767-76. DM5OXUK RU https://www.ncbi.nlm.nih.gov/pubmed/27109571 DMGV4PT DI DMGV4PT DMGV4PT DN PMID27109571-Compound-35 DMGV4PT MI TTMY6L1 DMGV4PT MN Fatty acid-binding protein (FABP) DMGV4PT MT DTT DMGV4PT MA Inhibitor DMGV4PT RN Fatty acid binding protein (FABP) inhibitors: a patent review (2012-2015).Expert Opin Ther Pat. 2016 Jul;26(7):767-76. DMGV4PT RU https://www.ncbi.nlm.nih.gov/pubmed/27109571 DMCJ48G DI DMCJ48G DMCJ48G DN PMID27109571-Compound-36 DMCJ48G MI TTMY6L1 DMCJ48G MN Fatty acid-binding protein (FABP) DMCJ48G MT DTT DMCJ48G MA Inhibitor DMCJ48G RN Fatty acid binding protein (FABP) inhibitors: a patent review (2012-2015).Expert Opin Ther Pat. 2016 Jul;26(7):767-76. DMCJ48G RU https://www.ncbi.nlm.nih.gov/pubmed/27109571 DMJCAOD DI DMJCAOD DMJCAOD DN PMID27109571-Compound-37 DMJCAOD MI TTMY6L1 DMJCAOD MN Fatty acid-binding protein (FABP) DMJCAOD MT DTT DMJCAOD MA Inhibitor DMJCAOD RN Fatty acid binding protein (FABP) inhibitors: a patent review (2012-2015).Expert Opin Ther Pat. 2016 Jul;26(7):767-76. DMJCAOD RU https://www.ncbi.nlm.nih.gov/pubmed/27109571 DMRQHDF DI DMRQHDF DMRQHDF DN PMID27109571-Compound-38 DMRQHDF MI TTMY6L1 DMRQHDF MN Fatty acid-binding protein (FABP) DMRQHDF MT DTT DMRQHDF MA Inhibitor DMRQHDF RN Fatty acid binding protein (FABP) inhibitors: a patent review (2012-2015).Expert Opin Ther Pat. 2016 Jul;26(7):767-76. DMRQHDF RU https://www.ncbi.nlm.nih.gov/pubmed/27109571 DMBHJDR DI DMBHJDR DMBHJDR DN PMID27109571-Compound-39 DMBHJDR MI TTMY6L1 DMBHJDR MN Fatty acid-binding protein (FABP) DMBHJDR MT DTT DMBHJDR MA Inhibitor DMBHJDR RN Fatty acid binding protein (FABP) inhibitors: a patent review (2012-2015).Expert Opin Ther Pat. 2016 Jul;26(7):767-76. DMBHJDR RU https://www.ncbi.nlm.nih.gov/pubmed/27109571 DMYRG0Q DI DMYRG0Q DMYRG0Q DN PMID27109571-Compound-4 DMYRG0Q MI TTMY6L1 DMYRG0Q MN Fatty acid-binding protein (FABP) DMYRG0Q MT DTT DMYRG0Q MA Inhibitor DMYRG0Q RN Fatty acid binding protein (FABP) inhibitors: a patent review (2012-2015).Expert Opin Ther Pat. 2016 Jul;26(7):767-76. DMYRG0Q RU https://www.ncbi.nlm.nih.gov/pubmed/27109571 DMQ83EV DI DMQ83EV DMQ83EV DN PMID27109571-Compound-40 DMQ83EV MI TTMY6L1 DMQ83EV MN Fatty acid-binding protein (FABP) DMQ83EV MT DTT DMQ83EV MA Inhibitor DMQ83EV RN Fatty acid binding protein (FABP) inhibitors: a patent review (2012-2015).Expert Opin Ther Pat. 2016 Jul;26(7):767-76. DMQ83EV RU https://www.ncbi.nlm.nih.gov/pubmed/27109571 DMY4IAV DI DMY4IAV DMY4IAV DN PMID27109571-Compound-41 DMY4IAV MI TTMY6L1 DMY4IAV MN Fatty acid-binding protein (FABP) DMY4IAV MT DTT DMY4IAV MA Inhibitor DMY4IAV RN Fatty acid binding protein (FABP) inhibitors: a patent review (2012-2015).Expert Opin Ther Pat. 2016 Jul;26(7):767-76. DMY4IAV RU https://www.ncbi.nlm.nih.gov/pubmed/27109571 DMZOI3K DI DMZOI3K DMZOI3K DN PMID27109571-Compound-42 DMZOI3K MI TTMY6L1 DMZOI3K MN Fatty acid-binding protein (FABP) DMZOI3K MT DTT DMZOI3K MA Inhibitor DMZOI3K RN Fatty acid binding protein (FABP) inhibitors: a patent review (2012-2015).Expert Opin Ther Pat. 2016 Jul;26(7):767-76. DMZOI3K RU https://www.ncbi.nlm.nih.gov/pubmed/27109571 DMYZ42W DI DMYZ42W DMYZ42W DN PMID27109571-Compound-43 DMYZ42W MI TTMY6L1 DMYZ42W MN Fatty acid-binding protein (FABP) DMYZ42W MT DTT DMYZ42W MA Inhibitor DMYZ42W RN Fatty acid binding protein (FABP) inhibitors: a patent review (2012-2015).Expert Opin Ther Pat. 2016 Jul;26(7):767-76. DMYZ42W RU https://www.ncbi.nlm.nih.gov/pubmed/27109571 DM3AUZS DI DM3AUZS DM3AUZS DN PMID27109571-Compound-44 DM3AUZS MI TTMY6L1 DM3AUZS MN Fatty acid-binding protein (FABP) DM3AUZS MT DTT DM3AUZS MA Inhibitor DM3AUZS RN Fatty acid binding protein (FABP) inhibitors: a patent review (2012-2015).Expert Opin Ther Pat. 2016 Jul;26(7):767-76. DM3AUZS RU https://www.ncbi.nlm.nih.gov/pubmed/27109571 DMOZKAH DI DMOZKAH DMOZKAH DN PMID27109571-Compound-5 DMOZKAH MI TTMY6L1 DMOZKAH MN Fatty acid-binding protein (FABP) DMOZKAH MT DTT DMOZKAH MA Inhibitor DMOZKAH RN Fatty acid binding protein (FABP) inhibitors: a patent review (2012-2015).Expert Opin Ther Pat. 2016 Jul;26(7):767-76. DMOZKAH RU https://www.ncbi.nlm.nih.gov/pubmed/27109571 DMPHMTR DI DMPHMTR DMPHMTR DN PMID27109571-Compound-6 DMPHMTR MI TTMY6L1 DMPHMTR MN Fatty acid-binding protein (FABP) DMPHMTR MT DTT DMPHMTR MA Inhibitor DMPHMTR RN Fatty acid binding protein (FABP) inhibitors: a patent review (2012-2015).Expert Opin Ther Pat. 2016 Jul;26(7):767-76. DMPHMTR RU https://www.ncbi.nlm.nih.gov/pubmed/27109571 DM8GYCD DI DM8GYCD DM8GYCD DN PMID27109571-Compound-7 DM8GYCD MI TTHWMFZ DM8GYCD MN Fatty acid-binding protein 4 (FABP4) DM8GYCD MT DTT DM8GYCD MA Inhibitor DM8GYCD RN Fatty acid binding protein (FABP) inhibitors: a patent review (2012-2015).Expert Opin Ther Pat. 2016 Jul;26(7):767-76. DM8GYCD RU https://www.ncbi.nlm.nih.gov/pubmed/27109571 DMTKFX7 DI DMTKFX7 DMTKFX7 DN PMID27109571-Compound-8 DMTKFX7 MI TTHWMFZ DMTKFX7 MN Fatty acid-binding protein 4 (FABP4) DMTKFX7 MT DTT DMTKFX7 MA Inhibitor DMTKFX7 RN Fatty acid binding protein (FABP) inhibitors: a patent review (2012-2015).Expert Opin Ther Pat. 2016 Jul;26(7):767-76. DMTKFX7 RU https://www.ncbi.nlm.nih.gov/pubmed/27109571 DMWM03O DI DMWM03O DMWM03O DN PMID27109571-Compound-9 DMWM03O MI TTHWMFZ DMWM03O MN Fatty acid-binding protein 4 (FABP4) DMWM03O MT DTT DMWM03O MA Inhibitor DMWM03O RN Fatty acid binding protein (FABP) inhibitors: a patent review (2012-2015).Expert Opin Ther Pat. 2016 Jul;26(7):767-76. DMWM03O RU https://www.ncbi.nlm.nih.gov/pubmed/27109571 DMBWLSA DI DMBWLSA DMBWLSA DN PMID27172114-Compound-30 DMBWLSA MI TTZJYKH DMBWLSA MN Indoleamine 2,3-dioxygenase 1 (IDO1) DMBWLSA MT DTT DMBWLSA MA Inhibitor DMBWLSA RN Inhibitors of the kynurenine pathway as neurotherapeutics: a patent review (2012-2015).Expert Opin Ther Pat. 2016 Jul;26(7):815-32. DMBWLSA RU https://www.ncbi.nlm.nih.gov/pubmed/27172114 DMBWLSA DI DMBWLSA DMBWLSA DN PMID27172114-Compound-30 DMBWLSA MI TTALN9W DMBWLSA MN Indoleamine 2,3-dioxygenase 2 (IDO2) DMBWLSA MT DTT DMBWLSA MA Inhibitor DMBWLSA RN Inhibitors of the kynurenine pathway as neurotherapeutics: a patent review (2012-2015).Expert Opin Ther Pat. 2016 Jul;26(7):815-32. DMBWLSA RU https://www.ncbi.nlm.nih.gov/pubmed/27172114 DMBWLSA DI DMBWLSA DMBWLSA DN PMID27172114-Compound-30 DMBWLSA MI TTXNCBV DMBWLSA MN Tryptophan 2,3-dioxygenase (TDO) DMBWLSA MT DTT DMBWLSA MA Inhibitor DMBWLSA RN Inhibitors of the kynurenine pathway as neurotherapeutics: a patent review (2012-2015).Expert Opin Ther Pat. 2016 Jul;26(7):815-32. DMBWLSA RU https://www.ncbi.nlm.nih.gov/pubmed/27172114 DMTIQYD DI DMTIQYD DMTIQYD DN PMID27172114-Compound-47 DMTIQYD MI TTIY56R DMTIQYD MN Kynurenine 3-hydroxylase (KMO) DMTIQYD MT DTT DMTIQYD MA Inhibitor DMTIQYD RN Inhibitors of the kynurenine pathway as neurotherapeutics: a patent review (2012-2015).Expert Opin Ther Pat. 2016 Jul;26(7):815-32. DMTIQYD RU https://www.ncbi.nlm.nih.gov/pubmed/27172114 DMSXJVY DI DMSXJVY DMSXJVY DN PMID27172114-Compound-49 DMSXJVY MI TTIY56R DMSXJVY MN Kynurenine 3-hydroxylase (KMO) DMSXJVY MT DTT DMSXJVY MA Inhibitor DMSXJVY RN Inhibitors of the kynurenine pathway as neurotherapeutics: a patent review (2012-2015).Expert Opin Ther Pat. 2016 Jul;26(7):815-32. DMSXJVY RU https://www.ncbi.nlm.nih.gov/pubmed/27172114 DM84RES DI DM84RES DM84RES DN PMID27215781-Compound-1 DM84RES MI TT6OEDT DM84RES MN Cannabinoid receptor 1 (CB1) DM84RES MT DTT DM84RES MA Agonist DM84RES RN Cannabinoid receptor 2 (CB2) agonists and antagonists: a patent update.Expert Opin Ther Pat. 2016 Jul;26(7):843-56. DM84RES RU https://www.ncbi.nlm.nih.gov/pubmed/27215781 DMIX90M DI DMIX90M DMIX90M DN PMID27215781-Compound-11 DMIX90M MI TTMSFAW DMIX90M MN Cannabinoid receptor 2 (CB2) DMIX90M MT DTT DMIX90M RN Cannabinoid receptor 2 (CB2) agonists and antagonists: a patent update.Expert Opin Ther Pat. 2016 Jul;26(7):843-56. DMIX90M RU https://www.ncbi.nlm.nih.gov/pubmed/27215781 DMR9GLW DI DMR9GLW DMR9GLW DN PMID27215781-Compound-12 DMR9GLW MI TTMSFAW DMR9GLW MN Cannabinoid receptor 2 (CB2) DMR9GLW MT DTT DMR9GLW RN Cannabinoid receptor 2 (CB2) agonists and antagonists: a patent update.Expert Opin Ther Pat. 2016 Jul;26(7):843-56. DMR9GLW RU https://www.ncbi.nlm.nih.gov/pubmed/27215781 DMNKH07 DI DMNKH07 DMNKH07 DN PMID27215781-Compound-13 DMNKH07 MI TTMSFAW DMNKH07 MN Cannabinoid receptor 2 (CB2) DMNKH07 MT DTT DMNKH07 RN Cannabinoid receptor 2 (CB2) agonists and antagonists: a patent update.Expert Opin Ther Pat. 2016 Jul;26(7):843-56. DMNKH07 RU https://www.ncbi.nlm.nih.gov/pubmed/27215781 DMYMTSL DI DMYMTSL DMYMTSL DN PMID27215781-Compound-19 DMYMTSL MI TTMSFAW DMYMTSL MN Cannabinoid receptor 2 (CB2) DMYMTSL MT DTT DMYMTSL MA Agonist DMYMTSL RN Cannabinoid receptor 2 (CB2) agonists and antagonists: a patent update.Expert Opin Ther Pat. 2016 Jul;26(7):843-56. DMYMTSL RU https://www.ncbi.nlm.nih.gov/pubmed/27215781 DMBOX0K DI DMBOX0K DMBOX0K DN PMID27215781-Compound-2 DMBOX0K MI TT6OEDT DMBOX0K MN Cannabinoid receptor 1 (CB1) DMBOX0K MT DTT DMBOX0K MA Agonist DMBOX0K RN Cannabinoid receptor 2 (CB2) agonists and antagonists: a patent update.Expert Opin Ther Pat. 2016 Jul;26(7):843-56. DMBOX0K RU https://www.ncbi.nlm.nih.gov/pubmed/27215781 DMBOX0K DI DMBOX0K DMBOX0K DN PMID27215781-Compound-2 DMBOX0K MI TTMSFAW DMBOX0K MN Cannabinoid receptor 2 (CB2) DMBOX0K MT DTT DMBOX0K MA Agonist DMBOX0K RN Cannabinoid receptor 2 (CB2) agonists and antagonists: a patent update.Expert Opin Ther Pat. 2016 Jul;26(7):843-56. DMBOX0K RU https://www.ncbi.nlm.nih.gov/pubmed/27215781 DMKZF8E DI DMKZF8E DMKZF8E DN PMID27215781-Compound-25 DMKZF8E MI TTMSFAW DMKZF8E MN Cannabinoid receptor 2 (CB2) DMKZF8E MT DTT DMKZF8E MA Agonist DMKZF8E RN Cannabinoid receptor 2 (CB2) agonists and antagonists: a patent update.Expert Opin Ther Pat. 2016 Jul;26(7):843-56. DMKZF8E RU https://www.ncbi.nlm.nih.gov/pubmed/27215781 DMTJHC2 DI DMTJHC2 DMTJHC2 DN PMID27215781-Compound-27 DMTJHC2 MI TTMSFAW DMTJHC2 MN Cannabinoid receptor 2 (CB2) DMTJHC2 MT DTT DMTJHC2 MA Agonist DMTJHC2 RN Cannabinoid receptor 2 (CB2) agonists and antagonists: a patent update.Expert Opin Ther Pat. 2016 Jul;26(7):843-56. DMTJHC2 RU https://www.ncbi.nlm.nih.gov/pubmed/27215781 DM9ZF3P DI DM9ZF3P DM9ZF3P DN PMID27215781-Compound-28 DM9ZF3P MI TTMSFAW DM9ZF3P MN Cannabinoid receptor 2 (CB2) DM9ZF3P MT DTT DM9ZF3P MA Agonist DM9ZF3P RN Cannabinoid receptor 2 (CB2) agonists and antagonists: a patent update.Expert Opin Ther Pat. 2016 Jul;26(7):843-56. DM9ZF3P RU https://www.ncbi.nlm.nih.gov/pubmed/27215781 DMDJM1Y DI DMDJM1Y DMDJM1Y DN PMID27215781-Compound-29 DMDJM1Y MI TTMSFAW DMDJM1Y MN Cannabinoid receptor 2 (CB2) DMDJM1Y MT DTT DMDJM1Y MA Agonist DMDJM1Y RN Cannabinoid receptor 2 (CB2) agonists and antagonists: a patent update.Expert Opin Ther Pat. 2016 Jul;26(7):843-56. DMDJM1Y RU https://www.ncbi.nlm.nih.gov/pubmed/27215781 DM7USO9 DI DM7USO9 DM7USO9 DN PMID27215781-Compound-30 DM7USO9 MI TTMSFAW DM7USO9 MN Cannabinoid receptor 2 (CB2) DM7USO9 MT DTT DM7USO9 MA Agonist DM7USO9 RN Cannabinoid receptor 2 (CB2) agonists and antagonists: a patent update.Expert Opin Ther Pat. 2016 Jul;26(7):843-56. DM7USO9 RU https://www.ncbi.nlm.nih.gov/pubmed/27215781 DMJMO72 DI DMJMO72 DMJMO72 DN PMID27215781-Compound-31 DMJMO72 MI TTMSFAW DMJMO72 MN Cannabinoid receptor 2 (CB2) DMJMO72 MT DTT DMJMO72 MA Agonist DMJMO72 RN Cannabinoid receptor 2 (CB2) agonists and antagonists: a patent update.Expert Opin Ther Pat. 2016 Jul;26(7):843-56. DMJMO72 RU https://www.ncbi.nlm.nih.gov/pubmed/27215781 DM7IYRM DI DM7IYRM DM7IYRM DN PMID27215781-Compound-32 DM7IYRM MI TTMSFAW DM7IYRM MN Cannabinoid receptor 2 (CB2) DM7IYRM MT DTT DM7IYRM RN Cannabinoid receptor 2 (CB2) agonists and antagonists: a patent update.Expert Opin Ther Pat. 2016 Jul;26(7):843-56. DM7IYRM RU https://www.ncbi.nlm.nih.gov/pubmed/27215781 DMX4W2R DI DMX4W2R DMX4W2R DN PMID27215781-Compound-33 DMX4W2R MI TTMSFAW DMX4W2R MN Cannabinoid receptor 2 (CB2) DMX4W2R MT DTT DMX4W2R RN Cannabinoid receptor 2 (CB2) agonists and antagonists: a patent update.Expert Opin Ther Pat. 2016 Jul;26(7):843-56. DMX4W2R RU https://www.ncbi.nlm.nih.gov/pubmed/27215781 DMTAZBC DI DMTAZBC DMTAZBC DN PMID27215781-Compound-34 DMTAZBC MI TTMSFAW DMTAZBC MN Cannabinoid receptor 2 (CB2) DMTAZBC MT DTT DMTAZBC RN Cannabinoid receptor 2 (CB2) agonists and antagonists: a patent update.Expert Opin Ther Pat. 2016 Jul;26(7):843-56. DMTAZBC RU https://www.ncbi.nlm.nih.gov/pubmed/27215781 DM0L68P DI DM0L68P DM0L68P DN PMID27215781-Compound-37 DM0L68P MI TT6OEDT DM0L68P MN Cannabinoid receptor 1 (CB1) DM0L68P MT DTT DM0L68P RN Cannabinoid receptor 2 (CB2) agonists and antagonists: a patent update.Expert Opin Ther Pat. 2016 Jul;26(7):843-56. DM0L68P RU https://www.ncbi.nlm.nih.gov/pubmed/27215781 DM0L68P DI DM0L68P DM0L68P DN PMID27215781-Compound-37 DM0L68P MI TTMSFAW DM0L68P MN Cannabinoid receptor 2 (CB2) DM0L68P MT DTT DM0L68P RN Cannabinoid receptor 2 (CB2) agonists and antagonists: a patent update.Expert Opin Ther Pat. 2016 Jul;26(7):843-56. DM0L68P RU https://www.ncbi.nlm.nih.gov/pubmed/27215781 DMRU0BL DI DMRU0BL DMRU0BL DN PMID27215781-Compound-4 DMRU0BL MI TTMSFAW DMRU0BL MN Cannabinoid receptor 2 (CB2) DMRU0BL MT DTT DMRU0BL MA Agonist DMRU0BL RN Cannabinoid receptor 2 (CB2) agonists and antagonists: a patent update.Expert Opin Ther Pat. 2016 Jul;26(7):843-56. DMRU0BL RU https://www.ncbi.nlm.nih.gov/pubmed/27215781 DM0NYK3 DI DM0NYK3 DM0NYK3 DN PMID27321640-Compound-58 DM0NYK3 MI TTJW4LU DM0NYK3 MN Phosphodiesterase 10A (PDE10) DM0NYK3 MT DTT DM0NYK3 MA Inhibitor DM0NYK3 RN Towards selective phosphodiesterase 2A (PDE2A) inhibitors: a patent review (2010 - present).Expert Opin Ther Pat. 2016 Aug;26(8):933-46. DM0NYK3 RU https://www.ncbi.nlm.nih.gov/pubmed/27321640 DM0NYK3 DI DM0NYK3 DM0NYK3 DN PMID27321640-Compound-58 DM0NYK3 MI TTJGW1Z DM0NYK3 MN Phosphodiesterase 2A (PDE2A) DM0NYK3 MT DTT DM0NYK3 MA Inhibitor DM0NYK3 RN Towards selective phosphodiesterase 2A (PDE2A) inhibitors: a patent review (2010 - present).Expert Opin Ther Pat. 2016 Aug;26(8):933-46. DM0NYK3 RU https://www.ncbi.nlm.nih.gov/pubmed/27321640 DM41B5O DI DM41B5O DM41B5O DN PMID27321640-Compound-59 DM41B5O MI TTJW4LU DM41B5O MN Phosphodiesterase 10A (PDE10) DM41B5O MT DTT DM41B5O MA Inhibitor DM41B5O RN Towards selective phosphodiesterase 2A (PDE2A) inhibitors: a patent review (2010 - present).Expert Opin Ther Pat. 2016 Aug;26(8):933-46. DM41B5O RU https://www.ncbi.nlm.nih.gov/pubmed/27321640 DM41B5O DI DM41B5O DM41B5O DN PMID27321640-Compound-59 DM41B5O MI TTJGW1Z DM41B5O MN Phosphodiesterase 2A (PDE2A) DM41B5O MT DTT DM41B5O MA Inhibitor DM41B5O RN Towards selective phosphodiesterase 2A (PDE2A) inhibitors: a patent review (2010 - present).Expert Opin Ther Pat. 2016 Aug;26(8):933-46. DM41B5O RU https://www.ncbi.nlm.nih.gov/pubmed/27321640 DMHWV67 DI DMHWV67 DMHWV67 DN PMID27321640-Compound-74 DMHWV67 MI TTJGW1Z DMHWV67 MN Phosphodiesterase 2A (PDE2A) DMHWV67 MT DTT DMHWV67 MA Inhibitor DMHWV67 RN Towards selective phosphodiesterase 2A (PDE2A) inhibitors: a patent review (2010 - present).Expert Opin Ther Pat. 2016 Aug;26(8):933-46. DMHWV67 RU https://www.ncbi.nlm.nih.gov/pubmed/27321640 DM2P5J9 DI DM2P5J9 DM2P5J9 DN PMID27321640-Compound-75 DM2P5J9 MI TTJGW1Z DM2P5J9 MN Phosphodiesterase 2A (PDE2A) DM2P5J9 MT DTT DM2P5J9 MA Inhibitor DM2P5J9 RN Towards selective phosphodiesterase 2A (PDE2A) inhibitors: a patent review (2010 - present).Expert Opin Ther Pat. 2016 Aug;26(8):933-46. DM2P5J9 RU https://www.ncbi.nlm.nih.gov/pubmed/27321640 DM40LIN DI DM40LIN DM40LIN DN PMID27321640-Compound-76 DM40LIN MI TTJGW1Z DM40LIN MN Phosphodiesterase 2A (PDE2A) DM40LIN MT DTT DM40LIN MA Inhibitor DM40LIN RN Towards selective phosphodiesterase 2A (PDE2A) inhibitors: a patent review (2010 - present).Expert Opin Ther Pat. 2016 Aug;26(8):933-46. DM40LIN RU https://www.ncbi.nlm.nih.gov/pubmed/27321640 DMYUP6G DI DMYUP6G DMYUP6G DN PMID27336223-Compound-10 DMYUP6G MI TTISP28 DMYUP6G MN Retinoic acid receptor beta (RARB) DMYUP6G MT DTT DMYUP6G MA Agonist DMYUP6G RN Therapeutic use of selective synthetic ligands for retinoic acid receptors: a patent review.Expert Opin Ther Pat. 2016 Aug;26(8):957-71. DMYUP6G RU https://www.ncbi.nlm.nih.gov/pubmed/27336223 DMBN6KU DI DMBN6KU DMBN6KU DN PMID27336223-Compound-11 DMBN6KU MI TT1Q3IE DMBN6KU MN Retinoic acid receptor gamma (RARG) DMBN6KU MT DTT DMBN6KU MA Agonist DMBN6KU RN Therapeutic use of selective synthetic ligands for retinoic acid receptors: a patent review.Expert Opin Ther Pat. 2016 Aug;26(8):957-71. DMBN6KU RU https://www.ncbi.nlm.nih.gov/pubmed/27336223 DMT4P7K DI DMT4P7K DMT4P7K DN PMID27336223-Compound-12 DMT4P7K MI TT1Q3IE DMT4P7K MN Retinoic acid receptor gamma (RARG) DMT4P7K MT DTT DMT4P7K MA Agonist DMT4P7K RN Therapeutic use of selective synthetic ligands for retinoic acid receptors: a patent review.Expert Opin Ther Pat. 2016 Aug;26(8):957-71. DMT4P7K RU https://www.ncbi.nlm.nih.gov/pubmed/27336223 DMSZLYD DI DMSZLYD DMSZLYD DN PMID27336223-Compound-13 DMSZLYD MI TT1Q3IE DMSZLYD MN Retinoic acid receptor gamma (RARG) DMSZLYD MT DTT DMSZLYD MA Agonist DMSZLYD RN Therapeutic use of selective synthetic ligands for retinoic acid receptors: a patent review.Expert Opin Ther Pat. 2016 Aug;26(8):957-71. DMSZLYD RU https://www.ncbi.nlm.nih.gov/pubmed/27336223 DMC41MA DI DMC41MA DMC41MA DN PMID27336223-Compound-14 DMC41MA MI TT1Q3IE DMC41MA MN Retinoic acid receptor gamma (RARG) DMC41MA MT DTT DMC41MA MA Agonist DMC41MA RN Therapeutic use of selective synthetic ligands for retinoic acid receptors: a patent review.Expert Opin Ther Pat. 2016 Aug;26(8):957-71. DMC41MA RU https://www.ncbi.nlm.nih.gov/pubmed/27336223 DMIYCFE DI DMIYCFE DMIYCFE DN PMID27336223-Compound-15 DMIYCFE MI TT1Q3IE DMIYCFE MN Retinoic acid receptor gamma (RARG) DMIYCFE MT DTT DMIYCFE MA Agonist DMIYCFE RN Therapeutic use of selective synthetic ligands for retinoic acid receptors: a patent review.Expert Opin Ther Pat. 2016 Aug;26(8):957-71. DMIYCFE RU https://www.ncbi.nlm.nih.gov/pubmed/27336223 DMJFSOM DI DMJFSOM DMJFSOM DN PMID27336223-Compound-4 DMJFSOM MI TTW38KT DMJFSOM MN Retinoic acid receptor alpha (RARA) DMJFSOM MT DTT DMJFSOM MA Agonist DMJFSOM RN Therapeutic use of selective synthetic ligands for retinoic acid receptors: a patent review.Expert Opin Ther Pat. 2016 Aug;26(8):957-71. DMJFSOM RU https://www.ncbi.nlm.nih.gov/pubmed/27336223 DM6E50A DI DM6E50A DM6E50A DN PMID27336223-Compound-5 DM6E50A MI TTW38KT DM6E50A MN Retinoic acid receptor alpha (RARA) DM6E50A MT DTT DM6E50A MA Agonist DM6E50A RN Therapeutic use of selective synthetic ligands for retinoic acid receptors: a patent review.Expert Opin Ther Pat. 2016 Aug;26(8):957-71. DM6E50A RU https://www.ncbi.nlm.nih.gov/pubmed/27336223 DM9QM6I DI DM9QM6I DM9QM6I DN PMID27336223-Compound-7 DM9QM6I MI TTISP28 DM9QM6I MN Retinoic acid receptor beta (RARB) DM9QM6I MT DTT DM9QM6I MA Agonist DM9QM6I RN Therapeutic use of selective synthetic ligands for retinoic acid receptors: a patent review.Expert Opin Ther Pat. 2016 Aug;26(8):957-71. DM9QM6I RU https://www.ncbi.nlm.nih.gov/pubmed/27336223 DM460D1 DI DM460D1 DM460D1 DN PMID27336223-Compound-8 DM460D1 MI TTISP28 DM460D1 MN Retinoic acid receptor beta (RARB) DM460D1 MT DTT DM460D1 MA Agonist DM460D1 RN Therapeutic use of selective synthetic ligands for retinoic acid receptors: a patent review.Expert Opin Ther Pat. 2016 Aug;26(8):957-71. DM460D1 RU https://www.ncbi.nlm.nih.gov/pubmed/27336223 DM6V13W DI DM6V13W DM6V13W DN PMID27336223-Compound-9 DM6V13W MI TT1Q3IE DM6V13W MN Retinoic acid receptor gamma (RARG) DM6V13W MT DTT DM6V13W MA Agonist DM6V13W RN Therapeutic use of selective synthetic ligands for retinoic acid receptors: a patent review.Expert Opin Ther Pat. 2016 Aug;26(8):957-71. DM6V13W RU https://www.ncbi.nlm.nih.gov/pubmed/27336223 DMTQRVC DI DMTQRVC DMTQRVC DN PMID27376512-Compound-asCEBP-1 DMTQRVC MI TT6S2FE DMTQRVC MN DNA [cytosine-5]-methyltransferase 1 (DNMT1) DMTQRVC MT DTT DMTQRVC MA Inhibitor DMTQRVC RN DNA methyltransferase inhibitors: an updated patent review (2012-2015).Expert Opin Ther Pat. 2016 Sep;26(9):1017-30. DMTQRVC RU https://www.ncbi.nlm.nih.gov/pubmed/27376512 DMLAY8B DI DMLAY8B DMLAY8B DN PMID27376512-Compound-asCEBP-1HPE DMLAY8B MI TT6S2FE DMLAY8B MN DNA [cytosine-5]-methyltransferase 1 (DNMT1) DMLAY8B MT DTT DMLAY8B MA Inhibitor DMLAY8B RN DNA methyltransferase inhibitors: an updated patent review (2012-2015).Expert Opin Ther Pat. 2016 Sep;26(9):1017-30. DMLAY8B RU https://www.ncbi.nlm.nih.gov/pubmed/27376512 DMJUL1A DI DMJUL1A DMJUL1A DN PMID27376512-Compound-asCEBP-2 DMJUL1A MI TT6S2FE DMJUL1A MN DNA [cytosine-5]-methyltransferase 1 (DNMT1) DMJUL1A MT DTT DMJUL1A MA Inhibitor DMJUL1A RN DNA methyltransferase inhibitors: an updated patent review (2012-2015).Expert Opin Ther Pat. 2016 Sep;26(9):1017-30. DMJUL1A RU https://www.ncbi.nlm.nih.gov/pubmed/27376512 DM9QEIV DI DM9QEIV DM9QEIV DN PMID27376512-Compound-asCEBP-2HPE DM9QEIV MI TT6S2FE DM9QEIV MN DNA [cytosine-5]-methyltransferase 1 (DNMT1) DM9QEIV MT DTT DM9QEIV MA Inhibitor DM9QEIV RN DNA methyltransferase inhibitors: an updated patent review (2012-2015).Expert Opin Ther Pat. 2016 Sep;26(9):1017-30. DM9QEIV RU https://www.ncbi.nlm.nih.gov/pubmed/27376512 DMBFUTL DI DMBFUTL DMBFUTL DN PMID27376512-Compound-CROs DMBFUTL MI TTHVCUP DMBFUTL MN DNA [cytosine-5]-methyltransferase (DNMT) DMBFUTL MT DTT DMBFUTL MA Inhibitor DMBFUTL RN DNA methyltransferase inhibitors: an updated patent review (2012-2015).Expert Opin Ther Pat. 2016 Sep;26(9):1017-30. DMBFUTL RU https://www.ncbi.nlm.nih.gov/pubmed/27376512 DMP59OX DI DMP59OX DMP59OX DN PMID27376512-Compound-Figure2aExample1 DMP59OX MI TTJUALD DMP59OX MN DNA [cytosine-5]-methyltransferase 3A (DNMT3A) DMP59OX MT DTT DMP59OX MA Inhibitor DMP59OX RN DNA methyltransferase inhibitors: an updated patent review (2012-2015).Expert Opin Ther Pat. 2016 Sep;26(9):1017-30. DMP59OX RU https://www.ncbi.nlm.nih.gov/pubmed/27376512 DMP59OX DI DMP59OX DMP59OX DN PMID27376512-Compound-Figure2aExample1 DMP59OX MI TT3FDAV DMP59OX MN DNA [cytosine-5]-methyltransferase 3-like (DNMT3L) DMP59OX MT DTT DMP59OX MA Inhibitor DMP59OX RN DNA methyltransferase inhibitors: an updated patent review (2012-2015).Expert Opin Ther Pat. 2016 Sep;26(9):1017-30. DMP59OX RU https://www.ncbi.nlm.nih.gov/pubmed/27376512 DMZIKN6 DI DMZIKN6 DMZIKN6 DN PMID27376512-Compound-Figure3CG DMZIKN6 MI TTJUALD DMZIKN6 MN DNA [cytosine-5]-methyltransferase 3A (DNMT3A) DMZIKN6 MT DTT DMZIKN6 MA Inhibitor DMZIKN6 RN DNA methyltransferase inhibitors: an updated patent review (2012-2015).Expert Opin Ther Pat. 2016 Sep;26(9):1017-30. DMZIKN6 RU https://www.ncbi.nlm.nih.gov/pubmed/27376512 DMIS4H0 DI DMIS4H0 DMIS4H0 DN PMID27376512-Compound-Figure3CM DMIS4H0 MI TTJUALD DMIS4H0 MN DNA [cytosine-5]-methyltransferase 3A (DNMT3A) DMIS4H0 MT DTT DMIS4H0 MA Inhibitor DMIS4H0 RN DNA methyltransferase inhibitors: an updated patent review (2012-2015).Expert Opin Ther Pat. 2016 Sep;26(9):1017-30. DMIS4H0 RU https://www.ncbi.nlm.nih.gov/pubmed/27376512 DMP7DL6 DI DMP7DL6 DMP7DL6 DN PMID27376512-Compound-Figure3CN DMP7DL6 MI TTJUALD DMP7DL6 MN DNA [cytosine-5]-methyltransferase 3A (DNMT3A) DMP7DL6 MT DTT DMP7DL6 MA Inhibitor DMP7DL6 RN DNA methyltransferase inhibitors: an updated patent review (2012-2015).Expert Opin Ther Pat. 2016 Sep;26(9):1017-30. DMP7DL6 RU https://www.ncbi.nlm.nih.gov/pubmed/27376512 DM67VNW DI DM67VNW DM67VNW DN PMID27376512-Compound-miR-155-5p DM67VNW MI TT6S2FE DM67VNW MN DNA [cytosine-5]-methyltransferase 1 (DNMT1) DM67VNW MT DTT DM67VNW MA Inhibitor DM67VNW RN DNA methyltransferase inhibitors: an updated patent review (2012-2015).Expert Opin Ther Pat. 2016 Sep;26(9):1017-30. DM67VNW RU https://www.ncbi.nlm.nih.gov/pubmed/27376512 DM1MVQD DI DM1MVQD DM1MVQD DN PMID27376512-Compound-MTC-422 DM1MVQD MI TT6S2FE DM1MVQD MN DNA [cytosine-5]-methyltransferase 1 (DNMT1) DM1MVQD MT DTT DM1MVQD MA Inhibitor DM1MVQD RN DNA methyltransferase inhibitors: an updated patent review (2012-2015).Expert Opin Ther Pat. 2016 Sep;26(9):1017-30. DM1MVQD RU https://www.ncbi.nlm.nih.gov/pubmed/27376512 DM1MVQD DI DM1MVQD DM1MVQD DN PMID27376512-Compound-MTC-422 DM1MVQD MI TTJUALD DM1MVQD MN DNA [cytosine-5]-methyltransferase 3A (DNMT3A) DM1MVQD MT DTT DM1MVQD MA Inhibitor DM1MVQD RN DNA methyltransferase inhibitors: an updated patent review (2012-2015).Expert Opin Ther Pat. 2016 Sep;26(9):1017-30. DM1MVQD RU https://www.ncbi.nlm.nih.gov/pubmed/27376512 DM1MVQD DI DM1MVQD DM1MVQD DN PMID27376512-Compound-MTC-422 DM1MVQD MI TT6VZ78 DM1MVQD MN DNA [cytosine-5]-methyltransferase 3B (DNMT3B) DM1MVQD MT DTT DM1MVQD MA Inhibitor DM1MVQD RN DNA methyltransferase inhibitors: an updated patent review (2012-2015).Expert Opin Ther Pat. 2016 Sep;26(9):1017-30. DM1MVQD RU https://www.ncbi.nlm.nih.gov/pubmed/27376512 DM9RSDX DI DM9RSDX DM9RSDX DN PMID27376512-Compound-MTC-423 DM9RSDX MI TT6S2FE DM9RSDX MN DNA [cytosine-5]-methyltransferase 1 (DNMT1) DM9RSDX MT DTT DM9RSDX MA Inhibitor DM9RSDX RN DNA methyltransferase inhibitors: an updated patent review (2012-2015).Expert Opin Ther Pat. 2016 Sep;26(9):1017-30. DM9RSDX RU https://www.ncbi.nlm.nih.gov/pubmed/27376512 DM9RSDX DI DM9RSDX DM9RSDX DN PMID27376512-Compound-MTC-423 DM9RSDX MI TTJUALD DM9RSDX MN DNA [cytosine-5]-methyltransferase 3A (DNMT3A) DM9RSDX MT DTT DM9RSDX MA Inhibitor DM9RSDX RN DNA methyltransferase inhibitors: an updated patent review (2012-2015).Expert Opin Ther Pat. 2016 Sep;26(9):1017-30. DM9RSDX RU https://www.ncbi.nlm.nih.gov/pubmed/27376512 DM9RSDX DI DM9RSDX DM9RSDX DN PMID27376512-Compound-MTC-423 DM9RSDX MI TT6VZ78 DM9RSDX MN DNA [cytosine-5]-methyltransferase 3B (DNMT3B) DM9RSDX MT DTT DM9RSDX MA Inhibitor DM9RSDX RN DNA methyltransferase inhibitors: an updated patent review (2012-2015).Expert Opin Ther Pat. 2016 Sep;26(9):1017-30. DM9RSDX RU https://www.ncbi.nlm.nih.gov/pubmed/27376512 DMGNRZU DI DMGNRZU DMGNRZU DN PMID27376512-Compound-MTC-424 DMGNRZU MI TT6S2FE DMGNRZU MN DNA [cytosine-5]-methyltransferase 1 (DNMT1) DMGNRZU MT DTT DMGNRZU MA Inhibitor DMGNRZU RN DNA methyltransferase inhibitors: an updated patent review (2012-2015).Expert Opin Ther Pat. 2016 Sep;26(9):1017-30. DMGNRZU RU https://www.ncbi.nlm.nih.gov/pubmed/27376512 DMGNRZU DI DMGNRZU DMGNRZU DN PMID27376512-Compound-MTC-424 DMGNRZU MI TTJUALD DMGNRZU MN DNA [cytosine-5]-methyltransferase 3A (DNMT3A) DMGNRZU MT DTT DMGNRZU MA Inhibitor DMGNRZU RN DNA methyltransferase inhibitors: an updated patent review (2012-2015).Expert Opin Ther Pat. 2016 Sep;26(9):1017-30. DMGNRZU RU https://www.ncbi.nlm.nih.gov/pubmed/27376512 DMGNRZU DI DMGNRZU DMGNRZU DN PMID27376512-Compound-MTC-424 DMGNRZU MI TT6VZ78 DMGNRZU MN DNA [cytosine-5]-methyltransferase 3B (DNMT3B) DMGNRZU MT DTT DMGNRZU MA Inhibitor DMGNRZU RN DNA methyltransferase inhibitors: an updated patent review (2012-2015).Expert Opin Ther Pat. 2016 Sep;26(9):1017-30. DMGNRZU RU https://www.ncbi.nlm.nih.gov/pubmed/27376512 DMWXEZD DI DMWXEZD DMWXEZD DN PMID27376512-Compound-MTC-427 DMWXEZD MI TT6S2FE DMWXEZD MN DNA [cytosine-5]-methyltransferase 1 (DNMT1) DMWXEZD MT DTT DMWXEZD MA Inhibitor DMWXEZD RN DNA methyltransferase inhibitors: an updated patent review (2012-2015).Expert Opin Ther Pat. 2016 Sep;26(9):1017-30. DMWXEZD RU https://www.ncbi.nlm.nih.gov/pubmed/27376512 DMWXEZD DI DMWXEZD DMWXEZD DN PMID27376512-Compound-MTC-427 DMWXEZD MI TTJUALD DMWXEZD MN DNA [cytosine-5]-methyltransferase 3A (DNMT3A) DMWXEZD MT DTT DMWXEZD MA Inhibitor DMWXEZD RN DNA methyltransferase inhibitors: an updated patent review (2012-2015).Expert Opin Ther Pat. 2016 Sep;26(9):1017-30. DMWXEZD RU https://www.ncbi.nlm.nih.gov/pubmed/27376512 DMWXEZD DI DMWXEZD DMWXEZD DN PMID27376512-Compound-MTC-427 DMWXEZD MI TT6VZ78 DMWXEZD MN DNA [cytosine-5]-methyltransferase 3B (DNMT3B) DMWXEZD MT DTT DMWXEZD MA Inhibitor DMWXEZD RN DNA methyltransferase inhibitors: an updated patent review (2012-2015).Expert Opin Ther Pat. 2016 Sep;26(9):1017-30. DMWXEZD RU https://www.ncbi.nlm.nih.gov/pubmed/27376512 DM7OS5E DI DM7OS5E DM7OS5E DN PMID27376512-Compound-MTC-433 DM7OS5E MI TT6S2FE DM7OS5E MN DNA [cytosine-5]-methyltransferase 1 (DNMT1) DM7OS5E MT DTT DM7OS5E MA Inhibitor DM7OS5E RN DNA methyltransferase inhibitors: an updated patent review (2012-2015).Expert Opin Ther Pat. 2016 Sep;26(9):1017-30. DM7OS5E RU https://www.ncbi.nlm.nih.gov/pubmed/27376512 DM70CTE DI DM70CTE DM70CTE DN PMID27376512-Compound-MTC-434 DM70CTE MI TTHVCUP DM70CTE MN DNA [cytosine-5]-methyltransferase (DNMT) DM70CTE MT DTT DM70CTE MA Inhibitor DM70CTE RN DNA methyltransferase inhibitors: an updated patent review (2012-2015).Expert Opin Ther Pat. 2016 Sep;26(9):1017-30. DM70CTE RU https://www.ncbi.nlm.nih.gov/pubmed/27376512 DM5K4YF DI DM5K4YF DM5K4YF DN PMID27376512-Compound-PG-11047 DM5K4YF MI TTHVCUP DM5K4YF MN DNA [cytosine-5]-methyltransferase (DNMT) DM5K4YF MT DTT DM5K4YF MA Inhibitor DM5K4YF RN DNA methyltransferase inhibitors: an updated patent review (2012-2015).Expert Opin Ther Pat. 2016 Sep;26(9):1017-30. DM5K4YF RU https://www.ncbi.nlm.nih.gov/pubmed/27376512 DM5K4YF DI DM5K4YF DM5K4YF DN PMID27376512-Compound-PG-11047 DM5K4YF MI TTBH0VX DM5K4YF MN Histone deacetylase (HDAC) DM5K4YF MT DTT DM5K4YF MA Inhibitor DM5K4YF RN DNA methyltransferase inhibitors: an updated patent review (2012-2015).Expert Opin Ther Pat. 2016 Sep;26(9):1017-30. DM5K4YF RU https://www.ncbi.nlm.nih.gov/pubmed/27376512 DM3U7RN DI DM3U7RN DM3U7RN DN PMID27376512-Compound-PG-11048 DM3U7RN MI TTHVCUP DM3U7RN MN DNA [cytosine-5]-methyltransferase (DNMT) DM3U7RN MT DTT DM3U7RN MA Inhibitor DM3U7RN RN DNA methyltransferase inhibitors: an updated patent review (2012-2015).Expert Opin Ther Pat. 2016 Sep;26(9):1017-30. DM3U7RN RU https://www.ncbi.nlm.nih.gov/pubmed/27376512 DM3U7RN DI DM3U7RN DM3U7RN DN PMID27376512-Compound-PG-11048 DM3U7RN MI TTBH0VX DM3U7RN MN Histone deacetylase (HDAC) DM3U7RN MT DTT DM3U7RN MA Inhibitor DM3U7RN RN DNA methyltransferase inhibitors: an updated patent review (2012-2015).Expert Opin Ther Pat. 2016 Sep;26(9):1017-30. DM3U7RN RU https://www.ncbi.nlm.nih.gov/pubmed/27376512 DMIFTUN DI DMIFTUN DMIFTUN DN PMID27376512-Compound-Table1Example11 DMIFTUN MI TT6S2FE DMIFTUN MN DNA [cytosine-5]-methyltransferase 1 (DNMT1) DMIFTUN MT DTT DMIFTUN MA Inhibitor DMIFTUN RN DNA methyltransferase inhibitors: an updated patent review (2012-2015).Expert Opin Ther Pat. 2016 Sep;26(9):1017-30. DMIFTUN RU https://www.ncbi.nlm.nih.gov/pubmed/27376512 DMM3VA8 DI DMM3VA8 DMM3VA8 DN PMID27376512-Compound-Table1Example16 DMM3VA8 MI TT6S2FE DMM3VA8 MN DNA [cytosine-5]-methyltransferase 1 (DNMT1) DMM3VA8 MT DTT DMM3VA8 MA Inhibitor DMM3VA8 RN DNA methyltransferase inhibitors: an updated patent review (2012-2015).Expert Opin Ther Pat. 2016 Sep;26(9):1017-30. DMM3VA8 RU https://www.ncbi.nlm.nih.gov/pubmed/27376512 DM5RX9D DI DM5RX9D DM5RX9D DN PMID27376512-Compound-Table1Example30 DM5RX9D MI TT6S2FE DM5RX9D MN DNA [cytosine-5]-methyltransferase 1 (DNMT1) DM5RX9D MT DTT DM5RX9D MA Inhibitor DM5RX9D RN DNA methyltransferase inhibitors: an updated patent review (2012-2015).Expert Opin Ther Pat. 2016 Sep;26(9):1017-30. DM5RX9D RU https://www.ncbi.nlm.nih.gov/pubmed/27376512 DMFJG7P DI DMFJG7P DMFJG7P DN PMID27376512-Compound-Table1Example4 DMFJG7P MI TT6S2FE DMFJG7P MN DNA [cytosine-5]-methyltransferase 1 (DNMT1) DMFJG7P MT DTT DMFJG7P MA Inhibitor DMFJG7P RN DNA methyltransferase inhibitors: an updated patent review (2012-2015).Expert Opin Ther Pat. 2016 Sep;26(9):1017-30. DMFJG7P RU https://www.ncbi.nlm.nih.gov/pubmed/27376512 DM4Q6XZ DI DM4Q6XZ DM4Q6XZ DN PMID27376512-Compound-Table1Example5 DM4Q6XZ MI TT6S2FE DM4Q6XZ MN DNA [cytosine-5]-methyltransferase 1 (DNMT1) DM4Q6XZ MT DTT DM4Q6XZ MA Inhibitor DM4Q6XZ RN DNA methyltransferase inhibitors: an updated patent review (2012-2015).Expert Opin Ther Pat. 2016 Sep;26(9):1017-30. DM4Q6XZ RU https://www.ncbi.nlm.nih.gov/pubmed/27376512 DMKU7GD DI DMKU7GD DMKU7GD DN PMID27376512-Compound-Table1Example8 DMKU7GD MI TT6S2FE DMKU7GD MN DNA [cytosine-5]-methyltransferase 1 (DNMT1) DMKU7GD MT DTT DMKU7GD MA Inhibitor DMKU7GD RN DNA methyltransferase inhibitors: an updated patent review (2012-2015).Expert Opin Ther Pat. 2016 Sep;26(9):1017-30. DMKU7GD RU https://www.ncbi.nlm.nih.gov/pubmed/27376512 DMD4CIU DI DMD4CIU DMD4CIU DN PMID27387065-Compound-6 DMD4CIU MI TTK25J1 DMD4CIU MN Adenosine A1 receptor (ADORA1) DMD4CIU MT DTT DMD4CIU MA Agonist DMD4CIU RN Carbonic anhydrase inhibitors: a review on the progress of patent literature (2011-2016).Expert Opin Ther Pat. 2016 Aug;26(8):947-56. DMD4CIU RU https://www.ncbi.nlm.nih.gov/pubmed/27387065 DMDQMZT DI DMDQMZT DMDQMZT DN PMID27410995-Compound-Figure3c DMDQMZT MI TTG0U4H DMDQMZT MN Ribosomal protein S6 kinase beta-1 (S6K1) DMDQMZT MT DTT DMDQMZT MA Inhibitor DMDQMZT RN Ribosomal S6 kinase (RSK) modulators: a patent review.Expert Opin Ther Pat. 2016 Sep;26(9):1061-78. DMDQMZT RU https://www.ncbi.nlm.nih.gov/pubmed/27410995 DMJRZLB DI DMJRZLB DMJRZLB DN PMID27410995-Compound-Figure3j DMJRZLB MI TTUM2ZR DMJRZLB MN Ribosomal protein S6 kinase alpha-3 (RSK3) DMJRZLB MT DTT DMJRZLB MA Inhibitor DMJRZLB RN Ribosomal S6 kinase (RSK) modulators: a patent review.Expert Opin Ther Pat. 2016 Sep;26(9):1061-78. DMJRZLB RU https://www.ncbi.nlm.nih.gov/pubmed/27410995 DMJRZLB DI DMJRZLB DMJRZLB DN PMID27410995-Compound-Figure3j DMJRZLB MI TT9ABMF DMJRZLB MN Serine/threonine-protein kinase Chk2 (RAD53) DMJRZLB MT DTT DMJRZLB MA Inhibitor DMJRZLB RN Ribosomal S6 kinase (RSK) modulators: a patent review.Expert Opin Ther Pat. 2016 Sep;26(9):1061-78. DMJRZLB RU https://www.ncbi.nlm.nih.gov/pubmed/27410995 DMJ0QLB DI DMJ0QLB DMJ0QLB DN PMID27410995-Compound-Figure3k DMJ0QLB MI TT7M3PI DMJ0QLB MN Ribosomal protein S6 kinase (S6K) DMJ0QLB MT DTT DMJ0QLB MA Activator DMJ0QLB RN Ribosomal S6 kinase (RSK) modulators: a patent review.Expert Opin Ther Pat. 2016 Sep;26(9):1061-78. DMJ0QLB RU https://www.ncbi.nlm.nih.gov/pubmed/27410995 DMUG9X0 DI DMUG9X0 DMUG9X0 DN PMID27414413-Compound-Figure6right DMUG9X0 MI TTA592U DMUG9X0 MN Urate anion exchanger 1 (URAT1) DMUG9X0 MT DTT DMUG9X0 MA Inhibitor DMUG9X0 RN Urate transporter URAT1 inhibitors: a patent review (2012 - 2015).Expert Opin Ther Pat. 2016 Jul 30:1-10. DMUG9X0 RU https://www.ncbi.nlm.nih.gov/pubmed/27414413 DMTZNSM DI DMTZNSM DMTZNSM DN PMID27414413-Compound-Figure8right DMTZNSM MI TTA592U DMTZNSM MN Urate anion exchanger 1 (URAT1) DMTZNSM MT DTT DMTZNSM MA Inhibitor DMTZNSM RN Urate transporter URAT1 inhibitors: a patent review (2012 - 2015).Expert Opin Ther Pat. 2016 Jul 30:1-10. DMTZNSM RU https://www.ncbi.nlm.nih.gov/pubmed/27414413 DM5LOST DI DM5LOST DM5LOST DN PMID27454349-Compound-100 DM5LOST MI TTK59TV DM5LOST MN Vitamin D3 receptor (VDR) DM5LOST MT DTT DM5LOST MA Agonist DM5LOST RN Vitamin D receptor 2016: novel ligands and structural insights.Expert Opin Ther Pat. 2016 Nov;26(11):1291-1306. DM5LOST RU https://www.ncbi.nlm.nih.gov/pubmed/27454349 DMQIYM6 DI DMQIYM6 DMQIYM6 DN PMID27454349-Compound-101 DMQIYM6 MI TTK59TV DMQIYM6 MN Vitamin D3 receptor (VDR) DMQIYM6 MT DTT DMQIYM6 MA Agonist DMQIYM6 RN Vitamin D receptor 2016: novel ligands and structural insights.Expert Opin Ther Pat. 2016 Nov;26(11):1291-1306. DMQIYM6 RU https://www.ncbi.nlm.nih.gov/pubmed/27454349 DMEGRMX DI DMEGRMX DMEGRMX DN PMID27454349-Compound-102 DMEGRMX MI TTK59TV DMEGRMX MN Vitamin D3 receptor (VDR) DMEGRMX MT DTT DMEGRMX MA Agonist DMEGRMX RN Vitamin D receptor 2016: novel ligands and structural insights.Expert Opin Ther Pat. 2016 Nov;26(11):1291-1306. DMEGRMX RU https://www.ncbi.nlm.nih.gov/pubmed/27454349 DMAN7CG DI DMAN7CG DMAN7CG DN PMID27454349-Compound-91 DMAN7CG MI TTK59TV DMAN7CG MN Vitamin D3 receptor (VDR) DMAN7CG MT DTT DMAN7CG MA Agonist DMAN7CG RN Vitamin D receptor 2016: novel ligands and structural insights.Expert Opin Ther Pat. 2016 Nov;26(11):1291-1306. DMAN7CG RU https://www.ncbi.nlm.nih.gov/pubmed/27454349 DMOEYVT DI DMOEYVT DMOEYVT DN PMID27454349-Compound-92 DMOEYVT MI TTK59TV DMOEYVT MN Vitamin D3 receptor (VDR) DMOEYVT MT DTT DMOEYVT MA Agonist DMOEYVT RN Vitamin D receptor 2016: novel ligands and structural insights.Expert Opin Ther Pat. 2016 Nov;26(11):1291-1306. DMOEYVT RU https://www.ncbi.nlm.nih.gov/pubmed/27454349 DMCTMB1 DI DMCTMB1 DMCTMB1 DN PMID27454349-Compound-93 DMCTMB1 MI TTK59TV DMCTMB1 MN Vitamin D3 receptor (VDR) DMCTMB1 MT DTT DMCTMB1 MA Agonist DMCTMB1 RN Vitamin D receptor 2016: novel ligands and structural insights.Expert Opin Ther Pat. 2016 Nov;26(11):1291-1306. DMCTMB1 RU https://www.ncbi.nlm.nih.gov/pubmed/27454349 DMK0SIM DI DMK0SIM DMK0SIM DN PMID27454349-Compound-94 DMK0SIM MI TTK59TV DMK0SIM MN Vitamin D3 receptor (VDR) DMK0SIM MT DTT DMK0SIM MA Agonist DMK0SIM RN Vitamin D receptor 2016: novel ligands and structural insights.Expert Opin Ther Pat. 2016 Nov;26(11):1291-1306. DMK0SIM RU https://www.ncbi.nlm.nih.gov/pubmed/27454349 DM17KL2 DI DM17KL2 DM17KL2 DN PMID27454349-Compound-95 DM17KL2 MI TTK59TV DM17KL2 MN Vitamin D3 receptor (VDR) DM17KL2 MT DTT DM17KL2 MA Agonist DM17KL2 RN Vitamin D receptor 2016: novel ligands and structural insights.Expert Opin Ther Pat. 2016 Nov;26(11):1291-1306. DM17KL2 RU https://www.ncbi.nlm.nih.gov/pubmed/27454349 DMW0TM1 DI DMW0TM1 DMW0TM1 DN PMID27454349-Compound-96 DMW0TM1 MI TTK59TV DMW0TM1 MN Vitamin D3 receptor (VDR) DMW0TM1 MT DTT DMW0TM1 MA Agonist DMW0TM1 RN Vitamin D receptor 2016: novel ligands and structural insights.Expert Opin Ther Pat. 2016 Nov;26(11):1291-1306. DMW0TM1 RU https://www.ncbi.nlm.nih.gov/pubmed/27454349 DMEXV6L DI DMEXV6L DMEXV6L DN PMID27454349-Compound-97 DMEXV6L MI TTK59TV DMEXV6L MN Vitamin D3 receptor (VDR) DMEXV6L MT DTT DMEXV6L MA Agonist DMEXV6L RN Vitamin D receptor 2016: novel ligands and structural insights.Expert Opin Ther Pat. 2016 Nov;26(11):1291-1306. DMEXV6L RU https://www.ncbi.nlm.nih.gov/pubmed/27454349 DMZKYMI DI DMZKYMI DMZKYMI DN PMID27454349-Compound-98 DMZKYMI MI TTK59TV DMZKYMI MN Vitamin D3 receptor (VDR) DMZKYMI MT DTT DMZKYMI MA Agonist DMZKYMI RN Vitamin D receptor 2016: novel ligands and structural insights.Expert Opin Ther Pat. 2016 Nov;26(11):1291-1306. DMZKYMI RU https://www.ncbi.nlm.nih.gov/pubmed/27454349 DMH0CQU DI DMH0CQU DMH0CQU DN PMID27454349-Compound-99 DMH0CQU MI TTK59TV DMH0CQU MN Vitamin D3 receptor (VDR) DMH0CQU MT DTT DMH0CQU MA Agonist DMH0CQU RN Vitamin D receptor 2016: novel ligands and structural insights.Expert Opin Ther Pat. 2016 Nov;26(11):1291-1306. DMH0CQU RU https://www.ncbi.nlm.nih.gov/pubmed/27454349 DM9C4XH DI DM9C4XH DM9C4XH DN PMID27537201-Compound-Figure11 DM9C4XH MI TTPADOQ DM9C4XH MN HMG-CoA reductase (HMGCR) DM9C4XH MT DTT DM9C4XH MA Inhibitor DM9C4XH RN HMG-CoA Reductase inhibitors: an updated review of patents of novel compounds and formulations (2011-2015).Expert Opin Ther Pat. 2016 Nov;26(11):1257-1272. DM9C4XH RU https://www.ncbi.nlm.nih.gov/pubmed/27537201 DMPDTHQ DI DMPDTHQ DMPDTHQ DN PMID27537201-Compound-Figure13b DMPDTHQ MI TTPADOQ DMPDTHQ MN HMG-CoA reductase (HMGCR) DMPDTHQ MT DTT DMPDTHQ MA Inhibitor DMPDTHQ RN HMG-CoA Reductase inhibitors: an updated review of patents of novel compounds and formulations (2011-2015).Expert Opin Ther Pat. 2016 Nov;26(11):1257-1272. DMPDTHQ RU https://www.ncbi.nlm.nih.gov/pubmed/27537201 DMWZ1PD DI DMWZ1PD DMWZ1PD DN PMID27537201-Compound-Figure13c DMWZ1PD MI TTPADOQ DMWZ1PD MN HMG-CoA reductase (HMGCR) DMWZ1PD MT DTT DMWZ1PD MA Inhibitor DMWZ1PD RN HMG-CoA Reductase inhibitors: an updated review of patents of novel compounds and formulations (2011-2015).Expert Opin Ther Pat. 2016 Nov;26(11):1257-1272. DMWZ1PD RU https://www.ncbi.nlm.nih.gov/pubmed/27537201 DMVBJKH DI DMVBJKH DMVBJKH DN PMID27537201-Compound-Figure15a DMVBJKH MI TTPADOQ DMVBJKH MN HMG-CoA reductase (HMGCR) DMVBJKH MT DTT DMVBJKH MA Inhibitor DMVBJKH RN HMG-CoA Reductase inhibitors: an updated review of patents of novel compounds and formulations (2011-2015).Expert Opin Ther Pat. 2016 Nov;26(11):1257-1272. DMVBJKH RU https://www.ncbi.nlm.nih.gov/pubmed/27537201 DMZ6N2J DI DMZ6N2J DMZ6N2J DN PMID27537201-Compound-Figure15b DMZ6N2J MI TTPADOQ DMZ6N2J MN HMG-CoA reductase (HMGCR) DMZ6N2J MT DTT DMZ6N2J MA Inhibitor DMZ6N2J RN HMG-CoA Reductase inhibitors: an updated review of patents of novel compounds and formulations (2011-2015).Expert Opin Ther Pat. 2016 Nov;26(11):1257-1272. DMZ6N2J RU https://www.ncbi.nlm.nih.gov/pubmed/27537201 DMWKVZD DI DMWKVZD DMWKVZD DN PMID27537201-Compound-Figure17 DMWKVZD MI TTPADOQ DMWKVZD MN HMG-CoA reductase (HMGCR) DMWKVZD MT DTT DMWKVZD MA Inhibitor DMWKVZD RN HMG-CoA Reductase inhibitors: an updated review of patents of novel compounds and formulations (2011-2015).Expert Opin Ther Pat. 2016 Nov;26(11):1257-1272. DMWKVZD RU https://www.ncbi.nlm.nih.gov/pubmed/27537201 DM61SR0 DI DM61SR0 DM61SR0 DN PMID27539678-Compound-10 DM61SR0 MI TTOHFIY DM61SR0 MN Sphingosine kinase 1 (SPHK1) DM61SR0 MT DTT DM61SR0 MA Inhibitor DM61SR0 RN Sphingosine kinase inhibitors: a review of patent literature (2006-2015).Expert Opin Ther Pat. 2016 Dec;26(12):1409-1416. DM61SR0 RU https://www.ncbi.nlm.nih.gov/pubmed/27539678 DMIKAJC DI DMIKAJC DMIKAJC DN PMID27539678-Compound-11 DMIKAJC MI TTOHFIY DMIKAJC MN Sphingosine kinase 1 (SPHK1) DMIKAJC MT DTT DMIKAJC MA Inhibitor DMIKAJC RN Sphingosine kinase inhibitors: a review of patent literature (2006-2015).Expert Opin Ther Pat. 2016 Dec;26(12):1409-1416. DMIKAJC RU https://www.ncbi.nlm.nih.gov/pubmed/27539678 DMNIKTA DI DMNIKTA DMNIKTA DN PMID27539678-Compound-12 DMNIKTA MI TTOHFIY DMNIKTA MN Sphingosine kinase 1 (SPHK1) DMNIKTA MT DTT DMNIKTA MA Inhibitor DMNIKTA RN Sphingosine kinase inhibitors: a review of patent literature (2006-2015).Expert Opin Ther Pat. 2016 Dec;26(12):1409-1416. DMNIKTA RU https://www.ncbi.nlm.nih.gov/pubmed/27539678 DM1J2V8 DI DM1J2V8 DM1J2V8 DN PMID27539678-Compound-13 DM1J2V8 MI TTOHFIY DM1J2V8 MN Sphingosine kinase 1 (SPHK1) DM1J2V8 MT DTT DM1J2V8 MA Inhibitor DM1J2V8 RN Sphingosine kinase inhibitors: a review of patent literature (2006-2015).Expert Opin Ther Pat. 2016 Dec;26(12):1409-1416. DM1J2V8 RU https://www.ncbi.nlm.nih.gov/pubmed/27539678 DMZ02LA DI DMZ02LA DMZ02LA DN PMID27539678-Compound-14 DMZ02LA MI TTOHFIY DMZ02LA MN Sphingosine kinase 1 (SPHK1) DMZ02LA MT DTT DMZ02LA MA Inhibitor DMZ02LA RN Sphingosine kinase inhibitors: a review of patent literature (2006-2015).Expert Opin Ther Pat. 2016 Dec;26(12):1409-1416. DMZ02LA RU https://www.ncbi.nlm.nih.gov/pubmed/27539678 DMMDJH8 DI DMMDJH8 DMMDJH8 DN PMID27539678-Compound-16 DMMDJH8 MI TTOHFIY DMMDJH8 MN Sphingosine kinase 1 (SPHK1) DMMDJH8 MT DTT DMMDJH8 MA Inhibitor DMMDJH8 RN Sphingosine kinase inhibitors: a review of patent literature (2006-2015).Expert Opin Ther Pat. 2016 Dec;26(12):1409-1416. DMMDJH8 RU https://www.ncbi.nlm.nih.gov/pubmed/27539678 DMVG7A5 DI DMVG7A5 DMVG7A5 DN PMID27539678-Compound-17 DMVG7A5 MI TTOHFIY DMVG7A5 MN Sphingosine kinase 1 (SPHK1) DMVG7A5 MT DTT DMVG7A5 MA Inhibitor DMVG7A5 RN Sphingosine kinase inhibitors: a review of patent literature (2006-2015).Expert Opin Ther Pat. 2016 Dec;26(12):1409-1416. DMVG7A5 RU https://www.ncbi.nlm.nih.gov/pubmed/27539678 DMRNBP3 DI DMRNBP3 DMRNBP3 DN PMID27539678-Compound-3 DMRNBP3 MI TT3M2WO DMRNBP3 MN Sphingosine kinase (SphK) DMRNBP3 MT DTT DMRNBP3 MA Inhibitor DMRNBP3 RN Sphingosine kinase inhibitors: a review of patent literature (2006-2015).Expert Opin Ther Pat. 2016 Dec;26(12):1409-1416. DMRNBP3 RU https://www.ncbi.nlm.nih.gov/pubmed/27539678 DMJ8BAS DI DMJ8BAS DMJ8BAS DN PMID27539678-Compound-4 DMJ8BAS MI TT3M2WO DMJ8BAS MN Sphingosine kinase (SphK) DMJ8BAS MT DTT DMJ8BAS MA Inhibitor DMJ8BAS RN Sphingosine kinase inhibitors: a review of patent literature (2006-2015).Expert Opin Ther Pat. 2016 Dec;26(12):1409-1416. DMJ8BAS RU https://www.ncbi.nlm.nih.gov/pubmed/27539678 DMBKNDE DI DMBKNDE DMBKNDE DN PMID27539678-Compound-6 DMBKNDE MI TTOHFIY DMBKNDE MN Sphingosine kinase 1 (SPHK1) DMBKNDE MT DTT DMBKNDE MA Inhibitor DMBKNDE RN Sphingosine kinase inhibitors: a review of patent literature (2006-2015).Expert Opin Ther Pat. 2016 Dec;26(12):1409-1416. DMBKNDE RU https://www.ncbi.nlm.nih.gov/pubmed/27539678 DMQAC4K DI DMQAC4K DMQAC4K DN PMID27539678-Compound-7 DMQAC4K MI TTOHFIY DMQAC4K MN Sphingosine kinase 1 (SPHK1) DMQAC4K MT DTT DMQAC4K MA Inhibitor DMQAC4K RN Sphingosine kinase inhibitors: a review of patent literature (2006-2015).Expert Opin Ther Pat. 2016 Dec;26(12):1409-1416. DMQAC4K RU https://www.ncbi.nlm.nih.gov/pubmed/27539678 DMHWUEV DI DMHWUEV DMHWUEV DN PMID27539678-Compound-8 DMHWUEV MI TT3M2WO DMHWUEV MN Sphingosine kinase (SphK) DMHWUEV MT DTT DMHWUEV MA Inhibitor DMHWUEV RN Sphingosine kinase inhibitors: a review of patent literature (2006-2015).Expert Opin Ther Pat. 2016 Dec;26(12):1409-1416. DMHWUEV RU https://www.ncbi.nlm.nih.gov/pubmed/27539678 DM0Y5NU DI DM0Y5NU DM0Y5NU DN PMID27539678-Compound-9 DM0Y5NU MI TTOHFIY DM0Y5NU MN Sphingosine kinase 1 (SPHK1) DM0Y5NU MT DTT DM0Y5NU MA Inhibitor DM0Y5NU RN Sphingosine kinase inhibitors: a review of patent literature (2006-2015).Expert Opin Ther Pat. 2016 Dec;26(12):1409-1416. DM0Y5NU RU https://www.ncbi.nlm.nih.gov/pubmed/27539678 DM5OQBR DI DM5OQBR DM5OQBR DN PMID27551786-Compound-106 DM5OQBR MI TT26PHO DM5OQBR MN Mineralocorticoid receptor (MR) DM5OQBR MT DTT DM5OQBR MA Antagonist DM5OQBR RN Mineralocorticoid receptor antagonists: a patent evaluation of US20150284376A1.Expert Opin Ther Pat. 2016 Sep 14:1-4. DM5OQBR RU https://www.ncbi.nlm.nih.gov/pubmed/27551786 DM4IZUH DI DM4IZUH DM4IZUH DN PMID27551786-Compound-138 DM4IZUH MI TT26PHO DM4IZUH MN Mineralocorticoid receptor (MR) DM4IZUH MT DTT DM4IZUH MA Antagonist DM4IZUH RN Mineralocorticoid receptor antagonists: a patent evaluation of US20150284376A1.Expert Opin Ther Pat. 2016 Sep 14:1-4. DM4IZUH RU https://www.ncbi.nlm.nih.gov/pubmed/27551786 DMA7H63 DI DMA7H63 DMA7H63 DN PMID27551786-Compound-I DMA7H63 MI TT26PHO DMA7H63 MN Mineralocorticoid receptor (MR) DMA7H63 MT DTT DMA7H63 MA Antagonist DMA7H63 RN Mineralocorticoid receptor antagonists: a patent evaluation of US20150284376A1.Expert Opin Ther Pat. 2016 Sep 14:1-4. DMA7H63 RU https://www.ncbi.nlm.nih.gov/pubmed/27551786 DMJADXV DI DMJADXV DMJADXV DN PMID27551786-Compound-II DMJADXV MI TT26PHO DMJADXV MN Mineralocorticoid receptor (MR) DMJADXV MT DTT DMJADXV MA Antagonist DMJADXV RN Mineralocorticoid receptor antagonists: a patent evaluation of US20150284376A1.Expert Opin Ther Pat. 2016 Sep 14:1-4. DMJADXV RU https://www.ncbi.nlm.nih.gov/pubmed/27551786 DMBQ981 DI DMBQ981 DMBQ981 DN PMID27551786-Compound-III DMBQ981 MI TT26PHO DMBQ981 MN Mineralocorticoid receptor (MR) DMBQ981 MT DTT DMBQ981 MA Antagonist DMBQ981 RN Mineralocorticoid receptor antagonists: a patent evaluation of US20150284376A1.Expert Opin Ther Pat. 2016 Sep 14:1-4. DMBQ981 RU https://www.ncbi.nlm.nih.gov/pubmed/27551786 DM7IB8L DI DM7IB8L DM7IB8L DN PMID27551786-Compound-IV DM7IB8L MI TT26PHO DM7IB8L MN Mineralocorticoid receptor (MR) DM7IB8L MT DTT DM7IB8L MA Antagonist DM7IB8L RN Mineralocorticoid receptor antagonists: a patent evaluation of US20150284376A1.Expert Opin Ther Pat. 2016 Sep 14:1-4. DM7IB8L RU https://www.ncbi.nlm.nih.gov/pubmed/27551786 DM5KARO DI DM5KARO DM5KARO DN PMID27599163-Compound-52 DM5KARO MI TTPTXIN DM5KARO MN Translocator protein (TSPO) DM5KARO MT DTT DM5KARO MA Ligand DM5KARO RN Translocator protein (TSPO) ligands for the diagnosis or treatment of neurodegenerative diseases: a patent review (2010 - 2015; part 2).Expert Opin Ther Pat. 2016 Nov;26(11):1353-1366. DM5KARO RU https://www.ncbi.nlm.nih.gov/pubmed/27599163 DMYCQR4 DI DMYCQR4 DMYCQR4 DN PMID27599163-Compound-75 DMYCQR4 MI TTPTXIN DMYCQR4 MN Translocator protein (TSPO) DMYCQR4 MT DTT DMYCQR4 MA Ligand DMYCQR4 RN Translocator protein (TSPO) ligands for the diagnosis or treatment of neurodegenerative diseases: a patent review (2010 - 2015; part 2).Expert Opin Ther Pat. 2016 Nov;26(11):1353-1366. DMYCQR4 RU https://www.ncbi.nlm.nih.gov/pubmed/27599163 DMODPFU DI DMODPFU DMODPFU DN PMID27599163-Compound-76 DMODPFU MI TTPTXIN DMODPFU MN Translocator protein (TSPO) DMODPFU MT DTT DMODPFU MA Ligand DMODPFU RN Translocator protein (TSPO) ligands for the diagnosis or treatment of neurodegenerative diseases: a patent review (2010 - 2015; part 2).Expert Opin Ther Pat. 2016 Nov;26(11):1353-1366. DMODPFU RU https://www.ncbi.nlm.nih.gov/pubmed/27599163 DM2TNH4 DI DM2TNH4 DM2TNH4 DN PMID27599163-Compound-77 DM2TNH4 MI TTPTXIN DM2TNH4 MN Translocator protein (TSPO) DM2TNH4 MT DTT DM2TNH4 MA Ligand DM2TNH4 RN Translocator protein (TSPO) ligands for the diagnosis or treatment of neurodegenerative diseases: a patent review (2010 - 2015; part 2).Expert Opin Ther Pat. 2016 Nov;26(11):1353-1366. DM2TNH4 RU https://www.ncbi.nlm.nih.gov/pubmed/27599163 DMZC58R DI DMZC58R DMZC58R DN PMID27599163-Compound-78 DMZC58R MI TTPTXIN DMZC58R MN Translocator protein (TSPO) DMZC58R MT DTT DMZC58R MA Ligand DMZC58R RN Translocator protein (TSPO) ligands for the diagnosis or treatment of neurodegenerative diseases: a patent review (2010 - 2015; part 2).Expert Opin Ther Pat. 2016 Nov;26(11):1353-1366. DMZC58R RU https://www.ncbi.nlm.nih.gov/pubmed/27599163 DMVUWYB DI DMVUWYB DMVUWYB DN PMID27599163-Compound-79 DMVUWYB MI TTPTXIN DMVUWYB MN Translocator protein (TSPO) DMVUWYB MT DTT DMVUWYB MA Ligand DMVUWYB RN Translocator protein (TSPO) ligands for the diagnosis or treatment of neurodegenerative diseases: a patent review (2010 - 2015; part 2).Expert Opin Ther Pat. 2016 Nov;26(11):1353-1366. DMVUWYB RU https://www.ncbi.nlm.nih.gov/pubmed/27599163 DMZ5QC4 DI DMZ5QC4 DMZ5QC4 DN PMID27599163-Compound-81 DMZ5QC4 MI TTPTXIN DMZ5QC4 MN Translocator protein (TSPO) DMZ5QC4 MT DTT DMZ5QC4 MA Ligand DMZ5QC4 RN Translocator protein (TSPO) ligands for the diagnosis or treatment of neurodegenerative diseases: a patent review (2010 - 2015; part 2).Expert Opin Ther Pat. 2016 Nov;26(11):1353-1366. DMZ5QC4 RU https://www.ncbi.nlm.nih.gov/pubmed/27599163 DMO74I9 DI DMO74I9 DMO74I9 DN PMID27599163-Compound-82 DMO74I9 MI TTPTXIN DMO74I9 MN Translocator protein (TSPO) DMO74I9 MT DTT DMO74I9 MA Ligand DMO74I9 RN Translocator protein (TSPO) ligands for the diagnosis or treatment of neurodegenerative diseases: a patent review (2010 - 2015; part 2).Expert Opin Ther Pat. 2016 Nov;26(11):1353-1366. DMO74I9 RU https://www.ncbi.nlm.nih.gov/pubmed/27599163 DM5RBFC DI DM5RBFC DM5RBFC DN PMID27607364-Compound-10 DM5RBFC MI TTPTXIN DM5RBFC MN Translocator protein (TSPO) DM5RBFC MT DTT DM5RBFC MA Ligand DM5RBFC RN Translocator protein (TSPO) ligands for the diagnosis or treatment of neurodegenerative diseases: a patent review (2010-2015; part 1).Expert Opin Ther Pat. 2016 Nov;26(11):1325-1351. DM5RBFC RU https://www.ncbi.nlm.nih.gov/pubmed/27607364 DMMF4XO DI DMMF4XO DMMF4XO DN PMID27607364-Compound-141 DMMF4XO MI TTPTXIN DMMF4XO MN Translocator protein (TSPO) DMMF4XO MT DTT DMMF4XO MA Ligand DMMF4XO RN Translocator protein (TSPO) ligands for the diagnosis or treatment of neurodegenerative diseases: a patent review (2010-2015; part 1).Expert Opin Ther Pat. 2016 Nov;26(11):1325-1351. DMMF4XO RU https://www.ncbi.nlm.nih.gov/pubmed/27607364 DM0F6VU DI DM0F6VU DM0F6VU DN PMID27607364-Compound-162 DM0F6VU MI TTPTXIN DM0F6VU MN Translocator protein (TSPO) DM0F6VU MT DTT DM0F6VU MA Ligand DM0F6VU RN Translocator protein (TSPO) ligands for the diagnosis or treatment of neurodegenerative diseases: a patent review (2010-2015; part 1).Expert Opin Ther Pat. 2016 Nov;26(11):1325-1351. DM0F6VU RU https://www.ncbi.nlm.nih.gov/pubmed/27607364 DMKBZDP DI DMKBZDP DMKBZDP DN PMID27607364-Compound-4 DMKBZDP MI TTPTXIN DMKBZDP MN Translocator protein (TSPO) DMKBZDP MT DTT DMKBZDP MA Ligand DMKBZDP RN Translocator protein (TSPO) ligands for the diagnosis or treatment of neurodegenerative diseases: a patent review (2010-2015; part 1).Expert Opin Ther Pat. 2016 Nov;26(11):1325-1351. DMKBZDP RU https://www.ncbi.nlm.nih.gov/pubmed/27607364 DMXJVW4 DI DMXJVW4 DMXJVW4 DN PMID27607364-Compound-58 DMXJVW4 MI TTPTXIN DMXJVW4 MN Translocator protein (TSPO) DMXJVW4 MT DTT DMXJVW4 MA Ligand DMXJVW4 RN Translocator protein (TSPO) ligands for the diagnosis or treatment of neurodegenerative diseases: a patent review (2010-2015; part 1).Expert Opin Ther Pat. 2016 Nov;26(11):1325-1351. DMXJVW4 RU https://www.ncbi.nlm.nih.gov/pubmed/27607364 DMLY7I3 DI DMLY7I3 DMLY7I3 DN PMID27607364-Compound-59 DMLY7I3 MI TTPTXIN DMLY7I3 MN Translocator protein (TSPO) DMLY7I3 MT DTT DMLY7I3 MA Ligand DMLY7I3 RN Translocator protein (TSPO) ligands for the diagnosis or treatment of neurodegenerative diseases: a patent review (2010-2015; part 1).Expert Opin Ther Pat. 2016 Nov;26(11):1325-1351. DMLY7I3 RU https://www.ncbi.nlm.nih.gov/pubmed/27607364 DM584EP DI DM584EP DM584EP DN PMID27607364-Compound-60 DM584EP MI TTPTXIN DM584EP MN Translocator protein (TSPO) DM584EP MT DTT DM584EP MA Ligand DM584EP RN Translocator protein (TSPO) ligands for the diagnosis or treatment of neurodegenerative diseases: a patent review (2010-2015; part 1).Expert Opin Ther Pat. 2016 Nov;26(11):1325-1351. DM584EP RU https://www.ncbi.nlm.nih.gov/pubmed/27607364 DMWE6NZ DI DMWE6NZ DMWE6NZ DN PMID27607364-Compound-61 DMWE6NZ MI TTPTXIN DMWE6NZ MN Translocator protein (TSPO) DMWE6NZ MT DTT DMWE6NZ MA Ligand DMWE6NZ RN Translocator protein (TSPO) ligands for the diagnosis or treatment of neurodegenerative diseases: a patent review (2010-2015; part 1).Expert Opin Ther Pat. 2016 Nov;26(11):1325-1351. DMWE6NZ RU https://www.ncbi.nlm.nih.gov/pubmed/27607364 DMXGT2A DI DMXGT2A DMXGT2A DN PMID27607364-Compound-62 DMXGT2A MI TTPTXIN DMXGT2A MN Translocator protein (TSPO) DMXGT2A MT DTT DMXGT2A MA Ligand DMXGT2A RN Translocator protein (TSPO) ligands for the diagnosis or treatment of neurodegenerative diseases: a patent review (2010-2015; part 1).Expert Opin Ther Pat. 2016 Nov;26(11):1325-1351. DMXGT2A RU https://www.ncbi.nlm.nih.gov/pubmed/27607364 DMVTPHY DI DMVTPHY DMVTPHY DN PMID27607364-Compound-63 DMVTPHY MI TTPTXIN DMVTPHY MN Translocator protein (TSPO) DMVTPHY MT DTT DMVTPHY MA Ligand DMVTPHY RN Translocator protein (TSPO) ligands for the diagnosis or treatment of neurodegenerative diseases: a patent review (2010-2015; part 1).Expert Opin Ther Pat. 2016 Nov;26(11):1325-1351. DMVTPHY RU https://www.ncbi.nlm.nih.gov/pubmed/27607364 DMZSI15 DI DMZSI15 DMZSI15 DN PMID27607364-Compound-64 DMZSI15 MI TTPTXIN DMZSI15 MN Translocator protein (TSPO) DMZSI15 MT DTT DMZSI15 MA Ligand DMZSI15 RN Translocator protein (TSPO) ligands for the diagnosis or treatment of neurodegenerative diseases: a patent review (2010-2015; part 1).Expert Opin Ther Pat. 2016 Nov;26(11):1325-1351. DMZSI15 RU https://www.ncbi.nlm.nih.gov/pubmed/27607364 DM9NEFG DI DM9NEFG DM9NEFG DN PMID27607364-Compound-65 DM9NEFG MI TTPTXIN DM9NEFG MN Translocator protein (TSPO) DM9NEFG MT DTT DM9NEFG MA Ligand DM9NEFG RN Translocator protein (TSPO) ligands for the diagnosis or treatment of neurodegenerative diseases: a patent review (2010-2015; part 1).Expert Opin Ther Pat. 2016 Nov;26(11):1325-1351. DM9NEFG RU https://www.ncbi.nlm.nih.gov/pubmed/27607364 DMTJ0LB DI DMTJ0LB DMTJ0LB DN PMID27724045-Compound-14 DMTJ0LB MI TT473XN DMTJ0LB MN P2X purinoceptor 7 (P2RX7) DMTJ0LB MT DTT DMTJ0LB MA Antagonist DMTJ0LB RN P2X7 receptor antagonists: a patent review (2010-2015).Expert Opin Ther Pat. 2017 Mar;27(3):257-267. DMTJ0LB RU https://www.ncbi.nlm.nih.gov/pubmed/27724045 DMVN5BD DI DMVN5BD DMVN5BD DN PMID27724045-Compound-15 DMVN5BD MI TT473XN DMVN5BD MN P2X purinoceptor 7 (P2RX7) DMVN5BD MT DTT DMVN5BD MA Antagonist DMVN5BD RN P2X7 receptor antagonists: a patent review (2010-2015).Expert Opin Ther Pat. 2017 Mar;27(3):257-267. DMVN5BD RU https://www.ncbi.nlm.nih.gov/pubmed/27724045 DM4W72V DI DM4W72V DM4W72V DN PMID27724045-Compound-17 DM4W72V MI TT473XN DM4W72V MN P2X purinoceptor 7 (P2RX7) DM4W72V MT DTT DM4W72V MA Antagonist DM4W72V RN P2X7 receptor antagonists: a patent review (2010-2015).Expert Opin Ther Pat. 2017 Mar;27(3):257-267. DM4W72V RU https://www.ncbi.nlm.nih.gov/pubmed/27724045 DMVDBHT DI DMVDBHT DMVDBHT DN PMID27724045-Compound-19 DMVDBHT MI TT473XN DMVDBHT MN P2X purinoceptor 7 (P2RX7) DMVDBHT MT DTT DMVDBHT MA Antagonist DMVDBHT RN P2X7 receptor antagonists: a patent review (2010-2015).Expert Opin Ther Pat. 2017 Mar;27(3):257-267. DMVDBHT RU https://www.ncbi.nlm.nih.gov/pubmed/27724045 DMKTQX8 DI DMKTQX8 DMKTQX8 DN PMID27724045-Compound-29 DMKTQX8 MI TT473XN DMKTQX8 MN P2X purinoceptor 7 (P2RX7) DMKTQX8 MT DTT DMKTQX8 MA Antagonist DMKTQX8 RN P2X7 receptor antagonists: a patent review (2010-2015).Expert Opin Ther Pat. 2017 Mar;27(3):257-267. DMKTQX8 RU https://www.ncbi.nlm.nih.gov/pubmed/27724045 DMOS7ZP DI DMOS7ZP DMOS7ZP DN PMID27724045-Compound-33 DMOS7ZP MI TT473XN DMOS7ZP MN P2X purinoceptor 7 (P2RX7) DMOS7ZP MT DTT DMOS7ZP MA Antagonist DMOS7ZP RN P2X7 receptor antagonists: a patent review (2010-2015).Expert Opin Ther Pat. 2017 Mar;27(3):257-267. DMOS7ZP RU https://www.ncbi.nlm.nih.gov/pubmed/27724045 DMFKS2P DI DMFKS2P DMFKS2P DN PMID27744724-Compound-10 DMFKS2P MI TTJGNVC DMFKS2P MN Apoptosis regulator Bcl-2 (BCL-2) DMFKS2P MT DTT DMFKS2P MA Inhibitor DMFKS2P RN Mcl-1 inhibitors: a patent review.Expert Opin Ther Pat. 2017 Feb;27(2):163-178. DMFKS2P RU https://www.ncbi.nlm.nih.gov/pubmed/27744724 DMFKS2P DI DMFKS2P DMFKS2P DN PMID27744724-Compound-10 DMFKS2P MI TTU1E82 DMFKS2P MN Apoptosis regulator Bcl-xL (BCL-xL) DMFKS2P MT DTT DMFKS2P MA Inhibitor DMFKS2P RN Mcl-1 inhibitors: a patent review.Expert Opin Ther Pat. 2017 Feb;27(2):163-178. DMFKS2P RU https://www.ncbi.nlm.nih.gov/pubmed/27744724 DMFKS2P DI DMFKS2P DMFKS2P DN PMID27744724-Compound-10 DMFKS2P MI TTL53M6 DMFKS2P MN Induced myeloid leukemia cell differentiation protein Mcl-1 (MCL1) DMFKS2P MT DTT DMFKS2P MA Inhibitor DMFKS2P RN Mcl-1 inhibitors: a patent review.Expert Opin Ther Pat. 2017 Feb;27(2):163-178. DMFKS2P RU https://www.ncbi.nlm.nih.gov/pubmed/27744724 DMCFOXP DI DMCFOXP DMCFOXP DN PMID27744724-Compound-13 DMCFOXP MI TTL53M6 DMCFOXP MN Induced myeloid leukemia cell differentiation protein Mcl-1 (MCL1) DMCFOXP MT DTT DMCFOXP MA Inhibitor DMCFOXP RN Mcl-1 inhibitors: a patent review.Expert Opin Ther Pat. 2017 Feb;27(2):163-178. DMCFOXP RU https://www.ncbi.nlm.nih.gov/pubmed/27744724 DM73S2C DI DM73S2C DM73S2C DN PMID27744724-Compound-18 DM73S2C MI TTJGNVC DM73S2C MN Apoptosis regulator Bcl-2 (BCL-2) DM73S2C MT DTT DM73S2C MA Inhibitor DM73S2C RN Mcl-1 inhibitors: a patent review.Expert Opin Ther Pat. 2017 Feb;27(2):163-178. DM73S2C RU https://www.ncbi.nlm.nih.gov/pubmed/27744724 DM73S2C DI DM73S2C DM73S2C DN PMID27744724-Compound-18 DM73S2C MI TTQ79W8 DM73S2C MN Apoptosis regulator Bcl-W (BCL-W) DM73S2C MT DTT DM73S2C MA Inhibitor DM73S2C RN Mcl-1 inhibitors: a patent review.Expert Opin Ther Pat. 2017 Feb;27(2):163-178. DM73S2C RU https://www.ncbi.nlm.nih.gov/pubmed/27744724 DM73S2C DI DM73S2C DM73S2C DN PMID27744724-Compound-18 DM73S2C MI TTU1E82 DM73S2C MN Apoptosis regulator Bcl-xL (BCL-xL) DM73S2C MT DTT DM73S2C MA Inhibitor DM73S2C RN Mcl-1 inhibitors: a patent review.Expert Opin Ther Pat. 2017 Feb;27(2):163-178. DM73S2C RU https://www.ncbi.nlm.nih.gov/pubmed/27744724 DM73S2C DI DM73S2C DM73S2C DN PMID27744724-Compound-18 DM73S2C MI TTL53M6 DM73S2C MN Induced myeloid leukemia cell differentiation protein Mcl-1 (MCL1) DM73S2C MT DTT DM73S2C MA Inhibitor DM73S2C RN Mcl-1 inhibitors: a patent review.Expert Opin Ther Pat. 2017 Feb;27(2):163-178. DM73S2C RU https://www.ncbi.nlm.nih.gov/pubmed/27744724 DM214WA DI DM214WA DM214WA DN PMID27744724-Compound-19 DM214WA MI TTL53M6 DM214WA MN Induced myeloid leukemia cell differentiation protein Mcl-1 (MCL1) DM214WA MT DTT DM214WA MA Inhibitor DM214WA RN Mcl-1 inhibitors: a patent review.Expert Opin Ther Pat. 2017 Feb;27(2):163-178. DM214WA RU https://www.ncbi.nlm.nih.gov/pubmed/27744724 DMD0T6S DI DMD0T6S DMD0T6S DN PMID27744724-Compound-20 DMD0T6S MI TTL53M6 DMD0T6S MN Induced myeloid leukemia cell differentiation protein Mcl-1 (MCL1) DMD0T6S MT DTT DMD0T6S MA Inhibitor DMD0T6S RN Mcl-1 inhibitors: a patent review.Expert Opin Ther Pat. 2017 Feb;27(2):163-178. DMD0T6S RU https://www.ncbi.nlm.nih.gov/pubmed/27744724 DM18UA5 DI DM18UA5 DM18UA5 DN PMID27744724-Compound-21 DM18UA5 MI TTJGNVC DM18UA5 MN Apoptosis regulator Bcl-2 (BCL-2) DM18UA5 MT DTT DM18UA5 MA Inhibitor DM18UA5 RN Mcl-1 inhibitors: a patent review.Expert Opin Ther Pat. 2017 Feb;27(2):163-178. DM18UA5 RU https://www.ncbi.nlm.nih.gov/pubmed/27744724 DM18UA5 DI DM18UA5 DM18UA5 DN PMID27744724-Compound-21 DM18UA5 MI TTU1E82 DM18UA5 MN Apoptosis regulator Bcl-xL (BCL-xL) DM18UA5 MT DTT DM18UA5 MA Inhibitor DM18UA5 RN Mcl-1 inhibitors: a patent review.Expert Opin Ther Pat. 2017 Feb;27(2):163-178. DM18UA5 RU https://www.ncbi.nlm.nih.gov/pubmed/27744724 DM18UA5 DI DM18UA5 DM18UA5 DN PMID27744724-Compound-21 DM18UA5 MI TTL53M6 DM18UA5 MN Induced myeloid leukemia cell differentiation protein Mcl-1 (MCL1) DM18UA5 MT DTT DM18UA5 MA Inhibitor DM18UA5 RN Mcl-1 inhibitors: a patent review.Expert Opin Ther Pat. 2017 Feb;27(2):163-178. DM18UA5 RU https://www.ncbi.nlm.nih.gov/pubmed/27744724 DMM6FOW DI DMM6FOW DMM6FOW DN PMID27744724-Compound-22 DMM6FOW MI TTL53M6 DMM6FOW MN Induced myeloid leukemia cell differentiation protein Mcl-1 (MCL1) DMM6FOW MT DTT DMM6FOW MA Inhibitor DMM6FOW RN Mcl-1 inhibitors: a patent review.Expert Opin Ther Pat. 2017 Feb;27(2):163-178. DMM6FOW RU https://www.ncbi.nlm.nih.gov/pubmed/27744724 DMXA70C DI DMXA70C DMXA70C DN PMID27744724-Compound-23 DMXA70C MI TTL53M6 DMXA70C MN Induced myeloid leukemia cell differentiation protein Mcl-1 (MCL1) DMXA70C MT DTT DMXA70C MA Inhibitor DMXA70C RN Mcl-1 inhibitors: a patent review.Expert Opin Ther Pat. 2017 Feb;27(2):163-178. DMXA70C RU https://www.ncbi.nlm.nih.gov/pubmed/27744724 DM8GOH3 DI DM8GOH3 DM8GOH3 DN PMID27744724-Compound-26 DM8GOH3 MI TTU1E82 DM8GOH3 MN Apoptosis regulator Bcl-xL (BCL-xL) DM8GOH3 MT DTT DM8GOH3 MA Inhibitor DM8GOH3 RN Mcl-1 inhibitors: a patent review.Expert Opin Ther Pat. 2017 Feb;27(2):163-178. DM8GOH3 RU https://www.ncbi.nlm.nih.gov/pubmed/27744724 DM8GOH3 DI DM8GOH3 DM8GOH3 DN PMID27744724-Compound-26 DM8GOH3 MI TTL53M6 DM8GOH3 MN Induced myeloid leukemia cell differentiation protein Mcl-1 (MCL1) DM8GOH3 MT DTT DM8GOH3 MA Inhibitor DM8GOH3 RN Mcl-1 inhibitors: a patent review.Expert Opin Ther Pat. 2017 Feb;27(2):163-178. DM8GOH3 RU https://www.ncbi.nlm.nih.gov/pubmed/27744724 DMV6MLC DI DMV6MLC DMV6MLC DN PMID27744724-Compound-27 DMV6MLC MI TTU1E82 DMV6MLC MN Apoptosis regulator Bcl-xL (BCL-xL) DMV6MLC MT DTT DMV6MLC MA Inhibitor DMV6MLC RN Mcl-1 inhibitors: a patent review.Expert Opin Ther Pat. 2017 Feb;27(2):163-178. DMV6MLC RU https://www.ncbi.nlm.nih.gov/pubmed/27744724 DMV6MLC DI DMV6MLC DMV6MLC DN PMID27744724-Compound-27 DMV6MLC MI TTL53M6 DMV6MLC MN Induced myeloid leukemia cell differentiation protein Mcl-1 (MCL1) DMV6MLC MT DTT DMV6MLC MA Inhibitor DMV6MLC RN Mcl-1 inhibitors: a patent review.Expert Opin Ther Pat. 2017 Feb;27(2):163-178. DMV6MLC RU https://www.ncbi.nlm.nih.gov/pubmed/27744724 DMB018S DI DMB018S DMB018S DN PMID27744724-Compound-28 DMB018S MI TTL53M6 DMB018S MN Induced myeloid leukemia cell differentiation protein Mcl-1 (MCL1) DMB018S MT DTT DMB018S MA Inhibitor DMB018S RN Mcl-1 inhibitors: a patent review.Expert Opin Ther Pat. 2017 Feb;27(2):163-178. DMB018S RU https://www.ncbi.nlm.nih.gov/pubmed/27744724 DM2GDXH DI DM2GDXH DM2GDXH DN PMID27744724-Compound-29 DM2GDXH MI TTL53M6 DM2GDXH MN Induced myeloid leukemia cell differentiation protein Mcl-1 (MCL1) DM2GDXH MT DTT DM2GDXH MA Inhibitor DM2GDXH RN Mcl-1 inhibitors: a patent review.Expert Opin Ther Pat. 2017 Feb;27(2):163-178. DM2GDXH RU https://www.ncbi.nlm.nih.gov/pubmed/27744724 DMWKYU4 DI DMWKYU4 DMWKYU4 DN PMID27744724-Compound-3 DMWKYU4 MI TTL53M6 DMWKYU4 MN Induced myeloid leukemia cell differentiation protein Mcl-1 (MCL1) DMWKYU4 MT DTT DMWKYU4 MA Inhibitor DMWKYU4 RN Mcl-1 inhibitors: a patent review.Expert Opin Ther Pat. 2017 Feb;27(2):163-178. DMWKYU4 RU https://www.ncbi.nlm.nih.gov/pubmed/27744724 DMV1WND DI DMV1WND DMV1WND DN PMID27744724-Compound-4 DMV1WND MI TTL53M6 DMV1WND MN Induced myeloid leukemia cell differentiation protein Mcl-1 (MCL1) DMV1WND MT DTT DMV1WND MA Inhibitor DMV1WND RN Mcl-1 inhibitors: a patent review.Expert Opin Ther Pat. 2017 Feb;27(2):163-178. DMV1WND RU https://www.ncbi.nlm.nih.gov/pubmed/27744724 DM6UTAQ DI DM6UTAQ DM6UTAQ DN PMID27744724-Compound-5 DM6UTAQ MI TTL53M6 DM6UTAQ MN Induced myeloid leukemia cell differentiation protein Mcl-1 (MCL1) DM6UTAQ MT DTT DM6UTAQ MA Inhibitor DM6UTAQ RN Mcl-1 inhibitors: a patent review.Expert Opin Ther Pat. 2017 Feb;27(2):163-178. DM6UTAQ RU https://www.ncbi.nlm.nih.gov/pubmed/27744724 DMV7P4N DI DMV7P4N DMV7P4N DN PMID27744724-Compound-6 DMV7P4N MI TTL53M6 DMV7P4N MN Induced myeloid leukemia cell differentiation protein Mcl-1 (MCL1) DMV7P4N MT DTT DMV7P4N MA Inhibitor DMV7P4N RN Mcl-1 inhibitors: a patent review.Expert Opin Ther Pat. 2017 Feb;27(2):163-178. DMV7P4N RU https://www.ncbi.nlm.nih.gov/pubmed/27744724 DMT2W97 DI DMT2W97 DMT2W97 DN PMID27744724-Compound-Fomula2 DMT2W97 MI TTL53M6 DMT2W97 MN Induced myeloid leukemia cell differentiation protein Mcl-1 (MCL1) DMT2W97 MT DTT DMT2W97 MA Inhibitor DMT2W97 RN Mcl-1 inhibitors: a patent review.Expert Opin Ther Pat. 2017 Feb;27(2):163-178. DMT2W97 RU https://www.ncbi.nlm.nih.gov/pubmed/27744724 DMFAGOZ DI DMFAGOZ DMFAGOZ DN PMID27774822-Compound-Figure10Compound12 DMFAGOZ MI TTJNBQA DMFAGOZ MN Activin receptor-like kinase 2 (ALK-2) DMFAGOZ MT DTT DMFAGOZ MA Inhibitor DMFAGOZ RN Inhibitors of JAK-family kinases: an update on the patent literature 2013-2015, part 2.Expert Opin Ther Pat. 2017 Feb;27(2):145-161. DMFAGOZ RU https://www.ncbi.nlm.nih.gov/pubmed/27774822 DMFAGOZ DI DMFAGOZ DMFAGOZ DN PMID27774822-Compound-Figure10Compound12 DMFAGOZ MI TTRMX3V DMFAGOZ MN Janus kinase 2 (JAK-2) DMFAGOZ MT DTT DMFAGOZ MA Inhibitor DMFAGOZ RN Inhibitors of JAK-family kinases: an update on the patent literature 2013-2015, part 2.Expert Opin Ther Pat. 2017 Feb;27(2):145-161. DMFAGOZ RU https://www.ncbi.nlm.nih.gov/pubmed/27774822 DMMJVTW DI DMMJVTW DMMJVTW DN PMID27774822-Compound-Figure10Compound4 DMMJVTW MI TTJNBQA DMMJVTW MN Activin receptor-like kinase 2 (ALK-2) DMMJVTW MT DTT DMMJVTW MA Inhibitor DMMJVTW RN Inhibitors of JAK-family kinases: an update on the patent literature 2013-2015, part 2.Expert Opin Ther Pat. 2017 Feb;27(2):145-161. DMMJVTW RU https://www.ncbi.nlm.nih.gov/pubmed/27774822 DMMJVTW DI DMMJVTW DMMJVTW DN PMID27774822-Compound-Figure10Compound4 DMMJVTW MI TTRMX3V DMMJVTW MN Janus kinase 2 (JAK-2) DMMJVTW MT DTT DMMJVTW MA Inhibitor DMMJVTW RN Inhibitors of JAK-family kinases: an update on the patent literature 2013-2015, part 2.Expert Opin Ther Pat. 2017 Feb;27(2):145-161. DMMJVTW RU https://www.ncbi.nlm.nih.gov/pubmed/27774822 DM3M6SE DI DM3M6SE DM3M6SE DN PMID27774822-Compound-Figure10CompoundA DM3M6SE MI TTJSQEF DM3M6SE MN Tyrosine-protein kinase (PTK) DM3M6SE MT DTT DM3M6SE MA Inhibitor DM3M6SE RN Inhibitors of JAK-family kinases: an update on the patent literature 2013-2015, part 2.Expert Opin Ther Pat. 2017 Feb;27(2):145-161. DM3M6SE RU https://www.ncbi.nlm.nih.gov/pubmed/27774822 DMCTXPQ DI DMCTXPQ DMCTXPQ DN PMID27774822-Compound-Figure10Example1 DMCTXPQ MI TTRMX3V DMCTXPQ MN Janus kinase 2 (JAK-2) DMCTXPQ MT DTT DMCTXPQ MA Inhibitor DMCTXPQ RN Inhibitors of JAK-family kinases: an update on the patent literature 2013-2015, part 2.Expert Opin Ther Pat. 2017 Feb;27(2):145-161. DMCTXPQ RU https://www.ncbi.nlm.nih.gov/pubmed/27774822 DMCTXPQ DI DMCTXPQ DMCTXPQ DN PMID27774822-Compound-Figure10Example1 DMCTXPQ MI TTT7PJU DMCTXPQ MN Janus kinase 3 (JAK-3) DMCTXPQ MT DTT DMCTXPQ MA Inhibitor DMCTXPQ RN Inhibitors of JAK-family kinases: an update on the patent literature 2013-2015, part 2.Expert Opin Ther Pat. 2017 Feb;27(2):145-161. DMCTXPQ RU https://www.ncbi.nlm.nih.gov/pubmed/27774822 DMCTXPQ DI DMCTXPQ DMCTXPQ DN PMID27774822-Compound-Figure10Example1 DMCTXPQ MI TTJSQEF DMCTXPQ MN Tyrosine-protein kinase (PTK) DMCTXPQ MT DTT DMCTXPQ MA Inhibitor DMCTXPQ RN Inhibitors of JAK-family kinases: an update on the patent literature 2013-2015, part 2.Expert Opin Ther Pat. 2017 Feb;27(2):145-161. DMCTXPQ RU https://www.ncbi.nlm.nih.gov/pubmed/27774822 DMNXYZP DI DMNXYZP DMNXYZP DN PMID27774822-Compound-Figure10Example19 DMNXYZP MI TTRMX3V DMNXYZP MN Janus kinase 2 (JAK-2) DMNXYZP MT DTT DMNXYZP MA Inhibitor DMNXYZP RN Inhibitors of JAK-family kinases: an update on the patent literature 2013-2015, part 2.Expert Opin Ther Pat. 2017 Feb;27(2):145-161. DMNXYZP RU https://www.ncbi.nlm.nih.gov/pubmed/27774822 DMNXYZP DI DMNXYZP DMNXYZP DN PMID27774822-Compound-Figure10Example19 DMNXYZP MI TTT7PJU DMNXYZP MN Janus kinase 3 (JAK-3) DMNXYZP MT DTT DMNXYZP MA Inhibitor DMNXYZP RN Inhibitors of JAK-family kinases: an update on the patent literature 2013-2015, part 2.Expert Opin Ther Pat. 2017 Feb;27(2):145-161. DMNXYZP RU https://www.ncbi.nlm.nih.gov/pubmed/27774822 DMAHFXV DI DMAHFXV DMAHFXV DN PMID27774822-Compound-Figure11Example5 DMAHFXV MI TT6DM01 DMAHFXV MN Janus kinase 1 (JAK-1) DMAHFXV MT DTT DMAHFXV MA Inhibitor DMAHFXV RN Inhibitors of JAK-family kinases: an update on the patent literature 2013-2015, part 2.Expert Opin Ther Pat. 2017 Feb;27(2):145-161. DMAHFXV RU https://www.ncbi.nlm.nih.gov/pubmed/27774822 DMAHFXV DI DMAHFXV DMAHFXV DN PMID27774822-Compound-Figure11Example5 DMAHFXV MI TTRMX3V DMAHFXV MN Janus kinase 2 (JAK-2) DMAHFXV MT DTT DMAHFXV MA Inhibitor DMAHFXV RN Inhibitors of JAK-family kinases: an update on the patent literature 2013-2015, part 2.Expert Opin Ther Pat. 2017 Feb;27(2):145-161. DMAHFXV RU https://www.ncbi.nlm.nih.gov/pubmed/27774822 DMAHFXV DI DMAHFXV DMAHFXV DN PMID27774822-Compound-Figure11Example5 DMAHFXV MI TTT7PJU DMAHFXV MN Janus kinase 3 (JAK-3) DMAHFXV MT DTT DMAHFXV MA Inhibitor DMAHFXV RN Inhibitors of JAK-family kinases: an update on the patent literature 2013-2015, part 2.Expert Opin Ther Pat. 2017 Feb;27(2):145-161. DMAHFXV RU https://www.ncbi.nlm.nih.gov/pubmed/27774822 DMAHFXV DI DMAHFXV DMAHFXV DN PMID27774822-Compound-Figure11Example5 DMAHFXV MI TTBYWP2 DMAHFXV MN TYK2 tyrosine kinase (TYK2) DMAHFXV MT DTT DMAHFXV MA Inhibitor DMAHFXV RN Inhibitors of JAK-family kinases: an update on the patent literature 2013-2015, part 2.Expert Opin Ther Pat. 2017 Feb;27(2):145-161. DMAHFXV RU https://www.ncbi.nlm.nih.gov/pubmed/27774822 DMCL19N DI DMCL19N DMCL19N DN PMID27774822-Compound-Figure1Example20 DMCL19N MI TT6DM01 DMCL19N MN Janus kinase 1 (JAK-1) DMCL19N MT DTT DMCL19N MA Inhibitor DMCL19N RN Inhibitors of JAK-family kinases: an update on the patent literature 2013-2015, part 2.Expert Opin Ther Pat. 2017 Feb;27(2):145-161. DMCL19N RU https://www.ncbi.nlm.nih.gov/pubmed/27774822 DMCL19N DI DMCL19N DMCL19N DN PMID27774822-Compound-Figure1Example20 DMCL19N MI TTRMX3V DMCL19N MN Janus kinase 2 (JAK-2) DMCL19N MT DTT DMCL19N MA Inhibitor DMCL19N RN Inhibitors of JAK-family kinases: an update on the patent literature 2013-2015, part 2.Expert Opin Ther Pat. 2017 Feb;27(2):145-161. DMCL19N RU https://www.ncbi.nlm.nih.gov/pubmed/27774822 DMCL19N DI DMCL19N DMCL19N DN PMID27774822-Compound-Figure1Example20 DMCL19N MI TTT7PJU DMCL19N MN Janus kinase 3 (JAK-3) DMCL19N MT DTT DMCL19N MA Inhibitor DMCL19N RN Inhibitors of JAK-family kinases: an update on the patent literature 2013-2015, part 2.Expert Opin Ther Pat. 2017 Feb;27(2):145-161. DMCL19N RU https://www.ncbi.nlm.nih.gov/pubmed/27774822 DM86M7D DI DM86M7D DM86M7D DN PMID27774822-Compound-Figure2Example1-1left DM86M7D MI TTRMX3V DM86M7D MN Janus kinase 2 (JAK-2) DM86M7D MT DTT DM86M7D MA Inhibitor DM86M7D RN Inhibitors of JAK-family kinases: an update on the patent literature 2013-2015, part 2.Expert Opin Ther Pat. 2017 Feb;27(2):145-161. DM86M7D RU https://www.ncbi.nlm.nih.gov/pubmed/27774822 DM86M7D DI DM86M7D DM86M7D DN PMID27774822-Compound-Figure2Example1-1left DM86M7D MI TTT7PJU DM86M7D MN Janus kinase 3 (JAK-3) DM86M7D MT DTT DM86M7D MA Inhibitor DM86M7D RN Inhibitors of JAK-family kinases: an update on the patent literature 2013-2015, part 2.Expert Opin Ther Pat. 2017 Feb;27(2):145-161. DM86M7D RU https://www.ncbi.nlm.nih.gov/pubmed/27774822 DM2YPLF DI DM2YPLF DM2YPLF DN PMID27774822-Compound-Figure2Example1-1right DM2YPLF MI TTRMX3V DM2YPLF MN Janus kinase 2 (JAK-2) DM2YPLF MT DTT DM2YPLF MA Inhibitor DM2YPLF RN Inhibitors of JAK-family kinases: an update on the patent literature 2013-2015, part 2.Expert Opin Ther Pat. 2017 Feb;27(2):145-161. DM2YPLF RU https://www.ncbi.nlm.nih.gov/pubmed/27774822 DM2YPLF DI DM2YPLF DM2YPLF DN PMID27774822-Compound-Figure2Example1-1right DM2YPLF MI TTT7PJU DM2YPLF MN Janus kinase 3 (JAK-3) DM2YPLF MT DTT DM2YPLF MA Inhibitor DM2YPLF RN Inhibitors of JAK-family kinases: an update on the patent literature 2013-2015, part 2.Expert Opin Ther Pat. 2017 Feb;27(2):145-161. DM2YPLF RU https://www.ncbi.nlm.nih.gov/pubmed/27774822 DMEHIS4 DI DMEHIS4 DMEHIS4 DN PMID27774822-Compound-Figure2Example4-3 DMEHIS4 MI TTT7PJU DMEHIS4 MN Janus kinase 3 (JAK-3) DMEHIS4 MT DTT DMEHIS4 MA Inhibitor DMEHIS4 RN Inhibitors of JAK-family kinases: an update on the patent literature 2013-2015, part 2.Expert Opin Ther Pat. 2017 Feb;27(2):145-161. DMEHIS4 RU https://www.ncbi.nlm.nih.gov/pubmed/27774822 DMOENP4 DI DMOENP4 DMOENP4 DN PMID27774822-Compound-Figure3CompoundI-165 DMOENP4 MI TTRMX3V DMOENP4 MN Janus kinase 2 (JAK-2) DMOENP4 MT DTT DMOENP4 MA Inhibitor DMOENP4 RN Inhibitors of JAK-family kinases: an update on the patent literature 2013-2015, part 2.Expert Opin Ther Pat. 2017 Feb;27(2):145-161. DMOENP4 RU https://www.ncbi.nlm.nih.gov/pubmed/27774822 DMOENP4 DI DMOENP4 DMOENP4 DN PMID27774822-Compound-Figure3CompoundI-165 DMOENP4 MI TTBYWP2 DMOENP4 MN TYK2 tyrosine kinase (TYK2) DMOENP4 MT DTT DMOENP4 MA Inhibitor DMOENP4 RN Inhibitors of JAK-family kinases: an update on the patent literature 2013-2015, part 2.Expert Opin Ther Pat. 2017 Feb;27(2):145-161. DMOENP4 RU https://www.ncbi.nlm.nih.gov/pubmed/27774822 DMCD19T DI DMCD19T DMCD19T DN PMID27774822-Compound-Figure6Example2 DMCD19T MI TTT7PJU DMCD19T MN Janus kinase 3 (JAK-3) DMCD19T MT DTT DMCD19T MA Inhibitor DMCD19T RN Inhibitors of JAK-family kinases: an update on the patent literature 2013-2015, part 2.Expert Opin Ther Pat. 2017 Feb;27(2):145-161. DMCD19T RU https://www.ncbi.nlm.nih.gov/pubmed/27774822 DM3FY85 DI DM3FY85 DM3FY85 DN PMID27774822-Compound-Figure6Example3 DM3FY85 MI TTT7PJU DM3FY85 MN Janus kinase 3 (JAK-3) DM3FY85 MT DTT DM3FY85 MA Inhibitor DM3FY85 RN Inhibitors of JAK-family kinases: an update on the patent literature 2013-2015, part 2.Expert Opin Ther Pat. 2017 Feb;27(2):145-161. DM3FY85 RU https://www.ncbi.nlm.nih.gov/pubmed/27774822 DMF5IWB DI DMF5IWB DMF5IWB DN PMID27774822-Compound-Figure7Example63 DMF5IWB MI TT6DM01 DMF5IWB MN Janus kinase 1 (JAK-1) DMF5IWB MT DTT DMF5IWB MA Inhibitor DMF5IWB RN Inhibitors of JAK-family kinases: an update on the patent literature 2013-2015, part 2.Expert Opin Ther Pat. 2017 Feb;27(2):145-161. DMF5IWB RU https://www.ncbi.nlm.nih.gov/pubmed/27774822 DMF5IWB DI DMF5IWB DMF5IWB DN PMID27774822-Compound-Figure7Example63 DMF5IWB MI TTRMX3V DMF5IWB MN Janus kinase 2 (JAK-2) DMF5IWB MT DTT DMF5IWB MA Inhibitor DMF5IWB RN Inhibitors of JAK-family kinases: an update on the patent literature 2013-2015, part 2.Expert Opin Ther Pat. 2017 Feb;27(2):145-161. DMF5IWB RU https://www.ncbi.nlm.nih.gov/pubmed/27774822 DMRHZF3 DI DMRHZF3 DMRHZF3 DN PMID27774822-Compound-Figure8Example5 DMRHZF3 MI TTRMX3V DMRHZF3 MN Janus kinase 2 (JAK-2) DMRHZF3 MT DTT DMRHZF3 MA Inhibitor DMRHZF3 RN Inhibitors of JAK-family kinases: an update on the patent literature 2013-2015, part 2.Expert Opin Ther Pat. 2017 Feb;27(2):145-161. DMRHZF3 RU https://www.ncbi.nlm.nih.gov/pubmed/27774822 DMRHZF3 DI DMRHZF3 DMRHZF3 DN PMID27774822-Compound-Figure8Example5 DMRHZF3 MI TTT7PJU DMRHZF3 MN Janus kinase 3 (JAK-3) DMRHZF3 MT DTT DMRHZF3 MA Inhibitor DMRHZF3 RN Inhibitors of JAK-family kinases: an update on the patent literature 2013-2015, part 2.Expert Opin Ther Pat. 2017 Feb;27(2):145-161. DMRHZF3 RU https://www.ncbi.nlm.nih.gov/pubmed/27774822 DMSHIT2 DI DMSHIT2 DMSHIT2 DN PMID27774822-Compound-Figure9Example15 DMSHIT2 MI TTBYWP2 DMSHIT2 MN TYK2 tyrosine kinase (TYK2) DMSHIT2 MT DTT DMSHIT2 MA Inhibitor DMSHIT2 RN Inhibitors of JAK-family kinases: an update on the patent literature 2013-2015, part 2.Expert Opin Ther Pat. 2017 Feb;27(2):145-161. DMSHIT2 RU https://www.ncbi.nlm.nih.gov/pubmed/27774822 DMH1W8F DI DMH1W8F DMH1W8F DN PMID27774824-Compound-Figure11Example1up DMH1W8F MI TTKAWRQ DMH1W8F MN JAK-STAT signaling pathway (JAK-STAT pathway) DMH1W8F MT DTT DMH1W8F MA Inhibitor DMH1W8F RN Inhibitors of JAK-family kinases: an update on the patent literature 2013-2015, part 1.Expert Opin Ther Pat. 2017 Feb;27(2):127-143. DMH1W8F RU https://www.ncbi.nlm.nih.gov/pubmed/27774824 DMH1W8F DI DMH1W8F DMH1W8F DN PMID27774824-Compound-Figure11Example1up DMH1W8F MI TT6DM01 DMH1W8F MN Janus kinase 1 (JAK-1) DMH1W8F MT DTT DMH1W8F MA Inhibitor DMH1W8F RN Inhibitors of JAK-family kinases: an update on the patent literature 2013-2015, part 1.Expert Opin Ther Pat. 2017 Feb;27(2):127-143. DMH1W8F RU https://www.ncbi.nlm.nih.gov/pubmed/27774824 DMH1W8F DI DMH1W8F DMH1W8F DN PMID27774824-Compound-Figure11Example1up DMH1W8F MI TTRMX3V DMH1W8F MN Janus kinase 2 (JAK-2) DMH1W8F MT DTT DMH1W8F MA Inhibitor DMH1W8F RN Inhibitors of JAK-family kinases: an update on the patent literature 2013-2015, part 1.Expert Opin Ther Pat. 2017 Feb;27(2):127-143. DMH1W8F RU https://www.ncbi.nlm.nih.gov/pubmed/27774824 DMH1W8F DI DMH1W8F DMH1W8F DN PMID27774824-Compound-Figure11Example1up DMH1W8F MI TTT7PJU DMH1W8F MN Janus kinase 3 (JAK-3) DMH1W8F MT DTT DMH1W8F MA Inhibitor DMH1W8F RN Inhibitors of JAK-family kinases: an update on the patent literature 2013-2015, part 1.Expert Opin Ther Pat. 2017 Feb;27(2):127-143. DMH1W8F RU https://www.ncbi.nlm.nih.gov/pubmed/27774824 DMH1W8F DI DMH1W8F DMH1W8F DN PMID27774824-Compound-Figure11Example1up DMH1W8F MI TTBYWP2 DMH1W8F MN TYK2 tyrosine kinase (TYK2) DMH1W8F MT DTT DMH1W8F MA Inhibitor DMH1W8F RN Inhibitors of JAK-family kinases: an update on the patent literature 2013-2015, part 1.Expert Opin Ther Pat. 2017 Feb;27(2):127-143. DMH1W8F RU https://www.ncbi.nlm.nih.gov/pubmed/27774824 DMH1W8F DI DMH1W8F DMH1W8F DN PMID27774824-Compound-Figure11Example1up DMH1W8F MI TTJSQEF DMH1W8F MN Tyrosine-protein kinase (PTK) DMH1W8F MT DTT DMH1W8F MA Inhibitor DMH1W8F RN Inhibitors of JAK-family kinases: an update on the patent literature 2013-2015, part 1.Expert Opin Ther Pat. 2017 Feb;27(2):127-143. DMH1W8F RU https://www.ncbi.nlm.nih.gov/pubmed/27774824 DMAGKNJ DI DMAGKNJ DMAGKNJ DN PMID27774824-Compound-Figure12Example1 DMAGKNJ MI TTT7PJU DMAGKNJ MN Janus kinase 3 (JAK-3) DMAGKNJ MT DTT DMAGKNJ MA Inhibitor DMAGKNJ RN Inhibitors of JAK-family kinases: an update on the patent literature 2013-2015, part 1.Expert Opin Ther Pat. 2017 Feb;27(2):127-143. DMAGKNJ RU https://www.ncbi.nlm.nih.gov/pubmed/27774824 DMAGKNJ DI DMAGKNJ DMAGKNJ DN PMID27774824-Compound-Figure12Example1 DMAGKNJ MI TTGM6VW DMAGKNJ MN Tyrosine-protein kinase BTK (ATK) DMAGKNJ MT DTT DMAGKNJ MA Inhibitor DMAGKNJ RN Inhibitors of JAK-family kinases: an update on the patent literature 2013-2015, part 1.Expert Opin Ther Pat. 2017 Feb;27(2):127-143. DMAGKNJ RU https://www.ncbi.nlm.nih.gov/pubmed/27774824 DMYOSIA DI DMYOSIA DMYOSIA DN PMID27774824-Compound-Figure12Example10 DMYOSIA MI TTT7PJU DMYOSIA MN Janus kinase 3 (JAK-3) DMYOSIA MT DTT DMYOSIA MA Inhibitor DMYOSIA RN Inhibitors of JAK-family kinases: an update on the patent literature 2013-2015, part 1.Expert Opin Ther Pat. 2017 Feb;27(2):127-143. DMYOSIA RU https://www.ncbi.nlm.nih.gov/pubmed/27774824 DMYOSIA DI DMYOSIA DMYOSIA DN PMID27774824-Compound-Figure12Example10 DMYOSIA MI TTGM6VW DMYOSIA MN Tyrosine-protein kinase BTK (ATK) DMYOSIA MT DTT DMYOSIA MA Inhibitor DMYOSIA RN Inhibitors of JAK-family kinases: an update on the patent literature 2013-2015, part 1.Expert Opin Ther Pat. 2017 Feb;27(2):127-143. DMYOSIA RU https://www.ncbi.nlm.nih.gov/pubmed/27774824 DMNIZD7 DI DMNIZD7 DMNIZD7 DN PMID27774824-Compound-Figure12Example61 DMNIZD7 MI TTT7PJU DMNIZD7 MN Janus kinase 3 (JAK-3) DMNIZD7 MT DTT DMNIZD7 MA Inhibitor DMNIZD7 RN Inhibitors of JAK-family kinases: an update on the patent literature 2013-2015, part 1.Expert Opin Ther Pat. 2017 Feb;27(2):127-143. DMNIZD7 RU https://www.ncbi.nlm.nih.gov/pubmed/27774824 DMNIZD7 DI DMNIZD7 DMNIZD7 DN PMID27774824-Compound-Figure12Example61 DMNIZD7 MI TTGM6VW DMNIZD7 MN Tyrosine-protein kinase BTK (ATK) DMNIZD7 MT DTT DMNIZD7 MA Inhibitor DMNIZD7 RN Inhibitors of JAK-family kinases: an update on the patent literature 2013-2015, part 1.Expert Opin Ther Pat. 2017 Feb;27(2):127-143. DMNIZD7 RU https://www.ncbi.nlm.nih.gov/pubmed/27774824 DMQHYMJ DI DMQHYMJ DMQHYMJ DN PMID27774824-Compound-Figure2Example4 DMQHYMJ MI TT6DM01 DMQHYMJ MN Janus kinase 1 (JAK-1) DMQHYMJ MT DTT DMQHYMJ MA Inhibitor DMQHYMJ RN Inhibitors of JAK-family kinases: an update on the patent literature 2013-2015, part 1.Expert Opin Ther Pat. 2017 Feb;27(2):127-143. DMQHYMJ RU https://www.ncbi.nlm.nih.gov/pubmed/27774824 DMQHYMJ DI DMQHYMJ DMQHYMJ DN PMID27774824-Compound-Figure2Example4 DMQHYMJ MI TTRMX3V DMQHYMJ MN Janus kinase 2 (JAK-2) DMQHYMJ MT DTT DMQHYMJ MA Inhibitor DMQHYMJ RN Inhibitors of JAK-family kinases: an update on the patent literature 2013-2015, part 1.Expert Opin Ther Pat. 2017 Feb;27(2):127-143. DMQHYMJ RU https://www.ncbi.nlm.nih.gov/pubmed/27774824 DMQHYMJ DI DMQHYMJ DMQHYMJ DN PMID27774824-Compound-Figure2Example4 DMQHYMJ MI TTT7PJU DMQHYMJ MN Janus kinase 3 (JAK-3) DMQHYMJ MT DTT DMQHYMJ MA Inhibitor DMQHYMJ RN Inhibitors of JAK-family kinases: an update on the patent literature 2013-2015, part 1.Expert Opin Ther Pat. 2017 Feb;27(2):127-143. DMQHYMJ RU https://www.ncbi.nlm.nih.gov/pubmed/27774824 DMYZ6XQ DI DMYZ6XQ DMYZ6XQ DN PMID27774824-Compound-Figure3Example18 DMYZ6XQ MI TT6DM01 DMYZ6XQ MN Janus kinase 1 (JAK-1) DMYZ6XQ MT DTT DMYZ6XQ MA Inhibitor DMYZ6XQ RN Inhibitors of JAK-family kinases: an update on the patent literature 2013-2015, part 1.Expert Opin Ther Pat. 2017 Feb;27(2):127-143. DMYZ6XQ RU https://www.ncbi.nlm.nih.gov/pubmed/27774824 DMYZ6XQ DI DMYZ6XQ DMYZ6XQ DN PMID27774824-Compound-Figure3Example18 DMYZ6XQ MI TTRMX3V DMYZ6XQ MN Janus kinase 2 (JAK-2) DMYZ6XQ MT DTT DMYZ6XQ MA Inhibitor DMYZ6XQ RN Inhibitors of JAK-family kinases: an update on the patent literature 2013-2015, part 1.Expert Opin Ther Pat. 2017 Feb;27(2):127-143. DMYZ6XQ RU https://www.ncbi.nlm.nih.gov/pubmed/27774824 DMYZ6XQ DI DMYZ6XQ DMYZ6XQ DN PMID27774824-Compound-Figure3Example18 DMYZ6XQ MI TTT7PJU DMYZ6XQ MN Janus kinase 3 (JAK-3) DMYZ6XQ MT DTT DMYZ6XQ MA Inhibitor DMYZ6XQ RN Inhibitors of JAK-family kinases: an update on the patent literature 2013-2015, part 1.Expert Opin Ther Pat. 2017 Feb;27(2):127-143. DMYZ6XQ RU https://www.ncbi.nlm.nih.gov/pubmed/27774824 DMYZ6XQ DI DMYZ6XQ DMYZ6XQ DN PMID27774824-Compound-Figure3Example18 DMYZ6XQ MI TTBYWP2 DMYZ6XQ MN TYK2 tyrosine kinase (TYK2) DMYZ6XQ MT DTT DMYZ6XQ MA Inhibitor DMYZ6XQ RN Inhibitors of JAK-family kinases: an update on the patent literature 2013-2015, part 1.Expert Opin Ther Pat. 2017 Feb;27(2):127-143. DMYZ6XQ RU https://www.ncbi.nlm.nih.gov/pubmed/27774824 DMXDOGK DI DMXDOGK DMXDOGK DN PMID27774824-Compound-Figure3Example7 DMXDOGK MI TTT7PJU DMXDOGK MN Janus kinase 3 (JAK-3) DMXDOGK MT DTT DMXDOGK MA Inhibitor DMXDOGK RN Inhibitors of JAK-family kinases: an update on the patent literature 2013-2015, part 1.Expert Opin Ther Pat. 2017 Feb;27(2):127-143. DMXDOGK RU https://www.ncbi.nlm.nih.gov/pubmed/27774824 DMXDOGK DI DMXDOGK DMXDOGK DN PMID27774824-Compound-Figure3Example7 DMXDOGK MI TT3C80U DMXDOGK MN T-cell-specific kinase (ITK) DMXDOGK MT DTT DMXDOGK MA Inhibitor DMXDOGK RN Inhibitors of JAK-family kinases: an update on the patent literature 2013-2015, part 1.Expert Opin Ther Pat. 2017 Feb;27(2):127-143. DMXDOGK RU https://www.ncbi.nlm.nih.gov/pubmed/27774824 DMDZKXC DI DMDZKXC DMDZKXC DN PMID27774824-Compound-Figure5Example13 DMDZKXC MI TTT7PJU DMDZKXC MN Janus kinase 3 (JAK-3) DMDZKXC MT DTT DMDZKXC MA Inhibitor DMDZKXC RN Inhibitors of JAK-family kinases: an update on the patent literature 2013-2015, part 1.Expert Opin Ther Pat. 2017 Feb;27(2):127-143. DMDZKXC RU https://www.ncbi.nlm.nih.gov/pubmed/27774824 DM1CM7S DI DM1CM7S DM1CM7S DN PMID27774824-Compound-Figure6Example12 DM1CM7S MI TT6DM01 DM1CM7S MN Janus kinase 1 (JAK-1) DM1CM7S MT DTT DM1CM7S MA Inhibitor DM1CM7S RN Inhibitors of JAK-family kinases: an update on the patent literature 2013-2015, part 1.Expert Opin Ther Pat. 2017 Feb;27(2):127-143. DM1CM7S RU https://www.ncbi.nlm.nih.gov/pubmed/27774824 DM1CM7S DI DM1CM7S DM1CM7S DN PMID27774824-Compound-Figure6Example12 DM1CM7S MI TTRMX3V DM1CM7S MN Janus kinase 2 (JAK-2) DM1CM7S MT DTT DM1CM7S MA Inhibitor DM1CM7S RN Inhibitors of JAK-family kinases: an update on the patent literature 2013-2015, part 1.Expert Opin Ther Pat. 2017 Feb;27(2):127-143. DM1CM7S RU https://www.ncbi.nlm.nih.gov/pubmed/27774824 DM1CM7S DI DM1CM7S DM1CM7S DN PMID27774824-Compound-Figure6Example12 DM1CM7S MI TTT7PJU DM1CM7S MN Janus kinase 3 (JAK-3) DM1CM7S MT DTT DM1CM7S MA Inhibitor DM1CM7S RN Inhibitors of JAK-family kinases: an update on the patent literature 2013-2015, part 1.Expert Opin Ther Pat. 2017 Feb;27(2):127-143. DM1CM7S RU https://www.ncbi.nlm.nih.gov/pubmed/27774824 DM1CM7S DI DM1CM7S DM1CM7S DN PMID27774824-Compound-Figure6Example12 DM1CM7S MI TTBYWP2 DM1CM7S MN TYK2 tyrosine kinase (TYK2) DM1CM7S MT DTT DM1CM7S MA Inhibitor DM1CM7S RN Inhibitors of JAK-family kinases: an update on the patent literature 2013-2015, part 1.Expert Opin Ther Pat. 2017 Feb;27(2):127-143. DM1CM7S RU https://www.ncbi.nlm.nih.gov/pubmed/27774824 DMB18V5 DI DMB18V5 DMB18V5 DN PMID27774824-Compound-Figure6Example6 DMB18V5 MI TT6DM01 DMB18V5 MN Janus kinase 1 (JAK-1) DMB18V5 MT DTT DMB18V5 MA Inhibitor DMB18V5 RN Inhibitors of JAK-family kinases: an update on the patent literature 2013-2015, part 1.Expert Opin Ther Pat. 2017 Feb;27(2):127-143. DMB18V5 RU https://www.ncbi.nlm.nih.gov/pubmed/27774824 DMB18V5 DI DMB18V5 DMB18V5 DN PMID27774824-Compound-Figure6Example6 DMB18V5 MI TTRMX3V DMB18V5 MN Janus kinase 2 (JAK-2) DMB18V5 MT DTT DMB18V5 MA Inhibitor DMB18V5 RN Inhibitors of JAK-family kinases: an update on the patent literature 2013-2015, part 1.Expert Opin Ther Pat. 2017 Feb;27(2):127-143. DMB18V5 RU https://www.ncbi.nlm.nih.gov/pubmed/27774824 DMT85AH DI DMT85AH DMT85AH DN PMID27774824-Compound-Figure7Example10 DMT85AH MI TT6DM01 DMT85AH MN Janus kinase 1 (JAK-1) DMT85AH MT DTT DMT85AH MA Inhibitor DMT85AH RN Inhibitors of JAK-family kinases: an update on the patent literature 2013-2015, part 1.Expert Opin Ther Pat. 2017 Feb;27(2):127-143. DMT85AH RU https://www.ncbi.nlm.nih.gov/pubmed/27774824 DMT85AH DI DMT85AH DMT85AH DN PMID27774824-Compound-Figure7Example10 DMT85AH MI TTRMX3V DMT85AH MN Janus kinase 2 (JAK-2) DMT85AH MT DTT DMT85AH MA Inhibitor DMT85AH RN Inhibitors of JAK-family kinases: an update on the patent literature 2013-2015, part 1.Expert Opin Ther Pat. 2017 Feb;27(2):127-143. DMT85AH RU https://www.ncbi.nlm.nih.gov/pubmed/27774824 DM6OCSJ DI DM6OCSJ DM6OCSJ DN PMID27774824-Compound-Figure8Example22 DM6OCSJ MI TTRMX3V DM6OCSJ MN Janus kinase 2 (JAK-2) DM6OCSJ MT DTT DM6OCSJ MA Inhibitor DM6OCSJ RN Inhibitors of JAK-family kinases: an update on the patent literature 2013-2015, part 1.Expert Opin Ther Pat. 2017 Feb;27(2):127-143. DM6OCSJ RU https://www.ncbi.nlm.nih.gov/pubmed/27774824 DM1VOPH DI DM1VOPH DM1VOPH DN PMID27774824-Compound-Figure8Example99 DM1VOPH MI TTRMX3V DM1VOPH MN Janus kinase 2 (JAK-2) DM1VOPH MT DTT DM1VOPH MA Inhibitor DM1VOPH RN Inhibitors of JAK-family kinases: an update on the patent literature 2013-2015, part 1.Expert Opin Ther Pat. 2017 Feb;27(2):127-143. DM1VOPH RU https://www.ncbi.nlm.nih.gov/pubmed/27774824 DMXAV42 DI DMXAV42 DMXAV42 DN PMID27774824-Compound-Figure9Example2down DMXAV42 MI TTZ04AF DMXAV42 MN EGFR T790M mutant (EGFR T790M) DMXAV42 MT DTT DMXAV42 MA Inhibitor DMXAV42 RN Inhibitors of JAK-family kinases: an update on the patent literature 2013-2015, part 1.Expert Opin Ther Pat. 2017 Feb;27(2):127-143. DMXAV42 RU https://www.ncbi.nlm.nih.gov/pubmed/27774824 DMXAV42 DI DMXAV42 DMXAV42 DN PMID27774824-Compound-Figure9Example2down DMXAV42 MI TT6DM01 DMXAV42 MN Janus kinase 1 (JAK-1) DMXAV42 MT DTT DMXAV42 MA Inhibitor DMXAV42 RN Inhibitors of JAK-family kinases: an update on the patent literature 2013-2015, part 1.Expert Opin Ther Pat. 2017 Feb;27(2):127-143. DMXAV42 RU https://www.ncbi.nlm.nih.gov/pubmed/27774824 DMXAV42 DI DMXAV42 DMXAV42 DN PMID27774824-Compound-Figure9Example2down DMXAV42 MI TTRMX3V DMXAV42 MN Janus kinase 2 (JAK-2) DMXAV42 MT DTT DMXAV42 MA Inhibitor DMXAV42 RN Inhibitors of JAK-family kinases: an update on the patent literature 2013-2015, part 1.Expert Opin Ther Pat. 2017 Feb;27(2):127-143. DMXAV42 RU https://www.ncbi.nlm.nih.gov/pubmed/27774824 DMXAV42 DI DMXAV42 DMXAV42 DN PMID27774824-Compound-Figure9Example2down DMXAV42 MI TTT7PJU DMXAV42 MN Janus kinase 3 (JAK-3) DMXAV42 MT DTT DMXAV42 MA Inhibitor DMXAV42 RN Inhibitors of JAK-family kinases: an update on the patent literature 2013-2015, part 1.Expert Opin Ther Pat. 2017 Feb;27(2):127-143. DMXAV42 RU https://www.ncbi.nlm.nih.gov/pubmed/27774824 DMXAV42 DI DMXAV42 DMXAV42 DN PMID27774824-Compound-Figure9Example2down DMXAV42 MI TTBYWP2 DMXAV42 MN TYK2 tyrosine kinase (TYK2) DMXAV42 MT DTT DMXAV42 MA Inhibitor DMXAV42 RN Inhibitors of JAK-family kinases: an update on the patent literature 2013-2015, part 1.Expert Opin Ther Pat. 2017 Feb;27(2):127-143. DMXAV42 RU https://www.ncbi.nlm.nih.gov/pubmed/27774824 DMXAV42 DI DMXAV42 DMXAV42 DN PMID27774824-Compound-Figure9Example2down DMXAV42 MI TT3PJMV DMXAV42 MN Tyrosine-protein kinase ABL1 (ABL) DMXAV42 MT DTT DMXAV42 MA Inhibitor DMXAV42 RN Inhibitors of JAK-family kinases: an update on the patent literature 2013-2015, part 1.Expert Opin Ther Pat. 2017 Feb;27(2):127-143. DMXAV42 RU https://www.ncbi.nlm.nih.gov/pubmed/27774824 DME3TMS DI DME3TMS DME3TMS DN PMID27774824-Compound-Figure9Example2up DME3TMS MI TT6DM01 DME3TMS MN Janus kinase 1 (JAK-1) DME3TMS MT DTT DME3TMS MA Inhibitor DME3TMS RN Inhibitors of JAK-family kinases: an update on the patent literature 2013-2015, part 1.Expert Opin Ther Pat. 2017 Feb;27(2):127-143. DME3TMS RU https://www.ncbi.nlm.nih.gov/pubmed/27774824 DME3TMS DI DME3TMS DME3TMS DN PMID27774824-Compound-Figure9Example2up DME3TMS MI TTRMX3V DME3TMS MN Janus kinase 2 (JAK-2) DME3TMS MT DTT DME3TMS MA Inhibitor DME3TMS RN Inhibitors of JAK-family kinases: an update on the patent literature 2013-2015, part 1.Expert Opin Ther Pat. 2017 Feb;27(2):127-143. DME3TMS RU https://www.ncbi.nlm.nih.gov/pubmed/27774824 DME3TMS DI DME3TMS DME3TMS DN PMID27774824-Compound-Figure9Example2up DME3TMS MI TTT7PJU DME3TMS MN Janus kinase 3 (JAK-3) DME3TMS MT DTT DME3TMS MA Inhibitor DME3TMS RN Inhibitors of JAK-family kinases: an update on the patent literature 2013-2015, part 1.Expert Opin Ther Pat. 2017 Feb;27(2):127-143. DME3TMS RU https://www.ncbi.nlm.nih.gov/pubmed/27774824 DME3TMS DI DME3TMS DME3TMS DN PMID27774824-Compound-Figure9Example2up DME3TMS MI TTBYWP2 DME3TMS MN TYK2 tyrosine kinase (TYK2) DME3TMS MT DTT DME3TMS MA Inhibitor DME3TMS RN Inhibitors of JAK-family kinases: an update on the patent literature 2013-2015, part 1.Expert Opin Ther Pat. 2017 Feb;27(2):127-143. DME3TMS RU https://www.ncbi.nlm.nih.gov/pubmed/27774824 DME3TMS DI DME3TMS DME3TMS DN PMID27774824-Compound-Figure9Example2up DME3TMS MI TT3PJMV DME3TMS MN Tyrosine-protein kinase ABL1 (ABL) DME3TMS MT DTT DME3TMS MA Inhibitor DME3TMS RN Inhibitors of JAK-family kinases: an update on the patent literature 2013-2015, part 1.Expert Opin Ther Pat. 2017 Feb;27(2):127-143. DME3TMS RU https://www.ncbi.nlm.nih.gov/pubmed/27774824 DMHPK31 DI DMHPK31 DMHPK31 DN PMID27788040-Compound-5 DMHPK31 MI TTV1C0Z DMHPK31 MN Neuropeptide S receptor (NPSR) DMHPK31 MT DTT DMHPK31 MA Antagonist DMHPK31 RN Neuropeptide S receptor ligands: a patent review (2005-2016).Expert Opin Ther Pat. 2017 Mar;27(3):347-362. DMHPK31 RU https://www.ncbi.nlm.nih.gov/pubmed/27788040 DMW3X1I DI DMW3X1I DMW3X1I DN PMID27788040-Compound-5a DMW3X1I MI TTV1C0Z DMW3X1I MN Neuropeptide S receptor (NPSR) DMW3X1I MT DTT DMW3X1I MA Antagonist DMW3X1I RN Neuropeptide S receptor ligands: a patent review (2005-2016).Expert Opin Ther Pat. 2017 Mar;27(3):347-362. DMW3X1I RU https://www.ncbi.nlm.nih.gov/pubmed/27788040 DMPQKXR DI DMPQKXR DMPQKXR DN PMID27788040-Compound-5b DMPQKXR MI TTV1C0Z DMPQKXR MN Neuropeptide S receptor (NPSR) DMPQKXR MT DTT DMPQKXR MA Antagonist DMPQKXR RN Neuropeptide S receptor ligands: a patent review (2005-2016).Expert Opin Ther Pat. 2017 Mar;27(3):347-362. DMPQKXR RU https://www.ncbi.nlm.nih.gov/pubmed/27788040 DMK72JS DI DMK72JS DMK72JS DN PMID27788040-Compound-5c DMK72JS MI TTV1C0Z DMK72JS MN Neuropeptide S receptor (NPSR) DMK72JS MT DTT DMK72JS MA Antagonist DMK72JS RN Neuropeptide S receptor ligands: a patent review (2005-2016).Expert Opin Ther Pat. 2017 Mar;27(3):347-362. DMK72JS RU https://www.ncbi.nlm.nih.gov/pubmed/27788040 DMHX8OF DI DMHX8OF DMHX8OF DN PMID27788040-Compound-6 DMHX8OF MI TTV1C0Z DMHX8OF MN Neuropeptide S receptor (NPSR) DMHX8OF MT DTT DMHX8OF MA Antagonist DMHX8OF RN Neuropeptide S receptor ligands: a patent review (2005-2016).Expert Opin Ther Pat. 2017 Mar;27(3):347-362. DMHX8OF RU https://www.ncbi.nlm.nih.gov/pubmed/27788040 DM4QA6X DI DM4QA6X DM4QA6X DN PMID27788040-Compound-6a DM4QA6X MI TTV1C0Z DM4QA6X MN Neuropeptide S receptor (NPSR) DM4QA6X MT DTT DM4QA6X MA Antagonist DM4QA6X RN Neuropeptide S receptor ligands: a patent review (2005-2016).Expert Opin Ther Pat. 2017 Mar;27(3):347-362. DM4QA6X RU https://www.ncbi.nlm.nih.gov/pubmed/27788040 DMD3U96 DI DMD3U96 DMD3U96 DN PMID27788040-Compound-6b DMD3U96 MI TTV1C0Z DMD3U96 MN Neuropeptide S receptor (NPSR) DMD3U96 MT DTT DMD3U96 MA Antagonist DMD3U96 RN Neuropeptide S receptor ligands: a patent review (2005-2016).Expert Opin Ther Pat. 2017 Mar;27(3):347-362. DMD3U96 RU https://www.ncbi.nlm.nih.gov/pubmed/27788040 DMNRU35 DI DMNRU35 DMNRU35 DN PMID27788040-Compound-6c DMNRU35 MI TTV1C0Z DMNRU35 MN Neuropeptide S receptor (NPSR) DMNRU35 MT DTT DMNRU35 MA Antagonist DMNRU35 RN Neuropeptide S receptor ligands: a patent review (2005-2016).Expert Opin Ther Pat. 2017 Mar;27(3):347-362. DMNRU35 RU https://www.ncbi.nlm.nih.gov/pubmed/27788040 DM3G21F DI DM3G21F DM3G21F DN PMID27828716-Compound-15 DM3G21F MI TTRZQE3 DM3G21F MN Glycogen synthase kinase-3 alpha (GSK-3A) DM3G21F MT DTT DM3G21F MA Inhibitor DM3G21F RN Glycogen synthase kinase 3 (GSK-3) inhibitors: a patent update (2014-2015).Expert Opin Ther Pat. 2017 Jun;27(6):657-666. DM3G21F RU https://www.ncbi.nlm.nih.gov/pubmed/27828716 DM9VXY7 DI DM9VXY7 DM9VXY7 DN PMID27828716-Compound-16 DM9VXY7 MI TTRZQE3 DM9VXY7 MN Glycogen synthase kinase-3 alpha (GSK-3A) DM9VXY7 MT DTT DM9VXY7 MA Inhibitor DM9VXY7 RN Glycogen synthase kinase 3 (GSK-3) inhibitors: a patent update (2014-2015).Expert Opin Ther Pat. 2017 Jun;27(6):657-666. DM9VXY7 RU https://www.ncbi.nlm.nih.gov/pubmed/27828716 DMR7V9E DI DMR7V9E DMR7V9E DN PMID27828716-Compound-17 DMR7V9E MI TTRZQE3 DMR7V9E MN Glycogen synthase kinase-3 alpha (GSK-3A) DMR7V9E MT DTT DMR7V9E MA Inhibitor DMR7V9E RN Glycogen synthase kinase 3 (GSK-3) inhibitors: a patent update (2014-2015).Expert Opin Ther Pat. 2017 Jun;27(6):657-666. DMR7V9E RU https://www.ncbi.nlm.nih.gov/pubmed/27828716 DMNR6KL DI DMNR6KL DMNR6KL DN PMID27828716-Compound-18 DMNR6KL MI TTRZQE3 DMNR6KL MN Glycogen synthase kinase-3 alpha (GSK-3A) DMNR6KL MT DTT DMNR6KL MA Inhibitor DMNR6KL RN Glycogen synthase kinase 3 (GSK-3) inhibitors: a patent update (2014-2015).Expert Opin Ther Pat. 2017 Jun;27(6):657-666. DMNR6KL RU https://www.ncbi.nlm.nih.gov/pubmed/27828716 DM8V7QH DI DM8V7QH DM8V7QH DN PMID27828716-Compound-19 DM8V7QH MI TTRZQE3 DM8V7QH MN Glycogen synthase kinase-3 alpha (GSK-3A) DM8V7QH MT DTT DM8V7QH MA Inhibitor DM8V7QH RN Glycogen synthase kinase 3 (GSK-3) inhibitors: a patent update (2014-2015).Expert Opin Ther Pat. 2017 Jun;27(6):657-666. DM8V7QH RU https://www.ncbi.nlm.nih.gov/pubmed/27828716 DMDA3PN DI DMDA3PN DMDA3PN DN PMID27828716-Compound-20 DMDA3PN MI TTRZQE3 DMDA3PN MN Glycogen synthase kinase-3 alpha (GSK-3A) DMDA3PN MT DTT DMDA3PN MA Inhibitor DMDA3PN RN Glycogen synthase kinase 3 (GSK-3) inhibitors: a patent update (2014-2015).Expert Opin Ther Pat. 2017 Jun;27(6):657-666. DMDA3PN RU https://www.ncbi.nlm.nih.gov/pubmed/27828716 DMO1NAR DI DMO1NAR DMO1NAR DN PMID27828716-Compound-21 DMO1NAR MI TTRZQE3 DMO1NAR MN Glycogen synthase kinase-3 alpha (GSK-3A) DMO1NAR MT DTT DMO1NAR MA Inhibitor DMO1NAR RN Glycogen synthase kinase 3 (GSK-3) inhibitors: a patent update (2014-2015).Expert Opin Ther Pat. 2017 Jun;27(6):657-666. DMO1NAR RU https://www.ncbi.nlm.nih.gov/pubmed/27828716 DMUM5L6 DI DMUM5L6 DMUM5L6 DN PMID27828716-Compound-BIO-acetoxime DMUM5L6 MI TTRZQE3 DMUM5L6 MN Glycogen synthase kinase-3 alpha (GSK-3A) DMUM5L6 MT DTT DMUM5L6 MA Inhibitor DMUM5L6 RN Glycogen synthase kinase 3 (GSK-3) inhibitors: a patent update (2014-2015).Expert Opin Ther Pat. 2017 Jun;27(6):657-666. DMUM5L6 RU https://www.ncbi.nlm.nih.gov/pubmed/27828716 DMY9WHZ DI DMY9WHZ DMY9WHZ DN PMID27841036-Compound-23 DMY9WHZ MI TTEBCY8 DMY9WHZ MN Poly [ADP-ribose] polymerase (PARP) DMY9WHZ MT DTT DMY9WHZ MA Inhibitor DMY9WHZ RN PARP inhibitors as antitumor agents: a patent update (2013-2015).Expert Opin Ther Pat. 2017 Mar;27(3):363-382. DMY9WHZ RU https://www.ncbi.nlm.nih.gov/pubmed/27841036 DM9VMJ3 DI DM9VMJ3 DM9VMJ3 DN PMID27841036-Compound-24 DM9VMJ3 MI TTEBCY8 DM9VMJ3 MN Poly [ADP-ribose] polymerase (PARP) DM9VMJ3 MT DTT DM9VMJ3 MA Inhibitor DM9VMJ3 RN PARP inhibitors as antitumor agents: a patent update (2013-2015).Expert Opin Ther Pat. 2017 Mar;27(3):363-382. DM9VMJ3 RU https://www.ncbi.nlm.nih.gov/pubmed/27841036 DMGXI95 DI DMGXI95 DMGXI95 DN PMID27841036-Compound-33 DMGXI95 MI TTVDSZ0 DMGXI95 MN Poly [ADP-ribose] polymerase 1 (PARP1) DMGXI95 MT DTT DMGXI95 MA Inhibitor DMGXI95 RN PARP inhibitors as antitumor agents: a patent update (2013-2015).Expert Opin Ther Pat. 2017 Mar;27(3):363-382. DMGXI95 RU https://www.ncbi.nlm.nih.gov/pubmed/27841036 DMHIV2L DI DMHIV2L DMHIV2L DN PMID27841036-Compound-36 DMHIV2L MI TTEBCY8 DMHIV2L MN Poly [ADP-ribose] polymerase (PARP) DMHIV2L MT DTT DMHIV2L MA Inhibitor DMHIV2L RN PARP inhibitors as antitumor agents: a patent update (2013-2015).Expert Opin Ther Pat. 2017 Mar;27(3):363-382. DMHIV2L RU https://www.ncbi.nlm.nih.gov/pubmed/27841036 DM1KJAQ DI DM1KJAQ DM1KJAQ DN PMID27841036-Compound-38 DM1KJAQ MI TTEBCY8 DM1KJAQ MN Poly [ADP-ribose] polymerase (PARP) DM1KJAQ MT DTT DM1KJAQ MA Inhibitor DM1KJAQ RN PARP inhibitors as antitumor agents: a patent update (2013-2015).Expert Opin Ther Pat. 2017 Mar;27(3):363-382. DM1KJAQ RU https://www.ncbi.nlm.nih.gov/pubmed/27841036 DM3FAIS DI DM3FAIS DM3FAIS DN PMID27841036-Compound-V DM3FAIS MI TTEBCY8 DM3FAIS MN Poly [ADP-ribose] polymerase (PARP) DM3FAIS MT DTT DM3FAIS MA Inhibitor DM3FAIS RN PARP inhibitors as antitumor agents: a patent update (2013-2015).Expert Opin Ther Pat. 2017 Mar;27(3):363-382. DM3FAIS RU https://www.ncbi.nlm.nih.gov/pubmed/27841036 DM1HPY7 DI DM1HPY7 DM1HPY7 DN PMID27841036-Compound-XI DM1HPY7 MI TTEBCY8 DM1HPY7 MN Poly [ADP-ribose] polymerase (PARP) DM1HPY7 MT DTT DM1HPY7 MA Inhibitor DM1HPY7 RN PARP inhibitors as antitumor agents: a patent update (2013-2015).Expert Opin Ther Pat. 2017 Mar;27(3):363-382. DM1HPY7 RU https://www.ncbi.nlm.nih.gov/pubmed/27841036 DM9K5BZ DI DM9K5BZ DM9K5BZ DN PMID27841036-Compound-XVII DM9K5BZ MI TTEBCY8 DM9K5BZ MN Poly [ADP-ribose] polymerase (PARP) DM9K5BZ MT DTT DM9K5BZ MA Inhibitor DM9K5BZ RN PARP inhibitors as antitumor agents: a patent update (2013-2015).Expert Opin Ther Pat. 2017 Mar;27(3):363-382. DM9K5BZ RU https://www.ncbi.nlm.nih.gov/pubmed/27841036 DME2IHD DI DME2IHD DME2IHD DN PMID27841045-Compound-129 DME2IHD MI TT7RJY8 DME2IHD MN Xanthine dehydrogenase/oxidase (XDH) DME2IHD MT DTT DME2IHD MA Inhibitor DME2IHD RN An updated patent review: xanthine oxidase inhibitors for the treatment of hyperuricemia and gout (2011-2015).Expert Opin Ther Pat. 2017 Mar;27(3):311-345. DME2IHD RU https://www.ncbi.nlm.nih.gov/pubmed/27841045 DM2AVEG DI DM2AVEG DM2AVEG DN PMID27841045-Compound-130 DM2AVEG MI TT7RJY8 DM2AVEG MN Xanthine dehydrogenase/oxidase (XDH) DM2AVEG MT DTT DM2AVEG MA Inhibitor DM2AVEG RN An updated patent review: xanthine oxidase inhibitors for the treatment of hyperuricemia and gout (2011-2015).Expert Opin Ther Pat. 2017 Mar;27(3):311-345. DM2AVEG RU https://www.ncbi.nlm.nih.gov/pubmed/27841045 DMIKTVL DI DMIKTVL DMIKTVL DN PMID27841045-Compound-131 DMIKTVL MI TT7RJY8 DMIKTVL MN Xanthine dehydrogenase/oxidase (XDH) DMIKTVL MT DTT DMIKTVL MA Inhibitor DMIKTVL RN An updated patent review: xanthine oxidase inhibitors for the treatment of hyperuricemia and gout (2011-2015).Expert Opin Ther Pat. 2017 Mar;27(3):311-345. DMIKTVL RU https://www.ncbi.nlm.nih.gov/pubmed/27841045 DMCQB93 DI DMCQB93 DMCQB93 DN PMID27841045-Compound-132 DMCQB93 MI TT7RJY8 DMCQB93 MN Xanthine dehydrogenase/oxidase (XDH) DMCQB93 MT DTT DMCQB93 MA Inhibitor DMCQB93 RN An updated patent review: xanthine oxidase inhibitors for the treatment of hyperuricemia and gout (2011-2015).Expert Opin Ther Pat. 2017 Mar;27(3):311-345. DMCQB93 RU https://www.ncbi.nlm.nih.gov/pubmed/27841045 DMXPO6T DI DMXPO6T DMXPO6T DN PMID27841045-Compound-133 DMXPO6T MI TT7RJY8 DMXPO6T MN Xanthine dehydrogenase/oxidase (XDH) DMXPO6T MT DTT DMXPO6T MA Inhibitor DMXPO6T RN An updated patent review: xanthine oxidase inhibitors for the treatment of hyperuricemia and gout (2011-2015).Expert Opin Ther Pat. 2017 Mar;27(3):311-345. DMXPO6T RU https://www.ncbi.nlm.nih.gov/pubmed/27841045 DMY3U7N DI DMY3U7N DMY3U7N DN PMID27841045-Compound-134 DMY3U7N MI TT7RJY8 DMY3U7N MN Xanthine dehydrogenase/oxidase (XDH) DMY3U7N MT DTT DMY3U7N MA Inhibitor DMY3U7N RN An updated patent review: xanthine oxidase inhibitors for the treatment of hyperuricemia and gout (2011-2015).Expert Opin Ther Pat. 2017 Mar;27(3):311-345. DMY3U7N RU https://www.ncbi.nlm.nih.gov/pubmed/27841045 DMVR9TJ DI DMVR9TJ DMVR9TJ DN PMID27841045-Compound-135 DMVR9TJ MI TT7RJY8 DMVR9TJ MN Xanthine dehydrogenase/oxidase (XDH) DMVR9TJ MT DTT DMVR9TJ MA Inhibitor DMVR9TJ RN An updated patent review: xanthine oxidase inhibitors for the treatment of hyperuricemia and gout (2011-2015).Expert Opin Ther Pat. 2017 Mar;27(3):311-345. DMVR9TJ RU https://www.ncbi.nlm.nih.gov/pubmed/27841045 DM0KR8E DI DM0KR8E DM0KR8E DN PMID27841045-Compound-136 DM0KR8E MI TT7RJY8 DM0KR8E MN Xanthine dehydrogenase/oxidase (XDH) DM0KR8E MT DTT DM0KR8E MA Inhibitor DM0KR8E RN An updated patent review: xanthine oxidase inhibitors for the treatment of hyperuricemia and gout (2011-2015).Expert Opin Ther Pat. 2017 Mar;27(3):311-345. DM0KR8E RU https://www.ncbi.nlm.nih.gov/pubmed/27841045 DML25WY DI DML25WY DML25WY DN PMID27841045-Compound-137 DML25WY MI TT7RJY8 DML25WY MN Xanthine dehydrogenase/oxidase (XDH) DML25WY MT DTT DML25WY MA Inhibitor DML25WY RN An updated patent review: xanthine oxidase inhibitors for the treatment of hyperuricemia and gout (2011-2015).Expert Opin Ther Pat. 2017 Mar;27(3):311-345. DML25WY RU https://www.ncbi.nlm.nih.gov/pubmed/27841045 DMR7MBY DI DMR7MBY DMR7MBY DN PMID27841045-Compound-143 DMR7MBY MI TT7RJY8 DMR7MBY MN Xanthine dehydrogenase/oxidase (XDH) DMR7MBY MT DTT DMR7MBY MA Inhibitor DMR7MBY RN An updated patent review: xanthine oxidase inhibitors for the treatment of hyperuricemia and gout (2011-2015).Expert Opin Ther Pat. 2017 Mar;27(3):311-345. DMR7MBY RU https://www.ncbi.nlm.nih.gov/pubmed/27841045 DMR43JE DI DMR43JE DMR43JE DN PMID27841045-Compound-144 DMR43JE MI TT7RJY8 DMR43JE MN Xanthine dehydrogenase/oxidase (XDH) DMR43JE MT DTT DMR43JE MA Inhibitor DMR43JE RN An updated patent review: xanthine oxidase inhibitors for the treatment of hyperuricemia and gout (2011-2015).Expert Opin Ther Pat. 2017 Mar;27(3):311-345. DMR43JE RU https://www.ncbi.nlm.nih.gov/pubmed/27841045 DMAJRP1 DI DMAJRP1 DMAJRP1 DN PMID27841045-Compound-145 DMAJRP1 MI TT7RJY8 DMAJRP1 MN Xanthine dehydrogenase/oxidase (XDH) DMAJRP1 MT DTT DMAJRP1 MA Inhibitor DMAJRP1 RN An updated patent review: xanthine oxidase inhibitors for the treatment of hyperuricemia and gout (2011-2015).Expert Opin Ther Pat. 2017 Mar;27(3):311-345. DMAJRP1 RU https://www.ncbi.nlm.nih.gov/pubmed/27841045 DM675SX DI DM675SX DM675SX DN PMID27841045-Compound-155 DM675SX MI TT7RJY8 DM675SX MN Xanthine dehydrogenase/oxidase (XDH) DM675SX MT DTT DM675SX MA Inhibitor DM675SX RN An updated patent review: xanthine oxidase inhibitors for the treatment of hyperuricemia and gout (2011-2015).Expert Opin Ther Pat. 2017 Mar;27(3):311-345. DM675SX RU https://www.ncbi.nlm.nih.gov/pubmed/27841045 DML4AVX DI DML4AVX DML4AVX DN PMID27841045-Compound-156 DML4AVX MI TT7RJY8 DML4AVX MN Xanthine dehydrogenase/oxidase (XDH) DML4AVX MT DTT DML4AVX MA Inhibitor DML4AVX RN An updated patent review: xanthine oxidase inhibitors for the treatment of hyperuricemia and gout (2011-2015).Expert Opin Ther Pat. 2017 Mar;27(3):311-345. DML4AVX RU https://www.ncbi.nlm.nih.gov/pubmed/27841045 DM7EXNI DI DM7EXNI DM7EXNI DN PMID27841045-Compound-157 DM7EXNI MI TT7RJY8 DM7EXNI MN Xanthine dehydrogenase/oxidase (XDH) DM7EXNI MT DTT DM7EXNI MA Inhibitor DM7EXNI RN An updated patent review: xanthine oxidase inhibitors for the treatment of hyperuricemia and gout (2011-2015).Expert Opin Ther Pat. 2017 Mar;27(3):311-345. DM7EXNI RU https://www.ncbi.nlm.nih.gov/pubmed/27841045 DMBNHI7 DI DMBNHI7 DMBNHI7 DN PMID27967267-Compound-12 DMBNHI7 MI TT1RS9F DMBNHI7 MN Acetylcholinesterase (AChE) DMBNHI7 MT DTT DMBNHI7 MA Inhibitor DMBNHI7 RN Recent advances in acetylcholinesterase Inhibitors and Reactivators: an update on the patent literature (2012-2015).Expert Opin Ther Pat. 2017 Apr;27(4):455-476. DMBNHI7 RU https://www.ncbi.nlm.nih.gov/pubmed/27967267 DMY5UB8 DI DMY5UB8 DMY5UB8 DN PMID27967267-Compound-13 DMY5UB8 MI TT1RS9F DMY5UB8 MN Acetylcholinesterase (AChE) DMY5UB8 MT DTT DMY5UB8 MA Inhibitor DMY5UB8 RN Recent advances in acetylcholinesterase Inhibitors and Reactivators: an update on the patent literature (2012-2015).Expert Opin Ther Pat. 2017 Apr;27(4):455-476. DMY5UB8 RU https://www.ncbi.nlm.nih.gov/pubmed/27967267 DMGI5Z8 DI DMGI5Z8 DMGI5Z8 DN PMID27967267-Compound-14 DMGI5Z8 MI TT1RS9F DMGI5Z8 MN Acetylcholinesterase (AChE) DMGI5Z8 MT DTT DMGI5Z8 MA Inhibitor DMGI5Z8 RN Recent advances in acetylcholinesterase Inhibitors and Reactivators: an update on the patent literature (2012-2015).Expert Opin Ther Pat. 2017 Apr;27(4):455-476. DMGI5Z8 RU https://www.ncbi.nlm.nih.gov/pubmed/27967267 DMEW46T DI DMEW46T DMEW46T DN PMID27967267-Compound-15 DMEW46T MI TT1RS9F DMEW46T MN Acetylcholinesterase (AChE) DMEW46T MT DTT DMEW46T MA Inhibitor DMEW46T RN Recent advances in acetylcholinesterase Inhibitors and Reactivators: an update on the patent literature (2012-2015).Expert Opin Ther Pat. 2017 Apr;27(4):455-476. DMEW46T RU https://www.ncbi.nlm.nih.gov/pubmed/27967267 DMO0QME DI DMO0QME DMO0QME DN PMID27967267-Compound-27 DMO0QME MI TT1RS9F DMO0QME MN Acetylcholinesterase (AChE) DMO0QME MT DTT DMO0QME RN Recent advances in acetylcholinesterase Inhibitors and Reactivators: an update on the patent literature (2012-2015).Expert Opin Ther Pat. 2017 Apr;27(4):455-476. DMO0QME RU https://www.ncbi.nlm.nih.gov/pubmed/27967267 DMVM31E DI DMVM31E DMVM31E DN PMID27967267-Compound-28 DMVM31E MI TT1RS9F DMVM31E MN Acetylcholinesterase (AChE) DMVM31E MT DTT DMVM31E RN Recent advances in acetylcholinesterase Inhibitors and Reactivators: an update on the patent literature (2012-2015).Expert Opin Ther Pat. 2017 Apr;27(4):455-476. DMVM31E RU https://www.ncbi.nlm.nih.gov/pubmed/27967267 DM7JIF0 DI DM7JIF0 DM7JIF0 DN PMID27967267-Compound-3 DM7JIF0 MI TT1RS9F DM7JIF0 MN Acetylcholinesterase (AChE) DM7JIF0 MT DTT DM7JIF0 MA Inhibitor DM7JIF0 RN Recent advances in acetylcholinesterase Inhibitors and Reactivators: an update on the patent literature (2012-2015).Expert Opin Ther Pat. 2017 Apr;27(4):455-476. DM7JIF0 RU https://www.ncbi.nlm.nih.gov/pubmed/27967267 DM7CWZ4 DI DM7CWZ4 DM7CWZ4 DN PMID27967267-Compound-36 DM7CWZ4 MI TT1RS9F DM7CWZ4 MN Acetylcholinesterase (AChE) DM7CWZ4 MT DTT DM7CWZ4 RN Recent advances in acetylcholinesterase Inhibitors and Reactivators: an update on the patent literature (2012-2015).Expert Opin Ther Pat. 2017 Apr;27(4):455-476. DM7CWZ4 RU https://www.ncbi.nlm.nih.gov/pubmed/27967267 DMQOAJP DI DMQOAJP DMQOAJP DN PMID27967267-Compound-39 DMQOAJP MI TT1RS9F DMQOAJP MN Acetylcholinesterase (AChE) DMQOAJP MT DTT DMQOAJP MA Inhibitor DMQOAJP RN Recent advances in acetylcholinesterase Inhibitors and Reactivators: an update on the patent literature (2012-2015).Expert Opin Ther Pat. 2017 Apr;27(4):455-476. DMQOAJP RU https://www.ncbi.nlm.nih.gov/pubmed/27967267 DM68KPS DI DM68KPS DM68KPS DN PMID27967267-Compound-42 DM68KPS MI TT1RS9F DM68KPS MN Acetylcholinesterase (AChE) DM68KPS MT DTT DM68KPS MA Inhibitor DM68KPS RN Recent advances in acetylcholinesterase Inhibitors and Reactivators: an update on the patent literature (2012-2015).Expert Opin Ther Pat. 2017 Apr;27(4):455-476. DM68KPS RU https://www.ncbi.nlm.nih.gov/pubmed/27967267 DM12X0P DI DM12X0P DM12X0P DN PMID27967267-Compound-43 DM12X0P MI TT1RS9F DM12X0P MN Acetylcholinesterase (AChE) DM12X0P MT DTT DM12X0P MA Inhibitor DM12X0P RN Recent advances in acetylcholinesterase Inhibitors and Reactivators: an update on the patent literature (2012-2015).Expert Opin Ther Pat. 2017 Apr;27(4):455-476. DM12X0P RU https://www.ncbi.nlm.nih.gov/pubmed/27967267 DMEXATH DI DMEXATH DMEXATH DN PMID27967267-Compound-47 DMEXATH MI TT1RS9F DMEXATH MN Acetylcholinesterase (AChE) DMEXATH MT DTT DMEXATH MA Reactivator DMEXATH RN Recent advances in acetylcholinesterase Inhibitors and Reactivators: an update on the patent literature (2012-2015).Expert Opin Ther Pat. 2017 Apr;27(4):455-476. DMEXATH RU https://www.ncbi.nlm.nih.gov/pubmed/27967267 DM81A50 DI DM81A50 DM81A50 DN PMID27967267-Compound-48 DM81A50 MI TT1RS9F DM81A50 MN Acetylcholinesterase (AChE) DM81A50 MT DTT DM81A50 MA Reactivator DM81A50 RN Recent advances in acetylcholinesterase Inhibitors and Reactivators: an update on the patent literature (2012-2015).Expert Opin Ther Pat. 2017 Apr;27(4):455-476. DM81A50 RU https://www.ncbi.nlm.nih.gov/pubmed/27967267 DMQTRFX DI DMQTRFX DMQTRFX DN PMID27967267-Compound-49 DMQTRFX MI TT1RS9F DMQTRFX MN Acetylcholinesterase (AChE) DMQTRFX MT DTT DMQTRFX MA Reactivator DMQTRFX RN Recent advances in acetylcholinesterase Inhibitors and Reactivators: an update on the patent literature (2012-2015).Expert Opin Ther Pat. 2017 Apr;27(4):455-476. DMQTRFX RU https://www.ncbi.nlm.nih.gov/pubmed/27967267 DMNH891 DI DMNH891 DMNH891 DN PMID27967267-Compound-51 DMNH891 MI TT1RS9F DMNH891 MN Acetylcholinesterase (AChE) DMNH891 MT DTT DMNH891 MA Reactivator DMNH891 RN Recent advances in acetylcholinesterase Inhibitors and Reactivators: an update on the patent literature (2012-2015).Expert Opin Ther Pat. 2017 Apr;27(4):455-476. DMNH891 RU https://www.ncbi.nlm.nih.gov/pubmed/27967267 DMRH7ZY DI DMRH7ZY DMRH7ZY DN PMID27967267-Compound-52 DMRH7ZY MI TT1RS9F DMRH7ZY MN Acetylcholinesterase (AChE) DMRH7ZY MT DTT DMRH7ZY MA Reactivator DMRH7ZY RN Recent advances in acetylcholinesterase Inhibitors and Reactivators: an update on the patent literature (2012-2015).Expert Opin Ther Pat. 2017 Apr;27(4):455-476. DMRH7ZY RU https://www.ncbi.nlm.nih.gov/pubmed/27967267 DMAN71J DI DMAN71J DMAN71J DN PMID27967267-Compound-7 DMAN71J MI TT1RS9F DMAN71J MN Acetylcholinesterase (AChE) DMAN71J MT DTT DMAN71J MA Inhibitor DMAN71J RN Recent advances in acetylcholinesterase Inhibitors and Reactivators: an update on the patent literature (2012-2015).Expert Opin Ther Pat. 2017 Apr;27(4):455-476. DMAN71J RU https://www.ncbi.nlm.nih.gov/pubmed/27967267 DM7TLDW DI DM7TLDW DM7TLDW DN PMID27967267-Compound-neostenine DM7TLDW MI TT1RS9F DM7TLDW MN Acetylcholinesterase (AChE) DM7TLDW MT DTT DM7TLDW MA Inhibitor DM7TLDW RN Recent advances in acetylcholinesterase Inhibitors and Reactivators: an update on the patent literature (2012-2015).Expert Opin Ther Pat. 2017 Apr;27(4):455-476. DM7TLDW RU https://www.ncbi.nlm.nih.gov/pubmed/27967267 DM3CPJQ DI DM3CPJQ DM3CPJQ DN PMID27967267-Compound-neotuberostemonine DM3CPJQ MI TT1RS9F DM3CPJQ MN Acetylcholinesterase (AChE) DM3CPJQ MT DTT DM3CPJQ MA Inhibitor DM3CPJQ RN Recent advances in acetylcholinesterase Inhibitors and Reactivators: an update on the patent literature (2012-2015).Expert Opin Ther Pat. 2017 Apr;27(4):455-476. DM3CPJQ RU https://www.ncbi.nlm.nih.gov/pubmed/27967267 DM2K54D DI DM2K54D DM2K54D DN PMID27967267-Compound-stenine DM2K54D MI TT1RS9F DM2K54D MN Acetylcholinesterase (AChE) DM2K54D MT DTT DM2K54D MA Inhibitor DM2K54D RN Recent advances in acetylcholinesterase Inhibitors and Reactivators: an update on the patent literature (2012-2015).Expert Opin Ther Pat. 2017 Apr;27(4):455-476. DM2K54D RU https://www.ncbi.nlm.nih.gov/pubmed/27967267 DMTI5E3 DI DMTI5E3 DMTI5E3 DN PMID27977313-Compound-17 DMTI5E3 MI TTR7UJ3 DMTI5E3 MN Cytoplasmic thioredoxin reductase (TXNRD1) DMTI5E3 MT DTT DMTI5E3 MA Inhibitor DMTI5E3 RN Thioredoxin reductase inhibitors: a patent review.Expert Opin Ther Pat. 2017 May;27(5):547-556. DMTI5E3 RU https://www.ncbi.nlm.nih.gov/pubmed/27977313 DMIA3GH DI DMIA3GH DMIA3GH DN PMID27977313-Compound-18 DMIA3GH MI TTR7UJ3 DMIA3GH MN Cytoplasmic thioredoxin reductase (TXNRD1) DMIA3GH MT DTT DMIA3GH MA Inhibitor DMIA3GH RN Thioredoxin reductase inhibitors: a patent review.Expert Opin Ther Pat. 2017 May;27(5):547-556. DMIA3GH RU https://www.ncbi.nlm.nih.gov/pubmed/27977313 DM5JSI3 DI DM5JSI3 DM5JSI3 DN PMID27977313-Compound-19 DM5JSI3 MI TTR7UJ3 DM5JSI3 MN Cytoplasmic thioredoxin reductase (TXNRD1) DM5JSI3 MT DTT DM5JSI3 MA Inhibitor DM5JSI3 RN Thioredoxin reductase inhibitors: a patent review.Expert Opin Ther Pat. 2017 May;27(5):547-556. DM5JSI3 RU https://www.ncbi.nlm.nih.gov/pubmed/27977313 DMVYO09 DI DMVYO09 DMVYO09 DN PMID27977313-Compound-27 DMVYO09 MI TTR7UJ3 DMVYO09 MN Cytoplasmic thioredoxin reductase (TXNRD1) DMVYO09 MT DTT DMVYO09 MA Inhibitor DMVYO09 RN Thioredoxin reductase inhibitors: a patent review.Expert Opin Ther Pat. 2017 May;27(5):547-556. DMVYO09 RU https://www.ncbi.nlm.nih.gov/pubmed/27977313 DM67NBI DI DM67NBI DM67NBI DN PMID27977313-Compound-28 DM67NBI MI TTR7UJ3 DM67NBI MN Cytoplasmic thioredoxin reductase (TXNRD1) DM67NBI MT DTT DM67NBI MA Inhibitor DM67NBI RN Thioredoxin reductase inhibitors: a patent review.Expert Opin Ther Pat. 2017 May;27(5):547-556. DM67NBI RU https://www.ncbi.nlm.nih.gov/pubmed/27977313 DMIF7KG DI DMIF7KG DMIF7KG DN PMID27977313-Compound-29 DMIF7KG MI TTR7UJ3 DMIF7KG MN Cytoplasmic thioredoxin reductase (TXNRD1) DMIF7KG MT DTT DMIF7KG MA Inhibitor DMIF7KG RN Thioredoxin reductase inhibitors: a patent review.Expert Opin Ther Pat. 2017 May;27(5):547-556. DMIF7KG RU https://www.ncbi.nlm.nih.gov/pubmed/27977313 DMWHAKG DI DMWHAKG DMWHAKG DN PMID27977313-Compound-30 DMWHAKG MI TTR7UJ3 DMWHAKG MN Cytoplasmic thioredoxin reductase (TXNRD1) DMWHAKG MT DTT DMWHAKG MA Inhibitor DMWHAKG RN Thioredoxin reductase inhibitors: a patent review.Expert Opin Ther Pat. 2017 May;27(5):547-556. DMWHAKG RU https://www.ncbi.nlm.nih.gov/pubmed/27977313 DMBL5J9 DI DMBL5J9 DMBL5J9 DN PMID27977313-Compound-31 DMBL5J9 MI TTR7UJ3 DMBL5J9 MN Cytoplasmic thioredoxin reductase (TXNRD1) DMBL5J9 MT DTT DMBL5J9 MA Inhibitor DMBL5J9 RN Thioredoxin reductase inhibitors: a patent review.Expert Opin Ther Pat. 2017 May;27(5):547-556. DMBL5J9 RU https://www.ncbi.nlm.nih.gov/pubmed/27977313 DMZNM52 DI DMZNM52 DMZNM52 DN PMID27977313-Compound-32 DMZNM52 MI TTR7UJ3 DMZNM52 MN Cytoplasmic thioredoxin reductase (TXNRD1) DMZNM52 MT DTT DMZNM52 MA Inhibitor DMZNM52 RN Thioredoxin reductase inhibitors: a patent review.Expert Opin Ther Pat. 2017 May;27(5):547-556. DMZNM52 RU https://www.ncbi.nlm.nih.gov/pubmed/27977313 DM0LB21 DI DM0LB21 DM0LB21 DN PMID27977313-Compound-39 DM0LB21 MI TTR7UJ3 DM0LB21 MN Cytoplasmic thioredoxin reductase (TXNRD1) DM0LB21 MT DTT DM0LB21 MA Inhibitor DM0LB21 RN Thioredoxin reductase inhibitors: a patent review.Expert Opin Ther Pat. 2017 May;27(5):547-556. DM0LB21 RU https://www.ncbi.nlm.nih.gov/pubmed/27977313 DML4C6D DI DML4C6D DML4C6D DN PMID27977313-Compound-42 DML4C6D MI TTR7UJ3 DML4C6D MN Cytoplasmic thioredoxin reductase (TXNRD1) DML4C6D MT DTT DML4C6D MA Inhibitor DML4C6D RN Thioredoxin reductase inhibitors: a patent review.Expert Opin Ther Pat. 2017 May;27(5):547-556. DML4C6D RU https://www.ncbi.nlm.nih.gov/pubmed/27977313 DMTFLVN DI DMTFLVN DMTFLVN DN PMID27977313-Compound-43 DMTFLVN MI TTR7UJ3 DMTFLVN MN Cytoplasmic thioredoxin reductase (TXNRD1) DMTFLVN MT DTT DMTFLVN MA Inhibitor DMTFLVN RN Thioredoxin reductase inhibitors: a patent review.Expert Opin Ther Pat. 2017 May;27(5):547-556. DMTFLVN RU https://www.ncbi.nlm.nih.gov/pubmed/27977313 DM9S2UP DI DM9S2UP DM9S2UP DN PMID27977313-Compound-44 DM9S2UP MI TTR7UJ3 DM9S2UP MN Cytoplasmic thioredoxin reductase (TXNRD1) DM9S2UP MT DTT DM9S2UP MA Inhibitor DM9S2UP RN Thioredoxin reductase inhibitors: a patent review.Expert Opin Ther Pat. 2017 May;27(5):547-556. DM9S2UP RU https://www.ncbi.nlm.nih.gov/pubmed/27977313 DMSZ0GE DI DMSZ0GE DMSZ0GE DN PMID27977313-Compound-45 DMSZ0GE MI TTR7UJ3 DMSZ0GE MN Cytoplasmic thioredoxin reductase (TXNRD1) DMSZ0GE MT DTT DMSZ0GE MA Inhibitor DMSZ0GE RN Thioredoxin reductase inhibitors: a patent review.Expert Opin Ther Pat. 2017 May;27(5):547-556. DMSZ0GE RU https://www.ncbi.nlm.nih.gov/pubmed/27977313 DMGF04T DI DMGF04T DMGF04T DN PMID27977313-Compound-46 DMGF04T MI TTR7UJ3 DMGF04T MN Cytoplasmic thioredoxin reductase (TXNRD1) DMGF04T MT DTT DMGF04T MA Inhibitor DMGF04T RN Thioredoxin reductase inhibitors: a patent review.Expert Opin Ther Pat. 2017 May;27(5):547-556. DMGF04T RU https://www.ncbi.nlm.nih.gov/pubmed/27977313 DMI61KF DI DMI61KF DMI61KF DN PMID27977313-Compound-47 DMI61KF MI TTR7UJ3 DMI61KF MN Cytoplasmic thioredoxin reductase (TXNRD1) DMI61KF MT DTT DMI61KF MA Inhibitor DMI61KF RN Thioredoxin reductase inhibitors: a patent review.Expert Opin Ther Pat. 2017 May;27(5):547-556. DMI61KF RU https://www.ncbi.nlm.nih.gov/pubmed/27977313 DM4EFRL DI DM4EFRL DM4EFRL DN PMID27977313-Compound-48 DM4EFRL MI TTR7UJ3 DM4EFRL MN Cytoplasmic thioredoxin reductase (TXNRD1) DM4EFRL MT DTT DM4EFRL MA Inhibitor DM4EFRL RN Thioredoxin reductase inhibitors: a patent review.Expert Opin Ther Pat. 2017 May;27(5):547-556. DM4EFRL RU https://www.ncbi.nlm.nih.gov/pubmed/27977313 DMTUNW4 DI DMTUNW4 DMTUNW4 DN PMID27977313-Compound-5 DMTUNW4 MI TTR7UJ3 DMTUNW4 MN Cytoplasmic thioredoxin reductase (TXNRD1) DMTUNW4 MT DTT DMTUNW4 MA Inhibitor DMTUNW4 RN Thioredoxin reductase inhibitors: a patent review.Expert Opin Ther Pat. 2017 May;27(5):547-556. DMTUNW4 RU https://www.ncbi.nlm.nih.gov/pubmed/27977313 DMCUAO9 DI DMCUAO9 DMCUAO9 DN PMID27977313-Compound-6 DMCUAO9 MI TTR7UJ3 DMCUAO9 MN Cytoplasmic thioredoxin reductase (TXNRD1) DMCUAO9 MT DTT DMCUAO9 MA Inhibitor DMCUAO9 RN Thioredoxin reductase inhibitors: a patent review.Expert Opin Ther Pat. 2017 May;27(5):547-556. DMCUAO9 RU https://www.ncbi.nlm.nih.gov/pubmed/27977313 DMWIMN9 DI DMWIMN9 DMWIMN9 DN PMID27977313-Compound-7 DMWIMN9 MI TTR7UJ3 DMWIMN9 MN Cytoplasmic thioredoxin reductase (TXNRD1) DMWIMN9 MT DTT DMWIMN9 MA Inhibitor DMWIMN9 RN Thioredoxin reductase inhibitors: a patent review.Expert Opin Ther Pat. 2017 May;27(5):547-556. DMWIMN9 RU https://www.ncbi.nlm.nih.gov/pubmed/27977313 DMYFV3D DI DMYFV3D DMYFV3D DN PMID27977313-Compound-8 DMYFV3D MI TTR7UJ3 DMYFV3D MN Cytoplasmic thioredoxin reductase (TXNRD1) DMYFV3D MT DTT DMYFV3D MA Inhibitor DMYFV3D RN Thioredoxin reductase inhibitors: a patent review.Expert Opin Ther Pat. 2017 May;27(5):547-556. DMYFV3D RU https://www.ncbi.nlm.nih.gov/pubmed/27977313 DMJ6CI5 DI DMJ6CI5 DMJ6CI5 DN PMID27977313-Compound-Figure4b DMJ6CI5 MI TTR7UJ3 DMJ6CI5 MN Cytoplasmic thioredoxin reductase (TXNRD1) DMJ6CI5 MT DTT DMJ6CI5 MA Inhibitor DMJ6CI5 RN Thioredoxin reductase inhibitors: a patent review.Expert Opin Ther Pat. 2017 May;27(5):547-556. DMJ6CI5 RU https://www.ncbi.nlm.nih.gov/pubmed/27977313 DMICBFK DI DMICBFK DMICBFK DN PMID27977313-Compound-Figure6C DMICBFK MI TTR7UJ3 DMICBFK MN Cytoplasmic thioredoxin reductase (TXNRD1) DMICBFK MT DTT DMICBFK MA Inhibitor DMICBFK RN Thioredoxin reductase inhibitors: a patent review.Expert Opin Ther Pat. 2017 May;27(5):547-556. DMICBFK RU https://www.ncbi.nlm.nih.gov/pubmed/27977313 DM5QH4C DI DM5QH4C DM5QH4C DN PMID27998201-Compound-1 DM5QH4C MI TT36ETB DM5QH4C MN Cathepsin L (CTSL) DM5QH4C MT DTT DM5QH4C MA Inhibitor DM5QH4C RN Cathepsin B and L inhibitors: a patent review (2010 - present).Expert Opin Ther Pat. 2017 Jun;27(6):643-656. DM5QH4C RU https://www.ncbi.nlm.nih.gov/pubmed/27998201 DMVXTIL DI DMVXTIL DMVXTIL DN PMID27998201-Compound-10 DMVXTIL MI TTDZN01 DMVXTIL MN Cathepsin K (CTSK) DMVXTIL MT DTT DMVXTIL MA Inhibitor DMVXTIL RN Cathepsin B and L inhibitors: a patent review (2010 - present).Expert Opin Ther Pat. 2017 Jun;27(6):643-656. DMVXTIL RU https://www.ncbi.nlm.nih.gov/pubmed/27998201 DMTV5NU DI DMTV5NU DMTV5NU DN PMID27998201-Compound-11 DMTV5NU MI TTF2LRI DMTV5NU MN Cathepsin B (CTSB) DMTV5NU MT DTT DMTV5NU MA Inhibitor DMTV5NU RN Cathepsin B and L inhibitors: a patent review (2010 - present).Expert Opin Ther Pat. 2017 Jun;27(6):643-656. DMTV5NU RU https://www.ncbi.nlm.nih.gov/pubmed/27998201 DM8QZNC DI DM8QZNC DM8QZNC DN PMID27998201-Compound-12 DM8QZNC MI TTF2LRI DM8QZNC MN Cathepsin B (CTSB) DM8QZNC MT DTT DM8QZNC MA Inhibitor DM8QZNC RN Cathepsin B and L inhibitors: a patent review (2010 - present).Expert Opin Ther Pat. 2017 Jun;27(6):643-656. DM8QZNC RU https://www.ncbi.nlm.nih.gov/pubmed/27998201 DM8QZNC DI DM8QZNC DM8QZNC DN PMID27998201-Compound-12 DM8QZNC MI TTJOKD1 DM8QZNC MN Cathepsin F (CTSF) DM8QZNC MT DTT DM8QZNC MA Inhibitor DM8QZNC RN Cathepsin B and L inhibitors: a patent review (2010 - present).Expert Opin Ther Pat. 2017 Jun;27(6):643-656. DM8QZNC RU https://www.ncbi.nlm.nih.gov/pubmed/27998201 DM8QZNC DI DM8QZNC DM8QZNC DN PMID27998201-Compound-12 DM8QZNC MI TTDZN01 DM8QZNC MN Cathepsin K (CTSK) DM8QZNC MT DTT DM8QZNC MA Inhibitor DM8QZNC RN Cathepsin B and L inhibitors: a patent review (2010 - present).Expert Opin Ther Pat. 2017 Jun;27(6):643-656. DM8QZNC RU https://www.ncbi.nlm.nih.gov/pubmed/27998201 DM8QZNC DI DM8QZNC DM8QZNC DN PMID27998201-Compound-12 DM8QZNC MI TT36ETB DM8QZNC MN Cathepsin L (CTSL) DM8QZNC MT DTT DM8QZNC MA Inhibitor DM8QZNC RN Cathepsin B and L inhibitors: a patent review (2010 - present).Expert Opin Ther Pat. 2017 Jun;27(6):643-656. DM8QZNC RU https://www.ncbi.nlm.nih.gov/pubmed/27998201 DM8QZNC DI DM8QZNC DM8QZNC DN PMID27998201-Compound-12 DM8QZNC MI TTUMQVO DM8QZNC MN Cathepsin S (CTSS) DM8QZNC MT DTT DM8QZNC MA Inhibitor DM8QZNC RN Cathepsin B and L inhibitors: a patent review (2010 - present).Expert Opin Ther Pat. 2017 Jun;27(6):643-656. DM8QZNC RU https://www.ncbi.nlm.nih.gov/pubmed/27998201 DM8QZNC DI DM8QZNC DM8QZNC DN PMID27998201-Compound-12 DM8QZNC MI TTSD9T1 DM8QZNC MN Cathepsin V (CTSV) DM8QZNC MT DTT DM8QZNC MA Inhibitor DM8QZNC RN Cathepsin B and L inhibitors: a patent review (2010 - present).Expert Opin Ther Pat. 2017 Jun;27(6):643-656. DM8QZNC RU https://www.ncbi.nlm.nih.gov/pubmed/27998201 DMZHIM8 DI DMZHIM8 DMZHIM8 DN PMID27998201-Compound-13 DMZHIM8 MI TTF2LRI DMZHIM8 MN Cathepsin B (CTSB) DMZHIM8 MT DTT DMZHIM8 MA Inhibitor DMZHIM8 RN Cathepsin B and L inhibitors: a patent review (2010 - present).Expert Opin Ther Pat. 2017 Jun;27(6):643-656. DMZHIM8 RU https://www.ncbi.nlm.nih.gov/pubmed/27998201 DMOB8LU DI DMOB8LU DMOB8LU DN PMID27998201-Compound-15 DMOB8LU MI TTDZN01 DMOB8LU MN Cathepsin K (CTSK) DMOB8LU MT DTT DMOB8LU MA Inhibitor DMOB8LU RN Cathepsin B and L inhibitors: a patent review (2010 - present).Expert Opin Ther Pat. 2017 Jun;27(6):643-656. DMOB8LU RU https://www.ncbi.nlm.nih.gov/pubmed/27998201 DMOB8LU DI DMOB8LU DMOB8LU DN PMID27998201-Compound-15 DMOB8LU MI TTUMQVO DMOB8LU MN Cathepsin S (CTSS) DMOB8LU MT DTT DMOB8LU MA Inhibitor DMOB8LU RN Cathepsin B and L inhibitors: a patent review (2010 - present).Expert Opin Ther Pat. 2017 Jun;27(6):643-656. DMOB8LU RU https://www.ncbi.nlm.nih.gov/pubmed/27998201 DMAZVHJ DI DMAZVHJ DMAZVHJ DN PMID27998201-Compound-17 DMAZVHJ MI TTF2LRI DMAZVHJ MN Cathepsin B (CTSB) DMAZVHJ MT DTT DMAZVHJ MA Inhibitor DMAZVHJ RN Cathepsin B and L inhibitors: a patent review (2010 - present).Expert Opin Ther Pat. 2017 Jun;27(6):643-656. DMAZVHJ RU https://www.ncbi.nlm.nih.gov/pubmed/27998201 DMAZVHJ DI DMAZVHJ DMAZVHJ DN PMID27998201-Compound-17 DMAZVHJ MI TT36ETB DMAZVHJ MN Cathepsin L (CTSL) DMAZVHJ MT DTT DMAZVHJ MA Inhibitor DMAZVHJ RN Cathepsin B and L inhibitors: a patent review (2010 - present).Expert Opin Ther Pat. 2017 Jun;27(6):643-656. DMAZVHJ RU https://www.ncbi.nlm.nih.gov/pubmed/27998201 DMAZVHJ DI DMAZVHJ DMAZVHJ DN PMID27998201-Compound-17 DMAZVHJ MI TTUMQVO DMAZVHJ MN Cathepsin S (CTSS) DMAZVHJ MT DTT DMAZVHJ MA Inhibitor DMAZVHJ RN Cathepsin B and L inhibitors: a patent review (2010 - present).Expert Opin Ther Pat. 2017 Jun;27(6):643-656. DMAZVHJ RU https://www.ncbi.nlm.nih.gov/pubmed/27998201 DM67RMX DI DM67RMX DM67RMX DN PMID27998201-Compound-19 DM67RMX MI TT36ETB DM67RMX MN Cathepsin L (CTSL) DM67RMX MT DTT DM67RMX MA Inhibitor DM67RMX RN Cathepsin B and L inhibitors: a patent review (2010 - present).Expert Opin Ther Pat. 2017 Jun;27(6):643-656. DM67RMX RU https://www.ncbi.nlm.nih.gov/pubmed/27998201 DMMAE3C DI DMMAE3C DMMAE3C DN PMID27998201-Compound-2 DMMAE3C MI TTF2LRI DMMAE3C MN Cathepsin B (CTSB) DMMAE3C MT DTT DMMAE3C MA Inhibitor DMMAE3C RN Cathepsin B and L inhibitors: a patent review (2010 - present).Expert Opin Ther Pat. 2017 Jun;27(6):643-656. DMMAE3C RU https://www.ncbi.nlm.nih.gov/pubmed/27998201 DMS9QA7 DI DMS9QA7 DMS9QA7 DN PMID27998201-Compound-22 DMS9QA7 MI TTF2LRI DMS9QA7 MN Cathepsin B (CTSB) DMS9QA7 MT DTT DMS9QA7 MA Inhibitor DMS9QA7 RN Cathepsin B and L inhibitors: a patent review (2010 - present).Expert Opin Ther Pat. 2017 Jun;27(6):643-656. DMS9QA7 RU https://www.ncbi.nlm.nih.gov/pubmed/27998201 DM25BNZ DI DM25BNZ DM25BNZ DN PMID27998201-Compound-24 DM25BNZ MI TTF2LRI DM25BNZ MN Cathepsin B (CTSB) DM25BNZ MT DTT DM25BNZ MA Inhibitor DM25BNZ RN Cathepsin B and L inhibitors: a patent review (2010 - present).Expert Opin Ther Pat. 2017 Jun;27(6):643-656. DM25BNZ RU https://www.ncbi.nlm.nih.gov/pubmed/27998201 DMVZ0ND DI DMVZ0ND DMVZ0ND DN PMID27998201-Compound-5 DMVZ0ND MI TTF2LRI DMVZ0ND MN Cathepsin B (CTSB) DMVZ0ND MT DTT DMVZ0ND MA Inhibitor DMVZ0ND RN Cathepsin B and L inhibitors: a patent review (2010 - present).Expert Opin Ther Pat. 2017 Jun;27(6):643-656. DMVZ0ND RU https://www.ncbi.nlm.nih.gov/pubmed/27998201 DMVZ0ND DI DMVZ0ND DMVZ0ND DN PMID27998201-Compound-5 DMVZ0ND MI TTJOKD1 DMVZ0ND MN Cathepsin F (CTSF) DMVZ0ND MT DTT DMVZ0ND MA Inhibitor DMVZ0ND RN Cathepsin B and L inhibitors: a patent review (2010 - present).Expert Opin Ther Pat. 2017 Jun;27(6):643-656. DMVZ0ND RU https://www.ncbi.nlm.nih.gov/pubmed/27998201 DMVZ0ND DI DMVZ0ND DMVZ0ND DN PMID27998201-Compound-5 DMVZ0ND MI TTDZN01 DMVZ0ND MN Cathepsin K (CTSK) DMVZ0ND MT DTT DMVZ0ND MA Inhibitor DMVZ0ND RN Cathepsin B and L inhibitors: a patent review (2010 - present).Expert Opin Ther Pat. 2017 Jun;27(6):643-656. DMVZ0ND RU https://www.ncbi.nlm.nih.gov/pubmed/27998201 DMVZ0ND DI DMVZ0ND DMVZ0ND DN PMID27998201-Compound-5 DMVZ0ND MI TT36ETB DMVZ0ND MN Cathepsin L (CTSL) DMVZ0ND MT DTT DMVZ0ND MA Inhibitor DMVZ0ND RN Cathepsin B and L inhibitors: a patent review (2010 - present).Expert Opin Ther Pat. 2017 Jun;27(6):643-656. DMVZ0ND RU https://www.ncbi.nlm.nih.gov/pubmed/27998201 DMVZ0ND DI DMVZ0ND DMVZ0ND DN PMID27998201-Compound-5 DMVZ0ND MI TTUMQVO DMVZ0ND MN Cathepsin S (CTSS) DMVZ0ND MT DTT DMVZ0ND MA Inhibitor DMVZ0ND RN Cathepsin B and L inhibitors: a patent review (2010 - present).Expert Opin Ther Pat. 2017 Jun;27(6):643-656. DMVZ0ND RU https://www.ncbi.nlm.nih.gov/pubmed/27998201 DM0LGTY DI DM0LGTY DM0LGTY DN PMID27998201-Compound-6 DM0LGTY MI TT36ETB DM0LGTY MN Cathepsin L (CTSL) DM0LGTY MT DTT DM0LGTY MA Inhibitor DM0LGTY RN Cathepsin B and L inhibitors: a patent review (2010 - present).Expert Opin Ther Pat. 2017 Jun;27(6):643-656. DM0LGTY RU https://www.ncbi.nlm.nih.gov/pubmed/27998201 DM0LGTY DI DM0LGTY DM0LGTY DN PMID27998201-Compound-6 DM0LGTY MI TTUMQVO DM0LGTY MN Cathepsin S (CTSS) DM0LGTY MT DTT DM0LGTY MA Inhibitor DM0LGTY RN Cathepsin B and L inhibitors: a patent review (2010 - present).Expert Opin Ther Pat. 2017 Jun;27(6):643-656. DM0LGTY RU https://www.ncbi.nlm.nih.gov/pubmed/27998201 DMU4QYR DI DMU4QYR DMU4QYR DN PMID27998201-Compound-7 DMU4QYR MI TT36ETB DMU4QYR MN Cathepsin L (CTSL) DMU4QYR MT DTT DMU4QYR MA Inhibitor DMU4QYR RN Cathepsin B and L inhibitors: a patent review (2010 - present).Expert Opin Ther Pat. 2017 Jun;27(6):643-656. DMU4QYR RU https://www.ncbi.nlm.nih.gov/pubmed/27998201 DMU4QYR DI DMU4QYR DMU4QYR DN PMID27998201-Compound-7 DMU4QYR MI TTUMQVO DMU4QYR MN Cathepsin S (CTSS) DMU4QYR MT DTT DMU4QYR MA Inhibitor DMU4QYR RN Cathepsin B and L inhibitors: a patent review (2010 - present).Expert Opin Ther Pat. 2017 Jun;27(6):643-656. DMU4QYR RU https://www.ncbi.nlm.nih.gov/pubmed/27998201 DMZK0SY DI DMZK0SY DMZK0SY DN PMID27998201-Compound-8 DMZK0SY MI TTDZN01 DMZK0SY MN Cathepsin K (CTSK) DMZK0SY MT DTT DMZK0SY MA Inhibitor DMZK0SY RN Cathepsin B and L inhibitors: a patent review (2010 - present).Expert Opin Ther Pat. 2017 Jun;27(6):643-656. DMZK0SY RU https://www.ncbi.nlm.nih.gov/pubmed/27998201 DM1JOZN DI DM1JOZN DM1JOZN DN PMID27998201-Compound-9 DM1JOZN MI TTF2LRI DM1JOZN MN Cathepsin B (CTSB) DM1JOZN MT DTT DM1JOZN MA Inhibitor DM1JOZN RN Cathepsin B and L inhibitors: a patent review (2010 - present).Expert Opin Ther Pat. 2017 Jun;27(6):643-656. DM1JOZN RU https://www.ncbi.nlm.nih.gov/pubmed/27998201 DM1JOZN DI DM1JOZN DM1JOZN DN PMID27998201-Compound-9 DM1JOZN MI TTDZN01 DM1JOZN MN Cathepsin K (CTSK) DM1JOZN MT DTT DM1JOZN MA Inhibitor DM1JOZN RN Cathepsin B and L inhibitors: a patent review (2010 - present).Expert Opin Ther Pat. 2017 Jun;27(6):643-656. DM1JOZN RU https://www.ncbi.nlm.nih.gov/pubmed/27998201 DM1JOZN DI DM1JOZN DM1JOZN DN PMID27998201-Compound-9 DM1JOZN MI TT36ETB DM1JOZN MN Cathepsin L (CTSL) DM1JOZN MT DTT DM1JOZN MA Inhibitor DM1JOZN RN Cathepsin B and L inhibitors: a patent review (2010 - present).Expert Opin Ther Pat. 2017 Jun;27(6):643-656. DM1JOZN RU https://www.ncbi.nlm.nih.gov/pubmed/27998201 DM1JOZN DI DM1JOZN DM1JOZN DN PMID27998201-Compound-9 DM1JOZN MI TTUMQVO DM1JOZN MN Cathepsin S (CTSS) DM1JOZN MT DTT DM1JOZN MA Inhibitor DM1JOZN RN Cathepsin B and L inhibitors: a patent review (2010 - present).Expert Opin Ther Pat. 2017 Jun;27(6):643-656. DM1JOZN RU https://www.ncbi.nlm.nih.gov/pubmed/27998201 DMQ6WEN DI DMQ6WEN DMQ6WEN DN PMID28048944-Compound-11 DMQ6WEN MI TTGWKQJ DMQ6WEN MN Rho-associated protein kinase 2 (ROCK2) DMQ6WEN MT DTT DMQ6WEN MA Inhibitor DMQ6WEN RN Rho kinase inhibitors: a patent review (2014 - 2016).Expert Opin Ther Pat. 2017 Apr;27(4):507-515. DMQ6WEN RU https://www.ncbi.nlm.nih.gov/pubmed/28048944 DMPT3V9 DI DMPT3V9 DMPT3V9 DN PMID28048944-Compound-19 DMPT3V9 MI TTZN7RP DMPT3V9 MN Rho-associated protein kinase 1 (ROCK1) DMPT3V9 MT DTT DMPT3V9 MA Inhibitor DMPT3V9 RN Rho kinase inhibitors: a patent review (2014 - 2016).Expert Opin Ther Pat. 2017 Apr;27(4):507-515. DMPT3V9 RU https://www.ncbi.nlm.nih.gov/pubmed/28048944 DMPT3V9 DI DMPT3V9 DMPT3V9 DN PMID28048944-Compound-19 DMPT3V9 MI TTGWKQJ DMPT3V9 MN Rho-associated protein kinase 2 (ROCK2) DMPT3V9 MT DTT DMPT3V9 MA Inhibitor DMPT3V9 RN Rho kinase inhibitors: a patent review (2014 - 2016).Expert Opin Ther Pat. 2017 Apr;27(4):507-515. DMPT3V9 RU https://www.ncbi.nlm.nih.gov/pubmed/28048944 DM9ZXOP DI DM9ZXOP DM9ZXOP DN PMID28048944-Compound-2 DM9ZXOP MI TTZN7RP DM9ZXOP MN Rho-associated protein kinase 1 (ROCK1) DM9ZXOP MT DTT DM9ZXOP MA Inhibitor DM9ZXOP RN Rho kinase inhibitors: a patent review (2014 - 2016).Expert Opin Ther Pat. 2017 Apr;27(4):507-515. DM9ZXOP RU https://www.ncbi.nlm.nih.gov/pubmed/28048944 DM9ZXOP DI DM9ZXOP DM9ZXOP DN PMID28048944-Compound-2 DM9ZXOP MI TTGWKQJ DM9ZXOP MN Rho-associated protein kinase 2 (ROCK2) DM9ZXOP MT DTT DM9ZXOP MA Inhibitor DM9ZXOP RN Rho kinase inhibitors: a patent review (2014 - 2016).Expert Opin Ther Pat. 2017 Apr;27(4):507-515. DM9ZXOP RU https://www.ncbi.nlm.nih.gov/pubmed/28048944 DM19BQ6 DI DM19BQ6 DM19BQ6 DN PMID28048944-Compound-20 DM19BQ6 MI TTZN7RP DM19BQ6 MN Rho-associated protein kinase 1 (ROCK1) DM19BQ6 MT DTT DM19BQ6 MA Inhibitor DM19BQ6 RN Rho kinase inhibitors: a patent review (2014 - 2016).Expert Opin Ther Pat. 2017 Apr;27(4):507-515. DM19BQ6 RU https://www.ncbi.nlm.nih.gov/pubmed/28048944 DMPNG9C DI DMPNG9C DMPNG9C DN PMID28048944-Compound-21 DMPNG9C MI TTZN7RP DMPNG9C MN Rho-associated protein kinase 1 (ROCK1) DMPNG9C MT DTT DMPNG9C MA Inhibitor DMPNG9C RN Rho kinase inhibitors: a patent review (2014 - 2016).Expert Opin Ther Pat. 2017 Apr;27(4):507-515. DMPNG9C RU https://www.ncbi.nlm.nih.gov/pubmed/28048944 DM1BN74 DI DM1BN74 DM1BN74 DN PMID28048944-Compound-3 DM1BN74 MI TTZN7RP DM1BN74 MN Rho-associated protein kinase 1 (ROCK1) DM1BN74 MT DTT DM1BN74 MA Inhibitor DM1BN74 RN Rho kinase inhibitors: a patent review (2014 - 2016).Expert Opin Ther Pat. 2017 Apr;27(4):507-515. DM1BN74 RU https://www.ncbi.nlm.nih.gov/pubmed/28048944 DM1BN74 DI DM1BN74 DM1BN74 DN PMID28048944-Compound-3 DM1BN74 MI TTGWKQJ DM1BN74 MN Rho-associated protein kinase 2 (ROCK2) DM1BN74 MT DTT DM1BN74 MA Inhibitor DM1BN74 RN Rho kinase inhibitors: a patent review (2014 - 2016).Expert Opin Ther Pat. 2017 Apr;27(4):507-515. DM1BN74 RU https://www.ncbi.nlm.nih.gov/pubmed/28048944 DMJAUWG DI DMJAUWG DMJAUWG DN PMID28048944-Compound-4 DMJAUWG MI TTZN7RP DMJAUWG MN Rho-associated protein kinase 1 (ROCK1) DMJAUWG MT DTT DMJAUWG MA Inhibitor DMJAUWG RN Rho kinase inhibitors: a patent review (2014 - 2016).Expert Opin Ther Pat. 2017 Apr;27(4):507-515. DMJAUWG RU https://www.ncbi.nlm.nih.gov/pubmed/28048944 DMJAUWG DI DMJAUWG DMJAUWG DN PMID28048944-Compound-4 DMJAUWG MI TTGWKQJ DMJAUWG MN Rho-associated protein kinase 2 (ROCK2) DMJAUWG MT DTT DMJAUWG MA Inhibitor DMJAUWG RN Rho kinase inhibitors: a patent review (2014 - 2016).Expert Opin Ther Pat. 2017 Apr;27(4):507-515. DMJAUWG RU https://www.ncbi.nlm.nih.gov/pubmed/28048944 DMAB987 DI DMAB987 DMAB987 DN PMID28048944-Compound-5 DMAB987 MI TTZN7RP DMAB987 MN Rho-associated protein kinase 1 (ROCK1) DMAB987 MT DTT DMAB987 MA Inhibitor DMAB987 RN Rho kinase inhibitors: a patent review (2014 - 2016).Expert Opin Ther Pat. 2017 Apr;27(4):507-515. DMAB987 RU https://www.ncbi.nlm.nih.gov/pubmed/28048944 DMAB987 DI DMAB987 DMAB987 DN PMID28048944-Compound-5 DMAB987 MI TTGWKQJ DMAB987 MN Rho-associated protein kinase 2 (ROCK2) DMAB987 MT DTT DMAB987 MA Inhibitor DMAB987 RN Rho kinase inhibitors: a patent review (2014 - 2016).Expert Opin Ther Pat. 2017 Apr;27(4):507-515. DMAB987 RU https://www.ncbi.nlm.nih.gov/pubmed/28048944 DM5RCBV DI DM5RCBV DM5RCBV DN PMID28048944-Compound-6 DM5RCBV MI TTZN7RP DM5RCBV MN Rho-associated protein kinase 1 (ROCK1) DM5RCBV MT DTT DM5RCBV MA Inhibitor DM5RCBV RN Rho kinase inhibitors: a patent review (2014 - 2016).Expert Opin Ther Pat. 2017 Apr;27(4):507-515. DM5RCBV RU https://www.ncbi.nlm.nih.gov/pubmed/28048944 DM5RCBV DI DM5RCBV DM5RCBV DN PMID28048944-Compound-6 DM5RCBV MI TTGWKQJ DM5RCBV MN Rho-associated protein kinase 2 (ROCK2) DM5RCBV MT DTT DM5RCBV MA Inhibitor DM5RCBV RN Rho kinase inhibitors: a patent review (2014 - 2016).Expert Opin Ther Pat. 2017 Apr;27(4):507-515. DM5RCBV RU https://www.ncbi.nlm.nih.gov/pubmed/28048944 DMXZ368 DI DMXZ368 DMXZ368 DN PMID28048944-Compound-7 DMXZ368 MI TTZN7RP DMXZ368 MN Rho-associated protein kinase 1 (ROCK1) DMXZ368 MT DTT DMXZ368 MA Inhibitor DMXZ368 RN Rho kinase inhibitors: a patent review (2014 - 2016).Expert Opin Ther Pat. 2017 Apr;27(4):507-515. DMXZ368 RU https://www.ncbi.nlm.nih.gov/pubmed/28048944 DMXZ368 DI DMXZ368 DMXZ368 DN PMID28048944-Compound-7 DMXZ368 MI TTGWKQJ DMXZ368 MN Rho-associated protein kinase 2 (ROCK2) DMXZ368 MT DTT DMXZ368 MA Inhibitor DMXZ368 RN Rho kinase inhibitors: a patent review (2014 - 2016).Expert Opin Ther Pat. 2017 Apr;27(4):507-515. DMXZ368 RU https://www.ncbi.nlm.nih.gov/pubmed/28048944 DMRANS2 DI DMRANS2 DMRANS2 DN PMID28051882-Compound-Figure9 DMRANS2 MI TT9NXW4 DMRANS2 MN Sigma intracellular receptor 2 (TMEM97) DMRANS2 MT DTT DMRANS2 MA Ligand DMRANS2 RN Are sigma modulators an effective opportunity for cancer treatment A patent overview (1996-2016).Expert Opin Ther Pat. 2017 May;27(5):565-578. DMRANS2 RU https://www.ncbi.nlm.nih.gov/pubmed/28051882 DMLNA8P DI DMLNA8P DMLNA8P DN PMID28051882-Compound-XI DMLNA8P MI TT9NXW4 DMLNA8P MN Sigma intracellular receptor 2 (TMEM97) DMLNA8P MT DTT DMLNA8P MA Ligand DMLNA8P RN Are sigma modulators an effective opportunity for cancer treatment A patent overview (1996-2016).Expert Opin Ther Pat. 2017 May;27(5):565-578. DMLNA8P RU https://www.ncbi.nlm.nih.gov/pubmed/28051882 DM1RN89 DI DM1RN89 DM1RN89 DN PMID28051882-Compound-XIV DM1RN89 MI TT5TPI6 DM1RN89 MN Opioid receptor sigma 1 (OPRS1) DM1RN89 MT DTT DM1RN89 MA Ligand DM1RN89 RN Are sigma modulators an effective opportunity for cancer treatment A patent overview (1996-2016).Expert Opin Ther Pat. 2017 May;27(5):565-578. DM1RN89 RU https://www.ncbi.nlm.nih.gov/pubmed/28051882 DM1RN89 DI DM1RN89 DM1RN89 DN PMID28051882-Compound-XIV DM1RN89 MI TT9NXW4 DM1RN89 MN Sigma intracellular receptor 2 (TMEM97) DM1RN89 MT DTT DM1RN89 MA Ligand DM1RN89 RN Are sigma modulators an effective opportunity for cancer treatment A patent overview (1996-2016).Expert Opin Ther Pat. 2017 May;27(5):565-578. DM1RN89 RU https://www.ncbi.nlm.nih.gov/pubmed/28051882 DMG2PCZ DI DMG2PCZ DMG2PCZ DN PMID28067079-Compound-95 DMG2PCZ MI TTHS256 DMG2PCZ MN Metabotropic glutamate receptor 5 (mGluR5) DMG2PCZ MT DTT DMG2PCZ MA Modulator DMG2PCZ RN mGlu5 negative allosteric modulators: a patent review (2013 - 2016).Expert Opin Ther Pat. 2017 Jun;27(6):691-706. DMG2PCZ RU https://www.ncbi.nlm.nih.gov/pubmed/28067079 DMCUX42 DI DMCUX42 DMCUX42 DN PMID28067079-Compound-97 DMCUX42 MI TTHS256 DMCUX42 MN Metabotropic glutamate receptor 5 (mGluR5) DMCUX42 MT DTT DMCUX42 MA Modulator DMCUX42 RN mGlu5 negative allosteric modulators: a patent review (2013 - 2016).Expert Opin Ther Pat. 2017 Jun;27(6):691-706. DMCUX42 RU https://www.ncbi.nlm.nih.gov/pubmed/28067079 DMLKP1O DI DMLKP1O DMLKP1O DN PMID28067079-Compound-98 DMLKP1O MI TTHS256 DMLKP1O MN Metabotropic glutamate receptor 5 (mGluR5) DMLKP1O MT DTT DMLKP1O MA Modulator DMLKP1O RN mGlu5 negative allosteric modulators: a patent review (2013 - 2016).Expert Opin Ther Pat. 2017 Jun;27(6):691-706. DMLKP1O RU https://www.ncbi.nlm.nih.gov/pubmed/28067079 DMQW470 DI DMQW470 DMQW470 DN PMID28074661-Compound-US20100022547C80 DMQW470 MI TTL7C8Q DMQW470 MN Inosine-5'-monophosphate dehydrogenase 1 (IMPDH1) DMQW470 MT DTT DMQW470 MA Inhibitor DMQW470 RN Inosine-5'-monophosphate dehydrogenase (IMPDH) inhibitors: a patent and scientific literature review (2002-2016).Expert Opin Ther Pat. 2017 Jun;27(6):677-690. DMQW470 RU https://www.ncbi.nlm.nih.gov/pubmed/28074661 DMM9E1U DI DMM9E1U DMM9E1U DN PMID28074661-Compound-US20100022547C81 DMM9E1U MI TTL7C8Q DMM9E1U MN Inosine-5'-monophosphate dehydrogenase 1 (IMPDH1) DMM9E1U MT DTT DMM9E1U MA Inhibitor DMM9E1U RN Inosine-5'-monophosphate dehydrogenase (IMPDH) inhibitors: a patent and scientific literature review (2002-2016).Expert Opin Ther Pat. 2017 Jun;27(6):677-690. DMM9E1U RU https://www.ncbi.nlm.nih.gov/pubmed/28074661 DM94MT3 DI DM94MT3 DM94MT3 DN PMID28074661-Compound-US20100022547C82 DM94MT3 MI TTL7C8Q DM94MT3 MN Inosine-5'-monophosphate dehydrogenase 1 (IMPDH1) DM94MT3 MT DTT DM94MT3 MA Inhibitor DM94MT3 RN Inosine-5'-monophosphate dehydrogenase (IMPDH) inhibitors: a patent and scientific literature review (2002-2016).Expert Opin Ther Pat. 2017 Jun;27(6):677-690. DM94MT3 RU https://www.ncbi.nlm.nih.gov/pubmed/28074661 DM18LO7 DI DM18LO7 DM18LO7 DN PMID28074661-Compound-US20100022547C83 DM18LO7 MI TTL7C8Q DM18LO7 MN Inosine-5'-monophosphate dehydrogenase 1 (IMPDH1) DM18LO7 MT DTT DM18LO7 MA Inhibitor DM18LO7 RN Inosine-5'-monophosphate dehydrogenase (IMPDH) inhibitors: a patent and scientific literature review (2002-2016).Expert Opin Ther Pat. 2017 Jun;27(6):677-690. DM18LO7 RU https://www.ncbi.nlm.nih.gov/pubmed/28074661 DMONEJ4 DI DMONEJ4 DMONEJ4 DN PMID28074661-Compound-US20100022547C86 DMONEJ4 MI TTL7C8Q DMONEJ4 MN Inosine-5'-monophosphate dehydrogenase 1 (IMPDH1) DMONEJ4 MT DTT DMONEJ4 MA Inhibitor DMONEJ4 RN Inosine-5'-monophosphate dehydrogenase (IMPDH) inhibitors: a patent and scientific literature review (2002-2016).Expert Opin Ther Pat. 2017 Jun;27(6):677-690. DMONEJ4 RU https://www.ncbi.nlm.nih.gov/pubmed/28074661 DM8E702 DI DM8E702 DM8E702 DN PMID28074661-Compound-US20100022547C87 DM8E702 MI TTL7C8Q DM8E702 MN Inosine-5'-monophosphate dehydrogenase 1 (IMPDH1) DM8E702 MT DTT DM8E702 MA Inhibitor DM8E702 RN Inosine-5'-monophosphate dehydrogenase (IMPDH) inhibitors: a patent and scientific literature review (2002-2016).Expert Opin Ther Pat. 2017 Jun;27(6):677-690. DM8E702 RU https://www.ncbi.nlm.nih.gov/pubmed/28074661 DMNUR8E DI DMNUR8E DMNUR8E DN PMID28074661-Compound-US20100022547C88 DMNUR8E MI TTL7C8Q DMNUR8E MN Inosine-5'-monophosphate dehydrogenase 1 (IMPDH1) DMNUR8E MT DTT DMNUR8E MA Inhibitor DMNUR8E RN Inosine-5'-monophosphate dehydrogenase (IMPDH) inhibitors: a patent and scientific literature review (2002-2016).Expert Opin Ther Pat. 2017 Jun;27(6):677-690. DMNUR8E RU https://www.ncbi.nlm.nih.gov/pubmed/28074661 DM75QVW DI DM75QVW DM75QVW DN PMID28074661-Compound-US20120264760C80 DM75QVW MI TTL7C8Q DM75QVW MN Inosine-5'-monophosphate dehydrogenase 1 (IMPDH1) DM75QVW MT DTT DM75QVW MA Inhibitor DM75QVW RN Inosine-5'-monophosphate dehydrogenase (IMPDH) inhibitors: a patent and scientific literature review (2002-2016).Expert Opin Ther Pat. 2017 Jun;27(6):677-690. DM75QVW RU https://www.ncbi.nlm.nih.gov/pubmed/28074661 DMH249S DI DMH249S DMH249S DN PMID28074661-Compound-US20120264760C81 DMH249S MI TTL7C8Q DMH249S MN Inosine-5'-monophosphate dehydrogenase 1 (IMPDH1) DMH249S MT DTT DMH249S MA Inhibitor DMH249S RN Inosine-5'-monophosphate dehydrogenase (IMPDH) inhibitors: a patent and scientific literature review (2002-2016).Expert Opin Ther Pat. 2017 Jun;27(6):677-690. DMH249S RU https://www.ncbi.nlm.nih.gov/pubmed/28074661 DM18PRU DI DM18PRU DM18PRU DN PMID28074661-Compound-US20120264760C82 DM18PRU MI TTL7C8Q DM18PRU MN Inosine-5'-monophosphate dehydrogenase 1 (IMPDH1) DM18PRU MT DTT DM18PRU MA Inhibitor DM18PRU RN Inosine-5'-monophosphate dehydrogenase (IMPDH) inhibitors: a patent and scientific literature review (2002-2016).Expert Opin Ther Pat. 2017 Jun;27(6):677-690. DM18PRU RU https://www.ncbi.nlm.nih.gov/pubmed/28074661 DMD7AU3 DI DMD7AU3 DMD7AU3 DN PMID28074661-Compound-US20120264760C83 DMD7AU3 MI TTL7C8Q DMD7AU3 MN Inosine-5'-monophosphate dehydrogenase 1 (IMPDH1) DMD7AU3 MT DTT DMD7AU3 MA Inhibitor DMD7AU3 RN Inosine-5'-monophosphate dehydrogenase (IMPDH) inhibitors: a patent and scientific literature review (2002-2016).Expert Opin Ther Pat. 2017 Jun;27(6):677-690. DMD7AU3 RU https://www.ncbi.nlm.nih.gov/pubmed/28074661 DMKFEO4 DI DMKFEO4 DMKFEO4 DN PMID28074661-Compound-US20120264760C86 DMKFEO4 MI TTL7C8Q DMKFEO4 MN Inosine-5'-monophosphate dehydrogenase 1 (IMPDH1) DMKFEO4 MT DTT DMKFEO4 MA Inhibitor DMKFEO4 RN Inosine-5'-monophosphate dehydrogenase (IMPDH) inhibitors: a patent and scientific literature review (2002-2016).Expert Opin Ther Pat. 2017 Jun;27(6):677-690. DMKFEO4 RU https://www.ncbi.nlm.nih.gov/pubmed/28074661 DM85XKT DI DM85XKT DM85XKT DN PMID28074661-Compound-US20120264760C87 DM85XKT MI TTL7C8Q DM85XKT MN Inosine-5'-monophosphate dehydrogenase 1 (IMPDH1) DM85XKT MT DTT DM85XKT MA Inhibitor DM85XKT RN Inosine-5'-monophosphate dehydrogenase (IMPDH) inhibitors: a patent and scientific literature review (2002-2016).Expert Opin Ther Pat. 2017 Jun;27(6):677-690. DM85XKT RU https://www.ncbi.nlm.nih.gov/pubmed/28074661 DMIKRCM DI DMIKRCM DMIKRCM DN PMID28074661-Compound-US20120264760C88 DMIKRCM MI TTL7C8Q DMIKRCM MN Inosine-5'-monophosphate dehydrogenase 1 (IMPDH1) DMIKRCM MT DTT DMIKRCM MA Inhibitor DMIKRCM RN Inosine-5'-monophosphate dehydrogenase (IMPDH) inhibitors: a patent and scientific literature review (2002-2016).Expert Opin Ther Pat. 2017 Jun;27(6):677-690. DMIKRCM RU https://www.ncbi.nlm.nih.gov/pubmed/28074661 DMEJ4LW DI DMEJ4LW DMEJ4LW DN PMID28074661-Compound-US20128202889C90 DMEJ4LW MI TTL7C8Q DMEJ4LW MN Inosine-5'-monophosphate dehydrogenase 1 (IMPDH1) DMEJ4LW MT DTT DMEJ4LW MA Inhibitor DMEJ4LW RN Inosine-5'-monophosphate dehydrogenase (IMPDH) inhibitors: a patent and scientific literature review (2002-2016).Expert Opin Ther Pat. 2017 Jun;27(6):677-690. DMEJ4LW RU https://www.ncbi.nlm.nih.gov/pubmed/28074661 DM1QUN0 DI DM1QUN0 DM1QUN0 DN PMID28074661-Compound-US20158969342C84 DM1QUN0 MI TTL7C8Q DM1QUN0 MN Inosine-5'-monophosphate dehydrogenase 1 (IMPDH1) DM1QUN0 MT DTT DM1QUN0 MA Inhibitor DM1QUN0 RN Inosine-5'-monophosphate dehydrogenase (IMPDH) inhibitors: a patent and scientific literature review (2002-2016).Expert Opin Ther Pat. 2017 Jun;27(6):677-690. DM1QUN0 RU https://www.ncbi.nlm.nih.gov/pubmed/28074661 DMMYH82 DI DMMYH82 DMMYH82 DN PMID28074661-Compound-US20169447134C85 DMMYH82 MI TTL7C8Q DMMYH82 MN Inosine-5'-monophosphate dehydrogenase 1 (IMPDH1) DMMYH82 MT DTT DMMYH82 MA Inhibitor DMMYH82 RN Inosine-5'-monophosphate dehydrogenase (IMPDH) inhibitors: a patent and scientific literature review (2002-2016).Expert Opin Ther Pat. 2017 Jun;27(6):677-690. DMMYH82 RU https://www.ncbi.nlm.nih.gov/pubmed/28074661 DMFORUW DI DMFORUW DMFORUW DN PMID28074661-Compound-WO2009018344C78 DMFORUW MI TTL7C8Q DMFORUW MN Inosine-5'-monophosphate dehydrogenase 1 (IMPDH1) DMFORUW MT DTT DMFORUW MA Inhibitor DMFORUW RN Inosine-5'-monophosphate dehydrogenase (IMPDH) inhibitors: a patent and scientific literature review (2002-2016).Expert Opin Ther Pat. 2017 Jun;27(6):677-690. DMFORUW RU https://www.ncbi.nlm.nih.gov/pubmed/28074661 DM64QNL DI DM64QNL DM64QNL DN PMID28074661-Compound-WO2009018344C79 DM64QNL MI TTL7C8Q DM64QNL MN Inosine-5'-monophosphate dehydrogenase 1 (IMPDH1) DM64QNL MT DTT DM64QNL MA Inhibitor DM64QNL RN Inosine-5'-monophosphate dehydrogenase (IMPDH) inhibitors: a patent and scientific literature review (2002-2016).Expert Opin Ther Pat. 2017 Jun;27(6):677-690. DM64QNL RU https://www.ncbi.nlm.nih.gov/pubmed/28074661 DMC4TQL DI DMC4TQL DMC4TQL DN PMID28092474-Compound-32 DMC4TQL MI TTBH0VX DMC4TQL MN Histone deacetylase (HDAC) DMC4TQL MT DTT DMC4TQL MA Inhibitor DMC4TQL RN Novel histone deacetylase 6 (HDAC6) selective inhibitors: a patent evaluation (WO2014181137).Expert Opin Ther Pat. 2017 Mar;27(3):229-236. DMC4TQL RU https://www.ncbi.nlm.nih.gov/pubmed/28092474 DMGZ61E DI DMGZ61E DMGZ61E DN PMID28092474-Compound-32a DMGZ61E MI TT6R7JZ DMGZ61E MN Histone deacetylase 1 (HDAC1) DMGZ61E MT DTT DMGZ61E MA Inhibitor DMGZ61E RN Novel histone deacetylase 6 (HDAC6) selective inhibitors: a patent evaluation (WO2014181137).Expert Opin Ther Pat. 2017 Mar;27(3):229-236. DMGZ61E RU https://www.ncbi.nlm.nih.gov/pubmed/28092474 DMGZ61E DI DMGZ61E DMGZ61E DN PMID28092474-Compound-32a DMGZ61E MI TT5ZKDI DMGZ61E MN Histone deacetylase 6 (HDAC6) DMGZ61E MT DTT DMGZ61E MA Inhibitor DMGZ61E RN Novel histone deacetylase 6 (HDAC6) selective inhibitors: a patent evaluation (WO2014181137).Expert Opin Ther Pat. 2017 Mar;27(3):229-236. DMGZ61E RU https://www.ncbi.nlm.nih.gov/pubmed/28092474 DMT2B5A DI DMT2B5A DMT2B5A DN PMID28092474-Compound-32b DMT2B5A MI TT6R7JZ DMT2B5A MN Histone deacetylase 1 (HDAC1) DMT2B5A MT DTT DMT2B5A MA Inhibitor DMT2B5A RN Novel histone deacetylase 6 (HDAC6) selective inhibitors: a patent evaluation (WO2014181137).Expert Opin Ther Pat. 2017 Mar;27(3):229-236. DMT2B5A RU https://www.ncbi.nlm.nih.gov/pubmed/28092474 DMT2B5A DI DMT2B5A DMT2B5A DN PMID28092474-Compound-32b DMT2B5A MI TT5ZKDI DMT2B5A MN Histone deacetylase 6 (HDAC6) DMT2B5A MT DTT DMT2B5A MA Inhibitor DMT2B5A RN Novel histone deacetylase 6 (HDAC6) selective inhibitors: a patent evaluation (WO2014181137).Expert Opin Ther Pat. 2017 Mar;27(3):229-236. DMT2B5A RU https://www.ncbi.nlm.nih.gov/pubmed/28092474 DMGA3XL DI DMGA3XL DMGA3XL DN PMID28092474-Compound-32c DMGA3XL MI TT6R7JZ DMGA3XL MN Histone deacetylase 1 (HDAC1) DMGA3XL MT DTT DMGA3XL MA Inhibitor DMGA3XL RN Novel histone deacetylase 6 (HDAC6) selective inhibitors: a patent evaluation (WO2014181137).Expert Opin Ther Pat. 2017 Mar;27(3):229-236. DMGA3XL RU https://www.ncbi.nlm.nih.gov/pubmed/28092474 DMGA3XL DI DMGA3XL DMGA3XL DN PMID28092474-Compound-32c DMGA3XL MI TT5ZKDI DMGA3XL MN Histone deacetylase 6 (HDAC6) DMGA3XL MT DTT DMGA3XL MA Inhibitor DMGA3XL RN Novel histone deacetylase 6 (HDAC6) selective inhibitors: a patent evaluation (WO2014181137).Expert Opin Ther Pat. 2017 Mar;27(3):229-236. DMGA3XL RU https://www.ncbi.nlm.nih.gov/pubmed/28092474 DMW21U4 DI DMW21U4 DMW21U4 DN PMID28092474-Compound-32d DMW21U4 MI TT6R7JZ DMW21U4 MN Histone deacetylase 1 (HDAC1) DMW21U4 MT DTT DMW21U4 MA Inhibitor DMW21U4 RN Novel histone deacetylase 6 (HDAC6) selective inhibitors: a patent evaluation (WO2014181137).Expert Opin Ther Pat. 2017 Mar;27(3):229-236. DMW21U4 RU https://www.ncbi.nlm.nih.gov/pubmed/28092474 DMW21U4 DI DMW21U4 DMW21U4 DN PMID28092474-Compound-32d DMW21U4 MI TT5ZKDI DMW21U4 MN Histone deacetylase 6 (HDAC6) DMW21U4 MT DTT DMW21U4 MA Inhibitor DMW21U4 RN Novel histone deacetylase 6 (HDAC6) selective inhibitors: a patent evaluation (WO2014181137).Expert Opin Ther Pat. 2017 Mar;27(3):229-236. DMW21U4 RU https://www.ncbi.nlm.nih.gov/pubmed/28092474 DM8NHQS DI DM8NHQS DM8NHQS DN PMID28092474-Compound-32e DM8NHQS MI TT6R7JZ DM8NHQS MN Histone deacetylase 1 (HDAC1) DM8NHQS MT DTT DM8NHQS MA Inhibitor DM8NHQS RN Novel histone deacetylase 6 (HDAC6) selective inhibitors: a patent evaluation (WO2014181137).Expert Opin Ther Pat. 2017 Mar;27(3):229-236. DM8NHQS RU https://www.ncbi.nlm.nih.gov/pubmed/28092474 DM8NHQS DI DM8NHQS DM8NHQS DN PMID28092474-Compound-32e DM8NHQS MI TT5ZKDI DM8NHQS MN Histone deacetylase 6 (HDAC6) DM8NHQS MT DTT DM8NHQS MA Inhibitor DM8NHQS RN Novel histone deacetylase 6 (HDAC6) selective inhibitors: a patent evaluation (WO2014181137).Expert Opin Ther Pat. 2017 Mar;27(3):229-236. DM8NHQS RU https://www.ncbi.nlm.nih.gov/pubmed/28092474 DMEIZ6Y DI DMEIZ6Y DMEIZ6Y DN PMID28092474-Compound-32f DMEIZ6Y MI TT6R7JZ DMEIZ6Y MN Histone deacetylase 1 (HDAC1) DMEIZ6Y MT DTT DMEIZ6Y MA Inhibitor DMEIZ6Y RN Novel histone deacetylase 6 (HDAC6) selective inhibitors: a patent evaluation (WO2014181137).Expert Opin Ther Pat. 2017 Mar;27(3):229-236. DMEIZ6Y RU https://www.ncbi.nlm.nih.gov/pubmed/28092474 DMEIZ6Y DI DMEIZ6Y DMEIZ6Y DN PMID28092474-Compound-32f DMEIZ6Y MI TT5ZKDI DMEIZ6Y MN Histone deacetylase 6 (HDAC6) DMEIZ6Y MT DTT DMEIZ6Y MA Inhibitor DMEIZ6Y RN Novel histone deacetylase 6 (HDAC6) selective inhibitors: a patent evaluation (WO2014181137).Expert Opin Ther Pat. 2017 Mar;27(3):229-236. DMEIZ6Y RU https://www.ncbi.nlm.nih.gov/pubmed/28092474 DMTKLEP DI DMTKLEP DMTKLEP DN PMID28092474-Compound-32g DMTKLEP MI TT6R7JZ DMTKLEP MN Histone deacetylase 1 (HDAC1) DMTKLEP MT DTT DMTKLEP MA Inhibitor DMTKLEP RN Novel histone deacetylase 6 (HDAC6) selective inhibitors: a patent evaluation (WO2014181137).Expert Opin Ther Pat. 2017 Mar;27(3):229-236. DMTKLEP RU https://www.ncbi.nlm.nih.gov/pubmed/28092474 DMTKLEP DI DMTKLEP DMTKLEP DN PMID28092474-Compound-32g DMTKLEP MI TT5ZKDI DMTKLEP MN Histone deacetylase 6 (HDAC6) DMTKLEP MT DTT DMTKLEP MA Inhibitor DMTKLEP RN Novel histone deacetylase 6 (HDAC6) selective inhibitors: a patent evaluation (WO2014181137).Expert Opin Ther Pat. 2017 Mar;27(3):229-236. DMTKLEP RU https://www.ncbi.nlm.nih.gov/pubmed/28092474 DME1WHT DI DME1WHT DME1WHT DN PMID28092474-Compound-32h DME1WHT MI TT6R7JZ DME1WHT MN Histone deacetylase 1 (HDAC1) DME1WHT MT DTT DME1WHT MA Inhibitor DME1WHT RN Novel histone deacetylase 6 (HDAC6) selective inhibitors: a patent evaluation (WO2014181137).Expert Opin Ther Pat. 2017 Mar;27(3):229-236. DME1WHT RU https://www.ncbi.nlm.nih.gov/pubmed/28092474 DME1WHT DI DME1WHT DME1WHT DN PMID28092474-Compound-32h DME1WHT MI TT5ZKDI DME1WHT MN Histone deacetylase 6 (HDAC6) DME1WHT MT DTT DME1WHT MA Inhibitor DME1WHT RN Novel histone deacetylase 6 (HDAC6) selective inhibitors: a patent evaluation (WO2014181137).Expert Opin Ther Pat. 2017 Mar;27(3):229-236. DME1WHT RU https://www.ncbi.nlm.nih.gov/pubmed/28092474 DMN3ZEF DI DMN3ZEF DMN3ZEF DN PMID28092474-Compound-32i DMN3ZEF MI TT6R7JZ DMN3ZEF MN Histone deacetylase 1 (HDAC1) DMN3ZEF MT DTT DMN3ZEF MA Inhibitor DMN3ZEF RN Novel histone deacetylase 6 (HDAC6) selective inhibitors: a patent evaluation (WO2014181137).Expert Opin Ther Pat. 2017 Mar;27(3):229-236. DMN3ZEF RU https://www.ncbi.nlm.nih.gov/pubmed/28092474 DMN3ZEF DI DMN3ZEF DMN3ZEF DN PMID28092474-Compound-32i DMN3ZEF MI TT5ZKDI DMN3ZEF MN Histone deacetylase 6 (HDAC6) DMN3ZEF MT DTT DMN3ZEF MA Inhibitor DMN3ZEF RN Novel histone deacetylase 6 (HDAC6) selective inhibitors: a patent evaluation (WO2014181137).Expert Opin Ther Pat. 2017 Mar;27(3):229-236. DMN3ZEF RU https://www.ncbi.nlm.nih.gov/pubmed/28092474 DMSGWTX DI DMSGWTX DMSGWTX DN PMID28092474-Compound-32j DMSGWTX MI TT6R7JZ DMSGWTX MN Histone deacetylase 1 (HDAC1) DMSGWTX MT DTT DMSGWTX MA Inhibitor DMSGWTX RN Novel histone deacetylase 6 (HDAC6) selective inhibitors: a patent evaluation (WO2014181137).Expert Opin Ther Pat. 2017 Mar;27(3):229-236. DMSGWTX RU https://www.ncbi.nlm.nih.gov/pubmed/28092474 DMSGWTX DI DMSGWTX DMSGWTX DN PMID28092474-Compound-32j DMSGWTX MI TT5ZKDI DMSGWTX MN Histone deacetylase 6 (HDAC6) DMSGWTX MT DTT DMSGWTX MA Inhibitor DMSGWTX RN Novel histone deacetylase 6 (HDAC6) selective inhibitors: a patent evaluation (WO2014181137).Expert Opin Ther Pat. 2017 Mar;27(3):229-236. DMSGWTX RU https://www.ncbi.nlm.nih.gov/pubmed/28092474 DMHSJ65 DI DMHSJ65 DMHSJ65 DN PMID28092474-Compound-32k DMHSJ65 MI TT6R7JZ DMHSJ65 MN Histone deacetylase 1 (HDAC1) DMHSJ65 MT DTT DMHSJ65 MA Inhibitor DMHSJ65 RN Novel histone deacetylase 6 (HDAC6) selective inhibitors: a patent evaluation (WO2014181137).Expert Opin Ther Pat. 2017 Mar;27(3):229-236. DMHSJ65 RU https://www.ncbi.nlm.nih.gov/pubmed/28092474 DMHSJ65 DI DMHSJ65 DMHSJ65 DN PMID28092474-Compound-32k DMHSJ65 MI TT5ZKDI DMHSJ65 MN Histone deacetylase 6 (HDAC6) DMHSJ65 MT DTT DMHSJ65 MA Inhibitor DMHSJ65 RN Novel histone deacetylase 6 (HDAC6) selective inhibitors: a patent evaluation (WO2014181137).Expert Opin Ther Pat. 2017 Mar;27(3):229-236. DMHSJ65 RU https://www.ncbi.nlm.nih.gov/pubmed/28092474 DMSP5IA DI DMSP5IA DMSP5IA DN PMID28092474-Compound-32l DMSP5IA MI TT6R7JZ DMSP5IA MN Histone deacetylase 1 (HDAC1) DMSP5IA MT DTT DMSP5IA MA Inhibitor DMSP5IA RN Novel histone deacetylase 6 (HDAC6) selective inhibitors: a patent evaluation (WO2014181137).Expert Opin Ther Pat. 2017 Mar;27(3):229-236. DMSP5IA RU https://www.ncbi.nlm.nih.gov/pubmed/28092474 DMSP5IA DI DMSP5IA DMSP5IA DN PMID28092474-Compound-32l DMSP5IA MI TT5ZKDI DMSP5IA MN Histone deacetylase 6 (HDAC6) DMSP5IA MT DTT DMSP5IA MA Inhibitor DMSP5IA RN Novel histone deacetylase 6 (HDAC6) selective inhibitors: a patent evaluation (WO2014181137).Expert Opin Ther Pat. 2017 Mar;27(3):229-236. DMSP5IA RU https://www.ncbi.nlm.nih.gov/pubmed/28092474 DMADMWB DI DMADMWB DMADMWB DN PMID28092474-Compound-32m DMADMWB MI TT6R7JZ DMADMWB MN Histone deacetylase 1 (HDAC1) DMADMWB MT DTT DMADMWB MA Inhibitor DMADMWB RN Novel histone deacetylase 6 (HDAC6) selective inhibitors: a patent evaluation (WO2014181137).Expert Opin Ther Pat. 2017 Mar;27(3):229-236. DMADMWB RU https://www.ncbi.nlm.nih.gov/pubmed/28092474 DMADMWB DI DMADMWB DMADMWB DN PMID28092474-Compound-32m DMADMWB MI TT5ZKDI DMADMWB MN Histone deacetylase 6 (HDAC6) DMADMWB MT DTT DMADMWB MA Inhibitor DMADMWB RN Novel histone deacetylase 6 (HDAC6) selective inhibitors: a patent evaluation (WO2014181137).Expert Opin Ther Pat. 2017 Mar;27(3):229-236. DMADMWB RU https://www.ncbi.nlm.nih.gov/pubmed/28092474 DMJO3RW DI DMJO3RW DMJO3RW DN PMID28092474-Compound-32n DMJO3RW MI TT6R7JZ DMJO3RW MN Histone deacetylase 1 (HDAC1) DMJO3RW MT DTT DMJO3RW MA Inhibitor DMJO3RW RN Novel histone deacetylase 6 (HDAC6) selective inhibitors: a patent evaluation (WO2014181137).Expert Opin Ther Pat. 2017 Mar;27(3):229-236. DMJO3RW RU https://www.ncbi.nlm.nih.gov/pubmed/28092474 DMJO3RW DI DMJO3RW DMJO3RW DN PMID28092474-Compound-32n DMJO3RW MI TT5ZKDI DMJO3RW MN Histone deacetylase 6 (HDAC6) DMJO3RW MT DTT DMJO3RW MA Inhibitor DMJO3RW RN Novel histone deacetylase 6 (HDAC6) selective inhibitors: a patent evaluation (WO2014181137).Expert Opin Ther Pat. 2017 Mar;27(3):229-236. DMJO3RW RU https://www.ncbi.nlm.nih.gov/pubmed/28092474 DMV9BQN DI DMV9BQN DMV9BQN DN PMID28092474-Compound-32o DMV9BQN MI TT6R7JZ DMV9BQN MN Histone deacetylase 1 (HDAC1) DMV9BQN MT DTT DMV9BQN MA Inhibitor DMV9BQN RN Novel histone deacetylase 6 (HDAC6) selective inhibitors: a patent evaluation (WO2014181137).Expert Opin Ther Pat. 2017 Mar;27(3):229-236. DMV9BQN RU https://www.ncbi.nlm.nih.gov/pubmed/28092474 DMV9BQN DI DMV9BQN DMV9BQN DN PMID28092474-Compound-32o DMV9BQN MI TT5ZKDI DMV9BQN MN Histone deacetylase 6 (HDAC6) DMV9BQN MT DTT DMV9BQN MA Inhibitor DMV9BQN RN Novel histone deacetylase 6 (HDAC6) selective inhibitors: a patent evaluation (WO2014181137).Expert Opin Ther Pat. 2017 Mar;27(3):229-236. DMV9BQN RU https://www.ncbi.nlm.nih.gov/pubmed/28092474 DM4ZO21 DI DM4ZO21 DM4ZO21 DN PMID28092474-Compound-32p DM4ZO21 MI TT6R7JZ DM4ZO21 MN Histone deacetylase 1 (HDAC1) DM4ZO21 MT DTT DM4ZO21 MA Inhibitor DM4ZO21 RN Novel histone deacetylase 6 (HDAC6) selective inhibitors: a patent evaluation (WO2014181137).Expert Opin Ther Pat. 2017 Mar;27(3):229-236. DM4ZO21 RU https://www.ncbi.nlm.nih.gov/pubmed/28092474 DM4ZO21 DI DM4ZO21 DM4ZO21 DN PMID28092474-Compound-32p DM4ZO21 MI TT5ZKDI DM4ZO21 MN Histone deacetylase 6 (HDAC6) DM4ZO21 MT DTT DM4ZO21 MA Inhibitor DM4ZO21 RN Novel histone deacetylase 6 (HDAC6) selective inhibitors: a patent evaluation (WO2014181137).Expert Opin Ther Pat. 2017 Mar;27(3):229-236. DM4ZO21 RU https://www.ncbi.nlm.nih.gov/pubmed/28092474 DMEASZY DI DMEASZY DMEASZY DN PMID28092474-Compound-32q DMEASZY MI TT6R7JZ DMEASZY MN Histone deacetylase 1 (HDAC1) DMEASZY MT DTT DMEASZY MA Inhibitor DMEASZY RN Novel histone deacetylase 6 (HDAC6) selective inhibitors: a patent evaluation (WO2014181137).Expert Opin Ther Pat. 2017 Mar;27(3):229-236. DMEASZY RU https://www.ncbi.nlm.nih.gov/pubmed/28092474 DMEASZY DI DMEASZY DMEASZY DN PMID28092474-Compound-32q DMEASZY MI TT5ZKDI DMEASZY MN Histone deacetylase 6 (HDAC6) DMEASZY MT DTT DMEASZY MA Inhibitor DMEASZY RN Novel histone deacetylase 6 (HDAC6) selective inhibitors: a patent evaluation (WO2014181137).Expert Opin Ther Pat. 2017 Mar;27(3):229-236. DMEASZY RU https://www.ncbi.nlm.nih.gov/pubmed/28092474 DMLTKMS DI DMLTKMS DMLTKMS DN PMID28092474-Compound-32r DMLTKMS MI TT6R7JZ DMLTKMS MN Histone deacetylase 1 (HDAC1) DMLTKMS MT DTT DMLTKMS MA Inhibitor DMLTKMS RN Novel histone deacetylase 6 (HDAC6) selective inhibitors: a patent evaluation (WO2014181137).Expert Opin Ther Pat. 2017 Mar;27(3):229-236. DMLTKMS RU https://www.ncbi.nlm.nih.gov/pubmed/28092474 DMLTKMS DI DMLTKMS DMLTKMS DN PMID28092474-Compound-32r DMLTKMS MI TT5ZKDI DMLTKMS MN Histone deacetylase 6 (HDAC6) DMLTKMS MT DTT DMLTKMS MA Inhibitor DMLTKMS RN Novel histone deacetylase 6 (HDAC6) selective inhibitors: a patent evaluation (WO2014181137).Expert Opin Ther Pat. 2017 Mar;27(3):229-236. DMLTKMS RU https://www.ncbi.nlm.nih.gov/pubmed/28092474 DMS103B DI DMS103B DMS103B DN PMID28092474-Compound-32s DMS103B MI TT6R7JZ DMS103B MN Histone deacetylase 1 (HDAC1) DMS103B MT DTT DMS103B MA Inhibitor DMS103B RN Novel histone deacetylase 6 (HDAC6) selective inhibitors: a patent evaluation (WO2014181137).Expert Opin Ther Pat. 2017 Mar;27(3):229-236. DMS103B RU https://www.ncbi.nlm.nih.gov/pubmed/28092474 DMS103B DI DMS103B DMS103B DN PMID28092474-Compound-32s DMS103B MI TT5ZKDI DMS103B MN Histone deacetylase 6 (HDAC6) DMS103B MT DTT DMS103B MA Inhibitor DMS103B RN Novel histone deacetylase 6 (HDAC6) selective inhibitors: a patent evaluation (WO2014181137).Expert Opin Ther Pat. 2017 Mar;27(3):229-236. DMS103B RU https://www.ncbi.nlm.nih.gov/pubmed/28092474 DM2JF0T DI DM2JF0T DM2JF0T DN PMID28092474-Compound-32t DM2JF0T MI TT6R7JZ DM2JF0T MN Histone deacetylase 1 (HDAC1) DM2JF0T MT DTT DM2JF0T MA Inhibitor DM2JF0T RN Novel histone deacetylase 6 (HDAC6) selective inhibitors: a patent evaluation (WO2014181137).Expert Opin Ther Pat. 2017 Mar;27(3):229-236. DM2JF0T RU https://www.ncbi.nlm.nih.gov/pubmed/28092474 DM2JF0T DI DM2JF0T DM2JF0T DN PMID28092474-Compound-32t DM2JF0T MI TT5ZKDI DM2JF0T MN Histone deacetylase 6 (HDAC6) DM2JF0T MT DTT DM2JF0T MA Inhibitor DM2JF0T RN Novel histone deacetylase 6 (HDAC6) selective inhibitors: a patent evaluation (WO2014181137).Expert Opin Ther Pat. 2017 Mar;27(3):229-236. DM2JF0T RU https://www.ncbi.nlm.nih.gov/pubmed/28092474 DM805ZN DI DM805ZN DM805ZN DN PMID28092474-Compound-32u DM805ZN MI TT6R7JZ DM805ZN MN Histone deacetylase 1 (HDAC1) DM805ZN MT DTT DM805ZN MA Inhibitor DM805ZN RN Novel histone deacetylase 6 (HDAC6) selective inhibitors: a patent evaluation (WO2014181137).Expert Opin Ther Pat. 2017 Mar;27(3):229-236. DM805ZN RU https://www.ncbi.nlm.nih.gov/pubmed/28092474 DM805ZN DI DM805ZN DM805ZN DN PMID28092474-Compound-32u DM805ZN MI TT5ZKDI DM805ZN MN Histone deacetylase 6 (HDAC6) DM805ZN MT DTT DM805ZN MA Inhibitor DM805ZN RN Novel histone deacetylase 6 (HDAC6) selective inhibitors: a patent evaluation (WO2014181137).Expert Opin Ther Pat. 2017 Mar;27(3):229-236. DM805ZN RU https://www.ncbi.nlm.nih.gov/pubmed/28092474 DMHV3ES DI DMHV3ES DMHV3ES DN PMID28092474-Compound-32v DMHV3ES MI TT6R7JZ DMHV3ES MN Histone deacetylase 1 (HDAC1) DMHV3ES MT DTT DMHV3ES MA Inhibitor DMHV3ES RN Novel histone deacetylase 6 (HDAC6) selective inhibitors: a patent evaluation (WO2014181137).Expert Opin Ther Pat. 2017 Mar;27(3):229-236. DMHV3ES RU https://www.ncbi.nlm.nih.gov/pubmed/28092474 DMHV3ES DI DMHV3ES DMHV3ES DN PMID28092474-Compound-32v DMHV3ES MI TT5ZKDI DMHV3ES MN Histone deacetylase 6 (HDAC6) DMHV3ES MT DTT DMHV3ES MA Inhibitor DMHV3ES RN Novel histone deacetylase 6 (HDAC6) selective inhibitors: a patent evaluation (WO2014181137).Expert Opin Ther Pat. 2017 Mar;27(3):229-236. DMHV3ES RU https://www.ncbi.nlm.nih.gov/pubmed/28092474 DML79XQ DI DML79XQ DML79XQ DN PMID28092474-Compound-32x DML79XQ MI TT6R7JZ DML79XQ MN Histone deacetylase 1 (HDAC1) DML79XQ MT DTT DML79XQ MA Inhibitor DML79XQ RN Novel histone deacetylase 6 (HDAC6) selective inhibitors: a patent evaluation (WO2014181137).Expert Opin Ther Pat. 2017 Mar;27(3):229-236. DML79XQ RU https://www.ncbi.nlm.nih.gov/pubmed/28092474 DML79XQ DI DML79XQ DML79XQ DN PMID28092474-Compound-32x DML79XQ MI TT5ZKDI DML79XQ MN Histone deacetylase 6 (HDAC6) DML79XQ MT DTT DML79XQ MA Inhibitor DML79XQ RN Novel histone deacetylase 6 (HDAC6) selective inhibitors: a patent evaluation (WO2014181137).Expert Opin Ther Pat. 2017 Mar;27(3):229-236. DML79XQ RU https://www.ncbi.nlm.nih.gov/pubmed/28092474 DMLR03U DI DMLR03U DMLR03U DN PMID28092474-Compound-32y DMLR03U MI TT6R7JZ DMLR03U MN Histone deacetylase 1 (HDAC1) DMLR03U MT DTT DMLR03U MA Inhibitor DMLR03U RN Novel histone deacetylase 6 (HDAC6) selective inhibitors: a patent evaluation (WO2014181137).Expert Opin Ther Pat. 2017 Mar;27(3):229-236. DMLR03U RU https://www.ncbi.nlm.nih.gov/pubmed/28092474 DMLR03U DI DMLR03U DMLR03U DN PMID28092474-Compound-32y DMLR03U MI TT5ZKDI DMLR03U MN Histone deacetylase 6 (HDAC6) DMLR03U MT DTT DMLR03U MA Inhibitor DMLR03U RN Novel histone deacetylase 6 (HDAC6) selective inhibitors: a patent evaluation (WO2014181137).Expert Opin Ther Pat. 2017 Mar;27(3):229-236. DMLR03U RU https://www.ncbi.nlm.nih.gov/pubmed/28092474 DMEPWGH DI DMEPWGH DMEPWGH DN PMID28092474-Compound-32z DMEPWGH MI TT6R7JZ DMEPWGH MN Histone deacetylase 1 (HDAC1) DMEPWGH MT DTT DMEPWGH MA Inhibitor DMEPWGH RN Novel histone deacetylase 6 (HDAC6) selective inhibitors: a patent evaluation (WO2014181137).Expert Opin Ther Pat. 2017 Mar;27(3):229-236. DMEPWGH RU https://www.ncbi.nlm.nih.gov/pubmed/28092474 DMEPWGH DI DMEPWGH DMEPWGH DN PMID28092474-Compound-32z DMEPWGH MI TT5ZKDI DMEPWGH MN Histone deacetylase 6 (HDAC6) DMEPWGH MT DTT DMEPWGH MA Inhibitor DMEPWGH RN Novel histone deacetylase 6 (HDAC6) selective inhibitors: a patent evaluation (WO2014181137).Expert Opin Ther Pat. 2017 Mar;27(3):229-236. DMEPWGH RU https://www.ncbi.nlm.nih.gov/pubmed/28092474 DMRE6GP DI DMRE6GP DMRE6GP DN PMID28092474-Compound-33 DMRE6GP MI TTBH0VX DMRE6GP MN Histone deacetylase (HDAC) DMRE6GP MT DTT DMRE6GP MA Inhibitor DMRE6GP RN Novel histone deacetylase 6 (HDAC6) selective inhibitors: a patent evaluation (WO2014181137).Expert Opin Ther Pat. 2017 Mar;27(3):229-236. DMRE6GP RU https://www.ncbi.nlm.nih.gov/pubmed/28092474 DM7GH4Y DI DM7GH4Y DM7GH4Y DN PMID28092474-Compound-33a DM7GH4Y MI TT6R7JZ DM7GH4Y MN Histone deacetylase 1 (HDAC1) DM7GH4Y MT DTT DM7GH4Y MA Inhibitor DM7GH4Y RN Novel histone deacetylase 6 (HDAC6) selective inhibitors: a patent evaluation (WO2014181137).Expert Opin Ther Pat. 2017 Mar;27(3):229-236. DM7GH4Y RU https://www.ncbi.nlm.nih.gov/pubmed/28092474 DM7GH4Y DI DM7GH4Y DM7GH4Y DN PMID28092474-Compound-33a DM7GH4Y MI TT5ZKDI DM7GH4Y MN Histone deacetylase 6 (HDAC6) DM7GH4Y MT DTT DM7GH4Y MA Inhibitor DM7GH4Y RN Novel histone deacetylase 6 (HDAC6) selective inhibitors: a patent evaluation (WO2014181137).Expert Opin Ther Pat. 2017 Mar;27(3):229-236. DM7GH4Y RU https://www.ncbi.nlm.nih.gov/pubmed/28092474 DMIJQZV DI DMIJQZV DMIJQZV DN PMID28092474-Compound-33b DMIJQZV MI TT6R7JZ DMIJQZV MN Histone deacetylase 1 (HDAC1) DMIJQZV MT DTT DMIJQZV MA Inhibitor DMIJQZV RN Novel histone deacetylase 6 (HDAC6) selective inhibitors: a patent evaluation (WO2014181137).Expert Opin Ther Pat. 2017 Mar;27(3):229-236. DMIJQZV RU https://www.ncbi.nlm.nih.gov/pubmed/28092474 DMIJQZV DI DMIJQZV DMIJQZV DN PMID28092474-Compound-33b DMIJQZV MI TT5ZKDI DMIJQZV MN Histone deacetylase 6 (HDAC6) DMIJQZV MT DTT DMIJQZV MA Inhibitor DMIJQZV RN Novel histone deacetylase 6 (HDAC6) selective inhibitors: a patent evaluation (WO2014181137).Expert Opin Ther Pat. 2017 Mar;27(3):229-236. DMIJQZV RU https://www.ncbi.nlm.nih.gov/pubmed/28092474 DM51JP6 DI DM51JP6 DM51JP6 DN PMID28092474-Compound-33c DM51JP6 MI TT6R7JZ DM51JP6 MN Histone deacetylase 1 (HDAC1) DM51JP6 MT DTT DM51JP6 MA Inhibitor DM51JP6 RN Novel histone deacetylase 6 (HDAC6) selective inhibitors: a patent evaluation (WO2014181137).Expert Opin Ther Pat. 2017 Mar;27(3):229-236. DM51JP6 RU https://www.ncbi.nlm.nih.gov/pubmed/28092474 DM51JP6 DI DM51JP6 DM51JP6 DN PMID28092474-Compound-33c DM51JP6 MI TT5ZKDI DM51JP6 MN Histone deacetylase 6 (HDAC6) DM51JP6 MT DTT DM51JP6 MA Inhibitor DM51JP6 RN Novel histone deacetylase 6 (HDAC6) selective inhibitors: a patent evaluation (WO2014181137).Expert Opin Ther Pat. 2017 Mar;27(3):229-236. DM51JP6 RU https://www.ncbi.nlm.nih.gov/pubmed/28092474 DMW38MK DI DMW38MK DMW38MK DN PMID28092474-Compound-33d DMW38MK MI TT6R7JZ DMW38MK MN Histone deacetylase 1 (HDAC1) DMW38MK MT DTT DMW38MK MA Inhibitor DMW38MK RN Novel histone deacetylase 6 (HDAC6) selective inhibitors: a patent evaluation (WO2014181137).Expert Opin Ther Pat. 2017 Mar;27(3):229-236. DMW38MK RU https://www.ncbi.nlm.nih.gov/pubmed/28092474 DMW38MK DI DMW38MK DMW38MK DN PMID28092474-Compound-33d DMW38MK MI TT5ZKDI DMW38MK MN Histone deacetylase 6 (HDAC6) DMW38MK MT DTT DMW38MK MA Inhibitor DMW38MK RN Novel histone deacetylase 6 (HDAC6) selective inhibitors: a patent evaluation (WO2014181137).Expert Opin Ther Pat. 2017 Mar;27(3):229-236. DMW38MK RU https://www.ncbi.nlm.nih.gov/pubmed/28092474 DMGTSXL DI DMGTSXL DMGTSXL DN PMID28092474-Compound-33e DMGTSXL MI TT6R7JZ DMGTSXL MN Histone deacetylase 1 (HDAC1) DMGTSXL MT DTT DMGTSXL MA Inhibitor DMGTSXL RN Novel histone deacetylase 6 (HDAC6) selective inhibitors: a patent evaluation (WO2014181137).Expert Opin Ther Pat. 2017 Mar;27(3):229-236. DMGTSXL RU https://www.ncbi.nlm.nih.gov/pubmed/28092474 DMGTSXL DI DMGTSXL DMGTSXL DN PMID28092474-Compound-33e DMGTSXL MI TT5ZKDI DMGTSXL MN Histone deacetylase 6 (HDAC6) DMGTSXL MT DTT DMGTSXL MA Inhibitor DMGTSXL RN Novel histone deacetylase 6 (HDAC6) selective inhibitors: a patent evaluation (WO2014181137).Expert Opin Ther Pat. 2017 Mar;27(3):229-236. DMGTSXL RU https://www.ncbi.nlm.nih.gov/pubmed/28092474 DMA360M DI DMA360M DMA360M DN PMID28092474-Compound-33f DMA360M MI TT6R7JZ DMA360M MN Histone deacetylase 1 (HDAC1) DMA360M MT DTT DMA360M MA Inhibitor DMA360M RN Novel histone deacetylase 6 (HDAC6) selective inhibitors: a patent evaluation (WO2014181137).Expert Opin Ther Pat. 2017 Mar;27(3):229-236. DMA360M RU https://www.ncbi.nlm.nih.gov/pubmed/28092474 DMA360M DI DMA360M DMA360M DN PMID28092474-Compound-33f DMA360M MI TT5ZKDI DMA360M MN Histone deacetylase 6 (HDAC6) DMA360M MT DTT DMA360M MA Inhibitor DMA360M RN Novel histone deacetylase 6 (HDAC6) selective inhibitors: a patent evaluation (WO2014181137).Expert Opin Ther Pat. 2017 Mar;27(3):229-236. DMA360M RU https://www.ncbi.nlm.nih.gov/pubmed/28092474 DM18DY6 DI DM18DY6 DM18DY6 DN PMID28092474-Compound-33g DM18DY6 MI TT6R7JZ DM18DY6 MN Histone deacetylase 1 (HDAC1) DM18DY6 MT DTT DM18DY6 MA Inhibitor DM18DY6 RN Novel histone deacetylase 6 (HDAC6) selective inhibitors: a patent evaluation (WO2014181137).Expert Opin Ther Pat. 2017 Mar;27(3):229-236. DM18DY6 RU https://www.ncbi.nlm.nih.gov/pubmed/28092474 DM18DY6 DI DM18DY6 DM18DY6 DN PMID28092474-Compound-33g DM18DY6 MI TT5ZKDI DM18DY6 MN Histone deacetylase 6 (HDAC6) DM18DY6 MT DTT DM18DY6 MA Inhibitor DM18DY6 RN Novel histone deacetylase 6 (HDAC6) selective inhibitors: a patent evaluation (WO2014181137).Expert Opin Ther Pat. 2017 Mar;27(3):229-236. DM18DY6 RU https://www.ncbi.nlm.nih.gov/pubmed/28092474 DM1DN6V DI DM1DN6V DM1DN6V DN PMID28092474-Compound-33h DM1DN6V MI TT6R7JZ DM1DN6V MN Histone deacetylase 1 (HDAC1) DM1DN6V MT DTT DM1DN6V MA Inhibitor DM1DN6V RN Novel histone deacetylase 6 (HDAC6) selective inhibitors: a patent evaluation (WO2014181137).Expert Opin Ther Pat. 2017 Mar;27(3):229-236. DM1DN6V RU https://www.ncbi.nlm.nih.gov/pubmed/28092474 DM1DN6V DI DM1DN6V DM1DN6V DN PMID28092474-Compound-33h DM1DN6V MI TT5ZKDI DM1DN6V MN Histone deacetylase 6 (HDAC6) DM1DN6V MT DTT DM1DN6V MA Inhibitor DM1DN6V RN Novel histone deacetylase 6 (HDAC6) selective inhibitors: a patent evaluation (WO2014181137).Expert Opin Ther Pat. 2017 Mar;27(3):229-236. DM1DN6V RU https://www.ncbi.nlm.nih.gov/pubmed/28092474 DM16E95 DI DM16E95 DM16E95 DN PMID28092474-Compound-33i DM16E95 MI TT6R7JZ DM16E95 MN Histone deacetylase 1 (HDAC1) DM16E95 MT DTT DM16E95 MA Inhibitor DM16E95 RN Novel histone deacetylase 6 (HDAC6) selective inhibitors: a patent evaluation (WO2014181137).Expert Opin Ther Pat. 2017 Mar;27(3):229-236. DM16E95 RU https://www.ncbi.nlm.nih.gov/pubmed/28092474 DM16E95 DI DM16E95 DM16E95 DN PMID28092474-Compound-33i DM16E95 MI TT5ZKDI DM16E95 MN Histone deacetylase 6 (HDAC6) DM16E95 MT DTT DM16E95 MA Inhibitor DM16E95 RN Novel histone deacetylase 6 (HDAC6) selective inhibitors: a patent evaluation (WO2014181137).Expert Opin Ther Pat. 2017 Mar;27(3):229-236. DM16E95 RU https://www.ncbi.nlm.nih.gov/pubmed/28092474 DMNTRIZ DI DMNTRIZ DMNTRIZ DN PMID28092474-Compound-33j DMNTRIZ MI TT6R7JZ DMNTRIZ MN Histone deacetylase 1 (HDAC1) DMNTRIZ MT DTT DMNTRIZ MA Inhibitor DMNTRIZ RN Novel histone deacetylase 6 (HDAC6) selective inhibitors: a patent evaluation (WO2014181137).Expert Opin Ther Pat. 2017 Mar;27(3):229-236. DMNTRIZ RU https://www.ncbi.nlm.nih.gov/pubmed/28092474 DMNTRIZ DI DMNTRIZ DMNTRIZ DN PMID28092474-Compound-33j DMNTRIZ MI TT5ZKDI DMNTRIZ MN Histone deacetylase 6 (HDAC6) DMNTRIZ MT DTT DMNTRIZ MA Inhibitor DMNTRIZ RN Novel histone deacetylase 6 (HDAC6) selective inhibitors: a patent evaluation (WO2014181137).Expert Opin Ther Pat. 2017 Mar;27(3):229-236. DMNTRIZ RU https://www.ncbi.nlm.nih.gov/pubmed/28092474 DMF2ZNT DI DMF2ZNT DMF2ZNT DN PMID28092474-Compound-33k DMF2ZNT MI TT6R7JZ DMF2ZNT MN Histone deacetylase 1 (HDAC1) DMF2ZNT MT DTT DMF2ZNT MA Inhibitor DMF2ZNT RN Novel histone deacetylase 6 (HDAC6) selective inhibitors: a patent evaluation (WO2014181137).Expert Opin Ther Pat. 2017 Mar;27(3):229-236. DMF2ZNT RU https://www.ncbi.nlm.nih.gov/pubmed/28092474 DMF2ZNT DI DMF2ZNT DMF2ZNT DN PMID28092474-Compound-33k DMF2ZNT MI TT5ZKDI DMF2ZNT MN Histone deacetylase 6 (HDAC6) DMF2ZNT MT DTT DMF2ZNT MA Inhibitor DMF2ZNT RN Novel histone deacetylase 6 (HDAC6) selective inhibitors: a patent evaluation (WO2014181137).Expert Opin Ther Pat. 2017 Mar;27(3):229-236. DMF2ZNT RU https://www.ncbi.nlm.nih.gov/pubmed/28092474 DMPJSB2 DI DMPJSB2 DMPJSB2 DN PMID28092474-Compound-33l DMPJSB2 MI TT6R7JZ DMPJSB2 MN Histone deacetylase 1 (HDAC1) DMPJSB2 MT DTT DMPJSB2 MA Inhibitor DMPJSB2 RN Novel histone deacetylase 6 (HDAC6) selective inhibitors: a patent evaluation (WO2014181137).Expert Opin Ther Pat. 2017 Mar;27(3):229-236. DMPJSB2 RU https://www.ncbi.nlm.nih.gov/pubmed/28092474 DMPJSB2 DI DMPJSB2 DMPJSB2 DN PMID28092474-Compound-33l DMPJSB2 MI TT5ZKDI DMPJSB2 MN Histone deacetylase 6 (HDAC6) DMPJSB2 MT DTT DMPJSB2 MA Inhibitor DMPJSB2 RN Novel histone deacetylase 6 (HDAC6) selective inhibitors: a patent evaluation (WO2014181137).Expert Opin Ther Pat. 2017 Mar;27(3):229-236. DMPJSB2 RU https://www.ncbi.nlm.nih.gov/pubmed/28092474 DMXSPT9 DI DMXSPT9 DMXSPT9 DN PMID28092474-Compound-33m DMXSPT9 MI TT6R7JZ DMXSPT9 MN Histone deacetylase 1 (HDAC1) DMXSPT9 MT DTT DMXSPT9 MA Inhibitor DMXSPT9 RN Novel histone deacetylase 6 (HDAC6) selective inhibitors: a patent evaluation (WO2014181137).Expert Opin Ther Pat. 2017 Mar;27(3):229-236. DMXSPT9 RU https://www.ncbi.nlm.nih.gov/pubmed/28092474 DMXSPT9 DI DMXSPT9 DMXSPT9 DN PMID28092474-Compound-33m DMXSPT9 MI TT5ZKDI DMXSPT9 MN Histone deacetylase 6 (HDAC6) DMXSPT9 MT DTT DMXSPT9 MA Inhibitor DMXSPT9 RN Novel histone deacetylase 6 (HDAC6) selective inhibitors: a patent evaluation (WO2014181137).Expert Opin Ther Pat. 2017 Mar;27(3):229-236. DMXSPT9 RU https://www.ncbi.nlm.nih.gov/pubmed/28092474 DM6DJZ7 DI DM6DJZ7 DM6DJZ7 DN PMID28092474-Compound-33o DM6DJZ7 MI TT6R7JZ DM6DJZ7 MN Histone deacetylase 1 (HDAC1) DM6DJZ7 MT DTT DM6DJZ7 MA Inhibitor DM6DJZ7 RN Novel histone deacetylase 6 (HDAC6) selective inhibitors: a patent evaluation (WO2014181137).Expert Opin Ther Pat. 2017 Mar;27(3):229-236. DM6DJZ7 RU https://www.ncbi.nlm.nih.gov/pubmed/28092474 DM6DJZ7 DI DM6DJZ7 DM6DJZ7 DN PMID28092474-Compound-33o DM6DJZ7 MI TT5ZKDI DM6DJZ7 MN Histone deacetylase 6 (HDAC6) DM6DJZ7 MT DTT DM6DJZ7 MA Inhibitor DM6DJZ7 RN Novel histone deacetylase 6 (HDAC6) selective inhibitors: a patent evaluation (WO2014181137).Expert Opin Ther Pat. 2017 Mar;27(3):229-236. DM6DJZ7 RU https://www.ncbi.nlm.nih.gov/pubmed/28092474 DMI8ZBK DI DMI8ZBK DMI8ZBK DN PMID28092474-Compound-33p DMI8ZBK MI TT6R7JZ DMI8ZBK MN Histone deacetylase 1 (HDAC1) DMI8ZBK MT DTT DMI8ZBK MA Inhibitor DMI8ZBK RN Novel histone deacetylase 6 (HDAC6) selective inhibitors: a patent evaluation (WO2014181137).Expert Opin Ther Pat. 2017 Mar;27(3):229-236. DMI8ZBK RU https://www.ncbi.nlm.nih.gov/pubmed/28092474 DMI8ZBK DI DMI8ZBK DMI8ZBK DN PMID28092474-Compound-33p DMI8ZBK MI TT5ZKDI DMI8ZBK MN Histone deacetylase 6 (HDAC6) DMI8ZBK MT DTT DMI8ZBK MA Inhibitor DMI8ZBK RN Novel histone deacetylase 6 (HDAC6) selective inhibitors: a patent evaluation (WO2014181137).Expert Opin Ther Pat. 2017 Mar;27(3):229-236. DMI8ZBK RU https://www.ncbi.nlm.nih.gov/pubmed/28092474 DM6JRCW DI DM6JRCW DM6JRCW DN PMID28092474-Compound-34 DM6JRCW MI TTBH0VX DM6JRCW MN Histone deacetylase (HDAC) DM6JRCW MT DTT DM6JRCW MA Inhibitor DM6JRCW RN Novel histone deacetylase 6 (HDAC6) selective inhibitors: a patent evaluation (WO2014181137).Expert Opin Ther Pat. 2017 Mar;27(3):229-236. DM6JRCW RU https://www.ncbi.nlm.nih.gov/pubmed/28092474 DMXQE7C DI DMXQE7C DMXQE7C DN PMID28092474-Compound-34a DMXQE7C MI TT6R7JZ DMXQE7C MN Histone deacetylase 1 (HDAC1) DMXQE7C MT DTT DMXQE7C MA Inhibitor DMXQE7C RN Novel histone deacetylase 6 (HDAC6) selective inhibitors: a patent evaluation (WO2014181137).Expert Opin Ther Pat. 2017 Mar;27(3):229-236. DMXQE7C RU https://www.ncbi.nlm.nih.gov/pubmed/28092474 DMXQE7C DI DMXQE7C DMXQE7C DN PMID28092474-Compound-34a DMXQE7C MI TT5ZKDI DMXQE7C MN Histone deacetylase 6 (HDAC6) DMXQE7C MT DTT DMXQE7C MA Inhibitor DMXQE7C RN Novel histone deacetylase 6 (HDAC6) selective inhibitors: a patent evaluation (WO2014181137).Expert Opin Ther Pat. 2017 Mar;27(3):229-236. DMXQE7C RU https://www.ncbi.nlm.nih.gov/pubmed/28092474 DM6X2CO DI DM6X2CO DM6X2CO DN PMID28092474-Compound-34b DM6X2CO MI TT6R7JZ DM6X2CO MN Histone deacetylase 1 (HDAC1) DM6X2CO MT DTT DM6X2CO MA Inhibitor DM6X2CO RN Novel histone deacetylase 6 (HDAC6) selective inhibitors: a patent evaluation (WO2014181137).Expert Opin Ther Pat. 2017 Mar;27(3):229-236. DM6X2CO RU https://www.ncbi.nlm.nih.gov/pubmed/28092474 DM6X2CO DI DM6X2CO DM6X2CO DN PMID28092474-Compound-34b DM6X2CO MI TT5ZKDI DM6X2CO MN Histone deacetylase 6 (HDAC6) DM6X2CO MT DTT DM6X2CO MA Inhibitor DM6X2CO RN Novel histone deacetylase 6 (HDAC6) selective inhibitors: a patent evaluation (WO2014181137).Expert Opin Ther Pat. 2017 Mar;27(3):229-236. DM6X2CO RU https://www.ncbi.nlm.nih.gov/pubmed/28092474 DMMI7DY DI DMMI7DY DMMI7DY DN PMID28092474-Compound-34c DMMI7DY MI TT6R7JZ DMMI7DY MN Histone deacetylase 1 (HDAC1) DMMI7DY MT DTT DMMI7DY MA Inhibitor DMMI7DY RN Novel histone deacetylase 6 (HDAC6) selective inhibitors: a patent evaluation (WO2014181137).Expert Opin Ther Pat. 2017 Mar;27(3):229-236. DMMI7DY RU https://www.ncbi.nlm.nih.gov/pubmed/28092474 DMMI7DY DI DMMI7DY DMMI7DY DN PMID28092474-Compound-34c DMMI7DY MI TT5ZKDI DMMI7DY MN Histone deacetylase 6 (HDAC6) DMMI7DY MT DTT DMMI7DY MA Inhibitor DMMI7DY RN Novel histone deacetylase 6 (HDAC6) selective inhibitors: a patent evaluation (WO2014181137).Expert Opin Ther Pat. 2017 Mar;27(3):229-236. DMMI7DY RU https://www.ncbi.nlm.nih.gov/pubmed/28092474 DMAXS57 DI DMAXS57 DMAXS57 DN PMID28117607-Compound-20 DMAXS57 MI TTK0FEA DMAXS57 MN Leucine-rich repeat kinase 2 (LRRK2) DMAXS57 MT DTT DMAXS57 MA Inhibitor DMAXS57 RN Leucine-rich repeat kinase 2 inhibitors: a patent review (2014-2016).Expert Opin Ther Pat. 2017 Jun;27(6):667-676. DMAXS57 RU https://www.ncbi.nlm.nih.gov/pubmed/28117607 DMS8OTG DI DMS8OTG DMS8OTG DN PMID28117607-Compound-21 DMS8OTG MI TTK0FEA DMS8OTG MN Leucine-rich repeat kinase 2 (LRRK2) DMS8OTG MT DTT DMS8OTG MA Inhibitor DMS8OTG RN Leucine-rich repeat kinase 2 inhibitors: a patent review (2014-2016).Expert Opin Ther Pat. 2017 Jun;27(6):667-676. DMS8OTG RU https://www.ncbi.nlm.nih.gov/pubmed/28117607 DMVIY73 DI DMVIY73 DMVIY73 DN PMID28117607-Compound-4 DMVIY73 MI TTK0FEA DMVIY73 MN Leucine-rich repeat kinase 2 (LRRK2) DMVIY73 MT DTT DMVIY73 MA Inhibitor DMVIY73 RN Leucine-rich repeat kinase 2 inhibitors: a patent review (2014-2016).Expert Opin Ther Pat. 2017 Jun;27(6):667-676. DMVIY73 RU https://www.ncbi.nlm.nih.gov/pubmed/28117607 DMPBNFM DI DMPBNFM DMPBNFM DN PMID28117607-Compound-5 DMPBNFM MI TTK0FEA DMPBNFM MN Leucine-rich repeat kinase 2 (LRRK2) DMPBNFM MT DTT DMPBNFM MA Inhibitor DMPBNFM RN Leucine-rich repeat kinase 2 inhibitors: a patent review (2014-2016).Expert Opin Ther Pat. 2017 Jun;27(6):667-676. DMPBNFM RU https://www.ncbi.nlm.nih.gov/pubmed/28117607 DM68B1R DI DM68B1R DM68B1R DN PMID28117607-Compound-6 DM68B1R MI TTK0FEA DM68B1R MN Leucine-rich repeat kinase 2 (LRRK2) DM68B1R MT DTT DM68B1R MA Inhibitor DM68B1R RN Leucine-rich repeat kinase 2 inhibitors: a patent review (2014-2016).Expert Opin Ther Pat. 2017 Jun;27(6):667-676. DM68B1R RU https://www.ncbi.nlm.nih.gov/pubmed/28117607 DMJZREU DI DMJZREU DMJZREU DN PMID28117607-Compound-7 DMJZREU MI TTK0FEA DMJZREU MN Leucine-rich repeat kinase 2 (LRRK2) DMJZREU MT DTT DMJZREU MA Inhibitor DMJZREU RN Leucine-rich repeat kinase 2 inhibitors: a patent review (2014-2016).Expert Opin Ther Pat. 2017 Jun;27(6):667-676. DMJZREU RU https://www.ncbi.nlm.nih.gov/pubmed/28117607 DMBHRUP DI DMBHRUP DMBHRUP DN PMID28270010-Compound-Figure16-a DMBHRUP MI TTTDVOJ DMBHRUP MN Tropomyosin-related kinase A (TrkA) DMBHRUP MT DTT DMBHRUP MA Inhibitor DMBHRUP RN Tropomyosin receptor kinase inhibitors: an updated patent review for 2010-2016 - Part I.Expert Opin Ther Pat. 2017 Jun;27(6):733-751. DMBHRUP RU https://www.ncbi.nlm.nih.gov/pubmed/28270010 DMAIRL2 DI DMAIRL2 DMAIRL2 DN PMID28270010-Compound-Figure16-b-1 DMAIRL2 MI TTTDVOJ DMAIRL2 MN Tropomyosin-related kinase A (TrkA) DMAIRL2 MT DTT DMAIRL2 MA Inhibitor DMAIRL2 RN Tropomyosin receptor kinase inhibitors: an updated patent review for 2010-2016 - Part I.Expert Opin Ther Pat. 2017 Jun;27(6):733-751. DMAIRL2 RU https://www.ncbi.nlm.nih.gov/pubmed/28270010 DM6YLMB DI DM6YLMB DM6YLMB DN PMID28270010-Compound-Figure16-b-2 DM6YLMB MI TTTDVOJ DM6YLMB MN Tropomyosin-related kinase A (TrkA) DM6YLMB MT DTT DM6YLMB MA Inhibitor DM6YLMB RN Tropomyosin receptor kinase inhibitors: an updated patent review for 2010-2016 - Part I.Expert Opin Ther Pat. 2017 Jun;27(6):733-751. DM6YLMB RU https://www.ncbi.nlm.nih.gov/pubmed/28270010 DMPOI27 DI DMPOI27 DMPOI27 DN PMID28270010-Compound-Figure17-1 DMPOI27 MI TTTDVOJ DMPOI27 MN Tropomyosin-related kinase A (TrkA) DMPOI27 MT DTT DMPOI27 MA Inhibitor DMPOI27 RN Tropomyosin receptor kinase inhibitors: an updated patent review for 2010-2016 - Part I.Expert Opin Ther Pat. 2017 Jun;27(6):733-751. DMPOI27 RU https://www.ncbi.nlm.nih.gov/pubmed/28270010 DM7QLX8 DI DM7QLX8 DM7QLX8 DN PMID28270010-Compound-Figure17-2 DM7QLX8 MI TTTDVOJ DM7QLX8 MN Tropomyosin-related kinase A (TrkA) DM7QLX8 MT DTT DM7QLX8 MA Inhibitor DM7QLX8 RN Tropomyosin receptor kinase inhibitors: an updated patent review for 2010-2016 - Part I.Expert Opin Ther Pat. 2017 Jun;27(6):733-751. DM7QLX8 RU https://www.ncbi.nlm.nih.gov/pubmed/28270010 DME0TUJ DI DME0TUJ DME0TUJ DN PMID28270010-Compound-Figure17-3 DME0TUJ MI TTTDVOJ DME0TUJ MN Tropomyosin-related kinase A (TrkA) DME0TUJ MT DTT DME0TUJ MA Inhibitor DME0TUJ RN Tropomyosin receptor kinase inhibitors: an updated patent review for 2010-2016 - Part I.Expert Opin Ther Pat. 2017 Jun;27(6):733-751. DME0TUJ RU https://www.ncbi.nlm.nih.gov/pubmed/28270010 DM6IYAT DI DM6IYAT DM6IYAT DN PMID28270010-Compound-Figure21-b DM6IYAT MI TTPMQSO DM6IYAT MN ALK tyrosine kinase receptor (ALK) DM6IYAT MT DTT DM6IYAT MA Inhibitor DM6IYAT RN Tropomyosin receptor kinase inhibitors: an updated patent review for 2010-2016 - Part I.Expert Opin Ther Pat. 2017 Jun;27(6):733-751. DM6IYAT RU https://www.ncbi.nlm.nih.gov/pubmed/28270010 DM6IYAT DI DM6IYAT DM6IYAT DN PMID28270010-Compound-Figure21-b DM6IYAT MI TTSZ6Y3 DM6IYAT MN Proto-oncogene c-Ros (ROS1) DM6IYAT MT DTT DM6IYAT MA Inhibitor DM6IYAT RN Tropomyosin receptor kinase inhibitors: an updated patent review for 2010-2016 - Part I.Expert Opin Ther Pat. 2017 Jun;27(6):733-751. DM6IYAT RU https://www.ncbi.nlm.nih.gov/pubmed/28270010 DMNTQL5 DI DMNTQL5 DMNTQL5 DN PMID28270010-Compound-Figure24-a DMNTQL5 MI TT7MRDV DMNTQL5 MN Macrophage colony-stimulating factor 1 receptor (CSF1R) DMNTQL5 MT DTT DMNTQL5 MA Inhibitor DMNTQL5 RN Tropomyosin receptor kinase inhibitors: an updated patent review for 2010-2016 - Part I.Expert Opin Ther Pat. 2017 Jun;27(6):733-751. DMNTQL5 RU https://www.ncbi.nlm.nih.gov/pubmed/28270010 DMNTQL5 DI DMNTQL5 DMNTQL5 DN PMID28270010-Compound-Figure24-a DMNTQL5 MI TTTDVOJ DMNTQL5 MN Tropomyosin-related kinase A (TrkA) DMNTQL5 MT DTT DMNTQL5 MA Inhibitor DMNTQL5 RN Tropomyosin receptor kinase inhibitors: an updated patent review for 2010-2016 - Part I.Expert Opin Ther Pat. 2017 Jun;27(6):733-751. DMNTQL5 RU https://www.ncbi.nlm.nih.gov/pubmed/28270010 DM0QHLK DI DM0QHLK DM0QHLK DN PMID28270010-Compound-Figure24-b DM0QHLK MI TTKN7QR DM0QHLK MN BDNF/NT-3 growth factors receptor (TrkB) DM0QHLK MT DTT DM0QHLK MA Inhibitor DM0QHLK RN Tropomyosin receptor kinase inhibitors: an updated patent review for 2010-2016 - Part I.Expert Opin Ther Pat. 2017 Jun;27(6):733-751. DM0QHLK RU https://www.ncbi.nlm.nih.gov/pubmed/28270010 DM0QHLK DI DM0QHLK DM0QHLK DN PMID28270010-Compound-Figure24-b DM0QHLK MI TTXABCW DM0QHLK MN NT-3 growth factor receptor (TrkC) DM0QHLK MT DTT DM0QHLK MA Inhibitor DM0QHLK RN Tropomyosin receptor kinase inhibitors: an updated patent review for 2010-2016 - Part I.Expert Opin Ther Pat. 2017 Jun;27(6):733-751. DM0QHLK RU https://www.ncbi.nlm.nih.gov/pubmed/28270010 DM0QHLK DI DM0QHLK DM0QHLK DN PMID28270010-Compound-Figure24-b DM0QHLK MI TTTDVOJ DM0QHLK MN Tropomyosin-related kinase A (TrkA) DM0QHLK MT DTT DM0QHLK MA Inhibitor DM0QHLK RN Tropomyosin receptor kinase inhibitors: an updated patent review for 2010-2016 - Part I.Expert Opin Ther Pat. 2017 Jun;27(6):733-751. DM0QHLK RU https://www.ncbi.nlm.nih.gov/pubmed/28270010 DM2YAPJ DI DM2YAPJ DM2YAPJ DN PMID28270010-Compound-Figure5-1 DM2YAPJ MI TTKN7QR DM2YAPJ MN BDNF/NT-3 growth factors receptor (TrkB) DM2YAPJ MT DTT DM2YAPJ MA Inhibitor DM2YAPJ RN Tropomyosin receptor kinase inhibitors: an updated patent review for 2010-2016 - Part I.Expert Opin Ther Pat. 2017 Jun;27(6):733-751. DM2YAPJ RU https://www.ncbi.nlm.nih.gov/pubmed/28270010 DM2YAPJ DI DM2YAPJ DM2YAPJ DN PMID28270010-Compound-Figure5-1 DM2YAPJ MI TTXABCW DM2YAPJ MN NT-3 growth factor receptor (TrkC) DM2YAPJ MT DTT DM2YAPJ MA Inhibitor DM2YAPJ RN Tropomyosin receptor kinase inhibitors: an updated patent review for 2010-2016 - Part I.Expert Opin Ther Pat. 2017 Jun;27(6):733-751. DM2YAPJ RU https://www.ncbi.nlm.nih.gov/pubmed/28270010 DM2YAPJ DI DM2YAPJ DM2YAPJ DN PMID28270010-Compound-Figure5-1 DM2YAPJ MI TTTDVOJ DM2YAPJ MN Tropomyosin-related kinase A (TrkA) DM2YAPJ MT DTT DM2YAPJ MA Inhibitor DM2YAPJ RN Tropomyosin receptor kinase inhibitors: an updated patent review for 2010-2016 - Part I.Expert Opin Ther Pat. 2017 Jun;27(6):733-751. DM2YAPJ RU https://www.ncbi.nlm.nih.gov/pubmed/28270010 DMK3GRZ DI DMK3GRZ DMK3GRZ DN PMID28270010-Compound-Figure5-2 DMK3GRZ MI TTKN7QR DMK3GRZ MN BDNF/NT-3 growth factors receptor (TrkB) DMK3GRZ MT DTT DMK3GRZ MA Inhibitor DMK3GRZ RN Tropomyosin receptor kinase inhibitors: an updated patent review for 2010-2016 - Part I.Expert Opin Ther Pat. 2017 Jun;27(6):733-751. DMK3GRZ RU https://www.ncbi.nlm.nih.gov/pubmed/28270010 DMK3GRZ DI DMK3GRZ DMK3GRZ DN PMID28270010-Compound-Figure5-2 DMK3GRZ MI TTXABCW DMK3GRZ MN NT-3 growth factor receptor (TrkC) DMK3GRZ MT DTT DMK3GRZ MA Inhibitor DMK3GRZ RN Tropomyosin receptor kinase inhibitors: an updated patent review for 2010-2016 - Part I.Expert Opin Ther Pat. 2017 Jun;27(6):733-751. DMK3GRZ RU https://www.ncbi.nlm.nih.gov/pubmed/28270010 DMK3GRZ DI DMK3GRZ DMK3GRZ DN PMID28270010-Compound-Figure5-2 DMK3GRZ MI TTTDVOJ DMK3GRZ MN Tropomyosin-related kinase A (TrkA) DMK3GRZ MT DTT DMK3GRZ MA Inhibitor DMK3GRZ RN Tropomyosin receptor kinase inhibitors: an updated patent review for 2010-2016 - Part I.Expert Opin Ther Pat. 2017 Jun;27(6):733-751. DMK3GRZ RU https://www.ncbi.nlm.nih.gov/pubmed/28270010 DMSOT1R DI DMSOT1R DMSOT1R DN PMID28270010-Compound-Figure5-3 DMSOT1R MI TTKN7QR DMSOT1R MN BDNF/NT-3 growth factors receptor (TrkB) DMSOT1R MT DTT DMSOT1R MA Inhibitor DMSOT1R RN Tropomyosin receptor kinase inhibitors: an updated patent review for 2010-2016 - Part I.Expert Opin Ther Pat. 2017 Jun;27(6):733-751. DMSOT1R RU https://www.ncbi.nlm.nih.gov/pubmed/28270010 DMSOT1R DI DMSOT1R DMSOT1R DN PMID28270010-Compound-Figure5-3 DMSOT1R MI TTXABCW DMSOT1R MN NT-3 growth factor receptor (TrkC) DMSOT1R MT DTT DMSOT1R MA Inhibitor DMSOT1R RN Tropomyosin receptor kinase inhibitors: an updated patent review for 2010-2016 - Part I.Expert Opin Ther Pat. 2017 Jun;27(6):733-751. DMSOT1R RU https://www.ncbi.nlm.nih.gov/pubmed/28270010 DMSOT1R DI DMSOT1R DMSOT1R DN PMID28270010-Compound-Figure5-3 DMSOT1R MI TTTDVOJ DMSOT1R MN Tropomyosin-related kinase A (TrkA) DMSOT1R MT DTT DMSOT1R MA Inhibitor DMSOT1R RN Tropomyosin receptor kinase inhibitors: an updated patent review for 2010-2016 - Part I.Expert Opin Ther Pat. 2017 Jun;27(6):733-751. DMSOT1R RU https://www.ncbi.nlm.nih.gov/pubmed/28270010 DM437ZC DI DM437ZC DM437ZC DN PMID28270021-Compound-WO2010077680 103 DM437ZC MI TTTDVOJ DM437ZC MN Tropomyosin-related kinase A (TrkA) DM437ZC MT DTT DM437ZC MA Antagonist DM437ZC RN Tropomyosin receptor kinase inhibitors: an updated patent review for 2010-2016 - Part II.Expert Opin Ther Pat. 2017 Jul;27(7):831-849. DM437ZC RU https://www.ncbi.nlm.nih.gov/pubmed/28270021 DMNUA21 DI DMNUA21 DMNUA21 DN PMID28270021-Compound-WO2010077680 109 DMNUA21 MI TTTDVOJ DMNUA21 MN Tropomyosin-related kinase A (TrkA) DMNUA21 MT DTT DMNUA21 MA Antagonist DMNUA21 RN Tropomyosin receptor kinase inhibitors: an updated patent review for 2010-2016 - Part II.Expert Opin Ther Pat. 2017 Jul;27(7):831-849. DMNUA21 RU https://www.ncbi.nlm.nih.gov/pubmed/28270021 DMQAZMC DI DMQAZMC DMQAZMC DN PMID28270021-Compound-WO2010077680 201 DMQAZMC MI TTTDVOJ DMQAZMC MN Tropomyosin-related kinase A (TrkA) DMQAZMC MT DTT DMQAZMC MA Antagonist DMQAZMC RN Tropomyosin receptor kinase inhibitors: an updated patent review for 2010-2016 - Part II.Expert Opin Ther Pat. 2017 Jul;27(7):831-849. DMQAZMC RU https://www.ncbi.nlm.nih.gov/pubmed/28270021 DM6VAS2 DI DM6VAS2 DM6VAS2 DN PMID28270021-Compound-WO2010077680 481 DM6VAS2 MI TTTDVOJ DM6VAS2 MN Tropomyosin-related kinase A (TrkA) DM6VAS2 MT DTT DM6VAS2 MA Antagonist DM6VAS2 RN Tropomyosin receptor kinase inhibitors: an updated patent review for 2010-2016 - Part II.Expert Opin Ther Pat. 2017 Jul;27(7):831-849. DM6VAS2 RU https://www.ncbi.nlm.nih.gov/pubmed/28270021 DMQ9CBS DI DMQ9CBS DMQ9CBS DN PMID28270021-Compound-WO2010077680 495 DMQ9CBS MI TTTDVOJ DMQ9CBS MN Tropomyosin-related kinase A (TrkA) DMQ9CBS MT DTT DMQ9CBS MA Antagonist DMQ9CBS RN Tropomyosin receptor kinase inhibitors: an updated patent review for 2010-2016 - Part II.Expert Opin Ther Pat. 2017 Jul;27(7):831-849. DMQ9CBS RU https://www.ncbi.nlm.nih.gov/pubmed/28270021 DM6TJU0 DI DM6TJU0 DM6TJU0 DN PMID28270021-Compound-WO2010077680 803 DM6TJU0 MI TTTDVOJ DM6TJU0 MN Tropomyosin-related kinase A (TrkA) DM6TJU0 MT DTT DM6TJU0 MA Antagonist DM6TJU0 RN Tropomyosin receptor kinase inhibitors: an updated patent review for 2010-2016 - Part II.Expert Opin Ther Pat. 2017 Jul;27(7):831-849. DM6TJU0 RU https://www.ncbi.nlm.nih.gov/pubmed/28270021 DM47FNS DI DM47FNS DM47FNS DN PMID28270021-Compound-WO2010077680 811 DM47FNS MI TTTDVOJ DM47FNS MN Tropomyosin-related kinase A (TrkA) DM47FNS MT DTT DM47FNS MA Antagonist DM47FNS RN Tropomyosin receptor kinase inhibitors: an updated patent review for 2010-2016 - Part II.Expert Opin Ther Pat. 2017 Jul;27(7):831-849. DM47FNS RU https://www.ncbi.nlm.nih.gov/pubmed/28270021 DMVS7CJ DI DMVS7CJ DMVS7CJ DN PMID28270021-Compound-WO2013009582Example16 DMVS7CJ MI TTTDVOJ DMVS7CJ MN Tropomyosin-related kinase A (TrkA) DMVS7CJ MT DTT DMVS7CJ MA Inhibitor DMVS7CJ RN Tropomyosin receptor kinase inhibitors: an updated patent review for 2010-2016 - Part II.Expert Opin Ther Pat. 2017 Jul;27(7):831-849. DMVS7CJ RU https://www.ncbi.nlm.nih.gov/pubmed/28270021 DMQK4IX DI DMQK4IX DMQK4IX DN PMID28270021-Compound-WO2013009582Example76 DMQK4IX MI TTTDVOJ DMQK4IX MN Tropomyosin-related kinase A (TrkA) DMQK4IX MT DTT DMQK4IX MA Inhibitor DMQK4IX RN Tropomyosin receptor kinase inhibitors: an updated patent review for 2010-2016 - Part II.Expert Opin Ther Pat. 2017 Jul;27(7):831-849. DMQK4IX RU https://www.ncbi.nlm.nih.gov/pubmed/28270021 DM2XKTB DI DM2XKTB DM2XKTB DN PMID28270021-Compound-WO2013161919Example85-117 DM2XKTB MI TTTDVOJ DM2XKTB MN Tropomyosin-related kinase A (TrkA) DM2XKTB MT DTT DM2XKTB MA Inhibitor DM2XKTB RN Tropomyosin receptor kinase inhibitors: an updated patent review for 2010-2016 - Part II.Expert Opin Ther Pat. 2017 Jul;27(7):831-849. DM2XKTB RU https://www.ncbi.nlm.nih.gov/pubmed/28270021 DMO02EL DI DMO02EL DMO02EL DN PMID28270021-Compound-WO2014078408Example1 DMO02EL MI TTTDVOJ DMO02EL MN Tropomyosin-related kinase A (TrkA) DMO02EL MT DTT DMO02EL MA Inhibitor DMO02EL RN Tropomyosin receptor kinase inhibitors: an updated patent review for 2010-2016 - Part II.Expert Opin Ther Pat. 2017 Jul;27(7):831-849. DMO02EL RU https://www.ncbi.nlm.nih.gov/pubmed/28270021 DMVCBSK DI DMVCBSK DMVCBSK DN PMID28270021-Compound-WO2014078408Example26 DMVCBSK MI TTTDVOJ DMVCBSK MN Tropomyosin-related kinase A (TrkA) DMVCBSK MT DTT DMVCBSK MA Inhibitor DMVCBSK RN Tropomyosin receptor kinase inhibitors: an updated patent review for 2010-2016 - Part II.Expert Opin Ther Pat. 2017 Jul;27(7):831-849. DMVCBSK RU https://www.ncbi.nlm.nih.gov/pubmed/28270021 DMKO4ZH DI DMKO4ZH DMKO4ZH DN PMID28270021-Compound-WO2014129431Example8-1 DMKO4ZH MI TTTDVOJ DMKO4ZH MN Tropomyosin-related kinase A (TrkA) DMKO4ZH MT DTT DMKO4ZH MA Inhibitor DMKO4ZH RN Tropomyosin receptor kinase inhibitors: an updated patent review for 2010-2016 - Part II.Expert Opin Ther Pat. 2017 Jul;27(7):831-849. DMKO4ZH RU https://www.ncbi.nlm.nih.gov/pubmed/28270021 DMA04P6 DI DMA04P6 DMA04P6 DN PMID28270021-Compound-WO2014152663 701 DMA04P6 MI TTTDVOJ DMA04P6 MN Tropomyosin-related kinase A (TrkA) DMA04P6 MT DTT DMA04P6 MA Inhibitor DMA04P6 RN Tropomyosin receptor kinase inhibitors: an updated patent review for 2010-2016 - Part II.Expert Opin Ther Pat. 2017 Jul;27(7):831-849. DMA04P6 RU https://www.ncbi.nlm.nih.gov/pubmed/28270021 DM16URY DI DM16URY DM16URY DN PMID28270021-Compound-WO2015042088Example11 DM16URY MI TTTDVOJ DM16URY MN Tropomyosin-related kinase A (TrkA) DM16URY MT DTT DM16URY MA Inhibitor DM16URY RN Tropomyosin receptor kinase inhibitors: an updated patent review for 2010-2016 - Part II.Expert Opin Ther Pat. 2017 Jul;27(7):831-849. DM16URY RU https://www.ncbi.nlm.nih.gov/pubmed/28270021 DMOZHGU DI DMOZHGU DMOZHGU DN PMID28270021-Compound-WO2015042088Example12 DMOZHGU MI TTTDVOJ DMOZHGU MN Tropomyosin-related kinase A (TrkA) DMOZHGU MT DTT DMOZHGU MA Inhibitor DMOZHGU RN Tropomyosin receptor kinase inhibitors: an updated patent review for 2010-2016 - Part II.Expert Opin Ther Pat. 2017 Jul;27(7):831-849. DMOZHGU RU https://www.ncbi.nlm.nih.gov/pubmed/28270021 DM6KXOQ DI DM6KXOQ DM6KXOQ DN PMID28270021-Compound-WO2015042088Example4 DM6KXOQ MI TTKN7QR DM6KXOQ MN BDNF/NT-3 growth factors receptor (TrkB) DM6KXOQ MT DTT DM6KXOQ MA Inhibitor DM6KXOQ RN Tropomyosin receptor kinase inhibitors: an updated patent review for 2010-2016 - Part II.Expert Opin Ther Pat. 2017 Jul;27(7):831-849. DM6KXOQ RU https://www.ncbi.nlm.nih.gov/pubmed/28270021 DM6KXOQ DI DM6KXOQ DM6KXOQ DN PMID28270021-Compound-WO2015042088Example4 DM6KXOQ MI TTXABCW DM6KXOQ MN NT-3 growth factor receptor (TrkC) DM6KXOQ MT DTT DM6KXOQ MA Inhibitor DM6KXOQ RN Tropomyosin receptor kinase inhibitors: an updated patent review for 2010-2016 - Part II.Expert Opin Ther Pat. 2017 Jul;27(7):831-849. DM6KXOQ RU https://www.ncbi.nlm.nih.gov/pubmed/28270021 DM6KXOQ DI DM6KXOQ DM6KXOQ DN PMID28270021-Compound-WO2015042088Example4 DM6KXOQ MI TTTDVOJ DM6KXOQ MN Tropomyosin-related kinase A (TrkA) DM6KXOQ MT DTT DM6KXOQ MA Inhibitor DM6KXOQ RN Tropomyosin receptor kinase inhibitors: an updated patent review for 2010-2016 - Part II.Expert Opin Ther Pat. 2017 Jul;27(7):831-849. DM6KXOQ RU https://www.ncbi.nlm.nih.gov/pubmed/28270021 DMD5QEL DI DMD5QEL DMD5QEL DN PMID28270021-Compound-WO2016054807Example1 DMD5QEL MI TTKN7QR DMD5QEL MN BDNF/NT-3 growth factors receptor (TrkB) DMD5QEL MT DTT DMD5QEL MA Inhibitor DMD5QEL RN Tropomyosin receptor kinase inhibitors: an updated patent review for 2010-2016 - Part II.Expert Opin Ther Pat. 2017 Jul;27(7):831-849. DMD5QEL RU https://www.ncbi.nlm.nih.gov/pubmed/28270021 DMD5QEL DI DMD5QEL DMD5QEL DN PMID28270021-Compound-WO2016054807Example1 DMD5QEL MI TTXABCW DMD5QEL MN NT-3 growth factor receptor (TrkC) DMD5QEL MT DTT DMD5QEL MA Inhibitor DMD5QEL RN Tropomyosin receptor kinase inhibitors: an updated patent review for 2010-2016 - Part II.Expert Opin Ther Pat. 2017 Jul;27(7):831-849. DMD5QEL RU https://www.ncbi.nlm.nih.gov/pubmed/28270021 DMD5QEL DI DMD5QEL DMD5QEL DN PMID28270021-Compound-WO2016054807Example1 DMD5QEL MI TTTDVOJ DMD5QEL MN Tropomyosin-related kinase A (TrkA) DMD5QEL MT DTT DMD5QEL MA Inhibitor DMD5QEL RN Tropomyosin receptor kinase inhibitors: an updated patent review for 2010-2016 - Part II.Expert Opin Ther Pat. 2017 Jul;27(7):831-849. DMD5QEL RU https://www.ncbi.nlm.nih.gov/pubmed/28270021 DMW2ZRM DI DMW2ZRM DMW2ZRM DN PMID28270021-Compound-WO2016054807Example112 DMW2ZRM MI TTTDVOJ DMW2ZRM MN Tropomyosin-related kinase A (TrkA) DMW2ZRM MT DTT DMW2ZRM MA Inhibitor DMW2ZRM RN Tropomyosin receptor kinase inhibitors: an updated patent review for 2010-2016 - Part II.Expert Opin Ther Pat. 2017 Jul;27(7):831-849. DMW2ZRM RU https://www.ncbi.nlm.nih.gov/pubmed/28270021 DMREZ9I DI DMREZ9I DMREZ9I DN PMID28270021-Compound-WO2016054807Example71 DMREZ9I MI TTTDVOJ DMREZ9I MN Tropomyosin-related kinase A (TrkA) DMREZ9I MT DTT DMREZ9I MA Inhibitor DMREZ9I RN Tropomyosin receptor kinase inhibitors: an updated patent review for 2010-2016 - Part II.Expert Opin Ther Pat. 2017 Jul;27(7):831-849. DMREZ9I RU https://www.ncbi.nlm.nih.gov/pubmed/28270021 DMPI86D DI DMPI86D DMPI86D DN PMID28270021-Compound-WO2016054807Example80 DMPI86D MI TTTDVOJ DMPI86D MN Tropomyosin-related kinase A (TrkA) DMPI86D MT DTT DMPI86D MA Inhibitor DMPI86D RN Tropomyosin receptor kinase inhibitors: an updated patent review for 2010-2016 - Part II.Expert Opin Ther Pat. 2017 Jul;27(7):831-849. DMPI86D RU https://www.ncbi.nlm.nih.gov/pubmed/28270021 DM9ADSN DI DM9ADSN DM9ADSN DN PMID28270021-Compound-WO2016054807Example82 DM9ADSN MI TTTDVOJ DM9ADSN MN Tropomyosin-related kinase A (TrkA) DM9ADSN MT DTT DM9ADSN MA Inhibitor DM9ADSN RN Tropomyosin receptor kinase inhibitors: an updated patent review for 2010-2016 - Part II.Expert Opin Ther Pat. 2017 Jul;27(7):831-849. DM9ADSN RU https://www.ncbi.nlm.nih.gov/pubmed/28270021 DMSEIL0 DI DMSEIL0 DMSEIL0 DN PMID28350212-Compound-1 DMSEIL0 MI TTZS04O DMSEIL0 MN Gamma-secretase subunit APH-1A/1B (APH-1) DMSEIL0 MT DTT DMSEIL0 MA Inhibitor DMSEIL0 RN Gamma secretase inhibitors: a patent review (2013 - 2015).Expert Opin Ther Pat. 2017 Jul;27(7):851-866. DMSEIL0 RU https://www.ncbi.nlm.nih.gov/pubmed/28350212 DME72ZH DI DME72ZH DME72ZH DN PMID28350212-Compound-12 DME72ZH MI TTZS04O DME72ZH MN Gamma-secretase subunit APH-1A/1B (APH-1) DME72ZH MT DTT DME72ZH MA Inhibitor DME72ZH RN Gamma secretase inhibitors: a patent review (2013 - 2015).Expert Opin Ther Pat. 2017 Jul;27(7):851-866. DME72ZH RU https://www.ncbi.nlm.nih.gov/pubmed/28350212 DMPWYL8 DI DMPWYL8 DMPWYL8 DN PMID28350212-Compound-13 DMPWYL8 MI TTZS04O DMPWYL8 MN Gamma-secretase subunit APH-1A/1B (APH-1) DMPWYL8 MT DTT DMPWYL8 MA Inhibitor DMPWYL8 RN Gamma secretase inhibitors: a patent review (2013 - 2015).Expert Opin Ther Pat. 2017 Jul;27(7):851-866. DMPWYL8 RU https://www.ncbi.nlm.nih.gov/pubmed/28350212 DMSFL5B DI DMSFL5B DMSFL5B DN PMID28350212-Compound-15 DMSFL5B MI TTZS04O DMSFL5B MN Gamma-secretase subunit APH-1A/1B (APH-1) DMSFL5B MT DTT DMSFL5B MA Inhibitor DMSFL5B RN Gamma secretase inhibitors: a patent review (2013 - 2015).Expert Opin Ther Pat. 2017 Jul;27(7):851-866. DMSFL5B RU https://www.ncbi.nlm.nih.gov/pubmed/28350212 DMA1RP9 DI DMA1RP9 DMA1RP9 DN PMID28350212-Compound-16 DMA1RP9 MI TTZS04O DMA1RP9 MN Gamma-secretase subunit APH-1A/1B (APH-1) DMA1RP9 MT DTT DMA1RP9 MA Inhibitor DMA1RP9 RN Gamma secretase inhibitors: a patent review (2013 - 2015).Expert Opin Ther Pat. 2017 Jul;27(7):851-866. DMA1RP9 RU https://www.ncbi.nlm.nih.gov/pubmed/28350212 DMH8GC6 DI DMH8GC6 DMH8GC6 DN PMID28350212-Compound-18 DMH8GC6 MI TTZS04O DMH8GC6 MN Gamma-secretase subunit APH-1A/1B (APH-1) DMH8GC6 MT DTT DMH8GC6 MA Inhibitor DMH8GC6 RN Gamma secretase inhibitors: a patent review (2013 - 2015).Expert Opin Ther Pat. 2017 Jul;27(7):851-866. DMH8GC6 RU https://www.ncbi.nlm.nih.gov/pubmed/28350212 DMI4US6 DI DMI4US6 DMI4US6 DN PMID28350212-Compound-19 DMI4US6 MI TTZS04O DMI4US6 MN Gamma-secretase subunit APH-1A/1B (APH-1) DMI4US6 MT DTT DMI4US6 MA Inhibitor DMI4US6 RN Gamma secretase inhibitors: a patent review (2013 - 2015).Expert Opin Ther Pat. 2017 Jul;27(7):851-866. DMI4US6 RU https://www.ncbi.nlm.nih.gov/pubmed/28350212 DMM5G7S DI DMM5G7S DMM5G7S DN PMID28350212-Compound-20 DMM5G7S MI TTZS04O DMM5G7S MN Gamma-secretase subunit APH-1A/1B (APH-1) DMM5G7S MT DTT DMM5G7S MA Inhibitor DMM5G7S RN Gamma secretase inhibitors: a patent review (2013 - 2015).Expert Opin Ther Pat. 2017 Jul;27(7):851-866. DMM5G7S RU https://www.ncbi.nlm.nih.gov/pubmed/28350212 DMFTGZC DI DMFTGZC DMFTGZC DN PMID28350212-Compound-21 DMFTGZC MI TTZS04O DMFTGZC MN Gamma-secretase subunit APH-1A/1B (APH-1) DMFTGZC MT DTT DMFTGZC MA Inhibitor DMFTGZC RN Gamma secretase inhibitors: a patent review (2013 - 2015).Expert Opin Ther Pat. 2017 Jul;27(7):851-866. DMFTGZC RU https://www.ncbi.nlm.nih.gov/pubmed/28350212 DMKXZYC DI DMKXZYC DMKXZYC DN PMID28350212-Compound-22 DMKXZYC MI TTZS04O DMKXZYC MN Gamma-secretase subunit APH-1A/1B (APH-1) DMKXZYC MT DTT DMKXZYC MA Inhibitor DMKXZYC RN Gamma secretase inhibitors: a patent review (2013 - 2015).Expert Opin Ther Pat. 2017 Jul;27(7):851-866. DMKXZYC RU https://www.ncbi.nlm.nih.gov/pubmed/28350212 DM3MVW1 DI DM3MVW1 DM3MVW1 DN PMID28350212-Compound-23 DM3MVW1 MI TTZS04O DM3MVW1 MN Gamma-secretase subunit APH-1A/1B (APH-1) DM3MVW1 MT DTT DM3MVW1 MA Inhibitor DM3MVW1 RN Gamma secretase inhibitors: a patent review (2013 - 2015).Expert Opin Ther Pat. 2017 Jul;27(7):851-866. DM3MVW1 RU https://www.ncbi.nlm.nih.gov/pubmed/28350212 DMPJH6L DI DMPJH6L DMPJH6L DN PMID28350212-Compound-24 DMPJH6L MI TTZS04O DMPJH6L MN Gamma-secretase subunit APH-1A/1B (APH-1) DMPJH6L MT DTT DMPJH6L MA Inhibitor DMPJH6L RN Gamma secretase inhibitors: a patent review (2013 - 2015).Expert Opin Ther Pat. 2017 Jul;27(7):851-866. DMPJH6L RU https://www.ncbi.nlm.nih.gov/pubmed/28350212 DML2VUC DI DML2VUC DML2VUC DN PMID28350212-Compound-25 DML2VUC MI TTZS04O DML2VUC MN Gamma-secretase subunit APH-1A/1B (APH-1) DML2VUC MT DTT DML2VUC MA Inhibitor DML2VUC RN Gamma secretase inhibitors: a patent review (2013 - 2015).Expert Opin Ther Pat. 2017 Jul;27(7):851-866. DML2VUC RU https://www.ncbi.nlm.nih.gov/pubmed/28350212 DMF1ZJ3 DI DMF1ZJ3 DMF1ZJ3 DN PMID28350212-Compound-30 DMF1ZJ3 MI TTZS04O DMF1ZJ3 MN Gamma-secretase subunit APH-1A/1B (APH-1) DMF1ZJ3 MT DTT DMF1ZJ3 MA Inhibitor DMF1ZJ3 RN Gamma secretase inhibitors: a patent review (2013 - 2015).Expert Opin Ther Pat. 2017 Jul;27(7):851-866. DMF1ZJ3 RU https://www.ncbi.nlm.nih.gov/pubmed/28350212 DMSKE2O DI DMSKE2O DMSKE2O DN PMID28350212-Compound-35 DMSKE2O MI TTZS04O DMSKE2O MN Gamma-secretase subunit APH-1A/1B (APH-1) DMSKE2O MT DTT DMSKE2O MA Inhibitor DMSKE2O RN Gamma secretase inhibitors: a patent review (2013 - 2015).Expert Opin Ther Pat. 2017 Jul;27(7):851-866. DMSKE2O RU https://www.ncbi.nlm.nih.gov/pubmed/28350212 DM7ULWD DI DM7ULWD DM7ULWD DN PMID28350212-Compound-36 DM7ULWD MI TTZS04O DM7ULWD MN Gamma-secretase subunit APH-1A/1B (APH-1) DM7ULWD MT DTT DM7ULWD MA Inhibitor DM7ULWD RN Gamma secretase inhibitors: a patent review (2013 - 2015).Expert Opin Ther Pat. 2017 Jul;27(7):851-866. DM7ULWD RU https://www.ncbi.nlm.nih.gov/pubmed/28350212 DMUBSFV DI DMUBSFV DMUBSFV DN PMID28350212-Compound-7 DMUBSFV MI TTZS04O DMUBSFV MN Gamma-secretase subunit APH-1A/1B (APH-1) DMUBSFV MT DTT DMUBSFV MA Inhibitor DMUBSFV RN Gamma secretase inhibitors: a patent review (2013 - 2015).Expert Opin Ther Pat. 2017 Jul;27(7):851-866. DMUBSFV RU https://www.ncbi.nlm.nih.gov/pubmed/28350212 DMR0PUA DI DMR0PUA DMR0PUA DN PMID28394193-Compound-10 DMR0PUA MI TTJBYRU DMR0PUA MN EZH2 Y641F mutant (EZH2 Y641F) DMR0PUA MT DTT DMR0PUA MA Inhibitor DMR0PUA RN EZH2 inhibitors: a patent review (2014-2016).Expert Opin Ther Pat. 2017 Jul;27(7):797-813. DMR0PUA RU https://www.ncbi.nlm.nih.gov/pubmed/28394193 DMJ23AL DI DMJ23AL DMJ23AL DN PMID28394193-Compound-11 DMJ23AL MI TTJBYRU DMJ23AL MN EZH2 Y641F mutant (EZH2 Y641F) DMJ23AL MT DTT DMJ23AL MA Inhibitor DMJ23AL RN EZH2 inhibitors: a patent review (2014-2016).Expert Opin Ther Pat. 2017 Jul;27(7):797-813. DMJ23AL RU https://www.ncbi.nlm.nih.gov/pubmed/28394193 DMA7H9T DI DMA7H9T DMA7H9T DN PMID28394193-Compound-12 DMA7H9T MI TT9MZCQ DMA7H9T MN Enhancer of zeste homolog 2 (EZH2) DMA7H9T MT DTT DMA7H9T MA Inhibitor DMA7H9T RN EZH2 inhibitors: a patent review (2014-2016).Expert Opin Ther Pat. 2017 Jul;27(7):797-813. DMA7H9T RU https://www.ncbi.nlm.nih.gov/pubmed/28394193 DMA7H9T DI DMA7H9T DMA7H9T DN PMID28394193-Compound-12 DMA7H9T MI TTJBYRU DMA7H9T MN EZH2 Y641F mutant (EZH2 Y641F) DMA7H9T MT DTT DMA7H9T MA Inhibitor DMA7H9T RN EZH2 inhibitors: a patent review (2014-2016).Expert Opin Ther Pat. 2017 Jul;27(7):797-813. DMA7H9T RU https://www.ncbi.nlm.nih.gov/pubmed/28394193 DMGZ9MW DI DMGZ9MW DMGZ9MW DN PMID28394193-Compound-13 DMGZ9MW MI TT9MZCQ DMGZ9MW MN Enhancer of zeste homolog 2 (EZH2) DMGZ9MW MT DTT DMGZ9MW MA Inhibitor DMGZ9MW RN EZH2 inhibitors: a patent review (2014-2016).Expert Opin Ther Pat. 2017 Jul;27(7):797-813. DMGZ9MW RU https://www.ncbi.nlm.nih.gov/pubmed/28394193 DMGZ9MW DI DMGZ9MW DMGZ9MW DN PMID28394193-Compound-13 DMGZ9MW MI TTJBYRU DMGZ9MW MN EZH2 Y641F mutant (EZH2 Y641F) DMGZ9MW MT DTT DMGZ9MW MA Inhibitor DMGZ9MW RN EZH2 inhibitors: a patent review (2014-2016).Expert Opin Ther Pat. 2017 Jul;27(7):797-813. DMGZ9MW RU https://www.ncbi.nlm.nih.gov/pubmed/28394193 DM6T2FM DI DM6T2FM DM6T2FM DN PMID28394193-Compound-14 DM6T2FM MI TT9MZCQ DM6T2FM MN Enhancer of zeste homolog 2 (EZH2) DM6T2FM MT DTT DM6T2FM MA Inhibitor DM6T2FM RN EZH2 inhibitors: a patent review (2014-2016).Expert Opin Ther Pat. 2017 Jul;27(7):797-813. DM6T2FM RU https://www.ncbi.nlm.nih.gov/pubmed/28394193 DM6T2FM DI DM6T2FM DM6T2FM DN PMID28394193-Compound-14 DM6T2FM MI TTJBYRU DM6T2FM MN EZH2 Y641F mutant (EZH2 Y641F) DM6T2FM MT DTT DM6T2FM MA Inhibitor DM6T2FM RN EZH2 inhibitors: a patent review (2014-2016).Expert Opin Ther Pat. 2017 Jul;27(7):797-813. DM6T2FM RU https://www.ncbi.nlm.nih.gov/pubmed/28394193 DMXMP92 DI DMXMP92 DMXMP92 DN PMID28394193-Compound-15 DMXMP92 MI TT9MZCQ DMXMP92 MN Enhancer of zeste homolog 2 (EZH2) DMXMP92 MT DTT DMXMP92 MA Inhibitor DMXMP92 RN EZH2 inhibitors: a patent review (2014-2016).Expert Opin Ther Pat. 2017 Jul;27(7):797-813. DMXMP92 RU https://www.ncbi.nlm.nih.gov/pubmed/28394193 DMQDRUT DI DMQDRUT DMQDRUT DN PMID28394193-Compound-16 DMQDRUT MI TT9MZCQ DMQDRUT MN Enhancer of zeste homolog 2 (EZH2) DMQDRUT MT DTT DMQDRUT MA Inhibitor DMQDRUT RN EZH2 inhibitors: a patent review (2014-2016).Expert Opin Ther Pat. 2017 Jul;27(7):797-813. DMQDRUT RU https://www.ncbi.nlm.nih.gov/pubmed/28394193 DMPR9GA DI DMPR9GA DMPR9GA DN PMID28394193-Compound-17 DMPR9GA MI TT9MZCQ DMPR9GA MN Enhancer of zeste homolog 2 (EZH2) DMPR9GA MT DTT DMPR9GA MA Inhibitor DMPR9GA RN EZH2 inhibitors: a patent review (2014-2016).Expert Opin Ther Pat. 2017 Jul;27(7):797-813. DMPR9GA RU https://www.ncbi.nlm.nih.gov/pubmed/28394193 DMIBZ2H DI DMIBZ2H DMIBZ2H DN PMID28394193-Compound-18 DMIBZ2H MI TT9MZCQ DMIBZ2H MN Enhancer of zeste homolog 2 (EZH2) DMIBZ2H MT DTT DMIBZ2H MA Inhibitor DMIBZ2H RN EZH2 inhibitors: a patent review (2014-2016).Expert Opin Ther Pat. 2017 Jul;27(7):797-813. DMIBZ2H RU https://www.ncbi.nlm.nih.gov/pubmed/28394193 DM4ZAE8 DI DM4ZAE8 DM4ZAE8 DN PMID28394193-Compound-19 DM4ZAE8 MI TT9MZCQ DM4ZAE8 MN Enhancer of zeste homolog 2 (EZH2) DM4ZAE8 MT DTT DM4ZAE8 MA Inhibitor DM4ZAE8 RN EZH2 inhibitors: a patent review (2014-2016).Expert Opin Ther Pat. 2017 Jul;27(7):797-813. DM4ZAE8 RU https://www.ncbi.nlm.nih.gov/pubmed/28394193 DMC5NR0 DI DMC5NR0 DMC5NR0 DN PMID28394193-Compound-20 DMC5NR0 MI TT9MZCQ DMC5NR0 MN Enhancer of zeste homolog 2 (EZH2) DMC5NR0 MT DTT DMC5NR0 MA Inhibitor DMC5NR0 RN EZH2 inhibitors: a patent review (2014-2016).Expert Opin Ther Pat. 2017 Jul;27(7):797-813. DMC5NR0 RU https://www.ncbi.nlm.nih.gov/pubmed/28394193 DMLD8K3 DI DMLD8K3 DMLD8K3 DN PMID28394193-Compound-21 DMLD8K3 MI TT9MZCQ DMLD8K3 MN Enhancer of zeste homolog 2 (EZH2) DMLD8K3 MT DTT DMLD8K3 MA Inhibitor DMLD8K3 RN EZH2 inhibitors: a patent review (2014-2016).Expert Opin Ther Pat. 2017 Jul;27(7):797-813. DMLD8K3 RU https://www.ncbi.nlm.nih.gov/pubmed/28394193 DM8PJ3F DI DM8PJ3F DM8PJ3F DN PMID28394193-Compound-22 DM8PJ3F MI TT9MZCQ DM8PJ3F MN Enhancer of zeste homolog 2 (EZH2) DM8PJ3F MT DTT DM8PJ3F MA Inhibitor DM8PJ3F RN EZH2 inhibitors: a patent review (2014-2016).Expert Opin Ther Pat. 2017 Jul;27(7):797-813. DM8PJ3F RU https://www.ncbi.nlm.nih.gov/pubmed/28394193 DMNHCMY DI DMNHCMY DMNHCMY DN PMID28394193-Compound-23 DMNHCMY MI TT9MZCQ DMNHCMY MN Enhancer of zeste homolog 2 (EZH2) DMNHCMY MT DTT DMNHCMY MA Inhibitor DMNHCMY RN EZH2 inhibitors: a patent review (2014-2016).Expert Opin Ther Pat. 2017 Jul;27(7):797-813. DMNHCMY RU https://www.ncbi.nlm.nih.gov/pubmed/28394193 DMYCVWZ DI DMYCVWZ DMYCVWZ DN PMID28394193-Compound-24 DMYCVWZ MI TT9MZCQ DMYCVWZ MN Enhancer of zeste homolog 2 (EZH2) DMYCVWZ MT DTT DMYCVWZ MA Inhibitor DMYCVWZ RN EZH2 inhibitors: a patent review (2014-2016).Expert Opin Ther Pat. 2017 Jul;27(7):797-813. DMYCVWZ RU https://www.ncbi.nlm.nih.gov/pubmed/28394193 DMPIXAO DI DMPIXAO DMPIXAO DN PMID28394193-Compound-25 DMPIXAO MI TT9MZCQ DMPIXAO MN Enhancer of zeste homolog 2 (EZH2) DMPIXAO MT DTT DMPIXAO MA Inhibitor DMPIXAO RN EZH2 inhibitors: a patent review (2014-2016).Expert Opin Ther Pat. 2017 Jul;27(7):797-813. DMPIXAO RU https://www.ncbi.nlm.nih.gov/pubmed/28394193 DMNWCUJ DI DMNWCUJ DMNWCUJ DN PMID28394193-Compound-26 DMNWCUJ MI TT9MZCQ DMNWCUJ MN Enhancer of zeste homolog 2 (EZH2) DMNWCUJ MT DTT DMNWCUJ MA Inhibitor DMNWCUJ RN EZH2 inhibitors: a patent review (2014-2016).Expert Opin Ther Pat. 2017 Jul;27(7):797-813. DMNWCUJ RU https://www.ncbi.nlm.nih.gov/pubmed/28394193 DM2KVDH DI DM2KVDH DM2KVDH DN PMID28394193-Compound-27 DM2KVDH MI TT9MZCQ DM2KVDH MN Enhancer of zeste homolog 2 (EZH2) DM2KVDH MT DTT DM2KVDH MA Inhibitor DM2KVDH RN EZH2 inhibitors: a patent review (2014-2016).Expert Opin Ther Pat. 2017 Jul;27(7):797-813. DM2KVDH RU https://www.ncbi.nlm.nih.gov/pubmed/28394193 DMC24OL DI DMC24OL DMC24OL DN PMID28394193-Compound-28 DMC24OL MI TT9MZCQ DMC24OL MN Enhancer of zeste homolog 2 (EZH2) DMC24OL MT DTT DMC24OL MA Inhibitor DMC24OL RN EZH2 inhibitors: a patent review (2014-2016).Expert Opin Ther Pat. 2017 Jul;27(7):797-813. DMC24OL RU https://www.ncbi.nlm.nih.gov/pubmed/28394193 DMBVI7L DI DMBVI7L DMBVI7L DN PMID28394193-Compound-29 DMBVI7L MI TT9MZCQ DMBVI7L MN Enhancer of zeste homolog 2 (EZH2) DMBVI7L MT DTT DMBVI7L MA Inhibitor DMBVI7L RN EZH2 inhibitors: a patent review (2014-2016).Expert Opin Ther Pat. 2017 Jul;27(7):797-813. DMBVI7L RU https://www.ncbi.nlm.nih.gov/pubmed/28394193 DMGEZT8 DI DMGEZT8 DMGEZT8 DN PMID28394193-Compound-30 DMGEZT8 MI TT9MZCQ DMGEZT8 MN Enhancer of zeste homolog 2 (EZH2) DMGEZT8 MT DTT DMGEZT8 MA Inhibitor DMGEZT8 RN EZH2 inhibitors: a patent review (2014-2016).Expert Opin Ther Pat. 2017 Jul;27(7):797-813. DMGEZT8 RU https://www.ncbi.nlm.nih.gov/pubmed/28394193 DMJ02N1 DI DMJ02N1 DMJ02N1 DN PMID28394193-Compound-31 DMJ02N1 MI TT9MZCQ DMJ02N1 MN Enhancer of zeste homolog 2 (EZH2) DMJ02N1 MT DTT DMJ02N1 MA Inhibitor DMJ02N1 RN EZH2 inhibitors: a patent review (2014-2016).Expert Opin Ther Pat. 2017 Jul;27(7):797-813. DMJ02N1 RU https://www.ncbi.nlm.nih.gov/pubmed/28394193 DM628MP DI DM628MP DM628MP DN PMID28394193-Compound-32 DM628MP MI TT9MZCQ DM628MP MN Enhancer of zeste homolog 2 (EZH2) DM628MP MT DTT DM628MP MA Inhibitor DM628MP RN EZH2 inhibitors: a patent review (2014-2016).Expert Opin Ther Pat. 2017 Jul;27(7):797-813. DM628MP RU https://www.ncbi.nlm.nih.gov/pubmed/28394193 DMEOHX2 DI DMEOHX2 DMEOHX2 DN PMID28394193-Compound-33 DMEOHX2 MI TT9MZCQ DMEOHX2 MN Enhancer of zeste homolog 2 (EZH2) DMEOHX2 MT DTT DMEOHX2 MA Inhibitor DMEOHX2 RN EZH2 inhibitors: a patent review (2014-2016).Expert Opin Ther Pat. 2017 Jul;27(7):797-813. DMEOHX2 RU https://www.ncbi.nlm.nih.gov/pubmed/28394193 DMB7WNP DI DMB7WNP DMB7WNP DN PMID28394193-Compound-34 DMB7WNP MI TT9MZCQ DMB7WNP MN Enhancer of zeste homolog 2 (EZH2) DMB7WNP MT DTT DMB7WNP MA Inhibitor DMB7WNP RN EZH2 inhibitors: a patent review (2014-2016).Expert Opin Ther Pat. 2017 Jul;27(7):797-813. DMB7WNP RU https://www.ncbi.nlm.nih.gov/pubmed/28394193 DMV1AGC DI DMV1AGC DMV1AGC DN PMID28394193-Compound-35 DMV1AGC MI TT9MZCQ DMV1AGC MN Enhancer of zeste homolog 2 (EZH2) DMV1AGC MT DTT DMV1AGC MA Inhibitor DMV1AGC RN EZH2 inhibitors: a patent review (2014-2016).Expert Opin Ther Pat. 2017 Jul;27(7):797-813. DMV1AGC RU https://www.ncbi.nlm.nih.gov/pubmed/28394193 DM658HJ DI DM658HJ DM658HJ DN PMID28394193-Compound-36 DM658HJ MI TT9MZCQ DM658HJ MN Enhancer of zeste homolog 2 (EZH2) DM658HJ MT DTT DM658HJ MA Inhibitor DM658HJ RN EZH2 inhibitors: a patent review (2014-2016).Expert Opin Ther Pat. 2017 Jul;27(7):797-813. DM658HJ RU https://www.ncbi.nlm.nih.gov/pubmed/28394193 DM73CA5 DI DM73CA5 DM73CA5 DN PMID28394193-Compound-37 DM73CA5 MI TT9MZCQ DM73CA5 MN Enhancer of zeste homolog 2 (EZH2) DM73CA5 MT DTT DM73CA5 MA Inhibitor DM73CA5 RN EZH2 inhibitors: a patent review (2014-2016).Expert Opin Ther Pat. 2017 Jul;27(7):797-813. DM73CA5 RU https://www.ncbi.nlm.nih.gov/pubmed/28394193 DM25PMQ DI DM25PMQ DM25PMQ DN PMID28394193-Compound-38 DM25PMQ MI TT9MZCQ DM25PMQ MN Enhancer of zeste homolog 2 (EZH2) DM25PMQ MT DTT DM25PMQ MA Inhibitor DM25PMQ RN EZH2 inhibitors: a patent review (2014-2016).Expert Opin Ther Pat. 2017 Jul;27(7):797-813. DM25PMQ RU https://www.ncbi.nlm.nih.gov/pubmed/28394193 DM2NS5T DI DM2NS5T DM2NS5T DN PMID28394193-Compound-39 DM2NS5T MI TT9MZCQ DM2NS5T MN Enhancer of zeste homolog 2 (EZH2) DM2NS5T MT DTT DM2NS5T MA Inhibitor DM2NS5T RN EZH2 inhibitors: a patent review (2014-2016).Expert Opin Ther Pat. 2017 Jul;27(7):797-813. DM2NS5T RU https://www.ncbi.nlm.nih.gov/pubmed/28394193 DMO5479 DI DMO5479 DMO5479 DN PMID28394193-Compound-40 DMO5479 MI TT9MZCQ DMO5479 MN Enhancer of zeste homolog 2 (EZH2) DMO5479 MT DTT DMO5479 MA Inhibitor DMO5479 RN EZH2 inhibitors: a patent review (2014-2016).Expert Opin Ther Pat. 2017 Jul;27(7):797-813. DMO5479 RU https://www.ncbi.nlm.nih.gov/pubmed/28394193 DMYLVTQ DI DMYLVTQ DMYLVTQ DN PMID28394193-Compound-41 DMYLVTQ MI TT9MZCQ DMYLVTQ MN Enhancer of zeste homolog 2 (EZH2) DMYLVTQ MT DTT DMYLVTQ MA Inhibitor DMYLVTQ RN EZH2 inhibitors: a patent review (2014-2016).Expert Opin Ther Pat. 2017 Jul;27(7):797-813. DMYLVTQ RU https://www.ncbi.nlm.nih.gov/pubmed/28394193 DMLI7TG DI DMLI7TG DMLI7TG DN PMID28394193-Compound-42 DMLI7TG MI TT9MZCQ DMLI7TG MN Enhancer of zeste homolog 2 (EZH2) DMLI7TG MT DTT DMLI7TG MA Inhibitor DMLI7TG RN EZH2 inhibitors: a patent review (2014-2016).Expert Opin Ther Pat. 2017 Jul;27(7):797-813. DMLI7TG RU https://www.ncbi.nlm.nih.gov/pubmed/28394193 DMASV8I DI DMASV8I DMASV8I DN PMID28394193-Compound-43 DMASV8I MI TT9MZCQ DMASV8I MN Enhancer of zeste homolog 2 (EZH2) DMASV8I MT DTT DMASV8I MA Inhibitor DMASV8I RN EZH2 inhibitors: a patent review (2014-2016).Expert Opin Ther Pat. 2017 Jul;27(7):797-813. DMASV8I RU https://www.ncbi.nlm.nih.gov/pubmed/28394193 DME6FWY DI DME6FWY DME6FWY DN PMID28394193-Compound-44 DME6FWY MI TT9MZCQ DME6FWY MN Enhancer of zeste homolog 2 (EZH2) DME6FWY MT DTT DME6FWY MA Inhibitor DME6FWY RN EZH2 inhibitors: a patent review (2014-2016).Expert Opin Ther Pat. 2017 Jul;27(7):797-813. DME6FWY RU https://www.ncbi.nlm.nih.gov/pubmed/28394193 DMZJXPF DI DMZJXPF DMZJXPF DN PMID28394193-Compound-45 DMZJXPF MI TT9MZCQ DMZJXPF MN Enhancer of zeste homolog 2 (EZH2) DMZJXPF MT DTT DMZJXPF MA Inhibitor DMZJXPF RN EZH2 inhibitors: a patent review (2014-2016).Expert Opin Ther Pat. 2017 Jul;27(7):797-813. DMZJXPF RU https://www.ncbi.nlm.nih.gov/pubmed/28394193 DMZJXPF DI DMZJXPF DMZJXPF DN PMID28394193-Compound-45 DMZJXPF MI TTJW2UQ DMZJXPF MN EZH2 Y641N mutant (EZH2 Y641N) DMZJXPF MT DTT DMZJXPF MA Inhibitor DMZJXPF RN EZH2 inhibitors: a patent review (2014-2016).Expert Opin Ther Pat. 2017 Jul;27(7):797-813. DMZJXPF RU https://www.ncbi.nlm.nih.gov/pubmed/28394193 DMYMPNA DI DMYMPNA DMYMPNA DN PMID28394193-Compound-46 DMYMPNA MI TT9MZCQ DMYMPNA MN Enhancer of zeste homolog 2 (EZH2) DMYMPNA MT DTT DMYMPNA MA Inhibitor DMYMPNA RN EZH2 inhibitors: a patent review (2014-2016).Expert Opin Ther Pat. 2017 Jul;27(7):797-813. DMYMPNA RU https://www.ncbi.nlm.nih.gov/pubmed/28394193 DMYMPNA DI DMYMPNA DMYMPNA DN PMID28394193-Compound-46 DMYMPNA MI TTJW2UQ DMYMPNA MN EZH2 Y641N mutant (EZH2 Y641N) DMYMPNA MT DTT DMYMPNA MA Inhibitor DMYMPNA RN EZH2 inhibitors: a patent review (2014-2016).Expert Opin Ther Pat. 2017 Jul;27(7):797-813. DMYMPNA RU https://www.ncbi.nlm.nih.gov/pubmed/28394193 DM7UDIM DI DM7UDIM DM7UDIM DN PMID28394193-Compound-47 DM7UDIM MI TT9MZCQ DM7UDIM MN Enhancer of zeste homolog 2 (EZH2) DM7UDIM MT DTT DM7UDIM MA Inhibitor DM7UDIM RN EZH2 inhibitors: a patent review (2014-2016).Expert Opin Ther Pat. 2017 Jul;27(7):797-813. DM7UDIM RU https://www.ncbi.nlm.nih.gov/pubmed/28394193 DMEU4Y1 DI DMEU4Y1 DMEU4Y1 DN PMID28394193-Compound-49 DMEU4Y1 MI TT9MZCQ DMEU4Y1 MN Enhancer of zeste homolog 2 (EZH2) DMEU4Y1 MT DTT DMEU4Y1 MA Inhibitor DMEU4Y1 RN EZH2 inhibitors: a patent review (2014-2016).Expert Opin Ther Pat. 2017 Jul;27(7):797-813. DMEU4Y1 RU https://www.ncbi.nlm.nih.gov/pubmed/28394193 DM4NVTB DI DM4NVTB DM4NVTB DN PMID28394193-Compound-50 DM4NVTB MI TT9MZCQ DM4NVTB MN Enhancer of zeste homolog 2 (EZH2) DM4NVTB MT DTT DM4NVTB MA Inhibitor DM4NVTB RN EZH2 inhibitors: a patent review (2014-2016).Expert Opin Ther Pat. 2017 Jul;27(7):797-813. DM4NVTB RU https://www.ncbi.nlm.nih.gov/pubmed/28394193 DM0KPQ9 DI DM0KPQ9 DM0KPQ9 DN PMID28394193-Compound-51 DM0KPQ9 MI TT9MZCQ DM0KPQ9 MN Enhancer of zeste homolog 2 (EZH2) DM0KPQ9 MT DTT DM0KPQ9 MA Inhibitor DM0KPQ9 RN EZH2 inhibitors: a patent review (2014-2016).Expert Opin Ther Pat. 2017 Jul;27(7):797-813. DM0KPQ9 RU https://www.ncbi.nlm.nih.gov/pubmed/28394193 DM2I9HY DI DM2I9HY DM2I9HY DN PMID28394193-Compound-52 DM2I9HY MI TT9MZCQ DM2I9HY MN Enhancer of zeste homolog 2 (EZH2) DM2I9HY MT DTT DM2I9HY MA Inhibitor DM2I9HY RN EZH2 inhibitors: a patent review (2014-2016).Expert Opin Ther Pat. 2017 Jul;27(7):797-813. DM2I9HY RU https://www.ncbi.nlm.nih.gov/pubmed/28394193 DMXMRQP DI DMXMRQP DMXMRQP DN PMID28394193-Compound-53 DMXMRQP MI TT9MZCQ DMXMRQP MN Enhancer of zeste homolog 2 (EZH2) DMXMRQP MT DTT DMXMRQP MA Inhibitor DMXMRQP RN EZH2 inhibitors: a patent review (2014-2016).Expert Opin Ther Pat. 2017 Jul;27(7):797-813. DMXMRQP RU https://www.ncbi.nlm.nih.gov/pubmed/28394193 DMMQ3UG DI DMMQ3UG DMMQ3UG DN PMID28394193-Compound-54 DMMQ3UG MI TT9MZCQ DMMQ3UG MN Enhancer of zeste homolog 2 (EZH2) DMMQ3UG MT DTT DMMQ3UG MA Inhibitor DMMQ3UG RN EZH2 inhibitors: a patent review (2014-2016).Expert Opin Ther Pat. 2017 Jul;27(7):797-813. DMMQ3UG RU https://www.ncbi.nlm.nih.gov/pubmed/28394193 DM2FPHZ DI DM2FPHZ DM2FPHZ DN PMID28394193-Compound-55 DM2FPHZ MI TT9MZCQ DM2FPHZ MN Enhancer of zeste homolog 2 (EZH2) DM2FPHZ MT DTT DM2FPHZ MA Inhibitor DM2FPHZ RN EZH2 inhibitors: a patent review (2014-2016).Expert Opin Ther Pat. 2017 Jul;27(7):797-813. DM2FPHZ RU https://www.ncbi.nlm.nih.gov/pubmed/28394193 DM2FPHZ DI DM2FPHZ DM2FPHZ DN PMID28394193-Compound-55 DM2FPHZ MI TTJW2UQ DM2FPHZ MN EZH2 Y641N mutant (EZH2 Y641N) DM2FPHZ MT DTT DM2FPHZ MA Inhibitor DM2FPHZ RN EZH2 inhibitors: a patent review (2014-2016).Expert Opin Ther Pat. 2017 Jul;27(7):797-813. DM2FPHZ RU https://www.ncbi.nlm.nih.gov/pubmed/28394193 DMQRFZK DI DMQRFZK DMQRFZK DN PMID28394193-Compound-56 DMQRFZK MI TT9MZCQ DMQRFZK MN Enhancer of zeste homolog 2 (EZH2) DMQRFZK MT DTT DMQRFZK MA Inhibitor DMQRFZK RN EZH2 inhibitors: a patent review (2014-2016).Expert Opin Ther Pat. 2017 Jul;27(7):797-813. DMQRFZK RU https://www.ncbi.nlm.nih.gov/pubmed/28394193 DMQRFZK DI DMQRFZK DMQRFZK DN PMID28394193-Compound-56 DMQRFZK MI TTJW2UQ DMQRFZK MN EZH2 Y641N mutant (EZH2 Y641N) DMQRFZK MT DTT DMQRFZK MA Inhibitor DMQRFZK RN EZH2 inhibitors: a patent review (2014-2016).Expert Opin Ther Pat. 2017 Jul;27(7):797-813. DMQRFZK RU https://www.ncbi.nlm.nih.gov/pubmed/28394193 DM4Y3US DI DM4Y3US DM4Y3US DN PMID28394193-Compound-57 DM4Y3US MI TT9MZCQ DM4Y3US MN Enhancer of zeste homolog 2 (EZH2) DM4Y3US MT DTT DM4Y3US MA Inhibitor DM4Y3US RN EZH2 inhibitors: a patent review (2014-2016).Expert Opin Ther Pat. 2017 Jul;27(7):797-813. DM4Y3US RU https://www.ncbi.nlm.nih.gov/pubmed/28394193 DM4Y3US DI DM4Y3US DM4Y3US DN PMID28394193-Compound-57 DM4Y3US MI TTJW2UQ DM4Y3US MN EZH2 Y641N mutant (EZH2 Y641N) DM4Y3US MT DTT DM4Y3US MA Inhibitor DM4Y3US RN EZH2 inhibitors: a patent review (2014-2016).Expert Opin Ther Pat. 2017 Jul;27(7):797-813. DM4Y3US RU https://www.ncbi.nlm.nih.gov/pubmed/28394193 DMXK2GA DI DMXK2GA DMXK2GA DN PMID28394193-Compound-Figure3bI DMXK2GA MI TT9MZCQ DMXK2GA MN Enhancer of zeste homolog 2 (EZH2) DMXK2GA MT DTT DMXK2GA MA Inhibitor DMXK2GA RN EZH2 inhibitors: a patent review (2014-2016).Expert Opin Ther Pat. 2017 Jul;27(7):797-813. DMXK2GA RU https://www.ncbi.nlm.nih.gov/pubmed/28394193 DML6PE0 DI DML6PE0 DML6PE0 DN PMID28394193-Compound-Figure3bII DML6PE0 MI TT9MZCQ DML6PE0 MN Enhancer of zeste homolog 2 (EZH2) DML6PE0 MT DTT DML6PE0 MA Inhibitor DML6PE0 RN EZH2 inhibitors: a patent review (2014-2016).Expert Opin Ther Pat. 2017 Jul;27(7):797-813. DML6PE0 RU https://www.ncbi.nlm.nih.gov/pubmed/28394193 DMUI385 DI DMUI385 DMUI385 DN PMID28394193-Compound-Figure3bIII DMUI385 MI TT9MZCQ DMUI385 MN Enhancer of zeste homolog 2 (EZH2) DMUI385 MT DTT DMUI385 MA Inhibitor DMUI385 RN EZH2 inhibitors: a patent review (2014-2016).Expert Opin Ther Pat. 2017 Jul;27(7):797-813. DMUI385 RU https://www.ncbi.nlm.nih.gov/pubmed/28394193 DMKVRTM DI DMKVRTM DMKVRTM DN PMID28394193-Compound-Figure5aVIII DMKVRTM MI TT9MZCQ DMKVRTM MN Enhancer of zeste homolog 2 (EZH2) DMKVRTM MT DTT DMKVRTM MA Inhibitor DMKVRTM RN EZH2 inhibitors: a patent review (2014-2016).Expert Opin Ther Pat. 2017 Jul;27(7):797-813. DMKVRTM RU https://www.ncbi.nlm.nih.gov/pubmed/28394193 DMA7OEF DI DMA7OEF DMA7OEF DN PMID28447479-Compound-10 DMA7OEF MI TTSCIM2 DMA7OEF MN Extracellular lysophospholipase D (E-NPP2) DMA7OEF MT DTT DMA7OEF MA Inhibitor DMA7OEF RN Autotaxin inhibitors: a patent review (2012-2016).Expert Opin Ther Pat. 2017 Jul;27(7):815-829. DMA7OEF RU https://www.ncbi.nlm.nih.gov/pubmed/28447479 DMOYMWZ DI DMOYMWZ DMOYMWZ DN PMID28447479-Compound-11 DMOYMWZ MI TTSCIM2 DMOYMWZ MN Extracellular lysophospholipase D (E-NPP2) DMOYMWZ MT DTT DMOYMWZ MA Inhibitor DMOYMWZ RN Autotaxin inhibitors: a patent review (2012-2016).Expert Opin Ther Pat. 2017 Jul;27(7):815-829. DMOYMWZ RU https://www.ncbi.nlm.nih.gov/pubmed/28447479 DMA91X2 DI DMA91X2 DMA91X2 DN PMID28447479-Compound-14 DMA91X2 MI TTSCIM2 DMA91X2 MN Extracellular lysophospholipase D (E-NPP2) DMA91X2 MT DTT DMA91X2 MA Inhibitor DMA91X2 RN Autotaxin inhibitors: a patent review (2012-2016).Expert Opin Ther Pat. 2017 Jul;27(7):815-829. DMA91X2 RU https://www.ncbi.nlm.nih.gov/pubmed/28447479 DMWSL5G DI DMWSL5G DMWSL5G DN PMID28447479-Compound-20 DMWSL5G MI TTSCIM2 DMWSL5G MN Extracellular lysophospholipase D (E-NPP2) DMWSL5G MT DTT DMWSL5G MA Inhibitor DMWSL5G RN Autotaxin inhibitors: a patent review (2012-2016).Expert Opin Ther Pat. 2017 Jul;27(7):815-829. DMWSL5G RU https://www.ncbi.nlm.nih.gov/pubmed/28447479 DM8PET6 DI DM8PET6 DM8PET6 DN PMID28447479-Compound-21 DM8PET6 MI TTSCIM2 DM8PET6 MN Extracellular lysophospholipase D (E-NPP2) DM8PET6 MT DTT DM8PET6 MA Inhibitor DM8PET6 RN Autotaxin inhibitors: a patent review (2012-2016).Expert Opin Ther Pat. 2017 Jul;27(7):815-829. DM8PET6 RU https://www.ncbi.nlm.nih.gov/pubmed/28447479 DMRCM1O DI DMRCM1O DMRCM1O DN PMID28447479-Compound-22 DMRCM1O MI TTSCIM2 DMRCM1O MN Extracellular lysophospholipase D (E-NPP2) DMRCM1O MT DTT DMRCM1O RN Autotaxin inhibitors: a patent review (2012-2016).Expert Opin Ther Pat. 2017 Jul;27(7):815-829. DMRCM1O RU https://www.ncbi.nlm.nih.gov/pubmed/28447479 DMM0BVE DI DMM0BVE DMM0BVE DN PMID28447479-Compound-23 DMM0BVE MI TTSCIM2 DMM0BVE MN Extracellular lysophospholipase D (E-NPP2) DMM0BVE MT DTT DMM0BVE RN Autotaxin inhibitors: a patent review (2012-2016).Expert Opin Ther Pat. 2017 Jul;27(7):815-829. DMM0BVE RU https://www.ncbi.nlm.nih.gov/pubmed/28447479 DMDOVIZ DI DMDOVIZ DMDOVIZ DN PMID28447479-Compound-24 DMDOVIZ MI TTSCIM2 DMDOVIZ MN Extracellular lysophospholipase D (E-NPP2) DMDOVIZ MT DTT DMDOVIZ RN Autotaxin inhibitors: a patent review (2012-2016).Expert Opin Ther Pat. 2017 Jul;27(7):815-829. DMDOVIZ RU https://www.ncbi.nlm.nih.gov/pubmed/28447479 DMJZSWF DI DMJZSWF DMJZSWF DN PMID28447479-Compound-26 DMJZSWF MI TTSCIM2 DMJZSWF MN Extracellular lysophospholipase D (E-NPP2) DMJZSWF MT DTT DMJZSWF MA Agonist DMJZSWF RN Autotaxin inhibitors: a patent review (2012-2016).Expert Opin Ther Pat. 2017 Jul;27(7):815-829. DMJZSWF RU https://www.ncbi.nlm.nih.gov/pubmed/28447479 DMVZPIO DI DMVZPIO DMVZPIO DN PMID28447479-Compound-27 DMVZPIO MI TTSCIM2 DMVZPIO MN Extracellular lysophospholipase D (E-NPP2) DMVZPIO MT DTT DMVZPIO MA Agonist DMVZPIO RN Autotaxin inhibitors: a patent review (2012-2016).Expert Opin Ther Pat. 2017 Jul;27(7):815-829. DMVZPIO RU https://www.ncbi.nlm.nih.gov/pubmed/28447479 DMUBM1Y DI DMUBM1Y DMUBM1Y DN PMID28447479-Compound-4 DMUBM1Y MI TTSCIM2 DMUBM1Y MN Extracellular lysophospholipase D (E-NPP2) DMUBM1Y MT DTT DMUBM1Y MA Inhibitor DMUBM1Y RN Autotaxin inhibitors: a patent review (2012-2016).Expert Opin Ther Pat. 2017 Jul;27(7):815-829. DMUBM1Y RU https://www.ncbi.nlm.nih.gov/pubmed/28447479 DMD9W6H DI DMD9W6H DMD9W6H DN PMID28454500-Compound-10 DMD9W6H MI TT3Z6Y9 DMD9W6H MN Cysteines of Keap1 (KEAP1 Cysteines) DMD9W6H MT DTT DMD9W6H MA Modulator DMD9W6H RN Recent progress in the development of small molecule Nrf2 modulators: a patent review (2012-2016).Expert Opin Ther Pat. 2017 Jul;27(7):763-785. DMD9W6H RU https://www.ncbi.nlm.nih.gov/pubmed/28454500 DMD9W6H DI DMD9W6H DMD9W6H DN PMID28454500-Compound-10 DMD9W6H MI TTA6ZN2 DMD9W6H MN Nuclear factor erythroid 2-related factor 2 (Nrf2) DMD9W6H MT DTT DMD9W6H MA Activator DMD9W6H RN Recent progress in the development of small molecule Nrf2 modulators: a patent review (2012-2016).Expert Opin Ther Pat. 2017 Jul;27(7):763-785. DMD9W6H RU https://www.ncbi.nlm.nih.gov/pubmed/28454500 DM1ZFC9 DI DM1ZFC9 DM1ZFC9 DN PMID28454500-Compound-11 DM1ZFC9 MI TT3Z6Y9 DM1ZFC9 MN Cysteines of Keap1 (KEAP1 Cysteines) DM1ZFC9 MT DTT DM1ZFC9 MA Modulator DM1ZFC9 RN Recent progress in the development of small molecule Nrf2 modulators: a patent review (2012-2016).Expert Opin Ther Pat. 2017 Jul;27(7):763-785. DM1ZFC9 RU https://www.ncbi.nlm.nih.gov/pubmed/28454500 DM1ZFC9 DI DM1ZFC9 DM1ZFC9 DN PMID28454500-Compound-11 DM1ZFC9 MI TTA6ZN2 DM1ZFC9 MN Nuclear factor erythroid 2-related factor 2 (Nrf2) DM1ZFC9 MT DTT DM1ZFC9 MA Activator DM1ZFC9 RN Recent progress in the development of small molecule Nrf2 modulators: a patent review (2012-2016).Expert Opin Ther Pat. 2017 Jul;27(7):763-785. DM1ZFC9 RU https://www.ncbi.nlm.nih.gov/pubmed/28454500 DMUY4LS DI DMUY4LS DMUY4LS DN PMID28454500-Compound-12 DMUY4LS MI TT3Z6Y9 DMUY4LS MN Cysteines of Keap1 (KEAP1 Cysteines) DMUY4LS MT DTT DMUY4LS MA Modulator DMUY4LS RN Recent progress in the development of small molecule Nrf2 modulators: a patent review (2012-2016).Expert Opin Ther Pat. 2017 Jul;27(7):763-785. DMUY4LS RU https://www.ncbi.nlm.nih.gov/pubmed/28454500 DMUY4LS DI DMUY4LS DMUY4LS DN PMID28454500-Compound-12 DMUY4LS MI TTA6ZN2 DMUY4LS MN Nuclear factor erythroid 2-related factor 2 (Nrf2) DMUY4LS MT DTT DMUY4LS MA Activator DMUY4LS RN Recent progress in the development of small molecule Nrf2 modulators: a patent review (2012-2016).Expert Opin Ther Pat. 2017 Jul;27(7):763-785. DMUY4LS RU https://www.ncbi.nlm.nih.gov/pubmed/28454500 DM7SIVA DI DM7SIVA DM7SIVA DN PMID28454500-Compound-13 DM7SIVA MI TT3Z6Y9 DM7SIVA MN Cysteines of Keap1 (KEAP1 Cysteines) DM7SIVA MT DTT DM7SIVA MA Modulator DM7SIVA RN Recent progress in the development of small molecule Nrf2 modulators: a patent review (2012-2016).Expert Opin Ther Pat. 2017 Jul;27(7):763-785. DM7SIVA RU https://www.ncbi.nlm.nih.gov/pubmed/28454500 DM7SIVA DI DM7SIVA DM7SIVA DN PMID28454500-Compound-13 DM7SIVA MI TTA6ZN2 DM7SIVA MN Nuclear factor erythroid 2-related factor 2 (Nrf2) DM7SIVA MT DTT DM7SIVA MA Activator DM7SIVA RN Recent progress in the development of small molecule Nrf2 modulators: a patent review (2012-2016).Expert Opin Ther Pat. 2017 Jul;27(7):763-785. DM7SIVA RU https://www.ncbi.nlm.nih.gov/pubmed/28454500 DMAGVHX DI DMAGVHX DMAGVHX DN PMID28454500-Compound-3 DMAGVHX MI TT3Z6Y9 DMAGVHX MN Cysteines of Keap1 (KEAP1 Cysteines) DMAGVHX MT DTT DMAGVHX MA Modulator DMAGVHX RN Recent progress in the development of small molecule Nrf2 modulators: a patent review (2012-2016).Expert Opin Ther Pat. 2017 Jul;27(7):763-785. DMAGVHX RU https://www.ncbi.nlm.nih.gov/pubmed/28454500 DMAGVHX DI DMAGVHX DMAGVHX DN PMID28454500-Compound-3 DMAGVHX MI TTA6ZN2 DMAGVHX MN Nuclear factor erythroid 2-related factor 2 (Nrf2) DMAGVHX MT DTT DMAGVHX MA Activator DMAGVHX RN Recent progress in the development of small molecule Nrf2 modulators: a patent review (2012-2016).Expert Opin Ther Pat. 2017 Jul;27(7):763-785. DMAGVHX RU https://www.ncbi.nlm.nih.gov/pubmed/28454500 DMAIGJP DI DMAIGJP DMAIGJP DN PMID28454500-Compound-32 DMAIGJP MI TT3Z6Y9 DMAIGJP MN Cysteines of Keap1 (KEAP1 Cysteines) DMAIGJP MT DTT DMAIGJP MA Modulator DMAIGJP RN Recent progress in the development of small molecule Nrf2 modulators: a patent review (2012-2016).Expert Opin Ther Pat. 2017 Jul;27(7):763-785. DMAIGJP RU https://www.ncbi.nlm.nih.gov/pubmed/28454500 DMAIGJP DI DMAIGJP DMAIGJP DN PMID28454500-Compound-32 DMAIGJP MI TTA6ZN2 DMAIGJP MN Nuclear factor erythroid 2-related factor 2 (Nrf2) DMAIGJP MT DTT DMAIGJP MA Activator DMAIGJP RN Recent progress in the development of small molecule Nrf2 modulators: a patent review (2012-2016).Expert Opin Ther Pat. 2017 Jul;27(7):763-785. DMAIGJP RU https://www.ncbi.nlm.nih.gov/pubmed/28454500 DMYXQU3 DI DMYXQU3 DMYXQU3 DN PMID28454500-Compound-33 DMYXQU3 MI TT3Z6Y9 DMYXQU3 MN Cysteines of Keap1 (KEAP1 Cysteines) DMYXQU3 MT DTT DMYXQU3 MA Modulator DMYXQU3 RN Recent progress in the development of small molecule Nrf2 modulators: a patent review (2012-2016).Expert Opin Ther Pat. 2017 Jul;27(7):763-785. DMYXQU3 RU https://www.ncbi.nlm.nih.gov/pubmed/28454500 DMYXQU3 DI DMYXQU3 DMYXQU3 DN PMID28454500-Compound-33 DMYXQU3 MI TTA6ZN2 DMYXQU3 MN Nuclear factor erythroid 2-related factor 2 (Nrf2) DMYXQU3 MT DTT DMYXQU3 MA Activator DMYXQU3 RN Recent progress in the development of small molecule Nrf2 modulators: a patent review (2012-2016).Expert Opin Ther Pat. 2017 Jul;27(7):763-785. DMYXQU3 RU https://www.ncbi.nlm.nih.gov/pubmed/28454500 DMN2910 DI DMN2910 DMN2910 DN PMID28454500-Compound-34 DMN2910 MI TT3Z6Y9 DMN2910 MN Cysteines of Keap1 (KEAP1 Cysteines) DMN2910 MT DTT DMN2910 MA Modulator DMN2910 RN Recent progress in the development of small molecule Nrf2 modulators: a patent review (2012-2016).Expert Opin Ther Pat. 2017 Jul;27(7):763-785. DMN2910 RU https://www.ncbi.nlm.nih.gov/pubmed/28454500 DMN2910 DI DMN2910 DMN2910 DN PMID28454500-Compound-34 DMN2910 MI TTA6ZN2 DMN2910 MN Nuclear factor erythroid 2-related factor 2 (Nrf2) DMN2910 MT DTT DMN2910 MA Activator DMN2910 RN Recent progress in the development of small molecule Nrf2 modulators: a patent review (2012-2016).Expert Opin Ther Pat. 2017 Jul;27(7):763-785. DMN2910 RU https://www.ncbi.nlm.nih.gov/pubmed/28454500 DM2OM4Z DI DM2OM4Z DM2OM4Z DN PMID28454500-Compound-35 DM2OM4Z MI TT3Z6Y9 DM2OM4Z MN Cysteines of Keap1 (KEAP1 Cysteines) DM2OM4Z MT DTT DM2OM4Z MA Modulator DM2OM4Z RN Recent progress in the development of small molecule Nrf2 modulators: a patent review (2012-2016).Expert Opin Ther Pat. 2017 Jul;27(7):763-785. DM2OM4Z RU https://www.ncbi.nlm.nih.gov/pubmed/28454500 DM2OM4Z DI DM2OM4Z DM2OM4Z DN PMID28454500-Compound-35 DM2OM4Z MI TTA6ZN2 DM2OM4Z MN Nuclear factor erythroid 2-related factor 2 (Nrf2) DM2OM4Z MT DTT DM2OM4Z MA Activator DM2OM4Z RN Recent progress in the development of small molecule Nrf2 modulators: a patent review (2012-2016).Expert Opin Ther Pat. 2017 Jul;27(7):763-785. DM2OM4Z RU https://www.ncbi.nlm.nih.gov/pubmed/28454500 DM5RZWG DI DM5RZWG DM5RZWG DN PMID28454500-Compound-36 DM5RZWG MI TT3Z6Y9 DM5RZWG MN Cysteines of Keap1 (KEAP1 Cysteines) DM5RZWG MT DTT DM5RZWG MA Modulator DM5RZWG RN Recent progress in the development of small molecule Nrf2 modulators: a patent review (2012-2016).Expert Opin Ther Pat. 2017 Jul;27(7):763-785. DM5RZWG RU https://www.ncbi.nlm.nih.gov/pubmed/28454500 DM5RZWG DI DM5RZWG DM5RZWG DN PMID28454500-Compound-36 DM5RZWG MI TTA6ZN2 DM5RZWG MN Nuclear factor erythroid 2-related factor 2 (Nrf2) DM5RZWG MT DTT DM5RZWG MA Activator DM5RZWG RN Recent progress in the development of small molecule Nrf2 modulators: a patent review (2012-2016).Expert Opin Ther Pat. 2017 Jul;27(7):763-785. DM5RZWG RU https://www.ncbi.nlm.nih.gov/pubmed/28454500 DM83P6H DI DM83P6H DM83P6H DN PMID28454500-Compound-37 DM83P6H MI TT3Z6Y9 DM83P6H MN Cysteines of Keap1 (KEAP1 Cysteines) DM83P6H MT DTT DM83P6H MA Modulator DM83P6H RN Recent progress in the development of small molecule Nrf2 modulators: a patent review (2012-2016).Expert Opin Ther Pat. 2017 Jul;27(7):763-785. DM83P6H RU https://www.ncbi.nlm.nih.gov/pubmed/28454500 DM83P6H DI DM83P6H DM83P6H DN PMID28454500-Compound-37 DM83P6H MI TTA6ZN2 DM83P6H MN Nuclear factor erythroid 2-related factor 2 (Nrf2) DM83P6H MT DTT DM83P6H MA Activator DM83P6H RN Recent progress in the development of small molecule Nrf2 modulators: a patent review (2012-2016).Expert Opin Ther Pat. 2017 Jul;27(7):763-785. DM83P6H RU https://www.ncbi.nlm.nih.gov/pubmed/28454500 DM9TVWJ DI DM9TVWJ DM9TVWJ DN PMID28454500-Compound-40 DM9TVWJ MI TT3Z6Y9 DM9TVWJ MN Cysteines of Keap1 (KEAP1 Cysteines) DM9TVWJ MT DTT DM9TVWJ MA Modulator DM9TVWJ RN Recent progress in the development of small molecule Nrf2 modulators: a patent review (2012-2016).Expert Opin Ther Pat. 2017 Jul;27(7):763-785. DM9TVWJ RU https://www.ncbi.nlm.nih.gov/pubmed/28454500 DM9TVWJ DI DM9TVWJ DM9TVWJ DN PMID28454500-Compound-40 DM9TVWJ MI TTA6ZN2 DM9TVWJ MN Nuclear factor erythroid 2-related factor 2 (Nrf2) DM9TVWJ MT DTT DM9TVWJ MA Activator DM9TVWJ RN Recent progress in the development of small molecule Nrf2 modulators: a patent review (2012-2016).Expert Opin Ther Pat. 2017 Jul;27(7):763-785. DM9TVWJ RU https://www.ncbi.nlm.nih.gov/pubmed/28454500 DMGAW81 DI DMGAW81 DMGAW81 DN PMID28454500-Compound-41 DMGAW81 MI TT3Z6Y9 DMGAW81 MN Cysteines of Keap1 (KEAP1 Cysteines) DMGAW81 MT DTT DMGAW81 MA Modulator DMGAW81 RN Recent progress in the development of small molecule Nrf2 modulators: a patent review (2012-2016).Expert Opin Ther Pat. 2017 Jul;27(7):763-785. DMGAW81 RU https://www.ncbi.nlm.nih.gov/pubmed/28454500 DMGAW81 DI DMGAW81 DMGAW81 DN PMID28454500-Compound-41 DMGAW81 MI TTA6ZN2 DMGAW81 MN Nuclear factor erythroid 2-related factor 2 (Nrf2) DMGAW81 MT DTT DMGAW81 MA Activator DMGAW81 RN Recent progress in the development of small molecule Nrf2 modulators: a patent review (2012-2016).Expert Opin Ther Pat. 2017 Jul;27(7):763-785. DMGAW81 RU https://www.ncbi.nlm.nih.gov/pubmed/28454500 DM5NJDK DI DM5NJDK DM5NJDK DN PMID28454500-Compound-49 DM5NJDK MI TT3Z6Y9 DM5NJDK MN Cysteines of Keap1 (KEAP1 Cysteines) DM5NJDK MT DTT DM5NJDK MA Modulator DM5NJDK RN Recent progress in the development of small molecule Nrf2 modulators: a patent review (2012-2016).Expert Opin Ther Pat. 2017 Jul;27(7):763-785. DM5NJDK RU https://www.ncbi.nlm.nih.gov/pubmed/28454500 DM5NJDK DI DM5NJDK DM5NJDK DN PMID28454500-Compound-49 DM5NJDK MI TTA6ZN2 DM5NJDK MN Nuclear factor erythroid 2-related factor 2 (Nrf2) DM5NJDK MT DTT DM5NJDK MA Activator DM5NJDK RN Recent progress in the development of small molecule Nrf2 modulators: a patent review (2012-2016).Expert Opin Ther Pat. 2017 Jul;27(7):763-785. DM5NJDK RU https://www.ncbi.nlm.nih.gov/pubmed/28454500 DMQPKCD DI DMQPKCD DMQPKCD DN PMID28454500-Compound-50 DMQPKCD MI TT3Z6Y9 DMQPKCD MN Cysteines of Keap1 (KEAP1 Cysteines) DMQPKCD MT DTT DMQPKCD MA Modulator DMQPKCD RN Recent progress in the development of small molecule Nrf2 modulators: a patent review (2012-2016).Expert Opin Ther Pat. 2017 Jul;27(7):763-785. DMQPKCD RU https://www.ncbi.nlm.nih.gov/pubmed/28454500 DMQPKCD DI DMQPKCD DMQPKCD DN PMID28454500-Compound-50 DMQPKCD MI TTA6ZN2 DMQPKCD MN Nuclear factor erythroid 2-related factor 2 (Nrf2) DMQPKCD MT DTT DMQPKCD MA Activator DMQPKCD RN Recent progress in the development of small molecule Nrf2 modulators: a patent review (2012-2016).Expert Opin Ther Pat. 2017 Jul;27(7):763-785. DMQPKCD RU https://www.ncbi.nlm.nih.gov/pubmed/28454500 DMTK9M6 DI DMTK9M6 DMTK9M6 DN PMID28454500-Compound-57 DMTK9M6 MI TTGIZLN DMTK9M6 MN Keap1-Nrf2[dual DLG and ETGE] PPI (KEAP1-Nrf2 DLG and ETGE) DMTK9M6 MT DTT DMTK9M6 MA Modulator DMTK9M6 RN Recent progress in the development of small molecule Nrf2 modulators: a patent review (2012-2016).Expert Opin Ther Pat. 2017 Jul;27(7):763-785. DMTK9M6 RU https://www.ncbi.nlm.nih.gov/pubmed/28454500 DMTK9M6 DI DMTK9M6 DMTK9M6 DN PMID28454500-Compound-57 DMTK9M6 MI TTA6ZN2 DMTK9M6 MN Nuclear factor erythroid 2-related factor 2 (Nrf2) DMTK9M6 MT DTT DMTK9M6 MA Inhibitor DMTK9M6 RN Recent progress in the development of small molecule Nrf2 modulators: a patent review (2012-2016).Expert Opin Ther Pat. 2017 Jul;27(7):763-785. DMTK9M6 RU https://www.ncbi.nlm.nih.gov/pubmed/28454500 DMDEHYR DI DMDEHYR DMDEHYR DN PMID28454500-Compound-58 DMDEHYR MI TTGIZLN DMDEHYR MN Keap1-Nrf2[dual DLG and ETGE] PPI (KEAP1-Nrf2 DLG and ETGE) DMDEHYR MT DTT DMDEHYR MA Modulator DMDEHYR RN Recent progress in the development of small molecule Nrf2 modulators: a patent review (2012-2016).Expert Opin Ther Pat. 2017 Jul;27(7):763-785. DMDEHYR RU https://www.ncbi.nlm.nih.gov/pubmed/28454500 DMDEHYR DI DMDEHYR DMDEHYR DN PMID28454500-Compound-58 DMDEHYR MI TTA6ZN2 DMDEHYR MN Nuclear factor erythroid 2-related factor 2 (Nrf2) DMDEHYR MT DTT DMDEHYR MA Inhibitor DMDEHYR RN Recent progress in the development of small molecule Nrf2 modulators: a patent review (2012-2016).Expert Opin Ther Pat. 2017 Jul;27(7):763-785. DMDEHYR RU https://www.ncbi.nlm.nih.gov/pubmed/28454500 DMQWPSF DI DMQWPSF DMQWPSF DN PMID28454500-Compound-59 DMQWPSF MI TTGIZLN DMQWPSF MN Keap1-Nrf2[dual DLG and ETGE] PPI (KEAP1-Nrf2 DLG and ETGE) DMQWPSF MT DTT DMQWPSF MA Modulator DMQWPSF RN Recent progress in the development of small molecule Nrf2 modulators: a patent review (2012-2016).Expert Opin Ther Pat. 2017 Jul;27(7):763-785. DMQWPSF RU https://www.ncbi.nlm.nih.gov/pubmed/28454500 DMQWPSF DI DMQWPSF DMQWPSF DN PMID28454500-Compound-59 DMQWPSF MI TTA6ZN2 DMQWPSF MN Nuclear factor erythroid 2-related factor 2 (Nrf2) DMQWPSF MT DTT DMQWPSF MA Inhibitor DMQWPSF RN Recent progress in the development of small molecule Nrf2 modulators: a patent review (2012-2016).Expert Opin Ther Pat. 2017 Jul;27(7):763-785. DMQWPSF RU https://www.ncbi.nlm.nih.gov/pubmed/28454500 DM1I9JC DI DM1I9JC DM1I9JC DN PMID28454500-Compound-60 DM1I9JC MI TTGIZLN DM1I9JC MN Keap1-Nrf2[dual DLG and ETGE] PPI (KEAP1-Nrf2 DLG and ETGE) DM1I9JC MT DTT DM1I9JC MA Modulator DM1I9JC RN Recent progress in the development of small molecule Nrf2 modulators: a patent review (2012-2016).Expert Opin Ther Pat. 2017 Jul;27(7):763-785. DM1I9JC RU https://www.ncbi.nlm.nih.gov/pubmed/28454500 DM1I9JC DI DM1I9JC DM1I9JC DN PMID28454500-Compound-60 DM1I9JC MI TTA6ZN2 DM1I9JC MN Nuclear factor erythroid 2-related factor 2 (Nrf2) DM1I9JC MT DTT DM1I9JC MA Inhibitor DM1I9JC RN Recent progress in the development of small molecule Nrf2 modulators: a patent review (2012-2016).Expert Opin Ther Pat. 2017 Jul;27(7):763-785. DM1I9JC RU https://www.ncbi.nlm.nih.gov/pubmed/28454500 DM6BQFA DI DM6BQFA DM6BQFA DN PMID28454500-Compound-8 DM6BQFA MI TT3Z6Y9 DM6BQFA MN Cysteines of Keap1 (KEAP1 Cysteines) DM6BQFA MT DTT DM6BQFA MA Modulator DM6BQFA RN Recent progress in the development of small molecule Nrf2 modulators: a patent review (2012-2016).Expert Opin Ther Pat. 2017 Jul;27(7):763-785. DM6BQFA RU https://www.ncbi.nlm.nih.gov/pubmed/28454500 DM6BQFA DI DM6BQFA DM6BQFA DN PMID28454500-Compound-8 DM6BQFA MI TTA6ZN2 DM6BQFA MN Nuclear factor erythroid 2-related factor 2 (Nrf2) DM6BQFA MT DTT DM6BQFA MA Activator DM6BQFA RN Recent progress in the development of small molecule Nrf2 modulators: a patent review (2012-2016).Expert Opin Ther Pat. 2017 Jul;27(7):763-785. DM6BQFA RU https://www.ncbi.nlm.nih.gov/pubmed/28454500 DM3HR7F DI DM3HR7F DM3HR7F DN PMID28454500-Compound-9 DM3HR7F MI TT3Z6Y9 DM3HR7F MN Cysteines of Keap1 (KEAP1 Cysteines) DM3HR7F MT DTT DM3HR7F MA Modulator DM3HR7F RN Recent progress in the development of small molecule Nrf2 modulators: a patent review (2012-2016).Expert Opin Ther Pat. 2017 Jul;27(7):763-785. DM3HR7F RU https://www.ncbi.nlm.nih.gov/pubmed/28454500 DM3HR7F DI DM3HR7F DM3HR7F DN PMID28454500-Compound-9 DM3HR7F MI TTA6ZN2 DM3HR7F MN Nuclear factor erythroid 2-related factor 2 (Nrf2) DM3HR7F MT DTT DM3HR7F MA Activator DM3HR7F RN Recent progress in the development of small molecule Nrf2 modulators: a patent review (2012-2016).Expert Opin Ther Pat. 2017 Jul;27(7):763-785. DM3HR7F RU https://www.ncbi.nlm.nih.gov/pubmed/28454500 DMJ1KFO DI DMJ1KFO DMJ1KFO DN PMID28454500-Compound-91 DMJ1KFO MI TTA6ZN2 DMJ1KFO MN Nuclear factor erythroid 2-related factor 2 (Nrf2) DMJ1KFO MT DTT DMJ1KFO MA Inhibitor DMJ1KFO RN Recent progress in the development of small molecule Nrf2 modulators: a patent review (2012-2016).Expert Opin Ther Pat. 2017 Jul;27(7):763-785. DMJ1KFO RU https://www.ncbi.nlm.nih.gov/pubmed/28454500 DM1RS4X DI DM1RS4X DM1RS4X DN PMID28454500-Compound-92 DM1RS4X MI TTA6ZN2 DM1RS4X MN Nuclear factor erythroid 2-related factor 2 (Nrf2) DM1RS4X MT DTT DM1RS4X MA Inhibitor DM1RS4X RN Recent progress in the development of small molecule Nrf2 modulators: a patent review (2012-2016).Expert Opin Ther Pat. 2017 Jul;27(7):763-785. DM1RS4X RU https://www.ncbi.nlm.nih.gov/pubmed/28454500 DMMDK6B DI DMMDK6B DMMDK6B DN PMID28454500-Compound-93 DMMDK6B MI TTA6ZN2 DMMDK6B MN Nuclear factor erythroid 2-related factor 2 (Nrf2) DMMDK6B MT DTT DMMDK6B MA Inhibitor DMMDK6B RN Recent progress in the development of small molecule Nrf2 modulators: a patent review (2012-2016).Expert Opin Ther Pat. 2017 Jul;27(7):763-785. DMMDK6B RU https://www.ncbi.nlm.nih.gov/pubmed/28454500 DM5Q962 DI DM5Q962 DM5Q962 DN PMID28454500-Compound-94 DM5Q962 MI TTA6ZN2 DM5Q962 MN Nuclear factor erythroid 2-related factor 2 (Nrf2) DM5Q962 MT DTT DM5Q962 MA Inhibitor DM5Q962 RN Recent progress in the development of small molecule Nrf2 modulators: a patent review (2012-2016).Expert Opin Ther Pat. 2017 Jul;27(7):763-785. DM5Q962 RU https://www.ncbi.nlm.nih.gov/pubmed/28454500 DM9L2VR DI DM9L2VR DM9L2VR DN PMID28454500-Compound-95 DM9L2VR MI TTA6ZN2 DM9L2VR MN Nuclear factor erythroid 2-related factor 2 (Nrf2) DM9L2VR MT DTT DM9L2VR MA Inhibitor DM9L2VR RN Recent progress in the development of small molecule Nrf2 modulators: a patent review (2012-2016).Expert Opin Ther Pat. 2017 Jul;27(7):763-785. DM9L2VR RU https://www.ncbi.nlm.nih.gov/pubmed/28454500 DM2A75P DI DM2A75P DM2A75P DN PMID28454500-Compound-96 DM2A75P MI TTA6ZN2 DM2A75P MN Nuclear factor erythroid 2-related factor 2 (Nrf2) DM2A75P MT DTT DM2A75P MA Inhibitor DM2A75P RN Recent progress in the development of small molecule Nrf2 modulators: a patent review (2012-2016).Expert Opin Ther Pat. 2017 Jul;27(7):763-785. DM2A75P RU https://www.ncbi.nlm.nih.gov/pubmed/28454500 DMHV75N DI DMHV75N DMHV75N DN PMID28460551-Compound-1 DMHV75N MI TT8FYO9 DMHV75N MN Platelet-derived growth factor receptor alpha (PDGFRA) DMHV75N MT DTT DMHV75N MA Inhibitor DMHV75N RN Cancer stem cell (CSC) inhibitors: a review of recent patents (2012-2015).Expert Opin Ther Pat. 2017 Jul;27(7):753-761. DMHV75N RU https://www.ncbi.nlm.nih.gov/pubmed/28460551 DM4DOUB DI DM4DOUB DM4DOUB DN PMID28460551-Compound-2 DM4DOUB MI TTI7421 DM4DOUB MN Platelet-derived growth factor receptor beta (PDGFRB) DM4DOUB MT DTT DM4DOUB MA Inhibitor DM4DOUB RN Cancer stem cell (CSC) inhibitors: a review of recent patents (2012-2015).Expert Opin Ther Pat. 2017 Jul;27(7):753-761. DM4DOUB RU https://www.ncbi.nlm.nih.gov/pubmed/28460551 DMA1FRM DI DMA1FRM DMA1FRM DN PMID28460551-Compound-3 DMA1FRM MI TTFJ8Q1 DMA1FRM MN Protein kinase C alpha (PRKCA) DMA1FRM MT DTT DMA1FRM MA Inhibitor DMA1FRM RN Cancer stem cell (CSC) inhibitors: a review of recent patents (2012-2015).Expert Opin Ther Pat. 2017 Jul;27(7):753-761. DMA1FRM RU https://www.ncbi.nlm.nih.gov/pubmed/28460551 DMT7U1O DI DMT7U1O DMT7U1O DN PMID28460551-Compound-6 DMT7U1O MI TT6PKBN DMT7U1O MN Proto-oncogene c-Src (SRC) DMT7U1O MT DTT DMT7U1O MA Inhibitor DMT7U1O RN Cancer stem cell (CSC) inhibitors: a review of recent patents (2012-2015).Expert Opin Ther Pat. 2017 Jul;27(7):753-761. DMT7U1O RU https://www.ncbi.nlm.nih.gov/pubmed/28460551 DMT7U1O DI DMT7U1O DMT7U1O DN PMID28460551-Compound-6 DMT7U1O MI TTWTSCV DMT7U1O MN RAC-alpha serine/threonine-protein kinase (AKT1) DMT7U1O MT DTT DMT7U1O MA Inhibitor DMT7U1O RN Cancer stem cell (CSC) inhibitors: a review of recent patents (2012-2015).Expert Opin Ther Pat. 2017 Jul;27(7):753-761. DMT7U1O RU https://www.ncbi.nlm.nih.gov/pubmed/28460551 DMLZV70 DI DMLZV70 DMLZV70 DN PMID28594589-Compound-TABLE3C1 DMLZV70 MI TTZCRP3 DMLZV70 MN ERK activator kinase (MEK) DMLZV70 MT DTT DMLZV70 MA Inhibitor DMLZV70 RN MEK inhibitors in oncology: a patent review (2015-Present).Expert Opin Ther Pat. 2017 Aug;27(8):887-906. DMLZV70 RU https://www.ncbi.nlm.nih.gov/pubmed/28594589 DMPK7IU DI DMPK7IU DMPK7IU DN PMID28594589-Compound-TABLE3C12 DMPK7IU MI TTZCRP3 DMPK7IU MN ERK activator kinase (MEK) DMPK7IU MT DTT DMPK7IU MA Inhibitor DMPK7IU RN MEK inhibitors in oncology: a patent review (2015-Present).Expert Opin Ther Pat. 2017 Aug;27(8):887-906. DMPK7IU RU https://www.ncbi.nlm.nih.gov/pubmed/28594589 DM4KWVF DI DM4KWVF DM4KWVF DN PMID28594589-Compound-TABLE3C14 DM4KWVF MI TTZCRP3 DM4KWVF MN ERK activator kinase (MEK) DM4KWVF MT DTT DM4KWVF MA Inhibitor DM4KWVF RN MEK inhibitors in oncology: a patent review (2015-Present).Expert Opin Ther Pat. 2017 Aug;27(8):887-906. DM4KWVF RU https://www.ncbi.nlm.nih.gov/pubmed/28594589 DMVYG0U DI DMVYG0U DMVYG0U DN PMID28594589-Compound-TABLE3C2 DMVYG0U MI TTZCRP3 DMVYG0U MN ERK activator kinase (MEK) DMVYG0U MT DTT DMVYG0U MA Inhibitor DMVYG0U RN MEK inhibitors in oncology: a patent review (2015-Present).Expert Opin Ther Pat. 2017 Aug;27(8):887-906. DMVYG0U RU https://www.ncbi.nlm.nih.gov/pubmed/28594589 DMBTZ8I DI DMBTZ8I DMBTZ8I DN PMID28621580-Compound-WO2013036866C66 DMBTZ8I MI TTOHSBA DMBTZ8I MN Vascular endothelial growth factor A (VEGFA) DMBTZ8I MT DTT DMBTZ8I MA Inhibitor DMBTZ8I RN VEGFR-2 inhibitors and the therapeutic applications thereof: a patent review (2012-2016).Expert Opin Ther Pat. 2017 Sep;27(9):987-1004. DMBTZ8I RU https://www.ncbi.nlm.nih.gov/pubmed/28621580 DM15OKA DI DM15OKA DM15OKA DN PMID28621580-Compound-WO2013112959C68 DM15OKA MI TTOHSBA DM15OKA MN Vascular endothelial growth factor A (VEGFA) DM15OKA MT DTT DM15OKA MA Inhibitor DM15OKA RN VEGFR-2 inhibitors and the therapeutic applications thereof: a patent review (2012-2016).Expert Opin Ther Pat. 2017 Sep;27(9):987-1004. DM15OKA RU https://www.ncbi.nlm.nih.gov/pubmed/28621580 DMR58TX DI DMR58TX DMR58TX DN PMID28621580-Compound-WO2014079545C69 DMR58TX MI TTOHSBA DMR58TX MN Vascular endothelial growth factor A (VEGFA) DMR58TX MT DTT DMR58TX MA Inhibitor DMR58TX RN VEGFR-2 inhibitors and the therapeutic applications thereof: a patent review (2012-2016).Expert Opin Ther Pat. 2017 Sep;27(9):987-1004. DMR58TX RU https://www.ncbi.nlm.nih.gov/pubmed/28621580 DMX96FI DI DMX96FI DMX96FI DN PMID28621580-Compound-WO2015089220C70 DMX96FI MI TTOHSBA DMX96FI MN Vascular endothelial growth factor A (VEGFA) DMX96FI MT DTT DMX96FI MA Inhibitor DMX96FI RN VEGFR-2 inhibitors and the therapeutic applications thereof: a patent review (2012-2016).Expert Opin Ther Pat. 2017 Sep;27(9):987-1004. DMX96FI RU https://www.ncbi.nlm.nih.gov/pubmed/28621580 DM36P7T DI DM36P7T DM36P7T DN PMID28627961-Compound-22 DM36P7T MI TTYLQ8V DM36P7T MN Prostaglandin E synthase (PTGES) DM36P7T MT DTT DM36P7T MA Inhibitor DM36P7T RN Microsomal prostaglandin E2 synthase-1 inhibitors: a patent review.Expert Opin Ther Pat. 2017 Sep;27(9):1047-1059. DM36P7T RU https://www.ncbi.nlm.nih.gov/pubmed/28627961 DMRLU8I DI DMRLU8I DMRLU8I DN PMID28627961-Compound-30 DMRLU8I MI TTYLQ8V DMRLU8I MN Prostaglandin E synthase (PTGES) DMRLU8I MT DTT DMRLU8I MA Inhibitor DMRLU8I RN Microsomal prostaglandin E2 synthase-1 inhibitors: a patent review.Expert Opin Ther Pat. 2017 Sep;27(9):1047-1059. DMRLU8I RU https://www.ncbi.nlm.nih.gov/pubmed/28627961 DMLGYXW DI DMLGYXW DMLGYXW DN PMID28627961-Compound-31 DMLGYXW MI TTYLQ8V DMLGYXW MN Prostaglandin E synthase (PTGES) DMLGYXW MT DTT DMLGYXW MA Inhibitor DMLGYXW RN Microsomal prostaglandin E2 synthase-1 inhibitors: a patent review.Expert Opin Ther Pat. 2017 Sep;27(9):1047-1059. DMLGYXW RU https://www.ncbi.nlm.nih.gov/pubmed/28627961 DM5IZKD DI DM5IZKD DM5IZKD DN PMID28627961-Compound-32 DM5IZKD MI TTYLQ8V DM5IZKD MN Prostaglandin E synthase (PTGES) DM5IZKD MT DTT DM5IZKD MA Inhibitor DM5IZKD RN Microsomal prostaglandin E2 synthase-1 inhibitors: a patent review.Expert Opin Ther Pat. 2017 Sep;27(9):1047-1059. DM5IZKD RU https://www.ncbi.nlm.nih.gov/pubmed/28627961 DMWV4YE DI DMWV4YE DMWV4YE DN PMID28627961-Compound-33 DMWV4YE MI TTYLQ8V DMWV4YE MN Prostaglandin E synthase (PTGES) DMWV4YE MT DTT DMWV4YE MA Inhibitor DMWV4YE RN Microsomal prostaglandin E2 synthase-1 inhibitors: a patent review.Expert Opin Ther Pat. 2017 Sep;27(9):1047-1059. DMWV4YE RU https://www.ncbi.nlm.nih.gov/pubmed/28627961 DMODL3P DI DMODL3P DMODL3P DN PMID28627961-Compound-41 DMODL3P MI TTYLQ8V DMODL3P MN Prostaglandin E synthase (PTGES) DMODL3P MT DTT DMODL3P MA Inhibitor DMODL3P RN Microsomal prostaglandin E2 synthase-1 inhibitors: a patent review.Expert Opin Ther Pat. 2017 Sep;27(9):1047-1059. DMODL3P RU https://www.ncbi.nlm.nih.gov/pubmed/28627961 DM7ATLP DI DM7ATLP DM7ATLP DN PMID28627961-Compound-44 DM7ATLP MI TTYLQ8V DM7ATLP MN Prostaglandin E synthase (PTGES) DM7ATLP MT DTT DM7ATLP MA Inhibitor DM7ATLP RN Microsomal prostaglandin E2 synthase-1 inhibitors: a patent review.Expert Opin Ther Pat. 2017 Sep;27(9):1047-1059. DM7ATLP RU https://www.ncbi.nlm.nih.gov/pubmed/28627961 DMBN3X4 DI DMBN3X4 DMBN3X4 DN PMID28766366-Compound-Scheme11 DMBN3X4 MI TTSBVFO DMBN3X4 MN Dual-specificity tyrosine-phosphorylation regulated kinase 1A (DYRK1A) DMBN3X4 MT DTT DMBN3X4 MA Inhibitor DMBN3X4 RN Dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A) inhibitors: a survey of recent patent literature.Expert Opin Ther Pat. 2017 Nov;27(11):1183-1199. DMBN3X4 RU https://www.ncbi.nlm.nih.gov/pubmed/28766366 DMMJ5SN DI DMMJ5SN DMMJ5SN DN PMID28766366-Compound-Scheme12-1 DMMJ5SN MI TTSBVFO DMMJ5SN MN Dual-specificity tyrosine-phosphorylation regulated kinase 1A (DYRK1A) DMMJ5SN MT DTT DMMJ5SN MA Inhibitor DMMJ5SN RN Dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A) inhibitors: a survey of recent patent literature.Expert Opin Ther Pat. 2017 Nov;27(11):1183-1199. DMMJ5SN RU https://www.ncbi.nlm.nih.gov/pubmed/28766366 DM3BA1L DI DM3BA1L DM3BA1L DN PMID28766366-Compound-Scheme12-2 DM3BA1L MI TTSBVFO DM3BA1L MN Dual-specificity tyrosine-phosphorylation regulated kinase 1A (DYRK1A) DM3BA1L MT DTT DM3BA1L MA Inhibitor DM3BA1L RN Dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A) inhibitors: a survey of recent patent literature.Expert Opin Ther Pat. 2017 Nov;27(11):1183-1199. DM3BA1L RU https://www.ncbi.nlm.nih.gov/pubmed/28766366 DM4V3AY DI DM4V3AY DM4V3AY DN PMID28766366-Compound-Scheme12-3 DM4V3AY MI TTSBVFO DM4V3AY MN Dual-specificity tyrosine-phosphorylation regulated kinase 1A (DYRK1A) DM4V3AY MT DTT DM4V3AY MA Inhibitor DM4V3AY RN Dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A) inhibitors: a survey of recent patent literature.Expert Opin Ther Pat. 2017 Nov;27(11):1183-1199. DM4V3AY RU https://www.ncbi.nlm.nih.gov/pubmed/28766366 DM5BG6L DI DM5BG6L DM5BG6L DN PMID28766366-Compound-Scheme12-4 DM5BG6L MI TTSBVFO DM5BG6L MN Dual-specificity tyrosine-phosphorylation regulated kinase 1A (DYRK1A) DM5BG6L MT DTT DM5BG6L MA Inhibitor DM5BG6L RN Dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A) inhibitors: a survey of recent patent literature.Expert Opin Ther Pat. 2017 Nov;27(11):1183-1199. DM5BG6L RU https://www.ncbi.nlm.nih.gov/pubmed/28766366 DMLQCYV DI DMLQCYV DMLQCYV DN PMID28766366-Compound-Scheme13INDY DMLQCYV MI TTSBVFO DMLQCYV MN Dual-specificity tyrosine-phosphorylation regulated kinase 1A (DYRK1A) DMLQCYV MT DTT DMLQCYV MA Inhibitor DMLQCYV RN Dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A) inhibitors: a survey of recent patent literature.Expert Opin Ther Pat. 2017 Nov;27(11):1183-1199. DMLQCYV RU https://www.ncbi.nlm.nih.gov/pubmed/28766366 DMBQ0RN DI DMBQ0RN DMBQ0RN DN PMID28766366-Compound-Scheme14BINDY DMBQ0RN MI TTSBVFO DMBQ0RN MN Dual-specificity tyrosine-phosphorylation regulated kinase 1A (DYRK1A) DMBQ0RN MT DTT DMBQ0RN MA Inhibitor DMBQ0RN RN Dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A) inhibitors: a survey of recent patent literature.Expert Opin Ther Pat. 2017 Nov;27(11):1183-1199. DMBQ0RN RU https://www.ncbi.nlm.nih.gov/pubmed/28766366 DMBQ0RN DI DMBQ0RN DMBQ0RN DN PMID28766366-Compound-Scheme14BINDY DMBQ0RN MI TTYGQ8A DMBQ0RN MN Dual-specificity tyrosine-phosphorylation regulated kinase 1B (DYRK1B) DMBQ0RN MT DTT DMBQ0RN MA Inhibitor DMBQ0RN RN Dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A) inhibitors: a survey of recent patent literature.Expert Opin Ther Pat. 2017 Nov;27(11):1183-1199. DMBQ0RN RU https://www.ncbi.nlm.nih.gov/pubmed/28766366 DMBQ0RN DI DMBQ0RN DMBQ0RN DN PMID28766366-Compound-Scheme14BINDY DMBQ0RN MI TT84OS6 DMBQ0RN MN Dual-specificity tyrosine-phosphorylation regulated kinase 2 (DYRK2) DMBQ0RN MT DTT DMBQ0RN MA Inhibitor DMBQ0RN RN Dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A) inhibitors: a survey of recent patent literature.Expert Opin Ther Pat. 2017 Nov;27(11):1183-1199. DMBQ0RN RU https://www.ncbi.nlm.nih.gov/pubmed/28766366 DMVG275 DI DMVG275 DMVG275 DN PMID28766366-Compound-Scheme15-1 DMVG275 MI TTSBVFO DMVG275 MN Dual-specificity tyrosine-phosphorylation regulated kinase 1A (DYRK1A) DMVG275 MT DTT DMVG275 MA Inhibitor DMVG275 RN Dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A) inhibitors: a survey of recent patent literature.Expert Opin Ther Pat. 2017 Nov;27(11):1183-1199. DMVG275 RU https://www.ncbi.nlm.nih.gov/pubmed/28766366 DMU8ENF DI DMU8ENF DMU8ENF DN PMID28766366-Compound-Scheme15-2 DMU8ENF MI TTSBVFO DMU8ENF MN Dual-specificity tyrosine-phosphorylation regulated kinase 1A (DYRK1A) DMU8ENF MT DTT DMU8ENF MA Inhibitor DMU8ENF RN Dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A) inhibitors: a survey of recent patent literature.Expert Opin Ther Pat. 2017 Nov;27(11):1183-1199. DMU8ENF RU https://www.ncbi.nlm.nih.gov/pubmed/28766366 DMA423P DI DMA423P DMA423P DN PMID28766366-Compound-Scheme15-3 DMA423P MI TTSBVFO DMA423P MN Dual-specificity tyrosine-phosphorylation regulated kinase 1A (DYRK1A) DMA423P MT DTT DMA423P MA Inhibitor DMA423P RN Dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A) inhibitors: a survey of recent patent literature.Expert Opin Ther Pat. 2017 Nov;27(11):1183-1199. DMA423P RU https://www.ncbi.nlm.nih.gov/pubmed/28766366 DMQ5UEA DI DMQ5UEA DMQ5UEA DN PMID28766366-Compound-Scheme16DMAT DMQ5UEA MI TTSBVFO DMQ5UEA MN Dual-specificity tyrosine-phosphorylation regulated kinase 1A (DYRK1A) DMQ5UEA MT DTT DMQ5UEA MA Inhibitor DMQ5UEA RN Dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A) inhibitors: a survey of recent patent literature.Expert Opin Ther Pat. 2017 Nov;27(11):1183-1199. DMQ5UEA RU https://www.ncbi.nlm.nih.gov/pubmed/28766366 DMQ5UEA DI DMQ5UEA DMQ5UEA DN PMID28766366-Compound-Scheme16DMAT DMQ5UEA MI TT84OS6 DMQ5UEA MN Dual-specificity tyrosine-phosphorylation regulated kinase 2 (DYRK2) DMQ5UEA MT DTT DMQ5UEA MA Inhibitor DMQ5UEA RN Dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A) inhibitors: a survey of recent patent literature.Expert Opin Ther Pat. 2017 Nov;27(11):1183-1199. DMQ5UEA RU https://www.ncbi.nlm.nih.gov/pubmed/28766366 DMBQ21J DI DMBQ21J DMBQ21J DN PMID28766366-Compound-Scheme18 DMBQ21J MI TTSBVFO DMBQ21J MN Dual-specificity tyrosine-phosphorylation regulated kinase 1A (DYRK1A) DMBQ21J MT DTT DMBQ21J MA Inhibitor DMBQ21J RN Dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A) inhibitors: a survey of recent patent literature.Expert Opin Ther Pat. 2017 Nov;27(11):1183-1199. DMBQ21J RU https://www.ncbi.nlm.nih.gov/pubmed/28766366 DMHIUWX DI DMHIUWX DMHIUWX DN PMID28766366-Compound-Scheme1WO2011135259 DMHIUWX MI TTSBVFO DMHIUWX MN Dual-specificity tyrosine-phosphorylation regulated kinase 1A (DYRK1A) DMHIUWX MT DTT DMHIUWX MA Inhibitor DMHIUWX RN Dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A) inhibitors: a survey of recent patent literature.Expert Opin Ther Pat. 2017 Nov;27(11):1183-1199. DMHIUWX RU https://www.ncbi.nlm.nih.gov/pubmed/28766366 DMWTRUK DI DMWTRUK DMWTRUK DN PMID28766366-Compound-Scheme21Left DMWTRUK MI TTSBVFO DMWTRUK MN Dual-specificity tyrosine-phosphorylation regulated kinase 1A (DYRK1A) DMWTRUK MT DTT DMWTRUK MA Inhibitor DMWTRUK RN Dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A) inhibitors: a survey of recent patent literature.Expert Opin Ther Pat. 2017 Nov;27(11):1183-1199. DMWTRUK RU https://www.ncbi.nlm.nih.gov/pubmed/28766366 DMWTRUK DI DMWTRUK DMWTRUK DN PMID28766366-Compound-Scheme21Left DMWTRUK MI TTYGQ8A DMWTRUK MN Dual-specificity tyrosine-phosphorylation regulated kinase 1B (DYRK1B) DMWTRUK MT DTT DMWTRUK MA Inhibitor DMWTRUK RN Dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A) inhibitors: a survey of recent patent literature.Expert Opin Ther Pat. 2017 Nov;27(11):1183-1199. DMWTRUK RU https://www.ncbi.nlm.nih.gov/pubmed/28766366 DMWTRUK DI DMWTRUK DMWTRUK DN PMID28766366-Compound-Scheme21Left DMWTRUK MI TT84OS6 DMWTRUK MN Dual-specificity tyrosine-phosphorylation regulated kinase 2 (DYRK2) DMWTRUK MT DTT DMWTRUK MA Inhibitor DMWTRUK RN Dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A) inhibitors: a survey of recent patent literature.Expert Opin Ther Pat. 2017 Nov;27(11):1183-1199. DMWTRUK RU https://www.ncbi.nlm.nih.gov/pubmed/28766366 DMWTRUK DI DMWTRUK DMWTRUK DN PMID28766366-Compound-Scheme21Left DMWTRUK MI TTV4EX0 DMWTRUK MN Dual-specificity tyrosine-phosphorylation regulated kinase 3 (DYRK3) DMWTRUK MT DTT DMWTRUK MA Inhibitor DMWTRUK RN Dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A) inhibitors: a survey of recent patent literature.Expert Opin Ther Pat. 2017 Nov;27(11):1183-1199. DMWTRUK RU https://www.ncbi.nlm.nih.gov/pubmed/28766366 DMF3X40 DI DMF3X40 DMF3X40 DN PMID28766366-Compound-Scheme21Right DMF3X40 MI TTSBVFO DMF3X40 MN Dual-specificity tyrosine-phosphorylation regulated kinase 1A (DYRK1A) DMF3X40 MT DTT DMF3X40 MA Inhibitor DMF3X40 RN Dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A) inhibitors: a survey of recent patent literature.Expert Opin Ther Pat. 2017 Nov;27(11):1183-1199. DMF3X40 RU https://www.ncbi.nlm.nih.gov/pubmed/28766366 DMF3X40 DI DMF3X40 DMF3X40 DN PMID28766366-Compound-Scheme21Right DMF3X40 MI TTYGQ8A DMF3X40 MN Dual-specificity tyrosine-phosphorylation regulated kinase 1B (DYRK1B) DMF3X40 MT DTT DMF3X40 MA Inhibitor DMF3X40 RN Dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A) inhibitors: a survey of recent patent literature.Expert Opin Ther Pat. 2017 Nov;27(11):1183-1199. DMF3X40 RU https://www.ncbi.nlm.nih.gov/pubmed/28766366 DMF3X40 DI DMF3X40 DMF3X40 DN PMID28766366-Compound-Scheme21Right DMF3X40 MI TT84OS6 DMF3X40 MN Dual-specificity tyrosine-phosphorylation regulated kinase 2 (DYRK2) DMF3X40 MT DTT DMF3X40 MA Inhibitor DMF3X40 RN Dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A) inhibitors: a survey of recent patent literature.Expert Opin Ther Pat. 2017 Nov;27(11):1183-1199. DMF3X40 RU https://www.ncbi.nlm.nih.gov/pubmed/28766366 DMF3X40 DI DMF3X40 DMF3X40 DN PMID28766366-Compound-Scheme21Right DMF3X40 MI TTV4EX0 DMF3X40 MN Dual-specificity tyrosine-phosphorylation regulated kinase 3 (DYRK3) DMF3X40 MT DTT DMF3X40 MA Inhibitor DMF3X40 RN Dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A) inhibitors: a survey of recent patent literature.Expert Opin Ther Pat. 2017 Nov;27(11):1183-1199. DMF3X40 RU https://www.ncbi.nlm.nih.gov/pubmed/28766366 DMD8N5O DI DMD8N5O DMD8N5O DN PMID28766366-Compound-Scheme22Middle DMD8N5O MI TTXZCO0 DMD8N5O MN Microtubule-associated protein tau phosphorylation (MAPT p) DMD8N5O MT DTT DMD8N5O MA Inhibitor DMD8N5O RN Dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A) inhibitors: a survey of recent patent literature.Expert Opin Ther Pat. 2017 Nov;27(11):1183-1199. DMD8N5O RU https://www.ncbi.nlm.nih.gov/pubmed/28766366 DMRLSKV DI DMRLSKV DMRLSKV DN PMID28766366-Compound-Scheme23MPPDerivatives DMRLSKV MI TTSBVFO DMRLSKV MN Dual-specificity tyrosine-phosphorylation regulated kinase 1A (DYRK1A) DMRLSKV MT DTT DMRLSKV MA Inhibitor DMRLSKV RN Dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A) inhibitors: a survey of recent patent literature.Expert Opin Ther Pat. 2017 Nov;27(11):1183-1199. DMRLSKV RU https://www.ncbi.nlm.nih.gov/pubmed/28766366 DMBWAV7 DI DMBWAV7 DMBWAV7 DN PMID28766366-Compound-Scheme24-11H-pyrido[4,3-a]carbazole DMBWAV7 MI TTSBVFO DMBWAV7 MN Dual-specificity tyrosine-phosphorylation regulated kinase 1A (DYRK1A) DMBWAV7 MT DTT DMBWAV7 MA Inhibitor DMBWAV7 RN Dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A) inhibitors: a survey of recent patent literature.Expert Opin Ther Pat. 2017 Nov;27(11):1183-1199. DMBWAV7 RU https://www.ncbi.nlm.nih.gov/pubmed/28766366 DMNKRSZ DI DMNKRSZ DMNKRSZ DN PMID28766366-Compound-Scheme24Paprotrain DMNKRSZ MI TTSBVFO DMNKRSZ MN Dual-specificity tyrosine-phosphorylation regulated kinase 1A (DYRK1A) DMNKRSZ MT DTT DMNKRSZ MA Inhibitor DMNKRSZ RN Dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A) inhibitors: a survey of recent patent literature.Expert Opin Ther Pat. 2017 Nov;27(11):1183-1199. DMNKRSZ RU https://www.ncbi.nlm.nih.gov/pubmed/28766366 DM7OGWH DI DM7OGWH DM7OGWH DN PMID28766366-Compound-Scheme25-2 DM7OGWH MI TTSBVFO DM7OGWH MN Dual-specificity tyrosine-phosphorylation regulated kinase 1A (DYRK1A) DM7OGWH MT DTT DM7OGWH MA Inhibitor DM7OGWH RN Dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A) inhibitors: a survey of recent patent literature.Expert Opin Ther Pat. 2017 Nov;27(11):1183-1199. DM7OGWH RU https://www.ncbi.nlm.nih.gov/pubmed/28766366 DM7OGWH DI DM7OGWH DM7OGWH DN PMID28766366-Compound-Scheme25-2 DM7OGWH MI TTYGQ8A DM7OGWH MN Dual-specificity tyrosine-phosphorylation regulated kinase 1B (DYRK1B) DM7OGWH MT DTT DM7OGWH MA Inhibitor DM7OGWH RN Dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A) inhibitors: a survey of recent patent literature.Expert Opin Ther Pat. 2017 Nov;27(11):1183-1199. DM7OGWH RU https://www.ncbi.nlm.nih.gov/pubmed/28766366 DMGVT5Y DI DMGVT5Y DMGVT5Y DN PMID28766366-Compound-Scheme25-3 DMGVT5Y MI TTSBVFO DMGVT5Y MN Dual-specificity tyrosine-phosphorylation regulated kinase 1A (DYRK1A) DMGVT5Y MT DTT DMGVT5Y MA Inhibitor DMGVT5Y RN Dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A) inhibitors: a survey of recent patent literature.Expert Opin Ther Pat. 2017 Nov;27(11):1183-1199. DMGVT5Y RU https://www.ncbi.nlm.nih.gov/pubmed/28766366 DMGVT5Y DI DMGVT5Y DMGVT5Y DN PMID28766366-Compound-Scheme25-3 DMGVT5Y MI TTYGQ8A DMGVT5Y MN Dual-specificity tyrosine-phosphorylation regulated kinase 1B (DYRK1B) DMGVT5Y MT DTT DMGVT5Y MA Inhibitor DMGVT5Y RN Dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A) inhibitors: a survey of recent patent literature.Expert Opin Ther Pat. 2017 Nov;27(11):1183-1199. DMGVT5Y RU https://www.ncbi.nlm.nih.gov/pubmed/28766366 DMOD9BY DI DMOD9BY DMOD9BY DN PMID28766366-Compound-Scheme25-4 DMOD9BY MI TTSBVFO DMOD9BY MN Dual-specificity tyrosine-phosphorylation regulated kinase 1A (DYRK1A) DMOD9BY MT DTT DMOD9BY MA Inhibitor DMOD9BY RN Dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A) inhibitors: a survey of recent patent literature.Expert Opin Ther Pat. 2017 Nov;27(11):1183-1199. DMOD9BY RU https://www.ncbi.nlm.nih.gov/pubmed/28766366 DMOD9BY DI DMOD9BY DMOD9BY DN PMID28766366-Compound-Scheme25-4 DMOD9BY MI TTYGQ8A DMOD9BY MN Dual-specificity tyrosine-phosphorylation regulated kinase 1B (DYRK1B) DMOD9BY MT DTT DMOD9BY MA Inhibitor DMOD9BY RN Dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A) inhibitors: a survey of recent patent literature.Expert Opin Ther Pat. 2017 Nov;27(11):1183-1199. DMOD9BY RU https://www.ncbi.nlm.nih.gov/pubmed/28766366 DM3Q1FT DI DM3Q1FT DM3Q1FT DN PMID28766366-Compound-Scheme27LeucettamineB DM3Q1FT MI TTSBVFO DM3Q1FT MN Dual-specificity tyrosine-phosphorylation regulated kinase 1A (DYRK1A) DM3Q1FT MT DTT DM3Q1FT MA Inhibitor DM3Q1FT RN Dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A) inhibitors: a survey of recent patent literature.Expert Opin Ther Pat. 2017 Nov;27(11):1183-1199. DM3Q1FT RU https://www.ncbi.nlm.nih.gov/pubmed/28766366 DMLX26R DI DMLX26R DMLX26R DN PMID28766366-Compound-Scheme27LeucettineL41 DMLX26R MI TTSBVFO DMLX26R MN Dual-specificity tyrosine-phosphorylation regulated kinase 1A (DYRK1A) DMLX26R MT DTT DMLX26R MA Inhibitor DMLX26R RN Dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A) inhibitors: a survey of recent patent literature.Expert Opin Ther Pat. 2017 Nov;27(11):1183-1199. DMLX26R RU https://www.ncbi.nlm.nih.gov/pubmed/28766366 DMPVZ6W DI DMPVZ6W DMPVZ6W DN PMID28766366-Compound-Scheme27LeucettineL41derivatives DMPVZ6W MI TTSBVFO DMPVZ6W MN Dual-specificity tyrosine-phosphorylation regulated kinase 1A (DYRK1A) DMPVZ6W MT DTT DMPVZ6W MA Inhibitor DMPVZ6W RN Dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A) inhibitors: a survey of recent patent literature.Expert Opin Ther Pat. 2017 Nov;27(11):1183-1199. DMPVZ6W RU https://www.ncbi.nlm.nih.gov/pubmed/28766366 DMO4Q95 DI DMO4Q95 DMO4Q95 DN PMID28766366-Compound-Scheme2WO2012/098065bottom DMO4Q95 MI TTSBVFO DMO4Q95 MN Dual-specificity tyrosine-phosphorylation regulated kinase 1A (DYRK1A) DMO4Q95 MT DTT DMO4Q95 MA Inhibitor DMO4Q95 RN Dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A) inhibitors: a survey of recent patent literature.Expert Opin Ther Pat. 2017 Nov;27(11):1183-1199. DMO4Q95 RU https://www.ncbi.nlm.nih.gov/pubmed/28766366 DMO4Q95 DI DMO4Q95 DMO4Q95 DN PMID28766366-Compound-Scheme2WO2012/098065bottom DMO4Q95 MI TTYGQ8A DMO4Q95 MN Dual-specificity tyrosine-phosphorylation regulated kinase 1B (DYRK1B) DMO4Q95 MT DTT DMO4Q95 MA Inhibitor DMO4Q95 RN Dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A) inhibitors: a survey of recent patent literature.Expert Opin Ther Pat. 2017 Nov;27(11):1183-1199. DMO4Q95 RU https://www.ncbi.nlm.nih.gov/pubmed/28766366 DMVJDRI DI DMVJDRI DMVJDRI DN PMID28766366-Compound-Scheme2WO2012/098065upper DMVJDRI MI TTSBVFO DMVJDRI MN Dual-specificity tyrosine-phosphorylation regulated kinase 1A (DYRK1A) DMVJDRI MT DTT DMVJDRI MA Inhibitor DMVJDRI RN Dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A) inhibitors: a survey of recent patent literature.Expert Opin Ther Pat. 2017 Nov;27(11):1183-1199. DMVJDRI RU https://www.ncbi.nlm.nih.gov/pubmed/28766366 DMVJDRI DI DMVJDRI DMVJDRI DN PMID28766366-Compound-Scheme2WO2012/098065upper DMVJDRI MI TTYGQ8A DMVJDRI MN Dual-specificity tyrosine-phosphorylation regulated kinase 1B (DYRK1B) DMVJDRI MT DTT DMVJDRI MA Inhibitor DMVJDRI RN Dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A) inhibitors: a survey of recent patent literature.Expert Opin Ther Pat. 2017 Nov;27(11):1183-1199. DMVJDRI RU https://www.ncbi.nlm.nih.gov/pubmed/28766366 DMDXIU9 DI DMDXIU9 DMDXIU9 DN PMID28766366-Compound-Scheme4Bottom DMDXIU9 MI TTSBVFO DMDXIU9 MN Dual-specificity tyrosine-phosphorylation regulated kinase 1A (DYRK1A) DMDXIU9 MT DTT DMDXIU9 MA Inhibitor DMDXIU9 RN Dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A) inhibitors: a survey of recent patent literature.Expert Opin Ther Pat. 2017 Nov;27(11):1183-1199. DMDXIU9 RU https://www.ncbi.nlm.nih.gov/pubmed/28766366 DMDXIU9 DI DMDXIU9 DMDXIU9 DN PMID28766366-Compound-Scheme4Bottom DMDXIU9 MI TTYGQ8A DMDXIU9 MN Dual-specificity tyrosine-phosphorylation regulated kinase 1B (DYRK1B) DMDXIU9 MT DTT DMDXIU9 MA Inhibitor DMDXIU9 RN Dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A) inhibitors: a survey of recent patent literature.Expert Opin Ther Pat. 2017 Nov;27(11):1183-1199. DMDXIU9 RU https://www.ncbi.nlm.nih.gov/pubmed/28766366 DMPH4JV DI DMPH4JV DMPH4JV DN PMID28766366-Compound-Scheme4Upper DMPH4JV MI TTSBVFO DMPH4JV MN Dual-specificity tyrosine-phosphorylation regulated kinase 1A (DYRK1A) DMPH4JV MT DTT DMPH4JV MA Inhibitor DMPH4JV RN Dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A) inhibitors: a survey of recent patent literature.Expert Opin Ther Pat. 2017 Nov;27(11):1183-1199. DMPH4JV RU https://www.ncbi.nlm.nih.gov/pubmed/28766366 DMPH4JV DI DMPH4JV DMPH4JV DN PMID28766366-Compound-Scheme4Upper DMPH4JV MI TTYGQ8A DMPH4JV MN Dual-specificity tyrosine-phosphorylation regulated kinase 1B (DYRK1B) DMPH4JV MT DTT DMPH4JV MA Inhibitor DMPH4JV RN Dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A) inhibitors: a survey of recent patent literature.Expert Opin Ther Pat. 2017 Nov;27(11):1183-1199. DMPH4JV RU https://www.ncbi.nlm.nih.gov/pubmed/28766366 DMO6KZ5 DI DMO6KZ5 DMO6KZ5 DN PMID28766366-Compound-Scheme5 DMO6KZ5 MI TTSBVFO DMO6KZ5 MN Dual-specificity tyrosine-phosphorylation regulated kinase 1A (DYRK1A) DMO6KZ5 MT DTT DMO6KZ5 MA Inhibitor DMO6KZ5 RN Dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A) inhibitors: a survey of recent patent literature.Expert Opin Ther Pat. 2017 Nov;27(11):1183-1199. DMO6KZ5 RU https://www.ncbi.nlm.nih.gov/pubmed/28766366 DMO6KZ5 DI DMO6KZ5 DMO6KZ5 DN PMID28766366-Compound-Scheme5 DMO6KZ5 MI TTYGQ8A DMO6KZ5 MN Dual-specificity tyrosine-phosphorylation regulated kinase 1B (DYRK1B) DMO6KZ5 MT DTT DMO6KZ5 MA Inhibitor DMO6KZ5 RN Dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A) inhibitors: a survey of recent patent literature.Expert Opin Ther Pat. 2017 Nov;27(11):1183-1199. DMO6KZ5 RU https://www.ncbi.nlm.nih.gov/pubmed/28766366 DMJOG3W DI DMJOG3W DMJOG3W DN PMID28766366-Compound-Scheme6Pyrrolo[2,3-d]pyrimidines DMJOG3W MI TTSBVFO DMJOG3W MN Dual-specificity tyrosine-phosphorylation regulated kinase 1A (DYRK1A) DMJOG3W MT DTT DMJOG3W MA Inhibitor DMJOG3W RN Dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A) inhibitors: a survey of recent patent literature.Expert Opin Ther Pat. 2017 Nov;27(11):1183-1199. DMJOG3W RU https://www.ncbi.nlm.nih.gov/pubmed/28766366 DMQV6R0 DI DMQV6R0 DMQV6R0 DN PMID28766366-Compound-Scheme7WO2012/098070bottom DMQV6R0 MI TTSBVFO DMQV6R0 MN Dual-specificity tyrosine-phosphorylation regulated kinase 1A (DYRK1A) DMQV6R0 MT DTT DMQV6R0 MA Inhibitor DMQV6R0 RN Dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A) inhibitors: a survey of recent patent literature.Expert Opin Ther Pat. 2017 Nov;27(11):1183-1199. DMQV6R0 RU https://www.ncbi.nlm.nih.gov/pubmed/28766366 DMQV6R0 DI DMQV6R0 DMQV6R0 DN PMID28766366-Compound-Scheme7WO2012/098070bottom DMQV6R0 MI TTYGQ8A DMQV6R0 MN Dual-specificity tyrosine-phosphorylation regulated kinase 1B (DYRK1B) DMQV6R0 MT DTT DMQV6R0 MA Inhibitor DMQV6R0 RN Dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A) inhibitors: a survey of recent patent literature.Expert Opin Ther Pat. 2017 Nov;27(11):1183-1199. DMQV6R0 RU https://www.ncbi.nlm.nih.gov/pubmed/28766366 DMGAQR5 DI DMGAQR5 DMGAQR5 DN PMID28766366-Compound-Scheme7WO2012/098070upper DMGAQR5 MI TTSBVFO DMGAQR5 MN Dual-specificity tyrosine-phosphorylation regulated kinase 1A (DYRK1A) DMGAQR5 MT DTT DMGAQR5 MA Inhibitor DMGAQR5 RN Dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A) inhibitors: a survey of recent patent literature.Expert Opin Ther Pat. 2017 Nov;27(11):1183-1199. DMGAQR5 RU https://www.ncbi.nlm.nih.gov/pubmed/28766366 DMGAQR5 DI DMGAQR5 DMGAQR5 DN PMID28766366-Compound-Scheme7WO2012/098070upper DMGAQR5 MI TTYGQ8A DMGAQR5 MN Dual-specificity tyrosine-phosphorylation regulated kinase 1B (DYRK1B) DMGAQR5 MT DTT DMGAQR5 MA Inhibitor DMGAQR5 RN Dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A) inhibitors: a survey of recent patent literature.Expert Opin Ther Pat. 2017 Nov;27(11):1183-1199. DMGAQR5 RU https://www.ncbi.nlm.nih.gov/pubmed/28766366 DMSX09A DI DMSX09A DMSX09A DN PMID28766366-Compound-Scheme8NCGC-00010037 DMSX09A MI TTSBVFO DMSX09A MN Dual-specificity tyrosine-phosphorylation regulated kinase 1A (DYRK1A) DMSX09A MT DTT DMSX09A MA Inhibitor DMSX09A RN Dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A) inhibitors: a survey of recent patent literature.Expert Opin Ther Pat. 2017 Nov;27(11):1183-1199. DMSX09A RU https://www.ncbi.nlm.nih.gov/pubmed/28766366 DMDUSN5 DI DMDUSN5 DMDUSN5 DN PMID28766366-Compound-Scheme8NCGC-00185981 DMDUSN5 MI TTSBVFO DMDUSN5 MN Dual-specificity tyrosine-phosphorylation regulated kinase 1A (DYRK1A) DMDUSN5 MT DTT DMDUSN5 MA Inhibitor DMDUSN5 RN Dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A) inhibitors: a survey of recent patent literature.Expert Opin Ther Pat. 2017 Nov;27(11):1183-1199. DMDUSN5 RU https://www.ncbi.nlm.nih.gov/pubmed/28766366 DMUWZD9 DI DMUWZD9 DMUWZD9 DN PMID28766366-Compound-Scheme8NCGC-00189310 DMUWZD9 MI TTSBVFO DMUWZD9 MN Dual-specificity tyrosine-phosphorylation regulated kinase 1A (DYRK1A) DMUWZD9 MT DTT DMUWZD9 MA Inhibitor DMUWZD9 RN Dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A) inhibitors: a survey of recent patent literature.Expert Opin Ther Pat. 2017 Nov;27(11):1183-1199. DMUWZD9 RU https://www.ncbi.nlm.nih.gov/pubmed/28766366 DMMZGC8 DI DMMZGC8 DMMZGC8 DN PMID28766366-Compound-Scheme9EHT1610 DMMZGC8 MI TTSBVFO DMMZGC8 MN Dual-specificity tyrosine-phosphorylation regulated kinase 1A (DYRK1A) DMMZGC8 MT DTT DMMZGC8 MA Inhibitor DMMZGC8 RN Dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A) inhibitors: a survey of recent patent literature.Expert Opin Ther Pat. 2017 Nov;27(11):1183-1199. DMMZGC8 RU https://www.ncbi.nlm.nih.gov/pubmed/28766366 DMMZGC8 DI DMMZGC8 DMMZGC8 DN PMID28766366-Compound-Scheme9EHT1610 DMMZGC8 MI TTYGQ8A DMMZGC8 MN Dual-specificity tyrosine-phosphorylation regulated kinase 1B (DYRK1B) DMMZGC8 MT DTT DMMZGC8 MA Inhibitor DMMZGC8 RN Dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A) inhibitors: a survey of recent patent literature.Expert Opin Ther Pat. 2017 Nov;27(11):1183-1199. DMMZGC8 RU https://www.ncbi.nlm.nih.gov/pubmed/28766366 DMVBPML DI DMVBPML DMVBPML DN PMID28766366-Compound-Scheme9EHT3356 DMVBPML MI TTSBVFO DMVBPML MN Dual-specificity tyrosine-phosphorylation regulated kinase 1A (DYRK1A) DMVBPML MT DTT DMVBPML MA Inhibitor DMVBPML RN Dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A) inhibitors: a survey of recent patent literature.Expert Opin Ther Pat. 2017 Nov;27(11):1183-1199. DMVBPML RU https://www.ncbi.nlm.nih.gov/pubmed/28766366 DMVBPML DI DMVBPML DMVBPML DN PMID28766366-Compound-Scheme9EHT3356 DMVBPML MI TTYGQ8A DMVBPML MN Dual-specificity tyrosine-phosphorylation regulated kinase 1B (DYRK1B) DMVBPML MT DTT DMVBPML MA Inhibitor DMVBPML RN Dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A) inhibitors: a survey of recent patent literature.Expert Opin Ther Pat. 2017 Nov;27(11):1183-1199. DMVBPML RU https://www.ncbi.nlm.nih.gov/pubmed/28766366 DM0O18N DI DM0O18N DM0O18N DN PMID28766366-Compound-Scheme9EHT5372 DM0O18N MI TTSBVFO DM0O18N MN Dual-specificity tyrosine-phosphorylation regulated kinase 1A (DYRK1A) DM0O18N MT DTT DM0O18N MA Inhibitor DM0O18N RN Dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A) inhibitors: a survey of recent patent literature.Expert Opin Ther Pat. 2017 Nov;27(11):1183-1199. DM0O18N RU https://www.ncbi.nlm.nih.gov/pubmed/28766366 DM0O18N DI DM0O18N DM0O18N DN PMID28766366-Compound-Scheme9EHT5372 DM0O18N MI TTYGQ8A DM0O18N MN Dual-specificity tyrosine-phosphorylation regulated kinase 1B (DYRK1B) DM0O18N MT DTT DM0O18N MA Inhibitor DM0O18N RN Dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A) inhibitors: a survey of recent patent literature.Expert Opin Ther Pat. 2017 Nov;27(11):1183-1199. DM0O18N RU https://www.ncbi.nlm.nih.gov/pubmed/28766366 DMVY6PX DI DMVY6PX DMVY6PX DN PMID28766366-Compound-Scheme9EHT6840 DMVY6PX MI TTSBVFO DMVY6PX MN Dual-specificity tyrosine-phosphorylation regulated kinase 1A (DYRK1A) DMVY6PX MT DTT DMVY6PX MA Inhibitor DMVY6PX RN Dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A) inhibitors: a survey of recent patent literature.Expert Opin Ther Pat. 2017 Nov;27(11):1183-1199. DMVY6PX RU https://www.ncbi.nlm.nih.gov/pubmed/28766366 DMVY6PX DI DMVY6PX DMVY6PX DN PMID28766366-Compound-Scheme9EHT6840 DMVY6PX MI TTYGQ8A DMVY6PX MN Dual-specificity tyrosine-phosphorylation regulated kinase 1B (DYRK1B) DMVY6PX MT DTT DMVY6PX MA Inhibitor DMVY6PX RN Dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A) inhibitors: a survey of recent patent literature.Expert Opin Ther Pat. 2017 Nov;27(11):1183-1199. DMVY6PX RU https://www.ncbi.nlm.nih.gov/pubmed/28766366 DM7RPKM DI DM7RPKM DM7RPKM DN PMID28766366-Compound-Scheme9EHT9851 DM7RPKM MI TTSBVFO DM7RPKM MN Dual-specificity tyrosine-phosphorylation regulated kinase 1A (DYRK1A) DM7RPKM MT DTT DM7RPKM MA Inhibitor DM7RPKM RN Dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A) inhibitors: a survey of recent patent literature.Expert Opin Ther Pat. 2017 Nov;27(11):1183-1199. DM7RPKM RU https://www.ncbi.nlm.nih.gov/pubmed/28766366 DM7RPKM DI DM7RPKM DM7RPKM DN PMID28766366-Compound-Scheme9EHT9851 DM7RPKM MI TTYGQ8A DM7RPKM MN Dual-specificity tyrosine-phosphorylation regulated kinase 1B (DYRK1B) DM7RPKM MT DTT DM7RPKM MA Inhibitor DM7RPKM RN Dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A) inhibitors: a survey of recent patent literature.Expert Opin Ther Pat. 2017 Nov;27(11):1183-1199. DM7RPKM RU https://www.ncbi.nlm.nih.gov/pubmed/28766366 DMQJF15 DI DMQJF15 DMQJF15 DN PMID28870136-Compound-36 DMQJF15 MI TTK0O6Y DMQJF15 MN Ecto-5'-nucleotidase (CD73) DMQJF15 MT DTT DMQJF15 MA Inhibitor DMQJF15 RN Ectonucleotidase inhibitors: a patent review (2011-2016).Expert Opin Ther Pat. 2017 Dec;27(12):1291-1304. DMQJF15 RU https://www.ncbi.nlm.nih.gov/pubmed/28870136 DMAPMG2 DI DMAPMG2 DMAPMG2 DN PMID28870136-Compound-37 DMAPMG2 MI TTK0O6Y DMAPMG2 MN Ecto-5'-nucleotidase (CD73) DMAPMG2 MT DTT DMAPMG2 MA Inhibitor DMAPMG2 RN Ectonucleotidase inhibitors: a patent review (2011-2016).Expert Opin Ther Pat. 2017 Dec;27(12):1291-1304. DMAPMG2 RU https://www.ncbi.nlm.nih.gov/pubmed/28870136 DM67XSL DI DM67XSL DM67XSL DN PMID28870136-Compound-38 DM67XSL MI TTK0O6Y DM67XSL MN Ecto-5'-nucleotidase (CD73) DM67XSL MT DTT DM67XSL MA Inhibitor DM67XSL RN Ectonucleotidase inhibitors: a patent review (2011-2016).Expert Opin Ther Pat. 2017 Dec;27(12):1291-1304. DM67XSL RU https://www.ncbi.nlm.nih.gov/pubmed/28870136 DMU18W6 DI DMU18W6 DMU18W6 DN PMID28870136-Compound-39 DMU18W6 MI TTK0O6Y DMU18W6 MN Ecto-5'-nucleotidase (CD73) DMU18W6 MT DTT DMU18W6 MA Inhibitor DMU18W6 RN Ectonucleotidase inhibitors: a patent review (2011-2016).Expert Opin Ther Pat. 2017 Dec;27(12):1291-1304. DMU18W6 RU https://www.ncbi.nlm.nih.gov/pubmed/28870136 DMJP0AG DI DMJP0AG DMJP0AG DN PMID28870136-Compound-40 DMJP0AG MI TTK0O6Y DMJP0AG MN Ecto-5'-nucleotidase (CD73) DMJP0AG MT DTT DMJP0AG MA Inhibitor DMJP0AG RN Ectonucleotidase inhibitors: a patent review (2011-2016).Expert Opin Ther Pat. 2017 Dec;27(12):1291-1304. DMJP0AG RU https://www.ncbi.nlm.nih.gov/pubmed/28870136 DMSWM9Q DI DMSWM9Q DMSWM9Q DN PMID28870136-Compound-41 DMSWM9Q MI TTK0O6Y DMSWM9Q MN Ecto-5'-nucleotidase (CD73) DMSWM9Q MT DTT DMSWM9Q MA Inhibitor DMSWM9Q RN Ectonucleotidase inhibitors: a patent review (2011-2016).Expert Opin Ther Pat. 2017 Dec;27(12):1291-1304. DMSWM9Q RU https://www.ncbi.nlm.nih.gov/pubmed/28870136 DMV0R2X DI DMV0R2X DMV0R2X DN PMID28870136-Compound-42 DMV0R2X MI TTK0O6Y DMV0R2X MN Ecto-5'-nucleotidase (CD73) DMV0R2X MT DTT DMV0R2X MA Inhibitor DMV0R2X RN Ectonucleotidase inhibitors: a patent review (2011-2016).Expert Opin Ther Pat. 2017 Dec;27(12):1291-1304. DMV0R2X RU https://www.ncbi.nlm.nih.gov/pubmed/28870136 DMWGV8N DI DMWGV8N DMWGV8N DN PMID28870136-Compound-43 DMWGV8N MI TTK0O6Y DMWGV8N MN Ecto-5'-nucleotidase (CD73) DMWGV8N MT DTT DMWGV8N MA Inhibitor DMWGV8N RN Ectonucleotidase inhibitors: a patent review (2011-2016).Expert Opin Ther Pat. 2017 Dec;27(12):1291-1304. DMWGV8N RU https://www.ncbi.nlm.nih.gov/pubmed/28870136 DMNOAQB DI DMNOAQB DMNOAQB DN PMID28870136-Compound-44 DMNOAQB MI TTK0O6Y DMNOAQB MN Ecto-5'-nucleotidase (CD73) DMNOAQB MT DTT DMNOAQB MA Inhibitor DMNOAQB RN Ectonucleotidase inhibitors: a patent review (2011-2016).Expert Opin Ther Pat. 2017 Dec;27(12):1291-1304. DMNOAQB RU https://www.ncbi.nlm.nih.gov/pubmed/28870136 DM1QHV0 DI DM1QHV0 DM1QHV0 DN PMID28870136-Compound-45 DM1QHV0 MI TTK0O6Y DM1QHV0 MN Ecto-5'-nucleotidase (CD73) DM1QHV0 MT DTT DM1QHV0 MA Inhibitor DM1QHV0 RN Ectonucleotidase inhibitors: a patent review (2011-2016).Expert Opin Ther Pat. 2017 Dec;27(12):1291-1304. DM1QHV0 RU https://www.ncbi.nlm.nih.gov/pubmed/28870136 DM4FD7C DI DM4FD7C DM4FD7C DN PMID28870136-Compound-46 DM4FD7C MI TTK0O6Y DM4FD7C MN Ecto-5'-nucleotidase (CD73) DM4FD7C MT DTT DM4FD7C MA Inhibitor DM4FD7C RN Ectonucleotidase inhibitors: a patent review (2011-2016).Expert Opin Ther Pat. 2017 Dec;27(12):1291-1304. DM4FD7C RU https://www.ncbi.nlm.nih.gov/pubmed/28870136 DMYWBRX DI DMYWBRX DMYWBRX DN PMID28870136-Compound-47 DMYWBRX MI TTK0O6Y DMYWBRX MN Ecto-5'-nucleotidase (CD73) DMYWBRX MT DTT DMYWBRX MA Inhibitor DMYWBRX RN Ectonucleotidase inhibitors: a patent review (2011-2016).Expert Opin Ther Pat. 2017 Dec;27(12):1291-1304. DMYWBRX RU https://www.ncbi.nlm.nih.gov/pubmed/28870136 DMPIM9L DI DMPIM9L DMPIM9L DN PMID28870136-Compound-48 DMPIM9L MI TTK0O6Y DMPIM9L MN Ecto-5'-nucleotidase (CD73) DMPIM9L MT DTT DMPIM9L MA Inhibitor DMPIM9L RN Ectonucleotidase inhibitors: a patent review (2011-2016).Expert Opin Ther Pat. 2017 Dec;27(12):1291-1304. DMPIM9L RU https://www.ncbi.nlm.nih.gov/pubmed/28870136 DMTUC9E DI DMTUC9E DMTUC9E DN PMID28870136-Compound-49 DMTUC9E MI TTK0O6Y DMTUC9E MN Ecto-5'-nucleotidase (CD73) DMTUC9E MT DTT DMTUC9E MA Inhibitor DMTUC9E RN Ectonucleotidase inhibitors: a patent review (2011-2016).Expert Opin Ther Pat. 2017 Dec;27(12):1291-1304. DMTUC9E RU https://www.ncbi.nlm.nih.gov/pubmed/28870136 DM42OYU DI DM42OYU DM42OYU DN PMID28870136-Compound-50 DM42OYU MI TTK0O6Y DM42OYU MN Ecto-5'-nucleotidase (CD73) DM42OYU MT DTT DM42OYU MA Inhibitor DM42OYU RN Ectonucleotidase inhibitors: a patent review (2011-2016).Expert Opin Ther Pat. 2017 Dec;27(12):1291-1304. DM42OYU RU https://www.ncbi.nlm.nih.gov/pubmed/28870136 DMU3MQB DI DMU3MQB DMU3MQB DN PMID28870136-Compound-51 DMU3MQB MI TTK0O6Y DMU3MQB MN Ecto-5'-nucleotidase (CD73) DMU3MQB MT DTT DMU3MQB MA Inhibitor DMU3MQB RN Ectonucleotidase inhibitors: a patent review (2011-2016).Expert Opin Ther Pat. 2017 Dec;27(12):1291-1304. DMU3MQB RU https://www.ncbi.nlm.nih.gov/pubmed/28870136 DMFDERP DI DMFDERP DMFDERP DN PMID28870136-Compound-52 DMFDERP MI TTK0O6Y DMFDERP MN Ecto-5'-nucleotidase (CD73) DMFDERP MT DTT DMFDERP MA Inhibitor DMFDERP RN Ectonucleotidase inhibitors: a patent review (2011-2016).Expert Opin Ther Pat. 2017 Dec;27(12):1291-1304. DMFDERP RU https://www.ncbi.nlm.nih.gov/pubmed/28870136 DMLEWY6 DI DMLEWY6 DMLEWY6 DN PMID28870136-Compound-53 DMLEWY6 MI TTK0O6Y DMLEWY6 MN Ecto-5'-nucleotidase (CD73) DMLEWY6 MT DTT DMLEWY6 MA Inhibitor DMLEWY6 RN Ectonucleotidase inhibitors: a patent review (2011-2016).Expert Opin Ther Pat. 2017 Dec;27(12):1291-1304. DMLEWY6 RU https://www.ncbi.nlm.nih.gov/pubmed/28870136 DM6HOES DI DM6HOES DM6HOES DN PMID28870136-Compound-54 DM6HOES MI TTK0O6Y DM6HOES MN Ecto-5'-nucleotidase (CD73) DM6HOES MT DTT DM6HOES MA Inhibitor DM6HOES RN Ectonucleotidase inhibitors: a patent review (2011-2016).Expert Opin Ther Pat. 2017 Dec;27(12):1291-1304. DM6HOES RU https://www.ncbi.nlm.nih.gov/pubmed/28870136 DMVRJZX DI DMVRJZX DMVRJZX DN PMID28870136-Compound-55 DMVRJZX MI TTK0O6Y DMVRJZX MN Ecto-5'-nucleotidase (CD73) DMVRJZX MT DTT DMVRJZX MA Inhibitor DMVRJZX RN Ectonucleotidase inhibitors: a patent review (2011-2016).Expert Opin Ther Pat. 2017 Dec;27(12):1291-1304. DMVRJZX RU https://www.ncbi.nlm.nih.gov/pubmed/28870136 DMK0RTV DI DMK0RTV DMK0RTV DN PMID28870136-Compound-56 DMK0RTV MI TTK0O6Y DMK0RTV MN Ecto-5'-nucleotidase (CD73) DMK0RTV MT DTT DMK0RTV MA Inhibitor DMK0RTV RN Ectonucleotidase inhibitors: a patent review (2011-2016).Expert Opin Ther Pat. 2017 Dec;27(12):1291-1304. DMK0RTV RU https://www.ncbi.nlm.nih.gov/pubmed/28870136 DME3HLC DI DME3HLC DME3HLC DN PMID28870136-Compound-57 DME3HLC MI TTK0O6Y DME3HLC MN Ecto-5'-nucleotidase (CD73) DME3HLC MT DTT DME3HLC MA Inhibitor DME3HLC RN Ectonucleotidase inhibitors: a patent review (2011-2016).Expert Opin Ther Pat. 2017 Dec;27(12):1291-1304. DME3HLC RU https://www.ncbi.nlm.nih.gov/pubmed/28870136 DMQIUD9 DI DMQIUD9 DMQIUD9 DN PMID28870136-Compound-58 DMQIUD9 MI TTK0O6Y DMQIUD9 MN Ecto-5'-nucleotidase (CD73) DMQIUD9 MT DTT DMQIUD9 MA Inhibitor DMQIUD9 RN Ectonucleotidase inhibitors: a patent review (2011-2016).Expert Opin Ther Pat. 2017 Dec;27(12):1291-1304. DMQIUD9 RU https://www.ncbi.nlm.nih.gov/pubmed/28870136 DMHP90Q DI DMHP90Q DMHP90Q DN PMID28870136-Compound-59 DMHP90Q MI TTK0O6Y DMHP90Q MN Ecto-5'-nucleotidase (CD73) DMHP90Q MT DTT DMHP90Q MA Inhibitor DMHP90Q RN Ectonucleotidase inhibitors: a patent review (2011-2016).Expert Opin Ther Pat. 2017 Dec;27(12):1291-1304. DMHP90Q RU https://www.ncbi.nlm.nih.gov/pubmed/28870136 DM39QU8 DI DM39QU8 DM39QU8 DN PMID28870136-Compound-60 DM39QU8 MI TTK0O6Y DM39QU8 MN Ecto-5'-nucleotidase (CD73) DM39QU8 MT DTT DM39QU8 MA Inhibitor DM39QU8 RN Ectonucleotidase inhibitors: a patent review (2011-2016).Expert Opin Ther Pat. 2017 Dec;27(12):1291-1304. DM39QU8 RU https://www.ncbi.nlm.nih.gov/pubmed/28870136 DMFNU9D DI DMFNU9D DMFNU9D DN PMID28870136-Compound-61 DMFNU9D MI TTK0O6Y DMFNU9D MN Ecto-5'-nucleotidase (CD73) DMFNU9D MT DTT DMFNU9D MA Inhibitor DMFNU9D RN Ectonucleotidase inhibitors: a patent review (2011-2016).Expert Opin Ther Pat. 2017 Dec;27(12):1291-1304. DMFNU9D RU https://www.ncbi.nlm.nih.gov/pubmed/28870136 DMNKXJ2 DI DMNKXJ2 DMNKXJ2 DN PMID28870136-Compound-62 DMNKXJ2 MI TTK0O6Y DMNKXJ2 MN Ecto-5'-nucleotidase (CD73) DMNKXJ2 MT DTT DMNKXJ2 MA Inhibitor DMNKXJ2 RN Ectonucleotidase inhibitors: a patent review (2011-2016).Expert Opin Ther Pat. 2017 Dec;27(12):1291-1304. DMNKXJ2 RU https://www.ncbi.nlm.nih.gov/pubmed/28870136 DM26WNY DI DM26WNY DM26WNY DN PMID28870136-Compound-63 DM26WNY MI TTK0O6Y DM26WNY MN Ecto-5'-nucleotidase (CD73) DM26WNY MT DTT DM26WNY MA Inhibitor DM26WNY RN Ectonucleotidase inhibitors: a patent review (2011-2016).Expert Opin Ther Pat. 2017 Dec;27(12):1291-1304. DM26WNY RU https://www.ncbi.nlm.nih.gov/pubmed/28870136 DMBKSVH DI DMBKSVH DMBKSVH DN PMID28870136-Compound-64 DMBKSVH MI TTK0O6Y DMBKSVH MN Ecto-5'-nucleotidase (CD73) DMBKSVH MT DTT DMBKSVH MA Inhibitor DMBKSVH RN Ectonucleotidase inhibitors: a patent review (2011-2016).Expert Opin Ther Pat. 2017 Dec;27(12):1291-1304. DMBKSVH RU https://www.ncbi.nlm.nih.gov/pubmed/28870136 DMF5K9J DI DMF5K9J DMF5K9J DN PMID28870136-Compound-65 DMF5K9J MI TTK0O6Y DMF5K9J MN Ecto-5'-nucleotidase (CD73) DMF5K9J MT DTT DMF5K9J MA Inhibitor DMF5K9J RN Ectonucleotidase inhibitors: a patent review (2011-2016).Expert Opin Ther Pat. 2017 Dec;27(12):1291-1304. DMF5K9J RU https://www.ncbi.nlm.nih.gov/pubmed/28870136 DME3YRI DI DME3YRI DME3YRI DN PMID28870136-Compound-67 DME3YRI MI TTK0O6Y DME3YRI MN Ecto-5'-nucleotidase (CD73) DME3YRI MT DTT DME3YRI MA Inhibitor DME3YRI RN Ectonucleotidase inhibitors: a patent review (2011-2016).Expert Opin Ther Pat. 2017 Dec;27(12):1291-1304. DME3YRI RU https://www.ncbi.nlm.nih.gov/pubmed/28870136 DMFTM8X DI DMFTM8X DMFTM8X DN PMID28870136-Compound-68 DMFTM8X MI TTK0O6Y DMFTM8X MN Ecto-5'-nucleotidase (CD73) DMFTM8X MT DTT DMFTM8X MA Inhibitor DMFTM8X RN Ectonucleotidase inhibitors: a patent review (2011-2016).Expert Opin Ther Pat. 2017 Dec;27(12):1291-1304. DMFTM8X RU https://www.ncbi.nlm.nih.gov/pubmed/28870136 DMVCQKB DI DMVCQKB DMVCQKB DN PMID28870136-Compound-69 DMVCQKB MI TTK0O6Y DMVCQKB MN Ecto-5'-nucleotidase (CD73) DMVCQKB MT DTT DMVCQKB MA Inhibitor DMVCQKB RN Ectonucleotidase inhibitors: a patent review (2011-2016).Expert Opin Ther Pat. 2017 Dec;27(12):1291-1304. DMVCQKB RU https://www.ncbi.nlm.nih.gov/pubmed/28870136 DMECU90 DI DMECU90 DMECU90 DN PMID28906174-Compound-figure1g DMECU90 MI TTSCIUP DMECU90 MN Oxytocin receptor (OTR) DMECU90 MT DTT DMECU90 MA Antagonist DMECU90 RN A patent review of oxytocin receptor antagonists 2013-2017.Expert Opin Ther Pat. 2017 Dec;27(12):1287-1290. DMECU90 RU https://www.ncbi.nlm.nih.gov/pubmed/28906174 DMECU90 DI DMECU90 DMECU90 DN PMID28906174-Compound-figure1g DMECU90 MI TT4TFGN DMECU90 MN Vasopressin V1a receptor (V1AR) DMECU90 MT DTT DMECU90 MA Antagonist DMECU90 RN A patent review of oxytocin receptor antagonists 2013-2017.Expert Opin Ther Pat. 2017 Dec;27(12):1287-1290. DMECU90 RU https://www.ncbi.nlm.nih.gov/pubmed/28906174 DMLMHR5 DI DMLMHR5 DMLMHR5 DN PMID29053063-Compound-11c DMLMHR5 MI TTSINOV DMLMHR5 MN Monoacylglycerol lipase ABHD6 (ABHD6) DMLMHR5 MT DTT DMLMHR5 MA Inhibitor DMLMHR5 RN A patent review of Monoacylglycerol Lipase (MAGL) inhibitors (2013-2017).Expert Opin Ther Pat. 2017 Dec;27(12):1341-1351. DMLMHR5 RU https://www.ncbi.nlm.nih.gov/pubmed/29053063 DMLMHR5 DI DMLMHR5 DMLMHR5 DN PMID29053063-Compound-11c DMLMHR5 MI TTZ963I DMLMHR5 MN Monoglyceride lipase (MAGL) DMLMHR5 MT DTT DMLMHR5 MA Inhibitor DMLMHR5 RN A patent review of Monoacylglycerol Lipase (MAGL) inhibitors (2013-2017).Expert Opin Ther Pat. 2017 Dec;27(12):1341-1351. DMLMHR5 RU https://www.ncbi.nlm.nih.gov/pubmed/29053063 DMDRK68 DI DMDRK68 DMDRK68 DN PMID29053063-Compound-11d DMDRK68 MI TTDP1UC DMDRK68 MN Fatty acid amide hydrolase (FAAH) DMDRK68 MT DTT DMDRK68 MA Inhibitor DMDRK68 RN A patent review of Monoacylglycerol Lipase (MAGL) inhibitors (2013-2017).Expert Opin Ther Pat. 2017 Dec;27(12):1341-1351. DMDRK68 RU https://www.ncbi.nlm.nih.gov/pubmed/29053063 DMDRK68 DI DMDRK68 DMDRK68 DN PMID29053063-Compound-11d DMDRK68 MI TTSINOV DMDRK68 MN Monoacylglycerol lipase ABHD6 (ABHD6) DMDRK68 MT DTT DMDRK68 MA Inhibitor DMDRK68 RN A patent review of Monoacylglycerol Lipase (MAGL) inhibitors (2013-2017).Expert Opin Ther Pat. 2017 Dec;27(12):1341-1351. DMDRK68 RU https://www.ncbi.nlm.nih.gov/pubmed/29053063 DMDRK68 DI DMDRK68 DMDRK68 DN PMID29053063-Compound-11d DMDRK68 MI TTZ963I DMDRK68 MN Monoglyceride lipase (MAGL) DMDRK68 MT DTT DMDRK68 MA Inhibitor DMDRK68 RN A patent review of Monoacylglycerol Lipase (MAGL) inhibitors (2013-2017).Expert Opin Ther Pat. 2017 Dec;27(12):1341-1351. DMDRK68 RU https://www.ncbi.nlm.nih.gov/pubmed/29053063 DMBR72X DI DMBR72X DMBR72X DN PMID29053063-Compound-14 DMBR72X MI TTDP1UC DMBR72X MN Fatty acid amide hydrolase (FAAH) DMBR72X MT DTT DMBR72X MA Inhibitor DMBR72X RN A patent review of Monoacylglycerol Lipase (MAGL) inhibitors (2013-2017).Expert Opin Ther Pat. 2017 Dec;27(12):1341-1351. DMBR72X RU https://www.ncbi.nlm.nih.gov/pubmed/29053063 DMBR72X DI DMBR72X DMBR72X DN PMID29053063-Compound-14 DMBR72X MI TTZ963I DMBR72X MN Monoglyceride lipase (MAGL) DMBR72X MT DTT DMBR72X MA Inhibitor DMBR72X RN A patent review of Monoacylglycerol Lipase (MAGL) inhibitors (2013-2017).Expert Opin Ther Pat. 2017 Dec;27(12):1341-1351. DMBR72X RU https://www.ncbi.nlm.nih.gov/pubmed/29053063 DM07U5R DI DM07U5R DM07U5R DN PMID29053063-Compound-15 DM07U5R MI TTRQ6UD DM07U5R MN Diacylglycerol lipase alpha (DAGLA) DM07U5R MT DTT DM07U5R MA Inhibitor DM07U5R RN A patent review of Monoacylglycerol Lipase (MAGL) inhibitors (2013-2017).Expert Opin Ther Pat. 2017 Dec;27(12):1341-1351. DM07U5R RU https://www.ncbi.nlm.nih.gov/pubmed/29053063 DM07U5R DI DM07U5R DM07U5R DN PMID29053063-Compound-15 DM07U5R MI TTDP1UC DM07U5R MN Fatty acid amide hydrolase (FAAH) DM07U5R MT DTT DM07U5R MA Inhibitor DM07U5R RN A patent review of Monoacylglycerol Lipase (MAGL) inhibitors (2013-2017).Expert Opin Ther Pat. 2017 Dec;27(12):1341-1351. DM07U5R RU https://www.ncbi.nlm.nih.gov/pubmed/29053063 DM07U5R DI DM07U5R DM07U5R DN PMID29053063-Compound-15 DM07U5R MI TTZ963I DM07U5R MN Monoglyceride lipase (MAGL) DM07U5R MT DTT DM07U5R MA Inhibitor DM07U5R RN A patent review of Monoacylglycerol Lipase (MAGL) inhibitors (2013-2017).Expert Opin Ther Pat. 2017 Dec;27(12):1341-1351. DM07U5R RU https://www.ncbi.nlm.nih.gov/pubmed/29053063 DMRHPN0 DI DMRHPN0 DMRHPN0 DN PMID29053063-Compound-17 DMRHPN0 MI TTZ963I DMRHPN0 MN Monoglyceride lipase (MAGL) DMRHPN0 MT DTT DMRHPN0 MA Inhibitor DMRHPN0 RN A patent review of Monoacylglycerol Lipase (MAGL) inhibitors (2013-2017).Expert Opin Ther Pat. 2017 Dec;27(12):1341-1351. DMRHPN0 RU https://www.ncbi.nlm.nih.gov/pubmed/29053063 DM8RAK0 DI DM8RAK0 DM8RAK0 DN PMID29053063-Compound-4 DM8RAK0 MI TTZ963I DM8RAK0 MN Monoglyceride lipase (MAGL) DM8RAK0 MT DTT DM8RAK0 MA Inhibitor DM8RAK0 RN A patent review of Monoacylglycerol Lipase (MAGL) inhibitors (2013-2017).Expert Opin Ther Pat. 2017 Dec;27(12):1341-1351. DM8RAK0 RU https://www.ncbi.nlm.nih.gov/pubmed/29053063 DM2P05S DI DM2P05S DM2P05S DN PMID29053063-Compound-5 DM2P05S MI TTZ963I DM2P05S MN Monoglyceride lipase (MAGL) DM2P05S MT DTT DM2P05S MA Inhibitor DM2P05S RN A patent review of Monoacylglycerol Lipase (MAGL) inhibitors (2013-2017).Expert Opin Ther Pat. 2017 Dec;27(12):1341-1351. DM2P05S RU https://www.ncbi.nlm.nih.gov/pubmed/29053063 DMTOHNQ DI DMTOHNQ DMTOHNQ DN PMID29053063-Compound-7a DMTOHNQ MI TTZ963I DMTOHNQ MN Monoglyceride lipase (MAGL) DMTOHNQ MT DTT DMTOHNQ MA Inhibitor DMTOHNQ RN A patent review of Monoacylglycerol Lipase (MAGL) inhibitors (2013-2017).Expert Opin Ther Pat. 2017 Dec;27(12):1341-1351. DMTOHNQ RU https://www.ncbi.nlm.nih.gov/pubmed/29053063 DMDJ6O8 DI DMDJ6O8 DMDJ6O8 DN PMID29053063-Compound-7b DMDJ6O8 MI TTZ963I DMDJ6O8 MN Monoglyceride lipase (MAGL) DMDJ6O8 MT DTT DMDJ6O8 MA Inhibitor DMDJ6O8 RN A patent review of Monoacylglycerol Lipase (MAGL) inhibitors (2013-2017).Expert Opin Ther Pat. 2017 Dec;27(12):1341-1351. DMDJ6O8 RU https://www.ncbi.nlm.nih.gov/pubmed/29053063 DMNZO7V DI DMNZO7V DMNZO7V DN PMID29053063-Compound-7c DMNZO7V MI TTZ963I DMNZO7V MN Monoglyceride lipase (MAGL) DMNZO7V MT DTT DMNZO7V MA Inhibitor DMNZO7V RN A patent review of Monoacylglycerol Lipase (MAGL) inhibitors (2013-2017).Expert Opin Ther Pat. 2017 Dec;27(12):1341-1351. DMNZO7V RU https://www.ncbi.nlm.nih.gov/pubmed/29053063 DMUNXAR DI DMUNXAR DMUNXAR DN PMID29053063-Compound-7d DMUNXAR MI TTZ963I DMUNXAR MN Monoglyceride lipase (MAGL) DMUNXAR MT DTT DMUNXAR MA Inhibitor DMUNXAR RN A patent review of Monoacylglycerol Lipase (MAGL) inhibitors (2013-2017).Expert Opin Ther Pat. 2017 Dec;27(12):1341-1351. DMUNXAR RU https://www.ncbi.nlm.nih.gov/pubmed/29053063 DM6XYFB DI DM6XYFB DM6XYFB DN PMID29053063-Compound-7e DM6XYFB MI TTZ963I DM6XYFB MN Monoglyceride lipase (MAGL) DM6XYFB MT DTT DM6XYFB MA Inhibitor DM6XYFB RN A patent review of Monoacylglycerol Lipase (MAGL) inhibitors (2013-2017).Expert Opin Ther Pat. 2017 Dec;27(12):1341-1351. DM6XYFB RU https://www.ncbi.nlm.nih.gov/pubmed/29053063 DMIQ263 DI DMIQ263 DMIQ263 DN PMID29053063-Compound-7f DMIQ263 MI TTZ963I DMIQ263 MN Monoglyceride lipase (MAGL) DMIQ263 MT DTT DMIQ263 MA Inhibitor DMIQ263 RN A patent review of Monoacylglycerol Lipase (MAGL) inhibitors (2013-2017).Expert Opin Ther Pat. 2017 Dec;27(12):1341-1351. DMIQ263 RU https://www.ncbi.nlm.nih.gov/pubmed/29053063 DMFWXPS DI DMFWXPS DMFWXPS DN PMID29130358-Compound-Figure10(2a) DMFWXPS MI TTMX39J DMFWXPS MN Matrix metalloproteinase-1 (MMP-1) DMFWXPS MT DTT DMFWXPS MA Inhibitor DMFWXPS RN Gelatinase inhibitors: a patent review (2011-2017).Expert Opin Ther Pat. 2018 Jan;28(1):31-46. DMFWXPS RU https://www.ncbi.nlm.nih.gov/pubmed/29130358 DMFWXPS DI DMFWXPS DMFWXPS DN PMID29130358-Compound-Figure10(2a) DMFWXPS MI TTLM12X DMFWXPS MN Matrix metalloproteinase-2 (MMP-2) DMFWXPS MT DTT DMFWXPS MA Inhibitor DMFWXPS RN Gelatinase inhibitors: a patent review (2011-2017).Expert Opin Ther Pat. 2018 Jan;28(1):31-46. DMFWXPS RU https://www.ncbi.nlm.nih.gov/pubmed/29130358 DMFWXPS DI DMFWXPS DMFWXPS DN PMID29130358-Compound-Figure10(2a) DMFWXPS MI TTUZ2L5 DMFWXPS MN Matrix metalloproteinase-3 (MMP-3) DMFWXPS MT DTT DMFWXPS MA Inhibitor DMFWXPS RN Gelatinase inhibitors: a patent review (2011-2017).Expert Opin Ther Pat. 2018 Jan;28(1):31-46. DMFWXPS RU https://www.ncbi.nlm.nih.gov/pubmed/29130358 DMSME2B DI DMSME2B DMSME2B DN PMID29130358-Compound-Figure11(3) DMSME2B MI TTLM12X DMSME2B MN Matrix metalloproteinase-2 (MMP-2) DMSME2B MT DTT DMSME2B MA Inhibitor DMSME2B RN Gelatinase inhibitors: a patent review (2011-2017).Expert Opin Ther Pat. 2018 Jan;28(1):31-46. DMSME2B RU https://www.ncbi.nlm.nih.gov/pubmed/29130358 DMSME2B DI DMSME2B DMSME2B DN PMID29130358-Compound-Figure11(3) DMSME2B MI TTULVH8 DMSME2B MN Tyrosinase (TYR) DMSME2B MT DTT DMSME2B MA Inhibitor DMSME2B RN Gelatinase inhibitors: a patent review (2011-2017).Expert Opin Ther Pat. 2018 Jan;28(1):31-46. DMSME2B RU https://www.ncbi.nlm.nih.gov/pubmed/29130358 DMDFPIO DI DMDFPIO DMDFPIO DN PMID29130358-Compound-Figure13(4) DMDFPIO MI TTLM12X DMDFPIO MN Matrix metalloproteinase-2 (MMP-2) DMDFPIO MT DTT DMDFPIO MA Inhibitor DMDFPIO RN Gelatinase inhibitors: a patent review (2011-2017).Expert Opin Ther Pat. 2018 Jan;28(1):31-46. DMDFPIO RU https://www.ncbi.nlm.nih.gov/pubmed/29130358 DMDFPIO DI DMDFPIO DMDFPIO DN PMID29130358-Compound-Figure13(4) DMDFPIO MI TT6X50U DMDFPIO MN Matrix metalloproteinase-9 (MMP-9) DMDFPIO MT DTT DMDFPIO MA Inhibitor DMDFPIO RN Gelatinase inhibitors: a patent review (2011-2017).Expert Opin Ther Pat. 2018 Jan;28(1):31-46. DMDFPIO RU https://www.ncbi.nlm.nih.gov/pubmed/29130358 DMB6KS9 DI DMB6KS9 DMB6KS9 DN PMID29130358-Compound-Figure14(5) DMB6KS9 MI TTXPTJE DMB6KS9 MN Gelatinase (GEL) DMB6KS9 MT DTT DMB6KS9 MA Inhibitor DMB6KS9 RN Gelatinase inhibitors: a patent review (2011-2017).Expert Opin Ther Pat. 2018 Jan;28(1):31-46. DMB6KS9 RU https://www.ncbi.nlm.nih.gov/pubmed/29130358 DMFMJIN DI DMFMJIN DMFMJIN DN PMID29130358-Compound-Figure14(6) DMFMJIN MI TTXPTJE DMFMJIN MN Gelatinase (GEL) DMFMJIN MT DTT DMFMJIN MA Inhibitor DMFMJIN RN Gelatinase inhibitors: a patent review (2011-2017).Expert Opin Ther Pat. 2018 Jan;28(1):31-46. DMFMJIN RU https://www.ncbi.nlm.nih.gov/pubmed/29130358 DM85ETX DI DM85ETX DM85ETX DN PMID29130358-Compound-Figure15(7) DM85ETX MI TTXPTJE DM85ETX MN Gelatinase (GEL) DM85ETX MT DTT DM85ETX MA Inhibitor DM85ETX RN Gelatinase inhibitors: a patent review (2011-2017).Expert Opin Ther Pat. 2018 Jan;28(1):31-46. DM85ETX RU https://www.ncbi.nlm.nih.gov/pubmed/29130358 DML8FUD DI DML8FUD DML8FUD DN PMID29130358-Compound-Figure15(8) DML8FUD MI TTXPTJE DML8FUD MN Gelatinase (GEL) DML8FUD MT DTT DML8FUD MA Inhibitor DML8FUD RN Gelatinase inhibitors: a patent review (2011-2017).Expert Opin Ther Pat. 2018 Jan;28(1):31-46. DML8FUD RU https://www.ncbi.nlm.nih.gov/pubmed/29130358 DMKX5R8 DI DMKX5R8 DMKX5R8 DN PMID29130358-Compound-Figure16(9a) DMKX5R8 MI TTHY57M DMKX5R8 MN Matrix metalloproteinase-13 (MMP-13) DMKX5R8 MT DTT DMKX5R8 MA Inhibitor DMKX5R8 RN Gelatinase inhibitors: a patent review (2011-2017).Expert Opin Ther Pat. 2018 Jan;28(1):31-46. DMKX5R8 RU https://www.ncbi.nlm.nih.gov/pubmed/29130358 DMKX5R8 DI DMKX5R8 DMKX5R8 DN PMID29130358-Compound-Figure16(9a) DMKX5R8 MI TTLM12X DMKX5R8 MN Matrix metalloproteinase-2 (MMP-2) DMKX5R8 MT DTT DMKX5R8 MA Inhibitor DMKX5R8 RN Gelatinase inhibitors: a patent review (2011-2017).Expert Opin Ther Pat. 2018 Jan;28(1):31-46. DMKX5R8 RU https://www.ncbi.nlm.nih.gov/pubmed/29130358 DMPAQLZ DI DMPAQLZ DMPAQLZ DN PMID29130358-Compound-Figure16(9b) DMPAQLZ MI TTHY57M DMPAQLZ MN Matrix metalloproteinase-13 (MMP-13) DMPAQLZ MT DTT DMPAQLZ MA Inhibitor DMPAQLZ RN Gelatinase inhibitors: a patent review (2011-2017).Expert Opin Ther Pat. 2018 Jan;28(1):31-46. DMPAQLZ RU https://www.ncbi.nlm.nih.gov/pubmed/29130358 DMPAQLZ DI DMPAQLZ DMPAQLZ DN PMID29130358-Compound-Figure16(9b) DMPAQLZ MI TTLM12X DMPAQLZ MN Matrix metalloproteinase-2 (MMP-2) DMPAQLZ MT DTT DMPAQLZ MA Inhibitor DMPAQLZ RN Gelatinase inhibitors: a patent review (2011-2017).Expert Opin Ther Pat. 2018 Jan;28(1):31-46. DMPAQLZ RU https://www.ncbi.nlm.nih.gov/pubmed/29130358 DM0ZRI9 DI DM0ZRI9 DM0ZRI9 DN PMID29130358-Compound-Figure16(9c) DM0ZRI9 MI TTHY57M DM0ZRI9 MN Matrix metalloproteinase-13 (MMP-13) DM0ZRI9 MT DTT DM0ZRI9 MA Inhibitor DM0ZRI9 RN Gelatinase inhibitors: a patent review (2011-2017).Expert Opin Ther Pat. 2018 Jan;28(1):31-46. DM0ZRI9 RU https://www.ncbi.nlm.nih.gov/pubmed/29130358 DM0ZRI9 DI DM0ZRI9 DM0ZRI9 DN PMID29130358-Compound-Figure16(9c) DM0ZRI9 MI TTLM12X DM0ZRI9 MN Matrix metalloproteinase-2 (MMP-2) DM0ZRI9 MT DTT DM0ZRI9 MA Inhibitor DM0ZRI9 RN Gelatinase inhibitors: a patent review (2011-2017).Expert Opin Ther Pat. 2018 Jan;28(1):31-46. DM0ZRI9 RU https://www.ncbi.nlm.nih.gov/pubmed/29130358 DMVA15O DI DMVA15O DMVA15O DN PMID29130358-Compound-Figure17(10) DMVA15O MI TTXZ0KQ DMVA15O MN Matrix metalloproteinase-12 (MMP-12) DMVA15O MT DTT DMVA15O MA Inhibitor DMVA15O RN Gelatinase inhibitors: a patent review (2011-2017).Expert Opin Ther Pat. 2018 Jan;28(1):31-46. DMVA15O RU https://www.ncbi.nlm.nih.gov/pubmed/29130358 DMVA15O DI DMVA15O DMVA15O DN PMID29130358-Compound-Figure17(10) DMVA15O MI TT6X50U DMVA15O MN Matrix metalloproteinase-9 (MMP-9) DMVA15O MT DTT DMVA15O MA Inhibitor DMVA15O RN Gelatinase inhibitors: a patent review (2011-2017).Expert Opin Ther Pat. 2018 Jan;28(1):31-46. DMVA15O RU https://www.ncbi.nlm.nih.gov/pubmed/29130358 DMSZA9L DI DMSZA9L DMSZA9L DN PMID29130358-Compound-Figure17(11) DMSZA9L MI TTXZ0KQ DMSZA9L MN Matrix metalloproteinase-12 (MMP-12) DMSZA9L MT DTT DMSZA9L MA Inhibitor DMSZA9L RN Gelatinase inhibitors: a patent review (2011-2017).Expert Opin Ther Pat. 2018 Jan;28(1):31-46. DMSZA9L RU https://www.ncbi.nlm.nih.gov/pubmed/29130358 DMSZA9L DI DMSZA9L DMSZA9L DN PMID29130358-Compound-Figure17(11) DMSZA9L MI TT6X50U DMSZA9L MN Matrix metalloproteinase-9 (MMP-9) DMSZA9L MT DTT DMSZA9L MA Inhibitor DMSZA9L RN Gelatinase inhibitors: a patent review (2011-2017).Expert Opin Ther Pat. 2018 Jan;28(1):31-46. DMSZA9L RU https://www.ncbi.nlm.nih.gov/pubmed/29130358 DMML4PA DI DMML4PA DMML4PA DN PMID29130358-Compound-Figure17(12) DMML4PA MI TTXZ0KQ DMML4PA MN Matrix metalloproteinase-12 (MMP-12) DMML4PA MT DTT DMML4PA MA Inhibitor DMML4PA RN Gelatinase inhibitors: a patent review (2011-2017).Expert Opin Ther Pat. 2018 Jan;28(1):31-46. DMML4PA RU https://www.ncbi.nlm.nih.gov/pubmed/29130358 DMML4PA DI DMML4PA DMML4PA DN PMID29130358-Compound-Figure17(12) DMML4PA MI TT6X50U DMML4PA MN Matrix metalloproteinase-9 (MMP-9) DMML4PA MT DTT DMML4PA MA Inhibitor DMML4PA RN Gelatinase inhibitors: a patent review (2011-2017).Expert Opin Ther Pat. 2018 Jan;28(1):31-46. DMML4PA RU https://www.ncbi.nlm.nih.gov/pubmed/29130358 DM2QRIW DI DM2QRIW DM2QRIW DN PMID29130358-Compound-Figure17(13) DM2QRIW MI TT6X50U DM2QRIW MN Matrix metalloproteinase-9 (MMP-9) DM2QRIW MT DTT DM2QRIW MA Inhibitor DM2QRIW RN Gelatinase inhibitors: a patent review (2011-2017).Expert Opin Ther Pat. 2018 Jan;28(1):31-46. DM2QRIW RU https://www.ncbi.nlm.nih.gov/pubmed/29130358 DM7WXJ9 DI DM7WXJ9 DM7WXJ9 DN PMID29130358-Compound-Figure18(14) DM7WXJ9 MI TTHY57M DM7WXJ9 MN Matrix metalloproteinase-13 (MMP-13) DM7WXJ9 MT DTT DM7WXJ9 MA Inhibitor DM7WXJ9 RN Gelatinase inhibitors: a patent review (2011-2017).Expert Opin Ther Pat. 2018 Jan;28(1):31-46. DM7WXJ9 RU https://www.ncbi.nlm.nih.gov/pubmed/29130358 DM7WXJ9 DI DM7WXJ9 DM7WXJ9 DN PMID29130358-Compound-Figure18(14) DM7WXJ9 MI TTLM12X DM7WXJ9 MN Matrix metalloproteinase-2 (MMP-2) DM7WXJ9 MT DTT DM7WXJ9 MA Inhibitor DM7WXJ9 RN Gelatinase inhibitors: a patent review (2011-2017).Expert Opin Ther Pat. 2018 Jan;28(1):31-46. DM7WXJ9 RU https://www.ncbi.nlm.nih.gov/pubmed/29130358 DMHIBTZ DI DMHIBTZ DMHIBTZ DN PMID29130358-Compound-Figure18(14a) DMHIBTZ MI TTMX39J DMHIBTZ MN Matrix metalloproteinase-1 (MMP-1) DMHIBTZ MT DTT DMHIBTZ MA Inhibitor DMHIBTZ RN Gelatinase inhibitors: a patent review (2011-2017).Expert Opin Ther Pat. 2018 Jan;28(1):31-46. DMHIBTZ RU https://www.ncbi.nlm.nih.gov/pubmed/29130358 DMHIBTZ DI DMHIBTZ DMHIBTZ DN PMID29130358-Compound-Figure18(14a) DMHIBTZ MI TTHY57M DMHIBTZ MN Matrix metalloproteinase-13 (MMP-13) DMHIBTZ MT DTT DMHIBTZ MA Inhibitor DMHIBTZ RN Gelatinase inhibitors: a patent review (2011-2017).Expert Opin Ther Pat. 2018 Jan;28(1):31-46. DMHIBTZ RU https://www.ncbi.nlm.nih.gov/pubmed/29130358 DMHIBTZ DI DMHIBTZ DMHIBTZ DN PMID29130358-Compound-Figure18(14a) DMHIBTZ MI TTLM12X DMHIBTZ MN Matrix metalloproteinase-2 (MMP-2) DMHIBTZ MT DTT DMHIBTZ MA Inhibitor DMHIBTZ RN Gelatinase inhibitors: a patent review (2011-2017).Expert Opin Ther Pat. 2018 Jan;28(1):31-46. DMHIBTZ RU https://www.ncbi.nlm.nih.gov/pubmed/29130358 DMHIBTZ DI DMHIBTZ DMHIBTZ DN PMID29130358-Compound-Figure18(14a) DMHIBTZ MI TT6X50U DMHIBTZ MN Matrix metalloproteinase-9 (MMP-9) DMHIBTZ MT DTT DMHIBTZ MA Inhibitor DMHIBTZ RN Gelatinase inhibitors: a patent review (2011-2017).Expert Opin Ther Pat. 2018 Jan;28(1):31-46. DMHIBTZ RU https://www.ncbi.nlm.nih.gov/pubmed/29130358 DMMX5I6 DI DMMX5I6 DMMX5I6 DN PMID29130358-Compound-Figure9(1) DMMX5I6 MI TTXPTJE DMMX5I6 MN Gelatinase (GEL) DMMX5I6 MT DTT DMMX5I6 MA Inhibitor DMMX5I6 RN Gelatinase inhibitors: a patent review (2011-2017).Expert Opin Ther Pat. 2018 Jan;28(1):31-46. DMMX5I6 RU https://www.ncbi.nlm.nih.gov/pubmed/29130358 DMTJEU5 DI DMTJEU5 DMTJEU5 DN PMID29130358-Compound-LonimacranthoideVI DMTJEU5 MI TTVKILB DMTJEU5 MN Prostaglandin G/H synthase 2 (COX-2) DMTJEU5 MT DTT DMTJEU5 MA Inhibitor DMTJEU5 RN Gelatinase inhibitors: a patent review (2011-2017).Expert Opin Ther Pat. 2018 Jan;28(1):31-46. DMTJEU5 RU https://www.ncbi.nlm.nih.gov/pubmed/29130358 DMOGIAU DI DMOGIAU DMOGIAU DN PMID29130358-Compound-LonimacranthoideVII DMOGIAU MI TTLM12X DMOGIAU MN Matrix metalloproteinase-2 (MMP-2) DMOGIAU MT DTT DMOGIAU MA Inhibitor DMOGIAU RN Gelatinase inhibitors: a patent review (2011-2017).Expert Opin Ther Pat. 2018 Jan;28(1):31-46. DMOGIAU RU https://www.ncbi.nlm.nih.gov/pubmed/29130358 DMOGIAU DI DMOGIAU DMOGIAU DN PMID29130358-Compound-LonimacranthoideVII DMOGIAU MI TT6X50U DMOGIAU MN Matrix metalloproteinase-9 (MMP-9) DMOGIAU MT DTT DMOGIAU MA Inhibitor DMOGIAU RN Gelatinase inhibitors: a patent review (2011-2017).Expert Opin Ther Pat. 2018 Jan;28(1):31-46. DMOGIAU RU https://www.ncbi.nlm.nih.gov/pubmed/29130358 DMC64XQ DI DMC64XQ DMC64XQ DN PMID29130358-Compound-SB-3CT DMC64XQ MI TTLM12X DMC64XQ MN Matrix metalloproteinase-2 (MMP-2) DMC64XQ MT DTT DMC64XQ MA Inhibitor DMC64XQ RN Gelatinase inhibitors: a patent review (2011-2017).Expert Opin Ther Pat. 2018 Jan;28(1):31-46. DMC64XQ RU https://www.ncbi.nlm.nih.gov/pubmed/29130358 DMC64XQ DI DMC64XQ DMC64XQ DN PMID29130358-Compound-SB-3CT DMC64XQ MI TT6X50U DMC64XQ MN Matrix metalloproteinase-9 (MMP-9) DMC64XQ MT DTT DMC64XQ MA Inhibitor DMC64XQ RN Gelatinase inhibitors: a patent review (2011-2017).Expert Opin Ther Pat. 2018 Jan;28(1):31-46. DMC64XQ RU https://www.ncbi.nlm.nih.gov/pubmed/29130358 DMDN4KP DI DMDN4KP DMDN4KP DN PMID29166791-Compound-AMPCP DMDN4KP MI TTK0O6Y DMDN4KP MN Ecto-5'-nucleotidase (CD73) DMDN4KP MT DTT DMDN4KP MA Inhibitor DMDN4KP RN Evaluation of WO2017098421: GSK's benzothiazine compounds as CD73 inhibitor filings.Expert Opin Ther Pat. 2018 Feb;28(2):167-171. DMDN4KP RU https://www.ncbi.nlm.nih.gov/pubmed/29166791 DM0DAR1 DI DM0DAR1 DM0DAR1 DN PMID29324067-Compound-25 DM0DAR1 MI TT3WG5C DM0DAR1 MN Monoamine oxidase type A (MAO-A) DM0DAR1 MT DTT DM0DAR1 MA Inhibitor DM0DAR1 RN MAO inhibitors and their wider applications: a patent review.Expert Opin Ther Pat. 2018 Mar;28(3):211-226. DM0DAR1 RU https://www.ncbi.nlm.nih.gov/pubmed/29324067 DMPXZYN DI DMPXZYN DMPXZYN DN PMID29324067-Compound-38 DMPXZYN MI TTGP7BY DMPXZYN MN Monoamine oxidase type B (MAO-B) DMPXZYN MT DTT DMPXZYN MA Inhibitor DMPXZYN RN MAO inhibitors and their wider applications: a patent review.Expert Opin Ther Pat. 2018 Mar;28(3):211-226. DMPXZYN RU https://www.ncbi.nlm.nih.gov/pubmed/29324067 DM69A05 DI DM69A05 DM69A05 DN PMID29324067-Compound-40 DM69A05 MI TTGP7BY DM69A05 MN Monoamine oxidase type B (MAO-B) DM69A05 MT DTT DM69A05 MA Inhibitor DM69A05 RN MAO inhibitors and their wider applications: a patent review.Expert Opin Ther Pat. 2018 Mar;28(3):211-226. DM69A05 RU https://www.ncbi.nlm.nih.gov/pubmed/29324067 DMTOA1Q DI DMTOA1Q DMTOA1Q DN PMID29334795-Compound-21 DMTOA1Q MI TT9JNIC DMTOA1Q MN Histamine H3 receptor (H3R) DMTOA1Q MT DTT DMTOA1Q RN Progress in the development of histamine H3 receptor antagonists/inverse agonists: a patent review (2013-2017).Expert Opin Ther Pat. 2018 Mar;28(3):175-196. DMTOA1Q RU https://www.ncbi.nlm.nih.gov/pubmed/29334795 DM8N10A DI DM8N10A DM8N10A DN PMID29334795-Compound-22 DM8N10A MI TT9JNIC DM8N10A MN Histamine H3 receptor (H3R) DM8N10A MT DTT DM8N10A MA Agonis; Inverse agonist DM8N10A RN Progress in the development of histamine H3 receptor antagonists/inverse agonists: a patent review (2013-2017).Expert Opin Ther Pat. 2018 Mar;28(3):175-196. DM8N10A RU https://www.ncbi.nlm.nih.gov/pubmed/29334795 DM3VL64 DI DM3VL64 DM3VL64 DN PMID29334795-Compound-23 DM3VL64 MI TT9JNIC DM3VL64 MN Histamine H3 receptor (H3R) DM3VL64 MT DTT DM3VL64 MA Inverse agonist DM3VL64 RN Progress in the development of histamine H3 receptor antagonists/inverse agonists: a patent review (2013-2017).Expert Opin Ther Pat. 2018 Mar;28(3):175-196. DM3VL64 RU https://www.ncbi.nlm.nih.gov/pubmed/29334795 DMTUQV0 DI DMTUQV0 DMTUQV0 DN PMID29334795-Compound-24 DMTUQV0 MI TT9JNIC DMTUQV0 MN Histamine H3 receptor (H3R) DMTUQV0 MT DTT DMTUQV0 MA Inverse agonist DMTUQV0 RN Progress in the development of histamine H3 receptor antagonists/inverse agonists: a patent review (2013-2017).Expert Opin Ther Pat. 2018 Mar;28(3):175-196. DMTUQV0 RU https://www.ncbi.nlm.nih.gov/pubmed/29334795 DMGEWVP DI DMGEWVP DMGEWVP DN PMID29334795-Compound-25 DMGEWVP MI TT9JNIC DMGEWVP MN Histamine H3 receptor (H3R) DMGEWVP MT DTT DMGEWVP MA Inverse agonist DMGEWVP RN Progress in the development of histamine H3 receptor antagonists/inverse agonists: a patent review (2013-2017).Expert Opin Ther Pat. 2018 Mar;28(3):175-196. DMGEWVP RU https://www.ncbi.nlm.nih.gov/pubmed/29334795 DM1SWYU DI DM1SWYU DM1SWYU DN PMID29334795-Compound-28 DM1SWYU MI TT9JNIC DM1SWYU MN Histamine H3 receptor (H3R) DM1SWYU MT DTT DM1SWYU RN Progress in the development of histamine H3 receptor antagonists/inverse agonists: a patent review (2013-2017).Expert Opin Ther Pat. 2018 Mar;28(3):175-196. DM1SWYU RU https://www.ncbi.nlm.nih.gov/pubmed/29334795 DMM30LJ DI DMM30LJ DMM30LJ DN PMID29334795-Compound-55 DMM30LJ MI TT9JNIC DMM30LJ MN Histamine H3 receptor (H3R) DMM30LJ MT DTT DMM30LJ RN Progress in the development of histamine H3 receptor antagonists/inverse agonists: a patent review (2013-2017).Expert Opin Ther Pat. 2018 Mar;28(3):175-196. DMM30LJ RU https://www.ncbi.nlm.nih.gov/pubmed/29334795 DMS9Q3U DI DMS9Q3U DMS9Q3U DN PMID29334795-Compound-56 DMS9Q3U MI TT9JNIC DMS9Q3U MN Histamine H3 receptor (H3R) DMS9Q3U MT DTT DMS9Q3U RN Progress in the development of histamine H3 receptor antagonists/inverse agonists: a patent review (2013-2017).Expert Opin Ther Pat. 2018 Mar;28(3):175-196. DMS9Q3U RU https://www.ncbi.nlm.nih.gov/pubmed/29334795 DMGO1PA DI DMGO1PA DMGO1PA DN PMID29334795-Compound-57 DMGO1PA MI TT9JNIC DMGO1PA MN Histamine H3 receptor (H3R) DMGO1PA MT DTT DMGO1PA RN Progress in the development of histamine H3 receptor antagonists/inverse agonists: a patent review (2013-2017).Expert Opin Ther Pat. 2018 Mar;28(3):175-196. DMGO1PA RU https://www.ncbi.nlm.nih.gov/pubmed/29334795 DMB8GHJ DI DMB8GHJ DMB8GHJ DN PMID29334795-Compound-58 DMB8GHJ MI TT9JNIC DMB8GHJ MN Histamine H3 receptor (H3R) DMB8GHJ MT DTT DMB8GHJ RN Progress in the development of histamine H3 receptor antagonists/inverse agonists: a patent review (2013-2017).Expert Opin Ther Pat. 2018 Mar;28(3):175-196. DMB8GHJ RU https://www.ncbi.nlm.nih.gov/pubmed/29334795 DM9H3LI DI DM9H3LI DM9H3LI DN PMID29334795-Compound-61 DM9H3LI MI TTTIBOJ DM9H3LI MN Histamine H1 receptor (H1R) DM9H3LI MT DTT DM9H3LI RN Progress in the development of histamine H3 receptor antagonists/inverse agonists: a patent review (2013-2017).Expert Opin Ther Pat. 2018 Mar;28(3):175-196. DM9H3LI RU https://www.ncbi.nlm.nih.gov/pubmed/29334795 DM9H3LI DI DM9H3LI DM9H3LI DN PMID29334795-Compound-61 DM9H3LI MI TT9JNIC DM9H3LI MN Histamine H3 receptor (H3R) DM9H3LI MT DTT DM9H3LI RN Progress in the development of histamine H3 receptor antagonists/inverse agonists: a patent review (2013-2017).Expert Opin Ther Pat. 2018 Mar;28(3):175-196. DM9H3LI RU https://www.ncbi.nlm.nih.gov/pubmed/29334795 DM9H3LI DI DM9H3LI DM9H3LI DN PMID29334795-Compound-61 DM9H3LI MI TT3ROYC DM9H3LI MN Serotonin transporter (SERT) DM9H3LI MT DTT DM9H3LI RN Progress in the development of histamine H3 receptor antagonists/inverse agonists: a patent review (2013-2017).Expert Opin Ther Pat. 2018 Mar;28(3):175-196. DM9H3LI RU https://www.ncbi.nlm.nih.gov/pubmed/29334795 DMKAFPC DI DMKAFPC DMKAFPC DN PMID29334795-Compound-62 DMKAFPC MI TTEX248 DMKAFPC MN Dopamine D2 receptor (D2R) DMKAFPC MT DTT DMKAFPC MA Ligand DMKAFPC RN Progress in the development of histamine H3 receptor antagonists/inverse agonists: a patent review (2013-2017).Expert Opin Ther Pat. 2018 Mar;28(3):175-196. DMKAFPC RU https://www.ncbi.nlm.nih.gov/pubmed/29334795 DMKAFPC DI DMKAFPC DMKAFPC DN PMID29334795-Compound-62 DMKAFPC MI TT9JNIC DMKAFPC MN Histamine H3 receptor (H3R) DMKAFPC MT DTT DMKAFPC MA Inhibitor DMKAFPC RN Progress in the development of histamine H3 receptor antagonists/inverse agonists: a patent review (2013-2017).Expert Opin Ther Pat. 2018 Mar;28(3):175-196. DMKAFPC RU https://www.ncbi.nlm.nih.gov/pubmed/29334795 DMQOF53 DI DMQOF53 DMQOF53 DN PMID29334795-Compound-66 DMQOF53 MI TTEX248 DMQOF53 MN Dopamine D2 receptor (D2R) DMQOF53 MT DTT DMQOF53 MA Ligand DMQOF53 RN Progress in the development of histamine H3 receptor antagonists/inverse agonists: a patent review (2013-2017).Expert Opin Ther Pat. 2018 Mar;28(3):175-196. DMQOF53 RU https://www.ncbi.nlm.nih.gov/pubmed/29334795 DMQOF53 DI DMQOF53 DMQOF53 DN PMID29334795-Compound-66 DMQOF53 MI TT9JNIC DMQOF53 MN Histamine H3 receptor (H3R) DMQOF53 MT DTT DMQOF53 MA Inhibitor DMQOF53 RN Progress in the development of histamine H3 receptor antagonists/inverse agonists: a patent review (2013-2017).Expert Opin Ther Pat. 2018 Mar;28(3):175-196. DMQOF53 RU https://www.ncbi.nlm.nih.gov/pubmed/29334795 DMC95N7 DI DMC95N7 DMC95N7 DN PMID29334795-Compound-67 DMC95N7 MI TTEX248 DMC95N7 MN Dopamine D2 receptor (D2R) DMC95N7 MT DTT DMC95N7 MA Ligand DMC95N7 RN Progress in the development of histamine H3 receptor antagonists/inverse agonists: a patent review (2013-2017).Expert Opin Ther Pat. 2018 Mar;28(3):175-196. DMC95N7 RU https://www.ncbi.nlm.nih.gov/pubmed/29334795 DMC95N7 DI DMC95N7 DMC95N7 DN PMID29334795-Compound-67 DMC95N7 MI TT9JNIC DMC95N7 MN Histamine H3 receptor (H3R) DMC95N7 MT DTT DMC95N7 MA Inhibitor DMC95N7 RN Progress in the development of histamine H3 receptor antagonists/inverse agonists: a patent review (2013-2017).Expert Opin Ther Pat. 2018 Mar;28(3):175-196. DMC95N7 RU https://www.ncbi.nlm.nih.gov/pubmed/29334795 DMDJFUX DI DMDJFUX DMDJFUX DN PMID29338548-Compound-13 DMDJFUX MI TTHJTF7 DMDJFUX MN Glycine transporter GlyT-1 (SLC6A9) DMDJFUX MT DTT DMDJFUX MA Inhibitor DMDJFUX RN Glycine transporter-1 inhibitors: a patent review (2011-2016).Expert Opin Ther Pat. 2018 Mar;28(3):197-210. DMDJFUX RU https://www.ncbi.nlm.nih.gov/pubmed/29338548 DMXIO9A DI DMXIO9A DMXIO9A DN PMID29338548-Compound-14 DMXIO9A MI TTHJTF7 DMXIO9A MN Glycine transporter GlyT-1 (SLC6A9) DMXIO9A MT DTT DMXIO9A MA Inhibitor DMXIO9A RN Glycine transporter-1 inhibitors: a patent review (2011-2016).Expert Opin Ther Pat. 2018 Mar;28(3):197-210. DMXIO9A RU https://www.ncbi.nlm.nih.gov/pubmed/29338548 DM6J0Z8 DI DM6J0Z8 DM6J0Z8 DN PMID29338548-Compound-15 DM6J0Z8 MI TTHJTF7 DM6J0Z8 MN Glycine transporter GlyT-1 (SLC6A9) DM6J0Z8 MT DTT DM6J0Z8 MA Inhibitor DM6J0Z8 RN Glycine transporter-1 inhibitors: a patent review (2011-2016).Expert Opin Ther Pat. 2018 Mar;28(3):197-210. DM6J0Z8 RU https://www.ncbi.nlm.nih.gov/pubmed/29338548 DMQNVUB DI DMQNVUB DMQNVUB DN PMID29338548-Compound-16 DMQNVUB MI TTHJTF7 DMQNVUB MN Glycine transporter GlyT-1 (SLC6A9) DMQNVUB MT DTT DMQNVUB MA Inhibitor DMQNVUB RN Glycine transporter-1 inhibitors: a patent review (2011-2016).Expert Opin Ther Pat. 2018 Mar;28(3):197-210. DMQNVUB RU https://www.ncbi.nlm.nih.gov/pubmed/29338548 DMFXCPQ DI DMFXCPQ DMFXCPQ DN PMID29338548-Compound-17 DMFXCPQ MI TTHJTF7 DMFXCPQ MN Glycine transporter GlyT-1 (SLC6A9) DMFXCPQ MT DTT DMFXCPQ MA Inhibitor DMFXCPQ RN Glycine transporter-1 inhibitors: a patent review (2011-2016).Expert Opin Ther Pat. 2018 Mar;28(3):197-210. DMFXCPQ RU https://www.ncbi.nlm.nih.gov/pubmed/29338548 DM0XA3D DI DM0XA3D DM0XA3D DN PMID29338548-Compound-18 DM0XA3D MI TTHJTF7 DM0XA3D MN Glycine transporter GlyT-1 (SLC6A9) DM0XA3D MT DTT DM0XA3D MA Inhibitor DM0XA3D RN Glycine transporter-1 inhibitors: a patent review (2011-2016).Expert Opin Ther Pat. 2018 Mar;28(3):197-210. DM0XA3D RU https://www.ncbi.nlm.nih.gov/pubmed/29338548 DMKHTE1 DI DMKHTE1 DMKHTE1 DN PMID29338548-Compound-19 DMKHTE1 MI TTHJTF7 DMKHTE1 MN Glycine transporter GlyT-1 (SLC6A9) DMKHTE1 MT DTT DMKHTE1 MA Inhibitor DMKHTE1 RN Glycine transporter-1 inhibitors: a patent review (2011-2016).Expert Opin Ther Pat. 2018 Mar;28(3):197-210. DMKHTE1 RU https://www.ncbi.nlm.nih.gov/pubmed/29338548 DMZ3EHV DI DMZ3EHV DMZ3EHV DN PMID29338548-Compound-20 DMZ3EHV MI TTHJTF7 DMZ3EHV MN Glycine transporter GlyT-1 (SLC6A9) DMZ3EHV MT DTT DMZ3EHV MA Inhibitor DMZ3EHV RN Glycine transporter-1 inhibitors: a patent review (2011-2016).Expert Opin Ther Pat. 2018 Mar;28(3):197-210. DMZ3EHV RU https://www.ncbi.nlm.nih.gov/pubmed/29338548 DMRTBKC DI DMRTBKC DMRTBKC DN PMID29338548-Compound-21 DMRTBKC MI TTHJTF7 DMRTBKC MN Glycine transporter GlyT-1 (SLC6A9) DMRTBKC MT DTT DMRTBKC MA Inhibitor DMRTBKC RN Glycine transporter-1 inhibitors: a patent review (2011-2016).Expert Opin Ther Pat. 2018 Mar;28(3):197-210. DMRTBKC RU https://www.ncbi.nlm.nih.gov/pubmed/29338548 DMT3AL5 DI DMT3AL5 DMT3AL5 DN PMID29338548-Compound-22 DMT3AL5 MI TTHJTF7 DMT3AL5 MN Glycine transporter GlyT-1 (SLC6A9) DMT3AL5 MT DTT DMT3AL5 MA Inhibitor DMT3AL5 RN Glycine transporter-1 inhibitors: a patent review (2011-2016).Expert Opin Ther Pat. 2018 Mar;28(3):197-210. DMT3AL5 RU https://www.ncbi.nlm.nih.gov/pubmed/29338548 DMTA3D8 DI DMTA3D8 DMTA3D8 DN PMID29338548-Compound-23 DMTA3D8 MI TTHJTF7 DMTA3D8 MN Glycine transporter GlyT-1 (SLC6A9) DMTA3D8 MT DTT DMTA3D8 MA Inhibitor DMTA3D8 RN Glycine transporter-1 inhibitors: a patent review (2011-2016).Expert Opin Ther Pat. 2018 Mar;28(3):197-210. DMTA3D8 RU https://www.ncbi.nlm.nih.gov/pubmed/29338548 DMWRGOX DI DMWRGOX DMWRGOX DN PMID29338548-Compound-24 DMWRGOX MI TTHJTF7 DMWRGOX MN Glycine transporter GlyT-1 (SLC6A9) DMWRGOX MT DTT DMWRGOX MA Inhibitor DMWRGOX RN Glycine transporter-1 inhibitors: a patent review (2011-2016).Expert Opin Ther Pat. 2018 Mar;28(3):197-210. DMWRGOX RU https://www.ncbi.nlm.nih.gov/pubmed/29338548 DM83LWC DI DM83LWC DM83LWC DN PMID29338548-Compound-25 DM83LWC MI TTHJTF7 DM83LWC MN Glycine transporter GlyT-1 (SLC6A9) DM83LWC MT DTT DM83LWC MA Inhibitor DM83LWC RN Glycine transporter-1 inhibitors: a patent review (2011-2016).Expert Opin Ther Pat. 2018 Mar;28(3):197-210. DM83LWC RU https://www.ncbi.nlm.nih.gov/pubmed/29338548 DMT2D5H DI DMT2D5H DMT2D5H DN PMID29338548-Compound-26 DMT2D5H MI TTHJTF7 DMT2D5H MN Glycine transporter GlyT-1 (SLC6A9) DMT2D5H MT DTT DMT2D5H MA Inhibitor DMT2D5H RN Glycine transporter-1 inhibitors: a patent review (2011-2016).Expert Opin Ther Pat. 2018 Mar;28(3):197-210. DMT2D5H RU https://www.ncbi.nlm.nih.gov/pubmed/29338548 DMNW37Y DI DMNW37Y DMNW37Y DN PMID29338548-Compound-27 DMNW37Y MI TTHJTF7 DMNW37Y MN Glycine transporter GlyT-1 (SLC6A9) DMNW37Y MT DTT DMNW37Y MA Inhibitor DMNW37Y RN Glycine transporter-1 inhibitors: a patent review (2011-2016).Expert Opin Ther Pat. 2018 Mar;28(3):197-210. DMNW37Y RU https://www.ncbi.nlm.nih.gov/pubmed/29338548 DMNBT3K DI DMNBT3K DMNBT3K DN PMID29338548-Compound-28 DMNBT3K MI TTHJTF7 DMNBT3K MN Glycine transporter GlyT-1 (SLC6A9) DMNBT3K MT DTT DMNBT3K MA Inhibitor DMNBT3K RN Glycine transporter-1 inhibitors: a patent review (2011-2016).Expert Opin Ther Pat. 2018 Mar;28(3):197-210. DMNBT3K RU https://www.ncbi.nlm.nih.gov/pubmed/29338548 DMUGC53 DI DMUGC53 DMUGC53 DN PMID29338548-Compound-29 DMUGC53 MI TTHJTF7 DMUGC53 MN Glycine transporter GlyT-1 (SLC6A9) DMUGC53 MT DTT DMUGC53 MA Inhibitor DMUGC53 RN Glycine transporter-1 inhibitors: a patent review (2011-2016).Expert Opin Ther Pat. 2018 Mar;28(3):197-210. DMUGC53 RU https://www.ncbi.nlm.nih.gov/pubmed/29338548 DM8JK2D DI DM8JK2D DM8JK2D DN PMID29338548-Compound-30 DM8JK2D MI TTHJTF7 DM8JK2D MN Glycine transporter GlyT-1 (SLC6A9) DM8JK2D MT DTT DM8JK2D MA Inhibitor DM8JK2D RN Glycine transporter-1 inhibitors: a patent review (2011-2016).Expert Opin Ther Pat. 2018 Mar;28(3):197-210. DM8JK2D RU https://www.ncbi.nlm.nih.gov/pubmed/29338548 DMWMPE2 DI DMWMPE2 DMWMPE2 DN PMID29338548-Compound-31 DMWMPE2 MI TTHJTF7 DMWMPE2 MN Glycine transporter GlyT-1 (SLC6A9) DMWMPE2 MT DTT DMWMPE2 MA Inhibitor DMWMPE2 RN Glycine transporter-1 inhibitors: a patent review (2011-2016).Expert Opin Ther Pat. 2018 Mar;28(3):197-210. DMWMPE2 RU https://www.ncbi.nlm.nih.gov/pubmed/29338548 DM4Q5SW DI DM4Q5SW DM4Q5SW DN PMID29338548-Compound-33 DM4Q5SW MI TTHJTF7 DM4Q5SW MN Glycine transporter GlyT-1 (SLC6A9) DM4Q5SW MT DTT DM4Q5SW MA Inhibitor DM4Q5SW RN Glycine transporter-1 inhibitors: a patent review (2011-2016).Expert Opin Ther Pat. 2018 Mar;28(3):197-210. DM4Q5SW RU https://www.ncbi.nlm.nih.gov/pubmed/29338548 DM839NQ DI DM839NQ DM839NQ DN PMID29338548-Compound-34 DM839NQ MI TTHJTF7 DM839NQ MN Glycine transporter GlyT-1 (SLC6A9) DM839NQ MT DTT DM839NQ MA Inhibitor DM839NQ RN Glycine transporter-1 inhibitors: a patent review (2011-2016).Expert Opin Ther Pat. 2018 Mar;28(3):197-210. DM839NQ RU https://www.ncbi.nlm.nih.gov/pubmed/29338548 DMG675B DI DMG675B DMG675B DN PMID29338548-Compound-36 DMG675B MI TTHJTF7 DMG675B MN Glycine transporter GlyT-1 (SLC6A9) DMG675B MT DTT DMG675B MA Inhibitor DMG675B RN Glycine transporter-1 inhibitors: a patent review (2011-2016).Expert Opin Ther Pat. 2018 Mar;28(3):197-210. DMG675B RU https://www.ncbi.nlm.nih.gov/pubmed/29338548 DMAM0US DI DMAM0US DMAM0US DN PMID29338548-Compound-37 DMAM0US MI TTHJTF7 DMAM0US MN Glycine transporter GlyT-1 (SLC6A9) DMAM0US MT DTT DMAM0US MA Inhibitor DMAM0US RN Glycine transporter-1 inhibitors: a patent review (2011-2016).Expert Opin Ther Pat. 2018 Mar;28(3):197-210. DMAM0US RU https://www.ncbi.nlm.nih.gov/pubmed/29338548 DM6BKQ8 DI DM6BKQ8 DM6BKQ8 DN PMID29338548-Compound-38 DM6BKQ8 MI TTHJTF7 DM6BKQ8 MN Glycine transporter GlyT-1 (SLC6A9) DM6BKQ8 MT DTT DM6BKQ8 MA Inhibitor DM6BKQ8 RN Glycine transporter-1 inhibitors: a patent review (2011-2016).Expert Opin Ther Pat. 2018 Mar;28(3):197-210. DM6BKQ8 RU https://www.ncbi.nlm.nih.gov/pubmed/29338548 DM69Y7R DI DM69Y7R DM69Y7R DN PMID29338548-Compound-39 DM69Y7R MI TTHJTF7 DM69Y7R MN Glycine transporter GlyT-1 (SLC6A9) DM69Y7R MT DTT DM69Y7R MA Inhibitor DM69Y7R RN Glycine transporter-1 inhibitors: a patent review (2011-2016).Expert Opin Ther Pat. 2018 Mar;28(3):197-210. DM69Y7R RU https://www.ncbi.nlm.nih.gov/pubmed/29338548 DMLAHC1 DI DMLAHC1 DMLAHC1 DN PMID29338548-Compound-40 DMLAHC1 MI TTHJTF7 DMLAHC1 MN Glycine transporter GlyT-1 (SLC6A9) DMLAHC1 MT DTT DMLAHC1 MA Inhibitor DMLAHC1 RN Glycine transporter-1 inhibitors: a patent review (2011-2016).Expert Opin Ther Pat. 2018 Mar;28(3):197-210. DMLAHC1 RU https://www.ncbi.nlm.nih.gov/pubmed/29338548 DM2L7ES DI DM2L7ES DM2L7ES DN PMID29338548-Compound-41 DM2L7ES MI TTHJTF7 DM2L7ES MN Glycine transporter GlyT-1 (SLC6A9) DM2L7ES MT DTT DM2L7ES MA Inhibitor DM2L7ES RN Glycine transporter-1 inhibitors: a patent review (2011-2016).Expert Opin Ther Pat. 2018 Mar;28(3):197-210. DM2L7ES RU https://www.ncbi.nlm.nih.gov/pubmed/29338548 DMJYQLC DI DMJYQLC DMJYQLC DN PMID29338548-Compound-44 DMJYQLC MI TTHJTF7 DMJYQLC MN Glycine transporter GlyT-1 (SLC6A9) DMJYQLC MT DTT DMJYQLC MA Inhibitor DMJYQLC RN Glycine transporter-1 inhibitors: a patent review (2011-2016).Expert Opin Ther Pat. 2018 Mar;28(3):197-210. DMJYQLC RU https://www.ncbi.nlm.nih.gov/pubmed/29338548 DMO4JYK DI DMO4JYK DMO4JYK DN PMID29338548-Compound-45 DMO4JYK MI TTHJTF7 DMO4JYK MN Glycine transporter GlyT-1 (SLC6A9) DMO4JYK MT DTT DMO4JYK MA Inhibitor DMO4JYK RN Glycine transporter-1 inhibitors: a patent review (2011-2016).Expert Opin Ther Pat. 2018 Mar;28(3):197-210. DMO4JYK RU https://www.ncbi.nlm.nih.gov/pubmed/29338548 DMRKIA1 DI DMRKIA1 DMRKIA1 DN PMID29338548-Compound-46 DMRKIA1 MI TTHJTF7 DMRKIA1 MN Glycine transporter GlyT-1 (SLC6A9) DMRKIA1 MT DTT DMRKIA1 MA Inhibitor DMRKIA1 RN Glycine transporter-1 inhibitors: a patent review (2011-2016).Expert Opin Ther Pat. 2018 Mar;28(3):197-210. DMRKIA1 RU https://www.ncbi.nlm.nih.gov/pubmed/29338548 DMHBOK6 DI DMHBOK6 DMHBOK6 DN PMID29338548-Compound-47 DMHBOK6 MI TTHJTF7 DMHBOK6 MN Glycine transporter GlyT-1 (SLC6A9) DMHBOK6 MT DTT DMHBOK6 MA Inhibitor DMHBOK6 RN Glycine transporter-1 inhibitors: a patent review (2011-2016).Expert Opin Ther Pat. 2018 Mar;28(3):197-210. DMHBOK6 RU https://www.ncbi.nlm.nih.gov/pubmed/29338548 DMDRJHO DI DMDRJHO DMDRJHO DN PMID29338548-Compound-48 DMDRJHO MI TTHJTF7 DMDRJHO MN Glycine transporter GlyT-1 (SLC6A9) DMDRJHO MT DTT DMDRJHO MA Inhibitor DMDRJHO RN Glycine transporter-1 inhibitors: a patent review (2011-2016).Expert Opin Ther Pat. 2018 Mar;28(3):197-210. DMDRJHO RU https://www.ncbi.nlm.nih.gov/pubmed/29338548 DM1NJ3U DI DM1NJ3U DM1NJ3U DN PMID29338548-Compound-49 DM1NJ3U MI TTHJTF7 DM1NJ3U MN Glycine transporter GlyT-1 (SLC6A9) DM1NJ3U MT DTT DM1NJ3U MA Inhibitor DM1NJ3U RN Glycine transporter-1 inhibitors: a patent review (2011-2016).Expert Opin Ther Pat. 2018 Mar;28(3):197-210. DM1NJ3U RU https://www.ncbi.nlm.nih.gov/pubmed/29338548 DM7EW5U DI DM7EW5U DM7EW5U DN PMID29473428-Compound-10 DM7EW5U MI TTZJYKH DM7EW5U MN Indoleamine 2,3-dioxygenase 1 (IDO1) DM7EW5U MT DTT DM7EW5U RN A patent review of IDO1 inhibitors for cancer.Expert Opin Ther Pat. 2018 Apr;28(4):317-330. DM7EW5U RU https://www.ncbi.nlm.nih.gov/pubmed/29473428 DM5MXFK DI DM5MXFK DM5MXFK DN PMID29473428-Compound-11 DM5MXFK MI TTZJYKH DM5MXFK MN Indoleamine 2,3-dioxygenase 1 (IDO1) DM5MXFK MT DTT DM5MXFK RN A patent review of IDO1 inhibitors for cancer.Expert Opin Ther Pat. 2018 Apr;28(4):317-330. DM5MXFK RU https://www.ncbi.nlm.nih.gov/pubmed/29473428 DMCB0D6 DI DMCB0D6 DMCB0D6 DN PMID29473428-Compound-14 DMCB0D6 MI TTZJYKH DMCB0D6 MN Indoleamine 2,3-dioxygenase 1 (IDO1) DMCB0D6 MT DTT DMCB0D6 MA Inhibitor DMCB0D6 RN A patent review of IDO1 inhibitors for cancer.Expert Opin Ther Pat. 2018 Apr;28(4):317-330. DMCB0D6 RU https://www.ncbi.nlm.nih.gov/pubmed/29473428 DM571JP DI DM571JP DM571JP DN PMID29473428-Compound-15 DM571JP MI TTZJYKH DM571JP MN Indoleamine 2,3-dioxygenase 1 (IDO1) DM571JP MT DTT DM571JP MA Inhibitor DM571JP RN A patent review of IDO1 inhibitors for cancer.Expert Opin Ther Pat. 2018 Apr;28(4):317-330. DM571JP RU https://www.ncbi.nlm.nih.gov/pubmed/29473428 DM21QCE DI DM21QCE DM21QCE DN PMID29473428-Compound-16 DM21QCE MI TTZJYKH DM21QCE MN Indoleamine 2,3-dioxygenase 1 (IDO1) DM21QCE MT DTT DM21QCE RN A patent review of IDO1 inhibitors for cancer.Expert Opin Ther Pat. 2018 Apr;28(4):317-330. DM21QCE RU https://www.ncbi.nlm.nih.gov/pubmed/29473428 DMI04GC DI DMI04GC DMI04GC DN PMID29473428-Compound-17 DMI04GC MI TTZJYKH DMI04GC MN Indoleamine 2,3-dioxygenase 1 (IDO1) DMI04GC MT DTT DMI04GC RN A patent review of IDO1 inhibitors for cancer.Expert Opin Ther Pat. 2018 Apr;28(4):317-330. DMI04GC RU https://www.ncbi.nlm.nih.gov/pubmed/29473428 DMZGNWO DI DMZGNWO DMZGNWO DN PMID29473428-Compound-21 DMZGNWO MI TTZJYKH DMZGNWO MN Indoleamine 2,3-dioxygenase 1 (IDO1) DMZGNWO MT DTT DMZGNWO MA Inhibitor DMZGNWO RN A patent review of IDO1 inhibitors for cancer.Expert Opin Ther Pat. 2018 Apr;28(4):317-330. DMZGNWO RU https://www.ncbi.nlm.nih.gov/pubmed/29473428 DMCNSZD DI DMCNSZD DMCNSZD DN PMID29473428-Compound-22 DMCNSZD MI TTZJYKH DMCNSZD MN Indoleamine 2,3-dioxygenase 1 (IDO1) DMCNSZD MT DTT DMCNSZD MA Inhibitor DMCNSZD RN A patent review of IDO1 inhibitors for cancer.Expert Opin Ther Pat. 2018 Apr;28(4):317-330. DMCNSZD RU https://www.ncbi.nlm.nih.gov/pubmed/29473428 DMBMTUV DI DMBMTUV DMBMTUV DN PMID29473428-Compound-29 DMBMTUV MI TTZJYKH DMBMTUV MN Indoleamine 2,3-dioxygenase 1 (IDO1) DMBMTUV MT DTT DMBMTUV MA Inhibitor DMBMTUV RN A patent review of IDO1 inhibitors for cancer.Expert Opin Ther Pat. 2018 Apr;28(4):317-330. DMBMTUV RU https://www.ncbi.nlm.nih.gov/pubmed/29473428 DMZA3FL DI DMZA3FL DMZA3FL DN PMID29473428-Compound-33 DMZA3FL MI TTZJYKH DMZA3FL MN Indoleamine 2,3-dioxygenase 1 (IDO1) DMZA3FL MT DTT DMZA3FL MA Inhibitor DMZA3FL RN A patent review of IDO1 inhibitors for cancer.Expert Opin Ther Pat. 2018 Apr;28(4):317-330. DMZA3FL RU https://www.ncbi.nlm.nih.gov/pubmed/29473428 DM7BRPI DI DM7BRPI DM7BRPI DN PMID29473428-Compound-34 DM7BRPI MI TTZJYKH DM7BRPI MN Indoleamine 2,3-dioxygenase 1 (IDO1) DM7BRPI MT DTT DM7BRPI MA Inhibitor DM7BRPI RN A patent review of IDO1 inhibitors for cancer.Expert Opin Ther Pat. 2018 Apr;28(4):317-330. DM7BRPI RU https://www.ncbi.nlm.nih.gov/pubmed/29473428 DMKRUPW DI DMKRUPW DMKRUPW DN PMID29473428-Compound-39 DMKRUPW MI TTZJYKH DMKRUPW MN Indoleamine 2,3-dioxygenase 1 (IDO1) DMKRUPW MT DTT DMKRUPW MA Antagonist DMKRUPW RN A patent review of IDO1 inhibitors for cancer.Expert Opin Ther Pat. 2018 Apr;28(4):317-330. DMKRUPW RU https://www.ncbi.nlm.nih.gov/pubmed/29473428 DM9KVOD DI DM9KVOD DM9KVOD DN PMID29473428-Compound-4 DM9KVOD MI TTZJYKH DM9KVOD MN Indoleamine 2,3-dioxygenase 1 (IDO1) DM9KVOD MT DTT DM9KVOD RN A patent review of IDO1 inhibitors for cancer.Expert Opin Ther Pat. 2018 Apr;28(4):317-330. DM9KVOD RU https://www.ncbi.nlm.nih.gov/pubmed/29473428 DM4AOIR DI DM4AOIR DM4AOIR DN PMID29473428-Compound-41 DM4AOIR MI TTZJYKH DM4AOIR MN Indoleamine 2,3-dioxygenase 1 (IDO1) DM4AOIR MT DTT DM4AOIR MA Antagonist DM4AOIR RN A patent review of IDO1 inhibitors for cancer.Expert Opin Ther Pat. 2018 Apr;28(4):317-330. DM4AOIR RU https://www.ncbi.nlm.nih.gov/pubmed/29473428 DMQ8EYV DI DMQ8EYV DMQ8EYV DN PMID29473428-Compound-43 DMQ8EYV MI TTZJYKH DMQ8EYV MN Indoleamine 2,3-dioxygenase 1 (IDO1) DMQ8EYV MT DTT DMQ8EYV MA Inhibitor DMQ8EYV RN A patent review of IDO1 inhibitors for cancer.Expert Opin Ther Pat. 2018 Apr;28(4):317-330. DMQ8EYV RU https://www.ncbi.nlm.nih.gov/pubmed/29473428 DMCLJ0M DI DMCLJ0M DMCLJ0M DN PMID29473428-Compound-47 DMCLJ0M MI TTZJYKH DMCLJ0M MN Indoleamine 2,3-dioxygenase 1 (IDO1) DMCLJ0M MT DTT DMCLJ0M MA Inhibitor DMCLJ0M RN A patent review of IDO1 inhibitors for cancer.Expert Opin Ther Pat. 2018 Apr;28(4):317-330. DMCLJ0M RU https://www.ncbi.nlm.nih.gov/pubmed/29473428 DMAYT2E DI DMAYT2E DMAYT2E DN PMID29473428-Compound-48 DMAYT2E MI TTZJYKH DMAYT2E MN Indoleamine 2,3-dioxygenase 1 (IDO1) DMAYT2E MT DTT DMAYT2E MA Inhibitor DMAYT2E RN A patent review of IDO1 inhibitors for cancer.Expert Opin Ther Pat. 2018 Apr;28(4):317-330. DMAYT2E RU https://www.ncbi.nlm.nih.gov/pubmed/29473428 DMXUVDH DI DMXUVDH DMXUVDH DN PMID29473428-Compound-50 DMXUVDH MI TTZJYKH DMXUVDH MN Indoleamine 2,3-dioxygenase 1 (IDO1) DMXUVDH MT DTT DMXUVDH MA Inhibitor DMXUVDH RN A patent review of IDO1 inhibitors for cancer.Expert Opin Ther Pat. 2018 Apr;28(4):317-330. DMXUVDH RU https://www.ncbi.nlm.nih.gov/pubmed/29473428 DMSXKP6 DI DMSXKP6 DMSXKP6 DN PMID29473428-Compound-52 DMSXKP6 MI TTZJYKH DMSXKP6 MN Indoleamine 2,3-dioxygenase 1 (IDO1) DMSXKP6 MT DTT DMSXKP6 MA Inhibitor DMSXKP6 RN A patent review of IDO1 inhibitors for cancer.Expert Opin Ther Pat. 2018 Apr;28(4):317-330. DMSXKP6 RU https://www.ncbi.nlm.nih.gov/pubmed/29473428 DMOASLQ DI DMOASLQ DMOASLQ DN PMID29473428-Compound-53 DMOASLQ MI TTZJYKH DMOASLQ MN Indoleamine 2,3-dioxygenase 1 (IDO1) DMOASLQ MT DTT DMOASLQ MA Inhibitor DMOASLQ RN A patent review of IDO1 inhibitors for cancer.Expert Opin Ther Pat. 2018 Apr;28(4):317-330. DMOASLQ RU https://www.ncbi.nlm.nih.gov/pubmed/29473428 DMKIS26 DI DMKIS26 DMKIS26 DN PMID29473428-Compound-54 DMKIS26 MI TTZJYKH DMKIS26 MN Indoleamine 2,3-dioxygenase 1 (IDO1) DMKIS26 MT DTT DMKIS26 MA Inhibitor DMKIS26 RN A patent review of IDO1 inhibitors for cancer.Expert Opin Ther Pat. 2018 Apr;28(4):317-330. DMKIS26 RU https://www.ncbi.nlm.nih.gov/pubmed/29473428 DMVP7DL DI DMVP7DL DMVP7DL DN PMID29473428-Compound-58 DMVP7DL MI TTZJYKH DMVP7DL MN Indoleamine 2,3-dioxygenase 1 (IDO1) DMVP7DL MT DTT DMVP7DL MA Inhibitor DMVP7DL RN A patent review of IDO1 inhibitors for cancer.Expert Opin Ther Pat. 2018 Apr;28(4):317-330. DMVP7DL RU https://www.ncbi.nlm.nih.gov/pubmed/29473428 DMJYUN2 DI DMJYUN2 DMJYUN2 DN PMID29473428-Compound-59 DMJYUN2 MI TTZJYKH DMJYUN2 MN Indoleamine 2,3-dioxygenase 1 (IDO1) DMJYUN2 MT DTT DMJYUN2 MA Inhibitor DMJYUN2 RN A patent review of IDO1 inhibitors for cancer.Expert Opin Ther Pat. 2018 Apr;28(4):317-330. DMJYUN2 RU https://www.ncbi.nlm.nih.gov/pubmed/29473428 DMOVPWD DI DMOVPWD DMOVPWD DN PMID29473428-Compound-6 DMOVPWD MI TTZJYKH DMOVPWD MN Indoleamine 2,3-dioxygenase 1 (IDO1) DMOVPWD MT DTT DMOVPWD RN A patent review of IDO1 inhibitors for cancer.Expert Opin Ther Pat. 2018 Apr;28(4):317-330. DMOVPWD RU https://www.ncbi.nlm.nih.gov/pubmed/29473428 DMRKWPQ DI DMRKWPQ DMRKWPQ DN PMID29473428-Compound-60 DMRKWPQ MI TTZJYKH DMRKWPQ MN Indoleamine 2,3-dioxygenase 1 (IDO1) DMRKWPQ MT DTT DMRKWPQ MA Inhibitor DMRKWPQ RN A patent review of IDO1 inhibitors for cancer.Expert Opin Ther Pat. 2018 Apr;28(4):317-330. DMRKWPQ RU https://www.ncbi.nlm.nih.gov/pubmed/29473428 DMMV5KI DI DMMV5KI DMMV5KI DN PMID29473428-Compound-70 DMMV5KI MI TTZJYKH DMMV5KI MN Indoleamine 2,3-dioxygenase 1 (IDO1) DMMV5KI MT DTT DMMV5KI MA Inhibitor DMMV5KI RN A patent review of IDO1 inhibitors for cancer.Expert Opin Ther Pat. 2018 Apr;28(4):317-330. DMMV5KI RU https://www.ncbi.nlm.nih.gov/pubmed/29473428 DML5G6D DI DML5G6D DML5G6D DN PMID29473428-Compound-71 DML5G6D MI TTZJYKH DML5G6D MN Indoleamine 2,3-dioxygenase 1 (IDO1) DML5G6D MT DTT DML5G6D MA Inhibitor DML5G6D RN A patent review of IDO1 inhibitors for cancer.Expert Opin Ther Pat. 2018 Apr;28(4):317-330. DML5G6D RU https://www.ncbi.nlm.nih.gov/pubmed/29473428 DMJOBUZ DI DMJOBUZ DMJOBUZ DN PMID29473428-Compound-72 DMJOBUZ MI TTZJYKH DMJOBUZ MN Indoleamine 2,3-dioxygenase 1 (IDO1) DMJOBUZ MT DTT DMJOBUZ MA Inhibitor DMJOBUZ RN A patent review of IDO1 inhibitors for cancer.Expert Opin Ther Pat. 2018 Apr;28(4):317-330. DMJOBUZ RU https://www.ncbi.nlm.nih.gov/pubmed/29473428 DM8PZ46 DI DM8PZ46 DM8PZ46 DN PMID29473428-Compound-76 DM8PZ46 MI TTZJYKH DM8PZ46 MN Indoleamine 2,3-dioxygenase 1 (IDO1) DM8PZ46 MT DTT DM8PZ46 MA Inhibitor DM8PZ46 RN A patent review of IDO1 inhibitors for cancer.Expert Opin Ther Pat. 2018 Apr;28(4):317-330. DM8PZ46 RU https://www.ncbi.nlm.nih.gov/pubmed/29473428 DM8PZ46 DI DM8PZ46 DM8PZ46 DN PMID29473428-Compound-76 DM8PZ46 MI TTXNCBV DM8PZ46 MN Tryptophan 2,3-dioxygenase (TDO) DM8PZ46 MT DTT DM8PZ46 MA Inhibitor DM8PZ46 RN A patent review of IDO1 inhibitors for cancer.Expert Opin Ther Pat. 2018 Apr;28(4):317-330. DM8PZ46 RU https://www.ncbi.nlm.nih.gov/pubmed/29473428 DM8VBU2 DI DM8VBU2 DM8VBU2 DN PMID29473428-Compound-80 DM8VBU2 MI TTZJYKH DM8VBU2 MN Indoleamine 2,3-dioxygenase 1 (IDO1) DM8VBU2 MT DTT DM8VBU2 MA Inhibitor DM8VBU2 RN A patent review of IDO1 inhibitors for cancer.Expert Opin Ther Pat. 2018 Apr;28(4):317-330. DM8VBU2 RU https://www.ncbi.nlm.nih.gov/pubmed/29473428 DMDKT9X DI DMDKT9X DMDKT9X DN PMID29649907-Compound-1 DMDKT9X MI TTS4UGC DMDKT9X MN Farnesoid X-activated receptor (FXR) DMDKT9X MT DTT DMDKT9X MA Agonist DMDKT9X RN Farnesoid X receptor modulators 2014-present: a patent review.Expert Opin Ther Pat. 2018 May;28(5):351-364. DMDKT9X RU https://www.ncbi.nlm.nih.gov/pubmed/29649907 DMNE9AX DI DMNE9AX DMNE9AX DN PMID29649907-Compound-10 DMNE9AX MI TTS4UGC DMNE9AX MN Farnesoid X-activated receptor (FXR) DMNE9AX MT DTT DMNE9AX MA Agonist DMNE9AX RN Farnesoid X receptor modulators 2014-present: a patent review.Expert Opin Ther Pat. 2018 May;28(5):351-364. DMNE9AX RU https://www.ncbi.nlm.nih.gov/pubmed/29649907 DMSC9MH DI DMSC9MH DMSC9MH DN PMID29649907-Compound-11 DMSC9MH MI TTS4UGC DMSC9MH MN Farnesoid X-activated receptor (FXR) DMSC9MH MT DTT DMSC9MH MA Agonist DMSC9MH RN Farnesoid X receptor modulators 2014-present: a patent review.Expert Opin Ther Pat. 2018 May;28(5):351-364. DMSC9MH RU https://www.ncbi.nlm.nih.gov/pubmed/29649907 DMBHT2E DI DMBHT2E DMBHT2E DN PMID29649907-Compound-12 DMBHT2E MI TTS4UGC DMBHT2E MN Farnesoid X-activated receptor (FXR) DMBHT2E MT DTT DMBHT2E MA Agonist DMBHT2E RN Farnesoid X receptor modulators 2014-present: a patent review.Expert Opin Ther Pat. 2018 May;28(5):351-364. DMBHT2E RU https://www.ncbi.nlm.nih.gov/pubmed/29649907 DMLBQUS DI DMLBQUS DMLBQUS DN PMID29649907-Compound-13 DMLBQUS MI TTS4UGC DMLBQUS MN Farnesoid X-activated receptor (FXR) DMLBQUS MT DTT DMLBQUS MA Agonist DMLBQUS RN Farnesoid X receptor modulators 2014-present: a patent review.Expert Opin Ther Pat. 2018 May;28(5):351-364. DMLBQUS RU https://www.ncbi.nlm.nih.gov/pubmed/29649907 DMQAV30 DI DMQAV30 DMQAV30 DN PMID29649907-Compound-14 DMQAV30 MI TTS4UGC DMQAV30 MN Farnesoid X-activated receptor (FXR) DMQAV30 MT DTT DMQAV30 MA Agonist DMQAV30 RN Farnesoid X receptor modulators 2014-present: a patent review.Expert Opin Ther Pat. 2018 May;28(5):351-364. DMQAV30 RU https://www.ncbi.nlm.nih.gov/pubmed/29649907 DMMIKFU DI DMMIKFU DMMIKFU DN PMID29649907-Compound-15 DMMIKFU MI TTS4UGC DMMIKFU MN Farnesoid X-activated receptor (FXR) DMMIKFU MT DTT DMMIKFU MA Agonist DMMIKFU RN Farnesoid X receptor modulators 2014-present: a patent review.Expert Opin Ther Pat. 2018 May;28(5):351-364. DMMIKFU RU https://www.ncbi.nlm.nih.gov/pubmed/29649907 DMBVOZK DI DMBVOZK DMBVOZK DN PMID29649907-Compound-18 DMBVOZK MI TTS4UGC DMBVOZK MN Farnesoid X-activated receptor (FXR) DMBVOZK MT DTT DMBVOZK MA Agonist DMBVOZK RN Farnesoid X receptor modulators 2014-present: a patent review.Expert Opin Ther Pat. 2018 May;28(5):351-364. DMBVOZK RU https://www.ncbi.nlm.nih.gov/pubmed/29649907 DMFL38V DI DMFL38V DMFL38V DN PMID29649907-Compound-19 DMFL38V MI TTS4UGC DMFL38V MN Farnesoid X-activated receptor (FXR) DMFL38V MT DTT DMFL38V MA Agonist DMFL38V RN Farnesoid X receptor modulators 2014-present: a patent review.Expert Opin Ther Pat. 2018 May;28(5):351-364. DMFL38V RU https://www.ncbi.nlm.nih.gov/pubmed/29649907 DMM4TBH DI DMM4TBH DMM4TBH DN PMID29649907-Compound-2 DMM4TBH MI TTS4UGC DMM4TBH MN Farnesoid X-activated receptor (FXR) DMM4TBH MT DTT DMM4TBH MA Agonist DMM4TBH RN Farnesoid X receptor modulators 2014-present: a patent review.Expert Opin Ther Pat. 2018 May;28(5):351-364. DMM4TBH RU https://www.ncbi.nlm.nih.gov/pubmed/29649907 DMGNW34 DI DMGNW34 DMGNW34 DN PMID29649907-Compound-20 DMGNW34 MI TTS4UGC DMGNW34 MN Farnesoid X-activated receptor (FXR) DMGNW34 MT DTT DMGNW34 MA Agonist DMGNW34 RN Farnesoid X receptor modulators 2014-present: a patent review.Expert Opin Ther Pat. 2018 May;28(5):351-364. DMGNW34 RU https://www.ncbi.nlm.nih.gov/pubmed/29649907 DMES0UY DI DMES0UY DMES0UY DN PMID29649907-Compound-21 DMES0UY MI TTS4UGC DMES0UY MN Farnesoid X-activated receptor (FXR) DMES0UY MT DTT DMES0UY MA Agonist DMES0UY RN Farnesoid X receptor modulators 2014-present: a patent review.Expert Opin Ther Pat. 2018 May;28(5):351-364. DMES0UY RU https://www.ncbi.nlm.nih.gov/pubmed/29649907 DMXW108 DI DMXW108 DMXW108 DN PMID29649907-Compound-22 DMXW108 MI TTS4UGC DMXW108 MN Farnesoid X-activated receptor (FXR) DMXW108 MT DTT DMXW108 MA Agonist DMXW108 RN Farnesoid X receptor modulators 2014-present: a patent review.Expert Opin Ther Pat. 2018 May;28(5):351-364. DMXW108 RU https://www.ncbi.nlm.nih.gov/pubmed/29649907 DMW7T45 DI DMW7T45 DMW7T45 DN PMID29649907-Compound-23 DMW7T45 MI TTS4UGC DMW7T45 MN Farnesoid X-activated receptor (FXR) DMW7T45 MT DTT DMW7T45 MA Agonist DMW7T45 RN Farnesoid X receptor modulators 2014-present: a patent review.Expert Opin Ther Pat. 2018 May;28(5):351-364. DMW7T45 RU https://www.ncbi.nlm.nih.gov/pubmed/29649907 DMUHNS7 DI DMUHNS7 DMUHNS7 DN PMID29649907-Compound-24 DMUHNS7 MI TTS4UGC DMUHNS7 MN Farnesoid X-activated receptor (FXR) DMUHNS7 MT DTT DMUHNS7 MA Agonist DMUHNS7 RN Farnesoid X receptor modulators 2014-present: a patent review.Expert Opin Ther Pat. 2018 May;28(5):351-364. DMUHNS7 RU https://www.ncbi.nlm.nih.gov/pubmed/29649907 DMALOEW DI DMALOEW DMALOEW DN PMID29649907-Compound-25 DMALOEW MI TTS4UGC DMALOEW MN Farnesoid X-activated receptor (FXR) DMALOEW MT DTT DMALOEW MA Agonist DMALOEW RN Farnesoid X receptor modulators 2014-present: a patent review.Expert Opin Ther Pat. 2018 May;28(5):351-364. DMALOEW RU https://www.ncbi.nlm.nih.gov/pubmed/29649907 DM6O78C DI DM6O78C DM6O78C DN PMID29649907-Compound-26 DM6O78C MI TTS4UGC DM6O78C MN Farnesoid X-activated receptor (FXR) DM6O78C MT DTT DM6O78C MA Agonist DM6O78C RN Farnesoid X receptor modulators 2014-present: a patent review.Expert Opin Ther Pat. 2018 May;28(5):351-364. DM6O78C RU https://www.ncbi.nlm.nih.gov/pubmed/29649907 DMQDGZL DI DMQDGZL DMQDGZL DN PMID29649907-Compound-27 DMQDGZL MI TTS4UGC DMQDGZL MN Farnesoid X-activated receptor (FXR) DMQDGZL MT DTT DMQDGZL MA Agonist DMQDGZL RN Farnesoid X receptor modulators 2014-present: a patent review.Expert Opin Ther Pat. 2018 May;28(5):351-364. DMQDGZL RU https://www.ncbi.nlm.nih.gov/pubmed/29649907 DMYMKZC DI DMYMKZC DMYMKZC DN PMID29649907-Compound-28 DMYMKZC MI TTS4UGC DMYMKZC MN Farnesoid X-activated receptor (FXR) DMYMKZC MT DTT DMYMKZC MA Agonist DMYMKZC RN Farnesoid X receptor modulators 2014-present: a patent review.Expert Opin Ther Pat. 2018 May;28(5):351-364. DMYMKZC RU https://www.ncbi.nlm.nih.gov/pubmed/29649907 DMEVZIK DI DMEVZIK DMEVZIK DN PMID29649907-Compound-29 DMEVZIK MI TTS4UGC DMEVZIK MN Farnesoid X-activated receptor (FXR) DMEVZIK MT DTT DMEVZIK MA Agonist DMEVZIK RN Farnesoid X receptor modulators 2014-present: a patent review.Expert Opin Ther Pat. 2018 May;28(5):351-364. DMEVZIK RU https://www.ncbi.nlm.nih.gov/pubmed/29649907 DMPVSG9 DI DMPVSG9 DMPVSG9 DN PMID29649907-Compound-3 DMPVSG9 MI TTS4UGC DMPVSG9 MN Farnesoid X-activated receptor (FXR) DMPVSG9 MT DTT DMPVSG9 MA Agonist DMPVSG9 RN Farnesoid X receptor modulators 2014-present: a patent review.Expert Opin Ther Pat. 2018 May;28(5):351-364. DMPVSG9 RU https://www.ncbi.nlm.nih.gov/pubmed/29649907 DM0SY7Q DI DM0SY7Q DM0SY7Q DN PMID29649907-Compound-30 DM0SY7Q MI TTS4UGC DM0SY7Q MN Farnesoid X-activated receptor (FXR) DM0SY7Q MT DTT DM0SY7Q MA Agonist DM0SY7Q RN Farnesoid X receptor modulators 2014-present: a patent review.Expert Opin Ther Pat. 2018 May;28(5):351-364. DM0SY7Q RU https://www.ncbi.nlm.nih.gov/pubmed/29649907 DME6H8Q DI DME6H8Q DME6H8Q DN PMID29649907-Compound-31 DME6H8Q MI TTS4UGC DME6H8Q MN Farnesoid X-activated receptor (FXR) DME6H8Q MT DTT DME6H8Q MA Agonist DME6H8Q RN Farnesoid X receptor modulators 2014-present: a patent review.Expert Opin Ther Pat. 2018 May;28(5):351-364. DME6H8Q RU https://www.ncbi.nlm.nih.gov/pubmed/29649907 DM7E9HA DI DM7E9HA DM7E9HA DN PMID29649907-Compound-32 DM7E9HA MI TTS4UGC DM7E9HA MN Farnesoid X-activated receptor (FXR) DM7E9HA MT DTT DM7E9HA MA Agonist DM7E9HA RN Farnesoid X receptor modulators 2014-present: a patent review.Expert Opin Ther Pat. 2018 May;28(5):351-364. DM7E9HA RU https://www.ncbi.nlm.nih.gov/pubmed/29649907 DM39HCU DI DM39HCU DM39HCU DN PMID29649907-Compound-33 DM39HCU MI TTS4UGC DM39HCU MN Farnesoid X-activated receptor (FXR) DM39HCU MT DTT DM39HCU MA Agonist DM39HCU RN Farnesoid X receptor modulators 2014-present: a patent review.Expert Opin Ther Pat. 2018 May;28(5):351-364. DM39HCU RU https://www.ncbi.nlm.nih.gov/pubmed/29649907 DMUDKE0 DI DMUDKE0 DMUDKE0 DN PMID29649907-Compound-34 DMUDKE0 MI TTS4UGC DMUDKE0 MN Farnesoid X-activated receptor (FXR) DMUDKE0 MT DTT DMUDKE0 MA Agonist DMUDKE0 RN Farnesoid X receptor modulators 2014-present: a patent review.Expert Opin Ther Pat. 2018 May;28(5):351-364. DMUDKE0 RU https://www.ncbi.nlm.nih.gov/pubmed/29649907 DMSWJPO DI DMSWJPO DMSWJPO DN PMID29649907-Compound-35 DMSWJPO MI TTS4UGC DMSWJPO MN Farnesoid X-activated receptor (FXR) DMSWJPO MT DTT DMSWJPO MA Agonist DMSWJPO RN Farnesoid X receptor modulators 2014-present: a patent review.Expert Opin Ther Pat. 2018 May;28(5):351-364. DMSWJPO RU https://www.ncbi.nlm.nih.gov/pubmed/29649907 DMP5KEW DI DMP5KEW DMP5KEW DN PMID29649907-Compound-36 DMP5KEW MI TTS4UGC DMP5KEW MN Farnesoid X-activated receptor (FXR) DMP5KEW MT DTT DMP5KEW MA Agonist DMP5KEW RN Farnesoid X receptor modulators 2014-present: a patent review.Expert Opin Ther Pat. 2018 May;28(5):351-364. DMP5KEW RU https://www.ncbi.nlm.nih.gov/pubmed/29649907 DM8WKYT DI DM8WKYT DM8WKYT DN PMID29649907-Compound-37 DM8WKYT MI TTS4UGC DM8WKYT MN Farnesoid X-activated receptor (FXR) DM8WKYT MT DTT DM8WKYT MA Agonist DM8WKYT RN Farnesoid X receptor modulators 2014-present: a patent review.Expert Opin Ther Pat. 2018 May;28(5):351-364. DM8WKYT RU https://www.ncbi.nlm.nih.gov/pubmed/29649907 DMMP09F DI DMMP09F DMMP09F DN PMID29649907-Compound-38 DMMP09F MI TTS4UGC DMMP09F MN Farnesoid X-activated receptor (FXR) DMMP09F MT DTT DMMP09F MA Agonist DMMP09F RN Farnesoid X receptor modulators 2014-present: a patent review.Expert Opin Ther Pat. 2018 May;28(5):351-364. DMMP09F RU https://www.ncbi.nlm.nih.gov/pubmed/29649907 DMI3ELU DI DMI3ELU DMI3ELU DN PMID29649907-Compound-39 DMI3ELU MI TTS4UGC DMI3ELU MN Farnesoid X-activated receptor (FXR) DMI3ELU MT DTT DMI3ELU MA Agonist DMI3ELU RN Farnesoid X receptor modulators 2014-present: a patent review.Expert Opin Ther Pat. 2018 May;28(5):351-364. DMI3ELU RU https://www.ncbi.nlm.nih.gov/pubmed/29649907 DMO45VP DI DMO45VP DMO45VP DN PMID29649907-Compound-4 DMO45VP MI TTS4UGC DMO45VP MN Farnesoid X-activated receptor (FXR) DMO45VP MT DTT DMO45VP MA Agonist DMO45VP RN Farnesoid X receptor modulators 2014-present: a patent review.Expert Opin Ther Pat. 2018 May;28(5):351-364. DMO45VP RU https://www.ncbi.nlm.nih.gov/pubmed/29649907 DMS6UD2 DI DMS6UD2 DMS6UD2 DN PMID29649907-Compound-40 DMS6UD2 MI TTS4UGC DMS6UD2 MN Farnesoid X-activated receptor (FXR) DMS6UD2 MT DTT DMS6UD2 MA Agonist DMS6UD2 RN Farnesoid X receptor modulators 2014-present: a patent review.Expert Opin Ther Pat. 2018 May;28(5):351-364. DMS6UD2 RU https://www.ncbi.nlm.nih.gov/pubmed/29649907 DM26IRH DI DM26IRH DM26IRH DN PMID29649907-Compound-41 DM26IRH MI TTS4UGC DM26IRH MN Farnesoid X-activated receptor (FXR) DM26IRH MT DTT DM26IRH MA Agonist DM26IRH RN Farnesoid X receptor modulators 2014-present: a patent review.Expert Opin Ther Pat. 2018 May;28(5):351-364. DM26IRH RU https://www.ncbi.nlm.nih.gov/pubmed/29649907 DMSAD9B DI DMSAD9B DMSAD9B DN PMID29649907-Compound-42 DMSAD9B MI TTS4UGC DMSAD9B MN Farnesoid X-activated receptor (FXR) DMSAD9B MT DTT DMSAD9B MA Agonist DMSAD9B RN Farnesoid X receptor modulators 2014-present: a patent review.Expert Opin Ther Pat. 2018 May;28(5):351-364. DMSAD9B RU https://www.ncbi.nlm.nih.gov/pubmed/29649907 DMBA2S3 DI DMBA2S3 DMBA2S3 DN PMID29649907-Compound-44 DMBA2S3 MI TTS4UGC DMBA2S3 MN Farnesoid X-activated receptor (FXR) DMBA2S3 MT DTT DMBA2S3 MA Antagonist DMBA2S3 RN Farnesoid X receptor modulators 2014-present: a patent review.Expert Opin Ther Pat. 2018 May;28(5):351-364. DMBA2S3 RU https://www.ncbi.nlm.nih.gov/pubmed/29649907 DMDWSIE DI DMDWSIE DMDWSIE DN PMID29649907-Compound-5 DMDWSIE MI TTS4UGC DMDWSIE MN Farnesoid X-activated receptor (FXR) DMDWSIE MT DTT DMDWSIE MA Agonist DMDWSIE RN Farnesoid X receptor modulators 2014-present: a patent review.Expert Opin Ther Pat. 2018 May;28(5):351-364. DMDWSIE RU https://www.ncbi.nlm.nih.gov/pubmed/29649907 DMV2D5M DI DMV2D5M DMV2D5M DN PMID29649907-Compound-8 DMV2D5M MI TTS4UGC DMV2D5M MN Farnesoid X-activated receptor (FXR) DMV2D5M MT DTT DMV2D5M MA Agonist DMV2D5M RN Farnesoid X receptor modulators 2014-present: a patent review.Expert Opin Ther Pat. 2018 May;28(5):351-364. DMV2D5M RU https://www.ncbi.nlm.nih.gov/pubmed/29649907 DMV2D5M DI DMV2D5M DMV2D5M DN PMID29649907-Compound-8 DMV2D5M MI TTSDVTR DMV2D5M MN G-protein coupled bile acid receptor 1 (GPBAR1) DMV2D5M MT DTT DMV2D5M MA Agonist DMV2D5M RN Farnesoid X receptor modulators 2014-present: a patent review.Expert Opin Ther Pat. 2018 May;28(5):351-364. DMV2D5M RU https://www.ncbi.nlm.nih.gov/pubmed/29649907 DMA6H4W DI DMA6H4W DMA6H4W DN PMID29649907-Compound-9 DMA6H4W MI TTS4UGC DMA6H4W MN Farnesoid X-activated receptor (FXR) DMA6H4W MT DTT DMA6H4W MA Agonist DMA6H4W RN Farnesoid X receptor modulators 2014-present: a patent review.Expert Opin Ther Pat. 2018 May;28(5):351-364. DMA6H4W RU https://www.ncbi.nlm.nih.gov/pubmed/29649907 DMA0RI8 DI DMA0RI8 DMA0RI8 DN PMID29649907-Compound-INT767 DMA0RI8 MI TTS4UGC DMA0RI8 MN Farnesoid X-activated receptor (FXR) DMA0RI8 MT DTT DMA0RI8 MA Agonist DMA0RI8 RN Farnesoid X receptor modulators 2014-present: a patent review.Expert Opin Ther Pat. 2018 May;28(5):351-364. DMA0RI8 RU https://www.ncbi.nlm.nih.gov/pubmed/29649907 DMA0RI8 DI DMA0RI8 DMA0RI8 DN PMID29649907-Compound-INT767 DMA0RI8 MI TTSDVTR DMA0RI8 MN G-protein coupled bile acid receptor 1 (GPBAR1) DMA0RI8 MT DTT DMA0RI8 MA Agonist DMA0RI8 RN Farnesoid X receptor modulators 2014-present: a patent review.Expert Opin Ther Pat. 2018 May;28(5):351-364. DMA0RI8 RU https://www.ncbi.nlm.nih.gov/pubmed/29649907 DMNKABH DI DMNKABH DMNKABH DN PMID29671355-Compound-11 DMNKABH MI TT6R7JZ DMNKABH MN Histone deacetylase 1 (HDAC1) DMNKABH MT DTT DMNKABH MA Inhibitor DMNKABH RN HDAC inhibitors: a 2013-2017 patent survey.Expert Opin Ther Pat. 2018 Apr 19:1-17. DMNKABH RU https://www.ncbi.nlm.nih.gov/pubmed/29671355 DMNKABH DI DMNKABH DMNKABH DN PMID29671355-Compound-11 DMNKABH MI TTSHTOI DMNKABH MN Histone deacetylase 2 (HDAC2) DMNKABH MT DTT DMNKABH MA Inhibitor DMNKABH RN HDAC inhibitors: a 2013-2017 patent survey.Expert Opin Ther Pat. 2018 Apr 19:1-17. DMNKABH RU https://www.ncbi.nlm.nih.gov/pubmed/29671355 DMNKABH DI DMNKABH DMNKABH DN PMID29671355-Compound-11 DMNKABH MI TT4YWTO DMNKABH MN Histone deacetylase 3 (HDAC3) DMNKABH MT DTT DMNKABH MA Inhibitor DMNKABH RN HDAC inhibitors: a 2013-2017 patent survey.Expert Opin Ther Pat. 2018 Apr 19:1-17. DMNKABH RU https://www.ncbi.nlm.nih.gov/pubmed/29671355 DMNKABH DI DMNKABH DMNKABH DN PMID29671355-Compound-11 DMNKABH MI TT5ZKDI DMNKABH MN Histone deacetylase 6 (HDAC6) DMNKABH MT DTT DMNKABH MA Inhibitor DMNKABH RN HDAC inhibitors: a 2013-2017 patent survey.Expert Opin Ther Pat. 2018 Apr 19:1-17. DMNKABH RU https://www.ncbi.nlm.nih.gov/pubmed/29671355 DMBQOW4 DI DMBQOW4 DMBQOW4 DN PMID29671355-Compound-12 DMBQOW4 MI TTTQGH8 DMBQOW4 MN Histone deacetylase 4 (HDAC4) DMBQOW4 MT DTT DMBQOW4 MA Inhibitor DMBQOW4 RN HDAC inhibitors: a 2013-2017 patent survey.Expert Opin Ther Pat. 2018 Apr 19:1-17. DMBQOW4 RU https://www.ncbi.nlm.nih.gov/pubmed/29671355 DMALXYR DI DMALXYR DMALXYR DN PMID29671355-Compound-13 DMALXYR MI TT6R7JZ DMALXYR MN Histone deacetylase 1 (HDAC1) DMALXYR MT DTT DMALXYR MA Inhibitor DMALXYR RN HDAC inhibitors: a 2013-2017 patent survey.Expert Opin Ther Pat. 2018 Apr 19:1-17. DMALXYR RU https://www.ncbi.nlm.nih.gov/pubmed/29671355 DMALXYR DI DMALXYR DMALXYR DN PMID29671355-Compound-13 DMALXYR MI TT5ZKDI DMALXYR MN Histone deacetylase 6 (HDAC6) DMALXYR MT DTT DMALXYR MA Inhibitor DMALXYR RN HDAC inhibitors: a 2013-2017 patent survey.Expert Opin Ther Pat. 2018 Apr 19:1-17. DMALXYR RU https://www.ncbi.nlm.nih.gov/pubmed/29671355 DMALXYR DI DMALXYR DMALXYR DN PMID29671355-Compound-13 DMALXYR MI TTT6LFV DMALXYR MN Histone deacetylase 8 (HDAC8) DMALXYR MT DTT DMALXYR MA Inhibitor DMALXYR RN HDAC inhibitors: a 2013-2017 patent survey.Expert Opin Ther Pat. 2018 Apr 19:1-17. DMALXYR RU https://www.ncbi.nlm.nih.gov/pubmed/29671355 DM8UMQH DI DM8UMQH DM8UMQH DN PMID29671355-Compound-14 DM8UMQH MI TT5ZKDI DM8UMQH MN Histone deacetylase 6 (HDAC6) DM8UMQH MT DTT DM8UMQH MA Inhibitor DM8UMQH RN HDAC inhibitors: a 2013-2017 patent survey.Expert Opin Ther Pat. 2018 Apr 19:1-17. DM8UMQH RU https://www.ncbi.nlm.nih.gov/pubmed/29671355 DMAEPD4 DI DMAEPD4 DMAEPD4 DN PMID29671355-Compound-15 DMAEPD4 MI TT5ZKDI DMAEPD4 MN Histone deacetylase 6 (HDAC6) DMAEPD4 MT DTT DMAEPD4 MA Inhibitor DMAEPD4 RN HDAC inhibitors: a 2013-2017 patent survey.Expert Opin Ther Pat. 2018 Apr 19:1-17. DMAEPD4 RU https://www.ncbi.nlm.nih.gov/pubmed/29671355 DM2C6ZF DI DM2C6ZF DM2C6ZF DN PMID29671355-Compound-16 DM2C6ZF MI TT5ZKDI DM2C6ZF MN Histone deacetylase 6 (HDAC6) DM2C6ZF MT DTT DM2C6ZF MA Inhibitor DM2C6ZF RN HDAC inhibitors: a 2013-2017 patent survey.Expert Opin Ther Pat. 2018 Apr 19:1-17. DM2C6ZF RU https://www.ncbi.nlm.nih.gov/pubmed/29671355 DMUY53P DI DMUY53P DMUY53P DN PMID29671355-Compound-18 DMUY53P MI TT6R7JZ DMUY53P MN Histone deacetylase 1 (HDAC1) DMUY53P MT DTT DMUY53P MA Inhibitor DMUY53P RN HDAC inhibitors: a 2013-2017 patent survey.Expert Opin Ther Pat. 2018 Apr 19:1-17. DMUY53P RU https://www.ncbi.nlm.nih.gov/pubmed/29671355 DMUY53P DI DMUY53P DMUY53P DN PMID29671355-Compound-18 DMUY53P MI TT5ZKDI DMUY53P MN Histone deacetylase 6 (HDAC6) DMUY53P MT DTT DMUY53P MA Inhibitor DMUY53P RN HDAC inhibitors: a 2013-2017 patent survey.Expert Opin Ther Pat. 2018 Apr 19:1-17. DMUY53P RU https://www.ncbi.nlm.nih.gov/pubmed/29671355 DM9LMNB DI DM9LMNB DM9LMNB DN PMID29671355-Compound-19 DM9LMNB MI TT6R7JZ DM9LMNB MN Histone deacetylase 1 (HDAC1) DM9LMNB MT DTT DM9LMNB MA Inhibitor DM9LMNB RN HDAC inhibitors: a 2013-2017 patent survey.Expert Opin Ther Pat. 2018 Apr 19:1-17. DM9LMNB RU https://www.ncbi.nlm.nih.gov/pubmed/29671355 DM9LMNB DI DM9LMNB DM9LMNB DN PMID29671355-Compound-19 DM9LMNB MI TT5ZKDI DM9LMNB MN Histone deacetylase 6 (HDAC6) DM9LMNB MT DTT DM9LMNB MA Inhibitor DM9LMNB RN HDAC inhibitors: a 2013-2017 patent survey.Expert Opin Ther Pat. 2018 Apr 19:1-17. DM9LMNB RU https://www.ncbi.nlm.nih.gov/pubmed/29671355 DMPJN0M DI DMPJN0M DMPJN0M DN PMID29671355-Compound-21 DMPJN0M MI TT6R7JZ DMPJN0M MN Histone deacetylase 1 (HDAC1) DMPJN0M MT DTT DMPJN0M MA Inhibitor DMPJN0M RN HDAC inhibitors: a 2013-2017 patent survey.Expert Opin Ther Pat. 2018 Apr 19:1-17. DMPJN0M RU https://www.ncbi.nlm.nih.gov/pubmed/29671355 DMPJN0M DI DMPJN0M DMPJN0M DN PMID29671355-Compound-21 DMPJN0M MI TTYHPU6 DMPJN0M MN Histone deacetylase 10 (HDAC10) DMPJN0M MT DTT DMPJN0M MA Inhibitor DMPJN0M RN HDAC inhibitors: a 2013-2017 patent survey.Expert Opin Ther Pat. 2018 Apr 19:1-17. DMPJN0M RU https://www.ncbi.nlm.nih.gov/pubmed/29671355 DMPJN0M DI DMPJN0M DMPJN0M DN PMID29671355-Compound-21 DMPJN0M MI TT8K17W DMPJN0M MN Histone deacetylase 11 (HDAC11) DMPJN0M MT DTT DMPJN0M MA Inhibitor DMPJN0M RN HDAC inhibitors: a 2013-2017 patent survey.Expert Opin Ther Pat. 2018 Apr 19:1-17. DMPJN0M RU https://www.ncbi.nlm.nih.gov/pubmed/29671355 DMPJN0M DI DMPJN0M DMPJN0M DN PMID29671355-Compound-21 DMPJN0M MI TTSHTOI DMPJN0M MN Histone deacetylase 2 (HDAC2) DMPJN0M MT DTT DMPJN0M MA Inhibitor DMPJN0M RN HDAC inhibitors: a 2013-2017 patent survey.Expert Opin Ther Pat. 2018 Apr 19:1-17. DMPJN0M RU https://www.ncbi.nlm.nih.gov/pubmed/29671355 DMPJN0M DI DMPJN0M DMPJN0M DN PMID29671355-Compound-21 DMPJN0M MI TT4YWTO DMPJN0M MN Histone deacetylase 3 (HDAC3) DMPJN0M MT DTT DMPJN0M MA Inhibitor DMPJN0M RN HDAC inhibitors: a 2013-2017 patent survey.Expert Opin Ther Pat. 2018 Apr 19:1-17. DMPJN0M RU https://www.ncbi.nlm.nih.gov/pubmed/29671355 DMPJN0M DI DMPJN0M DMPJN0M DN PMID29671355-Compound-21 DMPJN0M MI TTTQGH8 DMPJN0M MN Histone deacetylase 4 (HDAC4) DMPJN0M MT DTT DMPJN0M MA Inhibitor DMPJN0M RN HDAC inhibitors: a 2013-2017 patent survey.Expert Opin Ther Pat. 2018 Apr 19:1-17. DMPJN0M RU https://www.ncbi.nlm.nih.gov/pubmed/29671355 DMPJN0M DI DMPJN0M DMPJN0M DN PMID29671355-Compound-21 DMPJN0M MI TT5ZKDI DMPJN0M MN Histone deacetylase 6 (HDAC6) DMPJN0M MT DTT DMPJN0M MA Inhibitor DMPJN0M RN HDAC inhibitors: a 2013-2017 patent survey.Expert Opin Ther Pat. 2018 Apr 19:1-17. DMPJN0M RU https://www.ncbi.nlm.nih.gov/pubmed/29671355 DMPJN0M DI DMPJN0M DMPJN0M DN PMID29671355-Compound-21 DMPJN0M MI TTMUEK1 DMPJN0M MN Histone deacetylase 7 (HDAC7) DMPJN0M MT DTT DMPJN0M MA Inhibitor DMPJN0M RN HDAC inhibitors: a 2013-2017 patent survey.Expert Opin Ther Pat. 2018 Apr 19:1-17. DMPJN0M RU https://www.ncbi.nlm.nih.gov/pubmed/29671355 DMPJN0M DI DMPJN0M DMPJN0M DN PMID29671355-Compound-21 DMPJN0M MI TTT6LFV DMPJN0M MN Histone deacetylase 8 (HDAC8) DMPJN0M MT DTT DMPJN0M MA Inhibitor DMPJN0M RN HDAC inhibitors: a 2013-2017 patent survey.Expert Opin Ther Pat. 2018 Apr 19:1-17. DMPJN0M RU https://www.ncbi.nlm.nih.gov/pubmed/29671355 DMPJN0M DI DMPJN0M DMPJN0M DN PMID29671355-Compound-21 DMPJN0M MI TT8M4E1 DMPJN0M MN Histone deacetylase 9 (HDAC9) DMPJN0M MT DTT DMPJN0M MA Inhibitor DMPJN0M RN HDAC inhibitors: a 2013-2017 patent survey.Expert Opin Ther Pat. 2018 Apr 19:1-17. DMPJN0M RU https://www.ncbi.nlm.nih.gov/pubmed/29671355 DMRGV83 DI DMRGV83 DMRGV83 DN PMID29671355-Compound-22 DMRGV83 MI TT6R7JZ DMRGV83 MN Histone deacetylase 1 (HDAC1) DMRGV83 MT DTT DMRGV83 MA Inhibitor DMRGV83 RN HDAC inhibitors: a 2013-2017 patent survey.Expert Opin Ther Pat. 2018 Apr 19:1-17. DMRGV83 RU https://www.ncbi.nlm.nih.gov/pubmed/29671355 DMRGV83 DI DMRGV83 DMRGV83 DN PMID29671355-Compound-22 DMRGV83 MI TT5ZKDI DMRGV83 MN Histone deacetylase 6 (HDAC6) DMRGV83 MT DTT DMRGV83 MA Inhibitor DMRGV83 RN HDAC inhibitors: a 2013-2017 patent survey.Expert Opin Ther Pat. 2018 Apr 19:1-17. DMRGV83 RU https://www.ncbi.nlm.nih.gov/pubmed/29671355 DMUBOEX DI DMUBOEX DMUBOEX DN PMID29671355-Compound-23 DMUBOEX MI TT6R7JZ DMUBOEX MN Histone deacetylase 1 (HDAC1) DMUBOEX MT DTT DMUBOEX MA Inhibitor DMUBOEX RN HDAC inhibitors: a 2013-2017 patent survey.Expert Opin Ther Pat. 2018 Apr 19:1-17. DMUBOEX RU https://www.ncbi.nlm.nih.gov/pubmed/29671355 DMUBOEX DI DMUBOEX DMUBOEX DN PMID29671355-Compound-23 DMUBOEX MI TT8K17W DMUBOEX MN Histone deacetylase 11 (HDAC11) DMUBOEX MT DTT DMUBOEX MA Inhibitor DMUBOEX RN HDAC inhibitors: a 2013-2017 patent survey.Expert Opin Ther Pat. 2018 Apr 19:1-17. DMUBOEX RU https://www.ncbi.nlm.nih.gov/pubmed/29671355 DMUBOEX DI DMUBOEX DMUBOEX DN PMID29671355-Compound-23 DMUBOEX MI TTSHTOI DMUBOEX MN Histone deacetylase 2 (HDAC2) DMUBOEX MT DTT DMUBOEX MA Inhibitor DMUBOEX RN HDAC inhibitors: a 2013-2017 patent survey.Expert Opin Ther Pat. 2018 Apr 19:1-17. DMUBOEX RU https://www.ncbi.nlm.nih.gov/pubmed/29671355 DMUBOEX DI DMUBOEX DMUBOEX DN PMID29671355-Compound-23 DMUBOEX MI TTTQGH8 DMUBOEX MN Histone deacetylase 4 (HDAC4) DMUBOEX MT DTT DMUBOEX MA Inhibitor DMUBOEX RN HDAC inhibitors: a 2013-2017 patent survey.Expert Opin Ther Pat. 2018 Apr 19:1-17. DMUBOEX RU https://www.ncbi.nlm.nih.gov/pubmed/29671355 DMUBOEX DI DMUBOEX DMUBOEX DN PMID29671355-Compound-23 DMUBOEX MI TTUELN5 DMUBOEX MN Histone deacetylase 5 (HDAC5) DMUBOEX MT DTT DMUBOEX MA Inhibitor DMUBOEX RN HDAC inhibitors: a 2013-2017 patent survey.Expert Opin Ther Pat. 2018 Apr 19:1-17. DMUBOEX RU https://www.ncbi.nlm.nih.gov/pubmed/29671355 DMUBOEX DI DMUBOEX DMUBOEX DN PMID29671355-Compound-23 DMUBOEX MI TT5ZKDI DMUBOEX MN Histone deacetylase 6 (HDAC6) DMUBOEX MT DTT DMUBOEX MA Inhibitor DMUBOEX RN HDAC inhibitors: a 2013-2017 patent survey.Expert Opin Ther Pat. 2018 Apr 19:1-17. DMUBOEX RU https://www.ncbi.nlm.nih.gov/pubmed/29671355 DMUBOEX DI DMUBOEX DMUBOEX DN PMID29671355-Compound-23 DMUBOEX MI TTT6LFV DMUBOEX MN Histone deacetylase 8 (HDAC8) DMUBOEX MT DTT DMUBOEX MA Inhibitor DMUBOEX RN HDAC inhibitors: a 2013-2017 patent survey.Expert Opin Ther Pat. 2018 Apr 19:1-17. DMUBOEX RU https://www.ncbi.nlm.nih.gov/pubmed/29671355 DMCIGJ1 DI DMCIGJ1 DMCIGJ1 DN PMID29671355-Compound-24 DMCIGJ1 MI TT6R7JZ DMCIGJ1 MN Histone deacetylase 1 (HDAC1) DMCIGJ1 MT DTT DMCIGJ1 MA Inhibitor DMCIGJ1 RN HDAC inhibitors: a 2013-2017 patent survey.Expert Opin Ther Pat. 2018 Apr 19:1-17. DMCIGJ1 RU https://www.ncbi.nlm.nih.gov/pubmed/29671355 DMCIGJ1 DI DMCIGJ1 DMCIGJ1 DN PMID29671355-Compound-24 DMCIGJ1 MI TT5ZKDI DMCIGJ1 MN Histone deacetylase 6 (HDAC6) DMCIGJ1 MT DTT DMCIGJ1 MA Inhibitor DMCIGJ1 RN HDAC inhibitors: a 2013-2017 patent survey.Expert Opin Ther Pat. 2018 Apr 19:1-17. DMCIGJ1 RU https://www.ncbi.nlm.nih.gov/pubmed/29671355 DMPV0KZ DI DMPV0KZ DMPV0KZ DN PMID29671355-Compound-25 DMPV0KZ MI TT6R7JZ DMPV0KZ MN Histone deacetylase 1 (HDAC1) DMPV0KZ MT DTT DMPV0KZ MA Inhibitor DMPV0KZ RN HDAC inhibitors: a 2013-2017 patent survey.Expert Opin Ther Pat. 2018 Apr 19:1-17. DMPV0KZ RU https://www.ncbi.nlm.nih.gov/pubmed/29671355 DMPV0KZ DI DMPV0KZ DMPV0KZ DN PMID29671355-Compound-25 DMPV0KZ MI TTYHPU6 DMPV0KZ MN Histone deacetylase 10 (HDAC10) DMPV0KZ MT DTT DMPV0KZ MA Inhibitor DMPV0KZ RN HDAC inhibitors: a 2013-2017 patent survey.Expert Opin Ther Pat. 2018 Apr 19:1-17. DMPV0KZ RU https://www.ncbi.nlm.nih.gov/pubmed/29671355 DMPV0KZ DI DMPV0KZ DMPV0KZ DN PMID29671355-Compound-25 DMPV0KZ MI TT8K17W DMPV0KZ MN Histone deacetylase 11 (HDAC11) DMPV0KZ MT DTT DMPV0KZ MA Inhibitor DMPV0KZ RN HDAC inhibitors: a 2013-2017 patent survey.Expert Opin Ther Pat. 2018 Apr 19:1-17. DMPV0KZ RU https://www.ncbi.nlm.nih.gov/pubmed/29671355 DMPV0KZ DI DMPV0KZ DMPV0KZ DN PMID29671355-Compound-25 DMPV0KZ MI TTSHTOI DMPV0KZ MN Histone deacetylase 2 (HDAC2) DMPV0KZ MT DTT DMPV0KZ MA Inhibitor DMPV0KZ RN HDAC inhibitors: a 2013-2017 patent survey.Expert Opin Ther Pat. 2018 Apr 19:1-17. DMPV0KZ RU https://www.ncbi.nlm.nih.gov/pubmed/29671355 DMPV0KZ DI DMPV0KZ DMPV0KZ DN PMID29671355-Compound-25 DMPV0KZ MI TT4YWTO DMPV0KZ MN Histone deacetylase 3 (HDAC3) DMPV0KZ MT DTT DMPV0KZ MA Inhibitor DMPV0KZ RN HDAC inhibitors: a 2013-2017 patent survey.Expert Opin Ther Pat. 2018 Apr 19:1-17. DMPV0KZ RU https://www.ncbi.nlm.nih.gov/pubmed/29671355 DMPV0KZ DI DMPV0KZ DMPV0KZ DN PMID29671355-Compound-25 DMPV0KZ MI TTTQGH8 DMPV0KZ MN Histone deacetylase 4 (HDAC4) DMPV0KZ MT DTT DMPV0KZ MA Inhibitor DMPV0KZ RN HDAC inhibitors: a 2013-2017 patent survey.Expert Opin Ther Pat. 2018 Apr 19:1-17. DMPV0KZ RU https://www.ncbi.nlm.nih.gov/pubmed/29671355 DMPV0KZ DI DMPV0KZ DMPV0KZ DN PMID29671355-Compound-25 DMPV0KZ MI TTUELN5 DMPV0KZ MN Histone deacetylase 5 (HDAC5) DMPV0KZ MT DTT DMPV0KZ MA Inhibitor DMPV0KZ RN HDAC inhibitors: a 2013-2017 patent survey.Expert Opin Ther Pat. 2018 Apr 19:1-17. DMPV0KZ RU https://www.ncbi.nlm.nih.gov/pubmed/29671355 DMPV0KZ DI DMPV0KZ DMPV0KZ DN PMID29671355-Compound-25 DMPV0KZ MI TT5ZKDI DMPV0KZ MN Histone deacetylase 6 (HDAC6) DMPV0KZ MT DTT DMPV0KZ MA Inhibitor DMPV0KZ RN HDAC inhibitors: a 2013-2017 patent survey.Expert Opin Ther Pat. 2018 Apr 19:1-17. DMPV0KZ RU https://www.ncbi.nlm.nih.gov/pubmed/29671355 DMPV0KZ DI DMPV0KZ DMPV0KZ DN PMID29671355-Compound-25 DMPV0KZ MI TTMUEK1 DMPV0KZ MN Histone deacetylase 7 (HDAC7) DMPV0KZ MT DTT DMPV0KZ MA Inhibitor DMPV0KZ RN HDAC inhibitors: a 2013-2017 patent survey.Expert Opin Ther Pat. 2018 Apr 19:1-17. DMPV0KZ RU https://www.ncbi.nlm.nih.gov/pubmed/29671355 DMPV0KZ DI DMPV0KZ DMPV0KZ DN PMID29671355-Compound-25 DMPV0KZ MI TTT6LFV DMPV0KZ MN Histone deacetylase 8 (HDAC8) DMPV0KZ MT DTT DMPV0KZ MA Inhibitor DMPV0KZ RN HDAC inhibitors: a 2013-2017 patent survey.Expert Opin Ther Pat. 2018 Apr 19:1-17. DMPV0KZ RU https://www.ncbi.nlm.nih.gov/pubmed/29671355 DMPV0KZ DI DMPV0KZ DMPV0KZ DN PMID29671355-Compound-25 DMPV0KZ MI TT8M4E1 DMPV0KZ MN Histone deacetylase 9 (HDAC9) DMPV0KZ MT DTT DMPV0KZ MA Inhibitor DMPV0KZ RN HDAC inhibitors: a 2013-2017 patent survey.Expert Opin Ther Pat. 2018 Apr 19:1-17. DMPV0KZ RU https://www.ncbi.nlm.nih.gov/pubmed/29671355 DM5K6MG DI DM5K6MG DM5K6MG DN PMID29671355-Compound-26 DM5K6MG MI TT6R7JZ DM5K6MG MN Histone deacetylase 1 (HDAC1) DM5K6MG MT DTT DM5K6MG MA Inhibitor DM5K6MG RN HDAC inhibitors: a 2013-2017 patent survey.Expert Opin Ther Pat. 2018 Apr 19:1-17. DM5K6MG RU https://www.ncbi.nlm.nih.gov/pubmed/29671355 DM5K6MG DI DM5K6MG DM5K6MG DN PMID29671355-Compound-26 DM5K6MG MI TT5ZKDI DM5K6MG MN Histone deacetylase 6 (HDAC6) DM5K6MG MT DTT DM5K6MG MA Inhibitor DM5K6MG RN HDAC inhibitors: a 2013-2017 patent survey.Expert Opin Ther Pat. 2018 Apr 19:1-17. DM5K6MG RU https://www.ncbi.nlm.nih.gov/pubmed/29671355 DMP7S9E DI DMP7S9E DMP7S9E DN PMID29671355-Compound-27 DMP7S9E MI TT6R7JZ DMP7S9E MN Histone deacetylase 1 (HDAC1) DMP7S9E MT DTT DMP7S9E MA Inhibitor DMP7S9E RN HDAC inhibitors: a 2013-2017 patent survey.Expert Opin Ther Pat. 2018 Apr 19:1-17. DMP7S9E RU https://www.ncbi.nlm.nih.gov/pubmed/29671355 DMP7S9E DI DMP7S9E DMP7S9E DN PMID29671355-Compound-27 DMP7S9E MI TT5ZKDI DMP7S9E MN Histone deacetylase 6 (HDAC6) DMP7S9E MT DTT DMP7S9E MA Inhibitor DMP7S9E RN HDAC inhibitors: a 2013-2017 patent survey.Expert Opin Ther Pat. 2018 Apr 19:1-17. DMP7S9E RU https://www.ncbi.nlm.nih.gov/pubmed/29671355 DMLXSHW DI DMLXSHW DMLXSHW DN PMID29671355-Compound-28 DMLXSHW MI TT6R7JZ DMLXSHW MN Histone deacetylase 1 (HDAC1) DMLXSHW MT DTT DMLXSHW MA Inhibitor DMLXSHW RN HDAC inhibitors: a 2013-2017 patent survey.Expert Opin Ther Pat. 2018 Apr 19:1-17. DMLXSHW RU https://www.ncbi.nlm.nih.gov/pubmed/29671355 DMLXSHW DI DMLXSHW DMLXSHW DN PMID29671355-Compound-28 DMLXSHW MI TT5ZKDI DMLXSHW MN Histone deacetylase 6 (HDAC6) DMLXSHW MT DTT DMLXSHW MA Inhibitor DMLXSHW RN HDAC inhibitors: a 2013-2017 patent survey.Expert Opin Ther Pat. 2018 Apr 19:1-17. DMLXSHW RU https://www.ncbi.nlm.nih.gov/pubmed/29671355 DM3H78D DI DM3H78D DM3H78D DN PMID29671355-Compound-31 DM3H78D MI TT6R7JZ DM3H78D MN Histone deacetylase 1 (HDAC1) DM3H78D MT DTT DM3H78D MA Inhibitor DM3H78D RN HDAC inhibitors: a 2013-2017 patent survey.Expert Opin Ther Pat. 2018 Apr 19:1-17. DM3H78D RU https://www.ncbi.nlm.nih.gov/pubmed/29671355 DM3H78D DI DM3H78D DM3H78D DN PMID29671355-Compound-31 DM3H78D MI TTSHTOI DM3H78D MN Histone deacetylase 2 (HDAC2) DM3H78D MT DTT DM3H78D MA Inhibitor DM3H78D RN HDAC inhibitors: a 2013-2017 patent survey.Expert Opin Ther Pat. 2018 Apr 19:1-17. DM3H78D RU https://www.ncbi.nlm.nih.gov/pubmed/29671355 DM3H78D DI DM3H78D DM3H78D DN PMID29671355-Compound-31 DM3H78D MI TT4YWTO DM3H78D MN Histone deacetylase 3 (HDAC3) DM3H78D MT DTT DM3H78D MA Inhibitor DM3H78D RN HDAC inhibitors: a 2013-2017 patent survey.Expert Opin Ther Pat. 2018 Apr 19:1-17. DM3H78D RU https://www.ncbi.nlm.nih.gov/pubmed/29671355 DM3H78D DI DM3H78D DM3H78D DN PMID29671355-Compound-31 DM3H78D MI TTTQGH8 DM3H78D MN Histone deacetylase 4 (HDAC4) DM3H78D MT DTT DM3H78D MA Inhibitor DM3H78D RN HDAC inhibitors: a 2013-2017 patent survey.Expert Opin Ther Pat. 2018 Apr 19:1-17. DM3H78D RU https://www.ncbi.nlm.nih.gov/pubmed/29671355 DM3H78D DI DM3H78D DM3H78D DN PMID29671355-Compound-31 DM3H78D MI TTUELN5 DM3H78D MN Histone deacetylase 5 (HDAC5) DM3H78D MT DTT DM3H78D MA Inhibitor DM3H78D RN HDAC inhibitors: a 2013-2017 patent survey.Expert Opin Ther Pat. 2018 Apr 19:1-17. DM3H78D RU https://www.ncbi.nlm.nih.gov/pubmed/29671355 DM3H78D DI DM3H78D DM3H78D DN PMID29671355-Compound-31 DM3H78D MI TT5ZKDI DM3H78D MN Histone deacetylase 6 (HDAC6) DM3H78D MT DTT DM3H78D MA Inhibitor DM3H78D RN HDAC inhibitors: a 2013-2017 patent survey.Expert Opin Ther Pat. 2018 Apr 19:1-17. DM3H78D RU https://www.ncbi.nlm.nih.gov/pubmed/29671355 DM3H78D DI DM3H78D DM3H78D DN PMID29671355-Compound-31 DM3H78D MI TTMUEK1 DM3H78D MN Histone deacetylase 7 (HDAC7) DM3H78D MT DTT DM3H78D MA Inhibitor DM3H78D RN HDAC inhibitors: a 2013-2017 patent survey.Expert Opin Ther Pat. 2018 Apr 19:1-17. DM3H78D RU https://www.ncbi.nlm.nih.gov/pubmed/29671355 DM3H78D DI DM3H78D DM3H78D DN PMID29671355-Compound-31 DM3H78D MI TTT6LFV DM3H78D MN Histone deacetylase 8 (HDAC8) DM3H78D MT DTT DM3H78D MA Inhibitor DM3H78D RN HDAC inhibitors: a 2013-2017 patent survey.Expert Opin Ther Pat. 2018 Apr 19:1-17. DM3H78D RU https://www.ncbi.nlm.nih.gov/pubmed/29671355 DM3H78D DI DM3H78D DM3H78D DN PMID29671355-Compound-31 DM3H78D MI TT8M4E1 DM3H78D MN Histone deacetylase 9 (HDAC9) DM3H78D MT DTT DM3H78D MA Inhibitor DM3H78D RN HDAC inhibitors: a 2013-2017 patent survey.Expert Opin Ther Pat. 2018 Apr 19:1-17. DM3H78D RU https://www.ncbi.nlm.nih.gov/pubmed/29671355 DMQJ3TC DI DMQJ3TC DMQJ3TC DN PMID29671355-Compound-36 DMQJ3TC MI TT8K17W DMQJ3TC MN Histone deacetylase 11 (HDAC11) DMQJ3TC MT DTT DMQJ3TC MA Inhibitor DMQJ3TC RN HDAC inhibitors: a 2013-2017 patent survey.Expert Opin Ther Pat. 2018 Apr 19:1-17. DMQJ3TC RU https://www.ncbi.nlm.nih.gov/pubmed/29671355 DMQJ3TC DI DMQJ3TC DMQJ3TC DN PMID29671355-Compound-36 DMQJ3TC MI TTT6LFV DMQJ3TC MN Histone deacetylase 8 (HDAC8) DMQJ3TC MT DTT DMQJ3TC MA Inhibitor DMQJ3TC RN HDAC inhibitors: a 2013-2017 patent survey.Expert Opin Ther Pat. 2018 Apr 19:1-17. DMQJ3TC RU https://www.ncbi.nlm.nih.gov/pubmed/29671355 DMJ1O5R DI DMJ1O5R DMJ1O5R DN PMID29671355-Compound-37 DMJ1O5R MI TTT6LFV DMJ1O5R MN Histone deacetylase 8 (HDAC8) DMJ1O5R MT DTT DMJ1O5R MA Inhibitor DMJ1O5R RN HDAC inhibitors: a 2013-2017 patent survey.Expert Opin Ther Pat. 2018 Apr 19:1-17. DMJ1O5R RU https://www.ncbi.nlm.nih.gov/pubmed/29671355 DMYATB5 DI DMYATB5 DMYATB5 DN PMID29671355-Compound-38a DMYATB5 MI TT6R7JZ DMYATB5 MN Histone deacetylase 1 (HDAC1) DMYATB5 MT DTT DMYATB5 MA Inhibitor DMYATB5 RN HDAC inhibitors: a 2013-2017 patent survey.Expert Opin Ther Pat. 2018 Apr 19:1-17. DMYATB5 RU https://www.ncbi.nlm.nih.gov/pubmed/29671355 DMYATB5 DI DMYATB5 DMYATB5 DN PMID29671355-Compound-38a DMYATB5 MI TT5ZKDI DMYATB5 MN Histone deacetylase 6 (HDAC6) DMYATB5 MT DTT DMYATB5 MA Inhibitor DMYATB5 RN HDAC inhibitors: a 2013-2017 patent survey.Expert Opin Ther Pat. 2018 Apr 19:1-17. DMYATB5 RU https://www.ncbi.nlm.nih.gov/pubmed/29671355 DMYXE4J DI DMYXE4J DMYXE4J DN PMID29671355-Compound-38b DMYXE4J MI TT6R7JZ DMYXE4J MN Histone deacetylase 1 (HDAC1) DMYXE4J MT DTT DMYXE4J MA Inhibitor DMYXE4J RN HDAC inhibitors: a 2013-2017 patent survey.Expert Opin Ther Pat. 2018 Apr 19:1-17. DMYXE4J RU https://www.ncbi.nlm.nih.gov/pubmed/29671355 DMYXE4J DI DMYXE4J DMYXE4J DN PMID29671355-Compound-38b DMYXE4J MI TT5ZKDI DMYXE4J MN Histone deacetylase 6 (HDAC6) DMYXE4J MT DTT DMYXE4J MA Inhibitor DMYXE4J RN HDAC inhibitors: a 2013-2017 patent survey.Expert Opin Ther Pat. 2018 Apr 19:1-17. DMYXE4J RU https://www.ncbi.nlm.nih.gov/pubmed/29671355 DM6EJ93 DI DM6EJ93 DM6EJ93 DN PMID29671355-Compound-39 DM6EJ93 MI TT6R7JZ DM6EJ93 MN Histone deacetylase 1 (HDAC1) DM6EJ93 MT DTT DM6EJ93 MA Inhibitor DM6EJ93 RN HDAC inhibitors: a 2013-2017 patent survey.Expert Opin Ther Pat. 2018 Apr 19:1-17. DM6EJ93 RU https://www.ncbi.nlm.nih.gov/pubmed/29671355 DM6EJ93 DI DM6EJ93 DM6EJ93 DN PMID29671355-Compound-39 DM6EJ93 MI TT5ZKDI DM6EJ93 MN Histone deacetylase 6 (HDAC6) DM6EJ93 MT DTT DM6EJ93 MA Inhibitor DM6EJ93 RN HDAC inhibitors: a 2013-2017 patent survey.Expert Opin Ther Pat. 2018 Apr 19:1-17. DM6EJ93 RU https://www.ncbi.nlm.nih.gov/pubmed/29671355 DMXY103 DI DMXY103 DMXY103 DN PMID29671355-Compound-42 DMXY103 MI TT6R7JZ DMXY103 MN Histone deacetylase 1 (HDAC1) DMXY103 MT DTT DMXY103 MA Inhibitor DMXY103 RN HDAC inhibitors: a 2013-2017 patent survey.Expert Opin Ther Pat. 2018 Apr 19:1-17. DMXY103 RU https://www.ncbi.nlm.nih.gov/pubmed/29671355 DMVPMWJ DI DMVPMWJ DMVPMWJ DN PMID29671355-Compound-43 DMVPMWJ MI TT6R7JZ DMVPMWJ MN Histone deacetylase 1 (HDAC1) DMVPMWJ MT DTT DMVPMWJ MA Inhibitor DMVPMWJ RN HDAC inhibitors: a 2013-2017 patent survey.Expert Opin Ther Pat. 2018 Apr 19:1-17. DMVPMWJ RU https://www.ncbi.nlm.nih.gov/pubmed/29671355 DMVPMWJ DI DMVPMWJ DMVPMWJ DN PMID29671355-Compound-43 DMVPMWJ MI TTYHPU6 DMVPMWJ MN Histone deacetylase 10 (HDAC10) DMVPMWJ MT DTT DMVPMWJ MA Inhibitor DMVPMWJ RN HDAC inhibitors: a 2013-2017 patent survey.Expert Opin Ther Pat. 2018 Apr 19:1-17. DMVPMWJ RU https://www.ncbi.nlm.nih.gov/pubmed/29671355 DMVPMWJ DI DMVPMWJ DMVPMWJ DN PMID29671355-Compound-43 DMVPMWJ MI TT8K17W DMVPMWJ MN Histone deacetylase 11 (HDAC11) DMVPMWJ MT DTT DMVPMWJ MA Inhibitor DMVPMWJ RN HDAC inhibitors: a 2013-2017 patent survey.Expert Opin Ther Pat. 2018 Apr 19:1-17. DMVPMWJ RU https://www.ncbi.nlm.nih.gov/pubmed/29671355 DMVPMWJ DI DMVPMWJ DMVPMWJ DN PMID29671355-Compound-43 DMVPMWJ MI TTSHTOI DMVPMWJ MN Histone deacetylase 2 (HDAC2) DMVPMWJ MT DTT DMVPMWJ MA Inhibitor DMVPMWJ RN HDAC inhibitors: a 2013-2017 patent survey.Expert Opin Ther Pat. 2018 Apr 19:1-17. DMVPMWJ RU https://www.ncbi.nlm.nih.gov/pubmed/29671355 DMVPMWJ DI DMVPMWJ DMVPMWJ DN PMID29671355-Compound-43 DMVPMWJ MI TT4YWTO DMVPMWJ MN Histone deacetylase 3 (HDAC3) DMVPMWJ MT DTT DMVPMWJ MA Inhibitor DMVPMWJ RN HDAC inhibitors: a 2013-2017 patent survey.Expert Opin Ther Pat. 2018 Apr 19:1-17. DMVPMWJ RU https://www.ncbi.nlm.nih.gov/pubmed/29671355 DMVPMWJ DI DMVPMWJ DMVPMWJ DN PMID29671355-Compound-43 DMVPMWJ MI TTTQGH8 DMVPMWJ MN Histone deacetylase 4 (HDAC4) DMVPMWJ MT DTT DMVPMWJ MA Inhibitor DMVPMWJ RN HDAC inhibitors: a 2013-2017 patent survey.Expert Opin Ther Pat. 2018 Apr 19:1-17. DMVPMWJ RU https://www.ncbi.nlm.nih.gov/pubmed/29671355 DMVPMWJ DI DMVPMWJ DMVPMWJ DN PMID29671355-Compound-43 DMVPMWJ MI TTUELN5 DMVPMWJ MN Histone deacetylase 5 (HDAC5) DMVPMWJ MT DTT DMVPMWJ MA Inhibitor DMVPMWJ RN HDAC inhibitors: a 2013-2017 patent survey.Expert Opin Ther Pat. 2018 Apr 19:1-17. DMVPMWJ RU https://www.ncbi.nlm.nih.gov/pubmed/29671355 DMVPMWJ DI DMVPMWJ DMVPMWJ DN PMID29671355-Compound-43 DMVPMWJ MI TT5ZKDI DMVPMWJ MN Histone deacetylase 6 (HDAC6) DMVPMWJ MT DTT DMVPMWJ MA Inhibitor DMVPMWJ RN HDAC inhibitors: a 2013-2017 patent survey.Expert Opin Ther Pat. 2018 Apr 19:1-17. DMVPMWJ RU https://www.ncbi.nlm.nih.gov/pubmed/29671355 DMVPMWJ DI DMVPMWJ DMVPMWJ DN PMID29671355-Compound-43 DMVPMWJ MI TTMUEK1 DMVPMWJ MN Histone deacetylase 7 (HDAC7) DMVPMWJ MT DTT DMVPMWJ MA Inhibitor DMVPMWJ RN HDAC inhibitors: a 2013-2017 patent survey.Expert Opin Ther Pat. 2018 Apr 19:1-17. DMVPMWJ RU https://www.ncbi.nlm.nih.gov/pubmed/29671355 DMVPMWJ DI DMVPMWJ DMVPMWJ DN PMID29671355-Compound-43 DMVPMWJ MI TTT6LFV DMVPMWJ MN Histone deacetylase 8 (HDAC8) DMVPMWJ MT DTT DMVPMWJ MA Inhibitor DMVPMWJ RN HDAC inhibitors: a 2013-2017 patent survey.Expert Opin Ther Pat. 2018 Apr 19:1-17. DMVPMWJ RU https://www.ncbi.nlm.nih.gov/pubmed/29671355 DMVPMWJ DI DMVPMWJ DMVPMWJ DN PMID29671355-Compound-43 DMVPMWJ MI TT8M4E1 DMVPMWJ MN Histone deacetylase 9 (HDAC9) DMVPMWJ MT DTT DMVPMWJ MA Inhibitor DMVPMWJ RN HDAC inhibitors: a 2013-2017 patent survey.Expert Opin Ther Pat. 2018 Apr 19:1-17. DMVPMWJ RU https://www.ncbi.nlm.nih.gov/pubmed/29671355 DM80A3V DI DM80A3V DM80A3V DN PMID29671355-Compound-44 DM80A3V MI TT6R7JZ DM80A3V MN Histone deacetylase 1 (HDAC1) DM80A3V MT DTT DM80A3V MA Inhibitor DM80A3V RN HDAC inhibitors: a 2013-2017 patent survey.Expert Opin Ther Pat. 2018 Apr 19:1-17. DM80A3V RU https://www.ncbi.nlm.nih.gov/pubmed/29671355 DM80A3V DI DM80A3V DM80A3V DN PMID29671355-Compound-44 DM80A3V MI TTYHPU6 DM80A3V MN Histone deacetylase 10 (HDAC10) DM80A3V MT DTT DM80A3V MA Inhibitor DM80A3V RN HDAC inhibitors: a 2013-2017 patent survey.Expert Opin Ther Pat. 2018 Apr 19:1-17. DM80A3V RU https://www.ncbi.nlm.nih.gov/pubmed/29671355 DM80A3V DI DM80A3V DM80A3V DN PMID29671355-Compound-44 DM80A3V MI TT8K17W DM80A3V MN Histone deacetylase 11 (HDAC11) DM80A3V MT DTT DM80A3V MA Inhibitor DM80A3V RN HDAC inhibitors: a 2013-2017 patent survey.Expert Opin Ther Pat. 2018 Apr 19:1-17. DM80A3V RU https://www.ncbi.nlm.nih.gov/pubmed/29671355 DM80A3V DI DM80A3V DM80A3V DN PMID29671355-Compound-44 DM80A3V MI TTSHTOI DM80A3V MN Histone deacetylase 2 (HDAC2) DM80A3V MT DTT DM80A3V MA Inhibitor DM80A3V RN HDAC inhibitors: a 2013-2017 patent survey.Expert Opin Ther Pat. 2018 Apr 19:1-17. DM80A3V RU https://www.ncbi.nlm.nih.gov/pubmed/29671355 DM80A3V DI DM80A3V DM80A3V DN PMID29671355-Compound-44 DM80A3V MI TT4YWTO DM80A3V MN Histone deacetylase 3 (HDAC3) DM80A3V MT DTT DM80A3V MA Inhibitor DM80A3V RN HDAC inhibitors: a 2013-2017 patent survey.Expert Opin Ther Pat. 2018 Apr 19:1-17. DM80A3V RU https://www.ncbi.nlm.nih.gov/pubmed/29671355 DM80A3V DI DM80A3V DM80A3V DN PMID29671355-Compound-44 DM80A3V MI TT5ZKDI DM80A3V MN Histone deacetylase 6 (HDAC6) DM80A3V MT DTT DM80A3V MA Inhibitor DM80A3V RN HDAC inhibitors: a 2013-2017 patent survey.Expert Opin Ther Pat. 2018 Apr 19:1-17. DM80A3V RU https://www.ncbi.nlm.nih.gov/pubmed/29671355 DM80A3V DI DM80A3V DM80A3V DN PMID29671355-Compound-44 DM80A3V MI TTT6LFV DM80A3V MN Histone deacetylase 8 (HDAC8) DM80A3V MT DTT DM80A3V MA Inhibitor DM80A3V RN HDAC inhibitors: a 2013-2017 patent survey.Expert Opin Ther Pat. 2018 Apr 19:1-17. DM80A3V RU https://www.ncbi.nlm.nih.gov/pubmed/29671355 DM5LYKR DI DM5LYKR DM5LYKR DN PMID29671355-Compound-45a DM5LYKR MI TTTQGH8 DM5LYKR MN Histone deacetylase 4 (HDAC4) DM5LYKR MT DTT DM5LYKR MA Inhibitor DM5LYKR RN HDAC inhibitors: a 2013-2017 patent survey.Expert Opin Ther Pat. 2018 Apr 19:1-17. DM5LYKR RU https://www.ncbi.nlm.nih.gov/pubmed/29671355 DM5LYKR DI DM5LYKR DM5LYKR DN PMID29671355-Compound-45a DM5LYKR MI TTUELN5 DM5LYKR MN Histone deacetylase 5 (HDAC5) DM5LYKR MT DTT DM5LYKR MA Inhibitor DM5LYKR RN HDAC inhibitors: a 2013-2017 patent survey.Expert Opin Ther Pat. 2018 Apr 19:1-17. DM5LYKR RU https://www.ncbi.nlm.nih.gov/pubmed/29671355 DM5LYKR DI DM5LYKR DM5LYKR DN PMID29671355-Compound-45a DM5LYKR MI TTMUEK1 DM5LYKR MN Histone deacetylase 7 (HDAC7) DM5LYKR MT DTT DM5LYKR MA Inhibitor DM5LYKR RN HDAC inhibitors: a 2013-2017 patent survey.Expert Opin Ther Pat. 2018 Apr 19:1-17. DM5LYKR RU https://www.ncbi.nlm.nih.gov/pubmed/29671355 DM5LYKR DI DM5LYKR DM5LYKR DN PMID29671355-Compound-45a DM5LYKR MI TT8M4E1 DM5LYKR MN Histone deacetylase 9 (HDAC9) DM5LYKR MT DTT DM5LYKR MA Inhibitor DM5LYKR RN HDAC inhibitors: a 2013-2017 patent survey.Expert Opin Ther Pat. 2018 Apr 19:1-17. DM5LYKR RU https://www.ncbi.nlm.nih.gov/pubmed/29671355 DM5I1QV DI DM5I1QV DM5I1QV DN PMID29671355-Compound-47a DM5I1QV MI TTTQGH8 DM5I1QV MN Histone deacetylase 4 (HDAC4) DM5I1QV MT DTT DM5I1QV MA Inhibitor DM5I1QV RN HDAC inhibitors: a 2013-2017 patent survey.Expert Opin Ther Pat. 2018 Apr 19:1-17. DM5I1QV RU https://www.ncbi.nlm.nih.gov/pubmed/29671355 DMBUJ39 DI DMBUJ39 DMBUJ39 DN PMID29671355-Compound-47b DMBUJ39 MI TTTQGH8 DMBUJ39 MN Histone deacetylase 4 (HDAC4) DMBUJ39 MT DTT DMBUJ39 MA Inhibitor DMBUJ39 RN HDAC inhibitors: a 2013-2017 patent survey.Expert Opin Ther Pat. 2018 Apr 19:1-17. DMBUJ39 RU https://www.ncbi.nlm.nih.gov/pubmed/29671355 DMAH982 DI DMAH982 DMAH982 DN PMID29671355-Compound-47c DMAH982 MI TTTQGH8 DMAH982 MN Histone deacetylase 4 (HDAC4) DMAH982 MT DTT DMAH982 MA Inhibitor DMAH982 RN HDAC inhibitors: a 2013-2017 patent survey.Expert Opin Ther Pat. 2018 Apr 19:1-17. DMAH982 RU https://www.ncbi.nlm.nih.gov/pubmed/29671355 DMPA9OY DI DMPA9OY DMPA9OY DN PMID29671355-Compound-47d DMPA9OY MI TTTQGH8 DMPA9OY MN Histone deacetylase 4 (HDAC4) DMPA9OY MT DTT DMPA9OY MA Inhibitor DMPA9OY RN HDAC inhibitors: a 2013-2017 patent survey.Expert Opin Ther Pat. 2018 Apr 19:1-17. DMPA9OY RU https://www.ncbi.nlm.nih.gov/pubmed/29671355 DMLDFVN DI DMLDFVN DMLDFVN DN PMID29671355-Compound-50 DMLDFVN MI TTTQGH8 DMLDFVN MN Histone deacetylase 4 (HDAC4) DMLDFVN MT DTT DMLDFVN MA Inhibitor DMLDFVN RN HDAC inhibitors: a 2013-2017 patent survey.Expert Opin Ther Pat. 2018 Apr 19:1-17. DMLDFVN RU https://www.ncbi.nlm.nih.gov/pubmed/29671355 DMEUZM3 DI DMEUZM3 DMEUZM3 DN PMID29671355-Compound-52 DMEUZM3 MI TTTQGH8 DMEUZM3 MN Histone deacetylase 4 (HDAC4) DMEUZM3 MT DTT DMEUZM3 MA Inhibitor DMEUZM3 RN HDAC inhibitors: a 2013-2017 patent survey.Expert Opin Ther Pat. 2018 Apr 19:1-17. DMEUZM3 RU https://www.ncbi.nlm.nih.gov/pubmed/29671355 DMCRWV3 DI DMCRWV3 DMCRWV3 DN PMID29671355-Compound-53 DMCRWV3 MI TTBH0VX DMCRWV3 MN Histone deacetylase (HDAC) DMCRWV3 MT DTT DMCRWV3 MA Inhibitor DMCRWV3 RN HDAC inhibitors: a 2013-2017 patent survey.Expert Opin Ther Pat. 2018 Apr 19:1-17. DMCRWV3 RU https://www.ncbi.nlm.nih.gov/pubmed/29671355 DMJV1SY DI DMJV1SY DMJV1SY DN PMID29671355-Compound-55 DMJV1SY MI TT6R7JZ DMJV1SY MN Histone deacetylase 1 (HDAC1) DMJV1SY MT DTT DMJV1SY MA Inhibitor DMJV1SY RN HDAC inhibitors: a 2013-2017 patent survey.Expert Opin Ther Pat. 2018 Apr 19:1-17. DMJV1SY RU https://www.ncbi.nlm.nih.gov/pubmed/29671355 DMJV1SY DI DMJV1SY DMJV1SY DN PMID29671355-Compound-55 DMJV1SY MI TTSHTOI DMJV1SY MN Histone deacetylase 2 (HDAC2) DMJV1SY MT DTT DMJV1SY MA Inhibitor DMJV1SY RN HDAC inhibitors: a 2013-2017 patent survey.Expert Opin Ther Pat. 2018 Apr 19:1-17. DMJV1SY RU https://www.ncbi.nlm.nih.gov/pubmed/29671355 DMJV1SY DI DMJV1SY DMJV1SY DN PMID29671355-Compound-55 DMJV1SY MI TT4YWTO DMJV1SY MN Histone deacetylase 3 (HDAC3) DMJV1SY MT DTT DMJV1SY MA Inhibitor DMJV1SY RN HDAC inhibitors: a 2013-2017 patent survey.Expert Opin Ther Pat. 2018 Apr 19:1-17. DMJV1SY RU https://www.ncbi.nlm.nih.gov/pubmed/29671355 DM0VBMI DI DM0VBMI DM0VBMI DN PMID29671355-Compound-56 DM0VBMI MI TT6R7JZ DM0VBMI MN Histone deacetylase 1 (HDAC1) DM0VBMI MT DTT DM0VBMI MA Inhibitor DM0VBMI RN HDAC inhibitors: a 2013-2017 patent survey.Expert Opin Ther Pat. 2018 Apr 19:1-17. DM0VBMI RU https://www.ncbi.nlm.nih.gov/pubmed/29671355 DM0VBMI DI DM0VBMI DM0VBMI DN PMID29671355-Compound-56 DM0VBMI MI TTYHPU6 DM0VBMI MN Histone deacetylase 10 (HDAC10) DM0VBMI MT DTT DM0VBMI MA Inhibitor DM0VBMI RN HDAC inhibitors: a 2013-2017 patent survey.Expert Opin Ther Pat. 2018 Apr 19:1-17. DM0VBMI RU https://www.ncbi.nlm.nih.gov/pubmed/29671355 DM0VBMI DI DM0VBMI DM0VBMI DN PMID29671355-Compound-56 DM0VBMI MI TTSHTOI DM0VBMI MN Histone deacetylase 2 (HDAC2) DM0VBMI MT DTT DM0VBMI MA Inhibitor DM0VBMI RN HDAC inhibitors: a 2013-2017 patent survey.Expert Opin Ther Pat. 2018 Apr 19:1-17. DM0VBMI RU https://www.ncbi.nlm.nih.gov/pubmed/29671355 DM0VBMI DI DM0VBMI DM0VBMI DN PMID29671355-Compound-56 DM0VBMI MI TT4YWTO DM0VBMI MN Histone deacetylase 3 (HDAC3) DM0VBMI MT DTT DM0VBMI MA Inhibitor DM0VBMI RN HDAC inhibitors: a 2013-2017 patent survey.Expert Opin Ther Pat. 2018 Apr 19:1-17. DM0VBMI RU https://www.ncbi.nlm.nih.gov/pubmed/29671355 DM0VBMI DI DM0VBMI DM0VBMI DN PMID29671355-Compound-56 DM0VBMI MI TTTQGH8 DM0VBMI MN Histone deacetylase 4 (HDAC4) DM0VBMI MT DTT DM0VBMI MA Inhibitor DM0VBMI RN HDAC inhibitors: a 2013-2017 patent survey.Expert Opin Ther Pat. 2018 Apr 19:1-17. DM0VBMI RU https://www.ncbi.nlm.nih.gov/pubmed/29671355 DM0VBMI DI DM0VBMI DM0VBMI DN PMID29671355-Compound-56 DM0VBMI MI TT5ZKDI DM0VBMI MN Histone deacetylase 6 (HDAC6) DM0VBMI MT DTT DM0VBMI MA Inhibitor DM0VBMI RN HDAC inhibitors: a 2013-2017 patent survey.Expert Opin Ther Pat. 2018 Apr 19:1-17. DM0VBMI RU https://www.ncbi.nlm.nih.gov/pubmed/29671355 DM0VBMI DI DM0VBMI DM0VBMI DN PMID29671355-Compound-56 DM0VBMI MI TTMUEK1 DM0VBMI MN Histone deacetylase 7 (HDAC7) DM0VBMI MT DTT DM0VBMI MA Inhibitor DM0VBMI RN HDAC inhibitors: a 2013-2017 patent survey.Expert Opin Ther Pat. 2018 Apr 19:1-17. DM0VBMI RU https://www.ncbi.nlm.nih.gov/pubmed/29671355 DM0VBMI DI DM0VBMI DM0VBMI DN PMID29671355-Compound-56 DM0VBMI MI TTT6LFV DM0VBMI MN Histone deacetylase 8 (HDAC8) DM0VBMI MT DTT DM0VBMI MA Inhibitor DM0VBMI RN HDAC inhibitors: a 2013-2017 patent survey.Expert Opin Ther Pat. 2018 Apr 19:1-17. DM0VBMI RU https://www.ncbi.nlm.nih.gov/pubmed/29671355 DM57N3Y DI DM57N3Y DM57N3Y DN PMID29671355-Compound-57 DM57N3Y MI TT6R7JZ DM57N3Y MN Histone deacetylase 1 (HDAC1) DM57N3Y MT DTT DM57N3Y MA Inhibitor DM57N3Y RN HDAC inhibitors: a 2013-2017 patent survey.Expert Opin Ther Pat. 2018 Apr 19:1-17. DM57N3Y RU https://www.ncbi.nlm.nih.gov/pubmed/29671355 DM57N3Y DI DM57N3Y DM57N3Y DN PMID29671355-Compound-57 DM57N3Y MI TT4YWTO DM57N3Y MN Histone deacetylase 3 (HDAC3) DM57N3Y MT DTT DM57N3Y MA Inhibitor DM57N3Y RN HDAC inhibitors: a 2013-2017 patent survey.Expert Opin Ther Pat. 2018 Apr 19:1-17. DM57N3Y RU https://www.ncbi.nlm.nih.gov/pubmed/29671355 DM2F0CQ DI DM2F0CQ DM2F0CQ DN PMID29671355-Compound-59 DM2F0CQ MI TT6R7JZ DM2F0CQ MN Histone deacetylase 1 (HDAC1) DM2F0CQ MT DTT DM2F0CQ MA Inhibitor DM2F0CQ RN HDAC inhibitors: a 2013-2017 patent survey.Expert Opin Ther Pat. 2018 Apr 19:1-17. DM2F0CQ RU https://www.ncbi.nlm.nih.gov/pubmed/29671355 DM2F0CQ DI DM2F0CQ DM2F0CQ DN PMID29671355-Compound-59 DM2F0CQ MI TTSHTOI DM2F0CQ MN Histone deacetylase 2 (HDAC2) DM2F0CQ MT DTT DM2F0CQ MA Inhibitor DM2F0CQ RN HDAC inhibitors: a 2013-2017 patent survey.Expert Opin Ther Pat. 2018 Apr 19:1-17. DM2F0CQ RU https://www.ncbi.nlm.nih.gov/pubmed/29671355 DM2F0CQ DI DM2F0CQ DM2F0CQ DN PMID29671355-Compound-59 DM2F0CQ MI TT4YWTO DM2F0CQ MN Histone deacetylase 3 (HDAC3) DM2F0CQ MT DTT DM2F0CQ MA Inhibitor DM2F0CQ RN HDAC inhibitors: a 2013-2017 patent survey.Expert Opin Ther Pat. 2018 Apr 19:1-17. DM2F0CQ RU https://www.ncbi.nlm.nih.gov/pubmed/29671355 DMXH1G3 DI DMXH1G3 DMXH1G3 DN PMID29671355-Compound-61 DMXH1G3 MI TT6R7JZ DMXH1G3 MN Histone deacetylase 1 (HDAC1) DMXH1G3 MT DTT DMXH1G3 MA Inhibitor DMXH1G3 RN HDAC inhibitors: a 2013-2017 patent survey.Expert Opin Ther Pat. 2018 Apr 19:1-17. DMXH1G3 RU https://www.ncbi.nlm.nih.gov/pubmed/29671355 DMXH1G3 DI DMXH1G3 DMXH1G3 DN PMID29671355-Compound-61 DMXH1G3 MI TTSHTOI DMXH1G3 MN Histone deacetylase 2 (HDAC2) DMXH1G3 MT DTT DMXH1G3 MA Inhibitor DMXH1G3 RN HDAC inhibitors: a 2013-2017 patent survey.Expert Opin Ther Pat. 2018 Apr 19:1-17. DMXH1G3 RU https://www.ncbi.nlm.nih.gov/pubmed/29671355 DMXH1G3 DI DMXH1G3 DMXH1G3 DN PMID29671355-Compound-61 DMXH1G3 MI TT4YWTO DMXH1G3 MN Histone deacetylase 3 (HDAC3) DMXH1G3 MT DTT DMXH1G3 MA Inhibitor DMXH1G3 RN HDAC inhibitors: a 2013-2017 patent survey.Expert Opin Ther Pat. 2018 Apr 19:1-17. DMXH1G3 RU https://www.ncbi.nlm.nih.gov/pubmed/29671355 DMXH1G3 DI DMXH1G3 DMXH1G3 DN PMID29671355-Compound-61 DMXH1G3 MI TTTQGH8 DMXH1G3 MN Histone deacetylase 4 (HDAC4) DMXH1G3 MT DTT DMXH1G3 MA Inhibitor DMXH1G3 RN HDAC inhibitors: a 2013-2017 patent survey.Expert Opin Ther Pat. 2018 Apr 19:1-17. DMXH1G3 RU https://www.ncbi.nlm.nih.gov/pubmed/29671355 DMXH1G3 DI DMXH1G3 DMXH1G3 DN PMID29671355-Compound-61 DMXH1G3 MI TT5ZKDI DMXH1G3 MN Histone deacetylase 6 (HDAC6) DMXH1G3 MT DTT DMXH1G3 MA Inhibitor DMXH1G3 RN HDAC inhibitors: a 2013-2017 patent survey.Expert Opin Ther Pat. 2018 Apr 19:1-17. DMXH1G3 RU https://www.ncbi.nlm.nih.gov/pubmed/29671355 DMXH1G3 DI DMXH1G3 DMXH1G3 DN PMID29671355-Compound-61 DMXH1G3 MI TTT6LFV DMXH1G3 MN Histone deacetylase 8 (HDAC8) DMXH1G3 MT DTT DMXH1G3 MA Inhibitor DMXH1G3 RN HDAC inhibitors: a 2013-2017 patent survey.Expert Opin Ther Pat. 2018 Apr 19:1-17. DMXH1G3 RU https://www.ncbi.nlm.nih.gov/pubmed/29671355 DMWRS34 DI DMWRS34 DMWRS34 DN PMID29671355-Compound-62 DMWRS34 MI TT6R7JZ DMWRS34 MN Histone deacetylase 1 (HDAC1) DMWRS34 MT DTT DMWRS34 MA Inhibitor DMWRS34 RN HDAC inhibitors: a 2013-2017 patent survey.Expert Opin Ther Pat. 2018 Apr 19:1-17. DMWRS34 RU https://www.ncbi.nlm.nih.gov/pubmed/29671355 DMWRS34 DI DMWRS34 DMWRS34 DN PMID29671355-Compound-62 DMWRS34 MI TTYHPU6 DMWRS34 MN Histone deacetylase 10 (HDAC10) DMWRS34 MT DTT DMWRS34 MA Inhibitor DMWRS34 RN HDAC inhibitors: a 2013-2017 patent survey.Expert Opin Ther Pat. 2018 Apr 19:1-17. DMWRS34 RU https://www.ncbi.nlm.nih.gov/pubmed/29671355 DMWRS34 DI DMWRS34 DMWRS34 DN PMID29671355-Compound-62 DMWRS34 MI TT8K17W DMWRS34 MN Histone deacetylase 11 (HDAC11) DMWRS34 MT DTT DMWRS34 MA Inhibitor DMWRS34 RN HDAC inhibitors: a 2013-2017 patent survey.Expert Opin Ther Pat. 2018 Apr 19:1-17. DMWRS34 RU https://www.ncbi.nlm.nih.gov/pubmed/29671355 DMWRS34 DI DMWRS34 DMWRS34 DN PMID29671355-Compound-62 DMWRS34 MI TTSHTOI DMWRS34 MN Histone deacetylase 2 (HDAC2) DMWRS34 MT DTT DMWRS34 MA Inhibitor DMWRS34 RN HDAC inhibitors: a 2013-2017 patent survey.Expert Opin Ther Pat. 2018 Apr 19:1-17. DMWRS34 RU https://www.ncbi.nlm.nih.gov/pubmed/29671355 DMWRS34 DI DMWRS34 DMWRS34 DN PMID29671355-Compound-62 DMWRS34 MI TT4YWTO DMWRS34 MN Histone deacetylase 3 (HDAC3) DMWRS34 MT DTT DMWRS34 MA Inhibitor DMWRS34 RN HDAC inhibitors: a 2013-2017 patent survey.Expert Opin Ther Pat. 2018 Apr 19:1-17. DMWRS34 RU https://www.ncbi.nlm.nih.gov/pubmed/29671355 DMWRS34 DI DMWRS34 DMWRS34 DN PMID29671355-Compound-62 DMWRS34 MI TTTQGH8 DMWRS34 MN Histone deacetylase 4 (HDAC4) DMWRS34 MT DTT DMWRS34 MA Inhibitor DMWRS34 RN HDAC inhibitors: a 2013-2017 patent survey.Expert Opin Ther Pat. 2018 Apr 19:1-17. DMWRS34 RU https://www.ncbi.nlm.nih.gov/pubmed/29671355 DMWRS34 DI DMWRS34 DMWRS34 DN PMID29671355-Compound-62 DMWRS34 MI TTUELN5 DMWRS34 MN Histone deacetylase 5 (HDAC5) DMWRS34 MT DTT DMWRS34 MA Inhibitor DMWRS34 RN HDAC inhibitors: a 2013-2017 patent survey.Expert Opin Ther Pat. 2018 Apr 19:1-17. DMWRS34 RU https://www.ncbi.nlm.nih.gov/pubmed/29671355 DMWRS34 DI DMWRS34 DMWRS34 DN PMID29671355-Compound-62 DMWRS34 MI TT5ZKDI DMWRS34 MN Histone deacetylase 6 (HDAC6) DMWRS34 MT DTT DMWRS34 MA Inhibitor DMWRS34 RN HDAC inhibitors: a 2013-2017 patent survey.Expert Opin Ther Pat. 2018 Apr 19:1-17. DMWRS34 RU https://www.ncbi.nlm.nih.gov/pubmed/29671355 DMWRS34 DI DMWRS34 DMWRS34 DN PMID29671355-Compound-62 DMWRS34 MI TTMUEK1 DMWRS34 MN Histone deacetylase 7 (HDAC7) DMWRS34 MT DTT DMWRS34 MA Inhibitor DMWRS34 RN HDAC inhibitors: a 2013-2017 patent survey.Expert Opin Ther Pat. 2018 Apr 19:1-17. DMWRS34 RU https://www.ncbi.nlm.nih.gov/pubmed/29671355 DMWRS34 DI DMWRS34 DMWRS34 DN PMID29671355-Compound-62 DMWRS34 MI TTT6LFV DMWRS34 MN Histone deacetylase 8 (HDAC8) DMWRS34 MT DTT DMWRS34 MA Inhibitor DMWRS34 RN HDAC inhibitors: a 2013-2017 patent survey.Expert Opin Ther Pat. 2018 Apr 19:1-17. DMWRS34 RU https://www.ncbi.nlm.nih.gov/pubmed/29671355 DMWRS34 DI DMWRS34 DMWRS34 DN PMID29671355-Compound-62 DMWRS34 MI TT8M4E1 DMWRS34 MN Histone deacetylase 9 (HDAC9) DMWRS34 MT DTT DMWRS34 MA Inhibitor DMWRS34 RN HDAC inhibitors: a 2013-2017 patent survey.Expert Opin Ther Pat. 2018 Apr 19:1-17. DMWRS34 RU https://www.ncbi.nlm.nih.gov/pubmed/29671355 DMY3Q58 DI DMY3Q58 DMY3Q58 DN PMID29671355-Compound-65a DMY3Q58 MI TT6R7JZ DMY3Q58 MN Histone deacetylase 1 (HDAC1) DMY3Q58 MT DTT DMY3Q58 MA Inhibitor DMY3Q58 RN HDAC inhibitors: a 2013-2017 patent survey.Expert Opin Ther Pat. 2018 Apr 19:1-17. DMY3Q58 RU https://www.ncbi.nlm.nih.gov/pubmed/29671355 DMY3Q58 DI DMY3Q58 DMY3Q58 DN PMID29671355-Compound-65a DMY3Q58 MI TT5ZKDI DMY3Q58 MN Histone deacetylase 6 (HDAC6) DMY3Q58 MT DTT DMY3Q58 MA Inhibitor DMY3Q58 RN HDAC inhibitors: a 2013-2017 patent survey.Expert Opin Ther Pat. 2018 Apr 19:1-17. DMY3Q58 RU https://www.ncbi.nlm.nih.gov/pubmed/29671355 DM1RPL4 DI DM1RPL4 DM1RPL4 DN PMID29671355-Compound-67 DM1RPL4 MI TT6R7JZ DM1RPL4 MN Histone deacetylase 1 (HDAC1) DM1RPL4 MT DTT DM1RPL4 MA Inhibitor DM1RPL4 RN HDAC inhibitors: a 2013-2017 patent survey.Expert Opin Ther Pat. 2018 Apr 19:1-17. DM1RPL4 RU https://www.ncbi.nlm.nih.gov/pubmed/29671355 DM1RPL4 DI DM1RPL4 DM1RPL4 DN PMID29671355-Compound-67 DM1RPL4 MI TTSHTOI DM1RPL4 MN Histone deacetylase 2 (HDAC2) DM1RPL4 MT DTT DM1RPL4 MA Inhibitor DM1RPL4 RN HDAC inhibitors: a 2013-2017 patent survey.Expert Opin Ther Pat. 2018 Apr 19:1-17. DM1RPL4 RU https://www.ncbi.nlm.nih.gov/pubmed/29671355 DM1RPL4 DI DM1RPL4 DM1RPL4 DN PMID29671355-Compound-67 DM1RPL4 MI TT4YWTO DM1RPL4 MN Histone deacetylase 3 (HDAC3) DM1RPL4 MT DTT DM1RPL4 MA Inhibitor DM1RPL4 RN HDAC inhibitors: a 2013-2017 patent survey.Expert Opin Ther Pat. 2018 Apr 19:1-17. DM1RPL4 RU https://www.ncbi.nlm.nih.gov/pubmed/29671355 DM1RPL4 DI DM1RPL4 DM1RPL4 DN PMID29671355-Compound-67 DM1RPL4 MI TTTQGH8 DM1RPL4 MN Histone deacetylase 4 (HDAC4) DM1RPL4 MT DTT DM1RPL4 MA Inhibitor DM1RPL4 RN HDAC inhibitors: a 2013-2017 patent survey.Expert Opin Ther Pat. 2018 Apr 19:1-17. DM1RPL4 RU https://www.ncbi.nlm.nih.gov/pubmed/29671355 DM1RPL4 DI DM1RPL4 DM1RPL4 DN PMID29671355-Compound-67 DM1RPL4 MI TTUELN5 DM1RPL4 MN Histone deacetylase 5 (HDAC5) DM1RPL4 MT DTT DM1RPL4 MA Inhibitor DM1RPL4 RN HDAC inhibitors: a 2013-2017 patent survey.Expert Opin Ther Pat. 2018 Apr 19:1-17. DM1RPL4 RU https://www.ncbi.nlm.nih.gov/pubmed/29671355 DM1RPL4 DI DM1RPL4 DM1RPL4 DN PMID29671355-Compound-67 DM1RPL4 MI TT5ZKDI DM1RPL4 MN Histone deacetylase 6 (HDAC6) DM1RPL4 MT DTT DM1RPL4 MA Inhibitor DM1RPL4 RN HDAC inhibitors: a 2013-2017 patent survey.Expert Opin Ther Pat. 2018 Apr 19:1-17. DM1RPL4 RU https://www.ncbi.nlm.nih.gov/pubmed/29671355 DM1RPL4 DI DM1RPL4 DM1RPL4 DN PMID29671355-Compound-67 DM1RPL4 MI TTMUEK1 DM1RPL4 MN Histone deacetylase 7 (HDAC7) DM1RPL4 MT DTT DM1RPL4 MA Inhibitor DM1RPL4 RN HDAC inhibitors: a 2013-2017 patent survey.Expert Opin Ther Pat. 2018 Apr 19:1-17. DM1RPL4 RU https://www.ncbi.nlm.nih.gov/pubmed/29671355 DM1RPL4 DI DM1RPL4 DM1RPL4 DN PMID29671355-Compound-67 DM1RPL4 MI TTT6LFV DM1RPL4 MN Histone deacetylase 8 (HDAC8) DM1RPL4 MT DTT DM1RPL4 MA Inhibitor DM1RPL4 RN HDAC inhibitors: a 2013-2017 patent survey.Expert Opin Ther Pat. 2018 Apr 19:1-17. DM1RPL4 RU https://www.ncbi.nlm.nih.gov/pubmed/29671355 DMLGBR6 DI DMLGBR6 DMLGBR6 DN PMID29671355-Compound-68b DMLGBR6 MI TTTQGH8 DMLGBR6 MN Histone deacetylase 4 (HDAC4) DMLGBR6 MT DTT DMLGBR6 MA Inhibitor DMLGBR6 RN HDAC inhibitors: a 2013-2017 patent survey.Expert Opin Ther Pat. 2018 Apr 19:1-17. DMLGBR6 RU https://www.ncbi.nlm.nih.gov/pubmed/29671355 DMLGBR6 DI DMLGBR6 DMLGBR6 DN PMID29671355-Compound-68b DMLGBR6 MI TTT6LFV DMLGBR6 MN Histone deacetylase 8 (HDAC8) DMLGBR6 MT DTT DMLGBR6 MA Inhibitor DMLGBR6 RN HDAC inhibitors: a 2013-2017 patent survey.Expert Opin Ther Pat. 2018 Apr 19:1-17. DMLGBR6 RU https://www.ncbi.nlm.nih.gov/pubmed/29671355 DMU61XP DI DMU61XP DMU61XP DN PMID29671355-Compound-69 DMU61XP MI TTBH0VX DMU61XP MN Histone deacetylase (HDAC) DMU61XP MT DTT DMU61XP MA Inhibitor DMU61XP RN HDAC inhibitors: a 2013-2017 patent survey.Expert Opin Ther Pat. 2018 Apr 19:1-17. DMU61XP RU https://www.ncbi.nlm.nih.gov/pubmed/29671355 DM394WH DI DM394WH DM394WH DN PMID29671355-Compound-70 DM394WH MI TTTQGH8 DM394WH MN Histone deacetylase 4 (HDAC4) DM394WH MT DTT DM394WH MA Inhibitor DM394WH RN HDAC inhibitors: a 2013-2017 patent survey.Expert Opin Ther Pat. 2018 Apr 19:1-17. DM394WH RU https://www.ncbi.nlm.nih.gov/pubmed/29671355 DMUAC1T DI DMUAC1T DMUAC1T DN PMID29671355-Compound-71a DMUAC1T MI TTTQGH8 DMUAC1T MN Histone deacetylase 4 (HDAC4) DMUAC1T MT DTT DMUAC1T MA Inhibitor DMUAC1T RN HDAC inhibitors: a 2013-2017 patent survey.Expert Opin Ther Pat. 2018 Apr 19:1-17. DMUAC1T RU https://www.ncbi.nlm.nih.gov/pubmed/29671355 DM8VG4Q DI DM8VG4Q DM8VG4Q DN PMID29671355-Compound-71b DM8VG4Q MI TTTQGH8 DM8VG4Q MN Histone deacetylase 4 (HDAC4) DM8VG4Q MT DTT DM8VG4Q MA Inhibitor DM8VG4Q RN HDAC inhibitors: a 2013-2017 patent survey.Expert Opin Ther Pat. 2018 Apr 19:1-17. DM8VG4Q RU https://www.ncbi.nlm.nih.gov/pubmed/29671355 DMICDV6 DI DMICDV6 DMICDV6 DN PMID29671355-Compound-72a DMICDV6 MI TTTQGH8 DMICDV6 MN Histone deacetylase 4 (HDAC4) DMICDV6 MT DTT DMICDV6 MA Inhibitor DMICDV6 RN HDAC inhibitors: a 2013-2017 patent survey.Expert Opin Ther Pat. 2018 Apr 19:1-17. DMICDV6 RU https://www.ncbi.nlm.nih.gov/pubmed/29671355 DM08OV7 DI DM08OV7 DM08OV7 DN PMID29671355-Compound-72b DM08OV7 MI TTTQGH8 DM08OV7 MN Histone deacetylase 4 (HDAC4) DM08OV7 MT DTT DM08OV7 MA Inhibitor DM08OV7 RN HDAC inhibitors: a 2013-2017 patent survey.Expert Opin Ther Pat. 2018 Apr 19:1-17. DM08OV7 RU https://www.ncbi.nlm.nih.gov/pubmed/29671355 DMCNF36 DI DMCNF36 DMCNF36 DN PMID29671355-Compound-73 DMCNF36 MI TT6R7JZ DMCNF36 MN Histone deacetylase 1 (HDAC1) DMCNF36 MT DTT DMCNF36 MA Inhibitor DMCNF36 RN HDAC inhibitors: a 2013-2017 patent survey.Expert Opin Ther Pat. 2018 Apr 19:1-17. DMCNF36 RU https://www.ncbi.nlm.nih.gov/pubmed/29671355 DMCNF36 DI DMCNF36 DMCNF36 DN PMID29671355-Compound-73 DMCNF36 MI TT5ZKDI DMCNF36 MN Histone deacetylase 6 (HDAC6) DMCNF36 MT DTT DMCNF36 MA Inhibitor DMCNF36 RN HDAC inhibitors: a 2013-2017 patent survey.Expert Opin Ther Pat. 2018 Apr 19:1-17. DMCNF36 RU https://www.ncbi.nlm.nih.gov/pubmed/29671355 DMCNF36 DI DMCNF36 DMCNF36 DN PMID29671355-Compound-73 DMCNF36 MI TT8M4E1 DMCNF36 MN Histone deacetylase 9 (HDAC9) DMCNF36 MT DTT DMCNF36 MA Inhibitor DMCNF36 RN HDAC inhibitors: a 2013-2017 patent survey.Expert Opin Ther Pat. 2018 Apr 19:1-17. DMCNF36 RU https://www.ncbi.nlm.nih.gov/pubmed/29671355 DM49YTU DI DM49YTU DM49YTU DN PMID29671355-Compound-74 DM49YTU MI TTSHTOI DM49YTU MN Histone deacetylase 2 (HDAC2) DM49YTU MT DTT DM49YTU MA Inhibitor DM49YTU RN HDAC inhibitors: a 2013-2017 patent survey.Expert Opin Ther Pat. 2018 Apr 19:1-17. DM49YTU RU https://www.ncbi.nlm.nih.gov/pubmed/29671355 DM49YTU DI DM49YTU DM49YTU DN PMID29671355-Compound-74 DM49YTU MI TT5ZKDI DM49YTU MN Histone deacetylase 6 (HDAC6) DM49YTU MT DTT DM49YTU MA Inhibitor DM49YTU RN HDAC inhibitors: a 2013-2017 patent survey.Expert Opin Ther Pat. 2018 Apr 19:1-17. DM49YTU RU https://www.ncbi.nlm.nih.gov/pubmed/29671355 DM7YQJK DI DM7YQJK DM7YQJK DN PMID29671355-Compound-8 DM7YQJK MI TT6R7JZ DM7YQJK MN Histone deacetylase 1 (HDAC1) DM7YQJK MT DTT DM7YQJK MA Inhibitor DM7YQJK RN HDAC inhibitors: a 2013-2017 patent survey.Expert Opin Ther Pat. 2018 Apr 19:1-17. DM7YQJK RU https://www.ncbi.nlm.nih.gov/pubmed/29671355 DM7YQJK DI DM7YQJK DM7YQJK DN PMID29671355-Compound-8 DM7YQJK MI TTYHPU6 DM7YQJK MN Histone deacetylase 10 (HDAC10) DM7YQJK MT DTT DM7YQJK MA Inhibitor DM7YQJK RN HDAC inhibitors: a 2013-2017 patent survey.Expert Opin Ther Pat. 2018 Apr 19:1-17. DM7YQJK RU https://www.ncbi.nlm.nih.gov/pubmed/29671355 DM7YQJK DI DM7YQJK DM7YQJK DN PMID29671355-Compound-8 DM7YQJK MI TTSHTOI DM7YQJK MN Histone deacetylase 2 (HDAC2) DM7YQJK MT DTT DM7YQJK MA Inhibitor DM7YQJK RN HDAC inhibitors: a 2013-2017 patent survey.Expert Opin Ther Pat. 2018 Apr 19:1-17. DM7YQJK RU https://www.ncbi.nlm.nih.gov/pubmed/29671355 DM7YQJK DI DM7YQJK DM7YQJK DN PMID29671355-Compound-8 DM7YQJK MI TT4YWTO DM7YQJK MN Histone deacetylase 3 (HDAC3) DM7YQJK MT DTT DM7YQJK MA Inhibitor DM7YQJK RN HDAC inhibitors: a 2013-2017 patent survey.Expert Opin Ther Pat. 2018 Apr 19:1-17. DM7YQJK RU https://www.ncbi.nlm.nih.gov/pubmed/29671355 DM7YQJK DI DM7YQJK DM7YQJK DN PMID29671355-Compound-8 DM7YQJK MI TT5ZKDI DM7YQJK MN Histone deacetylase 6 (HDAC6) DM7YQJK MT DTT DM7YQJK MA Inhibitor DM7YQJK RN HDAC inhibitors: a 2013-2017 patent survey.Expert Opin Ther Pat. 2018 Apr 19:1-17. DM7YQJK RU https://www.ncbi.nlm.nih.gov/pubmed/29671355 DMXL96M DI DMXL96M DMXL96M DN PMID29671355-Compound-9 DMXL96M MI TT6R7JZ DMXL96M MN Histone deacetylase 1 (HDAC1) DMXL96M MT DTT DMXL96M MA Inhibitor DMXL96M RN HDAC inhibitors: a 2013-2017 patent survey.Expert Opin Ther Pat. 2018 Apr 19:1-17. DMXL96M RU https://www.ncbi.nlm.nih.gov/pubmed/29671355 DMXL96M DI DMXL96M DMXL96M DN PMID29671355-Compound-9 DMXL96M MI TTSHTOI DMXL96M MN Histone deacetylase 2 (HDAC2) DMXL96M MT DTT DMXL96M MA Inhibitor DMXL96M RN HDAC inhibitors: a 2013-2017 patent survey.Expert Opin Ther Pat. 2018 Apr 19:1-17. DMXL96M RU https://www.ncbi.nlm.nih.gov/pubmed/29671355 DMXL96M DI DMXL96M DMXL96M DN PMID29671355-Compound-9 DMXL96M MI TT4YWTO DMXL96M MN Histone deacetylase 3 (HDAC3) DMXL96M MT DTT DMXL96M MA Inhibitor DMXL96M RN HDAC inhibitors: a 2013-2017 patent survey.Expert Opin Ther Pat. 2018 Apr 19:1-17. DMXL96M RU https://www.ncbi.nlm.nih.gov/pubmed/29671355 DMXL96M DI DMXL96M DMXL96M DN PMID29671355-Compound-9 DMXL96M MI TT5ZKDI DMXL96M MN Histone deacetylase 6 (HDAC6) DMXL96M MT DTT DMXL96M MA Inhibitor DMXL96M RN HDAC inhibitors: a 2013-2017 patent survey.Expert Opin Ther Pat. 2018 Apr 19:1-17. DMXL96M RU https://www.ncbi.nlm.nih.gov/pubmed/29671355 DMZBHR9 DI DMZBHR9 DMZBHR9 DN PMID29757691-Compound-10 DMZBHR9 MI TT1RS9F DMZBHR9 MN Acetylcholinesterase (AChE) DMZBHR9 MT DTT DMZBHR9 MA Inhibitor DMZBHR9 RN A patent review of butyrylcholinesterase inhibitors and reactivators 2010-2017.Expert Opin Ther Pat. 2018 Jun;28(6):455-465. DMZBHR9 RU https://www.ncbi.nlm.nih.gov/pubmed/29757691 DMZBHR9 DI DMZBHR9 DMZBHR9 DN PMID29757691-Compound-10 DMZBHR9 MI TTEB0GD DMZBHR9 MN Cholinesterase (BCHE) DMZBHR9 MT DTT DMZBHR9 MA Inhibitor DMZBHR9 RN A patent review of butyrylcholinesterase inhibitors and reactivators 2010-2017.Expert Opin Ther Pat. 2018 Jun;28(6):455-465. DMZBHR9 RU https://www.ncbi.nlm.nih.gov/pubmed/29757691 DMEUC04 DI DMEUC04 DMEUC04 DN PMID29757691-Compound-2a DMEUC04 MI TT1RS9F DMEUC04 MN Acetylcholinesterase (AChE) DMEUC04 MT DTT DMEUC04 MA Inhibitor DMEUC04 RN A patent review of butyrylcholinesterase inhibitors and reactivators 2010-2017.Expert Opin Ther Pat. 2018 Jun;28(6):455-465. DMEUC04 RU https://www.ncbi.nlm.nih.gov/pubmed/29757691 DMEUC04 DI DMEUC04 DMEUC04 DN PMID29757691-Compound-2a DMEUC04 MI TTEB0GD DMEUC04 MN Cholinesterase (BCHE) DMEUC04 MT DTT DMEUC04 MA Inhibitor DMEUC04 RN A patent review of butyrylcholinesterase inhibitors and reactivators 2010-2017.Expert Opin Ther Pat. 2018 Jun;28(6):455-465. DMEUC04 RU https://www.ncbi.nlm.nih.gov/pubmed/29757691 DMBRQP1 DI DMBRQP1 DMBRQP1 DN PMID29757691-Compound-2a-i DMBRQP1 MI TT1RS9F DMBRQP1 MN Acetylcholinesterase (AChE) DMBRQP1 MT DTT DMBRQP1 MA Inhibitor DMBRQP1 RN A patent review of butyrylcholinesterase inhibitors and reactivators 2010-2017.Expert Opin Ther Pat. 2018 Jun;28(6):455-465. DMBRQP1 RU https://www.ncbi.nlm.nih.gov/pubmed/29757691 DMBRQP1 DI DMBRQP1 DMBRQP1 DN PMID29757691-Compound-2a-i DMBRQP1 MI TTEB0GD DMBRQP1 MN Cholinesterase (BCHE) DMBRQP1 MT DTT DMBRQP1 MA Inhibitor DMBRQP1 RN A patent review of butyrylcholinesterase inhibitors and reactivators 2010-2017.Expert Opin Ther Pat. 2018 Jun;28(6):455-465. DMBRQP1 RU https://www.ncbi.nlm.nih.gov/pubmed/29757691 DMFD9UZ DI DMFD9UZ DMFD9UZ DN PMID29757691-Compound-4 DMFD9UZ MI TT1RS9F DMFD9UZ MN Acetylcholinesterase (AChE) DMFD9UZ MT DTT DMFD9UZ MA Inhibitor DMFD9UZ RN A patent review of butyrylcholinesterase inhibitors and reactivators 2010-2017.Expert Opin Ther Pat. 2018 Jun;28(6):455-465. DMFD9UZ RU https://www.ncbi.nlm.nih.gov/pubmed/29757691 DMFD9UZ DI DMFD9UZ DMFD9UZ DN PMID29757691-Compound-4 DMFD9UZ MI TT3WG5C DMFD9UZ MN Monoamine oxidase type A (MAO-A) DMFD9UZ MT DTT DMFD9UZ MA Inhibitor DMFD9UZ RN A patent review of butyrylcholinesterase inhibitors and reactivators 2010-2017.Expert Opin Ther Pat. 2018 Jun;28(6):455-465. DMFD9UZ RU https://www.ncbi.nlm.nih.gov/pubmed/29757691 DMFD9UZ DI DMFD9UZ DMFD9UZ DN PMID29757691-Compound-4 DMFD9UZ MI TTGP7BY DMFD9UZ MN Monoamine oxidase type B (MAO-B) DMFD9UZ MT DTT DMFD9UZ MA Inhibitor DMFD9UZ RN A patent review of butyrylcholinesterase inhibitors and reactivators 2010-2017.Expert Opin Ther Pat. 2018 Jun;28(6):455-465. DMFD9UZ RU https://www.ncbi.nlm.nih.gov/pubmed/29757691 DM7TPBF DI DM7TPBF DM7TPBF DN PMID29757691-Compound-7 DM7TPBF MI TT1RS9F DM7TPBF MN Acetylcholinesterase (AChE) DM7TPBF MT DTT DM7TPBF MA Inhibitor DM7TPBF RN A patent review of butyrylcholinesterase inhibitors and reactivators 2010-2017.Expert Opin Ther Pat. 2018 Jun;28(6):455-465. DM7TPBF RU https://www.ncbi.nlm.nih.gov/pubmed/29757691 DM7TPBF DI DM7TPBF DM7TPBF DN PMID29757691-Compound-7 DM7TPBF MI TTEB0GD DM7TPBF MN Cholinesterase (BCHE) DM7TPBF MT DTT DM7TPBF MA Inhibitor DM7TPBF RN A patent review of butyrylcholinesterase inhibitors and reactivators 2010-2017.Expert Opin Ther Pat. 2018 Jun;28(6):455-465. DM7TPBF RU https://www.ncbi.nlm.nih.gov/pubmed/29757691 DM5IFBV DI DM5IFBV DM5IFBV DN PMID29757691-Compound-8a DM5IFBV MI TT1RS9F DM5IFBV MN Acetylcholinesterase (AChE) DM5IFBV MT DTT DM5IFBV MA Inhibitor DM5IFBV RN A patent review of butyrylcholinesterase inhibitors and reactivators 2010-2017.Expert Opin Ther Pat. 2018 Jun;28(6):455-465. DM5IFBV RU https://www.ncbi.nlm.nih.gov/pubmed/29757691 DM5IFBV DI DM5IFBV DM5IFBV DN PMID29757691-Compound-8a DM5IFBV MI TTEB0GD DM5IFBV MN Cholinesterase (BCHE) DM5IFBV MT DTT DM5IFBV MA Inhibitor DM5IFBV RN A patent review of butyrylcholinesterase inhibitors and reactivators 2010-2017.Expert Opin Ther Pat. 2018 Jun;28(6):455-465. DM5IFBV RU https://www.ncbi.nlm.nih.gov/pubmed/29757691 DMEOZKF DI DMEOZKF DMEOZKF DN PMID29757691-Compound-8b DMEOZKF MI TT1RS9F DMEOZKF MN Acetylcholinesterase (AChE) DMEOZKF MT DTT DMEOZKF MA Inhibitor DMEOZKF RN A patent review of butyrylcholinesterase inhibitors and reactivators 2010-2017.Expert Opin Ther Pat. 2018 Jun;28(6):455-465. DMEOZKF RU https://www.ncbi.nlm.nih.gov/pubmed/29757691 DMEOZKF DI DMEOZKF DMEOZKF DN PMID29757691-Compound-8b DMEOZKF MI TTEB0GD DMEOZKF MN Cholinesterase (BCHE) DMEOZKF MT DTT DMEOZKF MA Inhibitor DMEOZKF RN A patent review of butyrylcholinesterase inhibitors and reactivators 2010-2017.Expert Opin Ther Pat. 2018 Jun;28(6):455-465. DMEOZKF RU https://www.ncbi.nlm.nih.gov/pubmed/29757691 DMHL7SW DI DMHL7SW DMHL7SW DN PMID29757691-Compound-8c DMHL7SW MI TT1RS9F DMHL7SW MN Acetylcholinesterase (AChE) DMHL7SW MT DTT DMHL7SW MA Inhibitor DMHL7SW RN A patent review of butyrylcholinesterase inhibitors and reactivators 2010-2017.Expert Opin Ther Pat. 2018 Jun;28(6):455-465. DMHL7SW RU https://www.ncbi.nlm.nih.gov/pubmed/29757691 DMHL7SW DI DMHL7SW DMHL7SW DN PMID29757691-Compound-8c DMHL7SW MI TTEB0GD DMHL7SW MN Cholinesterase (BCHE) DMHL7SW MT DTT DMHL7SW MA Inhibitor DMHL7SW RN A patent review of butyrylcholinesterase inhibitors and reactivators 2010-2017.Expert Opin Ther Pat. 2018 Jun;28(6):455-465. DMHL7SW RU https://www.ncbi.nlm.nih.gov/pubmed/29757691 DM6PDEH DI DM6PDEH DM6PDEH DN PMID29757691-Compound-8d DM6PDEH MI TT1RS9F DM6PDEH MN Acetylcholinesterase (AChE) DM6PDEH MT DTT DM6PDEH MA Inhibitor DM6PDEH RN A patent review of butyrylcholinesterase inhibitors and reactivators 2010-2017.Expert Opin Ther Pat. 2018 Jun;28(6):455-465. DM6PDEH RU https://www.ncbi.nlm.nih.gov/pubmed/29757691 DM6PDEH DI DM6PDEH DM6PDEH DN PMID29757691-Compound-8d DM6PDEH MI TTEB0GD DM6PDEH MN Cholinesterase (BCHE) DM6PDEH MT DTT DM6PDEH MA Inhibitor DM6PDEH RN A patent review of butyrylcholinesterase inhibitors and reactivators 2010-2017.Expert Opin Ther Pat. 2018 Jun;28(6):455-465. DM6PDEH RU https://www.ncbi.nlm.nih.gov/pubmed/29757691 DMCZ3SH DI DMCZ3SH DMCZ3SH DN PMID29865878-Compound-38 DMCZ3SH MI TTSJMN8 DMCZ3SH MN Immunoproteasome complex (IP) DMCZ3SH MT DTT DMCZ3SH MA Inhibitor DMCZ3SH RN A patent review of immunoproteasome inhibitors.Expert Opin Ther Pat. 2018 Jul;28(7):517-540. DMCZ3SH RU https://www.ncbi.nlm.nih.gov/pubmed/29865878 DMSCWZF DI DMSCWZF DMSCWZF DN PMID29865878-Compound-39 DMSCWZF MI TTSJMN8 DMSCWZF MN Immunoproteasome complex (IP) DMSCWZF MT DTT DMSCWZF MA Inhibitor DMSCWZF RN A patent review of immunoproteasome inhibitors.Expert Opin Ther Pat. 2018 Jul;28(7):517-540. DMSCWZF RU https://www.ncbi.nlm.nih.gov/pubmed/29865878 DMGXUNA DI DMGXUNA DMGXUNA DN PMID29865878-Compound-40 DMGXUNA MI TTSJMN8 DMGXUNA MN Immunoproteasome complex (IP) DMGXUNA MT DTT DMGXUNA MA Inhibitor DMGXUNA RN A patent review of immunoproteasome inhibitors.Expert Opin Ther Pat. 2018 Jul;28(7):517-540. DMGXUNA RU https://www.ncbi.nlm.nih.gov/pubmed/29865878 DMSAO52 DI DMSAO52 DMSAO52 DN PMID29865878-Compound-41 DMSAO52 MI TTSJMN8 DMSAO52 MN Immunoproteasome complex (IP) DMSAO52 MT DTT DMSAO52 MA Inhibitor DMSAO52 RN A patent review of immunoproteasome inhibitors.Expert Opin Ther Pat. 2018 Jul;28(7):517-540. DMSAO52 RU https://www.ncbi.nlm.nih.gov/pubmed/29865878 DMY2PTU DI DMY2PTU DMY2PTU DN PMID29865878-Compound-42 DMY2PTU MI TTSJMN8 DMY2PTU MN Immunoproteasome complex (IP) DMY2PTU MT DTT DMY2PTU MA Inhibitor DMY2PTU RN A patent review of immunoproteasome inhibitors.Expert Opin Ther Pat. 2018 Jul;28(7):517-540. DMY2PTU RU https://www.ncbi.nlm.nih.gov/pubmed/29865878 DMQUE6D DI DMQUE6D DMQUE6D DN PMID29865878-Compound-43 DMQUE6D MI TT68GPI DMQUE6D MN Proteasome beta-5 (PS beta-5) DMQUE6D MT DTT DMQUE6D MA Inhibitor DMQUE6D RN A patent review of immunoproteasome inhibitors.Expert Opin Ther Pat. 2018 Jul;28(7):517-540. DMQUE6D RU https://www.ncbi.nlm.nih.gov/pubmed/29865878 DMQUE6D DI DMQUE6D DMQUE6D DN PMID29865878-Compound-43 DMQUE6D MI TTEAD9J DMQUE6D MN Proteasome beta-8 (PS beta-8) DMQUE6D MT DTT DMQUE6D MA Inhibitor DMQUE6D RN A patent review of immunoproteasome inhibitors.Expert Opin Ther Pat. 2018 Jul;28(7):517-540. DMQUE6D RU https://www.ncbi.nlm.nih.gov/pubmed/29865878 DMRTQ4I DI DMRTQ4I DMRTQ4I DN PMID29865878-Compound-44 DMRTQ4I MI TT68GPI DMRTQ4I MN Proteasome beta-5 (PS beta-5) DMRTQ4I MT DTT DMRTQ4I MA Inhibitor DMRTQ4I RN A patent review of immunoproteasome inhibitors.Expert Opin Ther Pat. 2018 Jul;28(7):517-540. DMRTQ4I RU https://www.ncbi.nlm.nih.gov/pubmed/29865878 DMRTQ4I DI DMRTQ4I DMRTQ4I DN PMID29865878-Compound-44 DMRTQ4I MI TTEAD9J DMRTQ4I MN Proteasome beta-8 (PS beta-8) DMRTQ4I MT DTT DMRTQ4I MA Inhibitor DMRTQ4I RN A patent review of immunoproteasome inhibitors.Expert Opin Ther Pat. 2018 Jul;28(7):517-540. DMRTQ4I RU https://www.ncbi.nlm.nih.gov/pubmed/29865878 DM462XZ DI DM462XZ DM462XZ DN PMID29865878-Compound-45 DM462XZ MI TTSJMN8 DM462XZ MN Immunoproteasome complex (IP) DM462XZ MT DTT DM462XZ MA Inhibitor DM462XZ RN A patent review of immunoproteasome inhibitors.Expert Opin Ther Pat. 2018 Jul;28(7):517-540. DM462XZ RU https://www.ncbi.nlm.nih.gov/pubmed/29865878 DMP3MXK DI DMP3MXK DMP3MXK DN PMID29865878-Compound-46 DMP3MXK MI TT8EPLT DMP3MXK MN Proteasome beta-1 (PS beta-1) DMP3MXK MT DTT DMP3MXK MA Inhibitor DMP3MXK RN A patent review of immunoproteasome inhibitors.Expert Opin Ther Pat. 2018 Jul;28(7):517-540. DMP3MXK RU https://www.ncbi.nlm.nih.gov/pubmed/29865878 DMP3MXK DI DMP3MXK DMP3MXK DN PMID29865878-Compound-46 DMP3MXK MI TT68GPI DMP3MXK MN Proteasome beta-5 (PS beta-5) DMP3MXK MT DTT DMP3MXK MA Inhibitor DMP3MXK RN A patent review of immunoproteasome inhibitors.Expert Opin Ther Pat. 2018 Jul;28(7):517-540. DMP3MXK RU https://www.ncbi.nlm.nih.gov/pubmed/29865878 DMP3MXK DI DMP3MXK DMP3MXK DN PMID29865878-Compound-46 DMP3MXK MI TTEAD9J DMP3MXK MN Proteasome beta-8 (PS beta-8) DMP3MXK MT DTT DMP3MXK MA Inhibitor DMP3MXK RN A patent review of immunoproteasome inhibitors.Expert Opin Ther Pat. 2018 Jul;28(7):517-540. DMP3MXK RU https://www.ncbi.nlm.nih.gov/pubmed/29865878 DMP3MXK DI DMP3MXK DMP3MXK DN PMID29865878-Compound-46 DMP3MXK MI TTOUSTQ DMP3MXK MN Proteasome beta-9 (PS beta-9) DMP3MXK MT DTT DMP3MXK MA Inhibitor DMP3MXK RN A patent review of immunoproteasome inhibitors.Expert Opin Ther Pat. 2018 Jul;28(7):517-540. DMP3MXK RU https://www.ncbi.nlm.nih.gov/pubmed/29865878 DMX31I2 DI DMX31I2 DMX31I2 DN PMID29865878-Compound-47 DMX31I2 MI TTSJMN8 DMX31I2 MN Immunoproteasome complex (IP) DMX31I2 MT DTT DMX31I2 MA Inhibitor DMX31I2 RN A patent review of immunoproteasome inhibitors.Expert Opin Ther Pat. 2018 Jul;28(7):517-540. DMX31I2 RU https://www.ncbi.nlm.nih.gov/pubmed/29865878 DMVQTR2 DI DMVQTR2 DMVQTR2 DN PMID29865878-Compound-48 DMVQTR2 MI TT8EPLT DMVQTR2 MN Proteasome beta-1 (PS beta-1) DMVQTR2 MT DTT DMVQTR2 MA Inhibitor DMVQTR2 RN A patent review of immunoproteasome inhibitors.Expert Opin Ther Pat. 2018 Jul;28(7):517-540. DMVQTR2 RU https://www.ncbi.nlm.nih.gov/pubmed/29865878 DMVQTR2 DI DMVQTR2 DMVQTR2 DN PMID29865878-Compound-48 DMVQTR2 MI TT68GPI DMVQTR2 MN Proteasome beta-5 (PS beta-5) DMVQTR2 MT DTT DMVQTR2 MA Inhibitor DMVQTR2 RN A patent review of immunoproteasome inhibitors.Expert Opin Ther Pat. 2018 Jul;28(7):517-540. DMVQTR2 RU https://www.ncbi.nlm.nih.gov/pubmed/29865878 DMVQTR2 DI DMVQTR2 DMVQTR2 DN PMID29865878-Compound-48 DMVQTR2 MI TTEAD9J DMVQTR2 MN Proteasome beta-8 (PS beta-8) DMVQTR2 MT DTT DMVQTR2 MA Inhibitor DMVQTR2 RN A patent review of immunoproteasome inhibitors.Expert Opin Ther Pat. 2018 Jul;28(7):517-540. DMVQTR2 RU https://www.ncbi.nlm.nih.gov/pubmed/29865878 DMVQTR2 DI DMVQTR2 DMVQTR2 DN PMID29865878-Compound-48 DMVQTR2 MI TTOUSTQ DMVQTR2 MN Proteasome beta-9 (PS beta-9) DMVQTR2 MT DTT DMVQTR2 MA Inhibitor DMVQTR2 RN A patent review of immunoproteasome inhibitors.Expert Opin Ther Pat. 2018 Jul;28(7):517-540. DMVQTR2 RU https://www.ncbi.nlm.nih.gov/pubmed/29865878 DMK0GTV DI DMK0GTV DMK0GTV DN PMID29865878-Compound-49 DMK0GTV MI TT8EPLT DMK0GTV MN Proteasome beta-1 (PS beta-1) DMK0GTV MT DTT DMK0GTV MA Inhibitor DMK0GTV RN A patent review of immunoproteasome inhibitors.Expert Opin Ther Pat. 2018 Jul;28(7):517-540. DMK0GTV RU https://www.ncbi.nlm.nih.gov/pubmed/29865878 DMK0GTV DI DMK0GTV DMK0GTV DN PMID29865878-Compound-49 DMK0GTV MI TT68GPI DMK0GTV MN Proteasome beta-5 (PS beta-5) DMK0GTV MT DTT DMK0GTV MA Inhibitor DMK0GTV RN A patent review of immunoproteasome inhibitors.Expert Opin Ther Pat. 2018 Jul;28(7):517-540. DMK0GTV RU https://www.ncbi.nlm.nih.gov/pubmed/29865878 DMK0GTV DI DMK0GTV DMK0GTV DN PMID29865878-Compound-49 DMK0GTV MI TTEAD9J DMK0GTV MN Proteasome beta-8 (PS beta-8) DMK0GTV MT DTT DMK0GTV MA Inhibitor DMK0GTV RN A patent review of immunoproteasome inhibitors.Expert Opin Ther Pat. 2018 Jul;28(7):517-540. DMK0GTV RU https://www.ncbi.nlm.nih.gov/pubmed/29865878 DMK0GTV DI DMK0GTV DMK0GTV DN PMID29865878-Compound-49 DMK0GTV MI TTOUSTQ DMK0GTV MN Proteasome beta-9 (PS beta-9) DMK0GTV MT DTT DMK0GTV MA Inhibitor DMK0GTV RN A patent review of immunoproteasome inhibitors.Expert Opin Ther Pat. 2018 Jul;28(7):517-540. DMK0GTV RU https://www.ncbi.nlm.nih.gov/pubmed/29865878 DMZ8BJX DI DMZ8BJX DMZ8BJX DN PMID29865878-Compound-50 DMZ8BJX MI TTSJMN8 DMZ8BJX MN Immunoproteasome complex (IP) DMZ8BJX MT DTT DMZ8BJX MA Inhibitor DMZ8BJX RN A patent review of immunoproteasome inhibitors.Expert Opin Ther Pat. 2018 Jul;28(7):517-540. DMZ8BJX RU https://www.ncbi.nlm.nih.gov/pubmed/29865878 DM0LXT2 DI DM0LXT2 DM0LXT2 DN PMID29865878-Compound-51 DM0LXT2 MI TT8EPLT DM0LXT2 MN Proteasome beta-1 (PS beta-1) DM0LXT2 MT DTT DM0LXT2 MA Inhibitor DM0LXT2 RN A patent review of immunoproteasome inhibitors.Expert Opin Ther Pat. 2018 Jul;28(7):517-540. DM0LXT2 RU https://www.ncbi.nlm.nih.gov/pubmed/29865878 DM0LXT2 DI DM0LXT2 DM0LXT2 DN PMID29865878-Compound-51 DM0LXT2 MI TT68GPI DM0LXT2 MN Proteasome beta-5 (PS beta-5) DM0LXT2 MT DTT DM0LXT2 MA Inhibitor DM0LXT2 RN A patent review of immunoproteasome inhibitors.Expert Opin Ther Pat. 2018 Jul;28(7):517-540. DM0LXT2 RU https://www.ncbi.nlm.nih.gov/pubmed/29865878 DM0LXT2 DI DM0LXT2 DM0LXT2 DN PMID29865878-Compound-51 DM0LXT2 MI TTEAD9J DM0LXT2 MN Proteasome beta-8 (PS beta-8) DM0LXT2 MT DTT DM0LXT2 MA Inhibitor DM0LXT2 RN A patent review of immunoproteasome inhibitors.Expert Opin Ther Pat. 2018 Jul;28(7):517-540. DM0LXT2 RU https://www.ncbi.nlm.nih.gov/pubmed/29865878 DM0LXT2 DI DM0LXT2 DM0LXT2 DN PMID29865878-Compound-51 DM0LXT2 MI TTOUSTQ DM0LXT2 MN Proteasome beta-9 (PS beta-9) DM0LXT2 MT DTT DM0LXT2 MA Inhibitor DM0LXT2 RN A patent review of immunoproteasome inhibitors.Expert Opin Ther Pat. 2018 Jul;28(7):517-540. DM0LXT2 RU https://www.ncbi.nlm.nih.gov/pubmed/29865878 DM47M2U DI DM47M2U DM47M2U DN PMID29865878-Compound-52 DM47M2U MI TTSJMN8 DM47M2U MN Immunoproteasome complex (IP) DM47M2U MT DTT DM47M2U MA Inhibitor DM47M2U RN A patent review of immunoproteasome inhibitors.Expert Opin Ther Pat. 2018 Jul;28(7):517-540. DM47M2U RU https://www.ncbi.nlm.nih.gov/pubmed/29865878 DM6JV1W DI DM6JV1W DM6JV1W DN PMID29865878-Compound-53 DM6JV1W MI TT8EPLT DM6JV1W MN Proteasome beta-1 (PS beta-1) DM6JV1W MT DTT DM6JV1W MA Inhibitor DM6JV1W RN A patent review of immunoproteasome inhibitors.Expert Opin Ther Pat. 2018 Jul;28(7):517-540. DM6JV1W RU https://www.ncbi.nlm.nih.gov/pubmed/29865878 DM6JV1W DI DM6JV1W DM6JV1W DN PMID29865878-Compound-53 DM6JV1W MI TT68GPI DM6JV1W MN Proteasome beta-5 (PS beta-5) DM6JV1W MT DTT DM6JV1W MA Inhibitor DM6JV1W RN A patent review of immunoproteasome inhibitors.Expert Opin Ther Pat. 2018 Jul;28(7):517-540. DM6JV1W RU https://www.ncbi.nlm.nih.gov/pubmed/29865878 DM6JV1W DI DM6JV1W DM6JV1W DN PMID29865878-Compound-53 DM6JV1W MI TTEAD9J DM6JV1W MN Proteasome beta-8 (PS beta-8) DM6JV1W MT DTT DM6JV1W MA Inhibitor DM6JV1W RN A patent review of immunoproteasome inhibitors.Expert Opin Ther Pat. 2018 Jul;28(7):517-540. DM6JV1W RU https://www.ncbi.nlm.nih.gov/pubmed/29865878 DM6JV1W DI DM6JV1W DM6JV1W DN PMID29865878-Compound-53 DM6JV1W MI TTOUSTQ DM6JV1W MN Proteasome beta-9 (PS beta-9) DM6JV1W MT DTT DM6JV1W MA Inhibitor DM6JV1W RN A patent review of immunoproteasome inhibitors.Expert Opin Ther Pat. 2018 Jul;28(7):517-540. DM6JV1W RU https://www.ncbi.nlm.nih.gov/pubmed/29865878 DMED71P DI DMED71P DMED71P DN PMID29865878-Compound-54 DMED71P MI TTSJMN8 DMED71P MN Immunoproteasome complex (IP) DMED71P MT DTT DMED71P MA Inhibitor DMED71P RN A patent review of immunoproteasome inhibitors.Expert Opin Ther Pat. 2018 Jul;28(7):517-540. DMED71P RU https://www.ncbi.nlm.nih.gov/pubmed/29865878 DMY52ZB DI DMY52ZB DMY52ZB DN PMID29865878-Compound-55 DMY52ZB MI TT8EPLT DMY52ZB MN Proteasome beta-1 (PS beta-1) DMY52ZB MT DTT DMY52ZB MA Inhibitor DMY52ZB RN A patent review of immunoproteasome inhibitors.Expert Opin Ther Pat. 2018 Jul;28(7):517-540. DMY52ZB RU https://www.ncbi.nlm.nih.gov/pubmed/29865878 DMY52ZB DI DMY52ZB DMY52ZB DN PMID29865878-Compound-55 DMY52ZB MI TT68GPI DMY52ZB MN Proteasome beta-5 (PS beta-5) DMY52ZB MT DTT DMY52ZB MA Inhibitor DMY52ZB RN A patent review of immunoproteasome inhibitors.Expert Opin Ther Pat. 2018 Jul;28(7):517-540. DMY52ZB RU https://www.ncbi.nlm.nih.gov/pubmed/29865878 DMY52ZB DI DMY52ZB DMY52ZB DN PMID29865878-Compound-55 DMY52ZB MI TTEAD9J DMY52ZB MN Proteasome beta-8 (PS beta-8) DMY52ZB MT DTT DMY52ZB MA Inhibitor DMY52ZB RN A patent review of immunoproteasome inhibitors.Expert Opin Ther Pat. 2018 Jul;28(7):517-540. DMY52ZB RU https://www.ncbi.nlm.nih.gov/pubmed/29865878 DMY52ZB DI DMY52ZB DMY52ZB DN PMID29865878-Compound-55 DMY52ZB MI TTOUSTQ DMY52ZB MN Proteasome beta-9 (PS beta-9) DMY52ZB MT DTT DMY52ZB MA Inhibitor DMY52ZB RN A patent review of immunoproteasome inhibitors.Expert Opin Ther Pat. 2018 Jul;28(7):517-540. DMY52ZB RU https://www.ncbi.nlm.nih.gov/pubmed/29865878 DM45QW1 DI DM45QW1 DM45QW1 DN PMID29865878-Compound-56 DM45QW1 MI TTSJMN8 DM45QW1 MN Immunoproteasome complex (IP) DM45QW1 MT DTT DM45QW1 MA Inhibitor DM45QW1 RN A patent review of immunoproteasome inhibitors.Expert Opin Ther Pat. 2018 Jul;28(7):517-540. DM45QW1 RU https://www.ncbi.nlm.nih.gov/pubmed/29865878 DM3VQ1Y DI DM3VQ1Y DM3VQ1Y DN PMID29865878-Compound-57 DM3VQ1Y MI TTEAD9J DM3VQ1Y MN Proteasome beta-8 (PS beta-8) DM3VQ1Y MT DTT DM3VQ1Y MA Inhibitor DM3VQ1Y RN A patent review of immunoproteasome inhibitors.Expert Opin Ther Pat. 2018 Jul;28(7):517-540. DM3VQ1Y RU https://www.ncbi.nlm.nih.gov/pubmed/29865878 DMO108N DI DMO108N DMO108N DN PMID29865878-Compound-58 DMO108N MI TTEAD9J DMO108N MN Proteasome beta-8 (PS beta-8) DMO108N MT DTT DMO108N MA Inhibitor DMO108N RN A patent review of immunoproteasome inhibitors.Expert Opin Ther Pat. 2018 Jul;28(7):517-540. DMO108N RU https://www.ncbi.nlm.nih.gov/pubmed/29865878 DMM73VG DI DMM73VG DMM73VG DN PMID29865878-Compound-59 DMM73VG MI TTEAD9J DMM73VG MN Proteasome beta-8 (PS beta-8) DMM73VG MT DTT DMM73VG MA Inhibitor DMM73VG RN A patent review of immunoproteasome inhibitors.Expert Opin Ther Pat. 2018 Jul;28(7):517-540. DMM73VG RU https://www.ncbi.nlm.nih.gov/pubmed/29865878 DMPQX8R DI DMPQX8R DMPQX8R DN PMID29865878-Compound-60 DMPQX8R MI TTSJMN8 DMPQX8R MN Immunoproteasome complex (IP) DMPQX8R MT DTT DMPQX8R MA Inhibitor DMPQX8R RN A patent review of immunoproteasome inhibitors.Expert Opin Ther Pat. 2018 Jul;28(7):517-540. DMPQX8R RU https://www.ncbi.nlm.nih.gov/pubmed/29865878 DMG7VF1 DI DMG7VF1 DMG7VF1 DN PMID29865878-Compound-61 DMG7VF1 MI TTEAD9J DMG7VF1 MN Proteasome beta-8 (PS beta-8) DMG7VF1 MT DTT DMG7VF1 MA Inhibitor DMG7VF1 RN A patent review of immunoproteasome inhibitors.Expert Opin Ther Pat. 2018 Jul;28(7):517-540. DMG7VF1 RU https://www.ncbi.nlm.nih.gov/pubmed/29865878 DML47KS DI DML47KS DML47KS DN PMID29865878-Compound-62 DML47KS MI TTEAD9J DML47KS MN Proteasome beta-8 (PS beta-8) DML47KS MT DTT DML47KS MA Inhibitor DML47KS RN A patent review of immunoproteasome inhibitors.Expert Opin Ther Pat. 2018 Jul;28(7):517-540. DML47KS RU https://www.ncbi.nlm.nih.gov/pubmed/29865878 DMEM2I8 DI DMEM2I8 DMEM2I8 DN PMID29865878-Compound-63 DMEM2I8 MI TTEAD9J DMEM2I8 MN Proteasome beta-8 (PS beta-8) DMEM2I8 MT DTT DMEM2I8 MA Inhibitor DMEM2I8 RN A patent review of immunoproteasome inhibitors.Expert Opin Ther Pat. 2018 Jul;28(7):517-540. DMEM2I8 RU https://www.ncbi.nlm.nih.gov/pubmed/29865878 DM1U6H2 DI DM1U6H2 DM1U6H2 DN PMID29865878-Compound-64 DM1U6H2 MI TTEAD9J DM1U6H2 MN Proteasome beta-8 (PS beta-8) DM1U6H2 MT DTT DM1U6H2 MA Inhibitor DM1U6H2 RN A patent review of immunoproteasome inhibitors.Expert Opin Ther Pat. 2018 Jul;28(7):517-540. DM1U6H2 RU https://www.ncbi.nlm.nih.gov/pubmed/29865878 DMX1E6O DI DMX1E6O DMX1E6O DN PMID29865878-Compound-8 DMX1E6O MI TT68GPI DMX1E6O MN Proteasome beta-5 (PS beta-5) DMX1E6O MT DTT DMX1E6O MA Inhibitor DMX1E6O RN A patent review of immunoproteasome inhibitors.Expert Opin Ther Pat. 2018 Jul;28(7):517-540. DMX1E6O RU https://www.ncbi.nlm.nih.gov/pubmed/29865878 DMX1E6O DI DMX1E6O DMX1E6O DN PMID29865878-Compound-8 DMX1E6O MI TTEAD9J DMX1E6O MN Proteasome beta-8 (PS beta-8) DMX1E6O MT DTT DMX1E6O MA Inhibitor DMX1E6O RN A patent review of immunoproteasome inhibitors.Expert Opin Ther Pat. 2018 Jul;28(7):517-540. DMX1E6O RU https://www.ncbi.nlm.nih.gov/pubmed/29865878 DM7K3A0 DI DM7K3A0 DM7K3A0 DN PMID30074415-Compound-12 DM7K3A0 MI TT2LVK8 DM7K3A0 MN Carbonic anhydrase IX (CA-IX) DM7K3A0 MT DTT DM7K3A0 MA Inhibitor DM7K3A0 RN Carbonic anhydrase inhibitors as antitumor/antimetastatic agents: a patent review (2008-2018).Expert Opin Ther Pat. 2018 Oct;28(10):729-740. DM7K3A0 RU https://www.ncbi.nlm.nih.gov/pubmed/30074415 DM06PX4 DI DM06PX4 DM06PX4 DN PMID30074415-Compound-19 DM06PX4 MI TTUNARX DM06PX4 MN Carbonic anhydrase (CA) DM06PX4 MT DTT DM06PX4 MA Inhibitor DM06PX4 RN Carbonic anhydrase inhibitors as antitumor/antimetastatic agents: a patent review (2008-2018).Expert Opin Ther Pat. 2018 Oct;28(10):729-740. DM06PX4 RU https://www.ncbi.nlm.nih.gov/pubmed/30074415 DMX9LGW DI DMX9LGW DMX9LGW DN PMID30074415-Compound-20 DMX9LGW MI TTUNARX DMX9LGW MN Carbonic anhydrase (CA) DMX9LGW MT DTT DMX9LGW MA Inhibitor DMX9LGW RN Carbonic anhydrase inhibitors as antitumor/antimetastatic agents: a patent review (2008-2018).Expert Opin Ther Pat. 2018 Oct;28(10):729-740. DMX9LGW RU https://www.ncbi.nlm.nih.gov/pubmed/30074415 DM3NPOU DI DM3NPOU DM3NPOU DN PMID30074415-Compound-21 DM3NPOU MI TTUNARX DM3NPOU MN Carbonic anhydrase (CA) DM3NPOU MT DTT DM3NPOU MA Inhibitor DM3NPOU RN Carbonic anhydrase inhibitors as antitumor/antimetastatic agents: a patent review (2008-2018).Expert Opin Ther Pat. 2018 Oct;28(10):729-740. DM3NPOU RU https://www.ncbi.nlm.nih.gov/pubmed/30074415 DM2G8DN DI DM2G8DN DM2G8DN DN PMID30074415-Compound-GS3 DM2G8DN MI TT2LVK8 DM2G8DN MN Carbonic anhydrase IX (CA-IX) DM2G8DN MT DTT DM2G8DN MA Inhibitor DM2G8DN RN Carbonic anhydrase inhibitors as antitumor/antimetastatic agents: a patent review (2008-2018).Expert Opin Ther Pat. 2018 Oct;28(10):729-740. DM2G8DN RU https://www.ncbi.nlm.nih.gov/pubmed/30074415 DMY37VQ DI DMY37VQ DMY37VQ DN PMID30107136-Compound-Example1 DMY37VQ MI TT8ZLTI DMY37VQ MN Programmed cell death 1 ligand 1 (PD-L1) DMY37VQ MT DTT DMY37VQ MA Inhibitor DMY37VQ RN A patent review on PD-1/PD-L1 antagonists: small molecules, peptides, and macrocycles (2015-2018).Expert Opin Ther Pat. 2018 Sep;28(9):665-678. DMY37VQ RU https://www.ncbi.nlm.nih.gov/pubmed/30107136 DMD65GU DI DMD65GU DMD65GU DN PMID30107136-Compound-Example11 DMD65GU MI TT5YPJF DMD65GU MN CD80-PD-L1 interaction (CD80/PD-L1 PPI) DMD65GU MT DTT DMD65GU MA Inhibitor DMD65GU RN A patent review on PD-1/PD-L1 antagonists: small molecules, peptides, and macrocycles (2015-2018).Expert Opin Ther Pat. 2018 Sep;28(9):665-678. DMD65GU RU https://www.ncbi.nlm.nih.gov/pubmed/30107136 DMD65GU DI DMD65GU DMD65GU DN PMID30107136-Compound-Example11 DMD65GU MI TT23XQV DMD65GU MN PD-1-PD-L1 interaction (PD-1/PD-L1 PPI) DMD65GU MT DTT DMD65GU MA Inhibitor DMD65GU RN A patent review on PD-1/PD-L1 antagonists: small molecules, peptides, and macrocycles (2015-2018).Expert Opin Ther Pat. 2018 Sep;28(9):665-678. DMD65GU RU https://www.ncbi.nlm.nih.gov/pubmed/30107136 DMN2K10 DI DMN2K10 DMN2K10 DN PMID30107136-Compound-Example12 DMN2K10 MI TT5YPJF DMN2K10 MN CD80-PD-L1 interaction (CD80/PD-L1 PPI) DMN2K10 MT DTT DMN2K10 MA Inhibitor DMN2K10 RN A patent review on PD-1/PD-L1 antagonists: small molecules, peptides, and macrocycles (2015-2018).Expert Opin Ther Pat. 2018 Sep;28(9):665-678. DMN2K10 RU https://www.ncbi.nlm.nih.gov/pubmed/30107136 DMN2K10 DI DMN2K10 DMN2K10 DN PMID30107136-Compound-Example12 DMN2K10 MI TT23XQV DMN2K10 MN PD-1-PD-L1 interaction (PD-1/PD-L1 PPI) DMN2K10 MT DTT DMN2K10 MA Inhibitor DMN2K10 RN A patent review on PD-1/PD-L1 antagonists: small molecules, peptides, and macrocycles (2015-2018).Expert Opin Ther Pat. 2018 Sep;28(9):665-678. DMN2K10 RU https://www.ncbi.nlm.nih.gov/pubmed/30107136 DM4CN9K DI DM4CN9K DM4CN9K DN PMID30107136-Compound-Example13 DM4CN9K MI TT23XQV DM4CN9K MN PD-1-PD-L1 interaction (PD-1/PD-L1 PPI) DM4CN9K MT DTT DM4CN9K MA Inhibitor DM4CN9K RN A patent review on PD-1/PD-L1 antagonists: small molecules, peptides, and macrocycles (2015-2018).Expert Opin Ther Pat. 2018 Sep;28(9):665-678. DM4CN9K RU https://www.ncbi.nlm.nih.gov/pubmed/30107136 DMAUFS7 DI DMAUFS7 DMAUFS7 DN PMID30107136-Compound-Example14 DMAUFS7 MI TT23XQV DMAUFS7 MN PD-1-PD-L1 interaction (PD-1/PD-L1 PPI) DMAUFS7 MT DTT DMAUFS7 MA Inhibitor DMAUFS7 RN A patent review on PD-1/PD-L1 antagonists: small molecules, peptides, and macrocycles (2015-2018).Expert Opin Ther Pat. 2018 Sep;28(9):665-678. DMAUFS7 RU https://www.ncbi.nlm.nih.gov/pubmed/30107136 DMYHQ0S DI DMYHQ0S DMYHQ0S DN PMID30107136-Compound-Example15 DMYHQ0S MI TTNBFWK DMYHQ0S MN Programmed cell death protein 1 (PD-1) DMYHQ0S MT DTT DMYHQ0S MA Inhibitor DMYHQ0S RN A patent review on PD-1/PD-L1 antagonists: small molecules, peptides, and macrocycles (2015-2018).Expert Opin Ther Pat. 2018 Sep;28(9):665-678. DMYHQ0S RU https://www.ncbi.nlm.nih.gov/pubmed/30107136 DM6EKIV DI DM6EKIV DM6EKIV DN PMID30107136-Compound-Example16 DM6EKIV MI TTNBFWK DM6EKIV MN Programmed cell death protein 1 (PD-1) DM6EKIV MT DTT DM6EKIV MA Inhibitor DM6EKIV RN A patent review on PD-1/PD-L1 antagonists: small molecules, peptides, and macrocycles (2015-2018).Expert Opin Ther Pat. 2018 Sep;28(9):665-678. DM6EKIV RU https://www.ncbi.nlm.nih.gov/pubmed/30107136 DM9HMB4 DI DM9HMB4 DM9HMB4 DN PMID30107136-Compound-Example2 DM9HMB4 MI TT8ZLTI DM9HMB4 MN Programmed cell death 1 ligand 1 (PD-L1) DM9HMB4 MT DTT DM9HMB4 MA Inhibitor DM9HMB4 RN A patent review on PD-1/PD-L1 antagonists: small molecules, peptides, and macrocycles (2015-2018).Expert Opin Ther Pat. 2018 Sep;28(9):665-678. DM9HMB4 RU https://www.ncbi.nlm.nih.gov/pubmed/30107136 DMDCN43 DI DMDCN43 DMDCN43 DN PMID30107136-Compound-Example3 DMDCN43 MI TT23XQV DMDCN43 MN PD-1-PD-L1 interaction (PD-1/PD-L1 PPI) DMDCN43 MT DTT DMDCN43 MA Inhibitor DMDCN43 RN A patent review on PD-1/PD-L1 antagonists: small molecules, peptides, and macrocycles (2015-2018).Expert Opin Ther Pat. 2018 Sep;28(9):665-678. DMDCN43 RU https://www.ncbi.nlm.nih.gov/pubmed/30107136 DMRKLTE DI DMRKLTE DMRKLTE DN PMID30107136-Compound-Example4 DMRKLTE MI TT23XQV DMRKLTE MN PD-1-PD-L1 interaction (PD-1/PD-L1 PPI) DMRKLTE MT DTT DMRKLTE MA Inhibitor DMRKLTE RN A patent review on PD-1/PD-L1 antagonists: small molecules, peptides, and macrocycles (2015-2018).Expert Opin Ther Pat. 2018 Sep;28(9):665-678. DMRKLTE RU https://www.ncbi.nlm.nih.gov/pubmed/30107136 DMQPIK4 DI DMQPIK4 DMQPIK4 DN PMID30107136-Compound-Example41 DMQPIK4 MI TT23XQV DMQPIK4 MN PD-1-PD-L1 interaction (PD-1/PD-L1 PPI) DMQPIK4 MT DTT DMQPIK4 MA Inhibitor DMQPIK4 RN A patent review on PD-1/PD-L1 antagonists: small molecules, peptides, and macrocycles (2015-2018).Expert Opin Ther Pat. 2018 Sep;28(9):665-678. DMQPIK4 RU https://www.ncbi.nlm.nih.gov/pubmed/30107136 DM95FIN DI DM95FIN DM95FIN DN PMID30107136-Compound-Example42 DM95FIN MI TT23XQV DM95FIN MN PD-1-PD-L1 interaction (PD-1/PD-L1 PPI) DM95FIN MT DTT DM95FIN MA Inhibitor DM95FIN RN A patent review on PD-1/PD-L1 antagonists: small molecules, peptides, and macrocycles (2015-2018).Expert Opin Ther Pat. 2018 Sep;28(9):665-678. DM95FIN RU https://www.ncbi.nlm.nih.gov/pubmed/30107136 DMJSH0F DI DMJSH0F DMJSH0F DN PMID30107136-Compound-Example43 DMJSH0F MI TT23XQV DMJSH0F MN PD-1-PD-L1 interaction (PD-1/PD-L1 PPI) DMJSH0F MT DTT DMJSH0F MA Inhibitor DMJSH0F RN A patent review on PD-1/PD-L1 antagonists: small molecules, peptides, and macrocycles (2015-2018).Expert Opin Ther Pat. 2018 Sep;28(9):665-678. DMJSH0F RU https://www.ncbi.nlm.nih.gov/pubmed/30107136 DM8KAIY DI DM8KAIY DM8KAIY DN PMID30107136-Compound-Example44 DM8KAIY MI TT23XQV DM8KAIY MN PD-1-PD-L1 interaction (PD-1/PD-L1 PPI) DM8KAIY MT DTT DM8KAIY MA Inhibitor DM8KAIY RN A patent review on PD-1/PD-L1 antagonists: small molecules, peptides, and macrocycles (2015-2018).Expert Opin Ther Pat. 2018 Sep;28(9):665-678. DM8KAIY RU https://www.ncbi.nlm.nih.gov/pubmed/30107136 DMC075A DI DMC075A DMC075A DN PMID30107136-Compound-Example45 DMC075A MI TT23XQV DMC075A MN PD-1-PD-L1 interaction (PD-1/PD-L1 PPI) DMC075A MT DTT DMC075A MA Inhibitor DMC075A RN A patent review on PD-1/PD-L1 antagonists: small molecules, peptides, and macrocycles (2015-2018).Expert Opin Ther Pat. 2018 Sep;28(9):665-678. DMC075A RU https://www.ncbi.nlm.nih.gov/pubmed/30107136 DMYFSAD DI DMYFSAD DMYFSAD DN PMID30107136-Compound-Example46 DMYFSAD MI TT23XQV DMYFSAD MN PD-1-PD-L1 interaction (PD-1/PD-L1 PPI) DMYFSAD MT DTT DMYFSAD MA Inhibitor DMYFSAD RN A patent review on PD-1/PD-L1 antagonists: small molecules, peptides, and macrocycles (2015-2018).Expert Opin Ther Pat. 2018 Sep;28(9):665-678. DMYFSAD RU https://www.ncbi.nlm.nih.gov/pubmed/30107136 DM1TCBQ DI DM1TCBQ DM1TCBQ DN PMID30107136-Compound-Example47 DM1TCBQ MI TT23XQV DM1TCBQ MN PD-1-PD-L1 interaction (PD-1/PD-L1 PPI) DM1TCBQ MT DTT DM1TCBQ MA Inhibitor DM1TCBQ RN A patent review on PD-1/PD-L1 antagonists: small molecules, peptides, and macrocycles (2015-2018).Expert Opin Ther Pat. 2018 Sep;28(9):665-678. DM1TCBQ RU https://www.ncbi.nlm.nih.gov/pubmed/30107136 DMH57FG DI DMH57FG DMH57FG DN PMID30107136-Compound-Example48 DMH57FG MI TT23XQV DMH57FG MN PD-1-PD-L1 interaction (PD-1/PD-L1 PPI) DMH57FG MT DTT DMH57FG MA Inhibitor DMH57FG RN A patent review on PD-1/PD-L1 antagonists: small molecules, peptides, and macrocycles (2015-2018).Expert Opin Ther Pat. 2018 Sep;28(9):665-678. DMH57FG RU https://www.ncbi.nlm.nih.gov/pubmed/30107136 DM4D1WK DI DM4D1WK DM4D1WK DN PMID30107136-Compound-Example49 DM4D1WK MI TT23XQV DM4D1WK MN PD-1-PD-L1 interaction (PD-1/PD-L1 PPI) DM4D1WK MT DTT DM4D1WK MA Inhibitor DM4D1WK RN A patent review on PD-1/PD-L1 antagonists: small molecules, peptides, and macrocycles (2015-2018).Expert Opin Ther Pat. 2018 Sep;28(9):665-678. DM4D1WK RU https://www.ncbi.nlm.nih.gov/pubmed/30107136 DMV15GM DI DMV15GM DMV15GM DN PMID30107136-Compound-Example50 DMV15GM MI TT23XQV DMV15GM MN PD-1-PD-L1 interaction (PD-1/PD-L1 PPI) DMV15GM MT DTT DMV15GM MA Inhibitor DMV15GM RN A patent review on PD-1/PD-L1 antagonists: small molecules, peptides, and macrocycles (2015-2018).Expert Opin Ther Pat. 2018 Sep;28(9):665-678. DMV15GM RU https://www.ncbi.nlm.nih.gov/pubmed/30107136 DM08CBJ DI DM08CBJ DM08CBJ DN PMID30107136-Compound-Example51 DM08CBJ MI TT23XQV DM08CBJ MN PD-1-PD-L1 interaction (PD-1/PD-L1 PPI) DM08CBJ MT DTT DM08CBJ MA Inhibitor DM08CBJ RN A patent review on PD-1/PD-L1 antagonists: small molecules, peptides, and macrocycles (2015-2018).Expert Opin Ther Pat. 2018 Sep;28(9):665-678. DM08CBJ RU https://www.ncbi.nlm.nih.gov/pubmed/30107136 DMJ1C0A DI DMJ1C0A DMJ1C0A DN PMID30107136-Compound-Example52 DMJ1C0A MI TT23XQV DMJ1C0A MN PD-1-PD-L1 interaction (PD-1/PD-L1 PPI) DMJ1C0A MT DTT DMJ1C0A MA Inhibitor DMJ1C0A RN A patent review on PD-1/PD-L1 antagonists: small molecules, peptides, and macrocycles (2015-2018).Expert Opin Ther Pat. 2018 Sep;28(9):665-678. DMJ1C0A RU https://www.ncbi.nlm.nih.gov/pubmed/30107136 DM39FDV DI DM39FDV DM39FDV DN PMID30107136-Compound-Example53 DM39FDV MI TT23XQV DM39FDV MN PD-1-PD-L1 interaction (PD-1/PD-L1 PPI) DM39FDV MT DTT DM39FDV MA Inhibitor DM39FDV RN A patent review on PD-1/PD-L1 antagonists: small molecules, peptides, and macrocycles (2015-2018).Expert Opin Ther Pat. 2018 Sep;28(9):665-678. DM39FDV RU https://www.ncbi.nlm.nih.gov/pubmed/30107136 DM9DL1E DI DM9DL1E DM9DL1E DN PMID30107136-Compound-Example54 DM9DL1E MI TT23XQV DM9DL1E MN PD-1-PD-L1 interaction (PD-1/PD-L1 PPI) DM9DL1E MT DTT DM9DL1E MA Inhibitor DM9DL1E RN A patent review on PD-1/PD-L1 antagonists: small molecules, peptides, and macrocycles (2015-2018).Expert Opin Ther Pat. 2018 Sep;28(9):665-678. DM9DL1E RU https://www.ncbi.nlm.nih.gov/pubmed/30107136 DMZXC0D DI DMZXC0D DMZXC0D DN PMID30107136-Compound-Example57 DMZXC0D MI TT23XQV DMZXC0D MN PD-1-PD-L1 interaction (PD-1/PD-L1 PPI) DMZXC0D MT DTT DMZXC0D MA Inhibitor DMZXC0D RN A patent review on PD-1/PD-L1 antagonists: small molecules, peptides, and macrocycles (2015-2018).Expert Opin Ther Pat. 2018 Sep;28(9):665-678. DMZXC0D RU https://www.ncbi.nlm.nih.gov/pubmed/30107136 DM3AY9K DI DM3AY9K DM3AY9K DN PMID30107136-Compound-Example58 DM3AY9K MI TT23XQV DM3AY9K MN PD-1-PD-L1 interaction (PD-1/PD-L1 PPI) DM3AY9K MT DTT DM3AY9K MA Inhibitor DM3AY9K RN A patent review on PD-1/PD-L1 antagonists: small molecules, peptides, and macrocycles (2015-2018).Expert Opin Ther Pat. 2018 Sep;28(9):665-678. DM3AY9K RU https://www.ncbi.nlm.nih.gov/pubmed/30107136 DM6XWL9 DI DM6XWL9 DM6XWL9 DN PMID30107136-Compound-Example59 DM6XWL9 MI TT23XQV DM6XWL9 MN PD-1-PD-L1 interaction (PD-1/PD-L1 PPI) DM6XWL9 MT DTT DM6XWL9 MA Inhibitor DM6XWL9 RN A patent review on PD-1/PD-L1 antagonists: small molecules, peptides, and macrocycles (2015-2018).Expert Opin Ther Pat. 2018 Sep;28(9):665-678. DM6XWL9 RU https://www.ncbi.nlm.nih.gov/pubmed/30107136 DMUZ85A DI DMUZ85A DMUZ85A DN PMID30107136-Compound-Example60 DMUZ85A MI TT23XQV DMUZ85A MN PD-1-PD-L1 interaction (PD-1/PD-L1 PPI) DMUZ85A MT DTT DMUZ85A MA Inhibitor DMUZ85A RN A patent review on PD-1/PD-L1 antagonists: small molecules, peptides, and macrocycles (2015-2018).Expert Opin Ther Pat. 2018 Sep;28(9):665-678. DMUZ85A RU https://www.ncbi.nlm.nih.gov/pubmed/30107136 DMS42KH DI DMS42KH DMS42KH DN PMID30107136-Compound-Example7 DMS42KH MI TT23XQV DMS42KH MN PD-1-PD-L1 interaction (PD-1/PD-L1 PPI) DMS42KH MT DTT DMS42KH MA Inhibitor DMS42KH RN A patent review on PD-1/PD-L1 antagonists: small molecules, peptides, and macrocycles (2015-2018).Expert Opin Ther Pat. 2018 Sep;28(9):665-678. DMS42KH RU https://www.ncbi.nlm.nih.gov/pubmed/30107136 DMBIK28 DI DMBIK28 DMBIK28 DN PMID30107136-Compound-Example8 DMBIK28 MI TT23XQV DMBIK28 MN PD-1-PD-L1 interaction (PD-1/PD-L1 PPI) DMBIK28 MT DTT DMBIK28 MA Inhibitor DMBIK28 RN A patent review on PD-1/PD-L1 antagonists: small molecules, peptides, and macrocycles (2015-2018).Expert Opin Ther Pat. 2018 Sep;28(9):665-678. DMBIK28 RU https://www.ncbi.nlm.nih.gov/pubmed/30107136 DMHTJVA DI DMHTJVA DMHTJVA DN PMID30124346-Compound-13TABLE4 DMHTJVA MI TTSQIFT DMHTJVA MN 5-HT 1A receptor (HTR1A) DMHTJVA MT DTT DMHTJVA MA Agonist DMHTJVA RN 5-HT1A receptor ligands and their therapeutic applications: review of new patents.Expert Opin Ther Pat. 2018 Sep;28(9):679-689. DMHTJVA RU https://www.ncbi.nlm.nih.gov/pubmed/30124346 DMHTJVA DI DMHTJVA DMHTJVA DN PMID30124346-Compound-13TABLE4 DMHTJVA MI TTJQOD7 DMHTJVA MN 5-HT 2A receptor (HTR2A) DMHTJVA MT DTT DMHTJVA MA Ligand DMHTJVA RN 5-HT1A receptor ligands and their therapeutic applications: review of new patents.Expert Opin Ther Pat. 2018 Sep;28(9):679-689. DMHTJVA RU https://www.ncbi.nlm.nih.gov/pubmed/30124346 DMHTJVA DI DMHTJVA DMHTJVA DN PMID30124346-Compound-13TABLE4 DMHTJVA MI TTJS8PY DMHTJVA MN 5-HT 6 receptor (HTR6) DMHTJVA MT DTT DMHTJVA MA Ligand DMHTJVA RN 5-HT1A receptor ligands and their therapeutic applications: review of new patents.Expert Opin Ther Pat. 2018 Sep;28(9):679-689. DMHTJVA RU https://www.ncbi.nlm.nih.gov/pubmed/30124346 DMHTJVA DI DMHTJVA DMHTJVA DN PMID30124346-Compound-13TABLE4 DMHTJVA MI TTO9X1H DMHTJVA MN 5-HT 7 receptor (HTR7) DMHTJVA MT DTT DMHTJVA MA Ligand DMHTJVA RN 5-HT1A receptor ligands and their therapeutic applications: review of new patents.Expert Opin Ther Pat. 2018 Sep;28(9):679-689. DMHTJVA RU https://www.ncbi.nlm.nih.gov/pubmed/30124346 DMHTJVA DI DMHTJVA DMHTJVA DN PMID30124346-Compound-13TABLE4 DMHTJVA MI TTEX248 DMHTJVA MN Dopamine D2 receptor (D2R) DMHTJVA MT DTT DMHTJVA MA Ligand DMHTJVA RN 5-HT1A receptor ligands and their therapeutic applications: review of new patents.Expert Opin Ther Pat. 2018 Sep;28(9):679-689. DMHTJVA RU https://www.ncbi.nlm.nih.gov/pubmed/30124346 DM2G3VE DI DM2G3VE DM2G3VE DN PMID30124346-Compound-34TABLE4 DM2G3VE MI TTSQIFT DM2G3VE MN 5-HT 1A receptor (HTR1A) DM2G3VE MT DTT DM2G3VE MA Ligand DM2G3VE RN 5-HT1A receptor ligands and their therapeutic applications: review of new patents.Expert Opin Ther Pat. 2018 Sep;28(9):679-689. DM2G3VE RU https://www.ncbi.nlm.nih.gov/pubmed/30124346 DM2G3VE DI DM2G3VE DM2G3VE DN PMID30124346-Compound-34TABLE4 DM2G3VE MI TTJQOD7 DM2G3VE MN 5-HT 2A receptor (HTR2A) DM2G3VE MT DTT DM2G3VE MA Ligand DM2G3VE RN 5-HT1A receptor ligands and their therapeutic applications: review of new patents.Expert Opin Ther Pat. 2018 Sep;28(9):679-689. DM2G3VE RU https://www.ncbi.nlm.nih.gov/pubmed/30124346 DM2G3VE DI DM2G3VE DM2G3VE DN PMID30124346-Compound-34TABLE4 DM2G3VE MI TTJS8PY DM2G3VE MN 5-HT 6 receptor (HTR6) DM2G3VE MT DTT DM2G3VE MA Ligand DM2G3VE RN 5-HT1A receptor ligands and their therapeutic applications: review of new patents.Expert Opin Ther Pat. 2018 Sep;28(9):679-689. DM2G3VE RU https://www.ncbi.nlm.nih.gov/pubmed/30124346 DM2G3VE DI DM2G3VE DM2G3VE DN PMID30124346-Compound-34TABLE4 DM2G3VE MI TTO9X1H DM2G3VE MN 5-HT 7 receptor (HTR7) DM2G3VE MT DTT DM2G3VE MA Ligand DM2G3VE RN 5-HT1A receptor ligands and their therapeutic applications: review of new patents.Expert Opin Ther Pat. 2018 Sep;28(9):679-689. DM2G3VE RU https://www.ncbi.nlm.nih.gov/pubmed/30124346 DM2G3VE DI DM2G3VE DM2G3VE DN PMID30124346-Compound-34TABLE4 DM2G3VE MI TTEX248 DM2G3VE MN Dopamine D2 receptor (D2R) DM2G3VE MT DTT DM2G3VE MA Ligand DM2G3VE RN 5-HT1A receptor ligands and their therapeutic applications: review of new patents.Expert Opin Ther Pat. 2018 Sep;28(9):679-689. DM2G3VE RU https://www.ncbi.nlm.nih.gov/pubmed/30124346 DM3QX0R DI DM3QX0R DM3QX0R DN PMID30124346-Compound-60TABLE5 DM3QX0R MI TTSQIFT DM3QX0R MN 5-HT 1A receptor (HTR1A) DM3QX0R MT DTT DM3QX0R MA Ligand DM3QX0R RN 5-HT1A receptor ligands and their therapeutic applications: review of new patents.Expert Opin Ther Pat. 2018 Sep;28(9):679-689. DM3QX0R RU https://www.ncbi.nlm.nih.gov/pubmed/30124346 DM3QX0R DI DM3QX0R DM3QX0R DN PMID30124346-Compound-60TABLE5 DM3QX0R MI TTVIREA DM3QX0R MN Adrenergic receptor (ADR) DM3QX0R MT DTT DM3QX0R MA Ligand DM3QX0R RN 5-HT1A receptor ligands and their therapeutic applications: review of new patents.Expert Opin Ther Pat. 2018 Sep;28(9):679-689. DM3QX0R RU https://www.ncbi.nlm.nih.gov/pubmed/30124346 DM3QX0R DI DM3QX0R DM3QX0R DN PMID30124346-Compound-60TABLE5 DM3QX0R MI TTEX248 DM3QX0R MN Dopamine D2 receptor (D2R) DM3QX0R MT DTT DM3QX0R MA Ligand DM3QX0R RN 5-HT1A receptor ligands and their therapeutic applications: review of new patents.Expert Opin Ther Pat. 2018 Sep;28(9):679-689. DM3QX0R RU https://www.ncbi.nlm.nih.gov/pubmed/30124346 DMJMTNL DI DMJMTNL DMJMTNL DN PMID30124346-Compound-LDT66 DMJMTNL MI TTSQIFT DMJMTNL MN 5-HT 1A receptor (HTR1A) DMJMTNL MT DTT DMJMTNL RN 5-HT1A receptor ligands and their therapeutic applications: review of new patents.Expert Opin Ther Pat. 2018 Sep;28(9):679-689. DMJMTNL RU https://www.ncbi.nlm.nih.gov/pubmed/30124346 DMJMTNL DI DMJMTNL DMJMTNL DN PMID30124346-Compound-LDT66 DMJMTNL MI TTNGILX DMJMTNL MN Adrenergic receptor alpha-1A (ADRA1A) DMJMTNL MT DTT DMJMTNL RN 5-HT1A receptor ligands and their therapeutic applications: review of new patents.Expert Opin Ther Pat. 2018 Sep;28(9):679-689. DMJMTNL RU https://www.ncbi.nlm.nih.gov/pubmed/30124346 DMJMTNL DI DMJMTNL DMJMTNL DN PMID30124346-Compound-LDT66 DMJMTNL MI TT34BHT DMJMTNL MN Adrenergic receptor alpha-1D (ADRA1D) DMJMTNL MT DTT DMJMTNL RN 5-HT1A receptor ligands and their therapeutic applications: review of new patents.Expert Opin Ther Pat. 2018 Sep;28(9):679-689. DMJMTNL RU https://www.ncbi.nlm.nih.gov/pubmed/30124346 DM5MUNG DI DM5MUNG DM5MUNG DN PMID30124346-Compound-LDT8 DM5MUNG MI TTSQIFT DM5MUNG MN 5-HT 1A receptor (HTR1A) DM5MUNG MT DTT DM5MUNG MA Antagonist DM5MUNG RN 5-HT1A receptor ligands and their therapeutic applications: review of new patents.Expert Opin Ther Pat. 2018 Sep;28(9):679-689. DM5MUNG RU https://www.ncbi.nlm.nih.gov/pubmed/30124346 DM5MUNG DI DM5MUNG DM5MUNG DN PMID30124346-Compound-LDT8 DM5MUNG MI TTJQOD7 DM5MUNG MN 5-HT 2A receptor (HTR2A) DM5MUNG MT DTT DM5MUNG MA Antagonist DM5MUNG RN 5-HT1A receptor ligands and their therapeutic applications: review of new patents.Expert Opin Ther Pat. 2018 Sep;28(9):679-689. DM5MUNG RU https://www.ncbi.nlm.nih.gov/pubmed/30124346 DM5MUNG DI DM5MUNG DM5MUNG DN PMID30124346-Compound-LDT8 DM5MUNG MI TTNGILX DM5MUNG MN Adrenergic receptor alpha-1A (ADRA1A) DM5MUNG MT DTT DM5MUNG MA Antagonist DM5MUNG RN 5-HT1A receptor ligands and their therapeutic applications: review of new patents.Expert Opin Ther Pat. 2018 Sep;28(9):679-689. DM5MUNG RU https://www.ncbi.nlm.nih.gov/pubmed/30124346 DM5MUNG DI DM5MUNG DM5MUNG DN PMID30124346-Compound-LDT8 DM5MUNG MI TT34BHT DM5MUNG MN Adrenergic receptor alpha-1D (ADRA1D) DM5MUNG MT DTT DM5MUNG MA Antagonist DM5MUNG RN 5-HT1A receptor ligands and their therapeutic applications: review of new patents.Expert Opin Ther Pat. 2018 Sep;28(9):679-689. DM5MUNG RU https://www.ncbi.nlm.nih.gov/pubmed/30124346 DMQU10C DI DMQU10C DMQU10C DN PMID30185082-Compound-14 DMQU10C MI TT9NXW4 DMQU10C MN Sigma intracellular receptor 2 (TMEM97) DMQU10C MT DTT DMQU10C MA Ligand DMQU10C RN The sigma-2 (-2) receptor: a review of recent patent applications: 2013-2018.Expert Opin Ther Pat. 2018 Sep;28(9):655-663. DMQU10C RU https://www.ncbi.nlm.nih.gov/pubmed/30185082 DMYFLT1 DI DMYFLT1 DMYFLT1 DN PMID30185082-Compound-27 DMYFLT1 MI TT9NXW4 DMYFLT1 MN Sigma intracellular receptor 2 (TMEM97) DMYFLT1 MT DTT DMYFLT1 MA Ligand DMYFLT1 RN The sigma-2 (-2) receptor: a review of recent patent applications: 2013-2018.Expert Opin Ther Pat. 2018 Sep;28(9):655-663. DMYFLT1 RU https://www.ncbi.nlm.nih.gov/pubmed/30185082 DMI0WHE DI DMI0WHE DMI0WHE DN PMID30185082-Compound-28 DMI0WHE MI TT9NXW4 DMI0WHE MN Sigma intracellular receptor 2 (TMEM97) DMI0WHE MT DTT DMI0WHE MA Ligand DMI0WHE RN The sigma-2 (-2) receptor: a review of recent patent applications: 2013-2018.Expert Opin Ther Pat. 2018 Sep;28(9):655-663. DMI0WHE RU https://www.ncbi.nlm.nih.gov/pubmed/30185082 DM9GX0F DI DM9GX0F DM9GX0F DN PMID30185082-Compound-53 DM9GX0F MI TT9NXW4 DM9GX0F MN Sigma intracellular receptor 2 (TMEM97) DM9GX0F MT DTT DM9GX0F MA Ligand DM9GX0F RN The sigma-2 (-2) receptor: a review of recent patent applications: 2013-2018.Expert Opin Ther Pat. 2018 Sep;28(9):655-663. DM9GX0F RU https://www.ncbi.nlm.nih.gov/pubmed/30185082 DMKP14O DI DMKP14O DMKP14O DN PMID30185082-Compound-54 DMKP14O MI TT9NXW4 DMKP14O MN Sigma intracellular receptor 2 (TMEM97) DMKP14O MT DTT DMKP14O MA Ligand DMKP14O RN The sigma-2 (-2) receptor: a review of recent patent applications: 2013-2018.Expert Opin Ther Pat. 2018 Sep;28(9):655-663. DMKP14O RU https://www.ncbi.nlm.nih.gov/pubmed/30185082 DMW8V4R DI DMW8V4R DMW8V4R DN PMID30185082-Compound-55 DMW8V4R MI TT9NXW4 DMW8V4R MN Sigma intracellular receptor 2 (TMEM97) DMW8V4R MT DTT DMW8V4R MA Ligand DMW8V4R RN The sigma-2 (-2) receptor: a review of recent patent applications: 2013-2018.Expert Opin Ther Pat. 2018 Sep;28(9):655-663. DMW8V4R RU https://www.ncbi.nlm.nih.gov/pubmed/30185082 DMLGKYI DI DMLGKYI DMLGKYI DN PMID30185082-Compound-56 DMLGKYI MI TT9NXW4 DMLGKYI MN Sigma intracellular receptor 2 (TMEM97) DMLGKYI MT DTT DMLGKYI MA Ligand DMLGKYI RN The sigma-2 (-2) receptor: a review of recent patent applications: 2013-2018.Expert Opin Ther Pat. 2018 Sep;28(9):655-663. DMLGKYI RU https://www.ncbi.nlm.nih.gov/pubmed/30185082 DMNDF1Z DI DMNDF1Z DMNDF1Z DN PMID30185082-Compound-57 DMNDF1Z MI TT5TPI6 DMNDF1Z MN Opioid receptor sigma 1 (OPRS1) DMNDF1Z MT DTT DMNDF1Z MA Ligand DMNDF1Z RN The sigma-2 (-2) receptor: a review of recent patent applications: 2013-2018.Expert Opin Ther Pat. 2018 Sep;28(9):655-663. DMNDF1Z RU https://www.ncbi.nlm.nih.gov/pubmed/30185082 DMNDF1Z DI DMNDF1Z DMNDF1Z DN PMID30185082-Compound-57 DMNDF1Z MI TT9NXW4 DMNDF1Z MN Sigma intracellular receptor 2 (TMEM97) DMNDF1Z MT DTT DMNDF1Z MA Ligand DMNDF1Z RN The sigma-2 (-2) receptor: a review of recent patent applications: 2013-2018.Expert Opin Ther Pat. 2018 Sep;28(9):655-663. DMNDF1Z RU https://www.ncbi.nlm.nih.gov/pubmed/30185082 DMW2S0J DI DMW2S0J DMW2S0J DN PMID30185082-Compound-63 DMW2S0J MI TT9NXW4 DMW2S0J MN Sigma intracellular receptor 2 (TMEM97) DMW2S0J MT DTT DMW2S0J MA Ligand DMW2S0J RN The sigma-2 (-2) receptor: a review of recent patent applications: 2013-2018.Expert Opin Ther Pat. 2018 Sep;28(9):655-663. DMW2S0J RU https://www.ncbi.nlm.nih.gov/pubmed/30185082 DMKD470 DI DMKD470 DMKD470 DN PMID30185082-Compound-64 DMKD470 MI TT5TPI6 DMKD470 MN Opioid receptor sigma 1 (OPRS1) DMKD470 MT DTT DMKD470 MA Ligand DMKD470 RN The sigma-2 (-2) receptor: a review of recent patent applications: 2013-2018.Expert Opin Ther Pat. 2018 Sep;28(9):655-663. DMKD470 RU https://www.ncbi.nlm.nih.gov/pubmed/30185082 DMKD470 DI DMKD470 DMKD470 DN PMID30185082-Compound-64 DMKD470 MI TT9NXW4 DMKD470 MN Sigma intracellular receptor 2 (TMEM97) DMKD470 MT DTT DMKD470 MA Ligand DMKD470 RN The sigma-2 (-2) receptor: a review of recent patent applications: 2013-2018.Expert Opin Ther Pat. 2018 Sep;28(9):655-663. DMKD470 RU https://www.ncbi.nlm.nih.gov/pubmed/30185082 DME0RJ2 DI DME0RJ2 DME0RJ2 DN PMID30259754-Compound-INT-767 DME0RJ2 MI TTS4UGC DME0RJ2 MN Farnesoid X-activated receptor (FXR) DME0RJ2 MT DTT DME0RJ2 MA Agonist DME0RJ2 RN FXR modulators for enterohepatic and metabolic diseases.Expert Opin Ther Pat. 2018 Nov;28(11):765-782. DME0RJ2 RU https://www.ncbi.nlm.nih.gov/pubmed/30259754 DMZ5CDY DI DMZ5CDY DMZ5CDY DN PMID30259754-Compound-LY2562175 DMZ5CDY MI TTS4UGC DMZ5CDY MN Farnesoid X-activated receptor (FXR) DMZ5CDY MT DTT DMZ5CDY MA Agonist DMZ5CDY RN FXR modulators for enterohepatic and metabolic diseases.Expert Opin Ther Pat. 2018 Nov;28(11):765-782. DMZ5CDY RU https://www.ncbi.nlm.nih.gov/pubmed/30259754 DM78IN5 DI DM78IN5 DM78IN5 DN PMID30259754-Compound-Px-102 DM78IN5 MI TTS4UGC DM78IN5 MN Farnesoid X-activated receptor (FXR) DM78IN5 MT DTT DM78IN5 MA Agonist DM78IN5 RN FXR modulators for enterohepatic and metabolic diseases.Expert Opin Ther Pat. 2018 Nov;28(11):765-782. DM78IN5 RU https://www.ncbi.nlm.nih.gov/pubmed/30259754 DMVP16K DI DMVP16K DMVP16K DN PMID30259754-Compound-pyrrole[2,3-d]azepines DMVP16K MI TTS4UGC DMVP16K MN Farnesoid X-activated receptor (FXR) DMVP16K MT DTT DMVP16K MA Agonist DMVP16K RN FXR modulators for enterohepatic and metabolic diseases.Expert Opin Ther Pat. 2018 Nov;28(11):765-782. DMVP16K RU https://www.ncbi.nlm.nih.gov/pubmed/30259754 DMDKSJQ DI DMDKSJQ DMDKSJQ DN PMID30259754-Compound-WAY-362450 DMDKSJQ MI TTS4UGC DMDKSJQ MN Farnesoid X-activated receptor (FXR) DMDKSJQ MT DTT DMDKSJQ MA Agonist DMDKSJQ RN FXR modulators for enterohepatic and metabolic diseases.Expert Opin Ther Pat. 2018 Nov;28(11):765-782. DMDKSJQ RU https://www.ncbi.nlm.nih.gov/pubmed/30259754 DM52MKV DI DM52MKV DM52MKV DN PMID30273516-Compound-1 DM52MKV MI TTCW0KX DM52MKV MN Glutaminase (GLS) DM52MKV MT DTT DM52MKV MA Inhibitor DM52MKV RN Glutaminase inhibitors: a patent review.Expert Opin Ther Pat. 2018 Nov;28(11):823-835. DM52MKV RU https://www.ncbi.nlm.nih.gov/pubmed/30273516 DMIWEZH DI DMIWEZH DMIWEZH DN PMID30273516-Compound-12 DMIWEZH MI TTCW0KX DMIWEZH MN Glutaminase (GLS) DMIWEZH MT DTT DMIWEZH MA Inhibitor DMIWEZH RN Glutaminase inhibitors: a patent review.Expert Opin Ther Pat. 2018 Nov;28(11):823-835. DMIWEZH RU https://www.ncbi.nlm.nih.gov/pubmed/30273516 DMK9TJP DI DMK9TJP DMK9TJP DN PMID30273516-Compound-13 DMK9TJP MI TTCW0KX DMK9TJP MN Glutaminase (GLS) DMK9TJP MT DTT DMK9TJP MA Inhibitor DMK9TJP RN Glutaminase inhibitors: a patent review.Expert Opin Ther Pat. 2018 Nov;28(11):823-835. DMK9TJP RU https://www.ncbi.nlm.nih.gov/pubmed/30273516 DMURZHA DI DMURZHA DMURZHA DN PMID30273516-Compound-14 DMURZHA MI TTCW0KX DMURZHA MN Glutaminase (GLS) DMURZHA MT DTT DMURZHA MA Inhibitor DMURZHA RN Glutaminase inhibitors: a patent review.Expert Opin Ther Pat. 2018 Nov;28(11):823-835. DMURZHA RU https://www.ncbi.nlm.nih.gov/pubmed/30273516 DMSD647 DI DMSD647 DMSD647 DN PMID30273516-Compound-15 DMSD647 MI TTCW0KX DMSD647 MN Glutaminase (GLS) DMSD647 MT DTT DMSD647 MA Inhibitor DMSD647 RN Glutaminase inhibitors: a patent review.Expert Opin Ther Pat. 2018 Nov;28(11):823-835. DMSD647 RU https://www.ncbi.nlm.nih.gov/pubmed/30273516 DMVZA0U DI DMVZA0U DMVZA0U DN PMID30273516-Compound-22a DMVZA0U MI TTCW0KX DMVZA0U MN Glutaminase (GLS) DMVZA0U MT DTT DMVZA0U MA Inhibitor DMVZA0U RN Glutaminase inhibitors: a patent review.Expert Opin Ther Pat. 2018 Nov;28(11):823-835. DMVZA0U RU https://www.ncbi.nlm.nih.gov/pubmed/30273516 DMZ5O3K DI DMZ5O3K DMZ5O3K DN PMID30273516-Compound-22b DMZ5O3K MI TTCW0KX DMZ5O3K MN Glutaminase (GLS) DMZ5O3K MT DTT DMZ5O3K MA Inhibitor DMZ5O3K RN Glutaminase inhibitors: a patent review.Expert Opin Ther Pat. 2018 Nov;28(11):823-835. DMZ5O3K RU https://www.ncbi.nlm.nih.gov/pubmed/30273516 DM8NBJV DI DM8NBJV DM8NBJV DN PMID30273516-Compound-37 DM8NBJV MI TTCW0KX DM8NBJV MN Glutaminase (GLS) DM8NBJV MT DTT DM8NBJV MA Inhibitor DM8NBJV RN Glutaminase inhibitors: a patent review.Expert Opin Ther Pat. 2018 Nov;28(11):823-835. DM8NBJV RU https://www.ncbi.nlm.nih.gov/pubmed/30273516 DMRPJBF DI DMRPJBF DMRPJBF DN PMID30273516-Compound-38 DMRPJBF MI TTCW0KX DMRPJBF MN Glutaminase (GLS) DMRPJBF MT DTT DMRPJBF MA Inhibitor DMRPJBF RN Glutaminase inhibitors: a patent review.Expert Opin Ther Pat. 2018 Nov;28(11):823-835. DMRPJBF RU https://www.ncbi.nlm.nih.gov/pubmed/30273516 DMBF3ZE DI DMBF3ZE DMBF3ZE DN PMID30273516-Compound-39 DMBF3ZE MI TTCW0KX DMBF3ZE MN Glutaminase (GLS) DMBF3ZE MT DTT DMBF3ZE MA Inhibitor DMBF3ZE RN Glutaminase inhibitors: a patent review.Expert Opin Ther Pat. 2018 Nov;28(11):823-835. DMBF3ZE RU https://www.ncbi.nlm.nih.gov/pubmed/30273516 DM5N8YJ DI DM5N8YJ DM5N8YJ DN PMID30273516-Compound-40 DM5N8YJ MI TTCW0KX DM5N8YJ MN Glutaminase (GLS) DM5N8YJ MT DTT DM5N8YJ MA Inhibitor DM5N8YJ RN Glutaminase inhibitors: a patent review.Expert Opin Ther Pat. 2018 Nov;28(11):823-835. DM5N8YJ RU https://www.ncbi.nlm.nih.gov/pubmed/30273516 DM5UBMJ DI DM5UBMJ DM5UBMJ DN PMID30273516-Compound-41 DM5UBMJ MI TTCW0KX DM5UBMJ MN Glutaminase (GLS) DM5UBMJ MT DTT DM5UBMJ MA Inhibitor DM5UBMJ RN Glutaminase inhibitors: a patent review.Expert Opin Ther Pat. 2018 Nov;28(11):823-835. DM5UBMJ RU https://www.ncbi.nlm.nih.gov/pubmed/30273516 DMM83WL DI DMM83WL DMM83WL DN PMID30280939-Compound-US20170128558 DMM83WL MI TTOK0LR DMM83WL MN Toll-like receptor (TLR) DMM83WL MT DTT DMM83WL MA Agonist DMM83WL RN Synthetic Toll-like receptor agonists for the development of powerful malaria vaccines: a patent review.Expert Opin Ther Pat. 2018 Nov;28(11):837-847. DMM83WL RU https://www.ncbi.nlm.nih.gov/pubmed/30280939 DMPVW2Q DI DMPVW2Q DMPVW2Q DN PMID30280939-Compound-US20179642901 DMPVW2Q MI TTOK0LR DMPVW2Q MN Toll-like receptor (TLR) DMPVW2Q MT DTT DMPVW2Q MA Agonist DMPVW2Q RN Synthetic Toll-like receptor agonists for the development of powerful malaria vaccines: a patent review.Expert Opin Ther Pat. 2018 Nov;28(11):837-847. DMPVW2Q RU https://www.ncbi.nlm.nih.gov/pubmed/30280939 DM6VP5K DI DM6VP5K DM6VP5K DN PMID30280939-Compound-WO2005070959 DM6VP5K MI TTOK0LR DM6VP5K MN Toll-like receptor (TLR) DM6VP5K MT DTT DM6VP5K MA Immune response agent DM6VP5K RN Synthetic Toll-like receptor agonists for the development of powerful malaria vaccines: a patent review.Expert Opin Ther Pat. 2018 Nov;28(11):837-847. DM6VP5K RU https://www.ncbi.nlm.nih.gov/pubmed/30280939 DMLVSEK DI DMLVSEK DMLVSEK DN PMID30280939-Compound-WO200606195 DMLVSEK MI TTOK0LR DMLVSEK MN Toll-like receptor (TLR) DMLVSEK MT DTT DMLVSEK MA Agonist DMLVSEK RN Synthetic Toll-like receptor agonists for the development of powerful malaria vaccines: a patent review.Expert Opin Ther Pat. 2018 Nov;28(11):837-847. DMLVSEK RU https://www.ncbi.nlm.nih.gov/pubmed/30280939 DM7DG0M DI DM7DG0M DM7DG0M DN PMID30280939-Compound-WO2008009652 DM7DG0M MI TTOK0LR DM7DG0M MN Toll-like receptor (TLR) DM7DG0M MT DTT DM7DG0M MA Agonist DM7DG0M RN Synthetic Toll-like receptor agonists for the development of powerful malaria vaccines: a patent review.Expert Opin Ther Pat. 2018 Nov;28(11):837-847. DM7DG0M RU https://www.ncbi.nlm.nih.gov/pubmed/30280939 DMXRHCJ DI DMXRHCJ DMXRHCJ DN PMID30280939-Compound-WO2009082440 DMXRHCJ MI TTOK0LR DMXRHCJ MN Toll-like receptor (TLR) DMXRHCJ MT DTT DMXRHCJ MA Agonist DMXRHCJ RN Synthetic Toll-like receptor agonists for the development of powerful malaria vaccines: a patent review.Expert Opin Ther Pat. 2018 Nov;28(11):837-847. DMXRHCJ RU https://www.ncbi.nlm.nih.gov/pubmed/30280939 DMRB7LI DI DMRB7LI DMRB7LI DN PMID30280939-Compound-WO2013119856 DMRB7LI MI TTOK0LR DMRB7LI MN Toll-like receptor (TLR) DMRB7LI MT DTT DMRB7LI MA Agonist DMRB7LI RN Synthetic Toll-like receptor agonists for the development of powerful malaria vaccines: a patent review.Expert Opin Ther Pat. 2018 Nov;28(11):837-847. DMRB7LI RU https://www.ncbi.nlm.nih.gov/pubmed/30280939 DMUKIEJ DI DMUKIEJ DMUKIEJ DN PMID30280939-Compound-WO2013148426 DMUKIEJ MI TTOK0LR DMUKIEJ MN Toll-like receptor (TLR) DMUKIEJ MT DTT DMUKIEJ MA Agonist DMUKIEJ RN Synthetic Toll-like receptor agonists for the development of powerful malaria vaccines: a patent review.Expert Opin Ther Pat. 2018 Nov;28(11):837-847. DMUKIEJ RU https://www.ncbi.nlm.nih.gov/pubmed/30280939 DM4Z2KY DI DM4Z2KY DM4Z2KY DN PMID30280939-Compound-WO2013148427 DM4Z2KY MI TTOK0LR DM4Z2KY MN Toll-like receptor (TLR) DM4Z2KY MT DTT DM4Z2KY MA Agonist DM4Z2KY RN Synthetic Toll-like receptor agonists for the development of powerful malaria vaccines: a patent review.Expert Opin Ther Pat. 2018 Nov;28(11):837-847. DM4Z2KY RU https://www.ncbi.nlm.nih.gov/pubmed/30280939 DM4ILAK DI DM4ILAK DM4ILAK DN PMID30280939-Compound-WO2015035128 DM4ILAK MI TTOK0LR DM4ILAK MN Toll-like receptor (TLR) DM4ILAK MT DTT DM4ILAK MA Agonist DM4ILAK RN Synthetic Toll-like receptor agonists for the development of powerful malaria vaccines: a patent review.Expert Opin Ther Pat. 2018 Nov;28(11):837-847. DM4ILAK RU https://www.ncbi.nlm.nih.gov/pubmed/30280939 DM5K3DF DI DM5K3DF DM5K3DF DN PMID30280939-Compound-WO2015091734 DM5K3DF MI TTOK0LR DM5K3DF MN Toll-like receptor (TLR) DM5K3DF MT DTT DM5K3DF MA Agonist DM5K3DF RN Synthetic Toll-like receptor agonists for the development of powerful malaria vaccines: a patent review.Expert Opin Ther Pat. 2018 Nov;28(11):837-847. DM5K3DF RU https://www.ncbi.nlm.nih.gov/pubmed/30280939 DMGCE3Z DI DMGCE3Z DMGCE3Z DN PMID30280939-Compound-WO2015150568 DMGCE3Z MI TTOK0LR DMGCE3Z MN Toll-like receptor (TLR) DMGCE3Z MT DTT DMGCE3Z MA Agonist DMGCE3Z RN Synthetic Toll-like receptor agonists for the development of powerful malaria vaccines: a patent review.Expert Opin Ther Pat. 2018 Nov;28(11):837-847. DMGCE3Z RU https://www.ncbi.nlm.nih.gov/pubmed/30280939 DMSWI67 DI DMSWI67 DMSWI67 DN Polycyclic compound 1 DMSWI67 MI TTYLQ8V DMSWI67 MN Prostaglandin E synthase (PTGES) DMSWI67 MT DTT DMSWI67 MA Inhibitor DMSWI67 RN Microsomal prostaglandin E2 synthase-1 inhibitors: a patent review.Expert Opin Ther Pat. 2017 Sep;27(9):1047-1059. DMSWI67 RU https://www.ncbi.nlm.nih.gov/pubmed/28627961 DMPHCJ5 DI DMPHCJ5 DMPHCJ5 DN Polyhydroxy benzamide derivative 1 DMPHCJ5 MI TTULVH8 DMPHCJ5 MN Tyrosinase (TYR) DMPHCJ5 MT DTT DMPHCJ5 MA Inhibitor DMPHCJ5 RN Tyrosinase inhibitors: a patent review (2011-2015).Expert Opin Ther Pat. 2016;26(3):347-62. DMPHCJ5 RU https://www.ncbi.nlm.nih.gov/pubmed/26815044 DM0BRNU DI DM0BRNU DM0BRNU DN Polyhydroxy benzamide derivative 2 DM0BRNU MI TTULVH8 DM0BRNU MN Tyrosinase (TYR) DM0BRNU MT DTT DM0BRNU MA Inhibitor DM0BRNU RN Tyrosinase inhibitors: a patent review (2011-2015).Expert Opin Ther Pat. 2016;26(3):347-62. DM0BRNU RU https://www.ncbi.nlm.nih.gov/pubmed/26815044 DMCLZWS DI DMCLZWS DMCLZWS DN Polyhydroxy benzamide derivative 3 DMCLZWS MI TTULVH8 DMCLZWS MN Tyrosinase (TYR) DMCLZWS MT DTT DMCLZWS MA Inhibitor DMCLZWS RN Tyrosinase inhibitors: a patent review (2011-2015).Expert Opin Ther Pat. 2016;26(3):347-62. DMCLZWS RU https://www.ncbi.nlm.nih.gov/pubmed/26815044 DM6QBV2 DI DM6QBV2 DM6QBV2 DN Polyhydroxy benzamide derivative 4 DM6QBV2 MI TTULVH8 DM6QBV2 MN Tyrosinase (TYR) DM6QBV2 MT DTT DM6QBV2 MA Inhibitor DM6QBV2 RN Tyrosinase inhibitors: a patent review (2011-2015).Expert Opin Ther Pat. 2016;26(3):347-62. DM6QBV2 RU https://www.ncbi.nlm.nih.gov/pubmed/26815044 DMZC6AI DI DMZC6AI DMZC6AI DN Polyhydroxy benzamide derivative 5 DMZC6AI MI TTULVH8 DMZC6AI MN Tyrosinase (TYR) DMZC6AI MT DTT DMZC6AI MA Inhibitor DMZC6AI RN Tyrosinase inhibitors: a patent review (2011-2015).Expert Opin Ther Pat. 2016;26(3):347-62. DMZC6AI RU https://www.ncbi.nlm.nih.gov/pubmed/26815044 DMDLS54 DI DMDLS54 DMDLS54 DN Poly-substituted azoles statin lactone derivative 1 DMDLS54 MI TTPADOQ DMDLS54 MN HMG-CoA reductase (HMGCR) DMDLS54 MT DTT DMDLS54 MA Inhibitor DMDLS54 RN HMG-CoA Reductase inhibitors: an updated review of patents of novel compounds and formulations (2011-2015).Expert Opin Ther Pat. 2016 Nov;26(11):1257-1272. DMDLS54 RU https://www.ncbi.nlm.nih.gov/pubmed/27537201 DM5G3CN DI DM5G3CN DM5G3CN DN Poly-substituted azoles statin lactone derivative 2 DM5G3CN MI TTPADOQ DM5G3CN MN HMG-CoA reductase (HMGCR) DM5G3CN MT DTT DM5G3CN MA Inhibitor DM5G3CN RN HMG-CoA Reductase inhibitors: an updated review of patents of novel compounds and formulations (2011-2015).Expert Opin Ther Pat. 2016 Nov;26(11):1257-1272. DM5G3CN RU https://www.ncbi.nlm.nih.gov/pubmed/27537201 DMQJ38W DI DMQJ38W DMQJ38W DN Poly-substituted miazine derivative 1 DMQJ38W MI TTPADOQ DMQJ38W MN HMG-CoA reductase (HMGCR) DMQJ38W MT DTT DMQJ38W MA Inhibitor DMQJ38W RN HMG-CoA Reductase inhibitors: an updated review of patents of novel compounds and formulations (2011-2015).Expert Opin Ther Pat. 2016 Nov;26(11):1257-1272. DMQJ38W RU https://www.ncbi.nlm.nih.gov/pubmed/27537201 DMH2AYV DI DMH2AYV DMH2AYV DN Proline amide derivative 1 DMH2AYV MI TTTJZ4M DMH2AYV MN Prolylcarboxypeptidase (PRCP) DMH2AYV MT DTT DMH2AYV MA Inhibitor DMH2AYV RN Prolylcarboxypeptidase (PrCP) inhibitors and the therapeutic uses thereof: a patent review.Expert Opin Ther Pat. 2017 Oct;27(10):1077-1088. DMH2AYV RU https://www.ncbi.nlm.nih.gov/pubmed/28699813 DME57SJ DI DME57SJ DME57SJ DN P-toluenesulfonate derivative 1 DME57SJ MI TTZCRP3 DME57SJ MN ERK activator kinase (MEK) DME57SJ MT DTT DME57SJ MA Inhibitor DME57SJ RN MEK inhibitors in oncology: a patent review (2015-Present).Expert Opin Ther Pat. 2017 Aug;27(8):887-906. DME57SJ RU https://www.ncbi.nlm.nih.gov/pubmed/28594589 DM92SWJ DI DM92SWJ DM92SWJ DN Purin-6-one derivative 1 DM92SWJ MI TTJGW1Z DM92SWJ MN Phosphodiesterase 2A (PDE2A) DM92SWJ MT DTT DM92SWJ MA Inhibitor DM92SWJ RN Towards selective phosphodiesterase 2A (PDE2A) inhibitors: a patent review (2010 - present).Expert Opin Ther Pat. 2016 Aug;26(8):933-46. DM92SWJ RU https://www.ncbi.nlm.nih.gov/pubmed/27321640 DMB65Z4 DI DMB65Z4 DMB65Z4 DN Purine derivative 1 DMB65Z4 MI TT6OEDT DMB65Z4 MN Cannabinoid receptor 1 (CB1) DMB65Z4 MT DTT DMB65Z4 MA Antagonist DMB65Z4 RN A comprehensive patents review on cannabinoid 1 receptor antagonists as antiobesity agents. Expert Opin Ther Pat. 2015 Oct;25(10):1093-116. DMB65Z4 RU https://pubmed.ncbi.nlm.nih.gov/26161824 DMNRG0P DI DMNRG0P DMNRG0P DN Purine derivative 2 DMNRG0P MI TT6OEDT DMNRG0P MN Cannabinoid receptor 1 (CB1) DMNRG0P MT DTT DMNRG0P MA Antagonist DMNRG0P RN A comprehensive patents review on cannabinoid 1 receptor antagonists as antiobesity agents. Expert Opin Ther Pat. 2015 Oct;25(10):1093-116. DMNRG0P RU https://pubmed.ncbi.nlm.nih.gov/26161824 DMPI2S9 DI DMPI2S9 DMPI2S9 DN Purine derivative 3 DMPI2S9 MI TT6OEDT DMPI2S9 MN Cannabinoid receptor 1 (CB1) DMPI2S9 MT DTT DMPI2S9 MA Antagonist DMPI2S9 RN A comprehensive patents review on cannabinoid 1 receptor antagonists as antiobesity agents. Expert Opin Ther Pat. 2015 Oct;25(10):1093-116. DMPI2S9 RU https://pubmed.ncbi.nlm.nih.gov/26161824 DMYD5SQ DI DMYD5SQ DMYD5SQ DN Purine derivative 4 DMYD5SQ MI TTMBO1Z DMYD5SQ MN Cyclin-dependent kinase (CDK) DMYD5SQ MT DTT DMYD5SQ MA Inhibitor DMYD5SQ RN Cyclin-dependent kinase inhibitors for cancer therapy: a patent review (2009 - 2014).Expert Opin Ther Pat. 2015;25(9):953-70. DMYD5SQ RU https://www.ncbi.nlm.nih.gov/pubmed/26161698 DMMVG2O DI DMMVG2O DMMVG2O DN Pyrano[2,3-b]pyridine derivative 1 DMMVG2O MI TT6OEDT DMMVG2O MN Cannabinoid receptor 1 (CB1) DMMVG2O MT DTT DMMVG2O MA Antagonist DMMVG2O RN A comprehensive patents review on cannabinoid 1 receptor antagonists as antiobesity agents. Expert Opin Ther Pat. 2015 Oct;25(10):1093-116. DMMVG2O RU https://pubmed.ncbi.nlm.nih.gov/26161824 DMOJ8P1 DI DMOJ8P1 DMOJ8P1 DN Pyrano[2,3-b]pyridine derivative 2 DMOJ8P1 MI TT6OEDT DMOJ8P1 MN Cannabinoid receptor 1 (CB1) DMOJ8P1 MT DTT DMOJ8P1 MA Antagonist DMOJ8P1 RN A comprehensive patents review on cannabinoid 1 receptor antagonists as antiobesity agents. Expert Opin Ther Pat. 2015 Oct;25(10):1093-116. DMOJ8P1 RU https://pubmed.ncbi.nlm.nih.gov/26161824 DM3RAU4 DI DM3RAU4 DM3RAU4 DN Pyrazine carboxamide derivative 1 DM3RAU4 MI TTF8P9I DM3RAU4 MN Diacylglycerol acyltransferase 1 (DGAT1) DM3RAU4 MT DTT DM3RAU4 MA Inhibitor DM3RAU4 RN Acyltransferase inhibitors: a patent review (2010-present).Expert Opin Ther Pat. 2015 Feb;25(2):145-58. DM3RAU4 RU https://www.ncbi.nlm.nih.gov/pubmed/25470667 DMP1MDV DI DMP1MDV DMP1MDV DN Pyrazino[2,1-a]isoquinolin derivative 1 DMP1MDV MI TT3Z6Y9 DMP1MDV MN Cysteines of Keap1 (KEAP1 Cysteines) DMP1MDV MT DTT DMP1MDV MA Modulator DMP1MDV RN Recent progress in the development of small molecule Nrf2 modulators: a patent review (2012-2016).Expert Opin Ther Pat. 2017 Jul;27(7):763-785. DMP1MDV RU https://www.ncbi.nlm.nih.gov/pubmed/28454500 DMP1MDV DI DMP1MDV DMP1MDV DN Pyrazino[2,1-a]isoquinolin derivative 1 DMP1MDV MI TTA6ZN2 DMP1MDV MN Nuclear factor erythroid 2-related factor 2 (Nrf2) DMP1MDV MT DTT DMP1MDV MA Activator DMP1MDV RN Recent progress in the development of small molecule Nrf2 modulators: a patent review (2012-2016).Expert Opin Ther Pat. 2017 Jul;27(7):763-785. DMP1MDV RU https://www.ncbi.nlm.nih.gov/pubmed/28454500 DMYXKQ3 DI DMYXKQ3 DMYXKQ3 DN Pyrazino[2,1-a]isoquinolin derivative 2 DMYXKQ3 MI TT3Z6Y9 DMYXKQ3 MN Cysteines of Keap1 (KEAP1 Cysteines) DMYXKQ3 MT DTT DMYXKQ3 MA Modulator DMYXKQ3 RN Recent progress in the development of small molecule Nrf2 modulators: a patent review (2012-2016).Expert Opin Ther Pat. 2017 Jul;27(7):763-785. DMYXKQ3 RU https://www.ncbi.nlm.nih.gov/pubmed/28454500 DMYXKQ3 DI DMYXKQ3 DMYXKQ3 DN Pyrazino[2,1-a]isoquinolin derivative 2 DMYXKQ3 MI TTA6ZN2 DMYXKQ3 MN Nuclear factor erythroid 2-related factor 2 (Nrf2) DMYXKQ3 MT DTT DMYXKQ3 MA Activator DMYXKQ3 RN Recent progress in the development of small molecule Nrf2 modulators: a patent review (2012-2016).Expert Opin Ther Pat. 2017 Jul;27(7):763-785. DMYXKQ3 RU https://www.ncbi.nlm.nih.gov/pubmed/28454500 DMXYU3I DI DMXYU3I DMXYU3I DN Pyrazino[2,1-a]isoquinolin derivative 3 DMXYU3I MI TT3Z6Y9 DMXYU3I MN Cysteines of Keap1 (KEAP1 Cysteines) DMXYU3I MT DTT DMXYU3I MA Modulator DMXYU3I RN Recent progress in the development of small molecule Nrf2 modulators: a patent review (2012-2016).Expert Opin Ther Pat. 2017 Jul;27(7):763-785. DMXYU3I RU https://www.ncbi.nlm.nih.gov/pubmed/28454500 DMXYU3I DI DMXYU3I DMXYU3I DN Pyrazino[2,1-a]isoquinolin derivative 3 DMXYU3I MI TTA6ZN2 DMXYU3I MN Nuclear factor erythroid 2-related factor 2 (Nrf2) DMXYU3I MT DTT DMXYU3I MA Activator DMXYU3I RN Recent progress in the development of small molecule Nrf2 modulators: a patent review (2012-2016).Expert Opin Ther Pat. 2017 Jul;27(7):763-785. DMXYU3I RU https://www.ncbi.nlm.nih.gov/pubmed/28454500 DMKTNBC DI DMKTNBC DMKTNBC DN Pyrazino[2,1-a]isoquinolin derivative 4 DMKTNBC MI TT3Z6Y9 DMKTNBC MN Cysteines of Keap1 (KEAP1 Cysteines) DMKTNBC MT DTT DMKTNBC MA Modulator DMKTNBC RN Recent progress in the development of small molecule Nrf2 modulators: a patent review (2012-2016).Expert Opin Ther Pat. 2017 Jul;27(7):763-785. DMKTNBC RU https://www.ncbi.nlm.nih.gov/pubmed/28454500 DMKTNBC DI DMKTNBC DMKTNBC DN Pyrazino[2,1-a]isoquinolin derivative 4 DMKTNBC MI TTA6ZN2 DMKTNBC MN Nuclear factor erythroid 2-related factor 2 (Nrf2) DMKTNBC MT DTT DMKTNBC MA Activator DMKTNBC RN Recent progress in the development of small molecule Nrf2 modulators: a patent review (2012-2016).Expert Opin Ther Pat. 2017 Jul;27(7):763-785. DMKTNBC RU https://www.ncbi.nlm.nih.gov/pubmed/28454500 DMUXQST DI DMUXQST DMUXQST DN Pyrazinylpyridine derivative 1 DMUXQST MI TT1LVF2 DMUXQST MN Cyclin-dependent kinase 9 (CDK9) DMUXQST MT DTT DMUXQST MA Inhibitor DMUXQST RN Cyclin-dependent kinase inhibitors for cancer therapy: a patent review (2009 - 2014).Expert Opin Ther Pat. 2015;25(9):953-70. DMUXQST RU https://www.ncbi.nlm.nih.gov/pubmed/26161698 DM05S2X DI DM05S2X DM05S2X DN Pyrazole and benzimidazole derivative 1 DM05S2X MI TTRZQE3 DM05S2X MN Glycogen synthase kinase-3 alpha (GSK-3A) DM05S2X MT DTT DM05S2X MA Inhibitor DM05S2X RN Glycogen synthase kinase 3 (GSK-3) inhibitors: a patent update (2014-2015).Expert Opin Ther Pat. 2017 Jun;27(6):657-666. DM05S2X RU https://www.ncbi.nlm.nih.gov/pubmed/27828716 DMKTFJ2 DI DMKTFJ2 DMKTFJ2 DN Pyrazole and thiophene derivative 1 DMKTFJ2 MI TTRA6BO DMKTFJ2 MN Bromodomain-containing protein 4 (BRD4) DMKTFJ2 MT DTT DMKTFJ2 MA Inhibitor DMKTFJ2 RN BET inhibitors in cancer therapeutics: a patent review.Expert Opin Ther Pat. 2016;26(4):505-22. DMKTFJ2 RU https://www.ncbi.nlm.nih.gov/pubmed/26924192 DMD51HM DI DMD51HM DMD51HM DN Pyrazole and thiophene derivative 2 DMD51HM MI TTRA6BO DMD51HM MN Bromodomain-containing protein 4 (BRD4) DMD51HM MT DTT DMD51HM MA Inhibitor DMD51HM RN BET inhibitors in cancer therapeutics: a patent review.Expert Opin Ther Pat. 2016;26(4):505-22. DMD51HM RU https://www.ncbi.nlm.nih.gov/pubmed/26924192 DMIKUN9 DI DMIKUN9 DMIKUN9 DN Pyrazole and thiophene derivative 3 DMIKUN9 MI TTRA6BO DMIKUN9 MN Bromodomain-containing protein 4 (BRD4) DMIKUN9 MT DTT DMIKUN9 MA Inhibitor DMIKUN9 RN BET inhibitors in cancer therapeutics: a patent review.Expert Opin Ther Pat. 2016;26(4):505-22. DMIKUN9 RU https://www.ncbi.nlm.nih.gov/pubmed/26924192 DMDETKY DI DMDETKY DMDETKY DN Pyrazole and thiophene derivative 4 DMDETKY MI TTRA6BO DMDETKY MN Bromodomain-containing protein 4 (BRD4) DMDETKY MT DTT DMDETKY MA Inhibitor DMDETKY RN BET inhibitors in cancer therapeutics: a patent review.Expert Opin Ther Pat. 2016;26(4):505-22. DMDETKY RU https://www.ncbi.nlm.nih.gov/pubmed/26924192 DM3R9PL DI DM3R9PL DM3R9PL DN Pyrazole derivative 1 DM3R9PL MI TT6OEDT DM3R9PL MN Cannabinoid receptor 1 (CB1) DM3R9PL MT DTT DM3R9PL MA Antagonist DM3R9PL RN A comprehensive patents review on cannabinoid 1 receptor antagonists as antiobesity agents. Expert Opin Ther Pat. 2015 Oct;25(10):1093-116. DM3R9PL RU https://pubmed.ncbi.nlm.nih.gov/26161824 DMH7PGU DI DMH7PGU DMH7PGU DN Pyrazole derivative 11 DMH7PGU MI TT6OEDT DMH7PGU MN Cannabinoid receptor 1 (CB1) DMH7PGU MT DTT DMH7PGU MA Antagonist DMH7PGU RN A comprehensive patents review on cannabinoid 1 receptor antagonists as antiobesity agents. Expert Opin Ther Pat. 2015 Oct;25(10):1093-116. DMH7PGU RU https://pubmed.ncbi.nlm.nih.gov/26161824 DM7LFNG DI DM7LFNG DM7LFNG DN Pyrazole derivative 12 DM7LFNG MI TT6OEDT DM7LFNG MN Cannabinoid receptor 1 (CB1) DM7LFNG MT DTT DM7LFNG MA Antagonist DM7LFNG RN A comprehensive patents review on cannabinoid 1 receptor antagonists as antiobesity agents. Expert Opin Ther Pat. 2015 Oct;25(10):1093-116. DM7LFNG RU https://pubmed.ncbi.nlm.nih.gov/26161824 DM5S3L0 DI DM5S3L0 DM5S3L0 DN Pyrazole derivative 13 DM5S3L0 MI TT6OEDT DM5S3L0 MN Cannabinoid receptor 1 (CB1) DM5S3L0 MT DTT DM5S3L0 MA Antagonist DM5S3L0 RN A comprehensive patents review on cannabinoid 1 receptor antagonists as antiobesity agents. Expert Opin Ther Pat. 2015 Oct;25(10):1093-116. DM5S3L0 RU https://pubmed.ncbi.nlm.nih.gov/26161824 DMEDXW9 DI DMEDXW9 DMEDXW9 DN Pyrazole derivative 14 DMEDXW9 MI TT6OEDT DMEDXW9 MN Cannabinoid receptor 1 (CB1) DMEDXW9 MT DTT DMEDXW9 MA Antagonist DMEDXW9 RN A comprehensive patents review on cannabinoid 1 receptor antagonists as antiobesity agents. Expert Opin Ther Pat. 2015 Oct;25(10):1093-116. DMEDXW9 RU https://pubmed.ncbi.nlm.nih.gov/26161824 DMJCX8M DI DMJCX8M DMJCX8M DN Pyrazole derivative 15 DMJCX8M MI TT6OEDT DMJCX8M MN Cannabinoid receptor 1 (CB1) DMJCX8M MT DTT DMJCX8M MA Antagonist DMJCX8M RN A comprehensive patents review on cannabinoid 1 receptor antagonists as antiobesity agents. Expert Opin Ther Pat. 2015 Oct;25(10):1093-116. DMJCX8M RU https://pubmed.ncbi.nlm.nih.gov/26161824 DM5A8F3 DI DM5A8F3 DM5A8F3 DN Pyrazole derivative 16 DM5A8F3 MI TT6OEDT DM5A8F3 MN Cannabinoid receptor 1 (CB1) DM5A8F3 MT DTT DM5A8F3 MA Antagonist DM5A8F3 RN A comprehensive patents review on cannabinoid 1 receptor antagonists as antiobesity agents. Expert Opin Ther Pat. 2015 Oct;25(10):1093-116. DM5A8F3 RU https://pubmed.ncbi.nlm.nih.gov/26161824 DM7F9V4 DI DM7F9V4 DM7F9V4 DN Pyrazole derivative 17 DM7F9V4 MI TT6OEDT DM7F9V4 MN Cannabinoid receptor 1 (CB1) DM7F9V4 MT DTT DM7F9V4 MA Antagonist DM7F9V4 RN A comprehensive patents review on cannabinoid 1 receptor antagonists as antiobesity agents. Expert Opin Ther Pat. 2015 Oct;25(10):1093-116. DM7F9V4 RU https://pubmed.ncbi.nlm.nih.gov/26161824 DMVZ8KD DI DMVZ8KD DMVZ8KD DN Pyrazole derivative 18 DMVZ8KD MI TT6OEDT DMVZ8KD MN Cannabinoid receptor 1 (CB1) DMVZ8KD MT DTT DMVZ8KD MA Antagonist DMVZ8KD RN A comprehensive patents review on cannabinoid 1 receptor antagonists as antiobesity agents. Expert Opin Ther Pat. 2015 Oct;25(10):1093-116. DMVZ8KD RU https://pubmed.ncbi.nlm.nih.gov/26161824 DMM7OR3 DI DMM7OR3 DMM7OR3 DN Pyrazole derivative 19 DMM7OR3 MI TT6OEDT DMM7OR3 MN Cannabinoid receptor 1 (CB1) DMM7OR3 MT DTT DMM7OR3 MA Antagonist DMM7OR3 RN A comprehensive patents review on cannabinoid 1 receptor antagonists as antiobesity agents. Expert Opin Ther Pat. 2015 Oct;25(10):1093-116. DMM7OR3 RU https://pubmed.ncbi.nlm.nih.gov/26161824 DMIS97T DI DMIS97T DMIS97T DN Pyrazole derivative 2 DMIS97T MI TT6OEDT DMIS97T MN Cannabinoid receptor 1 (CB1) DMIS97T MT DTT DMIS97T MA Antagonist DMIS97T RN A comprehensive patents review on cannabinoid 1 receptor antagonists as antiobesity agents. Expert Opin Ther Pat. 2015 Oct;25(10):1093-116. DMIS97T RU https://pubmed.ncbi.nlm.nih.gov/26161824 DM2HO1S DI DM2HO1S DM2HO1S DN Pyrazole derivative 20 DM2HO1S MI TT6OEDT DM2HO1S MN Cannabinoid receptor 1 (CB1) DM2HO1S MT DTT DM2HO1S MA Antagonist DM2HO1S RN A comprehensive patents review on cannabinoid 1 receptor antagonists as antiobesity agents. Expert Opin Ther Pat. 2015 Oct;25(10):1093-116. DM2HO1S RU https://pubmed.ncbi.nlm.nih.gov/26161824 DMUPNHA DI DMUPNHA DMUPNHA DN Pyrazole derivative 21 DMUPNHA MI TT6OEDT DMUPNHA MN Cannabinoid receptor 1 (CB1) DMUPNHA MT DTT DMUPNHA MA Antagonist DMUPNHA RN A comprehensive patents review on cannabinoid 1 receptor antagonists as antiobesity agents. Expert Opin Ther Pat. 2015 Oct;25(10):1093-116. DMUPNHA RU https://pubmed.ncbi.nlm.nih.gov/26161824 DMCS08K DI DMCS08K DMCS08K DN Pyrazole derivative 22 DMCS08K MI TT6OEDT DMCS08K MN Cannabinoid receptor 1 (CB1) DMCS08K MT DTT DMCS08K MA Antagonist DMCS08K RN A comprehensive patents review on cannabinoid 1 receptor antagonists as antiobesity agents. Expert Opin Ther Pat. 2015 Oct;25(10):1093-116. DMCS08K RU https://pubmed.ncbi.nlm.nih.gov/26161824 DMH2LFS DI DMH2LFS DMH2LFS DN Pyrazole derivative 23 DMH2LFS MI TT6OEDT DMH2LFS MN Cannabinoid receptor 1 (CB1) DMH2LFS MT DTT DMH2LFS MA Antagonist DMH2LFS RN A comprehensive patents review on cannabinoid 1 receptor antagonists as antiobesity agents. Expert Opin Ther Pat. 2015 Oct;25(10):1093-116. DMH2LFS RU https://pubmed.ncbi.nlm.nih.gov/26161824 DMVX2D0 DI DMVX2D0 DMVX2D0 DN Pyrazole derivative 24 DMVX2D0 MI TT6OEDT DMVX2D0 MN Cannabinoid receptor 1 (CB1) DMVX2D0 MT DTT DMVX2D0 MA Antagonist DMVX2D0 RN A comprehensive patents review on cannabinoid 1 receptor antagonists as antiobesity agents. Expert Opin Ther Pat. 2015 Oct;25(10):1093-116. DMVX2D0 RU https://pubmed.ncbi.nlm.nih.gov/26161824 DMM2RYG DI DMM2RYG DMM2RYG DN Pyrazole derivative 25 DMM2RYG MI TT6OEDT DMM2RYG MN Cannabinoid receptor 1 (CB1) DMM2RYG MT DTT DMM2RYG MA Antagonist DMM2RYG RN A comprehensive patents review on cannabinoid 1 receptor antagonists as antiobesity agents. Expert Opin Ther Pat. 2015 Oct;25(10):1093-116. DMM2RYG RU https://pubmed.ncbi.nlm.nih.gov/26161824 DMX92ZK DI DMX92ZK DMX92ZK DN Pyrazole derivative 26 DMX92ZK MI TT6OEDT DMX92ZK MN Cannabinoid receptor 1 (CB1) DMX92ZK MT DTT DMX92ZK MA Antagonist DMX92ZK RN A comprehensive patents review on cannabinoid 1 receptor antagonists as antiobesity agents. Expert Opin Ther Pat. 2015 Oct;25(10):1093-116. DMX92ZK RU https://pubmed.ncbi.nlm.nih.gov/26161824 DMDB5FH DI DMDB5FH DMDB5FH DN Pyrazole derivative 27 DMDB5FH MI TT6OEDT DMDB5FH MN Cannabinoid receptor 1 (CB1) DMDB5FH MT DTT DMDB5FH MA Antagonist DMDB5FH RN A comprehensive patents review on cannabinoid 1 receptor antagonists as antiobesity agents. Expert Opin Ther Pat. 2015 Oct;25(10):1093-116. DMDB5FH RU https://pubmed.ncbi.nlm.nih.gov/26161824 DMYEFW1 DI DMYEFW1 DMYEFW1 DN Pyrazole derivative 28 DMYEFW1 MI TT6OEDT DMYEFW1 MN Cannabinoid receptor 1 (CB1) DMYEFW1 MT DTT DMYEFW1 MA Antagonist DMYEFW1 RN A comprehensive patents review on cannabinoid 1 receptor antagonists as antiobesity agents. Expert Opin Ther Pat. 2015 Oct;25(10):1093-116. DMYEFW1 RU https://pubmed.ncbi.nlm.nih.gov/26161824 DM7DTYS DI DM7DTYS DM7DTYS DN Pyrazole derivative 29 DM7DTYS MI TT6OEDT DM7DTYS MN Cannabinoid receptor 1 (CB1) DM7DTYS MT DTT DM7DTYS MA Antagonist DM7DTYS RN A comprehensive patents review on cannabinoid 1 receptor antagonists as antiobesity agents. Expert Opin Ther Pat. 2015 Oct;25(10):1093-116. DM7DTYS RU https://pubmed.ncbi.nlm.nih.gov/26161824 DMX2NQW DI DMX2NQW DMX2NQW DN Pyrazole derivative 3 DMX2NQW MI TT6OEDT DMX2NQW MN Cannabinoid receptor 1 (CB1) DMX2NQW MT DTT DMX2NQW MA Antagonist DMX2NQW RN A comprehensive patents review on cannabinoid 1 receptor antagonists as antiobesity agents. Expert Opin Ther Pat. 2015 Oct;25(10):1093-116. DMX2NQW RU https://pubmed.ncbi.nlm.nih.gov/26161824 DMT1DJP DI DMT1DJP DMT1DJP DN Pyrazole derivative 30 DMT1DJP MI TT6OEDT DMT1DJP MN Cannabinoid receptor 1 (CB1) DMT1DJP MT DTT DMT1DJP MA Antagonist DMT1DJP RN A comprehensive patents review on cannabinoid 1 receptor antagonists as antiobesity agents. Expert Opin Ther Pat. 2015 Oct;25(10):1093-116. DMT1DJP RU https://pubmed.ncbi.nlm.nih.gov/26161824 DMDTQCG DI DMDTQCG DMDTQCG DN Pyrazole derivative 31 DMDTQCG MI TT6OEDT DMDTQCG MN Cannabinoid receptor 1 (CB1) DMDTQCG MT DTT DMDTQCG MA Antagonist DMDTQCG RN A comprehensive patents review on cannabinoid 1 receptor antagonists as antiobesity agents. Expert Opin Ther Pat. 2015 Oct;25(10):1093-116. DMDTQCG RU https://pubmed.ncbi.nlm.nih.gov/26161824 DMU59IJ DI DMU59IJ DMU59IJ DN Pyrazole derivative 32 DMU59IJ MI TT6OEDT DMU59IJ MN Cannabinoid receptor 1 (CB1) DMU59IJ MT DTT DMU59IJ MA Antagonist DMU59IJ RN A comprehensive patents review on cannabinoid 1 receptor antagonists as antiobesity agents. Expert Opin Ther Pat. 2015 Oct;25(10):1093-116. DMU59IJ RU https://pubmed.ncbi.nlm.nih.gov/26161824 DMUNLK8 DI DMUNLK8 DMUNLK8 DN Pyrazole derivative 33 DMUNLK8 MI TT6OEDT DMUNLK8 MN Cannabinoid receptor 1 (CB1) DMUNLK8 MT DTT DMUNLK8 MA Antagonist DMUNLK8 RN A comprehensive patents review on cannabinoid 1 receptor antagonists as antiobesity agents. Expert Opin Ther Pat. 2015 Oct;25(10):1093-116. DMUNLK8 RU https://pubmed.ncbi.nlm.nih.gov/26161824 DMRH2EJ DI DMRH2EJ DMRH2EJ DN Pyrazole derivative 34 DMRH2EJ MI TT6OEDT DMRH2EJ MN Cannabinoid receptor 1 (CB1) DMRH2EJ MT DTT DMRH2EJ MA Antagonist DMRH2EJ RN A comprehensive patents review on cannabinoid 1 receptor antagonists as antiobesity agents. Expert Opin Ther Pat. 2015 Oct;25(10):1093-116. DMRH2EJ RU https://pubmed.ncbi.nlm.nih.gov/26161824 DM6KROX DI DM6KROX DM6KROX DN Pyrazole derivative 35 DM6KROX MI TT6OEDT DM6KROX MN Cannabinoid receptor 1 (CB1) DM6KROX MT DTT DM6KROX MA Antagonist DM6KROX RN A comprehensive patents review on cannabinoid 1 receptor antagonists as antiobesity agents. Expert Opin Ther Pat. 2015 Oct;25(10):1093-116. DM6KROX RU https://pubmed.ncbi.nlm.nih.gov/26161824 DMSDVI1 DI DMSDVI1 DMSDVI1 DN Pyrazole derivative 36 DMSDVI1 MI TT6OEDT DMSDVI1 MN Cannabinoid receptor 1 (CB1) DMSDVI1 MT DTT DMSDVI1 MA Antagonist DMSDVI1 RN A comprehensive patents review on cannabinoid 1 receptor antagonists as antiobesity agents. Expert Opin Ther Pat. 2015 Oct;25(10):1093-116. DMSDVI1 RU https://pubmed.ncbi.nlm.nih.gov/26161824 DMZJ5FN DI DMZJ5FN DMZJ5FN DN Pyrazole derivative 37 DMZJ5FN MI TT6OEDT DMZJ5FN MN Cannabinoid receptor 1 (CB1) DMZJ5FN MT DTT DMZJ5FN MA Antagonist DMZJ5FN RN A comprehensive patents review on cannabinoid 1 receptor antagonists as antiobesity agents. Expert Opin Ther Pat. 2015 Oct;25(10):1093-116. DMZJ5FN RU https://pubmed.ncbi.nlm.nih.gov/26161824 DMPVDSC DI DMPVDSC DMPVDSC DN Pyrazole derivative 38 DMPVDSC MI TT6OEDT DMPVDSC MN Cannabinoid receptor 1 (CB1) DMPVDSC MT DTT DMPVDSC MA Antagonist DMPVDSC RN A comprehensive patents review on cannabinoid 1 receptor antagonists as antiobesity agents. Expert Opin Ther Pat. 2015 Oct;25(10):1093-116. DMPVDSC RU https://pubmed.ncbi.nlm.nih.gov/26161824 DMMGWKE DI DMMGWKE DMMGWKE DN Pyrazole derivative 39 DMMGWKE MI TT6OEDT DMMGWKE MN Cannabinoid receptor 1 (CB1) DMMGWKE MT DTT DMMGWKE MA Antagonist DMMGWKE RN A comprehensive patents review on cannabinoid 1 receptor antagonists as antiobesity agents. Expert Opin Ther Pat. 2015 Oct;25(10):1093-116. DMMGWKE RU https://pubmed.ncbi.nlm.nih.gov/26161824 DM2DK1E DI DM2DK1E DM2DK1E DN Pyrazole derivative 4 DM2DK1E MI TT6OEDT DM2DK1E MN Cannabinoid receptor 1 (CB1) DM2DK1E MT DTT DM2DK1E MA Antagonist DM2DK1E RN A comprehensive patents review on cannabinoid 1 receptor antagonists as antiobesity agents. Expert Opin Ther Pat. 2015 Oct;25(10):1093-116. DM2DK1E RU https://pubmed.ncbi.nlm.nih.gov/26161824 DM7CMV6 DI DM7CMV6 DM7CMV6 DN Pyrazole derivative 40 DM7CMV6 MI TT6OEDT DM7CMV6 MN Cannabinoid receptor 1 (CB1) DM7CMV6 MT DTT DM7CMV6 MA Antagonist DM7CMV6 RN A comprehensive patents review on cannabinoid 1 receptor antagonists as antiobesity agents. Expert Opin Ther Pat. 2015 Oct;25(10):1093-116. DM7CMV6 RU https://pubmed.ncbi.nlm.nih.gov/26161824 DMDGSKH DI DMDGSKH DMDGSKH DN Pyrazole derivative 5 DMDGSKH MI TT6OEDT DMDGSKH MN Cannabinoid receptor 1 (CB1) DMDGSKH MT DTT DMDGSKH MA Antagonist DMDGSKH RN A comprehensive patents review on cannabinoid 1 receptor antagonists as antiobesity agents. Expert Opin Ther Pat. 2015 Oct;25(10):1093-116. DMDGSKH RU https://pubmed.ncbi.nlm.nih.gov/26161824 DMMIOZ5 DI DMMIOZ5 DMMIOZ5 DN Pyrazole derivative 53 DMMIOZ5 MI TT6OEDT DMMIOZ5 MN Cannabinoid receptor 1 (CB1) DMMIOZ5 MT DTT DMMIOZ5 MA Antagonist DMMIOZ5 RN A comprehensive patents review on cannabinoid 1 receptor antagonists as antiobesity agents. Expert Opin Ther Pat. 2015 Oct;25(10):1093-116. DMMIOZ5 RU https://pubmed.ncbi.nlm.nih.gov/26161824 DM9PNTF DI DM9PNTF DM9PNTF DN Pyrazole derivative 54 DM9PNTF MI TT6OEDT DM9PNTF MN Cannabinoid receptor 1 (CB1) DM9PNTF MT DTT DM9PNTF MA Antagonist DM9PNTF RN A comprehensive patents review on cannabinoid 1 receptor antagonists as antiobesity agents. Expert Opin Ther Pat. 2015 Oct;25(10):1093-116. DM9PNTF RU https://pubmed.ncbi.nlm.nih.gov/26161824 DMZ3J78 DI DMZ3J78 DMZ3J78 DN Pyrazole derivative 57 DMZ3J78 MI TT6OEDT DMZ3J78 MN Cannabinoid receptor 1 (CB1) DMZ3J78 MT DTT DMZ3J78 MA Antagonist DMZ3J78 RN A comprehensive patents review on cannabinoid 1 receptor antagonists as antiobesity agents. Expert Opin Ther Pat. 2015 Oct;25(10):1093-116. DMZ3J78 RU https://pubmed.ncbi.nlm.nih.gov/26161824 DMZIOW0 DI DMZIOW0 DMZIOW0 DN Pyrazole derivative 58 DMZIOW0 MI TT6OEDT DMZIOW0 MN Cannabinoid receptor 1 (CB1) DMZIOW0 MT DTT DMZIOW0 MA Antagonist DMZIOW0 RN A comprehensive patents review on cannabinoid 1 receptor antagonists as antiobesity agents. Expert Opin Ther Pat. 2015 Oct;25(10):1093-116. DMZIOW0 RU https://pubmed.ncbi.nlm.nih.gov/26161824 DMXZC8K DI DMXZC8K DMXZC8K DN Pyrazole derivative 59 DMXZC8K MI TT6OEDT DMXZC8K MN Cannabinoid receptor 1 (CB1) DMXZC8K MT DTT DMXZC8K MA Antagonist DMXZC8K RN A comprehensive patents review on cannabinoid 1 receptor antagonists as antiobesity agents. Expert Opin Ther Pat. 2015 Oct;25(10):1093-116. DMXZC8K RU https://pubmed.ncbi.nlm.nih.gov/26161824 DMIDN6T DI DMIDN6T DMIDN6T DN Pyrazole derivative 6 DMIDN6T MI TT6OEDT DMIDN6T MN Cannabinoid receptor 1 (CB1) DMIDN6T MT DTT DMIDN6T MA Antagonist DMIDN6T RN A comprehensive patents review on cannabinoid 1 receptor antagonists as antiobesity agents. Expert Opin Ther Pat. 2015 Oct;25(10):1093-116. DMIDN6T RU https://pubmed.ncbi.nlm.nih.gov/26161824 DMQ08BM DI DMQ08BM DMQ08BM DN Pyrazole derivative 60 DMQ08BM MI TT6OEDT DMQ08BM MN Cannabinoid receptor 1 (CB1) DMQ08BM MT DTT DMQ08BM MA Antagonist DMQ08BM RN A comprehensive patents review on cannabinoid 1 receptor antagonists as antiobesity agents. Expert Opin Ther Pat. 2015 Oct;25(10):1093-116. DMQ08BM RU https://pubmed.ncbi.nlm.nih.gov/26161824 DMO6M1Q DI DMO6M1Q DMO6M1Q DN Pyrazole derivative 61 DMO6M1Q MI TTCZOF2 DMO6M1Q MN Pyruvate dehydrogenase kinase 1 (PDHK1) DMO6M1Q MT DTT DMO6M1Q MA Inhibitor DMO6M1Q RN PDK1 disruptors and modulators: a patent review.Expert Opin Ther Pat. 2015 May;25(5):513-37. DMO6M1Q RU https://www.ncbi.nlm.nih.gov/pubmed/25684022 DMN53R0 DI DMN53R0 DMN53R0 DN Pyrazole derivative 62 DMN53R0 MI TTH8FZW DMN53R0 MN Signal transducer and activator of transcription 3 (STAT3) DMN53R0 MT DTT DMN53R0 MA Inhibitor DMN53R0 RN A STAT inhibitor patent review: progress since 2011.Expert Opin Ther Pat. 2015;25(12):1397-421. DMN53R0 RU https://www.ncbi.nlm.nih.gov/pubmed/26394986 DMTVAJ0 DI DMTVAJ0 DMTVAJ0 DN Pyrazole derivative 63 DMTVAJ0 MI TTH8FZW DMTVAJ0 MN Signal transducer and activator of transcription 3 (STAT3) DMTVAJ0 MT DTT DMTVAJ0 MA Inhibitor DMTVAJ0 RN A STAT inhibitor patent review: progress since 2011.Expert Opin Ther Pat. 2015;25(12):1397-421. DMTVAJ0 RU https://www.ncbi.nlm.nih.gov/pubmed/26394986 DMXAURE DI DMXAURE DMXAURE DN Pyrazole derivative 64 DMXAURE MI TTH8FZW DMXAURE MN Signal transducer and activator of transcription 3 (STAT3) DMXAURE MT DTT DMXAURE MA Inhibitor DMXAURE RN A STAT inhibitor patent review: progress since 2011.Expert Opin Ther Pat. 2015;25(12):1397-421. DMXAURE RU https://www.ncbi.nlm.nih.gov/pubmed/26394986 DMYTLRJ DI DMYTLRJ DMYTLRJ DN Pyrazole derivative 65 DMYTLRJ MI TTH8FZW DMYTLRJ MN Signal transducer and activator of transcription 3 (STAT3) DMYTLRJ MT DTT DMYTLRJ MA Inhibitor DMYTLRJ RN A STAT inhibitor patent review: progress since 2011.Expert Opin Ther Pat. 2015;25(12):1397-421. DMYTLRJ RU https://www.ncbi.nlm.nih.gov/pubmed/26394986 DMBYWJI DI DMBYWJI DMBYWJI DN Pyrazole derivative 66 DMBYWJI MI TTH8FZW DMBYWJI MN Signal transducer and activator of transcription 3 (STAT3) DMBYWJI MT DTT DMBYWJI MA Inhibitor DMBYWJI RN A STAT inhibitor patent review: progress since 2011.Expert Opin Ther Pat. 2015;25(12):1397-421. DMBYWJI RU https://www.ncbi.nlm.nih.gov/pubmed/26394986 DMNZUHX DI DMNZUHX DMNZUHX DN Pyrazole derivative 67 DMNZUHX MI TTJQOD7 DMNZUHX MN 5-HT 2A receptor (HTR2A) DMNZUHX MT DTT DMNZUHX MA Antagonist DMNZUHX RN Novel serotonin receptor 2 (5-HT2R) agonists and antagonists: a patent review (2004-2014).Expert Opin Ther Pat. 2016;26(1):89-106. DMNZUHX RU https://www.ncbi.nlm.nih.gov/pubmed/26609882 DMVY0JT DI DMVY0JT DMVY0JT DN Pyrazole derivative 68 DMVY0JT MI TTJQOD7 DMVY0JT MN 5-HT 2A receptor (HTR2A) DMVY0JT MT DTT DMVY0JT MA Antagonist DMVY0JT RN Novel serotonin receptor 2 (5-HT2R) agonists and antagonists: a patent review (2004-2014).Expert Opin Ther Pat. 2016;26(1):89-106. DMVY0JT RU https://www.ncbi.nlm.nih.gov/pubmed/26609882 DMKCJE1 DI DMKCJE1 DMKCJE1 DN Pyrazole derivative 69 DMKCJE1 MI TTJQOD7 DMKCJE1 MN 5-HT 2A receptor (HTR2A) DMKCJE1 MT DTT DMKCJE1 MA Antagonist DMKCJE1 RN Novel serotonin receptor 2 (5-HT2R) agonists and antagonists: a patent review (2004-2014).Expert Opin Ther Pat. 2016;26(1):89-106. DMKCJE1 RU https://www.ncbi.nlm.nih.gov/pubmed/26609882 DMYKU0T DI DMYKU0T DMYKU0T DN Pyrazole derivative 7 DMYKU0T MI TT6OEDT DMYKU0T MN Cannabinoid receptor 1 (CB1) DMYKU0T MT DTT DMYKU0T MA Antagonist DMYKU0T RN A comprehensive patents review on cannabinoid 1 receptor antagonists as antiobesity agents. Expert Opin Ther Pat. 2015 Oct;25(10):1093-116. DMYKU0T RU https://pubmed.ncbi.nlm.nih.gov/26161824 DMR6VIG DI DMR6VIG DMR6VIG DN Pyrazole derivative 70 DMR6VIG MI TTJQOD7 DMR6VIG MN 5-HT 2A receptor (HTR2A) DMR6VIG MT DTT DMR6VIG MA Antagonist DMR6VIG RN Novel serotonin receptor 2 (5-HT2R) agonists and antagonists: a patent review (2004-2014).Expert Opin Ther Pat. 2016;26(1):89-106. DMR6VIG RU https://www.ncbi.nlm.nih.gov/pubmed/26609882 DMSNY3W DI DMSNY3W DMSNY3W DN Pyrazole derivative 71 DMSNY3W MI TTJQOD7 DMSNY3W MN 5-HT 2A receptor (HTR2A) DMSNY3W MT DTT DMSNY3W MA Antagonist DMSNY3W RN Novel serotonin receptor 2 (5-HT2R) agonists and antagonists: a patent review (2004-2014).Expert Opin Ther Pat. 2016;26(1):89-106. DMSNY3W RU https://www.ncbi.nlm.nih.gov/pubmed/26609882 DMWFTCN DI DMWFTCN DMWFTCN DN Pyrazole derivative 72 DMWFTCN MI TTJQOD7 DMWFTCN MN 5-HT 2A receptor (HTR2A) DMWFTCN MT DTT DMWFTCN MA Antagonist DMWFTCN RN Novel serotonin receptor 2 (5-HT2R) agonists and antagonists: a patent review (2004-2014).Expert Opin Ther Pat. 2016;26(1):89-106. DMWFTCN RU https://www.ncbi.nlm.nih.gov/pubmed/26609882 DMFARIK DI DMFARIK DMFARIK DN Pyrazole derivative 73 DMFARIK MI TTJQOD7 DMFARIK MN 5-HT 2A receptor (HTR2A) DMFARIK MT DTT DMFARIK MA Antagonist DMFARIK RN Novel serotonin receptor 2 (5-HT2R) agonists and antagonists: a patent review (2004-2014).Expert Opin Ther Pat. 2016;26(1):89-106. DMFARIK RU https://www.ncbi.nlm.nih.gov/pubmed/26609882 DM70QPF DI DM70QPF DM70QPF DN Pyrazole derivative 74 DM70QPF MI TTJQOD7 DM70QPF MN 5-HT 2A receptor (HTR2A) DM70QPF MT DTT DM70QPF MA Antagonist DM70QPF RN Novel serotonin receptor 2 (5-HT2R) agonists and antagonists: a patent review (2004-2014).Expert Opin Ther Pat. 2016;26(1):89-106. DM70QPF RU https://www.ncbi.nlm.nih.gov/pubmed/26609882 DMAB2EN DI DMAB2EN DMAB2EN DN Pyrazole derivative 75 DMAB2EN MI TTJQOD7 DMAB2EN MN 5-HT 2A receptor (HTR2A) DMAB2EN MT DTT DMAB2EN MA Antagonist DMAB2EN RN Novel serotonin receptor 2 (5-HT2R) agonists and antagonists: a patent review (2004-2014).Expert Opin Ther Pat. 2016;26(1):89-106. DMAB2EN RU https://www.ncbi.nlm.nih.gov/pubmed/26609882 DM6Y27J DI DM6Y27J DM6Y27J DN Pyrazole derivative 76 DM6Y27J MI TTXJ47W DM6Y27J MN Metabotropic glutamate receptor 2 (mGluR2) DM6Y27J MT DTT DM6Y27J MA Antagonist DM6Y27J RN Novel metabotropic glutamate receptor 2/3 antagonists and their therapeutic applications: a patent review (2005 - present).Expert Opin Ther Pat. 2015 Jan;25(1):69-90. DM6Y27J RU https://www.ncbi.nlm.nih.gov/pubmed/25435285 DM5E1ZJ DI DM5E1ZJ DM5E1ZJ DN Pyrazole derivative 77 DM5E1ZJ MI TTXJ47W DM5E1ZJ MN Metabotropic glutamate receptor 2 (mGluR2) DM5E1ZJ MT DTT DM5E1ZJ MA Antagonist DM5E1ZJ RN Novel metabotropic glutamate receptor 2/3 antagonists and their therapeutic applications: a patent review (2005 - present).Expert Opin Ther Pat. 2015 Jan;25(1):69-90. DM5E1ZJ RU https://www.ncbi.nlm.nih.gov/pubmed/25435285 DMMCHOW DI DMMCHOW DMMCHOW DN Pyrazole derivative 78 DMMCHOW MI TTXJ47W DMMCHOW MN Metabotropic glutamate receptor 2 (mGluR2) DMMCHOW MT DTT DMMCHOW MA Antagonist DMMCHOW RN Novel metabotropic glutamate receptor 2/3 antagonists and their therapeutic applications: a patent review (2005 - present).Expert Opin Ther Pat. 2015 Jan;25(1):69-90. DMMCHOW RU https://www.ncbi.nlm.nih.gov/pubmed/25435285 DM9JHYL DI DM9JHYL DM9JHYL DN Pyrazole derivative 79 DM9JHYL MI TTXJ47W DM9JHYL MN Metabotropic glutamate receptor 2 (mGluR2) DM9JHYL MT DTT DM9JHYL MA Antagonist DM9JHYL RN Novel metabotropic glutamate receptor 2/3 antagonists and their therapeutic applications: a patent review (2005 - present).Expert Opin Ther Pat. 2015 Jan;25(1):69-90. DM9JHYL RU https://www.ncbi.nlm.nih.gov/pubmed/25435285 DMMRTAL DI DMMRTAL DMMRTAL DN Pyrazole derivative 8 DMMRTAL MI TT6OEDT DMMRTAL MN Cannabinoid receptor 1 (CB1) DMMRTAL MT DTT DMMRTAL MA Antagonist DMMRTAL RN A comprehensive patents review on cannabinoid 1 receptor antagonists as antiobesity agents. Expert Opin Ther Pat. 2015 Oct;25(10):1093-116. DMMRTAL RU https://pubmed.ncbi.nlm.nih.gov/26161824 DMQ3TGM DI DMQ3TGM DMQ3TGM DN Pyrazole derivative 80 DMQ3TGM MI TTDP1UC DMQ3TGM MN Fatty acid amide hydrolase (FAAH) DMQ3TGM MT DTT DMQ3TGM MA Inhibitor DMQ3TGM RN A patent review of Monoacylglycerol Lipase (MAGL) inhibitors (2013-2017).Expert Opin Ther Pat. 2017 Dec;27(12):1341-1351. DMQ3TGM RU https://www.ncbi.nlm.nih.gov/pubmed/29053063 DMQ3TGM DI DMQ3TGM DMQ3TGM DN Pyrazole derivative 80 DMQ3TGM MI TTSINOV DMQ3TGM MN Monoacylglycerol lipase ABHD6 (ABHD6) DMQ3TGM MT DTT DMQ3TGM MA Inhibitor DMQ3TGM RN A patent review of Monoacylglycerol Lipase (MAGL) inhibitors (2013-2017).Expert Opin Ther Pat. 2017 Dec;27(12):1341-1351. DMQ3TGM RU https://www.ncbi.nlm.nih.gov/pubmed/29053063 DMQ3TGM DI DMQ3TGM DMQ3TGM DN Pyrazole derivative 80 DMQ3TGM MI TTZ963I DMQ3TGM MN Monoglyceride lipase (MAGL) DMQ3TGM MT DTT DMQ3TGM MA Inhibitor DMQ3TGM RN A patent review of Monoacylglycerol Lipase (MAGL) inhibitors (2013-2017).Expert Opin Ther Pat. 2017 Dec;27(12):1341-1351. DMQ3TGM RU https://www.ncbi.nlm.nih.gov/pubmed/29053063 DMWT437 DI DMWT437 DMWT437 DN Pyrazole derivative 81 DMWT437 MI TTDP1UC DMWT437 MN Fatty acid amide hydrolase (FAAH) DMWT437 MT DTT DMWT437 MA Inhibitor DMWT437 RN A patent review of Monoacylglycerol Lipase (MAGL) inhibitors (2013-2017).Expert Opin Ther Pat. 2017 Dec;27(12):1341-1351. DMWT437 RU https://www.ncbi.nlm.nih.gov/pubmed/29053063 DMWT437 DI DMWT437 DMWT437 DN Pyrazole derivative 81 DMWT437 MI TTSINOV DMWT437 MN Monoacylglycerol lipase ABHD6 (ABHD6) DMWT437 MT DTT DMWT437 MA Inhibitor DMWT437 RN A patent review of Monoacylglycerol Lipase (MAGL) inhibitors (2013-2017).Expert Opin Ther Pat. 2017 Dec;27(12):1341-1351. DMWT437 RU https://www.ncbi.nlm.nih.gov/pubmed/29053063 DMWT437 DI DMWT437 DMWT437 DN Pyrazole derivative 81 DMWT437 MI TTZ963I DMWT437 MN Monoglyceride lipase (MAGL) DMWT437 MT DTT DMWT437 MA Inhibitor DMWT437 RN A patent review of Monoacylglycerol Lipase (MAGL) inhibitors (2013-2017).Expert Opin Ther Pat. 2017 Dec;27(12):1341-1351. DMWT437 RU https://www.ncbi.nlm.nih.gov/pubmed/29053063 DMETCI3 DI DMETCI3 DMETCI3 DN Pyrazole derivative 82 DMETCI3 MI TTDP1UC DMETCI3 MN Fatty acid amide hydrolase (FAAH) DMETCI3 MT DTT DMETCI3 MA Inhibitor DMETCI3 RN A patent review of Monoacylglycerol Lipase (MAGL) inhibitors (2013-2017).Expert Opin Ther Pat. 2017 Dec;27(12):1341-1351. DMETCI3 RU https://www.ncbi.nlm.nih.gov/pubmed/29053063 DMETCI3 DI DMETCI3 DMETCI3 DN Pyrazole derivative 82 DMETCI3 MI TTSINOV DMETCI3 MN Monoacylglycerol lipase ABHD6 (ABHD6) DMETCI3 MT DTT DMETCI3 MA Inhibitor DMETCI3 RN A patent review of Monoacylglycerol Lipase (MAGL) inhibitors (2013-2017).Expert Opin Ther Pat. 2017 Dec;27(12):1341-1351. DMETCI3 RU https://www.ncbi.nlm.nih.gov/pubmed/29053063 DMETCI3 DI DMETCI3 DMETCI3 DN Pyrazole derivative 82 DMETCI3 MI TTZ963I DMETCI3 MN Monoglyceride lipase (MAGL) DMETCI3 MT DTT DMETCI3 MA Inhibitor DMETCI3 RN A patent review of Monoacylglycerol Lipase (MAGL) inhibitors (2013-2017).Expert Opin Ther Pat. 2017 Dec;27(12):1341-1351. DMETCI3 RU https://www.ncbi.nlm.nih.gov/pubmed/29053063 DMMGLOA DI DMMGLOA DMMGLOA DN Pyrazole derivative 83 DMMGLOA MI TTDP1UC DMMGLOA MN Fatty acid amide hydrolase (FAAH) DMMGLOA MT DTT DMMGLOA MA Inhibitor DMMGLOA RN A patent review of Monoacylglycerol Lipase (MAGL) inhibitors (2013-2017).Expert Opin Ther Pat. 2017 Dec;27(12):1341-1351. DMMGLOA RU https://www.ncbi.nlm.nih.gov/pubmed/29053063 DMMGLOA DI DMMGLOA DMMGLOA DN Pyrazole derivative 83 DMMGLOA MI TTZ963I DMMGLOA MN Monoglyceride lipase (MAGL) DMMGLOA MT DTT DMMGLOA MA Inhibitor DMMGLOA RN A patent review of Monoacylglycerol Lipase (MAGL) inhibitors (2013-2017).Expert Opin Ther Pat. 2017 Dec;27(12):1341-1351. DMMGLOA RU https://www.ncbi.nlm.nih.gov/pubmed/29053063 DME8Q0F DI DME8Q0F DME8Q0F DN Pyrazole derivative 84 DME8Q0F MI TTDP1UC DME8Q0F MN Fatty acid amide hydrolase (FAAH) DME8Q0F MT DTT DME8Q0F MA Inhibitor DME8Q0F RN A patent review of Monoacylglycerol Lipase (MAGL) inhibitors (2013-2017).Expert Opin Ther Pat. 2017 Dec;27(12):1341-1351. DME8Q0F RU https://www.ncbi.nlm.nih.gov/pubmed/29053063 DME8Q0F DI DME8Q0F DME8Q0F DN Pyrazole derivative 84 DME8Q0F MI TTZ963I DME8Q0F MN Monoglyceride lipase (MAGL) DME8Q0F MT DTT DME8Q0F MA Inhibitor DME8Q0F RN A patent review of Monoacylglycerol Lipase (MAGL) inhibitors (2013-2017).Expert Opin Ther Pat. 2017 Dec;27(12):1341-1351. DME8Q0F RU https://www.ncbi.nlm.nih.gov/pubmed/29053063 DMNBCKI DI DMNBCKI DMNBCKI DN Pyrazole derivative 85 DMNBCKI MI TTZ963I DMNBCKI MN Monoglyceride lipase (MAGL) DMNBCKI MT DTT DMNBCKI MA Inhibitor DMNBCKI RN A patent review of Monoacylglycerol Lipase (MAGL) inhibitors (2013-2017).Expert Opin Ther Pat. 2017 Dec;27(12):1341-1351. DMNBCKI RU https://www.ncbi.nlm.nih.gov/pubmed/29053063 DMW3PJV DI DMW3PJV DMW3PJV DN Pyrazole derivative 86 DMW3PJV MI TT5TPI6 DMW3PJV MN Opioid receptor sigma 1 (OPRS1) DMW3PJV MT DTT DMW3PJV MA Inhibitor DMW3PJV RN Are sigma modulators an effective opportunity for cancer treatment A patent overview (1996-2016).Expert Opin Ther Pat. 2017 May;27(5):565-578. DMW3PJV RU https://www.ncbi.nlm.nih.gov/pubmed/28051882 DMGZUAY DI DMGZUAY DMGZUAY DN Pyrazole derivative 87 DMGZUAY MI TTSCIM2 DMGZUAY MN Extracellular lysophospholipase D (E-NPP2) DMGZUAY MT DTT DMGZUAY MA Inhibitor DMGZUAY RN Autotaxin inhibitors: a patent review (2012-2016).Expert Opin Ther Pat. 2017 Jul;27(7):815-829. DMGZUAY RU https://www.ncbi.nlm.nih.gov/pubmed/28447479 DMVX7YT DI DMVX7YT DMVX7YT DN Pyrazole N-1 aryl and heteroaryl derivative 1 DMVX7YT MI TTKFVXR DMVX7YT MN Renal carcinoma antigen NY-REN-64 (IRAK-4) DMVX7YT MT DTT DMVX7YT MA Inhibitor DMVX7YT RN Inhibitors of interleukin-1 receptor-associated kinase 4 (IRAK4): a patent review (2012-2015).Expert Opin Ther Pat. 2016 Aug;26(8):917-32. DMVX7YT RU https://www.ncbi.nlm.nih.gov/pubmed/27310003 DMVQXZJ DI DMVQXZJ DMVQXZJ DN Pyrazole-3-carboxamide derivative 1 DMVQXZJ MI TT0K1SC DMVQXZJ MN 5-HT 2B receptor (HTR2B) DMVQXZJ MT DTT DMVQXZJ MA Antagonist DMVQXZJ RN Novel serotonin receptor 2 (5-HT2R) agonists and antagonists: a patent review (2004-2014).Expert Opin Ther Pat. 2016;26(1):89-106. DMVQXZJ RU https://www.ncbi.nlm.nih.gov/pubmed/26609882 DMGS2ET DI DMGS2ET DMGS2ET DN Pyrazoline derivative 1 DMGS2ET MI TT6OEDT DMGS2ET MN Cannabinoid receptor 1 (CB1) DMGS2ET MT DTT DMGS2ET MA Antagonist DMGS2ET RN A comprehensive patents review on cannabinoid 1 receptor antagonists as antiobesity agents. Expert Opin Ther Pat. 2015 Oct;25(10):1093-116. DMGS2ET RU https://pubmed.ncbi.nlm.nih.gov/26161824 DMCZORA DI DMCZORA DMCZORA DN Pyrazoline derivative 10 DMCZORA MI TT6OEDT DMCZORA MN Cannabinoid receptor 1 (CB1) DMCZORA MT DTT DMCZORA MA Antagonist DMCZORA RN A comprehensive patents review on cannabinoid 1 receptor antagonists as antiobesity agents. Expert Opin Ther Pat. 2015 Oct;25(10):1093-116. DMCZORA RU https://pubmed.ncbi.nlm.nih.gov/26161824 DMAB3YG DI DMAB3YG DMAB3YG DN Pyrazoline derivative 11 DMAB3YG MI TT6OEDT DMAB3YG MN Cannabinoid receptor 1 (CB1) DMAB3YG MT DTT DMAB3YG MA Antagonist DMAB3YG RN A comprehensive patents review on cannabinoid 1 receptor antagonists as antiobesity agents. Expert Opin Ther Pat. 2015 Oct;25(10):1093-116. DMAB3YG RU https://pubmed.ncbi.nlm.nih.gov/26161824 DMOA8E4 DI DMOA8E4 DMOA8E4 DN Pyrazoline derivative 2 DMOA8E4 MI TT6OEDT DMOA8E4 MN Cannabinoid receptor 1 (CB1) DMOA8E4 MT DTT DMOA8E4 MA Antagonist DMOA8E4 RN A comprehensive patents review on cannabinoid 1 receptor antagonists as antiobesity agents. Expert Opin Ther Pat. 2015 Oct;25(10):1093-116. DMOA8E4 RU https://pubmed.ncbi.nlm.nih.gov/26161824 DMGH0LQ DI DMGH0LQ DMGH0LQ DN Pyrazoline derivative 3 DMGH0LQ MI TT6OEDT DMGH0LQ MN Cannabinoid receptor 1 (CB1) DMGH0LQ MT DTT DMGH0LQ MA Antagonist DMGH0LQ RN A comprehensive patents review on cannabinoid 1 receptor antagonists as antiobesity agents. Expert Opin Ther Pat. 2015 Oct;25(10):1093-116. DMGH0LQ RU https://pubmed.ncbi.nlm.nih.gov/26161824 DMRT7I8 DI DMRT7I8 DMRT7I8 DN Pyrazoline derivative 4 DMRT7I8 MI TT6OEDT DMRT7I8 MN Cannabinoid receptor 1 (CB1) DMRT7I8 MT DTT DMRT7I8 MA Antagonist DMRT7I8 RN A comprehensive patents review on cannabinoid 1 receptor antagonists as antiobesity agents. Expert Opin Ther Pat. 2015 Oct;25(10):1093-116. DMRT7I8 RU https://pubmed.ncbi.nlm.nih.gov/26161824 DMEGS9U DI DMEGS9U DMEGS9U DN Pyrazoline derivative 5 DMEGS9U MI TT6OEDT DMEGS9U MN Cannabinoid receptor 1 (CB1) DMEGS9U MT DTT DMEGS9U MA Antagonist DMEGS9U RN A comprehensive patents review on cannabinoid 1 receptor antagonists as antiobesity agents. Expert Opin Ther Pat. 2015 Oct;25(10):1093-116. DMEGS9U RU https://pubmed.ncbi.nlm.nih.gov/26161824 DMOK7CW DI DMOK7CW DMOK7CW DN Pyrazolo[1,5-a]-1,3,5-triazine derivative 1 DMOK7CW MI TTH6V3D DMOK7CW MN Cyclin-dependent kinase 1 (CDK1) DMOK7CW MT DTT DMOK7CW MA Inhibitor DMOK7CW RN Cyclin-dependent kinase inhibitors for cancer therapy: a patent review (2009 - 2014).Expert Opin Ther Pat. 2015;25(9):953-70. DMOK7CW RU https://www.ncbi.nlm.nih.gov/pubmed/26161698 DMOK7CW DI DMOK7CW DMOK7CW DN Pyrazolo[1,5-a]-1,3,5-triazine derivative 1 DMOK7CW MI TT7HF4W DMOK7CW MN Cyclin-dependent kinase 2 (CDK2) DMOK7CW MT DTT DMOK7CW MA Inhibitor DMOK7CW RN Cyclin-dependent kinase inhibitors for cancer therapy: a patent review (2009 - 2014).Expert Opin Ther Pat. 2015;25(9):953-70. DMOK7CW RU https://www.ncbi.nlm.nih.gov/pubmed/26161698 DMOK7CW DI DMOK7CW DMOK7CW DN Pyrazolo[1,5-a]-1,3,5-triazine derivative 1 DMOK7CW MI TTL4Q97 DMOK7CW MN Cyclin-dependent kinase 5 (CDK5) DMOK7CW MT DTT DMOK7CW MA Inhibitor DMOK7CW RN Cyclin-dependent kinase inhibitors for cancer therapy: a patent review (2009 - 2014).Expert Opin Ther Pat. 2015;25(9):953-70. DMOK7CW RU https://www.ncbi.nlm.nih.gov/pubmed/26161698 DMOK7CW DI DMOK7CW DMOK7CW DN Pyrazolo[1,5-a]-1,3,5-triazine derivative 1 DMOK7CW MI TT1LVF2 DMOK7CW MN Cyclin-dependent kinase 9 (CDK9) DMOK7CW MT DTT DMOK7CW MA Inhibitor DMOK7CW RN Cyclin-dependent kinase inhibitors for cancer therapy: a patent review (2009 - 2014).Expert Opin Ther Pat. 2015;25(9):953-70. DMOK7CW RU https://www.ncbi.nlm.nih.gov/pubmed/26161698 DMH1W89 DI DMH1W89 DMH1W89 DN Pyrazolo[1,5-a]pyridine derivative 1 DMH1W89 MI TTTDVOJ DMH1W89 MN Tropomyosin-related kinase A (TrkA) DMH1W89 MT DTT DMH1W89 MA Inhibitor DMH1W89 RN Tropomyosin receptor kinase inhibitors: an updated patent review for 2010-2016 - Part II.Expert Opin Ther Pat. 2017 Jul;27(7):831-849. DMH1W89 RU https://www.ncbi.nlm.nih.gov/pubmed/28270021 DMLS827 DI DMLS827 DMLS827 DN Pyrazolo[1,5-a]pyridine derivative 2 DMLS827 MI TTTDVOJ DMLS827 MN Tropomyosin-related kinase A (TrkA) DMLS827 MT DTT DMLS827 MA Inhibitor DMLS827 RN Tropomyosin receptor kinase inhibitors: an updated patent review for 2010-2016 - Part II.Expert Opin Ther Pat. 2017 Jul;27(7):831-849. DMLS827 RU https://www.ncbi.nlm.nih.gov/pubmed/28270021 DM0FPMV DI DM0FPMV DM0FPMV DN Pyrazolo[1,5-a]pyrimidine derivative 1 DM0FPMV MI TT6OEDT DM0FPMV MN Cannabinoid receptor 1 (CB1) DM0FPMV MT DTT DM0FPMV MA Antagonist DM0FPMV RN A comprehensive patents review on cannabinoid 1 receptor antagonists as antiobesity agents. Expert Opin Ther Pat. 2015 Oct;25(10):1093-116. DM0FPMV RU https://pubmed.ncbi.nlm.nih.gov/26161824 DM07GEK DI DM07GEK DM07GEK DN Pyrazolo[1,5-a]pyrimidine derivative 10 DM07GEK MI TT6OEDT DM07GEK MN Cannabinoid receptor 1 (CB1) DM07GEK MT DTT DM07GEK MA Antagonist DM07GEK RN A comprehensive patents review on cannabinoid 1 receptor antagonists as antiobesity agents. Expert Opin Ther Pat. 2015 Oct;25(10):1093-116. DM07GEK RU https://pubmed.ncbi.nlm.nih.gov/26161824 DM0O4WR DI DM0O4WR DM0O4WR DN Pyrazolo[1,5-a]pyrimidine derivative 11 DM0O4WR MI TT6OEDT DM0O4WR MN Cannabinoid receptor 1 (CB1) DM0O4WR MT DTT DM0O4WR MA Antagonist DM0O4WR RN A comprehensive patents review on cannabinoid 1 receptor antagonists as antiobesity agents. Expert Opin Ther Pat. 2015 Oct;25(10):1093-116. DM0O4WR RU https://pubmed.ncbi.nlm.nih.gov/26161824 DMMLDUI DI DMMLDUI DMMLDUI DN Pyrazolo[1,5-a]pyrimidine derivative 12 DMMLDUI MI TT6OEDT DMMLDUI MN Cannabinoid receptor 1 (CB1) DMMLDUI MT DTT DMMLDUI MA Antagonist DMMLDUI RN A comprehensive patents review on cannabinoid 1 receptor antagonists as antiobesity agents. Expert Opin Ther Pat. 2015 Oct;25(10):1093-116. DMMLDUI RU https://pubmed.ncbi.nlm.nih.gov/26161824 DMR5O7T DI DMR5O7T DMR5O7T DN Pyrazolo[1,5-a]pyrimidine derivative 13 DMR5O7T MI TT6OEDT DMR5O7T MN Cannabinoid receptor 1 (CB1) DMR5O7T MT DTT DMR5O7T MA Antagonist DMR5O7T RN A comprehensive patents review on cannabinoid 1 receptor antagonists as antiobesity agents. Expert Opin Ther Pat. 2015 Oct;25(10):1093-116. DMR5O7T RU https://pubmed.ncbi.nlm.nih.gov/26161824 DMB6EFV DI DMB6EFV DMB6EFV DN Pyrazolo[1,5-a]pyrimidine derivative 14 DMB6EFV MI TTTDVOJ DMB6EFV MN Tropomyosin-related kinase A (TrkA) DMB6EFV MT DTT DMB6EFV MA Inhibitor DMB6EFV RN Tropomyosin receptor kinase inhibitors: an updated patent review for 2010-2016 - Part I.Expert Opin Ther Pat. 2017 Jun;27(6):733-751. DMB6EFV RU https://www.ncbi.nlm.nih.gov/pubmed/28270010 DMAZI3D DI DMAZI3D DMAZI3D DN Pyrazolo[1,5-a]pyrimidine derivative 15 DMAZI3D MI TTTDVOJ DMAZI3D MN Tropomyosin-related kinase A (TrkA) DMAZI3D MT DTT DMAZI3D MA Inhibitor DMAZI3D RN Tropomyosin receptor kinase inhibitors: an updated patent review for 2010-2016 - Part I.Expert Opin Ther Pat. 2017 Jun;27(6):733-751. DMAZI3D RU https://www.ncbi.nlm.nih.gov/pubmed/28270010 DMTYN2D DI DMTYN2D DMTYN2D DN Pyrazolo[1,5-a]pyrimidine derivative 16 DMTYN2D MI TTTDVOJ DMTYN2D MN Tropomyosin-related kinase A (TrkA) DMTYN2D MT DTT DMTYN2D MA Inhibitor DMTYN2D RN Tropomyosin receptor kinase inhibitors: an updated patent review for 2010-2016 - Part I.Expert Opin Ther Pat. 2017 Jun;27(6):733-751. DMTYN2D RU https://www.ncbi.nlm.nih.gov/pubmed/28270010 DMNIER3 DI DMNIER3 DMNIER3 DN Pyrazolo[1,5-a]pyrimidine derivative 17 DMNIER3 MI TTTDVOJ DMNIER3 MN Tropomyosin-related kinase A (TrkA) DMNIER3 MT DTT DMNIER3 MA Inhibitor DMNIER3 RN Tropomyosin receptor kinase inhibitors: an updated patent review for 2010-2016 - Part I.Expert Opin Ther Pat. 2017 Jun;27(6):733-751. DMNIER3 RU https://www.ncbi.nlm.nih.gov/pubmed/28270010 DMVEP6Y DI DMVEP6Y DMVEP6Y DN Pyrazolo[1,5-a]pyrimidine derivative 18 DMVEP6Y MI TTTDVOJ DMVEP6Y MN Tropomyosin-related kinase A (TrkA) DMVEP6Y MT DTT DMVEP6Y MA Inhibitor DMVEP6Y RN Tropomyosin receptor kinase inhibitors: an updated patent review for 2010-2016 - Part I.Expert Opin Ther Pat. 2017 Jun;27(6):733-751. DMVEP6Y RU https://www.ncbi.nlm.nih.gov/pubmed/28270010 DMFV36A DI DMFV36A DMFV36A DN Pyrazolo[1,5-a]pyrimidine derivative 19 DMFV36A MI TTTDVOJ DMFV36A MN Tropomyosin-related kinase A (TrkA) DMFV36A MT DTT DMFV36A MA Inhibitor DMFV36A RN Tropomyosin receptor kinase inhibitors: an updated patent review for 2010-2016 - Part I.Expert Opin Ther Pat. 2017 Jun;27(6):733-751. DMFV36A RU https://www.ncbi.nlm.nih.gov/pubmed/28270010 DMO3MJ7 DI DMO3MJ7 DMO3MJ7 DN Pyrazolo[1,5-a]pyrimidine derivative 2 DMO3MJ7 MI TT6OEDT DMO3MJ7 MN Cannabinoid receptor 1 (CB1) DMO3MJ7 MT DTT DMO3MJ7 MA Antagonist DMO3MJ7 RN A comprehensive patents review on cannabinoid 1 receptor antagonists as antiobesity agents. Expert Opin Ther Pat. 2015 Oct;25(10):1093-116. DMO3MJ7 RU https://pubmed.ncbi.nlm.nih.gov/26161824 DMJLU8R DI DMJLU8R DMJLU8R DN Pyrazolo[1,5-a]pyrimidine derivative 20 DMJLU8R MI TTTDVOJ DMJLU8R MN Tropomyosin-related kinase A (TrkA) DMJLU8R MT DTT DMJLU8R MA Inhibitor DMJLU8R RN Tropomyosin receptor kinase inhibitors: an updated patent review for 2010-2016 - Part I.Expert Opin Ther Pat. 2017 Jun;27(6):733-751. DMJLU8R RU https://www.ncbi.nlm.nih.gov/pubmed/28270010 DMWNZTI DI DMWNZTI DMWNZTI DN Pyrazolo[1,5-a]pyrimidine derivative 21 DMWNZTI MI TTTDVOJ DMWNZTI MN Tropomyosin-related kinase A (TrkA) DMWNZTI MT DTT DMWNZTI MA Inhibitor DMWNZTI RN Tropomyosin receptor kinase inhibitors: an updated patent review for 2010-2016 - Part I.Expert Opin Ther Pat. 2017 Jun;27(6):733-751. DMWNZTI RU https://www.ncbi.nlm.nih.gov/pubmed/28270010 DMG5CXB DI DMG5CXB DMG5CXB DN Pyrazolo[1,5-a]pyrimidine derivative 22 DMG5CXB MI TTTDVOJ DMG5CXB MN Tropomyosin-related kinase A (TrkA) DMG5CXB MT DTT DMG5CXB MA Inhibitor DMG5CXB RN Tropomyosin receptor kinase inhibitors: an updated patent review for 2010-2016 - Part I.Expert Opin Ther Pat. 2017 Jun;27(6):733-751. DMG5CXB RU https://www.ncbi.nlm.nih.gov/pubmed/28270010 DMQVLP8 DI DMQVLP8 DMQVLP8 DN Pyrazolo[1,5-a]pyrimidine derivative 23 DMQVLP8 MI TTTDVOJ DMQVLP8 MN Tropomyosin-related kinase A (TrkA) DMQVLP8 MT DTT DMQVLP8 MA Inhibitor DMQVLP8 RN Tropomyosin receptor kinase inhibitors: an updated patent review for 2010-2016 - Part I.Expert Opin Ther Pat. 2017 Jun;27(6):733-751. DMQVLP8 RU https://www.ncbi.nlm.nih.gov/pubmed/28270010 DMT4ZP9 DI DMT4ZP9 DMT4ZP9 DN Pyrazolo[1,5-a]pyrimidine derivative 24 DMT4ZP9 MI TTTDVOJ DMT4ZP9 MN Tropomyosin-related kinase A (TrkA) DMT4ZP9 MT DTT DMT4ZP9 MA Inhibitor DMT4ZP9 RN Tropomyosin receptor kinase inhibitors: an updated patent review for 2010-2016 - Part I.Expert Opin Ther Pat. 2017 Jun;27(6):733-751. DMT4ZP9 RU https://www.ncbi.nlm.nih.gov/pubmed/28270010 DMKE7YO DI DMKE7YO DMKE7YO DN Pyrazolo[1,5-a]pyrimidine derivative 25 DMKE7YO MI TTTDVOJ DMKE7YO MN Tropomyosin-related kinase A (TrkA) DMKE7YO MT DTT DMKE7YO MA Inhibitor DMKE7YO RN Tropomyosin receptor kinase inhibitors: an updated patent review for 2010-2016 - Part I.Expert Opin Ther Pat. 2017 Jun;27(6):733-751. DMKE7YO RU https://www.ncbi.nlm.nih.gov/pubmed/28270010 DMGZ59Q DI DMGZ59Q DMGZ59Q DN Pyrazolo[1,5-a]pyrimidine derivative 26 DMGZ59Q MI TTTDVOJ DMGZ59Q MN Tropomyosin-related kinase A (TrkA) DMGZ59Q MT DTT DMGZ59Q MA Inhibitor DMGZ59Q RN Tropomyosin receptor kinase inhibitors: an updated patent review for 2010-2016 - Part I.Expert Opin Ther Pat. 2017 Jun;27(6):733-751. DMGZ59Q RU https://www.ncbi.nlm.nih.gov/pubmed/28270010 DM9OXAB DI DM9OXAB DM9OXAB DN Pyrazolo[1,5-a]pyrimidine derivative 27 DM9OXAB MI TTTDVOJ DM9OXAB MN Tropomyosin-related kinase A (TrkA) DM9OXAB MT DTT DM9OXAB MA Inhibitor DM9OXAB RN Tropomyosin receptor kinase inhibitors: an updated patent review for 2010-2016 - Part I.Expert Opin Ther Pat. 2017 Jun;27(6):733-751. DM9OXAB RU https://www.ncbi.nlm.nih.gov/pubmed/28270010 DMG1RNL DI DMG1RNL DMG1RNL DN Pyrazolo[1,5-a]pyrimidine derivative 28 DMG1RNL MI TTF8P9I DMG1RNL MN Diacylglycerol acyltransferase 1 (DGAT1) DMG1RNL MT DTT DMG1RNL MA Inhibitor DMG1RNL RN Acyltransferase inhibitors: a patent review (2010-present).Expert Opin Ther Pat. 2015 Feb;25(2):145-58. DMG1RNL RU https://www.ncbi.nlm.nih.gov/pubmed/25470667 DMCT6QW DI DMCT6QW DMCT6QW DN Pyrazolo[1,5-a]pyrimidine derivative 29 DMCT6QW MI TTF8P9I DMCT6QW MN Diacylglycerol acyltransferase 1 (DGAT1) DMCT6QW MT DTT DMCT6QW MA Inhibitor DMCT6QW RN Acyltransferase inhibitors: a patent review (2010-present).Expert Opin Ther Pat. 2015 Feb;25(2):145-58. DMCT6QW RU https://www.ncbi.nlm.nih.gov/pubmed/25470667 DMHTV47 DI DMHTV47 DMHTV47 DN Pyrazolo[1,5-a]pyrimidine derivative 3 DMHTV47 MI TT6OEDT DMHTV47 MN Cannabinoid receptor 1 (CB1) DMHTV47 MT DTT DMHTV47 MA Antagonist DMHTV47 RN A comprehensive patents review on cannabinoid 1 receptor antagonists as antiobesity agents. Expert Opin Ther Pat. 2015 Oct;25(10):1093-116. DMHTV47 RU https://pubmed.ncbi.nlm.nih.gov/26161824 DMCAVF0 DI DMCAVF0 DMCAVF0 DN Pyrazolo[1,5-a]pyrimidine derivative 4 DMCAVF0 MI TT6OEDT DMCAVF0 MN Cannabinoid receptor 1 (CB1) DMCAVF0 MT DTT DMCAVF0 MA Antagonist DMCAVF0 RN A comprehensive patents review on cannabinoid 1 receptor antagonists as antiobesity agents. Expert Opin Ther Pat. 2015 Oct;25(10):1093-116. DMCAVF0 RU https://pubmed.ncbi.nlm.nih.gov/26161824 DM3UBG2 DI DM3UBG2 DM3UBG2 DN Pyrazolo[1,5-a]pyrimidine derivative 5 DM3UBG2 MI TT6OEDT DM3UBG2 MN Cannabinoid receptor 1 (CB1) DM3UBG2 MT DTT DM3UBG2 MA Antagonist DM3UBG2 RN A comprehensive patents review on cannabinoid 1 receptor antagonists as antiobesity agents. Expert Opin Ther Pat. 2015 Oct;25(10):1093-116. DM3UBG2 RU https://pubmed.ncbi.nlm.nih.gov/26161824 DM5E1KS DI DM5E1KS DM5E1KS DN Pyrazolo[1,5-a]pyrimidine derivative 6 DM5E1KS MI TT6OEDT DM5E1KS MN Cannabinoid receptor 1 (CB1) DM5E1KS MT DTT DM5E1KS MA Antagonist DM5E1KS RN A comprehensive patents review on cannabinoid 1 receptor antagonists as antiobesity agents. Expert Opin Ther Pat. 2015 Oct;25(10):1093-116. DM5E1KS RU https://pubmed.ncbi.nlm.nih.gov/26161824 DMFUSPR DI DMFUSPR DMFUSPR DN Pyrazolo[1,5-a]pyrimidine derivative 7 DMFUSPR MI TT6OEDT DMFUSPR MN Cannabinoid receptor 1 (CB1) DMFUSPR MT DTT DMFUSPR MA Antagonist DMFUSPR RN A comprehensive patents review on cannabinoid 1 receptor antagonists as antiobesity agents. Expert Opin Ther Pat. 2015 Oct;25(10):1093-116. DMFUSPR RU https://pubmed.ncbi.nlm.nih.gov/26161824 DMTQNYZ DI DMTQNYZ DMTQNYZ DN Pyrazolo[1,5-a]pyrimidine derivative 8 DMTQNYZ MI TT6OEDT DMTQNYZ MN Cannabinoid receptor 1 (CB1) DMTQNYZ MT DTT DMTQNYZ MA Antagonist DMTQNYZ RN A comprehensive patents review on cannabinoid 1 receptor antagonists as antiobesity agents. Expert Opin Ther Pat. 2015 Oct;25(10):1093-116. DMTQNYZ RU https://pubmed.ncbi.nlm.nih.gov/26161824 DMXAW2S DI DMXAW2S DMXAW2S DN Pyrazolo[1,5-a]pyrimidine derivative 9 DMXAW2S MI TT6OEDT DMXAW2S MN Cannabinoid receptor 1 (CB1) DMXAW2S MT DTT DMXAW2S MA Antagonist DMXAW2S RN A comprehensive patents review on cannabinoid 1 receptor antagonists as antiobesity agents. Expert Opin Ther Pat. 2015 Oct;25(10):1093-116. DMXAW2S RU https://pubmed.ncbi.nlm.nih.gov/26161824 DMQHCDZ DI DMQHCDZ DMQHCDZ DN Pyrazolo[3,4-c]pyridine derivative 1 DMQHCDZ MI TTSCIM2 DMQHCDZ MN Extracellular lysophospholipase D (E-NPP2) DMQHCDZ MT DTT DMQHCDZ MA Inhibitor DMQHCDZ RN Autotaxin inhibitors: a patent review (2012-2016).Expert Opin Ther Pat. 2017 Jul;27(7):815-829. DMQHCDZ RU https://www.ncbi.nlm.nih.gov/pubmed/28447479 DMT57C4 DI DMT57C4 DMT57C4 DN Pyrazolo[3,4-d]pyrimidine derivative 1 DMT57C4 MI TTJGW1Z DMT57C4 MN Phosphodiesterase 2A (PDE2A) DMT57C4 MT DTT DMT57C4 MA Inhibitor DMT57C4 RN Towards selective phosphodiesterase 2A (PDE2A) inhibitors: a patent review (2010 - present).Expert Opin Ther Pat. 2016 Aug;26(8):933-46. DMT57C4 RU https://www.ncbi.nlm.nih.gov/pubmed/27321640 DMO054V DI DMO054V DMO054V DN Pyrazolo[3,4-d]pyrimidine derivative 2 DMO054V MI TTJGW1Z DMO054V MN Phosphodiesterase 2A (PDE2A) DMO054V MT DTT DMO054V MA Inhibitor DMO054V RN Towards selective phosphodiesterase 2A (PDE2A) inhibitors: a patent review (2010 - present).Expert Opin Ther Pat. 2016 Aug;26(8):933-46. DMO054V RU https://www.ncbi.nlm.nih.gov/pubmed/27321640 DMRKVP9 DI DMRKVP9 DMRKVP9 DN Pyrazolo[3,4-d]pyrimidine derivative 3 DMRKVP9 MI TTJGW1Z DMRKVP9 MN Phosphodiesterase 2A (PDE2A) DMRKVP9 MT DTT DMRKVP9 MA Inhibitor DMRKVP9 RN Towards selective phosphodiesterase 2A (PDE2A) inhibitors: a patent review (2010 - present).Expert Opin Ther Pat. 2016 Aug;26(8):933-46. DMRKVP9 RU https://www.ncbi.nlm.nih.gov/pubmed/27321640 DMGFAS6 DI DMGFAS6 DMGFAS6 DN Pyrazolo[3,4-d]pyrimidine derivative 4 DMGFAS6 MI TTJGW1Z DMGFAS6 MN Phosphodiesterase 2A (PDE2A) DMGFAS6 MT DTT DMGFAS6 MA Inhibitor DMGFAS6 RN Towards selective phosphodiesterase 2A (PDE2A) inhibitors: a patent review (2010 - present).Expert Opin Ther Pat. 2016 Aug;26(8):933-46. DMGFAS6 RU https://www.ncbi.nlm.nih.gov/pubmed/27321640 DMIH0F4 DI DMIH0F4 DMIH0F4 DN Pyrazolo[3,4-d]pyrimidine derivative 5 DMIH0F4 MI TT4DXQT DMIH0F4 MN Proto-oncogene c-Ret (RET) DMIH0F4 MT DTT DMIH0F4 MA Inhibitor DMIH0F4 RN RET kinase inhibitors: a review of recent patents (2012-2015).Expert Opin Ther Pat. 2017 Jan;27(1):91-99. DMIH0F4 RU https://www.ncbi.nlm.nih.gov/pubmed/27646564 DMCTWVY DI DMCTWVY DMCTWVY DN Pyrazolo[3,4-d]pyrimidine derivative 6 DMCTWVY MI TT4DXQT DMCTWVY MN Proto-oncogene c-Ret (RET) DMCTWVY MT DTT DMCTWVY MA Inhibitor DMCTWVY RN RET kinase inhibitors: a review of recent patents (2012-2015).Expert Opin Ther Pat. 2017 Jan;27(1):91-99. DMCTWVY RU https://www.ncbi.nlm.nih.gov/pubmed/27646564 DM4GF58 DI DM4GF58 DM4GF58 DN Pyrazolo[3,4-d]pyrimidine derivative 7 DM4GF58 MI TT4DXQT DM4GF58 MN Proto-oncogene c-Ret (RET) DM4GF58 MT DTT DM4GF58 MA Inhibitor DM4GF58 RN RET kinase inhibitors: a review of recent patents (2012-2015).Expert Opin Ther Pat. 2017 Jan;27(1):91-99. DM4GF58 RU https://www.ncbi.nlm.nih.gov/pubmed/27646564 DM89GKE DI DM89GKE DM89GKE DN Pyrazolo[3,4-d]pyrimidine derivative 8 DM89GKE MI TT4DXQT DM89GKE MN Proto-oncogene c-Ret (RET) DM89GKE MT DTT DM89GKE MA Inhibitor DM89GKE RN RET kinase inhibitors: a review of recent patents (2012-2015).Expert Opin Ther Pat. 2017 Jan;27(1):91-99. DM89GKE RU https://www.ncbi.nlm.nih.gov/pubmed/27646564 DMHRUIZ DI DMHRUIZ DMHRUIZ DN Pyrazolo[4,3-c]pyridine derivative 1 DMHRUIZ MI TTTDVOJ DMHRUIZ MN Tropomyosin-related kinase A (TrkA) DMHRUIZ MT DTT DMHRUIZ MA Inhibitor DMHRUIZ RN Tropomyosin receptor kinase inhibitors: an updated patent review for 2010-2016 - Part II.Expert Opin Ther Pat. 2017 Jul;27(7):831-849. DMHRUIZ RU https://www.ncbi.nlm.nih.gov/pubmed/28270021 DMCDFLQ DI DMCDFLQ DMCDFLQ DN Pyrazolo[4,3-c]pyridine derivative 2 DMCDFLQ MI TTNDSC3 DMCDFLQ MN B lymphocyte kinase (BLK) DMCDFLQ MT DTT DMCDFLQ MA Inhibitor DMCDFLQ RN Inhibitors of JAK-family kinases: an update on the patent literature 2013-2015, part 1.Expert Opin Ther Pat. 2017 Feb;27(2):127-143. DMCDFLQ RU https://www.ncbi.nlm.nih.gov/pubmed/27774824 DMCDFLQ DI DMCDFLQ DMCDFLQ DN Pyrazolo[4,3-c]pyridine derivative 2 DMCDFLQ MI TT6DM01 DMCDFLQ MN Janus kinase 1 (JAK-1) DMCDFLQ MT DTT DMCDFLQ MA Inhibitor DMCDFLQ RN Inhibitors of JAK-family kinases: an update on the patent literature 2013-2015, part 1.Expert Opin Ther Pat. 2017 Feb;27(2):127-143. DMCDFLQ RU https://www.ncbi.nlm.nih.gov/pubmed/27774824 DMCDFLQ DI DMCDFLQ DMCDFLQ DN Pyrazolo[4,3-c]pyridine derivative 2 DMCDFLQ MI TTRMX3V DMCDFLQ MN Janus kinase 2 (JAK-2) DMCDFLQ MT DTT DMCDFLQ MA Inhibitor DMCDFLQ RN Inhibitors of JAK-family kinases: an update on the patent literature 2013-2015, part 1.Expert Opin Ther Pat. 2017 Feb;27(2):127-143. DMCDFLQ RU https://www.ncbi.nlm.nih.gov/pubmed/27774824 DMCDFLQ DI DMCDFLQ DMCDFLQ DN Pyrazolo[4,3-c]pyridine derivative 2 DMCDFLQ MI TTT7PJU DMCDFLQ MN Janus kinase 3 (JAK-3) DMCDFLQ MT DTT DMCDFLQ MA Inhibitor DMCDFLQ RN Inhibitors of JAK-family kinases: an update on the patent literature 2013-2015, part 1.Expert Opin Ther Pat. 2017 Feb;27(2):127-143. DMCDFLQ RU https://www.ncbi.nlm.nih.gov/pubmed/27774824 DMCDFLQ DI DMCDFLQ DMCDFLQ DN Pyrazolo[4,3-c]pyridine derivative 2 DMCDFLQ MI TT3C80U DMCDFLQ MN T-cell-specific kinase (ITK) DMCDFLQ MT DTT DMCDFLQ MA Inhibitor DMCDFLQ RN Inhibitors of JAK-family kinases: an update on the patent literature 2013-2015, part 1.Expert Opin Ther Pat. 2017 Feb;27(2):127-143. DMCDFLQ RU https://www.ncbi.nlm.nih.gov/pubmed/27774824 DMCDFLQ DI DMCDFLQ DMCDFLQ DN Pyrazolo[4,3-c]pyridine derivative 2 DMCDFLQ MI TTBYWP2 DMCDFLQ MN TYK2 tyrosine kinase (TYK2) DMCDFLQ MT DTT DMCDFLQ MA Inhibitor DMCDFLQ RN Inhibitors of JAK-family kinases: an update on the patent literature 2013-2015, part 1.Expert Opin Ther Pat. 2017 Feb;27(2):127-143. DMCDFLQ RU https://www.ncbi.nlm.nih.gov/pubmed/27774824 DMCDFLQ DI DMCDFLQ DMCDFLQ DN Pyrazolo[4,3-c]pyridine derivative 2 DMCDFLQ MI TTGM6VW DMCDFLQ MN Tyrosine-protein kinase BTK (ATK) DMCDFLQ MT DTT DMCDFLQ MA Inhibitor DMCDFLQ RN Inhibitors of JAK-family kinases: an update on the patent literature 2013-2015, part 1.Expert Opin Ther Pat. 2017 Feb;27(2):127-143. DMCDFLQ RU https://www.ncbi.nlm.nih.gov/pubmed/27774824 DMCDFLQ DI DMCDFLQ DMCDFLQ DN Pyrazolo[4,3-c]pyridine derivative 2 DMCDFLQ MI TT1ZV49 DMCDFLQ MN Tyrosine-protein kinase Tec (PSCTK4) DMCDFLQ MT DTT DMCDFLQ MA Inhibitor DMCDFLQ RN Inhibitors of JAK-family kinases: an update on the patent literature 2013-2015, part 1.Expert Opin Ther Pat. 2017 Feb;27(2):127-143. DMCDFLQ RU https://www.ncbi.nlm.nih.gov/pubmed/27774824 DMTM82B DI DMTM82B DMTM82B DN Pyrazolo[4,3-h]quinazoline-3-carboxamide derivative 1 DMTM82B MI TTTDVOJ DMTM82B MN Tropomyosin-related kinase A (TrkA) DMTM82B MT DTT DMTM82B MA Inhibitor DMTM82B RN Tropomyosin receptor kinase inhibitors: an updated patent review for 2010-2016 - Part II.Expert Opin Ther Pat. 2017 Jul;27(7):831-849. DMTM82B RU https://www.ncbi.nlm.nih.gov/pubmed/28270021 DMRN2QI DI DMRN2QI DMRN2QI DN Pyrazolodiazepine derivative 1 DMRN2QI MI TT2F4OL DMRN2QI MN Tissue transglutaminase (TG2) DMRN2QI MT DTT DMRN2QI MA Inhibitor DMRN2QI RN Transglutaminase inhibitors: a patent review.Expert Opin Ther Pat. 2016;26(1):49-63. DMRN2QI RU https://www.ncbi.nlm.nih.gov/pubmed/26560530 DMKYX7J DI DMKYX7J DMKYX7J DN Pyrazolodihydropyridine derivative 1 DMKYX7J MI TTRZQE3 DMKYX7J MN Glycogen synthase kinase-3 alpha (GSK-3A) DMKYX7J MT DTT DMKYX7J MA Inhibitor DMKYX7J RN Glycogen synthase kinase 3 (GSK-3) inhibitors: a patent update (2014-2015).Expert Opin Ther Pat. 2017 Jun;27(6):657-666. DMKYX7J RU https://www.ncbi.nlm.nih.gov/pubmed/27828716 DMY03RZ DI DMY03RZ DMY03RZ DN Pyrazolopyridine derivative 1 DMY03RZ MI TTT7PJU DMY03RZ MN Janus kinase 3 (JAK-3) DMY03RZ MT DTT DMY03RZ MA Inhibitor DMY03RZ RN Inhibitors of JAK-family kinases: an update on the patent literature 2013-2015, part 2.Expert Opin Ther Pat. 2017 Feb;27(2):145-161. DMY03RZ RU https://www.ncbi.nlm.nih.gov/pubmed/27774822 DMCJVLR DI DMCJVLR DMCJVLR DN Pyrazolopyridine derivative 2 DMCJVLR MI TTT7PJU DMCJVLR MN Janus kinase 3 (JAK-3) DMCJVLR MT DTT DMCJVLR MA Inhibitor DMCJVLR RN Inhibitors of JAK-family kinases: an update on the patent literature 2013-2015, part 2.Expert Opin Ther Pat. 2017 Feb;27(2):145-161. DMCJVLR RU https://www.ncbi.nlm.nih.gov/pubmed/27774822 DM2VQ4P DI DM2VQ4P DM2VQ4P DN Pyrazolopyridine derivative 3 DM2VQ4P MI TT6DM01 DM2VQ4P MN Janus kinase 1 (JAK-1) DM2VQ4P MT DTT DM2VQ4P MA Inhibitor DM2VQ4P RN Inhibitors of JAK-family kinases: an update on the patent literature 2013-2015, part 2.Expert Opin Ther Pat. 2017 Feb;27(2):145-161. DM2VQ4P RU https://www.ncbi.nlm.nih.gov/pubmed/27774822 DM2VQ4P DI DM2VQ4P DM2VQ4P DN Pyrazolopyridine derivative 3 DM2VQ4P MI TTRMX3V DM2VQ4P MN Janus kinase 2 (JAK-2) DM2VQ4P MT DTT DM2VQ4P MA Inhibitor DM2VQ4P RN Inhibitors of JAK-family kinases: an update on the patent literature 2013-2015, part 2.Expert Opin Ther Pat. 2017 Feb;27(2):145-161. DM2VQ4P RU https://www.ncbi.nlm.nih.gov/pubmed/27774822 DM2VQ4P DI DM2VQ4P DM2VQ4P DN Pyrazolopyridine derivative 3 DM2VQ4P MI TTT7PJU DM2VQ4P MN Janus kinase 3 (JAK-3) DM2VQ4P MT DTT DM2VQ4P MA Inhibitor DM2VQ4P RN Inhibitors of JAK-family kinases: an update on the patent literature 2013-2015, part 2.Expert Opin Ther Pat. 2017 Feb;27(2):145-161. DM2VQ4P RU https://www.ncbi.nlm.nih.gov/pubmed/27774822 DM2VQ4P DI DM2VQ4P DM2VQ4P DN Pyrazolopyridine derivative 3 DM2VQ4P MI TTBYWP2 DM2VQ4P MN TYK2 tyrosine kinase (TYK2) DM2VQ4P MT DTT DM2VQ4P MA Inhibitor DM2VQ4P RN Inhibitors of JAK-family kinases: an update on the patent literature 2013-2015, part 2.Expert Opin Ther Pat. 2017 Feb;27(2):145-161. DM2VQ4P RU https://www.ncbi.nlm.nih.gov/pubmed/27774822 DMX7RWV DI DMX7RWV DMX7RWV DN Pyrazolopyridine derivative 4 DMX7RWV MI TT6DM01 DMX7RWV MN Janus kinase 1 (JAK-1) DMX7RWV MT DTT DMX7RWV MA Inhibitor DMX7RWV RN Inhibitors of JAK-family kinases: an update on the patent literature 2013-2015, part 2.Expert Opin Ther Pat. 2017 Feb;27(2):145-161. DMX7RWV RU https://www.ncbi.nlm.nih.gov/pubmed/27774822 DMX7RWV DI DMX7RWV DMX7RWV DN Pyrazolopyridine derivative 4 DMX7RWV MI TTRMX3V DMX7RWV MN Janus kinase 2 (JAK-2) DMX7RWV MT DTT DMX7RWV MA Inhibitor DMX7RWV RN Inhibitors of JAK-family kinases: an update on the patent literature 2013-2015, part 2.Expert Opin Ther Pat. 2017 Feb;27(2):145-161. DMX7RWV RU https://www.ncbi.nlm.nih.gov/pubmed/27774822 DMX7RWV DI DMX7RWV DMX7RWV DN Pyrazolopyridine derivative 4 DMX7RWV MI TTT7PJU DMX7RWV MN Janus kinase 3 (JAK-3) DMX7RWV MT DTT DMX7RWV MA Inhibitor DMX7RWV RN Inhibitors of JAK-family kinases: an update on the patent literature 2013-2015, part 2.Expert Opin Ther Pat. 2017 Feb;27(2):145-161. DMX7RWV RU https://www.ncbi.nlm.nih.gov/pubmed/27774822 DMTZCLG DI DMTZCLG DMTZCLG DN Pyrazolopyridine derivative 5 DMTZCLG MI TTBYWP2 DMTZCLG MN TYK2 tyrosine kinase (TYK2) DMTZCLG MT DTT DMTZCLG MA Inhibitor DMTZCLG RN Inhibitors of JAK-family kinases: an update on the patent literature 2013-2015, part 2.Expert Opin Ther Pat. 2017 Feb;27(2):145-161. DMTZCLG RU https://www.ncbi.nlm.nih.gov/pubmed/27774822 DM5OH8D DI DM5OH8D DM5OH8D DN Pyrazolopyridine derivative 6 DM5OH8D MI TTRMX3V DM5OH8D MN Janus kinase 2 (JAK-2) DM5OH8D MT DTT DM5OH8D MA Inhibitor DM5OH8D RN Inhibitors of JAK-family kinases: an update on the patent literature 2013-2015, part 1.Expert Opin Ther Pat. 2017 Feb;27(2):127-143. DM5OH8D RU https://www.ncbi.nlm.nih.gov/pubmed/27774824 DM5OH8D DI DM5OH8D DM5OH8D DN Pyrazolopyridine derivative 6 DM5OH8D MI TTT7PJU DM5OH8D MN Janus kinase 3 (JAK-3) DM5OH8D MT DTT DM5OH8D MA Inhibitor DM5OH8D RN Inhibitors of JAK-family kinases: an update on the patent literature 2013-2015, part 1.Expert Opin Ther Pat. 2017 Feb;27(2):127-143. DM5OH8D RU https://www.ncbi.nlm.nih.gov/pubmed/27774824 DMCTQ9O DI DMCTQ9O DMCTQ9O DN Pyrazolopyridine derivative 7 DMCTQ9O MI TTRMX3V DMCTQ9O MN Janus kinase 2 (JAK-2) DMCTQ9O MT DTT DMCTQ9O MA Inhibitor DMCTQ9O RN Inhibitors of JAK-family kinases: an update on the patent literature 2013-2015, part 1.Expert Opin Ther Pat. 2017 Feb;27(2):127-143. DMCTQ9O RU https://www.ncbi.nlm.nih.gov/pubmed/27774824 DMCTQ9O DI DMCTQ9O DMCTQ9O DN Pyrazolopyridine derivative 7 DMCTQ9O MI TTT7PJU DMCTQ9O MN Janus kinase 3 (JAK-3) DMCTQ9O MT DTT DMCTQ9O MA Inhibitor DMCTQ9O RN Inhibitors of JAK-family kinases: an update on the patent literature 2013-2015, part 1.Expert Opin Ther Pat. 2017 Feb;27(2):127-143. DMCTQ9O RU https://www.ncbi.nlm.nih.gov/pubmed/27774824 DMSR5FO DI DMSR5FO DMSR5FO DN Pyrazolopyridines and imidazopyridine derivative 1 DMSR5FO MI TTCZOF2 DMSR5FO MN Pyruvate dehydrogenase kinase 1 (PDHK1) DMSR5FO MT DTT DMSR5FO MA Inhibitor DMSR5FO RN PDK1 disruptors and modulators: a patent review.Expert Opin Ther Pat. 2015 May;25(5):513-37. DMSR5FO RU https://www.ncbi.nlm.nih.gov/pubmed/25684022 DMRAS8L DI DMRAS8L DMRAS8L DN Pyrazolopyrimidine acetamide analog 1 DMRAS8L MI TTPTXIN DMRAS8L MN Translocator protein (TSPO) DMRAS8L MT DTT DMRAS8L MA Ligand DMRAS8L RN Translocator protein (TSPO) ligands for the diagnosis or treatment of neurodegenerative diseases: a patent review (2010-2015; part 1).Expert Opin Ther Pat. 2016 Nov;26(11):1325-1351. DMRAS8L RU https://www.ncbi.nlm.nih.gov/pubmed/27607364 DMK7F3A DI DMK7F3A DMK7F3A DN Pyrazolopyrimidine acetamide analog 2 DMK7F3A MI TTPTXIN DMK7F3A MN Translocator protein (TSPO) DMK7F3A MT DTT DMK7F3A MA Ligand DMK7F3A RN Translocator protein (TSPO) ligands for the diagnosis or treatment of neurodegenerative diseases: a patent review (2010-2015; part 1).Expert Opin Ther Pat. 2016 Nov;26(11):1325-1351. DMK7F3A RU https://www.ncbi.nlm.nih.gov/pubmed/27607364 DM6TB4Z DI DM6TB4Z DM6TB4Z DN Pyrazolopyrimidine and thienopyrimidine amide derivative 1 DM6TB4Z MI TTXAJWN DM6TB4Z MN IL-1 receptor-associated kinase 1 (IRAK1) DM6TB4Z MT DTT DM6TB4Z MA Inhibitor DM6TB4Z RN Inhibitors of interleukin-1 receptor-associated kinase 4 (IRAK4): a patent review (2012-2015).Expert Opin Ther Pat. 2016 Aug;26(8):917-32. DM6TB4Z RU https://www.ncbi.nlm.nih.gov/pubmed/27310003 DM6TB4Z DI DM6TB4Z DM6TB4Z DN Pyrazolopyrimidine and thienopyrimidine amide derivative 1 DM6TB4Z MI TTKFVXR DM6TB4Z MN Renal carcinoma antigen NY-REN-64 (IRAK-4) DM6TB4Z MT DTT DM6TB4Z MA Inhibitor DM6TB4Z RN Inhibitors of interleukin-1 receptor-associated kinase 4 (IRAK4): a patent review (2012-2015).Expert Opin Ther Pat. 2016 Aug;26(8):917-32. DM6TB4Z RU https://www.ncbi.nlm.nih.gov/pubmed/27310003 DMFUNH4 DI DMFUNH4 DMFUNH4 DN Pyrazolopyrimidine and thienopyrimidine amide derivative 2 DMFUNH4 MI TTXAJWN DMFUNH4 MN IL-1 receptor-associated kinase 1 (IRAK1) DMFUNH4 MT DTT DMFUNH4 MA Inhibitor DMFUNH4 RN Inhibitors of interleukin-1 receptor-associated kinase 4 (IRAK4): a patent review (2012-2015).Expert Opin Ther Pat. 2016 Aug;26(8):917-32. DMFUNH4 RU https://www.ncbi.nlm.nih.gov/pubmed/27310003 DMFUNH4 DI DMFUNH4 DMFUNH4 DN Pyrazolopyrimidine and thienopyrimidine amide derivative 2 DMFUNH4 MI TTKFVXR DMFUNH4 MN Renal carcinoma antigen NY-REN-64 (IRAK-4) DMFUNH4 MT DTT DMFUNH4 MA Inhibitor DMFUNH4 RN Inhibitors of interleukin-1 receptor-associated kinase 4 (IRAK4): a patent review (2012-2015).Expert Opin Ther Pat. 2016 Aug;26(8):917-32. DMFUNH4 RU https://www.ncbi.nlm.nih.gov/pubmed/27310003 DMHO3NB DI DMHO3NB DMHO3NB DN Pyrazolopyrimidine derivative 1 DMHO3NB MI TTHS256 DMHO3NB MN Metabotropic glutamate receptor 5 (mGluR5) DMHO3NB MT DTT DMHO3NB MA Modulator DMHO3NB RN mGlu5 negative allosteric modulators: a patent review (2013 - 2016).Expert Opin Ther Pat. 2017 Jun;27(6):691-706. DMHO3NB RU https://www.ncbi.nlm.nih.gov/pubmed/28067079 DMZEP5X DI DMZEP5X DMZEP5X DN Pyrazolopyrimidine derivative 2 DMZEP5X MI TTHS256 DMZEP5X MN Metabotropic glutamate receptor 5 (mGluR5) DMZEP5X MT DTT DMZEP5X MA Modulator DMZEP5X RN mGlu5 negative allosteric modulators: a patent review (2013 - 2016).Expert Opin Ther Pat. 2017 Jun;27(6):691-706. DMZEP5X RU https://www.ncbi.nlm.nih.gov/pubmed/28067079 DMI0J7D DI DMI0J7D DMI0J7D DN Pyrazolopyrimidine derivative 3 DMI0J7D MI TTHS256 DMI0J7D MN Metabotropic glutamate receptor 5 (mGluR5) DMI0J7D MT DTT DMI0J7D MA Modulator DMI0J7D RN mGlu5 negative allosteric modulators: a patent review (2013 - 2016).Expert Opin Ther Pat. 2017 Jun;27(6):691-706. DMI0J7D RU https://www.ncbi.nlm.nih.gov/pubmed/28067079 DM7XSHK DI DM7XSHK DM7XSHK DN Pyrazolopyrimidine derivative 4 DM7XSHK MI TTHS256 DM7XSHK MN Metabotropic glutamate receptor 5 (mGluR5) DM7XSHK MT DTT DM7XSHK MA Modulator DM7XSHK RN mGlu5 negative allosteric modulators: a patent review (2013 - 2016).Expert Opin Ther Pat. 2017 Jun;27(6):691-706. DM7XSHK RU https://www.ncbi.nlm.nih.gov/pubmed/28067079 DMVUSF3 DI DMVUSF3 DMVUSF3 DN Pyrazolopyrimidine derivative 5 DMVUSF3 MI TTHS256 DMVUSF3 MN Metabotropic glutamate receptor 5 (mGluR5) DMVUSF3 MT DTT DMVUSF3 MA Modulator DMVUSF3 RN mGlu5 negative allosteric modulators: a patent review (2013 - 2016).Expert Opin Ther Pat. 2017 Jun;27(6):691-706. DMVUSF3 RU https://www.ncbi.nlm.nih.gov/pubmed/28067079 DMG8V31 DI DMG8V31 DMG8V31 DN Pyrazolopyrimidine derivative 6 DMG8V31 MI TTHS256 DMG8V31 MN Metabotropic glutamate receptor 5 (mGluR5) DMG8V31 MT DTT DMG8V31 MA Modulator DMG8V31 RN mGlu5 negative allosteric modulators: a patent review (2013 - 2016).Expert Opin Ther Pat. 2017 Jun;27(6):691-706. DMG8V31 RU https://www.ncbi.nlm.nih.gov/pubmed/28067079 DMTD3C1 DI DMTD3C1 DMTD3C1 DN Pyrazolo-triazine derivative 1 DMTD3C1 MI TTQYF7G DMTD3C1 MN Cyclin-dependent kinase 7 (CDK7) DMTD3C1 MT DTT DMTD3C1 MA Inhibitor DMTD3C1 RN Cyclin-dependent kinase inhibitors for cancer therapy: a patent review (2009 - 2014).Expert Opin Ther Pat. 2015;25(9):953-70. DMTD3C1 RU https://www.ncbi.nlm.nih.gov/pubmed/26161698 DML6V78 DI DML6V78 DML6V78 DN Pyrazolo-triazine derivative 2 DML6V78 MI TT7HF4W DML6V78 MN Cyclin-dependent kinase 2 (CDK2) DML6V78 MT DTT DML6V78 MA Inhibitor DML6V78 RN Cyclin-dependent kinase inhibitors for cancer therapy: a patent review (2009 - 2014).Expert Opin Ther Pat. 2015;25(9):953-70. DML6V78 RU https://www.ncbi.nlm.nih.gov/pubmed/26161698 DML6V78 DI DML6V78 DML6V78 DN Pyrazolo-triazine derivative 2 DML6V78 MI TTQYF7G DML6V78 MN Cyclin-dependent kinase 7 (CDK7) DML6V78 MT DTT DML6V78 MA Inhibitor DML6V78 RN Cyclin-dependent kinase inhibitors for cancer therapy: a patent review (2009 - 2014).Expert Opin Ther Pat. 2015;25(9):953-70. DML6V78 RU https://www.ncbi.nlm.nih.gov/pubmed/26161698 DMKJ3PC DI DMKJ3PC DMKJ3PC DN Pyridazin-3(2H)-one derivative 1 DMKJ3PC MI TT9JNIC DMKJ3PC MN Histamine H3 receptor (H3R) DMKJ3PC MT DTT DMKJ3PC MA Inverse agonist DMKJ3PC RN Progress in the development of histamine H3 receptor antagonists/inverse agonists: a patent review (2013-2017).Expert Opin Ther Pat. 2018 Mar;28(3):175-196. DMKJ3PC RU https://www.ncbi.nlm.nih.gov/pubmed/29334795 DMF7MEB DI DMF7MEB DMF7MEB DN Pyridazinone derivative 1 DMF7MEB MI TT473XN DMF7MEB MN P2X purinoceptor 7 (P2RX7) DMF7MEB MT DTT DMF7MEB MA Antagonist DMF7MEB RN P2X7 receptor antagonists: a patent review (2010-2015).Expert Opin Ther Pat. 2017 Mar;27(3):257-267. DMF7MEB RU https://www.ncbi.nlm.nih.gov/pubmed/27724045 DM3GU7K DI DM3GU7K DM3GU7K DN Pyridic ketone derivative 1 DM3GU7K MI TTIDAPM DM3GU7K MN ERK activator kinase 1 (MEK1) DM3GU7K MT DTT DM3GU7K MA Inhibitor DM3GU7K RN MEK inhibitors in oncology: a patent review (2015-Present).Expert Opin Ther Pat. 2017 Aug;27(8):887-906. DM3GU7K RU https://www.ncbi.nlm.nih.gov/pubmed/28594589 DM3GU7K DI DM3GU7K DM3GU7K DN Pyridic ketone derivative 1 DM3GU7K MI TTTW2NY DM3GU7K MN ERK activator kinase 2 (MEK2) DM3GU7K MT DTT DM3GU7K MA Inhibitor DM3GU7K RN MEK inhibitors in oncology: a patent review (2015-Present).Expert Opin Ther Pat. 2017 Aug;27(8):887-906. DM3GU7K RU https://www.ncbi.nlm.nih.gov/pubmed/28594589 DMGEYJW DI DMGEYJW DMGEYJW DN Pyridine and pyrimidine derivative 1 DMGEYJW MI TTSCIM2 DMGEYJW MN Extracellular lysophospholipase D (E-NPP2) DMGEYJW MT DTT DMGEYJW MA Inhibitor DMGEYJW RN Autotaxin inhibitors: a patent review (2012-2016).Expert Opin Ther Pat. 2017 Jul;27(7):815-829. DMGEYJW RU https://www.ncbi.nlm.nih.gov/pubmed/28447479 DMSGF8T DI DMSGF8T DMSGF8T DN Pyridine derivative 1 DMSGF8T MI TTZJYKH DMSGF8T MN Indoleamine 2,3-dioxygenase 1 (IDO1) DMSGF8T MT DTT DMSGF8T MA Inhibitor DMSGF8T RN A patent review of IDO1 inhibitors for cancer.Expert Opin Ther Pat. 2018 Apr;28(4):317-330. DMSGF8T RU https://www.ncbi.nlm.nih.gov/pubmed/29473428 DMVL2G3 DI DMVL2G3 DMVL2G3 DN Pyridine derivative 10 DMVL2G3 MI TTOHSBA DMVL2G3 MN Vascular endothelial growth factor A (VEGFA) DMVL2G3 MT DTT DMVL2G3 MA Inhibitor DMVL2G3 RN VEGFR-2 inhibitors and the therapeutic applications thereof: a patent review (2012-2016).Expert Opin Ther Pat. 2017 Sep;27(9):987-1004. DMVL2G3 RU https://www.ncbi.nlm.nih.gov/pubmed/28621580 DMF9VMW DI DMF9VMW DMF9VMW DN Pyridine derivative 11 DMF9VMW MI TTOHSBA DMF9VMW MN Vascular endothelial growth factor A (VEGFA) DMF9VMW MT DTT DMF9VMW MA Inhibitor DMF9VMW RN VEGFR-2 inhibitors and the therapeutic applications thereof: a patent review (2012-2016).Expert Opin Ther Pat. 2017 Sep;27(9):987-1004. DMF9VMW RU https://www.ncbi.nlm.nih.gov/pubmed/28621580 DM8KBHX DI DM8KBHX DM8KBHX DN Pyridine derivative 12 DM8KBHX MI TTHS256 DM8KBHX MN Metabotropic glutamate receptor 5 (mGluR5) DM8KBHX MT DTT DM8KBHX MA Modulator DM8KBHX RN mGlu5 negative allosteric modulators: a patent review (2013 - 2016).Expert Opin Ther Pat. 2017 Jun;27(6):691-706. DM8KBHX RU https://www.ncbi.nlm.nih.gov/pubmed/28067079 DMX8RGH DI DMX8RGH DMX8RGH DN Pyridine derivative 13 DMX8RGH MI TTHS256 DMX8RGH MN Metabotropic glutamate receptor 5 (mGluR5) DMX8RGH MT DTT DMX8RGH MA Modulator DMX8RGH RN mGlu5 negative allosteric modulators: a patent review (2013 - 2016).Expert Opin Ther Pat. 2017 Jun;27(6):691-706. DMX8RGH RU https://www.ncbi.nlm.nih.gov/pubmed/28067079 DM7JCM6 DI DM7JCM6 DM7JCM6 DN Pyridine derivative 14 DM7JCM6 MI TTHS256 DM7JCM6 MN Metabotropic glutamate receptor 5 (mGluR5) DM7JCM6 MT DTT DM7JCM6 MA Modulator DM7JCM6 RN mGlu5 negative allosteric modulators: a patent review (2013 - 2016).Expert Opin Ther Pat. 2017 Jun;27(6):691-706. DM7JCM6 RU https://www.ncbi.nlm.nih.gov/pubmed/28067079 DMGBR43 DI DMGBR43 DMGBR43 DN Pyridine derivative 15 DMGBR43 MI TTHS256 DMGBR43 MN Metabotropic glutamate receptor 5 (mGluR5) DMGBR43 MT DTT DMGBR43 MA Modulator DMGBR43 RN mGlu5 negative allosteric modulators: a patent review (2013 - 2016).Expert Opin Ther Pat. 2017 Jun;27(6):691-706. DMGBR43 RU https://www.ncbi.nlm.nih.gov/pubmed/28067079 DMICZLS DI DMICZLS DMICZLS DN Pyridine derivative 16 DMICZLS MI TTHS256 DMICZLS MN Metabotropic glutamate receptor 5 (mGluR5) DMICZLS MT DTT DMICZLS MA Modulator DMICZLS RN mGlu5 negative allosteric modulators: a patent review (2013 - 2016).Expert Opin Ther Pat. 2017 Jun;27(6):691-706. DMICZLS RU https://www.ncbi.nlm.nih.gov/pubmed/28067079 DMLC5WA DI DMLC5WA DMLC5WA DN Pyridine derivative 17 DMLC5WA MI TTHS256 DMLC5WA MN Metabotropic glutamate receptor 5 (mGluR5) DMLC5WA MT DTT DMLC5WA MA Modulator DMLC5WA RN mGlu5 negative allosteric modulators: a patent review (2013 - 2016).Expert Opin Ther Pat. 2017 Jun;27(6):691-706. DMLC5WA RU https://www.ncbi.nlm.nih.gov/pubmed/28067079 DMBZMYT DI DMBZMYT DMBZMYT DN Pyridine derivative 18 DMBZMYT MI TTGJCWZ DMBZMYT MN Fms-like tyrosine kinase 3 (FLT-3) DMBZMYT MT DTT DMBZMYT MA Inhibitor DMBZMYT RN RET kinase inhibitors: a review of recent patents (2012-2015).Expert Opin Ther Pat. 2017 Jan;27(1):91-99. DMBZMYT RU https://www.ncbi.nlm.nih.gov/pubmed/27646564 DMBZMYT DI DMBZMYT DMBZMYT DN Pyridine derivative 18 DMBZMYT MI TT7MRDV DMBZMYT MN Macrophage colony-stimulating factor 1 receptor (CSF1R) DMBZMYT MT DTT DMBZMYT MA Inhibitor DMBZMYT RN RET kinase inhibitors: a review of recent patents (2012-2015).Expert Opin Ther Pat. 2017 Jan;27(1):91-99. DMBZMYT RU https://www.ncbi.nlm.nih.gov/pubmed/27646564 DMBZMYT DI DMBZMYT DMBZMYT DN Pyridine derivative 18 DMBZMYT MI TT8FYO9 DMBZMYT MN Platelet-derived growth factor receptor alpha (PDGFRA) DMBZMYT MT DTT DMBZMYT MA Inhibitor DMBZMYT RN RET kinase inhibitors: a review of recent patents (2012-2015).Expert Opin Ther Pat. 2017 Jan;27(1):91-99. DMBZMYT RU https://www.ncbi.nlm.nih.gov/pubmed/27646564 DMBZMYT DI DMBZMYT DMBZMYT DN Pyridine derivative 18 DMBZMYT MI TTI7421 DMBZMYT MN Platelet-derived growth factor receptor beta (PDGFRB) DMBZMYT MT DTT DMBZMYT MA Inhibitor DMBZMYT RN RET kinase inhibitors: a review of recent patents (2012-2015).Expert Opin Ther Pat. 2017 Jan;27(1):91-99. DMBZMYT RU https://www.ncbi.nlm.nih.gov/pubmed/27646564 DMBZMYT DI DMBZMYT DMBZMYT DN Pyridine derivative 18 DMBZMYT MI TT4DXQT DMBZMYT MN Proto-oncogene c-Ret (RET) DMBZMYT MT DTT DMBZMYT MA Inhibitor DMBZMYT RN RET kinase inhibitors: a review of recent patents (2012-2015).Expert Opin Ther Pat. 2017 Jan;27(1):91-99. DMBZMYT RU https://www.ncbi.nlm.nih.gov/pubmed/27646564 DMBZMYT DI DMBZMYT DMBZMYT DN Pyridine derivative 18 DMBZMYT MI TT6PKBN DMBZMYT MN Proto-oncogene c-Src (SRC) DMBZMYT MT DTT DMBZMYT MA Inhibitor DMBZMYT RN RET kinase inhibitors: a review of recent patents (2012-2015).Expert Opin Ther Pat. 2017 Jan;27(1):91-99. DMBZMYT RU https://www.ncbi.nlm.nih.gov/pubmed/27646564 DMBZMYT DI DMBZMYT DMBZMYT DN Pyridine derivative 18 DMBZMYT MI TTX41N9 DMBZMYT MN Tyrosine-protein kinase Kit (KIT) DMBZMYT MT DTT DMBZMYT MA Inhibitor DMBZMYT RN RET kinase inhibitors: a review of recent patents (2012-2015).Expert Opin Ther Pat. 2017 Jan;27(1):91-99. DMBZMYT RU https://www.ncbi.nlm.nih.gov/pubmed/27646564 DMBZMYT DI DMBZMYT DMBZMYT DN Pyridine derivative 18 DMBZMYT MI TTUTJGQ DMBZMYT MN Vascular endothelial growth factor receptor 2 (KDR) DMBZMYT MT DTT DMBZMYT MA Inhibitor DMBZMYT RN RET kinase inhibitors: a review of recent patents (2012-2015).Expert Opin Ther Pat. 2017 Jan;27(1):91-99. DMBZMYT RU https://www.ncbi.nlm.nih.gov/pubmed/27646564 DMXYT40 DI DMXYT40 DMXYT40 DN Pyridine derivative 19 DMXYT40 MI TT7MRDV DMXYT40 MN Macrophage colony-stimulating factor 1 receptor (CSF1R) DMXYT40 MT DTT DMXYT40 MA Inhibitor DMXYT40 RN RET kinase inhibitors: a review of recent patents (2012-2015).Expert Opin Ther Pat. 2017 Jan;27(1):91-99. DMXYT40 RU https://www.ncbi.nlm.nih.gov/pubmed/27646564 DMXYT40 DI DMXYT40 DMXYT40 DN Pyridine derivative 19 DMXYT40 MI TT8FYO9 DMXYT40 MN Platelet-derived growth factor receptor alpha (PDGFRA) DMXYT40 MT DTT DMXYT40 MA Inhibitor DMXYT40 RN RET kinase inhibitors: a review of recent patents (2012-2015).Expert Opin Ther Pat. 2017 Jan;27(1):91-99. DMXYT40 RU https://www.ncbi.nlm.nih.gov/pubmed/27646564 DMXYT40 DI DMXYT40 DMXYT40 DN Pyridine derivative 19 DMXYT40 MI TT4DXQT DMXYT40 MN Proto-oncogene c-Ret (RET) DMXYT40 MT DTT DMXYT40 MA Inhibitor DMXYT40 RN RET kinase inhibitors: a review of recent patents (2012-2015).Expert Opin Ther Pat. 2017 Jan;27(1):91-99. DMXYT40 RU https://www.ncbi.nlm.nih.gov/pubmed/27646564 DMXYT40 DI DMXYT40 DMXYT40 DN Pyridine derivative 19 DMXYT40 MI TTX41N9 DMXYT40 MN Tyrosine-protein kinase Kit (KIT) DMXYT40 MT DTT DMXYT40 MA Inhibitor DMXYT40 RN RET kinase inhibitors: a review of recent patents (2012-2015).Expert Opin Ther Pat. 2017 Jan;27(1):91-99. DMXYT40 RU https://www.ncbi.nlm.nih.gov/pubmed/27646564 DMGSUIV DI DMGSUIV DMGSUIV DN Pyridine derivative 2 DMGSUIV MI TTOHSBA DMGSUIV MN Vascular endothelial growth factor A (VEGFA) DMGSUIV MT DTT DMGSUIV MA Inhibitor DMGSUIV RN VEGFR-2 inhibitors and the therapeutic applications thereof: a patent review (2012-2016).Expert Opin Ther Pat. 2017 Sep;27(9):987-1004. DMGSUIV RU https://www.ncbi.nlm.nih.gov/pubmed/28621580 DMAOF0W DI DMAOF0W DMAOF0W DN Pyridine derivative 20 DMAOF0W MI TT7MRDV DMAOF0W MN Macrophage colony-stimulating factor 1 receptor (CSF1R) DMAOF0W MT DTT DMAOF0W MA Inhibitor DMAOF0W RN RET kinase inhibitors: a review of recent patents (2012-2015).Expert Opin Ther Pat. 2017 Jan;27(1):91-99. DMAOF0W RU https://www.ncbi.nlm.nih.gov/pubmed/27646564 DMAOF0W DI DMAOF0W DMAOF0W DN Pyridine derivative 20 DMAOF0W MI TT8FYO9 DMAOF0W MN Platelet-derived growth factor receptor alpha (PDGFRA) DMAOF0W MT DTT DMAOF0W MA Inhibitor DMAOF0W RN RET kinase inhibitors: a review of recent patents (2012-2015).Expert Opin Ther Pat. 2017 Jan;27(1):91-99. DMAOF0W RU https://www.ncbi.nlm.nih.gov/pubmed/27646564 DMAOF0W DI DMAOF0W DMAOF0W DN Pyridine derivative 20 DMAOF0W MI TT4DXQT DMAOF0W MN Proto-oncogene c-Ret (RET) DMAOF0W MT DTT DMAOF0W MA Inhibitor DMAOF0W RN RET kinase inhibitors: a review of recent patents (2012-2015).Expert Opin Ther Pat. 2017 Jan;27(1):91-99. DMAOF0W RU https://www.ncbi.nlm.nih.gov/pubmed/27646564 DMAOF0W DI DMAOF0W DMAOF0W DN Pyridine derivative 20 DMAOF0W MI TTX41N9 DMAOF0W MN Tyrosine-protein kinase Kit (KIT) DMAOF0W MT DTT DMAOF0W MA Inhibitor DMAOF0W RN RET kinase inhibitors: a review of recent patents (2012-2015).Expert Opin Ther Pat. 2017 Jan;27(1):91-99. DMAOF0W RU https://www.ncbi.nlm.nih.gov/pubmed/27646564 DMF3907 DI DMF3907 DMF3907 DN Pyridine derivative 21 DMF3907 MI TT7MRDV DMF3907 MN Macrophage colony-stimulating factor 1 receptor (CSF1R) DMF3907 MT DTT DMF3907 MA Inhibitor DMF3907 RN RET kinase inhibitors: a review of recent patents (2012-2015).Expert Opin Ther Pat. 2017 Jan;27(1):91-99. DMF3907 RU https://www.ncbi.nlm.nih.gov/pubmed/27646564 DMF3907 DI DMF3907 DMF3907 DN Pyridine derivative 21 DMF3907 MI TT8FYO9 DMF3907 MN Platelet-derived growth factor receptor alpha (PDGFRA) DMF3907 MT DTT DMF3907 MA Inhibitor DMF3907 RN RET kinase inhibitors: a review of recent patents (2012-2015).Expert Opin Ther Pat. 2017 Jan;27(1):91-99. DMF3907 RU https://www.ncbi.nlm.nih.gov/pubmed/27646564 DMF3907 DI DMF3907 DMF3907 DN Pyridine derivative 21 DMF3907 MI TT4DXQT DMF3907 MN Proto-oncogene c-Ret (RET) DMF3907 MT DTT DMF3907 MA Inhibitor DMF3907 RN RET kinase inhibitors: a review of recent patents (2012-2015).Expert Opin Ther Pat. 2017 Jan;27(1):91-99. DMF3907 RU https://www.ncbi.nlm.nih.gov/pubmed/27646564 DMF3907 DI DMF3907 DMF3907 DN Pyridine derivative 21 DMF3907 MI TTX41N9 DMF3907 MN Tyrosine-protein kinase Kit (KIT) DMF3907 MT DTT DMF3907 MA Inhibitor DMF3907 RN RET kinase inhibitors: a review of recent patents (2012-2015).Expert Opin Ther Pat. 2017 Jan;27(1):91-99. DMF3907 RU https://www.ncbi.nlm.nih.gov/pubmed/27646564 DMSIERF DI DMSIERF DMSIERF DN Pyridine derivative 22 DMSIERF MI TT7MRDV DMSIERF MN Macrophage colony-stimulating factor 1 receptor (CSF1R) DMSIERF MT DTT DMSIERF MA Inhibitor DMSIERF RN RET kinase inhibitors: a review of recent patents (2012-2015).Expert Opin Ther Pat. 2017 Jan;27(1):91-99. DMSIERF RU https://www.ncbi.nlm.nih.gov/pubmed/27646564 DMSIERF DI DMSIERF DMSIERF DN Pyridine derivative 22 DMSIERF MI TT8FYO9 DMSIERF MN Platelet-derived growth factor receptor alpha (PDGFRA) DMSIERF MT DTT DMSIERF MA Inhibitor DMSIERF RN RET kinase inhibitors: a review of recent patents (2012-2015).Expert Opin Ther Pat. 2017 Jan;27(1):91-99. DMSIERF RU https://www.ncbi.nlm.nih.gov/pubmed/27646564 DMSIERF DI DMSIERF DMSIERF DN Pyridine derivative 22 DMSIERF MI TT4DXQT DMSIERF MN Proto-oncogene c-Ret (RET) DMSIERF MT DTT DMSIERF MA Inhibitor DMSIERF RN RET kinase inhibitors: a review of recent patents (2012-2015).Expert Opin Ther Pat. 2017 Jan;27(1):91-99. DMSIERF RU https://www.ncbi.nlm.nih.gov/pubmed/27646564 DMSIERF DI DMSIERF DMSIERF DN Pyridine derivative 22 DMSIERF MI TTX41N9 DMSIERF MN Tyrosine-protein kinase Kit (KIT) DMSIERF MT DTT DMSIERF MA Inhibitor DMSIERF RN RET kinase inhibitors: a review of recent patents (2012-2015).Expert Opin Ther Pat. 2017 Jan;27(1):91-99. DMSIERF RU https://www.ncbi.nlm.nih.gov/pubmed/27646564 DMFALQN DI DMFALQN DMFALQN DN Pyridine derivative 3 DMFALQN MI TTOHSBA DMFALQN MN Vascular endothelial growth factor A (VEGFA) DMFALQN MT DTT DMFALQN MA Inhibitor DMFALQN RN VEGFR-2 inhibitors and the therapeutic applications thereof: a patent review (2012-2016).Expert Opin Ther Pat. 2017 Sep;27(9):987-1004. DMFALQN RU https://www.ncbi.nlm.nih.gov/pubmed/28621580 DM6N8T3 DI DM6N8T3 DM6N8T3 DN Pyridine derivative 4 DM6N8T3 MI TTOHSBA DM6N8T3 MN Vascular endothelial growth factor A (VEGFA) DM6N8T3 MT DTT DM6N8T3 MA Inhibitor DM6N8T3 RN VEGFR-2 inhibitors and the therapeutic applications thereof: a patent review (2012-2016).Expert Opin Ther Pat. 2017 Sep;27(9):987-1004. DM6N8T3 RU https://www.ncbi.nlm.nih.gov/pubmed/28621580 DMXP6W1 DI DMXP6W1 DMXP6W1 DN Pyridine derivative 5 DMXP6W1 MI TTOHSBA DMXP6W1 MN Vascular endothelial growth factor A (VEGFA) DMXP6W1 MT DTT DMXP6W1 MA Inhibitor DMXP6W1 RN VEGFR-2 inhibitors and the therapeutic applications thereof: a patent review (2012-2016).Expert Opin Ther Pat. 2017 Sep;27(9):987-1004. DMXP6W1 RU https://www.ncbi.nlm.nih.gov/pubmed/28621580 DM8NBM0 DI DM8NBM0 DM8NBM0 DN Pyridine derivative 6 DM8NBM0 MI TTOHSBA DM8NBM0 MN Vascular endothelial growth factor A (VEGFA) DM8NBM0 MT DTT DM8NBM0 MA Inhibitor DM8NBM0 RN VEGFR-2 inhibitors and the therapeutic applications thereof: a patent review (2012-2016).Expert Opin Ther Pat. 2017 Sep;27(9):987-1004. DM8NBM0 RU https://www.ncbi.nlm.nih.gov/pubmed/28621580 DMYT1QN DI DMYT1QN DMYT1QN DN Pyridine derivative 7 DMYT1QN MI TTOHSBA DMYT1QN MN Vascular endothelial growth factor A (VEGFA) DMYT1QN MT DTT DMYT1QN MA Inhibitor DMYT1QN RN VEGFR-2 inhibitors and the therapeutic applications thereof: a patent review (2012-2016).Expert Opin Ther Pat. 2017 Sep;27(9):987-1004. DMYT1QN RU https://www.ncbi.nlm.nih.gov/pubmed/28621580 DMITVUY DI DMITVUY DMITVUY DN Pyridine derivative 8 DMITVUY MI TTOHSBA DMITVUY MN Vascular endothelial growth factor A (VEGFA) DMITVUY MT DTT DMITVUY MA Inhibitor DMITVUY RN VEGFR-2 inhibitors and the therapeutic applications thereof: a patent review (2012-2016).Expert Opin Ther Pat. 2017 Sep;27(9):987-1004. DMITVUY RU https://www.ncbi.nlm.nih.gov/pubmed/28621580 DMVF1BI DI DMVF1BI DMVF1BI DN Pyridine derivative 9 DMVF1BI MI TTOHSBA DMVF1BI MN Vascular endothelial growth factor A (VEGFA) DMVF1BI MT DTT DMVF1BI MA Inhibitor DMVF1BI RN VEGFR-2 inhibitors and the therapeutic applications thereof: a patent review (2012-2016).Expert Opin Ther Pat. 2017 Sep;27(9):987-1004. DMVF1BI RU https://www.ncbi.nlm.nih.gov/pubmed/28621580 DMJNE4V DI DMJNE4V DMJNE4V DN Pyridine-2,4-dicarboxylic acid analog 1 DMJNE4V MI TTWAQBO DMJNE4V MN Lysine-specific demethylase 4E (KDM4E) DMJNE4V MT DTT DMJNE4V MA Inhibitor DMJNE4V RN KDM4 histone demethylase inhibitors for anti-cancer agents: a patent review.Expert Opin Ther Pat. 2015 Feb;25(2):135-44. DMJNE4V RU https://www.ncbi.nlm.nih.gov/pubmed/25468267 DMCNWPI DI DMCNWPI DMCNWPI DN Pyridine-2,4-dicarboxylic acid analog 2 DMCNWPI MI TTWAQBO DMCNWPI MN Lysine-specific demethylase 4E (KDM4E) DMCNWPI MT DTT DMCNWPI MA Inhibitor DMCNWPI RN KDM4 histone demethylase inhibitors for anti-cancer agents: a patent review.Expert Opin Ther Pat. 2015 Feb;25(2):135-44. DMCNWPI RU https://www.ncbi.nlm.nih.gov/pubmed/25468267 DM4XAGS DI DM4XAGS DM4XAGS DN Pyridine-2,4-dicarboxylic acid analog 3 DM4XAGS MI TTWAQBO DM4XAGS MN Lysine-specific demethylase 4E (KDM4E) DM4XAGS MT DTT DM4XAGS MA Inhibitor DM4XAGS RN KDM4 histone demethylase inhibitors for anti-cancer agents: a patent review.Expert Opin Ther Pat. 2015 Feb;25(2):135-44. DM4XAGS RU https://www.ncbi.nlm.nih.gov/pubmed/25468267 DMGPCSR DI DMGPCSR DMGPCSR DN Pyridine-2,4-dicarboxylic acid analog 4 DMGPCSR MI TTWAQBO DMGPCSR MN Lysine-specific demethylase 4E (KDM4E) DMGPCSR MT DTT DMGPCSR MA Inhibitor DMGPCSR RN KDM4 histone demethylase inhibitors for anti-cancer agents: a patent review.Expert Opin Ther Pat. 2015 Feb;25(2):135-44. DMGPCSR RU https://www.ncbi.nlm.nih.gov/pubmed/25468267 DMZSTCQ DI DMZSTCQ DMZSTCQ DN Pyridine-2,4-dicarboxylic acid derivative 1 DMZSTCQ MI TT0RGE9 DMZSTCQ MN Lysine-specific demethylase 4 (KDM4) DMZSTCQ MT DTT DMZSTCQ MA Inhibitor DMZSTCQ RN KDM4 histone demethylase inhibitors for anti-cancer agents: a patent review.Expert Opin Ther Pat. 2015 Feb;25(2):135-44. DMZSTCQ RU https://www.ncbi.nlm.nih.gov/pubmed/25468267 DMGCMF5 DI DMGCMF5 DMGCMF5 DN Pyridine-2,4-dicarboxylic acid derivative 2 DMGCMF5 MI TT0RGE9 DMGCMF5 MN Lysine-specific demethylase 4 (KDM4) DMGCMF5 MT DTT DMGCMF5 MA Inhibitor DMGCMF5 RN KDM4 histone demethylase inhibitors for anti-cancer agents: a patent review.Expert Opin Ther Pat. 2015 Feb;25(2):135-44. DMGCMF5 RU https://www.ncbi.nlm.nih.gov/pubmed/25468267 DMCUP4L DI DMCUP4L DMCUP4L DN Pyridine-2,4-dicarboxylic acid derivative 3 DMCUP4L MI TT0RGE9 DMCUP4L MN Lysine-specific demethylase 4 (KDM4) DMCUP4L MT DTT DMCUP4L MA Inhibitor DMCUP4L RN KDM4 histone demethylase inhibitors for anti-cancer agents: a patent review.Expert Opin Ther Pat. 2015 Feb;25(2):135-44. DMCUP4L RU https://www.ncbi.nlm.nih.gov/pubmed/25468267 DM9KOYX DI DM9KOYX DM9KOYX DN Pyridine-amide derivative 1 DM9KOYX MI TTF8P9I DM9KOYX MN Diacylglycerol acyltransferase 1 (DGAT1) DM9KOYX MT DTT DM9KOYX MA Inhibitor DM9KOYX RN Acyltransferase inhibitors: a patent review (2010-present).Expert Opin Ther Pat. 2015 Feb;25(2):145-58. DM9KOYX RU https://www.ncbi.nlm.nih.gov/pubmed/25470667 DM25M8D DI DM25M8D DM25M8D DN Pyridine-carboximide derivative 1 DM25M8D MI TTF8P9I DM25M8D MN Diacylglycerol acyltransferase 1 (DGAT1) DM25M8D MT DTT DM25M8D MA Inhibitor DM25M8D RN Acyltransferase inhibitors: a patent review (2010-present).Expert Opin Ther Pat. 2015 Feb;25(2):145-58. DM25M8D RU https://www.ncbi.nlm.nih.gov/pubmed/25470667 DMHXWZB DI DMHXWZB DMHXWZB DN Pyridine-carboximide derivative 2 DMHXWZB MI TTF8P9I DMHXWZB MN Diacylglycerol acyltransferase 1 (DGAT1) DMHXWZB MT DTT DMHXWZB MA Inhibitor DMHXWZB RN Acyltransferase inhibitors: a patent review (2010-present).Expert Opin Ther Pat. 2015 Feb;25(2):145-58. DMHXWZB RU https://www.ncbi.nlm.nih.gov/pubmed/25470667 DMKQFTY DI DMKQFTY DMKQFTY DN Pyridino tricyclic compound 1 DMKQFTY MI TTZJYKH DMKQFTY MN Indoleamine 2,3-dioxygenase 1 (IDO1) DMKQFTY MT DTT DMKQFTY MA Inhibitor DMKQFTY RN A patent review of IDO1 inhibitors for cancer.Expert Opin Ther Pat. 2018 Apr;28(4):317-330. DMKQFTY RU https://www.ncbi.nlm.nih.gov/pubmed/29473428 DM3F4KS DI DM3F4KS DM3F4KS DN Pyridinone carboxamide derivative 1 DM3F4KS MI TTCZOF2 DM3F4KS MN Pyruvate dehydrogenase kinase 1 (PDHK1) DM3F4KS MT DTT DM3F4KS MA Inhibitor DM3F4KS RN PDK1 disruptors and modulators: a patent review.Expert Opin Ther Pat. 2015 May;25(5):513-37. DM3F4KS RU https://www.ncbi.nlm.nih.gov/pubmed/25684022 DM2GR5Q DI DM2GR5Q DM2GR5Q DN Pyridinone compound 1 DM2GR5Q MI TTZCRP3 DM2GR5Q MN ERK activator kinase (MEK) DM2GR5Q MT DTT DM2GR5Q MA Inhibitor DM2GR5Q RN MEK inhibitors in oncology: a patent review (2015-Present).Expert Opin Ther Pat. 2017 Aug;27(8):887-906. DM2GR5Q RU https://www.ncbi.nlm.nih.gov/pubmed/28594589 DMK5YJI DI DMK5YJI DMK5YJI DN Pyrido/pyrrolo-fused pyrimidine derivative 1 DMK5YJI MI TTSCIM2 DMK5YJI MN Extracellular lysophospholipase D (E-NPP2) DMK5YJI MT DTT DMK5YJI MA Inhibitor DMK5YJI RN Autotaxin inhibitors: a patent review (2012-2016).Expert Opin Ther Pat. 2017 Jul;27(7):815-829. DMK5YJI RU https://www.ncbi.nlm.nih.gov/pubmed/28447479 DMHKRVL DI DMHKRVL DMHKRVL DN Pyrido[1,2,4]triazolo[4,3-a]pyrazine derivative 1 DMHKRVL MI TTJW4LU DMHKRVL MN Phosphodiesterase 10A (PDE10) DMHKRVL MT DTT DMHKRVL MA Inhibitor DMHKRVL RN Towards selective phosphodiesterase 2A (PDE2A) inhibitors: a patent review (2010 - present).Expert Opin Ther Pat. 2016 Aug;26(8):933-46. DMHKRVL RU https://www.ncbi.nlm.nih.gov/pubmed/27321640 DMHKRVL DI DMHKRVL DMHKRVL DN Pyrido[1,2,4]triazolo[4,3-a]pyrazine derivative 1 DMHKRVL MI TTJGW1Z DMHKRVL MN Phosphodiesterase 2A (PDE2A) DMHKRVL MT DTT DMHKRVL MA Inhibitor DMHKRVL RN Towards selective phosphodiesterase 2A (PDE2A) inhibitors: a patent review (2010 - present).Expert Opin Ther Pat. 2016 Aug;26(8):933-46. DMHKRVL RU https://www.ncbi.nlm.nih.gov/pubmed/27321640 DMUO25Y DI DMUO25Y DMUO25Y DN Pyrido[1,2,4]triazolo[4,3-a]pyrazine derivative 2 DMUO25Y MI TTJW4LU DMUO25Y MN Phosphodiesterase 10A (PDE10) DMUO25Y MT DTT DMUO25Y MA Inhibitor DMUO25Y RN Towards selective phosphodiesterase 2A (PDE2A) inhibitors: a patent review (2010 - present).Expert Opin Ther Pat. 2016 Aug;26(8):933-46. DMUO25Y RU https://www.ncbi.nlm.nih.gov/pubmed/27321640 DMUO25Y DI DMUO25Y DMUO25Y DN Pyrido[1,2,4]triazolo[4,3-a]pyrazine derivative 2 DMUO25Y MI TTJGW1Z DMUO25Y MN Phosphodiesterase 2A (PDE2A) DMUO25Y MT DTT DMUO25Y MA Inhibitor DMUO25Y RN Towards selective phosphodiesterase 2A (PDE2A) inhibitors: a patent review (2010 - present).Expert Opin Ther Pat. 2016 Aug;26(8):933-46. DMUO25Y RU https://www.ncbi.nlm.nih.gov/pubmed/27321640 DMAEYNT DI DMAEYNT DMAEYNT DN Pyrido[1,2,4]triazolo[4,3-a]pyrazine derivative 3 DMAEYNT MI TTJW4LU DMAEYNT MN Phosphodiesterase 10A (PDE10) DMAEYNT MT DTT DMAEYNT MA Inhibitor DMAEYNT RN Towards selective phosphodiesterase 2A (PDE2A) inhibitors: a patent review (2010 - present).Expert Opin Ther Pat. 2016 Aug;26(8):933-46. DMAEYNT RU https://www.ncbi.nlm.nih.gov/pubmed/27321640 DMAEYNT DI DMAEYNT DMAEYNT DN Pyrido[1,2,4]triazolo[4,3-a]pyrazine derivative 3 DMAEYNT MI TTJGW1Z DMAEYNT MN Phosphodiesterase 2A (PDE2A) DMAEYNT MT DTT DMAEYNT MA Inhibitor DMAEYNT RN Towards selective phosphodiesterase 2A (PDE2A) inhibitors: a patent review (2010 - present).Expert Opin Ther Pat. 2016 Aug;26(8):933-46. DMAEYNT RU https://www.ncbi.nlm.nih.gov/pubmed/27321640 DMF0XI3 DI DMF0XI3 DMF0XI3 DN Pyrido[1,2-a]indole-1.-carboxylic acid analog 1 DMF0XI3 MI TTV8CRH DMF0XI3 MN Lysine-specific demethylase 4C (KDM4C) DMF0XI3 MT DTT DMF0XI3 MA Inhibitor DMF0XI3 RN KDM4 histone demethylase inhibitors for anti-cancer agents: a patent review.Expert Opin Ther Pat. 2015 Feb;25(2):135-44. DMF0XI3 RU https://www.ncbi.nlm.nih.gov/pubmed/25468267 DMWMV48 DI DMWMV48 DMWMV48 DN Pyrido[1,2-a]indole-1.-carboxylic acid analog 2 DMWMV48 MI TTV8CRH DMWMV48 MN Lysine-specific demethylase 4C (KDM4C) DMWMV48 MT DTT DMWMV48 MA Inhibitor DMWMV48 RN KDM4 histone demethylase inhibitors for anti-cancer agents: a patent review.Expert Opin Ther Pat. 2015 Feb;25(2):135-44. DMWMV48 RU https://www.ncbi.nlm.nih.gov/pubmed/25468267 DMCLKBY DI DMCLKBY DMCLKBY DN Pyrido[1,2-a]indole-1.-carboxylic acid analog 3 DMCLKBY MI TTV8CRH DMCLKBY MN Lysine-specific demethylase 4C (KDM4C) DMCLKBY MT DTT DMCLKBY MA Inhibitor DMCLKBY RN KDM4 histone demethylase inhibitors for anti-cancer agents: a patent review.Expert Opin Ther Pat. 2015 Feb;25(2):135-44. DMCLKBY RU https://www.ncbi.nlm.nih.gov/pubmed/25468267 DM09FOQ DI DM09FOQ DM09FOQ DN Pyrido[1,2-a]indole-1.-carboxylic acid analog 4 DM09FOQ MI TTV8CRH DM09FOQ MN Lysine-specific demethylase 4C (KDM4C) DM09FOQ MT DTT DM09FOQ MA Inhibitor DM09FOQ RN KDM4 histone demethylase inhibitors for anti-cancer agents: a patent review.Expert Opin Ther Pat. 2015 Feb;25(2):135-44. DM09FOQ RU https://www.ncbi.nlm.nih.gov/pubmed/25468267 DMO3QDW DI DMO3QDW DMO3QDW DN Pyrido[1,2-a]indole-1.-carboxylic acid analog 5 DMO3QDW MI TTV8CRH DMO3QDW MN Lysine-specific demethylase 4C (KDM4C) DMO3QDW MT DTT DMO3QDW MA Inhibitor DMO3QDW RN KDM4 histone demethylase inhibitors for anti-cancer agents: a patent review.Expert Opin Ther Pat. 2015 Feb;25(2):135-44. DMO3QDW RU https://www.ncbi.nlm.nih.gov/pubmed/25468267 DMRQ1ZB DI DMRQ1ZB DMRQ1ZB DN Pyrido[1,2-a]indole-1.-carboxylic acid analog 6 DMRQ1ZB MI TTV8CRH DMRQ1ZB MN Lysine-specific demethylase 4C (KDM4C) DMRQ1ZB MT DTT DMRQ1ZB MA Inhibitor DMRQ1ZB RN KDM4 histone demethylase inhibitors for anti-cancer agents: a patent review.Expert Opin Ther Pat. 2015 Feb;25(2):135-44. DMRQ1ZB RU https://www.ncbi.nlm.nih.gov/pubmed/25468267 DMXY3F0 DI DMXY3F0 DMXY3F0 DN Pyrido[1,2-a]indole-1.-carboxylic acid analog 7 DMXY3F0 MI TTV8CRH DMXY3F0 MN Lysine-specific demethylase 4C (KDM4C) DMXY3F0 MT DTT DMXY3F0 MA Inhibitor DMXY3F0 RN KDM4 histone demethylase inhibitors for anti-cancer agents: a patent review.Expert Opin Ther Pat. 2015 Feb;25(2):135-44. DMXY3F0 RU https://www.ncbi.nlm.nih.gov/pubmed/25468267 DMHZLSO DI DMHZLSO DMHZLSO DN Pyrido[2,3-d]pyrimidine derivative 1 DMHZLSO MI TT6OEDT DMHZLSO MN Cannabinoid receptor 1 (CB1) DMHZLSO MT DTT DMHZLSO MA Antagonist DMHZLSO RN A comprehensive patents review on cannabinoid 1 receptor antagonists as antiobesity agents. Expert Opin Ther Pat. 2015 Oct;25(10):1093-116. DMHZLSO RU https://pubmed.ncbi.nlm.nih.gov/26161824 DMSM53I DI DMSM53I DMSM53I DN Pyrido[2,3-d]pyrimidine derivative 2 DMSM53I MI TT6OEDT DMSM53I MN Cannabinoid receptor 1 (CB1) DMSM53I MT DTT DMSM53I MA Antagonist DMSM53I RN A comprehensive patents review on cannabinoid 1 receptor antagonists as antiobesity agents. Expert Opin Ther Pat. 2015 Oct;25(10):1093-116. DMSM53I RU https://pubmed.ncbi.nlm.nih.gov/26161824 DMM8CL4 DI DMM8CL4 DMM8CL4 DN Pyrido[2,3-d]pyrimidine-2,4-diamine derivative 1 DMM8CL4 MI TTJGW1Z DMM8CL4 MN Phosphodiesterase 2A (PDE2A) DMM8CL4 MT DTT DMM8CL4 MA Inhibitor DMM8CL4 RN Towards selective phosphodiesterase 2A (PDE2A) inhibitors: a patent review (2010 - present).Expert Opin Ther Pat. 2016 Aug;26(8):933-46. DMM8CL4 RU https://www.ncbi.nlm.nih.gov/pubmed/27321640 DMRHAU4 DI DMRHAU4 DMRHAU4 DN Pyrido[3,2-d]pyrimidine derivative 2 DMRHAU4 MI TTTDVOJ DMRHAU4 MN Tropomyosin-related kinase A (TrkA) DMRHAU4 MT DTT DMRHAU4 MA Inhibitor DMRHAU4 RN Tropomyosin receptor kinase inhibitors: an updated patent review for 2010-2016 - Part II.Expert Opin Ther Pat. 2017 Jul;27(7):831-849. DMRHAU4 RU https://www.ncbi.nlm.nih.gov/pubmed/28270021 DM6D1XR DI DM6D1XR DM6D1XR DN Pyrido[3,2-d]pyrimidine derivative 3 DM6D1XR MI TTTDVOJ DM6D1XR MN Tropomyosin-related kinase A (TrkA) DM6D1XR MT DTT DM6D1XR MA Inhibitor DM6D1XR RN Tropomyosin receptor kinase inhibitors: an updated patent review for 2010-2016 - Part II.Expert Opin Ther Pat. 2017 Jul;27(7):831-849. DM6D1XR RU https://www.ncbi.nlm.nih.gov/pubmed/28270021 DMC8935 DI DMC8935 DMC8935 DN Pyrido[3,2-e][1,2,4]triazolo[4,3-a]pyrazine derivative 1 DMC8935 MI TTJW4LU DMC8935 MN Phosphodiesterase 10A (PDE10) DMC8935 MT DTT DMC8935 MA Inhibitor DMC8935 RN Towards selective phosphodiesterase 2A (PDE2A) inhibitors: a patent review (2010 - present).Expert Opin Ther Pat. 2016 Aug;26(8):933-46. DMC8935 RU https://www.ncbi.nlm.nih.gov/pubmed/27321640 DMC8935 DI DMC8935 DMC8935 DN Pyrido[3,2-e][1,2,4]triazolo[4,3-a]pyrazine derivative 1 DMC8935 MI TTJGW1Z DMC8935 MN Phosphodiesterase 2A (PDE2A) DMC8935 MT DTT DMC8935 MA Inhibitor DMC8935 RN Towards selective phosphodiesterase 2A (PDE2A) inhibitors: a patent review (2010 - present).Expert Opin Ther Pat. 2016 Aug;26(8):933-46. DMC8935 RU https://www.ncbi.nlm.nih.gov/pubmed/27321640 DMC8935 DI DMC8935 DMC8935 DN Pyrido[3,2-e][1,2,4]triazolo[4,3-a]pyrazine derivative 1 DMC8935 MI TTQ6VDM DMC8935 MN Voltage-gated potassium channel Kv11.1 (KCNH2) DMC8935 MT DTT DMC8935 MA Inhibitor DMC8935 RN Towards selective phosphodiesterase 2A (PDE2A) inhibitors: a patent review (2010 - present).Expert Opin Ther Pat. 2016 Aug;26(8):933-46. DMC8935 RU https://www.ncbi.nlm.nih.gov/pubmed/27321640 DM4CSBD DI DM4CSBD DM4CSBD DN Pyrido[3,2-e][1,2,4]triazolo[4,3-a]pyrazine derivative 2 DM4CSBD MI TTJW4LU DM4CSBD MN Phosphodiesterase 10A (PDE10) DM4CSBD MT DTT DM4CSBD MA Inhibitor DM4CSBD RN Towards selective phosphodiesterase 2A (PDE2A) inhibitors: a patent review (2010 - present).Expert Opin Ther Pat. 2016 Aug;26(8):933-46. DM4CSBD RU https://www.ncbi.nlm.nih.gov/pubmed/27321640 DM4CSBD DI DM4CSBD DM4CSBD DN Pyrido[3,2-e][1,2,4]triazolo[4,3-a]pyrazine derivative 2 DM4CSBD MI TTJGW1Z DM4CSBD MN Phosphodiesterase 2A (PDE2A) DM4CSBD MT DTT DM4CSBD MA Inhibitor DM4CSBD RN Towards selective phosphodiesterase 2A (PDE2A) inhibitors: a patent review (2010 - present).Expert Opin Ther Pat. 2016 Aug;26(8):933-46. DM4CSBD RU https://www.ncbi.nlm.nih.gov/pubmed/27321640 DM4CSBD DI DM4CSBD DM4CSBD DN Pyrido[3,2-e][1,2,4]triazolo[4,3-a]pyrazine derivative 2 DM4CSBD MI TTQ6VDM DM4CSBD MN Voltage-gated potassium channel Kv11.1 (KCNH2) DM4CSBD MT DTT DM4CSBD MA Inhibitor DM4CSBD RN Towards selective phosphodiesterase 2A (PDE2A) inhibitors: a patent review (2010 - present).Expert Opin Ther Pat. 2016 Aug;26(8):933-46. DM4CSBD RU https://www.ncbi.nlm.nih.gov/pubmed/27321640 DMOTGEK DI DMOTGEK DMOTGEK DN Pyrido[4,3-d]pyrimidin-5(6H)-one derivative 1 DMOTGEK MI TTCZOF2 DMOTGEK MN Pyruvate dehydrogenase kinase 1 (PDHK1) DMOTGEK MT DTT DMOTGEK MA Inhibitor DMOTGEK RN PDK1 disruptors and modulators: a patent review.Expert Opin Ther Pat. 2015 May;25(5):513-37. DMOTGEK RU https://www.ncbi.nlm.nih.gov/pubmed/25684022 DMP6TUQ DI DMP6TUQ DMP6TUQ DN Pyridoindole derivative 1 DMP6TUQ MI TTS7G69 DMP6TUQ MN Fusion protein Bcr-Abl (Bcr-Abl) DMP6TUQ MT DTT DMP6TUQ MA Inhibitor DMP6TUQ RN Bcr-Abl tyrosine kinase inhibitors: a patent review.Expert Opin Ther Pat. 2015 Apr;25(4):397-412. DMP6TUQ RU https://www.ncbi.nlm.nih.gov/pubmed/25656651 DMIXK7Y DI DMIXK7Y DMIXK7Y DN Pyridoindole derivative 2 DMIXK7Y MI TTS7G69 DMIXK7Y MN Fusion protein Bcr-Abl (Bcr-Abl) DMIXK7Y MT DTT DMIXK7Y MA Inhibitor DMIXK7Y RN Bcr-Abl tyrosine kinase inhibitors: a patent review.Expert Opin Ther Pat. 2015 Apr;25(4):397-412. DMIXK7Y RU https://www.ncbi.nlm.nih.gov/pubmed/25656651 DMONCT1 DI DMONCT1 DMONCT1 DN Pyridoindole derivative 3 DMONCT1 MI TTS7G69 DMONCT1 MN Fusion protein Bcr-Abl (Bcr-Abl) DMONCT1 MT DTT DMONCT1 MA Inhibitor DMONCT1 RN Bcr-Abl tyrosine kinase inhibitors: a patent review.Expert Opin Ther Pat. 2015 Apr;25(4):397-412. DMONCT1 RU https://www.ncbi.nlm.nih.gov/pubmed/25656651 DMTZK6V DI DMTZK6V DMTZK6V DN Pyridopyrimidine derivative 1 DMTZK6V MI TTZCRP3 DMTZK6V MN ERK activator kinase (MEK) DMTZK6V MT DTT DMTZK6V MA Inhibitor DMTZK6V RN MEK inhibitors in oncology: a patent review (2015-Present).Expert Opin Ther Pat. 2017 Aug;27(8):887-906. DMTZK6V RU https://www.ncbi.nlm.nih.gov/pubmed/28594589 DMZ6TSD DI DMZ6TSD DMZ6TSD DN Pyridopyrimidinone derivative 1 DMZ6TSD MI TTK0FEA DMZ6TSD MN Leucine-rich repeat kinase 2 (LRRK2) DMZ6TSD MT DTT DMZ6TSD MA Inhibitor DMZ6TSD RN Leucine-rich repeat kinase 2 inhibitors: a patent review (2014-2016).Expert Opin Ther Pat. 2017 Jun;27(6):667-676. DMZ6TSD RU https://www.ncbi.nlm.nih.gov/pubmed/28117607 DMUF63N DI DMUF63N DMUF63N DN Pyridopyrimidinone derivative 2 DMUF63N MI TTK0FEA DMUF63N MN Leucine-rich repeat kinase 2 (LRRK2) DMUF63N MT DTT DMUF63N MA Inhibitor DMUF63N RN Leucine-rich repeat kinase 2 inhibitors: a patent review (2014-2016).Expert Opin Ther Pat. 2017 Jun;27(6):667-676. DMUF63N RU https://www.ncbi.nlm.nih.gov/pubmed/28117607 DMHSDUR DI DMHSDUR DMHSDUR DN Pyridopyrimidinone derivative 3 DMHSDUR MI TTK0FEA DMHSDUR MN Leucine-rich repeat kinase 2 (LRRK2) DMHSDUR MT DTT DMHSDUR MA Inhibitor DMHSDUR RN Leucine-rich repeat kinase 2 inhibitors: a patent review (2014-2016).Expert Opin Ther Pat. 2017 Jun;27(6):667-676. DMHSDUR RU https://www.ncbi.nlm.nih.gov/pubmed/28117607 DM71UYI DI DM71UYI DM71UYI DN Pyridotriazolopyrimidine derivative 1 DM71UYI MI TT6OEDT DM71UYI MN Cannabinoid receptor 1 (CB1) DM71UYI MT DTT DM71UYI MA Antagonist DM71UYI RN A comprehensive patents review on cannabinoid 1 receptor antagonists as antiobesity agents. Expert Opin Ther Pat. 2015 Oct;25(10):1093-116. DM71UYI RU https://pubmed.ncbi.nlm.nih.gov/26161824 DM0VOY9 DI DM0VOY9 DM0VOY9 DN Pyridotriazolopyrimidine derivative 2 DM0VOY9 MI TT6OEDT DM0VOY9 MN Cannabinoid receptor 1 (CB1) DM0VOY9 MT DTT DM0VOY9 MA Antagonist DM0VOY9 RN A comprehensive patents review on cannabinoid 1 receptor antagonists as antiobesity agents. Expert Opin Ther Pat. 2015 Oct;25(10):1093-116. DM0VOY9 RU https://pubmed.ncbi.nlm.nih.gov/26161824 DMYVCTD DI DMYVCTD DMYVCTD DN Pyridotriazolopyrimidine derivative 3 DMYVCTD MI TT6OEDT DMYVCTD MN Cannabinoid receptor 1 (CB1) DMYVCTD MT DTT DMYVCTD MA Antagonist DMYVCTD RN A comprehensive patents review on cannabinoid 1 receptor antagonists as antiobesity agents. Expert Opin Ther Pat. 2015 Oct;25(10):1093-116. DMYVCTD RU https://pubmed.ncbi.nlm.nih.gov/26161824 DMUTE5S DI DMUTE5S DMUTE5S DN Pyridyl compound 1 DMUTE5S MI TT3Z6Y9 DMUTE5S MN Cysteines of Keap1 (KEAP1 Cysteines) DMUTE5S MT DTT DMUTE5S MA Modulator DMUTE5S RN Recent progress in the development of small molecule Nrf2 modulators: a patent review (2012-2016).Expert Opin Ther Pat. 2017 Jul;27(7):763-785. DMUTE5S RU https://www.ncbi.nlm.nih.gov/pubmed/28454500 DMUTE5S DI DMUTE5S DMUTE5S DN Pyridyl compound 1 DMUTE5S MI TTA6ZN2 DMUTE5S MN Nuclear factor erythroid 2-related factor 2 (Nrf2) DMUTE5S MT DTT DMUTE5S MA Activator DMUTE5S RN Recent progress in the development of small molecule Nrf2 modulators: a patent review (2012-2016).Expert Opin Ther Pat. 2017 Jul;27(7):763-785. DMUTE5S RU https://www.ncbi.nlm.nih.gov/pubmed/28454500 DMD6GNO DI DMD6GNO DMD6GNO DN Pyrimidine benzenesulfonamide derivative 1 DMD6GNO MI TTIY56R DMD6GNO MN Kynurenine 3-hydroxylase (KMO) DMD6GNO MT DTT DMD6GNO MA Inhibitor DMD6GNO RN Inhibitors of the kynurenine pathway as neurotherapeutics: a patent review (2012-2015).Expert Opin Ther Pat. 2016 Jul;26(7):815-32. DMD6GNO RU https://www.ncbi.nlm.nih.gov/pubmed/27172114 DMVQ4NS DI DMVQ4NS DMVQ4NS DN Pyrimidine benzenesulfonamide derivative 2 DMVQ4NS MI TTIY56R DMVQ4NS MN Kynurenine 3-hydroxylase (KMO) DMVQ4NS MT DTT DMVQ4NS MA Inhibitor DMVQ4NS RN Inhibitors of the kynurenine pathway as neurotherapeutics: a patent review (2012-2015).Expert Opin Ther Pat. 2016 Jul;26(7):815-32. DMVQ4NS RU https://www.ncbi.nlm.nih.gov/pubmed/27172114 DMJ71Q0 DI DMJ71Q0 DMJ71Q0 DN Pyrimidine benzenesulfonamide derivative 3 DMJ71Q0 MI TTIY56R DMJ71Q0 MN Kynurenine 3-hydroxylase (KMO) DMJ71Q0 MT DTT DMJ71Q0 MA Inhibitor DMJ71Q0 RN Inhibitors of the kynurenine pathway as neurotherapeutics: a patent review (2012-2015).Expert Opin Ther Pat. 2016 Jul;26(7):815-32. DMJ71Q0 RU https://www.ncbi.nlm.nih.gov/pubmed/27172114 DMN9VQM DI DMN9VQM DMN9VQM DN Pyrimidine derivative 1 DMN9VQM MI TTAXZ0K DMN9VQM MN Voltage-gated sodium channel alpha Nav1.3 (SCN3A) DMN9VQM MT DTT DMN9VQM MA Blocker DMN9VQM RN Sodium channel blockers: a patent review (2010 - 2014).Expert Opin Ther Pat. 2015 Mar;25(3):279-90. DMN9VQM RU https://www.ncbi.nlm.nih.gov/pubmed/25539043 DMN9VQM DI DMN9VQM DMN9VQM DN Pyrimidine derivative 1 DMN9VQM MI TT4G2JS DMN9VQM MN Voltage-gated sodium channel alpha Nav1.7 (SCN9A) DMN9VQM MT DTT DMN9VQM MA Blocker DMN9VQM RN Sodium channel blockers: a patent review (2010 - 2014).Expert Opin Ther Pat. 2015 Mar;25(3):279-90. DMN9VQM RU https://www.ncbi.nlm.nih.gov/pubmed/25539043 DMBEZUY DI DMBEZUY DMBEZUY DN Pyrimidine derivative 10 DMBEZUY MI TTOHSBA DMBEZUY MN Vascular endothelial growth factor A (VEGFA) DMBEZUY MT DTT DMBEZUY MA Inhibitor DMBEZUY RN VEGFR-2 inhibitors and the therapeutic applications thereof: a patent review (2012-2016).Expert Opin Ther Pat. 2017 Sep;27(9):987-1004. DMBEZUY RU https://www.ncbi.nlm.nih.gov/pubmed/28621580 DMJ4QD5 DI DMJ4QD5 DMJ4QD5 DN Pyrimidine derivative 11 DMJ4QD5 MI TTOHSBA DMJ4QD5 MN Vascular endothelial growth factor A (VEGFA) DMJ4QD5 MT DTT DMJ4QD5 MA Inhibitor DMJ4QD5 RN VEGFR-2 inhibitors and the therapeutic applications thereof: a patent review (2012-2016).Expert Opin Ther Pat. 2017 Sep;27(9):987-1004. DMJ4QD5 RU https://www.ncbi.nlm.nih.gov/pubmed/28621580 DMMBFQH DI DMMBFQH DMMBFQH DN Pyrimidine derivative 12 DMMBFQH MI TTUTJGQ DMMBFQH MN Vascular endothelial growth factor receptor 2 (KDR) DMMBFQH MT DTT DMMBFQH MA Inhibitor DMMBFQH RN VEGFR-2 inhibitors and the therapeutic applications thereof: a patent review (2012-2016).Expert Opin Ther Pat. 2017 Sep;27(9):987-1004. DMMBFQH RU https://www.ncbi.nlm.nih.gov/pubmed/28621580 DMASGR1 DI DMASGR1 DMASGR1 DN Pyrimidine derivative 13 DMASGR1 MI TTUTJGQ DMASGR1 MN Vascular endothelial growth factor receptor 2 (KDR) DMASGR1 MT DTT DMASGR1 MA Inhibitor DMASGR1 RN VEGFR-2 inhibitors and the therapeutic applications thereof: a patent review (2012-2016).Expert Opin Ther Pat. 2017 Sep;27(9):987-1004. DMASGR1 RU https://www.ncbi.nlm.nih.gov/pubmed/28621580 DM7B2XG DI DM7B2XG DM7B2XG DN Pyrimidine derivative 14 DM7B2XG MI TTUTJGQ DM7B2XG MN Vascular endothelial growth factor receptor 2 (KDR) DM7B2XG MT DTT DM7B2XG MA Inhibitor DM7B2XG RN VEGFR-2 inhibitors and the therapeutic applications thereof: a patent review (2012-2016).Expert Opin Ther Pat. 2017 Sep;27(9):987-1004. DM7B2XG RU https://www.ncbi.nlm.nih.gov/pubmed/28621580 DMV2Y84 DI DMV2Y84 DMV2Y84 DN Pyrimidine derivative 15 DMV2Y84 MI TTDCBX5 DMV2Y84 MN Vascular endothelial growth factor receptor 3 (FLT-4) DMV2Y84 MT DTT DMV2Y84 MA Inhibitor DMV2Y84 RN VEGFR-2 inhibitors and the therapeutic applications thereof: a patent review (2012-2016).Expert Opin Ther Pat. 2017 Sep;27(9):987-1004. DMV2Y84 RU https://www.ncbi.nlm.nih.gov/pubmed/28621580 DM3GYPD DI DM3GYPD DM3GYPD DN Pyrimidine derivative 16 DM3GYPD MI TTNR0UQ DM3GYPD MN Lysine-specific histone demethylase 1 (LSD) DM3GYPD MT DTT DM3GYPD MA Inhibitor DM3GYPD RN LSD1 inhibitors: a patent review (2010-2015).Expert Opin Ther Pat. 2016 May;26(5):565-80. DM3GYPD RU https://www.ncbi.nlm.nih.gov/pubmed/27019002 DM7YA9Z DI DM7YA9Z DM7YA9Z DN Pyrimidine derivative 17 DM7YA9Z MI TTNR0UQ DM7YA9Z MN Lysine-specific histone demethylase 1 (LSD) DM7YA9Z MT DTT DM7YA9Z MA Inhibitor DM7YA9Z RN LSD1 inhibitors: a patent review (2010-2015).Expert Opin Ther Pat. 2016 May;26(5):565-80. DM7YA9Z RU https://www.ncbi.nlm.nih.gov/pubmed/27019002 DMIZTKS DI DMIZTKS DMIZTKS DN Pyrimidine derivative 18 DMIZTKS MI TTNR0UQ DMIZTKS MN Lysine-specific histone demethylase 1 (LSD) DMIZTKS MT DTT DMIZTKS MA Inhibitor DMIZTKS RN LSD1 inhibitors: a patent review (2010-2015).Expert Opin Ther Pat. 2016 May;26(5):565-80. DMIZTKS RU https://www.ncbi.nlm.nih.gov/pubmed/27019002 DMLPO0K DI DMLPO0K DMLPO0K DN Pyrimidine derivative 19 DMLPO0K MI TT8J1S3 DMLPO0K MN Smoothened homolog (SMO) DMLPO0K MT DTT DMLPO0K MA Inhibitor DMLPO0K RN Hedgehog inhibitors: a patent review (2013 - present).Expert Opin Ther Pat. 2015 May;25(5):549-65. DMLPO0K RU https://www.ncbi.nlm.nih.gov/pubmed/25726713 DMS8OR3 DI DMS8OR3 DMS8OR3 DN Pyrimidine derivative 2 DMS8OR3 MI TTYLQ8V DMS8OR3 MN Prostaglandin E synthase (PTGES) DMS8OR3 MT DTT DMS8OR3 MA Inhibitor DMS8OR3 RN Microsomal prostaglandin E2 synthase-1 inhibitors: a patent review.Expert Opin Ther Pat. 2017 Sep;27(9):1047-1059. DMS8OR3 RU https://www.ncbi.nlm.nih.gov/pubmed/28627961 DMQUEDK DI DMQUEDK DMQUEDK DN Pyrimidine derivative 20 DMQUEDK MI TT8J1S3 DMQUEDK MN Smoothened homolog (SMO) DMQUEDK MT DTT DMQUEDK MA Inhibitor DMQUEDK RN Hedgehog inhibitors: a patent review (2013 - present).Expert Opin Ther Pat. 2015 May;25(5):549-65. DMQUEDK RU https://www.ncbi.nlm.nih.gov/pubmed/25726713 DMELA2F DI DMELA2F DMELA2F DN Pyrimidine derivative 21 DMELA2F MI TT8J1S3 DMELA2F MN Smoothened homolog (SMO) DMELA2F MT DTT DMELA2F MA Inhibitor DMELA2F RN Hedgehog inhibitors: a patent review (2013 - present).Expert Opin Ther Pat. 2015 May;25(5):549-65. DMELA2F RU https://www.ncbi.nlm.nih.gov/pubmed/25726713 DMN64AK DI DMN64AK DMN64AK DN Pyrimidine derivative 22 DMN64AK MI TT8J1S3 DMN64AK MN Smoothened homolog (SMO) DMN64AK MT DTT DMN64AK MA Inhibitor DMN64AK RN Hedgehog inhibitors: a patent review (2013 - present).Expert Opin Ther Pat. 2015 May;25(5):549-65. DMN64AK RU https://www.ncbi.nlm.nih.gov/pubmed/25726713 DM5MLQU DI DM5MLQU DM5MLQU DN Pyrimidine derivative 23 DM5MLQU MI TTJQOD7 DM5MLQU MN 5-HT 2A receptor (HTR2A) DM5MLQU MT DTT DM5MLQU MA Antagonist DM5MLQU RN Novel serotonin receptor 2 (5-HT2R) agonists and antagonists: a patent review (2004-2014).Expert Opin Ther Pat. 2016;26(1):89-106. DM5MLQU RU https://www.ncbi.nlm.nih.gov/pubmed/26609882 DM5MLQU DI DM5MLQU DM5MLQU DN Pyrimidine derivative 23 DM5MLQU MI TT0K1SC DM5MLQU MN 5-HT 2B receptor (HTR2B) DM5MLQU MT DTT DM5MLQU MA Antagonist DM5MLQU RN Novel serotonin receptor 2 (5-HT2R) agonists and antagonists: a patent review (2004-2014).Expert Opin Ther Pat. 2016;26(1):89-106. DM5MLQU RU https://www.ncbi.nlm.nih.gov/pubmed/26609882 DM5MLQU DI DM5MLQU DM5MLQU DN Pyrimidine derivative 23 DM5MLQU MI TTWJBZ5 DM5MLQU MN 5-HT 2C receptor (HTR2C) DM5MLQU MT DTT DM5MLQU MA Antagonist DM5MLQU RN Novel serotonin receptor 2 (5-HT2R) agonists and antagonists: a patent review (2004-2014).Expert Opin Ther Pat. 2016;26(1):89-106. DM5MLQU RU https://www.ncbi.nlm.nih.gov/pubmed/26609882 DMOQ726 DI DMOQ726 DMOQ726 DN Pyrimidine derivative 24 DMOQ726 MI TTJQOD7 DMOQ726 MN 5-HT 2A receptor (HTR2A) DMOQ726 MT DTT DMOQ726 MA Antagonist DMOQ726 RN Novel serotonin receptor 2 (5-HT2R) agonists and antagonists: a patent review (2004-2014).Expert Opin Ther Pat. 2016;26(1):89-106. DMOQ726 RU https://www.ncbi.nlm.nih.gov/pubmed/26609882 DMOQ726 DI DMOQ726 DMOQ726 DN Pyrimidine derivative 24 DMOQ726 MI TT0K1SC DMOQ726 MN 5-HT 2B receptor (HTR2B) DMOQ726 MT DTT DMOQ726 MA Antagonist DMOQ726 RN Novel serotonin receptor 2 (5-HT2R) agonists and antagonists: a patent review (2004-2014).Expert Opin Ther Pat. 2016;26(1):89-106. DMOQ726 RU https://www.ncbi.nlm.nih.gov/pubmed/26609882 DMOQ726 DI DMOQ726 DMOQ726 DN Pyrimidine derivative 24 DMOQ726 MI TTWJBZ5 DMOQ726 MN 5-HT 2C receptor (HTR2C) DMOQ726 MT DTT DMOQ726 MA Antagonist DMOQ726 RN Novel serotonin receptor 2 (5-HT2R) agonists and antagonists: a patent review (2004-2014).Expert Opin Ther Pat. 2016;26(1):89-106. DMOQ726 RU https://www.ncbi.nlm.nih.gov/pubmed/26609882 DM51MFS DI DM51MFS DM51MFS DN Pyrimidine derivative 25 DM51MFS MI TTJQOD7 DM51MFS MN 5-HT 2A receptor (HTR2A) DM51MFS MT DTT DM51MFS MA Antagonist DM51MFS RN Novel serotonin receptor 2 (5-HT2R) agonists and antagonists: a patent review (2004-2014).Expert Opin Ther Pat. 2016;26(1):89-106. DM51MFS RU https://www.ncbi.nlm.nih.gov/pubmed/26609882 DM51MFS DI DM51MFS DM51MFS DN Pyrimidine derivative 25 DM51MFS MI TT0K1SC DM51MFS MN 5-HT 2B receptor (HTR2B) DM51MFS MT DTT DM51MFS MA Antagonist DM51MFS RN Novel serotonin receptor 2 (5-HT2R) agonists and antagonists: a patent review (2004-2014).Expert Opin Ther Pat. 2016;26(1):89-106. DM51MFS RU https://www.ncbi.nlm.nih.gov/pubmed/26609882 DM51MFS DI DM51MFS DM51MFS DN Pyrimidine derivative 25 DM51MFS MI TTWJBZ5 DM51MFS MN 5-HT 2C receptor (HTR2C) DM51MFS MT DTT DM51MFS MA Antagonist DM51MFS RN Novel serotonin receptor 2 (5-HT2R) agonists and antagonists: a patent review (2004-2014).Expert Opin Ther Pat. 2016;26(1):89-106. DM51MFS RU https://www.ncbi.nlm.nih.gov/pubmed/26609882 DM90WKN DI DM90WKN DM90WKN DN Pyrimidine derivative 26 DM90WKN MI TTJQOD7 DM90WKN MN 5-HT 2A receptor (HTR2A) DM90WKN MT DTT DM90WKN MA Antagonist DM90WKN RN Novel serotonin receptor 2 (5-HT2R) agonists and antagonists: a patent review (2004-2014).Expert Opin Ther Pat. 2016;26(1):89-106. DM90WKN RU https://www.ncbi.nlm.nih.gov/pubmed/26609882 DM90WKN DI DM90WKN DM90WKN DN Pyrimidine derivative 26 DM90WKN MI TT0K1SC DM90WKN MN 5-HT 2B receptor (HTR2B) DM90WKN MT DTT DM90WKN MA Antagonist DM90WKN RN Novel serotonin receptor 2 (5-HT2R) agonists and antagonists: a patent review (2004-2014).Expert Opin Ther Pat. 2016;26(1):89-106. DM90WKN RU https://www.ncbi.nlm.nih.gov/pubmed/26609882 DM90WKN DI DM90WKN DM90WKN DN Pyrimidine derivative 26 DM90WKN MI TTWJBZ5 DM90WKN MN 5-HT 2C receptor (HTR2C) DM90WKN MT DTT DM90WKN MA Antagonist DM90WKN RN Novel serotonin receptor 2 (5-HT2R) agonists and antagonists: a patent review (2004-2014).Expert Opin Ther Pat. 2016;26(1):89-106. DM90WKN RU https://www.ncbi.nlm.nih.gov/pubmed/26609882 DMIQSDW DI DMIQSDW DMIQSDW DN Pyrimidine derivative 27 DMIQSDW MI TTJQOD7 DMIQSDW MN 5-HT 2A receptor (HTR2A) DMIQSDW MT DTT DMIQSDW MA Antagonist DMIQSDW RN Novel serotonin receptor 2 (5-HT2R) agonists and antagonists: a patent review (2004-2014).Expert Opin Ther Pat. 2016;26(1):89-106. DMIQSDW RU https://www.ncbi.nlm.nih.gov/pubmed/26609882 DMIQSDW DI DMIQSDW DMIQSDW DN Pyrimidine derivative 27 DMIQSDW MI TT0K1SC DMIQSDW MN 5-HT 2B receptor (HTR2B) DMIQSDW MT DTT DMIQSDW MA Antagonist DMIQSDW RN Novel serotonin receptor 2 (5-HT2R) agonists and antagonists: a patent review (2004-2014).Expert Opin Ther Pat. 2016;26(1):89-106. DMIQSDW RU https://www.ncbi.nlm.nih.gov/pubmed/26609882 DMIQSDW DI DMIQSDW DMIQSDW DN Pyrimidine derivative 27 DMIQSDW MI TTWJBZ5 DMIQSDW MN 5-HT 2C receptor (HTR2C) DMIQSDW MT DTT DMIQSDW MA Antagonist DMIQSDW RN Novel serotonin receptor 2 (5-HT2R) agonists and antagonists: a patent review (2004-2014).Expert Opin Ther Pat. 2016;26(1):89-106. DMIQSDW RU https://www.ncbi.nlm.nih.gov/pubmed/26609882 DM1D2AS DI DM1D2AS DM1D2AS DN Pyrimidine derivative 28 DM1D2AS MI TTJQOD7 DM1D2AS MN 5-HT 2A receptor (HTR2A) DM1D2AS MT DTT DM1D2AS MA Antagonist DM1D2AS RN Novel serotonin receptor 2 (5-HT2R) agonists and antagonists: a patent review (2004-2014).Expert Opin Ther Pat. 2016;26(1):89-106. DM1D2AS RU https://www.ncbi.nlm.nih.gov/pubmed/26609882 DM1D2AS DI DM1D2AS DM1D2AS DN Pyrimidine derivative 28 DM1D2AS MI TT0K1SC DM1D2AS MN 5-HT 2B receptor (HTR2B) DM1D2AS MT DTT DM1D2AS MA Antagonist DM1D2AS RN Novel serotonin receptor 2 (5-HT2R) agonists and antagonists: a patent review (2004-2014).Expert Opin Ther Pat. 2016;26(1):89-106. DM1D2AS RU https://www.ncbi.nlm.nih.gov/pubmed/26609882 DM1D2AS DI DM1D2AS DM1D2AS DN Pyrimidine derivative 28 DM1D2AS MI TTWJBZ5 DM1D2AS MN 5-HT 2C receptor (HTR2C) DM1D2AS MT DTT DM1D2AS MA Antagonist DM1D2AS RN Novel serotonin receptor 2 (5-HT2R) agonists and antagonists: a patent review (2004-2014).Expert Opin Ther Pat. 2016;26(1):89-106. DM1D2AS RU https://www.ncbi.nlm.nih.gov/pubmed/26609882 DMVOYJ8 DI DMVOYJ8 DMVOYJ8 DN Pyrimidine derivative 29 DMVOYJ8 MI TTJQOD7 DMVOYJ8 MN 5-HT 2A receptor (HTR2A) DMVOYJ8 MT DTT DMVOYJ8 MA Antagonist DMVOYJ8 RN Novel serotonin receptor 2 (5-HT2R) agonists and antagonists: a patent review (2004-2014).Expert Opin Ther Pat. 2016;26(1):89-106. DMVOYJ8 RU https://www.ncbi.nlm.nih.gov/pubmed/26609882 DMVOYJ8 DI DMVOYJ8 DMVOYJ8 DN Pyrimidine derivative 29 DMVOYJ8 MI TT0K1SC DMVOYJ8 MN 5-HT 2B receptor (HTR2B) DMVOYJ8 MT DTT DMVOYJ8 MA Antagonist DMVOYJ8 RN Novel serotonin receptor 2 (5-HT2R) agonists and antagonists: a patent review (2004-2014).Expert Opin Ther Pat. 2016;26(1):89-106. DMVOYJ8 RU https://www.ncbi.nlm.nih.gov/pubmed/26609882 DMVOYJ8 DI DMVOYJ8 DMVOYJ8 DN Pyrimidine derivative 29 DMVOYJ8 MI TTWJBZ5 DMVOYJ8 MN 5-HT 2C receptor (HTR2C) DMVOYJ8 MT DTT DMVOYJ8 MA Antagonist DMVOYJ8 RN Novel serotonin receptor 2 (5-HT2R) agonists and antagonists: a patent review (2004-2014).Expert Opin Ther Pat. 2016;26(1):89-106. DMVOYJ8 RU https://www.ncbi.nlm.nih.gov/pubmed/26609882 DMC3E8M DI DMC3E8M DMC3E8M DN Pyrimidine derivative 3 DMC3E8M MI TTCZOF2 DMC3E8M MN Pyruvate dehydrogenase kinase 1 (PDHK1) DMC3E8M MT DTT DMC3E8M MA Inhibitor DMC3E8M RN PDK1 disruptors and modulators: a patent review.Expert Opin Ther Pat. 2015 May;25(5):513-37. DMC3E8M RU https://www.ncbi.nlm.nih.gov/pubmed/25684022 DMTQBUD DI DMTQBUD DMTQBUD DN Pyrimidine derivative 30 DMTQBUD MI TTDIGC1 DMTQBUD MN Dipeptidyl peptidase 4 (DPP-4) DMTQBUD MT DTT DMTQBUD MA Inhibitor DMTQBUD RN DPP-4 inhibitors: a patent review (2012 - 2014).Expert Opin Ther Pat. 2015 Feb;25(2):209-36. DMTQBUD RU https://www.ncbi.nlm.nih.gov/pubmed/25482888 DMOJTLU DI DMOJTLU DMOJTLU DN Pyrimidine derivative 31 DMOJTLU MI TTDIGC1 DMOJTLU MN Dipeptidyl peptidase 4 (DPP-4) DMOJTLU MT DTT DMOJTLU MA Inhibitor DMOJTLU RN DPP-4 inhibitors: a patent review (2012 - 2014).Expert Opin Ther Pat. 2015 Feb;25(2):209-36. DMOJTLU RU https://www.ncbi.nlm.nih.gov/pubmed/25482888 DMCUQFG DI DMCUQFG DMCUQFG DN Pyrimidine derivative 32 DMCUQFG MI TTDIGC1 DMCUQFG MN Dipeptidyl peptidase 4 (DPP-4) DMCUQFG MT DTT DMCUQFG MA Inhibitor DMCUQFG RN DPP-4 inhibitors: a patent review (2012 - 2014).Expert Opin Ther Pat. 2015 Feb;25(2):209-36. DMCUQFG RU https://www.ncbi.nlm.nih.gov/pubmed/25482888 DMWL5V0 DI DMWL5V0 DMWL5V0 DN Pyrimidine derivative 33 DMWL5V0 MI TTDIGC1 DMWL5V0 MN Dipeptidyl peptidase 4 (DPP-4) DMWL5V0 MT DTT DMWL5V0 MA Inhibitor DMWL5V0 RN DPP-4 inhibitors: a patent review (2012 - 2014).Expert Opin Ther Pat. 2015 Feb;25(2):209-36. DMWL5V0 RU https://www.ncbi.nlm.nih.gov/pubmed/25482888 DM4192V DI DM4192V DM4192V DN Pyrimidine derivative 34 DM4192V MI TTPLTSQ DM4192V MN Neutrophil elastase (NE) DM4192V MT DTT DM4192V MA Inhibitor DM4192V RN Neutrophil elastase inhibitors: a patent review and potential applications for inflammatory lung diseases (2010 - 2014).Expert Opin Ther Pat. 2015;25(10):1145-58. DM4192V RU https://www.ncbi.nlm.nih.gov/pubmed/26118988 DM8K6IS DI DM8K6IS DM8K6IS DN Pyrimidine derivative 4 DM8K6IS MI TTUTJGQ DM8K6IS MN Vascular endothelial growth factor receptor 2 (KDR) DM8K6IS MT DTT DM8K6IS MA Inhibitor DM8K6IS RN VEGFR-2 inhibitors and the therapeutic applications thereof: a patent review (2012-2016).Expert Opin Ther Pat. 2017 Sep;27(9):987-1004. DM8K6IS RU https://www.ncbi.nlm.nih.gov/pubmed/28621580 DMNET19 DI DMNET19 DMNET19 DN Pyrimidine derivative 5 DMNET19 MI TTOHSBA DMNET19 MN Vascular endothelial growth factor A (VEGFA) DMNET19 MT DTT DMNET19 MA Inhibitor DMNET19 RN VEGFR-2 inhibitors and the therapeutic applications thereof: a patent review (2012-2016).Expert Opin Ther Pat. 2017 Sep;27(9):987-1004. DMNET19 RU https://www.ncbi.nlm.nih.gov/pubmed/28621580 DMBAHYO DI DMBAHYO DMBAHYO DN Pyrimidine derivative 6 DMBAHYO MI TTOHSBA DMBAHYO MN Vascular endothelial growth factor A (VEGFA) DMBAHYO MT DTT DMBAHYO MA Inhibitor DMBAHYO RN VEGFR-2 inhibitors and the therapeutic applications thereof: a patent review (2012-2016).Expert Opin Ther Pat. 2017 Sep;27(9):987-1004. DMBAHYO RU https://www.ncbi.nlm.nih.gov/pubmed/28621580 DMF6DUT DI DMF6DUT DMF6DUT DN Pyrimidine derivative 7 DMF6DUT MI TTOHSBA DMF6DUT MN Vascular endothelial growth factor A (VEGFA) DMF6DUT MT DTT DMF6DUT MA Inhibitor DMF6DUT RN VEGFR-2 inhibitors and the therapeutic applications thereof: a patent review (2012-2016).Expert Opin Ther Pat. 2017 Sep;27(9):987-1004. DMF6DUT RU https://www.ncbi.nlm.nih.gov/pubmed/28621580 DMVW25O DI DMVW25O DMVW25O DN Pyrimidine derivative 8 DMVW25O MI TTOHSBA DMVW25O MN Vascular endothelial growth factor A (VEGFA) DMVW25O MT DTT DMVW25O MA Inhibitor DMVW25O RN VEGFR-2 inhibitors and the therapeutic applications thereof: a patent review (2012-2016).Expert Opin Ther Pat. 2017 Sep;27(9):987-1004. DMVW25O RU https://www.ncbi.nlm.nih.gov/pubmed/28621580 DMV6U9Y DI DMV6U9Y DMV6U9Y DN Pyrimidine derivative 9 DMV6U9Y MI TTOHSBA DMV6U9Y MN Vascular endothelial growth factor A (VEGFA) DMV6U9Y MT DTT DMV6U9Y MA Inhibitor DMV6U9Y RN VEGFR-2 inhibitors and the therapeutic applications thereof: a patent review (2012-2016).Expert Opin Ther Pat. 2017 Sep;27(9):987-1004. DMV6U9Y RU https://www.ncbi.nlm.nih.gov/pubmed/28621580 DMT6O1N DI DMT6O1N DMT6O1N DN Pyrimidine-4(3H)-one derivative 1 DMT6O1N MI TTJOW1I DMT6O1N MN Mannoside acetylglucosaminyltransferase 2 (MGAT2) DMT6O1N MT DTT DMT6O1N MA Inhibitor DMT6O1N RN Acyltransferase inhibitors: a patent review (2010-present).Expert Opin Ther Pat. 2015 Feb;25(2):145-58. DMT6O1N RU https://www.ncbi.nlm.nih.gov/pubmed/25470667 DML4OYQ DI DML4OYQ DML4OYQ DN Pyrimidinedione derivative 1 DML4OYQ MI TTDIGC1 DML4OYQ MN Dipeptidyl peptidase 4 (DPP-4) DML4OYQ MT DTT DML4OYQ MA Inhibitor DML4OYQ RN DPP-4 inhibitors: a patent review (2012 - 2014).Expert Opin Ther Pat. 2015 Feb;25(2):209-36. DML4OYQ RU https://www.ncbi.nlm.nih.gov/pubmed/25482888 DM1I7Z6 DI DM1I7Z6 DM1I7Z6 DN Pyrimidinone derivative 1 DM1I7Z6 MI TTCZOF2 DM1I7Z6 MN Pyruvate dehydrogenase kinase 1 (PDHK1) DM1I7Z6 MT DTT DM1I7Z6 MA Inhibitor DM1I7Z6 RN PDK1 disruptors and modulators: a patent review.Expert Opin Ther Pat. 2015 May;25(5):513-37. DM1I7Z6 RU https://www.ncbi.nlm.nih.gov/pubmed/25684022 DMDQNKW DI DMDQNKW DMDQNKW DN Pyrimidinone derivative 4 DMDQNKW MI TTPLTSQ DMDQNKW MN Neutrophil elastase (NE) DMDQNKW MT DTT DMDQNKW MA Inhibitor DMDQNKW RN Neutrophil elastase inhibitors: a patent review and potential applications for inflammatory lung diseases (2010 - 2014).Expert Opin Ther Pat. 2015;25(10):1145-58. DMDQNKW RU https://www.ncbi.nlm.nih.gov/pubmed/26118988 DMLFY57 DI DMLFY57 DMLFY57 DN Pyrimidinone derivative 5 DMLFY57 MI TTSCIM2 DMLFY57 MN Extracellular lysophospholipase D (E-NPP2) DMLFY57 MT DTT DMLFY57 MA Inhibitor DMLFY57 RN Autotaxin inhibitors: a patent review (2012-2016).Expert Opin Ther Pat. 2017 Jul;27(7):815-829. DMLFY57 RU https://www.ncbi.nlm.nih.gov/pubmed/28447479 DMYKHQ8 DI DMYKHQ8 DMYKHQ8 DN Pyrimidinyl compound 1 DMYKHQ8 MI TTH5TC2 DMYKHQ8 MN NF-kappa-B-activating kinase (TBK1) DMYKHQ8 MT DTT DMYKHQ8 MA Inhibitor DMYKHQ8 RN TBK1 inhibitors: a review of patent literature (2011 - 2014).Expert Opin Ther Pat. 2015;25(12):1385-96. DMYKHQ8 RU https://www.ncbi.nlm.nih.gov/pubmed/26293650 DM9TW5O DI DM9TW5O DM9TW5O DN Pyrimidinyl compound 2 DM9TW5O MI TTH5TC2 DM9TW5O MN NF-kappa-B-activating kinase (TBK1) DM9TW5O MT DTT DM9TW5O MA Inhibitor DM9TW5O RN TBK1 inhibitors: a review of patent literature (2011 - 2014).Expert Opin Ther Pat. 2015;25(12):1385-96. DM9TW5O RU https://www.ncbi.nlm.nih.gov/pubmed/26293650 DMOE2FZ DI DMOE2FZ DMOE2FZ DN Pyrimidinyl compound 3 DMOE2FZ MI TTH5TC2 DMOE2FZ MN NF-kappa-B-activating kinase (TBK1) DMOE2FZ MT DTT DMOE2FZ MA Inhibitor DMOE2FZ RN TBK1 inhibitors: a review of patent literature (2011 - 2014).Expert Opin Ther Pat. 2015;25(12):1385-96. DMOE2FZ RU https://www.ncbi.nlm.nih.gov/pubmed/26293650 DM53O9Y DI DM53O9Y DM53O9Y DN Pyrimidinyl compound 4 DM53O9Y MI TTH5TC2 DM53O9Y MN NF-kappa-B-activating kinase (TBK1) DM53O9Y MT DTT DM53O9Y MA Inhibitor DM53O9Y RN TBK1 inhibitors: a review of patent literature (2011 - 2014).Expert Opin Ther Pat. 2015;25(12):1385-96. DM53O9Y RU https://www.ncbi.nlm.nih.gov/pubmed/26293650 DMCKBGM DI DMCKBGM DMCKBGM DN Pyrimidinyl compound 5 DMCKBGM MI TTH5TC2 DMCKBGM MN NF-kappa-B-activating kinase (TBK1) DMCKBGM MT DTT DMCKBGM MA Inhibitor DMCKBGM RN TBK1 inhibitors: a review of patent literature (2011 - 2014).Expert Opin Ther Pat. 2015;25(12):1385-96. DMCKBGM RU https://www.ncbi.nlm.nih.gov/pubmed/26293650 DML2E8S DI DML2E8S DML2E8S DN Pyrimidinyl compound 6 DML2E8S MI TTH5TC2 DML2E8S MN NF-kappa-B-activating kinase (TBK1) DML2E8S MT DTT DML2E8S MA Inhibitor DML2E8S RN TBK1 inhibitors: a review of patent literature (2011 - 2014).Expert Opin Ther Pat. 2015;25(12):1385-96. DML2E8S RU https://www.ncbi.nlm.nih.gov/pubmed/26293650 DMMYW2L DI DMMYW2L DMMYW2L DN Pyrimidinyl compound 7 DMMYW2L MI TTH5TC2 DMMYW2L MN NF-kappa-B-activating kinase (TBK1) DMMYW2L MT DTT DMMYW2L MA Inhibitor DMMYW2L RN TBK1 inhibitors: a review of patent literature (2011 - 2014).Expert Opin Ther Pat. 2015;25(12):1385-96. DMMYW2L RU https://www.ncbi.nlm.nih.gov/pubmed/26293650 DMZ83P1 DI DMZ83P1 DMZ83P1 DN Pyrimidinyl ethylenediamine derivative 1 DMZ83P1 MI TTDP1UC DMZ83P1 MN Fatty acid amide hydrolase (FAAH) DMZ83P1 MT DTT DMZ83P1 MA Inhibitor DMZ83P1 RN Fatty acid amide hydrolase inhibitors: a patent review (2009-2014).Expert Opin Ther Pat. 2015;25(11):1247-66. DMZ83P1 RU https://www.ncbi.nlm.nih.gov/pubmed/26413912 DMZ83P1 DI DMZ83P1 DMZ83P1 DN Pyrimidinyl ethylenediamine derivative 1 DMZ83P1 MI TTGX13H DMZ83P1 MN Fatty-acid amide hydrolase 1 (FAAH1) DMZ83P1 MT DTT DMZ83P1 MA Inhibitor DMZ83P1 RN Fatty acid amide hydrolase inhibitors: a patent review (2009-2014).Expert Opin Ther Pat. 2015;25(11):1247-66. DMZ83P1 RU https://www.ncbi.nlm.nih.gov/pubmed/26413912 DM72T58 DI DM72T58 DM72T58 DN Pyrimidinyl pyrazolamine derivative 1 DM72T58 MI TTS7G69 DM72T58 MN Fusion protein Bcr-Abl (Bcr-Abl) DM72T58 MT DTT DM72T58 MA Inhibitor DM72T58 RN Bcr-Abl tyrosine kinase inhibitors: a patent review.Expert Opin Ther Pat. 2015 Apr;25(4):397-412. DM72T58 RU https://www.ncbi.nlm.nih.gov/pubmed/25656651 DM6O2Q9 DI DM6O2Q9 DM6O2Q9 DN Pyrimido[4,5-d] pyrimidines and pyrido[4,3-d] pyrimidine derivative 1 DM6O2Q9 MI TTG0U4H DM6O2Q9 MN Ribosomal protein S6 kinase beta-1 (S6K1) DM6O2Q9 MT DTT DM6O2Q9 MA Inhibitor DM6O2Q9 RN Ribosomal S6 kinase (RSK) modulators: a patent review.Expert Opin Ther Pat. 2016 Sep;26(9):1061-78. DM6O2Q9 RU https://www.ncbi.nlm.nih.gov/pubmed/27410995 DMB5UF7 DI DMB5UF7 DMB5UF7 DN Pyrimido-indole derivative 1 DMB5UF7 MI TTE4BSY DMB5UF7 MN Bromodomain and extraterminal domain protein (BET) DMB5UF7 MT DTT DMB5UF7 MA Inhibitor DMB5UF7 RN BET inhibitors in cancer therapeutics: a patent review.Expert Opin Ther Pat. 2016;26(4):505-22. DMB5UF7 RU https://www.ncbi.nlm.nih.gov/pubmed/26924192 DM3REN5 DI DM3REN5 DM3REN5 DN Pyrimido-indole derivative 2 DM3REN5 MI TTE4BSY DM3REN5 MN Bromodomain and extraterminal domain protein (BET) DM3REN5 MT DTT DM3REN5 MA Inhibitor DM3REN5 RN BET inhibitors in cancer therapeutics: a patent review.Expert Opin Ther Pat. 2016;26(4):505-22. DM3REN5 RU https://www.ncbi.nlm.nih.gov/pubmed/26924192 DM53LGD DI DM53LGD DM53LGD DN Pyrimido-indole derivative 3 DM53LGD MI TTE4BSY DM53LGD MN Bromodomain and extraterminal domain protein (BET) DM53LGD MT DTT DM53LGD MA Inhibitor DM53LGD RN BET inhibitors in cancer therapeutics: a patent review.Expert Opin Ther Pat. 2016;26(4):505-22. DM53LGD RU https://www.ncbi.nlm.nih.gov/pubmed/26924192 DM32N7D DI DM32N7D DM32N7D DN Pyrimidopyridazinone derivative 1 DM32N7D MI TTRMX3V DM32N7D MN Janus kinase 2 (JAK-2) DM32N7D MT DTT DM32N7D MA Inhibitor DM32N7D RN Inhibitors of JAK-family kinases: an update on the patent literature 2013-2015, part 1.Expert Opin Ther Pat. 2017 Feb;27(2):127-143. DM32N7D RU https://www.ncbi.nlm.nih.gov/pubmed/27774824 DM32N7D DI DM32N7D DM32N7D DN Pyrimidopyridazinone derivative 1 DM32N7D MI TTOU65C DM32N7D MN Tyrosine-protein kinase SYK (SYK) DM32N7D MT DTT DM32N7D MA Inhibitor DM32N7D RN Inhibitors of JAK-family kinases: an update on the patent literature 2013-2015, part 1.Expert Opin Ther Pat. 2017 Feb;27(2):127-143. DM32N7D RU https://www.ncbi.nlm.nih.gov/pubmed/27774824 DMD1RT0 DI DMD1RT0 DMD1RT0 DN Pyrimidopyridazinone derivative 2 DMD1RT0 MI TT6DM01 DMD1RT0 MN Janus kinase 1 (JAK-1) DMD1RT0 MT DTT DMD1RT0 MA Inhibitor DMD1RT0 RN Inhibitors of JAK-family kinases: an update on the patent literature 2013-2015, part 1.Expert Opin Ther Pat. 2017 Feb;27(2):127-143. DMD1RT0 RU https://www.ncbi.nlm.nih.gov/pubmed/27774824 DMD1RT0 DI DMD1RT0 DMD1RT0 DN Pyrimidopyridazinone derivative 2 DMD1RT0 MI TTRMX3V DMD1RT0 MN Janus kinase 2 (JAK-2) DMD1RT0 MT DTT DMD1RT0 MA Inhibitor DMD1RT0 RN Inhibitors of JAK-family kinases: an update on the patent literature 2013-2015, part 1.Expert Opin Ther Pat. 2017 Feb;27(2):127-143. DMD1RT0 RU https://www.ncbi.nlm.nih.gov/pubmed/27774824 DMD1RT0 DI DMD1RT0 DMD1RT0 DN Pyrimidopyridazinone derivative 2 DMD1RT0 MI TTT7PJU DMD1RT0 MN Janus kinase 3 (JAK-3) DMD1RT0 MT DTT DMD1RT0 MA Inhibitor DMD1RT0 RN Inhibitors of JAK-family kinases: an update on the patent literature 2013-2015, part 1.Expert Opin Ther Pat. 2017 Feb;27(2):127-143. DMD1RT0 RU https://www.ncbi.nlm.nih.gov/pubmed/27774824 DMD1RT0 DI DMD1RT0 DMD1RT0 DN Pyrimidopyridazinone derivative 2 DMD1RT0 MI TTOU65C DMD1RT0 MN Tyrosine-protein kinase SYK (SYK) DMD1RT0 MT DTT DMD1RT0 MA Inhibitor DMD1RT0 RN Inhibitors of JAK-family kinases: an update on the patent literature 2013-2015, part 1.Expert Opin Ther Pat. 2017 Feb;27(2):127-143. DMD1RT0 RU https://www.ncbi.nlm.nih.gov/pubmed/27774824 DM0RC1Z DI DM0RC1Z DM0RC1Z DN Pyrrole derivative 1 DM0RC1Z MI TT6OEDT DM0RC1Z MN Cannabinoid receptor 1 (CB1) DM0RC1Z MT DTT DM0RC1Z MA Antagonist DM0RC1Z RN A comprehensive patents review on cannabinoid 1 receptor antagonists as antiobesity agents. Expert Opin Ther Pat. 2015 Oct;25(10):1093-116. DM0RC1Z RU https://pubmed.ncbi.nlm.nih.gov/26161824 DMMNKFX DI DMMNKFX DMMNKFX DN Pyrrole derivative 2 DMMNKFX MI TT6OEDT DMMNKFX MN Cannabinoid receptor 1 (CB1) DMMNKFX MT DTT DMMNKFX MA Antagonist DMMNKFX RN A comprehensive patents review on cannabinoid 1 receptor antagonists as antiobesity agents. Expert Opin Ther Pat. 2015 Oct;25(10):1093-116. DMMNKFX RU https://pubmed.ncbi.nlm.nih.gov/26161824 DMFV64B DI DMFV64B DMFV64B DN Pyrrole derivative 3 DMFV64B MI TT6OEDT DMFV64B MN Cannabinoid receptor 1 (CB1) DMFV64B MT DTT DMFV64B MA Antagonist DMFV64B RN A comprehensive patents review on cannabinoid 1 receptor antagonists as antiobesity agents. Expert Opin Ther Pat. 2015 Oct;25(10):1093-116. DMFV64B RU https://pubmed.ncbi.nlm.nih.gov/26161824 DMQDL43 DI DMQDL43 DMQDL43 DN Pyrrole derivative 4 DMQDL43 MI TT6OEDT DMQDL43 MN Cannabinoid receptor 1 (CB1) DMQDL43 MT DTT DMQDL43 MA Antagonist DMQDL43 RN A comprehensive patents review on cannabinoid 1 receptor antagonists as antiobesity agents. Expert Opin Ther Pat. 2015 Oct;25(10):1093-116. DMQDL43 RU https://pubmed.ncbi.nlm.nih.gov/26161824 DMJUMC6 DI DMJUMC6 DMJUMC6 DN Pyrrole derivative 5 DMJUMC6 MI TT6OEDT DMJUMC6 MN Cannabinoid receptor 1 (CB1) DMJUMC6 MT DTT DMJUMC6 MA Antagonist DMJUMC6 RN A comprehensive patents review on cannabinoid 1 receptor antagonists as antiobesity agents. Expert Opin Ther Pat. 2015 Oct;25(10):1093-116. DMJUMC6 RU https://pubmed.ncbi.nlm.nih.gov/26161824 DM875RE DI DM875RE DM875RE DN Pyrrole derivative 6 DM875RE MI TT6OEDT DM875RE MN Cannabinoid receptor 1 (CB1) DM875RE MT DTT DM875RE MA Antagonist DM875RE RN A comprehensive patents review on cannabinoid 1 receptor antagonists as antiobesity agents. Expert Opin Ther Pat. 2015 Oct;25(10):1093-116. DM875RE RU https://pubmed.ncbi.nlm.nih.gov/26161824 DMZCERW DI DMZCERW DMZCERW DN Pyrrole derivative 7 DMZCERW MI TT6DM01 DMZCERW MN Janus kinase 1 (JAK-1) DMZCERW MT DTT DMZCERW MA Inhibitor DMZCERW RN Inhibitors of JAK-family kinases: an update on the patent literature 2013-2015, part 2.Expert Opin Ther Pat. 2017 Feb;27(2):145-161. DMZCERW RU https://www.ncbi.nlm.nih.gov/pubmed/27774822 DMZCERW DI DMZCERW DMZCERW DN Pyrrole derivative 7 DMZCERW MI TTRMX3V DMZCERW MN Janus kinase 2 (JAK-2) DMZCERW MT DTT DMZCERW MA Inhibitor DMZCERW RN Inhibitors of JAK-family kinases: an update on the patent literature 2013-2015, part 2.Expert Opin Ther Pat. 2017 Feb;27(2):145-161. DMZCERW RU https://www.ncbi.nlm.nih.gov/pubmed/27774822 DMZCERW DI DMZCERW DMZCERW DN Pyrrole derivative 7 DMZCERW MI TTBYWP2 DMZCERW MN TYK2 tyrosine kinase (TYK2) DMZCERW MT DTT DMZCERW MA Inhibitor DMZCERW RN Inhibitors of JAK-family kinases: an update on the patent literature 2013-2015, part 2.Expert Opin Ther Pat. 2017 Feb;27(2):145-161. DMZCERW RU https://www.ncbi.nlm.nih.gov/pubmed/27774822 DM1A0VB DI DM1A0VB DM1A0VB DN Pyrrole six-membered heteroaryl ring derivative 1 DM1A0VB MI TT6DM01 DM1A0VB MN Janus kinase 1 (JAK-1) DM1A0VB MT DTT DM1A0VB MA Inhibitor DM1A0VB RN Inhibitors of JAK-family kinases: an update on the patent literature 2013-2015, part 2.Expert Opin Ther Pat. 2017 Feb;27(2):145-161. DM1A0VB RU https://www.ncbi.nlm.nih.gov/pubmed/27774822 DM1A0VB DI DM1A0VB DM1A0VB DN Pyrrole six-membered heteroaryl ring derivative 1 DM1A0VB MI TTRMX3V DM1A0VB MN Janus kinase 2 (JAK-2) DM1A0VB MT DTT DM1A0VB MA Inhibitor DM1A0VB RN Inhibitors of JAK-family kinases: an update on the patent literature 2013-2015, part 2.Expert Opin Ther Pat. 2017 Feb;27(2):145-161. DM1A0VB RU https://www.ncbi.nlm.nih.gov/pubmed/27774822 DM1A0VB DI DM1A0VB DM1A0VB DN Pyrrole six-membered heteroaryl ring derivative 1 DM1A0VB MI TTT7PJU DM1A0VB MN Janus kinase 3 (JAK-3) DM1A0VB MT DTT DM1A0VB MA Inhibitor DM1A0VB RN Inhibitors of JAK-family kinases: an update on the patent literature 2013-2015, part 2.Expert Opin Ther Pat. 2017 Feb;27(2):145-161. DM1A0VB RU https://www.ncbi.nlm.nih.gov/pubmed/27774822 DMJK98Z DI DMJK98Z DMJK98Z DN Pyrrolidine carboxamide derivative 1 DMJK98Z MI TTQHWNA DMJK98Z MN Hypoxia-inducible factor 1 alpha (HIF-1A) DMJK98Z MT DTT DMJK98Z MA Inhibitor DMJK98Z RN Hypoxia-inducible factor (HIF) inhibitors: a patent survey (2011-2015).Expert Opin Ther Pat. 2016;26(3):309-22. DMJK98Z RU https://www.ncbi.nlm.nih.gov/pubmed/26882240 DMJK98Z DI DMJK98Z DMJK98Z DN Pyrrolidine carboxamide derivative 1 DMJK98Z MI TTEMWSD DMJK98Z MN von Hippel-Lindau disease tumor suppressor (VHL) DMJK98Z MT DTT DMJK98Z MA Inhibitor DMJK98Z RN Hypoxia-inducible factor (HIF) inhibitors: a patent survey (2011-2015).Expert Opin Ther Pat. 2016;26(3):309-22. DMJK98Z RU https://www.ncbi.nlm.nih.gov/pubmed/26882240 DMKDX6W DI DMKDX6W DMKDX6W DN Pyrrolidine carboxamide derivative 2 DMKDX6W MI TTTJZ4M DMKDX6W MN Prolylcarboxypeptidase (PRCP) DMKDX6W MT DTT DMKDX6W MA Inhibitor DMKDX6W RN Prolylcarboxypeptidase (PrCP) inhibitors and the therapeutic uses thereof: a patent review.Expert Opin Ther Pat. 2017 Oct;27(10):1077-1088. DMKDX6W RU https://www.ncbi.nlm.nih.gov/pubmed/28699813 DMXALJE DI DMXALJE DMXALJE DN Pyrrolidine derivative 1 DMXALJE MI TTHS256 DMXALJE MN Metabotropic glutamate receptor 5 (mGluR5) DMXALJE MT DTT DMXALJE RN mGlu5 negative allosteric modulators: a patent review (2013 - 2016).Expert Opin Ther Pat. 2017 Jun;27(6):691-706. DMXALJE RU https://www.ncbi.nlm.nih.gov/pubmed/28067079 DMCQN5M DI DMCQN5M DMCQN5M DN Pyrrolidine derivative 10 DMCQN5M MI TTSCIUP DMCQN5M MN Oxytocin receptor (OTR) DMCQN5M MT DTT DMCQN5M MA Antagonist DMCQN5M RN A patent review of oxytocin receptor antagonists 2013-2017.Expert Opin Ther Pat. 2017 Dec;27(12):1287-1290. DMCQN5M RU https://www.ncbi.nlm.nih.gov/pubmed/28906174 DMIHRV9 DI DMIHRV9 DMIHRV9 DN Pyrrolidine derivative 11 DMIHRV9 MI TTSCIUP DMIHRV9 MN Oxytocin receptor (OTR) DMIHRV9 MT DTT DMIHRV9 MA Antagonist DMIHRV9 RN A patent review of oxytocin receptor antagonists 2013-2017.Expert Opin Ther Pat. 2017 Dec;27(12):1287-1290. DMIHRV9 RU https://www.ncbi.nlm.nih.gov/pubmed/28906174 DMXO8R5 DI DMXO8R5 DMXO8R5 DN Pyrrolidine derivative 12 DMXO8R5 MI TTSCIUP DMXO8R5 MN Oxytocin receptor (OTR) DMXO8R5 MT DTT DMXO8R5 MA Antagonist DMXO8R5 RN A patent review of oxytocin receptor antagonists 2013-2017.Expert Opin Ther Pat. 2017 Dec;27(12):1287-1290. DMXO8R5 RU https://www.ncbi.nlm.nih.gov/pubmed/28906174 DM3VA8P DI DM3VA8P DM3VA8P DN Pyrrolidine derivative 13 DM3VA8P MI TTSCIUP DM3VA8P MN Oxytocin receptor (OTR) DM3VA8P MT DTT DM3VA8P MA Antagonist DM3VA8P RN A patent review of oxytocin receptor antagonists 2013-2017.Expert Opin Ther Pat. 2017 Dec;27(12):1287-1290. DM3VA8P RU https://www.ncbi.nlm.nih.gov/pubmed/28906174 DM3VA8P DI DM3VA8P DM3VA8P DN Pyrrolidine derivative 13 DM3VA8P MI TT4TFGN DM3VA8P MN Vasopressin V1a receptor (V1AR) DM3VA8P MT DTT DM3VA8P MA Antagonist DM3VA8P RN A patent review of oxytocin receptor antagonists 2013-2017.Expert Opin Ther Pat. 2017 Dec;27(12):1287-1290. DM3VA8P RU https://www.ncbi.nlm.nih.gov/pubmed/28906174 DM5WA29 DI DM5WA29 DM5WA29 DN Pyrrolidine derivative 2 DM5WA29 MI TTHS256 DM5WA29 MN Metabotropic glutamate receptor 5 (mGluR5) DM5WA29 MT DTT DM5WA29 RN mGlu5 negative allosteric modulators: a patent review (2013 - 2016).Expert Opin Ther Pat. 2017 Jun;27(6):691-706. DM5WA29 RU https://www.ncbi.nlm.nih.gov/pubmed/28067079 DMHM8WJ DI DMHM8WJ DMHM8WJ DN Pyrrolidine derivative 3 DMHM8WJ MI TTHS256 DMHM8WJ MN Metabotropic glutamate receptor 5 (mGluR5) DMHM8WJ MT DTT DMHM8WJ RN mGlu5 negative allosteric modulators: a patent review (2013 - 2016).Expert Opin Ther Pat. 2017 Jun;27(6):691-706. DMHM8WJ RU https://www.ncbi.nlm.nih.gov/pubmed/28067079 DMZ2HBL DI DMZ2HBL DMZ2HBL DN Pyrrolidine derivative 4 DMZ2HBL MI TTHS256 DMZ2HBL MN Metabotropic glutamate receptor 5 (mGluR5) DMZ2HBL MT DTT DMZ2HBL RN mGlu5 negative allosteric modulators: a patent review (2013 - 2016).Expert Opin Ther Pat. 2017 Jun;27(6):691-706. DMZ2HBL RU https://www.ncbi.nlm.nih.gov/pubmed/28067079 DM5NKXO DI DM5NKXO DM5NKXO DN Pyrrolidine derivative 5 DM5NKXO MI TTHS256 DM5NKXO MN Metabotropic glutamate receptor 5 (mGluR5) DM5NKXO MT DTT DM5NKXO RN mGlu5 negative allosteric modulators: a patent review (2013 - 2016).Expert Opin Ther Pat. 2017 Jun;27(6):691-706. DM5NKXO RU https://www.ncbi.nlm.nih.gov/pubmed/28067079 DMJ3ZP2 DI DMJ3ZP2 DMJ3ZP2 DN Pyrrolidine derivative 6 DMJ3ZP2 MI TT9O6WS DMJ3ZP2 MN Glucagon receptor (GCGR) DMJ3ZP2 MT DTT DMJ3ZP2 MA Antagonist DMJ3ZP2 RN Small molecule glucagon receptor antagonists: a patent review (2011 - 2014).Expert Opin Ther Pat. 2015 Jul;25(7):819-30. DMJ3ZP2 RU https://www.ncbi.nlm.nih.gov/pubmed/25828189 DMIOJD6 DI DMIOJD6 DMIOJD6 DN Pyrrolidine derivative 7 DMIOJD6 MI TT9O6WS DMIOJD6 MN Glucagon receptor (GCGR) DMIOJD6 MT DTT DMIOJD6 MA Antagonist DMIOJD6 RN Small molecule glucagon receptor antagonists: a patent review (2011 - 2014).Expert Opin Ther Pat. 2015 Jul;25(7):819-30. DMIOJD6 RU https://www.ncbi.nlm.nih.gov/pubmed/25828189 DMWPXJ5 DI DMWPXJ5 DMWPXJ5 DN Pyrrolidine derivative 8 DMWPXJ5 MI TT9O6WS DMWPXJ5 MN Glucagon receptor (GCGR) DMWPXJ5 MT DTT DMWPXJ5 MA Antagonist DMWPXJ5 RN Small molecule glucagon receptor antagonists: a patent review (2011 - 2014).Expert Opin Ther Pat. 2015 Jul;25(7):819-30. DMWPXJ5 RU https://www.ncbi.nlm.nih.gov/pubmed/25828189 DMZK658 DI DMZK658 DMZK658 DN Pyrrolidine derivative 9 DMZK658 MI TTSCIUP DMZK658 MN Oxytocin receptor (OTR) DMZK658 MT DTT DMZK658 MA Antagonist DMZK658 RN A patent review of oxytocin receptor antagonists 2013-2017.Expert Opin Ther Pat. 2017 Dec;27(12):1287-1290. DMZK658 RU https://www.ncbi.nlm.nih.gov/pubmed/28906174 DM7DF6Z DI DM7DF6Z DM7DF6Z DN Pyrrolidinyl urea derivative 1 DM7DF6Z MI TTDP1UC DM7DF6Z MN Fatty acid amide hydrolase (FAAH) DM7DF6Z MT DTT DM7DF6Z MA Inhibitor DM7DF6Z RN Fatty acid amide hydrolase inhibitors: a patent review (2009-2014).Expert Opin Ther Pat. 2015;25(11):1247-66. DM7DF6Z RU https://www.ncbi.nlm.nih.gov/pubmed/26413912 DMV6YXJ DI DMV6YXJ DMV6YXJ DN Pyrrolidinyl urea derivative 10 DMV6YXJ MI TTTDVOJ DMV6YXJ MN Tropomyosin-related kinase A (TrkA) DMV6YXJ MT DTT DMV6YXJ MA Inhibitor DMV6YXJ RN Tropomyosin receptor kinase inhibitors: an updated patent review for 2010-2016 - Part I.Expert Opin Ther Pat. 2017 Jun;27(6):733-751. DMV6YXJ RU https://www.ncbi.nlm.nih.gov/pubmed/28270010 DMWKSF3 DI DMWKSF3 DMWKSF3 DN Pyrrolidinyl urea derivative 11 DMWKSF3 MI TTTDVOJ DMWKSF3 MN Tropomyosin-related kinase A (TrkA) DMWKSF3 MT DTT DMWKSF3 MA Inhibitor DMWKSF3 RN Tropomyosin receptor kinase inhibitors: an updated patent review for 2010-2016 - Part I.Expert Opin Ther Pat. 2017 Jun;27(6):733-751. DMWKSF3 RU https://www.ncbi.nlm.nih.gov/pubmed/28270010 DMJ6IE5 DI DMJ6IE5 DMJ6IE5 DN Pyrrolidinyl urea derivative 12 DMJ6IE5 MI TTTDVOJ DMJ6IE5 MN Tropomyosin-related kinase A (TrkA) DMJ6IE5 MT DTT DMJ6IE5 MA Inhibitor DMJ6IE5 RN Tropomyosin receptor kinase inhibitors: an updated patent review for 2010-2016 - Part I.Expert Opin Ther Pat. 2017 Jun;27(6):733-751. DMJ6IE5 RU https://www.ncbi.nlm.nih.gov/pubmed/28270010 DM3VL82 DI DM3VL82 DM3VL82 DN Pyrrolidinyl urea derivative 13 DM3VL82 MI TTTDVOJ DM3VL82 MN Tropomyosin-related kinase A (TrkA) DM3VL82 MT DTT DM3VL82 MA Inhibitor DM3VL82 RN Tropomyosin receptor kinase inhibitors: an updated patent review for 2010-2016 - Part I.Expert Opin Ther Pat. 2017 Jun;27(6):733-751. DM3VL82 RU https://www.ncbi.nlm.nih.gov/pubmed/28270010 DMYFP95 DI DMYFP95 DMYFP95 DN Pyrrolidinyl urea derivative 2 DMYFP95 MI TTTDVOJ DMYFP95 MN Tropomyosin-related kinase A (TrkA) DMYFP95 MT DTT DMYFP95 MA Inhibitor DMYFP95 RN Tropomyosin receptor kinase inhibitors: an updated patent review for 2010-2016 - Part I.Expert Opin Ther Pat. 2017 Jun;27(6):733-751. DMYFP95 RU https://www.ncbi.nlm.nih.gov/pubmed/28270010 DMFDLHN DI DMFDLHN DMFDLHN DN Pyrrolidinyl urea derivative 3 DMFDLHN MI TTTDVOJ DMFDLHN MN Tropomyosin-related kinase A (TrkA) DMFDLHN MT DTT DMFDLHN MA Inhibitor DMFDLHN RN Tropomyosin receptor kinase inhibitors: an updated patent review for 2010-2016 - Part I.Expert Opin Ther Pat. 2017 Jun;27(6):733-751. DMFDLHN RU https://www.ncbi.nlm.nih.gov/pubmed/28270010 DM8SZKU DI DM8SZKU DM8SZKU DN Pyrrolidinyl urea derivative 4 DM8SZKU MI TTTDVOJ DM8SZKU MN Tropomyosin-related kinase A (TrkA) DM8SZKU MT DTT DM8SZKU MA Inhibitor DM8SZKU RN Tropomyosin receptor kinase inhibitors: an updated patent review for 2010-2016 - Part I.Expert Opin Ther Pat. 2017 Jun;27(6):733-751. DM8SZKU RU https://www.ncbi.nlm.nih.gov/pubmed/28270010 DMU51T4 DI DMU51T4 DMU51T4 DN Pyrrolidinyl urea derivative 5 DMU51T4 MI TTTDVOJ DMU51T4 MN Tropomyosin-related kinase A (TrkA) DMU51T4 MT DTT DMU51T4 MA Inhibitor DMU51T4 RN Tropomyosin receptor kinase inhibitors: an updated patent review for 2010-2016 - Part I.Expert Opin Ther Pat. 2017 Jun;27(6):733-751. DMU51T4 RU https://www.ncbi.nlm.nih.gov/pubmed/28270010 DM01GEB DI DM01GEB DM01GEB DN Pyrrolidinyl urea derivative 6 DM01GEB MI TTTDVOJ DM01GEB MN Tropomyosin-related kinase A (TrkA) DM01GEB MT DTT DM01GEB MA Inhibitor DM01GEB RN Tropomyosin receptor kinase inhibitors: an updated patent review for 2010-2016 - Part I.Expert Opin Ther Pat. 2017 Jun;27(6):733-751. DM01GEB RU https://www.ncbi.nlm.nih.gov/pubmed/28270010 DMYADJP DI DMYADJP DMYADJP DN Pyrrolidinyl urea derivative 7 DMYADJP MI TTTDVOJ DMYADJP MN Tropomyosin-related kinase A (TrkA) DMYADJP MT DTT DMYADJP MA Inhibitor DMYADJP RN Tropomyosin receptor kinase inhibitors: an updated patent review for 2010-2016 - Part I.Expert Opin Ther Pat. 2017 Jun;27(6):733-751. DMYADJP RU https://www.ncbi.nlm.nih.gov/pubmed/28270010 DMW2JG8 DI DMW2JG8 DMW2JG8 DN Pyrrolidinyl urea derivative 8 DMW2JG8 MI TTTDVOJ DMW2JG8 MN Tropomyosin-related kinase A (TrkA) DMW2JG8 MT DTT DMW2JG8 MA Inhibitor DMW2JG8 RN Tropomyosin receptor kinase inhibitors: an updated patent review for 2010-2016 - Part I.Expert Opin Ther Pat. 2017 Jun;27(6):733-751. DMW2JG8 RU https://www.ncbi.nlm.nih.gov/pubmed/28270010 DMO1I4W DI DMO1I4W DMO1I4W DN Pyrrolidinyl urea derivative 9 DMO1I4W MI TTTDVOJ DMO1I4W MN Tropomyosin-related kinase A (TrkA) DMO1I4W MT DTT DMO1I4W MA Inhibitor DMO1I4W RN Tropomyosin receptor kinase inhibitors: an updated patent review for 2010-2016 - Part I.Expert Opin Ther Pat. 2017 Jun;27(6):733-751. DMO1I4W RU https://www.ncbi.nlm.nih.gov/pubmed/28270010 DM5RCW8 DI DM5RCW8 DM5RCW8 DN Pyrrolo[1,2-c]pyrazole derivative 1 DM5RCW8 MI TTZJYKH DM5RCW8 MN Indoleamine 2,3-dioxygenase 1 (IDO1) DM5RCW8 MT DTT DM5RCW8 MA Inhibitor DM5RCW8 RN A patent review of IDO1 inhibitors for cancer.Expert Opin Ther Pat. 2018 Apr;28(4):317-330. DM5RCW8 RU https://www.ncbi.nlm.nih.gov/pubmed/29473428 DMI0AW7 DI DMI0AW7 DMI0AW7 DN Pyrrolo[1,2-f]triazine derivative 1 DMI0AW7 MI TTDIGC1 DMI0AW7 MN Dipeptidyl peptidase 4 (DPP-4) DMI0AW7 MT DTT DMI0AW7 MA Inhibitor DMI0AW7 RN DPP-4 inhibitors: a patent review (2012 - 2014).Expert Opin Ther Pat. 2015 Feb;25(2):209-36. DMI0AW7 RU https://www.ncbi.nlm.nih.gov/pubmed/25482888 DM7DU9P DI DM7DU9P DM7DU9P DN Pyrrolo[1,2-f]triazine derivative 2 DM7DU9P MI TTDIGC1 DM7DU9P MN Dipeptidyl peptidase 4 (DPP-4) DM7DU9P MT DTT DM7DU9P MA Inhibitor DM7DU9P RN DPP-4 inhibitors: a patent review (2012 - 2014).Expert Opin Ther Pat. 2015 Feb;25(2):209-36. DM7DU9P RU https://www.ncbi.nlm.nih.gov/pubmed/25482888 DMWXZBF DI DMWXZBF DMWXZBF DN Pyrrolo[2,3-b]pyridine carboxamide derivative 1 DMWXZBF MI TTS7G69 DMWXZBF MN Fusion protein Bcr-Abl (Bcr-Abl) DMWXZBF MT DTT DMWXZBF MA Inhibitor DMWXZBF RN Bcr-Abl tyrosine kinase inhibitors: a patent review.Expert Opin Ther Pat. 2015 Apr;25(4):397-412. DMWXZBF RU https://www.ncbi.nlm.nih.gov/pubmed/25656651 DMVKCQU DI DMVKCQU DMVKCQU DN Pyrrolo[2,3-b]pyridine derivative 1 DMVKCQU MI TTTDVOJ DMVKCQU MN Tropomyosin-related kinase A (TrkA) DMVKCQU MT DTT DMVKCQU MA Inhibitor DMVKCQU RN Tropomyosin receptor kinase inhibitors: an updated patent review for 2010-2016 - Part II.Expert Opin Ther Pat. 2017 Jul;27(7):831-849. DMVKCQU RU https://www.ncbi.nlm.nih.gov/pubmed/28270021 DM7IPWB DI DM7IPWB DM7IPWB DN Pyrrolo[2,3-b]pyridine derivative 2 DM7IPWB MI TTTDVOJ DM7IPWB MN Tropomyosin-related kinase A (TrkA) DM7IPWB MT DTT DM7IPWB MA Inhibitor DM7IPWB RN Tropomyosin receptor kinase inhibitors: an updated patent review for 2010-2016 - Part II.Expert Opin Ther Pat. 2017 Jul;27(7):831-849. DM7IPWB RU https://www.ncbi.nlm.nih.gov/pubmed/28270021 DMCYOL7 DI DMCYOL7 DMCYOL7 DN Pyrrolo[2,3-b]pyridine derivative 3 DMCYOL7 MI TTTDVOJ DMCYOL7 MN Tropomyosin-related kinase A (TrkA) DMCYOL7 MT DTT DMCYOL7 MA Inhibitor DMCYOL7 RN Tropomyosin receptor kinase inhibitors: an updated patent review for 2010-2016 - Part II.Expert Opin Ther Pat. 2017 Jul;27(7):831-849. DMCYOL7 RU https://www.ncbi.nlm.nih.gov/pubmed/28270021 DMJBTZG DI DMJBTZG DMJBTZG DN Pyrrolo[2,3-b]pyridine derivative 4 DMJBTZG MI TTIV39N DMJBTZG MN Fusion protein Bcr-Abl T315I mutant (Bcr-Abl T315I) DMJBTZG MT DTT DMJBTZG MA Inhibitor DMJBTZG RN Bcr-Abl tyrosine kinase inhibitors: a patent review.Expert Opin Ther Pat. 2015 Apr;25(4):397-412. DMJBTZG RU https://www.ncbi.nlm.nih.gov/pubmed/25656651 DMYUEA6 DI DMYUEA6 DMYUEA6 DN Pyrrolo[2,3-d]pyrimidine derivative 1 DMYUEA6 MI TTIXKA4 DMYUEA6 MN Ribosomal protein S6 kinase alpha-1 (RSK1) DMYUEA6 MT DTT DMYUEA6 MA Inhibitor DMYUEA6 RN Ribosomal S6 kinase (RSK) modulators: a patent review.Expert Opin Ther Pat. 2016 Sep;26(9):1061-78. DMYUEA6 RU https://www.ncbi.nlm.nih.gov/pubmed/27410995 DMRWG2E DI DMRWG2E DMRWG2E DN Pyrrolo[2,3-d]pyrimidine derivative 10 DMRWG2E MI TTH6V3D DMRWG2E MN Cyclin-dependent kinase 1 (CDK1) DMRWG2E MT DTT DMRWG2E MA Inhibitor DMRWG2E RN Cyclin-dependent kinase inhibitors for cancer therapy: a patent review (2009 - 2014).Expert Opin Ther Pat. 2015;25(9):953-70. DMRWG2E RU https://www.ncbi.nlm.nih.gov/pubmed/26161698 DMRWG2E DI DMRWG2E DMRWG2E DN Pyrrolo[2,3-d]pyrimidine derivative 10 DMRWG2E MI TT0PG8F DMRWG2E MN Cyclin-dependent kinase 4 (CDK4) DMRWG2E MT DTT DMRWG2E MA Inhibitor DMRWG2E RN Cyclin-dependent kinase inhibitors for cancer therapy: a patent review (2009 - 2014).Expert Opin Ther Pat. 2015;25(9):953-70. DMRWG2E RU https://www.ncbi.nlm.nih.gov/pubmed/26161698 DM983CY DI DM983CY DM983CY DN Pyrrolo[2,3-d]pyrimidine derivative 11 DM983CY MI TT6DM01 DM983CY MN Janus kinase 1 (JAK-1) DM983CY MT DTT DM983CY MA Inhibitor DM983CY RN Inhibitors of JAK-family kinases: an update on the patent literature 2013-2015, part 1.Expert Opin Ther Pat. 2017 Feb;27(2):127-143. DM983CY RU https://www.ncbi.nlm.nih.gov/pubmed/27774824 DM983CY DI DM983CY DM983CY DN Pyrrolo[2,3-d]pyrimidine derivative 11 DM983CY MI TTRMX3V DM983CY MN Janus kinase 2 (JAK-2) DM983CY MT DTT DM983CY MA Inhibitor DM983CY RN Inhibitors of JAK-family kinases: an update on the patent literature 2013-2015, part 1.Expert Opin Ther Pat. 2017 Feb;27(2):127-143. DM983CY RU https://www.ncbi.nlm.nih.gov/pubmed/27774824 DMYTV49 DI DMYTV49 DMYTV49 DN Pyrrolo[2,3-d]pyrimidine derivative 12 DMYTV49 MI TTGM6VW DMYTV49 MN Tyrosine-protein kinase BTK (ATK) DMYTV49 MT DTT DMYTV49 MA Inhibitor DMYTV49 RN Pyrrolo[2,3-d]pyrimidines active as Btk inhibitors.Expert Opin Ther Pat. 2017 Dec;27(12):1305-1318. DMYTV49 RU https://www.ncbi.nlm.nih.gov/pubmed/28705083 DMTGELI DI DMTGELI DMTGELI DN Pyrrolo[2,3-d]pyrimidine derivative 13 DMTGELI MI TTGM6VW DMTGELI MN Tyrosine-protein kinase BTK (ATK) DMTGELI MT DTT DMTGELI MA Inhibitor DMTGELI RN Pyrrolo[2,3-d]pyrimidines active as Btk inhibitors.Expert Opin Ther Pat. 2017 Dec;27(12):1305-1318. DMTGELI RU https://www.ncbi.nlm.nih.gov/pubmed/28705083 DMK4LOH DI DMK4LOH DMK4LOH DN Pyrrolo[2,3-d]pyrimidine derivative 14 DMK4LOH MI TTGM6VW DMK4LOH MN Tyrosine-protein kinase BTK (ATK) DMK4LOH MT DTT DMK4LOH MA Inhibitor DMK4LOH RN Pyrrolo[2,3-d]pyrimidines active as Btk inhibitors.Expert Opin Ther Pat. 2017 Dec;27(12):1305-1318. DMK4LOH RU https://www.ncbi.nlm.nih.gov/pubmed/28705083 DMZ4PLC DI DMZ4PLC DMZ4PLC DN Pyrrolo[2,3-d]pyrimidine derivative 15 DMZ4PLC MI TTGM6VW DMZ4PLC MN Tyrosine-protein kinase BTK (ATK) DMZ4PLC MT DTT DMZ4PLC MA Inhibitor DMZ4PLC RN Pyrrolo[2,3-d]pyrimidines active as Btk inhibitors.Expert Opin Ther Pat. 2017 Dec;27(12):1305-1318. DMZ4PLC RU https://www.ncbi.nlm.nih.gov/pubmed/28705083 DM1GYZQ DI DM1GYZQ DM1GYZQ DN Pyrrolo[2,3-d]pyrimidine derivative 16 DM1GYZQ MI TTGM6VW DM1GYZQ MN Tyrosine-protein kinase BTK (ATK) DM1GYZQ MT DTT DM1GYZQ MA Inhibitor DM1GYZQ RN Pyrrolo[2,3-d]pyrimidines active as Btk inhibitors.Expert Opin Ther Pat. 2017 Dec;27(12):1305-1318. DM1GYZQ RU https://www.ncbi.nlm.nih.gov/pubmed/28705083 DMXWVN2 DI DMXWVN2 DMXWVN2 DN Pyrrolo[2,3-d]pyrimidine derivative 17 DMXWVN2 MI TTGM6VW DMXWVN2 MN Tyrosine-protein kinase BTK (ATK) DMXWVN2 MT DTT DMXWVN2 MA Inhibitor DMXWVN2 RN Pyrrolo[2,3-d]pyrimidines active as Btk inhibitors.Expert Opin Ther Pat. 2017 Dec;27(12):1305-1318. DMXWVN2 RU https://www.ncbi.nlm.nih.gov/pubmed/28705083 DMSXH8K DI DMSXH8K DMSXH8K DN Pyrrolo[2,3-d]pyrimidine derivative 18 DMSXH8K MI TTGM6VW DMSXH8K MN Tyrosine-protein kinase BTK (ATK) DMSXH8K MT DTT DMSXH8K MA Inhibitor DMSXH8K RN Pyrrolo[2,3-d]pyrimidines active as Btk inhibitors.Expert Opin Ther Pat. 2017 Dec;27(12):1305-1318. DMSXH8K RU https://www.ncbi.nlm.nih.gov/pubmed/28705083 DMC9TGM DI DMC9TGM DMC9TGM DN Pyrrolo[2,3-d]pyrimidine derivative 19 DMC9TGM MI TTGM6VW DMC9TGM MN Tyrosine-protein kinase BTK (ATK) DMC9TGM MT DTT DMC9TGM MA Inhibitor DMC9TGM RN Pyrrolo[2,3-d]pyrimidines active as Btk inhibitors.Expert Opin Ther Pat. 2017 Dec;27(12):1305-1318. DMC9TGM RU https://www.ncbi.nlm.nih.gov/pubmed/28705083 DMJFYK1 DI DMJFYK1 DMJFYK1 DN Pyrrolo[2,3-d]pyrimidine derivative 2 DMJFYK1 MI TTIXKA4 DMJFYK1 MN Ribosomal protein S6 kinase alpha-1 (RSK1) DMJFYK1 MT DTT DMJFYK1 MA Inhibitor DMJFYK1 RN Ribosomal S6 kinase (RSK) modulators: a patent review.Expert Opin Ther Pat. 2016 Sep;26(9):1061-78. DMJFYK1 RU https://www.ncbi.nlm.nih.gov/pubmed/27410995 DM2E7DJ DI DM2E7DJ DM2E7DJ DN Pyrrolo[2,3-d]pyrimidine derivative 20 DM2E7DJ MI TTGM6VW DM2E7DJ MN Tyrosine-protein kinase BTK (ATK) DM2E7DJ MT DTT DM2E7DJ MA Inhibitor DM2E7DJ RN Pyrrolo[2,3-d]pyrimidines active as Btk inhibitors.Expert Opin Ther Pat. 2017 Dec;27(12):1305-1318. DM2E7DJ RU https://www.ncbi.nlm.nih.gov/pubmed/28705083 DM9S07A DI DM9S07A DM9S07A DN Pyrrolo[2,3-d]pyrimidine derivative 21 DM9S07A MI TTGM6VW DM9S07A MN Tyrosine-protein kinase BTK (ATK) DM9S07A MT DTT DM9S07A MA Inhibitor DM9S07A RN Pyrrolo[2,3-d]pyrimidines active as Btk inhibitors.Expert Opin Ther Pat. 2017 Dec;27(12):1305-1318. DM9S07A RU https://www.ncbi.nlm.nih.gov/pubmed/28705083 DMHWNSD DI DMHWNSD DMHWNSD DN Pyrrolo[2,3-d]pyrimidine derivative 22 DMHWNSD MI TTGM6VW DMHWNSD MN Tyrosine-protein kinase BTK (ATK) DMHWNSD MT DTT DMHWNSD MA Inhibitor DMHWNSD RN Pyrrolo[2,3-d]pyrimidines active as Btk inhibitors.Expert Opin Ther Pat. 2017 Dec;27(12):1305-1318. DMHWNSD RU https://www.ncbi.nlm.nih.gov/pubmed/28705083 DMTMWKX DI DMTMWKX DMTMWKX DN Pyrrolo[2,3-d]pyrimidine derivative 23 DMTMWKX MI TTGM6VW DMTMWKX MN Tyrosine-protein kinase BTK (ATK) DMTMWKX MT DTT DMTMWKX MA Inhibitor DMTMWKX RN Pyrrolo[2,3-d]pyrimidines active as Btk inhibitors.Expert Opin Ther Pat. 2017 Dec;27(12):1305-1318. DMTMWKX RU https://www.ncbi.nlm.nih.gov/pubmed/28705083 DMZQF9R DI DMZQF9R DMZQF9R DN Pyrrolo[2,3-d]pyrimidine derivative 24 DMZQF9R MI TTGKNB4 DMZQF9R MN Epidermal growth factor receptor (EGFR) DMZQF9R MT DTT DMZQF9R MA Inhibitor DMZQF9R RN Pyrrolo[2,3-d]pyrimidines active as Btk inhibitors.Expert Opin Ther Pat. 2017 Dec;27(12):1305-1318. DMZQF9R RU https://www.ncbi.nlm.nih.gov/pubmed/28705083 DMWU3O4 DI DMWU3O4 DMWU3O4 DN Pyrrolo[2,3-d]pyrimidine derivative 25 DMWU3O4 MI TTGM6VW DMWU3O4 MN Tyrosine-protein kinase BTK (ATK) DMWU3O4 MT DTT DMWU3O4 MA Inhibitor DMWU3O4 RN Pyrrolo[2,3-d]pyrimidines active as Btk inhibitors.Expert Opin Ther Pat. 2017 Dec;27(12):1305-1318. DMWU3O4 RU https://www.ncbi.nlm.nih.gov/pubmed/28705083 DMX1ANB DI DMX1ANB DMX1ANB DN Pyrrolo[2,3-d]pyrimidine derivative 26 DMX1ANB MI TTGM6VW DMX1ANB MN Tyrosine-protein kinase BTK (ATK) DMX1ANB MT DTT DMX1ANB MA Inhibitor DMX1ANB RN Pyrrolo[2,3-d]pyrimidines active as Btk inhibitors.Expert Opin Ther Pat. 2017 Dec;27(12):1305-1318. DMX1ANB RU https://www.ncbi.nlm.nih.gov/pubmed/28705083 DMCZJ1W DI DMCZJ1W DMCZJ1W DN Pyrrolo[2,3-d]pyrimidine derivative 27 DMCZJ1W MI TTGM6VW DMCZJ1W MN Tyrosine-protein kinase BTK (ATK) DMCZJ1W MT DTT DMCZJ1W MA Inhibitor DMCZJ1W RN Pyrrolo[2,3-d]pyrimidines active as Btk inhibitors.Expert Opin Ther Pat. 2017 Dec;27(12):1305-1318. DMCZJ1W RU https://www.ncbi.nlm.nih.gov/pubmed/28705083 DMXRJI2 DI DMXRJI2 DMXRJI2 DN Pyrrolo[2,3-d]pyrimidine derivative 28 DMXRJI2 MI TTGBPJE DMXRJI2 MN PI3-kinase delta (PIK3CD) DMXRJI2 MT DTT DMXRJI2 MA Inhibitor DMXRJI2 RN Pyrrolo[2,3-d]pyrimidines active as Btk inhibitors.Expert Opin Ther Pat. 2017 Dec;27(12):1305-1318. DMXRJI2 RU https://www.ncbi.nlm.nih.gov/pubmed/28705083 DMXRJI2 DI DMXRJI2 DMXRJI2 DN Pyrrolo[2,3-d]pyrimidine derivative 28 DMXRJI2 MI TTGM6VW DMXRJI2 MN Tyrosine-protein kinase BTK (ATK) DMXRJI2 MT DTT DMXRJI2 MA Inhibitor DMXRJI2 RN Pyrrolo[2,3-d]pyrimidines active as Btk inhibitors.Expert Opin Ther Pat. 2017 Dec;27(12):1305-1318. DMXRJI2 RU https://www.ncbi.nlm.nih.gov/pubmed/28705083 DM6IJRG DI DM6IJRG DM6IJRG DN Pyrrolo[2,3-d]pyrimidine derivative 29 DM6IJRG MI TTGM6VW DM6IJRG MN Tyrosine-protein kinase BTK (ATK) DM6IJRG MT DTT DM6IJRG MA Inhibitor DM6IJRG RN Pyrrolo[2,3-d]pyrimidines active as Btk inhibitors.Expert Opin Ther Pat. 2017 Dec;27(12):1305-1318. DM6IJRG RU https://www.ncbi.nlm.nih.gov/pubmed/28705083 DMTX1G4 DI DMTX1G4 DMTX1G4 DN Pyrrolo[2,3-d]pyrimidine derivative 3 DMTX1G4 MI TTTDVOJ DMTX1G4 MN Tropomyosin-related kinase A (TrkA) DMTX1G4 MT DTT DMTX1G4 MA Inhibitor DMTX1G4 RN Tropomyosin receptor kinase inhibitors: an updated patent review for 2010-2016 - Part II.Expert Opin Ther Pat. 2017 Jul;27(7):831-849. DMTX1G4 RU https://www.ncbi.nlm.nih.gov/pubmed/28270021 DM57W29 DI DM57W29 DM57W29 DN Pyrrolo[2,3-d]pyrimidine derivative 30 DM57W29 MI TTGM6VW DM57W29 MN Tyrosine-protein kinase BTK (ATK) DM57W29 MT DTT DM57W29 MA Inhibitor DM57W29 RN Pyrrolo[2,3-d]pyrimidines active as Btk inhibitors.Expert Opin Ther Pat. 2017 Dec;27(12):1305-1318. DM57W29 RU https://www.ncbi.nlm.nih.gov/pubmed/28705083 DMA9PM4 DI DMA9PM4 DMA9PM4 DN Pyrrolo[2,3-d]pyrimidine derivative 31 DMA9PM4 MI TTGM6VW DMA9PM4 MN Tyrosine-protein kinase BTK (ATK) DMA9PM4 MT DTT DMA9PM4 MA Inhibitor DMA9PM4 RN Pyrrolo[2,3-d]pyrimidines active as Btk inhibitors.Expert Opin Ther Pat. 2017 Dec;27(12):1305-1318. DMA9PM4 RU https://www.ncbi.nlm.nih.gov/pubmed/28705083 DMQGI0R DI DMQGI0R DMQGI0R DN Pyrrolo[2,3-d]pyrimidine derivative 32 DMQGI0R MI TTGM6VW DMQGI0R MN Tyrosine-protein kinase BTK (ATK) DMQGI0R MT DTT DMQGI0R MA Inhibitor DMQGI0R RN Pyrrolo[2,3-d]pyrimidines active as Btk inhibitors.Expert Opin Ther Pat. 2017 Dec;27(12):1305-1318. DMQGI0R RU https://www.ncbi.nlm.nih.gov/pubmed/28705083 DM6BTMX DI DM6BTMX DM6BTMX DN Pyrrolo[2,3-d]pyrimidine derivative 33 DM6BTMX MI TTGM6VW DM6BTMX MN Tyrosine-protein kinase BTK (ATK) DM6BTMX MT DTT DM6BTMX MA Inhibitor DM6BTMX RN Pyrrolo[2,3-d]pyrimidines active as Btk inhibitors.Expert Opin Ther Pat. 2017 Dec;27(12):1305-1318. DM6BTMX RU https://www.ncbi.nlm.nih.gov/pubmed/28705083 DMXU08A DI DMXU08A DMXU08A DN Pyrrolo[2,3-d]pyrimidine derivative 35 DMXU08A MI TTUM2ZR DMXU08A MN Ribosomal protein S6 kinase alpha-3 (RSK3) DMXU08A MT DTT DMXU08A MA Inhibitor DMXU08A RN Ribosomal S6 kinase (RSK) modulators: a patent review.Expert Opin Ther Pat. 2016 Sep;26(9):1061-78. DMXU08A RU https://www.ncbi.nlm.nih.gov/pubmed/27410995 DME0WSR DI DME0WSR DME0WSR DN Pyrrolo[2,3-d]pyrimidine derivative 4 DME0WSR MI TTKN7QR DME0WSR MN BDNF/NT-3 growth factors receptor (TrkB) DME0WSR MT DTT DME0WSR MA Inhibitor DME0WSR RN Tropomyosin receptor kinase inhibitors: an updated patent review for 2010-2016 - Part II.Expert Opin Ther Pat. 2017 Jul;27(7):831-849. DME0WSR RU https://www.ncbi.nlm.nih.gov/pubmed/28270021 DME0WSR DI DME0WSR DME0WSR DN Pyrrolo[2,3-d]pyrimidine derivative 4 DME0WSR MI TTXABCW DME0WSR MN NT-3 growth factor receptor (TrkC) DME0WSR MT DTT DME0WSR MA Inhibitor DME0WSR RN Tropomyosin receptor kinase inhibitors: an updated patent review for 2010-2016 - Part II.Expert Opin Ther Pat. 2017 Jul;27(7):831-849. DME0WSR RU https://www.ncbi.nlm.nih.gov/pubmed/28270021 DME0WSR DI DME0WSR DME0WSR DN Pyrrolo[2,3-d]pyrimidine derivative 4 DME0WSR MI TTTDVOJ DME0WSR MN Tropomyosin-related kinase A (TrkA) DME0WSR MT DTT DME0WSR MA Inhibitor DME0WSR RN Tropomyosin receptor kinase inhibitors: an updated patent review for 2010-2016 - Part II.Expert Opin Ther Pat. 2017 Jul;27(7):831-849. DME0WSR RU https://www.ncbi.nlm.nih.gov/pubmed/28270021 DM3D1L6 DI DM3D1L6 DM3D1L6 DN Pyrrolo[2,3-d]pyrimidine derivative 6 DM3D1L6 MI TT6DM01 DM3D1L6 MN Janus kinase 1 (JAK-1) DM3D1L6 MT DTT DM3D1L6 MA Inhibitor DM3D1L6 RN Inhibitors of JAK-family kinases: an update on the patent literature 2013-2015, part 2.Expert Opin Ther Pat. 2017 Feb;27(2):145-161. DM3D1L6 RU https://www.ncbi.nlm.nih.gov/pubmed/27774822 DM3D1L6 DI DM3D1L6 DM3D1L6 DN Pyrrolo[2,3-d]pyrimidine derivative 6 DM3D1L6 MI TTRMX3V DM3D1L6 MN Janus kinase 2 (JAK-2) DM3D1L6 MT DTT DM3D1L6 MA Inhibitor DM3D1L6 RN Inhibitors of JAK-family kinases: an update on the patent literature 2013-2015, part 2.Expert Opin Ther Pat. 2017 Feb;27(2):145-161. DM3D1L6 RU https://www.ncbi.nlm.nih.gov/pubmed/27774822 DM3D1L6 DI DM3D1L6 DM3D1L6 DN Pyrrolo[2,3-d]pyrimidine derivative 6 DM3D1L6 MI TTT7PJU DM3D1L6 MN Janus kinase 3 (JAK-3) DM3D1L6 MT DTT DM3D1L6 MA Inhibitor DM3D1L6 RN Inhibitors of JAK-family kinases: an update on the patent literature 2013-2015, part 2.Expert Opin Ther Pat. 2017 Feb;27(2):145-161. DM3D1L6 RU https://www.ncbi.nlm.nih.gov/pubmed/27774822 DM3D1L6 DI DM3D1L6 DM3D1L6 DN Pyrrolo[2,3-d]pyrimidine derivative 6 DM3D1L6 MI TTBYWP2 DM3D1L6 MN TYK2 tyrosine kinase (TYK2) DM3D1L6 MT DTT DM3D1L6 MA Inhibitor DM3D1L6 RN Inhibitors of JAK-family kinases: an update on the patent literature 2013-2015, part 2.Expert Opin Ther Pat. 2017 Feb;27(2):145-161. DM3D1L6 RU https://www.ncbi.nlm.nih.gov/pubmed/27774822 DM30Y8M DI DM30Y8M DM30Y8M DN Pyrrolo[2,3-d]pyrimidine derivative 7 DM30Y8M MI TT6DM01 DM30Y8M MN Janus kinase 1 (JAK-1) DM30Y8M MT DTT DM30Y8M MA Inhibitor DM30Y8M RN Inhibitors of JAK-family kinases: an update on the patent literature 2013-2015, part 2.Expert Opin Ther Pat. 2017 Feb;27(2):145-161. DM30Y8M RU https://www.ncbi.nlm.nih.gov/pubmed/27774822 DM30Y8M DI DM30Y8M DM30Y8M DN Pyrrolo[2,3-d]pyrimidine derivative 7 DM30Y8M MI TTRMX3V DM30Y8M MN Janus kinase 2 (JAK-2) DM30Y8M MT DTT DM30Y8M MA Inhibitor DM30Y8M RN Inhibitors of JAK-family kinases: an update on the patent literature 2013-2015, part 2.Expert Opin Ther Pat. 2017 Feb;27(2):145-161. DM30Y8M RU https://www.ncbi.nlm.nih.gov/pubmed/27774822 DM30Y8M DI DM30Y8M DM30Y8M DN Pyrrolo[2,3-d]pyrimidine derivative 7 DM30Y8M MI TTT7PJU DM30Y8M MN Janus kinase 3 (JAK-3) DM30Y8M MT DTT DM30Y8M MA Inhibitor DM30Y8M RN Inhibitors of JAK-family kinases: an update on the patent literature 2013-2015, part 2.Expert Opin Ther Pat. 2017 Feb;27(2):145-161. DM30Y8M RU https://www.ncbi.nlm.nih.gov/pubmed/27774822 DM30Y8M DI DM30Y8M DM30Y8M DN Pyrrolo[2,3-d]pyrimidine derivative 7 DM30Y8M MI TTBYWP2 DM30Y8M MN TYK2 tyrosine kinase (TYK2) DM30Y8M MT DTT DM30Y8M MA Inhibitor DM30Y8M RN Inhibitors of JAK-family kinases: an update on the patent literature 2013-2015, part 2.Expert Opin Ther Pat. 2017 Feb;27(2):145-161. DM30Y8M RU https://www.ncbi.nlm.nih.gov/pubmed/27774822 DMAW6KU DI DMAW6KU DMAW6KU DN Pyrrolo[2,3-d]pyrimidine derivative 8 DMAW6KU MI TT6DM01 DMAW6KU MN Janus kinase 1 (JAK-1) DMAW6KU MT DTT DMAW6KU MA Inhibitor DMAW6KU RN Inhibitors of JAK-family kinases: an update on the patent literature 2013-2015, part 2.Expert Opin Ther Pat. 2017 Feb;27(2):145-161. DMAW6KU RU https://www.ncbi.nlm.nih.gov/pubmed/27774822 DMAW6KU DI DMAW6KU DMAW6KU DN Pyrrolo[2,3-d]pyrimidine derivative 8 DMAW6KU MI TTRMX3V DMAW6KU MN Janus kinase 2 (JAK-2) DMAW6KU MT DTT DMAW6KU MA Inhibitor DMAW6KU RN Inhibitors of JAK-family kinases: an update on the patent literature 2013-2015, part 2.Expert Opin Ther Pat. 2017 Feb;27(2):145-161. DMAW6KU RU https://www.ncbi.nlm.nih.gov/pubmed/27774822 DMAW6KU DI DMAW6KU DMAW6KU DN Pyrrolo[2,3-d]pyrimidine derivative 8 DMAW6KU MI TTT7PJU DMAW6KU MN Janus kinase 3 (JAK-3) DMAW6KU MT DTT DMAW6KU MA Inhibitor DMAW6KU RN Inhibitors of JAK-family kinases: an update on the patent literature 2013-2015, part 2.Expert Opin Ther Pat. 2017 Feb;27(2):145-161. DMAW6KU RU https://www.ncbi.nlm.nih.gov/pubmed/27774822 DMAW6KU DI DMAW6KU DMAW6KU DN Pyrrolo[2,3-d]pyrimidine derivative 8 DMAW6KU MI TTBYWP2 DMAW6KU MN TYK2 tyrosine kinase (TYK2) DMAW6KU MT DTT DMAW6KU MA Inhibitor DMAW6KU RN Inhibitors of JAK-family kinases: an update on the patent literature 2013-2015, part 2.Expert Opin Ther Pat. 2017 Feb;27(2):145-161. DMAW6KU RU https://www.ncbi.nlm.nih.gov/pubmed/27774822 DM0HU5O DI DM0HU5O DM0HU5O DN Pyrrolo[2,3-d]pyrimidine derivative 9 DM0HU5O MI TTH6V3D DM0HU5O MN Cyclin-dependent kinase 1 (CDK1) DM0HU5O MT DTT DM0HU5O MA Inhibitor DM0HU5O RN Cyclin-dependent kinase inhibitors for cancer therapy: a patent review (2009 - 2014).Expert Opin Ther Pat. 2015;25(9):953-70. DM0HU5O RU https://www.ncbi.nlm.nih.gov/pubmed/26161698 DM0HU5O DI DM0HU5O DM0HU5O DN Pyrrolo[2,3-d]pyrimidine derivative 9 DM0HU5O MI TT7HF4W DM0HU5O MN Cyclin-dependent kinase 2 (CDK2) DM0HU5O MT DTT DM0HU5O MA Inhibitor DM0HU5O RN Cyclin-dependent kinase inhibitors for cancer therapy: a patent review (2009 - 2014).Expert Opin Ther Pat. 2015;25(9):953-70. DM0HU5O RU https://www.ncbi.nlm.nih.gov/pubmed/26161698 DM0HU5O DI DM0HU5O DM0HU5O DN Pyrrolo[2,3-d]pyrimidine derivative 9 DM0HU5O MI TT0PG8F DM0HU5O MN Cyclin-dependent kinase 4 (CDK4) DM0HU5O MT DTT DM0HU5O MA Inhibitor DM0HU5O RN Cyclin-dependent kinase inhibitors for cancer therapy: a patent review (2009 - 2014).Expert Opin Ther Pat. 2015;25(9):953-70. DM0HU5O RU https://www.ncbi.nlm.nih.gov/pubmed/26161698 DMKF8HI DI DMKF8HI DMKF8HI DN Pyrrolo[3,2-c]pyridine derivative 1 DMKF8HI MI TTTDVOJ DMKF8HI MN Tropomyosin-related kinase A (TrkA) DMKF8HI MT DTT DMKF8HI MA Inhibitor DMKF8HI RN Tropomyosin receptor kinase inhibitors: an updated patent review for 2010-2016 - Part II.Expert Opin Ther Pat. 2017 Jul;27(7):831-849. DMKF8HI RU https://www.ncbi.nlm.nih.gov/pubmed/28270021 DMS4I6B DI DMS4I6B DMS4I6B DN Pyrrolo-benzo-diazine derivative 1 DMS4I6B MI TT4G2JS DMS4I6B MN Voltage-gated sodium channel alpha Nav1.7 (SCN9A) DMS4I6B MT DTT DMS4I6B MA Blocker DMS4I6B RN Sodium channel blockers: a patent review (2010 - 2014).Expert Opin Ther Pat. 2015 Mar;25(3):279-90. DMS4I6B RU https://www.ncbi.nlm.nih.gov/pubmed/25539043 DMP8I02 DI DMP8I02 DMP8I02 DN Pyrrolo-pyrazine derivative 1 DMP8I02 MI TTT7PJU DMP8I02 MN Janus kinase 3 (JAK-3) DMP8I02 MT DTT DMP8I02 MA Inhibitor DMP8I02 RN Inhibitors of JAK-family kinases: an update on the patent literature 2013-2015, part 2.Expert Opin Ther Pat. 2017 Feb;27(2):145-161. DMP8I02 RU https://www.ncbi.nlm.nih.gov/pubmed/27774822 DMO9Q8J DI DMO9Q8J DMO9Q8J DN Pyrrolo-pyrazine derivative 2 DMO9Q8J MI TTT7PJU DMO9Q8J MN Janus kinase 3 (JAK-3) DMO9Q8J MT DTT DMO9Q8J MA Inhibitor DMO9Q8J RN Inhibitors of JAK-family kinases: an update on the patent literature 2013-2015, part 2.Expert Opin Ther Pat. 2017 Feb;27(2):145-161. DMO9Q8J RU https://www.ncbi.nlm.nih.gov/pubmed/27774822 DMLM6DT DI DMLM6DT DMLM6DT DN Pyrrolo-pyrazine derivative 3 DMLM6DT MI TTT7PJU DMLM6DT MN Janus kinase 3 (JAK-3) DMLM6DT MT DTT DMLM6DT MA Inhibitor DMLM6DT RN Inhibitors of JAK-family kinases: an update on the patent literature 2013-2015, part 2.Expert Opin Ther Pat. 2017 Feb;27(2):145-161. DMLM6DT RU https://www.ncbi.nlm.nih.gov/pubmed/27774822 DMLM6DT DI DMLM6DT DMLM6DT DN Pyrrolo-pyrazine derivative 3 DMLM6DT MI TTOU65C DMLM6DT MN Tyrosine-protein kinase SYK (SYK) DMLM6DT MT DTT DMLM6DT MA Inhibitor DMLM6DT RN Inhibitors of JAK-family kinases: an update on the patent literature 2013-2015, part 2.Expert Opin Ther Pat. 2017 Feb;27(2):145-161. DMLM6DT RU https://www.ncbi.nlm.nih.gov/pubmed/27774822 DMD1S92 DI DMD1S92 DMD1S92 DN Pyrrolo-pyrazine derivative 4 DMD1S92 MI TTT7PJU DMD1S92 MN Janus kinase 3 (JAK-3) DMD1S92 MT DTT DMD1S92 MA Inhibitor DMD1S92 RN Inhibitors of JAK-family kinases: an update on the patent literature 2013-2015, part 2.Expert Opin Ther Pat. 2017 Feb;27(2):145-161. DMD1S92 RU https://www.ncbi.nlm.nih.gov/pubmed/27774822 DMD1S92 DI DMD1S92 DMD1S92 DN Pyrrolo-pyrazine derivative 4 DMD1S92 MI TTOU65C DMD1S92 MN Tyrosine-protein kinase SYK (SYK) DMD1S92 MT DTT DMD1S92 MA Inhibitor DMD1S92 RN Inhibitors of JAK-family kinases: an update on the patent literature 2013-2015, part 2.Expert Opin Ther Pat. 2017 Feb;27(2):145-161. DMD1S92 RU https://www.ncbi.nlm.nih.gov/pubmed/27774822 DMQ2U54 DI DMQ2U54 DMQ2U54 DN Pyrrolo-pyridazine derivative 1 DMQ2U54 MI TTK0FEA DMQ2U54 MN Leucine-rich repeat kinase 2 (LRRK2) DMQ2U54 MT DTT DMQ2U54 MA Inhibitor DMQ2U54 RN Leucine-rich repeat kinase 2 inhibitors: a patent review (2014-2016).Expert Opin Ther Pat. 2017 Jun;27(6):667-676. DMQ2U54 RU https://www.ncbi.nlm.nih.gov/pubmed/28117607 DM9K5CI DI DM9K5CI DM9K5CI DN Pyrrolo-pyridine derivative 1 DM9K5CI MI TTK0FEA DM9K5CI MN Leucine-rich repeat kinase 2 (LRRK2) DM9K5CI MT DTT DM9K5CI MA Inhibitor DM9K5CI RN Leucine-rich repeat kinase 2 inhibitors: a patent review (2014-2016).Expert Opin Ther Pat. 2017 Jun;27(6):667-676. DM9K5CI RU https://www.ncbi.nlm.nih.gov/pubmed/28117607 DMVNY5I DI DMVNY5I DMVNY5I DN Pyrrolo-pyridine derivative 2 DMVNY5I MI TTK0FEA DMVNY5I MN Leucine-rich repeat kinase 2 (LRRK2) DMVNY5I MT DTT DMVNY5I MA Inhibitor DMVNY5I RN Leucine-rich repeat kinase 2 inhibitors: a patent review (2014-2016).Expert Opin Ther Pat. 2017 Jun;27(6):667-676. DMVNY5I RU https://www.ncbi.nlm.nih.gov/pubmed/28117607 DMVNY5I DI DMVNY5I DMVNY5I DN Pyrrolo-pyridine derivative 2 DMVNY5I MI TT6AXLY DMVNY5I MN Leucine-rich repeat kinase 2 G2019S mutant (LRRK2 G2019S) DMVNY5I MT DTT DMVNY5I MA Inhibitor DMVNY5I RN Leucine-rich repeat kinase 2 inhibitors: a patent review (2014-2016).Expert Opin Ther Pat. 2017 Jun;27(6):667-676. DMVNY5I RU https://www.ncbi.nlm.nih.gov/pubmed/28117607 DMSNQEJ DI DMSNQEJ DMSNQEJ DN Pyrrolo-pyridine derivative 3 DMSNQEJ MI TT6DM01 DMSNQEJ MN Janus kinase 1 (JAK-1) DMSNQEJ MT DTT DMSNQEJ MA Inhibitor DMSNQEJ RN Inhibitors of JAK-family kinases: an update on the patent literature 2013-2015, part 2.Expert Opin Ther Pat. 2017 Feb;27(2):145-161. DMSNQEJ RU https://www.ncbi.nlm.nih.gov/pubmed/27774822 DMSNQEJ DI DMSNQEJ DMSNQEJ DN Pyrrolo-pyridine derivative 3 DMSNQEJ MI TTRMX3V DMSNQEJ MN Janus kinase 2 (JAK-2) DMSNQEJ MT DTT DMSNQEJ MA Inhibitor DMSNQEJ RN Inhibitors of JAK-family kinases: an update on the patent literature 2013-2015, part 2.Expert Opin Ther Pat. 2017 Feb;27(2):145-161. DMSNQEJ RU https://www.ncbi.nlm.nih.gov/pubmed/27774822 DMSNQEJ DI DMSNQEJ DMSNQEJ DN Pyrrolo-pyridine derivative 3 DMSNQEJ MI TTT7PJU DMSNQEJ MN Janus kinase 3 (JAK-3) DMSNQEJ MT DTT DMSNQEJ MA Inhibitor DMSNQEJ RN Inhibitors of JAK-family kinases: an update on the patent literature 2013-2015, part 2.Expert Opin Ther Pat. 2017 Feb;27(2):145-161. DMSNQEJ RU https://www.ncbi.nlm.nih.gov/pubmed/27774822 DMK820T DI DMK820T DMK820T DN Pyrrolo-pyridinone derivative 1 DMK820T MI TT4DXQT DMK820T MN Proto-oncogene c-Ret (RET) DMK820T MT DTT DMK820T MA Inhibitor DMK820T RN RET kinase inhibitors: a review of recent patents (2012-2015).Expert Opin Ther Pat. 2017 Jan;27(1):91-99. DMK820T RU https://www.ncbi.nlm.nih.gov/pubmed/27646564 DM5G67X DI DM5G67X DM5G67X DN Pyrrolo-pyridinone derivative 2 DM5G67X MI TT4DXQT DM5G67X MN Proto-oncogene c-Ret (RET) DM5G67X MT DTT DM5G67X MA Inhibitor DM5G67X RN RET kinase inhibitors: a review of recent patents (2012-2015).Expert Opin Ther Pat. 2017 Jan;27(1):91-99. DM5G67X RU https://www.ncbi.nlm.nih.gov/pubmed/27646564 DME1Q3W DI DME1Q3W DME1Q3W DN Pyrrolo-pyridinone derivative 3 DME1Q3W MI TT4DXQT DME1Q3W MN Proto-oncogene c-Ret (RET) DME1Q3W MT DTT DME1Q3W MA Inhibitor DME1Q3W RN RET kinase inhibitors: a review of recent patents (2012-2015).Expert Opin Ther Pat. 2017 Jan;27(1):91-99. DME1Q3W RU https://www.ncbi.nlm.nih.gov/pubmed/27646564 DM2EVJR DI DM2EVJR DM2EVJR DN Pyrrolo-pyridinone derivative 4 DM2EVJR MI TT4DXQT DM2EVJR MN Proto-oncogene c-Ret (RET) DM2EVJR MT DTT DM2EVJR MA Inhibitor DM2EVJR RN RET kinase inhibitors: a review of recent patents (2012-2015).Expert Opin Ther Pat. 2017 Jan;27(1):91-99. DM2EVJR RU https://www.ncbi.nlm.nih.gov/pubmed/27646564 DMK2FSY DI DMK2FSY DMK2FSY DN Pyrrolo-pyridinone derivative 5 DMK2FSY MI TTAXZ0K DMK2FSY MN Voltage-gated sodium channel alpha Nav1.3 (SCN3A) DMK2FSY MT DTT DMK2FSY MA Inhibitor DMK2FSY RN Sodium channel blockers: a patent review (2010 - 2014).Expert Opin Ther Pat. 2015 Mar;25(3):279-90. DMK2FSY RU https://www.ncbi.nlm.nih.gov/pubmed/25539043 DMK2FSY DI DMK2FSY DMK2FSY DN Pyrrolo-pyridinone derivative 5 DMK2FSY MI TT4G2JS DMK2FSY MN Voltage-gated sodium channel alpha Nav1.7 (SCN9A) DMK2FSY MT DTT DMK2FSY MA Inhibitor DMK2FSY RN Sodium channel blockers: a patent review (2010 - 2014).Expert Opin Ther Pat. 2015 Mar;25(3):279-90. DMK2FSY RU https://www.ncbi.nlm.nih.gov/pubmed/25539043 DMXGNP8 DI DMXGNP8 DMXGNP8 DN Pyrrolo-pyridinone derivative 6 DMXGNP8 MI TTAXZ0K DMXGNP8 MN Voltage-gated sodium channel alpha Nav1.3 (SCN3A) DMXGNP8 MT DTT DMXGNP8 MA Inhibitor DMXGNP8 RN Sodium channel blockers: a patent review (2010 - 2014).Expert Opin Ther Pat. 2015 Mar;25(3):279-90. DMXGNP8 RU https://www.ncbi.nlm.nih.gov/pubmed/25539043 DMXGNP8 DI DMXGNP8 DMXGNP8 DN Pyrrolo-pyridinone derivative 6 DMXGNP8 MI TT4G2JS DMXGNP8 MN Voltage-gated sodium channel alpha Nav1.7 (SCN9A) DMXGNP8 MT DTT DMXGNP8 MA Inhibitor DMXGNP8 RN Sodium channel blockers: a patent review (2010 - 2014).Expert Opin Ther Pat. 2015 Mar;25(3):279-90. DMXGNP8 RU https://www.ncbi.nlm.nih.gov/pubmed/25539043 DMR6QCE DI DMR6QCE DMR6QCE DN Pyrrolo-pyridone derivative 1 DMR6QCE MI TT6DM01 DMR6QCE MN Janus kinase 1 (JAK-1) DMR6QCE MT DTT DMR6QCE MA Inhibitor DMR6QCE RN Inhibitors of JAK-family kinases: an update on the patent literature 2013-2015, part 2.Expert Opin Ther Pat. 2017 Feb;27(2):145-161. DMR6QCE RU https://www.ncbi.nlm.nih.gov/pubmed/27774822 DMR6QCE DI DMR6QCE DMR6QCE DN Pyrrolo-pyridone derivative 1 DMR6QCE MI TTRMX3V DMR6QCE MN Janus kinase 2 (JAK-2) DMR6QCE MT DTT DMR6QCE MA Inhibitor DMR6QCE RN Inhibitors of JAK-family kinases: an update on the patent literature 2013-2015, part 2.Expert Opin Ther Pat. 2017 Feb;27(2):145-161. DMR6QCE RU https://www.ncbi.nlm.nih.gov/pubmed/27774822 DMCZ8UV DI DMCZ8UV DMCZ8UV DN Pyrrolo-pyridone derivative 2 DMCZ8UV MI TT6DM01 DMCZ8UV MN Janus kinase 1 (JAK-1) DMCZ8UV MT DTT DMCZ8UV MA Inhibitor DMCZ8UV RN Inhibitors of JAK-family kinases: an update on the patent literature 2013-2015, part 2.Expert Opin Ther Pat. 2017 Feb;27(2):145-161. DMCZ8UV RU https://www.ncbi.nlm.nih.gov/pubmed/27774822 DMCZ8UV DI DMCZ8UV DMCZ8UV DN Pyrrolo-pyridone derivative 2 DMCZ8UV MI TTRMX3V DMCZ8UV MN Janus kinase 2 (JAK-2) DMCZ8UV MT DTT DMCZ8UV MA Inhibitor DMCZ8UV RN Inhibitors of JAK-family kinases: an update on the patent literature 2013-2015, part 2.Expert Opin Ther Pat. 2017 Feb;27(2):145-161. DMCZ8UV RU https://www.ncbi.nlm.nih.gov/pubmed/27774822 DMUIK3W DI DMUIK3W DMUIK3W DN Pyrrolo-pyridone derivative 3 DMUIK3W MI TT6DM01 DMUIK3W MN Janus kinase 1 (JAK-1) DMUIK3W MT DTT DMUIK3W MA Inhibitor DMUIK3W RN Inhibitors of JAK-family kinases: an update on the patent literature 2013-2015, part 2.Expert Opin Ther Pat. 2017 Feb;27(2):145-161. DMUIK3W RU https://www.ncbi.nlm.nih.gov/pubmed/27774822 DMUIK3W DI DMUIK3W DMUIK3W DN Pyrrolo-pyridone derivative 3 DMUIK3W MI TTBYWP2 DMUIK3W MN TYK2 tyrosine kinase (TYK2) DMUIK3W MT DTT DMUIK3W MA Inhibitor DMUIK3W RN Inhibitors of JAK-family kinases: an update on the patent literature 2013-2015, part 2.Expert Opin Ther Pat. 2017 Feb;27(2):145-161. DMUIK3W RU https://www.ncbi.nlm.nih.gov/pubmed/27774822 DMEVXT0 DI DMEVXT0 DMEVXT0 DN Pyrrolo-pyrimidine derivative 1 DMEVXT0 MI TTK0FEA DMEVXT0 MN Leucine-rich repeat kinase 2 (LRRK2) DMEVXT0 MT DTT DMEVXT0 MA Inhibitor DMEVXT0 RN Leucine-rich repeat kinase 2 inhibitors: a patent review (2014-2016).Expert Opin Ther Pat. 2017 Jun;27(6):667-676. DMEVXT0 RU https://www.ncbi.nlm.nih.gov/pubmed/28117607 DMR0ZU6 DI DMR0ZU6 DMR0ZU6 DN Pyrrolo-pyrimidine derivative 10 DMR0ZU6 MI TTK0FEA DMR0ZU6 MN Leucine-rich repeat kinase 2 (LRRK2) DMR0ZU6 MT DTT DMR0ZU6 MA Inhibitor DMR0ZU6 RN Leucine-rich repeat kinase 2 inhibitors: a patent review (2014-2016).Expert Opin Ther Pat. 2017 Jun;27(6):667-676. DMR0ZU6 RU https://www.ncbi.nlm.nih.gov/pubmed/28117607 DMEIDC0 DI DMEIDC0 DMEIDC0 DN Pyrrolo-pyrimidine derivative 11 DMEIDC0 MI TTK0FEA DMEIDC0 MN Leucine-rich repeat kinase 2 (LRRK2) DMEIDC0 MT DTT DMEIDC0 MA Inhibitor DMEIDC0 RN Leucine-rich repeat kinase 2 inhibitors: a patent review (2014-2016).Expert Opin Ther Pat. 2017 Jun;27(6):667-676. DMEIDC0 RU https://www.ncbi.nlm.nih.gov/pubmed/28117607 DMEHYBJ DI DMEHYBJ DMEHYBJ DN Pyrrolo-pyrimidine derivative 2 DMEHYBJ MI TT4DXQT DMEHYBJ MN Proto-oncogene c-Ret (RET) DMEHYBJ MT DTT DMEHYBJ MA Inhibitor DMEHYBJ RN RET kinase inhibitors: a review of recent patents (2012-2015).Expert Opin Ther Pat. 2017 Jan;27(1):91-99. DMEHYBJ RU https://www.ncbi.nlm.nih.gov/pubmed/27646564 DMKHWN9 DI DMKHWN9 DMKHWN9 DN Pyrrolo-pyrimidine derivative 3 DMKHWN9 MI TT4DXQT DMKHWN9 MN Proto-oncogene c-Ret (RET) DMKHWN9 MT DTT DMKHWN9 MA Inhibitor DMKHWN9 RN RET kinase inhibitors: a review of recent patents (2012-2015).Expert Opin Ther Pat. 2017 Jan;27(1):91-99. DMKHWN9 RU https://www.ncbi.nlm.nih.gov/pubmed/27646564 DMITK03 DI DMITK03 DMITK03 DN Pyrrolo-pyrimidine derivative 4 DMITK03 MI TT4DXQT DMITK03 MN Proto-oncogene c-Ret (RET) DMITK03 MT DTT DMITK03 MA Inhibitor DMITK03 RN RET kinase inhibitors: a review of recent patents (2012-2015).Expert Opin Ther Pat. 2017 Jan;27(1):91-99. DMITK03 RU https://www.ncbi.nlm.nih.gov/pubmed/27646564 DMVA95G DI DMVA95G DMVA95G DN Pyrrolo-pyrimidine derivative 5 DMVA95G MI TT4DXQT DMVA95G MN Proto-oncogene c-Ret (RET) DMVA95G MT DTT DMVA95G MA Inhibitor DMVA95G RN RET kinase inhibitors: a review of recent patents (2012-2015).Expert Opin Ther Pat. 2017 Jan;27(1):91-99. DMVA95G RU https://www.ncbi.nlm.nih.gov/pubmed/27646564 DMGYT81 DI DMGYT81 DMGYT81 DN Pyrrolo-pyrimidine derivative 6 DMGYT81 MI TT4DXQT DMGYT81 MN Proto-oncogene c-Ret (RET) DMGYT81 MT DTT DMGYT81 MA Inhibitor DMGYT81 RN RET kinase inhibitors: a review of recent patents (2012-2015).Expert Opin Ther Pat. 2017 Jan;27(1):91-99. DMGYT81 RU https://www.ncbi.nlm.nih.gov/pubmed/27646564 DMZH27I DI DMZH27I DMZH27I DN Pyrrolo-pyrimidine derivative 8 DMZH27I MI TTK0FEA DMZH27I MN Leucine-rich repeat kinase 2 (LRRK2) DMZH27I MT DTT DMZH27I MA Inhibitor DMZH27I RN Leucine-rich repeat kinase 2 inhibitors: a patent review (2014-2016).Expert Opin Ther Pat. 2017 Jun;27(6):667-676. DMZH27I RU https://www.ncbi.nlm.nih.gov/pubmed/28117607 DMJEV86 DI DMJEV86 DMJEV86 DN Pyrrolo-pyrimidine derivative 9 DMJEV86 MI TTK0FEA DMJEV86 MN Leucine-rich repeat kinase 2 (LRRK2) DMJEV86 MT DTT DMJEV86 MA Inhibitor DMJEV86 RN Leucine-rich repeat kinase 2 inhibitors: a patent review (2014-2016).Expert Opin Ther Pat. 2017 Jun;27(6):667-676. DMJEV86 RU https://www.ncbi.nlm.nih.gov/pubmed/28117607 DMN4SE5 DI DMN4SE5 DMN4SE5 DN Pyrrolo-pyrrolone derivative 1 DMN4SE5 MI TTDP48B DMN4SE5 MN Bromodomain-containing protein 2 (BRD2) DMN4SE5 MT DTT DMN4SE5 MA Inhibitor DMN4SE5 RN BET inhibitors in cancer therapeutics: a patent review.Expert Opin Ther Pat. 2016;26(4):505-22. DMN4SE5 RU https://www.ncbi.nlm.nih.gov/pubmed/26924192 DMN4SE5 DI DMN4SE5 DMN4SE5 DN Pyrrolo-pyrrolone derivative 1 DMN4SE5 MI TTHE657 DMN4SE5 MN Bromodomain-containing protein 3 (BRD3) DMN4SE5 MT DTT DMN4SE5 MA Inhibitor DMN4SE5 RN BET inhibitors in cancer therapeutics: a patent review.Expert Opin Ther Pat. 2016;26(4):505-22. DMN4SE5 RU https://www.ncbi.nlm.nih.gov/pubmed/26924192 DMN4SE5 DI DMN4SE5 DMN4SE5 DN Pyrrolo-pyrrolone derivative 1 DMN4SE5 MI TTRA6BO DMN4SE5 MN Bromodomain-containing protein 4 (BRD4) DMN4SE5 MT DTT DMN4SE5 MA Inhibitor DMN4SE5 RN BET inhibitors in cancer therapeutics: a patent review.Expert Opin Ther Pat. 2016;26(4):505-22. DMN4SE5 RU https://www.ncbi.nlm.nih.gov/pubmed/26924192 DM8VYMA DI DM8VYMA DM8VYMA DN Pyrrolo-pyrrolone derivative 2 DM8VYMA MI TTRA6BO DM8VYMA MN Bromodomain-containing protein 4 (BRD4) DM8VYMA MT DTT DM8VYMA MA Inhibitor DM8VYMA RN BET inhibitors in cancer therapeutics: a patent review.Expert Opin Ther Pat. 2016;26(4):505-22. DM8VYMA RU https://www.ncbi.nlm.nih.gov/pubmed/26924192 DMHGPU1 DI DMHGPU1 DMHGPU1 DN Pyrrolo-pyrrolone derivative 3 DMHGPU1 MI TTRA6BO DMHGPU1 MN Bromodomain-containing protein 4 (BRD4) DMHGPU1 MT DTT DMHGPU1 MA Inhibitor DMHGPU1 RN BET inhibitors in cancer therapeutics: a patent review.Expert Opin Ther Pat. 2016;26(4):505-22. DMHGPU1 RU https://www.ncbi.nlm.nih.gov/pubmed/26924192 DMFJBZI DI DMFJBZI DMFJBZI DN Pyrrolo-pyrrolone derivative 4 DMFJBZI MI TTRA6BO DMFJBZI MN Bromodomain-containing protein 4 (BRD4) DMFJBZI MT DTT DMFJBZI MA Inhibitor DMFJBZI RN BET inhibitors in cancer therapeutics: a patent review.Expert Opin Ther Pat. 2016;26(4):505-22. DMFJBZI RU https://www.ncbi.nlm.nih.gov/pubmed/26924192 DMMX0N5 DI DMMX0N5 DMMX0N5 DN Pyrrolo-pyrrolone derivative 5 DMMX0N5 MI TTRA6BO DMMX0N5 MN Bromodomain-containing protein 4 (BRD4) DMMX0N5 MT DTT DMMX0N5 MA Inhibitor DMMX0N5 RN BET inhibitors in cancer therapeutics: a patent review.Expert Opin Ther Pat. 2016;26(4):505-22. DMMX0N5 RU https://www.ncbi.nlm.nih.gov/pubmed/26924192 DMBW208 DI DMBW208 DMBW208 DN Pyrrolo-pyrrolone derivative 6 DMBW208 MI TTFRCTK DMBW208 MN CREB-binding protein (CREBBP) DMBW208 MT DTT DMBW208 MA Inhibitor DMBW208 RN BET inhibitors in cancer therapeutics: a patent review.Expert Opin Ther Pat. 2016;26(4):505-22. DMBW208 RU https://www.ncbi.nlm.nih.gov/pubmed/26924192 DM4DJA7 DI DM4DJA7 DM4DJA7 DN QCPOIDRINIAUKU-SRBBEKPSSA-N DM4DJA7 MI TTXHWA7 DM4DJA7 MN Ubiquitin-activating enzyme E1 (UBAE1) DM4DJA7 MT DTT DM4DJA7 MA Inhibitor DM4DJA7 RN Pyrazolopyrimidinyl inhibitors of ubiquitin-activating enzyme. US10202389. DM4DJA7 RU http://www.freepatentsonline.com/US10202389.html DMH86F2 DI DMH86F2 DMH86F2 DN Quinazoline alkaloid derivative 1 DMH86F2 MI TT1RS9F DMH86F2 MN Acetylcholinesterase (AChE) DMH86F2 MT DTT DMH86F2 MA Inhibitor DMH86F2 RN A patent review of butyrylcholinesterase inhibitors and reactivators 2010-2017.Expert Opin Ther Pat. 2018 Jun;28(6):455-465. DMH86F2 RU https://www.ncbi.nlm.nih.gov/pubmed/29757691 DMH86F2 DI DMH86F2 DMH86F2 DN Quinazoline alkaloid derivative 1 DMH86F2 MI TTEB0GD DMH86F2 MN Cholinesterase (BCHE) DMH86F2 MT DTT DMH86F2 MA Inhibitor DMH86F2 RN A patent review of butyrylcholinesterase inhibitors and reactivators 2010-2017.Expert Opin Ther Pat. 2018 Jun;28(6):455-465. DMH86F2 RU https://www.ncbi.nlm.nih.gov/pubmed/29757691 DMOBFAU DI DMOBFAU DMOBFAU DN Quinazoline derivative 1 DMOBFAU MI TTDIGC1 DMOBFAU MN Dipeptidyl peptidase 4 (DPP-4) DMOBFAU MT DTT DMOBFAU MA Inhibitor DMOBFAU RN DPP-4 inhibitors: a patent review (2012 - 2014).Expert Opin Ther Pat. 2015 Feb;25(2):209-36. DMOBFAU RU https://www.ncbi.nlm.nih.gov/pubmed/25482888 DMZ3ORT DI DMZ3ORT DMZ3ORT DN Quinazoline derivative 10 DMZ3ORT MI TTQR74A DMZ3ORT MN Proteinase activated receptor 2 (PAR2) DMZ3ORT MT DTT DMZ3ORT MA Antagonist DMZ3ORT RN Protease activated receptor 2 (PAR2) modulators: a patent review (2010-2015).Expert Opin Ther Pat. 2016;26(4):471-83. DMZ3ORT RU https://www.ncbi.nlm.nih.gov/pubmed/26936077 DMAH435 DI DMAH435 DMAH435 DN Quinazoline derivative 11 DMAH435 MI TTQR74A DMAH435 MN Proteinase activated receptor 2 (PAR2) DMAH435 MT DTT DMAH435 MA Antagonist DMAH435 RN Protease activated receptor 2 (PAR2) modulators: a patent review (2010-2015).Expert Opin Ther Pat. 2016;26(4):471-83. DMAH435 RU https://www.ncbi.nlm.nih.gov/pubmed/26936077 DMVKZU2 DI DMVKZU2 DMVKZU2 DN Quinazoline derivative 12 DMVKZU2 MI TTQR74A DMVKZU2 MN Proteinase activated receptor 2 (PAR2) DMVKZU2 MT DTT DMVKZU2 MA Antagonist DMVKZU2 RN Protease activated receptor 2 (PAR2) modulators: a patent review (2010-2015).Expert Opin Ther Pat. 2016;26(4):471-83. DMVKZU2 RU https://www.ncbi.nlm.nih.gov/pubmed/26936077 DMFU6OD DI DMFU6OD DMFU6OD DN Quinazoline derivative 13 DMFU6OD MI TTQR74A DMFU6OD MN Proteinase activated receptor 2 (PAR2) DMFU6OD MT DTT DMFU6OD MA Antagonist DMFU6OD RN Protease activated receptor 2 (PAR2) modulators: a patent review (2010-2015).Expert Opin Ther Pat. 2016;26(4):471-83. DMFU6OD RU https://www.ncbi.nlm.nih.gov/pubmed/26936077 DMHLJA7 DI DMHLJA7 DMHLJA7 DN Quinazoline derivative 14 DMHLJA7 MI TT4DXQT DMHLJA7 MN Proto-oncogene c-Ret (RET) DMHLJA7 MT DTT DMHLJA7 MA Inhibitor DMHLJA7 RN RET kinase inhibitors: a review of recent patents (2012-2015).Expert Opin Ther Pat. 2017 Jan;27(1):91-99. DMHLJA7 RU https://www.ncbi.nlm.nih.gov/pubmed/27646564 DMD965S DI DMD965S DMD965S DN Quinazoline derivative 15 DMD965S MI TT4DXQT DMD965S MN Proto-oncogene c-Ret (RET) DMD965S MT DTT DMD965S MA Inhibitor DMD965S RN RET kinase inhibitors: a review of recent patents (2012-2015).Expert Opin Ther Pat. 2017 Jan;27(1):91-99. DMD965S RU https://www.ncbi.nlm.nih.gov/pubmed/27646564 DMD965S DI DMD965S DMD965S DN Quinazoline derivative 15 DMD965S MI TTUTJGQ DMD965S MN Vascular endothelial growth factor receptor 2 (KDR) DMD965S MT DTT DMD965S MA Inhibitor DMD965S RN RET kinase inhibitors: a review of recent patents (2012-2015).Expert Opin Ther Pat. 2017 Jan;27(1):91-99. DMD965S RU https://www.ncbi.nlm.nih.gov/pubmed/27646564 DMQ704Z DI DMQ704Z DMQ704Z DN Quinazoline derivative 16 DMQ704Z MI TT4DXQT DMQ704Z MN Proto-oncogene c-Ret (RET) DMQ704Z MT DTT DMQ704Z MA Inhibitor DMQ704Z RN RET kinase inhibitors: a review of recent patents (2012-2015).Expert Opin Ther Pat. 2017 Jan;27(1):91-99. DMQ704Z RU https://www.ncbi.nlm.nih.gov/pubmed/27646564 DMQ704Z DI DMQ704Z DMQ704Z DN Quinazoline derivative 16 DMQ704Z MI TTUTJGQ DMQ704Z MN Vascular endothelial growth factor receptor 2 (KDR) DMQ704Z MT DTT DMQ704Z MA Inhibitor DMQ704Z RN RET kinase inhibitors: a review of recent patents (2012-2015).Expert Opin Ther Pat. 2017 Jan;27(1):91-99. DMQ704Z RU https://www.ncbi.nlm.nih.gov/pubmed/27646564 DMGECO2 DI DMGECO2 DMGECO2 DN Quinazoline derivative 2 DMGECO2 MI TTPTXIN DMGECO2 MN Translocator protein (TSPO) DMGECO2 MT DTT DMGECO2 MA Ligand DMGECO2 RN Translocator protein (TSPO) ligands for the diagnosis or treatment of neurodegenerative diseases: a patent review (2010-2015; part 1).Expert Opin Ther Pat. 2016 Nov;26(11):1325-1351. DMGECO2 RU https://www.ncbi.nlm.nih.gov/pubmed/27607364 DMF05GL DI DMF05GL DMF05GL DN Quinazoline derivative 3 DMF05GL MI TTPTXIN DMF05GL MN Translocator protein (TSPO) DMF05GL MT DTT DMF05GL MA Ligand DMF05GL RN Translocator protein (TSPO) ligands for the diagnosis or treatment of neurodegenerative diseases: a patent review (2010-2015; part 1).Expert Opin Ther Pat. 2016 Nov;26(11):1325-1351. DMF05GL RU https://www.ncbi.nlm.nih.gov/pubmed/27607364 DMJIDLU DI DMJIDLU DMJIDLU DN Quinazoline derivative 4 DMJIDLU MI TTPTXIN DMJIDLU MN Translocator protein (TSPO) DMJIDLU MT DTT DMJIDLU MA Ligand DMJIDLU RN Translocator protein (TSPO) ligands for the diagnosis or treatment of neurodegenerative diseases: a patent review (2010-2015; part 1).Expert Opin Ther Pat. 2016 Nov;26(11):1325-1351. DMJIDLU RU https://www.ncbi.nlm.nih.gov/pubmed/27607364 DMEIH73 DI DMEIH73 DMEIH73 DN Quinazoline derivative 5 DMEIH73 MI TTPTXIN DMEIH73 MN Translocator protein (TSPO) DMEIH73 MT DTT DMEIH73 MA Ligand DMEIH73 RN Translocator protein (TSPO) ligands for the diagnosis or treatment of neurodegenerative diseases: a patent review (2010-2015; part 1).Expert Opin Ther Pat. 2016 Nov;26(11):1325-1351. DMEIH73 RU https://www.ncbi.nlm.nih.gov/pubmed/27607364 DMKZ6MD DI DMKZ6MD DMKZ6MD DN Quinazoline derivative 6 DMKZ6MD MI TTPTXIN DMKZ6MD MN Translocator protein (TSPO) DMKZ6MD MT DTT DMKZ6MD MA Ligand DMKZ6MD RN Translocator protein (TSPO) ligands for the diagnosis or treatment of neurodegenerative diseases: a patent review (2010-2015; part 1).Expert Opin Ther Pat. 2016 Nov;26(11):1325-1351. DMKZ6MD RU https://www.ncbi.nlm.nih.gov/pubmed/27607364 DMIBRE5 DI DMIBRE5 DMIBRE5 DN Quinazoline derivative 7 DMIBRE5 MI TTPTXIN DMIBRE5 MN Translocator protein (TSPO) DMIBRE5 MT DTT DMIBRE5 MA Ligand DMIBRE5 RN Translocator protein (TSPO) ligands for the diagnosis or treatment of neurodegenerative diseases: a patent review (2010-2015; part 1).Expert Opin Ther Pat. 2016 Nov;26(11):1325-1351. DMIBRE5 RU https://www.ncbi.nlm.nih.gov/pubmed/27607364 DMSD04W DI DMSD04W DMSD04W DN Quinazolinedione derivative 1 DMSD04W MI TTVDSZ0 DMSD04W MN Poly [ADP-ribose] polymerase 1 (PARP1) DMSD04W MT DTT DMSD04W MA Inhibitor DMSD04W RN PARP inhibitors as antitumor agents: a patent update (2013-2015).Expert Opin Ther Pat. 2017 Mar;27(3):363-382. DMSD04W RU https://www.ncbi.nlm.nih.gov/pubmed/27841036 DM3TVI6 DI DM3TVI6 DM3TVI6 DN Quinazolinedione derivative 2 DM3TVI6 MI TTVDSZ0 DM3TVI6 MN Poly [ADP-ribose] polymerase 1 (PARP1) DM3TVI6 MT DTT DM3TVI6 MA Inhibitor DM3TVI6 RN PARP inhibitors as antitumor agents: a patent update (2013-2015).Expert Opin Ther Pat. 2017 Mar;27(3):363-382. DM3TVI6 RU https://www.ncbi.nlm.nih.gov/pubmed/27841036 DMZ5GIH DI DMZ5GIH DMZ5GIH DN Quinazolinedione derivative 3 DMZ5GIH MI TTVDSZ0 DMZ5GIH MN Poly [ADP-ribose] polymerase 1 (PARP1) DMZ5GIH MT DTT DMZ5GIH MA Inhibitor DMZ5GIH RN PARP inhibitors as antitumor agents: a patent update (2013-2015).Expert Opin Ther Pat. 2017 Mar;27(3):363-382. DMZ5GIH RU https://www.ncbi.nlm.nih.gov/pubmed/27841036 DME24BI DI DME24BI DME24BI DN Quinazolines and azaquinazoline derivative 1 DME24BI MI TTZCRP3 DME24BI MN ERK activator kinase (MEK) DME24BI MT DTT DME24BI MA Inhibitor DME24BI RN MEK inhibitors in oncology: a patent review (2015-Present).Expert Opin Ther Pat. 2017 Aug;27(8):887-906. DME24BI RU https://www.ncbi.nlm.nih.gov/pubmed/28594589 DMSU1PC DI DMSU1PC DMSU1PC DN Quinazolinone derivative 1 DMSU1PC MI TTL7C8Q DMSU1PC MN Inosine-5'-monophosphate dehydrogenase 1 (IMPDH1) DMSU1PC MT DTT DMSU1PC MA Inhibitor DMSU1PC RN Inosine-5'-monophosphate dehydrogenase (IMPDH) inhibitors: a patent and scientific literature review (2002-2016).Expert Opin Ther Pat. 2017 Jun;27(6):677-690. DMSU1PC RU https://www.ncbi.nlm.nih.gov/pubmed/28074661 DM0XVQY DI DM0XVQY DM0XVQY DN Quinazolinone derivative 2 DM0XVQY MI TTL7C8Q DM0XVQY MN Inosine-5'-monophosphate dehydrogenase 1 (IMPDH1) DM0XVQY MT DTT DM0XVQY MA Inhibitor DM0XVQY RN Inosine-5'-monophosphate dehydrogenase (IMPDH) inhibitors: a patent and scientific literature review (2002-2016).Expert Opin Ther Pat. 2017 Jun;27(6):677-690. DM0XVQY RU https://www.ncbi.nlm.nih.gov/pubmed/28074661 DMDRIZF DI DMDRIZF DMDRIZF DN Quinazolinone derivative 3 DMDRIZF MI TTE4BSY DMDRIZF MN Bromodomain and extraterminal domain protein (BET) DMDRIZF MT DTT DMDRIZF MA Inhibitor DMDRIZF RN BET inhibitors in cancer therapeutics: a patent review.Expert Opin Ther Pat. 2016;26(4):505-22. DMDRIZF RU https://www.ncbi.nlm.nih.gov/pubmed/26924192 DM8WH97 DI DM8WH97 DM8WH97 DN Quinazolinone derivative 4 DM8WH97 MI TTE4BSY DM8WH97 MN Bromodomain and extraterminal domain protein (BET) DM8WH97 MT DTT DM8WH97 MA Inhibitor DM8WH97 RN BET inhibitors in cancer therapeutics: a patent review.Expert Opin Ther Pat. 2016;26(4):505-22. DM8WH97 RU https://www.ncbi.nlm.nih.gov/pubmed/26924192 DMXOKH3 DI DMXOKH3 DMXOKH3 DN Quinazolinone derivative 5 DMXOKH3 MI TTE4BSY DMXOKH3 MN Bromodomain and extraterminal domain protein (BET) DMXOKH3 MT DTT DMXOKH3 MA Inhibitor DMXOKH3 RN BET inhibitors in cancer therapeutics: a patent review.Expert Opin Ther Pat. 2016;26(4):505-22. DMXOKH3 RU https://www.ncbi.nlm.nih.gov/pubmed/26924192 DMKDTO4 DI DMKDTO4 DMKDTO4 DN Quinoline and quinazoline derivative 1 DMKDTO4 MI TTUTJGQ DMKDTO4 MN Vascular endothelial growth factor receptor 2 (KDR) DMKDTO4 MT DTT DMKDTO4 MA Inhibitor DMKDTO4 RN VEGFR-2 inhibitors and the therapeutic applications thereof: a patent review (2012-2016).Expert Opin Ther Pat. 2017 Sep;27(9):987-1004. DMKDTO4 RU https://www.ncbi.nlm.nih.gov/pubmed/28621580 DM6E1N4 DI DM6E1N4 DM6E1N4 DN Quinoline and quinazoline derivative 10 DM6E1N4 MI TTOHSBA DM6E1N4 MN Vascular endothelial growth factor A (VEGFA) DM6E1N4 MT DTT DM6E1N4 MA Inhibitor DM6E1N4 RN VEGFR-2 inhibitors and the therapeutic applications thereof: a patent review (2012-2016).Expert Opin Ther Pat. 2017 Sep;27(9):987-1004. DM6E1N4 RU https://www.ncbi.nlm.nih.gov/pubmed/28621580 DM9PSI3 DI DM9PSI3 DM9PSI3 DN Quinoline and quinazoline derivative 2 DM9PSI3 MI TTOHSBA DM9PSI3 MN Vascular endothelial growth factor A (VEGFA) DM9PSI3 MT DTT DM9PSI3 MA Inhibitor DM9PSI3 RN VEGFR-2 inhibitors and the therapeutic applications thereof: a patent review (2012-2016).Expert Opin Ther Pat. 2017 Sep;27(9):987-1004. DM9PSI3 RU https://www.ncbi.nlm.nih.gov/pubmed/28621580 DMGY4WO DI DMGY4WO DMGY4WO DN Quinoline and quinazoline derivative 3 DMGY4WO MI TTOHSBA DMGY4WO MN Vascular endothelial growth factor A (VEGFA) DMGY4WO MT DTT DMGY4WO MA Inhibitor DMGY4WO RN VEGFR-2 inhibitors and the therapeutic applications thereof: a patent review (2012-2016).Expert Opin Ther Pat. 2017 Sep;27(9):987-1004. DMGY4WO RU https://www.ncbi.nlm.nih.gov/pubmed/28621580 DM5VCQP DI DM5VCQP DM5VCQP DN Quinoline and quinazoline derivative 4 DM5VCQP MI TTOHSBA DM5VCQP MN Vascular endothelial growth factor A (VEGFA) DM5VCQP MT DTT DM5VCQP MA Inhibitor DM5VCQP RN VEGFR-2 inhibitors and the therapeutic applications thereof: a patent review (2012-2016).Expert Opin Ther Pat. 2017 Sep;27(9):987-1004. DM5VCQP RU https://www.ncbi.nlm.nih.gov/pubmed/28621580 DM7RQ2G DI DM7RQ2G DM7RQ2G DN Quinoline and quinazoline derivative 5 DM7RQ2G MI TTOHSBA DM7RQ2G MN Vascular endothelial growth factor A (VEGFA) DM7RQ2G MT DTT DM7RQ2G MA Inhibitor DM7RQ2G RN VEGFR-2 inhibitors and the therapeutic applications thereof: a patent review (2012-2016).Expert Opin Ther Pat. 2017 Sep;27(9):987-1004. DM7RQ2G RU https://www.ncbi.nlm.nih.gov/pubmed/28621580 DMZ2TB5 DI DMZ2TB5 DMZ2TB5 DN Quinoline and quinazoline derivative 6 DMZ2TB5 MI TTOHSBA DMZ2TB5 MN Vascular endothelial growth factor A (VEGFA) DMZ2TB5 MT DTT DMZ2TB5 MA Inhibitor DMZ2TB5 RN VEGFR-2 inhibitors and the therapeutic applications thereof: a patent review (2012-2016).Expert Opin Ther Pat. 2017 Sep;27(9):987-1004. DMZ2TB5 RU https://www.ncbi.nlm.nih.gov/pubmed/28621580 DMMJEWB DI DMMJEWB DMMJEWB DN Quinoline and quinazoline derivative 7 DMMJEWB MI TTOHSBA DMMJEWB MN Vascular endothelial growth factor A (VEGFA) DMMJEWB MT DTT DMMJEWB MA Inhibitor DMMJEWB RN VEGFR-2 inhibitors and the therapeutic applications thereof: a patent review (2012-2016).Expert Opin Ther Pat. 2017 Sep;27(9):987-1004. DMMJEWB RU https://www.ncbi.nlm.nih.gov/pubmed/28621580 DMW3JH0 DI DMW3JH0 DMW3JH0 DN Quinoline and quinazoline derivative 8 DMW3JH0 MI TTOHSBA DMW3JH0 MN Vascular endothelial growth factor A (VEGFA) DMW3JH0 MT DTT DMW3JH0 MA Inhibitor DMW3JH0 RN VEGFR-2 inhibitors and the therapeutic applications thereof: a patent review (2012-2016).Expert Opin Ther Pat. 2017 Sep;27(9):987-1004. DMW3JH0 RU https://www.ncbi.nlm.nih.gov/pubmed/28621580 DMBL86O DI DMBL86O DMBL86O DN Quinoline and quinazoline derivative 9 DMBL86O MI TTOHSBA DMBL86O MN Vascular endothelial growth factor A (VEGFA) DMBL86O MT DTT DMBL86O MA Inhibitor DMBL86O RN VEGFR-2 inhibitors and the therapeutic applications thereof: a patent review (2012-2016).Expert Opin Ther Pat. 2017 Sep;27(9):987-1004. DMBL86O RU https://www.ncbi.nlm.nih.gov/pubmed/28621580 DMW5YJB DI DMW5YJB DMW5YJB DN Quinoline carboxamide derivative 1 DMW5YJB MI TTH8FZW DMW5YJB MN Signal transducer and activator of transcription 3 (STAT3) DMW5YJB MT DTT DMW5YJB MA Inhibitor DMW5YJB RN A STAT inhibitor patent review: progress since 2011.Expert Opin Ther Pat. 2015;25(12):1397-421. DMW5YJB RU https://www.ncbi.nlm.nih.gov/pubmed/26394986 DMZTQVF DI DMZTQVF DMZTQVF DN Quinoline carboxamide derivative 10 DMZTQVF MI TTPTXIN DMZTQVF MN Translocator protein (TSPO) DMZTQVF MT DTT DMZTQVF MA Ligand DMZTQVF RN Translocator protein (TSPO) ligands for the diagnosis or treatment of neurodegenerative diseases: a patent review (2010-2015; part 1).Expert Opin Ther Pat. 2016 Nov;26(11):1325-1351. DMZTQVF RU https://www.ncbi.nlm.nih.gov/pubmed/27607364 DM9XQBG DI DM9XQBG DM9XQBG DN Quinoline carboxamide derivative 2 DM9XQBG MI TTH8FZW DM9XQBG MN Signal transducer and activator of transcription 3 (STAT3) DM9XQBG MT DTT DM9XQBG MA Inhibitor DM9XQBG RN A STAT inhibitor patent review: progress since 2011.Expert Opin Ther Pat. 2015;25(12):1397-421. DM9XQBG RU https://www.ncbi.nlm.nih.gov/pubmed/26394986 DMCAS85 DI DMCAS85 DMCAS85 DN Quinoline carboxamide derivative 3 DMCAS85 MI TTH8FZW DMCAS85 MN Signal transducer and activator of transcription 3 (STAT3) DMCAS85 MT DTT DMCAS85 MA Inhibitor DMCAS85 RN A STAT inhibitor patent review: progress since 2011.Expert Opin Ther Pat. 2015;25(12):1397-421. DMCAS85 RU https://www.ncbi.nlm.nih.gov/pubmed/26394986 DMVUNYD DI DMVUNYD DMVUNYD DN Quinoline carboxamide derivative 4 DMVUNYD MI TTPTXIN DMVUNYD MN Translocator protein (TSPO) DMVUNYD MT DTT DMVUNYD MA Ligand DMVUNYD RN Translocator protein (TSPO) ligands for the diagnosis or treatment of neurodegenerative diseases: a patent review (2010-2015; part 1).Expert Opin Ther Pat. 2016 Nov;26(11):1325-1351. DMVUNYD RU https://www.ncbi.nlm.nih.gov/pubmed/27607364 DM14029 DI DM14029 DM14029 DN Quinoline carboxamide derivative 5 DM14029 MI TTPTXIN DM14029 MN Translocator protein (TSPO) DM14029 MT DTT DM14029 MA Ligand DM14029 RN Translocator protein (TSPO) ligands for the diagnosis or treatment of neurodegenerative diseases: a patent review (2010-2015; part 1).Expert Opin Ther Pat. 2016 Nov;26(11):1325-1351. DM14029 RU https://www.ncbi.nlm.nih.gov/pubmed/27607364 DMQ9ATN DI DMQ9ATN DMQ9ATN DN Quinoline carboxamide derivative 6 DMQ9ATN MI TTPTXIN DMQ9ATN MN Translocator protein (TSPO) DMQ9ATN MT DTT DMQ9ATN MA Ligand DMQ9ATN RN Translocator protein (TSPO) ligands for the diagnosis or treatment of neurodegenerative diseases: a patent review (2010-2015; part 1).Expert Opin Ther Pat. 2016 Nov;26(11):1325-1351. DMQ9ATN RU https://www.ncbi.nlm.nih.gov/pubmed/27607364 DM8AG0Z DI DM8AG0Z DM8AG0Z DN Quinoline carboxamide derivative 7 DM8AG0Z MI TTPTXIN DM8AG0Z MN Translocator protein (TSPO) DM8AG0Z MT DTT DM8AG0Z MA Ligand DM8AG0Z RN Translocator protein (TSPO) ligands for the diagnosis or treatment of neurodegenerative diseases: a patent review (2010-2015; part 1).Expert Opin Ther Pat. 2016 Nov;26(11):1325-1351. DM8AG0Z RU https://www.ncbi.nlm.nih.gov/pubmed/27607364 DM3IXYL DI DM3IXYL DM3IXYL DN Quinoline carboxamide derivative 8 DM3IXYL MI TTPTXIN DM3IXYL MN Translocator protein (TSPO) DM3IXYL MT DTT DM3IXYL MA Ligand DM3IXYL RN Translocator protein (TSPO) ligands for the diagnosis or treatment of neurodegenerative diseases: a patent review (2010-2015; part 1).Expert Opin Ther Pat. 2016 Nov;26(11):1325-1351. DM3IXYL RU https://www.ncbi.nlm.nih.gov/pubmed/27607364 DM7YFBT DI DM7YFBT DM7YFBT DN Quinoline carboxamide derivative 9 DM7YFBT MI TTPTXIN DM7YFBT MN Translocator protein (TSPO) DM7YFBT MT DTT DM7YFBT MA Ligand DM7YFBT RN Translocator protein (TSPO) ligands for the diagnosis or treatment of neurodegenerative diseases: a patent review (2010-2015; part 1).Expert Opin Ther Pat. 2016 Nov;26(11):1325-1351. DM7YFBT RU https://www.ncbi.nlm.nih.gov/pubmed/27607364 DMRY2HL DI DMRY2HL DMRY2HL DN Quinoline derivative 1 DMRY2HL MI TTPADOQ DMRY2HL MN HMG-CoA reductase (HMGCR) DMRY2HL MT DTT DMRY2HL MA Inhibitor DMRY2HL RN HMG-CoA Reductase inhibitors: an updated review of patents of novel compounds and formulations (2011-2015).Expert Opin Ther Pat. 2016 Nov;26(11):1257-1272. DMRY2HL RU https://www.ncbi.nlm.nih.gov/pubmed/27537201 DM6GSCV DI DM6GSCV DM6GSCV DN Quinoline derivative 10 DM6GSCV MI TT473XN DM6GSCV MN P2X purinoceptor 7 (P2RX7) DM6GSCV MT DTT DM6GSCV MA Antagonist DM6GSCV RN P2X7 receptor antagonists: a patent review (2010-2015).Expert Opin Ther Pat. 2017 Mar;27(3):257-267. DM6GSCV RU https://www.ncbi.nlm.nih.gov/pubmed/27724045 DMH02JL DI DMH02JL DMH02JL DN Quinoline derivative 11 DMH02JL MI TT473XN DMH02JL MN P2X purinoceptor 7 (P2RX7) DMH02JL MT DTT DMH02JL MA Antagonist DMH02JL RN P2X7 receptor antagonists: a patent review (2010-2015).Expert Opin Ther Pat. 2017 Mar;27(3):257-267. DMH02JL RU https://www.ncbi.nlm.nih.gov/pubmed/27724045 DMH02JL DI DMH02JL DMH02JL DN Quinoline derivative 11 DMH02JL MI TTQ6VDM DMH02JL MN Voltage-gated potassium channel Kv11.1 (KCNH2) DMH02JL MT DTT DMH02JL MA Antagonist DMH02JL RN P2X7 receptor antagonists: a patent review (2010-2015).Expert Opin Ther Pat. 2017 Mar;27(3):257-267. DMH02JL RU https://www.ncbi.nlm.nih.gov/pubmed/27724045 DM9FXE7 DI DM9FXE7 DM9FXE7 DN Quinoline derivative 12 DM9FXE7 MI TT473XN DM9FXE7 MN P2X purinoceptor 7 (P2RX7) DM9FXE7 MT DTT DM9FXE7 MA Antagonist DM9FXE7 RN P2X7 receptor antagonists: a patent review (2010-2015).Expert Opin Ther Pat. 2017 Mar;27(3):257-267. DM9FXE7 RU https://www.ncbi.nlm.nih.gov/pubmed/27724045 DM9FXE7 DI DM9FXE7 DM9FXE7 DN Quinoline derivative 12 DM9FXE7 MI TTQ6VDM DM9FXE7 MN Voltage-gated potassium channel Kv11.1 (KCNH2) DM9FXE7 MT DTT DM9FXE7 MA Antagonist DM9FXE7 RN P2X7 receptor antagonists: a patent review (2010-2015).Expert Opin Ther Pat. 2017 Mar;27(3):257-267. DM9FXE7 RU https://www.ncbi.nlm.nih.gov/pubmed/27724045 DMAH4P8 DI DMAH4P8 DMAH4P8 DN Quinoline derivative 13 DMAH4P8 MI TT473XN DMAH4P8 MN P2X purinoceptor 7 (P2RX7) DMAH4P8 MT DTT DMAH4P8 MA Antagonist DMAH4P8 RN P2X7 receptor antagonists: a patent review (2010-2015).Expert Opin Ther Pat. 2017 Mar;27(3):257-267. DMAH4P8 RU https://www.ncbi.nlm.nih.gov/pubmed/27724045 DMAH4P8 DI DMAH4P8 DMAH4P8 DN Quinoline derivative 13 DMAH4P8 MI TTQ6VDM DMAH4P8 MN Voltage-gated potassium channel Kv11.1 (KCNH2) DMAH4P8 MT DTT DMAH4P8 MA Antagonist DMAH4P8 RN P2X7 receptor antagonists: a patent review (2010-2015).Expert Opin Ther Pat. 2017 Mar;27(3):257-267. DMAH4P8 RU https://www.ncbi.nlm.nih.gov/pubmed/27724045 DMSRB8M DI DMSRB8M DMSRB8M DN Quinoline derivative 14 DMSRB8M MI TTRZQE3 DMSRB8M MN Glycogen synthase kinase-3 alpha (GSK-3A) DMSRB8M MT DTT DMSRB8M MA Inhibitor DMSRB8M RN Glycogen synthase kinase 3 (GSK-3) inhibitors: a patent update (2014-2015).Expert Opin Ther Pat. 2017 Jun;27(6):657-666. DMSRB8M RU https://www.ncbi.nlm.nih.gov/pubmed/27828716 DM7HD0T DI DM7HD0T DM7HD0T DN Quinoline derivative 15 DM7HD0T MI TTRZQE3 DM7HD0T MN Glycogen synthase kinase-3 alpha (GSK-3A) DM7HD0T MT DTT DM7HD0T MA Inhibitor DM7HD0T RN Glycogen synthase kinase 3 (GSK-3) inhibitors: a patent update (2014-2015).Expert Opin Ther Pat. 2017 Jun;27(6):657-666. DM7HD0T RU https://www.ncbi.nlm.nih.gov/pubmed/27828716 DMTHG87 DI DMTHG87 DMTHG87 DN Quinoline derivative 16 DMTHG87 MI TTPADOQ DMTHG87 MN HMG-CoA reductase (HMGCR) DMTHG87 MT DTT DMTHG87 MA Inhibitor DMTHG87 RN HMG-CoA Reductase inhibitors: an updated review of patents of novel compounds and formulations (2011-2015).Expert Opin Ther Pat. 2016 Nov;26(11):1257-1272. DMTHG87 RU https://www.ncbi.nlm.nih.gov/pubmed/27537201 DMKULV8 DI DMKULV8 DMKULV8 DN Quinoline derivative 17 DMKULV8 MI TTPADOQ DMKULV8 MN HMG-CoA reductase (HMGCR) DMKULV8 MT DTT DMKULV8 MA Inhibitor DMKULV8 RN HMG-CoA Reductase inhibitors: an updated review of patents of novel compounds and formulations (2011-2015).Expert Opin Ther Pat. 2016 Nov;26(11):1257-1272. DMKULV8 RU https://www.ncbi.nlm.nih.gov/pubmed/27537201 DMSG71Z DI DMSG71Z DMSG71Z DN Quinoline derivative 18 DMSG71Z MI TTSCO7R DMSG71Z MN NAD-dependent deacetylase sirtuin (SIRT) DMSG71Z MT DTT DMSG71Z MA Inhibitor DMSG71Z RN Sirtuin modulators: an updated patent review (2012 - 2014).Expert Opin Ther Pat. 2015 Jan;25(1):5-15. DMSG71Z RU https://www.ncbi.nlm.nih.gov/pubmed/25435179 DM0MLI9 DI DM0MLI9 DM0MLI9 DN Quinoline derivative 19 DM0MLI9 MI TTSCO7R DM0MLI9 MN NAD-dependent deacetylase sirtuin (SIRT) DM0MLI9 MT DTT DM0MLI9 MA Inhibitor DM0MLI9 RN Sirtuin modulators: an updated patent review (2012 - 2014).Expert Opin Ther Pat. 2015 Jan;25(1):5-15. DM0MLI9 RU https://www.ncbi.nlm.nih.gov/pubmed/25435179 DMNO2BP DI DMNO2BP DMNO2BP DN Quinoline derivative 2 DMNO2BP MI TT0K1SC DMNO2BP MN 5-HT 2B receptor (HTR2B) DMNO2BP MT DTT DMNO2BP MA Antagonist DMNO2BP RN Novel serotonin receptor 2 (5-HT2R) agonists and antagonists: a patent review (2004-2014).Expert Opin Ther Pat. 2016;26(1):89-106. DMNO2BP RU https://www.ncbi.nlm.nih.gov/pubmed/26609882 DMNO2BP DI DMNO2BP DMNO2BP DN Quinoline derivative 2 DMNO2BP MI TTWJBZ5 DMNO2BP MN 5-HT 2C receptor (HTR2C) DMNO2BP MT DTT DMNO2BP MA Agonist DMNO2BP RN Novel serotonin receptor 2 (5-HT2R) agonists and antagonists: a patent review (2004-2014).Expert Opin Ther Pat. 2016;26(1):89-106. DMNO2BP RU https://www.ncbi.nlm.nih.gov/pubmed/26609882 DMNXCZT DI DMNXCZT DMNXCZT DN Quinoline derivative 20 DMNXCZT MI TTSCO7R DMNXCZT MN NAD-dependent deacetylase sirtuin (SIRT) DMNXCZT MT DTT DMNXCZT MA Inhibitor DMNXCZT RN Sirtuin modulators: an updated patent review (2012 - 2014).Expert Opin Ther Pat. 2015 Jan;25(1):5-15. DMNXCZT RU https://www.ncbi.nlm.nih.gov/pubmed/25435179 DMDV6EY DI DMDV6EY DMDV6EY DN Quinoline derivative 3 DMDV6EY MI TTXJ47W DMDV6EY MN Metabotropic glutamate receptor 2 (mGluR2) DMDV6EY MT DTT DMDV6EY MA Antagonist DMDV6EY RN Novel metabotropic glutamate receptor 2/3 antagonists and their therapeutic applications: a patent review (2005 - present).Expert Opin Ther Pat. 2015 Jan;25(1):69-90. DMDV6EY RU https://www.ncbi.nlm.nih.gov/pubmed/25435285 DMPB4L6 DI DMPB4L6 DMPB4L6 DN Quinoline derivative 4 DMPB4L6 MI TTXJ47W DMPB4L6 MN Metabotropic glutamate receptor 2 (mGluR2) DMPB4L6 MT DTT DMPB4L6 MA Antagonist DMPB4L6 RN Novel metabotropic glutamate receptor 2/3 antagonists and their therapeutic applications: a patent review (2005 - present).Expert Opin Ther Pat. 2015 Jan;25(1):69-90. DMPB4L6 RU https://www.ncbi.nlm.nih.gov/pubmed/25435285 DMS1TOX DI DMS1TOX DMS1TOX DN Quinoline derivative 5 DMS1TOX MI TTXJ47W DMS1TOX MN Metabotropic glutamate receptor 2 (mGluR2) DMS1TOX MT DTT DMS1TOX MA Antagonist DMS1TOX RN Novel metabotropic glutamate receptor 2/3 antagonists and their therapeutic applications: a patent review (2005 - present).Expert Opin Ther Pat. 2015 Jan;25(1):69-90. DMS1TOX RU https://www.ncbi.nlm.nih.gov/pubmed/25435285 DMVBPGI DI DMVBPGI DMVBPGI DN Quinoline derivative 6 DMVBPGI MI TTXJ47W DMVBPGI MN Metabotropic glutamate receptor 2 (mGluR2) DMVBPGI MT DTT DMVBPGI MA Antagonist DMVBPGI RN Novel metabotropic glutamate receptor 2/3 antagonists and their therapeutic applications: a patent review (2005 - present).Expert Opin Ther Pat. 2015 Jan;25(1):69-90. DMVBPGI RU https://www.ncbi.nlm.nih.gov/pubmed/25435285 DM56I8H DI DM56I8H DM56I8H DN Quinoline derivative 7 DM56I8H MI TTXJ47W DM56I8H MN Metabotropic glutamate receptor 2 (mGluR2) DM56I8H MT DTT DM56I8H MA Antagonist DM56I8H RN Novel metabotropic glutamate receptor 2/3 antagonists and their therapeutic applications: a patent review (2005 - present).Expert Opin Ther Pat. 2015 Jan;25(1):69-90. DM56I8H RU https://www.ncbi.nlm.nih.gov/pubmed/25435285 DMLIW1X DI DMLIW1X DMLIW1X DN Quinoline derivative 8 DMLIW1X MI TTXJ47W DMLIW1X MN Metabotropic glutamate receptor 2 (mGluR2) DMLIW1X MT DTT DMLIW1X MA Antagonist DMLIW1X RN Novel metabotropic glutamate receptor 2/3 antagonists and their therapeutic applications: a patent review (2005 - present).Expert Opin Ther Pat. 2015 Jan;25(1):69-90. DMLIW1X RU https://www.ncbi.nlm.nih.gov/pubmed/25435285 DMIC86N DI DMIC86N DMIC86N DN Quinoline derivative 9 DMIC86N MI TTXJ47W DMIC86N MN Metabotropic glutamate receptor 2 (mGluR2) DMIC86N MT DTT DMIC86N MA Antagonist DMIC86N RN Novel metabotropic glutamate receptor 2/3 antagonists and their therapeutic applications: a patent review (2005 - present).Expert Opin Ther Pat. 2015 Jan;25(1):69-90. DMIC86N RU https://www.ncbi.nlm.nih.gov/pubmed/25435285 DMENZPR DI DMENZPR DMENZPR DN Quinolinyl compound 1 DMENZPR MI TT9O6WS DMENZPR MN Glucagon receptor (GCGR) DMENZPR MT DTT DMENZPR MA Antagonist DMENZPR RN Small molecule glucagon receptor antagonists: a patent review (2011 - 2014).Expert Opin Ther Pat. 2015 Jul;25(7):819-30. DMENZPR RU https://www.ncbi.nlm.nih.gov/pubmed/25828189 DMGLK92 DI DMGLK92 DMGLK92 DN Quinolinyl compound 2 DMGLK92 MI TT9O6WS DMGLK92 MN Glucagon receptor (GCGR) DMGLK92 MT DTT DMGLK92 MA Antagonist DMGLK92 RN Small molecule glucagon receptor antagonists: a patent review (2011 - 2014).Expert Opin Ther Pat. 2015 Jul;25(7):819-30. DMGLK92 RU https://www.ncbi.nlm.nih.gov/pubmed/25828189 DMCIKR3 DI DMCIKR3 DMCIKR3 DN Quinolinyl pyrazinyl urea derivative 1 DMCIKR3 MI TTRZQE3 DMCIKR3 MN Glycogen synthase kinase-3 alpha (GSK-3A) DMCIKR3 MT DTT DMCIKR3 MA Inhibitor DMCIKR3 RN Glycogen synthase kinase 3 (GSK-3) inhibitors: a patent update (2014-2015).Expert Opin Ther Pat. 2017 Jun;27(6):657-666. DMCIKR3 RU https://www.ncbi.nlm.nih.gov/pubmed/27828716 DMKJN9G DI DMKJN9G DMKJN9G DN Quinolinyl pyrazinyl urea derivative 2 DMKJN9G MI TTRZQE3 DMKJN9G MN Glycogen synthase kinase-3 alpha (GSK-3A) DMKJN9G MT DTT DMKJN9G MA Inhibitor DMKJN9G RN Glycogen synthase kinase 3 (GSK-3) inhibitors: a patent update (2014-2015).Expert Opin Ther Pat. 2017 Jun;27(6):657-666. DMKJN9G RU https://www.ncbi.nlm.nih.gov/pubmed/27828716 DME6P7T DI DME6P7T DME6P7T DN Quinolone derivative 1 DME6P7T MI TTL7C8Q DME6P7T MN Inosine-5'-monophosphate dehydrogenase 1 (IMPDH1) DME6P7T MT DTT DME6P7T MA Inhibitor DME6P7T RN Inosine-5'-monophosphate dehydrogenase (IMPDH) inhibitors: a patent and scientific literature review (2002-2016).Expert Opin Ther Pat. 2017 Jun;27(6):677-690. DME6P7T RU https://www.ncbi.nlm.nih.gov/pubmed/28074661 DMENQ5O DI DMENQ5O DMENQ5O DN Quinoxaline derivative 1 DMENQ5O MI TTSXVID DMENQ5O MN Nuclear factor NF-kappa-B (NFKB) DMENQ5O MT DTT DMENQ5O MA Inhibitor DMENQ5O RN Novel NF-B inhibitors: a patent review (2011 - 2014).Expert Opin Ther Pat. 2015 Mar;25(3):319-34. DMENQ5O RU https://www.ncbi.nlm.nih.gov/pubmed/25553724 DM031YW DI DM031YW DM031YW DN Quinoxaline derivative 2 DM031YW MI TTSXVID DM031YW MN Nuclear factor NF-kappa-B (NFKB) DM031YW MT DTT DM031YW MA Inhibitor DM031YW RN Novel NF-B inhibitors: a patent review (2011 - 2014).Expert Opin Ther Pat. 2015 Mar;25(3):319-34. DM031YW RU https://www.ncbi.nlm.nih.gov/pubmed/25553724 DMLZRAI DI DMLZRAI DMLZRAI DN Quinoxaline derivative 3 DMLZRAI MI TTSXVID DMLZRAI MN Nuclear factor NF-kappa-B (NFKB) DMLZRAI MT DTT DMLZRAI MA Inhibitor DMLZRAI RN Novel NF-B inhibitors: a patent review (2011 - 2014).Expert Opin Ther Pat. 2015 Mar;25(3):319-34. DMLZRAI RU https://www.ncbi.nlm.nih.gov/pubmed/25553724 DMS3PRT DI DMS3PRT DMS3PRT DN Quinoxaline derivative 4 DMS3PRT MI TTSXVID DMS3PRT MN Nuclear factor NF-kappa-B (NFKB) DMS3PRT MT DTT DMS3PRT MA Inhibitor DMS3PRT RN Novel NF-B inhibitors: a patent review (2011 - 2014).Expert Opin Ther Pat. 2015 Mar;25(3):319-34. DMS3PRT RU https://www.ncbi.nlm.nih.gov/pubmed/25553724 DM8EY2G DI DM8EY2G DM8EY2G DN Quinoxaline derivative 5 DM8EY2G MI TTSXVID DM8EY2G MN Nuclear factor NF-kappa-B (NFKB) DM8EY2G MT DTT DM8EY2G MA Inhibitor DM8EY2G RN Novel NF-B inhibitors: a patent review (2011 - 2014).Expert Opin Ther Pat. 2015 Mar;25(3):319-34. DM8EY2G RU https://www.ncbi.nlm.nih.gov/pubmed/25553724 DMBRX8D DI DMBRX8D DMBRX8D DN Quinoxaline derivative 6 DMBRX8D MI TTSXVID DMBRX8D MN Nuclear factor NF-kappa-B (NFKB) DMBRX8D MT DTT DMBRX8D MA Inhibitor DMBRX8D RN Novel NF-B inhibitors: a patent review (2011 - 2014).Expert Opin Ther Pat. 2015 Mar;25(3):319-34. DMBRX8D RU https://www.ncbi.nlm.nih.gov/pubmed/25553724 DMG4FYP DI DMG4FYP DMG4FYP DN Resorcinol compound 1 DMG4FYP MI TTULVH8 DMG4FYP MN Tyrosinase (TYR) DMG4FYP MT DTT DMG4FYP MA Inhibitor DMG4FYP RN Tyrosinase inhibitors: a patent review (2011-2015).Expert Opin Ther Pat. 2016;26(3):347-62. DMG4FYP RU https://www.ncbi.nlm.nih.gov/pubmed/26815044 DMPA26U DI DMPA26U DMPA26U DN Resorcinol compound 10 DMPA26U MI TTULVH8 DMPA26U MN Tyrosinase (TYR) DMPA26U MT DTT DMPA26U MA Inhibitor DMPA26U RN Tyrosinase inhibitors: a patent review (2011-2015).Expert Opin Ther Pat. 2016;26(3):347-62. DMPA26U RU https://www.ncbi.nlm.nih.gov/pubmed/26815044 DMGDLPZ DI DMGDLPZ DMGDLPZ DN Resorcinol compound 11 DMGDLPZ MI TTULVH8 DMGDLPZ MN Tyrosinase (TYR) DMGDLPZ MT DTT DMGDLPZ MA Inhibitor DMGDLPZ RN Tyrosinase inhibitors: a patent review (2011-2015).Expert Opin Ther Pat. 2016;26(3):347-62. DMGDLPZ RU https://www.ncbi.nlm.nih.gov/pubmed/26815044 DMEMT3I DI DMEMT3I DMEMT3I DN Resorcinol compound 12 DMEMT3I MI TTULVH8 DMEMT3I MN Tyrosinase (TYR) DMEMT3I MT DTT DMEMT3I MA Inhibitor DMEMT3I RN Tyrosinase inhibitors: a patent review (2011-2015).Expert Opin Ther Pat. 2016;26(3):347-62. DMEMT3I RU https://www.ncbi.nlm.nih.gov/pubmed/26815044 DMVARUE DI DMVARUE DMVARUE DN Resorcinol compound 13 DMVARUE MI TTULVH8 DMVARUE MN Tyrosinase (TYR) DMVARUE MT DTT DMVARUE MA Inhibitor DMVARUE RN Tyrosinase inhibitors: a patent review (2011-2015).Expert Opin Ther Pat. 2016;26(3):347-62. DMVARUE RU https://www.ncbi.nlm.nih.gov/pubmed/26815044 DM6XFA5 DI DM6XFA5 DM6XFA5 DN Resorcinol compound 14 DM6XFA5 MI TTULVH8 DM6XFA5 MN Tyrosinase (TYR) DM6XFA5 MT DTT DM6XFA5 MA Inhibitor DM6XFA5 RN Tyrosinase inhibitors: a patent review (2011-2015).Expert Opin Ther Pat. 2016;26(3):347-62. DM6XFA5 RU https://www.ncbi.nlm.nih.gov/pubmed/26815044 DMSLYVT DI DMSLYVT DMSLYVT DN Resorcinol compound 15 DMSLYVT MI TTULVH8 DMSLYVT MN Tyrosinase (TYR) DMSLYVT MT DTT DMSLYVT MA Inhibitor DMSLYVT RN Tyrosinase inhibitors: a patent review (2011-2015).Expert Opin Ther Pat. 2016;26(3):347-62. DMSLYVT RU https://www.ncbi.nlm.nih.gov/pubmed/26815044 DMFDXBJ DI DMFDXBJ DMFDXBJ DN Resorcinol compound 16 DMFDXBJ MI TTULVH8 DMFDXBJ MN Tyrosinase (TYR) DMFDXBJ MT DTT DMFDXBJ MA Inhibitor DMFDXBJ RN Tyrosinase inhibitors: a patent review (2011-2015).Expert Opin Ther Pat. 2016;26(3):347-62. DMFDXBJ RU https://www.ncbi.nlm.nih.gov/pubmed/26815044 DMFR4S0 DI DMFR4S0 DMFR4S0 DN Resorcinol compound 17 DMFR4S0 MI TTULVH8 DMFR4S0 MN Tyrosinase (TYR) DMFR4S0 MT DTT DMFR4S0 MA Inhibitor DMFR4S0 RN Tyrosinase inhibitors: a patent review (2011-2015).Expert Opin Ther Pat. 2016;26(3):347-62. DMFR4S0 RU https://www.ncbi.nlm.nih.gov/pubmed/26815044 DM64R2K DI DM64R2K DM64R2K DN Resorcinol compound 18 DM64R2K MI TTULVH8 DM64R2K MN Tyrosinase (TYR) DM64R2K MT DTT DM64R2K MA Inhibitor DM64R2K RN Tyrosinase inhibitors: a patent review (2011-2015).Expert Opin Ther Pat. 2016;26(3):347-62. DM64R2K RU https://www.ncbi.nlm.nih.gov/pubmed/26815044 DMJIZPQ DI DMJIZPQ DMJIZPQ DN Resorcinol compound 19 DMJIZPQ MI TTULVH8 DMJIZPQ MN Tyrosinase (TYR) DMJIZPQ MT DTT DMJIZPQ MA Inhibitor DMJIZPQ RN Tyrosinase inhibitors: a patent review (2011-2015).Expert Opin Ther Pat. 2016;26(3):347-62. DMJIZPQ RU https://www.ncbi.nlm.nih.gov/pubmed/26815044 DMGDQYW DI DMGDQYW DMGDQYW DN Resorcinol compound 2 DMGDQYW MI TTULVH8 DMGDQYW MN Tyrosinase (TYR) DMGDQYW MT DTT DMGDQYW MA Inhibitor DMGDQYW RN Tyrosinase inhibitors: a patent review (2011-2015).Expert Opin Ther Pat. 2016;26(3):347-62. DMGDQYW RU https://www.ncbi.nlm.nih.gov/pubmed/26815044 DME4OGJ DI DME4OGJ DME4OGJ DN Resorcinol compound 20 DME4OGJ MI TTULVH8 DME4OGJ MN Tyrosinase (TYR) DME4OGJ MT DTT DME4OGJ MA Inhibitor DME4OGJ RN Tyrosinase inhibitors: a patent review (2011-2015).Expert Opin Ther Pat. 2016;26(3):347-62. DME4OGJ RU https://www.ncbi.nlm.nih.gov/pubmed/26815044 DM8EQPJ DI DM8EQPJ DM8EQPJ DN Resorcinol compound 21 DM8EQPJ MI TTULVH8 DM8EQPJ MN Tyrosinase (TYR) DM8EQPJ MT DTT DM8EQPJ MA Inhibitor DM8EQPJ RN Tyrosinase inhibitors: a patent review (2011-2015).Expert Opin Ther Pat. 2016;26(3):347-62. DM8EQPJ RU https://www.ncbi.nlm.nih.gov/pubmed/26815044 DMSW3GB DI DMSW3GB DMSW3GB DN Resorcinol compound 22 DMSW3GB MI TTULVH8 DMSW3GB MN Tyrosinase (TYR) DMSW3GB MT DTT DMSW3GB MA Inhibitor DMSW3GB RN Tyrosinase inhibitors: a patent review (2011-2015).Expert Opin Ther Pat. 2016;26(3):347-62. DMSW3GB RU https://www.ncbi.nlm.nih.gov/pubmed/26815044 DMU3APC DI DMU3APC DMU3APC DN Resorcinol compound 23 DMU3APC MI TTULVH8 DMU3APC MN Tyrosinase (TYR) DMU3APC MT DTT DMU3APC MA Inhibitor DMU3APC RN Tyrosinase inhibitors: a patent review (2011-2015).Expert Opin Ther Pat. 2016;26(3):347-62. DMU3APC RU https://www.ncbi.nlm.nih.gov/pubmed/26815044 DM2IKDL DI DM2IKDL DM2IKDL DN Resorcinol compound 24 DM2IKDL MI TTULVH8 DM2IKDL MN Tyrosinase (TYR) DM2IKDL MT DTT DM2IKDL MA Inhibitor DM2IKDL RN Tyrosinase inhibitors: a patent review (2011-2015).Expert Opin Ther Pat. 2016;26(3):347-62. DM2IKDL RU https://www.ncbi.nlm.nih.gov/pubmed/26815044 DMEZUN7 DI DMEZUN7 DMEZUN7 DN Resorcinol compound 25 DMEZUN7 MI TTULVH8 DMEZUN7 MN Tyrosinase (TYR) DMEZUN7 MT DTT DMEZUN7 MA Inhibitor DMEZUN7 RN Tyrosinase inhibitors: a patent review (2011-2015).Expert Opin Ther Pat. 2016;26(3):347-62. DMEZUN7 RU https://www.ncbi.nlm.nih.gov/pubmed/26815044 DMT21JG DI DMT21JG DMT21JG DN Resorcinol compound 26 DMT21JG MI TTULVH8 DMT21JG MN Tyrosinase (TYR) DMT21JG MT DTT DMT21JG MA Inhibitor DMT21JG RN Tyrosinase inhibitors: a patent review (2011-2015).Expert Opin Ther Pat. 2016;26(3):347-62. DMT21JG RU https://www.ncbi.nlm.nih.gov/pubmed/26815044 DM71R3T DI DM71R3T DM71R3T DN Resorcinol compound 27 DM71R3T MI TTULVH8 DM71R3T MN Tyrosinase (TYR) DM71R3T MT DTT DM71R3T MA Inhibitor DM71R3T RN Tyrosinase inhibitors: a patent review (2011-2015).Expert Opin Ther Pat. 2016;26(3):347-62. DM71R3T RU https://www.ncbi.nlm.nih.gov/pubmed/26815044 DMCHLAN DI DMCHLAN DMCHLAN DN Resorcinol compound 28 DMCHLAN MI TTULVH8 DMCHLAN MN Tyrosinase (TYR) DMCHLAN MT DTT DMCHLAN MA Inhibitor DMCHLAN RN Tyrosinase inhibitors: a patent review (2011-2015).Expert Opin Ther Pat. 2016;26(3):347-62. DMCHLAN RU https://www.ncbi.nlm.nih.gov/pubmed/26815044 DML7ONU DI DML7ONU DML7ONU DN Resorcinol compound 29 DML7ONU MI TTULVH8 DML7ONU MN Tyrosinase (TYR) DML7ONU MT DTT DML7ONU MA Inhibitor DML7ONU RN Tyrosinase inhibitors: a patent review (2011-2015).Expert Opin Ther Pat. 2016;26(3):347-62. DML7ONU RU https://www.ncbi.nlm.nih.gov/pubmed/26815044 DMPTK0G DI DMPTK0G DMPTK0G DN Resorcinol compound 3 DMPTK0G MI TTULVH8 DMPTK0G MN Tyrosinase (TYR) DMPTK0G MT DTT DMPTK0G MA Inhibitor DMPTK0G RN Tyrosinase inhibitors: a patent review (2011-2015).Expert Opin Ther Pat. 2016;26(3):347-62. DMPTK0G RU https://www.ncbi.nlm.nih.gov/pubmed/26815044 DMMTVN4 DI DMMTVN4 DMMTVN4 DN Resorcinol compound 30 DMMTVN4 MI TTULVH8 DMMTVN4 MN Tyrosinase (TYR) DMMTVN4 MT DTT DMMTVN4 MA Inhibitor DMMTVN4 RN Tyrosinase inhibitors: a patent review (2011-2015).Expert Opin Ther Pat. 2016;26(3):347-62. DMMTVN4 RU https://www.ncbi.nlm.nih.gov/pubmed/26815044 DMSPCLD DI DMSPCLD DMSPCLD DN Resorcinol compound 31 DMSPCLD MI TTULVH8 DMSPCLD MN Tyrosinase (TYR) DMSPCLD MT DTT DMSPCLD MA Inhibitor DMSPCLD RN Tyrosinase inhibitors: a patent review (2011-2015).Expert Opin Ther Pat. 2016;26(3):347-62. DMSPCLD RU https://www.ncbi.nlm.nih.gov/pubmed/26815044 DM2RPYB DI DM2RPYB DM2RPYB DN Resorcinol compound 32 DM2RPYB MI TTULVH8 DM2RPYB MN Tyrosinase (TYR) DM2RPYB MT DTT DM2RPYB MA Inhibitor DM2RPYB RN Tyrosinase inhibitors: a patent review (2011-2015).Expert Opin Ther Pat. 2016;26(3):347-62. DM2RPYB RU https://www.ncbi.nlm.nih.gov/pubmed/26815044 DMLJYS1 DI DMLJYS1 DMLJYS1 DN Resorcinol compound 33 DMLJYS1 MI TTULVH8 DMLJYS1 MN Tyrosinase (TYR) DMLJYS1 MT DTT DMLJYS1 MA Inhibitor DMLJYS1 RN Tyrosinase inhibitors: a patent review (2011-2015).Expert Opin Ther Pat. 2016;26(3):347-62. DMLJYS1 RU https://www.ncbi.nlm.nih.gov/pubmed/26815044 DMQF90E DI DMQF90E DMQF90E DN Resorcinol compound 34 DMQF90E MI TTULVH8 DMQF90E MN Tyrosinase (TYR) DMQF90E MT DTT DMQF90E MA Inhibitor DMQF90E RN Tyrosinase inhibitors: a patent review (2011-2015).Expert Opin Ther Pat. 2016;26(3):347-62. DMQF90E RU https://www.ncbi.nlm.nih.gov/pubmed/26815044 DMIM9EY DI DMIM9EY DMIM9EY DN Resorcinol compound 4 DMIM9EY MI TTULVH8 DMIM9EY MN Tyrosinase (TYR) DMIM9EY MT DTT DMIM9EY MA Inhibitor DMIM9EY RN Tyrosinase inhibitors: a patent review (2011-2015).Expert Opin Ther Pat. 2016;26(3):347-62. DMIM9EY RU https://www.ncbi.nlm.nih.gov/pubmed/26815044 DMQ5TYK DI DMQ5TYK DMQ5TYK DN Resorcinol compound 5 DMQ5TYK MI TTULVH8 DMQ5TYK MN Tyrosinase (TYR) DMQ5TYK MT DTT DMQ5TYK MA Inhibitor DMQ5TYK RN Tyrosinase inhibitors: a patent review (2011-2015).Expert Opin Ther Pat. 2016;26(3):347-62. DMQ5TYK RU https://www.ncbi.nlm.nih.gov/pubmed/26815044 DM809YH DI DM809YH DM809YH DN Resorcinol compound 6 DM809YH MI TTULVH8 DM809YH MN Tyrosinase (TYR) DM809YH MT DTT DM809YH MA Inhibitor DM809YH RN Tyrosinase inhibitors: a patent review (2011-2015).Expert Opin Ther Pat. 2016;26(3):347-62. DM809YH RU https://www.ncbi.nlm.nih.gov/pubmed/26815044 DM031RU DI DM031RU DM031RU DN Resorcinol compound 7 DM031RU MI TTULVH8 DM031RU MN Tyrosinase (TYR) DM031RU MT DTT DM031RU MA Inhibitor DM031RU RN Tyrosinase inhibitors: a patent review (2011-2015).Expert Opin Ther Pat. 2016;26(3):347-62. DM031RU RU https://www.ncbi.nlm.nih.gov/pubmed/26815044 DMLF53V DI DMLF53V DMLF53V DN Resorcinol compound 8 DMLF53V MI TTULVH8 DMLF53V MN Tyrosinase (TYR) DMLF53V MT DTT DMLF53V MA Inhibitor DMLF53V RN Tyrosinase inhibitors: a patent review (2011-2015).Expert Opin Ther Pat. 2016;26(3):347-62. DMLF53V RU https://www.ncbi.nlm.nih.gov/pubmed/26815044 DMCJO0R DI DMCJO0R DMCJO0R DN Resorcinol compound 9 DMCJO0R MI TTULVH8 DMCJO0R MN Tyrosinase (TYR) DMCJO0R MT DTT DMCJO0R MA Inhibitor DMCJO0R RN Tyrosinase inhibitors: a patent review (2011-2015).Expert Opin Ther Pat. 2016;26(3):347-62. DMCJO0R RU https://www.ncbi.nlm.nih.gov/pubmed/26815044 DMUB7RV DI DMUB7RV DMUB7RV DN Ring-fused compound 1 DMUB7RV MI TTA592U DMUB7RV MN Urate anion exchanger 1 (URAT1) DMUB7RV MT DTT DMUB7RV MA Inhibitor DMUB7RV RN Urate transporter URAT1 inhibitors: a patent review (2012 - 2015).Expert Opin Ther Pat. 2016 Jul 30:1-10. DMUB7RV RU https://www.ncbi.nlm.nih.gov/pubmed/27414413 DMD1G3Z DI DMD1G3Z DMD1G3Z DN Roscovitine derivative 1 DMD1G3Z MI TTH6V3D DMD1G3Z MN Cyclin-dependent kinase 1 (CDK1) DMD1G3Z MT DTT DMD1G3Z MA Inhibitor DMD1G3Z RN Cyclin-dependent kinase inhibitors for cancer therapy: a patent review (2009 - 2014).Expert Opin Ther Pat. 2015;25(9):953-70. DMD1G3Z RU https://www.ncbi.nlm.nih.gov/pubmed/26161698 DMD1G3Z DI DMD1G3Z DMD1G3Z DN Roscovitine derivative 1 DMD1G3Z MI TT7HF4W DMD1G3Z MN Cyclin-dependent kinase 2 (CDK2) DMD1G3Z MT DTT DMD1G3Z MA Inhibitor DMD1G3Z RN Cyclin-dependent kinase inhibitors for cancer therapy: a patent review (2009 - 2014).Expert Opin Ther Pat. 2015;25(9):953-70. DMD1G3Z RU https://www.ncbi.nlm.nih.gov/pubmed/26161698 DMD1G3Z DI DMD1G3Z DMD1G3Z DN Roscovitine derivative 1 DMD1G3Z MI TTL4Q97 DMD1G3Z MN Cyclin-dependent kinase 5 (CDK5) DMD1G3Z MT DTT DMD1G3Z MA Inhibitor DMD1G3Z RN Cyclin-dependent kinase inhibitors for cancer therapy: a patent review (2009 - 2014).Expert Opin Ther Pat. 2015;25(9):953-70. DMD1G3Z RU https://www.ncbi.nlm.nih.gov/pubmed/26161698 DMD1G3Z DI DMD1G3Z DMD1G3Z DN Roscovitine derivative 1 DMD1G3Z MI TTQYF7G DMD1G3Z MN Cyclin-dependent kinase 7 (CDK7) DMD1G3Z MT DTT DMD1G3Z MA Inhibitor DMD1G3Z RN Cyclin-dependent kinase inhibitors for cancer therapy: a patent review (2009 - 2014).Expert Opin Ther Pat. 2015;25(9):953-70. DMD1G3Z RU https://www.ncbi.nlm.nih.gov/pubmed/26161698 DMD1G3Z DI DMD1G3Z DMD1G3Z DN Roscovitine derivative 1 DMD1G3Z MI TT1LVF2 DMD1G3Z MN Cyclin-dependent kinase 9 (CDK9) DMD1G3Z MT DTT DMD1G3Z MA Inhibitor DMD1G3Z RN Cyclin-dependent kinase inhibitors for cancer therapy: a patent review (2009 - 2014).Expert Opin Ther Pat. 2015;25(9):953-70. DMD1G3Z RU https://www.ncbi.nlm.nih.gov/pubmed/26161698 DM41ZW9 DI DM41ZW9 DM41ZW9 DN Ruxolitinib derivative 1 DM41ZW9 MI TTJSQEF DM41ZW9 MN Tyrosine-protein kinase (PTK) DM41ZW9 MT DTT DM41ZW9 MA Inhibitor DM41ZW9 RN Inhibitors of JAK-family kinases: an update on the patent literature 2013-2015, part 1.Expert Opin Ther Pat. 2017 Feb;27(2):127-143. DM41ZW9 RU https://www.ncbi.nlm.nih.gov/pubmed/27774824 DMSJWZ3 DI DMSJWZ3 DMSJWZ3 DN Ruxolitinib derivative 2 DMSJWZ3 MI TT6DM01 DMSJWZ3 MN Janus kinase 1 (JAK-1) DMSJWZ3 MT DTT DMSJWZ3 MA Inhibitor DMSJWZ3 RN Inhibitors of JAK-family kinases: an update on the patent literature 2013-2015, part 1.Expert Opin Ther Pat. 2017 Feb;27(2):127-143. DMSJWZ3 RU https://www.ncbi.nlm.nih.gov/pubmed/27774824 DMSJWZ3 DI DMSJWZ3 DMSJWZ3 DN Ruxolitinib derivative 2 DMSJWZ3 MI TTRMX3V DMSJWZ3 MN Janus kinase 2 (JAK-2) DMSJWZ3 MT DTT DMSJWZ3 MA Inhibitor DMSJWZ3 RN Inhibitors of JAK-family kinases: an update on the patent literature 2013-2015, part 1.Expert Opin Ther Pat. 2017 Feb;27(2):127-143. DMSJWZ3 RU https://www.ncbi.nlm.nih.gov/pubmed/27774824 DMSJWZ3 DI DMSJWZ3 DMSJWZ3 DN Ruxolitinib derivative 2 DMSJWZ3 MI TTT7PJU DMSJWZ3 MN Janus kinase 3 (JAK-3) DMSJWZ3 MT DTT DMSJWZ3 MA Inhibitor DMSJWZ3 RN Inhibitors of JAK-family kinases: an update on the patent literature 2013-2015, part 1.Expert Opin Ther Pat. 2017 Feb;27(2):127-143. DMSJWZ3 RU https://www.ncbi.nlm.nih.gov/pubmed/27774824 DMB79QJ DI DMB79QJ DMB79QJ DN Salicylic acid derivative 1 DMB79QJ MI TTH8FZW DMB79QJ MN Signal transducer and activator of transcription 3 (STAT3) DMB79QJ MT DTT DMB79QJ MA Inhibitor DMB79QJ RN A STAT inhibitor patent review: progress since 2011.Expert Opin Ther Pat. 2015;25(12):1397-421. DMB79QJ RU https://www.ncbi.nlm.nih.gov/pubmed/26394986 DMD8C9S DI DMD8C9S DMD8C9S DN Salicylic acid derivative 2 DMD8C9S MI TTH8FZW DMD8C9S MN Signal transducer and activator of transcription 3 (STAT3) DMD8C9S MT DTT DMD8C9S MA Inhibitor DMD8C9S RN A STAT inhibitor patent review: progress since 2011.Expert Opin Ther Pat. 2015;25(12):1397-421. DMD8C9S RU https://www.ncbi.nlm.nih.gov/pubmed/26394986 DM4OGKH DI DM4OGKH DM4OGKH DN Salicylic acid derivative 3 DM4OGKH MI TTH8FZW DM4OGKH MN Signal transducer and activator of transcription 3 (STAT3) DM4OGKH MT DTT DM4OGKH MA Inhibitor DM4OGKH RN A STAT inhibitor patent review: progress since 2011.Expert Opin Ther Pat. 2015;25(12):1397-421. DM4OGKH RU https://www.ncbi.nlm.nih.gov/pubmed/26394986 DM4MAHK DI DM4MAHK DM4MAHK DN Salicylic acid derivative 4 DM4MAHK MI TTH8FZW DM4MAHK MN Signal transducer and activator of transcription 3 (STAT3) DM4MAHK MT DTT DM4MAHK MA Inhibitor DM4MAHK RN A STAT inhibitor patent review: progress since 2011.Expert Opin Ther Pat. 2015;25(12):1397-421. DM4MAHK RU https://www.ncbi.nlm.nih.gov/pubmed/26394986 DM3OZ0F DI DM3OZ0F DM3OZ0F DN Salicylic acid derivative 5 DM3OZ0F MI TTH8FZW DM3OZ0F MN Signal transducer and activator of transcription 3 (STAT3) DM3OZ0F MT DTT DM3OZ0F MA Inhibitor DM3OZ0F RN A STAT inhibitor patent review: progress since 2011.Expert Opin Ther Pat. 2015;25(12):1397-421. DM3OZ0F RU https://www.ncbi.nlm.nih.gov/pubmed/26394986 DMLBEPW DI DMLBEPW DMLBEPW DN Salicylic acid derivative 6 DMLBEPW MI TTH8FZW DMLBEPW MN Signal transducer and activator of transcription 3 (STAT3) DMLBEPW MT DTT DMLBEPW MA Inhibitor DMLBEPW RN A STAT inhibitor patent review: progress since 2011.Expert Opin Ther Pat. 2015;25(12):1397-421. DMLBEPW RU https://www.ncbi.nlm.nih.gov/pubmed/26394986 DMJFHVN DI DMJFHVN DMJFHVN DN Salicylic acid derivative 7 DMJFHVN MI TTH8FZW DMJFHVN MN Signal transducer and activator of transcription 3 (STAT3) DMJFHVN MT DTT DMJFHVN MA Inhibitor DMJFHVN RN A STAT inhibitor patent review: progress since 2011.Expert Opin Ther Pat. 2015;25(12):1397-421. DMJFHVN RU https://www.ncbi.nlm.nih.gov/pubmed/26394986 DM2MQD0 DI DM2MQD0 DM2MQD0 DN SB19065 DM2MQD0 MI TT42OGM DM2MQD0 MN Hematopoietic cell kinase (HCK) DM2MQD0 MT DTT DM2MQD0 MA Inhibitor DM2MQD0 RN Anti-inflammatory compound having inhibitory activity against multiple tyrosine kinases and pharmaceutical composition containing same. US9062066. DM2MQD0 RU http://www.freepatentsonline.com/US9062066.html DMKQ0GE DI DMKQ0GE DMKQ0GE DN SCHEMBL15198145 DMKQ0GE MI TTXHWA7 DMKQ0GE MN Ubiquitin-activating enzyme E1 (UBAE1) DMKQ0GE MT DTT DMKQ0GE MA Inhibitor DMKQ0GE RN Pyrazolopyrimidinyl inhibitors of ubiquitin-activating enzyme. US10202389. DMKQ0GE RU http://www.freepatentsonline.com/US10202389.html DMHPQI2 DI DMHPQI2 DMHPQI2 DN SCHEMBL15198146 DMHPQI2 MI TTXHWA7 DMHPQI2 MN Ubiquitin-activating enzyme E1 (UBAE1) DMHPQI2 MT DTT DMHPQI2 MA Inhibitor DMHPQI2 RN Pyrazolopyrimidinyl inhibitors of ubiquitin-activating enzyme. US10202389. DMHPQI2 RU http://www.freepatentsonline.com/US10202389.html DMK0T9E DI DMK0T9E DMK0T9E DN SCHEMBL15295829 DMK0T9E MI TTVSMOH DMK0T9E MN Sphingosine-1-phosphate receptor 2 (S1PR2) DMK0T9E MT DTT DMK0T9E MA Inhibitor DMK0T9E RN Sphingosine 1-phosphate receptor antagonists. US9663511. DMK0T9E RU http://www.freepatentsonline.com/US9663511.html DM3OB4T DI DM3OB4T DM3OB4T DN SCHEMBL16322760 DM3OB4T MI TT78309 DM3OB4T MN BUB1 mitotic checkpoint serine/threonine kinase (BUB1) DM3OB4T MT DTT DM3OB4T MA Inhibitor DM3OB4T RN Substituted benzylpyrazoles. US9765058. DM3OB4T RU http://www.freepatentsonline.com/US9765058.html DMQARW2 DI DMQARW2 DMQARW2 DN SCHEMBL16365841 DMQARW2 MI TT78309 DMQARW2 MN BUB1 mitotic checkpoint serine/threonine kinase (BUB1) DMQARW2 MT DTT DMQARW2 MA Inhibitor DMQARW2 RN Substituted benzylpyrazoles. US9765058. DMQARW2 RU http://www.freepatentsonline.com/US9765058.html DMC7PTY DI DMC7PTY DMC7PTY DN SCHEMBL17766424 DMC7PTY MI TT78309 DMC7PTY MN BUB1 mitotic checkpoint serine/threonine kinase (BUB1) DMC7PTY MT DTT DMC7PTY MA Inhibitor DMC7PTY RN Substituted benzylpyrazoles. US9765058. DMC7PTY RU http://www.freepatentsonline.com/US9765058.html DMQD6IL DI DMQD6IL DMQD6IL DN Schiff base compound 1 DMQD6IL MI TT3WG5C DMQD6IL MN Monoamine oxidase type A (MAO-A) DMQD6IL MT DTT DMQD6IL RN MAO inhibitors and their wider applications: a patent review.Expert Opin Ther Pat. 2018 Mar;28(3):211-226. DMQD6IL RU https://www.ncbi.nlm.nih.gov/pubmed/29324067 DMQD6IL DI DMQD6IL DMQD6IL DN Schiff base compound 1 DMQD6IL MI TTGP7BY DMQD6IL MN Monoamine oxidase type B (MAO-B) DMQD6IL MT DTT DMQD6IL RN MAO inhibitors and their wider applications: a patent review.Expert Opin Ther Pat. 2018 Mar;28(3):211-226. DMQD6IL RU https://www.ncbi.nlm.nih.gov/pubmed/29324067 DMWD20L DI DMWD20L DMWD20L DN Schiff base compound 2 DMWD20L MI TTGP7BY DMWD20L MN Monoamine oxidase type B (MAO-B) DMWD20L MT DTT DMWD20L RN MAO inhibitors and their wider applications: a patent review.Expert Opin Ther Pat. 2018 Mar;28(3):211-226. DMWD20L RU https://www.ncbi.nlm.nih.gov/pubmed/29324067 DMEDNTJ DI DMEDNTJ DMEDNTJ DN Secondary and tertiary (hetero)arylamide derivative 1 DMEDNTJ MI TTGP7BY DMEDNTJ MN Monoamine oxidase type B (MAO-B) DMEDNTJ MT DTT DMEDNTJ MA Inhibitor DMEDNTJ RN MAO inhibitors and their wider applications: a patent review.Expert Opin Ther Pat. 2018 Mar;28(3):211-226. DMEDNTJ RU https://www.ncbi.nlm.nih.gov/pubmed/29324067 DMIES9B DI DMIES9B DMIES9B DN Secondary and tertiary (hetero)arylamide derivative 2 DMIES9B MI TT3WG5C DMIES9B MN Monoamine oxidase type A (MAO-A) DMIES9B MT DTT DMIES9B MA Inhibitor DMIES9B RN MAO inhibitors and their wider applications: a patent review.Expert Opin Ther Pat. 2018 Mar;28(3):211-226. DMIES9B RU https://www.ncbi.nlm.nih.gov/pubmed/29324067 DM9C5Z8 DI DM9C5Z8 DM9C5Z8 DN Selenium compound 1 DM9C5Z8 MI TTZHPB8 DM9C5Z8 MN Lysine-specific demethylase 4A (KDM4A) DM9C5Z8 MT DTT DM9C5Z8 MA Inhibitor DM9C5Z8 RN KDM4 histone demethylase inhibitors for anti-cancer agents: a patent review.Expert Opin Ther Pat. 2015 Feb;25(2):135-44. DM9C5Z8 RU https://www.ncbi.nlm.nih.gov/pubmed/25468267 DMLWIJ7 DI DMLWIJ7 DMLWIJ7 DN Selenium compound 2 DMLWIJ7 MI TTZHPB8 DMLWIJ7 MN Lysine-specific demethylase 4A (KDM4A) DMLWIJ7 MT DTT DMLWIJ7 MA Inhibitor DMLWIJ7 RN KDM4 histone demethylase inhibitors for anti-cancer agents: a patent review.Expert Opin Ther Pat. 2015 Feb;25(2):135-44. DMLWIJ7 RU https://www.ncbi.nlm.nih.gov/pubmed/25468267 DMQ5AJ6 DI DMQ5AJ6 DMQ5AJ6 DN Selenium compound 3 DMQ5AJ6 MI TTZHPB8 DMQ5AJ6 MN Lysine-specific demethylase 4A (KDM4A) DMQ5AJ6 MT DTT DMQ5AJ6 MA Inhibitor DMQ5AJ6 RN KDM4 histone demethylase inhibitors for anti-cancer agents: a patent review.Expert Opin Ther Pat. 2015 Feb;25(2):135-44. DMQ5AJ6 RU https://www.ncbi.nlm.nih.gov/pubmed/25468267 DMYFK85 DI DMYFK85 DMYFK85 DN Six-membered heterocyclic benzamide derivative 1 DMYFK85 MI TTTDVOJ DMYFK85 MN Tropomyosin-related kinase A (TrkA) DMYFK85 MT DTT DMYFK85 MA Inhibitor DMYFK85 RN Tropomyosin receptor kinase inhibitors: an updated patent review for 2010-2016 - Part II.Expert Opin Ther Pat. 2017 Jul;27(7):831-849. DMYFK85 RU https://www.ncbi.nlm.nih.gov/pubmed/28270021 DMX6AKV DI DMX6AKV DMX6AKV DN Six-membered heterocyclic benzamide derivative 2 DMX6AKV MI TTTDVOJ DMX6AKV MN Tropomyosin-related kinase A (TrkA) DMX6AKV MT DTT DMX6AKV MA Inhibitor DMX6AKV RN Tropomyosin receptor kinase inhibitors: an updated patent review for 2010-2016 - Part II.Expert Opin Ther Pat. 2017 Jul;27(7):831-849. DMX6AKV RU https://www.ncbi.nlm.nih.gov/pubmed/28270021 DMEGVD4 DI DMEGVD4 DMEGVD4 DN Six-membered heterocyclic benzamide derivative 3 DMEGVD4 MI TTTDVOJ DMEGVD4 MN Tropomyosin-related kinase A (TrkA) DMEGVD4 MT DTT DMEGVD4 MA Inhibitor DMEGVD4 RN Tropomyosin receptor kinase inhibitors: an updated patent review for 2010-2016 - Part II.Expert Opin Ther Pat. 2017 Jul;27(7):831-849. DMEGVD4 RU https://www.ncbi.nlm.nih.gov/pubmed/28270021 DMB0D1H DI DMB0D1H DMB0D1H DN Six-membered heterocyclic benzamide derivative 4 DMB0D1H MI TTTDVOJ DMB0D1H MN Tropomyosin-related kinase A (TrkA) DMB0D1H MT DTT DMB0D1H MA Inhibitor DMB0D1H RN Tropomyosin receptor kinase inhibitors: an updated patent review for 2010-2016 - Part II.Expert Opin Ther Pat. 2017 Jul;27(7):831-849. DMB0D1H RU https://www.ncbi.nlm.nih.gov/pubmed/28270021 DM0GTUH DI DM0GTUH DM0GTUH DN Six-membered heterocyclic benzamide derivative 5 DM0GTUH MI TTTDVOJ DM0GTUH MN Tropomyosin-related kinase A (TrkA) DM0GTUH MT DTT DM0GTUH MA Inhibitor DM0GTUH RN Tropomyosin receptor kinase inhibitors: an updated patent review for 2010-2016 - Part II.Expert Opin Ther Pat. 2017 Jul;27(7):831-849. DM0GTUH RU https://www.ncbi.nlm.nih.gov/pubmed/28270021 DMZU96C DI DMZU96C DMZU96C DN Six-membered heterocyclic benzamide derivative 6 DMZU96C MI TTTDVOJ DMZU96C MN Tropomyosin-related kinase A (TrkA) DMZU96C MT DTT DMZU96C MA Inhibitor DMZU96C RN Tropomyosin receptor kinase inhibitors: an updated patent review for 2010-2016 - Part II.Expert Opin Ther Pat. 2017 Jul;27(7):831-849. DMZU96C RU https://www.ncbi.nlm.nih.gov/pubmed/28270021 DM15AFI DI DM15AFI DM15AFI DN Six-membered heterocyclic benzamide derivative 7 DM15AFI MI TTTDVOJ DM15AFI MN Tropomyosin-related kinase A (TrkA) DM15AFI MT DTT DM15AFI MA Inhibitor DM15AFI RN Tropomyosin receptor kinase inhibitors: an updated patent review for 2010-2016 - Part II.Expert Opin Ther Pat. 2017 Jul;27(7):831-849. DM15AFI RU https://www.ncbi.nlm.nih.gov/pubmed/28270021 DMJF6S0 DI DMJF6S0 DMJF6S0 DN Sphinx DMJF6S0 MI TTU3WV6 DMJF6S0 MN SRSF protein kinase 1 (SRPK1) DMJF6S0 MT DTT DMJF6S0 MA Inhibitor DMJF6S0 RN Piperazine derivatives for treating disorders. US9695160. DMJF6S0 RU http://www.freepatentsonline.com/US9695160.html DM8XJTH DI DM8XJTH DM8XJTH DN SPHINX scaffold, 3 DM8XJTH MI TTU3WV6 DM8XJTH MN SRSF protein kinase 1 (SRPK1) DM8XJTH MT DTT DM8XJTH MA Inhibitor DM8XJTH RN Piperazine derivatives for treating disorders. US9695160. DM8XJTH RU http://www.freepatentsonline.com/US9695160.html DM4R7OQ DI DM4R7OQ DM4R7OQ DN Spirocyclic diamine urea derivative 1 DM4R7OQ MI TTDP1UC DM4R7OQ MN Fatty acid amide hydrolase (FAAH) DM4R7OQ MT DTT DM4R7OQ MA Inhibitor DM4R7OQ RN Fatty acid amide hydrolase inhibitors: a patent review (2009-2014).Expert Opin Ther Pat. 2015;25(11):1247-66. DM4R7OQ RU https://www.ncbi.nlm.nih.gov/pubmed/26413912 DMH5N78 DI DMH5N78 DMH5N78 DN Spirocyclic diamine urea derivative 2 DMH5N78 MI TTDP1UC DMH5N78 MN Fatty acid amide hydrolase (FAAH) DMH5N78 MT DTT DMH5N78 MA Inhibitor DMH5N78 RN Fatty acid amide hydrolase inhibitors: a patent review (2009-2014).Expert Opin Ther Pat. 2015;25(11):1247-66. DMH5N78 RU https://www.ncbi.nlm.nih.gov/pubmed/26413912 DMCPVRU DI DMCPVRU DMCPVRU DN Spiroimidazolone derivative 1 DMCPVRU MI TT9O6WS DMCPVRU MN Glucagon receptor (GCGR) DMCPVRU MT DTT DMCPVRU MA Antagonist DMCPVRU RN Small molecule glucagon receptor antagonists: a patent review (2011 - 2014).Expert Opin Ther Pat. 2015 Jul;25(7):819-30. DMCPVRU RU https://www.ncbi.nlm.nih.gov/pubmed/25828189 DM3EAHB DI DM3EAHB DM3EAHB DN Spiroimidazolone derivative 2 DM3EAHB MI TT9O6WS DM3EAHB MN Glucagon receptor (GCGR) DM3EAHB MT DTT DM3EAHB MA Antagonist DM3EAHB RN Small molecule glucagon receptor antagonists: a patent review (2011 - 2014).Expert Opin Ther Pat. 2015 Jul;25(7):819-30. DM3EAHB RU https://www.ncbi.nlm.nih.gov/pubmed/25828189 DM02J8N DI DM02J8N DM02J8N DN Spiroimidazolone derivative 3 DM02J8N MI TT9O6WS DM02J8N MN Glucagon receptor (GCGR) DM02J8N MT DTT DM02J8N MA Antagonist DM02J8N RN Small molecule glucagon receptor antagonists: a patent review (2011 - 2014).Expert Opin Ther Pat. 2015 Jul;25(7):819-30. DM02J8N RU https://www.ncbi.nlm.nih.gov/pubmed/25828189 DMXIHPT DI DMXIHPT DMXIHPT DN Spiroimidazolone derivative 4 DMXIHPT MI TT9O6WS DMXIHPT MN Glucagon receptor (GCGR) DMXIHPT MT DTT DMXIHPT MA Antagonist DMXIHPT RN Small molecule glucagon receptor antagonists: a patent review (2011 - 2014).Expert Opin Ther Pat. 2015 Jul;25(7):819-30. DMXIHPT RU https://www.ncbi.nlm.nih.gov/pubmed/25828189 DM5A62X DI DM5A62X DM5A62X DN Spiroimidazolone derivative 5 DM5A62X MI TT9O6WS DM5A62X MN Glucagon receptor (GCGR) DM5A62X MT DTT DM5A62X MA Antagonist DM5A62X RN Small molecule glucagon receptor antagonists: a patent review (2011 - 2014).Expert Opin Ther Pat. 2015 Jul;25(7):819-30. DM5A62X RU https://www.ncbi.nlm.nih.gov/pubmed/25828189 DMJN5CI DI DMJN5CI DMJN5CI DN Spiroimidazolone derivative 6 DMJN5CI MI TT9O6WS DMJN5CI MN Glucagon receptor (GCGR) DMJN5CI MT DTT DMJN5CI MA Antagonist DMJN5CI RN Small molecule glucagon receptor antagonists: a patent review (2011 - 2014).Expert Opin Ther Pat. 2015 Jul;25(7):819-30. DMJN5CI RU https://www.ncbi.nlm.nih.gov/pubmed/25828189 DM5A4TP DI DM5A4TP DM5A4TP DN Spiroimidazolone derivative 7 DM5A4TP MI TT9O6WS DM5A4TP MN Glucagon receptor (GCGR) DM5A4TP MT DTT DM5A4TP MA Antagonist DM5A4TP RN Small molecule glucagon receptor antagonists: a patent review (2011 - 2014).Expert Opin Ther Pat. 2015 Jul;25(7):819-30. DM5A4TP RU https://www.ncbi.nlm.nih.gov/pubmed/25828189 DMK5G7D DI DMK5G7D DMK5G7D DN Spirolaxine derivative 1 DMK5G7D MI TTZMAO3 DMK5G7D MN Peroxisome proliferator-activated receptor gamma (PPAR-gamma) DMK5G7D MT DTT DMK5G7D MA Agonist DMK5G7D RN PPAR ligands and their therapeutic applications: a patent review (2008 - 2014).Expert Opin Ther Pat. 2015 Feb;25(2):175-91. DMK5G7D RU https://www.ncbi.nlm.nih.gov/pubmed/25416646 DMYJL2Z DI DMYJL2Z DMYJL2Z DN Spiroquinolone derivative 1 DMYJL2Z MI TTRZQE3 DMYJL2Z MN Glycogen synthase kinase-3 alpha (GSK-3A) DMYJL2Z MT DTT DMYJL2Z MA Inhibitor DMYJL2Z RN Glycogen synthase kinase 3 (GSK-3) inhibitors: a patent update (2014-2015).Expert Opin Ther Pat. 2017 Jun;27(6):657-666. DMYJL2Z RU https://www.ncbi.nlm.nih.gov/pubmed/27828716 DMB0NVQ DI DMB0NVQ DMB0NVQ DN Steroid derivative 1 DMB0NVQ MI TTUX68I DMB0NVQ MN Hypoxia-inducible factor 1 (HIF-1) DMB0NVQ MT DTT DMB0NVQ MA Inhibitor DMB0NVQ RN Hypoxia-inducible factor (HIF) inhibitors: a patent survey (2011-2015).Expert Opin Ther Pat. 2016;26(3):309-22. DMB0NVQ RU https://www.ncbi.nlm.nih.gov/pubmed/26882240 DMQ0RGB DI DMQ0RGB DMQ0RGB DN Steroid derivative 2 DMQ0RGB MI TTUX68I DMQ0RGB MN Hypoxia-inducible factor 1 (HIF-1) DMQ0RGB MT DTT DMQ0RGB MA Inhibitor DMQ0RGB RN Hypoxia-inducible factor (HIF) inhibitors: a patent survey (2011-2015).Expert Opin Ther Pat. 2016;26(3):309-22. DMQ0RGB RU https://www.ncbi.nlm.nih.gov/pubmed/26882240 DMETIKC DI DMETIKC DMETIKC DN Steroid derivative 3 DMETIKC MI TTUX68I DMETIKC MN Hypoxia-inducible factor 1 (HIF-1) DMETIKC MT DTT DMETIKC MA Inhibitor DMETIKC RN Hypoxia-inducible factor (HIF) inhibitors: a patent survey (2011-2015).Expert Opin Ther Pat. 2016;26(3):309-22. DMETIKC RU https://www.ncbi.nlm.nih.gov/pubmed/26882240 DMJPYVS DI DMJPYVS DMJPYVS DN Steroid derivative 4 DMJPYVS MI TTUX68I DMJPYVS MN Hypoxia-inducible factor 1 (HIF-1) DMJPYVS MT DTT DMJPYVS MA Inhibitor DMJPYVS RN Hypoxia-inducible factor (HIF) inhibitors: a patent survey (2011-2015).Expert Opin Ther Pat. 2016;26(3):309-22. DMJPYVS RU https://www.ncbi.nlm.nih.gov/pubmed/26882240 DMHLA5V DI DMHLA5V DMHLA5V DN Steroidal carboxamide derivative 1 DMHLA5V MI TT9JNIC DMHLA5V MN Histamine H3 receptor (H3R) DMHLA5V MT DTT DMHLA5V RN Progress in the development of histamine H3 receptor antagonists/inverse agonists: a patent review (2013-2017).Expert Opin Ther Pat. 2018 Mar;28(3):175-196. DMHLA5V RU https://www.ncbi.nlm.nih.gov/pubmed/29334795 DM5U36G DI DM5U36G DM5U36G DN Sterol derivative 1 DM5U36G MI TTPADOQ DM5U36G MN HMG-CoA reductase (HMGCR) DM5U36G MT DTT DM5U36G MA Inhibitor DM5U36G RN HMG-CoA Reductase inhibitors: an updated review of patents of novel compounds and formulations (2011-2015).Expert Opin Ther Pat. 2016 Nov;26(11):1257-1272. DM5U36G RU https://www.ncbi.nlm.nih.gov/pubmed/27537201 DME1B23 DI DME1B23 DME1B23 DN Sterol derivative 2 DME1B23 MI TTPADOQ DME1B23 MN HMG-CoA reductase (HMGCR) DME1B23 MT DTT DME1B23 MA Inhibitor DME1B23 RN HMG-CoA Reductase inhibitors: an updated review of patents of novel compounds and formulations (2011-2015).Expert Opin Ther Pat. 2016 Nov;26(11):1257-1272. DME1B23 RU https://www.ncbi.nlm.nih.gov/pubmed/27537201 DMOT1FQ DI DMOT1FQ DMOT1FQ DN Sterol derivative 3 DMOT1FQ MI TTPADOQ DMOT1FQ MN HMG-CoA reductase (HMGCR) DMOT1FQ MT DTT DMOT1FQ MA Inhibitor DMOT1FQ RN HMG-CoA Reductase inhibitors: an updated review of patents of novel compounds and formulations (2011-2015).Expert Opin Ther Pat. 2016 Nov;26(11):1257-1272. DMOT1FQ RU https://www.ncbi.nlm.nih.gov/pubmed/27537201 DM6KPYL DI DM6KPYL DM6KPYL DN STK296197 DM6KPYL MI TT3RMNA DM6KPYL MN Chymotrypsin-C (CLCR) DM6KPYL MT DTT DM6KPYL MA Inhibitor DM6KPYL RN Benzoxazinone derivatives for treatment of skin diseases. US9695194. DM6KPYL RU http://www.freepatentsonline.com/US9695194.html DM19GAY DI DM19GAY DM19GAY DN STK696827 DM19GAY MI TT1NFO3 DM19GAY MN Bacterial Nicotinate-nucleotide adenylyltransferase (Bact nadD) DM19GAY MT DTT DM19GAY MA Inhibitor DM19GAY RN Targeting NAD biosynthesis in bacterial pathogens. US8785499. DM19GAY RU http://www.freepatentsonline.com/US8785499.html DMTXDSG DI DMTXDSG DMTXDSG DN Succinamide derivative 1 DMTXDSG MI TTA592U DMTXDSG MN Urate anion exchanger 1 (URAT1) DMTXDSG MT DTT DMTXDSG MA Inhibitor DMTXDSG RN Urate transporter URAT1 inhibitors: a patent review (2012 - 2015).Expert Opin Ther Pat. 2016 Jul 30:1-10. DMTXDSG RU https://www.ncbi.nlm.nih.gov/pubmed/27414413 DMQ0VK9 DI DMQ0VK9 DMQ0VK9 DN Sulfamic acid ester derivative 1 DMQ0VK9 MI TTZJYKH DMQ0VK9 MN Indoleamine 2,3-dioxygenase 1 (IDO1) DMQ0VK9 MT DTT DMQ0VK9 MA Inhibitor DMQ0VK9 RN A patent review of IDO1 inhibitors for cancer.Expert Opin Ther Pat. 2018 Apr;28(4):317-330. DMQ0VK9 RU https://www.ncbi.nlm.nih.gov/pubmed/29473428 DMO7ZRW DI DMO7ZRW DMO7ZRW DN Sulfamoylamide derivative 1 DMO7ZRW MI TTZJYKH DMO7ZRW MN Indoleamine 2,3-dioxygenase 1 (IDO1) DMO7ZRW MT DTT DMO7ZRW MA Inhibitor DMO7ZRW RN A patent review of IDO1 inhibitors for cancer.Expert Opin Ther Pat. 2018 Apr;28(4):317-330. DMO7ZRW RU https://www.ncbi.nlm.nih.gov/pubmed/29473428 DMTX21L DI DMTX21L DMTX21L DN Sulfonamide derivative 1 DMTX21L MI TT6OEDT DMTX21L MN Cannabinoid receptor 1 (CB1) DMTX21L MT DTT DMTX21L MA Antagonist DMTX21L RN A comprehensive patents review on cannabinoid 1 receptor antagonists as antiobesity agents. Expert Opin Ther Pat. 2015 Oct;25(10):1093-116. DMTX21L RU https://pubmed.ncbi.nlm.nih.gov/26161824 DMA32GJ DI DMA32GJ DMA32GJ DN Sulfonamide derivative 10 DMA32GJ MI TTA592U DMA32GJ MN Urate anion exchanger 1 (URAT1) DMA32GJ MT DTT DMA32GJ MA Inhibitor DMA32GJ RN Urate transporter URAT1 inhibitors: a patent review (2012 - 2015).Expert Opin Ther Pat. 2016 Jul 30:1-10. DMA32GJ RU https://www.ncbi.nlm.nih.gov/pubmed/27414413 DMJBR86 DI DMJBR86 DMJBR86 DN Sulfonamide derivative 11 DMJBR86 MI TTA592U DMJBR86 MN Urate anion exchanger 1 (URAT1) DMJBR86 MT DTT DMJBR86 MA Inhibitor DMJBR86 RN Urate transporter URAT1 inhibitors: a patent review (2012 - 2015).Expert Opin Ther Pat. 2016 Jul 30:1-10. DMJBR86 RU https://www.ncbi.nlm.nih.gov/pubmed/27414413 DMXEL56 DI DMXEL56 DMXEL56 DN Sulfonamide derivative 12 DMXEL56 MI TT2LVK8 DMXEL56 MN Carbonic anhydrase IX (CA-IX) DMXEL56 MT DTT DMXEL56 MA Inhibitor DMXEL56 RN Carbonic anhydrase inhibitors as antitumor/antimetastatic agents: a patent review (2008-2018).Expert Opin Ther Pat. 2018 Oct;28(10):729-740. DMXEL56 RU https://www.ncbi.nlm.nih.gov/pubmed/30074415 DM5CUSJ DI DM5CUSJ DM5CUSJ DN Sulfonamide derivative 15 DM5CUSJ MI TTZS04O DM5CUSJ MN Gamma-secretase subunit APH-1A/1B (APH-1) DM5CUSJ MT DTT DM5CUSJ MA Inhibitor DM5CUSJ RN Cancer stem cell (CSC) inhibitors: a review of recent patents (2012-2015).Expert Opin Ther Pat. 2017 Jul;27(7):753-761. DM5CUSJ RU https://www.ncbi.nlm.nih.gov/pubmed/28460551 DMTFNGM DI DMTFNGM DMTFNGM DN Sulfonamide derivative 16 DMTFNGM MI TT5ZKDI DMTFNGM MN Histone deacetylase 6 (HDAC6) DMTFNGM MT DTT DMTFNGM MA Inhibitor DMTFNGM RN Sulfonamide inhibitors: a patent review 2013-present.Expert Opin Ther Pat. 2018 Jul;28(7):541-549. DMTFNGM RU https://www.ncbi.nlm.nih.gov/pubmed/29886770 DMIQ1PL DI DMIQ1PL DMIQ1PL DN Sulfonamide derivative 17 DMIQ1PL MI TT3M2WO DMIQ1PL MN Sphingosine kinase (SphK) DMIQ1PL MT DTT DMIQ1PL MA Inhibitor DMIQ1PL RN Sulfonamide inhibitors: a patent review 2013-present.Expert Opin Ther Pat. 2018 Jul;28(7):541-549. DMIQ1PL RU https://www.ncbi.nlm.nih.gov/pubmed/29886770 DMHTJ7N DI DMHTJ7N DMHTJ7N DN Sulfonamide derivative 18 DMHTJ7N MI TTZMAO3 DMHTJ7N MN Peroxisome proliferator-activated receptor gamma (PPAR-gamma) DMHTJ7N MT DTT DMHTJ7N MA Agonist DMHTJ7N RN PPAR ligands and their therapeutic applications: a patent review (2008 - 2014).Expert Opin Ther Pat. 2015 Feb;25(2):175-91. DMHTJ7N RU https://www.ncbi.nlm.nih.gov/pubmed/25416646 DMD51AV DI DMD51AV DMD51AV DN Sulfonamide derivative 6 DMD51AV MI TTZJYKH DMD51AV MN Indoleamine 2,3-dioxygenase 1 (IDO1) DMD51AV MT DTT DMD51AV MA Inhibitor DMD51AV RN A patent review of IDO1 inhibitors for cancer.Expert Opin Ther Pat. 2018 Apr;28(4):317-330. DMD51AV RU https://www.ncbi.nlm.nih.gov/pubmed/29473428 DMN5YUK DI DMN5YUK DMN5YUK DN Sulfonamide derivative 7 DMN5YUK MI TTZJYKH DMN5YUK MN Indoleamine 2,3-dioxygenase 1 (IDO1) DMN5YUK MT DTT DMN5YUK MA Inhibitor DMN5YUK RN A patent review of IDO1 inhibitors for cancer.Expert Opin Ther Pat. 2018 Apr;28(4):317-330. DMN5YUK RU https://www.ncbi.nlm.nih.gov/pubmed/29473428 DMOXIZC DI DMOXIZC DMOXIZC DN Sulfonamide derivative 8 DMOXIZC MI TTZJYKH DMOXIZC MN Indoleamine 2,3-dioxygenase 1 (IDO1) DMOXIZC MT DTT DMOXIZC MA Inhibitor DMOXIZC RN A patent review of IDO1 inhibitors for cancer.Expert Opin Ther Pat. 2018 Apr;28(4):317-330. DMOXIZC RU https://www.ncbi.nlm.nih.gov/pubmed/29473428 DM2RZL8 DI DM2RZL8 DM2RZL8 DN Sulfonamide derivative 9 DM2RZL8 MI TT2F4OL DM2RZL8 MN Tissue transglutaminase (TG2) DM2RZL8 MT DTT DM2RZL8 MA Inhibitor DM2RZL8 RN Transglutaminase inhibitors: a patent review.Expert Opin Ther Pat. 2016;26(1):49-63. DM2RZL8 RU https://www.ncbi.nlm.nih.gov/pubmed/26560530 DMP9Z34 DI DMP9Z34 DMP9Z34 DN Sulfonamide-thiadiazole derivative 1 DMP9Z34 MI TT2LVK8 DMP9Z34 MN Carbonic anhydrase IX (CA-IX) DMP9Z34 MT DTT DMP9Z34 MA Inhibitor DMP9Z34 RN Carbonic anhydrase inhibitors as antitumor/antimetastatic agents: a patent review (2008-2018).Expert Opin Ther Pat. 2018 Oct;28(10):729-740. DMP9Z34 RU https://www.ncbi.nlm.nih.gov/pubmed/30074415 DMZAE78 DI DMZAE78 DMZAE78 DN Sulfonamide-thiadiazole derivative 2 DMZAE78 MI TT2LVK8 DMZAE78 MN Carbonic anhydrase IX (CA-IX) DMZAE78 MT DTT DMZAE78 MA Inhibitor DMZAE78 RN Carbonic anhydrase inhibitors as antitumor/antimetastatic agents: a patent review (2008-2018).Expert Opin Ther Pat. 2018 Oct;28(10):729-740. DMZAE78 RU https://www.ncbi.nlm.nih.gov/pubmed/30074415 DMCO8JD DI DMCO8JD DMCO8JD DN Sulfonylated piperazine derivative 1 DMCO8JD MI TT6OEDT DMCO8JD MN Cannabinoid receptor 1 (CB1) DMCO8JD MT DTT DMCO8JD MA Antagonist DMCO8JD RN A comprehensive patents review on cannabinoid 1 receptor antagonists as antiobesity agents. Expert Opin Ther Pat. 2015 Oct;25(10):1093-116. DMCO8JD RU https://pubmed.ncbi.nlm.nih.gov/26161824 DMZYPV3 DI DMZYPV3 DMZYPV3 DN Sulfonylated piperazine derivative 2 DMZYPV3 MI TT6OEDT DMZYPV3 MN Cannabinoid receptor 1 (CB1) DMZYPV3 MT DTT DMZYPV3 MA Antagonist DMZYPV3 RN A comprehensive patents review on cannabinoid 1 receptor antagonists as antiobesity agents. Expert Opin Ther Pat. 2015 Oct;25(10):1093-116. DMZYPV3 RU https://pubmed.ncbi.nlm.nih.gov/26161824 DMOJAZ9 DI DMOJAZ9 DMOJAZ9 DN Sulfonylated piperazine derivative 3 DMOJAZ9 MI TT6OEDT DMOJAZ9 MN Cannabinoid receptor 1 (CB1) DMOJAZ9 MT DTT DMOJAZ9 MA Antagonist DMOJAZ9 RN A comprehensive patents review on cannabinoid 1 receptor antagonists as antiobesity agents. Expert Opin Ther Pat. 2015 Oct;25(10):1093-116. DMOJAZ9 RU https://pubmed.ncbi.nlm.nih.gov/26161824 DMZW2XP DI DMZW2XP DMZW2XP DN Sulfonylated piperazine derivative 4 DMZW2XP MI TT6OEDT DMZW2XP MN Cannabinoid receptor 1 (CB1) DMZW2XP MT DTT DMZW2XP MA Antagonist DMZW2XP RN A comprehensive patents review on cannabinoid 1 receptor antagonists as antiobesity agents. Expert Opin Ther Pat. 2015 Oct;25(10):1093-116. DMZW2XP RU https://pubmed.ncbi.nlm.nih.gov/26161824 DM65NBS DI DM65NBS DM65NBS DN Sulfonylated piperazine derivative 5 DM65NBS MI TT6OEDT DM65NBS MN Cannabinoid receptor 1 (CB1) DM65NBS MT DTT DM65NBS MA Antagonist DM65NBS RN A comprehensive patents review on cannabinoid 1 receptor antagonists as antiobesity agents. Expert Opin Ther Pat. 2015 Oct;25(10):1093-116. DM65NBS RU https://pubmed.ncbi.nlm.nih.gov/26161824 DMHO29Y DI DMHO29Y DMHO29Y DN T83193 DMHO29Y MI TTT2LD9 DMHO29Y MN GABA transaminase (ABAT) DMHO29Y MT DTT DMHO29Y MA Inhibitor DMHO29Y RN Inhibition of GABA shunt enzymes' activity by 4-hydroxybenzaldehyde derivatives. Bioorg Med Chem Lett. 2006 Feb;16(3):592-5. DMHO29Y RU https://pubmed.ncbi.nlm.nih.gov/16290145 DMHO29Y DI DMHO29Y DMHO29Y DN T83193 DMHO29Y MI TTGP7BY DMHO29Y MN Monoamine oxidase type B (MAO-B) DMHO29Y MT DTT DMHO29Y MA Inhibitor DMHO29Y RN Novel monoamine oxidase inhibitors: a patent review (2012 - 2014).Expert Opin Ther Pat. 2015 Jan;25(1):91-110. DMHO29Y RU https://www.ncbi.nlm.nih.gov/pubmed/25399762 DMHO29Y DI DMHO29Y DMHO29Y DN T83193 DMHO29Y MI TTJUWVB DMHO29Y MN Succinate-semialdehyde dehydrogenase (ALDH5A1) DMHO29Y MT DTT DMHO29Y MA Inhibitor DMHO29Y RN Inhibition of GABA shunt enzymes' activity by 4-hydroxybenzaldehyde derivatives. Bioorg Med Chem Lett. 2006 Feb;16(3):592-5. DMHO29Y RU https://pubmed.ncbi.nlm.nih.gov/16290145 DM86BDS DI DM86BDS DM86BDS DN T8361 DM86BDS MI TTOJ9QL DM86BDS MN Endoplasmic reticulum to nucleus signaling 1 (ERN1) DM86BDS MT DTT DM86BDS MA Inhibitor DM86BDS RN IRE-1 inhibitors. US8614253. DM86BDS RU http://www.freepatentsonline.com/US8614253.html DMX41ZF DI DMX41ZF DMX41ZF DN T863 DMX41ZF MI TTF8P9I DMX41ZF MN Diacylglycerol acyltransferase 1 (DGAT1) DMX41ZF MT DTT DMX41ZF MA Inhibitor DMX41ZF RN Acyltransferase inhibitors: a patent review (2010-present).Expert Opin Ther Pat. 2015 Feb;25(2):145-58. DMX41ZF RU https://www.ncbi.nlm.nih.gov/pubmed/25470667 DMFOKRW DI DMFOKRW DMFOKRW DN Tacrine heterodimer derivative 1 DMFOKRW MI TT1RS9F DMFOKRW MN Acetylcholinesterase (AChE) DMFOKRW MT DTT DMFOKRW MA Inhibitor DMFOKRW RN A patent review of butyrylcholinesterase inhibitors and reactivators 2010-2017.Expert Opin Ther Pat. 2018 Jun;28(6):455-465. DMFOKRW RU https://www.ncbi.nlm.nih.gov/pubmed/29757691 DMFOKRW DI DMFOKRW DMFOKRW DN Tacrine heterodimer derivative 1 DMFOKRW MI TTEB0GD DMFOKRW MN Cholinesterase (BCHE) DMFOKRW MT DTT DMFOKRW MA Inhibitor DMFOKRW RN A patent review of butyrylcholinesterase inhibitors and reactivators 2010-2017.Expert Opin Ther Pat. 2018 Jun;28(6):455-465. DMFOKRW RU https://www.ncbi.nlm.nih.gov/pubmed/29757691 DMJ04RQ DI DMJ04RQ DMJ04RQ DN Tacrine-caffeic acid hybrid derivative 1 DMJ04RQ MI TT1RS9F DMJ04RQ MN Acetylcholinesterase (AChE) DMJ04RQ MT DTT DMJ04RQ MA Inhibitor DMJ04RQ RN Recent advances in acetylcholinesterase Inhibitors and Reactivators: an update on the patent literature (2012-2015).Expert Opin Ther Pat. 2017 Apr;27(4):455-476. DMJ04RQ RU https://www.ncbi.nlm.nih.gov/pubmed/27967267 DMMVPSY DI DMMVPSY DMMVPSY DN Tacrine-caffeic acid hybrid derivative 2 DMMVPSY MI TT1RS9F DMMVPSY MN Acetylcholinesterase (AChE) DMMVPSY MT DTT DMMVPSY MA Inhibitor DMMVPSY RN Recent advances in acetylcholinesterase Inhibitors and Reactivators: an update on the patent literature (2012-2015).Expert Opin Ther Pat. 2017 Apr;27(4):455-476. DMMVPSY RU https://www.ncbi.nlm.nih.gov/pubmed/27967267 DM6YBTR DI DM6YBTR DM6YBTR DN Tacrine-coumarin hybrid derivative 1 DM6YBTR MI TT3WG5C DM6YBTR MN Monoamine oxidase type A (MAO-A) DM6YBTR MT DTT DM6YBTR RN MAO inhibitors and their wider applications: a patent review.Expert Opin Ther Pat. 2018 Mar;28(3):211-226. DM6YBTR RU https://www.ncbi.nlm.nih.gov/pubmed/29324067 DM6YBTR DI DM6YBTR DM6YBTR DN Tacrine-coumarin hybrid derivative 1 DM6YBTR MI TTGP7BY DM6YBTR MN Monoamine oxidase type B (MAO-B) DM6YBTR MT DTT DM6YBTR RN MAO inhibitors and their wider applications: a patent review.Expert Opin Ther Pat. 2018 Mar;28(3):211-226. DM6YBTR RU https://www.ncbi.nlm.nih.gov/pubmed/29324067 DMK0S4I DI DMK0S4I DMK0S4I DN Tacrine-dihydropyridine hybrid derivative 1 DMK0S4I MI TT1RS9F DMK0S4I MN Acetylcholinesterase (AChE) DMK0S4I MT DTT DMK0S4I RN Recent advances in acetylcholinesterase Inhibitors and Reactivators: an update on the patent literature (2012-2015).Expert Opin Ther Pat. 2017 Apr;27(4):455-476. DMK0S4I RU https://www.ncbi.nlm.nih.gov/pubmed/27967267 DMQ3K5B DI DMQ3K5B DMQ3K5B DN Tacrine-indole hybrid derivative 1 DMQ3K5B MI TT1RS9F DMQ3K5B MN Acetylcholinesterase (AChE) DMQ3K5B MT DTT DMQ3K5B MA Inhibitor DMQ3K5B RN Recent advances in acetylcholinesterase Inhibitors and Reactivators: an update on the patent literature (2012-2015).Expert Opin Ther Pat. 2017 Apr;27(4):455-476. DMQ3K5B RU https://www.ncbi.nlm.nih.gov/pubmed/27967267 DMH9N2T DI DMH9N2T DMH9N2T DN Tacrine-indole hybrid derivative 2 DMH9N2T MI TT1RS9F DMH9N2T MN Acetylcholinesterase (AChE) DMH9N2T MT DTT DMH9N2T MA Inhibitor DMH9N2T RN Recent advances in acetylcholinesterase Inhibitors and Reactivators: an update on the patent literature (2012-2015).Expert Opin Ther Pat. 2017 Apr;27(4):455-476. DMH9N2T RU https://www.ncbi.nlm.nih.gov/pubmed/27967267 DMUTKNW DI DMUTKNW DMUTKNW DN Tacrine-indole hybrid derivative 3 DMUTKNW MI TT1RS9F DMUTKNW MN Acetylcholinesterase (AChE) DMUTKNW MT DTT DMUTKNW MA Inhibitor DMUTKNW RN Recent advances in acetylcholinesterase Inhibitors and Reactivators: an update on the patent literature (2012-2015).Expert Opin Ther Pat. 2017 Apr;27(4):455-476. DMUTKNW RU https://www.ncbi.nlm.nih.gov/pubmed/27967267 DMNGY8R DI DMNGY8R DMNGY8R DN Tacrine-phenothiazine hybrid derivative 1 DMNGY8R MI TT1RS9F DMNGY8R MN Acetylcholinesterase (AChE) DMNGY8R MT DTT DMNGY8R MA Inhibitor DMNGY8R RN Recent advances in acetylcholinesterase Inhibitors and Reactivators: an update on the patent literature (2012-2015).Expert Opin Ther Pat. 2017 Apr;27(4):455-476. DMNGY8R RU https://www.ncbi.nlm.nih.gov/pubmed/27967267 DMK5HAC DI DMK5HAC DMK5HAC DN Tarizine derivative 1 DMK5HAC MI TT4G2JS DMK5HAC MN Voltage-gated sodium channel alpha Nav1.7 (SCN9A) DMK5HAC MT DTT DMK5HAC MA Inhibitor DMK5HAC RN Sodium channel blockers: a patent review (2010 - 2014).Expert Opin Ther Pat. 2015 Mar;25(3):279-90. DMK5HAC RU https://www.ncbi.nlm.nih.gov/pubmed/25539043 DMQKOMR DI DMQKOMR DMQKOMR DN Tarnylcypromine derivative 1 DMQKOMR MI TTNR0UQ DMQKOMR MN Lysine-specific histone demethylase 1 (LSD) DMQKOMR MT DTT DMQKOMR MA Inhibitor DMQKOMR RN LSD1 inhibitors: a patent review (2010-2015).Expert Opin Ther Pat. 2016 May;26(5):565-80. DMQKOMR RU https://www.ncbi.nlm.nih.gov/pubmed/27019002 DMEJR2F DI DMEJR2F DMEJR2F DN Tarnylcypromine derivative 2 DMEJR2F MI TTNR0UQ DMEJR2F MN Lysine-specific histone demethylase 1 (LSD) DMEJR2F MT DTT DMEJR2F MA Inhibitor DMEJR2F RN LSD1 inhibitors: a patent review (2010-2015).Expert Opin Ther Pat. 2016 May;26(5):565-80. DMEJR2F RU https://www.ncbi.nlm.nih.gov/pubmed/27019002 DMEJR2F DI DMEJR2F DMEJR2F DN Tarnylcypromine derivative 2 DMEJR2F MI TT8VP2T DMEJR2F MN Lysine-specific histone demethylase 1B (KDM1B) DMEJR2F MT DTT DMEJR2F MA Inhibitor DMEJR2F RN LSD1 inhibitors: a patent review (2010-2015).Expert Opin Ther Pat. 2016 May;26(5):565-80. DMEJR2F RU https://www.ncbi.nlm.nih.gov/pubmed/27019002 DMEJR2F DI DMEJR2F DMEJR2F DN Tarnylcypromine derivative 2 DMEJR2F MI TT3WG5C DMEJR2F MN Monoamine oxidase type A (MAO-A) DMEJR2F MT DTT DMEJR2F MA Inhibitor DMEJR2F RN LSD1 inhibitors: a patent review (2010-2015).Expert Opin Ther Pat. 2016 May;26(5):565-80. DMEJR2F RU https://www.ncbi.nlm.nih.gov/pubmed/27019002 DMEJR2F DI DMEJR2F DMEJR2F DN Tarnylcypromine derivative 2 DMEJR2F MI TTGP7BY DMEJR2F MN Monoamine oxidase type B (MAO-B) DMEJR2F MT DTT DMEJR2F MA Inhibitor DMEJR2F RN LSD1 inhibitors: a patent review (2010-2015).Expert Opin Ther Pat. 2016 May;26(5):565-80. DMEJR2F RU https://www.ncbi.nlm.nih.gov/pubmed/27019002 DMKJOMC DI DMKJOMC DMKJOMC DN Tarnylcypromine derivative 3 DMKJOMC MI TTNR0UQ DMKJOMC MN Lysine-specific histone demethylase 1 (LSD) DMKJOMC MT DTT DMKJOMC MA Inhibitor DMKJOMC RN LSD1 inhibitors: a patent review (2010-2015).Expert Opin Ther Pat. 2016 May;26(5):565-80. DMKJOMC RU https://www.ncbi.nlm.nih.gov/pubmed/27019002 DMKJOMC DI DMKJOMC DMKJOMC DN Tarnylcypromine derivative 3 DMKJOMC MI TT8VP2T DMKJOMC MN Lysine-specific histone demethylase 1B (KDM1B) DMKJOMC MT DTT DMKJOMC MA Inhibitor DMKJOMC RN LSD1 inhibitors: a patent review (2010-2015).Expert Opin Ther Pat. 2016 May;26(5):565-80. DMKJOMC RU https://www.ncbi.nlm.nih.gov/pubmed/27019002 DMKJOMC DI DMKJOMC DMKJOMC DN Tarnylcypromine derivative 3 DMKJOMC MI TT3WG5C DMKJOMC MN Monoamine oxidase type A (MAO-A) DMKJOMC MT DTT DMKJOMC MA Inhibitor DMKJOMC RN LSD1 inhibitors: a patent review (2010-2015).Expert Opin Ther Pat. 2016 May;26(5):565-80. DMKJOMC RU https://www.ncbi.nlm.nih.gov/pubmed/27019002 DMKJOMC DI DMKJOMC DMKJOMC DN Tarnylcypromine derivative 3 DMKJOMC MI TTGP7BY DMKJOMC MN Monoamine oxidase type B (MAO-B) DMKJOMC MT DTT DMKJOMC MA Inhibitor DMKJOMC RN LSD1 inhibitors: a patent review (2010-2015).Expert Opin Ther Pat. 2016 May;26(5):565-80. DMKJOMC RU https://www.ncbi.nlm.nih.gov/pubmed/27019002 DMG6Q45 DI DMG6Q45 DMG6Q45 DN TDZD-8 DMG6Q45 MI TTRZQE3 DMG6Q45 MN Glycogen synthase kinase-3 alpha (GSK-3A) DMG6Q45 MT DTT DMG6Q45 MA Inhibitor DMG6Q45 RN Glycogen synthase kinase 3 (GSK-3) inhibitors: a patent update (2014-2015).Expert Opin Ther Pat. 2017 Jun;27(6):657-666. DMG6Q45 RU https://www.ncbi.nlm.nih.gov/pubmed/27828716 DMG6Q45 DI DMG6Q45 DMG6Q45 DN TDZD-8 DMG6Q45 MI TTRSMW9 DMG6Q45 MN Glycogen synthase kinase-3 beta (GSK-3B) DMG6Q45 MT DTT DMG6Q45 MA Inhibitor DMG6Q45 RN Identification of novel scaffold of benzothiazepinones as non-ATP competitive glycogen synthase kinase-3beta inhibitors through virtual screening. Bioorg Med Chem Lett. 2012 Dec 1;22(23):7232-6. DMG6Q45 RU https://pubmed.ncbi.nlm.nih.gov/23099099 DMFMZCW DI DMFMZCW DMFMZCW DN Terpyridineplatinum(II) complexe 1 DMFMZCW MI TTR7UJ3 DMFMZCW MN Cytoplasmic thioredoxin reductase (TXNRD1) DMFMZCW MT DTT DMFMZCW MA Inhibitor DMFMZCW RN Thioredoxin reductase inhibitors: a patent review.Expert Opin Ther Pat. 2017 May;27(5):547-556. DMFMZCW RU https://www.ncbi.nlm.nih.gov/pubmed/27977313 DMLUYR0 DI DMLUYR0 DMLUYR0 DN Terpyridineplatinum(II) complexe 2 DMLUYR0 MI TTR7UJ3 DMLUYR0 MN Cytoplasmic thioredoxin reductase (TXNRD1) DMLUYR0 MT DTT DMLUYR0 MA Inhibitor DMLUYR0 RN Thioredoxin reductase inhibitors: a patent review.Expert Opin Ther Pat. 2017 May;27(5):547-556. DMLUYR0 RU https://www.ncbi.nlm.nih.gov/pubmed/27977313 DM54EFD DI DM54EFD DM54EFD DN Terpyridineplatinum(II) complexe 3 DM54EFD MI TTR7UJ3 DM54EFD MN Cytoplasmic thioredoxin reductase (TXNRD1) DM54EFD MT DTT DM54EFD MA Inhibitor DM54EFD RN Thioredoxin reductase inhibitors: a patent review.Expert Opin Ther Pat. 2017 May;27(5):547-556. DM54EFD RU https://www.ncbi.nlm.nih.gov/pubmed/27977313 DM54EFD DI DM54EFD DM54EFD DN Terpyridineplatinum(II) complexe 3 DM54EFD MI TTEP6RV DM54EFD MN Glutathione reductase (GR) DM54EFD MT DTT DM54EFD MA Inhibitor DM54EFD RN Thioredoxin reductase inhibitors: a patent review.Expert Opin Ther Pat. 2017 May;27(5):547-556. DM54EFD RU https://www.ncbi.nlm.nih.gov/pubmed/27977313 DMOV86T DI DMOV86T DMOV86T DN Terpyridineplatinum(II) complexe 4 DMOV86T MI TTR7UJ3 DMOV86T MN Cytoplasmic thioredoxin reductase (TXNRD1) DMOV86T MT DTT DMOV86T MA Inhibitor DMOV86T RN Thioredoxin reductase inhibitors: a patent review.Expert Opin Ther Pat. 2017 May;27(5):547-556. DMOV86T RU https://www.ncbi.nlm.nih.gov/pubmed/27977313 DMOV86T DI DMOV86T DMOV86T DN Terpyridineplatinum(II) complexe 4 DMOV86T MI TTEP6RV DMOV86T MN Glutathione reductase (GR) DMOV86T MT DTT DMOV86T MA Inhibitor DMOV86T RN Thioredoxin reductase inhibitors: a patent review.Expert Opin Ther Pat. 2017 May;27(5):547-556. DMOV86T RU https://www.ncbi.nlm.nih.gov/pubmed/27977313 DMI4MJ2 DI DMI4MJ2 DMI4MJ2 DN Terpyridineplatinum(II) complexe 5 DMI4MJ2 MI TTR7UJ3 DMI4MJ2 MN Cytoplasmic thioredoxin reductase (TXNRD1) DMI4MJ2 MT DTT DMI4MJ2 MA Inhibitor DMI4MJ2 RN Thioredoxin reductase inhibitors: a patent review.Expert Opin Ther Pat. 2017 May;27(5):547-556. DMI4MJ2 RU https://www.ncbi.nlm.nih.gov/pubmed/27977313 DMS3YPJ DI DMS3YPJ DMS3YPJ DN Tetra/penta-cyclic pyridophthalazinone derivative 1 DMS3YPJ MI TTEBCY8 DMS3YPJ MN Poly [ADP-ribose] polymerase (PARP) DMS3YPJ MT DTT DMS3YPJ MA Inhibitor DMS3YPJ RN PARP inhibitors as antitumor agents: a patent update (2013-2015).Expert Opin Ther Pat. 2017 Mar;27(3):363-382. DMS3YPJ RU https://www.ncbi.nlm.nih.gov/pubmed/27841036 DMLRY53 DI DMLRY53 DMLRY53 DN Tetra-azabenzo[e]azulene derivative 1 DMLRY53 MI TT4TFGN DMLRY53 MN Vasopressin V1a receptor (V1AR) DMLRY53 MT DTT DMLRY53 MA Inhibitor DMLRY53 RN Vasopressin V1a and V1b receptor modulators: a patent review (2012 - 2014).Expert Opin Ther Pat. 2015 Jun;25(6):711-22. DMLRY53 RU https://www.ncbi.nlm.nih.gov/pubmed/25776143 DMUEI4N DI DMUEI4N DMUEI4N DN Tetra-azabenzo[e]azulene derivative 2 DMUEI4N MI TT4TFGN DMUEI4N MN Vasopressin V1a receptor (V1AR) DMUEI4N MT DTT DMUEI4N MA Inhibitor DMUEI4N RN Vasopressin V1a and V1b receptor modulators: a patent review (2012 - 2014).Expert Opin Ther Pat. 2015 Jun;25(6):711-22. DMUEI4N RU https://www.ncbi.nlm.nih.gov/pubmed/25776143 DMS1GJD DI DMS1GJD DMS1GJD DN Tetra-cyclic compound 1 DMS1GJD MI TTJSQEF DMS1GJD MN Tyrosine-protein kinase (PTK) DMS1GJD MT DTT DMS1GJD MA Inhibitor DMS1GJD RN Inhibitors of JAK-family kinases: an update on the patent literature 2013-2015, part 1.Expert Opin Ther Pat. 2017 Feb;27(2):127-143. DMS1GJD RU https://www.ncbi.nlm.nih.gov/pubmed/27774824 DMX2EFL DI DMX2EFL DMX2EFL DN Tetra-cyclic pyridophthalazinone derivative 1 DMX2EFL MI TTVDSZ0 DMX2EFL MN Poly [ADP-ribose] polymerase 1 (PARP1) DMX2EFL MT DTT DMX2EFL MA Inhibitor DMX2EFL RN PARP inhibitors as antitumor agents: a patent update (2013-2015).Expert Opin Ther Pat. 2017 Mar;27(3):363-382. DMX2EFL RU https://www.ncbi.nlm.nih.gov/pubmed/27841036 DMX2EFL DI DMX2EFL DMX2EFL DN Tetra-cyclic pyridophthalazinone derivative 1 DMX2EFL MI TTQ4V96 DMX2EFL MN Poly [ADP-ribose] polymerase 2 (PARP2) DMX2EFL MT DTT DMX2EFL MA Inhibitor DMX2EFL RN PARP inhibitors as antitumor agents: a patent update (2013-2015).Expert Opin Ther Pat. 2017 Mar;27(3):363-382. DMX2EFL RU https://www.ncbi.nlm.nih.gov/pubmed/27841036 DMUXNKG DI DMUXNKG DMUXNKG DN Tetra-hydro-1H-1,2,6-triazaazulene derivative 1 DMUXNKG MI TT6OEDT DMUXNKG MN Cannabinoid receptor 1 (CB1) DMUXNKG MT DTT DMUXNKG MA Antagonist DMUXNKG RN A comprehensive patents review on cannabinoid 1 receptor antagonists as antiobesity agents. Expert Opin Ther Pat. 2015 Oct;25(10):1093-116. DMUXNKG RU https://pubmed.ncbi.nlm.nih.gov/26161824 DMVTZ6S DI DMVTZ6S DMVTZ6S DN Tetra-hydro-1H-1,2,6-triazaazulene derivative 2 DMVTZ6S MI TT6OEDT DMVTZ6S MN Cannabinoid receptor 1 (CB1) DMVTZ6S MT DTT DMVTZ6S MA Antagonist DMVTZ6S RN A comprehensive patents review on cannabinoid 1 receptor antagonists as antiobesity agents. Expert Opin Ther Pat. 2015 Oct;25(10):1093-116. DMVTZ6S RU https://pubmed.ncbi.nlm.nih.gov/26161824 DM5MVLG DI DM5MVLG DM5MVLG DN Tetra-hydro-carboline derivative 1 DM5MVLG MI TTSCIM2 DM5MVLG MN Extracellular lysophospholipase D (E-NPP2) DM5MVLG MT DTT DM5MVLG MA Inhibitor DM5MVLG RN Autotaxin inhibitors: a patent review (2012-2016).Expert Opin Ther Pat. 2017 Jul;27(7):815-829. DM5MVLG RU https://www.ncbi.nlm.nih.gov/pubmed/28447479 DMXTL7V DI DMXTL7V DMXTL7V DN Tetra-hydro-carboline derivative 2 DMXTL7V MI TTSCIM2 DMXTL7V MN Extracellular lysophospholipase D (E-NPP2) DMXTL7V MT DTT DMXTL7V MA Inhibitor DMXTL7V RN Autotaxin inhibitors: a patent review (2012-2016).Expert Opin Ther Pat. 2017 Jul;27(7):815-829. DMXTL7V RU https://www.ncbi.nlm.nih.gov/pubmed/28447479 DM3W5SM DI DM3W5SM DM3W5SM DN Tetra-hydro-imidazo[1,5-d][1,4]oxazepin-3-yl derivative 1 DM3W5SM MI TTXJ47W DM3W5SM MN Metabotropic glutamate receptor 2 (mGluR2) DM3W5SM MT DTT DM3W5SM MA Antagonist DM3W5SM RN Novel metabotropic glutamate receptor 2/3 antagonists and their therapeutic applications: a patent review (2005 - present).Expert Opin Ther Pat. 2015 Jan;25(1):69-90. DM3W5SM RU https://www.ncbi.nlm.nih.gov/pubmed/25435285 DMB1T6S DI DMB1T6S DMB1T6S DN Tetra-hydro-imidazo[1,5-d][1,4]oxazepin-3-yl derivative 2 DMB1T6S MI TTXJ47W DMB1T6S MN Metabotropic glutamate receptor 2 (mGluR2) DMB1T6S MT DTT DMB1T6S MA Antagonist DMB1T6S RN Novel metabotropic glutamate receptor 2/3 antagonists and their therapeutic applications: a patent review (2005 - present).Expert Opin Ther Pat. 2015 Jan;25(1):69-90. DMB1T6S RU https://www.ncbi.nlm.nih.gov/pubmed/25435285 DM71LVY DI DM71LVY DM71LVY DN Tetra-hydro-imidazo[1,5-d][1,4]oxazepin-3-yl derivative 3 DM71LVY MI TTXJ47W DM71LVY MN Metabotropic glutamate receptor 2 (mGluR2) DM71LVY MT DTT DM71LVY MA Antagonist DM71LVY RN Novel metabotropic glutamate receptor 2/3 antagonists and their therapeutic applications: a patent review (2005 - present).Expert Opin Ther Pat. 2015 Jan;25(1):69-90. DM71LVY RU https://www.ncbi.nlm.nih.gov/pubmed/25435285 DMLMXT6 DI DMLMXT6 DMLMXT6 DN Tetra-hydro-imidazo[1,5-d][1,4]oxazepin-3-yl derivative 4 DMLMXT6 MI TTXJ47W DMLMXT6 MN Metabotropic glutamate receptor 2 (mGluR2) DMLMXT6 MT DTT DMLMXT6 MA Antagonist DMLMXT6 RN Novel metabotropic glutamate receptor 2/3 antagonists and their therapeutic applications: a patent review (2005 - present).Expert Opin Ther Pat. 2015 Jan;25(1):69-90. DMLMXT6 RU https://www.ncbi.nlm.nih.gov/pubmed/25435285 DM7C0R8 DI DM7C0R8 DM7C0R8 DN Tetra-hydro-imidazo[1,5-d][1,4]oxazepin-3-yl derivative 5 DM7C0R8 MI TTXJ47W DM7C0R8 MN Metabotropic glutamate receptor 2 (mGluR2) DM7C0R8 MT DTT DM7C0R8 MA Antagonist DM7C0R8 RN Novel metabotropic glutamate receptor 2/3 antagonists and their therapeutic applications: a patent review (2005 - present).Expert Opin Ther Pat. 2015 Jan;25(1):69-90. DM7C0R8 RU https://www.ncbi.nlm.nih.gov/pubmed/25435285 DMCE3J0 DI DMCE3J0 DMCE3J0 DN Tetra-hydro-imidazo[1,5-d][1,4]oxazepin-3-yl derivative 6 DMCE3J0 MI TTXJ47W DMCE3J0 MN Metabotropic glutamate receptor 2 (mGluR2) DMCE3J0 MT DTT DMCE3J0 MA Antagonist DMCE3J0 RN Novel metabotropic glutamate receptor 2/3 antagonists and their therapeutic applications: a patent review (2005 - present).Expert Opin Ther Pat. 2015 Jan;25(1):69-90. DMCE3J0 RU https://www.ncbi.nlm.nih.gov/pubmed/25435285 DML86IO DI DML86IO DML86IO DN Tetra-hydro-isoquinoline derivative 1 DML86IO MI TT1RS9F DML86IO MN Acetylcholinesterase (AChE) DML86IO MT DTT DML86IO MA Inhibitor DML86IO RN A patent review of butyrylcholinesterase inhibitors and reactivators 2010-2017.Expert Opin Ther Pat. 2018 Jun;28(6):455-465. DML86IO RU https://www.ncbi.nlm.nih.gov/pubmed/29757691 DML86IO DI DML86IO DML86IO DN Tetra-hydro-isoquinoline derivative 1 DML86IO MI TTEB0GD DML86IO MN Cholinesterase (BCHE) DML86IO MT DTT DML86IO MA Inhibitor DML86IO RN A patent review of butyrylcholinesterase inhibitors and reactivators 2010-2017.Expert Opin Ther Pat. 2018 Jun;28(6):455-465. DML86IO RU https://www.ncbi.nlm.nih.gov/pubmed/29757691 DML86IO DI DML86IO DML86IO DN Tetra-hydro-isoquinoline derivative 1 DML86IO MI TT3WG5C DML86IO MN Monoamine oxidase type A (MAO-A) DML86IO MT DTT DML86IO MA Inhibitor DML86IO RN A patent review of butyrylcholinesterase inhibitors and reactivators 2010-2017.Expert Opin Ther Pat. 2018 Jun;28(6):455-465. DML86IO RU https://www.ncbi.nlm.nih.gov/pubmed/29757691 DML86IO DI DML86IO DML86IO DN Tetra-hydro-isoquinoline derivative 1 DML86IO MI TTGP7BY DML86IO MN Monoamine oxidase type B (MAO-B) DML86IO MT DTT DML86IO MA Inhibitor DML86IO RN A patent review of butyrylcholinesterase inhibitors and reactivators 2010-2017.Expert Opin Ther Pat. 2018 Jun;28(6):455-465. DML86IO RU https://www.ncbi.nlm.nih.gov/pubmed/29757691 DM5CKVF DI DM5CKVF DM5CKVF DN Tetra-hydro-isoquinoline derivative 2 DM5CKVF MI TT1RS9F DM5CKVF MN Acetylcholinesterase (AChE) DM5CKVF MT DTT DM5CKVF MA Inhibitor DM5CKVF RN A patent review of butyrylcholinesterase inhibitors and reactivators 2010-2017.Expert Opin Ther Pat. 2018 Jun;28(6):455-465. DM5CKVF RU https://www.ncbi.nlm.nih.gov/pubmed/29757691 DM5CKVF DI DM5CKVF DM5CKVF DN Tetra-hydro-isoquinoline derivative 2 DM5CKVF MI TTEB0GD DM5CKVF MN Cholinesterase (BCHE) DM5CKVF MT DTT DM5CKVF MA Inhibitor DM5CKVF RN A patent review of butyrylcholinesterase inhibitors and reactivators 2010-2017.Expert Opin Ther Pat. 2018 Jun;28(6):455-465. DM5CKVF RU https://www.ncbi.nlm.nih.gov/pubmed/29757691 DM5CKVF DI DM5CKVF DM5CKVF DN Tetra-hydro-isoquinoline derivative 2 DM5CKVF MI TT3WG5C DM5CKVF MN Monoamine oxidase type A (MAO-A) DM5CKVF MT DTT DM5CKVF MA Inhibitor DM5CKVF RN A patent review of butyrylcholinesterase inhibitors and reactivators 2010-2017.Expert Opin Ther Pat. 2018 Jun;28(6):455-465. DM5CKVF RU https://www.ncbi.nlm.nih.gov/pubmed/29757691 DM5CKVF DI DM5CKVF DM5CKVF DN Tetra-hydro-isoquinoline derivative 2 DM5CKVF MI TTGP7BY DM5CKVF MN Monoamine oxidase type B (MAO-B) DM5CKVF MT DTT DM5CKVF MA Inhibitor DM5CKVF RN A patent review of butyrylcholinesterase inhibitors and reactivators 2010-2017.Expert Opin Ther Pat. 2018 Jun;28(6):455-465. DM5CKVF RU https://www.ncbi.nlm.nih.gov/pubmed/29757691 DMCZA45 DI DMCZA45 DMCZA45 DN Tetra-hydro-isoquinoline derivative 3 DMCZA45 MI TT1RS9F DMCZA45 MN Acetylcholinesterase (AChE) DMCZA45 MT DTT DMCZA45 MA Inhibitor DMCZA45 RN A patent review of butyrylcholinesterase inhibitors and reactivators 2010-2017.Expert Opin Ther Pat. 2018 Jun;28(6):455-465. DMCZA45 RU https://www.ncbi.nlm.nih.gov/pubmed/29757691 DMCZA45 DI DMCZA45 DMCZA45 DN Tetra-hydro-isoquinoline derivative 3 DMCZA45 MI TTEB0GD DMCZA45 MN Cholinesterase (BCHE) DMCZA45 MT DTT DMCZA45 MA Inhibitor DMCZA45 RN A patent review of butyrylcholinesterase inhibitors and reactivators 2010-2017.Expert Opin Ther Pat. 2018 Jun;28(6):455-465. DMCZA45 RU https://www.ncbi.nlm.nih.gov/pubmed/29757691 DMCZA45 DI DMCZA45 DMCZA45 DN Tetra-hydro-isoquinoline derivative 3 DMCZA45 MI TT3WG5C DMCZA45 MN Monoamine oxidase type A (MAO-A) DMCZA45 MT DTT DMCZA45 MA Inhibitor DMCZA45 RN A patent review of butyrylcholinesterase inhibitors and reactivators 2010-2017.Expert Opin Ther Pat. 2018 Jun;28(6):455-465. DMCZA45 RU https://www.ncbi.nlm.nih.gov/pubmed/29757691 DMCZA45 DI DMCZA45 DMCZA45 DN Tetra-hydro-isoquinoline derivative 3 DMCZA45 MI TTGP7BY DMCZA45 MN Monoamine oxidase type B (MAO-B) DMCZA45 MT DTT DMCZA45 MA Inhibitor DMCZA45 RN A patent review of butyrylcholinesterase inhibitors and reactivators 2010-2017.Expert Opin Ther Pat. 2018 Jun;28(6):455-465. DMCZA45 RU https://www.ncbi.nlm.nih.gov/pubmed/29757691 DMDV0MP DI DMDV0MP DMDV0MP DN Tetra-hydro-isoquinoline derivative 4 DMDV0MP MI TT1RS9F DMDV0MP MN Acetylcholinesterase (AChE) DMDV0MP MT DTT DMDV0MP MA Inhibitor DMDV0MP RN A patent review of butyrylcholinesterase inhibitors and reactivators 2010-2017.Expert Opin Ther Pat. 2018 Jun;28(6):455-465. DMDV0MP RU https://www.ncbi.nlm.nih.gov/pubmed/29757691 DMDV0MP DI DMDV0MP DMDV0MP DN Tetra-hydro-isoquinoline derivative 4 DMDV0MP MI TTEB0GD DMDV0MP MN Cholinesterase (BCHE) DMDV0MP MT DTT DMDV0MP MA Inhibitor DMDV0MP RN A patent review of butyrylcholinesterase inhibitors and reactivators 2010-2017.Expert Opin Ther Pat. 2018 Jun;28(6):455-465. DMDV0MP RU https://www.ncbi.nlm.nih.gov/pubmed/29757691 DMDV0MP DI DMDV0MP DMDV0MP DN Tetra-hydro-isoquinoline derivative 4 DMDV0MP MI TT3WG5C DMDV0MP MN Monoamine oxidase type A (MAO-A) DMDV0MP MT DTT DMDV0MP MA Inhibitor DMDV0MP RN A patent review of butyrylcholinesterase inhibitors and reactivators 2010-2017.Expert Opin Ther Pat. 2018 Jun;28(6):455-465. DMDV0MP RU https://www.ncbi.nlm.nih.gov/pubmed/29757691 DMDV0MP DI DMDV0MP DMDV0MP DN Tetra-hydro-isoquinoline derivative 4 DMDV0MP MI TTGP7BY DMDV0MP MN Monoamine oxidase type B (MAO-B) DMDV0MP MT DTT DMDV0MP MA Inhibitor DMDV0MP RN A patent review of butyrylcholinesterase inhibitors and reactivators 2010-2017.Expert Opin Ther Pat. 2018 Jun;28(6):455-465. DMDV0MP RU https://www.ncbi.nlm.nih.gov/pubmed/29757691 DMURYO0 DI DMURYO0 DMURYO0 DN Tetra-hydro-naphthalene derivative 1 DMURYO0 MI TTDP1UC DMURYO0 MN Fatty acid amide hydrolase (FAAH) DMURYO0 MT DTT DMURYO0 MA Inhibitor DMURYO0 RN Fatty acid amide hydrolase inhibitors: a patent review (2009-2014).Expert Opin Ther Pat. 2015;25(11):1247-66. DMURYO0 RU https://www.ncbi.nlm.nih.gov/pubmed/26413912 DMEBGZJ DI DMEBGZJ DMEBGZJ DN Tetra-hydro-naphthalene derivative 2 DMEBGZJ MI TTDP1UC DMEBGZJ MN Fatty acid amide hydrolase (FAAH) DMEBGZJ MT DTT DMEBGZJ MA Inhibitor DMEBGZJ RN Fatty acid amide hydrolase inhibitors: a patent review (2009-2014).Expert Opin Ther Pat. 2015;25(11):1247-66. DMEBGZJ RU https://www.ncbi.nlm.nih.gov/pubmed/26413912 DMVBZKF DI DMVBZKF DMVBZKF DN Tetra-hydro-naphthalene derivative 3 DMVBZKF MI TTDP1UC DMVBZKF MN Fatty acid amide hydrolase (FAAH) DMVBZKF MT DTT DMVBZKF MA Inhibitor DMVBZKF RN Fatty acid amide hydrolase inhibitors: a patent review (2009-2014).Expert Opin Ther Pat. 2015;25(11):1247-66. DMVBZKF RU https://www.ncbi.nlm.nih.gov/pubmed/26413912 DM5YSTU DI DM5YSTU DM5YSTU DN Tetra-hydro-naphthyridine derivative 1 DM5YSTU MI TTDP1UC DM5YSTU MN Fatty acid amide hydrolase (FAAH) DM5YSTU MT DTT DM5YSTU MA Inhibitor DM5YSTU RN Fatty acid amide hydrolase inhibitors: a patent review (2009-2014).Expert Opin Ther Pat. 2015;25(11):1247-66. DM5YSTU RU https://www.ncbi.nlm.nih.gov/pubmed/26413912 DM72MDA DI DM72MDA DM72MDA DN Tetra-hydro-oxazolopyridine derivative 1 DM72MDA MI TTHS256 DM72MDA MN Metabotropic glutamate receptor 5 (mGluR5) DM72MDA MT DTT DM72MDA MA Modulator DM72MDA RN mGlu5 negative allosteric modulators: a patent review (2013 - 2016).Expert Opin Ther Pat. 2017 Jun;27(6):691-706. DM72MDA RU https://www.ncbi.nlm.nih.gov/pubmed/28067079 DM72MDA DI DM72MDA DM72MDA DN Tetra-hydro-oxazolopyridine derivative 1 DM72MDA MI TTGP7BY DM72MDA MN Monoamine oxidase type B (MAO-B) DM72MDA MT DTT DM72MDA MA Modulator DM72MDA RN mGlu5 negative allosteric modulators: a patent review (2013 - 2016).Expert Opin Ther Pat. 2017 Jun;27(6):691-706. DM72MDA RU https://www.ncbi.nlm.nih.gov/pubmed/28067079 DMP65Z4 DI DMP65Z4 DMP65Z4 DN Tetra-hydro-oxazolopyridine derivative 2 DMP65Z4 MI TTHS256 DMP65Z4 MN Metabotropic glutamate receptor 5 (mGluR5) DMP65Z4 MT DTT DMP65Z4 MA Modulator DMP65Z4 RN mGlu5 negative allosteric modulators: a patent review (2013 - 2016).Expert Opin Ther Pat. 2017 Jun;27(6):691-706. DMP65Z4 RU https://www.ncbi.nlm.nih.gov/pubmed/28067079 DMP65Z4 DI DMP65Z4 DMP65Z4 DN Tetra-hydro-oxazolopyridine derivative 2 DMP65Z4 MI TTGP7BY DMP65Z4 MN Monoamine oxidase type B (MAO-B) DMP65Z4 MT DTT DMP65Z4 MA Modulator DMP65Z4 RN mGlu5 negative allosteric modulators: a patent review (2013 - 2016).Expert Opin Ther Pat. 2017 Jun;27(6):691-706. DMP65Z4 RU https://www.ncbi.nlm.nih.gov/pubmed/28067079 DMQYKT2 DI DMQYKT2 DMQYKT2 DN Tetra-hydro-oxazolopyridine derivative 3 DMQYKT2 MI TTHS256 DMQYKT2 MN Metabotropic glutamate receptor 5 (mGluR5) DMQYKT2 MT DTT DMQYKT2 MA Modulator DMQYKT2 RN mGlu5 negative allosteric modulators: a patent review (2013 - 2016).Expert Opin Ther Pat. 2017 Jun;27(6):691-706. DMQYKT2 RU https://www.ncbi.nlm.nih.gov/pubmed/28067079 DM21J83 DI DM21J83 DM21J83 DN Tetra-hydro-oxazolopyridine derivative 4 DM21J83 MI TTHS256 DM21J83 MN Metabotropic glutamate receptor 5 (mGluR5) DM21J83 MT DTT DM21J83 MA Modulator DM21J83 RN mGlu5 negative allosteric modulators: a patent review (2013 - 2016).Expert Opin Ther Pat. 2017 Jun;27(6):691-706. DM21J83 RU https://www.ncbi.nlm.nih.gov/pubmed/28067079 DMQGA1I DI DMQGA1I DMQGA1I DN Tetra-hydro-oxazolopyridine derivative 5 DMQGA1I MI TTHS256 DMQGA1I MN Metabotropic glutamate receptor 5 (mGluR5) DMQGA1I MT DTT DMQGA1I MA Modulator DMQGA1I RN mGlu5 negative allosteric modulators: a patent review (2013 - 2016).Expert Opin Ther Pat. 2017 Jun;27(6):691-706. DMQGA1I RU https://www.ncbi.nlm.nih.gov/pubmed/28067079 DMLW7YO DI DMLW7YO DMLW7YO DN Tetra-hydro-oxazolopyridine derivative 6 DMLW7YO MI TTHS256 DMLW7YO MN Metabotropic glutamate receptor 5 (mGluR5) DMLW7YO MT DTT DMLW7YO MA Modulator DMLW7YO RN mGlu5 negative allosteric modulators: a patent review (2013 - 2016).Expert Opin Ther Pat. 2017 Jun;27(6):691-706. DMLW7YO RU https://www.ncbi.nlm.nih.gov/pubmed/28067079 DM3HVCZ DI DM3HVCZ DM3HVCZ DN Tetra-hydro-pyrazolopyrazine derivative 1 DM3HVCZ MI TTHS256 DM3HVCZ MN Metabotropic glutamate receptor 5 (mGluR5) DM3HVCZ MT DTT DM3HVCZ MA Modulator DM3HVCZ RN mGlu5 negative allosteric modulators: a patent review (2013 - 2016).Expert Opin Ther Pat. 2017 Jun;27(6):691-706. DM3HVCZ RU https://www.ncbi.nlm.nih.gov/pubmed/28067079 DMQ027F DI DMQ027F DMQ027F DN Tetra-hydro-pyrazolopyrazine derivative 2 DMQ027F MI TTHS256 DMQ027F MN Metabotropic glutamate receptor 5 (mGluR5) DMQ027F MT DTT DMQ027F MA Modulator DMQ027F RN mGlu5 negative allosteric modulators: a patent review (2013 - 2016).Expert Opin Ther Pat. 2017 Jun;27(6):691-706. DMQ027F RU https://www.ncbi.nlm.nih.gov/pubmed/28067079 DMKGJ1S DI DMKGJ1S DMKGJ1S DN Tetra-hydro-pyrazolopyrazine derivative 3 DMKGJ1S MI TTHS256 DMKGJ1S MN Metabotropic glutamate receptor 5 (mGluR5) DMKGJ1S MT DTT DMKGJ1S MA Modulator DMKGJ1S RN mGlu5 negative allosteric modulators: a patent review (2013 - 2016).Expert Opin Ther Pat. 2017 Jun;27(6):691-706. DMKGJ1S RU https://www.ncbi.nlm.nih.gov/pubmed/28067079 DMRMTF6 DI DMRMTF6 DMRMTF6 DN Tetra-hydro-pyrazolopyrazine derivative 4 DMRMTF6 MI TTHS256 DMRMTF6 MN Metabotropic glutamate receptor 5 (mGluR5) DMRMTF6 MT DTT DMRMTF6 MA Modulator DMRMTF6 RN mGlu5 negative allosteric modulators: a patent review (2013 - 2016).Expert Opin Ther Pat. 2017 Jun;27(6):691-706. DMRMTF6 RU https://www.ncbi.nlm.nih.gov/pubmed/28067079 DMAM7Y2 DI DMAM7Y2 DMAM7Y2 DN Tetra-hydro-pyrazolopyrazine derivative 5 DMAM7Y2 MI TTHS256 DMAM7Y2 MN Metabotropic glutamate receptor 5 (mGluR5) DMAM7Y2 MT DTT DMAM7Y2 MA Modulator DMAM7Y2 RN mGlu5 negative allosteric modulators: a patent review (2013 - 2016).Expert Opin Ther Pat. 2017 Jun;27(6):691-706. DMAM7Y2 RU https://www.ncbi.nlm.nih.gov/pubmed/28067079 DMM06K5 DI DMM06K5 DMM06K5 DN Tetra-hydro-pyrrolopyrimidinedione derivative 1 DMM06K5 MI TTPLTSQ DMM06K5 MN Neutrophil elastase (NE) DMM06K5 MT DTT DMM06K5 MA Inhibitor DMM06K5 RN Neutrophil elastase inhibitors: a patent review and potential applications for inflammatory lung diseases (2010 - 2014).Expert Opin Ther Pat. 2015;25(10):1145-58. DMM06K5 RU https://www.ncbi.nlm.nih.gov/pubmed/26118988 DMM92KW DI DMM92KW DMM92KW DN Tetra-hydro-quinoline derivative 1 DMM92KW MI TTVDSZ0 DMM92KW MN Poly [ADP-ribose] polymerase 1 (PARP1) DMM92KW MT DTT DMM92KW MA Inhibitor DMM92KW RN PARP inhibitors as antitumor agents: a patent update (2013-2015).Expert Opin Ther Pat. 2017 Mar;27(3):363-382. DMM92KW RU https://www.ncbi.nlm.nih.gov/pubmed/27841036 DMEKO71 DI DMEKO71 DMEKO71 DN Tetra-hydro-quinoline derivative 2 DMEKO71 MI TTE4BSY DMEKO71 MN Bromodomain and extraterminal domain protein (BET) DMEKO71 MT DTT DMEKO71 MA Inhibitor DMEKO71 RN BET inhibitors in cancer therapeutics: a patent review.Expert Opin Ther Pat. 2016;26(4):505-22. DMEKO71 RU https://www.ncbi.nlm.nih.gov/pubmed/26924192 DMAWY4L DI DMAWY4L DMAWY4L DN Tetra-hydro-quinoline derivative 3 DMAWY4L MI TTE4BSY DMAWY4L MN Bromodomain and extraterminal domain protein (BET) DMAWY4L MT DTT DMAWY4L MA Inhibitor DMAWY4L RN BET inhibitors in cancer therapeutics: a patent review.Expert Opin Ther Pat. 2016;26(4):505-22. DMAWY4L RU https://www.ncbi.nlm.nih.gov/pubmed/26924192 DMMC3AG DI DMMC3AG DMMC3AG DN Tetra-hydro-quinoline derivative 4 DMMC3AG MI TTE4BSY DMMC3AG MN Bromodomain and extraterminal domain protein (BET) DMMC3AG MT DTT DMMC3AG MA Inhibitor DMMC3AG RN BET inhibitors in cancer therapeutics: a patent review.Expert Opin Ther Pat. 2016;26(4):505-22. DMMC3AG RU https://www.ncbi.nlm.nih.gov/pubmed/26924192 DMI6VG9 DI DMI6VG9 DMI6VG9 DN Tetra-hydro-triazolopyrimidine derivative 2 DMI6VG9 MI TTPLTSQ DMI6VG9 MN Neutrophil elastase (NE) DMI6VG9 MT DTT DMI6VG9 MA Inhibitor DMI6VG9 RN Serine protease inhibitors to treat inflammation: a patent review (2011-2016).Expert Opin Ther Pat. 2018 Feb;28(2):93-110. DMI6VG9 RU https://www.ncbi.nlm.nih.gov/pubmed/29171765 DMEG5YO DI DMEG5YO DMEG5YO DN Tetra-substituted urea derivative 1 DMEG5YO MI TTDP1UC DMEG5YO MN Fatty acid amide hydrolase (FAAH) DMEG5YO MT DTT DMEG5YO MA Inhibitor DMEG5YO RN Fatty acid amide hydrolase inhibitors: a patent review (2009-2014).Expert Opin Ther Pat. 2015;25(11):1247-66. DMEG5YO RU https://www.ncbi.nlm.nih.gov/pubmed/26413912 DMKXZUA DI DMKXZUA DMKXZUA DN Tetra-substituted urea derivative 2 DMKXZUA MI TTDP1UC DMKXZUA MN Fatty acid amide hydrolase (FAAH) DMKXZUA MT DTT DMKXZUA MA Inhibitor DMKXZUA RN Fatty acid amide hydrolase inhibitors: a patent review (2009-2014).Expert Opin Ther Pat. 2015;25(11):1247-66. DMKXZUA RU https://www.ncbi.nlm.nih.gov/pubmed/26413912 DM52683 DI DM52683 DM52683 DN Tetrazole acetic acid derivative 1 DM52683 MI TTA592U DM52683 MN Urate anion exchanger 1 (URAT1) DM52683 MT DTT DM52683 MA Inhibitor DM52683 RN Urate transporter URAT1 inhibitors: a patent review (2012 - 2015).Expert Opin Ther Pat. 2016 Jul 30:1-10. DM52683 RU https://www.ncbi.nlm.nih.gov/pubmed/27414413 DM1AGSD DI DM1AGSD DM1AGSD DN Tetrazole derivative 1 DM1AGSD MI TT473XN DM1AGSD MN P2X purinoceptor 7 (P2RX7) DM1AGSD MT DTT DM1AGSD MA Antagonist DM1AGSD RN P2X7 receptor antagonists: a patent review (2010-2015).Expert Opin Ther Pat. 2017 Mar;27(3):257-267. DM1AGSD RU https://www.ncbi.nlm.nih.gov/pubmed/27724045 DM2D4WQ DI DM2D4WQ DM2D4WQ DN Tetrazolyl urea derivative 1 DM2D4WQ MI TTDP1UC DM2D4WQ MN Fatty acid amide hydrolase (FAAH) DM2D4WQ MT DTT DM2D4WQ MA Inhibitor DM2D4WQ RN Fatty acid amide hydrolase inhibitors: a patent review (2009-2014).Expert Opin Ther Pat. 2015;25(11):1247-66. DM2D4WQ RU https://www.ncbi.nlm.nih.gov/pubmed/26413912 DMP4HR2 DI DMP4HR2 DMP4HR2 DN TG003 DMP4HR2 MI TTE6YDG DMP4HR2 MN CDC-like kinase 1 (CLK1) DMP4HR2 MT DTT DMP4HR2 MA Inhibitor DMP4HR2 RN A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases. Proc Natl Acad Sci U S A. 2007 Dec 18;104(51):20523-8. DMP4HR2 RU https://pubmed.ncbi.nlm.nih.gov/18077363 DMP4HR2 DI DMP4HR2 DMP4HR2 DN TG003 DMP4HR2 MI TT85TPS DMP4HR2 MN CDC-like kinase 2 (CLK2) DMP4HR2 MT DTT DMP4HR2 MA Inhibitor DMP4HR2 RN A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases. Proc Natl Acad Sci U S A. 2007 Dec 18;104(51):20523-8. DMP4HR2 RU https://pubmed.ncbi.nlm.nih.gov/18077363 DMP4HR2 DI DMP4HR2 DMP4HR2 DN TG003 DMP4HR2 MI TTSBVFO DMP4HR2 MN Dual-specificity tyrosine-phosphorylation regulated kinase 1A (DYRK1A) DMP4HR2 MT DTT DMP4HR2 MA Inhibitor DMP4HR2 RN Dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A) inhibitors: a survey of recent patent literature.Expert Opin Ther Pat. 2017 Nov;27(11):1183-1199. DMP4HR2 RU https://www.ncbi.nlm.nih.gov/pubmed/28766366 DM1L3ZA DI DM1L3ZA DM1L3ZA DN Thiadiazolidindione derivative 1 DM1L3ZA MI TTRZQE3 DM1L3ZA MN Glycogen synthase kinase-3 alpha (GSK-3A) DM1L3ZA MT DTT DM1L3ZA MA Inhibitor DM1L3ZA RN Glycogen synthase kinase 3 (GSK-3) inhibitors: a patent update (2014-2015).Expert Opin Ther Pat. 2017 Jun;27(6):657-666. DM1L3ZA RU https://www.ncbi.nlm.nih.gov/pubmed/27828716 DM5AUL0 DI DM5AUL0 DM5AUL0 DN Thiadiazolidindione derivative 2 DM5AUL0 MI TTRZQE3 DM5AUL0 MN Glycogen synthase kinase-3 alpha (GSK-3A) DM5AUL0 MT DTT DM5AUL0 MA Inhibitor DM5AUL0 RN Glycogen synthase kinase 3 (GSK-3) inhibitors: a patent update (2014-2015).Expert Opin Ther Pat. 2017 Jun;27(6):657-666. DM5AUL0 RU https://www.ncbi.nlm.nih.gov/pubmed/27828716 DMNTZ93 DI DMNTZ93 DMNTZ93 DN Thiadiazolidindione derivative 3 DMNTZ93 MI TTRZQE3 DMNTZ93 MN Glycogen synthase kinase-3 alpha (GSK-3A) DMNTZ93 MT DTT DMNTZ93 MA Inhibitor DMNTZ93 RN Glycogen synthase kinase 3 (GSK-3) inhibitors: a patent update (2014-2015).Expert Opin Ther Pat. 2017 Jun;27(6):657-666. DMNTZ93 RU https://www.ncbi.nlm.nih.gov/pubmed/27828716 DMX93AI DI DMX93AI DMX93AI DN Thiadiazolyl carboxamide derivative 1 DMX93AI MI TTTDVOJ DMX93AI MN Tropomyosin-related kinase A (TrkA) DMX93AI MT DTT DMX93AI MA Inhibitor DMX93AI RN Tropomyosin receptor kinase inhibitors: an updated patent review for 2010-2016 - Part I.Expert Opin Ther Pat. 2017 Jun;27(6):733-751. DMX93AI RU https://www.ncbi.nlm.nih.gov/pubmed/28270010 DMW62LX DI DMW62LX DMW62LX DN Thiazole carboxamide derivative 1 DMW62LX MI TTCZOF2 DMW62LX MN Pyruvate dehydrogenase kinase 1 (PDHK1) DMW62LX MT DTT DMW62LX MA Inhibitor DMW62LX RN PDK1 disruptors and modulators: a patent review.Expert Opin Ther Pat. 2015 May;25(5):513-37. DMW62LX RU https://www.ncbi.nlm.nih.gov/pubmed/25684022 DMWKI89 DI DMWKI89 DMWKI89 DN Thiazole carboxamide derivative 10 DMWKI89 MI TTCZOF2 DMWKI89 MN Pyruvate dehydrogenase kinase 1 (PDHK1) DMWKI89 MT DTT DMWKI89 MA Inhibitor DMWKI89 RN PDK1 disruptors and modulators: a patent review.Expert Opin Ther Pat. 2015 May;25(5):513-37. DMWKI89 RU https://www.ncbi.nlm.nih.gov/pubmed/25684022 DM0Q3HF DI DM0Q3HF DM0Q3HF DN Thiazole carboxamide derivative 11 DM0Q3HF MI TTCZOF2 DM0Q3HF MN Pyruvate dehydrogenase kinase 1 (PDHK1) DM0Q3HF MT DTT DM0Q3HF MA Inhibitor DM0Q3HF RN PDK1 disruptors and modulators: a patent review.Expert Opin Ther Pat. 2015 May;25(5):513-37. DM0Q3HF RU https://www.ncbi.nlm.nih.gov/pubmed/25684022 DMG0H73 DI DMG0H73 DMG0H73 DN Thiazole carboxamide derivative 12 DMG0H73 MI TTCZOF2 DMG0H73 MN Pyruvate dehydrogenase kinase 1 (PDHK1) DMG0H73 MT DTT DMG0H73 MA Inhibitor DMG0H73 RN PDK1 disruptors and modulators: a patent review.Expert Opin Ther Pat. 2015 May;25(5):513-37. DMG0H73 RU https://www.ncbi.nlm.nih.gov/pubmed/25684022 DMHQCEJ DI DMHQCEJ DMHQCEJ DN Thiazole carboxamide derivative 13 DMHQCEJ MI TTCZOF2 DMHQCEJ MN Pyruvate dehydrogenase kinase 1 (PDHK1) DMHQCEJ MT DTT DMHQCEJ MA Inhibitor DMHQCEJ RN PDK1 disruptors and modulators: a patent review.Expert Opin Ther Pat. 2015 May;25(5):513-37. DMHQCEJ RU https://www.ncbi.nlm.nih.gov/pubmed/25684022 DMMKNP7 DI DMMKNP7 DMMKNP7 DN Thiazole carboxamide derivative 14 DMMKNP7 MI TTCZOF2 DMMKNP7 MN Pyruvate dehydrogenase kinase 1 (PDHK1) DMMKNP7 MT DTT DMMKNP7 MA Inhibitor DMMKNP7 RN PDK1 disruptors and modulators: a patent review.Expert Opin Ther Pat. 2015 May;25(5):513-37. DMMKNP7 RU https://www.ncbi.nlm.nih.gov/pubmed/25684022 DMCH1DL DI DMCH1DL DMCH1DL DN Thiazole carboxamide derivative 15 DMCH1DL MI TTCZOF2 DMCH1DL MN Pyruvate dehydrogenase kinase 1 (PDHK1) DMCH1DL MT DTT DMCH1DL MA Inhibitor DMCH1DL RN PDK1 disruptors and modulators: a patent review.Expert Opin Ther Pat. 2015 May;25(5):513-37. DMCH1DL RU https://www.ncbi.nlm.nih.gov/pubmed/25684022 DMJQBVH DI DMJQBVH DMJQBVH DN Thiazole carboxamide derivative 16 DMJQBVH MI TTCZOF2 DMJQBVH MN Pyruvate dehydrogenase kinase 1 (PDHK1) DMJQBVH MT DTT DMJQBVH MA Inhibitor DMJQBVH RN PDK1 disruptors and modulators: a patent review.Expert Opin Ther Pat. 2015 May;25(5):513-37. DMJQBVH RU https://www.ncbi.nlm.nih.gov/pubmed/25684022 DMPMN92 DI DMPMN92 DMPMN92 DN Thiazole carboxamide derivative 17 DMPMN92 MI TTCZOF2 DMPMN92 MN Pyruvate dehydrogenase kinase 1 (PDHK1) DMPMN92 MT DTT DMPMN92 MA Inhibitor DMPMN92 RN PDK1 disruptors and modulators: a patent review.Expert Opin Ther Pat. 2015 May;25(5):513-37. DMPMN92 RU https://www.ncbi.nlm.nih.gov/pubmed/25684022 DM987MK DI DM987MK DM987MK DN Thiazole carboxamide derivative 18 DM987MK MI TTCZOF2 DM987MK MN Pyruvate dehydrogenase kinase 1 (PDHK1) DM987MK MT DTT DM987MK MA Inhibitor DM987MK RN PDK1 disruptors and modulators: a patent review.Expert Opin Ther Pat. 2015 May;25(5):513-37. DM987MK RU https://www.ncbi.nlm.nih.gov/pubmed/25684022 DMW59Q4 DI DMW59Q4 DMW59Q4 DN Thiazole carboxamide derivative 19 DMW59Q4 MI TTCZOF2 DMW59Q4 MN Pyruvate dehydrogenase kinase 1 (PDHK1) DMW59Q4 MT DTT DMW59Q4 MA Inhibitor DMW59Q4 RN PDK1 disruptors and modulators: a patent review.Expert Opin Ther Pat. 2015 May;25(5):513-37. DMW59Q4 RU https://www.ncbi.nlm.nih.gov/pubmed/25684022 DMLIRGM DI DMLIRGM DMLIRGM DN Thiazole carboxamide derivative 2 DMLIRGM MI TTCZOF2 DMLIRGM MN Pyruvate dehydrogenase kinase 1 (PDHK1) DMLIRGM MT DTT DMLIRGM MA Inhibitor DMLIRGM RN PDK1 disruptors and modulators: a patent review.Expert Opin Ther Pat. 2015 May;25(5):513-37. DMLIRGM RU https://www.ncbi.nlm.nih.gov/pubmed/25684022 DMORSH9 DI DMORSH9 DMORSH9 DN Thiazole carboxamide derivative 20 DMORSH9 MI TTCZOF2 DMORSH9 MN Pyruvate dehydrogenase kinase 1 (PDHK1) DMORSH9 MT DTT DMORSH9 MA Inhibitor DMORSH9 RN PDK1 disruptors and modulators: a patent review.Expert Opin Ther Pat. 2015 May;25(5):513-37. DMORSH9 RU https://www.ncbi.nlm.nih.gov/pubmed/25684022 DMTJBCG DI DMTJBCG DMTJBCG DN Thiazole carboxamide derivative 21 DMTJBCG MI TTCZOF2 DMTJBCG MN Pyruvate dehydrogenase kinase 1 (PDHK1) DMTJBCG MT DTT DMTJBCG MA Inhibitor DMTJBCG RN PDK1 disruptors and modulators: a patent review.Expert Opin Ther Pat. 2015 May;25(5):513-37. DMTJBCG RU https://www.ncbi.nlm.nih.gov/pubmed/25684022 DM6WTR2 DI DM6WTR2 DM6WTR2 DN Thiazole carboxamide derivative 22 DM6WTR2 MI TTCZOF2 DM6WTR2 MN Pyruvate dehydrogenase kinase 1 (PDHK1) DM6WTR2 MT DTT DM6WTR2 MA Inhibitor DM6WTR2 RN PDK1 disruptors and modulators: a patent review.Expert Opin Ther Pat. 2015 May;25(5):513-37. DM6WTR2 RU https://www.ncbi.nlm.nih.gov/pubmed/25684022 DMMO6JY DI DMMO6JY DMMO6JY DN Thiazole carboxamide derivative 23 DMMO6JY MI TTCZOF2 DMMO6JY MN Pyruvate dehydrogenase kinase 1 (PDHK1) DMMO6JY MT DTT DMMO6JY MA Inhibitor DMMO6JY RN PDK1 disruptors and modulators: a patent review.Expert Opin Ther Pat. 2015 May;25(5):513-37. DMMO6JY RU https://www.ncbi.nlm.nih.gov/pubmed/25684022 DMZ6YB0 DI DMZ6YB0 DMZ6YB0 DN Thiazole carboxamide derivative 24 DMZ6YB0 MI TTCZOF2 DMZ6YB0 MN Pyruvate dehydrogenase kinase 1 (PDHK1) DMZ6YB0 MT DTT DMZ6YB0 MA Inhibitor DMZ6YB0 RN PDK1 disruptors and modulators: a patent review.Expert Opin Ther Pat. 2015 May;25(5):513-37. DMZ6YB0 RU https://www.ncbi.nlm.nih.gov/pubmed/25684022 DMLRTFX DI DMLRTFX DMLRTFX DN Thiazole carboxamide derivative 25 DMLRTFX MI TTCZOF2 DMLRTFX MN Pyruvate dehydrogenase kinase 1 (PDHK1) DMLRTFX MT DTT DMLRTFX MA Inhibitor DMLRTFX RN PDK1 disruptors and modulators: a patent review.Expert Opin Ther Pat. 2015 May;25(5):513-37. DMLRTFX RU https://www.ncbi.nlm.nih.gov/pubmed/25684022 DM8DHZ4 DI DM8DHZ4 DM8DHZ4 DN Thiazole carboxamide derivative 26 DM8DHZ4 MI TTCZOF2 DM8DHZ4 MN Pyruvate dehydrogenase kinase 1 (PDHK1) DM8DHZ4 MT DTT DM8DHZ4 MA Inhibitor DM8DHZ4 RN PDK1 disruptors and modulators: a patent review.Expert Opin Ther Pat. 2015 May;25(5):513-37. DM8DHZ4 RU https://www.ncbi.nlm.nih.gov/pubmed/25684022 DMV30QO DI DMV30QO DMV30QO DN Thiazole carboxamide derivative 27 DMV30QO MI TTCZOF2 DMV30QO MN Pyruvate dehydrogenase kinase 1 (PDHK1) DMV30QO MT DTT DMV30QO MA Inhibitor DMV30QO RN PDK1 disruptors and modulators: a patent review.Expert Opin Ther Pat. 2015 May;25(5):513-37. DMV30QO RU https://www.ncbi.nlm.nih.gov/pubmed/25684022 DMGEIZV DI DMGEIZV DMGEIZV DN Thiazole carboxamide derivative 28 DMGEIZV MI TTCZOF2 DMGEIZV MN Pyruvate dehydrogenase kinase 1 (PDHK1) DMGEIZV MT DTT DMGEIZV MA Inhibitor DMGEIZV RN PDK1 disruptors and modulators: a patent review.Expert Opin Ther Pat. 2015 May;25(5):513-37. DMGEIZV RU https://www.ncbi.nlm.nih.gov/pubmed/25684022 DMCRVO5 DI DMCRVO5 DMCRVO5 DN Thiazole carboxamide derivative 29 DMCRVO5 MI TTCZOF2 DMCRVO5 MN Pyruvate dehydrogenase kinase 1 (PDHK1) DMCRVO5 MT DTT DMCRVO5 MA Inhibitor DMCRVO5 RN PDK1 disruptors and modulators: a patent review.Expert Opin Ther Pat. 2015 May;25(5):513-37. DMCRVO5 RU https://www.ncbi.nlm.nih.gov/pubmed/25684022 DMLRA3C DI DMLRA3C DMLRA3C DN Thiazole carboxamide derivative 3 DMLRA3C MI TTCZOF2 DMLRA3C MN Pyruvate dehydrogenase kinase 1 (PDHK1) DMLRA3C MT DTT DMLRA3C MA Inhibitor DMLRA3C RN PDK1 disruptors and modulators: a patent review.Expert Opin Ther Pat. 2015 May;25(5):513-37. DMLRA3C RU https://www.ncbi.nlm.nih.gov/pubmed/25684022 DMEOKCB DI DMEOKCB DMEOKCB DN Thiazole carboxamide derivative 30 DMEOKCB MI TTCZOF2 DMEOKCB MN Pyruvate dehydrogenase kinase 1 (PDHK1) DMEOKCB MT DTT DMEOKCB MA Inhibitor DMEOKCB RN PDK1 disruptors and modulators: a patent review.Expert Opin Ther Pat. 2015 May;25(5):513-37. DMEOKCB RU https://www.ncbi.nlm.nih.gov/pubmed/25684022 DMI3X14 DI DMI3X14 DMI3X14 DN Thiazole carboxamide derivative 4 DMI3X14 MI TTCZOF2 DMI3X14 MN Pyruvate dehydrogenase kinase 1 (PDHK1) DMI3X14 MT DTT DMI3X14 MA Inhibitor DMI3X14 RN PDK1 disruptors and modulators: a patent review.Expert Opin Ther Pat. 2015 May;25(5):513-37. DMI3X14 RU https://www.ncbi.nlm.nih.gov/pubmed/25684022 DM2H95E DI DM2H95E DM2H95E DN Thiazole carboxamide derivative 5 DM2H95E MI TTCZOF2 DM2H95E MN Pyruvate dehydrogenase kinase 1 (PDHK1) DM2H95E MT DTT DM2H95E MA Inhibitor DM2H95E RN PDK1 disruptors and modulators: a patent review.Expert Opin Ther Pat. 2015 May;25(5):513-37. DM2H95E RU https://www.ncbi.nlm.nih.gov/pubmed/25684022 DMWHCOE DI DMWHCOE DMWHCOE DN Thiazole carboxamide derivative 6 DMWHCOE MI TTCZOF2 DMWHCOE MN Pyruvate dehydrogenase kinase 1 (PDHK1) DMWHCOE MT DTT DMWHCOE MA Inhibitor DMWHCOE RN PDK1 disruptors and modulators: a patent review.Expert Opin Ther Pat. 2015 May;25(5):513-37. DMWHCOE RU https://www.ncbi.nlm.nih.gov/pubmed/25684022 DMLBK8V DI DMLBK8V DMLBK8V DN Thiazole carboxamide derivative 7 DMLBK8V MI TTCZOF2 DMLBK8V MN Pyruvate dehydrogenase kinase 1 (PDHK1) DMLBK8V MT DTT DMLBK8V MA Inhibitor DMLBK8V RN PDK1 disruptors and modulators: a patent review.Expert Opin Ther Pat. 2015 May;25(5):513-37. DMLBK8V RU https://www.ncbi.nlm.nih.gov/pubmed/25684022 DMVOTKN DI DMVOTKN DMVOTKN DN Thiazole carboxamide derivative 8 DMVOTKN MI TTCZOF2 DMVOTKN MN Pyruvate dehydrogenase kinase 1 (PDHK1) DMVOTKN MT DTT DMVOTKN MA Inhibitor DMVOTKN RN PDK1 disruptors and modulators: a patent review.Expert Opin Ther Pat. 2015 May;25(5):513-37. DMVOTKN RU https://www.ncbi.nlm.nih.gov/pubmed/25684022 DM5P04R DI DM5P04R DM5P04R DN Thiazole carboxamide derivative 9 DM5P04R MI TTCZOF2 DM5P04R MN Pyruvate dehydrogenase kinase 1 (PDHK1) DM5P04R MT DTT DM5P04R MA Inhibitor DM5P04R RN PDK1 disruptors and modulators: a patent review.Expert Opin Ther Pat. 2015 May;25(5):513-37. DM5P04R RU https://www.ncbi.nlm.nih.gov/pubmed/25684022 DM2WDXV DI DM2WDXV DM2WDXV DN Thiazole derivative 1 DM2WDXV MI TTULVH8 DM2WDXV MN Tyrosinase (TYR) DM2WDXV MT DTT DM2WDXV MA Inhibitor DM2WDXV RN Tyrosinase inhibitors: a patent review (2011-2015).Expert Opin Ther Pat. 2016;26(3):347-62. DM2WDXV RU https://www.ncbi.nlm.nih.gov/pubmed/26815044 DM8ZXBS DI DM8ZXBS DM8ZXBS DN Thiazole derivative 2 DM8ZXBS MI TTA6ZN2 DM8ZXBS MN Nuclear factor erythroid 2-related factor 2 (Nrf2) DM8ZXBS MT DTT DM8ZXBS MA Inhibitor DM8ZXBS RN Recent progress in the development of small molecule Nrf2 modulators: a patent review (2012-2016).Expert Opin Ther Pat. 2017 Jul;27(7):763-785. DM8ZXBS RU https://www.ncbi.nlm.nih.gov/pubmed/28454500 DMKU51G DI DMKU51G DMKU51G DN Thiazole derivative 3 DMKU51G MI TTA6ZN2 DMKU51G MN Nuclear factor erythroid 2-related factor 2 (Nrf2) DMKU51G MT DTT DMKU51G MA Inhibitor DMKU51G RN Recent progress in the development of small molecule Nrf2 modulators: a patent review (2012-2016).Expert Opin Ther Pat. 2017 Jul;27(7):763-785. DMKU51G RU https://www.ncbi.nlm.nih.gov/pubmed/28454500 DM5UQK6 DI DM5UQK6 DM5UQK6 DN Thiazole derivative 4 DM5UQK6 MI TTTDVOJ DM5UQK6 MN Tropomyosin-related kinase A (TrkA) DM5UQK6 MT DTT DM5UQK6 MA Inhibitor DM5UQK6 RN Tropomyosin receptor kinase inhibitors: an updated patent review for 2010-2016 - Part I.Expert Opin Ther Pat. 2017 Jun;27(6):733-751. DM5UQK6 RU https://www.ncbi.nlm.nih.gov/pubmed/28270010 DMESAUL DI DMESAUL DMESAUL DN Thiazole derivative 5 DMESAUL MI TT473XN DMESAUL MN P2X purinoceptor 7 (P2RX7) DMESAUL MT DTT DMESAUL MA Antagonist DMESAUL RN P2X7 receptor antagonists: a patent review (2010-2015).Expert Opin Ther Pat. 2017 Mar;27(3):257-267. DMESAUL RU https://www.ncbi.nlm.nih.gov/pubmed/27724045 DMCPV0D DI DMCPV0D DMCPV0D DN Thiazole-fused cycloalkyl carboxamide derivative 1 DMCPV0D MI TT473XN DMCPV0D MN P2X purinoceptor 7 (P2RX7) DMCPV0D MT DTT DMCPV0D MA Antagonist DMCPV0D RN P2X7 receptor antagonists: a patent review (2010-2015).Expert Opin Ther Pat. 2017 Mar;27(3):257-267. DMCPV0D RU https://www.ncbi.nlm.nih.gov/pubmed/27724045 DM05VO6 DI DM05VO6 DM05VO6 DN Thiazolidine derivative 1 DM05VO6 MI TTULVH8 DM05VO6 MN Tyrosinase (TYR) DM05VO6 MT DTT DM05VO6 MA Inhibitor DM05VO6 RN Tyrosinase inhibitors: a patent review (2011-2015).Expert Opin Ther Pat. 2016;26(3):347-62. DM05VO6 RU https://www.ncbi.nlm.nih.gov/pubmed/26815044 DM73GNJ DI DM73GNJ DM73GNJ DN Thiazolidine derivative 2 DM73GNJ MI TTULVH8 DM73GNJ MN Tyrosinase (TYR) DM73GNJ MT DTT DM73GNJ MA Inhibitor DM73GNJ RN Tyrosinase inhibitors: a patent review (2011-2015).Expert Opin Ther Pat. 2016;26(3):347-62. DM73GNJ RU https://www.ncbi.nlm.nih.gov/pubmed/26815044 DMXFGTZ DI DMXFGTZ DMXFGTZ DN Thiazolidine derivative 3 DMXFGTZ MI TTULVH8 DMXFGTZ MN Tyrosinase (TYR) DMXFGTZ MT DTT DMXFGTZ MA Inhibitor DMXFGTZ RN Tyrosinase inhibitors: a patent review (2011-2015).Expert Opin Ther Pat. 2016;26(3):347-62. DMXFGTZ RU https://www.ncbi.nlm.nih.gov/pubmed/26815044 DMLBA4D DI DMLBA4D DMLBA4D DN Thiazolidine dione crystalline derivative 1 DMLBA4D MI TTZMAO3 DMLBA4D MN Peroxisome proliferator-activated receptor gamma (PPAR-gamma) DMLBA4D MT DTT DMLBA4D MA Agonist DMLBA4D RN PPAR ligands and their therapeutic applications: a patent review (2008 - 2014).Expert Opin Ther Pat. 2015 Feb;25(2):175-91. DMLBA4D RU https://www.ncbi.nlm.nih.gov/pubmed/25416646 DM86HU3 DI DM86HU3 DM86HU3 DN Thiazoline derivative 1 DM86HU3 MI TTULVH8 DM86HU3 MN Tyrosinase (TYR) DM86HU3 MT DTT DM86HU3 MA Inhibitor DM86HU3 RN Tyrosinase inhibitors: a patent review (2011-2015).Expert Opin Ther Pat. 2016;26(3):347-62. DM86HU3 RU https://www.ncbi.nlm.nih.gov/pubmed/26815044 DMXRE1V DI DMXRE1V DMXRE1V DN Thiazoline derivative 2 DMXRE1V MI TTULVH8 DMXRE1V MN Tyrosinase (TYR) DMXRE1V MT DTT DMXRE1V MA Inhibitor DMXRE1V RN Tyrosinase inhibitors: a patent review (2011-2015).Expert Opin Ther Pat. 2016;26(3):347-62. DMXRE1V RU https://www.ncbi.nlm.nih.gov/pubmed/26815044 DMAFE5R DI DMAFE5R DMAFE5R DN Thiazolopyridine derivative 1 DMAFE5R MI TTBYWP2 DMAFE5R MN TYK2 tyrosine kinase (TYK2) DMAFE5R MT DTT DMAFE5R MA Inhibitor DMAFE5R RN Inhibitors of JAK-family kinases: an update on the patent literature 2013-2015, part 2.Expert Opin Ther Pat. 2017 Feb;27(2):145-161. DMAFE5R RU https://www.ncbi.nlm.nih.gov/pubmed/27774822 DMLUPV1 DI DMLUPV1 DMLUPV1 DN Thieno[2,3-c]pyridine derivative 1 DMLUPV1 MI TTZJYKH DMLUPV1 MN Indoleamine 2,3-dioxygenase 1 (IDO1) DMLUPV1 MT DTT DMLUPV1 MA Inhibitor DMLUPV1 RN A patent review of IDO1 inhibitors for cancer.Expert Opin Ther Pat. 2018 Apr;28(4):317-330. DMLUPV1 RU https://www.ncbi.nlm.nih.gov/pubmed/29473428 DM1C8MA DI DM1C8MA DM1C8MA DN Thieno[3,2-c]pyridine-7-carboxamide derivative 1 DM1C8MA MI TTCZOF2 DM1C8MA MN Pyruvate dehydrogenase kinase 1 (PDHK1) DM1C8MA MT DTT DM1C8MA MA Inhibitor DM1C8MA RN PDK1 disruptors and modulators: a patent review.Expert Opin Ther Pat. 2015 May;25(5):513-37. DM1C8MA RU https://www.ncbi.nlm.nih.gov/pubmed/25684022 DMOWFA5 DI DMOWFA5 DMOWFA5 DN Thieno[3,2-c]pyridine-7-carboxamide derivative 2 DMOWFA5 MI TTCZOF2 DMOWFA5 MN Pyruvate dehydrogenase kinase 1 (PDHK1) DMOWFA5 MT DTT DMOWFA5 MA Inhibitor DMOWFA5 RN PDK1 disruptors and modulators: a patent review.Expert Opin Ther Pat. 2015 May;25(5):513-37. DMOWFA5 RU https://www.ncbi.nlm.nih.gov/pubmed/25684022 DMZP6KR DI DMZP6KR DMZP6KR DN Thiomorpholine derivative 1 DMZP6KR MI TTDIGC1 DMZP6KR MN Dipeptidyl peptidase 4 (DPP-4) DMZP6KR MT DTT DMZP6KR MA Inhibitor DMZP6KR RN DPP-4 inhibitors: a patent review (2012 - 2014).Expert Opin Ther Pat. 2015 Feb;25(2):209-36. DMZP6KR RU https://www.ncbi.nlm.nih.gov/pubmed/25482888 DMZP6KR DI DMZP6KR DMZP6KR DN Thiomorpholine derivative 1 DMZP6KR MI TTJGLZF DMZP6KR MN Dipeptidyl peptidase 8 (DPP-8) DMZP6KR MT DTT DMZP6KR MA Inhibitor DMZP6KR RN DPP-4 inhibitors: a patent review (2012 - 2014).Expert Opin Ther Pat. 2015 Feb;25(2):209-36. DMZP6KR RU https://www.ncbi.nlm.nih.gov/pubmed/25482888 DMZP6KR DI DMZP6KR DMZP6KR DN Thiomorpholine derivative 1 DMZP6KR MI TTNDUL7 DMZP6KR MN Dipeptidyl peptidase 9 (DPP-9) DMZP6KR MT DTT DMZP6KR MA Inhibitor DMZP6KR RN DPP-4 inhibitors: a patent review (2012 - 2014).Expert Opin Ther Pat. 2015 Feb;25(2):209-36. DMZP6KR RU https://www.ncbi.nlm.nih.gov/pubmed/25482888 DMWOK1D DI DMWOK1D DMWOK1D DN Thiomorpholine derivative 2 DMWOK1D MI TTDIGC1 DMWOK1D MN Dipeptidyl peptidase 4 (DPP-4) DMWOK1D MT DTT DMWOK1D MA Inhibitor DMWOK1D RN DPP-4 inhibitors: a patent review (2012 - 2014).Expert Opin Ther Pat. 2015 Feb;25(2):209-36. DMWOK1D RU https://www.ncbi.nlm.nih.gov/pubmed/25482888 DMWOK1D DI DMWOK1D DMWOK1D DN Thiomorpholine derivative 2 DMWOK1D MI TTJGLZF DMWOK1D MN Dipeptidyl peptidase 8 (DPP-8) DMWOK1D MT DTT DMWOK1D MA Inhibitor DMWOK1D RN DPP-4 inhibitors: a patent review (2012 - 2014).Expert Opin Ther Pat. 2015 Feb;25(2):209-36. DMWOK1D RU https://www.ncbi.nlm.nih.gov/pubmed/25482888 DMWOK1D DI DMWOK1D DMWOK1D DN Thiomorpholine derivative 2 DMWOK1D MI TTNDUL7 DMWOK1D MN Dipeptidyl peptidase 9 (DPP-9) DMWOK1D MT DTT DMWOK1D MA Inhibitor DMWOK1D RN DPP-4 inhibitors: a patent review (2012 - 2014).Expert Opin Ther Pat. 2015 Feb;25(2):209-36. DMWOK1D RU https://www.ncbi.nlm.nih.gov/pubmed/25482888 DM6QHO0 DI DM6QHO0 DM6QHO0 DN Tihoacetate derivative 1 DM6QHO0 MI TTA592U DM6QHO0 MN Urate anion exchanger 1 (URAT1) DM6QHO0 MT DTT DM6QHO0 MA Inhibitor DM6QHO0 RN Urate transporter URAT1 inhibitors: a patent review (2012 - 2015).Expert Opin Ther Pat. 2016 Jul 30:1-10. DM6QHO0 RU https://www.ncbi.nlm.nih.gov/pubmed/27414413 DM5UI73 DI DM5UI73 DM5UI73 DN Tihotungstate derivative 1 DM5UI73 MI TTSXVID DM5UI73 MN Nuclear factor NF-kappa-B (NFKB) DM5UI73 MT DTT DM5UI73 MA Inhibitor DM5UI73 RN Novel NF-B inhibitors: a patent review (2011 - 2014).Expert Opin Ther Pat. 2015 Mar;25(3):319-34. DM5UI73 RU https://www.ncbi.nlm.nih.gov/pubmed/25553724 DMGR6IJ DI DMGR6IJ DMGR6IJ DN Tihourea derivative 1 DMGR6IJ MI TTSXVID DMGR6IJ MN Nuclear factor NF-kappa-B (NFKB) DMGR6IJ MT DTT DMGR6IJ MA Inhibitor DMGR6IJ RN Novel NF-B inhibitors: a patent review (2011 - 2014).Expert Opin Ther Pat. 2015 Mar;25(3):319-34. DMGR6IJ RU https://www.ncbi.nlm.nih.gov/pubmed/25553724 DMHR43K DI DMHR43K DMHR43K DN Tlouidine sulfonamide derivative 1 DMHR43K MI TTUX68I DMHR43K MN Hypoxia-inducible factor 1 (HIF-1) DMHR43K MT DTT DMHR43K MA Inhibitor DMHR43K RN Hypoxia-inducible factor (HIF) inhibitors: a patent survey (2011-2015).Expert Opin Ther Pat. 2016;26(3):309-22. DMHR43K RU https://www.ncbi.nlm.nih.gov/pubmed/26882240 DM6KJLG DI DM6KJLG DM6KJLG DN Trepenoid derivative 1 DM6KJLG MI TT3Z6Y9 DM6KJLG MN Cysteines of Keap1 (KEAP1 Cysteines) DM6KJLG MT DTT DM6KJLG MA Modulator DM6KJLG RN Recent progress in the development of small molecule Nrf2 modulators: a patent review (2012-2016).Expert Opin Ther Pat. 2017 Jul;27(7):763-785. DM6KJLG RU https://www.ncbi.nlm.nih.gov/pubmed/28454500 DM6KJLG DI DM6KJLG DM6KJLG DN Trepenoid derivative 1 DM6KJLG MI TTA6ZN2 DM6KJLG MN Nuclear factor erythroid 2-related factor 2 (Nrf2) DM6KJLG MT DTT DM6KJLG MA Activator DM6KJLG RN Recent progress in the development of small molecule Nrf2 modulators: a patent review (2012-2016).Expert Opin Ther Pat. 2017 Jul;27(7):763-785. DM6KJLG RU https://www.ncbi.nlm.nih.gov/pubmed/28454500 DM9QB2S DI DM9QB2S DM9QB2S DN Triazole derivative 1 DM9QB2S MI TT2F4OL DM9QB2S MN Tissue transglutaminase (TG2) DM9QB2S MT DTT DM9QB2S MA Inhibitor DM9QB2S RN Transglutaminase inhibitors: a patent review.Expert Opin Ther Pat. 2016;26(1):49-63. DM9QB2S RU https://www.ncbi.nlm.nih.gov/pubmed/26560530 DM7KNXH DI DM7KNXH DM7KNXH DN Triazole derivative 2 DM7KNXH MI TT473XN DM7KNXH MN P2X purinoceptor 7 (P2RX7) DM7KNXH MT DTT DM7KNXH MA Antagonist DM7KNXH RN P2X7 receptor antagonists: a patent review (2010-2015).Expert Opin Ther Pat. 2017 Mar;27(3):257-267. DM7KNXH RU https://www.ncbi.nlm.nih.gov/pubmed/27724045 DMZR0TH DI DMZR0TH DMZR0TH DN Triazole derivative 3 DMZR0TH MI TTN9T81 DMZR0TH MN Arachidonate 15-lipoxygenase (15-LOX) DMZR0TH MT DTT DMZR0TH MA Inhibitor DMZR0TH RN 15-Lipoxygenase inhibitors: a patent review.Expert Opin Ther Pat. 2016;26(1):65-88. DMZR0TH RU https://www.ncbi.nlm.nih.gov/pubmed/26560362 DMCFEAS DI DMCFEAS DMCFEAS DN Triazole derivative 4 DMCFEAS MI TTSCIUP DMCFEAS MN Oxytocin receptor (OTR) DMCFEAS MT DTT DMCFEAS MA Antagonist DMCFEAS RN A patent review of oxytocin receptor antagonists 2013-2017.Expert Opin Ther Pat. 2017 Dec;27(12):1287-1290. DMCFEAS RU https://www.ncbi.nlm.nih.gov/pubmed/28906174 DMA83QK DI DMA83QK DMA83QK DN Triazole derivative 5 DMA83QK MI TTSCIUP DMA83QK MN Oxytocin receptor (OTR) DMA83QK MT DTT DMA83QK MA Antagonist DMA83QK RN A patent review of oxytocin receptor antagonists 2013-2017.Expert Opin Ther Pat. 2017 Dec;27(12):1287-1290. DMA83QK RU https://www.ncbi.nlm.nih.gov/pubmed/28906174 DMU15FW DI DMU15FW DMU15FW DN Triazole derivative 6 DMU15FW MI TTSCIUP DMU15FW MN Oxytocin receptor (OTR) DMU15FW MT DTT DMU15FW MA Antagonist DMU15FW RN A patent review of oxytocin receptor antagonists 2013-2017.Expert Opin Ther Pat. 2017 Dec;27(12):1287-1290. DMU15FW RU https://www.ncbi.nlm.nih.gov/pubmed/28906174 DMRK4AT DI DMRK4AT DMRK4AT DN Triazole derivative 7 DMRK4AT MI TTSCIUP DMRK4AT MN Oxytocin receptor (OTR) DMRK4AT MT DTT DMRK4AT MA Antagonist DMRK4AT RN A patent review of oxytocin receptor antagonists 2013-2017.Expert Opin Ther Pat. 2017 Dec;27(12):1287-1290. DMRK4AT RU https://www.ncbi.nlm.nih.gov/pubmed/28906174 DMCWES7 DI DMCWES7 DMCWES7 DN Triazole gold complexe 1 DMCWES7 MI TTR7UJ3 DMCWES7 MN Cytoplasmic thioredoxin reductase (TXNRD1) DMCWES7 MT DTT DMCWES7 MA Inhibitor DMCWES7 RN Thioredoxin reductase inhibitors: a patent review.Expert Opin Ther Pat. 2017 May;27(5):547-556. DMCWES7 RU https://www.ncbi.nlm.nih.gov/pubmed/27977313 DMJON7D DI DMJON7D DMJON7D DN Triazole gold complexe 2 DMJON7D MI TTR7UJ3 DMJON7D MN Cytoplasmic thioredoxin reductase (TXNRD1) DMJON7D MT DTT DMJON7D MA Inhibitor DMJON7D RN Thioredoxin reductase inhibitors: a patent review.Expert Opin Ther Pat. 2017 May;27(5):547-556. DMJON7D RU https://www.ncbi.nlm.nih.gov/pubmed/27977313 DM5TILQ DI DM5TILQ DM5TILQ DN Triazole gold complexe 3 DM5TILQ MI TTR7UJ3 DM5TILQ MN Cytoplasmic thioredoxin reductase (TXNRD1) DM5TILQ MT DTT DM5TILQ MA Inhibitor DM5TILQ RN Thioredoxin reductase inhibitors: a patent review.Expert Opin Ther Pat. 2017 May;27(5):547-556. DM5TILQ RU https://www.ncbi.nlm.nih.gov/pubmed/27977313 DMPRGLZ DI DMPRGLZ DMPRGLZ DN Triazole piperazine derivative 1 DMPRGLZ MI TTDIGC1 DMPRGLZ MN Dipeptidyl peptidase 4 (DPP-4) DMPRGLZ MT DTT DMPRGLZ MA Inhibitor DMPRGLZ RN DPP-4 inhibitors: a patent review (2012 - 2014).Expert Opin Ther Pat. 2015 Feb;25(2):209-36. DMPRGLZ RU https://www.ncbi.nlm.nih.gov/pubmed/25482888 DM8LFGS DI DM8LFGS DM8LFGS DN Triazole propanedioic acid derivative 1 DM8LFGS MI TTA592U DM8LFGS MN Urate anion exchanger 1 (URAT1) DM8LFGS MT DTT DM8LFGS MA Inhibitor DM8LFGS RN Urate transporter URAT1 inhibitors: a patent review (2012 - 2015).Expert Opin Ther Pat. 2016 Jul 30:1-10. DM8LFGS RU https://www.ncbi.nlm.nih.gov/pubmed/27414413 DM34MCP DI DM34MCP DM34MCP DN Triazolo[4,3-b]pyridazine derivative 1 DM34MCP MI TTSCO7R DM34MCP MN NAD-dependent deacetylase sirtuin (SIRT) DM34MCP MT DTT DM34MCP MA Inhibitor DM34MCP RN Sirtuin modulators: an updated patent review (2012 - 2014).Expert Opin Ther Pat. 2015 Jan;25(1):5-15. DM34MCP RU https://www.ncbi.nlm.nih.gov/pubmed/25435179 DMMJ1FN DI DMMJ1FN DMMJ1FN DN Triazolo[4,3-b]pyridazine derivative 2 DMMJ1FN MI TTTDVOJ DMMJ1FN MN Tropomyosin-related kinase A (TrkA) DMMJ1FN MT DTT DMMJ1FN MA Inhibitor DMMJ1FN RN Tropomyosin receptor kinase inhibitors: an updated patent review for 2010-2016 - Part II.Expert Opin Ther Pat. 2017 Jul;27(7):831-849. DMMJ1FN RU https://www.ncbi.nlm.nih.gov/pubmed/28270021 DM79KEX DI DM79KEX DM79KEX DN Triazolo-benzodiazepine derivative 1 DM79KEX MI TT9JNIC DM79KEX MN Histamine H3 receptor (H3R) DM79KEX MT DTT DM79KEX MA Ligand DM79KEX RN Progress in the development of histamine H3 receptor antagonists/inverse agonists: a patent review (2013-2017).Expert Opin Ther Pat. 2018 Mar;28(3):175-196. DM79KEX RU https://www.ncbi.nlm.nih.gov/pubmed/29334795 DMQSCHA DI DMQSCHA DMQSCHA DN Triazolo-benzodiazepine derivative 2 DMQSCHA MI TT9JNIC DMQSCHA MN Histamine H3 receptor (H3R) DMQSCHA MT DTT DMQSCHA MA Ligand DMQSCHA RN Progress in the development of histamine H3 receptor antagonists/inverse agonists: a patent review (2013-2017).Expert Opin Ther Pat. 2018 Mar;28(3):175-196. DMQSCHA RU https://www.ncbi.nlm.nih.gov/pubmed/29334795 DMU9A7V DI DMU9A7V DMU9A7V DN Triazolo-phthalazine derivative 1 DMU9A7V MI TTJGW1Z DMU9A7V MN Phosphodiesterase 2A (PDE2A) DMU9A7V MT DTT DMU9A7V MA Inhibitor DMU9A7V RN Towards selective phosphodiesterase 2A (PDE2A) inhibitors: a patent review (2010 - present).Expert Opin Ther Pat. 2016 Aug;26(8):933-46. DMU9A7V RU https://www.ncbi.nlm.nih.gov/pubmed/27321640 DM1KHGY DI DM1KHGY DM1KHGY DN Triazolo-pyrazinone derivative 1 DM1KHGY MI TT473XN DM1KHGY MN P2X purinoceptor 7 (P2RX7) DM1KHGY MT DTT DM1KHGY MA Antagonist DM1KHGY RN P2X7 receptor antagonists: a patent review (2010-2015).Expert Opin Ther Pat. 2017 Mar;27(3):257-267. DM1KHGY RU https://www.ncbi.nlm.nih.gov/pubmed/27724045 DM0Q9VY DI DM0Q9VY DM0Q9VY DN Triazolo-pyridine derivative 1 DM0Q9VY MI TT6DM01 DM0Q9VY MN Janus kinase 1 (JAK-1) DM0Q9VY MT DTT DM0Q9VY MA Inhibitor DM0Q9VY RN Inhibitors of JAK-family kinases: an update on the patent literature 2013-2015, part 2.Expert Opin Ther Pat. 2017 Feb;27(2):145-161. DM0Q9VY RU https://www.ncbi.nlm.nih.gov/pubmed/27774822 DM0Q9VY DI DM0Q9VY DM0Q9VY DN Triazolo-pyridine derivative 1 DM0Q9VY MI TTRMX3V DM0Q9VY MN Janus kinase 2 (JAK-2) DM0Q9VY MT DTT DM0Q9VY MA Inhibitor DM0Q9VY RN Inhibitors of JAK-family kinases: an update on the patent literature 2013-2015, part 2.Expert Opin Ther Pat. 2017 Feb;27(2):145-161. DM0Q9VY RU https://www.ncbi.nlm.nih.gov/pubmed/27774822 DMXPQ24 DI DMXPQ24 DMXPQ24 DN Triazolo-pyridine derivative 2 DMXPQ24 MI TTJW4LU DMXPQ24 MN Phosphodiesterase 10A (PDE10) DMXPQ24 MT DTT DMXPQ24 MA Inhibitor DMXPQ24 RN Towards selective phosphodiesterase 2A (PDE2A) inhibitors: a patent review (2010 - present).Expert Opin Ther Pat. 2016 Aug;26(8):933-46. DMXPQ24 RU https://www.ncbi.nlm.nih.gov/pubmed/27321640 DMXPQ24 DI DMXPQ24 DMXPQ24 DN Triazolo-pyridine derivative 2 DMXPQ24 MI TTJGW1Z DMXPQ24 MN Phosphodiesterase 2A (PDE2A) DMXPQ24 MT DTT DMXPQ24 MA Inhibitor DMXPQ24 RN Towards selective phosphodiesterase 2A (PDE2A) inhibitors: a patent review (2010 - present).Expert Opin Ther Pat. 2016 Aug;26(8):933-46. DMXPQ24 RU https://www.ncbi.nlm.nih.gov/pubmed/27321640 DMQL1TV DI DMQL1TV DMQL1TV DN Triazolo-pyridine derivative 3 DMQL1TV MI TTJW4LU DMQL1TV MN Phosphodiesterase 10A (PDE10) DMQL1TV MT DTT DMQL1TV MA Inhibitor DMQL1TV RN Towards selective phosphodiesterase 2A (PDE2A) inhibitors: a patent review (2010 - present).Expert Opin Ther Pat. 2016 Aug;26(8):933-46. DMQL1TV RU https://www.ncbi.nlm.nih.gov/pubmed/27321640 DMQL1TV DI DMQL1TV DMQL1TV DN Triazolo-pyridine derivative 3 DMQL1TV MI TTJGW1Z DMQL1TV MN Phosphodiesterase 2A (PDE2A) DMQL1TV MT DTT DMQL1TV MA Inhibitor DMQL1TV RN Towards selective phosphodiesterase 2A (PDE2A) inhibitors: a patent review (2010 - present).Expert Opin Ther Pat. 2016 Aug;26(8):933-46. DMQL1TV RU https://www.ncbi.nlm.nih.gov/pubmed/27321640 DM5ZQKS DI DM5ZQKS DM5ZQKS DN Triazolo-pyridine derivative 4 DM5ZQKS MI TTJW4LU DM5ZQKS MN Phosphodiesterase 10A (PDE10) DM5ZQKS MT DTT DM5ZQKS MA Inhibitor DM5ZQKS RN Towards selective phosphodiesterase 2A (PDE2A) inhibitors: a patent review (2010 - present).Expert Opin Ther Pat. 2016 Aug;26(8):933-46. DM5ZQKS RU https://www.ncbi.nlm.nih.gov/pubmed/27321640 DM5ZQKS DI DM5ZQKS DM5ZQKS DN Triazolo-pyridine derivative 4 DM5ZQKS MI TTJGW1Z DM5ZQKS MN Phosphodiesterase 2A (PDE2A) DM5ZQKS MT DTT DM5ZQKS MA Inhibitor DM5ZQKS RN Towards selective phosphodiesterase 2A (PDE2A) inhibitors: a patent review (2010 - present).Expert Opin Ther Pat. 2016 Aug;26(8):933-46. DM5ZQKS RU https://www.ncbi.nlm.nih.gov/pubmed/27321640 DM1R205 DI DM1R205 DM1R205 DN Triazolo-pyridine derivative 5 DM1R205 MI TTJW4LU DM1R205 MN Phosphodiesterase 10A (PDE10) DM1R205 MT DTT DM1R205 MA Inhibitor DM1R205 RN Towards selective phosphodiesterase 2A (PDE2A) inhibitors: a patent review (2010 - present).Expert Opin Ther Pat. 2016 Aug;26(8):933-46. DM1R205 RU https://www.ncbi.nlm.nih.gov/pubmed/27321640 DM1R205 DI DM1R205 DM1R205 DN Triazolo-pyridine derivative 5 DM1R205 MI TTJGW1Z DM1R205 MN Phosphodiesterase 2A (PDE2A) DM1R205 MT DTT DM1R205 MA Inhibitor DM1R205 RN Towards selective phosphodiesterase 2A (PDE2A) inhibitors: a patent review (2010 - present).Expert Opin Ther Pat. 2016 Aug;26(8):933-46. DM1R205 RU https://www.ncbi.nlm.nih.gov/pubmed/27321640 DMX4WFP DI DMX4WFP DMX4WFP DN Triazolo-pyridine derivative 6 DMX4WFP MI TTJW4LU DMX4WFP MN Phosphodiesterase 10A (PDE10) DMX4WFP MT DTT DMX4WFP MA Inhibitor DMX4WFP RN Towards selective phosphodiesterase 2A (PDE2A) inhibitors: a patent review (2010 - present).Expert Opin Ther Pat. 2016 Aug;26(8):933-46. DMX4WFP RU https://www.ncbi.nlm.nih.gov/pubmed/27321640 DMX4WFP DI DMX4WFP DMX4WFP DN Triazolo-pyridine derivative 6 DMX4WFP MI TTJGW1Z DMX4WFP MN Phosphodiesterase 2A (PDE2A) DMX4WFP MT DTT DMX4WFP MA Inhibitor DMX4WFP RN Towards selective phosphodiesterase 2A (PDE2A) inhibitors: a patent review (2010 - present).Expert Opin Ther Pat. 2016 Aug;26(8):933-46. DMX4WFP RU https://www.ncbi.nlm.nih.gov/pubmed/27321640 DMJN72E DI DMJN72E DMJN72E DN Triazolo-pyrimidinedione derivative 1 DMJN72E MI TTDIGC1 DMJN72E MN Dipeptidyl peptidase 4 (DPP-4) DMJN72E MT DTT DMJN72E MA Inhibitor DMJN72E RN DPP-4 inhibitors: a patent review (2012 - 2014).Expert Opin Ther Pat. 2015 Feb;25(2):209-36. DMJN72E RU https://www.ncbi.nlm.nih.gov/pubmed/25482888 DMLGNB2 DI DMLGNB2 DMLGNB2 DN Triazolo-pyrimidinedione derivative 2 DMLGNB2 MI TTDIGC1 DMLGNB2 MN Dipeptidyl peptidase 4 (DPP-4) DMLGNB2 MT DTT DMLGNB2 MA Inhibitor DMLGNB2 RN DPP-4 inhibitors: a patent review (2012 - 2014).Expert Opin Ther Pat. 2015 Feb;25(2):209-36. DMLGNB2 RU https://www.ncbi.nlm.nih.gov/pubmed/25482888 DMYEDJI DI DMYEDJI DMYEDJI DN Tricyclic 5-quinolone derivative 1 DMYEDJI MI TTRZQE3 DMYEDJI MN Glycogen synthase kinase-3 alpha (GSK-3A) DMYEDJI MT DTT DMYEDJI MA Inhibitor DMYEDJI RN Glycogen synthase kinase 3 (GSK-3) inhibitors: a patent update (2014-2015).Expert Opin Ther Pat. 2017 Jun;27(6):657-666. DMYEDJI RU https://www.ncbi.nlm.nih.gov/pubmed/27828716 DM5SD9E DI DM5SD9E DM5SD9E DN Tricyclic benzimidazole derivative 1 DM5SD9E MI TTH6V3D DM5SD9E MN Cyclin-dependent kinase 1 (CDK1) DM5SD9E MT DTT DM5SD9E MA Inhibitor DM5SD9E RN Cyclin-dependent kinase inhibitors for cancer therapy: a patent review (2009 - 2014).Expert Opin Ther Pat. 2015;25(9):953-70. DM5SD9E RU https://www.ncbi.nlm.nih.gov/pubmed/26161698 DM5SD9E DI DM5SD9E DM5SD9E DN Tricyclic benzimidazole derivative 1 DM5SD9E MI TTL4Q97 DM5SD9E MN Cyclin-dependent kinase 5 (CDK5) DM5SD9E MT DTT DM5SD9E MA Inhibitor DM5SD9E RN Cyclin-dependent kinase inhibitors for cancer therapy: a patent review (2009 - 2014).Expert Opin Ther Pat. 2015;25(9):953-70. DM5SD9E RU https://www.ncbi.nlm.nih.gov/pubmed/26161698 DM5SD9E DI DM5SD9E DM5SD9E DN Tricyclic benzimidazole derivative 1 DM5SD9E MI TTQYF7G DM5SD9E MN Cyclin-dependent kinase 7 (CDK7) DM5SD9E MT DTT DM5SD9E MA Inhibitor DM5SD9E RN Cyclin-dependent kinase inhibitors for cancer therapy: a patent review (2009 - 2014).Expert Opin Ther Pat. 2015;25(9):953-70. DM5SD9E RU https://www.ncbi.nlm.nih.gov/pubmed/26161698 DM5SD9E DI DM5SD9E DM5SD9E DN Tricyclic benzimidazole derivative 1 DM5SD9E MI TTBJR4L DM5SD9E MN Cyclin-dependent kinase 8 (CDK8) DM5SD9E MT DTT DM5SD9E MA Inhibitor DM5SD9E RN Cyclin-dependent kinase inhibitors for cancer therapy: a patent review (2009 - 2014).Expert Opin Ther Pat. 2015;25(9):953-70. DM5SD9E RU https://www.ncbi.nlm.nih.gov/pubmed/26161698 DM5SD9E DI DM5SD9E DM5SD9E DN Tricyclic benzimidazole derivative 1 DM5SD9E MI TT1LVF2 DM5SD9E MN Cyclin-dependent kinase 9 (CDK9) DM5SD9E MT DTT DM5SD9E MA Inhibitor DM5SD9E RN Cyclin-dependent kinase inhibitors for cancer therapy: a patent review (2009 - 2014).Expert Opin Ther Pat. 2015;25(9):953-70. DM5SD9E RU https://www.ncbi.nlm.nih.gov/pubmed/26161698 DMLBR4F DI DMLBR4F DMLBR4F DN Tricyclic compound 1 DMLBR4F MI TT6DM01 DMLBR4F MN Janus kinase 1 (JAK-1) DMLBR4F MT DTT DMLBR4F MA Inhibitor DMLBR4F RN Inhibitors of JAK-family kinases: an update on the patent literature 2013-2015, part 1.Expert Opin Ther Pat. 2017 Feb;27(2):127-143. DMLBR4F RU https://www.ncbi.nlm.nih.gov/pubmed/27774824 DMLBR4F DI DMLBR4F DMLBR4F DN Tricyclic compound 1 DMLBR4F MI TTRMX3V DMLBR4F MN Janus kinase 2 (JAK-2) DMLBR4F MT DTT DMLBR4F MA Inhibitor DMLBR4F RN Inhibitors of JAK-family kinases: an update on the patent literature 2013-2015, part 1.Expert Opin Ther Pat. 2017 Feb;27(2):127-143. DMLBR4F RU https://www.ncbi.nlm.nih.gov/pubmed/27774824 DMLBR4F DI DMLBR4F DMLBR4F DN Tricyclic compound 1 DMLBR4F MI TTT7PJU DMLBR4F MN Janus kinase 3 (JAK-3) DMLBR4F MT DTT DMLBR4F MA Inhibitor DMLBR4F RN Inhibitors of JAK-family kinases: an update on the patent literature 2013-2015, part 1.Expert Opin Ther Pat. 2017 Feb;27(2):127-143. DMLBR4F RU https://www.ncbi.nlm.nih.gov/pubmed/27774824 DMV1RQX DI DMV1RQX DMV1RQX DN Tricyclic compound 10 DMV1RQX MI TTAIQSN DMV1RQX MN Receptor-interacting protein 1 (RIPK1) DMV1RQX MT DTT DMV1RQX MA Inhibitor DMV1RQX RN Necroptosis inhibitors as therapeutic targets in inflammation mediated disorders - a review of the current literature and patents.Expert Opin Ther Pat. 2016 Nov;26(11):1239-1256. DMV1RQX RU https://www.ncbi.nlm.nih.gov/pubmed/27568917 DMJAZ7D DI DMJAZ7D DMJAZ7D DN Tricyclic compound 11 DMJAZ7D MI TT6DM01 DMJAZ7D MN Janus kinase 1 (JAK-1) DMJAZ7D MT DTT DMJAZ7D MA Inhibitor DMJAZ7D RN Inhibitors of JAK-family kinases: an update on the patent literature 2013-2015, part 2.Expert Opin Ther Pat. 2017 Feb;27(2):145-161. DMJAZ7D RU https://www.ncbi.nlm.nih.gov/pubmed/27774822 DMJAZ7D DI DMJAZ7D DMJAZ7D DN Tricyclic compound 11 DMJAZ7D MI TTRMX3V DMJAZ7D MN Janus kinase 2 (JAK-2) DMJAZ7D MT DTT DMJAZ7D MA Inhibitor DMJAZ7D RN Inhibitors of JAK-family kinases: an update on the patent literature 2013-2015, part 2.Expert Opin Ther Pat. 2017 Feb;27(2):145-161. DMJAZ7D RU https://www.ncbi.nlm.nih.gov/pubmed/27774822 DMJAZ7D DI DMJAZ7D DMJAZ7D DN Tricyclic compound 11 DMJAZ7D MI TTT7PJU DMJAZ7D MN Janus kinase 3 (JAK-3) DMJAZ7D MT DTT DMJAZ7D MA Inhibitor DMJAZ7D RN Inhibitors of JAK-family kinases: an update on the patent literature 2013-2015, part 2.Expert Opin Ther Pat. 2017 Feb;27(2):145-161. DMJAZ7D RU https://www.ncbi.nlm.nih.gov/pubmed/27774822 DMJAZ7D DI DMJAZ7D DMJAZ7D DN Tricyclic compound 11 DMJAZ7D MI TTBYWP2 DMJAZ7D MN TYK2 tyrosine kinase (TYK2) DMJAZ7D MT DTT DMJAZ7D MA Inhibitor DMJAZ7D RN Inhibitors of JAK-family kinases: an update on the patent literature 2013-2015, part 2.Expert Opin Ther Pat. 2017 Feb;27(2):145-161. DMJAZ7D RU https://www.ncbi.nlm.nih.gov/pubmed/27774822 DMJAWOI DI DMJAWOI DMJAWOI DN Tricyclic compound 2 DMJAWOI MI TTT7PJU DMJAWOI MN Janus kinase 3 (JAK-3) DMJAWOI MT DTT DMJAWOI MA Inhibitor DMJAWOI RN Inhibitors of JAK-family kinases: an update on the patent literature 2013-2015, part 1.Expert Opin Ther Pat. 2017 Feb;27(2):127-143. DMJAWOI RU https://www.ncbi.nlm.nih.gov/pubmed/27774824 DM9K7P0 DI DM9K7P0 DM9K7P0 DN Tricyclic compound 3 DM9K7P0 MI TT6DM01 DM9K7P0 MN Janus kinase 1 (JAK-1) DM9K7P0 MT DTT DM9K7P0 MA Inhibitor DM9K7P0 RN Inhibitors of JAK-family kinases: an update on the patent literature 2013-2015, part 1.Expert Opin Ther Pat. 2017 Feb;27(2):127-143. DM9K7P0 RU https://www.ncbi.nlm.nih.gov/pubmed/27774824 DMEIG16 DI DMEIG16 DMEIG16 DN Tricyclic compound 4 DMEIG16 MI TTGWKQJ DMEIG16 MN Rho-associated protein kinase 2 (ROCK2) DMEIG16 MT DTT DMEIG16 MA Inhibitor DMEIG16 RN Rho kinase inhibitors: a patent review (2014 - 2016).Expert Opin Ther Pat. 2017 Apr;27(4):507-515. DMEIG16 RU https://www.ncbi.nlm.nih.gov/pubmed/28048944 DMLPMS7 DI DMLPMS7 DMLPMS7 DN Tricyclic compound 5 DMLPMS7 MI TTGWKQJ DMLPMS7 MN Rho-associated protein kinase 2 (ROCK2) DMLPMS7 MT DTT DMLPMS7 MA Inhibitor DMLPMS7 RN Rho kinase inhibitors: a patent review (2014 - 2016).Expert Opin Ther Pat. 2017 Apr;27(4):507-515. DMLPMS7 RU https://www.ncbi.nlm.nih.gov/pubmed/28048944 DMMJ81G DI DMMJ81G DMMJ81G DN Tricyclic compound 6 DMMJ81G MI TTGWKQJ DMMJ81G MN Rho-associated protein kinase 2 (ROCK2) DMMJ81G MT DTT DMMJ81G MA Inhibitor DMMJ81G RN Rho kinase inhibitors: a patent review (2014 - 2016).Expert Opin Ther Pat. 2017 Apr;27(4):507-515. DMMJ81G RU https://www.ncbi.nlm.nih.gov/pubmed/28048944 DME84S5 DI DME84S5 DME84S5 DN Tricyclic compound 7 DME84S5 MI TTGWKQJ DME84S5 MN Rho-associated protein kinase 2 (ROCK2) DME84S5 MT DTT DME84S5 MA Inhibitor DME84S5 RN Rho kinase inhibitors: a patent review (2014 - 2016).Expert Opin Ther Pat. 2017 Apr;27(4):507-515. DME84S5 RU https://www.ncbi.nlm.nih.gov/pubmed/28048944 DMZI8GK DI DMZI8GK DMZI8GK DN Tricyclic compound 8 DMZI8GK MI TTAIQSN DMZI8GK MN Receptor-interacting protein 1 (RIPK1) DMZI8GK MT DTT DMZI8GK MA Inhibitor DMZI8GK RN Necroptosis inhibitors as therapeutic targets in inflammation mediated disorders - a review of the current literature and patents.Expert Opin Ther Pat. 2016 Nov;26(11):1239-1256. DMZI8GK RU https://www.ncbi.nlm.nih.gov/pubmed/27568917 DMF5E6U DI DMF5E6U DMF5E6U DN Tricyclic compound 9 DMF5E6U MI TTAIQSN DMF5E6U MN Receptor-interacting protein 1 (RIPK1) DMF5E6U MT DTT DMF5E6U MA Inhibitor DMF5E6U RN Necroptosis inhibitors as therapeutic targets in inflammation mediated disorders - a review of the current literature and patents.Expert Opin Ther Pat. 2016 Nov;26(11):1239-1256. DMF5E6U RU https://www.ncbi.nlm.nih.gov/pubmed/27568917 DMXLJH4 DI DMXLJH4 DMXLJH4 DN Tricyclic heterocycle derivative 1 DMXLJH4 MI TT6DM01 DMXLJH4 MN Janus kinase 1 (JAK-1) DMXLJH4 MT DTT DMXLJH4 MA Inhibitor DMXLJH4 RN Inhibitors of JAK-family kinases: an update on the patent literature 2013-2015, part 2.Expert Opin Ther Pat. 2017 Feb;27(2):145-161. DMXLJH4 RU https://www.ncbi.nlm.nih.gov/pubmed/27774822 DMXLJH4 DI DMXLJH4 DMXLJH4 DN Tricyclic heterocycle derivative 1 DMXLJH4 MI TTRMX3V DMXLJH4 MN Janus kinase 2 (JAK-2) DMXLJH4 MT DTT DMXLJH4 MA Inhibitor DMXLJH4 RN Inhibitors of JAK-family kinases: an update on the patent literature 2013-2015, part 2.Expert Opin Ther Pat. 2017 Feb;27(2):145-161. DMXLJH4 RU https://www.ncbi.nlm.nih.gov/pubmed/27774822 DMXLJH4 DI DMXLJH4 DMXLJH4 DN Tricyclic heterocycle derivative 1 DMXLJH4 MI TTT7PJU DMXLJH4 MN Janus kinase 3 (JAK-3) DMXLJH4 MT DTT DMXLJH4 MA Inhibitor DMXLJH4 RN Inhibitors of JAK-family kinases: an update on the patent literature 2013-2015, part 2.Expert Opin Ther Pat. 2017 Feb;27(2):145-161. DMXLJH4 RU https://www.ncbi.nlm.nih.gov/pubmed/27774822 DMXLJH4 DI DMXLJH4 DMXLJH4 DN Tricyclic heterocycle derivative 1 DMXLJH4 MI TTBYWP2 DMXLJH4 MN TYK2 tyrosine kinase (TYK2) DMXLJH4 MT DTT DMXLJH4 MA Inhibitor DMXLJH4 RN Inhibitors of JAK-family kinases: an update on the patent literature 2013-2015, part 2.Expert Opin Ther Pat. 2017 Feb;27(2):145-161. DMXLJH4 RU https://www.ncbi.nlm.nih.gov/pubmed/27774822 DM1W02D DI DM1W02D DM1W02D DN Tricyclic heterocycle derivative 2 DM1W02D MI TTRMX3V DM1W02D MN Janus kinase 2 (JAK-2) DM1W02D MT DTT DM1W02D MA Inhibitor DM1W02D RN Inhibitors of JAK-family kinases: an update on the patent literature 2013-2015, part 1.Expert Opin Ther Pat. 2017 Feb;27(2):127-143. DM1W02D RU https://www.ncbi.nlm.nih.gov/pubmed/27774824 DM1W02D DI DM1W02D DM1W02D DN Tricyclic heterocycle derivative 2 DM1W02D MI TTT7PJU DM1W02D MN Janus kinase 3 (JAK-3) DM1W02D MT DTT DM1W02D MA Inhibitor DM1W02D RN Inhibitors of JAK-family kinases: an update on the patent literature 2013-2015, part 1.Expert Opin Ther Pat. 2017 Feb;27(2):127-143. DM1W02D RU https://www.ncbi.nlm.nih.gov/pubmed/27774824 DMJNCD6 DI DMJNCD6 DMJNCD6 DN Tricyclic heterocycle derivative 3 DMJNCD6 MI TTZC0KV DMJNCD6 MN Zinc finger-containing ubiquitin peptidase 1 (ZUP1) DMJNCD6 MT DTT DMJNCD6 MA Inhibitor DMJNCD6 RN Deubiquitinases (DUBs) and DUB inhibitors: a patent review.Expert Opin Ther Pat. 2015;25(10):1191-1208. DMJNCD6 RU https://www.ncbi.nlm.nih.gov/pubmed/26077642 DM9XBL4 DI DM9XBL4 DM9XBL4 DN Tricyclic heterocycle derivative 4 DM9XBL4 MI TTVSYP9 DM9XBL4 MN Ubiquitin carboxyl-terminal hydrolase 14 (USP14) DM9XBL4 MT DTT DM9XBL4 MA Inhibitor DM9XBL4 RN Deubiquitinases (DUBs) and DUB inhibitors: a patent review.Expert Opin Ther Pat. 2015;25(10):1191-1208. DM9XBL4 RU https://www.ncbi.nlm.nih.gov/pubmed/26077642 DMG1ESV DI DMG1ESV DMG1ESV DN Tricyclic heterocycle derivative 5 DMG1ESV MI TT6DM01 DMG1ESV MN Janus kinase 1 (JAK-1) DMG1ESV MT DTT DMG1ESV MA Inhibitor DMG1ESV RN Inhibitors of JAK-family kinases: an update on the patent literature 2013-2015, part 2.Expert Opin Ther Pat. 2017 Feb;27(2):145-161. DMG1ESV RU https://www.ncbi.nlm.nih.gov/pubmed/27774822 DMG1ESV DI DMG1ESV DMG1ESV DN Tricyclic heterocycle derivative 5 DMG1ESV MI TTRMX3V DMG1ESV MN Janus kinase 2 (JAK-2) DMG1ESV MT DTT DMG1ESV MA Inhibitor DMG1ESV RN Inhibitors of JAK-family kinases: an update on the patent literature 2013-2015, part 2.Expert Opin Ther Pat. 2017 Feb;27(2):145-161. DMG1ESV RU https://www.ncbi.nlm.nih.gov/pubmed/27774822 DMG1ESV DI DMG1ESV DMG1ESV DN Tricyclic heterocycle derivative 5 DMG1ESV MI TTT7PJU DMG1ESV MN Janus kinase 3 (JAK-3) DMG1ESV MT DTT DMG1ESV MA Inhibitor DMG1ESV RN Inhibitors of JAK-family kinases: an update on the patent literature 2013-2015, part 2.Expert Opin Ther Pat. 2017 Feb;27(2):145-161. DMG1ESV RU https://www.ncbi.nlm.nih.gov/pubmed/27774822 DMG1ESV DI DMG1ESV DMG1ESV DN Tricyclic heterocycle derivative 5 DMG1ESV MI TTBYWP2 DMG1ESV MN TYK2 tyrosine kinase (TYK2) DMG1ESV MT DTT DMG1ESV MA Inhibitor DMG1ESV RN Inhibitors of JAK-family kinases: an update on the patent literature 2013-2015, part 2.Expert Opin Ther Pat. 2017 Feb;27(2):145-161. DMG1ESV RU https://www.ncbi.nlm.nih.gov/pubmed/27774822 DMQJK70 DI DMQJK70 DMQJK70 DN Tricyclic heterocycle derivative 6 DMQJK70 MI TTDIGC1 DMQJK70 MN Dipeptidyl peptidase 4 (DPP-4) DMQJK70 MT DTT DMQJK70 MA Inhibitor DMQJK70 RN DPP-4 inhibitors: a patent review (2012 - 2014).Expert Opin Ther Pat. 2015 Feb;25(2):209-36. DMQJK70 RU https://www.ncbi.nlm.nih.gov/pubmed/25482888 DM4HBWU DI DM4HBWU DM4HBWU DN Tricyclic indole compound 1 DM4HBWU MI TTPTXIN DM4HBWU MN Translocator protein (TSPO) DM4HBWU MT DTT DM4HBWU MA Ligand DM4HBWU RN Translocator protein (TSPO) ligands for the diagnosis or treatment of neurodegenerative diseases: a patent review (2010 - 2015; part 2).Expert Opin Ther Pat. 2016 Nov;26(11):1353-1366. DM4HBWU RU https://www.ncbi.nlm.nih.gov/pubmed/27599163 DMK1QTH DI DMK1QTH DMK1QTH DN Tricyclic indole compound 10 DMK1QTH MI TTPTXIN DMK1QTH MN Translocator protein (TSPO) DMK1QTH MT DTT DMK1QTH MA Ligand DMK1QTH RN Translocator protein (TSPO) ligands for the diagnosis or treatment of neurodegenerative diseases: a patent review (2010 - 2015; part 2).Expert Opin Ther Pat. 2016 Nov;26(11):1353-1366. DMK1QTH RU https://www.ncbi.nlm.nih.gov/pubmed/27599163 DML724H DI DML724H DML724H DN Tricyclic indole compound 11 DML724H MI TTPTXIN DML724H MN Translocator protein (TSPO) DML724H MT DTT DML724H MA Ligand DML724H RN Translocator protein (TSPO) ligands for the diagnosis or treatment of neurodegenerative diseases: a patent review (2010 - 2015; part 2).Expert Opin Ther Pat. 2016 Nov;26(11):1353-1366. DML724H RU https://www.ncbi.nlm.nih.gov/pubmed/27599163 DMEZQ29 DI DMEZQ29 DMEZQ29 DN Tricyclic indole compound 12 DMEZQ29 MI TTPTXIN DMEZQ29 MN Translocator protein (TSPO) DMEZQ29 MT DTT DMEZQ29 MA Ligand DMEZQ29 RN Translocator protein (TSPO) ligands for the diagnosis or treatment of neurodegenerative diseases: a patent review (2010 - 2015; part 2).Expert Opin Ther Pat. 2016 Nov;26(11):1353-1366. DMEZQ29 RU https://www.ncbi.nlm.nih.gov/pubmed/27599163 DMS6XT4 DI DMS6XT4 DMS6XT4 DN Tricyclic indole compound 13 DMS6XT4 MI TTVDSZ0 DMS6XT4 MN Poly [ADP-ribose] polymerase 1 (PARP1) DMS6XT4 MT DTT DMS6XT4 MA Inhibitor DMS6XT4 RN PARP inhibitors as antitumor agents: a patent update (2013-2015).Expert Opin Ther Pat. 2017 Mar;27(3):363-382. DMS6XT4 RU https://www.ncbi.nlm.nih.gov/pubmed/27841036 DMXVNSR DI DMXVNSR DMXVNSR DN Tricyclic indole compound 14 DMXVNSR MI TTPTXIN DMXVNSR MN Translocator protein (TSPO) DMXVNSR MT DTT DMXVNSR MA Ligand DMXVNSR RN Translocator protein (TSPO) ligands for the diagnosis or treatment of neurodegenerative diseases: a patent review (2010 - 2015; part 2).Expert Opin Ther Pat. 2016 Nov;26(11):1353-1366. DMXVNSR RU https://www.ncbi.nlm.nih.gov/pubmed/27599163 DMHRY63 DI DMHRY63 DMHRY63 DN Tricyclic indole compound 2 DMHRY63 MI TTPTXIN DMHRY63 MN Translocator protein (TSPO) DMHRY63 MT DTT DMHRY63 MA Ligand DMHRY63 RN Translocator protein (TSPO) ligands for the diagnosis or treatment of neurodegenerative diseases: a patent review (2010 - 2015; part 2).Expert Opin Ther Pat. 2016 Nov;26(11):1353-1366. DMHRY63 RU https://www.ncbi.nlm.nih.gov/pubmed/27599163 DM5B92W DI DM5B92W DM5B92W DN Tricyclic indole compound 3 DM5B92W MI TTPTXIN DM5B92W MN Translocator protein (TSPO) DM5B92W MT DTT DM5B92W MA Ligand DM5B92W RN Translocator protein (TSPO) ligands for the diagnosis or treatment of neurodegenerative diseases: a patent review (2010 - 2015; part 2).Expert Opin Ther Pat. 2016 Nov;26(11):1353-1366. DM5B92W RU https://www.ncbi.nlm.nih.gov/pubmed/27599163 DMUZ4L3 DI DMUZ4L3 DMUZ4L3 DN Tricyclic indole compound 4 DMUZ4L3 MI TTPTXIN DMUZ4L3 MN Translocator protein (TSPO) DMUZ4L3 MT DTT DMUZ4L3 MA Ligand DMUZ4L3 RN Translocator protein (TSPO) ligands for the diagnosis or treatment of neurodegenerative diseases: a patent review (2010 - 2015; part 2).Expert Opin Ther Pat. 2016 Nov;26(11):1353-1366. DMUZ4L3 RU https://www.ncbi.nlm.nih.gov/pubmed/27599163 DMX5YG9 DI DMX5YG9 DMX5YG9 DN Tricyclic indole compound 5 DMX5YG9 MI TTPTXIN DMX5YG9 MN Translocator protein (TSPO) DMX5YG9 MT DTT DMX5YG9 MA Ligand DMX5YG9 RN Translocator protein (TSPO) ligands for the diagnosis or treatment of neurodegenerative diseases: a patent review (2010 - 2015; part 2).Expert Opin Ther Pat. 2016 Nov;26(11):1353-1366. DMX5YG9 RU https://www.ncbi.nlm.nih.gov/pubmed/27599163 DMXAS8P DI DMXAS8P DMXAS8P DN Tricyclic indole compound 6 DMXAS8P MI TTPTXIN DMXAS8P MN Translocator protein (TSPO) DMXAS8P MT DTT DMXAS8P MA Ligand DMXAS8P RN Translocator protein (TSPO) ligands for the diagnosis or treatment of neurodegenerative diseases: a patent review (2010 - 2015; part 2).Expert Opin Ther Pat. 2016 Nov;26(11):1353-1366. DMXAS8P RU https://www.ncbi.nlm.nih.gov/pubmed/27599163 DMFQSU8 DI DMFQSU8 DMFQSU8 DN Tricyclic indole compound 7 DMFQSU8 MI TTPTXIN DMFQSU8 MN Translocator protein (TSPO) DMFQSU8 MT DTT DMFQSU8 MA Ligand DMFQSU8 RN Translocator protein (TSPO) ligands for the diagnosis or treatment of neurodegenerative diseases: a patent review (2010 - 2015; part 2).Expert Opin Ther Pat. 2016 Nov;26(11):1353-1366. DMFQSU8 RU https://www.ncbi.nlm.nih.gov/pubmed/27599163 DMYAUVM DI DMYAUVM DMYAUVM DN Tricyclic indole compound 8 DMYAUVM MI TTPTXIN DMYAUVM MN Translocator protein (TSPO) DMYAUVM MT DTT DMYAUVM MA Ligand DMYAUVM RN Translocator protein (TSPO) ligands for the diagnosis or treatment of neurodegenerative diseases: a patent review (2010 - 2015; part 2).Expert Opin Ther Pat. 2016 Nov;26(11):1353-1366. DMYAUVM RU https://www.ncbi.nlm.nih.gov/pubmed/27599163 DMVA7BC DI DMVA7BC DMVA7BC DN Tricyclic indole compound 9 DMVA7BC MI TTPTXIN DMVA7BC MN Translocator protein (TSPO) DMVA7BC MT DTT DMVA7BC MA Ligand DMVA7BC RN Translocator protein (TSPO) ligands for the diagnosis or treatment of neurodegenerative diseases: a patent review (2010 - 2015; part 2).Expert Opin Ther Pat. 2016 Nov;26(11):1353-1366. DMVA7BC RU https://www.ncbi.nlm.nih.gov/pubmed/27599163 DM6QSND DI DM6QSND DM6QSND DN Tricyclic isoxazoloquinazoline derivative 1 DM6QSND MI TT5OU0D DM6QSND MN PRKR-like endoplasmic reticulum kinase (PERK) DM6QSND MT DTT DM6QSND MA Inhibitor DM6QSND RN Protein kinase R(PKR)-like endoplasmic reticulum kinase (PERK) inhibitors: a patent review (2010-2015).Expert Opin Ther Pat. 2017 Jan;27(1):37-48. DM6QSND RU https://www.ncbi.nlm.nih.gov/pubmed/27646439 DMH4TY1 DI DMH4TY1 DMH4TY1 DN Tricyclic isoxazoloquinazoline derivative 2 DMH4TY1 MI TTP7EGM DMH4TY1 MN Dual specificity protein kinase TTK (MPS1) DMH4TY1 MT DTT DMH4TY1 MA Inhibitor DMH4TY1 RN Protein kinase R(PKR)-like endoplasmic reticulum kinase (PERK) inhibitors: a patent review (2010-2015).Expert Opin Ther Pat. 2017 Jan;27(1):37-48. DMH4TY1 RU https://www.ncbi.nlm.nih.gov/pubmed/27646439 DMH4TY1 DI DMH4TY1 DMH4TY1 DN Tricyclic isoxazoloquinazoline derivative 2 DMH4TY1 MI TT5OU0D DMH4TY1 MN PRKR-like endoplasmic reticulum kinase (PERK) DMH4TY1 MT DTT DMH4TY1 MA Inhibitor DMH4TY1 RN Protein kinase R(PKR)-like endoplasmic reticulum kinase (PERK) inhibitors: a patent review (2010-2015).Expert Opin Ther Pat. 2017 Jan;27(1):37-48. DMH4TY1 RU https://www.ncbi.nlm.nih.gov/pubmed/27646439 DML2PWF DI DML2PWF DML2PWF DN Tricyclic isoxazoloquinazoline derivative 3 DML2PWF MI TTP7EGM DML2PWF MN Dual specificity protein kinase TTK (MPS1) DML2PWF MT DTT DML2PWF MA Inhibitor DML2PWF RN Protein kinase R(PKR)-like endoplasmic reticulum kinase (PERK) inhibitors: a patent review (2010-2015).Expert Opin Ther Pat. 2017 Jan;27(1):37-48. DML2PWF RU https://www.ncbi.nlm.nih.gov/pubmed/27646439 DML2PWF DI DML2PWF DML2PWF DN Tricyclic isoxazoloquinazoline derivative 3 DML2PWF MI TT5OU0D DML2PWF MN PRKR-like endoplasmic reticulum kinase (PERK) DML2PWF MT DTT DML2PWF MA Inhibitor DML2PWF RN Protein kinase R(PKR)-like endoplasmic reticulum kinase (PERK) inhibitors: a patent review (2010-2015).Expert Opin Ther Pat. 2017 Jan;27(1):37-48. DML2PWF RU https://www.ncbi.nlm.nih.gov/pubmed/27646439 DM8VIM4 DI DM8VIM4 DM8VIM4 DN Tricyclic isoxazoloquinazoline derivative 4 DM8VIM4 MI TTP7EGM DM8VIM4 MN Dual specificity protein kinase TTK (MPS1) DM8VIM4 MT DTT DM8VIM4 MA Inhibitor DM8VIM4 RN Protein kinase R(PKR)-like endoplasmic reticulum kinase (PERK) inhibitors: a patent review (2010-2015).Expert Opin Ther Pat. 2017 Jan;27(1):37-48. DM8VIM4 RU https://www.ncbi.nlm.nih.gov/pubmed/27646439 DM8VIM4 DI DM8VIM4 DM8VIM4 DN Tricyclic isoxazoloquinazoline derivative 4 DM8VIM4 MI TT5OU0D DM8VIM4 MN PRKR-like endoplasmic reticulum kinase (PERK) DM8VIM4 MT DTT DM8VIM4 MA Inhibitor DM8VIM4 RN Protein kinase R(PKR)-like endoplasmic reticulum kinase (PERK) inhibitors: a patent review (2010-2015).Expert Opin Ther Pat. 2017 Jan;27(1):37-48. DM8VIM4 RU https://www.ncbi.nlm.nih.gov/pubmed/27646439 DM94NZF DI DM94NZF DM94NZF DN Tricyclic phytocannabinoid derivative 1 DM94NZF MI TT6OEDT DM94NZF MN Cannabinoid receptor 1 (CB1) DM94NZF MT DTT DM94NZF RN Cannabinoid receptor 2 (CB2) agonists and antagonists: a patent update.Expert Opin Ther Pat. 2016 Jul;26(7):843-56. DM94NZF RU https://www.ncbi.nlm.nih.gov/pubmed/27215781 DM94NZF DI DM94NZF DM94NZF DN Tricyclic phytocannabinoid derivative 1 DM94NZF MI TTMSFAW DM94NZF MN Cannabinoid receptor 2 (CB2) DM94NZF MT DTT DM94NZF RN Cannabinoid receptor 2 (CB2) agonists and antagonists: a patent update.Expert Opin Ther Pat. 2016 Jul;26(7):843-56. DM94NZF RU https://www.ncbi.nlm.nih.gov/pubmed/27215781 DM7YVQL DI DM7YVQL DM7YVQL DN Tricyclic phytocannabinoid derivative 2 DM7YVQL MI TT6OEDT DM7YVQL MN Cannabinoid receptor 1 (CB1) DM7YVQL MT DTT DM7YVQL RN Cannabinoid receptor 2 (CB2) agonists and antagonists: a patent update.Expert Opin Ther Pat. 2016 Jul;26(7):843-56. DM7YVQL RU https://www.ncbi.nlm.nih.gov/pubmed/27215781 DM7YVQL DI DM7YVQL DM7YVQL DN Tricyclic phytocannabinoid derivative 2 DM7YVQL MI TTMSFAW DM7YVQL MN Cannabinoid receptor 2 (CB2) DM7YVQL MT DTT DM7YVQL RN Cannabinoid receptor 2 (CB2) agonists and antagonists: a patent update.Expert Opin Ther Pat. 2016 Jul;26(7):843-56. DM7YVQL RU https://www.ncbi.nlm.nih.gov/pubmed/27215781 DMGY3OR DI DMGY3OR DMGY3OR DN Tricyclic pyrrolidine derivative 1 DMGY3OR MI TTWJBZ5 DMGY3OR MN 5-HT 2C receptor (HTR2C) DMGY3OR MT DTT DMGY3OR MA Agonist DMGY3OR RN Novel serotonin receptor 2 (5-HT2R) agonists and antagonists: a patent review (2004-2014).Expert Opin Ther Pat. 2016;26(1):89-106. DMGY3OR RU https://www.ncbi.nlm.nih.gov/pubmed/26609882 DMRD1XJ DI DMRD1XJ DMRD1XJ DN Tricyclic pyrrolidine derivative 2 DMRD1XJ MI TTWJBZ5 DMRD1XJ MN 5-HT 2C receptor (HTR2C) DMRD1XJ MT DTT DMRD1XJ MA Agonist DMRD1XJ RN Novel serotonin receptor 2 (5-HT2R) agonists and antagonists: a patent review (2004-2014).Expert Opin Ther Pat. 2016;26(1):89-106. DMRD1XJ RU https://www.ncbi.nlm.nih.gov/pubmed/26609882 DMK2V6H DI DMK2V6H DMK2V6H DN Tricyclic pyrrolidine derivative 3 DMK2V6H MI TTWJBZ5 DMK2V6H MN 5-HT 2C receptor (HTR2C) DMK2V6H MT DTT DMK2V6H MA Agonist DMK2V6H RN Novel serotonin receptor 2 (5-HT2R) agonists and antagonists: a patent review (2004-2014).Expert Opin Ther Pat. 2016;26(1):89-106. DMK2V6H RU https://www.ncbi.nlm.nih.gov/pubmed/26609882 DM0JYWT DI DM0JYWT DM0JYWT DN Tricyclic pyrrolidine derivative 4 DM0JYWT MI TTWJBZ5 DM0JYWT MN 5-HT 2C receptor (HTR2C) DM0JYWT MT DTT DM0JYWT MA Agonist DM0JYWT RN Novel serotonin receptor 2 (5-HT2R) agonists and antagonists: a patent review (2004-2014).Expert Opin Ther Pat. 2016;26(1):89-106. DM0JYWT RU https://www.ncbi.nlm.nih.gov/pubmed/26609882 DMFIXW4 DI DMFIXW4 DMFIXW4 DN Tricyclic pyrrolopyridine compound 1 DMFIXW4 MI TT6DM01 DMFIXW4 MN Janus kinase 1 (JAK-1) DMFIXW4 MT DTT DMFIXW4 MA Inhibitor DMFIXW4 RN Inhibitors of JAK-family kinases: an update on the patent literature 2013-2015, part 2.Expert Opin Ther Pat. 2017 Feb;27(2):145-161. DMFIXW4 RU https://www.ncbi.nlm.nih.gov/pubmed/27774822 DMFIXW4 DI DMFIXW4 DMFIXW4 DN Tricyclic pyrrolopyridine compound 1 DMFIXW4 MI TTRMX3V DMFIXW4 MN Janus kinase 2 (JAK-2) DMFIXW4 MT DTT DMFIXW4 MA Inhibitor DMFIXW4 RN Inhibitors of JAK-family kinases: an update on the patent literature 2013-2015, part 2.Expert Opin Ther Pat. 2017 Feb;27(2):145-161. DMFIXW4 RU https://www.ncbi.nlm.nih.gov/pubmed/27774822 DMFIXW4 DI DMFIXW4 DMFIXW4 DN Tricyclic pyrrolopyridine compound 1 DMFIXW4 MI TTT7PJU DMFIXW4 MN Janus kinase 3 (JAK-3) DMFIXW4 MT DTT DMFIXW4 MA Inhibitor DMFIXW4 RN Inhibitors of JAK-family kinases: an update on the patent literature 2013-2015, part 2.Expert Opin Ther Pat. 2017 Feb;27(2):145-161. DMFIXW4 RU https://www.ncbi.nlm.nih.gov/pubmed/27774822 DMFIXW4 DI DMFIXW4 DMFIXW4 DN Tricyclic pyrrolopyridine compound 1 DMFIXW4 MI TTBYWP2 DMFIXW4 MN TYK2 tyrosine kinase (TYK2) DMFIXW4 MT DTT DMFIXW4 MA Inhibitor DMFIXW4 RN Inhibitors of JAK-family kinases: an update on the patent literature 2013-2015, part 2.Expert Opin Ther Pat. 2017 Feb;27(2):145-161. DMFIXW4 RU https://www.ncbi.nlm.nih.gov/pubmed/27774822 DMZTPUA DI DMZTPUA DMZTPUA DN Triptolidenol analog 1 DMZTPUA MI TTUX68I DMZTPUA MN Hypoxia-inducible factor 1 (HIF-1) DMZTPUA MT DTT DMZTPUA MA Inhibitor DMZTPUA RN Hypoxia-inducible factor (HIF) inhibitors: a patent survey (2011-2015).Expert Opin Ther Pat. 2016;26(3):309-22. DMZTPUA RU https://www.ncbi.nlm.nih.gov/pubmed/26882240 DMEQ3RD DI DMEQ3RD DMEQ3RD DN Tri-substituted benzene derivative 1 DMEQ3RD MI TTN9T81 DMEQ3RD MN Arachidonate 15-lipoxygenase (15-LOX) DMEQ3RD MT DTT DMEQ3RD MA Inhibitor DMEQ3RD RN 15-Lipoxygenase inhibitors: a patent review.Expert Opin Ther Pat. 2016;26(1):65-88. DMEQ3RD RU https://www.ncbi.nlm.nih.gov/pubmed/26560362 DM7NTO9 DI DM7NTO9 DM7NTO9 DN Tri-substituted purine derivative 1 DM7NTO9 MI TTH8FZW DM7NTO9 MN Signal transducer and activator of transcription 3 (STAT3) DM7NTO9 MT DTT DM7NTO9 MA Inhibitor DM7NTO9 RN A STAT inhibitor patent review: progress since 2011.Expert Opin Ther Pat. 2015;25(12):1397-421. DM7NTO9 RU https://www.ncbi.nlm.nih.gov/pubmed/26394986 DMHGRTX DI DMHGRTX DMHGRTX DN Tri-substituted urea derivative 1 DMHGRTX MI TTTDVOJ DMHGRTX MN Tropomyosin-related kinase A (TrkA) DMHGRTX MT DTT DMHGRTX MA Inhibitor DMHGRTX RN Tropomyosin receptor kinase inhibitors: an updated patent review for 2010-2016 - Part II.Expert Opin Ther Pat. 2017 Jul;27(7):831-849. DMHGRTX RU https://www.ncbi.nlm.nih.gov/pubmed/28270021 DMUVPR8 DI DMUVPR8 DMUVPR8 DN Tri-substituted urea derivative 2 DMUVPR8 MI TTTDVOJ DMUVPR8 MN Tropomyosin-related kinase A (TrkA) DMUVPR8 MT DTT DMUVPR8 MA Inhibitor DMUVPR8 RN Tropomyosin receptor kinase inhibitors: an updated patent review for 2010-2016 - Part II.Expert Opin Ther Pat. 2017 Jul;27(7):831-849. DMUVPR8 RU https://www.ncbi.nlm.nih.gov/pubmed/28270021 DMLJ2HE DI DMLJ2HE DMLJ2HE DN Undecylenic acid derivative 1 DMLJ2HE MI TT1WBIJ DMLJ2HE MN Calpain-1 (CAPN1) DMLJ2HE MT DTT DMLJ2HE RN An updated patent review of calpain inhibitors (2012 - 2014).Expert Opin Ther Pat. 2015 Jan;25(1):17-31. DMLJ2HE RU https://www.ncbi.nlm.nih.gov/pubmed/25399719 DMUD7H8 DI DMUD7H8 DMUD7H8 DN Unii-I92MU0V408 DMUD7H8 MI TT42OGM DMUD7H8 MN Hematopoietic cell kinase (HCK) DMUD7H8 MT DTT DMUD7H8 MA Inhibitor DMUD7H8 RN Respiratory formulations and compounds for use therein. US8933228. DMUD7H8 RU http://www.freepatentsonline.com/US8933228.html DMUHSAZ DI DMUHSAZ DMUHSAZ DN Unii-R228S06soh DMUHSAZ MI TTVSMOH DMUHSAZ MN Sphingosine-1-phosphate receptor 2 (S1PR2) DMUHSAZ MT DTT DMUHSAZ MA Inhibitor DMUHSAZ RN Sphingosine 1-phosphate receptor antagonists. US9663511. DMUHSAZ RU http://www.freepatentsonline.com/US9663511.html DM5SX8T DI DM5SX8T DM5SX8T DN Uracil derivative 1 DM5SX8T MI TTPLTSQ DM5SX8T MN Neutrophil elastase (NE) DM5SX8T MT DTT DM5SX8T MA Inhibitor DM5SX8T RN Neutrophil elastase inhibitors: a patent review and potential applications for inflammatory lung diseases (2010 - 2014).Expert Opin Ther Pat. 2015;25(10):1145-58. DM5SX8T RU https://www.ncbi.nlm.nih.gov/pubmed/26118988 DMEQFXZ DI DMEQFXZ DMEQFXZ DN Urea and carbamate bioisostere derivative 1 DMEQFXZ MI TTTB4UP DMEQFXZ MN Inosine-5'-monophosphate dehydrogenase 2 (IMPDH2) DMEQFXZ MT DTT DMEQFXZ MA Inhibitor DMEQFXZ RN Inosine-5'-monophosphate dehydrogenase (IMPDH) inhibitors: a patent and scientific literature review (2002-2016).Expert Opin Ther Pat. 2017 Jun;27(6):677-690. DMEQFXZ RU https://www.ncbi.nlm.nih.gov/pubmed/28074661 DMWNR8I DI DMWNR8I DMWNR8I DN Urea and carbamate bioisostere derivative 10 DMWNR8I MI TTL7C8Q DMWNR8I MN Inosine-5'-monophosphate dehydrogenase 1 (IMPDH1) DMWNR8I MT DTT DMWNR8I MA Inhibitor DMWNR8I RN Inosine-5'-monophosphate dehydrogenase (IMPDH) inhibitors: a patent and scientific literature review (2002-2016).Expert Opin Ther Pat. 2017 Jun;27(6):677-690. DMWNR8I RU https://www.ncbi.nlm.nih.gov/pubmed/28074661 DMAP6YS DI DMAP6YS DMAP6YS DN Urea and carbamate bioisostere derivative 11 DMAP6YS MI TTL7C8Q DMAP6YS MN Inosine-5'-monophosphate dehydrogenase 1 (IMPDH1) DMAP6YS MT DTT DMAP6YS MA Inhibitor DMAP6YS RN Inosine-5'-monophosphate dehydrogenase (IMPDH) inhibitors: a patent and scientific literature review (2002-2016).Expert Opin Ther Pat. 2017 Jun;27(6):677-690. DMAP6YS RU https://www.ncbi.nlm.nih.gov/pubmed/28074661 DM6BJEW DI DM6BJEW DM6BJEW DN Urea and carbamate bioisostere derivative 13 DM6BJEW MI TTL7C8Q DM6BJEW MN Inosine-5'-monophosphate dehydrogenase 1 (IMPDH1) DM6BJEW MT DTT DM6BJEW MA Inhibitor DM6BJEW RN Inosine-5'-monophosphate dehydrogenase (IMPDH) inhibitors: a patent and scientific literature review (2002-2016).Expert Opin Ther Pat. 2017 Jun;27(6):677-690. DM6BJEW RU https://www.ncbi.nlm.nih.gov/pubmed/28074661 DMDP09N DI DMDP09N DMDP09N DN Urea and carbamate bioisostere derivative 14 DMDP09N MI TTL7C8Q DMDP09N MN Inosine-5'-monophosphate dehydrogenase 1 (IMPDH1) DMDP09N MT DTT DMDP09N MA Inhibitor DMDP09N RN Inosine-5'-monophosphate dehydrogenase (IMPDH) inhibitors: a patent and scientific literature review (2002-2016).Expert Opin Ther Pat. 2017 Jun;27(6):677-690. DMDP09N RU https://www.ncbi.nlm.nih.gov/pubmed/28074661 DM3SQUD DI DM3SQUD DM3SQUD DN Urea and carbamate bioisostere derivative 15 DM3SQUD MI TTL7C8Q DM3SQUD MN Inosine-5'-monophosphate dehydrogenase 1 (IMPDH1) DM3SQUD MT DTT DM3SQUD MA Inhibitor DM3SQUD RN Inosine-5'-monophosphate dehydrogenase (IMPDH) inhibitors: a patent and scientific literature review (2002-2016).Expert Opin Ther Pat. 2017 Jun;27(6):677-690. DM3SQUD RU https://www.ncbi.nlm.nih.gov/pubmed/28074661 DMRLC4X DI DMRLC4X DMRLC4X DN Urea and carbamate bioisostere derivative 16 DMRLC4X MI TTL7C8Q DMRLC4X MN Inosine-5'-monophosphate dehydrogenase 1 (IMPDH1) DMRLC4X MT DTT DMRLC4X MA Inhibitor DMRLC4X RN Inosine-5'-monophosphate dehydrogenase (IMPDH) inhibitors: a patent and scientific literature review (2002-2016).Expert Opin Ther Pat. 2017 Jun;27(6):677-690. DMRLC4X RU https://www.ncbi.nlm.nih.gov/pubmed/28074661 DM7PSB1 DI DM7PSB1 DM7PSB1 DN Urea and carbamate bioisostere derivative 18 DM7PSB1 MI TTL7C8Q DM7PSB1 MN Inosine-5'-monophosphate dehydrogenase 1 (IMPDH1) DM7PSB1 MT DTT DM7PSB1 MA Inhibitor DM7PSB1 RN Inosine-5'-monophosphate dehydrogenase (IMPDH) inhibitors: a patent and scientific literature review (2002-2016).Expert Opin Ther Pat. 2017 Jun;27(6):677-690. DM7PSB1 RU https://www.ncbi.nlm.nih.gov/pubmed/28074661 DMRTJSC DI DMRTJSC DMRTJSC DN Urea and carbamate bioisostere derivative 2 DMRTJSC MI TTL7C8Q DMRTJSC MN Inosine-5'-monophosphate dehydrogenase 1 (IMPDH1) DMRTJSC MT DTT DMRTJSC MA Inhibitor DMRTJSC RN Inosine-5'-monophosphate dehydrogenase (IMPDH) inhibitors: a patent and scientific literature review (2002-2016).Expert Opin Ther Pat. 2017 Jun;27(6):677-690. DMRTJSC RU https://www.ncbi.nlm.nih.gov/pubmed/28074661 DMPXVWE DI DMPXVWE DMPXVWE DN Urea and carbamate bioisostere derivative 3 DMPXVWE MI TTL7C8Q DMPXVWE MN Inosine-5'-monophosphate dehydrogenase 1 (IMPDH1) DMPXVWE MT DTT DMPXVWE MA Inhibitor DMPXVWE RN Inosine-5'-monophosphate dehydrogenase (IMPDH) inhibitors: a patent and scientific literature review (2002-2016).Expert Opin Ther Pat. 2017 Jun;27(6):677-690. DMPXVWE RU https://www.ncbi.nlm.nih.gov/pubmed/28074661 DM5GZNS DI DM5GZNS DM5GZNS DN Urea and carbamate bioisostere derivative 4 DM5GZNS MI TTL7C8Q DM5GZNS MN Inosine-5'-monophosphate dehydrogenase 1 (IMPDH1) DM5GZNS MT DTT DM5GZNS MA Inhibitor DM5GZNS RN Inosine-5'-monophosphate dehydrogenase (IMPDH) inhibitors: a patent and scientific literature review (2002-2016).Expert Opin Ther Pat. 2017 Jun;27(6):677-690. DM5GZNS RU https://www.ncbi.nlm.nih.gov/pubmed/28074661 DM02ZM4 DI DM02ZM4 DM02ZM4 DN Urea and carbamate bioisostere derivative 5 DM02ZM4 MI TTL7C8Q DM02ZM4 MN Inosine-5'-monophosphate dehydrogenase 1 (IMPDH1) DM02ZM4 MT DTT DM02ZM4 MA Inhibitor DM02ZM4 RN Inosine-5'-monophosphate dehydrogenase (IMPDH) inhibitors: a patent and scientific literature review (2002-2016).Expert Opin Ther Pat. 2017 Jun;27(6):677-690. DM02ZM4 RU https://www.ncbi.nlm.nih.gov/pubmed/28074661 DMP29I0 DI DMP29I0 DMP29I0 DN Urea and carbamate bioisostere derivative 6 DMP29I0 MI TTL7C8Q DMP29I0 MN Inosine-5'-monophosphate dehydrogenase 1 (IMPDH1) DMP29I0 MT DTT DMP29I0 MA Inhibitor DMP29I0 RN Inosine-5'-monophosphate dehydrogenase (IMPDH) inhibitors: a patent and scientific literature review (2002-2016).Expert Opin Ther Pat. 2017 Jun;27(6):677-690. DMP29I0 RU https://www.ncbi.nlm.nih.gov/pubmed/28074661 DM2GPLQ DI DM2GPLQ DM2GPLQ DN Urea and carbamate bioisostere derivative 7 DM2GPLQ MI TTL7C8Q DM2GPLQ MN Inosine-5'-monophosphate dehydrogenase 1 (IMPDH1) DM2GPLQ MT DTT DM2GPLQ MA Inhibitor DM2GPLQ RN Inosine-5'-monophosphate dehydrogenase (IMPDH) inhibitors: a patent and scientific literature review (2002-2016).Expert Opin Ther Pat. 2017 Jun;27(6):677-690. DM2GPLQ RU https://www.ncbi.nlm.nih.gov/pubmed/28074661 DMIYD41 DI DMIYD41 DMIYD41 DN Urea and carbamate bioisostere derivative 9 DMIYD41 MI TTL7C8Q DMIYD41 MN Inosine-5'-monophosphate dehydrogenase 1 (IMPDH1) DMIYD41 MT DTT DMIYD41 MA Inhibitor DMIYD41 RN Inosine-5'-monophosphate dehydrogenase (IMPDH) inhibitors: a patent and scientific literature review (2002-2016).Expert Opin Ther Pat. 2017 Jun;27(6):677-690. DMIYD41 RU https://www.ncbi.nlm.nih.gov/pubmed/28074661 DMN51XF DI DMN51XF DMN51XF DN Ureido-phenyl-substituted triazine derivative 1 DMN51XF MI TTTDVOJ DMN51XF MN Tropomyosin-related kinase A (TrkA) DMN51XF MT DTT DMN51XF MA Inhibitor DMN51XF RN Tropomyosin receptor kinase inhibitors: an updated patent review for 2010-2016 - Part I.Expert Opin Ther Pat. 2017 Jun;27(6):733-751. DMN51XF RU https://www.ncbi.nlm.nih.gov/pubmed/28270010 DMR0JDW DI DMR0JDW DMR0JDW DN Ureido-phenyl-substituted triazine derivative 2 DMR0JDW MI TTTDVOJ DMR0JDW MN Tropomyosin-related kinase A (TrkA) DMR0JDW MT DTT DMR0JDW MA Inhibitor DMR0JDW RN Tropomyosin receptor kinase inhibitors: an updated patent review for 2010-2016 - Part I.Expert Opin Ther Pat. 2017 Jun;27(6):733-751. DMR0JDW RU https://www.ncbi.nlm.nih.gov/pubmed/28270010 DMVCWXD DI DMVCWXD DMVCWXD DN US10022354, Example 151 DMVCWXD MI TTIG67W DMVCWXD MN Lysine-specific demethylase 5A (KDM5A) DMVCWXD MT DTT DMVCWXD MA Inhibitor DMVCWXD RN IRE-1 inhibitors DMVCWXD RU http://www.freepatentsonline.com/US10022354.html DMGDZLP DI DMGDZLP DMGDZLP DN US10022354, Example 152 DMGDZLP MI TTIG67W DMGDZLP MN Lysine-specific demethylase 5A (KDM5A) DMGDZLP MT DTT DMGDZLP MA Inhibitor DMGDZLP RN IRE-1 inhibitors DMGDZLP RU http://www.freepatentsonline.com/US10022354.html DMIAGPX DI DMIAGPX DMIAGPX DN US10022354, Example 5 DMIAGPX MI TTIG67W DMIAGPX MN Lysine-specific demethylase 5A (KDM5A) DMIAGPX MT DTT DMIAGPX MA Inhibitor DMIAGPX RN IRE-1 inhibitors DMIAGPX RU http://www.freepatentsonline.com/US10022354.html DMU21PD DI DMU21PD DMU21PD DN US10023583, Example 13 DMU21PD MI TTY2KP7 DMU21PD MN Leucyl-cysteinyl aminopeptidase (LNPEP) DMU21PD MT DTT DMU21PD MA Inhibitor DMU21PD RN Bicyclic pyridine compound. US10023583. DMU21PD RU http://www.freepatentsonline.com/US10023583.html DM5LK6O DI DM5LK6O DM5LK6O DN US10023583, Example 24 DM5LK6O MI TTY2KP7 DM5LK6O MN Leucyl-cysteinyl aminopeptidase (LNPEP) DM5LK6O MT DTT DM5LK6O MA Inhibitor DM5LK6O RN Bicyclic pyridine compound. US10023583. DM5LK6O RU http://www.freepatentsonline.com/US10023583.html DMZR10T DI DMZR10T DMZR10T DN US10023583, Example 5 DMZR10T MI TTY2KP7 DMZR10T MN Leucyl-cysteinyl aminopeptidase (LNPEP) DMZR10T MT DTT DMZR10T MA Inhibitor DMZR10T RN Bicyclic pyridine compound. US10023583. DMZR10T RU http://www.freepatentsonline.com/US10023583.html DM40KU8 DI DM40KU8 DM40KU8 DN US10023583, Example 8 DM40KU8 MI TTY2KP7 DM40KU8 MN Leucyl-cysteinyl aminopeptidase (LNPEP) DM40KU8 MT DTT DM40KU8 MA Inhibitor DM40KU8 RN Bicyclic pyridine compound. US10023583. DM40KU8 RU http://www.freepatentsonline.com/US10023583.html DMG4T13 DI DMG4T13 DMG4T13 DN US10030004, Compound 11a DMG4T13 MI TTPKHTZ DMG4T13 MN Activin receptor type IB (ACVR1B) DMG4T13 MT DTT DMG4T13 MA Inhibitor DMG4T13 RN Compounds and methods of use. US10030004. DMG4T13 RU http://www.freepatentsonline.com/US10030004.html DM0RAPC DI DM0RAPC DM0RAPC DN US10030004, Compound 19 DM0RAPC MI TTPKHTZ DM0RAPC MN Activin receptor type IB (ACVR1B) DM0RAPC MT DTT DM0RAPC MA Inhibitor DM0RAPC RN Compounds and methods of use. US10030004. DM0RAPC RU http://www.freepatentsonline.com/US10030004.html DMD0GN6 DI DMD0GN6 DMD0GN6 DN US10030004, Compound 33 DMD0GN6 MI TTPKHTZ DMD0GN6 MN Activin receptor type IB (ACVR1B) DMD0GN6 MT DTT DMD0GN6 MA Inhibitor DMD0GN6 RN Compounds and methods of use. US10030004. DMD0GN6 RU http://www.freepatentsonline.com/US10030004.html DMLJV01 DI DMLJV01 DMLJV01 DN US10034861, Example 1 DMLJV01 MI TT3ZS42 DMLJV01 MN Phosphodiesterase 1B (PDE1B) DMLJV01 MT DTT DMLJV01 MA Inhibitor DMLJV01 RN 1H-pyrazolo[4,3-b]pyridines as PDE1 inhibitors. US10034861. DMLJV01 RU http://www.freepatentsonline.com/US10034861.html DM27SFD DI DM27SFD DM27SFD DN US10034861, Example 164 DM27SFD MI TT3ZS42 DM27SFD MN Phosphodiesterase 1B (PDE1B) DM27SFD MT DTT DM27SFD MA Inhibitor DM27SFD RN 1H-pyrazolo[4,3-b]pyridines as PDE1 inhibitors. US10034861. DM27SFD RU http://www.freepatentsonline.com/US10034861.html DMD8FS5 DI DMD8FS5 DMD8FS5 DN US10034861, Example 165 DMD8FS5 MI TT3ZS42 DMD8FS5 MN Phosphodiesterase 1B (PDE1B) DMD8FS5 MT DTT DMD8FS5 MA Inhibitor DMD8FS5 RN 1H-pyrazolo[4,3-b]pyridines as PDE1 inhibitors. US10034861. DMD8FS5 RU http://www.freepatentsonline.com/US10034861.html DM28XHN DI DM28XHN DM28XHN DN US10035778, Example 1 DM28XHN MI TTIF29E DM28XHN MN Integrin beta-8 (ITGB8) DM28XHN MT DTT DM28XHN MA Inhibitor DM28XHN RN Meta-azacyclic amino benzoic acid derivatives as pan integrin antagonists. US10035778. DM28XHN RU http://www.freepatentsonline.com/US10035778.html DMBN6W2 DI DMBN6W2 DMBN6W2 DN US10035778, Example 12 DMBN6W2 MI TTIF29E DMBN6W2 MN Integrin beta-8 (ITGB8) DMBN6W2 MT DTT DMBN6W2 MA Inhibitor DMBN6W2 RN Meta-azacyclic amino benzoic acid derivatives as pan integrin antagonists. US10035778. DMBN6W2 RU http://www.freepatentsonline.com/US10035778.html DMJ53DR DI DMJ53DR DMJ53DR DN US10035778, Example 16 DMJ53DR MI TTIF29E DMJ53DR MN Integrin beta-8 (ITGB8) DMJ53DR MT DTT DMJ53DR MA Inhibitor DMJ53DR RN Meta-azacyclic amino benzoic acid derivatives as pan integrin antagonists. US10035778. DMJ53DR RU http://www.freepatentsonline.com/US10035778.html DMLMV1Y DI DMLMV1Y DMLMV1Y DN US10040779, Example 1 DMLMV1Y MI TTIG67W DMLMV1Y MN Lysine-specific demethylase 5A (KDM5A) DMLMV1Y MT DTT DMLMV1Y MA Inhibitor DMLMV1Y RN Histone demethylase inhibitors. US10040779. DMLMV1Y RU http://www.freepatentsonline.com/US10040779.html DMWDGCH DI DMWDGCH DMWDGCH DN US10040779, Example 4 DMWDGCH MI TTIG67W DMWDGCH MN Lysine-specific demethylase 5A (KDM5A) DMWDGCH MT DTT DMWDGCH MA Inhibitor DMWDGCH RN Histone demethylase inhibitors. US10040779. DMWDGCH RU http://www.freepatentsonline.com/US10040779.html DMPM8VB DI DMPM8VB DMPM8VB DN US10053465, 12 DMPM8VB MI TTIEMFN DMPM8VB MN TYRO3 tyrosine kinase receptor (TYRO3) DMPM8VB MT DTT DMPM8VB MA Inhibitor DMPM8VB RN Fused bicyclic 1,2,4-triazine compounds as TAM inhibitors. US9708333. DMPM8VB RU http://www.freepatentsonline.com/US9708333.html DMV7BF2 DI DMV7BF2 DMV7BF2 DN US10053465, 5 DMV7BF2 MI TTIEMFN DMV7BF2 MN TYRO3 tyrosine kinase receptor (TYRO3) DMV7BF2 MT DTT DMV7BF2 MA Inhibitor DMV7BF2 RN Fused bicyclic 1,2,4-triazine compounds as TAM inhibitors. US9708333. DMV7BF2 RU http://www.freepatentsonline.com/US9708333.html DM42XWO DI DM42XWO DM42XWO DN US10053465, 8 DM42XWO MI TTIEMFN DM42XWO MN TYRO3 tyrosine kinase receptor (TYRO3) DM42XWO MT DTT DM42XWO MA Inhibitor DM42XWO RN Pyrrolopyrimidine derivatives as TAM inhibitors. US10053465. DM42XWO RU http://www.freepatentsonline.com/US10053465.html DMBD95S DI DMBD95S DMBD95S DN US10059720, Example 80 DMBD95S MI TTY2KP7 DMBD95S MN Leucyl-cysteinyl aminopeptidase (LNPEP) DMBD95S MT DTT DMBD95S MA Inhibitor DMBD95S RN Pyridine derivative. US10059720. DMBD95S RU http://www.freepatentsonline.com/US10059720.html DMJ6GU9 DI DMJ6GU9 DMJ6GU9 DN US10059720, Example 82 DMJ6GU9 MI TTY2KP7 DMJ6GU9 MN Leucyl-cysteinyl aminopeptidase (LNPEP) DMJ6GU9 MT DTT DMJ6GU9 MA Inhibitor DMJ6GU9 RN Pyridine derivative. US10059720. DMJ6GU9 RU http://www.freepatentsonline.com/US10059720.html DMKLVE4 DI DMKLVE4 DMKLVE4 DN US10059720, Example 84 DMKLVE4 MI TTY2KP7 DMKLVE4 MN Leucyl-cysteinyl aminopeptidase (LNPEP) DMKLVE4 MT DTT DMKLVE4 MA Inhibitor DMKLVE4 RN Pyridine derivative. US10059720. DMKLVE4 RU http://www.freepatentsonline.com/US10059720.html DMBWJK4 DI DMBWJK4 DMBWJK4 DN US10065972, Example 281 DMBWJK4 MI TTT3IXG DMBWJK4 MN Kynurenine oxoglutarate transaminase II (AADAT) DMBWJK4 MT DTT DMBWJK4 MA Inhibitor DMBWJK4 RN Bicyclic or tricyclic heterocyclic compound. US10065972. DMBWJK4 RU http://www.freepatentsonline.com/US10065972.html DMT8WVZ DI DMT8WVZ DMT8WVZ DN US10065972, Example 396 DMT8WVZ MI TTT3IXG DMT8WVZ MN Kynurenine oxoglutarate transaminase II (AADAT) DMT8WVZ MT DTT DMT8WVZ MA Inhibitor DMT8WVZ RN Bicyclic or tricyclic heterocyclic compound. US10065972. DMT8WVZ RU http://www.freepatentsonline.com/US10065972.html DM9QCTJ DI DM9QCTJ DM9QCTJ DN US10065972, Example 560 DM9QCTJ MI TTT3IXG DM9QCTJ MN Kynurenine oxoglutarate transaminase II (AADAT) DM9QCTJ MT DTT DM9QCTJ MA Inhibitor DM9QCTJ RN Bicyclic or tricyclic heterocyclic compound. US10065972. DM9QCTJ RU http://www.freepatentsonline.com/US10065972.html DM95YLX DI DM95YLX DM95YLX DN US10071110, Compound cCDV DM95YLX MI TT5DOVB DM95YLX MN Cytomegalovirus Protease (CMV UL80) DM95YLX MT DTT DM95YLX MA Inhibitor DM95YLX RN Phosphonate compounds. US10071110. DM95YLX RU http://www.freepatentsonline.com/US10071110.html DMOZ84C DI DMOZ84C DMOZ84C DN US10077269, Example 6 DMOZ84C MI TT6A59G DMOZ84C MN Phosphodiesterase 4C (PDE4C) DMOZ84C MT DTT DMOZ84C MA Inhibitor DMOZ84C RN Imidazopyridazine compounds. US9598421. DMOZ84C RU http://www.freepatentsonline.com/US9598421.html DM3BDHN DI DM3BDHN DM3BDHN DN US10081632, Compound 25 DM3BDHN MI TT3KYWB DM3BDHN MN Ribosomal protein S6 kinase alpha-6 (RSK6) DM3BDHN MT DTT DM3BDHN MA Inhibitor DM3BDHN RN Substituted tetrahydropyrido[3,2:4,5]pyrrolo[1,2-a]pyrazine-2-carboxamides as RSK inhibitors. US9771366. DM3BDHN RU http://www.freepatentsonline.com/US9771366.html DMM6WAB DI DMM6WAB DMM6WAB DN US10087167, Compound 3002 DMM6WAB MI TTQFZWR DMM6WAB MN Hepatitis C virus Core protein messenger RNA (HCV Core mRNA) DMM6WAB MT DTT DMM6WAB MA Inhibitor DMM6WAB RN Benzofurans substituted with secondary benzamide as HCV inhibitors. US10087167. DMM6WAB RU http://www.freepatentsonline.com/US10087167.html DMITOY6 DI DMITOY6 DMITOY6 DN US10087167, Compound 3003 DMITOY6 MI TTQFZWR DMITOY6 MN Hepatitis C virus Core protein messenger RNA (HCV Core mRNA) DMITOY6 MT DTT DMITOY6 MA Inhibitor DMITOY6 RN Benzofurans substituted with secondary benzamide as HCV inhibitors. US10087167. DMITOY6 RU http://www.freepatentsonline.com/US10087167.html DMAP1DN DI DMAP1DN DMAP1DN DN US10087167, Compound 4001 DMAP1DN MI TTQFZWR DMAP1DN MN Hepatitis C virus Core protein messenger RNA (HCV Core mRNA) DMAP1DN MT DTT DMAP1DN MA Inhibitor DMAP1DN RN Benzofurans substituted with secondary benzamide as HCV inhibitors. US10087167. DMAP1DN RU http://www.freepatentsonline.com/US10087167.html DMU8CAD DI DMU8CAD DMU8CAD DN US10092575, Example 101 DMU8CAD MI TT3ZS42 DMU8CAD MN Phosphodiesterase 1B (PDE1B) DMU8CAD MT DTT DMU8CAD MA Inhibitor DMU8CAD RN Substituted thiophene- and furan-fused azolopyrimidine-5-(6H)-one compounds. US10092575. DMU8CAD RU http://www.freepatentsonline.com/US10092575.html DMT47DF DI DMT47DF DMT47DF DN US10092575, Example 141 DMT47DF MI TT3ZS42 DMT47DF MN Phosphodiesterase 1B (PDE1B) DMT47DF MT DTT DMT47DF MA Inhibitor DMT47DF RN Therapeutic thiophene-, furan-, and pyridine-fused azolopyrimidin-5-(6h)-ones. US10105367. DMT47DF RU http://www.freepatentsonline.com/US10105367.html DM7MNE2 DI DM7MNE2 DM7MNE2 DN US10092575, Example 158 DM7MNE2 MI TT3ZS42 DM7MNE2 MN Phosphodiesterase 1B (PDE1B) DM7MNE2 MT DTT DM7MNE2 MA Inhibitor DM7MNE2 RN Substituted thiophene- and furan-fused azolopyrimidine-5-(6H)-one compounds. US10092575. DM7MNE2 RU http://www.freepatentsonline.com/US10092575.html DMJKS4X DI DMJKS4X DMJKS4X DN US10100051, Compound 1 DMJKS4X MI TT9ISBX DMJKS4X MN HIF-prolyl hydroxylase 2 (HPH-2) DMJKS4X MT DTT DMJKS4X MA Inhibitor DMJKS4X RN Compound of 5-hydroxyl-1,7-naphthyridine substituted by aryloxy or heteroaryloxy, preparation method thereof and pharmaceutical use thereof. US10100051. DMJKS4X RU http://www.freepatentsonline.com/US10100051.html DMQ7ODW DI DMQ7ODW DMQ7ODW DN US10100051, Compound 10 DMQ7ODW MI TT9ISBX DMQ7ODW MN HIF-prolyl hydroxylase 2 (HPH-2) DMQ7ODW MT DTT DMQ7ODW MA Inhibitor DMQ7ODW RN Compound of 5-hydroxyl-1,7-naphthyridine substituted by aryloxy or heteroaryloxy, preparation method thereof and pharmaceutical use thereof. US10100051. DMQ7ODW RU http://www.freepatentsonline.com/US10100051.html DM2DEOA DI DM2DEOA DM2DEOA DN US10100051, Compound 11 DM2DEOA MI TT9ISBX DM2DEOA MN HIF-prolyl hydroxylase 2 (HPH-2) DM2DEOA MT DTT DM2DEOA MA Inhibitor DM2DEOA RN Compound of 5-hydroxyl-1,7-naphthyridine substituted by aryloxy or heteroaryloxy, preparation method thereof and pharmaceutical use thereof. US10100051. DM2DEOA RU http://www.freepatentsonline.com/US10100051.html DMWESZ1 DI DMWESZ1 DMWESZ1 DN US10100051, Compound 2 DMWESZ1 MI TT9ISBX DMWESZ1 MN HIF-prolyl hydroxylase 2 (HPH-2) DMWESZ1 MT DTT DMWESZ1 MA Inhibitor DMWESZ1 RN Compound of 5-hydroxyl-1,7-naphthyridine substituted by aryloxy or heteroaryloxy, preparation method thereof and pharmaceutical use thereof. US10100051. DMWESZ1 RU http://www.freepatentsonline.com/US10100051.html DMEVGR6 DI DMEVGR6 DMEVGR6 DN US10149841, Compound 1 DMEVGR6 MI TT9ISBX DMEVGR6 MN HIF-prolyl hydroxylase 2 (HPH-2) DMEVGR6 MT DTT DMEVGR6 MA Inhibitor DMEVGR6 RN Compound of 3-hydroxyl pyridine, preparation method thereof and pharmaceutical use thereof. US10149841. DMEVGR6 RU http://www.freepatentsonline.com/US10149841.html DMYSI9J DI DMYSI9J DMYSI9J DN US10149841, Compound 19 DMYSI9J MI TT9ISBX DMYSI9J MN HIF-prolyl hydroxylase 2 (HPH-2) DMYSI9J MT DTT DMYSI9J MA Inhibitor DMYSI9J RN Compound of 3-hydroxyl pyridine, preparation method thereof and pharmaceutical use thereof. US10149841. DMYSI9J RU http://www.freepatentsonline.com/US10149841.html DMBS50K DI DMBS50K DMBS50K DN US10149841, Compound 5 DMBS50K MI TT9ISBX DMBS50K MN HIF-prolyl hydroxylase 2 (HPH-2) DMBS50K MT DTT DMBS50K MA Inhibitor DMBS50K RN Compound of 3-hydroxyl pyridine, preparation method thereof and pharmaceutical use thereof. US10149841. DMBS50K RU http://www.freepatentsonline.com/US10149841.html DMS415A DI DMS415A DMS415A DN US10149841, Compound 9 DMS415A MI TT9ISBX DMS415A MN HIF-prolyl hydroxylase 2 (HPH-2) DMS415A MT DTT DMS415A MA Inhibitor DMS415A RN Compound of 3-hydroxyl pyridine, preparation method thereof and pharmaceutical use thereof. US10149841. DMS415A RU http://www.freepatentsonline.com/US10149841.html DME2AZG DI DME2AZG DME2AZG DN US10150740, Example 1 DME2AZG MI TTQFZWR DME2AZG MN Hepatitis C virus Core protein messenger RNA (HCV Core mRNA) DME2AZG MT DTT DME2AZG MA Inhibitor DME2AZG RN 6,7-dihydropyrido[2,1-A]phthalazin-2-ones for the treatment and prophylaxis of hepatitis B virus infection. US10150740. DME2AZG RU http://www.freepatentsonline.com/US10150740.html DMKM93Q DI DMKM93Q DMKM93Q DN US10150740, Example 4 DMKM93Q MI TTQFZWR DMKM93Q MN Hepatitis C virus Core protein messenger RNA (HCV Core mRNA) DMKM93Q MT DTT DMKM93Q MA Inhibitor DMKM93Q RN 6,7-dihydropyrido[2,1-A]phthalazin-2-ones for the treatment and prophylaxis of hepatitis B virus infection. US10150740. DMKM93Q RU http://www.freepatentsonline.com/US10150740.html DM1VPLU DI DM1VPLU DM1VPLU DN US10150740, Example 9 DM1VPLU MI TTQFZWR DM1VPLU MN Hepatitis C virus Core protein messenger RNA (HCV Core mRNA) DM1VPLU MT DTT DM1VPLU MA Inhibitor DM1VPLU RN 6,7-dihydropyrido[2,1-A]phthalazin-2-ones for the treatment and prophylaxis of hepatitis B virus infection. US10150740. DM1VPLU RU http://www.freepatentsonline.com/US10150740.html DMVMNP1 DI DMVMNP1 DMVMNP1 DN US10166249, Example 695 DMVMNP1 MI TTDYP7I DMVMNP1 MN Sphingosine-1-phosphate receptor 3 (S1PR3) DMVMNP1 MT DTT DMVMNP1 MA Inhibitor DMVMNP1 RN Substituted bicyclic compounds. US10166249. DMVMNP1 RU http://www.freepatentsonline.com/US10166249.html DMSYRI3 DI DMSYRI3 DMSYRI3 DN US10174026, Example 2 DMSYRI3 MI TTIG67W DMSYRI3 MN Lysine-specific demethylase 5A (KDM5A) DMSYRI3 MT DTT DMSYRI3 MA Inhibitor DMSYRI3 RN Histone demethylase inhibitors. US10174026. DMSYRI3 RU http://www.freepatentsonline.com/US10174026.html DMJKTYW DI DMJKTYW DMJKTYW DN US10174026, Example 99 DMJKTYW MI TTIG67W DMJKTYW MN Lysine-specific demethylase 5A (KDM5A) DMJKTYW MT DTT DMJKTYW MA Inhibitor DMJKTYW RN Histone demethylase inhibitors. US10174026. DMJKTYW RU http://www.freepatentsonline.com/US10174026.html DMGTBO3 DI DMGTBO3 DMGTBO3 DN US10179791, Compound 171 DMGTBO3 MI TTDYP7I DMGTBO3 MN Sphingosine-1-phosphate receptor 3 (S1PR3) DMGTBO3 MT DTT DMGTBO3 MA Inhibitor DMGTBO3 RN Spiro-cyclic amine derivatives as S1P modulators. US10179791. DMGTBO3 RU http://www.freepatentsonline.com/US10179791.html DMRHQLF DI DMRHQLF DMRHQLF DN US10179791, Compound 176 DMRHQLF MI TTDYP7I DMRHQLF MN Sphingosine-1-phosphate receptor 3 (S1PR3) DMRHQLF MT DTT DMRHQLF MA Inhibitor DMRHQLF RN Spiro-cyclic amine derivatives as S1P modulators. US10179791. DMRHQLF RU http://www.freepatentsonline.com/US10179791.html DMLZBRM DI DMLZBRM DMLZBRM DN US10179791, Compound 296 DMLZBRM MI TTDYP7I DMLZBRM MN Sphingosine-1-phosphate receptor 3 (S1PR3) DMLZBRM MT DTT DMLZBRM MA Inhibitor DMLZBRM RN Spiro-cyclic amine derivatives as S1P modulators. US10179791. DMLZBRM RU http://www.freepatentsonline.com/US10179791.html DMAE6CK DI DMAE6CK DMAE6CK DN US20160326143, 28 DMAE6CK MI TTW7OTG DMAE6CK MN Leukotriene C4 synthase (LTC4S) DMAE6CK MT DTT DMAE6CK MA Inhibitor DMAE6CK RN COMPOUNDS AND USES. US20160326143. DMAE6CK RU http://www.freepatentsonline.com/US20160326143.html DML5KXB DI DML5KXB DML5KXB DN US20160326143, 3 DML5KXB MI TTW7OTG DML5KXB MN Leukotriene C4 synthase (LTC4S) DML5KXB MT DTT DML5KXB MA Inhibitor DML5KXB RN COMPOUNDS AND USES. US20160326143. DML5KXB RU http://www.freepatentsonline.com/US20160326143.html DMUDE89 DI DMUDE89 DMUDE89 DN US20160326143, 38 DMUDE89 MI TTW7OTG DMUDE89 MN Leukotriene C4 synthase (LTC4S) DMUDE89 MT DTT DMUDE89 MA Inhibitor DMUDE89 RN Compounds and uses. US9657001. DMUDE89 RU http://www.freepatentsonline.com/US9657001.html DM2DU7R DI DM2DU7R DM2DU7R DN US20160326143, 50 DM2DU7R MI TTW7OTG DM2DU7R MN Leukotriene C4 synthase (LTC4S) DM2DU7R MT DTT DM2DU7R MA Inhibitor DM2DU7R RN Compounds and uses. US9657001. DM2DU7R RU http://www.freepatentsonline.com/US9657001.html DMH7JVA DI DMH7JVA DMH7JVA DN US8470836, 2 DMH7JVA MI TTOYT5L DMH7JVA MN Dipeptidyl-peptidase 7 (DPP7) DMH7JVA MT DTT DMH7JVA MA Inhibitor DMH7JVA RN Dipeptidyl peptidase-IV inhibiting compounds, methods of preparing the same, and pharmaceutical compositions containing the same as active agent. US8470836. DMH7JVA RU http://www.freepatentsonline.com/US8470836.html DMYR10P DI DMYR10P DMYR10P DN US8470836, 5 DMYR10P MI TTOYT5L DMYR10P MN Dipeptidyl-peptidase 7 (DPP7) DMYR10P MT DTT DMYR10P MA Inhibitor DMYR10P RN Dipeptidyl peptidase-IV inhibiting compounds, methods of preparing the same, and pharmaceutical compositions containing the same as active agent. US8470836. DMYR10P RU http://www.freepatentsonline.com/US8470836.html DMVYQXH DI DMVYQXH DMVYQXH DN US8470836, 6 DMVYQXH MI TTOYT5L DMVYQXH MN Dipeptidyl-peptidase 7 (DPP7) DMVYQXH MT DTT DMVYQXH MA Inhibitor DMVYQXH RN Dipeptidyl peptidase-IV inhibiting compounds, methods of preparing the same, and pharmaceutical compositions containing the same as active agent. US8470836. DMVYQXH RU http://www.freepatentsonline.com/US8470836.html DMM4GLH DI DMM4GLH DMM4GLH DN US8470836, 8 DMM4GLH MI TTOYT5L DMM4GLH MN Dipeptidyl-peptidase 7 (DPP7) DMM4GLH MT DTT DMM4GLH MA Inhibitor DMM4GLH RN Dipeptidyl peptidase-IV inhibiting compounds, methods of preparing the same, and pharmaceutical compositions containing the same as active agent. US8470836. DMM4GLH RU http://www.freepatentsonline.com/US8470836.html DMFEUMZ DI DMFEUMZ DMFEUMZ DN US8481586, 15 DMFEUMZ MI TTCGOIN DMFEUMZ MN PIM-3 protein kinase (PIM3) DMFEUMZ MT DTT DMFEUMZ MA Inhibitor DMFEUMZ RN Pyrrolo[2,3-a] carbazoles and use thereof as PIM kinase inhibitors. US8481586. DMFEUMZ RU http://www.freepatentsonline.com/US8481586.html DM6U3ZR DI DM6U3ZR DM6U3ZR DN US8481586, 40 DM6U3ZR MI TTCGOIN DM6U3ZR MN PIM-3 protein kinase (PIM3) DM6U3ZR MT DTT DM6U3ZR MA Inhibitor DM6U3ZR RN Pyrrolo[2,3-a] carbazoles and use thereof as PIM kinase inhibitors. US8481586. DM6U3ZR RU http://www.freepatentsonline.com/US8481586.html DM5W0A2 DI DM5W0A2 DM5W0A2 DN US8481586, 5 DM5W0A2 MI TTCGOIN DM5W0A2 MN PIM-3 protein kinase (PIM3) DM5W0A2 MT DTT DM5W0A2 MA Inhibitor DM5W0A2 RN Pyrrolo[2,3-a] carbazoles and use thereof as PIM kinase inhibitors. US8481586. DM5W0A2 RU http://www.freepatentsonline.com/US8481586.html DMV6FL8 DI DMV6FL8 DMV6FL8 DN US8481733, 106 DMV6FL8 MI TTIET93 DMV6FL8 MN Activated CDC42 kinase 1 (ACK-1) DMV6FL8 MT DTT DMV6FL8 MA Inhibitor DMV6FL8 RN Substituted imidazopyr- and imidazotri-azines. US8481733. DMV6FL8 RU http://www.freepatentsonline.com/US8481733.html DMZQIKL DI DMZQIKL DMZQIKL DN US8481733, 118 DMZQIKL MI TTIET93 DMZQIKL MN Activated CDC42 kinase 1 (ACK-1) DMZQIKL MT DTT DMZQIKL MA Inhibitor DMZQIKL RN Substituted imidazopyr- and imidazotri-azines. US8481733. DMZQIKL RU http://www.freepatentsonline.com/US8481733.html DM36R21 DI DM36R21 DM36R21 DN US8481733, 95 DM36R21 MI TTIET93 DM36R21 MN Activated CDC42 kinase 1 (ACK-1) DM36R21 MT DTT DM36R21 MA Inhibitor DM36R21 RN Substituted imidazopyr- and imidazotri-azines. US8481733. DM36R21 RU http://www.freepatentsonline.com/US8481733.html DMCJH4F DI DMCJH4F DMCJH4F DN US8524917, 10 DMCJH4F MI TTDYP7I DMCJH4F MN Sphingosine-1-phosphate receptor 3 (S1PR3) DMCJH4F MT DTT DMCJH4F MA Inhibitor DMCJH4F RN 6-substituted indole-3-carboxylic acid amide compounds having sphingosine-1-phosphate (S1P) receptor antagonist biological activity. US8524917. DMCJH4F RU http://www.freepatentsonline.com/US8524917.html DMETY0U DI DMETY0U DMETY0U DN US8524917, 11 DMETY0U MI TTDYP7I DMETY0U MN Sphingosine-1-phosphate receptor 3 (S1PR3) DMETY0U MT DTT DMETY0U MA Inhibitor DMETY0U RN S1P3 receptor inhibitors for treating pain. US8563594. DMETY0U RU http://www.freepatentsonline.com/US8563594.html DMZ2ECB DI DMZ2ECB DMZ2ECB DN US8524917, 12 DMZ2ECB MI TTDYP7I DMZ2ECB MN Sphingosine-1-phosphate receptor 3 (S1PR3) DMZ2ECB MT DTT DMZ2ECB MA Inhibitor DMZ2ECB RN S1P3 receptor inhibitors for treating pain. US8563594. DMZ2ECB RU http://www.freepatentsonline.com/US8563594.html DMRPD8U DI DMRPD8U DMRPD8U DN US8524917, 60 DMRPD8U MI TTDYP7I DMRPD8U MN Sphingosine-1-phosphate receptor 3 (S1PR3) DMRPD8U MT DTT DMRPD8U MA Inhibitor DMRPD8U RN 6-substituted indole-3-carboxylic acid amide compounds having sphingosine-1-phosphate (S1P) receptor antagonist biological activity. US8524917. DMRPD8U RU http://www.freepatentsonline.com/US8524917.html DMF9LNO DI DMF9LNO DMF9LNO DN US8536181, A41 DMF9LNO MI TT9ISBX DMF9LNO MN HIF-prolyl hydroxylase 2 (HPH-2) DMF9LNO MT DTT DMF9LNO MA Inhibitor DMF9LNO RN Prolyl hydroxylase inhibitors. US8536181. DMF9LNO RU http://www.freepatentsonline.com/US8536181.html DMZNF59 DI DMZNF59 DMZNF59 DN US8536181, C14 DMZNF59 MI TT9ISBX DMZNF59 MN HIF-prolyl hydroxylase 2 (HPH-2) DMZNF59 MT DTT DMZNF59 MA Inhibitor DMZNF59 RN Prolyl hydroxylase inhibitors. US8536181. DMZNF59 RU http://www.freepatentsonline.com/US8536181.html DMRTL63 DI DMRTL63 DMRTL63 DN US8536181, C17 DMRTL63 MI TT9ISBX DMRTL63 MN HIF-prolyl hydroxylase 2 (HPH-2) DMRTL63 MT DTT DMRTL63 MA Inhibitor DMRTL63 RN Methods for increasing the stabilization of hypoxia inducible factor-1 alpha. US8778412. DMRTL63 RU http://www.freepatentsonline.com/US8778412.html DMAM51Z DI DMAM51Z DMAM51Z DN US8536181, C35 DMAM51Z MI TT9ISBX DMAM51Z MN HIF-prolyl hydroxylase 2 (HPH-2) DMAM51Z MT DTT DMAM51Z MA Inhibitor DMAM51Z RN Prolyl hydroxylase inhibitors. US8536181. DMAM51Z RU http://www.freepatentsonline.com/US8536181.html DMQRO6G DI DMQRO6G DMQRO6G DN US8546370, 102 DMQRO6G MI TTUMHT8 DMQRO6G MN Tyrosine-protein kinase ZAP-70 (ZAP-70) DMQRO6G MT DTT DMQRO6G MA Inhibitor DMQRO6G RN Compounds and compositions as kinase inhibitors. US8546370. DMQRO6G RU http://www.freepatentsonline.com/US8546370.html DM2K6YU DI DM2K6YU DM2K6YU DN US8546370, 11 DM2K6YU MI TTUMHT8 DM2K6YU MN Tyrosine-protein kinase ZAP-70 (ZAP-70) DM2K6YU MT DTT DM2K6YU MA Inhibitor DM2K6YU RN Compounds and compositions as kinase inhibitors. US8546370. DM2K6YU RU http://www.freepatentsonline.com/US8546370.html DMGIJZA DI DMGIJZA DMGIJZA DN US8546370, 17 DMGIJZA MI TTUMHT8 DMGIJZA MN Tyrosine-protein kinase ZAP-70 (ZAP-70) DMGIJZA MT DTT DMGIJZA MA Inhibitor DMGIJZA RN Compounds and compositions as kinase inhibitors. US8546370. DMGIJZA RU http://www.freepatentsonline.com/US8546370.html DMDP87V DI DMDP87V DMDP87V DN US8563594, 152 DMDP87V MI TTDYP7I DMDP87V MN Sphingosine-1-phosphate receptor 3 (S1PR3) DMDP87V MT DTT DMDP87V MA Inhibitor DMDP87V RN S1P3 receptor inhibitors for treating pain. US8563594. DMDP87V RU http://www.freepatentsonline.com/US8563594.html DMZV6YT DI DMZV6YT DMZV6YT DN US8569313, Inhibitor 14 DMZV6YT MI TTPRO7W DMZV6YT MN Suppressor of tumorigenicity 14 protein (ST14) DMZV6YT MT DTT DMZV6YT MA Inhibitor DMZV6YT RN Meta-substituted phenyl sulfonyl amides of secondary amino acid amides, the production thereof, and use thereof as matriptase inhibitors. US8569313. DMZV6YT RU http://www.freepatentsonline.com/US8569313.html DMTMG02 DI DMTMG02 DMTMG02 DN US8569313, Inhibitor 15 DMTMG02 MI TTPRO7W DMTMG02 MN Suppressor of tumorigenicity 14 protein (ST14) DMTMG02 MT DTT DMTMG02 MA Inhibitor DMTMG02 RN Meta-substituted phenyl sulfonyl amides of secondary amino acid amides, the production thereof, and use thereof as matriptase inhibitors. US8569313. DMTMG02 RU http://www.freepatentsonline.com/US8569313.html DMXTCGM DI DMXTCGM DMXTCGM DN US8569313, Inhibitor 18 DMXTCGM MI TTPRO7W DMXTCGM MN Suppressor of tumorigenicity 14 protein (ST14) DMXTCGM MT DTT DMXTCGM MA Inhibitor DMXTCGM RN Meta-substituted phenyl sulfonyl amides of secondary amino acid amides, the production thereof, and use thereof as matriptase inhibitors. US8569313. DMXTCGM RU http://www.freepatentsonline.com/US8569313.html DMLXG43 DI DMLXG43 DMLXG43 DN US8569313, Inhibitor 19 DMLXG43 MI TTPRO7W DMLXG43 MN Suppressor of tumorigenicity 14 protein (ST14) DMLXG43 MT DTT DMLXG43 MA Inhibitor DMLXG43 RN Meta-substituted phenyl sulfonyl amides of secondary amino acid amides, the production thereof, and use thereof as matriptase inhibitors. US8569313. DMLXG43 RU http://www.freepatentsonline.com/US8569313.html DMKLJ6O DI DMKLJ6O DMKLJ6O DN US8586571, 12 DMKLJ6O MI TT0C8BY DMKLJ6O MN Plasma retinol-binding protein (RBP4) DMKLJ6O MT DTT DMKLJ6O MA Inhibitor DMKLJ6O RN Heterocyclic compound. US8586571. DMKLJ6O RU http://www.freepatentsonline.com/US8586571.html DMX3A0O DI DMX3A0O DMX3A0O DN US8586571, 36 DMX3A0O MI TT0C8BY DMX3A0O MN Plasma retinol-binding protein (RBP4) DMX3A0O MT DTT DMX3A0O MA Inhibitor DMX3A0O RN Heterocyclic compound. US8586571. DMX3A0O RU http://www.freepatentsonline.com/US8586571.html DM1N74R DI DM1N74R DM1N74R DN US8586571, 6 DM1N74R MI TT0C8BY DM1N74R MN Plasma retinol-binding protein (RBP4) DM1N74R MT DTT DM1N74R MA Inhibitor DM1N74R RN Heterocyclic compound. US8586571. DM1N74R RU http://www.freepatentsonline.com/US8586571.html DM29KS1 DI DM29KS1 DM29KS1 DN US8592431, 181 DM29KS1 MI TTLJKZ0 DM29KS1 MN Acetyl-CoA transporter (SLC33A1) DM29KS1 MT DTT DM29KS1 MA Inhibitor DM29KS1 RN Fused ring compound and use thereof. US8592431. DM29KS1 RU http://www.freepatentsonline.com/US8592431.html DM1K5HS DI DM1K5HS DM1K5HS DN US8592431, 185 DM1K5HS MI TTLJKZ0 DM1K5HS MN Acetyl-CoA transporter (SLC33A1) DM1K5HS MT DTT DM1K5HS MA Inhibitor DM1K5HS RN Fused ring compound and use thereof. US8592431. DM1K5HS RU http://www.freepatentsonline.com/US8592431.html DMAPGBF DI DMAPGBF DMAPGBF DN US8592431, 457 DMAPGBF MI TTLJKZ0 DMAPGBF MN Acetyl-CoA transporter (SLC33A1) DMAPGBF MT DTT DMAPGBF MA Inhibitor DMAPGBF RN Fused ring compound and use thereof. US8592431. DMAPGBF RU http://www.freepatentsonline.com/US8592431.html DMY8U6J DI DMY8U6J DMY8U6J DN US8592455, 3 DMY8U6J MI TTCGOIN DMY8U6J MN PIM-3 protein kinase (PIM3) DMY8U6J MT DTT DMY8U6J MA Inhibitor DMY8U6J RN Kinase inhibitors and methods of their use. US8592455. DMY8U6J RU http://www.freepatentsonline.com/US8592455.html DMTE8QO DI DMTE8QO DMTE8QO DN US8592455, 90 DMTE8QO MI TTCGOIN DMTE8QO MN PIM-3 protein kinase (PIM3) DMTE8QO MT DTT DMTE8QO MA Inhibitor DMTE8QO RN Kinase inhibitors and methods of their use. US8592455. DMTE8QO RU http://www.freepatentsonline.com/US8592455.html DM0YD3Z DI DM0YD3Z DM0YD3Z DN US8598172, 1 DM0YD3Z MI TT976FS DM0YD3Z MN Polo-like kinase 2 (PLK2) DM0YD3Z MT DTT DM0YD3Z MA Inhibitor DM0YD3Z RN Substituted dihydropteridin-6-one derivatives, process for their preparation and their use as kinase inhibitors. US8598172. DM0YD3Z RU http://www.freepatentsonline.com/US8598172.html DM9YI3K DI DM9YI3K DM9YI3K DN US8598210, Table XV, 1 DM9YI3K MI TT9ISBX DM9YI3K MN HIF-prolyl hydroxylase 2 (HPH-2) DM9YI3K MT DTT DM9YI3K MA Inhibitor DM9YI3K RN Prolyl hydroxylase inhibitors and methods of use. US8598210. DM9YI3K RU http://www.freepatentsonline.com/US8598210.html DMDK98P DI DMDK98P DMDK98P DN US8598210, Table XV, 2 DMDK98P MI TT9ISBX DMDK98P MN HIF-prolyl hydroxylase 2 (HPH-2) DMDK98P MT DTT DMDK98P MA Inhibitor DMDK98P RN Prolyl hydroxylase inhibitors and methods of use. US9598370. DMDK98P RU http://www.freepatentsonline.com/US9598370.html DM3XWMO DI DM3XWMO DM3XWMO DN US8598210, Table XV, 4 DM3XWMO MI TT9ISBX DM3XWMO MN HIF-prolyl hydroxylase 2 (HPH-2) DM3XWMO MT DTT DM3XWMO MA Inhibitor DM3XWMO RN Prolyl hydroxylase inhibitors and methods of use. US8598210. DM3XWMO RU http://www.freepatentsonline.com/US8598210.html DMEU5ST DI DMEU5ST DMEU5ST DN US8598210, Table XV, 5 DMEU5ST MI TT9ISBX DMEU5ST MN HIF-prolyl hydroxylase 2 (HPH-2) DMEU5ST MT DTT DMEU5ST MA Inhibitor DMEU5ST RN Prolyl hydroxylase inhibitors and method of use. US8722895. DMEU5ST RU http://www.freepatentsonline.com/US8722895.html DM5CULA DI DM5CULA DM5CULA DN US8609715, A-1 DM5CULA MI TTXL0GC DM5CULA MN Enteropeptidase (TMPRSS15) DM5CULA MT DTT DM5CULA MA Inhibitor DM5CULA RN Heteroarylcarboxylic acid ester derivative. US8609715. DM5CULA RU http://www.freepatentsonline.com/US8609715.html DMY9SFE DI DMY9SFE DMY9SFE DN US8609715, A-26 DMY9SFE MI TTXL0GC DMY9SFE MN Enteropeptidase (TMPRSS15) DMY9SFE MT DTT DMY9SFE MA Inhibitor DMY9SFE RN Heteroarylcarboxylic acid ester derivative. US8609715. DMY9SFE RU http://www.freepatentsonline.com/US8609715.html DMU26R7 DI DMU26R7 DMU26R7 DN US8609715, B-61 DMU26R7 MI TTXL0GC DMU26R7 MN Enteropeptidase (TMPRSS15) DMU26R7 MT DTT DMU26R7 MA Inhibitor DMU26R7 RN Heteroarylcarboxylic acid ester derivative. US8609715. DMU26R7 RU http://www.freepatentsonline.com/US8609715.html DMJKFVU DI DMJKFVU DMJKFVU DN US8614253, 29-1 DMJKFVU MI TTOJ9QL DMJKFVU MN Endoplasmic reticulum to nucleus signaling 1 (ERN1) DMJKFVU MT DTT DMJKFVU MA Inhibitor DMJKFVU RN IRE-1 inhibitors. US9241942. DMJKFVU RU http://www.freepatentsonline.com/US9241942.html DMVI83P DI DMVI83P DMVI83P DN US8614253, 29-19 DMVI83P MI TTOJ9QL DMVI83P MN Endoplasmic reticulum to nucleus signaling 1 (ERN1) DMVI83P MT DTT DMVI83P MA Inhibitor DMVI83P RN IRE-1 inhibitors. US9493435. DMVI83P RU http://www.freepatentsonline.com/US9493435.html DMRSP2M DI DMRSP2M DMRSP2M DN US8614253, 32-4 DMRSP2M MI TTOJ9QL DMRSP2M MN Endoplasmic reticulum to nucleus signaling 1 (ERN1) DMRSP2M MT DTT DMRSP2M MA Inhibitor DMRSP2M RN IRE-1 inhibitors. US9493435. DMRSP2M RU http://www.freepatentsonline.com/US9493435.html DMSQODK DI DMSQODK DMSQODK DN US8614253, 32-5 DMSQODK MI TTOJ9QL DMSQODK MN Endoplasmic reticulum to nucleus signaling 1 (ERN1) DMSQODK MT DTT DMSQODK MA Inhibitor DMSQODK RN IRE-1 inhibitors. US8614253. DMSQODK RU http://www.freepatentsonline.com/US8614253.html DM4G3OC DI DM4G3OC DM4G3OC DN US8669361, 102 DM4G3OC MI TTCGOIN DM4G3OC MN PIM-3 protein kinase (PIM3) DM4G3OC MT DTT DM4G3OC MA Inhibitor DM4G3OC RN Pyrazol-4-yl-heterocyclyl-carboxamide compounds and methods of use. US9573943. DM4G3OC RU http://www.freepatentsonline.com/US9573943.html DMC67G4 DI DMC67G4 DMC67G4 DN US8669361, 103 DMC67G4 MI TTCGOIN DMC67G4 MN PIM-3 protein kinase (PIM3) DMC67G4 MT DTT DMC67G4 MA Inhibitor DMC67G4 RN Pyrazol-4-yl-heterocyclyl-carboxamide compounds and methods of use. US8669361. DMC67G4 RU http://www.freepatentsonline.com/US8669361.html DMIZWM6 DI DMIZWM6 DMIZWM6 DN US8669361, 105 DMIZWM6 MI TTCGOIN DMIZWM6 MN PIM-3 protein kinase (PIM3) DMIZWM6 MT DTT DMIZWM6 MA Inhibitor DMIZWM6 RN Pyrazol-4-yl-heterocyclyl-carboxamide compounds and methods of use. US8669361. DMIZWM6 RU http://www.freepatentsonline.com/US8669361.html DMF8MIB DI DMF8MIB DMF8MIB DN US8669361, 107 DMF8MIB MI TTCGOIN DMF8MIB MN PIM-3 protein kinase (PIM3) DMF8MIB MT DTT DMF8MIB MA Inhibitor DMF8MIB RN Pyrazol-4-yl-heterocyclyl-carboxamide compounds and methods of use. US8669361. DMF8MIB RU http://www.freepatentsonline.com/US8669361.html DMKYNB0 DI DMKYNB0 DMKYNB0 DN US8703720, 15 DMKYNB0 MI TTO3NYT DMKYNB0 MN Galectin-1 (LGALS1) DMKYNB0 MT DTT DMKYNB0 MA Inhibitor DMKYNB0 RN Galactoside inhibitors of galectins. US8703720. DMKYNB0 RU http://www.freepatentsonline.com/US8703720.html DMFGIPR DI DMFGIPR DMFGIPR DN US8703720, Reference Compound 1 DMFGIPR MI TTO3NYT DMFGIPR MN Galectin-1 (LGALS1) DMFGIPR MT DTT DMFGIPR MA Inhibitor DMFGIPR RN Galactoside inhibitors of galectins. US8703720. DMFGIPR RU http://www.freepatentsonline.com/US8703720.html DM536FO DI DM536FO DM536FO DN US8703720, Reference Compound 2 DM536FO MI TTO3NYT DM536FO MN Galectin-1 (LGALS1) DM536FO MT DTT DM536FO MA Inhibitor DM536FO RN Galactoside inhibitors of galectins. US8703720. DM536FO RU http://www.freepatentsonline.com/US8703720.html DMCNAM9 DI DMCNAM9 DMCNAM9 DN US8710232, 1 DMCNAM9 MI TT4UJX5 DMCNAM9 MN Carboxypeptidase B1 (CPB1) DMCNAM9 MT DTT DMCNAM9 MA Inhibitor DMCNAM9 RN Imidazole derivatives used as TAFIa inhibitors. US8710232. DMCNAM9 RU http://www.freepatentsonline.com/US8710232.html DMCNS9T DI DMCNS9T DMCNS9T DN US8710232, 7 DMCNS9T MI TT4UJX5 DMCNS9T MN Carboxypeptidase B1 (CPB1) DMCNS9T MT DTT DMCNS9T MA Inhibitor DMCNS9T RN Imidazole derivatives used as TAFIa inhibitors. US8710232. DMCNS9T RU http://www.freepatentsonline.com/US8710232.html DM1MQ7J DI DM1MQ7J DM1MQ7J DN US8710232, 8 DM1MQ7J MI TT4UJX5 DM1MQ7J MN Carboxypeptidase B1 (CPB1) DM1MQ7J MT DTT DM1MQ7J MA Inhibitor DM1MQ7J RN Imidazole derivatives used as TAFIa inhibitors. US8710232. DM1MQ7J RU http://www.freepatentsonline.com/US8710232.html DMU9YPV DI DMU9YPV DMU9YPV DN US8741907-compound-3 DMU9YPV MI TTN34SQ DMU9YPV MN Phosphodiesterase 3B (PDE3B) DMU9YPV MT DTT DMU9YPV MA Inhibitor DMU9YPV RN Selective phosphodiesterase 9A inhibitors as medicaments for improving cognitive processes. US9067945. DMU9YPV RU http://www.freepatentsonline.com/US9067945.html DMSYD3X DI DMSYD3X DMSYD3X DN US8754233, (4-Benzothiazol-2-yl-1H-pyrazol-3-yl)-[2-(1H-imidazol-4-yl)-ethyl]-amine DMSYD3X MI TT7ALZG DMSYD3X MN Integrin-linked protein kinase 1 (ILK) DMSYD3X MT DTT DMSYD3X MA Inhibitor DMSYD3X RN Pyrazolylbenzothiazole derivatives and their use as therapeutic agents. US8754233. DMSYD3X RU http://www.freepatentsonline.com/US8754233.html DMJPQNH DI DMJPQNH DMJPQNH DN US8754233, 2-(3-Amino-1H-pyrazol-4-yl)-5-fluoro-benzothiazole-6-sulfonic acid amide DMJPQNH MI TT7ALZG DMJPQNH MN Integrin-linked protein kinase 1 (ILK) DMJPQNH MT DTT DMJPQNH MA Inhibitor DMJPQNH RN Pyrazolylbenzothiazole derivatives and their use as therapeutic agents. US8754233. DMJPQNH RU http://www.freepatentsonline.com/US8754233.html DMJY0CD DI DMJY0CD DMJY0CD DN US8754233, 4-(5-Fluoro-6-methoxy-benzothiazol-2-yl)-5-(2-fluoro-phenyl)-2H-pyrazol-3-ylamine DMJY0CD MI TT7ALZG DMJY0CD MN Integrin-linked protein kinase 1 (ILK) DMJY0CD MT DTT DMJY0CD MA Inhibitor DMJY0CD RN Pyrazolylbenzothiazole derivatives and their use as therapeutic agents. US8754233. DMJY0CD RU http://www.freepatentsonline.com/US8754233.html DMRHNIL DI DMRHNIL DMRHNIL DN US8759338, 1 DMRHNIL MI TTCGOIN DMRHNIL MN PIM-3 protein kinase (PIM3) DMRHNIL MT DTT DMRHNIL MA Inhibitor DMRHNIL RN Heterocyclic kinase inhibitors. US8759338. DMRHNIL RU http://www.freepatentsonline.com/US8759338.html DMXHN1V DI DMXHN1V DMXHN1V DN US8759338, 12 DMXHN1V MI TTCGOIN DMXHN1V MN PIM-3 protein kinase (PIM3) DMXHN1V MT DTT DMXHN1V MA Inhibitor DMXHN1V RN Heterocyclic kinase inhibitors. US8759338. DMXHN1V RU http://www.freepatentsonline.com/US8759338.html DMSBRHJ DI DMSBRHJ DMSBRHJ DN US8759338, 2 DMSBRHJ MI TTCGOIN DMSBRHJ MN PIM-3 protein kinase (PIM3) DMSBRHJ MT DTT DMSBRHJ MA Inhibitor DMSBRHJ RN Heterocyclic kinase inhibitors. US8759338. DMSBRHJ RU http://www.freepatentsonline.com/US8759338.html DM2J8IS DI DM2J8IS DM2J8IS DN US8772478, 1 DM2J8IS MI TTQICM2 DM2J8IS MN ADAM metallopeptidase 33 (ADAM33) DM2J8IS MT DTT DM2J8IS MA Inhibitor DM2J8IS RN Benzenesulfonamide compounds, method for synthesizing same, and use thereof in medicine as well as in cosmetics. US8772478. DM2J8IS RU http://www.freepatentsonline.com/US8772478.html DMFJD5L DI DMFJD5L DMFJD5L DN US8772478, 2 DMFJD5L MI TTQICM2 DMFJD5L MN ADAM metallopeptidase 33 (ADAM33) DMFJD5L MT DTT DMFJD5L MA Inhibitor DMFJD5L RN Benzenesulfonamide compounds, method for synthesizing same, and use thereof in medicine as well as in cosmetics. US8772478. DMFJD5L RU http://www.freepatentsonline.com/US8772478.html DMN4FRE DI DMN4FRE DMN4FRE DN US8772478, 3 DMN4FRE MI TTQICM2 DMN4FRE MN ADAM metallopeptidase 33 (ADAM33) DMN4FRE MT DTT DMN4FRE MA Inhibitor DMN4FRE RN Benzenesulfonamide compounds, method for synthesizing same, and use thereof in medicine as well as in cosmetics. US8772478. DMN4FRE RU http://www.freepatentsonline.com/US8772478.html DMHI6RZ DI DMHI6RZ DMHI6RZ DN US8772478, 5 DMHI6RZ MI TTQICM2 DMHI6RZ MN ADAM metallopeptidase 33 (ADAM33) DMHI6RZ MT DTT DMHI6RZ MA Inhibitor DMHI6RZ RN Benzenesulfonamide compounds, method for synthesizing same, and use thereof in medicine as well as in cosmetics. US8772478. DMHI6RZ RU http://www.freepatentsonline.com/US8772478.html DMUPRX2 DI DMUPRX2 DMUPRX2 DN US8791257, 17 DMUPRX2 MI TTR93NU DMUPRX2 MN Casein kinase II alpha prime (CSNK2A2) DMUPRX2 MT DTT DMUPRX2 MA Inhibitor DMUPRX2 RN Substituted pyrrolotriazines as protein kinase inhibitors. US8791257. DMUPRX2 RU http://www.freepatentsonline.com/US8791257.html DMAEHCP DI DMAEHCP DMAEHCP DN US8791257, 38 DMAEHCP MI TTR93NU DMAEHCP MN Casein kinase II alpha prime (CSNK2A2) DMAEHCP MT DTT DMAEHCP MA Inhibitor DMAEHCP RN Substituted pyrrolotriazines as protein kinase inhibitors. US8791257. DMAEHCP RU http://www.freepatentsonline.com/US8791257.html DMIQO8N DI DMIQO8N DMIQO8N DN US8791257, 4 DMIQO8N MI TTR93NU DMIQO8N MN Casein kinase II alpha prime (CSNK2A2) DMIQO8N MT DTT DMIQO8N MA Inhibitor DMIQO8N RN Substituted pyrrolotriazines as protein kinase inhibitors. US8791257. DMIQO8N RU http://www.freepatentsonline.com/US8791257.html DMWKDET DI DMWKDET DMWKDET DN US8829193, 1 DMWKDET MI TTCGOIN DMWKDET MN PIM-3 protein kinase (PIM3) DMWKDET MT DTT DMWKDET MA Inhibitor DMWKDET RN PIM kinase inhibitors and methods of their use. US8829193. DMWKDET RU http://www.freepatentsonline.com/US8829193.html DMBIAQD DI DMBIAQD DMBIAQD DN US8829193, 2 DMBIAQD MI TTCGOIN DMBIAQD MN PIM-3 protein kinase (PIM3) DMBIAQD MT DTT DMBIAQD MA Inhibitor DMBIAQD RN PIM kinase inhibitors and methods of their use. US8829193. DMBIAQD RU http://www.freepatentsonline.com/US8829193.html DM5ZGK3 DI DM5ZGK3 DM5ZGK3 DN US8829193, 3 DM5ZGK3 MI TTCGOIN DM5ZGK3 MN PIM-3 protein kinase (PIM3) DM5ZGK3 MT DTT DM5ZGK3 MA Inhibitor DM5ZGK3 RN PIM kinase inhibitors and methods of their use. US8829193. DM5ZGK3 RU http://www.freepatentsonline.com/US8829193.html DMRUTJZ DI DMRUTJZ DMRUTJZ DN US8846654, 11 DMRUTJZ MI TTIS4OW DMRUTJZ MN Phosphodiesterase 8 (PDE8) DMRUTJZ MT DTT DMRUTJZ MA Inhibitor DMRUTJZ RN Therapeutic applications in the cardiovascular field of quinazolinedione derivatives. US8846654. DMRUTJZ RU http://www.freepatentsonline.com/US8846654.html DMML258 DI DMML258 DMML258 DN US8846654, 251 DMML258 MI TTIS4OW DMML258 MN Phosphodiesterase 8 (PDE8) DMML258 MT DTT DMML258 MA Inhibitor DMML258 RN Therapeutic applications in the cardiovascular field of quinazolinedione derivatives. US8846654. DMML258 RU http://www.freepatentsonline.com/US8846654.html DMP3RCH DI DMP3RCH DMP3RCH DN US8846654, 294 DMP3RCH MI TTIS4OW DMP3RCH MN Phosphodiesterase 8 (PDE8) DMP3RCH MT DTT DMP3RCH MA Inhibitor DMP3RCH RN Therapeutic applications in the cardiovascular field of quinazolinedione derivatives. US8846654. DMP3RCH RU http://www.freepatentsonline.com/US8846654.html DMX8NLB DI DMX8NLB DMX8NLB DN US8853215, 3 DMX8NLB MI TT0C8BY DMX8NLB MN Plasma retinol-binding protein (RBP4) DMX8NLB MT DTT DMX8NLB MA Inhibitor DMX8NLB RN Derivatives of N-acyl-N-phenylpiperazine useful (inter alia) for the prophylaxis or treatment of diabetes. US8853215. DMX8NLB RU http://www.freepatentsonline.com/US8853215.html DMDN8P1 DI DMDN8P1 DMDN8P1 DN US8877733, 27 DMDN8P1 MI TTQFZWR DMDN8P1 MN Hepatitis C virus Core protein messenger RNA (HCV Core mRNA) DMDN8P1 MT DTT DMDN8P1 MA Inhibitor DMDN8P1 RN 1-substituted pyrimidine N-nucleoside analogs for antiviral treatment. US8877733. DMDN8P1 RU http://www.freepatentsonline.com/US8877733.html DMLY3RE DI DMLY3RE DMLY3RE DN US8877733, 28 DMLY3RE MI TTQFZWR DMLY3RE MN Hepatitis C virus Core protein messenger RNA (HCV Core mRNA) DMLY3RE MT DTT DMLY3RE MA Inhibitor DMLY3RE RN 1-substituted pyrimidine N-nucleoside analogs for antiviral treatment. US8877733. DMLY3RE RU http://www.freepatentsonline.com/US8877733.html DM8B1Q4 DI DM8B1Q4 DM8B1Q4 DN US8889672, 252-036-001 DM8B1Q4 MI TTUWGRA DM8B1Q4 MN Protein kinase C zeta (PRKCZ) DM8B1Q4 MT DTT DM8B1Q4 MA Inhibitor DM8B1Q4 RN Compounds, formulations, and methods of protein kinase C inhibition. US8889672. DM8B1Q4 RU http://www.freepatentsonline.com/US8889672.html DMKXRJ4 DI DMKXRJ4 DMKXRJ4 DN US8889696, 39 DMKXRJ4 MI TTUWGRA DMKXRJ4 MN Protein kinase C zeta (PRKCZ) DMKXRJ4 MT DTT DMKXRJ4 MA Inhibitor DMKXRJ4 RN Substituted pyrido[2,3-d]pyrimidin-7(8H)-ones and therapeutic uses thereof. US8889696. DMKXRJ4 RU http://www.freepatentsonline.com/US8889696.html DMSYUHK DI DMSYUHK DMSYUHK DN US8889696, Staurosporine DMSYUHK MI TTCGOIN DMSYUHK MN PIM-3 protein kinase (PIM3) DMSYUHK MT DTT DMSYUHK MA Inhibitor DMSYUHK RN Substituted pyrido[2,3-d]pyrimidin-7(8H)-ones and therapeutic uses thereof. US8889696. DMSYUHK RU http://www.freepatentsonline.com/US8889696.html DMEAUJT DI DMEAUJT DMEAUJT DN US8901295, F609 DMEAUJT MI TTNAFOU DMEAUJT MN Rotamase D (PPID) DMEAUJT MT DTT DMEAUJT MA Inhibitor DMEAUJT RN Inhibitors of cyclophilins and uses thereof. US8901295. DMEAUJT RU http://www.freepatentsonline.com/US8901295.html DMPICE1 DI DMPICE1 DMPICE1 DN US8901295, F673 DMPICE1 MI TTNAFOU DMPICE1 MN Rotamase D (PPID) DMPICE1 MT DTT DMPICE1 MA Inhibitor DMPICE1 RN Inhibitors of cyclophilins and uses thereof. US8901295. DMPICE1 RU http://www.freepatentsonline.com/US8901295.html DM34KXF DI DM34KXF DM34KXF DN US8921389, 1 DM34KXF MI TT9ISBX DM34KXF MN HIF-prolyl hydroxylase 2 (HPH-2) DM34KXF MT DTT DM34KXF MA Inhibitor DM34KXF RN Naphthyridine derivatives as inhibitors of Hypoxia inducible factor (HIF) hydroxylase. US9695170. DM34KXF RU http://www.freepatentsonline.com/US9695170.html DM8NE12 DI DM8NE12 DM8NE12 DN US8921389, 123 DM8NE12 MI TT9ISBX DM8NE12 MN HIF-prolyl hydroxylase 2 (HPH-2) DM8NE12 MT DTT DM8NE12 MA Inhibitor DM8NE12 RN Naphthyridine derivatives as inhibitors of hypoxia inducible factor (HIF) hydroxylase. US8921389. DM8NE12 RU http://www.freepatentsonline.com/US8921389.html DMX7KDR DI DMX7KDR DMX7KDR DN US8921389, 2 DMX7KDR MI TT9ISBX DMX7KDR MN HIF-prolyl hydroxylase 2 (HPH-2) DMX7KDR MT DTT DMX7KDR MA Inhibitor DMX7KDR RN Naphthyridine derivatives as inhibitors of Hypoxia inducible factor (HIF) hydroxylase. US9695170. DMX7KDR RU http://www.freepatentsonline.com/US9695170.html DME1A80 DI DME1A80 DME1A80 DN US8921389, 210 DME1A80 MI TT9ISBX DME1A80 MN HIF-prolyl hydroxylase 2 (HPH-2) DME1A80 MT DTT DME1A80 MA Inhibitor DME1A80 RN Naphthyridine derivatives as inhibitors of Hypoxia inducible factor (HIF) hydroxylase. US9695170. DME1A80 RU http://www.freepatentsonline.com/US9695170.html DMIY68N DI DMIY68N DMIY68N DN US8921389, 22 DMIY68N MI TT9ISBX DMIY68N MN HIF-prolyl hydroxylase 2 (HPH-2) DMIY68N MT DTT DMIY68N MA Inhibitor DMIY68N RN Naphthyridine derivatives as inhibitors of hypoxia inducible factor (HIF) hydroxylase. US8921389. DMIY68N RU http://www.freepatentsonline.com/US8921389.html DMG3T7E DI DMG3T7E DMG3T7E DN US8933095, 1 DMG3T7E MI TTT3IXG DMG3T7E MN Kynurenine oxoglutarate transaminase II (AADAT) DMG3T7E MT DTT DMG3T7E MA Inhibitor DMG3T7E RN KAT II inhibitors. US8933095. DMG3T7E RU http://www.freepatentsonline.com/US8933095.html DMZUNJ4 DI DMZUNJ4 DMZUNJ4 DN US8933095, 14 DMZUNJ4 MI TTT3IXG DMZUNJ4 MN Kynurenine oxoglutarate transaminase II (AADAT) DMZUNJ4 MT DTT DMZUNJ4 MA Inhibitor DMZUNJ4 RN KAT II inhibitors. US8598200. DMZUNJ4 RU http://www.freepatentsonline.com/US8598200.html DMRN5F4 DI DMRN5F4 DMRN5F4 DN US8933095, 16 DMRN5F4 MI TTT3IXG DMRN5F4 MN Kynurenine oxoglutarate transaminase II (AADAT) DMRN5F4 MT DTT DMRN5F4 MA Inhibitor DMRN5F4 RN KAT II inhibitors. US8933095. DMRN5F4 RU http://www.freepatentsonline.com/US8933095.html DMOZ4FS DI DMOZ4FS DMOZ4FS DN US8933095, 18 DMOZ4FS MI TTT3IXG DMOZ4FS MN Kynurenine oxoglutarate transaminase II (AADAT) DMOZ4FS MT DTT DMOZ4FS MA Inhibitor DMOZ4FS RN KAT II inhibitors. US8598200. DMOZ4FS RU http://www.freepatentsonline.com/US8598200.html DMPNCOL DI DMPNCOL DMPNCOL DN US8933228, 3 DMPNCOL MI TT42OGM DMPNCOL MN Hematopoietic cell kinase (HCK) DMPNCOL MT DTT DMPNCOL MA Inhibitor DMPNCOL RN Respiratory formulations and compounds for use therein. US8933228. DMPNCOL RU http://www.freepatentsonline.com/US8933228.html DMKEX51 DI DMKEX51 DMKEX51 DN US8933228, Ref 2 DMKEX51 MI TT42OGM DMKEX51 MN Hematopoietic cell kinase (HCK) DMKEX51 MT DTT DMKEX51 MA Inhibitor DMKEX51 RN 1-pyrazolyl-3-(4-((2-anilinopyrimidin-4-yl)oxy)napththalen-1-yl) ureas as P38 MAP knase inhibitors. US9724347. DMKEX51 RU http://www.freepatentsonline.com/US9724347.html DM6EMYB DI DM6EMYB DM6EMYB DN US8937193-compound-6b DM6EMYB MI TTGT9C7 DM6EMYB MN Bcl-2-related protein A1 (BCL2A1) DM6EMYB MT DTT DM6EMYB MA Inhibitor DM6EMYB RN Apogossypolone derivatives as anticancer agents. US8937193. DM6EMYB RU http://www.freepatentsonline.com/US8937193.html DMHZJEA DI DMHZJEA DMHZJEA DN US8937193-compound-7 DMHZJEA MI TTGT9C7 DMHZJEA MN Bcl-2-related protein A1 (BCL2A1) DMHZJEA MT DTT DMHZJEA MA Inhibitor DMHZJEA RN Apogossypolone derivatives as anticancer agents. US8937193. DMHZJEA RU http://www.freepatentsonline.com/US8937193.html DM3PU57 DI DM3PU57 DM3PU57 DN US8940736, 23 DM3PU57 MI TTR93NU DM3PU57 MN Casein kinase II alpha prime (CSNK2A2) DM3PU57 MT DTT DM3PU57 MA Inhibitor DM3PU57 RN Imidazotriazinecarbonitriles useful as kinase inhibitors. US8940736. DM3PU57 RU http://www.freepatentsonline.com/US8940736.html DMXY4SP DI DMXY4SP DMXY4SP DN US8940736, 6 DMXY4SP MI TTR93NU DMXY4SP MN Casein kinase II alpha prime (CSNK2A2) DMXY4SP MT DTT DMXY4SP MA Inhibitor DMXY4SP RN Imidazotriazinecarbonitriles useful as kinase inhibitors. US8940736. DMXY4SP RU http://www.freepatentsonline.com/US8940736.html DM9KSVI DI DM9KSVI DM9KSVI DN US8940736, 7 DM9KSVI MI TTR93NU DM9KSVI MN Casein kinase II alpha prime (CSNK2A2) DM9KSVI MT DTT DM9KSVI MA Inhibitor DM9KSVI RN Imidazotriazinecarbonitriles useful as kinase inhibitors. US8940736. DM9KSVI RU http://www.freepatentsonline.com/US8940736.html DM4S5DF DI DM4S5DF DM4S5DF DN US8975409, Comparative compound B DM4S5DF MI TTVSMOH DM4S5DF MN Sphingosine-1-phosphate receptor 2 (S1PR2) DM4S5DF MT DTT DM4S5DF MA Inhibitor DM4S5DF RN Phenyl derivative. US8975409. DM4S5DF RU http://www.freepatentsonline.com/US8975409.html DMVB42P DI DMVB42P DMVB42P DN US8975409, Example 13 DMVB42P MI TTVSMOH DMVB42P MN Sphingosine-1-phosphate receptor 2 (S1PR2) DMVB42P MT DTT DMVB42P MA Inhibitor DMVB42P RN Phenyl derivative. US8975409. DMVB42P RU http://www.freepatentsonline.com/US8975409.html DMJQOAE DI DMJQOAE DMJQOAE DN US8975409, Example 9(3) DMJQOAE MI TTVSMOH DMJQOAE MN Sphingosine-1-phosphate receptor 2 (S1PR2) DMJQOAE MT DTT DMJQOAE MA Inhibitor DMJQOAE RN Phenyl derivative. US8975409. DMJQOAE RU http://www.freepatentsonline.com/US8975409.html DM4MRP9 DI DM4MRP9 DM4MRP9 DN US8987457, 117 DM4MRP9 MI TTCGOIN DM4MRP9 MN PIM-3 protein kinase (PIM3) DM4MRP9 MT DTT DM4MRP9 MA Inhibitor DM4MRP9 RN Ring-substituted N-pyridinyl amides as kinase inhibitors. US8987457. DM4MRP9 RU http://www.freepatentsonline.com/US8987457.html DMAGNEH DI DMAGNEH DMAGNEH DN US8987457, 15 DMAGNEH MI TTCGOIN DMAGNEH MN PIM-3 protein kinase (PIM3) DMAGNEH MT DTT DMAGNEH MA Inhibitor DMAGNEH RN Ring-substituted N-pyridinyl amides as kinase inhibitors. US8987457. DMAGNEH RU http://www.freepatentsonline.com/US8987457.html DM0O8WS DI DM0O8WS DM0O8WS DN US8987457, 198 DM0O8WS MI TTCGOIN DM0O8WS MN PIM-3 protein kinase (PIM3) DM0O8WS MT DTT DM0O8WS MA Inhibitor DM0O8WS RN Ring-substituted N-pyridinyl amides as kinase inhibitors. US8987457. DM0O8WS RU http://www.freepatentsonline.com/US8987457.html DMBF1C0 DI DMBF1C0 DMBF1C0 DN US9006244, E1 DMBF1C0 MI TTECBXN DMBF1C0 MN Oxysterols receptor LXR-alpha (NR1H3) DMBF1C0 MT DTT DMBF1C0 MA Inhibitor DMBF1C0 RN Liver X receptor modulators. US9006244. DMBF1C0 RU http://www.freepatentsonline.com/US9006244.html DMPDF9B DI DMPDF9B DMPDF9B DN US9006244, E2a DMPDF9B MI TTECBXN DMPDF9B MN Oxysterols receptor LXR-alpha (NR1H3) DMPDF9B MT DTT DMPDF9B MA Inhibitor DMPDF9B RN Liver X receptor modulators. US9006244. DMPDF9B RU http://www.freepatentsonline.com/US9006244.html DMP0TBO DI DMP0TBO DMP0TBO DN US9006244, E2b DMP0TBO MI TTECBXN DMP0TBO MN Oxysterols receptor LXR-alpha (NR1H3) DMP0TBO MT DTT DMP0TBO MA Inhibitor DMP0TBO RN Liver X receptor modulators. US9006244. DMP0TBO RU http://www.freepatentsonline.com/US9006244.html DMPGY0M DI DMPGY0M DMPGY0M DN US9024044, 1 DMPGY0M MI TTXL0GC DMPGY0M MN Enteropeptidase (TMPRSS15) DMPGY0M MT DTT DMPGY0M MA Inhibitor DMPGY0M RN Heteroarylcarboxylic acid ester derivative. US9227949. DMPGY0M RU http://www.freepatentsonline.com/US9227949.html DMWRXS8 DI DMWRXS8 DMWRXS8 DN US9024044, 2 DMWRXS8 MI TTXL0GC DMWRXS8 MN Enteropeptidase (TMPRSS15) DMWRXS8 MT DTT DMWRXS8 MA Inhibitor DMWRXS8 RN Heteroarylcarboxylic acid ester derivative. US9655879. DMWRXS8 RU http://www.freepatentsonline.com/US9655879.html DMKNDMB DI DMKNDMB DMKNDMB DN US9024044, 3 DMKNDMB MI TTXL0GC DMKNDMB MN Enteropeptidase (TMPRSS15) DMKNDMB MT DTT DMKNDMB MA Inhibitor DMKNDMB RN Heteroarylcarboxylic acid ester derivative. US9024044. DMKNDMB RU http://www.freepatentsonline.com/US9024044.html DMANFK8 DI DMANFK8 DMANFK8 DN US9024044, 4 DMANFK8 MI TTXL0GC DMANFK8 MN Enteropeptidase (TMPRSS15) DMANFK8 MT DTT DMANFK8 MA Inhibitor DMANFK8 RN Heteroarylcarboxylic acid ester derivative. US9655879. DMANFK8 RU http://www.freepatentsonline.com/US9655879.html DMZKGOX DI DMZKGOX DMZKGOX DN US9024044, 62 DMZKGOX MI TTXL0GC DMZKGOX MN Enteropeptidase (TMPRSS15) DMZKGOX MT DTT DMZKGOX MA Inhibitor DMZKGOX RN Heteroarylcarboxylic acid ester derivative. US9024044. DMZKGOX RU http://www.freepatentsonline.com/US9024044.html DMDELNU DI DMDELNU DMDELNU DN US9040714, 155 DMDELNU MI TTOJ9QL DMDELNU MN Endoplasmic reticulum to nucleus signaling 1 (ERN1) DMDELNU MT DTT DMDELNU MA Inhibitor DMDELNU RN IRE-1 inhibitors. US9040714. DMDELNU RU http://www.freepatentsonline.com/US9040714.html DM53Z4I DI DM53Z4I DM53Z4I DN US9040714, 7 DM53Z4I MI TTOJ9QL DM53Z4I MN Endoplasmic reticulum to nucleus signaling 1 (ERN1) DM53Z4I MT DTT DM53Z4I MA Inhibitor DM53Z4I RN IRE-1 inhibitors. US9040714. DM53Z4I RU http://www.freepatentsonline.com/US9040714.html DM2Z43I DI DM2Z43I DM2Z43I DN US9073931, E1 DM2Z43I MI TTECBXN DM2Z43I MN Oxysterols receptor LXR-alpha (NR1H3) DM2Z43I MT DTT DM2Z43I MA Inhibitor DM2Z43I RN Liver X receptor modulators. US9073931. DM2Z43I RU http://www.freepatentsonline.com/US9073931.html DMK9FJG DI DMK9FJG DMK9FJG DN US9073931, E2 DMK9FJG MI TTECBXN DMK9FJG MN Oxysterols receptor LXR-alpha (NR1H3) DMK9FJG MT DTT DMK9FJG MA Inhibitor DMK9FJG RN Liver X receptor modulators. US9073931. DMK9FJG RU http://www.freepatentsonline.com/US9073931.html DMCYM8P DI DMCYM8P DMCYM8P DN US9073931, E3 DMCYM8P MI TTECBXN DMCYM8P MN Oxysterols receptor LXR-alpha (NR1H3) DMCYM8P MT DTT DMCYM8P MA Inhibitor DMCYM8P RN Liver X receptor modulators. US9073931. DMCYM8P RU http://www.freepatentsonline.com/US9073931.html DMZD1L5 DI DMZD1L5 DMZD1L5 DN US9073936, 1 DMZD1L5 MI TT3ZS42 DMZD1L5 MN Phosphodiesterase 1B (PDE1B) DMZD1L5 MT DTT DMZD1L5 MA Inhibitor DMZD1L5 RN Organic compounds. US9598426. DMZD1L5 RU http://www.freepatentsonline.com/US9598426.html DMZH3MX DI DMZH3MX DMZH3MX DN US9073936, 2 DMZH3MX MI TT3ZS42 DMZH3MX MN Phosphodiesterase 1B (PDE1B) DMZH3MX MT DTT DMZH3MX MA Inhibitor DMZH3MX RN Organic compounds. US9598426. DMZH3MX RU http://www.freepatentsonline.com/US9598426.html DMS9W6O DI DMS9W6O DMS9W6O DN US9073936, 3 DMS9W6O MI TT3ZS42 DMS9W6O MN Phosphodiesterase 1B (PDE1B) DMS9W6O MT DTT DMS9W6O MA Inhibitor DMS9W6O RN Organic compounds. US9598426. DMS9W6O RU http://www.freepatentsonline.com/US9598426.html DM8UOKE DI DM8UOKE DM8UOKE DN US9096594, 3 DM8UOKE MI TTFQEMX DM8UOKE MN Casein kinase I alpha (CSNK1A1) DM8UOKE MT DTT DM8UOKE MA Inhibitor DM8UOKE RN Kinase inhibitors and methods of use thereof. US9096594. DM8UOKE RU http://www.freepatentsonline.com/US9096594.html DMPT2ZS DI DMPT2ZS DMPT2ZS DN US9108950, 1 DMPT2ZS MI TT42OGM DMPT2ZS MN Hematopoietic cell kinase (HCK) DMPT2ZS MT DTT DMPT2ZS MA Inhibitor DMPT2ZS RN 1-pyrazolyl-3-(4-((2-anilinopyrimidin-4-yl)oxy)napththalen-1-yl) ureas as p38 MAP kinase inhibitors. US9108950. DMPT2ZS RU http://www.freepatentsonline.com/US9108950.html DMKLYCV DI DMKLYCV DMKLYCV DN US9127005, P0L DMKLYCV MI TT3T17P DMKLYCV MN Phospholipase D1 (PLD1) DMKLYCV MT DTT DMKLYCV MA Inhibitor DMKLYCV RN Isoform selective phospholipase D inhibitors. US9127005. DMKLYCV RU http://www.freepatentsonline.com/US9127005.html DM3R7BT DI DM3R7BT DM3R7BT DN US9127005, P2B DM3R7BT MI TT3T17P DM3R7BT MN Phospholipase D1 (PLD1) DM3R7BT MT DTT DM3R7BT MA Inhibitor DM3R7BT RN Isoform selective phospholipase D inhibitors. US9127005. DM3R7BT RU http://www.freepatentsonline.com/US9127005.html DMMT98V DI DMMT98V DMMT98V DN US9127005, P2C DMMT98V MI TT3T17P DMMT98V MN Phospholipase D1 (PLD1) DMMT98V MT DTT DMMT98V MA Inhibitor DMMT98V RN Isoform selective phospholipase D inhibitors. US9127005. DMMT98V RU http://www.freepatentsonline.com/US9127005.html DM9RIF4 DI DM9RIF4 DM9RIF4 DN US9132129, Cpd002 DM9RIF4 MI TTH9LDP DM9RIF4 MN PC4 and SFRS1-interacting protein (PSIP1) DM9RIF4 MT DTT DM9RIF4 MA Inhibitor DM9RIF4 RN Antiviral compounds. US9132129. DM9RIF4 RU http://www.freepatentsonline.com/US9132129.html DMG18XH DI DMG18XH DMG18XH DN US9132129, Cpd023 DMG18XH MI TTH9LDP DMG18XH MN PC4 and SFRS1-interacting protein (PSIP1) DMG18XH MT DTT DMG18XH MA Inhibitor DMG18XH RN Antiviral compounds. US9132129. DMG18XH RU http://www.freepatentsonline.com/US9132129.html DM17YHP DI DM17YHP DM17YHP DN US9132129, Cpd047 DM17YHP MI TTH9LDP DM17YHP MN PC4 and SFRS1-interacting protein (PSIP1) DM17YHP MT DTT DM17YHP MA Inhibitor DM17YHP RN Antiviral compounds. US9132129. DM17YHP RU http://www.freepatentsonline.com/US9132129.html DMT6HXB DI DMT6HXB DMT6HXB DN US9156852, 1 DMT6HXB MI TTU98HG DMT6HXB MN Discoidin domain-containing receptor 2 (DDR2) DMT6HXB MT DTT DMT6HXB MA Inhibitor DMT6HXB RN Thieno[3,2-D]pyrimidine derivatives having inhibitory activity for protein kinases. US9156852. DMT6HXB RU http://www.freepatentsonline.com/US9156852.html DMZ1RMA DI DMZ1RMA DMZ1RMA DN US9156852, 105 DMZ1RMA MI TTU98HG DMZ1RMA MN Discoidin domain-containing receptor 2 (DDR2) DMZ1RMA MT DTT DMZ1RMA MA Inhibitor DMZ1RMA RN Thieno[3,2-D]pyrimidine derivatives having inhibitory activity for protein kinases. US9156852. DMZ1RMA RU http://www.freepatentsonline.com/US9156852.html DMFSOQY DI DMFSOQY DMFSOQY DN US9156852, 38 DMFSOQY MI TTU98HG DMFSOQY MN Discoidin domain-containing receptor 2 (DDR2) DMFSOQY MT DTT DMFSOQY MA Inhibitor DMFSOQY RN Thieno[3,2-D]pyrimidine derivatives having inhibitory activity for protein kinases. US9156852. DMFSOQY RU http://www.freepatentsonline.com/US9156852.html DM1K5T0 DI DM1K5T0 DM1K5T0 DN US9156852, 83 DM1K5T0 MI TTI1FPZ DM1K5T0 MN Epithelial discoidin domain receptor 1 (DDR1) DM1K5T0 MT DTT DM1K5T0 MA Inhibitor DM1K5T0 RN Thieno[3,2-D]pyrimidine derivatives having inhibitory activity for protein kinases. US9156852. DM1K5T0 RU http://www.freepatentsonline.com/US9156852.html DMOKG3Q DI DMOKG3Q DMOKG3Q DN US9181182, 34 DMOKG3Q MI TTDYP7I DMOKG3Q MN Sphingosine-1-phosphate receptor 3 (S1PR3) DMOKG3Q MT DTT DMOKG3Q MA Inhibitor DMOKG3Q RN S1P receptors modulators. US9181182. DMOKG3Q RU http://www.freepatentsonline.com/US9181182.html DM3QIF4 DI DM3QIF4 DM3QIF4 DN US9181182, 40 DM3QIF4 MI TTDYP7I DM3QIF4 MN Sphingosine-1-phosphate receptor 3 (S1PR3) DM3QIF4 MT DTT DM3QIF4 MA Inhibitor DM3QIF4 RN S1P receptors modulators. US9181182. DM3QIF4 RU http://www.freepatentsonline.com/US9181182.html DM4OHB5 DI DM4OHB5 DM4OHB5 DN US9181182, 47 DM4OHB5 MI TTDYP7I DM4OHB5 MN Sphingosine-1-phosphate receptor 3 (S1PR3) DM4OHB5 MT DTT DM4OHB5 MA Inhibitor DM4OHB5 RN S1P receptors modulators. US9181182. DM4OHB5 RU http://www.freepatentsonline.com/US9181182.html DMVFBHD DI DMVFBHD DMVFBHD DN US9187437, 24 DMVFBHD MI TTDYP7I DMVFBHD MN Sphingosine-1-phosphate receptor 3 (S1PR3) DMVFBHD MT DTT DMVFBHD MA Inhibitor DMVFBHD RN Substituted oxadiazole compounds. US9187437. DMVFBHD RU http://www.freepatentsonline.com/US9187437.html DM2ULB8 DI DM2ULB8 DM2ULB8 DN US9187437, 38 DM2ULB8 MI TTDYP7I DM2ULB8 MN Sphingosine-1-phosphate receptor 3 (S1PR3) DM2ULB8 MT DTT DM2ULB8 MA Inhibitor DM2ULB8 RN Substituted oxadiazole compounds. US9187437. DM2ULB8 RU http://www.freepatentsonline.com/US9187437.html DMEHSR7 DI DMEHSR7 DMEHSR7 DN US9187437, 8 DMEHSR7 MI TTDYP7I DMEHSR7 MN Sphingosine-1-phosphate receptor 3 (S1PR3) DMEHSR7 MT DTT DMEHSR7 MA Inhibitor DMEHSR7 RN Substituted oxadiazole compounds. US9187437. DMEHSR7 RU http://www.freepatentsonline.com/US9187437.html DMCLHX5 DI DMCLHX5 DMCLHX5 DN US9200020, Table 3 compound 8 DMCLHX5 MI TTBL49X DMCLHX5 MN Plasmodium Hypoxanthine-guanine phosphoribosyltransferase (Malaria LACZ) DMCLHX5 MT DTT DMCLHX5 MA Inhibitor DMCLHX5 RN 6-oxopurine phosphoribosyltransferase inhibitors. US9200020. DMCLHX5 RU http://www.freepatentsonline.com/US9200020.html DMEARS2 DI DMEARS2 DMEARS2 DN US9200020, Table 3, Compound 1B DMEARS2 MI TTBL49X DMEARS2 MN Plasmodium Hypoxanthine-guanine phosphoribosyltransferase (Malaria LACZ) DMEARS2 MT DTT DMEARS2 MA Inhibitor DMEARS2 RN 6-oxopurine phosphoribosyltransferase inhibitors. US9200020. DMEARS2 RU http://www.freepatentsonline.com/US9200020.html DMXFB5Z DI DMXFB5Z DMXFB5Z DN US9200020, Table 3, Compound 2B DMXFB5Z MI TTBL49X DMXFB5Z MN Plasmodium Hypoxanthine-guanine phosphoribosyltransferase (Malaria LACZ) DMXFB5Z MT DTT DMXFB5Z MA Inhibitor DMXFB5Z RN 6-oxopurine phosphoribosyltransferase inhibitors. US9200020. DMXFB5Z RU http://www.freepatentsonline.com/US9200020.html DM3NE8J DI DM3NE8J DM3NE8J DN US9206139, 4 DM3NE8J MI TTYG6BU DM3NE8J MN Aggrecanase-1 (ADAMTS4) DM3NE8J MT DTT DM3NE8J MA Inhibitor DM3NE8J RN Aggrecanase inhibitors. US9206139. DM3NE8J RU http://www.freepatentsonline.com/US9206139.html DMB4JS7 DI DMB4JS7 DMB4JS7 DN US9206139, 5 DMB4JS7 MI TTYG6BU DMB4JS7 MN Aggrecanase-1 (ADAMTS4) DMB4JS7 MT DTT DMB4JS7 MA Inhibitor DMB4JS7 RN Aggrecanase inhibitors. US9206139. DMB4JS7 RU http://www.freepatentsonline.com/US9206139.html DMD803F DI DMD803F DMD803F DN US9216972, 132 DMD803F MI TTDYP7I DMD803F MN Sphingosine-1-phosphate receptor 3 (S1PR3) DMD803F MT DTT DMD803F MA Inhibitor DMD803F RN Tricyclic heterocyclic compounds. US9216972. DMD803F RU http://www.freepatentsonline.com/US9216972.html DM7AHQE DI DM7AHQE DM7AHQE DN US9216972, 61 DM7AHQE MI TTDYP7I DM7AHQE MN Sphingosine-1-phosphate receptor 3 (S1PR3) DM7AHQE MT DTT DM7AHQE MA Inhibitor DM7AHQE RN Tricyclic heterocyclic compounds. US9216972. DM7AHQE RU http://www.freepatentsonline.com/US9216972.html DMXR5SZ DI DMXR5SZ DMXR5SZ DN US9216972, 67 DMXR5SZ MI TTDYP7I DMXR5SZ MN Sphingosine-1-phosphate receptor 3 (S1PR3) DMXR5SZ MT DTT DMXR5SZ MA Inhibitor DMXR5SZ RN Tricyclic heterocyclic compounds. US9216972. DMXR5SZ RU http://www.freepatentsonline.com/US9216972.html DMKLCZF DI DMKLCZF DMKLCZF DN US9216972, 94 DMKLCZF MI TTDYP7I DMKLCZF MN Sphingosine-1-phosphate receptor 3 (S1PR3) DMKLCZF MT DTT DMKLCZF MA Inhibitor DMKLCZF RN Tricyclic heterocyclic compounds. US9216972. DMKLCZF RU http://www.freepatentsonline.com/US9216972.html DMSXG78 DI DMSXG78 DMSXG78 DN US9217012, 10 DMSXG78 MI TT405FP DMSXG78 MN FAP-1 messenger RNA (PTPN13 mRNA) DMSXG78 MT DTT DMSXG78 MA Inhibitor DMSXG78 RN Inhibitors of protein tyrosine phosphatases. US9217012. DMSXG78 RU http://www.freepatentsonline.com/US9217012.html DM8GW54 DI DM8GW54 DM8GW54 DN US9241942, 32-12 DM8GW54 MI TTOJ9QL DM8GW54 MN Endoplasmic reticulum to nucleus signaling 1 (ERN1) DM8GW54 MT DTT DM8GW54 MA Inhibitor DM8GW54 RN IRE-1 inhibitors. US9493435. DM8GW54 RU http://www.freepatentsonline.com/US9493435.html DMYUDCE DI DMYUDCE DMYUDCE DN US9266828, B DMYUDCE MI TTH9WF6 DMYUDCE MN Dibasic-processing enzyme (Furin) DMYUDCE MT DTT DMYUDCE MA Inhibitor DMYUDCE RN Inhibitors of Furin and other pro-protein convertases. US9266828. DMYUDCE RU http://www.freepatentsonline.com/US9266828.html DMQEL1W DI DMQEL1W DMQEL1W DN US9266828, C DMQEL1W MI TTH9WF6 DMQEL1W MN Dibasic-processing enzyme (Furin) DMQEL1W MT DTT DMQEL1W MA Inhibitor DMQEL1W RN Inhibitors of Furin and other pro-protein convertases. US9266828. DMQEL1W RU http://www.freepatentsonline.com/US9266828.html DMYUL2X DI DMYUL2X DMYUL2X DN US9266828, E DMYUL2X MI TTH9WF6 DMYUL2X MN Dibasic-processing enzyme (Furin) DMYUL2X MT DTT DMYUL2X MA Inhibitor DMYUL2X RN Inhibitors of Furin and other pro-protein convertases. US9266828. DMYUL2X RU http://www.freepatentsonline.com/US9266828.html DM0GOCZ DI DM0GOCZ DM0GOCZ DN US9340511, 2 DM0GOCZ MI TT9ISBX DM0GOCZ MN HIF-prolyl hydroxylase 2 (HPH-2) DM0GOCZ MT DTT DM0GOCZ MA Inhibitor DM0GOCZ RN Process for making isoquinoline compounds. US9708269. DM0GOCZ RU http://www.freepatentsonline.com/US9708269.html DMFQERG DI DMFQERG DMFQERG DN US9340511, 5 DMFQERG MI TT9ISBX DMFQERG MN HIF-prolyl hydroxylase 2 (HPH-2) DMFQERG MT DTT DMFQERG MA Inhibitor DMFQERG RN Process for making isoquinoline compounds. US9708269. DMFQERG RU http://www.freepatentsonline.com/US9708269.html DMRL0WA DI DMRL0WA DMRL0WA DN US9340511, 6 DMRL0WA MI TT9ISBX DMRL0WA MN HIF-prolyl hydroxylase 2 (HPH-2) DMRL0WA MT DTT DMRL0WA MA Inhibitor DMRL0WA RN Process for making isoquinoline compounds. US9340511. DMRL0WA RU http://www.freepatentsonline.com/US9340511.html DMC0PUI DI DMC0PUI DMC0PUI DN US9340511, 7 DMC0PUI MI TT9ISBX DMC0PUI MN HIF-prolyl hydroxylase 2 (HPH-2) DMC0PUI MT DTT DMC0PUI MA Inhibitor DMC0PUI RN Process for making isoquinoline compounds. US9708269. DMC0PUI RU http://www.freepatentsonline.com/US9708269.html DM5E9RH DI DM5E9RH DM5E9RH DN US9340574, 7 DM5E9RH MI TTWMKXP DM5E9RH MN Protein-tyrosine phosphatase eta (HPTP) DM5E9RH MT DTT DM5E9RH MA Inhibitor DM5E9RH RN Inhibitors of protein tyrosine phosphatases. US9340574. DM5E9RH RU http://www.freepatentsonline.com/US9340574.html DMSLBT3 DI DMSLBT3 DMSLBT3 DN US9346821, A-20 DMSLBT3 MI TTXL0GC DMSLBT3 MN Enteropeptidase (TMPRSS15) DMSLBT3 MT DTT DMSLBT3 MA Inhibitor DMSLBT3 RN Heterocyclic carboxylic acid ester derivative. US9346821. DMSLBT3 RU http://www.freepatentsonline.com/US9346821.html DMR6P8T DI DMR6P8T DMR6P8T DN US9346821, B-13 DMR6P8T MI TTXL0GC DMR6P8T MN Enteropeptidase (TMPRSS15) DMR6P8T MT DTT DMR6P8T MA Inhibitor DMR6P8T RN Heterocyclic carboxylic acid ester derivative. US9346821. DMR6P8T RU http://www.freepatentsonline.com/US9346821.html DMQ1LGV DI DMQ1LGV DMQ1LGV DN US9346821, B-42 DMQ1LGV MI TTXL0GC DMQ1LGV MN Enteropeptidase (TMPRSS15) DMQ1LGV MT DTT DMQ1LGV MA Inhibitor DMQ1LGV RN Heterocyclic carboxylic acid ester derivative. US9346821. DMQ1LGV RU http://www.freepatentsonline.com/US9346821.html DMWG98Z DI DMWG98Z DMWG98Z DN US9353089, 135 DMWG98Z MI TTXMNHO DMWG98Z MN Plasmodium Plasmepsin 2 (Malaria PLA2) DMWG98Z MT DTT DMWG98Z MA Inhibitor DMWG98Z RN Compositions and methods for the treatment of malaria. US9353089. DMWG98Z RU http://www.freepatentsonline.com/US9353089.html DMB4MJ0 DI DMB4MJ0 DMB4MJ0 DN US9353089, 327 DMB4MJ0 MI TTXMNHO DMB4MJ0 MN Plasmodium Plasmepsin 2 (Malaria PLA2) DMB4MJ0 MT DTT DMB4MJ0 MA Inhibitor DMB4MJ0 RN Compositions and methods for the treatment of malaria. US9353089. DMB4MJ0 RU http://www.freepatentsonline.com/US9353089.html DMK02LS DI DMK02LS DMK02LS DN US9353089, 330 DMK02LS MI TTXMNHO DMK02LS MN Plasmodium Plasmepsin 2 (Malaria PLA2) DMK02LS MT DTT DMK02LS MA Inhibitor DMK02LS RN Compositions and methods for the treatment of malaria. US9353089. DMK02LS RU http://www.freepatentsonline.com/US9353089.html DMA3OI4 DI DMA3OI4 DMA3OI4 DN US9359293, TA DMA3OI4 MI TTLKF5M DMA3OI4 MN NAD-dependent deacetylase sirtuin-2 (SIRT2) DMA3OI4 MT DTT DMA3OI4 MA Inhibitor DMA3OI4 RN Methods of treatment using modulators of SIRT2. US9359293. DMA3OI4 RU http://www.freepatentsonline.com/US9359293.html DMRQ2G4 DI DMRQ2G4 DMRQ2G4 DN US9359293, TB DMRQ2G4 MI TTLKF5M DMRQ2G4 MN NAD-dependent deacetylase sirtuin-2 (SIRT2) DMRQ2G4 MT DTT DMRQ2G4 MA Inhibitor DMRQ2G4 RN Methods of treatment using modulators of SIRT2. US9359293. DMRQ2G4 RU http://www.freepatentsonline.com/US9359293.html DM0NIB5 DI DM0NIB5 DM0NIB5 DN US9359293, TM DM0NIB5 MI TTLKF5M DM0NIB5 MN NAD-dependent deacetylase sirtuin-2 (SIRT2) DM0NIB5 MT DTT DM0NIB5 MA Inhibitor DM0NIB5 RN Methods of treatment using modulators of SIRT2. US9359293. DM0NIB5 RU http://www.freepatentsonline.com/US9359293.html DMSA86Y DI DMSA86Y DMSA86Y DN US9365572, 5 DMSA86Y MI TTYXEPL DMSA86Y MN Ribosomal protein S6 kinase alpha-5 (RSK5) DMSA86Y MT DTT DMSA86Y MA Inhibitor DMSA86Y RN PI3K and/or mTOR inhibitor. US9365572. DMSA86Y RU http://www.freepatentsonline.com/US9365572.html DMVL57U DI DMVL57U DMVL57U DN US9388139, 12 DMVL57U MI TTN34SQ DMVL57U MN Phosphodiesterase 3B (PDE3B) DMVL57U MT DTT DMVL57U MA Inhibitor DMVL57U RN Derivatives of celeboxib, use thereof and preparation thereof. US9388139. DMVL57U RU http://www.freepatentsonline.com/US9388139.html DMMFC0V DI DMMFC0V DMMFC0V DN US9409892, 136 DMMFC0V MI TT9ISBX DMMFC0V MN HIF-prolyl hydroxylase 2 (HPH-2) DMMFC0V MT DTT DMMFC0V MA Inhibitor DMMFC0V RN 4-hydroxy-isoquinoline compounds as HIF hydroxylase inhibitors. US9409892. DMMFC0V RU http://www.freepatentsonline.com/US9409892.html DMZJTSP DI DMZJTSP DMZJTSP DN US9409892, 148 DMZJTSP MI TT9ISBX DMZJTSP MN HIF-prolyl hydroxylase 2 (HPH-2) DMZJTSP MT DTT DMZJTSP MA Inhibitor DMZJTSP RN 4-hydroxy-isoquinoline compounds as HIF hydroxylase inhibitors. US9409892. DMZJTSP RU http://www.freepatentsonline.com/US9409892.html DMHF2OX DI DMHF2OX DMHF2OX DN US9409892, 19 DMHF2OX MI TT9ISBX DMHF2OX MN HIF-prolyl hydroxylase 2 (HPH-2) DMHF2OX MT DTT DMHF2OX MA Inhibitor DMHF2OX RN 4-hydroxy-isoquinoline compounds as HIF hydroxylase inhibitors. US9409892. DMHF2OX RU http://www.freepatentsonline.com/US9409892.html DMWAL5Q DI DMWAL5Q DMWAL5Q DN US9409892, 59 DMWAL5Q MI TT9ISBX DMWAL5Q MN HIF-prolyl hydroxylase 2 (HPH-2) DMWAL5Q MT DTT DMWAL5Q MA Inhibitor DMWAL5Q RN 4-hydroxy-isoquinoline compounds as HIF hydroxylase inhibitors. US9409892. DMWAL5Q RU http://www.freepatentsonline.com/US9409892.html DMV4AHL DI DMV4AHL DMV4AHL DN US9422240, 1-282 DMV4AHL MI TT9ISBX DMV4AHL MN HIF-prolyl hydroxylase 2 (HPH-2) DMV4AHL MT DTT DMV4AHL MA Inhibitor DMV4AHL RN Partially saturated nitrogen-containing heterocyclic compound. US9422240. DMV4AHL RU http://www.freepatentsonline.com/US9422240.html DM0S2UK DI DM0S2UK DM0S2UK DN US9422240, 1-286 DM0S2UK MI TT9ISBX DM0S2UK MN HIF-prolyl hydroxylase 2 (HPH-2) DM0S2UK MT DTT DM0S2UK MA Inhibitor DM0S2UK RN Partially saturated nitrogen-containing heterocyclic compound. US9422240. DM0S2UK RU http://www.freepatentsonline.com/US9422240.html DMST6IF DI DMST6IF DMST6IF DN US9422240, 1-297 DMST6IF MI TT9ISBX DMST6IF MN HIF-prolyl hydroxylase 2 (HPH-2) DMST6IF MT DTT DMST6IF MA Inhibitor DMST6IF RN Partially saturated nitrogen-containing heterocyclic compound. US9422240. DMST6IF RU http://www.freepatentsonline.com/US9422240.html DMH7DL5 DI DMH7DL5 DMH7DL5 DN US9422240, 1-298 DMH7DL5 MI TT9ISBX DMH7DL5 MN HIF-prolyl hydroxylase 2 (HPH-2) DMH7DL5 MT DTT DMH7DL5 MA Inhibitor DMH7DL5 RN Partially saturated nitrogen-containing heterocyclic compound. US9422240. DMH7DL5 RU http://www.freepatentsonline.com/US9422240.html DMS842X DI DMS842X DMS842X DN US9434725, 113 DMS842X MI TTCGOIN DMS842X MN PIM-3 protein kinase (PIM3) DMS842X MT DTT DMS842X MA Inhibitor DMS842X RN 5-azaindazole compounds and methods of use. US9434725. DMS842X RU http://www.freepatentsonline.com/US9434725.html DM6Z01B DI DM6Z01B DM6Z01B DN US9434725, 285 DM6Z01B MI TTCGOIN DM6Z01B MN PIM-3 protein kinase (PIM3) DM6Z01B MT DTT DM6Z01B MA Inhibitor DM6Z01B RN 5-azaindazole compounds and methods of use. US9434725. DM6Z01B RU http://www.freepatentsonline.com/US9434725.html DM316FB DI DM316FB DM316FB DN US9434725, 315 DM316FB MI TTCGOIN DM316FB MN PIM-3 protein kinase (PIM3) DM316FB MT DTT DM316FB MA Inhibitor DM316FB RN 5-azaindazole compounds and methods of use. US9434725. DM316FB RU http://www.freepatentsonline.com/US9434725.html DMIT0H3 DI DMIT0H3 DMIT0H3 DN US9434727, 120 DMIT0H3 MI TT0C8BY DMIT0H3 MN Plasma retinol-binding protein (RBP4) DMIT0H3 MT DTT DMIT0H3 MA Inhibitor DMIT0H3 RN Substituted 4-phenylpiperidines, their preparation and use. US9434727. DMIT0H3 RU http://www.freepatentsonline.com/US9434727.html DMC812I DI DMC812I DMC812I DN US9434727, 153 DMC812I MI TT0C8BY DMC812I MN Plasma retinol-binding protein (RBP4) DMC812I MT DTT DMC812I MA Inhibitor DMC812I RN Substituted 4-phenylpiperidines, their preparation and use. US9434727. DMC812I RU http://www.freepatentsonline.com/US9434727.html DMLPWK3 DI DMLPWK3 DMLPWK3 DN US9434727, 40 DMLPWK3 MI TT0C8BY DMLPWK3 MN Plasma retinol-binding protein (RBP4) DMLPWK3 MT DTT DMLPWK3 MA Inhibitor DMLPWK3 RN Substituted 4-phenylpiperidines, their preparation and use. US9777010. DMLPWK3 RU http://www.freepatentsonline.com/US9777010.html DM9HQXC DI DM9HQXC DM9HQXC DN US9434727, 63 DM9HQXC MI TT0C8BY DM9HQXC MN Plasma retinol-binding protein (RBP4) DM9HQXC MT DTT DM9HQXC MA Inhibitor DM9HQXC RN Substituted 4-phenylpiperidines, their preparation and use. US9434727. DM9HQXC RU http://www.freepatentsonline.com/US9434727.html DMCJG8Z DI DMCJG8Z DMCJG8Z DN US9434727, 93 DMCJG8Z MI TT0C8BY DMCJG8Z MN Plasma retinol-binding protein (RBP4) DMCJG8Z MT DTT DMCJG8Z MA Inhibitor DMCJG8Z RN Substituted 4-phenylpiperidines, their preparation and use. US10072016. DMCJG8Z RU http://www.freepatentsonline.com/US10072016.html DMVQ3IX DI DMVQ3IX DMVQ3IX DN US9453017, 1 DMVQ3IX MI TT3T17P DMVQ3IX MN Phospholipase D1 (PLD1) DMVQ3IX MT DTT DMVQ3IX MA Inhibitor DMVQ3IX RN Antiviral therapies with phospholipase D inhibitors. US9453017. DMVQ3IX RU http://www.freepatentsonline.com/US9453017.html DMPH05Y DI DMPH05Y DMPH05Y DN US9453017, 2 DMPH05Y MI TT3T17P DMPH05Y MN Phospholipase D1 (PLD1) DMPH05Y MT DTT DMPH05Y MA Inhibitor DMPH05Y RN Antiviral therapies with phospholipase D inhibitors. US9453017. DMPH05Y RU http://www.freepatentsonline.com/US9453017.html DMGPDEF DI DMGPDEF DMGPDEF DN US9475795, 19 DMGPDEF MI TTB9CIL DMGPDEF MN Prokineticin receptor-1 (PROKR1) DMGPDEF MT DTT DMGPDEF MA Inhibitor DMGPDEF RN Sulfonyl piperidine derivatives and their use for treating prokineticin mediated diseases. US9475795. DMGPDEF RU http://www.freepatentsonline.com/US9475795.html DM0ZDL3 DI DM0ZDL3 DM0ZDL3 DN US9475795, 80 DM0ZDL3 MI TTB9CIL DM0ZDL3 MN Prokineticin receptor-1 (PROKR1) DM0ZDL3 MT DTT DM0ZDL3 MA Inhibitor DM0ZDL3 RN Sulfonyl piperidine derivatives and their use for treating prokineticin mediated diseases. US9475795. DM0ZDL3 RU http://www.freepatentsonline.com/US9475795.html DMR6ODL DI DMR6ODL DMR6ODL DN US9475795, 89 DMR6ODL MI TTB9CIL DMR6ODL MN Prokineticin receptor-1 (PROKR1) DMR6ODL MT DTT DMR6ODL MA Inhibitor DMR6ODL RN Sulfonyl piperidine derivatives and their use for treating prokineticin mediated diseases. US9475795. DMR6ODL RU http://www.freepatentsonline.com/US9475795.html DM4MJ3U DI DM4MJ3U DM4MJ3U DN US9493447, 1001 DM4MJ3U MI TTIS4OW DM4MJ3U MN Phosphodiesterase 8 (PDE8) DM4MJ3U MT DTT DM4MJ3U MA Inhibitor DM4MJ3U RN Optically active PDE10 inhibitor. US9493447. DM4MJ3U RU http://www.freepatentsonline.com/US9493447.html DMC1YR5 DI DMC1YR5 DMC1YR5 DN US9493490, C DMC1YR5 MI TTAZ3MN DMC1YR5 MN Beta-adrenergic receptor kinase 1 (ADRBK1) DMC1YR5 MT DTT DMC1YR5 MA Inhibitor DMC1YR5 RN Boron-containing small molecules. US9493490. DMC1YR5 RU http://www.freepatentsonline.com/US9493490.html DMUVC25 DI DMUVC25 DMUVC25 DN US9493490, D DMUVC25 MI TTAZ3MN DMUVC25 MN Beta-adrenergic receptor kinase 1 (ADRBK1) DMUVC25 MT DTT DMUVC25 MA Inhibitor DMUVC25 RN Boron-containing small molecules. US9493490. DMUVC25 RU http://www.freepatentsonline.com/US9493490.html DMFCIGE DI DMFCIGE DMFCIGE DN US9493490, E DMFCIGE MI TTAZ3MN DMFCIGE MN Beta-adrenergic receptor kinase 1 (ADRBK1) DMFCIGE MT DTT DMFCIGE MA Inhibitor DMFCIGE RN Boron-containing small molecules. US9493490. DMFCIGE RU http://www.freepatentsonline.com/US9493490.html DMJDTSN DI DMJDTSN DMJDTSN DN US9493490, L DMJDTSN MI TTAZ3MN DMJDTSN MN Beta-adrenergic receptor kinase 1 (ADRBK1) DMJDTSN MT DTT DMJDTSN MA Inhibitor DMJDTSN RN Boron-containing small molecules. US9493490. DMJDTSN RU http://www.freepatentsonline.com/US9493490.html DMR1Z3I DI DMR1Z3I DMR1Z3I DN US9522888, 412 DMR1Z3I MI TTDYP7I DMR1Z3I MN Sphingosine-1-phosphate receptor 3 (S1PR3) DMR1Z3I MT DTT DMR1Z3I MA Inhibitor DMR1Z3I RN Substituted bicyclic compounds. US10166249. DMR1Z3I RU http://www.freepatentsonline.com/US10166249.html DM6UXZK DI DM6UXZK DM6UXZK DN US9522888, 575 DM6UXZK MI TTDYP7I DM6UXZK MN Sphingosine-1-phosphate receptor 3 (S1PR3) DM6UXZK MT DTT DM6UXZK MA Inhibitor DM6UXZK RN Substituted bicyclic compounds. US9522888. DM6UXZK RU http://www.freepatentsonline.com/US9522888.html DMG0QZ1 DI DMG0QZ1 DMG0QZ1 DN US9522888, 618 DMG0QZ1 MI TTDYP7I DMG0QZ1 MN Sphingosine-1-phosphate receptor 3 (S1PR3) DMG0QZ1 MT DTT DMG0QZ1 MA Inhibitor DMG0QZ1 RN Substituted bicyclic compounds. US10166249. DMG0QZ1 RU http://www.freepatentsonline.com/US10166249.html DMTRZI7 DI DMTRZI7 DMTRZI7 DN US9522888, 695 DMTRZI7 MI TTDYP7I DMTRZI7 MN Sphingosine-1-phosphate receptor 3 (S1PR3) DMTRZI7 MT DTT DMTRZI7 MA Inhibitor DMTRZI7 RN Substituted bicyclic compounds. US9522888. DMTRZI7 RU http://www.freepatentsonline.com/US9522888.html DM81MV6 DI DM81MV6 DM81MV6 DN US9567304, Compound F-54 DM81MV6 MI TTI1FPZ DM81MV6 MN Epithelial discoidin domain receptor 1 (DDR1) DM81MV6 MT DTT DM81MV6 MA Inhibitor DM81MV6 RN Quinazolinedione derivative. US9567304. DM81MV6 RU http://www.freepatentsonline.com/US9567304.html DMCGUNB DI DMCGUNB DMCGUNB DN US9567304, Compound N-9 DMCGUNB MI TTI1FPZ DMCGUNB MN Epithelial discoidin domain receptor 1 (DDR1) DMCGUNB MT DTT DMCGUNB MA Inhibitor DMCGUNB RN Quinazolinedione derivative. US9567304. DMCGUNB RU http://www.freepatentsonline.com/US9567304.html DMJ76RC DI DMJ76RC DMJ76RC DN US9580418, Example 11 DMJ76RC MI TTCGOIN DMJ76RC MN PIM-3 protein kinase (PIM3) DMJ76RC MT DTT DMJ76RC MA Inhibitor DMJ76RC RN Bicyclic aromatic carboxamide compounds useful as Pim kinase inhibitors. US9580418. DMJ76RC RU http://www.freepatentsonline.com/US9580418.html DMGH9B3 DI DMGH9B3 DMGH9B3 DN US9580418, Example 8 DMGH9B3 MI TTCGOIN DMGH9B3 MN PIM-3 protein kinase (PIM3) DMGH9B3 MT DTT DMGH9B3 MA Inhibitor DMGH9B3 RN Bicyclic aromatic carboxamide compounds useful as Pim kinase inhibitors. US9580418. DMGH9B3 RU http://www.freepatentsonline.com/US9580418.html DMERWUQ DI DMERWUQ DMERWUQ DN US9586942, 16 DMERWUQ MI TTYJRN5 DMERWUQ MN N-acetylglucosaminyltransferase I (NAGAT1) DMERWUQ MT DTT DMERWUQ MA Inhibitor DMERWUQ RN Aminotetraline and aminoindane derivatives, pharmaceutical compositions containing them, and their use in therapy. US9586942. DMERWUQ RU http://www.freepatentsonline.com/US9586942.html DMZ745J DI DMZ745J DMZ745J DN US9586942, 2 DMZ745J MI TTYJRN5 DMZ745J MN N-acetylglucosaminyltransferase I (NAGAT1) DMZ745J MT DTT DMZ745J MA Inhibitor DMZ745J RN Aminotetraline and aminoindane derivatives, pharmaceutical compositions containing them, and their use in therapy. US9586942. DMZ745J RU http://www.freepatentsonline.com/US9586942.html DMRXCYF DI DMRXCYF DMRXCYF DN US9586942, 3* DMRXCYF MI TTYJRN5 DMRXCYF MN N-acetylglucosaminyltransferase I (NAGAT1) DMRXCYF MT DTT DMRXCYF MA Inhibitor DMRXCYF RN Aminotetraline and aminoindane derivatives, pharmaceutical compositions containing them, and their use in therapy. US9586942. DMRXCYF RU http://www.freepatentsonline.com/US9586942.html DM2RE91 DI DM2RE91 DM2RE91 DN US9586945, 1 DM2RE91 MI TTYJRN5 DM2RE91 MN N-acetylglucosaminyltransferase I (NAGAT1) DM2RE91 MT DTT DM2RE91 MA Inhibitor DM2RE91 RN Aminochromane, aminothiochromane and amino-1,2,3,4-tetrahydroquinoline derivatives, pharmaceutical compositions containing them, and their use in therapy. US9586945. DM2RE91 RU http://www.freepatentsonline.com/US9586945.html DMKZC4V DI DMKZC4V DMKZC4V DN US9586945, 19a DMKZC4V MI TTYJRN5 DMKZC4V MN N-acetylglucosaminyltransferase I (NAGAT1) DMKZC4V MT DTT DMKZC4V MA Inhibitor DMKZC4V RN Aminochromane, aminothiochromane and amino-1,2,3,4-tetrahydroquinoline derivatives, pharmaceutical compositions containing them, and their use in therapy. US9586945. DMKZC4V RU http://www.freepatentsonline.com/US9586945.html DM6A8XJ DI DM6A8XJ DM6A8XJ DN US9586945, 5 DM6A8XJ MI TTYJRN5 DM6A8XJ MN N-acetylglucosaminyltransferase I (NAGAT1) DM6A8XJ MT DTT DM6A8XJ MA Inhibitor DM6A8XJ RN Aminochromane, aminothiochromane and amino-1,2,3,4-tetrahydroquinoline derivatives, pharmaceutical compositions containing them, and their use in therapy. US9586945. DM6A8XJ RU http://www.freepatentsonline.com/US9586945.html DMRVQ5Z DI DMRVQ5Z DMRVQ5Z DN US9598431, 1 DMRVQ5Z MI TTGB2LZ DMRVQ5Z MN RAR-related orphan receptor-beta (RORB) DMRVQ5Z MT DTT DMRVQ5Z MA Inhibitor DMRVQ5Z RN Compounds useful for inhibiting ROR-gamma-t. US9598431. DMRVQ5Z RU http://www.freepatentsonline.com/US9598431.html DMILY1P DI DMILY1P DMILY1P DN US9598431, 2 DMILY1P MI TTGB2LZ DMILY1P MN RAR-related orphan receptor-beta (RORB) DMILY1P MT DTT DMILY1P MA Inhibitor DMILY1P RN Compounds useful for inhibiting ROR-gamma-t. US9598431. DMILY1P RU http://www.freepatentsonline.com/US9598431.html DMRC4O7 DI DMRC4O7 DMRC4O7 DN US9598431, 3 DMRC4O7 MI TT1TYN7 DMRC4O7 MN Nuclear receptor ROR-alpha (RORA) DMRC4O7 MT DTT DMRC4O7 MA Inhibitor DMRC4O7 RN Compounds useful for inhibiting ROR-gamma-t. US9598431. DMRC4O7 RU http://www.freepatentsonline.com/US9598431.html DMXGF56 DI DMXGF56 DMXGF56 DN US9598431, 5 DMXGF56 MI TTGB2LZ DMXGF56 MN RAR-related orphan receptor-beta (RORB) DMXGF56 MT DTT DMXGF56 MA Inhibitor DMXGF56 RN Compounds useful for inhibiting ROR-gamma-t. US9598431. DMXGF56 RU http://www.freepatentsonline.com/US9598431.html DMSD354 DI DMSD354 DMSD354 DN US9611221, Example 9 DMSD354 MI TTIG67W DMSD354 MN Lysine-specific demethylase 5A (KDM5A) DMSD354 MT DTT DMSD354 MA Inhibitor DMSD354 RN Histone demethylase inhibitors. US9611221. DMSD354 RU http://www.freepatentsonline.com/US9611221.html DM89LKQ DI DM89LKQ DM89LKQ DN US9617250, Example 1 Example 204 of D1 DM89LKQ MI TTDYP7I DM89LKQ MN Sphingosine-1-phosphate receptor 3 (S1PR3) DM89LKQ MT DTT DM89LKQ MA Inhibitor DM89LKQ RN Pyridin-4-yl derivatives. US9617250. DM89LKQ RU http://www.freepatentsonline.com/US9617250.html DM6F7M2 DI DM6F7M2 DM6F7M2 DN US9623028, Compound 101 DM6F7M2 MI TTV298Y DM6F7M2 MN Calmodulin-dependent kinase II (CAMKK2) DM6F7M2 MT DTT DM6F7M2 MA Inhibitor DM6F7M2 RN Methods of treating a cancer using substituted pyrrolopyrimidine compounds, compositions thereof. US9623028. DM6F7M2 RU http://www.freepatentsonline.com/US9623028.html DMMSHX4 DI DMMSHX4 DMMSHX4 DN US9623028, Compound 79 DMMSHX4 MI TTV298Y DMMSHX4 MN Calmodulin-dependent kinase II (CAMKK2) DMMSHX4 MT DTT DMMSHX4 MA Inhibitor DMMSHX4 RN Methods of treating a cancer using substituted pyrrolopyrimidine compounds, compositions thereof. US9623028. DMMSHX4 RU http://www.freepatentsonline.com/US9623028.html DMR3Z49 DI DMR3Z49 DMR3Z49 DN US9650366, 12 DMR3Z49 MI TTXEZJ4 DMR3Z49 MN Tyrosine-protein kinase EIF2AK2 (p68) DMR3Z49 MT DTT DMR3Z49 MA Inhibitor DMR3Z49 RN Heterocycle-substituted pyridyl benzothiophenes as kinase inhibitors. US9650366. DMR3Z49 RU http://www.freepatentsonline.com/US9650366.html DM9HZ03 DI DM9HZ03 DM9HZ03 DN US9650366, 2 DM9HZ03 MI TTXEZJ4 DM9HZ03 MN Tyrosine-protein kinase EIF2AK2 (p68) DM9HZ03 MT DTT DM9HZ03 MA Inhibitor DM9HZ03 RN Heterocycle-substituted pyridyl benzothiophenes as kinase inhibitors. US9650366. DM9HZ03 RU http://www.freepatentsonline.com/US9650366.html DMUCIPE DI DMUCIPE DMUCIPE DN US9650366, 9 DMUCIPE MI TTXEZJ4 DMUCIPE MN Tyrosine-protein kinase EIF2AK2 (p68) DMUCIPE MT DTT DMUCIPE MA Inhibitor DMUCIPE RN Heterocycle-substituted pyridyl benzothiophenes as kinase inhibitors. US9650366. DMUCIPE RU http://www.freepatentsonline.com/US9650366.html DMXU8DI DI DMXU8DI DMXU8DI DN US9656955, Example 351 DMXU8DI MI TTYJRN5 DMXU8DI MN N-acetylglucosaminyltransferase I (NAGAT1) DMXU8DI MT DTT DMXU8DI MA Inhibitor DMXU8DI RN Pyrrolidine derivatives, pharmaceutical compositions containing them, and their use in therapy. US9656955. DMXU8DI RU http://www.freepatentsonline.com/US9656955.html DMC3Q9O DI DMC3Q9O DMC3Q9O DN US9656955, Example 540 DMC3Q9O MI TTYJRN5 DMC3Q9O MN N-acetylglucosaminyltransferase I (NAGAT1) DMC3Q9O MT DTT DMC3Q9O MA Inhibitor DMC3Q9O RN Pyrrolidine derivatives, pharmaceutical compositions containing them, and their use in therapy. US9656955. DMC3Q9O RU http://www.freepatentsonline.com/US9656955.html DMKS7D9 DI DMKS7D9 DMKS7D9 DN US9656955, Example 652 DMKS7D9 MI TTYJRN5 DMKS7D9 MN N-acetylglucosaminyltransferase I (NAGAT1) DMKS7D9 MT DTT DMKS7D9 MA Inhibitor DMKS7D9 RN Pyrrolidine derivatives, pharmaceutical compositions containing them, and their use in therapy. US9656955. DMKS7D9 RU http://www.freepatentsonline.com/US9656955.html DM9JCL2 DI DM9JCL2 DM9JCL2 DN US9670220, 33 DM9JCL2 MI TTDYP7I DM9JCL2 MN Sphingosine-1-phosphate receptor 3 (S1PR3) DM9JCL2 MT DTT DM9JCL2 MA Inhibitor DM9JCL2 RN Fused heterocyclic derivatives as S1P modulators. US9670220. DM9JCL2 RU http://www.freepatentsonline.com/US9670220.html DMNZD8T DI DMNZD8T DMNZD8T DN US9670220, 76 DMNZD8T MI TTDYP7I DMNZD8T MN Sphingosine-1-phosphate receptor 3 (S1PR3) DMNZD8T MT DTT DMNZD8T MA Inhibitor DMNZD8T RN Fused heterocyclic derivatives as S1P modulators. US9670220. DMNZD8T RU http://www.freepatentsonline.com/US9670220.html DMZG1HO DI DMZG1HO DMZG1HO DN US9670220, 77 DMZG1HO MI TTDYP7I DMZG1HO MN Sphingosine-1-phosphate receptor 3 (S1PR3) DMZG1HO MT DTT DMZG1HO MA Inhibitor DMZG1HO RN Fused heterocyclic derivatives as S1P modulators. US9670220. DMZG1HO RU http://www.freepatentsonline.com/US9670220.html DM6EQVT DI DM6EQVT DM6EQVT DN US9682983, 1 DM6EQVT MI TTPKHTZ DM6EQVT MN Activin receptor type IB (ACVR1B) DM6EQVT MT DTT DM6EQVT MA Inhibitor DM6EQVT RN BMP inhibitors and methods of use thereof. US9682983. DM6EQVT RU http://www.freepatentsonline.com/US9682983.html DM6R1YP DI DM6R1YP DM6R1YP DN US9682983, 33 DM6R1YP MI TTPKHTZ DM6R1YP MN Activin receptor type IB (ACVR1B) DM6R1YP MT DTT DM6R1YP MA Inhibitor DM6R1YP RN BMP inhibitors and methods of use thereof. US9682983. DM6R1YP RU http://www.freepatentsonline.com/US9682983.html DMVGQXK DI DMVGQXK DMVGQXK DN US9682991, 2 DMVGQXK MI TTCGOIN DMVGQXK MN PIM-3 protein kinase (PIM3) DMVGQXK MT DTT DMVGQXK MA Inhibitor DMVGQXK RN Tricyclic compounds for use as kinase inhibitors. US9682991. DMVGQXK RU http://www.freepatentsonline.com/US9682991.html DMGTIP6 DI DMGTIP6 DMGTIP6 DN US9682991, 23 DMGTIP6 MI TTCGOIN DMGTIP6 MN PIM-3 protein kinase (PIM3) DMGTIP6 MT DTT DMGTIP6 MA Inhibitor DMGTIP6 RN Tricyclic compounds for use as kinase inhibitors. US9682991. DMGTIP6 RU http://www.freepatentsonline.com/US9682991.html DM7SQKD DI DM7SQKD DM7SQKD DN US9682991, 7 DM7SQKD MI TTCGOIN DM7SQKD MN PIM-3 protein kinase (PIM3) DM7SQKD MT DTT DM7SQKD MA Inhibitor DM7SQKD RN Tricyclic compounds for use as kinase inhibitors. US9682991. DM7SQKD RU http://www.freepatentsonline.com/US9682991.html DMMCNVO DI DMMCNVO DMMCNVO DN US9694002, 129 DMMCNVO MI TTANOZH DMMCNVO MN SCN1A messenger RNA (SCN1A mRNA) DMMCNVO MT DTT DMMCNVO MA Inhibitor DMMCNVO RN Substituted benzamides and methods of use thereof. US9694002. DMMCNVO RU http://www.freepatentsonline.com/US9694002.html DMV1OR0 DI DMV1OR0 DMV1OR0 DN US9694002, 495 DMV1OR0 MI TTANOZH DMV1OR0 MN SCN1A messenger RNA (SCN1A mRNA) DMV1OR0 MT DTT DMV1OR0 MA Inhibitor DMV1OR0 RN Substituted benzamides and methods of use thereof. US9694002. DMV1OR0 RU http://www.freepatentsonline.com/US9694002.html DM804T5 DI DM804T5 DM804T5 DN US9694002, 59 DM804T5 MI TTANOZH DM804T5 MN SCN1A messenger RNA (SCN1A mRNA) DM804T5 MT DTT DM804T5 MA Inhibitor DM804T5 RN Substituted benzamides and methods of use thereof. US9694002. DM804T5 RU http://www.freepatentsonline.com/US9694002.html DMZF3AQ DI DMZF3AQ DMZF3AQ DN US9695118, 4 DMZF3AQ MI TTI1FPZ DMZF3AQ MN Epithelial discoidin domain receptor 1 (DDR1) DMZF3AQ MT DTT DMZF3AQ MA Inhibitor DMZF3AQ RN Benzamide derivative. US9695118. DMZF3AQ RU http://www.freepatentsonline.com/US9695118.html DMAD3VL DI DMAD3VL DMAD3VL DN US9695118, 8 DMAD3VL MI TTI1FPZ DMAD3VL MN Epithelial discoidin domain receptor 1 (DDR1) DMAD3VL MT DTT DMAD3VL MA Inhibitor DMAD3VL RN Benzamide derivative. US9695118. DMAD3VL RU http://www.freepatentsonline.com/US9695118.html DMSI09Y DI DMSI09Y DMSI09Y DN US9707205, 40 DMSI09Y MI TTDYP7I DMSI09Y MN Sphingosine-1-phosphate receptor 3 (S1PR3) DMSI09Y MT DTT DMSI09Y MA Inhibitor DMSI09Y RN S1P receptors modulators and their use thereof. US9707205. DMSI09Y RU http://www.freepatentsonline.com/US9707205.html DMEB59T DI DMEB59T DMEB59T DN US9714230, 12 DMEB59T MI TTIG67W DMEB59T MN Lysine-specific demethylase 5A (KDM5A) DMEB59T MT DTT DMEB59T MA Inhibitor DMEB59T RN Histone demethylase inhibitors. US9714230. DMEB59T RU http://www.freepatentsonline.com/US9714230.html DMPZS16 DI DMPZS16 DMPZS16 DN US9714230, 46 DMPZS16 MI TTIG67W DMPZS16 MN Lysine-specific demethylase 5A (KDM5A) DMPZS16 MT DTT DMPZS16 MA Inhibitor DMPZS16 RN Histone demethylase inhibitors. US9604961. DMPZS16 RU http://www.freepatentsonline.com/US9604961.html DMOVEZF DI DMOVEZF DMOVEZF DN VAPBGCRAUJRZPO-UHFFFAOYSA-N DMOVEZF MI TTI1FPZ DMOVEZF MN Epithelial discoidin domain receptor 1 (DDR1) DMOVEZF MT DTT DMOVEZF MA Inhibitor DMOVEZF RN Benzamide derivative. US9695118. DMOVEZF RU http://www.freepatentsonline.com/US9695118.html DMH9ION DI DMH9ION DMH9ION DN VFEDEOUBYBLDKN-AAFJCEBUSA-N DMH9ION MI TT5U49F DMH9ION MN PRKACA messenger RNA (PRKACA mRNA) DMH9ION MT DTT DMH9ION MA Inhibitor DMH9ION RN Purine derivatives. US8846696. DMH9ION RU http://www.freepatentsonline.com/US8846696.html DMTMFNK DI DMTMFNK DMTMFNK DN Vinyl sulfone derivative 1 DMTMFNK MI TT3Z6Y9 DMTMFNK MN Cysteines of Keap1 (KEAP1 Cysteines) DMTMFNK MT DTT DMTMFNK MA Modulator DMTMFNK RN Recent progress in the development of small molecule Nrf2 modulators: a patent review (2012-2016).Expert Opin Ther Pat. 2017 Jul;27(7):763-785. DMTMFNK RU https://www.ncbi.nlm.nih.gov/pubmed/28454500 DMTMFNK DI DMTMFNK DMTMFNK DN Vinyl sulfone derivative 1 DMTMFNK MI TTA6ZN2 DMTMFNK MN Nuclear factor erythroid 2-related factor 2 (Nrf2) DMTMFNK MT DTT DMTMFNK MA Activator DMTMFNK RN Recent progress in the development of small molecule Nrf2 modulators: a patent review (2012-2016).Expert Opin Ther Pat. 2017 Jul;27(7):763-785. DMTMFNK RU https://www.ncbi.nlm.nih.gov/pubmed/28454500 DML32R8 DI DML32R8 DML32R8 DN VX-148 DML32R8 MI TTL7C8Q DML32R8 MN Inosine-5'-monophosphate dehydrogenase 1 (IMPDH1) DML32R8 MT DTT DML32R8 MA Inhibitor DML32R8 RN Characterization of pharmacological efficacy of VX-148, a new, potent immunosuppressive inosine 5'-monophosphate dehydrogenase inhibitor. J Pharmacol Exp Ther. 2002 Sep;302(3):1272-7. DML32R8 RU https://pubmed.ncbi.nlm.nih.gov/12183689 DMIULVJ DI DMIULVJ DMIULVJ DN Xanthine derivative 1 DMIULVJ MI TTDIGC1 DMIULVJ MN Dipeptidyl peptidase 4 (DPP-4) DMIULVJ MT DTT DMIULVJ MA Inhibitor DMIULVJ RN DPP-4 inhibitors: a patent review (2012 - 2014).Expert Opin Ther Pat. 2015 Feb;25(2):209-36. DMIULVJ RU https://www.ncbi.nlm.nih.gov/pubmed/25482888 DMNXJ8G DI DMNXJ8G DMNXJ8G DN Xanthine/amino piperidine compound 1 DMNXJ8G MI TTDIGC1 DMNXJ8G MN Dipeptidyl peptidase 4 (DPP-4) DMNXJ8G MT DTT DMNXJ8G MA Inhibitor DMNXJ8G RN DPP-4 inhibitors: a patent review (2012 - 2014).Expert Opin Ther Pat. 2015 Feb;25(2):209-36. DMNXJ8G RU https://www.ncbi.nlm.nih.gov/pubmed/25482888 DM5Q93Y DI DM5Q93Y DM5Q93Y DN XHPNYYOUZWOWNT-PYUWXLGESA-N DM5Q93Y MI TT5U49F DM5Q93Y MN PRKACA messenger RNA (PRKACA mRNA) DM5Q93Y MT DTT DM5Q93Y MA Inhibitor DM5Q93Y RN Purine derivatives. US8846696. DM5Q93Y RU http://www.freepatentsonline.com/US8846696.html DMHAVYS DI DMHAVYS DMHAVYS DN Y-9680 DMHAVYS MI TTUWGRA DMHAVYS MN Protein kinase C zeta (PRKCZ) DMHAVYS MT DTT DMHAVYS MA Inhibitor DMHAVYS RN Compounds, formulations, and methods of protein kinase C inhibition. US8889672. DMHAVYS RU http://www.freepatentsonline.com/US8889672.html DMA91FM DI DMA91FM DMA91FM DN YYDJCLCSBYCSCO-UHFFFAOYSA-N DMA91FM MI TTDYP7I DMA91FM MN Sphingosine-1-phosphate receptor 3 (S1PR3) DMA91FM MT DTT DMA91FM MA Inhibitor DMA91FM RN 6-amino-pyrimidine-4-carboxamide derivatives and related compounds which bind to the sphingosine 1-phosphate (S1P) receptor for the treatment of multiple sclerosis. US9150519. DMA91FM RU http://www.freepatentsonline.com/US9150519.html DMUOZEJ DI DMUOZEJ DMUOZEJ DN Z223457004 DMUOZEJ MI TT3RMNA DMUOZEJ MN Chymotrypsin-C (CLCR) DMUOZEJ MT DTT DMUOZEJ MA Inhibitor DMUOZEJ RN Benzoxazinone derivatives for treatment of skin diseases. US9695194. DMUOZEJ RU http://www.freepatentsonline.com/US9695194.html DMRBFUA DI DMRBFUA DMRBFUA DN Z90308237 DMRBFUA MI TT3RMNA DMRBFUA MN Chymotrypsin-C (CLCR) DMRBFUA MT DTT DMRBFUA MA Inhibitor DMRBFUA RN Benzoxazinone derivatives for treatment of skin diseases. US9695194. DMRBFUA RU http://www.freepatentsonline.com/US9695194.html DMLZDAK DI DMLZDAK DMLZDAK DN ZINC19658740 DMLZDAK MI TTB9CIL DMLZDAK MN Prokineticin receptor-1 (PROKR1) DMLZDAK MT DTT DMLZDAK MA Inhibitor DMLZDAK RN Sulfonyl piperidine derivatives and their use for treating prokineticin mediated diseases. US10167273. DMLZDAK RU http://www.freepatentsonline.com/US10167273.html DMYCH0G DI DMYCH0G DMYCH0G DN ZINC584606052 DMYCH0G MI TT6A59G DMYCH0G MN Phosphodiesterase 4C (PDE4C) DMYCH0G MT DTT DMYCH0G MA Inhibitor DMYCH0G RN Imidazopyridazine compounds. US9598421. DMYCH0G RU http://www.freepatentsonline.com/US9598421.html DMW9P6U DI DMW9P6U DMW9P6U DN ZINC915379 DMW9P6U MI TTLKF5M DMW9P6U MN NAD-dependent deacetylase sirtuin-2 (SIRT2) DMW9P6U MT DTT DMW9P6U MA Inhibitor DMW9P6U RN Small molecule activators of NRF2 pathway. US9737525. DMW9P6U RU http://www.freepatentsonline.com/US9737525.html DMR0F4H DI DMR0F4H DMR0F4H DN ZINC959121 DMR0F4H MI TTU3WV6 DMR0F4H MN SRSF protein kinase 1 (SRPK1) DMR0F4H MT DTT DMR0F4H MA Inhibitor DMR0F4H RN Piperazine derivatives for treating disorders. US9695160. DMR0F4H RU http://www.freepatentsonline.com/US9695160.html DM3OPBR DI DM3OPBR DM3OPBR DN ZNFTXQFGUIKQQE-UHFFFAOYSA-N DM3OPBR MI TTDYP7I DM3OPBR MN Sphingosine-1-phosphate receptor 3 (S1PR3) DM3OPBR MT DTT DM3OPBR MA Inhibitor DM3OPBR RN 6-amino-pyrimidine-4-carboxamide derivatives and related compounds which bind to the sphingosine 1-phosphate (S1P) receptor for the treatment of multiple sclerosis. US9150519. DM3OPBR RU http://www.freepatentsonline.com/US9150519.html DMXYA5K DI DMXYA5K DMXYA5K DN Agomelatine DMXYA5K MI DEJGDUW DMXYA5K MN Cytochrome P450 1A2 (CYP1A2) DMXYA5K MT DME DMXYA5K MA Metabolism DMXYA5K RN Does celecoxib inhibit agomelatine metabolism via CYP2C9 or CYP1A2? Drug Des Devel Ther. 2018 Jul 11;12:2169-2172. DMXYA5K RU https://www.ncbi.nlm.nih.gov/pubmed/?term=30034221 DMXYA5K DI DMXYA5K DMXYA5K DN Agomelatine DMXYA5K MI TT0WAIE DMXYA5K MN Melatonin receptor type 1A (MTNR1A) DMXYA5K MT DTT DMXYA5K MA Agonist DMXYA5K RN Melatonin receptor agonists: SAR and applications to the treatment of sleep-wake disorders. Curr Top Med Chem. 2008;8(11):954-68. DMXYA5K RU https://pubmed.ncbi.nlm.nih.gov/18673165 DMYJ8Z3 DI DMYJ8Z3 DMYJ8Z3 DN Alprenolol DMYJ8Z3 MI TTR6W5O DMYJ8Z3 MN Adrenergic receptor beta-1 (ADRB1) DMYJ8Z3 MT DTT DMYJ8Z3 MA Antagonist DMYJ8Z3 RN Beta-blockers alprenolol and carvedilol stimulate beta-arrestin-mediated EGFR transactivation. Proc Natl Acad Sci U S A. 2008 Sep 23;105(38):14555-60. DMYJ8Z3 RU https://pubmed.ncbi.nlm.nih.gov/18787115 DMYJ8Z3 DI DMYJ8Z3 DMYJ8Z3 DN Alprenolol DMYJ8Z3 MI DECB0K3 DMYJ8Z3 MN Cytochrome P450 2D6 (CYP2D6) DMYJ8Z3 MT DME DMYJ8Z3 MA Metabolism DMYJ8Z3 RN Influence of the CYP2D6 isoenzyme in patients treated with venlafaxine for major depressive disorder: clinical and economic consequences. PLoS One. 2014 Nov 4;9(11):e90453. DMYJ8Z3 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=25369508 DMYJ8Z3 DI DMYJ8Z3 DMYJ8Z3 DN Alprenolol DMYJ8Z3 MI DTUGYRD DMYJ8Z3 MN P-glycoprotein 1 (ABCB1) DMYJ8Z3 MT DTP DMYJ8Z3 MA Substrate DMYJ8Z3 RN A novel screening strategy to identify ABCB1 substrates and inhibitors. Naunyn Schmiedebergs Arch Pharmacol. 2009 Jan;379(1):11-26. DMYJ8Z3 RU https://doi.org/10.1007/s00210-008-0345-0 DMGVNJ7 DI DMGVNJ7 DMGVNJ7 DN Amineptine DMGVNJ7 MI TTVBI8W DMGVNJ7 MN Dopamine transporter (DAT) DMGVNJ7 MT DTT DMGVNJ7 MA Inhibitor DMGVNJ7 RN Amineptine in the treatment of amphetamine withdrawal: a placebo-controlled, randomised, double-blind study. J Med Assoc Thai. 1997 Sep;80(9):587-92. DMGVNJ7 RU https://pubmed.ncbi.nlm.nih.gov/9347672 DMQ9RBV DI DMQ9RBV DMQ9RBV DN Aminopterin DMQ9RBV MI TT9SL3Q DMQ9RBV MN Polypeptide deformylase (PDF) DMQ9RBV MT DTT DMQ9RBV MA Inhibitor DMQ9RBV RN Loss of folylpoly-gamma-glutamate synthetase activity is a dominant mechanism of resistance to polyglutamylation-dependent novel antifolates in multiple human leukemia sublines. Int J Cancer. 2003 Feb 20;103(5):587-99. DMQ9RBV RU https://pubmed.ncbi.nlm.nih.gov/12494465 DM2HN6Q DI DM2HN6Q DM2HN6Q DN Astemizole DM2HN6Q MI DECB0K3 DM2HN6Q MN Cytochrome P450 2D6 (CYP2D6) DM2HN6Q MT DME DM2HN6Q MA Metabolism DM2HN6Q RN Involvement of multiple human cytochromes P450 in the liver microsomal metabolism of astemizole and a comparison with terfenadine. Br J Clin Pharmacol. 2001 Feb;51(2):133-42. DM2HN6Q RU https://www.ncbi.nlm.nih.gov/pubmed/?term=11259984 DM2HN6Q DI DM2HN6Q DM2HN6Q DN Astemizole DM2HN6Q MI DERSX5P DM2HN6Q MN Cytochrome P450 2J2 (CYP2J2) DM2HN6Q MT DME DM2HN6Q MA Metabolism DM2HN6Q RN Identifying a selective substrate and inhibitor pair for the evaluation of CYP2J2 activity. Drug Metab Dispos. 2012 May;40(5):943-51. DM2HN6Q RU https://www.ncbi.nlm.nih.gov/pubmed/?term=22328583 DM2HN6Q DI DM2HN6Q DM2HN6Q DN Astemizole DM2HN6Q MI DE4LYSA DM2HN6Q MN Cytochrome P450 3A4 (CYP3A4) DM2HN6Q MT DME DM2HN6Q MA Metabolism DM2HN6Q RN Summary of information on human CYP enzymes: human P450 metabolism data. Drug Metab Rev. 2002 Feb-May;34(1-2):83-448. DM2HN6Q RU https://www.ncbi.nlm.nih.gov/pubmed/?term=11996015 DM2HN6Q DI DM2HN6Q DM2HN6Q DN Astemizole DM2HN6Q MI DEIBDNY DM2HN6Q MN Cytochrome P450 3A5 (CYP3A5) DM2HN6Q MT DME DM2HN6Q MA Metabolism DM2HN6Q RN Drug Interactions Flockhart Table DM2HN6Q RU https://drug-interactions.medicine.iu.edu/Main-Table.aspx DM2HN6Q DI DM2HN6Q DM2HN6Q DN Astemizole DM2HN6Q MI DERD86B DM2HN6Q MN Cytochrome P450 3A7 (CYP3A7) DM2HN6Q MT DME DM2HN6Q MA Metabolism DM2HN6Q RN Drug Interactions Flockhart Table DM2HN6Q RU https://drug-interactions.medicine.iu.edu/Main-Table.aspx DM2HN6Q DI DM2HN6Q DM2HN6Q DN Astemizole DM2HN6Q MI TTTIBOJ DM2HN6Q MN Histamine H1 receptor (H1R) DM2HN6Q MT DTT DM2HN6Q MA Antagonist DM2HN6Q RN Histamine H1 receptor induces cytosolic calcium increase and aquaporin translocation in human salivary gland cells. J Pharmacol Exp Ther. 2009 Aug;330(2):403-12. DM2HN6Q RU https://pubmed.ncbi.nlm.nih.gov/19443731 DM2HN6Q DI DM2HN6Q DM2HN6Q DN Astemizole DM2HN6Q MI DTUGYRD DM2HN6Q MN P-glycoprotein 1 (ABCB1) DM2HN6Q MT DTP DM2HN6Q MA Substrate DM2HN6Q RN Improving the prediction of the brain disposition for orally administered drugs using BDDCS. Adv Drug Deliv Rev. 2012 Jan;64(1):95-109. DM2HN6Q RU https://doi.org/10.1016/j.addr.2011.12.008 DM0J92L DI DM0J92L DM0J92L DN Benactyzine DM0J92L MI TTH18TF DM0J92L MN Muscarinic acetylcholine receptor M5 (CHRM5) DM0J92L MT DTT DM0J92L MA Antagonist DM0J92L RN The muscarinic antagonists aprophen and benactyzine are noncompetitive inhibitors of the nicotinic acetylcholine receptor. Mol Pharmacol. 1987 Nov;32(5):678-85. DM0J92L RU https://pubmed.ncbi.nlm.nih.gov/3683366 DM5ZOX8 DI DM5ZOX8 DM5ZOX8 DN Benoxaprofen DM5ZOX8 MI TTK3C21 DM5ZOX8 MN Acetoacetyl-CoA thiolase (ACAT1) DM5ZOX8 MT DTT DM5ZOX8 MA Inhibitor DM5ZOX8 RN Inhibition of lyso-PAF: acetyl-CoA acetyltransferase by salicylates and other compounds. Prostaglandins. 1988 Jun;35(6):939-44. DM5ZOX8 RU https://pubmed.ncbi.nlm.nih.gov/2903520 DMJMHNL DI DMJMHNL DMJMHNL DN Bethanidine DMJMHNL MI TTR6W5O DMJMHNL MN Adrenergic receptor beta-1 (ADRB1) DMJMHNL MT DTT DMJMHNL MA Antagonist DMJMHNL RN Withdrawal syndromes and the cessation of antihypertensive therapy. Arch Intern Med. 1981 Aug;141(9):1125-7. DMJMHNL RU https://pubmed.ncbi.nlm.nih.gov/6114720 DMPJKRL DI DMPJKRL DMPJKRL DN Bithionol DMPJKRL MI TTG5QB7 DMPJKRL MN Calpain-2 (CAPN2) DMPJKRL MT DTT DMPJKRL MA Inhibitor DMPJKRL RN In silico identification and biochemical evaluation of novel inhibitors of NRH:quinone oxidoreductase 2 (NQO2). Bioorg Med Chem Lett. 2010 Dec 15;20(24):7331-6. DMPJKRL RU https://pubmed.ncbi.nlm.nih.gov/21074425 DMPJKRL DI DMPJKRL DMPJKRL DN Bithionol DMPJKRL MI TTZAYWL DMPJKRL MN Estrogen receptor (ESR) DMPJKRL MT DTT DMPJKRL MA Inhibitor DMPJKRL RN In silico identification and biochemical evaluation of novel inhibitors of NRH:quinone oxidoreductase 2 (NQO2). Bioorg Med Chem Lett. 2010 Dec 15;20(24):7331-6. DMPJKRL RU https://pubmed.ncbi.nlm.nih.gov/21074425 DMPJKRL DI DMPJKRL DMPJKRL DN Bithionol DMPJKRL MI TTOM3J0 DMPJKRL MN Estrogen receptor beta (ESR2) DMPJKRL MT DTT DMPJKRL MA Inhibitor DMPJKRL RN In silico identification and biochemical evaluation of novel inhibitors of NRH:quinone oxidoreductase 2 (NQO2). Bioorg Med Chem Lett. 2010 Dec 15;20(24):7331-6. DMPJKRL RU https://pubmed.ncbi.nlm.nih.gov/21074425 DMPJKRL DI DMPJKRL DMPJKRL DN Bithionol DMPJKRL MI TTL53M6 DMPJKRL MN Induced myeloid leukemia cell differentiation protein Mcl-1 (MCL1) DMPJKRL MT DTT DMPJKRL MA Inhibitor DMPJKRL RN In silico identification and biochemical evaluation of novel inhibitors of NRH:quinone oxidoreductase 2 (NQO2). Bioorg Med Chem Lett. 2010 Dec 15;20(24):7331-6. DMPJKRL RU https://pubmed.ncbi.nlm.nih.gov/21074425 DMBQYO0 DI DMBQYO0 DMBQYO0 DN Casopitant DMBQYO0 MI TTZPO1L DMBQYO0 MN Substance-P receptor (TACR1) DMBQYO0 MT DTT DMBQYO0 MA Antagonist DMBQYO0 RN Novel drugs and therapeutic targets for severe mood disorders. Neuropsychopharmacology. 2008 Aug;33(9):2080-92. DMBQYO0 RU https://pubmed.ncbi.nlm.nih.gov/18172433 DM4Y95F DI DM4Y95F DM4Y95F DN Cephaloridine DM4Y95F MI DET9I1W DM4Y95F MN Beta-lactamase (blaB) DM4Y95F MT DME DM4Y95F MA Metabolism DM4Y95F RN Purification and characterization of a new beta-lactamase from Bacteroides uniformis. Antimicrob Agents Chemother. 1995 Jul;39(7):1458-61. DM4Y95F RU https://pubmed.ncbi.nlm.nih.gov/7492085 DM4Y95F DI DM4Y95F DM4Y95F DN Cephaloridine DM4Y95F MI DEKGVS4 DM4Y95F MN Beta-lactamase (blaB) DM4Y95F MT DME DM4Y95F MA Metabolism DM4Y95F RN Characterization of the penA and penR genes of Burkholderia cepacia 249 which encode the chromosomal class A penicillinase and its LysR-type transcriptional regulator. Antimicrob Agents Chemother. 1997 Nov;41(11):2399-405. DM4Y95F RU https://pubmed.ncbi.nlm.nih.gov/9371340 DM4Y95F DI DM4Y95F DM4Y95F DN Cephaloridine DM4Y95F MI DES5XRU DM4Y95F MN Cytochrome P450 2C8 (CYP2C8) DM4Y95F MT DME DM4Y95F MA Metabolism DM4Y95F RN Gemfibrozil and its glucuronide inhibit the organic anion transporting polypeptide 2 (OATP2/OATP1B1:SLC21A6)-mediated hepatic uptake and CYP2C8-mediated metabolism of cerivastatin: analysis of the mechanism of the clinically relevant drug-drug interaction between cerivastatin and gemfibrozil. J Pharmacol Exp Ther. 2004 Oct;311(1):228-36. DM4Y95F RU https://www.ncbi.nlm.nih.gov/pubmed/?term=15194707 DM4Y95F DI DM4Y95F DM4Y95F DN Cephaloridine DM4Y95F MI DTVP67E DM4Y95F MN Organic anion transporter 3 (SLC22A8) DM4Y95F MT DTP DM4Y95F MA Substrate DM4Y95F RN Human organic anion transporter hOAT3 is a potent transporter of cephalosporin antibiotics, in comparison with hOAT1. Biochem Pharmacol. 2005 Oct 1;70(7):1104-13. DM4Y95F RU http://www.ncbi.nlm.nih.gov/pubmed/16098483 DM4Y95F DI DM4Y95F DM4Y95F DN Cephaloridine DM4Y95F MI DT9G7XN DM4Y95F MN Peptide transporter 1 (SLC15A1) DM4Y95F MT DTP DM4Y95F MA Substrate DM4Y95F RN Intestinal transport of beta-lactam antibiotics: analysis of the affinity at the H+/peptide symporter (PEPT1), the uptake into Caco-2 cell monolayers and the transepithelial flux. Pharm Res. 1999 Jan;16(1):55-61. DM4Y95F RU https://doi.org/10.1023/A:1018814627484 DMSV2WZ DI DMSV2WZ DMSV2WZ DN Chlorotrianisene DMSV2WZ MI TTZAYWL DMSV2WZ MN Estrogen receptor (ESR) DMSV2WZ MT DTT DMSV2WZ MA Binder DMSV2WZ RN Inactivation of the uterine estrogen receptor binding of estradiol during P-450 catalyzed metabolism of chlorotrianisene (TACE). Speculation that TACE antiestrogenic activity involves covalent binding to the estrogen receptor. FEBS Lett. 1990 Feb 12;261(1):59-62. DMSV2WZ RU https://pubmed.ncbi.nlm.nih.gov/2307235 DM746BZ DI DM746BZ DM746BZ DN Clioquinol DM746BZ MI TTUNARX DM746BZ MN Carbonic anhydrase (CA) DM746BZ MT DTT DM746BZ MA Inhibitor DM746BZ RN Carbonic anhydrase inhibitors: Inhibition of the new membrane-associated isoform XV with phenols. Bioorg Med Chem Lett. 2008 Jun 15;18(12):3593-6. DM746BZ RU https://pubmed.ncbi.nlm.nih.gov/18501600 DM746BZ DI DM746BZ DM746BZ DN Clioquinol DM746BZ MI TTQW87Y DM746BZ MN Opioid receptor kappa (OPRK1) DM746BZ MT DTT DM746BZ MA Inhibitor DM746BZ RN In silico identification and biochemical evaluation of novel inhibitors of NRH:quinone oxidoreductase 2 (NQO2). Bioorg Med Chem Lett. 2010 Dec 15;20(24):7331-6. DM746BZ RU https://pubmed.ncbi.nlm.nih.gov/21074425 DM746BZ DI DM746BZ DM746BZ DN Clioquinol DM746BZ MI DEYWLRK DM746BZ MN Sulfotransferase 1A1 (SULT1A1) DM746BZ MT DME DM746BZ MA Metabolism DM746BZ RN Clioquinol is sulfated by human jejunum cytosol and SULT1A3, a human-specific dopamine sulfotransferase. Toxicol Lett. 2011 Oct 10;206(2):229-33. DM746BZ RU https://www.ncbi.nlm.nih.gov/pubmed/?term=21820498 DMJ7YDS DI DMJ7YDS DMJ7YDS DN Dexfenfluramine DMJ7YDS MI DEJGDUW DMJ7YDS MN Cytochrome P450 1A2 (CYP1A2) DMJ7YDS MT DME DMJ7YDS MA Metabolism DMJ7YDS RN Appetite suppressant drugs as inhibitors of human cytochromes P450: in vitro inhibition of P450-2D6 by D- and L-fenfluramine, but not phentermine. J Clin Psychopharmacol. 1998 Aug;18(4):338-41. DMJ7YDS RU https://www.ncbi.nlm.nih.gov/pubmed/?term=9690701 DMJ7YDS DI DMJ7YDS DMJ7YDS DN Dexfenfluramine DMJ7YDS MI DECB0K3 DMJ7YDS MN Cytochrome P450 2D6 (CYP2D6) DMJ7YDS MT DME DMJ7YDS MA Metabolism DMJ7YDS RN Metabolism of dexfenfluramine in human liver microsomes and by recombinant enzymes: role of CYP2D6 and 1A2. Pharmacogenetics. 1998 Oct;8(5):423-32. DMJ7YDS RU https://www.ncbi.nlm.nih.gov/pubmed/?term=9825834 DMJ7YDS DI DMJ7YDS DMJ7YDS DN Dexfenfluramine DMJ7YDS MI TT3ROYC DMJ7YDS MN Serotonin transporter (SERT) DMJ7YDS MT DTT DMJ7YDS MA Inhibitor DMJ7YDS RN Serotonergic drugs : effects on appetite expression and use for the treatment of obesity. Drugs. 2007;67(1):27-55. DMJ7YDS RU https://pubmed.ncbi.nlm.nih.gov/17209663 DMRZ5D7 DI DMRZ5D7 DMRZ5D7 DN Droxicam DMRZ5D7 MI TTK0943 DMRZ5D7 MN Prostaglandin G/H synthase (COX) DMRZ5D7 MT DTT DMRZ5D7 MA Modulator DMRZ5D7 RN Pharmacokinetic profile of droxicam. Eur J Rheumatol Inflamm. 1991;11(4):10-4. DMRZ5D7 RU https://pubmed.ncbi.nlm.nih.gov/1365484 DMV5KR3 DI DMV5KR3 DMV5KR3 DN Ebrotidine DMV5KR3 MI TTQHJ1K DMV5KR3 MN Histamine H2 receptor (H2R) DMV5KR3 MT DTT DMV5KR3 MA Modulator DMV5KR3 RN Histamine H2-receptor antagonist action of ebrotidine. Effects on gastric acid secretion, gastrin levels and NSAID-induced gastrotoxicity in the rat. Arzneimittelforschung. 1997 Apr;47(4A):439-46. DMV5KR3 RU https://pubmed.ncbi.nlm.nih.gov/9205740 DMK0GHV DI DMK0GHV DMK0GHV DN Encainide DMK0GHV MI DECB0K3 DMK0GHV MN Cytochrome P450 2D6 (CYP2D6) DMK0GHV MT DME DMK0GHV MA Metabolism DMK0GHV RN Effects of the antifungal agents on oxidative drug metabolism: clinical relevance. Clin Pharmacokinet. 2000 Feb;38(2):111-80. DMK0GHV RU https://www.ncbi.nlm.nih.gov/pubmed/?term=10709776 DMK0GHV DI DMK0GHV DMK0GHV DN Encainide DMK0GHV MI TTZOVE0 DMK0GHV MN Voltage-gated sodium channel alpha Nav1.5 (SCN5A) DMK0GHV MT DTT DMK0GHV MA Blocker DMK0GHV RN From first class to third class: recent upheaval in antiarrhythmic therapy--lessons from clinical trials. Am J Cardiol. 1996 Aug 29;78(4A):28-33. DMK0GHV RU https://pubmed.ncbi.nlm.nih.gov/8780326 DM67PWD DI DM67PWD DM67PWD DN Etilefrine DM67PWD MI TTVIREA DM67PWD MN Adrenergic receptor (ADR) DM67PWD MT DTT DM67PWD MA Modulator DM67PWD RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015 DM67PWD RU https://www.accessdata.fda.gov/scripts/cder/drugsatfda/ DM67PWD DI DM67PWD DM67PWD DN Etilefrine DM67PWD MI DT6201N DM67PWD MN Organic cation transporter 3 (SLC22A3) DM67PWD MT DTP DM67PWD MA Substrate DM67PWD RN Drug specificity and intestinal membrane localization of human organic cation transporters (OCT). Biochem Pharmacol. 2005 Dec 5;70(12):1851-60. DM67PWD RU http://www.ncbi.nlm.nih.gov/pubmed/16263091 DMVG9YN DI DMVG9YN DMVG9YN DN Fencamfamine DMVG9YN MI TTEX248 DMVG9YN MN Dopamine D2 receptor (D2R) DMVG9YN MT DTT DMVG9YN MA Agonist DMVG9YN RN Dopamine uptake inhibiting versus dopamine releasing properties of fencamfamine: an in vitro study. Biochem Pharmacol. 1983 Aug 1;32(15):2329-31. DMVG9YN RU https://pubmed.ncbi.nlm.nih.gov/6136281 DMH6NG5 DI DMH6NG5 DMH6NG5 DN Fendiline DMH6NG5 MI TT0K1SC DMH6NG5 MN 5-HT 2B receptor (HTR2B) DMH6NG5 MT DTT DMH6NG5 MA Inhibitor DMH6NG5 RN Development, validation, and use of quantitative structure-activity relationship models of 5-hydroxytryptamine (2B) receptor ligands to identify no... J Med Chem. 2010 Nov 11;53(21):7573-86. DMH6NG5 RU https://pubmed.ncbi.nlm.nih.gov/20958049 DMH6NG5 DI DMH6NG5 DMH6NG5 DN Fendiline DMH6NG5 MI DE4LYSA DMH6NG5 MN Cytochrome P450 3A4 (CYP3A4) DMH6NG5 MT DME DMH6NG5 MA Metabolism DMH6NG5 RN Integrated analysis on the physicochemical properties of dihydropyridine calcium channel blockers in grapefruit juice interactions. Curr Pharm Biotechnol. 2012 Jul;13(9):1705-17. DMH6NG5 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=22039822 DMY9P37 DI DMY9P37 DMY9P37 DN Flupenthixol DMY9P37 MI TTEX248 DMY9P37 MN Dopamine D2 receptor (D2R) DMY9P37 MT DTT DMY9P37 MA Antagonist DMY9P37 RN A role for medial prefrontal dopaminergic innervation in instrumental conditioning. J Neurosci. 2009 May 20;29(20):6599-606. DMY9P37 RU https://pubmed.ncbi.nlm.nih.gov/19458230 DMWIDJK DI DMWIDJK DMWIDJK DN FORMESTANE DMWIDJK MI TTSZLWK DMWIDJK MN Aromatase (CYP19A1) DMWIDJK MT DTT DMWIDJK MA Inhibitor DMWIDJK RN The taiwaniaquinoids: a review. J Nat Prod. 2010 Feb 26;73(2):284-98. DMWIDJK RU https://pubmed.ncbi.nlm.nih.gov/20102168 DM9AGWQ DI DM9AGWQ DM9AGWQ DN HEXESTROL DM9AGWQ MI TTZAYWL DM9AGWQ MN Estrogen receptor (ESR) DM9AGWQ MT DTT DM9AGWQ MA Inhibitor DM9AGWQ RN Bone targeted drugs 2. synthesis of estrogens with hydroxyapatite affinity, Bioorg. Med. Chem. Lett. 6(9):1047-1050 (1996). DM9AGWQ RU http://www.sciencedirect.com/science/article/pii/0960894X96001655 DM9AGWQ DI DM9AGWQ DM9AGWQ DN HEXESTROL DM9AGWQ MI TTOM3J0 DM9AGWQ MN Estrogen receptor beta (ESR2) DM9AGWQ MT DTT DM9AGWQ MA Inhibitor DM9AGWQ RN Bone targeted drugs 2. synthesis of estrogens with hydroxyapatite affinity, Bioorg. Med. Chem. Lett. 6(9):1047-1050 (1996). DM9AGWQ RU http://www.sciencedirect.com/science/article/pii/0960894X96001655 DMSO2T9 DI DMSO2T9 DMSO2T9 DN Ibuproxam DMSO2T9 MI TT2J34L DMSO2T9 MN Arachidonate 5-lipoxygenase (5-LOX) DMSO2T9 MT DTT DMSO2T9 MA Inhibitor DMSO2T9 RN In vivo characterization of hydroxamic acid inhibitors of 5-lipoxygenase. J Med Chem. 1987 Nov;30(11):2121-6. DMSO2T9 RU https://pubmed.ncbi.nlm.nih.gov/3669019 DM5QSKN DI DM5QSKN DM5QSKN DN INDOPROFEN DM5QSKN MI TTMWT8Z DM5QSKN MN C-X-C chemokine receptor type 1 (CXCR1) DM5QSKN MT DTT DM5QSKN MA Inhibitor DM5QSKN RN 2-Arylpropionic CXC chemokine receptor 1 (CXCR1) ligands as novel noncompetitive CXCL8 inhibitors. J Med Chem. 2005 Jun 30;48(13):4312-31. DM5QSKN RU https://pubmed.ncbi.nlm.nih.gov/15974585 DM5QSKN DI DM5QSKN DM5QSKN DN INDOPROFEN DM5QSKN MI TT30C9G DM5QSKN MN C-X-C chemokine receptor type 2 (CXCR2) DM5QSKN MT DTT DM5QSKN MA Inhibitor DM5QSKN RN 2-Arylpropionic CXC chemokine receptor 1 (CXCR1) ligands as novel noncompetitive CXCL8 inhibitors. J Med Chem. 2005 Jun 30;48(13):4312-31. DM5QSKN RU https://pubmed.ncbi.nlm.nih.gov/15974585 DM5QSKN DI DM5QSKN DM5QSKN DN INDOPROFEN DM5QSKN MI TTIV96N DM5QSKN MN Fatty acid-binding protein 1 (FABP1) DM5QSKN MT DTT DM5QSKN MA Inhibitor DM5QSKN RN Characterization of the drug binding specificity of rat liver fatty acid binding protein. J Med Chem. 2008 Jul 10;51(13):3755-64. DM5QSKN RU https://pubmed.ncbi.nlm.nih.gov/18533710 DM5QSKN DI DM5QSKN DM5QSKN DN INDOPROFEN DM5QSKN MI TT8NGED DM5QSKN MN Prostaglandin G/H synthase 1 (COX-1) DM5QSKN MT DTT DM5QSKN MA Inhibitor DM5QSKN RN 2-Arylpropionic CXC chemokine receptor 1 (CXCR1) ligands as novel noncompetitive CXCL8 inhibitors. J Med Chem. 2005 Jun 30;48(13):4312-31. DM5QSKN RU https://pubmed.ncbi.nlm.nih.gov/15974585 DM5QSKN DI DM5QSKN DM5QSKN DN INDOPROFEN DM5QSKN MI TTVKILB DM5QSKN MN Prostaglandin G/H synthase 2 (COX-2) DM5QSKN MT DTT DM5QSKN MA Inhibitor DM5QSKN RN 2-Arylpropionic CXC chemokine receptor 1 (CXCR1) ligands as novel noncompetitive CXCL8 inhibitors. J Med Chem. 2005 Jun 30;48(13):4312-31. DM5QSKN RU https://pubmed.ncbi.nlm.nih.gov/15974585 DMNSJFD DI DMNSJFD DMNSJFD DN Indoramin DMNSJFD MI TT34BHT DMNSJFD MN Adrenergic receptor alpha-1D (ADRA1D) DMNSJFD MT DTT DMNSJFD MA Inhibitor DMNSJFD RN Alpha- and beta-adrenoceptors: from the gene to the clinic. 1. Molecular biology and adrenoceptor subclassification. J Med Chem. 1995 Sep 1;38(18):3415-44. DMNSJFD RU https://pubmed.ncbi.nlm.nih.gov/7658428 DMNSJFD DI DMNSJFD DMNSJFD DN Indoramin DMNSJFD MI TTWM4TY DMNSJFD MN Adrenergic receptor alpha-2B (ADRA2B) DMNSJFD MT DTT DMNSJFD MA Inhibitor DMNSJFD RN Alpha- and beta-adrenoceptors: from the gene to the clinic. 1. Molecular biology and adrenoceptor subclassification. J Med Chem. 1995 Sep 1;38(18):3415-44. DMNSJFD RU https://pubmed.ncbi.nlm.nih.gov/7658428 DMNSJFD DI DMNSJFD DMNSJFD DN Indoramin DMNSJFD MI TT2NUT5 DMNSJFD MN Adrenergic receptor alpha-2C (ADRA2C) DMNSJFD MT DTT DMNSJFD MA Inhibitor DMNSJFD RN Alpha- and beta-adrenoceptors: from the gene to the clinic. 1. Molecular biology and adrenoceptor subclassification. J Med Chem. 1995 Sep 1;38(18):3415-44. DMNSJFD RU https://pubmed.ncbi.nlm.nih.gov/7658428 DMNSJFD DI DMNSJFD DMNSJFD DN Indoramin DMNSJFD MI DECB0K3 DMNSJFD MN Cytochrome P450 2D6 (CYP2D6) DMNSJFD MT DME DMNSJFD MA Metabolism DMNSJFD RN Summary of information on human CYP enzymes: human P450 metabolism data. Drug Metab Rev. 2002 Feb-May;34(1-2):83-448. DMNSJFD RU https://www.ncbi.nlm.nih.gov/pubmed/?term=11996015 DMGTBC7 DI DMGTBC7 DMGTBC7 DN ISIS 2922 DMGTBC7 MI TTS92NQ DMGTBC7 MN Cytomegalovirus DNA polymerase messenger RNA (CMV DNA polymerase mRNA) DMGTBC7 MT DTT DMGTBC7 RN US patent application no. 5,442,049, Oligonucleotides for modulating the effects of cytomegalovirus infections. DMGTBC7 RU http://www.patentbuddy.com/Patent/5442049?ft=true&sr=true DMMS2J5 DI DMMS2J5 DMMS2J5 DN Isoxicam DMMS2J5 MI DTUGYRD DMMS2J5 MN P-glycoprotein 1 (ABCB1) DMMS2J5 MT DTP DMMS2J5 MA Substrate DMMS2J5 RN Human intestinal transporter database: QSAR modeling and virtual profiling of drug uptake, efflux and interactions. Pharm Res. 2013 Apr;30(4):996-1007. DMMS2J5 RU https://doi.org/10.1007/s11095-012-0935-x DMACMLO DI DMACMLO DMACMLO DN LYSERGIC ACID DIETHYLAMIDE DMACMLO MI TTSQIFT DMACMLO MN 5-HT 1A receptor (HTR1A) DMACMLO MT DTT DMACMLO MA Inhibitor DMACMLO RN Stereoselective LSD-like activity in a series of d-lysergic acid amides of (R)- and (S)-2-aminoalkanes. J Med Chem. 1995 Mar 17;38(6):958-66. DMACMLO RU https://pubmed.ncbi.nlm.nih.gov/7699712 DMACMLO DI DMACMLO DMACMLO DN LYSERGIC ACID DIETHYLAMIDE DMACMLO MI TTJQOD7 DMACMLO MN 5-HT 2A receptor (HTR2A) DMACMLO MT DTT DMACMLO MA Inhibitor DMACMLO RN C-(4,5,6-trimethoxyindan-1-yl)methanamine: a mescaline analogue designed using a homology model of the 5-HT2A receptor. J Med Chem. 2006 Jul 13;49(14):4269-74. DMACMLO RU https://pubmed.ncbi.nlm.nih.gov/16821786 DM79GRO DI DM79GRO DM79GRO DN Metamizole DM79GRO MI TT8NGED DM79GRO MN Prostaglandin G/H synthase 1 (COX-1) DM79GRO MT DTT DM79GRO MA Inhibitor DM79GRO RN Mechanisms of action of paracetamol and related analgesics. Inflammopharmacology. 2003;11(4):401-13. DM79GRO RU https://pubmed.ncbi.nlm.nih.gov/15035793 DM79GRO DI DM79GRO DM79GRO DN Metamizole DM79GRO MI DEZV4AP DM79GRO MN RNA cytidine acetyltransferase (hALP) DM79GRO MT DME DM79GRO MA Metabolism DM79GRO RN N-acetyltransferase 2 polymorphisms and susceptibility to infant leukemia with maternal exposure to dipyrone during pregnancy. Cancer Epidemiol Biomarkers Prev. 2010 Dec;19(12):3037-43. DM79GRO RU https://www.ncbi.nlm.nih.gov/pubmed/?term=20884738 DMW9NY0 DI DMW9NY0 DMW9NY0 DN Methaqualone DMW9NY0 MI DE4LYSA DMW9NY0 MN Cytochrome P450 3A4 (CYP3A4) DMW9NY0 MT DME DMW9NY0 MA Metabolism DMW9NY0 RN Assessment of the stereoselective metabolism of methaqualone in man by capillary electrophoresis. Electrophoresis. 2003 Aug;24(15):2598-607. DMW9NY0 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=12900872 DMCP2TS DI DMCP2TS DMCP2TS DN Nomifensine DMCP2TS MI TTEX248 DMCP2TS MN Dopamine D2 receptor (D2R) DMCP2TS MT DTT DMCP2TS MA Antagonist DMCP2TS RN Pharmacologically induced, subsecond dopamine transients in the caudate-putamen of the anesthetized rat. Synapse. 2007 Jan;61(1):37-9. DMCP2TS RU https://pubmed.ncbi.nlm.nih.gov/17068772 DMDKXYC DI DMDKXYC DMDKXYC DN Parabis DMDKXYC MI DTI7UX6 DMDKXYC MN Breast cancer resistance protein (ABCG2) DMDKXYC MT DTP DMDKXYC MA Substrate DMDKXYC RN Human and rat ABC transporter efflux of bisphenol a and bisphenol a glucuronide: interspecies comparison and implications for pharmacokinetic assessment. Toxicol Sci. 2012 Aug;128(2):317-25. DMDKXYC RU https://doi.org/10.1093/toxsci/kfs167 DMRQAM0 DI DMRQAM0 DMRQAM0 DN Phenacetin DMRQAM0 MI DEKP5HX DMRQAM0 MN Cholesterol 24-hydroxylase (CYP46A1) DMRQAM0 MT DME DMRQAM0 MA Metabolism DMRQAM0 RN Broad substrate specificity of human cytochrome P450 46A1 which initiates cholesterol degradation in the brain. Biochemistry. 2003 Dec 9;42(48):14284-92. DMRQAM0 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=14640697 DMRQAM0 DI DMRQAM0 DMRQAM0 DN Phenacetin DMRQAM0 MI DE6OQ3W DMRQAM0 MN Cytochrome P450 1A1 (CYP1A1) DMRQAM0 MT DME DMRQAM0 MA Metabolism DMRQAM0 RN Identification of CYP3A4 as the enzyme involved in the mono-N-dealkylation of disopyramide enantiomers in humans. Drug Metab Dispos. 2000 Aug;28(8):937-44. DMRQAM0 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=10901704 DMRQAM0 DI DMRQAM0 DMRQAM0 DN Phenacetin DMRQAM0 MI DEJGDUW DMRQAM0 MN Cytochrome P450 1A2 (CYP1A2) DMRQAM0 MT DME DMRQAM0 MA Metabolism DMRQAM0 RN CYP2A13 metabolizes the substrates of human CYP1A2, phenacetin, and theophylline. Drug Metab Dispos. 2007 Mar;35(3):335-9. DMRQAM0 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=17178771 DMRQAM0 DI DMRQAM0 DMRQAM0 DN Phenacetin DMRQAM0 MI DEXZA9U DMRQAM0 MN Cytochrome P450 2A13 (CYP2A13) DMRQAM0 MT DME DMRQAM0 MA Metabolism DMRQAM0 RN CYP2A13 metabolizes the substrates of human CYP1A2, phenacetin, and theophylline. Drug Metab Dispos. 2007 Mar;35(3):335-9. DMRQAM0 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=17178771 DMRQAM0 DI DMRQAM0 DMRQAM0 DN Phenacetin DMRQAM0 MI DEJVYAZ DMRQAM0 MN Cytochrome P450 2A6 (CYP2A6) DMRQAM0 MT DME DMRQAM0 MA Metabolism DMRQAM0 RN Activation of phenacetin O-deethylase activity by alpha-naphthoflavone in human liver microsomes. Xenobiotica. 1999 Sep;29(9):885-98. DMRQAM0 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=10548449 DMRQAM0 DI DMRQAM0 DMRQAM0 DN Phenacetin DMRQAM0 MI DE5IED8 DMRQAM0 MN Cytochrome P450 2C9 (CYP2C9) DMRQAM0 MT DME DMRQAM0 MA Metabolism DMRQAM0 RN Activation of phenacetin O-deethylase activity by alpha-naphthoflavone in human liver microsomes. Xenobiotica. 1999 Sep;29(9):885-98. DMRQAM0 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=10548449 DMRQAM0 DI DMRQAM0 DMRQAM0 DN Phenacetin DMRQAM0 MI DECB0K3 DMRQAM0 MN Cytochrome P450 2D6 (CYP2D6) DMRQAM0 MT DME DMRQAM0 MA Metabolism DMRQAM0 RN Human cytochromes P450 mediating phenacetin O-deethylation in vitro: validation of the high affinity component as an index of CYP1A2 activity. J Pharm Sci. 1998 Dec;87(12):1502-7. DMRQAM0 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=10189256 DMRQAM0 DI DMRQAM0 DMRQAM0 DN Phenacetin DMRQAM0 MI DEVDYN7 DMRQAM0 MN Cytochrome P450 2E1 (CYP2E1) DMRQAM0 MT DME DMRQAM0 MA Metabolism DMRQAM0 RN Involvement of CYP2E1 as A low-affinity enzyme in phenacetin O-deethylation in human liver microsomes. Drug Metab Dispos. 1999 Aug;27(8):860-5. DMRQAM0 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=10421611 DMRQAM0 DI DMRQAM0 DMRQAM0 DN Phenacetin DMRQAM0 MI DE4LYSA DMRQAM0 MN Cytochrome P450 3A4 (CYP3A4) DMRQAM0 MT DME DMRQAM0 MA Metabolism DMRQAM0 RN Involvement of CYP2E1 as A low-affinity enzyme in phenacetin O-deethylation in human liver microsomes. Drug Metab Dispos. 1999 Aug;27(8):860-5. DMRQAM0 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=10421611 DMRQAM0 DI DMRQAM0 DMRQAM0 DN Phenacetin DMRQAM0 MI TTL7C8Q DMRQAM0 MN Inosine-5'-monophosphate dehydrogenase 1 (IMPDH1) DMRQAM0 MT DTT DMRQAM0 MA Inhibitor DMRQAM0 RN A potent "fat base" nucleotide inhibitor of IMP dehydrogenase. Biochemistry. 1998 Aug 25;37(34):11949-52. DMRQAM0 RU https://pubmed.ncbi.nlm.nih.gov/9718319 DMRQAM0 DI DMRQAM0 DMRQAM0 DN Phenacetin DMRQAM0 MI DEGTFWK DMRQAM0 MN Mephenytoin 4-hydroxylase (CYP2C19) DMRQAM0 MT DME DMRQAM0 MA Metabolism DMRQAM0 RN Activation of phenacetin O-deethylase activity by alpha-naphthoflavone in human liver microsomes. Xenobiotica. 1999 Sep;29(9):885-98. DMRQAM0 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=10548449 DMRQAM0 DI DMRQAM0 DMRQAM0 DN Phenacetin DMRQAM0 MI TT8NGED DMRQAM0 MN Prostaglandin G/H synthase 1 (COX-1) DMRQAM0 MT DTT DMRQAM0 MA Inhibitor DMRQAM0 RN Direct toxicity of nonsteroidal antiinflammatory drugs for renal medullary cells. Proc Natl Acad Sci U S A. 2001 Apr 24;98(9):5317-22. DMRQAM0 RU https://pubmed.ncbi.nlm.nih.gov/11320259 DMQ52JG DI DMQ52JG DMQ52JG DN Phenformin DMQ52JG MI TTLAFZV DMQ52JG MN AMP-activated protein kinase (AMPK) DMQ52JG MT DTT DMQ52JG MA Activator DMQ52JG RN Complementary regulation of TBC1D1 and AS160 by growth factors, insulin and AMPK activators. Biochem J. 2008 Jan 15;409(2):449-59. DMQ52JG RU https://pubmed.ncbi.nlm.nih.gov/17995453 DMQ52JG DI DMQ52JG DMQ52JG DN Phenformin DMQ52JG MI DECB0K3 DMQ52JG MN Cytochrome P450 2D6 (CYP2D6) DMQ52JG MT DME DMQ52JG MA Metabolism DMQ52JG RN Neuronal cytochrome P450IID1 (debrisoquine/sparteine-type): potent inhibition of activity by (-)-cocaine and nucleotide sequence identity to human hepatic P450 gene CYP2D6. Mol Pharmacol. 1991 Jul;40(1):63-8. DMQ52JG RU https://www.ncbi.nlm.nih.gov/pubmed/?term=1857341 DMQ52JG DI DMQ52JG DMQ52JG DN Phenformin DMQ52JG MI DTT79CX DMQ52JG MN Organic cation transporter 1 (SLC22A1) DMQ52JG MT DTP DMQ52JG MA Substrate DMQ52JG RN Identification of novel substrates and structure-activity relationship of cellular uptake mediated by human organic cation transporters 1 and 2. J Med Chem. 2013 Sep 26;56(18):7232-42. DMQ52JG RU http://www.ncbi.nlm.nih.gov/pubmed/23984907 DM5SICT DI DM5SICT DM5SICT DN Phenolphthalein DM5SICT MI DTFI42L DM5SICT MN Multidrug resistance-associated protein 2 (ABCC2) DM5SICT MT DTP DM5SICT MA Substrate DM5SICT RN Biliary excretion of phenolphthalein sulfate in rats. Pharmacology. 2003 Aug;68(4):177-82. DM5SICT RU http://www.ncbi.nlm.nih.gov/pubmed/12837971 DM5SICT DI DM5SICT DM5SICT DN Phenolphthalein DM5SICT MI DEYGVN4 DM5SICT MN UDP-glucuronosyltransferase 1A1 (UGT1A1) DM5SICT MT DME DM5SICT MA Metabolism DM5SICT RN Inhibition of UDP-glucuronyltransferase activity in rat liver microsomes by pyrimidine derivatives. Comp Biochem Physiol C Pharmacol Toxicol Endocrinol. 1995 Nov;112(3):321-5. DM5SICT RU https://www.ncbi.nlm.nih.gov/pubmed/?term=8838685 DMTFK3O DI DMTFK3O DMTFK3O DN Phenylpropanolamine DMTFK3O MI TTG28O6 DMTFK3O MN Adrenergic receptor Alpha-1 (ADRA1) DMTFK3O MT DTT DMTFK3O MA Agonist DMTFK3O RN Synthesis and structure-activity studies on N-[5-(1H-imidazol-4-yl)-5,6,7,8-tetrahydro-1-naphthalenyl]methanesulfonamide, an imidazole-containing alpha(1A)-adrenoceptor agonist. J Med Chem. 2004 Jun 3;47(12):3220-35. DMTFK3O RU https://pubmed.ncbi.nlm.nih.gov/15163201 DMGQF3R DI DMGQF3R DMGQF3R DN Remoxipride DMGQF3R MI DECB0K3 DMGQF3R MN Cytochrome P450 2D6 (CYP2D6) DMGQF3R MT DME DMGQF3R MA Metabolism DMGQF3R RN Summary of information on human CYP enzymes: human P450 metabolism data. Drug Metab Rev. 2002 Feb-May;34(1-2):83-448. DMGQF3R RU https://www.ncbi.nlm.nih.gov/pubmed/?term=11996015 DMGQF3R DI DMGQF3R DMGQF3R DN Remoxipride DMGQF3R MI TTEX248 DMGQF3R MN Dopamine D2 receptor (D2R) DMGQF3R MT DTT DMGQF3R MA Antagonist DMGQF3R RN Atypical antipsychotics: mechanism of action. Can J Psychiatry. 2002 Feb;47(1):27-38. DMGQF3R RU https://pubmed.ncbi.nlm.nih.gov/11873706 DMVMIK2 DI DMVMIK2 DMVMIK2 DN Roxithromycin DMVMIK2 MI TTUWYEA DMVMIK2 MN Bacterial 50S ribosomal RNA (Bact 50S rRNA) DMVMIK2 MT DTT DMVMIK2 MA Inhibitor DMVMIK2 RN Molecular insights into 14-membered macrolides using the MM-PBSA method. J Chem Inf Model. 2009 Jun;49(6):1558-67. DMVMIK2 RU https://pubmed.ncbi.nlm.nih.gov/19469526 DMVMIK2 DI DMVMIK2 DMVMIK2 DN Roxithromycin DMVMIK2 MI DE4LYSA DMVMIK2 MN Cytochrome P450 3A4 (CYP3A4) DMVMIK2 MT DME DMVMIK2 MA Metabolism DMVMIK2 RN Hepatic veno-occlusive disease associated with immunosuppressive cyclophosphamide dosing and roxithromycin. Ann Pharmacother. 2006 Apr;40(4):767-70. DMVMIK2 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=16595573 DMVMIK2 DI DMVMIK2 DMVMIK2 DN Roxithromycin DMVMIK2 MI DTUGYRD DMVMIK2 MN P-glycoprotein 1 (ABCB1) DMVMIK2 MT DTP DMVMIK2 MA Substrate DMVMIK2 RN Differences in assessment of macrolide interaction with human MDR1 (ABCB1, P-gp) using rhodamine-123 efflux, ATPase activity and cellular accumulation assays. Eur J Pharm Sci. 2010 Sep 11;41(1):86-95. DMVMIK2 RU https://doi.org/10.1016/j.ejps.2010.05.016 DMMP65N DI DMMP65N DMMP65N DN Sertindole DMMP65N MI DECB0K3 DMMP65N MN Cytochrome P450 2D6 (CYP2D6) DMMP65N MT DME DMMP65N MA Metabolism DMMP65N RN Metabolic drug interactions with newer antipsychotics: a comparative review. Basic Clin Pharmacol Toxicol. 2007 Jan;100(1):4-22. DMMP65N RU https://www.ncbi.nlm.nih.gov/pubmed/?term=17214606 DMMP65N DI DMMP65N DMMP65N DN Sertindole DMMP65N MI DE4LYSA DMMP65N MN Cytochrome P450 3A4 (CYP3A4) DMMP65N MT DME DMMP65N MA Metabolism DMMP65N RN Metabolic drug interactions with newer antipsychotics: a comparative review. Basic Clin Pharmacol Toxicol. 2007 Jan;100(1):4-22. DMMP65N RU https://www.ncbi.nlm.nih.gov/pubmed/?term=17214606 DMMP65N DI DMMP65N DMMP65N DN Sertindole DMMP65N MI TTEX248 DMMP65N MN Dopamine D2 receptor (D2R) DMMP65N MT DTT DMMP65N MA Antagonist DMMP65N RN Effect of sertindole on extracellular dopamine, acetylcholine, and glutamate in the medial prefrontal cortex of conscious rats: a comparison with r... Psychopharmacology (Berl). 2009 Sep;206(1):39-49. DMMP65N RU https://pubmed.ncbi.nlm.nih.gov/19506838 DMKM5HB DI DMKM5HB DMKM5HB DN Sitaxsentan DMKM5HB MI DE5IED8 DMKM5HB MN Cytochrome P450 2C9 (CYP2C9) DMKM5HB MT DME DMKM5HB MA Metabolism DMKM5HB RN Interaction of acenocoumarol and sitaxentan in pulmonary arterial hypertension. Eur J Clin Invest. 2009 Jun;39 Suppl 2:14-8. DMKM5HB RU https://www.ncbi.nlm.nih.gov/pubmed/?term=19335742 DMKM5HB DI DMKM5HB DMKM5HB DN Sitaxsentan DMKM5HB MI TTKRD0G DMKM5HB MN Endothelin A receptor (EDNRA) DMKM5HB MT DTT DMKM5HB MA Antagonist DMKM5HB RN Emerging treatments for pulmonary arterial hypertension. Expert Opin Emerg Drugs. 2006 Nov;11(4):609-19. DMKM5HB RU https://pubmed.ncbi.nlm.nih.gov/17064221 DMBCK2S DI DMBCK2S DMBCK2S DN Sulfametopyrazine DMBCK2S MI TT4ILYC DMBCK2S MN Bacterial Dihydropteroate synthetase (Bact folP) DMBCK2S MT DTT DMBCK2S MA Inhibitor DMBCK2S RN Plasmodium falciparum dihydrofolate reductase Val-16 and Thr-108 mutation associated with in vivo resistance to antifolate drug: a case study. Indian J Malariol. 2001 Sep-Dec;38(3-4):76-83. DMBCK2S RU https://pubmed.ncbi.nlm.nih.gov/12125519 DMFR79T DI DMFR79T DMFR79T DN TBC 11251 (TBC) DMFR79T MI TTKRD0G DMFR79T MN Endothelin A receptor (EDNRA) DMFR79T MT DTT DMFR79T MA Antagonist DMFR79T RN Systemic administration of the endothelin-A receptor antagonist TBC 11251 attenuates cerebral vasospasm after experimental subarachnoid hemorrhage:... Neurosurgery. 1998 Dec;43(6):1409-17; discussion 1417-8. DMFR79T RU https://pubmed.ncbi.nlm.nih.gov/9848855 DM3TON2 DI DM3TON2 DM3TON2 DN Temafloxacin DM3TON2 MI TTN6J5F DM3TON2 MN Bacterial DNA gyrase (Bact gyrase) DM3TON2 MT DTT DM3TON2 MA Modulator DM3TON2 RN Mechanisms and frequency of resistance to temafloxacin. Am J Med. 1991 Dec 30;91(6A):27S-30S. DM3TON2 RU https://pubmed.ncbi.nlm.nih.gov/1662892 DM3TON2 DI DM3TON2 DM3TON2 DN Temafloxacin DM3TON2 MI DEJGDUW DM3TON2 MN Cytochrome P450 1A2 (CYP1A2) DM3TON2 MT DME DM3TON2 MA Metabolism DM3TON2 RN Inhibitory potency of quinolone antibacterial agents against cytochrome P450IA2 activity in vivo and in vitro. Antimicrob Agents Chemother. 1992 May;36(5):942-8. DM3TON2 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=1510417 DM4KLPT DI DM4KLPT DM4KLPT DN Terfenadine DM4KLPT MI DE5IED8 DM4KLPT MN Cytochrome P450 2C9 (CYP2C9) DM4KLPT MT DME DM4KLPT MA Metabolism DM4KLPT RN Effects of serum albumin and liver cytosol on CYP2C9- and CYP3A4-mediated drug metabolism. Drug Metab Pharmacokinet. 2002;17(6):522-31. DM4KLPT RU https://www.ncbi.nlm.nih.gov/pubmed/?term=15618707 DM4KLPT DI DM4KLPT DM4KLPT DN Terfenadine DM4KLPT MI DECB0K3 DM4KLPT MN Cytochrome P450 2D6 (CYP2D6) DM4KLPT MT DME DM4KLPT MA Metabolism DM4KLPT RN Metabolism of epinastine, a histamine H1 receptor antagonist, in human liver microsomes in comparison with that of terfenadine. Res Commun Mol Pathol Pharmacol. 1997 Dec;98(3):273-92. DM4KLPT RU https://www.ncbi.nlm.nih.gov/pubmed/?term=9485522 DM4KLPT DI DM4KLPT DM4KLPT DN Terfenadine DM4KLPT MI DE4LYSA DM4KLPT MN Cytochrome P450 3A4 (CYP3A4) DM4KLPT MT DME DM4KLPT MA Metabolism DM4KLPT RN Mechanism-based inhibition of cytochrome P450 3A4 by therapeutic drugs. Clin Pharmacokinet. 2005;44(3):279-304. DM4KLPT RU https://www.ncbi.nlm.nih.gov/pubmed/?term=15762770 DM4KLPT DI DM4KLPT DM4KLPT DN Terfenadine DM4KLPT MI DEIBDNY DM4KLPT MN Cytochrome P450 3A5 (CYP3A5) DM4KLPT MT DME DM4KLPT MA Metabolism DM4KLPT RN Drug Interactions Flockhart Table DM4KLPT RU https://drug-interactions.medicine.iu.edu/Main-Table.aspx DM4KLPT DI DM4KLPT DM4KLPT DN Terfenadine DM4KLPT MI DERD86B DM4KLPT MN Cytochrome P450 3A7 (CYP3A7) DM4KLPT MT DME DM4KLPT MA Metabolism DM4KLPT RN Drug Interactions Flockhart Table DM4KLPT RU https://drug-interactions.medicine.iu.edu/Main-Table.aspx DM4KLPT DI DM4KLPT DM4KLPT DN Terfenadine DM4KLPT MI TTTIBOJ DM4KLPT MN Histamine H1 receptor (H1R) DM4KLPT MT DTT DM4KLPT MA Antagonist DM4KLPT RN Small mouse cholangiocytes proliferate in response to H1 histamine receptor stimulation by activation of the IP3/CaMK I/CREB pathway. Am J Physiol Cell Physiol. 2008 Aug;295(2):C499-513. DM4KLPT RU https://pubmed.ncbi.nlm.nih.gov/18508907 DM4KLPT DI DM4KLPT DM4KLPT DN Terfenadine DM4KLPT MI DTUGYRD DM4KLPT MN P-glycoprotein 1 (ABCB1) DM4KLPT MT DTP DM4KLPT MA Substrate DM4KLPT RN Mammalian drug efflux transporters of the ATP binding cassette (ABC) family in multidrug resistance: A review of the past decade. Cancer Lett. 2016 Jan 1;370(1):153-64. DM4KLPT RU http://www.ncbi.nlm.nih.gov/pubmed/26499806 DMLFSTR DI DMLFSTR DMLFSTR DN Ticrynafen DMLFSTR MI DE5IED8 DMLFSTR MN Cytochrome P450 2C9 (CYP2C9) DMLFSTR MT DME DMLFSTR MA Metabolism DMLFSTR RN Cytochrome P450 enzymes and UDP-glucuronosyltransferases as hepatocellular autoantigens. Mol Biol Rep. 1996;23(3-4):235-42. DMLFSTR RU https://www.ncbi.nlm.nih.gov/pubmed/?term=9112234 DMABRJL DI DMABRJL DMABRJL DN Ximelagatran DMABRJL MI TT6L509 DMABRJL MN Coagulation factor IIa (F2) DMABRJL MT DTT DMABRJL MA Inhibitor DMABRJL RN Ximelagatran increases membrane fluidity and changes membrane lipid composition in primary human hepatocytes. Toxicol In Vitro. 2009 Oct;23(7):1305-10. DMABRJL RU https://pubmed.ncbi.nlm.nih.gov/19616086 DMABRJL DI DMABRJL DMABRJL DN Ximelagatran DMABRJL MI DE5IED8 DMABRJL MN Cytochrome P450 2C9 (CYP2C9) DMABRJL MT DME DMABRJL MA Metabolism DMABRJL RN Comparative pharmacokinetics of vitamin K antagonists: warfarin, phenprocoumon and acenocoumarol. Clin Pharmacokinet. 2005;44(12):1227-46. DMABRJL RU https://www.ncbi.nlm.nih.gov/pubmed/?term=16372822 DMABRJL DI DMABRJL DMABRJL DN Ximelagatran DMABRJL MI DTUGYRD DMABRJL MN P-glycoprotein 1 (ABCB1) DMABRJL MT DTP DMABRJL MA Substrate DMABRJL RN Human intestinal transporter database: QSAR modeling and virtual profiling of drug uptake, efflux and interactions. Pharm Res. 2013 Apr;30(4):996-1007. DMABRJL RU https://doi.org/10.1007/s11095-012-0935-x DMNI3U2 DI DMNI3U2 DMNI3U2 DN ZIMELIDINE DMNI3U2 MI TT3ROYC DMNI3U2 MN Serotonin transporter (SERT) DMNI3U2 MT DTT DMNI3U2 MA Inhibitor DMNI3U2 RN Nontricyclic antidepressant agents derived from cis- and trans-1-amino-4-aryltetralins. J Med Chem. 1984 Nov;27(11):1508-15. DMNI3U2 RU https://pubmed.ncbi.nlm.nih.gov/6492080 DM7APNJ DI DM7APNJ DM7APNJ DN Zomepirac DM7APNJ MI DE4LYSA DM7APNJ MN Cytochrome P450 3A4 (CYP3A4) DM7APNJ MT DME DM7APNJ MA Metabolism DM7APNJ RN Evidence for the bioactivation of zomepirac and tolmetin by an oxidative pathway: identification of glutathione adducts in vitro in human liver microsomes and in vivo in rats. Drug Metab Dispos. 2006 Jan;34(1):145-51. DM7APNJ RU https://www.ncbi.nlm.nih.gov/pubmed/?term=16251255 DM7APNJ DI DM7APNJ DM7APNJ DN Zomepirac DM7APNJ MI TTK0943 DM7APNJ MN Prostaglandin G/H synthase (COX) DM7APNJ MT DTT DM7APNJ MA Modulator DM7APNJ RN Effect of preischemia cyclooxygenase inhibition by zomepirac sodium on reflow, cerebral autoregulation, and EEG recovery in the cat after global ischemia. J Cereb Blood Flow Metab. 1986 Dec;6(6):691-702. DM7APNJ RU https://pubmed.ncbi.nlm.nih.gov/3098746 DMEQ3IW DI DMEQ3IW DMEQ3IW DN (S)-amisulpride DMEQ3IW MI TTEX248 DMEQ3IW MN Dopamine D2 receptor (D2R) DMEQ3IW MT DTT DMEQ3IW MA Antagonist DMEQ3IW RN The pipeline and future of drug development in schizophrenia. Mol Psychiatry. 2007 Oct;12(10):904-22. DMEQ3IW RU https://pubmed.ncbi.nlm.nih.gov/17667958 DMPL2KM DI DMPL2KM DMPL2KM DN GW-501516 DMPL2KM MI TT2JWF6 DMPL2KM MN Peroxisome proliferator-activated receptor delta (PPARD) DMPL2KM MT DTT DMPL2KM MA Modulator DMPL2KM RN Lipid effects of peroxisome proliferator-activated receptor- agonist GW501516 in subjects with low high-density lipoprotein cholesterol: characteristics of metabolic syndrome.Arterioscler Thromb Vasc Biol.2012 Sep;32(9):2289-94. DMPL2KM RU https://www.ncbi.nlm.nih.gov/pubmed/22814748 DMTF9YV DI DMTF9YV DMTF9YV DN AE-0047 DMTF9YV MI TT5HONZ DMTF9YV MN Calcium channel unspecific (CaC) DMTF9YV MT DTT DMTF9YV MA Modulator DMTF9YV RN AE0047-mediated calcium channel blocking in vascular smooth muscles. Gen Pharmacol. 1997 Sep;29(3):337-43. DMTF9YV RU https://pubmed.ncbi.nlm.nih.gov/9378237 DM7BN1A DI DM7BN1A DM7BN1A DN Bermoprofen DM7BN1A MI TTK0943 DM7BN1A MN Prostaglandin G/H synthase (COX) DM7BN1A MT DTT DM7BN1A MA Modulator DM7BN1A RN Prolongation of antipyretic action and reduction of gastric ulcerogenicity in the rat by controlled-release granules of bermoprofen, a new nonsteroidal anti-inflammatory drug. J Pharm Sci. 1991 Sep;80(9):876-80. DM7BN1A RU https://pubmed.ncbi.nlm.nih.gov/1800712 DM6E5VA DI DM6E5VA DM6E5VA DN Clinprost DM6E5VA MI TTOFYT1 DM6E5VA MN Prostacyclin receptor (PTGIR) DM6E5VA MT DTT DM6E5VA MA Modulator DM6E5VA RN Protective effect of a prostaglandin I2 analog, TEI-7165, on ischemic neuronal damage in gerbils. Brain Res. 1997 Sep 26;769(2):321-8. DM6E5VA RU https://pubmed.ncbi.nlm.nih.gov/9374201 DM3OUWC DI DM3OUWC DM3OUWC DN Domitroban DM3OUWC MI TT2O84V DM3OUWC MN Thromboxane A2 receptor (TBXA2R) DM3OUWC MT DTT DM3OUWC MA Antagonist DM3OUWC RN The effect of a novel thromboxane A2 (TXA2) receptor antagonist (S-1452) on the antigen-induced bronchoconstriction and airway hyperresponsiveness in guinea pigs. Prostaglandins Leukot Essent Fatty Acids. 1993 May;48(5):343-9. DM3OUWC RU https://pubmed.ncbi.nlm.nih.gov/7686675 DMFOEVQ DI DMFOEVQ DMFOEVQ DN Ecabapide DMFOEVQ MI TT2NUT5 DMFOEVQ MN Adrenergic receptor alpha-2C (ADRA2C) DMFOEVQ MT DTT DMFOEVQ MA Modulator DMFOEVQ RN Identification of major biliary and urinary metabolites of ecabapide in rats. Xenobiotica. 1996 Sep;26(9):983-94. DMFOEVQ RU https://pubmed.ncbi.nlm.nih.gov/8893045 DMKQI7S DI DMKQI7S DMKQI7S DN EMITEFUR DMKQI7S MI TTU6BFZ DMKQI7S MN Candida Thymidylate synthase (Candi TMP1) DMKQI7S MT DTT DMKQI7S MA Inhibitor DMKQI7S RN Antitumor activity of fluoropyrimidines and thymidylate synthetase inhibition. Jpn J Cancer Res. 1991 Apr;82(4):476-82. DMKQI7S RU https://pubmed.ncbi.nlm.nih.gov/1904428 DML1Y49 DI DML1Y49 DML1Y49 DN Epanolol DML1Y49 MI TTMXGCW DML1Y49 MN Adrenergic receptor beta-3 (ADRB3) DML1Y49 MT DTT DML1Y49 MA Modulator DML1Y49 RN Pharmacokinetics of epanolol after acute and chronic oral dosing in elderly patients with stable angina pectoris. Br J Clin Pharmacol. 1990 Mar;29(3):333-7. DML1Y49 RU https://pubmed.ncbi.nlm.nih.gov/1968755 DML1Y49 DI DML1Y49 DML1Y49 DN Epanolol DML1Y49 MI DECB0K3 DML1Y49 MN Cytochrome P450 2D6 (CYP2D6) DML1Y49 MT DME DML1Y49 MA Metabolism DML1Y49 RN Application of substrate depletion assay to evaluation of CYP isoforms responsible for stereoselective metabolism of carvedilol. Drug Metab Pharmacokinet. 2016 Dec;31(6):425-432. DML1Y49 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=27836712 DM05MCO DI DM05MCO DM05MCO DN Inaperisone DM05MCO MI TTJSZTB DM05MCO MN Nicotinic acetylcholine receptor (nAChR) DM05MCO MT DTT DM05MCO MA Modulator DM05MCO RN Inhibitory effect of inaperisone hydrochloride (inaperisone), a new centrally acting muscle relaxant, on the micturition reflex. Eur J Pharmacol. 1992 Mar 31;213(3):409-15. DM05MCO RU https://pubmed.ncbi.nlm.nih.gov/1618281 DM1B8NU DI DM1B8NU DM1B8NU DN Isbogrel DM1B8NU MI TT2GVH5 DM1B8NU MN Isomerase unspecific (IsoM) DM1B8NU MT DTT DM1B8NU MA Modulator DM1B8NU RN Beneficial effect of CV-4151 (Isbogrel), a thromboxane A2 synthase inhibitor, in a rat middle cerebral artery thrombosis model. Thromb Res. 1995 Jul 1;79(1):95-107. DM1B8NU RU https://pubmed.ncbi.nlm.nih.gov/7495108 DMXZ4BK DI DMXZ4BK DMXZ4BK DN LAS-41001 DMXZ4BK MI TTOD7B3 DMXZ4BK MN Retinoic acid receptor (RAR) DMXZ4BK MT DTT DMXZ4BK MA Modulator DMXZ4BK RN Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800027956) DMXZ4BK RU http://adisinsight.springer.com/drugs/800027956 DMBKNJT DI DMBKNJT DMBKNJT DN LEMINOPRAZOLE DMBKNJT MI TTLOKXP DMBKNJT MN Gastric H(+)/K(+) ATPase (Proton pump) DMBKNJT MT DTT DMBKNJT MA Modulator DMBKNJT RN Vasoinhibitory effect of leminoprazole, a H+,K(+)-ATPase inhibitor, on rat aortic rings. Gen Pharmacol. 1996 Jan;27(1):117-21. DMBKNJT RU https://www.ncbi.nlm.nih.gov/pubmed/8742507 DMNS4TK DI DMNS4TK DMNS4TK DN Levcromakalim DMNS4TK MI TT1VOHK DMNS4TK MN Potassium channel unspecific (KC) DMNS4TK MT DTT DMNS4TK MA Modulator DMNS4TK RN The potassium channel opener levcromakalim causes expansive remodelling of experimental vein grafts. J Vasc Surg. 2006 Jul;44(1):159-65. DMNS4TK RU https://www.ncbi.nlm.nih.gov/pubmed/16828441 DMFGMD9 DI DMFGMD9 DMFGMD9 DN LUBELUZOLE DMFGMD9 MI TTRK8B9 DMFGMD9 MN Sodium channel unspecific (NaC) DMFGMD9 MT DTT DMFGMD9 MA Inhibitor DMFGMD9 RN Medicinal chemistry of neuronal voltage-gated sodium channel blockers. J Med Chem. 2001 Jan 18;44(2):115-37. DMFGMD9 RU https://pubmed.ncbi.nlm.nih.gov/11170622 DMFGMD9 DI DMFGMD9 DMFGMD9 DN LUBELUZOLE DMFGMD9 MI TTZOVE0 DMFGMD9 MN Voltage-gated sodium channel alpha Nav1.5 (SCN5A) DMFGMD9 MT DTT DMFGMD9 MA Inhibitor DMFGMD9 RN Medicinal chemistry of neuronal voltage-gated sodium channel blockers. J Med Chem. 2001 Jan 18;44(2):115-37. DMFGMD9 RU https://pubmed.ncbi.nlm.nih.gov/11170622 DMEQDHP DI DMEQDHP DMEQDHP DN Meluadrine DMEQDHP MI TT2CJVK DMEQDHP MN Adrenergic receptor beta-2 (ADRB2) DMEQDHP MT DTT DMEQDHP MA Modulator DMEQDHP RN Effects of meluadrine tartrate and ritodrine hydrochloride on oxytocin-induced uterine contraction, uterine arterial blood flow and maternal cardiovascular function in pregnant goats. Jpn J Pharmacol. 2002 Oct;90(2):107-13. DMEQDHP RU https://pubmed.ncbi.nlm.nih.gov/12419879 DM9ADLQ DI DM9ADLQ DM9ADLQ DN Monatepil maleate DM9ADLQ MI TT5HONZ DM9ADLQ MN Calcium channel unspecific (CaC) DM9ADLQ MT DTT DM9ADLQ MA Modulator DM9ADLQ RN Antihypertensive, antiatherosclerotic, and plasma lipid-lowering effects of monatepil, a novel calcium antagonist with alpha 1-adrenoceptor-blocking activity in experimental animals. Am J Hypertens. 1994 Oct;7(10 Pt 2):131S-40S. DM9ADLQ RU https://pubmed.ncbi.nlm.nih.gov/7826563 DM31OGZ DI DM31OGZ DM31OGZ DN MONTIRELIN TETRAHYDRATE DM31OGZ MI TT4J8MF DM31OGZ MN Thyrotropin-releasing hormone receptor (TRHR) DM31OGZ MT DTT DM31OGZ MA Modulator DM31OGZ RN Montirelin hydrate (NS-3), a TRH analog, improved the disturbance of consciousness caused by head concussion and pentobarbital in mice. Nihon Yakurigaku Zasshi. 1996 May;107(5):237-45. DM31OGZ RU https://pubmed.ncbi.nlm.nih.gov/8690305 DMXF0NS DI DMXF0NS DMXF0NS DN Norastemizole DMXF0NS MI TTTIBOJ DMXF0NS MN Histamine H1 receptor (H1R) DMXF0NS MT DTT DMXF0NS MA Modulator DMXF0NS RN Effect of tecastemizole on pulmonary and cutaneous allergic inflammatory responses. Clin Exp Allergy. 2007 Jun;37(6):909-17. DMXF0NS RU https://www.ncbi.nlm.nih.gov/pubmed/17517105 DMUH0KO DI DMUH0KO DMUH0KO DN Palonidipine hydrochloride DMUH0KO MI TT5HONZ DMUH0KO MN Calcium channel unspecific (CaC) DMUH0KO MT DTT DMUH0KO MA Modulator DMUH0KO RN Effect of palonidipine hydrochloride (TC-81), a novel calcium antagonist, on the canine coronary artery. Nihon Yakurigaku Zasshi. 1993 Jul;102(1):23-33. DMUH0KO RU https://pubmed.ncbi.nlm.nih.gov/8335285 DMP6BG4 DI DMP6BG4 DMP6BG4 DN Pirazolac DMP6BG4 MI TTK0943 DMP6BG4 MN Prostaglandin G/H synthase (COX) DMP6BG4 MT DTT DMP6BG4 MA Modulator DMP6BG4 RN Differential dosing study of pirazolac, a new non-steroidal anti-inflammatory agent, in patients with rheumatoid arthritis. Curr Med Res Opin. 1985;9(8):542-7. DMP6BG4 RU https://pubmed.ncbi.nlm.nih.gov/3896664 DMD8K3B DI DMD8K3B DMD8K3B DN PW-2101 DMD8K3B MI TTMXGCW DMD8K3B MN Adrenergic receptor beta-3 (ADRB3) DMD8K3B MT DTT DMD8K3B MA Antagonist DMD8K3B RN PW 2101 Penwest discontinued, USA (hypertension) Penwest non-approvable, USA (hypertension), R & D Focus Drug News. July 11, 2005 DMD8K3B RU http://business.highbeam.com/436989/article-1G1-133855652/pw-2101-penwest-discontinued-usa DM4LSJ2 DI DM4LSJ2 DM4LSJ2 DN Satigrel DM4LSJ2 MI TTKNWZ4 DM4LSJ2 MN Thromboxane-A synthase (TBXAS1) DM4LSJ2 MT DTT DM4LSJ2 MA Modulator DM4LSJ2 RN Mechanisms of satigrel (E5510), a new anti-platelet drug, in inhibiting human platelet aggregation. Selectivity and potency against prostaglandin H synthases isozyme activities and phosphodiesterase isoform activities. Biol Pharm Bull. 1996 Jun;19(6):828-33. DM4LSJ2 RU https://pubmed.ncbi.nlm.nih.gov/8799481 DMYBPJ1 DI DMYBPJ1 DMYBPJ1 DN Semotiadil DMYBPJ1 MI TT5HONZ DMYBPJ1 MN Calcium channel unspecific (CaC) DMYBPJ1 MT DTT DMYBPJ1 MA Blocker DMYBPJ1 RN Thyroid hypertrophic effect of semotiadil fumarate, a new calcium antagonist, in rats. J Toxicol Sci. 2000 May;25(2):121-30. DMYBPJ1 RU https://pubmed.ncbi.nlm.nih.gov/10845190 DMC14HL DI DMC14HL DMC14HL DN Suriclone DMC14HL MI TTEX6LM DMC14HL MN GABA(A) receptor gamma-3 (GABRG3) DMC14HL MT DTT DMC14HL MA Modulator DMC14HL RN The effect of cyclopyrrolones on GABAA receptor function is different from that of benzodiazepines. Naunyn Schmiedebergs Arch Pharmacol. 1994 Sep;350(3):294-300. DMC14HL RU https://www.ncbi.nlm.nih.gov/pubmed/7824046 DM6PVWS DI DM6PVWS DM6PVWS DN Telenzepine DM6PVWS MI TTOXS3C DM6PVWS MN Muscarinic acetylcholine receptor (CHRM) DM6PVWS MT DTT DM6PVWS MA Antagonist DM6PVWS RN The existence of stable enantiomers of telenzepine and their stereoselective interaction with muscarinic receptor subtypes. Mol Pharmacol. 1989 Apr;35(4):477-83. DM6PVWS RU https://pubmed.ncbi.nlm.nih.gov/2704371 DM6PVWS DI DM6PVWS DM6PVWS DN Telenzepine DM6PVWS MI TTZ9SOR DM6PVWS MN Muscarinic acetylcholine receptor M1 (CHRM1) DM6PVWS MT DTT DM6PVWS MA Modulator DM6PVWS RN Effect of telenzepine, an M1-selective muscarinic receptor antagonist, in patients with nocturnal asthma. Pulm Pharmacol. 1994 Apr;7(2):91-7. DM6PVWS RU https://pubmed.ncbi.nlm.nih.gov/8081076 DMUM3CP DI DMUM3CP DMUM3CP DN 15(S)-hydroxyeicosatetraenoic acid (ophthalmic, dry eye), Alcon DMUM3CP MI TTHBUXE DMUM3CP MN Mucin (MUC) DMUM3CP MT DTT DMUM3CP MA Modulator DMUM3CP RN 15(S)-hydroxyeicosatetraenoic acid (15-HETE), a product of arachidonic acid peroxidation, is an active component of hemozoin toxicity to monocytes. Parassitologia. 1999 Sep;41(1-3):199-202. DMUM3CP RU https://pubmed.ncbi.nlm.nih.gov/10697856 DM0GMJ6 DI DM0GMJ6 DM0GMJ6 DN 2085-P DM0GMJ6 MI TTHI19T DM0GMJ6 MN Staphylococcus Beta-lactamase (Stap-coc blaZ) DM0GMJ6 MT DTT DM0GMJ6 MA Modulator DM0GMJ6 RN US patent application no. 2004,0023,290, Novel therapeutic agents that modulate enzymatic processes. DM0GMJ6 RU http://www.google.com/patents/US20040023290 DM09GSW DI DM09GSW DM09GSW DN Abafungin DM09GSW MI TTTSOUD DM09GSW MN Candida Cytochrome P450 51 (Candi ERG11) DM09GSW MT DTT DM09GSW MA Inhibitor DM09GSW RN Upregulation of sterol C14-demethylase expression in Trypanosoma cruzi treated with sterol biosynthesis inhibitors. Mol Biochem Parasitol. 2005 Nov;144(1):68-75. DM09GSW RU https://pubmed.ncbi.nlm.nih.gov/16165233 DMAENDF DI DMAENDF DMAENDF DN Abetimus sodium DMAENDF MI TTUTN1I DMAENDF MN Human Deoxyribonucleic acid (hDNA) DMAENDF MT DTT DMAENDF MA Inhibitor DMAENDF RN Emergence of targeted immune therapies for systemic lupus. Expert Opin Emerg Drugs. 2005 Feb;10(1):53-65. DMAENDF RU https://pubmed.ncbi.nlm.nih.gov/15757403 DMNKZ61 DI DMNKZ61 DMNKZ61 DN Ablukast DMNKZ61 MI TTGKOY9 DMNKZ61 MN Leukotriene CysLT1 receptor (CYSLTR1) DMNKZ61 MT DTT DMNKZ61 MA Modulator DMNKZ61 RN Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41. DMNKZ61 RU https://www.ncbi.nlm.nih.gov/pubmed/15950434 DMKM543 DI DMKM543 DMKM543 DN Acecainide DMKM543 MI TT1VOHK DMKM543 MN Potassium channel unspecific (KC) DMKM543 MT DTT DMKM543 MA Opener DMKM543 RN Acecainide (N-acetylprocainamide). A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic potential in cardiac arrhythmias. Drugs. 1990 May;39(5):720-40. DMKM543 RU https://pubmed.ncbi.nlm.nih.gov/1693889 DMKM543 DI DMKM543 DMKM543 DN Acecainide DMKM543 MI TTZOVE0 DMKM543 MN Voltage-gated sodium channel alpha Nav1.5 (SCN5A) DMKM543 MT DTT DMKM543 MA Blocker DMKM543 RN Monoamine transporter and sodium channel mechanisms in the rapid pressor response to cocaine. Pharmacol Biochem Behav. 1998 Feb;59(2):305-12. DMKM543 RU https://pubmed.ncbi.nlm.nih.gov/9476974 DMPQZ80 DI DMPQZ80 DMPQZ80 DN Acivicin DMPQZ80 MI TTN12BZ DMPQZ80 MN CTP synthase (CTPS1) DMPQZ80 MT DTT DMPQZ80 MA Inhibitor DMPQZ80 RN Synergistic effects with inhibitors of de novo pyrimidine synthesis, acivicin, and N-(phosphonacetyl)-L-aspartic acid. Cancer Res. 1981 Sep;41(9 Pt 1):3419-23. DMPQZ80 RU https://pubmed.ncbi.nlm.nih.gov/7260907 DMPQZ80 DI DMPQZ80 DMPQZ80 DN Acivicin DMPQZ80 MI TT5XOKS DMPQZ80 MN Leishmania Carbamoyl-phosphate synthase (Leishm CPS) DMPQZ80 MT DTT DMPQZ80 MA Inhibitor DMPQZ80 RN Acivicin: a highly active potential chemotherapeutic agent against visceral leishmaniasis. Biochem Biophys Res Commun. 1990 Jul 31;170(2):426-32. DMPQZ80 RU https://pubmed.ncbi.nlm.nih.gov/2383250 DMTG18I DI DMTG18I DMTG18I DN Aleglitazar DMTG18I MI DES5XRU DMTG18I MN Cytochrome P450 2C8 (CYP2C8) DMTG18I MT DME DMTG18I MA Metabolism DMTG18I RN Exposure and response analysis of aleglitazar on cardiovascular risk markers and safety outcomes: an analysis of the AleCardio trial. Diabetes Obes Metab. 2020 Jan;22(1):30-38. DMTG18I RU https://www.ncbi.nlm.nih.gov/pubmed/?term=31468659 DMTG18I DI DMTG18I DMTG18I DN Aleglitazar DMTG18I MI TTJ584C DMTG18I MN Peroxisome proliferator-activated receptor alpha (PPARA) DMTG18I MT DTT DMTG18I MA Agonist DMTG18I RN Clinical pipeline report, company report or official report of Roche (2009). DMTG18I RU http://www.roche.com/research_and_development/pipeline/roche_pharma_pipeline.htm DMV2Y6L DI DMV2Y6L DMV2Y6L DN Alinidine DMV2Y6L MI TT1VOHK DMV2Y6L MN Potassium channel unspecific (KC) DMV2Y6L MT DTT DMV2Y6L MA Blocker DMV2Y6L RN Decrease in bradycardic effect of AQ-A 39 and alinidine in guinea-pig sinoatrial node depolarized by high external K+-concentration. Naunyn Schmiedebergs Arch Pharmacol. 1984 Dec;328(2):210-3. DMV2Y6L RU https://pubmed.ncbi.nlm.nih.gov/6527706 DMV3PEA DI DMV3PEA DMV3PEA DN Almokalant DMV3PEA MI TT1VOHK DMV3PEA MN Potassium channel unspecific (KC) DMV3PEA MT DTT DMV3PEA MA Modulator DMV3PEA RN Effect of almokalant, a selective potassium channel blocker, on the termination and inducibility of paroxysmal supraventricular tachycardias: a study in patients with Wolff-Parkinson-White syndrome and atrioventricular nodal reentrant tachycardia.Almokalant PSVT Study Group.J Cardiovasc Pharmacol.1995 Aug;26(2):198-206. DMV3PEA RU https://www.ncbi.nlm.nih.gov/pubmed/7475043 DMFE3CT DI DMFE3CT DMFE3CT DN Alniditan DMFE3CT MI TTK8CXU DMFE3CT MN 5-HT 1B receptor (HTR1B) DMFE3CT MT DTT DMFE3CT MA Agonist DMFE3CT RN Agonistic properties of alniditan, sumatriptan and dihydroergotamine on human 5-HT1B and 5-HT1D receptors expressed in various mammalian cell lines. Br J Pharmacol. 1998 Apr;123(8):1655-65. DMFE3CT RU https://pubmed.ncbi.nlm.nih.gov/9605573 DMFE3CT DI DMFE3CT DMFE3CT DN Alniditan DMFE3CT MI TT6MSOK DMFE3CT MN 5-HT 1D receptor (HTR1D) DMFE3CT MT DTT DMFE3CT MA Agonist DMFE3CT RN Agonistic properties of alniditan, sumatriptan and dihydroergotamine on human 5-HT1B and 5-HT1D receptors expressed in various mammalian cell lines. Br J Pharmacol. 1998 Apr;123(8):1655-65. DMFE3CT RU https://pubmed.ncbi.nlm.nih.gov/9605573 DMGW07M DI DMGW07M DMGW07M DN Aloxistatin DMGW07M MI TTG5QB7 DMGW07M MN Calpain-2 (CAPN2) DMGW07M MT DTT DMGW07M MA Inhibitor DMGW07M RN In silico identification and biochemical evaluation of novel inhibitors of NRH:quinone oxidoreductase 2 (NQO2). Bioorg Med Chem Lett. 2010 Dec 15;20(24):7331-6. DMGW07M RU https://pubmed.ncbi.nlm.nih.gov/21074425 DMGW07M DI DMGW07M DMGW07M DN Aloxistatin DMGW07M MI TTQAJF1 DMGW07M MN Cathepsin G (CTSG) DMGW07M MT DTT DMGW07M MA Inhibitor DMGW07M RN Inhibition of the activation of multiple serine proteases with a cathepsin C inhibitor requires sustained exposure to prevent pro-enzyme processing. J Biol Chem. 2007 Jul 20;282(29):20836-46. DMGW07M RU https://pubmed.ncbi.nlm.nih.gov/17535802 DMPS14M DI DMPS14M DMPS14M DN Amibegron DMPS14M MI TTMXGCW DMPS14M MN Adrenergic receptor beta-3 (ADRB3) DMPS14M MT DTT DMPS14M MA Agonist DMPS14M RN Novel drugs and therapeutic targets for severe mood disorders. Neuropsychopharmacology. 2008 Aug;33(9):2080-92. DMPS14M RU https://pubmed.ncbi.nlm.nih.gov/18172433 DMNEM2C DI DMNEM2C DMNEM2C DN Anipamil DMNEM2C MI TT5HONZ DMNEM2C MN Calcium channel unspecific (CaC) DMNEM2C MT DTT DMNEM2C MA Modulator DMNEM2C RN Effects of the novel calcium channel blocker, anipamil, on the isolated rabbit heart. Comparison with verapamil and gallopamil. Naunyn Schmiedebergs Arch Pharmacol. 1992 Sep;346(3):339-44. DMNEM2C RU https://pubmed.ncbi.nlm.nih.gov/1383837 DM8XO3B DI DM8XO3B DM8XO3B DN ARANOSE DM8XO3B MI TTUTN1I DM8XO3B MN Human Deoxyribonucleic acid (hDNA) DM8XO3B MT DTT DM8XO3B MA Binder DM8XO3B RN Alternative DNA loops regulate the arabinose operon in Escherichia coli. Proc Natl Acad Sci U S A. 1988 Aug;85(15):5444-8. DM8XO3B RU https://pubmed.ncbi.nlm.nih.gov/3041410 DM4BV2W DI DM4BV2W DM4BV2W DN Asoprisnil DM4BV2W MI TTUV8G9 DM4BV2W MN Progesterone receptor (PGR) DM4BV2W MT DTT DM4BV2W MA Modulator DM4BV2W RN New drugs in development for the treatment of endometriosis. Expert Opin Investig Drugs. 2008 Aug;17(8):1187-202. DM4BV2W RU https://pubmed.ncbi.nlm.nih.gov/18616415 DMPTG39 DI DMPTG39 DMPTG39 DN Ataprost DMPTG39 MI TTOFYT1 DMPTG39 MN Prostacyclin receptor (PTGIR) DMPTG39 MT DTT DMPTG39 MA Modulator DMPTG39 RN Pharmacokinetics of intravenous ataprost alfadex, a new prostaglandin I2 analog in healthy volunteers. Int J Clin Pharmacol Ther Toxicol. 1993 Aug;31(8):373-5. DMPTG39 RU https://pubmed.ncbi.nlm.nih.gov/8225681 DMFG4OM DI DMFG4OM DMFG4OM DN Avasimibe DMFG4OM MI TTMF541 DMFG4OM MN Liver carboxylesterase (CES1) DMFG4OM MT DTT DMFG4OM MA Inhibitor DMFG4OM RN New advances in lipid-modifying therapies for reducing cardiovascular risk. Cardiology. 2002;97(2):59-66. DMFG4OM RU https://pubmed.ncbi.nlm.nih.gov/11978950 DM3SE2N DI DM3SE2N DM3SE2N DN Avitriptan DM3SE2N MI TT6MSOK DM3SE2N MN 5-HT 1D receptor (HTR1D) DM3SE2N MT DTT DM3SE2N MA Agonist DM3SE2N RN Safety trial with the 5HT1B/1D agonist avitriptan (BMS-180048) in patients with migraine who have experienced pressure, tightness, and/or pain in the chest, neck, and/or throat following sumatriptan.Cephalalgia. 1998 Oct;18(8):546-51. DM3SE2N RU https://pubmed.ncbi.nlm.nih.gov/9827246 DMT5O8I DI DMT5O8I DMT5O8I DN Axokine DMT5O8I MI TTY84UG DMT5O8I MN Acetyl-CoA carboxylase 2 (ACACB) DMT5O8I MT DTT DMT5O8I MA Inhibitor DMT5O8I RN Obesity: pathophysiology and clinical management. Curr Med Chem. 2009;16(4):506-21. DMT5O8I RU https://pubmed.ncbi.nlm.nih.gov/19199918 DM7G8T0 DI DM7G8T0 DM7G8T0 DN Azithromycin/chloroquine DM7G8T0 MI TTUWYEA DM7G8T0 MN Bacterial 50S ribosomal RNA (Bact 50S rRNA) DM7G8T0 MT DTT DM7G8T0 MA Binder DM7G8T0 RN Pfizer. Product Development Pipeline. March 31 2009. DM7G8T0 RU http://media.pfizer.com/files/research/pipeline/2009_0331/pipeline_2009_0331.pdf DM7G8T0 DI DM7G8T0 DM7G8T0 DN Azithromycin/chloroquine DM7G8T0 MI DTFI42L DM7G8T0 MN Multidrug resistance-associated protein 2 (ABCC2) DM7G8T0 MT DTP DM7G8T0 MA Substrate DM7G8T0 RN Possible involvement of the drug transporters P glycoprotein and multidrug resistance-associated protein Mrp2 in disposition of azithromycin. Antimicrob Agents Chemother. 2004 Mar;48(3):809-14. DM7G8T0 RU http://www.ncbi.nlm.nih.gov/pubmed/14982769 DM7G8T0 DI DM7G8T0 DM7G8T0 DN Azithromycin/chloroquine DM7G8T0 MI DTUGYRD DM7G8T0 MN P-glycoprotein 1 (ABCB1) DM7G8T0 MT DTP DM7G8T0 MA Substrate DM7G8T0 RN Resveratrol modifies biliary secretion of cholephilic compounds in sham-operated and cholestatic rats. World J Gastroenterol. 2017 Nov 21;23(43):7678-7692. DM7G8T0 RU http://www.ncbi.nlm.nih.gov/pubmed/29209109 DMAMFXC DI DMAMFXC DMAMFXC DN BCG65-E7 DMAMFXC MI TTD24Y0 DMAMFXC MN Toll-like receptor 3 (TLR3) DMAMFXC MT DTT DMAMFXC MA Agonist DMAMFXC RN Serological response to an HPV16 E7 based therapeutic vaccine in women with high-grade cervical dysplasia. Gynecol Oncol. 2010 Feb;116(2):208-12. DMAMFXC RU https://pubmed.ncbi.nlm.nih.gov/19555999 DMRQV8I DI DMRQV8I DMRQV8I DN Becatecarin DMRQV8I MI DTI7UX6 DMRQV8I MN Breast cancer resistance protein (ABCG2) DMRQV8I MT DTP DMRQV8I MA Substrate DMRQV8I RN Becatecarin (rebeccamycin analog, NSC 655649) is a transport substrate and induces expression of the ATP-binding cassette transporter, ABCG2, in lung carcinoma cells. Cancer Chemother Pharmacol. 2009 Aug;64(3):575-83. DMRQV8I RU https://doi.org/10.1007/s00280-008-0908-2 DMRQV8I DI DMRQV8I DMRQV8I DN Becatecarin DMRQV8I MI TTGTQHC DMRQV8I MN DNA topoisomerase I (TOP1) DMRQV8I MT DTT DMRQV8I MA Modulator DMRQV8I RN Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41. DMRQV8I RU https://www.ncbi.nlm.nih.gov/pubmed/15950434 DMZIV6D DI DMZIV6D DMZIV6D DN Befloxatone DMZIV6D MI DTI7UX6 DMZIV6D MN Breast cancer resistance protein (ABCG2) DMZIV6D MT DTP DMZIV6D MA Substrate DMZIV6D RN Transport of selected PET radiotracers by human P-glycoprotein (ABCB1) and breast cancer resistance protein (ABCG2): an in vitro screening. J Nucl Med. 2011 Mar;52(3):415-23. DMZIV6D RU https://doi.org/10.2967/jnumed.110.079608 DMZIV6D DI DMZIV6D DMZIV6D DN Befloxatone DMZIV6D MI TT3WG5C DMZIV6D MN Monoamine oxidase type A (MAO-A) DMZIV6D MT DTT DMZIV6D MA Inhibitor DMZIV6D RN Befloxatone, a new reversible and selective monoamine oxidase-A inhibitor. II. Pharmacological profile. J Pharmacol Exp Ther. 1996 Apr;277(1):265-77. DMZIV6D RU https://pubmed.ncbi.nlm.nih.gov/8613929 DMSPJX9 DI DMSPJX9 DMSPJX9 DN BEMESETRON DMSPJX9 MI TTPC4TU DMSPJX9 MN 5-HT 3A receptor (HTR3A) DMSPJX9 MT DTT DMSPJX9 MA Inhibitor DMSPJX9 RN Zatosetron, a potent, selective, and long-acting 5HT3 receptor antagonist: synthesis and structure-activity relationships. J Med Chem. 1992 Jan 24;35(2):310-9. DMSPJX9 RU https://pubmed.ncbi.nlm.nih.gov/1732548 DMSPJX9 DI DMSPJX9 DMSPJX9 DN BEMESETRON DMSPJX9 MI TTR6K75 DMSPJX9 MN 5-HT 3B receptor (HTR3B) DMSPJX9 MT DTT DMSPJX9 MA Inhibitor DMSPJX9 RN Zatosetron, a potent, selective, and long-acting 5HT3 receptor antagonist: synthesis and structure-activity relationships. J Med Chem. 1992 Jan 24;35(2):310-9. DMSPJX9 RU https://pubmed.ncbi.nlm.nih.gov/1732548 DMSPJX9 DI DMSPJX9 DMSPJX9 DN BEMESETRON DMSPJX9 MI TTJFY5U DMSPJX9 MN Adenosine A3 receptor (ADORA3) DMSPJX9 MT DTT DMSPJX9 MA Inhibitor DMSPJX9 RN 2-n-Butyl-9-methyl-8-[1,2,3]triazol-2-yl-9H-purin-6-ylamine and analogues as A2A adenosine receptor antagonists. Design, synthesis, and pharmacolog... J Med Chem. 2005 Nov 3;48(22):6887-96. DMSPJX9 RU https://pubmed.ncbi.nlm.nih.gov/16250647 DMIEB8Y DI DMIEB8Y DMIEB8Y DN Bevasiranib DMIEB8Y MI TTOHSBA DMIEB8Y MN Vascular endothelial growth factor A (VEGFA) DMIEB8Y MT DTT DMIEB8Y MA Modulator DMIEB8Y RN Bevasiranib for the Treatment of Wet, Age-Related Macular Degeneration DMIEB8Y RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3661434 DM47ZHW DI DM47ZHW DM47ZHW DN Bidisomide DM47ZHW MI TTRK8B9 DM47ZHW MN Sodium channel unspecific (NaC) DM47ZHW MT DTT DM47ZHW MA Modulator DM47ZHW RN Bidisomide (SC-40230), a new antiarrhythmic agent: initial study of tolerability and pharmacokinetics. Clin Pharmacol Ther. 1992 Apr;51(4):371-8. DM47ZHW RU https://pubmed.ncbi.nlm.nih.gov/1563207 DMOQIMS DI DMOQIMS DMOQIMS DN Bifeprunox DMOQIMS MI TTSQIFT DMOQIMS MN 5-HT 1A receptor (HTR1A) DMOQIMS MT DTT DMOQIMS MA Modulator DMOQIMS RN Bifeprunox: a partial agonist at dopamine D2 and serotonin 1A receptors, influences nicotine-seeking behaviour in response to drug-associated stimuli in rats.Addict Biol.2012 Mar;17(2):274-86. DMOQIMS RU https://www.ncbi.nlm.nih.gov/pubmed/21521422 DMOQIMS DI DMOQIMS DMOQIMS DN Bifeprunox DMOQIMS MI TTEX248 DMOQIMS MN Dopamine D2 receptor (D2R) DMOQIMS MT DTT DMOQIMS MA Modulator DMOQIMS RN Bifeprunox: a partial agonist at dopamine D2 and serotonin 1A receptors, influences nicotine-seeking behaviour in response to drug-associated stimuli in rats.Addict Biol.2012 Mar;17(2):274-86. DMOQIMS RU https://www.ncbi.nlm.nih.gov/pubmed/21521422 DMLXHZR DI DMLXHZR DMLXHZR DN BL-1832 DMLXHZR MI TTZPO1L DMLXHZR MN Substance-P receptor (TACR1) DMLXHZR MT DTT DMLXHZR MA Antagonist DMLXHZR RN WO patent application no. 2006,0132,05, Neurokinin-1 receptor antagonists for the treatment of conditions responsive to testosterone elevation. DMLXHZR RU http://worldwide.espacenet.com/publicationDetails/biblio?DB=worldwide.espacenet.com&II=0&ND=3&adjacent=true&locale=en_EP&FT=D&date=20060209&CC=WO&NR=2006013205A1&KC=A1 DMKSFPE DI DMKSFPE DMKSFPE DN BMS 275291 DMKSFPE MI TTMX39J DMKSFPE MN Matrix metalloproteinase-1 (MMP-1) DMKSFPE MT DTT DMKSFPE MA Inhibitor DMKSFPE RN Phase 1/2 trial of BMS-275291 in patients with human immunodeficiency virus-related Kaposi sarcoma: a multicenter trial of the AIDS Malignancy Consortium. Cancer. 2008 Mar 1;112(5):1083-8. DMKSFPE RU https://pubmed.ncbi.nlm.nih.gov/18224669 DMKSFPE DI DMKSFPE DMKSFPE DN BMS 275291 DMKSFPE MI TTLM12X DMKSFPE MN Matrix metalloproteinase-2 (MMP-2) DMKSFPE MT DTT DMKSFPE MA Inhibitor DMKSFPE RN Phase 1/2 trial of BMS-275291 in patients with human immunodeficiency virus-related Kaposi sarcoma: a multicenter trial of the AIDS Malignancy Consortium. Cancer. 2008 Mar 1;112(5):1083-8. DMKSFPE RU https://pubmed.ncbi.nlm.nih.gov/18224669 DMKSFPE DI DMKSFPE DMKSFPE DN BMS 275291 DMKSFPE MI TTMTWOS DMKSFPE MN Matrix metalloproteinase-7 (MMP-7) DMKSFPE MT DTT DMKSFPE MA Inhibitor DMKSFPE RN Phase 1/2 trial of BMS-275291 in patients with human immunodeficiency virus-related Kaposi sarcoma: a multicenter trial of the AIDS Malignancy Consortium. Cancer. 2008 Mar 1;112(5):1083-8. DMKSFPE RU https://pubmed.ncbi.nlm.nih.gov/18224669 DM0HR5W DI DM0HR5W DM0HR5W DN BMS-181100 DM0HR5W MI TTSQIFT DM0HR5W MN 5-HT 1A receptor (HTR1A) DM0HR5W MT DTT DM0HR5W MA Modulator DM0HR5W RN BMY 14802, a sigma receptor ligand for the treatment of schizophrenia. Neuropsychopharmacology. 1994 Feb;10(1):37-40. DM0HR5W RU https://www.ncbi.nlm.nih.gov/pubmed/7910021 DM0HR5W DI DM0HR5W DM0HR5W DN BMS-181100 DM0HR5W MI TT5TPI6 DM0HR5W MN Opioid receptor sigma 1 (OPRS1) DM0HR5W MT DTT DM0HR5W MA Modulator DM0HR5W RN BMY 14802, a sigma receptor ligand for the treatment of schizophrenia. Neuropsychopharmacology. 1994 Feb;10(1):37-40. DM0HR5W RU https://www.ncbi.nlm.nih.gov/pubmed/7910021 DMFZNLH DI DMFZNLH DMFZNLH DN BMS-204352 DMFZNLH MI TT1VOHK DMFZNLH MN Potassium channel unspecific (KC) DMFZNLH MT DTT DMFZNLH MA Modulator DMFZNLH RN Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41. DMFZNLH RU https://www.ncbi.nlm.nih.gov/pubmed/15950434 DMZK70E DI DMZK70E DMZK70E DN BN 50730 DMZK70E MI TTQL5VC DMZK70E MN Platelet-activating factor receptor (PTAFR) DMZK70E MT DTT DMZK70E MA Modulator DMZK70E RN Platelet-activating factor antagonist BN 50730 attenuates hypoxic-ischemic brain injury in neonatal rats. Pediatr Res. 2001 Jun;49(6):804-11. DMZK70E RU https://www.ncbi.nlm.nih.gov/pubmed/11385142 DMMT1YQ DI DMMT1YQ DMMT1YQ DN Bropirimine DMMT1YQ MI TTG9CFY DMMT1YQ MN Bacterial Dihydroneopterinaldolase (Bact folB) DMMT1YQ MT DTT DMMT1YQ MA Inhibitor DMMT1YQ RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMMT1YQ RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMMT1YQ DI DMMT1YQ DMMT1YQ DN Bropirimine DMMT1YQ MI DEJGDUW DMMT1YQ MN Cytochrome P450 1A2 (CYP1A2) DMMT1YQ MT DME DMMT1YQ MA Metabolism DMMT1YQ RN Human biotransformation of bropirimine. Characterization of the major bropirimine oxidative metabolites formed in vitro. Drug Metab Dispos. 1998 Oct;26(10):1048-51. DMMT1YQ RU https://www.ncbi.nlm.nih.gov/pubmed/?term=9763414 DMMT1YQ DI DMMT1YQ DMMT1YQ DN Bropirimine DMMT1YQ MI TTV2CN0 DMMT1YQ MN Interferon receptor (IFNR) DMMT1YQ MT DTT DMMT1YQ MA Modulator DMMT1YQ RN Comparison between circulating interferon and drug levels following administration of 2-amino-5-bromo-6-phenyl-4(3H)-pyrimidinone (ABPP) to different animal species. J Interferon Res. 1982;2(3):317-27. DMMT1YQ RU https://pubmed.ncbi.nlm.nih.gov/6182250 DMRA6H5 DI DMRA6H5 DMRA6H5 DN Broxaterol DMRA6H5 MI TT2CJVK DMRA6H5 MN Adrenergic receptor beta-2 (ADRB2) DMRA6H5 MT DTT DMRA6H5 MA Modulator DMRA6H5 RN Broxaterol, a new beta 2-adrenoceptor agonist compared to salbutamol in asthmatics, oral and inhalation treatment. Respiration. 1989;55 Suppl 2:15-9. DMRA6H5 RU https://pubmed.ncbi.nlm.nih.gov/2572036 DM4HGMX DI DM4HGMX DM4HGMX DN CDP571 DM4HGMX MI TTF8CQI DM4HGMX MN Tumor necrosis factor (TNF) DM4HGMX MT DTT DM4HGMX MA Modulator DM4HGMX RN CDP571, a humanized monoclonal antibody to tumour necrosis factor-alpha, for steroid-dependent Crohn's disease: a randomized, double-blind, placebo... Aliment Pharmacol Ther. 2006 Mar 1;23(5):617-28. DM4HGMX RU https://www.ncbi.nlm.nih.gov/pubmed/16480401 DMANMXZ DI DMANMXZ DMANMXZ DN CEFCANEL DALOXATE HYDROCHLORIDE DMANMXZ MI TTJP4SM DMANMXZ MN Bacterial Penicillin binding protein (Bact PBP) DMANMXZ MT DTT DMANMXZ MA Modulator DMANMXZ RN Pharmacokinetics of oral cefcanel daloxate hydrochloride in healthy volunteers and patients with various degrees of impaired renal function. J Antimicrob Chemother. 1994 Feb;33(2):281-8. DMANMXZ RU https://pubmed.ncbi.nlm.nih.gov/8182009 DMEMUQP DI DMEMUQP DMEMUQP DN CEFETECOL DMEMUQP MI TTJP4SM DMEMUQP MN Bacterial Penicillin binding protein (Bact PBP) DMEMUQP MT DTT DMEMUQP MA Modulator DMEMUQP RN Antibacterial activities in vitro and in vivo and pharmacokinetics of cefquinome (HR 111V), a new broad-spectrum cephalosporin. Antimicrob Agents Chemother. 1991 Jan;35(1):14-9. DMEMUQP RU https://pubmed.ncbi.nlm.nih.gov/2014969 DMRYC08 DI DMRYC08 DMRYC08 DN CGP71683A DMRYC08 MI TTY6EWA DMRYC08 MN Neuropeptide Y receptor type 5 (NPY5R) DMRYC08 MT DTT DMRYC08 MA Antagonist DMRYC08 RN Neuropeptide Y-induced enhancement of the evoked release of newly synthesized dopamine in rat striatum: mediation by Y2 receptors. Neuropharmacology. 2007 May;52(6):1396-402. DMRYC08 RU https://pubmed.ncbi.nlm.nih.gov/17382974 DMHSM7I DI DMHSM7I DMHSM7I DN Cilomilast DMHSM7I MI TTV5CGO DMHSM7I MN Phosphodiesterase 4 (PDE4) DMHSM7I MT DTT DMHSM7I MA Inhibitor DMHSM7I RN Emerging drugs for the treatment of chronic obstructive pulmonary disease. Expert Opin Emerg Drugs. 2006 May;11(2):275-91. DMHSM7I RU https://pubmed.ncbi.nlm.nih.gov/16634702 DMHSM7I DI DMHSM7I DMHSM7I DN Cilomilast DMHSM7I MI TTZ97H5 DMHSM7I MN Phosphodiesterase 4A (PDE4A) DMHSM7I MT DTT DMHSM7I MA Inhibitor DMHSM7I RN Emerging drugs for asthma. Expert Opin Emerg Drugs. 2008 Dec;13(4):643-53. DMHSM7I RU https://pubmed.ncbi.nlm.nih.gov/19046132 DMOU173 DI DMOU173 DMOU173 DN CP-945598 DMOU173 MI TT6OEDT DMOU173 MN Cannabinoid receptor 1 (CB1) DMOU173 MT DTT DMOU173 MA Antagonist DMOU173 RN Pfizer. Product Development Pipeline. March 31 2009. DMOU173 RU http://media.pfizer.com/files/research/pipeline/2009_0331/pipeline_2009_0331.pdf DM753RT DI DM753RT DM753RT DN CVT-124 DM753RT MI TTK25J1 DM753RT MN Adenosine A1 receptor (ADORA1) DM753RT MT DTT DM753RT MA Antagonist DM753RT RN CV Therapeutics. Company report from CV Therapeutics, Inc. CV Therapeutics. 2009. DM753RT RU http://www.prnewswire.com/cgi-bin/stories.pl?ACCT=104&STORY=/www/story/11-08-2007/0004700893&EDATE= DMHSLVO DI DMHSLVO DMHSLVO DN DA-7101 DMHSLVO MI TTHI19T DMHSLVO MN Staphylococcus Beta-lactamase (Stap-coc blaZ) DMHSLVO MT DTT DMHSLVO MA Inhibitor DMHSLVO RN Emerging drugs for bacterial urinary tract infections. Expert Opin Emerg Drugs. 2005 May;10(2):275-98. DMHSLVO RU https://pubmed.ncbi.nlm.nih.gov/15934867 DMNQIKV DI DMNQIKV DMNQIKV DN DALTROBAN DMNQIKV MI TT2O84V DMNQIKV MN Thromboxane A2 receptor (TBXA2R) DMNQIKV MT DTT DMNQIKV MA Inhibitor DMNQIKV RN Synthesis and thromboxane A2/prostaglandin H2 receptor antagonistic activity of phenol derivatives. J Med Chem. 1992 Jun 12;35(12):2202-9. DMNQIKV RU https://pubmed.ncbi.nlm.nih.gov/1535377 DMZ38EN DI DMZ38EN DMZ38EN DN Dalvastatin DMZ38EN MI TTPADOQ DMZ38EN MN HMG-CoA reductase (HMGCR) DMZ38EN MT DTT DMZ38EN MA Inhibitor DMZ38EN RN RG 12561 (dalvastatin): a novel synthetic inhibitor of HMG-CoA reductase and cholesterol-lowering agent. Pharmacology. 1993;46(1):13-22. DMZ38EN RU https://pubmed.ncbi.nlm.nih.gov/8434028 DMSWLA3 DI DMSWLA3 DMSWLA3 DN Darapladib DMSWLA3 MI TT9V5JH DMSWLA3 MN Phospholipase A2 (PLA2G1B) DMSWLA3 MT DTT DMSWLA3 MA Modulator DMSWLA3 RN Darapladib, a reversible lipoprotein-associated phospholipase A2 inhibitor, for the oral treatment of atherosclerosis and coronary artery disease. IDrugs. 2009 Oct;12(10):648-55. DMSWLA3 RU https://www.ncbi.nlm.nih.gov/pubmed/19790016 DMC40SD DI DMC40SD DMC40SD DN Darexaban maleate DMC40SD MI TTCIHJA DMC40SD MN Coagulation factor Xa (F10) DMC40SD MT DTT DMC40SD MA Inhibitor DMC40SD RN The pharmacokinetics of darexaban are not affected to a clinically relevant degree by rifampicin, a strong inducer of P-glycoprotein and CYP3A4. Br J Clin Pharmacol. 2013 Feb;75(2):440-9. DMC40SD RU https://pubmed.ncbi.nlm.nih.gov/22642721 DMEMF60 DI DMEMF60 DMEMF60 DN Delequamine hydrochloride DMEMF60 MI TT2NUT5 DMEMF60 MN Adrenergic receptor alpha-2C (ADRA2C) DMEMF60 MT DTT DMEMF60 MA Modulator DMEMF60 RN Modulation of sexual behaviour in the rat by a potent and selective alpha 2-adrenoceptor antagonist, delequamine (RS-15385-197). Br J Pharmacol. 1996 May;118(1):63-72. DMEMF60 RU https://pubmed.ncbi.nlm.nih.gov/8733577 DMXKWAL DI DMXKWAL DMXKWAL DN Deligoparin sodium DMXKWAL MI TT4QPUL DMXKWAL MN Antithrombin-III (ATIII) DMXKWAL MT DTT DMXKWAL MA Modulator DMXKWAL RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2632). DMXKWAL RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2632 DM8DUZT DI DM8DUZT DM8DUZT DN Deramciclane DM8DUZT MI TTJQOD7 DM8DUZT MN 5-HT 2A receptor (HTR2A) DM8DUZT MT DTT DM8DUZT MA Modulator DM8DUZT RN Deramciclane, a putative anxiolytic drug, is a serotonin 5-HT2C receptor inverse agonist but fails to induce 5-HT2C receptor down-regulation. Psychopharmacology (Berl). 1998 Mar;136(2):99-104. DM8DUZT RU https://pubmed.ncbi.nlm.nih.gov/9551765 DM8DUZT DI DM8DUZT DM8DUZT DN Deramciclane DM8DUZT MI TTWJBZ5 DM8DUZT MN 5-HT 2C receptor (HTR2C) DM8DUZT MT DTT DM8DUZT MA Modulator DM8DUZT RN Deramciclane, a putative anxiolytic drug, is a serotonin 5-HT2C receptor inverse agonist but fails to induce 5-HT2C receptor down-regulation. Psychopharmacology (Berl). 1998 Mar;136(2):99-104. DM8DUZT RU https://pubmed.ncbi.nlm.nih.gov/9551765 DM8DUZT DI DM8DUZT DM8DUZT DN Deramciclane DM8DUZT MI DEVDYN7 DM8DUZT MN Cytochrome P450 2E1 (CYP2E1) DM8DUZT MT DME DM8DUZT MA Metabolism DM8DUZT RN Role of CYP2E1 in deramciclane metabolism. Drug Metab Dispos. 2005 Nov;33(11):1717-22. DM8DUZT RU https://www.ncbi.nlm.nih.gov/pubmed/?term=15932955 DMO3AJS DI DMO3AJS DMO3AJS DN DG031 DMO3AJS MI TTDMBF5 DMO3AJS MN Arachidonate 5-lipoxygenase activating protein (FLAP) DMO3AJS MT DTT DMO3AJS MA Inhibitor DMO3AJS RN BAY x 1005 attenuates atherosclerosis in apoE/LDLR - double knockout mice. J Physiol Pharmacol. 2007 Sep;58(3):583-8. DMO3AJS RU https://pubmed.ncbi.nlm.nih.gov/17928652 DMX2SHT DI DMX2SHT DMX2SHT DN Dianicline DMX2SHT MI TTL1ATN DMX2SHT MN Neuronal acetylcholine receptor alpha-4/beta-2 (CHRNA4/B2) DMX2SHT MT DTT DMX2SHT MA Modulator DMX2SHT RN Dianicline, a novel 42 nicotinic acetylcholine receptor partial agonist, for smoking cessation: a randomized placebo-controlled clinical trial.Nicotine Tob Res.2011 Jan;13(1):1-6. DMX2SHT RU https://www.ncbi.nlm.nih.gov/pubmed/21041839 DMWMHU7 DI DMWMHU7 DMWMHU7 DN Dofequidar fumarate DMWMHU7 MI TTJUXV6 DMWMHU7 MN Multidrug resistance protein 3 (ABCB4) DMWMHU7 MT DTT DMWMHU7 MA Modulator DMWMHU7 RN Reversal of multidrug resistance by a novel quinoline derivative, MS-209. Cancer Chemother Pharmacol. 1995;35(4):271-7. DMWMHU7 RU https://pubmed.ncbi.nlm.nih.gov/7828268 DMJOM31 DI DMJOM31 DMJOM31 DN ELGODIPINE HYDROCHLORIDE DMJOM31 MI TT5HONZ DMJOM31 MN Calcium channel unspecific (CaC) DMJOM31 MT DTT DMJOM31 MA Agonist DMJOM31 RN The calcium channel blocker amlodipine exerts its anti-proliferative action via p21(Waf1/Cip1) gene activation. FASEB J. 2004 Oct;18(13):1516-23. DMJOM31 RU https://pubmed.ncbi.nlm.nih.gov/15466360 DM38CIV DI DM38CIV DM38CIV DN ELTANOLONE DM38CIV MI TT1MPAY DM38CIV MN GABA(A) receptor alpha-1 (GABRA1) DM38CIV MT DTT DM38CIV MA Inhibitor DM38CIV RN Neurosteroid analogues. 10. The effect of methyl group substitution at the C-6 and C-7 positions on the GABA modulatory and anesthetic actions of (... J Med Chem. 2005 Apr 21;48(8):3051-9. DM38CIV RU https://pubmed.ncbi.nlm.nih.gov/15828844 DM38CIV DI DM38CIV DM38CIV DN ELTANOLONE DM38CIV MI TTZA1NY DM38CIV MN GABA(A) receptor beta-2 (GABRB2) DM38CIV MT DTT DM38CIV MA Inhibitor DM38CIV RN Neurosteroid analogues. 10. The effect of methyl group substitution at the C-6 and C-7 positions on the GABA modulatory and anesthetic actions of (... J Med Chem. 2005 Apr 21;48(8):3051-9. DM38CIV RU https://pubmed.ncbi.nlm.nih.gov/15828844 DM38CIV DI DM38CIV DM38CIV DN ELTANOLONE DM38CIV MI TT06RH5 DM38CIV MN GABA(A) receptor gamma-2 (GABRG2) DM38CIV MT DTT DM38CIV MA Inhibitor DM38CIV RN Neurosteroid analogues. 10. The effect of methyl group substitution at the C-6 and C-7 positions on the GABA modulatory and anesthetic actions of (... J Med Chem. 2005 Apr 21;48(8):3051-9. DM38CIV RU https://pubmed.ncbi.nlm.nih.gov/15828844 DM38CIV DI DM38CIV DM38CIV DN ELTANOLONE DM38CIV MI TTNJYV2 DM38CIV MN Gamma-aminobutyric acid receptor (GAR) DM38CIV MT DTT DM38CIV MA Inhibitor DM38CIV RN Neurosteroid analogues. 11. Alternative ring system scaffolds: gamma-aminobutyric acid receptor modulation and anesthetic actions of benz[f]indenes. J Med Chem. 2006 Jul 27;49(15):4595-605. DM38CIV RU https://pubmed.ncbi.nlm.nih.gov/16854065 DM5JUW0 DI DM5JUW0 DM5JUW0 DN EM-800 DM5JUW0 MI TTZAYWL DM5JUW0 MN Estrogen receptor (ESR) DM5JUW0 MT DTT DM5JUW0 MA Antagonist DM5JUW0 RN EM-800, a novel antiestrogen, acts as a pure antagonist of the transcriptional functions of estrogen receptors alpha and beta. Endocrinology. 1998 Jan;139(1):111-8. DM5JUW0 RU https://pubmed.ncbi.nlm.nih.gov/9421405 DM5JUW0 DI DM5JUW0 DM5JUW0 DN EM-800 DM5JUW0 MI TTOM3J0 DM5JUW0 MN Estrogen receptor beta (ESR2) DM5JUW0 MT DTT DM5JUW0 MA Antagonist DM5JUW0 RN EM-800, a novel antiestrogen, acts as a pure antagonist of the transcriptional functions of estrogen receptors alpha and beta. Endocrinology. 1998 Jan;139(1):111-8. DM5JUW0 RU https://pubmed.ncbi.nlm.nih.gov/9421405 DMCU1WO DI DMCU1WO DMCU1WO DN Eperezolid DMCU1WO MI TTUWYEA DMCU1WO MN Bacterial 50S ribosomal RNA (Bact 50S rRNA) DMCU1WO MT DTT DMCU1WO MA Modulator DMCU1WO RN The oxazolidinone eperezolid binds to the 50S ribosomal subunit and competes with binding of chloramphenicol and lincomycin. DMCU1WO RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC164081 DMM5ZX6 DI DMM5ZX6 DMM5ZX6 DN Epothilone B DMM5ZX6 MI DE4LYSA DMM5ZX6 MN Cytochrome P450 3A4 (CYP3A4) DMM5ZX6 MT DME DMM5ZX6 MA Metabolism DMM5ZX6 RN The effect of ketoconazole on the pharmacokinetics and pharmacodynamics of ixabepilone: a first in class epothilone B analogue in late-phase clinical development. Clin Cancer Res. 2008 May 1;14(9):2701-9. DMM5ZX6 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=18451235 DMM5ZX6 DI DMM5ZX6 DMM5ZX6 DN Epothilone B DMM5ZX6 MI TTML2WA DMM5ZX6 MN Tubulin (TUB) DMM5ZX6 MT DTT DMM5ZX6 MA Inhibitor DMM5ZX6 RN Emerging therapies for multiple myeloma. Expert Opin Emerg Drugs. 2009 Mar;14(1):99-127. DMM5ZX6 RU https://pubmed.ncbi.nlm.nih.gov/19249983 DM3OUT0 DI DM3OUT0 DM3OUT0 DN Etarotene DM3OUT0 MI TT4PTJ7 DM3OUT0 MN Ribonuclease P protein (RPP) DM3OUT0 MT DTT DM3OUT0 MA Modulator DM3OUT0 RN Retinoids inhibit human epidermal keratinocyte RNase P activity. Biol Chem. 2003 Mar;384(3):457-62. DM3OUT0 RU https://pubmed.ncbi.nlm.nih.gov/12715896 DMF93U1 DI DMF93U1 DMF93U1 DN Etilevodopa DMF93U1 MI DECB0K3 DMF93U1 MN Cytochrome P450 2D6 (CYP2D6) DMF93U1 MT DME DMF93U1 MA Metabolism DMF93U1 RN Identification of cytochrome P450 enzymes involved in the metabolism of 4'-methoxy-alpha-pyrrolidinopropiophenone (MOPPP), a designer drug, in human liver microsomes. Xenobiotica. 2003 Oct;33(10):989-98. DMF93U1 RU http://www.ncbi.nlm.nih.gov/pubmed/14555336 DM159U2 DI DM159U2 DM159U2 DN Evernimicin DM159U2 MI TTUWYEA DM159U2 MN Bacterial 50S ribosomal RNA (Bact 50S rRNA) DM159U2 MT DTT DM159U2 MA Modulator DM159U2 RN Evernimicin binds exclusively to the 50S ribosomal subunit and inhibits translation in cell-free systems derived from both gram-positive and gram-n... Antimicrob Agents Chemother. 2000 May;44(5):1121-6. DM159U2 RU https://www.ncbi.nlm.nih.gov/pubmed/10770739 DMOIP7R DI DMOIP7R DMOIP7R DN Flesinoxan DMOIP7R MI TTSQIFT DMOIP7R MN 5-HT 1A receptor (HTR1A) DMOIP7R MT DTT DMOIP7R MA Agonist DMOIP7R RN Effect of sustained administration of the 5-HT1A receptor agonist flesinoxan on rat 5-HT neurotransmission. Eur Neuropsychopharmacol. 1999 Sep;9(5):427-40. DMOIP7R RU https://pubmed.ncbi.nlm.nih.gov/10523050 DMOIP7R DI DMOIP7R DMOIP7R DN Flesinoxan DMOIP7R MI DTUGYRD DMOIP7R MN P-glycoprotein 1 (ABCB1) DMOIP7R MT DTP DMOIP7R MA Substrate DMOIP7R RN Active efflux of the 5-HT(1A) receptor agonist flesinoxan via P-glycoprotein at the blood-brain barrier. Eur J Pharm Sci. 2001 Aug;14(1):81-6. DMOIP7R RU https://doi.org/10.1016/S0928-0987(01)00150-6 DMN1O7E DI DMN1O7E DMN1O7E DN FLUPAROXAN DMN1O7E MI TT2NUT5 DMN1O7E MN Adrenergic receptor alpha-2C (ADRA2C) DMN1O7E MT DTT DMN1O7E MA Modulator DMN1O7E RN The pharmacology of fluparoxan: a selective alpha 2-adrenoceptor antagonist. Br J Pharmacol. 1991 Apr;102(4):887-95. DMN1O7E RU https://pubmed.ncbi.nlm.nih.gov/1677298 DML1DGP DI DML1DGP DML1DGP DN FOROPAFANT DML1DGP MI TTQL5VC DML1DGP MN Platelet-activating factor receptor (PTAFR) DML1DGP MT DTT DML1DGP MA Antagonist DML1DGP RN Biochemical and pharmacological activities of SR 27417, a highly potent, long-acting platelet-activating factor receptor antagonist. J Pharmacol Exp Ther. 1991 Oct;259(1):44-51. DML1DGP RU https://pubmed.ncbi.nlm.nih.gov/1656029 DME94QF DI DME94QF DME94QF DN Furnidipine DME94QF MI TTXHYV6 DME94QF MN Voltage-gated L-type calcium channel (L-CaC) DME94QF MT DTT DME94QF MA Modulator DME94QF RN Q-type Ca2+ channels are located closer to secretory sites than L-type channels: functional evidence in chromaffin cells. Pflugers Arch. 1998 Mar;435(4):472-8. DME94QF RU https://www.ncbi.nlm.nih.gov/pubmed/9446693 DMNSE2I DI DMNSE2I DMNSE2I DN Galocitabine DMNSE2I MI TTU6BFZ DMNSE2I MN Candida Thymidylate synthase (Candi TMP1) DMNSE2I MT DTT DMNSE2I MA Inhibitor DMNSE2I RN The role of thymidylate synthase in cellular regulation. Adv Enzyme Regul. 1996;36:143-63. DMNSE2I RU https://pubmed.ncbi.nlm.nih.gov/8869745 DMJ4KQS DI DMJ4KQS DMJ4KQS DN GW-406381 DMJ4KQS MI TTVKILB DMJ4KQS MN Prostaglandin G/H synthase 2 (COX-2) DMJ4KQS MT DTT DMJ4KQS MA Inhibitor DMJ4KQS RN Emerging drugs in neuropathic pain. Expert Opin Emerg Drugs. 2007 Mar;12(1):113-26. DMJ4KQS RU https://pubmed.ncbi.nlm.nih.gov/17355217 DMG6TS2 DI DMG6TS2 DMG6TS2 DN GW873140 DMG6TS2 MI TT2CEJG DMG6TS2 MN C-C chemokine receptor type 5 (CCR5) DMG6TS2 MT DTT DMG6TS2 MA Binder DMG6TS2 RN In vitro and clinical investigation of the relationship between CCR5 receptor occupancy and anti-HIV activity of Aplaviroc. J Clin Pharmacol. 2008 Oct;48(10):1179-88. DMG6TS2 RU https://pubmed.ncbi.nlm.nih.gov/18676693 DMG6TS2 DI DMG6TS2 DMG6TS2 DN GW873140 DMG6TS2 MI DE4LYSA DMG6TS2 MN Cytochrome P450 3A4 (CYP3A4) DMG6TS2 MT DME DMG6TS2 MA Metabolism DMG6TS2 RN Hepatotoxicity observed in clinical trials of aplaviroc (GW873140). Antimicrob Agents Chemother. 2008 Mar;52(3):858-65. DMG6TS2 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=18070967 DMG6TS2 DI DMG6TS2 DMG6TS2 DN GW873140 DMG6TS2 MI DEGTFWK DMG6TS2 MN Mephenytoin 4-hydroxylase (CYP2C19) DMG6TS2 MT DME DMG6TS2 MA Metabolism DMG6TS2 RN Hepatotoxicity observed in clinical trials of aplaviroc (GW873140). Antimicrob Agents Chemother. 2008 Mar;52(3):858-65. DMG6TS2 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=18070967 DMWB23S DI DMWB23S DMWB23S DN H1N1 influenza vaccine DMWB23S MI TT3J5ZI DMWB23S MN Cell mediated immunity response (CMIR) DMWB23S MT DTT DMWB23S RN Risk factors affecting seroconversion after influenza A/H1N1 vaccination in hemodialysis patients. BMC Nephrol. 2012 Dec 3;13:165. DMWB23S RU https://pubmed.ncbi.nlm.nih.gov/23206898 DMX3IRE DI DMX3IRE DMX3IRE DN HBP-347 DMX3IRE MI TT78R5H DMX3IRE MN Heat shock protein 90 alpha (HSP90A) DMX3IRE MT DTT DMX3IRE MA Modulator DMX3IRE RN US patent application no. 2013,0023,420, Susceptibility to hsp90-inhibitors. DMX3IRE RU http://www.google.com/patents/US20130023420 DMGYKDN DI DMGYKDN DMGYKDN DN Hemoximer DMGYKDN MI TTQO71U DMGYKDN MN Hemoglobin (HB) DMGYKDN MT DTT DMGYKDN MA Antagonist DMGYKDN RN Effect of NaBH4 Concentration and Reaction Time on Physical Properties of Glutaraldehyde-Polymerized Hemoglobin. Biotechnology Progress. 05/2004; 20(3):946-52. DMGYKDN RU http://onlinelibrary.wiley.com/doi/10.1021/bp0499754/abstract DMRXUY7 DI DMRXUY7 DMRXUY7 DN Idoxifene DMRXUY7 MI TTZAYWL DMRXUY7 MN Estrogen receptor (ESR) DMRXUY7 MT DTT DMRXUY7 MA Modulator DMRXUY7 RN Idoxifene: a novel selective estrogen receptor modulator prevents bone loss and lowers cholesterol levels in ovariectomized rats and decreases uterine weight in intact rats. Endocrinology. 1998 Dec;139(12):5224-34. DMRXUY7 RU https://pubmed.ncbi.nlm.nih.gov/9832463 DM3SKAC DI DM3SKAC DM3SKAC DN Idraparinux DM3SKAC MI TTCIHJA DM3SKAC MN Coagulation factor Xa (F10) DM3SKAC MT DTT DM3SKAC MA Inhibitor DM3SKAC RN Pharma & Vaccines. Product Development Pipeline. April 29 2009. DM3SKAC RU http://en.sanofi-aventis.com/binaries/RD_Phase_III_EN_tcm28-24007.pdf DMDEL2W DI DMDEL2W DMDEL2W DN Iferanserin-Ventrus DMDEL2W MI TTJQOD7 DMDEL2W MN 5-HT 2A receptor (HTR2A) DMDEL2W MT DTT DMDEL2W MA Modulator DMDEL2W RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 6). DMDEL2W RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=6 DM8KSMX DI DM8KSMX DM8KSMX DN IMIRESTAT DM8KSMX MI TTFBNVI DM8KSMX MN Aldose reductase (AKR1B1) DM8KSMX MT DTT DM8KSMX MA Inhibitor DM8KSMX RN Spiro[fluoreneisothiazolidin]one dioxides: new aldose reductase and L-hexonate dehydrogenase inhibitors. J Med Chem. 1991 Nov;34(11):3229-34. DM8KSMX RU https://pubmed.ncbi.nlm.nih.gov/1956041 DMTHMEI DI DMTHMEI DMTHMEI DN INS 316 DMTHMEI MI TTYXPCO DMTHMEI MN P2Y purinoceptor 11 (P2RY11) DMTHMEI MT DTT DMTHMEI MA Agonist DMTHMEI RN Characterization of a Ca2+ response to both UTP and ATP at human P2Y11 receptors: evidence for agonist-specific signaling. Mol Pharmacol. 2003 Jun;63(6):1356-63. DMTHMEI RU https://pubmed.ncbi.nlm.nih.gov/12761346 DMTHMEI DI DMTHMEI DMTHMEI DN INS 316 DMTHMEI MI TTOZHQC DMTHMEI MN P2Y purinoceptor 2 (P2RY2) DMTHMEI MT DTT DMTHMEI MA Modulator DMTHMEI RN Safety of aerosolized INS 365 in patients with mild to moderate cystic fibrosis: results of a phase I multi-center study. Pediatr Pulmonol. 2001 Aug;32(2):122-8. DMTHMEI RU https://pubmed.ncbi.nlm.nih.gov/11477729 DMTHMEI DI DMTHMEI DMTHMEI DN INS 316 DMTHMEI MI TT24DGP DMTHMEI MN P2Y purinoceptor 4 (P2RY4) DMTHMEI MT DTT DMTHMEI MA Agonist DMTHMEI RN ATP, an agonist at the rat P2Y(4) receptor, is an antagonist at the human P2Y(4) receptor. Mol Pharmacol. 2000 May;57(5):926-31. DMTHMEI RU https://pubmed.ncbi.nlm.nih.gov/10779375 DMTHMEI DI DMTHMEI DMTHMEI DN INS 316 DMTHMEI MI TTNVSKA DMTHMEI MN P2Y purinoceptor 6 (P2RY6) DMTHMEI MT DTT DMTHMEI MA Agonist DMTHMEI RN Cloning, functional expression and tissue distribution of the human P2Y6 receptor. Biochem Biophys Res Commun. 1996 May 15;222(2):303-8. DMTHMEI RU https://pubmed.ncbi.nlm.nih.gov/8670200 DMVL8PB DI DMVL8PB DMVL8PB DN IoGen DMVL8PB MI TTZAYWL DMVL8PB MN Estrogen receptor (ESR) DMVL8PB MT DTT DMVL8PB MA Modulator DMVL8PB RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 620). DMVL8PB RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=620 DM7SA9J DI DM7SA9J DM7SA9J DN IR-103 DM7SA9J MI TTSHG0T DM7SA9J MN Toll-like receptor 9 (TLR9) DM7SA9J MT DTT DM7SA9J RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1759). DM7SA9J RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1759 DMUYQH8 DI DMUYQH8 DMUYQH8 DN IRX-4310 DMUYQH8 MI TTOD7B3 DMUYQH8 MN Retinoic acid receptor (RAR) DMUYQH8 MT DTT DMUYQH8 MA Antagonist DMUYQH8 RN An antagonist of retinoic acid receptors more effectively inhibits growth of human prostate cancer cells than normal prostate epithelium. Br J Cancer. 2004 Aug 2;91(3):580-8. DMUYQH8 RU https://pubmed.ncbi.nlm.nih.gov/15266311 DM1AFPW DI DM1AFPW DM1AFPW DN KC-764 DM1AFPW MI TTK0943 DM1AFPW MN Prostaglandin G/H synthase (COX) DM1AFPW MT DTT DM1AFPW MA Modulator DM1AFPW RN Clinical and preclinical pharmacology of KC-764, a novel antiplatelet agent. Nihon Rinsho. 1992 Feb;50(2):379-84. DM1AFPW RU https://pubmed.ncbi.nlm.nih.gov/1613994 DMZMFX6 DI DMZMFX6 DMZMFX6 DN KU-1257 DMZMFX6 MI TTQHJ1K DMZMFX6 MN Histamine H2 receptor (H2R) DMZMFX6 MT DTT DMZMFX6 MA Antagonist DMZMFX6 RN Pharmacological profiles of the new histamine H2-receptor antagonist N-ethyl-N'-[3-[3-(piperidinomethyl)phenoxy] propyl] urea. Arzneimittelforschung. 1993 Feb;43(2):129-33. DMZMFX6 RU https://pubmed.ncbi.nlm.nih.gov/8096132 DMQZ6SE DI DMQZ6SE DMQZ6SE DN KW-2149 DMQZ6SE MI TTUTN1I DMQZ6SE MN Human Deoxyribonucleic acid (hDNA) DMQZ6SE MT DTT DMQZ6SE MA Binder DMQZ6SE RN KW-2149 (7-N-[2-[gamma-L-glutamylamino]ethyldithioethyl] mitomycin C): DNA interactions and drug uptake following serum activation. Biochem Pharmacol. 1998 Jun 1;55(11):1777-83. DMQZ6SE RU https://pubmed.ncbi.nlm.nih.gov/9714295 DMXWRGF DI DMXWRGF DMXWRGF DN L-759274 DMXWRGF MI TTZPO1L DMXWRGF MN Substance-P receptor (TACR1) DMXWRGF MT DTT DMXWRGF MA Antagonist DMXWRGF RN Novel drugs and therapeutic targets for severe mood disorders. Neuropsychopharmacology. 2008 Aug;33(9):2080-92. DMXWRGF RU https://pubmed.ncbi.nlm.nih.gov/18172433 DM7RGFW DI DM7RGFW DM7RGFW DN Lamectacin DM7RGFW MI TTEX248 DM7RGFW MN Dopamine D2 receptor (D2R) DM7RGFW MT DTT DM7RGFW MA Antagonist DM7RGFW RN Emerging drugs for bipolar disorder. Expert Opin Emerg Drugs. 2006 Nov;11(4):621-34. DM7RGFW RU https://pubmed.ncbi.nlm.nih.gov/17064222 DMHR1A7 DI DMHR1A7 DMHR1A7 DN LAMIFIBAN DMHR1A7 MI TT38RM1 DMHR1A7 MN Glycoprotein IIb/IIIa receptor (GPIIb/IIIa) DMHR1A7 MT DTT DMHR1A7 MA Modulator DMHR1A7 RN Lamifiban. Drugs. 1999 Feb;57(2):215-21; discussion 222-3. DMHR1A7 RU https://www.ncbi.nlm.nih.gov/pubmed/10188762 DMJY9CW DI DMJY9CW DMJY9CW DN Lapaquistat acetate DMJY9CW MI TTFQEO5 DMJY9CW MN Squalene synthetase (FDFT1) DMJY9CW MT DTT DMJY9CW MA Inhibitor DMJY9CW RN Lapaquistat acetate, a squalene synthase inhibitor, changes macrophage/lipid-rich coronary plaques of hypercholesterolaemic rabbits into fibrous le... Br J Pharmacol. 2008 Jul;154(5):949-57. DMJY9CW RU https://pubmed.ncbi.nlm.nih.gov/18587443 DM8CEDR DI DM8CEDR DM8CEDR DN Laropiprant+niacin DM8CEDR MI TTNVEIR DM8CEDR MN Prostaglandin D2 receptor (PTGDR) DM8CEDR MT DTT DM8CEDR MA Antagonist DM8CEDR RN Emerging antidyslipidemic drugs. Expert Opin Emerg Drugs. 2008 Jun;13(2):363-81. DM8CEDR RU https://pubmed.ncbi.nlm.nih.gov/18537526 DMCM239 DI DMCM239 DMCM239 DN Larotaxel DMCM239 MI TTML2WA DMCM239 MN Tubulin (TUB) DMCM239 MT DTT DMCM239 MA Inhibitor DMCM239 RN Pharma & Vaccines. Product Development Pipeline. April 29 2009. DMCM239 RU http://en.sanofi-aventis.com/binaries/RD_Phase_III_EN_tcm28-24007.pdf DMKMTR7 DI DMKMTR7 DMKMTR7 DN LDI-200 DMKMTR7 MI TT2O4W9 DMKMTR7 MN Luteinizing hormone receptor (LHCGR) DMKMTR7 MT DTT DMKMTR7 MA Modulator DMKMTR7 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 254). DMKMTR7 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=254 DMN9KJ2 DI DMN9KJ2 DMN9KJ2 DN Lenercept DMN9KJ2 MI TTZXH48 DMN9KJ2 MN TNF receptor (TNFR) DMN9KJ2 MT DTT DMN9KJ2 MA Modulator DMN9KJ2 RN Lenercept (p55 tumor necrosis factor receptor fusion protein) in severe sepsis and early septic shock: a randomized, double-blind, placebo-controll... Crit Care Med. 2001 Mar;29(3):503-10. DMN9KJ2 RU https://www.ncbi.nlm.nih.gov/pubmed/11373411 DMWUS8N DI DMWUS8N DMWUS8N DN Licarbazepine DMWUS8N MI TTRK8B9 DMWUS8N MN Sodium channel unspecific (NaC) DMWUS8N MT DTT DMWUS8N MA Blocker DMWUS8N RN Emerging drugs for bipolar disorder. Expert Opin Emerg Drugs. 2006 Nov;11(4):621-34. DMWUS8N RU https://pubmed.ncbi.nlm.nih.gov/17064222 DM8OMI6 DI DM8OMI6 DM8OMI6 DN Lobucavir DM8OMI6 MI TT84ETX DM8OMI6 MN Human immunodeficiency virus Reverse transcriptase (HIV RT) DM8OMI6 MT DTT DM8OMI6 MA Modulator DM8OMI6 RN Antiviral efficacy of lobucavir (BMS-180194), a cyclobutyl-guanosine nucleoside analogue, in the woodchuck (Marmota monax) model of chronic hepatit... Antiviral Res. 2000 Dec;48(3):197-203. DM8OMI6 RU https://www.ncbi.nlm.nih.gov/pubmed/11164506 DMHE804 DI DMHE804 DMHE804 DN LOTRAFIBAN DMHE804 MI TT38RM1 DMHE804 MN Glycoprotein IIb/IIIa receptor (GPIIb/IIIa) DMHE804 MT DTT DMHE804 MA Modulator DMHE804 RN Lotrafiban: an oral platelet glycoprotein IIb/IIIa blocker.Expert Opin Investig Drugs.2000 Nov;9(11):2673-87. DMHE804 RU https://www.ncbi.nlm.nih.gov/pubmed/11060829 DM2KITF DI DM2KITF DM2KITF DN LY335979 DM2KITF MI TT3OT40 DM2KITF MN Multidrug resistance protein 1 (ABCB1) DM2KITF MT DTT DM2KITF MA Modulator DM2KITF RN A Phase I trial of a potent P-glycoprotein inhibitor, zosuquidar trihydrochloride (LY335979), administered intravenously in combination with doxoru... Clin Cancer Res. 2004 May 15;10(10):3265-72. DM2KITF RU https://www.ncbi.nlm.nih.gov/pubmed/15161679 DM2KITF DI DM2KITF DM2KITF DN LY335979 DM2KITF MI TTJUXV6 DM2KITF MN Multidrug resistance protein 3 (ABCB4) DM2KITF MT DTT DM2KITF MA Modulator DM2KITF RN A Phase I trial of a potent P-glycoprotein inhibitor, zosuquidar trihydrochloride (LY335979), administered intravenously in combination with doxoru... Clin Cancer Res. 2004 May 15;10(10):3265-72. DM2KITF RU https://www.ncbi.nlm.nih.gov/pubmed/15161679 DMSC4K1 DI DMSC4K1 DMSC4K1 DN LY-544344 DMSC4K1 MI TTXJ47W DMSC4K1 MN Metabotropic glutamate receptor 2 (mGluR2) DMSC4K1 MT DTT DMSC4K1 MA Agonist DMSC4K1 RN Glutamate- and GABA-based CNS therapeutics. Curr Opin Pharmacol. 2006 Feb;6(1):7-17. DMSC4K1 RU https://pubmed.ncbi.nlm.nih.gov/16377242 DMSC4K1 DI DMSC4K1 DMSC4K1 DN LY-544344 DMSC4K1 MI TT8A9EF DMSC4K1 MN Metabotropic glutamate receptor 3 (mGluR3) DMSC4K1 MT DTT DMSC4K1 MA Agonist DMSC4K1 RN Glutamate- and GABA-based CNS therapeutics. Curr Opin Pharmacol. 2006 Feb;6(1):7-17. DMSC4K1 RU https://pubmed.ncbi.nlm.nih.gov/16377242 DMUR3VP DI DMUR3VP DMUR3VP DN MDL-11939 DMUR3VP MI TTJQOD7 DMUR3VP MN 5-HT 2A receptor (HTR2A) DMUR3VP MT DTT DMUR3VP MA Inhibitor DMUR3VP RN Ketanserin analogues: structure-affinity relationships for 5-HT2 and 5-HT1C serotonin receptor binding. J Med Chem. 1992 Dec 25;35(26):4903-10. DMUR3VP RU https://pubmed.ncbi.nlm.nih.gov/1479590 DMAZ28C DI DMAZ28C DMAZ28C DN Metazosin DMAZ28C MI TTG28O6 DMAZ28C MN Adrenergic receptor Alpha-1 (ADRA1) DMAZ28C MT DTT DMAZ28C MA Antagonist DMAZ28C RN Metazosin tablets (Kenosin) in the treatment of chronic congestive heart failure. Cas Lek Cesk. 1995 Sep 20;134(18):590-3. DMAZ28C RU https://pubmed.ncbi.nlm.nih.gov/7489576 DM9FJ7N DI DM9FJ7N DM9FJ7N DN Midafotel DM9FJ7N MI TT9IK2Z DM9FJ7N MN N-methyl-D-aspartate receptor (NMDAR) DM9FJ7N MT DTT DM9FJ7N MA Modulator DM9FJ7N RN D-CPP-ene (SDZ EAA 494), a potent and competitive N-methyl-D-aspartate (NMDA) antagonist: effect on spontaneous activity and NMDA-induced depolarizations in the rat neocortical slice preparation, compared with other CPP derivatives and MK-801. Neurosci Lett. 1990 Jun 8;113(3):315-21. DM9FJ7N RU https://pubmed.ncbi.nlm.nih.gov/2166255 DMPCY8K DI DMPCY8K DMPCY8K DN Milameline DMPCY8K MI TTOXS3C DMPCY8K MN Muscarinic acetylcholine receptor (CHRM) DMPCY8K MT DTT DMPCY8K MA Modulator DMPCY8K RN Milameline (CI-979/RU35926): a muscarinic receptor agonist with cognition-activating properties: biochemical and in vivo characterization. J Pharmacol Exp Ther. 1999 Nov;291(2):812-22. DMPCY8K RU https://pubmed.ncbi.nlm.nih.gov/10525104 DM86XJG DI DM86XJG DM86XJG DN MINALRESTAT DM86XJG MI TTFBNVI DM86XJG MN Aldose reductase (AKR1B1) DM86XJG MT DTT DM86XJG MA Modulator DM86XJG RN Minalrestat, an aldose reductase inhibitor, corrects the impaired microvascular reactivity in diabetes. J Pharmacol Exp Ther. 2003 Mar;304(3):1236-42. DM86XJG RU https://www.ncbi.nlm.nih.gov/pubmed/12604701 DMMZO8X DI DMMZO8X DMMZO8X DN Miproxifene DMMZO8X MI TTZAYWL DMMZO8X MN Estrogen receptor (ESR) DMMZO8X MT DTT DMMZO8X MA Modulator DMMZO8X RN Estrogen agonistic/antagonistic effects of miproxifene phosphate (TAT-59)Shibata J1, Toko T, Saito H, Lykkesfeldt AE, Fujioka A, Sato K, Hashimoto A, Wierzba K, Yamada Y.Author information1Hanno Research Center, Taiho Pharmaceutical Co., Ltd., 1-27 Misugidai, Hanno-City, Saitama, 357-8527, Japan.Erratum inCancer Chemother Pharmacol 2000;46(2):172. AbstractPURPOSE: We evaluated miproxifene phosphate (TAT-59) to elucidate its efficacy in antiestrogen therapy for breast cancer patients and to assess its tissue-selective estrogenic/antiestrogenic activity.METHODS: Using DP-TAT-59, a major and active metabolite of TAT-59, an in vitro cell growth inhibition test was performed. Antitumor activity was determined using TAT-59 against human tumor xenografts of the MCF-7 and the Br-10 cell lines andMCF-7-derived tamoxifen-resistant cell lines, R-27 and FST-1. The antitumor activity of DP-TAT-59 and DM-DP-TAT-59, major metabolites of TAT-59 found in human blood following a TAT-59 dose, was also examined after intravenous administration to experimental animals. The residual estrogenic activity of TAT-59, evaluated in terms of bone and lipid metabolism in ovariectomized rats, was then comparedwith that of tamoxifen.RESULTS: DP-TAT-59 significantly inhibited the proliferation of estrogen receptor-positive MCF-7 and T-47D tumor cells in the presence of 1 nM estradiol. TAT-59, given to mice bearing MCF-7 or Br-10 xenografts, at the dose level of 5 mg/kg, exerted a significant growth inhibitory effect that was stronger than that of tamoxifen. Moreover, R-27 and FST-1 tumors, which show a resistance to tamoxifen, responded strongly to TAT-59, suggesting that TAT-59 might be effective against tumors resistant to tamoxifen. The metabolites of TAT-59, DP-TAT-59 and DM-DP-TAT-59, showed similar antitumor activity. Both TAT-59 and tamoxifen suppressed the decrease in bone density and reduced the blood cholesterol levels in ovariectomized rats, suggesting that the estrogenic activity of TAT-59 is comparable to that of tamoxifen.CONCLUSIONS: On the basis of the above results, one may expect TAT-59 to become an effective drug in patients with tumors less sensitive to tamoxifen, while its estrogenic activity as determined by bone and lipid metabolism is similar to that of tamoxifen.PMID: 10663628 [PubMed - indexed for MEDLINE] ShareMeSH Terms, SubstancesMeSH TermsAnimalsAntineoplastic Agents, Hormonal/pharmacologyBreast Neoplasms/pathology*Cell Division/drug effectsDrug Screening Assays, AntitumorEstradiol/pharmacologyEstrogen Antagonists/pharmacology*FemaleHumansLipid MetabolismMiceMice, Inbred BALB CRatsRats, Sprague-DawleyReceptors, Estrogen/physiologyTamoxifen/analogs & derivatives*Tamoxifen/pharmacologyTransplantation, HeterologousTumor Cells, Cultured/drug effectsSubstancesAntineoplastic Agents, HormonalEstrogen AntagonistsReceptors, EstrogenTamoxifenTAT 59EstradiolLinkOut - more resourcesOther Literature SourcesAccess more work from the authors - ResearchGateMedicalBreast Cancer - MedlinePlus Health InformationMiscellaneousESTRADIOL - Hazardous Substances Data BankTAMOXIFEN - Hazardous Substances Data BankPubMed Commons home Cancer Chemother Pharmacol. 2000;45(2):133-41. DMMZO8X RU https://pubmed.ncbi.nlm.nih.gov/10663628 DMXT36M DI DMXT36M DMXT36M DN Mivazerol DMXT36M MI TTQ8AFT DMXT36M MN Adrenergic receptor Alpha-2 (ADRA2) DMXT36M MT DTT DMXT36M MA Agonist DMXT36M RN Alpha-2 and imidazoline receptor agonists. Their pharmacology and therapeutic role. Anaesthesia. 1999 Feb;54(2):146-65. DMXT36M RU https://pubmed.ncbi.nlm.nih.gov/10215710 DMJ59A4 DI DMJ59A4 DMJ59A4 DN MOFEGILINE DMJ59A4 MI TTGP7BY DMJ59A4 MN Monoamine oxidase type B (MAO-B) DMJ59A4 MT DTT DMJ59A4 MA Modulator DMJ59A4 RN Structural and mechanistic studies of mofegiline inhibition of recombinant human monoamine oxidase B. J Med Chem. 2008 Dec 25;51(24):8019-26. DMJ59A4 RU https://pubmed.ncbi.nlm.nih.gov/19053775 DMZAL8C DI DMZAL8C DMZAL8C DN Motesanib DMZAL8C MI TTI2WET DMZAL8C MN Platelet-derived growth factor receptor (PDGFR) DMZAL8C MT DTT DMZAL8C MA Inhibitor DMZAL8C RN Clinical pipeline report, company report or official report of Amgen (2009). DMZAL8C RU http://www.amgen.com/science/pipe.jsp DMZAL8C DI DMZAL8C DMZAL8C DN Motesanib DMZAL8C MI TTX41N9 DMZAL8C MN Tyrosine-protein kinase Kit (KIT) DMZAL8C MT DTT DMZAL8C MA Inhibitor DMZAL8C RN Clinical pipeline report, company report or official report of Amgen (2009). DMZAL8C RU http://www.amgen.com/science/pipe.jsp DMZAL8C DI DMZAL8C DMZAL8C DN Motesanib DMZAL8C MI TTUTJGQ DMZAL8C MN Vascular endothelial growth factor receptor 2 (KDR) DMZAL8C MT DTT DMZAL8C MA Inhibitor DMZAL8C RN Clinical pipeline report, company report or official report of Amgen (2009). DMZAL8C RU http://www.amgen.com/science/pipe.jsp DMYQZBT DI DMYQZBT DMYQZBT DN MR-889 DMYQZBT MI TTPLTSQ DMYQZBT MN Neutrophil elastase (NE) DMYQZBT MT DTT DMYQZBT MA Inhibitor DMYQZBT RN Neutrophil elastase inhibitors as treatment for COPD. Expert Opin Investig Drugs. 2002 Jul;11(7):965-80. DMYQZBT RU https://pubmed.ncbi.nlm.nih.gov/12084007 DMNX0JH DI DMNX0JH DMNX0JH DN N-0861 DMNX0JH MI TTK25J1 DMNX0JH MN Adenosine A1 receptor (ADORA1) DMNX0JH MT DTT DMNX0JH MA Antagonist DMNX0JH RN N-0861 selectively antagonizes adenosine A1 receptors in vivo. Eur J Pharmacol. 1992 May 27;216(1):9-16. DMNX0JH RU https://pubmed.ncbi.nlm.nih.gov/1526257 DMXHWK6 DI DMXHWK6 DMXHWK6 DN Neutralase DMXHWK6 MI TTR7GJO DMXHWK6 MN Heparanase (HPSE) DMXHWK6 MT DTT DMXHWK6 MA Modulator DMXHWK6 RN Heparanase neutralizes the anticoagulation properties of heparin and low-molecular-weight heparin. J Thromb Haemost. 2006 Mar;4(3):560-5. DMXHWK6 RU https://pubmed.ncbi.nlm.nih.gov/16460439 DMJL5TR DI DMJL5TR DMJL5TR DN NOLOMIROLE HYDROCHLORIDE DMJL5TR MI TT2NUT5 DMJL5TR MN Adrenergic receptor alpha-2C (ADRA2C) DMJL5TR MT DTT DMJL5TR MA Modulator DMJL5TR RN Effect of nolomirole on monocrotaline-induced heart failure. Pharmacol Res. 2004 Jan;49(1):1-5. DMJL5TR RU https://pubmed.ncbi.nlm.nih.gov/14597145 DMJL5TR DI DMJL5TR DMJL5TR DN NOLOMIROLE HYDROCHLORIDE DMJL5TR MI TTEX248 DMJL5TR MN Dopamine D2 receptor (D2R) DMJL5TR MT DTT DMJL5TR MA Agonist DMJL5TR RN Effect of nolomirole on monocrotaline-induced heart failure. Pharmacol Res. 2004 Jan;49(1):1-5. DMJL5TR RU https://pubmed.ncbi.nlm.nih.gov/14597145 DMMDY27 DI DMMDY27 DMMDY27 DN Nuleusin DMMDY27 MI TTF89GD DMMDY27 MN Interleukin-2 (IL2) DMMDY27 MT DTT DMMDY27 MA Agonist DMMDY27 RN Expression, purification and characterization of recombinant human interleukin-2-serum albumin (rhIL-2-HSA) fusion protein in Pichia pastoris. Protein Expr Purif. 2012 Jul;84(1):154-60. DMMDY27 RU https://pubmed.ncbi.nlm.nih.gov/22609631 DMQN3JX DI DMQN3JX DMQN3JX DN Ocinaplon DMQN3JX MI TTEX6LM DMQN3JX MN GABA(A) receptor gamma-3 (GABRG3) DMQN3JX MT DTT DMQN3JX MA Modulator DMQN3JX RN Discriminative stimulus properties of GABAA receptor positive allosteric modulators TPA023, ocinaplon and NG2-73 in rats trained to discriminate chlordiazepoxide or zolpidem. Eur J Pharmacol. 2011 Oct 1;668(1-2):190-3. DMQN3JX RU https://pubmed.ncbi.nlm.nih.gov/21762686 DM0O2HP DI DM0O2HP DM0O2HP DN OLAMUFLOXACIN MESILATE DM0O2HP MI TTN6J5F DM0O2HP MN Bacterial DNA gyrase (Bact gyrase) DM0O2HP MT DTT DM0O2HP MA Modulator DM0O2HP RN Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41. DM0O2HP RU https://www.ncbi.nlm.nih.gov/pubmed/15950434 DM1RKWV DI DM1RKWV DM1RKWV DN ONO-3805 DM1RKWV MI TT2A0DR DM1RKWV MN Oxo-5-alpha-steroid 4-dehydrogenase (SRD5A) DM1RKWV MT DTT DM1RKWV MA Modulator DM1RKWV RN Significant role of 5 alpha-reductase on feedback effects of androgen in rat anterior pituitary cells demonstrated with a nonsteroidal 5 alpha-redu... J Androl. 1994 Nov-Dec;15(6):521-7. DM1RKWV RU https://www.ncbi.nlm.nih.gov/pubmed/7721654 DMEDLXJ DI DMEDLXJ DMEDLXJ DN ORBOFIBAN DMEDLXJ MI TT38RM1 DMEDLXJ MN Glycoprotein IIb/IIIa receptor (GPIIb/IIIa) DMEDLXJ MT DTT DMEDLXJ MA Modulator DMEDLXJ RN Orbofiban: an orally active GPIIb/IIIa platelet receptor antagonist. Med Res Rev. 2001 May;21(3):211-26. DMEDLXJ RU https://www.ncbi.nlm.nih.gov/pubmed/11301411 DMVRA8N DI DMVRA8N DMVRA8N DN Org-2766 DMVRA8N MI TTEDJN4 DMVRA8N MN Low-affinity nerve growth factor receptor (NGFR) DMVRA8N MT DTT DMVRA8N MA Modulator DMVRA8N RN Effects of the ACTH4-9 analog Org2766 on brain plasticity: modulation of excitatory neurotransmission. Psychoneuroendocrinology. 1992 Aug;17(4):315-25. DMVRA8N RU https://pubmed.ncbi.nlm.nih.gov/1332099 DMN7TL8 DI DMN7TL8 DMN7TL8 DN Osutidine DMN7TL8 MI TTQHJ1K DMN7TL8 MN Histamine H2 receptor (H2R) DMN7TL8 MT DTT DMN7TL8 MA Antagonist DMN7TL8 RN Effects of osutidine (T-593) and its enantiomers on gastric mucosal hemodynamics and mucosal integrity in anesthetized rats. Arzneimittelforschung. 2001 Jan;51(1):46-50. DMN7TL8 RU https://pubmed.ncbi.nlm.nih.gov/11215325 DMGOPMK DI DMGOPMK DMGOPMK DN Otamixaban DMGOPMK MI TTCIHJA DMGOPMK MN Coagulation factor Xa (F10) DMGOPMK MT DTT DMGOPMK MA Inhibitor DMGOPMK RN Pharma & Vaccines. Product Development Pipeline. April 29 2009. DMGOPMK RU http://en.sanofi-aventis.com/binaries/RD_Phase_III_EN_tcm28-24007.pdf DMWPT8J DI DMWPT8J DMWPT8J DN Oxibendazole DMWPT8J MI TTORYTW DMWPT8J MN Polymerase unspecific (POL) DMWPT8J MT DTT DMWPT8J MA Inhibitor DMWPT8J RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DMWPT8J RU https://pubmed.ncbi.nlm.nih.gov/10592235 DMPEHBJ DI DMPEHBJ DMPEHBJ DN OX-NLA DMPEHBJ MI TT7CXIM DMPEHBJ MN Histamine receptor (HR) DMPEHBJ MT DTT DMPEHBJ MA Antagonist DMPEHBJ RN Clinical pipeline report, company report or official report of Orexo. DMPEHBJ RU http://www.orexo.com/Portfolio/OX-NLA/ DMFNLDY DI DMFNLDY DMFNLDY DN P-1 DMFNLDY MI TTSXVID DMFNLDY MN Nuclear factor NF-kappa-B (NFKB) DMFNLDY MT DTT DMFNLDY MA Modulator DMFNLDY RN Chinese herbal medicine for atopic eczema. Cochrane Database Syst Rev. 2004 Oct 18;(4):CD002291. DMFNLDY RU https://pubmed.ncbi.nlm.nih.gov/15495031 DM1FST8 DI DM1FST8 DM1FST8 DN Pazinaclone DM1FST8 MI TTEX6LM DM1FST8 MN GABA(A) receptor gamma-3 (GABRG3) DM1FST8 MT DTT DM1FST8 MA Modulator DM1FST8 RN The benzodiazepine binding site of GABA(A) receptors as a target for the development of novel anxiolytics. Expert Opin Investig Drugs. 2005 May;14(5):601-18. DM1FST8 RU https://pubmed.ncbi.nlm.nih.gov/15926867 DM4IM0G DI DM4IM0G DM4IM0G DN Pexelizumab DM4IM0G MI TTKANGO DM4IM0G MN Complement C5 (CO5) DM4IM0G MT DTT DM4IM0G RN Pexelizumab reduces death and myocardial infarction in higher risk cardiac surgical patients. Ann Thorac Surg. 2006 Aug;82(2):486-92. DM4IM0G RU https://pubmed.ncbi.nlm.nih.gov/16863750 DMXEU14 DI DMXEU14 DMXEU14 DN PF-1913539 DMXEU14 MI TTM2AOE DMXEU14 MN Adenosine A2a receptor (ADORA2A) DMXEU14 MT DTT DMXEU14 MA Antagonist DMXEU14 RN Blockade of A2A adenosine receptors prevents basic fibroblast growth factor-induced reactive astrogliosis in rat striatal primary astrocytes. Glia. 2003 Aug;43(2):190-4. DMXEU14 RU https://pubmed.ncbi.nlm.nih.gov/12838511 DMXEU14 DI DMXEU14 DMXEU14 DN PF-1913539 DMXEU14 MI TTNE7KG DMXEU14 MN Adenosine A2b receptor (ADORA2B) DMXEU14 MT DTT DMXEU14 MA Antagonist DMXEU14 RN Differences in the order of potency for agonists but not antagonists at human and rat adenosine A2A receptors. Biochem Pharmacol. 1999 Jan 1;57(1):65-75. DMXEU14 RU https://pubmed.ncbi.nlm.nih.gov/9920286 DMXEU14 DI DMXEU14 DMXEU14 DN PF-1913539 DMXEU14 MI TTVBPDM DMXEU14 MN Metabotropic glutamate receptor 1 (mGluR1) DMXEU14 MT DTT DMXEU14 MA Antagonist DMXEU14 RN Pfizer. Product Development Pipeline. March 31 2009. DMXEU14 RU http://media.pfizer.com/files/research/pipeline/2009_0331/pipeline_2009_0331.pdf DMXSTRM DI DMXSTRM DMXSTRM DN Pibutidine DMXSTRM MI TTQHJ1K DMXSTRM MN Histamine H2 receptor (H2R) DMXSTRM MT DTT DMXSTRM MA Modulator DMXSTRM RN Comparative pharmacology of epibatidine: a potent agonist for neuronal nicotinic acetylcholine receptors. Mol Pharmacol. 1995 Oct;48(4):774-82. DMXSTRM RU https://pubmed.ncbi.nlm.nih.gov/7476906 DMQXJDM DI DMQXJDM DMQXJDM DN Piroximone DMQXJDM MI TTUST1O DMQXJDM MN Phosphodiesterase (PDE) DMQXJDM MT DTT DMQXJDM MA Inhibitor DMQXJDM RN Circulatory effects of the PDE-inhibitors piroximone and enoximone. Br J Clin Pharmacol. 1993 Oct;36(4):309-14. DMQXJDM RU https://pubmed.ncbi.nlm.nih.gov/12959308 DMDZBIQ DI DMDZBIQ DMDZBIQ DN PMI-001 DMDZBIQ MI TTF89GD DMDZBIQ MN Interleukin-2 (IL2) DMDZBIQ MT DTT DMDZBIQ MA Inhibitor DMDZBIQ RN Development of a botanical anti-arthritis drug, PMI-001. SBIR.STTR America's Seed Fund. DMDZBIQ RU https://www.sbir.gov/sbirsearch/detail/275638 DMDZBIQ DI DMDZBIQ DMDZBIQ DN PMI-001 DMDZBIQ MI TTVKILB DMDZBIQ MN Prostaglandin G/H synthase 2 (COX-2) DMDZBIQ MT DTT DMDZBIQ MA Inhibitor DMDZBIQ RN Development of a botanical anti-arthritis drug, PMI-001. SBIR.STTR America's Seed Fund. DMDZBIQ RU https://www.sbir.gov/sbirsearch/detail/275638 DM04ZUW DI DM04ZUW DM04ZUW DN Ponalrestat DM04ZUW MI TTFBNVI DM04ZUW MN Aldose reductase (AKR1B1) DM04ZUW MT DTT DM04ZUW MA Inhibitor DM04ZUW RN Ponalrestat, an aldose reductase inhibitor, inhibits cachexia syndrome induced by colon26 adenocarcinoma in mice. Anticancer Res. 1999 Sep-Oct;19(5B):4105-11. DM04ZUW RU https://pubmed.ncbi.nlm.nih.gov/10628361 DM04ZUW DI DM04ZUW DM04ZUW DN Ponalrestat DM04ZUW MI TTN7Y4P DM04ZUW MN Sodium/glucose cotransporter 2 (SLC5A4) DM04ZUW MT DTT DM04ZUW MA Blocker DM04ZUW RN Clinical pipeline report, company report or official report of ISIS Pharmaceuticals (2009). DM04ZUW RU http://www.isispharm.com/Pipeline/index.htm DML6EWH DI DML6EWH DML6EWH DN Posatirelin DML6EWH MI TT4J8MF DML6EWH MN Thyrotropin-releasing hormone receptor (TRHR) DML6EWH MT DTT DML6EWH MA Modulator DML6EWH RN TRH analogs at Gedeon Richter Ltd.: highlights of experimental and clinical efficacy of posatirelin. Acta Pharm Hung. 2002;72(1):62-8. DML6EWH RU https://pubmed.ncbi.nlm.nih.gov/12426788 DMI02PF DI DMI02PF DMI02PF DN PRINOMIDE TROMETHAMINE DMI02PF MI TTVKILB DMI02PF MN Prostaglandin G/H synthase 2 (COX-2) DMI02PF MT DTT DMI02PF MA Inhibitor DMI02PF RN Dexketoprofene, selective cox-1 inhibitor nsaids, without gastrointestinal injury in rats. Acta Gastroenterol Latinoam. 2002 May;32(1):17-20. DMI02PF RU https://pubmed.ncbi.nlm.nih.gov/12136686 DMW9H7M DI DMW9H7M DMW9H7M DN Propiram fumarate DMW9H7M MI TTN4QDT DMW9H7M MN Opioid receptor (OPR) DMW9H7M MT DTT DMW9H7M MA Modulator DMW9H7M RN The relative analgesic efficacy of propiram fumarate, codeine, aspirin, and placebo in post-impaction dental pain. J Clin Pharmacol. 1984 Jan;24(1):35-42. DMW9H7M RU https://pubmed.ncbi.nlm.nih.gov/6368614 DMB069L DI DMB069L DMB069L DN PUMAPRAZOLE DMB069L MI TTLOKXP DMB069L MN Gastric H(+)/K(+) ATPase (Proton pump) DMB069L MT DTT DMB069L MA Modulator DMB069L RN Effects of pumaprazole (BY841), a novel reversible proton pump antagonist, and of omeprazole, on intragastric acidity before and after cure of Heli... Aliment Pharmacol Ther. 1999 Jan;13(1):27-34. DMB069L RU https://www.ncbi.nlm.nih.gov/pubmed/9892876 DMO9XTJ DI DMO9XTJ DMO9XTJ DN Quinelorane DMO9XTJ MI TT4C8EA DMO9XTJ MN Dopamine D3 receptor (D3R) DMO9XTJ MT DTT DMO9XTJ MA Modulator DMO9XTJ RN Quinelorane, a dopamine D3/D2 receptor agonist, reduces prepulse inhibition of startle and ventral pallidal GABA efflux: time course studies.Pharmacol Biochem Behav.2008 Oct;90(4):686-90. DMO9XTJ RU https://www.ncbi.nlm.nih.gov/pubmed/18579193 DMNTURD DI DMNTURD DMNTURD DN Ranagengliotucel-T DMNTURD MI TTI0KH6 DMNTURD MN TGF beta-2 messenger RNA (TGFB2 mRNA) DMNTURD MT DTT DMNTURD RN Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800017210) DMNTURD RU http://adisinsight.springer.com/drugs/800017210 DMAINU1 DI DMAINU1 DMAINU1 DN RB-006 DMAINU1 MI TTFEZ5Q DMAINU1 MN Coagulation factor IX (F9) DMAINU1 MT DTT DMAINU1 MA Inhibitor DMAINU1 RN In-vitro evaluation of anti-factor IXa aptamer on thrombin generation, clotting time, and viscoelastometry. Thromb Haemost. 2009 May;101(5):827-33. DMAINU1 RU https://pubmed.ncbi.nlm.nih.gov/19404534 DMXV28I DI DMXV28I DMXV28I DN RG-12915 DMXV28I MI TTNXLKE DMXV28I MN 5-HT 3 receptor (5HT3R) DMXV28I MT DTT DMXV28I MA Antagonist DMXV28I RN Cataractogenesis in rats induced by in utero exposure to RG 12915, a 5-HT3 antagonist. Fundam Appl Toxicol. 1995 Sep;27(2):270-6. DMXV28I RU https://pubmed.ncbi.nlm.nih.gov/8529823 DMCV0BZ DI DMCV0BZ DMCV0BZ DN RhTPO DMCV0BZ MI TTIHYA4 DMCV0BZ MN Thrombopoietin receptor (MPL) DMCV0BZ MT DTT DMCV0BZ MA Agonist DMCV0BZ RN Emerging drugs for idiopathic thrombocytopenic purpura in adults. Expert Opin Emerg Drugs. 2008 Jun;13(2):237-54. DMCV0BZ RU https://pubmed.ncbi.nlm.nih.gov/18537519 DMBKN4P DI DMBKN4P DMBKN4P DN Riferminogene pecaplasmid DMBKN4P MI TTMY81X DMBKN4P MN Heparin-binding growth factor 1 (FGF1) DMBKN4P MT DTT DMBKN4P MA Modulator DMBKN4P RN Riferminogene pecaplasmide. Am J Cardiovasc Drugs. 2010;10(5):343-6. DMBKN4P RU https://pubmed.ncbi.nlm.nih.gov/20860417 DM0X36Y DI DM0X36Y DM0X36Y DN Ritanserin DM0X36Y MI TTYSN63 DM0X36Y MN 5-HT 2 receptor (5HT2R) DM0X36Y MT DTT DM0X36Y MA Antagonist DM0X36Y RN Characterization of contractile 5-hydroxytryptamine receptor subtypes in the in situ autoperfused kidney in the anaesthetized rat. Eur J Pharmacol. 2008 Sep 11;592(1-3):133-7. DM0X36Y RU https://pubmed.ncbi.nlm.nih.gov/18644367 DM0X36Y DI DM0X36Y DM0X36Y DN Ritanserin DM0X36Y MI TTJQOD7 DM0X36Y MN 5-HT 2A receptor (HTR2A) DM0X36Y MT DTT DM0X36Y MA Antagonist DM0X36Y RN Characterization of contractile 5-hydroxytryptamine receptor subtypes in the in situ autoperfused kidney in the anaesthetized rat. Eur J Pharmacol. 2008 Sep 11;592(1-3):133-7. DM0X36Y RU https://pubmed.ncbi.nlm.nih.gov/18644367 DM0X36Y DI DM0X36Y DM0X36Y DN Ritanserin DM0X36Y MI TT0K1SC DM0X36Y MN 5-HT 2B receptor (HTR2B) DM0X36Y MT DTT DM0X36Y MA Antagonist DM0X36Y RN p-Chloroamphetamine, a serotonin-releasing drug, elicited in rats a hyperglycemia mediated by the 5-HT1A and 5-HT2B/2C receptors. Eur J Pharmacol. 1998 Oct 23;359(2-3):185-90. DM0X36Y RU https://pubmed.ncbi.nlm.nih.gov/9832390 DM0X36Y DI DM0X36Y DM0X36Y DN Ritanserin DM0X36Y MI TTWJBZ5 DM0X36Y MN 5-HT 2C receptor (HTR2C) DM0X36Y MT DTT DM0X36Y MA Antagonist DM0X36Y RN Characterization of contractile 5-hydroxytryptamine receptor subtypes in the in situ autoperfused kidney in the anaesthetized rat. Eur J Pharmacol. 2008 Sep 11;592(1-3):133-7. DM0X36Y RU https://pubmed.ncbi.nlm.nih.gov/18644367 DM0X36Y DI DM0X36Y DM0X36Y DN Ritanserin DM0X36Y MI TT85JO3 DM0X36Y MN 5-HT receptor (5HTR) DM0X36Y MT DTT DM0X36Y MA Antagonist DM0X36Y RN Combined treatment of portal hypertension with ritanserin and propranolol in conscious and unrestrained cirrhotic rats. Hepatology. 1992 May;15(5):878-82. DM0X36Y RU https://pubmed.ncbi.nlm.nih.gov/1568730 DM0X36Y DI DM0X36Y DM0X36Y DN Ritanserin DM0X36Y MI TT4FDG6 DM0X36Y MN Voltage-gated calcium channel alpha Cav2.2 (CACNA1B) DM0X36Y MT DTT DM0X36Y MA Blocker DM0X36Y RN N,N-dialkyl-dipeptidylamines as novel N-type calcium channel blockers. Bioorg Med Chem Lett. 1999 Mar 22;9(6):907-12. DM0X36Y RU https://pubmed.ncbi.nlm.nih.gov/10206559 DM8M1X0 DI DM8M1X0 DM8M1X0 DN Ro-16-6028 DM8M1X0 MI TTPTXIN DM8M1X0 MN Translocator protein (TSPO) DM8M1X0 MT DTT DM8M1X0 MA Modulator DM8M1X0 RN Bretazenil, a benzodiazepine receptor partial agonist, as an adjunct in the prophylactic treatment of OP poisoning. J Appl Toxicol. 2001 Dec;21 Suppl 1:S115-9. DM8M1X0 RU https://www.ncbi.nlm.nih.gov/pubmed/11920931 DMOVJ60 DI DMOVJ60 DMOVJ60 DN RPAF-AH DMOVJ60 MI TTDNFMT DMOVJ60 MN Platelet-activating factor acetylhydrolase (PLA2G7) DMOVJ60 MT DTT DMOVJ60 MA Modulator DMOVJ60 RN Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800006777) DMOVJ60 RU http://adisinsight.springer.com/drugs/800006777 DMPUED3 DI DMPUED3 DMPUED3 DN S-12968 DMPUED3 MI TT5HONZ DMPUED3 MN Calcium channel unspecific (CaC) DMPUED3 MT DTT DMPUED3 MA Blocker DMPUED3 RN (+)-S-12967 and (-)-S-12968: 1,4-dihydropyridine stereoisomers with calcium channel agonistic and antagonistic properties in rat resistance arteries. Br J Pharmacol. 1991 Jul;103(3):1703-8. DMPUED3 RU https://pubmed.ncbi.nlm.nih.gov/1933134 DMSW051 DI DMSW051 DMSW051 DN Sabeluzole DMSW051 MI DECB0K3 DMSW051 MN Cytochrome P450 2D6 (CYP2D6) DMSW051 MT DME DMSW051 MA Metabolism DMSW051 RN Pharmacokinetics of sabeluzole and dextromethorphan oxidation capacity in patients with severe hepatic dysfunction and healthy volunteers. Br J Clin Pharmacol. 2001 Feb;51(2):164-8. DMSW051 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=11259989 DM3KC81 DI DM3KC81 DM3KC81 DN Sanfetrinem DM3KC81 MI TTJP4SM DM3KC81 MN Bacterial Penicillin binding protein (Bact PBP) DM3KC81 MT DTT DM3KC81 MA Modulator DM3KC81 RN Entry of Sanfetrinem into Human Polymorphonuclear Granulocytes and Its Cell-Associated Activity against Intracellular, Penicillin-Resistant Streptococcus pneumoniae DM3KC81 RU https://www.ncbi.nlm.nih.gov/pmc/articles/PMC105677 DMSRJY3 DI DMSRJY3 DMSRJY3 DN Saredutant DMSRJY3 MI TTYO0A3 DMSRJY3 MN Substance-K receptor (TACR2) DMSRJY3 MT DTT DMSRJY3 MA Antagonist DMSRJY3 RN Characterization of species-related differences in the pharmacology of tachykinin NK receptors 1, 2 and 3. Biochem Pharmacol. 2009 May 1;77(9):1522-30. DMSRJY3 RU https://pubmed.ncbi.nlm.nih.gov/19426690 DMCJLD1 DI DMCJLD1 DMCJLD1 DN SCH 727965 DMCJLD1 MI TTH6V3D DMCJLD1 MN Cyclin-dependent kinase 1 (CDK1) DMCJLD1 MT DTT DMCJLD1 MA Inhibitor DMCJLD1 RN Cell cycle kinases as therapeutic targets for cancer. Nat Rev Drug Discov. 2009 Jul;8(7):547-66. DMCJLD1 RU https://pubmed.ncbi.nlm.nih.gov/19568282 DMCJLD1 DI DMCJLD1 DMCJLD1 DN SCH 727965 DMCJLD1 MI TT7HF4W DMCJLD1 MN Cyclin-dependent kinase 2 (CDK2) DMCJLD1 MT DTT DMCJLD1 MA Inhibitor DMCJLD1 RN Cell cycle kinases as therapeutic targets for cancer. Nat Rev Drug Discov. 2009 Jul;8(7):547-66. DMCJLD1 RU https://pubmed.ncbi.nlm.nih.gov/19568282 DMCJLD1 DI DMCJLD1 DMCJLD1 DN SCH 727965 DMCJLD1 MI TT1LVF2 DMCJLD1 MN Cyclin-dependent kinase 9 (CDK9) DMCJLD1 MT DTT DMCJLD1 MA Inhibitor DMCJLD1 RN Cell cycle kinases as therapeutic targets for cancer. Nat Rev Drug Discov. 2009 Jul;8(7):547-66. DMCJLD1 RU https://pubmed.ncbi.nlm.nih.gov/19568282 DMIHQZ8 DI DMIHQZ8 DMIHQZ8 DN Segard DMIHQZ8 MI TTF8CQI DMIHQZ8 MN Tumor necrosis factor (TNF) DMIHQZ8 MT DTT DMIHQZ8 RN Randomized, placebo-controlled trial of the anti-tumor necrosis factor antibody fragment afelimomab in hyperinflammatory response during severe sepsis: The RAMSES Study. Crit Care Med. 2001 Apr;29(4):765-9. DMIHQZ8 RU https://pubmed.ncbi.nlm.nih.gov/11373466 DM3IJMN DI DM3IJMN DM3IJMN DN Seletracetam DM3IJMN MI DE4LYSA DM3IJMN MN Cytochrome P450 3A4 (CYP3A4) DM3IJMN MT DME DM3IJMN MA Metabolism DM3IJMN RN Integrated analysis on the physicochemical properties of dihydropyridine calcium channel blockers in grapefruit juice interactions. Curr Pharm Biotechnol. 2012 Jul;13(9):1705-17. DM3IJMN RU https://www.ncbi.nlm.nih.gov/pubmed/?term=22039822 DM3IJMN DI DM3IJMN DM3IJMN DN Seletracetam DM3IJMN MI TTT3P91 DM3IJMN MN Synaptic vesicle glycoprotein 2A (SV2A) DM3IJMN MT DTT DM3IJMN MA Binder DM3IJMN RN Emerging drugs for epilepsy. Expert Opin Emerg Drugs. 2007 Sep;12(3):407-22. DM3IJMN RU https://pubmed.ncbi.nlm.nih.gov/17874969 DM3FLIX DI DM3FLIX DM3FLIX DN Selfotel DM3FLIX MI TT9IK2Z DM3FLIX MN N-methyl-D-aspartate receptor (NMDAR) DM3FLIX MT DTT DM3FLIX MA Antagonist DM3FLIX RN Neuroprotective agents for the treatment of acute ischemic stroke. Curr Neurol Neurosci Rep. 2003 Jan;3(1):9-20. DM3FLIX RU https://pubmed.ncbi.nlm.nih.gov/12507405 DMRBYH8 DI DMRBYH8 DMRBYH8 DN Sepimostat mesylate DMRBYH8 MI TTEMV5X DMRBYH8 MN Serine protease unspecific (SP) DMRBYH8 MT DTT DMRBYH8 MA Modulator DMRBYH8 RN Effect of FUT-187, oral serine protease inhibitor, on inflammation in the gastric remnant. Gan To Kagaku Ryoho. 1996 Dec;23(14):1971-9. DMRBYH8 RU https://pubmed.ncbi.nlm.nih.gov/8978806 DMPNTDL DI DMPNTDL DMPNTDL DN Seratrodast DMPNTDL MI DEPKLMQ DMPNTDL MN Cytochrome P450 2B6 (CYP2B6) DMPNTDL MT DME DMPNTDL MA Metabolism DMPNTDL RN Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. DMPNTDL RU https://www.ncbi.nlm.nih.gov/pubmed/?term=19515014 DMPNTDL DI DMPNTDL DMPNTDL DN Seratrodast DMPNTDL MI DES5XRU DMPNTDL MN Cytochrome P450 2C8 (CYP2C8) DMPNTDL MT DME DMPNTDL MA Metabolism DMPNTDL RN Identification of cytochromes P450 involved in the human liver microsomal metabolism of the thromboxane A2 inhibitor seratrodast (ABT-001). Drug Metab Dispos. 1997 Jan;25(1):110-5. DMPNTDL RU https://www.ncbi.nlm.nih.gov/pubmed/?term=9010637 DMPNTDL DI DMPNTDL DMPNTDL DN Seratrodast DMPNTDL MI DE5IED8 DMPNTDL MN Cytochrome P450 2C9 (CYP2C9) DMPNTDL MT DME DMPNTDL MA Metabolism DMPNTDL RN Summary of information on human CYP enzymes: human P450 metabolism data. Drug Metab Rev. 2002 Feb-May;34(1-2):83-448. DMPNTDL RU https://www.ncbi.nlm.nih.gov/pubmed/?term=11996015 DMPNTDL DI DMPNTDL DMPNTDL DN Seratrodast DMPNTDL MI DE4LYSA DMPNTDL MN Cytochrome P450 3A4 (CYP3A4) DMPNTDL MT DME DMPNTDL MA Metabolism DMPNTDL RN Identification of cytochromes P450 involved in the human liver microsomal metabolism of the thromboxane A2 inhibitor seratrodast (ABT-001). Drug Metab Dispos. 1997 Jan;25(1):110-5. DMPNTDL RU https://www.ncbi.nlm.nih.gov/pubmed/?term=9010637 DMPNTDL DI DMPNTDL DMPNTDL DN Seratrodast DMPNTDL MI DEGTFWK DMPNTDL MN Mephenytoin 4-hydroxylase (CYP2C19) DMPNTDL MT DME DMPNTDL MA Metabolism DMPNTDL RN Identification of cytochromes P450 involved in the human liver microsomal metabolism of the thromboxane A2 inhibitor seratrodast (ABT-001). Drug Metab Dispos. 1997 Jan;25(1):110-5. DMPNTDL RU https://www.ncbi.nlm.nih.gov/pubmed/?term=9010637 DMPNTDL DI DMPNTDL DMPNTDL DN Seratrodast DMPNTDL MI DE073H6 DMPNTDL MN Prostaglandin G/H synthase 1 (COX-1) DMPNTDL MT DME DMPNTDL MA Metabolism DMPNTDL RN Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. DMPNTDL RU https://www.ncbi.nlm.nih.gov/pubmed/?term=19515014 DMPNTDL DI DMPNTDL DMPNTDL DN Seratrodast DMPNTDL MI TT2O84V DMPNTDL MN Thromboxane A2 receptor (TBXA2R) DMPNTDL MT DTT DMPNTDL MA Antagonist DMPNTDL RN Thromboxane A2 inhibition: therapeutic potential in bronchial asthma. Am J Respir Med. 2002;1(1):11-7. DMPNTDL RU https://pubmed.ncbi.nlm.nih.gov/14720071 DMPNTDL DI DMPNTDL DMPNTDL DN Seratrodast DMPNTDL MI DE85D2P DMPNTDL MN UDP-glucuronosyltransferase 1A9 (UGT1A9) DMPNTDL MT DME DMPNTDL MA Metabolism DMPNTDL RN Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. DMPNTDL RU https://www.ncbi.nlm.nih.gov/pubmed/?term=19515014 DMYQT2V DI DMYQT2V DMYQT2V DN Sibenadet DMYQT2V MI TT2CJVK DMYQT2V MN Adrenergic receptor beta-2 (ADRB2) DMYQT2V MT DTT DMYQT2V MA Modulator DMYQT2V RN The role of the novel D2/beta2-agonist, Viozan (sibenadet HCl), in the treatment of symptoms of chronic obstructive pulmonary disease: results of a... Respir Med. 2003 Jan;97 Suppl A:S23-33. DMYQT2V RU https://www.ncbi.nlm.nih.gov/pubmed/12564608 DMYQT2V DI DMYQT2V DMYQT2V DN Sibenadet DMYQT2V MI TTEX248 DMYQT2V MN Dopamine D2 receptor (D2R) DMYQT2V MT DTT DMYQT2V MA Modulator DMYQT2V RN The role of the novel D2/beta2-agonist, Viozan (sibenadet HCl), in the treatment of symptoms of chronic obstructive pulmonary disease: results of a... Respir Med. 2003 Jan;97 Suppl A:S23-33. DMYQT2V RU https://www.ncbi.nlm.nih.gov/pubmed/12564608 DMZU1TV DI DMZU1TV DMZU1TV DN SIBRAFIBAN DMZU1TV MI TT38RM1 DMZU1TV MN Glycoprotein IIb/IIIa receptor (GPIIb/IIIa) DMZU1TV MT DTT DMZU1TV MA Modulator DMZU1TV RN Pharmacokinetics and pharmacodynamics of sibrafiban, an orally administered GP IIb/IIIa antagonist, following coadministration of aspirin and heparin. J Clin Pharmacol. 2000 May;40(5):488-95. DMZU1TV RU https://www.ncbi.nlm.nih.gov/pubmed/10806602 DM0T2QV DI DM0T2QV DM0T2QV DN Sitimagene ceradenovec DM0T2QV MI TTP3QRF DM0T2QV MN Thymidine kinase 1 (TK1) DM0T2QV MT DTT DM0T2QV MA Modulator DM0T2QV RN Sitimagene ceradenovec: a gene-based drug for the treatment of operable high-grade glioma. Future Oncol. 2010 Nov;6(11):1691-710. DM0T2QV RU https://pubmed.ncbi.nlm.nih.gov/21142657 DMXW1Y3 DI DMXW1Y3 DMXW1Y3 DN SKF-96067 DMXW1Y3 MI TTLOKXP DMXW1Y3 MN Gastric H(+)/K(+) ATPase (Proton pump) DMXW1Y3 MT DTT DMXW1Y3 MA Modulator DMXW1Y3 RN Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41. DMXW1Y3 RU https://www.ncbi.nlm.nih.gov/pubmed/15950434 DMMG47P DI DMMG47P DMMG47P DN SUN-09 DMMG47P MI TTDCVZW DMMG47P MN Gamma-aminobutyric acid B receptor (GABBR) DMMG47P MT DTT DMMG47P MA Modulator DMMG47P RN The effects of the GABA agonist, baclofen, on sleep and breathing. Eur Respir J. 1995 Feb;8(2):230-4. DMMG47P RU https://www.ncbi.nlm.nih.gov/pubmed/7758556 DM6M8ZX DI DM6M8ZX DM6M8ZX DN Sunepitron DM6M8ZX MI TTSQIFT DM6M8ZX MN 5-HT 1A receptor (HTR1A) DM6M8ZX MT DTT DM6M8ZX MA Inhibitor DM6M8ZX RN An integrated in silico 3D model-driven discovery of a novel, potent, and selective amidosulfonamide 5-HT1A agonist (PRX-00023) for the treatment o... J Med Chem. 2006 Jun 1;49(11):3116-35. DM6M8ZX RU https://pubmed.ncbi.nlm.nih.gov/16722631 DM6M8ZX DI DM6M8ZX DM6M8ZX DN Sunepitron DM6M8ZX MI TTNGILX DM6M8ZX MN Adrenergic receptor alpha-1A (ADRA1A) DM6M8ZX MT DTT DM6M8ZX MA Inhibitor DM6M8ZX RN An integrated in silico 3D model-driven discovery of a novel, potent, and selective amidosulfonamide 5-HT1A agonist (PRX-00023) for the treatment o... J Med Chem. 2006 Jun 1;49(11):3116-35. DM6M8ZX RU https://pubmed.ncbi.nlm.nih.gov/16722631 DM6M8ZX DI DM6M8ZX DM6M8ZX DN Sunepitron DM6M8ZX MI TTBRKXS DM6M8ZX MN Adrenergic receptor alpha-1B (ADRA1B) DM6M8ZX MT DTT DM6M8ZX MA Inhibitor DM6M8ZX RN An integrated in silico 3D model-driven discovery of a novel, potent, and selective amidosulfonamide 5-HT1A agonist (PRX-00023) for the treatment o... J Med Chem. 2006 Jun 1;49(11):3116-35. DM6M8ZX RU https://pubmed.ncbi.nlm.nih.gov/16722631 DM6M8ZX DI DM6M8ZX DM6M8ZX DN Sunepitron DM6M8ZX MI TT34BHT DM6M8ZX MN Adrenergic receptor alpha-1D (ADRA1D) DM6M8ZX MT DTT DM6M8ZX MA Inhibitor DM6M8ZX RN An integrated in silico 3D model-driven discovery of a novel, potent, and selective amidosulfonamide 5-HT1A agonist (PRX-00023) for the treatment o... J Med Chem. 2006 Jun 1;49(11):3116-35. DM6M8ZX RU https://pubmed.ncbi.nlm.nih.gov/16722631 DMVB9XC DI DMVB9XC DMVB9XC DN Tanomastat DMVB9XC MI TTLM12X DMVB9XC MN Matrix metalloproteinase-2 (MMP-2) DMVB9XC MT DTT DMVB9XC MA Inhibitor DMVB9XC RN Radiation therapy and biological compounds for consolidation therapy in advanced ovarian cancer. Int J Gynecol Cancer. 2008 Mar-Apr;18 Suppl 1:44-6. DMVB9XC RU https://pubmed.ncbi.nlm.nih.gov/18336400 DMA4WY5 DI DMA4WY5 DMA4WY5 DN Taprostene DMA4WY5 MI TT9B4N3 DMA4WY5 MN Prostaglandin receptor (PTGR) DMA4WY5 MT DTT DMA4WY5 MA Modulator DMA4WY5 RN Partial agonism of taprostene at prostanoid IP receptors in vascular preparations from guinea-pig, rat, and mouse. J Cardiovasc Pharmacol. 2004 Jun;43(6):795-807. DMA4WY5 RU https://pubmed.ncbi.nlm.nih.gov/15167273 DM5G9W0 DI DM5G9W0 DM5G9W0 DN Taranabant DM5G9W0 MI TT6OEDT DM5G9W0 MN Cannabinoid receptor 1 (CB1) DM5G9W0 MT DTT DM5G9W0 MA Antagonist DM5G9W0 RN Central side-effects of therapies based on CB1 cannabinoid receptor agonists and antagonists: focus on anxiety and depression. Best Pract Res Clin Endocrinol Metab. 2009 Feb;23(1):133-44. DM5G9W0 RU https://pubmed.ncbi.nlm.nih.gov/19285266 DM9T6MS DI DM9T6MS DM9T6MS DN Tecadenoson DM9T6MS MI TTK25J1 DM9T6MS MN Adenosine A1 receptor (ADORA1) DM9T6MS MT DTT DM9T6MS MA Agonist DM9T6MS RN CV Therapeutics. Company report from CV Therapeutics, Inc. CV Therapeutics. 2009. DM9T6MS RU http://www.prnewswire.com/cgi-bin/stories.pl?ACCT=104&STORY=/www/story/11-08-2007/0004700893&EDATE= DM9T6MS DI DM9T6MS DM9T6MS DN Tecadenoson DM9T6MS MI DTXD1TQ DM9T6MS MN Equilibrative nucleoside transporter 1 (SLC29A1) DM9T6MS MT DTP DM9T6MS MA Substrate DM9T6MS RN Transport of A1 adenosine receptor agonist tecadenoson by human and mouse nucleoside transporters: evidence for blood-brain barrier transport by murine equilibrative nucleoside transporter 1 mENT1. Drug Metab Dispos. 2013 Apr;41(4):916-22. DM9T6MS RU http://www.ncbi.nlm.nih.gov/pubmed/23388705 DM9T6MS DI DM9T6MS DM9T6MS DN Tecadenoson DM9T6MS MI TTYVX59 DM9T6MS MN Protein kinase C (PRKC) DM9T6MS MT DTT DM9T6MS MA Binder DM9T6MS RN Protein kinase C as a molecular target for cancer prevention by selenocompounds. Nutr Cancer. 2001;40(1):55-63. DM9T6MS RU https://pubmed.ncbi.nlm.nih.gov/11799924 DMYF1DN DI DMYF1DN DMYF1DN DN Terutroban sodium DMYF1DN MI TT2O84V DMYF1DN MN Thromboxane A2 receptor (TBXA2R) DMYF1DN MT DTT DMYF1DN MA Antagonist DMYF1DN RN Terutroban and endothelial TP receptors in atherogenesis. Med Sci (Paris). 2006 Apr;22(4):437-43. DMYF1DN RU https://pubmed.ncbi.nlm.nih.gov/16597416 DMWNXES DI DMWNXES DMWNXES DN Thrombomodulin DMWNXES MI TTAPV67 DMWNXES MN Thrombomodulin (THBD) DMWNXES MT DTT DMWNXES MA Modulator DMWNXES RN Thrombomodulin. Nihon Yakurigaku Zasshi. 2000 Nov;116(5):283-9. DMWNXES RU https://pubmed.ncbi.nlm.nih.gov/11215378 DME5QDP DI DME5QDP DME5QDP DN TIOSPIRONE DME5QDP MI TTSQIFT DME5QDP MN 5-HT 1A receptor (HTR1A) DME5QDP MT DTT DME5QDP MA Inhibitor DME5QDP RN Synthesis and biological activity of the putative metabolites of the atypical antipsychotic agent tiospirone. J Med Chem. 1991 Nov;34(11):3316-28. DME5QDP RU https://pubmed.ncbi.nlm.nih.gov/1683407 DME5QDP DI DME5QDP DME5QDP DN TIOSPIRONE DME5QDP MI TTJQOD7 DME5QDP MN 5-HT 2A receptor (HTR2A) DME5QDP MT DTT DME5QDP MA Inhibitor DME5QDP RN 3-Benzisothiazolylpiperazine derivatives as potential atypical antipsychotic agents. J Med Chem. 1996 Jan 5;39(1):143-8. DME5QDP RU https://pubmed.ncbi.nlm.nih.gov/8568801 DME5QDP DI DME5QDP DME5QDP DN TIOSPIRONE DME5QDP MI TTNGILX DME5QDP MN Adrenergic receptor alpha-1A (ADRA1A) DME5QDP MT DTT DME5QDP MA Inhibitor DME5QDP RN 3-Benzisothiazolylpiperazine derivatives as potential atypical antipsychotic agents. J Med Chem. 1996 Jan 5;39(1):143-8. DME5QDP RU https://pubmed.ncbi.nlm.nih.gov/8568801 DME5QDP DI DME5QDP DME5QDP DN TIOSPIRONE DME5QDP MI TTBRKXS DME5QDP MN Adrenergic receptor alpha-1B (ADRA1B) DME5QDP MT DTT DME5QDP MA Inhibitor DME5QDP RN 3-Benzisothiazolylpiperazine derivatives as potential atypical antipsychotic agents. J Med Chem. 1996 Jan 5;39(1):143-8. DME5QDP RU https://pubmed.ncbi.nlm.nih.gov/8568801 DME5QDP DI DME5QDP DME5QDP DN TIOSPIRONE DME5QDP MI TT34BHT DME5QDP MN Adrenergic receptor alpha-1D (ADRA1D) DME5QDP MT DTT DME5QDP MA Inhibitor DME5QDP RN 3-Benzisothiazolylpiperazine derivatives as potential atypical antipsychotic agents. J Med Chem. 1996 Jan 5;39(1):143-8. DME5QDP RU https://pubmed.ncbi.nlm.nih.gov/8568801 DME5QDP DI DME5QDP DME5QDP DN TIOSPIRONE DME5QDP MI TTEX248 DME5QDP MN Dopamine D2 receptor (D2R) DME5QDP MT DTT DME5QDP MA Inhibitor DME5QDP RN 3-Benzisothiazolylpiperazine derivatives as potential atypical antipsychotic agents. J Med Chem. 1996 Jan 5;39(1):143-8. DME5QDP RU https://pubmed.ncbi.nlm.nih.gov/8568801 DM7RNPJ DI DM7RNPJ DM7RNPJ DN Trenonacog alfa DM7RNPJ MI TTFEZ5Q DM7RNPJ MN Coagulation factor IX (F9) DM7RNPJ MT DTT DM7RNPJ MA Modulator DM7RNPJ RN Pharmacokinetic properties of IB1001, an investigational recombinant factor IX, in patients with haemophilia B: repeat pharmacokinetic evaluation and sialylation analysis.Haemophilia.2012 Nov;18(6):881-7. DM7RNPJ RU https://www.ncbi.nlm.nih.gov/pubmed/22764744 DMOVBSF DI DMOVBSF DMOVBSF DN Tresperimus DMOVBSF MI DE6SOC5 DMOVBSF MN Copper amine oxidase (AOC3) DMOVBSF MT DME DMOVBSF MA Metabolism DMOVBSF RN Metabolism of tresperimus by rat aorta semicarbazide-sensitive amine oxidase (SSAO). Fundam Clin Pharmacol. 2002 Dec;16(6):461-70. DMOVBSF RU https://www.ncbi.nlm.nih.gov/pubmed/?term=12685504 DMXRU9M DI DMXRU9M DMXRU9M DN Valspodar DMXRU9M MI TTCIHJA DMXRU9M MN Coagulation factor Xa (F10) DMXRU9M MT DTT DMXRU9M MA Inhibitor DMXRU9M RN Non-hemostatic activity of coagulation factor Xa: potential implications for various diseases. Curr Opin Pharmacol. 2001 Apr;1(2):169-75. DMXRU9M RU https://pubmed.ncbi.nlm.nih.gov/11714092 DMXRU9M DI DMXRU9M DMXRU9M DN Valspodar DMXRU9M MI TT0JLSD DMXRU9M MN Multidrug resistance protein (MDR) DMXRU9M MT DTT DMXRU9M MA Modulator DMXRU9M RN Intracellular levels of two cyclosporin derivatives valspodar (PSC 833) and cyclosporin a closely associated with multidrug resistance-modulating activity in sublines of human colorectal adenocarcinoma HCT-15. Jpn J Cancer Res. 2001 Oct;92(10):1116-26. DMXRU9M RU https://pubmed.ncbi.nlm.nih.gov/11676863 DMXRU9M DI DMXRU9M DMXRU9M DN Valspodar DMXRU9M MI DTUGYRD DMXRU9M MN P-glycoprotein 1 (ABCB1) DMXRU9M MT DTP DMXRU9M MA Substrate DMXRU9M RN Mammalian drug efflux transporters of the ATP binding cassette (ABC) family in multidrug resistance: A review of the past decade. Cancer Lett. 2016 Jan 1;370(1):153-64. DMXRU9M RU http://www.ncbi.nlm.nih.gov/pubmed/26499806 DMUB0EC DI DMUB0EC DMUB0EC DN VELNACRINE DMUB0EC MI TT1RS9F DMUB0EC MN Acetylcholinesterase (AChE) DMUB0EC MT DTT DMUB0EC MA Inhibitor DMUB0EC RN Synthesis and biological activity of putative mono-hydroxylated metabolites of velnacrine, Bioorg. Med. Chem. Lett. 2(8):865-870 (1992). DMUB0EC RU http://www.sciencedirect.com/science/article/pii/S0960894X00805466 DMFJORV DI DMFJORV DMFJORV DN Verpasep caltespen DMFJORV MI TTVQGI2 DMFJORV MN Mycobacterium Heat shock protein 65 (MycB groL2) DMFJORV MT DTT DMFJORV RN Activity of HspE7, a novel immunotherapy, in patients with anogenital warts. Dis Colon Rectum. 2002 Apr;45(4):502-7. DMFJORV RU https://pubmed.ncbi.nlm.nih.gov/12006932 DMBRYT8 DI DMBRYT8 DMBRYT8 DN XEMILOFIBAN DMBRYT8 MI TT38RM1 DMBRYT8 MN Glycoprotein IIb/IIIa receptor (GPIIb/IIIa) DMBRYT8 MT DTT DMBRYT8 MA Modulator DMBRYT8 RN Glycoprotein IIb/IIIa receptor number and occupancy during chronic administration of an oral antagonist. J Pharmacol Exp Ther. 2000 Nov;295(2):670-6. DMBRYT8 RU https://www.ncbi.nlm.nih.gov/pubmed/11046104 DMBRYT8 DI DMBRYT8 DMBRYT8 DN XEMILOFIBAN DMBRYT8 MI TTJA1ZO DMBRYT8 MN ITGB3 messenger RNA (ITGB3 mRNA) DMBRYT8 MT DTT DMBRYT8 MA Inhibitor DMBRYT8 RN Potent, orally active GPIIb/IIIa antagonists containing a nipecotic acid subunit. Structure-activity studies leading to the discovery of RWJ-53308. J Med Chem. 1999 Dec 16;42(25):5254-65. DMBRYT8 RU https://pubmed.ncbi.nlm.nih.gov/10602710 DM3EZ68 DI DM3EZ68 DM3EZ68 DN Y-23684 DM3EZ68 MI TTEX6LM DM3EZ68 MN GABA(A) receptor gamma-3 (GABRG3) DM3EZ68 MT DTT DM3EZ68 MA Modulator DM3EZ68 RN The pharmacological properties of Y-23684, a benzodiazepine receptor partial agonist. Br J Pharmacol. 1994 Apr;111(4):1170-8. DM3EZ68 RU https://pubmed.ncbi.nlm.nih.gov/7913372 DMFEN6T DI DMFEN6T DMFEN6T DN YM533 DMFEN6T MI TTOFYT1 DMFEN6T MN Prostacyclin receptor (PTGIR) DMFEN6T MT DTT DMFEN6T MA Modulator DMFEN6T RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 345). DMFEN6T RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=345 DM51FVE DI DM51FVE DM51FVE DN Zamifenacin DM51FVE MI TTQ13Z5 DM51FVE MN Muscarinic acetylcholine receptor M3 (CHRM3) DM51FVE MT DTT DM51FVE MA Antagonist DM51FVE RN Drug treatment options for irritable bowel syndrome: managing for success. Drugs Aging. 2001;18(3):201-11. DM51FVE RU https://pubmed.ncbi.nlm.nih.gov/11302287 DMTCP8H DI DMTCP8H DMTCP8H DN Zanapezil DMTCP8H MI TT1RS9F DMTCP8H MN Acetylcholinesterase (AChE) DMTCP8H MT DTT DMTCP8H MA Inhibitor DMTCP8H RN Effect of oral administration of zanapezil (TAK-147) for 21 days on acetylcholine and monoamines levels in the ventral hippocampus of freely moving rats. Br J Pharmacol. 2005 Aug;145(8):1035-44. DMTCP8H RU https://pubmed.ncbi.nlm.nih.gov/15951830 DMIK6C9 DI DMIK6C9 DMIK6C9 DN Zibotentan DMIK6C9 MI TTKRD0G DMIK6C9 MN Endothelin A receptor (EDNRA) DMIK6C9 MT DTT DMIK6C9 MA Antagonist DMIK6C9 RN Clinical pipeline report, company report or official report of AstraZeneca (2009). DMIK6C9 RU http://www.astrazeneca.com/_mshost3690701/content/resources/media/investors/AZN-Q2-2009/AZN-Q2-2009-Pipeline.pdf DM6R3WC DI DM6R3WC DM6R3WC DN BAY 86-6150 DM6R3WC MI TTF0EGX DM6R3WC MN Coagulation factor VII (F7) DM6R3WC MT DTT DM6R3WC MA Modulator DM6R3WC RN Bayer HealthCare and Maxygen Announce Hematology Agreement. U.S. Securities and Exchange Commission. July 2, 2008. DM6R3WC RU http://www.sec.gov/Archives/edgar/data/1068796/000095013408012286/f41954exv99w1.htm DMTR50E DI DMTR50E DMTR50E DN Ilepatril DMTR50E MI TTL69WB DMTR50E MN Angiotensin-converting enzyme (ACE) DMTR50E MT DTT DMTR50E MA Modulator DMTR50E RN Ilepatril (AVE-7688), a vasopeptidase inhibitor for the treatment of hypertension. Curr Opin Investig Drugs. 2008 Mar;9(3):301-9. DMTR50E RU https://pubmed.ncbi.nlm.nih.gov/18311667 DMTR50E DI DMTR50E DMTR50E DN Ilepatril DMTR50E MI TT5TKPM DMTR50E MN Neutral endopeptidase (MME) DMTR50E MT DTT DMTR50E MA Modulator DMTR50E RN Ilepatril (AVE-7688), a vasopeptidase inhibitor for the treatment of hypertension. Curr Opin Investig Drugs. 2008 Mar;9(3):301-9. DMTR50E RU https://pubmed.ncbi.nlm.nih.gov/18311667 DMMT4PB DI DMMT4PB DMMT4PB DN Osanetant DMMT4PB MI TTBPGLU DMMT4PB MN Neuromedin-K receptor (TACR3) DMMT4PB MT DTT DMMT4PB MA Antagonist DMMT4PB RN Pharmacological characterization of senktide-induced tail whips. Neuropharmacology. 2010 Jan;58(1):259-67. DMMT4PB RU https://pubmed.ncbi.nlm.nih.gov/19540857 DMLQVTJ DI DMLQVTJ DMLQVTJ DN Octopamine DMLQVTJ MI TTCIHJA DMLQVTJ MN Coagulation factor Xa (F10) DMLQVTJ MT DTT DMLQVTJ MA Inhibitor DMLQVTJ RN Description of the chemical and pharmacological characteristics of a new hemisynthetic ultra-low-molecular-weight heparin, AVE5026. J Thromb Haemost. 2009 Jul;7(7):1143-51. DMLQVTJ RU https://pubmed.ncbi.nlm.nih.gov/19422447 DMLQVTJ DI DMLQVTJ DMLQVTJ DN Octopamine DMLQVTJ MI DECB0K3 DMLQVTJ MN Cytochrome P450 2D6 (CYP2D6) DMLQVTJ MT DME DMLQVTJ MA Metabolism DMLQVTJ RN Dopamine formation from tyramine by CYP2D6. Biochem Biophys Res Commun. 1998 Aug 28;249(3):838-43. DMLQVTJ RU https://www.ncbi.nlm.nih.gov/pubmed/?term=9731223 DMLQVTJ DI DMLQVTJ DMLQVTJ DN Octopamine DMLQVTJ MI DE4LYSA DMLQVTJ MN Cytochrome P450 3A4 (CYP3A4) DMLQVTJ MT DME DMLQVTJ MA Metabolism DMLQVTJ RN Seville (sour) orange juice: synephrine content and cardiovascular effects in normotensive adults. J Clin Pharmacol. 2001 Oct;41(10):1059-63. DMLQVTJ RU https://www.ncbi.nlm.nih.gov/pubmed/?term=11583473 DMLQVTJ DI DMLQVTJ DMLQVTJ DN Octopamine DMLQVTJ MI DEIBDNY DMLQVTJ MN Cytochrome P450 3A5 (CYP3A5) DMLQVTJ MT DME DMLQVTJ MA Metabolism DMLQVTJ RN Pharmacogenomics as molecular autopsy for forensic toxicology: genotyping cytochrome P450 3A4*1B and 3A5*3 for 25 fentanyl cases. J Anal Toxicol. 2005 Oct;29(7):590-8. DMLQVTJ RU https://www.ncbi.nlm.nih.gov/pubmed/?term=16419387 DMLQVTJ DI DMLQVTJ DMLQVTJ DN Octopamine DMLQVTJ MI DEZV4AP DMLQVTJ MN RNA cytidine acetyltransferase (hALP) DMLQVTJ MT DME DMLQVTJ MA Metabolism DMLQVTJ RN [N-acetylation of biogenic amines in Drosophila virilis]. Genetika. 1997 Jun;33(6):788-92. DMLQVTJ RU https://www.ncbi.nlm.nih.gov/pubmed/?term=9289416 DMQV4C3 DI DMQV4C3 DMQV4C3 DN 4030W92 DMQV4C3 MI TTRK8B9 DMQV4C3 MN Sodium channel unspecific (NaC) DMQV4C3 MT DTT DMQV4C3 MA Modulator DMQV4C3 RN Lack of effect of two oral sodium channel antagonists, lamotrigine and 4030W92, on intradermal capsaicin-induced hyperalgesia model. Pharmacol Biochem Behav. 2004 Jun;78(2):349-55. DMQV4C3 RU https://pubmed.ncbi.nlm.nih.gov/15219777 DMUXMGN DI DMUXMGN DMUXMGN DN 4991W93 DMUXMGN MI TTRK8B9 DMUXMGN MN Sodium channel unspecific (NaC) DMUXMGN MT DTT DMUXMGN MA Modulator DMUXMGN RN CGRP and its receptors provide new insights into migraine pathophysiology. Nat Rev Neurol. 2010 Oct;6(10):573-82. DMUXMGN RU https://pubmed.ncbi.nlm.nih.gov/20820195 DMYOG98 DI DMYOG98 DMYOG98 DN 534U87 DMYOG98 MI TTRK8B9 DMYOG98 MN Sodium channel unspecific (NaC) DMYOG98 MT DTT DMYOG98 MA Modulator DMYOG98 RN The anticonvulsant BW534U87 depresses epileptiform activity in rat hippocampal slices by an adenosine-dependent mechanism and through inhibition of voltage-gated Na+ channels. Br J Pharmacol. 1999 Nov;128(5):1011-20. DMYOG98 RU https://pubmed.ncbi.nlm.nih.gov/10556938 DMG0I6L DI DMG0I6L DMG0I6L DN 97-139 DMG0I6L MI TTKRD0G DMG0I6L MN Endothelin A receptor (EDNRA) DMG0I6L MT DTT DMG0I6L MA Antagonist DMG0I6L RN S-0139 (Shionogi). Curr Opin Investig Drugs. 2002 Jul;3(7):1051-6. DMG0I6L RU https://pubmed.ncbi.nlm.nih.gov/12186266 DMSGY5M DI DMSGY5M DMSGY5M DN 99mTc-ciprofloxacin DMSGY5M MI TTN6J5F DMSGY5M MN Bacterial DNA gyrase (Bact gyrase) DMSGY5M MT DTT DMSGY5M MA Inhibitor DMSGY5M RN Binding of ciprofloxacin labelled with technetium Tc 99m versus 99mTc-pertechnetate to a live and killed equine isolate of Escherichia coli. Can J Vet Res. 2005 October; 69(4): 272-277. DMSGY5M RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1250239/ DMEG240 DI DMEG240 DMEG240 DN A-437203 DMEG240 MI TT4C8EA DMEG240 MN Dopamine D3 receptor (D3R) DMEG240 MT DTT DMEG240 MA Modulator DMEG240 RN Association of dopamine-related genetic loci to dopamine D3 receptor antagonist ABT-925 clinical response.Transl Psychiatry.2013 Apr 9;3:e245. DMEG240 RU https://www.ncbi.nlm.nih.gov/pubmed/23571810 DMX56G4 DI DMX56G4 DMX56G4 DN A-5021 DMX56G4 MI TTF1HYB DMX56G4 MN Herpesvirus DNA polymerase (KSHV DNAP) DMX56G4 MT DTT DMX56G4 MA Modulator DMX56G4 RN Mode of action of (1'S,2'R)-9-[[1',2'-bis(hydroxymethyl) cycloprop-1'-yl]methyl]guanine (A-5021) against herpes simplex virus type 1 and type 2 and varicella-zoster virus. Antimicrob Agents Chemother. 1998 Aug;42(8):2095-102. DMX56G4 RU https://pubmed.ncbi.nlm.nih.gov/9687413 DMF4MRD DI DMF4MRD DMF4MRD DN A-75925 DMF4MRD MI TT5FNQT DMF4MRD MN Human immunodeficiency virus Protease (HIV PR) DMF4MRD MT DTT DMF4MRD MA Inhibitor DMF4MRD RN Solvation studies of DMP323 and A76928 bound to HIV protease: analysis of water sites using grand canonical Monte Carlo simulations. Protein Sci. 1998 Mar;7(3):573-9. DMF4MRD RU https://pubmed.ncbi.nlm.nih.gov/9541388 DM7VSBH DI DM7VSBH DM7VSBH DN A-86719.1 DM7VSBH MI TTN6J5F DM7VSBH MN Bacterial DNA gyrase (Bact gyrase) DM7VSBH MT DTT DM7VSBH MA Modulator DM7VSBH RN Efficacy of ABT-719, a 2-pyridone antimicrobial, against enterococci, Escherichia coli, and Pseudomonas aeruginosa in experimental murine pyeloneph... J Antimicrob Chemother. 1996 Oct;38(4):641-53. DM7VSBH RU https://www.ncbi.nlm.nih.gov/pubmed/8937959 DMB5TH3 DI DMB5TH3 DMB5TH3 DN AA-193 DMB5TH3 MI TTIF3GB DMB5TH3 MN Glucose transporter type 9 (GLUT9) DMB5TH3 MT DTT DMB5TH3 MA Modulator DMB5TH3 RN Uricosurics inhibit urate transporter in rat renal brush border membrane vesicles. Eur J Pharmacol. 1990 Oct 23;187(3):303-12. DMB5TH3 RU https://pubmed.ncbi.nlm.nih.gov/2073918 DM78623 DI DM78623 DM78623 DN AA-2379 DM78623 MI TTUST1O DM78623 MN Phosphodiesterase (PDE) DM78623 MT DTT DM78623 MA Inhibitor DM78623 RN Inhibitory effects of methyl 7-butyl-4,5,6,7-tetrahydro-3-methylamino-4,6-dioxo-5-propyl- 2H-pyrazolo[3,4-d]pyrimidine-2-carboxylate (AA-2379) on lysosomal enzyme and arachidonic acid release from rat polymorphonuclear leukocytes and its mode of action. Agents Actions. 1989 Nov;28(3-4):248-55. DM78623 RU https://pubmed.ncbi.nlm.nih.gov/2556899 DM8DT7U DI DM8DT7U DM8DT7U DN ABT-089 DM8DT7U MI TTL1ATN DM8DT7U MN Neuronal acetylcholine receptor alpha-4/beta-2 (CHRNA4/B2) DM8DT7U MT DTT DM8DT7U MA Modulator DM8DT7U RN Selectivity of ABT-089 for alpha4beta2* and alpha6beta2* nicotinic acetylcholine receptors in brain.Biochem Pharmacol.2009 Oct 1;78(7):795-802. DM8DT7U RU https://www.ncbi.nlm.nih.gov/pubmed/19481067 DMNP72I DI DMNP72I DMNP72I DN ABT-418 DMNP72I MI TT4H1MQ DMNP72I MN Neuronal acetylcholine receptor alpha-4 (CHRNA4) DMNP72I MT DTT DMNP72I MA Agonist DMNP72I RN (S)-3-methyl-5-(1-methyl-2-pyrrolidinyl)isoxazole (ABT 418): a novel cholinergic ligand with cognition-enhancing and anxiolytic activities: II. In vivo characterization. J Pharmacol Exp Ther. 1994 Jul;270(1):319-28. DMNP72I RU https://pubmed.ncbi.nlm.nih.gov/7913497 DMNP72I DI DMNP72I DMNP72I DN ABT-418 DMNP72I MI TT5KPZR DMNP72I MN Neuronal acetylcholine receptor beta-2 (CHRNB2) DMNP72I MT DTT DMNP72I MA Agonist DMNP72I RN Nicotine, brain nicotinic receptors, and neuropsychiatric disorders. Arch Med Res. 2000 Mar-Apr;31(2):131-44. DMNP72I RU https://pubmed.ncbi.nlm.nih.gov/10880717 DMNP72I DI DMNP72I DMNP72I DN ABT-418 DMNP72I MI TTJSZTB DMNP72I MN Nicotinic acetylcholine receptor (nAChR) DMNP72I MT DTT DMNP72I MA Agonist DMNP72I RN Enhancement of sustained attention performance by the nicotinic acetylcholine receptor agonist ABT-418 in intact but not basal forebrain-lesioned rats. Psychopharmacology (Berl). 1999 May;144(2):175-82. DMNP72I RU https://pubmed.ncbi.nlm.nih.gov/10394999 DMGMBCW DI DMGMBCW DMGMBCW DN ABT-594 DMGMBCW MI TT4H1MQ DMGMBCW MN Neuronal acetylcholine receptor alpha-4 (CHRNA4) DMGMBCW MT DTT DMGMBCW MA Agonist DMGMBCW RN The nicotinic acetylcholine receptor agonist ABT-594 increases FGF-2 expression in various rat brain regions. Neuroreport. 1999 Dec 16;10(18):3909-13. DMGMBCW RU https://pubmed.ncbi.nlm.nih.gov/10716232 DMGMBCW DI DMGMBCW DMGMBCW DN ABT-594 DMGMBCW MI TT5KPZR DMGMBCW MN Neuronal acetylcholine receptor beta-2 (CHRNB2) DMGMBCW MT DTT DMGMBCW MA Agonist DMGMBCW RN The nicotinic acetylcholine receptor agonist ABT-594 increases FGF-2 expression in various rat brain regions. Neuroreport. 1999 Dec 16;10(18):3909-13. DMGMBCW RU https://pubmed.ncbi.nlm.nih.gov/10716232 DMGMBCW DI DMGMBCW DMGMBCW DN ABT-594 DMGMBCW MI TTJSZTB DMGMBCW MN Nicotinic acetylcholine receptor (nAChR) DMGMBCW MT DTT DMGMBCW MA Agonist DMGMBCW RN ABT-594 [(R)-5-(2-azetidinylmethoxy)-2-chloropyridine]: a novel, orally effective antinociceptive agent acting via neuronal nicotinic acetylcholine receptors: II. In vivo characterization. J Pharmacol Exp Ther. 1998 May;285(2):787-94. DMGMBCW RU https://pubmed.ncbi.nlm.nih.gov/9580627 DMDQVY4 DI DMDQVY4 DMDQVY4 DN ABT-724 DMDQVY4 MI TTE0A2F DMDQVY4 MN Dopamine D4 receptor (D4R) DMDQVY4 MT DTT DMDQVY4 MA Agonist DMDQVY4 RN Activation of dopamine D4 receptors by ABT-724 induces penile erection in rats. Proc Natl Acad Sci U S A. 2004 April 27; 101(17): 6758-6763. DMDQVY4 RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC404118/ DMM02XV DI DMM02XV DMM02XV DN AD-5467 DMM02XV MI TTFBNVI DMM02XV MN Aldose reductase (AKR1B1) DMM02XV MT DTT DMM02XV MA Inhibitor DMM02XV RN Studies on antidiabetic agents. IX. A new aldose reductase inhibitor, AD-5467, and related 1,4-benzoxazine and 1,4-benzothiazine derivatives: synthesis and biological activity. Chem Pharm Bull (Tokyo). 1990 May;38(5):1238-45. DMM02XV RU https://pubmed.ncbi.nlm.nih.gov/2118427 DMTOCV7 DI DMTOCV7 DMTOCV7 DN Adaprolol maleate-SME DMTOCV7 MI TTMXGCW DMTOCV7 MN Adrenergic receptor beta-3 (ADRB3) DMTOCV7 MT DTT DMTOCV7 MA Modulator DMTOCV7 RN Synthesis and pharmacological activity of adaprolol enantiomers: a new soft drug for treating glaucoma. J Ocul Pharmacol Ther. 1996 Summer;12(2):115-22. DMTOCV7 RU https://pubmed.ncbi.nlm.nih.gov/8773927 DMMKFUP DI DMMKFUP DMMKFUP DN Adatanserin DMMKFUP MI TTSQIFT DMMKFUP MN 5-HT 1A receptor (HTR1A) DMMKFUP MT DTT DMMKFUP MA Agonist DMMKFUP RN Novel drugs and therapeutic targets for severe mood disorders. Neuropsychopharmacology. 2008 Aug;33(9):2080-92. DMMKFUP RU https://pubmed.ncbi.nlm.nih.gov/18172433 DMMKFUP DI DMMKFUP DMMKFUP DN Adatanserin DMMKFUP MI TTJQOD7 DMMKFUP MN 5-HT 2A receptor (HTR2A) DMMKFUP MT DTT DMMKFUP MA Antagonist DMMKFUP RN Novel drugs and therapeutic targets for severe mood disorders. Neuropsychopharmacology. 2008 Aug;33(9):2080-92. DMMKFUP RU https://pubmed.ncbi.nlm.nih.gov/18172433 DMPFQLX DI DMPFQLX DMPFQLX DN ADL 10-0101 DMPFQLX MI TTQW87Y DMPFQLX MN Opioid receptor kappa (OPRK1) DMPFQLX MT DTT DMPFQLX MA Agonist DMPFQLX RN Analgesia from a peripherally active kappa-opioid receptor agonist in patients with chronic pancreatitis. Pain. 2003 Jan;101(1-2):89-95. DMPFQLX RU https://pubmed.ncbi.nlm.nih.gov/12507703 DMQM54P DI DMQM54P DMQM54P DN ADL-5945 DMQM54P MI TTKWM86 DMQM54P MN Opioid receptor mu (MOP) DMQM54P MT DTT DMQM54P MA Antagonist DMQM54P RN Novel opioid antagonists for opioid-induced bowel dysfunction. Expert Opin Investig Drugs. 2011 Aug;20(8):1047-56. DMQM54P RU https://pubmed.ncbi.nlm.nih.gov/21663526 DMJ8ZFR DI DMJ8ZFR DMJ8ZFR DN ADOZELESIN DMJ8ZFR MI TTUTN1I DMJ8ZFR MN Human Deoxyribonucleic acid (hDNA) DMJ8ZFR MT DTT DMJ8ZFR MA Binder DMJ8ZFR RN Mapping of DNA alkylation sites induced by adozelesin and bizelesin in human cells by ligation-mediated polymerase chain reaction. Biochemistry. 1994 May 17;33(19):6024-30. DMJ8ZFR RU https://pubmed.ncbi.nlm.nih.gov/8180230 DMS8JIU DI DMS8JIU DMS8JIU DN ADROGOLIDE HYDROCHLORIDE DMS8JIU MI TTZFYLI DMS8JIU MN Dopamine D1 receptor (D1R) DMS8JIU MT DTT DMS8JIU MA Agonist DMS8JIU RN Adrogolide HCl (ABT-431; DAS-431), a prodrug of the dopamine D1 receptor agonist, A-86929: preclinical pharmacology and clinical data. CNS Drug Rev. 2001 Fall;7(3):305-16. DMS8JIU RU https://pubmed.ncbi.nlm.nih.gov/11607045 DMZS2M4 DI DMZS2M4 DMZS2M4 DN ADX-10061 DMZS2M4 MI TTZFYLI DMZS2M4 MN Dopamine D1 receptor (D1R) DMZS2M4 MT DTT DMZS2M4 MA Antagonist DMZS2M4 RN Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800001476) DMZS2M4 RU http://adisinsight.springer.com/drugs/800001476 DMZ7WKN DI DMZ7WKN DMZ7WKN DN Adyvia DMZ7WKN MI TTHBTOP DMZ7WKN MN PI3-kinase gamma (PIK3CG) DMZ7WKN MT DTT DMZ7WKN MA Modulator DMZ7WKN RN Insulinotropic agent ID-1101 (4-hydroxyisoleucine) activates insulin signaling in rat.Am J Physiol Endocrinol Metab.2004 Sep;287(3):E463-71. DMZ7WKN RU https://www.ncbi.nlm.nih.gov/pubmed/15082420 DMRWSKX DI DMRWSKX DMRWSKX DN Afegostat DMRWSKX MI TT1B5PU DMRWSKX MN Glucosylceramidase (GBA) DMRWSKX MT DTT DMRWSKX MA Inhibitor DMRWSKX RN Lysosomes as a therapeutic target. Nat Rev Drug Discov. 2019 Dec;18(12):923-948. DMRWSKX RU https://pubmed.ncbi.nlm.nih.gov/31477883 DMSF5VK DI DMSF5VK DMSF5VK DN Affitope AD-02 DMSF5VK MI TTE4KHA DMSF5VK MN Amyloid beta A4 protein (APP) DMSF5VK MT DTT DMSF5VK RN Amyloid-based immunotherapy for Alzheimer's disease in the time of prevention trials: the way forward. Expert Rev Clin Immunol. 2014 Mar;10(3):405-19. DMSF5VK RU https://pubmed.ncbi.nlm.nih.gov/24490853 DM497SK DI DM497SK DM497SK DN Agatolimod DM497SK MI TTSHG0T DM497SK MN Toll-like receptor 9 (TLR9) DM497SK MT DTT DM497SK MA Agonist DM497SK RN Pfizer. Product Development Pipeline. March 31 2009. DM497SK RU http://media.pfizer.com/files/research/pipeline/2009_0331/pipeline_2009_0331.pdf DMZRW5E DI DMZRW5E DMZRW5E DN AGN211745 DMZRW5E MI TTPFN62 DMZRW5E MN VEGFR2 messenger RNA (VEGFR2 mRNA) DMZRW5E MT DTT DMZRW5E RN Teaming up to tackle RNAi delivery challenge. Nat Rev Drug Discov. 2009 Jul;8(7):525-6. DMZRW5E RU https://pubmed.ncbi.nlm.nih.gov/19568274 DME6OXB DI DME6OXB DME6OXB DN AKL-0707 DME6OXB MI TTG4R8V DME6OXB MN Growth hormone-releasing hormone receptor (GHRHR) DME6OXB MT DTT DME6OXB MA Agonist DME6OXB RN A super-agonist of growth hormone-releasing hormone causes rapid improvement of nutritional status in patients with chronic kidney disease. Kidney Int. 2010 Mar;77(5):450-8. 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Pharmacological evaluation of alprenoxime--a new potential antiglaucoma agent. Pharm Res. 1991 Nov;8(11):1389-95. DMIKLRN RU https://pubmed.ncbi.nlm.nih.gov/1798675 DMIAXCZ DI DMIAXCZ DMIAXCZ DN Alrestatin DMIAXCZ MI TTFBNVI DMIAXCZ MN Aldose reductase (AKR1B1) DMIAXCZ MT DTT DMIAXCZ MA Inhibitor DMIAXCZ RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMIAXCZ RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMEKHX0 DI DMEKHX0 DMEKHX0 DN ALS 2-0426 DMEKHX0 MI TTDIGC1 DMEKHX0 MN Dipeptidyl peptidase 4 (DPP-4) DMEKHX0 MT DTT DMEKHX0 MA Inhibitor DMEKHX0 RN Novel Pharmacological Approaches to the Treatment of Type 2 Diabetes. Pharmacological Reviews April 2012 vol. 64 no. 2 188-237. DMEKHX0 RU http://pharmrev.aspetjournals.org/content/64/2/188.full DMAQNBW DI DMAQNBW DMAQNBW DN AM103 DMAQNBW MI TTDMBF5 DMAQNBW MN Arachidonate 5-lipoxygenase activating protein (FLAP) DMAQNBW MT DTT DMAQNBW MA Inhibitor DMAQNBW RN AM103 Experimental Treatment for Respiratory Diseases. Amira Pharmaceuticals/GSK. 2009. DMAQNBW RU http://www.drugdevelopment-technology.com/projects/am103/ DMF8KH7 DI DMF8KH7 DMF8KH7 DN AM336 DMF8KH7 MI TT5HONZ DMF8KH7 MN Calcium channel unspecific (CaC) DMF8KH7 MT DTT DMF8KH7 MA Modulator DMF8KH7 RN Intravenous injection of leconotide, an omega conotoxin: synergistic antihyperalgesic effects with morphine in a rat model of bone cancer pain.Pain Med.2011 Jun;12(6):923-41. DMF8KH7 RU https://www.ncbi.nlm.nih.gov/pubmed/21539704 DMA57O4 DI DMA57O4 DMA57O4 DN Ambasilide DMA57O4 MI TT1VOHK DMA57O4 MN Potassium channel unspecific (KC) DMA57O4 MT DTT DMA57O4 MA Blocker DMA57O4 RN Ambasilide prolongs the action potential and blocks multiple potassium currents in human atrium. J Cardiovasc Pharmacol. 1999 May;33(5):762-71. DMA57O4 RU https://pubmed.ncbi.nlm.nih.gov/10226864 DMRY9V8 DI DMRY9V8 DMRY9V8 DN AMESERGIDE DMRY9V8 MI TTJQOD7 DMRY9V8 MN 5-HT 2A receptor (HTR2A) DMRY9V8 MT DTT DMRY9V8 MA Antagonist DMRY9V8 RN Effects of the serotonin antagonist amesergide on reproduction in female rats. Reprod Toxicol. 1993 Nov-Dec;7(6):607-12. DMRY9V8 RU https://pubmed.ncbi.nlm.nih.gov/8118111 DMMUS8X DI DMMUS8X DMMUS8X DN AMG 108 DMMUS8X MI TT51DEV DMMUS8X MN Interleukin 1 receptor type 2 (IL1R2) DMMUS8X MT DTT DMMUS8X MA Antagonist DMMUS8X RN Clinical pipeline report, company report or official report of Amgen (2009). DMMUS8X RU http://www.amgen.com/science/pipe.jsp DM4RFT8 DI DM4RFT8 DM4RFT8 DN Amifloxacin DM4RFT8 MI TT0IHXV DM4RFT8 MN DNA topoisomerase II (TOP2) DM4RFT8 MT DTT DM4RFT8 MA Inhibitor DM4RFT8 RN Activity of fluoroquinolone antibiotics against Plasmodium falciparum in vitro. Antimicrob Agents Chemother. 1988 Aug;32(8):1182-6. DM4RFT8 RU https://pubmed.ncbi.nlm.nih.gov/2847647 DMGL0Q2 DI DMGL0Q2 DMGL0Q2 DN AN-9 DMGL0Q2 MI TT6R7JZ DMGL0Q2 MN Histone deacetylase 1 (HDAC1) DMGL0Q2 MT DTT DMGL0Q2 MA Inhibitor DMGL0Q2 RN Anticancer activities of histone deacetylase inhibitors. Nat Rev Drug Discov. 2006 Sep;5(9):769-84. DMGL0Q2 RU https://pubmed.ncbi.nlm.nih.gov/16955068 DMBQLS5 DI DMBQLS5 DMBQLS5 DN Angiozyme DMBQLS5 MI TT2Q6G1 DMBQLS5 MN Vascular endothelial growth factor receptor 1 (FLT-1) DMBQLS5 MT DTT DMBQLS5 MA Modulator DMBQLS5 RN An open-label, phase 2 trial of RPI.4610 (Angiozyme) in the treatment of metastatic breast cancer.Cancer.2012 Sep 1;118(17):4098-104. DMBQLS5 RU https://www.ncbi.nlm.nih.gov/pubmed/22281842 DMEO6PR DI DMEO6PR DMEO6PR DN Antide DMEO6PR MI TT8R70G DMEO6PR MN Gonadotropin-releasing hormone receptor (GNRHR) DMEO6PR MT DTT DMEO6PR MA Antagonist DMEO6PR RN Antide (Nal-Lys GnRH antagonist) suppression of pituitary-testicular function and sexual behavior in group-living rhesus monkeys. Physiol Behav. 1991 Aug;50(2):429-35. DMEO6PR RU https://pubmed.ncbi.nlm.nih.gov/1745690 DMGDPSI DI DMGDPSI DMGDPSI DN AOD-9604 DMGDPSI MI TTKMAZ6 DMGDPSI MN Growth hormone receptor (GHR) DMGDPSI MT DTT DMGDPSI MA Agonist DMGDPSI RN Emerging drugs for obesity: linking novel biological mechanisms to pharmaceutical pipelines. Expert Opin Emerg Drugs. 2005 Aug;10(3):643-60. DMGDPSI RU https://pubmed.ncbi.nlm.nih.gov/16083333 DMWDCG7 DI DMWDCG7 DMWDCG7 DN AP-521 DMWDCG7 MI TTSQIFT DMWDCG7 MN 5-HT 1A receptor (HTR1A) DMWDCG7 MT DTT DMWDCG7 MA Agonist DMWDCG7 RN The effects of AP521, a novel anxiolytic drug, in three anxiety models and on serotonergic neural transmission in rats. J Pharmacol Sci. 2015 Jan;127(1):109-16. DMWDCG7 RU https://pubmed.ncbi.nlm.nih.gov/25704026 DMWKJCB DI DMWKJCB DMWKJCB DN AP-5346 DMWKJCB MI TTUTN1I DMWKJCB MN Human Deoxyribonucleic acid (hDNA) DMWKJCB MT DTT DMWKJCB MA Inhibitor DMWKJCB RN Preclinical efficacy and pharmacokinetics of AP5346, a novel diaminocyclohexane-platinum tumor-targeting drug delivery system. Clin Cancer Res. 2006 Apr 1;12(7 Pt 1):2248-54. DMWKJCB RU https://pubmed.ncbi.nlm.nih.gov/16609041 DM8IB6K DI DM8IB6K DM8IB6K DN APC-2059 DM8IB6K MI TTM1TDX DM8IB6K MN Tryptase alpha/beta-1 (Tryptase) DM8IB6K MT DTT DM8IB6K MA Inhibitor DM8IB6K RN Treatment of mildly to moderately active ulcerative colitis with a tryptase inhibitor (APC 2059): an open-label pilot study. Aliment Pharmacol Ther. 2002 Mar;16(3):407-13. DM8IB6K RU https://pubmed.ncbi.nlm.nih.gov/11876693 DM02DNQ DI DM02DNQ DM02DNQ DN APC-366 DM02DNQ MI TTM1TDX DM02DNQ MN Tryptase alpha/beta-1 (Tryptase) DM02DNQ MT DTT DM02DNQ MA Inhibitor DM02DNQ RN Inhibitors of tryptase for the treatment of mast cell-mediated diseases. Curr Pharm Des. 1998 Oct;4(5):381-96. DM02DNQ RU https://pubmed.ncbi.nlm.nih.gov/10197050 DMR3Q82 DI DMR3Q82 DMR3Q82 DN Apricoxib DMR3Q82 MI TTVKILB DMR3Q82 MN Prostaglandin G/H synthase 2 (COX-2) DMR3Q82 MT DTT DMR3Q82 MA Inhibitor DMR3Q82 RN Apricoxib, a COX-2 inhibitor for the potential treatment of pain and cancer. IDrugs. 2009 Nov;12(11):711-22. DMR3Q82 RU https://pubmed.ncbi.nlm.nih.gov/19844858 DMML5WB DI DMML5WB DMML5WB DN AR-D-111421 DMML5WB MI TTZC9FV DMML5WB MN Vasoactive intestinal polypeptide receptor (VIPR) DMML5WB MT DTT DMML5WB MA Modulator DMML5WB RN Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800013264) DMML5WB RU http://adisinsight.springer.com/drugs/800013264 DMBTG8J DI DMBTG8J DMBTG8J DN AR-H047108 DMBTG8J MI TTLOKXP DMBTG8J MN Gastric H(+)/K(+) ATPase (Proton pump) DMBTG8J MT DTT DMBTG8J MA Modulator DMBTG8J RN Early stellate cell activation and veno-occlusive-disease (VOD)-like hepatotoxicity in dogs treated with AR-H047108, an imidazopyridine proton pump inhibitor.Toxicol Pathol.2008 Jul;36(5):727-37. DMBTG8J RU https://www.ncbi.nlm.nih.gov/pubmed/18648100 DMNGQM0 DI DMNGQM0 DMNGQM0 DN Arm036 DMNGQM0 MI TTU5CIX DMNGQM0 MN Ryanodine receptor 1 (RYR1) DMNGQM0 MT DTT DMNGQM0 MA Modulator DMNGQM0 RN The Ryanodine Receptor Stabilizer S44121 / Arm036 Improves Peripheral and Respiratory Muscle Function in a Mouse Model of Heart Failure. Circulation. 2014; 130: A13726. DMNGQM0 RU http://circ.ahajournals.org/content/130/Suppl_2/A13726.abstract DMS0LCZ DI DMS0LCZ DMS0LCZ DN ARX-201 DMS0LCZ MI TTT3YKH DMS0LCZ MN Somatotropin (GH1) DMS0LCZ MT DTT DMS0LCZ MA Modulator DMS0LCZ RN Company report (Avarx) DMS0LCZ RU http://www.avarx.com/search/showOpportunityDetails?asset_id=1309 DMC2WI7 DI DMC2WI7 DMC2WI7 DN AS-35 DMC2WI7 MI TTGKOY9 DMC2WI7 MN Leukotriene CysLT1 receptor (CYSLTR1) DMC2WI7 MT DTT DMC2WI7 MA Modulator DMC2WI7 RN Inhibition of radiolabeled leukotriene-binding by AS-35 in guinea pig lung membrane fraction. Jpn J Pharmacol. 1992 Apr;58(4):357-64. DMC2WI7 RU https://www.ncbi.nlm.nih.gov/pubmed/1405033 DMC2WI7 DI DMC2WI7 DMC2WI7 DN AS-35 DMC2WI7 MI TT0PZR5 DMC2WI7 MN Leukotriene CysLT2 receptor (CYSLTR2) DMC2WI7 MT DTT DMC2WI7 MA Modulator DMC2WI7 RN Inhibition of radiolabeled leukotriene-binding by AS-35 in guinea pig lung membrane fraction. Jpn J Pharmacol. 1992 Apr;58(4):357-64. DMC2WI7 RU https://www.ncbi.nlm.nih.gov/pubmed/1405033 DM10XWU DI DM10XWU DM10XWU DN Atipamezole DM10XWU MI TTQ8AFT DM10XWU MN Adrenergic receptor Alpha-2 (ADRA2) DM10XWU MT DTT DM10XWU MA Antagonist DM10XWU RN Low doses of alpha 2-adrenoceptor antagonists augment spinal morphine analgesia and inhibit development of acute and chronic tolerance. Br J Pharmacol. 2008 Dec;155(8):1264-78. DM10XWU RU https://pubmed.ncbi.nlm.nih.gov/18806811 DMZEMG6 DI DMZEMG6 DMZEMG6 DN Atiratecan DMZEMG6 MI TTGTQHC DMZEMG6 MN DNA topoisomerase I (TOP1) DMZEMG6 MT DTT DMZEMG6 MA Inhibitor DMZEMG6 RN Method development and validation of the simultaneous determination of a novel topoisomerase 1 inhibitor, the prodrug, and the active metabolite in human plasma using column-switching LC-MS/MS, and its application in a clinical trial. J Chromatogr B Analyt Technol Biomed Life Sci. 2011 Nov 15;879(30):3415-22. DMZEMG6 RU https://pubmed.ncbi.nlm.nih.gov/21975380 DM7OE9F DI DM7OE9F DM7OE9F DN Atocalcitol DM7OE9F MI TTK59TV DM7OE9F MN Vitamin D3 receptor (VDR) DM7OE9F MT DTT DM7OE9F MA Agonist DM7OE9F RN Elocalcitol, a vitamin D3 analog for the potential treatment of benign prostatic hyperplasia, overactive bladder and male infertility. IDrugs. 2009 Jun;12(6):381-93. DM7OE9F RU https://pubmed.ncbi.nlm.nih.gov/19517319 DMWJ245 DI DMWJ245 DMWJ245 DN ATX-201 DMWJ245 MI TTML2WA DMWJ245 MN Tubulin (TUB) DMWJ245 MT DTT DMWJ245 MA Inhibitor DMWJ245 RN Clinical pipeline report, company report or official report of Kythera Biopharmaceuticals. DMWJ245 RU http://www.kythera.com/kythera-biopharmaceuticals-announces-discontinuation-of-actinic-keratosis-clinical-program/ DMWA957 DI DMWA957 DMWA957 DN Avarofloxacin DMWA957 MI TTIXTO3 DMWA957 MN Staphylococcus Topoisomerase IV (Stap-coc parC) DMWA957 MT DTT DMWA957 MA Modulator DMWA957 RN Antistaphylococcal activities of the new fluoroquinolone JNJ-Q2. Antimicrob Agents Chemother. 2011 Dec;55(12):5512-21. DMWA957 RU https://pubmed.ncbi.nlm.nih.gov/21911562 DMRYK1C DI DMRYK1C DMRYK1C DN AVE-0847 DMRYK1C MI TTJ584C DMRYK1C MN Peroxisome proliferator-activated receptor alpha (PPARA) DMRYK1C MT DTT DMRYK1C MA Modulator DMRYK1C RN DOI: 10.1038/scibx.2012.669 DMRYK1C RU http://www.nature.com/scibx/journal/v5/n26/fig_tab/scibx.2012.669_T1.html DMRYK1C DI DMRYK1C DMRYK1C DN AVE-0847 DMRYK1C MI TTZMAO3 DMRYK1C MN Peroxisome proliferator-activated receptor gamma (PPAR-gamma) DMRYK1C MT DTT DMRYK1C MA Modulator DMRYK1C RN DOI: 10.1038/scibx.2012.669 DMRYK1C RU http://www.nature.com/scibx/journal/v5/n26/fig_tab/scibx.2012.669_T1.html DMXNK0J DI DMXNK0J DMXNK0J DN AVE1625 DMXNK0J MI TT6OEDT DMXNK0J MN Cannabinoid receptor 1 (CB1) DMXNK0J MT DTT DMXNK0J MA Antagonist DMXNK0J RN Pharma & Vaccines. Product Development Pipeline. April 29 2009. DMXNK0J RU http://en.sanofi-aventis.com/binaries/RD_Phase_III_EN_tcm28-24007.pdf DMUQ6IL DI DMUQ6IL DMUQ6IL DN AVE-1642 DMUQ6IL MI TTHRID2 DMUQ6IL MN Insulin-like growth factor I receptor (IGF1R) DMUQ6IL MT DTT DMUQ6IL RN Insulin-like growth factor-1 receptor inhibition induces a resistance mechanism via the epidermal growth factor receptor/HER3/AKT signaling pathway: rational basis for cotargeting insulin-like growthfactor-1 receptor and epidermal growth factor receptor in hepatocellular carcinoma. Clin Cancer Res. 2009 Sep 1;15(17):5445-56. DMUQ6IL RU https://pubmed.ncbi.nlm.nih.gov/19706799 DMCX6MD DI DMCX6MD DMCX6MD DN AVE-8134 DMCX6MD MI TTJ584C DMCX6MD MN Peroxisome proliferator-activated receptor alpha (PPARA) DMCX6MD MT DTT DMCX6MD MA Agonist DMCX6MD RN The peroxisome proliferator-activated receptor-alpha (PPAR-alpha) agonist, AVE8134, attenuates the progression of heart failure and increases survival in rats. Acta Pharmacol Sin. 2009 Jul;30(7):935-46. DMCX6MD RU https://pubmed.ncbi.nlm.nih.gov/19503102 DMFCOZL DI DMFCOZL DMFCOZL DN AVN 397 DMFCOZL MI TTJS8PY DMFCOZL MN 5-HT 6 receptor (HTR6) DMFCOZL MT DTT DMFCOZL MA Antagonist DMFCOZL RN Latrepirdine, a potential novel treatment for Alzheimer's disease and Huntington's chorea. Curr Opin Investig Drugs. 2010 January; 11(1): 80-91. DMFCOZL RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3346261/ DM2I8NT DI DM2I8NT DM2I8NT DN Avosentan DM2I8NT MI TTKRD0G DM2I8NT MN Endothelin A receptor (EDNRA) DM2I8NT MT DTT DM2I8NT MA Antagonist DM2I8NT RN Agents in development for the treatment of diabetic nephropathy. Expert Opin Emerg Drugs. 2008 Sep;13(3):447-63. DM2I8NT RU https://pubmed.ncbi.nlm.nih.gov/18764722 DM8NA4M DI DM8NA4M DM8NA4M DN AVT-02 UE DM8NA4M MI TTN7R6K DM8NA4M MN Signal transducer and activator of transcription 1 (STAT1) DM8NA4M MT DTT DM8NA4M MA Inhibitor DM8NA4M RN Avontec Announces Results of a Multiple Dose Clinical Phase I Study with Its Drug Candidate AVT-02 UE Ointment After Topical Treatment in Male Healthy Volunteers. Avontec. 2008. DM8NA4M RU http://www.drugs.com/clinical_trials/avontec-announces-results-multiple-clinical-phase-study-candidate-avt-02-ue-ointment-after-topical-4866.html DMV1ES3 DI DMV1ES3 DMV1ES3 DN AZALANSTAT DMV1ES3 MI TTTSOUD DMV1ES3 MN Candida Cytochrome P450 51 (Candi ERG11) DMV1ES3 MT DTT DMV1ES3 MA Modulator DMV1ES3 RN Azalanstat (RS-21607), a lanosterol 14 alpha-demethylase inhibitor with cholesterol-lowering activity. Biochem Pharmacol. 1995 Aug 8;50(4):529-44. DMV1ES3 RU https://www.ncbi.nlm.nih.gov/pubmed/7646560 DM4B7CM DI DM4B7CM DM4B7CM DN AZD0328 DM4B7CM MI TTLA931 DM4B7CM MN Neuronal acetylcholine receptor alpha-7 (CHRNA7) DM4B7CM MT DTT DM4B7CM MA Modulator DM4B7CM RN Ultra-low exposure to -7 nicotinic acetylcholine receptor partial agonists elicits an improvement in cognition that corresponds with an increase in -7 receptor expression in rodents: implications for low dose clinical efficacy.Neuroscience.2011 Jul 14;186:76-87. DM4B7CM RU https://www.ncbi.nlm.nih.gov/pubmed/21550383 DMA9Q2V DI DMA9Q2V DMA9Q2V DN AZD0837 DMA9Q2V MI TT6L509 DMA9Q2V MN Coagulation factor IIa (F2) DMA9Q2V MT DTT DMA9Q2V MA Inhibitor DMA9Q2V RN Clinical pipeline report, company report or official report of AstraZeneca (2009). DMA9Q2V RU http://www.astrazeneca.com/_mshost3690701/content/resources/media/investors/AZN-Q2-2009/AZN-Q2-2009-Pipeline.pdf DML3RSF DI DML3RSF DML3RSF DN AZD1236 DML3RSF MI TTXZ0KQ DML3RSF MN Matrix metalloproteinase-12 (MMP-12) DML3RSF MT DTT DML3RSF MA Inhibitor DML3RSF RN Clinical pipeline report, company report or official report of AstraZeneca (2009). DML3RSF RU http://www.astrazeneca.com/_mshost3690701/content/resources/media/investors/AZN-Q2-2009/AZN-Q2-2009-Pipeline.pdf DMFAG8W DI DMFAG8W DMFAG8W DN AZD1386 DMFAG8W MI TTMI6F5 DMFAG8W MN Transient receptor potential cation channel V1 (TRPV1) DMFAG8W MT DTT DMFAG8W MA Blocker DMFAG8W RN Clinical pipeline report, company report or official report of AstraZeneca (2009). DMFAG8W RU http://www.astrazeneca.com/_mshost3690701/content/resources/media/investors/AZN-Q2-2009/AZN-Q2-2009-Pipeline.pdf DMHP6OY DI DMHP6OY DMHP6OY DN AZD2066 DMHP6OY MI TTHS256 DMHP6OY MN Metabotropic glutamate receptor 5 (mGluR5) DMHP6OY MT DTT DMHP6OY MA Antagonist DMHP6OY RN Clinical pipeline report, company report or official report of AstraZeneca (2009). DMHP6OY RU http://www.astrazeneca.com/_mshost3690701/content/resources/media/investors/AZN-Q2-2009/AZN-Q2-2009-Pipeline.pdf DM1TDWI DI DM1TDWI DM1TDWI DN AZD2207 DM1TDWI MI TT6OEDT DM1TDWI MN Cannabinoid receptor 1 (CB1) DM1TDWI MT DTT DM1TDWI MA Antagonist DM1TDWI RN Clinical pipeline report, company report or official report of AstraZeneca (2009). DM1TDWI RU http://www.astrazeneca.com/_mshost3690701/content/resources/media/investors/AZN-Q2-2009/AZN-Q2-2009-Pipeline.pdf DM9OPDE DI DM9OPDE DM9OPDE DN AZD2516 DM9OPDE MI TTHS256 DM9OPDE MN Metabotropic glutamate receptor 5 (mGluR5) DM9OPDE MT DTT DM9OPDE MA Antagonist DM9OPDE RN Clinical pipeline report, company report or official report of AstraZeneca (2009). DM9OPDE RU http://www.astrazeneca.com/_mshost3690701/content/resources/media/investors/AZN-Q2-2009/AZN-Q2-2009-Pipeline.pdf DMT5ZK3 DI DMT5ZK3 DMT5ZK3 DN AZD3355 DMT5ZK3 MI TTDCVZW DMT5ZK3 MN Gamma-aminobutyric acid B receptor (GABBR) DMT5ZK3 MT DTT DMT5ZK3 MA Modulator DMT5ZK3 RN Efficacy and safety of lesogaberan in gastro-oesophageal reflux disease: a randomised controlled trial.Gut.2013 Sep;62(9):1248-55. DMT5ZK3 RU https://www.ncbi.nlm.nih.gov/pubmed/22730470 DM4K085 DI DM4K085 DM4K085 DN AZD-3778 DM4K085 MI TTQR8Z6 DM4K085 MN Chemokine receptor (CHR) DM4K085 MT DTT DM4K085 MA Modulator DM4K085 RN New Drugs and Targets for Asthma and COPD. Trevor T. Hansel, Peter J. Barnes. 2010. Page(304). DM4K085 RU https://books.google.com.hk/books?id=aHipG471tVgC&pg=PT318&lpg=PT318&dq=%22AZD-3778%22&source=bl&ots=y_RqGG2ANK&sig=reQ4tfDvvdsUNpDF8vYyquoyO9Q&hl=zh-CN&sa=X&ved=0CD0Q6AEwBGoVChMI98D7zdG_yAIVSBiOCh0hpweg#v=onepage&q=%22AZD-3778%22&f=false DM3VFKM DI DM3VFKM DM3VFKM DN AZD4818 DM3VFKM MI TTC24WT DM3VFKM MN C-C chemokine receptor type 1 (CCR1) DM3VFKM MT DTT DM3VFKM MA Antagonist DM3VFKM RN Clinical pipeline report, company report or official report of AstraZeneca (2009). DM3VFKM RU http://www.astrazeneca.com/_mshost3690701/content/resources/media/investors/AZN-Q2-2009/AZN-Q2-2009-Pipeline.pdf DME8KQW DI DME8KQW DME8KQW DN AZD-5423 DME8KQW MI TTYRL6O DME8KQW MN Glucocorticoid receptor (NR3C1) DME8KQW MT DTT DME8KQW MA Agonist DME8KQW RN A nonsteroidal glucocorticoid receptor agonist inhibits allergen-induced late asthmatic responses. Am J Respir Crit Care Med. 2015 Jan 15;191(2):161-7. DME8KQW RU https://pubmed.ncbi.nlm.nih.gov/25473939 DMVZSRG DI DMVZSRG DMVZSRG DN AZD6370 DMVZSRG MI TTDLNGZ DMVZSRG MN Glucokinase (GCK) DMVZSRG MT DTT DMVZSRG MA Activator DMVZSRG RN Clinical pipeline report, company report or official report of AstraZeneca (2009). DMVZSRG RU http://www.astrazeneca.com/_mshost3690701/content/resources/media/investors/AZN-Q2-2009/AZN-Q2-2009-Pipeline.pdf DMHZ3DE DI DMHZ3DE DMHZ3DE DN AZD6765 DMHZ3DE MI TT9IK2Z DMHZ3DE MN N-methyl-D-aspartate receptor (NMDAR) DMHZ3DE MT DTT DMHZ3DE MA Antagonist DMHZ3DE RN Clinical pipeline report, company report or official report of AstraZeneca (2009). DMHZ3DE RU http://www.astrazeneca.com/_mshost3690701/content/resources/media/investors/AZN-Q2-2009/AZN-Q2-2009-Pipeline.pdf DMEQ2N1 DI DMEQ2N1 DMEQ2N1 DN AZD8529 DMEQ2N1 MI TTVBPDM DMEQ2N1 MN Metabotropic glutamate receptor 1 (mGluR1) DMEQ2N1 MT DTT DMEQ2N1 MA Agonist DMEQ2N1 RN Clinical pipeline report, company report or official report of AstraZeneca (2009). DMEQ2N1 RU http://www.astrazeneca.com/_mshost3690701/content/resources/media/investors/AZN-Q2-2009/AZN-Q2-2009-Pipeline.pdf DMHA5ME DI DMHA5ME DMHA5ME DN AZD-9684 DMHA5ME MI TTP18AY DMHA5ME MN Carboxypeptidase B2 (CPB2) DMHA5ME MT DTT DMHA5ME MA Inhibitor DMHA5ME RN Clinical pipeline report, company report or official report of AstraZeneca. DMHA5ME RU http://www.astrazeneca.com.au/research/cardiovascular?itemId=396161 DMHA5ME DI DMHA5ME DMHA5ME DN AZD-9684 DMHA5ME MI TTMT0HG DMHA5ME MN Neuronal acetylcholine receptor alpha-2/alpha-3 (CHRNA2/A3) DMHA5ME MT DTT DMHA5ME MA Antagonist DMHA5ME RN Blockade and activation of the human neuronal nicotinic acetylcholine receptors by atracurium and laudanosine. Anesthesiology. 2001 Apr;94(4):643-51. DMHA5ME RU https://pubmed.ncbi.nlm.nih.gov/11379686 DMHA5ME DI DMHA5ME DMHA5ME DN AZD-9684 DMHA5ME MI TTLA931 DMHA5ME MN Neuronal acetylcholine receptor alpha-7 (CHRNA7) DMHA5ME MT DTT DMHA5ME MA Antagonist DMHA5ME RN Blockade and activation of the human neuronal nicotinic acetylcholine receptors by atracurium and laudanosine. Anesthesiology. 2001 Apr;94(4):643-51. DMHA5ME RU https://pubmed.ncbi.nlm.nih.gov/11379686 DMHA5ME DI DMHA5ME DMHA5ME DN AZD-9684 DMHA5ME MI TT5KPZR DMHA5ME MN Neuronal acetylcholine receptor beta-2 (CHRNB2) DMHA5ME MT DTT DMHA5ME MA Antagonist DMHA5ME RN Blockade and activation of the human neuronal nicotinic acetylcholine receptors by atracurium and laudanosine. Anesthesiology. 2001 Apr;94(4):643-51. DMHA5ME RU https://pubmed.ncbi.nlm.nih.gov/11379686 DM04CIK DI DM04CIK DM04CIK DN AZT-P-DDI DM04CIK MI TT84ETX DM04CIK MN Human immunodeficiency virus Reverse transcriptase (HIV RT) DM04CIK MT DTT DM04CIK MA Inhibitor DM04CIK RN Antiviral activities of nucleotide heterodimers against human immunodeficiency virus type 1 in vitro. Antiviral Res. 1996 Jun;31(1-2):115-20. DM04CIK RU https://pubmed.ncbi.nlm.nih.gov/8793015 DM06JTL DI DM06JTL DM06JTL DN Balicatib DM06JTL MI TTDZN01 DM06JTL MN Cathepsin K (CTSK) DM06JTL MT DTT DM06JTL MA Inhibitor DM06JTL RN Current and future treatments of bone metastases. Expert Opin Emerg Drugs. 2008 Dec;13(4):609-27. DM06JTL RU https://pubmed.ncbi.nlm.nih.gov/19046130 DMPMKUF DI DMPMKUF DMPMKUF DN BAM-1110 DMPMKUF MI TTZFYLI DMPMKUF MN Dopamine D1 receptor (D1R) DMPMKUF MT DTT DMPMKUF MA Modulator DMPMKUF RN Therapeutic effects of dopamine D1/D2 receptor agonists on detrusor hyperreflexia in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-lesioned parkinso... J Pharmacol Exp Ther. 1998 Jul;286(1):228-33. DMPMKUF RU https://www.ncbi.nlm.nih.gov/pubmed/9655864 DMPMKUF DI DMPMKUF DMPMKUF DN BAM-1110 DMPMKUF MI TTEX248 DMPMKUF MN Dopamine D2 receptor (D2R) DMPMKUF MT DTT DMPMKUF MA Modulator DMPMKUF RN Therapeutic effects of dopamine D1/D2 receptor agonists on detrusor hyperreflexia in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-lesioned parkinso... J Pharmacol Exp Ther. 1998 Jul;286(1):228-33. DMPMKUF RU https://www.ncbi.nlm.nih.gov/pubmed/9655864 DMV2DIW DI DMV2DIW DMV2DIW DN BAY 10-00394 DMV2DIW MI TTH6V3D DMV2DIW MN Cyclin-dependent kinase 1 (CDK1) DMV2DIW MT DTT DMV2DIW MA Inhibitor DMV2DIW RN National Cancer Institute Drug Dictionary (drug id 770319). DMV2DIW RU http://www.cancer.gov/publications/dictionaries/cancer-drug?cdrid=770319 DMV2DIW DI DMV2DIW DMV2DIW DN BAY 10-00394 DMV2DIW MI TT7HF4W DMV2DIW MN Cyclin-dependent kinase 2 (CDK2) DMV2DIW MT DTT DMV2DIW MA Inhibitor DMV2DIW RN National Cancer Institute Drug Dictionary (drug id 770319). DMV2DIW RU http://www.cancer.gov/publications/dictionaries/cancer-drug?cdrid=770319 DMV2DIW DI DMV2DIW DMV2DIW DN BAY 10-00394 DMV2DIW MI TT0PG8F DMV2DIW MN Cyclin-dependent kinase 4 (CDK4) DMV2DIW MT DTT DMV2DIW MA Inhibitor DMV2DIW RN Liposarcoma: molecular genetics and therapeutics. Sarcoma. 2011;2011:483154. DMV2DIW RU https://pubmed.ncbi.nlm.nih.gov/21253554 DMV2DIW DI DMV2DIW DMV2DIW DN BAY 10-00394 DMV2DIW MI TT1LVF2 DMV2DIW MN Cyclin-dependent kinase 9 (CDK9) DMV2DIW MT DTT DMV2DIW MA Inhibitor DMV2DIW RN National Cancer Institute Drug Dictionary (drug id 770319). DMV2DIW RU http://www.cancer.gov/publications/dictionaries/cancer-drug?cdrid=770319 DMCZKG0 DI DMCZKG0 DMCZKG0 DN BAY-Y-3118 DMCZKG0 MI TTN6J5F DMCZKG0 MN Bacterial DNA gyrase (Bact gyrase) DMCZKG0 MT DTT DMCZKG0 MA Modulator DMCZKG0 RN Bay Y 3118, a new quinolone derivative, rapidly eradicates Listeria monocytogenes from infected mice and L929 cells. DMCZKG0 RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC284583 DMR569L DI DMR569L DMR569L DN BBR-3438 DMR569L MI TTUTN1I DMR569L MN Human Deoxyribonucleic acid (hDNA) DMR569L MT DTT DMR569L MA Binder DMR569L RN A novel 9-aza-anthrapyrazole effective against human prostatic carcinoma xenografts. Oncology. 2001;61(3):234-42. DMR569L RU https://pubmed.ncbi.nlm.nih.gov/11574780 DM6ANFC DI DM6ANFC DM6ANFC DN BCH-2687 DM6ANFC MI TTKWM86 DM6ANFC MN Opioid receptor mu (MOP) DM6ANFC MT DTT DM6ANFC MA Agonist DM6ANFC RN Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800009073) DM6ANFC RU http://adisinsight.springer.com/drugs/800009073 DMPIJE7 DI DMPIJE7 DMPIJE7 DN Becampanel DMPIJE7 MI TTAN6JD DMPIJE7 MN Glutamate receptor AMPA (GRIA) DMPIJE7 MT DTT DMPIJE7 MA Antagonist DMPIJE7 RN Emerging drugs for epilepsy. Expert Opin Emerg Drugs. 2007 Sep;12(3):407-22. DMPIJE7 RU https://pubmed.ncbi.nlm.nih.gov/17874969 DMEQL9U DI DMEQL9U DMEQL9U DN Benzydamine DMEQL9U MI DE6OQ3W DMEQL9U MN Cytochrome P450 1A1 (CYP1A1) DMEQL9U MT DME DMEQL9U MA Metabolism DMEQL9U RN In vitro evaluation of potential in vivo probes for human flavin-containing monooxygenase (FMO): metabolism of benzydamine and caffeine by FMO and P450 isoforms. Br J Clin Pharmacol. 2000 Oct;50(4):311-4. DMEQL9U RU https://www.ncbi.nlm.nih.gov/pubmed/?term=11012553 DMEQL9U DI DMEQL9U DMEQL9U DN Benzydamine DMEQL9U MI DEJGDUW DMEQL9U MN Cytochrome P450 1A2 (CYP1A2) DMEQL9U MT DME DMEQL9U MA Metabolism DMEQL9U RN Summary of information on human CYP enzymes: human P450 metabolism data. Drug Metab Rev. 2002 Feb-May;34(1-2):83-448. DMEQL9U RU https://www.ncbi.nlm.nih.gov/pubmed/?term=11996015 DMEQL9U DI DMEQL9U DMEQL9U DN Benzydamine DMEQL9U MI DECB0K3 DMEQL9U MN Cytochrome P450 2D6 (CYP2D6) DMEQL9U MT DME DMEQL9U MA Metabolism DMEQL9U RN In vitro evaluation of potential in vivo probes for human flavin-containing monooxygenase (FMO): metabolism of benzydamine and caffeine by FMO and P450 isoforms. Br J Clin Pharmacol. 2000 Oct;50(4):311-4. DMEQL9U RU https://www.ncbi.nlm.nih.gov/pubmed/?term=11012553 DMEQL9U DI DMEQL9U DMEQL9U DN Benzydamine DMEQL9U MI DEVDYN7 DMEQL9U MN Cytochrome P450 2E1 (CYP2E1) DMEQL9U MT DME DMEQL9U MA Metabolism DMEQL9U RN Characterization of moclobemide N-oxidation in human liver microsomes. Xenobiotica. 2001 Jul;31(7):387-97. DMEQL9U RU https://www.ncbi.nlm.nih.gov/pubmed/?term=11531003 DMEQL9U DI DMEQL9U DMEQL9U DN Benzydamine DMEQL9U MI DE4LYSA DMEQL9U MN Cytochrome P450 3A4 (CYP3A4) DMEQL9U MT DME DMEQL9U MA Metabolism DMEQL9U RN In vitro evaluation of potential in vivo probes for human flavin-containing monooxygenase (FMO): metabolism of benzydamine and caffeine by FMO and P450 isoforms. Br J Clin Pharmacol. 2000 Oct;50(4):311-4. DMEQL9U RU https://www.ncbi.nlm.nih.gov/pubmed/?term=11012553 DMEQL9U DI DMEQL9U DMEQL9U DN Benzydamine DMEQL9U MI DEGAZ8O DMEQL9U MN Dimethylaniline oxidase 4 (FMO4) DMEQL9U MT DME DMEQL9U MA Metabolism DMEQL9U RN In vitro evaluation of potential in vivo probes for human flavin-containing monooxygenase (FMO): metabolism of benzydamine and caffeine by FMO and P450 isoforms. Br J Clin Pharmacol. 2000 Oct;50(4):311-4. DMEQL9U RU https://www.ncbi.nlm.nih.gov/pubmed/?term=11012553 DMEQL9U DI DMEQL9U DMEQL9U DN Benzydamine DMEQL9U MI DEGTFWK DMEQL9U MN Mephenytoin 4-hydroxylase (CYP2C19) DMEQL9U MT DME DMEQL9U MA Metabolism DMEQL9U RN Characterization of moclobemide N-oxidation in human liver microsomes. Xenobiotica. 2001 Jul;31(7):387-97. DMEQL9U RU https://www.ncbi.nlm.nih.gov/pubmed/?term=11531003 DMEQL9U DI DMEQL9U DMEQL9U DN Benzydamine DMEQL9U MI TTK0943 DMEQL9U MN Prostaglandin G/H synthase (COX) DMEQL9U MT DTT DMEQL9U MA Inhibitor DMEQL9U RN Emerging drugs for chemotherapy-induced mucositis. Expert Opin Emerg Drugs. 2008 Sep;13(3):511-22. DMEQL9U RU https://pubmed.ncbi.nlm.nih.gov/18764726 DMEK6J0 DI DMEK6J0 DMEK6J0 DN Bervastatin DMEK6J0 MI TTPADOQ DMEK6J0 MN HMG-CoA reductase (HMGCR) DMEK6J0 MT DTT DMEK6J0 MA Inhibitor DMEK6J0 RN Effects of simvastatin, an HMG-CoA reductase inhibitor, in patients with hypertriglyceridemia. Clin Cardiol. 2003 Jan;26(1):18-24. DMEK6J0 RU https://pubmed.ncbi.nlm.nih.gov/12539808 DMTE3UV DI DMTE3UV DMTE3UV DN BI 1467335 DMTE3UV MI TT7HC21 DMTE3UV MN Membrane copper amine oxidase (AOC3) DMTE3UV MT DTT DMTE3UV MA Inhibitor DMTE3UV RN Clinical pipeline report, company report or official report of Boehringer Ingelheim. DMTE3UV RU https://www.boehringer-ingelheim.us/press-release/boehringer-ingelheim-discontinues-development-bi-1467335-diabetic-retinopathy DMGWFZJ DI DMGWFZJ DMGWFZJ DN BIBR-363 DMGWFZJ MI TTGN1ZA DMGWFZJ MN Angiotensin II receptor (AGTR) DMGWFZJ MT DTT DMGWFZJ MA Modulator DMGWFZJ RN Evaluation of the angiotensin challenge methodology for assessing the pharmacodynamic profile of antihypertensive drugs acting on the renin-angiotensin system. Br J Clin Pharmacol. 1999 October; 48(4): 594-604. DMGWFZJ RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2014379/ DMIZ59O DI DMIZ59O DMIZ59O DN BIM-23268 DMIZ59O MI TTOMNR9 DMIZ59O MN Somatostatin receptor (SSTR) DMIZ59O MT DTT DMIZ59O MA Modulator DMIZ59O RN Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41. DMIZ59O RU https://www.ncbi.nlm.nih.gov/pubmed/15950434 DMOP95G DI DMOP95G DMOP95G DN Bimoclomol DMOP95G MI TTHYBIX DMOP95G MN Heat shock protein 70 (HSP70) DMOP95G MT DTT DMOP95G MA Modulator DMOP95G RN Bimoclomol elevates heat shock protein 70 and cytoprotects rat neonatal cardiomyocytes. Eur J Pharmacol. 2002 Jan 18;435(1):73-7. DMOP95G RU https://pubmed.ncbi.nlm.nih.gov/11790380 DM65JCM DI DM65JCM DM65JCM DN Biricodar DM65JCM MI TT3OT40 DM65JCM MN Multidrug resistance protein 1 (ABCB1) DM65JCM MT DTT DM65JCM MA Modulator DM65JCM RN ClinicalTrials.gov (NCT00003847) VX-710, Doxorubicin, and Vincristine for the Treatment of Patients With Recurrent Small Cell Lung Cancer. U.S. National Institutes of Health. DM65JCM RU https://clinicaltrials.gov/ct2/show/NCT00003847 DMBIQL2 DI DMBIQL2 DMBIQL2 DN BISNAFIDE MESILATE DMBIQL2 MI TTUTN1I DMBIQL2 MN Human Deoxyribonucleic acid (hDNA) DMBIQL2 MT DTT DMBIQL2 MA Inhibitor DMBIQL2 RN DNA sequence recognition by bispyrazinonaphthalimides antitumor agents. Biochemistry. 2003 Oct 14;42(40):11751-61. DMBIQL2 RU https://pubmed.ncbi.nlm.nih.gov/14529286 DMQ6CYE DI DMQ6CYE DMQ6CYE DN BIWB-1 DMQ6CYE MI TTF89GD DMQ6CYE MN Interleukin-2 (IL2) DMQ6CYE MT DTT DMQ6CYE RN WO patent application no. 2013,1850,32, Nanotherapeutics for drug targeting. DMQ6CYE RU http://worldwide.espacenet.com/publicationDetails/biblio?DB=worldwide.espacenet.com&II=0&ND=3&adjacent=true&locale=en_EP&FT=D&date=20131212&CC=WO&NR=2013185032A1&KC=A1 DM7ZI8A DI DM7ZI8A DM7ZI8A DN BM-17.0744 DM7ZI8A MI TTJ584C DM7ZI8A MN Peroxisome proliferator-activated receptor alpha (PPARA) DM7ZI8A MT DTT DM7ZI8A MA Activator DM7ZI8A RN Cardiac function and metabolism in Type 2 diabetic mice after treatment with BM 17.0744, a novel PPAR-alpha activator. Am J Physiol Heart Circ Physiol. 2002 Sep;283(3):H949-57. DM7ZI8A RU https://pubmed.ncbi.nlm.nih.gov/12181123 DMVBGIT DI DMVBGIT DMVBGIT DN BMS-180448 DMVBGIT MI TT1VOHK DMVBGIT MN Potassium channel unspecific (KC) DMVBGIT MT DTT DMVBGIT MA Agonist DMVBGIT RN The novel cardioprotective agent BMS-180448 activates a potassium conductance in cardiac and vascular smooth muscle. Naunyn Schmiedebergs Arch Pharmacol. 1996 Oct;354(4):444-51. DMVBGIT RU https://pubmed.ncbi.nlm.nih.gov/8897447 DMT4VSE DI DMT4VSE DMT4VSE DN BMS-181101 DMT4VSE MI TT6MSOK DMT4VSE MN 5-HT 1D receptor (HTR1D) DMT4VSE MT DTT DMT4VSE MA Antagonist DMT4VSE RN Sensitive triple-quadrupole mass spectrometric assay for the determination of BMS-181885, a 5-HT1 agonist, in human plasma following solid phase extraction. Biomed Chromatogr. 1999 Oct;13(6):425-30. DMT4VSE RU https://pubmed.ncbi.nlm.nih.gov/10477901 DMT4VSE DI DMT4VSE DMT4VSE DN BMS-181101 DMT4VSE MI DECB0K3 DMT4VSE MN Cytochrome P450 2D6 (CYP2D6) DMT4VSE MT DME DMT4VSE MA Metabolism DMT4VSE RN Pharmacokinetic assessment of the sites of first-pass metabolism of BMS-181101, an antidepressant agent, in rats. J Pharm Pharmacol. 1998 Mar;50(3):275-8. DMT4VSE RU https://www.ncbi.nlm.nih.gov/pubmed/?term=9600718 DMT4VSE DI DMT4VSE DMT4VSE DN BMS-181101 DMT4VSE MI DE4LYSA DMT4VSE MN Cytochrome P450 3A4 (CYP3A4) DMT4VSE MT DME DMT4VSE MA Metabolism DMT4VSE RN Pharmacokinetic assessment of the sites of first-pass metabolism of BMS-181101, an antidepressant agent, in rats. J Pharm Pharmacol. 1998 Mar;50(3):275-8. DMT4VSE RU https://www.ncbi.nlm.nih.gov/pubmed/?term=9600718 DMGPHTJ DI DMGPHTJ DMGPHTJ DN BMS-181168 DMGPHTJ MI TTH18TF DMGPHTJ MN Muscarinic acetylcholine receptor M5 (CHRM5) DMGPHTJ MT DTT DMGPHTJ MA Modulator DMGPHTJ RN Efficacy and safety of BMY 21,502 in Alzheimer disease. Ann Pharmacother. 1996 Dec;30(12):1376-80. DMGPHTJ RU https://pubmed.ncbi.nlm.nih.gov/8968446 DMP8SIV DI DMP8SIV DMP8SIV DN BMS-187745 DMP8SIV MI TTFQEO5 DMP8SIV MN Squalene synthetase (FDFT1) DMP8SIV MT DTT DMP8SIV MA Inhibitor DMP8SIV RN Phosphonosulfonates are potent, selective inhibitors of dehydrosqualene synthase and staphyloxanthin biosynthesis in Staphylococcus aureus. J Med Chem. 2009 Feb 26;52(4):976-88. DMP8SIV RU https://pubmed.ncbi.nlm.nih.gov/19191557 DMODK2J DI DMODK2J DMODK2J DN BMS-193884 DMODK2J MI TTKRD0G DMODK2J MN Endothelin A receptor (EDNRA) DMODK2J MT DTT DMODK2J MA Modulator DMODK2J RN Vasodilator effects of the endothelin ETA receptor selective antagonist BMS-193884 in healthy men DMODK2J RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1884878 DMRPU10 DI DMRPU10 DMRPU10 DN BMS-488043 DMRPU10 MI DE4LYSA DMRPU10 MN Cytochrome P450 3A4 (CYP3A4) DMRPU10 MT DME DMRPU10 MA Metabolism DMRPU10 RN Antiviral activity, pharmacokinetics, and safety of BMS-488043, a novel oral small-molecule HIV-1 attachment inhibitor, in HIV-1-infected subjects. Antimicrob Agents Chemother. 2011 Feb;55(2):722-8. DMRPU10 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=21078951 DMRPU10 DI DMRPU10 DMRPU10 DN BMS-488043 DMRPU10 MI TTBYP1X DMRPU10 MN Human immunodeficiency virus Envelope glycoprotein gp120 (HIV gp120) DMRPU10 MT DTT DMRPU10 MA Modulator DMRPU10 RN The investigations on HIV-1 gp120 bound with BMS-488043 by using docking and molecular dynamics simulations.J Mol Model.2013 Feb;19(2):905-17. DMRPU10 RU https://www.ncbi.nlm.nih.gov/pubmed/23086459 DMS2IC9 DI DMS2IC9 DMS2IC9 DN BMS-587101 DMS2IC9 MI TT48WR6 DMS2IC9 MN Integrin alpha-L (ITGAL) DMS2IC9 MT DTT DMS2IC9 MA Inhibitor DMS2IC9 RN Small molecule antagonist of leukocyte function associated antigen-1 (LFA-1): structure-activity relationships leading to the identification of 6-(... J Med Chem. 2010 May 13;53(9):3814-30. DMS2IC9 RU https://pubmed.ncbi.nlm.nih.gov/20405922 DMS2IC9 DI DMS2IC9 DMS2IC9 DN BMS-587101 DMS2IC9 MI TTIJWR7 DMS2IC9 MN Integrin beta-2 (ITGB2) DMS2IC9 MT DTT DMS2IC9 MA Inhibitor DMS2IC9 RN Discovery and development of 5-[(5S,9R)-9-(4-cyanophenyl)-3-(3,5-dichlorophenyl)-1-methyl-2,4-dioxo-1,3,7-triazaspiro[4.4]non-7-yl-methyl]-3-thioph... J Med Chem. 2006 Nov 30;49(24):6946-9. DMS2IC9 RU https://pubmed.ncbi.nlm.nih.gov/17125246 DM2NBXR DI DM2NBXR DM2NBXR DN BMY-21950 DM2NBXR MI TTPADOQ DM2NBXR MN HMG-CoA reductase (HMGCR) DM2NBXR MT DTT DM2NBXR MA Inhibitor DM2NBXR RN Selective inhibition of cholesterol synthesis in liver versus extrahepatic tissues by HMG-CoA reductase inhibitors. J Lipid Res. 1990 Jul;31(7):1271-82. DM2NBXR RU https://pubmed.ncbi.nlm.nih.gov/2401858 DMMJDYI DI DMMJDYI DMMJDYI DN BMY-30123 DMMJDYI MI TTOD7B3 DMMJDYI MN Retinoic acid receptor (RAR) DMMJDYI MT DTT DMMJDYI MA Modulator DMMJDYI RN The pharmacology of a novel topical retinoid, BMY 30123: comparison with tretinoin. J Pharm Pharmacol. 1992 May;44(5):379-86. DMMJDYI RU https://pubmed.ncbi.nlm.nih.gov/1359051 DMA4UCP DI DMA4UCP DMA4UCP DN BMY-30129 DMA4UCP MI TT9V5JH DMA4UCP MN Phospholipase A2 (PLA2G1B) DMA4UCP MT DTT DMA4UCP MA Inhibitor DMA4UCP RN Inhibitor of phospholipase A2 blocks eicosanoid and platelet activating factor biosynthesis and has topical anti-inflammatory activity. J Pharmacol Exp Ther. 1994 Nov;271(2):852-9. DMA4UCP RU https://pubmed.ncbi.nlm.nih.gov/7965805 DMC35T1 DI DMC35T1 DMC35T1 DN BN50727 DMC35T1 MI TTQL5VC DMC35T1 MN Platelet-activating factor receptor (PTAFR) DMC35T1 MT DTT DMC35T1 MA Modulator DMC35T1 RN Platelet-activating factor preferentially stimulates the phospholipase A2/cyclooxygenase cascade in the rabbit cornea. Curr Eye Res. 1995 Sep;14(9):769-75. DMC35T1 RU https://www.ncbi.nlm.nih.gov/pubmed/8529415 DMK0PVC DI DMK0PVC DMK0PVC DN BOF-4272 DMK0PVC MI TT7RJY8 DMK0PVC MN Xanthine dehydrogenase/oxidase (XDH) DMK0PVC MT DTT DMK0PVC MA Inhibitor DMK0PVC RN Enantioselective uptake of BOF-4272, a xanthine oxidase inhibitor with a chiral sulfoxide, by isolated rat hepatocytes. Yakugaku Zasshi. 2001 Dec;121(12):989-94. DMK0PVC RU https://pubmed.ncbi.nlm.nih.gov/11766411 DMI3T64 DI DMI3T64 DMI3T64 DN BP-2.94 DMI3T64 MI TT9JNIC DMI3T64 MN Histamine H3 receptor (H3R) DMI3T64 MT DTT DMI3T64 MA Modulator DMI3T64 RN Sleep and waking during acute histamine H3 agonist BP 2.94 or H3 antagonist carboperamide (MR 16155) administration in rats. Neuropsychopharmacology. 1996 Jul;15(1):31-5. DMI3T64 RU https://pubmed.ncbi.nlm.nih.gov/8797189 DMAQ6DS DI DMAQ6DS DMAQ6DS DN BP-897 DMAQ6DS MI TT4C8EA DMAQ6DS MN Dopamine D3 receptor (D3R) DMAQ6DS MT DTT DMAQ6DS MA Modulator DMAQ6DS RN BP 897, a selective dopamine D3 receptor ligand with therapeutic potential for the treatment of cocaine-addiction.CNS Drug Rev.2003 Summer;9(2):141-58. DMAQ6DS RU https://www.ncbi.nlm.nih.gov/pubmed/12847556 DMFN1WI DI DMFN1WI DMFN1WI DN BR3-Fc DMFN1WI MI TTWMIDN DMFN1WI MN B-cell-activating factor (TNFSF13B) DMFN1WI MT DTT DMFN1WI MA Inhibitor DMFN1WI RN Emerging drugs for idiopathic thrombocytopenic purpura in adults. Expert Opin Emerg Drugs. 2008 Jun;13(2):237-54. DMFN1WI RU https://pubmed.ncbi.nlm.nih.gov/18537519 DMRVH2S DI DMRVH2S DMRVH2S DN Brecanavir DMRVH2S MI TT5FNQT DMRVH2S MN Human immunodeficiency virus Protease (HIV PR) DMRVH2S MT DTT DMRVH2S MA Modulator DMRVH2S RN Safety and pharmacokinetics of brecanavir, a novel human immunodeficiency virus type 1 protease inhibitor, following repeat administration with and without ritonavir in healthy adult subjects.Antimicrob Agents Chemother.2007 Apr;51(4):1202-8. DMRVH2S RU https://www.ncbi.nlm.nih.gov/pubmed/17261626 DMRKBIU DI DMRKBIU DMRKBIU DN BRL-32872A DMRKBIU MI TT5HONZ DMRKBIU MN Calcium channel unspecific (CaC) DMRKBIU MT DTT DMRKBIU MA Modulator DMRKBIU RN Combined potassium and calcium channel blocking activities as a basis for antiarrhythmic efficacy with low proarrhythmic risk: experimental profile... J Pharmacol Exp Ther. 1996 Feb;276(2):637-46. DMRKBIU RU https://www.ncbi.nlm.nih.gov/pubmed/8632331 DMRKBIU DI DMRKBIU DMRKBIU DN BRL-32872A DMRKBIU MI TT1VOHK DMRKBIU MN Potassium channel unspecific (KC) DMRKBIU MT DTT DMRKBIU MA Modulator DMRKBIU RN Combined potassium and calcium channel blocking activities as a basis for antiarrhythmic efficacy with low proarrhythmic risk: experimental profile... J Pharmacol Exp Ther. 1996 Feb;276(2):637-46. DMRKBIU RU https://www.ncbi.nlm.nih.gov/pubmed/8632331 DMIHSOG DI DMIHSOG DMIHSOG DN BRL-46470 DMIHSOG MI TTNXLKE DMIHSOG MN 5-HT 3 receptor (5HT3R) DMIHSOG MT DTT DMIHSOG MA Modulator DMIHSOG RN Evidence that the atypical 5-HT3 receptor ligand, [3H]-BRL46470, labels additional 5-HT3 binding sites compared to [3H]-granisetron. Br J Pharmacol. 1995 Sep;116(2):1781-8. DMIHSOG RU https://www.ncbi.nlm.nih.gov/pubmed/8528560 DM0WG4U DI DM0WG4U DM0WG4U DN BRL-55834 DM0WG4U MI TT1VOHK DM0WG4U MN Potassium channel unspecific (KC) DM0WG4U MT DTT DM0WG4U MA Opener DM0WG4U RN Comparison of the airways relaxant and hypotensive potencies of the potassium channel activators BRL 55834 and levcromakalim (BRL 38227) in vivo in guinea-pigs and rats. Br J Pharmacol. 1993 Aug;109(4):1133-9. DM0WG4U RU https://pubmed.ncbi.nlm.nih.gov/8401925 DMV3Y8R DI DMV3Y8R DMV3Y8R DN BRL-61063 DMV3Y8R MI TTK25J1 DMV3Y8R MN Adenosine A1 receptor (ADORA1) DMV3Y8R MT DTT DMV3Y8R MA Inhibitor DMV3Y8R RN Inhibition of cyclic nucleotide phosphodiesterase by derivatives of 1,3-bis(cyclopropylmethyl)xanthine. J Med Chem. 1994 Feb 18;37(4):476-85. DMV3Y8R RU https://pubmed.ncbi.nlm.nih.gov/8120866 DMV3Y8R DI DMV3Y8R DMV3Y8R DN BRL-61063 DMV3Y8R MI TTJ0IQB DMV3Y8R MN Phosphodiesterase 5A (PDE5A) DMV3Y8R MT DTT DMV3Y8R MA Inhibitor DMV3Y8R RN Inhibition of cyclic nucleotide phosphodiesterase by derivatives of 1,3-bis(cyclopropylmethyl)xanthine. J Med Chem. 1994 Feb 18;37(4):476-85. DMV3Y8R RU https://pubmed.ncbi.nlm.nih.gov/8120866 DMTEQ0G DI DMTEQ0G DMTEQ0G DN Brofaromine DMTEQ0G MI DECB0K3 DMTEQ0G MN Cytochrome P450 2D6 (CYP2D6) DMTEQ0G MT DME DMTEQ0G MA Metabolism DMTEQ0G RN Role of cytochrome P4502D6 in the metabolism of brofaromine. A new selective MAO-A inhibitor. Eur J Clin Pharmacol. 1993;45(3):265-9. DMTEQ0G RU https://www.ncbi.nlm.nih.gov/pubmed/?term=8276052 DMTEQ0G DI DMTEQ0G DMTEQ0G DN Brofaromine DMTEQ0G MI TT3WG5C DMTEQ0G MN Monoamine oxidase type A (MAO-A) DMTEQ0G MT DTT DMTEQ0G MA Modulator DMTEQ0G RN Preclinical profiles of the novel reversible MAO-A inhibitors, moclobemide and brofaromine, in comparison with irreversible MAO inhibitors. J Neural Transm Suppl. 1989;28:5-20. DMTEQ0G RU https://pubmed.ncbi.nlm.nih.gov/2677242 DM54K2P DI DM54K2P DM54K2P DN BTS-67582 DM54K2P MI TTEF5MJ DM54K2P MN ATP-binding cassette transporter C9 (ABCC9) DM54K2P MT DTT DM54K2P MA Modulator DM54K2P RN BTS-67582 (Knoll Pharmaceuticals Co). IDrugs. 1999 Apr;2(4):355-9. DM54K2P RU https://www.ncbi.nlm.nih.gov/pubmed/16158354 DM43JK0 DI DM43JK0 DM43JK0 DN BVT-115959 DM43JK0 MI TTM2AOE DM43JK0 MN Adenosine A2a receptor (ADORA2A) DM43JK0 MT DTT DM43JK0 MA Agonist DM43JK0 RN Recent developments in adenosine receptor ligands and their potential as novel drugs. Biochim Biophys Acta. 2011 May;1808(5):1290-308. DM43JK0 RU https://pubmed.ncbi.nlm.nih.gov/21185259 DMI2LFG DI DMI2LFG DMI2LFG DN BW-773U82 DMI2LFG MI TT0IHXV DMI2LFG MN DNA topoisomerase II (TOP2) DMI2LFG MT DTT DMI2LFG MA Modulator DMI2LFG RN Correlation of cytotoxicity and protein-associated DNA strand breaks for 2-(arylmethylamino)-1,3-propanediols. Anticancer Drug Des. 1998 Oct;13(7):825-35. DMI2LFG RU https://pubmed.ncbi.nlm.nih.gov/9807165 DM8ZFS3 DI DM8ZFS3 DM8ZFS3 DN BY-1949 DM8ZFS3 MI TT5WKM8 DM8ZFS3 MN ATP phosphatase (ATPase) DM8ZFS3 MT DTT DM8ZFS3 MA Modulator DM8ZFS3 RN An activation of synaptosomal Na+,K(+)-ATPase by a novel dibenzoxazepine derivative (BY-1949) in the rat brain: its functional role in the neurotransmitter uptake systems. J Neurochem. 1992 Jan;58(1):362-8. DM8ZFS3 RU https://pubmed.ncbi.nlm.nih.gov/1345768 DMHJ3SN DI DMHJ3SN DMHJ3SN DN Cadrofloxacin DMHJ3SN MI TTN6J5F DMHJ3SN MN Bacterial DNA gyrase (Bact gyrase) DMHJ3SN MT DTT DMHJ3SN MA Modulator DMHJ3SN RN Hydrophilicity of quinolones is not an exclusive factor for decreased activity in efflux-mediated resistant mutants of Staphylococcus aureus. Antimicrob Agents Chemother. 1996 Aug;40(8):1835-42. DMHJ3SN RU https://pubmed.ncbi.nlm.nih.gov/8843290 DMS3ECJ DI DMS3ECJ DMS3ECJ DN Camobucol DMS3ECJ MI TTF8CQI DMS3ECJ MN Tumor necrosis factor (TNF) DMS3ECJ MT DTT DMS3ECJ MA Inhibitor DMS3ECJ RN AGIX-4207 [2-[4-[[1-[[3,5-bis(1,1-dimethylethyl)-4-hydroxyphenyl]thio]-1-methylethyl]thio]-2,6-bis(1,1-dimethylethyl)phenoxy]acetic acid], a novel ... J Pharmacol Exp Ther. 2005 May;313(2):492-501. DMS3ECJ RU https://pubmed.ncbi.nlm.nih.gov/15701708 DMNOLHT DI DMNOLHT DMNOLHT DN Caracemide DMNOLHT MI TT1RS9F DMNOLHT MN Acetylcholinesterase (AChE) DMNOLHT MT DTT DMNOLHT MA Inhibitor DMNOLHT RN Biochemical pharmacology of N-acetyl-N-(methylcarbamoyloxy)-N'-methylurea (caracemide; NSC-253272). Biochem Pharmacol. 1986 Aug 15;35(16):2781-7. DMNOLHT RU https://pubmed.ncbi.nlm.nih.gov/3527174 DMV2DY3 DI DMV2DY3 DMV2DY3 DN CARIPORIDE DMV2DY3 MI TTGSEFH DMV2DY3 MN Sodium/hydrogen exchanger 1 (SLC9A1) DMV2DY3 MT DTT DMV2DY3 MA Inhibitor DMV2DY3 RN Synthesis and bioactivity of substituted indan-1-ylideneaminoguanidine derivatives. Eur J Med Chem. 2009 Sep;44(9):3771-6. DMV2DY3 RU https://pubmed.ncbi.nlm.nih.gov/19482383 DMV2DY3 DI DMV2DY3 DMV2DY3 DN CARIPORIDE DMV2DY3 MI TTFZVPO DMV2DY3 MN Sodium/hydrogen exchanger 3 (SLC9A3) DMV2DY3 MT DTT DMV2DY3 MA Inhibitor DMV2DY3 RN Bicyclic acylguanidine Na+/H+ antiporter inhibitors. J Med Chem. 1998 Sep 10;41(19):3736-47. DMV2DY3 RU https://pubmed.ncbi.nlm.nih.gov/9733499 DM5DI1G DI DM5DI1G DM5DI1G DN CARZELESIN DM5DI1G MI TTUTN1I DM5DI1G MN Human Deoxyribonucleic acid (hDNA) DM5DI1G MT DTT DM5DI1G MA Binder DM5DI1G RN Sequence selectivity of DNA alkylation by adozelesin and carzelesin. Arch Pharm Res. 1998 Aug;21(4):385-90. DM5DI1G RU https://pubmed.ncbi.nlm.nih.gov/9875464 DMPZFDE DI DMPZFDE DMPZFDE DN CASTANOSPERMINE DMPZFDE MI TTQRL1H DMPZFDE MN Glucosidase unspecific (GAN) DMPZFDE MT DTT DMPZFDE MA Modulator DMPZFDE RN Castanospermine inhibits alpha-glucosidase activities and alters glycogen distribution in animals. Proc Natl Acad Sci U S A. 1985 Jan;82(1):93-7. DMPZFDE RU https://pubmed.ncbi.nlm.nih.gov/3881759 DMVP4YK DI DMVP4YK DMVP4YK DN CB1954 DMVP4YK MI DEEHWOG DMVP4YK MN Azoreductase (azoR) DMVP4YK MT DME DMVP4YK MA Metabolism DMVP4YK RN Discovery and evaluation of Escherichia coli nitroreductases that activate the anti-cancer prodrug CB1954. Biochem Pharmacol. 2010 Mar 1;79(5):678-87. DMVP4YK RU https://pubmed.ncbi.nlm.nih.gov/19852945 DMVP4YK DI DMVP4YK DMVP4YK DN CB1954 DMVP4YK MI DE07EIQ DMVP4YK MN General stress protein 14 (ywrO) DMVP4YK MT DME DMVP4YK MA Metabolism DMVP4YK RN Bacillus amyloliquefaciens orthologue of Bacillus subtilis ywrO encodes a nitroreductase enzyme which activates the prodrug CB 1954. Microbiology. 2002 Jan;148(Pt 1):297-306. DMVP4YK RU https://pubmed.ncbi.nlm.nih.gov/11782522 DMVP4YK DI DMVP4YK DMVP4YK DN CB1954 DMVP4YK MI DE1FR8H DMVP4YK MN N-ethylmaleimide reductase (nemA) DMVP4YK MT DME DMVP4YK MA Metabolism DMVP4YK RN Discovery and evaluation of Escherichia coli nitroreductases that activate the anti-cancer prodrug CB1954. Biochem Pharmacol. 2010 Mar 1;79(5):678-87. DMVP4YK RU https://pubmed.ncbi.nlm.nih.gov/19852945 DMVP4YK DI DMVP4YK DMVP4YK DN CB1954 DMVP4YK MI DEDPI65 DMVP4YK MN Oxygen-insensitive NADPH nitroreductase A (nfsA) DMVP4YK MT DME DMVP4YK MA Metabolism DMVP4YK RN Discovery and evaluation of Escherichia coli nitroreductases that activate the anti-cancer prodrug CB1954. Biochem Pharmacol. 2010 Mar 1;79(5):678-87. DMVP4YK RU https://pubmed.ncbi.nlm.nih.gov/19852945 DMVP4YK DI DMVP4YK DMVP4YK DN CB1954 DMVP4YK MI DE0QLUZ DMVP4YK MN Oxygen-insensitive NADPH nitroreductase B (nfsB) DMVP4YK MT DME DMVP4YK MA Metabolism DMVP4YK RN Conversion of NfsB, a minor Escherichia coli nitroreductase, to a flavin reductase similar in biochemical properties to FRase I, the major flavin reductase in Vibrio fischeri, by a single amino acid substitution. J Bacteriol. 1996 Aug;178(15):4731-3. DMVP4YK RU https://pubmed.ncbi.nlm.nih.gov/8755909 DMVP4YK DI DMVP4YK DMVP4YK DN CB1954 DMVP4YK MI DENP5RY DMVP4YK MN Quinone reductase 1 (NQO1) DMVP4YK MT DME DMVP4YK MA Metabolism DMVP4YK RN Gene Therapy of the Central Nervous System. Charter 22 - Prodrug-Activation Gene Therapy. 2006, Pages 291-301 DMVP4YK RU https://www.sciencedirect.com/science/article/pii/B978012397632150023X DMVP4YK DI DMVP4YK DMVP4YK DN CB1954 DMVP4YK MI TTJLP0R DMVP4YK MN Quinone reductase 2 (NQO2) DMVP4YK MT DTT DMVP4YK MA Inhibitor DMVP4YK RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMVP4YK RU https://pubmed.ncbi.nlm.nih.gov/17139284 DM2FAH0 DI DM2FAH0 DM2FAH0 DN CBF-BS2 DM2FAH0 MI TTKN8W0 DM2FAH0 MN Glucose-6-phosphate dehydrogenase (G6PD) DM2FAH0 MT DTT DM2FAH0 MA Modulator DM2FAH0 RN Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800007279) DM2FAH0 RU http://adisinsight.springer.com/drugs/800007279 DM9P7Z2 DI DM9P7Z2 DM9P7Z2 DN CD-349 DM9P7Z2 MI TT5HONZ DM9P7Z2 MN Calcium channel unspecific (CaC) DM9P7Z2 MT DTT DM9P7Z2 MA Modulator DM9P7Z2 RN A new Ca-antagonist, CD-349, binding to the Ca-channel of rat myocardium and brain and hog coronary artery. Jpn J Pharmacol. 1988 Dec;48(4):453-62. DM9P7Z2 RU https://pubmed.ncbi.nlm.nih.gov/2854176 DMUPJW4 DI DMUPJW4 DMUPJW4 DN CDP840 DMUPJW4 MI TTZ97H5 DMUPJW4 MN Phosphodiesterase 4A (PDE4A) DMUPJW4 MT DTT DMUPJW4 MA Inhibitor DMUPJW4 RN Discovery of a substituted 8-arylquinoline series of PDE4 inhibitors: structure-activity relationship, optimization, and identification of a highly... Bioorg Med Chem Lett. 2005 Dec 1;15(23):5241-6. DMUPJW4 RU https://pubmed.ncbi.nlm.nih.gov/16168647 DMUPJW4 DI DMUPJW4 DMUPJW4 DN CDP840 DMUPJW4 MI TTVIAT9 DMUPJW4 MN Phosphodiesterase 4B (PDE4B) DMUPJW4 MT DTT DMUPJW4 MA Inhibitor DMUPJW4 RN Discovery of a substituted 8-arylquinoline series of PDE4 inhibitors: structure-activity relationship, optimization, and identification of a highly... Bioorg Med Chem Lett. 2005 Dec 1;15(23):5241-6. DMUPJW4 RU https://pubmed.ncbi.nlm.nih.gov/16168647 DMUPJW4 DI DMUPJW4 DMUPJW4 DN CDP840 DMUPJW4 MI TTSKMI8 DMUPJW4 MN Phosphodiesterase 4D (PDE4D) DMUPJW4 MT DTT DMUPJW4 MA Inhibitor DMUPJW4 RN Discovery of a substituted 8-arylquinoline series of PDE4 inhibitors: structure-activity relationship, optimization, and identification of a highly... Bioorg Med Chem Lett. 2005 Dec 1;15(23):5241-6. DMUPJW4 RU https://pubmed.ncbi.nlm.nih.gov/16168647 DMWHQM3 DI DMWHQM3 DMWHQM3 DN CDP-850 DMWHQM3 MI TTE5VG0 DMWHQM3 MN P-selectin (SELP) DMWHQM3 MT DTT DMWHQM3 RN WO patent application no. 2001,0276,21, Competitive inhibition elisa for antibody detection. DMWHQM3 RU http://www.google.com/patents/WO2001027621A2?cl=en DMEI0LJ DI DMEI0LJ DMEI0LJ DN CDP-860 DMEI0LJ MI TTI7421 DMEI0LJ MN Platelet-derived growth factor receptor beta (PDGFRB) DMEI0LJ MT DTT DMEI0LJ MA Modulator DMEI0LJ RN Blockade of platelet-derived growth factor receptor-beta by CDP860, a humanized, PEGylated di-Fab', leads to fluid accumulation and is associated w... J Clin Oncol. 2005 Feb 10;23(5):973-81. DMEI0LJ RU https://pubmed.ncbi.nlm.nih.gov/15466784 DM746L8 DI DM746L8 DM746L8 DN CE-1037 DM746L8 MI TTPLTSQ DM746L8 MN Neutrophil elastase (NE) DM746L8 MT DTT DM746L8 MA Inhibitor DM746L8 RN Neutrophil elastase inhibitors as treatment for COPD. Expert Opin Investig Drugs. 2002 Jul;11(7):965-80. DM746L8 RU https://pubmed.ncbi.nlm.nih.gov/12084007 DMXO49B DI DMXO49B DMXO49B DN CE-326597 DMXO49B MI TTCG0AL DMXO49B MN Cholecystokinin receptor type A (CCKAR) DMXO49B MT DTT DMXO49B MA Agonist DMXO49B RN Obesity Pharmacotherapy: Current Perspectives and Future Directions. Curr Cardiol Rev. 2013 February; 9(1): 33-54. DMXO49B RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3584306/ DMIR4FB DI DMIR4FB DMIR4FB DN CEMADOTIN HYDROCHLORIDE DMIR4FB MI TTYFKSZ DMIR4FB MN Tubulin beta (TUBB) DMIR4FB MT DTT DMIR4FB MA Modulator DMIR4FB RN Suppression of microtubule dynamics by binding of cemadotin to tubulin: possible mechanism for its antitumor action. Biochemistry. 1998 Dec 15;37(50):17571-8. DMIR4FB RU https://pubmed.ncbi.nlm.nih.gov/9860873 DMG62H1 DI DMG62H1 DMG62H1 DN CereCRIB DMG62H1 MI TTN4QDT DMG62H1 MN Opioid receptor (OPR) DMG62H1 MT DTT DMG62H1 MA Modulator DMG62H1 RN US patent application no. 5,874,099, Methods for making immunoisolatary implantable vehicles with a biocompatible jacket and a biocompatible matrix core. DMG62H1 RU http://www.google.co.ug/patents/US5874099 DMFBNI6 DI DMFBNI6 DMFBNI6 DN Ceronapril DMFBNI6 MI TTL69WB DMFBNI6 MN Angiotensin-converting enzyme (ACE) DMFBNI6 MT DTT DMFBNI6 MA Inhibitor DMFBNI6 RN Radioimmunoassay for ceronapril, a new angiotensin-converting enzyme inhibitor, and its application to a pharmacokinetic study in healthy male volunteers. Ther Drug Monit. 1992 Jun;14(3):209-19. DMFBNI6 RU https://pubmed.ncbi.nlm.nih.gov/1412607 DMFBNI6 DI DMFBNI6 DMFBNI6 DN Ceronapril DMFBNI6 MI DT9G7XN DMFBNI6 MN Peptide transporter 1 (SLC15A1) DMFBNI6 MT DTP DMFBNI6 MA Substrate DMFBNI6 RN Pharmaceutical and pharmacological importance of peptide transporters. J Pharm Pharmacol. 2008 May;60(5):543-85. DMFBNI6 RU https://doi.org/10.1211/jpp.60.5.0002 DMUG5OB DI DMUG5OB DMUG5OB DN CETi-1 DMUG5OB MI TTFQAYR DMUG5OB MN Cholesteryl ester transfer protein (CETP) DMUG5OB MT DTT DMUG5OB RN CETi-1. AVANT. Curr Opin Investig Drugs. 2004 Mar;5(3):334-8. DMUG5OB RU https://pubmed.ncbi.nlm.nih.gov/15083601 DMHK8IM DI DMHK8IM DMHK8IM DN CFC-222 DMHK8IM MI TTN6J5F DMHK8IM MN Bacterial DNA gyrase (Bact gyrase) DMHK8IM MT DTT DMHK8IM MA Modulator DMHK8IM RN Fluoroquinolone resistance in Mycoplasma gallisepticum: DNA gyrase as primary target of enrofloxacin and impact of mutations in topoisomerases on r... J Antimicrob Chemother. 2002 Oct;50(4):589-92. DMHK8IM RU https://www.ncbi.nlm.nih.gov/pubmed/12356806 DMBJQU6 DI DMBJQU6 DMBJQU6 DN CGP-49823 DMBJQU6 MI TTZPO1L DMBJQU6 MN Substance-P receptor (TACR1) DMBJQU6 MT DTT DMBJQU6 MA Antagonist DMBJQU6 RN The potency of the novel tachykinin receptor antagonist CGP49823 at rat and gerbil motoneurones in vitro. Eur J Pharmacol. 1998 Jan 26;342(2-3):203-8. DMBJQU6 RU https://pubmed.ncbi.nlm.nih.gov/9548386 DMCRPKS DI DMCRPKS DMCRPKS DN CGRP DMCRPKS MI TTAFORY DMCRPKS MN Calcitonin gene-related peptide (CALC) DMCRPKS MT DTT DMCRPKS MA Modulator DMCRPKS RN Calcitonin gene-related peptide as inflammatory mediator.Pulm Pharmacol Ther.2003;16(3):121-30. DMCRPKS RU https://www.ncbi.nlm.nih.gov/pubmed/12749828 DM2OWCV DI DM2OWCV DM2OWCV DN CGS-25462 DM2OWCV MI TT5TKPM DM2OWCV MN Neutral endopeptidase (MME) DM2OWCV MT DTT DM2OWCV MA Modulator DM2OWCV RN Quantitative analytical methods for the determination of a new hypertension drug, CGS 25462, and its metabolites (CGS 25659 and CGS 24592) in human plasma by high-performance liquid chromatography. JChromatogr B Biomed Sci Appl. 1998 Mar 20;706(2):287-94. DM2OWCV RU https://pubmed.ncbi.nlm.nih.gov/9551815 DM03XVA DI DM03XVA DM03XVA DN CI-1018 DM03XVA MI TTZ97H5 DM03XVA MN Phosphodiesterase 4A (PDE4A) DM03XVA MT DTT DM03XVA MA Inhibitor DM03XVA RN New substituted triaza-benzo[cd]azulen-9-ones as promising phosphodiesterase-4 inhibitors. Bioorg Med Chem Lett. 2004 Jun 21;14(12):3303-6. DM03XVA RU https://pubmed.ncbi.nlm.nih.gov/15149695 DM03XVA DI DM03XVA DM03XVA DN CI-1018 DM03XVA MI TTVIAT9 DM03XVA MN Phosphodiesterase 4B (PDE4B) DM03XVA MT DTT DM03XVA MA Inhibitor DM03XVA RN New substituted triaza-benzo[cd]azulen-9-ones as promising phosphodiesterase-4 inhibitors. Bioorg Med Chem Lett. 2004 Jun 21;14(12):3303-6. DM03XVA RU https://pubmed.ncbi.nlm.nih.gov/15149695 DM03XVA DI DM03XVA DM03XVA DN CI-1018 DM03XVA MI TTSKMI8 DM03XVA MN Phosphodiesterase 4D (PDE4D) DM03XVA MT DTT DM03XVA MA Inhibitor DM03XVA RN New substituted triaza-benzo[cd]azulen-9-ones as promising phosphodiesterase-4 inhibitors. Bioorg Med Chem Lett. 2004 Jun 21;14(12):3303-6. DM03XVA RU https://pubmed.ncbi.nlm.nih.gov/15149695 DMADPQX DI DMADPQX DMADPQX DN CI-930 DMADPQX MI TT06AWU DMADPQX MN Phosphodiesterase 3A (PDE3A) DMADPQX MT DTT DMADPQX MA Inhibitor DMADPQX RN Cardiotonic agents. 9. Synthesis and biological evaluation of a series of (E)-4,5-dihydro-6-[2-[4-(1H-imidazol-1-yl)phenyl]ethenyl]-3 (2H)-pyridazi... J Med Chem. 1989 Feb;32(2):342-50. DMADPQX RU https://pubmed.ncbi.nlm.nih.gov/2536438 DMN4QSW DI DMN4QSW DMN4QSW DN CI-949 DMN4QSW MI TTN53ZF DMN4QSW MN Leukotriene B4 receptor 1 (LTB4R) DMN4QSW MT DTT DMN4QSW MA Modulator DMN4QSW RN Inhibition of histamine, leukotriene C4/D4, and thromboxane B2 release from human leukocytes and human chopped lung mast cells by the allergic mediator release inhibitor, CI-949. J Allergy Clin Immunol. 1990 Dec;86(6 Pt 1):902-8. DMN4QSW RU https://pubmed.ncbi.nlm.nih.gov/1702129 DMBO28J DI DMBO28J DMBO28J DN CI-976 DMBO28J MI TTMF541 DMBO28J MN Liver carboxylesterase (CES1) DMBO28J MT DTT DMBO28J MA Inhibitor DMBO28J RN Acyl-coenzyme A:cholesterol-acyltransferase (ACAT) inhibitors modulate monocyte adhesion to aortic endothelial cells. Atherosclerosis. 1995 Jan 6;112(1):7-17. DMBO28J RU https://pubmed.ncbi.nlm.nih.gov/7772069 DMTAKNF DI DMTAKNF DMTAKNF DN Cipralisant DMTAKNF MI TT9JNIC DMTAKNF MN Histamine H3 receptor (H3R) DMTAKNF MT DTT DMTAKNF MA Binder DMTAKNF RN G protein-dependent pharmacology of histamine H3 receptor ligands: evidence for heterogeneous active state receptor conformations. J Pharmacol Exp Ther. 2005 Jul;314(1):271-81. DMTAKNF RU https://pubmed.ncbi.nlm.nih.gov/15821027 DM1CDNS DI DM1CDNS DM1CDNS DN CJ-13610 DM1CDNS MI TT2J34L DM1CDNS MN Arachidonate 5-lipoxygenase (5-LOX) DM1CDNS MT DTT DM1CDNS MA Inhibitor DM1CDNS RN Emerging drugs for the treatment of chronic obstructive pulmonary disease. Expert Opin Emerg Drugs. 2006 May;11(2):275-91. DM1CDNS RU https://pubmed.ncbi.nlm.nih.gov/16634702 DMQD2LS DI DMQD2LS DMQD2LS DN CJC-1131 DMQD2LS MI TTVIMDE DMQD2LS MN Glucagon-like peptide 1 receptor (GLP1R) DMQD2LS MT DTT DMQD2LS MA Modulator DMQD2LS RN Pharmacokinetics and tolerability of a novel long-acting glucagon-like peptide-1 analog, CJC-1131, in healthy and diabetic subjects. Int J Clin Pharmacol Ther. 2008 Sep;46(9):443-52. DMQD2LS RU https://pubmed.ncbi.nlm.nih.gov/18793574 DM7LIDT DI DM7LIDT DM7LIDT DN CL-283796 DM7LIDT MI TTMF541 DM7LIDT MN Liver carboxylesterase (CES1) DM7LIDT MT DTT DM7LIDT MA Modulator DM7LIDT RN ACAT inhibitors CL 283,546 and CL 283,796 reduce LDL cholesterol without affecting cholesterol absorption in African green monkeys. J Lipid Res. 1995 Jun;36(6):1199-210. DM7LIDT RU https://pubmed.ncbi.nlm.nih.gov/7665998 DMKFMYR DI DMKFMYR DMKFMYR DN CLOTURIN DMKFMYR MI TTUBNVO DMKFMYR MN DNA synthesis (DNA synth) DMKFMYR MT DTT DMKFMYR MA Modulator DMKFMYR RN Inhibition of biosynthetic processes in P388 and Ehrlich ascites cells by cloturin. Drugs Exp Clin Res. 1988;14(9):575-80. DMKFMYR RU https://pubmed.ncbi.nlm.nih.gov/3229320 DMRVJ1A DI DMRVJ1A DMRVJ1A DN Corus 1030 DMRVJ1A MI TT4G2JS DMRVJ1A MN Voltage-gated sodium channel alpha Nav1.7 (SCN9A) DMRVJ1A MT DTT DMRVJ1A MA Modulator DMRVJ1A RN Differential modulation of Nav1.7 and Nav1.8 peripheral nerve sodium channels by the local anesthetic lidocaine. Br J Pharmacol. 2004 Jun;142(3):576-84. DMRVJ1A RU https://pubmed.ncbi.nlm.nih.gov/15148257 DMRVJ1A DI DMRVJ1A DMRVJ1A DN Corus 1030 DMRVJ1A MI TT90XZ8 DMRVJ1A MN Voltage-gated sodium channel alpha Nav1.8 (SCN10A) DMRVJ1A MT DTT DMRVJ1A MA Modulator DMRVJ1A RN Differential modulation of Nav1.7 and Nav1.8 peripheral nerve sodium channels by the local anesthetic lidocaine. Br J Pharmacol. 2004 Jun;142(3):576-84. DMRVJ1A RU https://pubmed.ncbi.nlm.nih.gov/15148257 DMNJD9H DI DMNJD9H DMNJD9H DN CP-118 DMNJD9H MI TT7CXIM DMNJD9H MN Histamine receptor (HR) DMNJD9H MT DTT DMNJD9H MA Antagonist DMNJD9H RN Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800025139) DMNJD9H RU http://adisinsight.springer.com/drugs/800025139 DM3OJP0 DI DM3OJP0 DM3OJP0 DN CP-122288 DM3OJP0 MI TT6MSOK DM3OJP0 MN 5-HT 1D receptor (HTR1D) DM3OJP0 MT DTT DM3OJP0 MA Agonist DM3OJP0 RN The 5-HT1D receptor antagonist GR-127,935 prevents inhibitory effects of sumatriptan but not CP-122,288 and 5-CT on neurogenic plasma extravasation within guinea pig dura mater. Neuropharmacology. 1997 Jan;36(1):83-91. DM3OJP0 RU https://pubmed.ncbi.nlm.nih.gov/9144644 DM1OSUR DI DM1OSUR DM1OSUR DN CP-195543 DM1OSUR MI TTN53ZF DM1OSUR MN Leukotriene B4 receptor 1 (LTB4R) DM1OSUR MT DTT DM1OSUR MA Antagonist DM1OSUR RN The synthesis of CP-195543, an LTB4 antagonist for the treatment of inflammatory diseases. Curr Opin Drug Discov Devel. 1999 Nov;2(6):550-6. DM1OSUR RU https://pubmed.ncbi.nlm.nih.gov/19649826 DMZ76EM DI DMZ76EM DMZ76EM DN CP-316,311 DMZ76EM MI TT7EFHR DMZ76EM MN Corticotropin-releasing factor receptor 1 (CRHR1) DMZ76EM MT DTT DMZ76EM MA Antagonist DMZ76EM RN Novel drugs and therapeutic targets for severe mood disorders. Neuropsychopharmacology. 2008 Aug;33(9):2080-92. DMZ76EM RU https://pubmed.ncbi.nlm.nih.gov/18172433 DMH5LKS DI DMH5LKS DMH5LKS DN CPA-926 DMH5LKS MI TTG3K2U DMH5LKS MN Lipoxygenase (ALOX) DMH5LKS MT DTT DMH5LKS MA Modulator DMH5LKS RN Esculetin (dihydroxycoumarin) inhibits the production of matrix metalloproteinases in cartilage explants, and oral administration of its prodrug, CPA-926, suppresses cartilage destruction in rabbit experimental osteoarthritis. J Rheumatol. 1999 Mar;26(3):654-62. DMH5LKS RU https://pubmed.ncbi.nlm.nih.gov/10090178 DMVU4A5 DI DMVU4A5 DMVU4A5 DN CRD-5 DMVU4A5 MI TT7GN3U DMVU4A5 MN Apolipoprotein A-I (APOA1) DMVU4A5 MT DTT DMVU4A5 MA Stimulator DMVU4A5 RN Emerging antidyslipidemic drugs. Expert Opin Emerg Drugs. 2008 Jun;13(2):363-81. DMVU4A5 RU https://pubmed.ncbi.nlm.nih.gov/18537526 DMZLIUQ DI DMZLIUQ DMZLIUQ DN Cromafiban DMZLIUQ MI TT38RM1 DMZLIUQ MN Glycoprotein IIb/IIIa receptor (GPIIb/IIIa) DMZLIUQ MT DTT DMZLIUQ MA Modulator DMZLIUQ RN Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41. DMZLIUQ RU https://www.ncbi.nlm.nih.gov/pubmed/15950434 DMB9QSJ DI DMB9QSJ DMB9QSJ DN CRx-191 DMB9QSJ MI TT93WF5 DMB9QSJ MN Interferon-gamma (IFNG) DMB9QSJ MT DTT DMB9QSJ MA Inhibitor DMB9QSJ RN CombinatoRx Drug Candidate CRx-191 Demonstrates Positive Phase 2 Results In Psoriasis. CombinatoRx. 2008. DMB9QSJ RU http://www.medicalnewstoday.com/articles/100566.php DMB9QSJ DI DMB9QSJ DMB9QSJ DN CRx-191 DMB9QSJ MI TTF8CQI DMB9QSJ MN Tumor necrosis factor (TNF) DMB9QSJ MT DTT DMB9QSJ MA Inhibitor DMB9QSJ RN CombinatoRx Drug Candidate CRx-191 Demonstrates Positive Phase 2 Results In Psoriasis. CombinatoRx. 2008. DMB9QSJ RU http://www.medicalnewstoday.com/articles/100566.php DM39N7W DI DM39N7W DM39N7W DN CRx-401 DM39N7W MI TT8NGED DM39N7W MN Prostaglandin G/H synthase 1 (COX-1) DM39N7W MT DTT DM39N7W MA Inhibitor DM39N7W RN ClinicalTrials.gov (NCT00506298) Study of CRx-401 on Glucose Levels in Subjects With Type II Diabetes. U.S. National Institutes of Health. DM39N7W RU https://clinicaltrials.gov/ct2/show/NCT00506298 DM39N7W DI DM39N7W DM39N7W DN CRx-401 DM39N7W MI TTVKILB DM39N7W MN Prostaglandin G/H synthase 2 (COX-2) DM39N7W MT DTT DM39N7W MA Inhibitor DM39N7W RN ClinicalTrials.gov (NCT00506298) Study of CRx-401 on Glucose Levels in Subjects With Type II Diabetes. U.S. National Institutes of Health. DM39N7W RU https://clinicaltrials.gov/ct2/show/NCT00506298 DM73C4K DI DM73C4K DM73C4K DN Cryptophycin DM73C4K MI TTML2WA DM73C4K MN Tubulin (TUB) DM73C4K MT DTT DM73C4K MA Inducer DM73C4K RN Single-walled tubulin ring polymers. Biopolymers. 2007 Aug 5-15;86(5-6):424-36. DM73C4K RU https://pubmed.ncbi.nlm.nih.gov/17480000 DM1AEVT DI DM1AEVT DM1AEVT DN CS-003 DM1AEVT MI TTBPGLU DM1AEVT MN Neuromedin-K receptor (TACR3) DM1AEVT MT DTT DM1AEVT MA Antagonist DM1AEVT RN Emerging drugs for the treatment of chronic obstructive pulmonary disease. Expert Opin Emerg Drugs. 2006 May;11(2):275-91. DM1AEVT RU https://pubmed.ncbi.nlm.nih.gov/16634702 DM1AEVT DI DM1AEVT DM1AEVT DN CS-003 DM1AEVT MI TTYO0A3 DM1AEVT MN Substance-K receptor (TACR2) DM1AEVT MT DTT DM1AEVT MA Antagonist DM1AEVT RN Emerging drugs for the treatment of chronic obstructive pulmonary disease. Expert Opin Emerg Drugs. 2006 May;11(2):275-91. DM1AEVT RU https://pubmed.ncbi.nlm.nih.gov/16634702 DM1AEVT DI DM1AEVT DM1AEVT DN CS-003 DM1AEVT MI TTZPO1L DM1AEVT MN Substance-P receptor (TACR1) DM1AEVT MT DTT DM1AEVT MA Antagonist DM1AEVT RN Emerging drugs for the treatment of chronic obstructive pulmonary disease. Expert Opin Emerg Drugs. 2006 May;11(2):275-91. DM1AEVT RU https://pubmed.ncbi.nlm.nih.gov/16634702 DMGYXA4 DI DMGYXA4 DMGYXA4 DN CS-722 DMGYXA4 MI TT3WG5C DMGYXA4 MN Monoamine oxidase type A (MAO-A) DMGYXA4 MT DTT DMGYXA4 MA Inhibitor DMGYXA4 RN Mechanisms of spinal reflex depressant effects of CS-722, a newly synthesized centrally acting muscle relaxant, in spinal rats. Neuropharmacology. 1992 Sep;31(9):949-54. DMGYXA4 RU https://pubmed.ncbi.nlm.nih.gov/1436401 DM17I8O DI DM17I8O DM17I8O DN CS-891B DM17I8O MI TT2A0DR DM17I8O MN Oxo-5-alpha-steroid 4-dehydrogenase (SRD5A) DM17I8O MT DTT DM17I8O MA Inhibitor DM17I8O RN The novel drug CS-891 inhibits 5alpha-reductase activity in freshly isolated dermal papilla of human hair follicles. Eur J Dermatol. 2000 Dec;10(8):593-5. DM17I8O RU https://pubmed.ncbi.nlm.nih.gov/11125319 DM09CUO DI DM09CUO DM09CUO DN CTL-102-GDEPT DM09CUO MI TTFBNVI DM09CUO MN Aldose reductase (AKR1B1) DM09CUO MT DTT DM09CUO MA Modulator DM09CUO RN Genes in the Service of Therapeutic Index: Progress for Virus-Directed Enzyme Prodrug Therapy. JCO May 1, 2004 vol. 22 no. 9 1535-1537c. DM09CUO RU http://jco.ascopubs.org/content/22/9/1535.full DMG3HX2 DI DMG3HX2 DMG3HX2 DN CV-6504 DMG3HX2 MI TT2J34L DMG3HX2 MN Arachidonate 5-lipoxygenase (5-LOX) DMG3HX2 MT DTT DMG3HX2 MA Inhibitor DMG3HX2 RN A phase II study of the 5-lipoxygenase inhibitor, CV6504, in advanced pancreatic cancer: correlation of clinical data with pharmacokinetic and pharmacodynamic endpoints. Ann Oncol. 2000 Sep;11(9):1165-70. DMG3HX2 RU https://pubmed.ncbi.nlm.nih.gov/11061613 DMP8TKA DI DMP8TKA DMP8TKA DN CY-208243 DMP8TKA MI TTZFYLI DMP8TKA MN Dopamine D1 receptor (D1R) DMP8TKA MT DTT DMP8TKA MA Agonist DMP8TKA RN The D-1 dopamine receptor partial agonist, CY 208-243, exhibits antiparkinsonian activity in the MPTP-treated marmoset. Eur J Pharmacol. 1988 Nov 1;156(2):197-206. DMP8TKA RU https://pubmed.ncbi.nlm.nih.gov/2977118 DMP8TKA DI DMP8TKA DMP8TKA DN CY-208243 DMP8TKA MI TT0R12H DMP8TKA MN Neuron-specific vesicular protein calcyon (CALY) DMP8TKA MT DTT DMP8TKA MA Activator DMP8TKA RN Dopamine D1 receptor agonists induce penile erections in rats. Eur J Pharmacol. 2003 Jan 26;460(1):71-4. DMP8TKA RU https://pubmed.ncbi.nlm.nih.gov/12535862 DMO9HWU DI DMO9HWU DMO9HWU DN D-7193 DMO9HWU MI TTK0943 DMO9HWU MN Prostaglandin G/H synthase (COX) DMO9HWU MT DTT DMO9HWU MA Modulator DMO9HWU RN US patent application no. 6,673,908, Tumor necrosis factor receptor 2. DMO9HWU RU http://www.google.com/patents/US6673908 DM48ECA DI DM48ECA DM48ECA DN DA-5018 DM48ECA MI TTMI6F5 DM48ECA MN Transient receptor potential cation channel V1 (TRPV1) DM48ECA MT DTT DM48ECA MA Modulator DM48ECA RN Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41. DM48ECA RU https://www.ncbi.nlm.nih.gov/pubmed/15950434 DMDQH5E DI DMDQH5E DMDQH5E DN Dabuzalgron DMDQH5E MI TT34BHT DMDQH5E MN Adrenergic receptor alpha-1D (ADRA1D) DMDQH5E MT DTT DMDQH5E MA Agonist DMDQH5E RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 3469). DMDQH5E RU http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=3469 DMF3E51 DI DMF3E51 DMF3E51 DN DANOFLOXACIN DMF3E51 MI TTN6J5F DMF3E51 MN Bacterial DNA gyrase (Bact gyrase) DMF3E51 MT DTT DMF3E51 MA Modulator DMF3E51 RN Pharmacokinetics and penetration of danofloxacin from the blood into the milk of cows. J Vet Pharmacol Ther. 1998 Jun;21(3):209-13. DMF3E51 RU https://www.ncbi.nlm.nih.gov/pubmed/9673962 DMJ4WR6 DI DMJ4WR6 DMJ4WR6 DN Darotropium DMJ4WR6 MI TTZ9SOR DMJ4WR6 MN Muscarinic acetylcholine receptor M1 (CHRM1) DMJ4WR6 MT DTT DMJ4WR6 MA Agonist DMJ4WR6 RN Clinical pipeline report, company report or official report of GlaxoSmithKline (2009). DMJ4WR6 RU http://www.gsk.com/investors/product_pipeline/docs/gsk-pipeline-feb09.pdf DMOWIGC DI DMOWIGC DMOWIGC DN DASANTAFIL DMOWIGC MI TTJ0IQB DMOWIGC MN Phosphodiesterase 5A (PDE5A) DMOWIGC MT DTT DMOWIGC MA Inhibitor DMOWIGC RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015 DMOWIGC RU https://www.accessdata.fda.gov/scripts/cder/drugsatfda/ DMY3M0J DI DMY3M0J DMY3M0J DN DAT-582 DMY3M0J MI TTNXLKE DMY3M0J MN 5-HT 3 receptor (5HT3R) DMY3M0J MT DTT DMY3M0J MA Antagonist DMY3M0J RN 5-HT3 receptor antagonist effects of DAT-582, (R) enantiomer of AS-5370. Eur J Pharmacol. 1992 Jun 17;216(3):435-40. DMY3M0J RU https://pubmed.ncbi.nlm.nih.gov/1425931 DM9S3R8 DI DM9S3R8 DM9S3R8 DN Davalintide DM9S3R8 MI TTAT87F DM9S3R8 MN Amylin receptor (IAPPR) DM9S3R8 MT DTT DM9S3R8 MA Agonist DM9S3R8 RN Davalintide (AC2307), a novel amylin-mimetic peptide: enhanced pharmacological properties over native amylin to reduce food intake and body weight. Int J Obes (Lond). 2010 Feb;34(2):385-95. DM9S3R8 RU https://pubmed.ncbi.nlm.nih.gov/19935749 DMXO9BQ DI DMXO9BQ DMXO9BQ DN Daxalipram DMXO9BQ MI TTZ97H5 DMXO9BQ MN Phosphodiesterase 4A (PDE4A) DMXO9BQ MT DTT DMXO9BQ MA Inhibitor DMXO9BQ RN Inhibition of phosphodiesterase 4 reduces ethanol intake and preference in C57BL/6J mice. Front Neurosci. 2014 May 27;8:129. DMXO9BQ RU https://pubmed.ncbi.nlm.nih.gov/24904269 DMXO9BQ DI DMXO9BQ DMXO9BQ DN Daxalipram DMXO9BQ MI TTVIAT9 DMXO9BQ MN Phosphodiesterase 4B (PDE4B) DMXO9BQ MT DTT DMXO9BQ MA Inhibitor DMXO9BQ RN Inhibition of phosphodiesterase 4 reduces ethanol intake and preference in C57BL/6J mice. Front Neurosci. 2014 May 27;8:129. DMXO9BQ RU https://pubmed.ncbi.nlm.nih.gov/24904269 DMXO9BQ DI DMXO9BQ DMXO9BQ DN Daxalipram DMXO9BQ MI TTSKMI8 DMXO9BQ MN Phosphodiesterase 4D (PDE4D) DMXO9BQ MT DTT DMXO9BQ MA Inhibitor DMXO9BQ RN Inhibition of phosphodiesterase 4 reduces ethanol intake and preference in C57BL/6J mice. Front Neurosci. 2014 May 27;8:129. DMXO9BQ RU https://pubmed.ncbi.nlm.nih.gov/24904269 DMGM2HY DI DMGM2HY DMGM2HY DN DCDT-2980S DMGM2HY MI TTM6QSK DMGM2HY MN B-cell receptor CD22 (CD22) DMGM2HY MT DTT DMGM2HY RN Efficacy and toxicity of a CD22-targeted antibody-saporin conjugate in a xenograft model of non-Hodgkin's lymphoma. Oncoimmunology. 2012 December 1; 1(9): 1469-1475. DMGM2HY RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3525602/ DMMV6RK DI DMMV6RK DMMV6RK DN DDP-200 DMMV6RK MI TTH18TF DMMV6RK MN Muscarinic acetylcholine receptor M5 (CHRM5) DMMV6RK MT DTT DMMV6RK MA Modulator DMMV6RK RN CA patent application no. 753057, Sustained release oral dosage forms of an r-baclofen prodrug. DMMV6RK RU http://www.google.com/patents/CA2753057A1?cl=en DM3AVO1 DI DM3AVO1 DM3AVO1 DN DE-081 DM3AVO1 MI DTUGYRD DM3AVO1 MN P-glycoprotein 1 (ABCB1) DM3AVO1 MT DTP DM3AVO1 MA Substrate DM3AVO1 RN Altered drug disposition of the platelet activating factor antagonist apafant in mdr1a knockout mice. Eur J Pharm Sci. 2002 Aug;16(3):119-28. DM3AVO1 RU https://doi.org/10.1016/S0928-0987(02)00088-X DM3AVO1 DI DM3AVO1 DM3AVO1 DN DE-081 DM3AVO1 MI TTQL5VC DM3AVO1 MN Platelet-activating factor receptor (PTAFR) DM3AVO1 MT DTT DM3AVO1 MA Modulator DM3AVO1 RN Characterization of [3H]apafant binding to PAF receptor on rabbit platelet membranes: a comparison of a microplate filtration system and a standard... J Pharmacol Toxicol Methods. 1996 Sep;36(1):53-62. DM3AVO1 RU https://pubmed.ncbi.nlm.nih.gov/8872920 DM5QFT4 DI DM5QFT4 DM5QFT4 DN Declopramide DM5QFT4 MI TTEX248 DM5QFT4 MN Dopamine D2 receptor (D2R) DM5QFT4 MT DTT DM5QFT4 MA Modulator DM5QFT4 RN Pharmacokinetics and central nervous system toxicity of declopramide (3-chloroprocainamide) in rats and mice. Anticancer Drugs. 1999 Jan;10(1):79-88. DM5QFT4 RU https://pubmed.ncbi.nlm.nih.gov/10194550 DM5QFT4 DI DM5QFT4 DM5QFT4 DN Declopramide DM5QFT4 MI TTZ9SOR DM5QFT4 MN Muscarinic acetylcholine receptor M1 (CHRM1) DM5QFT4 MT DTT DM5QFT4 MA Modulator DM5QFT4 RN Pharmacokinetics and central nervous system toxicity of declopramide (3-chloroprocainamide) in rats and mice. Anticancer Drugs. 1999 Jan;10(1):79-88. DM5QFT4 RU https://pubmed.ncbi.nlm.nih.gov/10194550 DMYJ28R DI DMYJ28R DMYJ28R DN Deriglidole DMYJ28R MI TT34BHT DMYJ28R MN Adrenergic receptor alpha-1D (ADRA1D) DMYJ28R MT DTT DMYJ28R MA Modulator DMYJ28R RN Mechanisms of the hypoglycemic effects of the alpha2-adrenoceptor antagonists SL84.0418 and deriglidole. Life Sci. 1998;62(9):839-52. DMYJ28R RU https://pubmed.ncbi.nlm.nih.gov/9496702 DMYJ28R DI DMYJ28R DMYJ28R DN Deriglidole DMYJ28R MI TT2NUT5 DMYJ28R MN Adrenergic receptor alpha-2C (ADRA2C) DMYJ28R MT DTT DMYJ28R MA Modulator DMYJ28R RN Mechanisms of the hypoglycemic effects of the alpha2-adrenoceptor antagonists SL84.0418 and deriglidole. Life Sci. 1998;62(9):839-52. DMYJ28R RU https://pubmed.ncbi.nlm.nih.gov/9496702 DM6WSU2 DI DM6WSU2 DM6WSU2 DN Dermolastin DM6WSU2 MI TTQAJF1 DM6WSU2 MN Cathepsin G (CTSG) DM6WSU2 MT DTT DM6WSU2 MA Inhibitor DM6WSU2 RN Arriva-ProMetic recombinant alpha 1-antitrypsin (rAAT) moves into the clinic for dermatology applications. ProMetic Life Sciences. 2009. DM6WSU2 RU http://www.prnewswire.co.uk/news-releases/arriva-prometic-recombinant-alpha-1-antitrypsin-raat-moves-into-the-clinic-for-dermatology-applications-154329065.html DM6WSU2 DI DM6WSU2 DM6WSU2 DN Dermolastin DM6WSU2 MI TT2WR1T DM6WSU2 MN Cationic trypsinogen (PRSS1) DM6WSU2 MT DTT DM6WSU2 MA Inhibitor DM6WSU2 RN Arriva-ProMetic recombinant alpha 1-antitrypsin (rAAT) moves into the clinic for dermatology applications. ProMetic Life Sciences. 2009. DM6WSU2 RU http://www.prnewswire.co.uk/news-releases/arriva-prometic-recombinant-alpha-1-antitrypsin-raat-moves-into-the-clinic-for-dermatology-applications-154329065.html DM6WSU2 DI DM6WSU2 DM6WSU2 DN Dermolastin DM6WSU2 MI TT6L509 DM6WSU2 MN Coagulation factor IIa (F2) DM6WSU2 MT DTT DM6WSU2 MA Inhibitor DM6WSU2 RN Arriva-ProMetic recombinant alpha 1-antitrypsin (rAAT) moves into the clinic for dermatology applications. ProMetic Life Sciences. 2009. DM6WSU2 RU http://www.prnewswire.co.uk/news-releases/arriva-prometic-recombinant-alpha-1-antitrypsin-raat-moves-into-the-clinic-for-dermatology-applications-154329065.html DM6WSU2 DI DM6WSU2 DM6WSU2 DN Dermolastin DM6WSU2 MI TTPLTSQ DM6WSU2 MN Neutrophil elastase (NE) DM6WSU2 MT DTT DM6WSU2 MA Inhibitor DM6WSU2 RN Arriva-ProMetic recombinant alpha 1-antitrypsin (rAAT) moves into the clinic for dermatology applications. ProMetic Life Sciences. 2009. DM6WSU2 RU http://www.prnewswire.co.uk/news-releases/arriva-prometic-recombinant-alpha-1-antitrypsin-raat-moves-into-the-clinic-for-dermatology-applications-154329065.html DM6WSU2 DI DM6WSU2 DM6WSU2 DN Dermolastin DM6WSU2 MI TTJLNAW DM6WSU2 MN Tissue kallikrein (KLK2) DM6WSU2 MT DTT DM6WSU2 MA Inhibitor DM6WSU2 RN Arriva-ProMetic recombinant alpha 1-antitrypsin (rAAT) moves into the clinic for dermatology applications. ProMetic Life Sciences. 2009. DM6WSU2 RU http://www.prnewswire.co.uk/news-releases/arriva-prometic-recombinant-alpha-1-antitrypsin-raat-moves-into-the-clinic-for-dermatology-applications-154329065.html DMLZIT2 DI DMLZIT2 DMLZIT2 DN Dexniguldipine DMLZIT2 MI DE4LYSA DMLZIT2 MN Cytochrome P450 3A4 (CYP3A4) DMLZIT2 MT DME DMLZIT2 MA Metabolism DMLZIT2 RN Integrated analysis on the physicochemical properties of dihydropyridine calcium channel blockers in grapefruit juice interactions. Curr Pharm Biotechnol. 2012 Jul;13(9):1705-17. DMLZIT2 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=22039822 DMLZIT2 DI DMLZIT2 DMLZIT2 DN Dexniguldipine DMLZIT2 MI TTJUXV6 DMLZIT2 MN Multidrug resistance protein 3 (ABCB4) DMLZIT2 MT DTT DMLZIT2 MA Modulator DMLZIT2 RN Mechanism of action of dexniguldipine-HCl (B8509-035), a new potent modulator of multidrug resistance. Biochem Pharmacol. 1995 Mar 1;49(5):603-9. DMLZIT2 RU https://pubmed.ncbi.nlm.nih.gov/7887974 DMLZIT2 DI DMLZIT2 DMLZIT2 DN Dexniguldipine DMLZIT2 MI DTUGYRD DMLZIT2 MN P-glycoprotein 1 (ABCB1) DMLZIT2 MT DTP DMLZIT2 MA Substrate DMLZIT2 RN Fingerprint-based in silico models for the prediction of P-glycoprotein substrates and inhibitors. Bioorg Med Chem. 2012 Sep 15;20(18):5388-95. DMLZIT2 RU https://doi.org/10.1016/j.bmc.2012.03.045 DMLZIT2 DI DMLZIT2 DMLZIT2 DN Dexniguldipine DMLZIT2 MI DEX2KIA DMLZIT2 MN Steroid 17-alpha-monooxygenase (CYP17A1) DMLZIT2 MT DME DMLZIT2 MA Metabolism DMLZIT2 RN In vitro metabolism of dexamethasone (DEX) in human liver and kidney: the involvement of CYP3A4 and CYP17 (17,20 LYASE) and molecular modelling studies. Biochem Pharmacol. 1997 Sep 1;54(5):605-11. DMLZIT2 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=9337077 DMJT8Q0 DI DMJT8Q0 DMJT8Q0 DN Dezinamide DMJT8Q0 MI TTNJYV2 DMJT8Q0 MN Gamma-aminobutyric acid receptor (GAR) DMJT8Q0 MT DTT DMJT8Q0 MA Modulator DMJT8Q0 RN Clobazam, oxcarbazepine, tiagabine, topiramate, and other new antiepileptic drugs. Epilepsia. 1995;36 Suppl 2:S105-14. DMJT8Q0 RU https://pubmed.ncbi.nlm.nih.gov/8784219 DMVO9WM DI DMVO9WM DMVO9WM DN DG041 DMVO9WM MI TTPNGDE DMVO9WM MN Prostaglandin E2 receptor EP3 (PTGER3) DMVO9WM MT DTT DMVO9WM MA Antagonist DMVO9WM RN BAY x 1005 attenuates atherosclerosis in apoE/LDLR - double knockout mice. J Physiol Pharmacol. 2007 Sep;58(3):583-8. DMVO9WM RU https://pubmed.ncbi.nlm.nih.gov/17928652 DM3I0GS DI DM3I0GS DM3I0GS DN DG051 DM3I0GS MI TTXZEAJ DM3I0GS MN Leukotriene A-4 hydrolase (LTA4H) DM3I0GS MT DTT DM3I0GS MA Inhibitor DM3I0GS RN BAY x 1005 attenuates atherosclerosis in apoE/LDLR - double knockout mice. J Physiol Pharmacol. 2007 Sep;58(3):583-8. DM3I0GS RU https://pubmed.ncbi.nlm.nih.gov/17928652 DM64CAS DI DM64CAS DM64CAS DN Didox DM64CAS MI TTX09M4 DM64CAS MN Ribonucleotide reductase (RIR) DM64CAS MT DTT DM64CAS MA Inhibitor DM64CAS RN Didox (a novel ribonucleotide reductase inhibitor) overcomes Bcl-2 mediated radiation resistance in prostate cancer cell line PC-3. Cancer Biol Ther. 2002 Sep-Oct;1(5):539-45. DM64CAS RU https://pubmed.ncbi.nlm.nih.gov/12496485 DMIP3EC DI DMIP3EC DMIP3EC DN DM-83 DMIP3EC MI TTCBFJO DMIP3EC MN Insulin receptor (INSR) DMIP3EC MT DTT DMIP3EC MA Stimulator DMIP3EC RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1800). DMIP3EC RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1800 DMCNEOZ DI DMCNEOZ DMCNEOZ DN DMP-543 DMCNEOZ MI TTQ29KF DMCNEOZ MN Voltage-gated potassium channel Kv7 (KCNQ) DMCNEOZ MT DTT DMCNEOZ MA Modulator DMCNEOZ RN KV7 channels regulate muscle tone and nonadrenergic noncholinergic relaxation of the rat gastric fundus.Pharmacol Res.2011 Oct;64(4):397-409. DMCNEOZ RU https://www.ncbi.nlm.nih.gov/pubmed/21740972 DMI5XKC DI DMI5XKC DMI5XKC DN DMP-961 DMI5XKC MI TT84ETX DMI5XKC MN Human immunodeficiency virus Reverse transcriptase (HIV RT) DMI5XKC MT DTT DMI5XKC MA Inhibitor DMI5XKC RN Effect of drug substance particle size on the characteristics of granulation manufactured in a high-shear mixer. AAPS PharmSciTech. 2000 December; 1(4): 55-61. DMI5XKC RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2750457/ DM4ZO01 DI DM4ZO01 DM4ZO01 DN DNK-333 DM4ZO01 MI TTYO0A3 DM4ZO01 MN Substance-K receptor (TACR2) DM4ZO01 MT DTT DM4ZO01 MA Modulator DM4ZO01 RN Dual tachykinin NK1/NK2 antagonist DNK333 inhibits neurokinin A-induced bronchoconstriction in asthma patients. Eur Respir J. 2004 Jan;23(1):76-81. DM4ZO01 RU https://www.ncbi.nlm.nih.gov/pubmed/14738235 DM4ZO01 DI DM4ZO01 DM4ZO01 DN DNK-333 DM4ZO01 MI TTZPO1L DM4ZO01 MN Substance-P receptor (TACR1) DM4ZO01 MT DTT DM4ZO01 MA Modulator DM4ZO01 RN Dual tachykinin NK1/NK2 antagonist DNK333 inhibits neurokinin A-induced bronchoconstriction in asthma patients. Eur Respir J. 2004 Jan;23(1):76-81. DM4ZO01 RU https://www.ncbi.nlm.nih.gov/pubmed/14738235 DMMC6H7 DI DMMC6H7 DMMC6H7 DN Dopropidil DMMC6H7 MI TT5HONZ DMMC6H7 MN Calcium channel unspecific (CaC) DMMC6H7 MT DTT DMMC6H7 MA Modulator DMMC6H7 RN Effects of bepridil and CERM 4205 (ORG 30701) on the relation between cardiac cycle length and QT duration in healthy volunteers. Am J Cardiol. 1990 Sep 1;66(5):636-41. DMMC6H7 RU https://pubmed.ncbi.nlm.nih.gov/2203243 DMTE14H DI DMTE14H DMTE14H DN DOV-216303 DMTE14H MI TTVBI8W DMTE14H MN Dopamine transporter (DAT) DMTE14H MT DTT DMTE14H MA Inhibitor DMTE14H RN Novel drugs and therapeutic targets for severe mood disorders. Neuropsychopharmacology. 2008 Aug;33(9):2080-92. DMTE14H RU https://pubmed.ncbi.nlm.nih.gov/18172433 DMTE14H DI DMTE14H DMTE14H DN DOV-216303 DMTE14H MI TTAWNKZ DMTE14H MN Norepinephrine transporter (NET) DMTE14H MT DTT DMTE14H MA Inhibitor DMTE14H RN Novel drugs and therapeutic targets for severe mood disorders. Neuropsychopharmacology. 2008 Aug;33(9):2080-92. DMTE14H RU https://pubmed.ncbi.nlm.nih.gov/18172433 DMTE14H DI DMTE14H DMTE14H DN DOV-216303 DMTE14H MI TT3ROYC DMTE14H MN Serotonin transporter (SERT) DMTE14H MT DTT DMTE14H MA Inhibitor DMTE14H RN Novel drugs and therapeutic targets for severe mood disorders. Neuropsychopharmacology. 2008 Aug;33(9):2080-92. DMTE14H RU https://pubmed.ncbi.nlm.nih.gov/18172433 DMKGXT2 DI DMKGXT2 DMKGXT2 DN DPI-3290 DMKGXT2 MI TT27RFC DMKGXT2 MN Opioid receptor delta (OPRD1) DMKGXT2 MT DTT DMKGXT2 MA Agonist DMKGXT2 RN DPI-3290 [(+)-3-((alpha-R)-alpha-((2S,5R)-4-Allyl-2,5-dimethyl-1-piperazinyl)-3-hydroxybenzyl)-N-(3-fluorophenyl)-N-methylbenzamide]. II. A mixed opioid agonist with potent antinociceptive activity and limited effects on respiratory function. J Pharmacol Exp Ther. 2003 Dec;307(3):1227-33. DMKGXT2 RU https://pubmed.ncbi.nlm.nih.gov/14534367 DMKGXT2 DI DMKGXT2 DMKGXT2 DN DPI-3290 DMKGXT2 MI TTKWM86 DMKGXT2 MN Opioid receptor mu (MOP) DMKGXT2 MT DTT DMKGXT2 MA Agonist DMKGXT2 RN DPI-3290 [(+)-3-((alpha-R)-alpha-((2S,5R)-4-Allyl-2,5-dimethyl-1-piperazinyl)-3-hydroxybenzyl)-N-(3-fluorophenyl)-N-methylbenzamide]. II. A mixed opioid agonist with potent antinociceptive activity and limited effects on respiratory function. J Pharmacol Exp Ther. 2003 Dec;307(3):1227-33. DMKGXT2 RU https://pubmed.ncbi.nlm.nih.gov/14534367 DMCZ75T DI DMCZ75T DMCZ75T DN DRAFLAZINE DMCZ75T MI TT5BN70 DMCZ75T MN Nucleoside transporter (SLC) DMCZ75T MT DTT DMCZ75T MA Modulator DMCZ75T RN Studies of the nucleoside transporter inhibitor, draflazine, in the human myocardium. Br J Pharmacol. 1994 May;112(1):137-42. DMCZ75T RU https://pubmed.ncbi.nlm.nih.gov/8032635 DM9JPUD DI DM9JPUD DM9JPUD DN Droloxifene DM9JPUD MI TTZAYWL DM9JPUD MN Estrogen receptor (ESR) DM9JPUD MT DTT DM9JPUD MA Modulator DM9JPUD RN Droloxifene, a new antiestrogen: its role in metastatic breast cancer. Breast Cancer Res Treat. 1994;31(1):83-94. DM9JPUD RU https://pubmed.ncbi.nlm.nih.gov/7981460 DM9JPUD DI DM9JPUD DM9JPUD DN Droloxifene DM9JPUD MI DTUGYRD DM9JPUD MN P-glycoprotein 1 (ABCB1) DM9JPUD MT DTP DM9JPUD MA Substrate DM9JPUD RN Human intestinal transporter database: QSAR modeling and virtual profiling of drug uptake, efflux and interactions. Pharm Res. 2013 Apr;30(4):996-1007. DM9JPUD RU https://doi.org/10.1007/s11095-012-0935-x DM8GZWC DI DM8GZWC DM8GZWC DN DS-4574 DM8GZWC MI TTGKOY9 DM8GZWC MN Leukotriene CysLT1 receptor (CYSLTR1) DM8GZWC MT DTT DM8GZWC MA Modulator DM8GZWC RN Inhibitory effect of DS-4574, a mast cell stabilizer with peptidoleukotriene receptor antagonism, on gastric acid secretion in rats. Eur J Pharmacol. 1994 Apr 1;255(1-3):229-34. DM8GZWC RU https://pubmed.ncbi.nlm.nih.gov/8026547 DM8GZWC DI DM8GZWC DM8GZWC DN DS-4574 DM8GZWC MI TT0PZR5 DM8GZWC MN Leukotriene CysLT2 receptor (CYSLTR2) DM8GZWC MT DTT DM8GZWC MA Modulator DM8GZWC RN Inhibitory effect of DS-4574, a mast cell stabilizer with peptidoleukotriene receptor antagonism, on gastric acid secretion in rats. Eur J Pharmacol. 1994 Apr 1;255(1-3):229-34. DM8GZWC RU https://pubmed.ncbi.nlm.nih.gov/8026547 DM63UA9 DI DM63UA9 DM63UA9 DN DU 125530 DM63UA9 MI TTSQIFT DM63UA9 MN 5-HT 1A receptor (HTR1A) DM63UA9 MT DTT DM63UA9 MA Antagonist DM63UA9 RN 5-Hydroxytryptamine1A receptor occupancy by novel full antagonist 2-[4-[4-(7-chloro-2,3-dihydro-1,4-benzdioxyn-5-yl)-1-piperazinyl]butyl]-1,2-benzisothiazol-3-(2H)-one-1,1-dioxide: a[11C][O-methyl-3H]-N-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamide trihydrochloride (WAY-100635) positron emission tomography study in humans. J Pharmacol Exp Ther. 2002 Jun;301(3):1144-50. DM63UA9 RU https://pubmed.ncbi.nlm.nih.gov/12023549 DMQ9IO0 DI DMQ9IO0 DMQ9IO0 DN DuP-654 DMQ9IO0 MI TT2J34L DMQ9IO0 MN Arachidonate 5-lipoxygenase (5-LOX) DMQ9IO0 MT DTT DMQ9IO0 MA Inhibitor DMQ9IO0 RN The lipoxygenase inhibitor 2-phenylmethyl-1-naphthol (DuP 654) is a 12(S)-hydroxyeicosatetraenoic acid receptor antagonist in the human epidermal cell line SCL-II. Skin Pharmacol. 1993;6(2):148-51. DMQ9IO0 RU https://pubmed.ncbi.nlm.nih.gov/8394724 DMSTA5L DI DMSTA5L DMSTA5L DN DX-619 DMSTA5L MI TTN6J5F DMSTA5L MN Bacterial DNA gyrase (Bact gyrase) DMSTA5L MT DTT DMSTA5L MA Modulator DMSTA5L RN DX-619, a novel des-fluoro(6) quinolone manifesting low frequency of selection of resistant Staphylococcus aureus mutants: quinolone resistance beyond modification of type II topoisomerases. Antimicrob Agents Chemother. 2005 Dec;49(12):5051-7. DMSTA5L RU https://pubmed.ncbi.nlm.nih.gov/16304172 DMSTA5L DI DMSTA5L DMSTA5L DN DX-619 DMSTA5L MI TTIXTO3 DMSTA5L MN Staphylococcus Topoisomerase IV (Stap-coc parC) DMSTA5L MT DTT DMSTA5L MA Modulator DMSTA5L RN DX-619, a novel des-fluoro(6) quinolone manifesting low frequency of selection of resistant Staphylococcus aureus mutants: quinolone resistance beyond modification of type II topoisomerases. Antimicrob Agents Chemother. 2005 Dec;49(12):5051-7. DMSTA5L RU https://pubmed.ncbi.nlm.nih.gov/16304172 DMEQLC4 DI DMEQLC4 DMEQLC4 DN DX-9065 DMEQLC4 MI TTCIHJA DMEQLC4 MN Coagulation factor Xa (F10) DMEQLC4 MT DTT DMEQLC4 MA Inhibitor DMEQLC4 RN Semuloparin for the prevention of venous thromboembolic events in cancer patients. Drugs Today (Barc). 2012 Jul;48(7):451-7. DMEQLC4 RU https://pubmed.ncbi.nlm.nih.gov/22844656 DMIXUMZ DI DMIXUMZ DMIXUMZ DN DX-9065a DMIXUMZ MI TTCIHJA DMIXUMZ MN Coagulation factor Xa (F10) DMIXUMZ MT DTT DMIXUMZ MA Inhibitor DMIXUMZ RN DX-9065a inhibition of factor Xa and the prothrombinase complex: mechanism of inhibition and comparison with therapeutic heparins. Thromb Haemost. 2003 Jan;89(1):112-21. DMIXUMZ RU https://pubmed.ncbi.nlm.nih.gov/12540961 DMT2WVP DI DMT2WVP DMT2WVP DN Dynorphin A DMT2WVP MI DENZF0O DMT2WVP MN Cytosol aminopeptidase (LAP3) DMT2WVP MT DME DMT2WVP MA Metabolism DMT2WVP RN Human brain leucyl aminopeptidase: isolation, characterization and specificity against some neuropeptides. Neuropeptides. 1991 Jul;19(3):163-8. DMT2WVP RU https://www.ncbi.nlm.nih.gov/pubmed/?term=1680222 DMT2WVP DI DMT2WVP DMT2WVP DN Dynorphin A DMT2WVP MI TT27RFC DMT2WVP MN Opioid receptor delta (OPRD1) DMT2WVP MT DTT DMT2WVP MA Inhibitor DMT2WVP RN Design and synthesis of highly potent and selective cyclic dynorphin A analogs. 2. New analogs. J Med Chem. 1993 Mar 19;36(6):750-7. DMT2WVP RU https://pubmed.ncbi.nlm.nih.gov/8096246 DMT2WVP DI DMT2WVP DMT2WVP DN Dynorphin A DMT2WVP MI TTQW87Y DMT2WVP MN Opioid receptor kappa (OPRK1) DMT2WVP MT DTT DMT2WVP MA Inhibitor DMT2WVP RN Use of receptor chimeras to identify small molecules with high affinity for the dynorphin A binding domain of the kappa opioid receptor. Bioorg Med Chem Lett. 2008 Jun 15;18(12):3667-71. DMT2WVP RU https://pubmed.ncbi.nlm.nih.gov/18487043 DMT2WVP DI DMT2WVP DMT2WVP DN Dynorphin A DMT2WVP MI TTKWM86 DMT2WVP MN Opioid receptor mu (MOP) DMT2WVP MT DTT DMT2WVP MA Inhibitor DMT2WVP RN Use of receptor chimeras to identify small molecules with high affinity for the dynorphin A binding domain of the kappa opioid receptor. Bioorg Med Chem Lett. 2008 Jun 15;18(12):3667-71. DMT2WVP RU https://pubmed.ncbi.nlm.nih.gov/18487043 DMHEW40 DI DMHEW40 DMHEW40 DN E-2078 DMHEW40 MI TTQW87Y DMHEW40 MN Opioid receptor kappa (OPRK1) DMHEW40 MT DTT DMHEW40 MA Modulator DMHEW40 RN Systemic effects of E-2078, a stabilized dynorphin A(1-8) analog, in rhesus monkeys. Psychopharmacology (Berl). 1999 Apr;143(2):190-6. DMHEW40 RU https://pubmed.ncbi.nlm.nih.gov/10326782 DM35KZG DI DM35KZG DM35KZG DN E-3040 DM35KZG MI TT2J34L DM35KZG MN Arachidonate 5-lipoxygenase (5-LOX) DM35KZG MT DTT DM35KZG MA Inhibitor DM35KZG RN In vitro effects of E3040, a dual inhibitor of 5-lipoxygenase and thromboxane A(2) synthetase, on eicosanoid production. Eur J Pharmacol. 2001 Jun 22;422(1-3):209-16. DM35KZG RU https://pubmed.ncbi.nlm.nih.gov/11430933 DM35KZG DI DM35KZG DM35KZG DN E-3040 DM35KZG MI DTI7UX6 DM35KZG MN Breast cancer resistance protein (ABCG2) DM35KZG MT DTP DM35KZG MA Substrate DM35KZG RN Role of the breast cancer resistance protein (ABCG2) in drug transport. AAPS J. 2005 May 11;7(1):E118-33. DM35KZG RU https://doi.org/10.1208/aapsj070112 DMWF95G DI DMWF95G DMWF95G DN E-3620 DMWF95G MI TTNXLKE DMWF95G MN 5-HT 3 receptor (5HT3R) DMWF95G MT DTT DMWF95G MA Modulator DMWF95G RN Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41. DMWF95G RU https://www.ncbi.nlm.nih.gov/pubmed/15950434 DMWF95G DI DMWF95G DMWF95G DN E-3620 DMWF95G MI TT07C3Y DMWF95G MN 5-HT 4 receptor (HTR4) DMWF95G MT DTT DMWF95G MA Modulator DMWF95G RN Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41. DMWF95G RU https://www.ncbi.nlm.nih.gov/pubmed/15950434 DMWIA56 DI DMWIA56 DMWIA56 DN E-4021 DMWIA56 MI TTJ0IQB DMWIA56 MN Phosphodiesterase 5A (PDE5A) DMWIA56 MT DTT DMWIA56 MA Inhibitor DMWIA56 RN Potency and mechanism of action of E4021, a type 5 phosphodiesterase isozyme-selective inhibitor, on the photoreceptor phosphodiesterase depend on the state of activation of the enzyme. Mol Pharmacol. 1999 Mar;55(3):508-14. DMWIA56 RU https://pubmed.ncbi.nlm.nih.gov/10051534 DMU872N DI DMU872N DMU872N DN E-4031 DMU872N MI TT1VOHK DMU872N MN Potassium channel unspecific (KC) DMU872N MT DTT DMU872N MA Modulator DMU872N RN Comparison of the IKr blockers moxifloxacin, dofetilide and E-4031 in five screening models of pro-arrhythmia reveals lack of specificity of isolated cardiomyocytes.Br J Pharmacol.2012 Jan;165(2):467-78. DMU872N RU https://www.ncbi.nlm.nih.gov/pubmed/21718297 DM2G7IP DI DM2G7IP DM2G7IP DN E-4177 DM2G7IP MI TTGN1ZA DM2G7IP MN Angiotensin II receptor (AGTR) DM2G7IP MT DTT DM2G7IP MA Modulator DM2G7IP RN Prevention of renal damage by angiotensin II blockade, accompanied by increased renal hepatocyte growth factor in experimental hypertensive rats. Hypertension. 1999 Aug;34(2):279-84. DM2G7IP RU https://pubmed.ncbi.nlm.nih.gov/10454454 DM562BM DI DM562BM DM562BM DN E-5324 DM562BM MI TTMF541 DM562BM MN Liver carboxylesterase (CES1) DM562BM MT DTT DM562BM MA Modulator DM562BM RN Effect of the acyl-CoA:cholesterol acyltransferase inhibitor, E5324, on experimental atherosclerosis in rabbits. Atherosclerosis. 1994 Jun;107(2):187-201. DM562BM RU https://pubmed.ncbi.nlm.nih.gov/7980693 DMBFYWU DI DMBFYWU DMBFYWU DN E-5531 DMBFYWU MI TTVQJLY DMBFYWU MN Lipopolysaccharide-binding protein (LBP) DMBFYWU MT DTT DMBFYWU MA Modulator DMBFYWU RN The cellular Toll-like receptor 4 antagonist E5531 can act as an agonist in horse whole blood. Vet Immunol Immunopathol. 2007 Apr 15;116(3-4):182-9. DMBFYWU RU https://pubmed.ncbi.nlm.nih.gov/17320193 DM296V7 DI DM296V7 DM296V7 DN E-6080 DM296V7 MI TT2J34L DM296V7 MN Arachidonate 5-lipoxygenase (5-LOX) DM296V7 MT DTT DM296V7 MA Inhibitor DM296V7 RN Effects of the new 5-lipoxygenase inhibitor E6080 on leukotriene release in vitro. Int Arch Allergy Immunol. 1992;97(4):267-73. DM296V7 RU https://pubmed.ncbi.nlm.nih.gov/1375926 DMUW6QX DI DMUW6QX DMUW6QX DN E-6123 DMUW6QX MI TTQL5VC DMUW6QX MN Platelet-activating factor receptor (PTAFR) DMUW6QX MT DTT DMUW6QX MA Modulator DMUW6QX RN Inhibitory effects of a novel PAF antagonist E6123 on anaphylactic responses in passively and actively sensitized guinea pigs and passively sensiti... Prostaglandins. 1991 Dec;42(6):541-55. DMUW6QX RU https://www.ncbi.nlm.nih.gov/pubmed/1801063 DMC28Y4 DI DMC28Y4 DMC28Y4 DN EAA-090 DMC28Y4 MI TT9IK2Z DMC28Y4 MN N-methyl-D-aspartate receptor (NMDAR) DMC28Y4 MT DTT DMC28Y4 MA Antagonist DMC28Y4 RN Emerging drugs in neuropathic pain. Expert Opin Emerg Drugs. 2007 Mar;12(1):113-26. DMC28Y4 RU https://pubmed.ncbi.nlm.nih.gov/17355217 DMJ2ZFV DI DMJ2ZFV DMJ2ZFV DN EB-1053 DMJ2ZFV MI TTKOBY0 DMJ2ZFV MN Bone resorption factor (BRF) DMJ2ZFV MT DTT DMJ2ZFV MA Modulator DMJ2ZFV RN Disodium 1-hydroxy-3-(1-pyrrolidinyl)-propylidene-1,1-bisphosphonate (EB-1053) is a potent inhibitor of bone resorption in vitro and in vivo. J Bone Miner Res. 1992 Aug;7(8):981-6. DMJ2ZFV RU https://pubmed.ncbi.nlm.nih.gov/1442212 DMRPUEC DI DMRPUEC DMRPUEC DN EDONENTAN HYDRATE DMRPUEC MI TTKRD0G DMRPUEC MN Endothelin A receptor (EDNRA) DMRPUEC MT DTT DMRPUEC MA Antagonist DMRPUEC RN US patent application no. 9,062,094, Dipeptide-based prodrug linkers for aliphatic amine-containing drugs. DMRPUEC RU http://www.google.com/patents/US9062094 DMZXRF2 DI DMZXRF2 DMZXRF2 DN Eflucimibe DMZXRF2 MI TTMF541 DMZXRF2 MN Liver carboxylesterase (CES1) DMZXRF2 MT DTT DMZXRF2 MA Inhibitor DMZXRF2 RN Prospects for drug therapy for hyperlipoproteinaemia. Diabete Metab. 1995 Apr;21(2):139-46. DMZXRF2 RU https://pubmed.ncbi.nlm.nih.gov/7621974 DM7TM91 DI DM7TM91 DM7TM91 DN ELAROFIBAN DM7TM91 MI TT38RM1 DM7TM91 MN Glycoprotein IIb/IIIa receptor (GPIIb/IIIa) DM7TM91 MT DTT DM7TM91 MA Modulator DM7TM91 RN 1,2,4-triazolo[3,4-a]pyridine as a novel, constrained template for fibrinogen receptor (GPIIb/IIIa) antagonists. Bioorg Med Chem Lett. 2001 Oct 8;11(19):2619-22. DM7TM91 RU https://pubmed.ncbi.nlm.nih.gov/11551763 DM0B23J DI DM0B23J DM0B23J DN ELB-139 DM0B23J MI TTAN6JD DM0B23J MN Glutamate receptor AMPA (GRIA) DM0B23J MT DTT DM0B23J MA Modulator DM0B23J RN Glutamate- and GABA-based CNS therapeutics. Curr Opin Pharmacol. 2006 Feb;6(1):7-17. DM0B23J RU https://pubmed.ncbi.nlm.nih.gov/16377242 DMBCYRG DI DMBCYRG DMBCYRG DN ELINAFIDE MESILATE DMBCYRG MI TT0IHXV DMBCYRG MN DNA topoisomerase II (TOP2) DMBCYRG MT DTT DMBCYRG MA Inhibitor DMBCYRG RN Solution structure and dynamics of a complex between DNA and the antitumor bisnaphthalimide LU-79553: intercalated ring flipping on the millisecond time scale. Biochemistry. 1999 Nov 16;38(46):15104-15. DMBCYRG RU https://pubmed.ncbi.nlm.nih.gov/10563793 DM0XF8J DI DM0XF8J DM0XF8J DN Elisartan potassium DM0XF8J MI TTGN1ZA DM0XF8J MN Angiotensin II receptor (AGTR) DM0XF8J MT DTT DM0XF8J MA Modulator DM0XF8J RN Safety and tolerability of losartan potassium, an angiotensin II receptor antagonist, compared with hydrochlorothiazide, atenolol, felodipine ER, and angiotensin-converting enzyme inhibitors for the treatment of systemic hypertension. Am J Cardiol. 1995 Apr 15;75(12):793-5. DM0XF8J RU https://pubmed.ncbi.nlm.nih.gov/7717281 DMM5WQL DI DMM5WQL DMM5WQL DN Elvucitabine DMM5WQL MI TT84ETX DMM5WQL MN Human immunodeficiency virus Reverse transcriptase (HIV RT) DMM5WQL MT DTT DMM5WQL MA Modulator DMM5WQL RN Multiple-dose pharmacokinetic behavior of elvucitabine, a nucleoside reverse transcriptase inhibitor, administered over 21 days with lopinavir-ritonavir in human immunodeficiency virus type 1-infected subjects.Antimicrob Agents Chemother.2009 Feb;53(2):662-9. DMM5WQL RU https://www.ncbi.nlm.nih.gov/pubmed/19015343 DM1EOC3 DI DM1EOC3 DM1EOC3 DN Elzasonan hydrochloride DM1EOC3 MI TTK8CXU DM1EOC3 MN 5-HT 1B receptor (HTR1B) DM1EOC3 MT DTT DM1EOC3 MA Modulator DM1EOC3 RN DOI: 10.1002/9781118541203.xen439 DM1EOC3 RU http://onlinelibrary.wiley.com/doi/10.1002/9781118541203.xen439/abstract DM1EOC3 DI DM1EOC3 DM1EOC3 DN Elzasonan hydrochloride DM1EOC3 MI TT6MSOK DM1EOC3 MN 5-HT 1D receptor (HTR1D) DM1EOC3 MT DTT DM1EOC3 MA Modulator DM1EOC3 RN DOI: 10.1002/9781118541203.xen439 DM1EOC3 RU http://onlinelibrary.wiley.com/doi/10.1002/9781118541203.xen439/abstract DM0RXCK DI DM0RXCK DM0RXCK DN Emapunil DM0RXCK MI TTPTXIN DM0RXCK MN Translocator protein (TSPO) DM0RXCK MT DTT DM0RXCK MA Agonist DM0RXCK RN Novel drugs and therapeutic targets for severe mood disorders. Neuropsychopharmacology. 2008 Aug;33(9):2080-92. DM0RXCK RU https://pubmed.ncbi.nlm.nih.gov/18172433 DMML2PX DI DMML2PX DMML2PX DN EML-336 DMML2PX MI TTCBFJO DMML2PX MN Insulin receptor (INSR) DMML2PX MT DTT DMML2PX MA Modulator DMML2PX RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1800). DMML2PX RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1800 DMIQRJW DI DMIQRJW DMIQRJW DN EMR-62203 DMIQRJW MI TTJ0IQB DMIQRJW MN Phosphodiesterase 5A (PDE5A) DMIQRJW MT DTT DMIQRJW MA Inhibitor DMIQRJW RN WO patent application no. 2006,0180,88, Use of a pde 5 inhibitor for treating and preventing hypopigmentary disorders. DMIQRJW RU http://worldwide.espacenet.com/publicationDetails/biblio?DB=worldwide.espacenet.com&II=0&ND=3&adjacent=true&locale=en_EP&FT=D&date=20060223&CC=WO&NR=2006018088A1&KC=A1 DMDAS5B DI DMDAS5B DMDAS5B DN Enalkiren DMDAS5B MI TTB2MXP DMDAS5B MN Angiotensinogenase renin (REN) DMDAS5B MT DTT DMDAS5B MA Inhibitor DMDAS5B RN Comparative effects of three different potent renin inhibitors in primates. Hypertension. 1993 Jul;22(1):9-17. DMDAS5B RU https://pubmed.ncbi.nlm.nih.gov/8319997 DME7OCX DI DME7OCX DME7OCX DN ENIPORIDE DME7OCX MI TTGSEFH DME7OCX MN Sodium/hydrogen exchanger 1 (SLC9A1) DME7OCX MT DTT DME7OCX MA Inhibitor DME7OCX RN Bicyclic acylguanidine Na+/H+ antiporter inhibitors. J Med Chem. 1998 Sep 10;41(19):3736-47. DME7OCX RU https://pubmed.ncbi.nlm.nih.gov/9733499 DME7OCX DI DME7OCX DME7OCX DN ENIPORIDE DME7OCX MI TTFZVPO DME7OCX MN Sodium/hydrogen exchanger 3 (SLC9A3) DME7OCX MT DTT DME7OCX MA Inhibitor DME7OCX RN Bicyclic acylguanidine Na+/H+ antiporter inhibitors. J Med Chem. 1998 Sep 10;41(19):3736-47. DME7OCX RU https://pubmed.ncbi.nlm.nih.gov/9733499 DM05F1Z DI DM05F1Z DM05F1Z DN ENRASENTAN DM05F1Z MI TTKRD0G DM05F1Z MN Endothelin A receptor (EDNRA) DM05F1Z MT DTT DM05F1Z MA Modulator DM05F1Z RN Enrasentan, an antagonist of endothelin receptors. Cardiovasc Drug Rev. 2003 Spring;21(1):1-16. DM05F1Z RU https://pubmed.ncbi.nlm.nih.gov/12595914 DM05F1Z DI DM05F1Z DM05F1Z DN ENRASENTAN DM05F1Z MI TT3ZTGU DM05F1Z MN Endothelin B receptor (EDNRB) DM05F1Z MT DTT DM05F1Z MA Modulator DM05F1Z RN Enrasentan, an antagonist of endothelin receptors. Cardiovasc Drug Rev. 2003 Spring;21(1):1-16. DM05F1Z RU https://pubmed.ncbi.nlm.nih.gov/12595914 DMG3R14 DI DMG3R14 DMG3R14 DN EP-2104R DMG3R14 MI TTWODQF DMG3R14 MN Fibrin (FG) DMG3R14 MT DTT DMG3R14 MA Modulator DMG3R14 RN EP-2104R: a fibrin-specific gadolinium-Based MRI contrast agent for detection of thrombus. J Am Chem Soc. 2008 May 7;130(18):6025-39. DMG3R14 RU https://pubmed.ncbi.nlm.nih.gov/18393503 DMZKBU9 DI DMZKBU9 DMZKBU9 DN EPC-K1 DMZKBU9 MI TT9V5JH DMZKBU9 MN Phospholipase A2 (PLA2G1B) DMZKBU9 MT DTT DMZKBU9 MA Inhibitor DMZKBU9 RN Posttreatment with EPC-K1, an inhibitor of lipid peroxidation and of phospholipase A2 activity, reduces functional deficits after global ischemia in rats. Brain Res Bull. 1995;36(3):257-60. DMZKBU9 RU https://pubmed.ncbi.nlm.nih.gov/7697379 DMJ52FZ DI DMJ52FZ DMJ52FZ DN EPI-2010 DMJ52FZ MI TT92EIB DMJ52FZ MN ADORA1 messenger RNA (ADORA1 mRNA) DMJ52FZ MT DTT DMJ52FZ RN RASONs: a novel antisense oligonucleotide therapeutic approach for asthma. Expert Opin Biol Ther. 2001 Nov;1(6):979-83. DMJ52FZ RU https://pubmed.ncbi.nlm.nih.gov/11728229 DM1WGUT DI DM1WGUT DM1WGUT DN Epothilone D DM1WGUT MI TTYFKSZ DM1WGUT MN Tubulin beta (TUBB) DM1WGUT MT DTT DM1WGUT MA Inhibitor DM1WGUT RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DM1WGUT RU https://pubmed.ncbi.nlm.nih.gov/17139284 DM6NTAS DI DM6NTAS DM6NTAS DN ERA-923 DM6NTAS MI TTZAYWL DM6NTAS MN Estrogen receptor (ESR) DM6NTAS MT DTT DM6NTAS MA Inhibitor DM6NTAS RN Combination therapy for treating breast cancer using antiestrogen, ERA-923, and the mammalian target of rapamycin inhibitor, temsirolimus. Endocr Relat Cancer. 2006 Sep;13(3):863-73. DM6NTAS RU https://pubmed.ncbi.nlm.nih.gov/16954435 DM6NTAS DI DM6NTAS DM6NTAS DN ERA-923 DM6NTAS MI TTOM3J0 DM6NTAS MN Estrogen receptor beta (ESR2) DM6NTAS MT DTT DM6NTAS MA Inhibitor DM6NTAS RN Design, synthesis, and preclinical characterization of novel, highly selective indole estrogens. J Med Chem. 2001 May 24;44(11):1654-7. DM6NTAS RU https://pubmed.ncbi.nlm.nih.gov/11356100 DM03I7V DI DM03I7V DM03I7V DN ERBULOZOLE DM03I7V MI TTML2WA DM03I7V MN Tubulin (TUB) DM03I7V MT DTT DM03I7V MA Modulator DM03I7V RN Influence of the synthetic microtubule inhibitor erbulozole (P.I.N.N.) (R 55 104), a new tubulozole congener, and gamma irradiation on murine tumors in vivo. Eur J Cancer Clin Oncol. 1989 Oct;25(10):1499-504. DM03I7V RU https://pubmed.ncbi.nlm.nih.gov/2591442 DMYR5OX DI DMYR5OX DMYR5OX DN EREMOMYCIN DMYR5OX MI TTXT4D5 DMYR5OX MN Bacterial Cell membrane (Bact CM) DMYR5OX MT DTT DMYR5OX MA Modulator DMYR5OX RN Role of the glycopeptide framework in the antibacterial activity of hydrophobic derivatives of glycopeptide antibiotics. J Med Chem. 2003 Mar 27;46(7):1204-9. DMYR5OX RU https://pubmed.ncbi.nlm.nih.gov/12646030 DMTUHWM DI DMTUHWM DMTUHWM DN Esreboxetine DMTUHWM MI TTAWNKZ DMTUHWM MN Norepinephrine transporter (NET) DMTUHWM MT DTT DMTUHWM MA Blocker DMTUHWM RN Pfizer. Product Development Pipeline. March 31 2009. DMTUHWM RU http://media.pfizer.com/files/research/pipeline/2009_0331/pipeline_2009_0331.pdf DM1DHOT DI DM1DHOT DM1DHOT DN Esuprone DM1DHOT MI TT3WG5C DM1DHOT MN Monoamine oxidase type A (MAO-A) DM1DHOT MT DTT DM1DHOT MA Inhibitor DM1DHOT RN MAO-A inhibition in brain after dosing with esuprone, moclobemide and placebo in healthy volunteers: in vivo studies with positron emission tomography. Eur J Clin Pharmacol. 1997;52(2):121-8. DM1DHOT RU https://pubmed.ncbi.nlm.nih.gov/9174681 DMEGMA2 DI DMEGMA2 DMEGMA2 DN ETH615 DMEGMA2 MI TT2J34L DMEGMA2 MN Arachidonate 5-lipoxygenase (5-LOX) DMEGMA2 MT DTT DMEGMA2 MA Inhibitor DMEGMA2 RN Preview of potential therapeutic applications of leukotriene B4 inhibitors in dermatology. Skin Pharmacol Appl Skin Physiol. 2000 Sep-Oct;13(5):235-45. DMEGMA2 RU https://pubmed.ncbi.nlm.nih.gov/10940813 DMRB23N DI DMRB23N DMRB23N DN ETRX-101 DMRB23N MI TTGN1ZA DMRB23N MN Angiotensin II receptor (AGTR) DMRB23N MT DTT DMRB23N MA Modulator DMRB23N RN WO patent application no. 2010,0332,07, Polymer conjugates of therapeutic peptides. DMRB23N RU http://worldwide.espacenet.com/publicationDetails/biblio?DB=worldwide.espacenet.com&II=0&ND=3&adjacent=true&locale=en_EP&FT=D&date=20100325&CC=WO&NR=2010033207A1&KC=A1 DMOYMGV DI DMOYMGV DMOYMGV DN EVT-101 DMOYMGV MI TTN9D8E DMOYMGV MN Glutamate receptor ionotropic NMDA 2B (NMDAR2B) DMOYMGV MT DTT DMOYMGV MA Antagonist DMOYMGV RN Glutamate- and GABA-based CNS therapeutics. Curr Opin Pharmacol. 2006 Feb;6(1):7-17. DMOYMGV RU https://pubmed.ncbi.nlm.nih.gov/16377242 DMGJMQH DI DMGJMQH DMGJMQH DN Examorelin DMGJMQH MI TTG4R8V DMGJMQH MN Growth hormone-releasing hormone receptor (GHRHR) DMGJMQH MT DTT DMGJMQH MA Modulator DMGJMQH RN Hexarelin is a stronger GH-releasing peptide than GHRH in normal cycling women but not in anorexia nervosa. J Endocrinol Invest. 1997 May;20(5):257-63. DMGJMQH RU https://pubmed.ncbi.nlm.nih.gov/9258804 DMTUPZ2 DI DMTUPZ2 DMTUPZ2 DN Ezlopitant DMTUPZ2 MI DECB0K3 DMTUPZ2 MN Cytochrome P450 2D6 (CYP2D6) DMTUPZ2 MT DME DMTUPZ2 MA Metabolism DMTUPZ2 RN Metabolism of ezlopitant, a nonpeptidic substance P receptor antagonist, in liver microsomes: enzyme kinetics, cytochrome P450 isoform identity, and in vitro-in vivo correlation. Drug Metab Dispos. 2000 Sep;28(9):1069-76. DMTUPZ2 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=10950851 DMTUPZ2 DI DMTUPZ2 DMTUPZ2 DN Ezlopitant DMTUPZ2 MI DE4LYSA DMTUPZ2 MN Cytochrome P450 3A4 (CYP3A4) DMTUPZ2 MT DME DMTUPZ2 MA Metabolism DMTUPZ2 RN Metabolism of ezlopitant, a nonpeptidic substance P receptor antagonist, in liver microsomes: enzyme kinetics, cytochrome P450 isoform identity, and in vitro-in vivo correlation. Drug Metab Dispos. 2000 Sep;28(9):1069-76. DMTUPZ2 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=10950851 DMTUPZ2 DI DMTUPZ2 DMTUPZ2 DN Ezlopitant DMTUPZ2 MI DEIBDNY DMTUPZ2 MN Cytochrome P450 3A5 (CYP3A5) DMTUPZ2 MT DME DMTUPZ2 MA Metabolism DMTUPZ2 RN Metabolism of ezlopitant, a nonpeptidic substance P receptor antagonist, in liver microsomes: enzyme kinetics, cytochrome P450 isoform identity, and in vitro-in vivo correlation. Drug Metab Dispos. 2000 Sep;28(9):1069-76. DMTUPZ2 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=10950851 DMTUPZ2 DI DMTUPZ2 DMTUPZ2 DN Ezlopitant DMTUPZ2 MI TTZPO1L DMTUPZ2 MN Substance-P receptor (TACR1) DMTUPZ2 MT DTT DMTUPZ2 MA Antagonist DMTUPZ2 RN Emerging drugs for chemotherapy-induced emesis. Expert Opin Emerg Drugs. 2006 Mar;11(1):137-51. DMTUPZ2 RU https://pubmed.ncbi.nlm.nih.gov/16503832 DMMSFK0 DI DMMSFK0 DMMSFK0 DN Fabesetron DMMSFK0 MI TTNXLKE DMMSFK0 MN 5-HT 3 receptor (5HT3R) DMMSFK0 MT DTT DMMSFK0 MA Modulator DMMSFK0 RN Pharmacological characterization of FK1052, a dihydropyridoindole derivative, as a new serotonin 3 and 4 dual receptor antagonist. J Pharmacol Exp Ther. 1993 May;265(2):752-8. DMMSFK0 RU https://www.ncbi.nlm.nih.gov/pubmed/8496821 DMMSFK0 DI DMMSFK0 DMMSFK0 DN Fabesetron DMMSFK0 MI TT07C3Y DMMSFK0 MN 5-HT 4 receptor (HTR4) DMMSFK0 MT DTT DMMSFK0 MA Modulator DMMSFK0 RN Pharmacological characterization of FK1052, a dihydropyridoindole derivative, as a new serotonin 3 and 4 dual receptor antagonist. J Pharmacol Exp Ther. 1993 May;265(2):752-8. DMMSFK0 RU https://www.ncbi.nlm.nih.gov/pubmed/8496821 DM8UC0K DI DM8UC0K DM8UC0K DN FANDOFLOXACIN HYDROCHLORIDE DM8UC0K MI TTN6J5F DM8UC0K MN Bacterial DNA gyrase (Bact gyrase) DM8UC0K MT DTT DM8UC0K MA Modulator DM8UC0K RN Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41. DM8UC0K RU https://www.ncbi.nlm.nih.gov/pubmed/15950434 DMRU1KT DI DMRU1KT DMRU1KT DN Fasidotril DMRU1KT MI TT5TKPM DMRU1KT MN Neutral endopeptidase (MME) DMRU1KT MT DTT DMRU1KT MA Modulator DMRU1KT RN Antihypertensive effects of fasidotril, a dual inhibitor of neprilysin and angiotensin-converting enzyme, in rats and humans. Hypertension. 2000 May;35(5):1148-53. DMRU1KT RU https://www.ncbi.nlm.nih.gov/pubmed/10818079 DMT2Z1L DI DMT2Z1L DMT2Z1L DN FCE-22716 DMT2Z1L MI TTJQOD7 DMT2Z1L MN 5-HT 2A receptor (HTR2A) DMT2Z1L MT DTT DMT2Z1L MA Antagonist DMT2Z1L RN Mechanism of the antihypertensive effect of FCE 22716, a new ergoline derivative, in the spontaneously hypertensive rat. Pharmacology. 1989;38(2):78-92. DMT2Z1L RU https://pubmed.ncbi.nlm.nih.gov/2727050 DMT2Z1L DI DMT2Z1L DMT2Z1L DN FCE-22716 DMT2Z1L MI TT34BHT DMT2Z1L MN Adrenergic receptor alpha-1D (ADRA1D) DMT2Z1L MT DTT DMT2Z1L MA Modulator DMT2Z1L RN Mechanism of the antihypertensive effect of FCE 22716, a new ergoline derivative, in the spontaneously hypertensive rat. Pharmacology. 1989;38(2):78-92. DMT2Z1L RU https://pubmed.ncbi.nlm.nih.gov/2727050 DMTQLIJ DI DMTQLIJ DMTQLIJ DN FCP-3P1 DMTQLIJ MI DEPKLMQ DMTQLIJ MN Cytochrome P450 2B6 (CYP2B6) DMTQLIJ MT DME DMTQLIJ MA Metabolism DMTQLIJ RN Conformational adaptation of human cytochrome P450 2B6 and rabbit cytochrome P450 2B4 revealed upon binding multiple amlodipine molecules. Biochemistry. 2012 Sep 18;51(37):7225-38. DMTQLIJ RU https://www.ncbi.nlm.nih.gov/pubmed/?term=22909231 DMTQLIJ DI DMTQLIJ DMTQLIJ DN FCP-3P1 DMTQLIJ MI DE4LYSA DMTQLIJ MN Cytochrome P450 3A4 (CYP3A4) DMTQLIJ MT DME DMTQLIJ MA Metabolism DMTQLIJ RN Amlodipine metabolism in human liver microsomes and roles of CYP3A4/5 in the dihydropyridine dehydrogenation. Drug Metab Dispos. 2014 Feb;42(2):245-9. DMTQLIJ RU https://www.ncbi.nlm.nih.gov/pubmed/?term=24301608 DMTQLIJ DI DMTQLIJ DMTQLIJ DN FCP-3P1 DMTQLIJ MI DEIBDNY DMTQLIJ MN Cytochrome P450 3A5 (CYP3A5) DMTQLIJ MT DME DMTQLIJ MA Metabolism DMTQLIJ RN Construction and verification of CYP3A5 gene polymorphisms using a Saccharomyces cerevisiae expression system to predict drug metabolism. Mol Med Rep. 2017 Apr;15(4):1593-1600. DMTQLIJ RU https://www.ncbi.nlm.nih.gov/pubmed/?term=28259948 DMJRF5G DI DMJRF5G DMJRF5G DN FIDUXOSIN HYDROCHLORIDE DMJRF5G MI TT34BHT DMJRF5G MN Adrenergic receptor alpha-1D (ADRA1D) DMJRF5G MT DTT DMJRF5G MA Antagonist DMJRF5G RN Effect of fiduxosin, an antagonist selective for alpha(1A)- and alpha(1D)-adrenoceptors, on intraurethral and arterial pressure responses in conscious dogs. J Pharmacol Exp Ther. 2002 Feb;300(2):487-94. DMJRF5G RU https://pubmed.ncbi.nlm.nih.gov/11805208 DMGD5QN DI DMGD5QN DMGD5QN DN Filaminast DMGD5QN MI TTVIAT9 DMGD5QN MN Phosphodiesterase 4B (PDE4B) DMGD5QN MT DTT DMGD5QN MA Inhibitor DMGD5QN RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMGD5QN RU https://pubmed.ncbi.nlm.nih.gov/17139284 DM06SC9 DI DM06SC9 DM06SC9 DN FINROZOLE DM06SC9 MI TTSZLWK DM06SC9 MN Aromatase (CYP19A1) DM06SC9 MT DTT DM06SC9 MA Inhibitor DM06SC9 RN Pharmacokinetics of finrozole (MPV-2213ad), a novel selective aromatase inhibitor, in healthy men. Br J Clin Pharmacol. 2001 Dec;52(6):702-4. DM06SC9 RU https://pubmed.ncbi.nlm.nih.gov/11736883 DMCINOE DI DMCINOE DMCINOE DN FK-011 DMCINOE MI TTGKOY9 DMCINOE MN Leukotriene CysLT1 receptor (CYSLTR1) DMCINOE MT DTT DMCINOE MA Modulator DMCINOE RN Evaluation of human peroxisome proliferator-activated receptor (PPAR) subtype selectivity of a variety of anti-inflammatory drugs based on a novel assay for PPAR delta(beta). J Pharmacol Sci. 2003 Nov;93(3):347-55. DMCINOE RU https://pubmed.ncbi.nlm.nih.gov/14646253 DM1JUS0 DI DM1JUS0 DM1JUS0 DN FK-224 DM1JUS0 MI TTYO0A3 DM1JUS0 MN Substance-K receptor (TACR2) DM1JUS0 MT DTT DM1JUS0 MA Modulator DM1JUS0 RN Effects of FK224, a novel compound NK1 and NK2 receptor antagonist, on airway constriction and airway edema induced by neurokinins and sensory nerv... J Pharmacol Exp Ther. 1992 Jul;262(1):403-8. DM1JUS0 RU https://www.ncbi.nlm.nih.gov/pubmed/1378097 DM1JUS0 DI DM1JUS0 DM1JUS0 DN FK-224 DM1JUS0 MI TTZPO1L DM1JUS0 MN Substance-P receptor (TACR1) DM1JUS0 MT DTT DM1JUS0 MA Modulator DM1JUS0 RN Effects of FK224, a novel compound NK1 and NK2 receptor antagonist, on airway constriction and airway edema induced by neurokinins and sensory nerv... J Pharmacol Exp Ther. 1992 Jul;262(1):403-8. DM1JUS0 RU https://www.ncbi.nlm.nih.gov/pubmed/1378097 DMHIUGT DI DMHIUGT DMHIUGT DN FK-352 DMHIUGT MI TTK25J1 DMHIUGT MN Adenosine A1 receptor (ADORA1) DMHIUGT MT DTT DMHIUGT MA Antagonist DMHIUGT RN Adenosine A1 receptor antagonist improves intradialytic hypotension. Kidney Int. 2006 Mar;69(5):877-83. DMHIUGT RU https://pubmed.ncbi.nlm.nih.gov/16395260 DMH3DXY DI DMH3DXY DMH3DXY DN FK-453 DMH3DXY MI TTK25J1 DMH3DXY MN Adenosine A1 receptor (ADORA1) DMH3DXY MT DTT DMH3DXY MA Modulator DMH3DXY RN Cardiovascular and renal effects of blocking A1 adenosine receptors. J Cardiovasc Pharmacol. 1993 May;21(5):822-8. DMH3DXY RU https://www.ncbi.nlm.nih.gov/pubmed/7685455 DMR2FPO DI DMR2FPO DMR2FPO DN FK-584 DMR2FPO MI TTH18TF DMR2FPO MN Muscarinic acetylcholine receptor M5 (CHRM5) DMR2FPO MT DTT DMR2FPO MA Modulator DMR2FPO RN US patent application no. 2005,0261,328, Pharmaceutical composition comprising beta-3-adrenoceptor-agonists and antimuscarinic agents. DMR2FPO RU http://www.google.com/patents/US20050261328 DMQ3O4C DI DMQ3O4C DMQ3O4C DN FK-633 DMQ3O4C MI TT38RM1 DMQ3O4C MN Glycoprotein IIb/IIIa receptor (GPIIb/IIIa) DMQ3O4C MT DTT DMQ3O4C MA Modulator DMQ3O4C RN Efficacy of FK633, an ultra-short acting glycoprotein IIb/IIIa antagonist on platelet preservation during and after cardiopulmonary bypass. Eur J Cardiothorac Surg. 2004 Aug;26(2):289-93. DMQ3O4C RU https://www.ncbi.nlm.nih.gov/pubmed/15296885 DMFGJNW DI DMFGJNW DMFGJNW DN FK-664 DMFGJNW MI TTTWGIX DMFGJNW MN Leukotriene receptor (LTR) DMFGJNW MT DTT DMFGJNW MA Modulator DMFGJNW RN US patent application no. 7,175,854, Pharmaceutical preparation comprising an active dispersed on a matrix. DMFGJNW RU http://www.google.com/patents/US7175854 DM524J3 DI DM524J3 DM524J3 DN FK-706 DM524J3 MI TTPLTSQ DM524J3 MN Neutrophil elastase (NE) DM524J3 MT DTT DM524J3 MA Inhibitor DM524J3 RN Neutrophil elastase inhibitors as treatment for COPD. Expert Opin Investig Drugs. 2002 Jul;11(7):965-80. DM524J3 RU https://pubmed.ncbi.nlm.nih.gov/12084007 DM7TLF6 DI DM7TLF6 DM7TLF6 DN FK-739 DM7TLF6 MI TTGN1ZA DM7TLF6 MN Angiotensin II receptor (AGTR) DM7TLF6 MT DTT DM7TLF6 MA Modulator DM7TLF6 RN The pharmacological characterization of FK 739, a new angiotensin II-receptor antagonist. Jpn J Pharmacol. 1993 Nov;63(3):335-43. DM7TLF6 RU https://pubmed.ncbi.nlm.nih.gov/8107326 DMH6QAI DI DMH6QAI DMH6QAI DN FK778 DMH6QAI MI TTLVP78 DMH6QAI MN Dihydroorotate dehydrogenase (DHODH) DMH6QAI MT DTT DMH6QAI MA Modulator DMH6QAI RN Immunosuppression with FK778 and mycophenolate mofetil in a rat cardiac transplantation model. Transplantation. 2003 Dec 15;76(11):1627-9. DMH6QAI RU https://www.ncbi.nlm.nih.gov/pubmed/14702537 DMS87T9 DI DMS87T9 DMS87T9 DN FK-838 DMS87T9 MI TTK25J1 DMS87T9 MN Adenosine A1 receptor (ADORA1) DMS87T9 MT DTT DMS87T9 MA Modulator DMS87T9 RN An orally active adenosine A1 receptor antagonist, FK838, increases renal excretion and maintains glomerular filtration rate in furosemide-resistan... Br J Pharmacol. 2003 Aug;139(8):1383-8. DMS87T9 RU https://www.ncbi.nlm.nih.gov/pubmed/12922924 DM457B1 DI DM457B1 DM457B1 DN FK-888 DM457B1 MI TTZPO1L DM457B1 MN Substance-P receptor (TACR1) DM457B1 MT DTT DM457B1 MA Antagonist DM457B1 RN Pharmacological profile of a high affinity dipeptide NK1 receptor antagonist, FK888. Br J Pharmacol. 1992 Nov;107(3):785-9. DM457B1 RU https://pubmed.ncbi.nlm.nih.gov/1282073 DMTEW80 DI DMTEW80 DMTEW80 DN FK-906 DMTEW80 MI TTB2MXP DMTEW80 MN Angiotensinogenase renin (REN) DMTEW80 MT DTT DMTEW80 MA Inhibitor DMTEW80 RN Antihypertensive efficacy of FK906, a novel human renin inhibitor. Clin Ther. 1993 May-Jun;15(3):539-48. DMTEW80 RU https://pubmed.ncbi.nlm.nih.gov/8364945 DMPD8O2 DI DMPD8O2 DMPD8O2 DN FK-960 DMPD8O2 MI TTOMNR9 DMPD8O2 MN Somatostatin receptor (SSTR) DMPD8O2 MT DTT DMPD8O2 MA Modulator DMPD8O2 RN FK960, a novel potential anti-dementia drug, enhances high K(+)-evoked release of somatostatin from rat hippocampal slices. Brain Res. 2001 Feb 16;892(1):111-7. DMPD8O2 RU https://www.ncbi.nlm.nih.gov/pubmed/11172755 DMUQN83 DI DMUQN83 DMUQN83 DN FL-386 DMUQN83 MI TTZPS91 DMUQN83 MN Dihydrothymine dehydrogenase (DPYD) DMUQN83 MT DTT DMUQN83 MA Modulator DMUQN83 RN Effects of FL-386 on faecal lipid excretion in humans. J Int Med Res. 1993 Sep-Oct;21(5):225-33. DMUQN83 RU https://pubmed.ncbi.nlm.nih.gov/8112480 DMOCMXH DI DMOCMXH DMOCMXH DN FLOSATIDIL DMOCMXH MI TT5HONZ DMOCMXH MN Calcium channel unspecific (CaC) DMOCMXH MT DTT DMOCMXH MA Antagonist DMOCMXH RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015 DMOCMXH RU https://www.accessdata.fda.gov/scripts/cder/drugsatfda/ DM3PXLZ DI DM3PXLZ DM3PXLZ DN FO-152 DM3PXLZ MI TTU6BFZ DM3PXLZ MN Candida Thymidylate synthase (Candi TMP1) DM3PXLZ MT DTT DM3PXLZ MA Modulator DM3PXLZ RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2642). DM3PXLZ RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2642 DM15LAP DI DM15LAP DM15LAP DN Fonsartan DM15LAP MI TTQVOEI DM15LAP MN Angiotensin II receptor type-2 (AGTR2) DM15LAP MT DTT DM15LAP MA Modulator DM15LAP RN Role of the angiotensin II AT2-subtype receptors in the blood pressure-lowering effect of losartan in salt-restricted rats. J Hypertens. 1998 Dec;16(12 Pt 2):2039-43. DM15LAP RU https://pubmed.ncbi.nlm.nih.gov/9886894 DMEH6LV DI DMEH6LV DMEH6LV DN Fontolizumab DMEH6LV MI TT93WF5 DMEH6LV MN Interferon-gamma (IFNG) DMEH6LV MT DTT DMEH6LV RN Emerging drugs to treat Crohn's disease. Expert Opin Emerg Drugs. 2007 Mar;12(1):49-59. DMEH6LV RU https://pubmed.ncbi.nlm.nih.gov/17355213 DMTYHK4 DI DMTYHK4 DMTYHK4 DN FOSOPAMINE DMTYHK4 MI TTEX248 DMTYHK4 MN Dopamine D2 receptor (D2R) DMTYHK4 MT DTT DMTYHK4 MA Modulator DMTYHK4 RN Development of dopaminergic drugs for the chronic treatment of congestive heart failure. J Auton Pharmacol. 1990;10 Suppl 1:s85-93. DMTYHK4 RU https://pubmed.ncbi.nlm.nih.gov/1983011 DMUD0IN DI DMUD0IN DMUD0IN DN FOZIVUDINE TIDOXIL DMUD0IN MI TT84ETX DMUD0IN MN Human immunodeficiency virus Reverse transcriptase (HIV RT) DMUD0IN MT DTT DMUD0IN MA Inhibitor DMUD0IN RN Fozivudine tidoxil as single-agent therapy decreases plasma and cell-associated viremia during acute feline immunodeficiency virus infection. J Vet Intern Med. 2011 May-Jun;25(3):413-8. DMUD0IN RU https://pubmed.ncbi.nlm.nih.gov/21457319 DML6MVP DI DML6MVP DML6MVP DN FPL-64170 DML6MVP MI TT2J34L DML6MVP MN Arachidonate 5-lipoxygenase (5-LOX) DML6MVP MT DTT DML6MVP MA Inhibitor DML6MVP RN Selective blockade of leukotriene production by a single dose of the FPL 64170XX 0.5% enema in active ulcerative colitis. Pharmacol Toxicol. 1995 Dec;77(6):371-6. DML6MVP RU https://pubmed.ncbi.nlm.nih.gov/8835361 DMTRBU4 DI DMTRBU4 DMTRBU4 DN Frakefamide DMTRBU4 MI TTKWM86 DMTRBU4 MN Opioid receptor mu (MOP) DMTRBU4 MT DTT DMTRBU4 MA Agonist DMTRBU4 RN A novel molecule (frakefamide) with peripheral opioid properties: the effects on resting ventilation compared with morphine and placebo. Anesth Analg. 2005 Mar;100(3):713-7, table of contents. DMTRBU4 RU https://pubmed.ncbi.nlm.nih.gov/15728057 DMJLEV7 DI DMJLEV7 DMJLEV7 DN FS-205-397 DMJLEV7 MI TTK0943 DMJLEV7 MN Prostaglandin G/H synthase (COX) DMJLEV7 MT DTT DMJLEV7 MA Modulator DMJLEV7 RN FS 205-397: a new antipyretic analgesic with a paracetamol-like profile of activity but lack of acute hepatotoxicity in mice. Life Sci. 1988;43(11):905-12. DMJLEV7 RU https://pubmed.ncbi.nlm.nih.gov/3261827 DMHOMFK DI DMHOMFK DMHOMFK DN G-1128 DMHOMFK MI TT6B75U DMHOMFK MN ABL messenger RNA (ABL mRNA) DMHOMFK MT DTT DMHOMFK RN Pharmaceutical Design And Development: A Molecular Biology Approach, T V Ramabhadran, 2005. Page(219). DMHOMFK RU https://books.google.com.sg/books?id=wmPsNyVMLVsC&pg=PA219&lpg=PA219&dq=%E2%80%9CG-1128%E2%80%9D+antisense&source=bl&ots=_53NgYwdeA&sig=0CKK88IXybZco5YWV-7pU8EugPs&hl=zh-CN&sa=X&ved=0CCYQ6AEwAWoVChMI8cD98f--yAIVQQSOCh24qgAR DMTNYSF DI DMTNYSF DMTNYSF DN Galarubicin DMTNYSF MI TTLM12X DMTNYSF MN Matrix metalloproteinase-2 (MMP-2) DMTNYSF MT DTT DMTNYSF MA Inhibitor DMTNYSF RN Inhibitory effect of DA-125, a new anthracyclin analog antitumor agent, on the invasion of human fibrosarcoma cells by down-regulating the matrix m... Biochem Pharmacol. 2005 Dec 19;71(1-2):21-31. DMTNYSF RU https://pubmed.ncbi.nlm.nih.gov/16271263 DMTNYSF DI DMTNYSF DMTNYSF DN Galarubicin DMTNYSF MI TT6X50U DMTNYSF MN Matrix metalloproteinase-9 (MMP-9) DMTNYSF MT DTT DMTNYSF MA Inhibitor DMTNYSF RN Inhibitory effect of DA-125, a new anthracyclin analog antitumor agent, on the invasion of human fibrosarcoma cells by down-regulating the matrix m... Biochem Pharmacol. 2005 Dec 19;71(1-2):21-31. DMTNYSF RU https://pubmed.ncbi.nlm.nih.gov/16271263 DMX0Z51 DI DMX0Z51 DMX0Z51 DN Gallium maltolate DMX0Z51 MI TTBWDI0 DMX0Z51 MN Ribonucleoside-diphosphate reductase M2 (RRM2) DMX0Z51 MT DTT DMX0Z51 MA Binder DMX0Z51 RN Gallium maltolate is a promising chemotherapeutic agent for the treatment of hepatocellular carcinoma. Anticancer Res. 2006 May-Jun;26(3A):1739-43. DMX0Z51 RU https://pubmed.ncbi.nlm.nih.gov/16827101 DMHAM2J DI DMHAM2J DMHAM2J DN Gantofiban DMHAM2J MI TT38RM1 DMHAM2J MN Glycoprotein IIb/IIIa receptor (GPIIb/IIIa) DMHAM2J MT DTT DMHAM2J MA Modulator DMHAM2J RN Enantioseparation of gantofiban precursors on chiral stationary phases of the poly-(N-acryloyl amino acid derivative)-type. J Pharm Biomed Anal. 2002 Jan 15;27(3-4):627-37. DMHAM2J RU https://www.ncbi.nlm.nih.gov/pubmed/11755763 DM8IL1U DI DM8IL1U DM8IL1U DN Gavestinel DM8IL1U MI TTZ8EM9 DM8IL1U MN Glycine receptor (GlyR) DM8IL1U MT DTT DM8IL1U MA Modulator DM8IL1U RN Glycine antagonist (gavestinel) in neuroprotection (GAIN International) in patients with acute stroke: a randomised controlled trial.GAIN International Investigators.Lancet.2000 Jun 3;355(9219):1949-54. DM8IL1U RU https://www.ncbi.nlm.nih.gov/pubmed/10859040 DM8IL1U DI DM8IL1U DM8IL1U DN Gavestinel DM8IL1U MI DEYGVN4 DM8IL1U MN UDP-glucuronosyltransferase 1A1 (UGT1A1) DM8IL1U MT DME DM8IL1U MA Metabolism DM8IL1U RN Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. DM8IL1U RU https://www.ncbi.nlm.nih.gov/pubmed/?term=19515014 DM8IL1U DI DM8IL1U DM8IL1U DN Gavestinel DM8IL1U MI DEF2WXN DM8IL1U MN UDP-glucuronosyltransferase 1A3 (UGT1A3) DM8IL1U MT DME DM8IL1U MA Metabolism DM8IL1U RN Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. DM8IL1U RU https://www.ncbi.nlm.nih.gov/pubmed/?term=19515014 DM8IL1U DI DM8IL1U DM8IL1U DN Gavestinel DM8IL1U MI DE85D2P DM8IL1U MN UDP-glucuronosyltransferase 1A9 (UGT1A9) DM8IL1U MT DME DM8IL1U MA Metabolism DM8IL1U RN Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. DM8IL1U RU https://www.ncbi.nlm.nih.gov/pubmed/?term=19515014 DMS7TC5 DI DMS7TC5 DMS7TC5 DN Geldanamycin DMS7TC5 MI TT78R5H DMS7TC5 MN Heat shock protein 90 alpha (HSP90A) DMS7TC5 MT DTT DMS7TC5 MA Inhibitor DMS7TC5 RN Heat shock protein 90 regulates the stability of MEKK3 in HEK293 cells. Cell Immunol. 2009;259(1):49-55. DMS7TC5 RU https://pubmed.ncbi.nlm.nih.gov/19560753 DMLMT5O DI DMLMT5O DMLMT5O DN Gemopatrilat DMLMT5O MI TT5TKPM DMLMT5O MN Neutral endopeptidase (MME) DMLMT5O MT DTT DMLMT5O MA Modulator DMLMT5O RN Omapatrilat.Bristol-Myers Squibb.Curr Opin Investig Drugs.2001 Oct;2(10):1414-22. DMLMT5O RU https://www.ncbi.nlm.nih.gov/pubmed/11890357 DMIUFS4 DI DMIUFS4 DMIUFS4 DN GI 181771 DMIUFS4 MI TTCG0AL DMIUFS4 MN Cholecystokinin receptor type A (CCKAR) DMIUFS4 MT DTT DMIUFS4 MA Agonist DMIUFS4 RN Gateways to clinical trials. Methods Find Exp Clin Pharmacol. 2003 Jul-Aug;25(6):483-506. DMIUFS4 RU https://pubmed.ncbi.nlm.nih.gov/12949633 DM10CBF DI DM10CBF DM10CBF DN GL-331 DM10CBF MI TT0IHXV DM10CBF MN DNA topoisomerase II (TOP2) DM10CBF MT DTT DM10CBF MA Modulator DM10CBF RN GL331, a topoisomerase II inhibitor, induces radiosensitization of human glioma cells. Anticancer Res. 2006 May-Jun;26(3A):2149-56. DM10CBF RU https://pubmed.ncbi.nlm.nih.gov/16827158 DMT1LQS DI DMT1LQS DMT1LQS DN GLENVASTATIN DMT1LQS MI TTPADOQ DMT1LQS MN HMG-CoA reductase (HMGCR) DMT1LQS MT DTT DMT1LQS MA Inhibitor DMT1LQS RN Bile acid derived HMG-CoA reductase inhibitors. Biochim Biophys Acta. 1994 Nov 29;1227(3):137-54. DMT1LQS RU https://pubmed.ncbi.nlm.nih.gov/7986821 DMC87DR DI DMC87DR DMC87DR DN GLPG-0259 DMC87DR MI TT3UJ7Z DMC87DR MN MAPK-activated protein kinase 5 (MAPKAPK5) DMC87DR MT DTT DMC87DR MA Inhibitor DMC87DR RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2096). DMC87DR RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2096 DM5JKCL DI DM5JKCL DM5JKCL DN GlycoPEGylated erythropoietin DM5JKCL MI TTAUX24 DM5JKCL MN Erythropoietin Receptor (EPOR) DM5JKCL MT DTT DM5JKCL MA Modulator DM5JKCL RN Design of Homogeneous, MonoPEGylated Erythropoietin Analogs With Preserved In Vitro Bioactivity. Exp Hematol. 2006 June; 34(6): 697-704. DM5JKCL RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1634893/ DM07VBW DI DM07VBW DM07VBW DN Glypromate DM07VBW MI TTGQUFK DM07VBW MN PI3K/AKT/mTOR pathway (PAm pathway) DM07VBW MT DTT DM07VBW MA Modulator DM07VBW RN Dendritic spine dysgenesis in Rett syndrome. Front Neuroanat. 2014; 8: 97. DM07VBW RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4159975/ DM7V9CT DI DM7V9CT DM7V9CT DN GM6001 DM7V9CT MI TTIQSC1 DM7V9CT MN Bacterial Lethal factor (Bact lef) DM7V9CT MT DTT DM7V9CT MA Inhibitor DM7V9CT RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DM7V9CT RU https://pubmed.ncbi.nlm.nih.gov/17139284 DM7V9CT DI DM7V9CT DM7V9CT DN GM6001 DM7V9CT MI TTMX39J DM7V9CT MN Matrix metalloproteinase-1 (MMP-1) DM7V9CT MT DTT DM7V9CT MA Inhibitor DM7V9CT RN Introduction of the 4-(4-bromophenyl)benzenesulfonyl group to hydrazide analogs of Ilomastat leads to potent gelatinase B (MMP-9) inhibitors with i... Bioorg Med Chem. 2008 Sep 15;16(18):8745-59. DM7V9CT RU https://pubmed.ncbi.nlm.nih.gov/18782669 DM7V9CT DI DM7V9CT DM7V9CT DN GM6001 DM7V9CT MI TTXZ0KQ DM7V9CT MN Matrix metalloproteinase-12 (MMP-12) DM7V9CT MT DTT DM7V9CT MA Inhibitor DM7V9CT RN Selective inhibition of matrix metalloproteinase isozymes and in vivo protection against emphysema by substituted gamma-keto carboxylic acids. J Med Chem. 2006 Jan 26;49(2):456-8. DM7V9CT RU https://pubmed.ncbi.nlm.nih.gov/16420030 DM7V9CT DI DM7V9CT DM7V9CT DN GM6001 DM7V9CT MI TTHY57M DM7V9CT MN Matrix metalloproteinase-13 (MMP-13) DM7V9CT MT DTT DM7V9CT MA Inhibitor DM7V9CT RN Discovery and characterization of a novel inhibitor of matrix metalloprotease-13 that reduces cartilage damage in vivo without joint fibroplasia si... J Biol Chem. 2007 Sep 21;282(38):27781-91. DM7V9CT RU https://pubmed.ncbi.nlm.nih.gov/17623656 DM7V9CT DI DM7V9CT DM7V9CT DN GM6001 DM7V9CT MI TTJ4QE7 DM7V9CT MN Matrix metalloproteinase-14 (MMP-14) DM7V9CT MT DTT DM7V9CT MA Inhibitor DM7V9CT RN Introduction of the 4-(4-bromophenyl)benzenesulfonyl group to hydrazide analogs of Ilomastat leads to potent gelatinase B (MMP-9) inhibitors with i... Bioorg Med Chem. 2008 Sep 15;16(18):8745-59. DM7V9CT RU https://pubmed.ncbi.nlm.nih.gov/18782669 DM7V9CT DI DM7V9CT DM7V9CT DN GM6001 DM7V9CT MI TTLM12X DM7V9CT MN Matrix metalloproteinase-2 (MMP-2) DM7V9CT MT DTT DM7V9CT MA Inhibitor DM7V9CT RN Introduction of the 4-(4-bromophenyl)benzenesulfonyl group to hydrazide analogs of Ilomastat leads to potent gelatinase B (MMP-9) inhibitors with i... Bioorg Med Chem. 2008 Sep 15;16(18):8745-59. DM7V9CT RU https://pubmed.ncbi.nlm.nih.gov/18782669 DM7V9CT DI DM7V9CT DM7V9CT DN GM6001 DM7V9CT MI TTYRF5E DM7V9CT MN Matrix metalloproteinase-21 (MMP-21) DM7V9CT MT DTT DM7V9CT MA Inhibitor DM7V9CT RN Selective inhibition of matrix metalloproteinase isozymes and in vivo protection against emphysema by substituted gamma-keto carboxylic acids. J Med Chem. 2006 Jan 26;49(2):456-8. DM7V9CT RU https://pubmed.ncbi.nlm.nih.gov/16420030 DM7V9CT DI DM7V9CT DM7V9CT DN GM6001 DM7V9CT MI TTUZ2L5 DM7V9CT MN Matrix metalloproteinase-3 (MMP-3) DM7V9CT MT DTT DM7V9CT MA Inhibitor DM7V9CT RN Introduction of the 4-(4-bromophenyl)benzenesulfonyl group to hydrazide analogs of Ilomastat leads to potent gelatinase B (MMP-9) inhibitors with i... Bioorg Med Chem. 2008 Sep 15;16(18):8745-59. DM7V9CT RU https://pubmed.ncbi.nlm.nih.gov/18782669 DM7V9CT DI DM7V9CT DM7V9CT DN GM6001 DM7V9CT MI TTGA1IV DM7V9CT MN Matrix metalloproteinase-8 (MMP-8) DM7V9CT MT DTT DM7V9CT MA Inhibitor DM7V9CT RN Hydroxamate inhibitors of human gelatinase B (92 kDa), Bioorg. Med. Chem. Lett. 5(4):349-352 (1995). DM7V9CT RU http://www.sciencedirect.com/science/article/pii/0960894X9500033P DM7V9CT DI DM7V9CT DM7V9CT DN GM6001 DM7V9CT MI TT6X50U DM7V9CT MN Matrix metalloproteinase-9 (MMP-9) DM7V9CT MT DTT DM7V9CT MA Inhibitor DM7V9CT RN Introduction of the 4-(4-bromophenyl)benzenesulfonyl group to hydrazide analogs of Ilomastat leads to potent gelatinase B (MMP-9) inhibitors with i... Bioorg Med Chem. 2008 Sep 15;16(18):8745-59. DM7V9CT RU https://pubmed.ncbi.nlm.nih.gov/18782669 DM9MEAY DI DM9MEAY DM9MEAY DN Gonadimmune DM9MEAY MI TT8R70G DM9MEAY MN Gonadotropin-releasing hormone receptor (GNRHR) DM9MEAY MT DTT DM9MEAY MA Modulator DM9MEAY RN A novel retro-inverso gonadotropin-releasing hormone (GnRH) immunogen elicits antibodies that neutralize the activity of native GnRH. Endocrinology. 2003 Jul;144(7):3262-9. DM9MEAY RU https://pubmed.ncbi.nlm.nih.gov/12810583 DMCXLIK DI DMCXLIK DMCXLIK DN GR-213487 DMCXLIK MI TTCYAXN DMCXLIK MN Chloride channel unspecific (ClC) DMCXLIK MT DTT DMCXLIK MA Modulator DMCXLIK RN EP patent application no. 1336602, Nitrate prodrugs able to release nitric oxide in a controlled and selective way and their use for prevention and treatment of inflammatory, ischemic and proliferative diseases. DMCXLIK RU http://www.google.com/patents/EP1336602A1?cl=en DMSV6KP DI DMSV6KP DMSV6KP DN GSK 679769 DMSV6KP MI TTZPO1L DMSV6KP MN Substance-P receptor (TACR1) DMSV6KP MT DTT DMSV6KP MA Antagonist DMSV6KP RN Emerging drugs for chemotherapy-induced emesis. Expert Opin Emerg Drugs. 2006 Mar;11(1):137-51. DMSV6KP RU https://pubmed.ncbi.nlm.nih.gov/16503832 DMTZBXQ DI DMTZBXQ DMTZBXQ DN GSK-159797 DMTZBXQ MI TT2CJVK DMTZBXQ MN Adrenergic receptor beta-2 (ADRB2) DMTZBXQ MT DTT DMTZBXQ MA Agonist DMTZBXQ RN Emerging drugs for the treatment of chronic obstructive pulmonary disease. Expert Opin Emerg Drugs. 2006 May;11(2):275-91. DMTZBXQ RU https://pubmed.ncbi.nlm.nih.gov/16634702 DMTZBXQ DI DMTZBXQ DMTZBXQ DN GSK-159797 DMTZBXQ MI TTDW3Z2 DMTZBXQ MN Telomerase messenger RNA (Telomerase mRNA) DMTZBXQ MT DTT DMTZBXQ RN Combination therapy of 2-5A antisense against telomerase RNA and cisplatin for malignant gliomas. Int J Oncol. 2001 Jun;18(6):1287-92. DMTZBXQ RU https://pubmed.ncbi.nlm.nih.gov/11351264 DM8J2AV DI DM8J2AV DM8J2AV DN GSK159802 DM8J2AV MI TT2CJVK DM8J2AV MN Adrenergic receptor beta-2 (ADRB2) DM8J2AV MT DTT DM8J2AV MA Agonist DM8J2AV RN Clinical pipeline report, company report or official report of GlaxoSmithKline (2009). DM8J2AV RU http://www.gsk.com/investors/product_pipeline/docs/gsk-pipeline-feb09.pdf DMX7DVH DI DMX7DVH DMX7DVH DN GSK163090 DMX7DVH MI TTSQIFT DMX7DVH MN 5-HT 1A receptor (HTR1A) DMX7DVH MT DTT DMX7DVH MA Antagonist DMX7DVH RN Clinical pipeline report, company report or official report of GlaxoSmithKline (2009). DMX7DVH RU http://www.gsk.com/investors/product_pipeline/docs/gsk-pipeline-feb09.pdf DMMIR1K DI DMMIR1K DMMIR1K DN GSK184072 DMMIR1K MI TTTG60L DMMIR1K MN CAP-dependent endonuclease (CDE) DMMIR1K MT DTT DMMIR1K MA Inhibitor DMMIR1K RN Synthesis of natural flutimide and analogous fully substituted pyrazine-2,6-diones, endonuclease inhibitors of influenza virus. J Org Chem. 2001 Aug 10;66(16):5504-16. DMMIR1K RU https://pubmed.ncbi.nlm.nih.gov/11485475 DMMIR1K DI DMMIR1K DMMIR1K DN GSK184072 DMMIR1K MI TTUF2HO DMMIR1K MN NAD-dependent deacetylase sirtuin-1 (SIRT1) DMMIR1K MT DTT DMMIR1K MA Activator DMMIR1K RN Clinical pipeline report, company report or official report of GlaxoSmithKline (2009). DMMIR1K RU http://www.gsk.com/investors/product_pipeline/docs/gsk-pipeline-feb09.pdf DMHZQ0T DI DMHZQ0T DMHZQ0T DN GSK2190914 DMHZQ0T MI TTDMBF5 DMHZQ0T MN Arachidonate 5-lipoxygenase activating protein (FLAP) DMHZQ0T MT DTT DMHZQ0T MA Inhibitor DMHZQ0T RN FLAP inhibitors for the treatment of inflammatory diseases. Curr Opin Investig Drugs. 2009 Nov;10(11):1163-72. DMHZQ0T RU https://pubmed.ncbi.nlm.nih.gov/19876784 DM89AV2 DI DM89AV2 DM89AV2 DN GSK2190915 DM89AV2 MI TTDMBF5 DM89AV2 MN Arachidonate 5-lipoxygenase activating protein (FLAP) DM89AV2 MT DTT DM89AV2 MA Inhibitor DM89AV2 RN Clinical pipeline report, company report or official report of GlaxoSmithKline (2009). DM89AV2 RU http://www.gsk.com/investors/product_pipeline/docs/gsk-pipeline-feb09.pdf DMBYQJH DI DMBYQJH DMBYQJH DN GSK256066 DMBYQJH MI TTZ97H5 DMBYQJH MN Phosphodiesterase 4A (PDE4A) DMBYQJH MT DTT DMBYQJH MA Inhibitor DMBYQJH RN Clinical pipeline report, company report or official report of GlaxoSmithKline (2009). DMBYQJH RU http://www.gsk.com/investors/product_pipeline/docs/gsk-pipeline-feb09.pdf DMUC9OS DI DMUC9OS DMUC9OS DN GSK-644784 DMUC9OS MI TTVKILB DMUC9OS MN Prostaglandin G/H synthase 2 (COX-2) DMUC9OS MT DTT DMUC9OS MA Inhibitor DMUC9OS RN Emerging drugs in neuropathic pain. Expert Opin Emerg Drugs. 2007 Mar;12(1):113-26. DMUC9OS RU https://pubmed.ncbi.nlm.nih.gov/17355217 DM5WRJX DI DM5WRJX DM5WRJX DN GSK-677954 DM5WRJX MI TTJ584C DM5WRJX MN Peroxisome proliferator-activated receptor alpha (PPARA) DM5WRJX MT DTT DM5WRJX MA Agonist DM5WRJX RN Emerging drugs for non-alcoholic fatty liver disease. Expert Opin Emerg Drugs. 2008 Mar;13(1):145-58. DM5WRJX RU https://pubmed.ncbi.nlm.nih.gov/18321154 DM5WRJX DI DM5WRJX DM5WRJX DN GSK-677954 DM5WRJX MI TT2JWF6 DM5WRJX MN Peroxisome proliferator-activated receptor delta (PPARD) DM5WRJX MT DTT DM5WRJX MA Agonist DM5WRJX RN Emerging drugs for non-alcoholic fatty liver disease. Expert Opin Emerg Drugs. 2008 Mar;13(1):145-58. DM5WRJX RU https://pubmed.ncbi.nlm.nih.gov/18321154 DM5WRJX DI DM5WRJX DM5WRJX DN GSK-677954 DM5WRJX MI TTZMAO3 DM5WRJX MN Peroxisome proliferator-activated receptor gamma (PPAR-gamma) DM5WRJX MT DTT DM5WRJX MA Agonist DM5WRJX RN Emerging drugs for non-alcoholic fatty liver disease. Expert Opin Emerg Drugs. 2008 Mar;13(1):145-58. DM5WRJX RU https://pubmed.ncbi.nlm.nih.gov/18321154 DMJ0ZB6 DI DMJ0ZB6 DMJ0ZB6 DN GSK-732461 DMJ0ZB6 MI TTFGZB6 DMJ0ZB6 MN Human immunodeficiency virus GAG protein (HIV gag) DMJ0ZB6 MT DTT DMJ0ZB6 RN Preventive technologies, research toward a cure, and immune-based and gene therapies. HIV Treatment Bulletin. 30 June 2013. DMJ0ZB6 RU http://i-base.info/htb/21502 DMJ0ZB6 DI DMJ0ZB6 DMJ0ZB6 DN GSK-732461 DMJ0ZB6 MI TT4NXYM DMJ0ZB6 MN Human immunodeficiency virus Negative factor (HIV nef) DMJ0ZB6 MT DTT DMJ0ZB6 RN Preventive technologies, research toward a cure, and immune-based and gene therapies. HIV Treatment Bulletin. 30 June 2013. DMJ0ZB6 RU http://i-base.info/htb/21502 DMRNJPY DI DMRNJPY DMRNJPY DN GSK835726 DMRNJPY MI TTTIBOJ DMRNJPY MN Histamine H1 receptor (H1R) DMRNJPY MT DTT DMRNJPY MA Antagonist DMRNJPY RN Clinical pipeline report, company report or official report of GlaxoSmithKline (2009). DMRNJPY RU http://www.gsk.com/investors/product_pipeline/docs/gsk-pipeline-feb09.pdf DMRNJPY DI DMRNJPY DMRNJPY DN GSK835726 DMRNJPY MI TT9JNIC DMRNJPY MN Histamine H3 receptor (H3R) DMRNJPY MT DTT DMRNJPY MA Antagonist DMRNJPY RN Clinical pipeline report, company report or official report of GlaxoSmithKline (2009). DMRNJPY RU http://www.gsk.com/investors/product_pipeline/docs/gsk-pipeline-feb09.pdf DM8J30W DI DM8J30W DM8J30W DN GSK870086 DM8J30W MI TTYRL6O DM8J30W MN Glucocorticoid receptor (NR3C1) DM8J30W MT DTT DM8J30W MA Modulator DM8J30W RN CN patent application no. 102388025, Pyrimidopyridazine derivatives useful as p38 mapk inhibitors. DM8J30W RU http://www.google.com/patents/CN102388025A?cl=en DMLFCNY DI DMLFCNY DMLFCNY DN GT-389255 DMLFCNY MI TT3GKN5 DMLFCNY MN Lipase unspecific (LIP) DMLFCNY MT DTT DMLFCNY MA Inhibitor DMLFCNY RN Obesity drugs in clinical development. Curr Opin Investig Drugs. 2006 Apr;7(4):312-8. DMLFCNY RU https://pubmed.ncbi.nlm.nih.gov/16625817 DMZD023 DI DMZD023 DMZD023 DN GV-150013 DMZD023 MI TTVFO0U DMZD023 MN Gastrin/cholecystokinin type B receptor (CCKBR) DMZD023 MT DTT DMZD023 MA Antagonist DMZD023 RN The role of cholecystokinin (CCK), CCK-A or CCK-B receptor antagonists in the spontaneous preference for drugs of abuse (alcohol or cocaine) in naive rats. Methods Find Exp Clin Pharmacol. 1998 Oct;20(8):679-97. DMZD023 RU https://pubmed.ncbi.nlm.nih.gov/9922984 DMFN21T DI DMFN21T DMFN21T DN GV-196771 DMFN21T MI TTZ8EM9 DMFN21T MN Glycine receptor (GlyR) DMFN21T MT DTT DMFN21T MA Modulator DMFN21T RN First time in human for GV196771: interspecies scaling applied on dose selection. J Clin Pharmacol. 1999 Jun;39(6):560-6. DMFN21T RU https://pubmed.ncbi.nlm.nih.gov/10354959 DMQ92WF DI DMQ92WF DMQ92WF DN GW 468816 DMQ92WF MI TTZ8EM9 DMQ92WF MN Glycine receptor (GlyR) DMQ92WF MT DTT DMQ92WF MA Modulator DMQ92WF RN A double-blind, placebo-controlled trial of the NMDA glycine site antagonist, GW468816, for prevention of relapse to smoking in females.J Clin Psychopharmacol.2011 Oct;31(5):597-602. DMQ92WF RU https://www.ncbi.nlm.nih.gov/pubmed/21869693 DMOIL29 DI DMOIL29 DMOIL29 DN GW-275919 DMOIL29 MI TTS64P2 DMOIL29 MN Androgen receptor (AR) DMOIL29 MT DTT DMOIL29 MA Modulator DMOIL29 RN Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800010426) DMOIL29 RU http://adisinsight.springer.com/drugs/800010426 DMZ2OBD DI DMZ2OBD DMZ2OBD DN GW-493838 DMZ2OBD MI TTK25J1 DMZ2OBD MN Adenosine A1 receptor (ADORA1) DMZ2OBD MT DTT DMZ2OBD MA Modulator DMZ2OBD RN A1 adenosine receptor agonists and their potential therapeutic applications. Expert Opin Investig Drugs. 2008 Dec;17(12):1901-10. DMZ2OBD RU https://pubmed.ncbi.nlm.nih.gov/19012505 DM1FIN9 DI DM1FIN9 DM1FIN9 DN GW-559090 DM1FIN9 MI TTHIZP9 DM1FIN9 MN Integrin alpha-5 (ITGA5) DM1FIN9 MT DTT DM1FIN9 MA Antagonist DM1FIN9 RN Roles of integrin activation in eosinophil function and the eosinophilic inflammation of asthma. J Leukoc Biol. 2008 January; 83(1): 1-12. DM1FIN9 RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2859217/ DMKC0J5 DI DMKC0J5 DMKC0J5 DN GW-766994 DMKC0J5 MI TTRQJTC DMKC0J5 MN C-X-C chemokine receptor type 7 (ACKR3) DMKC0J5 MT DTT DMKC0J5 MA Antagonist DMKC0J5 RN Safety and efficacy of an oral CCR3 antagonist in patients with asthma and eosinophilic bronchitis: a randomized, placebo-controlled clinical trial. Clin Exp Allergy. 2014 Apr;44(4):508-16. DMKC0J5 RU https://pubmed.ncbi.nlm.nih.gov/24286456 DMKC0J5 DI DMKC0J5 DMKC0J5 DN GW-766994 DMKC0J5 MI DE4LYSA DMKC0J5 MN Cytochrome P450 3A4 (CYP3A4) DMKC0J5 MT DME DMKC0J5 MA Metabolism DMKC0J5 RN GW766994 CCR3 receptor antagonist. DMKC0J5 RU https://mrc.ukri.org/funding/browse/mrc-industry-asset-sharing-initiative-2016/compounds-list-2016/ccr3-receptor-antagonist/ DMLC154 DI DMLC154 DMLC154 DN GW842470X DMLC154 MI TTV5CGO DMLC154 MN Phosphodiesterase 4 (PDE4) DMLC154 MT DTT DMLC154 MA Inhibitor DMLC154 RN Emerging drugs for atopic dermatitis. Expert Opin Emerg Drugs. 2009 Mar;14(1):165-79. DMLC154 RU https://pubmed.ncbi.nlm.nih.gov/19216704 DMAXRBI DI DMAXRBI DMAXRBI DN GW876008 DMAXRBI MI TT7EFHR DMAXRBI MN Corticotropin-releasing factor receptor 1 (CRHR1) DMAXRBI MT DTT DMAXRBI MA Antagonist DMAXRBI RN Novel drugs and therapeutic targets for severe mood disorders. Neuropsychopharmacology. 2008 Aug;33(9):2080-92. DMAXRBI RU https://pubmed.ncbi.nlm.nih.gov/18172433 DMMZQVS DI DMMZQVS DMMZQVS DN GYKI-16084 DMMZQVS MI TT34BHT DMMZQVS MN Adrenergic receptor alpha-1D (ADRA1D) DMMZQVS MT DTT DMMZQVS MA Antagonist DMMZQVS RN A novel approach to the treatment of benign prostatic hyperplasia. BJU Int. 2006 Jun;97(6):1252-5. DMMZQVS RU https://pubmed.ncbi.nlm.nih.gov/16686721 DMMZQVS DI DMMZQVS DMMZQVS DN GYKI-16084 DMMZQVS MI TT2NUT5 DMMZQVS MN Adrenergic receptor alpha-2C (ADRA2C) DMMZQVS MT DTT DMMZQVS MA Antagonist DMMZQVS RN A novel approach to the treatment of benign prostatic hyperplasia. BJU Int. 2006 Jun;97(6):1252-5. DMMZQVS RU https://pubmed.ncbi.nlm.nih.gov/16686721 DMYJ9CF DI DMYJ9CF DMYJ9CF DN H-409/22 DMYJ9CF MI TTRK9JT DMYJ9CF MN Neuropeptide Y receptor type 1 (NPY1R) DMYJ9CF MT DTT DMYJ9CF MA Antagonist DMYJ9CF RN In vivo characterization of the novel neuropeptide Y Y1 receptor antagonist H 409/22. J Cardiovasc Pharmacol. 2000 Oct;36(4):516-25. DMYJ9CF RU https://pubmed.ncbi.nlm.nih.gov/11026655 DMPQSE4 DI DMPQSE4 DMPQSE4 DN HCV-796 DMPQSE4 MI TTMVBWH DMPQSE4 MN Hepatitis C virus RNA-directed RNA polymerase (HCV NS5B) DMPQSE4 MT DTT DMPQSE4 MA Inhibitor DMPQSE4 RN Emerging drugs for hepatitis C. Expert Opin Emerg Drugs. 2008 Mar;13(1):1-19. DMPQSE4 RU https://pubmed.ncbi.nlm.nih.gov/18321145 DMWH4CY DI DMWH4CY DMWH4CY DN HE-2000 DMWH4CY MI TTS64P2 DMWH4CY MN Androgen receptor (AR) DMWH4CY MT DTT DMWH4CY MA Inhibitor DMWH4CY RN Dehydroepiandrosterone upregulates neural androgen receptor level and transcriptional activity. J Neurobiol. 2003 Nov;57(2):163-71. DMWH4CY RU https://pubmed.ncbi.nlm.nih.gov/14556282 DM5JZW2 DI DM5JZW2 DM5JZW2 DN Her-2-Bi-armed ATC DM5JZW2 MI TT6EO5L DM5JZW2 MN Erbb2 tyrosine kinase receptor (HER2) DM5JZW2 MT DTT DM5JZW2 RN Cancer therapy with bispecific antibodies: Clinical experience. Curr Opin Mol Ther. 2010 June; 12(3): 340-349. DM5JZW2 RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3785321/ DMIJSB3 DI DMIJSB3 DMIJSB3 DN HMR-1426 DMIJSB3 MI TT63CB1 DMIJSB3 MN Food intake (FI) DMIJSB3 MT DTT DMIJSB3 MA Modulator DMIJSB3 RN Analysis of the anorectic efficacy of HMR1426 in rodents and its effects on gastric emptying in rats. Int J Obes Relat Metab Disord. 2004 Feb;28(2):211-21. DMIJSB3 RU https://pubmed.ncbi.nlm.nih.gov/14663491 DMYJ1ZB DI DMYJ1ZB DMYJ1ZB DN HN-10200 DMYJ1ZB MI TTUST1O DMYJ1ZB MN Phosphodiesterase (PDE) DMYJ1ZB MT DTT DMYJ1ZB MA Inhibitor DMYJ1ZB RN HN-10200 causes endothelium-independent relaxations in isolated canine arteries. Cardiovasc Drugs Ther. 1992 Apr;6(2):159-65. DMYJ1ZB RU https://pubmed.ncbi.nlm.nih.gov/1382554 DMUMGCY DI DMUMGCY DMUMGCY DN HP-290 DMUMGCY MI TT1RS9F DMUMGCY MN Acetylcholinesterase (AChE) DMUMGCY MT DTT DMUMGCY MA Inhibitor DMUMGCY RN NXX-066 in patients with Alzheimer's disease: a bridging study. Life Sci. 1999;64(14):1215-21. DMUMGCY RU https://pubmed.ncbi.nlm.nih.gov/10210264 DM51GZS DI DM51GZS DM51GZS DN HR325 DM51GZS MI TTLVP78 DM51GZS MN Dihydroorotate dehydrogenase (DHODH) DM51GZS MT DTT DM51GZS MA Modulator DM51GZS RN In vitro and in Vivo inhibition of immunoglobulin secretion by the immunosuppressive compound HR325 is reversed by exogenous uridine. Scand J Immunol. 2002 Jul;56(1):35-42. DM51GZS RU https://www.ncbi.nlm.nih.gov/pubmed/12100469 DM1PJ0V DI DM1PJ0V DM1PJ0V DN HSR-609 DM1PJ0V MI TTTIBOJ DM1PJ0V MN Histamine H1 receptor (H1R) DM1PJ0V MT DTT DM1PJ0V MA Antagonist DM1PJ0V RN Studies on the novel antiallergic agent HSR-609: its penetration into the central nervous system in mice and guinea pigs and its selectivity for the histamine H1-receptor. Jpn J Pharmacol. 1997 Apr;73(4):291-8. DM1PJ0V RU https://pubmed.ncbi.nlm.nih.gov/9165365 DM1LVRP DI DM1LVRP DM1LVRP DN IC-747 DM1LVRP MI TT48WR6 DM1LVRP MN Integrin alpha-L (ITGAL) DM1LVRP MT DTT DM1LVRP MA Antagonist DM1LVRP RN HECA-452+ T Cells Migrate Through Superficial Vascular Plexus but Not Through Deep Vascular Plexus Endothelium. Journal of Investigative Dermatology. 04/1997; 108(3):343-8. DM1LVRP RU http://www.nature.com/jid/journal/v121/n5/full/5602003a.html#tbl3 DMKUVZO DI DMKUVZO DMKUVZO DN ICI-170809 DMKUVZO MI TTYSN63 DMKUVZO MN 5-HT 2 receptor (5HT2R) DMKUVZO MT DTT DMKUVZO MA Modulator DMKUVZO RN 5-HT2 receptor blockade by ICI 170,809 does not affect the inhibitory effect of the 5-HT1A receptor ligand gepirone on neuroleptic-induced catalepsy. Braz J Med Biol Res. 1994 Oct;27(10):2437-41. DMKUVZO RU https://pubmed.ncbi.nlm.nih.gov/7640635 DMY8X6Q DI DMY8X6Q DMY8X6Q DN ICI-192605 DMY8X6Q MI TT2O84V DMY8X6Q MN Thromboxane A2 receptor (TBXA2R) DMY8X6Q MT DTT DMY8X6Q MA Antagonist DMY8X6Q RN The effects of thromboxane receptor blockade on platelet aggregation and digital skin blood flow in patients with secondary Raynaud's syndrome. Rheumatol Int. 1991;11(4-5):163-8. DMY8X6Q RU https://pubmed.ncbi.nlm.nih.gov/1838424 DM3R8TX DI DM3R8TX DM3R8TX DN ICI-D-8731 DM3R8TX MI TTGN1ZA DM3R8TX MN Angiotensin II receptor (AGTR) DM3R8TX MT DTT DM3R8TX MA Modulator DM3R8TX RN Vasomotor responses in cyclosporin A-treated rats after chronic angiotensin blockade. Hypertension. 1994 Jun;23(6 Pt 2):832-7. DM3R8TX RU https://pubmed.ncbi.nlm.nih.gov/8206613 DM5WUK9 DI DM5WUK9 DM5WUK9 DN Icopezil maleate DM5WUK9 MI TT1RS9F DM5WUK9 MN Acetylcholinesterase (AChE) DM5WUK9 MT DTT DM5WUK9 MA Inhibitor DM5WUK9 RN A docking score function for estimating ligand-protein interactions: application to acetylcholinesterase inhibition. J Med Chem. 2004 Oct 21;47(22):5492-500. DM5WUK9 RU https://pubmed.ncbi.nlm.nih.gov/15481986 DMILUHA DI DMILUHA DMILUHA DN IDEC-151 DMILUHA MI TTN2JFW DMILUHA MN T-cell surface glycoprotein CD4 (CD4) DMILUHA MT DTT DMILUHA RN Comparative pharmacodynamics of keliximab and clenoliximab in transgenic mice bearing human CD4. J Pharmacol Exp Ther. 2000 Apr;293(1):33-41. DMILUHA RU https://pubmed.ncbi.nlm.nih.gov/10734150 DM7O0UR DI DM7O0UR DM7O0UR DN Idrapril DM7O0UR MI TTL69WB DM7O0UR MN Angiotensin-converting enzyme (ACE) DM7O0UR MT DTT DM7O0UR MA Inhibitor DM7O0UR RN Pharmacology of idrapril: a new class of angiotensin converting enzyme inhibitors. J Cardiovasc Pharmacol. 1992 Jul;20(1):139-46. DM7O0UR RU https://pubmed.ncbi.nlm.nih.gov/1383623 DMRPBJW DI DMRPBJW DMRPBJW DN IDX375 DMRPBJW MI TTMVBWH DMRPBJW MN Hepatitis C virus RNA-directed RNA polymerase (HCV NS5B) DMRPBJW MT DTT DMRPBJW MA Inhibitor DMRPBJW RN Therapy with amineptine, a dopamine reuptake inhibitor, in patients with major depression. Indian J Psychiatry. 1997 Apr;39(2):147-53. DMRPBJW RU https://pubmed.ncbi.nlm.nih.gov/21584062 DMOG1LX DI DMOG1LX DMOG1LX DN IGN-101 DMOG1LX MI TTZ8WH4 DMOG1LX MN Tumor-associated calcium signal transducer 1 (EPCAM) DMOG1LX MT DTT DMOG1LX RN Drug evaluation: IGN-101--an anti-EpCAM murine antibody vaccine for cancer. Curr Opin Mol Ther. 2006 Aug;8(4):358-65. DMOG1LX RU https://pubmed.ncbi.nlm.nih.gov/16955700 DMU4N1O DI DMU4N1O DMU4N1O DN IGN-2098 DMU4N1O MI TTQHJ1K DMU4N1O MN Histamine H2 receptor (H2R) DMU4N1O MT DTT DMU4N1O MA Antagonist DMU4N1O RN Effects of IGN-2098, a new histamine H2-receptor antagonist, on gastric secretion and gastric and duodenal lesions induced in rats. Comparison with roxatidine. Nihon Yakurigaku Zasshi. 1992 Mar;99(3):167-80. DMU4N1O RU https://pubmed.ncbi.nlm.nih.gov/1354631 DMQ2ULV DI DMQ2ULV DMQ2ULV DN Imitrodast DMQ2ULV MI TTKNWZ4 DMQ2ULV MN Thromboxane-A synthase (TBXAS1) DMQ2ULV MT DTT DMQ2ULV MA Inhibitor DMQ2ULV RN RS-5186, a novel thromboxane synthetase inhibitor with a potent and extended duration of action. Thromb Res. 1988 Sep 1;51(5):507-20. DMQ2ULV RU https://pubmed.ncbi.nlm.nih.gov/3175990 DMRHZBD DI DMRHZBD DMRHZBD DN INCB19602 DMRHZBD MI TTWNV8U DMRHZBD MN Nicotinic acid receptor (HCAR2) DMRHZBD MT DTT DMRHZBD MA Modulator DMRHZBD RN DOI: 10.1038/scibx.2010.313 DMRHZBD RU http://www.nature.com/scibx/journal/v3/n10/full/scibx.2010.313.html DMNRQA9 DI DMNRQA9 DMNRQA9 DN INCB47986 DMNRQA9 MI TT6DM01 DMNRQA9 MN Janus kinase 1 (JAK-1) DMNRQA9 MT DTT DMNRQA9 MA Inhibitor DMNRQA9 RN Selective JAK inhibitors in development for rheumatoid arthritis. Expert Opin Investig Drugs. 2014 Aug;23(8):1067-77. DMNRQA9 RU https://pubmed.ncbi.nlm.nih.gov/24818516 DMS56UD DI DMS56UD DMS56UD DN Indeglitazar DMS56UD MI TTJ584C DMS56UD MN Peroxisome proliferator-activated receptor alpha (PPARA) DMS56UD MT DTT DMS56UD MA Agonist DMS56UD RN Scaffold-based discovery of indeglitazar, a PPAR pan-active anti-diabetic agent. Proc Natl Acad Sci U S A. 2009 Jan 6;106(1):262-7. DMS56UD RU https://pubmed.ncbi.nlm.nih.gov/19116277 DMS56UD DI DMS56UD DMS56UD DN Indeglitazar DMS56UD MI TT2JWF6 DMS56UD MN Peroxisome proliferator-activated receptor delta (PPARD) DMS56UD MT DTT DMS56UD MA Agonist DMS56UD RN Scaffold-based discovery of indeglitazar, a PPAR pan-active anti-diabetic agent. Proc Natl Acad Sci U S A. 2009 Jan 6;106(1):262-7. DMS56UD RU https://pubmed.ncbi.nlm.nih.gov/19116277 DMS56UD DI DMS56UD DMS56UD DN Indeglitazar DMS56UD MI TTZMAO3 DMS56UD MN Peroxisome proliferator-activated receptor gamma (PPAR-gamma) DMS56UD MT DTT DMS56UD MA Agonist DMS56UD RN Scaffold-based discovery of indeglitazar, a PPAR pan-active anti-diabetic agent. Proc Natl Acad Sci U S A. 2009 Jan 6;106(1):262-7. DMS56UD RU https://pubmed.ncbi.nlm.nih.gov/19116277 DMJM38Q DI DMJM38Q DMJM38Q DN INGN-234 DMJM38Q MI TT7SBF5 DMJM38Q MN Cellular tumor antigen p53 (TP53) DMJM38Q MT DTT DMJM38Q MA Suppressor DMJM38Q RN Prevent Oral Cancer With Mouthwash. Introgen Therapeutics. DMJM38Q RU http://www.medgadget.com/2005/11/prevent_oral_ca.html DM6HDO3 DI DM6HDO3 DM6HDO3 DN INOGATRAN DM6HDO3 MI TT6L509 DM6HDO3 MN Coagulation factor IIa (F2) DM6HDO3 MT DTT DM6HDO3 MA Modulator DM6HDO3 RN Inogatran, a novel direct low molecular weight thrombin inhibitor, given with, but not after, tissue-plasminogen activator, improves thrombolysis. J Pharmacol Exp Ther. 1996 Jun;277(3):1276-83. DM6HDO3 RU https://www.ncbi.nlm.nih.gov/pubmed/8667188 DMSATO0 DI DMSATO0 DMSATO0 DN IO-21 DMSATO0 MI TT9GOIR DMSATO0 MN Streptococcus Diphtheria protein (Stre DIPP) DMSATO0 MT DTT DMSATO0 MA Modulator DMSATO0 RN Interplay between Longitudinal and Transverse Contrasts in Fe3O4 Nanoplates with (111) Exposed Surfaces. ACS Nano. 2014 August 26; 8(8): 7976-7985. DMSATO0 RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4568839/ DM4WJDK DI DM4WJDK DM4WJDK DN IPENOXAZONE DM4WJDK MI TTAN6JD DM4WJDK MN Glutamate receptor AMPA (GRIA) DM4WJDK MT DTT DM4WJDK MA Modulator DM4WJDK RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015 DM4WJDK RU https://www.accessdata.fda.gov/scripts/cder/drugsatfda/ DMLQWFA DI DMLQWFA DMLQWFA DN IS-159 DMLQWFA MI TTK8CXU DMLQWFA MN 5-HT 1B receptor (HTR1B) DMLQWFA MT DTT DMLQWFA MA Modulator DMLQWFA RN Pronounced effect of caprylocaproyl macrogolglycerides on nasal absorption of IS-159, a peptide serotonin 1B/1D-receptor agonist. Clin Pharmacol Ther. 2000 Aug;68(2):114-21. DMLQWFA RU https://www.ncbi.nlm.nih.gov/pubmed/10976542 DMLQWFA DI DMLQWFA DMLQWFA DN IS-159 DMLQWFA MI TT6MSOK DMLQWFA MN 5-HT 1D receptor (HTR1D) DMLQWFA MT DTT DMLQWFA MA Modulator DMLQWFA RN Pronounced effect of caprylocaproyl macrogolglycerides on nasal absorption of IS-159, a peptide serotonin 1B/1D-receptor agonist. Clin Pharmacol Ther. 2000 Aug;68(2):114-21. DMLQWFA RU https://www.ncbi.nlm.nih.gov/pubmed/10976542 DMURWPH DI DMURWPH DMURWPH DN ISIS 104838 DMURWPH MI TTC97NF DMURWPH MN TNFA messenger RNA (TNF mRNA) DMURWPH MT DTT DMURWPH RN Design and development of antisense drugs. Expert Opin. Drug Discov. 2008 3(10):1189-1207. DMURWPH RU http://www.informahealthcare.com/doi/abs/10.1517/17460441.3.10.1177 DMGZV7U DI DMGZV7U DMGZV7U DN ISIS 14803 DMGZV7U MI TTXWCK2 DMGZV7U MN Hepatitis C virus Internal ribosome entry site messenger RNA (HCV IRES mRNA) DMGZV7U MT DTT DMGZV7U RN Design and development of antisense drugs. Expert Opin. Drug Discov. 2008 3(10):1189-1207. DMGZV7U RU http://www.informahealthcare.com/doi/abs/10.1517/17460441.3.10.1177 DMR2STB DI DMR2STB DMR2STB DN ISIS 2105 DMR2STB MI TTXQPKC DMR2STB MN Human papillomavirus E2 transactivator messenger RNA (HPV E2 mRNA) DMR2STB MT DTT DMR2STB RN US patent application no. 5,665,580, Antisense oligonucleotide inhibition of papillomavirus transformed cells. DMR2STB RU http://www.patentbuddy.com/Patent/5665580?ft=true&sr=true DMEMKIS DI DMEMKIS DMEMKIS DN ISIS 2503 DMEMKIS MI TT28ZON DMEMKIS MN H-ras messenger RNA (HRAS mRNA) DMEMKIS MT DTT DMEMKIS RN A phase I trial of ISIS 2503, an antisense inhibitor of H-ras, in combination with gemcitabine in patients with advanced cancer. Clin Cancer Res. 2003 Jan;9(1):115-23. DMEMKIS RU https://pubmed.ncbi.nlm.nih.gov/12538459 DMZFS69 DI DMZFS69 DMZFS69 DN ISIS 3521 DMZFS69 MI TTFJ8Q1 DMZFS69 MN Protein kinase C alpha (PRKCA) DMZFS69 MT DTT DMZFS69 MA Modulator DMZFS69 RN Phase II study of PKC-alpha antisense oligonucleotide aprinocarsen in combination with gemcitabine and carboplatin in patients with advanced non-small cell lung cancer.Lung Cancer.2006 May;52(2):173-80. DMZFS69 RU https://www.ncbi.nlm.nih.gov/pubmed/16507327 DMKY2UE DI DMKY2UE DMKY2UE DN Ispronicline DMKY2UE MI TTL1ATN DMKY2UE MN Neuronal acetylcholine receptor alpha-4/beta-2 (CHRNA4/B2) DMKY2UE MT DTT DMKY2UE MA Modulator DMKY2UE RN Ispronicline: a novel alpha4beta2 nicotinic acetylcholine receptor-selective agonist with cognition-enhancing and neuroprotective properties. J Mol Neurosci. 2006;30(1-2):19-20. DMKY2UE RU https://www.ncbi.nlm.nih.gov/pubmed/17192610 DMWN09H DI DMWN09H DMWN09H DN Istaroxime DMWN09H MI TTQ38E9 DMWN09H MN Sodium/potassium-transporting ATPase (SPT ATPase) DMWN09H MT DTT DMWN09H MA Inhibitor DMWN09H RN Novel analogues of istaroxime, a potent inhibitor of Na+,K+-ATPase: synthesis and structure-activity relationship. J Med Chem. 2008 Aug 14;51(15):4601-8. DMWN09H RU https://pubmed.ncbi.nlm.nih.gov/18637667 DM4TE8R DI DM4TE8R DM4TE8R DN IX207-887 DM4TE8R MI TTPM6HI DM4TE8R MN Interleukin-1 alpha (IL1A) DM4TE8R MT DTT DM4TE8R MA Modulator DM4TE8R RN Inhibition of interleukin-1 release by IX 207-887. Agents Actions. 1990 Jun;30(3-4):350-62. DM4TE8R RU https://pubmed.ncbi.nlm.nih.gov/2386108 DM5E6MK DI DM5E6MK DM5E6MK DN J-104132 DM5E6MK MI TTKRD0G DM5E6MK MN Endothelin A receptor (EDNRA) DM5E6MK MT DTT DM5E6MK MA Modulator DM5E6MK RN Pharmacological properties of J-104132 (L-753,037), a potent, orally active, mixed ETA/ETB endothelin receptor antagonist. J Pharmacol Exp Ther. 1999 Jun;289(3):1262-70. DM5E6MK RU https://pubmed.ncbi.nlm.nih.gov/10336515 DM5E6MK DI DM5E6MK DM5E6MK DN J-104132 DM5E6MK MI TT3ZTGU DM5E6MK MN Endothelin B receptor (EDNRB) DM5E6MK MT DTT DM5E6MK MA Modulator DM5E6MK RN Pharmacological properties of J-104132 (L-753,037), a potent, orally active, mixed ETA/ETB endothelin receptor antagonist. J Pharmacol Exp Ther. 1999 Jun;289(3):1262-70. DM5E6MK RU https://pubmed.ncbi.nlm.nih.gov/10336515 DMV3UN4 DI DMV3UN4 DMV3UN4 DN JTC-801 DMV3UN4 MI TTNT7K8 DMV3UN4 MN Nociceptin receptor (OPRL1) DMV3UN4 MT DTT DMV3UN4 MA Antagonist DMV3UN4 RN Nociceptin receptor antagonist JTC-801 inhibits nitrous oxide-induced analgesia in mice. J Anesth. 2009;23(2):301-3. DMV3UN4 RU https://pubmed.ncbi.nlm.nih.gov/19444578 DM1BQFY DI DM1BQFY DM1BQFY DN JTE-607 DM1BQFY MI TTXM6JN DM1BQFY MN Cytokine receptor unspecific (CRF) DM1BQFY MT DTT DM1BQFY MA Inhibitor DM1BQFY RN JTE-607, a novel inflammatory cytokine synthesis inhibitor without immunosuppression, protects from endotoxin shock in mice. Inflamm Res. 1999 Aug;48(8):461-8. DM1BQFY RU https://pubmed.ncbi.nlm.nih.gov/10493164 DMQRKH4 DI DMQRKH4 DMQRKH4 DN JTH-601 DMQRKH4 MI TT34BHT DMQRKH4 MN Adrenergic receptor alpha-1D (ADRA1D) DMQRKH4 MT DTT DMQRKH4 MA Antagonist DMQRKH4 RN Effect of JTH-601, a novel alpha(1)-adrenoceptor antagonist, on prostate function in dogs. Eur J Pharmacol. 2000 Apr 7;394(1):123-30. DMQRKH4 RU https://pubmed.ncbi.nlm.nih.gov/10771044 DMQRKH4 DI DMQRKH4 DMQRKH4 DN JTH-601 DMQRKH4 MI TT2NUT5 DMQRKH4 MN Adrenergic receptor alpha-2C (ADRA2C) DMQRKH4 MT DTT DMQRKH4 MA Antagonist DMQRKH4 RN Effect of JTH-601, a novel alpha(1)-adrenoceptor antagonist, on prostate function in dogs. Eur J Pharmacol. 2000 Apr 7;394(1):123-30. DMQRKH4 RU https://pubmed.ncbi.nlm.nih.gov/10771044 DMB0V5Y DI DMB0V5Y DMB0V5Y DN JTK-003 DMB0V5Y MI TT79JGK DMB0V5Y MN Mycobacterium RNA polymerase (MycB RNAP) DMB0V5Y MT DTT DMB0V5Y MA Inhibitor DMB0V5Y RN Antiviral Therapy for Hepatitis C Virus: Beyond the Standard of Care. Viruses. 2010 April; 2(4): 826-866. DMB0V5Y RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3185663/ DM29C6S DI DM29C6S DM29C6S DN JTP-2942 DM29C6S MI TT4J8MF DM29C6S MN Thyrotropin-releasing hormone receptor (TRHR) DM29C6S MT DTT DM29C6S MA Modulator DM29C6S RN Effect of JTP-2942, a novel thyrotropin-releasing hormone analogue, on pentobarbital-induced anesthesia in rats. Eur J Pharmacol. 1995 Mar 24;276(1-2):177-82. DM29C6S RU https://pubmed.ncbi.nlm.nih.gov/7781687 DMI0UJS DI DMI0UJS DMI0UJS DN JTP-4819 DMI0UJS MI TTNGKET DMI0UJS MN Prolyl endopeptidase (PREP) DMI0UJS MT DTT DMI0UJS MA Modulator DMI0UJS RN A novel prolyl endopeptidase inhibitor, JTP-4819, with potential for treating Alzheimer's disease. Behav Brain Res. 1997 Feb;83(1-2):147-51. DMI0UJS RU https://pubmed.ncbi.nlm.nih.gov/9062674 DM35CQ4 DI DM35CQ4 DM35CQ4 DN JTS-653 DM35CQ4 MI TTMI6F5 DM35CQ4 MN Transient receptor potential cation channel V1 (TRPV1) DM35CQ4 MT DTT DM35CQ4 MA Antagonist DM35CQ4 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 507). DM35CQ4 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=507 DMJ1ZTB DI DMJ1ZTB DMJ1ZTB DN JTT-811 DMJ1ZTB MI TTFBNVI DMJ1ZTB MN Aldose reductase (AKR1B1) DMJ1ZTB MT DTT DMJ1ZTB MA Inhibitor DMJ1ZTB RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2768). DMJ1ZTB RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2768 DMM8UNL DI DMM8UNL DMM8UNL DN JTV-506 DMM8UNL MI TT1VOHK DMM8UNL MN Potassium channel unspecific (KC) DMM8UNL MT DTT DMM8UNL MA Opener DMM8UNL RN Effects of the new potassium channel opener JTV-506 on coronary vessels in vitro and in vivo. Arzneimittelforschung. 1999 Mar;49(3):199-206. DMM8UNL RU https://pubmed.ncbi.nlm.nih.gov/10219462 DM7IP8U DI DM7IP8U DM7IP8U DN KB-5492 DM7IP8U MI TT5TPI6 DM7IP8U MN Opioid receptor sigma 1 (OPRS1) DM7IP8U MT DTT DM7IP8U MA Antagonist DM7IP8U RN Sigma receptor-mediated effects of a new antiulcer agent, KB-5492, on experimental gastric mucosal lesions and gastric alkaline secretion in rats. J Pharmacol Exp Ther. 1994 May;269(2):799-805. DM7IP8U RU https://pubmed.ncbi.nlm.nih.gov/8182548 DMOITN2 DI DMOITN2 DMOITN2 DN KC-11458 DMOITN2 MI TT953CX DMOITN2 MN Motilin receptor (MLNR) DMOITN2 MT DTT DMOITN2 MA Modulator DMOITN2 RN Effect of the motilin agonist KC 11458 on gastric emptying in diabetic gastroparesis. Aliment Pharmacol Ther. 2004 Aug 1;20(3):333-8. DMOITN2 RU https://pubmed.ncbi.nlm.nih.gov/15274670 DMBX6C7 DI DMBX6C7 DMBX6C7 DN KC706 DMBX6C7 MI TTYT93M DMBX6C7 MN MAP kinase p38 (MAPK12) DMBX6C7 MT DTT DMBX6C7 MA Inhibitor DMBX6C7 RN KC706, an Oral p38 MAP Kinase Inhibitor, Increases HDL-C. Circulation. 2007;116:II_126. DMBX6C7 RU http://circ.ahajournals.org/cgi/content/meeting_abstract/116/16_MeetingAbstracts/II_126-c DMC30N4 DI DMC30N4 DMC30N4 DN KCO-912 DMC30N4 MI TT1VOHK DMC30N4 MN Potassium channel unspecific (KC) DMC30N4 MT DTT DMC30N4 MA Agonist DMC30N4 RN KCO912: a potent and selective opener of ATP-dependent potassium (K(ATP)) channels which suppresses airways hyperreactivity at doses devoid of card... Naunyn Schmiedebergs Arch Pharmacol. 2002 Mar;365(3):220-30. DMC30N4 RU https://pubmed.ncbi.nlm.nih.gov/11882918 DMX9M53 DI DMX9M53 DMX9M53 DN KDS-2000 DMX9M53 MI TT6OEDT DMX9M53 MN Cannabinoid receptor 1 (CB1) DMX9M53 MT DTT DMX9M53 MA Agonist DMX9M53 RN Emerging drugs in neuropathic pain. Expert Opin Emerg Drugs. 2007 Mar;12(1):113-26. DMX9M53 RU https://pubmed.ncbi.nlm.nih.gov/17355217 DMN4BIA DI DMN4BIA DMN4BIA DN KN-38-7271 DMN4BIA MI TT6OEDT DMN4BIA MN Cannabinoid receptor 1 (CB1) DMN4BIA MT DTT DMN4BIA MA Modulator DMN4BIA RN BAY 38-7271: a novel highly selective and highly potent cannabinoid receptor agonist for the treatment of traumatic brain injury.CNS Drug Rev.2003 Winter;9(4):343-58. DMN4BIA RU https://www.ncbi.nlm.nih.gov/pubmed/14647528 DMN4BIA DI DMN4BIA DMN4BIA DN KN-38-7271 DMN4BIA MI TTMSFAW DMN4BIA MN Cannabinoid receptor 2 (CB2) DMN4BIA MT DTT DMN4BIA MA Modulator DMN4BIA RN BAY 38-7271: a novel highly selective and highly potent cannabinoid receptor agonist for the treatment of traumatic brain injury.CNS Drug Rev.2003 Winter;9(4):343-58. DMN4BIA RU https://www.ncbi.nlm.nih.gov/pubmed/14647528 DMM1SLF DI DMM1SLF DMM1SLF DN KP-736 DMM1SLF MI TTJP4SM DMM1SLF MN Bacterial Penicillin binding protein (Bact PBP) DMM1SLF MT DTT DMM1SLF MA Modulator DMM1SLF RN In vitro antibacterial activity of KP-736, a new cephem antibiotic. Antimicrob Agents Chemother. 1991 Jan;35(1):104-10. DMM1SLF RU https://pubmed.ncbi.nlm.nih.gov/2014964 DMIJ6FX DI DMIJ6FX DMIJ6FX DN KRH-594 DMIJ6FX MI TT8DBY3 DMIJ6FX MN Angiotensin II receptor type-1 (AGTR1) DMIJ6FX MT DTT DMIJ6FX MA Antagonist DMIJ6FX RN Binding of KRH-594, an antagonist of the angiotensin II type 1 receptor, to cloned human and rat angiotensin II receptors. Fundam Clin Pharmacol. 2002 Aug;16(4):317-23. DMIJ6FX RU https://pubmed.ncbi.nlm.nih.gov/12570021 DMZ1SEW DI DMZ1SEW DMZ1SEW DN KRN-2391 DMZ1SEW MI TTEF5MJ DMZ1SEW MN ATP-binding cassette transporter C9 (ABCC9) DMZ1SEW MT DTT DMZ1SEW MA Modulator DMZ1SEW RN Effects of KRN2391 on ionic currents in rabbit femoral arterial myocytes DMZ1SEW RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1572643 DMBU9O4 DI DMBU9O4 DMBU9O4 DN KRP-101 DMBU9O4 MI TTJ584C DMBU9O4 MN Peroxisome proliferator-activated receptor alpha (PPARA) DMBU9O4 MT DTT DMBU9O4 MA Agonist DMBU9O4 RN Identification of a functional peroxisome proliferator-activated receptor (PPAR) response element (PPRE) in the human apolipoprotein A-IV gene. Biochem Pharmacol. 2009 Sep 1;78(5):523-30. DMBU9O4 RU https://pubmed.ncbi.nlm.nih.gov/19433068 DM9VHZC DI DM9VHZC DM9VHZC DN KRP-297 DM9VHZC MI TTJ584C DM9VHZC MN Peroxisome proliferator-activated receptor alpha (PPARA) DM9VHZC MT DTT DM9VHZC MA Modulator DM9VHZC RN KRP-297, MCC-555. Nihon Rinsho. 2001 Nov;59(11):2200-6. DM9VHZC RU https://pubmed.ncbi.nlm.nih.gov/11712408 DM9VHZC DI DM9VHZC DM9VHZC DN KRP-297 DM9VHZC MI TTZMAO3 DM9VHZC MN Peroxisome proliferator-activated receptor gamma (PPAR-gamma) DM9VHZC MT DTT DM9VHZC MA Modulator DM9VHZC RN KRP-297, MCC-555. Nihon Rinsho. 2001 Nov;59(11):2200-6. DM9VHZC RU https://pubmed.ncbi.nlm.nih.gov/11712408 DM5YHJ2 DI DM5YHJ2 DM5YHJ2 DN KW-2170 DM5YHJ2 MI TT0IHXV DM5YHJ2 MN DNA topoisomerase II (TOP2) DM5YHJ2 MT DTT DM5YHJ2 MA Modulator DM5YHJ2 RN KW-2170 (Kyowa Hakko Kogyo). IDrugs. 2002 Oct;5(10):1000-3. DM5YHJ2 RU https://pubmed.ncbi.nlm.nih.gov/12800063 DMSWDKX DI DMSWDKX DMSWDKX DN KW-4490 DMSWDKX MI TTZ97H5 DMSWDKX MN Phosphodiesterase 4A (PDE4A) DMSWDKX MT DTT DMSWDKX MA Inhibitor DMSWDKX RN Pharmacokinetics and metabolism of KW-4490, a selective phosphodiesterase 4 inhibitor: difference in excretion of KW-4490 and acylglucuronide metabolites between rats and cynomolgus monkeys. Xenobiotica. 2008 May;38(5):511-26. DMSWDKX RU https://pubmed.ncbi.nlm.nih.gov/18421624 DMSWDKX DI DMSWDKX DMSWDKX DN KW-4490 DMSWDKX MI TTVIAT9 DMSWDKX MN Phosphodiesterase 4B (PDE4B) DMSWDKX MT DTT DMSWDKX MA Inhibitor DMSWDKX RN Pharmacokinetics and metabolism of KW-4490, a selective phosphodiesterase 4 inhibitor: difference in excretion of KW-4490 and acylglucuronide metabolites between rats and cynomolgus monkeys. Xenobiotica. 2008 May;38(5):511-26. DMSWDKX RU https://pubmed.ncbi.nlm.nih.gov/18421624 DMSWDKX DI DMSWDKX DMSWDKX DN KW-4490 DMSWDKX MI TTSKMI8 DMSWDKX MN Phosphodiesterase 4D (PDE4D) DMSWDKX MT DTT DMSWDKX MA Inhibitor DMSWDKX RN Pharmacokinetics and metabolism of KW-4490, a selective phosphodiesterase 4 inhibitor: difference in excretion of KW-4490 and acylglucuronide metabolites between rats and cynomolgus monkeys. Xenobiotica. 2008 May;38(5):511-26. DMSWDKX RU https://pubmed.ncbi.nlm.nih.gov/18421624 DMLOKXI DI DMLOKXI DMLOKXI DN KW-5139 DMLOKXI MI TT953CX DMLOKXI MN Motilin receptor (MLNR) DMLOKXI MT DTT DMLOKXI MA Modulator DMLOKXI RN Stimulating action of KW-5139 (Leu13-motilin) on gastrointestinal motility in the rabbit. Br J Pharmacol. 1994 Jan;111(1):288-94. DMLOKXI RU https://pubmed.ncbi.nlm.nih.gov/8012708 DMJNSML DI DMJNSML DMJNSML DN KW-7158 DMJNSML MI TT1VOHK DMJNSML MN Potassium channel unspecific (KC) DMJNSML MT DTT DMJNSML MA Agonist DMJNSML RN KW-7158 [(2S)-(+)-3,3,3-trifluoro-2-hydroxy-2-methyl-N-(5,5,10-trioxo-4,10-dihydrothieno[3,2-c][1]benzothiepin-9-yl)propanamide] enhances A-type K+... J Pharmacol Exp Ther. 2004 Jul;310(1):159-68. DMJNSML RU https://pubmed.ncbi.nlm.nih.gov/15010502 DMKSEIY DI DMKSEIY DMKSEIY DN L-158282 DMKSEIY MI TTQVOEI DMKSEIY MN Angiotensin II receptor type-2 (AGTR2) DMKSEIY MT DTT DMKSEIY MA Inhibitor DMKSEIY RN Subtituted phenylthiophene benzoylsulfonamides with potent binding affinity to angiotensin II AT1 and AT2 receptors, Bioorg. Med. Chem. Lett. 4(1):189-194 (1994). DMKSEIY RU http://www.sciencedirect.com/science/article/pii/S0960894X01811458 DMT13ZR DI DMT13ZR DMT13ZR DN L-365260 DMT13ZR MI TTVFO0U DMT13ZR MN Gastrin/cholecystokinin type B receptor (CCKBR) DMT13ZR MT DTT DMT13ZR MA Modulator DMT13ZR RN Pharmacological analysis of CCK(2) receptor ligands using COS-7 and SK-N-MC cells, expressing the human CCK(2) receptor. Regul Pept. 2002 Jan 15;103(1):29-37. DMT13ZR RU https://pubmed.ncbi.nlm.nih.gov/11738246 DM7JZ53 DI DM7JZ53 DM7JZ53 DN L-4-OXALYSINE DM7JZ53 MI TTNRF4L DM7JZ53 MN Histone synthesis (Histone synth) DM7JZ53 MT DTT DM7JZ53 MA Modulator DM7JZ53 RN Immunostimulatory action of L-4-oxalysine counteracts immunosuppression induced by alpha-fetoprotein. Eur J Pharmacol. 1998 Jun 12;351(1):105-11. DM7JZ53 RU https://pubmed.ncbi.nlm.nih.gov/9698211 DMG5VJF DI DMG5VJF DMG5VJF DN L-660771 DMG5VJF MI TTGKOY9 DMG5VJF MN Leukotriene CysLT1 receptor (CYSLTR1) DMG5VJF MT DTT DMG5VJF MA Modulator DMG5VJF RN Pharmacology of the leukotriene antagonist verlukast: the (R)-enantiomer of MK-571. Can J Physiol Pharmacol. 1991 Dec;69(12):1847-54. DMG5VJF RU https://www.ncbi.nlm.nih.gov/pubmed/1666333 DM54I8A DI DM54I8A DM54I8A DN L-696229 DM54I8A MI TT84ETX DM54I8A MN Human immunodeficiency virus Reverse transcriptase (HIV RT) DM54I8A MT DTT DM54I8A MA Inhibitor DM54I8A RN L-696,229 specifically inhibits human immunodeficiency virus type 1 reverse transcriptase and possesses antiviral activity in vitro.. Antimicrob Agents Chemother. 1992 May; 36(5): 1019-1023. DM54I8A RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC188828/ DMW8NOH DI DMW8NOH DMW8NOH DN L-771688 DMW8NOH MI TTNGILX DMW8NOH MN Adrenergic receptor alpha-1A (ADRA1A) DMW8NOH MT DTT DMW8NOH MA Inhibitor DMW8NOH RN Pharmacophore identification of alpha(1A)-adrenoceptor antagonists. Bioorg Med Chem Lett. 2005 Feb 1;15(3):657-64. DMW8NOH RU https://pubmed.ncbi.nlm.nih.gov/15664832 DMSFL76 DI DMSFL76 DMSFL76 DN Labradimil DMSFL76 MI TTGY8IW DMSFL76 MN B2 bradykinin receptor (BDKRB2) DMSFL76 MT DTT DMSFL76 MA Agonist DMSFL76 RN Metabolically stable bradykinin B2 receptor agonists enhance transvascular drug delivery into malignant brain tumors by increasing drug half-life. J Transl Med. 2009 May 13;7:33. DMSFL76 RU https://pubmed.ncbi.nlm.nih.gov/19439100 DM3YABD DI DM3YABD DM3YABD DN LANIQUIDAR DM3YABD MI TTJUXV6 DM3YABD MN Multidrug resistance protein 3 (ABCB4) DM3YABD MT DTT DM3YABD MA Modulator DM3YABD RN Evaluation of [11C]laniquidar as a tracer of P-glycoprotein: radiosynthesis and biodistribution in rats. Nucl Med Biol. 2009 Aug;36(6):643-9. DM3YABD RU https://pubmed.ncbi.nlm.nih.gov/19647170 DM9J6BX DI DM9J6BX DM9J6BX DN LAS-37779 DM9J6BX MI TTZ97H5 DM9J6BX MN Phosphodiesterase 4A (PDE4A) DM9J6BX MT DTT DM9J6BX MA Inhibitor DM9J6BX RN Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800022894) DM9J6BX RU http://adisinsight.springer.com/drugs/800022894 DM9J6BX DI DM9J6BX DM9J6BX DN LAS-37779 DM9J6BX MI TTVIAT9 DM9J6BX MN Phosphodiesterase 4B (PDE4B) DM9J6BX MT DTT DM9J6BX MA Inhibitor DM9J6BX RN Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800022894) DM9J6BX RU http://adisinsight.springer.com/drugs/800022894 DM9J6BX DI DM9J6BX DM9J6BX DN LAS-37779 DM9J6BX MI TTSKMI8 DM9J6BX MN Phosphodiesterase 4D (PDE4D) DM9J6BX MT DTT DM9J6BX MA Inhibitor DM9J6BX RN Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800022894) DM9J6BX RU http://adisinsight.springer.com/drugs/800022894 DMTY5VE DI DMTY5VE DMTY5VE DN Lavoltidine DMTY5VE MI TTQHJ1K DMTY5VE MN Histamine H2 receptor (H2R) DMTY5VE MT DTT DMTY5VE MA Antagonist DMTY5VE RN New and Future Drug Development for Gastroesophageal Reflux Disease. J Neurogastroenterol Motil. 2014 January; 20(1): 6-16. DMTY5VE RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3895610/ DMGQJ2U DI DMGQJ2U DMGQJ2U DN LESOPITRON DIHYDROCHLORIDE DMGQJ2U MI TTSQIFT DMGQJ2U MN 5-HT 1A receptor (HTR1A) DMGQJ2U MT DTT DMGQJ2U MA Agonist DMGQJ2U RN Effect of acute administration of the 5-HT1A receptor ligand, lesopitron, on rat cortical 5-HT and dopamine turnover. Br J Pharmacol. 1994 Oct;113(2):425-30. DMGQJ2U RU https://pubmed.ncbi.nlm.nih.gov/7530571 DMKSY2R DI DMKSY2R DMKSY2R DN Levosemotiadil DMKSY2R MI TT5HONZ DMKSY2R MN Calcium channel unspecific (CaC) DMKSY2R MT DTT DMKSY2R MA Modulator DMKSY2R RN Binding study of semotiadil and levosemotiadil with alpha(1)-acid glycoprotein using high-performance frontal analysis. Anal Biochem. 1999 Oct 1;274(1):27-33. DMKSY2R RU https://pubmed.ncbi.nlm.nih.gov/10527493 DMKSY2R DI DMKSY2R DMKSY2R DN Levosemotiadil DMKSY2R MI TTRK8B9 DMKSY2R MN Sodium channel unspecific (NaC) DMKSY2R MT DTT DMKSY2R MA Modulator DMKSY2R RN Binding study of semotiadil and levosemotiadil with alpha(1)-acid glycoprotein using high-performance frontal analysis. Anal Biochem. 1999 Oct 1;274(1):27-33. DMKSY2R RU https://pubmed.ncbi.nlm.nih.gov/10527493 DMJ3ZT8 DI DMJ3ZT8 DMJ3ZT8 DN Lexacalcitol DMJ3ZT8 MI TTK59TV DMJ3ZT8 MN Vitamin D3 receptor (VDR) DMJ3ZT8 MT DTT DMJ3ZT8 MA Agonist DMJ3ZT8 RN The vitamin D analog, KH1060, is rapidly degraded both in vivo and in vitro via several pathways: principal metabolites generated retain significant biological activity. Endocrinology. 1997 Dec;138(12):5485-96. DMJ3ZT8 RU https://pubmed.ncbi.nlm.nih.gov/9389535 DM8W31H DI DM8W31H DM8W31H DN LG-1550 DM8W31H MI TTOD7B3 DM8W31H MN Retinoic acid receptor (RAR) DM8W31H MT DTT DM8W31H MA Modulator DM8W31H RN US patent application no. 2005,0014,729, Method for the treatment or prevention of dermatological disorders with a cyclooxygenase-2 inhibitor alone and in combination with a dermatological treatment agent and compositions therewith. DM8W31H RU http://www.google.com/patents/US20050014729 DM3R8TI DI DM3R8TI DM3R8TI DN Lifarizine DM3R8TI MI TT5HONZ DM3R8TI MN Calcium channel unspecific (CaC) DM3R8TI MT DTT DM3R8TI MA Blocker DM3R8TI RN The effect of lifarizine (RS-87476), a novel sodium and calcium channel modulator, on ischaemic dopamine depletion in the corpus striatum of the gerbil. Br J Pharmacol. 1993 May;109(1):175-7. DM3R8TI RU https://pubmed.ncbi.nlm.nih.gov/8388296 DMF8B62 DI DMF8B62 DMF8B62 DN Linetastine DMF8B62 MI TT2J34L DMF8B62 MN Arachidonate 5-lipoxygenase (5-LOX) DMF8B62 MT DTT DMF8B62 MA Inhibitor DMF8B62 RN Preview of potential therapeutic applications of leukotriene B4 inhibitors in dermatology. Skin Pharmacol Appl Skin Physiol. 2000 Sep-Oct;13(5):235-45. DMF8B62 RU https://pubmed.ncbi.nlm.nih.gov/10940813 DMF8B62 DI DMF8B62 DMF8B62 DN Linetastine DMF8B62 MI TTYPXQF DMF8B62 MN Protein kinase C beta (PRKCB) DMF8B62 MT DTT DMF8B62 MA Inhibitor DMF8B62 RN Potential new medical therapies for diabetic retinopathy: protein kinase C inhibitors. Am J Ophthalmol. 2002 May;133(5):693-8. DMF8B62 RU https://pubmed.ncbi.nlm.nih.gov/11992868 DM32JL5 DI DM32JL5 DM32JL5 DN Linotroban DM32JL5 MI TT2O84V DM32JL5 MN Thromboxane A2 receptor (TBXA2R) DM32JL5 MT DTT DM32JL5 MA Antagonist DM32JL5 RN Effects of the novel thromboxane (TXA2) receptor antagonist linotroban on inulin and para-aminohippuric acid clearances in the conscious male and female rat. Arzneimittelforschung. 1997 Sep;47(9):1026-30. DM32JL5 RU https://pubmed.ncbi.nlm.nih.gov/9342416 DMS5X94 DI DMS5X94 DMS5X94 DN Lintitript DMS5X94 MI TTCG0AL DMS5X94 MN Cholecystokinin receptor type A (CCKAR) DMS5X94 MT DTT DMS5X94 MA Antagonist DMS5X94 RN A cholecystokinin-1 receptor agonist (CCK-8) mediates increased permeability of brain barriers to leptin. Br J Pharmacol. 2008 Jul;154(5):1009-15. DMS5X94 RU https://pubmed.ncbi.nlm.nih.gov/18587446 DMD39G4 DI DMD39G4 DMD39G4 DN Lintuzumab DMD39G4 MI TTJVYO3 DMD39G4 MN Myeloid cell surface antigen CD33 (CD33) DMD39G4 MT DTT DMD39G4 RN Phase III randomized multicenter study of a humanized anti-CD33 monoclonal antibody, lintuzumab, in combination with chemotherapy, versus chemotherapy alone in patients with refractory or first-relapsed acute myeloid leukemia. J Clin Oncol. 2005 Jun 20;23(18):4110-6. DMD39G4 RU https://pubmed.ncbi.nlm.nih.gov/15961759 DM5ENKG DI DM5ENKG DM5ENKG DN Lirequinil DM5ENKG MI TTPTXIN DM5ENKG MN Translocator protein (TSPO) DM5ENKG MT DTT DM5ENKG MA Agonist DM5ENKG RN Pharmacokinetics and pharmacodynamics of Ro 41-3696, a novel nonbenzodiazepine hypnotic. J Clin Pharmacol. 1995 Aug;35(8):821-9. DM5ENKG RU https://pubmed.ncbi.nlm.nih.gov/8522640 DMGZ3BF DI DMGZ3BF DMGZ3BF DN Lodenosine DMGZ3BF MI TT84ETX DMGZ3BF MN Human immunodeficiency virus Reverse transcriptase (HIV RT) DMGZ3BF MT DTT DMGZ3BF MA Inhibitor DMGZ3BF RN 2 ,3 -Dialdehyde of ATP, ADP, and adenosine inhibit HIV-1 reverse transcriptase and HIV-1 replication. Curr HIV Res. 2014;12(5):347-58. DMGZ3BF RU https://pubmed.ncbi.nlm.nih.gov/25174839 DMW9MOK DI DMW9MOK DMW9MOK DN Lomeguatrib DMW9MOK MI TTX2N1T DMW9MOK MN Transferase unspecific (TF) DMW9MOK MT DTT DMW9MOK MA Inhibitor DMW9MOK RN O6-methylguanine DNA methyltransferase as a promising target for the treatment of temozolomide-resistant gliomas. Cell Death Dis. 2013 Oct 24;4:e876. DMW9MOK RU https://pubmed.ncbi.nlm.nih.gov/24157870 DMCZI62 DI DMCZI62 DMCZI62 DN LORECLEZOLE DMCZI62 MI TTEX6LM DMCZI62 MN GABA(A) receptor gamma-3 (GABRG3) DMCZI62 MT DTT DMCZI62 MA Modulator DMCZI62 RN Direct activation of GABAA receptors by loreclezole, an anticonvulsant drug with selectivity for the beta-subunit. Neuropharmacology. 1996;35(12):1753-60. DMCZI62 RU https://pubmed.ncbi.nlm.nih.gov/9076754 DMM843E DI DMM843E DMM843E DN LOSOXANTRONE DMM843E MI TT0IHXV DMM843E MN DNA topoisomerase II (TOP2) DMM843E MT DTT DMM843E MA Modulator DMM843E RN A structure-based 3D-QSAR study of anthrapyrazole analogues of the anticancer agents losoxantrone and piroxantrone. J Chem Inf Model. 2006 Jul-Aug;46(4):1827-35. DMM843E RU https://www.ncbi.nlm.nih.gov/pubmed/16859314 DMD16VS DI DMD16VS DMD16VS DN Loviride DMD16VS MI TT84ETX DMD16VS MN Human immunodeficiency virus Reverse transcriptase (HIV RT) DMD16VS MT DTT DMD16VS MA Inhibitor DMD16VS RN Nucleoside reverse transcriptase inhibitor resistance mutations associated with first-line stavudine-containing antiretroviral therapy: programmatic implications for countries phasing out stavudine. J Infect Dis. 2013 Jun 15;207 Suppl 2:S70-7. DMD16VS RU https://pubmed.ncbi.nlm.nih.gov/23687292 DM6G0PN DI DM6G0PN DM6G0PN DN LTB 019 DM6G0PN MI TTN53ZF DM6G0PN MN Leukotriene B4 receptor 1 (LTB4R) DM6G0PN MT DTT DM6G0PN MA Antagonist DM6G0PN RN Effect of the oral leukotriene B4 receptor antagonist LTB019 on inflammatory sputum markers in patients with chronic obstructive pulmonary disease. Pulm Pharmacol Ther. 2008;21(2):409-17. DM6G0PN RU https://pubmed.ncbi.nlm.nih.gov/18063399 DMQ7A35 DI DMQ7A35 DMQ7A35 DN Lu-35138 DMQ7A35 MI TTE0A2F DMQ7A35 MN Dopamine D4 receptor (D4R) DMQ7A35 MT DTT DMQ7A35 MA Antagonist DMQ7A35 RN Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800014237) DMQ7A35 RU http://adisinsight.springer.com/drugs/800014237 DMYR2U3 DI DMYR2U3 DMYR2U3 DN Lurosetron DMYR2U3 MI TTNXLKE DMYR2U3 MN 5-HT 3 receptor (5HT3R) DMYR2U3 MT DTT DMYR2U3 MA Modulator DMYR2U3 RN US patent application no. 7,932,267, Use of α-glucosidase inhibitors to treat alphavirus infections. DMYR2U3 RU http://www.google.is/Patents/US7932267 DMF1RTW DI DMF1RTW DMF1RTW DN Lurtotecan DMF1RTW MI DTI7UX6 DMF1RTW MN Breast cancer resistance protein (ABCG2) DMF1RTW MT DTP DMF1RTW MA Substrate DMF1RTW RN A prediction model of substrates and non-substrates of breast cancer resistance protein (BCRP) developed by GA-CG-SVM method. Comput Biol Med. 2011 Nov;41(11):1006-13. DMF1RTW RU https://doi.org/10.1016/j.compbiomed.2011.08.009 DMF1RTW DI DMF1RTW DMF1RTW DN Lurtotecan DMF1RTW MI TTGTQHC DMF1RTW MN DNA topoisomerase I (TOP1) DMF1RTW MT DTT DMF1RTW MA Inhibitor DMF1RTW RN Phase I and pharmacokinetic study of a low-clearance, unilamellar liposomal formulation of lurtotecan, a topoisomerase 1 inhibitor, in patients with advanced leukemia. Cancer. 2004 Apr 1;100(7):1449-58. DMF1RTW RU https://pubmed.ncbi.nlm.nih.gov/15042679 DMWB7DO DI DMWB7DO DMWB7DO DN LY-223982 DMWB7DO MI TTN53ZF DMWB7DO MN Leukotriene B4 receptor 1 (LTB4R) DMWB7DO MT DTT DMWB7DO MA Modulator DMWB7DO RN Specific inhibition of leukotriene B4-induced neutrophil activation by LY223982. J Pharmacol Exp Ther. 1992 Dec;263(3):1009-14. DMWB7DO RU https://pubmed.ncbi.nlm.nih.gov/1335049 DMTS1X5 DI DMTS1X5 DMTS1X5 DN LY-2300559 DMTS1X5 MI TTGKOY9 DMTS1X5 MN Leukotriene CysLT1 receptor (CYSLTR1) DMTS1X5 MT DTT DMTS1X5 MA Modulator DMTS1X5 RN Annual Reports in Medicinal Chemistry. Elsevier (ISBN: 9780123964922). 2012, p78 DMTS1X5 RU https://books.google.com.hk/books?id=y7GH165YoOsC&pg=PA78&lpg=PA78&dq=LY-2300559++mGluR2&source=bl&ots=oPRCoyeFUF&sig=mBJoAwlOyt44UDkkH77x_aHKhbE&hl=zh-CN&sa=X&ved=0CBoQ6AEwAGoVChMIup7Nm-HwyAIVgRmmCh2Dpgc7#v=onepage&q=LY-2300559%20%20mGluR2&f=false DMTS1X5 DI DMTS1X5 DMTS1X5 DN LY-2300559 DMTS1X5 MI TTXJ47W DMTS1X5 MN Metabotropic glutamate receptor 2 (mGluR2) DMTS1X5 MT DTT DMTS1X5 MA Modulator DMTS1X5 RN Annual Reports in Medicinal Chemistry. Elsevier (ISBN: 9780123964922). 2012, p78 DMTS1X5 RU https://books.google.com.hk/books?id=y7GH165YoOsC&pg=PA78&lpg=PA78&dq=LY-2300559++mGluR2&source=bl&ots=oPRCoyeFUF&sig=mBJoAwlOyt44UDkkH77x_aHKhbE&hl=zh-CN&sa=X&ved=0CBoQ6AEwAGoVChMIup7Nm-HwyAIVgRmmCh2Dpgc7#v=onepage&q=LY-2300559%20%20mGluR2&f=false DMGE9OA DI DMGE9OA DMGE9OA DN LY-2523199 DMGE9OA MI TTN7BL9 DMGE9OA MN Corticosteroid 11-beta-dehydrogenase 1 (HSD11B1) DMGE9OA MT DTT DMGE9OA MA Inhibitor DMGE9OA RN Repurposing Diabetes Drugs for Brain Insulin Resistance in Alzheimer Disease. before print June 15, 2014. DMGE9OA RU http://diabetes.diabetesjournals.org/content/63/7/2253.full DM03FHA DI DM03FHA DM03FHA DN LY293111 DM03FHA MI TTN53ZF DM03FHA MN Leukotriene B4 receptor 1 (LTB4R) DM03FHA MT DTT DM03FHA MA Antagonist DM03FHA RN The Role of PPARgamma Receptors and Leukotriene B(4) Receptors in Mediating the Effects of LY293111 in Pancreatic Cancer. PPAR Res. 2008;2008:827096. DM03FHA RU https://pubmed.ncbi.nlm.nih.gov/19190780 DMIS7DW DI DMIS7DW DMIS7DW DN LY-307161 DMIS7DW MI TTVIMDE DMIS7DW MN Glucagon-like peptide 1 receptor (GLP1R) DMIS7DW MT DTT DMIS7DW MA Modulator DMIS7DW RN Gateways to clinical trials. Methods Find Exp Clin Pharmacol. 2003 Sep;25(7):565-97. DMIS7DW RU https://pubmed.ncbi.nlm.nih.gov/14571286 DM08BIZ DI DM08BIZ DM08BIZ DN LY354740 DM08BIZ MI TTXJ47W DM08BIZ MN Metabotropic glutamate receptor 2 (mGluR2) DM08BIZ MT DTT DM08BIZ MA Agonist DM08BIZ RN Characterization of [(3)H]-LY354740 binding to rat mGlu2 and mGlu3 receptors expressed in CHO cells using semliki forest virus vectors. Neuropharmacology. 2000 Jul 24;39(10):1700-6. DM08BIZ RU https://pubmed.ncbi.nlm.nih.gov/10884552 DM08BIZ DI DM08BIZ DM08BIZ DN LY354740 DM08BIZ MI TT8A9EF DM08BIZ MN Metabotropic glutamate receptor 3 (mGluR3) DM08BIZ MT DTT DM08BIZ MA Agonist DM08BIZ RN Mutagenesis and molecular modeling of the orthosteric binding site of the mGlu2 receptor determining interactions of the group II receptor antagonist (3)H-HYDIA. ChemMedChem. 2009 Jul;4(7):1086-94. DM08BIZ RU https://pubmed.ncbi.nlm.nih.gov/19402024 DMQ1LWU DI DMQ1LWU DMQ1LWU DN M-100240 DMQ1LWU MI TTL69WB DMQ1LWU MN Angiotensin-converting enzyme (ACE) DMQ1LWU MT DTT DMQ1LWU MA Modulator DMQ1LWU RN Effects of MDL 100,240, a dual inhibitor of angiotensin-converting enzyme and neutral endopeptidase on the vasopressor response to exogenous angiot... J Cardiovasc Pharmacol. 1998 Mar;31(3):408-17. DMQ1LWU RU https://www.ncbi.nlm.nih.gov/pubmed/9514186 DMQ1LWU DI DMQ1LWU DMQ1LWU DN M-100240 DMQ1LWU MI TT5TKPM DMQ1LWU MN Neutral endopeptidase (MME) DMQ1LWU MT DTT DMQ1LWU MA Modulator DMQ1LWU RN Effects of MDL 100,240, a dual inhibitor of angiotensin-converting enzyme and neutral endopeptidase on the vasopressor response to exogenous angiot... J Cardiovasc Pharmacol. 1998 Mar;31(3):408-17. DMQ1LWU RU https://www.ncbi.nlm.nih.gov/pubmed/9514186 DMRN7GC DI DMRN7GC DMRN7GC DN Manifaxine DMRN7GC MI TTVBI8W DMRN7GC MN Dopamine transporter (DAT) DMRN7GC MT DTT DMRN7GC MA Modulator DMRN7GC RN Pharmacogenetics and obesity: common gene variants influence weight loss response of the norepinephrine/dopamine transporter inhibitor GW320659 in obese subjects. Pharmacogenet Genomics. 2005 Dec;15(12):883-9. DMRN7GC RU https://pubmed.ncbi.nlm.nih.gov/16272960 DMRN7GC DI DMRN7GC DMRN7GC DN Manifaxine DMRN7GC MI TTAWNKZ DMRN7GC MN Norepinephrine transporter (NET) DMRN7GC MT DTT DMRN7GC MA Modulator DMRN7GC RN Pharmacogenetics and obesity: common gene variants influence weight loss response of the norepinephrine/dopamine transporter inhibitor GW320659 in obese subjects. Pharmacogenet Genomics. 2005 Dec;15(12):883-9. DMRN7GC RU https://pubmed.ncbi.nlm.nih.gov/16272960 DM1LM7D DI DM1LM7D DM1LM7D DN Mannose phosphate DM1LM7D MI TTR9XHZ DM1LM7D MN Transforming growth factor beta 1 (TGFB1) DM1LM7D MT DTT DM1LM7D MA Modulator DM1LM7D RN The mannose-6-phosphate analogue, PXS64, inhibits fibrosis via TGF-beta1 pathway in human lung fibroblasts. Immunol Lett. 2015 Jun;165(2):90-101. DM1LM7D RU https://pubmed.ncbi.nlm.nih.gov/25929803 DMRHYAU DI DMRHYAU DMRHYAU DN MAZAPERTINE DMRHYAU MI TTSQIFT DMRHYAU MN 5-HT 1A receptor (HTR1A) DMRHYAU MT DTT DMRHYAU MA Inhibitor DMRHYAU RN A new arylpiperazine antipsychotic with high D2/D3/5-HT1A/alpha 1A-adrenergic affinity and a low potential for extrapyramidal effects. J Med Chem. 1994 Apr 15;37(8):1060-2. DMRHYAU RU https://pubmed.ncbi.nlm.nih.gov/7909336 DMRHYAU DI DMRHYAU DMRHYAU DN MAZAPERTINE DMRHYAU MI TTJQOD7 DMRHYAU MN 5-HT 2A receptor (HTR2A) DMRHYAU MT DTT DMRHYAU MA Inhibitor DMRHYAU RN A new arylpiperazine antipsychotic with high D2/D3/5-HT1A/alpha 1A-adrenergic affinity and a low potential for extrapyramidal effects. J Med Chem. 1994 Apr 15;37(8):1060-2. DMRHYAU RU https://pubmed.ncbi.nlm.nih.gov/7909336 DMRHYAU DI DMRHYAU DMRHYAU DN MAZAPERTINE DMRHYAU MI TTNGILX DMRHYAU MN Adrenergic receptor alpha-1A (ADRA1A) DMRHYAU MT DTT DMRHYAU MA Inhibitor DMRHYAU RN A new arylpiperazine antipsychotic with high D2/D3/5-HT1A/alpha 1A-adrenergic affinity and a low potential for extrapyramidal effects. J Med Chem. 1994 Apr 15;37(8):1060-2. DMRHYAU RU https://pubmed.ncbi.nlm.nih.gov/7909336 DMRHYAU DI DMRHYAU DMRHYAU DN MAZAPERTINE DMRHYAU MI TTBRKXS DMRHYAU MN Adrenergic receptor alpha-1B (ADRA1B) DMRHYAU MT DTT DMRHYAU MA Inhibitor DMRHYAU RN A new arylpiperazine antipsychotic with high D2/D3/5-HT1A/alpha 1A-adrenergic affinity and a low potential for extrapyramidal effects. J Med Chem. 1994 Apr 15;37(8):1060-2. DMRHYAU RU https://pubmed.ncbi.nlm.nih.gov/7909336 DMRHYAU DI DMRHYAU DMRHYAU DN MAZAPERTINE DMRHYAU MI TT34BHT DMRHYAU MN Adrenergic receptor alpha-1D (ADRA1D) DMRHYAU MT DTT DMRHYAU MA Inhibitor DMRHYAU RN A new arylpiperazine antipsychotic with high D2/D3/5-HT1A/alpha 1A-adrenergic affinity and a low potential for extrapyramidal effects. J Med Chem. 1994 Apr 15;37(8):1060-2. DMRHYAU RU https://pubmed.ncbi.nlm.nih.gov/7909336 DMRHYAU DI DMRHYAU DMRHYAU DN MAZAPERTINE DMRHYAU MI TTWG9A4 DMRHYAU MN Adrenergic receptor alpha-2A (ADRA2A) DMRHYAU MT DTT DMRHYAU MA Inhibitor DMRHYAU RN A new arylpiperazine antipsychotic with high D2/D3/5-HT1A/alpha 1A-adrenergic affinity and a low potential for extrapyramidal effects. J Med Chem. 1994 Apr 15;37(8):1060-2. DMRHYAU RU https://pubmed.ncbi.nlm.nih.gov/7909336 DMRHYAU DI DMRHYAU DMRHYAU DN MAZAPERTINE DMRHYAU MI TTWM4TY DMRHYAU MN Adrenergic receptor alpha-2B (ADRA2B) DMRHYAU MT DTT DMRHYAU MA Inhibitor DMRHYAU RN A new arylpiperazine antipsychotic with high D2/D3/5-HT1A/alpha 1A-adrenergic affinity and a low potential for extrapyramidal effects. J Med Chem. 1994 Apr 15;37(8):1060-2. DMRHYAU RU https://pubmed.ncbi.nlm.nih.gov/7909336 DMRHYAU DI DMRHYAU DMRHYAU DN MAZAPERTINE DMRHYAU MI TT2NUT5 DMRHYAU MN Adrenergic receptor alpha-2C (ADRA2C) DMRHYAU MT DTT DMRHYAU MA Inhibitor DMRHYAU RN A new arylpiperazine antipsychotic with high D2/D3/5-HT1A/alpha 1A-adrenergic affinity and a low potential for extrapyramidal effects. J Med Chem. 1994 Apr 15;37(8):1060-2. DMRHYAU RU https://pubmed.ncbi.nlm.nih.gov/7909336 DMRHYAU DI DMRHYAU DMRHYAU DN MAZAPERTINE DMRHYAU MI TTEX248 DMRHYAU MN Dopamine D2 receptor (D2R) DMRHYAU MT DTT DMRHYAU MA Inhibitor DMRHYAU RN A new arylpiperazine antipsychotic with high D2/D3/5-HT1A/alpha 1A-adrenergic affinity and a low potential for extrapyramidal effects. J Med Chem. 1994 Apr 15;37(8):1060-2. DMRHYAU RU https://pubmed.ncbi.nlm.nih.gov/7909336 DMRHYAU DI DMRHYAU DMRHYAU DN MAZAPERTINE DMRHYAU MI TT4C8EA DMRHYAU MN Dopamine D3 receptor (D3R) DMRHYAU MT DTT DMRHYAU MA Inhibitor DMRHYAU RN A new arylpiperazine antipsychotic with high D2/D3/5-HT1A/alpha 1A-adrenergic affinity and a low potential for extrapyramidal effects. J Med Chem. 1994 Apr 15;37(8):1060-2. DMRHYAU RU https://pubmed.ncbi.nlm.nih.gov/7909336 DMIG5W8 DI DMIG5W8 DMIG5W8 DN MCPP DMIG5W8 MI TTWJBZ5 DMIG5W8 MN 5-HT 2C receptor (HTR2C) DMIG5W8 MT DTT DMIG5W8 MA Agonist DMIG5W8 RN mCPP-induced hyperactivity in 5-HT2C receptor mutant mice is mediated by activation of multiple 5-HT receptor subtypes. Neuropharmacology. 2004 Apr;46(5):663-71. DMIG5W8 RU https://pubmed.ncbi.nlm.nih.gov/14996544 DMIG5W8 DI DMIG5W8 DMIG5W8 DN MCPP DMIG5W8 MI DECB0K3 DMIG5W8 MN Cytochrome P450 2D6 (CYP2D6) DMIG5W8 MT DME DMIG5W8 MA Metabolism DMIG5W8 RN Proof of a 1-(3-chlorophenyl)piperazine (mCPP) intake: use as adulterant of cocaine resulting in drug-drug interactions? J Chromatogr B Analyt Technol Biomed Life Sci. 2007 Aug 15;855(2):127-33. DMIG5W8 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=17574934 DMKEYSX DI DMKEYSX DMKEYSX DN MDL 101,731 DMKEYSX MI TTBWDI0 DMKEYSX MN Ribonucleoside-diphosphate reductase M2 (RRM2) DMKEYSX MT DTT DMKEYSX MA Modulator DMKEYSX RN Tezacitabine Hoechst Marion Roussel.Curr Opin Investig Drugs.2000 Sep;1(1):135-40. DMKEYSX RU https://www.ncbi.nlm.nih.gov/pubmed/11249589 DM9ZEGT DI DM9ZEGT DM9ZEGT DN MDX-070 DM9ZEGT MI TT9G4N0 DM9ZEGT MN Glutamate carboxypeptidase II (GCPII) DM9ZEGT MT DTT DM9ZEGT RN Nanoparticles for Improving Cancer Diagnosis. Mater Sci Eng R Rep. 2013 March; 74(3): 35-69. DM9ZEGT RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3779646/ DM3HIQY DI DM3HIQY DM3HIQY DN Melanoma vaccine (ALVAC) DM3HIQY MI TTE5ITK DM3HIQY MN Cancer/testis antigen 1 (NY-ESO-1) DM3HIQY MT DTT DM3HIQY RN Preclinical qualification of a new multi-antigen candidate vaccine for metastatic melanoma. J Immunother. 2010 Oct;33(8):743-58. DM3HIQY RU https://pubmed.ncbi.nlm.nih.gov/20842062 DM3HIQY DI DM3HIQY DM3HIQY DN Melanoma vaccine (ALVAC) DM3HIQY MI TT362RB DM3HIQY MN MART-1 melanoma antigen (MLANA) DM3HIQY MT DTT DM3HIQY RN Preclinical qualification of a new multi-antigen candidate vaccine for metastatic melanoma. J Immunother. 2010 Oct;33(8):743-58. DM3HIQY RU https://pubmed.ncbi.nlm.nih.gov/20842062 DM3HIQY DI DM3HIQY DM3HIQY DN Melanoma vaccine (ALVAC) DM3HIQY MI TT8MK59 DM3HIQY MN Melanocytes lineage-specific antigen GP100 (PMEL) DM3HIQY MT DTT DM3HIQY RN Preclinical qualification of a new multi-antigen candidate vaccine for metastatic melanoma. J Immunother. 2010 Oct;33(8):743-58. DM3HIQY RU https://pubmed.ncbi.nlm.nih.gov/20842062 DM3HIQY DI DM3HIQY DM3HIQY DN Melanoma vaccine (ALVAC) DM3HIQY MI TT63M7Q DM3HIQY MN Melanoma-associated antigen 1 (MAGEA1) DM3HIQY MT DTT DM3HIQY RN Preclinical qualification of a new multi-antigen candidate vaccine for metastatic melanoma. J Immunother. 2010 Oct;33(8):743-58. DM3HIQY RU https://pubmed.ncbi.nlm.nih.gov/20842062 DM3HIQY DI DM3HIQY DM3HIQY DN Melanoma vaccine (ALVAC) DM3HIQY MI TTWSKHD DM3HIQY MN Melanoma-associated antigen 3 (MAGEA3) DM3HIQY MT DTT DM3HIQY RN Preclinical qualification of a new multi-antigen candidate vaccine for metastatic melanoma. J Immunother. 2010 Oct;33(8):743-58. DM3HIQY RU https://pubmed.ncbi.nlm.nih.gov/20842062 DM2DK4A DI DM2DK4A DM2DK4A DN Mequitamium iodide DM2DK4A MI TTTIBOJ DM2DK4A MN Histamine H1 receptor (H1R) DM2DK4A MT DTT DM2DK4A MA Modulator DM2DK4A RN High-affinity binding of mequitamium iodide (LG 30435) to muscarinic and histamine H1 receptors. Eur J Pharmacol. 1990 Jul 17;182(3):413-20. DM2DK4A RU https://pubmed.ncbi.nlm.nih.gov/2226618 DMMZ4E9 DI DMMZ4E9 DMMZ4E9 DN Merbarone DMMZ4E9 MI TT0IHXV DMMZ4E9 MN DNA topoisomerase II (TOP2) DMMZ4E9 MT DTT DMMZ4E9 MA Modulator DMMZ4E9 RN The DNA topoisomerase II catalytic inhibitor merbarone is genotoxic and induces endoreduplication. Mutat Res. 2012 Oct-Nov;738-739:45-51. DMMZ4E9 RU https://pubmed.ncbi.nlm.nih.gov/22921906 DM90SHY DI DM90SHY DM90SHY DN METIAPRIL DM90SHY MI TTL69WB DM90SHY MN Angiotensin-converting enzyme (ACE) DM90SHY MT DTT DM90SHY MA Inhibitor DM90SHY RN The clinical efficacy of the first Russian angiotensin-converting enzyme inhibitor methiopril in patients with heart failure. Klin Med (Mosk). 1995;73(3):49-51. DM90SHY RU https://pubmed.ncbi.nlm.nih.gov/8577109 DMJLNUD DI DMJLNUD DMJLNUD DN MILACAINIDE TARTRATE DMJLNUD MI TTKNWZ4 DMJLNUD MN Thromboxane-A synthase (TBXAS1) DMJLNUD MT DTT DMJLNUD MA Antagonist DMJLNUD RN Effects of the new class I antiarrhythmic agent Ro 22-9194, (2R)-2-amino-N-(2,6-dimethylphenyl)-N-[3-(3-pyridyl)propyl]propionamide D-tartrate, on ischemia- and reperfusion-induced arrhythmias in dogs: involvement of thromboxane A2 synthase inhibitory activity. J Pharmacol Exp Ther. 1996 Nov;279(2):877-83. DMJLNUD RU https://pubmed.ncbi.nlm.nih.gov/8930195 DMTX97J DI DMTX97J DMTX97J DN MILFASARTAN DMTX97J MI TT8DBY3 DMTX97J MN Angiotensin II receptor type-1 (AGTR1) DMTX97J MT DTT DMTX97J MA Antagonist DMTX97J RN Dual action molecules: bioassays of combined novel antioxidants and angiotensin II receptor antagonists. Eur J Pharmacol. 2012 Nov 15;695(1-3):96-103. DMTX97J RU https://pubmed.ncbi.nlm.nih.gov/22975712 DMF1IH5 DI DMF1IH5 DMF1IH5 DN Milveterol DMF1IH5 MI TT2CJVK DMF1IH5 MN Adrenergic receptor beta-2 (ADRB2) DMF1IH5 MT DTT DMF1IH5 MA Agonist DMF1IH5 RN Clinical pipeline report, company report or official report of GlaxoSmithKline (2009). DMF1IH5 RU http://www.gsk.com/investors/product_pipeline/docs/gsk-pipeline-feb09.pdf DMP8CVD DI DMP8CVD DMP8CVD DN Milveterol+Fluticasone DMP8CVD MI TT2CJVK DMP8CVD MN Adrenergic receptor beta-2 (ADRB2) DMP8CVD MT DTT DMP8CVD MA Agonist DMP8CVD RN Emerging drugs in chronic obstructive pulmonary disease. Expert Opin Emerg Drugs. 2009 Mar;14(1):181-94. DMP8CVD RU https://pubmed.ncbi.nlm.nih.gov/19265487 DMVF2R1 DI DMVF2R1 DMVF2R1 DN Minopafant DMVF2R1 MI TTQL5VC DMVF2R1 MN Platelet-activating factor receptor (PTAFR) DMVF2R1 MT DTT DMVF2R1 MA Antagonist DMVF2R1 RN Formation of spherical micelles composed of the novel platelet activating factor receptor antagonist, E5880. Pharm Dev Technol. 2005;10(1):11-6. DMVF2R1 RU https://pubmed.ncbi.nlm.nih.gov/15776809 DMT6IUR DI DMT6IUR DMT6IUR DN MIRFENTANIL HYDROCHLORIDE DMT6IUR MI TTKWM86 DMT6IUR MN Opioid receptor mu (MOP) DMT6IUR MT DTT DMT6IUR MA Agonist DMT6IUR RN Mirfentanil: pharmacological profile of a novel fentanyl derivative with opioid and nonopioid effects. J Pharmacol Exp Ther. 1991 Aug;258(2):502-10. DMT6IUR RU https://pubmed.ncbi.nlm.nih.gov/1650830 DMW59FE DI DMW59FE DMW59FE DN Mitonafide DMW59FE MI TT0IHXV DMW59FE MN DNA topoisomerase II (TOP2) DMW59FE MT DTT DMW59FE MA Modulator DMW59FE RN Effect of mitonafide analogs on topoisomerase II of Leishmania chagasi. Antimicrob Agents Chemother. 1996 Mar;40(3):706-9. DMW59FE RU https://pubmed.ncbi.nlm.nih.gov/8851597 DMCAKPG DI DMCAKPG DMCAKPG DN MK-287 DMCAKPG MI TTQL5VC DMCAKPG MN Platelet-activating factor receptor (PTAFR) DMCAKPG MT DTT DMCAKPG MA Antagonist DMCAKPG RN MK 287: a potent, specific, and orally active receptor antagonist of platelet-activating factor. J Lipid Mediat. 1993 Jun;7(2):115-34. DMCAKPG RU https://pubmed.ncbi.nlm.nih.gov/8400114 DM48ELZ DI DM48ELZ DM48ELZ DN MK-386 DM48ELZ MI TTTU72V DM48ELZ MN Steroid 5-alpha-reductase 1 (SRD5A1) DM48ELZ MT DTT DM48ELZ MA Inhibitor DM48ELZ RN Synthesis of 8-chloro-benzo[c]quinolizin-3-ones as potent and selective inhibitors of human steroid 5alpha-reductase 1. Bioorg Med Chem Lett. 2000 Feb 21;10(4):353-6. DM48ELZ RU https://pubmed.ncbi.nlm.nih.gov/10714498 DMVEGW6 DI DMVEGW6 DMVEGW6 DN MK-499 DMVEGW6 MI TTQ6VDM DMVEGW6 MN Voltage-gated potassium channel Kv11.1 (KCNH2) DMVEGW6 MT DTT DMVEGW6 MA Inhibitor DMVEGW6 RN Characterization of HERG potassium channel inhibition using CoMSiA 3D QSAR and homology modeling approaches. Bioorg Med Chem Lett. 2003 May 19;13(10):1829-35. DMVEGW6 RU https://pubmed.ncbi.nlm.nih.gov/12729675 DMVXTZG DI DMVXTZG DMVXTZG DN MK-591 DMVXTZG MI TT2J34L DMVXTZG MN Arachidonate 5-lipoxygenase (5-LOX) DMVXTZG MT DTT DMVXTZG MA Inhibitor DMVXTZG RN Antileukotriene therapy for asthma. Am J Health Syst Pharm. 1996 Dec 1;53(23):2821-30; quiz 2877-8. DMVXTZG RU https://pubmed.ncbi.nlm.nih.gov/8957342 DMBJLZG DI DMBJLZG DMBJLZG DN MK-852 DMBJLZG MI TT38RM1 DMBJLZG MN Glycoprotein IIb/IIIa receptor (GPIIb/IIIa) DMBJLZG MT DTT DMBJLZG MA Modulator DMBJLZG RN Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41. DMBJLZG RU https://www.ncbi.nlm.nih.gov/pubmed/15950434 DMT0O7H DI DMT0O7H DMT0O7H DN MK-886 DMT0O7H MI TT2J34L DMT0O7H MN Arachidonate 5-lipoxygenase (5-LOX) DMT0O7H MT DTT DMT0O7H MA Modulator DMT0O7H RN Inhibitory effects of MK-886 on arachidonic acid metabolism in human phagocytes. Br J Pharmacol. 1990 May;100(1):15-20. DMT0O7H RU https://www.ncbi.nlm.nih.gov/pubmed/2164857 DMMNUZC DI DMMNUZC DMMNUZC DN MK-912 DMMNUZC MI TT2NUT5 DMMNUZC MN Adrenergic receptor alpha-2C (ADRA2C) DMMNUZC MT DTT DMMNUZC MA Antagonist DMMNUZC RN Silent alpha(2C)-adrenergic receptors enable cold-induced vasoconstriction in cutaneous arteries. Am J Physiol Heart Circ Physiol. 2000 Apr;278(4):H1075-83. DMMNUZC RU https://pubmed.ncbi.nlm.nih.gov/10749700 DMOZUPB DI DMOZUPB DMOZUPB DN MK-944a DMOZUPB MI TT5FNQT DMOZUPB MN Human immunodeficiency virus Protease (HIV PR) DMOZUPB MT DTT DMOZUPB MA Inhibitor DMOZUPB RN Identification of MK-944a: a second clinical candidate from the hydroxylaminepentanamide isostere series of HIV protease inhibitors. J Med Chem. 2000 Sep 7;43(18):3386-99. DMOZUPB RU https://pubmed.ncbi.nlm.nih.gov/10978186 DMRA3EZ DI DMRA3EZ DMRA3EZ DN MLN3897 DMRA3EZ MI TTC24WT DMRA3EZ MN C-C chemokine receptor type 1 (CCR1) DMRA3EZ MT DTT DMRA3EZ MA Antagonist DMRA3EZ RN Emerging drugs for rheumatoid arthritis. Expert Opin Emerg Drugs. 2008 Mar;13(1):175-96. DMRA3EZ RU https://pubmed.ncbi.nlm.nih.gov/18321156 DMTWLG8 DI DMTWLG8 DMTWLG8 DN MLN-977 DMTWLG8 MI TT2J34L DMTWLG8 MN Arachidonate 5-lipoxygenase (5-LOX) DMTWLG8 MT DTT DMTWLG8 MA Inhibitor DMTWLG8 RN Inflammation, Cancer and Oxidative Lipoxygenase Activity are Intimately Linked. Cancers (Basel) 2014 September; 6(3): 1500-1521. DMTWLG8 RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4190552/ DMLG7QB DI DMLG7QB DMLG7QB DN Mozenavir DMLG7QB MI TT5FNQT DMLG7QB MN Human immunodeficiency virus Protease (HIV PR) DMLG7QB MT DTT DMLG7QB MA Inhibitor DMLG7QB RN Improved cyclic urea inhibitors of the HIV-1 protease: synthesis, potency, resistance profile, human pharmacokinetics and X-ray crystal structure of DMP 450. Chem Biol. 1996 Apr;3(4):301-14. DMLG7QB RU https://pubmed.ncbi.nlm.nih.gov/8807858 DMMKHGN DI DMMKHGN DMMKHGN DN MP-435 DMMKHGN MI TTKANGO DMMKHGN MN Complement C5 (CO5) DMMKHGN MT DTT DMMKHGN MA Antagonist DMMKHGN RN Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800027730) DMMKHGN RU http://adisinsight.springer.com/drugs/800027730 DMKF3TD DI DMKF3TD DMKF3TD DN Nafagrel DMKF3TD MI TT2GVH5 DMKF3TD MN Isomerase unspecific (IsoM) DMKF3TD MT DTT DMKF3TD MA Modulator DMKF3TD RN FMLP actions and its binding sites in isolated human coronary arteries. J Mol Cell Cardiol. 1997 Mar;29(3):881-94. DMKF3TD RU https://pubmed.ncbi.nlm.nih.gov/9152849 DMF9Y57 DI DMF9Y57 DMF9Y57 DN Napitane mesilate DMF9Y57 MI TTAWNKZ DMF9Y57 MN Norepinephrine transporter (NET) DMF9Y57 MT DTT DMF9Y57 MA Modulator DMF9Y57 RN Enhancing central noradrenergic function in depression: is there still a place for a new antidepressant DMF9Y57 RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2426812 DM8L4Z0 DI DM8L4Z0 DM8L4Z0 DN Napsagatran DM8L4Z0 MI TT6L509 DM8L4Z0 MN Coagulation factor IIa (F2) DM8L4Z0 MT DTT DM8L4Z0 MA Inhibitor DM8L4Z0 RN Effects of napsagatran (Ro 46-6240), a new synthetic thrombin inhibitor and of heparin in a canine model of coronary artery thrombosis: comparison with an ex vivo annular perfusion chamber model. J Pharmacol Exp Ther. 1996 Apr;277(1):71-8. DM8L4Z0 RU https://pubmed.ncbi.nlm.nih.gov/8613969 DM8BHL6 DI DM8BHL6 DM8BHL6 DN Naronapride DM8BHL6 MI TT07C3Y DM8BHL6 MN 5-HT 4 receptor (HTR4) DM8BHL6 MT DTT DM8BHL6 MA Agonist DM8BHL6 RN Systematic review: cardiovascular safety profile of 5-HT(4) agonists developed for gastrointestinal disorders. Aliment Pharmacol Ther. 2012 Apr;35(7):745-67. DM8BHL6 RU https://pubmed.ncbi.nlm.nih.gov/22356640 DM9K2IO DI DM9K2IO DM9K2IO DN Naxagolide DM9K2IO MI TTEX248 DM9K2IO MN Dopamine D2 receptor (D2R) DM9K2IO MT DTT DM9K2IO MA Modulator DM9K2IO RN Comparison between the pharmacology of dopamine receptors mediating the inhibition of cell firing in rat brain slices through the substantia nigra pars compacta and ventral tegmental area. Br J Pharmacol. 1994 Jul;112(3):873-80. DM9K2IO RU https://pubmed.ncbi.nlm.nih.gov/7921615 DMGVYXB DI DMGVYXB DMGVYXB DN NB-506 DMGVYXB MI DTI7UX6 DMGVYXB MN Breast cancer resistance protein (ABCG2) DMGVYXB MT DTP DMGVYXB MA Substrate DMGVYXB RN Pharmacogenomic importance of ABCG2. Pharmacogenomics. 2008 Aug;9(8):1005-9. DMGVYXB RU https://doi.org/10.2217/14622416.9.8.1005 DMGVYXB DI DMGVYXB DMGVYXB DN NB-506 DMGVYXB MI TTUTN1I DMGVYXB MN Human Deoxyribonucleic acid (hDNA) DMGVYXB MT DTT DMGVYXB MA Inhibitor DMGVYXB RN DNA binding properties of the indolocarbazole antitumor drug NB-506. Anticancer Drug Des. 2001 Apr-Jun;16(2-3):99-107. DMGVYXB RU https://pubmed.ncbi.nlm.nih.gov/11962518 DMTRMBL DI DMTRMBL DMTRMBL DN NBI-6024 DMTRMBL MI TTZOPHG DMTRMBL MN Insulin (INS) DMTRMBL MT DTT DMTRMBL MA Modulator DMTRMBL RN No effect of the altered peptide ligand NBI-6024 on beta-cell residual function and insulin needs in new-onset type 1 diabetes.Diabetes Care.2009 Nov;32(11):2036-40. DMTRMBL RU https://www.ncbi.nlm.nih.gov/pubmed/19690081 DMGEBUQ DI DMGEBUQ DMGEBUQ DN NC-190 DMGEBUQ MI TT0IHXV DMGEBUQ MN DNA topoisomerase II (TOP2) DMGEBUQ MT DTT DMGEBUQ MA Modulator DMGEBUQ RN The topoisomerase II-inhibitor NC-190 reduces the level of thymidine kinase mRNA in murine tumor cells. Res Commun Mol Pathol Pharmacol. 2002;111(1-4):77-87. DMGEBUQ RU https://pubmed.ncbi.nlm.nih.gov/14632316 DMWROJ5 DI DMWROJ5 DMWROJ5 DN NCX-701 DMWROJ5 MI TTK0943 DMWROJ5 MN Prostaglandin G/H synthase (COX) DMWROJ5 MT DTT DMWROJ5 MA Modulator DMWROJ5 RN Antinociceptive effects of NCX-701 (nitro-paracetamol) in neuropathic rats: enhancement of antinociception by co-administration with gabapentin. Br J Pharmacol. 2009 September; 158(2): 601-609. DMWROJ5 RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2757700/ DM6VP9U DI DM6VP9U DM6VP9U DN Nemifitide DM6VP9U MI DEJGDUW DM6VP9U MN Cytochrome P450 1A2 (CYP1A2) DM6VP9U MT DME DM6VP9U MA Metabolism DM6VP9U RN Antidepressants: Past, Present and Future. Edited by Sheldon H. Preskorn Christina Y. Stanga John P. Feighner Ruth Ross. Page: 574. DM6VP9U RU https://books.google.com/books?id=Ue3uCAAAQBAJ&pg=PA574&lpg=PA574&dq=Nemifitide+metabolism&source=bl&ots=GQLQ8gSF2U&sig=ACfU3U27jlKMS_W2CDicejY8jKnpE1dFaw&hl=zh-CN&sa=X&ved=2ahUKEwiL7fCx8rTnAhXK-GEKHc_aD0UQ6AEwAHoECAkQAQ#v=onepage&q=Nemifitide%20metabolism&f=false DM6VP9U DI DM6VP9U DM6VP9U DN Nemifitide DM6VP9U MI DECB0K3 DM6VP9U MN Cytochrome P450 2D6 (CYP2D6) DM6VP9U MT DME DM6VP9U MA Metabolism DM6VP9U RN Antidepressants: Past, Present and Future. Edited by Sheldon H. Preskorn Christina Y. Stanga John P. Feighner Ruth Ross. Page: 574. DM6VP9U RU https://books.google.com/books?id=Ue3uCAAAQBAJ&pg=PA574&lpg=PA574&dq=Nemifitide+metabolism&source=bl&ots=GQLQ8gSF2U&sig=ACfU3U27jlKMS_W2CDicejY8jKnpE1dFaw&hl=zh-CN&sa=X&ved=2ahUKEwiL7fCx8rTnAhXK-GEKHc_aD0UQ6AEwAHoECAkQAQ#v=onepage&q=Nemifitide%20metabolism&f=false DM6VP9U DI DM6VP9U DM6VP9U DN Nemifitide DM6VP9U MI DEGTFWK DM6VP9U MN Mephenytoin 4-hydroxylase (CYP2C19) DM6VP9U MT DME DM6VP9U MA Metabolism DM6VP9U RN Antidepressants: Past, Present and Future. Edited by Sheldon H. Preskorn Christina Y. Stanga John P. Feighner Ruth Ross. Page: 574. DM6VP9U RU https://books.google.com/books?id=Ue3uCAAAQBAJ&pg=PA574&lpg=PA574&dq=Nemifitide+metabolism&source=bl&ots=GQLQ8gSF2U&sig=ACfU3U27jlKMS_W2CDicejY8jKnpE1dFaw&hl=zh-CN&sa=X&ved=2ahUKEwiL7fCx8rTnAhXK-GEKHc_aD0UQ6AEwAHoECAkQAQ#v=onepage&q=Nemifitide%20metabolism&f=false DMDAUCR DI DMDAUCR DMDAUCR DN NGD 91-3 DMDAUCR MI TTEX6LM DMDAUCR MN GABA(A) receptor gamma-3 (GABRG3) DMDAUCR MT DTT DMDAUCR MA Agonist DMDAUCR RN Anxioselective compounds acting at the GABA(A) receptor benzodiazepine binding site. Curr Drug Targets CNS Neurol Disord. 2003 Aug;2(4):213-32. DMDAUCR RU https://pubmed.ncbi.nlm.nih.gov/12871032 DMOWLVF DI DMOWLVF DMOWLVF DN NGD-8243 DMOWLVF MI TTMI6F5 DMOWLVF MN Transient receptor potential cation channel V1 (TRPV1) DMOWLVF MT DTT DMOWLVF MA Blocker DMOWLVF RN Analgesic potential of TRPV1 antagonists. Biochem Pharmacol. 2009 Aug 1;78(3):211-6. DMOWLVF RU https://pubmed.ncbi.nlm.nih.gov/19481638 DMSJYEX DI DMSJYEX DMSJYEX DN Nitecapone DMSJYEX MI TTKWFB8 DMSJYEX MN Catechol-O-methyl-transferase (COMT) DMSJYEX MT DTT DMSJYEX MA Modulator DMSJYEX RN Effect of a novel catechol-O-methyltransferase inhibitor, nitecapone, on the metabolism of L-dopa in healthy volunteers. Clin Neuropharmacol. 1990 Oct;13(5):436-47. DMSJYEX RU https://pubmed.ncbi.nlm.nih.gov/2272023 DMZMQDN DI DMZMQDN DMZMQDN DN NK-1001 DMZMQDN MI TTMG98T DMZMQDN MN Heat shock protein 27 (HSP27) DMZMQDN MT DTT DMZMQDN MA Modulator DMZMQDN RN Novel therapeutic targets in the management of atrial fibrillation. Am J Cardiovasc Drugs. 2014 Dec;14(6):403-21. DMZMQDN RU https://pubmed.ncbi.nlm.nih.gov/25090973 DMZMQDN DI DMZMQDN DMZMQDN DN NK-1001 DMZMQDN MI TTHYBIX DMZMQDN MN Heat shock protein 70 (HSP70) DMZMQDN MT DTT DMZMQDN MA Modulator DMZMQDN RN Novel therapeutic targets in the management of atrial fibrillation. Am J Cardiovasc Drugs. 2014 Dec;14(6):403-21. DMZMQDN RU https://pubmed.ncbi.nlm.nih.gov/25090973 DM5OVGH DI DM5OVGH DM5OVGH DN NK-611 DM5OVGH MI TTGTQHC DM5OVGH MN DNA topoisomerase I (TOP1) DM5OVGH MT DTT DM5OVGH MA Inhibitor DM5OVGH RN DNA topoisomerase II poisons and inhibitors. Cancer Chemother Biol Response Modif. 1997;17:114-31. DM5OVGH RU https://pubmed.ncbi.nlm.nih.gov/9551211 DMV5FN1 DI DMV5FN1 DMV5FN1 DN NKS-01 DMV5FN1 MI TTSZLWK DMV5FN1 MN Aromatase (CYP19A1) DMV5FN1 MT DTT DMV5FN1 MA Inhibitor DMV5FN1 RN Effects of aromatase inhibitors on the pathobiology of the human breast, endometrial and ovarian carcinoma. Endocr Relat Cancer. 1999 Jun;6(2):197-204. DMV5FN1 RU https://pubmed.ncbi.nlm.nih.gov/10731109 DM6NPUJ DI DM6NPUJ DM6NPUJ DN NLX-P101 DM6NPUJ MI TTURQ2G DM6NPUJ MN Glutamate decarboxylase (GLUL) DM6NPUJ MT DTT DM6NPUJ MA Modulator DM6NPUJ RN NLX-P101, an adeno-associated virus gene therapy encoding glutamic acid decarboxylase, for the potential treatment of Parkinson's disease. Curr Opin Investig Drugs. 2010 Jul;11(7):813-22. DM6NPUJ RU https://pubmed.ncbi.nlm.nih.gov/20571977 DMVH3I7 DI DMVH3I7 DMVH3I7 DN NM-135 DMVH3I7 MI TTYRL6O DMVH3I7 MN Glucocorticoid receptor (NR3C1) DMVH3I7 MT DTT DMVH3I7 MA Modulator DMVH3I7 RN Local anti-inflammatory activity and systemic side effects of NM-135, a new prodrug glucocorticoid, in an experimental inflammatory rat model. Jpn J Pharmacol. 1998 Dec;78(4):505-9. DMVH3I7 RU https://pubmed.ncbi.nlm.nih.gov/9920209 DMU596F DI DMU596F DMU596F DN NMI-870 DMU596F MI TTWG9A4 DMU596F MN Adrenergic receptor alpha-2A (ADRA2A) DMU596F MT DTT DMU596F MA Modulator DMU596F RN Female Sexual Dysfunction: Therapeutic Options and Experimental Challenges. Cardiovasc Hematol Agents Med Chem. 2009 October; 7(4): 260-269. DMU596F RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3008577/ DMU596F DI DMU596F DMU596F DN NMI-870 DMU596F MI TT2NUT5 DMU596F MN Adrenergic receptor alpha-2C (ADRA2C) DMU596F MT DTT DMU596F MA Modulator DMU596F RN Female Sexual Dysfunction: Therapeutic Options and Experimental Challenges. Cardiovasc Hematol Agents Med Chem. 2009 October; 7(4): 260-269. DMU596F RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3008577/ DM2TDE7 DI DM2TDE7 DM2TDE7 DN NN8209 DM2TDE7 MI TTHXFA1 DM2TDE7 MN C5a anaphylatoxin chemotactic receptor (C5AR1) DM2TDE7 MT DTT DM2TDE7 MA Modulator DM2TDE7 RN Complement in immune and inflammatory disorders: therapeutic interventions. J Immunol. 2013 Apr 15;190(8):3839-47. DM2TDE7 RU https://pubmed.ncbi.nlm.nih.gov/23564578 DMK5WLZ DI DMK5WLZ DMK5WLZ DN Nolpitantium besilate DMK5WLZ MI TTZPO1L DMK5WLZ MN Substance-P receptor (TACR1) DMK5WLZ MT DTT DMK5WLZ MA Antagonist DMK5WLZ RN SR 140333, a novel, selective, and potent nonpeptide antagonist of the NK1 tachykinin receptor: characterization on the U373MG cell line. J Neurochem. 1994 Apr;62(4):1399-407. DMK5WLZ RU https://pubmed.ncbi.nlm.nih.gov/7510780 DMJSKUI DI DMJSKUI DMJSKUI DN Norcisapride DMJSKUI MI TTPC4TU DMJSKUI MN 5-HT 3A receptor (HTR3A) DMJSKUI MT DTT DMJSKUI MA Inhibitor DMJSKUI RN mu-Opioid/5-HT4 dual pharmacologically active agents-efforts towards an effective opioid analgesic with less GI and respiratory side effects (Part I). Bioorg Med Chem Lett. 2009 Oct 1;19(19):5679-83. DMJSKUI RU https://pubmed.ncbi.nlm.nih.gov/19700325 DMJSKUI DI DMJSKUI DMJSKUI DN Norcisapride DMJSKUI MI TT07C3Y DMJSKUI MN 5-HT 4 receptor (HTR4) DMJSKUI MT DTT DMJSKUI MA Inhibitor DMJSKUI RN mu-Opioid/5-HT4 dual pharmacologically active agents-efforts towards an effective opioid analgesic with less GI and respiratory side effects (Part I). Bioorg Med Chem Lett. 2009 Oct 1;19(19):5679-83. DMJSKUI RU https://pubmed.ncbi.nlm.nih.gov/19700325 DMJSKUI DI DMJSKUI DMJSKUI DN Norcisapride DMJSKUI MI DE4LYSA DMJSKUI MN Cytochrome P450 3A4 (CYP3A4) DMJSKUI MT DME DMJSKUI MA Metabolism DMJSKUI RN Cytochrome P450 Involvement in the biotransformation of cisapride and racemic norcisapride in vitro: differential activity of individual human CYP3A isoforms. Drug Metab Dispos. 2001 Dec;29(12):1548-54. DMJSKUI RU https://www.ncbi.nlm.nih.gov/pubmed/?term=11717173 DMYCLZR DI DMYCLZR DMYCLZR DN Norelin DMYCLZR MI TT0ID4A DMYCLZR MN Leutinizing-hormone-releasing hormone (GNRH1) DMYCLZR MT DTT DMYCLZR MA Inhibitor DMYCLZR RN Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800011623) DMYCLZR RU http://adisinsight.springer.com/drugs/800011623 DM8A64W DI DM8A64W DM8A64W DN NP-118809 DM8A64W MI TTFK1JQ DM8A64W MN Voltage-gated calcium channel alpha-2/delta-1 (CACNA2D1) DM8A64W MT DTT DM8A64W MA Inhibitor DM8A64W RN Scaffold-based design and synthesis of potent N-type calcium channel blockers. Bioorg Med Chem Lett. 2009 Nov 15;19(22):6467-72. DM8A64W RU https://pubmed.ncbi.nlm.nih.gov/19815411 DMPMR2I DI DMPMR2I DMPMR2I DN NP-50301 DMPMR2I MI TTZAYWL DMPMR2I MN Estrogen receptor (ESR) DMPMR2I MT DTT DMPMR2I MA Modulator DMPMR2I RN Therapeutic targets in dry eye syndrome. Drug News Perspect. 2008 Apr;21(3):166-76. DMPMR2I RU https://pubmed.ncbi.nlm.nih.gov/18560615 DM50PZH DI DM50PZH DM50PZH DN NP-619 DM50PZH MI TTS64P2 DM50PZH MN Androgen receptor (AR) DM50PZH MT DTT DM50PZH MA Modulator DM50PZH RN Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800028305) DM50PZH RU http://adisinsight.springer.com/drugs/800028305 DMAVZ1F DI DMAVZ1F DMAVZ1F DN NPC-567 DMAVZ1F MI TTGY8IW DMAVZ1F MN B2 bradykinin receptor (BDKRB2) DMAVZ1F MT DTT DMAVZ1F MA Inhibitor DMAVZ1F RN cis-4-(Piperazin-1-yl)-5,6,7a,8,9,10,11,11a-octahydrobenzofuro[2,3-h]quinazolin-2-amine (A-987306), a new histamine H4R antagonist that blocks pain... J Med Chem. 2008 Nov 27;51(22):7094-8. DMAVZ1F RU https://pubmed.ncbi.nlm.nih.gov/18983139 DM0CF3B DI DM0CF3B DM0CF3B DN NPS 1776 DM0CF3B MI TTB6UM0 DM0CF3B MN Fatty aldehyde dehydrogenase (ALDH3A2) DM0CF3B MT DTT DM0CF3B MA Modulator DM0CF3B RN Diverse Mechanisms of Antiepileptic Drugs in the Development Pipeline. Epilepsy Res. 2006 June; 69(3): 273-294. DM0CF3B RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1562526/ DMQPXLF DI DMQPXLF DMQPXLF DN NPS-2143 DMQPXLF MI TTBUYHA DMQPXLF MN Extracellular calcium-sensing receptor (CASR) DMQPXLF MT DTT DMQPXLF MA Antagonist DMQPXLF RN Calcium-sensing receptor antagonist (calcilytic) NPS 2143 specifically blocks the increased secretion of endogenous Abeta42 prompted by exogenous fibrillary or soluble Abeta25-35 in human cortical astrocytes and neurons-therapeutic relevance to Alzheimer's disease. Biochim Biophys Acta. 2013 Oct;1832(10):1634-52. DMQPXLF RU https://pubmed.ncbi.nlm.nih.gov/23628734 DMQ82T5 DI DMQ82T5 DMQ82T5 DN NS-220 DMQ82T5 MI TTJ584C DMQ82T5 MN Peroxisome proliferator-activated receptor alpha (PPARA) DMQ82T5 MT DTT DMQ82T5 MA Agonist DMQ82T5 RN Modulation of PPAR receptor subtype selectivity of the ligands: aliphatic chain vs aromatic ring as a spacer between pharmacophore and the lipophilic moiety. Bioorg Med Chem Lett. 2008 Dec 15;18(24):6471-5. DMQ82T5 RU https://pubmed.ncbi.nlm.nih.gov/18976908 DMVRJ8D DI DMVRJ8D DMVRJ8D DN NS-2389 DMVRJ8D MI TTVBI8W DMVRJ8D MN Dopamine transporter (DAT) DMVRJ8D MT DTT DMVRJ8D MA Modulator DMVRJ8D RN Clinical pipeline report, company report or official report of Neurosearch. DMVRJ8D RU http://neurosearch.com/Default.aspx DMVRJ8D DI DMVRJ8D DMVRJ8D DN NS-2389 DMVRJ8D MI TTAWNKZ DMVRJ8D MN Norepinephrine transporter (NET) DMVRJ8D MT DTT DMVRJ8D MA Modulator DMVRJ8D RN Clinical pipeline report, company report or official report of Neurosearch. DMVRJ8D RU http://neurosearch.com/Default.aspx DMVRJ8D DI DMVRJ8D DMVRJ8D DN NS-2389 DMVRJ8D MI TT3ROYC DMVRJ8D MN Serotonin transporter (SERT) DMVRJ8D MT DTT DMVRJ8D MA Modulator DMVRJ8D RN Clinical pipeline report, company report or official report of Neurosearch. DMVRJ8D RU http://neurosearch.com/Default.aspx DMQ8P4U DI DMQ8P4U DMQ8P4U DN NS-49 DMQ8P4U MI TT34BHT DMQ8P4U MN Adrenergic receptor alpha-1D (ADRA1D) DMQ8P4U MT DTT DMQ8P4U MA Modulator DMQ8P4U RN Pharmacokinetics of NS-49, a phenethylamine class alpha 1A-adrenoceptor agonist. 3rd communication: metabolism in rats, rabbits, dogs and monkeys, and effects on hepatic drug-metabolizing enzyme activities in rats after repeated administration. Arzneimittelforschung. 1999 Jul;49(7):612-7. DMQ8P4U RU https://pubmed.ncbi.nlm.nih.gov/10442210 DMH2QBM DI DMH2QBM DMH2QBM DN NSP-805 DMH2QBM MI TTZCG4L DMH2QBM MN Phosphodiesterase 3 (PDE3) DMH2QBM MT DTT DMH2QBM MA Modulator DMH2QBM RN [The effect of phosphodiesterase type 3 inhibitor on chorio-retinal blood flow in rabbits eyes].Nippon Ganka Gakkai Zasshi.2002 Oct;106(10):615-20. DMH2QBM RU https://www.ncbi.nlm.nih.gov/pubmed/12420371 DMGZ3DR DI DMGZ3DR DMGZ3DR DN NT-3 DMGZ3DR MI TTZHKV9 DMGZ3DR MN Neurotrophin-3 (NTF3) DMGZ3DR MT DTT DMGZ3DR MA Modulator DMGZ3DR RN NT-3. Takeda/Regeneron/Amgen. IDrugs. 2001 Jul;4(7):820-4. DMGZ3DR RU https://pubmed.ncbi.nlm.nih.gov/15995939 DMX9KYW DI DMX9KYW DMX9KYW DN NTx-488 DMX9KYW MI TTJ2TSA DMX9KYW MN Prolactin (PRL) DMX9KYW MT DTT DMX9KYW MA Modulator DMX9KYW RN Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800028330) DMX9KYW RU http://adisinsight.springer.com/drugs/800028330 DMPM58S DI DMPM58S DMPM58S DN Nuvanil DMPM58S MI TTMI6F5 DMPM58S MN Transient receptor potential cation channel V1 (TRPV1) DMPM58S MT DTT DMPM58S MA Agonist DMPM58S RN TRPV1: ON THE ROAD TO PAIN RELIEF. Curr Mol Pharmacol. 2008 November; 1(3): 255-269. DMPM58S RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2802457/ DM9HKOM DI DM9HKOM DM9HKOM DN NVP-DPP728 DM9HKOM MI TTDIGC1 DM9HKOM MN Dipeptidyl peptidase 4 (DPP-4) DM9HKOM MT DTT DM9HKOM MA Inhibitor DM9HKOM RN A three-dimensional pharmacophore model for dipeptidyl peptidase IV inhibitors. Eur J Med Chem. 2008 Aug;43(8):1603-11. DM9HKOM RU https://pubmed.ncbi.nlm.nih.gov/18207285 DMO8PN9 DI DMO8PN9 DMO8PN9 DN OBERADILOL MONOETHYL MALEATE DMO8PN9 MI TTMXGCW DMO8PN9 MN Adrenergic receptor beta-3 (ADRB3) DMO8PN9 MT DTT DMO8PN9 MA Modulator DMO8PN9 RN US patent application no. 9,062,094, Dipeptide-based prodrug linkers for aliphatic amine-containing drugs. DMO8PN9 RU http://www.google.com/patents/US9062094 DMX6GFR DI DMX6GFR DMX6GFR DN Omega interferon DMX6GFR MI TTSYFMA DMX6GFR MN Interferon alpha/beta receptor 1 (IFNAR1) DMX6GFR MT DTT DMX6GFR MA Modulator DMX6GFR RN Human interferon omega--a review. Mult Scler. 1995;1 Suppl 1:S44-7. DMX6GFR RU https://pubmed.ncbi.nlm.nih.gov/9345398 DMIZXFJ DI DMIZXFJ DMIZXFJ DN ONO-4007 DMIZXFJ MI TTOK0LR DMIZXFJ MN Toll-like receptor (TLR) DMIZXFJ MT DTT DMIZXFJ MA Modulator DMIZXFJ RN Toll-like receptors TLR2 and TLR4 initiate the innate immune response of the renal tubular epithelium to bacterial products. Clin Exp Immunol. 2006 August; 145(2): 346-356. DMIZXFJ RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1809678/ DMNEA78 DI DMNEA78 DMNEA78 DN ONO-4057 DMNEA78 MI TTVJX54 DMNEA78 MN Leukotriene B4 receptor 2 (LTB4R2) DMNEA78 MT DTT DMNEA78 MA Modulator DMNEA78 RN ONO-4057, a novel, orally active leukotriene B4 antagonist: effects on LTB4-induced neutrophil functions. Prostaglandins. 1992 Oct;44(4):261-75. DMNEA78 RU https://pubmed.ncbi.nlm.nih.gov/1332129 DMSVQK2 DI DMSVQK2 DMSVQK2 DN ONO-4819 DMSVQK2 MI TT79WV3 DMSVQK2 MN Prostaglandin E2 receptor EP4 (PTGER4) DMSVQK2 MT DTT DMSVQK2 MA Agonist DMSVQK2 RN Effect of a prostaglandin EP4 receptor agonist on early fixation of hydroxyapatite/titanium composite- and titanium-coated rough-surfaced implants ... J Biomed Mater Res A. 2010 Mar 1;92(3):1202-9. DMSVQK2 RU https://pubmed.ncbi.nlm.nih.gov/19322876 DMWS7C2 DI DMWS7C2 DMWS7C2 DN ONO-5334 DMWS7C2 MI TTDZN01 DMWS7C2 MN Cathepsin K (CTSK) DMWS7C2 MT DTT DMWS7C2 MA Inhibitor DMWS7C2 RN New approach for osteoporosis treatment: cathepsin K inhibitor, ONO-5334. Clin Calcium. 2011 Jan;21(1):64-9. DMWS7C2 RU https://pubmed.ncbi.nlm.nih.gov/21187596 DMQM4OV DI DMQM4OV DMQM4OV DN OP-2507 DMQM4OV MI TTOFYT1 DMQM4OV MN Prostacyclin receptor (PTGIR) DMQM4OV MT DTT DMQM4OV MA Modulator DMQM4OV RN Effect of a prostaglandin I(2) analog on the expression of thrombomodulin in liver and spleen endothelial cells after an extensive hepatectomy. Surg Today. 2011 Feb;41(2):230-6. DMQM4OV RU https://pubmed.ncbi.nlm.nih.gov/21264759 DMP0ARJ DI DMP0ARJ DMP0ARJ DN Opaviraline DMP0ARJ MI TT84ETX DMP0ARJ MN Human immunodeficiency virus Reverse transcriptase (HIV RT) DMP0ARJ MT DTT DMP0ARJ MA Modulator DMP0ARJ RN Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41. DMP0ARJ RU https://www.ncbi.nlm.nih.gov/pubmed/15950434 DM7OVMH DI DM7OVMH DM7OVMH DN OPC-21268 DM7OVMH MI TT2J34L DM7OVMH MN Arachidonate 5-lipoxygenase (5-LOX) DM7OVMH MT DTT DM7OVMH MA Inhibitor DM7OVMH RN Fuscoside: an anti-inflammatory marine natural product which selectively inhibits 5-lipoxygenase. Part II: Biochemical studies in the human neutrophil. J Pharmacol Exp Ther. 1992 Aug;262(2):874-82. DM7OVMH RU https://pubmed.ncbi.nlm.nih.gov/1323665 DM7OVMH DI DM7OVMH DM7OVMH DN OPC-21268 DM7OVMH MI TTPFZJ1 DM7OVMH MN Vasopressin V1 receptor (V1R) DM7OVMH MT DTT DM7OVMH MA Antagonist DM7OVMH RN Vasopressin (ADH). Nippon Rinsho. 1992 Dec;50(12):2893-900. DM7OVMH RU https://pubmed.ncbi.nlm.nih.gov/1337114 DM7OVMH DI DM7OVMH DM7OVMH DN OPC-21268 DM7OVMH MI TT4TFGN DM7OVMH MN Vasopressin V1a receptor (V1AR) DM7OVMH MT DTT DM7OVMH MA Antagonist DM7OVMH RN Nonpeptide vasopressin receptor antagonists: development of selective and orally active V1a, V2 and V1b receptor ligands. Prog Brain Res. 2002;139:197-210. DM7OVMH RU https://pubmed.ncbi.nlm.nih.gov/12436936 DMYM8OG DI DMYM8OG DMYM8OG DN OPC-28326 DMYM8OG MI TT34BHT DMYM8OG MN Adrenergic receptor alpha-1D (ADRA1D) DMYM8OG MT DTT DMYM8OG MA Antagonist DMYM8OG RN Mechanisms of action of OPC-28326, a selective hindlimb vasodilator. J Pharmacol Exp Ther. 1999 Nov;291(2):604-11. DMYM8OG RU https://pubmed.ncbi.nlm.nih.gov/10525078 DM9ORUL DI DM9ORUL DM9ORUL DN OPC-8490 DM9ORUL MI TTZCG4L DM9ORUL MN Phosphodiesterase 3 (PDE3) DM9ORUL MT DTT DM9ORUL MA Modulator DM9ORUL RN Mechanism of action of OPC-8490 in human ventricular myocardium. Circulation. 1996 Feb 15;93(4):817-25. DM9ORUL RU https://www.ncbi.nlm.nih.gov/pubmed/8641012 DMVM4NE DI DMVM4NE DMVM4NE DN OPM-3023 DMVM4NE MI TTOV74C DMVM4NE MN Bone metabolism (Bone metab) DMVM4NE MT DTT DMVM4NE MA Inhibitor DMVM4NE RN Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800030958) DMVM4NE RU http://adisinsight.springer.com/drugs/800030958 DMWZXF7 DI DMWZXF7 DMWZXF7 DN ORG-33628 DMWZXF7 MI TTHL6YX DMWZXF7 MN Progesterone (PG) DMWZXF7 MT DTT DMWZXF7 MA Modulator DMWZXF7 RN ORG 33628 and ORG 31710 to control vaginal bleeding in progestin-only contraceptive regimens. Semin Reprod Med. 2005 Feb;23(1):101-11. DMWZXF7 RU https://pubmed.ncbi.nlm.nih.gov/15714394 DMU5PFD DI DMU5PFD DMU5PFD DN Org-7797 DMU5PFD MI TTRK8B9 DMU5PFD MN Sodium channel unspecific (NaC) DMU5PFD MT DTT DMU5PFD MA Modulator DMU5PFD RN Electrophysiologic effects of Org 7797, a new steroidal antiarrhythmic agent: comparison with class 1a, 1b, and 1c drugs. J Cardiovasc Pharmacol. 1989 Aug;14(2):205-12. DMU5PFD RU https://pubmed.ncbi.nlm.nih.gov/2476592 DMW1FT0 DI DMW1FT0 DMW1FT0 DN ORG-9273 DMW1FT0 MI TTJSZTB DMW1FT0 MN Nicotinic acetylcholine receptor (nAChR) DMW1FT0 MT DTT DMW1FT0 MA Modulator DMW1FT0 RN Dose-response relation, neuromuscular blocking action, intubation conditions, and cardiovascular effects of Org 9273, a new neuromuscular blocking agent. Anesth Analg. 1991 Jun;72(6):811-6. DMW1FT0 RU https://pubmed.ncbi.nlm.nih.gov/1674648 DMZEV63 DI DMZEV63 DMZEV63 DN Org-9731 DMZEV63 MI TTZCG4L DMZEV63 MN Phosphodiesterase 3 (PDE3) DMZEV63 MT DTT DMZEV63 MA Modulator DMZEV63 RN Effects of a novel cardiotonic agent, Org 9731, on force and aequorin light transients in intact ventricular myocardium of the dog: involvement of ... J Card Fail. 1995 Mar;1(2):143-53. DMZEV63 RU https://www.ncbi.nlm.nih.gov/pubmed/9420644 DMRXHAC DI DMRXHAC DMRXHAC DN Otenzepad DMRXHAC MI TTYEG6Q DMRXHAC MN Muscarinic acetylcholine receptor M2 (CHRM2) DMRXHAC MT DTT DMRXHAC MA Antagonist DMRXHAC RN Beneficial effect of muscarinic-2 antagonist on dilated cardiomyopathy induced by autoimmune mechanism against muscarinic-2 receptor. J Cardiovasc Pharmacol. 2001 Oct;38 Suppl 1:S43-9. DMRXHAC RU https://pubmed.ncbi.nlm.nih.gov/11811358 DMHFOIX DI DMHFOIX DMHFOIX DN OxycoDex DMHFOIX MI TTN4QDT DMHFOIX MN Opioid receptor (OPR) DMHFOIX MT DTT DMHFOIX MA Modulator DMHFOIX RN Differential activation of the -opioid receptor by oxycodone and morphine in pain-related brain regions in a bone cancer pain model. Br J Pharmacol. 2013 Jan;168(2):375-88. DMHFOIX RU https://pubmed.ncbi.nlm.nih.gov/22889192 DMHFOIX DI DMHFOIX DMHFOIX DN OxycoDex DMHFOIX MI TT5TPI6 DMHFOIX MN Opioid receptor sigma 1 (OPRS1) DMHFOIX MT DTT DMHFOIX MA Modulator DMHFOIX RN Antitussives and substance abuse. Subst Abuse Rehabil. 2013 Nov 6;4:75-82. DMHFOIX RU https://pubmed.ncbi.nlm.nih.gov/24648790 DMHFOIX DI DMHFOIX DMHFOIX DN OxycoDex DMHFOIX MI TT3ROYC DMHFOIX MN Serotonin transporter (SERT) DMHFOIX MT DTT DMHFOIX MA Inhibitor DMHFOIX RN Antitussives and substance abuse. Subst Abuse Rehabil. 2013 Nov 6;4:75-82. DMHFOIX RU https://pubmed.ncbi.nlm.nih.gov/24648790 DM02ANM DI DM02ANM DM02ANM DN P-1075 DM02ANM MI TT1VOHK DM02ANM MN Potassium channel unspecific (KC) DM02ANM MT DTT DM02ANM MA Opener DM02ANM RN The effects of potassium channel opener P1075 on the human saphenous vein and human internal mammary artery. J Cardiovasc Pharmacol. 2011 Jun;57(6):648-55. DM02ANM RU https://pubmed.ncbi.nlm.nih.gov/21346595 DMWCAQD DI DMWCAQD DMWCAQD DN P1A DMWCAQD MI TTHI19T DMWCAQD MN Staphylococcus Beta-lactamase (Stap-coc blaZ) DMWCAQD MT DTT DMWCAQD MA Modulator DMWCAQD RN IPSAT P1A, a class A beta-lactamase therapy for the prevention of penicillin-induced disruption to the intestinal microflora. Curr Opin Investig Drugs. 2009 Aug;10(8):838-44. DMWCAQD RU https://pubmed.ncbi.nlm.nih.gov/19649928 DM4ZNKX DI DM4ZNKX DM4ZNKX DN PA-1806 DM4ZNKX MI TTJP4SM DM4ZNKX MN Bacterial Penicillin binding protein (Bact PBP) DM4ZNKX MT DTT DM4ZNKX MA Modulator DM4ZNKX RN Antibacterial activity of BMS-180680, a new catechol-containing monobactam. Antimicrob Agents Chemother. 1997 May;41(5):1010-6. DM4ZNKX RU https://www.ncbi.nlm.nih.gov/pubmed/9145861 DMRSMW8 DI DMRSMW8 DMRSMW8 DN PAI-2 DMRSMW8 MI TTGY7WI DMRSMW8 MN Urokinase-type plasminogen activator (PLAU) DMRSMW8 MT DTT DMRSMW8 MA Inhibitor DMRSMW8 RN Topological localization of plasminogen activator inhibitor type 2. Cytometry. 2000 May 1;40(1):32-41. DMRSMW8 RU https://pubmed.ncbi.nlm.nih.gov/10754515 DMWCLZ6 DI DMWCLZ6 DMWCLZ6 DN PALOSURAN DMWCLZ6 MI TTW5UDX DMWCLZ6 MN Urotensin II receptor (UTS2R) DMWCLZ6 MT DTT DMWCLZ6 MA Inhibitor DMWCLZ6 RN Urotensin-II receptor modulators as potential drugs. J Med Chem. 2010 Apr 8;53(7):2695-708. DMWCLZ6 RU https://pubmed.ncbi.nlm.nih.gov/20043680 DM9SYUT DI DM9SYUT DM9SYUT DN PAMAPIMOD DM9SYUT MI TTQBR95 DM9SYUT MN Stress-activated protein kinase 2a (p38 alpha) DM9SYUT MT DTT DM9SYUT MA Inhibitor DM9SYUT RN Selective p38alpha inhibitors clinically evaluated for the treatment of chronic inflammatory disorders. J Med Chem. 2010 Mar 25;53(6):2345-53. DM9SYUT RU https://pubmed.ncbi.nlm.nih.gov/19950901 DM6TPCJ DI DM6TPCJ DM6TPCJ DN Panamesine DM6TPCJ MI TT5TPI6 DM6TPCJ MN Opioid receptor sigma 1 (OPRS1) DM6TPCJ MT DTT DM6TPCJ MA Binder DM6TPCJ RN Efficacy and safety of the sigma receptor ligand EMD 57445 (panamesine) in patients with schizophrenia: an open clinical trial. Pharmacopsychiatry. 1999 Mar;32(2):68-72. DM6TPCJ RU https://pubmed.ncbi.nlm.nih.gov/10333165 DME4RSI DI DME4RSI DME4RSI DN Panomifene DME4RSI MI TTZAYWL DME4RSI MN Estrogen receptor (ESR) DME4RSI MT DTT DME4RSI MA Modulator DME4RSI RN Species differences in metabolism of panomifene, an analogue of tamoxifen. Drug Metab Dispos. 1997 Dec;25(12):1370-8. DME4RSI RU https://pubmed.ncbi.nlm.nih.gov/9394026 DM80UNM DI DM80UNM DM80UNM DN PD-134308 DM80UNM MI TTVFO0U DM80UNM MN Gastrin/cholecystokinin type B receptor (CCKBR) DM80UNM MT DTT DM80UNM MA Modulator DM80UNM RN Comparison of the effects of the cholecystokinin-B receptor antagonist, PD 134308, and the cholecystokinin-A receptor antagonist, L-364,718, on dop... Synapse. 1993 Feb;13(2):117-22. DM80UNM RU https://www.ncbi.nlm.nih.gov/pubmed/8446920 DMMYNKH DI DMMYNKH DMMYNKH DN PD-348292 DMMYNKH MI TTCIHJA DMMYNKH MN Coagulation factor Xa (F10) DMMYNKH MT DTT DMMYNKH MA Inhibitor DMMYNKH RN Pfizer. Product Development Pipeline. March 31 2009. DMMYNKH RU http://media.pfizer.com/files/research/pipeline/2009_0331/pipeline_2009_0331.pdf DMGD20T DI DMGD20T DMGD20T DN PEG-Infergen DMGD20T MI TT95SOA DMGD20T MN Interferon alpha (IFNA) DMGD20T MT DTT DMGD20T MA Modulator DMGD20T RN Patent CN102245599 B. DMGD20T RU http://www.google.com/patents/CN102245599B?cl=en DMTGBPW DI DMTGBPW DMTGBPW DN Pentisomide DMTGBPW MI TTRK8B9 DMTGBPW MN Sodium channel unspecific (NaC) DMTGBPW MT DTT DMTGBPW MA Modulator DMTGBPW RN Antiarrhythmic effect related to the plasma concentration of pentisomide in vivo and the antiarrhythmic-concentration relationship in vitro. Drugs Exp Clin Res. 1995;21(4):145-51. DMTGBPW RU https://pubmed.ncbi.nlm.nih.gov/8529527 DMFWC3O DI DMFWC3O DMFWC3O DN Perillyl alcohol DMFWC3O MI TTW2R9X DMFWC3O MN GTPase NRas (NRAS) DMFWC3O MT DTT DMFWC3O MA Modulator DMFWC3O RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2823). DMFWC3O RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2823 DMBDPN2 DI DMBDPN2 DMBDPN2 DN PF-217830 DMBDPN2 MI TTEX248 DMBDPN2 MN Dopamine D2 receptor (D2R) DMBDPN2 MT DTT DMBDPN2 MA Modulator DMBDPN2 RN Dual ligands targeting dopamine D2 and serotonin 5-HT1A receptors as new antipsychotical or anti-Parkinsonian agents.Curr Med Chem.2014;21(4):437-57. DMBDPN2 RU https://www.ncbi.nlm.nih.gov/pubmed/24164194 DMWYJHC DI DMWYJHC DMWYJHC DN PF-4480682 DMWYJHC MI TTBMV1G DMWYJHC MN GABA(A) receptor alpha-2 (GABRA2) DMWYJHC MT DTT DMWYJHC MA Modulator DMWYJHC RN WO patent application no. 2014,1515,17, Methods of improving microvascular integrity. DMWYJHC RU http://worldwide.espacenet.com/publicationDetails/biblio?DB=worldwide.espacenet.com&II=0&ND=3&adjacent=true&locale=en_EP&FT=D&date=20140925&CC=WO&NR=2014151517A1&KC=A1 DMWYJHC DI DMWYJHC DMWYJHC DN PF-4480682 DMWYJHC MI TTGXH6N DMWYJHC MN GABA(A) receptor delta (GABRD) DMWYJHC MT DTT DMWYJHC MA Modulator DMWYJHC RN WO patent application no. 2014,1515,17, Methods of improving microvascular integrity. DMWYJHC RU http://worldwide.espacenet.com/publicationDetails/biblio?DB=worldwide.espacenet.com&II=0&ND=3&adjacent=true&locale=en_EP&FT=D&date=20140925&CC=WO&NR=2014151517A1&KC=A1 DM6XEQA DI DM6XEQA DM6XEQA DN PF-610355 DM6XEQA MI TT2CJVK DM6XEQA MN Adrenergic receptor beta-2 (ADRB2) DM6XEQA MT DTT DM6XEQA MA Agonist DM6XEQA RN Inhalation by design: novel ultra-long-acting beta(2)-adrenoreceptor agonists for inhaled once-daily treatment of asthma and chronic obstructive pulmonary disease that utilize a sulfonamide agonist headgroup. J Med Chem. 2010 Sep 23;53(18):6640-52. DM6XEQA RU https://pubmed.ncbi.nlm.nih.gov/20804199 DMELXBQ DI DMELXBQ DMELXBQ DN PG-530742 DMELXBQ MI TTUZ2L5 DMELXBQ MN Matrix metalloproteinase-3 (MMP-3) DMELXBQ MT DTT DMELXBQ MA Inhibitor DMELXBQ RN Selective matrix metalloproteinase inhibition attenuates progression of left ventricular dysfunction and remodeling in dogs with chronic heart fail... Am J Physiol Heart Circ Physiol. 2006 Jun;290(6):H2522-7. DMELXBQ RU https://pubmed.ncbi.nlm.nih.gov/16428338 DM2N0TO DI DM2N0TO DM2N0TO DN Physostigmine DM2N0TO MI TT1RS9F DM2N0TO MN Acetylcholinesterase (AChE) DM2N0TO MT DTT DM2N0TO MA Inhibitor DM2N0TO RN The effects of physostigmine on acetylcholinesterase activity of CSF plasma and brain. A comparison of intravenous and intraventricular administration in beagle dogs. Neuropharmacology. 1986 Oct;25(10):1167-77. DM2N0TO RU https://pubmed.ncbi.nlm.nih.gov/3785584 DMJKN0B DI DMJKN0B DMJKN0B DN PIBROZELESIN HYDROCHLORIDE DMJKN0B MI TTUTN1I DMJKN0B MN Human Deoxyribonucleic acid (hDNA) DMJKN0B MT DTT DMJKN0B MA Binder DMJKN0B RN Use of KW-2189, a DNA minor groove-binding agent, in patients with hepatocellular carcinoma: a north central cancer treatment group (NCCTG) phase II clinical trial. J Gastrointest Cancer. 2007;38(1):10-4. DMJKN0B RU https://pubmed.ncbi.nlm.nih.gov/19065716 DMA13WI DI DMA13WI DMA13WI DN Picumeterol DMA13WI MI TT2CJVK DMA13WI MN Adrenergic receptor beta-2 (ADRB2) DMA13WI MT DTT DMA13WI MA Agonist DMA13WI RN Picumeterol: dissociation of improvement in lung function and reduction of airways hyperresponsiveness in asthmatics. Br J Clin Pharmacol. 1997 Feb;43(2):169-76. DMA13WI RU https://pubmed.ncbi.nlm.nih.gov/9131949 DM3ISKB DI DM3ISKB DM3ISKB DN PIRODAVIR DM3ISKB MI TT8R3VP DM3ISKB MN Rhinovirus Capsid protein (HRV VP) DM3ISKB MT DTT DM3ISKB MA Modulator DM3ISKB RN In vitro activity of expanded-spectrum pyridazinyl oxime ethers related to pirodavir: novel capsid-binding inhibitors with potent antipicornavirus activity. Antimicrob Agents Chemother. 2004 May;48(5):1766-72. DM3ISKB RU https://pubmed.ncbi.nlm.nih.gov/15105133 DMSQ794 DI DMSQ794 DMSQ794 DN PKI166 DMSQ794 MI TTGKNB4 DMSQ794 MN Epidermal growth factor receptor (EGFR) DMSQ794 MT DTT DMSQ794 MA Modulator DMSQ794 RN Epidermal growth factor receptor inhibitor PKI-166 governs cardiovascular protection without beneficial effects on the kidney in hypertensive 5/6 nephrectomized rats.J Pharmacol Exp Ther.2013 Jun;345(3):393-403. DMSQ794 RU https://www.ncbi.nlm.nih.gov/pubmed/23528611 DMLK5IM DI DMLK5IM DMLK5IM DN PNU-142633 DMLK5IM MI TT6MSOK DMLK5IM MN 5-HT 1D receptor (HTR1D) DMLK5IM MT DTT DMLK5IM MA Agonist DMLK5IM RN Further characterization of the 5-HT1 receptors mediating cardiac sympatho-inhibition in pithed rats: pharmacological correlation with the 5-HT1B a... Naunyn Schmiedebergs Arch Pharmacol. 2004 Feb;369(2):220-7. DMLK5IM RU https://pubmed.ncbi.nlm.nih.gov/14673512 DMP43IR DI DMP43IR DMP43IR DN Pranazepide DMP43IR MI TTCG0AL DMP43IR MN Cholecystokinin receptor type A (CCKAR) DMP43IR MT DTT DMP43IR MA Inhibitor DMP43IR RN Dual CCK-A and -B receptor antagonists (I) C9-methyl-1,4-benzodiazepines, Bioorg. Med. Chem. Lett. 7(2):169-174 (1997). DMP43IR RU http://www.sciencedirect.com/science/article/pii/S0960894X96006099 DM082ZW DI DM082ZW DM082ZW DN Prednisolone sodium metazoate DM082ZW MI DE4LYSA DM082ZW MN Cytochrome P450 3A4 (CYP3A4) DM082ZW MT DME DM082ZW MA Metabolism DM082ZW RN Induction of CYP3As in HepG2 cells by several drugs. Association between induction of CYP3A4 and expression of glucocorticoid receptor. Biol Pharm Bull. 2003 Apr;26(4):510-7. DM082ZW RU https://www.ncbi.nlm.nih.gov/pubmed/?term=12673034 DM082ZW DI DM082ZW DM082ZW DN Prednisolone sodium metazoate DM082ZW MI TTP3UTW DM082ZW MN Steroid hormone receptor ERR (ESRR) DM082ZW MT DTT DM082ZW MA Modulator DM082ZW RN Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41. DM082ZW RU https://www.ncbi.nlm.nih.gov/pubmed/15950434 DMLOGR3 DI DMLOGR3 DMLOGR3 DN Pro 542 DMLOGR3 MI TTBYP1X DMLOGR3 MN Human immunodeficiency virus Envelope glycoprotein gp120 (HIV gp120) DMLOGR3 MT DTT DMLOGR3 MA Modulator DMLOGR3 RN Treatment of advanced human immunodeficiency virus type 1 disease with the viral entry inhibitor PRO 542. Antimicrob Agents Chemother. 2004 Feb;48(2):423-9. DMLOGR3 RU https://www.ncbi.nlm.nih.gov/pubmed/14742190 DM8U3R6 DI DM8U3R6 DM8U3R6 DN PROXODOLOL DM8U3R6 MI TTMXGCW DM8U3R6 MN Adrenergic receptor beta-3 (ADRB3) DM8U3R6 MT DTT DM8U3R6 MA Modulator DM8U3R6 RN The efficacy of proxodolol, a new beta-adrenoblockader with alpha-adrenoblockader properties, in its single use in patients with stable stenocardia of effort. Eksp Klin Farmakol. 1994 May-Jun;57(3):47-50. DM8U3R6 RU https://pubmed.ncbi.nlm.nih.gov/7914121 DMHDP9R DI DMHDP9R DMHDP9R DN PRS-211375 iv DMHDP9R MI TTMSFAW DMHDP9R MN Cannabinoid receptor 2 (CB2) DMHDP9R MT DTT DMHDP9R MA Agonist DMHDP9R RN Brain CB2 Receptors: Implications for Neuropsychiatric Disorders. Pharmaceuticals (Basel) 2010 August; 3(8): 2517-2553. DMHDP9R RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4033937/ DMN4RV0 DI DMN4RV0 DMN4RV0 DN PRX-00023 DMN4RV0 MI TTSQIFT DMN4RV0 MN 5-HT 1A receptor (HTR1A) DMN4RV0 MT DTT DMN4RV0 MA Modulator DMN4RV0 RN PRX-00023, a selective serotonin 1A receptor agonist, reduces ultrasonic vocalizations in infant rats bred for high infantile anxiety.Pharmacol Biochem Behav.2009 Nov;94(1):8-15. DMN4RV0 RU https://www.ncbi.nlm.nih.gov/pubmed/19576924 DMT0KB1 DI DMT0KB1 DMT0KB1 DN PSD-506 DMT0KB1 MI TTYEG6Q DMT0KB1 MN Muscarinic acetylcholine receptor M2 (CHRM2) DMT0KB1 MT DTT DMT0KB1 MA Modulator DMT0KB1 RN Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41. DMT0KB1 RU https://www.ncbi.nlm.nih.gov/pubmed/15950434 DMT0KB1 DI DMT0KB1 DMT0KB1 DN PSD-506 DMT0KB1 MI TTQ13Z5 DMT0KB1 MN Muscarinic acetylcholine receptor M3 (CHRM3) DMT0KB1 MT DTT DMT0KB1 MA Modulator DMT0KB1 RN Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41. DMT0KB1 RU https://www.ncbi.nlm.nih.gov/pubmed/15950434 DMR1OJM DI DMR1OJM DMR1OJM DN PSD-508 DMR1OJM MI TTK0943 DMR1OJM MN Prostaglandin G/H synthase (COX) DMR1OJM MT DTT DMR1OJM MA Inhibitor DMR1OJM RN CN patent application no. 104797935, A method for prognosis and treatment of cancer metastasis. DMR1OJM RU http://www.google.com/patents/CN104797935A?cl=en DMDOFE7 DI DMDOFE7 DMDOFE7 DN PSN357 DMDOFE7 MI TT31JXP DMDOFE7 MN Myophosphorylase (PYGM) DMDOFE7 MT DTT DMDOFE7 MA Modulator DMDOFE7 RN PhRMA DMDOFE7 RU http://phrma.org/sites/default/files/pdf/2015-neurological-disorders_drug-list.pdf DMMF9RS DI DMMF9RS DMMF9RS DN PSN-9301 DMMF9RS MI TTDIGC1 DMMF9RS MN Dipeptidyl peptidase 4 (DPP-4) DMMF9RS MT DTT DMMF9RS MA Inhibitor DMMF9RS RN Navigating the chemical space of dipeptidyl peptidase-4 inhibitors. Drug Des Devel Ther. 2015; 9: 4515-4549. DMMF9RS RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4539085/ DMYM9JL DI DMYM9JL DMYM9JL DN PT-14 DMYM9JL MI TTD0CIQ DMYM9JL MN Melanocortin receptor 4 (MC4R) DMYM9JL MT DTT DMYM9JL MA Agonist DMYM9JL RN The protective effects of the melanocortin receptor (MCR) agonist, melanotan-II (MTII), against binge-like ethanol drinking are facilitated by deletion of the MC3 receptor in mice. Neuropeptides. 2014 Feb;48(1):47-51. DMYM9JL RU https://pubmed.ncbi.nlm.nih.gov/24290566 DMGO2AV DI DMGO2AV DMGO2AV DN PTI-701 DMGO2AV MI TTN4QDT DMGO2AV MN Opioid receptor (OPR) DMGO2AV MT DTT DMGO2AV MA Modulator DMGO2AV RN Clinical pipeline report, company report or official report of Pain Therapeutics. DMGO2AV RU http://www.paintrials.com/ DMI8T41 DI DMI8T41 DMI8T41 DN Pumafentrine DMI8T41 MI TTZCG4L DMI8T41 MN Phosphodiesterase 3 (PDE3) DMI8T41 MT DTT DMI8T41 MA Modulator DMI8T41 RN The selective phosphodiesterase 4 inhibitor roflumilast and phosphodiesterase 3/4 inhibitor pumafentrine reduce clinical score and TNF expression in experimental colitis in mice.PLoS One.2013;8(2):e56867. DMI8T41 RU https://www.ncbi.nlm.nih.gov/pubmed/23468885 DMWE6V1 DI DMWE6V1 DMWE6V1 DN Putrescine DMWE6V1 MI DETECWH DMWE6V1 MN Amiloride-sensitive amine oxidase (AOC1) DMWE6V1 MT DME DMWE6V1 MA Metabolism DMWE6V1 RN Putrescine metabolism and the study of diamine oxidase activity in vivo. Agents Actions. 1981 Apr;11(1-2):20-7. DMWE6V1 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=6787849 DMWE6V1 DI DMWE6V1 DMWE6V1 DN Putrescine DMWE6V1 MI TTUMGNO DMWE6V1 MN Ornithine decarboxylase (ODC1) DMWE6V1 MT DTT DMWE6V1 MA Inhibitor DMWE6V1 RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMWE6V1 RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMWE6V1 DI DMWE6V1 DMWE6V1 DN Putrescine DMWE6V1 MI TTBFROQ DMWE6V1 MN S-adenosylmethionine decarboxylase proenzyme (AMD1) DMWE6V1 MT DTT DMWE6V1 MA Inhibitor DMWE6V1 RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMWE6V1 RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMRODZS DI DMRODZS DMRODZS DN PV-707 DMRODZS MI TTDB5IS DMRODZS MN Receptor unspecific (Rec) DMRODZS MT DTT DMRODZS MA Modulator DMRODZS RN EP patent application no. 1904089, Promotion of epithelial regeneration. DMRODZS RU http://www.google.com/patents/EP1904089A2?cl=en DMD308S DI DMD308S DMD308S DN Pyrazinoylguanidine DMD308S MI TTRK8B9 DMD308S MN Sodium channel unspecific (NaC) DMD308S MT DTT DMD308S MA Modulator DMD308S RN Design, synthesis, and structure-activity relationships of novel 2-substituted pyrazinoylguanidine epithelial sodium channel blockers: drugs for cystic fibrosis and chronic bronchitis. J Med Chem. 2006 Jul 13;49(14):4098-115. DMD308S RU https://pubmed.ncbi.nlm.nih.gov/16821771 DMTGFV6 DI DMTGFV6 DMTGFV6 DN PYY3-36 DMTGFV6 MI TTJ6WK9 DMTGFV6 MN Neuropeptide Y receptor type 2 (NPY2R) DMTGFV6 MT DTT DMTGFV6 MA Agonist DMTGFV6 RN Emerging drugs for obesity: linking novel biological mechanisms to pharmaceutical pipelines. Expert Opin Emerg Drugs. 2005 Aug;10(3):643-60. DMTGFV6 RU https://pubmed.ncbi.nlm.nih.gov/16083333 DM2Q5IS DI DM2Q5IS DM2Q5IS DN R-1438 DM2Q5IS MI TTDIGC1 DM2Q5IS MN Dipeptidyl peptidase 4 (DPP-4) DM2Q5IS MT DTT DM2Q5IS MA Inhibitor DM2Q5IS RN Emerging drug candidates of dipeptidyl peptidase IV (DPP IV) inhibitor class for the treatment of Type 2 Diabetes. Curr Drug Targets. 2009 Jan;10(1):71-87. DM2Q5IS RU https://pubmed.ncbi.nlm.nih.gov/19149538 DMAPRGQ DI DMAPRGQ DMAPRGQ DN R-1578 DMAPRGQ MI TTXJ47W DMAPRGQ MN Metabotropic glutamate receptor 2 (mGluR2) DMAPRGQ MT DTT DMAPRGQ MA Antagonist DMAPRGQ RN Clinical pipeline report, company report or official report of Roche. DMAPRGQ RU http://www.roche.com/research_and_development/who_we_are_how_we_work/pipeline.htm DMAPRGQ DI DMAPRGQ DMAPRGQ DN R-1578 DMAPRGQ MI TT8A9EF DMAPRGQ MN Metabotropic glutamate receptor 3 (mGluR3) DMAPRGQ MT DTT DMAPRGQ MA Antagonist DMAPRGQ RN Clinical pipeline report, company report or official report of Roche. DMAPRGQ RU http://www.roche.com/research_and_development/who_we_are_how_we_work/pipeline.htm DMGVRQ2 DI DMGVRQ2 DMGVRQ2 DN R-18893 DMGVRQ2 MI TT84ETX DMGVRQ2 MN Human immunodeficiency virus Reverse transcriptase (HIV RT) DMGVRQ2 MT DTT DMGVRQ2 MA Modulator DMGVRQ2 RN EP patent application no. 0767664, Combination therapy for hiv infection. DMGVRQ2 RU http://www.google.com/patents/EP0767664A2?cl=en DMEJNM1 DI DMEJNM1 DMEJNM1 DN R-343 DMEJNM1 MI TTOU65C DMEJNM1 MN Tyrosine-protein kinase SYK (SYK) DMEJNM1 MT DTT DMEJNM1 MA Inhibitor DMEJNM1 RN A novel Syk kinase inhibitor suitable for inhalation: R-343(. Expert Opin Ther Pat. 2009 Oct;19(10):1469-72. DMEJNM1 RU https://pubmed.ncbi.nlm.nih.gov/19552507 DM5NWPD DI DM5NWPD DM5NWPD DN R-568 DM5NWPD MI TTBUYHA DM5NWPD MN Extracellular calcium-sensing receptor (CASR) DM5NWPD MT DTT DM5NWPD MA Agonist DM5NWPD RN Mixed-effects modeling of the pharmacodynamic response to the calcimimetic agent R-568. Clin Pharmacol Ther. 1999 Jan;65(1):40-9. DM5NWPD RU https://pubmed.ncbi.nlm.nih.gov/9951429 DMJTOP8 DI DMJTOP8 DMJTOP8 DN R-61837 DMJTOP8 MI TT2Y1AN DMJTOP8 MN Rhinovirus Protein 1 (HRV P1D) DMJTOP8 MT DTT DMJTOP8 MA Modulator DMJTOP8 RN In vitro activity of R 61837, a new antirhinovirus compound. Arch Virol. 1988;101(3-4):155-67. DMJTOP8 RU https://pubmed.ncbi.nlm.nih.gov/2845889 DM2NTJY DI DM2NTJY DM2NTJY DN R-68151 DM2NTJY MI TT2J34L DM2NTJY MN Arachidonate 5-lipoxygenase (5-LOX) DM2NTJY MT DTT DM2NTJY MA Inhibitor DM2NTJY RN Preview of potential therapeutic applications of leukotriene B4 inhibitors in dermatology. Skin Pharmacol Appl Skin Physiol. 2000 Sep-Oct;13(5):235-45. DM2NTJY RU https://pubmed.ncbi.nlm.nih.gov/10940813 DM2NTJY DI DM2NTJY DM2NTJY DN R-68151 DM2NTJY MI TTCIHJA DM2NTJY MN Coagulation factor Xa (F10) DM2NTJY MT DTT DM2NTJY MA Inhibitor DM2NTJY RN Synthesis and evaluation of 1-arylsulfonyl-3-piperazinone derivatives as a factor Xa inhibitor II. Substituent effect on biological activities. Chem Pharm Bull (Tokyo). 2002 Sep;50(9):1187-94. DM2NTJY RU https://pubmed.ncbi.nlm.nih.gov/12237534 DM9BI3Y DI DM9BI3Y DM9BI3Y DN R7128 DM9BI3Y MI TTMVBWH DM9BI3Y MN Hepatitis C virus RNA-directed RNA polymerase (HCV NS5B) DM9BI3Y MT DTT DM9BI3Y MA Inhibitor DM9BI3Y RN Clinical pipeline report, company report or official report of Roche (2009). DM9BI3Y RU http://www.roche.com/research_and_development/pipeline/roche_pharma_pipeline.htm DM4O7KA DI DM4O7KA DM4O7KA DN R-84760 DM4O7KA MI TTQW87Y DM4O7KA MN Opioid receptor kappa (OPRK1) DM4O7KA MT DTT DM4O7KA MA Agonist DM4O7KA RN Effects of R-84760, a selective kappa-opioid receptor agonist, on nociceptive reflex in isolated neonatal rat spinal cord. Eur J Pharmacol. 1998 Feb 19;343(2-3):171-7. DM4O7KA RU https://pubmed.ncbi.nlm.nih.gov/9570465 DMDOETQ DI DMDOETQ DMDOETQ DN R-873 DMDOETQ MI TTXEU7H DMDOETQ MN GPCR unspecific (GPCR) DMDOETQ MT DTT DMDOETQ MA Agonist DMDOETQ RN Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800020830) DMDOETQ RU http://adisinsight.springer.com/drugs/800020830 DMRZI3C DI DMRZI3C DMRZI3C DN R-87366 DMRZI3C MI TT5FNQT DMRZI3C MN Human immunodeficiency virus Protease (HIV PR) DMRZI3C MT DTT DMRZI3C MA Inhibitor DMRZI3C RN In vitro and ex vivo anti-human immunodeficiency virus (HIV) activities of a new water-soluble HIV protease inhibitor, R-87366, containing (2S,3S)-3-amino-2-hydroxy-4-phenylbutanoic acid. Biol Pharm Bull. 1997 Feb;20(2):175-80. 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Indian J Pharmacol. 2008 October; 40(Suppl 2): S91-S97. DM7OD3J RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3086155/ DMIEFH0 DI DMIEFH0 DMIEFH0 DN REC-15/3079 DMIEFH0 MI TTSQIFT DMIEFH0 MN 5-HT 1A receptor (HTR1A) DMIEFH0 MT DTT DMIEFH0 MA Antagonist DMIEFH0 RN N-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-N-(2-nitrophenyl) cyclohexanecarboxamide: a novel pre- and postsynaptic 5-hydroxytryptamine(1A) receptor antagonist active on the lower urinary tract. JPharmacol Exp Ther. 2001 Dec;299(3):1027-37. DMIEFH0 RU https://pubmed.ncbi.nlm.nih.gov/11714892 DMX4ZWK DI DMX4ZWK DMX4ZWK DN REC-15-2739 DMX4ZWK MI TTNGILX DMX4ZWK MN Adrenergic receptor alpha-1A (ADRA1A) DMX4ZWK MT DTT DMX4ZWK MA Inhibitor DMX4ZWK RN Pharmacophore identification of alpha(1A)-adrenoceptor antagonists. Bioorg Med Chem Lett. 2005 Feb 1;15(3):657-64. DMX4ZWK RU https://pubmed.ncbi.nlm.nih.gov/15664832 DMX4ZWK DI DMX4ZWK DMX4ZWK DN REC-15-2739 DMX4ZWK MI TT34BHT DMX4ZWK MN Adrenergic receptor alpha-1D (ADRA1D) DMX4ZWK MT DTT DMX4ZWK MA Modulator DMX4ZWK RN Functional antagonistic activity of Rec 15/2739, a novel alpha-1 antagonist selective for the lower urinary tract, on noradrenaline-induced contraction of human prostate and mesenteric artery. J Pharmacol Exp Ther. 1996 Jun;277(3):1237-46. DMX4ZWK RU https://pubmed.ncbi.nlm.nih.gov/8667184 DMIN73Y DI DMIN73Y DMIN73Y DN Reglixane DMIN73Y MI TTJ584C DMIN73Y MN Peroxisome proliferator-activated receptor alpha (PPARA) DMIN73Y MT DTT DMIN73Y MA Modulator DMIN73Y RN Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41. DMIN73Y RU https://www.ncbi.nlm.nih.gov/pubmed/15950434 DMIN73Y DI DMIN73Y DMIN73Y DN Reglixane DMIN73Y MI TTZMAO3 DMIN73Y MN Peroxisome proliferator-activated receptor gamma (PPAR-gamma) DMIN73Y MT DTT DMIN73Y MA Modulator DMIN73Y RN Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41. DMIN73Y RU https://www.ncbi.nlm.nih.gov/pubmed/15950434 DMLJEFH DI DMLJEFH DMLJEFH DN Relacatib DMLJEFH MI TTDZN01 DMLJEFH MN Cathepsin K (CTSK) DMLJEFH MT DTT DMLJEFH MA Inhibitor DMLJEFH RN The discovery of odanacatib (MK-0822), a selective inhibitor of cathepsin K. Bioorg Med Chem Lett. 2008 Feb 1;18(3):923-8. DMLJEFH RU https://pubmed.ncbi.nlm.nih.gov/18226527 DMHCBQS DI DMHCBQS DMHCBQS DN ReN-1869 DMHCBQS MI TTTIBOJ DMHCBQS MN Histamine H1 receptor (H1R) DMHCBQS MT DTT DMHCBQS MA Antagonist DMHCBQS RN ReN 1869, a novel tricyclic antihistamine, is active against neurogenic pain and inflammation. Eur J Pharmacol. 2002 Jan 18;435(1):43-57. DMHCBQS RU https://pubmed.ncbi.nlm.nih.gov/11790377 DMSOALX DI DMSOALX DMSOALX DN Repifermin DMSOALX MI TTNPEFX DMSOALX MN Fibroblast growth factor-10 (FGF10) DMSOALX MT DTT DMSOALX MA Modulator DMSOALX RN Repifermin (keratinocyte growth factor-2) for the treatment of active ulcerative colitis: a randomized, double-blind, placebo-controlled, dose-escalation trial. Aliment Pharmacol Ther. 2003 Jun 1;17(11):1355-64. DMSOALX RU https://pubmed.ncbi.nlm.nih.gov/12786629 DM3EAYN DI DM3EAYN DM3EAYN DN RESEQUINIL DM3EAYN MI TTEX6LM DM3EAYN MN GABA(A) receptor gamma-3 (GABRG3) DM3EAYN MT DTT DM3EAYN MA Agonist DM3EAYN RN WO patent application no. 2010,0024,51, Naphthyridin derivatives. DM3EAYN RU http://worldwide.espacenet.com/publicationDetails/biblio?DB=worldwide.espacenet.com&II=0&ND=3&adjacent=true&locale=en_EP&FT=D&date=20100107&CC=WO&NR=2010002451A1&KC=A1 DM3TU7D DI DM3TU7D DM3TU7D DN RG1578 DM3TU7D MI TTXJ47W DM3TU7D MN Metabotropic glutamate receptor 2 (mGluR2) DM3TU7D MT DTT DM3TU7D MA Modulator DM3TU7D RN Company report (Roche pipeline: 15 April 2014) DM3TU7D RU http://www.roche.com/irp1q14e-a.pdf DM5KJGB DI DM5KJGB DM5KJGB DN RG7160 DM5KJGB MI TTGKNB4 DM5KJGB MN Epidermal growth factor receptor (EGFR) DM5KJGB MT DTT DM5KJGB MA Modulator DM5KJGB RN GA201 (RG7160): a novel, humanized, glycoengineered anti-EGFR antibody with enhanced ADCC and superior in vivo efficacy compared with cetuximab. Clin Cancer Res. 2013 Mar 1;19(5):1126-38. DM5KJGB RU https://pubmed.ncbi.nlm.nih.gov/23209031 DMCQRS2 DI DMCQRS2 DMCQRS2 DN RG7414 DMCQRS2 MI TT7WD0H DMCQRS2 MN Epidermal growth factor-like protein 7 (EGFL7) DMCQRS2 MT DTT DMCQRS2 MA Modulator DMCQRS2 RN Anti-EGFL7 antibodies enhance stress-induced endothelial cell death and anti-VEGF efficacy. J Clin Invest. 2013 September 3; 123(9): 3997-4009. DMCQRS2 RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3754254/ DM32IV4 DI DM32IV4 DM32IV4 DN RG7593 DM32IV4 MI TTM6QSK DM32IV4 MN B-cell receptor CD22 (CD22) DM32IV4 MT DTT DM32IV4 MA Modulator DM32IV4 RN Clinical pipeline report, company report or official report of Roche. DM32IV4 RU http://www.roche.com/irp3q12e-a.pdf DMPQC18 DI DMPQC18 DMPQC18 DN RG7685 DMPQC18 MI TTYMKBE DMPQC18 MN Gastric inhibitory polypeptide receptor (GIPR) DMPQC18 MT DTT DMPQC18 MA Modulator DMPQC18 RN Company report (Roche pipeline: October 16, 2012) DMPQC18 RU http://www.roche.com/irp3q12e-a.pdf DMPQC18 DI DMPQC18 DMPQC18 DN RG7685 DMPQC18 MI TTVIMDE DMPQC18 MN Glucagon-like peptide 1 receptor (GLP1R) DMPQC18 MT DTT DMPQC18 MA Modulator DMPQC18 RN Company report (Roche pipeline: October 16, 2012) DMPQC18 RU http://www.roche.com/irp3q12e-a.pdf DMI1XQ9 DI DMI1XQ9 DMI1XQ9 DN RG7697 DMI1XQ9 MI TTYMKBE DMI1XQ9 MN Gastric inhibitory polypeptide receptor (GIPR) DMI1XQ9 MT DTT DMI1XQ9 MA Modulator DMI1XQ9 RN Company report (Roche pipeline: 16 October 2014) DMI1XQ9 RU http://www.roche.com/dam/jcr:d7744c7f-f7de-46b5-b028-df69d7bc3a05/en/irp3q14e-a.pdf DMQ4IKZ DI DMQ4IKZ DMQ4IKZ DN RHIZOXIN DMQ4IKZ MI TTML2WA DMQ4IKZ MN Tubulin (TUB) DMQ4IKZ MT DTT DMQ4IKZ MA Inhibitor DMQ4IKZ RN Tubulin polymerization inhibitors with a fluorinated phthalimide skeleton derived from thalidomide. 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Fundam Clin Pharmacol. 1995;9(2):119-28. DME5MGP RU https://pubmed.ncbi.nlm.nih.gov/7628824 DMNRGB7 DI DMNRGB7 DMNRGB7 DN Risotilide DMNRGB7 MI TT1VOHK DMNRGB7 MN Potassium channel unspecific (KC) DMNRGB7 MT DTT DMNRGB7 MA Opener DMNRGB7 RN Electrophysiological effects of left ventricular hypertrophy. Effect of calcium and potassium channel blockade. Circulation. 1991 Jun;83(6):2067-75. DMNRGB7 RU https://pubmed.ncbi.nlm.nih.gov/1645624 DMVHT6F DI DMVHT6F DMVHT6F DN Rispenzepine DMVHT6F MI TTZ9SOR DMVHT6F MN Muscarinic acetylcholine receptor M1 (CHRM1) DMVHT6F MT DTT DMVHT6F MA Antagonist DMVHT6F RN Evidence for prejunctional muscarinic autoreceptors in human and guinea pig trachea. Am J Respir Crit Care Med. 1995 Sep;152(3):872-8. DMVHT6F RU https://pubmed.ncbi.nlm.nih.gov/7663798 DMOZEN6 DI DMOZEN6 DMOZEN6 DN RJR-2403 DMOZEN6 MI TTJSZTB DMOZEN6 MN Nicotinic acetylcholine receptor (nAChR) DMOZEN6 MT DTT DMOZEN6 MA Agonist DMOZEN6 RN The therapeutic potential of nicotinic acetylcholine receptor agonists for pain control. Expert Opin Investig Drugs. 2001 Oct;10(10):1819-30. DMOZEN6 RU https://pubmed.ncbi.nlm.nih.gov/11772288 DMHSUQ1 DI DMHSUQ1 DMHSUQ1 DN R-ketoprofen DMHSUQ1 MI TTMWT8Z DMHSUQ1 MN C-X-C chemokine receptor type 1 (CXCR1) DMHSUQ1 MT DTT DMHSUQ1 MA Inhibitor DMHSUQ1 RN 2-Arylpropionic CXC chemokine receptor 1 (CXCR1) ligands as novel noncompetitive CXCL8 inhibitors. J Med Chem. 2005 Jun 30;48(13):4312-31. DMHSUQ1 RU https://pubmed.ncbi.nlm.nih.gov/15974585 DMHSUQ1 DI DMHSUQ1 DMHSUQ1 DN R-ketoprofen DMHSUQ1 MI TT30C9G DMHSUQ1 MN C-X-C chemokine receptor type 2 (CXCR2) DMHSUQ1 MT DTT DMHSUQ1 MA Inhibitor DMHSUQ1 RN 2-Arylpropionic CXC chemokine receptor 1 (CXCR1) ligands as novel noncompetitive CXCL8 inhibitors. J Med Chem. 2005 Jun 30;48(13):4312-31. DMHSUQ1 RU https://pubmed.ncbi.nlm.nih.gov/15974585 DMHSUQ1 DI DMHSUQ1 DMHSUQ1 DN R-ketoprofen DMHSUQ1 MI TTCTE1G DMHSUQ1 MN Interleukin-8 (IL8) DMHSUQ1 MT DTT DMHSUQ1 MA Inhibitor DMHSUQ1 RN Structure-Activity Relationship of novel phenylacetic CXCR1 inhibitors. Bioorg Med Chem Lett. 2009 Aug 1;19(15):4026-30. DMHSUQ1 RU https://pubmed.ncbi.nlm.nih.gov/19560921 DMHSUQ1 DI DMHSUQ1 DMHSUQ1 DN R-ketoprofen DMHSUQ1 MI TT8NGED DMHSUQ1 MN Prostaglandin G/H synthase 1 (COX-1) DMHSUQ1 MT DTT DMHSUQ1 MA Inhibitor DMHSUQ1 RN 2-Arylpropionic CXC chemokine receptor 1 (CXCR1) ligands as novel noncompetitive CXCL8 inhibitors. J Med Chem. 2005 Jun 30;48(13):4312-31. DMHSUQ1 RU https://pubmed.ncbi.nlm.nih.gov/15974585 DMHSUQ1 DI DMHSUQ1 DMHSUQ1 DN R-ketoprofen DMHSUQ1 MI TTVKILB DMHSUQ1 MN Prostaglandin G/H synthase 2 (COX-2) DMHSUQ1 MT DTT DMHSUQ1 MA Inhibitor DMHSUQ1 RN 2-Arylpropionic CXC chemokine receptor 1 (CXCR1) ligands as novel noncompetitive CXCL8 inhibitors. J Med Chem. 2005 Jun 30;48(13):4312-31. DMHSUQ1 RU https://pubmed.ncbi.nlm.nih.gov/15974585 DM5P1KQ DI DM5P1KQ DM5P1KQ DN RN6G DM5P1KQ MI TTE4KHA DM5P1KQ MN Amyloid beta A4 protein (APP) DM5P1KQ MT DTT DM5P1KQ MA Inhibitor DM5P1KQ RN Advances in the management of macular degeneration. F1000Prime Rep. 2014; 6: 29. DM5P1KQ RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4017905/ DME9V0I DI DME9V0I DME9V0I DN RNAPc2 DME9V0I MI TTF0EGX DME9V0I MN Coagulation factor VII (F7) DME9V0I MT DTT DME9V0I MA Modulator DME9V0I RN rNAPc2 inhibits colorectal cancer in mice through tissue factor. Clin Cancer Res. 2009 Jan 1;15(1):208-16. DME9V0I RU https://pubmed.ncbi.nlm.nih.gov/19118048 DM4YA63 DI DM4YA63 DM4YA63 DN Ro-23-9424 DM4YA63 MI TTN6J5F DM4YA63 MN Bacterial DNA gyrase (Bact gyrase) DM4YA63 MT DTT DM4YA63 MA Modulator DM4YA63 RN Mode of action of the dual-action cephalosporin Ro 23-9424. Antimicrob Agents Chemother. 1989 Jul;33(7):1067-71. DM4YA63 RU https://www.ncbi.nlm.nih.gov/pubmed/2675755 DM01MRZ DI DM01MRZ DM01MRZ DN Ro-24-4736 DM01MRZ MI TTQL5VC DM01MRZ MN Platelet-activating factor receptor (PTAFR) DM01MRZ MT DTT DM01MRZ MA Antagonist DM01MRZ RN Pharmacology of a potent platelet-activating factor antagonist: Ro 24-4736. J Pharmacol Exp Ther. 1991 Oct;259(1):78-85. DM01MRZ RU https://pubmed.ncbi.nlm.nih.gov/1656030 DMPB80O DI DMPB80O DMPB80O DN RO-26-9228 DMPB80O MI TTK59TV DMPB80O MN Vitamin D3 receptor (VDR) DMPB80O MT DTT DMPB80O MA Agonist DMPB80O RN Evidence for tissue- and cell-type selective activation of the vitamin D receptor by Ro-26-9228, a noncalcemic analog of vitamin D3. J Cell Biochem. 2003 Feb 1;88(2):267-73. DMPB80O RU https://pubmed.ncbi.nlm.nih.gov/12520525 DMH912O DI DMH912O DMH912O DN RO-48-6791 DMH912O MI TTEX6LM DMH912O MN GABA(A) receptor gamma-3 (GABRG3) DMH912O MT DTT DMH912O MA Modulator DMH912O RN Integrated pharmacokinetics and pharmacodynamics of Ro 48-6791, a new benzodiazepine, in comparison with midazolam during first administration to healthy male subjects. Br J Clin Pharmacol. 1997 Nov;44(5):477-86. DMH912O RU https://pubmed.ncbi.nlm.nih.gov/9384465 DMZAISC DI DMZAISC DMZAISC DN Robalzotan DMZAISC MI TTSQIFT DMZAISC MN 5-HT 1A receptor (HTR1A) DMZAISC MT DTT DMZAISC MA Antagonist DMZAISC RN Use of PET and the radioligand [carbonyl-(11)C]WAY-100635 in psychotropic drug development. Nucl Med Biol. 2000 Jul;27(5):515-21. DMZAISC RU https://pubmed.ncbi.nlm.nih.gov/10962260 DM6OSPQ DI DM6OSPQ DM6OSPQ DN Rofleponide DM6OSPQ MI TTPNQAC DM6OSPQ MN Estrogen-related receptor-alpha (ESRRA) DM6OSPQ MT DTT DM6OSPQ MA Modulator DM6OSPQ RN Direct activation of GABAA receptors by loreclezole, an anticonvulsant drug with selectivity for the beta-subunit. Neuropharmacology. 1996;35(12):1753-60. DM6OSPQ RU https://pubmed.ncbi.nlm.nih.gov/9076754 DM8Q7XV DI DM8Q7XV DM8Q7XV DN Rolafagrel DM8Q7XV MI TTKNWZ4 DM8Q7XV MN Thromboxane-A synthase (TBXAS1) DM8Q7XV MT DTT DM8Q7XV MA Inhibitor DM8Q7XV RN Inhibition by FCE 22178 of platelet and glomerular thromboxane synthase in animal and human kidney disease. Adv Prostaglandin Thromboxane Leukot Res. 1991;21B:707-10. DM8Q7XV RU https://pubmed.ncbi.nlm.nih.gov/1825400 DMYDWHN DI DMYDWHN DMYDWHN DN Romergoline DMYDWHN MI TTEX248 DMYDWHN MN Dopamine D2 receptor (D2R) DMYDWHN MT DTT DMYDWHN MA Modulator DMYDWHN RN CA patent application no. 648479, Implants for the treatment of dopamine associated states. DMYDWHN RU https://www.google.com.ar/patents/CA2648479A1?cl=en&hl=zh-CN DM10ZJP DI DM10ZJP DM10ZJP DN Ronacaleret DM10ZJP MI TTBUYHA DM10ZJP MN Extracellular calcium-sensing receptor (CASR) DM10ZJP MT DTT DM10ZJP MA Antagonist DM10ZJP RN Clinical pipeline report, company report or official report of GlaxoSmithKline (2009). DM10ZJP RU http://www.gsk.com/investors/product_pipeline/docs/gsk-pipeline-feb09.pdf DMNBUS7 DI DMNBUS7 DMNBUS7 DN Rozrolimupab DMNBUS7 MI TTLCKI8 DMNBUS7 MN Blood group Rh(D) polypeptide (RHD) DMNBUS7 MT DTT DMNBUS7 RN Rozrolimupab, symphobodies against rhesus D, for the potential prevention of hemolytic disease of the newborn and the treatment of idiopathic thrombocytopenic purpura. Curr Opin Mol Ther. 2010 Dec;12(6):734-40. DMNBUS7 RU https://pubmed.ncbi.nlm.nih.gov/21154165 DMTQ3BS DI DMTQ3BS DMTQ3BS DN RP-64477 DMTQ3BS MI TTMF541 DMTQ3BS MN Liver carboxylesterase (CES1) DMTQ3BS MT DTT DMTQ3BS MA Modulator DMTQ3BS RN RP 64477: a potent inhibitor of acyl-coenzyme A:cholesterol O-acyltransferase with low systemic bioavailability. Biochem Pharmacol. 1996 Feb 23;51(4):413-21. DMTQ3BS RU https://pubmed.ncbi.nlm.nih.gov/8619885 DMRGC5B DI DMRGC5B DMRGC5B DN RPR-106541 DMRGC5B MI TTPNQAC DMRGC5B MN Estrogen-related receptor-alpha (ESRRA) DMRGC5B MT DTT DMRGC5B MA Agonist DMRGC5B RN Use of the steroid derivative RPR 106541 in combination with site-directed mutagenesis for enhanced cytochrome P-450 3A4 structure/function analysis. J Pharmacol Exp Ther. 1999 Aug;290(2):594-602. DMRGC5B RU https://pubmed.ncbi.nlm.nih.gov/10411567 DM4GVZ9 DI DM4GVZ9 DM4GVZ9 DN RQ-00317076 DM4GVZ9 MI TTVKILB DM4GVZ9 MN Prostaglandin G/H synthase 2 (COX-2) DM4GVZ9 MT DTT DM4GVZ9 MA Inhibitor DM4GVZ9 RN Clinical pipeline report, company report or official report of raqualia. DM4GVZ9 RU http://www.raqualia.com/rq-cms/wp-content/uploads/2012/03/240313_Mid-Term-Business-Plan_final.pdf DMOTANY DI DMOTANY DMOTANY DN RS-130830 DMOTANY MI TTMX39J DMOTANY MN Matrix metalloproteinase-1 (MMP-1) DMOTANY MT DTT DMOTANY MA Inhibitor DMOTANY RN Structure-based design of potent and selective inhibitors of collagenase-3 (MMP-13). Bioorg Med Chem Lett. 2005 Feb 15;15(4):1101-6. DMOTANY RU https://pubmed.ncbi.nlm.nih.gov/15686921 DMOTANY DI DMOTANY DMOTANY DN RS-130830 DMOTANY MI TTHY57M DMOTANY MN Matrix metalloproteinase-13 (MMP-13) DMOTANY MT DTT DMOTANY MA Inhibitor DMOTANY RN Structure-based design of potent and selective inhibitors of collagenase-3 (MMP-13). Bioorg Med Chem Lett. 2005 Feb 15;15(4):1101-6. DMOTANY RU https://pubmed.ncbi.nlm.nih.gov/15686921 DMOTANY DI DMOTANY DMOTANY DN RS-130830 DMOTANY MI TTLM12X DMOTANY MN Matrix metalloproteinase-2 (MMP-2) DMOTANY MT DTT DMOTANY MA Inhibitor DMOTANY RN Structure-based design of potent and selective inhibitors of collagenase-3 (MMP-13). Bioorg Med Chem Lett. 2005 Feb 15;15(4):1101-6. DMOTANY RU https://pubmed.ncbi.nlm.nih.gov/15686921 DMOTANY DI DMOTANY DMOTANY DN RS-130830 DMOTANY MI TTUZ2L5 DMOTANY MN Matrix metalloproteinase-3 (MMP-3) DMOTANY MT DTT DMOTANY MA Inhibitor DMOTANY RN Structure-based design of potent and selective inhibitors of collagenase-3 (MMP-13). Bioorg Med Chem Lett. 2005 Feb 15;15(4):1101-6. DMOTANY RU https://pubmed.ncbi.nlm.nih.gov/15686921 DMOTANY DI DMOTANY DMOTANY DN RS-130830 DMOTANY MI TT6X50U DMOTANY MN Matrix metalloproteinase-9 (MMP-9) DMOTANY MT DTT DMOTANY MA Inhibitor DMOTANY RN Structure-based design of potent and selective inhibitors of collagenase-3 (MMP-13). Bioorg Med Chem Lett. 2005 Feb 15;15(4):1101-6. DMOTANY RU https://pubmed.ncbi.nlm.nih.gov/15686921 DMERM0K DI DMERM0K DMERM0K DN RS-8359 DMERM0K MI DE4LYSA DMERM0K MN Cytochrome P450 3A4 (CYP3A4) DMERM0K MT DME DMERM0K MA Metabolism DMERM0K RN Stereoselective pharmacokinetics of RS-8359, a selective and reversible MAO-A inhibitor, by species-dependent drug-metabolizing enzymes. Chirality. 2005 Mar;17(3):135-41. DMERM0K RU https://www.ncbi.nlm.nih.gov/pubmed/?term=15704197 DMERM0K DI DMERM0K DMERM0K DN RS-8359 DMERM0K MI TT3WG5C DMERM0K MN Monoamine oxidase type A (MAO-A) DMERM0K MT DTT DMERM0K MA Inhibitor DMERM0K RN Stereospecific oxidation of the (S)-enantiomer of RS-8359, a selective and reversible monoamine oxidase A (MAO-A) inhibitor, by aldehyde oxidase. Xenobiotica. 2005 Jun;35(6):561-73. DMERM0K RU https://pubmed.ncbi.nlm.nih.gov/16192108 DMIKUXN DI DMIKUXN DMIKUXN DN RSD-921 DMIKUXN MI TTRK8B9 DMIKUXN MN Sodium channel unspecific (NaC) DMIKUXN MT DTT DMIKUXN MA Modulator DMIKUXN RN Molecular analysis of the Na+ channel blocking actions of the novel class I anti-arrhythmic agent RSD 921. Br J Pharmacol. 1999 May;127(1):9-18. DMIKUXN RU https://pubmed.ncbi.nlm.nih.gov/10369450 DMPAH74 DI DMPAH74 DMPAH74 DN R-sibutramine metabolite DMPAH74 MI TTAWNKZ DMPAH74 MN Norepinephrine transporter (NET) DMPAH74 MT DTT DMPAH74 MA Modulator DMPAH74 RN Monoamine reuptake site occupancy of sibutramine: Relationship to antidepressant-like and thermogenic effects in rats.Eur J Pharmacol.2014 Aug 15;737:47-56. DMPAH74 RU https://www.ncbi.nlm.nih.gov/pubmed/24821570 DMPAH74 DI DMPAH74 DMPAH74 DN R-sibutramine metabolite DMPAH74 MI TT3ROYC DMPAH74 MN Serotonin transporter (SERT) DMPAH74 MT DTT DMPAH74 MA Modulator DMPAH74 RN Monoamine reuptake site occupancy of sibutramine: Relationship to antidepressant-like and thermogenic effects in rats.Eur J Pharmacol.2014 Aug 15;737:47-56. DMPAH74 RU https://www.ncbi.nlm.nih.gov/pubmed/24821570 DMR0K85 DI DMR0K85 DMR0K85 DN RX-77368 DMR0K85 MI TT2Z39D DMR0K85 MN Thyrotropin-releasing hormone (TRH) DMR0K85 MT DTT DMR0K85 MA Modulator DMR0K85 RN Intracisternal urocortin inhibits vagally stimulated gastric motility in rats: role of CRF(2).Br J Pharmacol.2002 May;136(2):237-47. DMR0K85 RU https://www.ncbi.nlm.nih.gov/pubmed/12010772 DMS6NAK DI DMS6NAK DMS6NAK DN S-12363 DMS6NAK MI TTYFKSZ DMS6NAK MN Tubulin beta (TUBB) DMS6NAK MT DTT DMS6NAK MA Modulator DMS6NAK RN Microtubule assembly protects the region 28-38 of the beta- tubulin subunit. Article first published online: 4 FEB 2005. DMS6NAK RU http://onlinelibrary.wiley.com/doi/10.1002/cm.970220104/abstract DMLCYX8 DI DMLCYX8 DMLCYX8 DN S-15261 DMLCYX8 MI TTZOPHG DMLCYX8 MN Insulin (INS) DMLCYX8 MT DTT DMLCYX8 MA Modulator DMLCYX8 RN Beneficial insulin-sensitizing and vascular effects of S15261 in the insulin-resistant JCR:LA-cp rat. J Pharmacol Exp Ther. 2000 Nov;295(2):753-60. DMLCYX8 RU https://pubmed.ncbi.nlm.nih.gov/11046115 DM51WJN DI DM51WJN DM51WJN DN S-16020-2 DM51WJN MI TTGTQHC DM51WJN MN DNA topoisomerase I (TOP1) DM51WJN MT DTT DM51WJN MA Modulator DM51WJN RN Cellular resistance to the antitumor DNA topoisomerase II inhibitor S16020-2: importance of the N-[2(Dimethylamino)ethyl]carbamoyl side chain. Mol Pharmacol. 2000 Oct;58(4):709-18. DM51WJN RU https://www.ncbi.nlm.nih.gov/pubmed/10999940 DMA01BV DI DMA01BV DMA01BV DN S-18986 DMA01BV MI TTAN6JD DMA01BV MN Glutamate receptor AMPA (GRIA) DMA01BV MT DTT DMA01BV MA Modulator DMA01BV RN Glutamate- and GABA-based CNS therapeutics. Curr Opin Pharmacol. 2006 Feb;6(1):7-17. DMA01BV RU https://pubmed.ncbi.nlm.nih.gov/16377242 DMMSZ1A DI DMMSZ1A DMMSZ1A DN S-2474 DMMSZ1A MI TTVKILB DMMSZ1A MN Prostaglandin G/H synthase 2 (COX-2) DMMSZ1A MT DTT DMMSZ1A MA Inhibitor DMMSZ1A RN Effects of S-2474, a novel nonsteroidal anti-inflammatory drug, on amyloid beta protein-induced neuronal cell death. Br J Pharmacol. 2001 Oct;134(3):673-81. DMMSZ1A RU https://pubmed.ncbi.nlm.nih.gov/11588123 DMQ2RDZ DI DMQ2RDZ DMQ2RDZ DN S-312-d DMQ2RDZ MI TT5HONZ DMQ2RDZ MN Calcium channel unspecific (CaC) DMQ2RDZ MT DTT DMQ2RDZ MA Blocker DMQ2RDZ RN Protective effects of a selective L-type voltage-sensitive calcium channel blocker, S-312-d, on neuronal cell death. Biochem Pharmacol. 2004 Mar 15;67(6):1153-65. DMQ2RDZ RU https://pubmed.ncbi.nlm.nih.gov/15006551 DM2X6ME DI DM2X6ME DM2X6ME DN S-5751 DM2X6ME MI TTNVEIR DM2X6ME MN Prostaglandin D2 receptor (PTGDR) DM2X6ME MT DTT DM2X6ME MA Antagonist DM2X6ME RN Therapeutic target database update 2012: a resource for facilitating target-oriented drug discovery. Nucleic Acids Res. 2012 Jan;40(Database issue):D1128-36. DM2X6ME RU https://pubmed.ncbi.nlm.nih.gov/21948793 DM9BEDL DI DM9BEDL DM9BEDL DN S-8510 DM9BEDL MI TTPTXIN DM9BEDL MN Translocator protein (TSPO) DM9BEDL MT DTT DM9BEDL MA Agonist DM9BEDL RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015 DM9BEDL RU https://www.accessdata.fda.gov/scripts/cder/drugsatfda/ DMER3I9 DI DMER3I9 DMER3I9 DN S-9788 DMER3I9 MI TTO32GK DMER3I9 MN P-glycoprotein (P-GP) DMER3I9 MT DTT DMER3I9 MA Modulator DMER3I9 RN In vitro activity of S 9788 on a multidrug-resistant leukemic cell line and on normal hematopoietic cells-reversal of multidrug resistance by sera from phase I-treated patients. Cancer Chemother Pharmacol. 1995;36(3):195-203. DMER3I9 RU https://pubmed.ncbi.nlm.nih.gov/7781138 DMER3I9 DI DMER3I9 DMER3I9 DN S-9788 DMER3I9 MI DTUGYRD DMER3I9 MN P-glycoprotein 1 (ABCB1) DMER3I9 MT DTP DMER3I9 MA Substrate DMER3I9 RN Human intestinal transporter database: QSAR modeling and virtual profiling of drug uptake, efflux and interactions. Pharm Res. 2013 Apr;30(4):996-1007. DMER3I9 RU https://doi.org/10.1007/s11095-012-0935-x DMEO6A5 DI DMEO6A5 DMEO6A5 DN S-9977 DMEO6A5 MI TT1RS9F DMEO6A5 MN Acetylcholinesterase (AChE) DMEO6A5 MT DTT DMEO6A5 MA Inhibitor DMEO6A5 RN Xanthine derivatives IBMX and S-9977-2 potentiate transmission at an Aplysia central cholinergic synapse. Brain Res. 1992 Jul 17;586(1):78-85. DMEO6A5 RU https://pubmed.ncbi.nlm.nih.gov/1380883 DMC57JU DI DMC57JU DMC57JU DN Saperconazole DMC57JU MI TT8YUAD DMC57JU MN P450-dependent ergosterol synthesis (PDE synth) DMC57JU MT DTT DMC57JU MA Modulator DMC57JU RN Saperconazole: a selective inhibitor of the cytochrome P-450-dependent ergosterol synthesis in Candida albicans, Aspergillus fumigatus and Trichophyton mentagrophytes. Mycoses. 1990 Jul-Aug;33(7-8):335-52. DMC57JU RU https://pubmed.ncbi.nlm.nih.gov/2090934 DMQMA17 DI DMQMA17 DMQMA17 DN SAVOXEPIN MESYLATE DMQMA17 MI TTEX248 DMQMA17 MN Dopamine D2 receptor (D2R) DMQMA17 MT DTT DMQMA17 MA Agonist DMQMA17 RN Savoxepine: striatal dopamine-D2 receptor occupancy in human volunteers measured using positron emission tomography (PET). Eur J Clin Pharmacol. 1993;44(2):135-40. DMQMA17 RU https://pubmed.ncbi.nlm.nih.gov/8095895 DMIF4VJ DI DMIF4VJ DMIF4VJ DN SB-201993 DMIF4VJ MI TTN53ZF DMIF4VJ MN Leukotriene B4 receptor 1 (LTB4R) DMIF4VJ MT DTT DMIF4VJ MA Inhibitor DMIF4VJ RN (E)-3-[6-[[(2,6-dichlorophenyl)thio]methyl]-3-(2-phenylethoxy)-2- pyridinyl]-2-propenoic acid: a high-affinity leukotriene B4 receptor antagonist w... J Med Chem. 1996 Sep 13;39(19):3837-41. DMIF4VJ RU https://pubmed.ncbi.nlm.nih.gov/8809171 DMJYW80 DI DMJYW80 DMJYW80 DN SB-209670 DMJYW80 MI TTKRD0G DMJYW80 MN Endothelin A receptor (EDNRA) DMJYW80 MT DTT DMJYW80 MA Modulator DMJYW80 RN Effects of the endothelin receptor antagonist, SB 209670, on circulatory failure and organ injury in endotoxic shock in the anaesthetized rat. Br J Pharmacol. 1996 May;118(1):198-204. DMJYW80 RU https://pubmed.ncbi.nlm.nih.gov/8733596 DMJYW80 DI DMJYW80 DMJYW80 DN SB-209670 DMJYW80 MI TT3ZTGU DMJYW80 MN Endothelin B receptor (EDNRB) DMJYW80 MT DTT DMJYW80 MA Modulator DMJYW80 RN Effects of the endothelin receptor antagonist, SB 209670, on circulatory failure and organ injury in endotoxic shock in the anaesthetized rat. Br J Pharmacol. 1996 May;118(1):198-204. DMJYW80 RU https://pubmed.ncbi.nlm.nih.gov/8733596 DMXFQS1 DI DMXFQS1 DMXFQS1 DN SB-756050 DMXFQS1 MI TTS4UGC DMXFQS1 MN Farnesoid X-activated receptor (FXR) DMXFQS1 MT DTT DMXFQS1 MA Agonist DMXFQS1 RN Clinical pipeline report, company report or official report of GlaxoSmithKline (2009). DMXFQS1 RU http://www.gsk.com/investors/product_pipeline/docs/gsk-pipeline-feb09.pdf DMTZ7E4 DI DMTZ7E4 DMTZ7E4 DN SC-106 DMTZ7E4 MI TT9V5JH DMTZ7E4 MN Phospholipase A2 (PLA2G1B) DMTZ7E4 MT DTT DMTZ7E4 MA Inhibitor DMTZ7E4 RN US patent application no. 6,673,908, Tumor necrosis factor receptor 2. DMTZ7E4 RU http://www.google.com/patents/US6673908 DMQ0T6L DI DMQ0T6L DMQ0T6L DN SC-45662 DMQ0T6L MI TT2J34L DMQ0T6L MN Arachidonate 5-lipoxygenase (5-LOX) DMQ0T6L MT DTT DMQ0T6L MA Inhibitor DMQ0T6L RN The immunosuppressive properties of enisoprost and a 5-lipoxygenase inhibitor (SC-45662). Transplantation. 1991 Dec;52(6):1053-7. DMQ0T6L RU https://pubmed.ncbi.nlm.nih.gov/1750068 DMAGBM2 DI DMAGBM2 DMAGBM2 DN SCH-32615 DMAGBM2 MI TT5TKPM DMAGBM2 MN Neutral endopeptidase (MME) DMAGBM2 MT DTT DMAGBM2 MA Inhibitor DMAGBM2 RN The antinociceptive effects of SCH-32615, a neutral endopeptidase (enkephalinase) inhibitor, microinjected into the periaqueductal, ventral medulla and amygdala. Brain Res. 1990 Jun 18;520(1-2):123-30. DMAGBM2 RU https://pubmed.ncbi.nlm.nih.gov/2207626 DMZR6GI DI DMZR6GI DMZR6GI DN Sch-34826 DMZR6GI MI TT5TKPM DMZR6GI MN Neutral endopeptidase (MME) DMZR6GI MT DTT DMZR6GI MA Modulator DMZR6GI RN Pharmacology of SCH 34826, an orally active enkephalinase inhibitor analgesic. J Pharmacol Exp Ther. 1988 Jun;245(3):829-38. DMZR6GI RU https://pubmed.ncbi.nlm.nih.gov/3164388 DM2RH51 DI DM2RH51 DM2RH51 DN SCH-42495 DM2RH51 MI TT5TKPM DM2RH51 MN Neutral endopeptidase (MME) DM2RH51 MT DTT DM2RH51 MA Inhibitor DM2RH51 RN Endopeptidase 24.11 inhibition by SCH 42495 in essential hypertension. Hypertension. 1993 Jul;22(1):119-26. DM2RH51 RU https://pubmed.ncbi.nlm.nih.gov/8391513 DM28AFU DI DM28AFU DM28AFU DN SCH-48461 DM28AFU MI TTNA5ZS DM28AFU MN Cholesterol absorption (Chole absorp) DM28AFU MT DTT DM28AFU MA Modulator DM28AFU RN Hypocholesterolemic activity of a novel inhibitor of cholesterol absorption, SCH 48461. Atherosclerosis. 1995 May;115(1):45-63. DM28AFU RU https://pubmed.ncbi.nlm.nih.gov/7669087 DMX4938 DI DMX4938 DMX4938 DN SDZ-LAP-977 DMX4938 MI TTJSQEF DMX4938 MN Tyrosine-protein kinase (PTK) DMX4938 MT DTT DMX4938 MA Inhibitor DMX4938 RN Structure-activity relationship studies on a novel class of antiproliferative agents derived from Lavendustin A. Part I: Ring A modifications. Bioorg Med Chem. 2008 Aug 15;16(16):7552-60. DMX4938 RU https://pubmed.ncbi.nlm.nih.gov/18678497 DMXZVPH DI DMXZVPH DMXZVPH DN SEGLITIDE DMXZVPH MI TTOMNR9 DMXZVPH MN Somatostatin receptor (SSTR) DMXZVPH MT DTT DMXZVPH MA Modulator DMXZVPH RN Antagonist effects of seglitide (MK 678) at somatostatin receptors in guinea-pig isolated right atria.. Br J Pharmacol. 1993 August; 109(4): 898-899. DMXZVPH RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2175736/ DMLK605 DI DMLK605 DMLK605 DN Semparatide DMLK605 MI TTEPJL5 DMLK605 MN Parathyroid hormone receptor (PTH2R) DMLK605 MT DTT DMLK605 MA Modulator DMLK605 RN Quantitative cell membrane-based radioligand binding assays for parathyroid hormone receptors. J Pharmacol Toxicol Methods. 1999 Apr-Jun;41(2-3):83-90. DMLK605 RU https://pubmed.ncbi.nlm.nih.gov/10598679 DM75ZO0 DI DM75ZO0 DM75ZO0 DN SERAZAPINE HYDROCHLORIDE DM75ZO0 MI TTJQOD7 DM75ZO0 MN 5-HT 2A receptor (HTR2A) DM75ZO0 MT DTT DM75ZO0 MA Antagonist DM75ZO0 RN Serotonergic (5-HT2) mediation of anxiety-therapeutic effects of serazepine in generalized anxiety disorder. Biol Psychiatry. 1993 Jul 1-15;34(1-2):41-4. DM75ZO0 RU https://pubmed.ncbi.nlm.nih.gov/8104044 DM9KB8A DI DM9KB8A DM9KB8A DN SERGOLEXOLE MALEATE DM9KB8A MI TTJQOD7 DM9KB8A MN 5-HT 2A receptor (HTR2A) DM9KB8A MT DTT DM9KB8A MA Antagonist DM9KB8A RN 5-Hydroxytryptamine2 receptor antagonist activity of the acid metabolite (1-isopropyl dihydrolysergic acid) of the ergoline ester, sergolexole (LY281067). J Pharmacol Exp Ther. 1989 Dec;251(3):1006-11. DM9KB8A RU https://pubmed.ncbi.nlm.nih.gov/2600800 DMSLP2O DI DMSLP2O DMSLP2O DN SERM-3339 DMSLP2O MI TTZAYWL DMSLP2O MN Estrogen receptor (ESR) DMSLP2O MT DTT DMSLP2O MA Modulator DMSLP2O RN CN patent application no. 102406650, Sex steroid precursors alone or in combination with selective estrogen receptor modulator for prevention and treatment of vaginal dryness and sexual dysfunction in postmenop. DMSLP2O RU http://www.google.com/patents/CN102406650A?cl=en DMBG6LP DI DMBG6LP DMBG6LP DN SGB-1534 DMBG6LP MI TT2NUT5 DMBG6LP MN Adrenergic receptor alpha-2C (ADRA2C) DMBG6LP MT DTT DMBG6LP MA Modulator DMBG6LP RN Potent alpha-adrenoceptor blocking action of SGB-1534, a new quinazoline antihypertensive agent in vitro experiments. Gen Pharmacol. 1986;17(2):143-9. DMBG6LP RU https://pubmed.ncbi.nlm.nih.gov/2870954 DM6XJ9D DI DM6XJ9D DM6XJ9D DN SGS-111 DM6XJ9D MI TT9IK2Z DM6XJ9D MN N-methyl-D-aspartate receptor (NMDAR) DM6XJ9D MT DTT DM6XJ9D MA Modulator DM6XJ9D RN Molecular basis of pharmacotherapies for cognition in Down syndrome. Trends Pharmacol Sci. 2010 February; 31(2): 66. DM6XJ9D RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2815198/ DM7XC0U DI DM7XC0U DM7XC0U DN SIB-1553A DM7XC0U MI TTTVAFQ DM7XC0U MN Neuronal acetylcholine receptor beta-4 (CHRNB4) DM7XC0U MT DTT DM7XC0U MA Agonist DM7XC0U RN SIB-1553A, (+/-)-4-[[2-(1-methyl-2-pyrrolidinyl)ethyl]thio]phenol hydrochloride, a subtype-selective ligand for nicotinic acetylcholine receptors with putative cognitive-enhancing properties: effectson working and reference memory performances in aged rodents and nonhuman primates. J Pharmacol Exp Ther. 2001 Oct;299(1):297-306. DM7XC0U RU https://pubmed.ncbi.nlm.nih.gov/11561092 DM7XC0U DI DM7XC0U DM7XC0U DN SIB-1553A DM7XC0U MI TTJSZTB DM7XC0U MN Nicotinic acetylcholine receptor (nAChR) DM7XC0U MT DTT DM7XC0U MA Agonist DM7XC0U RN The potential of subtype-selective neuronal nicotinic acetylcholine receptor agonists as therapeutic agents. Life Sci. 1998;62(17-18):1601-6. DM7XC0U RU https://pubmed.ncbi.nlm.nih.gov/9585143 DMY30G2 DI DMY30G2 DMY30G2 DN SILPERISONE HYDROCHLORIDE DMY30G2 MI TTRK8B9 DMY30G2 MN Sodium channel unspecific (NaC) DMY30G2 MT DTT DMY30G2 MA Modulator DMY30G2 RN Tolperisone-type drugs inhibit spinal reflexes via blockade of voltage-gated sodium and calcium channels. J Pharmacol Exp Ther. 2005 Dec;315(3):1237-46. DMY30G2 RU https://pubmed.ncbi.nlm.nih.gov/16126840 DMMZ2JT DI DMMZ2JT DMMZ2JT DN SINITRODIL DMMZ2JT MI TTJ0IQB DMMZ2JT MN Phosphodiesterase 5A (PDE5A) DMMZ2JT MT DTT DMMZ2JT MA Modulator DMMZ2JT RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015 DMMZ2JT RU https://www.accessdata.fda.gov/scripts/cder/drugsatfda/ DMYP3KI DI DMYP3KI DMYP3KI DN SINOMENINE DMYP3KI MI TTFQVUT DMYP3KI MN NADPH oxidase (NOX) DMYP3KI MT DTT DMYP3KI MA Modulator DMYP3KI RN Sinomenine, a natural dextrorotatory morphinan analog, is anti-inflammatory and neuroprotective through inhibition of microglial NADPH oxidase. J Neuroinflammation. 2007 Sep 19;4:23. DMYP3KI RU https://pubmed.ncbi.nlm.nih.gov/17880684 DMMQ4GC DI DMMQ4GC DMMQ4GC DN Sipatrigine DMMQ4GC MI TTRK8B9 DMMQ4GC MN Sodium channel unspecific (NaC) DMMQ4GC MT DTT DMMQ4GC MA Inhibitor DMMQ4GC RN Medicinal chemistry of neuronal voltage-gated sodium channel blockers. J Med Chem. 2001 Jan 18;44(2):115-37. DMMQ4GC RU https://pubmed.ncbi.nlm.nih.gov/11170622 DMMQ4GC DI DMMQ4GC DMMQ4GC DN Sipatrigine DMMQ4GC MI TT7RGTM DMMQ4GC MN Voltage-gated calcium channel alpha Cav1.3 (CACNA1D) DMMQ4GC MT DTT DMMQ4GC MA Inhibitor DMMQ4GC RN Synthesis and characterization of N-(acenaphth-5-yl)-N'-(4-methoxynaphth-1-yl)guanidine as a glutamate release inhibitor and potential anti-ischemic agent, Bioorg. Med. Chem. Lett. 5(19):2259-2262 (1995). DMMQ4GC RU http://www.sciencedirect.com/science/article/pii/0960894X95003927 DMMQ4GC DI DMMQ4GC DMMQ4GC DN Sipatrigine DMMQ4GC MI TTAXZ0K DMMQ4GC MN Voltage-gated sodium channel alpha Nav1.3 (SCN3A) DMMQ4GC MT DTT DMMQ4GC MA Inhibitor DMMQ4GC RN Synthesis and structure-activity relationships of 6,7-benzomorphan derivatives as use-dependent sodium channel blockers for the treatment of stroke. J Med Chem. 2002 Aug 15;45(17):3755-64. DMMQ4GC RU https://pubmed.ncbi.nlm.nih.gov/12166948 DMMQ4GC DI DMMQ4GC DMMQ4GC DN Sipatrigine DMMQ4GC MI TT84DRB DMMQ4GC MN Voltage-gated sodium channel alpha Nav1.4 (SCN4A) DMMQ4GC MT DTT DMMQ4GC MA Inhibitor DMMQ4GC RN Oxadiazolylindazole sodium channel modulators are neuroprotective toward hippocampal neurones. J Med Chem. 2009 May 14;52(9):2694-707. DMMQ4GC RU https://pubmed.ncbi.nlm.nih.gov/19341281 DMMQ4GC DI DMMQ4GC DMMQ4GC DN Sipatrigine DMMQ4GC MI TTZOVE0 DMMQ4GC MN Voltage-gated sodium channel alpha Nav1.5 (SCN5A) DMMQ4GC MT DTT DMMQ4GC MA Inhibitor DMMQ4GC RN Medicinal chemistry of neuronal voltage-gated sodium channel blockers. J Med Chem. 2001 Jan 18;44(2):115-37. DMMQ4GC RU https://pubmed.ncbi.nlm.nih.gov/11170622 DMMQ4GC DI DMMQ4GC DMMQ4GC DN Sipatrigine DMMQ4GC MI TT4G2JS DMMQ4GC MN Voltage-gated sodium channel alpha Nav1.7 (SCN9A) DMMQ4GC MT DTT DMMQ4GC MA Inhibitor DMMQ4GC RN Oxadiazolylindazole sodium channel modulators are neuroprotective toward hippocampal neurones. J Med Chem. 2009 May 14;52(9):2694-707. DMMQ4GC RU https://pubmed.ncbi.nlm.nih.gov/19341281 DMMQ4GC DI DMMQ4GC DMMQ4GC DN Sipatrigine DMMQ4GC MI TT90XZ8 DMMQ4GC MN Voltage-gated sodium channel alpha Nav1.8 (SCN10A) DMMQ4GC MT DTT DMMQ4GC MA Inhibitor DMMQ4GC RN Oxadiazolylindazole sodium channel modulators are neuroprotective toward hippocampal neurones. J Med Chem. 2009 May 14;52(9):2694-707. DMMQ4GC RU https://pubmed.ncbi.nlm.nih.gov/19341281 DM2BDAW DI DM2BDAW DM2BDAW DN SK&F-S-106203 DM2BDAW MI TTTWGIX DM2BDAW MN Leukotriene receptor (LTR) DM2BDAW MT DTT DM2BDAW MA Modulator DM2BDAW RN Pharmacologic and pharmacokinetic profile of SK&F S-106203, a potent, orally active peptidoleukotriene receptor antagonist, in guinea-pig. Pulm Pharmacol. 1991;4(3):177-89. DM2BDAW RU https://pubmed.ncbi.nlm.nih.gov/1668219 DM40HTZ DI DM40HTZ DM40HTZ DN SKF-97426 DM40HTZ MI TTS4UGC DM40HTZ MN Farnesoid X-activated receptor (FXR) DM40HTZ MT DTT DM40HTZ MA Modulator DM40HTZ RN SK&F 97426-A a more potent bile acid sequestrant and hypocholesterolaemic agent than cholestyramine in the hamster. Atherosclerosis. 1993 Jun;101(1):51-60. DM40HTZ RU https://pubmed.ncbi.nlm.nih.gov/8216502 DME1JYP DI DME1JYP DME1JYP DN SL-25.1039 DME1JYP MI TT34BHT DME1JYP MN Adrenergic receptor alpha-1D (ADRA1D) DME1JYP MT DTT DME1JYP MA Agonist DME1JYP RN Pharmaceutical co analysis sanofi aventis, 2006, Page(216). DME1JYP RU http://www.alacrastore.com/storecontent/Thomson-Reuters-Market-Research/PHARMACEUTICAL-CO-ANALYSIS-SANOFI-AVENTIS-ESPICOM-HEALTHCARE-INTELLIGENCE-50201119 DMAM9BD DI DMAM9BD DMAM9BD DN SL65.0155 DMAM9BD MI TT07C3Y DMAM9BD MN 5-HT 4 receptor (HTR4) DMAM9BD MT DTT DMAM9BD MA Agonist DMAM9BD RN SL65.0155, a novel 5-hydroxytryptamine(4) receptor partial agonist with potent cognition-enhancing properties. J Pharmacol Exp Ther. 2002 Aug;302(2):731-41. DMAM9BD RU https://pubmed.ncbi.nlm.nih.gov/12130738 DMU5RKC DI DMU5RKC DMU5RKC DN SL65.0472 DMU5RKC MI TTJQOD7 DMU5RKC MN 5-HT 2A receptor (HTR2A) DMU5RKC MT DTT DMU5RKC MA Modulator DMU5RKC RN Antiplatelet and antithrombotic activity of SL65.0472, a mixed 5-HT1B/5-HT2A receptor antagonist.Thromb Haemost.2001 Mar;85(3):521-8. DMU5RKC RU https://www.ncbi.nlm.nih.gov/pubmed/11307825 DMS8AHE DI DMS8AHE DMS8AHE DN SL-65.1498 DMS8AHE MI TTEX6LM DMS8AHE MN GABA(A) receptor gamma-3 (GABRG3) DMS8AHE MT DTT DMS8AHE MA Agonist DMS8AHE RN WO patent application no. 2005,0749,31, Pharmaceutical combinations comprising (s) -pantoprazole. DMS8AHE RU http://worldwide.espacenet.com/publicationDetails/biblio?DB=worldwide.espacenet.com&II=0&ND=3&adjacent=true&locale=en_EP&FT=D&date=20050818&CC=WO&NR=2005074931A1&KC=A1 DMOXUEP DI DMOXUEP DMOXUEP DN SL-89.0591 DMOXUEP MI TT34BHT DMOXUEP MN Adrenergic receptor alpha-1D (ADRA1D) DMOXUEP MT DTT DMOXUEP MA Modulator DMOXUEP RN Effects of alpha1-adrenoceptor antagonists on agonist and tilt-induced changes in blood pressure: relationships to uroselectivity. Eur J Pharmacol. 1999 May 28;373(1):51-62. DMOXUEP RU https://pubmed.ncbi.nlm.nih.gov/10408251 DMBZM0D DI DMBZM0D DMBZM0D DN SLV-305 DMBZM0D MI TT953CX DMBZM0D MN Motilin receptor (MLNR) DMBZM0D MT DTT DMBZM0D MA Modulator DMBZM0D RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 297). DMBZM0D RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=297 DM71WGZ DI DM71WGZ DM71WGZ DN SLV-310 DM71WGZ MI TTEX248 DM71WGZ MN Dopamine D2 receptor (D2R) DM71WGZ MT DTT DM71WGZ MA Modulator DM71WGZ RN SLV310, a novel, potential antipsychotic, combining potent dopamine D2 receptor antagonism with serotonin reuptake inhibition. Bioorg Med Chem Lett. 2003 Feb 10;13(3):405-8. DM71WGZ RU https://www.ncbi.nlm.nih.gov/pubmed/12565939 DM0GKHX DI DM0GKHX DM0GKHX DN SLV319 DM0GKHX MI TT6OEDT DM0GKHX MN Cannabinoid receptor 1 (CB1) DM0GKHX MT DTT DM0GKHX MA Antagonist DM0GKHX RN JD-5006 and JD-5037: peripherally restricted (PR) cannabinoid-1 receptor blockers related to SLV-319 (Ibipinabant) as metabolic disorder therapeutics devoid of CNS liabilities. Bioorg Med Chem Lett. 2012 Oct 1;22(19):6173-80. DM0GKHX RU https://pubmed.ncbi.nlm.nih.gov/22959249 DM1J0YB DI DM1J0YB DM1J0YB DN SLX-2101 DM1J0YB MI TTJ0IQB DM1J0YB MN Phosphodiesterase 5A (PDE5A) DM1J0YB MT DTT DM1J0YB MA Inhibitor DM1J0YB RN Novel phosphodiesterase-5 (PDE5) inhibitors in the alleviation of erectile dysfunction due to diabetes and ageing-induced oxidative stress. Expert Opin Investig Drugs. 2008 Jun;17(6):855-64. DM1J0YB RU https://pubmed.ncbi.nlm.nih.gov/18491987 DMZYGW0 DI DMZYGW0 DMZYGW0 DN SM-10661 DMZYGW0 MI TTQL5VC DMZYGW0 MN Platelet-activating factor receptor (PTAFR) DMZYGW0 MT DTT DMZYGW0 MA Antagonist DMZYGW0 RN Effect of the PAF-receptor antagonist SM-12502 on human platelets. Inflammation. 1996 Feb;20(1):71-85. DMZYGW0 RU https://pubmed.ncbi.nlm.nih.gov/8926050 DMBUH7E DI DMBUH7E DMBUH7E DN SM-10888 DMBUH7E MI TT1RS9F DMBUH7E MN Acetylcholinesterase (AChE) DMBUH7E MT DTT DMBUH7E MA Inhibitor DMBUH7E RN Pharmacological and biochemical assessment of SM-10888, a novel cholinesterase inhibitor. Jpn J Pharmacol. 1990 Jun;53(2):145-55. DMBUH7E RU https://pubmed.ncbi.nlm.nih.gov/2385001 DMJ816F DI DMJ816F DMJ816F DN Sodelglitazar DMJ816F MI TTJ584C DMJ816F MN Peroxisome proliferator-activated receptor alpha (PPARA) DMJ816F MT DTT DMJ816F MA Agonist DMJ816F RN Docking and molecular dynamics simulations of peroxisome proliferator activated receptors interacting with pan agonist sodelglitazar. Protein Pept Lett. 2011 Oct;18(10):1021-7. DMJ816F RU https://pubmed.ncbi.nlm.nih.gov/21592078 DMJ816F DI DMJ816F DMJ816F DN Sodelglitazar DMJ816F MI TT2JWF6 DMJ816F MN Peroxisome proliferator-activated receptor delta (PPARD) DMJ816F MT DTT DMJ816F MA Agonist DMJ816F RN Docking and molecular dynamics simulations of peroxisome proliferator activated receptors interacting with pan agonist sodelglitazar. Protein Pept Lett. 2011 Oct;18(10):1021-7. DMJ816F RU https://pubmed.ncbi.nlm.nih.gov/21592078 DMJ816F DI DMJ816F DMJ816F DN Sodelglitazar DMJ816F MI TTZMAO3 DMJ816F MN Peroxisome proliferator-activated receptor gamma (PPAR-gamma) DMJ816F MT DTT DMJ816F MA Agonist DMJ816F RN Docking and molecular dynamics simulations of peroxisome proliferator activated receptors interacting with pan agonist sodelglitazar. Protein Pept Lett. 2011 Oct;18(10):1021-7. DMJ816F RU https://pubmed.ncbi.nlm.nih.gov/21592078 DMHITR4 DI DMHITR4 DMHITR4 DN SOLPECAINOL HYDROCHLORIDE DMHITR4 MI TTRK8B9 DMHITR4 MN Sodium channel unspecific (NaC) DMHITR4 MT DTT DMHITR4 MA Modulator DMHITR4 RN US patent application no. 2002,0102,217, Diagnostic,therapeutic agents. DMHITR4 RU http://www.google.com.na/patents/US20020102217 DMCS8FM DI DMCS8FM DMCS8FM DN SORAPRAZAN DMCS8FM MI TTLOKXP DMCS8FM MN Gastric H(+)/K(+) ATPase (Proton pump) DMCS8FM MT DTT DMCS8FM MA Modulator DMCS8FM RN Soraprazan: setting new standards in inhibition of gastric acid secretion.J Pharmacol Exp Ther.2007 Jun;321(3):866-74. DMCS8FM RU https://www.ncbi.nlm.nih.gov/pubmed/17369284 DMPAEK5 DI DMPAEK5 DMPAEK5 DN SOU-001 DMPAEK5 MI TTNGILX DMPAEK5 MN Adrenergic receptor alpha-1A (ADRA1A) DMPAEK5 MT DTT DMPAEK5 MA Modulator DMPAEK5 RN Drug repositioning: identifying and developing new uses for existing drugs. Nat Rev Drug Discov. 2004 Aug;3(8):673-83. DMPAEK5 RU https://pubmed.ncbi.nlm.nih.gov/15286734 DMPAEK5 DI DMPAEK5 DMPAEK5 DN SOU-001 DMPAEK5 MI TTBRKXS DMPAEK5 MN Adrenergic receptor alpha-1B (ADRA1B) DMPAEK5 MT DTT DMPAEK5 MA Modulator DMPAEK5 RN Drug repositioning: identifying and developing new uses for existing drugs. Nat Rev Drug Discov. 2004 Aug;3(8):673-83. DMPAEK5 RU https://pubmed.ncbi.nlm.nih.gov/15286734 DMPAEK5 DI DMPAEK5 DMPAEK5 DN SOU-001 DMPAEK5 MI TT34BHT DMPAEK5 MN Adrenergic receptor alpha-1D (ADRA1D) DMPAEK5 MT DTT DMPAEK5 MA Modulator DMPAEK5 RN Drug repositioning: identifying and developing new uses for existing drugs. Nat Rev Drug Discov. 2004 Aug;3(8):673-83. DMPAEK5 RU https://pubmed.ncbi.nlm.nih.gov/15286734 DMTJNRL DI DMTJNRL DMTJNRL DN SPD-473 DMTJNRL MI TTVBI8W DMTJNRL MN Dopamine transporter (DAT) DMTJNRL MT DTT DMTJNRL MA Inhibitor DMTJNRL RN Dopamine uptake inhibitor-induced rotation in 6-hydroxydopamine-lesioned rats involves both D1 and D2 receptors but is modulated through 5-hydroxyt... J Pharmacol Exp Ther. 2005 Mar;312(3):1124-31. DMTJNRL RU https://pubmed.ncbi.nlm.nih.gov/15542624 DMTJNRL DI DMTJNRL DMTJNRL DN SPD-473 DMTJNRL MI TTAWNKZ DMTJNRL MN Norepinephrine transporter (NET) DMTJNRL MT DTT DMTJNRL MA Inhibitor DMTJNRL RN Dopamine uptake inhibitor-induced rotation in 6-hydroxydopamine-lesioned rats involves both D1 and D2 receptors but is modulated through 5-hydroxyt... J Pharmacol Exp Ther. 2005 Mar;312(3):1124-31. DMTJNRL RU https://pubmed.ncbi.nlm.nih.gov/15542624 DMTJNRL DI DMTJNRL DMTJNRL DN SPD-473 DMTJNRL MI TT3ROYC DMTJNRL MN Serotonin transporter (SERT) DMTJNRL MT DTT DMTJNRL MA Inhibitor DMTJNRL RN Dopamine uptake inhibitor-induced rotation in 6-hydroxydopamine-lesioned rats involves both D1 and D2 receptors but is modulated through 5-hydroxyt... J Pharmacol Exp Ther. 2005 Mar;312(3):1124-31. DMTJNRL RU https://pubmed.ncbi.nlm.nih.gov/15542624 DMTC4VY DI DMTC4VY DMTC4VY DN SQ-30741 DMTC4VY MI TT2O84V DMTC4VY MN Thromboxane A2 receptor (TBXA2R) DMTC4VY MT DTT DMTC4VY MA Antagonist DMTC4VY RN Influence of SQ 30741 on thromboxane receptor-mediated responses in the feline pulmonary vascular bed. J Appl Physiol (1985). 1991 Nov;71(5):2012-8. DMTC4VY RU https://pubmed.ncbi.nlm.nih.gov/1837015 DMSQRXW DI DMSQRXW DMSQRXW DN SQ-32709 DMSQRXW MI DEFNVD7 DMSQRXW MN Ras proteins prenyltransferase alpha (FNTA) DMSQRXW MT DME DMSQRXW MA Metabolism DMSQRXW RN Site-selective enzymatic labeling of designed ankyrin repeat proteins using protein farnesyltransferase. Methods Mol Biol. 2019;2033:207-219. DMSQRXW RU https://www.ncbi.nlm.nih.gov/pubmed/?term=31332756 DMSQRXW DI DMSQRXW DMSQRXW DN SQ-32709 DMSQRXW MI DEIDTHQ DMSQRXW MN Squalene synthase (FDFT1) DMSQRXW MT DME DMSQRXW MA Metabolism DMSQRXW RN Increased activity of the sterol branch of the mevalonate pathway elevates glycosylation of secretory proteins and improves antifungal properties of Trichoderma atroviride. Fungal Genet Biol. 2020 Jan 17;137:103334. DMSQRXW RU https://www.ncbi.nlm.nih.gov/pubmed/?term=31958566 DMSQRXW DI DMSQRXW DMSQRXW DN SQ-32709 DMSQRXW MI TTFQEO5 DMSQRXW MN Squalene synthetase (FDFT1) DMSQRXW MT DTT DMSQRXW MA Modulator DMSQRXW RN Clinical pharmacokinetics and pharmacodynamics of a new squalene synthase inhibitor, BMS-188494, in healthy volunteers. J Clin Pharmacol. 1998 Dec;38(12):1116-21. DMSQRXW RU https://pubmed.ncbi.nlm.nih.gov/11301563 DMCEQKG DI DMCEQKG DMCEQKG DN SR-121787 DMCEQKG MI TT38RM1 DMCEQKG MN Glycoprotein IIb/IIIa receptor (GPIIb/IIIa) DMCEQKG MT DTT DMCEQKG MA Modulator DMCEQKG RN Prevention of thrombosis and enhancement of thrombolysis in rabbits by SR 121787, a glycoprotein II/III antagonist. J Pharmacol Exp Ther. 1998 Aug;286(2):670-5. DMCEQKG RU https://www.ncbi.nlm.nih.gov/pubmed/9694919 DMV4FT2 DI DMV4FT2 DMV4FT2 DN SR-57227 DMV4FT2 MI TTNXLKE DMV4FT2 MN 5-HT 3 receptor (5HT3R) DMV4FT2 MT DTT DMV4FT2 MA Modulator DMV4FT2 RN Antidepressant-like effects of SR 57227A, a 5-HT3 receptor agonist, in rodents. J Neural Transm Gen Sect. 1995;102(2):83-90. DMV4FT2 RU https://pubmed.ncbi.nlm.nih.gov/8748673 DMROKDM DI DMROKDM DMROKDM DN SR-90067 DMROKDM MI TTZAYWL DMROKDM MN Estrogen receptor (ESR) DMROKDM MT DTT DMROKDM MA Agonist DMROKDM RN US patent application no. 2010,0278,784, Methods and compositions for treating skin conditions. DMROKDM RU https://www.google.com.ar/patents/US20100278784 DMRKE9G DI DMRKE9G DMRKE9G DN SRI-62-834 DMRKE9G MI TT8FYO9 DMRKE9G MN Platelet-derived growth factor receptor alpha (PDGFRA) DMRKE9G MT DTT DMRKE9G MA Inhibitor DMRKE9G RN Antitumor activity of SRI 62-834, a cyclic ether analog of ET-18-OCH3. Lipids. 1987 Nov;22(11):884-90. DMRKE9G RU https://pubmed.ncbi.nlm.nih.gov/2832680 DMRKE9G DI DMRKE9G DMRKE9G DN SRI-62-834 DMRKE9G MI TTI7421 DMRKE9G MN Platelet-derived growth factor receptor beta (PDGFRB) DMRKE9G MT DTT DMRKE9G MA Inhibitor DMRKE9G RN Therapeutic target database update 2012: a resource for facilitating target-oriented drug discovery. Nucleic Acids Res. 2012 Jan;40(Database issue):D1128-36. DMRKE9G RU https://pubmed.ncbi.nlm.nih.gov/21948793 DMN7BM3 DI DMN7BM3 DMN7BM3 DN SSR-182289 DMN7BM3 MI TT6L509 DMN7BM3 MN Coagulation factor IIa (F2) DMN7BM3 MT DTT DMN7BM3 MA Inhibitor DMN7BM3 RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015 DMN7BM3 RU https://www.accessdata.fda.gov/scripts/cder/drugsatfda/ DMNRW68 DI DMNRW68 DMNRW68 DN SU-14813 DMNRW68 MI TTUTJGQ DMNRW68 MN Vascular endothelial growth factor receptor 2 (KDR) DMNRW68 MT DTT DMNRW68 MA Inhibitor DMNRW68 RN A comparison of physicochemical property profiles of marketed oral drugs and orally bioavailable anti-cancer protein kinase inhibitors in clinical development. Curr Top Med Chem. 2007;7(14):1408-22. DMNRW68 RU https://pubmed.ncbi.nlm.nih.gov/17692029 DMBSLZV DI DMBSLZV DMBSLZV DN Sulukast DMBSLZV MI TTGKOY9 DMBSLZV MN Leukotriene CysLT1 receptor (CYSLTR1) DMBSLZV MT DTT DMBSLZV MA Modulator DMBSLZV RN The pharmacological evaluation of LY 170680, a novel leukotriene D4 and E4 antagonist in the guinea-pig. Br J Pharmacol. 1989 Sep;98(1):259-67. DMBSLZV RU https://www.ncbi.nlm.nih.gov/pubmed/2553189 DMBSLZV DI DMBSLZV DMBSLZV DN Sulukast DMBSLZV MI TT0PZR5 DMBSLZV MN Leukotriene CysLT2 receptor (CYSLTR2) DMBSLZV MT DTT DMBSLZV MA Modulator DMBSLZV RN The pharmacological evaluation of LY 170680, a novel leukotriene D4 and E4 antagonist in the guinea-pig. Br J Pharmacol. 1989 Sep;98(1):259-67. DMBSLZV RU https://www.ncbi.nlm.nih.gov/pubmed/2553189 DMWTLQ4 DI DMWTLQ4 DMWTLQ4 DN SUN-1334H DMWTLQ4 MI TTTIBOJ DMWTLQ4 MN Histamine H1 receptor (H1R) DMWTLQ4 MT DTT DMWTLQ4 MA Antagonist DMWTLQ4 RN Preclinical efficacy and safety pharmacology of SUN-1334H, a potent orally active antihistamine agent. Drugs R D. 2008;9(2):93-112. DMWTLQ4 RU https://pubmed.ncbi.nlm.nih.gov/18298128 DMZ8VI0 DI DMZ8VI0 DMZ8VI0 DN SUN-C5174 DMZ8VI0 MI TTYSN63 DMZ8VI0 MN 5-HT 2 receptor (5HT2R) DMZ8VI0 MT DTT DMZ8VI0 MA Antagonist DMZ8VI0 RN Synthesis and serotonin 2 (5-HT2) receptor antagonist activity of 5-aminoalkyl-substituted pyrrolo[3,2-c]azepines and related compounds. Chem Pharm Bull (Tokyo). 2000 May;48(5):623-35. DMZ8VI0 RU https://pubmed.ncbi.nlm.nih.gov/10823697 DM19Y0T DI DM19Y0T DM19Y0T DN SUPER-LEU-DOX DM19Y0T MI TT0IHXV DM19Y0T MN DNA topoisomerase II (TOP2) DM19Y0T MT DTT DM19Y0T MA Modulator DM19Y0T RN Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41. DM19Y0T RU https://www.ncbi.nlm.nih.gov/pubmed/15950434 DMDZ7AY DI DMDZ7AY DMDZ7AY DN Suritozole DMDZ7AY MI TTEX6LM DMDZ7AY MN GABA(A) receptor gamma-3 (GABRG3) DMDZ7AY MT DTT DMDZ7AY MA Modulator DMDZ7AY RN Chronic postinjury administration of MDL 26,479 (Suritozole), a negative modulator at the GABAA receptor, and cognitive impairment in rats following traumatic brain injury. J Neurosurg. 1995 Nov;83(5):878-83. DMDZ7AY RU https://pubmed.ncbi.nlm.nih.gov/7472558 DMGFS51 DI DMGFS51 DMGFS51 DN T-1095 DMGFS51 MI TT2UE56 DMGFS51 MN Sodium/glucose cotransporter 1 (SGLT1) DMGFS51 MT DTT DMGFS51 MA Modulator DMGFS51 RN T-1095, an inhibitor of renal Na+-glucose cotransporters, may provide a novel approach to treating diabetes. Diabetes. 1999 Sep;48(9):1794-800. DMGFS51 RU https://pubmed.ncbi.nlm.nih.gov/10480610 DMZTL7H DI DMZTL7H DMZTL7H DN T487 DMZTL7H MI TT1UCIJ DMZTL7H MN C-X-C chemokine receptor type 3 (CXCR3) DMZTL7H MT DTT DMZTL7H MA Antagonist DMZTL7H RN Pharmacological characterization of CXC chemokine receptor 3 ligands and a small molecule antagonist. J Pharmacol Exp Ther. 2005 Jun;313(3):1263-71. DMZTL7H RU https://pubmed.ncbi.nlm.nih.gov/15761110 DM7XGJY DI DM7XGJY DM7XGJY DN T-506 DM7XGJY MI TTFH2RS DM7XGJY MN FK506-binding protein (FKBP) DM7XGJY MT DTT DM7XGJY MA Modulator DM7XGJY RN EP patent application no. 0831812, Methods and compositions for stimulating neurite growth. DM7XGJY RU https://www.google.com/patents/EP0831812A2?cl=en DMD3CUJ DI DMD3CUJ DMD3CUJ DN T-5224 DMD3CUJ MI TTN3GBV DMD3CUJ MN Transcription factor AP-1 (JUN) DMD3CUJ MT DTT DMD3CUJ MA Inhibitor DMD3CUJ RN CenterWatch. Drugs in Clinical Trials Database. CenterWatch. 2008. DMD3CUJ RU http://www.centerwatch.com/ DM3M5TU DI DM3M5TU DM3M5TU DN T-588 DM3M5TU MI TTV8KWS DM3M5TU MN Vesicular acetylcholine transporter (SLC18A3) DM3M5TU MT DTT DM3M5TU MA Modulator DM3M5TU RN Involvement of noradrenaline transporters in S-nitrosocysteine-stimulated noradrenaline release from rat brain slices: existence of functional Na(+)-independent transporter activity. Neurochem Int. 2001 Apr;38(4):323-31. DM3M5TU RU https://pubmed.ncbi.nlm.nih.gov/11137627 DMDN3TV DI DMDN3TV DMDN3TV DN T611 DMDN3TV MI TT01UPE DMDN3TV MN Cytomegalovirus Replication (CMV replication) DMDN3TV MT DTT DMDN3TV MA Inhibitor DMDN3TV RN A Systematic Screen for CDK4/6 Substrates Links FOXM1 Phosphorylation to Senescence Suppression in Cancer Cells. Cancer Cell. 2011 November 15; 20(5): 620-634. 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DMB3W20 RU http://care.diabetesjournals.org/content/30/6/1344.full DM1Z74X DI DM1Z74X DM1Z74X DN Tacedinaline DM1Z74X MI TT6R7JZ DM1Z74X MN Histone deacetylase 1 (HDAC1) DM1Z74X MT DTT DM1Z74X MA Inhibitor DM1Z74X RN Histone deacetylase inhibitors in cancer therapy: latest developments, trends and medicinal chemistry perspective. Anticancer Agents Med Chem. 2007 Sep;7(5):576-92. DM1Z74X RU https://pubmed.ncbi.nlm.nih.gov/17896917 DM0TDZI DI DM0TDZI DM0TDZI DN TAK-013 DM0TDZI MI TT8R70G DM0TDZI MN Gonadotropin-releasing hormone receptor (GNRHR) DM0TDZI MT DTT DM0TDZI MA Inhibitor DM0TDZI RN Non-peptide gonadotropin-releasing hormone receptor antagonists. J Med Chem. 2008 Jun 26;51(12):3331-48. DM0TDZI RU https://pubmed.ncbi.nlm.nih.gov/18419112 DMBQ87R DI DMBQ87R DMBQ87R DN TAK-044 DMBQ87R MI TTCV6O0 DMBQ87R MN Endothelin receptor (EDNR) DMBQ87R MT DTT DMBQ87R MA Modulator DMBQ87R RN Pharmacology of a non-selective ETA and ETB receptor antagonist, TAK-044 and the inhibition of myocardial infarct size in rats. Br J Pharmacol. 1995 Mar;114(5):949-54. DMBQ87R RU https://pubmed.ncbi.nlm.nih.gov/7780649 DM8S173 DI DM8S173 DM8S173 DN TAK-201 DM8S173 MI TTYJQTF DM8S173 MN Immunoglobulin E (IgE) DM8S173 MT DTT DM8S173 MA Modulator DM8S173 RN Adecatumumab: an anti-EpCAM monoclonal antibody, from the bench to the bedside. Expert Opin Biol Ther. 2010 Jun;10(6):951-8. DM8S173 RU https://pubmed.ncbi.nlm.nih.gov/20426706 DM7S69Q DI DM7S69Q DM7S69Q DN TAK-218 DM7S69Q MI TTV0YFR DM7S69Q MN Lipid peroxidation (LPO) DM7S69Q MT DTT DM7S69Q MA Modulator DM7S69Q RN ESR study on the antioxidant activity of TAK-218 in biological model membranes. Chem Pharm Bull (Tokyo). 2000 Jun;48(6):784-92. DM7S69Q RU https://pubmed.ncbi.nlm.nih.gov/10866137 DMG4RFO DI DMG4RFO DMG4RFO DN TAK-442 DMG4RFO MI TTCIHJA DMG4RFO MN Coagulation factor Xa (F10) DMG4RFO MT DTT DMG4RFO MA Inhibitor DMG4RFO RN Clinical pipeline report, company report or official report of Takeda (2009). DMG4RFO RU http://www.takeda.com/pdf/usr/default/10_1_34992_2.pdf DMN1YHP DI DMN1YHP DMN1YHP DN TAK-603 DMN1YHP MI TT93WF5 DMN1YHP MN Interferon-gamma (IFNG) DMN1YHP MT DTT DMN1YHP MA Modulator DMN1YHP RN T helper 1 inhibitor TAK-603 inhibits IFN-gamma and IL-12 production with no effect on IL-18: an observation in sarcoidosis patients. Sarcoidosis Vasc Diffuse Lung Dis. 2004 Oct;21(3):204-11. DMN1YHP RU https://pubmed.ncbi.nlm.nih.gov/15554077 DMDVJKW DI DMDVJKW DMDVJKW DN TAK-637 DMDVJKW MI TTZPO1L DMDVJKW MN Substance-P receptor (TACR1) DMDVJKW MT DTT DMDVJKW MA Antagonist DMDVJKW RN Novel drugs and therapeutic targets for severe mood disorders. Neuropsychopharmacology. 2008 Aug;33(9):2080-92. DMDVJKW RU https://pubmed.ncbi.nlm.nih.gov/18172433 DMHNZ31 DI DMHNZ31 DMHNZ31 DN TAK-802 DMHNZ31 MI TT1RS9F DMHNZ31 MN Acetylcholinesterase (AChE) DMHNZ31 MT DTT DMHNZ31 MA Inhibitor DMHNZ31 RN Effects of TAK-802, a novel acetylcholinesterase inhibitor, on distension-induced rhythmic bladder contractions in rats and guinea pigs. Eur J Pharmacol. 2004 Feb 6;485(1-3):299-305. DMHNZ31 RU https://pubmed.ncbi.nlm.nih.gov/14757154 DMWVPEU DI DMWVPEU DMWVPEU DN Tallimustine DMWVPEU MI TTUTN1I DMWVPEU MN Human Deoxyribonucleic acid (hDNA) DMWVPEU MT DTT DMWVPEU MA Modulator DMWVPEU RN Sequence-specific DNA alkylation of novel tallimustine derivatives. Anticancer Drug Des. 1998 Apr;13(3):193-205. DMWVPEU RU https://www.ncbi.nlm.nih.gov/pubmed/9595033 DM2KH9Y DI DM2KH9Y DM2KH9Y DN Talsaclidine fumarate DM2KH9Y MI TTZ9SOR DM2KH9Y MN Muscarinic acetylcholine receptor M1 (CHRM1) DM2KH9Y MT DTT DM2KH9Y MA Agonist DM2KH9Y RN Pharmacological comparison of muscarinic ligands: historical versus more recent muscarinic M1-preferring receptor agonists. Eur J Pharmacol. 2009 Mar 1;605(1-3):53-6. DM2KH9Y RU https://pubmed.ncbi.nlm.nih.gov/19168056 DM1L5UX DI DM1L5UX DM1L5UX DN TAMOLARIZINE HYDROCHLORIDE DM1L5UX MI TT5HONZ DM1L5UX MN Calcium channel unspecific (CaC) DM1L5UX MT DTT DM1L5UX MA Blocker DM1L5UX RN Reversal of multidrug resistance in human leukemia K562 by tamolarizine, a novel calcium antagonist. Jpn J Pharmacol. 2000 Mar;82(3):265-8. DM1L5UX RU https://pubmed.ncbi.nlm.nih.gov/10887958 DMNU2MH DI DMNU2MH DMNU2MH DN Tandutinib DMNU2MH MI TTGJCWZ DMNU2MH MN Fms-like tyrosine kinase 3 (FLT-3) DMNU2MH MT DTT DMNU2MH MA Inhibitor DMNU2MH RN A comparison of physicochemical property profiles of marketed oral drugs and orally bioavailable anti-cancer protein kinase inhibitors in clinical development. Curr Top Med Chem. 2007;7(14):1408-22. DMNU2MH RU https://pubmed.ncbi.nlm.nih.gov/17692029 DMF1VY4 DI DMF1VY4 DMF1VY4 DN Taprizosin DMF1VY4 MI TTNGILX DMF1VY4 MN Adrenergic receptor alpha-1A (ADRA1A) DMF1VY4 MT DTT DMF1VY4 MA Antagonist DMF1VY4 RN Impact of physicochemical and structural properties on the pharmacokinetics of a series of alpha1L-adrenoceptor antagonists. Drug Metab Dispos. 2007 Aug;35(8):1435-45. DMF1VY4 RU https://pubmed.ncbi.nlm.nih.gov/17502340 DMX6ZYE DI DMX6ZYE DMX6ZYE DN Tarazepide DMX6ZYE MI TTCG0AL DMX6ZYE MN Cholecystokinin receptor type A (CCKAR) DMX6ZYE MT DTT DMX6ZYE MA Antagonist DMX6ZYE RN Melatonin as modulator of pancreatic enzyme secretion and pancreatoprotector. J Physiol Pharmacol. 2007 Dec;58 Suppl 6:65-80. DMX6ZYE RU https://pubmed.ncbi.nlm.nih.gov/18212401 DMJG7VP DI DMJG7VP DMJG7VP DN Tariquidar DMJG7VP MI TT3OT40 DMJG7VP MN Multidrug resistance protein 1 (ABCB1) DMJG7VP MT DTT DMJG7VP MA Modulator DMJG7VP RN Inhibition of P-glycoprotein (ABCB1)- and multidrug resistance-associated protein 1 (ABCC1)-mediated transport by the orally administered inhibitor, CBT-1((R)).Biochem Pharmacol.2008 Mar 15;75(6):1302-12. DMJG7VP RU https://www.ncbi.nlm.nih.gov/pubmed/18234154 DMP1A4S DI DMP1A4S DMP1A4S DN TC-2696 DMP1A4S MI TTL1ATN DMP1A4S MN Neuronal acetylcholine receptor alpha-4/beta-2 (CHRNA4/B2) DMP1A4S MT DTT DMP1A4S MA Modulator DMP1A4S RN alpha4beta2 Nicotinic receptors play a role in the nAChR-mediated decline in L-dopa-induced dyskinesias in parkinsonian rats. Neuropharmacology. 2013 Aug;71:191-203. DMP1A4S RU https://pubmed.ncbi.nlm.nih.gov/23583932 DM3VZ87 DI DM3VZ87 DM3VZ87 DN TCV-309 DM3VZ87 MI TTQL5VC DM3VZ87 MN Platelet-activating factor receptor (PTAFR) DM3VZ87 MT DTT DM3VZ87 MA Modulator DM3VZ87 RN Inhibitory effect of TCV-309, a novel platelet activating factor (PAF) antagonist, on endotoxin-induced disseminated intravascular coagulation in r... Thromb Res. 1993 May 15;70(4):281-93. DM3VZ87 RU https://www.ncbi.nlm.nih.gov/pubmed/8332959 DMMUE8P DI DMMUE8P DMMUE8P DN TEBUFELONE DMMUE8P MI TT2J34L DMMUE8P MN Arachidonate 5-lipoxygenase (5-LOX) DMMUE8P MT DTT DMMUE8P MA Inhibitor DMMUE8P RN New cyclooxygenase-2/5-lipoxygenase inhibitors. 2. 7-tert-butyl-2,3-dihydro-3,3-dimethylbenzofuran derivatives as gastrointestinal safe antiinflamm... J Med Chem. 1998 Mar 26;41(7):1124-37. DMMUE8P RU https://pubmed.ncbi.nlm.nih.gov/9544212 DMMUE8P DI DMMUE8P DMMUE8P DN TEBUFELONE DMMUE8P MI TTSJ6Q4 DMMUE8P MN LOX-5 messenger RNA (ALOX5 mRNA) DMMUE8P MT DTT DMMUE8P MA Inhibitor DMMUE8P RN New cyclooxygenase-2/5-lipoxygenase inhibitors. 3. 7-tert-butyl-2, 3-dihydro-3,3-dimethylbenzofuran derivatives as gastrointestinal safe antiinflam... J Med Chem. 1998 Aug 27;41(18):3515-29. DMMUE8P RU https://pubmed.ncbi.nlm.nih.gov/9719605 DMMUE8P DI DMMUE8P DMMUE8P DN TEBUFELONE DMMUE8P MI TT8NGED DMMUE8P MN Prostaglandin G/H synthase 1 (COX-1) DMMUE8P MT DTT DMMUE8P MA Inhibitor DMMUE8P RN New cyclooxygenase-2/5-lipoxygenase inhibitors. 2. 7-tert-butyl-2,3-dihydro-3,3-dimethylbenzofuran derivatives as gastrointestinal safe antiinflamm... J Med Chem. 1998 Mar 26;41(7):1124-37. DMMUE8P RU https://pubmed.ncbi.nlm.nih.gov/9544212 DMMUE8P DI DMMUE8P DMMUE8P DN TEBUFELONE DMMUE8P MI TTVKILB DMMUE8P MN Prostaglandin G/H synthase 2 (COX-2) DMMUE8P MT DTT DMMUE8P MA Inhibitor DMMUE8P RN New cyclooxygenase-2/5-lipoxygenase inhibitors. 2. 7-tert-butyl-2,3-dihydro-3,3-dimethylbenzofuran derivatives as gastrointestinal safe antiinflamm... J Med Chem. 1998 Mar 26;41(7):1124-37. DMMUE8P RU https://pubmed.ncbi.nlm.nih.gov/9544212 DMPCRUT DI DMPCRUT DMPCRUT DN Teglicar DMPCRUT MI TTC8M31 DMPCRUT MN Carnitine acyltransferase (CRAT) DMPCRUT MT DTT DMPCRUT MA Inhibitor DMPCRUT RN Selective Reversible Inhibition of Liver Carnitine Palmitoyl-Transferase 1 by Teglicar Reduces Gluconeogenesis and Improves Glucose Homeostasis. Diabetes. 2011 February; 60(2): 644-651. DMPCRUT RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3028366/ DM3F5E0 DI DM3F5E0 DM3F5E0 DN TEI-6122 DM3F5E0 MI TT9B4N3 DM3F5E0 MN Prostaglandin receptor (PTGR) DM3F5E0 MT DTT DM3F5E0 MA Modulator DM3F5E0 RN The effect of a synthetic 7-thiaprostaglandin E1 derivative, TEI-6122, on monocyte chemoattractant protein-1 induced chemotaxis in THP-1 cells.. Br J Pharmacol. 1995 October; 116(4): 2298-2302. DM3F5E0 RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1908987/ DMIDGZU DI DMIDGZU DMIDGZU DN Telbermin DMIDGZU MI TT2Q6G1 DMIDGZU MN Vascular endothelial growth factor receptor 1 (FLT-1) DMIDGZU MT DTT DMIDGZU MA Activator DMIDGZU RN Emerging drugs for diabetic foot ulcers. Expert Opin Emerg Drugs. 2006 Nov;11(4):709-24. DMIDGZU RU https://pubmed.ncbi.nlm.nih.gov/17064227 DM8OWID DI DM8OWID DM8OWID DN Telinavir DM8OWID MI TT5FNQT DM8OWID MN Human immunodeficiency virus Protease (HIV PR) DM8OWID MT DTT DM8OWID MA Inhibitor DM8OWID RN Improvement of bioavailability of the HIV protease inhibitor SC-52151 in the beagle dog by coadministration of the CYP3A4 inhibitor, ketoconazole. Xenobiotica. 1997 May;27(5):489-97. DM8OWID RU https://pubmed.ncbi.nlm.nih.gov/9179989 DM4K3P9 DI DM4K3P9 DM4K3P9 DN Terflavoxate DM4K3P9 MI TTOXS3C DM4K3P9 MN Muscarinic acetylcholine receptor (CHRM) DM4K3P9 MT DTT DM4K3P9 MA Modulator DM4K3P9 RN Effects of terflavoxate on stimulated contractions of urinary bladder in vitro. Arzneimittelforschung. 1993 Feb;43(2):122-8. DM4K3P9 RU https://pubmed.ncbi.nlm.nih.gov/8384453 DMPB36I DI DMPB36I DMPB36I DN Tesmilifene DMPB36I MI DECB0K3 DMPB36I MN Cytochrome P450 2D6 (CYP2D6) DMPB36I MT DME DMPB36I MA Metabolism DMPB36I RN N,N-diethyl-2-[4-(phenylmethyl)phenoxy] ethanamine (DPPE) a chemopotentiating and cytoprotective agent in clinical trials: interaction with histamine at cytochrome P450 3A4 and other isozymes that metabolize antineoplastic drugs. Cancer Chemother Pharmacol. 2000;45(4):298-304. DMPB36I RU https://www.ncbi.nlm.nih.gov/pubmed/?term=10755318 DMPB36I DI DMPB36I DMPB36I DN Tesmilifene DMPB36I MI DE4LYSA DMPB36I MN Cytochrome P450 3A4 (CYP3A4) DMPB36I MT DME DMPB36I MA Metabolism DMPB36I RN Effects of tesmilifene, a substrate of CYP3A and an inhibitor of P-glycoprotein, on the pharmacokinetics of intravenous and oral docetaxel in rats. J Pharm Pharmacol. 2010 Aug;62(8):1084-8. DMPB36I RU https://www.ncbi.nlm.nih.gov/pubmed/?term=20663044 DMPB36I DI DMPB36I DMPB36I DN Tesmilifene DMPB36I MI TT7CXIM DMPB36I MN Histamine receptor (HR) DMPB36I MT DTT DMPB36I MA Modulator DMPB36I RN Effects of tesmilifene, a substrate of CYP3A and an inhibitor of P-glycoprotein, on the pharmacokinetics of intravenous and oral docetaxel in rats. J Pharm Pharmacol. 2010 Aug;62(8):1084-8. DMPB36I RU https://pubmed.ncbi.nlm.nih.gov/20663044 DM5O6HM DI DM5O6HM DM5O6HM DN Testosterone glucoside DM5O6HM MI TTS64P2 DM5O6HM MN Androgen receptor (AR) DM5O6HM MT DTT DM5O6HM MA Agonist DM5O6HM RN Evidence for a role of testosterone-androgen receptor interactions in mediating masculine sexual behavior in male rats. Endocrinology. 1989 Feb;124(2):618-26. DM5O6HM RU https://pubmed.ncbi.nlm.nih.gov/2912689 DMC0WNB DI DMC0WNB DMC0WNB DN Tetramethylpyrazine DMC0WNB MI TTJR60Z DMC0WNB MN Endothelin-1 (EDN1) DMC0WNB MT DTT DMC0WNB MA Modulator DMC0WNB RN Tetramethylpyrazine, a Chinese drug, blocks coronary vasoconstriction by endothelin-1 and decreases plasma endothelin-1 levels in experimental animals. J Cardiovasc Pharmacol. 1998;31 Suppl 1:S313-6. DMC0WNB RU https://pubmed.ncbi.nlm.nih.gov/9595468 DMS4BUK DI DMS4BUK DMS4BUK DN TG-1042 DMS4BUK MI TT93WF5 DMS4BUK MN Interferon-gamma (IFNG) DMS4BUK MT DTT DMS4BUK MA Modulator DMS4BUK RN Drug evaluation: TG-1042, an adenovirus-mediated IFNgamma gene delivery for the intratumoral therapy of primary cutaneous lymphomas. Curr Opin Investig Drugs. 2007 Jun;8(6):493-8. DMS4BUK RU https://pubmed.ncbi.nlm.nih.gov/17621880 DMQSNV8 DI DMQSNV8 DMQSNV8 DN TgAAV-CFTR DMQSNV8 MI TTCYAXN DMQSNV8 MN Chloride channel unspecific (ClC) DMQSNV8 MT DTT DMQSNV8 MA Modulator DMQSNV8 RN Novel molecular approaches to cystic fibrosis gene therapy. Biochem J. 2005 April 1; 387(Pt 1): 1-15. DMQSNV8 RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1134927/ DMYN6G0 DI DMYN6G0 DMYN6G0 DN TGP-580 DMYN6G0 MI TTGKIED DMYN6G0 MN Fibroblast growth factor-2 (FGF2) DMYN6G0 MT DTT DMYN6G0 MA Modulator DMYN6G0 RN Expression of fibroblast growth factor-2 transcripts in the healing of acetic acid-induced gastric ulcers. APMIS. 1999 Aug;107(8):767-72. DMYN6G0 RU https://pubmed.ncbi.nlm.nih.gov/10515127 DMGR7Y3 DI DMGR7Y3 DMGR7Y3 DN Theradigm-HBV DMGR7Y3 MI TTZTEFH DMGR7Y3 MN Major histocompatibility complex (MHC) DMGR7Y3 MT DTT DMGR7Y3 MA Modulator DMGR7Y3 RN Molecular features of the hepatitis B virus nucleocapsid T-cell epitope 18-27: interaction with HLA and T-cell receptor. Hepatology. 1997 Oct;26(4):1027-34. DMGR7Y3 RU https://pubmed.ncbi.nlm.nih.gov/9328331 DMYH2PU DI DMYH2PU DMYH2PU DN TIBENELAST DMYH2PU MI TTUST1O DMYH2PU MN Phosphodiesterase (PDE) DMYH2PU MT DTT DMYH2PU MA Inhibitor DMYH2PU RN Effect of tibenelast (a phosphodiesterase inhibitor) and theophylline on isoproterenol-stimulated heart rate, cyclic AMP and norepinephrine levels. Pharmacology. 1993;46(3):142-7. DMYH2PU RU https://pubmed.ncbi.nlm.nih.gov/8382824 DMLWBYO DI DMLWBYO DMLWBYO DN Tienoxolol DMLWBYO MI TTMXGCW DMLWBYO MN Adrenergic receptor beta-3 (ADRB3) DMLWBYO MT DTT DMLWBYO MA Modulator DMLWBYO RN Effects of the beta-adrenoceptor antagonists atenolol and propranolol on human parotid and submandibular-sublingual salivary secretion. J Dent Res. 1994 Jan;73(1):5-10. DMLWBYO RU https://pubmed.ncbi.nlm.nih.gov/8294618 DMPWSRA DI DMPWSRA DMPWSRA DN Tilmacoxib DMPWSRA MI TTVKILB DMPWSRA MN Prostaglandin G/H synthase 2 (COX-2) DMPWSRA MT DTT DMPWSRA MA Inhibitor DMPWSRA RN 4-(4-cycloalkyl/aryl-oxazol-5-yl)benzenesulfonamides as selective cyclooxygenase-2 inhibitors: enhancement of the selectivity by introduction of a ... J Med Chem. 2002 Mar 28;45(7):1511-7. DMPWSRA RU https://pubmed.ncbi.nlm.nih.gov/11906292 DMUJ2X6 DI DMUJ2X6 DMUJ2X6 DN Tiqueside DMUJ2X6 MI TTNA5ZS DMUJ2X6 MN Cholesterol absorption (Chole absorp) DMUJ2X6 MT DTT DMUJ2X6 MA Modulator DMUJ2X6 RN Inhibiting cholesterol absorption with CP-88,818 (beta-tigogenin cellobioside; tiqueside): studies in normal and hyperlipidemic subjects. J Cardiovasc Pharmacol. 1997 Jul;30(1):55-60. DMUJ2X6 RU https://pubmed.ncbi.nlm.nih.gov/9268221 DMGF35T DI DMGF35T DMGF35T DN Tisocalcitate DMGF35T MI TTK59TV DMGF35T MN Vitamin D3 receptor (VDR) DMGF35T MT DTT DMGF35T MA Inhibitor DMGF35T RN The Rationale Behind Topical Vitamin D Analogs in the Treatment of Psoriasis: Where Does Topical Calcitriol Fit In . J Clin Aesthet Dermatol. 2010 August; 3(8): 46-53. DMGF35T RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2945865/ DMXNQLU DI DMXNQLU DMXNQLU DN TM30338 DMXNQLU MI TTJ6WK9 DMXNQLU MN Neuropeptide Y receptor type 2 (NPY2R) DMXNQLU MT DTT DMXNQLU MA Modulator DMXNQLU RN Anti-Obesity Drug Discovery and Development, Atta-ur- Rahman, page(108) DMXNQLU RU https://books.google.com.hk/books?id=lc4WdvCmD54C&pg=PA108&lpg=PA108&dq=obinepitide++agonist%27&source=bl&ots=8jUZzCOibY&sig=RbRzNpJyEKp_V0-bNYHEwcTnPL8&hl=zh-CN&sa=X#v=onepage&q=obinepitide%20%20agonist%27&f=false DMXNQLU DI DMXNQLU DMXNQLU DN TM30338 DMXNQLU MI TTW4N16 DMXNQLU MN Neuropeptide Y receptor type 4 (NPY4R) DMXNQLU MT DTT DMXNQLU MA Modulator DMXNQLU RN Anti-Obesity Drug Discovery and Development, Atta-ur- Rahman, page(108) DMXNQLU RU https://books.google.com.hk/books?id=lc4WdvCmD54C&pg=PA108&lpg=PA108&dq=obinepitide++agonist%27&source=bl&ots=8jUZzCOibY&sig=RbRzNpJyEKp_V0-bNYHEwcTnPL8&hl=zh-CN&sa=X#v=onepage&q=obinepitide%20%20agonist%27&f=false DMW7LQT DI DMW7LQT DMW7LQT DN TM30339 DMW7LQT MI TTW4N16 DMW7LQT MN Neuropeptide Y receptor type 4 (NPY4R) DMW7LQT MT DTT DMW7LQT MA Agonist DMW7LQT RN Neuropeptide y receptor selective ligands in the treatment of obesity. Endocr Rev. 2007 Oct;28(6):664-84. DMW7LQT RU https://pubmed.ncbi.nlm.nih.gov/17785427 DMW05DS DI DMW05DS DMW05DS DN TNP-351 DMW05DS MI TTYZVDJ DMW05DS MN Dihydrofolate reductase (DHFR) DMW05DS MT DTT DMW05DS MA Inhibitor DMW05DS RN A Ring-Transformation/Ring-Annulation Strategy for the Synthesis of the DHFR Inhibitor, TNP-351: A Correction. J Org Chem. 1996 Nov 1;61(22):7973-7974. DMW05DS RU https://pubmed.ncbi.nlm.nih.gov/11667765 DMT0QK8 DI DMT0QK8 DMT0QK8 DN TNP-470 DMT0QK8 MI TTZL0OI DMT0QK8 MN Methionine aminopeptidase 2 (METAP2) DMT0QK8 MT DTT DMT0QK8 MA Inhibitor DMT0QK8 RN Tumor suppression by a rationally designed reversible inhibitor of methionine aminopeptidase-2. Cancer Res. 2003 Nov 15;63(22):7861-9. DMT0QK8 RU https://pubmed.ncbi.nlm.nih.gov/14633714 DMEROU4 DI DMEROU4 DMEROU4 DN Tolafentrine DMEROU4 MI DTUGYRD DMEROU4 MN P-glycoprotein 1 (ABCB1) DMEROU4 MT DTP DMEROU4 MA Substrate DMEROU4 RN A novel screening strategy to identify ABCB1 substrates and inhibitors. Naunyn Schmiedebergs Arch Pharmacol. 2009 Jan;379(1):11-26. DMEROU4 RU https://doi.org/10.1007/s00210-008-0345-0 DMEROU4 DI DMEROU4 DMEROU4 DN Tolafentrine DMEROU4 MI TTZCG4L DMEROU4 MN Phosphodiesterase 3 (PDE3) DMEROU4 MT DTT DMEROU4 MA Modulator DMEROU4 RN Inhaled tolafentrine reverses pulmonary vascular remodeling via inhibition of smooth muscle cell migration DMEROU4 RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1291406 DMY40KZ DI DMY40KZ DMY40KZ DN Tomeglovir DMY40KZ MI TTIU7X1 DMY40KZ MN Herpes simplex virus DNA polymerase UL30 (HSV UL30) DMY40KZ MT DTT DMY40KZ MA Inhibitor DMY40KZ RN Focus on new drugs in development against human cytomegalovirus. Drugs. 2002;62(13):1853-8. DMY40KZ RU https://pubmed.ncbi.nlm.nih.gov/12215056 DM1YXPL DI DM1YXPL DM1YXPL DN Tomopenem DM1YXPL MI TTJP4SM DM1YXPL MN Bacterial Penicillin binding protein (Bact PBP) DM1YXPL MT DTT DM1YXPL MA Modulator DM1YXPL RN Affinity of Tomopenem (CS-023) for penicillin-binding proteins in Staphylococcus aureus, Escherichia coli, and Pseudomonas aeruginosa.Antimicrob Agents Chemother.2009 Mar;53(3):1238-41. DM1YXPL RU https://www.ncbi.nlm.nih.gov/pubmed/19104025 DMZA06U DI DMZA06U DMZA06U DN TOPIXANTRONE HYDROCHLORIDE DMZA06U MI TTUTN1I DMZA06U MN Human Deoxyribonucleic acid (hDNA) DMZA06U MT DTT DMZA06U MA Inhibitor DMZA06U RN Clinical pipeline report, company report or official report of CTI BioPharma. DMZA06U RU http://www.ctibiopharma.com/pipeline/pixantrone/ DMDHYM7 DI DMDHYM7 DMDHYM7 DN Torcetrapib DMDHYM7 MI TTFQAYR DMDHYM7 MN Cholesteryl ester transfer protein (CETP) DMDHYM7 MT DTT DMDHYM7 MA Inhibitor DMDHYM7 RN Safety and tolerability of dalcetrapib. Am J Cardiol. 2009 Jul 1;104(1):82-91. DMDHYM7 RU https://pubmed.ncbi.nlm.nih.gov/19576325 DMDHYM7 DI DMDHYM7 DMDHYM7 DN Torcetrapib DMDHYM7 MI DE4LYSA DMDHYM7 MN Cytochrome P450 3A4 (CYP3A4) DMDHYM7 MT DME DMDHYM7 MA Metabolism DMDHYM7 RN Pharmacokinetics, metabolism, and excretion of torcetrapib, a cholesteryl ester transfer protein inhibitor, in humans. Drug Metab Dispos. 2008 Nov;36(11):2185-98. DMDHYM7 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=18694908 DMX32RC DI DMX32RC DMX32RC DN Transdur-sufentanil DMX32RC MI TTKWM86 DMX32RC MN Opioid receptor mu (MOP) DMX32RC MT DTT DMX32RC MA Agonist DMX32RC RN [3H]Sufentanil, a superior ligand for mu-opiate receptors: binding properties and regional distribution in rat brain and spinal cord. Eur J Pharmacol. 1983 Feb 18;87(2-3):209-25. DMX32RC RU https://pubmed.ncbi.nlm.nih.gov/6132825 DME85Z9 DI DME85Z9 DME85Z9 DN TREFENTANIL HYDROCHLORIDE DME85Z9 MI TTKWM86 DME85Z9 MN Opioid receptor mu (MOP) DME85Z9 MT DTT DME85Z9 MA Agonist DME85Z9 RN Pharmacokinetic-pharmacodynamic modeling in drug development: application to the investigational opioid trefentanil. Clin Pharmacol Ther. 1994 Sep;56(3):261-71. DME85Z9 RU https://pubmed.ncbi.nlm.nih.gov/7924121 DMUZNF0 DI DMUZNF0 DMUZNF0 DN Tridolgosir DMUZNF0 MI TT34DCN DMUZNF0 MN Golgi alpha-mannosidase II (MAN2A1) DMUZNF0 MT DTT DMUZNF0 MA Inhibitor DMUZNF0 RN Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800010383) DMUZNF0 RU http://adisinsight.springer.com/drugs/800010383 DMZ98Y4 DI DMZ98Y4 DMZ98Y4 DN TRO-40303 DMZ98Y4 MI TTPTXIN DMZ98Y4 MN Translocator protein (TSPO) DMZ98Y4 MT DTT DMZ98Y4 MA Modulator DMZ98Y4 RN Translation of TRO40303 from myocardial infarction models to demonstration of safety and tolerance in a randomized Phase I trial. J Transl Med. 2014; 12: 38. DMZ98Y4 RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3923730/ DM6032E DI DM6032E DM6032E DN Trombodipine DM6032E MI TT438XZ DM6032E MN Cyclin D1/E2F pathway (CCND1/E2F pathway) DM6032E MT DTT DM6032E MA Modulator DM6032E RN Inhibition of the cyclin D1/E2F pathway by PCA-4230, a potent repressor of cellular proliferation. Br J Pharmacol. 2001 April; 132(7): 1597-1605. DM6032E RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1572687/ DMALIFO DI DMALIFO DMALIFO DN TS-033 DMALIFO MI TTLWPVF DMALIFO MN Sodium/glucose cotransporter 2 (SGLT2) DMALIFO MT DTT DMALIFO MA Modulator DMALIFO RN Company report (Taisho) DMALIFO RU http://www.taisho.co.jp/en/company/release/2008/2008100201-e.pdf DMWXOJN DI DMWXOJN DMWXOJN DN TT-62 DMWXOJN MI TTU6BFZ DMWXOJN MN Candida Thymidylate synthase (Candi TMP1) DMWXOJN MT DTT DMWXOJN MA Inhibitor DMWXOJN RN TECHNOLOGY, PRODUCTS, MARKETS AND SERVICE OPPORTUNITIES. Future Oncology. AUGUST 1995. VOLUME 1, NUMBER 4. DMWXOJN RU http://www.oncologyknowledgebase.net/futureoncology/pdfs/Future_Oncology.Vol.1.No.4.pdf DMCEGN4 DI DMCEGN4 DMCEGN4 DN TTP-355 DMCEGN4 MI TTDLNGZ DMCEGN4 MN Glucokinase (GCK) DMCEGN4 MT DTT DMCEGN4 MA Activator DMCEGN4 RN Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800025266) DMCEGN4 RU http://adisinsight.springer.com/drugs/800025266 DM81XLA DI DM81XLA DM81XLA DN TV-4710 DM81XLA MI TTUTN1I DM81XLA MN Human Deoxyribonucleic acid (hDNA) DM81XLA MT DTT DM81XLA MA Inhibitor DM81XLA RN Emergence of targeted immune therapies for systemic lupus. Expert Opin Emerg Drugs. 2005 Feb;10(1):53-65. DM81XLA RU https://pubmed.ncbi.nlm.nih.gov/15757403 DMQWA2R DI DMQWA2R DMQWA2R DN TY-11345 DMQWA2R MI TTLOKXP DMQWA2R MN Gastric H(+)/K(+) ATPase (Proton pump) DMQWA2R MT DTT DMQWA2R MA Modulator DMQWA2R RN Biochemical and pharmacological properties of a newly synthesized proton pump (H+/K(+)-ATPase) inhibitor, TY-11345 in experimental animals. Jpn J Pharmacol. 1993 Aug;62(4):363-71. DMQWA2R RU https://pubmed.ncbi.nlm.nih.gov/8230863 DM4FZWP DI DM4FZWP DM4FZWP DN UK-279,276 DM4FZWP MI TTIJWR7 DM4FZWP MN Integrin beta-2 (ITGB2) DM4FZWP MT DTT DM4FZWP MA Antagonist DM4FZWP RN Advances in ischemic stroke treatment: neuroprotective and combination therapies. Expert Opin Emerg Drugs. 2007 Mar;12(1):97-112. DM4FZWP RU https://pubmed.ncbi.nlm.nih.gov/17355216 DMAD1S5 DI DMAD1S5 DMAD1S5 DN UK-74505 DMAD1S5 MI TTQL5VC DMAD1S5 MN Platelet-activating factor receptor (PTAFR) DMAD1S5 MT DTT DMAD1S5 MA Antagonist DMAD1S5 RN Differential effects of the PAF receptor antagonist UK-74,505 on neutrophil and eosinophil accumulation in guinea-pig skin. Br J Pharmacol. 1994 Oct;113(2):513-21. DMAD1S5 RU https://pubmed.ncbi.nlm.nih.gov/7834203 DMRDXYV DI DMRDXYV DMRDXYV DN Ultramorph DMRDXYV MI TTN4QDT DMRDXYV MN Opioid receptor (OPR) DMRDXYV MT DTT DMRDXYV MA Agonist DMRDXYV RN Antagonists of excitatory opioid receptor functions enhance morphine's analgesic potency and attenuate opioid tolerance/dependence liability. Pain. 2000 Feb;84(2-3):121-31. DMRDXYV RU https://pubmed.ncbi.nlm.nih.gov/10666516 DMBJ8KG DI DMBJ8KG DMBJ8KG DN Urtoxazumab DMBJ8KG MI TTRV7FQ DMBJ8KG MN Enterobacteria Shiga-like toxin 2B (EntBac stxB2) DMBJ8KG MT DTT DMBJ8KG RN Safety and pharmacokinetics of urtoxazumab, a humanized monoclonal antibody, against Shiga-like toxin 2 in healthy adults and in pediatric patients infected with Shiga-like toxin-producing Escherichia coli. Antimicrob Agents Chemother. 2010 Jan;54(1):239-43. DMBJ8KG RU https://pubmed.ncbi.nlm.nih.gov/19822704 DMOB2K5 DI DMOB2K5 DMOB2K5 DN UTIBAPRIL DMOB2K5 MI TTL69WB DMOB2K5 MN Angiotensin-converting enzyme (ACE) DMOB2K5 MT DTT DMOB2K5 MA Inhibitor DMOB2K5 RN Differential inhibition of plasma versus tissue ACE by utibapril: biochemical and functional evidence for inhibition of vascular ACE activity. J Cardiovasc Pharmacol. 1997 May;29(5):684-91. DMOB2K5 RU https://pubmed.ncbi.nlm.nih.gov/9213213 DMEV1H5 DI DMEV1H5 DMEV1H5 DN V-11294A DMEV1H5 MI TTZ97H5 DMEV1H5 MN Phosphodiesterase 4A (PDE4A) DMEV1H5 MT DTT DMEV1H5 MA Inhibitor DMEV1H5 RN Pharmacokinetic and pharmacodynamic profile following oral administration of the phosphodiesterase (PDE)4 inhibitor V11294A in healthy volunteers. Br J Clin Pharmacol. 2002 Nov;54(5):478-84. DMEV1H5 RU https://pubmed.ncbi.nlm.nih.gov/12445026 DMEV1H5 DI DMEV1H5 DMEV1H5 DN V-11294A DMEV1H5 MI TTVIAT9 DMEV1H5 MN Phosphodiesterase 4B (PDE4B) DMEV1H5 MT DTT DMEV1H5 MA Inhibitor DMEV1H5 RN Pharmacokinetic and pharmacodynamic profile following oral administration of the phosphodiesterase (PDE)4 inhibitor V11294A in healthy volunteers. Br J Clin Pharmacol. 2002 Nov;54(5):478-84. DMEV1H5 RU https://pubmed.ncbi.nlm.nih.gov/12445026 DMEV1H5 DI DMEV1H5 DMEV1H5 DN V-11294A DMEV1H5 MI TTSKMI8 DMEV1H5 MN Phosphodiesterase 4D (PDE4D) DMEV1H5 MT DTT DMEV1H5 MA Inhibitor DMEV1H5 RN Pharmacokinetic and pharmacodynamic profile following oral administration of the phosphodiesterase (PDE)4 inhibitor V11294A in healthy volunteers. Br J Clin Pharmacol. 2002 Nov;54(5):478-84. DMEV1H5 RU https://pubmed.ncbi.nlm.nih.gov/12445026 DMXQCBU DI DMXQCBU DMXQCBU DN Valtorcitabine DMXQCBU MI TTT4SY6 DMXQCBU MN Hepatitis B virus Polymerase (HBV P) DMXQCBU MT DTT DMXQCBU MA Inhibitor DMXQCBU RN Prodrugs of nucleoside analogues for improved oral absorption and tissue targeting. J Pharm Sci. 2008 Mar;97(3):1109-34. DMXQCBU RU https://pubmed.ncbi.nlm.nih.gov/17696166 DMHCOFM DI DMHCOFM DMHCOFM DN Vasoflux DMHCOFM MI TT6L509 DMHCOFM MN Coagulation factor IIa (F2) DMHCOFM MT DTT DMHCOFM MA Inhibitor DMHCOFM RN Vasoflux, a new anticoagulant with a novel mechanism of action. Circulation. 1999 Feb 9;99(5):682-9. DMHCOFM RU https://pubmed.ncbi.nlm.nih.gov/9950667 DMROSHN DI DMROSHN DMROSHN DN Velneperit DMROSHN MI TTY6EWA DMROSHN MN Neuropeptide Y receptor type 5 (NPY5R) DMROSHN MT DTT DMROSHN MA Antagonist DMROSHN RN Clinical pipeline report, company report or official report of Shionogi (2011). DMROSHN RU http://www.shionogi.co.jp/index_e.html DMHCLVQ DI DMHCLVQ DMHCLVQ DN Vitaxin DMHCLVQ MI TT69TQN DMHCLVQ MN Integrin alpha-V/beta-3 (ITGAV/B3) DMHCLVQ MT DTT DMHCLVQ MA Modulator DMHCLVQ RN Monoclonal antibodies to alphaVbeta3 (7E3 and LM609) inhibit sickle red blood cell-endothelium interactions induced by platelet-activating factor. Blood. 2000 Jan 15;95(2):368-74. DMHCLVQ RU https://www.ncbi.nlm.nih.gov/pubmed/10627437 DMOS6CM DI DMOS6CM DMOS6CM DN VLTS-587 DMOS6CM MI TTF89GD DMOS6CM MN Interleukin-2 (IL2) DMOS6CM MT DTT DMOS6CM MA Modulator DMOS6CM RN CN patent application no. 101039956, Cell surface glycoprotein. DMOS6CM RU http://www.google.com/patents/CN101039956A?cl=en DM32N5G DI DM32N5G DM32N5G DN VOROZOLE DM32N5G MI TTSZLWK DM32N5G MN Aromatase (CYP19A1) DM32N5G MT DTT DM32N5G MA Inhibitor DM32N5G RN Chiral aromatase and dual aromatase-steroid sulfatase inhibitors from the letrozole template: synthesis, absolute configuration, and in vitro activ... J Med Chem. 2008 Jul 24;51(14):4226-38. DM32N5G RU https://pubmed.ncbi.nlm.nih.gov/18590272 DMFYM61 DI DMFYM61 DMFYM61 DN VTP-201227 DMFYM61 MI TTOQ9GZ DMFYM61 MN Cytochrome P450 reductase (P450) DMFYM61 MT DTT DMFYM61 MA Inhibitor DMFYM61 RN VTP-201227. VietMedix. DMFYM61 RU http://vietmedix.com/Drug/drug-vtp-201227.5277.html DMLCTBP DI DMLCTBP DMLCTBP DN VTX-2337 DMLCTBP MI TT8CWFK DMLCTBP MN Toll-like receptor 8 (TLR8) DMLCTBP MT DTT DMLCTBP MA Modulator DMLCTBP RN Clinical pipeline report, company report or official report of Array BioPharma (Drug: Motolimod / VTX2337). DMLCTBP RU http://www.arraybiopharma.com/product-pipeline/other-compounds/vtx-2337/ DMH4U87 DI DMH4U87 DMH4U87 DN VX-366 DMH4U87 MI TTQO71U DMH4U87 MN Hemoglobin (HB) DMH4U87 MT DTT DMH4U87 MA Inhibitor DMH4U87 RN A combination of hydroxyurea and isobutyramide to induce fetal hemoglobin in transgenic mice is more hematotoxic than the individual agents. Blood Cells Mol Dis. 1999 Jun-Aug;25(3-4):255-69. DMH4U87 RU https://pubmed.ncbi.nlm.nih.gov/10575551 DMPE5XM DI DMPE5XM DMPE5XM DN WAY-123641 DMPE5XM MI TT9V5JH DMPE5XM MN Phospholipase A2 (PLA2G1B) DMPE5XM MT DTT DMPE5XM MA Inhibitor DMPE5XM RN Phosphodiesterase-IV inhibition, respiratory muscle relaxation and bronchodilation by WAY-PDA-641. J Pharmacol Exp Ther. 1994 Feb;268(2):888-96. DMPE5XM RU https://pubmed.ncbi.nlm.nih.gov/8114002 DMLA4DU DI DMLA4DU DMLA4DU DN WC-3027 DMLA4DU MI TTYRL6O DMLA4DU MN Glucocorticoid receptor (NR3C1) DMLA4DU MT DTT DMLA4DU MA Agonist DMLA4DU RN Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800021444) DMLA4DU RU http://adisinsight.springer.com/drugs/800021444 DM7VCDZ DI DM7VCDZ DM7VCDZ DN WY-47766 DM7VCDZ MI TTTK3BH DM7VCDZ MN Vacuolar-type proton ATPase (v-ATPase) DM7VCDZ MT DTT DM7VCDZ MA Modulator DM7VCDZ RN A pharmacological assessment of the mammalian osteoclast vacuolar H(+)-ATPase. Bone Miner. 1994 Nov;27(2):159-66. DM7VCDZ RU https://pubmed.ncbi.nlm.nih.gov/7711523 DMICR39 DI DMICR39 DMICR39 DN XL784 DMICR39 MI TTMX39J DMICR39 MN Matrix metalloproteinase-1 (MMP-1) DMICR39 MT DTT DMICR39 MA Inhibitor DMICR39 RN Agents in development for the treatment of diabetic nephropathy. Expert Opin Emerg Drugs. 2008 Sep;13(3):447-63. DMICR39 RU https://pubmed.ncbi.nlm.nih.gov/18764722 DMO90RN DI DMO90RN DMO90RN DN Y-27152 DMO90RN MI TT1VOHK DMO90RN MN Potassium channel unspecific (KC) DMO90RN MT DTT DMO90RN MA Opener DMO90RN RN Pharmacokinetics and safety of a novel, long-acting, prodrug-type potassium channel opener, Y-27152, in healthy volunteers. J Clin Pharmacol. 1996 May;36(5):439-51. DMO90RN RU https://pubmed.ncbi.nlm.nih.gov/8739023 DMHFTD0 DI DMHFTD0 DMHFTD0 DN Y-700 DMHFTD0 MI TT7RJY8 DMHFTD0 MN Xanthine dehydrogenase/oxidase (XDH) DMHFTD0 MT DTT DMHFTD0 MA Inhibitor DMHFTD0 RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DMHFTD0 RU https://pubmed.ncbi.nlm.nih.gov/10592235 DML2IXO DI DML2IXO DML2IXO DN YM-114 DML2IXO MI TTPC4TU DML2IXO MN 5-HT 3A receptor (HTR3A) DML2IXO MT DTT DML2IXO MA Antagonist DML2IXO RN Effect of serotonin (5-HT)3-receptor antagonists YM060, YM114 (KAE-393), ondansetron and granisetron on 5-HT4 receptors and gastric emptying in rodents. Jpn J Pharmacol. 1995 Nov;69(3):205-14. DML2IXO RU https://pubmed.ncbi.nlm.nih.gov/8699628 DMIRSLV DI DMIRSLV DMIRSLV DN YM-17K DMIRSLV MI TTR8XOH DMIRSLV MN GPCR secretin protein unspecific (GPCRB) DMIRSLV MT DTT DMIRSLV MA Modulator DMIRSLV RN Antibiotics, Macrolides. Published Online: 18 OCT 2001. DMIRSLV RU http://onlinelibrary.wiley.com/doi/10.1002/0471238961.1301031811091819.a01.pub2/abstract DMCZIGQ DI DMCZIGQ DMCZIGQ DN YM-337 DMCZIGQ MI TT38RM1 DMCZIGQ MN Glycoprotein IIb/IIIa receptor (GPIIb/IIIa) DMCZIGQ MT DTT DMCZIGQ MA Modulator DMCZIGQ RN Pharmacodynamic characterization of the interaction between the glycoprotein IIb/IIIa inhibitor YM337 and unfractionated heparin and aspirin in hum... Br J Clin Pharmacol. 2003 Sep;56(3):321-6. DMCZIGQ RU https://www.ncbi.nlm.nih.gov/pubmed/12919181 DM7OHR6 DI DM7OHR6 DM7OHR6 DN YM-440 DM7OHR6 MI TTZMAO3 DM7OHR6 MN Peroxisome proliferator-activated receptor gamma (PPAR-gamma) DM7OHR6 MT DTT DM7OHR6 MA Inhibitor DM7OHR6 RN The novel hypoglycemic agent YM440 improves hepatic insulin resistance in obese Zucker fatty rats. J Pharmacol Sci. 2006 Aug;101(4):311-7. DM7OHR6 RU https://pubmed.ncbi.nlm.nih.gov/16891767 DM7WDAG DI DM7WDAG DM7WDAG DN YM-511 DM7WDAG MI TTSZLWK DM7WDAG MN Aromatase (CYP19A1) DM7WDAG MT DTT DM7WDAG MA Inhibitor DM7WDAG RN First dual aromatase-steroid sulfatase inhibitors. J Med Chem. 2003 Jul 17;46(15):3193-6. DM7WDAG RU https://pubmed.ncbi.nlm.nih.gov/12852749 DMDXP3C DI DMDXP3C DMDXP3C DN YM-796 DMDXP3C MI TTZ9SOR DMDXP3C MN Muscarinic acetylcholine receptor M1 (CHRM1) DMDXP3C MT DTT DMDXP3C MA Modulator DMDXP3C RN YM796, a novel muscarinic agonist, improves the impairment of learning behavior in a rat model of chronic focal cerebral ischemia. Brain Res. 1995 Jan 9;669(1):107-14. DMDXP3C RU https://www.ncbi.nlm.nih.gov/pubmed/7712153 DMWRT4L DI DMWRT4L DMWRT4L DN YM-90K DMWRT4L MI TTAN6JD DMWRT4L MN Glutamate receptor AMPA (GRIA) DMWRT4L MT DTT DMWRT4L MA Inhibitor DMWRT4L RN Synthesis and AMPA receptor antagonistic activity of a novel 7-imidazolyl-6-trifluoromethyl quinoxalinecarboxylic acid with a substituted phenyl gr... Bioorg Med Chem Lett. 2004 Oct 18;14(20):5107-11. DMWRT4L RU https://pubmed.ncbi.nlm.nih.gov/15380209 DMWRT4L DI DMWRT4L DMWRT4L DN YM-90K DMWRT4L MI TTVPQTF DMWRT4L MN Glutamate receptor AMPA 1 (GRIA1) DMWRT4L MT DTT DMWRT4L MA Inhibitor DMWRT4L RN Synthesis and AMPA receptor antagonistic activity of a novel 7-imidazolyl-6-trifluoromethyl quinoxalinecarboxylic acid with a substituted phenyl gr... Bioorg Med Chem Lett. 2004 Oct 18;14(20):5107-11. DMWRT4L RU https://pubmed.ncbi.nlm.nih.gov/15380209 DMWRT4L DI DMWRT4L DMWRT4L DN YM-90K DMWRT4L MI TT0MYE2 DMWRT4L MN Glutamate receptor ionotropic kainate 1 (GRIK1) DMWRT4L MT DTT DMWRT4L MA Inhibitor DMWRT4L RN 4,10-Dihydro-4-oxo-4H-imidazo[1,2-a]indeno[1,2-e]pyrazin-2-carboxylic acid derivatives: highly potent and selective AMPA receptors antagonists with... Bioorg Med Chem Lett. 2000 May 15;10(10):1133-7. DMWRT4L RU https://pubmed.ncbi.nlm.nih.gov/10843235 DMWRT4L DI DMWRT4L DMWRT4L DN YM-90K DMWRT4L MI TTLD29N DMWRT4L MN Glutamate receptor ionotropic NMDA 1 (NMDAR1) DMWRT4L MT DTT DMWRT4L MA Inhibitor DMWRT4L RN 4,10-Dihydro-4-oxo-4H-imidazo[1,2-a]indeno[1,2-e]pyrazin-2-carboxylic acid derivatives: highly potent and selective AMPA receptors antagonists with... Bioorg Med Chem Lett. 2000 May 15;10(10):1133-7. DMWRT4L RU https://pubmed.ncbi.nlm.nih.gov/10843235 DMWRT4L DI DMWRT4L DMWRT4L DN YM-90K DMWRT4L MI TTKJEMQ DMWRT4L MN Glutamate receptor ionotropic NMDA 2A (NMDAR2A) DMWRT4L MT DTT DMWRT4L MA Inhibitor DMWRT4L RN 4,10-Dihydro-4-oxo-4H-imidazo[1,2-a]indeno[1,2-e]pyrazin-2-carboxylic acid derivatives: highly potent and selective AMPA receptors antagonists with... Bioorg Med Chem Lett. 2000 May 15;10(10):1133-7. DMWRT4L RU https://pubmed.ncbi.nlm.nih.gov/10843235 DMWRT4L DI DMWRT4L DMWRT4L DN YM-90K DMWRT4L MI TTN9D8E DMWRT4L MN Glutamate receptor ionotropic NMDA 2B (NMDAR2B) DMWRT4L MT DTT DMWRT4L MA Inhibitor DMWRT4L RN 4,10-Dihydro-4-oxo-4H-imidazo[1,2-a]indeno[1,2-e]pyrazin-2-carboxylic acid derivatives: highly potent and selective AMPA receptors antagonists with... Bioorg Med Chem Lett. 2000 May 15;10(10):1133-7. DMWRT4L RU https://pubmed.ncbi.nlm.nih.gov/10843235 DM845NM DI DM845NM DM845NM DN YM-992 DM845NM MI TTJQOD7 DM845NM MN 5-HT 2A receptor (HTR2A) DM845NM MT DTT DM845NM MA Inhibitor DM845NM RN Serotonin reuptake inhibitors: the corner stone in treatment of depression for half a century--a medicinal chemistry survey. Curr Top Med Chem. 2006;6(17):1801-23. DM845NM RU https://pubmed.ncbi.nlm.nih.gov/17017959 DM845NM DI DM845NM DM845NM DN YM-992 DM845NM MI TT3ROYC DM845NM MN Serotonin transporter (SERT) DM845NM MT DTT DM845NM MA Inhibitor DM845NM RN Serotonin reuptake inhibitors: the corner stone in treatment of depression for half a century--a medicinal chemistry survey. Curr Top Med Chem. 2006;6(17):1801-23. DM845NM RU https://pubmed.ncbi.nlm.nih.gov/17017959 DM2438J DI DM2438J DM2438J DN Z-335 DM2438J MI TT2O84V DM2438J MN Thromboxane A2 receptor (TBXA2R) DM2438J MT DTT DM2438J MA Antagonist DM2438J RN Pharmacokinetic and pharmacodynamic properties of a new thromboxane receptor antagonist (Z-335) after single and multiple oral administrations to healthy volunteers. J Clin Pharmacol. 2002 Jul;42(7):782-90. DM2438J RU https://pubmed.ncbi.nlm.nih.gov/12092745 DMBSHJ6 DI DMBSHJ6 DMBSHJ6 DN Zabiciprilat DMBSHJ6 MI TTL69WB DMBSHJ6 MN Angiotensin-converting enzyme (ACE) DMBSHJ6 MT DTT DMBSHJ6 MA Inhibitor DMBSHJ6 RN Enzyme immunoassays for a new angiotensin-converting enzyme inhibitor, zabicipril, and its active metabolite in human plasma: application to pharmacokinetic studies. Ther Drug Monit. 1993 Oct;15(5):448-54. DMBSHJ6 RU https://pubmed.ncbi.nlm.nih.gov/8249053 DM9F650 DI DM9F650 DM9F650 DN ZANKIREN DM9F650 MI TTB2MXP DM9F650 MN Angiotensinogenase renin (REN) DM9F650 MT DTT DM9F650 MA Inhibitor DM9F650 RN Design and preparation of potent, nonpeptidic, bioavailable renin inhibitors. J Med Chem. 2009 Jun 25;52(12):3689-702. DM9F650 RU https://pubmed.ncbi.nlm.nih.gov/19358611 DMS95DX DI DMS95DX DMS95DX DN ZD-0947 DMS95DX MI TT1VOHK DMS95DX MN Potassium channel unspecific (KC) DMS95DX MT DTT DMS95DX MA Opener DMS95DX RN Effects of ZD6169 and ZD0947, 2 potassium adenosine triphosphate channel openers, on bladder function of spinalized rats. J Urol. 2002 Aug;168(2):837-42. DMS95DX RU https://pubmed.ncbi.nlm.nih.gov/12131377 DMVFCX7 DI DMVFCX7 DMVFCX7 DN ZD-2138 DMVFCX7 MI TTSJ6Q4 DMVFCX7 MN LOX-5 messenger RNA (ALOX5 mRNA) DMVFCX7 MT DTT DMVFCX7 MA Inhibitor DMVFCX7 RN Synthesis and biological activity of N-aroyl-tetrahydro-gamma-carbolines. Bioorg Med Chem. 2010 Jun 1;18(11):3910-24. DMVFCX7 RU https://pubmed.ncbi.nlm.nih.gov/20451397 DMLFNMB DI DMLFNMB DMLFNMB DN ZD-2486 DMLFNMB MI TT38RM1 DMLFNMB MN Glycoprotein IIb/IIIa receptor (GPIIb/IIIa) DMLFNMB MT DTT DMLFNMB MA Modulator DMLFNMB RN Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41. DMLFNMB RU https://www.ncbi.nlm.nih.gov/pubmed/15950434 DM5UCHW DI DM5UCHW DM5UCHW DN ZD-4953 DM5UCHW MI TT9B4N3 DM5UCHW MN Prostaglandin receptor (PTGR) DM5UCHW MT DTT DM5UCHW MA Modulator DM5UCHW RN WO patent application no. 2013,1675,82, Methods and pharmaceutical compositions for prevention or treatment of chronic obstructive pulmonary disease. DM5UCHW RU http://worldwide.espacenet.com/publicationDetails/biblio?DB=worldwide.espacenet.com&II=0&ND=3&adjacent=true&locale=en_EP&FT=D&date=20131114&CC=WO&NR=2013167582A1&KC=A1 DMVBL25 DI DMVBL25 DMVBL25 DN ZD-6169 DMVBL25 MI TT1VOHK DMVBL25 MN Potassium channel unspecific (KC) DMVBL25 MT DTT DMVBL25 MA Opener DMVBL25 RN Effects of ZD6169 and ZD0947, 2 potassium adenosine triphosphate channel openers, on bladder function of spinalized rats. J Urol. 2002 Aug;168(2):837-42. DMVBL25 RU https://pubmed.ncbi.nlm.nih.gov/12131377 DM46JIR DI DM46JIR DM46JIR DN ZD6416 DM46JIR MI TTG1QMU DM46JIR MN Prostaglandin E2 receptor EP1 (PTGER1) DM46JIR MT DTT DM46JIR MA Antagonist DM46JIR RN The prostaglandin E2 receptor-1 (EP-1) mediates acid-induced visceral pain hypersensitivity in humans. Gastroenterology. 2003 Jan;124(1):18-25. DM46JIR RU https://pubmed.ncbi.nlm.nih.gov/12512025 DMBSXPJ DI DMBSXPJ DMBSXPJ DN ZD-8321 DMBSXPJ MI TTPLTSQ DMBSXPJ MN Neutrophil elastase (NE) DMBSXPJ MT DTT DMBSXPJ MA Inhibitor DMBSXPJ RN Neutrophil elastase inhibitors as treatment for COPD. Expert Opin Investig Drugs. 2002 Jul;11(7):965-80. DMBSXPJ RU https://pubmed.ncbi.nlm.nih.gov/12084007 DM1QXPE DI DM1QXPE DM1QXPE DN ZELANDOPAM HYDROCHLORIDE DM1QXPE MI TTZFYLI DM1QXPE MN Dopamine D1 receptor (D1R) DM1QXPE MT DTT DM1QXPE MA Antagonist DM1QXPE RN Effect of zelandopam, a dopamine D1-like receptor agonist, in puromycin aminonucleoside nephrosis rats. Eur J Pharmacol. 2005 Mar 7;510(1-2):121-6. DM1QXPE RU https://pubmed.ncbi.nlm.nih.gov/15740732 DMC6H4Y DI DMC6H4Y DMC6H4Y DN ZIFROSILONE DMC6H4Y MI TT1RS9F DMC6H4Y MN Acetylcholinesterase (AChE) DMC6H4Y MT DTT DMC6H4Y MA Inhibitor DMC6H4Y RN Acetylcholinesterase inhibition by zifrosilone: pharmacokinetics and pharmacodynamics. Clin Pharmacol Ther. 1995 Jul;58(1):54-61. DMC6H4Y RU https://pubmed.ncbi.nlm.nih.gov/7628183 DM3IRES DI DM3IRES DM3IRES DN Zilascorb (2H) DM3IRES MI TTLIZBJ DM3IRES MN Protein synthesis (hPRO synth) DM3IRES MT DTT DM3IRES MA Modulator DM3IRES RN Zilascorb(2H), a new reversible protein synthesis inhibitor: clinical study of an oral preparation. Anticancer Drugs. 1997 Mar;8(3):296-303. DM3IRES RU https://pubmed.ncbi.nlm.nih.gov/9095337 DM9FQI0 DI DM9FQI0 DM9FQI0 DN Zolasartan DM9FQI0 MI TT8DBY3 DM9FQI0 MN Angiotensin II receptor type-1 (AGTR1) DM9FQI0 MT DTT DM9FQI0 MA Agonist DM9FQI0 RN Azilsartan: a newly approved angiotensin II receptor blocker. Cardiol Rev. 2011 Nov-Dec;19(6):300-4. DM9FQI0 RU https://pubmed.ncbi.nlm.nih.gov/21983318 DMWOT92 DI DMWOT92 DMWOT92 DN ZOPOLRESTAT DMWOT92 MI TTFBNVI DMWOT92 MN Aldose reductase (AKR1B1) DMWOT92 MT DTT DMWOT92 MA Modulator DMWOT92 RN Comparison of the effects of Zopolrestat and Sorbinil on lens myo-inositol influx. Pharmacology. 1997 Feb;54(2):76-83. DMWOT92 RU https://www.ncbi.nlm.nih.gov/pubmed/9088040 DMB8XJM DI DMB8XJM DMB8XJM DN AD-121 DMB8XJM MI TTPNQAC DMB8XJM MN Estrogen-related receptor-alpha (ESRRA) DMB8XJM MT DTT DMB8XJM MA Modulator DMB8XJM RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 622). DMB8XJM RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=622 DMR8XEN DI DMR8XEN DMR8XEN DN AME-527 DMR8XEN MI TTF8CQI DMR8XEN MN Tumor necrosis factor (TNF) DMR8XEN MT DTT DMR8XEN RN IND Filed for AME-527, Monoclonal Antibody That Is a Potential Treatment for Rheumatoid Arthritis. P&T Community. 2015. DMR8XEN RU http://ww.ptjournal.com/news/2003-11-26-000000/ind-filed-ame-527-monoclonal-antibody-potential-treatment-rheumatoid DM3P84V DI DM3P84V DM3P84V DN AVE-5883 DM3P84V MI TTYO0A3 DM3P84V MN Substance-K receptor (TACR2) DM3P84V MT DTT DM3P84V MA Modulator DM3P84V RN Effect of an NK1/NK2 receptor antagonist on airway responses and inflammation to allergen in asthma. Am J Respir Crit Care Med. 2007 Mar 1;175(5):450-7. DM3P84V RU https://pubmed.ncbi.nlm.nih.gov/17170385 DM3P84V DI DM3P84V DM3P84V DN AVE-5883 DM3P84V MI TTZPO1L DM3P84V MN Substance-P receptor (TACR1) DM3P84V MT DTT DM3P84V MA Modulator DM3P84V RN Effect of an NK1/NK2 receptor antagonist on airway responses and inflammation to allergen in asthma. Am J Respir Crit Care Med. 2007 Mar 1;175(5):450-7. DM3P84V RU https://pubmed.ncbi.nlm.nih.gov/17170385 DMGEDAY DI DMGEDAY DMGEDAY DN AVI-4065 DMGEDAY MI TT20AHC DMGEDAY MN Hepatitis C virus NS3 helicase messenger RNA (HCV NS3 mRNA) DMGEDAY MT DTT DMGEDAY RN Design and development of antisense drugs. Expert Opin. Drug Discov. 2008 3(10):1189-1207. DMGEDAY RU http://www.informahealthcare.com/doi/abs/10.1517/17460441.3.10.1177 DM7L8SG DI DM7L8SG DM7L8SG DN AZD8055 DM7L8SG MI TTCJG29 DM7L8SG MN Serine/threonine-protein kinase mTOR (mTOR) DM7L8SG MT DTT DM7L8SG MA Inhibitor DM7L8SG RN Clinical pipeline report, company report or official report of AstraZeneca (2009). DM7L8SG RU http://www.astrazeneca.com/_mshost3690701/content/resources/media/investors/AZN-Q2-2009/AZN-Q2-2009-Pipeline.pdf DMJTB4E DI DMJTB4E DMJTB4E DN CDP-484 DMJTB4E MI TTRYK0X DMJTB4E MN Interleukin-1 beta (IL1B) DMJTB4E MT DTT DMJTB4E MA Inhibitor DMJTB4E RN Biological targets for therapeutic interventions in COPD: clinical potential. Int J Chron Obstruct Pulmon Dis. 2006 September; 1(3): 321-334. DMJTB4E RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2707155/ DMMZ79C DI DMMZ79C DMMZ79C DN CER-227185 DMMZ79C MI TT3PTB6 DMMZ79C MN Translationally-controlled tumor protein (TPT1) DMMZ79C MT DTT DMMZ79C MA Inhibitor DMMZ79C RN Clinical pipeline report, company report or official report of Cerep. DMMZ79C RU http://www.cerep.fr/Cerep/Users/pages/News/PressReleases/2006/215.pdf DMH40I3 DI DMH40I3 DMH40I3 DN CM-GLP-1 DMH40I3 MI TTVIMDE DMH40I3 MN Glucagon-like peptide 1 receptor (GLP1R) DMH40I3 MT DTT DMH40I3 MA Modulator DMH40I3 RN Reversal of diabetes in rats using GLP-1-expressing adult pancreatic duct-like precursor cells transformed from acinar to ductal cells. Stem Cells Dev. 2009 Sep;18(7):991-1002. DMH40I3 RU https://pubmed.ncbi.nlm.nih.gov/19125629 DMKFIBH DI DMKFIBH DMKFIBH DN CYT-007-TNFQb DMKFIBH MI TTF8CQI DMKFIBH MN Tumor necrosis factor (TNF) DMKFIBH MT DTT DMKFIBH MA Inhibitor DMKFIBH RN Therapeutic Vaccination with TNF-Kinoid in TNF Antagonist-Resistant Rheumatoid Arthritis: A Phase II Randomized, Controlled Clinical Trial. PLoS One. 2014; 9(12): e113465. DMKFIBH RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4269456/ DMCWRYS DI DMCWRYS DMCWRYS DN CYT-009-GhrQb DMCWRYS MI TTWDC17 DMCWRYS MN Growth hormone secretagogue receptor 1 (GHSR) DMCWRYS MT DTT DMCWRYS MA Antagonist DMCWRYS RN Emerging drugs for obesity: linking novel biological mechanisms to pharmaceutical pipelines. Expert Opin Emerg Drugs. 2005 Aug;10(3):643-60. DMCWRYS RU https://pubmed.ncbi.nlm.nih.gov/16083333 DM17GMN DI DM17GMN DM17GMN DN EG-011 DM17GMN MI TTOM5H4 DM17GMN MN Vascular endothelial growth factor D (VEGFD) DM17GMN MT DTT DM17GMN MA Modulator DM17GMN RN Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800030807) DM17GMN RU http://adisinsight.springer.com/drugs/800030807 DM7JMVR DI DM7JMVR DM7JMVR DN EG-016 DM7JMVR MI TTOM5H4 DM7JMVR MN Vascular endothelial growth factor D (VEGFD) DM7JMVR MT DTT DM7JMVR MA Modulator DM7JMVR RN Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800030807) DM7JMVR RU http://adisinsight.springer.com/drugs/800030807 DMB35UN DI DMB35UN DMB35UN DN FGF-21 DMB35UN MI TTQ916P DMB35UN MN Fibroblast growth factor-21 (FGF21) DMB35UN MT DTT DMB35UN MA Agonist DMB35UN RN Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800028644) DMB35UN RU http://adisinsight.springer.com/drugs/800028644 DMYR7LO DI DMYR7LO DMYR7LO DN GPG DMYR7LO MI TTEC2T3 DMYR7LO MN Human immunodeficiency virus Envelope glycoprotein gp160 (HIV env) DMYR7LO MT DTT DMYR7LO MA Inhibitor DMYR7LO RN GPG-NH2 acts via the metabolite alphaHGA to target HIV-1 Env to the ER-associated protein degradation pathway. Retrovirology 2010, 7:20. DMYR7LO RU http://www.retrovirology.com/content/7/1/20 DM7R126 DI DM7R126 DM7R126 DN GS-9005 DM7R126 MI TT5FNQT DM7R126 MN Human immunodeficiency virus Protease (HIV PR) DM7R126 MT DTT DM7R126 MA Inhibitor DM7R126 RN WO patent application no. 2003,0906,90, Cellular accumulation of phosphonate analogs of hiv protease inhibitor compounds and the compounds as such. DM7R126 RU http://www.google.com/patents/WO2003090690A2?cl=pt DMXB4T9 DI DMXB4T9 DMXB4T9 DN GS-9132 DMXB4T9 MI TTRHUKY DMXB4T9 MN Hepatitis C virus Serine protease NS4A (HCV NS4A) DMXB4T9 MT DTT DMXB4T9 MA Modulator DMXB4T9 RN Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41. DMXB4T9 RU https://www.ncbi.nlm.nih.gov/pubmed/15950434 DM9AOJT DI DM9AOJT DM9AOJT DN HuM-195-Bi-213 DM9AOJT MI TTJVYO3 DM9AOJT MN Myeloid cell surface antigen CD33 (CD33) DM9AOJT MT DTT DM9AOJT MA Inhibitor DM9AOJT RN Sequential cytarabine and alpha-particle immunotherapy with bismuth-213-lintuzumab (HuM195) for acute myeloid leukemia. Clin Cancer Res. 2010 Nov 1;16(21):5303-11. DM9AOJT RU https://pubmed.ncbi.nlm.nih.gov/20858843 DMAYLS3 DI DMAYLS3 DMAYLS3 DN IDX-320 DMAYLS3 MI TTRHUKY DMAYLS3 MN Hepatitis C virus Serine protease NS4A (HCV NS4A) DMAYLS3 MT DTT DMAYLS3 MA Modulator DMAYLS3 RN Rapid decline of viral RNA in chronic hepatitis C patients treated once daily with IDX320: a novel macrocyclic HCV protease inhibitor.Antivir Ther.2012;17(4):633-42. DMAYLS3 RU https://www.ncbi.nlm.nih.gov/pubmed/22427481 DMEF9JW DI DMEF9JW DMEF9JW DN IM0-8400 DMEF9JW MI TTRJ1K4 DMEF9JW MN Toll-like receptor 7 (TLR7) DMEF9JW MT DTT DMEF9JW MA Antagonist DMEF9JW RN Clinical pipeline report, company report or official report of Idera Pharmaceuticals. DMEF9JW RU http://www.iderapharma.com/pipeline DMEF9JW DI DMEF9JW DMEF9JW DN IM0-8400 DMEF9JW MI TT8CWFK DMEF9JW MN Toll-like receptor 8 (TLR8) DMEF9JW MT DTT DMEF9JW MA Antagonist DMEF9JW RN Clinical pipeline report, company report or official report of Idera Pharmaceuticals. DMEF9JW RU http://www.iderapharma.com/pipeline DMEF9JW DI DMEF9JW DMEF9JW DN IM0-8400 DMEF9JW MI TTSHG0T DMEF9JW MN Toll-like receptor 9 (TLR9) DMEF9JW MT DTT DMEF9JW MA Antagonist DMEF9JW RN Clinical pipeline report, company report or official report of Idera Pharmaceuticals. DMEF9JW RU http://www.iderapharma.com/pipeline DMMJC4Q DI DMMJC4Q DMMJC4Q DN KSB-303 DMMJC4Q MI TTY6DTE DMMJC4Q MN Carcinoembryonic antigen CEA (CD66e) DMMJC4Q MT DTT DMMJC4Q RN Anticancer Antibodies. (2003) American Journal of Clinical Pathology, 119, 472-485. DMMJC4Q RU http://ajcp.ascpjournals.org/content/119/4/472.full.pdf DM7QGSX DI DM7QGSX DM7QGSX DN KW-2450 DM7QGSX MI TTCBFJO DM7QGSX MN Insulin receptor (INSR) DM7QGSX MT DTT DM7QGSX MA Modulator DM7QGSX RN Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41. DM7QGSX RU https://www.ncbi.nlm.nih.gov/pubmed/15950434 DM7QGSX DI DM7QGSX DM7QGSX DN KW-2450 DM7QGSX MI TTHRID2 DM7QGSX MN Insulin-like growth factor I receptor (IGF1R) DM7QGSX MT DTT DM7QGSX MA Modulator DM7QGSX RN Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41. DM7QGSX RU https://www.ncbi.nlm.nih.gov/pubmed/15950434 DMXB20Y DI DMXB20Y DMXB20Y DN MDX-214 DMXB20Y MI TTGUJAO DMXB20Y MN Immunoglobulin alpha Fc receptor (FCAR) DMXB20Y MT DTT DMXB20Y RN A phase I, pharmacokinetic (PK) and pharmacodynamic (PD) study of MDX-214, a novel immune-mediated mechanism agent targeting the epithelial growth factor receptor (EGFR), in patients with advanced solid tumors. Journal of Clinical Oncology, Vol 24, No 18S (June 20 Supplement), 2006: 2523. DMXB20Y RU http://meeting.ascopubs.org/cgi/content/short/24/18_suppl/2523 DMNXCFZ DI DMNXCFZ DMNXCFZ DN NCX 950 DMNXCFZ MI TTMXGCW DMNXCFZ MN Adrenergic receptor beta-3 (ADRB3) DMNXCFZ MT DTT DMNXCFZ MA Agonist DMNXCFZ RN A Nitric Oxide-Releasing Salbutamol Elicits Potent Relaxant and Anti-Inflammatory Activities. JPET July 2004 vol. 310 no. 1 367-375. DMNXCFZ RU http://jpet.aspetjournals.org/content/310/1/367.abstract DMO34NQ DI DMO34NQ DMO34NQ DN PD-151832 DMO34NQ MI TTZ9SOR DMO34NQ MN Muscarinic acetylcholine receptor M1 (CHRM1) DMO34NQ MT DTT DMO34NQ MA Agonist DMO34NQ RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015 DMO34NQ RU https://www.accessdata.fda.gov/scripts/cder/drugsatfda/ DMRQPOD DI DMRQPOD DMRQPOD DN R-803 DMRQPOD MI TTMVBWH DMRQPOD MN Hepatitis C virus RNA-directed RNA polymerase (HCV NS5B) DMRQPOD MT DTT DMRQPOD MA Modulator DMRQPOD RN Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41. DMRQPOD RU https://www.ncbi.nlm.nih.gov/pubmed/15950434 DMIAZJ9 DI DMIAZJ9 DMIAZJ9 DN RhApo2L/TRAIL DMIAZJ9 MI TT5WLRX DMIAZJ9 MN TRAIL receptor 1 (TRAIL-R1) DMIAZJ9 MT DTT DMIAZJ9 MA Agonist DMIAZJ9 RN Clinical pipeline report, company report or official report of Amgen (2009). DMIAZJ9 RU http://www.amgen.com/science/pipe.jsp DMIAZJ9 DI DMIAZJ9 DMIAZJ9 DN RhApo2L/TRAIL DMIAZJ9 MI TTW20TU DMIAZJ9 MN TRAIL receptor 2 (TRAIL-R2) DMIAZJ9 MT DTT DMIAZJ9 MA Agonist DMIAZJ9 RN Clinical pipeline report, company report or official report of Amgen (2009). DMIAZJ9 RU http://www.amgen.com/science/pipe.jsp DMHXRZF DI DMHXRZF DMHXRZF DN UK-369003 DMHXRZF MI TTJ0IQB DMHXRZF MN Phosphodiesterase 5A (PDE5A) DMHXRZF MT DTT DMHXRZF MA Inhibitor DMHXRZF RN Pfizer. Product Development Pipeline. March 31 2009. DMHXRZF RU http://media.pfizer.com/files/research/pipeline/2009_0331/pipeline_2009_0331.pdf DM8Q2ZR DI DM8Q2ZR DM8Q2ZR DN WX-UK1 DM8Q2ZR MI TTGY7WI DM8Q2ZR MN Urokinase-type plasminogen activator (PLAU) DM8Q2ZR MT DTT DM8Q2ZR MA Inhibitor DM8Q2ZR RN Inhibition of the invasion capacity of carcinoma cells by WX-UK1, a novel synthetic inhibitor of the urokinase-type plasminogen activator system. Int J Cancer. 2004 Jul 20;110(6):815-24. DM8Q2ZR RU https://pubmed.ncbi.nlm.nih.gov/15170662 DMC7M3K DI DMC7M3K DMC7M3K DN 447C88 DMC7M3K MI TTMF541 DMC7M3K MN Liver carboxylesterase (CES1) DMC7M3K MT DTT DMC7M3K MA Modulator DMC7M3K RN The tolerability, pharmacokinetics and lack of effect on plasma cholesterol of 447C88, an AcylCoA: Cholesterol Acyl Transferase (ACAT) inhibitor with low bioavailability, in healthy volunteers. Eur JClin Pharmacol. 1995;49(3):243-9. DMC7M3K RU https://pubmed.ncbi.nlm.nih.gov/8666002 DMHT84I DI DMHT84I DMHT84I DN A-216546 DMHT84I MI TTKRD0G DMHT84I MN Endothelin A receptor (EDNRA) DMHT84I MT DTT DMHT84I MA Antagonist DMHT84I RN Pharmacology of A-216546: a highly selective antagonist for endothelin ET(A) receptor. Eur J Pharmacol. 1999 Feb 5;366(2-3):189-201. DMHT84I RU https://pubmed.ncbi.nlm.nih.gov/10082200 DM0DLC1 DI DM0DLC1 DM0DLC1 DN A-75998 DM0DLC1 MI TT8R70G DM0DLC1 MN Gonadotropin-releasing hormone receptor (GNRHR) DM0DLC1 MT DTT DM0DLC1 MA Antagonist DM0DLC1 RN Physicochemical properties of A-75998, an antagonist of luteinizing hormone releasing hormone. J Pharm Sci. 1995 Aug;84(8):953-8. DM0DLC1 RU https://pubmed.ncbi.nlm.nih.gov/7500280 DMGEWQ7 DI DMGEWQ7 DMGEWQ7 DN A-80987 DMGEWQ7 MI TT5FNQT DMGEWQ7 MN Human immunodeficiency virus Protease (HIV PR) DMGEWQ7 MT DTT DMGEWQ7 MA Inhibitor DMGEWQ7 RN Human serum alpha 1 acid glycoprotein reduces uptake, intracellular concentration, and antiviral activity of A-80987, an inhibitor of the human immunodeficiency virus type 1 protease. Antimicrob Agents Chemother. 1996 Jun;40(6):1491-7. DMGEWQ7 RU https://pubmed.ncbi.nlm.nih.gov/8726025 DMJTIUP DI DMJTIUP DMJTIUP DN ABJ-879 DMJTIUP MI TTML2WA DMJTIUP MN Tubulin (TUB) DMJTIUP MT DTT DMJTIUP MA Modulator DMJTIUP RN Novel tubulin-targeting agents: anticancer activity and pharmacologic profile of epothilones and related analogues. Ann Oncol. 2007 Jul;18 Suppl 5:v9-15. DMJTIUP RU https://pubmed.ncbi.nlm.nih.gov/17656562 DMADKHB DI DMADKHB DMADKHB DN ABN-912 DMADKHB MI TTNAY0P DMADKHB MN Monocyte chemotactic and activating factor (CCL2) DMADKHB MT DTT DMADKHB RN A randomized controlled trial with an anti-CCL2 (anti-monocyte chemotactic protein 1) monoclonal antibody in patients with rheumatoid arthritis. Arthritis Rheum. 2006 Aug;54(8):2387-92. DMADKHB RU https://pubmed.ncbi.nlm.nih.gov/16869001 DMTYWE9 DI DMTYWE9 DMTYWE9 DN ABT-080 DMTYWE9 MI TTTWGIX DMTYWE9 MN Leukotriene receptor (LTR) DMTYWE9 MT DTT DMTYWE9 MA Modulator DMTYWE9 RN An update on the role of leukotrienes in asthma. Curr Opin Allergy Clin Immunol. 2010 February; 10(1): 60-66. DMTYWE9 RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2838730/ DMPCYV6 DI DMPCYV6 DMPCYV6 DN ABT-107 DMPCYV6 MI TTLA931 DMPCYV6 MN Neuronal acetylcholine receptor alpha-7 (CHRNA7) DMPCYV6 MT DTT DMPCYV6 MA Modulator DMPCYV6 RN In vitro pharmacological characterization of a novel selective alpha7 neuronal nicotinic acetylcholine receptor agonist ABT-107. J Pharmacol Exp Ther. 2010 Sep 1;334(3):863-74. DMPCYV6 RU https://pubmed.ncbi.nlm.nih.gov/20504915 DMG9Y80 DI DMG9Y80 DMG9Y80 DN ABT-202 DMG9Y80 MI TTJSZTB DMG9Y80 MN Nicotinic acetylcholine receptor (nAChR) DMG9Y80 MT DTT DMG9Y80 MA Modulator DMG9Y80 RN Modulators of nicotinic acetylcholine receptors as analgesics. Curr Opin Investig Drugs. 2004 Jan;5(1):76-81. DMG9Y80 RU https://pubmed.ncbi.nlm.nih.gov/14983978 DMWVFDH DI DMWVFDH DMWVFDH DN ABT-279 DMWVFDH MI TTDIGC1 DMWVFDH MN Dipeptidyl peptidase 4 (DPP-4) DMWVFDH MT DTT DMWVFDH MA Inhibitor DMWVFDH RN Emerging drug candidates of dipeptidyl peptidase IV (DPP IV) inhibitor class for the treatment of Type 2 Diabetes. Curr Drug Targets. 2009 Jan;10(1):71-87. DMWVFDH RU https://pubmed.ncbi.nlm.nih.gov/19149538 DM8GZAS DI DM8GZAS DM8GZAS DN ABT-299 DM8GZAS MI TTQL5VC DM8GZAS MN Platelet-activating factor receptor (PTAFR) DM8GZAS MT DTT DM8GZAS MA Antagonist DM8GZAS RN ABT-299, a novel PAF antagonist, attenuates multiple effects of endotoxemia in conscious rats. Shock. 1996 Aug;6(2):112-7. DM8GZAS RU https://pubmed.ncbi.nlm.nih.gov/8856845 DMA2RM3 DI DMA2RM3 DMA2RM3 DN ABT-518 DMA2RM3 MI TT1GHVO DMA2RM3 MN Matrix metalloproteinase (MMP) DMA2RM3 MT DTT DMA2RM3 MA Inhibitor DMA2RM3 RN Quantitative analysis of the novel anticancer drug ABT-518, a matrix metalloproteinase inhibitor, plus the screening of six metabolites in human plasma using high-performance liquid chromatography coupled with electrospray tandem mass spectrometry. J Mass Spectrom. 2004 Mar;39(3):277-88. DMA2RM3 RU https://pubmed.ncbi.nlm.nih.gov/15039935 DMZYVPB DI DMZYVPB DMZYVPB DN ABX-MA1 DMZYVPB MI TTD26RC DMZYVPB MN Cell adhesion molecule (CADM) DMZYVPB MT DTT DMZYVPB RN Fully human antibodies to MCAM/MUC18 inhibit tumor growth and metastasis of human melanoma. Cancer Res. 2002 Sep 1;62(17):5106-14. DMZYVPB RU https://pubmed.ncbi.nlm.nih.gov/12208768 DME98LV DI DME98LV DME98LV DN AC-162352 DME98LV MI TTJ6WK9 DME98LV MN Neuropeptide Y receptor type 2 (NPY2R) DME98LV MT DTT DME98LV MA Agonist DME98LV RN Emerging drugs for obesity: linking novel biological mechanisms to pharmaceutical pipelines. Expert Opin Emerg Drugs. 2005 Aug;10(3):643-60. DME98LV RU https://pubmed.ncbi.nlm.nih.gov/16083333 DM704HO DI DM704HO DM704HO DN AC-253 DM704HO MI TTAT87F DM704HO MN Amylin receptor (IAPPR) DM704HO MT DTT DM704HO MA Antagonist DM704HO RN Biotechnology and Its Application in Pharmacy. Kulkarn. 2002. Page157. DM704HO RU https://books.google.com.hk/books?id=cw7bgQnWz9YC&pg=PA157&lpg=PA157&dq=AC-625+++Amylin+receptor&source=bl&ots=sLtM1OBea8&sig=MvdugRHN-VfgpBV2ac2K8BTY7d8&hl=zh-CN&sa=X&ved=0CCQQ6AEwAWoVChMIv7Wi4vS2yAIVDhuOCh3wKgMe#v=onepage&q=AC-625%20%20%20Amylin%20receptor&f=false DM54W9A DI DM54W9A DM54W9A DN AC3056 DM54W9A MI TTC0BEN DM54W9A MN Oxidative stress (OS) DM54W9A MT DTT DM54W9A MA Inhibitor DM54W9A RN The novel antioxidant, AC3056 (2,6-di-t-butyl-4-((dimethyl-4-methoxyphenylsilyl)methyloxy)phenol), reverses erectile dysfunction in diabetic rats and improves NO-mediated responses in penile tissue from diabetic men. J Sex Med. 2009 Feb;6(2):373-87. DM54W9A RU https://pubmed.ncbi.nlm.nih.gov/19040617 DMIJB68 DI DMIJB68 DMIJB68 DN AC-625 DMIJB68 MI TTAT87F DMIJB68 MN Amylin receptor (IAPPR) DMIJB68 MT DTT DMIJB68 MA Modulator DMIJB68 RN Biotechnology and Its Application in Pharmacy. Kulkarn. 2002. Page157. DMIJB68 RU https://books.google.com.hk/books?id=cw7bgQnWz9YC&pg=PA157&lpg=PA157&dq=AC-625+++Amylin+receptor&source=bl&ots=sLtM1OBea8&sig=MvdugRHN-VfgpBV2ac2K8BTY7d8&hl=zh-CN&sa=X&ved=0CCQQ6AEwAWoVChMIv7Wi4vS2yAIVDhuOCh3wKgMe#v=onepage&q=AC-625%20%20%20Amylin%20receptor&f=false DMSPW3N DI DMSPW3N DMSPW3N DN ACH-2928 DMSPW3N MI TTCJ2X8 DMSPW3N MN Hepatitis C virus Non-structural 5A (HCV NS5A) DMSPW3N MT DTT DMSPW3N MA Modulator DMSPW3N RN Company report (Achillion) DMSPW3N RU http://ir.achillion.com/releasedetail.cfm?releaseid=629849 DML1AUZ DI DML1AUZ DML1AUZ DN ADL-7445 DML1AUZ MI TTKWM86 DML1AUZ MN Opioid receptor mu (MOP) DML1AUZ MT DTT DML1AUZ MA Antagonist DML1AUZ RN Novel opioid antagonists for opioid-induced bowel dysfunction. Expert Opin Investig Drugs. 2011 Aug;20(8):1047-56. DML1AUZ RU https://pubmed.ncbi.nlm.nih.gov/21663526 DMRSEZD DI DMRSEZD DMRSEZD DN AE-3763 DMRSEZD MI TTPLTSQ DMRSEZD MN Neutrophil elastase (NE) DMRSEZD MT DTT DMRSEZD MA Inhibitor DMRSEZD RN Neutrophil elastase inhibitors as treatment for COPD. Expert Opin Investig Drugs. 2002 Jul;11(7):965-80. DMRSEZD RU https://pubmed.ncbi.nlm.nih.gov/12084007 DM1TYM4 DI DM1TYM4 DM1TYM4 DN AG-021541 DM1TYM4 MI TTMVBWH DM1TYM4 MN Hepatitis C virus RNA-directed RNA polymerase (HCV NS5B) DM1TYM4 MT DTT DM1TYM4 MA Inhibitor DM1TYM4 RN Emerging drugs for hepatitis C. Expert Opin Emerg Drugs. 2008 Mar;13(1):1-19. DM1TYM4 RU https://pubmed.ncbi.nlm.nih.gov/18321145 DMCEM0L DI DMCEM0L DMCEM0L DN AG-331 DMCEM0L MI TTU6BFZ DMCEM0L MN Candida Thymidylate synthase (Candi TMP1) DMCEM0L MT DTT DMCEM0L MA Inhibitor DMCEM0L RN Phase I trial of the thymidylate synthase inhibitor AG331 as a 5-day continuous infusion. Clin Cancer Res. 1996 Oct;2(10):1685-92. DMCEM0L RU https://pubmed.ncbi.nlm.nih.gov/9816117 DM8XODL DI DM8XODL DM8XODL DN AGN-191743 DM8XODL MI TTQL5VC DM8XODL MN Platelet-activating factor receptor (PTAFR) DM8XODL MT DTT DM8XODL MA Modulator DM8XODL RN US patent application no. 6,274,627, Conjugates of dithiocarbamate disulfides with pharmacologically active agents and uses therefor. DM8XODL RU http://www.google.com/patents/US6274627 DMGAERX DI DMGAERX DMGAERX DN AIR-Epinephrine DMGAERX MI TTVIREA DMGAERX MN Adrenergic receptor (ADR) DMGAERX MT DTT DMGAERX MA Agonist DMGAERX RN Prostaglandin synthesis inhibitors reverse alpha-adrenergic inhibition of acute insulin response to glucose. Am J Physiol. 1980 Dec;239(6):E490-500. DMGAERX RU https://pubmed.ncbi.nlm.nih.gov/6255805 DMVBKLO DI DMVBKLO DMVBKLO DN ALBIFYLLINE DMVBKLO MI TTUST1O DMVBKLO MN Phosphodiesterase (PDE) DMVBKLO MT DTT DMVBKLO MA Inhibitor DMVBKLO RN Enhanced tumor necrosis factor suppression and cyclic adenosine monophosphate accumulation by combination of phosphodiesterase inhibitors and prostanoids. Eur J Immunol. 1995 Jan;25(1):147-53. DMVBKLO RU https://pubmed.ncbi.nlm.nih.gov/7843225 DM2QMKJ DI DM2QMKJ DM2QMKJ DN ALS-00T2-0501 DM2QMKJ MI TTF8CQI DM2QMKJ MN Tumor necrosis factor (TNF) DM2QMKJ MT DTT DM2QMKJ MA Modulator DM2QMKJ RN Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41. DM2QMKJ RU https://www.ncbi.nlm.nih.gov/pubmed/15950434 DMS5C06 DI DMS5C06 DMS5C06 DN ALTU-237 DMS5C06 MI TTMDQIJ DMS5C06 MN Oxalate absorption (Oxalate absor) DMS5C06 MT DTT DMS5C06 MA Modulator DMS5C06 RN Hyperoxaluria: a gut-kidney axis. Kidney Int. 2011 Dec;80(11):1146-58. DMS5C06 RU https://pubmed.ncbi.nlm.nih.gov/21866092 DMNOZAI DI DMNOZAI DMNOZAI DN ALX-0646 DMNOZAI MI TT6MSOK DMNOZAI MN 5-HT 1D receptor (HTR1D) DMNOZAI MT DTT DMNOZAI MA Agonist DMNOZAI RN Sustained pain relief with dihydroergotamine in migraine is potentially due to persistent binding to 5-HT1B and 5-HT1D receptors. . The Journal of Headache and Pain 201314(Suppl 1):P75. DMNOZAI RU http://www.thejournalofheadacheandpain.com/content/pdf/1129-2377-14-S1-P75.pdf DMO7920 DI DMO7920 DMO7920 DN AM-831 DMO7920 MI TTJQOD7 DMO7920 MN 5-HT 2A receptor (HTR2A) DMO7920 MT DTT DMO7920 MA Agonist DMO7920 RN Clinical pipeline report, company report or official report of Avarx. DMO7920 RU http://www.avarx.com/AvaRx/SubDomains/Company44/Listings/bucket496701808487035926/Public.Listing.display.html DMO7920 DI DMO7920 DMO7920 DN AM-831 DMO7920 MI TTEX248 DMO7920 MN Dopamine D2 receptor (D2R) DMO7920 MT DTT DMO7920 MA Agonist DMO7920 RN Clinical pipeline report, company report or official report of Avarx. DMO7920 RU http://www.avarx.com/AvaRx/SubDomains/Company44/Listings/bucket496701808487035926/Public.Listing.display.html DMO7920 DI DMO7920 DMO7920 DN AM-831 DMO7920 MI TTH18TF DMO7920 MN Muscarinic acetylcholine receptor M5 (CHRM5) DMO7920 MT DTT DMO7920 MA Agonist DMO7920 RN Clinical pipeline report, company report or official report of Avarx. DMO7920 RU http://www.avarx.com/AvaRx/SubDomains/Company44/Listings/bucket496701808487035926/Public.Listing.display.html DMALVX2 DI DMALVX2 DMALVX2 DN AMELTOLIDE DMALVX2 MI TTRK8B9 DMALVX2 MN Sodium channel unspecific (NaC) DMALVX2 MT DTT DMALVX2 MA Modulator DMALVX2 RN Synthesis and pharmacological evaluation of a major metabolite of ameltolide, a potent anticonvulsant. J Med Chem. 1991 Apr;34(4):1253-7. DMALVX2 RU https://pubmed.ncbi.nlm.nih.gov/2016702 DMIKQ40 DI DMIKQ40 DMIKQ40 DN AMG 076 DMIKQ40 MI TTX4RTB DMIKQ40 MN Melanin-concentrating hormone receptor 1 (MCHR1) DMIKQ40 MT DTT DMIKQ40 MA Antagonist DMIKQ40 RN Stereoselective synthesis of a MCHr1 antagonist. J Org Chem. 2007 Dec 7;72(25):9648-55. DMIKQ40 RU https://pubmed.ncbi.nlm.nih.gov/17997573 DMUO3T2 DI DMUO3T2 DMUO3T2 DN AMG 317 DMUO3T2 MI TTDWHC3 DMUO3T2 MN Interleukin 4 receptor alpha (IL4R) DMUO3T2 MT DTT DMUO3T2 MA Antagonist DMUO3T2 RN Clinical pipeline report, company report or official report of Amgen (2009). DMUO3T2 RU http://www.amgen.com/science/pipe.jsp DMFCKJ1 DI DMFCKJ1 DMFCKJ1 DN AMG-221 DMFCKJ1 MI TTN7BL9 DMFCKJ1 MN Corticosteroid 11-beta-dehydrogenase 1 (HSD11B1) DMFCKJ1 MT DTT DMFCKJ1 MA Inhibitor DMFCKJ1 RN Discovery of a potent, orally active 11beta-hydroxysteroid dehydrogenase type 1 inhibitor for clinical study: identification of (S)-2-((1S,2S,4R)-b... J Med Chem. 2010 Jun 10;53(11):4481-7. DMFCKJ1 RU https://pubmed.ncbi.nlm.nih.gov/20465278 DM3HB06 DI DM3HB06 DM3HB06 DN AMG-517 DM3HB06 MI TTMI6F5 DM3HB06 MN Transient receptor potential cation channel V1 (TRPV1) DM3HB06 MT DTT DM3HB06 MA Blocker DM3HB06 RN Analgesic potential of TRPV1 antagonists. Biochem Pharmacol. 2009 Aug 1;78(3):211-6. DM3HB06 RU https://pubmed.ncbi.nlm.nih.gov/19481638 DMFR3PD DI DMFR3PD DMFR3PD DN ANA-975 DMFR3PD MI TTRJ1K4 DMFR3PD MN Toll-like receptor 7 (TLR7) DMFR3PD MT DTT DMFR3PD MA Agonist DMFR3PD RN Discovery of ANA975: an oral prodrug of the TLR-7 agonist isatoribine. Nucleosides Nucleotides Nucleic Acids. 2007;26(6-7):635-40. DMFR3PD RU https://pubmed.ncbi.nlm.nih.gov/18066870 DMRQFIE DI DMRQFIE DMRQFIE DN ANQ-9040 DMRQFIE MI TTJSZTB DMRQFIE MN Nicotinic acetylcholine receptor (nAChR) DMRQFIE MT DTT DMRQFIE MA Modulator DMRQFIE RN Patent US20030087306 A1. DMRQFIE RU http://www.google.com/patents/US20030087306 DM9GSWY DI DM9GSWY DM9GSWY DN Anthrax vaccine DM9GSWY MI TT3YGCD DM9GSWY MN Bacterial Protective antigen (Bact pagA) DM9GSWY MT DTT DM9GSWY RN Annual Reports in Medicinal Chemistry. Annette M. Doherty. 2005. Page(214). DM9GSWY RU https://books.google.com.hk/books?id=TRA7aZ90tGsC&pg=PA214&lpg=PA214&dq=anthrax+vaccine,+DynPort/AVANT&source=bl&ots=WIkYd7mdbg&sig=8JNU9x-vtT17RRlxsG9FJ0_QZ2c&hl=zh-CN&sa=X&ved=0CBoQ6AEwAGoVChMI2b_539DEyAIVSBiOCh1eBAQb#v=onepage&q=anthrax%20vaccine%2C%20DynPort%2FAVANT&f=false DMN8R2U DI DMN8R2U DMN8R2U DN APD668 DMN8R2U MI TT7QNVC DMN8R2U MN Glucose-dependent insulinotropic receptor (GPR119) DMN8R2U MT DTT DMN8R2U MA Agonist DMN8R2U RN Announces Initiation of Phase 1 Clinical Trial of Arena Type 2 Diabetes Drug Candidate in Collaboration With Ortho-McNeil. Arena Pharmaceuticals, Inc. FEBRUARY 07, 2006. DMN8R2U RU http://www.prnewswire.com/news-releases/arena-pharmaceuticals-inc-announces-initiation-of-phase-1-clinical-trial-of-arena-type-2-diabetes-drug-candidate-in-collaboration-with-ortho-mcneil-55232422.html DM71C6D DI DM71C6D DM71C6D DN Aphidicolin DM71C6D MI TTIU7X1 DM71C6D MN Herpes simplex virus DNA polymerase UL30 (HSV UL30) DM71C6D MT DTT DM71C6D MA Inhibitor DM71C6D RN Proteasome regulation of ULBP1 transcription. J Immunol. 2009 May 15;182(10):6600-9. DM71C6D RU https://pubmed.ncbi.nlm.nih.gov/19414815 DM5L9I2 DI DM5L9I2 DM5L9I2 DN APP-018 DM5L9I2 MI TT7GN3U DM5L9I2 MN Apolipoprotein A-I (APOA1) DM5L9I2 MT DTT DM5L9I2 MA Modulator DM5L9I2 RN Apolipoprotein A-I and its mimetics for the treatment of atherosclerosis. Curr Opin Investig Drugs. 2010 September; 11(9): 989-996. DM5L9I2 RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3074469/ DMRLHNW DI DMRLHNW DMRLHNW DN Aprosulate sodium DMRLHNW MI TTZBFA0 DMRLHNW MN Protease unspecific (PRO) DMRLHNW MT DTT DMRLHNW MA Modulator DMRLHNW RN Interaction between the sulfated lactobionic acid (LW 10082) and other antithrombotic agents in animal thrombosis model. Pol J Pharmacol. 1996 May-Jun;48(3):317-22. DMRLHNW RU https://pubmed.ncbi.nlm.nih.gov/9112669 DMKLCRI DI DMKLCRI DMKLCRI DN ARC-183 DMKLCRI MI TT6L509 DMKLCRI MN Coagulation factor IIa (F2) DMKLCRI MT DTT DMKLCRI RN A high affinity, antidote-controllable prothrombin and thrombin-binding RNA aptamer inhibits thrombin generation and thrombin activity. J Thromb Haemost. 2012 May;10(5):870-80. DMKLCRI RU https://pubmed.ncbi.nlm.nih.gov/22385910 DMHZN42 DI DMHZN42 DMHZN42 DN AR-H049020 DMHZN42 MI TTJ584C DMHZN42 MN Peroxisome proliferator-activated receptor alpha (PPARA) DMHZN42 MT DTT DMHZN42 MA Agonist DMHZN42 RN CN patent application no. 100577175, Combination therapy comprising glucose reabsorption inhibitors and PPAR modulators. DMHZN42 RU http://worldwide.espacenet.com/publicationDetails/biblio?DB=worldwide.espacenet.com&II=0&ND=3&adjacent=true&locale=en_EP&FT=D&date=20050119&CC=CN&NR=1568190A&KC=A DMXD93K DI DMXD93K DMXD93K DN ARRY-614 DMXD93K MI TT9VGXW DMXD93K MN Angiopoietin 1 receptor (TEK) DMXD93K MT DTT DMXD93K MA Modulator DMXD93K RN Cmpany report (Arraybiopharma) DMXD93K RU http://www.arraybiopharma.com/product-pipeline/other-compounds/arry-614/ DMXD93K DI DMXD93K DMXD93K DN ARRY-614 DMXD93K MI TTWELHI DMXD93K MN Stress-activated protein kinase (p38) DMXD93K MT DTT DMXD93K MA Modulator DMXD93K RN Cmpany report (Arraybiopharma) DMXD93K RU http://www.arraybiopharma.com/product-pipeline/other-compounds/arry-614/ DMJDYBX DI DMJDYBX DMJDYBX DN Artilide DMJDYBX MI TTRK8B9 DMJDYBX MN Sodium channel unspecific (NaC) DMJDYBX MT DTT DMJDYBX MA Modulator DMJDYBX RN Potassium channel blockers as antiarrhythmic drugs. Drug Development Research Volume 33, Issue 3, pages 235-249, November 1994. DMJDYBX RU http://onlinelibrary.wiley.com/doi/10.1002/ddr.430330307/abstract DMINF80 DI DMINF80 DMINF80 DN AS-601811 DMINF80 MI TTTU72V DMINF80 MN Steroid 5-alpha-reductase 1 (SRD5A1) DMINF80 MT DTT DMINF80 MA Inhibitor DMINF80 RN Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800013228) DMINF80 RU http://adisinsight.springer.com/drugs/800013228 DMKXDOI DI DMKXDOI DMKXDOI DN AS602868 DMKXDOI MI TT3WG5C DMKXDOI MN Monoamine oxidase type A (MAO-A) DMKXDOI MT DTT DMKXDOI MA Inhibitor DMKXDOI RN Inhibition of rat brain monoamine oxidase activities by psoralen and isopsoralen: implications for the treatment of affective disorders. Pharmacol Toxicol. 2001 Feb;88(2):75-80. DMKXDOI RU https://pubmed.ncbi.nlm.nih.gov/11169165 DMKXDOI DI DMKXDOI DMKXDOI DN AS602868 DMKXDOI MI TTGP7BY DMKXDOI MN Monoamine oxidase type B (MAO-B) DMKXDOI MT DTT DMKXDOI MA Inhibitor DMKXDOI RN Inhibition of rat brain monoamine oxidase activities by psoralen and isopsoralen: implications for the treatment of affective disorders. Pharmacol Toxicol. 2001 Feb;88(2):75-80. DMKXDOI RU https://pubmed.ncbi.nlm.nih.gov/11169165 DMKXDOI DI DMKXDOI DMKXDOI DN AS602868 DMKXDOI MI TTSXVID DMKXDOI MN Nuclear factor NF-kappa-B (NFKB) DMKXDOI MT DTT DMKXDOI MA Inhibitor DMKXDOI RN Emerging therapies for multiple myeloma. Expert Opin Emerg Drugs. 2009 Mar;14(1):99-127. DMKXDOI RU https://pubmed.ncbi.nlm.nih.gov/19249983 DMMPBZF DI DMMPBZF DMMPBZF DN AVE-3247 DMMPBZF MI TTCIHJA DMMPBZF MN Coagulation factor Xa (F10) DMMPBZF MT DTT DMMPBZF MA Inhibitor DMMPBZF RN Semuloparin for the prevention of venous thromboembolic events in cancer patients. Drugs Today (Barc). 2012 Jul;48(7):451-7. DMMPBZF RU https://pubmed.ncbi.nlm.nih.gov/22844656 DM5FDX2 DI DM5FDX2 DM5FDX2 DN AVE-5997EF DM5FDX2 MI TT4C8EA DM5FDX2 MN Dopamine D3 receptor (D3R) DM5FDX2 MT DTT DM5FDX2 MA Antagonist DM5FDX2 RN The pipeline and future of drug development in schizophrenia. Mol Psychiatry. 2007 Oct;12(10):904-22. DM5FDX2 RU https://pubmed.ncbi.nlm.nih.gov/17667958 DMIB3AT DI DMIB3AT DMIB3AT DN AVE-9940 DMIB3AT MI TTWELHI DMIB3AT MN Stress-activated protein kinase (p38) DMIB3AT MT DTT DMIB3AT MA Inhibitor DMIB3AT RN US patent application no. 2008,0119,498, Therapeutic agent for pruritus comprising p38 map kinase inhibitor as the active ingredient. DMIB3AT RU http://worldwide.espacenet.com/publicationDetails/biblio?DB=worldwide.espacenet.com&II=1&ND=3&adjacent=true&locale=en_EP&FT=D&date=20080522&CC=US&NR=2008119498A1&KC=A1 DMTG9EZ DI DMTG9EZ DMTG9EZ DN AWD-140-190 DMTG9EZ MI TTRK8B9 DMTG9EZ MN Sodium channel unspecific (NaC) DMTG9EZ MT DTT DMTG9EZ MA Modulator DMTG9EZ RN Effects of AWD 140-190 on stimulus-induced field potentials and on different patterns of epileptiform activity induced by low calcium or low magnesium in rat entorhinal cortex hippocampal slices. Epilepsy Res. 1997 Dec;29(1):59-69. DMTG9EZ RU https://pubmed.ncbi.nlm.nih.gov/9416460 DM1JN6A DI DM1JN6A DM1JN6A DN Axovan-3 DM1JN6A MI TTY6EWA DM1JN6A MN Neuropeptide Y receptor type 5 (NPY5R) DM1JN6A MT DTT DM1JN6A MA Antagonist DM1JN6A RN Emerging drugs for eating disorder treatment. Expert Opin Emerg Drugs. 2006 May;11(2):315-36. DM1JN6A RU https://pubmed.ncbi.nlm.nih.gov/16634704 DMIM9N1 DI DMIM9N1 DMIM9N1 DN AZD-1080 DMIM9N1 MI TTRSMW9 DMIM9N1 MN Glycogen synthase kinase-3 beta (GSK-3B) DMIM9N1 MT DTT DMIM9N1 MA Modulator DMIM9N1 RN AZD1080, a novel GSK3 inhibitor, rescues synaptic plasticity deficits in rodent brain and exhibits peripheral target engagement in humans.J Neurochem.2013 May;125(3):446-56. DMIM9N1 RU https://www.ncbi.nlm.nih.gov/pubmed/23410232 DM65MUI DI DM65MUI DM65MUI DN AZD1175 DM65MUI MI TT6OEDT DM65MUI MN Cannabinoid receptor 1 (CB1) DM65MUI MT DTT DM65MUI MA Antagonist DM65MUI RN Clinical pipeline report, company report or official report of AstraZeneca (2009). DM65MUI RU http://www.astrazeneca.com/_mshost3690701/content/resources/media/investors/AZN-Q2-2009/AZN-Q2-2009-Pipeline.pdf DMVE4P3 DI DMVE4P3 DMVE4P3 DN AZD1704 DMVE4P3 MI TT6OEDT DMVE4P3 MN Cannabinoid receptor 1 (CB1) DMVE4P3 MT DTT DMVE4P3 MA Antagonist DMVE4P3 RN Clinical pipeline report, company report or official report of AstraZeneca (2009). DMVE4P3 RU http://www.astrazeneca.com/_mshost3690701/content/resources/media/investors/AZN-Q2-2009/AZN-Q2-2009-Pipeline.pdf DMCOMG5 DI DMCOMG5 DMCOMG5 DN AZD-1744 DMCOMG5 MI TTD3XFU DMCOMG5 MN C-C chemokine receptor type 3 (CCR3) DMCOMG5 MT DTT DMCOMG5 MA Modulator DMCOMG5 RN Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41. DMCOMG5 RU https://www.ncbi.nlm.nih.gov/pubmed/15950434 DMCOMG5 DI DMCOMG5 DMCOMG5 DN AZD-1744 DMCOMG5 MI TTTIBOJ DMCOMG5 MN Histamine H1 receptor (H1R) DMCOMG5 MT DTT DMCOMG5 MA Modulator DMCOMG5 RN Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41. DMCOMG5 RU https://www.ncbi.nlm.nih.gov/pubmed/15950434 DMUCQPB DI DMUCQPB DMUCQPB DN AZD-3342 DMUCQPB MI TTZBFA0 DMUCQPB MN Protease unspecific (PRO) DMUCQPB MT DTT DMUCQPB MA Modulator DMUCQPB RN New Drugs and Targets for Asthma and COPD. Trevor T. Hansel, Peter J. Barnes. 2010. Page(227). DMUCQPB RU https://books.google.com.hk/books?id=aHipG471tVgC&pg=PT241&lpg=PT241&dq=%22AZD-3342%22++Protease&source=bl&ots=y_RqGK1AQK&sig=_sZUylCbhLctfTNcybYmrZ3Mbvo&hl=zh-CN&sa=X&ved=0CBoQ6AEwAGoVChMIuJj-gOPAyAIVChmOCh0K3Amt#v=onepage&q=%22AZD-3342%22%20%20Protease&f=false DM7XQTM DI DM7XQTM DM7XQTM DN AZD-4407 DM7XQTM MI TT2J34L DM7XQTM MN Arachidonate 5-lipoxygenase (5-LOX) DM7XQTM MT DTT DM7XQTM MA Inhibitor DM7XQTM RN Palladium catalyzed aryl(alkyl)thiolation of unactivated arenes. Org Lett. 2014 Feb 7;16(3):848-51. DM7XQTM RU https://pubmed.ncbi.nlm.nih.gov/24437617 DMQ2VYT DI DMQ2VYT DMQ2VYT DN AZD-4750 DMQ2VYT MI TTQR8Z6 DMQ2VYT MN Chemokine receptor (CHR) DMQ2VYT MT DTT DMQ2VYT MA Modulator DMQ2VYT RN Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800018778) DMQ2VYT RU http://adisinsight.springer.com/drugs/800018778 DMA3OWI DI DMA3OWI DMA3OWI DN AZD4769 DMA3OWI MI TTDMBF5 DMA3OWI MN Arachidonate 5-lipoxygenase activating protein (FLAP) DMA3OWI MT DTT DMA3OWI MA Inhibitor DMA3OWI RN 5-Lipoxygenase-activating protein is the target of a novel hybrid of two classes of leukotriene biosynthesis inhibitors. Mol Pharmacol. 1992 Feb;41(2):267-72. DMA3OWI RU https://pubmed.ncbi.nlm.nih.gov/1538707 DMA3OWI DI DMA3OWI DMA3OWI DN AZD4769 DMA3OWI MI TTGKNB4 DMA3OWI MN Epidermal growth factor receptor (EGFR) DMA3OWI MT DTT DMA3OWI MA Inhibitor DMA3OWI RN Clinical pipeline report, company report or official report of AstraZeneca (2009). DMA3OWI RU http://www.astrazeneca.com/_mshost3690701/content/resources/media/investors/AZN-Q2-2009/AZN-Q2-2009-Pipeline.pdf DMWKYV7 DI DMWKYV7 DMWKYV7 DN AZD-5099 DMWKYV7 MI TTN6J5F DMWKYV7 MN Bacterial DNA gyrase (Bact gyrase) DMWKYV7 MT DTT DMWKYV7 MA Modulator DMWKYV7 RN Optimization of pyrrolamide topoisomerase II inhibitors toward identification of an antibacterial clinical candidate (AZD5099). J Med Chem. 2014 Jul 24;57(14):6060-82. DMWKYV7 RU https://pubmed.ncbi.nlm.nih.gov/24959892 DM8SCON DI DM8SCON DM8SCON DN AZD5904 DM8SCON MI TTVCZPI DM8SCON MN Myeloperoxidase (MPO) DM8SCON MT DTT DM8SCON MA Inhibitor DM8SCON RN Clinical pipeline report, company report or official report of AstraZeneca (2009). DM8SCON RU http://www.astrazeneca.com/_mshost3690701/content/resources/media/investors/AZN-Q2-2009/AZN-Q2-2009-Pipeline.pdf DMCAKMV DI DMCAKMV DMCAKMV DN AZD5985 DMCAKMV MI TTQDMX5 DMCAKMV MN Prostaglandin D2 receptor 2 (PTGDR2) DMCAKMV MT DTT DMCAKMV MA Antagonist DMCAKMV RN Clinical pipeline report, company report or official report of AstraZeneca (2009). DMCAKMV RU http://www.astrazeneca.com/_mshost3690701/content/resources/media/investors/AZN-Q2-2009/AZN-Q2-2009-Pipeline.pdf DMFAZLU DI DMFAZLU DMFAZLU DN AZD6280 DMFAZLU MI TT37EDJ DMFAZLU MN GABA(A) receptor alpha-3 (GABRA3) DMFAZLU MT DTT DMFAZLU MA Modulator DMFAZLU RN AZD6280, a novel partial -aminobutyric acid A receptor modulator, demonstrates a pharmacodynamically selective effect profile in healthy male volunteers.J Clin Psychopharmacol.2015 Feb;35(1):22-33. DMFAZLU RU https://www.ncbi.nlm.nih.gov/pubmed/25493397 DMQZCET DI DMQZCET DMQZCET DN AZD-6553 DMQZCET MI TTPLTSQ DMQZCET MN Neutrophil elastase (NE) DMQZCET MT DTT DMQZCET MA Inhibitor DMQZCET RN Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800032703) DMQZCET RU http://adisinsight.springer.com/drugs/800032703 DM9KLD3 DI DM9KLD3 DM9KLD3 DN AZD-6703 DM9KLD3 MI TTWELHI DM9KLD3 MN Stress-activated protein kinase (p38) DM9KLD3 MT DTT DM9KLD3 MA Inhibitor DM9KLD3 RN The discovery of N-cyclopropyl-4-methyl-3-[6-(4-methylpiperazin-1-yl)-4-oxoquinazolin-3(4H)-yl]benzamide (AZD6703), a clinical p38alpha MAP kinase inhibitor for the treatment of inflammatory diseases. Bioorg Med Chem Lett. 2012 Jun 15;22(12):3879-83. DM9KLD3 RU https://pubmed.ncbi.nlm.nih.gov/22608965 DMHV3IW DI DMHV3IW DMHV3IW DN AZD-6714 DMHV3IW MI TTDLNGZ DMHV3IW MN Glucokinase (GCK) DMHV3IW MT DTT DMHV3IW MA Stimulator DMHV3IW RN Glucokinase (GCK). SciBX 2(37); doi:10.1038/scibx.2009.1408. Sep. 24 2009 DMHV3IW RU http://www.nature.com/scibx/journal/v2/n37/full/scibx.2009.1408.html DM2QHVW DI DM2QHVW DM2QHVW DN AZD6918 DM2QHVW MI TTTDVOJ DM2QHVW MN Tropomyosin-related kinase A (TrkA) DM2QHVW MT DTT DM2QHVW MA Inhibitor DM2QHVW RN Clinical pipeline report, company report or official report of AstraZeneca (2009). DM2QHVW RU http://www.astrazeneca.com/_mshost3690701/content/resources/media/investors/AZN-Q2-2009/AZN-Q2-2009-Pipeline.pdf DMX63W1 DI DMX63W1 DMX63W1 DN AZD-7140 DMX63W1 MI TTQR8Z6 DMX63W1 MN Chemokine receptor (CHR) DMX63W1 MT DTT DMX63W1 MA Antagonist DMX63W1 RN Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800017126) DMX63W1 RU http://adisinsight.springer.com/drugs/800017126 DMKF9U3 DI DMKF9U3 DMKF9U3 DN AZD8075 DMKF9U3 MI TTQDMX5 DMKF9U3 MN Prostaglandin D2 receptor 2 (PTGDR2) DMKF9U3 MT DTT DMKF9U3 MA Antagonist DMKF9U3 RN Clinical pipeline report, company report or official report of AstraZeneca (2009). DMKF9U3 RU http://www.astrazeneca.com/_mshost3690701/content/resources/media/investors/AZN-Q2-2009/AZN-Q2-2009-Pipeline.pdf DMW6IUB DI DMW6IUB DMW6IUB DN AZD-8309 DMW6IUB MI TTQR8Z6 DMW6IUB MN Chemokine receptor (CHR) DMW6IUB MT DTT DMW6IUB MA Modulator DMW6IUB RN CXCR2: From Bench to Bedside. Front Immunol. 2012; 3: 263. DMW6IUB RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3426767/ DMUKNQ5 DI DMUKNQ5 DMUKNQ5 DN AZD8330 DMUKNQ5 MI TTROQ37 DMUKNQ5 MN MAPK/ERK kinase kinase (MAP3K) DMUKNQ5 MT DTT DMUKNQ5 MA Modulator DMUKNQ5 RN MEK and the inhibitors: from bench to bedside. J Hematol Oncol. 2013; 6: 27. DMUKNQ5 RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3626705/ DMIYEZG DI DMIYEZG DMIYEZG DN AZD8566 DMIYEZG MI TT2CEJG DMIYEZG MN C-C chemokine receptor type 5 (CCR5) DMIYEZG MT DTT DMIYEZG MA Antagonist DMIYEZG RN Clinical pipeline report, company report or official report of AstraZeneca (2009). DMIYEZG RU http://www.astrazeneca.com/_mshost3690701/content/resources/media/investors/AZN-Q2-2009/AZN-Q2-2009-Pipeline.pdf DMYSBN3 DI DMYSBN3 DMYSBN3 DN AZD-9272 DMYSBN3 MI TTVBPDM DMYSBN3 MN Metabotropic glutamate receptor 1 (mGluR1) DMYSBN3 MT DTT DMYSBN3 MA Modulator DMYSBN3 RN Emerging drugs in neuropathic pain. Expert Opin Emerg Drugs. 2007 Mar;12(1):113-26. DMYSBN3 RU https://pubmed.ncbi.nlm.nih.gov/17355217 DM1ZVO3 DI DM1ZVO3 DM1ZVO3 DN AZD-9343 DM1ZVO3 MI TTDCVZW DM1ZVO3 MN Gamma-aminobutyric acid B receptor (GABBR) DM1ZVO3 MT DTT DM1ZVO3 MA Modulator DM1ZVO3 RN The GABA(B) receptor agonist AZD9343 inhibits transient lower oesophageal sphincter relaxations and acid reflux in healthy volunteers: a phase I study. Aliment Pharmacol Ther. 2009 Nov 1;30(9):937-46. DM1ZVO3 RU https://pubmed.ncbi.nlm.nih.gov/19650825 DMK5I07 DI DMK5I07 DMK5I07 DN Banoxantrone DMK5I07 MI DEPKLMQ DMK5I07 MN Cytochrome P450 2B6 (CYP2B6) DMK5I07 MT DME DMK5I07 MA Metabolism DMK5I07 RN Tumor-selective drug activation: a GDEPT approach utilizing cytochrome P450 1A1 and AQ4N. Cancer Gene Ther. 2006 Jun;13(6):598-605. DMK5I07 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=16410820 DMK5I07 DI DMK5I07 DMK5I07 DN Banoxantrone DMK5I07 MI DE4LYSA DMK5I07 MN Cytochrome P450 3A4 (CYP3A4) DMK5I07 MT DME DMK5I07 MA Metabolism DMK5I07 RN Bioreductive GDEPT using cytochrome P450 3A4 in combination with AQ4N. Cancer Gene Ther. 2003 Jan;10(1):40-8. DMK5I07 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=12489027 DMK5I07 DI DMK5I07 DMK5I07 DN Banoxantrone DMK5I07 MI TT0IHXV DMK5I07 MN DNA topoisomerase II (TOP2) DMK5I07 MT DTT DMK5I07 MA Modulator DMK5I07 RN Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41. DMK5I07 RU https://www.ncbi.nlm.nih.gov/pubmed/15950434 DMGDSCK DI DMGDSCK DMGDSCK DN BAY-27-9955 DMGDSCK MI TT9O6WS DMGDSCK MN Glucagon receptor (GCGR) DMGDSCK MT DTT DMGDSCK MA Antagonist DMGDSCK RN Effects of a novel glucagon receptor antagonist (Bay 27-9955) on glucagon-stimulated glucose production in humans. Diabetologia. 2001 Nov;44(11):2018-24. DMGDSCK RU https://pubmed.ncbi.nlm.nih.gov/11719833 DMKJ3IA DI DMKJ3IA DMKJ3IA DN BAY-73-7977 DMKJ3IA MI TT9O6WS DMKJ3IA MN Glucagon receptor (GCGR) DMKJ3IA MT DTT DMKJ3IA MA Antagonist DMKJ3IA RN WO patent application no. 2012,0351,39, Prodrugs comprising an exendin linker conjugate. DMKJ3IA RU http://worldwide.espacenet.com/publicationDetails/biblio?DB=worldwide.espacenet.com&II=0&ND=3&adjacent=true&locale=en_EP&FT=D&date=20120322&CC=WO&NR=2012035139A1&KC=A1 DM0UEKF DI DM0UEKF DM0UEKF DN BAY-Y-1015 DM0UEKF MI TTTWGIX DM0UEKF MN Leukotriene receptor (LTR) DM0UEKF MT DTT DM0UEKF MA Modulator DM0UEKF RN The effect of leukotriene synthesis inhibitors in models of acute and chronic inflammation. Arthritis Rheum. 1996 Mar;39(3):515-21. DM0UEKF RU https://pubmed.ncbi.nlm.nih.gov/8607901 DMYK8OG DI DMYK8OG DMYK8OG DN BB-2983 DMYK8OG MI TT1GHVO DMYK8OG MN Matrix metalloproteinase (MMP) DMYK8OG MT DTT DMYK8OG MA Modulator DMYK8OG RN Matrix metalloproteinase inhibition reduces intimal hyperplasia in a porcine arteriovenous-graft model. J Vasc Surg. 2004 Feb;39(2):432-9. DMYK8OG RU https://pubmed.ncbi.nlm.nih.gov/14743149 DMN2XR7 DI DMN2XR7 DMN2XR7 DN BCX-1470 DMN2XR7 MI TT6L509 DMN2XR7 MN Coagulation factor IIa (F2) DMN2XR7 MT DTT DMN2XR7 MA Inhibitor DMN2XR7 RN Recent Developments in Low Molecular Weight Complement Inhibitors. Mol Immunol. 2009 December; 47(2-3): 185-195. DMN2XR7 RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2788007/ DMCOKFY DI DMCOKFY DMCOKFY DN Beloxepin DMCOKFY MI TTYSN63 DMCOKFY MN 5-HT 2 receptor (5HT2R) DMCOKFY MT DTT DMCOKFY MA Modulator DMCOKFY RN WO patent application no. 2009,1055,07, Beloxepin, its enantiomers, and analogs thereof for the treatment of pain. DMCOKFY RU http://worldwide.espacenet.com/publicationDetails/biblio?DB=worldwide.espacenet.com&II=0&ND=3&adjacent=true&locale=en_EP&FT=D&date=20090827&CC=WO&NR=2009105507A2&KC=A2 DMQI2F4 DI DMQI2F4 DMQI2F4 DN BEPH DMQI2F4 MI TT0DBAO DMQI2F4 MN Polyamine unspecific (PLA) DMQI2F4 MT DTT DMQI2F4 MA Modulator DMQI2F4 RN Antitumor activity of a novel synthetic polyamine analogue, N,N'-bis-[3-(ethylamino)-propyl]-1-7-heptane diamine: potentiation by polyamine oxidase inhibitors. Anticancer Res. 1990 Sep-Oct;10(5A):1281-7. DMQI2F4 RU https://pubmed.ncbi.nlm.nih.gov/2241104 DMU1YON DI DMU1YON DMU1YON DN Berupipam DMU1YON MI TTZFYLI DMU1YON MN Dopamine D1 receptor (D1R) DMU1YON MT DTT DMU1YON MA Antagonist DMU1YON RN Characterization of benzazepine UDP-glucuronosyl-transferases in laboratory animals and man. Xenobiotica. 1995 Jun;25(6):611-22. DMU1YON RU https://pubmed.ncbi.nlm.nih.gov/7483661 DMMAFQP DI DMMAFQP DMMAFQP DN Besonprodil DMMAFQP MI TTN9D8E DMMAFQP MN Glutamate receptor ionotropic NMDA 2B (NMDAR2B) DMMAFQP MT DTT DMMAFQP MA Antagonist DMMAFQP RN Glutamate- and GABA-based CNS therapeutics. Curr Opin Pharmacol. 2006 Feb;6(1):7-17. DMMAFQP RU https://pubmed.ncbi.nlm.nih.gov/16377242 DM9F4LP DI DM9F4LP DM9F4LP DN BIM-26226 DM9F4LP MI TTC1MVT DM9F4LP MN Gastrin-releasing peptide receptor (GRPR) DM9F4LP MT DTT DM9F4LP MA Modulator DM9F4LP RN Effect of the gastrin-releasing peptide antagonist BIM 26226 and lanreotide on an acinar pancreatic carcinoma. Eur J Pharmacol. 1998 Apr 17;347(1):77-86. DM9F4LP RU https://pubmed.ncbi.nlm.nih.gov/9650851 DM3HRQI DI DM3HRQI DM3HRQI DN BINOSPIRONE MESYLATE DM3HRQI MI TTSQIFT DM3HRQI MN 5-HT 1A receptor (HTR1A) DM3HRQI MT DTT DM3HRQI MA Antagonist DM3HRQI RN Quantifying the 5-HT1A agonist action of buspirone in man. Psychopharmacology (Berl). 2001 Nov;158(3):224-9. DM3HRQI RU https://pubmed.ncbi.nlm.nih.gov/11713611 DMJWLBU DI DMJWLBU DMJWLBU DN BL-1827 DMJWLBU MI TTN4QDT DMJWLBU MN Opioid receptor (OPR) DMJWLBU MT DTT DMJWLBU MA Agonist DMJWLBU RN Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800013581) DMJWLBU RU http://adisinsight.springer.com/drugs/800013581 DMR7WYX DI DMR7WYX DMR7WYX DN BLX-883 DMR7WYX MI TTSYFMA DMR7WYX MN Interferon alpha/beta receptor 1 (IFNAR1) DMR7WYX MT DTT DMR7WYX MA Modulator DMR7WYX RN Patent CN103536906 A. DMR7WYX RU http://www.google.com/patents/CN103536906A?cl=en DMKFXTD DI DMKFXTD DMKFXTD DN BMS-191095 DMKFXTD MI TTEF5MJ DMKFXTD MN ATP-binding cassette transporter C9 (ABCC9) DMKFXTD MT DTT DMKFXTD MA Modulator DMKFXTD RN The mitochondrial K(ATP) channel opener BMS-191095 reduces neuronal damage after transient focal cerebral ischemia in rats.J Cereb Blood Flow Metab.2007 Feb;27(2):348-55. DMKFXTD RU https://www.ncbi.nlm.nih.gov/pubmed/16736040 DMIX9O0 DI DMIX9O0 DMIX9O0 DN BRL-44154 DMIX9O0 MI TTJP4SM DMIX9O0 MN Bacterial Penicillin binding protein (Bact PBP) DMIX9O0 MT DTT DMIX9O0 MA Modulator DMIX9O0 RN Can beta-lactams be re-engineered to beat MRSA . Clinical Microbiology and Infection Volume 12, Issue Supplement s2, pages 11-16, April 2006. DMIX9O0 RU http://onlinelibrary.wiley.com/doi/10.1111/j.1469-0691.2006.01403.x/full DMGVEJ6 DI DMGVEJ6 DMGVEJ6 DN BTS-73947 DMGVEJ6 MI TTZFYLI DMGVEJ6 MN Dopamine D1 receptor (D1R) DMGVEJ6 MT DTT DMGVEJ6 MA Antagonist DMGVEJ6 RN Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800008043) DMGVEJ6 RU http://adisinsight.springer.com/drugs/800008043 DM296HE DI DM296HE DM296HE DN BW-1370U87 DM296HE MI TT3WG5C DM296HE MN Monoamine oxidase type A (MAO-A) DM296HE MT DTT DM296HE MA Inhibitor DM296HE RN Preclinical and early clinical studies with BW 1370U87, a reversible competitive monoamine oxidase-A inhibitor. Clin Neuropharmacol. 1993;16 Suppl 2:S25-33. DM296HE RU https://pubmed.ncbi.nlm.nih.gov/8313394 DMUD6IK DI DMUD6IK DMUD6IK DN BXL-746 DMUD6IK MI TTK59TV DMUD6IK MN Vitamin D3 receptor (VDR) DMUD6IK MT DTT DMUD6IK MA Stimulator DMUD6IK RN Inter-species differences in sensitivity to the calcemic activity of the novel 1,25-dihydroxyvitamin D3 analog BXL746. Regul Toxicol Pharmacol. 2008 Dec;52(3):332-41. DMUD6IK RU https://pubmed.ncbi.nlm.nih.gov/18854204 DMSTN6W DI DMSTN6W DMSTN6W DN CA9-ADC DMSTN6W MI TT2LVK8 DMSTN6W MN Carbonic anhydrase IX (CA-IX) DMSTN6W MT DTT DMSTN6W RN Therapeutic mechanism and efficacy of the antibody-drug conjugate BAY 79-4620 targeting human carbonic anhydrase 9. Mol Cancer Ther. 2012 Feb;11(2):340-9. DMSTN6W RU https://pubmed.ncbi.nlm.nih.gov/22147747 DMQ4HUA DI DMQ4HUA DMQ4HUA DN CAB-2 DMQ4HUA MI TTA0P7K DMQ4HUA MN Complement factor B (CFB) DMQ4HUA MT DTT DMQ4HUA MA Inhibitor DMQ4HUA RN A soluble chimeric inhibitor of C3 and C5 convertases, complement activation blocker-2, prolongs graft survival in pig-to-rhesus monkey heart transplantation. Xenotransplantation. 2002 Mar;9(2):125-34. DMQ4HUA RU https://pubmed.ncbi.nlm.nih.gov/11897005 DMQIWZL DI DMQIWZL DMQIWZL DN Candoxatrilat DMQIWZL MI TT5TKPM DMQIWZL MN Neutral endopeptidase (MME) DMQIWZL MT DTT DMQIWZL MA Inhibitor DMQIWZL RN Candoxatril, an orally active neutral endopeptidase inhibitor, raises plasma atrial natriuretic factor and is natriuretic in essential hypertension. J Hypertens. 1992 Mar;10(3):271-7. DMQIWZL RU https://pubmed.ncbi.nlm.nih.gov/1315825 DMYCPF9 DI DMYCPF9 DMYCPF9 DN CB-182804 DMYCPF9 MI TTXT4D5 DMYCPF9 MN Bacterial Cell membrane (Bact CM) DMYCPF9 MT DTT DMYCPF9 MA Inhibitor DMYCPF9 RN Activity of polymyxin B and the novel polymyxin analogue CB-182,804 against contemporary Gram-negative pathogens in New York City. Microb Drug Resist. 2012 Apr;18(2):132-6. DMYCPF9 RU https://pubmed.ncbi.nlm.nih.gov/22196342 DM3G4JD DI DM3G4JD DM3G4JD DN CBD cannabis derivative DM3G4JD MI TT6OEDT DM3G4JD MN Cannabinoid receptor 1 (CB1) DM3G4JD MT DTT DM3G4JD MA Antagonist DM3G4JD RN The pipeline and future of drug development in schizophrenia. Mol Psychiatry. 2007 Oct;12(10):904-22. DM3G4JD RU https://pubmed.ncbi.nlm.nih.gov/17667958 DMMEC1W DI DMMEC1W DMMEC1W DN CCD-3693 DMMEC1W MI TTEX6LM DMMEC1W MN GABA(A) receptor gamma-3 (GABRG3) DMMEC1W MT DTT DMMEC1W MA Modulator DMMEC1W RN Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41. DMMEC1W RU https://www.ncbi.nlm.nih.gov/pubmed/15950434 DMD8QHV DI DMD8QHV DMD8QHV DN CCX-832 DMD8QHV MI TTE836A DMD8QHV MN C-C chemokine receptor type 8 (CCR8) DMD8QHV MT DTT DMD8QHV MA Antagonist DMD8QHV RN Increased Expression of Chemerin in Squamous Esophageal Cancer Myofibroblasts and Role in Recruitment of Mesenchymal Stromal Cells. PLoS One. 2014; 9(8): e104877. DMD8QHV RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4134237/ DMHMST3 DI DMHMST3 DMHMST3 DN CCX915 DMHMST3 MI TTEF5MJ DMHMST3 MN ATP-binding cassette transporter C9 (ABCC9) DMHMST3 MT DTT DMHMST3 MA Blocker DMHMST3 RN Analysis of the differential modulation of sulphonylurea block of beta-cell and cardiac ATP-sensitive K+ (K(ATP)) channels by Mg-nucleotides. J Physiol. 2003 Feb 15;547(Pt 1):159-68. DMHMST3 RU https://pubmed.ncbi.nlm.nih.gov/12562963 DMHMST3 DI DMHMST3 DMHMST3 DN CCX915 DMHMST3 MI TTFZYTO DMHMST3 MN C-C chemokine receptor type 2 (CCR2) DMHMST3 MT DTT DMHMST3 MA Antagonist DMHMST3 RN Marketed and experimental medicines for the treatment of multiple sclerosis. The Association of the British Pharmaceutical Industry. 2009. DMHMST3 RU http://www.abpi.org.uk/publications/publication_details/targetMS/table.asp DMOCBQW DI DMOCBQW DMOCBQW DN CD-581 DMOCBQW MI TT2J34L DMOCBQW MN Arachidonate 5-lipoxygenase (5-LOX) DMOCBQW MT DTT DMOCBQW MA Inhibitor DMOCBQW RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015 DMOCBQW RU https://www.accessdata.fda.gov/scripts/cder/drugsatfda/ DM5BG4P DI DM5BG4P DM5BG4P DN CDP-1050 DM5BG4P MI TTU5CIX DM5BG4P MN Ryanodine receptor 1 (RYR1) DM5BG4P MT DTT DM5BG4P MA Modulator DM5BG4P RN The Ryanodine Receptor Stabilizer S44121 / Arm036 Improves Peripheral and Respiratory Muscle Function in a Mouse Model of Heart Failure. Circulation. 2014; 130: A13726. DM5BG4P RU http://circ.ahajournals.org/content/130/Suppl_2/A13726.abstract DMJVZ9O DI DMJVZ9O DMJVZ9O DN Cefdaloxime pentexil tosilate DMJVZ9O MI TTJP4SM DMJVZ9O MN Bacterial Penicillin binding protein (Bact PBP) DMJVZ9O MT DTT DMJVZ9O MA Modulator DMJVZ9O RN Activity of cefpodoxime and other oral beta-lactams against Haemophilus influenzae and Streptococcus pneumoniae with different susceptibilities to penicillin. Rev Esp Quimioter. 2006 Mar;19(1):39-44. DMJVZ9O RU https://pubmed.ncbi.nlm.nih.gov/16688290 DMO075K DI DMO075K DMO075K DN CEFTRAZONAL BOPENTIL DMO075K MI TTJP4SM DMO075K MN Bacterial Penicillin binding protein (Bact PBP) DMO075K MT DTT DMO075K MA Inhibitor DMO075K RN Comparative in vitro activity of Ro 40-6890, Ro 41-3399, and other antimicrobial agents against anaerobic bacteria. Eur J Clin Microbiol Infect Dis. 1992 Oct;11(10):946-9. DMO075K RU https://pubmed.ncbi.nlm.nih.gov/1486894 DMH1PQ0 DI DMH1PQ0 DMH1PQ0 DN CEP-2563 DMH1PQ0 MI TTXABCW DMH1PQ0 MN NT-3 growth factor receptor (TrkC) DMH1PQ0 MT DTT DMH1PQ0 MA Modulator DMH1PQ0 RN Phase I clinical trial of CEP-2563 dihydrochloride, a receptor tyrosine kinase inhibitor, in patients with refractory solid tumors. Invest New Drugs. 2004 Nov;22(4):449-58. DMH1PQ0 RU https://pubmed.ncbi.nlm.nih.gov/15292715 DMH1PQ0 DI DMH1PQ0 DMH1PQ0 DN CEP-2563 DMH1PQ0 MI TT8FYO9 DMH1PQ0 MN Platelet-derived growth factor receptor alpha (PDGFRA) DMH1PQ0 MT DTT DMH1PQ0 MA Inhibitor DMH1PQ0 RN Phase I clinical trial of CEP-2563 dihydrochloride, a receptor tyrosine kinase inhibitor, in patients with refractory solid tumors. Invest New Drugs. 2004 Nov;22(4):449-58. DMH1PQ0 RU https://pubmed.ncbi.nlm.nih.gov/15292715 DMH1PQ0 DI DMH1PQ0 DMH1PQ0 DN CEP-2563 DMH1PQ0 MI TTI7421 DMH1PQ0 MN Platelet-derived growth factor receptor beta (PDGFRB) DMH1PQ0 MT DTT DMH1PQ0 MA Inhibitor DMH1PQ0 RN Therapeutic target database update 2012: a resource for facilitating target-oriented drug discovery. Nucleic Acids Res. 2012 Jan;40(Database issue):D1128-36. DMH1PQ0 RU https://pubmed.ncbi.nlm.nih.gov/21948793 DMK93VQ DI DMK93VQ DMK93VQ DN CEREBROCRAST DMK93VQ MI TT5HONZ DMK93VQ MN Calcium channel unspecific (CaC) DMK93VQ MT DTT DMK93VQ MA Inhibitor DMK93VQ RN The dihydropyridine analogue cerebrocrast blocks both T-type and L-type calcium currents. Can J Physiol Pharmacol. 2009 Nov;87(11):923-32. DMK93VQ RU https://pubmed.ncbi.nlm.nih.gov/19935900 DMQKRWO DI DMQKRWO DMQKRWO DN CERM-11956 DMQKRWO MI TT5HONZ DMQKRWO MN Calcium channel unspecific (CaC) DMQKRWO MT DTT DMQKRWO MA Antagonist DMQKRWO RN The anti-ischaemic activity of the novel compound, CERM 11956, compared with that of bepridil and nifedipine in isolated guinea-pig hearts. Eur J Pharmacol. 1988 May 10;149(3):195-203. DMQKRWO RU https://pubmed.ncbi.nlm.nih.gov/3261692 DM85SYL DI DM85SYL DM85SYL DN Cetefloxacin DM85SYL MI TTN6J5F DM85SYL MN Bacterial DNA gyrase (Bact gyrase) DM85SYL MT DTT DM85SYL MA Modulator DM85SYL RN Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41. DM85SYL RU https://www.ncbi.nlm.nih.gov/pubmed/15950434 DMOULQ4 DI DMOULQ4 DMOULQ4 DN CGP-37849 DMOULQ4 MI TT9IK2Z DMOULQ4 MN N-methyl-D-aspartate receptor (NMDAR) DMOULQ4 MT DTT DMOULQ4 MA Modulator DMOULQ4 RN The competitive NMDA receptor antagonists CGP 37849 and CGP 39551 are potent, orally-active anticonvulsants in rodents. Naunyn Schmiedebergs Arch Pharmacol. 1990 Jul;342(1):61-6. DMOULQ4 RU https://pubmed.ncbi.nlm.nih.gov/1976233 DMY8KO4 DI DMY8KO4 DMY8KO4 DN CGP-48369 DMY8KO4 MI TTGN1ZA DMY8KO4 MN Angiotensin II receptor (AGTR) DMY8KO4 MT DTT DMY8KO4 MA Modulator DMY8KO4 RN Antihypertensive therapy augments endothelium-dependent relaxations in coronary arteries of spontaneously hypertensive rats. Circulation. 1994 May;89(5):2212-8. DMY8KO4 RU https://pubmed.ncbi.nlm.nih.gov/8181147 DMF0O2H DI DMF0O2H DMF0O2H DN CGP-53437 DMF0O2H MI TT5FNQT DMF0O2H MN Human immunodeficiency virus Protease (HIV PR) DMF0O2H MT DTT DMF0O2H MA Inhibitor DMF0O2H RN CGP 53437, an orally bioavailable inhibitor of human immunodeficiency virus type 1 protease with potent antiviral activity. Antimicrob Agents Chemother. 1993 Oct;37(10):2087-92. DMF0O2H RU https://pubmed.ncbi.nlm.nih.gov/8257128 DMF05DL DI DMF05DL DMF05DL DN CGS-22652 DMF05DL MI TT2O84V DMF05DL MN Thromboxane A2 receptor (TBXA2R) DMF05DL MT DTT DMF05DL MA Modulator DMF05DL RN Blood pressure effects of thromboxane A2 blockade in spontaneously hypertensive rats. Clin Exp Pharmacol Physiol. 1993 Nov;20(11):679-87. DMF05DL RU https://www.ncbi.nlm.nih.gov/pubmed/8306513 DM0JUAL DI DM0JUAL DM0JUAL DN ChelASE DM0JUAL MI TTLG1PD DM0JUAL MN Proliferating cell nuclear antigen (PCNA) DM0JUAL MT DTT DM0JUAL MA Inhibitor DM0JUAL RN Safety and efficacy assessment of chimeric ribozyme to proliferating cell nuclear antigen to prevent recurrence of proliferative vitreoretinopathy. Arch Ophthalmol. 2007 Sep;125(9):1161-7. DM0JUAL RU https://pubmed.ncbi.nlm.nih.gov/17846353 DMJ5UYL DI DMJ5UYL DMJ5UYL DN Chpmpc DMJ5UYL MI TTIU7X1 DMJ5UYL MN Herpes simplex virus DNA polymerase UL30 (HSV UL30) DMJ5UYL MT DTT DMJ5UYL MA Modulator DMJ5UYL RN Conversion of 1-[((S)-2-hydroxy-2-oxo-1,4,2-dioxaphosphorinan-5-yl)methyl]cytosine to cidofovir by an intracellular cyclic CMP phosphodiesterase.. Antimicrob Agents Chemother. 1997 March; 41(3): 641-646. DMJ5UYL RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC163765/ DM9ZBO0 DI DM9ZBO0 DM9ZBO0 DN CI-972 DM9ZBO0 MI TTMCF1Y DM9ZBO0 MN Purine nucleoside phosphorylase (PNP) DM9ZBO0 MT DTT DM9ZBO0 MA Inhibitor DM9ZBO0 RN Inhibitors of human purine nucleoside phosphorylase. Synthesis of pyrrolo[3,2-d]pyrimidines, a new class of purine nucleoside phosphorylase inhibitors as potentially T-cell selective immunosuppressive agents. Description of 2,6-diamino-3,5-dihydro-7-(3-thienylmethyl)-4H-pyrrolo[3,2-d] pyrimidin-4-one. J Med Chem. 1992 May 1;35(9):1605-9. DM9ZBO0 RU https://pubmed.ncbi.nlm.nih.gov/1578487 DM3Q8UW DI DM3Q8UW DM3Q8UW DN CJC-1004 DM3Q8UW MI TT6L509 DM3Q8UW MN Coagulation factor IIa (F2) DM3Q8UW MT DTT DM3Q8UW MA Inhibitor DM3Q8UW RN Gateways to clinical trials. Methods Find Exp Clin Pharmacol. 2003 Jun;25(5):387-408. DM3Q8UW RU https://pubmed.ncbi.nlm.nih.gov/12851663 DMSB7WV DI DMSB7WV DMSB7WV DN CL-277082 DMSB7WV MI TTMF541 DMSB7WV MN Liver carboxylesterase (CES1) DMSB7WV MT DTT DMSB7WV MA Modulator DMSB7WV RN CL 277,082: a novel inhibitor of ACAT-catalyzed cholesterol esterification and cholesterol absorption. J Lipid Res. 1989 May;30(5):681-90. DMSB7WV RU https://pubmed.ncbi.nlm.nih.gov/2760542 DMYPFLR DI DMYPFLR DMYPFLR DN Clomet DMYPFLR MI TTUTN1I DMYPFLR MN Human Deoxyribonucleic acid (hDNA) DMYPFLR MT DTT DMYPFLR MA Inhibitor DMYPFLR RN The comet assay: a sensitive genotoxicity test for the detection of DNA damage and repair. Methods Mol Biol. 2006;314:275-86. DMYPFLR RU https://pubmed.ncbi.nlm.nih.gov/16673888 DM1C4IN DI DM1C4IN DM1C4IN DN CP-105696 DM1C4IN MI TTN53ZF DM1C4IN MN Leukotriene B4 receptor 1 (LTB4R) DM1C4IN MT DTT DM1C4IN MA Inhibitor DM1C4IN RN 3-Substituted-4-hydroxy-7-chromanylacetic acid derivatives as antagonists of the leukotriene B4 (LTB4) receptor, Bioorg. Med. Chem. 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Product Development Pipeline. March 31 2009. DMZ0YU7 RU http://media.pfizer.com/files/research/pipeline/2009_0331/pipeline_2009_0331.pdf DMWVBGD DI DMWVBGD DMWVBGD DN CR-2093 DMWVBGD MI TTVFO0U DMWVBGD MN Gastrin/cholecystokinin type B receptor (CCKBR) DMWVBGD MT DTT DMWVBGD MA Modulator DMWVBGD RN Inhibitory effects of the gastrin receptor antagonist CR2093 on basal, gastrin-stimulated and growth factor-stimulated growth of the rat pancreatic cell line AR42J. Anticancer Drugs. 1994 Oct;5(5):591-7. DMWVBGD RU https://pubmed.ncbi.nlm.nih.gov/7858292 DMVDLT4 DI DMVDLT4 DMVDLT4 DN CS-4771 DMVDLT4 MI TTISGCA DMVDLT4 MN Toll-like receptor 4 (TLR4) DMVDLT4 MT DTT DMVDLT4 MA Modulator DMVDLT4 RN Eritoran insight for influenza treatment. SciBX 6(19); doi:10.1038/scibx.2013.453. May 16 2013 DMVDLT4 RU http://www.nature.com/scibx/journal/v6/n19/full/scibx.2013.453.html DMXKB8V DI DMXKB8V DMXKB8V DN CS-526 DMXKB8V MI TTLOKXP DMXKB8V MN Gastric H(+)/K(+) ATPase (Proton pump) DMXKB8V MT DTT DMXKB8V MA Modulator DMXKB8V RN Pharmacological profile of novel acid pump antagonist 7-(4-fluorobenzyloxy)-2,3-dimethyl-1-{[(1S,2S)-2-methyl cyclopropyl]methyl}-1H-pyrrolo[2,3-d]... J Pharmacol Exp Ther. 2007 Oct;323(1):308-17. DMXKB8V RU https://pubmed.ncbi.nlm.nih.gov/17630360 DMXY43L DI DMXY43L DMXY43L DN CTP-354 DMXY43L MI TTEX6LM DMXY43L MN GABA(A) receptor gamma-3 (GABRG3) DMXY43L MT DTT DMXY43L MA Modulator DMXY43L RN Clinical pipeline report, company report or official report of Concert Pharmaceuticals. DMXY43L RU http://www.concertpharma.com/news/documents/CTP-354_ACNP_Liu_final.pdf DMDRFZV DI DMDRFZV DMDRFZV DN CVS-1123 DMDRFZV MI TT6L509 DMDRFZV MN Coagulation factor IIa (F2) DMDRFZV MT DTT DMDRFZV MA Inhibitor DMDRFZV RN CVS-1123, a direct thrombin inhibitor, prevents occlusive arterial and venous thrombosis in a canine model of vascular injury. J Cardiovasc Pharmacol. 1997 Feb;29(2):240-9. DMDRFZV RU https://pubmed.ncbi.nlm.nih.gov/9057074 DMWY2NT DI DMWY2NT DMWY2NT DN CY-1787 DMWY2NT MI TTE5VG0 DMWY2NT MN P-selectin (SELP) DMWY2NT MT DTT DMWY2NT MA Modulator DMWY2NT RN Administration of an antibody to E-selectin in patients with septic shock. Crit Care Med. 1996 Feb;24(2):229-33. DMWY2NT RU https://pubmed.ncbi.nlm.nih.gov/8605793 DM1I7UO DI DM1I7UO DM1I7UO DN Cyclocreatine DM1I7UO MI TTU8W4S DM1I7UO MN Protein kinase (PK) DM1I7UO MT DTT DM1I7UO MA Inhibitor DM1I7UO RN Direct determination of creatine kinase equilibrium constants with creatine or cyclocreatine substrate. Biochim Biophys Acta. 1989 Oct 19;998(3):317-20. DM1I7UO RU https://pubmed.ncbi.nlm.nih.gov/2804134 DMB24V7 DI DMB24V7 DMB24V7 DN D-1367 DMB24V7 MI TTK0943 DMB24V7 MN Prostaglandin G/H synthase (COX) DMB24V7 MT DTT DMB24V7 MA Modulator DMB24V7 RN US patent application no. 2007,0072,861, Method of using cyclooxygenase-2 inhibitors in the prevention of cardiovascular disorders. DMB24V7 RU http://www.google.com.ar/patents/US20070072861 DM5D8JW DI DM5D8JW DM5D8JW DN D-1927 DM5D8JW MI TT1GHVO DM5D8JW MN Matrix metalloproteinase (MMP) DM5D8JW MT DTT DM5D8JW MA Modulator DM5D8JW RN Correlation of antiangiogenic and antitumor efficacy of N-biphenyl sulfonyl-phenylalanine hydroxiamic acid (BPHA), an orally-active, selective matrix metalloproteinase inhibitor. Cancer Res. 1999 Mar15;59(6):1231-5. DM5D8JW RU https://pubmed.ncbi.nlm.nih.gov/10096553 DMUPEJK DI DMUPEJK DMUPEJK DN D-4418 DMUPEJK MI TTZ97H5 DMUPEJK MN Phosphodiesterase 4A (PDE4A) DMUPEJK MT DTT DMUPEJK MA Inhibitor DMUPEJK RN Can the anti-inflammatory potential of PDE4 inhibitors be realized: guarded optimism or wishful thinking. Br J Pharmacol. 2008 Oct;155(3):288-90. DMUPEJK RU https://pubmed.ncbi.nlm.nih.gov/18660832 DMUPEJK DI DMUPEJK DMUPEJK DN D-4418 DMUPEJK MI TTVIAT9 DMUPEJK MN Phosphodiesterase 4B (PDE4B) DMUPEJK MT DTT DMUPEJK MA Inhibitor DMUPEJK RN Can the anti-inflammatory potential of PDE4 inhibitors be realized: guarded optimism or wishful thinking. Br J Pharmacol. 2008 Oct;155(3):288-90. DMUPEJK RU https://pubmed.ncbi.nlm.nih.gov/18660832 DMUPEJK DI DMUPEJK DMUPEJK DN D-4418 DMUPEJK MI TTSKMI8 DMUPEJK MN Phosphodiesterase 4D (PDE4D) DMUPEJK MT DTT DMUPEJK MA Inhibitor DMUPEJK RN Can the anti-inflammatory potential of PDE4 inhibitors be realized: guarded optimism or wishful thinking. Br J Pharmacol. 2008 Oct;155(3):288-90. DMUPEJK RU https://pubmed.ncbi.nlm.nih.gov/18660832 DMDUZ5W DI DMDUZ5W DMDUZ5W DN DACOPAFANT DMDUZ5W MI TTQL5VC DMDUZ5W MN Platelet-activating factor receptor (PTAFR) DMDUZ5W MT DTT DMDUZ5W MA Antagonist DMDUZ5W RN RP 55778, a PAF receptor antagonist, prevents and reverses LPS-induced hemoconcentration and TNF release. J Lipid Mediat. 1989 Nov-Dec;1(6):349-60. DMDUZ5W RU https://pubmed.ncbi.nlm.nih.gov/2519903 DMAOZH3 DI DMAOZH3 DMAOZH3 DN DE-310 DMAOZH3 MI TTGTQHC DMAOZH3 MN DNA topoisomerase I (TOP1) DMAOZH3 MT DTT DMAOZH3 MA Inhibitor DMAOZH3 RN DE-310, a macromolecular prodrug of the topoisomerase-I-inhibitor exatecan (DX-8951), in patients with operable solid tumors. Invest New Drugs. 2005 Aug;23(4):339-47. DMAOZH3 RU https://pubmed.ncbi.nlm.nih.gov/16012793 DMFUCZQ DI DMFUCZQ DMFUCZQ DN Delucemine DMFUCZQ MI TT9IK2Z DMFUCZQ MN N-methyl-D-aspartate receptor (NMDAR) DMFUCZQ MT DTT DMFUCZQ MA Modulator DMFUCZQ RN NPS 1506, a novel NMDA receptor antagonist and neuroprotectant. Review of preclinical and clinical studies. Ann N Y Acad Sci. 1999;890:450-7. DMFUCZQ RU https://pubmed.ncbi.nlm.nih.gov/10668449 DM5G43H DI DM5G43H DM5G43H DN Denibulin DM5G43H MI TTYFKSZ DM5G43H MN Tubulin beta (TUBB) DM5G43H MT DTT DM5G43H MA Inhibitor DM5G43H RN An Overview of Tubulin Inhibitors That Interact with the Colchicine Binding Site. Pharm Res. 2012 November; 29(11): 2943-2971. DM5G43H RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3667160/ DMZYVFH DI DMZYVFH DMZYVFH DN DF-1111301 DMZYVFH MI TTQL5VC DMZYVFH MN Platelet-activating factor receptor (PTAFR) DMZYVFH MT DTT DMZYVFH MA Antagonist DMZYVFH RN US patent application no. 2007,0196,421, Soft tissue implants and drug combination compositions, and use thereof. DMZYVFH RU http://www.google.is/patents/US20070196421 DMAR068 DI DMAR068 DMAR068 DN Discodermolide DMAR068 MI TTML2WA DMAR068 MN Tubulin (TUB) DMAR068 MT DTT DMAR068 MA Modulator DMAR068 RN The microtubule-stabilizing agent discodermolide competitively inhibits the binding of paclitaxel (Taxol) to tubulin polymers, enhances tubulin nucleation reactions more potently than paclitaxel, andinhibits the growth of paclitaxel-resistant cells. Mol Pharmacol. 1997 Oct;52(4):613-22. DMAR068 RU https://pubmed.ncbi.nlm.nih.gov/9380024 DME5PXL DI DME5PXL DME5PXL DN DK-507k DME5PXL MI TTIXTO3 DME5PXL MN Staphylococcus Topoisomerase IV (Stap-coc parC) DME5PXL MT DTT DME5PXL MA Modulator DME5PXL RN In Vitro and In Vivo Antibacterial Activities of DK-507k, a Novel Fluoroquinolone DME5PXL RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC296186 DMCK7LM DI DMCK7LM DMCK7LM DN DMP-728 DMCK7LM MI TT38RM1 DMCK7LM MN Glycoprotein IIb/IIIa receptor (GPIIb/IIIa) DMCK7LM MT DTT DMCK7LM MA Modulator DMCK7LM RN Antiplatelet and antithrombotic efficacy of DMP 728, a novel platelet GPIIb/IIIa receptor antagonist. Circulation. 1994 Jan;89(1):3-12. DMCK7LM RU https://www.ncbi.nlm.nih.gov/pubmed/8281661 DMDK6HP DI DMDK6HP DMDK6HP DN DMP-802 DMDK6HP MI TTJA1ZO DMDK6HP MN ITGB3 messenger RNA (ITGB3 mRNA) DMDK6HP MT DTT DMDK6HP MA Inhibitor DMDK6HP RN Platelet glycoprotein IIb-IIIa antagonists as prototypical integrin blockers: novel parenteral and potential oral antithrombotic agents. J Med Chem. 2000 Sep 21;43(19):3453-73. DMDK6HP RU https://pubmed.ncbi.nlm.nih.gov/10999999 DM412S9 DI DM412S9 DM412S9 DN DMP-851 DM412S9 MI TT5FNQT DM412S9 MN Human immunodeficiency virus Protease (HIV PR) DM412S9 MT DTT DM412S9 MA Inhibitor DM412S9 RN Design and selection of DMP 850 and DMP 851: the next generation of cyclic urea HIV protease inhibitors. Chem Biol. 1998 Oct;5(10):597-608. DM412S9 RU https://pubmed.ncbi.nlm.nih.gov/9818151 DMR6INY DI DMR6INY DMR6INY DN DPC 423 DMR6INY MI TTCIHJA DMR6INY MN Coagulation factor Xa (F10) DMR6INY MT DTT DMR6INY MA Inhibitor DMR6INY RN The design and synthesis of noncovalent factor Xa inhibitors. Curr Top Med Chem. 2001 Jun;1(2):137-49. DMR6INY RU https://pubmed.ncbi.nlm.nih.gov/11899249 DMSOHR6 DI DMSOHR6 DMSOHR6 DN DPC-082 DMSOHR6 MI TT84ETX DMSOHR6 MN Human immunodeficiency virus Reverse transcriptase (HIV RT) DMSOHR6 MT DTT DMSOHR6 MA Inhibitor DMSOHR6 RN Expanded-spectrum nonnucleoside reverse transcriptase inhibitors inhibit clinically relevant mutant variants of human immunodeficiency virus type 1. Antimicrob Agents Chemother. 1999 Dec;43(12):2893-7. DMSOHR6 RU https://pubmed.ncbi.nlm.nih.gov/10582878 DMA7DH0 DI DMA7DH0 DMA7DH0 DN DPC-168 DMA7DH0 MI TTD3XFU DMA7DH0 MN C-C chemokine receptor type 3 (CCR3) DMA7DH0 MT DTT DMA7DH0 MA Antagonist DMA7DH0 RN CC chemokine receptor-3 (CCR3) antagonists: improving the selectivity of DPC168 by reducing central ring lipophilicity. Bioorg Med Chem Lett. 2007 Jun 1;17(11):2992-7. DMA7DH0 RU https://pubmed.ncbi.nlm.nih.gov/17418570 DM5HAG0 DI DM5HAG0 DM5HAG0 DN DPC-681 DM5HAG0 MI TT5FNQT DM5HAG0 MN Human immunodeficiency virus Protease (HIV PR) DM5HAG0 MT DTT DM5HAG0 MA Inhibitor DM5HAG0 RN DPC 681 and DPC 684: potent, selective inhibitors of human immunodeficiency virus protease active against clinically relevant mutant variants. Antimicrob Agents Chemother. 2001 Nov;45(11):3021-8. DM5HAG0 RU https://pubmed.ncbi.nlm.nih.gov/11600351 DMS19VG DI DMS19VG DMS19VG DN DPC-684 DMS19VG MI TT5FNQT DMS19VG MN Human immunodeficiency virus Protease (HIV PR) DMS19VG MT DTT DMS19VG MA Inhibitor DMS19VG RN DPC 681 and DPC 684: potent, selective inhibitors of human immunodeficiency virus protease active against clinically relevant mutant variants. Antimicrob Agents Chemother. 2001 Nov;45(11):3021-8. DMS19VG RU https://pubmed.ncbi.nlm.nih.gov/11600351 DMOPM7L DI DMOPM7L DMOPM7L DN DRF 10945 DMOPM7L MI TTJ584C DMOPM7L MN Peroxisome proliferator-activated receptor alpha (PPARA) DMOPM7L MT DTT DMOPM7L MA Agonist DMOPM7L RN Peroxisome proliferator-activated receptors, metabolic syndrome and cardiovascular disease. Future Cardiol. 2010 September; 6(5): 657-691. DMOPM7L RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3246744/ DMS4IBW DI DMS4IBW DMS4IBW DN DS-1442 DMS4IBW MI TTFQAYR DMS4IBW MN Cholesteryl ester transfer protein (CETP) DMS4IBW MT DTT DMS4IBW MA Modulator DMS4IBW RN Ds-1442b is a Novel, Potent Cetp Inhibitor That Reduces Atherosclerosis by Hdl Elevation and Non-hdl Reduction. Circulation. 2012; 126: A11806. DMS4IBW RU http://circ.ahajournals.org/cgi/content/meeting_abstract/126/21_MeetingAbstracts/A11806 DMDAO8E DI DMDAO8E DMDAO8E DN DS-6930 DMDAO8E MI TTZMAO3 DMDAO8E MN Peroxisome proliferator-activated receptor gamma (PPAR-gamma) DMDAO8E MT DTT DMDAO8E MA Modulator DMDAO8E RN Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800036558) DMDAO8E RU http://adisinsight.springer.com/drugs/800036558 DMQK53O DI DMQK53O DMQK53O DN DS-7250 DMQK53O MI TTF8P9I DMQK53O MN Diacylglycerol acyltransferase 1 (DGAT1) DMQK53O MT DTT DMQK53O MA Modulator DMQK53O RN Clinical pipeline report, company report or official report of Daiichi Sankyo. DMQK53O RU http://www.daiichisankyo.com/rd/pipeline/pdf/20130513_Pipeline_EN1.pdf DMN9KXU DI DMN9KXU DMN9KXU DN DU-29894 DMN9KXU MI TTSQIFT DMN9KXU MN 5-HT 1A receptor (HTR1A) DMN9KXU MT DTT DMN9KXU MA Modulator DMN9KXU RN A comparison of the neuro-endocrinological and temperature effects of DU 29894, flesinoxan, sulpiride and haloperidol in normal volunteers. Br J Clin Pharmacol. 1995 Jan;39(1):7-14. DMN9KXU RU https://pubmed.ncbi.nlm.nih.gov/7756102 DMN9KXU DI DMN9KXU DMN9KXU DN DU-29894 DMN9KXU MI TTEX248 DMN9KXU MN Dopamine D2 receptor (D2R) DMN9KXU MT DTT DMN9KXU MA Modulator DMN9KXU RN A comparison of the neuro-endocrinological and temperature effects of DU 29894, flesinoxan, sulpiride and haloperidol in normal volunteers. Br J Clin Pharmacol. 1995 Jan;39(1):7-14. DMN9KXU RU https://pubmed.ncbi.nlm.nih.gov/7756102 DM9S51Q DI DM9S51Q DM9S51Q DN DU-6681 DM9S51Q MI TTJP4SM DM9S51Q MN Bacterial Penicillin binding protein (Bact PBP) DM9S51Q MT DTT DM9S51Q MA Modulator DM9S51Q RN Pharmacokinetics and Safety of Ascending Single Doses of DZ-2640, a New Oral Carbapenem Antibiotic, Administered to Healthy Japanese Subjects. Antimicrob Agents Chemother. 2000 March; 44(3): 578-582. DM9S51Q RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC89729/ DMUMAHC DI DMUMAHC DMUMAHC DN DUP 697 DMUMAHC MI TTVKILB DMUMAHC MN Prostaglandin G/H synthase 2 (COX-2) DMUMAHC MT DTT DMUMAHC MA Inhibitor DMUMAHC RN Current status of COX-2 inhibitors. Mini Rev Med Chem. 2008 Jan;8(1):73-90. DMUMAHC RU https://pubmed.ncbi.nlm.nih.gov/18220987 DM59WQ7 DI DM59WQ7 DM59WQ7 DN DuP-532 DM59WQ7 MI TTGN1ZA DM59WQ7 MN Angiotensin II receptor (AGTR) DM59WQ7 MT DTT DM59WQ7 MA Modulator DM59WQ7 RN DuP 532, an angiotensin II receptor antagonist: first administration and comparison with losartan. Clin Pharmacol Ther. 1997 Jan;61(1):59-69. DM59WQ7 RU https://pubmed.ncbi.nlm.nih.gov/9024174 DMI5EPB DI DMI5EPB DMI5EPB DN DUP-734 DMI5EPB MI TTJQOD7 DMI5EPB MN 5-HT 2A receptor (HTR2A) DMI5EPB MT DTT DMI5EPB MA Modulator DMI5EPB RN Piperidinyltetralin sigma ligands. J Med Chem. 1994 Feb 4;37(3):364-70. DMI5EPB RU https://www.ncbi.nlm.nih.gov/pubmed/7905926 DMI5EPB DI DMI5EPB DMI5EPB DN DUP-734 DMI5EPB MI TT5TPI6 DMI5EPB MN Opioid receptor sigma 1 (OPRS1) DMI5EPB MT DTT DMI5EPB MA Modulator DMI5EPB RN Piperidinyltetralin sigma ligands. J Med Chem. 1994 Feb 4;37(3):364-70. DMI5EPB RU https://www.ncbi.nlm.nih.gov/pubmed/7905926 DMDC4BA DI DMDC4BA DMDC4BA DN DV-7751A DMDC4BA MI TTN6J5F DMDC4BA MN Bacterial DNA gyrase (Bact gyrase) DMDC4BA MT DTT DMDC4BA MA Modulator DMDC4BA RN Antimicrobial activity of DV-7751a, a new fluoroquinolone. DMDC4BA RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC192237 DMXJ54Z DI DMXJ54Z DMXJ54Z DN DW-908e DMXJ54Z MI TTHIZP9 DMXJ54Z MN Integrin alpha-5 (ITGA5) DMXJ54Z MT DTT DMXJ54Z MA Antagonist DMXJ54Z RN WO patent application no. 2008,1439,28, Methods and compositions for treating skin conditions. DMXJ54Z RU http://worldwide.espacenet.com/publicationDetails/biblio?DB=worldwide.espacenet.com&II=0&ND=3&adjacent=true&locale=en_EP&FT=D&date=20081127&CC=WO&NR=2008143928A1&KC=A1 DMI9NZ3 DI DMI9NZ3 DMI9NZ3 DN E2101 DMI9NZ3 MI TTSQIFT DMI9NZ3 MN 5-HT 1A receptor (HTR1A) DMI9NZ3 MT DTT DMI9NZ3 MA Modulator DMI9NZ3 RN In vitro interactions between a potential muscle relaxant E2101 and human cytochromes P450. Drug Metab Dispos. 2002 Jul;30(7):805-13. DMI9NZ3 RU https://pubmed.ncbi.nlm.nih.gov/12065439 DMJWR1I DI DMJWR1I DMJWR1I DN E-3030 DMJWR1I MI TTJ584C DMJWR1I MN Peroxisome proliferator-activated receptor alpha (PPARA) DMJWR1I MT DTT DMJWR1I MA Modulator DMJWR1I RN Antidiabetic and hypolipidemic effects of a novel dual peroxisome proliferator-activated receptor (PPAR) alpha/gamma agonist, E3030, in db/db mice and beagle dogs.J Pharmacol Sci.2008 Sep;108(1):40-8. DMJWR1I RU https://www.ncbi.nlm.nih.gov/pubmed/18776709 DMJWR1I DI DMJWR1I DMJWR1I DN E-3030 DMJWR1I MI TTZMAO3 DMJWR1I MN Peroxisome proliferator-activated receptor gamma (PPAR-gamma) DMJWR1I MT DTT DMJWR1I MA Modulator DMJWR1I RN Antidiabetic and hypolipidemic effects of a novel dual peroxisome proliferator-activated receptor (PPAR) alpha/gamma agonist, E3030, in db/db mice and beagle dogs.J Pharmacol Sci.2008 Sep;108(1):40-8. DMJWR1I RU https://www.ncbi.nlm.nih.gov/pubmed/18776709 DM79MI4 DI DM79MI4 DM79MI4 DN E-6087 DM79MI4 MI TTVKILB DM79MI4 MN Prostaglandin G/H synthase 2 (COX-2) DM79MI4 MT DTT DM79MI4 MA Inhibitor DM79MI4 RN Enantioselective HPLC determination of E-6087, a new COX-2 inhibitor, in human plasma: Validation and pharmacokinetic application. Chirality. 2004 May 15;16(5):302-8. DM79MI4 RU https://pubmed.ncbi.nlm.nih.gov/15069660 DMSOH09 DI DMSOH09 DMSOH09 DN Ebalzotan DMSOH09 MI TTSQIFT DMSOH09 MN 5-HT 1A receptor (HTR1A) DMSOH09 MT DTT DMSOH09 MA Agonist DMSOH09 RN The pharmacological profile of (R)-3,4-dihydro-N-isopropyl-3-(N-isopropyl-N-propylamino)-2H-1-benzopyran-5-carboxamide, a selective 5-hydroxytryptamine(1A) receptor agonist. J Pharmacol Exp Ther. 2001 Dec;299(3):883-93. DMSOH09 RU https://pubmed.ncbi.nlm.nih.gov/11714872 DMURVE8 DI DMURVE8 DMURVE8 DN Elacridar DMURVE8 MI TT3OT40 DMURVE8 MN Multidrug resistance protein 1 (ABCB1) DMURVE8 MT DTT DMURVE8 MA Inhibitor DMURVE8 RN 2-[(3-Methoxyphenylethyl)phenoxy]-based ABCB1 inhibitors: effect of different basic side-chains on their biological properties. J Med Chem. 2008 Dec 11;51(23):7602-13. DMURVE8 RU https://pubmed.ncbi.nlm.nih.gov/19053888 DMWRQG7 DI DMWRQG7 DMWRQG7 DN Eltenac DMWRQG7 MI TTK0943 DMWRQG7 MN Prostaglandin G/H synthase (COX) DMWRQG7 MT DTT DMWRQG7 MA Modulator DMWRQG7 RN Effect of eltenac in horses with induced endotoxaemia. Equine Vet J Suppl. 2000 Jun;(32):26-31. DMWRQG7 RU https://pubmed.ncbi.nlm.nih.gov/11202378 DM2V5XP DI DM2V5XP DM2V5XP DN Emakalim DM2V5XP MI TT1VOHK DM2V5XP MN Potassium channel unspecific (KC) DM2V5XP MT DTT DM2V5XP MA Opener DM2V5XP RN Therapeutic potential of potassium channel activators in coronary heart disease. Eur Heart J. 1994 Aug;15 Suppl C:82-8. DM2V5XP RU https://pubmed.ncbi.nlm.nih.gov/7995277 DMQH8L2 DI DMQH8L2 DMQH8L2 DN EMD-503982 DMQH8L2 MI TTCIHJA DMQH8L2 MN Coagulation factor Xa (F10) DMQH8L2 MT DTT DMQH8L2 MA Inhibitor DMQH8L2 RN Semuloparin for the prevention of venous thromboembolic events in cancer patients. Drugs Today (Barc). 2012 Jul;48(7):451-7. DMQH8L2 RU https://pubmed.ncbi.nlm.nih.gov/22844656 DMVS8IE DI DMVS8IE DMVS8IE DN EMD-53998 DMVS8IE MI TT06AWU DMVS8IE MN Phosphodiesterase 3A (PDE3A) DMVS8IE MT DTT DMVS8IE MA Inhibitor DMVS8IE RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015 DMVS8IE RU https://www.accessdata.fda.gov/scripts/cder/drugsatfda/ DMFGTMR DI DMFGTMR DMFGTMR DN Eptapirone DMFGTMR MI TTSQIFT DMFGTMR MN 5-HT 1A receptor (HTR1A) DMFGTMR MT DTT DMFGTMR MA Agonist DMFGTMR RN The use of sleep measures to compare a new 5HT1A agonist with buspirone in humans. J Psychopharmacol. 2005 Nov;19(6):609-13. DMFGTMR RU https://pubmed.ncbi.nlm.nih.gov/16272182 DM3LKAR DI DM3LKAR DM3LKAR DN ER-35786 DM3LKAR MI TTJP4SM DM3LKAR MN Bacterial Penicillin binding protein (Bact PBP) DM3LKAR MT DTT DM3LKAR MA Inhibitor DM3LKAR RN In vitro and in vivo antibacterial activities of ER-35786, a new antipseudomonal carbapenem. Antimicrob Agents Chemother. 1997 Feb;41(2):298-307. DM3LKAR RU https://pubmed.ncbi.nlm.nih.gov/9021183 DMGX08C DI DMGX08C DMGX08C DN ERB-196 DMGX08C MI TTOM3J0 DMGX08C MN Estrogen receptor beta (ESR2) DMGX08C MT DTT DMGX08C MA Agonist DMGX08C RN WAY-202196, a selective estrogen receptor-beta agonist, protects against death in experimental septic shock. Crit Care Med. 2006 Aug;34(8):2188-93. DMGX08C RU https://pubmed.ncbi.nlm.nih.gov/16755255 DMW9LHG DI DMW9LHG DMW9LHG DN ES-285 DMW9LHG MI TTFNDGV DMW9LHG MN Transforming protein RhoA (RHOA) DMW9LHG MT DTT DMW9LHG MA Inhibitor DMW9LHG RN Spisulosine (ES-285) induces prostate tumor PC-3 and LNCaP cell death by de novo synthesis of ceramide and PKCzeta activation. Eur J Pharmacol. 2008 Apr 28;584(2-3):237-45. DMW9LHG RU https://pubmed.ncbi.nlm.nih.gov/18343365 DM9450Z DI DM9450Z DM9450Z DN EVT-103 DM9450Z MI TTN9D8E DM9450Z MN Glutamate receptor ionotropic NMDA 2B (NMDAR2B) DM9450Z MT DTT DM9450Z MA Antagonist DM9450Z RN Clinical pipeline report, company report or official report of Evotec. DM9450Z RU https://www.evotec.com/archive/en/Press-releases/2009/Evotec-starts-Phase-I-with-EVT-103-an-NR2B-selective-NMDA-receptor-antagonist/1956/1 DMCZ8SF DI DMCZ8SF DMCZ8SF DN EVT-301 DMCZ8SF MI TTGP7BY DMCZ8SF MN Monoamine oxidase type B (MAO-B) DMCZ8SF MT DTT DMCZ8SF MA Inhibitor DMCZ8SF RN Assessment of MAO-B occupancy in the brain with PET and [11C]-L-deprenyl-D2: a dose-finding study with a novel MAO-B inhibitor, EVT 301. Clin Pharmacol Ther. 2009 May;85(5):506-12. DMCZ8SF RU https://pubmed.ncbi.nlm.nih.gov/19129751 DMLRF7U DI DMLRF7U DMLRF7U DN F-11105 DMLRF7U MI TTK0943 DMLRF7U MN Prostaglandin G/H synthase (COX) DMLRF7U MT DTT DMLRF7U MA Inhibitor DMLRF7U RN US patent application no. 6,673,908, Tumor necrosis factor receptor 2. DMLRF7U RU http://www.google.com/patents/US6673908 DMPC9K3 DI DMPC9K3 DMPC9K3 DN F-1394 DMPC9K3 MI TTMF541 DMPC9K3 MN Liver carboxylesterase (CES1) DMPC9K3 MT DTT DMPC9K3 MA Modulator DMPC9K3 RN ACAT inhibitor F-1394 prevents intimal hyperplasia induced by balloon injury in rabbits. J Lipid Res. 2001 Apr;42(4):480-8. DMPC9K3 RU https://pubmed.ncbi.nlm.nih.gov/11290819 DMMG6W5 DI DMMG6W5 DMMG6W5 DN F-50040 DMMG6W5 MI TT362RB DMMG6W5 MN MART-1 melanoma antigen (MLANA) DMMG6W5 MT DTT DMMG6W5 MA Modulator DMMG6W5 RN Stability and CTL-activity of P40/ELA melanoma vaccine candidate. Biologicals. 2001 Sep-Dec;29(3-4):293-8. DMMG6W5 RU https://pubmed.ncbi.nlm.nih.gov/11851331 DMMG6W5 DI DMMG6W5 DMMG6W5 DN F-50040 DMMG6W5 MI TTY7ZHS DMMG6W5 MN Toll-like receptor 2 (TLR2) DMMG6W5 MT DTT DMMG6W5 MA Modulator DMMG6W5 RN Stability and CTL-activity of P40/ELA melanoma vaccine candidate. Biologicals. 2001 Sep-Dec;29(3-4):293-8. DMMG6W5 RU https://pubmed.ncbi.nlm.nih.gov/11851331 DM76GRQ DI DM76GRQ DM76GRQ DN Farampator DM76GRQ MI TTVPQTF DM76GRQ MN Glutamate receptor AMPA 1 (GRIA1) DM76GRQ MT DTT DM76GRQ MA Binder DM76GRQ RN The pipeline and future of drug development in schizophrenia. Mol Psychiatry. 2007 Oct;12(10):904-22. DM76GRQ RU https://pubmed.ncbi.nlm.nih.gov/17667958 DMEX12T DI DMEX12T DMEX12T DN FC EPO DMEX12T MI TTQG4NR DMEX12T MN Erythropoietin (EPO) DMEX12T MT DTT DMEX12T MA Agonist DMEX12T RN Detection of EPO-Fc fusion protein in human blood: screening and confirmation protocols for sports drug testing. Drug Test Anal. 2012 Nov;4(11):818-29. DMEX12T RU https://pubmed.ncbi.nlm.nih.gov/22764129 DMSFA7L DI DMSFA7L DMSFA7L DN FCE-28161 DMSFA7L MI TTML2WA DMSFA7L MN Tubulin (TUB) DMSFA7L MT DTT DMSFA7L MA Modulator DMSFA7L RN CN patent application no. 101065129, A combination of n-(3-metoxy-5-methylpyrazin-2-yl)-2-(4-[1,3,4-oxadiazol-2-yl]phenyl)pyridine-3-sulphonamide and an anti-mitotic agent for the treatment of cancer. DMSFA7L RU http://www.google.com/patents/CN101065129B?cl=en DMC3DVB DI DMC3DVB DMC3DVB DN Figitumumab DMC3DVB MI TTHRID2 DMC3DVB MN Insulin-like growth factor I receptor (IGF1R) DMC3DVB MT DTT DMC3DVB MA Inhibitor DMC3DVB RN Pfizer. Product Development Pipeline. March 31 2009. DMC3DVB RU http://media.pfizer.com/files/research/pipeline/2009_0331/pipeline_2009_0331.pdf DMVL5RC DI DMVL5RC DMVL5RC DN FK-041 DMVL5RC MI TTJP4SM DMVL5RC MN Bacterial Penicillin binding protein (Bact PBP) DMVL5RC MT DTT DMVL5RC MA Inhibitor DMVL5RC RN In vitro antibacterial activity of FK041, a new orally active cephalosporin. J Antibiot (Tokyo). 1999 Jul;52(7):649-59. DMVL5RC RU https://pubmed.ncbi.nlm.nih.gov/10513845 DMB5HMS DI DMB5HMS DMB5HMS DN FK-973 DMB5HMS MI TTUTN1I DMB5HMS MN Human Deoxyribonucleic acid (hDNA) DMB5HMS MT DTT DMB5HMS MA Binder DMB5HMS RN Specific metabolic activation of FK973, a new antitumor antibiotic, in L1210 leukemia cells. Jpn J Pharmacol. 1990 Aug;53(4):463-72. DMB5HMS RU https://pubmed.ncbi.nlm.nih.gov/2214370 DMKWTPX DI DMKWTPX DMKWTPX DN FLM-5011 DMKWTPX MI TTG3K2U DMKWTPX MN Lipoxygenase (ALOX) DMKWTPX MT DTT DMKWTPX MA Modulator DMKWTPX RN Lipoxygenase inhibitor FLM 5011, an effective protectant of myocardial microvessels against ischemia-reperfusion injury. Exp Toxicol Pathol. 2000 Mar;52(1):27-36. DMKWTPX RU https://pubmed.ncbi.nlm.nih.gov/10779150 DM5FW8Y DI DM5FW8Y DM5FW8Y DN FR-158999 DM5FW8Y MI TT38RM1 DM5FW8Y MN Glycoprotein IIb/IIIa receptor (GPIIb/IIIa) DM5FW8Y MT DTT DM5FW8Y MA Antagonist DM5FW8Y RN QSAR study of the peptidic fibrinogen inhibitors FK633, FR158999 and related derivatives, using a novel and useful hydrophobic descriptor (logPmw). Bioorganic & Medicinal Chemistry Letters Volume 8, Issue 18, 22 September 1998, Pages 2483-2488. DM5FW8Y RU http://www.sciencedirect.com/science/article/pii/S0960894X98004053 DM69OR8 DI DM69OR8 DM69OR8 DN FR167653 DM69OR8 MI TTPLTSQ DM69OR8 MN Neutrophil elastase (NE) DM69OR8 MT DTT DM69OR8 MA Inhibitor DM69OR8 RN Neutrophil elastase inhibitors as treatment for COPD. Expert Opin Investig Drugs. 2002 Jul;11(7):965-80. DM69OR8 RU https://pubmed.ncbi.nlm.nih.gov/12084007 DM69OR8 DI DM69OR8 DM69OR8 DN FR167653 DM69OR8 MI TTQBR95 DM69OR8 MN Stress-activated protein kinase 2a (p38 alpha) DM69OR8 MT DTT DM69OR8 MA Inhibitor DM69OR8 RN Prevention of the onset and progression of collagen-induced arthritis in rats by the potent p38 mitogen-activated protein kinase inhibitor FR167653. Arthritis Rheum. 2003 Sep;48(9):2670-81. DM69OR8 RU https://pubmed.ncbi.nlm.nih.gov/13130488 DMDW64X DI DMDW64X DMDW64X DN FT-105 DMDW64X MI TTZOPHG DMDW64X MN Insulin (INS) DMDW64X MT DTT DMDW64X MA Modulator DMDW64X RN Degludec insulin: A novel basal insulin. Indian J Endocrinol Metab. 2011 July; 15(Suppl1): S12-S16. DMDW64X RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3152187/ DMCZAJW DI DMCZAJW DMCZAJW DN Garnocestim DMCZAJW MI TTBID49 DMCZAJW MN C-X-C chemokine receptor type 4 (CXCR4) DMCZAJW MT DTT DMCZAJW MA Modulator DMCZAJW RN CN patent application no. 101094684, With the combination of chemokine activation progenitor cells/stem cells. DMCZAJW RU https://www.google.com.ar/patents/CN101094684A DM041IZ DI DM041IZ DM041IZ DN GED-aPC DM041IZ MI TTZUXYS DM041IZ MN Vitamin K-dependent protein C (PROC) DM041IZ MT DTT DM041IZ MA Modulator DM041IZ RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2396). DM041IZ RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2396 DMNFWR1 DI DMNFWR1 DMNFWR1 DN Gedocarnil DMNFWR1 MI TTNJYV2 DMNFWR1 MN Gamma-aminobutyric acid receptor (GAR) DMNFWR1 MT DTT DMNFWR1 MA Modulator DMNFWR1 RN US patent application no. US20040102438 A1. DMNFWR1 RU https://www.google.com.ar/patents/US20040102438 DM4ZDVY DI DM4ZDVY DM4ZDVY DN Gem 92 DM4ZDVY MI TTFGZB6 DM4ZDVY MN Human immunodeficiency virus GAG protein (HIV gag) DM4ZDVY MT DTT DM4ZDVY MA Modulator DM4ZDVY RN Technology evaluation: GEM-92, Hybridon Inc. Curr Opin Mol Ther. 1999 Aug;1(4):521-3. DM4ZDVY RU https://www.ncbi.nlm.nih.gov/pubmed/11713769 DM520D8 DI DM520D8 DM520D8 DN Gevotroline DM520D8 MI TT5TPI6 DM520D8 MN Opioid receptor sigma 1 (OPRS1) DM520D8 MT DTT DM520D8 MA Modulator DM520D8 RN Sigma receptor ligands alter concentrations of corticosterone in plasma in the rat. Neuropharmacology. 1991 Jan;30(1):79-87. DM520D8 RU https://www.ncbi.nlm.nih.gov/pubmed/1675451 DMSGUY9 DI DMSGUY9 DMSGUY9 DN Goxalapladib DMSGUY9 MI TTDNFMT DMSGUY9 MN Platelet-activating factor acetylhydrolase (PLA2G7) DMSGUY9 MT DTT DMSGUY9 MA Modulator DMSGUY9 RN Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800020582) DMSGUY9 RU http://adisinsight.springer.com/drugs/800020582 DMRNI6K DI DMRNI6K DMRNI6K DN GR-127607 DMRNI6K MI TTSQIFT DMRNI6K MN 5-HT 1A receptor (HTR1A) DMRNI6K MT DTT DMRNI6K MA Agonist DMRNI6K RN Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800003531) DMRNI6K RU http://adisinsight.springer.com/drugs/800003531 DMWY2F6 DI DMWY2F6 DMWY2F6 DN GR-253035 DMWY2F6 MI TTVKILB DMWY2F6 MN Prostaglandin G/H synthase 2 (COX-2) DMWY2F6 MT DTT DMWY2F6 MA Modulator DMWY2F6 RN Role of cyclooxygenases 1 and 2 in the modulation of neuromuscular functions in the distal colon of humans and mice. Gut. 2005 May; 54(5): 608-616. DMWY2F6 RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1774510/ DMUANK9 DI DMUANK9 DMUANK9 DN GR-328713 DMUANK9 MI TTUS1RD DMUANK9 MN Microsomal triglyceride transfer protein (MTTP) DMUANK9 MT DTT DMUANK9 MA Modulator DMUANK9 RN Patent CN101237870 B. DMUANK9 RU http://www.google.com/patents/CN101237870B?cl=en DM13GK8 DI DM13GK8 DM13GK8 DN GR-63799X DM13GK8 MI TTPNGDE DM13GK8 MN Prostaglandin E2 receptor EP3 (PTGER3) DM13GK8 MT DTT DM13GK8 MA Modulator DM13GK8 RN Effects of the prostanoid EP3-receptor agonists M&B 28767 and GR 63799X on infarct size caused by regional myocardial ischaemia in the anaesthetized rat. Br J Pharmacol. 1999 Feb;126(4):849-58. DM13GK8 RU https://pubmed.ncbi.nlm.nih.gov/10193764 DM9C1LQ DI DM9C1LQ DM9C1LQ DN GR-79236 DM9C1LQ MI TTK25J1 DM9C1LQ MN Adenosine A1 receptor (ADORA1) DM9C1LQ MT DTT DM9C1LQ MA Agonist DM9C1LQ RN Effect of the adenosine A1 receptor agonist GR79236 on trigeminal nociception with blink reflex recordings in healthy human subjects. Cephalalgia. 2003 May;23(4):287-92. DM9C1LQ RU https://pubmed.ncbi.nlm.nih.gov/12716347 DMEC6RD DI DMEC6RD DMEC6RD DN GSK1004723 DMEC6RD MI TTTIBOJ DMEC6RD MN Histamine H1 receptor (H1R) DMEC6RD MT DTT DMEC6RD MA Antagonist DMEC6RD RN Clinical pipeline report, company report or official report of GlaxoSmithKline (2009). DMEC6RD RU http://www.gsk.com/investors/product_pipeline/docs/gsk-pipeline-feb09.pdf DMEC6RD DI DMEC6RD DMEC6RD DN GSK1004723 DMEC6RD MI TT9JNIC DMEC6RD MN Histamine H3 receptor (H3R) DMEC6RD MT DTT DMEC6RD MA Antagonist DMEC6RD RN Clinical pipeline report, company report or official report of GlaxoSmithKline (2009). DMEC6RD RU http://www.gsk.com/investors/product_pipeline/docs/gsk-pipeline-feb09.pdf DM7ACJ4 DI DM7ACJ4 DM7ACJ4 DN GSK1018921 DM7ACJ4 MI TTHJTF7 DM7ACJ4 MN Glycine transporter GlyT-1 (SLC6A9) DM7ACJ4 MT DTT DM7ACJ4 MA Blocker DM7ACJ4 RN Clinical pipeline report, company report or official report of GlaxoSmithKline (2009). DM7ACJ4 RU http://www.gsk.com/investors/product_pipeline/docs/gsk-pipeline-feb09.pdf DMI6KQM DI DMI6KQM DMI6KQM DN GSK1059615 DMI6KQM MI TTHBTOP DMI6KQM MN PI3-kinase gamma (PIK3CG) DMI6KQM MT DTT DMI6KQM MA Inhibitor DMI6KQM RN Targeting the phosphoinositide 3-kinase pathway in cancer. Nat Rev Drug Discov. 2009 Aug;8(8):627-44. DMI6KQM RU https://pubmed.ncbi.nlm.nih.gov/19644473 DMBXYKG DI DMBXYKG DMBXYKG DN GSK-1362885 DMBXYKG MI TT31JXP DMBXYKG MN Myophosphorylase (PYGM) DMBXYKG MT DTT DMBXYKG MA Modulator DMBXYKG RN Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41. DMBXYKG RU https://www.ncbi.nlm.nih.gov/pubmed/15950434 DMM7Q3L DI DMM7Q3L DMM7Q3L DN GSK2849466 DMM7Q3L MI TTS64P2 DMM7Q3L MN Androgen receptor (AR) DMM7Q3L MT DTT DMM7Q3L MA Modulator DMM7Q3L RN Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800036899) DMM7Q3L RU http://adisinsight.springer.com/drugs/800036899 DM6E84O DI DM6E84O DM6E84O DN GSK568859 DM6E84O MI TTDNFMT DM6E84O MN Platelet-activating factor acetylhydrolase (PLA2G7) DM6E84O MT DTT DM6E84O MA Modulator DM6E84O RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1432). DM6E84O RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1432 DMRTPY6 DI DMRTPY6 DMRTPY6 DN GSK729327 DMRTPY6 MI TTAN6JD DMRTPY6 MN Glutamate receptor AMPA (GRIA) DMRTPY6 MT DTT DMRTPY6 MA Modulator DMRTPY6 RN Clinical pipeline report, company report or official report of GlaxoSmithKline (2009). DMRTPY6 RU http://www.gsk.com/investors/product_pipeline/docs/gsk-pipeline-feb09.pdf DM2AP64 DI DM2AP64 DM2AP64 DN GSK945237 DM2AP64 MI TTN6J5F DM2AP64 MN Bacterial DNA gyrase (Bact gyrase) DM2AP64 MT DTT DM2AP64 MA Modulator DM2AP64 RN Company report (gsk) DM2AP64 RU http://www.gsk-clinicalstudyregister.com/study/107895#ps DMWJZAP DI DMWJZAP DMWJZAP DN GW-250495 DMWJZAP MI TTPNQAC DMWJZAP MN Estrogen-related receptor-alpha (ESRRA) DMWJZAP MT DTT DMWJZAP MA Agonist DMWJZAP RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 622). DMWJZAP RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=622 DM62T1C DI DM62T1C DM62T1C DN GW-311616 DM62T1C MI TTPLTSQ DM62T1C MN Neutrophil elastase (NE) DM62T1C MT DTT DM62T1C MA Inhibitor DM62T1C RN Neutrophil elastase inhibitors as treatment for COPD. Expert Opin Investig Drugs. 2002 Jul;11(7):965-80. DM62T1C RU https://pubmed.ncbi.nlm.nih.gov/12084007 DMRQVI9 DI DMRQVI9 DMRQVI9 DN GW-473178 DMRQVI9 MI TT6L509 DMRQVI9 MN Coagulation factor IIa (F2) DMRQVI9 MT DTT DMRQVI9 MA Inhibitor DMRQVI9 RN Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800015039) DMRQVI9 RU http://adisinsight.springer.com/drugs/800015039 DMQNX02 DI DMQNX02 DMQNX02 DN GYKI-12743 DMQNX02 MI TT2NUT5 DMQNX02 MN Adrenergic receptor alpha-2C (ADRA2C) DMQNX02 MT DTT DMQNX02 MA Modulator DMQNX02 RN GYKI-12743 a new postsynaptic vascular alpha-adrenoceptor antagonist. Acta Physiol Hung. 1991;77(3-4):257-67. DMQNX02 RU https://pubmed.ncbi.nlm.nih.gov/1684485 DM2RF06 DI DM2RF06 DM2RF06 DN HCV-086 DM2RF06 MI TTMVBWH DM2RF06 MN Hepatitis C virus RNA-directed RNA polymerase (HCV NS5B) DM2RF06 MT DTT DM2RF06 MA Inhibitor DM2RF06 RN Challenges and successes in developing new therapies for hepatitis C. Nature. 2005 Aug 18;436(7053):953-60. DM2RF06 RU https://pubmed.ncbi.nlm.nih.gov/16107835 DMCP2KH DI DMCP2KH DMCP2KH DN HE2100 DMCP2KH MI DERDQWN DMCP2KH MN Dihydrotestosterone oxidoreductase (HSD3B1) DMCP2KH MT DME DMCP2KH MA Metabolism DMCP2KH RN Steroid signalling in the ovarian surface epithelium. Trends Endocrinol Metab. 2005 Sep;16(7):327-33. DMCP2KH RU https://www.ncbi.nlm.nih.gov/pubmed/?term=16054388 DMCP2KH DI DMCP2KH DMCP2KH DN HE2100 DMCP2KH MI TTZAYWL DMCP2KH MN Estrogen receptor (ESR) DMCP2KH MT DTT DMCP2KH MA Inhibitor DMCP2KH RN Androstene-3,5-dienes as ER-beta selective SERMs. Bioorg Med Chem Lett. 2007 Nov 15;17(22):6295-8. DMCP2KH RU https://pubmed.ncbi.nlm.nih.gov/17890084 DMCP2KH DI DMCP2KH DMCP2KH DN HE2100 DMCP2KH MI TTOM3J0 DMCP2KH MN Estrogen receptor beta (ESR2) DMCP2KH MT DTT DMCP2KH MA Inhibitor DMCP2KH RN Androstene-3,5-dienes as ER-beta selective SERMs. Bioorg Med Chem Lett. 2007 Nov 15;17(22):6295-8. DMCP2KH RU https://pubmed.ncbi.nlm.nih.gov/17890084 DM0W2TA DI DM0W2TA DM0W2TA DN HGS-TR2J DM0W2TA MI TTW20TU DM0W2TA MN TRAIL receptor 2 (TRAIL-R2) DM0W2TA MT DTT DM0W2TA RN Enhancement of Glioma Radiation Therapy and Chemotherapy Response with Targeted Antibody Therapy Against Death Receptor 5. Int J Radiat Oncol Biol Phys. 2008 June 1; 71(2): 507-516. DM0W2TA RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2750837/ DMH4ANG DI DMH4ANG DMH4ANG DN HMN-214 DMH4ANG MI TTIYVQP DMH4ANG MN Polo-like kinase 1 (PLK1) DMH4ANG MT DTT DMH4ANG MA Inhibitor DMH4ANG RN Polo-like kinase (PLK) inhibitors in preclinical and early clinical development in oncology. Oncologist. 2009 Jun;14(6):559-70. DMH4ANG RU https://pubmed.ncbi.nlm.nih.gov/19474163 DMKA612 DI DMKA612 DMKA612 DN HMR-3562 DMKA612 MI TTUWYEA DMKA612 MN Bacterial 50S ribosomal RNA (Bact 50S rRNA) DMKA612 MT DTT DMKA612 MA Modulator DMKA612 RN Structure-activity relationships for six ketolide antibiotics. Curr Microbiol. 2001 Mar;42(3):203-10. DMKA612 RU https://pubmed.ncbi.nlm.nih.gov/11270656 DMQOW8H DI DMQOW8H DMQOW8H DN HO-221 DMQOW8H MI TTGPJ0U DMQOW8H MN DNA polymerase alpha catalytic p180 (POLA1) DMQOW8H MT DTT DMQOW8H MA Modulator DMQOW8H RN Effect of novel benzoylphenylurea derivatives on DNA polymerase alpha activity using the synthesome-based in vitro model system. Invest New Drugs. 2003 Nov;21(4):421-8. DMQOW8H RU https://www.ncbi.nlm.nih.gov/pubmed/14586209 DMNC1A3 DI DMNC1A3 DMNC1A3 DN HOE-065 DMNC1A3 MI TTZJD1B DMNC1A3 MN Acetylcholine release (Ach rele) DMNC1A3 MT DTT DMNC1A3 MA Modulator DMNC1A3 RN Effects of the novel compound, Hoe 065, upon impaired learning and memory in rodents. Eur J Pharmacol. 1989 Nov 14;171(1):79-85. DMNC1A3 RU https://pubmed.ncbi.nlm.nih.gov/2612569 DMH32LM DI DMH32LM DMH32LM DN HRC-302 DMH32LM MI TTQO71U DMH32LM MN Hemoglobin (HB) DMH32LM MT DTT DMH32LM MA Modulator DMH32LM RN Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800014790) DMH32LM RU http://adisinsight.springer.com/drugs/800014790 DMQYWAH DI DMQYWAH DMQYWAH DN HRT DMQYWAH MI TTZAYWL DMQYWAH MN Estrogen receptor (ESR) DMQYWAH MT DTT DMQYWAH MA Agonist DMQYWAH RN US patent application no. 2010,0278,784, Methods and compositions for treating skin conditions. DMQYWAH RU https://www.google.com.ar/patents/US20100278784 DMCS06R DI DMCS06R DMCS06R DN HSR-6071 DMCS06R MI TT4IN7L DMCS06R MN Histamine release (His rele) DMCS06R MT DTT DMCS06R MA Modulator DMCS06R RN Inhibitory effect of HSR-6071, a new anti-allergic agent, on experimental asthma in rats and guinea-pigs. J Pharm Pharmacol. 1990 Apr;42(4):236-41. DMCS06R RU https://pubmed.ncbi.nlm.nih.gov/1974289 DMUPOIG DI DMUPOIG DMUPOIG DN HT-1067 DMUPOIG MI TTGP7BY DMUPOIG MN Monoamine oxidase type B (MAO-B) DMUPOIG MT DTT DMUPOIG MA Inhibitor DMUPOIG RN Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800034020) DMUPOIG RU http://adisinsight.springer.com/drugs/800034020 DM9LY4Q DI DM9LY4Q DM9LY4Q DN HuMV833 DM9LY4Q MI TTVJ1D8 DM9LY4Q MN Vascular endothelial growth factor receptor (VEGFR) DM9LY4Q MT DTT DM9LY4Q RN Molecular imaging and biological evaluation of HuMV833 anti-VEGF antibody: implications for trial design of antiangiogenic antibodies. J Natl Cancer Inst. 2002 Oct 2;94(19):1484-93. DM9LY4Q RU https://pubmed.ncbi.nlm.nih.gov/12359857 DMZYA9E DI DMZYA9E DMZYA9E DN ICI-D-6888 DMZYA9E MI TTGN1ZA DMZYA9E MN Angiotensin II receptor (AGTR) DMZYA9E MT DTT DMZYA9E MA Modulator DMZYA9E RN WO patent application no. 1995,0216,09, Treatment of normotensive glaucoma with angiotensin ii antagonists. DMZYA9E RU http://www.google.com.au/patents/WO1995021609A1 DMAU79Q DI DMAU79Q DMAU79Q DN IDEC-131 DMAU79Q MI TTIJP3Q DMAU79Q MN TNF related activation protein (CD40LG) DMAU79Q MT DTT DMAU79Q RN Phase I clinical trial of a monoclonal antibody against CD40-ligand (IDEC-131) in patients with systemic lupus erythematosus. J Rheumatol. 2001 Jan;28(1):95-101. DMAU79Q RU https://pubmed.ncbi.nlm.nih.gov/11196549 DMP8MBW DI DMP8MBW DMP8MBW DN IGANIDIPINE HYDROCHLORIDE DMP8MBW MI TT5HONZ DMP8MBW MN Calcium channel unspecific (CaC) DMP8MBW MT DTT DMP8MBW MA Blocker DMP8MBW RN Improving effects of topical administration of iganidipine, a new calcium channel blocker, on the impaired visual evoked potential after endothelin-1 injection into the vitreous body of rabbits. CurrEye Res. 2000 Feb;20(2):101-8. DMP8MBW RU https://pubmed.ncbi.nlm.nih.gov/10617910 DMRSJ49 DI DMRSJ49 DMRSJ49 DN IL-18BP DMRSJ49 MI TTRICUF DMRSJ49 MN Interleukin-18 (IL18) DMRSJ49 MT DTT DMRSJ49 MA Binder DMRSJ49 RN Emerging drugs for rheumatoid arthritis. Expert Opin Emerg Drugs. 2008 Mar;13(1):175-96. DMRSJ49 RU https://pubmed.ncbi.nlm.nih.gov/18321156 DMQIXD2 DI DMQIXD2 DMQIXD2 DN IMC-1C11 DMQIXD2 MI TTUTJGQ DMQIXD2 MN Vascular endothelial growth factor receptor 2 (KDR) DMQIXD2 MT DTT DMQIXD2 RN Technology evaluation: IMC-1C11, ImClone Systems. Curr Opin Mol Ther. 2001 Aug;3(4):418-24. DMQIXD2 RU https://pubmed.ncbi.nlm.nih.gov/11525567 DM8OYZB DI DM8OYZB DM8OYZB DN Imepitoin DM8OYZB MI TTPTXIN DM8OYZB MN Translocator protein (TSPO) DM8OYZB MT DTT DM8OYZB MA Agonist DM8OYZB RN The pharmacology of imepitoin: the first partial benzodiazepine receptor agonist developed for the treatment of epilepsy. CNS Drugs. 2014 Jan;28(1):29-43. DM8OYZB RU https://pubmed.ncbi.nlm.nih.gov/24357084 DMFACQU DI DMFACQU DMFACQU DN IMS DMFACQU MI TTCAQMW DMFACQU MN Inosine-5'-monophosphate dehydrogenase (IMPDH) DMFACQU MT DTT DMFACQU MA Modulator DMFACQU RN The novel inosine analogue INO-2002 exerts an anti-inflammatory effect in a murine model of acute lung injury. Shock. 2009 Sep;32(3):258-62. DMFACQU RU https://pubmed.ncbi.nlm.nih.gov/19174745 DM8PTUC DI DM8PTUC DM8PTUC DN INCB8696 DM8PTUC MI TTFZYTO DM8PTUC MN C-C chemokine receptor type 2 (CCR2) DM8PTUC MT DTT DM8PTUC MA Antagonist DM8PTUC RN Incyte. Product Development Pipeline. DM8PTUC RU http://www.incyte.com/drugs_product_pipeline.html DMGCUTI DI DMGCUTI DMGCUTI DN INOC-002 DMGCUTI MI TTW1KTD DMGCUTI MN Phosphoric monoester hydrolase (PMH) DMGCUTI MT DTT DMGCUTI MA Inhibitor DMGCUTI RN Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800022435) DMGCUTI RU http://adisinsight.springer.com/drugs/800022435 DMCF0XK DI DMCF0XK DMCF0XK DN IPI-493 DMCF0XK MI TT78R5H DMCF0XK MN Heat shock protein 90 alpha (HSP90A) DMCF0XK MT DTT DMCF0XK MA Inhibitor DMCF0XK RN Clinical pipeline report, company report or official report of AstraZeneca (2009). DMCF0XK RU http://www.astrazeneca.com/_mshost3690701/content/resources/media/investors/AZN-Q2-2009/AZN-Q2-2009-Pipeline.pdf DM8139E DI DM8139E DM8139E DN ITAMELINE DM8139E MI TTZ9SOR DM8139E MN Muscarinic acetylcholine receptor M1 (CHRM1) DM8139E MT DTT DM8139E MA Agonist DM8139E RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015 DM8139E RU https://www.accessdata.fda.gov/scripts/cder/drugsatfda/ DMUNYR7 DI DMUNYR7 DMUNYR7 DN JTK-109 DMUNYR7 MI TTMVBWH DMUNYR7 MN Hepatitis C virus RNA-directed RNA polymerase (HCV NS5B) DMUNYR7 MT DTT DMUNYR7 MA Inhibitor DMUNYR7 RN Benzimidazole derivatives bearing substituted biphenyls as hepatitis C virus NS5B RNA-dependent RNA polymerase inhibitors: structure-activity relationship studies and identification of a potent and highly selective inhibitor JTK-109. J Med Chem. 2006 Jul 27;49(15):4721-36. DMUNYR7 RU https://pubmed.ncbi.nlm.nih.gov/16854079 DMZFEY1 DI DMZFEY1 DMZFEY1 DN JTK-652 DMZFEY1 MI TTMVBWH DMZFEY1 MN Hepatitis C virus RNA-directed RNA polymerase (HCV NS5B) DMZFEY1 MT DTT DMZFEY1 MA Inhibitor DMZFEY1 RN Safety and antiviral activity of JTK-652: a novel HCV infection inhibitor. Antivir Ther. 2010;15(5):765-73. DMZFEY1 RU https://pubmed.ncbi.nlm.nih.gov/20710058 DMEADBG DI DMEADBG DMEADBG DN JTK-656 DMEADBG MI TT5FH9Y DMEADBG MN Human immunodeficiency virus Integrase (HIV IN) DMEADBG MT DTT DMEADBG MA Inhibitor DMEADBG RN US patent application no. 8,497,270, Macrocyclic integrase inhibitors. DMEADBG RU http://www.google.com/patents/US8497270 DM64FX9 DI DM64FX9 DM64FX9 DN JTK-853 DM64FX9 MI TTMVBWH DM64FX9 MN Hepatitis C virus RNA-directed RNA polymerase (HCV NS5B) DM64FX9 MT DTT DM64FX9 MA Inhibitor DM64FX9 RN Preclinical Characterization of JTK-853, a Novel Nonnucleoside Inhibitor of the Hepatitis C Virus RNA-Dependent RNA Polymerase. Antimicrob Agents Chemother. 2012 August; 56(8): 4250-4256. DM64FX9 RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3421577/ DMI7Z1Y DI DMI7Z1Y DMI7Z1Y DN JTT-553 DMI7Z1Y MI TTF8P9I DMI7Z1Y MN Diacylglycerol acyltransferase 1 (DGAT1) DMI7Z1Y MT DTT DMI7Z1Y MA Inhibitor DMI7Z1Y RN JTT-553, a novel Acyl CoA:diacylglycerol acyltransferase (DGAT) 1 inhibitor, improves glucose metabolism in diet-induced obesity and genetic T2DM mice. J Pharmacol Sci. 2015 Sep;129(1):51-8. DMI7Z1Y RU https://pubmed.ncbi.nlm.nih.gov/26354408 DMGP42Q DI DMGP42Q DMGP42Q DN JTT-651 DMGP42Q MI TTZHY6R DMGP42Q MN Glycogen phosphorylase muscle form (GP) DMGP42Q MT DTT DMGP42Q MA Inhibitor DMGP42Q RN Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800026877) DMGP42Q RU http://adisinsight.springer.com/drugs/800026877 DMXUH6W DI DMXUH6W DMXUH6W DN JTV-803 DMXUH6W MI TTCIHJA DMXUH6W MN Coagulation factor Xa (F10) DMXUH6W MT DTT DMXUH6W MA Inhibitor DMXUH6W RN Semuloparin for the prevention of venous thromboembolic events in cancer patients. Drugs Today (Barc). 2012 Jul;48(7):451-7. DMXUH6W RU https://pubmed.ncbi.nlm.nih.gov/22844656 DM37IH5 DI DM37IH5 DM37IH5 DN KN-203 DM37IH5 MI TTKWM86 DM37IH5 MN Opioid receptor mu (MOP) DM37IH5 MT DTT DM37IH5 MA Agonist DM37IH5 RN Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800026307) DM37IH5 RU http://adisinsight.springer.com/drugs/800026307 DM6LTRC DI DM6LTRC DM6LTRC DN KNI-764 DM6LTRC MI TT5FNQT DM6LTRC MN Human immunodeficiency virus Protease (HIV PR) DM6LTRC MT DTT DM6LTRC MA Modulator DM6LTRC RN JE-2147: a dipeptide protease inhibitor (PI) that potently inhibits multi-PI-resistant HIV-1. Proc Natl Acad Sci U S A. 1999 Jul 20;96(15):8675-80. DM6LTRC RU https://www.ncbi.nlm.nih.gov/pubmed/10411934 DMICLMR DI DMICLMR DMICLMR DN KP106 DMICLMR MI TTVBI8W DMICLMR MN Dopamine transporter (DAT) DMICLMR MT DTT DMICLMR MA Agonist DMICLMR RN Treating Attention-Deficit/Hyperactivity Disorder in Adults: Focus on Once-Daily Medications. Prim Care Companion CNS Disord 2011. DMICLMR RU http://www.psychiatrist.com/PCC/article/Pages/2011/v13n06/11r01168.aspx DMMD6LR DI DMMD6LR DMMD6LR DN KR-30450 DMMD6LR MI TT1VOHK DMMD6LR MN Potassium channel unspecific (KC) DMMD6LR MT DTT DMMD6LR MA Opener DMMD6LR RN Cardioprotective effects of KR-30450, a novel K+(ATP) opener, and its major metabolite KR-30818 on isolated rat hearts. Jpn J Pharmacol. 1998 Jan;76(1):65-73. DMMD6LR RU https://pubmed.ncbi.nlm.nih.gov/9517406 DMBH5G3 DI DMBH5G3 DMBH5G3 DN KT2-962 DMBH5G3 MI TT2O84V DMBH5G3 MN Thromboxane A2 receptor (TBXA2R) DMBH5G3 MT DTT DMBH5G3 MA Antagonist DMBH5G3 RN Azulene derivatives as TXA2/PGH2 receptor antagonists--II. Synthesis and biological activity of 6-mono- and 6-dihydroxylated-isopropylazulenes. Bioorg Med Chem. 1996 Apr;4(4):575-91. DMBH5G3 RU https://pubmed.ncbi.nlm.nih.gov/8735846 DM74BK8 DI DM74BK8 DM74BK8 DN KT-362 DM74BK8 MI TT5HONZ DM74BK8 MN Calcium channel unspecific (CaC) DM74BK8 MT DTT DM74BK8 MA Modulator DM74BK8 RN Comparative cardiac effects of KT-362 and verapamil in isolated heart--correlation to calcium channel current depression. J Cardiovasc Pharmacol. 1991 Oct;18(4):594-604. DM74BK8 RU https://pubmed.ncbi.nlm.nih.gov/1724538 DMG068H DI DMG068H DMG068H DN KW-3635 DMG068H MI TT2O84V DMG068H MN Thromboxane A2 receptor (TBXA2R) DMG068H MT DTT DMG068H MA Antagonist DMG068H RN Antithrombotic effects of KW-3635, a thromboxane A2-receptor antagonist, in guinea pigs. Jpn J Pharmacol. 1994 Jun;65(2):93-8. DMG068H RU https://pubmed.ncbi.nlm.nih.gov/7967232 DM76O23 DI DM76O23 DM76O23 DN KW-6055 DM76O23 MI TTZJD1B DM76O23 MN Acetylcholine release (Ach rele) DM76O23 MT DTT DM76O23 MA Modulator DM76O23 RN Effects of KW-6055, a novel benzylpyridine derivative, on central cholinergic systems. Nihon Yakurigaku Zasshi. 1992 Jun;99(6):435-43. DM76O23 RU https://pubmed.ncbi.nlm.nih.gov/1398340 DM5LRKC DI DM5LRKC DM5LRKC DN L-368899 DM5LRKC MI TTSCIUP DM5LRKC MN Oxytocin receptor (OTR) DM5LRKC MT DTT DM5LRKC MA Antagonist DM5LRKC RN Pharmacokinetics and disposition of the oxytocin receptor antagonist L-368,899 in rats and dogs. Drug Metab Dispos. 1997 Oct;25(10):1113-8. DM5LRKC RU https://pubmed.ncbi.nlm.nih.gov/9321512 DMLHE5A DI DMLHE5A DMLHE5A DN L-692429 DMLHE5A MI TTG4R8V DMLHE5A MN Growth hormone-releasing hormone receptor (GHRHR) DMLHE5A MT DTT DMLHE5A MA Modulator DMLHE5A RN Nonpeptide and peptide growth hormone secretagogues act both as ghrelin receptor agonist and as positive or negative allosteric modulators of ghrel... Mol Endocrinol. 2005 Sep;19(9):2400-11. DMLHE5A RU https://pubmed.ncbi.nlm.nih.gov/15905359 DMBIR5P DI DMBIR5P DMBIR5P DN L-697639 DMBIR5P MI TT84ETX DMBIR5P MN Human immunodeficiency virus Reverse transcriptase (HIV RT) DMBIR5P MT DTT DMBIR5P MA Inhibitor DMBIR5P RN Human pharmacokinetics and tolerability of L-697,639, a non-nucleoside HIV-1 reverse transcriptase inhibitor. Int J Clin Pharmacol Res. 1994;14(2):45-50. DMBIR5P RU https://pubmed.ncbi.nlm.nih.gov/7530697 DMSB0J8 DI DMSB0J8 DMSB0J8 DN L-734217 DMSB0J8 MI TT38RM1 DMSB0J8 MN Glycoprotein IIb/IIIa receptor (GPIIb/IIIa) DMSB0J8 MT DTT DMSB0J8 MA Modulator DMSB0J8 RN Nonpeptide glycoprotein IIb/IIIa inhibitors. 8. Antiplatelet activity and oral antithrombotic efficacy of L-734,217. J Pharmacol Exp Ther. 1996 Jul;278(1):62-73. DMSB0J8 RU https://www.ncbi.nlm.nih.gov/pubmed/8764336 DMHEKIN DI DMHEKIN DMHEKIN DN LASINAVIR DMHEKIN MI TT5FNQT DMHEKIN MN Human immunodeficiency virus Protease (HIV PR) DMHEKIN MT DTT DMHEKIN MA Inhibitor DMHEKIN RN Quantitative determination of CGP 61755, a protease inhibitor, in plasma and urine by high-performance liquid chromatography and fluorescence detection. J Chromatogr B Biomed Sci Appl. 1997 Aug 15;696(1):123-30. DMHEKIN RU https://pubmed.ncbi.nlm.nih.gov/9300916 DMSRD5U DI DMSRD5U DMSRD5U DN LBY-135 DMSRD5U MI TTW20TU DMSRD5U MN TRAIL receptor 2 (TRAIL-R2) DMSRD5U MT DTT DMSRD5U RN Safety, pharmacokinetics, and pharmacodynamics of the DR5 antibody LBY135 alone and in combination with capecitabine in patients with advanced solid tumors. Invest New Drugs. 2014 Feb;32(1):135-44. DMSRD5U RU https://pubmed.ncbi.nlm.nih.gov/23589214 DM41RK2 DI DM41RK2 DM41RK2 DN LG100268 DM41RK2 MI TTW38KT DM41RK2 MN Retinoic acid receptor alpha (RARA) DM41RK2 MT DTT DM41RK2 MA Agonist DM41RK2 RN Placental steroidogenesis in rats is independent of signaling pathways induced by retinoic acids. Gen Comp Endocrinol. 2009 Sep 15;163(3):285-91. DM41RK2 RU https://pubmed.ncbi.nlm.nih.gov/19409899 DM0PXGU DI DM0PXGU DM0PXGU DN LG-101280 DM0PXGU MI TTJ584C DM0PXGU MN Peroxisome proliferator-activated receptor alpha (PPARA) DM0PXGU MT DTT DM0PXGU MA Modulator DM0PXGU RN A peroxisome proliferator-activated receptor alpha/gamma dual agonist with a unique in vitro profile and potent glucose and lipid effects in rodent... Mol Endocrinol. 2005 Jun;19(6):1593-605. DM0PXGU RU https://pubmed.ncbi.nlm.nih.gov/15831517 DM9LEGU DI DM9LEGU DM9LEGU DN LGD2941 DM9LEGU MI TTS64P2 DM9LEGU MN Androgen receptor (AR) DM9LEGU MT DTT DM9LEGU MA Modulator DM9LEGU RN Influence of testosterone and a novel SARM on gene expression in whole blood of Macaca fascicularis. J Steroid Biochem Mol Biol. 2009 Apr;114(3-5):167-73. DM9LEGU RU https://pubmed.ncbi.nlm.nih.gov/19429447 DM7HLFD DI DM7HLFD DM7HLFD DN Licofelone DM7HLFD MI TT2J34L DM7HLFD MN Arachidonate 5-lipoxygenase (5-LOX) DM7HLFD MT DTT DM7HLFD MA Inhibitor DM7HLFD RN Cyclooxygenase (COX) and 5-lipoxygenase (5-LOX) selectivity of COX inhibitors. Prostaglandins Leukot Essent Fatty Acids. 2008 Feb;78(2):99-108. DM7HLFD RU https://pubmed.ncbi.nlm.nih.gov/18280718 DM7HLFD DI DM7HLFD DM7HLFD DN Licofelone DM7HLFD MI DES5XRU DM7HLFD MN Cytochrome P450 2C8 (CYP2C8) DM7HLFD MT DME DM7HLFD MA Metabolism DM7HLFD RN Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. DM7HLFD RU https://www.ncbi.nlm.nih.gov/pubmed/?term=19515014 DM7HLFD DI DM7HLFD DM7HLFD DN Licofelone DM7HLFD MI DE5IED8 DM7HLFD MN Cytochrome P450 2C9 (CYP2C9) DM7HLFD MT DME DM7HLFD MA Metabolism DM7HLFD RN Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. DM7HLFD RU https://www.ncbi.nlm.nih.gov/pubmed/?term=19515014 DM7HLFD DI DM7HLFD DM7HLFD DN Licofelone DM7HLFD MI DEF2WXN DM7HLFD MN UDP-glucuronosyltransferase 1A3 (UGT1A3) DM7HLFD MT DME DM7HLFD MA Metabolism DM7HLFD RN In vitro metabolism of 2-[6-(4-chlorophenyl)-2,2-dimethyl-7-phenyl-2,3-dihydro-1H-pyrrolizin-5-yl] acetic acid (licofelone, ML3000), an inhibitor of cyclooxygenase-1 and -2 and 5-lipoxygenase. Drug Metab Dispos. 2008 May;36(5):894-903. DM7HLFD RU https://www.ncbi.nlm.nih.gov/pubmed/?term=18268076 DMMWCU3 DI DMMWCU3 DMMWCU3 DN Licostinel DMMWCU3 MI TT6L509 DMMWCU3 MN Coagulation factor IIa (F2) DMMWCU3 MT DTT DMMWCU3 MA Inhibitor DMMWCU3 RN Neuroprotective agents for the treatment of acute ischemic stroke. Curr Neurol Neurosci Rep. 2003 Jan;3(1):9-20. DMMWCU3 RU https://pubmed.ncbi.nlm.nih.gov/12507405 DM9WEP5 DI DM9WEP5 DM9WEP5 DN LJP-1082 DM9WEP5 MI TT2OUI9 DM9WEP5 MN Beta-2-glycoprotein 1 (APOH) DM9WEP5 MT DTT DM9WEP5 MA Inhibitor DM9WEP5 RN Emergence of targeted immune therapies for systemic lupus. Expert Opin Emerg Drugs. 2005 Feb;10(1):53-65. DM9WEP5 RU https://pubmed.ncbi.nlm.nih.gov/15757403 DMSL0Y5 DI DMSL0Y5 DMSL0Y5 DN LOR-2501 DMSL0Y5 MI TTWP0NS DMSL0Y5 MN RRM1 messenger RNA (RRM1 mRNA) DMSL0Y5 MT DTT DMSL0Y5 RN Non-covalent complexes of folic acid and oleic acid conjugated polyethylenimine: An efficient vehicle for antisense oligonucleotide delivery. Colloids Surf B Biointerfaces. 2015 Jul 26;135:274-282. DMSL0Y5 RU https://pubmed.ncbi.nlm.nih.gov/26263216 DMGUX5Y DI DMGUX5Y DMGUX5Y DN Lu-AA38466 DMGUX5Y MI TTM7WCE DMGUX5Y MN Ion channel unspecific (IC) DMGUX5Y MT DTT DMGUX5Y MA Modulator DMGUX5Y RN Lundbeck is developing new and promising pharmaceuticals for the treatment of depression, anxiety and psychotic disorders and for new disease areas such as stroke and alcohol dependence. Pipeline report of Lundbeck in 2008. DMGUX5Y RU http://www.e-pages.dk/lundbeck/157/swf/20.swf DMH0AMG DI DMH0AMG DMH0AMG DN Lu-AA44608 DMH0AMG MI TTKG67B DMH0AMG MN Neuropeptide Y receptor (NPYR) DMH0AMG MT DTT DMH0AMG MA Antagonist DMH0AMG RN CA patent application no. 690841, Synthetic bile acid composition, method, and preparation. DMH0AMG RU http://www.google.com/patents/CA2690841A1?cl=en DML86MJ DI DML86MJ DML86MJ DN Lu-AA47070 DML86MJ MI TTM2AOE DML86MJ MN Adenosine A2a receptor (ADORA2A) DML86MJ MT DTT DML86MJ MA Antagonist DML86MJ RN The novel adenosine A2A antagonist Lu AA47070 reverses the motor and motivational effects produced by dopamine D2 receptor blockade. Pharmacol Biochem Behav. 2012 Jan;100(3):498-505. DML86MJ RU https://pubmed.ncbi.nlm.nih.gov/22037410 DMKMIQ6 DI DMKMIQ6 DMKMIQ6 DN LY-315902 DMKMIQ6 MI TTVIMDE DMKMIQ6 MN Glucagon-like peptide 1 receptor (GLP1R) DMKMIQ6 MT DTT DMKMIQ6 MA Modulator DMKMIQ6 RN Glucagon-like peptide-1 analogue LY315902: effect on intestinal motility and release of insulin and somatostatin. Regul Pept. 2002 Jun 15;106(1-3):89-95. DMKMIQ6 RU https://pubmed.ncbi.nlm.nih.gov/12047915 DMNPJL3 DI DMNPJL3 DMNPJL3 DN LY-444711 DMNPJL3 MI TTWDC17 DMNPJL3 MN Growth hormone secretagogue receptor 1 (GHSR) DMNPJL3 MT DTT DMNPJL3 MA Agonist DMNPJL3 RN Synthesis and biological evaluation of an orally active ghrelin agonist that stimulates food consumption and adiposity in rats. Bioorg Med Chem Lett. 2004 Dec 6;14(23):5873-6. DMNPJL3 RU https://pubmed.ncbi.nlm.nih.gov/15501059 DMB1OAR DI DMB1OAR DMB1OAR DN LY-73497 DMB1OAR MI TT84ETX DMB1OAR MN Human immunodeficiency virus Reverse transcriptase (HIV RT) DMB1OAR MT DTT DMB1OAR MA Inhibitor DMB1OAR RN Phenethylthiazolethiourea (PETT) compounds, a new class of HIV-1 reverse transcriptase inhibitors. 1. Synthesis and basic structure-activity relati... J Med Chem. 1995 Dec 8;38(25):4929-36. DMB1OAR RU https://pubmed.ncbi.nlm.nih.gov/8523406 DMVYG5X DI DMVYG5X DMVYG5X DN LY-929 DMVYG5X MI TTJ584C DMVYG5X MN Peroxisome proliferator-activated receptor alpha (PPARA) DMVYG5X MT DTT DMVYG5X MA Agonist DMVYG5X RN CN patent application no. 1882326, Ppar agonists for the treatment of hcv infection. DMVYG5X RU http://www.google.com.ar/patents/CN1882326A?cl=en DMVYG5X DI DMVYG5X DMVYG5X DN LY-929 DMVYG5X MI TTZMAO3 DMVYG5X MN Peroxisome proliferator-activated receptor gamma (PPAR-gamma) DMVYG5X MT DTT DMVYG5X MA Agonist DMVYG5X RN CN patent application no. 1882326, Ppar agonists for the treatment of hcv infection. DMVYG5X RU http://www.google.com.ar/patents/CN1882326A?cl=en DMDUM0Z DI DMDUM0Z DMDUM0Z DN LymphoRad-131 DMDUM0Z MI TTWMIDN DMDUM0Z MN B-cell-activating factor (TNFSF13B) DMDUM0Z MT DTT DMDUM0Z MA Modulator DMDUM0Z RN Fusion Toxin BLyS-Gelonin Inhibits Growth of Malignant Human B Cell Lines In Vitro and In Vivo. PLoS One. 2012; 7(10): e47361. DMDUM0Z RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3467252/ DMP19KT DI DMP19KT DMP19KT DN MBI 1121 DMP19KT MI TTK025N DMP19KT MN Human papillomavirus E1 region messenger RNA (HPV E1 mRNA) DMP19KT MT DTT DMP19KT RN Design and development of antisense drugs. Expert Opin. Drug Discov. 2008 3(10):1189-1207. DMP19KT RU http://www.informahealthcare.com/doi/abs/10.1517/17460441.3.10.1177 DMRIK2Y DI DMRIK2Y DMRIK2Y DN MC-02,479 DMRIK2Y MI TTJP4SM DMRIK2Y MN Bacterial Penicillin binding protein (Bact PBP) DMRIK2Y MT DTT DMRIK2Y MA Inhibitor DMRIK2Y RN RWJ-54428 (MC-02,479), a new cephalosporin with high affinity for penicillin-binding proteins, including PBP 2a, and stability to staphylococcal be... Antimicrob Agents Chemother. 2003 Feb;47(2):658-64. DMRIK2Y RU https://pubmed.ncbi.nlm.nih.gov/12543674 DMUMSFR DI DMUMSFR DMUMSFR DN ME-3277 DMUMSFR MI TT38RM1 DMUMSFR MN Glycoprotein IIb/IIIa receptor (GPIIb/IIIa) DMUMSFR MT DTT DMUMSFR MA Modulator DMUMSFR RN ME3277, a GPIIb/IIIa antagonist reduces cerebral infarction without enhancing intracranial hemorrhage in photothrombotic occlusion of rabbit middle cerebral artery. J Cereb Blood Flow Metab. 2000 Jun;20(6):988-97. DMUMSFR RU https://pubmed.ncbi.nlm.nih.gov/10894182 DMC2V5J DI DMC2V5J DMC2V5J DN Mirisetron maleate DMC2V5J MI TTNXLKE DMC2V5J MN 5-HT 3 receptor (5HT3R) DMC2V5J MT DTT DMC2V5J MA Modulator DMC2V5J RN The effects of 5-HT3 receptor antagonists on cognitive performance in aged monkeys. Neurobiol Aging. 1997 Jan-Feb;18(1):21-8. DMC2V5J RU https://pubmed.ncbi.nlm.nih.gov/8983029 DM23KBM DI DM23KBM DM23KBM DN MIV-701 DM23KBM MI TTDZN01 DM23KBM MN Cathepsin K (CTSK) DM23KBM MT DTT DM23KBM MA Inhibitor DM23KBM RN Medivir designates MIV-710 a Candidate Drug (CD) for Osteoporosis and Osteoarthritis, 2009 DM23KBM RU http://www.medivir.se/v5/en/uptodate/pressrelease.cfm?releaseid=D575F7294C8454BE&year=2009 DMNAJGK DI DMNAJGK DMNAJGK DN MK-0963 DMNAJGK MI TT2A0DR DMNAJGK MN Oxo-5-alpha-steroid 4-dehydrogenase (SRD5A) DMNAJGK MT DTT DMNAJGK MA Inhibitor DMNAJGK RN Pharmacodynamics of MK-0963, a new 5 alpha-reductase inhibitor: effects on serum androgen concentrations. Clin Pharmacol Ther. 1994 Jan;55(1):50-4. DMNAJGK RU https://pubmed.ncbi.nlm.nih.gov/8299317 DMERKWM DI DMERKWM DMERKWM DN MK-434 DMERKWM MI TT2A0DR DMERKWM MN Oxo-5-alpha-steroid 4-dehydrogenase (SRD5A) DMERKWM MT DTT DMERKWM MA Inhibitor DMERKWM RN The effects of progesterone, 4,16-androstadien-3-one and MK-434 on the kinetics of pig testis microsomal testosterone-4-ene-5alpha-reductase activity. J Steroid Biochem Mol Biol. 1997 Mar;60(5-6):353-9. DMERKWM RU https://pubmed.ncbi.nlm.nih.gov/9219928 DMB5NOI DI DMB5NOI DMB5NOI DN MK-6592 DMB5NOI MI TTLYXIT DMB5NOI MN Aurora kinase C (AURKC) DMB5NOI MT DTT DMB5NOI MA Inhibitor DMB5NOI RN Clinical experience with aurora kinase inhibitors: a review. Oncologist. 2009 Aug;14(8):780-93. DMB5NOI RU https://pubmed.ncbi.nlm.nih.gov/19684075 DMG72VK DI DMG72VK DMG72VK DN MLN0415 DMG72VK MI TTJ3E9X DMG72VK MN Inhibitor of nuclear factor kappa-B kinase beta (IKKB) DMG72VK MT DTT DMG72VK MA Modulator DMG72VK RN Company report (Millennium) DMG72VK RU http://investor.millennium.com/phoenix.zhtml?c=80159&p=irol-newsArticle_Print&ID=900341 DMQA5JW DI DMQA5JW DMQA5JW DN MLN-2201 DMQA5JW MI TTIJWR7 DMQA5JW MN Integrin beta-2 (ITGB2) DMQA5JW MT DTT DMQA5JW RN Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800010178) DMQA5JW RU http://adisinsight.springer.com/drugs/800010178 DM2PUYI DI DM2PUYI DM2PUYI DN MN-246 DM2PUYI MI TTMXGCW DM2PUYI MN Adrenergic receptor beta-3 (ADRB3) DM2PUYI MT DTT DM2PUYI MA Agonist DM2PUYI RN CA patent application no. 630818, Pharmaceutical composition for prevention or treatment of neurogenic pain. DM2PUYI RU http://www.google.com/patents/CA2630818A1?cl=en DMKHEQL DI DMKHEQL DMKHEQL DN Mofarotene DMKHEQL MI DEJGDUW DMKHEQL MN Cytochrome P450 1A2 (CYP1A2) DMKHEQL MT DME DMKHEQL MA Metabolism DMKHEQL RN Metabolism of mofarotene in hepatocytes and liver microsomes from different species. Comparison with in vivo data and evaluation of the cytochrome P450 isoenzymes involved in human biotransformation. Drug Metab Dispos. 1995 Oct;23(10):1051-7. DMKHEQL RU https://www.ncbi.nlm.nih.gov/pubmed/?term=8654192 DMKHEQL DI DMKHEQL DMKHEQL DN Mofarotene DMKHEQL MI DE4LYSA DMKHEQL MN Cytochrome P450 3A4 (CYP3A4) DMKHEQL MT DME DMKHEQL MA Metabolism DMKHEQL RN Metabolism of mofarotene in hepatocytes and liver microsomes from different species. Comparison with in vivo data and evaluation of the cytochrome P450 isoenzymes involved in human biotransformation. Drug Metab Dispos. 1995 Oct;23(10):1051-7. DMKHEQL RU https://www.ncbi.nlm.nih.gov/pubmed/?term=8654192 DMKHEQL DI DMKHEQL DMKHEQL DN Mofarotene DMKHEQL MI TT8WZ3Q DMKHEQL MN Mitochondrial gene transcription (MGT) DMKHEQL MT DTT DMKHEQL MA Modulator DMKHEQL RN Down-regulation of mitochondrial gene expression by the anti-tumor arotinoid mofarotene (Ro 40-8757). Int J Cancer. 1994 Sep 15;58(6):891-7. DMKHEQL RU https://pubmed.ncbi.nlm.nih.gov/7927884 DMK91WR DI DMK91WR DMK91WR DN MP-136 DMK91WR MI TTJ584C DMK91WR MN Peroxisome proliferator-activated receptor alpha (PPARA) DMK91WR MT DTT DMK91WR MA Agonist DMK91WR RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 593). DMK91WR RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=593 DMMVG34 DI DMMVG34 DMMVG34 DN MPC-0920 DMMVG34 MI TT6L509 DMMVG34 MN Coagulation factor IIa (F2) DMMVG34 MT DTT DMMVG34 MA Inhibitor DMMVG34 RN Clinical pipeline report, company report or official report of MYRIAD GENETICS, INC. DMMVG34 RU http://investor.myriad.com/secfiling.cfm?filingid=1193125-08-186392&cik= DMCMNKV DI DMCMNKV DMCMNKV DN MPC-9055 DMCMNKV MI TTFGZB6 DMCMNKV MN Human immunodeficiency virus GAG protein (HIV gag) DMCMNKV MT DTT DMCMNKV MA Inhibitor DMCMNKV RN New Small-Molecule Inhibitor Class Targeting Human Immunodeficiency Virus Type 1 Virion Maturation . Antimicrob Agents Chemother. 2009 December; 53(12): 5080-5087. DMCMNKV RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2786326/ DMCJ1B2 DI DMCJ1B2 DMCJ1B2 DN MT-500 DMCJ1B2 MI TT0K1SC DMCJ1B2 MN 5-HT 2B receptor (HTR2B) DMCJ1B2 MT DTT DMCJ1B2 MA Antagonist DMCJ1B2 RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015 DMCJ1B2 RU https://www.accessdata.fda.gov/scripts/cder/drugsatfda/ DMC4RK7 DI DMC4RK7 DMC4RK7 DN MX-4509 DMC4RK7 MI TTS64P2 DMC4RK7 MN Androgen receptor (AR) DMC4RK7 MT DTT DMC4RK7 MA Antagonist DMC4RK7 RN Androgen antagonistic effect of estramustine phosphate (EMP) metabolites on wild-type and mutated androgen receptor. Biochem Pharmacol. 1998 May 1;55(9):1427-33. DMC4RK7 RU https://pubmed.ncbi.nlm.nih.gov/10076535 DMC4RK7 DI DMC4RK7 DMC4RK7 DN MX-4509 DMC4RK7 MI TTZAYWL DMC4RK7 MN Estrogen receptor (ESR) DMC4RK7 MT DTT DMC4RK7 MA Inhibitor DMC4RK7 RN Review of the effects of 17alpha-estradiol in humans: a less feminizing estrogen with neuroprotective potential. Article first published online: 9 FEB 2009. DMC4RK7 RU http://onlinelibrary.wiley.com/doi/10.1002/ddr.20284/pdf DM4MTPU DI DM4MTPU DM4MTPU DN NBI-42902 DM4MTPU MI TT8R70G DM4MTPU MN Gonadotropin-releasing hormone receptor (GNRHR) DM4MTPU MT DTT DM4MTPU MA Inhibitor DM4MTPU RN Discovery of sodium R-(+)-4-{2-[5-(2-fluoro-3-methoxyphenyl)-3-(2-fluoro-6-[trifluoromethyl]benzyl)-4-methyl-2,6-dioxo-3,6-dihydro-2H-pyrimidin-1-yl]-1-phenylethylamino}butyrate (elagolix), a potent and orally available nonpeptide antagonist of the human gonadotropin-releasing hormone receptor. J Med Chem. 2008 Dec 11;51(23):7478-85. DM4MTPU RU https://pubmed.ncbi.nlm.nih.gov/19006286 DMMLESX DI DMMLESX DMMLESX DN ND1251 DMMLESX MI TTNT7K8 DMMLESX MN Nociceptin receptor (OPRL1) DMMLESX MT DTT DMMLESX MA Agonist DMMLESX RN The nociceptin receptor as a potential target in drug design. Drug News Perspect. 2001 Aug;14(6):335-45. DMMLESX RU https://pubmed.ncbi.nlm.nih.gov/12813596 DMMLESX DI DMMLESX DMMLESX DN ND1251 DMMLESX MI TTZSJIV DMMLESX MN Sphingomyelin phosphodiesterase 4 (SMPD4) DMMLESX MT DTT DMMLESX MA Inhibitor DMMLESX RN CenterWatch. Drugs in Clinical Trials Database. CenterWatch. 2008. DMMLESX RU http://www.centerwatch.com/ DMK5VB2 DI DMK5VB2 DMK5VB2 DN Nerisopam DMK5VB2 MI TTSQIFT DMK5VB2 MN 5-HT 1A receptor (HTR1A) DMK5VB2 MT DTT DMK5VB2 MA Agonist DMK5VB2 RN Simultaneous determination of nerisopam, a novel anxiolytic agent showing polymorphic metabolism, and its N-acetyl metabolite from human plasma by a validated high performance liquid chromatographic method. J Chromatogr B Biomed Appl. 1996 Mar 29;678(1):63-72. DMK5VB2 RU https://pubmed.ncbi.nlm.nih.gov/8861657 DMXDLUH DI DMXDLUH DMXDLUH DN NGD-4715 DMXDLUH MI TTX4RTB DMXDLUH MN Melanin-concentrating hormone receptor 1 (MCHR1) DMXDLUH MT DTT DMXDLUH MA Antagonist DMXDLUH RN CenterWatch. Drugs in Clinical Trials Database. CenterWatch. 2008. DMXDLUH RU http://www.centerwatch.com/ DMZ9WLO DI DMZ9WLO DMZ9WLO DN NGD-94-4 DMZ9WLO MI TTE0A2F DMZ9WLO MN Dopamine D4 receptor (D4R) DMZ9WLO MT DTT DMZ9WLO MA Modulator DMZ9WLO RN I. NGD 94-1: identification of a novel, high-affinity antagonist at the human dopamine D4 receptor. J Pharmacol Exp Ther. 1997 Aug;282(2):1011-9. DMZ9WLO RU https://pubmed.ncbi.nlm.nih.gov/9262370 DMMT7BC DI DMMT7BC DMMT7BC DN NIP-520 DMMT7BC MI TTZCG4L DMMT7BC MN Phosphodiesterase 3 (PDE3) DMMT7BC MT DTT DMMT7BC MA Modulator DMMT7BC RN Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41. DMMT7BC RU https://www.ncbi.nlm.nih.gov/pubmed/15950434 DM95NDT DI DM95NDT DM95NDT DN NN-2501 DM95NDT MI TT9O6WS DM95NDT MN Glucagon receptor (GCGR) DM95NDT MT DTT DM95NDT MA Antagonist DM95NDT RN Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800018428) DM95NDT RU http://adisinsight.springer.com/drugs/800018428 DM8Z5VH DI DM8Z5VH DM8Z5VH DN NN8210 DM8Z5VH MI TTHXFA1 DM8Z5VH MN C5a anaphylatoxin chemotactic receptor (C5AR1) DM8Z5VH MT DTT DM8Z5VH MA Modulator DM8Z5VH RN Complement in immune and inflammatory disorders: therapeutic interventions. J Immunol. 2013 Apr 15;190(8):3839-47. DM8Z5VH RU https://pubmed.ncbi.nlm.nih.gov/23564578 DMWDE8K DI DMWDE8K DMWDE8K DN NOStentin DMWDE8K MI TTF10I9 DMWDE8K MN Nitric-oxide synthase inducible (NOS2) DMWDE8K MT DTT DMWDE8K MA Modulator DMWDE8K RN Gene therapy with iNOS provides long-term protection against myocardial infarction without adverse functional consequences. Am J Physiol Heart Circ Physiol. 2006 Feb;290(2):H584-9. DMWDE8K RU https://pubmed.ncbi.nlm.nih.gov/16172153 DMT8IGE DI DMT8IGE DMT8IGE DN NP-252 DMT8IGE MI TT5HONZ DMT8IGE MN Calcium channel unspecific (CaC) DMT8IGE MT DTT DMT8IGE MA Blocker DMT8IGE RN Pharmacological characteristics of NP-252, a new dihydropyridine slow Ca2+ channel blocker, in isolated rabbit vascular smooth muscle and guinea pig myocardium: vascular selectivity. Eur J Pharmacol.1991 Oct 22;203(3):337-44. DMT8IGE RU https://pubmed.ncbi.nlm.nih.gov/1773820 DMXI5YW DI DMXI5YW DMXI5YW DN NP-61 DMXI5YW MI TT1RS9F DMXI5YW MN Acetylcholinesterase (AChE) DMXI5YW MT DTT DMXI5YW MA Inhibitor DMXI5YW RN Potent beta-amyloid modulators. Neurodegener Dis. 2008;5(3-4):153-6. DMXI5YW RU https://pubmed.ncbi.nlm.nih.gov/18322376 DMOMVW9 DI DMOMVW9 DMOMVW9 DN NPC-15669 DMOMVW9 MI TTJAY96 DMOMVW9 MN Polymorphonuclear neutrophil adhesion (PMNA) DMOMVW9 MT DTT DMOMVW9 MA Modulator DMOMVW9 RN NPC 15669-modulated human polymorphonuclear neutrophil functional responsiveness: effects on receptor-coupled signal transduction. Br J Pharmacol. 1995 Apr;114(8):1694-702. DMOMVW9 RU https://pubmed.ncbi.nlm.nih.gov/7599938 DMNL9DS DI DMNL9DS DMNL9DS DN NSD-644 DMNL9DS MI TTVBI8W DMNL9DS MN Dopamine transporter (DAT) DMNL9DS MT DTT DMNL9DS MA Activator DMNL9DS RN NSD-644: Phase I started.NeuroSearch A/S (CSE:NEUR), Ballerup, Denmark, GlaxoSmithKline plc (LSE:GSK; GSK), London, U.K. DMNL9DS RU http://www.biocentury.com/weekinreview/clinicalstatus/2007-12-10/nsd-644-phase-i-started-199006 DMNL9DS DI DMNL9DS DMNL9DS DN NSD-644 DMNL9DS MI TTAWNKZ DMNL9DS MN Norepinephrine transporter (NET) DMNL9DS MT DTT DMNL9DS MA Activator DMNL9DS RN Clinical pipeline report, company report or official report of Neurosearch. DMNL9DS RU http://www.neurosearch.dk/Admin/Public/Download.aspx?file=Files%2FFiler%2FPdf%2FFonds.08-08_-_selskabsmeddelelser_i_2007_-_uk.pdf DMNL9DS DI DMNL9DS DMNL9DS DN NSD-644 DMNL9DS MI TT3ROYC DMNL9DS MN Serotonin transporter (SERT) DMNL9DS MT DTT DMNL9DS MA Activator DMNL9DS RN NSD-644: Phase I started.NeuroSearch A/S (CSE:NEUR), Ballerup, Denmark, GlaxoSmithKline plc (LSE:GSK; GSK), London, U.K. DMNL9DS RU http://www.biocentury.com/weekinreview/clinicalstatus/2007-12-10/nsd-644-phase-i-started-199006 DM1QZKS DI DM1QZKS DM1QZKS DN NTC-801 DM1QZKS MI TT1VOHK DM1QZKS MN Potassium channel unspecific (KC) DM1QZKS MT DTT DM1QZKS MA Inhibitor DM1QZKS RN Effects of the selective KACh channel blocker NTC-801 on atrial fibrillation in a canine model of atrial tachypacing: comparison with class Ic and III drugs. J Cardiovasc Pharmacol. 2014 May;63(5):421-7. DM1QZKS RU https://pubmed.ncbi.nlm.nih.gov/24805146 DMXJO5F DI DMXJO5F DMXJO5F DN NZ-107 DMXJO5F MI TTTWGIX DMXJO5F MN Leukotriene receptor (LTR) DMXJO5F MT DTT DMXJO5F MA Modulator DMXJO5F RN Effects of NZ-107 on tracheal responses to adenosine in the guinea pig. Jpn J Pharmacol. 1991 May;56(1):79-84. DMXJO5F RU https://pubmed.ncbi.nlm.nih.gov/1880989 DMZN6F3 DI DMZN6F3 DMZN6F3 DN Odapipam DMZN6F3 MI TTZFYLI DMZN6F3 MN Dopamine D1 receptor (D1R) DMZN6F3 MT DTT DMZN6F3 MA Antagonist DMZN6F3 RN PET studies of binding competition between endogenous dopamine and the D1 radiotracer [11C]NNC 756. Synapse. 1999 May;32(2):93-109. DMZN6F3 RU https://pubmed.ncbi.nlm.nih.gov/10231129 DM47ELH DI DM47ELH DM47ELH DN Oncolysin M DM47ELH MI TTJVYO3 DM47ELH MN Myeloid cell surface antigen CD33 (CD33) DM47ELH MT DTT DM47ELH MA Modulator DM47ELH RN US patent application no. 6,926,898, Albumin fusion proteins. DM47ELH RU http://www.google.com/patents/US6926898 DML7Q56 DI DML7Q56 DML7Q56 DN ONO-1714 DML7Q56 MI TTF10I9 DML7Q56 MN Nitric-oxide synthase inducible (NOS2) DML7Q56 MT DTT DML7Q56 MA Modulator DML7Q56 RN ONO-1714, a new inducible nitric oxide synthase inhibitor, attenuates diaphragmatic dysfunction associated with cerulein-induced pancreatitis in rats. Crit Care Med. 2001 Jun;29(6):1215-21. DML7Q56 RU https://www.ncbi.nlm.nih.gov/pubmed/11395607 DM8KN2M DI DM8KN2M DM8KN2M DN ONO-2231 DM8KN2M MI TTEBCY8 DM8KN2M MN Poly [ADP-ribose] polymerase (PARP) DM8KN2M MT DTT DM8KN2M MA Modulator DM8KN2M RN Company report (ONO PHARMACEUTICAL) DM8KN2M RU https://www.ono.co.jp/eng/investor/pdf/fr/2006/fi0618.pdf DMUSKY0 DI DMUSKY0 DMUSKY0 DN ONO-4127 DMUSKY0 MI TTNVEIR DMUSKY0 MN Prostaglandin D2 receptor (PTGDR) DMUSKY0 MT DTT DMUSKY0 MA Antagonist DMUSKY0 RN Sleep-wake regulation by prostaglandin D2 and adenosine. Brain Nerve. 2012 Jun;64(6):621-8. DMUSKY0 RU https://pubmed.ncbi.nlm.nih.gov/22647469 DMKRVUN DI DMKRVUN DMKRVUN DN ONO-4817 DMKRVUN MI TT1GHVO DMKRVUN MN Matrix metalloproteinase (MMP) DMKRVUN MT DTT DMKRVUN MA Inhibitor DMKRVUN RN ONO-4817, an orally active matrix metalloproteinase inhibitor, prevents lipopolysaccharide-induced proteoglycan release from the joint cartilage in guinea pigs. Inflamm Res. 2000 Apr;49(4):144-6. DMKRVUN RU https://pubmed.ncbi.nlm.nih.gov/10858013 DMB8T5U DI DMB8T5U DMB8T5U DN ONT-093 DMB8T5U MI TT3OT40 DMB8T5U MN Multidrug resistance protein 1 (ABCB1) DMB8T5U MT DTT DMB8T5U MA Inhibitor DMB8T5U RN A phase I pharmacokinetic study of the P-glycoprotein inhibitor, ONT-093, in combination with paclitaxel in patients with advanced cancer. Invest New Drugs. 2005 Aug;23(4):311-5. DMB8T5U RU https://pubmed.ncbi.nlm.nih.gov/16012790 DMDCOSP DI DMDCOSP DMDCOSP DN OPC-51803 DMDCOSP MI TTK8R02 DMDCOSP MN Vasopressin V2 receptor (V2R) DMDCOSP MT DTT DMDCOSP MA Agonist DMDCOSP RN Effects of OPC-51803, a novel, nonpeptide vasopressin V2-receptor agonist, on micturition frequency in Brattleboro and aged rats. J Pharmacol Sci. 2003 Dec;93(4):484-8. DMDCOSP RU https://pubmed.ncbi.nlm.nih.gov/14737021 DMPDJC8 DI DMPDJC8 DMPDJC8 DN Opterone DMPDJC8 MI TTS64P2 DMPDJC8 MN Androgen receptor (AR) DMPDJC8 MT DTT DMPDJC8 MA Inhibitor DMPDJC8 RN Evidence for a role of testosterone-androgen receptor interactions in mediating masculine sexual behavior in male rats. Endocrinology. 1989 Feb;124(2):618-26. DMPDJC8 RU https://pubmed.ncbi.nlm.nih.gov/2912689 DMB5TL9 DI DMB5TL9 DMB5TL9 DN Orazipone DMB5TL9 MI TTNSUK0 DMB5TL9 MN Protein thiol group (PTG) DMB5TL9 MT DTT DMB5TL9 MA Modulator DMB5TL9 RN Antieosinophilic activity of orazipone. Mol Pharmacol. 2006 Jun;69(6):1861-70. DMB5TL9 RU https://pubmed.ncbi.nlm.nih.gov/16540599 DMQBURK DI DMQBURK DMQBURK DN Ordopidine DMQBURK MI TTEX248 DMQBURK MN Dopamine D2 receptor (D2R) DMQBURK MT DTT DMQBURK MA Modulator DMQBURK RN The dopaminergic stabilizers pridopidine and ordopidine enhance cortico-striatal Arc gene expression. J Neural Transm. 2014 Nov;121(11):1337-47. DMQBURK RU https://pubmed.ncbi.nlm.nih.gov/24817271 DMMYI9U DI DMMYI9U DMMYI9U DN Org-21465 DMMYI9U MI TTEX6LM DMMYI9U MN GABA(A) receptor gamma-3 (GABRG3) DMMYI9U MT DTT DMMYI9U MA Modulator DMMYI9U RN Computer-controlled infusion of ORG 21465, a water soluble steroid i.v. anaesthetic agent, into human volunteers. Br J Anaesth. 1997 Oct;79(4):433-9. DMMYI9U RU https://pubmed.ncbi.nlm.nih.gov/9389258 DMZKTU5 DI DMZKTU5 DMZKTU5 DN Org-31710 DMZKTU5 MI TTUV8G9 DMZKTU5 MN Progesterone receptor (PGR) DMZKTU5 MT DTT DMZKTU5 MA Modulator DMZKTU5 RN Progesterone receptor antagonists Org 31710 and RU 486 increase apoptosis in human periovulatory granulosa cells. Fertil Steril. 2001 Dec;76(6):1225-31. DMZKTU5 RU https://pubmed.ncbi.nlm.nih.gov/11730755 DM5UYI7 DI DM5UYI7 DM5UYI7 DN OX 19 DM5UYI7 MI TTK8R02 DM5UYI7 MN Vasopressin V2 receptor (V2R) DM5UYI7 MT DTT DM5UYI7 MA Agonist DM5UYI7 RN Investigation of mechanism of desmopressin binding in vasopressin V2 receptor versus vasopressin V1a and oxytocin receptors: molecular dynamics simulation of the agonist-bound state in the membrane-aqueous system. Biopolymers. 2006 Apr 5;81(5):321-38. DM5UYI7 RU https://pubmed.ncbi.nlm.nih.gov/16333859 DMF4KPM DI DMF4KPM DMF4KPM DN PA-1050040 DMF4KPM MI TTFGZB6 DMF4KPM MN Human immunodeficiency virus GAG protein (HIV gag) DMF4KPM MT DTT DMF4KPM MA Inhibitor DMF4KPM RN US patent application no. 2015,0105,350, Combination therapy comprising tenofovir alafenamide hemifumarate and cobicistat for use in the treatment of viral infections. DMF4KPM RU http://www.google.com.ar/patents/US20150105350 DM6LQGO DI DM6LQGO DM6LQGO DN Pafenolol DM6LQGO MI TTMXGCW DM6LQGO MN Adrenergic receptor beta-3 (ADRB3) DM6LQGO MT DTT DM6LQGO MA Modulator DM6LQGO RN Presystemic elimination of the beta-blocker pafenolol in the rat after oral and intraperitoneal administration and identification of a main metabolite in both rats and humans. Drug Metab Dispos. 1993May-Jun;21(3):435-40. DM6LQGO RU https://pubmed.ncbi.nlm.nih.gov/8100498 DM6LQGO DI DM6LQGO DM6LQGO DN Pafenolol DM6LQGO MI DTUGYRD DM6LQGO MN P-glycoprotein 1 (ABCB1) DM6LQGO MT DTP DM6LQGO MA Substrate DM6LQGO RN Human intestinal transporter database: QSAR modeling and virtual profiling of drug uptake, efflux and interactions. Pharm Res. 2013 Apr;30(4):996-1007. DM6LQGO RU https://doi.org/10.1007/s11095-012-0935-x DMVFGWM DI DMVFGWM DMVFGWM DN PD-131112 DMVFGWM MI TTN6J5F DMVFGWM MN Bacterial DNA gyrase (Bact gyrase) DMVFGWM MT DTT DMVFGWM MA Modulator DMVFGWM RN Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41. DMVFGWM RU https://www.ncbi.nlm.nih.gov/pubmed/15950434 DM7KJTI DI DM7KJTI DM7KJTI DN PD-153035 DM7KJTI MI TTGKNB4 DM7KJTI MN Epidermal growth factor receptor (EGFR) DM7KJTI MT DTT DM7KJTI MA Modulator DM7KJTI RN EGFR tyrosine kinase inhibitor (PD153035) improves glucose tolerance and insulin action in high-fat diet-fed mice.Diabetes.2009 Dec;58(12):2910-9. DM7KJTI RU https://www.ncbi.nlm.nih.gov/pubmed/19696185 DMO4S6T DI DMO4S6T DMO4S6T DN PF-03814735 DMO4S6T MI TTPS3C0 DMO4S6T MN Aurora kinase A (AURKA) DMO4S6T MT DTT DMO4S6T MA Inhibitor DMO4S6T RN Cell cycle kinases as therapeutic targets for cancer. Nat Rev Drug Discov. 2009 Jul;8(7):547-66. DMO4S6T RU https://pubmed.ncbi.nlm.nih.gov/19568282 DMO4S6T DI DMO4S6T DMO4S6T DN PF-03814735 DMO4S6T MI TT5LS6T DMO4S6T MN Aurora kinase B (AURKB) DMO4S6T MT DTT DMO4S6T MA Inhibitor DMO4S6T RN Cell cycle kinases as therapeutic targets for cancer. Nat Rev Drug Discov. 2009 Jul;8(7):547-66. DMO4S6T RU https://pubmed.ncbi.nlm.nih.gov/19568282 DMD83VY DI DMD83VY DMD83VY DN PF-05212372 DMD83VY MI TT9V5JH DMD83VY MN Phospholipase A2 (PLA2G1B) DMD83VY MT DTT DMD83VY MA Inhibitor DMD83VY RN Phagedena due to leishmaniasis. Immunologic and experimental studies. Ann Dermatol Syphiligr (Paris). 1976;103(1):23-30. DMD83VY RU https://pubmed.ncbi.nlm.nih.gov/793505 DM68PYA DI DM68PYA DM68PYA DN PF-05236812 DM68PYA MI TTE4KHA DM68PYA MN Amyloid beta A4 protein (APP) DM68PYA MT DTT DM68PYA MA Inhibitor DM68PYA RN Passive anti-amyloid immunotherapy in Alzheimer's disease: What are the most promising targets . Immun Ageing. 2013; 10: 18. DM68PYA RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3681567/ DMSE3WP DI DMSE3WP DMSE3WP DN PF-06260414 DMSE3WP MI TTS64P2 DMSE3WP MN Androgen receptor (AR) DMSE3WP MT DTT DMSE3WP MA Modulator DMSE3WP RN Phase I clinical trail of PF-06260414 for treating cachexia. Pfizer Inc. DMSE3WP RU http://www.biocentury.com/products/pf-06260414 DM5R2MG DI DM5R2MG DM5R2MG DN PF-2393296 DM5R2MG MI TTGXH6N DM5R2MG MN GABA(A) receptor delta (GABRD) DM5R2MG MT DTT DM5R2MG MA Agonist DM5R2MG RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 416). DM5R2MG RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=416 DM2V7WH DI DM2V7WH DM2V7WH DN PF-251802 DM2V7WH MI TTYRL6O DM2V7WH MN Glucocorticoid receptor (NR3C1) DM2V7WH MT DTT DM2V7WH MA Agonist DM2V7WH RN Glucocorticoids Pharmacology: Past, Present and Future. Current Pharmaceutical Design. VOLUME 16, ISSUE 32, Page(3540-3553), DOI: 10.2174/138161210793797915. DM2V7WH RU http://www.eurekaselect.com/72976/article DMOQZIW DI DMOQZIW DMOQZIW DN PF-3052334 DMOQZIW MI TTPADOQ DMOQZIW MN HMG-CoA reductase (HMGCR) DMOQZIW MT DTT DMOQZIW MA Inhibitor DMOQZIW RN Substituted pyrazoles as hepatoselective HMG-CoA reductase inhibitors: discovery of (3R,5R)-7-[2-(4-fluoro-phenyl)-4-isopropyl-5-(4-methyl-benzylca... J Med Chem. 2008 Jan 10;51(1):31-45. DMOQZIW RU https://pubmed.ncbi.nlm.nih.gov/18072721 DMCFYZM DI DMCFYZM DMCFYZM DN PF-3185043 DMCFYZM MI TTFQAYR DMCFYZM MN Cholesteryl ester transfer protein (CETP) DMCFYZM MT DTT DMCFYZM MA Inhibitor DMCFYZM RN Pfizer. Product Development Pipeline. March 31 2009. DMCFYZM RU http://media.pfizer.com/files/research/pipeline/2009_0331/pipeline_2009_0331.pdf DMD42MN DI DMD42MN DMD42MN DN PF-3274167 DMD42MN MI TTSCIUP DMD42MN MN Oxytocin receptor (OTR) DMD42MN MT DTT DMD42MN MA Inhibitor DMD42MN RN Oral oxytocin antagonists. J Med Chem. 2010 Sep 23;53(18):6525-38. DMD42MN RU https://pubmed.ncbi.nlm.nih.gov/20550119 DMD42MN DI DMD42MN DMD42MN DN PF-3274167 DMD42MN MI TT4TFGN DMD42MN MN Vasopressin V1a receptor (V1AR) DMD42MN MT DTT DMD42MN MA Inhibitor DMD42MN RN Oral oxytocin antagonists. J Med Chem. 2010 Sep 23;53(18):6525-38. DMD42MN RU https://pubmed.ncbi.nlm.nih.gov/20550119 DMMU1W3 DI DMMU1W3 DMMU1W3 DN PF-3526299 DMMU1W3 MI TTOU65C DMMU1W3 MN Tyrosine-protein kinase SYK (SYK) DMMU1W3 MT DTT DMMU1W3 MA Inhibitor DMMU1W3 RN Pipeline report of RIGEL Pharmaceuticals. DMMU1W3 RU http://www.rigel.com/index.php/pipeline/ DMITYCN DI DMITYCN DMITYCN DN PF-3557156 DMITYCN MI TT1BC3A DMITYCN MN Phosphodiesterase 7A (PDE7A) DMITYCN MT DTT DMITYCN MA Modulator DMITYCN RN Company report (Pfizer pipeline: October 28, 2008) DMITYCN RU https://www.pfizer.com/files/investors/presentations/acr_102808_v2.pdf DMITYCN DI DMITYCN DMITYCN DN PF-3557156 DMITYCN MI TTWIEY9 DMITYCN MN Phosphodiesterase 7B (PDE7B) DMITYCN MT DTT DMITYCN MA Modulator DMITYCN RN Company report (Pfizer pipeline: October 28, 2008) DMITYCN RU https://www.pfizer.com/files/investors/presentations/acr_102808_v2.pdf DMNLAU7 DI DMNLAU7 DMNLAU7 DN PF-4629991 DMNLAU7 MI TT9JZCK DMNLAU7 MN Sphingosine-1-phosphate receptor 1 (S1PR1) DMNLAU7 MT DTT DMNLAU7 MA Agonist DMNLAU7 RN US patent application no. 2010,0158,905, Combination therapy of arthritis with tranilast. DMNLAU7 RU https://www.google.com/patents/US20100158905 DMDOTW0 DI DMDOTW0 DMDOTW0 DN PF-477736 DMDOTW0 MI TTTU902 DMDOTW0 MN Checkpoint kinase-1 (CHK1) DMDOTW0 MT DTT DMDOTW0 MA Inhibitor DMDOTW0 RN Cell cycle kinases as therapeutic targets for cancer. Nat Rev Drug Discov. 2009 Jul;8(7):547-66. DMDOTW0 RU https://pubmed.ncbi.nlm.nih.gov/19568282 DMS7M0U DI DMS7M0U DMS7M0U DN PF-514273 DMS7M0U MI TT6OEDT DMS7M0U MN Cannabinoid receptor 1 (CB1) DMS7M0U MT DTT DMS7M0U MA Modulator DMS7M0U RN Effects of the novel cannabinoid CB1 receptor antagonist PF 514273 on the acquisition and expression of ethanol conditioned place preference. Alcohol. 2014 Aug;48(5):427-31. DMS7M0U RU https://pubmed.ncbi.nlm.nih.gov/24954022 DMB7EIN DI DMB7EIN DMB7EIN DN PF-915275 DMB7EIN MI TTN7BL9 DMB7EIN MN Corticosteroid 11-beta-dehydrogenase 1 (HSD11B1) DMB7EIN MT DTT DMB7EIN MA Inhibitor DMB7EIN RN N-(Pyridin-2-yl) arylsulfonamide inhibitors of 11beta-hydroxysteroid dehydrogenase type 1: Discovery of PF-915275. Bioorg Med Chem Lett. 2009 Jul 1;19(13):3493-7. DMB7EIN RU https://pubmed.ncbi.nlm.nih.gov/19473839 DMAPD6M DI DMAPD6M DMAPD6M DN PLD-147 DMAPD6M MI TTUTN1I DMAPD6M MN Human Deoxyribonucleic acid (hDNA) DMAPD6M MT DTT DMAPD6M MA Binder DMAPD6M RN The new platinum(IV) derivative LA-12 shows stronger inhibitory effect on Hsp90 function compared to cisplatin. Mol Cancer. 2010 Jun 15;9:147. DMAPD6M RU https://pubmed.ncbi.nlm.nih.gov/20550649 DMFKC7L DI DMFKC7L DMFKC7L DN PN-355 DMFKC7L MI TTJSQEF DMFKC7L MN Tyrosine-protein kinase (PTK) DMFKC7L MT DTT DMFKC7L MA Inhibitor DMFKC7L RN WO patent application no. 2005,0502,03, Biological materials and uses thereof. DMFKC7L RU http://worldwide.espacenet.com/publicationDetails/biblio?DB=worldwide.espacenet.com&II=0&ND=3&adjacent=true&locale=en_EP&FT=D&date=20050602&CC=WO&NR=2005050203A2&KC=A2 DMPWG2K DI DMPWG2K DMPWG2K DN PNU-142721 DMPWG2K MI TT84ETX DMPWG2K MN Human immunodeficiency virus Reverse transcriptase (HIV RT) DMPWG2K MT DTT DMPWG2K MA Inhibitor DMPWG2K RN Activation of the human nuclear xenobiotic receptor PXR by the reverse transcriptase-targeted anti-HIV drug PNU-142721. Protein Sci. 2011 Oct;20(10):1713-9. DMPWG2K RU https://pubmed.ncbi.nlm.nih.gov/21805522 DMG2WAX DI DMG2WAX DMG2WAX DN Prostate cancer vaccine DMG2WAX MI TT8R70G DMG2WAX MN Gonadotropin-releasing hormone receptor (GNRHR) DMG2WAX MT DTT DMG2WAX RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 256). DMG2WAX RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=256 DM4LNBQ DI DM4LNBQ DM4LNBQ DN Pyroxamide DM4LNBQ MI TT6R7JZ DM4LNBQ MN Histone deacetylase 1 (HDAC1) DM4LNBQ MT DTT DM4LNBQ MA Inhibitor DM4LNBQ RN Histone deacetylase inhibitors in cancer therapy: latest developments, trends and medicinal chemistry perspective. Anticancer Agents Med Chem. 2007 Sep;7(5):576-92. DM4LNBQ RU https://pubmed.ncbi.nlm.nih.gov/17896917 DMU93JL DI DMU93JL DMU93JL DN R 80122 DMU93JL MI TTZCG4L DMU93JL MN Phosphodiesterase 3 (PDE3) DMU93JL MT DTT DMU93JL MA Modulator DMU93JL RN Inhibition of human cardiac cyclic AMP-phosphodiesterases by R 80122, a new selective cyclic AMP-phosphodiesterase III inhibitor: a comparison with other cardiotonic compounds. J Pharmacol Exp Ther. 1992 Oct;263(1):6-14. DMU93JL RU https://pubmed.ncbi.nlm.nih.gov/1328613 DMHPV1D DI DMHPV1D DMHPV1D DN R-1065 DMHPV1D MI TTWJBZ5 DMHPV1D MN 5-HT 2C receptor (HTR2C) DMHPV1D MT DTT DMHPV1D MA Agonist DMHPV1D RN Antiaversive effects of 5HT2C receptor agonists and fluoxetine in a model of panic-like anxiety in rats. Eur Neuropsychopharmacol. 1998 Aug;8(3):161-8. DMHPV1D RU https://pubmed.ncbi.nlm.nih.gov/9716307 DML7M3S DI DML7M3S DML7M3S DN R-1068 DML7M3S MI TTXEU7H DML7M3S MN GPCR unspecific (GPCR) DML7M3S MT DTT DML7M3S MA Modulator DML7M3S RN R 1068 Roche discontinued, Europe (emesis). R & D Focus Drug New. February 16, 2004 DML7M3S RU http://business.highbeam.com/436989/article-1G1-113216640/r-1068-roche-discontinued-europe DMRHF97 DI DMRHF97 DMRHF97 DN R1204 DMRHF97 MI TTXEU7H DMRHF97 MN GPCR unspecific (GPCR) DMRHF97 MT DTT DMRHF97 MA Modulator DMRHF97 RN Clinical pipeline report, company report or official report of Roche. DMRHF97 RU http://www.roche.com/pages/downloads/investor/pdf/praesentations/irp2702ch.pdf DMT8V9G DI DMT8V9G DMT8V9G DN R1295 DMT8V9G MI TT7ZMI1 DMT8V9G MN Integrin alpha-4/beta-7 (ITGA4/B7) DMT8V9G MT DTT DMT8V9G MA Modulator DMT8V9G RN Vedolizumab: an 47 integrin inhibitor for inflammatory bowel diseases.Ann Pharmacother.2014 Dec;48(12):1629-35. DMT8V9G RU https://www.ncbi.nlm.nih.gov/pubmed/25186623 DM9C6LN DI DM9C6LN DM9C6LN DN R-1479 DM9C6LN MI TT79JGK DM9C6LN MN Mycobacterium RNA polymerase (MycB RNAP) DM9C6LN MT DTT DM9C6LN MA Inhibitor DM9C6LN RN The novel nucleoside analog R1479 (4'-azidocytidine) is a potent inhibitor of NS5B-dependent RNA synthesis and hepatitis C virus replication in cel... J Biol Chem. 2006 Feb 17;281(7):3793-9. DM9C6LN RU https://pubmed.ncbi.nlm.nih.gov/16316989 DM7WPI0 DI DM7WPI0 DM7WPI0 DN R-1487 DM7WPI0 MI TTQBR95 DM7WPI0 MN Stress-activated protein kinase 2a (p38 alpha) DM7WPI0 MT DTT DM7WPI0 MA Inhibitor DM7WPI0 RN Discovery of 6-(2,4-difluorophenoxy)-2-[3-hydroxy-1-(2-hydroxyethyl)propylamino]-8-methyl-8H-pyrido[2,3-d]pyrimidin-7-one (pamapimod) and 6-(2,4-difluorophenoxy)-8-methyl-2-(tetrahydro-2H-pyran-4-ylamino)pyrido[2,3-d]pyrimidin-7(8H)-one (R1487) as orally bioavailable and highly selective inhibitors of p38alpha mitogen-activated protein kinase. J Med Chem. 2011 Apr 14;54(7):2255-65. DM7WPI0 RU https://pubmed.ncbi.nlm.nih.gov/21375264 DM2J5AO DI DM2J5AO DM2J5AO DN R-1518 DM2J5AO MI TTCAQMW DM2J5AO MN Inosine-5'-monophosphate dehydrogenase (IMPDH) DM2J5AO MT DTT DM2J5AO MA Modulator DM2J5AO RN US patent application no. 2010,0092,479, Compositions and methods for treatment of viral diseases. DM2J5AO RU http://www.google.com/patents/US20100092479 DMK25FU DI DMK25FU DMK25FU DN R547 DMK25FU MI TTH6V3D DMK25FU MN Cyclin-dependent kinase 1 (CDK1) DMK25FU MT DTT DMK25FU MA Inhibitor DMK25FU RN Cell cycle kinases as therapeutic targets for cancer. Nat Rev Drug Discov. 2009 Jul;8(7):547-66. DMK25FU RU https://pubmed.ncbi.nlm.nih.gov/19568282 DMK25FU DI DMK25FU DMK25FU DN R547 DMK25FU MI TT7HF4W DMK25FU MN Cyclin-dependent kinase 2 (CDK2) DMK25FU MT DTT DMK25FU MA Inhibitor DMK25FU RN Cell cycle kinases as therapeutic targets for cancer. Nat Rev Drug Discov. 2009 Jul;8(7):547-66. DMK25FU RU https://pubmed.ncbi.nlm.nih.gov/19568282 DMK25FU DI DMK25FU DMK25FU DN R547 DMK25FU MI TT0PG8F DMK25FU MN Cyclin-dependent kinase 4 (CDK4) DMK25FU MT DTT DMK25FU MA Inhibitor DMK25FU RN Cell cycle kinases as therapeutic targets for cancer. Nat Rev Drug Discov. 2009 Jul;8(7):547-66. DMK25FU RU https://pubmed.ncbi.nlm.nih.gov/19568282 DMK25FU DI DMK25FU DMK25FU DN R547 DMK25FU MI TTQYF7G DMK25FU MN Cyclin-dependent kinase 7 (CDK7) DMK25FU MT DTT DMK25FU MA Inhibitor DMK25FU RN Cell cycle kinases as therapeutic targets for cancer. Nat Rev Drug Discov. 2009 Jul;8(7):547-66. DMK25FU RU https://pubmed.ncbi.nlm.nih.gov/19568282 DMF3A6H DI DMF3A6H DMF3A6H DN R-701 DMF3A6H MI TTXEU7H DMF3A6H MN GPCR unspecific (GPCR) DMF3A6H MT DTT DMF3A6H MA Antagonist DMF3A6H RN R 701 Roche discontinued, USA (overactive bladder), R & D Focus Drug News. February 23, 2004 DMF3A6H RU http://business.highbeam.com/436989/article-1G1-113440920/r-701-roche-discontinued-usa DMETAP8 DI DMETAP8 DMETAP8 DN R7232 DMETAP8 MI TTFQAYR DMETAP8 MN Cholesteryl ester transfer protein (CETP) DMETAP8 MT DTT DMETAP8 MA Inhibitor DMETAP8 RN Clinical pipeline report, company report or official report of Roche (2009). DMETAP8 RU http://www.roche.com/research_and_development/pipeline/roche_pharma_pipeline.htm DMTK3DR DI DMTK3DR DMTK3DR DN R-82150 DMTK3DR MI TT84ETX DMTK3DR MN Human immunodeficiency virus Reverse transcriptase (HIV RT) DMTK3DR MT DTT DMTK3DR MA Modulator DMTK3DR RN Kinetic interaction of human immunodeficiency virus type 1 reverse transcriptase with the antiviral tetrahydroimidazo[4,5,1-jk]-[1,4]-benzodiazepin... J Biol Chem. 1991 Aug 5;266(22):14232-6. DMTK3DR RU https://www.ncbi.nlm.nih.gov/pubmed/1713579 DM4WJHY DI DM4WJHY DM4WJHY DN R-82913 DM4WJHY MI TT84ETX DM4WJHY MN Human immunodeficiency virus Reverse transcriptase (HIV RT) DM4WJHY MT DTT DM4WJHY MA Modulator DM4WJHY RN A TIBO derivative, R82913, is a potent inhibitor of HIV-1 reverse transcriptase with heteropolymer templates. Antiviral Res. 1991 Oct;16(3):257-66. DM4WJHY RU https://www.ncbi.nlm.nih.gov/pubmed/1725247 DMJ2ZVW DI DMJ2ZVW DMJ2ZVW DN R-944 DMJ2ZVW MI TT5FNQT DMJ2ZVW MN Human immunodeficiency virus Protease (HIV PR) DMJ2ZVW MT DTT DMJ2ZVW MA Inhibitor DMJ2ZVW RN CN patent application no. 101115713, Hiv protease inhibitors. DMJ2ZVW RU http://www.google.com/patents/CN101115713A?cl=en DMVID8E DI DMVID8E DMVID8E DN Ramorelix DMVID8E MI TT8R70G DMVID8E MN Gonadotropin-releasing hormone receptor (GNRHR) DMVID8E MT DTT DMVID8E MA Antagonist DMVID8E RN Effects of the luteinizing-hormone-releasing hormone (LHRH) antagonist ramorelix (hoe013) and the LHRH agonist buserelin on dimethylbenz[]anthracene-induced mammary carcinoma: studies with slow-release formulations. J Cancer Res Clin Oncol. 1993;119(8):457-62. DMVID8E RU https://pubmed.ncbi.nlm.nih.gov/8509436 DM3V5O2 DI DM3V5O2 DM3V5O2 DN RB-6145 DM3V5O2 MI TTUTN1I DM3V5O2 MN Human Deoxyribonucleic acid (hDNA) DM3V5O2 MT DTT DM3V5O2 MA Binder DM3V5O2 RN Detection of hypoxia by measurement of DNA damage in individual cells from spheroids and murine tumours exposed to bioreductive drugs. II. RSU 1069.. Br J Cancer. 1995 March; 71(3): 537-542. DM3V5O2 RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2033631/ DMR6QMJ DI DMR6QMJ DMR6QMJ DN RC-8800 DMR6QMJ MI TTTHCPF DMR6QMJ MN Cholesterol 24-monooxygenase (CYP46A1) DMR6QMJ MT DTT DMR6QMJ MA Inhibitor DMR6QMJ RN Clinical pipeline report, company report or official report of Boston Millennia Partners. DMR6QMJ RU http://www.bostonmillenniapartners.com/OurPortfolio/Default.asp?PortfolioCompanyID=68 DM0ILRU DI DM0ILRU DM0ILRU DN RDEA-436 DM0ILRU MI TTIDAPM DM0ILRU MN ERK activator kinase 1 (MEK1) DM0ILRU MT DTT DM0ILRU MA Inhibitor DM0ILRU RN Clinical pipeline report, company report or official report of MedKoo Biosciences. DM0ILRU RU http://www.medkoo.com/Anticancer-trials/RDEA-436.htm DM0ILRU DI DM0ILRU DM0ILRU DN RDEA-436 DM0ILRU MI TTTW2NY DM0ILRU MN ERK activator kinase 2 (MEK2) DM0ILRU MT DTT DM0ILRU MA Inhibitor DM0ILRU RN Clinical pipeline report, company report or official report of MedKoo Biosciences. DM0ILRU RU http://www.medkoo.com/Anticancer-trials/RDEA-436.htm DMW08TD DI DMW08TD DMW08TD DN REGN 3048 DMW08TD MI TT85VHW DMW08TD MN MERS-CoV spike glycoprotein (S) DMW08TD MT DTT DMW08TD MA Inhibitor DMW08TD RN Pre- And Postexposure Efficacy of Fully Human Antibodies Against Spike Protein in a Novel Humanized Mouse Model of MERS-CoV Infection. Proc Natl Acad Sci U S A. 2015 Jul 14;112(28):8738-43. doi: 10.1073/pnas.1510830112. DMW08TD RU https://pubmed.ncbi.nlm.nih.gov/26124093 DMLH28J DI DMLH28J DMLH28J DN REGN 3051 DMLH28J MI TT85VHW DMLH28J MN MERS-CoV spike glycoprotein (S) DMLH28J MT DTT DMLH28J MA Inhibitor DMLH28J RN Pre- And Postexposure Efficacy of Fully Human Antibodies Against Spike Protein in a Novel Humanized Mouse Model of MERS-CoV Infection. Proc Natl Acad Sci U S A. 2015 Jul 14;112(28):8738-43. doi: 10.1073/pnas.1510830112. DMLH28J RU https://pubmed.ncbi.nlm.nih.gov/26124093 DMT5VXF DI DMT5VXF DMT5VXF DN Revatropate DMT5VXF MI TTQ13Z5 DMT5VXF MN Muscarinic acetylcholine receptor M3 (CHRM3) DMT5VXF MT DTT DMT5VXF MA Modulator DMT5VXF RN Discovery & development of selective M3 antagonists for clinical use.Life Sci.1997;60(13-14):1053-60. DMT5VXF RU https://www.ncbi.nlm.nih.gov/pubmed/9121347 DMW4G68 DI DMW4G68 DMW4G68 DN RG-201 DMW4G68 MI TT1D5X3 DMW4G68 MN Pneumocystis jirovecii DNA topoisomerase 2 (PJ top2) DMW4G68 MT DTT DMW4G68 MA Modulator DMW4G68 RN US patent application no. 2004,0023,290, Novel therapeutic agents that modulate enzymatic processes. DMW4G68 RU http://www.google.com/patents/US20040023290 DMOI037 DI DMOI037 DMOI037 DN RG-4934 DMOI037 MI TTG0MT6 DMOI037 MN Interleukin-17 (IL17) DMOI037 MT DTT DMOI037 RN Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800032677) DMOI037 RU http://adisinsight.springer.com/drugs/800032677 DMG9U8D DI DMG9U8D DMG9U8D DN RG-7152 DMG9U8D MI TTGKOY9 DMG9U8D MN Leukotriene CysLT1 receptor (CYSLTR1) DMG9U8D MT DTT DMG9U8D MA Antagonist DMG9U8D RN Induction of peroxisomal enzymes by a tetrazole-substituted 2-quinolinylmethoxy leukotriene D4 antagonist. Fundam Appl Toxicol. 1994 Aug;23(2):298-303. DMG9U8D RU https://pubmed.ncbi.nlm.nih.gov/7982537 DMKLPMW DI DMKLPMW DMKLPMW DN RG-7166 DMKLPMW MI TTVBI8W DMKLPMW MN Dopamine transporter (DAT) DMKLPMW MT DTT DMKLPMW MA Inhibitor DMKLPMW RN Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800031598) DMKLPMW RU http://adisinsight.springer.com/drugs/800031598 DMKLPMW DI DMKLPMW DMKLPMW DN RG-7166 DMKLPMW MI TTAWNKZ DMKLPMW MN Norepinephrine transporter (NET) DMKLPMW MT DTT DMKLPMW MA Inhibitor DMKLPMW RN Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800031598) DMKLPMW RU http://adisinsight.springer.com/drugs/800031598 DMKLPMW DI DMKLPMW DMKLPMW DN RG-7166 DMKLPMW MI TT3ROYC DMKLPMW MN Serotonin transporter (SERT) DMKLPMW MT DTT DMKLPMW MA Inhibitor DMKLPMW RN Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800031598) DMKLPMW RU http://adisinsight.springer.com/drugs/800031598 DMGLRK0 DI DMGLRK0 DMGLRK0 DN RG-7167 DMGLRK0 MI TTROQ37 DMGLRK0 MN MAPK/ERK kinase kinase (MAP3K) DMGLRK0 MT DTT DMGLRK0 MA Inhibitor DMGLRK0 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2063). DMGLRK0 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2063 DM12VHC DI DM12VHC DM12VHC DN RG-7185 DM12VHC MI TTQDMX5 DM12VHC MN Prostaglandin D2 receptor 2 (PTGDR2) DM12VHC MT DTT DM12VHC MA Antagonist DM12VHC RN Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800033115) DM12VHC RU http://adisinsight.springer.com/drugs/800033115 DMDPWCM DI DMDPWCM DMDPWCM DN RG-7236 DMDPWCM MI TTUMQVO DMDPWCM MN Cathepsin S (CTSS) DMDPWCM MT DTT DMDPWCM MA Inhibitor DMDPWCM RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2353). DMDPWCM RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2353 DM0LXBW DI DM0LXBW DM0LXBW DN RG-7256 DM0LXBW MI TTWCGQT DM0LXBW MN Serine/threonine-protein kinase B-raf (BRAF) DM0LXBW MT DTT DM0LXBW MA Inhibitor DM0LXBW RN First-in-Man Dose-Escalation Study of the Selective BRAF Inhibitor RG7256 in Patients with BRAF V600-Mutated Advanced Solid Tumors. Target Oncol. 2016 Apr;11(2):149-56. DM0LXBW RU https://pubmed.ncbi.nlm.nih.gov/26310975 DMXMQAT DI DMXMQAT DMXMQAT DN RG-7273 DMXMQAT MI TTJW1GN DMXMQAT MN ATP-binding cassette transporter A1 (ABCA1) DMXMQAT MT DTT DMXMQAT MA Inducer DMXMQAT RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 756). DMXMQAT RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=756 DMUR6OV DI DMUR6OV DMUR6OV DN RG-7356 DMUR6OV MI TTG8DNU DMUR6OV MN Hyaluronic acid receptor (LYVE1) DMUR6OV MT DTT DMUR6OV RN Preclinical evaluation of 89Zr-labeled anti-CD44 monoclonal antibody RG7356 in mice and cynomolgus monkeys: Prelude to Phase 1 clinical studies. MAbs. 2014 Mar-Apr;6(2):567-75. DMUR6OV RU https://pubmed.ncbi.nlm.nih.gov/24492295 DMXRHDL DI DMXRHDL DMXRHDL DN RG7418 DMXRHDL MI TTKSND3 DMXRHDL MN Lectin-like oxidized LDL receptor (OLR1) DMXRHDL MT DTT DMXRHDL MA Modulator DMXRHDL RN Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41. DMXRHDL RU https://www.ncbi.nlm.nih.gov/pubmed/15950434 DMSUV3B DI DMSUV3B DMSUV3B DN RG-7432 DMSUV3B MI TTMVBWH DMSUV3B MN Hepatitis C virus RNA-directed RNA polymerase (HCV NS5B) DMSUV3B MT DTT DMSUV3B MA Inhibitor DMSUV3B RN Chutes and Ladders in Hepatitis C Nucleoside Drug Development. Antiviral Res. 2014 February; 102: 119-147. DMSUV3B RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3910353/ DMW87YE DI DMW87YE DMW87YE DN RG7458 DMW87YE MI TTC1PS3 DMW87YE MN Ovarian carcinoma antigen CA125 (MUC16) DMW87YE MT DTT DMW87YE RN Phase I clinical trail of RG7458 for treating Ovarian cancer. Genentech Inc. DMW87YE RU http://www.biocentury.com/products/rg7458 DMXJAFC DI DMXJAFC DMXJAFC DN RG7602 DMXJAFC MI TTTU902 DMXJAFC MN Checkpoint kinase-1 (CHK1) DMXJAFC MT DTT DMXJAFC MA Modulator DMXJAFC RN National Cancer Institute Drug Dictionary (drug id 701310). DMXJAFC RU http://www.cancer.gov/publications/dictionaries/cancer-drug?cdrid=701310 DMQAK6T DI DMQAK6T DMQAK6T DN Rhodamine-123 DMQAK6T MI DTI7UX6 DMQAK6T MN Breast cancer resistance protein (ABCG2) DMQAK6T MT DTP DMQAK6T MA Substrate DMQAK6T RN Alectinib (CH5424802) antagonizes ABCB1- and ABCG2-mediated multidrug resistance in vitro, in vivo and ex vivo. Exp Mol Med. 2017 Mar 17;49(3):e303. DMQAK6T RU http://www.ncbi.nlm.nih.gov/pubmed/28303028 DMQAK6T DI DMQAK6T DMQAK6T DN Rhodamine-123 DMQAK6T MI DTFI42L DMQAK6T MN Multidrug resistance-associated protein 2 (ABCC2) DMQAK6T MT DTP DMQAK6T MA Substrate DMQAK6T RN Characterization of rhodamine-123, calcein and 5(6)-carboxy-2',7'-dichlorofluorescein (CDCF) export via MRP2 (ABCC2) in MES-SA and A549 cells. Eur J Pharm Sci. 2011 Aug 17;43(5):359-69. DMQAK6T RU https://doi.org/10.1016/j.ejps.2011.05.003 DMQAK6T DI DMQAK6T DMQAK6T DN Rhodamine-123 DMQAK6T MI DTE2B1D DMQAK6T MN Organic anion transporting polypeptide 1A2 (SLCO1A2) DMQAK6T MT DTP DMQAK6T MA Substrate DMQAK6T RN Characterization of rhodamine-123 as a tracer dye for use in in vitro drug transport assays. PLoS One. 2012;7(3):e33253. DMQAK6T RU https://doi.org/10.1371/journal.pone.0033253 DMQAK6T DI DMQAK6T DMQAK6T DN Rhodamine-123 DMQAK6T MI DTUGYRD DMQAK6T MN P-glycoprotein 1 (ABCB1) DMQAK6T MT DTP DMQAK6T MA Substrate DMQAK6T RN Modulation of drug-stimulated ATPase activity of human MDR1/P-glycoprotein by cholesterol. Biochem J. 2007 Jan 15;401(2):597-605. DMQAK6T RU http://www.ncbi.nlm.nih.gov/pubmed/17029589 DMLQD6F DI DMLQD6F DMLQD6F DN RIG-200 DMLQD6F MI TTLBYH1 DMLQD6F MN Guanylate cyclase soluble beta-1 (GUCY1B1) DMLQD6F MT DTT DMLQD6F MA Modulator DMLQD6F RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015 DMLQD6F RU https://www.accessdata.fda.gov/scripts/cder/drugsatfda/ DMBQZTO DI DMBQZTO DMBQZTO DN Rilmakalim DMBQZTO MI TT1VOHK DMBQZTO MN Potassium channel unspecific (KC) DMBQZTO MT DTT DMBQZTO MA Opener DMBQZTO RN Hypotonic stress increases efficacy of rilmakalim, but not pinacidil, to activate ATP-sensitive K(+) current in guinea pig ventricular myocytes. J Pharmacol Sci. 2004 Jun;95(2):189-95. DMBQZTO RU https://pubmed.ncbi.nlm.nih.gov/15215643 DMOVZDY DI DMOVZDY DMOVZDY DN RO-16-8714 DMOVZDY MI TTMXGCW DMOVZDY MN Adrenergic receptor beta-3 (ADRB3) DMOVZDY MT DTT DMOVZDY MA Modulator DMOVZDY RN The novel thermogenic beta-adrenergic agonist Ro 16-8714 increases the interscapular brown-fat beta-receptor-adenylate cyclase and the uncoupling-protein mRNA level in obese (fa/fa) Zucker rats. Biochem J. 1989 Aug 1;261(3):721-4. DMOVZDY RU https://pubmed.ncbi.nlm.nih.gov/2572217 DMAJDPN DI DMAJDPN DMAJDPN DN Ro-31-6930 DMAJDPN MI TT1VOHK DMAJDPN MN Potassium channel unspecific (KC) DMAJDPN MT DTT DMAJDPN MA Opener DMAJDPN RN Evaluation of the bronchodilator properties of Ro 31-6930, a novel potassium channel opener, in the guinea-pig. Br J Pharmacol. 1990 Jun;100(2):289-94. DMAJDPN RU https://pubmed.ncbi.nlm.nih.gov/2379034 DMOX8AD DI DMOX8AD DMOX8AD DN RO-48-8684 DMOX8AD MI TTEX6LM DMOX8AD MN GABA(A) receptor gamma-3 (GABRG3) DMOX8AD MT DTT DMOX8AD MA Modulator DMOX8AD RN Integrated pharmacokinetics and pharmacodynamics of Ro 48-8684, a new benzodiazepine, in comparison with midazolam during first administration to healthy male subjects. Br J Clin Pharmacol. 1997 Nov;44(5):487-93. DMOX8AD RU https://pubmed.ncbi.nlm.nih.gov/9384466 DMMF0OP DI DMMF0OP DMMF0OP DN RO-4987655 DMMF0OP MI TTROQ37 DMMF0OP MN MAPK/ERK kinase kinase (MAP3K) DMMF0OP MT DTT DMMF0OP MA Modulator DMMF0OP RN MEK and the inhibitors: from bench to bedside. J Hematol Oncol. 2013; 6: 27. DMMF0OP RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3626705/ DMP0YNU DI DMP0YNU DMP0YNU DN RO7040547 DMP0YNU MI TT0GVCH DMP0YNU MN Interleukin-13 (IL13) DMP0YNU MT DTT DMP0YNU MA Inhibitor DMP0YNU RN Bispecific antibodies: a mechanistic review of the pipeline. Nat Rev Drug Discov. 2019 Aug;18(8):585-608. DMP0YNU RU https://pubmed.ncbi.nlm.nih.gov/31175342 DMP0YNU DI DMP0YNU DMP0YNU DN RO7040547 DMP0YNU MI TTG0MT6 DMP0YNU MN Interleukin-17 (IL17) DMP0YNU MT DTT DMP0YNU MA Inhibitor DMP0YNU RN Bispecific antibodies: a mechanistic review of the pipeline. Nat Rev Drug Discov. 2019 Aug;18(8):585-608. DMP0YNU RU https://pubmed.ncbi.nlm.nih.gov/31175342 DMMK42O DI DMMK42O DMMK42O DN Roquinimex DMMK42O MI DE4LYSA DMMK42O MN Cytochrome P450 3A4 (CYP3A4) DMMK42O MT DME DMMK42O MA Metabolism DMMK42O RN Identification of cytochrome P4503A as the major subfamily responsible for the metabolism of roquinimex in man. Xenobiotica. 2000 Sep;30(9):905-14. DMMK42O RU https://www.ncbi.nlm.nih.gov/pubmed/?term=11055268 DMMK42O DI DMMK42O DMMK42O DN Roquinimex DMMK42O MI TTF89GD DMMK42O MN Interleukin-2 (IL2) DMMK42O MT DTT DMMK42O MA Modulator DMMK42O RN The novel immunomodulator, Linomide, stimulates interleukin-2-induced human natural killer (NK) cell and PHA-stimulated T cell proliferation from normal donors. Leuk Res. 1996 Jan;20(1):57-63. DMMK42O RU https://pubmed.ncbi.nlm.nih.gov/8632678 DM94R8B DI DM94R8B DM94R8B DN RS-100975 DM94R8B MI TTNGILX DM94R8B MN Adrenergic receptor alpha-1A (ADRA1A) DM94R8B MT DTT DM94R8B MA Antagonist DM94R8B RN In vitro alpha1-adrenoceptor pharmacology of Ro 70-0004 and RS-100329, novel alpha1A-adrenoceptor selective antagonists. Br J Pharmacol. 1999 May;127(1):252-8. DM94R8B RU https://pubmed.ncbi.nlm.nih.gov/10369480 DM4P5WO DI DM4P5WO DM4P5WO DN RS-8891 DM4P5WO MI TTB2MXP DM4P5WO MN Angiotensinogenase renin (REN) DM4P5WO MT DTT DM4P5WO MA Inhibitor DM4P5WO RN Aliskiren, a novel oral renin inhibitor, provides dose-dependent efficacy and placebo-like tolerability in Japanese patients with hypertension. Hypertension Research (2006) 29, 997-1005. doi:10.1291/hypres.29.997 DM4P5WO RU http://www.nature.com/hr/journal/v29/n12/full/hr2006137a.html DMMEAZ2 DI DMMEAZ2 DMMEAZ2 DN RU-58841 DMMEAZ2 MI TTKPW01 DMMEAZ2 MN Androgen receptor messenger RNA (AR mRNA) DMMEAZ2 MT DTT DMMEAZ2 MA Inhibitor DMMEAZ2 RN Rational design and synthesis of 4-((1R,2R)-2-hydroxycyclohexyl)-2(trifluoromethyl)benzonitrile (PF-998425), a novel, nonsteroidal androgen recepto... J Med Chem. 2008 Nov 13;51(21):7010-4. DMMEAZ2 RU https://pubmed.ncbi.nlm.nih.gov/18921992 DMSHYAP DI DMSHYAP DMSHYAP DN RUS 3108 DMSHYAP MI TT5UM29 DMSHYAP MN Perlecan (HSPG) DMSHYAP MT DTT DMSHYAP MA Modulator DMSHYAP RN A perlecan-inducing compound significantly inhibits smooth muscle cell function and in-stent intimal hyperplasia: novel insights into the diverse biological effects of perlecan. EuroIntervention. 2010 May;6(1):134-40. DMSHYAP RU https://pubmed.ncbi.nlm.nih.gov/20542809 DM6BIHE DI DM6BIHE DM6BIHE DN RWJ-56423 DM6BIHE MI TT2WR1T DM6BIHE MN Cationic trypsinogen (PRSS1) DM6BIHE MT DTT DM6BIHE MA Inhibitor DM6BIHE RN Inhibitors of serine proteases as potential therapeutic agents: the road from thrombin to tryptase to cathepsin G. J Med Chem. 2004 Feb 12;47(4):769-87. DM6BIHE RU https://pubmed.ncbi.nlm.nih.gov/14761180 DMRXB8F DI DMRXB8F DMRXB8F DN S-1746 DMRXB8F MI TTAN6JD DMRXB8F MN Glutamate receptor AMPA (GRIA) DMRXB8F MT DTT DMRXB8F MA Antagonist DMRXB8F RN 1,026 experimental treatments in acute stroke. Ann Neurol. 2006 Mar;59(3):467-77. DMRXB8F RU https://pubmed.ncbi.nlm.nih.gov/16453316 DMRXB8F DI DMRXB8F DMRXB8F DN S-1746 DMRXB8F MI TT9IK2Z DMRXB8F MN N-methyl-D-aspartate receptor (NMDAR) DMRXB8F MT DTT DMRXB8F MA Antagonist DMRXB8F RN 1,026 experimental treatments in acute stroke. Ann Neurol. 2006 Mar;59(3):467-77. DMRXB8F RU https://pubmed.ncbi.nlm.nih.gov/16453316 DMX59E8 DI DMX59E8 DMX59E8 DN S-18326 DMX59E8 MI TT6L509 DMX59E8 MN Coagulation factor IIa (F2) DMX59E8 MT DTT DMX59E8 MA Inhibitor DMX59E8 RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015 DMX59E8 RU https://www.accessdata.fda.gov/scripts/cder/drugsatfda/ DML6A8X DI DML6A8X DML6A8X DN S-18327 DML6A8X MI TTEX248 DML6A8X MN Dopamine D2 receptor (D2R) DML6A8X MT DTT DML6A8X MA Modulator DML6A8X RN S18327 (1-[2-[4-(6-fluoro-1, 2-benzisoxazol-3-yl)piperid-1-yl]ethyl]3-phenyl imidazolin-2-one), a novel, potential antipsychotic displaying marked antagonist properties at alpha(1)- and alpha(2)-adrenergic receptors: I. Receptorial, neurochemical, and electrophysiological profile. J Pharmacol Exp Ther. 2000 Jan;292(1):38-53. DML6A8X RU https://pubmed.ncbi.nlm.nih.gov/10604930 DM80P4U DI DM80P4U DM80P4U DN S-234462 DM80P4U MI TTY6EWA DM80P4U MN Neuropeptide Y receptor type 5 (NPY5R) DM80P4U MT DTT DM80P4U MA Antagonist DM80P4U RN Clinical pipeline report, company report or official report of Shionogi (2011). DM80P4U RU http://www.shionogi.co.jp/index_e.html DM6SON1 DI DM6SON1 DM6SON1 DN S-23906-1 DM6SON1 MI TTUTN1I DM6SON1 MN Human Deoxyribonucleic acid (hDNA) DM6SON1 MT DTT DM6SON1 MA Binder DM6SON1 RN Induction of cyclin E and inhibition of DNA synthesis by the novel acronycine derivative S23906-1 precede the irreversible arrest of tumor cells in S phase leading to apoptosis. Mol Pharmacol. 2001 Dec;60(6):1383-91. DM6SON1 RU https://pubmed.ncbi.nlm.nih.gov/11723246 DM1R8Z7 DI DM1R8Z7 DM1R8Z7 DN S-33138 DM1R8Z7 MI TT4C8EA DM1R8Z7 MN Dopamine D3 receptor (D3R) DM1R8Z7 MT DTT DM1R8Z7 MA Antagonist DM1R8Z7 RN The dopamine D3 receptor antagonist, S33138, counters cognitive impairment in a range of rodent and primate procedures. Int J Neuropsychopharmacol. 2010 Sep;13(8):1035-51. DM1R8Z7 RU https://pubmed.ncbi.nlm.nih.gov/20663270 DMZYRI3 DI DMZYRI3 DMZYRI3 DN S-3536 DMZYRI3 MI TT1GHVO DMZYRI3 MN Matrix metalloproteinase (MMP) DMZYRI3 MT DTT DMZYRI3 MA Inhibitor DMZYRI3 RN CIINE Reflects Collagenase-Specific CII Breakdown in Cartilage Explant and Whole Body of Canine. Biomark Insights. 2013; 8: 77-83. DMZYRI3 RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3694827/ DMCEOAJ DI DMCEOAJ DMCEOAJ DN Sabcomeline DMCEOAJ MI TTZ9SOR DMCEOAJ MN Muscarinic acetylcholine receptor M1 (CHRM1) DMCEOAJ MT DTT DMCEOAJ MA Agonist DMCEOAJ RN Pharmacological comparison of muscarinic ligands: historical versus more recent muscarinic M1-preferring receptor agonists. Eur J Pharmacol. 2009 Mar 1;605(1-3):53-6. DMCEOAJ RU https://pubmed.ncbi.nlm.nih.gov/19168056 DMIZ7Q4 DI DMIZ7Q4 DMIZ7Q4 DN SAR101099 DMIZ7Q4 MI TTW5UDX DMIZ7Q4 MN Urotensin II receptor (UTS2R) DMIZ7Q4 MT DTT DMIZ7Q4 MA Antagonist DMIZ7Q4 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 365). DMIZ7Q4 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=365 DM7OR48 DI DM7OR48 DM7OR48 DN SAR-152954 DM7OR48 MI TT9JNIC DM7OR48 MN Histamine H3 receptor (H3R) DM7OR48 MT DTT DM7OR48 MA Antagonist DM7OR48 RN Clinical pipeline report, company report or official report of Sanofi. DM7OR48 RU https://ncats.nih.gov/files/SAR152954.pdf DMNH8XU DI DMNH8XU DMNH8XU DN SB 235699 DMNH8XU MI TTYT93M DMNH8XU MN MAP kinase p38 (MAPK12) DMNH8XU MT DTT DMNH8XU MA Inhibitor DMNH8XU RN Synthesis and structure-activity relationship of aminobenzophenones. A novel class of p38 MAP kinase inhibitors with high antiinflammatory activity. J Med Chem. 2003 Dec 18;46(26):5651-62. DMNH8XU RU https://pubmed.ncbi.nlm.nih.gov/14667219 DMNH8XU DI DMNH8XU DMNH8XU DN SB 235699 DMNH8XU MI TTQBR95 DMNH8XU MN Stress-activated protein kinase 2a (p38 alpha) DMNH8XU MT DTT DMNH8XU MA Inhibitor DMNH8XU RN Pharmacological inhibitors of MAPK pathways. Trends Pharmacol Sci. 2002 Jan;23(1):40-5. DMNH8XU RU https://pubmed.ncbi.nlm.nih.gov/11804650 DMNH8XU DI DMNH8XU DMNH8XU DN SB 235699 DMNH8XU MI TT73U6C DMNH8XU MN Stress-activated protein kinase 2b (p38 beta) DMNH8XU MT DTT DMNH8XU MA Inhibitor DMNH8XU RN Pharmacological inhibitors of MAPK pathways. Trends Pharmacol Sci. 2002 Jan;23(1):40-5. DMNH8XU RU https://pubmed.ncbi.nlm.nih.gov/11804650 DM2C0LN DI DM2C0LN DM2C0LN DN SB 249417 DM2C0LN MI TTFEZ5Q DM2C0LN MN Coagulation factor IX (F9) DM2C0LN MT DTT DM2C0LN RN Pharmacokinetic and pharmacodynamic modeling of humanized anti-factor IX antibody (SB 249417) in humans. Clin Pharmacol Ther. 2002 Apr;71(4):235-45. DM2C0LN RU https://pubmed.ncbi.nlm.nih.gov/11956506 DMGHDTB DI DMGHDTB DMGHDTB DN SB 418790 DMGHDTB MI TTMXGCW DMGHDTB MN Adrenergic receptor beta-3 (ADRB3) DMGHDTB MT DTT DMGHDTB MA Agonist DMGHDTB RN News and Analysis. Nature Reviews Drug Discovery 1, 257-258 (April 2002). DMGHDTB RU http://www.nature.com/nrd/journal/v1/n4/fig_tab/nrd781_T1.html DMX7PNY DI DMX7PNY DMX7PNY DN SB-234551 DMX7PNY MI TTKRD0G DMX7PNY MN Endothelin A receptor (EDNRA) DMX7PNY MT DTT DMX7PNY MA Antagonist DMX7PNY RN Effects of the novel selective endothelin ET(A) receptor antagonist, SB 234551, on the cardiovascular responses to endotoxaemia in conscious rats. Br J Pharmacol. 2001 Aug;133(8):1371-7. DMX7PNY RU https://pubmed.ncbi.nlm.nih.gov/11498524 DMKSFL0 DI DMKSFL0 DMKSFL0 DN SB-242235 DMKSFL0 MI TT9AZWY DMKSFL0 MN HSPB1 messenger RNA (HSPB1 mRNA) DMKSFL0 MT DTT DMKSFL0 MA Inhibitor DMKSFL0 RN Biphenyl amide p38 kinase inhibitors 4: DFG-in and DFG-out binding modes. Bioorg Med Chem Lett. 2008 Aug 1;18(15):4433-7. DMKSFL0 RU https://pubmed.ncbi.nlm.nih.gov/18602262 DMKSFL0 DI DMKSFL0 DMKSFL0 DN SB-242235 DMKSFL0 MI TTQBR95 DMKSFL0 MN Stress-activated protein kinase 2a (p38 alpha) DMKSFL0 MT DTT DMKSFL0 MA Inhibitor DMKSFL0 RN Biphenyl amide p38 kinase inhibitors 4: DFG-in and DFG-out binding modes. Bioorg Med Chem Lett. 2008 Aug 1;18(15):4433-7. DMKSFL0 RU https://pubmed.ncbi.nlm.nih.gov/18602262 DMOVLDT DI DMOVLDT DMOVLDT DN SB-247853 DMOVLDT MI TTWJBZ5 DMOVLDT MN 5-HT 2C receptor (HTR2C) DMOVLDT MT DTT DMOVLDT MA Agonist DMOVLDT RN Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800016366) DMOVLDT RU http://adisinsight.springer.com/drugs/800016366 DMIBFAV DI DMIBFAV DMIBFAV DN SB-267268 DMIBFAV MI TT69TQN DMIBFAV MN Integrin alpha-V/beta-3 (ITGAV/B3) DMIBFAV MT DTT DMIBFAV MA Modulator DMIBFAV RN SB-267268, a nonpeptidic antagonist of alpha(v)beta3 and alpha(v)beta5 integrins, reduces angiogenesis and VEGF expression in a mouse model of retinopathy of prematurity. Invest Ophthalmol Vis Sci. 2006 Apr;47(4):1600-5. DMIBFAV RU https://pubmed.ncbi.nlm.nih.gov/16565398 DMIBFAV DI DMIBFAV DMIBFAV DN SB-267268 DMIBFAV MI TTPRDH7 DMIBFAV MN Integrin alpha-V/beta-5 (ITGAV/B5) DMIBFAV MT DTT DMIBFAV MA Modulator DMIBFAV RN SB-267268, a nonpeptidic antagonist of alpha(v)beta3 and alpha(v)beta5 integrins, reduces angiogenesis and VEGF expression in a mouse model of retinopathy of prematurity. Invest Ophthalmol Vis Sci. 2006 Apr;47(4):1600-5. DMIBFAV RU https://pubmed.ncbi.nlm.nih.gov/16565398 DMV7M1H DI DMV7M1H DMV7M1H DN SB-273005 DMV7M1H MI TT69TQN DMV7M1H MN Integrin alpha-V/beta-3 (ITGAV/B3) DMV7M1H MT DTT DMV7M1H MA Modulator DMV7M1H RN Disease-modifying activity of SB 273005, an orally active, nonpeptide alphavbeta3 (vitronectin receptor) antagonist, in rat adjuvant-induced arthri... Arthritis Rheum. 2001 Jan;44(1):128-37. DMV7M1H RU https://www.ncbi.nlm.nih.gov/pubmed/11212150 DMYTAJW DI DMYTAJW DMYTAJW DN SB-281832 DMYTAJW MI TTWELHI DMYTAJW MN Stress-activated protein kinase (p38) DMYTAJW MT DTT DMYTAJW MA Inhibitor DMYTAJW RN p38 MAPK inhibitors ameliorate target organ damage in hypertension: Part 1. p38 MAPK-dependent endothelial dysfunction and hypertension. J Pharmacol Exp Ther. 2003 Dec;307(3):932-8. DMYTAJW RU https://pubmed.ncbi.nlm.nih.gov/14561851 DM57HZW DI DM57HZW DM57HZW DN SB-332235 DM57HZW MI TT30C9G DM57HZW MN C-X-C chemokine receptor type 2 (CXCR2) DM57HZW MT DTT DM57HZW MA Antagonist DM57HZW RN Emerging drugs for the treatment of chronic obstructive pulmonary disease. Expert Opin Emerg Drugs. 2006 May;11(2):275-91. DM57HZW RU https://pubmed.ncbi.nlm.nih.gov/16634702 DM92BXN DI DM92BXN DM92BXN DN SB-435495 DM92BXN MI TT9V5JH DM92BXN MN Phospholipase A2 (PLA2G1B) DM92BXN MT DTT DM92BXN MA Inhibitor DM92BXN RN The effect of lipoprotein-associated phospholipase A2 deficiency on pulmonary allergic responses in Aspergillus fumigatus sensitized mice. Respir Res. 2012 Nov 12;13:100. DM92BXN RU https://pubmed.ncbi.nlm.nih.gov/23140447 DMFC19E DI DMFC19E DMFC19E DN SC-52012 DMFC19E MI TT38RM1 DMFC19E MN Glycoprotein IIb/IIIa receptor (GPIIb/IIIa) DMFC19E MT DTT DMFC19E MA Modulator DMFC19E RN Characterization of Binding of an RGD Mimetic, [(3)H]-SC-52012, to Platelet GPIIb/IIIa. Platelets. 1995;6(5):288-95. DMFC19E RU https://pubmed.ncbi.nlm.nih.gov/21043715 DMIVRWS DI DMIVRWS DMIVRWS DN SC-57666 DMIVRWS MI TTVKILB DMIVRWS MN Prostaglandin G/H synthase 2 (COX-2) DMIVRWS MT DTT DMIVRWS MA Inhibitor DMIVRWS RN New cyclooxygenase-2/5-lipoxygenase inhibitors. 2. 7-tert-butyl-2,3-dihydro-3,3-dimethylbenzofuran derivatives as gastrointestinal safe antiinflamm... J Med Chem. 1998 Mar 26;41(7):1124-37. DMIVRWS RU https://pubmed.ncbi.nlm.nih.gov/9544212 DM92E0W DI DM92E0W DM92E0W DN SCH-211803 DM92E0W MI TTYEG6Q DM92E0W MN Muscarinic acetylcholine receptor M2 (CHRM2) DM92E0W MT DTT DM92E0W MA Inhibitor DM92E0W RN Improving the oral efficacy of CNS drug candidates: discovery of highly orally efficacious piperidinyl piperidine M2 muscarinic receptor antagonists. J Med Chem. 2002 Dec 5;45(25):5415-8. DM92E0W RU https://pubmed.ncbi.nlm.nih.gov/12459007 DMK40VO DI DMK40VO DMK40VO DN SCH-351591 DMK40VO MI TTZ97H5 DMK40VO MN Phosphodiesterase 4A (PDE4A) DMK40VO MT DTT DMK40VO MA Inhibitor DMK40VO RN Synthesis and profile of SCH351591, a novel PDE4 inhibitor. Bioorg Med Chem Lett. 2002 Jun 17;12(12):1621-3. DMK40VO RU https://pubmed.ncbi.nlm.nih.gov/12039576 DMK40VO DI DMK40VO DMK40VO DN SCH-351591 DMK40VO MI TTVIAT9 DMK40VO MN Phosphodiesterase 4B (PDE4B) DMK40VO MT DTT DMK40VO MA Inhibitor DMK40VO RN Synthesis and profile of SCH351591, a novel PDE4 inhibitor. Bioorg Med Chem Lett. 2002 Jun 17;12(12):1621-3. DMK40VO RU https://pubmed.ncbi.nlm.nih.gov/12039576 DMK40VO DI DMK40VO DMK40VO DN SCH-351591 DMK40VO MI TTSKMI8 DMK40VO MN Phosphodiesterase 4D (PDE4D) DMK40VO MT DTT DMK40VO MA Inhibitor DMK40VO RN Synthesis and profile of SCH351591, a novel PDE4 inhibitor. Bioorg Med Chem Lett. 2002 Jun 17;12(12):1621-3. DMK40VO RU https://pubmed.ncbi.nlm.nih.gov/12039576 DM8J9SF DI DM8J9SF DM8J9SF DN SCH-C DM8J9SF MI TT2CEJG DM8J9SF MN C-C chemokine receptor type 5 (CCR5) DM8J9SF MT DTT DM8J9SF MA Binder DM8J9SF RN Progress in targeting HIV-1 entry. Drug Discov Today. 2005 Aug 15;10(16):1085-94. DM8J9SF RU https://pubmed.ncbi.nlm.nih.gov/16182193 DM8J9SF DI DM8J9SF DM8J9SF DN SCH-C DM8J9SF MI TTJIH8Q DM8J9SF MN CCR5 messenger RNA (CCR5 mRNA) DM8J9SF MT DTT DM8J9SF MA Antagonist DM8J9SF RN Discovery and characterization of vicriviroc (SCH 417690), a CCR5 antagonist with potent activity against human immunodeficiency virus type 1. Antimicrob Agents Chemother. 2005 Dec;49(12):4911-9. DM8J9SF RU https://pubmed.ncbi.nlm.nih.gov/16304152 DM8BIV4 DI DM8BIV4 DM8BIV4 DN SDZ-210-086 DM8BIV4 MI TTZ9SOR DM8BIV4 MN Muscarinic acetylcholine receptor M1 (CHRM1) DM8BIV4 MT DTT DM8BIV4 MA Agonist DM8BIV4 RN Influence of the cholinergic agonist SDZ 210-086 on sleep in healthy subjects. Neuropsychopharmacology. 1993 Nov;9(3):225-32. DM8BIV4 RU https://pubmed.ncbi.nlm.nih.gov/8280346 DMU3TQJ DI DMU3TQJ DMU3TQJ DN SDZ-62-434 DMU3TQJ MI TTQL5VC DMU3TQJ MN Platelet-activating factor receptor (PTAFR) DMU3TQJ MT DTT DMU3TQJ MA Antagonist DMU3TQJ RN In vitro antitumour activity of the novel imidazoisoquinoline SDZ 62-434. Br J Cancer. 1993 May;67(5):989-95. DMU3TQJ RU https://pubmed.ncbi.nlm.nih.gov/8388233 DM70MJQ DI DM70MJQ DM70MJQ DN SDZ-CPI-975 DM70MJQ MI TTDL0NY DM70MJQ MN Carnitine O-palmitoyltransferase I (CPT1B) DM70MJQ MT DTT DM70MJQ MA Inhibitor DM70MJQ RN Hypoglycemic effects of a novel fatty acid oxidation inhibitor in rats and monkeys. Am J Physiol. 1998 Feb;274(2 Pt 2):R524-8. DM70MJQ RU https://pubmed.ncbi.nlm.nih.gov/9486313 DM1C0K4 DI DM1C0K4 DM1C0K4 DN SDZ-GLC-756 DM1C0K4 MI TTZFYLI DM1C0K4 MN Dopamine D1 receptor (D1R) DM1C0K4 MT DTT DM1C0K4 MA Modulator DM1C0K4 RN SDZ GLC 756, a novel octahydrobenzo[g]quinoline derivative exerts opposing effects on dopamine D1 and D2 receptors. J Neural Transm. 1996;103(1-2):17-30. DM1C0K4 RU https://pubmed.ncbi.nlm.nih.gov/9026371 DM1C0K4 DI DM1C0K4 DM1C0K4 DN SDZ-GLC-756 DM1C0K4 MI TTEX248 DM1C0K4 MN Dopamine D2 receptor (D2R) DM1C0K4 MT DTT DM1C0K4 MA Modulator DM1C0K4 RN SDZ GLC 756, a novel octahydrobenzo[g]quinoline derivative exerts opposing effects on dopamine D1 and D2 receptors. J Neural Transm. 1996;103(1-2):17-30. DM1C0K4 RU https://pubmed.ncbi.nlm.nih.gov/9026371 DM8C3G5 DI DM8C3G5 DM8C3G5 DN SDZ-NKT-343 DM8C3G5 MI TTZPO1L DM8C3G5 MN Substance-P receptor (TACR1) DM8C3G5 MT DTT DM8C3G5 MA Antagonist DM8C3G5 RN The effects of SDZ NKT 343, a potent NK1 receptor antagonist, on cutaneous responses of primate spinothalamic tract neurones sensitized by intradermal capsaicin injection. Exp Brain Res. 1998 Aug;121(3):355-8. DM8C3G5 RU https://pubmed.ncbi.nlm.nih.gov/9746141 DMTOH03 DI DMTOH03 DMTOH03 DN SDZ-NVI-085 DMTOH03 MI TTNGILX DMTOH03 MN Adrenergic receptor alpha-1A (ADRA1A) DMTOH03 MT DTT DMTOH03 MA Antagonist DMTOH03 RN SDZ NVI 085, an alpha 1A-adrenoceptor agonist with 5-HT2A receptor antagonist properties. Eur J Pharmacol. 1996 Feb 15;297(1-2):83-6. DMTOH03 RU https://pubmed.ncbi.nlm.nih.gov/8851170 DMZHOYM DI DMZHOYM DMZHOYM DN SDZ-PCO-400 DMZHOYM MI TT1VOHK DMZHOYM MN Potassium channel unspecific (KC) DMZHOYM MT DTT DMZHOYM MA Opener DMZHOYM RN Effects of a potassium channel opener (SDZ PCO 400) on guinea-pig and human pulmonary airways. Br J Pharmacol. 1992 Jun;106(2):423-9. DMZHOYM RU https://pubmed.ncbi.nlm.nih.gov/1382782 DMFLOT4 DI DMFLOT4 DMFLOT4 DN SDZ-WAG-994 DMFLOT4 MI TTK25J1 DMFLOT4 MN Adenosine A1 receptor (ADORA1) DMFLOT4 MT DTT DMFLOT4 MA Agonist DMFLOT4 RN The cardiac effects of a novel A1-adenosine receptor agonist in guinea pig isolated heart. J Pharmacol Exp Ther. 1994 Dec;271(3):1371-82. DMFLOT4 RU https://pubmed.ncbi.nlm.nih.gov/7996449 DMCQI25 DI DMCQI25 DMCQI25 DN SEP-226332 DMCQI25 MI TTNXLKE DMCQI25 MN 5-HT 3 receptor (5HT3R) DMCQI25 MT DTT DMCQI25 MA Antagonist DMCQI25 RN Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800020129) DMCQI25 RU http://adisinsight.springer.com/drugs/800020129 DMTGCSX DI DMTGCSX DMTGCSX DN SIM-916 DMTGCSX MI TTSXVID DMTGCSX MN Nuclear factor NF-kappa-B (NFKB) DMTGCSX MT DTT DMTGCSX MA Modulator DMTGCSX RN Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41. DMTGCSX RU https://www.ncbi.nlm.nih.gov/pubmed/15950434 DM1XEUV DI DM1XEUV DM1XEUV DN SKF-97574 DM1XEUV MI TTLOKXP DM1XEUV MN Gastric H(+)/K(+) ATPase (Proton pump) DM1XEUV MT DTT DM1XEUV MA Modulator DM1XEUV RN Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41. DM1XEUV RU https://www.ncbi.nlm.nih.gov/pubmed/15950434 DMP0DLW DI DMP0DLW DMP0DLW DN SL-25.1188 DMP0DLW MI TTGP7BY DMP0DLW MN Monoamine oxidase type B (MAO-B) DMP0DLW MT DTT DMP0DLW MA Inhibitor DMP0DLW RN [(11)C]SL25.1188, a new reversible radioligand to study the monoamine oxidase type B with PET: preclinical characterisation in nonhuman primate. Synapse. 2010 Jan;64(1):61-9. DMP0DLW RU https://pubmed.ncbi.nlm.nih.gov/19728365 DMFUTHB DI DMFUTHB DMFUTHB DN SL-90.0571 DMFUTHB MI TTRK8B9 DMFUTHB MN Sodium channel unspecific (NaC) DMFUTHB MT DTT DMFUTHB MA Modulator DMFUTHB RN WO patent application no. 19990639849, Novel sodium channel drugs and uses. DMFUTHB RU http://www.google.com/patents/WO1999063984A9?cl=en DM5TJIY DI DM5TJIY DM5TJIY DN SLV-311 DM5TJIY MI TT953CX DM5TJIY MN Motilin receptor (MLNR) DM5TJIY MT DTT DM5TJIY MA Modulator DM5TJIY RN Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800017412) DM5TJIY RU http://adisinsight.springer.com/drugs/800017412 DMJFWB7 DI DMJFWB7 DMJFWB7 DN SLV-313 DMJFWB7 MI TTSQIFT DMJFWB7 MN 5-HT 1A receptor (HTR1A) DMJFWB7 MT DTT DMJFWB7 MA Modulator DMJFWB7 RN Synthesis and dual D2 and 5-HT1A receptor binding affinities of 7-piperazinyl and 7-piperidinyl-3,4-dihydroquinazolin-2(1H)-ones. Med Chem. 2014;10(5):484-96. DMJFWB7 RU https://www.ncbi.nlm.nih.gov/pubmed/24024527 DMJFWB7 DI DMJFWB7 DMJFWB7 DN SLV-313 DMJFWB7 MI TTEX248 DMJFWB7 MN Dopamine D2 receptor (D2R) DMJFWB7 MT DTT DMJFWB7 MA Modulator DMJFWB7 RN Synthesis and dual D2 and 5-HT1A receptor binding affinities of 7-piperazinyl and 7-piperidinyl-3,4-dihydroquinazolin-2(1H)-ones. Med Chem. 2014;10(5):484-96. DMJFWB7 RU https://www.ncbi.nlm.nih.gov/pubmed/24024527 DMHRYX6 DI DMHRYX6 DMHRYX6 DN SLV-323 DMHRYX6 MI TTZPO1L DMHRYX6 MN Substance-P receptor (TACR1) DMHRYX6 MT DTT DMHRYX6 MA Modulator DMHRYX6 RN Emerging drugs for chemotherapy-induced emesis. Expert Opin Emerg Drugs. 2006 Mar;11(1):137-51. DMHRYX6 RU https://pubmed.ncbi.nlm.nih.gov/16503832 DM6CLX9 DI DM6CLX9 DM6CLX9 DN SM-6586 DM6CLX9 MI TT5HONZ DM6CLX9 MN Calcium channel unspecific (CaC) DM6CLX9 MT DTT DM6CLX9 MA Antagonist DM6CLX9 RN Calcium channel blocking properties of SM-6586 in rat heart and brain as assessed by radioligand binding assay. Jpn J Pharmacol. 1993 Oct;63(2):165-9. DM6CLX9 RU https://pubmed.ncbi.nlm.nih.gov/8283826 DMC49KO DI DMC49KO DMC49KO DN SMART anti-E/P selectin DMC49KO MI TTAU4D6 DMC49KO MN E-selectin (SELE) DMC49KO MT DTT DMC49KO MA Modulator DMC49KO RN HuEP5C7 as a humanized monoclonal anti-E/P-selectin neurovascular protective strategy in a blinded placebo-controlled trial of nonhuman primate stroke. Circ Res. 2002 Nov 15;91(10):907-14. DMC49KO RU https://pubmed.ncbi.nlm.nih.gov/12433835 DMC49KO DI DMC49KO DMC49KO DN SMART anti-E/P selectin DMC49KO MI TTE5VG0 DMC49KO MN P-selectin (SELP) DMC49KO MT DTT DMC49KO MA Modulator DMC49KO RN HuEP5C7 as a humanized monoclonal anti-E/P-selectin neurovascular protective strategy in a blinded placebo-controlled trial of nonhuman primate stroke. Circ Res. 2002 Nov 15;91(10):907-14. DMC49KO RU https://pubmed.ncbi.nlm.nih.gov/12433835 DMQSGOD DI DMQSGOD DMQSGOD DN SMP-028 DMQSGOD MI TTTWGIX DMQSGOD MN Leukotriene receptor (LTR) DMQSGOD MT DTT DMQSGOD MA Modulator DMQSGOD RN Effect of SMP-028 on steroidogenesis in rats; mechanism of toxicological events on endocrine organs of rats. Toxicol In Vitro. 2014 Apr;28(3):397-402. DMQSGOD RU https://pubmed.ncbi.nlm.nih.gov/24362046 DMKGL2I DI DMKGL2I DMKGL2I DN SPI-256 DMKGL2I MI TT5FNQT DMKGL2I MN Human immunodeficiency virus Protease (HIV PR) DMKGL2I MT DTT DMKGL2I MA Inhibitor DMKGL2I RN Current and Novel Inhibitors of HIV Protease. Viruses. 2009 December; 1(3): 1209-1239. DMKGL2I RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3185513/ DMWQKEN DI DMWQKEN DMWQKEN DN SPP-1148 DMWQKEN MI TTB2MXP DMWQKEN MN Angiotensinogenase renin (REN) DMWQKEN MT DTT DMWQKEN MA Inhibitor DMWQKEN RN New Developments in the Pharmacological Treatment of Hypertension: Dead-End or a Glimmer at the Horizon . Curr Hypertens Rep. 2015; 17(6): 42. DMWQKEN RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4412646/ DMKEHGT DI DMKEHGT DMKEHGT DN SPP-676 DMKEHGT MI TTB2MXP DMKEHGT MN Angiotensinogenase renin (REN) DMKEHGT MT DTT DMKEHGT MA Inhibitor DMKEHGT RN New Developments in the Pharmacological Treatment of Hypertension: Dead-End or a Glimmer at the Horizon . Curr Hypertens Rep. 2015; 17(6): 42. DMKEHGT RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4412646/ DMK4XT8 DI DMK4XT8 DMK4XT8 DN SR 144190 DMK4XT8 MI TTYO0A3 DMK4XT8 MN Substance-K receptor (TACR2) DMK4XT8 MT DTT DMK4XT8 MA Antagonist DMK4XT8 RN Pharmacologic evaluation of neurokinin-2 receptor antagonists in the guinea pig respiratory tract. Am J Vet Res. 2004 Jul;65(7):984-91. DMK4XT8 RU https://pubmed.ncbi.nlm.nih.gov/15281659 DML7KCO DI DML7KCO DML7KCO DN SR-146131 DML7KCO MI TTCG0AL DML7KCO MN Cholecystokinin receptor type A (CCKAR) DML7KCO MT DTT DML7KCO MA Agonist DML7KCO RN SR146131: a new potent, orally active, and selective nonpeptide cholecystokinin subtype 1 receptor agonist. I. In vitro studies. J Pharmacol Exp Ther. 1999 May;289(2):742-51. DML7KCO RU https://pubmed.ncbi.nlm.nih.gov/10215648 DM6X9M8 DI DM6X9M8 DM6X9M8 DN SR-271425 DM6X9M8 MI TTUTN1I DM6X9M8 MN Human Deoxyribonucleic acid (hDNA) DM6X9M8 MT DTT DM6X9M8 MA Binder DM6X9M8 RN A phase I dose-escalation study of SR271425, an intravenously dosed thioxanthone analog, administered weekly in patients with refractory solid tumors. Am J Clin Oncol. 2009 Feb;32(1):9-14. DM6X9M8 RU https://pubmed.ncbi.nlm.nih.gov/19194116 DM471IG DI DM471IG DM471IG DN SR-33805 DM471IG MI TT5HONZ DM471IG MN Calcium channel unspecific (CaC) DM471IG MT DTT DM471IG MA Modulator DM471IG RN Effects of a new class of calcium antagonists, SR33557 (fantofarone) and SR33805, on neuronal voltage-activated Ca++ channels. J Pharmacol Exp Ther. 1994 Dec;271(3):1348-52. DM471IG RU https://pubmed.ncbi.nlm.nih.gov/7996445 DMAICVN DI DMAICVN DMAICVN DN SR-47063 DMAICVN MI TT1VOHK DMAICVN MN Potassium channel unspecific (KC) DMAICVN MT DTT DMAICVN MA Opener DMAICVN RN Vasorelaxant effects of the potassium channel opener SR 47063 on the isolated human saphenous vein and rat aorta. Braz J Med Biol Res. 2000 Aug;33(8):961-6. DMAICVN RU https://pubmed.ncbi.nlm.nih.gov/10920439 DM3O4ST DI DM3O4ST DM3O4ST DN SS1(dsFv)-PE38 DM3O4ST MI TT4RXME DM3O4ST MN Mesothelin (MSLN) DM3O4ST MT DTT DM3O4ST RN Mesothelin targeted cancer immunotherapy. Eur J Cancer. 2008 Jan;44(1):46-53. DM3O4ST RU https://pubmed.ncbi.nlm.nih.gov/17945478 DMSOBW2 DI DMSOBW2 DMSOBW2 DN SSR-125180 DMSOBW2 MI TTCG0AL DMSOBW2 MN Cholecystokinin receptor type A (CCKAR) DMSOBW2 MT DTT DMSOBW2 MA Agonist DMSOBW2 RN US patent application no. 8,748,419, Antagonists. DMSOBW2 RU http://www.google.com.ar/Patents/US8748419 DMR9JA8 DI DMR9JA8 DMR9JA8 DN SSR-146977 DMR9JA8 MI TTBPGLU DMR9JA8 MN Neuromedin-K receptor (TACR3) DMR9JA8 MT DTT DMR9JA8 MA Antagonist DMR9JA8 RN Biochemical and pharmacological activities of SSR 146977, a new potent nonpeptide tachykinin NK3 receptor antagonist. Can J Physiol Pharmacol. 2002 May;80(5):482-8. DMR9JA8 RU https://pubmed.ncbi.nlm.nih.gov/12056557 DMI3K2D DI DMI3K2D DMI3K2D DN SSR-162369 DMI3K2D MI TTDIGC1 DMI3K2D MN Dipeptidyl peptidase 4 (DPP-4) DMI3K2D MT DTT DMI3K2D MA Inhibitor DMI3K2D RN Emerging drug candidates of dipeptidyl peptidase IV (DPP IV) inhibitor class for the treatment of Type 2 Diabetes. Curr Drug Targets. 2009 Jan;10(1):71-87. DMI3K2D RU https://pubmed.ncbi.nlm.nih.gov/19149538 DMBCQFH DI DMBCQFH DMBCQFH DN SUN-8399 DMBCQFH MI TTSQIFT DMBCQFH MN 5-HT 1A receptor (HTR1A) DMBCQFH MT DTT DMBCQFH MA Agonist DMBCQFH RN Effects of SUN 8399, a potent and selective 5-HT1A agonist, on conflict behavior and ambulatory activity in mice: comparison with those of buspirone, tandospirone and diazepam. Jpn J Pharmacol. 1994 Apr;64(4):273-80. DMBCQFH RU https://pubmed.ncbi.nlm.nih.gov/8057528 DM6BO7R DI DM6BO7R DM6BO7R DN SUN-9221 DM6BO7R MI TTYSN63 DM6BO7R MN 5-HT 2 receptor (5HT2R) DM6BO7R MT DTT DM6BO7R MA Modulator DM6BO7R RN Synthesis and pharmacological evaluation of pyrroloazepine derivatives as potent antihypertensive agents with antiplatelet aggregation activity. Chem Pharm Bull (Tokyo). 1999 Feb;47(2):246-56. DM6BO7R RU https://pubmed.ncbi.nlm.nih.gov/10071857 DM6BO7R DI DM6BO7R DM6BO7R DN SUN-9221 DM6BO7R MI TT34BHT DM6BO7R MN Adrenergic receptor alpha-1D (ADRA1D) DM6BO7R MT DTT DM6BO7R MA Modulator DM6BO7R RN Synthesis and pharmacological evaluation of pyrroloazepine derivatives as potent antihypertensive agents with antiplatelet aggregation activity. Chem Pharm Bull (Tokyo). 1999 Feb;47(2):246-56. DM6BO7R RU https://pubmed.ncbi.nlm.nih.gov/10071857 DM1Z42H DI DM1Z42H DM1Z42H DN SURADISTA DM1Z42H MI TTBID49 DM1Z42H MN C-X-C chemokine receptor type 4 (CXCR4) DM1Z42H MT DTT DM1Z42H MA Modulator DM1Z42H RN Suradista NSC 651016 inhibits the angiogenic activity of CXCL12-stromal cell-derived factor 1alpha. Clin Cancer Res. 2002 Dec;8(12):3955-60. DM1Z42H RU https://pubmed.ncbi.nlm.nih.gov/12473612 DMY3FES DI DMY3FES DMY3FES DN SW-33377 DMY3FES MI TTUTN1I DMY3FES MN Human Deoxyribonucleic acid (hDNA) DMY3FES MT DTT DMY3FES MA Binder DMY3FES RN Effects of SW 33377, SW 68210 and SW 71425 thioxanthones on in vitro colony formation of freshly explanted human tumor cells. Invest New Drugs. 1998-1999;16(3):221-5. DMY3FES RU https://pubmed.ncbi.nlm.nih.gov/10360601 DMSPBJ9 DI DMSPBJ9 DMSPBJ9 DN Symakalim DMSPBJ9 MI TT1VOHK DMSPBJ9 MN Potassium channel unspecific (KC) DMSPBJ9 MT DTT DMSPBJ9 MA Agonist DMSPBJ9 RN Synthesis and antihypertensive activity of 4-(diazabicyclo[4.1.0]-heptenyloxy)benzopyran derivatives and their analogues. Chem Pharm Bull (Tokyo). 1998 Apr;46(4):602-9. DMSPBJ9 RU https://pubmed.ncbi.nlm.nih.gov/9579035 DM4JPLM DI DM4JPLM DM4JPLM DN SYN-114 DM4JPLM MI TTJS8PY DM4JPLM MN 5-HT 6 receptor (HTR6) DM4JPLM MT DTT DM4JPLM MA Antagonist DM4JPLM RN Lewy bodies. Proc Natl Acad Sci U S A. 2006 February 7; 103(6): 1661-1668. DM4JPLM RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1413649/ DML4M5K DI DML4M5K DML4M5K DN T-0632 DML4M5K MI TTCG0AL DML4M5K MN Cholecystokinin receptor type A (CCKAR) DML4M5K MT DTT DML4M5K MA Antagonist DML4M5K RN Effect of T-0632, a cholecystokininA receptor antagonist, on experimental acute pancreatitis. Jpn J Pharmacol. 1997 Feb;73(2):105-12. DML4M5K RU https://pubmed.ncbi.nlm.nih.gov/9074944 DMQVLZH DI DMQVLZH DMQVLZH DN T-62 DMQVLZH MI TTM2AOE DMQVLZH MN Adenosine A2a receptor (ADORA2A) DMQVLZH MT DTT DMQVLZH MA Antagonist DMQVLZH RN Emerging drugs in neuropathic pain. Expert Opin Emerg Drugs. 2007 Mar;12(1):113-26. DMQVLZH RU https://pubmed.ncbi.nlm.nih.gov/17355217 DMFES2K DI DMFES2K DMFES2K DN TA-5493 DMFES2K MI TTWELHI DMFES2K MN Stress-activated protein kinase (p38) DMFES2K MT DTT DMFES2K MA Inhibitor DMFES2K RN US patent application no. 2008,0269,123, Methods for treating polycystic kidney disease (pkd) or other cyst forming diseases. DMFES2K RU http://www.google.com/patents/US20080269123 DMI52NT DI DMI52NT DMI52NT DN TAFA-93 DMI52NT MI TTCJG29 DMI52NT MN Serine/threonine-protein kinase mTOR (mTOR) DMI52NT MT DTT DMI52NT MA Inhibitor DMI52NT RN EP patent application no. 2275103, Mtor inhibitors in the treatment of endocrine tumors. DMI52NT RU http://www.google.com/patents/EP2275103A2?cl=en DMN02XD DI DMN02XD DMN02XD DN TAK-029 DMN02XD MI TT38RM1 DMN02XD MN Glycoprotein IIb/IIIa receptor (GPIIb/IIIa) DMN02XD MT DTT DMN02XD MA Modulator DMN02XD RN Platelet protective effect of TAK-029, a novel glycoprotein IIb/IIIa antagonist: an in vitro study. Artif Organs. 1998 Apr;22(4):348-52. DMN02XD RU https://www.ncbi.nlm.nih.gov/pubmed/9555968 DMH16ND DI DMH16ND DMH16ND DN TAK-100 DMH16ND MI TTDIGC1 DMH16ND MN Dipeptidyl peptidase 4 (DPP-4) DMH16ND MT DTT DMH16ND MA Inhibitor DMH16ND RN Clinical pipeline report, company report or official report of Takeda (2009). DMH16ND RU http://www.takeda.com/pdf/usr/default/10_1_34992_2.pdf DMBE5OF DI DMBE5OF DMBE5OF DN TAK165 DMBE5OF MI TTGKNB4 DMBE5OF MN Epidermal growth factor receptor (EGFR) DMBE5OF MT DTT DMBE5OF MA Inhibitor DMBE5OF RN A comparison of physicochemical property profiles of marketed oral drugs and orally bioavailable anti-cancer protein kinase inhibitors in clinical development. Curr Top Med Chem. 2007;7(14):1408-22. DMBE5OF RU https://pubmed.ncbi.nlm.nih.gov/17692029 DMBE5OF DI DMBE5OF DMBE5OF DN TAK165 DMBE5OF MI TT6EO5L DMBE5OF MN Erbb2 tyrosine kinase receptor (HER2) DMBE5OF MT DTT DMBE5OF MA Inhibitor DMBE5OF RN A comparison of physicochemical property profiles of marketed oral drugs and orally bioavailable anti-cancer protein kinase inhibitors in clinical development. Curr Top Med Chem. 2007;7(14):1408-22. DMBE5OF RU https://pubmed.ncbi.nlm.nih.gov/17692029 DM25DB4 DI DM25DB4 DM25DB4 DN TAK-591 DM25DB4 MI TT8DBY3 DM25DB4 MN Angiotensin II receptor type-1 (AGTR1) DM25DB4 MT DTT DM25DB4 MA Antagonist DM25DB4 RN Clinical pipeline report, company report or official report of Takeda (2009). DM25DB4 RU http://www.takeda.com/pdf/usr/default/10_1_34992_2.pdf DM25DB4 DI DM25DB4 DM25DB4 DN TAK-591 DM25DB4 MI TTQVOEI DM25DB4 MN Angiotensin II receptor type-2 (AGTR2) DM25DB4 MT DTT DM25DB4 MA Antagonist DM25DB4 RN Clinical pipeline report, company report or official report of Takeda (2009). DM25DB4 RU http://www.takeda.com/pdf/usr/default/10_1_34992_2.pdf DMRD8HK DI DMRD8HK DMRD8HK DN TAK-683 DMRD8HK MI TT3KBZY DMRD8HK MN G-protein coupled receptor 54 (KISS1R) DMRD8HK MT DTT DMRD8HK MA Agonist DMRD8HK RN Clinical pipeline report, company report or official report of Takeda (2009). DMRD8HK RU http://www.takeda.com/pdf/usr/default/10_1_34992_2.pdf DMRD8HK DI DMRD8HK DMRD8HK DN TAK-683 DMRD8HK MI TTN53ZF DMRD8HK MN Leukotriene B4 receptor 1 (LTB4R) DMRD8HK MT DTT DMRD8HK MA Antagonist DMRD8HK RN A second leukotriene B(4) receptor, BLT2. A new therapeutic target in inflammation and immunological disorders. J Exp Med. 2000 Aug 7;192(3):421-32. DMRD8HK RU https://pubmed.ncbi.nlm.nih.gov/10934230 DMCFOSG DI DMCFOSG DMCFOSG DN TAK-810 DMCFOSG MI TT0ID4A DMCFOSG MN Leutinizing-hormone-releasing hormone (GNRH1) DMCFOSG MT DTT DMCFOSG MA Inhibitor DMCFOSG RN EP patent application no. 2018865, Combination comprising n-(3-methoxy-5-methylpyrazin-2-yl)-2-(4-[1,3,4-oxadiazol-2-yl]phenyl)pyridine-3-sulphonamide and an lhrh analogue and/or a bisphosphonate. DMCFOSG RU http://www.google.es/patents/EP2018865A2?hl=es&cl=en DM13YN0 DI DM13YN0 DM13YN0 DN TAK-937 DM13YN0 MI TT6OEDT DM13YN0 MN Cannabinoid receptor 1 (CB1) DM13YN0 MT DTT DM13YN0 MA Modulator DM13YN0 RN Cerebroprotective effects of TAK-937, a cannabinoid receptor agonist, on ischemic brain damage in middle cerebral artery occluded rats and non-human primates. Brain Res. 2012 Jan 9;1430:93-100. DM13YN0 RU https://pubmed.ncbi.nlm.nih.gov/22119394 DM13YN0 DI DM13YN0 DM13YN0 DN TAK-937 DM13YN0 MI TTMSFAW DM13YN0 MN Cannabinoid receptor 2 (CB2) DM13YN0 MT DTT DM13YN0 MA Modulator DM13YN0 RN Cerebroprotective effects of TAK-937, a cannabinoid receptor agonist, on ischemic brain damage in middle cerebral artery occluded rats and non-human primates. Brain Res. 2012 Jan 9;1430:93-100. DM13YN0 RU https://pubmed.ncbi.nlm.nih.gov/22119394 DM1ZYCA DI DM1ZYCA DM1ZYCA DN TALTOBULIN DM1ZYCA MI TTML2WA DM1ZYCA MN Tubulin (TUB) DM1ZYCA MT DTT DM1ZYCA MA Inhibitor DM1ZYCA RN Absolute configurations of tubulin inhibitors taltobulin (HTI-286) and HTI-042 characterized by X-ray diffraction analysis and NMR studies. Bioorg Med Chem Lett. 2010 Mar 1;20(5):1535-8. DM1ZYCA RU https://pubmed.ncbi.nlm.nih.gov/20137930 DM5PZ60 DI DM5PZ60 DM5PZ60 DN TAZOMELINE DM5PZ60 MI TTZ9SOR DM5PZ60 MN Muscarinic acetylcholine receptor M1 (CHRM1) DM5PZ60 MT DTT DM5PZ60 MA Agonist DM5PZ60 RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015 DM5PZ60 RU https://www.accessdata.fda.gov/scripts/cder/drugsatfda/ DMCA97F DI DMCA97F DMCA97F DN TD-2749 DMCA97F MI TT07C3Y DMCA97F MN 5-HT 4 receptor (HTR4) DMCA97F MT DTT DMCA97F MA Agonist DMCA97F RN A Hybrid Structural Approach to Analyze Ligand Binding by the Serotonin Type 4 Receptor (5-HT4). Mol Cell Proteomics. 2013 May; 12(5): 1259-1271. DMCA97F RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3650337/ DMDT5HZ DI DMDT5HZ DMDT5HZ DN Teloxantrone DMDT5HZ MI TT0IHXV DMDT5HZ MN DNA topoisomerase II (TOP2) DMDT5HZ MT DTT DMDT5HZ MA Modulator DMDT5HZ RN Topoisomerase II inhibition and cytotoxicity of the anthrapyrazoles DuP 937 and DuP 941 (Losoxantrone) in the National Cancer Institute preclinical... J Natl Cancer Inst. 1994 Aug 17;86(16):1239-44. DMDT5HZ RU https://www.ncbi.nlm.nih.gov/pubmed/8040892 DM9KYVQ DI DM9KYVQ DM9KYVQ DN TG-1024 DM9KYVQ MI TTF89GD DM9KYVQ MN Interleukin-2 (IL2) DM9KYVQ MT DTT DM9KYVQ MA Modulator DM9KYVQ RN Melanoma and Immunotherapy. Hematology/Oncology Clinics of North America Volume 23, Issue 3, June 2009, Pages 547-564. DM9KYVQ RU http://www.sciencedirect.com/science/article/pii/S0889858809000458 DMELNA8 DI DMELNA8 DMELNA8 DN TGN-1412 DMELNA8 MI TTQ13FT DMELNA8 MN T-cell-specific surface glycoprotein CD28 (CD28) DMELNA8 MT DTT DMELNA8 RN TGN1412: From Discovery to Disaster. J Young Pharm. 2010 Jul-Sep; 2(3): 332-336. DMELNA8 RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2964774/ DMTC4LP DI DMTC4LP DMTC4LP DN Tidembersat DMTC4LP MI TT6MSOK DMTC4LP MN 5-HT 1D receptor (HTR1D) DMTC4LP MT DTT DMTC4LP MA Antagonist DMTC4LP RN Sustained pain relief with dihydroergotamine in migraine is potentially due to persistent binding to 5-HT1B and 5-HT1D receptors. . The Journal of Headache and Pain 201314(Suppl 1):P75. DMTC4LP RU http://www.thejournalofheadacheandpain.com/content/pdf/1129-2377-14-S1-P75.pdf DMI0Q8Y DI DMI0Q8Y DMI0Q8Y DN TOP-53 DMI0Q8Y MI TT0IHXV DMI0Q8Y MN DNA topoisomerase II (TOP2) DMI0Q8Y MT DTT DMI0Q8Y MA Modulator DMI0Q8Y RN DNA topoisomerase II as the target for the anticancer drug TOP-53: mechanistic basis for drug action. Biochemistry. 2001 Jan 23;40(3):712-8. DMI0Q8Y RU https://pubmed.ncbi.nlm.nih.gov/11170388 DM6SUDC DI DM6SUDC DM6SUDC DN Totrombopag DM6SUDC MI TTIHYA4 DM6SUDC MN Thrombopoietin receptor (MPL) DM6SUDC MT DTT DM6SUDC MA Agonist DM6SUDC RN Clinical pipeline report, company report or official report of GlaxoSmithKline (2009). DM6SUDC RU http://www.gsk.com/investors/product_pipeline/docs/gsk-pipeline-feb09.pdf DMCV2KQ DI DMCV2KQ DMCV2KQ DN TP-9201 DMCV2KQ MI TT38RM1 DMCV2KQ MN Glycoprotein IIb/IIIa receptor (GPIIb/IIIa) DMCV2KQ MT DTT DMCV2KQ MA Modulator DMCV2KQ RN TP-9201, a glycoprotein IIb/IIIa platelet receptor antagonist, prevents rethrombosis after successful arterial thrombolysis in the dog. Stroke. 1997 Sep;28(9):1789-96. DMCV2KQ RU https://pubmed.ncbi.nlm.nih.gov/9303027 DMWD39E DI DMWD39E DMWD39E DN Tr-14035 DMWD39E MI TT6S84X DMWD39E MN Integrin alpha-4/beta-1 (ITGA4/B1) DMWD39E MT DTT DMWD39E MA Modulator DMWD39E RN Pharmacokinetics and metabolism of TR-14035, a novel antagonist of a4ss1/a4ss7 integrin mediated cell adhesion, in rat and dog. Xenobiotica. 2005 Apr;35(4):373-89. DMWD39E RU https://www.ncbi.nlm.nih.gov/pubmed/16019958 DMWD39E DI DMWD39E DMWD39E DN Tr-14035 DMWD39E MI TT7ZMI1 DMWD39E MN Integrin alpha-4/beta-7 (ITGA4/B7) DMWD39E MT DTT DMWD39E MA Modulator DMWD39E RN Pharmacokinetics and metabolism of TR-14035, a novel antagonist of a4ss1/a4ss7 integrin mediated cell adhesion, in rat and dog. Xenobiotica. 2005 Apr;35(4):373-89. DMWD39E RU https://www.ncbi.nlm.nih.gov/pubmed/16019958 DMWD39E DI DMWD39E DMWD39E DN Tr-14035 DMWD39E MI DTE2B1D DMWD39E MN Organic anion transporting polypeptide 1A2 (SLCO1A2) DMWD39E MT DTP DMWD39E MA Substrate DMWD39E RN Characterization of hepatobiliary transport systems of a novel alpha4beta1/alpha4beta7 dual antagonist, TR-14035. Pharm Res. 2006 Nov;23(11):2646-56. DMWD39E RU https://doi.org/10.1007/s11095-006-9102-6 DMWD39E DI DMWD39E DMWD39E DN Tr-14035 DMWD39E MI DT3D8F0 DMWD39E MN Organic anion transporting polypeptide 1B1 (SLCO1B1) DMWD39E MT DTP DMWD39E MA Substrate DMWD39E RN Cellular entry of thyroid hormones by organic anion transporting polypeptides. Best Pract Res Clin Endocrinol Metab. 2007 Jun;21(2):209-21. DMWD39E RU https://doi.org/10.1016/j.beem.2007.03.004 DMH5SA6 DI DMH5SA6 DMH5SA6 DN TR-14531 DMH5SA6 MI TTHIZP9 DMH5SA6 MN Integrin alpha-5 (ITGA5) DMH5SA6 MT DTT DMH5SA6 MA Antagonist DMH5SA6 RN US patent application no. US2010278784 (A1), Methods and compositions for treating skin conditions. DMH5SA6 RU http://worldwide.espacenet.com/publicationDetails/biblio?DB=worldwide.espacenet.com&II=0&ND=3&adjacent=true&locale=en_EP&FT=D&date=20101104&CC=US&NR=2010278784A1&KC=A1 DMZ5RA7 DI DMZ5RA7 DMZ5RA7 DN TRK-851 DMZ5RA7 MI TT27RFC DMZ5RA7 MN Opioid receptor delta (OPRD1) DMZ5RA7 MT DTT DMZ5RA7 MA Antagonist DMZ5RA7 RN Design and synthesis of a metabolically stable and potent antitussive agent, a novel delta opioid receptor antagonist, TRK-851. Bioorg Med Chem. 2008 Sep 1;16(17):7956-67. DMZ5RA7 RU https://pubmed.ncbi.nlm.nih.gov/18701308 DMSFV9T DI DMSFV9T DMSFV9T DN TRM-115 DMSFV9T MI TTQHJ1K DMSFV9T MN Histamine H2 receptor (H2R) DMSFV9T MT DTT DMSFV9T MA Antagonist DMSFV9T RN Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800002138) DMSFV9T RU http://adisinsight.springer.com/drugs/800002138 DMOHEYU DI DMOHEYU DMOHEYU DN TS-032 DMOHEYU MI TTXJ47W DMOHEYU MN Metabotropic glutamate receptor 2 (mGluR2) DMOHEYU MT DTT DMOHEYU MA Agonist DMOHEYU RN Metabotropic glutamate receptor subtype 2/3 (mGluR2/3); serotonin receptor (5-HT2A receptor). SciBX 1(6); doi:10.1038/scibx.2008.145. March 6 2008 DMOHEYU RU http://www.nature.com/scibx/journal/v1/n6/full/scibx.2008.145.html DMHJXL6 DI DMHJXL6 DMHJXL6 DN TT-235 DMHJXL6 MI TTSCIUP DMHJXL6 MN Oxytocin receptor (OTR) DMHJXL6 MT DTT DMHJXL6 MA Antagonist DMHJXL6 RN In vivo activity of the potent oxytocin antagonist on uterine activity in the rat. In Vivo. 2004 Nov-Dec;18(6):763-6. DMHJXL6 RU https://pubmed.ncbi.nlm.nih.gov/15646817 DMTVC3W DI DMTVC3W DMTVC3W DN U-103017 DMTVC3W MI TT5FNQT DMTVC3W MN Human immunodeficiency virus Protease (HIV PR) DMTVC3W MT DTT DMTVC3W MA Inhibitor DMTVC3W RN Structure-based design of sulfonamide-substituted non-peptidic HIV protease inhibitors. J Med Chem. 1995 Dec 22;38(26):4968-71. DMTVC3W RU https://pubmed.ncbi.nlm.nih.gov/8544171 DMC94D2 DI DMC94D2 DMC94D2 DN U-104067F DMC94D2 MI TTV0YFR DMC94D2 MN Lipid peroxidation (LPO) DMC94D2 MT DTT DMC94D2 MA Modulator DMC94D2 RN Two novel pyrrolopyrimidine lipid peroxidation inhibitors U-101033E and U-104067F protect facial motor neurons following neonatal axotomy. Exp Neurol. 1996 Oct;141(2):304-9. DMC94D2 RU https://pubmed.ncbi.nlm.nih.gov/8812165 DM2WOPX DI DM2WOPX DM2WOPX DN U-78875 DM2WOPX MI TT1MPAY DM2WOPX MN GABA(A) receptor alpha-1 (GABRA1) DM2WOPX MT DTT DM2WOPX MA Inhibitor DM2WOPX RN Piperazine imidazo[1,5-a]quinoxaline ureas as high-affinity GABAA ligands of dual functionality. J Med Chem. 1999 Apr 8;42(7):1123-44. DM2WOPX RU https://pubmed.ncbi.nlm.nih.gov/10197957 DM2WOPX DI DM2WOPX DM2WOPX DN U-78875 DM2WOPX MI TTZA1NY DM2WOPX MN GABA(A) receptor beta-2 (GABRB2) DM2WOPX MT DTT DM2WOPX MA Inhibitor DM2WOPX RN High-affinity alpha-aminobutyric acid A/benzodiazepine ligands: synthesis and structure-activity relationship studies of a new series of tetracycli... J Med Chem. 1996 Nov 8;39(23):4654-66. 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DM2WOPX RU https://pubmed.ncbi.nlm.nih.gov/10197957 DMMSWJ3 DI DMMSWJ3 DMMSWJ3 DN U-93385 DMMSWJ3 MI TTSQIFT DMMSWJ3 MN 5-HT 1A receptor (HTR1A) DMMSWJ3 MT DTT DMMSWJ3 MA Agonist DMMSWJ3 RN Tolerance development to the vagal-mediated bradycardia produced by 5-HT1A receptor agonists. J Pharmacol Exp Ther. 1994 Nov;271(2):776-81. DMMSWJ3 RU https://pubmed.ncbi.nlm.nih.gov/7965796 DML73BR DI DML73BR DML73BR DN U-96988 DML73BR MI TT5FNQT DML73BR MN Human immunodeficiency virus Protease (HIV PR) DML73BR MT DTT DML73BR MA Inhibitor DML73BR RN Structure-based design of HIV protease inhibitors: 4-hydroxycoumarins and 4-hydroxy-2-pyrones as non-peptidic inhibitors. J Med Chem. 1994 Sep 30;37(20):3200-4. 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DMXN9Z5 RU https://pubmed.ncbi.nlm.nih.gov/10710122 DMR2EUV DI DMR2EUV DMR2EUV DN V-102862 DMR2EUV MI TT84DRB DMR2EUV MN Voltage-gated sodium channel alpha Nav1.4 (SCN4A) DMR2EUV MT DTT DMR2EUV MA Inhibitor DMR2EUV RN 3-(4-phenoxyphenyl)pyrazoles: a novel class of sodium channel blockers. J Med Chem. 2004 Mar 11;47(6):1547-52. DMR2EUV RU https://pubmed.ncbi.nlm.nih.gov/14998340 DMR2EUV DI DMR2EUV DMR2EUV DN V-102862 DMR2EUV MI TT4G2JS DMR2EUV MN Voltage-gated sodium channel alpha Nav1.7 (SCN9A) DMR2EUV MT DTT DMR2EUV MA Inhibitor DMR2EUV RN Substituted biaryl oxazoles, imidazoles, and thiazoles as sodium channel blockers. Bioorg Med Chem Lett. 2010 Sep 15;20(18):5536-40. DMR2EUV RU https://pubmed.ncbi.nlm.nih.gov/20709552 DMLFMSY DI DMLFMSY DMLFMSY DN V85546 DMLFMSY MI TTXZ0KQ DMLFMSY MN Matrix metalloproteinase-12 (MMP-12) DMLFMSY MT DTT DMLFMSY MA Inhibitor DMLFMSY RN Clinical pipeline report, company report or official report of Vernalis. 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DMBQPA5 RU https://pubmed.ncbi.nlm.nih.gov/16503828 DMKRG0I DI DMKRG0I DMKRG0I DN VNA-932 DMKRG0I MI TTK8R02 DMKRG0I MN Vasopressin V2 receptor (V2R) DMKRG0I MT DTT DMKRG0I MA Agonist DMKRG0I RN Biased Agonist Pharmacochaperones of the AVP V2 Receptor May Treat Congenital Nephrogenic Diabetes Insipidus. J Am Soc Nephrol. 2009 October; 20(10): 2190-2203. DMKRG0I RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2754097/ DMATEL0 DI DMATEL0 DMATEL0 DN Vorsetuzumab mafodotin DMATEL0 MI TTNCIE0 DMATEL0 MN CD70 antigen (CD27-L) DMATEL0 MT DTT DMATEL0 RN National Cancer Institute Drug Dictionary (drug id 660730). DMATEL0 RU http://www.cancer.gov/publications/dictionaries/cancer-drug?cdrid=660730 DMXK8FQ DI DMXK8FQ DMXK8FQ DN VP004 DMXK8FQ MI TT27RFC DMXK8FQ MN Opioid receptor delta (OPRD1) DMXK8FQ MT DTT DMXK8FQ RN WO patent application no. 2007,0677,14, Treatment of sequelae of psychiatric disorders. 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DMFQWNI RU https://www.ncbi.nlm.nih.gov/pubmed/?term=20133892 DM3GD7V DI DM3GD7V DM3GD7V DN WAY-100289 DM3GD7V MI TTNXLKE DM3GD7V MN 5-HT 3 receptor (5HT3R) DM3GD7V MT DTT DM3GD7V MA Modulator DM3GD7V RN The selective 5-HT3 receptor antagonist, WAY100289, enhances spatial memory in rats with ibotenate lesions of the forebrain cholinergic projection system. Psychopharmacology (Berl). 1995 Feb;117(3):318-32. DM3GD7V RU https://pubmed.ncbi.nlm.nih.gov/7770608 DM8SVHI DI DM8SVHI DM8SVHI DN WAY-181187 DM8SVHI MI TTJS8PY DM8SVHI MN 5-HT 6 receptor (HTR6) DM8SVHI MT DTT DM8SVHI MA Modulator DM8SVHI RN Neuropharmacological profile of novel and selective 5-HT6 receptor agonists: WAY-181187 and WAY-208466.Neuropsychopharmacology.2008 May;33(6):1323-35. DM8SVHI RU https://www.ncbi.nlm.nih.gov/pubmed/17625499 DMSZJ5H DI DMSZJ5H DMSZJ5H DN Wetimicin DMSZJ5H MI TTOVFH2 DMSZJ5H MN Bacterial 30S ribosomal RNA (Bact 30S rRNA) DMSZJ5H MT DTT DMSZJ5H MA Inhibitor DMSZJ5H RN Cross susceptibility of ototoxicity about aminoglycoside antibiotics. Lin Chuang Er Bi Yan Hou Ke Za Zhi. 1997 Jan;11(1):9-10. DMSZJ5H RU https://pubmed.ncbi.nlm.nih.gov/9644172 DMHTG38 DI DMHTG38 DMHTG38 DN XL844 DMHTG38 MI TTTU902 DMHTG38 MN Checkpoint kinase-1 (CHK1) DMHTG38 MT DTT DMHTG38 MA Modulator DMHTG38 RN Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41. DMHTG38 RU https://www.ncbi.nlm.nih.gov/pubmed/15950434 DMHTG38 DI DMHTG38 DMHTG38 DN XL844 DMHTG38 MI TT9ABMF DMHTG38 MN Serine/threonine-protein kinase Chk2 (RAD53) DMHTG38 MT DTT DMHTG38 MA Modulator DMHTG38 RN Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41. DMHTG38 RU https://www.ncbi.nlm.nih.gov/pubmed/15950434 DMQKH07 DI DMQKH07 DMQKH07 DN XM-323 DMQKH07 MI TT5FNQT DMQKH07 MN Human immunodeficiency virus Protease (HIV PR) DMQKH07 MT DTT DMQKH07 MA Inhibitor DMQKH07 RN In vitro anti-human immunodeficiency virus (HIV) activity of XM323, a novel HIV protease inhibitor. Antimicrob Agents Chemother. 1993 Dec;37(12):2606-11. DMQKH07 RU https://pubmed.ncbi.nlm.nih.gov/8109924 DMCK210 DI DMCK210 DMCK210 DN XR-9051 DMCK210 MI TTO32GK DMCK210 MN P-glycoprotein (P-GP) DMCK210 MT DTT DMCK210 MA Inhibitor DMCK210 RN Communication between multiple drug binding sites on P-glycoprotein. Mol Pharmacol. 2000 Sep;58(3):624-32. DMCK210 RU https://pubmed.ncbi.nlm.nih.gov/10953057 DM3Y6M7 DI DM3Y6M7 DM3Y6M7 DN XTL-2125 DM3Y6M7 MI TT79JGK DM3Y6M7 MN Mycobacterium RNA polymerase (MycB RNAP) DM3Y6M7 MT DTT DM3Y6M7 MA Modulator DM3Y6M7 RN DOI: 10.1111/j.1365-2036.2009.03927.x DM3Y6M7 RU http://onlinelibrary.wiley.com/doi/10.1111/j.1365-2036.2009.03927.x/full DM0FSA9 DI DM0FSA9 DM0FSA9 DN YM-17E DM0FSA9 MI TTMF541 DM0FSA9 MN Liver carboxylesterase (CES1) DM0FSA9 MT DTT DM0FSA9 MA Modulator DM0FSA9 RN Pharmacological properties of YM17E, an acyl-CoA:cholesterol acyltransferase inhibitor, and diarrheal effect in beagle dogs. Jpn J Pharmacol. 1997 Jan;73(1):41-50. DM0FSA9 RU https://pubmed.ncbi.nlm.nih.gov/9032133 DMLD2R0 DI DMLD2R0 DMLD2R0 DN YM-750 DMLD2R0 MI TTMF541 DMLD2R0 MN Liver carboxylesterase (CES1) DMLD2R0 MT DTT DMLD2R0 MA Inhibitor DMLD2R0 RN Effects of an anti-oxidative ACAT inhibitor on apoptosis/necrosis and cholesterol accumulation under oxidative stress in THP-1 cell-derived foam ce... Life Sci. 2008 Jan 2;82(1-2):79-84. DMLD2R0 RU https://pubmed.ncbi.nlm.nih.gov/18037448 DMDJ2O5 DI DMDJ2O5 DMDJ2O5 DN YM-75466 DMDJ2O5 MI TTCIHJA DMDJ2O5 MN Coagulation factor Xa (F10) DMDJ2O5 MT DTT DMDJ2O5 MA Inhibitor DMDJ2O5 RN Semuloparin for the prevention of venous thromboembolic events in cancer patients. Drugs Today (Barc). 2012 Jul;48(7):451-7. DMDJ2O5 RU https://pubmed.ncbi.nlm.nih.gov/22844656 DMCDK6S DI DMCDK6S DMCDK6S DN YM-976 DMCDK6S MI TTZ97H5 DMCDK6S MN Phosphodiesterase 4A (PDE4A) DMCDK6S MT DTT DMCDK6S MA Inhibitor DMCDK6S RN Antiasthmatic effect of YM976, a novel PDE4 inhibitor, in guinea pigs. J Pharmacol Exp Ther. 2001 Apr;297(1):165-73. DMCDK6S RU https://pubmed.ncbi.nlm.nih.gov/11259541 DMCDK6S DI DMCDK6S DMCDK6S DN YM-976 DMCDK6S MI TTVIAT9 DMCDK6S MN Phosphodiesterase 4B (PDE4B) DMCDK6S MT DTT DMCDK6S MA Inhibitor DMCDK6S RN Therapeutic target database update 2012: a resource for facilitating target-oriented drug discovery. Nucleic Acids Res. 2012 Jan;40(Database issue):D1128-36. DMCDK6S RU https://pubmed.ncbi.nlm.nih.gov/21948793 DMCDK6S DI DMCDK6S DMCDK6S DN YM-976 DMCDK6S MI TTSKMI8 DMCDK6S MN Phosphodiesterase 4D (PDE4D) DMCDK6S MT DTT DMCDK6S MA Inhibitor DMCDK6S RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015 DMCDK6S RU https://www.accessdata.fda.gov/scripts/cder/drugsatfda/ DMA412G DI DMA412G DMA412G DN Z-300 DMA412G MI TTQHJ1K DMA412G MN Histamine H2 receptor (H2R) DMA412G MT DTT DMA412G MA Antagonist DMA412G RN Effects of a new histamine H2-receptor antagonist, Z-300, on gastric secretion and gastro-duodenal lesions in rats: comparison with roxatidine. Jpn J Pharmacol. 1992 Jul;59(3):275-89. DMA412G RU https://pubmed.ncbi.nlm.nih.gov/1359178 DMLO2QY DI DMLO2QY DMLO2QY DN Z-321 DMLO2QY MI TTNGKET DMLO2QY MN Prolyl endopeptidase (PREP) DMLO2QY MT DTT DMLO2QY MA Modulator DMLO2QY RN Z-321, a prolyl endopeptidase inhibitor, augments the potentiation of synaptic transmission in rat hippocampal slices. Behav Brain Res. 1997 Feb;83(1-2):213-6. DMLO2QY RU https://pubmed.ncbi.nlm.nih.gov/9062687 DM82V1D DI DM82V1D DM82V1D DN ZD-0892 DM82V1D MI TTPLTSQ DM82V1D MN Neutrophil elastase (NE) DM82V1D MT DTT DM82V1D MA Inhibitor DM82V1D RN Neutrophil elastase inhibitors as treatment for COPD. Expert Opin Investig Drugs. 2002 Jul;11(7):965-80. DM82V1D RU https://pubmed.ncbi.nlm.nih.gov/12084007 DMUDLFM DI DMUDLFM DMUDLFM DN ZD-1611 DMUDLFM MI TTKRD0G DMUDLFM MN Endothelin A receptor (EDNRA) DMUDLFM MT DTT DMUDLFM MA Antagonist DMUDLFM RN Pharmacological profile of ZD1611, a novel, orally active endothelin ETA receptor antagonist. J Pharmacol Exp Ther. 1999 Sep;290(3):1085-91. DMUDLFM RU https://pubmed.ncbi.nlm.nih.gov/10454481 DM7JUCI DI DM7JUCI DM7JUCI DN ZD-2767 DM7JUCI MI TTUTN1I DM7JUCI MN Human Deoxyribonucleic acid (hDNA) DM7JUCI MT DTT DM7JUCI MA Binder DM7JUCI RN Induction of apoptosis by the ADEPT agent ZD2767: comparison with the classical nitrogen mustard chlorambucil and a monofunctional ZD2767 analogue. Br J Cancer. 2001 September; 85(5): 764-771. DM7JUCI RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2364118/ DMQDNU1 DI DMQDNU1 DMQDNU1 DN ZD-4927 DMQDNU1 MI TTCIHJA DMQDNU1 MN Coagulation factor Xa (F10) DMQDNU1 MT DTT DMQDNU1 MA Inhibitor DMQDNU1 RN Semuloparin for the prevention of venous thromboembolic events in cancer patients. Drugs Today (Barc). 2012 Jul;48(7):451-7. DMQDNU1 RU https://pubmed.ncbi.nlm.nih.gov/22844656 DM1EB6H DI DM1EB6H DM1EB6H DN ZD-7349 DM1EB6H MI TTHIZP9 DM1EB6H MN Integrin alpha-5 (ITGA5) DM1EB6H MT DTT DM1EB6H MA Antagonist DM1EB6H RN Eosinophil adhesion to cholinergic nerves via ICAM-1 and VCAM-1 and associated eosinophil degranulation. Am J Physiol Lung Cell Mol Physiol. 2002 Jun;282(6):L1279-88. DM1EB6H RU https://pubmed.ncbi.nlm.nih.gov/12003784 DMJ9R4A DI DMJ9R4A DMJ9R4A DN ZK 304709 DMJ9R4A MI TTH6V3D DMJ9R4A MN Cyclin-dependent kinase 1 (CDK1) DMJ9R4A MT DTT DMJ9R4A MA Inhibitor DMJ9R4A RN Cell cycle kinases as therapeutic targets for cancer. Nat Rev Drug Discov. 2009 Jul;8(7):547-66. DMJ9R4A RU https://pubmed.ncbi.nlm.nih.gov/19568282 DMJ9R4A DI DMJ9R4A DMJ9R4A DN ZK 304709 DMJ9R4A MI TT7HF4W DMJ9R4A MN Cyclin-dependent kinase 2 (CDK2) DMJ9R4A MT DTT DMJ9R4A MA Inhibitor DMJ9R4A RN Cell cycle kinases as therapeutic targets for cancer. Nat Rev Drug Discov. 2009 Jul;8(7):547-66. DMJ9R4A RU https://pubmed.ncbi.nlm.nih.gov/19568282 DMJ9R4A DI DMJ9R4A DMJ9R4A DN ZK 304709 DMJ9R4A MI TT0PG8F DMJ9R4A MN Cyclin-dependent kinase 4 (CDK4) DMJ9R4A MT DTT DMJ9R4A MA Inhibitor DMJ9R4A RN Cell cycle kinases as therapeutic targets for cancer. Nat Rev Drug Discov. 2009 Jul;8(7):547-66. DMJ9R4A RU https://pubmed.ncbi.nlm.nih.gov/19568282 DMJ9R4A DI DMJ9R4A DMJ9R4A DN ZK 304709 DMJ9R4A MI TTQYF7G DMJ9R4A MN Cyclin-dependent kinase 7 (CDK7) DMJ9R4A MT DTT DMJ9R4A MA Inhibitor DMJ9R4A RN Cell cycle kinases as therapeutic targets for cancer. Nat Rev Drug Discov. 2009 Jul;8(7):547-66. DMJ9R4A RU https://pubmed.ncbi.nlm.nih.gov/19568282 DMJ9R4A DI DMJ9R4A DMJ9R4A DN ZK 304709 DMJ9R4A MI TT1LVF2 DMJ9R4A MN Cyclin-dependent kinase 9 (CDK9) DMJ9R4A MT DTT DMJ9R4A MA Inhibitor DMJ9R4A RN Cell cycle kinases as therapeutic targets for cancer. Nat Rev Drug Discov. 2009 Jul;8(7):547-66. DMJ9R4A RU https://pubmed.ncbi.nlm.nih.gov/19568282 DMHXVN1 DI DMHXVN1 DMHXVN1 DN DFD-11 DMHXVN1 MI TT1GHVO DMHXVN1 MN Matrix metalloproteinase (MMP) DMHXVN1 MT DTT DMHXVN1 MA Inhibitor DMHXVN1 RN Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) DMHXVN1 RU http://phrma-docs.phrma.org/files/dmfile/MID_Skin_Diseases_2018_9_FINAL.pdf DMCA7LN DI DMCA7LN DMCA7LN DN Oxycodone hydrochloride DMCA7LN MI DECB0K3 DMCA7LN MN Cytochrome P450 2D6 (CYP2D6) DMCA7LN MT DME DMCA7LN MA Metabolism DMCA7LN RN Metabolism and disposition of prescription opioids: a review. Forensic Sci Rev. 2015 Jul;27(2):115-45. DMCA7LN RU https://www.ncbi.nlm.nih.gov/pubmed/?term=26227254 DMCA7LN DI DMCA7LN DMCA7LN DN Oxycodone hydrochloride DMCA7LN MI DE4LYSA DMCA7LN MN Cytochrome P450 3A4 (CYP3A4) DMCA7LN MT DME DMCA7LN MA Metabolism DMCA7LN RN Metabolism and disposition of prescription opioids: a review. Forensic Sci Rev. 2015 Jul;27(2):115-45. DMCA7LN RU https://www.ncbi.nlm.nih.gov/pubmed/?term=26227254 DMCA7LN DI DMCA7LN DMCA7LN DN Oxycodone hydrochloride DMCA7LN MI DEIBDNY DMCA7LN MN Cytochrome P450 3A5 (CYP3A5) DMCA7LN MT DME DMCA7LN MA Metabolism DMCA7LN RN Quantitative contribution of CYP2D6 and CYP3A to oxycodone metabolism in human liver and intestinal microsomes. Drug Metab Dispos. 2004 Apr;32(4):447-54. DMCA7LN RU https://www.ncbi.nlm.nih.gov/pubmed/?term=15039299 DMCA7LN DI DMCA7LN DMCA7LN DN Oxycodone hydrochloride DMCA7LN MI DERD86B DMCA7LN MN Cytochrome P450 3A7 (CYP3A7) DMCA7LN MT DME DMCA7LN MA Metabolism DMCA7LN RN Quantitative contribution of CYP2D6 and CYP3A to oxycodone metabolism in human liver and intestinal microsomes. Drug Metab Dispos. 2004 Apr;32(4):447-54. DMCA7LN RU https://www.ncbi.nlm.nih.gov/pubmed/?term=15039299 DMC7EQT DI DMC7EQT DMC7EQT DN AAB-002 DMC7EQT MI TTE4KHA DMC7EQT MN Amyloid beta A4 protein (APP) DMC7EQT MT DTT DMC7EQT MA Modulator DMC7EQT RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2402). DMC7EQT RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2402 DM3V8JN DI DM3V8JN DM3V8JN DN Anti-CD19 CAR T cells DM3V8JN MI TTW640A DM3V8JN MN B-lymphocyte surface antigen B4 (CD19) DM3V8JN MT DTT DM3V8JN MA CAR-T-Cell-Therapy DM3V8JN RN ClinicalTrials.gov (NCT02277522) CD19 Redirected Autologous T Cells for Hodgkin Lymphoma DM3V8JN RU https://clinicaltrials.gov/ct2/show/NCT02277522 DMYZ3O9 DI DMYZ3O9 DMYZ3O9 DN Autologous Anti-CD 123 CAR TCR/4-1BB-expressing T-lymphocytes DMYZ3O9 MI TTENHJ0 DMYZ3O9 MN Interleukin 3 receptor alpha (IL3RA) DMYZ3O9 MT DTT DMYZ3O9 MA CAR-T-Cell-Therapy DMYZ3O9 RN ClinicalTrials.gov (NCT02623582) CD123 Redirected Autologous T Cells for AML DMYZ3O9 RU https://clinicaltrials.gov/ct2/show/NCT02623582 DMFRA38 DI DMFRA38 DMFRA38 DN CART19 cells DMFRA38 MI TTW640A DMFRA38 MN B-lymphocyte surface antigen B4 (CD19) DMFRA38 MT DTT DMFRA38 MA CAR-T-Cell-Therapy DMFRA38 RN ClinicalTrials.gov (NCT02624258) Pilot Study of Non-Viral, RNA-Redirected Autologous T Cells in Patients With Refractory or Relapsed Hodgkin Lymphoma DMFRA38 RU https://clinicaltrials.gov/ct2/show/NCT02624258 DMA85ND DI DMA85ND DMA85ND DN ET-1 DMA85ND MI DEXKD7J DMA85ND MN Carboxypeptidase A4 (CPA4) DMA85ND MT DME DMA85ND MA Metabolism DMA85ND RN Rapid degradation of endothelin-1 by an enzyme released by the rat isolated perfused mesentery. Br J Pharmacol. 1995 Feb;114(4):867-71. DMA85ND RU https://www.ncbi.nlm.nih.gov/pubmed/?term=7773548 DMA85ND DI DMA85ND DMA85ND DN ET-1 DMA85ND MI TTKRD0G DMA85ND MN Endothelin A receptor (EDNRA) DMA85ND MT DTT DMA85ND MA Inhibitor DMA85ND RN 5-OHKF and NorKA, depsipeptides from a Hawaiian collection of Bryopsis pennata: binding properties for NorKA to the human neuropeptide Y Y1 receptor. J Nat Prod. 2009 Dec;72(12):2172-6. DMA85ND RU https://pubmed.ncbi.nlm.nih.gov/19916528 DMA85ND DI DMA85ND DMA85ND DN ET-1 DMA85ND MI TT3ZTGU DMA85ND MN Endothelin B receptor (EDNRB) DMA85ND MT DTT DMA85ND MA Inhibitor DMA85ND RN IRL 2500: A potent ETB selective endothelin antagonist, Bioorg. Med. Chem. Lett. 6(19):2323-2328 (1996). DMA85ND RU http://www.sciencedirect.com/science/article/pii/0960894X96004210 DMIUZEX DI DMIUZEX DMIUZEX DN (R)-PFI-2 DMIUZEX MI TTJ0FSU DMIUZEX MN Histone-lysine N-methyltransferase SETD7 (SETD7) DMIUZEX MT DTT DMIUZEX MA Inhibitor DMIUZEX RN (R)-PFI-2 is a potent and selective inhibitor of SETD7 methyltransferase activity in cells. Proc Natl Acad Sci U S A. 2014 Sep 2;111(35):12853-8. DMIUZEX RU https://pubmed.ncbi.nlm.nih.gov/25136132 DMXWD08 DI DMXWD08 DMXWD08 DN (R)-Xamoterol DMXWD08 MI DTT79CX DMXWD08 MN Organic cation transporter 1 (SLC22A1) DMXWD08 MT DTP DMXWD08 MA Substrate DMXWD08 RN Identification of novel substrates and structure-activity relationship of cellular uptake mediated by human organic cation transporters 1 and 2. J Med Chem. 2013 Sep 26;56(18):7232-42. DMXWD08 RU http://www.ncbi.nlm.nih.gov/pubmed/23984907 DMEJYV4 DI DMEJYV4 DMEJYV4 DN (S)-4-(Ethylsulfonyl)benzoylalanine DMEJYV4 MI TTT3IXG DMEJYV4 MN Kynurenine oxoglutarate transaminase II (AADAT) DMEJYV4 MT DTT DMEJYV4 MA Inhibitor DMEJYV4 RN Specific inhibition of kynurenate synthesis enhances extracellular dopamine levels in the rodent striatum. Neuroscience. 2009 Mar 3;159(1):196-203. DMEJYV4 RU https://pubmed.ncbi.nlm.nih.gov/19138730 DM1ZQ5G DI DM1ZQ5G DM1ZQ5G DN (S)-Xamoterol DM1ZQ5G MI DTT79CX DM1ZQ5G MN Organic cation transporter 1 (SLC22A1) DM1ZQ5G MT DTP DM1ZQ5G MA Substrate DM1ZQ5G RN Identification of novel substrates and structure-activity relationship of cellular uptake mediated by human organic cation transporters 1 and 2. J Med Chem. 2013 Sep 26;56(18):7232-42. DM1ZQ5G RU http://www.ncbi.nlm.nih.gov/pubmed/23984907 DM9TQDE DI DM9TQDE DM9TQDE DN 111In-hEGF DM9TQDE MI TTGKNB4 DM9TQDE MN Epidermal growth factor receptor (EGFR) DM9TQDE MT DTT DM9TQDE MA Modulator DM9TQDE RN A comparison of EGF and MAb 528 labeled with 111In for imaging human breast cancer. J Nucl Med. 2000 May;41(5):903-11. DM9TQDE RU https://pubmed.ncbi.nlm.nih.gov/10809207 DM5IUN8 DI DM5IUN8 DM5IUN8 DN 12B9m DM5IUN8 MI TTPCG5T DM5IUN8 MN Hepcidin (HAMP) DM5IUN8 MT DTT DM5IUN8 MA Inhibitor DM5IUN8 RN Pharmacokinetics of anti-hepcidin monoclonal antibody Ab 12B9m and hepcidin in cynomolgus monkeys. AAPS J. 2010 Dec;12(4):646-57. DM5IUN8 RU https://pubmed.ncbi.nlm.nih.gov/20737261 DM503DN DI DM503DN DM503DN DN 1954U89 DM503DN MI TTYZVDJ DM503DN MN Dihydrofolate reductase (DHFR) DM503DN MT DTT DM503DN MA Modulator DM503DN RN The pharmacokinetics of 1954U89, 1,3-diamino-7-(1-ethylpropyl)-8-methyl-7H-pyrrolo-(3,2-f)quinazoline, in dogs and rats after intravenous and oral administration. Biopharm Drug Dispos. 1997 Jul;18(5):433-42. DM503DN RU https://pubmed.ncbi.nlm.nih.gov/9210981 DMT8SFV DI DMT8SFV DMT8SFV DN 1-methyl-L-tryptophan DMT8SFV MI TTZJYKH DMT8SFV MN Indoleamine 2,3-dioxygenase 1 (IDO1) DMT8SFV MT DTT DMT8SFV MA Inhibitor DMT8SFV RN Discovery of tryptanthrin derivatives as potent inhibitors of indoleamine 2,3-dioxygenase with therapeutic activity in Lewis lung cancer (LLC) tumor-bearing mice. J Med Chem. 2013 Nov 14;56(21):8321-31. DMT8SFV RU https://pubmed.ncbi.nlm.nih.gov/24099220 DMIS1G7 DI DMIS1G7 DMIS1G7 DN 2-(1H-indole-3,-carbonyl)-thiazole-4-carboxylic acid methyl ester DMIS1G7 MI TT037IE DMIS1G7 MN Aryl hydrocarbon receptor (AHR) DMIS1G7 MT DTT DMIS1G7 MA Agonist DMIS1G7 RN 1'H-Indole-3'-Carbonyl-Thiazole-4-Carboxylic Acid Methyl Ester Blocked Human Glioma Cell Invasion via Aryl Hydrocarbon Receptor's Regulation of Cytoskeletal Contraction. Biomed Res Int. 2020 Oct 3;2020:2616930. DMIS1G7 RU https://pubmed.ncbi.nlm.nih.gov/33083460 DMLVADH DI DMLVADH DMLVADH DN 212Pb-labelled aCD37 DMLVADH MI TTFCW29 DMLVADH MN Leukocyte antigen CD37 (CD37) DMLVADH MT DTT DMLVADH RN Radiopharmaceutical therapy in cancer: clinical advances and challenges. Nat Rev Drug Discov. 2020 Sep;19(9):589-608. DMLVADH RU https://pubmed.ncbi.nlm.nih.gov/32728208 DM1O2C3 DI DM1O2C3 DM1O2C3 DN 227Th-labelled HER2-TTC DM1O2C3 MI TT6EO5L DM1O2C3 MN Erbb2 tyrosine kinase receptor (HER2) DM1O2C3 MT DTT DM1O2C3 RN Radiopharmaceutical therapy in cancer: clinical advances and challenges. Nat Rev Drug Discov. 2020 Sep;19(9):589-608. DM1O2C3 RU https://pubmed.ncbi.nlm.nih.gov/32728208 DM1R3VC DI DM1R3VC DM1R3VC DN 2-Amino-4-[3-hydroxyphenyl]-4-hydroxybutanoic acid DM1R3VC MI TTWQM3J DM1R3VC MN Kynureninase (KYNU) DM1R3VC MT DTT DM1R3VC MA Inhibitor DM1R3VC RN 2-Amino-4-[3'-hydroxyphenyl]-4-hydroxybutanoic acid; a potent inhibitor of rat and recombinant human kynureninase. Bioorg Med Chem Lett. 2002 Feb 11;12(3):361-3. DM1R3VC RU https://pubmed.ncbi.nlm.nih.gov/11814797 DMRDQPT DI DMRDQPT DMRDQPT DN 2-D08 DMRDQPT MI TTW30FR DMRDQPT MN Small ubiquitin-related modifier (SUMO) DMRDQPT MT DTT DMRDQPT MA Inhibitor DMRDQPT RN Inhibiting SUMO1-mediated SUMOylation induces autophagy-mediated cancer cell death and reduces tumour cell invasion via RAC1. J Cell Sci. 2019 Oct 22;132(20):jcs234120. DMRDQPT RU https://pubmed.ncbi.nlm.nih.gov/31578236 DM4NURZ DI DM4NURZ DM4NURZ DN 2E9IgA1 DM4NURZ MI TTTB3L1 DM4NURZ MN Alpha-crystallin (CRYA) DM4NURZ MT DTT DM4NURZ MA Inhibitor DM4NURZ RN A novel human IgA monoclonal antibody protects against tuberculosis. J Immunol. 2011 Mar 1;186(5):3113-9. DM4NURZ RU https://pubmed.ncbi.nlm.nih.gov/21257971 DMAM4FE DI DMAM4FE DMAM4FE DN 2-Ethoxypropanoic acid DMAM4FE MI TT5MLZR DMAM4FE MN Cryptochrome circadian clock 1 (CRY1) DMAM4FE MT DTT DMAM4FE MA Inhibitor DMAM4FE RN The cryptochrome inhibitor KS15 enhances E-box-mediated transcription by disrupting the feedback action of a circadian transcription-repressor complex. Life Sci. 2018 May 1;200:49-55. DMAM4FE RU https://pubmed.ncbi.nlm.nih.gov/29534992 DMAM4FE DI DMAM4FE DMAM4FE DN 2-Ethoxypropanoic acid DMAM4FE MI TTAO58M DMAM4FE MN Cryptochrome-2 (CRY2) DMAM4FE MT DTT DMAM4FE MA Inhibitor DMAM4FE RN The cryptochrome inhibitor KS15 enhances E-box-mediated transcription by disrupting the feedback action of a circadian transcription-repressor complex. Life Sci. 2018 May 1;200:49-55. DMAM4FE RU https://pubmed.ncbi.nlm.nih.gov/29534992 DM5CVBM DI DM5CVBM DM5CVBM DN 3-Oxo-C12-(2-amino-cyclohexanone) DM5CVBM MI TTOMVUW DM5CVBM MN Pseudomonas Transcriptional activator protein LasR (Pseudo LasR) DM5CVBM MT DTT DM5CVBM MA Agonist DM5CVBM RN Different drugs for bad bugs: antivirulence strategies in the age of antibiotic resistance. Nat Rev Drug Discov. 2017 Jul;16(7):457-471. DM5CVBM RU https://pubmed.ncbi.nlm.nih.gov/28337021 DM57GL1 DI DM57GL1 DM57GL1 DN 4-(4-fluoropyrazol-1-yl)-1,2-oxazol-5-amine DM57GL1 MI TTXNCBV DM57GL1 MN Tryptophan 2,3-dioxygenase (TDO) DM57GL1 MT DTT DM57GL1 MA Inhibitor DM57GL1 RN Tryptophan metabolism as a common therapeutic target in cancer, neurodegeneration and beyond. Nat Rev Drug Discov. 2019 May;18(5):379-401. DM57GL1 RU https://pubmed.ncbi.nlm.nih.gov/30760888 DMXFC3W DI DMXFC3W DMXFC3W DN 4SC-202 DMXFC3W MI TT6R7JZ DMXFC3W MN Histone deacetylase 1 (HDAC1) DMXFC3W MT DTT DMXFC3W MA Inhibitor DMXFC3W RN 2011 Pipeline of 4SC AG. DMXFC3W RU http://www.pharmaceutical-market-research.com/publications/pharmaceutical_companies/4sc_ag_product_pipeline_review.html DMAJWLD DI DMAJWLD DMAJWLD DN 5-(4-(4-Acetylphenyl)piperazin-1-ylsulfonyl)-6-chloroindolin-2-one DMAJWLD MI TTLPC70 DMAJWLD MN Lysosomal alpha-glucosidase (GAA) DMAJWLD MT DTT DMAJWLD MA Inhibitor DMAJWLD RN 5-(4-(4-Acetylphenyl)piperazin-1-ylsulfonyl)indolin-2-one Analogs as Inhibitors of Acid alpha-Glucosidase for Potential Chaperone Treatment of Pompe Disease or Intervention for Diabetes Mellitus Type 2. N.A.. N.A. DMAJWLD RU https://pubmed.ncbi.nlm.nih.gov/23905200 DMC4IUQ DI DMC4IUQ DMC4IUQ DN 5-(N,N-hexamethylene)-amiloride DMC4IUQ MI TT2NUT5 DMC4IUQ MN Adrenergic receptor alpha-2C (ADRA2C) DMC4IUQ MT DTT DMC4IUQ MA Modulator (allosteric modulator) DMC4IUQ RN Characterization of the allosteric interactions between antagonists and amiloride analogues at the human alpha2A-adrenergic receptor. Mol Pharmacol. 1998 May;53(5):916-25. DMC4IUQ RU https://pubmed.ncbi.nlm.nih.gov/9584219 DMC4IUQ DI DMC4IUQ DMC4IUQ DN 5-(N,N-hexamethylene)-amiloride DMC4IUQ MI TT8R70G DMC4IUQ MN Gonadotropin-releasing hormone receptor (GNRHR) DMC4IUQ MT DTT DMC4IUQ MA Modulator (allosteric modulator) DMC4IUQ RN Amiloride derivatives and a nonpeptidic antagonist bind at two distinct allosteric sites in the human gonadotropin-releasing hormone receptor. Mol Pharmacol. 2008 Jun;73(6):1808-15. DMC4IUQ RU https://pubmed.ncbi.nlm.nih.gov/18344315 DM7RHOC DI DM7RHOC DM7RHOC DN 5N,6S-(N'-butyliminomethylidene)-6-thio-1-deoxygalactonojirimycin DM7RHOC MI TTNGJPH DM7RHOC MN Beta-galactosidase (GLB1) DM7RHOC MT DTT DM7RHOC MA Inhibitor DM7RHOC RN A bicyclic 1-deoxygalactonojirimycin derivative as a novel pharmacological chaperone for GM1 gangliosidosis. Mol Ther. 2013 Mar;21(3):526-32. DM7RHOC RU https://pubmed.ncbi.nlm.nih.gov/23337983 DMCDTIG DI DMCDTIG DMCDTIG DN 680C91 DMCDTIG MI TTXNCBV DMCDTIG MN Tryptophan 2,3-dioxygenase (TDO) DMCDTIG MT DTT DMCDTIG MA Inhibitor DMCDTIG RN Effects of IDO1 and TDO2 inhibition on cognitive deficits and anxiety following LPS-induced neuroinflammation. Acta Neuropsychiatr. 2020 Feb;32(1):43-53. DMCDTIG RU https://pubmed.ncbi.nlm.nih.gov/31753057 DMEKMV0 DI DMEKMV0 DMEKMV0 DN 9-(Ethoxyimino)-9H-indeno[1,2-b]pyrazine-2,3-dicarbonitrile DMEKMV0 MI TT1J07C DMEKMV0 MN Ubiquitin isopeptidase Y (USP8) DMEKMV0 MT DTT DMEKMV0 MA Inhibitor DMEKMV0 RN Synthesis and biological evaluation of 9-oxo-9H-indeno[1,2-b]pyrazine-2,3-dicarbonitrile analogues as potential inhibitors of deubiquitinating enzymes. ChemMedChem. 2010 Apr 6;5(4):552-8. DMEKMV0 RU https://pubmed.ncbi.nlm.nih.gov/20186914 DMFP316 DI DMFP316 DMFP316 DN A-196 DMFP316 MI TTJGV7F DMFP316 MN Histone-lysine N-methyltransferase KMT5B (KMT5B) DMFP316 MT DTT DMFP316 MA Inhibitor DMFP316 RN The SUV4-20 inhibitor A-196 verifies a role for epigenetics in genomic integrity. Nat Chem Biol. 2017 Mar;13(3):317-324. DMFP316 RU https://pubmed.ncbi.nlm.nih.gov/28114273 DMFP316 DI DMFP316 DMFP316 DN A-196 DMFP316 MI TT7H3YM DMFP316 MN Histone-lysine N-methyltransferase KMT5C (KMT5C) DMFP316 MT DTT DMFP316 MA Inhibitor DMFP316 RN The SUV4-20 inhibitor A-196 verifies a role for epigenetics in genomic integrity. Nat Chem Biol. 2017 Mar;13(3):317-324. DMFP316 RU https://pubmed.ncbi.nlm.nih.gov/28114273 DM1H45U DI DM1H45U DM1H45U DN A-366 DM1H45U MI TTOFXD7 DM1H45U MN Euchromatic histone-lysine N-methyltransferase 1 (EHMT1) DM1H45U MT DTT DM1H45U MA Inhibitor DM1H45U RN Discovery and development of potent and selective inhibitors of histone methyltransferase g9a. ACS Med Chem Lett. 2014 Jan 2;5(2):205-9. DM1H45U RU https://pubmed.ncbi.nlm.nih.gov/24900801 DM1H45U DI DM1H45U DM1H45U DN A-366 DM1H45U MI TTS6RZT DM1H45U MN Histone-lysine N-methyltransferase EHMT2 (EHMT2) DM1H45U MT DTT DM1H45U MA Inhibitor DM1H45U RN Discovery and development of potent and selective inhibitors of histone methyltransferase g9a. ACS Med Chem Lett. 2014 Jan 2;5(2):205-9. DM1H45U RU https://pubmed.ncbi.nlm.nih.gov/24900801 DML5SO1 DI DML5SO1 DML5SO1 DN A-366833 DML5SO1 MI TTL1ATN DML5SO1 MN Neuronal acetylcholine receptor alpha-4/beta-2 (CHRNA4/B2) DML5SO1 MT DTT DML5SO1 MA Modulator DML5SO1 RN Antinociceptive activity of alpha4beta2* neuronal nicotinic receptor agonist A-366833 in experimental models of neuropathic and inflammatory pain. Eur J Pharmacol. 2011 Oct 1;668(1-2):155-62. DML5SO1 RU https://pubmed.ncbi.nlm.nih.gov/21756895 DMECV6L DI DMECV6L DMECV6L DN A-425619 DMECV6L MI TTMI6F5 DMECV6L MN Transient receptor potential cation channel V1 (TRPV1) DMECV6L MT DTT DMECV6L MA Blocker DMECV6L RN Analgesic potential of TRPV1 antagonists. Biochem Pharmacol. 2009 Aug 1;78(3):211-6. DMECV6L RU https://pubmed.ncbi.nlm.nih.gov/19481638 DMZ4HMP DI DMZ4HMP DMZ4HMP DN A-71378 DMZ4HMP MI TTCG0AL DMZ4HMP MN Cholecystokinin receptor type A (CCKAR) DMZ4HMP MT DTT DMZ4HMP MA Agonist DMZ4HMP RN Emerging drugs for obesity: linking novel biological mechanisms to pharmaceutical pipelines. Expert Opin Emerg Drugs. 2005 Aug;10(3):643-60. DMZ4HMP RU https://pubmed.ncbi.nlm.nih.gov/16083333 DMAK6H3 DI DMAK6H3 DMAK6H3 DN A-74498 DMAK6H3 MI TTCG0AL DMAK6H3 MN Cholecystokinin receptor type A (CCKAR) DMAK6H3 MT DTT DMAK6H3 MA Agonist DMAK6H3 RN Emerging drugs for obesity: linking novel biological mechanisms to pharmaceutical pipelines. Expert Opin Emerg Drugs. 2005 Aug;10(3):643-60. DMAK6H3 RU https://pubmed.ncbi.nlm.nih.gov/16083333 DMSO8IE DI DMSO8IE DMSO8IE DN A-841720 DMSO8IE MI TTVBPDM DMSO8IE MN Metabotropic glutamate receptor 1 (mGluR1) DMSO8IE MT DTT DMSO8IE MA Antagonist DMSO8IE RN Comparison of the mGluR1 antagonist A-841720 in rat models of pain and cognition. Behav Pharmacol. 2007 Jul;18(4):273-81. DMSO8IE RU https://pubmed.ncbi.nlm.nih.gov/17551319 DM8XHJG DI DM8XHJG DM8XHJG DN A-893 DM8XHJG MI TT7YJFO DM8XHJG MN SET and MYND domain-containing protein 2 (SMYD2) DM8XHJG MT DTT DM8XHJG MA Inhibitor DM8XHJG RN Discovery of A-893, A New Cell-Active Benzoxazinone Inhibitor of Lysine Methyltransferase SMYD2. ACS Med Chem Lett. 2015 Apr 29;6(6):695-700. DM8XHJG RU https://pubmed.ncbi.nlm.nih.gov/26101576 DMRSATG DI DMRSATG DMRSATG DN Abamectin B1A DMRSATG MI DTUGYRD DMRSATG MN P-glycoprotein 1 (ABCB1) DMRSATG MT DTP DMRSATG MA Substrate DMRSATG RN Interaction of macrocyclic lactones with P-glycoprotein: structure-affinity relationship. Eur J Pharm Sci. 2007 Jan;30(1):84-94. DMRSATG RU https://doi.org/10.1016/j.ejps.2006.10.004 DMQ0NU1 DI DMQ0NU1 DMQ0NU1 DN ABI-013 DMQ0NU1 MI TTML2WA DMQ0NU1 MN Tubulin (TUB) DMQ0NU1 MT DTT DMQ0NU1 RN Cardiovascular and CNS safety profile of ABI-013, a novel nanoparticle albumin-bound (nab) analog of docetaxel. Cancer Research. 01/2011; 70(8 Supplement):2617-2617. DMQ0NU1 RU http://cancerres.aacrjournals.org/content/70/8_Supplement/2617.short DMKUPW0 DI DMKUPW0 DMKUPW0 DN ABX-0401 DMKUPW0 MI TTF8CQI DMKUPW0 MN Tumor necrosis factor (TNF) DMKUPW0 MT DTT DMKUPW0 MA Inhibitor DMKUPW0 RN US patent application no. 8007,790, Methods for treating polycystic kidney disease (pkd) or other cyst forming diseases. DMKUPW0 RU http://worldwide.espacenet.com/publicationDetails/biblio?DB=worldwide.espacenet.com&II=0&ND=3&adjacent=true&locale=en_EP&FT=D&date=20081030&CC=US&NR=2008269123A1&KC=A1 DMBI1H2 DI DMBI1H2 DMBI1H2 DN AD-529 DMBI1H2 MI TT9IK2Z DMBI1H2 MN N-methyl-D-aspartate receptor (NMDAR) DMBI1H2 MT DTT DMBI1H2 MA Antagonist DMBI1H2 RN WO patent application no. 2009,0164,86, Use of nmda receptor antagonists for treatment of urologic tumors. DMBI1H2 RU http://worldwide.espacenet.com/publicationDetails/biblio?DB=worldwide.espacenet.com&II=0&ND=3&adjacent=true&locale=en_EP&FT=D&date=20090205&CC=WO&NR=2009016486A2&KC=A2 DM19R28 DI DM19R28 DM19R28 DN ADC-01 DM19R28 MI TTXU3EQ DM19R28 MN Herpesvirus ubiquitin-specific protease (HAUSP) DM19R28 MT DTT DM19R28 MA Inhibitor DM19R28 RN Advances in Deubiquitinating Enzyme Inhibition and Applications in Cancer Therapeutics. Cancers (Basel). 2020 Jun 15;12(6):1579. DM19R28 RU https://pubmed.ncbi.nlm.nih.gov/32549302 DM21I35 DI DM21I35 DM21I35 DN ADC-03 DM21I35 MI TTXU3EQ DM21I35 MN Herpesvirus ubiquitin-specific protease (HAUSP) DM21I35 MT DTT DM21I35 MA Inhibitor DM21I35 RN Advances in Deubiquitinating Enzyme Inhibition and Applications in Cancer Therapeutics. Cancers (Basel). 2020 Jun 15;12(6):1579. DM21I35 RU https://pubmed.ncbi.nlm.nih.gov/32549302 DM2WKDN DI DM2WKDN DM2WKDN DN ADX-2 series DM2WKDN MI TT9IK2Z DM2WKDN MN N-methyl-D-aspartate receptor (NMDAR) DM2WKDN MT DTT DM2WKDN MA Antagonist DM2WKDN RN The pipeline and future of drug development in schizophrenia. Mol Psychiatry. 2007 Oct;12(10):904-22. DM2WKDN RU https://pubmed.ncbi.nlm.nih.gov/17667958 DMEWFOL DI DMEWFOL DMEWFOL DN ADX-71943 DMEWFOL MI TTDCVZW DMEWFOL MN Gamma-aminobutyric acid B receptor (GABBR) DMEWFOL MT DTT DMEWFOL MA Modulator DMEWFOL RN Evaluation of peripheral versus central effects of GABA(B) receptor activation using a novel, positive allosteric modulator of the GABA(B) receptor ADX71943, a pharmacological tool compound with a fully peripheral activity profile. Br J Pharmacol. 2014 Nov;171(21):4941-54. DMEWFOL RU https://pubmed.ncbi.nlm.nih.gov/24923436 DM13YRT DI DM13YRT DM13YRT DN AEOL-10150 DM13YRT MI TT6RVLG DM13YRT MN Superoxide dismutase Cu-Zn (SOD Cu-Zn) DM13YRT MT DTT DM13YRT MA Modulator DM13YRT RN AEOL-10150 (Aeolus). Curr Opin Investig Drugs. 2006 Jan;7(1):70-80. DM13YRT RU https://pubmed.ncbi.nlm.nih.gov/16425674 DMYIK5D DI DMYIK5D DMYIK5D DN AEZS-123 DMYIK5D MI TTWDC17 DMYIK5D MN Growth hormone secretagogue receptor 1 (GHSR) DMYIK5D MT DTT DMYIK5D MA Antagonist DMYIK5D RN 2011 Pipeline of Aeterna Zentaris. DMYIK5D RU http://www.aezsinc.com/en/index.php DM648KQ DI DM648KQ DM648KQ DN ALN-FLU01 DM648KQ MI TTM27B5 DM648KQ MN Influenza NA messenger RNA (Influenza NA mRNA) DM648KQ MT DTT DM648KQ RN Respiratory viral diseases: access to RNA interference therapy. Drug Discov Today Ther Strateg. 2007; 4(4): 273-276. DM648KQ RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2597863/ DM8T6H7 DI DM8T6H7 DM8T6H7 DN ALN-HTT DM8T6H7 MI TTIWZ0O DM8T6H7 MN Huntingtin messenger RNA (HTT mRNA) DM8T6H7 MT DTT DM8T6H7 RN Clinical pipeline report, company report or official report of Alnylam Pharmaceuticals, Inc (2011). DM8T6H7 RU http://www.alnylam.com/Programs-and-Pipeline/index.php DMCJMOS DI DMCJMOS DMCJMOS DN ALN-PCS DMCJMOS MI TTNIZ2B DMCJMOS MN PCSK9 messenger RNA (PCSK9 mRNA) DMCJMOS MT DTT DMCJMOS RN Clinical pipeline report, company report or official report of Alnylam Pharmaceuticals, Inc (2011). DMCJMOS RU http://www.alnylam.com/Programs-and-Pipeline/index.php DMW7XEU DI DMW7XEU DMW7XEU DN ALN-TMP DMW7XEU MI TTNIUKC DMW7XEU MN TMPRSS6 messenger RNA (TMPRSS6 mRNA) DMW7XEU MT DTT DMW7XEU MA Inhibitor DMW7XEU RN Targeting iron metabolism in drug discovery and delivery. Nat Rev Drug Discov. 2017 Jun;16(6):400-423. DMW7XEU RU https://pubmed.ncbi.nlm.nih.gov/28154410 DMATQB7 DI DMATQB7 DMATQB7 DN Alpha-Helical lipopeptides FFS DMATQB7 MI TT85VHW DMATQB7 MN MERS-CoV spike glycoprotein (S) DMATQB7 MT DTT DMATQB7 MA Inhibitor DMATQB7 RN De Novo Design of -Helical Lipopeptides Targeting Viral Fusion Proteins: A Promising Strategy for Relatively Broad-Spectrum Antiviral Drug Discovery. J Med Chem. 2018 Oct 11;61(19):8734-8745. DMATQB7 RU https://pubmed.ncbi.nlm.nih.gov/30192544 DMVSKQF DI DMVSKQF DMVSKQF DN Alpha-Helical lipopeptides IIK DMVSKQF MI TT85VHW DMVSKQF MN MERS-CoV spike glycoprotein (S) DMVSKQF MT DTT DMVSKQF MA Inhibitor DMVSKQF RN De Novo Design of -Helical Lipopeptides Targeting Viral Fusion Proteins: A Promising Strategy for Relatively Broad-Spectrum Antiviral Drug Discovery. J Med Chem. 2018 Oct 11;61(19):8734-8745. DMVSKQF RU https://pubmed.ncbi.nlm.nih.gov/30192544 DM1MGBX DI DM1MGBX DM1MGBX DN Alpha-Helical lipopeptides IIS DM1MGBX MI TT85VHW DM1MGBX MN MERS-CoV spike glycoprotein (S) DM1MGBX MT DTT DM1MGBX MA Inhibitor DM1MGBX RN De Novo Design of -Helical Lipopeptides Targeting Viral Fusion Proteins: A Promising Strategy for Relatively Broad-Spectrum Antiviral Drug Discovery. J Med Chem. 2018 Oct 11;61(19):8734-8745. DM1MGBX RU https://pubmed.ncbi.nlm.nih.gov/30192544 DM3WVM4 DI DM3WVM4 DM3WVM4 DN Alpha-Helical lipopeptides LLS DM3WVM4 MI TT85VHW DM3WVM4 MN MERS-CoV spike glycoprotein (S) DM3WVM4 MT DTT DM3WVM4 MA Inhibitor DM3WVM4 RN De Novo Design of -Helical Lipopeptides Targeting Viral Fusion Proteins: A Promising Strategy for Relatively Broad-Spectrum Antiviral Drug Discovery. J Med Chem. 2018 Oct 11;61(19):8734-8745. DM3WVM4 RU https://pubmed.ncbi.nlm.nih.gov/30192544 DMQMAWK DI DMQMAWK DMQMAWK DN Alpha-Zearalenol DMQMAWK MI DTFI42L DMQMAWK MN Multidrug resistance-associated protein 2 (ABCC2) DMQMAWK MT DTP DMQMAWK MA Substrate DMQMAWK RN ABCC1, ABCC2 and ABCC3 are implicated in the transepithelial transport of the myco-estrogen zearalenone and its major metabolites. Toxicol Lett. 2009 Oct 28;190(2):215-23. DMQMAWK RU https://doi.org/10.1016/j.toxlet.2009.07.021 DM2U16Z DI DM2U16Z DM2U16Z DN ANAVEX 1007 DM2U16Z MI TT5TPI6 DM2U16Z MN Opioid receptor sigma 1 (OPRS1) DM2U16Z MT DTT DM2U16Z MA Agonist DM2U16Z RN 2011 Pipeline of Anavex. DM2U16Z RU http://anavex.com/pipeline.html DM2U16Z DI DM2U16Z DM2U16Z DN ANAVEX 1007 DM2U16Z MI TT9NXW4 DM2U16Z MN Sigma intracellular receptor 2 (TMEM97) DM2U16Z MT DTT DM2U16Z MA Agonist DM2U16Z RN 2011 Pipeline of Anavex. DM2U16Z RU http://anavex.com/pipeline.html DM1MQON DI DM1MQON DM1MQON DN ANAVEX 1-41 DM1MQON MI TT5TPI6 DM1MQON MN Opioid receptor sigma 1 (OPRS1) DM1MQON MT DTT DM1MQON MA Agonist DM1MQON RN 2011 Pipeline of Anavex. DM1MQON RU http://anavex.com/pipeline.html DM61TDB DI DM61TDB DM61TDB DN ARI-809 DM61TDB MI TTFBNVI DM61TDB MN Aldose reductase (AKR1B1) DM61TDB MT DTT DM61TDB MA Inhibitor DM61TDB RN A selective aldose reductase inhibitor of a new structural class prevents or reverses early retinal abnormalities in experimental diabetic retinopathy. Diabetes. 2006 Oct;55(10):2757-62. DM61TDB RU https://pubmed.ncbi.nlm.nih.gov/17003340 DMMD8VY DI DMMD8VY DMMD8VY DN AR-R-1589 DMMD8VY MI TTCG0AL DMMD8VY MN Cholecystokinin receptor type A (CCKAR) DMMD8VY MT DTT DMMD8VY MA Agonist DMMD8VY RN Emerging drugs for obesity: linking novel biological mechanisms to pharmaceutical pipelines. Expert Opin Emerg Drugs. 2005 Aug;10(3):643-60. DMMD8VY RU https://pubmed.ncbi.nlm.nih.gov/16083333 DMRPX4W DI DMRPX4W DMRPX4W DN ASP8497 DMRPX4W MI TTDIGC1 DMRPX4W MN Dipeptidyl peptidase 4 (DPP-4) DMRPX4W MT DTT DMRPX4W MA Inhibitor DMRPX4W RN Emerging drug candidates of dipeptidyl peptidase IV (DPP IV) inhibitor class for the treatment of Type 2 Diabetes. Curr Drug Targets. 2009 Jan;10(1):71-87. DMRPX4W RU https://pubmed.ncbi.nlm.nih.gov/19149538 DM34FEA DI DM34FEA DM34FEA DN ATA2431 DM34FEA MI TTM6QSK DM34FEA MN B-cell receptor CD22 (CD22) DM34FEA MT DTT DM34FEA RN Clinical pipeline report, company report or official report of Atara Biotherapeutics. DM34FEA RU https://www.atarabio.com/pipeline/ DM34FEA DI DM34FEA DM34FEA DN ATA2431 DM34FEA MI TTW640A DM34FEA MN B-lymphocyte surface antigen B4 (CD19) DM34FEA MT DTT DM34FEA RN Clinical pipeline report, company report or official report of Atara Biotherapeutics. DM34FEA RU https://www.atarabio.com/pipeline/ DM34FEA DI DM34FEA DM34FEA DN ATA2431 DM34FEA MI TTUE541 DM34FEA MN Leukocyte surface antigen Leu-16 (CD20) DM34FEA MT DTT DM34FEA RN Clinical pipeline report, company report or official report of Atara Biotherapeutics. DM34FEA RU https://www.atarabio.com/pipeline/ DMJTYH3 DI DMJTYH3 DMJTYH3 DN ATA3219 DMJTYH3 MI TTW640A DMJTYH3 MN B-lymphocyte surface antigen B4 (CD19) DMJTYH3 MT DTT DMJTYH3 RN Clinical pipeline report, company report or official report of Atara Biotherapeutics. DMJTYH3 RU https://www.atarabio.com/pipeline/ DMXQVBT DI DMXQVBT DMXQVBT DN ATA3271 DMXQVBT MI TT4RXME DMXQVBT MN Mesothelin (MSLN) DMXQVBT MT DTT DMXQVBT RN Clinical pipeline report, company report or official report of Atara Biotherapeutics. DMXQVBT RU https://www.atarabio.com/pipeline/ DMZJVR5 DI DMZJVR5 DMZJVR5 DN ATI-17000 DMZJVR5 MI TTPC4TU DMZJVR5 MN 5-HT 3A receptor (HTR3A) DMZJVR5 MT DTT DMZJVR5 MA Antagonist DMZJVR5 RN Emerging drugs for irritable bowel syndrome. Expert Opin Emerg Drugs. 2006 May;11(2):293-313. DMZJVR5 RU https://pubmed.ncbi.nlm.nih.gov/16634703 DMZJVR5 DI DMZJVR5 DMZJVR5 DN ATI-17000 DMZJVR5 MI TTNT7K8 DMZJVR5 MN Nociceptin receptor (OPRL1) DMZJVR5 MT DTT DMZJVR5 MA Antagonist DMZJVR5 RN Nocistatin and nociceptin given centrally induce opioid-mediated gastric mucosal protection. Peptides. 2008 Dec;29(12):2257-65. DMZJVR5 RU https://pubmed.ncbi.nlm.nih.gov/18930088 DM4XZU2 DI DM4XZU2 DM4XZU2 DN ATL-1101 DM4XZU2 MI TTQFBMY DM4XZU2 MN IGF1R messenger RNA (IGF1R mRNA) DM4XZU2 MT DTT DM4XZU2 RN Clinical pipeline report, company report or official report of Antisense Therapeutics. DM4XZU2 RU http://www.antisense.com.au/product-pipeline/atl1101-for-prostate-cancer/ DM0KM6F DI DM0KM6F DM0KM6F DN AUNP-12 DM0KM6F MI TTNBFWK DM0KM6F MN Programmed cell death protein 1 (PD-1) DM0KM6F MT DTT DM0KM6F MA Inhibitor DM0KM6F RN Development of Inhibitors of the Programmed Cell Death-1/Programmed Cell Death-Ligand 1 Signaling Pathway.J Med Chem. 2019 Feb 28;62(4):1715-1730. DM0KM6F RU https://pubmed.ncbi.nlm.nih.gov/30247903 DMKQ20J DI DMKQ20J DMKQ20J DN AZ505 DMKQ20J MI TT7YJFO DMKQ20J MN SET and MYND domain-containing protein 2 (SMYD2) DMKQ20J MT DTT DMKQ20J MA Inhibitor DMKQ20J RN Structural basis of substrate methylation and inhibition of SMYD2. Structure. 2011 Sep 7;19(9):1262-73. DMKQ20J RU https://pubmed.ncbi.nlm.nih.gov/21782458 DMY7R3X DI DMY7R3X DMY7R3X DN AZD-1678 DMY7R3X MI TT7HQD0 DMY7R3X MN C-C chemokine receptor type 4 (CCR4) DMY7R3X MT DTT DMY7R3X MA Antagonist DMY7R3X RN Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800030818) DMY7R3X RU http://adisinsight.springer.com/drugs/800030818 DM3FLMR DI DM3FLMR DM3FLMR DN Azidothymidine monophosphate DM3FLMR MI DTI7UX6 DM3FLMR MN Breast cancer resistance protein (ABCG2) DM3FLMR MT DTP DM3FLMR MA Substrate DM3FLMR RN Role of the breast cancer resistance protein (ABCG2) in drug transport. AAPS J. 2005 May 11;7(1):E118-33. DM3FLMR RU https://doi.org/10.1208/aapsj070112 DM3FLMR DI DM3FLMR DM3FLMR DN Azidothymidine monophosphate DM3FLMR MI DTCSGPB DM3FLMR MN Multidrug resistance-associated protein 4 (ABCC4) DM3FLMR MT DTP DM3FLMR MA Substrate DM3FLMR RN MRP4: A previously unidentified factor in resistance to nucleoside-based antiviral drugs. Nat Med. 1999 Sep;5(9):1048-51. DM3FLMR RU https://doi.org/10.1038/12487 DMOW07D DI DMOW07D DMOW07D DN BAP-15 DMOW07D MI TTGYTMA DMOW07D MN Isopeptidase T (USP5) DMOW07D MT DTT DMOW07D MA Inhibitor DMOW07D RN The proteasome deubiquitinase inhibitor bAP15 downregulates TGF-/Smad signaling and induces apoptosis via UCHL5 inhibition in ovarian cancer. Oncotarget. 2019 Oct 15;10(57):5932-5948. DMOW07D RU https://pubmed.ncbi.nlm.nih.gov/31666925 DMOW07D DI DMOW07D DMOW07D DN BAP-15 DMOW07D MI TTVSYP9 DMOW07D MN Ubiquitin carboxyl-terminal hydrolase 14 (USP14) DMOW07D MT DTT DMOW07D MA Inhibitor DMOW07D RN The proteasome deubiquitinase inhibitor bAP15 downregulates TGF-/Smad signaling and induces apoptosis via UCHL5 inhibition in ovarian cancer. Oncotarget. 2019 Oct 15;10(57):5932-5948. DMOW07D RU https://pubmed.ncbi.nlm.nih.gov/31666925 DMTJZIL DI DMTJZIL DMTJZIL DN Barasertib-hQPA DMTJZIL MI DTI7UX6 DMTJZIL MN Breast cancer resistance protein (ABCG2) DMTJZIL MT DTP DMTJZIL MA Substrate DMTJZIL RN P-glycoprotein and breast cancer resistance protein in acute myeloid leukaemia cells treated with the aurora-B kinase inhibitor barasertib-hQPA. BMC Cancer. 2011 Jun 16;11:254. DMTJZIL RU https://doi.org/10.1186/1471-2407-11-254 DM92VRP DI DM92VRP DM92VRP DN Batimastat DM92VRP MI TTUZ2L5 DM92VRP MN Matrix metalloproteinase-3 (MMP-3) DM92VRP MT DTT DM92VRP MA Modulator DM92VRP RN Matrix metalloproteinase inhibitor BB-94 (batimastat) inhibits human colon tumor growth and spread in a patient-like orthotopic model in nude mice. Cancer Res. 1994 Sep 1;54(17):4726-8. DM92VRP RU https://www.ncbi.nlm.nih.gov/pubmed/8062271 DMWH19X DI DMWH19X DMWH19X DN BAY 598 DMWH19X MI TT7YJFO DMWH19X MN SET and MYND domain-containing protein 2 (SMYD2) DMWH19X MT DTT DMWH19X MA Inhibitor DMWH19X RN Discovery and Characterization of a Highly Potent and Selective Aminopyrazoline-Based in Vivo Probe (BAY-598) for the Protein Lysine Methyltransferase SMYD2. J Med Chem. 2016 May 26;59(10):4578-600. DMWH19X RU https://pubmed.ncbi.nlm.nih.gov/27075367 DMTEJV1 DI DMTEJV1 DMTEJV1 DN BAY 60-6583 DMTEJV1 MI TTK25J1 DMTEJV1 MN Adenosine A1 receptor (ADORA1) DMTEJV1 MT DTT DMTEJV1 MA Agonist DMTEJV1 RN Protein kinase C protects preconditioned rabbit hearts by increasing sensitivity of adenosine A2b-dependent signaling during early reperfusion. J Mol Cell Cardiol. 2007 Sep;43(3):262-71. DMTEJV1 RU https://pubmed.ncbi.nlm.nih.gov/17632123 DMTEJV1 DI DMTEJV1 DMTEJV1 DN BAY 60-6583 DMTEJV1 MI TTNE7KG DMTEJV1 MN Adenosine A2b receptor (ADORA2B) DMTEJV1 MT DTT DMTEJV1 MA Agonist DMTEJV1 RN Cardioprotection by ecto-5'-nucleotidase (CD73) and A2B adenosine receptors. Circulation. 2007 Mar 27;115(12):1581-90. DMTEJV1 RU https://pubmed.ncbi.nlm.nih.gov/17353435 DMTEJV1 DI DMTEJV1 DMTEJV1 DN BAY 60-6583 DMTEJV1 MI TTJFY5U DMTEJV1 MN Adenosine A3 receptor (ADORA3) DMTEJV1 MT DTT DMTEJV1 MA Agonist DMTEJV1 RN Protein kinase C protects preconditioned rabbit hearts by increasing sensitivity of adenosine A2b-dependent signaling during early reperfusion. J Mol Cell Cardiol. 2007 Sep;43(3):262-71. DMTEJV1 RU https://pubmed.ncbi.nlm.nih.gov/17632123 DMVESTF DI DMVESTF DMVESTF DN BAY-38-1315 DMVESTF MI TTFQAYR DMVESTF MN Cholesteryl ester transfer protein (CETP) DMVESTF MT DTT DMVESTF MA Inhibitor DMVESTF RN Chromanol derivatives--a novel class of CETP inhibitors. Bioorg Med Chem Lett. 2011 Jan 1;21(1):488-91. DMVESTF RU https://pubmed.ncbi.nlm.nih.gov/21084191 DM3EUBA DI DM3EUBA DM3EUBA DN BC-1215 DM3EUBA MI TTUX14L DM3EUBA MN F-box only protein 3 (FBXO3) DM3EUBA MT DTT DM3EUBA MA Antagonist DM3EUBA RN Targeting F box protein Fbxo3 to control cytokine-driven inflammation. J Immunol. 2013 Nov 15;191(10):5247-55. DM3EUBA RU https://pubmed.ncbi.nlm.nih.gov/24123678 DMSJ2I6 DI DMSJ2I6 DMSJ2I6 DN Beta-aminopropionitrile DMSJ2I6 MI TTFSUHX DMSJ2I6 MN Lysyl oxidase homolog 2 (LOXL2) DMSJ2I6 MT DTT DMSJ2I6 MA Inhibitor DMSJ2I6 RN Wnt signaling and Loxl2 promote aggressive osteosarcoma. Cell Res. 2020 Oct;30(10):885-901. DMSJ2I6 RU https://pubmed.ncbi.nlm.nih.gov/32686768 DM6BGJ9 DI DM6BGJ9 DM6BGJ9 DN BFF-122 DM6BGJ9 MI TTT3IXG DM6BGJ9 MN Kynurenine oxoglutarate transaminase II (AADAT) DM6BGJ9 MT DTT DM6BGJ9 MA Inhibitor DM6BGJ9 RN Tryptophan metabolism as a common therapeutic target in cancer, neurodegeneration and beyond. Nat Rev Drug Discov. 2019 May;18(5):379-401. DM6BGJ9 RU https://pubmed.ncbi.nlm.nih.gov/30760888 DMK3SAF DI DMK3SAF DMK3SAF DN BI-D1870 DMK3SAF MI TTIXKA4 DMK3SAF MN Ribosomal protein S6 kinase alpha-1 (RSK1) DMK3SAF MT DTT DMK3SAF MA Inhibitor DMK3SAF RN BI-D1870 is a specific inhibitor of the p90 RSK (ribosomal S6 kinase) isoforms in vitro and in vivo. Biochem J. 2007 Jan 1;401(1):29-38. DMK3SAF RU https://pubmed.ncbi.nlm.nih.gov/17040210 DMK3SAF DI DMK3SAF DMK3SAF DN BI-D1870 DMK3SAF MI TT0ZW9O DMK3SAF MN Ribosomal protein S6 kinase alpha-2 (RSK2) DMK3SAF MT DTT DMK3SAF MA Inhibitor DMK3SAF RN BI-D1870 is a specific inhibitor of the p90 RSK (ribosomal S6 kinase) isoforms in vitro and in vivo. Biochem J. 2007 Jan 1;401(1):29-38. DMK3SAF RU https://pubmed.ncbi.nlm.nih.gov/17040210 DMK3SAF DI DMK3SAF DMK3SAF DN BI-D1870 DMK3SAF MI TTUM2ZR DMK3SAF MN Ribosomal protein S6 kinase alpha-3 (RSK3) DMK3SAF MT DTT DMK3SAF MA Inhibitor DMK3SAF RN BI-D1870 is a specific inhibitor of the p90 RSK (ribosomal S6 kinase) isoforms in vitro and in vivo. Biochem J. 2007 Jan 1;401(1):29-38. DMK3SAF RU https://pubmed.ncbi.nlm.nih.gov/17040210 DMK3SAF DI DMK3SAF DMK3SAF DN BI-D1870 DMK3SAF MI TT3KYWB DMK3SAF MN Ribosomal protein S6 kinase alpha-6 (RSK6) DMK3SAF MT DTT DMK3SAF MA Inhibitor DMK3SAF RN BI-D1870 is a specific inhibitor of the p90 RSK (ribosomal S6 kinase) isoforms in vitro and in vivo. Biochem J. 2007 Jan 1;401(1):29-38. DMK3SAF RU https://pubmed.ncbi.nlm.nih.gov/17040210 DM2JOXF DI DM2JOXF DM2JOXF DN BIIR-777 DM2JOXF MI TTAN6JD DM2JOXF MN Glutamate receptor AMPA (GRIA) DM2JOXF MT DTT DM2JOXF MA Modulator DM2JOXF RN Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41. DM2JOXF RU https://www.ncbi.nlm.nih.gov/pubmed/15950434 DMPUBK8 DI DMPUBK8 DMPUBK8 DN BIO-306 DMPUBK8 MI TT27RFC DMPUBK8 MN Opioid receptor delta (OPRD1) DMPUBK8 MT DTT DMPUBK8 MA Agonist DMPUBK8 RN Pharmacologic therapeutics for cardiac reperfusion injury. Expert Opin Emerg Drugs. 2007 Sep;12(3):367-88. DMPUBK8 RU https://pubmed.ncbi.nlm.nih.gov/17874967 DM5CBNY DI DM5CBNY DM5CBNY DN BIX-01294 DM5CBNY MI TTOFXD7 DM5CBNY MN Euchromatic histone-lysine N-methyltransferase 1 (EHMT1) DM5CBNY MT DTT DM5CBNY MA Inhibitor DM5CBNY RN Reversal of H3K9me2 by a small-molecule inhibitor for the G9a histone methyltransferase. Mol Cell. 2007 Feb 9;25(3):473-81. DM5CBNY RU https://pubmed.ncbi.nlm.nih.gov/17289593 DM5CBNY DI DM5CBNY DM5CBNY DN BIX-01294 DM5CBNY MI TTS6RZT DM5CBNY MN Histone-lysine N-methyltransferase EHMT2 (EHMT2) DM5CBNY MT DTT DM5CBNY MA Inhibitor DM5CBNY RN Reversal of H3K9me2 by a small-molecule inhibitor for the G9a histone methyltransferase. Mol Cell. 2007 Feb 9;25(3):473-81. DM5CBNY RU https://pubmed.ncbi.nlm.nih.gov/17289593 DMDJH2L DI DMDJH2L DMDJH2L DN BMS 536924 DMDJH2L MI DTI7UX6 DMDJH2L MN Breast cancer resistance protein (ABCG2) DMDJH2L MT DTP DMDJH2L MA Substrate DMDJH2L RN Drug efflux by breast cancer resistance protein is a mechanism of resistance to the benzimidazole insulin-like growth factor receptor/insulin receptor inhibitor, BMS-536924. Mol Cancer Ther. 2011 Jan;10(1):117-25. DMDJH2L RU https://doi.org/10.1158/1535-7163.MCT-10-0438 DMHAWBR DI DMHAWBR DMHAWBR DN BMS-192548 DMHAWBR MI TTJ6WK9 DMHAWBR MN Neuropeptide Y receptor type 2 (NPY2R) DMHAWBR MT DTT DMHAWBR MA Antagonist DMHAWBR RN Emerging drugs for obesity: linking novel biological mechanisms to pharmaceutical pipelines. Expert Opin Emerg Drugs. 2005 Aug;10(3):643-60. DMHAWBR RU https://pubmed.ncbi.nlm.nih.gov/16083333 DMCWIBU DI DMCWIBU DMCWIBU DN BMS-3870032 DMCWIBU MI DTUGYRD DMCWIBU MN P-glycoprotein 1 (ABCB1) DMCWIBU MT DTP DMCWIBU MA Substrate DMCWIBU RN Human intestinal transporter database: QSAR modeling and virtual profiling of drug uptake, efflux and interactions. Pharm Res. 2013 Apr;30(4):996-1007. DMCWIBU RU https://doi.org/10.1007/s11095-012-0935-x DMQG39T DI DMQG39T DMQG39T DN BMS-695735 DMQG39T MI TTRLW2X DMQG39T MN Fibroblast growth factor receptor 1 (FGFR1) DMQG39T MT DTT DMQG39T MA Inhibitor DMQG39T RN Discovery and evaluation of 4-(2-(4-chloro-1H-pyrazol-1-yl)ethylamino)-3-(6-(1-(3-fluoropropyl)piperidin-4-yl)-4-methyl-1H-benzo[d]imidazol-2-yl)py... J Med Chem. 2008 Oct 9;51(19):5897-900. DMQG39T RU https://pubmed.ncbi.nlm.nih.gov/18763755 DMQG39T DI DMQG39T DMQG39T DN BMS-695735 DMQG39T MI TTHRID2 DMQG39T MN Insulin-like growth factor I receptor (IGF1R) DMQG39T MT DTT DMQG39T MA Inhibitor DMQG39T RN Discovery and evaluation of 4-(2-(4-chloro-1H-pyrazol-1-yl)ethylamino)-3-(6-(1-(3-fluoropropyl)piperidin-4-yl)-4-methyl-1H-benzo[d]imidazol-2-yl)py... J Med Chem. 2008 Oct 9;51(19):5897-900. DMQG39T RU https://pubmed.ncbi.nlm.nih.gov/18763755 DM4BZEJ DI DM4BZEJ DM4BZEJ DN BMS-986118 DM4BZEJ MI TTB8FUC DM4BZEJ MN Free fatty acid receptor 1 (GPR40) DM4BZEJ MT DTT DM4BZEJ MA Agonist DM4BZEJ RN Discovery of Potent and Orally Bioavailable Dihydropyrazole GPR40 Agonists. J Med Chem. 2018 Feb 8;61(3):681-694. DM4BZEJ RU https://pubmed.ncbi.nlm.nih.gov/29316397 DM8TAI9 DI DM8TAI9 DM8TAI9 DN BMS-986202 DM8TAI9 MI TTQ6S1K DM8TAI9 MN Lysophosphatidic acid receptor 1 (LPAR1) DM8TAI9 MT DTT DM8TAI9 MA Antagonist DM8TAI9 RN Pharmacokinetic and pharmacodynamic characterization of an oral lysophosphatidic acid type 1 receptor-selective antagonist. J Pharmacol Exp Ther. 2011 Mar;336(3):693-700. DM8TAI9 RU https://pubmed.ncbi.nlm.nih.gov/21159750 DMRCMEK DI DMRCMEK DMRCMEK DN BMS-PCSK9 DMRCMEK MI TTNIZ2B DMRCMEK MN PCSK9 messenger RNA (PCSK9 mRNA) DMRCMEK MT DTT DMRCMEK RN Clinical pipeline report, company report or official report of ISIS Pharmaceuticals (2011). DMRCMEK RU http://www.isispharm.com/index.htm DMCPQJ9 DI DMCPQJ9 DMCPQJ9 DN BN-AA-003-NY DMCPQJ9 MI TTZAYWL DMCPQJ9 MN Estrogen receptor (ESR) DMCPQJ9 MT DTT DMCPQJ9 MA Modulator DMCPQJ9 RN Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800023897) DMCPQJ9 RU http://adisinsight.springer.com/drugs/800023897 DMVMY4X DI DMVMY4X DMVMY4X DN BN-AO-014 DMVMY4X MI TTZAYWL DMVMY4X MN Estrogen receptor (ESR) DMVMY4X MT DTT DMVMY4X MA Modulator DMVMY4X RN Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800023897) DMVMY4X RU http://adisinsight.springer.com/drugs/800023897 DMM1O0P DI DMM1O0P DMM1O0P DN BNC-102 DMM1O0P MI TTY6C71 DMM1O0P MN G-protein coupled receptor 48 (LGR4) DMM1O0P MT DTT DMM1O0P MA Inhibitor DMM1O0P RN Opportunities for therapeutic antibodies directed at G-protein-coupled receptors. Nat Rev Drug Discov. 2017 Sep 1;16(9):661. DMM1O0P RU https://pubmed.ncbi.nlm.nih.gov/28860586 DMM1O0P DI DMM1O0P DMM1O0P DN BNC-102 DMM1O0P MI TTTSGRH DMM1O0P MN Leucine-rich repeat-containing GPCR 5 (LGR5) DMM1O0P MT DTT DMM1O0P MA Inhibitor DMM1O0P RN Opportunities for therapeutic antibodies directed at G-protein-coupled receptors. Nat Rev Drug Discov. 2017 Sep 1;16(9):661. DMM1O0P RU https://pubmed.ncbi.nlm.nih.gov/28860586 DMBPTDC DI DMBPTDC DMBPTDC DN BN-CB-045 DMBPTDC MI TTZAYWL DMBPTDC MN Estrogen receptor (ESR) DMBPTDC MT DTT DMBPTDC MA Modulator DMBPTDC RN Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800023897) DMBPTDC RU http://adisinsight.springer.com/drugs/800023897 DMFNLE6 DI DMFNLE6 DMFNLE6 DN BN-DF-037 DMFNLE6 MI TTZAYWL DMFNLE6 MN Estrogen receptor (ESR) DMFNLE6 MT DTT DMFNLE6 MA Modulator DMFNLE6 RN Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800023897) DMFNLE6 RU http://adisinsight.springer.com/drugs/800023897 DM0PJU9 DI DM0PJU9 DM0PJU9 DN BN-GU-005-DHP DM0PJU9 MI TTZAYWL DM0PJU9 MN Estrogen receptor (ESR) DM0PJU9 MT DTT DM0PJU9 MA Modulator DM0PJU9 RN Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800023897) DM0PJU9 RU http://adisinsight.springer.com/drugs/800023897 DM8WDAL DI DM8WDAL DM8WDAL DN BN-OD-026 DM8WDAL MI TTZAYWL DM8WDAL MN Estrogen receptor (ESR) DM8WDAL MT DTT DM8WDAL MA Modulator DM8WDAL RN Clinical pipeline report, company report or official report of Bionovo. DM8WDAL RU http://bionovo.com/investors/pr/MjAxMTEyMDgwODAw DM5O3HC DI DM5O3HC DM5O3HC DN Bouvardin DM5O3HC MI DTUGYRD DM5O3HC MN P-glycoprotein 1 (ABCB1) DM5O3HC MT DTP DM5O3HC MA Substrate DM5O3HC RN Fingerprint-based in silico models for the prediction of P-glycoprotein substrates and inhibitors. Bioorg Med Chem. 2012 Sep 15;20(18):5388-95. DM5O3HC RU https://doi.org/10.1016/j.bmc.2012.03.045 DMT2C78 DI DMT2C78 DMT2C78 DN Brensocatib DMT2C78 MI TTQ9J6R DMT2C78 MN HUMAN dipeptidyl peptidase 1 (CTSC) DMT2C78 MT DTT DMT2C78 MA Inhibitor DMT2C78 RN Brensocatib (Formerly INS1007) to be Studied in Patients with Severe COVID-19 in Investigator-Initiated Trial. Apr 23, 2020. DMT2C78 RU https://www.biospace.com/article/releases/brensocatib-formerly-ins1007-to-be-studied-in-patients-with-severe-covid-19-in-investigator-initiated-trial/ DMO15TX DI DMO15TX DMO15TX DN BSF-78438 DMO15TX MI TTZFYLI DMO15TX MN Dopamine D1 receptor (D1R) DMO15TX MT DTT DMO15TX MA Binder DMO15TX RN The pipeline and future of drug development in schizophrenia. Mol Psychiatry. 2007 Oct;12(10):904-22. DMO15TX RU https://pubmed.ncbi.nlm.nih.gov/17667958 DM3WHB2 DI DM3WHB2 DM3WHB2 DN BST-1005 DM3WHB2 MI TTNS7H3 DM3WHB2 MN Laminin gamma-2 subunit (LAMC2) DM3WHB2 MT DTT DM3WHB2 RN Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800019225) DM3WHB2 RU http://adisinsight.springer.com/drugs/800019225 DMT4532 DI DMT4532 DMT4532 DN Bunitrolol DMT4532 MI DTUGYRD DMT4532 MN P-glycoprotein 1 (ABCB1) DMT4532 MT DTP DMT4532 MA Substrate DMT4532 RN Contribution of P-glycoprotein to bunitrolol efflux across blood-brain barrier. Biopharm Drug Dispos. 1999 Mar;20(2):85-90. DMT4532 RU https://doi.org/10.1002/(SICI)1099-081X(199903)20:2<85::AID-BDD159>3.0.CO;2-3 DMDSX58 DI DMDSX58 DMDSX58 DN BVT-A DMDSX58 MI TTKMAZ6 DMDSX58 MN Growth hormone receptor (GHR) DMDSX58 MT DTT DMDSX58 MA Antagonist DMDSX58 RN Emerging drugs for acromegaly. Expert Opin Emerg Drugs. 2008 Jun;13(2):273-93. DMDSX58 RU https://pubmed.ncbi.nlm.nih.gov/18537521 DMY9F1M DI DMY9F1M DMY9F1M DN C30 DMY9F1M MI TTOMVUW DMY9F1M MN Pseudomonas Transcriptional activator protein LasR (Pseudo LasR) DMY9F1M MT DTT DMY9F1M MA Inhibitor DMY9F1M RN Different drugs for bad bugs: antivirulence strategies in the age of antibiotic resistance. Nat Rev Drug Discov. 2017 Jul;16(7):457-471. DMY9F1M RU https://pubmed.ncbi.nlm.nih.gov/28337021 DMVN3FU DI DMVN3FU DMVN3FU DN CA-074Me DMVN3FU MI TTF2LRI DMVN3FU MN Cathepsin B (CTSB) DMVN3FU MT DTT DMVN3FU MA Inhibitor DMVN3FU RN CA-074Me inhibits Cathepsin-B and alleviates fibrosis after myocardial infarction. Panminerva Med. 2019 Sep 24. DMVN3FU RU https://pubmed.ncbi.nlm.nih.gov/31577087 DM9HG6S DI DM9HG6S DM9HG6S DN CAR-T cells targeting CD117 DM9HG6S MI TTX41N9 DM9HG6S MN Tyrosine-protein kinase Kit (KIT) DM9HG6S MT DTT DM9HG6S MA CAR-T-Cell-Therapy DM9HG6S RN ClinicalTrials.gov (NCT03473457) CAR-T Cells Therapy in Relapsed/Refractory Acute Myeloid Leukemia DM9HG6S RU https://clinicaltrials.gov/ct2/show/NCT03473457 DMSZNQE DI DMSZNQE DMSZNQE DN CAR-T cells targeting CD123 DMSZNQE MI TTENHJ0 DMSZNQE MN Interleukin 3 receptor alpha (IL3RA) DMSZNQE MT DTT DMSZNQE MA CAR-T-Cell-Therapy DMSZNQE RN ClinicalTrials.gov (NCT03473457) CAR-T Cells Therapy in Relapsed/Refractory Acute Myeloid Leukemia DMSZNQE RU https://clinicaltrials.gov/ct2/show/NCT03473457 DMYOR5T DI DMYOR5T DMYOR5T DN CAR-T cells targeting CD133 DMYOR5T MI TTXMZ81 DMYOR5T MN Prominin-1 (PROM1) DMYOR5T MT DTT DMYOR5T MA CAR-T-Cell-Therapy DMYOR5T RN ClinicalTrials.gov (NCT03473457) CAR-T Cells Therapy in Relapsed/Refractory Acute Myeloid Leukemia DMYOR5T RU https://clinicaltrials.gov/ct2/show/NCT03473457 DMH7BT9 DI DMH7BT9 DMH7BT9 DN CAR-T cells targeting CD33 DMH7BT9 MI TTJVYO3 DMH7BT9 MN Myeloid cell surface antigen CD33 (CD33) DMH7BT9 MT DTT DMH7BT9 MA CAR-T-Cell-Therapy DMH7BT9 RN ClinicalTrials.gov (NCT03473457) CAR-T Cells Therapy in Relapsed/Refractory Acute Myeloid Leukemia DMH7BT9 RU https://clinicaltrials.gov/ct2/show/NCT03473457 DM3G0OP DI DM3G0OP DM3G0OP DN CAR-T cells targeting CD34 DM3G0OP MI TTZAVYN DM3G0OP MN Hematopoietic progenitor cell antigen CD34 (CD34) DM3G0OP MT DTT DM3G0OP MA CAR-T-Cell-Therapy DM3G0OP RN ClinicalTrials.gov (NCT03473457) CAR-T Cells Therapy in Relapsed/Refractory Acute Myeloid Leukemia DM3G0OP RU https://clinicaltrials.gov/ct2/show/NCT03473457 DMA1BLC DI DMA1BLC DMA1BLC DN CAR-T cells targeting Mucl DMA1BLC MI TTBHFYQ DMA1BLC MN Mucin-1 (MUC1) DMA1BLC MT DTT DMA1BLC MA CAR-T-Cell-Therapy DMA1BLC RN ClinicalTrials.gov (NCT03473457) CAR-T Cells Therapy in Relapsed/Refractory Acute Myeloid Leukemia DMA1BLC RU https://clinicaltrials.gov/ct2/show/NCT03473457 DMDUKMR DI DMDUKMR DMDUKMR DN CAT4001 DMDUKMR MI TTA6ZN2 DMDUKMR MN Nuclear factor erythroid 2-related factor 2 (Nrf2) DMDUKMR MT DTT DMDUKMR MA Activator DMDUKMR RN Therapeutic targeting of the NRF2 and KEAP1 partnership in chronic diseases. Nat Rev Drug Discov. 2019 Apr;18(4):295-317. DMDUKMR RU https://pubmed.ncbi.nlm.nih.gov/30610225 DMKFAG3 DI DMKFAG3 DMKFAG3 DN CB-01-16 DMKFAG3 MI TTN4QDT DMKFAG3 MN Opioid receptor (OPR) DMKFAG3 MT DTT DMKFAG3 MA Antagonist DMKFAG3 RN Clinical pipeline report, company report or official report of Cosmo. DMKFAG3 RU http://www.cosmopharmaceuticals.com/activities/pipeline/cb-01-16.aspx DM53JW0 DI DM53JW0 DM53JW0 DN CB1 antagonist, Bayer DM53JW0 MI TT6OEDT DM53JW0 MN Cannabinoid receptor 1 (CB1) DM53JW0 MT DTT DM53JW0 MA Antagonist DM53JW0 RN Emerging drugs for obesity: linking novel biological mechanisms to pharmaceutical pipelines. Expert Opin Emerg Drugs. 2005 Aug;10(3):643-60. DM53JW0 RU https://pubmed.ncbi.nlm.nih.gov/16083333 DMJUQ6E DI DMJUQ6E DMJUQ6E DN CB7993113 DMJUQ6E MI TT037IE DMJUQ6E MN Aryl hydrocarbon receptor (AHR) DMJUQ6E MT DTT DMJUQ6E MA Antagonist DMJUQ6E RN In silico identification of an aryl hydrocarbon receptor antagonist with biological activity in vitro and in vivo. Mol Pharmacol. 2014 Nov;86(5):593-608. DMJUQ6E RU https://pubmed.ncbi.nlm.nih.gov/25159092 DMCFEUG DI DMCFEUG DMCFEUG DN CCG-208408 DMCFEUG MI DEUQTKA DMCFEUG MN Beta-glucosidase (bglA) DMCFEUG MT DME DMCFEUG MA Metabolism DMCFEUG RN Catabolism of citrus flavanones by the probiotics Bifidobacterium longum and Lactobacillus rhamnosus. Eur J Nutr. 2018 Feb;57(1):231-242. DMCFEUG RU https://pubmed.ncbi.nlm.nih.gov/27722779 DM065ZH DI DM065ZH DM065ZH DN CCT-018159 DM065ZH MI TT78R5H DM065ZH MN Heat shock protein 90 alpha (HSP90A) DM065ZH MT DTT DM065ZH MA Inhibitor DM065ZH RN Recent advances in Hsp90 inhibitors as antitumor agents. Anticancer Agents Med Chem. 2008 Oct;8(7):761-82. DM065ZH RU https://pubmed.ncbi.nlm.nih.gov/18855578 DMNA9KW DI DMNA9KW DMNA9KW DN CCT251545 DMNA9KW MI TTBJR4L DMNA9KW MN Cyclin-dependent kinase 8 (CDK8) DMNA9KW MT DTT DMNA9KW MA Inhibitor DMNA9KW RN Kinase inhibitors: the road ahead. Nat Rev Drug Discov. 2018 May;17(5):353-377. DMNA9KW RU https://pubmed.ncbi.nlm.nih.gov/29545548 DMWQIJX DI DMWQIJX DMWQIJX DN Celastrol DMWQIJX MI TTRYK0X DMWQIJX MN Interleukin-1 beta (IL1B) DMWQIJX MT DTT DMWQIJX MA Suppressor DMWQIJX RN Emerging disease-modifying therapies for the treatment of motor neuron disease/amyotropic lateral sclerosis. Expert Opin Emerg Drugs. 2007 May;12(2):229-52. DMWQIJX RU https://pubmed.ncbi.nlm.nih.gov/17604499 DMWQIJX DI DMWQIJX DMWQIJX DN Celastrol DMWQIJX MI TTF8CQI DMWQIJX MN Tumor necrosis factor (TNF) DMWQIJX MT DTT DMWQIJX MA Suppressor DMWQIJX RN Emerging disease-modifying therapies for the treatment of motor neuron disease/amyotropic lateral sclerosis. Expert Opin Emerg Drugs. 2007 May;12(2):229-52. DMWQIJX RU https://pubmed.ncbi.nlm.nih.gov/17604499 DM1ZFCS DI DM1ZFCS DM1ZFCS DN Cephaeline DM1ZFCS MI DTUGYRD DM1ZFCS MN P-glycoprotein 1 (ABCB1) DM1ZFCS MT DTP DM1ZFCS MA Substrate DM1ZFCS RN Fingerprint-based in silico models for the prediction of P-glycoprotein substrates and inhibitors. Bioorg Med Chem. 2012 Sep 15;20(18):5388-95. DM1ZFCS RU https://doi.org/10.1016/j.bmc.2012.03.045 DMQSJ20 DI DMQSJ20 DMQSJ20 DN CF502 DMQSJ20 MI TTJFY5U DMQSJ20 MN Adenosine A3 receptor (ADORA3) DMQSJ20 MT DTT DMQSJ20 MA Agonist DMQSJ20 RN 2011 Pipeline of Can-Fite BioPharm. DMQSJ20 RU http://www.canfite.com/pipeline.html DM0ULO2 DI DM0ULO2 DM0ULO2 DN CF602 DM0ULO2 MI TTJFY5U DM0ULO2 MN Adenosine A3 receptor (ADORA3) DM0ULO2 MT DTT DM0ULO2 MA Agonist DM0ULO2 RN 2011 Pipeline of Can-Fite BioPharm. DM0ULO2 RU http://www.canfite.com/pipeline.html DMYGITU DI DMYGITU DMYGITU DN CHDI-340246 DMYGITU MI TTIY56R DMYGITU MN Kynurenine 3-hydroxylase (KMO) DMYGITU MT DTT DMYGITU MA Inhibitor DMYGITU RN The novel KMO inhibitor CHDI-340246 leads to a restoration of electrophysiological alterations in mouse models of Huntington's disease. Exp Neurol. 2016 Aug;282:99-118. DMYGITU RU https://pubmed.ncbi.nlm.nih.gov/27163548 DM89DQP DI DM89DQP DM89DQP DN Chlamydocin DM89DQP MI TT6R7JZ DM89DQP MN Histone deacetylase 1 (HDAC1) DM89DQP MT DTT DM89DQP MA Inhibitor DM89DQP RN Histone deacetylase inhibitors in cancer therapy: latest developments, trends and medicinal chemistry perspective. Anticancer Agents Med Chem. 2007 Sep;7(5):576-92. DM89DQP RU https://pubmed.ncbi.nlm.nih.gov/17896917 DMAPO0T DI DMAPO0T DMAPO0T DN Ciglitazone DMAPO0T MI DES5XRU DMAPO0T MN Cytochrome P450 2C8 (CYP2C8) DMAPO0T MT DME DMAPO0T MA Metabolism DMAPO0T RN Effects of gemfibrozil, itraconazole, and their combination on the pharmacokinetics of pioglitazone. Clin Pharmacol Ther. 2005 May;77(5):404-14. DMAPO0T RU https://www.ncbi.nlm.nih.gov/pubmed/?term=15900286 DMAPO0T DI DMAPO0T DMAPO0T DN Ciglitazone DMAPO0T MI DE4LYSA DMAPO0T MN Cytochrome P450 3A4 (CYP3A4) DMAPO0T MT DME DMAPO0T MA Metabolism DMAPO0T RN Effects of gemfibrozil, itraconazole, and their combination on the pharmacokinetics of pioglitazone. Clin Pharmacol Ther. 2005 May;77(5):404-14. DMAPO0T RU https://www.ncbi.nlm.nih.gov/pubmed/?term=15900286 DMAPO0T DI DMAPO0T DMAPO0T DN Ciglitazone DMAPO0T MI TTZMAO3 DMAPO0T MN Peroxisome proliferator-activated receptor gamma (PPAR-gamma) DMAPO0T MT DTT DMAPO0T MA Agonist DMAPO0T RN New drugs in development for the treatment of endometriosis. Expert Opin Investig Drugs. 2008 Aug;17(8):1187-202. DMAPO0T RU https://pubmed.ncbi.nlm.nih.gov/18616415 DM37NYK DI DM37NYK DM37NYK DN Citrate DM37NYK MI DTFPWJ9 DM37NYK MN Sodium-coupled citrate transporter (SLC13A5) DM37NYK MT DTP DM37NYK MA Substrate DM37NYK RN SLC13 family of Na+ coupled di- and tri-carboxylate/sulfate transporters. Mol Aspects Med. 2013 Apr-Jun;34(2-3):299-312. DM37NYK RU http://www.ncbi.nlm.nih.gov/pubmed/23506872 DMV0RFU DI DMV0RFU DMV0RFU DN CKI-7 DMV0RFU MI TT7OGZP DMV0RFU MN Casein kinase 1 (CK1) DMV0RFU MT DTT DMV0RFU MA Inhibitor DMV0RFU RN Crystal structures of two aminoglycoside kinases bound with a eukaryotic protein kinase inhibitor. PLoS One. 2011 May 9;6(5):e19589. DMV0RFU RU https://pubmed.ncbi.nlm.nih.gov/21573013 DM6HADZ DI DM6HADZ DM6HADZ DN CL-314698 DM6HADZ MI TTMXGCW DM6HADZ MN Adrenergic receptor beta-3 (ADRB3) DM6HADZ MT DTT DM6HADZ MA Agonist DM6HADZ RN Emerging drugs for obesity: linking novel biological mechanisms to pharmaceutical pipelines. Expert Opin Emerg Drugs. 2005 Aug;10(3):643-60. DM6HADZ RU https://pubmed.ncbi.nlm.nih.gov/16083333 DM0BHL8 DI DM0BHL8 DM0BHL8 DN CLIK-148 DM0BHL8 MI TT36ETB DM0BHL8 MN Cathepsin L (CTSL) DM0BHL8 MT DTT DM0BHL8 MA Inhibitor DM0BHL8 RN Structure-based development of specific inhibitors for individual cathepsins and their medical applications. Proc Jpn Acad Ser B Phys Biol Sci. 2011;87(2):29-39. DM0BHL8 RU https://pubmed.ncbi.nlm.nih.gov/21321479 DMXKN6R DI DMXKN6R DMXKN6R DN CLIK-181 DMXKN6R MI TT36ETB DMXKN6R MN Cathepsin L (CTSL) DMXKN6R MT DTT DMXKN6R MA Inhibitor DMXKN6R RN Lysosomes as a therapeutic target. Nat Rev Drug Discov. 2019 Dec;18(12):923-948. DMXKN6R RU https://pubmed.ncbi.nlm.nih.gov/31477883 DMP9EJ7 DI DMP9EJ7 DMP9EJ7 DN CM-2236 DMP9EJ7 MI TTSQIFT DMP9EJ7 MN 5-HT 1A receptor (HTR1A) DMP9EJ7 MT DTT DMP9EJ7 MA Agonist DMP9EJ7 RN CN patent application no. 104151292, Indole derivative or a pharmaceutically acceptable salt thereof. DMP9EJ7 RU http://www.google.com/patents/CN104151292A?cl=en DMP9EJ7 DI DMP9EJ7 DMP9EJ7 DN CM-2236 DMP9EJ7 MI TTNGILX DMP9EJ7 MN Adrenergic receptor alpha-1A (ADRA1A) DMP9EJ7 MT DTT DMP9EJ7 MA Agonist DMP9EJ7 RN CN patent application no. 104151292, Indole derivative or a pharmaceutically acceptable salt thereof. DMP9EJ7 RU http://www.google.com/patents/CN104151292A?cl=en DMHAI0M DI DMHAI0M DMHAI0M DN CNSB-004 DMHAI0M MI TT4FDG6 DMHAI0M MN Voltage-gated calcium channel alpha Cav2.2 (CACNA1B) DMHAI0M MT DTT DMHAI0M MA Modulator DMHAI0M RN CNSB004 (Leconotide) causes antihyperalgesia without side effects when given intravenously: a comparison with ziconotide in a rat model of diabetic neuropathic pain. Pain Med. 2010 Feb;11(2):262-73. DMHAI0M RU https://pubmed.ncbi.nlm.nih.gov/20002322 DM1H8D6 DI DM1H8D6 DM1H8D6 DN CNX-011-67 DM1H8D6 MI TTB8FUC DM1H8D6 MN Free fatty acid receptor 1 (GPR40) DM1H8D6 MT DTT DM1H8D6 MA Inhibitor DM1H8D6 RN CNX-011-67, a novel GPR40 agonist, enhances glucose responsiveness, insulin secretion and islet insulin content in n-STZ rats and in islets from type 2 diabetic patients. BMC Pharmacol Toxicol. 2014 Mar 25;15:19. DM1H8D6 RU https://pubmed.ncbi.nlm.nih.gov/24666736 DMG3BE1 DI DMG3BE1 DMG3BE1 DN Coelenterazine DMG3BE1 MI DTUGYRD DMG3BE1 MN P-glycoprotein 1 (ABCB1) DMG3BE1 MT DTP DMG3BE1 MA Substrate DMG3BE1 RN Imaging reversal of multidrug resistance in living mice with bioluminescence: MDR1 P-glycoprotein transports coelenterazine. Proc Natl Acad Sci U S A. 2004 Feb 10;101(6):1702-7. DMG3BE1 RU https://doi.org/10.1073/pnas.0304326101 DMN0GTR DI DMN0GTR DMN0GTR DN COR100140 DMN0GTR MI TT2AST1 DMN0GTR MN Macrophage migration inhibitory factor (MIF) DMN0GTR MT DTT DMN0GTR MA Inhibitor DMN0GTR RN Cortical Pty Ltd Presents MIF Antagonist Data at World Congress on Inflammation. Cortical Pty Ltd. 2005. DMN0GTR RU http://www.cortical.com.au/downloads/20050901_mediarelease_MIF_Antagonist_Data.pdf DMLXMCB DI DMLXMCB DMLXMCB DN COR-D DMLXMCB MI TT1MG9E DMLXMCB MN Extracellular signal-regulated kinase 1 (ERK1) DMLXMCB MT DTT DMLXMCB MA Activator DMLXMCB RN Corchorusin-D directed apoptosis of K562 cells occurs through activation of mitochondrial and death receptor pathways and suppression of AKT/PKB pathway. Cell Physiol Biochem. 2012;30(4):915-26. DMLXMCB RU https://pubmed.ncbi.nlm.nih.gov/22965801 DMLXMCB DI DMLXMCB DMLXMCB DN COR-D DMLXMCB MI TT4TQBX DMLXMCB MN Extracellular signal-regulated kinase 2 (ERK2) DMLXMCB MT DTT DMLXMCB MA Activator DMLXMCB RN Corchorusin-D directed apoptosis of K562 cells occurs through activation of mitochondrial and death receptor pathways and suppression of AKT/PKB pathway. Cell Physiol Biochem. 2012;30(4):915-26. DMLXMCB RU https://pubmed.ncbi.nlm.nih.gov/22965801 DMLXMCB DI DMLXMCB DMLXMCB DN COR-D DMLXMCB MI TT0K6EO DMLXMCB MN Stress-activated protein kinase JNK1 (JNK1) DMLXMCB MT DTT DMLXMCB MA Activator DMLXMCB RN Corchorusin-D directed apoptosis of K562 cells occurs through activation of mitochondrial and death receptor pathways and suppression of AKT/PKB pathway. Cell Physiol Biochem. 2012;30(4):915-26. DMLXMCB RU https://pubmed.ncbi.nlm.nih.gov/22965801 DMLXMCB DI DMLXMCB DMLXMCB DN COR-D DMLXMCB MI TTHS0U8 DMLXMCB MN Stress-activated protein kinase JNK2 (JNK2) DMLXMCB MT DTT DMLXMCB MA Activator DMLXMCB RN Corchorusin-D directed apoptosis of K562 cells occurs through activation of mitochondrial and death receptor pathways and suppression of AKT/PKB pathway. Cell Physiol Biochem. 2012;30(4):915-26. DMLXMCB RU https://pubmed.ncbi.nlm.nih.gov/22965801 DMATUKO DI DMATUKO DMATUKO DN CP-114271 DMATUKO MI TTMXGCW DMATUKO MN Adrenergic receptor beta-3 (ADRB3) DMATUKO MT DTT DMATUKO MA Agonist DMATUKO RN Emerging drugs for obesity: linking novel biological mechanisms to pharmaceutical pipelines. Expert Opin Emerg Drugs. 2005 Aug;10(3):643-60. DMATUKO RU https://pubmed.ncbi.nlm.nih.gov/16083333 DMQGRC8 DI DMQGRC8 DMQGRC8 DN CPH-102 DMQGRC8 MI TTVDSZ0 DMQGRC8 MN Poly [ADP-ribose] polymerase 1 (PARP1) DMQGRC8 MT DTT DMQGRC8 MA Inhibitor DMQGRC8 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2771). DMQGRC8 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2771 DMWMBIV DI DMWMBIV DMWMBIV DN CRA1000 DMWMBIV MI TT7EFHR DMWMBIV MN Corticotropin-releasing factor receptor 1 (CRHR1) DMWMBIV MT DTT DMWMBIV MA Antagonist DMWMBIV RN A review of drug options in age-related macular degeneration therapy and potential new agents. Expert Opin Pharmacother. 2006 Dec;7(17):2355-68. DMWMBIV RU https://pubmed.ncbi.nlm.nih.gov/17109611 DM8AR0E DI DM8AR0E DM8AR0E DN Cruentaren DM8AR0E MI TTL2PXZ DM8AR0E MN Vacuolar-type proton ATPase catalytic A (v-ATPase-A) DM8AR0E MT DTT DM8AR0E MA Inhibitor DM8AR0E RN Novel antifungal agents, targets or therapeutic strategies for the treatment of invasive fungal diseases: a review of the literature (2005-2009). Rev Iberoam Micol. 2009 Mar 31;26(1):15-22. DM8AR0E RU https://pubmed.ncbi.nlm.nih.gov/19463273 DMB4FWX DI DMB4FWX DMB4FWX DN CS-00028 DMB4FWX MI TTBH0VX DMB4FWX MN Histone deacetylase (HDAC) DMB4FWX MT DTT DMB4FWX MA Antagonist DMB4FWX RN US patent application no. 2009,0162,329, Compositions comprising hdac inhibitors and methods of their use in restoring stem cell function and preventing heart failure. DMB4FWX RU https://www.google.com/patents/US20090162329 DMK230A DI DMK230A DMK230A DN CS-3030 DMK230A MI TTCIHJA DMK230A MN Coagulation factor Xa (F10) DMK230A MT DTT DMK230A MA Inhibitor DMK230A RN Semuloparin for the prevention of venous thromboembolic events in cancer patients. Drugs Today (Barc). 2012 Jul;48(7):451-7. DMK230A RU https://pubmed.ncbi.nlm.nih.gov/22844656 DMKVW25 DI DMKVW25 DMKVW25 DN Cu-anti-hAXL DMKVW25 MI TTZPY6J DMKVW25 MN Tyrosine-protein kinase UFO (AXL) DMKVW25 MT DTT DMKVW25 RN MicroPET/CT Imaging of AXL Downregulation by HSP90 Inhibition in Triple-Negative Breast Cancer. Contrast Media Mol Imaging. 2017 May 14;2017:1686525. DMKVW25 RU https://pubmed.ncbi.nlm.nih.gov/29097911 DMB1ET0 DI DMB1ET0 DMB1ET0 DN Cutamesine DMB1ET0 MI TT5TPI6 DMB1ET0 MN Opioid receptor sigma 1 (OPRS1) DMB1ET0 MT DTT DMB1ET0 MA Agonist DMB1ET0 RN Effect of SA4503, a novel sigma1 receptor agonist, against glutamate neurotoxicity in cultured rat retinal neurons. Eur J Pharmacol. 1998 Jan 19;342(1):105-11. DMB1ET0 RU https://pubmed.ncbi.nlm.nih.gov/9544798 DM8YUJT DI DM8YUJT DM8YUJT DN CWHM-12 DM8YUJT MI TTIQSVM DM8YUJT MN Integrin alpha-V/beta-6 (ITGAV/B6) DM8YUJT MT DTT DM8YUJT MA Inhibitor DM8YUJT RN Targeting of alphav integrin identifies a core molecular pathway that regulates fibrosis in several organs. Nat Med. 2013 Dec;19(12):1617-24. DM8YUJT RU https://pubmed.ncbi.nlm.nih.gov/24216753 DMKZCBE DI DMKZCBE DMKZCBE DN CX-1501 DMKZCBE MI TTAN6JD DMKZCBE MN Glutamate receptor AMPA (GRIA) DMKZCBE MT DTT DMKZCBE MA Modulator DMKZCBE RN Pharmacology of ampakine modulators: from AMPA receptors to synapses and behavior. Curr Drug Targets. 2007 May;8(5):583-602. DMKZCBE RU https://pubmed.ncbi.nlm.nih.gov/17504103 DMA1MK5 DI DMA1MK5 DMA1MK5 DN CYC-800 DMA1MK5 MI TTIYVQP DMA1MK5 MN Polo-like kinase 1 (PLK1) DMA1MK5 MT DTT DMA1MK5 MA Inhibitor DMA1MK5 RN Polo-like kinase (PLK) inhibitors in preclinical and early clinical development in oncology. Oncologist. 2009 Jun;14(6):559-70. DMA1MK5 RU https://pubmed.ncbi.nlm.nih.gov/19474163 DMV8APG DI DMV8APG DMV8APG DN Cytolin DMV8APG MI TT48WR6 DMV8APG MN Integrin alpha-L (ITGAL) DMV8APG MT DTT DMV8APG RN Cytokine-induced phagocyte adhesion to human mesangial cells: role of CD11/CD18 integrins and ICAM-1. Am J Physiol. 1991 Dec;261(6 Pt 2):F1071-9. DMV8APG RU https://pubmed.ncbi.nlm.nih.gov/1721495 DMHD3R8 DI DMHD3R8 DMHD3R8 DN D-4476 DMHD3R8 MI TTFQEMX DMHD3R8 MN Casein kinase I alpha (CSNK1A1) DMHD3R8 MT DTT DMHD3R8 MA Inhibitor DMHD3R8 RN Discovery of N6-phenyl-1H-pyrazolo[3,4-d]pyrimidine-3,6-diamine derivatives as novel CK1 inhibitors using common-feature pharmacophore model based virtual screening and hit-to-lead optimization. Eur J Med Chem. 2012 Oct;56:30-8. DMHD3R8 RU https://pubmed.ncbi.nlm.nih.gov/22944772 DMHD3R8 DI DMHD3R8 DMHD3R8 DN D-4476 DMHD3R8 MI TTH30UI DMHD3R8 MN Casein kinase I delta (CSNK1D) DMHD3R8 MT DTT DMHD3R8 MA Inhibitor DMHD3R8 RN The selectivity of protein kinase inhibitors: a further update. Biochem J. 2007 Dec 15;408(3):297-315. DMHD3R8 RU https://pubmed.ncbi.nlm.nih.gov/17850214 DMUWRIF DI DMUWRIF DMUWRIF DN DAP-81 DMUWRIF MI TTIYVQP DMUWRIF MN Polo-like kinase 1 (PLK1) DMUWRIF MT DTT DMUWRIF MA Inhibitor DMUWRIF RN Polo-like kinase (PLK) inhibitors in preclinical and early clinical development in oncology. Oncologist. 2009 Jun;14(6):559-70. DMUWRIF RU https://pubmed.ncbi.nlm.nih.gov/19474163 DM8WTAZ DI DM8WTAZ DM8WTAZ DN Debio1453 DM8WTAZ MI TT9142J DM8WTAZ MN Neisseria gonorrhoeae Enoyl-[acyl-carrier-protein] reductase (Neisseria fabI) DM8WTAZ MT DTT DM8WTAZ MA Inhibitor DM8WTAZ RN Clinical pipeline report, company report or official report of Debiopharm. DM8WTAZ RU https://www.debiopharm.com/drug-development/pipeline/debio-1453/ DMAUILH DI DMAUILH DMAUILH DN DecRVKRCMK DMAUILH MI TTH9WF6 DMAUILH MN Dibasic-processing enzyme (Furin) DMAUILH MT DTT DMAUILH MA Inhibitor DMAUILH RN Decanoyl-Arg-Val-Lys-Arg-Chloromethylketone: An Antiviral Compound That Acts against Flaviviruses through the Inhibition of Furin-Mediated prM Cleavage. Viruses. 2019 Oct 31;11(11):1011. DMAUILH RU https://pubmed.ncbi.nlm.nih.gov/31683742 DMJKQFT DI DMJKQFT DMJKQFT DN Dec-RVKR-CMK DMJKQFT MI TTUD6MS DMJKQFT MN HUMAN dibasic-processing enzyme (Furin) DMJKQFT MT DTT DMJKQFT MA Blocker DMJKQFT RN Coronaviruses - drug discovery and therapeutic options. Nat Rev Drug Discov. 2016 May;15(5):327-47. DMJKQFT RU https://pubmed.ncbi.nlm.nih.gov/26868298 DMD0T1U DI DMD0T1U DMD0T1U DN Depudecin DMD0T1U MI TT6R7JZ DMD0T1U MN Histone deacetylase 1 (HDAC1) DMD0T1U MT DTT DMD0T1U MA Inhibitor DMD0T1U RN Histone deacetylase inhibitors in cancer therapy: latest developments, trends and medicinal chemistry perspective. Anticancer Agents Med Chem. 2007 Sep;7(5):576-92. DMD0T1U RU https://pubmed.ncbi.nlm.nih.gov/17896917 DM2I76R DI DM2I76R DM2I76R DN Desmethylsertraline DM2I76R MI DTUGYRD DM2I76R MN P-glycoprotein 1 (ABCB1) DM2I76R MT DTP DM2I76R MA Substrate DM2I76R RN Sertraline and its metabolite desmethylsertraline, but not bupropion or its three major metabolites, have high affinity for P-glycoprotein. Biol Pharm Bull. 2008 Feb;31(2):231-4. DM2I76R RU https://doi.org/10.1248/bpb.31.231 DM5H2W9 DI DM5H2W9 DM5H2W9 DN Dioscin DM5H2W9 MI TT1UCIJ DM5H2W9 MN C-X-C chemokine receptor type 3 (CXCR3) DM5H2W9 MT DTT DM5H2W9 MA Antagonist DM5H2W9 RN Discovery of structurally diverse natural product antagonists of chemokine receptor CXCR3. Mol Divers. 2005;9(1-3):123-9. DM5H2W9 RU https://pubmed.ncbi.nlm.nih.gov/15789559 DMA2K7C DI DMA2K7C DMA2K7C DN Donitriptan DMA2K7C MI TTK8CXU DMA2K7C MN 5-HT 1B receptor (HTR1B) DMA2K7C MT DTT DMA2K7C MA Modulator DMA2K7C RN Donitriptan, but not sumatriptan, inhibits capsaicin-induced canine external carotid vasodilatation via 5-HT1B rather than 5-HT1D receptors.Br J Pharmacol.2006 Sep;149(1):82-91. DMA2K7C RU https://www.ncbi.nlm.nih.gov/pubmed/16880765 DMA2K7C DI DMA2K7C DMA2K7C DN Donitriptan DMA2K7C MI TT6MSOK DMA2K7C MN 5-HT 1D receptor (HTR1D) DMA2K7C MT DTT DMA2K7C MA Modulator DMA2K7C RN Donitriptan, but not sumatriptan, inhibits capsaicin-induced canine external carotid vasodilatation via 5-HT1B rather than 5-HT1D receptors.Br J Pharmacol.2006 Sep;149(1):82-91. DMA2K7C RU https://www.ncbi.nlm.nih.gov/pubmed/16880765 DMYH3VR DI DMYH3VR DMYH3VR DN DP-3975 DMYH3VR MI TTZPY6J DMYH3VR MN Tyrosine-protein kinase UFO (AXL) DMYH3VR MT DTT DMYH3VR MA Inhibitor DMYH3VR RN AXL receptor tyrosine kinase as a promising anti-cancer approach: functions, molecular mechanisms and clinical applications. Mol Cancer. 2019 Nov 4;18(1):153. DMYH3VR RU https://pubmed.ncbi.nlm.nih.gov/31684958 DMMI2EY DI DMMI2EY DMMI2EY DN DS-1558 DMMI2EY MI TTB8FUC DMMI2EY MN Free fatty acid receptor 1 (GPR40) DMMI2EY MT DTT DMMI2EY MA Agonist DMMI2EY RN Discovery of DS-1558: A Potent and Orally Bioavailable GPR40 Agonist. ACS Med Chem Lett. 2015 Jan 13;6(3):266-70. DMMI2EY RU https://pubmed.ncbi.nlm.nih.gov/25815144 DM8YSW7 DI DM8YSW7 DM8YSW7 DN DX-2802 DM8YSW7 MI TT6X50U DM8YSW7 MN Matrix metalloproteinase-9 (MMP-9) DM8YSW7 MT DTT DM8YSW7 RN Clinical pipeline report, company report or official report of DeepDyve. DM8YSW7 RU https://www.deepdyve.com/lp/elsevier/490-mmp-9-as-a-stromal-target-in-cancer-pzh95qPjis DMCVXBE DI DMCVXBE DMCVXBE DN E-64D DMCVXBE MI TTS586L DMCVXBE MN HUMAN cathepsin L (CTSL) DMCVXBE MT DTT DMCVXBE MA Blocker DMCVXBE RN Coronaviruses - drug discovery and therapeutic options. Nat Rev Drug Discov. 2016 May;15(5):327-47. DMCVXBE RU https://pubmed.ncbi.nlm.nih.gov/26868298 DMG4DHX DI DMG4DHX DMG4DHX DN ED-1812 DMG4DHX MI TT9IK2Z DMG4DHX MN N-methyl-D-aspartate receptor (NMDAR) DMG4DHX MT DTT DMG4DHX MA Antagonist DMG4DHX RN WO patent application no. 2009,0164,86, Use of nmda receptor antagonists for treatment of urologic tumors. DMG4DHX RU http://worldwide.espacenet.com/publicationDetails/biblio?DB=worldwide.espacenet.com&II=0&ND=3&adjacent=true&locale=en_EP&FT=D&date=20090205&CC=WO&NR=2009016486A2&KC=A2 DMELPJM DI DMELPJM DMELPJM DN EDD7H9 DMELPJM MI TTDYP7I DMELPJM MN Sphingosine-1-phosphate receptor 3 (S1PR3) DMELPJM MT DTT DMELPJM RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 277). DMELPJM RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=277 DMZ3YP6 DI DMZ3YP6 DMZ3YP6 DN EGFR/IGFR tandem adnectin DMZ3YP6 MI TTGKNB4 DMZ3YP6 MN Epidermal growth factor receptor (EGFR) DMZ3YP6 MT DTT DMZ3YP6 MA Inhibitor DMZ3YP6 RN Clinical pipeline report, company report or official report of Bristol-Myers Squibb. DMZ3YP6 RU http://news.bms.com/press-release/rd-news/bristol-myers-squibb-announces-collaboration-evaluate-opdivo-nivolumab-combina DMZ3YP6 DI DMZ3YP6 DMZ3YP6 DN EGFR/IGFR tandem adnectin DMZ3YP6 MI TTHRID2 DMZ3YP6 MN Insulin-like growth factor I receptor (IGF1R) DMZ3YP6 MT DTT DMZ3YP6 MA Inhibitor DMZ3YP6 RN Clinical pipeline report, company report or official report of Bristol-Myers Squibb. DMZ3YP6 RU http://news.bms.com/press-release/rd-news/bristol-myers-squibb-announces-collaboration-evaluate-opdivo-nivolumab-combina DMK6WIO DI DMK6WIO DMK6WIO DN Enrofloxacin DMK6WIO MI DTI7UX6 DMK6WIO MN Breast cancer resistance protein (ABCG2) DMK6WIO MT DTP DMK6WIO MA Substrate DMK6WIO RN Interaction of enrofloxacin with breast cancer resistance protein (BCRP/ABCG2): influence of flavonoids and role in milk secretion in sheep. J Vet Pharmacol Ther. 2006 Aug;29(4):279-87. DMK6WIO RU https://doi.org/10.1111/j.1365-2885.2006.00744.x DM2K51E DI DM2K51E DM2K51E DN EP-01492 DM2K51E MI TTWDC17 DM2K51E MN Growth hormone secretagogue receptor 1 (GHSR) DM2K51E MT DTT DM2K51E MA Antagonist DM2K51E RN Emerging drugs for obesity: linking novel biological mechanisms to pharmaceutical pipelines. Expert Opin Emerg Drugs. 2005 Aug;10(3):643-60. DM2K51E RU https://pubmed.ncbi.nlm.nih.gov/16083333 DMJEKQM DI DMJEKQM DMJEKQM DN EP-128504 DMJEKQM MI TTPNE41 DMJEKQM MN CI Man-6-P receptor (IGF2R) DMJEKQM MT DTT DMJEKQM MA Modulator DMJEKQM RN The discovery and mechanism of action of novel tumor-selective and apoptosis-inducing 3,5-diaryl-1,2,4-oxadiazole series using a chemical genetics approach. Mol Cancer Ther. 2005 May;4(5):761-71. DMJEKQM RU https://pubmed.ncbi.nlm.nih.gov/15897240 DMERKYO DI DMERKYO DMERKYO DN EP-2167 DMERKYO MI TTV5YEH DMERKYO MN Transferrin (TF) DMERKYO MT DTT DMERKYO MA Inducer DMERKYO RN Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800017941) DMERKYO RU http://adisinsight.springer.com/drugs/800017941 DMVNR20 DI DMVNR20 DMVNR20 DN Epipodophyllotoxins DMVNR20 MI DTQ3ZHF DMVNR20 MN Multidrug resistance-associated protein 3 (ABCC3) DMVNR20 MT DTP DMVNR20 MA Substrate DMVNR20 RN Characterization of drug transport by the human multidrug resistance protein 3 (ABCC3). J Biol Chem. 2001 Dec 7;276(49):46400-7. DMVNR20 RU http://www.ncbi.nlm.nih.gov/pubmed/11581266 DMVNR20 DI DMVNR20 DMVNR20 DN Epipodophyllotoxins DMVNR20 MI DT582KR DMVNR20 MN Multidrug resistance-associated protein 6 (ABCC6) DMVNR20 MT DTP DMVNR20 MA Substrate DMVNR20 RN Characterization of the drug resistance and transport properties of multidrug resistance protein 6 (MRP6, ABCC6). Cancer Res. 2002 Nov 1;62(21):6172-7. DMVNR20 RU http://www.ncbi.nlm.nih.gov/pubmed/12414644 DM5K17C DI DM5K17C DM5K17C DN EPL-1410 DM5K17C MI TTZJYKH DM5K17C MN Indoleamine 2,3-dioxygenase 1 (IDO1) DM5K17C MT DTT DM5K17C MA Inhibitor DM5K17C RN Tryptophan metabolism as a common therapeutic target in cancer, neurodegeneration and beyond. Nat Rev Drug Discov. 2019 May;18(5):379-401. DM5K17C RU https://pubmed.ncbi.nlm.nih.gov/30760888 DM5K17C DI DM5K17C DM5K17C DN EPL-1410 DM5K17C MI TTXNCBV DM5K17C MN Tryptophan 2,3-dioxygenase (TDO) DM5K17C MT DTT DM5K17C MA Inhibitor DM5K17C RN Tryptophan metabolism as a common therapeutic target in cancer, neurodegeneration and beyond. Nat Rev Drug Discov. 2019 May;18(5):379-401. DM5K17C RU https://pubmed.ncbi.nlm.nih.gov/30760888 DMX2FZS DI DMX2FZS DMX2FZS DN Epothilone A DMX2FZS MI DTUGYRD DMX2FZS MN P-glycoprotein 1 (ABCB1) DMX2FZS MT DTP DMX2FZS MA Substrate DMX2FZS RN Human intestinal transporter database: QSAR modeling and virtual profiling of drug uptake, efflux and interactions. Pharm Res. 2013 Apr;30(4):996-1007. DMX2FZS RU https://doi.org/10.1007/s11095-012-0935-x DM2TESM DI DM2TESM DM2TESM DN EPZ028862 DM2TESM MI TTKLJYX DM2TESM MN Histone-lysine N-methyltransferase SMYD3 (SMYD3) DM2TESM MT DTT DM2TESM MA Inhibitor DM2TESM RN Epigenetics and beyond: targeting writers of protein lysine methylation to treat disease. Nat Rev Drug Discov. 2021 Apr;20(4):265-286. DM2TESM RU https://pubmed.ncbi.nlm.nih.gov/33469207 DM8UKL0 DI DM8UKL0 DM8UKL0 DN EPZ031686 DM8UKL0 MI TTKLJYX DM8UKL0 MN Histone-lysine N-methyltransferase SMYD3 (SMYD3) DM8UKL0 MT DTT DM8UKL0 MA Inhibitor DM8UKL0 RN Therapeutical potential of deregulated lysine methyltransferase SMYD3 as a safe target for novel anticancer agents. Expert Opin Ther Targets. 2017 Feb;21(2):145-157. DM8UKL0 RU https://pubmed.ncbi.nlm.nih.gov/28019723 DMHU742 DI DMHU742 DMHU742 DN EPZ032597 DMHU742 MI TT7YJFO DMHU742 MN SET and MYND domain-containing protein 2 (SMYD2) DMHU742 MT DTT DMHU742 MA Inhibitor DMHU742 RN Epigenetics and beyond: targeting writers of protein lysine methylation to treat disease. Nat Rev Drug Discov. 2021 Apr;20(4):265-286. DMHU742 RU https://pubmed.ncbi.nlm.nih.gov/33469207 DMUKVYL DI DMUKVYL DMUKVYL DN EPZ0330456 DMUKVYL MI TTKLJYX DMUKVYL MN Histone-lysine N-methyltransferase SMYD3 (SMYD3) DMUKVYL MT DTT DMUKVYL MA Inhibitor DMUKVYL RN Epigenetics and beyond: targeting writers of protein lysine methylation to treat disease. Nat Rev Drug Discov. 2021 Apr;20(4):265-286. DMUKVYL RU https://pubmed.ncbi.nlm.nih.gov/33469207 DMDO6NZ DI DMDO6NZ DMDO6NZ DN EPZ033294 DMDO6NZ MI TT7YJFO DMDO6NZ MN SET and MYND domain-containing protein 2 (SMYD2) DMDO6NZ MT DTT DMDO6NZ MA Inhibitor DMDO6NZ RN Epigenetics and beyond: targeting writers of protein lysine methylation to treat disease. Nat Rev Drug Discov. 2021 Apr;20(4):265-286. DMDO6NZ RU https://pubmed.ncbi.nlm.nih.gov/33469207 DMBINP0 DI DMBINP0 DMBINP0 DN ER-319711-15 DMBINP0 MI TTDIGC1 DMBINP0 MN Dipeptidyl peptidase 4 (DPP-4) DMBINP0 MT DTT DMBINP0 MA Inhibitor DMBINP0 RN Emerging drug candidates of dipeptidyl peptidase IV (DPP IV) inhibitor class for the treatment of Type 2 Diabetes. Curr Drug Targets. 2009 Jan;10(1):71-87. DMBINP0 RU https://pubmed.ncbi.nlm.nih.gov/19149538 DMUFP05 DI DMUFP05 DMUFP05 DN F-15063 DMUFP05 MI TTEX248 DMUFP05 MN Dopamine D2 receptor (D2R) DMUFP05 MT DTT DMUFP05 MA Modulator DMUFP05 RN F15063, a potential antipsychotic with dopamine D(2)/D(3) antagonist, 5-HT(1A) agonist and D(4) partial agonist properties: (IV) duration of brain D2-like receptor occupancy and antipsychotic-like activity versus plasma concentration in mice.Naunyn Schmiedebergs Arch Pharmacol.2007 Jun;375(4):241-50. DMUFP05 RU https://www.ncbi.nlm.nih.gov/pubmed/17453175 DMUFP05 DI DMUFP05 DMUFP05 DN F-15063 DMUFP05 MI TT4C8EA DMUFP05 MN Dopamine D3 receptor (D3R) DMUFP05 MT DTT DMUFP05 MA Modulator DMUFP05 RN F15063, a potential antipsychotic with dopamine D(2)/D(3) antagonist, 5-HT(1A) agonist and D(4) partial agonist properties: (IV) duration of brain D2-like receptor occupancy and antipsychotic-like activity versus plasma concentration in mice.Naunyn Schmiedebergs Arch Pharmacol.2007 Jun;375(4):241-50. DMUFP05 RU https://www.ncbi.nlm.nih.gov/pubmed/17453175 DM29M4R DI DM29M4R DM29M4R DN F24F2 DM29M4R MI TTM0O8B DM29M4R MN Bacillus poly-gamma-d-glutamic acid (Bacillus PGA) DM29M4R MT DTT DM29M4R RN Protective and immunochemical activities of monoclonal antibodies reactive with the Bacillus anthracis polypeptide capsule. Infect Immun. 2007 Jan;75(1):152-63. DM29M4R RU https://pubmed.ncbi.nlm.nih.gov/17060470 DM2GEHA DI DM2GEHA DM2GEHA DN F26G3 DM2GEHA MI TTM0O8B DM2GEHA MN Bacillus poly-gamma-d-glutamic acid (Bacillus PGA) DM2GEHA MT DTT DM2GEHA RN Protective and immunochemical activities of monoclonal antibodies reactive with the Bacillus anthracis polypeptide capsule. Infect Immun. 2007 Jan;75(1):152-63. DM2GEHA RU https://pubmed.ncbi.nlm.nih.gov/17060470 DMAVQ2X DI DMAVQ2X DMAVQ2X DN F26G4 DMAVQ2X MI TTM0O8B DMAVQ2X MN Bacillus poly-gamma-d-glutamic acid (Bacillus PGA) DMAVQ2X MT DTT DMAVQ2X RN Protective and immunochemical activities of monoclonal antibodies reactive with the Bacillus anthracis polypeptide capsule. Infect Immun. 2007 Jan;75(1):152-63. DMAVQ2X RU https://pubmed.ncbi.nlm.nih.gov/17060470 DMTHLB8 DI DMTHLB8 DMTHLB8 DN FA-613 DMTHLB8 MI TT3UY29 DMTHLB8 MN HUMAN dihydroorotate dehydrogenase (DHODH) DMTHLB8 MT DTT DMTHLB8 MA Inhibitor DMTHLB8 RN Broad-spectrum inhibition of common respiratory RNA viruses by a pyrimidine synthesis inhibitor with involvement of the host antiviral response. J Gen Virol. 2017 May;98(5):946-954. DMTHLB8 RU https://pubmed.ncbi.nlm.nih.gov/28555543 DMYFVZ3 DI DMYFVZ3 DMYFVZ3 DN FAP5-DM1 DMYFVZ3 MI TTGPQ0F DMYFVZ3 MN Prolyl endopeptidase FAP (FAP) DMYFVZ3 MT DTT DMYFVZ3 RN Effective immunoconjugate therapy in cancer models targeting a serine protease of tumor fibroblasts. Clin Cancer Res. 2008 Jul 15;14(14):4584-92. DMYFVZ3 RU https://pubmed.ncbi.nlm.nih.gov/18628473 DMAX2EW DI DMAX2EW DMAX2EW DN FAS1 DMAX2EW MI TT7AOUD DMAX2EW MN Fatty acid synthase (FASN) DMAX2EW MT DTT DMAX2EW MA Inhibitor DMAX2EW RN Novel antifungal agents, targets or therapeutic strategies for the treatment of invasive fungal diseases: a review of the literature (2005-2009). Rev Iberoam Micol. 2009 Mar 31;26(1):15-22. DMAX2EW RU https://pubmed.ncbi.nlm.nih.gov/19463273 DMBZVYG DI DMBZVYG DMBZVYG DN FOXO4-DRI DMBZVYG MI TTKW9CI DMBZVYG MN FOXO4-P53 interaction (FOXO4-P53 PPI) DMBZVYG MT DTT DMBZVYG MA Antagonist DMBZVYG RN FOXO4-DRI alleviates age-related testosterone secretion insufficiency by targeting senescent Leydig cells in aged mice. Aging (Albany NY). 2020 Jan 20;12(2):1272-1284. DMBZVYG RU https://pubmed.ncbi.nlm.nih.gov/31959736 DMUHVEA DI DMUHVEA DMUHVEA DN FPL-14294 DMUHVEA MI TTCG0AL DMUHVEA MN Cholecystokinin receptor type A (CCKAR) DMUHVEA MT DTT DMUHVEA MA Agonist DMUHVEA RN Emerging drugs for obesity: linking novel biological mechanisms to pharmaceutical pipelines. Expert Opin Emerg Drugs. 2005 Aug;10(3):643-60. DMUHVEA RU https://pubmed.ncbi.nlm.nih.gov/16083333 DMF53Z7 DI DMF53Z7 DMF53Z7 DN FR167356 DMF53Z7 MI TTTK3BH DMF53Z7 MN Vacuolar-type proton ATPase (v-ATPase) DMF53Z7 MT DTT DMF53Z7 MA Inhibitor DMF53Z7 RN Therapeutic target database update 2012: a resource for facilitating target-oriented drug discovery. Nucleic Acids Res. 2012 Jan;40(Database issue):D1128-36. DMF53Z7 RU https://pubmed.ncbi.nlm.nih.gov/21948793 DMXR287 DI DMXR287 DMXR287 DN FR-79620 DMXR287 MI TTY6EWA DMXR287 MN Neuropeptide Y receptor type 5 (NPY5R) DMXR287 MT DTT DMXR287 MA Antagonist DMXR287 RN Emerging drugs for obesity: linking novel biological mechanisms to pharmaceutical pipelines. Expert Opin Emerg Drugs. 2005 Aug;10(3):643-60. DMXR287 RU https://pubmed.ncbi.nlm.nih.gov/16083333 DMLNRCI DI DMLNRCI DMLNRCI DN FSA2 DMLNRCI MI TT7AOUD DMLNRCI MN Fatty acid synthase (FASN) DMLNRCI MT DTT DMLNRCI MA Inhibitor DMLNRCI RN Novel antifungal agents, targets or therapeutic strategies for the treatment of invasive fungal diseases: a review of the literature (2005-2009). Rev Iberoam Micol. 2009 Mar 31;26(1):15-22. DMLNRCI RU https://pubmed.ncbi.nlm.nih.gov/19463273 DMXE6ML DI DMXE6ML DMXE6ML DN FX-007 DMXE6ML MI TTTDVOJ DMXE6ML MN Tropomyosin-related kinase A (TrkA) DMXE6ML MT DTT DMXE6ML MA Inhibitor DMXE6ML RN Preclinical trail of FX007 for treating osteoarthritis. Flexion Therapeutics Inc. DMXE6ML RU http://www.biocentury.com/products/fx007 DM7UJ1I DI DM7UJ1I DM7UJ1I DN FX-107 DM7UJ1I MI TTWODQF DM7UJ1I MN Fibrin (FG) DM7UJ1I MT DTT DM7UJ1I MA Inhibitor DM7UJ1I RN FX-06, a fibrin-derived Bbeta15-42 peptide for the potential treatment of reperfusion injury following myocardial infarction. Curr Opin Investig Drugs. 2009 Sep;10(9):997-1003. DM7UJ1I RU https://pubmed.ncbi.nlm.nih.gov/19705343 DMR1CLY DI DMR1CLY DMR1CLY DN GC376 DMR1CLY MI TT1D53B DMR1CLY MN COVID-19 3C-like protease (3CLpro) DMR1CLY MT DTT DMR1CLY MA Inhibitor DMR1CLY RN Boceprevir, GC-376, and calpain inhibitors II, XII inhibit SARS-CoV-2 viral replication by targeting the viral main protease. 2020. April 20. doi: https://doi.org/10.1101/2020.04.20.051581 DMR1CLY RU https://www.biorxiv.org/content/10.1101/2020.04.20.051581v1 DMR1CLY DI DMR1CLY DMR1CLY DN GC376 DMR1CLY MI TTWOH4Q DMR1CLY MN MERS-CoV 3C-like proteinase (3CLpro) DMR1CLY MT DTT DMR1CLY MA Inhibitor DMR1CLY RN Reversal of the Progression of Fatal Coronavirus Infection in Cats by a Broad-Spectrum Coronavirus Protease Inhibitor. PLoS Pathog. 2016 Mar 30;12(3):e1005531. DMR1CLY RU https://pubmed.ncbi.nlm.nih.gov/27027316 DMR1CLY DI DMR1CLY DMR1CLY DN GC376 DMR1CLY MI TTPZG3C DMR1CLY MN SARS-CoV 3C-like protease (3CLpro) DMR1CLY MT DTT DMR1CLY MA Inhibitor DMR1CLY RN Reversal of the Progression of Fatal Coronavirus Infection in Cats by a Broad-Spectrum Coronavirus Protease Inhibitor. PLoS Pathog. 2016 Mar 30;12(3):e1005531. DMR1CLY RU https://pubmed.ncbi.nlm.nih.gov/27027316 DM7PBJC DI DM7PBJC DM7PBJC DN GC813 DM7PBJC MI TTWOH4Q DM7PBJC MN MERS-CoV 3C-like proteinase (3CLpro) DM7PBJC MT DTT DM7PBJC MA Inhibitor DM7PBJC RN Structure-guided Design of Potent and Permeable Inhibitors of MERS Coronavirus 3CL Protease That Utilize a Piperidine Moiety as a Novel Design Element Eur J Med Chem. 2018 Apr 25;150:334-346. DM7PBJC RU https://pubmed.ncbi.nlm.nih.gov/29544147 DMFW0H9 DI DMFW0H9 DMFW0H9 DN GCR-1087 DMFW0H9 MI TTMXGCW DMFW0H9 MN Adrenergic receptor beta-3 (ADRB3) DMFW0H9 MT DTT DMFW0H9 MA Agonist DMFW0H9 RN Emerging drugs for obesity: linking novel biological mechanisms to pharmaceutical pipelines. Expert Opin Emerg Drugs. 2005 Aug;10(3):643-60. DMFW0H9 RU https://pubmed.ncbi.nlm.nih.gov/16083333 DMFQI38 DI DMFQI38 DMFQI38 DN GG-8573 DMFQI38 MI TTCG0AL DMFQI38 MN Cholecystokinin receptor type A (CCKAR) DMFQI38 MT DTT DMFQI38 MA Agonist DMFQI38 RN Emerging drugs for obesity: linking novel biological mechanisms to pharmaceutical pipelines. Expert Opin Emerg Drugs. 2005 Aug;10(3):643-60. DMFQI38 RU https://pubmed.ncbi.nlm.nih.gov/16083333 DMFQI38 DI DMFQI38 DMFQI38 DN GG-8573 DMFQI38 MI TTVFO0U DMFQI38 MN Gastrin/cholecystokinin type B receptor (CCKBR) DMFQI38 MT DTT DMFQI38 MA Antagonist DMFQI38 RN Emerging drugs for obesity: linking novel biological mechanisms to pharmaceutical pipelines. Expert Opin Emerg Drugs. 2005 Aug;10(3):643-60. DMFQI38 RU https://pubmed.ncbi.nlm.nih.gov/16083333 DM25N8B DI DM25N8B DM25N8B DN GI-264879A DM25N8B MI TTRK9JT DM25N8B MN Neuropeptide Y receptor type 1 (NPY1R) DM25N8B MT DTT DM25N8B MA Antagonist DM25N8B RN Emerging drugs for obesity: linking novel biological mechanisms to pharmaceutical pipelines. Expert Opin Emerg Drugs. 2005 Aug;10(3):643-60. DM25N8B RU https://pubmed.ncbi.nlm.nih.gov/16083333 DMZC91G DI DMZC91G DMZC91G DN GL21.T DMZC91G MI TTZPY6J DMZC91G MN Tyrosine-protein kinase UFO (AXL) DMZC91G MT DTT DMZC91G RN AXL receptor tyrosine kinase as a promising anti-cancer approach: functions, molecular mechanisms and clinical applications. Mol Cancer. 2019 Nov 4;18(1):153. DMZC91G RU https://pubmed.ncbi.nlm.nih.gov/31684958 DMSW07R DI DMSW07R DMSW07R DN GLPG-0492 DMSW07R MI TTS64P2 DMSW07R MN Androgen receptor (AR) DMSW07R MT DTT DMSW07R MA Modulator DMSW07R RN GLPG0492, a novel selective androgen receptor modulator, improves muscle performance in the exercised-mdx mouse model of muscular dystrophy. Pharmacol Res. 2013 Jun;72:9-24. DMSW07R RU https://pubmed.ncbi.nlm.nih.gov/23523664 DMXVHOQ DI DMXVHOQ DMXVHOQ DN GNE684 DMXVHOQ MI TTAIQSN DMXVHOQ MN Receptor-interacting protein 1 (RIPK1) DMXVHOQ MT DTT DMXVHOQ MA Inhibitor DMXVHOQ RN Impaired RIPK1 ubiquitination sensitizes mice to TNF toxicity and inflammatory cell death. Cell Death Differ. 2021 Mar;28(3):985-1000. DMXVHOQ RU https://pubmed.ncbi.nlm.nih.gov/32999468 DMTJRLU DI DMTJRLU DMTJRLU DN GNTI DMTJRLU MI TTQW87Y DMTJRLU MN Opioid receptor kappa (OPRK1) DMTJRLU MT DTT DMTJRLU MA Antagonist DMTJRLU RN Emerging drugs for obesity: linking novel biological mechanisms to pharmaceutical pipelines. Expert Opin Emerg Drugs. 2005 Aug;10(3):643-60. DMTJRLU RU https://pubmed.ncbi.nlm.nih.gov/16083333 DMTJRLU DI DMTJRLU DMTJRLU DN GNTI DMTJRLU MI TTKWM86 DMTJRLU MN Opioid receptor mu (MOP) DMTJRLU MT DTT DMTJRLU MA Antagonist DMTJRLU RN Emerging drugs for obesity: linking novel biological mechanisms to pharmaceutical pipelines. Expert Opin Emerg Drugs. 2005 Aug;10(3):643-60. DMTJRLU RU https://pubmed.ncbi.nlm.nih.gov/16083333 DMNZA4L DI DMNZA4L DMNZA4L DN Griffithsin DMNZA4L MI TTTL19V DMNZA4L MN SARS-CoV spike glycoprotein (S) DMNZA4L MT DTT DMNZA4L MA Blocker DMNZA4L RN Coronaviruses - drug discovery and therapeutic options. Nat Rev Drug Discov. 2016 May;15(5):327-47. DMNZA4L RU https://pubmed.ncbi.nlm.nih.gov/26868298 DM19T2V DI DM19T2V DM19T2V DN GRL001 DM19T2V MI TT1D53B DM19T2V MN COVID-19 3C-like protease (3CLpro) DM19T2V MT DTT DM19T2V MA Inhibitor DM19T2V RN Coronaviruses - drug discovery and therapeutic options. Nat Rev Drug Discov. 2016 May;15(5):327-47. DM19T2V RU https://pubmed.ncbi.nlm.nih.gov/26868298 DMVB1PD DI DMVB1PD DMVB1PD DN GRL-001 DMVB1PD MI TTWOH4Q DMVB1PD MN MERS-CoV 3C-like proteinase (3CLpro) DMVB1PD MT DTT DMVB1PD MA Inhibitor DMVB1PD RN Coronaviruses - drug discovery and therapeutic options. Nat Rev Drug Discov. 2016 May;15(5):327-47. DMVB1PD RU https://pubmed.ncbi.nlm.nih.gov/26868298 DMVB1PD DI DMVB1PD DMVB1PD DN GRL-001 DMVB1PD MI TTPZG3C DMVB1PD MN SARS-CoV 3C-like protease (3CLpro) DMVB1PD MT DTT DMVB1PD MA Inhibitor DMVB1PD RN Coronaviruses - drug discovery and therapeutic options. Nat Rev Drug Discov. 2016 May;15(5):327-47. DMVB1PD RU https://pubmed.ncbi.nlm.nih.gov/26868298 DMX9AGF DI DMX9AGF DMX9AGF DN GRL0617 DMX9AGF MI TTNHMO8 DMX9AGF MN COVID-19 papain-like proteinase (PL-PRO) DMX9AGF MT DTT DMX9AGF MA Inhibitor DMX9AGF RN Crystal structure of SARS-CoV-2 papain-like protease. Acta Pharm Sin B. 2021 Jan;11(1):237-245. DMX9AGF RU https://pubmed.ncbi.nlm.nih.gov/32895623 DMNU3SI DI DMNU3SI DMNU3SI DN GSK180 DMNU3SI MI TTIY56R DMNU3SI MN Kynurenine 3-hydroxylase (KMO) DMNU3SI MT DTT DMNU3SI MA Inhibitor DMNU3SI RN Tryptophan metabolism as a common therapeutic target in cancer, neurodegeneration and beyond. Nat Rev Drug Discov. 2019 May;18(5):379-401. DMNU3SI RU https://pubmed.ncbi.nlm.nih.gov/30760888 DM5AOI3 DI DM5AOI3 DM5AOI3 DN GSK2643943A DM5AOI3 MI TT07QDI DM5AOI3 MN Ubiquitin carboxyl-terminal hydrolase 20 (USP20) DM5AOI3 MT DTT DM5AOI3 MA Inhibitor DM5AOI3 RN Deubiquitylating enzymes and drug discovery: emerging opportunities. Nat Rev Drug Discov. 2018 Jan;17(1):57-78. DM5AOI3 RU https://pubmed.ncbi.nlm.nih.gov/28959952 DMAZROV DI DMAZROV DMAZROV DN GSK2807 DMAZROV MI TTKLJYX DMAZROV MN Histone-lysine N-methyltransferase SMYD3 (SMYD3) DMAZROV MT DTT DMAZROV MA Inhibitor DMAZROV RN Structure-Based Design of a Novel SMYD3 Inhibitor that Bridges the SAM-and MEKK2-Binding Pockets. Structure. 2016 May 3;24(5):774-781. DMAZROV RU https://pubmed.ncbi.nlm.nih.gov/27066749 DMFJ0ZA DI DMFJ0ZA DMFJ0ZA DN GSK-326416 DMFJ0ZA MI TT953CX DMFJ0ZA MN Motilin receptor (MLNR) DMFJ0ZA MT DTT DMFJ0ZA MA Agonist DMFJ0ZA RN Emerging drugs for postoperative ileus. Expert Opin Emerg Drugs. 2007 Nov;12(4):619-26. DMFJ0ZA RU https://pubmed.ncbi.nlm.nih.gov/17979603 DM04UGQ DI DM04UGQ DM04UGQ DN GSK366 DM04UGQ MI TTIY56R DM04UGQ MN Kynurenine 3-hydroxylase (KMO) DM04UGQ MT DTT DM04UGQ MA Inhibitor DM04UGQ RN Structural and mechanistic basis of differentiated inhibitors of the acute pancreatitis target kynurenine-3-monooxygenase. Nat Commun. 2017 Jun 12;8:15827. DM04UGQ RU https://pubmed.ncbi.nlm.nih.gov/28604669 DM1S5UO DI DM1S5UO DM1S5UO DN GSK4112 DM1S5UO MI TTAD1O8 DM1S5UO MN V-erbA-related protein 1 (NR1D1) DM1S5UO MT DTT DM1S5UO MA Agonist DM1S5UO RN Identification of SR8278, a synthetic antagonist of the nuclear heme receptor REV-ERB. ACS Chem Biol. 2011 Feb 18;6(2):131-4. DM1S5UO RU https://pubmed.ncbi.nlm.nih.gov/21043485 DMNAT5V DI DMNAT5V DMNAT5V DN GW-2592X DMNAT5V MI TTDZN01 DMNAT5V MN Cathepsin K (CTSK) DMNAT5V MT DTT DMNAT5V MA Inhibitor DMNAT5V RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2350). DMNAT5V RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2350 DM3PMAZ DI DM3PMAZ DM3PMAZ DN GW-3333 DM3PMAZ MI TTDU0HP DM3PMAZ MN Bacterial Cystathionine gamma-synthase (Bact metB) DM3PMAZ MT DTT DM3PMAZ MA Inhibitor DM3PMAZ RN Crystal structures of cystathionine gamma-synthase inhibitor complexes rationalize the increased affinity of a novel inhibitor. J Mol Biol. 2001 Aug 24;311(4):789-801. DM3PMAZ RU https://pubmed.ncbi.nlm.nih.gov/11518531 DM3PMAZ DI DM3PMAZ DM3PMAZ DN GW-3333 DM3PMAZ MI TT6AZXG DM3PMAZ MN TNF alpha converting enzyme (ADAM17) DM3PMAZ MT DTT DM3PMAZ MA Inhibitor DM3PMAZ RN Emerging drugs for the treatment of chronic obstructive pulmonary disease. Expert Opin Emerg Drugs. 2006 May;11(2):275-91. DM3PMAZ RU https://pubmed.ncbi.nlm.nih.gov/16634702 DMHUD27 DI DMHUD27 DMHUD27 DN GW-594884A DMHUD27 MI TTY6EWA DMHUD27 MN Neuropeptide Y receptor type 5 (NPY5R) DMHUD27 MT DTT DMHUD27 MA Antagonist DMHUD27 RN Emerging drugs for obesity: linking novel biological mechanisms to pharmaceutical pipelines. Expert Opin Emerg Drugs. 2005 Aug;10(3):643-60. DMHUD27 RU https://pubmed.ncbi.nlm.nih.gov/16083333 DM97RV4 DI DM97RV4 DM97RV4 DN GYKI-47261 DM97RV4 MI TTAN6JD DM97RV4 MN Glutamate receptor AMPA (GRIA) DM97RV4 MT DTT DM97RV4 MA Antagonist DM97RV4 RN Drugs used to treat Parkinson's disease, present status and future directions. CNS Neurol Disord Drug Targets. 2008 Oct;7(4):321-42. DM97RV4 RU https://pubmed.ncbi.nlm.nih.gov/18991661 DM6GSI1 DI DM6GSI1 DM6GSI1 DN HBX19818 DM6GSI1 MI TTXU3EQ DM6GSI1 MN Herpesvirus ubiquitin-specific protease (HAUSP) DM6GSI1 MT DTT DM6GSI1 MA Inhibitor DM6GSI1 RN Small-molecule inhibitor of USP7/HAUSP ubiquitin protease stabilizes and activates p53 in cells. Mol Cancer Ther. 2009 Aug;8(8):2286-95. DM6GSI1 RU https://pubmed.ncbi.nlm.nih.gov/19671755 DMPLZ7E DI DMPLZ7E DMPLZ7E DN HC-Toxin DMPLZ7E MI TT6R7JZ DMPLZ7E MN Histone deacetylase 1 (HDAC1) DMPLZ7E MT DTT DMPLZ7E MA Inhibitor DMPLZ7E RN Histone deacetylase inhibitors in cancer therapy: latest developments, trends and medicinal chemistry perspective. Anticancer Agents Med Chem. 2007 Sep;7(5):576-92. DMPLZ7E RU https://pubmed.ncbi.nlm.nih.gov/17896917 DMLZ5TQ DI DMLZ5TQ DMLZ5TQ DN Hexamethylene amiloride DMLZ5TQ MI TTL3H2W DMLZ5TQ MN SARS-CoV envelope small membrane protein (E) DMLZ5TQ MT DTT DMLZ5TQ MA Inhibitor DMLZ5TQ RN Coronaviruses - drug discovery and therapeutic options. Nat Rev Drug Discov. 2016 May;15(5):327-47. DMLZ5TQ RU https://pubmed.ncbi.nlm.nih.gov/26868298 DMRE52S DI DMRE52S DMRE52S DN HL-004 DMRE52S MI TTMF541 DMRE52S MN Liver carboxylesterase (CES1) DMRE52S MT DTT DMRE52S MA Modulator DMRE52S RN ACAT inhibitor HL-004 accelerates the regression of hypercholesterolemia in stroke-prone spontaneously hypertensive rats (SHRSP): stimulation of bile acid production by HL-004. Atherosclerosis. 1997 Aug;133(1):97-104. DMRE52S RU https://pubmed.ncbi.nlm.nih.gov/9258412 DMBQDA3 DI DMBQDA3 DMBQDA3 DN Homocamptothecin DMBQDA3 MI DTI7UX6 DMBQDA3 MN Breast cancer resistance protein (ABCG2) DMBQDA3 MT DTP DMBQDA3 MA Substrate DMBQDA3 RN ABCG2: determining its relevance in clinical drug resistance. Cancer Metastasis Rev. 2007 Mar;26(1):39-57. DMBQDA3 RU http://www.ncbi.nlm.nih.gov/pubmed/17323127 DM69UZG DI DM69UZG DM69UZG DN HPP-851 DM69UZG MI TTN7BL9 DM69UZG MN Corticosteroid 11-beta-dehydrogenase 1 (HSD11B1) DM69UZG MT DTT DM69UZG MA Inhibitor DM69UZG RN Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800027759) DM69UZG RU http://adisinsight.springer.com/drugs/800027759 DMNF9P5 DI DMNF9P5 DMNF9P5 DN HR1P peptide DMNF9P5 MI TTJ4EIV DMNF9P5 MN MERS-CoV spike glycoprotein S2 subunit (S S2) DMNF9P5 MT DTT DMNF9P5 MA Inhibitor DMNF9P5 RN Structure-based discovery of Middle East respiratory syndrome coronavirus fusion inhibitor. Nat Commun. 2014;5:3067. DMNF9P5 RU https://pubmed.ncbi.nlm.nih.gov/24473083 DM6WC1Q DI DM6WC1Q DM6WC1Q DN HR2P peptide DM6WC1Q MI TTJ4EIV DM6WC1Q MN MERS-CoV spike glycoprotein S2 subunit (S S2) DM6WC1Q MT DTT DM6WC1Q MA Inhibitor DM6WC1Q RN Structure-based discovery of Middle East respiratory syndrome coronavirus fusion inhibitor. Nat Commun. 2014;5:3067. DM6WC1Q RU https://pubmed.ncbi.nlm.nih.gov/24473083 DMSR96X DI DMSR96X DMSR96X DN HR2P-M1 peptide DMSR96X MI TTJ4EIV DMSR96X MN MERS-CoV spike glycoprotein S2 subunit (S S2) DMSR96X MT DTT DMSR96X MA Inhibitor DMSR96X RN Structure-based discovery of Middle East respiratory syndrome coronavirus fusion inhibitor. Nat Commun. 2014;5:3067. DMSR96X RU https://pubmed.ncbi.nlm.nih.gov/24473083 DM7X4SV DI DM7X4SV DM7X4SV DN HR2P-M2 peptide DM7X4SV MI TTJ4EIV DM7X4SV MN MERS-CoV spike glycoprotein S2 subunit (S S2) DM7X4SV MT DTT DM7X4SV MA Inhibitor DM7X4SV RN Structure-based discovery of Middle East respiratory syndrome coronavirus fusion inhibitor. Nat Commun. 2014;5:3067. DM7X4SV RU https://pubmed.ncbi.nlm.nih.gov/24473083 DMR8VJA DI DMR8VJA DMR8VJA DN HSDB-41 DMR8VJA MI DE3YZC9 DMR8VJA MN Acetone carboxylase (ACX) DMR8VJA MT DME DMR8VJA MA Metabolism DMR8VJA RN The human gastric pathogen Helicobacter pylori has a potential acetone carboxylase that enhances its ability to colonize mice. BMC Microbiol. 2008 Jan 23;8:14. DMR8VJA RU https://pubmed.ncbi.nlm.nih.gov/18215283 DMR8VJA DI DMR8VJA DMR8VJA DN HSDB-41 DMR8VJA MI DEFUSL7 DMR8VJA MN Acetone carboxylase (ACX) DMR8VJA MT DME DMR8VJA MA Metabolism DMR8VJA RN The human gastric pathogen Helicobacter pylori has a potential acetone carboxylase that enhances its ability to colonize mice. BMC Microbiol. 2008 Jan 23;8:14. DMR8VJA RU https://pubmed.ncbi.nlm.nih.gov/18215283 DMUAPNF DI DMUAPNF DMUAPNF DN humanin DMUAPNF MI TTOJ1NF DMUAPNF MN FMLP-related receptor I (FPR2) DMUAPNF MT DTT DMUAPNF MA Agonist DMUAPNF RN N-Formylated humanin activates both formyl peptide receptor-like 1 and 2. Biochem Biophys Res Commun. 2004 Nov 5;324(1):255-61. DMUAPNF RU https://pubmed.ncbi.nlm.nih.gov/15465011 DMUAPNF DI DMUAPNF DMUAPNF DN humanin DMUAPNF MI TT16TM5 DMUAPNF MN N-formyl peptide receptor 3 (FPR3) DMUAPNF MT DTT DMUAPNF MA Agonist DMUAPNF RN N-Formylated humanin activates both formyl peptide receptor-like 1 and 2. Biochem Biophys Res Commun. 2004 Nov 5;324(1):255-61. DMUAPNF RU https://pubmed.ncbi.nlm.nih.gov/15465011 DM3NP4I DI DM3NP4I DM3NP4I DN Huntingtin gene antisense DM3NP4I MI TTIWZ0O DM3NP4I MN Huntingtin messenger RNA (HTT mRNA) DM3NP4I MT DTT DM3NP4I RN Design and development of antisense drugs. Expert Opin. Drug Discov. 2008 3(10):1189-1207. DM3NP4I RU http://www.informahealthcare.com/doi/abs/10.1517/17460441.3.10.1177 DM349AM DI DM349AM DM349AM DN HY-N0040 DM349AM MI DEUO7V8 DM349AM MN Beta-glucosidase (bglA) DM349AM MT DME DM349AM MA Metabolism DM349AM RN Constitutive beta-glucosidases hydrolyzing ginsenoside Rb1 and Rb2 from human intestinal bacteria. Biol Pharm Bull. 2000 Dec;23(12):1481-5. DM349AM RU https://pubmed.ncbi.nlm.nih.gov/11145182 DM349AM DI DM349AM DM349AM DN HY-N0040 DM349AM MI DE4LKZ9 DM349AM MN Beta-glucosidase (bglA) DM349AM MT DME DM349AM MA Metabolism DM349AM RN Constitutive beta-glucosidases hydrolyzing ginsenoside Rb1 and Rb2 from human intestinal bacteria. Biol Pharm Bull. 2000 Dec;23(12):1481-5. DM349AM RU https://pubmed.ncbi.nlm.nih.gov/11145182 DM349AM DI DM349AM DM349AM DN HY-N0040 DM349AM MI DEM6GYO DM349AM MN Beta-glucosidase (bglA) DM349AM MT DME DM349AM MA Metabolism DM349AM RN Constitutive beta-glucosidases hydrolyzing ginsenoside Rb1 and Rb2 from human intestinal bacteria. Biol Pharm Bull. 2000 Dec;23(12):1481-5. DM349AM RU https://pubmed.ncbi.nlm.nih.gov/11145182 DM349AM DI DM349AM DM349AM DN HY-N0040 DM349AM MI DERPJZ6 DM349AM MN Beta-glucosidase (bglA) DM349AM MT DME DM349AM MA Metabolism DM349AM RN Fermentation of protopanaxadiol type ginsenosides (PD) with probiotic Bifidobacterium lactis and Lactobacillus rhamnosus. Appl Microbiol Biotechnol. 2017 Jul;101(13):5427-5437. DM349AM RU https://pubmed.ncbi.nlm.nih.gov/28478490 DM349AM DI DM349AM DM349AM DN HY-N0040 DM349AM MI DEUQTKA DM349AM MN Beta-glucosidase (bglA) DM349AM MT DME DM349AM MA Metabolism DM349AM RN Fermentation of protopanaxadiol type ginsenosides (PD) with probiotic Bifidobacterium lactis and Lactobacillus rhamnosus. Appl Microbiol Biotechnol. 2017 Jul;101(13):5427-5437. DM349AM RU https://pubmed.ncbi.nlm.nih.gov/28478490 DML4IAX DI DML4IAX DML4IAX DN HY-N2258 DML4IAX MI DEBI82Z DML4IAX MN Alpha-L-rhamnosidase (lrA) DML4IAX MT DME DML4IAX MA Metabolism DML4IAX RN Metabolism of rutin and poncirin by human intestinal microbiota and cloning of their metabolizing alpha-L-rhamnosidase from Bifidobacterium dentium. J Microbiol Biotechnol. 2015 Jan;25(1):18-25. DML4IAX RU https://pubmed.ncbi.nlm.nih.gov/25179902 DMXB95R DI DMXB95R DMXB95R DN IC261 DMXB95R MI TTFQEMX DMXB95R MN Casein kinase I alpha (CSNK1A1) DMXB95R MT DTT DMXB95R MA Inhibitor DMXB95R RN Crystal structure of a conformation-selective casein kinase-1 inhibitor. J Biol Chem. 2000 Jun 30;275(26):20052-60. DMXB95R RU https://pubmed.ncbi.nlm.nih.gov/10749871 DMXB95R DI DMXB95R DMXB95R DN IC261 DMXB95R MI TTH30UI DMXB95R MN Casein kinase I delta (CSNK1D) DMXB95R MT DTT DMXB95R MA Inhibitor DMXB95R RN Crystal structure of a conformation-selective casein kinase-1 inhibitor. J Biol Chem. 2000 Jun 30;275(26):20052-60. DMXB95R RU https://pubmed.ncbi.nlm.nih.gov/10749871 DMXB95R DI DMXB95R DMXB95R DN IC261 DMXB95R MI TTA8PLI DMXB95R MN Casein kinase I epsilon (CSNK1E) DMXB95R MT DTT DMXB95R MA Inhibitor DMXB95R RN Crystal structure of a conformation-selective casein kinase-1 inhibitor. J Biol Chem. 2000 Jun 30;275(26):20052-60. DMXB95R RU https://pubmed.ncbi.nlm.nih.gov/10749871 DM1RZVI DI DM1RZVI DM1RZVI DN ICA-69673 DM1RZVI MI TTPXI3S DM1RZVI MN Voltage-gated potassium channel Kv7.2 (KCNQ2) DM1RZVI MT DTT DM1RZVI MA Modulator DM1RZVI RN Voltage-gated Potassium Channels as Therapeutic Drug Targets DM1RZVI RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2790170 DM1RZVI DI DM1RZVI DM1RZVI DN ICA-69673 DM1RZVI MI TTIVDM3 DM1RZVI MN Voltage-gated potassium channel Kv7.3 (KCNQ3) DM1RZVI MT DTT DM1RZVI MA Modulator DM1RZVI RN Voltage-gated Potassium Channels as Therapeutic Drug Targets DM1RZVI RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2790170 DMIYSD4 DI DMIYSD4 DMIYSD4 DN IDDB-41331 DMIYSD4 MI TTTM6W8 DMIYSD4 MN Melanin-concentrating hormone receptor (MCHR) DMIYSD4 MT DTT DMIYSD4 MA Antagonist DMIYSD4 RN Emerging drugs for obesity: linking novel biological mechanisms to pharmaceutical pipelines. Expert Opin Emerg Drugs. 2005 Aug;10(3):643-60. DMIYSD4 RU https://pubmed.ncbi.nlm.nih.gov/16083333 DMQ3BXV DI DMQ3BXV DMQ3BXV DN IDDBCP-150101 DMQ3BXV MI TTD0CIQ DMQ3BXV MN Melanocortin receptor 4 (MC4R) DMQ3BXV MT DTT DMQ3BXV MA Agonist DMQ3BXV RN Emerging drugs for obesity: linking novel biological mechanisms to pharmaceutical pipelines. Expert Opin Emerg Drugs. 2005 Aug;10(3):643-60. DMQ3BXV RU https://pubmed.ncbi.nlm.nih.gov/16083333 DMRIMZL DI DMRIMZL DMRIMZL DN IDX136 DMRIMZL MI TTIU7X1 DMRIMZL MN Herpes simplex virus DNA polymerase UL30 (HSV UL30) DMRIMZL MT DTT DMRIMZL MA Inhibitor DMRIMZL RN Therapy with amineptine, a dopamine reuptake inhibitor, in patients with major depression. Indian J Psychiatry. 1997 Apr;39(2):147-53. DMRIMZL RU https://pubmed.ncbi.nlm.nih.gov/21584062 DMXN2ZQ DI DMXN2ZQ DMXN2ZQ DN IMO-2134 DMXN2ZQ MI TTSHG0T DMXN2ZQ MN Toll-like receptor 9 (TLR9) DMXN2ZQ MT DTT DMXN2ZQ MA Agonist DMXN2ZQ RN Clinical pipeline report, company report or official report of Idera Pharmaceuticals (2011). DMXN2ZQ RU http://www.iderapharma.com/ DMV5KSA DI DMV5KSA DMV5KSA DN IMX-942 DMV5KSA MI TTOT2RY DMV5KSA MN Sequestosome-1 p62 (SQSTM1) DMV5KSA MT DTT DMV5KSA MA Regulator (upregulator) DMV5KSA RN Clinical pipeline report, company report or official report of SARomics Biostructures. DMV5KSA RU http://www.saromics.com/news/news/News2010.html DMXJO20 DI DMXJO20 DMXJO20 DN Indol-3-carbinol DMXJO20 MI TTUTN1I DMXJO20 MN Human Deoxyribonucleic acid (hDNA) DMXJO20 MT DTT DMXJO20 MA Binder DMXJO20 RN Novel antifungal agents, targets or therapeutic strategies for the treatment of invasive fungal diseases: a review of the literature (2005-2009). Rev Iberoam Micol. 2009 Mar 31;26(1):15-22. DMXJO20 RU https://pubmed.ncbi.nlm.nih.gov/19463273 DMXJO20 DI DMXJO20 DMXJO20 DN Indol-3-carbinol DMXJO20 MI TT27K59 DMXJO20 MN Platelet activating factor (PAF) DMXJO20 MT DTT DMXJO20 MA Inhibitor DMXJO20 RN Pinusolide from the leaves of Biota orientalis as potent platelet activating factor antagonist. Planta Med. 1999 Feb;65(1):39-42. DMXJO20 RU https://pubmed.ncbi.nlm.nih.gov/10083843 DMBQGZ9 DI DMBQGZ9 DMBQGZ9 DN INOC-005 DMBQGZ9 MI TT7HF4W DMBQGZ9 MN Cyclin-dependent kinase 2 (CDK2) DMBQGZ9 MT DTT DMBQGZ9 MA Inhibitor DMBQGZ9 RN What are next generation innovative therapeutic targets. J Pharmacol Exp Ther. 2009 Jul;330(1):304-15. DMBQGZ9 RU https://pubmed.ncbi.nlm.nih.gov/19357322 DMBQGZ9 DI DMBQGZ9 DMBQGZ9 DN INOC-005 DMBQGZ9 MI TT0PG8F DMBQGZ9 MN Cyclin-dependent kinase 4 (CDK4) DMBQGZ9 MT DTT DMBQGZ9 MA Inhibitor DMBQGZ9 RN Liposarcoma: molecular genetics and therapeutics. Sarcoma. 2011;2011:483154. DMBQGZ9 RU https://pubmed.ncbi.nlm.nih.gov/21253554 DMBQGZ9 DI DMBQGZ9 DMBQGZ9 DN INOC-005 DMBQGZ9 MI TTO0FDJ DMBQGZ9 MN Cyclin-dependent kinase 6 (CDK6) DMBQGZ9 MT DTT DMBQGZ9 MA Inhibitor DMBQGZ9 RN What are next generation innovative therapeutic targets. J Pharmacol Exp Ther. 2009 Jul;330(1):304-15. DMBQGZ9 RU https://pubmed.ncbi.nlm.nih.gov/19357322 DMRJ9P4 DI DMRJ9P4 DMRJ9P4 DN INT-767 DMRJ9P4 MI TTS4UGC DMRJ9P4 MN Farnesoid X-activated receptor (FXR) DMRJ9P4 MT DTT DMRJ9P4 MA Agonist DMRJ9P4 RN FXR/TGR5 Dual Agonist Prevents Progression of Nephropathy in Diabetes and Obesity. J Am Soc Nephrol. 2018 Jan;29(1):118-137. DMRJ9P4 RU https://pubmed.ncbi.nlm.nih.gov/29089371 DMRJ9P4 DI DMRJ9P4 DMRJ9P4 DN INT-767 DMRJ9P4 MI TTSDVTR DMRJ9P4 MN G-protein coupled bile acid receptor 1 (GPBAR1) DMRJ9P4 MT DTT DMRJ9P4 MA Agonist DMRJ9P4 RN FXR/TGR5 Dual Agonist Prevents Progression of Nephropathy in Diabetes and Obesity. J Am Soc Nephrol. 2018 Jan;29(1):118-137. DMRJ9P4 RU https://pubmed.ncbi.nlm.nih.gov/29089371 DMMUVAF DI DMMUVAF DMMUVAF DN IRX-4 DMMUVAF MI TT9G4N0 DMMUVAF MN Glutamate carboxypeptidase II (GCPII) DMMUVAF MT DTT DMMUVAF MA Immunomodulator (Immunostimulant) DMMUVAF RN Irx4 identifies a chamber-specific cell population that contributes to ventricular myocardium development. Dev Dyn. 2014 Mar;243(3):381-92. DMMUVAF RU https://pubmed.ncbi.nlm.nih.gov/24123507 DMJ0A2R DI DMJ0A2R DMJ0A2R DN IU1 DMJ0A2R MI TTVSYP9 DMJ0A2R MN Ubiquitin carboxyl-terminal hydrolase 14 (USP14) DMJ0A2R MT DTT DMJ0A2R MA Inhibitor DMJ0A2R RN Neurotoxic mechanisms by which the USP14 inhibitor IU1 depletes ubiquitinated proteins and Tau in rat cerebral cortical neurons: Relevance to Alzheimer's disease. Biochim Biophys Acta Mol Basis Dis. 2017 Jun;1863(6):1157-1170. DMJ0A2R RU https://pubmed.ncbi.nlm.nih.gov/28372990 DMTGI64 DI DMTGI64 DMTGI64 DN JD-5037 DMTGI64 MI TT6OEDT DMTGI64 MN Cannabinoid receptor 1 (CB1) DMTGI64 MT DTT DMTGI64 MA Agonist DMTGI64 RN 2011 Pipeline of Jenrin Discovery. DMTGI64 RU http://www.jenrindiscovery.com/pipeline.html DMSXOPE DI DMSXOPE DMSXOPE DN JNJ-26070109 DMSXOPE MI TTVFO0U DMSXOPE MN Gastrin/cholecystokinin type B receptor (CCKBR) DMSXOPE MT DTT DMSXOPE MA Antagonist DMSXOPE RN The cholecystokinin CCK2 receptor antagonist, JNJ-26070109, inhibits gastric acid secretion and prevents omeprazole-induced acid rebound in the rat. Br J Pharmacol. 2012 Jul;166(5):1684-93. DMSXOPE RU https://pubmed.ncbi.nlm.nih.gov/22300007 DMCNBHY DI DMCNBHY DMCNBHY DN JNJ-42905343 DMCNBHY MI TTJQFBG DMCNBHY MN HIF-prolyl hydroxylase (HPH) DMCNBHY MT DTT DMCNBHY MA Inhibitor DMCNBHY RN Prolyl hydroxylase inhibition corrects functional iron deficiency and inflammation-induced anaemia in rats. Br J Pharmacol. 2015 Aug;172(16):4078-88. DMCNBHY RU https://pubmed.ncbi.nlm.nih.gov/25988595 DMHBWOP DI DMHBWOP DMHBWOP DN JT07 DMHBWOP MI TT1UCIJ DMHBWOP MN C-X-C chemokine receptor type 3 (CXCR3) DMHBWOP MT DTT DMHBWOP MA Inhibitor DMHBWOP RN Clinical pipeline report, company report or official report of Jyant Technologies. DMHBWOP RU http://jyanttech.com/index.php?/pipeline DMHBWOP DI DMHBWOP DMHBWOP DN JT07 DMHBWOP MI TTRQJTC DMHBWOP MN C-X-C chemokine receptor type 7 (ACKR3) DMHBWOP MT DTT DMHBWOP MA Inhibitor DMHBWOP RN Clinical pipeline report, company report or official report of Jyant Technologies. DMHBWOP RU http://jyanttech.com/index.php?/pipeline DM8OAZ6 DI DM8OAZ6 DM8OAZ6 DN JT08 DM8OAZ6 MI TTIW59R DM8OAZ6 MN C-X-C chemokine receptor type 5 (CXCR5) DM8OAZ6 MT DTT DM8OAZ6 MA Inhibitor DM8OAZ6 RN Clinical pipeline report, company report or official report of Jyant Technologies. DM8OAZ6 RU http://jyanttech.com/index.php?/pipeline DM86YBK DI DM86YBK DM86YBK DN K11777 DM86YBK MI TTS586L DM86YBK MN HUMAN cathepsin L (CTSL) DM86YBK MT DTT DM86YBK MA Blocker DM86YBK RN Coronaviruses - drug discovery and therapeutic options. Nat Rev Drug Discov. 2016 May;15(5):327-47. DM86YBK RU https://pubmed.ncbi.nlm.nih.gov/26868298 DMIQXEP DI DMIQXEP DMIQXEP DN KD-3020 DMIQXEP MI TT2JWF6 DMIQXEP MN Peroxisome proliferator-activated receptor delta (PPARD) DMIQXEP MT DTT DMIQXEP MA Agonist DMIQXEP RN Emerging drugs for non-alcoholic fatty liver disease. Expert Opin Emerg Drugs. 2008 Mar;13(1):145-58. DMIQXEP RU https://pubmed.ncbi.nlm.nih.gov/18321154 DML93TN DI DML93TN DML93TN DN Kestose DML93TN MI DECWNTP DML93TN MN Beta-fructofuranosidase (BFRU) DML93TN MT DME DML93TN MA Metabolism DML93TN RN Characterization of fructooligosaccharide-degrading enzymes in human commensal Bifidobacterium longum and Anaerostipes caccae. Biochem Biophys Res Commun. 2019 Oct 15;518(2):294-298. DML93TN RU https://pubmed.ncbi.nlm.nih.gov/31420164 DML93TN DI DML93TN DML93TN DN Kestose DML93TN MI DEJ4FO2 DML93TN MN Sucrose phosphorylase (Spase) DML93TN MT DME DML93TN MA Metabolism DML93TN RN Characterization of fructooligosaccharide-degrading enzymes in human commensal Bifidobacterium longum and Anaerostipes caccae. Biochem Biophys Res Commun. 2019 Oct 15;518(2):294-298. DML93TN RU https://pubmed.ncbi.nlm.nih.gov/31420164 DML93TN DI DML93TN DML93TN DN Kestose DML93TN MI DEICTXP DML93TN MN Sucrose-6-phosphate hydrolase scrB (ScrB) DML93TN MT DME DML93TN MA Metabolism DML93TN RN Characterization of fructooligosaccharide-degrading enzymes in human commensal Bifidobacterium longum and Anaerostipes caccae. Biochem Biophys Res Commun. 2019 Oct 15;518(2):294-298. DML93TN RU https://pubmed.ncbi.nlm.nih.gov/31420164 DMHX1LA DI DMHX1LA DMHX1LA DN KL001 DMHX1LA MI TT5MLZR DMHX1LA MN Cryptochrome circadian clock 1 (CRY1) DMHX1LA MT DTT DMHX1LA MA Activator DMHX1LA RN Identification of small molecule activators of cryptochrome. Science. 2012 Aug 31;337(6098):1094-7. DMHX1LA RU https://pubmed.ncbi.nlm.nih.gov/22798407 DMHX1LA DI DMHX1LA DMHX1LA DN KL001 DMHX1LA MI TTAO58M DMHX1LA MN Cryptochrome-2 (CRY2) DMHX1LA MT DTT DMHX1LA MA Activator DMHX1LA RN Identification of small molecule activators of cryptochrome. Science. 2012 Aug 31;337(6098):1094-7. DMHX1LA RU https://pubmed.ncbi.nlm.nih.gov/22798407 DMFLIC0 DI DMFLIC0 DMFLIC0 DN KOS-1803 DMFLIC0 MI TTYFKSZ DMFLIC0 MN Tubulin beta (TUBB) DMFLIC0 MT DTT DMFLIC0 MA Inhibitor DMFLIC0 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2640). DMFLIC0 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2640 DMCGFY6 DI DMCGFY6 DMCGFY6 DN KOS-1815 DMCGFY6 MI TTCJUR4 DMCGFY6 MN Exportin-1 (XPO1) DMCGFY6 MT DTT DMCGFY6 MA Inhibitor DMCGFY6 RN Inhibition of CRM1-dependent nuclear export sensitizes malignant cells to cytotoxic and targeted agents. Semin Cancer Biol. 2014 August; 0: 62-73. DMCGFY6 RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4108511/ DMXY81K DI DMXY81K DMXY81K DN KOS-2484 DMXY81K MI TT78R5H DMXY81K MN Heat shock protein 90 alpha (HSP90A) DMXY81K MT DTT DMXY81K MA Inhibitor DMXY81K RN US patent application no. 2014,0079,636, Targeted therapeutics. DMXY81K RU http://www.google.com.na/patents/US20140079636 DMZCW3J DI DMZCW3J DMZCW3J DN KP3 DMZCW3J MI TTHDS05 DMZCW3J MN Klebsiella Fimbrial subunit type 3 (Klebsiella mrkA) DMZCW3J MT DTT DMZCW3J MA Inhibitor DMZCW3J RN Anti-MrkA Monoclonal Antibodies Reveal Distinct Structural and Antigenic Features of MrkA. PLoS One. 2017 Jan 20;12(1):e0170529. DMZCW3J RU https://pubmed.ncbi.nlm.nih.gov/28107434 DMMEH12 DI DMMEH12 DMMEH12 DN L-006235-1 DMMEH12 MI TTF2LRI DMMEH12 MN Cathepsin B (CTSB) DMMEH12 MT DTT DMMEH12 MA Inhibitor DMMEH12 RN Lysosomotropism of basic cathepsin K inhibitors contributes to increased cellular potencies against off-target cathepsins and reduced functional se... J Med Chem. 2005 Dec 1;48(24):7535-43. DMMEH12 RU https://pubmed.ncbi.nlm.nih.gov/16302795 DMMEH12 DI DMMEH12 DMMEH12 DN L-006235-1 DMMEH12 MI TTDZN01 DMMEH12 MN Cathepsin K (CTSK) DMMEH12 MT DTT DMMEH12 MA Inhibitor DMMEH12 RN Lysosomotropism of basic cathepsin K inhibitors contributes to increased cellular potencies against off-target cathepsins and reduced functional se... J Med Chem. 2005 Dec 1;48(24):7535-43. DMMEH12 RU https://pubmed.ncbi.nlm.nih.gov/16302795 DMMEH12 DI DMMEH12 DMMEH12 DN L-006235-1 DMMEH12 MI TT36ETB DMMEH12 MN Cathepsin L (CTSL) DMMEH12 MT DTT DMMEH12 MA Inhibitor DMMEH12 RN Lysosomotropism of basic cathepsin K inhibitors contributes to increased cellular potencies against off-target cathepsins and reduced functional se... J Med Chem. 2005 Dec 1;48(24):7535-43. DMMEH12 RU https://pubmed.ncbi.nlm.nih.gov/16302795 DMMEH12 DI DMMEH12 DMMEH12 DN L-006235-1 DMMEH12 MI TTUMQVO DMMEH12 MN Cathepsin S (CTSS) DMMEH12 MT DTT DMMEH12 MA Inhibitor DMMEH12 RN Lysosomotropism of basic cathepsin K inhibitors contributes to increased cellular potencies against off-target cathepsins and reduced functional se... J Med Chem. 2005 Dec 1;48(24):7535-43. DMMEH12 RU https://pubmed.ncbi.nlm.nih.gov/16302795 DMK3TXY DI DMK3TXY DMK3TXY DN L-742791 DMK3TXY MI TTMXGCW DMK3TXY MN Adrenergic receptor beta-3 (ADRB3) DMK3TXY MT DTT DMK3TXY MA Agonist DMK3TXY RN Emerging drugs for obesity: linking novel biological mechanisms to pharmaceutical pipelines. Expert Opin Emerg Drugs. 2005 Aug;10(3):643-60. DMK3TXY RU https://pubmed.ncbi.nlm.nih.gov/16083333 DMOERXK DI DMOERXK DMOERXK DN L-751250 DMOERXK MI TTMXGCW DMOERXK MN Adrenergic receptor beta-3 (ADRB3) DMOERXK MT DTT DMOERXK MA Agonist DMOERXK RN Emerging drugs for obesity: linking novel biological mechanisms to pharmaceutical pipelines. Expert Opin Emerg Drugs. 2005 Aug;10(3):643-60. DMOERXK RU https://pubmed.ncbi.nlm.nih.gov/16083333 DMOERXK DI DMOERXK DMOERXK DN L-751250 DMOERXK MI TTH6V3D DMOERXK MN Cyclin-dependent kinase 1 (CDK1) DMOERXK MT DTT DMOERXK MA Binder DMOERXK RN Down-regulation of survivin in nitric oxide-induced cell growth inhibition and apoptosis of the human lung carcinoma cells. J Biol Chem. 2004 May 7;279(19):20267-76. DMOERXK RU https://pubmed.ncbi.nlm.nih.gov/14988404 DMOERXK DI DMOERXK DMOERXK DN L-751250 DMOERXK MI TT7HF4W DMOERXK MN Cyclin-dependent kinase 2 (CDK2) DMOERXK MT DTT DMOERXK MA Inhibitor DMOERXK RN Pharmacological inhibitors of cyclin-dependent kinases. Trends Pharmacol Sci. 2002 Sep;23(9):417-25. DMOERXK RU https://pubmed.ncbi.nlm.nih.gov/12237154 DMOERXK DI DMOERXK DMOERXK DN L-751250 DMOERXK MI TTL4Q97 DMOERXK MN Cyclin-dependent kinase 5 (CDK5) DMOERXK MT DTT DMOERXK MA Inhibitor DMOERXK RN Pharmacological inhibitors of cyclin-dependent kinases. Trends Pharmacol Sci. 2002 Sep;23(9):417-25. DMOERXK RU https://pubmed.ncbi.nlm.nih.gov/12237154 DMFBMXD DI DMFBMXD DMFBMXD DN LAS-101057 DMFBMXD MI TTNE7KG DMFBMXD MN Adenosine A2b receptor (ADORA2B) DMFBMXD MT DTT DMFBMXD MA Antagonist DMFBMXD RN Discovery of LAS101057: A Potent, Selective, and Orally Efficacious A2B Adenosine Receptor Antagonist. ACS Med Chem Lett. 2010 Dec 20;2(3):213-8. DMFBMXD RU https://pubmed.ncbi.nlm.nih.gov/24900298 DM1982I DI DM1982I DM1982I DN LDN-57444 DM1982I MI TTX9IFP DM1982I MN Ubiquitin thioesterase L1 (UCHL1) DM1982I MT DTT DM1982I MA Inhibitor DM1982I RN Inhibition of UCH-L1 Deubiquitinating Activity with Two Forms of LDN-57444 Has Anti-Invasive Effects in Metastatic Carcinoma Cells. Int J Mol Sci. 2019 Jul 31;20(15):3733. DM1982I RU https://pubmed.ncbi.nlm.nih.gov/31370144 DMGJL16 DI DMGJL16 DMGJL16 DN LE-300 DMGJL16 MI TTS2PH3 DMGJL16 MN Dopamine D5 receptor (D5R) DMGJL16 MT DTT DMGJL16 MA Antagonist DMGJL16 RN The pipeline and future of drug development in schizophrenia. Mol Psychiatry. 2007 Oct;12(10):904-22. DMGJL16 RU https://pubmed.ncbi.nlm.nih.gov/17667958 DMJXZIS DI DMJXZIS DMJXZIS DN LH846 DMJXZIS MI TT7OGZP DMJXZIS MN Casein kinase 1 (CK1) DMJXZIS MT DTT DMJXZIS MA Inhibitor DMJXZIS RN A small molecule modulates circadian rhythms through phosphorylation of the period protein. Angew Chem Int Ed Engl. 2011 Nov 4;50(45):10608-11. DMJXZIS RU https://pubmed.ncbi.nlm.nih.gov/21954091 DMNOE1M DI DMNOE1M DMNOE1M DN LLY-507 DMNOE1M MI TT7YJFO DMNOE1M MN SET and MYND domain-containing protein 2 (SMYD2) DMNOE1M MT DTT DMNOE1M MA Inhibitor DMNOE1M RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2714). DMNOE1M RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2714 DMXYDMP DI DMXYDMP DMXYDMP DN LM10 DMXYDMP MI TTXNCBV DMXYDMP MN Tryptophan 2,3-dioxygenase (TDO) DMXYDMP MT DTT DMXYDMP MA Inhibitor DMXYDMP RN The autoimmune response elicited by mouse hepatitis virus (MHV-A59) infection is modulated by liver tryptophan-2,3-dioxygenase (TDO). Immunol Lett. 2020 Jan;217:25-30. DMXYDMP RU https://pubmed.ncbi.nlm.nih.gov/31726186 DMNIWF5 DI DMNIWF5 DMNIWF5 DN Lopinavir DMNIWF5 MI TTWOH4Q DMNIWF5 MN MERS-CoV 3C-like proteinase (3CLpro) DMNIWF5 MT DTT DMNIWF5 MA Inhibitor DMNIWF5 RN Coronaviruses - drug discovery and therapeutic options. Nat Rev Drug Discov. 2016 May;15(5):327-47. DMNIWF5 RU https://pubmed.ncbi.nlm.nih.gov/26868298 DMNIWF5 DI DMNIWF5 DMNIWF5 DN Lopinavir DMNIWF5 MI TTPZG3C DMNIWF5 MN SARS-CoV 3C-like protease (3CLpro) DMNIWF5 MT DTT DMNIWF5 MA Inhibitor DMNIWF5 RN Coronaviruses - drug discovery and therapeutic options. Nat Rev Drug Discov. 2016 May;15(5):327-47. DMNIWF5 RU https://pubmed.ncbi.nlm.nih.gov/26868298 DM0URLP DI DM0URLP DM0URLP DN Lopinavir + ritonavir + interferon alpha DM0URLP MI TT1D53B DM0URLP MN COVID-19 3C-like protease (3CLpro) DM0URLP MT DTT DM0URLP MA Inhibitor DM0URLP RN Coronavirus puts drug repurposing on the fast track. Nat Biotechnol. 2020 Apr;38(4):379-381. DM0URLP RU https://pubmed.ncbi.nlm.nih.gov/32205870 DMV1A25 DI DMV1A25 DMV1A25 DN LpxC-1 DMV1A25 MI TT0OFWN DMV1A25 MN Pseudomonas UDP-3-O-acyl-GlcNAc deacetylase (Pseudo lpxC) DMV1A25 MT DTT DMV1A25 MA Inhibitor DMV1A25 RN Different drugs for bad bugs: antivirulence strategies in the age of antibiotic resistance. Nat Rev Drug Discov. 2017 Jul;16(7):457-471. DMV1A25 RU https://pubmed.ncbi.nlm.nih.gov/28337021 DM7XPDB DI DM7XPDB DM7XPDB DN LY-2463665 DM7XPDB MI TTDIGC1 DM7XPDB MN Dipeptidyl peptidase 4 (DPP-4) DM7XPDB MT DTT DM7XPDB MA Inhibitor DM7XPDB RN Emerging drug candidates of dipeptidyl peptidase IV (DPP IV) inhibitor class for the treatment of Type 2 Diabetes. Curr Drug Targets. 2009 Jan;10(1):71-87. DM7XPDB RU https://pubmed.ncbi.nlm.nih.gov/19149538 DM2N637 DI DM2N637 DM2N637 DN LY-25582 DM2N637 MI TT27RFC DM2N637 MN Opioid receptor delta (OPRD1) DM2N637 MT DTT DM2N637 MA Inhibitor DM2N637 RN Investigation of the N-substituent conformation governing potency and mu receptor subtype-selectivity in (+)-(3R, 4R)-dimethyl-4-(3-hydroxyphenyl)p... J Med Chem. 1998 May 21;41(11):1980-90. DM2N637 RU https://pubmed.ncbi.nlm.nih.gov/9599247 DM2N637 DI DM2N637 DM2N637 DN LY-25582 DM2N637 MI TTQW87Y DM2N637 MN Opioid receptor kappa (OPRK1) DM2N637 MT DTT DM2N637 MA Inhibitor DM2N637 RN Investigation of the N-substituent conformation governing potency and mu receptor subtype-selectivity in (+)-(3R, 4R)-dimethyl-4-(3-hydroxyphenyl)p... J Med Chem. 1998 May 21;41(11):1980-90. DM2N637 RU https://pubmed.ncbi.nlm.nih.gov/9599247 DM2N637 DI DM2N637 DM2N637 DN LY-25582 DM2N637 MI TTKWM86 DM2N637 MN Opioid receptor mu (MOP) DM2N637 MT DTT DM2N637 MA Antagonist DM2N637 RN Structure activity relationship studies of carboxamido-biaryl ethers as opioid receptor antagonists (OpRAs). Part 2. Bioorg Med Chem Lett. 2007 Dec 15;17(24):6841-6. DM2N637 RU https://pubmed.ncbi.nlm.nih.gov/17980586 DMUFIO9 DI DMUFIO9 DMUFIO9 DN M102 DMUFIO9 MI TTA6ZN2 DMUFIO9 MN Nuclear factor erythroid 2-related factor 2 (Nrf2) DMUFIO9 MT DTT DMUFIO9 MA Activator DMUFIO9 RN Clinical pipeline report, company report or official report of Aclipse Therapeutics. DMUFIO9 RU https://aclipsetherapeutics.com/therapeutics/m102/ DM7HUVB DI DM7HUVB DM7HUVB DN m337 DM7HUVB MI TTZ3COY DM7HUVB MN COVID-19 spike glycoprotein (S) DM7HUVB MT DTT DM7HUVB MA Inhibitor DM7HUVB RN Coronaviruses - drug discovery and therapeutic options. Nat Rev Drug Discov. 2016 May;15(5):327-47. DM7HUVB RU https://pubmed.ncbi.nlm.nih.gov/26868298 DM32XJS DI DM32XJS DM32XJS DN M64 DM32XJS MI TT7L1ZX DM32XJS MN Pseudomonas Multiple virulence factor regulator MvfR (Pseudo MvfR) DM32XJS MT DTT DM32XJS MA Inhibitor DM32XJS RN Different drugs for bad bugs: antivirulence strategies in the age of antibiotic resistance. Nat Rev Drug Discov. 2017 Jul;16(7):457-471. DM32XJS RU https://pubmed.ncbi.nlm.nih.gov/28337021 DM5IMAU DI DM5IMAU DM5IMAU DN MAb173 DM5IMAU MI TTBID49 DM5IMAU MN C-X-C chemokine receptor type 4 (CXCR4) DM5IMAU MT DTT DM5IMAU MA Antagonist DM5IMAU RN Caspase-dependent apoptosis of cells expressing the chemokine receptor CXCR4 is induced by cell membrane-associated human immunodeficiency virus type 1 envelope glycoprotein (gp120). Virology. 2000 Mar 15;268(2):329-44. DM5IMAU RU https://pubmed.ncbi.nlm.nih.gov/10704341 DMNO20J DI DMNO20J DMNO20J DN mAb926 DMNO20J MI TTTCRU2 DMNO20J MN Bacterial Fimbrin D-mannose adhesin (Bact FimH) DMNO20J MT DTT DMNO20J MA Inhibitor DMNO20J RN FimH as a scaffold for regulated molecular recognition. J Biol Eng. 2021 Jan 12;15(1):3. DMNO20J RU https://pubmed.ncbi.nlm.nih.gov/33436006 DMZHT39 DI DMZHT39 DMZHT39 DN Macrolactin A DMZHT39 MI DEHD2Q8 DMZHT39 MN Glycosyltransferase (Gtf) DMZHT39 MT DME DMZHT39 MA Metabolism DMZHT39 RN A bacterial glycosyltransferase gene toolbox: generation and applications. Phytochemistry. 2009 Oct-Nov;70(15-16):1812-21. DMZHT39 RU https://pubmed.ncbi.nlm.nih.gov/19559449 DM1XYGF DI DM1XYGF DM1XYGF DN MAX-10129 DM1XYGF MI TT23XQV DM1XYGF MN PD-1-PD-L1 interaction (PD-1/PD-L1 PPI) DM1XYGF MT DTT DM1XYGF MA Inhibitor DM1XYGF RN Development of Inhibitors of the Programmed Cell Death-1/Programmed Cell Death-Ligand 1 Signaling Pathway.J Med Chem. 2019 Feb 28;62(4):1715-1730. DM1XYGF RU https://pubmed.ncbi.nlm.nih.gov/30247903 DMBT2RJ DI DMBT2RJ DMBT2RJ DN MC-2001 DMBT2RJ MI TTGJCWZ DMBT2RJ MN Fms-like tyrosine kinase 3 (FLT-3) DMBT2RJ MT DTT DMBT2RJ MA Inhibitor DMBT2RJ RN Vascular endothelial growth factor and its receptors in multiple myeloma. Leukemia. 2003 Oct;17(10):1961-6. DMBT2RJ RU https://pubmed.ncbi.nlm.nih.gov/14513045 DMBT2RJ DI DMBT2RJ DMBT2RJ DN MC-2001 DMBT2RJ MI TT3PJMV DMBT2RJ MN Tyrosine-protein kinase ABL1 (ABL) DMBT2RJ MT DTT DMBT2RJ MA Inhibitor DMBT2RJ RN Vascular endothelial growth factor and its receptors in multiple myeloma. Leukemia. 2003 Oct;17(10):1961-6. DMBT2RJ RU https://pubmed.ncbi.nlm.nih.gov/14513045 DMLK2D0 DI DMLK2D0 DMLK2D0 DN MC-3001 DMLK2D0 MI TTJ584C DMLK2D0 MN Peroxisome proliferator-activated receptor alpha (PPARA) DMLK2D0 MT DTT DMLK2D0 MA Agonist DMLK2D0 RN Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800021175) DMLK2D0 RU http://adisinsight.springer.com/drugs/800021175 DM7UGY9 DI DM7UGY9 DM7UGY9 DN MC-3002 DM7UGY9 MI TTJ584C DM7UGY9 MN Peroxisome proliferator-activated receptor alpha (PPARA) DM7UGY9 MT DTT DM7UGY9 MA Modulator DM7UGY9 RN Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41. DM7UGY9 RU https://www.ncbi.nlm.nih.gov/pubmed/15950434 DM7UGY9 DI DM7UGY9 DM7UGY9 DN MC-3002 DM7UGY9 MI TTZMAO3 DM7UGY9 MN Peroxisome proliferator-activated receptor gamma (PPAR-gamma) DM7UGY9 MT DTT DM7UGY9 MA Modulator DM7UGY9 RN Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41. DM7UGY9 RU https://www.ncbi.nlm.nih.gov/pubmed/15950434 DMHJLPS DI DMHJLPS DMHJLPS DN M-carboxycinnamic acid bishydroxamide DMHJLPS MI TT6R7JZ DMHJLPS MN Histone deacetylase 1 (HDAC1) DMHJLPS MT DTT DMHJLPS MA Inhibitor DMHJLPS RN Histone deacetylase inhibitors in cancer therapy: latest developments, trends and medicinal chemistry perspective. Anticancer Agents Med Chem. 2007 Sep;7(5):576-92. DMHJLPS RU https://pubmed.ncbi.nlm.nih.gov/17896917 DMYEFKH DI DMYEFKH DMYEFKH DN MCP-1 DMYEFKH MI TTFZYTO DMYEFKH MN C-C chemokine receptor type 2 (CCR2) DMYEFKH MT DTT DMYEFKH MA Antagonist DMYEFKH RN Emerging drugs for the treatment of chronic obstructive pulmonary disease. Expert Opin Emerg Drugs. 2006 May;11(2):275-91. DMYEFKH RU https://pubmed.ncbi.nlm.nih.gov/16634702 DMYEFKH DI DMYEFKH DMYEFKH DN MCP-1 DMYEFKH MI TTNAY0P DMYEFKH MN Monocyte chemotactic and activating factor (CCL2) DMYEFKH MT DTT DMYEFKH MA Inhibitor DMYEFKH RN Emerging drugs for the treatment of chronic obstructive pulmonary disease. Expert Opin Emerg Drugs. 2006 May;11(2):275-91. DMYEFKH RU https://pubmed.ncbi.nlm.nih.gov/16634702 DM7Q1PF DI DM7Q1PF DM7Q1PF DN MEDI-543 DM7Q1PF MI TTRJB2G DM7Q1PF MN Ephrin type-A receptor 2 (EPHA2) DM7Q1PF MT DTT DM7Q1PF RN Clinical and biological impact of EphA2 overexpression and angiogenesis in endometrial cancer. Cancer Biol Ther. 2010 Dec 15;10(12):1306-14. DM7Q1PF RU https://pubmed.ncbi.nlm.nih.gov/20948320 DMYK8MV DI DMYK8MV DMYK8MV DN Melanotetan II DMYK8MV MI TTNI91K DMYK8MV MN Melanocortin receptor 3 (MC3R) DMYK8MV MT DTT DMYK8MV MA Agonist DMYK8MV RN Emerging drugs for obesity: linking novel biological mechanisms to pharmaceutical pipelines. Expert Opin Emerg Drugs. 2005 Aug;10(3):643-60. DMYK8MV RU https://pubmed.ncbi.nlm.nih.gov/16083333 DMYK8MV DI DMYK8MV DMYK8MV DN Melanotetan II DMYK8MV MI TTD0CIQ DMYK8MV MN Melanocortin receptor 4 (MC4R) DMYK8MV MT DTT DMYK8MV MA Agonist DMYK8MV RN Emerging drugs for obesity: linking novel biological mechanisms to pharmaceutical pipelines. Expert Opin Emerg Drugs. 2005 Aug;10(3):643-60. DMYK8MV RU https://pubmed.ncbi.nlm.nih.gov/16083333 DMX4IS3 DI DMX4IS3 DMX4IS3 DN Mephenoxalone DMX4IS3 MI DTZGT0P DMX4IS3 MN Multidrug and toxin extrusion protein 1 (SLC47A1) DMX4IS3 MT DTP DMX4IS3 MA Substrate DMX4IS3 RN Preclinical and clinical evidence for the collaborative transport and renal secretion of an oxazolidinone antibiotic by organic anion transporter 3 (OAT3/SLC22A8) and multidrug and toxin extrusion protein 1 (MATE1/SLC47A1). J Pharmacol Exp Ther. 2010 Sep 1;334(3):936-44. DMX4IS3 RU http://www.ncbi.nlm.nih.gov/pubmed/20519552 DMTQXS7 DI DMTQXS7 DMTQXS7 DN Mercaptopurine DMTQXS7 MI TTYJOLE DMTQXS7 MN MERS-CoV papain-like proteinase (PL-PRO) DMTQXS7 MT DTT DMTQXS7 MA Inhibitor DMTQXS7 RN Thiopurine analogs and mycophenolic acid synergistically inhibit the papain-like protease of Middle East respiratory syndrome coronavirus. Antiviral Res. 2015 Mar;115:9-16. DMTQXS7 RU https://pubmed.ncbi.nlm.nih.gov/25542975 DMTQXS7 DI DMTQXS7 DMTQXS7 DN Mercaptopurine DMTQXS7 MI TTRGHB2 DMTQXS7 MN SARS-CoV papain-like proteinase (PL-PRO) DMTQXS7 MT DTT DMTQXS7 MA Inhibitor DMTQXS7 RN Thiopurine analogs and mycophenolic acid synergistically inhibit the papain-like protease of Middle East respiratory syndrome coronavirus. Antiviral Res. 2015 Mar;115:9-16. DMTQXS7 RU https://pubmed.ncbi.nlm.nih.gov/25542975 DMVGIB4 DI DMVGIB4 DMVGIB4 DN MERS-27 DMVGIB4 MI TTZ3COY DMVGIB4 MN COVID-19 spike glycoprotein (S) DMVGIB4 MT DTT DMVGIB4 MA Inhibitor DMVGIB4 RN Coronaviruses - drug discovery and therapeutic options. Nat Rev Drug Discov. 2016 May;15(5):327-47. DMVGIB4 RU https://pubmed.ncbi.nlm.nih.gov/26868298 DMS6KT8 DI DMS6KT8 DMS6KT8 DN MERS-4 DMS6KT8 MI TTZ3COY DMS6KT8 MN COVID-19 spike glycoprotein (S) DMS6KT8 MT DTT DMS6KT8 MA Inhibitor DMS6KT8 RN Coronaviruses - drug discovery and therapeutic options. Nat Rev Drug Discov. 2016 May;15(5):327-47. DMS6KT8 RU https://pubmed.ncbi.nlm.nih.gov/26868298 DMG5YRP DI DMG5YRP DMG5YRP DN MERS-five-helix bundle DMG5YRP MI TT85VHW DMG5YRP MN MERS-CoV spike glycoprotein (S) DMG5YRP MT DTT DMG5YRP MA Inhibitor DMG5YRP RN Identification of a Novel Inhibitor against Middle East Respiratory Syndrome Coronavirus. Viruses. 2017 Sep 14;9(9). pii: E255. DMG5YRP RU https://pubmed.ncbi.nlm.nih.gov/28906430 DMQW5MH DI DMQW5MH DMQW5MH DN Metampicillin DMQW5MH MI DT9G7XN DMQW5MH MN Peptide transporter 1 (SLC15A1) DMQW5MH MT DTP DMQW5MH MA Substrate DMQW5MH RN Transport characteristics of a novel peptide transporter 1 substrate, antihypotensive drug midodrine, and its amino acid derivatives. J Pharmacol Exp Ther. 2006 Jul;318(1):455-60. DMQW5MH RU http://www.ncbi.nlm.nih.gov/pubmed/16597710 DMQW5MH DI DMQW5MH DMQW5MH DN Metampicillin DMQW5MH MI DT8QKNP DMQW5MH MN Peptide transporter 2 (SLC15A2) DMQW5MH MT DTP DMQW5MH MA Substrate DMQW5MH RN Transport characteristics of a novel peptide transporter 1 substrate, antihypotensive drug midodrine, and its amino acid derivatives. J Pharmacol Exp Ther. 2006 Jul;318(1):455-60. DMQW5MH RU http://www.ncbi.nlm.nih.gov/pubmed/16597710 DMDPV82 DI DMDPV82 DMDPV82 DN Metildigoxin DMDPV82 MI DTUGYRD DMDPV82 MN P-glycoprotein 1 (ABCB1) DMDPV82 MT DTP DMDPV82 MA Substrate DMDPV82 RN KEGG: new perspectives on genomes, pathways, diseases and drugs. Nucleic Acids Res. 2017 Jan 4;45(D1):D353-D361. (dg:DG01665) DMDPV82 RU https://www.kegg.jp/dbget-bin/www_bget?dg:DG01665 DMDU8KC DI DMDU8KC DMDU8KC DN Metkephamid DMDU8KC MI DTUGYRD DMDU8KC MN P-glycoprotein 1 (ABCB1) DMDU8KC MT DTP DMDU8KC MA Substrate DMDU8KC RN Fingerprint-based in silico models for the prediction of P-glycoprotein substrates and inhibitors. Bioorg Med Chem. 2012 Sep 15;20(18):5388-95. DMDU8KC RU https://doi.org/10.1016/j.bmc.2012.03.045 DMKA2YS DI DMKA2YS DMKA2YS DN MG-132 DMKA2YS MI DTUGYRD DMKA2YS MN P-glycoprotein 1 (ABCB1) DMKA2YS MT DTP DMKA2YS MA Substrate DMKA2YS RN Increased ABCB1 expression in TP-110-resistant RPMI-8226 cells. Biosci Biotechnol Biochem. 2010;74(9):1913-9. DMKA2YS RU https://doi.org/10.1271/bbb.100325 DMI3E0Y DI DMI3E0Y DMI3E0Y DN MK6-83 DMI3E0Y MI TT9XBVO DMI3E0Y MN Mucolipin-1 (TRPML1) DMI3E0Y MT DTT DMI3E0Y MA Agonist DMI3E0Y RN ML-SA1, a selective TRPML agonist, inhibits DENV2 and ZIKV by promoting lysosomal acidification and protease activity. Antiviral Res. 2020 Oct;182:104922. DMI3E0Y RU https://pubmed.ncbi.nlm.nih.gov/32858116 DMV2F84 DI DMV2F84 DMV2F84 DN ML209 DMV2F84 MI TTGV6LY DMV2F84 MN Nuclear receptor ROR-gamma (RORG) DMV2F84 MT DTT DMV2F84 MA Agonist DMV2F84 RN ROR nuclear receptors: structures, related diseases, and drug discovery. Acta Pharmacol Sin. 2015 Jan;36(1):71-87. DMV2F84 RU https://pubmed.ncbi.nlm.nih.gov/25500868 DMY91A3 DI DMY91A3 DMY91A3 DN ML323 DMY91A3 MI TTG9MT5 DMY91A3 MN Deubiquitinating enzyme 1 (USP1) DMY91A3 MT DTT DMY91A3 MA Inhibitor DMY91A3 RN Synthesis and structure-activity relationship studies of N-benzyl-2-phenylpyrimidin-4-amine derivatives as potent USP1/UAF1 deubiquitinase inhibitors with anticancer activity against nonsmall cell lung cancer. J Med Chem. 2014 Oct 9;57(19):8099-110. DMY91A3 RU https://pubmed.ncbi.nlm.nih.gov/25229643 DM6RFLE DI DM6RFLE DM6RFLE DN ML364 DM6RFLE MI TTUEQ1W DM6RFLE MN Ubiquitin carboxyl-terminal hydrolase 2 (USP2) DM6RFLE MT DTT DM6RFLE MA Inhibitor DM6RFLE RN The deubiquitylase USP2 maintains ErbB2 abundance via counteracting endocytic degradation and represents a therapeutic target in ErbB2-positive breast cancer. Cell Death Differ. 2020 Sep;27(9):2710-2725. DM6RFLE RU https://pubmed.ncbi.nlm.nih.gov/32327714 DMEK78T DI DMEK78T DMEK78T DN MNLP-18 DMEK78T MI TTZ7HX8 DMEK78T MN Glycoside hydrolase (GlyH) DMEK78T MT DTT DMEK78T MA Inhibitor DMEK78T RN viral infection therapy, MNLpharma MNLpharma partnering opportunity, Worldwide, R & D Focus Drug News, May 29, 2006 DMEK78T RU http://business.highbeam.com/436989/article-1G1-146237368/viral-infection-therapy-mnlpharma-mnlpharma-partnering DMG2UJS DI DMG2UJS DMG2UJS DN Monomethyl-auristatin-E DMG2UJS MI DTQ3ZHF DMG2UJS MN Multidrug resistance-associated protein 3 (ABCC3) DMG2UJS MT DTP DMG2UJS MA Substrate DMG2UJS RN Functional genomics identifies ABCC3 as a mediator of taxane resistance in HER2-amplified breast cancer. Cancer Res. 2008 Jul 1;68(13):5380-9. DMG2UJS RU https://doi.org/10.1158/0008-5472.CAN-08-0234 DM5AMFV DI DM5AMFV DM5AMFV DN MS012 DM5AMFV MI TTS6RZT DM5AMFV MN Histone-lysine N-methyltransferase EHMT2 (EHMT2) DM5AMFV MT DTT DM5AMFV MA Inhibitor DM5AMFV RN Epigenetics and beyond: targeting writers of protein lysine methylation to treat disease. Nat Rev Drug Discov. 2021 Apr;20(4):265-286. DM5AMFV RU https://pubmed.ncbi.nlm.nih.gov/33469207 DMDEJBQ DI DMDEJBQ DMDEJBQ DN MS2177 DMDEJBQ MI TTGC95K DMDEJBQ MN SET domain containing 8 (KMT5A) DMDEJBQ MT DTT DMDEJBQ MA Inhibitor DMDEJBQ RN Epigenetics and beyond: targeting writers of protein lysine methylation to treat disease. Nat Rev Drug Discov. 2021 Apr;20(4):265-286. DMDEJBQ RU https://pubmed.ncbi.nlm.nih.gov/33469207 DMCZW4Q DI DMCZW4Q DMCZW4Q DN Mteron-F1 DMCZW4Q MI TTNDSF4 DMCZW4Q MN Proto-oncogene c-Met (MET) DMCZW4Q MT DTT DMCZW4Q MA Stimulator DMCZW4Q RN Emerging drugs for chemotherapy-induced mucositis. Expert Opin Emerg Drugs. 2008 Sep;13(3):511-22. DMCZW4Q RU https://pubmed.ncbi.nlm.nih.gov/18764726 DMC3NSK DI DMC3NSK DMC3NSK DN MUT-056399 DMC3NSK MI TTFKXOM DMC3NSK MN Bacterial NADH-dependent enoyl-ACP reductase (Bact fabI) DMC3NSK MT DTT DMC3NSK MA Modulator DMC3NSK RN The MUT056399 inhibitor of FabI is a new antistaphylococcal compound. Antimicrob Agents Chemother. 2011 Oct;55(10):4692-7. DMC3NSK RU https://pubmed.ncbi.nlm.nih.gov/21825292 DMC3NSK DI DMC3NSK DMC3NSK DN MUT-056399 DMC3NSK MI TTZBRVL DMC3NSK MN Staphylococcus Enoyl ACP reductase (Stap-coc fabI) DMC3NSK MT DTT DMC3NSK MA Modulator DMC3NSK RN The MUT056399 inhibitor of FabI is a new antistaphylococcal compound. Antimicrob Agents Chemother. 2011 Oct;55(10):4692-7. DMC3NSK RU https://pubmed.ncbi.nlm.nih.gov/21825292 DMDE7OR DI DMDE7OR DMDE7OR DN NA-808 DMDE7OR MI TTZVMA7 DMDE7OR MN Serine palmitoyltransferase (SPTC) DMDE7OR MT DTT DMDE7OR MA Modulator DMDE7OR RN Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41. DMDE7OR RU https://www.ncbi.nlm.nih.gov/pubmed/15950434 DMEHO9G DI DMEHO9G DMEHO9G DN NC043 DMEHO9G MI TTQ9EDI DMEHO9G MN Ubiquitin carboxyl-terminal hydrolase 30 (USP30) DMEHO9G MT DTT DMEHO9G MA Inhibitor DMEHO9G RN A small natural molecule promotes mitochondrial fusion through inhibition of the deubiquitinase USP30. Cell Res. 2014 Apr;24(4):482-96. DMEHO9G RU https://pubmed.ncbi.nlm.nih.gov/24513856 DMXG0O1 DI DMXG0O1 DMXG0O1 DN NCGC607 DMXG0O1 MI TT1B5PU DMXG0O1 MN Glucosylceramidase (GBA) DMXG0O1 MT DTT DMXG0O1 MA Inhibitor DMXG0O1 RN A New Glucocerebrosidase Chaperone Reduces alpha-Synuclein and Glycolipid Levels in iPSC-Derived Dopaminergic Neurons from Patients with Gaucher Disease and Parkinsonism. J Neurosci. 2016 Jul 13;36(28):7441-52. DMXG0O1 RU https://pubmed.ncbi.nlm.nih.gov/27413154 DM5ATJ0 DI DM5ATJ0 DM5ATJ0 DN N-desethyl sunitinib DM5ATJ0 MI DTI7UX6 DM5ATJ0 MN Breast cancer resistance protein (ABCG2) DM5ATJ0 MT DTP DM5ATJ0 MA Substrate DM5ATJ0 RN P-glycoprotein (ABCB1) and breast cancer resistance protein (ABCG2) restrict brain accumulation of the active sunitinib metabolite N-desethyl sunitinib. J Pharmacol Exp Ther. 2012 Apr;341(1):164-73. DM5ATJ0 RU https://doi.org/10.1124/jpet.111.186908 DM5ATJ0 DI DM5ATJ0 DM5ATJ0 DN N-desethyl sunitinib DM5ATJ0 MI DTUGYRD DM5ATJ0 MN P-glycoprotein 1 (ABCB1) DM5ATJ0 MT DTP DM5ATJ0 MA Substrate DM5ATJ0 RN P-glycoprotein (ABCB1) and breast cancer resistance protein (ABCG2) restrict brain accumulation of the active sunitinib metabolite N-desethyl sunitinib. J Pharmacol Exp Ther. 2012 Apr;341(1):164-73. DM5ATJ0 RU https://doi.org/10.1124/jpet.111.186908 DMX7Q3H DI DMX7Q3H DMX7Q3H DN Nemorubicin DMX7Q3H MI TT0IHXV DMX7Q3H MN DNA topoisomerase II (TOP2) DMX7Q3H MT DTT DMX7Q3H MA Modulator DMX7Q3H RN The interaction of nemorubicin metabolite PNU-159682 with DNA fragments d(CGTACG)(2), d(CGATCG)(2) and d(CGCGCG)(2) shows a strong but reversible binding to G:C base pairs. Bioorg Med Chem. 2012 Dec 15;20(24):6979-88. DMX7Q3H RU https://pubmed.ncbi.nlm.nih.gov/23154079 DMW1LKP DI DMW1LKP DMW1LKP DN Nicotinamide mononucleotide DMW1LKP MI DT0OA2B DMW1LKP MN Cation-chloride cotransporter 9 (SLC12A8) DMW1LKP MT DTP DMW1LKP MA Substrate DMW1LKP RN Slc12a8 is a nicotinamide mononucleotide transporter. Nature Metabolismvolume 1, pages4757 (2019). DMW1LKP RU https://www.nature.com/articles/s42255-018-0009-4 DMK8UD0 DI DMK8UD0 DMK8UD0 DN NKP-46 DMK8UD0 MI TTBWDI0 DMK8UD0 MN Ribonucleoside-diphosphate reductase M2 (RRM2) DMK8UD0 MT DTT DMK8UD0 RN Phase I and pharmacokinetic study of the oral tris-(8-quinolinolato)gallium(III) complex (FFC11, KP46) in patients with solid tumors - a study of the CESAR Central European Society for Anticancer Drug Research - EWIV. J Clin Oncol (Meeting Abstracts) June 2005 vol. 23 no. 16_suppl 3205. DMK8UD0 RU http://meeting.ascopubs.org/cgi/content/short/23/16_suppl/3205 DMVUKEW DI DMVUKEW DMVUKEW DN N-methylpyridinium DMVUKEW MI DTZGT0P DMVUKEW MN Multidrug and toxin extrusion protein 1 (SLC47A1) DMVUKEW MT DTP DMVUKEW MA Substrate DMVUKEW RN Substrate specificity of MATE1 and MATE2-K, human multidrug and toxin extrusions/H(+)-organic cation antiporters. Biochem Pharmacol. 2007 Jul 15;74(2):359-71. DMVUKEW RU http://www.ncbi.nlm.nih.gov/pubmed/17509534 DMVUKEW DI DMVUKEW DMVUKEW DN N-methylpyridinium DMVUKEW MI DT3TX4H DMVUKEW MN Multidrug and toxin extrusion protein 2 (SLC47A2) DMVUKEW MT DTP DMVUKEW MA Substrate DMVUKEW RN Substrate specificity of MATE1 and MATE2-K, human multidrug and toxin extrusions/H(+)-organic cation antiporters. Biochem Pharmacol. 2007 Jul 15;74(2):359-71. DMVUKEW RU http://www.ncbi.nlm.nih.gov/pubmed/17509534 DMVUKEW DI DMVUKEW DMVUKEW DN N-methylpyridinium DMVUKEW MI DTT79CX DMVUKEW MN Organic cation transporter 1 (SLC22A1) DMVUKEW MT DTP DMVUKEW MA Substrate DMVUKEW RN Interaction of oral antidiabetic drugs with hepatic uptake transporters: focus on organic anion transporting polypeptides and organic cation transporter 1. Diabetes. 2008 Jun;57(6):1463-9. DMVUKEW RU http://www.ncbi.nlm.nih.gov/pubmed/18314419 DMVUKEW DI DMVUKEW DMVUKEW DN N-methylpyridinium DMVUKEW MI DT9IDPW DMVUKEW MN Organic cation transporter 2 (SLC22A2) DMVUKEW MT DTP DMVUKEW MA Substrate DMVUKEW RN Functional characterization of the human organic cation transporter 2 variant p.270Ala>Ser. Drug Metab Dispos. 2009 Jun;37(6):1312-8. DMVUKEW RU http://www.ncbi.nlm.nih.gov/pubmed/19251820 DMVUKEW DI DMVUKEW DMVUKEW DN N-methylpyridinium DMVUKEW MI DT6201N DMVUKEW MN Organic cation transporter 3 (SLC22A3) DMVUKEW MT DTP DMVUKEW MA Substrate DMVUKEW RN Structure, function, and regional distribution of the organic cation transporter OCT3 in the kidney. Am J Physiol Renal Physiol. 2000 Sep;279(3):F449-58. DMVUKEW RU http://www.ncbi.nlm.nih.gov/pubmed/10966924 DMLNYGX DI DMLNYGX DMLNYGX DN NN-818 DMLNYGX MI TTE4KHA DMLNYGX MN Amyloid beta A4 protein (APP) DMLNYGX MT DTT DMLNYGX MA Modulator DMLNYGX RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2402). DMLNYGX RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2402 DM7R3B6 DI DM7R3B6 DM7R3B6 DN Nobiletin DM7R3B6 MI TTGV6LY DM7R3B6 MN Nuclear receptor ROR-gamma (RORG) DM7R3B6 MT DTT DM7R3B6 MA Agonist DM7R3B6 RN The Small Molecule Nobiletin Targets the Molecular Oscillator to Enhance Circadian Rhythms and Protect against Metabolic Syndrome. Cell Metab. 2016 Apr 12;23(4):610-21. DM7R3B6 RU https://pubmed.ncbi.nlm.nih.gov/27076076 DMTQ2UD DI DMTQ2UD DMTQ2UD DN N-Octyl-4-epi-beta-valienamine DMTQ2UD MI TTNGJPH DMTQ2UD MN Beta-galactosidase (GLB1) DMTQ2UD MT DTT DMTQ2UD MA Inhibitor DMTQ2UD RN Chemical modification of the beta-glucocerebrosidase inhibitor N-octyl-beta-valienamine: synthesis and biological evaluation of 4-epimeric and 4-O-(beta-D-galactopyranosyl) derivatives. Bioorg Med Chem. 2002 Jun;10(6):1967-72. DMTQ2UD RU https://pubmed.ncbi.nlm.nih.gov/11937356 DM39C47 DI DM39C47 DM39C47 DN N-Octyl-beta-valienamine DM39C47 MI TT1B5PU DM39C47 MN Glucosylceramidase (GBA) DM39C47 MT DTT DM39C47 MA Inhibitor DM39C47 RN Chemical modification of the beta-glucocerebrosidase inhibitor N-octyl-beta-valienamine: synthesis and biological evaluation of 4-epimeric and 4-O-(beta-D-galactopyranosyl) derivatives. Bioorg Med Chem. 2002 Jun;10(6):1967-72. DM39C47 RU https://pubmed.ncbi.nlm.nih.gov/11937356 DMKF2H0 DI DMKF2H0 DMKF2H0 DN Nonactin DMKF2H0 MI DTUGYRD DMKF2H0 MN P-glycoprotein 1 (ABCB1) DMKF2H0 MT DTP DMKF2H0 MA Substrate DMKF2H0 RN Potential role of drug transporters in the pathogenesis of medically intractable epilepsy. Epilepsia. 2005 Feb;46(2):224-35. DMKF2H0 RU https://doi.org/10.1111/j.0013-9580.2005.31904.x DM83DSA DI DM83DSA DM83DSA DN NOX-F37 DM83DSA MI TT4TFGN DM83DSA MN Vasopressin V1a receptor (V1AR) DM83DSA MT DTT DM83DSA MA Antagonist DM83DSA RN Emerging drugs for acute and chronic heart failure: current and future developments. Expert Opin Emerg Drugs. 2007 Mar;12(1):75-95. DM83DSA RU https://pubmed.ncbi.nlm.nih.gov/17355215 DMOGRWB DI DMOGRWB DMOGRWB DN NPS-1034 DMOGRWB MI TTNDSF4 DMOGRWB MN Proto-oncogene c-Met (MET) DMOGRWB MT DTT DMOGRWB MA Inhibitor DMOGRWB RN NPS-1034, a novel MET inhibitor, inhibits the activated MET receptor and its constitutively active mutants. Invest New Drugs. 2014 Jun;32(3):389-99. DMOGRWB RU https://pubmed.ncbi.nlm.nih.gov/24173966 DMMRY0Z DI DMMRY0Z DMMRY0Z DN NPS-2390 DMMRY0Z MI TTBUYHA DMMRY0Z MN Extracellular calcium-sensing receptor (CASR) DMMRY0Z MT DTT DMMRY0Z MA Modulator DMMRY0Z RN The Extracellular Calcium-Sensing Receptor (CASR) Regulates Gonadotropins-Induced Meiotic Maturation of Porcine Oocytes.Biol Reprod.2015 Dec;93(6):131. DMMRY0Z RU https://www.ncbi.nlm.nih.gov/pubmed/26490840 DMMRY0Z DI DMMRY0Z DMMRY0Z DN NPS-2390 DMMRY0Z MI TTVBPDM DMMRY0Z MN Metabotropic glutamate receptor 1 (mGluR1) DMMRY0Z MT DTT DMMRY0Z MA Inhibitor DMMRY0Z RN Positive and negative modulation of group I metabotropic glutamate receptors. J Med Chem. 2008 Feb 14;51(3):634-47. DMMRY0Z RU https://pubmed.ncbi.nlm.nih.gov/18173231 DMXUCSN DI DMXUCSN DMXUCSN DN NPY5RA-972 DMXUCSN MI TTY6EWA DMXUCSN MN Neuropeptide Y receptor type 5 (NPY5R) DMXUCSN MT DTT DMXUCSN MA Antagonist DMXUCSN RN Emerging drugs for obesity: linking novel biological mechanisms to pharmaceutical pipelines. Expert Opin Emerg Drugs. 2005 Aug;10(3):643-60. DMXUCSN RU https://pubmed.ncbi.nlm.nih.gov/16083333 DMO5MUY DI DMO5MUY DMO5MUY DN NSC-207895 DMO5MUY MI TT9OUDQ DMO5MUY MN p53-binding protein Mdm4 (MDM4) DMO5MUY MT DTT DMO5MUY MA Inhibitor DMO5MUY RN Emerging therapies targeting the ubiquitin proteasome system in cancer. J Clin Invest. 2014 Jan;124(1):6-12. DMO5MUY RU https://pubmed.ncbi.nlm.nih.gov/24382383 DMQRZ4T DI DMQRZ4T DMQRZ4T DN NSC632839 DMQRZ4T MI TTX9IFP DMQRZ4T MN Ubiquitin thioesterase L1 (UCHL1) DMQRZ4T MT DTT DMQRZ4T MA Inhibitor DMQRZ4T RN Ubiquitin C-Terminal Hydrolase L1 regulates autophagy by inhibiting autophagosome formation through its deubiquitinating enzyme activity. Biochem Biophys Res Commun. 2018 Mar 4;497(2):726-733. DMQRZ4T RU https://pubmed.ncbi.nlm.nih.gov/29462615 DM65UZ2 DI DM65UZ2 DM65UZ2 DN NTU281 DM65UZ2 MI TT2F4OL DM65UZ2 MN Tissue transglutaminase (TG2) DM65UZ2 MT DTT DM65UZ2 MA Inhibitor DM65UZ2 RN Drugs and Targets in Fibrosis. Front Pharmacol. 2017 Nov 23;8:855. DM65UZ2 RU https://pubmed.ncbi.nlm.nih.gov/29218009 DMO5EXL DI DMO5EXL DMO5EXL DN NVP-2 DMO5EXL MI TT1LVF2 DMO5EXL MN Cyclin-dependent kinase 9 (CDK9) DMO5EXL MT DTT DMO5EXL MA Inhibitor DMO5EXL RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1981). DMO5EXL RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1981 DMEXLU5 DI DMEXLU5 DMEXLU5 DN ON-01135 DMEXLU5 MI TTH6V3D DMEXLU5 MN Cyclin-dependent kinase 1 (CDK1) DMEXLU5 MT DTT DMEXLU5 MA Inhibitor DMEXLU5 RN Phase 1 study of intravenous rigosertib (ON 01910.Na), a novel benzyl styryl sulfone structure producing G2/M arrest and apoptosis, in adult patients with advanced cancer. Am J Cancer Res. 2013; 3(3): 323-338. DMEXLU5 RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3696538/ DMMBIHO DI DMMBIHO DMMBIHO DN ONO-1301 DMMBIHO MI TTKNWZ4 DMMBIHO MN Thromboxane-A synthase (TBXAS1) DMMBIHO MT DTT DMMBIHO MA Agonist DMMBIHO RN A synthetic prostacyclin agonist with thromboxane synthase inhibitory activity, ONO-1301, protects myocardium from ischemia/reperfusion injury. Eur J Pharmacol. 2012 Jan 15;674(2-3):352-8. DMMBIHO RU https://pubmed.ncbi.nlm.nih.gov/22094066 DMHQUM2 DI DMHQUM2 DMHQUM2 DN Org-23366 DMHQUM2 MI TTJQOD7 DMHQUM2 MN 5-HT 2A receptor (HTR2A) DMHQUM2 MT DTT DMHQUM2 MA Antagonist DMHQUM2 RN The pipeline and future of drug development in schizophrenia. Mol Psychiatry. 2007 Oct;12(10):904-22. DMHQUM2 RU https://pubmed.ncbi.nlm.nih.gov/17667958 DMHQUM2 DI DMHQUM2 DMHQUM2 DN Org-23366 DMHQUM2 MI TTEX248 DMHQUM2 MN Dopamine D2 receptor (D2R) DMHQUM2 MT DTT DMHQUM2 MA Antagonist DMHQUM2 RN The pipeline and future of drug development in schizophrenia. Mol Psychiatry. 2007 Oct;12(10):904-22. DMHQUM2 RU https://pubmed.ncbi.nlm.nih.gov/17667958 DMHQUM2 DI DMHQUM2 DMHQUM2 DN Org-23366 DMHQUM2 MI TTH18TF DMHQUM2 MN Muscarinic acetylcholine receptor M5 (CHRM5) DMHQUM2 MT DTT DMHQUM2 MA Antagonist DMHQUM2 RN The pipeline and future of drug development in schizophrenia. Mol Psychiatry. 2007 Oct;12(10):904-22. DMHQUM2 RU https://pubmed.ncbi.nlm.nih.gov/17667958 DMCMS7V DI DMCMS7V DMCMS7V DN Org-24461 DMCMS7V MI TTHJTF7 DMCMS7V MN Glycine transporter GlyT-1 (SLC6A9) DMCMS7V MT DTT DMCMS7V MA Blocker DMCMS7V RN The pipeline and future of drug development in schizophrenia. Mol Psychiatry. 2007 Oct;12(10):904-22. DMCMS7V RU https://pubmed.ncbi.nlm.nih.gov/17667958 DMERWUC DI DMERWUC DMERWUC DN Organon DMERWUC MI DE4LYSA DMERWUC MN Cytochrome P450 3A4 (CYP3A4) DMERWUC MT DME DMERWUC MA Metabolism DMERWUC RN Identification of the human P450 enzymes involved in the in vitro metabolism of the synthetic steroidal hormones Org 4060 and Org 30659. Xenobiotica. 2002 Feb;32(2):109-18. DMERWUC RU https://www.ncbi.nlm.nih.gov/pubmed/?term=11871398 DMERWUC DI DMERWUC DMERWUC DN Organon DMERWUC MI TTHJTF7 DMERWUC MN Glycine transporter GlyT-1 (SLC6A9) DMERWUC MT DTT DMERWUC MA Blocker DMERWUC RN The pipeline and future of drug development in schizophrenia. Mol Psychiatry. 2007 Oct;12(10):904-22. DMERWUC RU https://pubmed.ncbi.nlm.nih.gov/17667958 DM46QXZ DI DM46QXZ DM46QXZ DN Organon-2 DM46QXZ MI TTHJTF7 DM46QXZ MN Glycine transporter GlyT-1 (SLC6A9) DM46QXZ MT DTT DM46QXZ MA Blocker DM46QXZ RN The pipeline and future of drug development in schizophrenia. Mol Psychiatry. 2007 Oct;12(10):904-22. DM46QXZ RU https://pubmed.ncbi.nlm.nih.gov/17667958 DM07EU4 DI DM07EU4 DM07EU4 DN Organon-3 DM07EU4 MI TTHJTF7 DM07EU4 MN Glycine transporter GlyT-1 (SLC6A9) DM07EU4 MT DTT DM07EU4 MA Blocker DM07EU4 RN The pipeline and future of drug development in schizophrenia. Mol Psychiatry. 2007 Oct;12(10):904-22. DM07EU4 RU https://pubmed.ncbi.nlm.nih.gov/17667958 DMPUSM5 DI DMPUSM5 DMPUSM5 DN Otamixaban DMPUSM5 MI TTK9LUQ DMPUSM5 MN HUAMN serine protease factor Xa (SERPINA5) DMPUSM5 MT DTT DMPUSM5 MA Inhibitor DMPUSM5 RN A rational roadmap for SARS-CoV-2/COVID-19 pharmacotherapeutic research and development: IUPHAR Review 29. Br J Pharmacol. 2020 May 1;10.1111/bph.15094. DMPUSM5 RU https://pubmed.ncbi.nlm.nih.gov/32358833 DMYKG8R DI DMYKG8R DMYKG8R DN Oxypertine DMYKG8R MI DTAV4SY DMYKG8R MN Sodium-dependent serotonin transporter (SLC6A4) DMYKG8R MT DTP DMYKG8R MA Substrate DMYKG8R RN Serotonin transporter gene and treatment of alcoholism. DMYKG8R RU https://patents.google.com/patent/CA2760675A1 DMD8JIC DI DMD8JIC DMD8JIC DN P22077 DMD8JIC MI TTXU3EQ DMD8JIC MN Herpesvirus ubiquitin-specific protease (HAUSP) DMD8JIC MT DTT DMD8JIC MA Inhibitor DMD8JIC RN P22077 inhibits LPS-induced inflammatory response by promoting K48-linked ubiquitination and degradation of TRAF6. Aging (Albany NY). 2020 Jun 9;12(11):10969-10982. DMD8JIC RU https://pubmed.ncbi.nlm.nih.gov/32516131 DMGIR3F DI DMGIR3F DMGIR3F DN P5091 DMGIR3F MI TTXU3EQ DMGIR3F MN Herpesvirus ubiquitin-specific protease (HAUSP) DMGIR3F MT DTT DMGIR3F MA Inhibitor DMGIR3F RN USP7 inhibitor P5091 inhibits Wnt signaling and colorectal tumor growth. Biochem Pharmacol. 2017 May 1;131:29-39. DMGIR3F RU https://pubmed.ncbi.nlm.nih.gov/28216017 DM3YUGA DI DM3YUGA DM3YUGA DN Pancratistatin DM3YUGA MI DTI7UX6 DM3YUGA MN Breast cancer resistance protein (ABCG2) DM3YUGA MT DTP DM3YUGA MA Substrate DM3YUGA RN Identification of compounds that correlate with ABCG2 transporter function in the National Cancer Institute Anticancer Drug Screen. Mol Pharmacol. 2009 Nov;76(5):946-56. DM3YUGA RU https://doi.org/10.1124/mol.109.056192 DMNIM96 DI DMNIM96 DMNIM96 DN P-BCMA-ALL01 DMNIM96 MI TTZ3P4W DMNIM96 MN B-cell maturation protein (TNFRSF17) DMNIM96 MT DTT DMNIM96 RN Clinical pipeline report, company report or official report of Poseida Therapeutics. DMNIM96 RU https://poseida.com/science/pipeline/ DMW3TGI DI DMW3TGI DMW3TGI DN PCI-45292 DMW3TGI MI TTGM6VW DMW3TGI MN Tyrosine-protein kinase BTK (ATK) DMW3TGI MT DTT DMW3TGI MA Inhibitor DMW3TGI RN Ibrutinib is an irreversible molecular inhibitor of ITK driving a Th1-selective pressure in T lymphocytes. Blood. 2013 October 10; 122(15): 2539-2549. DMW3TGI RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3795457/ DMTG730 DI DMTG730 DMTG730 DN PD-157533 DMTG730 MI TT4C8EA DMTG730 MN Dopamine D3 receptor (D3R) DMTG730 MT DTT DMTG730 MA Antagonist DMTG730 RN The pipeline and future of drug development in schizophrenia. Mol Psychiatry. 2007 Oct;12(10):904-22. DMTG730 RU https://pubmed.ncbi.nlm.nih.gov/17667958 DMDSR1X DI DMDSR1X DMDSR1X DN PD-157695 DMDSR1X MI TT38ECI DMDSR1X MN Bacterial Hydroxymethyl-dihydropterin pyrophosphokinase (Bact folK) DMDSR1X MT DTT DMDSR1X MA Inhibitor DMDSR1X RN Bisubstrate analogue inhibitors of 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase: synthesis and biochemical and crystallographic studies. J Med Chem. 2001 Apr 26;44(9):1364-71. DMDSR1X RU https://pubmed.ncbi.nlm.nih.gov/11311059 DMDSR1X DI DMDSR1X DMDSR1X DN PD-157695 DMDSR1X MI TT30C9G DMDSR1X MN C-X-C chemokine receptor type 2 (CXCR2) DMDSR1X MT DTT DMDSR1X MA Antagonist DMDSR1X RN Interleukin-8 receptor antagonists in pulmonary diseases. Curr Opin Pharmacol. 2001 Jun;1(3):242-7. DMDSR1X RU https://pubmed.ncbi.nlm.nih.gov/11712746 DMDSR1X DI DMDSR1X DMDSR1X DN PD-157695 DMDSR1X MI TTEX248 DMDSR1X MN Dopamine D2 receptor (D2R) DMDSR1X MT DTT DMDSR1X MA Antagonist DMDSR1X RN The pipeline and future of drug development in schizophrenia. Mol Psychiatry. 2007 Oct;12(10):904-22. DMDSR1X RU https://pubmed.ncbi.nlm.nih.gov/17667958 DMDSR1X DI DMDSR1X DMDSR1X DN PD-157695 DMDSR1X MI TT4C8EA DMDSR1X MN Dopamine D3 receptor (D3R) DMDSR1X MT DTT DMDSR1X MA Antagonist DMDSR1X RN The pipeline and future of drug development in schizophrenia. Mol Psychiatry. 2007 Oct;12(10):904-22. DMDSR1X RU https://pubmed.ncbi.nlm.nih.gov/17667958 DM682UV DI DM682UV DM682UV DN PD-158771 DM682UV MI TTSQIFT DM682UV MN 5-HT 1A receptor (HTR1A) DM682UV MT DTT DM682UV MA Antagonist DM682UV RN The pipeline and future of drug development in schizophrenia. Mol Psychiatry. 2007 Oct;12(10):904-22. DM682UV RU https://pubmed.ncbi.nlm.nih.gov/17667958 DM682UV DI DM682UV DM682UV DN PD-158771 DM682UV MI TTEX248 DM682UV MN Dopamine D2 receptor (D2R) DM682UV MT DTT DM682UV MA Antagonist DM682UV RN The pipeline and future of drug development in schizophrenia. Mol Psychiatry. 2007 Oct;12(10):904-22. DM682UV RU https://pubmed.ncbi.nlm.nih.gov/17667958 DM682UV DI DM682UV DM682UV DN PD-158771 DM682UV MI TT4C8EA DM682UV MN Dopamine D3 receptor (D3R) DM682UV MT DTT DM682UV MA Antagonist DM682UV RN The pipeline and future of drug development in schizophrenia. Mol Psychiatry. 2007 Oct;12(10):904-22. DM682UV RU https://pubmed.ncbi.nlm.nih.gov/17667958 DMB9Z4C DI DMB9Z4C DMB9Z4C DN PD-160170 DMB9Z4C MI TTRK9JT DMB9Z4C MN Neuropeptide Y receptor type 1 (NPY1R) DMB9Z4C MT DTT DMB9Z4C MA Antagonist DMB9Z4C RN Emerging drugs for obesity: linking novel biological mechanisms to pharmaceutical pipelines. Expert Opin Emerg Drugs. 2005 Aug;10(3):643-60. DMB9Z4C RU https://pubmed.ncbi.nlm.nih.gov/16083333 DMD0GB4 DI DMD0GB4 DMD0GB4 DN PD-165167 DMD0GB4 MI TTE0A2F DMD0GB4 MN Dopamine D4 receptor (D4R) DMD0GB4 MT DTT DMD0GB4 MA Antagonist DMD0GB4 RN The pipeline and future of drug development in schizophrenia. Mol Psychiatry. 2007 Oct;12(10):904-22. DMD0GB4 RU https://pubmed.ncbi.nlm.nih.gov/17667958 DMEOVDQ DI DMEOVDQ DMEOVDQ DN PD-170292 DMEOVDQ MI TTCG0AL DMEOVDQ MN Cholecystokinin receptor type A (CCKAR) DMEOVDQ MT DTT DMEOVDQ MA Agonist DMEOVDQ RN Emerging drugs for obesity: linking novel biological mechanisms to pharmaceutical pipelines. Expert Opin Emerg Drugs. 2005 Aug;10(3):643-60. DMEOVDQ RU https://pubmed.ncbi.nlm.nih.gov/16083333 DMEOVDQ DI DMEOVDQ DMEOVDQ DN PD-170292 DMEOVDQ MI TTVFO0U DMEOVDQ MN Gastrin/cholecystokinin type B receptor (CCKBR) DMEOVDQ MT DTT DMEOVDQ MA Agonist DMEOVDQ RN Emerging drugs for obesity: linking novel biological mechanisms to pharmaceutical pipelines. Expert Opin Emerg Drugs. 2005 Aug;10(3):643-60. DMEOVDQ RU https://pubmed.ncbi.nlm.nih.gov/16083333 DMA5T3J DI DMA5T3J DMA5T3J DN Pepticlere DMA5T3J MI TTE4KHA DMA5T3J MN Amyloid beta A4 protein (APP) DMA5T3J MT DTT DMA5T3J MA Inhibitor DMA5T3J RN Preclinical trail of Pepticlere (DP-74) for treating Alzheimer's disease. ProteoTech Inc. DMA5T3J RU http://www.biocentury.com/products/pepticlere DMMWQTI DI DMMWQTI DMMWQTI DN Peptide P21S10 DMMWQTI MI TT85VHW DMMWQTI MN MERS-CoV spike glycoprotein (S) DMMWQTI MT DTT DMMWQTI MA Inhibitor DMMWQTI RN Discovery of Hydrocarbon-Stapled Short -Helical Peptides as Promising Middle East Respiratory Syndrome Coronavirus (MERS-CoV) Fusion Inhibitors. J Med Chem. 2018 Mar 8;61(5):2018-2026. DMMWQTI RU https://pubmed.ncbi.nlm.nih.gov/29442512 DM3U2S5 DI DM3U2S5 DM3U2S5 DN PF-04859989 DM3U2S5 MI TTT3IXG DM3U2S5 MN Kynurenine oxoglutarate transaminase II (AADAT) DM3U2S5 MT DTT DM3U2S5 MA Inhibitor DM3U2S5 RN Investigating KYNA production and kynurenergic manipulation on acute mouse brain slice preparations. Brain Res Bull. 2019 Mar;146:185-191. DM3U2S5 RU https://pubmed.ncbi.nlm.nih.gov/30639278 DM8P9ST DI DM8P9ST DM8P9ST DN PF-4800567 DM8P9ST MI TTH30UI DM8P9ST MN Casein kinase I delta (CSNK1D) DM8P9ST MT DTT DM8P9ST MA Inhibitor DM8P9ST RN Selective inhibition of casein kinase 1 epsilon minimally alters circadian clock period. J Pharmacol Exp Ther. 2009 Aug;330(2):430-9. DM8P9ST RU https://pubmed.ncbi.nlm.nih.gov/19458106 DM8P9ST DI DM8P9ST DM8P9ST DN PF-4800567 DM8P9ST MI TTA8PLI DM8P9ST MN Casein kinase I epsilon (CSNK1E) DM8P9ST MT DTT DM8P9ST MA Inhibitor DM8P9ST RN Selective inhibition of casein kinase 1 epsilon minimally alters circadian clock period. J Pharmacol Exp Ther. 2009 Aug;330(2):430-9. DM8P9ST RU https://pubmed.ncbi.nlm.nih.gov/19458106 DMTJBP9 DI DMTJBP9 DMTJBP9 DN PF-670462 DMTJBP9 MI TTH30UI DMTJBP9 MN Casein kinase I delta (CSNK1D) DMTJBP9 MT DTT DMTJBP9 MA Inhibitor DMTJBP9 RN Casein kinase 1 is a therapeutic target in chronic lymphocytic leukemia. Blood. 2018 Mar 15;131(11):1206-1218. DMTJBP9 RU https://pubmed.ncbi.nlm.nih.gov/29317454 DMTJBP9 DI DMTJBP9 DMTJBP9 DN PF-670462 DMTJBP9 MI TTA8PLI DMTJBP9 MN Casein kinase I epsilon (CSNK1E) DMTJBP9 MT DTT DMTJBP9 MA Inhibitor DMTJBP9 RN Casein kinase 1 is a therapeutic target in chronic lymphocytic leukemia. Blood. 2018 Mar 15;131(11):1206-1218. DMTJBP9 RU https://pubmed.ncbi.nlm.nih.gov/29317454 DMNZG8T DI DMNZG8T DMNZG8T DN PF-821385 DMNZG8T MI TTBYP1X DMNZG8T MN Human immunodeficiency virus Envelope glycoprotein gp120 (HIV gp120) DMNZG8T MT DTT DMNZG8T MA Inhibitor DMNZG8T RN Increased Functional Stability and Homogeneity of Viral Envelope Spikes through Directed Evolution. PLoS Pathog. 2013 February; 9(2): e1003184. DMNZG8T RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3585149/ DM1A2UI DI DM1A2UI DM1A2UI DN PGX-200097 DM1A2UI MI TTKWFB8 DM1A2UI MN Catechol-O-methyl-transferase (COMT) DM1A2UI MT DTT DM1A2UI MA Inhibitor DM1A2UI RN Schizophrenia, "just the facts" 5. Treatment and prevention. Past, present, and future. Schizophr Res. 2010 Sep;122(1-3):1-23. DM1A2UI RU https://pubmed.ncbi.nlm.nih.gov/20655178 DM1A2UI DI DM1A2UI DM1A2UI DN PGX-200097 DM1A2UI MI TTEX248 DM1A2UI MN Dopamine D2 receptor (D2R) DM1A2UI MT DTT DM1A2UI MA Inhibitor DM1A2UI RN Schizophrenia, "just the facts" 5. Treatment and prevention. Past, present, and future. Schizophr Res. 2010 Sep;122(1-3):1-23. DM1A2UI RU https://pubmed.ncbi.nlm.nih.gov/20655178 DMM149N DI DMM149N DMM149N DN PHA-568487 DMM149N MI TTLA931 DMM149N MN Neuronal acetylcholine receptor alpha-7 (CHRNA7) DMM149N MT DTT DMM149N MA Agonist DMM149N RN Multiple species metabolism of PHA-568487, a selective alpha 7 nicotinic acetylcholine receptor agonist. Drug Metab Lett. 2010 Aug;4(3):162-72. DMM149N RU https://pubmed.ncbi.nlm.nih.gov/20642449 DMIGH6W DI DMIGH6W DMIGH6W DN PHENSERINE TARTRATE DMIGH6W MI TT1RS9F DMIGH6W MN Acetylcholinesterase (AChE) DMIGH6W MT DTT DMIGH6W MA Inhibitor DMIGH6W RN An overview of phenserine tartrate, a novel acetylcholinesterase inhibitor for the treatment of Alzheimer's disease. Curr Alzheimer Res. 2005 Jul;2(3):281-90. DMIGH6W RU https://pubmed.ncbi.nlm.nih.gov/15974893 DM16W8F DI DM16W8F DM16W8F DN Phenylisoserine derivatives SK80 DM16W8F MI TTPZG3C DM16W8F MN SARS-CoV 3C-like protease (3CLpro) DM16W8F MT DTT DM16W8F MA Inhibitor DM16W8F RN Synthesis and Evaluation of Phenylisoserine Derivatives for the SARS-CoV 3CL Protease Inhibitor. Bioorg Med Chem Lett. 2017 Jun 15;27(12):2746-2751. DM16W8F RU https://pubmed.ncbi.nlm.nih.gov/28454669 DMIZCOE DI DMIZCOE DMIZCOE DN Piperlongumine DMIZCOE MI TTWO3SH DMIZCOE MN Glutathione S-transferase omega-1 (GSTO-1) DMIZCOE MT DTT DMIZCOE MA Inhibitor DMIZCOE RN Activity-based protein profiling reveals GSTO1 as the covalent target of piperlongumine and a promising target for combination therapy for cancer. Chem Commun (Camb). 2019 Apr 9;55(30):4407-4410. DMIZCOE RU https://pubmed.ncbi.nlm.nih.gov/30916079 DM82Y75 DI DM82Y75 DM82Y75 DN PIRINIXIC ACID DM82Y75 MI TTJ584C DM82Y75 MN Peroxisome proliferator-activated receptor alpha (PPARA) DM82Y75 MT DTT DM82Y75 MA Inhibitor DM82Y75 RN O-arylmandelic acids as highly selective human PPAR alpha/gamma agonists. Bioorg Med Chem Lett. 2003 Oct 6;13(19):3185-90. DM82Y75 RU https://pubmed.ncbi.nlm.nih.gov/12951090 DMXO6YH DI DMXO6YH DMXO6YH DN PJ34 DMXO6YH MI TTVDSZ0 DMXO6YH MN Poly [ADP-ribose] polymerase 1 (PARP1) DMXO6YH MT DTT DMXO6YH MA Inhibitor DMXO6YH RN Diabetic endothelial dysfunction: the role of poly(ADP-ribose) polymerase activation. Nat Med. 2001 Jan;7(1):108-13. DMXO6YH RU https://pubmed.ncbi.nlm.nih.gov/11135624 DM94ZOI DI DM94ZOI DM94ZOI DN PMID21925774-compound-5e DM94ZOI MI TTQKWR5 DM94ZOI MN SARS-CoV helicase (Hel) DM94ZOI MT DTT DM94ZOI MA Inhibitor DM94ZOI RN 2,6-Bis-arylmethyloxy-5-hydroxychromones With Antiviral Activity Against Both Hepatitis C Virus (HCV) and SARS-associated Coronavirus (SCV) Eur J Med Chem. 2011 Nov;46(11):5698-704. DM94ZOI RU https://pubmed.ncbi.nlm.nih.gov/21925774 DMOHPX4 DI DMOHPX4 DMOHPX4 DN PMID25197057-Compound6e DMOHPX4 MI TTEN986 DMOHPX4 MN Staphylococcus Sortase A (Stap-coc srtA) DMOHPX4 MT DTT DMOHPX4 MA Inhibitor DMOHPX4 RN Different drugs for bad bugs: antivirulence strategies in the age of antibiotic resistance. Nat Rev Drug Discov. 2017 Jul;16(7):457-471. DMOHPX4 RU https://pubmed.ncbi.nlm.nih.gov/28337021 DMFNS7U DI DMFNS7U DMFNS7U DN PMID26048809-compound2 DMFNS7U MI TTOA6YT DMFNS7U MN MERS-CoV RNA-directed RNA polymerase (RdRp) DMFNS7U MT DTT DMFNS7U MA Inhibitor DMFNS7U RN Coronaviruses - drug discovery and therapeutic options. Nat Rev Drug Discov. 2016 May;15(5):327-47. DMFNS7U RU https://pubmed.ncbi.nlm.nih.gov/26868298 DMZMYU5 DI DMZMYU5 DMZMYU5 DN PMID26868298-compound-5705213 DMZMYU5 MI TTS586L DMZMYU5 MN HUMAN cathepsin L (CTSL) DMZMYU5 MT DTT DMZMYU5 MA Blocker DMZMYU5 RN Coronaviruses - drug discovery and therapeutic options. Nat Rev Drug Discov. 2016 May;15(5):327-47. DMZMYU5 RU https://pubmed.ncbi.nlm.nih.gov/26868298 DMQFUCD DI DMQFUCD DMQFUCD DN PMID26868298-compound-N3 DMQFUCD MI TTNHMO8 DMQFUCD MN COVID-19 papain-like proteinase (PL-PRO) DMQFUCD MT DTT DMQFUCD MA Inhibitor DMQFUCD RN Structure of Mpro from COVID-19 virus and discovery of its inhibitors. Nature. 2020 Apr 9. DMQFUCD RU https://pubmed.ncbi.nlm.nih.gov/32272481 DMQFUCD DI DMQFUCD DMQFUCD DN PMID26868298-compound-N3 DMQFUCD MI TTWOH4Q DMQFUCD MN MERS-CoV 3C-like proteinase (3CLpro) DMQFUCD MT DTT DMQFUCD MA Inhibitor DMQFUCD RN Coronaviruses - drug discovery and therapeutic options. Nat Rev Drug Discov. 2016 May;15(5):327-47. DMQFUCD RU https://pubmed.ncbi.nlm.nih.gov/26868298 DMQFUCD DI DMQFUCD DMQFUCD DN PMID26868298-compound-N3 DMQFUCD MI TTPZG3C DMQFUCD MN SARS-CoV 3C-like protease (3CLpro) DMQFUCD MT DTT DMQFUCD MA Inhibitor DMQFUCD RN Coronaviruses - drug discovery and therapeutic options. Nat Rev Drug Discov. 2016 May;15(5):327-47. DMQFUCD RU https://pubmed.ncbi.nlm.nih.gov/26868298 DMUH012 DI DMUH012 DMUH012 DN PMID26911565-peptide-P9 DMUH012 MI TT85VHW DMUH012 MN MERS-CoV spike glycoprotein (S) DMUH012 MT DTT DMUH012 MA Inhibitor DMUH012 RN A novel peptide with potent and broad-spectrum antiviral activities against multiple respiratory viruses. Sci Rep. 2016 Feb 25;6:22008. DMUH012 RU https://pubmed.ncbi.nlm.nih.gov/26911565 DMUH012 DI DMUH012 DMUH012 DN PMID26911565-peptide-P9 DMUH012 MI TTTL19V DMUH012 MN SARS-CoV spike glycoprotein (S) DMUH012 MT DTT DMUH012 MA Inhibitor DMUH012 RN A novel peptide with potent and broad-spectrum antiviral activities against multiple respiratory viruses. Sci Rep. 2016 Feb 25;6:22008. DMUH012 RU https://pubmed.ncbi.nlm.nih.gov/26911565 DMPC29W DI DMPC29W DMPC29W DN PMID27240464-compound-3f DMPC29W MI TTWOH4Q DMPC29W MN MERS-CoV 3C-like proteinase (3CLpro) DMPC29W MT DTT DMPC29W MA Inhibitor DMPC29W RN Identification, synthesis and evaluation of SARS-CoV and MERS-CoV 3C-like protease inhibitors. Bioorg Med Chem. 2016 Jul 1;24(13):3035-3042. DMPC29W RU https://pubmed.ncbi.nlm.nih.gov/27240464 DMPC29W DI DMPC29W DMPC29W DN PMID27240464-compound-3f DMPC29W MI TTPZG3C DMPC29W MN SARS-CoV 3C-like protease (3CLpro) DMPC29W MT DTT DMPC29W MA Inhibitor DMPC29W RN Identification, synthesis and evaluation of SARS-CoV and MERS-CoV 3C-like protease inhibitors. Bioorg Med Chem. 2016 Jul 1;24(13):3035-3042. DMPC29W RU https://pubmed.ncbi.nlm.nih.gov/27240464 DMPWUFT DI DMPWUFT DMPWUFT DN PMID28216367-compound-6d DMPWUFT MI TTWOH4Q DMPWUFT MN MERS-CoV 3C-like proteinase (3CLpro) DMPWUFT MT DTT DMPWUFT MA Inhibitor DMPWUFT RN Identification and evaluation of potent Middle East respiratory syndrome coronavirus (MERS-CoV) 3CLPro inhibitors. Antiviral Res. 2017 May;141:101-106. DMPWUFT RU https://pubmed.ncbi.nlm.nih.gov/28216367 DMPWUFT DI DMPWUFT DMPWUFT DN PMID28216367-compound-6d DMPWUFT MI TTPZG3C DMPWUFT MN SARS-CoV 3C-like protease (3CLpro) DMPWUFT MT DTT DMPWUFT MA Inhibitor DMPWUFT RN Identification and evaluation of potent Middle East respiratory syndrome coronavirus (MERS-CoV) 3CLPro inhibitors. Antiviral Res. 2017 May;141:101-106. DMPWUFT RU https://pubmed.ncbi.nlm.nih.gov/28216367 DMYNCWK DI DMYNCWK DMYNCWK DN PMID28624700-compound-3-31 DMYNCWK MI TTPZG3C DMYNCWK MN SARS-CoV 3C-like protease (3CLpro) DMYNCWK MT DTT DMYNCWK MA Inhibitor DMYNCWK RN Discovery of Unsymmetrical Aromatic Disulfides as Novel Inhibitors of SARS-CoV Main Protease: Chemical Synthesis, Biological Evaluation, Molecular Docking and 3D-QSAR Study Eur J Med Chem. 2017 Sep 8;137:450-461. DMYNCWK RU https://pubmed.ncbi.nlm.nih.gov/28624700 DMVB0P3 DI DMVB0P3 DMVB0P3 DN PMID30784880-compound-6-5 DMVB0P3 MI TTPZG3C DMVB0P3 MN SARS-CoV 3C-like protease (3CLpro) DMVB0P3 MT DTT DMVB0P3 MA Inhibitor DMVB0P3 RN Chemical synthesis, crystal structure, versatile evaluation of their biological activities and molecular simulations of novel pyrithiobac derivatives. Eur J Med Chem. 2019 Apr 1;167:472-484. DMVB0P3 RU https://pubmed.ncbi.nlm.nih.gov/30784880 DMXCKL9 DI DMXCKL9 DMXCKL9 DN PMID30940566-compound-6 DMXCKL9 MI TTYJOLE DMXCKL9 MN MERS-CoV papain-like proteinase (PL-PRO) DMXCKL9 MT DTT DMXCKL9 MA Inhibitor DMXCKL9 RN Identification and Design of Novel Small Molecule Inhibitors Against MERS-CoV Papain-Like Protease via High-Throughput Screening and Molecular Modeling Bioorg Med Chem. 2019 May 15;27(10):1981-1989. DMXCKL9 RU https://pubmed.ncbi.nlm.nih.gov/30940566 DMZJWON DI DMZJWON DMZJWON DN PMID31244113-compound-2c DMZJWON MI TTOA6YT DMZJWON MN MERS-CoV RNA-directed RNA polymerase (RdRp) DMZJWON MT DTT DMZJWON MA Inhibitor DMZJWON RN Design, Synthesis, and Anti-RNA Virus Activity of 6'-Fluorinated-Aristeromycin Analogues. J Med Chem. 2019 Jul 11;62(13):6346-6362. DMZJWON RU https://pubmed.ncbi.nlm.nih.gov/31244113 DMZJWON DI DMZJWON DMZJWON DN PMID31244113-compound-2c DMZJWON MI TTKXI53 DMZJWON MN SARS-CoV RNA-directed RNA polymerase (RdRp) DMZJWON MT DTT DMZJWON MA Inhibitor DMZJWON RN Design, Synthesis, and Anti-RNA Virus Activity of 6'-Fluorinated-Aristeromycin Analogues. J Med Chem. 2019 Jul 11;62(13):6346-6362. DMZJWON RU https://pubmed.ncbi.nlm.nih.gov/31244113 DM9LS0R DI DM9LS0R DM9LS0R DN PMID31955138-compound-16 DM9LS0R MI TTY732E DM9LS0R MN MERS-CoV helicase (Hel) DM9LS0R MT DTT DM9LS0R MA Inhibitor DM9LS0R RN Design, synthesis and molecular docking of novel triazole derivatives as potential CoV helicase inhibitors. Acta Pharm. 2020 Jun 1;70(2):145-159. DM9LS0R RU https://pubmed.ncbi.nlm.nih.gov/31955138 DMMXR3L DI DMMXR3L DMMXR3L DN PMX205 DMMXR3L MI TTHXFA1 DMMXR3L MN C5a anaphylatoxin chemotactic receptor (C5AR1) DMMXR3L MT DTT DMMXR3L MA Antagonist DMMXR3L RN Development and validation of a LC-MS/MS assay for pharmacokinetic studies of complement C5a receptor antagonists PMX53 and PMX205 in mice. Sci Rep. 2018 May 25;8(1):8101. DMMXR3L RU https://pubmed.ncbi.nlm.nih.gov/29802264 DM9SY8E DI DM9SY8E DM9SY8E DN PT630 DM9SY8E MI TTDIGC1 DM9SY8E MN Dipeptidyl peptidase 4 (DPP-4) DM9SY8E MT DTT DM9SY8E MA Inhibitor DM9SY8E RN Targeting fibroblast activation protein inhibits tumor stromagenesis and growth in mice. J Clin Invest. 2009 Dec;119(12):3613-25. DM9SY8E RU https://pubmed.ncbi.nlm.nih.gov/19920354 DM9SY8E DI DM9SY8E DM9SY8E DN PT630 DM9SY8E MI TTGPQ0F DM9SY8E MN Prolyl endopeptidase FAP (FAP) DM9SY8E MT DTT DM9SY8E MA Inhibitor DM9SY8E RN Targeting fibroblast activation protein inhibits tumor stromagenesis and growth in mice. J Clin Invest. 2009 Dec;119(12):3613-25. DM9SY8E RU https://pubmed.ncbi.nlm.nih.gov/19920354 DMDKLB5 DI DMDKLB5 DMDKLB5 DN Puromycin DMDKLB5 MI DTI7UX6 DMDKLB5 MN Breast cancer resistance protein (ABCG2) DMDKLB5 MT DTP DMDKLB5 MA Substrate DMDKLB5 RN A prediction model of substrates and non-substrates of breast cancer resistance protein (BCRP) developed by GA-CG-SVM method. Comput Biol Med. 2011 Nov;41(11):1006-13. DMDKLB5 RU https://doi.org/10.1016/j.compbiomed.2011.08.009 DMDKLB5 DI DMDKLB5 DMDKLB5 DN Puromycin DMDKLB5 MI DTUGYRD DMDKLB5 MN P-glycoprotein 1 (ABCB1) DMDKLB5 MT DTP DMDKLB5 MA Substrate DMDKLB5 RN ATP-binding cassette transporters as pitfalls in selection of transgenic cells. Anal Biochem. 2010 Apr 15;399(2):246-50. DMDKLB5 RU https://doi.org/10.1016/j.ab.2009.12.014 DMLBFC0 DI DMLBFC0 DMLBFC0 DN Q-44287045 DMLBFC0 MI DEHD2Q8 DMLBFC0 MN Glycosyltransferase (Gtf) DMLBFC0 MT DME DMLBFC0 MA Metabolism DMLBFC0 RN A bacterial glycosyltransferase gene toolbox: generation and applications. Phytochemistry. 2009 Oct-Nov;70(15-16):1812-21. DMLBFC0 RU https://pubmed.ncbi.nlm.nih.gov/19559449 DMASVOD DI DMASVOD DMASVOD DN QSP DMASVOD MI DT9G7XN DMASVOD MN Peptide transporter 1 (SLC15A1) DMASVOD MT DTP DMASVOD MA Substrate DMASVOD RN Tripeptides of RS1 (RSC1A1) inhibit a monosaccharide-dependent exocytotic pathway of Na+-D-glucose cotransporter SGLT1 with high affinity. J Biol Chem. 2007 Sep 28;282(39):28501-13. DMASVOD RU http://www.ncbi.nlm.nih.gov/pubmed/17686765 DMRZBM7 DI DMRZBM7 DMRZBM7 DN RANBEZOLID HYDROCHLORIDE DMRZBM7 MI TTUWYEA DMRZBM7 MN Bacterial 50S ribosomal RNA (Bact 50S rRNA) DMRZBM7 MT DTT DMRZBM7 MA Modulator DMRZBM7 RN Mode of Action of Ranbezolid against Staphylococci and Structural Modeling Studies of Its Interaction with Ribosomes . Antimicrob Agents Chemother. 2009 April; 53(4): 1427-1433. DMRZBM7 RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2663096/ DM7JH0K DI DM7JH0K DM7JH0K DN RG70099 DM7JH0K MI TTZJYKH DM7JH0K MN Indoleamine 2,3-dioxygenase 1 (IDO1) DM7JH0K MT DTT DM7JH0K MA Inhibitor DM7JH0K RN Tryptophan metabolism as a common therapeutic target in cancer, neurodegeneration and beyond. Nat Rev Drug Discov. 2019 May;18(5):379-401. DM7JH0K RU https://pubmed.ncbi.nlm.nih.gov/30760888 DM7JH0K DI DM7JH0K DM7JH0K DN RG70099 DM7JH0K MI TTXNCBV DM7JH0K MN Tryptophan 2,3-dioxygenase (TDO) DM7JH0K MT DTT DM7JH0K MA Inhibitor DM7JH0K RN Tryptophan metabolism as a common therapeutic target in cancer, neurodegeneration and beyond. Nat Rev Drug Discov. 2019 May;18(5):379-401. DM7JH0K RU https://pubmed.ncbi.nlm.nih.gov/30760888 DMJGQD2 DI DMJGQD2 DMJGQD2 DN RMG-40083 DMJGQD2 MI TTLA931 DMJGQD2 MN Neuronal acetylcholine receptor alpha-7 (CHRNA7) DMJGQD2 MT DTT DMJGQD2 MA Antagonist DMJGQD2 RN The pipeline and future of drug development in schizophrenia. Mol Psychiatry. 2007 Oct;12(10):904-22. DMJGQD2 RU https://pubmed.ncbi.nlm.nih.gov/17667958 DMWAR1T DI DMWAR1T DMWAR1T DN Ro 61-8048 DMWAR1T MI TTIY56R DMWAR1T MN Kynurenine 3-hydroxylase (KMO) DMWAR1T MT DTT DMWAR1T MA Inhibitor DMWAR1T RN Modification of kynurenine pathway via inhibition of kynurenine hydroxylase attenuates surgical brain injury complications in a male rat model. J Neurosci Res. 2020 Jan;98(1):155-167. DMWAR1T RU https://pubmed.ncbi.nlm.nih.gov/31257634 DM3ZE5A DI DM3ZE5A DM3ZE5A DN RO-26-2853 DM3ZE5A MI TTLM12X DM3ZE5A MN Matrix metalloproteinase-2 (MMP-2) DM3ZE5A MT DTT DM3ZE5A MA Inhibitor DM3ZE5A RN Emerging disease-modifying therapies for the treatment of motor neuron disease/amyotropic lateral sclerosis. Expert Opin Emerg Drugs. 2007 May;12(2):229-52. DM3ZE5A RU https://pubmed.ncbi.nlm.nih.gov/17604499 DMF3YQZ DI DMF3YQZ DMF3YQZ DN Ro-27-3225 DMF3YQZ MI TTD0CIQ DMF3YQZ MN Melanocortin receptor 4 (MC4R) DMF3YQZ MT DTT DMF3YQZ MA Agonist DMF3YQZ RN Emerging drugs for obesity: linking novel biological mechanisms to pharmaceutical pipelines. Expert Opin Emerg Drugs. 2005 Aug;10(3):643-60. DMF3YQZ RU https://pubmed.ncbi.nlm.nih.gov/16083333 DMRT3FK DI DMRT3FK DMRT3FK DN RO5461111 DMRT3FK MI TTUMQVO DMRT3FK MN Cathepsin S (CTSS) DMRT3FK MT DTT DMRT3FK MA Inhibitor DMRT3FK RN Cathepsin S inhibition suppresses systemic lupus erythematosus and lupus nephritis because cathepsin S is essential for MHC class II-mediated CD4 T cell and B cell priming. Ann Rheum Dis. 2015 Feb;74(2):452-63. DMRT3FK RU https://pubmed.ncbi.nlm.nih.gov/24300027 DMZOUX4 DI DMZOUX4 DMZOUX4 DN Romazarit DMZOUX4 MI TTJ584C DMZOUX4 MN Peroxisome proliferator-activated receptor alpha (PPARA) DMZOUX4 MT DTT DMZOUX4 MA Modulator DMZOUX4 RN Fibrates as therapy for osteoarthritis and rheumatoid arthritis A systematic review. Ther Adv Musculoskelet Dis. 2013 February; 5(1): 33-44. DMZOUX4 RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3582306/ DMOQ63E DI DMOQ63E DMOQ63E DN Rottlerin DMOQ63E MI TTYVX59 DMOQ63E MN Protein kinase C (PRKC) DMOQ63E MT DTT DMOQ63E MA Inhibitor DMOQ63E RN Drugs used to treat Parkinson's disease, present status and future directions. CNS Neurol Disord Drug Targets. 2008 Oct;7(4):321-42. DMOQ63E RU https://pubmed.ncbi.nlm.nih.gov/18991661 DM89VIO DI DM89VIO DM89VIO DN RS2-1G9 DM89VIO MI TTM2AGN DM89VIO MN 3-oxo-dodecanoyl-homoserine lactone (C12) DM89VIO MT DTT DM89VIO MA Inhibitor DM89VIO RN Different drugs for bad bugs: antivirulence strategies in the age of antibiotic resistance. Nat Rev Drug Discov. 2017 Jul;16(7):457-471. DM89VIO RU https://pubmed.ncbi.nlm.nih.gov/28337021 DMB9IPR DI DMB9IPR DMB9IPR DN RS-504393 DMB9IPR MI TTFZYTO DMB9IPR MN C-C chemokine receptor type 2 (CCR2) DMB9IPR MT DTT DMB9IPR MA Antagonist DMB9IPR RN Beneficial or detrimental effects of carotenoids contained in food: cell culture models. Mini Rev Med Chem. 2007 Nov;7(11):1120-8. DMB9IPR RU https://pubmed.ncbi.nlm.nih.gov/18045215 DMB9IPR DI DMB9IPR DMB9IPR DN RS-504393 DMB9IPR MI TTNAY0P DMB9IPR MN Monocyte chemotactic and activating factor (CCL2) DMB9IPR MT DTT DMB9IPR MA Inhibitor DMB9IPR RN Privileged structures: a useful concept for the rational design of new lead drug candidates. Mini Rev Med Chem. 2007 Nov;7(11):1108-19. DMB9IPR RU https://pubmed.ncbi.nlm.nih.gov/18045214 DMH1FRY DI DMH1FRY DMH1FRY DN RWJ-416457 DMH1FRY MI TTGP7BY DMH1FRY MN Monoamine oxidase type B (MAO-B) DMH1FRY MT DTT DMH1FRY MA Inhibitor DMH1FRY RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2490). DMH1FRY RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2490 DMMVS07 DI DMMVS07 DMMVS07 DN RWJ-51204 DMMVS07 MI TTEX6LM DMMVS07 MN GABA(A) receptor gamma-3 (GABRG3) DMMVS07 MT DTT DMMVS07 MA Modulator DMMVS07 RN 5-ethoxymethyl-7-fluoro-3-oxo-1,2,3,5-tetrahydrobenzo[4,5]imidazo[1,2a]pyridine-4-N-(2-fluorophenyl)carboxamide (RWJ-51204), a new nonbenzodiazepine anxiolytic. J Pharmacol Exp Ther. 2002 Nov;303(2):777-90. DMMVS07 RU https://pubmed.ncbi.nlm.nih.gov/12388665 DM3AIQO DI DM3AIQO DM3AIQO DN RX-01-423 DM3AIQO MI TTUWYEA DM3AIQO MN Bacterial 50S ribosomal RNA (Bact 50S rRNA) DM3AIQO MT DTT DM3AIQO MA Modulator DM3AIQO RN DOI: 10.1038/nrd2202 DM3AIQO RU http://www.nature.com/nrd/journal/v6/n1/full/nrd2202.html DMXM2BZ DI DMXM2BZ DMXM2BZ DN Rycals DMXM2BZ MI TT5HONZ DMXM2BZ MN Calcium channel unspecific (CaC) DMXM2BZ MT DTT DMXM2BZ MA Modulator DMXM2BZ RN Fixing ryanodine receptor Ca2+ leak - a novel therapeutic strategy for contractile failure in heart and skeletal muscle. Drug Discov Today Dis Mech. 2010 SUMMER; 7(2): e151-e157. DMXM2BZ RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2989530/ DM9Y05C DI DM9Y05C DM9Y05C DN S-(2-Aminophenyl)-L-cysteine S,S-dioxide DM9Y05C MI TTWQM3J DM9Y05C MN Kynureninase (KYNU) DM9Y05C MT DTT DM9Y05C MA Inhibitor DM9Y05C RN Structure, mechanism, and substrate specificity of kynureninase. Biochim Biophys Acta. 2011 Nov;1814(11):1481-8. DM9Y05C RU https://pubmed.ncbi.nlm.nih.gov/21167323 DM4V8ZD DI DM4V8ZD DM4V8ZD DN S32504 DM4V8ZD MI TTEX248 DM4V8ZD MN Dopamine D2 receptor (D2R) DM4V8ZD MT DTT DM4V8ZD MA Modulator DM4V8ZD RN S32504, a novel naphtoxazine agonist at dopamine D3/D2 receptors: II. Actions in rodent, primate, and cellular models of antiparkinsonian activity ... J Pharmacol Exp Ther. 2004 Jun;309(3):921-35. DM4V8ZD RU https://pubmed.ncbi.nlm.nih.gov/14978195 DM4V8ZD DI DM4V8ZD DM4V8ZD DN S32504 DM4V8ZD MI TT4C8EA DM4V8ZD MN Dopamine D3 receptor (D3R) DM4V8ZD MT DTT DM4V8ZD MA Modulator DM4V8ZD RN S32504, a novel naphtoxazine agonist at dopamine D3/D2 receptors: II. Actions in rodent, primate, and cellular models of antiparkinsonian activity ... J Pharmacol Exp Ther. 2004 Jun;309(3):921-35. DM4V8ZD RU https://pubmed.ncbi.nlm.nih.gov/14978195 DMWQ3TH DI DMWQ3TH DMWQ3TH DN S-33084 DMWQ3TH MI TT4C8EA DMWQ3TH MN Dopamine D3 receptor (D3R) DMWQ3TH MT DTT DMWQ3TH MA Modulator DMWQ3TH RN S33084, a novel, potent, selective, and competitive antagonist at dopamine D(3)-receptors: II. Functional and behavioral profile compared with GR218,231 and L741,626. J Pharmacol Exp Ther. 2000 Jun;293(3):1063-73. DMWQ3TH RU https://pubmed.ncbi.nlm.nih.gov/10869411 DMGXVRZ DI DMGXVRZ DMGXVRZ DN Salicylihalamide A DMGXVRZ MI TTTK3BH DMGXVRZ MN Vacuolar-type proton ATPase (v-ATPase) DMGXVRZ MT DTT DMGXVRZ MA Inhibitor DMGXVRZ RN Discovery of a novel antitumor benzolactone enamide class that selectively inhibits mammalian vacuolar-type (H+)-atpases. J Pharmacol Exp Ther. 2001 Apr;297(1):114-20. DMGXVRZ RU https://pubmed.ncbi.nlm.nih.gov/11259534 DMLMRGH DI DMLMRGH DMLMRGH DN Saliphenylhalamide DMLMRGH MI TTF1QVM DMLMRGH MN Gastric H(+)/K(+) ATPase alpha (ATP4A) DMLMRGH MT DTT DMLMRGH MA Inhibitor DMLMRGH RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 849). DMLMRGH RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=849 DM7E324 DI DM7E324 DM7E324 DN SAND-5 DM7E324 MI TTKANGO DM7E324 MN Complement C5 (CO5) DM7E324 MT DTT DM7E324 MA Inhibitor DM7E324 RN Progress and Trends in Complement Therapeutics. Adv Exp Med Biol. 2013; 734: 1-22. DM7E324 RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3526805/ DM7NS1L DI DM7NS1L DM7NS1L DN Savirin DM7NS1L MI TTWPX3M DM7NS1L MN Staphylococcus Accessory gene regulator protein A (Stap-coc agrA) DM7NS1L MT DTT DM7NS1L MA Inhibitor DM7NS1L RN Selective chemical inhibition of agr quorum sensing in Staphylococcus aureus promotes host defense with minimal impact on resistance. PLoS Pathog. 2014 Jun 12;10(6):e1004174. DM7NS1L RU https://pubmed.ncbi.nlm.nih.gov/24945495 DMFXJDL DI DMFXJDL DMFXJDL DN SB 242784 DMFXJDL MI TTTK3BH DMFXJDL MN Vacuolar-type proton ATPase (v-ATPase) DMFXJDL MT DTT DMFXJDL MA Inhibitor DMFXJDL RN SB 242784, a selective inhibitor of the osteoclastic V-H+ATPase, inhibits arterial calcification in the rat. Circ Res. 2002 Sep 20;91(6):547-52. DMFXJDL RU https://pubmed.ncbi.nlm.nih.gov/12242274 DM6X0PZ DI DM6X0PZ DM6X0PZ DN SB222200 DM6X0PZ MI TTBPGLU DM6X0PZ MN Neuromedin-K receptor (TACR3) DM6X0PZ MT DTT DM6X0PZ MA Antagonist DM6X0PZ RN Evidence for mediation of nociception by injection of the NK-3 receptor agonist, senktide, into the dorsal periaqueductal gray of rats. Psychopharmacology (Berl). 2009 May;204(1):13-24. DM6X0PZ RU https://pubmed.ncbi.nlm.nih.gov/19093101 DM0YOXQ DI DM0YOXQ DM0YOXQ DN SB-431542 DM0YOXQ MI TTP4520 DM0YOXQ MN TGF-beta receptor type I (TGFBR1) DM0YOXQ MT DTT DM0YOXQ MA Inhibitor DM0YOXQ RN Pyrazolone based TGFbetaR1 kinase inhibitors. Bioorg Med Chem Lett. 2010 Jan 1;20(1):326-9. DM0YOXQ RU https://pubmed.ncbi.nlm.nih.gov/19914068 DMXN4UC DI DMXN4UC DMXN4UC DN SBX-101 DMXN4UC MI TTQALFH DMXN4UC MN Bacterial Beta-glucuronidase (Bact uidA) DMXN4UC MT DTT DMXN4UC MA Inhibitor DMXN4UC RN Microbiome therapeutics go small molecule. Nat Rev Drug Discov. 2019 Jul;18(8):569-572. DMXN4UC RU https://pubmed.ncbi.nlm.nih.gov/31367062 DMLG682 DI DMLG682 DMLG682 DN SCH-1359113 DMLG682 MI TT8JRS7 DMLG682 MN Beta-secretase (BACE) DMLG682 MT DTT DMLG682 MA Inhibitor DMLG682 RN ACS Meeting News: Using chemistry tools to refine an Alzheimer's drug candidate. C&EN. April 5, 2010. Volume 88, Number 14 p.14. DMLG682 RU https://pubs.acs.org/cen/coverstory/88/8814cover1.html DM9JZ21 DI DM9JZ21 DM9JZ21 DN Scriptaid DM9JZ21 MI TT6R7JZ DM9JZ21 MN Histone deacetylase 1 (HDAC1) DM9JZ21 MT DTT DM9JZ21 MA Inhibitor DM9JZ21 RN Histone deacetylase inhibitors in cancer therapy: latest developments, trends and medicinal chemistry perspective. Anticancer Agents Med Chem. 2007 Sep;7(5):576-92. DM9JZ21 RU https://pubmed.ncbi.nlm.nih.gov/17896917 DMJT1E5 DI DMJT1E5 DMJT1E5 DN Scutellarin DMJT1E5 MI DTI7UX6 DMJT1E5 MN Breast cancer resistance protein (ABCG2) DMJT1E5 MT DTP DMJT1E5 MA Substrate DMJT1E5 RN Mechanistic studies on the absorption and disposition of scutellarin in humans: selective OATP2B1-mediated hepatic uptake is a likely key determinant for its unique pharmacokinetic characteristics. Drug Metab Dispos. 2012 Oct;40(10):2009-20. DMJT1E5 RU https://doi.org/10.1124/dmd.112.047183 DMJT1E5 DI DMJT1E5 DMJT1E5 DN Scutellarin DMJT1E5 MI DTFI42L DMJT1E5 MN Multidrug resistance-associated protein 2 (ABCC2) DMJT1E5 MT DTP DMJT1E5 MA Substrate DMJT1E5 RN Mechanistic studies on the absorption and disposition of scutellarin in humans: selective OATP2B1-mediated hepatic uptake is a likely key determinant for its unique pharmacokinetic characteristics. Drug Metab Dispos. 2012 Oct;40(10):2009-20. DMJT1E5 RU https://doi.org/10.1124/dmd.112.047183 DMJT1E5 DI DMJT1E5 DMJT1E5 DN Scutellarin DMJT1E5 MI DTQ3ZHF DMJT1E5 MN Multidrug resistance-associated protein 3 (ABCC3) DMJT1E5 MT DTP DMJT1E5 MA Substrate DMJT1E5 RN Mechanistic studies on the absorption and disposition of scutellarin in humans: selective OATP2B1-mediated hepatic uptake is a likely key determinant for its unique pharmacokinetic characteristics. Drug Metab Dispos. 2012 Oct;40(10):2009-20. DMJT1E5 RU https://doi.org/10.1124/dmd.112.047183 DMJT1E5 DI DMJT1E5 DMJT1E5 DN Scutellarin DMJT1E5 MI DTPFTEQ DMJT1E5 MN Organic anion transporting polypeptide 2B1 (SLCO2B1) DMJT1E5 MT DTP DMJT1E5 MA Substrate DMJT1E5 RN Mechanistic studies on the absorption and disposition of scutellarin in humans: selective OATP2B1-mediated hepatic uptake is a likely key determinant for its unique pharmacokinetic characteristics. Drug Metab Dispos. 2012 Oct;40(10):2009-20. DMJT1E5 RU https://doi.org/10.1124/dmd.112.047183 DMELFBU DI DMELFBU DMELFBU DN SCY-641 DMELFBU MI TTATDGJ DMELFBU MN Calcium signal-modulating cyclophilin ligand (CAML) DMELFBU MT DTT DMELFBU MA Inhibitor DMELFBU RN 2011 Pipeline of SCYNEXIS. DMELFBU RU http://www.scynexis.com/pipeline/ DMLAF6C DI DMLAF6C DMLAF6C DN SD1002 DMLAF6C MI TTF2LRI DMLAF6C MN Cathepsin B (CTSB) DMLAF6C MT DTT DMLAF6C MA Inhibitor DMLAF6C RN Lysosomes as a therapeutic target. Nat Rev Drug Discov. 2019 Dec;18(12):923-948. DMLAF6C RU https://pubmed.ncbi.nlm.nih.gov/31477883 DMLAF6C DI DMLAF6C DMLAF6C DN SD1002 DMLAF6C MI TT36ETB DMLAF6C MN Cathepsin L (CTSL) DMLAF6C MT DTT DMLAF6C MA Inhibitor DMLAF6C RN Lysosomes as a therapeutic target. Nat Rev Drug Discov. 2019 Dec;18(12):923-948. DMLAF6C RU https://pubmed.ncbi.nlm.nih.gov/31477883 DM29BW1 DI DM29BW1 DM29BW1 DN SD1003 DM29BW1 MI TTF2LRI DM29BW1 MN Cathepsin B (CTSB) DM29BW1 MT DTT DM29BW1 MA Inhibitor DM29BW1 RN Lysosomes as a therapeutic target. Nat Rev Drug Discov. 2019 Dec;18(12):923-948. DM29BW1 RU https://pubmed.ncbi.nlm.nih.gov/31477883 DM29BW1 DI DM29BW1 DM29BW1 DN SD1003 DM29BW1 MI TT36ETB DM29BW1 MN Cathepsin L (CTSL) DM29BW1 MT DTT DM29BW1 MA Inhibitor DM29BW1 RN Lysosomes as a therapeutic target. Nat Rev Drug Discov. 2019 Dec;18(12):923-948. DM29BW1 RU https://pubmed.ncbi.nlm.nih.gov/31477883 DM5LU3N DI DM5LU3N DM5LU3N DN Selamectin DM5LU3N MI DTUGYRD DM5LU3N MN P-glycoprotein 1 (ABCB1) DM5LU3N MT DTP DM5LU3N MA Substrate DM5LU3N RN Interaction of macrocyclic lactones with P-glycoprotein: structure-affinity relationship. Eur J Pharm Sci. 2007 Jan;30(1):84-94. DM5LU3N RU https://doi.org/10.1016/j.ejps.2006.10.004 DMH1WNI DI DMH1WNI DMH1WNI DN SGN-19A DMH1WNI MI TTW640A DMH1WNI MN B-lymphocyte surface antigen B4 (CD19) DMH1WNI MT DTT DMH1WNI RN 2011 Pipeline of Seattle Genetics. DMH1WNI RU http://www.seagen.com/product_pipeline.php DMHAONP DI DMHAONP DMHAONP DN SHP-627 DMHAONP MI TTO3HT7 DMHAONP MN Transforming growth factor beta (TGFB) DMHAONP MT DTT DMHAONP MA Inhibitor DMHAONP RN Drugs and Targets in Fibrosis. Front Pharmacol. 2017 Nov 23;8:855. DMHAONP RU https://pubmed.ncbi.nlm.nih.gov/29218009 DM8DYJQ DI DM8DYJQ DM8DYJQ DN SHP656 DM8DYJQ MI TT5MLZR DM8DYJQ MN Cryptochrome circadian clock 1 (CRY1) DM8DYJQ MT DTT DM8DYJQ MA Modulator DM8DYJQ RN Circadian rhythm as a therapeutic target. Nat Rev Drug Discov. 2021 Apr;20(4):287-307. DM8DYJQ RU https://pubmed.ncbi.nlm.nih.gov/33589815 DM8DYJQ DI DM8DYJQ DM8DYJQ DN SHP656 DM8DYJQ MI TTAO58M DM8DYJQ MN Cryptochrome-2 (CRY2) DM8DYJQ MT DTT DM8DYJQ MA Modulator DM8DYJQ RN Circadian rhythm as a therapeutic target. Nat Rev Drug Discov. 2021 Apr;20(4):287-307. DM8DYJQ RU https://pubmed.ncbi.nlm.nih.gov/33589815 DMWBCTA DI DMWBCTA DMWBCTA DN SIS-3 DMWBCTA MI TTHQZV7 DMWBCTA MN Mothers against decapentaplegic homolog 3 (SMAD3) DMWBCTA MT DTT DMWBCTA MA Inhibitor DMWBCTA RN Characterization of SIS3, a novel specific inhibitor of Smad3, and its effect on transforming growth factor-beta1-induced extracellular matrix expression. Mol Pharmacol. 2006 Feb;69(2):597-607. DMWBCTA RU https://pubmed.ncbi.nlm.nih.gov/16288083 DM7DNOG DI DM7DNOG DM7DNOG DN SK-7041 DM7DNOG MI TT6R7JZ DM7DNOG MN Histone deacetylase 1 (HDAC1) DM7DNOG MT DTT DM7DNOG MA Inhibitor DM7DNOG RN Histone deacetylase inhibitors in cancer therapy: latest developments, trends and medicinal chemistry perspective. Anticancer Agents Med Chem. 2007 Sep;7(5):576-92. DM7DNOG RU https://pubmed.ncbi.nlm.nih.gov/17896917 DMCI371 DI DMCI371 DMCI371 DN SK-7068 DMCI371 MI TT6R7JZ DMCI371 MN Histone deacetylase 1 (HDAC1) DMCI371 MT DTT DMCI371 MA Inhibitor DMCI371 RN Histone deacetylase inhibitors in cancer therapy: latest developments, trends and medicinal chemistry perspective. Anticancer Agents Med Chem. 2007 Sep;7(5):576-92. DMCI371 RU https://pubmed.ncbi.nlm.nih.gov/17896917 DMY9DA3 DI DMY9DA3 DMY9DA3 DN SLV-332 DMY9DA3 MI TTYO0A3 DMY9DA3 MN Substance-K receptor (TACR2) DMY9DA3 MT DTT DMY9DA3 MA Antagonist DMY9DA3 RN Emerging drugs for irritable bowel syndrome. Expert Opin Emerg Drugs. 2006 May;11(2):293-313. DMY9DA3 RU https://pubmed.ncbi.nlm.nih.gov/16634703 DM3X4JL DI DM3X4JL DM3X4JL DN SMITB14 DM3X4JL MI TT3V4L8 DM3X4JL MN Mycobacterial lipoarabinomannan (MycB LAM) DM3X4JL MT DTT DM3X4JL MA Inhibitor DM3X4JL RN Different drugs for bad bugs: antivirulence strategies in the age of antibiotic resistance. Nat Rev Drug Discov. 2017 Jul;16(7):457-471. DM3X4JL RU https://pubmed.ncbi.nlm.nih.gov/28337021 DM5KE4R DI DM5KE4R DM5KE4R DN SNAP-7941 DM5KE4R MI TTX4RTB DM5KE4R MN Melanin-concentrating hormone receptor 1 (MCHR1) DM5KE4R MT DTT DM5KE4R MA Antagonist DM5KE4R RN Emerging drugs for obesity: linking novel biological mechanisms to pharmaceutical pipelines. Expert Opin Emerg Drugs. 2005 Aug;10(3):643-60. DM5KE4R RU https://pubmed.ncbi.nlm.nih.gov/16083333 DMSNX4O DI DMSNX4O DMSNX4O DN SoRI-9409 DMSNX4O MI TT27RFC DMSNX4O MN Opioid receptor delta (OPRD1) DMSNX4O MT DTT DMSNX4O MA Antagonist DMSNX4O RN In vivo pharmacological characterization of SoRI 9409, a nonpeptidic opioid mu-agonist/delta-antagonist that produces limited antinociceptive tolerance and attenuates morphine physical dependence. J Pharmacol Exp Ther. 2001 May;297(2):597-605. DMSNX4O RU https://pubmed.ncbi.nlm.nih.gov/11303048 DMJHWYP DI DMJHWYP DMJHWYP DN Spautin 1 DMJHWYP MI TT5IH09 DMJHWYP MN Ubiquitin carboxyl-terminal hydrolase 10 (USP10) DMJHWYP MT DTT DMJHWYP MA Inhibitor DMJHWYP RN Potent USP10/13 antagonist spautin-1 suppresses melanoma growth via ROS-mediated DNA damage and exhibits synergy with cisplatin. J Cell Mol Med. 2020 Apr;24(7):4324-4340. DMJHWYP RU https://pubmed.ncbi.nlm.nih.gov/32129945 DMJHWYP DI DMJHWYP DMJHWYP DN Spautin 1 DMJHWYP MI TTVJIO2 DMJHWYP MN Ubiquitin carboxyl-terminal hydrolase 13 (USP13) DMJHWYP MT DTT DMJHWYP MA Inhibitor DMJHWYP RN Potent USP10/13 antagonist spautin-1 suppresses melanoma growth via ROS-mediated DNA damage and exhibits synergy with cisplatin. J Cell Mol Med. 2020 Apr;24(7):4324-4340. DMJHWYP RU https://pubmed.ncbi.nlm.nih.gov/32129945 DMMA2ZW DI DMMA2ZW DMMA2ZW DN SPH-1285 DMMA2ZW MI TT1RS9F DMMA2ZW MN Acetylcholinesterase (AChE) DMMA2ZW MT DTT DMMA2ZW MA Inhibitor DMMA2ZW RN Galantamine, a cholinesterase inhibitor that allosterically modulates nicotinic receptors: effects on the course of Alzheimer's disease. Biol Psychiatry. 2001 Feb 1;49(3):289-99. DMMA2ZW RU https://pubmed.ncbi.nlm.nih.gov/11230880 DM32NMB DI DM32NMB DM32NMB DN S-Phenyl-L-cysteine sulfoxide DM32NMB MI TTLQ3OP DM32NMB MN Pseudomonas Kynureninase (Pseudo kynU) DM32NMB MT DTT DM32NMB MA Inhibitor DM32NMB RN Chemical Inhibition of Kynureninase Reduces Pseudomonas aeruginosa Quorum Sensing and Virulence Factor Expression. ACS Chem Biol. 2016 Apr 15;11(4):1106-17. DM32NMB RU https://pubmed.ncbi.nlm.nih.gov/26785289 DMYZQKC DI DMYZQKC DMYZQKC DN SPHINX31 DMYZQKC MI TTU3WV6 DMYZQKC MN SRSF protein kinase 1 (SRPK1) DMYZQKC MT DTT DMYZQKC MA Inhibitor DMYZQKC RN Kinase inhibitors: the road ahead. 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DM7MDZE RU https://pubmed.ncbi.nlm.nih.gov/20735016 DM7MDZE DI DM7MDZE DM7MDZE DN SR1078 DM7MDZE MI TTGV6LY DM7MDZE MN Nuclear receptor ROR-gamma (RORG) DM7MDZE MT DTT DM7MDZE MA Agonist DM7MDZE RN Identification of SR1078, a synthetic agonist for the orphan nuclear receptors RORalpha and ROR. ACS Chem Biol. 2010 Nov 19;5(11):1029-34. DM7MDZE RU https://pubmed.ncbi.nlm.nih.gov/20735016 DMZV9JX DI DMZV9JX DMZV9JX DN SR1555 DMZV9JX MI TTGV6LY DMZV9JX MN Nuclear receptor ROR-gamma (RORG) DMZV9JX MT DTT DMZV9JX MA Agonist DMZV9JX RN Circadian rhythm as a therapeutic target. Nat Rev Drug Discov. 2021 Apr;20(4):287-307. DMZV9JX RU https://pubmed.ncbi.nlm.nih.gov/33589815 DMWCBG8 DI DMWCBG8 DMWCBG8 DN SR2211 DMWCBG8 MI TTGV6LY DMWCBG8 MN Nuclear receptor ROR-gamma (RORG) DMWCBG8 MT DTT DMWCBG8 MA Agonist DMWCBG8 RN Circadian rhythm as a therapeutic target. Nat Rev Drug Discov. 2021 Apr;20(4):287-307. 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Adis Insight (drug id 800032947) DMB7WEY RU http://adisinsight.springer.com/drugs/800032947 DMRGZQA DI DMRGZQA DMRGZQA DN TZP-202 DMRGZQA MI TT953CX DMRGZQA MN Motilin receptor (MLNR) DMRGZQA MT DTT DMRGZQA MA Antagonist DMRGZQA RN Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800023009) DMRGZQA RU http://adisinsight.springer.com/drugs/800023009 DME8AL0 DI DME8AL0 DME8AL0 DN TZP-301 DME8AL0 MI TTWDC17 DME8AL0 MN Growth hormone secretagogue receptor 1 (GHSR) DME8AL0 MT DTT DME8AL0 MA Antagonist DME8AL0 RN Clinical pipeline report, company report or official report of Tranzyme Pharma (2011). DME8AL0 RU http://www.tranzyme.com/products DMW87JR DI DMW87JR DMW87JR DN U-99194A DMW87JR MI TT4C8EA DMW87JR MN Dopamine D3 receptor (D3R) DMW87JR MT DTT DMW87JR MA Binder DMW87JR RN The pipeline and future of drug development in schizophrenia. 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DMQG2EY RU https://pubmed.ncbi.nlm.nih.gov/17283330 DMJDT5O DI DMJDT5O DMJDT5O DN VIS513 DMJDT5O MI TTMYZNX DMJDT5O MN Dengue virus Envelope (DENV E) DMJDT5O MT DTT DMJDT5O MA Inhibitor DMJDT5O RN Neutralization of antibody-enhanced dengue infection by VIS513, a pan serotype reactive monoclonal antibody targeting domain III of the dengue E protein. PLoS Negl Trop Dis. 2018 Feb 9;12(2):e0006209. DMJDT5O RU https://pubmed.ncbi.nlm.nih.gov/29425203 DMZHAVG DI DMZHAVG DMZHAVG DN VPM-4-001 DMZHAVG MI TT93WF5 DMZHAVG MN Interferon-gamma (IFNG) DMZHAVG MT DTT DMZHAVG RN BioPartnering North America--Programs from Pharma in Europe and the Middle East. IDrugs. 2010 Mar;13(3):162-5. DMZHAVG RU https://pubmed.ncbi.nlm.nih.gov/20191431 DMZHAVG DI DMZHAVG DMZHAVG DN VPM-4-001 DMZHAVG MI TTF89GD DMZHAVG MN Interleukin-2 (IL2) DMZHAVG MT DTT DMZHAVG RN BioPartnering North America--Programs from Pharma in Europe and the Middle East. IDrugs. 2010 Mar;13(3):162-5. 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DMD8TNK RU http://www.exelixis.com/pipeline DMINSA5 DI DMINSA5 DMINSA5 DN XL-499 DMINSA5 MI TTGBPJE DMINSA5 MN PI3-kinase delta (PIK3CD) DMINSA5 MT DTT DMINSA5 MA Inhibitor DMINSA5 RN Clinical pipeline report, company report or official report of Exelixis. DMINSA5 RU http://www.exelixis.com/pipeline/xl499 DMU86XT DI DMU86XT DMU86XT DN YM-201636 DMU86XT MI TTA4M1N DMU86XT MN Phosphatidylinositol-3-phosphate 5-kinase (PIP5K3) DMU86XT MT DTT DMU86XT MA Inhibitor DMU86XT RN PIKfyve negatively regulates exocytosis in neurosecretory cells. J Biol Chem. 2008 Feb 1;283(5):2804-13. DMU86XT RU https://pubmed.ncbi.nlm.nih.gov/18039667 DMMUYC2 DI DMMUYC2 DMMUYC2 DN YM-344031 DMMUYC2 MI TTD3XFU DMMUYC2 MN C-C chemokine receptor type 3 (CCR3) DMMUYC2 MT DTT DMMUYC2 MA Antagonist DMMUYC2 RN Emerging drugs for asthma. Expert Opin Emerg Drugs. 2008 Dec;13(4):643-53. DMMUYC2 RU https://pubmed.ncbi.nlm.nih.gov/19046132 DMTM1LK DI DMTM1LK DMTM1LK DN YM-355179 DMTM1LK MI TTD3XFU DMTM1LK MN C-C chemokine receptor type 3 (CCR3) DMTM1LK MT DTT DMTM1LK MA Antagonist DMTM1LK RN Emerging drugs for asthma. Expert Opin Emerg Drugs. 2008 Dec;13(4):643-53. DMTM1LK RU https://pubmed.ncbi.nlm.nih.gov/19046132 DMH0I9N DI DMH0I9N DMH0I9N DN YW327.6S2 DMH0I9N MI TTZPY6J DMH0I9N MN Tyrosine-protein kinase UFO (AXL) DMH0I9N MT DTT DMH0I9N RN AXL receptor tyrosine kinase as a promising anti-cancer approach: functions, molecular mechanisms and clinical applications. Mol Cancer. 2019 Nov 4;18(1):153. DMH0I9N RU https://pubmed.ncbi.nlm.nih.gov/31684958 DMDRQIA DI DMDRQIA DMDRQIA DN ZBzl-YAA5911 DMDRQIA MI TTZXI0P DMDRQIA MN Enterococcus fsrC (Ente-cocc fsrC) DMDRQIA MT DTT DMDRQIA MA Antagonist DMDRQIA RN Different drugs for bad bugs: antivirulence strategies in the age of antibiotic resistance. Nat Rev Drug Discov. 2017 Jul;16(7):457-471. DMDRQIA RU https://pubmed.ncbi.nlm.nih.gov/28337021 DMNG84V DI DMNG84V DMNG84V DN ZK-thiazolidinone DMNG84V MI TTIYVQP DMNG84V MN Polo-like kinase 1 (PLK1) DMNG84V MT DTT DMNG84V MA Inhibitor DMNG84V RN Polo-like kinase (PLK) inhibitors in preclinical and early clinical development in oncology. Oncologist. 2009 Jun;14(6):559-70. DMNG84V RU https://pubmed.ncbi.nlm.nih.gov/19474163 DMX23CZ DI DMX23CZ DMX23CZ DN Z-Phe-Ala-diazomethylketone DMX23CZ MI TTF2LRI DMX23CZ MN Cathepsin B (CTSB) DMX23CZ MT DTT DMX23CZ MA Inhibitor DMX23CZ RN Lysosomes as a therapeutic target. Nat Rev Drug Discov. 2019 Dec;18(12):923-948. DMX23CZ RU https://pubmed.ncbi.nlm.nih.gov/31477883 DMX23CZ DI DMX23CZ DMX23CZ DN Z-Phe-Ala-diazomethylketone DMX23CZ MI TT36ETB DMX23CZ MN Cathepsin L (CTSL) DMX23CZ MT DTT DMX23CZ MA Inhibitor DMX23CZ RN Lysosomes as a therapeutic target. Nat Rev Drug Discov. 2019 Dec;18(12):923-948. DMX23CZ RU https://pubmed.ncbi.nlm.nih.gov/31477883 DMTDG7L DI DMTDG7L DMTDG7L DN Z-VAD-fmk DMTDG7L MI TTZY5KP DMTDG7L MN Caspase (CASP) DMTDG7L MT DTT DMTDG7L MA Inhibitor DMTDG7L RN Clinical pipeline report, company report or official report of InvivoGen. DMTDG7L RU https://www.invivogen.com/z-vad-fmk DMVO0LU DI DMVO0LU DMVO0LU DN 131I-81C6 DMVO0LU MI TTUCPMY DMVO0LU MN Tenascin (TNC) DMVO0LU MT DTT DMVO0LU RN Human IgG2 constant region enhances in vivo stability of anti-tenascin antibody 81C6 compared with its murine parent. Clin Cancer Res. 1998 Oct;4(10):2495-502. DMVO0LU RU https://pubmed.ncbi.nlm.nih.gov/9796983 DMTH52F DI DMTH52F DMTH52F DN 21-AMINOEPOTHILONE B DMTH52F MI TTML2WA DMTH52F MN Tubulin (TUB) DMTH52F MT DTT DMTH52F MA Inhibitor DMTH52F RN Tubulin-Interactive Natural Products as Anticancer Agents. Correction in: J Nat Prod. 2011 May 27; 74(5): 1352. DMTH52F RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2765517/ DMO6BA0 DI DMO6BA0 DMO6BA0 DN 3-DEAZAADENOSINE DMO6BA0 MI TTANY71 DMO6BA0 MN AdoHcy hydrolase (SAHase) DMO6BA0 MT DTT DMO6BA0 MA Modulator DMO6BA0 RN Anti-HIV-1 activity of 3-deaza-adenosine analogs. Inhibition of S-adenosylhomocysteine hydrolase and nucleotide congeners. Eur J Biochem. 2003 Sep;270(17):3507-17. DMO6BA0 RU https://pubmed.ncbi.nlm.nih.gov/12919315 DMQ4X7Y DI DMQ4X7Y DMQ4X7Y DN 443C81 DMQ4X7Y MI TTKWM86 DMQ4X7Y MN Opioid receptor mu (MOP) DMQ4X7Y MT DTT DMQ4X7Y MA Modulator DMQ4X7Y RN Inhibition of cholinergic neurotransmission in human airways by opioids. J Appl Physiol (1985). 1992 Mar;72(3):1096-100. DMQ4X7Y RU https://pubmed.ncbi.nlm.nih.gov/1314798 DMM3UK5 DI DMM3UK5 DMM3UK5 DN 50-235 DMM3UK5 MI TTKRD0G DMM3UK5 MN Endothelin A receptor (EDNRA) DMM3UK5 MT DTT DMM3UK5 MA Modulator DMM3UK5 RN Structure-activity relationships of an endothelin ETA receptor antagonist, 50-235, and its derivatives. Eur J Pharmacol. 1993 Oct 15;247(2):219-21. DMM3UK5 RU https://pubmed.ncbi.nlm.nih.gov/8282010 DM5MVF9 DI DM5MVF9 DM5MVF9 DN 6-nitroquipazine DM5MVF9 MI TT3ROYC DM5MVF9 MN Serotonin transporter (SERT) DM5MVF9 MT DTT DM5MVF9 MA Inhibitor DM5MVF9 RN Syntheses and binding affinities of 6-nitroquipazine analogues for serotonin transporter. Part 5: 2'-Substituted 6-nitroquipazines. Bioorg Med Chem. 2007 May 15;15(10):3499-504. DM5MVF9 RU https://pubmed.ncbi.nlm.nih.gov/17376695 DMX5K4C DI DMX5K4C DMX5K4C DN 7-methoxytacrine DMX5K4C MI TT1RS9F DMX5K4C MN Acetylcholinesterase (AChE) DMX5K4C MT DTT DMX5K4C MA Inhibitor DMX5K4C RN Synthesis and in vitro evaluation of N-alkyl-7-methoxytacrine hydrochlorides as potential cholinesterase inhibitors in Alzheimer disease. Bioorg Med Chem Lett. 2010 Oct 15;20(20):6093-5. DMX5K4C RU https://pubmed.ncbi.nlm.nih.gov/20817518 DM0NY6K DI DM0NY6K DM0NY6K DN A 77636 DM0NY6K MI TTZFYLI DM0NY6K MN Dopamine D1 receptor (D1R) DM0NY6K MT DTT DM0NY6K MA Modulator DM0NY6K RN Actions of the D1 agonists A-77636 and A-86929 on locomotion and dyskinesia in MPTP-treated L-dopa-primed common marmosets. Psychopharmacology (Berl). 1999 Feb;142(1):51-60. DM0NY6K RU https://www.ncbi.nlm.nih.gov/pubmed/10102782 DMZ5NQP DI DMZ5NQP DMZ5NQP DN A-11259 DMZ5NQP MI TT3C1VN DMZ5NQP MN Enzyme unspecific (Enz) DMZ5NQP MT DTT DMZ5NQP MA Inhibitor DMZ5NQP RN The Identification of Nanomolar 1,4-benzoquinone Inhibitors of Shikimate Kinase. Aspergillus & Aspergillosis Website. 2002. DMZ5NQP RU http://www.aspergillus.org.uk/content/identification-nanomolar-14-benzoquinone-inhibitors-shikimate-kinase DM6CSRU DI DM6CSRU DM6CSRU DN A-131701 DM6CSRU MI TTNGILX DM6CSRU MN Adrenergic receptor alpha-1A (ADRA1A) DM6CSRU MT DTT DM6CSRU MA Inhibitor DM6CSRU RN Pharmacophore identification of alpha(1A)-adrenoceptor antagonists. Bioorg Med Chem Lett. 2005 Feb 1;15(3):657-64. DM6CSRU RU https://pubmed.ncbi.nlm.nih.gov/15664832 DMRWDX5 DI DMRWDX5 DMRWDX5 DN A-134974 DMRWDX5 MI TTL732K DMRWDX5 MN Adenosine kinase (ADK) DMRWDX5 MT DTT DMRWDX5 MA Inhibitor DMRWDX5 RN Effects of A-134974, a novel adenosine kinase inhibitor, on carrageenan-induced inflammatory hyperalgesia and locomotor activity in rats: evaluation of the sites of action. J Pharmacol Exp Ther. 2001Feb;296(2):501-9. DMRWDX5 RU https://pubmed.ncbi.nlm.nih.gov/11160637 DMPEJ4O DI DMPEJ4O DMPEJ4O DN A-204176 DMPEJ4O MI TTNGILX DMPEJ4O MN Adrenergic receptor alpha-1A (ADRA1A) DMPEJ4O MT DTT DMPEJ4O MA Agonist DMPEJ4O RN Pharmacological properties of A-204176, a novel and selective alpha1A adrenergic agonist, in in vitro and in vivo models of urethral function. Life Sci. 2001 Nov 30;70(2):181-97. DMPEJ4O RU https://pubmed.ncbi.nlm.nih.gov/11787943 DMDTA36 DI DMDTA36 DMDTA36 DN A-252444.0 DMDTA36 MI TTCT6F7 DMDTA36 MN Intercellular adhesion molecule ICAM-1 (ICAM1) DMDTA36 MT DTT DMDTA36 MA Antagonist DMDTA36 RN Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800012566) DMDTA36 RU http://adisinsight.springer.com/drugs/800012566 DMKL482 DI DMKL482 DMKL482 DN A-364 DMKL482 MI TT3C1VN DMKL482 MN Enzyme unspecific (Enz) DMKL482 MT DTT DMKL482 MA Inhibitor DMKL482 RN Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800015550) DMKL482 RU http://adisinsight.springer.com/drugs/800015550 DM4WT7Z DI DM4WT7Z DM4WT7Z DN A-62176 DM4WT7Z MI TT0IHXV DM4WT7Z MN DNA topoisomerase II (TOP2) DM4WT7Z MT DTT DM4WT7Z MA Inhibitor DM4WT7Z RN Design of new topoisomerase II inhibitors based upon a quinobenzoxazine self-assembly model. J Med Chem. 1998 Oct 22;41(22):4273-8. DM4WT7Z RU https://pubmed.ncbi.nlm.nih.gov/9784102 DM4WT7Z DI DM4WT7Z DM4WT7Z DN A-62176 DM4WT7Z MI TT4NVEM DM4WT7Z MN DNA topoisomerase II beta (TOP2B) DM4WT7Z MT DTT DM4WT7Z MA Inhibitor DM4WT7Z RN Design of new topoisomerase II inhibitors based upon a quinobenzoxazine self-assembly model. J Med Chem. 1998 Oct 22;41(22):4273-8. DM4WT7Z RU https://pubmed.ncbi.nlm.nih.gov/9784102 DM1BDHY DI DM1BDHY DM1BDHY DN A-68552 DM1BDHY MI TTKAPQ1 DM1BDHY MN Cholecystokinin receptor (CCKR) DM1BDHY MT DTT DM1BDHY MA Modulator DM1BDHY RN CN patent application no. 102481276, Chemosensory receptor ligand-based therapies. DM1BDHY RU http://www.google.com/patents/CN102481276A?cl=en DMUJ94B DI DMUJ94B DMUJ94B DN A-68930 DMUJ94B MI TTZFYLI DMUJ94B MN Dopamine D1 receptor (D1R) DMUJ94B MT DTT DMUJ94B MA Modulator DMUJ94B RN Comparison of the D1-dopamine agonists SKF-38393 and A-68930 in neonatal 6-hydroxydopamine-lesioned rats: behavioral effects and induction of c-fos-like immunoreactivity. J Pharmacol Exp Ther. 1992 Aug;262(2):855-65. DMUJ94B RU https://pubmed.ncbi.nlm.nih.gov/1354257 DMUJ94B DI DMUJ94B DMUJ94B DN A-68930 DMUJ94B MI TTEX248 DMUJ94B MN Dopamine D2 receptor (D2R) DMUJ94B MT DTT DMUJ94B MA Inhibitor DMUJ94B RN (1R,3S)-1-(aminomethyl)-3,4-dihydro-5,6-dihydroxy-3-phenyl-1H-2-benzopyran: a potent and selective D1 agonist. J Med Chem. 1990 Nov;33(11):2948-50. DMUJ94B RU https://pubmed.ncbi.nlm.nih.gov/1977907 DMPL1OV DI DMPL1OV DMPL1OV DN A-69024 DMPL1OV MI TTZFYLI DMPL1OV MN Dopamine D1 receptor (D1R) DMPL1OV MT DTT DMPL1OV MA Modulator DMPL1OV RN (+)-[76Br]A-69024: a non-benzazepine radioligand for studies of dopamine D1 receptors using PET. Nucl Med Biol. 2002 Apr;29(3):295-302. DMPL1OV RU https://pubmed.ncbi.nlm.nih.gov/11929698 DM9KNFZ DI DM9KNFZ DM9KNFZ DN A-70276 DM9KNFZ MI TTCG0AL DM9KNFZ MN Cholecystokinin receptor type A (CCKAR) DM9KNFZ MT DTT DM9KNFZ MA Modulator DM9KNFZ RN Cholecystokinin antagonists: (R)-tryptophan-based hybrid antagonists of high affinity and selectivity for CCK-A receptors. J Med Chem. 1991 Dec;34(12):3350-9. DM9KNFZ RU https://pubmed.ncbi.nlm.nih.gov/1766000 DM9X24J DI DM9X24J DM9X24J DN A-70826 DM9X24J MI TTN6J5F DM9X24J MN Bacterial DNA gyrase (Bact gyrase) DM9X24J MT DTT DM9X24J MA Modulator DM9X24J RN Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800001978) DM9X24J RU http://adisinsight.springer.com/drugs/800001978 DMKZNTY DI DMKZNTY DMKZNTY DN A-71623 DMKZNTY MI TTCG0AL DMKZNTY MN Cholecystokinin receptor type A (CCKAR) DMKZNTY MT DTT DMKZNTY MA Modulator DMKZNTY RN Characterization of two novel cholecystokinin tetrapeptide (30-33) analogues, A-71623 and A-70874, that exhibit high potency and selectivity for cholecystokinin-A receptors. Mol Pharmacol. 1991 Mar;39(3):346-51. DMKZNTY RU https://pubmed.ncbi.nlm.nih.gov/1706470 DM7FI3S DI DM7FI3S DM7FI3S DN A-72055 DM7FI3S MI TTOXS3C DM7FI3S MN Muscarinic acetylcholine receptor (CHRM) DM7FI3S MT DTT DM7FI3S MA Modulator DM7FI3S RN US patent application no. 2011,0020,423, Methods and compositions for treatment of disorders ameliorated by muscarinic receptor activation. DM7FI3S RU http://www.google.com.ar/patents/US20110020423 DMBEIFL DI DMBEIFL DMBEIFL DN A-74273 DMBEIFL MI TTB2MXP DMBEIFL MN Angiotensinogenase renin (REN) DMBEIFL MT DTT DMBEIFL MA Inhibitor DMBEIFL RN The orally active renin inhibitor A-74273. In vivo and in vitro morpholine ring metabolism in rats, dogs, and humans. Drug Metab Dispos. 1994 Nov-Dec;22(6):880-8. DMBEIFL RU https://pubmed.ncbi.nlm.nih.gov/7895605 DMS3R15 DI DMS3R15 DMS3R15 DN A-74283 DMS3R15 MI TTSQIFT DMS3R15 MN 5-HT 1A receptor (HTR1A) DMS3R15 MT DTT DMS3R15 MA Agonist DMS3R15 RN Cardiovascular activity of A-74283, a 5-hydroxytryptamine 1A agent, in the spontaneously hypertensive rat. Pharmacology. 1998 Jan;56(1):17-29. DMS3R15 RU https://pubmed.ncbi.nlm.nih.gov/9467184 DMNCGOP DI DMNCGOP DMNCGOP DN A-74932 DMNCGOP MI TT0IHXV DMNCGOP MN DNA topoisomerase II (TOP2) DMNCGOP MT DTT DMNCGOP MA Modulator DMNCGOP RN Use of catalytic topoisomerase II inhibitors to probe mechanisms of chemical-induced clastogenicity in Chinese hamster V79 cells. Environ Mol Mutagen. 2000;35(1):13-21. DMNCGOP RU https://www.ncbi.nlm.nih.gov/pubmed/10692223 DMPX37E DI DMPX37E DMPX37E DN A-75169 DMPX37E MI TT2NUT5 DMPX37E MN Adrenergic receptor alpha-2C (ADRA2C) DMPX37E MT DTT DMPX37E MA Modulator DMPX37E RN A-75169 HCI: Pharmacological profile and ocular pharmacology studies of a new alpha-2 antagonist. Drug Development Research Volume 28, Issue 1, pages 56-64, January 1993. DMPX37E RU http://onlinelibrary.wiley.com/doi/10.1002/ddr.430280107/abstract DMC3MH5 DI DMC3MH5 DMC3MH5 DN A-75729 DMC3MH5 MI TTR8XOH DMC3MH5 MN GPCR secretin protein unspecific (GPCRB) DMC3MH5 MT DTT DMC3MH5 MA Modulator DMC3MH5 RN Olfaction. Leffingwell Reports, Vol. 2 (No. 1). May, 2002. DMC3MH5 RU http://www.leffingwell.com/download/Olfaction5.pdf DMRHEWX DI DMRHEWX DMRHEWX DN A-76202M DMRHEWX MI TTXWASR DMRHEWX MN Intestinal maltase-glucoamylase (MGAM) DMRHEWX MT DTT DMRHEWX MA Modulator DMRHEWX RN Synthesis and biological activity of 4',8-dihydroxyisoflavon-7-yl D-hexopyranosides. Carbohydr Res. 2001 Oct 15;335(4):283-9. DMRHEWX RU https://pubmed.ncbi.nlm.nih.gov/11595222 DMTF6D9 DI DMTF6D9 DMTF6D9 DN A-76895 DMTF6D9 MI TTRK8B9 DMTF6D9 MN Sodium channel unspecific (NaC) DMTF6D9 MT DTT DMTF6D9 MA Modulator DMTF6D9 RN CA patent application no. 849505, Sodium channel blockers reduce glucagon secretion. DMTF6D9 RU http://www.google.com/patents/CA2849505A1?cl=en DM4HRXI DI DM4HRXI DM4HRXI DN A-78773 DM4HRXI MI TT2J34L DM4HRXI MN Arachidonate 5-lipoxygenase (5-LOX) DM4HRXI MT DTT DM4HRXI MA Inhibitor DM4HRXI RN (+/-)-trans-2-[3-methoxy-4-(4-chlorophenylthioethoxy)-5-(N-methyl-N- hydroxyureidyl)methylphenyl]-5-(3,4, 5-trimethoxyphenyl)tetrahydrofuran (CMI-3... J Med Chem. 1998 May 21;41(11):1970-9. DM4HRXI RU https://pubmed.ncbi.nlm.nih.gov/9599246 DMT5ZFG DI DMT5ZFG DMT5ZFG DN A-79175 DMT5ZFG MI TT2J34L DMT5ZFG MN Arachidonate 5-lipoxygenase (5-LOX) DMT5ZFG MT DTT DMT5ZFG MA Inhibitor DMT5ZFG RN The role of platelet-activating factor (PAF) and the efficacy of ABT-491, a highly potent and selective PAF antagonist, in experimental allergic rhinitis. J Pharmacol Exp Ther. 1998 Jan;284(1):83-8. DMT5ZFG RU https://pubmed.ncbi.nlm.nih.gov/9435164 DM3IYMF DI DM3IYMF DM3IYMF DN A-79296 DM3IYMF MI TT84ETX DM3IYMF MN Human immunodeficiency virus Reverse transcriptase (HIV RT) DM3IYMF MT DTT DM3IYMF MA Modulator DM3IYMF RN US patent application no. 5,830,759, Unique associated kaposi's sarcoma virus sequences and uses thereof. DM3IYMF RU http://www.google.com/patents/US5830759 DMXWG6Z DI DMXWG6Z DMXWG6Z DN A-798 DMXWG6Z MI TTX4RTB DMXWG6Z MN Melanin-concentrating hormone receptor 1 (MCHR1) DMXWG6Z MT DTT DMXWG6Z MA Antagonist DMXWG6Z RN Disruption of the melanin-concentrating hormone receptor 1 (MCH1R) affects thyroid function. Endocrinology. 2012 Dec;153(12):6145-54. DMXWG6Z RU https://pubmed.ncbi.nlm.nih.gov/23024261 DM89BGE DI DM89BGE DM89BGE DN A-80263 DM89BGE MI TT2J34L DM89BGE MN Arachidonate 5-lipoxygenase (5-LOX) DM89BGE MT DTT DM89BGE MA Inhibitor DM89BGE RN CA patent application no. 445634, Acne treatment comprising lipoxygenase inhibitors. DM89BGE RU http://www.google.com/patents/CA2445634A1?cl=en DMBC3DG DI DMBC3DG DMBC3DG DN A-80426 DMBC3DG MI TTSQIFT DMBC3DG MN 5-HT 1A receptor (HTR1A) DMBC3DG MT DTT DMBC3DG MA Inhibitor DMBC3DG RN Designed multiple ligands. An emerging drug discovery paradigm. J Med Chem. 2005 Oct 20;48(21):6523-43. DMBC3DG RU https://pubmed.ncbi.nlm.nih.gov/16220969 DMBC3DG DI DMBC3DG DMBC3DG DN A-80426 DMBC3DG MI TTJQOD7 DMBC3DG MN 5-HT 2A receptor (HTR2A) DMBC3DG MT DTT DMBC3DG MA Inhibitor DMBC3DG RN Designed multiple ligands. An emerging drug discovery paradigm. J Med Chem. 2005 Oct 20;48(21):6523-43. DMBC3DG RU https://pubmed.ncbi.nlm.nih.gov/16220969 DMBC3DG DI DMBC3DG DMBC3DG DN A-80426 DMBC3DG MI TTWG9A4 DMBC3DG MN Adrenergic receptor alpha-2A (ADRA2A) DMBC3DG MT DTT DMBC3DG MA Inhibitor DMBC3DG RN Discovery of a new series of centrally active tricyclic isoxazoles combining serotonin (5-HT) reuptake inhibition with alpha2-adrenoceptor blocking... J Med Chem. 2005 Mar 24;48(6):2054-71. DMBC3DG RU https://pubmed.ncbi.nlm.nih.gov/15771448 DMBC3DG DI DMBC3DG DMBC3DG DN A-80426 DMBC3DG MI TTWM4TY DMBC3DG MN Adrenergic receptor alpha-2B (ADRA2B) DMBC3DG MT DTT DMBC3DG MA Inhibitor DMBC3DG RN Discovery of a new series of centrally active tricyclic isoxazoles combining serotonin (5-HT) reuptake inhibition with alpha2-adrenoceptor blocking... J Med Chem. 2005 Mar 24;48(6):2054-71. DMBC3DG RU https://pubmed.ncbi.nlm.nih.gov/15771448 DMBC3DG DI DMBC3DG DMBC3DG DN A-80426 DMBC3DG MI TT2NUT5 DMBC3DG MN Adrenergic receptor alpha-2C (ADRA2C) DMBC3DG MT DTT DMBC3DG MA Inhibitor DMBC3DG RN Discovery of a new series of centrally active tricyclic isoxazoles combining serotonin (5-HT) reuptake inhibition with alpha2-adrenoceptor blocking... J Med Chem. 2005 Mar 24;48(6):2054-71. DMBC3DG RU https://pubmed.ncbi.nlm.nih.gov/15771448 DMBC3DG DI DMBC3DG DMBC3DG DN A-80426 DMBC3DG MI TTEX248 DMBC3DG MN Dopamine D2 receptor (D2R) DMBC3DG MT DTT DMBC3DG MA Inhibitor DMBC3DG RN Designed multiple ligands. An emerging drug discovery paradigm. J Med Chem. 2005 Oct 20;48(21):6523-43. DMBC3DG RU https://pubmed.ncbi.nlm.nih.gov/16220969 DMBC3DG DI DMBC3DG DMBC3DG DN A-80426 DMBC3DG MI TTE0A2F DMBC3DG MN Dopamine D4 receptor (D4R) DMBC3DG MT DTT DMBC3DG MA Inhibitor DMBC3DG RN Discovery of a new series of centrally active tricyclic isoxazoles combining serotonin (5-HT) reuptake inhibition with alpha2-adrenoceptor blocking... J Med Chem. 2005 Mar 24;48(6):2054-71. DMBC3DG RU https://pubmed.ncbi.nlm.nih.gov/15771448 DMBC3DG DI DMBC3DG DMBC3DG DN A-80426 DMBC3DG MI TT3ROYC DMBC3DG MN Serotonin transporter (SERT) DMBC3DG MT DTT DMBC3DG MA Inhibitor DMBC3DG RN Structure-activity studies for a novel series of N-(arylethyl)-N-(1,2,3,4-tetrahydronaphthalen-1-ylmethyl)-N-methylamine s possessing dual 5-HT upt... J Med Chem. 1997 Mar 28;40(7):1049-62. DMBC3DG RU https://pubmed.ncbi.nlm.nih.gov/9089327 DMH6LCD DI DMH6LCD DMH6LCD DN A-81282 DMH6LCD MI TTGN1ZA DMH6LCD MN Angiotensin II receptor (AGTR) DMH6LCD MT DTT DMH6LCD MA Modulator DMH6LCD RN Pharmacological characterization of Abbott-81282, a novel, non-peptide angiotensin-II antagonist selective for type-1 receptors. Life Sci. 1993;53(11):929-37. DMH6LCD RU https://pubmed.ncbi.nlm.nih.gov/8366760 DM1GLIN DI DM1GLIN DM1GLIN DN A-81988 DM1GLIN MI TTGN1ZA DM1GLIN MN Angiotensin II receptor (AGTR) DM1GLIN MT DTT DM1GLIN MA Modulator DM1GLIN RN [3H]A-81988, a potent, selective, competitive antagonist radioligand for angiotensin AT1 receptors. Eur J Pharmacol. 1994 Mar 15;267(1):49-54. DM1GLIN RU https://pubmed.ncbi.nlm.nih.gov/8206129 DM1GLIN DI DM1GLIN DM1GLIN DN A-81988 DM1GLIN MI TT8DBY3 DM1GLIN MN Angiotensin II receptor type-1 (AGTR1) DM1GLIN MT DTT DM1GLIN MA Antagonist DM1GLIN RN [3H]A-81988, a potent, selective, competitive antagonist radioligand for angiotensin AT1 receptors. Eur J Pharmacol. 1994 Mar 15;267(1):49-54. DM1GLIN RU https://pubmed.ncbi.nlm.nih.gov/8206129 DMUID46 DI DMUID46 DMUID46 DN A-87049 DMUID46 MI TTFQEO5 DMUID46 MN Squalene synthetase (FDFT1) DMUID46 MT DTT DMUID46 MA Inhibitor DMUID46 RN (1 alpha, 2 beta, 3 beta, 4 alpha)-1,2-bis[N-propyl-N-(4-phenoxybenzyl) amino]carbonyl]cyclobutane-3,4-dicarboxylic acid (A-87049): a novel potent ... J Med Chem. 1997 Jul 4;40(14):2123-5. DMUID46 RU https://pubmed.ncbi.nlm.nih.gov/9216829 DM1KBAY DI DM1KBAY DM1KBAY DN A-93178 DM1KBAY MI TTDMBF5 DM1KBAY MN Arachidonate 5-lipoxygenase activating protein (FLAP) DM1KBAY MT DTT DM1KBAY MA Modulator DM1KBAY RN Characterization of A-93178, an iminoxy-quinoline inhibitor of leukotriene biosynthesis. Adv Exp Med Biol. 1997;433:91-4. DM1KBAY RU https://pubmed.ncbi.nlm.nih.gov/9561111 DMPEB0Z DI DMPEB0Z DMPEB0Z DN AA-861 DMPEB0Z MI TT2J34L DMPEB0Z MN Arachidonate 5-lipoxygenase (5-LOX) DMPEB0Z MT DTT DMPEB0Z MA Inhibitor DMPEB0Z RN Platelets stimulate airway smooth muscle cell proliferation through mechanisms involving 5-lipoxygenase and reactive oxygen species. Platelets. 2008 Nov;19(7):528-36. DMPEB0Z RU https://pubmed.ncbi.nlm.nih.gov/18979365 DMDOQCV DI DMDOQCV DMDOQCV DN ABANOQUIL DMDOQCV MI TTNGILX DMDOQCV MN Adrenergic receptor alpha-1A (ADRA1A) DMDOQCV MT DTT DMDOQCV MA Inhibitor DMDOQCV RN Alpha- and beta-adrenoceptors: from the gene to the clinic. 1. Molecular biology and adrenoceptor subclassification. J Med Chem. 1995 Sep 1;38(18):3415-44. DMDOQCV RU https://pubmed.ncbi.nlm.nih.gov/7658428 DMDOQCV DI DMDOQCV DMDOQCV DN ABANOQUIL DMDOQCV MI TTBRKXS DMDOQCV MN Adrenergic receptor alpha-1B (ADRA1B) DMDOQCV MT DTT DMDOQCV MA Inhibitor DMDOQCV RN Alpha- and beta-adrenoceptors: from the gene to the clinic. 1. Molecular biology and adrenoceptor subclassification. J Med Chem. 1995 Sep 1;38(18):3415-44. DMDOQCV RU https://pubmed.ncbi.nlm.nih.gov/7658428 DMDOQCV DI DMDOQCV DMDOQCV DN ABANOQUIL DMDOQCV MI TT34BHT DMDOQCV MN Adrenergic receptor alpha-1D (ADRA1D) DMDOQCV MT DTT DMDOQCV MA Inhibitor DMDOQCV RN Alpha- and beta-adrenoceptors: from the gene to the clinic. 1. Molecular biology and adrenoceptor subclassification. J Med Chem. 1995 Sep 1;38(18):3415-44. DMDOQCV RU https://pubmed.ncbi.nlm.nih.gov/7658428 DMALPDW DI DMALPDW DMALPDW DN ABS-205 DMALPDW MI TTD26RC DMALPDW MN Cell adhesion molecule (CADM) DMALPDW MT DTT DMALPDW MA Modulator DMALPDW RN Drug Discovery and Development for Alzheimer's Disease, 2000. Page(21). DMALPDW RU https://books.google.com.hk/books?id=mB0SXrpofmwC&pg=PA184&lpg=PA184&dq=%22ABS-205%22++Cell+adhesion&source=bl&ots=UtcoGEnNKZ&sig=1dVQ1oxHOCcy90TN5liCl__WXno&hl=zh-CN&sa=X&ved=0CCsQ6AEwAmoVChMIhIOO3Me_yAIVAsKOCh2rAgWU#v=onepage&q=%22ABS-205%22%20%20Cell%20adhesion&f=false DMZ52P6 DI DMZ52P6 DMZ52P6 DN ABS-212 DMZ52P6 MI TTTUMEP DMZ52P6 MN Neurotensin receptor type 1 (NTSR1) DMZ52P6 MT DTT DMZ52P6 MA Agonist DMZ52P6 RN Identification and functional characterization of a stable, centrally active derivative of the neurotensin (8-13) fragment as a potential first-in-class analgesic. J Med Chem. 2010 Jun 24;53(12):4623-32. DMZ52P6 RU https://pubmed.ncbi.nlm.nih.gov/20481538 DMCW5DJ DI DMCW5DJ DMCW5DJ DN ABS-301 DMCW5DJ MI TT1RS9F DMCW5DJ MN Acetylcholinesterase (AChE) DMCW5DJ MT DTT DMCW5DJ MA Modulator DMCW5DJ RN Novel tacrine analogues for potential use against Alzheimer's disease: potent and selective acetylcholinesterase inhibitors and 5-HT uptake inhibitors. J Med Chem. 1997 Oct 24;40(22):3516-23. DMCW5DJ RU https://pubmed.ncbi.nlm.nih.gov/9357518 DMPFLS5 DI DMPFLS5 DMPFLS5 DN ABT-100 DMPFLS5 MI TT7WZIJ DMPFLS5 MN CAAX farnesyltransferase beta (FNTB) DMPFLS5 MT DTT DMPFLS5 MA Inhibitor DMPFLS5 RN Potent farnesyltransferase inhibitor ABT-100 abrogates acute allograft rejection. J Heart Lung Transplant. 2005 Sep;24(9):1403-9. DMPFLS5 RU https://pubmed.ncbi.nlm.nih.gov/16143263 DMYJMV9 DI DMYJMV9 DMYJMV9 DN ABT-702 DMYJMV9 MI TTL732K DMYJMV9 MN Adenosine kinase (ADK) DMYJMV9 MT DTT DMYJMV9 MA Inhibitor DMYJMV9 RN ABT-702, an adenosine kinase inhibitor, attenuates inflammation in diabetic retinopathy. Life Sci. 2013 Jul 30;93(2-3):78-88. DMYJMV9 RU https://pubmed.ncbi.nlm.nih.gov/23770229 DML0DBV DI DML0DBV DML0DBV DN ABT-737 DML0DBV MI TTJGNVC DML0DBV MN Apoptosis regulator Bcl-2 (BCL-2) DML0DBV MT DTT DML0DBV MA Inhibitor DML0DBV RN Studies leading to potent, dual inhibitors of Bcl-2 and Bcl-xL. J Med Chem. 2007 Feb 22;50(4):641-62. DML0DBV RU https://pubmed.ncbi.nlm.nih.gov/17256834 DML0DBV DI DML0DBV DML0DBV DN ABT-737 DML0DBV MI DTUGYRD DML0DBV MN P-glycoprotein 1 (ABCB1) DML0DBV MT DTP DML0DBV MA Substrate DML0DBV RN The B-cell lymphoma 2 (BCL2)-inhibitors, ABT-737 and ABT-263, are substrates for P-glycoprotein. Biochem Biophys Res Commun. 2011 May 6;408(2):344-9. DML0DBV RU https://doi.org/10.1016/j.bbrc.2011.04.043 DM4UN9A DI DM4UN9A DM4UN9A DN ABT-839 DM4UN9A MI TT7WZIJ DM4UN9A MN CAAX farnesyltransferase beta (FNTB) DM4UN9A MT DTT DM4UN9A MA Inhibitor DM4UN9A RN Design and synthesis of o-trifluoromethylbiphenyl substituted 2-amino-nicotinonitriles as inhibitors of farnesyltransferase. Bioorg Med Chem Lett. 2005 Jan 3;15(1):153-8. DM4UN9A RU https://pubmed.ncbi.nlm.nih.gov/15582430 DM4UN9A DI DM4UN9A DM4UN9A DN ABT-839 DM4UN9A MI TTXQKM3 DM4UN9A MN Farnesyl protein transferase (Ftase) DM4UN9A MT DTT DM4UN9A MA Inhibitor DM4UN9A RN Aryl tetrahydropyridine inhibitors of farnesyltransferase: glycine, phenylalanine and histidine derivatives. Bioorg Med Chem Lett. 2003 Apr 7;13(7):1359-62. DM4UN9A RU https://pubmed.ncbi.nlm.nih.gov/12657282 DMDPUK6 DI DMDPUK6 DMDPUK6 DN ABX-PTH DMDPUK6 MI TT6F7GZ DMDPUK6 MN Parathyroid hormone (PTH) DMDPUK6 MT DTT DMDPUK6 RN Focus on parathyroid carcinoma. International Journal of Surgery Volume 9, Issue 1, 2011, Pages 13-19. DMDPUK6 RU http://www.sciencedirect.com/science/article/pii/S1743919110004437 DM5IDAQ DI DM5IDAQ DM5IDAQ DN AC-187 DM5IDAQ MI TTAT87F DM5IDAQ MN Amylin receptor (IAPPR) DM5IDAQ MT DTT DM5IDAQ MA Modulator DM5IDAQ RN Antagonist of the amylin receptor blocks beta-amyloid toxicity in rat cholinergic basal forebrain neurons. J Neurosci. 2004 Jun 16;24(24):5579-84. DM5IDAQ RU https://pubmed.ncbi.nlm.nih.gov/15201330 DMA93D8 DI DMA93D8 DMA93D8 DN AC-260584 DMA93D8 MI TTZ9SOR DMA93D8 MN Muscarinic acetylcholine receptor M1 (CHRM1) DMA93D8 MT DTT DMA93D8 MA Agonist DMA93D8 RN Pharmacological comparison of muscarinic ligands: historical versus more recent muscarinic M1-preferring receptor agonists. Eur J Pharmacol. 2009 Mar 1;605(1-3):53-6. DMA93D8 RU https://pubmed.ncbi.nlm.nih.gov/19168056 DMBY7AZ DI DMBY7AZ DMBY7AZ DN ACEA-1011 DMBY7AZ MI TT9IK2Z DMBY7AZ MN N-methyl-D-aspartate receptor (NMDAR) DMBY7AZ MT DTT DMBY7AZ MA Modulator DMBY7AZ RN NMDA receptor antagonists, MK-801 and ACEA-1011, prevent the development of tonic pain following subcutaneous formalin. Brain Res. 1993 Jul 2;615(2):331-4. DMBY7AZ RU https://pubmed.ncbi.nlm.nih.gov/8364741 DMCWNVB DI DMCWNVB DMCWNVB DN ACEA-1031 DMCWNVB MI TT9IK2Z DMCWNVB MN N-methyl-D-aspartate receptor (NMDAR) DMCWNVB MT DTT DMCWNVB MA Modulator DMCWNVB RN In vitro pharmacology of ACEA-1021 and ACEA-1031: systemically active quinoxalinediones with high affinity and selectivity for N-methyl-D-aspartate receptor glycine sites. Mol Pharmacol. 1995 Mar;47(3):568-81. DMCWNVB RU https://pubmed.ncbi.nlm.nih.gov/7700254 DMEH9OY DI DMEH9OY DMEH9OY DN ACEA-1328 DMEH9OY MI TT9IK2Z DMEH9OY MN N-methyl-D-aspartate receptor (NMDAR) DMEH9OY MT DTT DMEH9OY MA Antagonist DMEH9OY RN Emerging analgesics in cancer pain management. Expert Opin Emerg Drugs. 2005 Feb;10(1):151-71. DMEH9OY RU https://pubmed.ncbi.nlm.nih.gov/15757410 DMRHSG4 DI DMRHSG4 DMRHSG4 DN ACEA-1416 DMRHSG4 MI TT9IK2Z DMRHSG4 MN N-methyl-D-aspartate receptor (NMDAR) DMRHSG4 MT DTT DMRHSG4 MA Modulator DMRHSG4 RN Tolerance develops to the antinociceptive and motor impairing effects of ACEA-1416, a NMDA receptor antagonist, in the formalin and rotarod test in mice. Pharmacol Res. 1998 Apr;37(4):295-302. DMRHSG4 RU https://pubmed.ncbi.nlm.nih.gov/9634646 DMXLB02 DI DMXLB02 DMXLB02 DN ACEA-2085 DMXLB02 MI TTAN6JD DMXLB02 MN Glutamate receptor AMPA (GRIA) DMXLB02 MT DTT DMXLB02 MA Antagonist DMXLB02 RN Interaction among NMDA receptor-, NMDA glycine site- and AMPA receptor antagonists in spinally mediated analgesia. Can J Anaesth. 2000 Jul;47(7):693-8. DMXLB02 RU https://pubmed.ncbi.nlm.nih.gov/10930211 DM0YHKB DI DM0YHKB DM0YHKB DN Acteoside DM0YHKB MI TTFJ8Q1 DM0YHKB MN Protein kinase C alpha (PRKCA) DM0YHKB MT DTT DM0YHKB MA Inhibitor DM0YHKB RN Phenylethanoid glycosides from Digitalis purpurea and Penstemon linarioides with PKCalpha-inhibitory activity. J Nat Prod. 1998 Nov;61(11):1410-2. DM0YHKB RU https://pubmed.ncbi.nlm.nih.gov/9834166 DMT4P89 DI DMT4P89 DMT4P89 DN Actinonin DMT4P89 MI TTICO5G DMT4P89 MN Staphylococcus Peptide deformylase (Stap-coc def) DMT4P89 MT DTT DMT4P89 MA Inhibitor DMT4P89 RN Actinonin, a naturally occurring antibacterial agent, is a potent deformylase inhibitor. Biochemistry. 2000 Feb 15;39(6):1256-62. DMT4P89 RU https://pubmed.ncbi.nlm.nih.gov/10684604 DMJFY2I DI DMJFY2I DMJFY2I DN AD 198 DMJFY2I MI TT9WJ8U DMJFY2I MN Protein kinase C delta (PRKCD) DMJFY2I MT DTT DMJFY2I MA Activator DMJFY2I RN Novel extranuclear-targeted anthracyclines override the antiapoptotic functions of Bcl-2 and target protein kinase C pathways to induce apoptosis. Mol Cancer Ther. 2002 May;1(7):469-81. DMJFY2I RU https://pubmed.ncbi.nlm.nih.gov/12479265 DM1SLJ9 DI DM1SLJ9 DM1SLJ9 DN AD-5075 DM1SLJ9 MI TTZMAO3 DM1SLJ9 MN Peroxisome proliferator-activated receptor gamma (PPAR-gamma) DM1SLJ9 MT DTT DM1SLJ9 MA Modulator DM1SLJ9 RN Thiazolidinediones produce a conformational change in peroxisomal proliferator-activated receptor-gamma: binding and activation correlate with antidiabetic actions in db/db mice. Endocrinology. 1996 Oct;137(10):4189-95. DM1SLJ9 RU https://pubmed.ncbi.nlm.nih.gov/8828476 DM1SLJ9 DI DM1SLJ9 DM1SLJ9 DN AD-5075 DM1SLJ9 MI TTT2SVW DM1SLJ9 MN PPAR-gamma messenger RNA (PPARG mRNA) DM1SLJ9 MT DTT DM1SLJ9 MA Agonist DM1SLJ9 RN Thiazolidinediones produce a conformational change in peroxisomal proliferator-activated receptor-gamma: binding and activation correlate with antidiabetic actions in db/db mice. Endocrinology. 1996 Oct;137(10):4189-95. DM1SLJ9 RU https://pubmed.ncbi.nlm.nih.gov/8828476 DMQNFZE DI DMQNFZE DMQNFZE DN Ad5-AC6 DMQNFZE MI TT2QM9D DMQNFZE MN Adenylate cyclase (ADCY) DMQNFZE MT DTT DMQNFZE MA Modulator DMQNFZE RN Unanticipated Signaling Events Associated with Cardiac Adenylyl Cyclase Gene Transfer. J Mol Cell Cardiol. 2011 May; 50(5): 751-758. DMQNFZE RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3095111/ DM61AV4 DI DM61AV4 DM61AV4 DN ADX415 DM61AV4 MI TTQ8AFT DM61AV4 MN Adrenergic receptor Alpha-2 (ADRA2) DM61AV4 MT DTT DM61AV4 MA Antagonist DM61AV4 RN Clinical pipeline report, company report or official report of Shionogi (2011). DM61AV4 RU http://www.shionogi.co.jp/index_e.html DM625LN DI DM625LN DM625LN DN AG-041R DM625LN MI TTVFO0U DM625LN MN Gastrin/cholecystokinin type B receptor (CCKBR) DM625LN MT DTT DM625LN MA Modulator DM625LN RN AG-041R, a gastrin/CCK-B antagonist, stimulates chondrocyte proliferation and metabolism in vitro. Biochem Biophys Res Commun. 2001 May 25;283(5):1118-23. DM625LN RU https://pubmed.ncbi.nlm.nih.gov/11355888 DMRI7YB DI DMRI7YB DMRI7YB DN AG-1284 DMRI7YB MI TT5FNQT DMRI7YB MN Human immunodeficiency virus Protease (HIV PR) DMRI7YB MT DTT DMRI7YB MA Modulator DMRI7YB RN Exploring the energy landscapes of molecular recognition by a genetic algorithm: analysis of the requirements for robust docking of HIV-1 protease and FKBP-12 complexes. Proteins. 1996 Jul;25(3):342-53. DMRI7YB RU https://pubmed.ncbi.nlm.nih.gov/8844869 DMT10C2 DI DMT10C2 DMT10C2 DN AG1295 DMT10C2 MI TTGJCWZ DMT10C2 MN Fms-like tyrosine kinase 3 (FLT-3) DMT10C2 MT DTT DMT10C2 MA Inhibitor DMT10C2 RN Inhibition of FLT3 and PDGFR tyrosine kinase activity by bis(benzo[b]furan-2-yl)methanones. Bioorg Med Chem. 2007 Mar 1;15(5):2187-97. DMT10C2 RU https://pubmed.ncbi.nlm.nih.gov/17210255 DMT10C2 DI DMT10C2 DMT10C2 DN AG1295 DMT10C2 MI TT8FYO9 DMT10C2 MN Platelet-derived growth factor receptor alpha (PDGFRA) DMT10C2 MT DTT DMT10C2 MA Inhibitor DMT10C2 RN Novel bis(1H-indol-2-yl)methanones as potent inhibitors of FLT3 and platelet-derived growth factor receptor tyrosine kinase. J Med Chem. 2006 Jun 1;49(11):3101-15. DMT10C2 RU https://pubmed.ncbi.nlm.nih.gov/16722630 DMT10C2 DI DMT10C2 DMT10C2 DN AG1295 DMT10C2 MI TTI7421 DMT10C2 MN Platelet-derived growth factor receptor beta (PDGFRB) DMT10C2 MT DTT DMT10C2 MA Inhibitor DMT10C2 RN Inhibition of FLT3 and PDGFR tyrosine kinase activity by bis(benzo[b]furan-2-yl)methanones. Bioorg Med Chem. 2007 Mar 1;15(5):2187-97. DMT10C2 RU https://pubmed.ncbi.nlm.nih.gov/17210255 DMT10C2 DI DMT10C2 DMT10C2 DN AG1295 DMT10C2 MI TTUTJGQ DMT10C2 MN Vascular endothelial growth factor receptor 2 (KDR) DMT10C2 MT DTT DMT10C2 MA Inhibitor DMT10C2 RN Design, synthesis, and X-ray crystal structures of 2,4-diaminofuro[2,3-d]pyrimidines as multireceptor tyrosine kinase and dihydrofolate reductase i... Bioorg Med Chem. 2009 Oct 15;17(20):7324-36. DMT10C2 RU https://pubmed.ncbi.nlm.nih.gov/19748785 DMALV1W DI DMALV1W DMALV1W DN AG-1350 DMALV1W MI TT5FNQT DMALV1W MN Human immunodeficiency virus Protease (HIV PR) DMALV1W MT DTT DMALV1W MA Inhibitor DMALV1W RN Ly316340: A potent HIV-1 protease inhibitor containing a high affinity octahydrothienopyridine hydroxyethylamine isostere. Bioorganic & Medicinal Chemistry Letters Volume 5, Issue 23, 7 December 1995, Pages 2885-2890. DMALV1W RU http://www.sciencedirect.com/science/article/pii/0960894X9500506O DMS7UPZ DI DMS7UPZ DMS7UPZ DN AG-2024 DMS7UPZ MI TT1GHVO DMS7UPZ MN Matrix metalloproteinase (MMP) DMS7UPZ MT DTT DMS7UPZ MA Modulator DMS7UPZ RN US patent application no. 6,858,598, Method of using a matrix metalloproteinase inhibitor and one or more antineoplastic agents as a combination therapy in the treatment of neoplasia. DMS7UPZ RU https://www.google.com.ar/patents/US6858598 DMF2ME4 DI DMF2ME4 DMF2ME4 DN AG-3296 DMF2ME4 MI TT1GHVO DMF2ME4 MN Matrix metalloproteinase (MMP) DMF2ME4 MT DTT DMF2ME4 MA Modulator DMF2ME4 RN US patent application no. 6,858,598, Method of using a matrix metalloproteinase inhibitor and one or more antineoplastic agents as a combination therapy in the treatment of neoplasia. DMF2ME4 RU https://www.google.com.ar/patents/US6858598 DM3WKO5 DI DM3WKO5 DM3WKO5 DN AG490 DM3WKO5 MI TTRMX3V DM3WKO5 MN Janus kinase 2 (JAK-2) DM3WKO5 MT DTT DM3WKO5 MA Inhibitor DM3WKO5 RN Jak2 tyrosine kinase mediates oxidative stress-induced apoptosis in vascular smooth muscle cells. J Biol Chem. 2004 Aug 13;279(33):34547-52. DM3WKO5 RU https://pubmed.ncbi.nlm.nih.gov/15159394 DM3WKO5 DI DM3WKO5 DM3WKO5 DN AG490 DM3WKO5 MI TTT7PJU DM3WKO5 MN Janus kinase 3 (JAK-3) DM3WKO5 MT DTT DM3WKO5 MA Inhibitor DM3WKO5 RN Immunotherapy for De Novo renal transplantation: what's in the pipeline Drugs. 2006;66(13):1665-84. DM3WKO5 RU https://pubmed.ncbi.nlm.nih.gov/16978033 DMVS6BN DI DMVS6BN DMVS6BN DN AGN-193080 DMVS6BN MI TTNGILX DMVS6BN MN Adrenergic receptor alpha-1A (ADRA1A) DMVS6BN MT DTT DMVS6BN MA Inhibitor DMVS6BN RN Analogs of UK 14,304: Structural features responsible for alpha2 adrenoceptor activity, Bioorg. Med. Chem. Lett. 5(15):1745-1750 (1995). DMVS6BN RU http://www.sciencedirect.com/science/article/pii/0960894X95002955 DMVS6BN DI DMVS6BN DMVS6BN DN AGN-193080 DMVS6BN MI TTBRKXS DMVS6BN MN Adrenergic receptor alpha-1B (ADRA1B) DMVS6BN MT DTT DMVS6BN MA Inhibitor DMVS6BN RN Analogs of UK 14,304: Structural features responsible for alpha2 adrenoceptor activity, Bioorg. Med. Chem. Lett. 5(15):1745-1750 (1995). DMVS6BN RU http://www.sciencedirect.com/science/article/pii/0960894X95002955 DMVS6BN DI DMVS6BN DMVS6BN DN AGN-193080 DMVS6BN MI TT34BHT DMVS6BN MN Adrenergic receptor alpha-1D (ADRA1D) DMVS6BN MT DTT DMVS6BN MA Inhibitor DMVS6BN RN Analogs of UK 14,304: Structural features responsible for alpha2 adrenoceptor activity, Bioorg. Med. Chem. Lett. 5(15):1745-1750 (1995). DMVS6BN RU http://www.sciencedirect.com/science/article/pii/0960894X95002955 DMXY5AV DI DMXY5AV DMXY5AV DN AH-9700 DMXY5AV MI TT5TPI6 DMXY5AV MN Opioid receptor sigma 1 (OPRS1) DMXY5AV MT DTT DMXY5AV MA Modulator DMXY5AV RN Pharmacological actions of AH-9700 on micturition reflex in anesthetized rats. Eur J Pharmacol. 2001 Jan 26;412(2):171-9. DMXY5AV RU https://pubmed.ncbi.nlm.nih.gov/11165228 DMJZ48W DI DMJZ48W DMJZ48W DN AHR-16303B DMJZ48W MI TTYSN63 DMJZ48W MN 5-HT 2 receptor (5HT2R) DMJZ48W MT DTT DMJZ48W MA Modulator DMJZ48W RN AHR-16303B, a novel antagonist of 5-HT2 receptors and voltage-sensitive calcium channels. J Cardiovasc Pharmacol. 1991 Jan;17(1):41-53. DMJZ48W RU https://pubmed.ncbi.nlm.nih.gov/1708055 DMJZ48W DI DMJZ48W DMJZ48W DN AHR-16303B DMJZ48W MI TT5HONZ DMJZ48W MN Calcium channel unspecific (CaC) DMJZ48W MT DTT DMJZ48W MA Modulator DMJZ48W RN AHR-16303B, a novel antagonist of 5-HT2 receptors and voltage-sensitive calcium channels. J Cardiovasc Pharmacol. 1991 Jan;17(1):41-53. DMJZ48W RU https://pubmed.ncbi.nlm.nih.gov/1708055 DMJ6BEO DI DMJ6BEO DMJ6BEO DN AHR-16462B DMJ6BEO MI TT5HONZ DMJ6BEO MN Calcium channel unspecific (CaC) DMJ6BEO MT DTT DMJ6BEO MA Modulator DMJ6BEO RN A pharmacological and biochemical examination of AHR-16462B, a novel calcium antagonist coronary vasodilator/antihypertensive. Drug Development Research. 01/1991; 22(3):259-271. DMJ6BEO RU http://www.researchgate.net/publication/240125183_A_pharmacological_and_biochemical_examination_of_AHR-16462B_a_novel_calcium_antagonist_coronary_vasodilatorantihypertensive DMOJTZV DI DMOJTZV DMOJTZV DN AJ-3941 DMOJTZV MI TT5HONZ DMOJTZV MN Calcium channel unspecific (CaC) DMOJTZV MT DTT DMOJTZV MA Modulator DMOJTZV RN Prevention by the new Ca2+ channel antagonist, AJ-3941, of loss of endothelium-dependent relaxation after subarachnoid hemorrhage in rats. Eur J Pharmacol. 1996 Nov 21;315(3):297-303. DMOJTZV RU https://pubmed.ncbi.nlm.nih.gov/8982668 DM51NI0 DI DM51NI0 DM51NI0 DN AK-295 DM51NI0 MI TTG5QB7 DM51NI0 MN Calpain-2 (CAPN2) DM51NI0 MT DTT DM51NI0 MA Inhibitor DM51NI0 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2336). DM51NI0 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2336 DMMTZXV DI DMMTZXV DMMTZXV DN AKP-320 DMMTZXV MI TTZMAO3 DMMTZXV MN Peroxisome proliferator-activated receptor gamma (PPAR-gamma) DMMTZXV MT DTT DMMTZXV MA Modulator DMMTZXV RN Chronic glucose-lowering effects of rosiglitazone and bis(ethylmaltolato) oxovanadium(IV) in ZDF rats. Canadian Journal of Physiology and Pharmacology. 12/2003; 81(11):1049-55. DMMTZXV RU http://www.researchgate.net/publication/8922382_Chronic_glucose-lowering_effects_of_rosiglitazone_and_bis(ethylmaltolato)_oxovanadium(IV)_in_ZDF_rats DMRYJ40 DI DMRYJ40 DMRYJ40 DN AL-0671 DMRYJ40 MI TT1VOHK DMRYJ40 MN Potassium channel unspecific (KC) DMRYJ40 MT DTT DMRYJ40 MA Opener DMRYJ40 RN A possible mechanism of action of a new potassium channel opener, AL0671, on lipid metabolism in obese Zucker rats. J Pharmacol Exp Ther. 1994 Dec;271(3):1666-71. DMRYJ40 RU https://pubmed.ncbi.nlm.nih.gov/7996482 DMWNMYS DI DMWNMYS DMWNMYS DN ALB-127158(a) DMWNMYS MI TTX4RTB DMWNMYS MN Melanin-concentrating hormone receptor 1 (MCHR1) DMWNMYS MT DTT DMWNMYS MA Antagonist DMWNMYS RN Clinical pipeline report, company report or official report of Albany Molecular Research (2011). DMWNMYS RU http://www.amriglobal.com/ DMXK4CI DI DMXK4CI DMXK4CI DN Albupoietin DMXK4CI MI TTAUX24 DMXK4CI MN Erythropoietin Receptor (EPOR) DMXK4CI MT DTT DMXK4CI MA Modulator DMXK4CI RN Clinical pipeline report, company report or official report of cogenesys. DMXK4CI RU http://cogenesys.com/Collaboration.asp DMQALR5 DI DMQALR5 DMQALR5 DN Almorexant DMQALR5 MI TT60Q8D DMQALR5 MN Orexin receptor type 1 (HCRTR1) DMQALR5 MT DTT DMQALR5 MA Antagonist DMQALR5 RN Biochemical and electrophysiological characterization of almorexant, a dual orexin 1 receptor (OX1)/orexin 2 receptor (OX2) antagonist: comparison ... Mol Pharmacol. 2009 Sep;76(3):618-31. DMQALR5 RU https://pubmed.ncbi.nlm.nih.gov/19542319 DMT584A DI DMT584A DMT584A DN ALN-VEG01 DMT584A MI TT3LJ9K DMT584A MN VEGF messenger RNA (VEGF mRNA) DMT584A MT DTT DMT584A RN Clinical pipeline report, company report or official report of Alnylam Pharmaceuticals. DMT584A RU http://investors.alnylam.com/releasedetail.cfm?ReleaseID=446269 DM592WE DI DM592WE DM592WE DN ALP-242 DM592WE MI TTZBFA0 DM592WE MN Protease unspecific (PRO) DM592WE MT DTT DM592WE MA Modulator DM592WE RN Oxidation resistant muteins of antileukoproteinase as potential therapeutic agents. Agents Actions Suppl. 1993;42:111-21. DM592WE RU https://pubmed.ncbi.nlm.nih.gov/8356918 DMGBT9Z DI DMGBT9Z DMGBT9Z DN ALS-769 DMGBT9Z MI TTZY5KP DMGBT9Z MN Caspase (CASP) DMGBT9Z MT DTT DMGBT9Z MA Inducer DMGBT9Z RN Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800025089) DMGBT9Z RU http://adisinsight.springer.com/drugs/800025089 DMLN0Y5 DI DMLN0Y5 DMLN0Y5 DN Alvameline DMLN0Y5 MI TTZ9SOR DMLN0Y5 MN Muscarinic acetylcholine receptor M1 (CHRM1) DMLN0Y5 MT DTT DMLN0Y5 MA Modulator DMLN0Y5 RN In vivo muscarinic cholinergic mediated effects of Lu 25-109, a M1 agonist and M2/M3 antagonist in vitro. Psychopharmacology (Berl). 1998 Jun;137(3):233-40. DMLN0Y5 RU https://pubmed.ncbi.nlm.nih.gov/9683000 DMLN0Y5 DI DMLN0Y5 DMLN0Y5 DN Alvameline DMLN0Y5 MI TTYEG6Q DMLN0Y5 MN Muscarinic acetylcholine receptor M2 (CHRM2) DMLN0Y5 MT DTT DMLN0Y5 MA Modulator DMLN0Y5 RN In vivo muscarinic cholinergic mediated effects of Lu 25-109, a M1 agonist and M2/M3 antagonist in vitro. Psychopharmacology (Berl). 1998 Jun;137(3):233-40. DMLN0Y5 RU https://pubmed.ncbi.nlm.nih.gov/9683000 DMLN0Y5 DI DMLN0Y5 DMLN0Y5 DN Alvameline DMLN0Y5 MI TTQ13Z5 DMLN0Y5 MN Muscarinic acetylcholine receptor M3 (CHRM3) DMLN0Y5 MT DTT DMLN0Y5 MA Modulator DMLN0Y5 RN In vivo muscarinic cholinergic mediated effects of Lu 25-109, a M1 agonist and M2/M3 antagonist in vitro. Psychopharmacology (Berl). 1998 Jun;137(3):233-40. DMLN0Y5 RU https://pubmed.ncbi.nlm.nih.gov/9683000 DMOIWFM DI DMOIWFM DMOIWFM DN AM-577 DMOIWFM MI TTMSFAW DMOIWFM MN Cannabinoid receptor 2 (CB2) DMOIWFM MT DTT DMOIWFM MA Agonist DMOIWFM RN Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800018288) DMOIWFM RU http://adisinsight.springer.com/drugs/800018288 DMGBT63 DI DMGBT63 DMGBT63 DN AM-66 DMGBT63 MI TTRK8B9 DMGBT63 MN Sodium channel unspecific (NaC) DMGBT63 MT DTT DMGBT63 MA Blocker DMGBT63 RN CA patent application no. 849505, Sodium channel blockers reduce glucagon secretion. DMGBT63 RU http://www.google.com/patents/CA2849505A1?cl=en DMMZNSC DI DMMZNSC DMMZNSC DN AM-92016 DMMZNSC MI TTLD29N DMMZNSC MN Glutamate receptor ionotropic NMDA 1 (NMDAR1) DMMZNSC MT DTT DMMZNSC MA Inhibitor DMMZNSC RN Enantiomeric propanolamines as selective N-methyl-D-aspartate 2B receptor antagonists. J Med Chem. 2008 Sep 25;51(18):5506-21. DMMZNSC RU https://pubmed.ncbi.nlm.nih.gov/18800760 DMYIPLH DI DMYIPLH DMYIPLH DN AMG-548 DMYIPLH MI TTWELHI DMYIPLH MN Stress-activated protein kinase (p38) DMYIPLH MT DTT DMYIPLH MA Inhibitor DMYIPLH RN p38 MAP kinase inhibitors: many are made, but few are chosen. Curr Opin Drug Discov Devel. 2005 Jul;8(4):421-30. DMYIPLH RU https://pubmed.ncbi.nlm.nih.gov/16022178 DMXRQS6 DI DMXRQS6 DMXRQS6 DN AMG-8562 DMXRQS6 MI TTMI6F5 DMXRQS6 MN Transient receptor potential cation channel V1 (TRPV1) DMXRQS6 MT DTT DMXRQS6 MA Blocker DMXRQS6 RN Analgesic potential of TRPV1 antagonists. Biochem Pharmacol. 2009 Aug 1;78(3):211-6. DMXRQS6 RU https://pubmed.ncbi.nlm.nih.gov/19481638 DM3D0WA DI DM3D0WA DM3D0WA DN Amidox DM3D0WA MI TTX09M4 DM3D0WA MN Ribonucleotide reductase (RIR) DM3D0WA MT DTT DM3D0WA MA Inhibitor DM3D0WA RN Metabolism of the new ribonucleotide reductase inhibitor amidox in the isolated perfused rat liver. Anticancer Res. 2000 Sep- Oct;20(5B):3521-6. DM3D0WA RU https://pubmed.ncbi.nlm.nih.gov/11131656 DM64YJW DI DM64YJW DM64YJW DN Amitivir DM64YJW MI TTIU7X1 DM64YJW MN Herpes simplex virus DNA polymerase UL30 (HSV UL30) DM64YJW MT DTT DM64YJW MA Modulator DM64YJW RN Approaches and strategies for the treatment of influenza virus infections. Antivir Chem Chemother. 1999 Jul;10(4):155-85. DM64YJW RU https://pubmed.ncbi.nlm.nih.gov/10480736 DMDAMBW DI DMDAMBW DMDAMBW DN AMPEROZIDE DMDAMBW MI TTJQOD7 DMDAMBW MN 5-HT 2A receptor (HTR2A) DMDAMBW MT DTT DMDAMBW MA Modulator DMDAMBW RN Action of the 5-HT2A antagonist amperozide on alcohol-induced poikilothermia in rats. Pharmacol Biochem Behav. 1998 Jan;59(1):91-5. DMDAMBW RU https://www.ncbi.nlm.nih.gov/pubmed/9443541 DMW5RNZ DI DMW5RNZ DMW5RNZ DN AMR-103 DMW5RNZ MI TTEX248 DMW5RNZ MN Dopamine D2 receptor (D2R) DMW5RNZ MT DTT DMW5RNZ MA Agonist DMW5RNZ RN ACP-103, a 5-HT2A/2C inverse agonist, potentiates haloperidol-induced dopamine release in rat medial prefrontal cortex and nucleus accumbens. Psychopharmacology (Berl). 2005 Dec;183(2):144-53. DMW5RNZ RU https://pubmed.ncbi.nlm.nih.gov/16220333 DMD82LM DI DMD82LM DMD82LM DN AMT-030 DMD82LM MI TTF5NVW DMD82LM MN Alanine glyoxylate aminotransferase (AGXT) DMD82LM MT DTT DMD82LM MA Modulator DMD82LM RN Adenovirus-associated virus vector-mediated gene transfer in hemophilia B. N Engl J Med. 2011 Dec 22;365(25):2357-65. DMD82LM RU https://pubmed.ncbi.nlm.nih.gov/22149959 DMMKOCL DI DMMKOCL DMMKOCL DN AMT-050 DMMKOCL MI TT7GN3U DMMKOCL MN Apolipoprotein A-I (APOA1) DMMKOCL MT DTT DMMKOCL MA Modulator DMMKOCL RN Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800026835) DMMKOCL RU http://adisinsight.springer.com/drugs/800026835 DM50HB8 DI DM50HB8 DM50HB8 DN AN-10 DM50HB8 MI TTQO71U DM50HB8 MN Hemoglobin (HB) DM50HB8 MT DTT DM50HB8 MA Modulator DM50HB8 RN Genes for Development, Cell Growth and Infectious Diseases, Gabriel Gachelin, 1995. Page(215). DM50HB8 RU https://books.google.com.hk/books?id=pFFFUsab0P4C&pg=PA215&lpg=PA215&dq=%22AN-10%22+Hemoglobin&source=bl&ots=qL5psDKJAZ&sig=fpeRIeD9GtukNkelArzs80kTSAo&hl=zh-CN&sa=X&ved=0CBoQ6AEwAGoVChMI-cbDu7DDyAIVzQmOCh3V2QwO#v=onepage&q=%22AN-10%22%20Hemoglobin&f=false DMMLDG8 DI DMMLDG8 DMMLDG8 DN Anatumomab mafenatox DMMLDG8 MI TT70MLA DMMLDG8 MN Oncotrophoblast glycoprotein 5T4 (TPBG) DMMLDG8 MT DTT DMMLDG8 RN A phase II study of a 5T4 oncofoetal antigen tumour-targeted superantigen (ABR-214936) therapy in patients with advanced renal cell carcinoma. Br J Cancer. 2007 Feb 26;96(4):567-74. DMMLDG8 RU https://pubmed.ncbi.nlm.nih.gov/17285137 DM35LJC DI DM35LJC DM35LJC DN Anpirtoline DM35LJC MI TTSQIFT DM35LJC MN 5-HT 1A receptor (HTR1A) DM35LJC MT DTT DM35LJC MA Modulator DM35LJC RN Effects of anpirtoline on regional serotonin synthesis in the rat brain: an autoradiographic study. Nucl Med Biol. 2006 Apr;33(3):325-32. DM35LJC RU https://pubmed.ncbi.nlm.nih.gov/16631081 DM35LJC DI DM35LJC DM35LJC DN Anpirtoline DM35LJC MI TTK8CXU DM35LJC MN 5-HT 1B receptor (HTR1B) DM35LJC MT DTT DM35LJC MA Modulator DM35LJC RN Effects of anpirtoline on regional serotonin synthesis in the rat brain: an autoradiographic study. Nucl Med Biol. 2006 Apr;33(3):325-32. DM35LJC RU https://pubmed.ncbi.nlm.nih.gov/16631081 DM2EKX5 DI DM2EKX5 DM2EKX5 DN Antalarmin DM2EKX5 MI TT7EFHR DM2EKX5 MN Corticotropin-releasing factor receptor 1 (CRHR1) DM2EKX5 MT DTT DM2EKX5 MA Antagonist DM2EKX5 RN Chronic administration of the non-peptide CRH type 1 receptor antagonist antalarmin does not blunt hypothalamic-pituitary-adrenal axis responses to acute immobilization stress. Life Sci. 1999;65(4):PL53-8. DM2EKX5 RU https://pubmed.ncbi.nlm.nih.gov/10421433 DMXI185 DI DMXI185 DMXI185 DN Anti-IFN gamma DMXI185 MI TTG043C DMXI185 MN Tumor necrosis factor receptor type I (TNF-R1) DMXI185 MT DTT DMXI185 RN Secretion of a TNFR:Fc fusion protein following pulmonary administration of pseudotyped adeno-associated virus vectors. J Virol. 2004 Nov;78(22):12355-65. DMXI185 RU https://pubmed.ncbi.nlm.nih.gov/15507622 DMXKZDU DI DMXKZDU DMXKZDU DN Antova DMXKZDU MI TTIJP3Q DMXKZDU MN TNF related activation protein (CD40LG) DMXKZDU MT DTT DMXKZDU MA Modulator DMXKZDU RN CD40 and Autoimmunity: The Dark Side of a Great Activator DMXKZDU RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2753170 DMOJP9E DI DMOJP9E DMOJP9E DN ANX-201 DMOJP9E MI TT84ETX DMOJP9E MN Human immunodeficiency virus Reverse transcriptase (HIV RT) DMOJP9E MT DTT DMOJP9E MA Modulator DMOJP9E RN DOI: 10.1038/scibx.2008.591 DMOJP9E RU http://www.nature.com/scibx/journal/v1/n25/full/scibx.2008.591.html DM5B72D DI DM5B72D DM5B72D DN AP22408 DM5B72D MI TT6PKBN DM5B72D MN Proto-oncogene c-Src (SRC) DM5B72D MT DTT DM5B72D MA Inhibitor DM5B72D RN Structure-based design of an osteoclast-selective, nonpeptide src homology 2 inhibitor with in vivo antiresorptive activity. Proc Natl Acad Sci U S A. 2000 Aug 15;97(17):9373-8. DM5B72D RU https://pubmed.ncbi.nlm.nih.gov/10944210 DM7LAXF DI DM7LAXF DM7LAXF DN AP-227 DM7LAXF MI TTOFYT1 DM7LAXF MN Prostacyclin receptor (PTGIR) DM7LAXF MT DTT DM7LAXF MA Inhibitor DM7LAXF RN Molecular design of novel PGI2 agonists without PG skeleton, Bioorg. Med. Chem. Lett. 5(10):1071-1076 (1995). DM7LAXF RU http://www.sciencedirect.com/science/article/pii/0960894X9500168S DMXLJBA DI DMXLJBA DMXLJBA DN AP-23588 DMXLJBA MI TTJSQEF DMXLJBA MN Tyrosine-protein kinase (PTK) DMXLJBA MT DTT DMXLJBA MA Inhibitor DMXLJBA RN Foye's Principles of Medicinal Chemistry, Thomas L. Lemke, David A. Williams. 2008. Page(950). DMXLJBA RU https://books.google.com.hk/books?id=R0W1ErpsQpkC&pg=PA950&lpg=PA950&dq=%22AP-23588%22++Protein+tyrosine+kinase&source=bl&ots=oCPoj5ZYqs&sig=4H-SJKuzkNOCopt3dSUJP3i2EEA&hl=zh-CN&sa=X&ved=0CCEQ6AEwAWoVChMIv4zt6NC_yAIVEHCOCh3qywXw#v=onepage&q=%22AP-23588%22%20%20Protein%20tyrosine%20kinase&f=false DMBA4DK DI DMBA4DK DMBA4DK DN APC-6336 DMBA4DK MI TT3C1VN DMBA4DK MN Enzyme unspecific (Enz) DMBA4DK MT DTT DMBA4DK MA Inhibitor DMBA4DK RN CN patent application no. 103263414, Application of 2,2'-(1,4-phenylene)di(benzimidazole-5-carboxylic acid) in preparation of antitumor drug. DMBA4DK RU http://www.google.com/patents/CN103263414A?cl=en DMYD04O DI DMYD04O DMYD04O DN APF-580 DMYD04O MI TTN4QDT DMYD04O MN Opioid receptor (OPR) DMYD04O MT DTT DMYD04O MA Modulator DMYD04O RN WO patent application no. 2010,0094,51, Long-acting injectable analgesic formulations for animals. DMYD04O RU http://worldwide.espacenet.com/publicationDetails/biblio?DB=worldwide.espacenet.com&II=0&ND=3&adjacent=true&locale=en_EP&FT=D&date=20100121&CC=WO&NR=2010009451A2&KC=A2 DMIYTPE DI DMIYTPE DMIYTPE DN Apolipoprotein E DMIYTPE MI TTKS9CB DMIYTPE MN Apolipoprotein E (APOE) DMIYTPE MT DTT DMIYTPE MA Modulator DMIYTPE RN Apolipoprotein E: a potent inhibitor of endothelial and tumor cell proliferation. J Cell Biochem. 1994 Mar;54(3):299-308. DMIYTPE RU https://pubmed.ncbi.nlm.nih.gov/8200910 DMPMW03 DI DMPMW03 DMPMW03 DN AQ-RA-741 DMPMW03 MI TTYEG6Q DMPMW03 MN Muscarinic acetylcholine receptor M2 (CHRM2) DMPMW03 MT DTT DMPMW03 MA Modulator DMPMW03 RN Pharmacological profile of selective muscarinic receptor antagonists on guinea-pig ileal smooth muscle. Eur J Pharmacol. 1994 Mar 3;253(3):275-81. DMPMW03 RU https://pubmed.ncbi.nlm.nih.gov/8200421 DMHU1E8 DI DMHU1E8 DMHU1E8 DN AR177 DMHU1E8 MI TT5FH9Y DMHU1E8 MN Human immunodeficiency virus Integrase (HIV IN) DMHU1E8 MT DTT DMHU1E8 MA Inhibitor DMHU1E8 RN Specific inhibition of human immunodeficiency virus type 1 (HIV-1) integration in cell culture: putative inhibitors of HIV-1 integrase. Antimicrob Agents Chemother. 2001 Sep;45(9):2510-6. DMHU1E8 RU https://pubmed.ncbi.nlm.nih.gov/11502522 DMUI81C DI DMUI81C DMUI81C DN AR-709 DMUI81C MI TTV8DM2 DMUI81C MN Bacterial Dihydrofolate reductase (Bact DHFR) DMUI81C MT DTT DMUI81C MA Modulator DMUI81C RN Activity of the Diaminopyrimidine AR-709 against Recently Collected Multidrug-Resistant Isolates of Invasive Streptococcus pneumoniae from North America DMUI81C RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2258536 DMQ52JR DI DMQ52JR DMQ52JR DN ARC239 DMQ52JR MI TT2NUT5 DMQ52JR MN Adrenergic receptor alpha-2C (ADRA2C) DMQ52JR MT DTT DMQ52JR MA Antagonist DMQ52JR RN Potent alpha(2A)-adrenoceptor-mediated vasoconstriction by brimonidine in porcine ciliary arteries. Invest Ophthalmol Vis Sci. 2001 Aug;42(9):2049-55. DMQ52JR RU https://pubmed.ncbi.nlm.nih.gov/11481271 DM9HZ8D DI DM9HZ8D DM9HZ8D DN AR-C-89855 DM9HZ8D MI TT2CJVK DM9HZ8D MN Adrenergic receptor beta-2 (ADRB2) DM9HZ8D MT DTT DM9HZ8D MA Agonist DM9HZ8D RN Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800013263) DM9HZ8D RU http://adisinsight.springer.com/drugs/800013263 DMRXB74 DI DMRXB74 DMRXB74 DN ARISTEROMYCIN DMRXB74 MI TTK25J1 DMRXB74 MN Adenosine A1 receptor (ADORA1) DMRXB74 MT DTT DMRXB74 MA Inhibitor DMRXB74 RN Methanocarba analogues of purine nucleosides as potent and selective adenosine receptor agonists. J Med Chem. 2000 Jun 1;43(11):2196-203. DMRXB74 RU https://pubmed.ncbi.nlm.nih.gov/10841798 DMRXB74 DI DMRXB74 DMRXB74 DN ARISTEROMYCIN DMRXB74 MI TTM2AOE DMRXB74 MN Adenosine A2a receptor (ADORA2A) DMRXB74 MT DTT DMRXB74 MA Inhibitor DMRXB74 RN Methanocarba analogues of purine nucleosides as potent and selective adenosine receptor agonists. J Med Chem. 2000 Jun 1;43(11):2196-203. DMRXB74 RU https://pubmed.ncbi.nlm.nih.gov/10841798 DMRXB74 DI DMRXB74 DMRXB74 DN ARISTEROMYCIN DMRXB74 MI TTE2KUJ DMRXB74 MN Adenosylhomocysteinase (AHCY) DMRXB74 MT DTT DMRXB74 MA Inhibitor DMRXB74 RN Synthesis of 2-modified aristeromycins and their analogs as potent inhibitors against Plasmodium falciparum S-adenosyl-L-homocysteine hydrolase. Bioorg Med Chem. 2008 Apr 1;16(7):3809-15. DMRXB74 RU https://pubmed.ncbi.nlm.nih.gov/18295495 DMRYQBE DI DMRYQBE DMRYQBE DN AS-1406 DMRYQBE MI TTRBUYN DMRYQBE MN Ribonuclease (RNase) DMRYQBE MT DTT DMRYQBE MA Modulator DMRYQBE RN WO patent application no. 2005,0657,17, Liquid formulations of antibody conjugates. DMRYQBE RU http://worldwide.espacenet.com/publicationDetails/biblio?DB=worldwide.espacenet.com&II=0&ND=3&adjacent=true&locale=en_EP&FT=D&date=20050721&CC=WO&NR=2005065717A2&KC=A2 DMH78J6 DI DMH78J6 DMH78J6 DN AS-602305 DMH78J6 MI TTSCIUP DMH78J6 MN Oxytocin receptor (OTR) DMH78J6 MT DTT DMH78J6 MA Antagonist DMH78J6 RN Clinical pipeline report, company report or official report of darkpharma. DMH78J6 RU http://www.darkpharma.nl/uploads/7/3/2/8/7328594/journal.pmed.0050022.pdf DMIFDPL DI DMIFDPL DMIFDPL DN AS-8112 DMIFDPL MI TTPC4TU DMIFDPL MN 5-HT 3A receptor (HTR3A) DMIFDPL MT DTT DMIFDPL MA Antagonist DMIFDPL RN Emerging drugs for chemotherapy-induced emesis. Expert Opin Emerg Drugs. 2006 Mar;11(1):137-51. DMIFDPL RU https://pubmed.ncbi.nlm.nih.gov/16503832 DMIFDPL DI DMIFDPL DMIFDPL DN AS-8112 DMIFDPL MI TT4C8EA DMIFDPL MN Dopamine D3 receptor (D3R) DMIFDPL MT DTT DMIFDPL MA Antagonist DMIFDPL RN Emerging drugs for chemotherapy-induced emesis. Expert Opin Emerg Drugs. 2006 Mar;11(1):137-51. DMIFDPL RU https://pubmed.ncbi.nlm.nih.gov/16503832 DMS2FB3 DI DMS2FB3 DMS2FB3 DN ATLIPROFEN METHYL ESTER DMS2FB3 MI TT8NGED DMS2FB3 MN Prostaglandin G/H synthase 1 (COX-1) DMS2FB3 MT DTT DMS2FB3 MA Modulator DMS2FB3 RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. DMS2FB3 RU https://www.fda.gov/ DMS2FB3 DI DMS2FB3 DMS2FB3 DN ATLIPROFEN METHYL ESTER DMS2FB3 MI TTVKILB DMS2FB3 MN Prostaglandin G/H synthase 2 (COX-2) DMS2FB3 MT DTT DMS2FB3 MA Modulator DMS2FB3 RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. DMS2FB3 RU https://www.fda.gov/ DM4UTXV DI DM4UTXV DM4UTXV DN AVE0675 DM4UTXV MI TTSHG0T DM4UTXV MN Toll-like receptor 9 (TLR9) DM4UTXV MT DTT DM4UTXV MA Agonist DM4UTXV RN Pharma & Vaccines. Product Development Pipeline. April 29 2009. DM4UTXV RU http://en.sanofi-aventis.com/binaries/RD_Phase_III_EN_tcm28-24007.pdf DMD8ZM1 DI DMD8ZM1 DMD8ZM1 DN AWD-23-111 DMD8ZM1 MI TT1VOHK DMD8ZM1 MN Potassium channel unspecific (KC) DMD8ZM1 MT DTT DMD8ZM1 MA Opener DMD8ZM1 RN The new antiarrhythmic substance AWD 23-111 inhibits the delayed rectifier potassium current (IK) in guinea pig ventricular myocytes. Pharmazie. 1999 Jan;54(1):61-8. DMD8ZM1 RU https://pubmed.ncbi.nlm.nih.gov/9987799 DMJH7IX DI DMJH7IX DMJH7IX DN AZD-0275 DMJH7IX MI TTQR8Z6 DMJH7IX MN Chemokine receptor (CHR) DMJH7IX MT DTT DMJH7IX MA Antagonist DMJH7IX RN Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800019127) DMJH7IX RU http://adisinsight.springer.com/drugs/800019127 DMS7INR DI DMS7INR DMS7INR DN AZD-0902 DMS7INR MI TTM7WCE DMS7INR MN Ion channel unspecific (IC) DMS7INR MT DTT DMS7INR MA Antagonist DMS7INR RN Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800019129) DMS7INR RU http://adisinsight.springer.com/drugs/800019129 DMPCFRN DI DMPCFRN DMPCFRN DN AZD-1134 DMPCFRN MI TTK8CXU DMPCFRN MN 5-HT 1B receptor (HTR1B) DMPCFRN MT DTT DMPCFRN MA Antagonist DMPCFRN RN N-methyl-3H3AZ10419369 binding to the 5-HT1B receptor: in vitro characterization and in vivo receptor occupancy. J Pharmacol Exp Ther. 2009 Jul;330(1):342-51. DMPCFRN RU https://pubmed.ncbi.nlm.nih.gov/19401496 DM3WFB5 DI DM3WFB5 DM3WFB5 DN AZD3409 DM3WFB5 MI TTXQKM3 DM3WFB5 MN Farnesyl protein transferase (Ftase) DM3WFB5 MT DTT DM3WFB5 MA Inhibitor DM3WFB5 RN AZD3409 inhibits the growth of breast cancer cells with intrinsic resistance to the EGFR tyrosine kinase inhibitor gefitinib. Breast Cancer Res Treat. 2007 May;102(3):275-82. DM3WFB5 RU https://pubmed.ncbi.nlm.nih.gov/17004112 DMABY43 DI DMABY43 DMABY43 DN AZD-5106 DMABY43 MI TTYO0A3 DMABY43 MN Substance-K receptor (TACR2) DMABY43 MT DTT DMABY43 MA Antagonist DMABY43 RN Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800015341) DMABY43 RU http://adisinsight.springer.com/drugs/800015341 DMQUX28 DI DMQUX28 DMQUX28 DN AZD5672 DMQUX28 MI TT2CEJG DMQUX28 MN C-C chemokine receptor type 5 (CCR5) DMQUX28 MT DTT DMQUX28 MA Antagonist DMQUX28 RN Clinical pipeline report, company report or official report of AstraZeneca (2009). DMQUX28 RU http://www.astrazeneca.com/_mshost3690701/content/resources/media/investors/AZN-Q2-2009/AZN-Q2-2009-Pipeline.pdf DMVP4E5 DI DMVP4E5 DMVP4E5 DN AZD6482 DMVP4E5 MI TTTHBCA DMVP4E5 MN PI3-kinase beta (PIK3CB) DMVP4E5 MT DTT DMVP4E5 MA Modulator DMVP4E5 RN Human target validation of phosphoinositide 3-kinase (PI3K)beta: effects on platelets and insulin sensitivity, using AZD6482 a novel PI3Kbeta inhibitor. J Thromb Haemost. 2012 Oct;10(10):2127-36. DMVP4E5 RU https://pubmed.ncbi.nlm.nih.gov/22906130 DMZ90OV DI DMZ90OV DMZ90OV DN AZD-6942 DMZ90OV MI TTFZYTO DMZ90OV MN C-C chemokine receptor type 2 (CCR2) DMZ90OV MT DTT DMZ90OV MA Antagonist DMZ90OV RN Patent EP2727944 A1. DMZ90OV RU http://www.google.com/patents/EP2727944A1?cl=en DMU6L4I DI DMU6L4I DMU6L4I DN AZD-7545 DMU6L4I MI TTJGCKM DMU6L4I MN Pyruvate dehydrogenase kinase 2 (PDHK2) DMU6L4I MT DTT DMU6L4I MA Inhibitor DMU6L4I RN Recognition of the inner lipoyl-bearing domain of dihydrolipoyl transacetylase and of the blood glucose-lowering compound AZD7545 by pyruvate dehyd... Biochemistry. 2007 Jul 24;46(29):8592-602. DMU6L4I RU https://pubmed.ncbi.nlm.nih.gov/17602666 DMFE3CD DI DMFE3CD DMFE3CD DN AZD-9935 DMFE3CD MI TTGKNB4 DMFE3CD MN Epidermal growth factor receptor (EGFR) DMFE3CD MT DTT DMFE3CD MA Antagonist DMFE3CD RN WO patent application no. 2009,0582,67, Benzomorpholine derivatives and methods of use. DMFE3CD RU http://worldwide.espacenet.com/publicationDetails/biblio?DB=worldwide.espacenet.com&II=0&ND=3&adjacent=true&locale=en_EP&FT=D&date=20090507&CC=WO&NR=2009058267A2&KC=A2 DMFE3CD DI DMFE3CD DMFE3CD DN AZD-9935 DMFE3CD MI TTVJ1D8 DMFE3CD MN Vascular endothelial growth factor receptor (VEGFR) DMFE3CD MT DTT DMFE3CD MA Antagonist DMFE3CD RN WO patent application no. 2009,0582,67, Benzomorpholine derivatives and methods of use. DMFE3CD RU http://worldwide.espacenet.com/publicationDetails/biblio?DB=worldwide.espacenet.com&II=0&ND=3&adjacent=true&locale=en_EP&FT=D&date=20090507&CC=WO&NR=2009058267A2&KC=A2 DMLCSRF DI DMLCSRF DMLCSRF DN AZM-131 DMLCSRF MI TTXMY0J DMLCSRF MN Pancreatic triacylglycerol lipase (PNLIP) DMLCSRF MT DTT DMLCSRF MA Modulator DMLCSRF RN US patent application no. 7217,697, Glucopyranosyloxypyrazole derivative medicinal composition containing the same medicinal use thereof and intermediate therefor. DMLCSRF RU http://worldwide.espacenet.com/publicationDetails/biblio?DB=worldwide.espacenet.com&II=0&ND=3&adjacent=true&locale=en_EP&FT=D&date=20040909&CC=US&NR=2004176308A1&KC=A1 DMIWC64 DI DMIWC64 DMIWC64 DN AZM-134 DMIWC64 MI TTVIMDE DMIWC64 MN Glucagon-like peptide 1 receptor (GLP1R) DMIWC64 MT DTT DMIWC64 MA Modulator DMIWC64 RN US patent application no. 2011,0171,312, Modified therapeutic peptides, methods of their preparation and use. DMIWC64 RU http://worldwide.espacenet.com/publicationDetails/biblio?DB=worldwide.espacenet.com&II=0&ND=3&adjacent=true&locale=en_EP&FT=D&date=20110714&CC=US&NR=2011171312A1&KC=A1 DME6OFU DI DME6OFU DME6OFU DN B-428 DME6OFU MI TTGY7WI DME6OFU MN Urokinase-type plasminogen activator (PLAU) DME6OFU MT DTT DME6OFU MA Inhibitor DME6OFU RN Natural and synthetic inhibitors of the tumor-associated serine protease urokinase-type plasminogen activator. Adv Exp Med Biol. 2000;477:331-41. DME6OFU RU https://pubmed.ncbi.nlm.nih.gov/10849761 DM8I5UF DI DM8I5UF DM8I5UF DN B-5354a DM8I5UF MI TTOHFIY DM8I5UF MN Sphingosine kinase 1 (SPHK1) DM8I5UF MT DTT DM8I5UF MA Inhibitor DM8I5UF RN Characterization of B-5354c, a new sphingosine kinase inhibitor, produced by a marine bacterium. J Antibiot (Tokyo). 2000 Aug;53(8):759-64. DM8I5UF RU https://pubmed.ncbi.nlm.nih.gov/11079797 DM5EKPM DI DM5EKPM DM5EKPM DN B-581 DM5EKPM MI TTV8ETH DM5EKPM MN Protein prenyl transferase (PPTF) DM5EKPM MT DTT DM5EKPM MA Inhibitor DM5EKPM RN Spectroscopic study of fluorescent peptides for prenyl transferase assays. J Pharm Biomed Anal. 2005 Mar 9;37(3):417-22. DM5EKPM RU https://pubmed.ncbi.nlm.nih.gov/15740898 DM1IO9X DI DM1IO9X DM1IO9X DN B-956 DM1IO9X MI TT7WZIJ DM1IO9X MN CAAX farnesyltransferase beta (FNTB) DM1IO9X MT DTT DM1IO9X MA Modulator DM1IO9X RN Inhibition of human tumor xenograft growth by treatment with the farnesyl transferase inhibitor B956. Cancer Res. 1995 Nov 15;55(22):5310-4. DM1IO9X RU https://pubmed.ncbi.nlm.nih.gov/7585593 DM8AGOE DI DM8AGOE DM8AGOE DN BABIM DM8AGOE MI TTM1TDX DM8AGOE MN Tryptase alpha/beta-1 (Tryptase) DM8AGOE MT DTT DM8AGOE MA Inhibitor DM8AGOE RN Inhibitors of tryptase for the treatment of mast cell-mediated diseases. Curr Pharm Des. 1998 Oct;4(5):381-96. DM8AGOE RU https://pubmed.ncbi.nlm.nih.gov/10197050 DMY1TLZ DI DMY1TLZ DMY1TLZ DN Baicalin DMY1TLZ MI TTNGKET DMY1TLZ MN Prolyl endopeptidase (PREP) DMY1TLZ MT DTT DMY1TLZ MA Inhibitor DMY1TLZ RN Inhibitors of prolyl oligopeptidases for the therapy of human diseases: defining diseases and inhibitors. J Med Chem. 2010 May 13;53(9):3423-38. DMY1TLZ RU https://pubmed.ncbi.nlm.nih.gov/20058865 DMDLN9E DI DMDLN9E DMDLN9E DN BALANOL DMDLN9E MI TTW4Y2M DMDLN9E MN cAMP protein kinase type II-beta (PRKAR2B) DMDLN9E MT DTT DMDLN9E MA Inhibitor DMDLN9E RN Joys of molecules. 2. Endeavors in chemical biology and medicinal chemistry. J Med Chem. 2005 Sep 8;48(18):5613-38. Address; DMDLN9E RU https://pubmed.ncbi.nlm.nih.gov/16134928 DMDLN9E DI DMDLN9E DMDLN9E DN BALANOL DMDLN9E MI TTER6YH DMDLN9E MN Casein kinase II alpha (CSNK2A1) DMDLN9E MT DTT DMDLN9E MA Inhibitor DMDLN9E RN Synthesis and protein kinase C inhibitory activities of acyclic balanol analogs that are highly selective for protein kinase C over protein kinase A. J Med Chem. 1996 Dec 20;39(26):5215-27. DMDLN9E RU https://pubmed.ncbi.nlm.nih.gov/8978850 DMDLN9E DI DMDLN9E DMDLN9E DN BALANOL DMDLN9E MI TTYVI76 DMDLN9E MN Fungal Protein kinase A (Fung ypkA) DMDLN9E MT DTT DMDLN9E MA Inhibitor DMDLN9E RN Joys of molecules. 2. Endeavors in chemical biology and medicinal chemistry. J Med Chem. 2005 Sep 8;48(18):5613-38. Address; DMDLN9E RU https://pubmed.ncbi.nlm.nih.gov/16134928 DMDLN9E DI DMDLN9E DMDLN9E DN BALANOL DMDLN9E MI TT7A1BO DMDLN9E MN PKC-delta messenger RNA (PRKCD mRNA) DMDLN9E MT DTT DMDLN9E MA Inhibitor DMDLN9E RN Evaluation of differential hypoxic cytotoxicity and electrochemical studies of nitro 5-deazaflavins, Bioorg. Med. Chem. Lett. 5(18):2155-2160 (1995). DMDLN9E RU http://www.sciencedirect.com/science/article/pii/0960894X9500352T DMDLN9E DI DMDLN9E DMDLN9E DN BALANOL DMDLN9E MI TT57MT2 DMDLN9E MN PKC-epsilon messenger RNA (PRKCE mRNA) DMDLN9E MT DTT DMDLN9E MA Inhibitor DMDLN9E RN Evaluation of differential hypoxic cytotoxicity and electrochemical studies of nitro 5-deazaflavins, Bioorg. Med. Chem. Lett. 5(18):2155-2160 (1995). DMDLN9E RU http://www.sciencedirect.com/science/article/pii/0960894X9500352T DMDLN9E DI DMDLN9E DMDLN9E DN BALANOL DMDLN9E MI TTONI0R DMDLN9E MN PKC-eta messenger RNA (PRKCH mRNA) DMDLN9E MT DTT DMDLN9E MA Inhibitor DMDLN9E RN Evaluation of differential hypoxic cytotoxicity and electrochemical studies of nitro 5-deazaflavins, Bioorg. Med. Chem. Lett. 5(18):2155-2160 (1995). DMDLN9E RU http://www.sciencedirect.com/science/article/pii/0960894X9500352T DMDLN9E DI DMDLN9E DMDLN9E DN BALANOL DMDLN9E MI TTBSN0L DMDLN9E MN PKC-zeta messenger RNA (PRKCZ mRNA) DMDLN9E MT DTT DMDLN9E MA Inhibitor DMDLN9E RN Evaluation of differential hypoxic cytotoxicity and electrochemical studies of nitro 5-deazaflavins, Bioorg. Med. Chem. Lett. 5(18):2155-2160 (1995). DMDLN9E RU http://www.sciencedirect.com/science/article/pii/0960894X9500352T DMDLN9E DI DMDLN9E DMDLN9E DN BALANOL DMDLN9E MI TT5U49F DMDLN9E MN PRKACA messenger RNA (PRKACA mRNA) DMDLN9E MT DTT DMDLN9E MA Inhibitor DMDLN9E RN Joys of molecules. 2. Endeavors in chemical biology and medicinal chemistry. J Med Chem. 2005 Sep 8;48(18):5613-38. Address; DMDLN9E RU https://pubmed.ncbi.nlm.nih.gov/16134928 DMDLN9E DI DMDLN9E DMDLN9E DN BALANOL DMDLN9E MI TTFJ8Q1 DMDLN9E MN Protein kinase C alpha (PRKCA) DMDLN9E MT DTT DMDLN9E MA Inhibitor DMDLN9E RN Evaluation of differential hypoxic cytotoxicity and electrochemical studies of nitro 5-deazaflavins, Bioorg. Med. Chem. Lett. 5(18):2155-2160 (1995). DMDLN9E RU http://www.sciencedirect.com/science/article/pii/0960894X9500352T DMDLN9E DI DMDLN9E DMDLN9E DN BALANOL DMDLN9E MI TTYPXQF DMDLN9E MN Protein kinase C beta (PRKCB) DMDLN9E MT DTT DMDLN9E MA Inhibitor DMDLN9E RN Evaluation of differential hypoxic cytotoxicity and electrochemical studies of nitro 5-deazaflavins, Bioorg. Med. Chem. Lett. 5(18):2155-2160 (1995). DMDLN9E RU http://www.sciencedirect.com/science/article/pii/0960894X9500352T DMDLN9E DI DMDLN9E DMDLN9E DN BALANOL DMDLN9E MI TTRFOXJ DMDLN9E MN Protein kinase C gamma (PRKCG) DMDLN9E MT DTT DMDLN9E MA Inhibitor DMDLN9E RN Evaluation of differential hypoxic cytotoxicity and electrochemical studies of nitro 5-deazaflavins, Bioorg. Med. Chem. Lett. 5(18):2155-2160 (1995). DMDLN9E RU http://www.sciencedirect.com/science/article/pii/0960894X9500352T DMTMS3L DI DMTMS3L DMTMS3L DN Barucainide DMTMS3L MI TT05DLS DMTMS3L MN E3 ubiquitin-protein ligase COP1 (RFWD2) DMTMS3L MT DTT DMTMS3L MA Modulator DMTMS3L RN Barucainide, a novel class Ib antiarrhythmic agent with a slow kinetic property: electrophysiologic observations in isolated canine and rabbit cardiac muscle. Am Heart J. 1990 May;119(5):1050-60. DMTMS3L RU https://pubmed.ncbi.nlm.nih.gov/2330863 DM7LZFQ DI DM7LZFQ DM7LZFQ DN BAY-17-1998 DM7LZFQ MI TTM1TDX DM7LZFQ MN Tryptase alpha/beta-1 (Tryptase) DM7LZFQ MT DTT DM7LZFQ MA Modulator DM7LZFQ RN Bayer AG to Develop Arris Asthma Compound; Arris to Receive Milestone Payment. 1996 Business Wire DM7LZFQ RU http://www.thefreelibrary.com/Axys+Pharmaceuticals+Announces+Bayer+AG's+Decision+to+Discontinue...-a062275428 DMPUG18 DI DMPUG18 DMPUG18 DN BAY-39-9624 DMPUG18 MI TTUV8G9 DMPUG18 MN Progesterone receptor (PGR) DMPUG18 MT DTT DMPUG18 MA Agonist DMPUG18 RN Bayer is seeking an exclusive licensee for its end-of-Phase I progestinagonist Bay 39-9624. Thepharmaletter. 29-04-2002. DMPUG18 RU http://www.thepharmaletter.com/article/bayer-offers-license-opportunity DM40ORU DI DM40ORU DM40ORU DN BAY-44-3428 DM40ORU MI TTM1TDX DM40ORU MN Tryptase alpha/beta-1 (Tryptase) DM40ORU MT DTT DM40ORU MA Inhibitor DM40ORU RN Bayer AG to Develop Arris Asthma Compound; Arris to Receive Milestone Payment. 1996 Business Wire DM40ORU RU http://www.thefreelibrary.com/Axys+Pharmaceuticals+Announces+Bayer+AG's+Decision+to+Discontinue...-a062275428 DMAKXN3 DI DMAKXN3 DMAKXN3 DN BAY-50-9062 DMAKXN3 MI TTVC5K6 DMAKXN3 MN Estradiol 17 beta-dehydrogenase (17-beta-HSD) DMAKXN3 MT DTT DMAKXN3 MA Inhibitor DMAKXN3 RN Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800015540) DMAKXN3 RU http://adisinsight.springer.com/drugs/800015540 DM69EHF DI DM69EHF DM69EHF DN BAY-793 DM69EHF MI TT5FNQT DM69EHF MN Human immunodeficiency virus Protease (HIV PR) DM69EHF MT DTT DM69EHF MA Modulator DM69EHF RN HIV protease inhibitor HOE/BAY 793, structure-activity relationships in a series of C2-symmetric diols. Bioorg Med Chem. 1995 May;3(5):559-71. DM69EHF RU https://pubmed.ncbi.nlm.nih.gov/7648204 DMZGFM6 DI DMZGFM6 DMZGFM6 DN BAY-Z-4305 DMZGFM6 MI TT84ETX DMZGFM6 MN Human immunodeficiency virus Reverse transcriptase (HIV RT) DMZGFM6 MT DTT DMZGFM6 MA Inhibitor DMZGFM6 RN US patent application no. 2008,0161,324, Compositions and methods for treatment of viral diseases. DMZGFM6 RU http://www.google.com/patents/US20080161324 DM7GH5Z DI DM7GH5Z DM7GH5Z DN BB-1101 DM7GH5Z MI TTMX39J DM7GH5Z MN Matrix metalloproteinase-1 (MMP-1) DM7GH5Z MT DTT DM7GH5Z MA Inhibitor DM7GH5Z RN Broad spectrum matrix metalloproteinase inhibitors: an examination of succinamide hydroxamate inhibitors with P1 C alpha gem-disubstitution. Bioorg Med Chem Lett. 1998 Jun 16;8(12):1443-8. DM7GH5Z RU https://pubmed.ncbi.nlm.nih.gov/9873367 DM7GH5Z DI DM7GH5Z DM7GH5Z DN BB-1101 DM7GH5Z MI TTLM12X DM7GH5Z MN Matrix metalloproteinase-2 (MMP-2) DM7GH5Z MT DTT DM7GH5Z MA Inhibitor DM7GH5Z RN Broad spectrum matrix metalloproteinase inhibitors: an examination of succinamide hydroxamate inhibitors with P1 C alpha gem-disubstitution. Bioorg Med Chem Lett. 1998 Jun 16;8(12):1443-8. DM7GH5Z RU https://pubmed.ncbi.nlm.nih.gov/9873367 DM7GH5Z DI DM7GH5Z DM7GH5Z DN BB-1101 DM7GH5Z MI TTUZ2L5 DM7GH5Z MN Matrix metalloproteinase-3 (MMP-3) DM7GH5Z MT DTT DM7GH5Z MA Inhibitor DM7GH5Z RN Broad spectrum matrix metalloproteinase inhibitors: an examination of succinamide hydroxamate inhibitors with P1 C alpha gem-disubstitution. Bioorg Med Chem Lett. 1998 Jun 16;8(12):1443-8. DM7GH5Z RU https://pubmed.ncbi.nlm.nih.gov/9873367 DM7GH5Z DI DM7GH5Z DM7GH5Z DN BB-1101 DM7GH5Z MI TTGA1IV DM7GH5Z MN Matrix metalloproteinase-8 (MMP-8) DM7GH5Z MT DTT DM7GH5Z MA Inhibitor DM7GH5Z RN New alpha-substituted succinate-based hydroxamic acids as TNFalpha convertase inhibitors. J Med Chem. 1999 Nov 18;42(23):4890-908. DM7GH5Z RU https://pubmed.ncbi.nlm.nih.gov/10579851 DMWAKC8 DI DMWAKC8 DMWAKC8 DN BB-1433 DMWAKC8 MI TT1GHVO DMWAKC8 MN Matrix metalloproteinase (MMP) DMWAKC8 MT DTT DMWAKC8 MA Inhibitor DMWAKC8 RN Anti-arthritic activity of hydroxamic acid-based pseudopeptide inhibitors of matrix metalloproteinases and TNF alpha processing. Inflamm Res. 1997 Jun;46(6):211-5. DMWAKC8 RU https://pubmed.ncbi.nlm.nih.gov/9243304 DM6ETM8 DI DM6ETM8 DM6ETM8 DN BB-2275 DM6ETM8 MI TTZXH48 DM6ETM8 MN TNF receptor (TNFR) DM6ETM8 MT DTT DM6ETM8 MA Modulator DM6ETM8 RN Paradoxical effects of a synthetic metalloproteinase inhibitor that blocks both p55 and p75 TNF receptor shedding and TNF alpha processing in RA sy... J Clin Invest. 1996 Jun 15;97(12):2833-41. DM6ETM8 RU https://www.ncbi.nlm.nih.gov/pubmed/8675695 DM7YRFE DI DM7YRFE DM7YRFE DN BB-3644 DM7YRFE MI TTMX39J DM7YRFE MN Matrix metalloproteinase-1 (MMP-1) DM7YRFE MT DTT DM7YRFE MA Inhibitor DM7YRFE RN Tumour microenvironment - opinion: validating matrix metalloproteinases as drug targets and anti-targets for cancer therapy. Nat Rev Cancer. 2006 Mar;6(3):227-39. DM7YRFE RU https://pubmed.ncbi.nlm.nih.gov/16498445 DM7YRFE DI DM7YRFE DM7YRFE DN BB-3644 DM7YRFE MI TTLM12X DM7YRFE MN Matrix metalloproteinase-2 (MMP-2) DM7YRFE MT DTT DM7YRFE MA Inhibitor DM7YRFE RN Tumour microenvironment - opinion: validating matrix metalloproteinases as drug targets and anti-targets for cancer therapy. Nat Rev Cancer. 2006 Mar;6(3):227-39. DM7YRFE RU https://pubmed.ncbi.nlm.nih.gov/16498445 DM7YRFE DI DM7YRFE DM7YRFE DN BB-3644 DM7YRFE MI TTMTWOS DM7YRFE MN Matrix metalloproteinase-7 (MMP-7) DM7YRFE MT DTT DM7YRFE MA Inhibitor DM7YRFE RN Tumour microenvironment - opinion: validating matrix metalloproteinases as drug targets and anti-targets for cancer therapy. Nat Rev Cancer. 2006 Mar;6(3):227-39. DM7YRFE RU https://pubmed.ncbi.nlm.nih.gov/16498445 DMITV4F DI DMITV4F DMITV4F DN BBB-022 DMITV4F MI TTUST1O DMITV4F MN Phosphodiesterase (PDE) DMITV4F MT DTT DMITV4F MA Inhibitor DMITV4F RN Matrix metalloproteinase inhibition prevents oxidative stress-associated blood-brain barrier disruption after transient focal cerebral ischemia. J Cereb Blood Flow Metab. 2001 Dec;21(12):1393-400. DMITV4F RU https://pubmed.ncbi.nlm.nih.gov/11740200 DMNH9A6 DI DMNH9A6 DMNH9A6 DN BCH-150 DMNH9A6 MI TTKWM86 DMNH9A6 MN Opioid receptor mu (MOP) DMNH9A6 MT DTT DMNH9A6 MA Modulator DMNH9A6 RN Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800003724) DMNH9A6 RU http://adisinsight.springer.com/drugs/800003724 DM3TP8X DI DM3TP8X DM3TP8X DN BCH-2763 DM3TP8X MI TT6L509 DM3TP8X MN Coagulation factor IIa (F2) DM3TP8X MT DTT DM3TP8X MA Inhibitor DM3TP8X RN BCH-2763, a novel potent parenteral thrombin inhibitor, is an effective antithrombotic agent in rodent models of arterial and venous thrombosis--comparisons with heparin, r-hirudin, hirulog, inogatran and argatroban. Thromb Haemost. 1998 Feb;79(2):431-8. DM3TP8X RU https://pubmed.ncbi.nlm.nih.gov/9493603 DMBJERO DI DMBJERO DMBJERO DN BCX-140 DMBJERO MI TT50QJ3 DMBJERO MN Influenza Neuraminidase (Influ NA) DMBJERO MT DTT DMBJERO MA Inhibitor DMBJERO RN CN patent application no. 104447481, Benzoic acid thiourea anti-influenza virus compounds as well as preparation method and use thereof. DMBJERO RU http://www.google.com/patents/CN104447481A?cl=en DM4GEUF DI DM4GEUF DM4GEUF DN BCX-25 DM4GEUF MI TTX2N1T DM4GEUF MN Transferase unspecific (TF) DM4GEUF MT DTT DM4GEUF MA Modulator DM4GEUF RN CN patent application no. 1096855, Composition produced by treatment and induction of nitrogen mono oxide synthase expressed matter, and use thereof. DM4GEUF RU http://www.google.com/patents/CN1096855C?cl=en DMV5K0I DI DMV5K0I DMV5K0I DN BDF-9148 DMV5K0I MI TTRK8B9 DMV5K0I MN Sodium channel unspecific (NaC) DMV5K0I MT DTT DMV5K0I MA Modulator DMV5K0I RN The relaxing effect of BDF 9148 on the KCl-contracted aorta isolated from normo- and hyper-tensive rats. Naunyn Schmiedebergs Arch Pharmacol. 1998 Feb;357(2):126-32. DMV5K0I RU https://pubmed.ncbi.nlm.nih.gov/9521485 DM6WQ8F DI DM6WQ8F DM6WQ8F DN BE-13793C DM6WQ8F MI TTGTQHC DM6WQ8F MN DNA topoisomerase I (TOP1) DM6WQ8F MT DTT DM6WQ8F MA Modulator DM6WQ8F RN DOI: 10.1002/3527601783.ch20 DM6WQ8F RU http://onlinelibrary.wiley.com/doi/10.1002/3527601783.ch20/pdf DM1SVQX DI DM1SVQX DM1SVQX DN BE-16627B DM1SVQX MI TT1GHVO DM1SVQX MN Matrix metalloproteinase (MMP) DM1SVQX MT DTT DM1SVQX MA Modulator DM1SVQX RN Gelatinase B (MMP-9), but not its inhibitor (TIMP-1), dictates the growth rate of experimental thymic lymphoma. Int J Cancer. 1999 Aug 27;82(5):743-7. DM1SVQX RU https://pubmed.ncbi.nlm.nih.gov/10417774 DM39SEK DI DM39SEK DM39SEK DN BE-22179 DM39SEK MI TT0IHXV DM39SEK MN DNA topoisomerase II (TOP2) DM39SEK MT DTT DM39SEK MA Modulator DM39SEK RN A new topoisomerase II inhibitor, BE-22179, produced by a streptomycete. I. Producing strain, fermentation, isolation and biological activity. J Antibiot (Tokyo). 1994 Feb;47(2):129-35. DM39SEK RU https://pubmed.ncbi.nlm.nih.gov/8150706 DM6KRJW DI DM6KRJW DM6KRJW DN BEA-005 DM6KRJW MI TT84ETX DM6KRJW MN Human immunodeficiency virus Reverse transcriptase (HIV RT) DM6KRJW MT DTT DM6KRJW MA Modulator DM6KRJW RN Efficacy of Postexposure Prophylaxis after Intravaginal Exposure of Pig-Tailed Macaques to a Human-Derived Retrovirus (Human Immunodeficiency Virus Type 2). J Virol. 2000 October; 74(20): 9771-9775. DM6KRJW RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC112413/ DMGAPH1 DI DMGAPH1 DMGAPH1 DN Befiperide DMGAPH1 MI TTWT5K7 DMGAPH1 MN 5-HT 1 receptor (5HT1R) DMGAPH1 MT DTT DMGAPH1 MA Modulator DMGAPH1 RN Behavioral Pharmacology of 5-ht. Paul Bevan, Paul Bevan Duphar, Alexander R. Cools. 2013. Figure(15.2). DMGAPH1 RU https://books.google.com.hk/books?id=oJIFi5E-YI0C&pg=PT294&lpg=PT294&dq=befiperide+++5HT&source=bl&ots=MsOmWqq_Lp&sig=XqN92Fe4GBpDtwToXK7DG-tUXVk&hl=zh-CN&sa=X&ved=0CBwQ6AEwAGoVChMIq4aV3uy8yAIVDsWOCh0H6AMC#v=onepage&q=befiperide%20%20%205HT&f=false DMM0ZIJ DI DMM0ZIJ DMM0ZIJ DN Belaperidone DMM0ZIJ MI TTE0A2F DMM0ZIJ MN Dopamine D4 receptor (D4R) DMM0ZIJ MT DTT DMM0ZIJ MA Antagonist DMM0ZIJ RN The pipeline and future of drug development in schizophrenia. Mol Psychiatry. 2007 Oct;12(10):904-22. DMM0ZIJ RU https://pubmed.ncbi.nlm.nih.gov/17667958 DMXH3A2 DI DMXH3A2 DMXH3A2 DN Benafentrine dimaleate DMXH3A2 MI TTZCG4L DMXH3A2 MN Phosphodiesterase 3 (PDE3) DMXH3A2 MT DTT DMXH3A2 MA Modulator DMXH3A2 RN Studies on anti-allergic action of AH 21-132, a novel isozyme-selective phosphodiesterase inhibitor in airways. Jpn J Pharmacol. 1995 Feb;67(2):149-56. DMXH3A2 RU https://pubmed.ncbi.nlm.nih.gov/7542355 DMVK78Q DI DMVK78Q DMVK78Q DN Bepafant DMVK78Q MI TTQL5VC DMVK78Q MN Platelet-activating factor receptor (PTAFR) DMVK78Q MT DTT DMVK78Q MA Antagonist DMVK78Q RN Pharmacologic activity of bepafant (WEB 2170), a new and selective hetrazepinoic antagonist of platelet activating factor. J Pharmacol Exp Ther. 1990 Dec;255(3):962-8. DMVK78Q RU https://pubmed.ncbi.nlm.nih.gov/2262914 DMXRTFM DI DMXRTFM DMXRTFM DN Ber-H2/saporin DMXRTFM MI TT2GM5R DMXRTFM MN Lymphocyte activation antigen CD30 (TNFRSF8) DMXRTFM MT DTT DMXRTFM RN Antitumor activity of anti-CD30 immunotoxin (Ber-H2/saporin) in vitro and in severe combined immunodeficiency disease mice xenografted with human CD30+ anaplastic large-cell lymphoma. Blood. 1995 Apr15;85(8):2139-46. DMXRTFM RU https://pubmed.ncbi.nlm.nih.gov/7718885 DMQA4JU DI DMQA4JU DMQA4JU DN Berlafenone DMQA4JU MI TTRK8B9 DMQA4JU MN Sodium channel unspecific (NaC) DMQA4JU MT DTT DMQA4JU MA Modulator DMQA4JU RN WO patent application no. 19990639849, Novel sodium channel drugs and uses. DMQA4JU RU http://www.google.com/patents/WO1999063984A9?cl=en DM56WD3 DI DM56WD3 DM56WD3 DN Bertosamil DM56WD3 MI TTQ6VDM DM56WD3 MN Voltage-gated potassium channel Kv11.1 (KCNH2) DM56WD3 MT DTT DM56WD3 MA Modulator DM56WD3 RN Bertosamil blocks HERG potassium channels in their open and inactivated states. Br J Pharmacol. 2002 Sep;137(2):221-8. DM56WD3 RU https://pubmed.ncbi.nlm.nih.gov/12208779 DMH7YD4 DI DMH7YD4 DMH7YD4 DN Bexlosteride DMH7YD4 MI TTTU72V DMH7YD4 MN Steroid 5-alpha-reductase 1 (SRD5A1) DMH7YD4 MT DTT DMH7YD4 MA Inhibitor DMH7YD4 RN Synthesis of 8-chloro-benzo[c]quinolizin-3-ones as potent and selective inhibitors of human steroid 5alpha-reductase 1. Bioorg Med Chem Lett. 2000 Feb 21;10(4):353-6. DMH7YD4 RU https://pubmed.ncbi.nlm.nih.gov/10714498 DM6QT9P DI DM6QT9P DM6QT9P DN BIBB-515 DM6QT9P MI TT7O8ZA DM6QT9P MN Lanosterol synthase (LSS) DM6QT9P MT DTT DM6QT9P MA Modulator DM6QT9P RN Effects of a novel 2,3-oxidosqualene cyclase inhibitor on cholesterol biosynthesis and lipid metabolism in vivo. J Lipid Res. 1997 Mar;38(3):564-75. DM6QT9P RU https://pubmed.ncbi.nlm.nih.gov/9101437 DM019Y7 DI DM019Y7 DM019Y7 DN BIBN-140 DM019Y7 MI TTYEG6Q DM019Y7 MN Muscarinic acetylcholine receptor M2 (CHRM2) DM019Y7 MT DTT DM019Y7 MA Modulator DM019Y7 RN Therapeutic potential of CNS-active M2 antagonists: novel structures and pharmacology. Life Sci. 1993;52(5-6):497-503. DM019Y7 RU https://pubmed.ncbi.nlm.nih.gov/8441330 DMZTPCX DI DMZTPCX DMZTPCX DN BIBN-99 DMZTPCX MI TTYEG6Q DMZTPCX MN Muscarinic acetylcholine receptor M2 (CHRM2) DMZTPCX MT DTT DMZTPCX MA Modulator DMZTPCX RN Characterization of BIBN 99: a lipophilic and selective muscarinic M2 receptor antagonist. Eur J Pharmacol. 1993 Sep 21;242(1):23-30. DMZTPCX RU https://pubmed.ncbi.nlm.nih.gov/8223934 DMYBR9D DI DMYBR9D DMYBR9D DN BIBP 3226 DMYBR9D MI TTRK9JT DMYBR9D MN Neuropeptide Y receptor type 1 (NPY1R) DMYBR9D MT DTT DMYBR9D MA Antagonist DMYBR9D RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 305). DMYBR9D RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=305 DM5107E DI DM5107E DM5107E DN BIBS-222 DM5107E MI TTGN1ZA DM5107E MN Angiotensin II receptor (AGTR) DM5107E MT DTT DM5107E MA Modulator DM5107E RN Characterization of BIBS 39 and BIBS 222: two new nonpeptide angiotensin II receptor antagonists. Eur J Pharmacol. 1992 Jul 21;218(1):35-41. DM5107E RU https://pubmed.ncbi.nlm.nih.gov/1397034 DM098BL DI DM098BL DM098BL DN BIBS-39 DM098BL MI TTGN1ZA DM098BL MN Angiotensin II receptor (AGTR) DM098BL MT DTT DM098BL MA Modulator DM098BL RN Characterization of BIBS 39 and BIBS 222: two new nonpeptide angiotensin II receptor antagonists. Eur J Pharmacol. 1992 Jul 21;218(1):35-41. DM098BL RU https://pubmed.ncbi.nlm.nih.gov/1397034 DMMNI5K DI DMMNI5K DMMNI5K DN BIBU-251 DMMNI5K MI TT38RM1 DMMNI5K MN Glycoprotein IIb/IIIa receptor (GPIIb/IIIa) DMMNI5K MT DTT DMMNI5K MA Modulator DMMNI5K RN CN patent application no. 101312747, Anticoagulant antithrombotic dual inhibitors comprising a biotin label. DMMNI5K RU http://worldwide.espacenet.com/publicationDetails/biblio?DB=worldwide.espacenet.com&II=0&ND=3&adjacent=true&locale=en_EP&FT=D&date=20081126&CC=CN&NR=101312747A&KC=A DMXIH3Q DI DMXIH3Q DMXIH3Q DN BIBW-22 DMXIH3Q MI TTHQENC DMXIH3Q MN Phosphodiesterase 1 (PDE1) DMXIH3Q MT DTT DMXIH3Q MA Inhibitor DMXIH3Q RN BIBW22 BS, potent multidrug resistance-reversing agent, binds directly to P-glycoprotein and accumulates in drug-resistant cells. Mol Pharmacol. 1996 Sep;50(3):482-92. DMXIH3Q RU https://pubmed.ncbi.nlm.nih.gov/8794885 DMRXWCO DI DMRXWCO DMRXWCO DN BIBX-79 DMRXWCO MI TT7O8ZA DMRXWCO MN Lanosterol synthase (LSS) DMRXWCO MT DTT DMRXWCO MA Modulator DMRXWCO RN Effects of a novel 2,3-oxidosqualene cyclase inhibitor on the regulation of cholesterol biosynthesis in HepG2 cells. J Lipid Res. 1996 Jan;37(1):148-58. DMRXWCO RU https://pubmed.ncbi.nlm.nih.gov/8820110 DMU73F0 DI DMU73F0 DMU73F0 DN Bifemelane DMU73F0 MI TT3WG5C DMU73F0 MN Monoamine oxidase type A (MAO-A) DMU73F0 MT DTT DMU73F0 MA Modulator DMU73F0 RN 4-(O-benzylphenoxy)-N-methylbutylamine (bifemelane) and other 4-(O-benzylphenoxy)-N-methylalkylamines as new inhibitors of type A and B monoamine oxidase. J Neurochem. 1988 Jan;50(1):243-7. DMU73F0 RU https://pubmed.ncbi.nlm.nih.gov/3335842 DMBR48G DI DMBR48G DMBR48G DN BI-L-357 DMBR48G MI TT2J34L DMBR48G MN Arachidonate 5-lipoxygenase (5-LOX) DMBR48G MT DTT DMBR48G MA Inhibitor DMBR48G RN A prodrug of a 2,6-disubstituted 4-(2-arylethenyl)phenol is a selective and orally active 5-lipoxygenase inhibitor. J Pharmacol Exp Ther. 1993 May;265(2):483-9. DMBR48G RU https://pubmed.ncbi.nlm.nih.gov/8388452 DMRV4UL DI DMRV4UL DMRV4UL DN BILA-2157BS DMRV4UL MI TTB2MXP DMRV4UL MN Angiotensinogenase renin (REN) DMRV4UL MT DTT DMRV4UL MA Inhibitor DMRV4UL RN Comparative studies on differential inhibition of the renin - angiotensin system in the anesthetized guinea pig. Can J Physiol Pharmacol. 1995 Oct;73(10):1512-8. DMRV4UL RU https://pubmed.ncbi.nlm.nih.gov/8748944 DMUOPBF DI DMUOPBF DMUOPBF DN BILD-1263 DMUOPBF MI TTMJX4U DMUOPBF MN Herpes simplex virus Ribonucleoside-diphosphate reductase (HSV RIR1) DMUOPBF MT DTT DMUOPBF MA Inhibitor DMUOPBF RN Evaluation of a peptidomimetic ribonucleotide reductase inhibitor with a murine model of herpes simplex virus type 1 ocular disease. Antimicrob Agents Chemother. 1996 May;40(5):1078-84. DMUOPBF RU https://pubmed.ncbi.nlm.nih.gov/8723444 DMR01WE DI DMR01WE DMR01WE DN BILD-1351 DMR01WE MI TTMJX4U DMR01WE MN Herpes simplex virus Ribonucleoside-diphosphate reductase (HSV RIR1) DMR01WE MT DTT DMR01WE MA Inhibitor DMR01WE RN The antiviral activity of the ribonucleotide reductase inhibitor BILD 1351 SE in combination with acyclovir against HSV type-1 in cell culture. Antiviral Res. 1998 Jul;39(1):35-46. DMR01WE RU https://pubmed.ncbi.nlm.nih.gov/9754948 DMZMUG2 DI DMZMUG2 DMZMUG2 DN BILD-1357 DMZMUG2 MI TTMJX4U DMZMUG2 MN Herpes simplex virus Ribonucleoside-diphosphate reductase (HSV RIR1) DMZMUG2 MT DTT DMZMUG2 MA Inhibitor DMZMUG2 RN Peptidomimetic inhibitors of herpes simplex virus ribonucleotide reductase with improved in vivo antiviral activity. J Med Chem. 1996 Oct 11;39(21):4173-80. DMZMUG2 RU https://pubmed.ncbi.nlm.nih.gov/8863795 DMAU5WL DI DMAU5WL DMAU5WL DN BILD-733 DMAU5WL MI TTMJX4U DMAU5WL MN Herpes simplex virus Ribonucleoside-diphosphate reductase (HSV RIR1) DMAU5WL MT DTT DMAU5WL MA Inhibitor DMAU5WL RN Resistance of herpes simplex virus type 1 to peptidomimetic ribonucleotide reductase inhibitors: selection and characterization of mutant isolates. J Virol. 1996 Feb;70(2):787-93. DMAU5WL RU https://pubmed.ncbi.nlm.nih.gov/8551616 DM9X1DZ DI DM9X1DZ DM9X1DZ DN BIMG80 DM9X1DZ MI TTZFYLI DM9X1DZ MN Dopamine D1 receptor (D1R) DM9X1DZ MT DTT DM9X1DZ MA Modulator DM9X1DZ RN BIMG 80, a novel potential antipsychotic drug: evidence for multireceptor actions and preferential release of dopamine in prefrontal cortex. J Neurochem. 1997 Jul;69(1):182-90. DM9X1DZ RU https://pubmed.ncbi.nlm.nih.gov/9202309 DM9X1DZ DI DM9X1DZ DM9X1DZ DN BIMG80 DM9X1DZ MI TTEX248 DM9X1DZ MN Dopamine D2 receptor (D2R) DM9X1DZ MT DTT DM9X1DZ MA Modulator DM9X1DZ RN BIMG 80, a novel potential antipsychotic drug: evidence for multireceptor actions and preferential release of dopamine in prefrontal cortex. J Neurochem. 1997 Jul;69(1):182-90. DM9X1DZ RU https://pubmed.ncbi.nlm.nih.gov/9202309 DM9X1DZ DI DM9X1DZ DM9X1DZ DN BIMG80 DM9X1DZ MI TTE0A2F DM9X1DZ MN Dopamine D4 receptor (D4R) DM9X1DZ MT DTT DM9X1DZ MA Modulator DM9X1DZ RN BIMG 80, a novel potential antipsychotic drug: evidence for multireceptor actions and preferential release of dopamine in prefrontal cortex. J Neurochem. 1997 Jul;69(1):182-90. DM9X1DZ RU https://pubmed.ncbi.nlm.nih.gov/9202309 DMKNS10 DI DMKNS10 DMKNS10 DN BIPHALIN DMKNS10 MI TT27RFC DMKNS10 MN Opioid receptor delta (OPRD1) DMKNS10 MT DTT DMKNS10 MA Inhibitor DMKNS10 RN The biological activity and metabolic stability of peptidic bifunctional compounds that are opioid receptor agonists and neurokinin-1 receptor anta... Bioorg Med Chem. 2009 Oct 15;17(20):7337-43. DMKNS10 RU https://pubmed.ncbi.nlm.nih.gov/19762245 DMKNS10 DI DMKNS10 DMKNS10 DN BIPHALIN DMKNS10 MI TTKWM86 DMKNS10 MN Opioid receptor mu (MOP) DMKNS10 MT DTT DMKNS10 MA Inhibitor DMKNS10 RN Biological and conformational evaluation of bifunctional compounds for opioid receptor agonists and neurokinin 1 receptor antagonists possessing tw... J Med Chem. 2010 Aug 12;53(15):5491-501. DMKNS10 RU https://pubmed.ncbi.nlm.nih.gov/20617791 DMKRBL2 DI DMKRBL2 DMKRBL2 DN Bisbenzimide DMKRBL2 MI TTUTN1I DMKRBL2 MN Human Deoxyribonucleic acid (hDNA) DMKRBL2 MT DTT DMKRBL2 MA Binder (minor groove binder) DMKRBL2 RN Sequence-dependent effects in drug-DNA interaction: the crystal structure of Hoechst 33258 bound to the d(CGCAAATTTGCG)2 duplex. Nucleic Acids Res. 1994 May 11;22(9):1607-12. DMKRBL2 RU https://pubmed.ncbi.nlm.nih.gov/7515488 DMKRBL2 DI DMKRBL2 DMKRBL2 DN Bisbenzimide DMKRBL2 MI DTUGYRD DMKRBL2 MN P-glycoprotein 1 (ABCB1) DMKRBL2 MT DTP DMKRBL2 MA Substrate DMKRBL2 RN Mammalian drug efflux transporters of the ATP binding cassette (ABC) family in multidrug resistance: A review of the past decade. Cancer Lett. 2016 Jan 1;370(1):153-64. DMKRBL2 RU http://www.ncbi.nlm.nih.gov/pubmed/26499806 DM0DO4S DI DM0DO4S DM0DO4S DN Bivatuzumab mertansine DM0DO4S MI TTWFBT7 DM0DO4S MN Extracellular matrix receptor III (CD44) DM0DO4S MT DTT DM0DO4S RN A phase I dose escalation study with anti-CD44v6 bivatuzumab mertansine in patients with incurable squamous cell carcinoma of the head and neck or esophagus. Clin Cancer Res. 2006 Oct 15;12(20 Pt 1):6064-72. DM0DO4S RU https://pubmed.ncbi.nlm.nih.gov/17062682 DM9IQR6 DI DM9IQR6 DM9IQR6 DN BK-218 DM9IQR6 MI TTJP4SM DM9IQR6 MN Bacterial Penicillin binding protein (Bact PBP) DM9IQR6 MT DTT DM9IQR6 MA Inhibitor DM9IQR6 RN In vitro investigation of BK-218, a new oral and parenteral cephalosporin. Antimicrob Agents Chemother. 1990 Feb;34(2):349-54. DM9IQR6 RU https://pubmed.ncbi.nlm.nih.gov/2109582 DMGDTLX DI DMGDTLX DMGDTLX DN BL-1872 DMGDTLX MI TTMI6F5 DMGDTLX MN Transient receptor potential cation channel V1 (TRPV1) DMGDTLX MT DTT DMGDTLX MA Modulator DMGDTLX RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. DMGDTLX RU https://www.fda.gov/ DMKITQN DI DMKITQN DMKITQN DN BM-13677 DMKITQN MI TT3C1VN DMKITQN MN Enzyme unspecific (Enz) DMKITQN MT DTT DMKITQN MA Modulator DMKITQN RN Progress in medicinal chemistry, 1994. Page(448). DMKITQN RU https://books.google.com.hk/books?id=5_7mxy2G9a0C&pg=PA448&lpg=PA448&dq=%22BM-13677%22+enzyme&source=bl&ots=UzcIa2xi2D&sig=dx8ohd8OK-bXYWQUJ32VCTQc48A&hl=zh-CN&sa=X&ved=0CBoQ6AEwAGoVChMIn6Gx-cG_yAIVTyOOCh1w6Qe_#v=onepage&q=%22BM-13677%22%20enzyme&f=false DMWDRI0 DI DMWDRI0 DMWDRI0 DN BMS-180560 DMWDRI0 MI TTGN1ZA DMWDRI0 MN Angiotensin II receptor (AGTR) DMWDRI0 MT DTT DMWDRI0 MA Modulator DMWDRI0 RN BMS-180560, an insurmountable inhibitor of angiotensin II-stimulated responses: comparison with losartan and EXP3174. Br J Pharmacol. 1994 Sep;113(1):179-89. DMWDRI0 RU https://pubmed.ncbi.nlm.nih.gov/7812609 DM1Y75C DI DM1Y75C DM1Y75C DN BMS-181184 DM1Y75C MI TTXT4D5 DM1Y75C MN Bacterial Cell membrane (Bact CM) DM1Y75C MT DTT DM1Y75C MA Modulator DM1Y75C RN Antifungal Activity of the Pradimicin Derivative BMS 181184 in the Treatment of Experimental Pulmonary Aspergillosis in Persistently Neutropenic Rabbits. Antimicrob Agents Chemother. 1998 September; 42(9): 2399-2404. DM1Y75C RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC105840/ DMYWI04 DI DMYWI04 DMYWI04 DN BMS-181885 DMYWI04 MI TT6MSOK DMYWI04 MN 5-HT 1D receptor (HTR1D) DMYWI04 MT DTT DMYWI04 MA Agonist DMYWI04 RN Sensitive triple-quadrupole mass spectrometric assay for the determination of BMS-181885, a 5-HT1 agonist, in human plasma following solid phase extraction. Biomed Chromatogr. 1999 Oct;13(6):425-30. DMYWI04 RU https://pubmed.ncbi.nlm.nih.gov/10477901 DMEDLHG DI DMEDLHG DMEDLHG DN BMS-182193 DMEDLHG MI TT5FNQT DMEDLHG MN Human immunodeficiency virus Protease (HIV PR) DMEDLHG MT DTT DMEDLHG MA Modulator DMEDLHG RN Antiviral properties of aminodiol inhibitors against human immunodeficiency virus and protease. Antimicrob Agents Chemother. 1995 Feb;39(2):374-9. DMEDLHG RU https://pubmed.ncbi.nlm.nih.gov/7726501 DMO7C09 DI DMO7C09 DMO7C09 DN BMS-182566 DMO7C09 MI TT7WZIJ DMO7C09 MN CAAX farnesyltransferase beta (FNTB) DMO7C09 MT DTT DMO7C09 MA Modulator DMO7C09 RN US patent application no. 2005,0227,929, Combination therapy comprising a cox-2 inhibitor and an antineoplastic agent. DMO7C09 RU http://www.google.com/patents/US20050227929 DM0K4DZ DI DM0K4DZ DM0K4DZ DN BMS-182657 DM0K4DZ MI TTL69WB DM0K4DZ MN Angiotensin-converting enzyme (ACE) DM0K4DZ MT DTT DM0K4DZ MA Modulator DM0K4DZ RN Cardiovascular effects of the novel dual inhibitor of neutral endopeptidase and angiotensin-converting enzyme BMS-182657 in experimental hypertension and heart failure. J Pharmacol Exp Ther. 1995 Nov;275(2):745-52. DM0K4DZ RU https://pubmed.ncbi.nlm.nih.gov/7473162 DM0K4DZ DI DM0K4DZ DM0K4DZ DN BMS-182657 DM0K4DZ MI TT5TKPM DM0K4DZ MN Neutral endopeptidase (MME) DM0K4DZ MT DTT DM0K4DZ MA Modulator DM0K4DZ RN Cardiovascular effects of the novel dual inhibitor of neutral endopeptidase and angiotensin-converting enzyme BMS-182657 in experimental hypertension and heart failure. J Pharmacol Exp Ther. 1995 Nov;275(2):745-52. DM0K4DZ RU https://pubmed.ncbi.nlm.nih.gov/7473162 DM5PG6C DI DM5PG6C DM5PG6C DN BMS-182874 DM5PG6C MI TTKRD0G DM5PG6C MN Endothelin A receptor (EDNRA) DM5PG6C MT DTT DM5PG6C MA Inhibitor DM5PG6C RN Biphenylsulfonamide endothelin receptor antagonists. 2. Discovery of 4'-oxazolyl biphenylsulfonamides as a new class of potent, highly selective ET... J Med Chem. 2000 Aug 10;43(16):3111-7. DM5PG6C RU https://pubmed.ncbi.nlm.nih.gov/10956219 DMTA7O8 DI DMTA7O8 DMTA7O8 DN BMS-185857 DMTA7O8 MI TT7WZIJ DMTA7O8 MN CAAX farnesyltransferase beta (FNTB) DMTA7O8 MT DTT DMTA7O8 MA Modulator DMTA7O8 RN US patent application no. 2005,0227,929, Combination therapy comprising a cox-2 inhibitor and an antineoplastic agent. DMTA7O8 RU http://www.google.com/patents/US20050227929 DMKZ3PW DI DMKZ3PW DMKZ3PW DN BMS-186318 DMKZ3PW MI TT5FNQT DMKZ3PW MN Human immunodeficiency virus Protease (HIV PR) DMKZ3PW MT DTT DMKZ3PW MA Modulator DMKZ3PW RN Determination of BMS-186318 in dog, rat and monkey plasma by liquid chromatography-ionspray mass spectrometry. J Pharm Biomed Anal. 1995 Dec;14(1-2):43-8. DMKZ3PW RU https://pubmed.ncbi.nlm.nih.gov/8833965 DMV3B5Y DI DMV3B5Y DMV3B5Y DN BMS-189664 DMV3B5Y MI TT6L509 DMV3B5Y MN Coagulation factor IIa (F2) DMV3B5Y MT DTT DMV3B5Y MA Inhibitor DMV3B5Y RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015 DMV3B5Y RU https://www.accessdata.fda.gov/scripts/cder/drugsatfda/ DMMBTU6 DI DMMBTU6 DMMBTU6 DN BMS-210285 DMMBTU6 MI TTMXGCW DMMBTU6 MN Adrenergic receptor beta-3 (ADRB3) DMMBTU6 MT DTT DMMBTU6 MA Agonist DMMBTU6 RN CA patent application no. 509835, Nitrogen-containing heterocyclic derivatives, medicinal compositions containing the same and medicinal use thereof. DMMBTU6 RU https://www.google.com.ar/patents/CA2509835A1?cl=en DME20VP DI DME20VP DME20VP DN BMS-433771 DME20VP MI TT8DSFC DME20VP MN Hydroxyphenylpyruvate dioxygenase (HPD) DME20VP MT DTT DME20VP MA Inhibitor DME20VP RN Emerging drugs for respiratory syncytial virus infection. Expert Opin Emerg Drugs. 2009 Jun;14(2):207-17. DME20VP RU https://pubmed.ncbi.nlm.nih.gov/19453286 DMY7ZRA DI DMY7ZRA DMY7ZRA DN BMS-605339 DMY7ZRA MI TTWXB3E DMY7ZRA MN Hepatitis C virus NS3 helicase (HCV NS3) DMY7ZRA MT DTT DMY7ZRA MA Inhibitor DMY7ZRA RN Discovery and early clinical evaluation of BMS-605339, a potent and orally efficacious tripeptidic acylsulfonamide NS3 protease inhibitor for the treatment of hepatitis C virus infection. J Med Chem.2014 Mar 13;57(5):1708-29. DMY7ZRA RU https://pubmed.ncbi.nlm.nih.gov/24555570 DMDPJ8M DI DMDPJ8M DMDPJ8M DN BMY-20844 DMDPJ8M MI TT06AWU DMDPJ8M MN Phosphodiesterase 3A (PDE3A) DMDPJ8M MT DTT DMDPJ8M MA Inhibitor DMDPJ8M RN Inhibitors of blood platelet cAMP phosphodiesterase. 3. 1,3-Dihydro-2H-imidazo[4,5-b]quinolin-2-one derivatives with enhanced aqueous solubility. J Med Chem. 1992 Jul 10;35(14):2688-96. DMDPJ8M RU https://pubmed.ncbi.nlm.nih.gov/1321911 DMZFTLK DI DMZFTLK DMZFTLK DN BMY-22089 DMZFTLK MI TTPADOQ DMZFTLK MN HMG-CoA reductase (HMGCR) DMZFTLK MT DTT DMZFTLK MA Inhibitor DMZFTLK RN Selective inhibition of cholesterol synthesis in liver versus extrahepatic tissues by HMG-CoA reductase inhibitors. J Lipid Res. 1990 Jul;31(7):1271-82. DMZFTLK RU https://pubmed.ncbi.nlm.nih.gov/2401858 DM2TF9P DI DM2TF9P DM2TF9P DN BMY-40062 DM2TF9P MI TTN6J5F DM2TF9P MN Bacterial DNA gyrase (Bact gyrase) DM2TF9P MT DTT DM2TF9P MA Modulator DM2TF9P RN Relationships among antibacterial activity, inhibition of DNA gyrase, and intracellular accumulation of 11 fluoroquinolones. Antimicrob Agents Chemother. 1992 Dec;36(12):2622-7. DM2TF9P RU https://www.ncbi.nlm.nih.gov/pubmed/1336340 DM8R3N0 DI DM8R3N0 DM8R3N0 DN BMY-44621 DM8R3N0 MI TT2WR1T DM8R3N0 MN Cationic trypsinogen (PRSS1) DM8R3N0 MT DTT DM8R3N0 MA Inhibitor DM8R3N0 RN Design and synthesis of conformationally constrained arginal thrombin inhibitors, Bioorg. Med. Chem. Lett. 7(17):2205-2210 (1997). DM8R3N0 RU http://www.sciencedirect.com/science/article/pii/S0960894X97004034 DMRHCEG DI DMRHCEG DMRHCEG DN BMY-7378 DMRHCEG MI TTSQIFT DMRHCEG MN 5-HT 1A receptor (HTR1A) DMRHCEG MT DTT DMRHCEG MA Inhibitor DMRHCEG RN 8-[4-[2-(1,2,3,4-Tetrahydroisoquinolinyl]butyl-8-azaspiro[4.5]decane-7,9-dione: a new 5-HT1A receptor ligand with the same activity profile as busp... J Med Chem. 1996 Mar 1;39(5):1125-9. DMRHCEG RU https://pubmed.ncbi.nlm.nih.gov/8676348 DMRHCEG DI DMRHCEG DMRHCEG DN BMY-7378 DMRHCEG MI TTNGILX DMRHCEG MN Adrenergic receptor alpha-1A (ADRA1A) DMRHCEG MT DTT DMRHCEG MA Inhibitor DMRHCEG RN Synthesis and structure-activity relationship of fluoro analogues of 8-{2-[4-(4-methoxyphenyl)piperazin-1yl]ethyl}-8-azaspiro[4.5]decane-7,9-dione ... J Med Chem. 2005 Apr 21;48(8):3076-9. DMRHCEG RU https://pubmed.ncbi.nlm.nih.gov/15828846 DMRHCEG DI DMRHCEG DMRHCEG DN BMY-7378 DMRHCEG MI TTBRKXS DMRHCEG MN Adrenergic receptor alpha-1B (ADRA1B) DMRHCEG MT DTT DMRHCEG MA Inhibitor DMRHCEG RN Synthesis and structure-activity relationship of fluoro analogues of 8-{2-[4-(4-methoxyphenyl)piperazin-1yl]ethyl}-8-azaspiro[4.5]decane-7,9-dione ... J Med Chem. 2005 Apr 21;48(8):3076-9. DMRHCEG RU https://pubmed.ncbi.nlm.nih.gov/15828846 DMRHCEG DI DMRHCEG DMRHCEG DN BMY-7378 DMRHCEG MI TT34BHT DMRHCEG MN Adrenergic receptor alpha-1D (ADRA1D) DMRHCEG MT DTT DMRHCEG MA Inhibitor DMRHCEG RN Synthesis and structure-activity relationship of fluoro analogues of 8-{2-[4-(4-methoxyphenyl)piperazin-1yl]ethyl}-8-azaspiro[4.5]decane-7,9-dione ... J Med Chem. 2005 Apr 21;48(8):3076-9. DMRHCEG RU https://pubmed.ncbi.nlm.nih.gov/15828846 DMTKJDS DI DMTKJDS DMTKJDS DN BN-50726 DMTKJDS MI TTQL5VC DMTKJDS MN Platelet-activating factor receptor (PTAFR) DMTKJDS MT DTT DMTKJDS MA Antagonist DMTKJDS RN Effects of the PAF antagonists BN50726 and BN50739 on arrhythmogenesis and extent of necrosis during myocardial ischaemia/reperfusion in rabbits. Br J Pharmacol. 1992 Nov;107(3):705-9. DMTKJDS RU https://pubmed.ncbi.nlm.nih.gov/1472967 DMU1TRQ DI DMU1TRQ DMU1TRQ DN BN50739 DMU1TRQ MI TTQL5VC DMU1TRQ MN Platelet-activating factor receptor (PTAFR) DMU1TRQ MT DTT DMU1TRQ MA Modulator DMU1TRQ RN Effect of the platelet-activating factor antagonist BN 50739 and its diluents on mitochondrial respiration and membrane lipids during and following... J Neurochem. 1994 May;62(5):1929-38. DMU1TRQ RU https://www.ncbi.nlm.nih.gov/pubmed/8158141 DMMZ9DY DI DMMZ9DY DMMZ9DY DN BN-80245 DMMZ9DY MI TTGTQHC DMMZ9DY MN DNA topoisomerase I (TOP1) DMMZ9DY MT DTT DMMZ9DY MA Inhibitor DMMZ9DY RN BN 80245: An E-ring modified camptothecin with potent antiproliferative and topoisomerase I inhibitory activities. Bioorganic & Medicinal Chemistry Letters Volume 7, Issue 17, 9 September 1997, Pages2235-2238. DMMZ9DY RU http://www.sciencedirect.com/science/article/pii/S0960894X97003983 DMN8FAG DI DMN8FAG DMN8FAG DN BP4.879a DMN8FAG MI TTNXLKE DMN8FAG MN 5-HT 3 receptor (5HT3R) DMN8FAG MT DTT DMN8FAG MA Antagonist DMN8FAG RN 5-HT(3A) receptor subunit is required for 5-HT3 antagonist-induced reductions in alcohol drinking. Neuropsychopharmacology. 2004 Oct;29(10):1807-13. DMN8FAG RU https://pubmed.ncbi.nlm.nih.gov/15162158 DMN8FAG DI DMN8FAG DMN8FAG DN BP4.879a DMN8FAG MI TTPC4TU DMN8FAG MN 5-HT 3A receptor (HTR3A) DMN8FAG MT DTT DMN8FAG MA Antagonist DMN8FAG RN Pharmacological and regional characterization of [3H]LY278584 binding sites in human brain. J Neurochem. 1993 Feb;60(2):730-7. DMN8FAG RU https://pubmed.ncbi.nlm.nih.gov/8419547 DMN8FAG DI DMN8FAG DMN8FAG DN BP4.879a DMN8FAG MI TT4C8EA DMN8FAG MN Dopamine D3 receptor (D3R) DMN8FAG MT DTT DMN8FAG MA Antagonist DMN8FAG RN The pipeline and future of drug development in schizophrenia. Mol Psychiatry. 2007 Oct;12(10):904-22. DMN8FAG RU https://pubmed.ncbi.nlm.nih.gov/17667958 DM3O4BG DI DM3O4BG DM3O4BG DN BQ-518 DM3O4BG MI TTKRD0G DM3O4BG MN Endothelin A receptor (EDNRA) DM3O4BG MT DTT DM3O4BG MA Modulator DM3O4BG RN Structure-activity relationships of cyclic pentapeptide endothelin A receptor antagonists. J Med Chem. 1995 Oct 13;38(21):4309-24. DM3O4BG RU https://pubmed.ncbi.nlm.nih.gov/7473559 DMPRNQL DI DMPRNQL DMPRNQL DN BQ610 DMPRNQL MI TTKRD0G DMPRNQL MN Endothelin A receptor (EDNRA) DMPRNQL MT DTT DMPRNQL MA Antagonist DMPRNQL RN Human optic nerve head astrocytes as a target for endothelin-1. Invest Ophthalmol Vis Sci. 2002 Aug;43(8):2704-13. DMPRNQL RU https://pubmed.ncbi.nlm.nih.gov/12147606 DMGX0E1 DI DMGX0E1 DMGX0E1 DN BRL 26830A DMGX0E1 MI TTMXGCW DMGX0E1 MN Adrenergic receptor beta-3 (ADRB3) DMGX0E1 MT DTT DMGX0E1 MA Agonist DMGX0E1 RN Anti-obesity and anti-diabetic actions of a beta 3-adrenoceptor agonist, BRL 26830A, in yellow KK mice. Endocrinol Jpn. 1991 Aug;38(4):397-403. DMGX0E1 RU https://pubmed.ncbi.nlm.nih.gov/1687027 DMS4320 DI DMS4320 DMS4320 DN BRL 37344 DMS4320 MI TTMXGCW DMS4320 MN Adrenergic receptor beta-3 (ADRB3) DMS4320 MT DTT DMS4320 MA Agonist DMS4320 RN Effects of several putative beta 3-adrenoceptor agonists on lipolysis in human omental adipocytes. Int J Obes Relat Metab Disord. 1996 May;20(5):428-34. DMS4320 RU https://pubmed.ncbi.nlm.nih.gov/8696421 DMBC12X DI DMBC12X DMBC12X DN BRL-42715 DMBC12X MI TTHI19T DMBC12X MN Staphylococcus Beta-lactamase (Stap-coc blaZ) DMBC12X MT DTT DMBC12X MA Inhibitor DMBC12X RN In vitro evaluation of BRL 42715, a novel beta-lactamase inhibitor. Antimicrob Agents Chemother. 1989 Sep;33(9):1580-7. DMBC12X RU https://pubmed.ncbi.nlm.nih.gov/2817854 DMAH3Z9 DI DMAH3Z9 DMAH3Z9 DN BTS-79018 DMAH3Z9 MI TTSQIFT DMAH3Z9 MN 5-HT 1A receptor (HTR1A) DMAH3Z9 MT DTT DMAH3Z9 MA Binder DMAH3Z9 RN The pipeline and future of drug development in schizophrenia. Mol Psychiatry. 2007 Oct;12(10):904-22. DMAH3Z9 RU https://pubmed.ncbi.nlm.nih.gov/17667958 DMAH3Z9 DI DMAH3Z9 DMAH3Z9 DN BTS-79018 DMAH3Z9 MI TT4C8EA DMAH3Z9 MN Dopamine D3 receptor (D3R) DMAH3Z9 MT DTT DMAH3Z9 MA Binder DMAH3Z9 RN The pipeline and future of drug development in schizophrenia. Mol Psychiatry. 2007 Oct;12(10):904-22. DMAH3Z9 RU https://pubmed.ncbi.nlm.nih.gov/17667958 DMJDMTK DI DMJDMTK DMJDMTK DN BU-4514N DMJDMTK MI TTEDJN4 DMJDMTK MN Low-affinity nerve growth factor receptor (NGFR) DMJDMTK MT DTT DMJDMTK MA Modulator DMJDMTK RN A new neuritogenetic compound BU-4514N produced by Microtetraspora sp. J Antibiot (Tokyo). 1993 Jun;46(6):875-83. DMJDMTK RU https://pubmed.ncbi.nlm.nih.gov/8344867 DM4OT0S DI DM4OT0S DM4OT0S DN BU-4601A DM4OT0S MI TT2J34L DM4OT0S MN Arachidonate 5-lipoxygenase (5-LOX) DM4OT0S MT DTT DM4OT0S MA Inhibitor DM4OT0S RN 5-Hydroxyanthranilic acid derivatives as potent 5-lipoxygenase inhibitors. J Antibiot (Tokyo). 1993 May;46(5):705-11. DM4OT0S RU https://pubmed.ncbi.nlm.nih.gov/8514624 DMIYPLU DI DMIYPLU DMIYPLU DN BVT-142 DMIYPLU MI TTJ584C DMIYPLU MN Peroxisome proliferator-activated receptor alpha (PPARA) DMIYPLU MT DTT DMIYPLU MA Agonist DMIYPLU RN A new class of peroxisome proliferator-activated receptor agonists with a novel binding epitope shows antidiabetic effects. J Biol Chem. 2004 Sep 24;279(39):41124-30. DMIYPLU RU https://pubmed.ncbi.nlm.nih.gov/15258145 DMIYPLU DI DMIYPLU DMIYPLU DN BVT-142 DMIYPLU MI TTZMAO3 DMIYPLU MN Peroxisome proliferator-activated receptor gamma (PPAR-gamma) DMIYPLU MT DTT DMIYPLU MA Agonist DMIYPLU RN A new class of peroxisome proliferator-activated receptor agonists with a novel binding epitope shows antidiabetic effects. J Biol Chem. 2004 Sep 24;279(39):41124-30. DMIYPLU RU https://pubmed.ncbi.nlm.nih.gov/15258145 DMHLUFN DI DMHLUFN DMHLUFN DN BVT-24834 DMHLUFN MI TTMY6L1 DMHLUFN MN Fatty acid-binding protein (FABP) DMHLUFN MT DTT DMHLUFN MA Inhibitor DMHLUFN RN Fragment-Based Drug Discovery: A Practical Approach. Edward Zartler, Michael Shapiro, 2008. Page(84). DMHLUFN RU https://books.google.com.hk/books?id=9F9lZr6efAYC&pg=PA84&lpg=PA84&dq=%22BVT-1960%22++Fatty+acid&source=bl&ots=7Gqa3Stpb2&sig=jhrU7gjl54K0_vD7DwfrRUCfLpQ&hl=zh-CN&sa=X&ved=0CBoQ6AEwAGoVChMI0MaW3PzFyAIVFZCOCh1D2QNI#v=onepage&q=%22BVT-1960%22%20%20Fatty%20acid&f=false DMOZQHX DI DMOZQHX DMOZQHX DN BVT-3498 DMOZQHX MI TTN7BL9 DMOZQHX MN Corticosteroid 11-beta-dehydrogenase 1 (HSD11B1) DMOZQHX MT DTT DMOZQHX MA Inhibitor DMOZQHX RN Current and future drug targets in weight management. Pharm Res. 2011 Aug;28(8):1792-818. DMOZQHX RU https://pubmed.ncbi.nlm.nih.gov/21181547 DMXFZWJ DI DMXFZWJ DMXFZWJ DN BW 373U86 DMXFZWJ MI TT27RFC DMXFZWJ MN Opioid receptor delta (OPRD1) DMXFZWJ MT DTT DMXFZWJ MA Agonist DMXFZWJ RN BW373U86, a delta opioid agonist, partially mediates delayed cardioprotection via a free radical mechanism that is independent of opioid receptor stimulation. J Mol Cell Cardiol. 2001 Aug;33(8):1455-65. DMXFZWJ RU https://pubmed.ncbi.nlm.nih.gov/11448134 DMNUMDG DI DMNUMDG DMNUMDG DN BW A4C DMNUMDG MI TT2J34L DMNUMDG MN Arachidonate 5-lipoxygenase (5-LOX) DMNUMDG MT DTT DMNUMDG MA Inhibitor DMNUMDG RN Reactive oxygen species and lipoxygenases regulate the oncogenicity of NPM-ALK-positive anaplastic large cell lymphomas. Oncogene. 2009 Jul 23;28(29):2690-6. DMNUMDG RU https://pubmed.ncbi.nlm.nih.gov/19503098 DMNUMDG DI DMNUMDG DMNUMDG DN BW A4C DMNUMDG MI TTSJ6Q4 DMNUMDG MN LOX-5 messenger RNA (ALOX5 mRNA) DMNUMDG MT DTT DMNUMDG MA Inhibitor DMNUMDG RN Novel and potent inhibitors of 5-lipoxygenase product synthesis based on the structure of pirinixic acid. J Med Chem. 2008 Sep 11;51(17):5449-53. DMNUMDG RU https://pubmed.ncbi.nlm.nih.gov/18710209 DMTYCJ6 DI DMTYCJ6 DMTYCJ6 DN BW B70C DMTYCJ6 MI TT2J34L DMTYCJ6 MN Arachidonate 5-lipoxygenase (5-LOX) DMTYCJ6 MT DTT DMTYCJ6 MA Inhibitor DMTYCJ6 RN Hydroxamic acids and hydroxyureas as novel, selective 5-lipoxygenase inhibitors for possible use in asthma. Agents Actions Suppl. 1991;34:189-99. DMTYCJ6 RU https://pubmed.ncbi.nlm.nih.gov/1793063 DMEP9B6 DI DMEP9B6 DMEP9B6 DN BW-1003C87 DMEP9B6 MI TTRK8B9 DMEP9B6 MN Sodium channel unspecific (NaC) DMEP9B6 MT DTT DMEP9B6 MA Modulator DMEP9B6 RN The pyrimidine-derivative, BW1003C87, protects CA1 and striatal neurons following transient severe forebrain ischaemia in rats. A microdialysis and histological study. Neuroscience. 1993 Sep;56(1):93-9. DMEP9B6 RU https://pubmed.ncbi.nlm.nih.gov/7901808 DMQM3P4 DI DMQM3P4 DMQM3P4 DN BW755C DMQM3P4 MI TT2J34L DMQM3P4 MN Arachidonate 5-lipoxygenase (5-LOX) DMQM3P4 MT DTT DMQM3P4 MA Inhibitor DMQM3P4 RN Anti-inflammatory activity of Acanthus ilicifolius. J Ethnopharmacol. 2008 Oct 30;120(1):7-12. DMQM3P4 RU https://pubmed.ncbi.nlm.nih.gov/18703126 DMF6OY8 DI DMF6OY8 DMF6OY8 DN BW-A502U DMF6OY8 MI TTUTN1I DMF6OY8 MN Human Deoxyribonucleic acid (hDNA) DMF6OY8 MT DTT DMF6OY8 MA Binder DMF6OY8 RN Pharmacokinetics and disposition in the rat of a DNA intercalator 502U83. Drug Metab Dispos. 1993 Jan-Feb;21(1):62-70. DMF6OY8 RU https://pubmed.ncbi.nlm.nih.gov/8095228 DM0P8CE DI DM0P8CE DM0P8CE DN BX-044 DM0P8CE MI TT5QA2I DM0P8CE MN Plasminogen activator inhibitor (PAI) DM0P8CE MT DTT DM0P8CE MA Inhibitor DM0P8CE RN Characterization of a small molecule PAI-1 inhibitor, ZK4044. Thromb Res. 2005;115(4):341-50. DM0P8CE RU https://pubmed.ncbi.nlm.nih.gov/15668194 DMPL0C9 DI DMPL0C9 DMPL0C9 DN C-202 DMPL0C9 MI TTNJYV2 DMPL0C9 MN Gamma-aminobutyric acid receptor (GAR) DMPL0C9 MT DTT DMPL0C9 MA Modulator DMPL0C9 RN Capreomycin Binds across the Ribosomal Subunit Interface Using tlyA-Encoded 2 O-Methylations in 16S and 23S rRNAs. Molecular Cell Volume 23, Issue 2, 21 July 2006, Pages 173-182. DMPL0C9 RU http://www.sciencedirect.com/science/article/pii/S1097276506004333 DMJQ3WR DI DMJQ3WR DMJQ3WR DN C-AFG DMJQ3WR MI TT84ETX DMJQ3WR MN Human immunodeficiency virus Reverse transcriptase (HIV RT) DMJQ3WR MT DTT DMJQ3WR MA Modulator DMJQ3WR RN Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800003394) DMJQ3WR RU http://adisinsight.springer.com/drugs/800003394 DM9X2D0 DI DM9X2D0 DM9X2D0 DN Calphostin C DM9X2D0 MI DTUGYRD DM9X2D0 MN P-glycoprotein 1 (ABCB1) DM9X2D0 MT DTP DM9X2D0 MA Substrate DM9X2D0 RN Human intestinal transporter database: QSAR modeling and virtual profiling of drug uptake, efflux and interactions. Pharm Res. 2013 Apr;30(4):996-1007. DM9X2D0 RU https://doi.org/10.1007/s11095-012-0935-x DM9X2D0 DI DM9X2D0 DM9X2D0 DN Calphostin C DM9X2D0 MI TTYVX59 DM9X2D0 MN Protein kinase C (PRKC) DM9X2D0 MT DTT DM9X2D0 MA Inhibitor DM9X2D0 RN Protein kinase C zeta isoform is critical for proliferation in human glioblastoma cell lines. J Neurooncol. 2000 Apr;47(2):109-15. DM9X2D0 RU https://pubmed.ncbi.nlm.nih.gov/10982151 DMZ3QHF DI DMZ3QHF DMZ3QHF DN CB-102930 DMZ3QHF MI TTBZHDM DMZ3QHF MN Fungal Isoleucyl t-RNA synthetase (Fung ILS1) DMZ3QHF MT DTT DMZ3QHF MA Inhibitor DMZ3QHF RN Prospects for Aminoacyl-tRNA Synthetase Inhibitors as New Antimicrobial Agents. Antimicrob Agents Chemother. 2005 December; 49(12): 4821-4833. DMZ3QHF RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1315952/ DM75KBM DI DM75KBM DM75KBM DN CB-1267 DM75KBM MI TTK59TV DM75KBM MN Vitamin D3 receptor (VDR) DM75KBM MT DTT DM75KBM MA Modulator DM75KBM RN Novel 20-epi-vitamin D3 analog combined with 9-cis-retinoic acid markedly inhibits colony growth of prostate cancer cells. Prostate. 1999 Aug 1;40(3):141-9. DM75KBM RU https://pubmed.ncbi.nlm.nih.gov/10398275 DMJAGKY DI DMJAGKY DMJAGKY DN CBR-2092 DMJAGKY MI TTN6J5F DMJAGKY MN Bacterial DNA gyrase (Bact gyrase) DMJAGKY MT DTT DMJAGKY MA Modulator DMJAGKY RN In vitro evaluation of CBR-2092, a novel rifamycin-quinolone hybrid antibiotic: studies of the mode of action in Staphylococcus aureus.Antimicrob Agents Chemother.2008 Jul;52(7):2313-23. DMJAGKY RU https://www.ncbi.nlm.nih.gov/pubmed/18443108 DMJAGKY DI DMJAGKY DMJAGKY DN CBR-2092 DMJAGKY MI TTIXTO3 DMJAGKY MN Staphylococcus Topoisomerase IV (Stap-coc parC) DMJAGKY MT DTT DMJAGKY MA Modulator DMJAGKY RN In vitro evaluation of CBR-2092, a novel rifamycin-quinolone hybrid antibiotic: studies of the mode of action in Staphylococcus aureus.Antimicrob Agents Chemother.2008 Jul;52(7):2313-23. DMJAGKY RU https://www.ncbi.nlm.nih.gov/pubmed/18443108 DMAZB1R DI DMAZB1R DMAZB1R DN CCR5Qb DMAZB1R MI TT2CEJG DMAZB1R MN C-C chemokine receptor type 5 (CCR5) DMAZB1R MT DTT DMAZB1R RN Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800021743) DMAZB1R RU http://adisinsight.springer.com/drugs/800021743 DM5FEBQ DI DM5FEBQ DM5FEBQ DN CD-832 DM5FEBQ MI TT5HONZ DM5FEBQ MN Calcium channel unspecific (CaC) DM5FEBQ MT DTT DM5FEBQ MA Modulator DM5FEBQ RN Effects of CD-832, a new calcium antagonist, on intracranial pressure in anesthetized dogs. Life Sci. 1998;62(19):PL283-8. DM5FEBQ RU https://pubmed.ncbi.nlm.nih.gov/9585114 DMGQ9WP DI DMGQ9WP DMGQ9WP DN CDE-5110 DMGQ9WP MI TTZN7RP DMGQ9WP MN Rho-associated protein kinase 1 (ROCK1) DMGQ9WP MT DTT DMGQ9WP MA Inhibitor DMGQ9WP RN Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800025959) DMGQ9WP RU http://adisinsight.springer.com/drugs/800025959 DMGQ9WP DI DMGQ9WP DMGQ9WP DN CDE-5110 DMGQ9WP MI TTGWKQJ DMGQ9WP MN Rho-associated protein kinase 2 (ROCK2) DMGQ9WP MT DTT DMGQ9WP MA Inhibitor DMGQ9WP RN Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800025959) DMGQ9WP RU http://adisinsight.springer.com/drugs/800025959 DMVHTQI DI DMVHTQI DMVHTQI DN CDE-5498 DMVHTQI MI TTPLQO0 DMVHTQI MN Voltage-gated potassium channel Kv4.3 (KCND3) DMVHTQI MT DTT DMVHTQI MA Antagonist DMVHTQI RN Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800020444) DMVHTQI RU http://adisinsight.springer.com/drugs/800020444 DMA0DKI DI DMA0DKI DMA0DKI DN CDE-6960 DMA0DKI MI TTBZ7OD DMA0DKI MN Protein kinase C epsilon (PRKCE) DMA0DKI MT DTT DMA0DKI MA Inhibitor DMA0DKI RN Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800025002) DMA0DKI RU http://adisinsight.springer.com/drugs/800025002 DMA0DKI DI DMA0DKI DMA0DKI DN CDE-6960 DMA0DKI MI TT8QL1J DMA0DKI MN Protein kinase C theta (PRKCQ) DMA0DKI MT DTT DMA0DKI MA Inhibitor DMA0DKI RN Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800025002) DMA0DKI RU http://adisinsight.springer.com/drugs/800025002 DMGMS2D DI DMGMS2D DMGMS2D DN CDP-845 DMGMS2D MI TTLM12X DMGMS2D MN Matrix metalloproteinase-2 (MMP-2) DMGMS2D MT DTT DMGMS2D MA Modulator DMGMS2D RN Clinical potential of matrix metalloprotease inhibitors. Drugs R D. 1999 Feb;1(2):117-29. DMGMS2D RU https://pubmed.ncbi.nlm.nih.gov/10566004 DMGMS2D DI DMGMS2D DMGMS2D DN CDP-845 DMGMS2D MI TT6X50U DMGMS2D MN Matrix metalloproteinase-9 (MMP-9) DMGMS2D MT DTT DMGMS2D MA Modulator DMGMS2D RN Clinical potential of matrix metalloprotease inhibitors. Drugs R D. 1999 Feb;1(2):117-29. DMGMS2D RU https://pubmed.ncbi.nlm.nih.gov/10566004 DMNJXRG DI DMNJXRG DMNJXRG DN CEB-925 DMNJXRG MI TTMF541 DMNJXRG MN Liver carboxylesterase (CES1) DMNJXRG MT DTT DMNJXRG MA Inhibitor DMNJXRG RN Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800010079) DMNJXRG RU http://adisinsight.springer.com/drugs/800010079 DMGEFX7 DI DMGEFX7 DMGEFX7 DN CEE-03-320 DMGEFX7 MI TTZFYLI DMGEFX7 MN Dopamine D1 receptor (D1R) DMGEFX7 MT DTT DMGEFX7 MA Modulator DMGEFX7 RN Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800007189) DMGEFX7 RU http://adisinsight.springer.com/drugs/800007189 DMZE0SJ DI DMZE0SJ DMZE0SJ DN CEP-4186 DMZE0SJ MI TTK59TV DMZE0SJ MN Vitamin D3 receptor (VDR) DMZE0SJ MT DTT DMZE0SJ MA Modulator DMZE0SJ RN Novel vitamin D3 analog (CB1093) when combined with paclitaxel and cisplatin inhibit growth of MCF-7 human breast cancer cells in vivo. Int J Oncol. 1998 Sep;13(3):421-8. DMZE0SJ RU https://pubmed.ncbi.nlm.nih.gov/9683773 DMTI10C DI DMTI10C DMTI10C DN CEP-427 DMTI10C MI TTEDJN4 DMTI10C MN Low-affinity nerve growth factor receptor (NGFR) DMTI10C MT DTT DMTI10C MA Modulator DMTI10C RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1888). DMTI10C RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1888 DMDH0AM DI DMDH0AM DMDH0AM DN CEP-431 DMDH0AM MI TTZBFA0 DMDH0AM MN Protease unspecific (PRO) DMDH0AM MT DTT DMDH0AM MA Inhibitor DMDH0AM RN US patent application no. 7,935,815, Imidazoyl pyridine compounds and salts thereof. DMDH0AM RU http://www.google.com/patents/US7935815 DMFRW0G DI DMFRW0G DMFRW0G DN CEP-5214 DMFRW0G MI TTUTJGQ DMFRW0G MN Vascular endothelial growth factor receptor 2 (KDR) DMFRW0G MT DTT DMFRW0G MA Antagonist DMFRW0G RN Neuropilin-2 interacts with VEGFR-2 and VEGFR-3 and promotes human endothelial cell survival and migration. Blood. 2006 Aug 15;108(4):1243-50. DMFRW0G RU https://pubmed.ncbi.nlm.nih.gov/16621967 DM956N7 DI DM956N7 DM956N7 DN CEP-751 DM956N7 MI TT4DXQT DM956N7 MN Proto-oncogene c-Ret (RET) DM956N7 MT DTT DM956N7 MA Inhibitor DM956N7 RN CEP-701 and CEP-751 inhibit constitutively activated RET tyrosine kinase activity and block medullary thyroid carcinoma cell growth. Cancer Res. 2003 Sep 1;63(17):5559-63. DM956N7 RU https://pubmed.ncbi.nlm.nih.gov/14500395 DMIDFLV DI DMIDFLV DMIDFLV DN Cetamolol DMIDFLV MI TTR6W5O DMIDFLV MN Adrenergic receptor beta-1 (ADRB1) DMIDFLV MT DTT DMIDFLV MA Modulator DMIDFLV RN Comparison of the beta-adrenoceptor affinity and selectivity of cetamolol, atenolol, betaxolol, and ICI-118,551. J Cardiovasc Pharmacol. 1988 Aug;12(2):208-17. DMIDFLV RU https://pubmed.ncbi.nlm.nih.gov/2459552 DM5ESZU DI DM5ESZU DM5ESZU DN CGP-25454A DM5ESZU MI TTEX248 DM5ESZU MN Dopamine D2 receptor (D2R) DM5ESZU MT DTT DM5ESZU MA Modulator DM5ESZU RN CGP 25454A, a novel and selective presynaptic dopamine autoreceptor antagonist. Naunyn Schmiedebergs Arch Pharmacol. 1994 Sep;350(3):230-8. DM5ESZU RU https://pubmed.ncbi.nlm.nih.gov/7824038 DMZM70X DI DMZM70X DMZM70X DN CGP-35348 DMZM70X MI TTDCVZW DMZM70X MN Gamma-aminobutyric acid B receptor (GABBR) DMZM70X MT DTT DMZM70X MA Modulator DMZM70X RN The selective GABAB antagonist CGP-35348 blocks spike-wave bursts in the cholesterol synthesis rat absence epilepsy model. Brain Res. 1996 Aug 12;729(2):147-50. DMZM70X RU https://www.ncbi.nlm.nih.gov/pubmed/8876982 DM69YWS DI DM69YWS DM69YWS DN CGP-40215A DM69YWS MI TTBFROQ DM69YWS MN S-adenosylmethionine decarboxylase proenzyme (AMD1) DM69YWS MT DTT DM69YWS MA Modulator DM69YWS RN Antileishmanial effect of a potent S-adenosylmethionine decarboxylase inhibitor: CGP 40215A. Pharmacol Res. 1996 Jan;33(1):67-70. DM69YWS RU https://pubmed.ncbi.nlm.nih.gov/8817649 DMIWUFC DI DMIWUFC DMIWUFC DN CGP-52411 DMIWUFC MI TTGKNB4 DMIWUFC MN Epidermal growth factor receptor (EGFR) DMIWUFC MT DTT DMIWUFC MA Inhibitor DMIWUFC RN Retinoic acid-induced RB (retinoblastoma) hypophosphorylation enhanced by CGP 52411 (4,5-dianilinophthalimide), an EGF family tyrosine kinase receptor inhibitor. Eur J Cell Biol. 1996 Apr;69(4):327-34. DMIWUFC RU https://pubmed.ncbi.nlm.nih.gov/8741214 DM9VDZP DI DM9VDZP DM9VDZP DN CGP-53353 DM9VDZP MI TTGKNB4 DM9VDZP MN Epidermal growth factor receptor (EGFR) DM9VDZP MT DTT DM9VDZP MA Inhibitor DM9VDZP RN Dianilinophthalimides: potent and selective, ATP-competitive inhibitors of the EGF-receptor protein tyrosine kinase. J Med Chem. 1994 Apr 1;37(7):1015-27. DM9VDZP RU https://pubmed.ncbi.nlm.nih.gov/8151612 DMJ325M DI DMJ325M DMJ325M DN CGP-53716 DMJ325M MI TTI2WET DMJ325M MN Platelet-derived growth factor receptor (PDGFR) DMJ325M MT DTT DMJ325M MA Modulator DMJ325M RN Inhibition of cell growth: effects of the tyrosine kinase inhibitor CGP 53716. J Pharmacol Exp Ther. 1997 Oct;283(1):402-10. DMJ325M RU https://pubmed.ncbi.nlm.nih.gov/9336349 DM4TGY0 DI DM4TGY0 DM4TGY0 DN CGP-60474 DM4TGY0 MI TTH6V3D DM4TGY0 MN Cyclin-dependent kinase 1 (CDK1) DM4TGY0 MT DTT DM4TGY0 MA Inhibitor DM4TGY0 RN Synthesis and discovery of pyrazine-pyridine biheteroaryl as a novel series of potent vascular endothelial growth factor receptor-2 inhibitors. J Med Chem. 2005 Mar 24;48(6):1886-900. DM4TGY0 RU https://pubmed.ncbi.nlm.nih.gov/15771433 DMRLXC3 DI DMRLXC3 DMRLXC3 DN CGP-70726 DMRLXC3 MI TT5FNQT DMRLXC3 MN Human immunodeficiency virus Protease (HIV PR) DMRLXC3 MT DTT DMRLXC3 MA Modulator DMRLXC3 RN Oral bioavailability of a poorly water soluble HIV-1 protease inhibitor incorporated into pH-sensitive particles: effect of the particle size and nutritional state. J Control Release. 2000 Aug 10;68(2):291-8. DMRLXC3 RU https://pubmed.ncbi.nlm.nih.gov/10925137 DMKUETX DI DMKUETX DMKUETX DN CGS 8515 DMKUETX MI TT2J34L DMKUETX MN Arachidonate 5-lipoxygenase (5-LOX) DMKUETX MT DTT DMKUETX MA Inhibitor DMKUETX RN Characterization of CGS 8515 as a selective 5-lipoxygenase inhibitor using in vitro and in vivo models. Biochim Biophys Acta. 1988 Apr 15;959(3):332-42. DMKUETX RU https://pubmed.ncbi.nlm.nih.gov/2833314 DM6MEX4 DI DM6MEX4 DM6MEX4 DN CGS-12066B DM6MEX4 MI TTK8CXU DM6MEX4 MN 5-HT 1B receptor (HTR1B) DM6MEX4 MT DTT DM6MEX4 MA Modulator DM6MEX4 RN Biochemical and pharmacological characterization of CGS 12066B, a selective serotonin-1B agonist. Eur J Pharmacol. 1987 Apr 7;136(1):1-9. DM6MEX4 RU https://www.ncbi.nlm.nih.gov/pubmed/3496228 DMUPKYO DI DMUPKYO DMUPKYO DN CGS-13080 DMUPKYO MI TTKNWZ4 DMUPKYO MN Thromboxane-A synthase (TBXAS1) DMUPKYO MT DTT DMUPKYO MA Inhibitor DMUPKYO RN Imidazo[1,5-a]pyridines: a new class of thromboxane A2 synthetase inhibitors. J Med Chem. 1985 Feb;28(2):164-70. DMUPKYO RU https://pubmed.ncbi.nlm.nih.gov/3918169 DMMZJY3 DI DMMZJY3 DMMZJY3 DN CGS-17867A DMMZJY3 MI TTBMV1G DMMZJY3 MN GABA(A) receptor alpha-2 (GABRA2) DMMZJY3 MT DTT DMMZJY3 MA Inhibitor DMMZJY3 RN 2,5-Dihydropyrazolo[4,3-c]pyridin-3-ones: functionally selective benzodiazepine binding site ligands on the GABAA receptor. Bioorg Med Chem Lett. 2004 Jul 5;14(13):3441-4. DMMZJY3 RU https://pubmed.ncbi.nlm.nih.gov/15177449 DMMZJY3 DI DMMZJY3 DMMZJY3 DN CGS-17867A DMMZJY3 MI TT06RH5 DMMZJY3 MN GABA(A) receptor gamma-2 (GABRG2) DMMZJY3 MT DTT DMMZJY3 MA Inhibitor DMMZJY3 RN 2,5-Dihydropyrazolo[4,3-c]pyridin-3-ones: functionally selective benzodiazepine binding site ligands on the GABAA receptor. Bioorg Med Chem Lett. 2004 Jul 5;14(13):3441-4. DMMZJY3 RU https://pubmed.ncbi.nlm.nih.gov/15177449 DMMZJY3 DI DMMZJY3 DMMZJY3 DN CGS-17867A DMMZJY3 MI TTNJYV2 DMMZJY3 MN Gamma-aminobutyric acid receptor (GAR) DMMZJY3 MT DTT DMMZJY3 MA Inhibitor DMMZJY3 RN 2,5-Dihydropyrazolo[4,3-c]pyridin-3-ones: functionally selective benzodiazepine binding site ligands on the GABAA receptor. Bioorg Med Chem Lett. 2004 Jul 5;14(13):3441-4. DMMZJY3 RU https://pubmed.ncbi.nlm.nih.gov/15177449 DM4W3MU DI DM4W3MU DM4W3MU DN CGS-18102A DM4W3MU MI TTSQIFT DM4W3MU MN 5-HT 1A receptor (HTR1A) DM4W3MU MT DTT DM4W3MU MA Modulator DM4W3MU RN Quantitative determination of CGS 18102A, a new anxiolytic, in human plasma using capillary gas chromatography/mass spectrometry. Biomed Chromatogr. 1992 Sep-Oct;6(5):244-7. DM4W3MU RU https://pubmed.ncbi.nlm.nih.gov/1361157 DMFZM09 DI DMFZM09 DMFZM09 DN CGS-26303 DMFZM09 MI TT5TKPM DMFZM09 MN Neutral endopeptidase (MME) DMFZM09 MT DTT DMFZM09 MA Inhibitor DMFZM09 RN Potent non-peptidic dual inhibitors of endothelin-converting enzyme and neutral endopeptidase 24.11, Bioorg. Med. Chem. Lett. 7(8):1059-1064 (1997). DMFZM09 RU http://www.sciencedirect.com/science/article/pii/S0960894X97001595 DM4U72A DI DM4U72A DM4U72A DN CGS-26393 DM4U72A MI TT5TKPM DM4U72A MN Neutral endopeptidase (MME) DM4U72A MT DTT DM4U72A MA Modulator DM4U72A RN Oral administration of an inhibitor of endothelin-converting enzyme attenuates cerebral vasospasm following experimental subarachnoid haemorrhage in rabbits. Clin Sci (Lond). 2002 Aug;103 Suppl 48:414S-417S. DM4U72A RU https://pubmed.ncbi.nlm.nih.gov/12193135 DMJ4FGZ DI DMJ4FGZ DMJ4FGZ DN CGS-26529 DMJ4FGZ MI TT2J34L DMJ4FGZ MN Arachidonate 5-lipoxygenase (5-LOX) DMJ4FGZ MT DTT DMJ4FGZ MA Inhibitor DMJ4FGZ RN CGS 26529: the biological profile of a novel, orally active 5-lipoxygenase inhibitor with an extended duration of action. Inflamm Res. 1995 Aug;44 Suppl 2:S147-8. DMJ4FGZ RU https://pubmed.ncbi.nlm.nih.gov/8548371 DM8TLY3 DI DM8TLY3 DM8TLY3 DN CGS-27830 DM8TLY3 MI TTZIFHC DM8TLY3 MN Voltage-gated calcium channel alpha Cav1.2 (CACNA1C) DM8TLY3 MT DTT DM8TLY3 MA Inhibitor DM8TLY3 RN CGS 27830, a potent nonpeptide endothelin receptor antagonist, Bioorg. Med. Chem. Lett. 3(10):2099-2104 (1993). DM8TLY3 RU http://www.sciencedirect.com/science/article/pii/S0960894X01810258 DM8TLY3 DI DM8TLY3 DM8TLY3 DN CGS-27830 DM8TLY3 MI TT7RGTM DM8TLY3 MN Voltage-gated calcium channel alpha Cav1.3 (CACNA1D) DM8TLY3 MT DTT DM8TLY3 MA Inhibitor DM8TLY3 RN CGS 27830, a potent nonpeptide endothelin receptor antagonist, Bioorg. Med. Chem. Lett. 3(10):2099-2104 (1993). DM8TLY3 RU http://www.sciencedirect.com/science/article/pii/S0960894X01810258 DM94WIO DI DM94WIO DM94WIO DN CGS-30440 DM94WIO MI TTL69WB DM94WIO MN Angiotensin-converting enzyme (ACE) DM94WIO MT DTT DM94WIO MA Modulator DM94WIO RN Antihypertensive and natriuretic effects of CGS 30440, a dual inhibitor of angiotensin-converting enzyme and neutral endopeptidase 24.11. J Pharmacol Exp Ther. 1998 Mar;284(3):974-82. DM94WIO RU https://pubmed.ncbi.nlm.nih.gov/9495857 DM94WIO DI DM94WIO DM94WIO DN CGS-30440 DM94WIO MI TT5TKPM DM94WIO MN Neutral endopeptidase (MME) DM94WIO MT DTT DM94WIO MA Modulator DM94WIO RN Antihypertensive and natriuretic effects of CGS 30440, a dual inhibitor of angiotensin-converting enzyme and neutral endopeptidase 24.11. J Pharmacol Exp Ther. 1998 Mar;284(3):974-82. DM94WIO RU https://pubmed.ncbi.nlm.nih.gov/9495857 DM1VZ2I DI DM1VZ2I DM1VZ2I DN CGS-32359 DM1VZ2I MI TTKANGO DM1VZ2I MN Complement C5 (CO5) DM1VZ2I MT DTT DM1VZ2I MA Inhibitor DM1VZ2I RN Anticomplement therapy. Biologics. 2008 December; 2(4): 671-685. DM1VZ2I RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2727911/ DM39PQI DI DM39PQI DM39PQI DN CGS-9896 DM39PQI MI TT1MPAY DM39PQI MN GABA(A) receptor alpha-1 (GABRA1) DM39PQI MT DTT DM39PQI MA Inhibitor DM39PQI RN Synthesis, pharmacology, and structure-activity relationships of novel imidazolones and pyrrolones as modulators of GABAA receptors. J Med Chem. 2006 Mar 23;49(6):1855-66. DM39PQI RU https://pubmed.ncbi.nlm.nih.gov/16539371 DM39PQI DI DM39PQI DM39PQI DN CGS-9896 DM39PQI MI TTZA1NY DM39PQI MN GABA(A) receptor beta-2 (GABRB2) DM39PQI MT DTT DM39PQI MA Inhibitor DM39PQI RN Synthesis, pharmacology, and structure-activity relationships of novel imidazolones and pyrrolones as modulators of GABAA receptors. J Med Chem. 2006 Mar 23;49(6):1855-66. DM39PQI RU https://pubmed.ncbi.nlm.nih.gov/16539371 DM39PQI DI DM39PQI DM39PQI DN CGS-9896 DM39PQI MI TT06RH5 DM39PQI MN GABA(A) receptor gamma-2 (GABRG2) DM39PQI MT DTT DM39PQI MA Inhibitor DM39PQI RN Synthesis, pharmacology, and structure-activity relationships of novel imidazolones and pyrrolones as modulators of GABAA receptors. J Med Chem. 2006 Mar 23;49(6):1855-66. DM39PQI RU https://pubmed.ncbi.nlm.nih.gov/16539371 DM39PQI DI DM39PQI DM39PQI DN CGS-9896 DM39PQI MI TTNJYV2 DM39PQI MN Gamma-aminobutyric acid receptor (GAR) DM39PQI MT DTT DM39PQI MA Inhibitor DM39PQI RN Synthesis, pharmacology, and structure-activity relationships of novel imidazolones and pyrrolones as modulators of GABAA receptors. J Med Chem. 2006 Mar 23;49(6):1855-66. DM39PQI RU https://pubmed.ncbi.nlm.nih.gov/16539371 DMADYF7 DI DMADYF7 DMADYF7 DN CGX-1160 DMADYF7 MI TTTUMEP DMADYF7 MN Neurotensin receptor type 1 (NTSR1) DMADYF7 MT DTT DMADYF7 MA Agonist DMADYF7 RN Clinical status of anti-cancer agents derived from marine sources. Anticancer Agents Med Chem. 2008 Aug;8(6):603-17. DMADYF7 RU https://pubmed.ncbi.nlm.nih.gov/18690825 DMJ2P1Q DI DMJ2P1Q DMJ2P1Q DN CI-1002 DMJ2P1Q MI TT1RS9F DMJ2P1Q MN Acetylcholinesterase (AChE) DMJ2P1Q MT DTT DMJ2P1Q MA Modulator DMJ2P1Q RN PD 142676 (CI 1002), a novel anticholinesterase and muscarinic antagonist. Mol Neurobiol. 1994 Aug-Dec;9(1-3):93-106. DMJ2P1Q RU https://pubmed.ncbi.nlm.nih.gov/7888109 DMUK9L4 DI DMUK9L4 DMUK9L4 DN CI-1021 DMUK9L4 MI TTZPO1L DMUK9L4 MN Substance-P receptor (TACR1) DMUK9L4 MT DTT DMUK9L4 MA Antagonist DMUK9L4 RN Gabapentin and the neurokinin(1) receptor antagonist CI-1021 act synergistically in two rat models of neuropathic pain. J Pharmacol Exp Ther. 2002 Nov;303(2):730-5. DMUK9L4 RU https://pubmed.ncbi.nlm.nih.gov/12388658 DMI0TD8 DI DMI0TD8 DMI0TD8 DN CI-986 DMI0TD8 MI TT2J34L DMI0TD8 MN Arachidonate 5-lipoxygenase (5-LOX) DMI0TD8 MT DTT DMI0TD8 MA Modulator DMI0TD8 RN Role of leukotrienes on coronary vasoconstriction in isolated hearts of arthritic rats: effect of in vivo treatment with CI-986, a dual inhibitor of cyclooxygenase and lipoxygenase. Pharmacology. 2000 Jan;60(1):41-6. DMI0TD8 RU https://pubmed.ncbi.nlm.nih.gov/10629442 DMBHYIJ DI DMBHYIJ DMBHYIJ DN CI-992 DMBHYIJ MI TTPT2QI DMBHYIJ MN Cathepsin D (CTSD) DMBHYIJ MT DTT DMBHYIJ MA Inhibitor DMBHYIJ RN Structure-activity relationships of a series of 2-amino-4-thiazole-containing renin inhibitors. J Med Chem. 1992 Jul 10;35(14):2562-72. DMBHYIJ RU https://pubmed.ncbi.nlm.nih.gov/1635057 DMCJ7N1 DI DMCJ7N1 DMCJ7N1 DN CI-996 DMCJ7N1 MI TTGN1ZA DMCJ7N1 MN Angiotensin II receptor (AGTR) DMCJ7N1 MT DTT DMCJ7N1 MA Modulator DMCJ7N1 RN Pharmacologic characterization of CI-996, a new angiotensin receptor antagonist. J Pharmacol Exp Ther. 1995 Mar;272(3):963-9. DMCJ7N1 RU https://pubmed.ncbi.nlm.nih.gov/7891350 DMV1J0P DI DMV1J0P DMV1J0P DN CI-999 DMV1J0P MI TTMF541 DMV1J0P MN Liver carboxylesterase (CES1) DMV1J0P MT DTT DMV1J0P MA Inhibitor DMV1J0P RN Inhibitors of acyl-CoA:cholesterol O-acyltransferase (ACAT) as hypocholesterolemic agents: synthesis and structure-activity relationships of novel series of sulfonamides, acylphosphonamides and acylphosphoramidates. Bioorg Med Chem Lett. 1998 Feb 3;8(3):289-94. DMV1J0P RU https://pubmed.ncbi.nlm.nih.gov/9871672 DMBNWM1 DI DMBNWM1 DMBNWM1 DN Cilofungin DMBNWM1 MI TTZMS1L DMBNWM1 MN Fungal Papulacandin B resistance protein 1 (Fung FKS1) DMBNWM1 MT DTT DMBNWM1 MA Inhibitor DMBNWM1 RN Cryptococcus neoformans resistance to echinocandins: (1,3)beta-glucan synthase activity is sensitive to echinocandins. Antimicrob Agents Chemother. 2005 Jul;49(7):2851-6. DMBNWM1 RU https://pubmed.ncbi.nlm.nih.gov/15980360 DM0NJMG DI DM0NJMG DM0NJMG DN Ciprokiren DM0NJMG MI TTB2MXP DM0NJMG MN Angiotensinogenase renin (REN) DM0NJMG MT DTT DM0NJMG MA Inhibitor DM0NJMG RN Ciprokiren (Ro 44-9375). A renin inhibitor with increasing effects on chronic treatment. Hypertension. 1994 Aug;24(2):163-9. DM0NJMG RU https://pubmed.ncbi.nlm.nih.gov/8039839 DMJBGI1 DI DMJBGI1 DMJBGI1 DN CL-184005 DMJBGI1 MI TTQL5VC DMJBGI1 MN Platelet-activating factor receptor (PTAFR) DMJBGI1 MT DTT DMJBGI1 MA Modulator DMJBGI1 RN Studies of the effect of a platelet-activating factor antagonist, CL 184,005, in animal models of gram-negative bacterial sepsis. Antimicrob Agents Chemother. 1992 Sep;36(9):1971-7. DMJBGI1 RU https://www.ncbi.nlm.nih.gov/pubmed/1416889 DMYML2N DI DMYML2N DMYML2N DN CL-186659 DMYML2N MI TTHI19T DMYML2N MN Staphylococcus Beta-lactamase (Stap-coc blaZ) DMYML2N MT DTT DMYML2N MA Modulator DMYML2N RN US patent application no. 2004,0023,290, Novel therapeutic agents that modulate enzymatic processes. DMYML2N RU http://www.google.com/patents/US20040023290 DMA4DNX DI DMA4DNX DMA4DNX DN CL-387626 DMA4DNX MI TT57ID8 DMA4DNX MN Respiratory syncytial virus protein F (RSV F) DMA4DNX MT DTT DMA4DNX MA Inhibitor DMA4DNX RN Respiratory Syncytial Virus Entry Inhibitors Targeting the F Protein. Viruses. 2013 January; 5(1): 211-225. DMA4DNX RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3564118/ DM8TQC9 DI DM8TQC9 DM8TQC9 DN Clentiazem DM8TQC9 MI TT5HONZ DM8TQC9 MN Calcium channel unspecific (CaC) DM8TQC9 MT DTT DM8TQC9 MA Modulator DM8TQC9 RN Coronary and cardiac sensitivity to the vasoselective benzothiazepine-like calcium antagonist, clentiazem, in experimental heart failure. Cardiovasc Drugs Ther. 1997 Mar;11(1):71-9. DM8TQC9 RU https://www.ncbi.nlm.nih.gov/pubmed/9140681 DM6F8L5 DI DM6F8L5 DM6F8L5 DN Clinafloxacin DM6F8L5 MI TTN6J5F DM6F8L5 MN Bacterial DNA gyrase (Bact gyrase) DM6F8L5 MT DTT DM6F8L5 MA Modulator DM6F8L5 RN DNA gyrase and topoisomerase IV are dual targets of clinafloxacin action in Streptococcus pneumoniae. Antimicrob Agents Chemother. 1998 Nov;42(11):2810-6. DM6F8L5 RU https://pubmed.ncbi.nlm.nih.gov/9797208 DMVUL4P DI DMVUL4P DMVUL4P DN CLX-0301 DMVUL4P MI TTJSQEF DMVUL4P MN Tyrosine-protein kinase (PTK) DMVUL4P MT DTT DMVUL4P MA Inhibitor DMVUL4P RN CLX-0901 (Calyx Therapeutics). Curr Opin Investig Drugs. 2001 May;2(5):650-3. DMVUL4P RU https://pubmed.ncbi.nlm.nih.gov/11569941 DMYPRS9 DI DMYPRS9 DMYPRS9 DN CLX-0900 DMYPRS9 MI TTCBFJO DMYPRS9 MN Insulin receptor (INSR) DMYPRS9 MT DTT DMYPRS9 MA Modulator DMYPRS9 RN CLX-0901 (Calyx Therapeutics). Curr Opin Investig Drugs. 2001 May;2(5):650-3. DMYPRS9 RU https://pubmed.ncbi.nlm.nih.gov/11569941 DMEIW7K DI DMEIW7K DMEIW7K DN CMI-206 DMEIW7K MI TT2J34L DMEIW7K MN Arachidonate 5-lipoxygenase (5-LOX) DMEIW7K MT DTT DMEIW7K MA Modulator DMEIW7K RN DOI: 10.1016/0960-894X(95)00088-B DMEIW7K RU http://www.sciencedirect.com/science/article/pii/0960894X9500088B DMEIW7K DI DMEIW7K DMEIW7K DN CMI-206 DMEIW7K MI TTQL5VC DMEIW7K MN Platelet-activating factor receptor (PTAFR) DMEIW7K MT DTT DMEIW7K MA Modulator DMEIW7K RN DOI: 10.1016/0960-894X(95)00088-B DMEIW7K RU http://www.sciencedirect.com/science/article/pii/0960894X9500088B DMP3QAZ DI DMP3QAZ DMP3QAZ DN CNS-1237 DMP3QAZ MI TT1AQ50 DMP3QAZ MN Charybdotoxin receptor beta-4 (BKbeta4) DMP3QAZ MT DTT DMP3QAZ MA Modulator DMP3QAZ RN Effects of Ca2+ and Na+ channel inhibitors in vitro and in global cerebral ischaemia in vivo. Eur J Pharmacol. 1997 Aug 6;332(2):121-31. DMP3QAZ RU https://pubmed.ncbi.nlm.nih.gov/9286613 DM03LZB DI DM03LZB DM03LZB DN CNS-1307 DM03LZB MI TT5TPI6 DM03LZB MN Opioid receptor sigma 1 (OPRS1) DM03LZB MT DTT DM03LZB MA Modulator DM03LZB RN Antitussives and substance abuse. Subst Abuse Rehabil. 2013 Nov 6;4:75-82. DM03LZB RU https://pubmed.ncbi.nlm.nih.gov/24648790 DMZ5N2I DI DMZ5N2I DMZ5N2I DN CNS-1531 DMZ5N2I MI TT9IK2Z DMZ5N2I MN N-methyl-D-aspartate receptor (NMDAR) DMZ5N2I MT DTT DMZ5N2I MA Modulator DMZ5N2I RN WO patent application no. 2009,0164,86, Use of nmda receptor antagonists for treatment of urologic tumors. DMZ5N2I RU http://worldwide.espacenet.com/publicationDetails/biblio?DB=worldwide.espacenet.com&II=0&ND=3&adjacent=true&locale=en_EP&FT=D&date=20090205&CC=WO&NR=2009016486A2&KC=A2 DMZY0SF DI DMZY0SF DMZY0SF DN CNS-5788 DMZY0SF MI TT9IK2Z DMZY0SF MN N-methyl-D-aspartate receptor (NMDAR) DMZY0SF MT DTT DMZY0SF MA Antagonist DMZY0SF RN Identification and characterization of a potential ischemia-selective N-methyl-D-aspartate (NMDA) receptor ion-channel blocker, CNS 5788. Bioorg Med Chem Lett. 2001 Feb 26;11(4):501-4. DMZY0SF RU https://pubmed.ncbi.nlm.nih.gov/11229757 DMU5TZD DI DMU5TZD DMU5TZD DN Co-152791 DMU5TZD MI TTEX6LM DMU5TZD MN GABA(A) receptor gamma-3 (GABRG3) DMU5TZD MT DTT DMU5TZD MA Modulator DMU5TZD RN Substituted 3beta-phenylethynyl derivatives of 3alpha-hydroxy-5alpha-pregnan-20-one: remarkably potent neuroactive steroid modulators of gamma-aminobutyric acidA receptors. J Pharmacol Exp Ther. 1998Oct;287(1):198-207. DMU5TZD RU https://pubmed.ncbi.nlm.nih.gov/9765338 DMGIZHX DI DMGIZHX DMGIZHX DN Co-60549 DMGIZHX MI TTGXH6N DMGIZHX MN GABA(A) receptor delta (GABRD) DMGIZHX MT DTT DMGIZHX MA Modulator DMGIZHX RN Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800007012) DMGIZHX RU http://adisinsight.springer.com/drugs/800007012 DMQESM7 DI DMQESM7 DMQESM7 DN Cordil DMQESM7 MI TTQ38E9 DMQESM7 MN Sodium/potassium-transporting ATPase (SPT ATPase) DMQESM7 MT DTT DMQESM7 MA Modulator DMQESM7 RN WO patent application no. 1995,0085,58, Novel deoxy and oxygen-substituted sugar-containing 14-aminosteroid compounds. DMQESM7 RU http://www.google.com/patents/WO1995008558A1?cl=en DMO3486 DI DMO3486 DMO3486 DN COSALANE DMO3486 MI TTC24WT DMO3486 MN C-C chemokine receptor type 1 (CCR1) DMO3486 MT DTT DMO3486 MA Inhibitor DMO3486 RN Inhibition of RANTES/CCR1-mediated chemotaxis by cosalane and related compounds. Bioorg Med Chem Lett. 2001 Jan 8;11(1):59-62. DMO3486 RU https://pubmed.ncbi.nlm.nih.gov/11140734 DMS23JX DI DMS23JX DMS23JX DN CP-0597 DMS23JX MI TTGY8IW DMS23JX MN B2 bradykinin receptor (BDKRB2) DMS23JX MT DTT DMS23JX MA Antagonist DMS23JX RN CP-0597, a selective bradykinin B2 receptor antagonist, inhibits brain injury in a rat model of reversible middle cerebral artery occlusion. Stroke. 1997 Jul;28(7):1430-6. DMS23JX RU https://pubmed.ncbi.nlm.nih.gov/9227696 DMDQBAL DI DMDQBAL DMDQBAL DN CP-293019 DMDQBAL MI TTSQIFT DMDQBAL MN 5-HT 1A receptor (HTR1A) DMDQBAL MT DTT DMDQBAL MA Inhibitor DMDQBAL RN Synthesis, SAR and pharmacology of CP-293,019: a potent, selective dopamine D4 receptor antagonist. Bioorg Med Chem Lett. 1998 Apr 7;8(7):725-30. DMDQBAL RU https://pubmed.ncbi.nlm.nih.gov/9871530 DMCIXYR DI DMCIXYR DMCIXYR DN CP-331 DMCIXYR MI TTQHJ1K DMCIXYR MN Histamine H2 receptor (H2R) DMCIXYR MT DTT DMCIXYR MA Modulator DMCIXYR RN Conjugation of chlorin p(6) to histamine enhances its cellular uptake and phototoxicity in oral cancer cells. Cancer Chemother Pharmacol. 2011 Aug;68(2):359-69. DMCIXYR RU https://pubmed.ncbi.nlm.nih.gov/20978762 DMDEPKM DI DMDEPKM DMDEPKM DN CP-471358 DMDEPKM MI TT1GHVO DMDEPKM MN Matrix metalloproteinase (MMP) DMDEPKM MT DTT DMDEPKM MA Inhibitor DMDEPKM RN A phase I and pharmacologic study of the matrix metalloproteinase inhibitor CP-471,358 in patients with advanced solid tumors. Cancer Chemother Pharmacol. 2005 Feb;55(2):136-42. DMDEPKM RU https://pubmed.ncbi.nlm.nih.gov/15592721 DMIZMJD DI DMIZMJD DMIZMJD DN CP-663427 DMIZMJD MI TT7WZIJ DMIZMJD MN CAAX farnesyltransferase beta (FNTB) DMIZMJD MT DTT DMIZMJD MA Inhibitor DMIZMJD RN WO patent application no. 2011,0881,26, Treatment of viral infection with prenyltransferase inhibitors. DMIZMJD RU http://worldwide.espacenet.com/publicationDetails/biblio?DB=worldwide.espacenet.com&II=0&ND=3&adjacent=true&locale=en_EP&FT=D&date=20110721&CC=WO&NR=2011088126A2&KC=A2 DMWFI4A DI DMWFI4A DMWFI4A DN CP-67015 DMWFI4A MI TTN6J5F DMWFI4A MN Bacterial DNA gyrase (Bact gyrase) DMWFI4A MT DTT DMWFI4A MA Modulator DMWFI4A RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. DMWFI4A RU https://www.fda.gov/ DMSOT07 DI DMSOT07 DMSOT07 DN CP-83101 DMSOT07 MI TTPADOQ DMSOT07 MN HMG-CoA reductase (HMGCR) DMSOT07 MT DTT DMSOT07 MA Inhibitor DMSOT07 RN Efficacy, tissue distribution and biliary excretion of methyl (3R*,5S*)-(E)-3,5-dihydroxy-9,9-diphenyl-6,8-nonadienoate (CP-83101), a hepatoselective inhibitor of HMG-CoA reductase activity in the rat. Biochem Pharmacol. 1990 Sep 15;40(6):1281-93. DMSOT07 RU https://pubmed.ncbi.nlm.nih.gov/2403382 DMEJBQY DI DMEJBQY DMEJBQY DN CP-903397 DMEJBQY MI TTEX248 DMEJBQY MN Dopamine D2 receptor (D2R) DMEJBQY MT DTT DMEJBQY MA Modulator DMEJBQY RN Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800025558) DMEJBQY RU http://adisinsight.springer.com/drugs/800025558 DM4HYWR DI DM4HYWR DM4HYWR DN CP-96345 DM4HYWR MI TTZPO1L DM4HYWR MN Substance-P receptor (TACR1) DM4HYWR MT DTT DM4HYWR MA Inhibitor DM4HYWR RN 2-Aryl-1-azabicyclo[2.2.2]octanes as novel nonpeptide substance P antagonists, Bioorg. Med. Chem. Lett. 4(6):839-842 (1994). DM4HYWR RU http://www.sciencedirect.com/science/article/pii/S0960894X01808593 DM8NVZQ DI DM8NVZQ DM8NVZQ DN CR-1795 DM8NVZQ MI TTCG0AL DM8NVZQ MN Cholecystokinin receptor type A (CCKAR) DM8NVZQ MT DTT DM8NVZQ MA Inhibitor DM8NVZQ RN Biological properties of (R)-4-benzamido-5-oxopentanoic basic derivatives as CCK-antagonists, Bioorg. Med. Chem. Lett. 3(5):861-866 (1993). DM8NVZQ RU http://www.sciencedirect.com/science/article/pii/S0960894X00806812 DM51XDU DI DM51XDU DM51XDU DN CR-2991 DM51XDU MI TT34BHT DM51XDU MN Adrenergic receptor alpha-1D (ADRA1D) DM51XDU MT DTT DM51XDU MA Antagonist DM51XDU RN WO patent application no. 2006,1244,90, Heterocycles as nicotinic acid receptor agonists for the treatment of dyslipidemia. DM51XDU RU http://worldwide.espacenet.com/publicationDetails/biblio?DB=worldwide.espacenet.com&II=0&ND=3&adjacent=true&locale=en_EP&FT=D&date=20061123&CC=WO&NR=2006124490A2&KC=A2 DM1MBG9 DI DM1MBG9 DM1MBG9 DN CR-3124 DM1MBG9 MI TTNXLKE DM1MBG9 MN 5-HT 3 receptor (5HT3R) DM1MBG9 MT DTT DM1MBG9 MA Modulator DM1MBG9 RN Physicochemical and biopharmaceutical characterization of endo-2-(8-methyl-8-azabicyclo[3.2.1]oct-3-yl)-2,3-dihydro-1H-benz[e]isoindol-1-one (CR312... J Pharm Sci. 2006 Dec;95(12):2706-21. DM1MBG9 RU https://www.ncbi.nlm.nih.gov/pubmed/16924684 DMTPDX7 DI DMTPDX7 DMTPDX7 DN CR-3834 DMTPDX7 MI TT8DBY3 DMTPDX7 MN Angiotensin II receptor type-1 (AGTR1) DMTPDX7 MT DTT DMTPDX7 MA Antagonist DMTPDX7 RN Pharmacokinetic study of a new angiotensin-AT1 antagonist by HPLC. J Pharm Biomed Anal. 2008 Sep 29;48(2):422-7. DMTPDX7 RU https://pubmed.ncbi.nlm.nih.gov/18514458 DMRNB7V DI DMRNB7V DMRNB7V DN CRA-028129 DMRNB7V MI TTUMQVO DMRNB7V MN Cathepsin S (CTSS) DMRNB7V MT DTT DMRNB7V MA Inhibitor DMRNB7V RN Phase I clinical trial for cathepsin S inhibitor for psoriasis begins. Celera Genomics. 2005. DMRNB7V RU http://www.newsrx.com/newsletters/FDA-Law-Weekly/2005-10-20/10172005333500FL.html DM1E7H3 DI DM1E7H3 DM1E7H3 DN CS-204 DM1E7H3 MI TTJ584C DM1E7H3 MN Peroxisome proliferator-activated receptor alpha (PPARA) DM1E7H3 MT DTT DM1E7H3 MA Agonist DM1E7H3 RN Peroxisome Proliferators-Activated Receptor (PPAR) Modulators and Metabolic Disorders. PPAR Res. 2008; 2008: 679137. DM1E7H3 RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2430035/ DM1E7H3 DI DM1E7H3 DM1E7H3 DN CS-204 DM1E7H3 MI TT2JWF6 DM1E7H3 MN Peroxisome proliferator-activated receptor delta (PPARD) DM1E7H3 MT DTT DM1E7H3 MA Agonist DM1E7H3 RN Peroxisome Proliferators-Activated Receptor (PPAR) Modulators and Metabolic Disorders. PPAR Res. 2008; 2008: 679137. DM1E7H3 RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2430035/ DM1E7H3 DI DM1E7H3 DM1E7H3 DN CS-204 DM1E7H3 MI TTZMAO3 DM1E7H3 MN Peroxisome proliferator-activated receptor gamma (PPAR-gamma) DM1E7H3 MT DTT DM1E7H3 MA Agonist DM1E7H3 RN Peroxisome Proliferators-Activated Receptor (PPAR) Modulators and Metabolic Disorders. PPAR Res. 2008; 2008: 679137. DM1E7H3 RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2430035/ DMFJ4VT DI DMFJ4VT DMFJ4VT DN CS-207 DMFJ4VT MI TTJ584C DMFJ4VT MN Peroxisome proliferator-activated receptor alpha (PPARA) DMFJ4VT MT DTT DMFJ4VT MA Agonist DMFJ4VT RN Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800026848) DMFJ4VT RU http://adisinsight.springer.com/drugs/800026848 DM84KOY DI DM84KOY DM84KOY DN CT-1746 DM84KOY MI TT6X50U DM84KOY MN Matrix metalloproteinase-9 (MMP-9) DM84KOY MT DTT DM84KOY MA Modulator DM84KOY RN Conversion of highly malignant colon cancer from an aggressive to a controlled disease by oral administration of a metalloproteinase inhibitor. Clin Exp Metastasis. 1997 Mar;15(2):184-95. DM84KOY RU https://pubmed.ncbi.nlm.nih.gov/9062395 DMQBULC DI DMQBULC DMQBULC DN CV 6209 DMQBULC MI TTQL5VC DMQBULC MN Platelet-activating factor receptor (PTAFR) DMQBULC MT DTT DMQBULC MA Modulator DMQBULC RN CV-6209, a highly potent antagonist of platelet activating factor in vitro and in vivo. J Pharmacol Exp Ther. 1987 Jul;242(1):263-8. DMQBULC RU https://www.ncbi.nlm.nih.gov/pubmed/3612533 DMMDO3X DI DMMDO3X DMMDO3X DN CVS-995 DMMDO3X MI TT6L509 DMMDO3X MN Coagulation factor IIa (F2) DMMDO3X MT DTT DMMDO3X MA Inhibitor DMMDO3X RN Synthesis, structure, and structure-activity relationships of divalent thrombin inhibitors containing an alpha-keto-amide transition-state mimetic. Protein Sci. 1996 Mar;5(3):422-33. DMMDO3X RU https://pubmed.ncbi.nlm.nih.gov/8868478 DMPWZCI DI DMPWZCI DMPWZCI DN CVT-1 DMPWZCI MI TTTRNQW DMPWZCI MN Bile-salt-activated lipase (CEL) DMPWZCI MT DTT DMPWZCI MA Modulator DMPWZCI RN Lack of effect of cholesterol esterase inhibitor CVT-1 on cholesterol absorption and LDL cholesterol in humans. Cardiovasc Drugs Ther. 1999 Sep;13(5):449-54. DMPWZCI RU https://pubmed.ncbi.nlm.nih.gov/10547226 DM0X147 DI DM0X147 DM0X147 DN CY-1748 DM0X147 MI TTD26RC DM0X147 MN Cell adhesion molecule (CADM) DM0X147 MT DTT DM0X147 MA Modulator DM0X147 RN US patent application no. 6,492,332, Irrigation solution and methods for inhibition of tumor cell adhesion, pain and inflammation. DM0X147 RU https://www.google.com/patents/US6492332 DMPBCLA DI DMPBCLA DMPBCLA DN CY-9652 DMPBCLA MI TT6S84X DMPBCLA MN Integrin alpha-4/beta-1 (ITGA4/B1) DMPBCLA MT DTT DMPBCLA MA Antagonist DMPBCLA RN US patent application no. 2010,0278,784, Methods and compositions for treating skin conditions. DMPBCLA RU https://www.google.com.ar/patents/US20100278784 DM17NYA DI DM17NYA DM17NYA DN CYC-103 DM17NYA MI TT0PG8F DM17NYA MN Cyclin-dependent kinase 4 (CDK4) DM17NYA MT DTT DM17NYA MA Inhibitor DM17NYA RN Liposarcoma: molecular genetics and therapeutics. Sarcoma. 2011;2011:483154. DM17NYA RU https://pubmed.ncbi.nlm.nih.gov/21253554 DM17NYA DI DM17NYA DM17NYA DN CYC-103 DM17NYA MI TTO0FDJ DM17NYA MN Cyclin-dependent kinase 6 (CDK6) DM17NYA MT DTT DM17NYA MA Inhibitor DM17NYA RN WO patent application no. 2007,0898,78, Sutures and anti-scarring agents. DM17NYA RU http://worldwide.espacenet.com/publicationDetails/biblio?DB=worldwide.espacenet.com&II=0&ND=3&adjacent=true&locale=en_EP&FT=D&date=20070809&CC=WO&NR=2007089878A2&KC=A2 DMF8TCI DI DMF8TCI DMF8TCI DN CZ-112 DMF8TCI MI TTGTQHC DMF8TCI MN DNA topoisomerase I (TOP1) DMF8TCI MT DTT DMF8TCI MA Inhibitor DMF8TCI RN Pharmacology of camptothecin esters. Ann N Y Acad Sci. 2000;922:216-23. DMF8TCI RU https://pubmed.ncbi.nlm.nih.gov/11193897 DME07ML DI DME07ML DME07ML DN D-21775 DME07ML MI TT8R70G DME07ML MN Gonadotropin-releasing hormone receptor (GNRHR) DME07ML MT DTT DME07ML MA Modulator DME07ML RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 256). DME07ML RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=256 DM7FTCV DI DM7FTCV DM7FTCV DN D-22888 DM7FTCV MI TTZ97H5 DM7FTCV MN Phosphodiesterase 4A (PDE4A) DM7FTCV MT DTT DM7FTCV MA Inhibitor DM7FTCV RN Effects of a selective PDE4 inhibitor, D-22888, on human airways and eosinophils in vitro and late phase allergic pulmonary eosinophilia in guinea pigs. Pulm Pharmacol Ther. 1998 Feb;11(1):13-21. DM7FTCV RU https://pubmed.ncbi.nlm.nih.gov/9802959 DM7FTCV DI DM7FTCV DM7FTCV DN D-22888 DM7FTCV MI TTVIAT9 DM7FTCV MN Phosphodiesterase 4B (PDE4B) DM7FTCV MT DTT DM7FTCV MA Modulator DM7FTCV RN Effects of a selective PDE4 inhibitor, D-22888, on human airways and eosinophils in vitro and late phase allergic pulmonary eosinophilia in guinea pigs. Pulm Pharmacol Ther. 1998 Feb;11(1):13-21. DM7FTCV RU https://pubmed.ncbi.nlm.nih.gov/9802959 DM7FTCV DI DM7FTCV DM7FTCV DN D-22888 DM7FTCV MI TTSKMI8 DM7FTCV MN Phosphodiesterase 4D (PDE4D) DM7FTCV MT DTT DM7FTCV MA Modulator DM7FTCV RN Effects of a selective PDE4 inhibitor, D-22888, on human airways and eosinophils in vitro and late phase allergic pulmonary eosinophilia in guinea pigs. Pulm Pharmacol Ther. 1998 Feb;11(1):13-21. DM7FTCV RU https://pubmed.ncbi.nlm.nih.gov/9802959 DMBJAUC DI DMBJAUC DMBJAUC DN D-26344 DMBJAUC MI TT8R70G DMBJAUC MN Gonadotropin-releasing hormone receptor (GNRHR) DMBJAUC MT DTT DMBJAUC MA Inhibitor DMBJAUC RN Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800003256) DMBJAUC RU http://adisinsight.springer.com/drugs/800003256 DM0YFZ6 DI DM0YFZ6 DM0YFZ6 DN D-43787 DM0YFZ6 MI TTATDGJ DM0YFZ6 MN Calcium signal-modulating cyclophilin ligand (CAML) DM0YFZ6 MT DTT DM0YFZ6 MA Binder DM0YFZ6 RN Anti-inflammatory effects of a cyclosporine receptor-binding compound, D-43787. J Pharmacol Exp Ther. 2002 May;301(2):738-46. DM0YFZ6 RU https://pubmed.ncbi.nlm.nih.gov/11961080 DMXHN6U DI DMXHN6U DMXHN6U DN D-5410 DMXHN6U MI TT1GHVO DMXHN6U MN Matrix metalloproteinase (MMP) DMXHN6U MT DTT DMXHN6U MA Modulator DMXHN6U RN US patent application no. US20080187572 A1. DMXHN6U RU https://www.google.com.ar/patents/US20080187572 DMHNZ1P DI DMHNZ1P DMHNZ1P DN D-9120 DMHNZ1P MI TT1GHVO DMHNZ1P MN Matrix metalloproteinase (MMP) DMHNZ1P MT DTT DMHNZ1P MA Inhibitor DMHNZ1P RN WO patent application no. 2006,1139,93, Matrix metalloproteinase inhibitors of tgfss -induced subcapsular cataract formation. DMHNZ1P RU http://worldwide.espacenet.com/publicationDetails/biblio?DB=worldwide.espacenet.com&II=0&ND=3&adjacent=true&locale=en_EP&FT=D&date=20061102&CC=WO&NR=2006113993A1&KC=A1 DM3LJK5 DI DM3LJK5 DM3LJK5 DN DAA-1097 DM3LJK5 MI TTPTXIN DM3LJK5 MN Translocator protein (TSPO) DM3LJK5 MT DTT DM3LJK5 MA Agonist DM3LJK5 RN Neuropharmacological profile of peripheral benzodiazepine receptor agonists, DAA1097 and DAA1106. Life Sci. 1999;64(16):1455-64. DM3LJK5 RU https://pubmed.ncbi.nlm.nih.gov/10321725 DMP3X6Q DI DMP3X6Q DMP3X6Q DN Dacetuzumab DMP3X6Q MI TTIJP3Q DMP3X6Q MN TNF related activation protein (CD40LG) DMP3X6Q MT DTT DMP3X6Q MA Modulator DMP3X6Q RN A phase I study of dacetuzumab (SGN-40, a humanized anti-CD40 monoclonal antibody) in patients with chronic lymphocytic leukemia.Leuk Lymphoma.2010 Feb;51(2):228-35. DMP3X6Q RU https://www.ncbi.nlm.nih.gov/pubmed/20038235 DMZ8OMT DI DMZ8OMT DMZ8OMT DN DACTIMICIN DMZ8OMT MI TTOVFH2 DMZ8OMT MN Bacterial 30S ribosomal RNA (Bact 30S rRNA) DMZ8OMT MT DTT DMZ8OMT MA Inhibitor DMZ8OMT RN Aminoglycosides: Activity and Resistance. Antimicrob Agents Chemother. 1999 April; 43(4): 727-737. DMZ8OMT RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC89199/ DMFCMPS DI DMFCMPS DMFCMPS DN Daidzin DMFCMPS MI TTFLN4T DMFCMPS MN Mitochondrial aldehyde dehydrogenase (ALDH2) DMFCMPS MT DTT DMFCMPS MA Inhibitor DMFCMPS RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMFCMPS RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMHJAD4 DI DMHJAD4 DMHJAD4 DN Daniplestim DMHJAD4 MI TTENHJ0 DMHJAD4 MN Interleukin 3 receptor alpha (IL3RA) DMHJAD4 MT DTT DMHJAD4 MA Agonist DMHJAD4 RN The combined administration of daniplestim and Mpl ligand augments the hematopoietic reconstitution observed with single cytokine administration in a nonhuman primate model of myelosuppression. Stem Cells. 1998;16 Suppl 2:143-54. DMHJAD4 RU https://pubmed.ncbi.nlm.nih.gov/11012186 DM6IGRL DI DM6IGRL DM6IGRL DN DARGLITAZONE DM6IGRL MI TTZMAO3 DM6IGRL MN Peroxisome proliferator-activated receptor gamma (PPAR-gamma) DM6IGRL MT DTT DM6IGRL MA Agonist DM6IGRL RN The PPAR-gamma agonist, darglitazone, restores acute inflammatory responses to cerebral hypoxia-ischemia in the diabetic ob/ob mouse. J Cereb Blood Flow Metab. 2010 February; 30(2): 352-360. DM6IGRL RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2949120/ DM160FM DI DM160FM DM160FM DN Darodipine DM160FM MI TT5HONZ DM160FM MN Calcium channel unspecific (CaC) DM160FM MT DTT DM160FM MA Modulator DM160FM RN Effect of cromakalim on contractions in rabbit isolated renal artery in the presence and absence of extracellular Ca2+. Br J Pharmacol. 1989 Dec;98(4):1303-11. DM160FM RU https://pubmed.ncbi.nlm.nih.gov/2575415 DM160FM DI DM160FM DM160FM DN Darodipine DM160FM MI DE4LYSA DM160FM MN Cytochrome P450 3A4 (CYP3A4) DM160FM MT DME DM160FM MA Metabolism DM160FM RN Integrated analysis on the physicochemical properties of dihydropyridine calcium channel blockers in grapefruit juice interactions. Curr Pharm Biotechnol. 2012 Jul;13(9):1705-17. DM160FM RU https://www.ncbi.nlm.nih.gov/pubmed/?term=22039822 DMR80AL DI DMR80AL DMR80AL DN Datelliptium chloride DMR80AL MI TTGTQHC DMR80AL MN DNA topoisomerase I (TOP1) DMR80AL MT DTT DMR80AL MA Modulator DMR80AL RN Toxicity of the antitumoral drug datelliptium in hepatic cells: Use of models in vitro for the prediction of toxicity in vivo. Toxicol In Vitro. 1992 Jul;6(4):295-302. DMR80AL RU https://pubmed.ncbi.nlm.nih.gov/20732126 DMR80AL DI DMR80AL DMR80AL DN Datelliptium chloride DMR80AL MI TT0IHXV DMR80AL MN DNA topoisomerase II (TOP2) DMR80AL MT DTT DMR80AL MA Modulator DMR80AL RN Toxicity of the antitumoral drug datelliptium in hepatic cells: Use of models in vitro for the prediction of toxicity in vivo. Toxicol In Vitro. 1992 Jul;6(4):295-302. DMR80AL RU https://pubmed.ncbi.nlm.nih.gov/20732126 DMP9GFZ DI DMP9GFZ DMP9GFZ DN DAU-6285 DMP9GFZ MI TT07C3Y DMP9GFZ MN 5-HT 4 receptor (HTR4) DMP9GFZ MT DTT DMP9GFZ MA Modulator DMP9GFZ RN The novel 5-HT4 receptor antagonist DAU 6285 antagonizes 5-hydroxytryptamine-induced tachycardia in pigs. Eur J Pharmacol. 1993 Mar 23;233(2-3):295-7. DMP9GFZ RU https://www.ncbi.nlm.nih.gov/pubmed/8467876 DMJUW8H DI DMJUW8H DMJUW8H DN Dazoxiben DMJUW8H MI TTKNWZ4 DMJUW8H MN Thromboxane-A synthase (TBXAS1) DMJUW8H MT DTT DMJUW8H MA Inhibitor DMJUW8H RN Metabolic protection of the reperfused canine endocardium by the thromboxane synthetase inhibitor, dazoxiben. Prostaglandins Leukot Essent Fatty Acids. 1988 Jul;33(1):13-22. DMJUW8H RU https://pubmed.ncbi.nlm.nih.gov/3054935 DMTXPSB DI DMTXPSB DMTXPSB DN DB-200 DMTXPSB MI TTDL0NY DMTXPSB MN Carnitine O-palmitoyltransferase I (CPT1B) DMTXPSB MT DTT DMTXPSB MA Inhibitor DMTXPSB RN Comparison of the effects of carnitine palmitoyltransferase-1 and -2 inhibitors on rat heart hypertrophy. Cardioscience. 1994 Sep;5(3):193-7. DMTXPSB RU https://pubmed.ncbi.nlm.nih.gov/7827256 DM8GHT2 DI DM8GHT2 DM8GHT2 DN DBO-11 DM8GHT2 MI TTKWM86 DM8GHT2 MN Opioid receptor mu (MOP) DM8GHT2 MT DTT DM8GHT2 MA Agonist DM8GHT2 RN Emerging analgesics in cancer pain management. Expert Opin Emerg Drugs. 2005 Feb;10(1):151-71. DM8GHT2 RU https://pubmed.ncbi.nlm.nih.gov/15757410 DMFJ3UW DI DMFJ3UW DMFJ3UW DN DBO-17 DMFJ3UW MI TTKWM86 DMFJ3UW MN Opioid receptor mu (MOP) DMFJ3UW MT DTT DMFJ3UW MA Agonist DMFJ3UW RN Emerging analgesics in cancer pain management. Expert Opin Emerg Drugs. 2005 Feb;10(1):151-71. DMFJ3UW RU https://pubmed.ncbi.nlm.nih.gov/15757410 DM0JDCS DI DM0JDCS DM0JDCS DN DBO-83 DM0JDCS MI TTJSZTB DM0JDCS MN Nicotinic acetylcholine receptor (nAChR) DM0JDCS MT DTT DM0JDCS MA Agonist DM0JDCS RN The therapeutic potential of nicotinic acetylcholine receptor agonists for pain control. Expert Opin Investig Drugs. 2001 Oct;10(10):1819-30. DM0JDCS RU https://pubmed.ncbi.nlm.nih.gov/11772288 DMCDMWJ DI DMCDMWJ DMCDMWJ DN DC-015 DMCDMWJ MI TTG28O6 DMCDMWJ MN Adrenergic receptor Alpha-1 (ADRA1) DMCDMWJ MT DTT DMCDMWJ MA Antagonist DMCDMWJ RN Antihypertensive and Hypolipidemic Effects of DC-015, a Novel, Potent and Specific alpha(1)-Adrenoceptor Antagonist: Comparison with Prazosin in Spontaneously Hypertensive Rats. J Biomed Sci. 1996 Apr;3(2):108-116. DMCDMWJ RU https://pubmed.ncbi.nlm.nih.gov/11725091 DM5VFR0 DI DM5VFR0 DM5VFR0 DN DHP-218 DM5VFR0 MI TT5HONZ DM5VFR0 MN Calcium channel unspecific (CaC) DM5VFR0 MT DTT DM5VFR0 MA Modulator DM5VFR0 RN Effect of DHP-218, a novel dihydropyridine phosphonate, on atrioventricular nodal conductivity compared with its vascular effect in dogs. J Cardiovasc Pharmacol. 1987 Sep;10(3):274-9. DM5VFR0 RU https://pubmed.ncbi.nlm.nih.gov/2444774 DM6LP0R DI DM6LP0R DM6LP0R DN Dianicline+rimonabant DM6LP0R MI TT6OEDT DM6LP0R MN Cannabinoid receptor 1 (CB1) DM6LP0R MT DTT DM6LP0R MA Agonist DM6LP0R RN Emerging drugs for the treatment of tobacco dependence. Expert Opin Emerg Drugs. 2009 Mar;14(1):23-32. DM6LP0R RU https://pubmed.ncbi.nlm.nih.gov/19278367 DM6LP0R DI DM6LP0R DM6LP0R DN Dianicline+rimonabant DM6LP0R MI TTEX248 DM6LP0R MN Dopamine D2 receptor (D2R) DM6LP0R MT DTT DM6LP0R MA Antagonist DM6LP0R RN Potent activation of dopamine D3/D2 heterodimers by the antiparkinsonian agents, S32504, pramipexole and ropinirole. J Neurochem. 2003 Nov;87(3):631-41. DM6LP0R RU https://pubmed.ncbi.nlm.nih.gov/14535946 DM6LP0R DI DM6LP0R DM6LP0R DN Dianicline+rimonabant DM6LP0R MI TT4C8EA DM6LP0R MN Dopamine D3 receptor (D3R) DM6LP0R MT DTT DM6LP0R MA Antagonist DM6LP0R RN Potent activation of dopamine D3/D2 heterodimers by the antiparkinsonian agents, S32504, pramipexole and ropinirole. J Neurochem. 2003 Nov;87(3):631-41. DM6LP0R RU https://pubmed.ncbi.nlm.nih.gov/14535946 DM6LP0R DI DM6LP0R DM6LP0R DN Dianicline+rimonabant DM6LP0R MI TTJSZTB DM6LP0R MN Nicotinic acetylcholine receptor (nAChR) DM6LP0R MT DTT DM6LP0R MA Agonist DM6LP0R RN Emerging drugs for the treatment of tobacco dependence. Expert Opin Emerg Drugs. 2009 Mar;14(1):23-32. DM6LP0R RU https://pubmed.ncbi.nlm.nih.gov/19278367 DM61BWZ DI DM61BWZ DM61BWZ DN Diaspirin crosslinked hemoglobin DM61BWZ MI TTQO71U DM61BWZ MN Hemoglobin (HB) DM61BWZ MT DTT DM61BWZ MA Modulator DM61BWZ RN Diaspirin cross-linked hemoglobin infusion did not influence base deficit and lactic acid levels in two clinical trials of traumatic hemorrhagic shock patient resuscitation. J Trauma. 2010 May;68(5):1158-71. DM61BWZ RU https://pubmed.ncbi.nlm.nih.gov/20145575 DMB74CM DI DMB74CM DMB74CM DN DIAVERIDINE DMB74CM MI TTV8DM2 DMB74CM MN Bacterial Dihydrofolate reductase (Bact DHFR) DMB74CM MT DTT DMB74CM MA Modulator DMB74CM RN Acute and sub-chronic toxicity study of diaveridine in Wistar rats.Regul Toxicol Pharmacol.2015 Oct;73(1):232-40. DMB74CM RU https://www.ncbi.nlm.nih.gov/pubmed/26209270 DMAK3V7 DI DMAK3V7 DMAK3V7 DN DIO-901 DMAK3V7 MI TT9O6WS DMAK3V7 MN Glucagon receptor (GCGR) DMAK3V7 MT DTT DMAK3V7 MA Agonist DMAK3V7 RN Effects of low-dose and high-dose glucagon on glucose production and gluconeogenesis in humans. Metabolism. 2000 Jan;49(1):39-46. DMAK3V7 RU https://pubmed.ncbi.nlm.nih.gov/10647062 DMO3XBP DI DMO3XBP DMO3XBP DN Divaplon DMO3XBP MI TT1MPAY DMO3XBP MN GABA(A) receptor alpha-1 (GABRA1) DMO3XBP MT DTT DMO3XBP MA Inhibitor DMO3XBP RN (Imidazo[1,2-a]pyrimidin-2-yl)phenylmethanones and related compounds as potential nonsedative anxiolytics. J Med Chem. 1988 Jun;31(6):1220-6. DMO3XBP RU https://pubmed.ncbi.nlm.nih.gov/2897468 DMO3XBP DI DMO3XBP DMO3XBP DN Divaplon DMO3XBP MI TTNJYV2 DMO3XBP MN Gamma-aminobutyric acid receptor (GAR) DMO3XBP MT DTT DMO3XBP MA Inhibitor DMO3XBP RN (Imidazo[1,2-a]pyrimidin-2-yl)phenylmethanones and related compounds as potential nonsedative anxiolytics. J Med Chem. 1988 Jun;31(6):1220-6. DMO3XBP RU https://pubmed.ncbi.nlm.nih.gov/2897468 DMMGYXR DI DMMGYXR DMMGYXR DN Dizocilpine DMMGYXR MI TTJFY5U DMMGYXR MN Adenosine A3 receptor (ADORA3) DMMGYXR MT DTT DMMGYXR MA Inhibitor DMMGYXR RN 2-n-Butyl-9-methyl-8-[1,2,3]triazol-2-yl-9H-purin-6-ylamine and analogues as A2A adenosine receptor antagonists. Design, synthesis, and pharmacolog... J Med Chem. 2005 Nov 3;48(22):6887-96. DMMGYXR RU https://pubmed.ncbi.nlm.nih.gov/16250647 DMMGYXR DI DMMGYXR DMMGYXR DN Dizocilpine DMMGYXR MI TTLD29N DMMGYXR MN Glutamate receptor ionotropic NMDA 1 (NMDAR1) DMMGYXR MT DTT DMMGYXR MA Inhibitor DMMGYXR RN Synthesis and evaluation of 6,11-ethanohexahydrobenzo[b]quinolizidines: a new class of noncompetitive N-methyl-D-aspartate antagonists. J Med Chem. 1995 Jun 23;38(13):2483-9. DMMGYXR RU https://pubmed.ncbi.nlm.nih.gov/7608913 DMMGYXR DI DMMGYXR DMMGYXR DN Dizocilpine DMMGYXR MI TTKJEMQ DMMGYXR MN Glutamate receptor ionotropic NMDA 2A (NMDAR2A) DMMGYXR MT DTT DMMGYXR MA Inhibitor DMMGYXR RN Synthesis and evaluation of 6,11-ethanohexahydrobenzo[b]quinolizidines: a new class of noncompetitive N-methyl-D-aspartate antagonists. J Med Chem. 1995 Jun 23;38(13):2483-9. DMMGYXR RU https://pubmed.ncbi.nlm.nih.gov/7608913 DMMGYXR DI DMMGYXR DMMGYXR DN Dizocilpine DMMGYXR MI TTN9D8E DMMGYXR MN Glutamate receptor ionotropic NMDA 2B (NMDAR2B) DMMGYXR MT DTT DMMGYXR MA Inhibitor DMMGYXR RN Synthesis and evaluation of 6,11-ethanohexahydrobenzo[b]quinolizidines: a new class of noncompetitive N-methyl-D-aspartate antagonists. J Med Chem. 1995 Jun 23;38(13):2483-9. DMMGYXR RU https://pubmed.ncbi.nlm.nih.gov/7608913 DMNSDM1 DI DMNSDM1 DMNSDM1 DN DMP-696 DMNSDM1 MI TT7EFHR DMNSDM1 MN Corticotropin-releasing factor receptor 1 (CRHR1) DMNSDM1 MT DTT DMNSDM1 MA Inhibitor DMNSDM1 RN In vitro intrinsic clearance-based optimization of N3-phenylpyrazinones as corticotropin-releasing factor-1 (CRF1) receptor antagonists. J Med Chem. 2009 Jul 23;52(14):4161-72. DMNSDM1 RU https://pubmed.ncbi.nlm.nih.gov/19552436 DMGNUXC DI DMGNUXC DMGNUXC DN DMP-757 DMGNUXC MI TTJA1ZO DMGNUXC MN ITGB3 messenger RNA (ITGB3 mRNA) DMGNUXC MT DTT DMGNUXC MA Inhibitor DMGNUXC RN Synthesis and antiplatelet activity of DMP 757 analogs, Bioorg. Med. Chem. Lett. 5(18):2097-2100 (1995). DMGNUXC RU http://www.sciencedirect.com/science/article/pii/0960894X9500351S DMO26E7 DI DMO26E7 DMO26E7 DN DMP-811 DMO26E7 MI TTGN1ZA DMO26E7 MN Angiotensin II receptor (AGTR) DMO26E7 MT DTT DMO26E7 MA Modulator DMO26E7 RN Disposition of DMP 811 (L-708,404), a potent angiotensin II receptor antagonist, in the rat, monkey, and chimpanzee. Drug Metab Dispos. 1995 Oct;23(10):1104-9. DMO26E7 RU https://pubmed.ncbi.nlm.nih.gov/8654199 DMKU469 DI DMKU469 DMKU469 DN DMP-963 DMKU469 MI TT84ETX DMKU469 MN Human immunodeficiency virus Reverse transcriptase (HIV RT) DMKU469 MT DTT DMKU469 MA Inhibitor DMKU469 RN Effect of drug substance particle size on the characteristics of granulation manufactured in a high-shear mixer. AAPS PharmSciTech. 2000 December; 1(4): 55-61. DMKU469 RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2750457/ DMLBS83 DI DMLBS83 DMLBS83 DN DMPDDF DMLBS83 MI TTU6BFZ DMLBS83 MN Candida Thymidylate synthase (Candi TMP1) DMLBS83 MT DTT DMLBS83 MA Inhibitor DMLBS83 RN Folate analogues. 32. Synthesis and biological evaluation of 2-desamino-2-methyl-N10-propargyl-5,8-dideazafolic acid and related compounds. J Med Chem. 1989 Jun;32(6):1284-9. DMLBS83 RU https://pubmed.ncbi.nlm.nih.gov/2542557 DMXR3V1 DI DMXR3V1 DMXR3V1 DN DNP-004089 DMXR3V1 MI TT8JRS7 DMXR3V1 MN Beta-secretase (BACE) DMXR3V1 MT DTT DMXR3V1 MA Inhibitor DMXR3V1 RN US patent application no. 8,269,019, Inhibitors. DMXR3V1 RU http://www.google.co.in/patents/US8269019?cl=pt-PT DM6Q05K DI DM6Q05K DM6Q05K DN Dotarizine DM6Q05K MI TTYSN63 DM6Q05K MN 5-HT 2 receptor (5HT2R) DM6Q05K MT DTT DM6Q05K MA Modulator DM6Q05K RN Vasostabilizing effect of Dotarizine (Ca(2+)-channel blocker) on cerebrovascular reactivity in rabbits. Neurol Res. 2000 Mar;22(2):229-32. DM6Q05K RU https://pubmed.ncbi.nlm.nih.gov/10763515 DM6Q05K DI DM6Q05K DM6Q05K DN Dotarizine DM6Q05K MI DE4LYSA DM6Q05K MN Cytochrome P450 3A4 (CYP3A4) DM6Q05K MT DME DM6Q05K MA Metabolism DM6Q05K RN Integrated analysis on the physicochemical properties of dihydropyridine calcium channel blockers in grapefruit juice interactions. Curr Pharm Biotechnol. 2012 Jul;13(9):1705-17. DM6Q05K RU https://www.ncbi.nlm.nih.gov/pubmed/?term=22039822 DM4BPFV DI DM4BPFV DM4BPFV DN Doxorubicin-CEA conjugate DM4BPFV MI TT0IHXV DM4BPFV MN DNA topoisomerase II (TOP2) DM4BPFV MT DTT DM4BPFV MA Modulator DM4BPFV RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. DM4BPFV RU https://www.fda.gov/ DM4BPFV DI DM4BPFV DM4BPFV DN Doxorubicin-CEA conjugate DM4BPFV MI TTUTN1I DM4BPFV MN Human Deoxyribonucleic acid (hDNA) DM4BPFV MT DTT DM4BPFV MA Modulator DM4BPFV RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. DM4BPFV RU https://www.fda.gov/ DM4JBQD DI DM4JBQD DM4JBQD DN DPC-333 DM4JBQD MI TT6AZXG DM4JBQD MN TNF alpha converting enzyme (ADAM17) DM4JBQD MT DTT DM4JBQD MA Inhibitor DM4JBQD RN Emerging drugs for the treatment of chronic obstructive pulmonary disease. Expert Opin Emerg Drugs. 2006 May;11(2):275-91. DM4JBQD RU https://pubmed.ncbi.nlm.nih.gov/16634702 DM67VDK DI DM67VDK DM67VDK DN DPC-A78277 DM67VDK MI TT84ETX DM67VDK MN Human immunodeficiency virus Reverse transcriptase (HIV RT) DM67VDK MT DTT DM67VDK MA Inhibitor DM67VDK RN The chimpanzee (Pan troglodytes) as a pharmacokinetic model for selection of drug candidates: model characterization and application. Drug Metab Dispos. 2004 Dec;32(12):1359-69. DM67VDK RU https://pubmed.ncbi.nlm.nih.gov/15333515 DM1AQVE DI DM1AQVE DM1AQVE DN DPI-201-106 DM1AQVE MI TT2CJVK DM1AQVE MN Adrenergic receptor beta-2 (ADRB2) DM1AQVE MT DTT DM1AQVE MA Inhibitor DM1AQVE RN Use of the X-ray structure of the beta2-adrenergic receptor for drug discovery. Part 2: Identification of active compounds. Bioorg Med Chem Lett. 2008 Oct 15;18(20):5391-5. DM1AQVE RU https://pubmed.ncbi.nlm.nih.gov/18829308 DM1AQVE DI DM1AQVE DM1AQVE DN DPI-201-106 DM1AQVE MI TTRK8B9 DM1AQVE MN Sodium channel unspecific (NaC) DM1AQVE MT DTT DM1AQVE MA Modulator DM1AQVE RN Interaction between DPI 201-106 enantiomers at the cardiac sodium channel. Mol Pharmacol. 1990 Jan;37(1):17-24. DM1AQVE RU https://pubmed.ncbi.nlm.nih.gov/2153906 DMX4KIT DI DMX4KIT DMX4KIT DN Draculin DMX4KIT MI TTFEZ5Q DMX4KIT MN Coagulation factor IX (F9) DMX4KIT MT DTT DMX4KIT MA Modulator DMX4KIT RN Expression of biological activity of draculin, the anticoagulant factor from vampire bat saliva, is strictly dependent on the appropriate glycosylation of the native molecule. Biochim Biophys Acta. 1998 Oct 23;1425(2):291-9. DMX4KIT RU https://pubmed.ncbi.nlm.nih.gov/9795244 DMX4KIT DI DMX4KIT DMX4KIT DN Draculin DMX4KIT MI TTCIHJA DMX4KIT MN Coagulation factor Xa (F10) DMX4KIT MT DTT DMX4KIT MA Modulator DMX4KIT RN Expression of biological activity of draculin, the anticoagulant factor from vampire bat saliva, is strictly dependent on the appropriate glycosylation of the native molecule. Biochim Biophys Acta. 1998 Oct 23;1425(2):291-9. DMX4KIT RU https://pubmed.ncbi.nlm.nih.gov/9795244 DM6EJVF DI DM6EJVF DM6EJVF DN Droxinavir hydrochloride DM6EJVF MI TT5FNQT DM6EJVF MN Human immunodeficiency virus Protease (HIV PR) DM6EJVF MT DTT DM6EJVF MA Modulator DM6EJVF RN A mutation in human immunodeficiency virus type 1 protease at position 88, located outside the active site, confers resistance to the hydroxyethylurea inhibitor SC-55389A. Antimicrob Agents Chemother. 1997 Mar;41(3):515-22. DM6EJVF RU https://pubmed.ncbi.nlm.nih.gov/9055985 DMAE43P DI DMAE43P DMAE43P DN DSP-7238 DMAE43P MI TTDIGC1 DMAE43P MN Dipeptidyl peptidase 4 (DPP-4) DMAE43P MT DTT DMAE43P MA Inhibitor DMAE43P RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1612). DMAE43P RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1612 DMX5SN8 DI DMX5SN8 DMX5SN8 DN Du-123015 DMX5SN8 MI TTSQIFT DMX5SN8 MN 5-HT 1A receptor (HTR1A) DMX5SN8 MT DTT DMX5SN8 MA Modulator DMX5SN8 RN Neither in vivo MRI nor behavioural assessment indicate therapeutic efficacy for a novel 5HT1A agonist in rat models of ischaemic stroke. BMC Neuroscience 2009, 10:82. DMX5SN8 RU http://www.biomedcentral.com/1471-2202/10/82 DM87ZWP DI DM87ZWP DM87ZWP DN DU-1777 DM87ZWP MI TTL69WB DM87ZWP MN Angiotensin-converting enzyme (ACE) DM87ZWP MT DTT DM87ZWP MA Inhibitor DM87ZWP RN Antihypertensive properties of a new long-acting angiotensin converting enzyme inhibitor in renin-dependent and independent hypertensive models. Arzneimittelforschung. 1995 Aug;45(8):853-8. DM87ZWP RU https://pubmed.ncbi.nlm.nih.gov/7575746 DMZOCHT DI DMZOCHT DMZOCHT DN DuP 714 DMZOCHT MI TT6L509 DMZOCHT MN Coagulation factor IIa (F2) DMZOCHT MT DTT DMZOCHT MA Inhibitor DMZOCHT RN Anticoagulation: the present and future. Clin Appl Thromb Hemost. 2001 Jul;7(3):195-204. DMZOCHT RU https://pubmed.ncbi.nlm.nih.gov/11441979 DMJGCYO DI DMJGCYO DMJGCYO DN DuP-129 DMJGCYO MI TTMF541 DMJGCYO MN Liver carboxylesterase (CES1) DMJGCYO MT DTT DMJGCYO MA Inhibitor DMJGCYO RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2592). DMJGCYO RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2592 DM7YORJ DI DM7YORJ DM7YORJ DN DuP-630 DM7YORJ MI TTOQ9GZ DM7YORJ MN Cytochrome P450 reductase (P450) DM7YORJ MT DTT DM7YORJ MA Modulator DM7YORJ RN CN patent application no. 1096855, Composition produced by treatment and induction of nitrogen mono oxide synthase expressed matter, and use thereof. DM7YORJ RU http://www.google.com/patents/CN1096855C?cl=en DM872CU DI DM872CU DM872CU DN DuP-983 DM872CU MI TTOQ9GZ DM872CU MN Cytochrome P450 reductase (P450) DM872CU MT DTT DM872CU MA Modulator DM872CU RN CN patent application no. 1096855, Composition produced by treatment and induction of nitrogen mono oxide synthase expressed matter, and use thereof. DM872CU RU http://www.google.com/patents/CN1096855C?cl=en DMKNJM7 DI DMKNJM7 DMKNJM7 DN DV-7028 DMKNJM7 MI TTJQOD7 DMKNJM7 MN 5-HT 2A receptor (HTR2A) DMKNJM7 MT DTT DMKNJM7 MA Agonist DMKNJM7 RN Vascular and cardiac effects of DV-7028, a selective, 5-HT2-receptor antagonist in rats. J Cardiovasc Pharmacol. 1998 Aug;32(2):266-73. DMKNJM7 RU https://pubmed.ncbi.nlm.nih.gov/9700989 DM3L0T1 DI DM3L0T1 DM3L0T1 DN DW-1350 DM3L0T1 MI TTN53ZF DM3L0T1 MN Leukotriene B4 receptor 1 (LTB4R) DM3L0T1 MT DTT DM3L0T1 MA Modulator DM3L0T1 RN Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800026850) DM3L0T1 RU http://adisinsight.springer.com/drugs/800026850 DM2PVMZ DI DM2PVMZ DM2PVMZ DN E-0722 DM2PVMZ MI TTFBNVI DM2PVMZ MN Aldose reductase (AKR1B1) DM2PVMZ MT DTT DM2PVMZ MA Modulator DM2PVMZ RN Aldose reductase inhibitors and prevention of galactose cataracts in rats. Invest Ophthalmol Vis Sci. 1989 Jul;30(7):1623-32. DM2PVMZ RU https://pubmed.ncbi.nlm.nih.gov/2545646 DMD4GQ8 DI DMD4GQ8 DMD4GQ8 DN E-2011 DMD4GQ8 MI TT3WG5C DMD4GQ8 MN Monoamine oxidase type A (MAO-A) DMD4GQ8 MT DTT DMD4GQ8 MA Modulator DMD4GQ8 RN Species differences and mechanism of the epimerization of a new MAO-A inhibitor. Xenobiotica. 1998 Mar;28(3):269-80. DMD4GQ8 RU https://pubmed.ncbi.nlm.nih.gov/9574815 DMZWU8V DI DMZWU8V DMZWU8V DN E-2040 DMZWU8V MI TTYSN63 DMZWU8V MN 5-HT 2 receptor (5HT2R) DMZWU8V MT DTT DMZWU8V MA Modulator DMZWU8V RN Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800009126) DMZWU8V RU http://adisinsight.springer.com/drugs/800009126 DMZWU8V DI DMZWU8V DMZWU8V DN E-2040 DMZWU8V MI TTEX248 DMZWU8V MN Dopamine D2 receptor (D2R) DMZWU8V MT DTT DMZWU8V MA Modulator DMZWU8V RN Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800009126) DMZWU8V RU http://adisinsight.springer.com/drugs/800009126 DMZWU8V DI DMZWU8V DMZWU8V DN E-2040 DMZWU8V MI TT4C8EA DMZWU8V MN Dopamine D3 receptor (D3R) DMZWU8V MT DTT DMZWU8V MA Modulator DMZWU8V RN Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800009126) DMZWU8V RU http://adisinsight.springer.com/drugs/800009126 DMQKEHA DI DMQKEHA DMQKEHA DN E-2050 DMQKEHA MI TT5HONZ DMQKEHA MN Calcium channel unspecific (CaC) DMQKEHA MT DTT DMQKEHA MA Modulator DMQKEHA RN Solubility of E2050 at various pH: a case in which apparent solubility is affected by the amount of excess solid. J Pharm Sci. 2002 Jun;91(6):1445-55. DMQKEHA RU https://www.ncbi.nlm.nih.gov/pubmed/12115844 DMAU0FP DI DMAU0FP DMAU0FP DN E-2070 DMAU0FP MI TTRK8B9 DMAU0FP MN Sodium channel unspecific (NaC) DMAU0FP MT DTT DMAU0FP MA Blocker DMAU0FP RN Emerging therapies for neuropathic pain. Expert Opin Emerg Drugs. 2005 Feb;10(1):95-108. DMAU0FP RU https://pubmed.ncbi.nlm.nih.gov/15757406 DMZ1JKX DI DMZ1JKX DMZ1JKX DN E-4080 DMZ1JKX MI TT1VOHK DMZ1JKX MN Potassium channel unspecific (KC) DMZ1JKX MT DTT DMZ1JKX MA Opener DMZ1JKX RN Ionic currents involved in vasodilating actions of E4080, a newly synthesized bradycardia-inducing agent, in dispersed smooth muscle cells of the rabbit portal vein. J Pharmacol Exp Ther. 1991 Dec;259(3):1396-403. DMZ1JKX RU https://pubmed.ncbi.nlm.nih.gov/1762086 DMR861Q DI DMR861Q DMR861Q DN E-5110 DMR861Q MI TTK0943 DMR861Q MN Prostaglandin G/H synthase (COX) DMR861Q MT DTT DMR861Q MA Modulator DMR861Q RN Effect of E-5110, a novel non-steroidal anti-inflammatory drug, on trimethadione metabolism as an indicator of hepatic drug-oxidizing capacity in beagle dog. Xenobiotica. 1994 Mar;24(3):215-20. DMR861Q RU https://pubmed.ncbi.nlm.nih.gov/8009884 DMV0QI1 DI DMV0QI1 DMV0QI1 DN E-5842 DMV0QI1 MI TT5TPI6 DMV0QI1 MN Opioid receptor sigma 1 (OPRS1) DMV0QI1 MT DTT DMV0QI1 MA Binder DMV0QI1 RN The pipeline and future of drug development in schizophrenia. Mol Psychiatry. 2007 Oct;12(10):904-22. DMV0QI1 RU https://pubmed.ncbi.nlm.nih.gov/17667958 DMTEY8W DI DMTEY8W DMTEY8W DN E-6276 DMTEY8W MI TT5TPI6 DMTEY8W MN Opioid receptor sigma 1 (OPRS1) DMTEY8W MT DTT DMTEY8W MA Binder DMTEY8W RN The pipeline and future of drug development in schizophrenia. Mol Psychiatry. 2007 Oct;12(10):904-22. DMTEY8W RU https://pubmed.ncbi.nlm.nih.gov/17667958 DM5ITJF DI DM5ITJF DM5ITJF DN EC-154 DM5ITJF MI TT78R5H DM5ITJF MN Heat shock protein 90 alpha (HSP90A) DM5ITJF MT DTT DM5ITJF MA Inhibitor DM5ITJF RN WO patent application no. 2013,1734,36, Pre-selection of subjects for therapeutic treatment with an hsp90 inhibitor based on hypoxic status. DM5ITJF RU http://worldwide.espacenet.com/publicationDetails/biblio?DB=worldwide.espacenet.com&II=0&ND=3&adjacent=true&locale=en_EP&FT=D&date=20131121&CC=WO&NR=2013173436A1&KC=A1 DMUR1FK DI DMUR1FK DMUR1FK DN Ecalcidene DMUR1FK MI TTK59TV DMUR1FK MN Vitamin D3 receptor (VDR) DMUR1FK MT DTT DMUR1FK MA Modulator DMUR1FK RN Degradation chemistry of a Vitamin D analogue (ecalcidene) investigated by HPLC-MS, HPLC-NMR and chemical derivatization. J Pharm Biomed Anal. 2006 Mar 3;40(4):850-63. DMUR1FK RU https://pubmed.ncbi.nlm.nih.gov/16242878 DMJN7MY DI DMJN7MY DMJN7MY DN ED-110 DMJN7MY MI TTGTQHC DMJN7MY MN DNA topoisomerase I (TOP1) DMJN7MY MT DTT DMJN7MY MA Modulator DMJN7MY RN ED-110, a novel indolocarbazole, prevents the growth of experimental tumors in mice. Jpn J Cancer Res. 1993 May;84(5):574-81. DMJN7MY RU https://www.ncbi.nlm.nih.gov/pubmed/8320174 DMIC460 DI DMIC460 DMIC460 DN Edaglitazone DMIC460 MI TTZMAO3 DMIC460 MN Peroxisome proliferator-activated receptor gamma (PPAR-gamma) DMIC460 MT DTT DMIC460 MA Modulator DMIC460 RN A specific peroxisome proliferator-activated receptor-gamma (PPAR-gamma) ligand, pioglitazone, ameliorates gastric mucosal damage induced by ischemia and reperfusion in rats. Redox Rep. 2002;7(5):343-6. DMIC460 RU https://pubmed.ncbi.nlm.nih.gov/12688526 DM7ROS1 DI DM7ROS1 DM7ROS1 DN Efegatran DM7ROS1 MI TT6L509 DM7ROS1 MN Coagulation factor IIa (F2) DM7ROS1 MT DTT DM7ROS1 MA Inhibitor DM7ROS1 RN Anticoagulation: the present and future. Clin Appl Thromb Hemost. 2001 Jul;7(3):195-204. DM7ROS1 RU https://pubmed.ncbi.nlm.nih.gov/11441979 DMJ0A5U DI DMJ0A5U DMJ0A5U DN EFIPLADIB DMJ0A5U MI TTT1JVS DMJ0A5U MN Cytosolic phospholipase A2 (GIVA cPLA2) DMJ0A5U MT DTT DMJ0A5U MA Inhibitor DMJ0A5U RN Reactions of functionalized sulfonamides: application to lowering the lipophilicity of cytosolic phospholipase A2alpha inhibitors. J Med Chem. 2009 Feb 26;52(4):1156-71. DMJ0A5U RU https://pubmed.ncbi.nlm.nih.gov/19178292 DMYAMP5 DI DMYAMP5 DMYAMP5 DN EHT-1864 DMYAMP5 MI TT2M9CG DMYAMP5 MN Ras-related C3 botulinum toxin substrate 1 (RAC1) DMYAMP5 MT DTT DMYAMP5 MA Inhibitor DMYAMP5 RN Specificity and mechanism of action of EHT 1864, a novel small molecule inhibitor of Rac family small GTPases. J Biol Chem. 2007 Dec 7;282(49):35666-78. DMYAMP5 RU https://pubmed.ncbi.nlm.nih.gov/17932039 DMIP8NB DI DMIP8NB DMIP8NB DN EK-399 DMIP8NB MI TTN4QDT DMIP8NB MN Opioid receptor (OPR) DMIP8NB MT DTT DMIP8NB MA Modulator DMIP8NB RN Evaluation of the discriminative stimulus effect of an enkephalin analog, EK-399, in the rat. Nihon Yakurigaku Zasshi. 1991 Jun;97(6):361-9. DMIP8NB RU https://pubmed.ncbi.nlm.nih.gov/1651892 DMG9R8E DI DMG9R8E DMG9R8E DN EM-2487 DMG9R8E MI TTT3ZC9 DMG9R8E MN Human immunodeficiency virus Tat protein (HIV tat) DMG9R8E MT DTT DMG9R8E MA Inhibitor DMG9R8E RN EM2487, a novel anti-HIV-1 antibiotic, produced by Streptomyces sp. Mer-2487: taxonomy, fermentation, biological properties, isolation and structure elucidation. J Antibiot (Tokyo). 1999 Nov;52(11):971-82. DMG9R8E RU https://pubmed.ncbi.nlm.nih.gov/10656569 DMFZO4Y DI DMFZO4Y DMFZO4Y DN EMBELIN DMFZO4Y MI TTK3WBU DMFZO4Y MN XIAP messenger RNA (XIAP mRNA) DMFZO4Y MT DTT DMFZO4Y MA Inhibitor DMFZO4Y RN Discovery of embelin as a cell-permeable, small-molecular weight inhibitor of XIAP through structure-based computational screening of a traditional... J Med Chem. 2004 May 6;47(10):2430-40. DMFZO4Y RU https://pubmed.ncbi.nlm.nih.gov/15115387 DMAEDQG DI DMAEDQG DMAEDQG DN EMODIN DMAEDQG MI TTER6YH DMAEDQG MN Casein kinase II alpha (CSNK2A1) DMAEDQG MT DTT DMAEDQG MA Inhibitor DMAEDQG RN Structural insight into human CK2alpha in complex with the potent inhibitor ellagic acid. Bioorg Med Chem Lett. 2009 Jun 1;19(11):2920-3. DMAEDQG RU https://pubmed.ncbi.nlm.nih.gov/19414254 DMW210B DI DMW210B DMW210B DN Emopamil DMW210B MI TTYSN63 DMW210B MN 5-HT 2 receptor (5HT2R) DMW210B MT DTT DMW210B MA Modulator DMW210B RN Calcium entry and 5-HT2 receptor blockade in oliguric ischaemic acute renal failure: effects of levemopamil in conscious rats. Br J Pharmacol. 1996 Mar;117(6):1348-54. DMW210B RU https://pubmed.ncbi.nlm.nih.gov/8882635 DMW210B DI DMW210B DMW210B DN Emopamil DMW210B MI TT5HONZ DMW210B MN Calcium channel unspecific (CaC) DMW210B MT DTT DMW210B MA Modulator DMW210B RN Calcium entry and 5-HT2 receptor blockade in oliguric ischaemic acute renal failure: effects of levemopamil in conscious rats. Br J Pharmacol. 1996 Mar;117(6):1348-54. DMW210B RU https://pubmed.ncbi.nlm.nih.gov/8882635 DMW210B DI DMW210B DMW210B DN Emopamil DMW210B MI DE4LYSA DMW210B MN Cytochrome P450 3A4 (CYP3A4) DMW210B MT DME DMW210B MA Metabolism DMW210B RN Integrated analysis on the physicochemical properties of dihydropyridine calcium channel blockers in grapefruit juice interactions. Curr Pharm Biotechnol. 2012 Jul;13(9):1705-17. DMW210B RU https://www.ncbi.nlm.nih.gov/pubmed/?term=22039822 DMJU39N DI DMJU39N DMJU39N DN Endovion DMJU39N MI TTCYAXN DMJU39N MN Chloride channel unspecific (ClC) DMJU39N MT DTT DMJU39N MA Antagonist DMJU39N RN Inhibition of the endogenous volume-regulated anion channel (VRAC) in HEK293 cells by acidic di-aryl-ureas. J Membr Biol. 2003 Nov 15;196(2):83-94. DMJU39N RU https://pubmed.ncbi.nlm.nih.gov/14724745 DMZA5Q4 DI DMZA5Q4 DMZA5Q4 DN EP-2060 DMZA5Q4 MI TTZBFA0 DMZA5Q4 MN Protease unspecific (PRO) DMZA5Q4 MT DTT DMZA5Q4 MA Inducer DMZA5Q4 RN Discovery of 4-aryl-4H-chromenes as potent apoptosis inducers using a cell- and caspase-based Anti-cancer Screening Apoptosis Program (ASAP): SAR studies and the identification of novel vascular disrupting agents. Anticancer Agents Med Chem. 2009 May;9(4):437-56. DMZA5Q4 RU https://pubmed.ncbi.nlm.nih.gov/19442043 DM149HL DI DM149HL DM149HL DN EPD-clofarabine DM149HL MI TTUBNVO DM149HL MN DNA synthesis (DNA synth) DM149HL MT DTT DM149HL MA Inhibitor DM149HL RN 2004 approvals: the demise of the blockbuster. Nat Rev Drug Discov. 2005 Feb;4(2):93-4. DM149HL RU https://pubmed.ncbi.nlm.nih.gov/15756752 DM6IY4M DI DM6IY4M DM6IY4M DN Epiroprim DM6IY4M MI TTV8DM2 DM6IY4M MN Bacterial Dihydrofolate reductase (Bact DHFR) DM6IY4M MT DTT DM6IY4M MA Modulator DM6IY4M RN In vitro activity of epiroprim, a dihydrofolate reductase inhibitor, singly and in combination with brodimoprim and dapsone, against Mycobacterium ... Int J Antimicrob Agents. 1999 Aug;12(4):319-23. DM6IY4M RU https://www.ncbi.nlm.nih.gov/pubmed/10493608 DMWRSXK DI DMWRSXK DMWRSXK DN Epocarbazolin-A DMWRSXK MI TT2J34L DMWRSXK MN Arachidonate 5-lipoxygenase (5-LOX) DMWRSXK MT DTT DMWRSXK MA Inhibitor DMWRSXK RN Epocarbazolins A and B, novel 5-lipoxygenase inhibitors. Taxonomy, fermentation, isolation, structures and biological activities. J Antibiot (Tokyo). 1993 Jan;46(1):25-33. DMWRSXK RU https://pubmed.ncbi.nlm.nih.gov/8436556 DM2NHLW DI DM2NHLW DM2NHLW DN EPTALOPROST DM2NHLW MI TTOFYT1 DM2NHLW MN Prostacyclin receptor (PTGIR) DM2NHLW MT DTT DM2NHLW MA Modulator DM2NHLW RN Bioactivation of eptaloprost in animals and man. Prostaglandins. 1993 Aug;46(2):177-89. DM2NHLW RU https://pubmed.ncbi.nlm.nih.gov/7692471 DMAZVUB DI DMAZVUB DMAZVUB DN ER-34122 DMAZVUB MI TT2J34L DMAZVUB MN Arachidonate 5-lipoxygenase (5-LOX) DMAZVUB MT DTT DMAZVUB MA Modulator DMAZVUB RN Improvement of dissolution and oral absorption of ER-34122, a poorly water-soluble dual 5-lipoxygenase/cyclooxygenase inhibitor with anti-inflammatory activity by preparing solid dispersion. J Pharm Sci. 2002 Jan;91(1):258-66. DMAZVUB RU https://pubmed.ncbi.nlm.nih.gov/11782915 DMYSTAD DI DMYSTAD DMYSTAD DN ER-37328 DMYSTAD MI TT0IHXV DMYSTAD MN DNA topoisomerase II (TOP2) DMYSTAD MT DTT DMYSTAD MA Inhibitor DMYSTAD RN Antitumor activity of ER-37328, a novel carbazole topoisomerase II inhibitor. Mol Cancer Ther. 2002 Jan;1(3):169-75. DMYSTAD RU https://pubmed.ncbi.nlm.nih.gov/12467211 DM08XS2 DI DM08XS2 DM08XS2 DN ERIC-1 DM08XS2 MI TTUBJQ3 DM08XS2 MN Neural cell adhesion molecule (NCAM) DM08XS2 MT DTT DM08XS2 MA Antagonist DM08XS2 RN Monoclonal antibody UJ13A recognizes the neural cell adhesion molecule (NCAM). Int J Cancer. 1989 Dec 15;44(6):1062-8. DM08XS2 RU https://pubmed.ncbi.nlm.nih.gov/2558078 DMJXEV7 DI DMJXEV7 DMJXEV7 DN ERTIPROTAFIB DMJXEV7 MI TTELIN2 DMJXEV7 MN PTPN1 messenger RNA (PTPN1 mRNA) DMJXEV7 MT DTT DMJXEV7 MA Inhibitor DMJXEV7 RN 2-O-carboxymethylpyrogallol derivatives as PTP1B inhibitors with antihyperglycemic activity. Bioorg Med Chem Lett. 2007 Oct 1;17(19):5357-60. DMJXEV7 RU https://pubmed.ncbi.nlm.nih.gov/17728130 DMRP7BX DI DMRP7BX DMRP7BX DN ES-1005 DMRP7BX MI TTB2MXP DMRP7BX MN Angiotensinogenase renin (REN) DMRP7BX MT DTT DMRP7BX MA Inhibitor DMRP7BX RN The effect of the renin inhibitor ES-1005 on the expression of the kidney renin gene in sodium-depleted marmosets. J Hypertens. 1990 Dec;8(12):1143-6. DMRP7BX RU https://pubmed.ncbi.nlm.nih.gov/1962804 DM3BHN1 DI DM3BHN1 DM3BHN1 DN Etomoxir DM3BHN1 MI TTDL0NY DM3BHN1 MN Carnitine O-palmitoyltransferase I (CPT1B) DM3BHN1 MT DTT DM3BHN1 MA Modulator DM3BHN1 RN Etomoxir, a carnitine palmitoyltransferase I inhibitor, protects hearts from fatty acid-induced ischemic injury independent of changes in long chain acylcarnitine. Circ Res. 1988 Dec;63(6):1036-43. DM3BHN1 RU https://pubmed.ncbi.nlm.nih.gov/3197271 DMRQOXG DI DMRQOXG DMRQOXG DN Etrabamine DMRQOXG MI TTEX248 DMRQOXG MN Dopamine D2 receptor (D2R) DMRQOXG MT DTT DMRQOXG MA Modulator DMRQOXG RN WO patent application no. 2009,0568,11, Medicaments. DMRQOXG RU http://worldwide.espacenet.com/publicationDetails/biblio?DB=worldwide.espacenet.com&II=0&ND=3&adjacent=true&locale=en_EP&FT=D&date=20090507&CC=WO&NR=2009056811A2&KC=A2 DMLA3P1 DI DMLA3P1 DMLA3P1 DN EUK-207 DMLA3P1 MI TT6RVLG DMLA3P1 MN Superoxide dismutase Cu-Zn (SOD Cu-Zn) DMLA3P1 MT DTT DMLA3P1 MA Modulator DMLA3P1 RN A synthetic superoxide dismutase/catalase mimetic EUK-207 mitigates radiation dermatitis and promotes wound healing in irradiated rat skin. J Invest Dermatol. 2013 Apr;133(4):1088-96. DMLA3P1 RU https://pubmed.ncbi.nlm.nih.gov/23190879 DM9P4ZN DI DM9P4ZN DM9P4ZN DN EXP-6803 DM9P4ZN MI TTGN1ZA DM9P4ZN MN Angiotensin II receptor (AGTR) DM9P4ZN MT DTT DM9P4ZN MA Modulator DM9P4ZN RN Nonpeptide angiotensin II receptor antagonists. IV. EXP6155 and EXP6803. Hypertension. 1989 May;13(5):489-97. DM9P4ZN RU https://pubmed.ncbi.nlm.nih.gov/2656519 DMR1X2U DI DMR1X2U DMR1X2U DN F-0401 DMR1X2U MI TT27K59 DMR1X2U MN Platelet activating factor (PAF) DMR1X2U MT DTT DMR1X2U MA Inhibitor DMR1X2U RN Protective effects of a novel calcium antagonist with platelet-activating factor-antagonistic action, F-0401, against ischemic brain damage. Arch Int Pharmacodyn Ther. 1994 May-Jun;327(3):266-78. DMR1X2U RU https://pubmed.ncbi.nlm.nih.gov/7848011 DM3786U DI DM3786U DM3786U DN F-12509A DM3786U MI TTOHFIY DM3786U MN Sphingosine kinase 1 (SPHK1) DM3786U MT DTT DM3786U MA Inhibitor DM3786U RN F-12509A, a new sphingosine kinase inhibitor, produced by a discomycete. J Antibiot (Tokyo). 2000 May;53(5):459-66. DM3786U RU https://pubmed.ncbi.nlm.nih.gov/10908108 DM23OHW DI DM23OHW DM23OHW DN F-12682 DM23OHW MI TTK8CXU DM23OHW MN 5-HT 1B receptor (HTR1B) DM23OHW MT DTT DM23OHW MA Antagonist DM23OHW RN Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800010898) DM23OHW RU http://adisinsight.springer.com/drugs/800010898 DMGH3QD DI DMGH3QD DMGH3QD DN F-14413 DMGH3QD MI TT2NUT5 DMGH3QD MN Adrenergic receptor alpha-2C (ADRA2C) DMGH3QD MT DTT DMGH3QD MA Antagonist DMGH3QD RN Activation of noradrenergic transmission by alpha2-adrenoceptor antagonists counteracts deafferentation-induced neuronal death and cell proliferation in the adult mouse olfactory bulb. Exp Neurol. 2005 Aug;194(2):444-56. DMGH3QD RU https://pubmed.ncbi.nlm.nih.gov/16022870 DMVWZN1 DI DMVWZN1 DMVWZN1 DN F-200 DMVWZN1 MI TTH4QIS DMVWZN1 MN Integrin alpha-5/beta-1 (ITGA5/B1) DMVWZN1 MT DTT DMVWZN1 MA Inhibitor DMVWZN1 RN US patent application no. 8,541,413, Sustained release eye drop formulations. DMVWZN1 RU http://www.google.com/patents/US8541413 DMXB8SE DI DMXB8SE DMXB8SE DN F-3796 DMXB8SE MI TT1RS9F DMXB8SE MN Acetylcholinesterase (AChE) DMXB8SE MT DTT DMXB8SE MA Inhibitor DMXB8SE RN Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800004498) DMXB8SE RU http://adisinsight.springer.com/drugs/800004498 DMJ3MAZ DI DMJ3MAZ DMJ3MAZ DN F-992 DMJ3MAZ MI TTYCILE DMJ3MAZ MN Vasopressin receptor (VR) DMJ3MAZ MT DTT DMJ3MAZ MA Agonist DMJ3MAZ RN A site of tyrosine phosphorylation in the C terminus of the epidermal growth factor receptor is required to activate phospholipase C.. Mol Cell Biol. 1992 January; 12(1): 128-135. DMJ3MAZ RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC364076/ DME694O DI DME694O DME694O DN Fananserin DME694O MI TTJQOD7 DME694O MN 5-HT 2A receptor (HTR2A) DME694O MT DTT DME694O MA Antagonist DME694O RN Autoradiographic studies of RP 62203, a potent 5-HT2 receptor antagonist. Pharmacological characterization of [3H]RP 62203 binding in the rat brain. Eur J Pharmacol. 1993 Mar 16;233(1):37-45. DME694O RU https://pubmed.ncbi.nlm.nih.gov/8472747 DMR3ZWA DI DMR3ZWA DMR3ZWA DN FCE-25876 DMR3ZWA MI TTWT5K7 DMR3ZWA MN 5-HT 1 receptor (5HT1R) DMR3ZWA MT DTT DMR3ZWA MA Modulator DMR3ZWA RN Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800001389) DMR3ZWA RU http://adisinsight.springer.com/drugs/800001389 DMJX1IB DI DMJX1IB DMJX1IB DN Fedotozine DMJX1IB MI TTQW87Y DMJX1IB MN Opioid receptor kappa (OPRK1) DMJX1IB MT DTT DMJX1IB MA Agonist DMJX1IB RN Irritable bowel syndrome neuropharmacology. A review of approved and investigational compounds. J Clin Gastroenterol. 2002 Jul;35(1 Suppl):S58-67. DMJX1IB RU https://pubmed.ncbi.nlm.nih.gov/12184141 DMJ35RC DI DMJ35RC DMJ35RC DN FH-510 DMJ35RC MI TT5TPI6 DMJ35RC MN Opioid receptor sigma 1 (OPRS1) DMJ35RC MT DTT DMJ35RC MA Modulator DMJ35RC RN FH-510, a potent and selective ligand for rat brain sigma recognition sites. Eur J Pharmacol. 1993 Jul 6;238(1):89-92. DMJ35RC RU https://pubmed.ncbi.nlm.nih.gov/8104803 DMIGXQF DI DMIGXQF DMIGXQF DN FK-355 DMIGXQF MI TTZPO1L DMIGXQF MN Substance-P receptor (TACR1) DMIGXQF MT DTT DMIGXQF MA Antagonist DMIGXQF RN FK 224, a novel cyclopeptide substance P antagonist with NK1 and NK2 receptor selectivity. J Pharmacol Exp Ther. 1992 Jul;262(1):398-402. DMIGXQF RU https://pubmed.ncbi.nlm.nih.gov/1378096 DMDVAI5 DI DMDVAI5 DMDVAI5 DN Florifenine DMDVAI5 MI TTK0943 DMDVAI5 MN Prostaglandin G/H synthase (COX) DMDVAI5 MT DTT DMDVAI5 MA Modulator DMDVAI5 RN A study of the novel anti-inflammatory agent florifenine topical anti-inflammatory activity and influence on arachidonic acid metabolism and neutrophil functions. Naunyn Schmiedebergs Arch Pharmacol.1995 Mar;351(3):298-304. DMDVAI5 RU https://pubmed.ncbi.nlm.nih.gov/7609784 DMY89KQ DI DMY89KQ DMY89KQ DN Flosequinan DMY89KQ MI DE4LYSA DMY89KQ MN Cytochrome P450 3A4 (CYP3A4) DMY89KQ MT DME DMY89KQ MA Metabolism DMY89KQ RN Cytochrome P450 responsible for the stereoselective S-oxidation of flosequinan in hepatic microsomes from rats and humans. Drug Metab Dispos. 1997 Jun;25(6):716-24. DMY89KQ RU https://www.ncbi.nlm.nih.gov/pubmed/?term=9193873 DM6OIJ1 DI DM6OIJ1 DM6OIJ1 DN Flosulide DM6OIJ1 MI TTVKILB DM6OIJ1 MN Prostaglandin G/H synthase 2 (COX-2) DM6OIJ1 MT DTT DM6OIJ1 MA Modulator DM6OIJ1 RN Effect of flosulide, a selective cyclooxygenase 2 inhibitor, on passive heymann nephritis in the rat. Kidney Int. 1999 Nov;56(5):1770-8. DM6OIJ1 RU https://pubmed.ncbi.nlm.nih.gov/10571785 DM7JT3D DI DM7JT3D DM7JT3D DN Fluoratec DM7JT3D MI TTVBI8W DM7JT3D MN Dopamine transporter (DAT) DM7JT3D MT DTT DM7JT3D MA Modulator DM7JT3D RN Technepine: a high-affinity 99m-technetium probe to label the dopamine transporter in brain by SPECT imaging. Synapse. 1996 Mar;22(3):239-46. DM7JT3D RU https://pubmed.ncbi.nlm.nih.gov/9132992 DMSYLIF DI DMSYLIF DMSYLIF DN Fosfluridine tidoxil DMSYLIF MI TTU6BFZ DMSYLIF MN Candida Thymidylate synthase (Candi TMP1) DMSYLIF MT DTT DMSYLIF MA Inhibitor DMSYLIF RN Selective protection by uridine of growth inhibition by 5-fluorouracil (5FU) mediated by 5FU incorporation into RNA, but not the thymidylate synthase mediated growth inhibition by 5FU-leucovorin. Nucleosides Nucleotides Nucleic Acids. 2008 Jun;27(6):733-9. DMSYLIF RU https://pubmed.ncbi.nlm.nih.gov/18600533 DMF1CDK DI DMF1CDK DMF1CDK DN FPL-55712 DMF1CDK MI TTGKOY9 DMF1CDK MN Leukotriene CysLT1 receptor (CYSLTR1) DMF1CDK MT DTT DMF1CDK MA Modulator DMF1CDK RN Effect of the leukotriene receptor antagonists FPL 55712, LY 163443, and MK-571 on the elimination of cysteinyl leukotrienes in the rat. Br J Pharmacol. 1991 Apr;102(4):865-70. DMF1CDK RU https://pubmed.ncbi.nlm.nih.gov/1855116 DMF1CDK DI DMF1CDK DMF1CDK DN FPL-55712 DMF1CDK MI TT0PZR5 DMF1CDK MN Leukotriene CysLT2 receptor (CYSLTR2) DMF1CDK MT DTT DMF1CDK MA Modulator DMF1CDK RN Effect of the leukotriene receptor antagonists FPL 55712, LY 163443, and MK-571 on the elimination of cysteinyl leukotrienes in the rat. Br J Pharmacol. 1991 Apr;102(4):865-70. DMF1CDK RU https://pubmed.ncbi.nlm.nih.gov/1855116 DMCAZPR DI DMCAZPR DMCAZPR DN FR-113680 DMCAZPR MI TTZPO1L DMCAZPR MN Substance-P receptor (TACR1) DMCAZPR MT DTT DMCAZPR MA Inhibitor DMCAZPR RN FR 113680: a novel tripeptide substance P antagonist with NK1 receptor selectivity. Br J Pharmacol. 1992 May;106(1):123-6. DMCAZPR RU https://pubmed.ncbi.nlm.nih.gov/1380378 DMY2IB8 DI DMY2IB8 DMY2IB8 DN FR-115427 DMY2IB8 MI TT9IK2Z DMY2IB8 MN N-methyl-D-aspartate receptor (NMDAR) DMY2IB8 MT DTT DMY2IB8 MA Modulator DMY2IB8 RN Non-competitive NMDA antagonists, FR115427 and MK801, enhance neuronal survival in primary culture. Neurosci Lett. 1995 Feb 9;185(2):107-10. DMY2IB8 RU https://pubmed.ncbi.nlm.nih.gov/7746498 DMNRUGA DI DMNRUGA DMNRUGA DN FR-121196 DMNRUGA MI TTIND6G DMNRUGA MN Somatostatin receptor type 1 (SSTR1) DMNRUGA MT DTT DMNRUGA MA Modulator DMNRUGA RN Nat Rev Drug Discov. 2013 Feb;12(2):87-90. DMNRUGA RU https://pubmed.ncbi.nlm.nih.gov/23370234 DMNRUGA DI DMNRUGA DMNRUGA DN FR-121196 DMNRUGA MI TTZ6T9E DMNRUGA MN Somatostatin receptor type 2 (SSTR2) DMNRUGA MT DTT DMNRUGA MA Modulator DMNRUGA RN Role of somatostatin in the augmentation of hippocampal long-term potentiation by FR121196, a putative cognitive enhancer. Eur J Pharmacol. 1993 Sep 7;241(1):27-34. DMNRUGA RU https://pubmed.ncbi.nlm.nih.gov/7901036 DMNRUGA DI DMNRUGA DMNRUGA DN FR-121196 DMNRUGA MI TTJX3UE DMNRUGA MN Somatostatin receptor type 3 (SSTR3) DMNRUGA MT DTT DMNRUGA MA Modulator DMNRUGA RN Nat Rev Drug Discov. 2013 Feb;12(2):87-90. DMNRUGA RU https://pubmed.ncbi.nlm.nih.gov/23370234 DMNRUGA DI DMNRUGA DMNRUGA DN FR-121196 DMNRUGA MI TTAE1BR DMNRUGA MN Somatostatin receptor type 4 (SSTR4) DMNRUGA MT DTT DMNRUGA MA Modulator DMNRUGA RN Role of somatostatin in the augmentation of hippocampal long-term potentiation by FR121196, a putative cognitive enhancer. Eur J Pharmacol. 1993 Sep 7;241(1):27-34. DMNRUGA RU https://pubmed.ncbi.nlm.nih.gov/7901036 DMNRUGA DI DMNRUGA DMNRUGA DN FR-121196 DMNRUGA MI TT2BC4G DMNRUGA MN Somatostatin receptor type 5 (SSTR5) DMNRUGA MT DTT DMNRUGA MA Modulator DMNRUGA RN Role of somatostatin in the augmentation of hippocampal long-term potentiation by FR121196, a putative cognitive enhancer. Eur J Pharmacol. 1993 Sep 7;241(1):27-34. DMNRUGA RU https://pubmed.ncbi.nlm.nih.gov/7901036 DM0582D DI DM0582D DM0582D DN FR-123826 DM0582D MI TTVKILB DM0582D MN Prostaglandin G/H synthase 2 (COX-2) DM0582D MT DTT DM0582D MA Inhibitor DM0582D RN Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800007983) DM0582D RU http://adisinsight.springer.com/drugs/800007983 DMMOBHW DI DMMOBHW DMMOBHW DN FR-128998 DMMOBHW MI TTQL5VC DMMOBHW MN Platelet-activating factor receptor (PTAFR) DMMOBHW MT DTT DMMOBHW MA Modulator DMMOBHW RN Effect of FR128998, a novel PAF receptor antagonist, on endotoxin-induced disseminated intravascular coagulation. Eur J Pharmacol. 1994 Jun 13;258(3):239-46. DMMOBHW RU https://pubmed.ncbi.nlm.nih.gov/8088357 DM9V6AU DI DM9V6AU DM9V6AU DN FR-129169 DM9V6AU MI TTMF541 DM9V6AU MN Liver carboxylesterase (CES1) DM9V6AU MT DTT DM9V6AU MA Modulator DM9V6AU RN Plasma cholesterol reducing effect of FR129169, a novel acyl-CoA:cholesterol acyltransferase inhibitor, in the rat. Jpn J Pharmacol. 1996 Jan;70(1):35-41. DM9V6AU RU https://pubmed.ncbi.nlm.nih.gov/8822087 DMXWL0N DI DMXWL0N DMXWL0N DN FR-133605 DMXWL0N MI TT51DEV DMXWL0N MN Interleukin 1 receptor type 2 (IL1R2) DMXWL0N MT DTT DMXWL0N MA Modulator DMXWL0N RN Effect of FR133605, a novel cytokine suppressive agent, on bone and cartilage destruction in adjuvant arthritic rats. J Rheumatol. 1996 Oct;23(10):1778-83. DMXWL0N RU https://pubmed.ncbi.nlm.nih.gov/8895158 DMXWL0N DI DMXWL0N DMXWL0N DN FR-133605 DMXWL0N MI TTF8CQI DMXWL0N MN Tumor necrosis factor (TNF) DMXWL0N MT DTT DMXWL0N MA Modulator DMXWL0N RN Effect of FR133605, a novel cytokine suppressive agent, on bone and cartilage destruction in adjuvant arthritic rats. J Rheumatol. 1996 Oct;23(10):1778-83. DMXWL0N RU https://pubmed.ncbi.nlm.nih.gov/8895158 DMHV43M DI DMHV43M DMHV43M DN FR-145237 DMHV43M MI TTMF541 DMHV43M MN Liver carboxylesterase (CES1) DMHV43M MT DTT DMHV43M MA Modulator DMHV43M RN Effect of FR145237, a novel ACAT inhibitor, on atherogenesis in cholesterol-fed and WHHL rabbits. Evidence for a direct effect on the arterial wall. Biochim Biophys Acta. 1995 Dec 7;1259(3):254-60. DMHV43M RU https://pubmed.ncbi.nlm.nih.gov/8541332 DMBOFSQ DI DMBOFSQ DMBOFSQ DN FR-149581 DMBOFSQ MI TTGN1ZA DMBOFSQ MN Angiotensin II receptor (AGTR) DMBOFSQ MT DTT DMBOFSQ MA Antagonist DMBOFSQ RN US patent application no. 2003,0087,306, Methods for identifying novel multimeric agents that modulate receptors. DMBOFSQ RU http://www.google.com/patents/US20030087306 DMOEYX2 DI DMOEYX2 DMOEYX2 DN FR-152558 DMOEYX2 MI TT1RS9F DMOEYX2 MN Acetylcholinesterase (AChE) DMOEYX2 MT DTT DMOEYX2 MA Inhibitor DMOEYX2 RN Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800006757) DMOEYX2 RU http://adisinsight.springer.com/drugs/800006757 DMIQB9E DI DMIQB9E DMIQB9E DN FR-171113 DMIQB9E MI TTL935N DMIQB9E MN Proteinase activated receptor 1 (F2R) DMIQB9E MT DTT DMIQB9E MA Modulator DMIQB9E RN In vitro antiplatelet profile of FR171113, a novel non-peptide thrombin receptor antagonist. Eur J Pharmacol. 1999 Nov 19;384(2-3):197-202. DMIQB9E RU https://pubmed.ncbi.nlm.nih.gov/10611442 DMY1LRI DI DMY1LRI DMY1LRI DN FR-172357 DMY1LRI MI TTGY8IW DMY1LRI MN B2 bradykinin receptor (BDKRB2) DMY1LRI MT DTT DMY1LRI MA Antagonist DMY1LRI RN Characterization of FR 172357, a new non-peptide bradykinin B(2) receptor antagonist, in human, pig and rabbit preparations. Eur J Pharmacol. 1999 Dec 10;386(1):25-31. DMY1LRI RU https://pubmed.ncbi.nlm.nih.gov/10611460 DM37OS4 DI DM37OS4 DM37OS4 DN FR-173657 DM37OS4 MI TTGY8IW DM37OS4 MN B2 bradykinin receptor (BDKRB2) DM37OS4 MT DTT DM37OS4 MA Inhibitor DM37OS4 RN Novel small molecule bradykinin B2 receptor antagonists. J Med Chem. 2009 Jul 23;52(14):4370-9. DM37OS4 RU https://pubmed.ncbi.nlm.nih.gov/19552431 DMCQHG4 DI DMCQHG4 DMCQHG4 DN FR-183998 DMCQHG4 MI TT70SZ3 DMCQHG4 MN Sodium/hydrogen exchanger (SLC) DMCQHG4 MT DTT DMCQHG4 MA Modulator DMCQHG4 RN Protective effect of FR183998, a Na+/H+ exchanger inhibitor, and its inhibition of iNOS induction in hepatic ischemia-reperfusion injury in rats. Shock. 2008 Sep;30(3):311-7. DMCQHG4 RU https://pubmed.ncbi.nlm.nih.gov/18277953 DMNACIV DI DMNACIV DMNACIV DN FR-194738 DMNACIV MI TTE14XG DMNACIV MN Squalene monooxygenase (SQLE) DMNACIV MT DTT DMNACIV MA Modulator DMNACIV RN Synthesis and biological activity of a novel squalene epoxidase inhibitor, FR194738. Bioorg Med Chem Lett. 2004 Feb 9;14(3):633-7. DMNACIV RU https://pubmed.ncbi.nlm.nih.gov/14741258 DMLG426 DI DMLG426 DMLG426 DN FR-208419 DMLG426 MI TTCG0AL DMLG426 MN Cholecystokinin receptor type A (CCKAR) DMLG426 MT DTT DMLG426 MA Modulator DMLG426 RN Dual CCK-A and CCK-B receptor antagonists (II). Preparation and structure activity relationships of 5-alkyl-9-methyl-1,4-benzodiazepines and discovery of FR208419. Chem Pharm Bull (Tokyo). 2000 Jan;48(1):1-15. DMLG426 RU https://pubmed.ncbi.nlm.nih.gov/10705468 DMLG426 DI DMLG426 DMLG426 DN FR-208419 DMLG426 MI TTVFO0U DMLG426 MN Gastrin/cholecystokinin type B receptor (CCKBR) DMLG426 MT DTT DMLG426 MA Modulator DMLG426 RN Dual CCK-A and CCK-B receptor antagonists (II). Preparation and structure activity relationships of 5-alkyl-9-methyl-1,4-benzodiazepines and discovery of FR208419. Chem Pharm Bull (Tokyo). 2000 Jan;48(1):1-15. DMLG426 RU https://pubmed.ncbi.nlm.nih.gov/10705468 DMT6R8I DI DMT6R8I DMT6R8I DN FR-229934 DMT6R8I MI TTJ0IQB DMT6R8I MN Phosphodiesterase 5A (PDE5A) DMT6R8I MT DTT DMT6R8I MA Inhibitor DMT6R8I RN Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800014897) DMT6R8I RU http://adisinsight.springer.com/drugs/800014897 DMJS9YB DI DMJS9YB DMJS9YB DN FR-62765 DMJS9YB MI TTFBNVI DMJS9YB MN Aldose reductase (AKR1B1) DMJS9YB MT DTT DMJS9YB MA Modulator DMJS9YB RN Studies on WF-3681, a novel aldose reductase inhibitor. IV. Effect of FR-62765, a derivative of WF-3681, on the diabetic neuropathy in rats. J Antibiot (Tokyo). 1991 Apr;44(4):441-4. DMJS9YB RU https://pubmed.ncbi.nlm.nih.gov/1903376 DM7WGXS DI DM7WGXS DM7WGXS DN FR-76830 DM7WGXS MI TT5WKM8 DM7WGXS MN ATP phosphatase (ATPase) DM7WGXS MT DTT DM7WGXS MA Modulator DM7WGXS RN On the mode of cardioprotection produced by a new bradycardic agent, FR 76830, during ischaemia and after reperfusion in the isolated perfused rat heart: a 31P-NMR study. Cardiovasc Res. 1990 Dec;24(12):1008-12. DM7WGXS RU https://pubmed.ncbi.nlm.nih.gov/2151429 DM6PFVD DI DM6PFVD DM6PFVD DN FR-901277 DM6PFVD MI TTPLTSQ DM6PFVD MN Neutrophil elastase (NE) DM6PFVD MT DTT DM6PFVD MA Inhibitor DM6PFVD RN Resisting degradation by human elastase: commonality of design features shared by 'canonical' plant and bacterial macrocyclic protease inhibitor sc... Bioorg Med Chem. 2007 Jul 1;15(13):4618-28. DM6PFVD RU https://pubmed.ncbi.nlm.nih.gov/17470393 DM2FNPO DI DM2FNPO DM2FNPO DN FR-901451 DM2FNPO MI TTPLTSQ DM2FNPO MN Neutrophil elastase (NE) DM2FNPO MT DTT DM2FNPO MA Inhibitor DM2FNPO RN Resisting degradation by human elastase: commonality of design features shared by 'canonical' plant and bacterial macrocyclic protease inhibitor sc... Bioorg Med Chem. 2007 Jul 1;15(13):4618-28. DM2FNPO RU https://pubmed.ncbi.nlm.nih.gov/17470393 DMN4E5H DI DMN4E5H DMN4E5H DN Fradafiban DMN4E5H MI TT38RM1 DMN4E5H MN Glycoprotein IIb/IIIa receptor (GPIIb/IIIa) DMN4E5H MT DTT DMN4E5H MA Modulator DMN4E5H RN Profound and sustained inhibition of platelet aggregation by Fradafiban, a nonpeptide platelet glycoprotein IIb/IIIa antagonist, and its orally active prodrug, Lefradafiban, in men. Circulation. 1997Aug 19;96(4):1130-8. DMN4E5H RU https://pubmed.ncbi.nlm.nih.gov/9286940 DMC5O3X DI DMC5O3X DMC5O3X DN FRG-8701 DMC5O3X MI TTQHJ1K DMC5O3X MN Histamine H2 receptor (H2R) DMC5O3X MT DTT DMC5O3X MA Modulator DMC5O3X RN Effects of FRG-8701 on gastric acid secretion, gastric mucosal lesions by necrotizing agents and experimental gastric or duodenal ulcer in rats. Jpn J Pharmacol. 1990 Nov;54(3):277-85. DMC5O3X RU https://pubmed.ncbi.nlm.nih.gov/1982548 DMI1Y92 DI DMI1Y92 DMI1Y92 DN FUSIDIENOL DMI1Y92 MI TT7WZIJ DMI1Y92 MN CAAX farnesyltransferase beta (FNTB) DMI1Y92 MT DTT DMI1Y92 MA Inhibitor DMI1Y92 RN Modeling of binding modes and inhibition mechanism of some natural ligands of farnesyl transferase using molecular docking. J Med Chem. 2002 Mar 28;45(7):1460-5. DMI1Y92 RU https://pubmed.ncbi.nlm.nih.gov/11906287 DMZXA0W DI DMZXA0W DMZXA0W DN Garenoxacin DMZXA0W MI TT0IHXV DMZXA0W MN DNA topoisomerase II (TOP2) DMZXA0W MT DTT DMZXA0W MA Inhibitor DMZXA0W RN The inhibition and selectivity of bacterial topoisomerases by BMS-284756 and its analogues. J Antimicrob Chemother. 2001 Aug;48(2):195-201. DMZXA0W RU https://pubmed.ncbi.nlm.nih.gov/11481288 DMOAURL DI DMOAURL DMOAURL DN GDC-0834 DMOAURL MI TTGM6VW DMOAURL MN Tyrosine-protein kinase BTK (ATK) DMOAURL MT DTT DMOAURL MA Inhibitor DMOAURL RN Antiarthritis effect of a novel Bruton's tyrosine kinase (BTK) inhibitor in rat collagen-induced arthritis and mechanism-based pharmacokinetic/pharmacodynamic modeling: relationships between inhibition of BTK phosphorylation and efficacy. J Pharmacol Exp Ther. 2011 Jul;338(1):154-63. DMOAURL RU https://pubmed.ncbi.nlm.nih.gov/21521773 DMGM3VP DI DMGM3VP DMGM3VP DN GE-20372A DMGM3VP MI TT5FNQT DMGM3VP MN Human immunodeficiency virus Protease (HIV PR) DMGM3VP MT DTT DMGM3VP MA Inhibitor DMGM3VP RN US patent application no. 2008,0161,324, Compositions and methods for treatment of viral diseases. DMGM3VP RU http://www.google.com/patents/US20080161324 DMZF9CY DI DMZF9CY DMZF9CY DN GE-68 DMZF9CY MI TTRK8B9 DMZF9CY MN Sodium channel unspecific (NaC) DMZF9CY MT DTT DMZF9CY MA Modulator DMZF9CY RN Electrophysiological properties of the propafenone-analogue GE 68 (1-[3-(phenylethyl)-2-benzofuryl]-2-(propylamino)-ethanol) in isolated preparations and ventricular myocytes of guinea-pig hearts. Naunyn Schmiedebergs Arch Pharmacol. 1997 Feb;355(2):230-8. DMZF9CY RU https://pubmed.ncbi.nlm.nih.gov/9050017 DMVAM18 DI DMVAM18 DMVAM18 DN Gene therapy, IFN-alpha DMVAM18 MI TT95SOA DMVAM18 MN Interferon alpha (IFNA) DMVAM18 MT DTT DMVAM18 MA Modulator DMVAM18 RN 2007 FDA drug approvals: a year of flux. Nat Rev Drug Discov. 2008 Feb;7(2):107-9. DMVAM18 RU https://pubmed.ncbi.nlm.nih.gov/18246607 DM6JNV3 DI DM6JNV3 DM6JNV3 DN Genevx DM6JNV3 MI TTVJ1D8 DM6JNV3 MN Vascular endothelial growth factor receptor (VEGFR) DM6JNV3 MT DTT DM6JNV3 MA Modulator DM6JNV3 RN Vascular Endothelial Growth Factor Gene Therapy Increases Survival, Promotes Lung Angiogenesis, and Prevents Alveolar Damage in Hyperoxia-Induced Lung Injury. Circulation. 2005; 112: 2477-2486. DM6JNV3 RU http://circ.ahajournals.org/content/112/16/2477.figures-only?sid=d5a20876-08aa-4d32-9f57-765c26558bd6 DMGX5Q0 DI DMGX5Q0 DMGX5Q0 DN Gepirone DMGX5Q0 MI TTSQIFT DMGX5Q0 MN 5-HT 1A receptor (HTR1A) DMGX5Q0 MT DTT DMGX5Q0 MA Agonist DMGX5Q0 RN Novel drugs and therapeutic targets for severe mood disorders. Neuropsychopharmacology. 2008 Aug;33(9):2080-92. DMGX5Q0 RU https://pubmed.ncbi.nlm.nih.gov/18172433 DMGX5Q0 DI DMGX5Q0 DMGX5Q0 DN Gepirone DMGX5Q0 MI DECB0K3 DMGX5Q0 MN Cytochrome P450 2D6 (CYP2D6) DMGX5Q0 MT DME DMGX5Q0 MA Metabolism DMGX5Q0 RN Metabolism of the newest antidepressants: comparisons with related predecessors. IDrugs. 2004 Feb;7(2):143-50. DMGX5Q0 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=15057659 DMGX5Q0 DI DMGX5Q0 DMGX5Q0 DN Gepirone DMGX5Q0 MI DE4LYSA DMGX5Q0 MN Cytochrome P450 3A4 (CYP3A4) DMGX5Q0 MT DME DMGX5Q0 MA Metabolism DMGX5Q0 RN Metabolism of the newest antidepressants: comparisons with related predecessors. IDrugs. 2004 Feb;7(2):143-50. DMGX5Q0 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=15057659 DM1CG0J DI DM1CG0J DM1CG0J DN GGTI-298 DM1CG0J MI TTX20QP DM1CG0J MN Geranylgeranyl transferase I (GGTase-I) DM1CG0J MT DTT DM1CG0J MA Inhibitor DM1CG0J RN The geranylgeranyltransferase-I inhibitor GGTI-298 arrests human tumor cells in G0/G1 and induces p21(WAF1/CIP1/SDI1) in a p53-independent manner. J Biol Chem. 1997 Oct 24;272(43):27224-9. DM1CG0J RU https://pubmed.ncbi.nlm.nih.gov/9341167 DMXVP13 DI DMXVP13 DMXVP13 DN GI-129471 DMXVP13 MI TT1GHVO DMXVP13 MN Matrix metalloproteinase (MMP) DMXVP13 MT DTT DMXVP13 MA Modulator DMXVP13 RN Stimulation of matrix metalloproteinase-9 expression in human fibrosarcoma cells by synthetic matrix metalloproteinase inhibitors. Exp Cell Res. 2002 Apr 15;275(1):110-21. DMXVP13 RU https://pubmed.ncbi.nlm.nih.gov/11925109 DM6HZU1 DI DM6HZU1 DM6HZU1 DN GI-197111 DM6HZU1 MI TT2A0DR DM6HZU1 MN Oxo-5-alpha-steroid 4-dehydrogenase (SRD5A) DM6HZU1 MT DTT DM6HZU1 MA Modulator DM6HZU1 RN Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800008867) DM6HZU1 RU http://adisinsight.springer.com/drugs/800008867 DMT6J1E DI DMT6J1E DMT6J1E DN GI-248573 DMT6J1E MI TTCG0AL DMT6J1E MN Cholecystokinin receptor type A (CCKAR) DMT6J1E MT DTT DMT6J1E MA Modulator DMT6J1E RN US patent application no. 8,748,419, Antagonists. DMT6J1E RU http://www.google.com.ar/Patents/US8748419 DM3KN2Q DI DM3KN2Q DM3KN2Q DN GI-270384X DM3KN2Q MI TTAU4D6 DM3KN2Q MN E-selectin (SELE) DM3KN2Q MT DTT DM3KN2Q MA Modulator DM3KN2Q RN Inhibition of endothelial cell adhesion molecule expression improves colonic hyperalgaesia. Neurogastroenterol Motil. 2009 Feb;21(2):189-96. DM3KN2Q RU https://pubmed.ncbi.nlm.nih.gov/19126181 DM3KN2Q DI DM3KN2Q DM3KN2Q DN GI-270384X DM3KN2Q MI TTCT6F7 DM3KN2Q MN Intercellular adhesion molecule ICAM-1 (ICAM1) DM3KN2Q MT DTT DM3KN2Q MA Modulator DM3KN2Q RN Inhibition of endothelial cell adhesion molecule expression improves colonic hyperalgaesia. Neurogastroenterol Motil. 2009 Feb;21(2):189-96. DM3KN2Q RU https://pubmed.ncbi.nlm.nih.gov/19126181 DMX0N9P DI DMX0N9P DMX0N9P DN Ginkgolide B (GKB) DMX0N9P MI TTPTXIN DMX0N9P MN Translocator protein (TSPO) DMX0N9P MT DTT DMX0N9P MA Suppressor DMX0N9P RN Drug-induced inhibition of the peripheral-type benzodiazepine receptor expression and cell proliferation in human breast cancer cells. Anticancer Res. 2000 Sep-Oct;20(5A):2835-47. DMX0N9P RU https://pubmed.ncbi.nlm.nih.gov/11062691 DMLIM7B DI DMLIM7B DMLIM7B DN GINKOLIDE B DMLIM7B MI TTZ8EM9 DMLIM7B MN Glycine receptor (GlyR) DMLIM7B MT DTT DMLIM7B MA Inhibitor DMLIM7B RN Probing the pharmacophore of ginkgolides as glycine receptor antagonists. J Med Chem. 2007 Apr 5;50(7):1610-7. DMLIM7B RU https://pubmed.ncbi.nlm.nih.gov/17352465 DMLIM7B DI DMLIM7B DMLIM7B DN GINKOLIDE B DMLIM7B MI TTF45NW DMLIM7B MN Strychnine-binding glycine receptor (GLRA1) DMLIM7B MT DTT DMLIM7B MA Inhibitor DMLIM7B RN Probing the pharmacophore of ginkgolides as glycine receptor antagonists. J Med Chem. 2007 Apr 5;50(7):1610-7. DMLIM7B RU https://pubmed.ncbi.nlm.nih.gov/17352465 DMSVMF2 DI DMSVMF2 DMSVMF2 DN Girisopam DMSVMF2 MI TTEX6LM DMSVMF2 MN GABA(A) receptor gamma-3 (GABRG3) DMSVMF2 MT DTT DMSVMF2 MA Modulator DMSVMF2 RN [(3)H]-girisopam, a novel selective benzodiazepine for the 2, 3-benzodiazepine binding site. Brain Res Brain Res Protoc. 1999 Jul;4(2):230-5. DMSVMF2 RU https://www.ncbi.nlm.nih.gov/pubmed/10446419 DM4RKDU DI DM4RKDU DM4RKDU DN GK-128 DM4RKDU MI TTNXLKE DM4RKDU MN 5-HT 3 receptor (5HT3R) DM4RKDU MT DTT DM4RKDU MA Modulator DM4RKDU RN Effect of a novel 5-hydroxytryptamine3 (5-HT3) receptor antagonist, GK-128, on 5-HT3 receptors mediating contractions and relaxations in guinea-pig distal colon. Gen Pharmacol. 1997 Sep;29(3):353-9. DM4RKDU RU https://pubmed.ncbi.nlm.nih.gov/9378239 DMONQYZ DI DMONQYZ DMONQYZ DN Gliotoxin DMONQYZ MI TTSXVID DMONQYZ MN Nuclear factor NF-kappa-B (NFKB) DMONQYZ MT DTT DMONQYZ MA Inhibitor DMONQYZ RN Gliotoxin inhibits neointimal hyperplasia after vascular injury in rats. J Vasc Res. 2009;46(4):278-89. DMONQYZ RU https://pubmed.ncbi.nlm.nih.gov/19033690 DM0IKB4 DI DM0IKB4 DM0IKB4 DN GLY-515n DM0IKB4 MI TTQG4NR DM0IKB4 MN Erythropoietin (EPO) DM0IKB4 MT DTT DM0IKB4 MA Modulator DM0IKB4 RN Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800027536) DM0IKB4 RU http://adisinsight.springer.com/drugs/800027536 DMEVIP9 DI DMEVIP9 DMEVIP9 DN GM-7050 DMEVIP9 MI TTD26RC DMEVIP9 MN Cell adhesion molecule (CADM) DMEVIP9 MT DTT DMEVIP9 MA Modulator DMEVIP9 RN US patent application no. 6,673,908, Tumor necrosis factor receptor 2. DMEVIP9 RU http://www.google.com/patents/US6673908 DMT1RH6 DI DMT1RH6 DMT1RH6 DN GMC-283 DMT1RH6 MI TTJQOD7 DMT1RH6 MN 5-HT 2A receptor (HTR2A) DMT1RH6 MT DTT DMT1RH6 MA Antagonist DMT1RH6 RN The pipeline and future of drug development in schizophrenia. Mol Psychiatry. 2007 Oct;12(10):904-22. DMT1RH6 RU https://pubmed.ncbi.nlm.nih.gov/17667958 DMT1RH6 DI DMT1RH6 DMT1RH6 DN GMC-283 DMT1RH6 MI TTEX248 DMT1RH6 MN Dopamine D2 receptor (D2R) DMT1RH6 MT DTT DMT1RH6 MA Antagonist DMT1RH6 RN The pipeline and future of drug development in schizophrenia. Mol Psychiatry. 2007 Oct;12(10):904-22. DMT1RH6 RU https://pubmed.ncbi.nlm.nih.gov/17667958 DMT1RH6 DI DMT1RH6 DMT1RH6 DN GMC-283 DMT1RH6 MI TTS2PH3 DMT1RH6 MN Dopamine D5 receptor (D5R) DMT1RH6 MT DTT DMT1RH6 MA Antagonist DMT1RH6 RN The pipeline and future of drug development in schizophrenia. Mol Psychiatry. 2007 Oct;12(10):904-22. DMT1RH6 RU https://pubmed.ncbi.nlm.nih.gov/17667958 DMHXRN8 DI DMHXRN8 DMHXRN8 DN GNI-104 DMHXRN8 MI TTXAKVF DMHXRN8 MN Hepatitis C virus Envelope glycoprotein (HCV Env) DMHXRN8 MT DTT DMHXRN8 RN WO patent application no. 2009,1433,45, Nucleic acid silencing agent-protein conjugates and use thereof for treating hcv-related disorders. DMHXRN8 RU http://worldwide.espacenet.com/publicationDetails/biblio?DB=worldwide.espacenet.com&II=0&ND=3&adjacent=true&locale=en_EP&FT=D&date=20091126&CC=WO&NR=2009143345A2&KC=A2 DMPODL9 DI DMPODL9 DMPODL9 DN GP-683 DMPODL9 MI TTL732K DMPODL9 MN Adenosine kinase (ADK) DMPODL9 MT DTT DMPODL9 MA Inhibitor DMPODL9 RN The effect of GP683, an adenosine kinase inhibitor, on the desflurane anesthetic requirement in dogs. Anesth Analg. 1997 Sep;85(3):675-80. DMPODL9 RU https://pubmed.ncbi.nlm.nih.gov/9296430 DMD5WK4 DI DMD5WK4 DMD5WK4 DN Gpi-1046 DMD5WK4 MI TTMW94E DMD5WK4 MN FK506-binding protein 1A (FKBP1A) DMD5WK4 MT DTT DMD5WK4 MA Inhibitor DMD5WK4 RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DMD5WK4 RU https://pubmed.ncbi.nlm.nih.gov/10592235 DMBMAPH DI DMBMAPH DMBMAPH DN GPI-3000 DMBMAPH MI TT9IK2Z DMBMAPH MN N-methyl-D-aspartate receptor (NMDAR) DMBMAPH MT DTT DMBMAPH MA Modulator DMBMAPH RN Treatment with the competitive NMDA antagonist GPI 3000 does not improve outcome after cardiac arrest in dogs. Stroke. 1998 Apr;29(4):824-9. DMBMAPH RU https://pubmed.ncbi.nlm.nih.gov/9550518 DM01HLX DI DM01HLX DM01HLX DN GR-127935 DM01HLX MI TTK8CXU DM01HLX MN 5-HT 1B receptor (HTR1B) DM01HLX MT DTT DM01HLX MA Modulator DM01HLX RN GR127935: a potent and selective 5-HT1D receptor antagonist.Behav Brain Res.1996;73(1-2):157-61. DM01HLX RU https://www.ncbi.nlm.nih.gov/pubmed/8788495 DM01HLX DI DM01HLX DM01HLX DN GR-127935 DM01HLX MI TT6MSOK DM01HLX MN 5-HT 1D receptor (HTR1D) DM01HLX MT DTT DM01HLX MA Modulator DM01HLX RN GR127935: a potent and selective 5-HT1D receptor antagonist.Behav Brain Res.1996;73(1-2):157-61. DM01HLX RU https://www.ncbi.nlm.nih.gov/pubmed/8788495 DMKAGLV DI DMKAGLV DMKAGLV DN GR-131663 DMKAGLV MI TT0WAIE DMKAGLV MN Melatonin receptor type 1A (MTNR1A) DMKAGLV MT DTT DMKAGLV MA Modulator DMKAGLV RN Novel non-indolic melatonin receptor agonists differentially entrain endogenous melatonin rhythm and increase its amplitude. Eur J Pharmacol. 1999 Oct 15;382(3):157-66. DMKAGLV RU https://pubmed.ncbi.nlm.nih.gov/10556666 DMNRJA0 DI DMNRJA0 DMNRJA0 DN GR-133347 DMNRJA0 MI TT0WAIE DMNRJA0 MN Melatonin receptor type 1A (MTNR1A) DMNRJA0 MT DTT DMNRJA0 MA Modulator DMNRJA0 RN US patent application no. 5,151,446, Substituted 2-amidotetralins as melatonin agonists and antagonists. DMNRJA0 RU http://www.google.com/patents/US5151446 DMN8TH1 DI DMN8TH1 DMN8TH1 DN GR-144053 DMN8TH1 MI TT38RM1 DMN8TH1 MN Glycoprotein IIb/IIIa receptor (GPIIb/IIIa) DMN8TH1 MT DTT DMN8TH1 MA Modulator DMN8TH1 RN GR144053, a fibrinogen receptor antagonist, enhances the suppression of neointima formation by losartan, an angiotensin II receptor antagonist, in ... Br J Pharmacol. 1997 Nov;122(6):1099-104. DMN8TH1 RU https://www.ncbi.nlm.nih.gov/pubmed/9480031 DMLQ71Y DI DMLQ71Y DMLQ71Y DN GR-159897 DMLQ71Y MI TTYO0A3 DMLQ71Y MN Substance-K receptor (TACR2) DMLQ71Y MT DTT DMLQ71Y MA Modulator DMLQ71Y RN GR159897, a potent non-peptide antagonist at tachykinin NK2 receptors. Eur J Pharmacol. 1995 Jan 16;272(2-3):241-8. DMLQ71Y RU https://pubmed.ncbi.nlm.nih.gov/7713168 DMOY8UA DI DMOY8UA DMOY8UA DN GR-175737 DMOY8UA MI TT9JNIC DMOY8UA MN Histamine H3 receptor (H3R) DMOY8UA MT DTT DMOY8UA MA Inhibitor DMOY8UA RN New acetylene based histamine H3 receptor antagonists derived from the marine natural product verongamine. Bioorg Med Chem Lett. 1998 May 19;8(10):1133-8. DMOY8UA RU https://pubmed.ncbi.nlm.nih.gov/9871722 DMA7FX1 DI DMA7FX1 DMA7FX1 DN GR-199114X DMA7FX1 MI TTVFO0U DMA7FX1 MN Gastrin/cholecystokinin type B receptor (CCKBR) DMA7FX1 MT DTT DMA7FX1 MA Modulator DMA7FX1 RN Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800009210) DMA7FX1 RU http://adisinsight.springer.com/drugs/800009210 DMIJCH1 DI DMIJCH1 DMIJCH1 DN GR-218231 DMIJCH1 MI TT4C8EA DMIJCH1 MN Dopamine D3 receptor (D3R) DMIJCH1 MT DTT DMIJCH1 MA Inhibitor DMIJCH1 RN Design, synthesis, and binding affinities of potential positron emission tomography (PET) ligands with optimal lipophilicity for brain imaging of t... Bioorg Med Chem. 2009 Jan 15;17(2):758-66. DMIJCH1 RU https://pubmed.ncbi.nlm.nih.gov/19081257 DMHM0EU DI DMHM0EU DMHM0EU DN GR-233548 DMHM0EU MI TT38RM1 DMHM0EU MN Glycoprotein IIb/IIIa receptor (GPIIb/IIIa) DMHM0EU MT DTT DMHM0EU MA Modulator DMHM0EU RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. DMHM0EU RU https://www.fda.gov/ DMRPE3D DI DMRPE3D DMRPE3D DN GR-65630 DMRPE3D MI TTNXLKE DMRPE3D MN 5-HT 3 receptor (5HT3R) DMRPE3D MT DTT DMRPE3D MA Modulator DMRPE3D RN Binding of the 5-HT3 ligand, [3H]GR65630, to rat area postrema, vagus nerve and the brains of several species. Eur J Pharmacol. 1989 Jan 10;159(2):157-64. DMRPE3D RU https://pubmed.ncbi.nlm.nih.gov/2707305 DMR2TZK DI DMR2TZK DMR2TZK DN GR-82334 DMR2TZK MI TTZPO1L DMR2TZK MN Substance-P receptor (TACR1) DMR2TZK MT DTT DMR2TZK MA Antagonist DMR2TZK RN Effect of the NK-1 receptor antagonist GR 82,334 on reflexly-induced bladder contractions. Life Sci. 1992;51(26):PL277-80. DMR2TZK RU https://pubmed.ncbi.nlm.nih.gov/1335533 DMTGH8N DI DMTGH8N DMTGH8N DN GR-89696 DMTGH8N MI TTQW87Y DMTGH8N MN Opioid receptor kappa (OPRK1) DMTGH8N MT DTT DMTGH8N MA Modulator DMTGH8N RN [(11)C]-GR89696, a potent kappa opiate receptor radioligand; in vivo binding of the R and S enantiomers. Nucl Med Biol. 2002 Jan;29(1):47-53. DMTGH8N RU https://pubmed.ncbi.nlm.nih.gov/11786275 DM96KF7 DI DM96KF7 DM96KF7 DN GR-94839 DM96KF7 MI TTQW87Y DM96KF7 MN Opioid receptor kappa (OPRK1) DM96KF7 MT DTT DM96KF7 MA Modulator DM96KF7 RN GR94839, a kappa-opioid agonist with limited access to the central nervous system, has antinociceptive activity. Br J Pharmacol. 1992 Aug;106(4):783-9. DM96KF7 RU https://pubmed.ncbi.nlm.nih.gov/1327387 DMAHNF6 DI DMAHNF6 DMAHNF6 DN GR-95168 DMAHNF6 MI TTIU7X1 DMAHNF6 MN Herpes simplex virus DNA polymerase UL30 (HSV UL30) DMAHNF6 MT DTT DMAHNF6 MA Modulator DMAHNF6 RN US patent application no. 2004,0023,290, Novel therapeutic agents that modulate enzymatic processes. DMAHNF6 RU http://www.google.com/patents/US20040023290 DMPSZR0 DI DMPSZR0 DMPSZR0 DN GS-2992 DMPSZR0 MI TT5FNQT DMPSZR0 MN Human immunodeficiency virus Protease (HIV PR) DMPSZR0 MT DTT DMPSZR0 MA Modulator DMPSZR0 RN US patent application no. 2008,0161,324, Compositions and methods for treatment of viral diseases. DMPSZR0 RU http://www.google.com/patents/US20080161324 DMV7JC6 DI DMV7JC6 DMV7JC6 DN GS-3435 DMV7JC6 MI TT50QJ3 DMV7JC6 MN Influenza Neuraminidase (Influ NA) DMV7JC6 MT DTT DMV7JC6 MA Modulator DMV7JC6 RN US patent application no. 2010,0081,713, Compositions and methods for treating viral infections. DMV7JC6 RU http://www.google.com/patents/US20100081713 DMT6S9B DI DMT6S9B DMT6S9B DN GS-522 DMT6S9B MI TT6L509 DMT6S9B MN Coagulation factor IIa (F2) DMT6S9B MT DTT DMT6S9B MA Inhibitor DMT6S9B RN A novel oligodeoxynucleotide inhibitor of thrombin. I. In vitro metabolic stability in plasma and serum. Pharm Res. 1995 Dec;12(12):1937-42. DMT6S9B RU https://pubmed.ncbi.nlm.nih.gov/8786969 DMCYZL3 DI DMCYZL3 DMCYZL3 DN GS-9148 DMCYZL3 MI TT84ETX DMCYZL3 MN Human immunodeficiency virus Reverse transcriptase (HIV RT) DMCYZL3 MT DTT DMCYZL3 MA Inhibitor DMCYZL3 RN Novel nucleotide human immunodeficiency virus reverse transcriptase inhibitor GS-9148 with a low nephrotoxic potential: characterization of renal transport and accumulation. Antimicrob Agents Chemother. 2009 Jan;53(1):150-6. DMCYZL3 RU https://pubmed.ncbi.nlm.nih.gov/19001108 DMQSMB1 DI DMQSMB1 DMQSMB1 DN GS-9160 DMQSMB1 MI TT5FH9Y DMQSMB1 MN Human immunodeficiency virus Integrase (HIV IN) DMQSMB1 MT DTT DMQSMB1 MA Inhibitor DMQSMB1 RN Preclinical evaluation of GS-9160, a novel inhibitor of human immunodeficiency virus type 1 integrase. Antimicrob Agents Chemother. 2009 Mar;53(3):1194-203. DMQSMB1 RU https://pubmed.ncbi.nlm.nih.gov/19104010 DMOALVR DI DMOALVR DMOALVR DN GSK-2485852 DMOALVR MI TTMVBWH DMOALVR MN Hepatitis C virus RNA-directed RNA polymerase (HCV NS5B) DMOALVR MT DTT DMOALVR MA Inhibitor DMOALVR RN In vitro characterization of GSK2485852, a novel hepatitis C virus polymerase inhibitor. Antimicrob Agents Chemother. 2013 Nov;57(11):5216-24. DMOALVR RU https://pubmed.ncbi.nlm.nih.gov/23939896 DMMYUWT DI DMMYUWT DMMYUWT DN GSK-923295 DMMYUWT MI TTZD5QR DMMYUWT MN Centromeric protein E (CENPE) DMMYUWT MT DTT DMMYUWT MA Inhibitor DMMYUWT RN Cytokinetics Announces Non-Clinical Trial Data Presented at 2007 AACR Annual Meeting. Cytokinetics, Incorporated. 2007. DMMYUWT RU http://www.newsrx.com/newsletters/Blood-Weekly/2007-05-10/80510200710BW.html DMA6RL2 DI DMA6RL2 DMA6RL2 DN GT-16-239 DMA6RL2 MI TTPADOQ DMA6RL2 MN HMG-CoA reductase (HMGCR) DMA6RL2 MT DTT DMA6RL2 MA Modulator DMA6RL2 RN Studies of cholesterol and bile acid metabolism, and early atherogenesis in hamsters fed GT16-239, a novel bile acid sequestrant (BAS). Atherosclerosis. 1998 Oct;140(2):315-24. DMA6RL2 RU https://pubmed.ncbi.nlm.nih.gov/9862274 DM42XHS DI DM42XHS DM42XHS DN GT-2016 DM42XHS MI TT9JNIC DM42XHS MN Histamine H3 receptor (H3R) DM42XHS MT DTT DM42XHS MA Inhibitor DM42XHS RN New acetylene based histamine H3 receptor antagonists derived from the marine natural product verongamine. Bioorg Med Chem Lett. 1998 May 19;8(10):1133-8. DM42XHS RU https://pubmed.ncbi.nlm.nih.gov/9871722 DMJ4PNR DI DMJ4PNR DMJ4PNR DN GT-2203 DMJ4PNR MI TT9JNIC DMJ4PNR MN Histamine H3 receptor (H3R) DMJ4PNR MT DTT DMJ4PNR MA Agonist DMJ4PNR RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 264). DMJ4PNR RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=264 DMGSN1V DI DMGSN1V DMGSN1V DN GW-275175 DMGSN1V MI TTZHSBO DMGSN1V MN Cytomegalovirus Terminase (CMV TRM) DMGSN1V MT DTT DMGSN1V MA Inhibitor DMGSN1V RN Progress in Drug Research, 2012. Page(106). DMGSN1V RU https://books.google.com.hk/books?id=MoEECAAAQBAJ&pg=PA106&lpg=PA106&dq=%22GW-275175%22++terminase&source=bl&ots=f4vjuv3udg&sig=PDAZfA0gFYZn-7A4DEHDiG2ffEY&hl=zh-CN&sa=X&ved=0CBwQ6AEwAGoVChMIg9Tgov_AyAIVFAmOCh1lPgeT#v=onepage&q=%22GW-275175%22%20%20terminase&f=false DMUG82P DI DMUG82P DMUG82P DN GW-278884 DMUG82P MI TT3C1VN DMUG82P MN Enzyme unspecific (Enz) DMUG82P MT DTT DMUG82P MA Modulator DMUG82P RN WO patent application no. 2010,1112,71, Orally bioavailable lipid-based constructs. DMUG82P RU http://worldwide.espacenet.com/publicationDetails/biblio?DB=worldwide.espacenet.com&II=0&ND=3&adjacent=true&locale=en_EP&FT=D&date=20100930&CC=WO&NR=2010111271A1&KC=A1 DMSZH0I DI DMSZH0I DMSZH0I DN GW-3600 DMSZH0I MI TTZ97H5 DMSZH0I MN Phosphodiesterase 4A (PDE4A) DMSZH0I MT DTT DMSZH0I MA Inhibitor DMSZH0I RN Dual inhibition of human type 4 phosphodiesterase isostates by (R, R)-(+/-)-methyl 3-acetyl-4-[3-(cyclopentyloxy)-4-methoxyphenyl]-3- methyl-1-pyrrolidinecarboxylate. Biochemistry. 1998 May 12;37(19):6894-904. DMSZH0I RU https://pubmed.ncbi.nlm.nih.gov/9578576 DMSZH0I DI DMSZH0I DMSZH0I DN GW-3600 DMSZH0I MI TTVIAT9 DMSZH0I MN Phosphodiesterase 4B (PDE4B) DMSZH0I MT DTT DMSZH0I MA Inhibitor DMSZH0I RN Dual inhibition of human type 4 phosphodiesterase isostates by (R, R)-(+/-)-methyl 3-acetyl-4-[3-(cyclopentyloxy)-4-methoxyphenyl]-3- methyl-1-pyrrolidinecarboxylate. Biochemistry. 1998 May 12;37(19):6894-904. DMSZH0I RU https://pubmed.ncbi.nlm.nih.gov/9578576 DMSZH0I DI DMSZH0I DMSZH0I DN GW-3600 DMSZH0I MI TTSKMI8 DMSZH0I MN Phosphodiesterase 4D (PDE4D) DMSZH0I MT DTT DMSZH0I MA Inhibitor DMSZH0I RN Dual inhibition of human type 4 phosphodiesterase isostates by (R, R)-(+/-)-methyl 3-acetyl-4-[3-(cyclopentyloxy)-4-methoxyphenyl]-3- methyl-1-pyrrolidinecarboxylate. Biochemistry. 1998 May 12;37(19):6894-904. DMSZH0I RU https://pubmed.ncbi.nlm.nih.gov/9578576 DMG5A1Z DI DMG5A1Z DMG5A1Z DN GW-660511 DMG5A1Z MI TTL69WB DMG5A1Z MN Angiotensin-converting enzyme (ACE) DMG5A1Z MT DTT DMG5A1Z MA Modulator DMG5A1Z RN The effects of Z13752A, a combined ACE/NEP inhibitor, on responses to coronary artery occlusion; a primary protective role for bradykinin. Br J Pharmacol. 2000 Feb;129(4):671-80. DMG5A1Z RU https://pubmed.ncbi.nlm.nih.gov/10683191 DMG5A1Z DI DMG5A1Z DMG5A1Z DN GW-660511 DMG5A1Z MI TT5TKPM DMG5A1Z MN Neutral endopeptidase (MME) DMG5A1Z MT DTT DMG5A1Z MA Modulator DMG5A1Z RN The effects of Z13752A, a combined ACE/NEP inhibitor, on responses to coronary artery occlusion; a primary protective role for bradykinin. Br J Pharmacol. 2000 Feb;129(4):671-80. DMG5A1Z RU https://pubmed.ncbi.nlm.nih.gov/10683191 DMPLYHU DI DMPLYHU DMPLYHU DN GW-974 DMPLYHU MI TT6EO5L DMPLYHU MN Erbb2 tyrosine kinase receptor (HER2) DMPLYHU MT DTT DMPLYHU MA Inhibitor DMPLYHU RN WO patent application no. 2005,0443,02, Selective erbb2 inhibitor/anti-erbb antibody combinations in the treatment of cancer. DMPLYHU RU http://worldwide.espacenet.com/publicationDetails/biblio?DB=worldwide.espacenet.com&II=0&ND=3&adjacent=true&locale=en_EP&FT=D&date=20050519&CC=WO&NR=2005044302A1&KC=A1 DM3YG5P DI DM3YG5P DM3YG5P DN GYKI-52466 DM3YG5P MI TTAN6JD DM3YG5P MN Glutamate receptor AMPA (GRIA) DM3YG5P MT DTT DM3YG5P MA Inhibitor DM3YG5P RN New 7,8-ethylenedioxy-2,3-benzodiazepines as noncompetitive AMPA receptor antagonists. Bioorg Med Chem Lett. 2006 Jan 1;16(1):167-70. DM3YG5P RU https://pubmed.ncbi.nlm.nih.gov/16216501 DM3YG5P DI DM3YG5P DM3YG5P DN GYKI-52466 DM3YG5P MI TTVPQTF DM3YG5P MN Glutamate receptor AMPA 1 (GRIA1) DM3YG5P MT DTT DM3YG5P MA Inhibitor DM3YG5P RN New 7,8-ethylenedioxy-2,3-benzodiazepines as noncompetitive AMPA receptor antagonists. Bioorg Med Chem Lett. 2006 Jan 1;16(1):167-70. DM3YG5P RU https://pubmed.ncbi.nlm.nih.gov/16216501 DMC0JN8 DI DMC0JN8 DMC0JN8 DN GYKI-53655 DMC0JN8 MI TTAN6JD DMC0JN8 MN Glutamate receptor AMPA (GRIA) DMC0JN8 MT DTT DMC0JN8 MA Inhibitor DMC0JN8 RN Substituted 1,2-dihydrophthalazines: potent, selective, and noncompetitive inhibitors of the AMPA receptor. J Med Chem. 1996 Jan 19;39(2):343-6. DMC0JN8 RU https://pubmed.ncbi.nlm.nih.gov/8558499 DMC0JN8 DI DMC0JN8 DMC0JN8 DN GYKI-53655 DMC0JN8 MI TTVPQTF DMC0JN8 MN Glutamate receptor AMPA 1 (GRIA1) DMC0JN8 MT DTT DMC0JN8 MA Inhibitor DMC0JN8 RN Substituted 1,2-dihydrophthalazines: potent, selective, and noncompetitive inhibitors of the AMPA receptor. J Med Chem. 1996 Jan 19;39(2):343-6. DMC0JN8 RU https://pubmed.ncbi.nlm.nih.gov/8558499 DM904UQ DI DM904UQ DM904UQ DN H-216/44 DM904UQ MI TTMXGCW DM904UQ MN Adrenergic receptor beta-3 (ADRB3) DM904UQ MT DTT DM904UQ MA Modulator DM904UQ RN Binding of the beta-blockers timolol and H 216/44 to ocular melanin. Exp Eye Res. 1988 Oct;47(4):565-77. DM904UQ RU https://pubmed.ncbi.nlm.nih.gov/2903066 DMMCI4H DI DMMCI4H DMMCI4H DN HELENALIN DMMCI4H MI TT8DBY3 DMMCI4H MN Angiotensin II receptor type-1 (AGTR1) DMMCI4H MT DTT DMMCI4H MA Inhibitor DMMCI4H RN In silico identification and biochemical evaluation of novel inhibitors of NRH:quinone oxidoreductase 2 (NQO2). Bioorg Med Chem Lett. 2010 Dec 15;20(24):7331-6. DMMCI4H RU https://pubmed.ncbi.nlm.nih.gov/21074425 DMMCI4H DI DMMCI4H DMMCI4H DN HELENALIN DMMCI4H MI TTSXVID DMMCI4H MN Nuclear factor NF-kappa-B (NFKB) DMMCI4H MT DTT DMMCI4H MA Inhibitor DMMCI4H RN Quantitative structure-activity relationship of sesquiterpene lactones as inhibitors of the transcription factor NF-kappaB. J Med Chem. 2004 Nov 18;47(24):6042-54. DMMCI4H RU https://pubmed.ncbi.nlm.nih.gov/15537359 DM5HMZW DI DM5HMZW DM5HMZW DN Hementin DM5HMZW MI TT6L509 DM5HMZW MN Coagulation factor IIa (F2) DM5HMZW MT DTT DM5HMZW MA Inhibitor DM5HMZW RN Hementin: anticoagulant protease from the salivary gland of the leech Haementeria ghilianii. J Lab Clin Med. 1984 Jan;103(1):44-58. DM5HMZW RU https://pubmed.ncbi.nlm.nih.gov/6361187 DMMXG2I DI DMMXG2I DMMXG2I DN Heparin-EGF-like factor DMMXG2I MI TTGKNB4 DMMXG2I MN Epidermal growth factor receptor (EGFR) DMMXG2I MT DTT DMMXG2I MA Modulator DMMXG2I RN The heparin-binding domain of heparin-binding EGF-like growth factor can target Pseudomonas exotoxin to kill cells exclusively through heparan sulfate proteoglycans. J Cell Sci. 1994 Sep;107 ( Pt 9):2599-608. DMMXG2I RU https://pubmed.ncbi.nlm.nih.gov/7844173 DMGAKD8 DI DMGAKD8 DMGAKD8 DN HIMBACINE DMGAKD8 MI TTZ9SOR DMGAKD8 MN Muscarinic acetylcholine receptor M1 (CHRM1) DMGAKD8 MT DTT DMGAKD8 MA Inhibitor DMGAKD8 RN Himbacine analogs as muscarinic receptor antagonists--effects of tether and heterocyclic variations. Bioorg Med Chem Lett. 2004 Aug 2;14(15):3967-70. DMGAKD8 RU https://pubmed.ncbi.nlm.nih.gov/15225708 DMGAKD8 DI DMGAKD8 DMGAKD8 DN HIMBACINE DMGAKD8 MI TTYEG6Q DMGAKD8 MN Muscarinic acetylcholine receptor M2 (CHRM2) DMGAKD8 MT DTT DMGAKD8 MA Inhibitor DMGAKD8 RN Himbacine analogs as muscarinic receptor antagonists--effects of tether and heterocyclic variations. Bioorg Med Chem Lett. 2004 Aug 2;14(15):3967-70. DMGAKD8 RU https://pubmed.ncbi.nlm.nih.gov/15225708 DM784QJ DI DM784QJ DM784QJ DN Hirufaxin DM784QJ MI TTCIHJA DM784QJ MN Coagulation factor Xa (F10) DM784QJ MT DTT DM784QJ MA Inhibitor DM784QJ RN Semuloparin for the prevention of venous thromboembolic events in cancer patients. Drugs Today (Barc). 2012 Jul;48(7):451-7. DM784QJ RU https://pubmed.ncbi.nlm.nih.gov/22844656 DMCHFIT DI DMCHFIT DMCHFIT DN HMR-3787 DMCHFIT MI TTUWYEA DMCHFIT MN Bacterial 50S ribosomal RNA (Bact 50S rRNA) DMCHFIT MT DTT DMCHFIT MA Modulator DMCHFIT RN Structure-activity relationships for six ketolide antibiotics. Curr Microbiol. 2001 Mar;42(3):203-10. DMCHFIT RU https://pubmed.ncbi.nlm.nih.gov/11270656 DML0B97 DI DML0B97 DML0B97 DN HOE-694 DML0B97 MI TTGSEFH DML0B97 MN Sodium/hydrogen exchanger 1 (SLC9A1) DML0B97 MT DTT DML0B97 MA Inhibitor DML0B97 RN (2-Methyl-5-(methylsulfonyl)benzoyl)guanidine Na+/H+ antiporter inhibitors. J Med Chem. 1997 Jun 20;40(13):2017-34. DML0B97 RU https://pubmed.ncbi.nlm.nih.gov/9207943 DML0B97 DI DML0B97 DML0B97 DN HOE-694 DML0B97 MI TTFZVPO DML0B97 MN Sodium/hydrogen exchanger 3 (SLC9A3) DML0B97 MT DTT DML0B97 MA Inhibitor DML0B97 RN (2-Methyl-5-(methylsulfonyl)benzoyl)guanidine Na+/H+ antiporter inhibitors. J Med Chem. 1997 Jun 20;40(13):2017-34. DML0B97 RU https://pubmed.ncbi.nlm.nih.gov/9207943 DMHP9WV DI DMHP9WV DMHP9WV DN HOMOEPIBATIDINE DMHP9WV MI TT4H1MQ DMHP9WV MN Neuronal acetylcholine receptor alpha-4 (CHRNA4) DMHP9WV MT DTT DMHP9WV MA Inhibitor DMHP9WV RN Epibatidine isomers and analogues: structure-activity relationships. Bioorg Med Chem Lett. 2006 Nov 1;16(21):5493-7. DMHP9WV RU https://pubmed.ncbi.nlm.nih.gov/16934977 DMHP9WV DI DMHP9WV DMHP9WV DN HOMOEPIBATIDINE DMHP9WV MI TT5KPZR DMHP9WV MN Neuronal acetylcholine receptor beta-2 (CHRNB2) DMHP9WV MT DTT DMHP9WV MA Inhibitor DMHP9WV RN Epibatidine isomers and analogues: structure-activity relationships. Bioorg Med Chem Lett. 2006 Nov 1;16(21):5493-7. DMHP9WV RU https://pubmed.ncbi.nlm.nih.gov/16934977 DMHP9WV DI DMHP9WV DMHP9WV DN HOMOEPIBATIDINE DMHP9WV MI TTTVAFQ DMHP9WV MN Neuronal acetylcholine receptor beta-4 (CHRNB4) DMHP9WV MT DTT DMHP9WV MA Inhibitor DMHP9WV RN Epibatidine isomers and analogues: structure-activity relationships. Bioorg Med Chem Lett. 2006 Nov 1;16(21):5493-7. DMHP9WV RU https://pubmed.ncbi.nlm.nih.gov/16934977 DMEZ5P2 DI DMEZ5P2 DMEZ5P2 DN HRC-101 DMEZ5P2 MI TTQO71U DMEZ5P2 MN Hemoglobin (HB) DMEZ5P2 MT DTT DMEZ5P2 MA Modulator DMEZ5P2 RN The novel hemoglobin-based oxygen carrier HRC 101 improves survival in murine sickle cell disease. Anesthesiology. 2007 Aug;107(2):281-7. DMEZ5P2 RU https://pubmed.ncbi.nlm.nih.gov/17667573 DMJACXN DI DMJACXN DMJACXN DN HRC-102 DMJACXN MI TTQO71U DMJACXN MN Hemoglobin (HB) DMJACXN MT DTT DMJACXN MA Modulator DMJACXN RN WO patent application no. 2013,1850,32, Nanotherapeutics for drug targeting. DMJACXN RU http://worldwide.espacenet.com/publicationDetails/biblio?DB=worldwide.espacenet.com&II=0&ND=3&adjacent=true&locale=en_EP&FT=D&date=20131212&CC=WO&NR=2013185032A1&KC=A1 DM5A3GX DI DM5A3GX DM5A3GX DN HRC-201 DM5A3GX MI TTQO71U DM5A3GX MN Hemoglobin (HB) DM5A3GX MT DTT DM5A3GX MA Enhancer DM5A3GX RN WO patent application no. 2013,1850,32, Nanotherapeutics for drug targeting. DM5A3GX RU http://worldwide.espacenet.com/publicationDetails/biblio?DB=worldwide.espacenet.com&II=0&ND=3&adjacent=true&locale=en_EP&FT=D&date=20131212&CC=WO&NR=2013185032A1&KC=A1 DMQINWF DI DMQINWF DMQINWF DN HT-90B DMQINWF MI TTSQIFT DMQINWF MN 5-HT 1A receptor (HTR1A) DMQINWF MT DTT DMQINWF MA Modulator DMQINWF RN Pharmacological profile of (-)HT-90B, a novel 5-HT1A receptor agonist/5-HT2 receptor antagonist. Prog Neuropsychopharmacol Biol Psychiatry. 1995 Nov;19(7):1201-16. DMQINWF RU https://pubmed.ncbi.nlm.nih.gov/8787043 DMK1VHF DI DMK1VHF DMK1VHF DN Hu Dreg 55 DMK1VHF MI TT2IYXF DMK1VHF MN L-selectin (SELL) DMK1VHF MT DTT DMK1VHF RN Clinical pipeline report, company report or official report of glycomimetics. DMK1VHF RU http://www.glycomimetics.com/programs-pipeline/gmi-1271/ DMTGCA6 DI DMTGCA6 DMTGCA6 DN HuCD40L DMTGCA6 MI TTN6Y9A DMTGCA6 MN CD40L receptor (CD40) DMTGCA6 MT DTT DMTGCA6 MA Binder DMTGCA6 RN Recombinant human CD40 ligand inhibits simian immunodeficiency virus replication: a role for interleukin- 16. J Med Primatol. 1999 Aug-Oct;28(4-5):190-4. DMTGCA6 RU https://pubmed.ncbi.nlm.nih.gov/10593485 DMA7EFM DI DMA7EFM DMA7EFM DN Human chorionic gonadotropin DMA7EFM MI TT2O4W9 DMA7EFM MN Luteinizing hormone receptor (LHCGR) DMA7EFM MT DTT DMA7EFM MA Inhibitor DMA7EFM RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 254). DMA7EFM RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=254 DMFVB7Z DI DMFVB7Z DMFVB7Z DN HuMax-HepC DMFVB7Z MI TTDBG95 DMFVB7Z MN Hepatitis C virus Envelope glycoprotein E2 (HCV NS1) DMFVB7Z MT DTT DMFVB7Z RN Clinical pipeline report, company report or official report of Genmab. DMFVB7Z RU http://www.genmab.com/docs/products/humax-hepc-fact-sheet.pdf DM8BSF3 DI DM8BSF3 DM8BSF3 DN HuMax-TAC DM8BSF3 MI TT10Y9E DM8BSF3 MN Interleukin 2 receptor alpha (IL2RA) DM8BSF3 MT DTT DM8BSF3 RN Biosynthesis, synthesis, and biological activities of pyrrolobenzodiazepines. Med Res Rev. 2012 Mar;32(2):254-93. DM8BSF3 RU https://pubmed.ncbi.nlm.nih.gov/20544978 DM37KVY DI DM37KVY DM37KVY DN HY-12638 DM37KVY MI DEMQRS9 DM37KVY MN Cytochrome P450 BM3 (cypBM3) DM37KVY MT DME DM37KVY MA Metabolism DM37KVY RN PEGylation of cytochrome P450 enhances its biocatalytic performance for pesticide transformation. Int J Biol Macromol. 2017 Dec;105(Pt 1):163-170. DM37KVY RU https://pubmed.ncbi.nlm.nih.gov/28690168 DM4HA9C DI DM4HA9C DM4HA9C DN HydrocoDex DM4HA9C MI TT5TPI6 DM4HA9C MN Opioid receptor sigma 1 (OPRS1) DM4HA9C MT DTT DM4HA9C MA Modulator DM4HA9C RN Antitussives and substance abuse. Subst Abuse Rehabil. 2013 Nov 6;4:75-82. DM4HA9C RU https://pubmed.ncbi.nlm.nih.gov/24648790 DM4HA9C DI DM4HA9C DM4HA9C DN HydrocoDex DM4HA9C MI TT3ROYC DM4HA9C MN Serotonin transporter (SERT) DM4HA9C MT DTT DM4HA9C MA Modulator DM4HA9C RN Antitussives and substance abuse. Subst Abuse Rehabil. 2013 Nov 6;4:75-82. DM4HA9C RU https://pubmed.ncbi.nlm.nih.gov/24648790 DM1C4IG DI DM1C4IG DM1C4IG DN ICA-1 DM1C4IG MI TTWJTHX DM1C4IG MN Protein kinase C iota (PRKCI) DM1C4IG MT DTT DM1C4IG MA Inhibitor DM1C4IG RN A novel PKC- inhibitor abrogates cell proliferation and induces apoptosis in neuroblastoma. Int J Biochem Cell Biol. 2011 May;43(5):784-94. DM1C4IG RU https://pubmed.ncbi.nlm.nih.gov/21315177 DMYN3WG DI DMYN3WG DMYN3WG DN ICI-164384 DMYN3WG MI TTZAYWL DMYN3WG MN Estrogen receptor (ESR) DMYN3WG MT DTT DMYN3WG MA Inhibitor DMYN3WG RN Synthesis and biological activity of new halo-steroidal antiestrogens. J Med Chem. 1991 May;34(5):1624-30. DMYN3WG RU https://pubmed.ncbi.nlm.nih.gov/2033587 DMYN3WG DI DMYN3WG DMYN3WG DN ICI-164384 DMYN3WG MI TTOM3J0 DMYN3WG MN Estrogen receptor beta (ESR2) DMYN3WG MT DTT DMYN3WG MA Inhibitor DMYN3WG RN Synthesis and biological activity of new halo-steroidal antiestrogens. J Med Chem. 1991 May;34(5):1624-30. DMYN3WG RU https://pubmed.ncbi.nlm.nih.gov/2033587 DMQ0IOF DI DMQ0IOF DMQ0IOF DN ICI-169369 DMQ0IOF MI TTJQOD7 DMQ0IOF MN 5-HT 2A receptor (HTR2A) DMQ0IOF MT DTT DMQ0IOF MA Modulator DMQ0IOF RN Serotonin 5-HT(2A) receptor antagonists in the treatment of insomnia: present status and future prospects.Drugs Today (Barc).2010 Mar;46(3):183-93. DMQ0IOF RU https://www.ncbi.nlm.nih.gov/pubmed/20467592 DMQ0IOF DI DMQ0IOF DMQ0IOF DN ICI-169369 DMQ0IOF MI TTWJBZ5 DMQ0IOF MN 5-HT 2C receptor (HTR2C) DMQ0IOF MT DTT DMQ0IOF MA Modulator DMQ0IOF RN Serotonin 5-HT(2A) receptor antagonists in the treatment of insomnia: present status and future prospects.Drugs Today (Barc).2010 Mar;46(3):183-93. DMQ0IOF RU https://www.ncbi.nlm.nih.gov/pubmed/20467592 DM0XU4P DI DM0XU4P DM0XU4P DN ICI-181037 DM0XU4P MI TT1VOHK DM0XU4P MN Potassium channel unspecific (KC) DM0XU4P MT DTT DM0XU4P MA Opener DM0XU4P RN ICI 181,037: a novel eukalemic diuretic with antiarrhythmic activity. Jpn J Pharmacol. 1991 Nov;57(3):263-77. DM0XU4P RU https://pubmed.ncbi.nlm.nih.gov/1813657 DM0195G DI DM0195G DM0195G DN ICI-198615 DM0195G MI TTGKOY9 DM0195G MN Leukotriene CysLT1 receptor (CYSLTR1) DM0195G MT DTT DM0195G MA Antagonist DM0195G RN Heterogeneity of binding sites for ICI 198,615 in human lung parenchyma. Biochem Pharmacol. 1992 Oct 6;44(7):1411-5. DM0195G RU https://pubmed.ncbi.nlm.nih.gov/1329767 DM0195G DI DM0195G DM0195G DN ICI-198615 DM0195G MI TT0PZR5 DM0195G MN Leukotriene CysLT2 receptor (CYSLTR2) DM0195G MT DTT DM0195G MA Antagonist DM0195G RN Heterogeneity of binding sites for ICI 198,615 in human lung parenchyma. Biochem Pharmacol. 1992 Oct 6;44(7):1411-5. DM0195G RU https://pubmed.ncbi.nlm.nih.gov/1329767 DM0195G DI DM0195G DM0195G DN ICI-198615 DM0195G MI TTTWGIX DM0195G MN Leukotriene receptor (LTR) DM0195G MT DTT DM0195G MA Modulator DM0195G RN In vitro pharmacology of ICI 198,615: a novel, potent and selective peptide leukotriene antagonist. J Pharmacol Exp Ther. 1987 Nov;243(2):548-56. DM0195G RU https://pubmed.ncbi.nlm.nih.gov/2824751 DMDBICR DI DMDBICR DMDBICR DN ICM-3 DMDBICR MI TTD26RC DMDBICR MN Cell adhesion molecule (CADM) DMDBICR MT DTT DMDBICR RN Anti-tumor activity of an ICAM-3 antibody (ICM3) Against human leukemic xenograft tumors in nude mice. Volume 28, Issue 7, Supplement 1, 1 July 2000, Pages 59-60. DMDBICR RU http://www.sciencedirect.com/science/article/pii/S0301472X00002745 DMG1FQW DI DMG1FQW DMG1FQW DN IDRA-21 DMG1FQW MI TTAN6JD DMG1FQW MN Glutamate receptor AMPA (GRIA) DMG1FQW MT DTT DMG1FQW MA Modulator DMG1FQW RN IDRA-21, a positive AMPA receptor modulator, inhibits synaptic and extrasynaptic NMDA receptor mediated events in cultured cerebellar granule cells. Neuropharmacology. 2004 Jun;46(8):1105-13. DMG1FQW RU https://pubmed.ncbi.nlm.nih.gov/15111017 DMG1FQW DI DMG1FQW DMG1FQW DN IDRA-21 DMG1FQW MI TT9IK2Z DMG1FQW MN N-methyl-D-aspartate receptor (NMDAR) DMG1FQW MT DTT DMG1FQW MA Modulator DMG1FQW RN IDRA-21, a positive AMPA receptor modulator, inhibits synaptic and extrasynaptic NMDA receptor mediated events in cultured cerebellar granule cells. Neuropharmacology. 2004 Jun;46(8):1105-13. DMG1FQW RU https://pubmed.ncbi.nlm.nih.gov/15111017 DM16S98 DI DM16S98 DM16S98 DN IGE-026 DM16S98 MI TTYJQTF DM16S98 MN Immunoglobulin E (IgE) DM16S98 MT DTT DM16S98 MA Inhibitor DM16S98 RN IgE inhibition as a therapy for allergic disease. Int Arch Allergy Immunol. 1999 Feb-Apr;118(2-4):112-5. DM16S98 RU https://pubmed.ncbi.nlm.nih.gov/10224354 DMBKZ4R DI DMBKZ4R DMBKZ4R DN IGN-311 DMBKZ4R MI TTV75BJ DMBKZ4R MN Carbohydrate antigen Lewis-Y (Lewis-Y) DMBKZ4R MT DTT DMBKZ4R RN IGN-311. Igeneon. Curr Opin Investig Drugs. 2005 Dec;6(12):1272-9. DMBKZ4R RU https://pubmed.ncbi.nlm.nih.gov/16370394 DMKS4Z9 DI DMKS4Z9 DMKS4Z9 DN IL1aQb DMKS4Z9 MI TTPM6HI DMKS4Z9 MN Interleukin-1 alpha (IL1A) DMKS4Z9 MT DTT DMKS4Z9 RN Cytos Biotechnology AG - Product Pipeline Review - 2013. Global Markets Direct. Dec 2013. DMKS4Z9 RU http://www.researchmoz.us/cytos-biotechnology-ag-product-pipeline-review-2013-report.html DMWTFO3 DI DMWTFO3 DMWTFO3 DN IMAZODAN DMWTFO3 MI TTJGW1Z DMWTFO3 MN Phosphodiesterase 2A (PDE2A) DMWTFO3 MT DTT DMWTFO3 MA Inhibitor DMWTFO3 RN Cardiotonic agents. 1. 4,5-Dihydro-6-[4-(1H-imidazol-1-yl)phenyl]-3 (2H)-pyridazinones: novel positive inotropic agents for the treatment of conges... J Med Chem. 1984 Sep;27(9):1099-101. DMWTFO3 RU https://pubmed.ncbi.nlm.nih.gov/6471063 DMWTFO3 DI DMWTFO3 DMWTFO3 DN IMAZODAN DMWTFO3 MI TT06AWU DMWTFO3 MN Phosphodiesterase 3A (PDE3A) DMWTFO3 MT DTT DMWTFO3 MA Inhibitor DMWTFO3 RN 3,4-Dihydroquinolin-2(1H)-ones as combined inhibitors of thromboxane A2 synthase and cAMP phosphodiesterase. J Med Chem. 1992 Feb 21;35(4):620-8. DMWTFO3 RU https://pubmed.ncbi.nlm.nih.gov/1311763 DMWTFO3 DI DMWTFO3 DMWTFO3 DN IMAZODAN DMWTFO3 MI TTJ0IQB DMWTFO3 MN Phosphodiesterase 5A (PDE5A) DMWTFO3 MT DTT DMWTFO3 MA Inhibitor DMWTFO3 RN Cardiotonic agents. 1. 4,5-Dihydro-6-[4-(1H-imidazol-1-yl)phenyl]-3 (2H)-pyridazinones: novel positive inotropic agents for the treatment of conges... J Med Chem. 1984 Sep;27(9):1099-101. DMWTFO3 RU https://pubmed.ncbi.nlm.nih.gov/6471063 DMW39DV DI DMW39DV DMW39DV DN INCB3344 DMW39DV MI TTFZYTO DMW39DV MN C-C chemokine receptor type 2 (CCR2) DMW39DV MT DTT DMW39DV MA Antagonist DMW39DV RN Discovery of ((1S,3R)-1-isopropyl-3-((3S,4S)-3-methoxy-tetrahydro-2H-pyran-4-ylamino)cyclopentyl)(4-(5-(trifluoromethyl)pyridazin-3-yl)piperazin-1-yl)methanone, PF-4254196, a CCR2 antagonist with an improved cardiovascular profile. Bioorg Med Chem Lett. 2011 May 1;21(9):2626-30. DMW39DV RU https://pubmed.ncbi.nlm.nih.gov/21315584 DMODQW0 DI DMODQW0 DMODQW0 DN INXC-ICAM1 DMODQW0 MI TTA1L39 DMODQW0 MN ICAM1 messenger RNA (ICAM1 mRNA) DMODQW0 MT DTT DMODQW0 RN ISIS 2302. INXC ICAM1, Oligo-TCS. Drugs R D. 1999 Jan;1(1):85-6. DMODQW0 RU https://pubmed.ncbi.nlm.nih.gov/10565996 DMY3BMC DI DMY3BMC DMY3BMC DN IPH-3102 DMY3BMC MI TTD24Y0 DMY3BMC MN Toll-like receptor 3 (TLR3) DMY3BMC MT DTT DMY3BMC MA Agonist DMY3BMC RN Trial Watch: Experimental Toll-like receptor agonists for cancer therapy. Oncoimmunology. 2012 August 1; 1(5): 699-716. DMY3BMC RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3429574/ DM7J8IO DI DM7J8IO DM7J8IO DN IPH-3201 DM7J8IO MI TTRJ1K4 DM7J8IO MN Toll-like receptor 7 (TLR7) DM7J8IO MT DTT DM7J8IO MA Modulator DM7J8IO RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1757). DM7J8IO RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1757 DMRVZMX DI DMRVZMX DMRVZMX DN IPH-4201 DMRVZMX MI TTBFHXC DMRVZMX MN Feto-acinar pancreatic protein (FAPP) DMRVZMX MT DTT DMRVZMX RN Clinical pipeline report, company report or official report of Gimv. DMRVZMX RU http://www.gimv.com/nl/media-en-nieuws/persberichten/innate-pharma-announces-the-entry-into-pre-clinical-validation-of-iph-4201-a-new-monoclonal-antibody-targeting-pancreatic-cancer-745404 DMEJU1L DI DMEJU1L DMEJU1L DN Ipsapirone DMEJU1L MI TTSQIFT DMEJU1L MN 5-HT 1A receptor (HTR1A) DMEJU1L MT DTT DMEJU1L MA Agonist DMEJU1L RN Chronic voluntary ethanol intake hypersensitizes 5-HT(1A) autoreceptors in C57BL/6J mice. J Neurochem. 2008 Dec;107(6):1660-70. DMEJU1L RU https://pubmed.ncbi.nlm.nih.gov/19094059 DMYCPFU DI DMYCPFU DMYCPFU DN IQM-95333 DMYCPFU MI TTCG0AL DMYCPFU MN Cholecystokinin receptor type A (CCKAR) DMYCPFU MT DTT DMYCPFU MA Inhibitor DMYCPFU RN Synthesis and stereochemical structure-activity relationships of 1,3-dioxoperhydropyrido[1,2-c]pyrimidine derivatives: potent and selective cholecy... J Med Chem. 1997 Oct 10;40(21):3402-7. DMYCPFU RU https://pubmed.ncbi.nlm.nih.gov/9341915 DMYCPFU DI DMYCPFU DMYCPFU DN IQM-95333 DMYCPFU MI TTVFO0U DMYCPFU MN Gastrin/cholecystokinin type B receptor (CCKBR) DMYCPFU MT DTT DMYCPFU MA Inhibitor DMYCPFU RN Synthesis and stereochemical structure-activity relationships of 1,3-dioxoperhydropyrido[1,2-c]pyrimidine derivatives: potent and selective cholecy... J Med Chem. 1997 Oct 10;40(21):3402-7. DMYCPFU RU https://pubmed.ncbi.nlm.nih.gov/9341915 DMJ3ZUN DI DMJ3ZUN DMJ3ZUN DN Irindalone DMJ3ZUN MI TT3ROYC DMJ3ZUN MN Serotonin transporter (SERT) DMJ3ZUN MT DTT DMJ3ZUN MA Inhibitor DMJ3ZUN RN Antihypertensive activity in a series of 1-piperazino-3-phenylindans with potent 5-HT2-antagonistic activity. J Med Chem. 1988 Dec;31(12):2247-56. DMJ3ZUN RU https://pubmed.ncbi.nlm.nih.gov/2903929 DMH6K7N DI DMH6K7N DMH6K7N DN IRL-2500 DMH6K7N MI TT3ZTGU DMH6K7N MN Endothelin B receptor (EDNRB) DMH6K7N MT DTT DMH6K7N MA Inhibitor DMH6K7N RN IRL 2500: A potent ETB selective endothelin antagonist, Bioorg. Med. Chem. Lett. 6(19):2323-2328 (1996). DMH6K7N RU http://www.sciencedirect.com/science/article/pii/0960894X96004210 DMD6SXO DI DMD6SXO DMD6SXO DN ISIS-1082 DMD6SXO MI TT84ETX DMD6SXO MN Human immunodeficiency virus Reverse transcriptase (HIV RT) DMD6SXO MT DTT DMD6SXO MA Modulator DMD6SXO RN Comparison of the toxicity profiles of ISIS 1082 and ISIS 2105, phosphorothioate oligonucleotides, following subacute intradermal administration in Sprague-Dawley rats. Toxicology. 1997 Jan 15;116(1-3):77-88. DMD6SXO RU https://pubmed.ncbi.nlm.nih.gov/9020509 DM4YJ2W DI DM4YJ2W DM4YJ2W DN Isomazole DM4YJ2W MI TTUST1O DM4YJ2W MN Phosphodiesterase (PDE) DM4YJ2W MT DTT DM4YJ2W MA Inhibitor DM4YJ2W RN Effects of isomazole on force of contraction and phosphodiesterase isoenzymes I-IV in nonfailing and failing human hearts. J Cardiovasc Pharmacol. 1991 Sep;18(3):386-97. DM4YJ2W RU https://pubmed.ncbi.nlm.nih.gov/1720839 DMU5TGC DI DMU5TGC DMU5TGC DN JSM-10292 DMU5TGC MI TTGY8IW DMU5TGC MN B2 bradykinin receptor (BDKRB2) DMU5TGC MT DTT DMU5TGC MA Antagonist DMU5TGC RN Binding characteristics of [3H]-JSM10292: a new cell membrane-permeant non-peptide bradykinin B2 receptor antagonist. Br J Pharmacol. 2012 Oct;167(4):839-53. DMU5TGC RU https://pubmed.ncbi.nlm.nih.gov/22646218 DMG7B61 DI DMG7B61 DMG7B61 DN JTP-2724 DMG7B61 MI TTB2MXP DMG7B61 MN Angiotensinogenase renin (REN) DMG7B61 MT DTT DMG7B61 MA Inhibitor DMG7B61 RN Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800010026) DMG7B61 RU http://adisinsight.springer.com/drugs/800010026 DM6TXKR DI DM6TXKR DM6TXKR DN JTP-4761 DM6TXKR MI TTB2MXP DM6TXKR MN Angiotensinogenase renin (REN) DM6TXKR MT DTT DM6TXKR MA Inhibitor DM6TXKR RN Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800005981) DM6TXKR RU http://adisinsight.springer.com/drugs/800005981 DM48HVI DI DM48HVI DM48HVI DN JTT-551 DM48HVI MI TTMS7KP DM48HVI MN Protein-tyrosine phosphatase 1B (PTP1B) DM48HVI MT DTT DM48HVI MA Inhibitor DM48HVI RN Pharmacological effects of JTT-551, a novel protein tyrosine phosphatase 1B inhibitor, in diet-induced obesity mice. J Diabetes Res. 2014;2014:680348. DM48HVI RU https://pubmed.ncbi.nlm.nih.gov/24987707 DMZBNHC DI DMZBNHC DMZBNHC DN JTT-608 DMZBNHC MI TTUST1O DMZBNHC MN Phosphodiesterase (PDE) DMZBNHC MT DTT DMZBNHC MA Inhibitor DMZBNHC RN JTT-608 controls blood glucose by enhancement of glucose-stimulated insulin secretion in normal and diabetes mellitus rats. Eur J Pharmacol. 1999 Feb 12;367(1):91-9. DMZBNHC RU https://pubmed.ncbi.nlm.nih.gov/10082270 DM89TXB DI DM89TXB DM89TXB DN JTV-605 DM89TXB MI TT4TFGN DM89TXB MN Vasopressin V1a receptor (V1AR) DM89TXB MT DTT DM89TXB MA Antagonist DM89TXB RN Nonpeptide vasopressin receptor antagonists: development of selective and orally active V1a, V2 and V1b receptor ligands. Prog Brain Res. 2002;139:197-210. DM89TXB RU https://pubmed.ncbi.nlm.nih.gov/12436936 DM89TXB DI DM89TXB DM89TXB DN JTV-605 DM89TXB MI TTK8R02 DM89TXB MN Vasopressin V2 receptor (V2R) DM89TXB MT DTT DM89TXB MA Antagonist DM89TXB RN Nonpeptide vasopressin receptor antagonists: development of selective and orally active V1a, V2 and V1b receptor ligands. Prog Brain Res. 2002;139:197-210. DM89TXB RU https://pubmed.ncbi.nlm.nih.gov/12436936 DM0MXWC DI DM0MXWC DM0MXWC DN KA-398 DM0MXWC MI TTTIBOJ DM0MXWC MN Histamine H1 receptor (H1R) DM0MXWC MT DTT DM0MXWC MA Modulator DM0MXWC RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 262). DM0MXWC RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=262 DM2LFYD DI DM2LFYD DM2LFYD DN KB-5246 DM2LFYD MI TTN6J5F DM2LFYD MN Bacterial DNA gyrase (Bact gyrase) DM2LFYD MT DTT DM2LFYD MA Modulator DM2LFYD RN Activity of KB-5246 against outer membrane mutants of Escherichia coli and Salmonella typhimurium.. Antimicrob Agents Chemother. 1990 July; 34(7): 1323-1325. DM2LFYD RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC175974/ DMM7S3V DI DMM7S3V DMM7S3V DN KB-5359 DMM7S3V MI TTQWUPT DMM7S3V MN Thyroid hormone receptor (THR) DMM7S3V MT DTT DMM7S3V MA Modulator DMM7S3V RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. DMM7S3V RU https://www.fda.gov/ DM3H90W DI DM3H90W DM3H90W DN KC-11404 DM3H90W MI TT2J34L DM3H90W MN Arachidonate 5-lipoxygenase (5-LOX) DM3H90W MT DTT DM3H90W MA Modulator DM3H90W RN Synthesis, structure-activity relationships, and pharmacological evaluation of pyrrolo[3,2,1-ij]quinoline derivatives: potent histamine and platelet activating factor antagonism and 5-lipoxygenase inhibitory properties. Potential therapeutic application in asthma. J Med Chem. 1995 Feb 17;38(4):669-85. DM3H90W RU https://pubmed.ncbi.nlm.nih.gov/7861415 DM3H90W DI DM3H90W DM3H90W DN KC-11404 DM3H90W MI TTQL5VC DM3H90W MN Platelet-activating factor receptor (PTAFR) DM3H90W MT DTT DM3H90W MA Modulator DM3H90W RN Synthesis, structure-activity relationships, and pharmacological evaluation of pyrrolo[3,2,1-ij]quinoline derivatives: potent histamine and platelet activating factor antagonism and 5-lipoxygenase inhibitory properties. Potential therapeutic application in asthma. J Med Chem. 1995 Feb 17;38(4):669-85. DM3H90W RU https://pubmed.ncbi.nlm.nih.gov/7861415 DMC295V DI DMC295V DMC295V DN KC-11425 DMC295V MI TT2J34L DMC295V MN Arachidonate 5-lipoxygenase (5-LOX) DMC295V MT DTT DMC295V MA Antagonist DMC295V RN WO patent application no. 2002,01223,5, 1,4-dihydropyridines as bradykinin antagonists. DMC295V RU https://www.google.com/patents/WO2002012235A1?cl=en&hl=zh-CN DMC295V DI DMC295V DMC295V DN KC-11425 DMC295V MI TTQL5VC DMC295V MN Platelet-activating factor receptor (PTAFR) DMC295V MT DTT DMC295V MA Antagonist DMC295V RN WO patent application no. 2002,01223,5, 1,4-dihydropyridines as bradykinin antagonists. DMC295V RU https://www.google.com/patents/WO2002012235A1?cl=en&hl=zh-CN DMD0FNH DI DMD0FNH DMD0FNH DN KC-399 DMD0FNH MI TT1VOHK DMD0FNH MN Potassium channel unspecific (KC) DMD0FNH MT DTT DMD0FNH MA Opener DMD0FNH RN Action of KC-399, a newly synthesized potassium channel opener, on mechanical activity and 86Rb efflux in rat aorta. J Cardiovasc Pharmacol. 1994 Feb;23(2):220-6. DMD0FNH RU https://pubmed.ncbi.nlm.nih.gov/7511750 DMNZ1LR DI DMNZ1LR DMNZ1LR DN KF-15766 DMNZ1LR MI TT7CXIM DMNZ1LR MN Histamine receptor (HR) DMNZ1LR MT DTT DMNZ1LR MA Modulator DMNZ1LR RN Mutational analysis of the antagonist-binding site of the histamine H(1) receptor. J Biol Chem. 1999 Oct 15;274(42):29994-30000. DMNZ1LR RU https://pubmed.ncbi.nlm.nih.gov/10514483 DMQXPJB DI DMQXPJB DMQXPJB DN Ki-1769 DMQXPJB MI TT1VOHK DMQXPJB MN Potassium channel unspecific (KC) DMQXPJB MT DTT DMQXPJB MA Opener DMQXPJB RN Vasorelaxant action of Ki1769, a new pyridinecarboximidamide, in isolated porcine coronary artery. Eur J Pharmacol. 1993 Sep 14;241(2-3):177-81. DMQXPJB RU https://pubmed.ncbi.nlm.nih.gov/8243553 DMXZNB2 DI DMXZNB2 DMXZNB2 DN KNI-102 DMXZNB2 MI TT5FNQT DMXZNB2 MN Human immunodeficiency virus Protease (HIV PR) DMXZNB2 MT DTT DMXZNB2 MA Modulator DMXZNB2 RN KNI-102, a novel tripeptide HIV protease inhibitor containing allophenylnorstatine as a transition-state mimic. Chem Pharm Bull (Tokyo). 1991 Nov;39(11):3088-90. DMXZNB2 RU https://pubmed.ncbi.nlm.nih.gov/1799953 DMXT2SL DI DMXT2SL DMXT2SL DN KRG-3332 DMXT2SL MI TTNGILX DMXT2SL MN Adrenergic receptor alpha-1A (ADRA1A) DMXT2SL MT DTT DMXT2SL MA Antagonist DMXT2SL RN The beta-adrenoceptor. Am J Respir Crit Care Med. 1998 Nov;158(5 Pt 3):S146-53. DMXT2SL RU https://pubmed.ncbi.nlm.nih.gov/9817738 DM2L0VF DI DM2L0VF DM2L0VF DN KRH-2731 DM2L0VF MI TTBID49 DM2L0VF MN C-X-C chemokine receptor type 4 (CXCR4) DM2L0VF MT DTT DM2L0VF MA Binder DM2L0VF RN Progress in targeting HIV-1 entry. Drug Discov Today. 2005 Aug 15;10(16):1085-94. DM2L0VF RU https://pubmed.ncbi.nlm.nih.gov/16182193 DM4QHNG DI DM4QHNG DM4QHNG DN KRI-1314 DM4QHNG MI TTB2MXP DM4QHNG MN Angiotensinogenase renin (REN) DM4QHNG MT DTT DM4QHNG MA Inhibitor DM4QHNG RN KRI-1314: an orally effective inhibitor of human renin. Jpn J Pharmacol. 1993 Sep;63(1):109-19. DM4QHNG RU https://pubmed.ncbi.nlm.nih.gov/8271523 DMVZSAM DI DMVZSAM DMVZSAM DN KRP-105 DMVZSAM MI TTJ584C DMVZSAM MN Peroxisome proliferator-activated receptor alpha (PPARA) DMVZSAM MT DTT DMVZSAM MA Agonist DMVZSAM RN Discovery of cyclic amine-substituted benzoic acids as PPARalpha agonists. Bioorg Med Chem Lett. 2012 Jan 1;22(1):334-8. DMVZSAM RU https://pubmed.ncbi.nlm.nih.gov/22133631 DM8VMJ3 DI DM8VMJ3 DM8VMJ3 DN KT-95 DM8VMJ3 MI TTQW87Y DM8VMJ3 MN Opioid receptor kappa (OPRK1) DM8VMJ3 MT DTT DM8VMJ3 MA Modulator DM8VMJ3 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 318). DM8VMJ3 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=318 DMS2KEG DI DMS2KEG DMS2KEG DN KW-3433 DMS2KEG MI TTGN1ZA DMS2KEG MN Angiotensin II receptor (AGTR) DMS2KEG MT DTT DMS2KEG MA Modulator DMS2KEG RN Effects of various antihypertensive drugs on the function of osteoblast. Biol Pharm Bull. 2001 Jun;24(6):628-33. DMS2KEG RU https://pubmed.ncbi.nlm.nih.gov/11411549 DMQ4LDB DI DMQ4LDB DMQ4LDB DN L-158809 DMQ4LDB MI TT8DBY3 DMQ4LDB MN Angiotensin II receptor type-1 (AGTR1) DMQ4LDB MT DTT DMQ4LDB MA Antagonist DMQ4LDB RN Characterization of the binding of [3H]L-158,809: a new potent and selective nonpeptide angiotensin II receptor (AT1) antagonist radioligand. Mol Pharmacol. 1992 Dec;42(6):1077-82. DMQ4LDB RU https://pubmed.ncbi.nlm.nih.gov/1480133 DMQ4LDB DI DMQ4LDB DMQ4LDB DN L-158809 DMQ4LDB MI TTQVOEI DMQ4LDB MN Angiotensin II receptor type-2 (AGTR2) DMQ4LDB MT DTT DMQ4LDB MA Inhibitor DMQ4LDB RN Subtituted phenylthiophene benzoylsulfonamides with potent binding affinity to angiotensin II AT1 and AT2 receptors, Bioorg. Med. Chem. Lett. 4(1):189-194 (1994). DMQ4LDB RU http://www.sciencedirect.com/science/article/pii/S0960894X01811458 DM9JE7Y DI DM9JE7Y DM9JE7Y DN L-159689 DM9JE7Y MI TT8DBY3 DM9JE7Y MN Angiotensin II receptor type-1 (AGTR1) DM9JE7Y MT DTT DM9JE7Y MA Inhibitor DM9JE7Y RN Designed multiple ligands. An emerging drug discovery paradigm. J Med Chem. 2005 Oct 20;48(21):6523-43. DM9JE7Y RU https://pubmed.ncbi.nlm.nih.gov/16220969 DM9JE7Y DI DM9JE7Y DM9JE7Y DN L-159689 DM9JE7Y MI TTQVOEI DM9JE7Y MN Angiotensin II receptor type-2 (AGTR2) DM9JE7Y MT DTT DM9JE7Y MA Inhibitor DM9JE7Y RN The design, binding affinity prediction and synthesis of macrocyclic angiotensin II AT1 and AT2 receptor antagonists, Bioorg. Med. Chem. Lett. 6(8):923-928 (1996). DM9JE7Y RU http://www.sciencedirect.com/science/article/pii/0960894X96001163 DMYSEBK DI DMYSEBK DMYSEBK DN L-162234 DMYSEBK MI TTQVOEI DMYSEBK MN Angiotensin II receptor type-2 (AGTR2) DMYSEBK MT DTT DMYSEBK MA Inhibitor DMYSEBK RN Quantized surface complementarity diversity (QSCD): a model based on small molecule-target complementarity. J Med Chem. 2000 May 18;43(10):1993-2006. DMYSEBK RU https://pubmed.ncbi.nlm.nih.gov/10821712 DMYB5RV DI DMYB5RV DMYB5RV DN L-163017 DMYB5RV MI TTGN1ZA DMYB5RV MN Angiotensin II receptor (AGTR) DMYB5RV MT DTT DMYB5RV MA Modulator DMYB5RV RN In vivo pharmacology of an angiotensin AT1 receptor antagonist with balanced affinity for AT2 receptors. Eur J Pharmacol. 1995 Dec 29;294(2-3):439-50. DMYB5RV RU https://pubmed.ncbi.nlm.nih.gov/8750704 DMCRQTH DI DMCRQTH DMCRQTH DN L-371257 DMCRQTH MI TTSCIUP DMCRQTH MN Oxytocin receptor (OTR) DMCRQTH MT DTT DMCRQTH MA Inhibitor DMCRQTH RN Oral oxytocin antagonists. J Med Chem. 2010 Sep 23;53(18):6525-38. DMCRQTH RU https://pubmed.ncbi.nlm.nih.gov/20550119 DMCRQTH DI DMCRQTH DMCRQTH DN L-371257 DMCRQTH MI TT4TFGN DMCRQTH MN Vasopressin V1a receptor (V1AR) DMCRQTH MT DTT DMCRQTH MA Inhibitor DMCRQTH RN Oral oxytocin antagonists. J Med Chem. 2010 Sep 23;53(18):6525-38. DMCRQTH RU https://pubmed.ncbi.nlm.nih.gov/20550119 DMOKZ2V DI DMOKZ2V DMOKZ2V DN L-373890 DMOKZ2V MI TT6L509 DMOKZ2V MN Coagulation factor IIa (F2) DMOKZ2V MT DTT DMOKZ2V MA Inhibitor DMOKZ2V RN L-374,087, an efficacious, orally bioavailable, pyridinone acetamide thrombin inhibitor. Bioorg Med Chem Lett. 1998 Apr 7;8(7):817-22. DMOKZ2V RU https://pubmed.ncbi.nlm.nih.gov/9871547 DMK2QW0 DI DMK2QW0 DMK2QW0 DN L-374,087 DMK2QW0 MI TT6L509 DMK2QW0 MN Coagulation factor IIa (F2) DMK2QW0 MT DTT DMK2QW0 MA Inhibitor DMK2QW0 RN Pharmacological intervention at disparate sites in the coagulation cascade: comparison of anti-thrombotic efficacy vs bleeding propensity in a rat model of acute arterial thrombosis. J Thromb Thrombolysis. 2002 Oct;14(2):113-21. DMK2QW0 RU https://pubmed.ncbi.nlm.nih.gov/12714830 DMTKCNJ DI DMTKCNJ DMTKCNJ DN L-648051 DMTKCNJ MI TTGKOY9 DMTKCNJ MN Leukotriene CysLT1 receptor (CYSLTR1) DMTKCNJ MT DTT DMTKCNJ MA Modulator DMTKCNJ RN Effects of a leukotriene D4 receptor antagonist, L-648,051, and a dual inhibitor lypoxygenase and cyclooxygenase, BW-755C, on digoxin-induced arrhy... Arch Int Pharmacodyn Ther. 1993 Jan-Feb;321:72-80. DMTKCNJ RU https://www.ncbi.nlm.nih.gov/pubmed/8391788 DMGX3MK DI DMGX3MK DMGX3MK DN L-655240 DMGX3MK MI TTYLQ8V DMGX3MK MN Prostaglandin E synthase (PTGES) DMGX3MK MT DTT DMGX3MK MA Inhibitor DMGX3MK RN Inhibitors of the inducible microsomal prostaglandin E2 synthase (mPGES-1) derived from MK-886. Bioorg Med Chem Lett. 2005 Jul 15;15(14):3352-5. DMGX3MK RU https://pubmed.ncbi.nlm.nih.gov/15953724 DMOTY3G DI DMOTY3G DMOTY3G DN L-657925 DMOTY3G MI TT2O84V DMOTY3G MN Thromboxane A2 receptor (TBXA2R) DMOTY3G MT DTT DMOTY3G MA Inhibitor DMOTY3G RN Novel synthesis and biochemical properties of an [125I]-labeled photoaffinity probe for thromboxane A2/prostaglandin H2 receptors. J Med Chem. 1991 Apr;34(4):1511-4. DMOTY3G RU https://pubmed.ncbi.nlm.nih.gov/1826745 DMLENQ7 DI DMLENQ7 DMLENQ7 DN L-659989 DMLENQ7 MI TTQL5VC DMLENQ7 MN Platelet-activating factor receptor (PTAFR) DMLENQ7 MT DTT DMLENQ7 MA Inhibitor DMLENQ7 RN Development, synthesis, and biological evaluation of (-)-trans-(2S,5S)-2-[3-[(2-oxopropyl)sulfonyl]-4-n-propoxy-5-(3- hydroxypropoxy)-phenyl]-5-(3,... J Med Chem. 1992 Sep 18;35(19):3474-82. DMLENQ7 RU https://pubmed.ncbi.nlm.nih.gov/1404229 DM56VPY DI DM56VPY DM56VPY DN L-687414 DM56VPY MI TTLD29N DM56VPY MN Glutamate receptor ionotropic NMDA 1 (NMDAR1) DM56VPY MT DTT DM56VPY MA Inhibitor DM56VPY RN Amino acid bioisosteres: design of 2-quinolone derivatives as glycine-site N-methyl-D-aspartate receptor antagonists, Bioorg. Med. Chem. Lett. 3(2):299-304 (1993). DM56VPY RU http://www.sciencedirect.com/science/article/pii/S0960894X01808970 DM56VPY DI DM56VPY DM56VPY DN L-687414 DM56VPY MI TTKJEMQ DM56VPY MN Glutamate receptor ionotropic NMDA 2A (NMDAR2A) DM56VPY MT DTT DM56VPY MA Inhibitor DM56VPY RN Amino acid bioisosteres: design of 2-quinolone derivatives as glycine-site N-methyl-D-aspartate receptor antagonists, Bioorg. Med. Chem. Lett. 3(2):299-304 (1993). DM56VPY RU http://www.sciencedirect.com/science/article/pii/S0960894X01808970 DM56VPY DI DM56VPY DM56VPY DN L-687414 DM56VPY MI TTN9D8E DM56VPY MN Glutamate receptor ionotropic NMDA 2B (NMDAR2B) DM56VPY MT DTT DM56VPY MA Inhibitor DM56VPY RN Amino acid bioisosteres: design of 2-quinolone derivatives as glycine-site N-methyl-D-aspartate receptor antagonists, Bioorg. Med. Chem. Lett. 3(2):299-304 (1993). DM56VPY RU http://www.sciencedirect.com/science/article/pii/S0960894X01808970 DMCVY4U DI DMCVY4U DMCVY4U DN L-689560 DMCVY4U MI TTLD29N DMCVY4U MN Glutamate receptor ionotropic NMDA 1 (NMDAR1) DMCVY4U MT DTT DMCVY4U MA Antagonist DMCVY4U RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 455). DMCVY4U RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=455 DMCVY4U DI DMCVY4U DMCVY4U DN L-689560 DMCVY4U MI TTKJEMQ DMCVY4U MN Glutamate receptor ionotropic NMDA 2A (NMDAR2A) DMCVY4U MT DTT DMCVY4U MA Antagonist DMCVY4U RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 456). DMCVY4U RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=456 DMCVY4U DI DMCVY4U DMCVY4U DN L-689560 DMCVY4U MI TTN9D8E DMCVY4U MN Glutamate receptor ionotropic NMDA 2B (NMDAR2B) DMCVY4U MT DTT DMCVY4U MA Antagonist DMCVY4U RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 457). DMCVY4U RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=457 DMCVY4U DI DMCVY4U DMCVY4U DN L-689560 DMCVY4U MI TT1M8OW DMCVY4U MN Glutamate receptor ionotropic NMDA 2C (GluN2C) DMCVY4U MT DTT DMCVY4U MA Antagonist DMCVY4U RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 458). DMCVY4U RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=458 DMCVY4U DI DMCVY4U DMCVY4U DN L-689560 DMCVY4U MI TT5POTG DMCVY4U MN Glutamate receptor ionotropic NMDA 2D (GluN2D) DMCVY4U MT DTT DMCVY4U MA Antagonist DMCVY4U RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 459). DMCVY4U RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=459 DMCVY4U DI DMCVY4U DMCVY4U DN L-689560 DMCVY4U MI TT9IK2Z DMCVY4U MN N-methyl-D-aspartate receptor (NMDAR) DMCVY4U MT DTT DMCVY4U MA Modulator DMCVY4U RN Characterization of the binding of [3H]L-689,560, an antagonist for the glycine site on the N-methyl-D-aspartate receptor, to rat brain membranes. Mol Pharmacol. 1992 May;41(5):923-30. DMCVY4U RU https://pubmed.ncbi.nlm.nih.gov/1375318 DM2F4GT DI DM2F4GT DM2F4GT DN L-694247 DM2F4GT MI TT6MSOK DM2F4GT MN 5-HT 1D receptor (HTR1D) DM2F4GT MT DTT DM2F4GT MA Agonist DM2F4GT RN L-694,247: a potent 5-HT1D receptor agonist. Br J Pharmacol. 1993 Nov;110(3):1196-200. DM2F4GT RU https://pubmed.ncbi.nlm.nih.gov/8298808 DMT1DNS DI DMT1DNS DMT1DNS DN L-695902 DMT1DNS MI TTLD29N DMT1DNS MN Glutamate receptor ionotropic NMDA 1 (NMDAR1) DMT1DNS MT DTT DMT1DNS MA Inhibitor DMT1DNS RN Amino acid bioisosteres: design of 2-quinolone derivatives as glycine-site N-methyl-D-aspartate receptor antagonists, Bioorg. Med. Chem. Lett. 3(2):299-304 (1993). DMT1DNS RU http://www.sciencedirect.com/science/article/pii/S0960894X01808970 DMT1DNS DI DMT1DNS DMT1DNS DN L-695902 DMT1DNS MI TTKJEMQ DMT1DNS MN Glutamate receptor ionotropic NMDA 2A (NMDAR2A) DMT1DNS MT DTT DMT1DNS MA Inhibitor DMT1DNS RN Amino acid bioisosteres: design of 2-quinolone derivatives as glycine-site N-methyl-D-aspartate receptor antagonists, Bioorg. Med. Chem. Lett. 3(2):299-304 (1993). DMT1DNS RU http://www.sciencedirect.com/science/article/pii/S0960894X01808970 DMT1DNS DI DMT1DNS DMT1DNS DN L-695902 DMT1DNS MI TTN9D8E DMT1DNS MN Glutamate receptor ionotropic NMDA 2B (NMDAR2B) DMT1DNS MT DTT DMT1DNS MA Inhibitor DMT1DNS RN Amino acid bioisosteres: design of 2-quinolone derivatives as glycine-site N-methyl-D-aspartate receptor antagonists, Bioorg. Med. Chem. Lett. 3(2):299-304 (1993). DMT1DNS RU http://www.sciencedirect.com/science/article/pii/S0960894X01808970 DMV785R DI DMV785R DMV785R DN L-696418 DMV785R MI TTMX39J DMV785R MN Matrix metalloproteinase-1 (MMP-1) DMV785R MT DTT DMV785R MA Inhibitor DMV785R RN Inhibition of matrix metalloproteinases by N-carboxyalkyl peptides containing extended alkyl residues At P1', Bioorg. Med. Chem. Lett. 5(6):539-542 (1995). DMV785R RU http://www.sciencedirect.com/science/article/pii/0960894X95000799 DMV785R DI DMV785R DMV785R DN L-696418 DMV785R MI TTLM12X DMV785R MN Matrix metalloproteinase-2 (MMP-2) DMV785R MT DTT DMV785R MA Inhibitor DMV785R RN Inhibition of matrix metalloproteinases by N-carboxyalkyl peptides containing extended alkyl residues At P1', Bioorg. Med. Chem. Lett. 5(6):539-542 (1995). DMV785R RU http://www.sciencedirect.com/science/article/pii/0960894X95000799 DMV785R DI DMV785R DMV785R DN L-696418 DMV785R MI TTUZ2L5 DMV785R MN Matrix metalloproteinase-3 (MMP-3) DMV785R MT DTT DMV785R MA Inhibitor DMV785R RN Inhibition of matrix metalloproteinases by N-carboxyalkyl peptides containing extended alkyl residues At P1', Bioorg. Med. Chem. Lett. 5(6):539-542 (1995). DMV785R RU http://www.sciencedirect.com/science/article/pii/0960894X95000799 DMO9HM7 DI DMO9HM7 DMO9HM7 DN L-698532 DMO9HM7 MI TTLD29N DMO9HM7 MN Glutamate receptor ionotropic NMDA 1 (NMDAR1) DMO9HM7 MT DTT DMO9HM7 MA Inhibitor DMO9HM7 RN Synthesis of thieno[2,3-b]pyridinones acting as cytoprotectants and as inhibitors of [3H]glycine binding to the N-methyl-D-aspartate (NMDA) receptor. J Med Chem. 2006 Feb 9;49(3):864-71. DMO9HM7 RU https://pubmed.ncbi.nlm.nih.gov/16451052 DMO9HM7 DI DMO9HM7 DMO9HM7 DN L-698532 DMO9HM7 MI TTKJEMQ DMO9HM7 MN Glutamate receptor ionotropic NMDA 2A (NMDAR2A) DMO9HM7 MT DTT DMO9HM7 MA Inhibitor DMO9HM7 RN Synthesis of thieno[2,3-b]pyridinones acting as cytoprotectants and as inhibitors of [3H]glycine binding to the N-methyl-D-aspartate (NMDA) receptor. J Med Chem. 2006 Feb 9;49(3):864-71. DMO9HM7 RU https://pubmed.ncbi.nlm.nih.gov/16451052 DMO9HM7 DI DMO9HM7 DMO9HM7 DN L-698532 DMO9HM7 MI TTN9D8E DMO9HM7 MN Glutamate receptor ionotropic NMDA 2B (NMDAR2B) DMO9HM7 MT DTT DMO9HM7 MA Inhibitor DMO9HM7 RN Synthesis of thieno[2,3-b]pyridinones acting as cytoprotectants and as inhibitors of [3H]glycine binding to the N-methyl-D-aspartate (NMDA) receptor. J Med Chem. 2006 Feb 9;49(3):864-71. DMO9HM7 RU https://pubmed.ncbi.nlm.nih.gov/16451052 DMLRBN1 DI DMLRBN1 DMLRBN1 DN L-698544 DMLRBN1 MI TTAN6JD DMLRBN1 MN Glutamate receptor AMPA (GRIA) DMLRBN1 MT DTT DMLRBN1 MA Antagonist DMLRBN1 RN 3-Nitro-3,4-dihydro-2(1H)-quinolones. Excitatory amino acid antagonists acting at glycine-site NMDA and (RS)-alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors. J Med Chem. 1993 Oct 29;36(22):3397-408. DMLRBN1 RU https://pubmed.ncbi.nlm.nih.gov/8230130 DMLRBN1 DI DMLRBN1 DMLRBN1 DN L-698544 DMLRBN1 MI TTLD29N DMLRBN1 MN Glutamate receptor ionotropic NMDA 1 (NMDAR1) DMLRBN1 MT DTT DMLRBN1 MA Inhibitor DMLRBN1 RN Amino acid bioisosteres: design of 2-quinolone derivatives as glycine-site N-methyl-D-aspartate receptor antagonists, Bioorg. Med. Chem. Lett. 3(2):299-304 (1993). DMLRBN1 RU http://www.sciencedirect.com/science/article/pii/S0960894X01808970 DMLRBN1 DI DMLRBN1 DMLRBN1 DN L-698544 DMLRBN1 MI TTKJEMQ DMLRBN1 MN Glutamate receptor ionotropic NMDA 2A (NMDAR2A) DMLRBN1 MT DTT DMLRBN1 MA Inhibitor DMLRBN1 RN Amino acid bioisosteres: design of 2-quinolone derivatives as glycine-site N-methyl-D-aspartate receptor antagonists, Bioorg. Med. Chem. Lett. 3(2):299-304 (1993). DMLRBN1 RU http://www.sciencedirect.com/science/article/pii/S0960894X01808970 DMLRBN1 DI DMLRBN1 DMLRBN1 DN L-698544 DMLRBN1 MI TTN9D8E DMLRBN1 MN Glutamate receptor ionotropic NMDA 2B (NMDAR2B) DMLRBN1 MT DTT DMLRBN1 MA Inhibitor DMLRBN1 RN Amino acid bioisosteres: design of 2-quinolone derivatives as glycine-site N-methyl-D-aspartate receptor antagonists, Bioorg. Med. Chem. Lett. 3(2):299-304 (1993). DMLRBN1 RU http://www.sciencedirect.com/science/article/pii/S0960894X01808970 DMLRBN1 DI DMLRBN1 DMLRBN1 DN L-698544 DMLRBN1 MI TT9IK2Z DMLRBN1 MN N-methyl-D-aspartate receptor (NMDAR) DMLRBN1 MT DTT DMLRBN1 MA Modulator DMLRBN1 RN 3-Nitro-3,4-dihydro-2(1H)-quinolones. Excitatory amino acid antagonists acting at glycine-site NMDA and (RS)-alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors. J Med Chem. 1993 Oct 29;36(22):3397-408. DMLRBN1 RU https://pubmed.ncbi.nlm.nih.gov/8230130 DMAIJSX DI DMAIJSX DMAIJSX DN L-701324 DMAIJSX MI TTLD29N DMAIJSX MN Glutamate receptor ionotropic NMDA 1 (NMDAR1) DMAIJSX MT DTT DMAIJSX MA Inhibitor DMAIJSX RN Synthesis of thieno[2,3-b]pyridinones acting as cytoprotectants and as inhibitors of [3H]glycine binding to the N-methyl-D-aspartate (NMDA) receptor. J Med Chem. 2006 Feb 9;49(3):864-71. DMAIJSX RU https://pubmed.ncbi.nlm.nih.gov/16451052 DMAIJSX DI DMAIJSX DMAIJSX DN L-701324 DMAIJSX MI TTKJEMQ DMAIJSX MN Glutamate receptor ionotropic NMDA 2A (NMDAR2A) DMAIJSX MT DTT DMAIJSX MA Inhibitor DMAIJSX RN Synthesis of thieno[2,3-b]pyridinones acting as cytoprotectants and as inhibitors of [3H]glycine binding to the N-methyl-D-aspartate (NMDA) receptor. J Med Chem. 2006 Feb 9;49(3):864-71. DMAIJSX RU https://pubmed.ncbi.nlm.nih.gov/16451052 DMAIJSX DI DMAIJSX DMAIJSX DN L-701324 DMAIJSX MI TTN9D8E DMAIJSX MN Glutamate receptor ionotropic NMDA 2B (NMDAR2B) DMAIJSX MT DTT DMAIJSX MA Inhibitor DMAIJSX RN Synthesis of thieno[2,3-b]pyridinones acting as cytoprotectants and as inhibitors of [3H]glycine binding to the N-methyl-D-aspartate (NMDA) receptor. J Med Chem. 2006 Feb 9;49(3):864-71. DMAIJSX RU https://pubmed.ncbi.nlm.nih.gov/16451052 DMO7GWC DI DMO7GWC DMO7GWC DN L-702958 DMO7GWC MI TTQ6VDM DMO7GWC MN Voltage-gated potassium channel Kv11.1 (KCNH2) DMO7GWC MT DTT DMO7GWC MA Modulator DMO7GWC RN Analogs of MK-499 are differentially affected by a mutation in the S6 domain of the hERG K+ channel.Biochem Pharmacol.2009 May 15;77(10):1602-11. DMO7GWC RU https://www.ncbi.nlm.nih.gov/pubmed/19426697 DM47MKE DI DM47MKE DM47MKE DN L-703014 DM47MKE MI TT38RM1 DM47MKE MN Glycoprotein IIb/IIIa receptor (GPIIb/IIIa) DM47MKE MT DTT DM47MKE MA Modulator DM47MKE RN Pharmacokinetics and pharmacodynamics of L-703,014, a potent fibrinogen receptor antagonist, after intravenous and oral administration in the dog. Pharm Res. 1994 Mar;11(3):426-31. DM47MKE RU https://www.ncbi.nlm.nih.gov/pubmed/8008711 DMQZW6D DI DMQZW6D DMQZW6D DN L-709049 DMQZW6D MI TTCQIBE DMQZW6D MN Caspase-1 (CASP1) DMQZW6D MT DTT DMQZW6D MA Inhibitor DMQZW6D RN Succinic acid amides as P2-P3 replacements for inhibitors of interleukin-1beta converting enzyme (ICE or caspase 1). Bioorg Med Chem Lett. 2010 Sep 1;20(17):5184-90. DMQZW6D RU https://pubmed.ncbi.nlm.nih.gov/20656488 DMB3ZTI DI DMB3ZTI DMB3ZTI DN L-709780 DMB3ZTI MI TTJA1ZO DMB3ZTI MN ITGB3 messenger RNA (ITGB3 mRNA) DMB3ZTI MT DTT DMB3ZTI MA Inhibitor DMB3ZTI RN Non-peptide fibrinogen receptor antagonists. 3. design and discovery of a centrally constrained inhibitorc, Bioorg. Med. Chem. Lett. 4(15):1835-1840 (1994). DMB3ZTI RU http://www.sciencedirect.com/science/article/pii/S0960894X01803802 DM1XBKC DI DM1XBKC DM1XBKC DN L-731735 DM1XBKC MI TT7WZIJ DM1XBKC MN CAAX farnesyltransferase beta (FNTB) DM1XBKC MT DTT DM1XBKC MA Inhibitor DM1XBKC RN Ras farnesyltransferase: a new therapeutic target. J Med Chem. 1997 Sep 12;40(19):2971-90. DM1XBKC RU https://pubmed.ncbi.nlm.nih.gov/9301658 DM1XBKC DI DM1XBKC DM1XBKC DN L-731735 DM1XBKC MI TTXQKM3 DM1XBKC MN Farnesyl protein transferase (Ftase) DM1XBKC MT DTT DM1XBKC MA Inhibitor DM1XBKC RN N-Arylalkyl pseudopeptide inhibitors of farnesyltransferase. J Med Chem. 1998 Jul 2;41(14):2651-6. DM1XBKC RU https://pubmed.ncbi.nlm.nih.gov/9651171 DMVXKMF DI DMVXKMF DMVXKMF DN L-732138 DMVXKMF MI TTYO0A3 DMVXKMF MN Substance-K receptor (TACR2) DMVXKMF MT DTT DMVXKMF MA Inhibitor DMVXKMF RN Biological and conformational evaluation of bifunctional compounds for opioid receptor agonists and neurokinin 1 receptor antagonists possessing tw... J Med Chem. 2010 Aug 12;53(15):5491-501. DMVXKMF RU https://pubmed.ncbi.nlm.nih.gov/20617791 DMVXKMF DI DMVXKMF DMVXKMF DN L-732138 DMVXKMF MI TTZPO1L DMVXKMF MN Substance-P receptor (TACR1) DMVXKMF MT DTT DMVXKMF MA Inhibitor DMVXKMF RN The biological activity and metabolic stability of peptidic bifunctional compounds that are opioid receptor agonists and neurokinin-1 receptor anta... Bioorg Med Chem. 2009 Oct 15;17(20):7337-43. DMVXKMF RU https://pubmed.ncbi.nlm.nih.gov/19762245 DMA1NJW DI DMA1NJW DMA1NJW DN L-733060 DMA1NJW MI TTZPO1L DMA1NJW MN Substance-P receptor (TACR1) DMA1NJW MT DTT DMA1NJW MA Inhibitor DMA1NJW RN 3-Benzyloxy-2-phenylpiperidine NK1 antagonists: the influence of alpha methyl substitution, Bioorg. Med. Chem. Lett. 7(23):2959-2962 (1997). DMA1NJW RU http://www.sciencedirect.com/science/article/pii/S0960894X97101184 DMYZPJU DI DMYZPJU DMYZPJU DN L-733560 DMYZPJU MI TT0SFXH DMYZPJU MN Fungal 1,3-beta-glucan synthase (Fung GSC2) DMYZPJU MT DTT DMYZPJU MA Modulator DMYZPJU RN Discovery of Novel Antifungal (1,3)--d-Glucan Synthase Inhibitors DMYZPJU RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC89685 DMO69X8 DI DMO69X8 DMO69X8 DN L-738167 DMO69X8 MI TTJA1ZO DMO69X8 MN ITGB3 messenger RNA (ITGB3 mRNA) DMO69X8 MT DTT DMO69X8 MA Inhibitor DMO69X8 RN Platelet glycoprotein IIb-IIIa antagonists as prototypical integrin blockers: novel parenteral and potential oral antithrombotic agents. J Med Chem. 2000 Sep 21;43(19):3453-73. DMO69X8 RU https://pubmed.ncbi.nlm.nih.gov/10999999 DMAUG0L DI DMAUG0L DMAUG0L DN L-739749 DMAUG0L MI TT7WZIJ DMAUG0L MN CAAX farnesyltransferase beta (FNTB) DMAUG0L MT DTT DMAUG0L MA Inhibitor DMAUG0L RN Ras farnesyltransferase: a new therapeutic target. J Med Chem. 1997 Sep 12;40(19):2971-90. DMAUG0L RU https://pubmed.ncbi.nlm.nih.gov/9301658 DMNSH0V DI DMNSH0V DMNSH0V DN L-741604 DMNSH0V MI TT6MSOK DMNSH0V MN 5-HT 1D receptor (HTR1D) DMNSH0V MT DTT DMNSH0V MA Inhibitor DMNSH0V RN 3-(Piperazinylpropyl)indoles: selective, orally bioavailable h5-HT1D receptor agonists as potential antimigraine agents. J Med Chem. 1999 Feb 25;42(4):691-705. DMNSH0V RU https://pubmed.ncbi.nlm.nih.gov/10052976 DMRVXEQ DI DMRVXEQ DMRVXEQ DN L-741671 DMRVXEQ MI TTZPO1L DMRVXEQ MN Substance-P receptor (TACR1) DMRVXEQ MT DTT DMRVXEQ MA Inhibitor DMRVXEQ RN N-heteroaryl-2-phenyl-3-(benzyloxy)piperidines: a novel class of potent orally active human NK1 antagonists. J Med Chem. 1996 Jul 19;39(15):2907-14. DMRVXEQ RU https://pubmed.ncbi.nlm.nih.gov/8709125 DMOQIWH DI DMOQIWH DMOQIWH DN L-745337 DMOQIWH MI TTVKILB DMOQIWH MN Prostaglandin G/H synthase 2 (COX-2) DMOQIWH MT DTT DMOQIWH MA Modulator DMOQIWH RN Pharmacology of a selective cyclooxygenase-2 inhibitor, L-745,337: a novel nonsteroidal anti-inflammatory agent with an ulcerogenic sparing effect ... J Pharmacol Exp Ther. 1995 Sep;274(3):1531-7. DMOQIWH RU https://www.ncbi.nlm.nih.gov/pubmed/7562530 DM4UP7R DI DM4UP7R DM4UP7R DN L-745631 DM4UP7R MI TT7WZIJ DM4UP7R MN CAAX farnesyltransferase beta (FNTB) DM4UP7R MT DTT DM4UP7R MA Inhibitor DM4UP7R RN Ras farnesyltransferase: a new therapeutic target. J Med Chem. 1997 Sep 12;40(19):2971-90. DM4UP7R RU https://pubmed.ncbi.nlm.nih.gov/9301658 DM4UP7R DI DM4UP7R DM4UP7R DN L-745631 DM4UP7R MI TTXQKM3 DM4UP7R MN Farnesyl protein transferase (Ftase) DM4UP7R MT DTT DM4UP7R MA Inhibitor DM4UP7R RN Ras farnesyltransferase: a new therapeutic target. J Med Chem. 1997 Sep 12;40(19):2971-90. DM4UP7R RU https://pubmed.ncbi.nlm.nih.gov/9301658 DM4UP7R DI DM4UP7R DM4UP7R DN L-745631 DM4UP7R MI TTX20QP DM4UP7R MN Geranylgeranyl transferase I (GGTase-I) DM4UP7R MT DTT DM4UP7R MA Inhibitor DM4UP7R RN Ras farnesyltransferase: a new therapeutic target. J Med Chem. 1997 Sep 12;40(19):2971-90. DM4UP7R RU https://pubmed.ncbi.nlm.nih.gov/9301658 DMPWBNU DI DMPWBNU DMPWBNU DN L-755507 DMPWBNU MI TTR6W5O DMPWBNU MN Adrenergic receptor beta-1 (ADRB1) DMPWBNU MT DTT DMPWBNU MA Inhibitor DMPWBNU RN (4-Piperidin-1-yl)phenyl amides: potent and selective human beta(3) agonists. J Med Chem. 2001 Apr 26;44(9):1456-66. DMPWBNU RU https://pubmed.ncbi.nlm.nih.gov/11311069 DMPWBNU DI DMPWBNU DMPWBNU DN L-755507 DMPWBNU MI TT2CJVK DMPWBNU MN Adrenergic receptor beta-2 (ADRB2) DMPWBNU MT DTT DMPWBNU MA Inhibitor DMPWBNU RN (4-Piperidin-1-yl)phenyl amides: potent and selective human beta(3) agonists. J Med Chem. 2001 Apr 26;44(9):1456-66. DMPWBNU RU https://pubmed.ncbi.nlm.nih.gov/11311069 DMPWBNU DI DMPWBNU DMPWBNU DN L-755507 DMPWBNU MI TTEAID7 DMPWBNU MN Trypanosoma Cruzipain (Trypano CYSP) DMPWBNU MT DTT DMPWBNU MA Inhibitor DMPWBNU RN Quantitative analyses of aggregation, autofluorescence, and reactivity artifacts in a screen for inhibitors of a thiol protease. J Med Chem. 2010 Jan 14;53(1):37-51. DMPWBNU RU https://pubmed.ncbi.nlm.nih.gov/19908840 DM17S85 DI DM17S85 DM17S85 DN L-757464 DM17S85 MI TTNGILX DM17S85 MN Adrenergic receptor alpha-1A (ADRA1A) DM17S85 MT DTT DM17S85 MA Antagonist DM17S85 RN Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800010051) DM17S85 RU http://adisinsight.springer.com/drugs/800010051 DM7J6QH DI DM7J6QH DM7J6QH DN L-768277 DM7J6QH MI TTVKILB DM7J6QH MN Prostaglandin G/H synthase 2 (COX-2) DM7J6QH MT DTT DM7J6QH MA Modulator DM7J6QH RN Characterization of the in vitro oxidative metabolites of the COX-2 selective inhibitor L-766,112. Bioorganic & Medicinal Chemistry Letters Volume 7, Issue 1, 7 January 1997, Pages 53-56. DM7J6QH RU http://www.sciencedirect.com/science/article/pii/S0960894X96005811 DMZ402C DI DMZ402C DMZ402C DN L-768673 DMZ402C MI TT846HF DMZ402C MN Voltage-gated potassium channel Kv7.1 (KCNQ1) DMZ402C MT DTT DMZ402C MA Inhibitor DMZ402C RN Class III antiarrhythmic activity in vivo by selective blockade of the slowly activating cardiac delayed rectifier potassium current IKs by (R)-2-(... J Med Chem. 1997 Nov 21;40(24):3865-8. DMZ402C RU https://pubmed.ncbi.nlm.nih.gov/9397166 DMJ37IX DI DMJ37IX DMJ37IX DN L-775606 DMJ37IX MI TTK8CXU DMJ37IX MN 5-HT 1B receptor (HTR1B) DMJ37IX MT DTT DMJ37IX MA Inhibitor DMJ37IX RN Selective, orally active 5-HT1D receptor agonists as potential antimigraine agents. J Med Chem. 1997 Oct 24;40(22):3501-3. DMJ37IX RU https://pubmed.ncbi.nlm.nih.gov/9357515 DMJ37IX DI DMJ37IX DMJ37IX DN L-775606 DMJ37IX MI TT6MSOK DMJ37IX MN 5-HT 1D receptor (HTR1D) DMJ37IX MT DTT DMJ37IX MA Inhibitor DMJ37IX RN Designing selective, high affinity ligands of 5-HT1D receptor by covalent dimerization of 5-HT1F ligands derived from 4-fluoro-N-[3-(1-methyl-4-pip... J Med Chem. 2008 Jun 26;51(12):3609-16. DMJ37IX RU https://pubmed.ncbi.nlm.nih.gov/18507369 DM07S4N DI DM07S4N DM07S4N DN LAS-30538 DM07S4N MI TT5HONZ DM07S4N MN Calcium channel unspecific (CaC) DM07S4N MT DTT DM07S4N MA Modulator DM07S4N RN The calcium channel blocker LAS 30538, unlike nifedipine, verapamil, diltiazem or flunarizine, potently inhibits insulin secretion in-vivo in rats and dogs. J Pharm Pharmacol. 1992 Oct;44(10):851-5. DM07S4N RU https://pubmed.ncbi.nlm.nih.gov/1360513 DMW2K1L DI DMW2K1L DMW2K1L DN LAS-31180 DMW2K1L MI TT06AWU DMW2K1L MN Phosphodiesterase 3A (PDE3A) DMW2K1L MT DTT DMW2K1L MA Modulator DMW2K1L RN Pharmacological profile of LAS 31180, a new inotropic/vasodilator quinolone derivative. Arzneimittelforschung. 2000 Nov;50(11):980-6. DMW2K1L RU https://pubmed.ncbi.nlm.nih.gov/11148864 DMYGJCL DI DMYGJCL DMYGJCL DN LB30057 DMYGJCL MI TT6L509 DMYGJCL MN Coagulation factor IIa (F2) DMYGJCL MT DTT DMYGJCL MA Inhibitor DMYGJCL RN Antithrombotic activity of LB30057, a newly synthesized direct thrombin inhibitor. Thromb Haemost. 2003 Jan;89(1):104-11. DMYGJCL RU https://pubmed.ncbi.nlm.nih.gov/12540960 DMFEMTG DI DMFEMTG DMFEMTG DN Lecimibide DMFEMTG MI TTMF541 DMFEMTG MN Liver carboxylesterase (CES1) DMFEMTG MT DTT DMFEMTG MA Modulator DMFEMTG RN Effect of the acyl-CoA:cholesterol acyltransferase inhibitor DuP 128 on cholesterol absorption and serum cholesterol in humans. Clin Pharmacol Ther. 1994 Jul;56(1):65-74. DMFEMTG RU https://pubmed.ncbi.nlm.nih.gov/8033496 DMIYMS2 DI DMIYMS2 DMIYMS2 DN LF-984 DMIYMS2 MI TTP4520 DMIYMS2 MN TGF-beta receptor type I (TGFBR1) DMIYMS2 MT DTT DMIYMS2 MA Inhibitor DMIYMS2 RN US patent application no. 2013,0028,978, Compositions and methods for wound treatment. DMIYMS2 RU https://www.google.com.ar/patents/US20130028978 DMNXKR2 DI DMNXKR2 DMNXKR2 DN LG-2293 DMNXKR2 MI TTS64P2 DMNXKR2 MN Androgen receptor (AR) DMNXKR2 MT DTT DMNXKR2 MA Modulator DMNXKR2 RN Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800006840) DMNXKR2 RU http://adisinsight.springer.com/drugs/800006840 DMF9XU4 DI DMF9XU4 DMF9XU4 DN LM-1376 DMF9XU4 MI TTGKOY9 DMF9XU4 MN Leukotriene CysLT1 receptor (CYSLTR1) DMF9XU4 MT DTT DMF9XU4 MA Modulator DMF9XU4 RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. DMF9XU4 RU https://www.fda.gov/ DM6Y49D DI DM6Y49D DM6Y49D DN L-NIL DM6Y49D MI TTZUFI5 DM6Y49D MN Nitric-oxide synthase brain (NOS1) DM6Y49D MT DTT DM6Y49D MA Inhibitor DM6Y49D RN Discovery of a series of aminopiperidines as novel iNOS inhibitors. Bioorg Med Chem Lett. 2008 Jan 1;18(1):336-43. DM6Y49D RU https://pubmed.ncbi.nlm.nih.gov/18024030 DM6Y49D DI DM6Y49D DM6Y49D DN L-NIL DM6Y49D MI TTCM4B3 DM6Y49D MN Nitric-oxide synthase endothelial (NOS3) DM6Y49D MT DTT DM6Y49D MA Inhibitor DM6Y49D RN Discovery of a series of aminopiperidines as novel iNOS inhibitors. Bioorg Med Chem Lett. 2008 Jan 1;18(1):336-43. DM6Y49D RU https://pubmed.ncbi.nlm.nih.gov/18024030 DM6Y49D DI DM6Y49D DM6Y49D DN L-NIL DM6Y49D MI TTF10I9 DM6Y49D MN Nitric-oxide synthase inducible (NOS2) DM6Y49D MT DTT DM6Y49D MA Inhibitor DM6Y49D RN Discovery of a series of aminopiperidines as novel iNOS inhibitors. Bioorg Med Chem Lett. 2008 Jan 1;18(1):336-43. DM6Y49D RU https://pubmed.ncbi.nlm.nih.gov/18024030 DM904B6 DI DM904B6 DM904B6 DN Lorglumide DM904B6 MI TTCG0AL DM904B6 MN Cholecystokinin receptor type A (CCKAR) DM904B6 MT DTT DM904B6 MA Antagonist DM904B6 RN Behavioral and neurochemical study on the role of the brain cholecystokinin system in anxiety. Hokkaido Igaku Zasshi. 1998 Sep;73(5):463-73. DM904B6 RU https://pubmed.ncbi.nlm.nih.gov/9846276 DMFJPYV DI DMFJPYV DMFJPYV DN LSI-518P DMFJPYV MI TT7GN3U DMFJPYV MN Apolipoprotein A-I (APOA1) DMFJPYV MT DTT DMFJPYV MA Modulator DMFJPYV RN Clinical review: The evolving role of HDL in the treatment of high-risk patients with cardiovascular disease. J Clin Endocrinol Metab. 2011 May;96(5):1246-57. DMFJPYV RU https://pubmed.ncbi.nlm.nih.gov/21389140 DMDHLUC DI DMDHLUC DMDHLUC DN LU-29252 DMDHLUC MI TT5TPI6 DMDHLUC MN Opioid receptor sigma 1 (OPRS1) DMDHLUC MT DTT DMDHLUC MA Modulator DMDHLUC RN Involvement of sigma receptors in the modulation of the glutamatergic/NMDA neurotransmission in the dopaminergic systems. Eur J Pharmacol. 1999 Mar 5;368(2-3):183-96. DMDHLUC RU https://pubmed.ncbi.nlm.nih.gov/10193654 DMXRJQV DI DMXRJQV DMXRJQV DN Luzindole DMXRJQV MI TT0WAIE DMXRJQV MN Melatonin receptor type 1A (MTNR1A) DMXRJQV MT DTT DMXRJQV MA Modulator DMXRJQV RN Luzindole (N-0774): a novel melatonin receptor antagonist. J Pharmacol Exp Ther. 1988 Sep;246(3):902-10. DMXRJQV RU https://pubmed.ncbi.nlm.nih.gov/2843633 DMMRLPF DI DMMRLPF DMMRLPF DN LX-2932 DMMRLPF MI TT618Q2 DMMRLPF MN Sphingosine-1-phosphate lyase 1 (SGPL1) DMMRLPF MT DTT DMMRLPF MA Inhibitor DMMRLPF RN Inhibition of sphingosine 1-phosphate lyase for the treatment of rheumatoid arthritis: discovery of (E)-1-(4-((1R,2S,3R)-1,2,3,4-tetrahydroxybutyl)-1H-imidazol-2-yl)ethanone oxime (LX2931) and (1R,2S,3R)-1-(2-(isoxazol-3-yl)-1H-imidazol-4-yl)butane-1,2,3,4-tetraol (LX2932). J Med Chem. 2010 Dec 23;53(24):8650-62. DMMRLPF RU https://pubmed.ncbi.nlm.nih.gov/21090716 DMXYDJR DI DMXYDJR DMXYDJR DN LXR-015-2 DMXYDJR MI TTC8M31 DMXYDJR MN Carnitine acyltransferase (CRAT) DMXYDJR MT DTT DMXYDJR MA Inhibitor DMXYDJR RN EDG receptors as a potential therapeutic target in retinal ischemia-reperfusion injury. Brain Res. 2006 Nov 6;1118(1):168-75. DMXYDJR RU https://pubmed.ncbi.nlm.nih.gov/17026968 DMUHG0F DI DMUHG0F DMUHG0F DN LY-117018 DMUHG0F MI TTZAYWL DMUHG0F MN Estrogen receptor (ESR) DMUHG0F MT DTT DMUHG0F MA Inhibitor DMUHG0F RN Structure-activity relationship of antiestrogens. Phenolic analogues of 2,3-diaryl-2H-1-benzopyrans. J Med Chem. 1990 Dec;33(12):3222-9. DMUHG0F RU https://pubmed.ncbi.nlm.nih.gov/2258908 DMUHG0F DI DMUHG0F DMUHG0F DN LY-117018 DMUHG0F MI TTOM3J0 DMUHG0F MN Estrogen receptor beta (ESR2) DMUHG0F MT DTT DMUHG0F MA Inhibitor DMUHG0F RN Structure-activity relationship of antiestrogens. Phenolic analogues of 2,3-diaryl-2H-1-benzopyrans. J Med Chem. 1990 Dec;33(12):3222-9. DMUHG0F RU https://pubmed.ncbi.nlm.nih.gov/2258908 DMUEB4P DI DMUEB4P DMUEB4P DN LY-210073 DMUEB4P MI TTN53ZF DMUEB4P MN Leukotriene B4 receptor 1 (LTB4R) DMUEB4P MT DTT DMUEB4P MA Modulator DMUEB4P RN Design, synthesis, and pharmacological evaluation of potent xanthone dicarboxylic acid leukotriene B4 receptor antagonists. J Med Chem. 1993 Jun 11;36(12):1726-34. DMUEB4P RU https://pubmed.ncbi.nlm.nih.gov/8389876 DMJ54E9 DI DMJ54E9 DMJ54E9 DN LY-221068 DMJ54E9 MI TT2J34L DMJ54E9 MN Arachidonate 5-lipoxygenase (5-LOX) DMJ54E9 MT DTT DMJ54E9 MA Inhibitor DMJ54E9 RN Anti-inflammatory effects of LY221068 and LY269415. Agents Actions. 1991 Sep;34(1-2):100-2. DMJ54E9 RU https://pubmed.ncbi.nlm.nih.gov/1793009 DMIDK36 DI DMIDK36 DMIDK36 DN LY-243062 DMIDK36 MI TTEX248 DMIDK36 MN Dopamine D2 receptor (D2R) DMIDK36 MT DTT DMIDK36 MA Modulator DMIDK36 RN Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800005079) DMIDK36 RU http://adisinsight.springer.com/drugs/800005079 DMFIR0S DI DMFIR0S DMFIR0S DN LY-255283 DMFIR0S MI TTN53ZF DMFIR0S MN Leukotriene B4 receptor 1 (LTB4R) DMFIR0S MT DTT DMFIR0S MA Inhibitor DMFIR0S RN o-phenylphenols: potent and orally active leukotriene B4 receptor antagonists. J Med Chem. 1993 Nov 26;36(24):3978-81. DMFIR0S RU https://pubmed.ncbi.nlm.nih.gov/7902871 DMFIR0S DI DMFIR0S DMFIR0S DN LY-255283 DMFIR0S MI TTVJX54 DMFIR0S MN Leukotriene B4 receptor 2 (LTB4R2) DMFIR0S MT DTT DMFIR0S MA Inhibitor DMFIR0S RN o-phenylphenols: potent and orally active leukotriene B4 receptor antagonists. J Med Chem. 1993 Nov 26;36(24):3978-81. DMFIR0S RU https://pubmed.ncbi.nlm.nih.gov/7902871 DMG79NT DI DMG79NT DMG79NT DN LY-274614 DMG79NT MI TT9IK2Z DMG79NT MN N-methyl-D-aspartate receptor (NMDAR) DMG79NT MT DTT DMG79NT MA Modulator DMG79NT RN The NMDA receptor antagonists, LY274614 and MK-801, and the nitric oxide synthase inhibitor, NG-nitro-L-arginine, attenuate analgesic tolerance to the mu-opioid morphine but not to kappa opioids. Pain. 1994 Jan;56(1):69-75. DMG79NT RU https://pubmed.ncbi.nlm.nih.gov/7512709 DMG8YE9 DI DMG8YE9 DMG8YE9 DN LY288513 DMG8YE9 MI TTVFO0U DMG8YE9 MN Gastrin/cholecystokinin type B receptor (CCKBR) DMG8YE9 MT DTT DMG8YE9 MA Antagonist DMG8YE9 RN Behavioral and neurochemical study on the role of the brain cholecystokinin system in anxiety. Hokkaido Igaku Zasshi. 1998 Sep;73(5):463-73. DMG8YE9 RU https://pubmed.ncbi.nlm.nih.gov/9846276 DMPZ7AO DI DMPZ7AO DMPZ7AO DN LY-290154 DMPZ7AO MI TTGKOY9 DMPZ7AO MN Leukotriene CysLT1 receptor (CYSLTR1) DMPZ7AO MT DTT DMPZ7AO MA Modulator DMPZ7AO RN DOI: 10.1021/op060036x DMPZ7AO RU http://pubs.acs.org/doi/abs/10.1021/op060036x DMPZ7AO DI DMPZ7AO DMPZ7AO DN LY-290154 DMPZ7AO MI TT0PZR5 DMPZ7AO MN Leukotriene CysLT2 receptor (CYSLTR2) DMPZ7AO MT DTT DMPZ7AO MA Modulator DMPZ7AO RN DOI: 10.1021/op060036x DMPZ7AO RU http://pubs.acs.org/doi/abs/10.1021/op060036x DMU24HR DI DMU24HR DMU24HR DN LY-292728 DMU24HR MI TTN53ZF DMU24HR MN Leukotriene B4 receptor 1 (LTB4R) DMU24HR MT DTT DMU24HR MA Inhibitor DMU24HR RN Biphenylyl-substituted xanthones: highly potent leukotriene B4 receptor antagonists. J Med Chem. 1993 Nov 26;36(24):3982-4. DMU24HR RU https://pubmed.ncbi.nlm.nih.gov/8254628 DMU24HR DI DMU24HR DMU24HR DN LY-292728 DMU24HR MI TTVJX54 DMU24HR MN Leukotriene B4 receptor 2 (LTB4R2) DMU24HR MT DTT DMU24HR MA Inhibitor DMU24HR RN Biphenylyl-substituted xanthones: highly potent leukotriene B4 receptor antagonists. J Med Chem. 1993 Nov 26;36(24):3982-4. DMU24HR RU https://pubmed.ncbi.nlm.nih.gov/8254628 DMH21JG DI DMH21JG DMH21JG DN LY-293284 DMH21JG MI TTSQIFT DMH21JG MN 5-HT 1A receptor (HTR1A) DMH21JG MT DTT DMH21JG MA Agonist DMH21JG RN Pharmacological characterization of LY293284: A 5-HT1A receptor agonist with high potency and selectivity. J Pharmacol Exp Ther. 1994 Sep;270(3):1270-81. DMH21JG RU https://pubmed.ncbi.nlm.nih.gov/7523657 DMM20PI DI DMM20PI DMM20PI DN LY-317644 DMM20PI MI TTFJ8Q1 DMM20PI MN Protein kinase C alpha (PRKCA) DMM20PI MT DTT DMM20PI MA Inhibitor DMM20PI RN Synthesis of bisindolylmaleimide macrocycles, Bioorg. Med. Chem. Lett. 5(18):2093-2096 (1995). DMM20PI RU http://www.sciencedirect.com/science/article/pii/0960894X95003503 DMM20PI DI DMM20PI DMM20PI DN LY-317644 DMM20PI MI TTYPXQF DMM20PI MN Protein kinase C beta (PRKCB) DMM20PI MT DTT DMM20PI MA Inhibitor DMM20PI RN Synthesis of bisindolylmaleimide macrocycles, Bioorg. Med. Chem. Lett. 5(18):2093-2096 (1995). DMM20PI RU http://www.sciencedirect.com/science/article/pii/0960894X95003503 DMM20PI DI DMM20PI DMM20PI DN LY-317644 DMM20PI MI TT9WJ8U DMM20PI MN Protein kinase C delta (PRKCD) DMM20PI MT DTT DMM20PI MA Inhibitor DMM20PI RN Synthesis of bisindolylmaleimide macrocycles, Bioorg. Med. Chem. Lett. 5(18):2093-2096 (1995). DMM20PI RU http://www.sciencedirect.com/science/article/pii/0960894X95003503 DMM20PI DI DMM20PI DMM20PI DN LY-317644 DMM20PI MI TTBZ7OD DMM20PI MN Protein kinase C epsilon (PRKCE) DMM20PI MT DTT DMM20PI MA Inhibitor DMM20PI RN Synthesis of bisindolylmaleimide macrocycles, Bioorg. Med. Chem. Lett. 5(18):2093-2096 (1995). DMM20PI RU http://www.sciencedirect.com/science/article/pii/0960894X95003503 DMM20PI DI DMM20PI DMM20PI DN LY-317644 DMM20PI MI TTRFOXJ DMM20PI MN Protein kinase C gamma (PRKCG) DMM20PI MT DTT DMM20PI MA Inhibitor DMM20PI RN Synthesis of bisindolylmaleimide macrocycles, Bioorg. Med. Chem. Lett. 5(18):2093-2096 (1995). DMM20PI RU http://www.sciencedirect.com/science/article/pii/0960894X95003503 DMM20PI DI DMM20PI DMM20PI DN LY-317644 DMM20PI MI TT8QL1J DMM20PI MN Protein kinase C theta (PRKCQ) DMM20PI MT DTT DMM20PI MA Inhibitor DMM20PI RN Synthesis of bisindolylmaleimide macrocycles, Bioorg. Med. Chem. Lett. 5(18):2093-2096 (1995). DMM20PI RU http://www.sciencedirect.com/science/article/pii/0960894X95003503 DMM20PI DI DMM20PI DMM20PI DN LY-317644 DMM20PI MI TTUWGRA DMM20PI MN Protein kinase C zeta (PRKCZ) DMM20PI MT DTT DMM20PI MA Inhibitor DMM20PI RN Synthesis of bisindolylmaleimide macrocycles, Bioorg. Med. Chem. Lett. 5(18):2093-2096 (1995). DMM20PI RU http://www.sciencedirect.com/science/article/pii/0960894X95003503 DMFVYID DI DMFVYID DMFVYID DN LY-353433 DMFVYID MI TT07C3Y DMFVYID MN 5-HT 4 receptor (HTR4) DMFVYID MT DTT DMFVYID MA Antagonist DMFVYID RN LY353433, a potent, orally effective, long-acting 5-HT(4) receptor antagonist: comparison to cisapride and RS23597-190. J Pharmacol Exp Ther. 1996 Apr;277(1):97-104. DMFVYID RU https://pubmed.ncbi.nlm.nih.gov/8613972 DM98POQ DI DM98POQ DM98POQ DN LY-367385 DM98POQ MI TTVBPDM DM98POQ MN Metabotropic glutamate receptor 1 (mGluR1) DM98POQ MT DTT DM98POQ MA Agonist DM98POQ RN Anticonvulsant actions of LY 367385 ((+)-2-methyl-4-carboxyphenylglycine) and AIDA ((RS)-1-aminoindan-1,5-dicarboxylic acid). Eur J Pharmacol. 1999 Feb 26;368(1):17-24. DM98POQ RU https://pubmed.ncbi.nlm.nih.gov/10096765 DM0TV9L DI DM0TV9L DM0TV9L DN LY467711 DM0TV9L MI TTHS256 DM0TV9L MN Metabotropic glutamate receptor 5 (mGluR5) DM0TV9L MT DTT DM0TV9L MA Antagonist DM0TV9L RN Glutamate- and GABA-based CNS therapeutics. Curr Opin Pharmacol. 2006 Feb;6(1):7-17. DM0TV9L RU https://pubmed.ncbi.nlm.nih.gov/16377242 DMPNMAR DI DMPNMAR DMPNMAR DN LY525327 DMPNMAR MI TTHS256 DMPNMAR MN Metabotropic glutamate receptor 5 (mGluR5) DMPNMAR MT DTT DMPNMAR MA Antagonist DMPNMAR RN Glutamate- and GABA-based CNS therapeutics. Curr Opin Pharmacol. 2006 Feb;6(1):7-17. DMPNMAR RU https://pubmed.ncbi.nlm.nih.gov/16377242 DMY71LJ DI DMY71LJ DMY71LJ DN LY53857 DMY71LJ MI TTJQOD7 DMY71LJ MN 5-HT 2A receptor (HTR2A) DMY71LJ MT DTT DMY71LJ MA Antagonist DMY71LJ RN The 5-hydroxytryptamine2A receptor is involved in (+)-norfenfluramine-induced arterial contraction and blood pressure increase in deoxycorticostero... J Pharmacol Exp Ther. 2007 May;321(2):485-91. DMY71LJ RU https://pubmed.ncbi.nlm.nih.gov/17289838 DMY71LJ DI DMY71LJ DMY71LJ DN LY53857 DMY71LJ MI TT0K1SC DMY71LJ MN 5-HT 2B receptor (HTR2B) DMY71LJ MT DTT DMY71LJ MA Antagonist DMY71LJ RN p-Chloroamphetamine, a serotonin-releasing drug, elicited in rats a hyperglycemia mediated by the 5-HT1A and 5-HT2B/2C receptors. Eur J Pharmacol. 1998 Oct 23;359(2-3):185-90. DMY71LJ RU https://pubmed.ncbi.nlm.nih.gov/9832390 DMY71LJ DI DMY71LJ DMY71LJ DN LY53857 DMY71LJ MI TTWJBZ5 DMY71LJ MN 5-HT 2C receptor (HTR2C) DMY71LJ MT DTT DMY71LJ MA Antagonist DMY71LJ RN The 5-hydroxytryptamine2A receptor is involved in (+)-norfenfluramine-induced arterial contraction and blood pressure increase in deoxycorticostero... J Pharmacol Exp Ther. 2007 May;321(2):485-91. DMY71LJ RU https://pubmed.ncbi.nlm.nih.gov/17289838 DM679IY DI DM679IY DM679IY DN LZ-8 DM679IY MI TTISGCA DM679IY MN Toll-like receptor 4 (TLR4) DM679IY MT DTT DM679IY MA Modulator DM679IY RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1754). DM679IY RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1754 DMUIGM3 DI DMUIGM3 DMUIGM3 DN M-216765 DMUIGM3 MI TTSLI08 DMUIGM3 MN Adenosine receptor (ADOR) DMUIGM3 MT DTT DMUIGM3 MA Modulator DMUIGM3 RN US patent application no. 2010,0009,934, Beta adrenergic receptor agonists for the treatment of b-cell proliferative disorders. DMUIGM3 RU http://www.google.com/patents/US20100009934 DMIY51U DI DMIY51U DMIY51U DN M-241247 DMIY51U MI TTZ8EM9 DMIY51U MN Glycine receptor (GlyR) DMIY51U MT DTT DMIY51U MA Antagonist DMIY51U RN Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800003415) DMIY51U RU http://adisinsight.springer.com/drugs/800003415 DMIY51U DI DMIY51U DMIY51U DN M-241247 DMIY51U MI TT9IK2Z DMIY51U MN N-methyl-D-aspartate receptor (NMDAR) DMIY51U MT DTT DMIY51U MA Antagonist DMIY51U RN Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800003415) DMIY51U RU http://adisinsight.springer.com/drugs/800003415 DMBFCHW DI DMBFCHW DMBFCHW DN M-40401 DMBFCHW MI TT6RVLG DMBFCHW MN Superoxide dismutase Cu-Zn (SOD Cu-Zn) DMBFCHW MT DTT DMBFCHW MA Modulator DMBFCHW RN Protective effects of a new stable, highly active SOD mimetic, M40401 in splanchnic artery occlusion and reperfusion. Br J Pharmacol. 2001 Jan;132(1):19-29. DMBFCHW RU https://pubmed.ncbi.nlm.nih.gov/11156557 DM1SWOY DI DM1SWOY DM1SWOY DN MANUMYCIN A DM1SWOY MI TT7WZIJ DM1SWOY MN CAAX farnesyltransferase beta (FNTB) DM1SWOY MT DTT DM1SWOY MA Inhibitor DM1SWOY RN A novel metal-chelating inhibitor of protein farnesyltransferase. Bioorg Med Chem Lett. 2003 May 5;13(9):1523-6. DM1SWOY RU https://pubmed.ncbi.nlm.nih.gov/12699746 DM1SWOY DI DM1SWOY DM1SWOY DN MANUMYCIN A DM1SWOY MI TTXQKM3 DM1SWOY MN Farnesyl protein transferase (Ftase) DM1SWOY MT DTT DM1SWOY MA Inhibitor DM1SWOY RN A novel metal-chelating inhibitor of protein farnesyltransferase. Bioorg Med Chem Lett. 2003 May 5;13(9):1523-6. DM1SWOY RU https://pubmed.ncbi.nlm.nih.gov/12699746 DM31WQC DI DM31WQC DM31WQC DN Maxy-10 DM31WQC MI TT4TZ8J DM31WQC MN Interferon-beta (IFNB1) DM31WQC MT DTT DM31WQC MA Modulator DM31WQC RN US patent application no. 8,669,257, Phenazine derivatives and uses thereof as potassium channel modulators. DM31WQC RU https://www.google.com/patents/US8669257 DMXLCB6 DI DMXLCB6 DMXLCB6 DN MCI-826 DMXLCB6 MI TTGKOY9 DMXLCB6 MN Leukotriene CysLT1 receptor (CYSLTR1) DMXLCB6 MT DTT DMXLCB6 MA Antagonist DMXLCB6 RN Leukotriene receptors in the skin of rats differ from those of mouse skin or rat stomach strip. Eur J Pharmacol. 1992 Oct 20;221(2-3):333-42. DMXLCB6 RU https://pubmed.ncbi.nlm.nih.gov/1330627 DMRSOBG DI DMRSOBG DMRSOBG DN Mdl 101,146 DMRSOBG MI TTPLTSQ DMRSOBG MN Neutrophil elastase (NE) DMRSOBG MT DTT DMRSOBG MA Inhibitor DMRSOBG RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMRSOBG RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMRSOBG DI DMRSOBG DMRSOBG DN Mdl 101,146 DMRSOBG MI TT3NKIB DMRSOBG MN Pancreatic elastase 1 (CELA1) DMRSOBG MT DTT DMRSOBG MA Inhibitor DMRSOBG RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMRSOBG RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMHUJCI DI DMHUJCI DMHUJCI DN MDL-105519 DMHUJCI MI TTLD29N DMHUJCI MN Glutamate receptor ionotropic NMDA 1 (NMDAR1) DMHUJCI MT DTT DMHUJCI MA Inhibitor DMHUJCI RN CoMFA, synthesis, and pharmacological evaluation of (E)-3-(2-carboxy-2-arylvinyl)-4,6-dichloro-1H-indole-2-carboxylic acids: 3-[2-(3-aminophenyl)-2... J Med Chem. 2005 Feb 24;48(4):995-1018. DMHUJCI RU https://pubmed.ncbi.nlm.nih.gov/15715469 DMHUJCI DI DMHUJCI DMHUJCI DN MDL-105519 DMHUJCI MI TTKJEMQ DMHUJCI MN Glutamate receptor ionotropic NMDA 2A (NMDAR2A) DMHUJCI MT DTT DMHUJCI MA Inhibitor DMHUJCI RN CoMFA, synthesis, and pharmacological evaluation of (E)-3-(2-carboxy-2-arylvinyl)-4,6-dichloro-1H-indole-2-carboxylic acids: 3-[2-(3-aminophenyl)-2... J Med Chem. 2005 Feb 24;48(4):995-1018. DMHUJCI RU https://pubmed.ncbi.nlm.nih.gov/15715469 DMHUJCI DI DMHUJCI DMHUJCI DN MDL-105519 DMHUJCI MI TTN9D8E DMHUJCI MN Glutamate receptor ionotropic NMDA 2B (NMDAR2B) DMHUJCI MT DTT DMHUJCI MA Inhibitor DMHUJCI RN CoMFA, synthesis, and pharmacological evaluation of (E)-3-(2-carboxy-2-arylvinyl)-4,6-dichloro-1H-indole-2-carboxylic acids: 3-[2-(3-aminophenyl)-2... J Med Chem. 2005 Feb 24;48(4):995-1018. DMHUJCI RU https://pubmed.ncbi.nlm.nih.gov/15715469 DMMG1K3 DI DMMG1K3 DMMG1K3 DN MDL-201112 DMMG1K3 MI TTF8CQI DMMG1K3 MN Tumor necrosis factor (TNF) DMMG1K3 MT DTT DMMG1K3 MA Inhibitor DMMG1K3 RN Effect of the carbocyclic nucleoside analogue MDL 201,112 on inhibition of interferon-gamma-induced priming of Lewis (LEW/N) rat macrophages for enhanced respiratory burst and MHC class II Ia+ antigen expression. J Leukoc Biol. 1994 Aug;56(2):133-44. DMMG1K3 RU https://pubmed.ncbi.nlm.nih.gov/8071590 DM6X4IT DI DM6X4IT DM6X4IT DN MDL-28133A DM6X4IT MI TTYSN63 DM6X4IT MN 5-HT 2 receptor (5HT2R) DM6X4IT MT DTT DM6X4IT MA Modulator DM6X4IT RN Effects of MDL 28,133A, a 5-HT2 receptor antagonist, on platelet aggregation and coronary thrombosis in dogs. J Cardiovasc Pharmacol. 1994 Nov;24(5):761-72. DM6X4IT RU https://pubmed.ncbi.nlm.nih.gov/7532754 DM8ZDU2 DI DM8ZDU2 DM8ZDU2 DN MDL-28161 DM8ZDU2 MI TTJQOD7 DM8ZDU2 MN 5-HT 2A receptor (HTR2A) DM8ZDU2 MT DTT DM8ZDU2 MA Inhibitor DM8ZDU2 RN Ketanserin analogues: structure-affinity relationships for 5-HT2 and 5-HT1C serotonin receptor binding. J Med Chem. 1992 Dec 25;35(26):4903-10. DM8ZDU2 RU https://pubmed.ncbi.nlm.nih.gov/1479590 DMYK31O DI DMYK31O DMYK31O DN MDL-28170 DMYK31O MI TTG5QB7 DMYK31O MN Calpain-2 (CAPN2) DMYK31O MT DTT DMYK31O MA Inhibitor DMYK31O RN Synthesis of a small library of diketopiperazines as potential inhibitors of calpain. Bioorg Med Chem Lett. 2005 Jun 15;15(12):3034-8. DMYK31O RU https://pubmed.ncbi.nlm.nih.gov/15896956 DMBIDQX DI DMBIDQX DMBIDQX DN MDL-43291 DMBIDQX MI TTGKOY9 DMBIDQX MN Leukotriene CysLT1 receptor (CYSLTR1) DMBIDQX MT DTT DMBIDQX MA Modulator DMBIDQX RN Conformationally restricted leukotriene receptor antagonists: [(octahydro-2-oxo-7-tetradecylidene-2H-1-benzopyran-8-yl)thio]ace tic acids. Pharmacology. 1990;40(5):271-6. DMBIDQX RU https://www.ncbi.nlm.nih.gov/pubmed/2177202 DMBIDQX DI DMBIDQX DMBIDQX DN MDL-43291 DMBIDQX MI TT0PZR5 DMBIDQX MN Leukotriene CysLT2 receptor (CYSLTR2) DMBIDQX MT DTT DMBIDQX MA Modulator DMBIDQX RN Conformationally restricted leukotriene receptor antagonists: [(octahydro-2-oxo-7-tetradecylidene-2H-1-benzopyran-8-yl)thio]ace tic acids. Pharmacology. 1990;40(5):271-6. DMBIDQX RU https://www.ncbi.nlm.nih.gov/pubmed/2177202 DMHX6IC DI DMHX6IC DMHX6IC DN ME-3221 DMHX6IC MI TTGN1ZA DMHX6IC MN Angiotensin II receptor (AGTR) DMHX6IC MT DTT DMHX6IC MA Modulator DMHX6IC RN Protective effects of ME3221 on hypertensive complications and lifespan in salt-loaded stroke-prone spontaneously hypertensive rats. Clin Exp Pharmacol Physiol. 1996 Mar;23(3):229-35. DMHX6IC RU https://pubmed.ncbi.nlm.nih.gov/8934613 DMT3B4G DI DMT3B4G DMT3B4G DN MEDI-500 DMT3B4G MI TTBMAOZ DMT3B4G MN Regulatory protein unspecific (RGP) DMT3B4G MT DTT DMT3B4G MA Modulator DMT3B4G RN T10B9 (MEDI-500) mediated immunosuppression: studies on the mechanism of action. Clin Transplant. 1996 Dec;10(6 Pt 2):607-13. DMT3B4G RU https://pubmed.ncbi.nlm.nih.gov/8996751 DM4G0D5 DI DM4G0D5 DM4G0D5 DN MEDI-542 DM4G0D5 MI TTG84D3 DM4G0D5 MN Ephrin type-A receptor 4 (EPHA4) DM4G0D5 MT DTT DM4G0D5 RN Product Pipeline Review of MedImmune, LLC in 2012. DM4G0D5 RU http://www.researchandmarkets.com/reports/2245301/medimmune_llc_product_pipeline_review_2012.pdf DM185DR DI DM185DR DM185DR DN MEN-10207 DM185DR MI TTYO0A3 DM185DR MN Substance-K receptor (TACR2) DM185DR MT DTT DM185DR MA Modulator DM185DR RN Role of D-tryptophan for affinity of MEN 10207 tachykinin antagonist at NK2 receptors. Peptides. 1991 Sep-Oct;12(5):1015-8. DM185DR RU https://pubmed.ncbi.nlm.nih.gov/1666180 DM35ABD DI DM35ABD DM35ABD DN MEN-10627 DM35ABD MI TTYO0A3 DM35ABD MN Substance-K receptor (TACR2) DM35ABD MT DTT DM35ABD MA Modulator DM35ABD RN MEN 10,627, a novel polycyclic peptide antagonist of tachykinin NK2 receptors. J Pharmacol Exp Ther. 1994 Dec;271(3):1489-500. DM35ABD RU https://pubmed.ncbi.nlm.nih.gov/7996462 DM57S3D DI DM57S3D DM57S3D DN MEN-10690 DM57S3D MI TT84ETX DM57S3D MN Human immunodeficiency virus Reverse transcriptase (HIV RT) DM57S3D MT DTT DM57S3D MA Modulator DM57S3D RN US patent application no. 2004,0023,290, Novel therapeutic agents that modulate enzymatic processes. DM57S3D RU http://www.google.com/patents/US20040023290 DMKS1W0 DI DMKS1W0 DMKS1W0 DN MEN-10880 DMKS1W0 MI TT84ETX DMKS1W0 MN Human immunodeficiency virus Reverse transcriptase (HIV RT) DMKS1W0 MT DTT DMKS1W0 MA Modulator DMKS1W0 RN US patent application no. 2004,0023,290, Novel therapeutic agents that modulate enzymatic processes. DMKS1W0 RU http://www.google.com/patents/US20040023290 DM6UYN1 DI DM6UYN1 DM6UYN1 DN MEN-10979 DM6UYN1 MI TT84ETX DM6UYN1 MN Human immunodeficiency virus Reverse transcriptase (HIV RT) DM6UYN1 MT DTT DM6UYN1 MA Modulator DM6UYN1 RN New arylpyrido-diazepine and -thiodiazepine derivatives are potent and highly selective HIV-1 inhibitors targeted at the reverse transcriptase. Antiviral Res. 1996 May;30(2-3):109-24. DM6UYN1 RU https://pubmed.ncbi.nlm.nih.gov/8783803 DMEYNB0 DI DMEYNB0 DMEYNB0 DN MEN-11149 DMEYNB0 MI TTZPO1L DMEYNB0 MN Substance-P receptor (TACR1) DMEYNB0 MT DTT DMEYNB0 MA Antagonist DMEYNB0 RN Pharmacology of the peptidomimetic, MEN 11149, a new potent, selective and orally effective tachykinin NK1 receptor antagonist. Eur J Pharmacol. 1998 Jan 12;341(2-3):201-9. DMEYNB0 RU https://pubmed.ncbi.nlm.nih.gov/9543241 DMNTIWC DI DMNTIWC DMNTIWC DN MEN-11467 DMNTIWC MI TTZPO1L DMNTIWC MN Substance-P receptor (TACR1) DMNTIWC MT DTT DMNTIWC MA Antagonist DMNTIWC RN Effect of the long-acting tachykinin NK(1) receptor antagonist MEN 11467 on tracheal mucus secretion in allergic ferrets. Br J Pharmacol. 2001 Jan;132(1):189-96. DMNTIWC RU https://pubmed.ncbi.nlm.nih.gov/11156577 DMC8J6F DI DMC8J6F DMC8J6F DN Methylthioadenosine DMC8J6F MI TTK25J1 DMC8J6F MN Adenosine A1 receptor (ADORA1) DMC8J6F MT DTT DMC8J6F MA Inhibitor DMC8J6F RN Novel amino acid derived natural products from the ascidian Atriolum robustum: identification and pharmacological characterization of a unique aden... J Med Chem. 2004 Apr 22;47(9):2243-55. DMC8J6F RU https://pubmed.ncbi.nlm.nih.gov/15084123 DMC8J6F DI DMC8J6F DMC8J6F DN Methylthioadenosine DMC8J6F MI TTM2AOE DMC8J6F MN Adenosine A2a receptor (ADORA2A) DMC8J6F MT DTT DMC8J6F MA Inhibitor DMC8J6F RN Novel amino acid derived natural products from the ascidian Atriolum robustum: identification and pharmacological characterization of a unique aden... J Med Chem. 2004 Apr 22;47(9):2243-55. DMC8J6F RU https://pubmed.ncbi.nlm.nih.gov/15084123 DMC8J6F DI DMC8J6F DMC8J6F DN Methylthioadenosine DMC8J6F MI TTNE7KG DMC8J6F MN Adenosine A2b receptor (ADORA2B) DMC8J6F MT DTT DMC8J6F MA Inhibitor DMC8J6F RN Novel amino acid derived natural products from the ascidian Atriolum robustum: identification and pharmacological characterization of a unique aden... J Med Chem. 2004 Apr 22;47(9):2243-55. DMC8J6F RU https://pubmed.ncbi.nlm.nih.gov/15084123 DMC8J6F DI DMC8J6F DMC8J6F DN Methylthioadenosine DMC8J6F MI TTJFY5U DMC8J6F MN Adenosine A3 receptor (ADORA3) DMC8J6F MT DTT DMC8J6F MA Inhibitor DMC8J6F RN Novel amino acid derived natural products from the ascidian Atriolum robustum: identification and pharmacological characterization of a unique aden... J Med Chem. 2004 Apr 22;47(9):2243-55. DMC8J6F RU https://pubmed.ncbi.nlm.nih.gov/15084123 DMC8J6F DI DMC8J6F DMC8J6F DN Methylthioadenosine DMC8J6F MI DE1DR6Y DMC8J6F MN S-adenosylhomocysteine nucleosidase (mtnN) DMC8J6F MT DME DMC8J6F MA Metabolism DMC8J6F RN Selective killing of Klebsiella pneumoniae by 5-trifluoromethylthioribose. Chemotherapeutic exploitation of the enzyme 5-methylthioribose kinase. J Biol Chem. 1990 Jan 15;265(2):831-7. DMC8J6F RU https://pubmed.ncbi.nlm.nih.gov/2153115 DMC8J6F DI DMC8J6F DMC8J6F DN Methylthioadenosine DMC8J6F MI TTDBX7N DMC8J6F MN S-methyl-5'-thioadenosine phosphorylase (MTAP) DMC8J6F MT DTT DMC8J6F MA Inhibitor DMC8J6F RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMC8J6F RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMC8J6F DI DMC8J6F DMC8J6F DN Methylthioadenosine DMC8J6F MI DEXHBCR DMC8J6F MN S-methyl-5'-thioadenosine phosphorylase (MTAP) DMC8J6F MT DME DMC8J6F MA Metabolism DMC8J6F RN Picomolar transition state analogue inhibitors of human 5'-methylthioadenosine phosphorylase and X-ray structure with MT-immucillin-A. Biochemistry. 2004 Jan 13;43(1):9-18. DMC8J6F RU https://www.ncbi.nlm.nih.gov/pubmed/?term=14705926 DMS5CZ4 DI DMS5CZ4 DMS5CZ4 DN METRIFUDIL DMS5CZ4 MI TTK25J1 DMS5CZ4 MN Adenosine A1 receptor (ADORA1) DMS5CZ4 MT DTT DMS5CZ4 MA Inhibitor DMS5CZ4 RN N-substituted adenosines as novel neuroprotective A(1) agonists with diminished hypotensive effects. J Med Chem. 1999 Sep 9;42(18):3463-77. DMS5CZ4 RU https://pubmed.ncbi.nlm.nih.gov/10479279 DMS5CZ4 DI DMS5CZ4 DMS5CZ4 DN METRIFUDIL DMS5CZ4 MI TTM2AOE DMS5CZ4 MN Adenosine A2a receptor (ADORA2A) DMS5CZ4 MT DTT DMS5CZ4 MA Inhibitor DMS5CZ4 RN N-substituted adenosines as novel neuroprotective A(1) agonists with diminished hypotensive effects. J Med Chem. 1999 Sep 9;42(18):3463-77. DMS5CZ4 RU https://pubmed.ncbi.nlm.nih.gov/10479279 DMS5CZ4 DI DMS5CZ4 DMS5CZ4 DN METRIFUDIL DMS5CZ4 MI TTJFY5U DMS5CZ4 MN Adenosine A3 receptor (ADORA3) DMS5CZ4 MT DTT DMS5CZ4 MA Inhibitor DMS5CZ4 RN (N)-methanocarba 2,N6-disubstituted adenine nucleosides as highly potent and selective A3 adenosine receptor agonists. J Med Chem. 2005 Mar 24;48(6):1745-58. DMS5CZ4 RU https://pubmed.ncbi.nlm.nih.gov/15771421 DM1LGKP DI DM1LGKP DM1LGKP DN Mevastatin DM1LGKP MI DECV2ME DM1LGKP MN Cytochrome P450 105D7 (cyp105) DM1LGKP MT DME DM1LGKP MA Metabolism DM1LGKP RN The metagenome of Caracolus marginella gut microbiome using culture independent approaches and shotgun sequencing. Data Brief. 2017 Nov 22;16:501-505. DM1LGKP RU https://pubmed.ncbi.nlm.nih.gov/29270447 DM1LGKP DI DM1LGKP DM1LGKP DN Mevastatin DM1LGKP MI TTPADOQ DM1LGKP MN HMG-CoA reductase (HMGCR) DM1LGKP MT DTT DM1LGKP MA Antagonist DM1LGKP RN Regulation of CYP2B6 and CYP3A expression by hydroxymethylglutaryl coenzyme A inhibitors in primary cultured human hepatocytes. Drug Metab Dispos. 2002 Dec;30(12):1400-5. DM1LGKP RU https://pubmed.ncbi.nlm.nih.gov/12433810 DMHV5OD DI DMHV5OD DMHV5OD DN MF268 DMHV5OD MI TT1RS9F DMHV5OD MN Acetylcholinesterase (AChE) DMHV5OD MT DTT DMHV5OD MA Inhibitor DMHV5OD RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DMHV5OD RU https://pubmed.ncbi.nlm.nih.gov/10592235 DM72MQP DI DM72MQP DM72MQP DN MF-5137 DM72MQP MI TTN6J5F DM72MQP MN Bacterial DNA gyrase (Bact gyrase) DM72MQP MT DTT DM72MQP MA Modulator DM72MQP RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. DM72MQP RU https://www.fda.gov/ DM47WS2 DI DM47WS2 DM47WS2 DN MF-8615 DM47WS2 MI TT1RS9F DM47WS2 MN Acetylcholinesterase (AChE) DM47WS2 MT DTT DM47WS2 MA Inhibitor DM47WS2 RN Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800006922) DM47WS2 RU http://adisinsight.springer.com/drugs/800006922 DM9GOT6 DI DM9GOT6 DM9GOT6 DN MGBG DM9GOT6 MI TTBFROQ DM9GOT6 MN S-adenosylmethionine decarboxylase proenzyme (AMD1) DM9GOT6 MT DTT DM9GOT6 MA Inhibitor DM9GOT6 RN A phase I study of a new polyamine biosynthesis inhibitor, SAM486A, in cancer patients with solid tumours. Br J Cancer. 2000 Sep;83(5):594-601. DM9GOT6 RU https://pubmed.ncbi.nlm.nih.gov/10944598 DM96WKA DI DM96WKA DM96WKA DN Midaglizole DM96WKA MI TT2NUT5 DM96WKA MN Adrenergic receptor alpha-2C (ADRA2C) DM96WKA MT DTT DM96WKA MA Modulator DM96WKA RN Studies of midaglizole (DG-5128). A new type of oral hypoglycemic drug in healthy subjects. Diabetes. 1987 Feb;36(2):216-20. DM96WKA RU https://pubmed.ncbi.nlm.nih.gov/3542646 DMJTR0U DI DMJTR0U DMJTR0U DN Milacemide DMJTR0U MI TTGP7BY DMJTR0U MN Monoamine oxidase type B (MAO-B) DMJTR0U MT DTT DMJTR0U MA Modulator DMJTR0U RN Milacemide, the selective substrate and enzyme-activated specific inhibitor of monoamine oxidase B, increases dopamine but not serotonin in caudate nucleus of rhesus monkey. Neurochem Int. 1990;17(2):325-9. DMJTR0U RU https://pubmed.ncbi.nlm.nih.gov/20504633 DMZNWAV DI DMZNWAV DMZNWAV DN Miltirone DMZNWAV MI TTPTXIN DMZNWAV MN Translocator protein (TSPO) DMZNWAV MT DTT DMZNWAV MA Modulator DMZNWAV RN Miltirone, a central benzodiazepine receptor partial agonist from a Chinese medicinal herb Salvia miltiorrhiza. Neurosci Lett. 1991 Jun 24;127(2):237-41. DMZNWAV RU https://pubmed.ncbi.nlm.nih.gov/1652718 DMQB8TW DI DMQB8TW DMQB8TW DN Mimosine DMQB8TW MI TTO8YH2 DMQB8TW MN Plasmodium Serine hydroxymethyltransferase (Malaria SHMT) DMQB8TW MT DTT DMQB8TW MA Inhibitor DMQB8TW RN Mimosine targets serine hydroxymethyltransferase. J Biol Chem. 1996 Feb 2;271(5):2548-56. DMQB8TW RU https://pubmed.ncbi.nlm.nih.gov/8576220 DM7IXH3 DI DM7IXH3 DM7IXH3 DN MINAMESTANE DM7IXH3 MI TTSZLWK DM7IXH3 MN Aromatase (CYP19A1) DM7IXH3 MT DTT DM7IXH3 MA Inhibitor DM7IXH3 RN High-performance liquid chromatographic determination of FCE 24928, a new aromatase inhibitor, in human plasma. J Chromatogr A. 1994 Feb 4;660(1-2):293-8. DM7IXH3 RU https://pubmed.ncbi.nlm.nih.gov/8148992 DMO06JV DI DMO06JV DMO06JV DN Mitoflaxone DMO06JV MI TT3SZBT DMO06JV MN von Willebrand factor (VWF) DMO06JV MT DTT DMO06JV MA Inhibitor DMO06JV RN Novel approaches to the treatment of thrombosis. Trends Pharmacol Sci. 2002 Jan;23(1):25-32. DMO06JV RU https://pubmed.ncbi.nlm.nih.gov/11804648 DMT9QB5 DI DMT9QB5 DMT9QB5 DN MIV-170 DMT9QB5 MI TT84ETX DMT9QB5 MN Human immunodeficiency virus Reverse transcriptase (HIV RT) DMT9QB5 MT DTT DMT9QB5 MA Inhibitor DMT9QB5 RN Inhibition of HIV-1 by non-nucleoside reverse transcriptase inhibitors via an induced fit mechanism-Importance of slow dissociation and relaxation rates for antiviral efficacy. Biochem Pharmacol. 2010 Oct 15;80(8):1133-40. DMT9QB5 RU https://pubmed.ncbi.nlm.nih.gov/20599774 DMAITRL DI DMAITRL DMAITRL DN MKC-1313 DMAITRL MI TTBH0VX DMAITRL MN Histone deacetylase (HDAC) DMAITRL MT DTT DMAITRL MA Inhibitor DMAITRL RN ENTREMED TO ACQUIRE MIIKANA THERAPEUTICS. U.S. Securities and Exchange Commission. December 22, 2005. DMAITRL RU http://www.sec.gov/Archives/edgar/data/895051/000095013305005669/w15948exv99w1.htm DMF27BS DI DMF27BS DMF27BS DN MMV00/0053 DMF27BS MI TTVTX4N DMF27BS MN Bacterial Fatty acid synthetase I (Bact inhA) DMF27BS MT DTT DMF27BS MA Inhibitor DMF27BS RN SAR and pharmacophore models for the rhodanine inhibitors of Plasmodium falciparum enoyl-acyl carrier protein reductase. IUBMB Life. 2010 Mar;62(3):204-13. DMF27BS RU https://pubmed.ncbi.nlm.nih.gov/20131353 DM543VY DI DM543VY DM543VY DN MOL-218 DM543VY MI TTSXVID DM543VY MN Nuclear factor NF-kappa-B (NFKB) DM543VY MT DTT DM543VY MA Inhibitor DM543VY RN NF-kappaB plays a major role during the systemic and local acute inflammatory response following intestinal reperfusion injury. Br J Pharmacol. 2005 May;145(2):246-54. DM543VY RU https://pubmed.ncbi.nlm.nih.gov/15765103 DMRCH1M DI DMRCH1M DMRCH1M DN MOR-102 DMRCH1M MI TTCT6F7 DMRCH1M MN Intercellular adhesion molecule ICAM-1 (ICAM1) DMRCH1M MT DTT DMRCH1M RN Efficacy of the fully human monoclonal antibody MOR102 (#5) against intercellular adhesion molecule 1 in the psoriasis-severe combined immunodeficient mouse model. Br J Dermatol. 2005 Oct;153(4):758-66. DMRCH1M RU https://pubmed.ncbi.nlm.nih.gov/16181457 DMO2S6T DI DMO2S6T DMO2S6T DN MOXIFETIN HYDROGEN MALEATE DMO2S6T MI TT3ROYC DMO2S6T MN Serotonin transporter (SERT) DMO2S6T MT DTT DMO2S6T RN Moxidectin causes adult worm mortality of human lymphatic filarial parasite Brugia malayi in rodent models. Folia Parasitol (Praha). 2014 Dec;61(6):561-70. DMO2S6T RU https://pubmed.ncbi.nlm.nih.gov/25651699 DMAVD4Q DI DMAVD4Q DMAVD4Q DN MPI-461359 DMAVD4Q MI TTFGZB6 DMAVD4Q MN Human immunodeficiency virus GAG protein (HIV gag) DMAVD4Q MT DTT DMAVD4Q MA Inhibitor DMAVD4Q RN Human Immunodeficiency Virus Gag and protease: partners in resistance. Retrovirology. 2012 Aug 6;9:63. DMAVD4Q RU https://pubmed.ncbi.nlm.nih.gov/22867298 DM4A92X DI DM4A92X DM4A92X DN MRL-953 DM4A92X MI TT51DEV DM4A92X MN Interleukin 1 receptor type 2 (IL1R2) DM4A92X MT DTT DM4A92X MA Agonist DM4A92X RN SDZ MRL 953, a lipid A analog as selective cytokine inducer. Prog Clin Biol Res. 1995;392:549-65. DM4A92X RU https://pubmed.ncbi.nlm.nih.gov/8524963 DMXERCA DI DMXERCA DMXERCA DN MS-377 DMXERCA MI TT5TPI6 DMXERCA MN Opioid receptor sigma 1 (OPRS1) DMXERCA MT DTT DMXERCA MA Antagonist DMXERCA RN The pipeline and future of drug development in schizophrenia. Mol Psychiatry. 2007 Oct;12(10):904-22. DMXERCA RU https://pubmed.ncbi.nlm.nih.gov/17667958 DMNYLEU DI DMNYLEU DMNYLEU DN MSC-204 DMNYLEU MI TT84ETX DMNYLEU MN Human immunodeficiency virus Reverse transcriptase (HIV RT) DMNYLEU MT DTT DMNYLEU MA Modulator DMNYLEU RN WO patent application no. 2004,0290,42, Pyrazole derivatives as reverse transcriptase inhibitors. DMNYLEU RU http://www.google.com/patents/WO2004029042A1?cl=en DMXW67H DI DMXW67H DMXW67H DN MX-6120 DMXW67H MI TTKRD0G DMXW67H MN Endothelin A receptor (EDNRA) DMXW67H MT DTT DMXW67H MA Antagonist DMXW67H RN Endothelin receptor antagonists in heart failure: current status and future directions. Drugs. 2004;64(10):1029-40. DMXW67H RU https://pubmed.ncbi.nlm.nih.gov/15139784 DMP26BW DI DMP26BW DMP26BW DN MX-7065 DMP26BW MI TTLZS4Q DMP26BW MN M-phase inducer phosphatase 1 (MPIP1) DMP26BW MT DTT DMP26BW MA Inhibitor DMP26BW RN Handbook of Assay Development in Drug Discovery, Lisa K. Minor, 2013. Page(11). DMP26BW RU https://books.google.com.hk/books?id=RmrLBQAAQBAJ&pg=PA11&lpg=PA11&dq=%22MX-7214%22+++Cdc25&source=bl&ots=un9o85IdEu&sig=UeS1s5P6-6iLhA8n-4L8xMrnpuo&hl=zh-CN&sa=X&ved=0CBoQ6AEwAGoVChMIxIXHkOHFyAIVRASOCh2thghY#v=onepage&q=%22MX-7214%22%20%20%20Cdc25&f=false DMP26BW DI DMP26BW DMP26BW DN MX-7065 DMP26BW MI TTR0SWN DMP26BW MN M-phase inducer phosphatase 2 (MPIP2) DMP26BW MT DTT DMP26BW MA Inhibitor DMP26BW RN Handbook of Assay Development in Drug Discovery, Lisa K. Minor, 2013. Page(11). DMP26BW RU https://books.google.com.hk/books?id=RmrLBQAAQBAJ&pg=PA11&lpg=PA11&dq=%22MX-7214%22+++Cdc25&source=bl&ots=un9o85IdEu&sig=UeS1s5P6-6iLhA8n-4L8xMrnpuo&hl=zh-CN&sa=X&ved=0CBoQ6AEwAGoVChMIxIXHkOHFyAIVRASOCh2thghY#v=onepage&q=%22MX-7214%22%20%20%20Cdc25&f=false DMP26BW DI DMP26BW DMP26BW DN MX-7065 DMP26BW MI TTESBNC DMP26BW MN M-phase inducer phosphatase 3 (MPIP3) DMP26BW MT DTT DMP26BW MA Inhibitor DMP26BW RN Handbook of Assay Development in Drug Discovery, Lisa K. Minor, 2013. Page(11). DMP26BW RU https://books.google.com.hk/books?id=RmrLBQAAQBAJ&pg=PA11&lpg=PA11&dq=%22MX-7214%22+++Cdc25&source=bl&ots=un9o85IdEu&sig=UeS1s5P6-6iLhA8n-4L8xMrnpuo&hl=zh-CN&sa=X&ved=0CBoQ6AEwAGoVChMIxIXHkOHFyAIVRASOCh2thghY#v=onepage&q=%22MX-7214%22%20%20%20Cdc25&f=false DMNZ356 DI DMNZ356 DMNZ356 DN MX-781 DMNZ356 MI TTOD7B3 DMNZ356 MN Retinoic acid receptor (RAR) DMNZ356 MT DTT DMNZ356 MA Modulator DMNZ356 RN The retinoid antagonist MX781 induces clusterin expression in prostate cancer cells via heat shock factor-1 and activator protein-1 transcription factors. Cancer Res. 2004 Aug 15;64(16):5905-12. DMNZ356 RU https://pubmed.ncbi.nlm.nih.gov/15313936 DM31CV2 DI DM31CV2 DM31CV2 DN NAFAZATROM DM31CV2 MI TT2J34L DM31CV2 MN Arachidonate 5-lipoxygenase (5-LOX) DM31CV2 MT DTT DM31CV2 MA Inhibitor DM31CV2 RN Design, synthesis, and 5-lipoxygenase-inhibiting properties of 1-thio-substituted butadienes. J Med Chem. 1990 Apr;33(4):1163-70. DM31CV2 RU https://pubmed.ncbi.nlm.nih.gov/2319562 DM7T2FO DI DM7T2FO DM7T2FO DN Naltiazem hydrochloride DM7T2FO MI TT5HONZ DM7T2FO MN Calcium channel unspecific (CaC) DM7T2FO MT DTT DM7T2FO MA Blocker DM7T2FO RN Assessment of hyperglycemia after calcium channel blocker overdoses involving diltiazem or verapamil. Crit Care Med. 2007 Sep;35(9):2071-5. DM7T2FO RU https://pubmed.ncbi.nlm.nih.gov/17855820 DMML3J4 DI DMML3J4 DMML3J4 DN NAN-190 DMML3J4 MI TTSQIFT DMML3J4 MN 5-HT 1A receptor (HTR1A) DMML3J4 MT DTT DMML3J4 MA Antagonist DMML3J4 RN Influence of 5-HT1A receptor antagonism on plus-maze behaviour in mice. II. WAY 100635, SDZ 216-525 and NAN-190. Pharmacol Biochem Behav. 1997 Oct;58(2):593-603. DMML3J4 RU https://pubmed.ncbi.nlm.nih.gov/9300624 DM8FB6E DI DM8FB6E DM8FB6E DN Navuridine DM8FB6E MI TT84ETX DM8FB6E MN Human immunodeficiency virus Reverse transcriptase (HIV RT) DM8FB6E MT DTT DM8FB6E MA Inhibitor DM8FB6E RN Synthesis and anti-human immunodeficiency virus (HIV-1) activity of 3'-deoxy-3'-(triazol-1-yl)thymidines and 2',3'-dideoxy-3'-(triazol-1-yl)uridines and inhibition of reverse transcriptase by their 5'-triphosphates. Chem Pharm Bull (Tokyo). 1990 Sep;38(9):2597-601. DM8FB6E RU https://pubmed.ncbi.nlm.nih.gov/1704819 DMJVTQN DI DMJVTQN DMJVTQN DN NB-598 DMJVTQN MI TTE14XG DMJVTQN MN Squalene monooxygenase (SQLE) DMJVTQN MT DTT DMJVTQN MA Inhibitor DMJVTQN RN Squalene epoxidase as hypocholesterolemic drug target revisited. Prog Lipid Res. 2003 Jan;42(1):37-50. DMJVTQN RU https://pubmed.ncbi.nlm.nih.gov/12467639 DM3JY2N DI DM3JY2N DM3JY2N DN NBI-37582 DM3JY2N MI TT7EFHR DM3JY2N MN Corticotropin-releasing factor receptor 1 (CRHR1) DM3JY2N MT DTT DM3JY2N MA Antagonist DM3JY2N RN CenterWatch. Drugs in Clinical Trials Database. CenterWatch. 2008. DM3JY2N RU http://www.centerwatch.com/ DMEH50J DI DMEH50J DMEH50J DN NE-033 DMEH50J MI TT5TPI6 DMEH50J MN Opioid receptor sigma 1 (OPRS1) DMEH50J MT DTT DMEH50J MA Modulator DMEH50J RN Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800004064) DMEH50J RU http://adisinsight.springer.com/drugs/800004064 DMP4J7T DI DMP4J7T DMP4J7T DN NE-100 DMP4J7T MI TT5TPI6 DMP4J7T MN Opioid receptor sigma 1 (OPRS1) DMP4J7T MT DTT DMP4J7T MA Antagonist DMP4J7T RN The pipeline and future of drug development in schizophrenia. Mol Psychiatry. 2007 Oct;12(10):904-22. DMP4J7T RU https://pubmed.ncbi.nlm.nih.gov/17667958 DMHYQ8K DI DMHYQ8K DMHYQ8K DN Nerve growth factor DMHYQ8K MI TTDN3LF DMHYQ8K MN Nerve growth factor (NGF) DMHYQ8K MT DTT DMHYQ8K MA Modulator DMHYQ8K RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. DMHYQ8K RU https://www.fda.gov/ DMFA26E DI DMFA26E DMFA26E DN NGD-93-1 DMFA26E MI TTEX248 DMFA26E MN Dopamine D2 receptor (D2R) DMFA26E MT DTT DMFA26E MA Modulator DMFA26E RN Dopamine D4 receptors in human postmortem brain tissue of normal and schizophrenic subjects. An [3]NGD-94-1 study. Schizophrenia Research Volume 29, Issues 1-2, January 1998, Pages 93. DMFA26E RU http://www.sciencedirect.com/science/article/pii/S0920996497885337 DMSPWMF DI DMSPWMF DMSPWMF DN Niguldipine DMSPWMF MI TTNGILX DMSPWMF MN Adrenergic receptor alpha-1A (ADRA1A) DMSPWMF MT DTT DMSPWMF MA Inhibitor DMSPWMF RN Alpha- and beta-adrenoceptors: from the gene to the clinic. 2. Structure-activity relationships and therapeutic applications. J Med Chem. 1995 Sep 15;38(19):3681-716. DMSPWMF RU https://pubmed.ncbi.nlm.nih.gov/7562902 DMSPWMF DI DMSPWMF DMSPWMF DN Niguldipine DMSPWMF MI TTBRKXS DMSPWMF MN Adrenergic receptor alpha-1B (ADRA1B) DMSPWMF MT DTT DMSPWMF MA Inhibitor DMSPWMF RN Alpha- and beta-adrenoceptors: from the gene to the clinic. 2. Structure-activity relationships and therapeutic applications. J Med Chem. 1995 Sep 15;38(19):3681-716. DMSPWMF RU https://pubmed.ncbi.nlm.nih.gov/7562902 DMSPWMF DI DMSPWMF DMSPWMF DN Niguldipine DMSPWMF MI TT34BHT DMSPWMF MN Adrenergic receptor alpha-1D (ADRA1D) DMSPWMF MT DTT DMSPWMF MA Inhibitor DMSPWMF RN Alpha- and beta-adrenoceptors: from the gene to the clinic. 2. Structure-activity relationships and therapeutic applications. J Med Chem. 1995 Sep 15;38(19):3681-716. DMSPWMF RU https://pubmed.ncbi.nlm.nih.gov/7562902 DMSPWMF DI DMSPWMF DMSPWMF DN Niguldipine DMSPWMF MI DE4LYSA DMSPWMF MN Cytochrome P450 3A4 (CYP3A4) DMSPWMF MT DME DMSPWMF MA Metabolism DMSPWMF RN Integrated analysis on the physicochemical properties of dihydropyridine calcium channel blockers in grapefruit juice interactions. Curr Pharm Biotechnol. 2012 Jul;13(9):1705-17. DMSPWMF RU https://www.ncbi.nlm.nih.gov/pubmed/?term=22039822 DMSPWMF DI DMSPWMF DMSPWMF DN Niguldipine DMSPWMF MI DTUGYRD DMSPWMF MN P-glycoprotein 1 (ABCB1) DMSPWMF MT DTP DMSPWMF MA Substrate DMSPWMF RN Human intestinal transporter database: QSAR modeling and virtual profiling of drug uptake, efflux and interactions. Pharm Res. 2013 Apr;30(4):996-1007. DMSPWMF RU https://doi.org/10.1007/s11095-012-0935-x DMSPWMF DI DMSPWMF DMSPWMF DN Niguldipine DMSPWMF MI TTZIFHC DMSPWMF MN Voltage-gated calcium channel alpha Cav1.2 (CACNA1C) DMSPWMF MT DTT DMSPWMF MA Inhibitor DMSPWMF RN Alpha- and beta-adrenoceptors: from the gene to the clinic. 2. Structure-activity relationships and therapeutic applications. J Med Chem. 1995 Sep 15;38(19):3681-716. DMSPWMF RU https://pubmed.ncbi.nlm.nih.gov/7562902 DM4U7XB DI DM4U7XB DM4U7XB DN NIK-616 DM4U7XB MI TTZ97H5 DM4U7XB MN Phosphodiesterase 4A (PDE4A) DM4U7XB MT DTT DM4U7XB MA Inhibitor DM4U7XB RN Preclinical trials in Chronic obstructive pulmonary disease in Japan (PO). 2004 DM4U7XB RU http://adisinsight.springer.com/drugs/800020194 DM4U7XB DI DM4U7XB DM4U7XB DN NIK-616 DM4U7XB MI TTVIAT9 DM4U7XB MN Phosphodiesterase 4B (PDE4B) DM4U7XB MT DTT DM4U7XB MA Inhibitor DM4U7XB RN Preclinical trials in Chronic obstructive pulmonary disease in Japan (PO). 2004 DM4U7XB RU http://adisinsight.springer.com/drugs/800020194 DM4U7XB DI DM4U7XB DM4U7XB DN NIK-616 DM4U7XB MI TTSKMI8 DM4U7XB MN Phosphodiesterase 4D (PDE4D) DM4U7XB MT DTT DM4U7XB MA Inhibitor DM4U7XB RN Preclinical trials in Chronic obstructive pulmonary disease in Japan (PO). 2004 DM4U7XB RU http://adisinsight.springer.com/drugs/800020194 DMR1NMD DI DMR1NMD DMR1NMD DN Nimesulide DMR1NMD MI DE4LYSA DMR1NMD MN Cytochrome P450 3A4 (CYP3A4) DMR1NMD MT DME DMR1NMD MA Metabolism DMR1NMD RN Integrated analysis on the physicochemical properties of dihydropyridine calcium channel blockers in grapefruit juice interactions. Curr Pharm Biotechnol. 2012 Jul;13(9):1705-17. DMR1NMD RU https://www.ncbi.nlm.nih.gov/pubmed/?term=22039822 DMR1NMD DI DMR1NMD DMR1NMD DN Nimesulide DMR1NMD MI TTSZDQU DMR1NMD MN Lactotransferrin (LTF) DMR1NMD MT DTT DMR1NMD MA Inhibitor DMR1NMD RN Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. DMR1NMD RU https://pubmed.ncbi.nlm.nih.gov/11752352 DMR1NMD DI DMR1NMD DMR1NMD DN Nimesulide DMR1NMD MI TTVKILB DMR1NMD MN Prostaglandin G/H synthase 2 (COX-2) DMR1NMD MT DTT DMR1NMD MA Inhibitor DMR1NMD RN Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. DMR1NMD RU https://pubmed.ncbi.nlm.nih.gov/11752352 DMR1NMD DI DMR1NMD DMR1NMD DN Nimesulide DMR1NMD MI TTA5MS9 DMR1NMD MN TNF related apoptosis inducing ligand (TNFSF10) DMR1NMD MT DTT DMR1NMD MA Modulator DMR1NMD RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. DMR1NMD RU https://www.fda.gov/ DM5IFU9 DI DM5IFU9 DM5IFU9 DN NMI-1182 DM5IFU9 MI TTK0943 DM5IFU9 MN Prostaglandin G/H synthase (COX) DM5IFU9 MT DTT DM5IFU9 MA Inhibitor DM5IFU9 RN NMI-1182, a gastro-protective cyclo-oxygenase-inhibiting nitric oxide donor. Inflammopharmacology. 2005;12(5-6):521-34. DM5IFU9 RU https://pubmed.ncbi.nlm.nih.gov/16259719 DMX6DNZ DI DMX6DNZ DMX6DNZ DN NMI-150 DMX6DNZ MI TTVKILB DMX6DNZ MN Prostaglandin G/H synthase 2 (COX-2) DMX6DNZ MT DTT DMX6DNZ MA Inhibitor DMX6DNZ RN Selective COX-2 Inhibitors: A Review of Their Structure-Activity Relationships. Iran J Pharm Res. 2011 Autumn; 10(4): 655-683. DMX6DNZ RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3813081/ DMPZ1EC DI DMPZ1EC DMPZ1EC DN NNC 05-2045 DMPZ1EC MI TTV9MQG DMPZ1EC MN Gamma-aminobutyric acid uptake (GABAU) DMPZ1EC MT DTT DMPZ1EC MA Inhibitor DMPZ1EC RN GABA-level increasing and anticonvulsant effects of three different GABA uptake inhibitors. Neuropharmacology. 2000 Sep;39(12):2399-407. DMPZ1EC RU https://pubmed.ncbi.nlm.nih.gov/10974324 DMGEHZ9 DI DMGEHZ9 DMGEHZ9 DN NNC-09-0026 DMGEHZ9 MI TT5HONZ DMGEHZ9 MN Calcium channel unspecific (CaC) DMGEHZ9 MT DTT DMGEHZ9 MA Modulator DMGEHZ9 RN Pharmacological profile of a novel neuronal calcium channel blocker includes reduced cerebral damage and neurological deficits in rat focal ischemia. Pharmacol Biochem Behav. 1994 May;48(1):77-85. DMGEHZ9 RU https://pubmed.ncbi.nlm.nih.gov/8029306 DMMOAN0 DI DMMOAN0 DMMOAN0 DN NNC-13-8119 DMMOAN0 MI TTPTXIN DMMOAN0 MN Translocator protein (TSPO) DMMOAN0 MT DTT DMMOAN0 MA Modulator DMMOAN0 RN Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800004060) DMMOAN0 RU http://adisinsight.springer.com/drugs/800004060 DMK7BV9 DI DMK7BV9 DMK7BV9 DN NNC-22-0031 DMK7BV9 MI TTZFYLI DMK7BV9 MN Dopamine D1 receptor (D1R) DMK7BV9 MT DTT DMK7BV9 MA Modulator DMK7BV9 RN NNC-19-1228 and NNC 22-0031, novel neuroleptics with a "mesolimbic-selective" behavioral profile. Psychopharmacology (Berl). 1997 Jan;129(2):168-78. DMK7BV9 RU https://pubmed.ncbi.nlm.nih.gov/9040123 DMK7BV9 DI DMK7BV9 DMK7BV9 DN NNC-22-0031 DMK7BV9 MI TTEX248 DMK7BV9 MN Dopamine D2 receptor (D2R) DMK7BV9 MT DTT DMK7BV9 MA Modulator DMK7BV9 RN NNC-19-1228 and NNC 22-0031, novel neuroleptics with a "mesolimbic-selective" behavioral profile. Psychopharmacology (Berl). 1997 Jan;129(2):168-78. DMK7BV9 RU https://pubmed.ncbi.nlm.nih.gov/9040123 DM0BYU2 DI DM0BYU2 DM0BYU2 DN NNC-252504 DM0BYU2 MI TT9O6WS DM0BYU2 MN Glucagon receptor (GCGR) DM0BYU2 MT DTT DM0BYU2 MA Antagonist DM0BYU2 RN A novel glucagon receptor antagonist, NNC 25-0926, blunts hepatic glucose production in the conscious dog. J Pharmacol Exp Ther. 2007 May;321(2):743-52. DM0BYU2 RU https://pubmed.ncbi.nlm.nih.gov/17308040 DMLTYFI DI DMLTYFI DMLTYFI DN NNC-26-0762 DMLTYFI MI TTG4R8V DMLTYFI MN Growth hormone-releasing hormone receptor (GHRHR) DMLTYFI MT DTT DMLTYFI MA Agonist DMLTYFI RN Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800010046) DMLTYFI RU http://adisinsight.springer.com/drugs/800010046 DM1SXG9 DI DM1SXG9 DM1SXG9 DN NNC-90-0270 DM1SXG9 MI TTJSZTB DM1SXG9 MN Nicotinic acetylcholine receptor (nAChR) DM1SXG9 MT DTT DM1SXG9 MA Agonist DM1SXG9 RN Nicotinic agonists, antagonists, and modulators from natural sources. Cell Mol Neurobiol. 2005 Jun;25(3-4):513-52. DM1SXG9 RU https://pubmed.ncbi.nlm.nih.gov/16075378 DMX24FM DI DMX24FM DMX24FM DN Nomifensine DMX24FM MI DEBMX7C DMX24FM MN Dimethylaniline oxidase 5 (FMO5) DMX24FM MT DME DMX24FM MA Metabolism DMX24FM RN Drug metabolism by flavin-containing monooxygenases of human and mouse. Expert Opin Drug Metab Toxicol. 2017 Feb;13(2):167-181. DMX24FM RU https://pubmed.ncbi.nlm.nih.gov/27678284 DM78P4X DI DM78P4X DM78P4X DN NOX-200 DM78P4X MI TTB6H2S DM78P4X MN Amino acid transporter ATB0+ (SLC6A14) DM78P4X MT DTT DM78P4X MA Inhibitor DM78P4X RN Interaction of tryptophan derivatives with SLC6A14 (ATB0,+) reveals the potential of the transporter as a drug target for cancer chemotherapy. Biochem J. 2008 Sep 15;414(3):343-55. DM78P4X RU https://pubmed.ncbi.nlm.nih.gov/18522536 DM78P4X DI DM78P4X DM78P4X DN NOX-200 DM78P4X MI TT5U0XA DM78P4X MN Solute carrier family 36 member 2 (SLC36A2) DM78P4X MT DTT DM78P4X MA Inhibitor DM78P4X RN Amino acid derivatives are substrates or non-transported inhibitors of the amino acid transporter PAT2 (slc36a2). Biochim Biophys Acta. 2011 Jan;1808(1):260-70. DM78P4X RU https://pubmed.ncbi.nlm.nih.gov/20691150 DM4B1VF DI DM4B1VF DM4B1VF DN NP-7557 DM4B1VF MI TT1RS9F DM4B1VF MN Acetylcholinesterase (AChE) DM4B1VF MT DTT DM4B1VF MA Inhibitor DM4B1VF RN Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800017551) DM4B1VF RU http://adisinsight.springer.com/drugs/800017551 DM35RTJ DI DM35RTJ DM35RTJ DN NPC-16377 DM35RTJ MI TT5TPI6 DM35RTJ MN Opioid receptor sigma 1 (OPRS1) DM35RTJ MT DTT DM35RTJ MA Modulator DM35RTJ RN Effects of the selective sigma receptor ligand, 6-[6-(4-hydroxypiperidinyl)hexyloxy]-3-methylflavone (NPC 16377), on behavioral and toxic effects of cocaine. J Pharmacol Exp Ther. 1993 Aug;266(2):473-82. DM35RTJ RU https://pubmed.ncbi.nlm.nih.gov/8355185 DMGVIZY DI DMGVIZY DMGVIZY DN NPC-17731 DMGVIZY MI TTGY8IW DMGVIZY MN B2 bradykinin receptor (BDKRB2) DMGVIZY MT DTT DMGVIZY MA Antagonist DMGVIZY RN Antinociceptive profile of the pseudopeptide B2 bradykinin receptor antagonist NPC 18688 in mice. Br J Pharmacol. 1996 Feb;117(3):552-558. DMGVIZY RU https://pubmed.ncbi.nlm.nih.gov/8821548 DMD01GK DI DMD01GK DMD01GK DN NPC-17923 DMD01GK MI TTD26RC DMD01GK MN Cell adhesion molecule (CADM) DMD01GK MT DTT DMD01GK MA Modulator DMD01GK RN Inhibition of platelet-activating factor-induced leukocyte adhesion in vivo by a leumedin. Eur J Pharmacol. 1993 Mar 2;232(2-3):169-72. DMD01GK RU https://pubmed.ncbi.nlm.nih.gov/8467855 DMAIH90 DI DMAIH90 DMAIH90 DN NPC-18166 DMAIH90 MI TTYSN63 DMAIH90 MN 5-HT 2 receptor (5HT2R) DMAIH90 MT DTT DMAIH90 MA Modulator DMAIH90 RN WO patent application no. 2004,0825,84, 5ht2c receptor antagonists in the treatment of schizophrenia. DMAIH90 RU http://www.google.nl/patents/WO2004082584A2?cl=en DMH1YL8 DI DMH1YL8 DMH1YL8 DN NPI-1999 DMH1YL8 MI TTEMV5X DMH1YL8 MN Serine protease unspecific (SP) DMH1YL8 MT DTT DMH1YL8 MA Inhibitor DMH1YL8 RN US patent application no. 2005,0096,323, Diketopiperazine derivatives to inhibit thrombin. DMH1YL8 RU http://www.google.com/patents/US20050096323 DMTWXE3 DI DMTWXE3 DMTWXE3 DN NPS-1392 DMTWXE3 MI TT9IK2Z DMTWXE3 MN N-methyl-D-aspartate receptor (NMDAR) DMTWXE3 MT DTT DMTWXE3 MA Antagonist DMTWXE3 RN Synthesis, biological activity, and absolute stereochemical assignment of NPS 1392: a potent and stereoselective NMDA receptor antagonist. Bioorg Med Chem Lett. 1999 Jul 19;9(14):1915-20. DMTWXE3 RU https://pubmed.ncbi.nlm.nih.gov/10450953 DMNL1VM DI DMNL1VM DMNL1VM DN NPS-846 DMNL1VM MI TTDXZ24 DMNL1VM MN Glutamate receptor ionotropic (GRI) DMNL1VM MT DTT DMNL1VM MA Modulator DMNL1VM RN Neuroprotective effects of NPS 846, a novel N-methyl-D-aspartate receptor antagonist, after closed head trauma in rats. J Neurosurg. 1998 Jun;88(6):1066-74. DMNL1VM RU https://pubmed.ncbi.nlm.nih.gov/9609302 DMCHLJ4 DI DMCHLJ4 DMCHLJ4 DN NS-004 DMCHLJ4 MI TT1VOHK DMCHLJ4 MN Potassium channel unspecific (KC) DMCHLJ4 MT DTT DMCHLJ4 MA Opener DMCHLJ4 RN Effects of K+ channel inhibitors and antagonists on NS-004 evoked relaxations in guinea-pig isolated trachea. Fundam Clin Pharmacol. 1997;11(1):78-82. DMCHLJ4 RU https://pubmed.ncbi.nlm.nih.gov/9182080 DM75DZ1 DI DM75DZ1 DM75DZ1 DN NS-1546 DM75DZ1 MI TT1VOHK DM75DZ1 MN Potassium channel unspecific (KC) DM75DZ1 MT DTT DM75DZ1 MA Opener DM75DZ1 RN Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800006187) DM75DZ1 RU http://adisinsight.springer.com/drugs/800006187 DMYV9M1 DI DMYV9M1 DMYV9M1 DN NS-1608 DMYV9M1 MI TT1VOHK DMYV9M1 MN Potassium channel unspecific (KC) DMYV9M1 MT DTT DMYV9M1 MA Opener DMYV9M1 RN Modulation of the Ca(2+)-dependent K+ channel, hslo, by the substituted diphenylurea NS 1608, paxilline and internal Ca2+. Neuropharmacology. 1996;35(7):903-14. DMYV9M1 RU https://pubmed.ncbi.nlm.nih.gov/8938721 DMES0OT DI DMES0OT DMES0OT DN NS-1619 DMES0OT MI TT1AQ50 DMES0OT MN Charybdotoxin receptor beta-4 (BKbeta4) DMES0OT MT DTT DMES0OT MA Modulator DMES0OT RN BK channel activation by NS-1619 is partially mediated by intracellular Ca2+ release in smooth muscle cells of porcine coronary artery DMES0OT RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1572625 DM9F81Z DI DM9F81Z DM9F81Z DN NS-257 DM9F81Z MI TTAN6JD DM9F81Z MN Glutamate receptor AMPA (GRIA) DM9F81Z MT DTT DM9F81Z MA Antagonist DM9F81Z RN Characterization of the binding of [3H]NS 257, a novel competitive AMPA receptor antagonist, to rat brain membranes and brain sections. J Neurochem. 1995 Sep;65(3):1264-73. DM9F81Z RU https://pubmed.ncbi.nlm.nih.gov/7543932 DM19OGY DI DM19OGY DM19OGY DN NS-2979 DM19OGY MI TTPTXIN DM19OGY MN Translocator protein (TSPO) DM19OGY MT DTT DM19OGY MA Modulator DM19OGY RN Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800013494) DM19OGY RU http://adisinsight.springer.com/drugs/800013494 DM2MU98 DI DM2MU98 DM2MU98 DN NS-377 DM2MU98 MI TTAN6JD DM2MU98 MN Glutamate receptor AMPA (GRIA) DM2MU98 MT DTT DM2MU98 MA Antagonist DM2MU98 RN In vivo and in vitro evaluation of AMPA receptor antagonists in rat hippocampal neurones and cultured mouse cortical neurones. Eur J Pharmacol. 1998 Jul 24;353(2-3):159-67. DM2MU98 RU https://pubmed.ncbi.nlm.nih.gov/9726646 DMINUWH DI DMINUWH DMINUWH DN NS398 DMINUWH MI TTVKILB DMINUWH MN Prostaglandin G/H synthase 2 (COX-2) DMINUWH MT DTT DMINUWH MA Inhibitor DMINUWH RN New drugs in development for the treatment of endometriosis. Expert Opin Investig Drugs. 2008 Aug;17(8):1187-202. DMINUWH RU https://pubmed.ncbi.nlm.nih.gov/18616415 DMPT74G DI DMPT74G DMPT74G DN NS-638 DMPT74G MI TT5HONZ DMPT74G MN Calcium channel unspecific (CaC) DMPT74G MT DTT DMPT74G MA Modulator DMPT74G RN Pharmacological profile and anti-ischemic properties of the Ca(2+)-channel blocker NS-638. Neurol Res. 1995 Oct;17(5):353-60. DMPT74G RU https://pubmed.ncbi.nlm.nih.gov/8584126 DMXKMRV DI DMXKMRV DMXKMRV DN NS-649 DMXKMRV MI TT5HONZ DMXKMRV MN Calcium channel unspecific (CaC) DMXKMRV MT DTT DMXKMRV MA Modulator DMXKMRV RN Effects of Ca2+ and Na+ channel inhibitors in vitro and in global cerebral ischaemia in vivo. Eur J Pharmacol. 1997 Aug 6;332(2):121-31. DMXKMRV RU https://pubmed.ncbi.nlm.nih.gov/9286613 DMI46T3 DI DMI46T3 DMI46T3 DN NS-696 DMI46T3 MI TT5HONZ DMI46T3 MN Calcium channel unspecific (CaC) DMI46T3 MT DTT DMI46T3 MA Modulator DMI46T3 RN Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800005355) DMI46T3 RU http://adisinsight.springer.com/drugs/800005355 DMEYMHB DI DMEYMHB DMEYMHB DN NSC-303812 DMEYMHB MI DE4LYSA DMEYMHB MN Cytochrome P450 3A4 (CYP3A4) DMEYMHB MT DME DMEYMHB MA Metabolism DMEYMHB RN The mechanism of aphidicolin bioinactivation by rat liver in vitro systems. Xenobiotica. 1990 Mar;20(3):273-87. DMEYMHB RU https://www.ncbi.nlm.nih.gov/pubmed/?term=2110702 DMDJT7U DI DMDJT7U DMDJT7U DN NSC-661755 DMDJT7U MI TT12ABZ DMDJT7U MN Arachidonate 12-lipoxygenase (12-LOX) DMDJT7U MT DTT DMDJT7U MA Inhibitor DMDJT7U RN Discovery of platelet-type 12-human lipoxygenase selective inhibitors by high-throughput screening of structurally diverse libraries. Bioorg Med Chem. 2007 Nov 15;15(22):6900-8. DMDJT7U RU https://pubmed.ncbi.nlm.nih.gov/17826100 DMDJT7U DI DMDJT7U DMDJT7U DN NSC-661755 DMDJT7U MI TTN9T81 DMDJT7U MN Arachidonate 15-lipoxygenase (15-LOX) DMDJT7U MT DTT DMDJT7U MA Inhibitor DMDJT7U RN Discovery of platelet-type 12-human lipoxygenase selective inhibitors by high-throughput screening of structurally diverse libraries. Bioorg Med Chem. 2007 Nov 15;15(22):6900-8. DMDJT7U RU https://pubmed.ncbi.nlm.nih.gov/17826100 DMF2XMA DI DMF2XMA DMF2XMA DN NSD-721 DMF2XMA MI TTEX6LM DMF2XMA MN GABA(A) receptor gamma-3 (GABRG3) DMF2XMA MT DTT DMF2XMA MA Modulator DMF2XMA RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 415). DMF2XMA RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=415 DMPG703 DI DMPG703 DMPG703 DN NSL-036 DMPG703 MI TTU593I DMPG703 MN Neurokinin receptor (NKR) DMPG703 MT DTT DMPG703 MA Antagonist DMPG703 RN US patent application no. 2008,0039,404, Bifunctional analgesic compounds for opioid receptor agonists and neurokinin-1 receptor antagonists. DMPG703 RU http://www.google.com/patents/US20080039404 DMU3D1K DI DMU3D1K DMU3D1K DN NTE-122 DMU3D1K MI TTMF541 DMU3D1K MN Liver carboxylesterase (CES1) DMU3D1K MT DTT DMU3D1K MA Inhibitor DMU3D1K RN Cholesterol-lowering effects of NTE-122, a novel acyl-CoA:cholesterol acyltransferase (ACAT) inhibitor, on cholesterol diet-fed rats and rabbits. Jpn J Pharmacol. 1998 Nov;78(3):355-64. DMU3D1K RU https://pubmed.ncbi.nlm.nih.gov/9869270 DMPA8WO DI DMPA8WO DMPA8WO DN NU1025 DMPA8WO MI TTVDSZ0 DMPA8WO MN Poly [ADP-ribose] polymerase 1 (PARP1) DMPA8WO MT DTT DMPA8WO MA Inhibitor DMPA8WO RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DMPA8WO RU https://pubmed.ncbi.nlm.nih.gov/10592235 DMINSRW DI DMINSRW DMINSRW DN NZ-1002 DMINSRW MI TT3C1VN DMINSRW MN Enzyme unspecific (Enz) DMINSRW MT DTT DMINSRW MA Modulator DMINSRW RN Expression of a cytokinin synthesis gene from Agrobacterium tumefaciens T-DNA in basket willow (Salix viminalis). Physiologia Plantarum Volume 88, Issue 3, pages 439-445, July 1993. DMINSRW RU http://onlinelibrary.wiley.com/doi/10.1111/j.1399-3054.1993.tb01357.x/abstract?userIsAuthenticated=false&deniedAccessCustomisedMessage= DMNAFG1 DI DMNAFG1 DMNAFG1 DN Olomoucine DMNAFG1 MI TTH6V3D DMNAFG1 MN Cyclin-dependent kinase 1 (CDK1) DMNAFG1 MT DTT DMNAFG1 MA Binder DMNAFG1 RN Antiproliferative activity of olomoucine II, a novel 2,6,9-trisubstituted purine cyclin-dependent kinase inhibitor. Cell Mol Life Sci. 2005 Aug;62(15):1763-71. DMNAFG1 RU https://pubmed.ncbi.nlm.nih.gov/16003486 DMNAFG1 DI DMNAFG1 DMNAFG1 DN Olomoucine DMNAFG1 MI TT7HF4W DMNAFG1 MN Cyclin-dependent kinase 2 (CDK2) DMNAFG1 MT DTT DMNAFG1 MA Inhibitor DMNAFG1 RN Pharmacological inhibitors of cyclin-dependent kinases. Trends Pharmacol Sci. 2002 Sep;23(9):417-25. DMNAFG1 RU https://pubmed.ncbi.nlm.nih.gov/12237154 DMNAFG1 DI DMNAFG1 DMNAFG1 DN Olomoucine DMNAFG1 MI TTL4Q97 DMNAFG1 MN Cyclin-dependent kinase 5 (CDK5) DMNAFG1 MT DTT DMNAFG1 MA Inhibitor DMNAFG1 RN Pharmacological inhibitors of cyclin-dependent kinases. Trends Pharmacol Sci. 2002 Sep;23(9):417-25. DMNAFG1 RU https://pubmed.ncbi.nlm.nih.gov/12237154 DMAGUY0 DI DMAGUY0 DMAGUY0 DN Omapatrilat DMAGUY0 MI TTL69WB DMAGUY0 MN Angiotensin-converting enzyme (ACE) DMAGUY0 MT DTT DMAGUY0 MA Modulator DMAGUY0 RN Omapatrilat, a dual angiotensin-converting enzyme and neutral endopeptidase inhibitor, prevents fatty streak deposit in apolipoprotein E-deficient mice. Atherosclerosis. 2001 Apr;155(2):291-5. DMAGUY0 RU https://pubmed.ncbi.nlm.nih.gov/11254898 DMAGUY0 DI DMAGUY0 DMAGUY0 DN Omapatrilat DMAGUY0 MI TT5TKPM DMAGUY0 MN Neutral endopeptidase (MME) DMAGUY0 MT DTT DMAGUY0 MA Modulator DMAGUY0 RN Omapatrilat, a dual angiotensin-converting enzyme and neutral endopeptidase inhibitor, prevents fatty streak deposit in apolipoprotein E-deficient mice. Atherosclerosis. 2001 Apr;155(2):291-5. DMAGUY0 RU https://pubmed.ncbi.nlm.nih.gov/11254898 DMSKAGP DI DMSKAGP DMSKAGP DN Omniferon DMSKAGP MI TTV2CN0 DMSKAGP MN Interferon receptor (IFNR) DMSKAGP MT DTT DMSKAGP MA Modulator DMSKAGP RN US patent application no. 2004,0229,936, Treatment of hepatitis c virus infection with sesquiterpene lactones. DMSKAGP RU http://www.google.co.ve/patents/US20040229936 DMMLXRG DI DMMLXRG DMMLXRG DN ON-09300 DMMLXRG MI TTVKILB DMMLXRG MN Prostaglandin G/H synthase 2 (COX-2) DMMLXRG MT DTT DMMLXRG MA Modulator DMMLXRG RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. DMMLXRG RU https://www.fda.gov/ DMTS6HB DI DMTS6HB DMTS6HB DN ON-579 DMTS6HB MI TT2O84V DMTS6HB MN Thromboxane A2 receptor (TBXA2R) DMTS6HB MT DTT DMTS6HB MA Modulator DMTS6HB RN The effect of a TXA2 receptor antagonist ON-579 on experimental allergic reactions. Prostaglandins Leukot Essent Fatty Acids. 1995 Aug;53(2):123-33. DMTS6HB RU https://pubmed.ncbi.nlm.nih.gov/7480074 DMBDCL4 DI DMBDCL4 DMBDCL4 DN ONO-8130 DMBDCL4 MI TTG1QMU DMBDCL4 MN Prostaglandin E2 receptor EP1 (PTGER1) DMBDCL4 MT DTT DMBDCL4 MA Modulator DMBDCL4 RN ONO-8130, a selective prostanoid EP1 receptor antagonist, relieves bladder pain in mice with cyclophosphamide-induced cystitis. Pain. 2011 Jun;152(6):1373-81. DMBDCL4 RU https://pubmed.ncbi.nlm.nih.gov/21396778 DM2VRK7 DI DM2VRK7 DM2VRK7 DN ONO-8711 DM2VRK7 MI TTG1QMU DM2VRK7 MN Prostaglandin E2 receptor EP1 (PTGER1) DM2VRK7 MT DTT DM2VRK7 MA Antagonist DM2VRK7 RN Chemopreventive effects of ONO-8711, a selective prostaglandin E receptor EP(1) antagonist, on breast cancer development. Carcinogenesis. 2001 Dec;22(12):2001-4. DM2VRK7 RU https://pubmed.ncbi.nlm.nih.gov/11751431 DM4CVEG DI DM4CVEG DM4CVEG DN ONO-8815Ly DM4CVEG MI TT1ZAVI DM4CVEG MN Prostaglandin E2 receptor EP2 (PTGER2) DM4CVEG MT DTT DM4CVEG MA Agonist DM4CVEG RN Prostaglandin E2 receptor type 2-selective agonist prevents the degeneration of articular cartilage in rabbit knees with traumatic instability. Arthritis Res Ther. 2011;13(5):R146. DM4CVEG RU https://pubmed.ncbi.nlm.nih.gov/21914215 DMW68CE DI DMW68CE DMW68CE DN Oral insulin DMW68CE MI TTZOPHG DMW68CE MN Insulin (INS) DMW68CE MT DTT DMW68CE MA Modulator DMW68CE RN ClinicalTrials.gov (NCT01120912) Safety and Efficacy of Single Administration of Oshadi Oral Insulin in Type I Diabetes Patients. U.S. National Institutes of Health. DMW68CE RU https://clinicaltrials.gov/ct2/show/NCT01120912 DMUGC2X DI DMUGC2X DMUGC2X DN Org-10490 DMUGC2X MI TTZFYLI DMUGC2X MN Dopamine D1 receptor (D1R) DMUGC2X MT DTT DMUGC2X MA Modulator DMUGC2X RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. DMUGC2X RU https://www.fda.gov/ DMUGC2X DI DMUGC2X DMUGC2X DN Org-10490 DMUGC2X MI TTEX248 DMUGC2X MN Dopamine D2 receptor (D2R) DMUGC2X MT DTT DMUGC2X MA Modulator DMUGC2X RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. DMUGC2X RU https://www.fda.gov/ DMQU8AR DI DMQU8AR DMQU8AR DN Org-20599 DMQU8AR MI TTGXH6N DMQU8AR MN GABA(A) receptor delta (GABRD) DMQU8AR MT DTT DMQU8AR MA Modulator DMQU8AR RN The anaesthetic action and modulation of GABAA receptor activity by the novel water-soluble aminosteroid Org 20599. Neuropharmacology. 1996;35(9-10):1209-22. DMQU8AR RU https://pubmed.ncbi.nlm.nih.gov/9014136 DM95QG2 DI DM95QG2 DM95QG2 DN Org-20781 DM95QG2 MI TT1VOHK DM95QG2 MN Potassium channel unspecific (KC) DM95QG2 MT DTT DM95QG2 MA Opener DM95QG2 RN Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800003350) DM95QG2 RU http://adisinsight.springer.com/drugs/800003350 DMMA92L DI DMMA92L DMMA92L DN Org-30035 DMMA92L MI TTN4QDT DMMA92L MN Opioid receptor (OPR) DMMA92L MT DTT DMMA92L MA Modulator DMMA92L RN WO patent application no. 2010,0332,07, Polymer conjugates of therapeutic peptides. DMMA92L RU http://worldwide.espacenet.com/publicationDetails/biblio?DB=worldwide.espacenet.com&II=0&ND=3&adjacent=true&locale=en_EP&FT=D&date=20100325&CC=WO&NR=2010033207A1&KC=A1 DM3VWZF DI DM3VWZF DM3VWZF DN Org-34092 DM3VWZF MI TT6L509 DM3VWZF MN Coagulation factor IIa (F2) DM3VWZF MT DTT DM3VWZF MA Inhibitor DM3VWZF RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2362). DM3VWZF RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2362 DMB0IQT DI DMB0IQT DMB0IQT DN Org-34116 DMB0IQT MI TTYRL6O DMB0IQT MN Glucocorticoid receptor (NR3C1) DMB0IQT MT DTT DMB0IQT MA Antagonist DMB0IQT RN Blockade of glucocorticoid receptors with ORG 34116 does not normalize stress-induced symptoms in male tree shrews. Eur J Pharmacol. 2002 Dec 20;457(2-3):207-16. DMB0IQT RU https://pubmed.ncbi.nlm.nih.gov/12464368 DMY3LXH DI DMY3LXH DMY3LXH DN Org-37684 DMY3LXH MI TTWJBZ5 DMY3LXH MN 5-HT 2C receptor (HTR2C) DMY3LXH MT DTT DMY3LXH MA Agonist DMY3LXH RN Role of 5-hT2C receptors in the hypophagic effect of m-CPP, ORG 37684 and CP-94,253 in the rat. Prog Neuropsychopharmacol Biol Psychiatry. 2002 Apr;26(3):441-9. DMY3LXH RU https://pubmed.ncbi.nlm.nih.gov/11999893 DMRZCH4 DI DMRZCH4 DMRZCH4 DN Org-9935 DMRZCH4 MI TTZCG4L DMRZCH4 MN Phosphodiesterase 3 (PDE3) DMRZCH4 MT DTT DMRZCH4 MA Modulator DMRZCH4 RN The phosphodiesterase 3 inhibitor ORG 9935 inhibits oocyte maturation in the naturally selected dominant follicle in rhesus macaques.Contraception.2008 Apr;77(4):303-7. DMRZCH4 RU https://www.ncbi.nlm.nih.gov/pubmed/18342656 DM9YOMX DI DM9YOMX DM9YOMX DN OT-4003 DM9YOMX MI TTGKOY9 DM9YOMX MN Leukotriene CysLT1 receptor (CYSLTR1) DM9YOMX MT DTT DM9YOMX MA Modulator DM9YOMX RN Discovery of OT4003, a novel, potent, and orally active cys-LT1 receptor antagonist. Bioorg Med Chem. 1997 Feb;5(2):415-27. DM9YOMX RU https://pubmed.ncbi.nlm.nih.gov/9061206 DMESWV1 DI DMESWV1 DMESWV1 DN OX-23 DMESWV1 MI TTN4QDT DMESWV1 MN Opioid receptor (OPR) DMESWV1 MT DTT DMESWV1 RN CA patent application no. 212323, Method for improving gastrointestinal motility. DMESWV1 RU http://www.google.com/patents/CA1212323A1?cl=en DMVPG1N DI DMVPG1N DMVPG1N DN OX-30 DMVPG1N MI TTUS45N DMVPG1N MN Leukocyte common antigen (PTPRC) DMVPG1N MT DTT DMVPG1N RN CD45 / PTPRC Antibody, Biotin conjugate (OX-30). DMVPG1N RU http://www.thermofisher.com/order/genome-database/details/antibody/MA5-17376.html DM1TG3C DI DM1TG3C DM1TG3C DN Oxamflatin DM1TG3C MI TT6R7JZ DM1TG3C MN Histone deacetylase 1 (HDAC1) DM1TG3C MT DTT DM1TG3C MA Inhibitor DM1TG3C RN Histone deacetylase inhibitors in cancer therapy: latest developments, trends and medicinal chemistry perspective. Anticancer Agents Med Chem. 2007 Sep;7(5):576-92. DM1TG3C RU https://pubmed.ncbi.nlm.nih.gov/17896917 DMLKQUR DI DMLKQUR DMLKQUR DN Palinavir DMLKQUR MI TT5FNQT DMLKQUR MN Human immunodeficiency virus Protease (HIV PR) DMLKQUR MT DTT DMLKQUR MA Modulator DMLKQUR RN Antiviral properties of palinavir, a potent inhibitor of the human immunodeficiency virus type 1 protease. Antimicrob Agents Chemother. 1997 May;41(5):965-71. DMLKQUR RU https://pubmed.ncbi.nlm.nih.gov/9145853 DM6HBQJ DI DM6HBQJ DM6HBQJ DN Patamostat DM6HBQJ MI TT2WR1T DM6HBQJ MN Cationic trypsinogen (PRSS1) DM6HBQJ MT DTT DM6HBQJ MA Modulator DM6HBQJ RN US patent application no. 2012,0251,516, PHARMACEUTICAL COMPOSITION FOR TREATING CANCER COMPRISING TRYPSINOGEN AND/OR CHYMOTRYPSINOGEN AND AN ACTIVE AGENT SELECTED FROM A SELENIUM COMPOUND, A VANILLOID COMPOUND AND A CYTOPLASMIC GLYCOLYSIS REDUCTION AGENT. DM6HBQJ RU http://www.patentbuddy.com/Patent/20120251516?ft=true&sr=true DMWD1RC DI DMWD1RC DMWD1RC DN PBI-1101 DMWD1RC MI TT3NKIB DMWD1RC MN Pancreatic elastase 1 (CELA1) DMWD1RC MT DTT DMWD1RC MA Inhibitor DMWD1RC RN CN patent application no. 1813706, Use of elastic protease inhibitor for preparing medicine for protecting cerebral hemorrhage. DMWD1RC RU http://www.google.com/patents/CN1813706A?cl=en DMWYP86 DI DMWYP86 DMWYP86 DN PD-0183812 DMWYP86 MI TTAMQ62 DMWYP86 MN Cyclin A2 (CCNA2) DMWYP86 MT DTT DMWYP86 MA Inhibitor DMWYP86 RN Pyrido[2,3-d]pyrimidin-7-one inhibitors of cyclin-dependent kinases. J Med Chem. 2000 Nov 30;43(24):4606-16. DMWYP86 RU https://pubmed.ncbi.nlm.nih.gov/11101352 DMWYP86 DI DMWYP86 DMWYP86 DN PD-0183812 DMWYP86 MI TT7HF4W DMWYP86 MN Cyclin-dependent kinase 2 (CDK2) DMWYP86 MT DTT DMWYP86 MA Inhibitor DMWYP86 RN Pyrido[2,3-d]pyrimidin-7-one inhibitors of cyclin-dependent kinases. J Med Chem. 2000 Nov 30;43(24):4606-16. DMWYP86 RU https://pubmed.ncbi.nlm.nih.gov/11101352 DMWYP86 DI DMWYP86 DMWYP86 DN PD-0183812 DMWYP86 MI TT0PG8F DMWYP86 MN Cyclin-dependent kinase 4 (CDK4) DMWYP86 MT DTT DMWYP86 MA Inhibitor DMWYP86 RN Pharmacological inhibitors of cyclin-dependent kinases. Trends Pharmacol Sci. 2002 Sep;23(9):417-25. DMWYP86 RU https://pubmed.ncbi.nlm.nih.gov/12237154 DMWYP86 DI DMWYP86 DMWYP86 DN PD-0183812 DMWYP86 MI TTO0FDJ DMWYP86 MN Cyclin-dependent kinase 6 (CDK6) DMWYP86 MT DTT DMWYP86 MA Inhibitor DMWYP86 RN Pharmacological inhibitors of cyclin-dependent kinases. Trends Pharmacol Sci. 2002 Sep;23(9):417-25. DMWYP86 RU https://pubmed.ncbi.nlm.nih.gov/12237154 DMWYP86 DI DMWYP86 DMWYP86 DN PD-0183812 DMWYP86 MI TT1KX2S DMWYP86 MN FGFR4 messenger RNA (FGFR4 mRNA) DMWYP86 MT DTT DMWYP86 MA Inhibitor DMWYP86 RN Pyrido[2,3-d]pyrimidin-7-one inhibitors of cyclin-dependent kinases. J Med Chem. 2000 Nov 30;43(24):4606-16. DMWYP86 RU https://pubmed.ncbi.nlm.nih.gov/11101352 DMWYP86 DI DMWYP86 DMWYP86 DN PD-0183812 DMWYP86 MI TTRLW2X DMWYP86 MN Fibroblast growth factor receptor 1 (FGFR1) DMWYP86 MT DTT DMWYP86 MA Inhibitor DMWYP86 RN Pyrido[2,3-d]pyrimidin-7-one inhibitors of cyclin-dependent kinases. J Med Chem. 2000 Nov 30;43(24):4606-16. DMWYP86 RU https://pubmed.ncbi.nlm.nih.gov/11101352 DMWYP86 DI DMWYP86 DMWYP86 DN PD-0183812 DMWYP86 MI TTGJVQM DMWYP86 MN Fibroblast growth factor receptor 2 (FGFR2) DMWYP86 MT DTT DMWYP86 MA Inhibitor DMWYP86 RN Pyrido[2,3-d]pyrimidin-7-one inhibitors of cyclin-dependent kinases. J Med Chem. 2000 Nov 30;43(24):4606-16. DMWYP86 RU https://pubmed.ncbi.nlm.nih.gov/11101352 DMWYP86 DI DMWYP86 DMWYP86 DN PD-0183812 DMWYP86 MI TTST7KB DMWYP86 MN Fibroblast growth factor receptor 3 (FGFR3) DMWYP86 MT DTT DMWYP86 MA Inhibitor DMWYP86 RN Pyrido[2,3-d]pyrimidin-7-one inhibitors of cyclin-dependent kinases. J Med Chem. 2000 Nov 30;43(24):4606-16. DMWYP86 RU https://pubmed.ncbi.nlm.nih.gov/11101352 DMWYP86 DI DMWYP86 DMWYP86 DN PD-0183812 DMWYP86 MI TTCEJ4F DMWYP86 MN G1/S-specific cyclin-E1 (CCNE1) DMWYP86 MT DTT DMWYP86 MA Inhibitor DMWYP86 RN Pyrido[2,3-d]pyrimidin-7-one inhibitors of cyclin-dependent kinases. J Med Chem. 2000 Nov 30;43(24):4606-16. DMWYP86 RU https://pubmed.ncbi.nlm.nih.gov/11101352 DMGKVPH DI DMGKVPH DMGKVPH DN PD-0204318 DMGKVPH MI TT4FDG6 DMGKVPH MN Voltage-gated calcium channel alpha Cav2.2 (CACNA1B) DMGKVPH MT DTT DMGKVPH MA Antagonist DMGKVPH RN US patent application no. 2012,0172,429, Permanently charged sodium and calcium channel blockers as anti- inflammatory agents. DMGKVPH RU http://www.google.com/Patents/US20120172429 DMN1A70 DI DMN1A70 DMN1A70 DN PD-117596 DMN1A70 MI TTN6J5F DMN1A70 MN Bacterial DNA gyrase (Bact gyrase) DMN1A70 MT DTT DMN1A70 MA Modulator DMN1A70 RN In vitro antibacterial activities of the fluoroquinolones PD 117596, PD 124816, and PD 127391. Diagn Microbiol Infect Dis. 1991 May-Jun;14(3):245-58. DMN1A70 RU https://www.ncbi.nlm.nih.gov/pubmed/1889177 DM92VUF DI DM92VUF DM92VUF DN PD-123319 DM92VUF MI TTQVOEI DM92VUF MN Angiotensin II receptor type-2 (AGTR2) DM92VUF MT DTT DM92VUF MA Inhibitor DM92VUF RN Synthesis and structure-activity relationships of a novel series of non-peptide angiotensin II receptor binding inhibitors specific for the AT2 sub... J Med Chem. 1991 Nov;34(11):3248-60. DM92VUF RU https://pubmed.ncbi.nlm.nih.gov/1956044 DM0YXRQ DI DM0YXRQ DM0YXRQ DN PD-128483 DM0YXRQ MI TTEX248 DM0YXRQ MN Dopamine D2 receptor (D2R) DM0YXRQ MT DTT DM0YXRQ MA Inhibitor DM0YXRQ RN Synthesis and pharmacological evaluation of the enantiomers of the dopamine autoreceptor agonist PD 135385, Bioorg. Med. Chem. Lett. 3(4):639-644 (1993). DM0YXRQ RU http://www.sciencedirect.com/science/article/pii/S0960894X01812452 DMLEVNC DI DMLEVNC DMLEVNC DN PD-135666 DMLEVNC MI TTCG0AL DMLEVNC MN Cholecystokinin receptor type A (CCKAR) DMLEVNC MT DTT DMLEVNC MA Inhibitor DMLEVNC RN Selective ligands for cholecystokinin receptor subtypes CCK-A and CCK-B within a single structural class, Bioorg. Med. Chem. Lett. 3(5):881-884 (1993). DMLEVNC RU http://www.sciencedirect.com/science/article/pii/S0960894X0080685X DMLEVNC DI DMLEVNC DMLEVNC DN PD-135666 DMLEVNC MI TTVFO0U DMLEVNC MN Gastrin/cholecystokinin type B receptor (CCKBR) DMLEVNC MT DTT DMLEVNC MA Inhibitor DMLEVNC RN Selective ligands for cholecystokinin receptor subtypes CCK-A and CCK-B within a single structural class, Bioorg. Med. Chem. Lett. 3(5):881-884 (1993). DMLEVNC RU http://www.sciencedirect.com/science/article/pii/S0960894X0080685X DMD6L82 DI DMD6L82 DMD6L82 DN PD136450 DMD6L82 MI TTVFO0U DMD6L82 MN Gastrin/cholecystokinin type B receptor (CCKBR) DMD6L82 MT DTT DMD6L82 MA Antagonist DMD6L82 RN Cholecystokinin type B receptor antagonist PD-136,450 is a partial secretory agonist in the stomach and a full agonist in the pancreas of the rat. Gut. 1994 Feb;35(2):270-4. DMD6L82 RU https://pubmed.ncbi.nlm.nih.gov/8307482 DMFA27N DI DMFA27N DMFA27N DN PD142893 DMFA27N MI TTKRD0G DMFA27N MN Endothelin A receptor (EDNRA) DMFA27N MT DTT DMFA27N MA Antagonist DMFA27N RN Human optic nerve head astrocytes as a target for endothelin-1. Invest Ophthalmol Vis Sci. 2002 Aug;43(8):2704-13. DMFA27N RU https://pubmed.ncbi.nlm.nih.gov/12147606 DMFA27N DI DMFA27N DMFA27N DN PD142893 DMFA27N MI TT3ZTGU DMFA27N MN Endothelin B receptor (EDNRB) DMFA27N MT DTT DMFA27N MA Antagonist DMFA27N RN Human optic nerve head astrocytes as a target for endothelin-1. Invest Ophthalmol Vis Sci. 2002 Aug;43(8):2704-13. DMFA27N RU https://pubmed.ncbi.nlm.nih.gov/12147606 DMHQSF8 DI DMHQSF8 DMHQSF8 DN PD-146176 DMHQSF8 MI TT2J34L DMHQSF8 MN Arachidonate 5-lipoxygenase (5-LOX) DMHQSF8 MT DTT DMHQSF8 MA Modulator DMHQSF8 RN A specific 15-lipoxygenase inhibitor limits the progression and monocyte-macrophage enrichment of hypercholesterolemia-induced atherosclerosis in the rabbit.Atherosclerosis.1998 Feb;136(2):203-16. DMHQSF8 RU https://www.ncbi.nlm.nih.gov/pubmed/9543090 DMVEXID DI DMVEXID DMVEXID DN PD-153103 DMVEXID MI TT5FNQT DMVEXID MN Human immunodeficiency virus Protease (HIV PR) DMVEXID MT DTT DMVEXID MA Modulator DMVEXID RN US patent application no. 2008,0161,324, Compositions and methods for treatment of viral diseases. DMVEXID RU http://www.google.com/patents/US20080161324 DMQCNWD DI DMQCNWD DMQCNWD DN PD-155080 DMQCNWD MI TTKRD0G DMQCNWD MN Endothelin A receptor (EDNRA) DMQCNWD MT DTT DMQCNWD MA Modulator DMQCNWD RN Potency of PD155080, an orally active ETA receptor antagonist, determined for human endothelin receptors. J Cardiovasc Pharmacol. 1995;26 Suppl 3:S362-4. DMQCNWD RU https://www.ncbi.nlm.nih.gov/pubmed/8587415 DMAVZEJ DI DMAVZEJ DMAVZEJ DN PD156707 DMAVZEJ MI TTKRD0G DMAVZEJ MN Endothelin A receptor (EDNRA) DMAVZEJ MT DTT DMAVZEJ MA Antagonist DMAVZEJ RN Discovery and development of an endothelin A receptor-selective antagonist PD 156707. Pharm Biotechnol. 1998;11:81-112. DMAVZEJ RU https://pubmed.ncbi.nlm.nih.gov/9760677 DM61NFD DI DM61NFD DM61NFD DN PD-157667 DM61NFD MI TT4FDG6 DM61NFD MN Voltage-gated calcium channel alpha Cav2.2 (CACNA1B) DM61NFD MT DTT DM61NFD MA Inhibitor DM61NFD RN Synthesis and biological activity of substituted bis-(4-hydroxyphenyl)methanes as N-type calcium channel blockers. Bioorg Med Chem Lett. 1999 Aug 16;9(16):2447-52. DM61NFD RU https://pubmed.ncbi.nlm.nih.gov/10476885 DMS1XK5 DI DMS1XK5 DMS1XK5 DN PD-158473 DMS1XK5 MI TT9IK2Z DMS1XK5 MN N-methyl-D-aspartate receptor (NMDAR) DMS1XK5 MT DTT DMS1XK5 MA Modulator DMS1XK5 RN Improved intestinal transport of PD 158473, an N-methyl-D-aspartate (NMDA) antagonist, by involvement of multiple transporters. J Pharm Sci. 2002 Dec;91(12):2579-87. DMS1XK5 RU https://pubmed.ncbi.nlm.nih.gov/12434401 DMJ5STO DI DMJ5STO DMJ5STO DN PD-159913 DMJ5STO MI TT9IK2Z DMJ5STO MN N-methyl-D-aspartate receptor (NMDAR) DMJ5STO MT DTT DMJ5STO MA Modulator DMJ5STO RN WO patent application no. 2009,0164,86, Use of nmda receptor antagonists for treatment of urologic tumors. DMJ5STO RU http://worldwide.espacenet.com/publicationDetails/biblio?DB=worldwide.espacenet.com&II=0&ND=3&adjacent=true&locale=en_EP&FT=D&date=20090205&CC=WO&NR=2009016486A2&KC=A2 DMAOHXY DI DMAOHXY DMAOHXY DN PD166285 DMAOHXY MI TT6PKBN DMAOHXY MN Proto-oncogene c-Src (SRC) DMAOHXY MT DTT DMAOHXY MA Inhibitor DMAOHXY RN Anti-angiogenic activity of selected receptor tyrosine kinase inhibitors, PD166285 and PD173074: implications for combination treatment with photodynamic therapy. Invest New Drugs. 1999;17(2):121-35. DMAOHXY RU https://pubmed.ncbi.nlm.nih.gov/10638483 DMQRHMT DI DMQRHMT DMQRHMT DN PD-29361 DMQRHMT MI TT4FDG6 DMQRHMT MN Voltage-gated calcium channel alpha Cav2.2 (CACNA1B) DMQRHMT MT DTT DMQRHMT MA Inhibitor DMQRHMT RN Synthesis and structure-activity relationship of substituted 1,2,3,4-tetrahydroisoquinolines as N-type calcium channel blockers. Bioorg Med Chem Lett. 1998 Sep 22;8(18):2415-8. DMQRHMT RU https://pubmed.ncbi.nlm.nih.gov/9873552 DMNUKB4 DI DMNUKB4 DMNUKB4 DN PD-85639 DMNUKB4 MI TTRK8B9 DMNUKB4 MN Sodium channel unspecific (NaC) DMNUKB4 MT DTT DMNUKB4 MA Inhibitor DMNUKB4 RN Medicinal chemistry of neuronal voltage-gated sodium channel blockers. J Med Chem. 2001 Jan 18;44(2):115-37. DMNUKB4 RU https://pubmed.ncbi.nlm.nih.gov/11170622 DMNUKB4 DI DMNUKB4 DMNUKB4 DN PD-85639 DMNUKB4 MI TTAXZ0K DMNUKB4 MN Voltage-gated sodium channel alpha Nav1.3 (SCN3A) DMNUKB4 MT DTT DMNUKB4 MA Inhibitor DMNUKB4 RN Synthesis and pharmacological evaluation of phenylacetamides as sodium-channel blockers. J Med Chem. 1994 Jan 21;37(2):268-74. DMNUKB4 RU https://pubmed.ncbi.nlm.nih.gov/8295214 DMNUKB4 DI DMNUKB4 DMNUKB4 DN PD-85639 DMNUKB4 MI TTZOVE0 DMNUKB4 MN Voltage-gated sodium channel alpha Nav1.5 (SCN5A) DMNUKB4 MT DTT DMNUKB4 MA Inhibitor DMNUKB4 RN Medicinal chemistry of neuronal voltage-gated sodium channel blockers. J Med Chem. 2001 Jan 18;44(2):115-37. DMNUKB4 RU https://pubmed.ncbi.nlm.nih.gov/11170622 DMT819N DI DMT819N DMT819N DN Pegorgotein DMT819N MI TT6RVLG DMT819N MN Superoxide dismutase Cu-Zn (SOD Cu-Zn) DMT819N MT DTT DMT819N MA Modulator DMT819N RN Clinical trials with Dismutec (pegorgotein; polyethylene glycol-conjugated superoxide dismutase; PEG-SOD) in the treatment of severe closed head injury. Adv Exp Med Biol. 1994;366:389-400. DMT819N RU https://pubmed.ncbi.nlm.nih.gov/7771267 DM9S1EA DI DM9S1EA DM9S1EA DN Pepstatin DM9S1EA MI TTJNPTK DM9S1EA MN Plasmodium Cysteine protease falcipain (Malaria CPF) DM9S1EA MT DTT DM9S1EA MA Inhibitor DM9S1EA RN Novel molecular targets for antimalarial chemotherapy. Int J Antimicrob Agents. 2007 Jul;30(1):4-10. DM9S1EA RU https://pubmed.ncbi.nlm.nih.gov/17339102 DM9S1EA DI DM9S1EA DM9S1EA DN Pepstatin DM9S1EA MI TT7EASG DM9S1EA MN Plasmodium Cysteine protease falcipain-2 (Malaria CPF2) DM9S1EA MT DTT DM9S1EA MA Inhibitor DM9S1EA RN Novel molecular targets for antimalarial drug development. Chem Biol Drug Des. 2008 Apr;71(4):287-97. DM9S1EA RU https://pubmed.ncbi.nlm.nih.gov/18298458 DM9S1EA DI DM9S1EA DM9S1EA DN Pepstatin DM9S1EA MI TTH9VL3 DM9S1EA MN Plasmodium Plasmepsin 1 (Malaria PLA1) DM9S1EA MT DTT DM9S1EA MA Inhibitor DM9S1EA RN Novel molecular targets for antimalarial chemotherapy. Int J Antimicrob Agents. 2007 Jul;30(1):4-10. DM9S1EA RU https://pubmed.ncbi.nlm.nih.gov/17339102 DM9S1EA DI DM9S1EA DM9S1EA DN Pepstatin DM9S1EA MI TTXMNHO DM9S1EA MN Plasmodium Plasmepsin 2 (Malaria PLA2) DM9S1EA MT DTT DM9S1EA MA Inhibitor DM9S1EA RN Novel molecular targets for antimalarial chemotherapy. Int J Antimicrob Agents. 2007 Jul;30(1):4-10. DM9S1EA RU https://pubmed.ncbi.nlm.nih.gov/17339102 DMOS9NZ DI DMOS9NZ DMOS9NZ DN PF-03882845 DMOS9NZ MI TT26PHO DMOS9NZ MN Mineralocorticoid receptor (MR) DMOS9NZ MT DTT DMOS9NZ MA Modulator DMOS9NZ RN Discovery of (3S,3aR)-2-(3-chloro-4-cyanophenyl)-3-cyclopentyl-3,3a,4,5-tetrahydro-2H-benzo[g] indazole-7-carboxylic acid (PF-3882845), an orally efficacious mineralocorticoid receptor (MR) antagonist for hypertension and nephropathy.J Med Chem.2010 Aug 26;53(16):5979-6002. DMOS9NZ RU https://www.ncbi.nlm.nih.gov/pubmed/20672822 DMSNOH3 DI DMSNOH3 DMSNOH3 DN PF-04620110 DMSNOH3 MI TTF8P9I DMSNOH3 MN Diacylglycerol acyltransferase 1 (DGAT1) DMSNOH3 MT DTT DMSNOH3 MA Inhibitor DMSNOH3 RN Clinical pipeline report, company report or official report of Pfizer (2011). DMSNOH3 RU http://www.pfizer.com/home/ DMZ8HW7 DI DMZ8HW7 DMZ8HW7 DN PF-572778 DMZ8HW7 MI TTIY658 DMZ8HW7 MN Corticotropin-releasing factor receptor 2 (CRHR2) DMZ8HW7 MT DTT DMZ8HW7 MA Modulator DMZ8HW7 RN WO patent application no. 2013,1603,15, Genetic predictors of response to treatment with crhr1 antagonists. DMZ8HW7 RU http://worldwide.espacenet.com/publicationDetails/biblio?DB=worldwide.espacenet.com&II=0&ND=3&adjacent=true&locale=en_EP&FT=D&date=20131031&CC=WO&NR=2013160315A2&KC=A2 DMAJ9ZD DI DMAJ9ZD DMAJ9ZD DN Phosphonate DMAJ9ZD MI TT1UZQH DMAJ9ZD MN Phospholipase C (PLC) DMAJ9ZD MT DTT DMAJ9ZD MA Inhibitor DMAJ9ZD RN Inhibition of phosphatidylinositol-specific phospholipase C by phosphonate substrate analogues. Biochim Biophys Acta. 1990 Feb 23;1042(3):410-2. DMAJ9ZD RU https://pubmed.ncbi.nlm.nih.gov/2106349 DM63OD7 DI DM63OD7 DM63OD7 DN Pifithrin-alpha DM63OD7 MI TT7SBF5 DM63OD7 MN Cellular tumor antigen p53 (TP53) DM63OD7 MT DTT DM63OD7 MA Inhibitor DM63OD7 RN An evaluation of the ability of pifithrin-alpha and -beta to inhibit p53 function in two wild-type p53 human tumor cell lines. Mol Cancer Ther. 2005 Sep;4(9):1369-77. DM63OD7 RU https://pubmed.ncbi.nlm.nih.gov/16170029 DMR87MO DI DMR87MO DMR87MO DN PIROXANTRONE DMR87MO MI TTGTQHC DMR87MO MN DNA topoisomerase I (TOP1) DMR87MO MT DTT DMR87MO MA Modulator DMR87MO RN The displacement of iron(III) from its complexes with the anticancer drugs piroxantrone and losoxantrone by the hydrolyzed form of the cardioprotec... J Inorg Biochem. 1999 Nov-Dec;77(3-4):257-9. DMR87MO RU https://www.ncbi.nlm.nih.gov/pubmed/10643663 DMPHUBO DI DMPHUBO DMPHUBO DN PLD-177 DMPHUBO MI TTPNQAC DMPHUBO MN Estrogen-related receptor-alpha (ESRRA) DMPHUBO MT DTT DMPHUBO MA Modulator DMPHUBO RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 622). DMPHUBO RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=622 DMT83V6 DI DMT83V6 DMT83V6 DN PNQX DMT83V6 MI TTAN6JD DMT83V6 MN Glutamate receptor AMPA (GRIA) DMT83V6 MT DTT DMT83V6 MA Antagonist DMT83V6 RN Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800005697) DMT83V6 RU http://adisinsight.springer.com/drugs/800005697 DMZNM2K DI DMZNM2K DMZNM2K DN PNU-109291 DMZNM2K MI TT6MSOK DMZNM2K MN 5-HT 1D receptor (HTR1D) DMZNM2K MT DTT DMZNM2K MA Agonist DMZNM2K RN Role of 5-HT(1) receptor subtypes in the modulation of pain and synaptic transmission in rat spinal superficial dorsal horn. Br J Pharmacol. 2012 Mar;165(6):1956-65. DMZNM2K RU https://pubmed.ncbi.nlm.nih.gov/21950560 DM23ZHN DI DM23ZHN DM23ZHN DN PNU156804 DM23ZHN MI TTT7PJU DM23ZHN MN Janus kinase 3 (JAK-3) DM23ZHN MT DTT DM23ZHN MA Inhibitor DM23ZHN RN Selective inhibitor of Janus tyrosine kinase 3, PNU156804, prolongs allograft survival and acts synergistically with cyclosporine but additively with rapamycin. Blood. 2002 Jan 15;99(2):680-9. DM23ZHN RU https://pubmed.ncbi.nlm.nih.gov/11781254 DMRT69H DI DMRT69H DMRT69H DN PNU-177864 DMRT69H MI TT4C8EA DMRT69H MN Dopamine D3 receptor (D3R) DMRT69H MT DTT DMRT69H MA Antagonist DMRT69H RN The pipeline and future of drug development in schizophrenia. Mol Psychiatry. 2007 Oct;12(10):904-22. DMRT69H RU https://pubmed.ncbi.nlm.nih.gov/17667958 DMGDC36 DI DMGDC36 DMGDC36 DN PNU-282987 DMGDC36 MI TTLA931 DMGDC36 MN Neuronal acetylcholine receptor alpha-7 (CHRNA7) DMGDC36 MT DTT DMGDC36 MA Antagonist DMGDC36 RN The pipeline and future of drug development in schizophrenia. Mol Psychiatry. 2007 Oct;12(10):904-22. DMGDC36 RU https://pubmed.ncbi.nlm.nih.gov/17667958 DMGDC36 DI DMGDC36 DMGDC36 DN PNU-282987 DMGDC36 MI TTC97NF DMGDC36 MN TNFA messenger RNA (TNF mRNA) DMGDC36 MT DTT DMGDC36 RN Antisense oligonucleotide blockade of tumor necrosis factor-alpha in two murine models of colitis. J Pharmacol Exp Ther. 2003 Jan;304(1):411-24. DMGDC36 RU https://pubmed.ncbi.nlm.nih.gov/12490618 DMLMISK DI DMLMISK DMLMISK DN PNU-96391A DMLMISK MI TTEX248 DMLMISK MN Dopamine D2 receptor (D2R) DMLMISK MT DTT DMLMISK MA Modulator DMLMISK RN The dopamine stabilizer (-)-OSU6162 occupies a subpopulation of striatal dopamine D2/D3 receptors: an [(11)C]raclopride PET study in healthy human subjects. Neuropsychopharmacology. 2015 Jan;40(2):472-9. DMLMISK RU https://pubmed.ncbi.nlm.nih.gov/25248987 DMLMISK DI DMLMISK DMLMISK DN PNU-96391A DMLMISK MI TT4C8EA DMLMISK MN Dopamine D3 receptor (D3R) DMLMISK MT DTT DMLMISK MA Modulator DMLMISK RN The dopamine stabilizer (-)-OSU6162 occupies a subpopulation of striatal dopamine D2/D3 receptors: an [(11)C]raclopride PET study in healthy human subjects. Neuropsychopharmacology. 2015 Jan;40(2):472-9. DMLMISK RU https://pubmed.ncbi.nlm.nih.gov/25248987 DMLY2TN DI DMLY2TN DMLY2TN DN PPACK DMLY2TN MI TT6L509 DMLY2TN MN Coagulation factor IIa (F2) DMLY2TN MT DTT DMLY2TN MA Inhibitor DMLY2TN RN Anticoagulation: the present and future. Clin Appl Thromb Hemost. 2001 Jul;7(3):195-204. DMLY2TN RU https://pubmed.ncbi.nlm.nih.gov/11441979 DMI2N9H DI DMI2N9H DMI2N9H DN Pranidipine DMI2N9H MI TT5HONZ DMI2N9H MN Calcium channel unspecific (CaC) DMI2N9H MT DTT DMI2N9H MA Modulator DMI2N9H RN Pranidipine, a new 1,4-dihydropyridine calcium channel blocker, enhances cyclic GMP-independent nitric oxide-induced relaxation of the rat aorta. Mol Cell Biochem. 1998 Jan;178(1-2):335-43. DMI2N9H RU https://pubmed.ncbi.nlm.nih.gov/9546618 DMDIYFH DI DMDIYFH DMDIYFH DN PRE-084 DMDIYFH MI TT5TPI6 DMDIYFH MN Opioid receptor sigma 1 (OPRS1) DMDIYFH MT DTT DMDIYFH MA Modulator DMDIYFH RN Antidepressant-like effect of PRE-084, a selective sigma1 receptor agonist, in Albino Swiss and C57BL/6J mice. Pharmacol Rep. 2009 Nov-Dec;61(6):1179-83. DMDIYFH RU https://pubmed.ncbi.nlm.nih.gov/20081254 DMS4FG0 DI DMS4FG0 DMS4FG0 DN Promegapoietin DMS4FG0 MI TTIHYA4 DMS4FG0 MN Thrombopoietin receptor (MPL) DMS4FG0 MT DTT DMS4FG0 MA Modulator DMS4FG0 RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. DMS4FG0 RU https://www.fda.gov/ DM57YO8 DI DM57YO8 DM57YO8 DN Protosufloxacin DM57YO8 MI TTN6J5F DM57YO8 MN Bacterial DNA gyrase (Bact gyrase) DM57YO8 MT DTT DM57YO8 MA Modulator DM57YO8 RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. DM57YO8 RU https://www.fda.gov/ DMNK2I0 DI DMNK2I0 DMNK2I0 DN PRS-639058 DMNK2I0 MI TTMSFAW DMNK2I0 MN Cannabinoid receptor 2 (CB2) DMNK2I0 MT DTT DMNK2I0 MA Agonist DMNK2I0 RN Targeting CB2 receptors and the endocannabinoid system for the treatment of pain. Brain Res Rev. 2009 April; 60(1): 255-266. DMNK2I0 RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4549801/ DM8P05S DI DM8P05S DM8P05S DN PS-388023 DM8P05S MI TT69TQN DM8P05S MN Integrin alpha-V/beta-3 (ITGAV/B3) DM8P05S MT DTT DM8P05S MA Modulator DM8P05S RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. DM8P05S RU https://www.fda.gov/ DM8P05S DI DM8P05S DM8P05S DN PS-388023 DM8P05S MI TTPRDH7 DM8P05S MN Integrin alpha-V/beta-5 (ITGAV/B5) DM8P05S MT DTT DM8P05S MA Modulator DM8P05S RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. DM8P05S RU https://www.fda.gov/ DMI0WHC DI DMI0WHC DMI0WHC DN PS-519 DMI0WHC MI TTU7ZMG DMI0WHC MN Proteasome (PS) DMI0WHC MT DTT DMI0WHC MA Modulator DMI0WHC RN Effect of the proteasome inhibitor MLN519 on the expression of inflammatory molecules following middle cerebral artery occlusion and reperfusion in... Neurotox Res. 2003;5(7):505-14. DMI0WHC RU https://www.ncbi.nlm.nih.gov/pubmed/14715434 DMWUOA8 DI DMWUOA8 DMWUOA8 DN PSI-6130 DMWUOA8 MI TTMVBWH DMWUOA8 MN Hepatitis C virus RNA-directed RNA polymerase (HCV NS5B) DMWUOA8 MT DTT DMWUOA8 MA Inhibitor DMWUOA8 RN An efficient and diastereoselective synthesis of PSI-6130: a clinically efficacious inhibitor of HCV NS5B polymerase. J Org Chem. 2009 Sep 4;74(17):6819-24. DMWUOA8 RU https://pubmed.ncbi.nlm.nih.gov/19642660 DM579WS DI DM579WS DM579WS DN PSI-661 DM579WS MI TTMVBWH DM579WS MN Hepatitis C virus RNA-directed RNA polymerase (HCV NS5B) DM579WS MT DTT DM579WS MA Modulator DM579WS RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. DM579WS RU https://www.fda.gov/ DMGEWUS DI DMGEWUS DMGEWUS DN PSN821 DMGEWUS MI TT7QNVC DMGEWUS MN Glucose-dependent insulinotropic receptor (GPR119) DMGEWUS MT DTT DMGEWUS MA Agonist DMGEWUS RN Clinical pipeline report, company report or official report of Astellas Pharma (2011). DMGEWUS RU http://www.astellas.com/en/ DMH3RPO DI DMH3RPO DMH3RPO DN PT-630 DMH3RPO MI TTDIGC1 DMH3RPO MN Dipeptidyl peptidase 4 (DPP-4) DMH3RPO MT DTT DMH3RPO MA Modulator DMH3RPO RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. DMH3RPO RU https://www.fda.gov/ DM89RT7 DI DM89RT7 DM89RT7 DN PTX-007011 DM89RT7 MI TT4YO0Z DM89RT7 MN Phosphopantetheine adenylyltransferase (PPAT) DM89RT7 MT DTT DM89RT7 MA Inhibitor DM89RT7 RN NME DIGEST. Drug News & Perspect 2002, 15(8):519, ISSN 0214-0934. DM89RT7 RU https://journals.prous.com/journals/servlet/xmlxsl/pk_journals.xml_summary_pr?p_JournalId=3&p_RefId=695454&p_IsPs=N DM84RHP DI DM84RHP DM84RHP DN PTX-008313 DM84RHP MI TTQAOZR DM84RHP MN Bacterial Chorismate synthase (Bact aroC) DM84RHP MT DTT DM84RHP MA Inhibitor DM84RHP RN US patent application no. 2009,0048,155, Methods for preventing and treating tissue injury and sepsis associated with yersinia pestis infection. DM84RHP RU http://www.google.com/patents/US20090048155 DM63O4F DI DM63O4F DM63O4F DN PURPUROGALLIN DM63O4F MI TTRE6AX DM63O4F MN Bcl-x messenger RNA (BCL2L1 mRNA) DM63O4F MT DTT DM63O4F MA Inhibitor DM63O4F RN Discovery, characterization, and structure-activity relationships studies of proapoptotic polyphenols targeting B-cell lymphocyte/leukemia-2 proteins. J Med Chem. 2003 Sep 25;46(20):4259-64. DM63O4F RU https://pubmed.ncbi.nlm.nih.gov/13678404 DM63O4F DI DM63O4F DM63O4F DN PURPUROGALLIN DM63O4F MI TT2IYXF DM63O4F MN L-selectin (SELL) DM63O4F MT DTT DM63O4F MA Inhibitor DM63O4F RN Rational design of novel, potent small molecule pan-selectin antagonists. J Med Chem. 2007 Mar 22;50(6):1101-15. DM63O4F RU https://pubmed.ncbi.nlm.nih.gov/17302397 DM63O4F DI DM63O4F DM63O4F DN PURPUROGALLIN DM63O4F MI TTE5VG0 DM63O4F MN P-selectin (SELP) DM63O4F MT DTT DM63O4F MA Inhibitor DM63O4F RN Rational design of novel, potent small molecule pan-selectin antagonists. J Med Chem. 2007 Mar 22;50(6):1101-15. DM63O4F RU https://pubmed.ncbi.nlm.nih.gov/17302397 DMCNE2G DI DMCNE2G DMCNE2G DN PX-867 DMCNE2G MI TTHBTOP DMCNE2G MN PI3-kinase gamma (PIK3CG) DMCNE2G MT DTT DMCNE2G MA Modulator DMCNE2G RN Pharmacologic profiling of phosphoinositide 3-kinase inhibitors as mitigators of ionizing radiation-induced cell death. J Pharmacol Exp Ther. 2013 Dec;347(3):669-80. DMCNE2G RU https://pubmed.ncbi.nlm.nih.gov/24068833 DM1AXZ6 DI DM1AXZ6 DM1AXZ6 DN PXS-2076 DM1AXZ6 MI TTMSFAW DM1AXZ6 MN Cannabinoid receptor 2 (CB2) DM1AXZ6 MT DTT DM1AXZ6 MA Agonist DM1AXZ6 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 57). DM1AXZ6 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=57 DM8RHST DI DM8RHST DM8RHST DN QAP-642 DM8RHST MI TTD3XFU DM8RHST MN C-C chemokine receptor type 3 (CCR3) DM8RHST MT DTT DM8RHST MA Antagonist DM8RHST RN New Drugs and Targets for Asthma and COPD. T.T. Hansel, P.J. Barnes. 2010. Page 158. DM8RHST RU https://books.google.com.hk/books?id=-Zg7AQAAQBAJ&pg=PT172&lpg=PT172&dq=QAP-642++CCR3&source=bl&ots=mTJNnzpSCz&sig=TbtUMK5VhyKIqvrzRk-gWt9mjqk&hl=zh-CN&sa=X&ved=0CCEQ6AEwAWoVChMIjYeezrbGyAIVChuOCh1s3QSC#v=onepage&q=QAP-642%20%20CCR3&f=false DMAV2FM DI DMAV2FM DMAV2FM DN QX-314 DMAV2FM MI TTN9VTF DMAV2FM MN Voltage-gated sodium channel alpha Nav1.9 (SCN11A) DMAV2FM MT DTT DMAV2FM MA Blocker DMAV2FM RN Voltage-gated sodium channel blockers for the treatment of chronic pain. Curr Top Med Chem. 2009;9(4):362-76. DMAV2FM RU https://pubmed.ncbi.nlm.nih.gov/19442207 DMA187T DI DMA187T DMA187T DN R zileuton DMA187T MI TT2J34L DMA187T MN Arachidonate 5-lipoxygenase (5-LOX) DMA187T MT DTT DMA187T MA Inhibitor DMA187T RN Mechanism-based inhibition of human liver microsomal cytochrome P450 1A2 by zileuton, a 5-lipoxygenase inhibitor. Drug Metab Dispos. 2003 Nov;31(11):1352-60. DMA187T RU https://pubmed.ncbi.nlm.nih.gov/14570767 DM46YHG DI DM46YHG DM46YHG DN R-102444 DM46YHG MI TTJQOD7 DM46YHG MN 5-HT 2A receptor (HTR2A) DM46YHG MT DTT DM46YHG MA Modulator DM46YHG RN Effects of R-102444 and its active metabolite R-96544, selective 5-HT2A receptor antagonists, on experimental acute and chronic pancreatitis: Additional evidence for possible involvement of 5-HT2A receptors in the development of experimental pancreatitis.Eur J Pharmacol.2005 Oct 3;521(1-3):156-63. DM46YHG RU https://www.ncbi.nlm.nih.gov/pubmed/16183055 DMIBCZ5 DI DMIBCZ5 DMIBCZ5 DN R-1315 DMIBCZ5 MI TTXEU7H DMIBCZ5 MN GPCR unspecific (GPCR) DMIBCZ5 MT DTT DMIBCZ5 MA Modulator DMIBCZ5 RN Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800017252) DMIBCZ5 RU http://adisinsight.springer.com/drugs/800017252 DMBU24I DI DMBU24I DMBU24I DN R-1437 DMBU24I MI TTXEU7H DMBU24I MN GPCR unspecific (GPCR) DMBU24I MT DTT DMBU24I MA Antagonist DMBU24I RN Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800017122) DMBU24I RU http://adisinsight.springer.com/drugs/800017122 DM8XBKG DI DM8XBKG DM8XBKG DN R-1554 DM8XBKG MI TTXEU7H DM8XBKG MN GPCR unspecific (GPCR) DM8XBKG MT DTT DM8XBKG MA Antagonist DM8XBKG RN Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800018539) DM8XBKG RU http://adisinsight.springer.com/drugs/800018539 DM12EYR DI DM12EYR DM12EYR DN R348 DM12EYR MI TTT7PJU DM12EYR MN Janus kinase 3 (JAK-3) DM12EYR MT DTT DM12EYR MA Inhibitor DM12EYR RN Emerging drugs for psoriasis. Expert Opin Emerg Drugs. 2009 Mar;14(1):145-63. DM12EYR RU https://pubmed.ncbi.nlm.nih.gov/19249988 DMYTI3J DI DMYTI3J DMYTI3J DN R-56865 DMYTI3J MI TTZIFHC DMYTI3J MN Voltage-gated calcium channel alpha Cav1.2 (CACNA1C) DMYTI3J MT DTT DMYTI3J MA Inhibitor DMYTI3J RN Novel calcium antagonists with both calcium overload inhibition and antioxidant activity. 1. 2-(3, 5-di-tert-butyl-4-hydroxyphenyl)-3-(aminopropyl)... J Med Chem. 1998 Oct 22;41(22):4309-16. DMYTI3J RU https://pubmed.ncbi.nlm.nih.gov/9784106 DM36JFP DI DM36JFP DM36JFP DN R-59494 DM36JFP MI TTRK8B9 DM36JFP MN Sodium channel unspecific (NaC) DM36JFP MT DTT DM36JFP MA Modulator DM36JFP RN Veratridine activates a silent sodium channel in rat isolated aorta. Eur J Pharmacol. 1992 Aug 25;219(2):253-9. DM36JFP RU https://pubmed.ncbi.nlm.nih.gov/1330608 DMLAIZG DI DMLAIZG DMLAIZG DN R-7025 DMLAIZG MI TT95SOA DMLAIZG MN Interferon alpha (IFNA) DMLAIZG MT DTT DMLAIZG MA Modulator DMLAIZG RN WO patent application no. 2013,0667,53, Compositions useful for the treatment of viral diseases. DMLAIZG RU http://worldwide.espacenet.com/publicationDetails/biblio?DB=worldwide.espacenet.com&II=0&ND=3&adjacent=true&locale=en_EP&FT=D&date=20130510&CC=WO&NR=2013066753A1&KC=A1 DMZQJVN DI DMZQJVN DMZQJVN DN R-85355 DMZQJVN MI TT2J34L DMZQJVN MN Arachidonate 5-lipoxygenase (5-LOX) DMZQJVN MT DTT DMZQJVN MA Inhibitor DMZQJVN RN Topical R-85355, a potent and selective 5-lipoxygenase inhibitor, fails to improve psoriasis. Skin Pharmacol. 1996;9(5):307-11. DMZQJVN RU https://pubmed.ncbi.nlm.nih.gov/8990505 DM7HAE9 DI DM7HAE9 DM7HAE9 DN Ralitoline DM7HAE9 MI TTRK8B9 DM7HAE9 MN Sodium channel unspecific (NaC) DM7HAE9 MT DTT DM7HAE9 MA Modulator DM7HAE9 RN Anticonvulsant and sodium channel blocking effects of ralitoline in different screening models. Naunyn Schmiedebergs Arch Pharmacol. 1992 Oct;346(4):442-52. DM7HAE9 RU https://pubmed.ncbi.nlm.nih.gov/1331817 DM4FNWO DI DM4FNWO DM4FNWO DN RC-01 DM4FNWO MI TT0OFWN DM4FNWO MN Pseudomonas UDP-3-O-acyl-GlcNAc deacetylase (Pseudo lpxC) DM4FNWO MT DTT DM4FNWO MA Inhibitor DM4FNWO RN The global preclinical antibacterial pipeline. Nat Rev Microbiol. 2020 May;18(5):275-285. DM4FNWO RU https://pubmed.ncbi.nlm.nih.gov/31745331 DM08BUV DI DM08BUV DM08BUV DN RDEA-427 DM08BUV MI TT84ETX DM08BUV MN Human immunodeficiency virus Reverse transcriptase (HIV RT) DM08BUV MT DTT DM08BUV MA Inhibitor DM08BUV RN CN patent application no. 103360398, Triazolopyrimidine hiv-1 retrovirus inhibitor and its preparation method and application thereof. DM08BUV RU http://www.google.com/patents/CN103360398A?cl=en DM61RGQ DI DM61RGQ DM61RGQ DN RDEA-640 DM61RGQ MI TT84ETX DM61RGQ MN Human immunodeficiency virus Reverse transcriptase (HIV RT) DM61RGQ MT DTT DM61RGQ MA Inhibitor DM61RGQ RN WO patent application no. 2008,0165,22, Novel hiv reverse transcriptase inhibitors. DM61RGQ RU http://worldwide.espacenet.com/publicationDetails/biblio?DB=worldwide.espacenet.com&II=0&ND=3&adjacent=true&locale=en_EP&FT=D&date=20080207&CC=WO&NR=2008016522A2&KC=A2 DMDC2E8 DI DMDC2E8 DMDC2E8 DN Recainam DMDC2E8 MI TTRK8B9 DMDC2E8 MN Sodium channel unspecific (NaC) DMDC2E8 MT DTT DMDC2E8 MA Modulator DMDC2E8 RN Effects of renal function on recainam pharmacokinetics and pharmacodynamics. Clin Pharmacol Ther. 1995 May;57(5):492-8. DMDC2E8 RU https://pubmed.ncbi.nlm.nih.gov/7768071 DMWIAUK DI DMWIAUK DMWIAUK DN ReN-1820 DMWIAUK MI TTEDJN4 DMWIAUK MN Low-affinity nerve growth factor receptor (NGFR) DMWIAUK MT DTT DMWIAUK MA Inhibitor DMWIAUK RN Phosphorylation of Extracellular Signal-Regulated Kinases (pERK1/2) in Bladder Afferent Pathways with Cyclophosphamide (CYP)-Induced Cystitis. Neuroscience. 2009 November 10; 163(4): 1353-1362. DMWIAUK RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2760658/ DMGY51F DI DMGY51F DMGY51F DN ReN-1826 DMGY51F MI TTZHKV9 DMGY51F MN Neurotrophin-3 (NTF3) DMGY51F MT DTT DMGY51F MA Inhibitor DMGY51F RN Pulmonary distribution, regulation, and functional role of Trk receptors in a murine model of asthma. J Allergy Clin Immunol. 2006 Sep;118(3):597-605. DMGY51F RU https://pubmed.ncbi.nlm.nih.gov/16950277 DMGY51F DI DMGY51F DMGY51F DN ReN-1826 DMGY51F MI TTIM2WO DMGY51F MN Neurotrophin-4 (NTF4) DMGY51F MT DTT DMGY51F MA Inhibitor DMGY51F RN Pulmonary distribution, regulation, and functional role of Trk receptors in a murine model of asthma. J Allergy Clin Immunol. 2006 Sep;118(3):597-605. DMGY51F RU https://pubmed.ncbi.nlm.nih.gov/16950277 DM1XYJU DI DM1XYJU DM1XYJU DN RES-701-1 DM1XYJU MI TT3ZTGU DM1XYJU MN Endothelin B receptor (EDNRB) DM1XYJU MT DTT DM1XYJU MA Inhibitor DM1XYJU RN RES-701-1/endothelin-1 hybrid peptide having a potent binding activity for type B receptor, Bioorg. Med. Chem. Lett. 7(13):1715-1720 (1997). DM1XYJU RU http://www.sciencedirect.com/science/article/pii/S0960894X97002965 DMI94L1 DI DMI94L1 DMI94L1 DN REV-5901 DMI94L1 MI TT2J34L DMI94L1 MN Arachidonate 5-lipoxygenase (5-LOX) DMI94L1 MT DTT DMI94L1 MA Inhibitor DMI94L1 RN Indazolinones, a new series of redox-active 5-lipoxygenase inhibitors with built-in selectivity and oral activity. J Med Chem. 1991 Mar;34(3):1028-36. DMI94L1 RU https://pubmed.ncbi.nlm.nih.gov/1848292 DM314CZ DI DM314CZ DM314CZ DN REV-598 DM314CZ MI TT85JO3 DM314CZ MN 5-HT receptor (5HTR) DM314CZ MT DTT DM314CZ MA Inhibitor DM314CZ RN Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800016819) DM314CZ RU http://adisinsight.springer.com/drugs/800016819 DM314CZ DI DM314CZ DM314CZ DN REV-598 DM314CZ MI TT7CXIM DM314CZ MN Histamine receptor (HR) DM314CZ MT DTT DM314CZ MA Inhibitor DM314CZ RN Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800016819) DM314CZ RU http://adisinsight.springer.com/drugs/800016819 DMA971L DI DMA971L DMA971L DN Reveromycin A DMA971L MI TT6KYJ5 DMA971L MN Bacterial Isoleucyl-tRNA synthetase (Bact ileS) DMA971L MT DTT DMA971L MA Inhibitor DMA971L RN Chemical modification of reveromycin A and its biological activities. Bioorg Med Chem Lett. 2002 Dec 2;12(23):3363-6. DMA971L RU https://pubmed.ncbi.nlm.nih.gov/12419362 DMA971L DI DMA971L DMA971L DN Reveromycin A DMA971L MI TTYD3AN DMA971L MN Isoleucyl-tRNA synthetase (IARS) DMA971L MT DTT DMA971L MA Inhibitor DMA971L RN Synthesis and biological activities of reveromycin A and spirofungin A derivatives. Bioorg Med Chem Lett. 2008 Jul 1;18(13):3756-60. DMA971L RU https://pubmed.ncbi.nlm.nih.gov/18519164 DMRFYOS DI DMRFYOS DMRFYOS DN RG-13022 DMRFYOS MI TT8FYO9 DMRFYOS MN Platelet-derived growth factor receptor alpha (PDGFRA) DMRFYOS MT DTT DMRFYOS MA Inhibitor DMRFYOS RN A new series of PDGF receptor tyrosine kinase inhibitors: 3-substituted quinoline derivatives. J Med Chem. 1994 Jul 8;37(14):2129-37. DMRFYOS RU https://pubmed.ncbi.nlm.nih.gov/8035419 DMRFYOS DI DMRFYOS DMRFYOS DN RG-13022 DMRFYOS MI TTI7421 DMRFYOS MN Platelet-derived growth factor receptor beta (PDGFRB) DMRFYOS MT DTT DMRFYOS MA Inhibitor DMRFYOS RN A new series of PDGF receptor tyrosine kinase inhibitors: 3-substituted quinoline derivatives. J Med Chem. 1994 Jul 8;37(14):2129-37. DMRFYOS RU https://pubmed.ncbi.nlm.nih.gov/8035419 DMKFQC7 DI DMKFQC7 DMKFQC7 DN RG-14893 DMKFQC7 MI TTN53ZF DMKFQC7 MN Leukotriene B4 receptor 1 (LTB4R) DMKFQC7 MT DTT DMKFQC7 MA Modulator DMKFQC7 RN Structure-activity relationships study of two series of leukotriene B4 antagonists: novel indolyl and naphthyl compounds substituted with a 2-[methyl(2-phenethyl)amino]-2-oxoethyl side chain. J Med Chem. 1996 Sep 13;39(19):3756-68. DMKFQC7 RU https://pubmed.ncbi.nlm.nih.gov/8809164 DMI0CYV DI DMI0CYV DMI0CYV DN RG-8803 DMI0CYV MI TTGKIED DMI0CYV MN Fibroblast growth factor-2 (FGF2) DMI0CYV MT DTT DMI0CYV MA Inhibitor DMI0CYV RN US patent application no. 2010,0278,784, Methods and compositions for treating skin conditions. DMI0CYV RU https://www.google.com.ar/patents/US20100278784 DMI0CYV DI DMI0CYV DMI0CYV DN RG-8803 DMI0CYV MI TTVJ1D8 DMI0CYV MN Vascular endothelial growth factor receptor (VEGFR) DMI0CYV MT DTT DMI0CYV MA Inhibitor DMI0CYV RN US patent application no. 2010,0278,784, Methods and compositions for treating skin conditions. DMI0CYV RU https://www.google.com.ar/patents/US20100278784 DM8RIA6 DI DM8RIA6 DM8RIA6 DN RGH-1756 DM8RIA6 MI TT4C8EA DM8RIA6 MN Dopamine D3 receptor (D3R) DM8RIA6 MT DTT DM8RIA6 MA Antagonist DM8RIA6 RN The pipeline and future of drug development in schizophrenia. Mol Psychiatry. 2007 Oct;12(10):904-22. DM8RIA6 RU https://pubmed.ncbi.nlm.nih.gov/17667958 DMBCIPO DI DMBCIPO DMBCIPO DN RGH-2721 DMBCIPO MI TT85JO3 DMBCIPO MN 5-HT receptor (5HTR) DMBCIPO MT DTT DMBCIPO MA Modulator DMBCIPO RN Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800004008) DMBCIPO RU http://adisinsight.springer.com/drugs/800004008 DM7CY0T DI DM7CY0T DM7CY0T DN RHb1.1 DM7CY0T MI TTQO71U DM7CY0T MN Hemoglobin (HB) DM7CY0T MT DTT DM7CY0T MA Modulator DM7CY0T RN Effects of recombinant-hemoglobin solutions rHb2.0 and rHb1.1 on blood pressure, intestinal blood flow, and gut oxygenation in a rat model of hemorrhagic shock. J Lab Clin Med. 2005 Jan;145(1):21-32. DM7CY0T RU https://pubmed.ncbi.nlm.nih.gov/15668658 DMW4UTB DI DMW4UTB DMW4UTB DN RhuCD40L DMW4UTB MI TTN6Y9A DMW4UTB MN CD40L receptor (CD40) DMW4UTB MT DTT DMW4UTB MA Binder DMW4UTB RN Recombinant CD40 ligand therapy has significant antitumor effects on CD40-positive ovarian tumor xenografts grown in SCID mice and demonstrates an augmented effect with cisplatin. Cancer Res. 2001 Oct 15;61(20):7556-62. DMW4UTB RU https://pubmed.ncbi.nlm.nih.gov/11606394 DMKDS1C DI DMKDS1C DMKDS1C DN Rimcazole DMKDS1C MI TT5TPI6 DMKDS1C MN Opioid receptor sigma 1 (OPRS1) DMKDS1C MT DTT DMKDS1C MA Antagonist DMKDS1C RN The pipeline and future of drug development in schizophrenia. Mol Psychiatry. 2007 Oct;12(10):904-22. DMKDS1C RU https://pubmed.ncbi.nlm.nih.gov/17667958 DMHQ5ZE DI DMHQ5ZE DMHQ5ZE DN RN-1005 DMHQ5ZE MI TTVZ87F DMHQ5ZE MN Wnt protein (WNT) DMHQ5ZE MT DTT DMHQ5ZE MA Modulator DMHQ5ZE RN Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800033803) DMHQ5ZE RU http://adisinsight.springer.com/drugs/800033803 DM0PSCF DI DM0PSCF DM0PSCF DN Ro 20-1724 DM0PSCF MI TTLZS4Q DM0PSCF MN M-phase inducer phosphatase 1 (MPIP1) DM0PSCF MT DTT DM0PSCF MA Inhibitor DM0PSCF RN Role of the Cdc25A phosphatase in human breast cancer. J Clin Invest. 2000 Sep;106(6):753-61. DM0PSCF RU https://pubmed.ncbi.nlm.nih.gov/10995786 DM0PSCF DI DM0PSCF DM0PSCF DN Ro 20-1724 DM0PSCF MI TTV5CGO DM0PSCF MN Phosphodiesterase 4 (PDE4) DM0PSCF MT DTT DM0PSCF MA Inhibitor DM0PSCF RN Increased interleukin-4 production by atopic mononuclear leukocytes correlates with increased cyclic adenosine monophosphate-phosphodiesterase activity and is reversible by phosphodiesterase inhibition. J Invest Dermatol. 1993 May;100(5):681-4. DM0PSCF RU https://pubmed.ncbi.nlm.nih.gov/8388009 DMFRCM2 DI DMFRCM2 DMFRCM2 DN Ro-19-8022 DMFRCM2 MI TTEX6LM DMFRCM2 MN GABA(A) receptor gamma-3 (GABRG3) DMFRCM2 MT DTT DMFRCM2 MA Modulator DMFRCM2 RN Partial agonist of benzodiazepine receptors Ro 19-8022 elicits withdrawal symptoms after short-term administration in immature rats. Physiol Res. 2012;61(3):319-23. DMFRCM2 RU https://www.ncbi.nlm.nih.gov/pubmed/22816377 DM7B2WH DI DM7B2WH DM7B2WH DN Ro-23-7777 DM7B2WH MI TTN6J5F DM7B2WH MN Bacterial DNA gyrase (Bact gyrase) DM7B2WH MT DTT DM7B2WH MA Modulator DM7B2WH RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. DM7B2WH RU https://www.fda.gov/ DMJQA0D DI DMJQA0D DMJQA0D DN Ro-24-0238 DMJQA0D MI TTQL5VC DMJQA0D MN Platelet-activating factor receptor (PTAFR) DMJQA0D MT DTT DMJQA0D MA Inhibitor DMJQA0D RN Pentadienyl carboxamide derivatives as antagonists of platelet-activating factor. J Med Chem. 1989 Aug;32(8):1820-35. DMJQA0D RU https://pubmed.ncbi.nlm.nih.gov/2754709 DMVB0C3 DI DMVB0C3 DMVB0C3 DN Ro-25-4094 DMVB0C3 MI TTN53ZF DMVB0C3 MN Leukotriene B4 receptor 1 (LTB4R) DMVB0C3 MT DTT DMVB0C3 MA Modulator DMVB0C3 RN Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800005401) DMVB0C3 RU http://adisinsight.springer.com/drugs/800005401 DM07ZSC DI DM07ZSC DM07ZSC DN Ro-25-6833 DM07ZSC MI TTXT4D5 DM07ZSC MN Bacterial Cell membrane (Bact CM) DM07ZSC MT DTT DM07ZSC MA Modulator DM07ZSC RN Animal pharmacokinetics and interspecies scaling of Ro 25-6833 and related (lactamylvinyl)cephalosporins. J Pharm Sci. 1998 Apr;87(4):496-500. DM07ZSC RU https://pubmed.ncbi.nlm.nih.gov/9548904 DM3H921 DI DM3H921 DM3H921 DN RO-25-6981 DM3H921 MI TTN9D8E DM3H921 MN Glutamate receptor ionotropic NMDA 2B (NMDAR2B) DM3H921 MT DTT DM3H921 MA Antagonist DM3H921 RN Emerging analgesics in cancer pain management. Expert Opin Emerg Drugs. 2005 Feb;10(1):151-71. DM3H921 RU https://pubmed.ncbi.nlm.nih.gov/15757410 DM8B9YT DI DM8B9YT DM8B9YT DN Ro-31-4724 DM8B9YT MI TTMX39J DM8B9YT MN Matrix metalloproteinase-1 (MMP-1) DM8B9YT MT DTT DM8B9YT MA Inhibitor DM8B9YT RN Receptor flexibility in the in silico screening of reagents in the S1' pocket of human collagenase. J Med Chem. 2004 May 20;47(11):2761-7. DM8B9YT RU https://pubmed.ncbi.nlm.nih.gov/15139754 DMTIW6K DI DMTIW6K DMTIW6K DN Ro-31-8830 DMTIW6K MI TTYVX59 DMTIW6K MN Protein kinase C (PRKC) DMTIW6K MT DTT DMTIW6K MA Inhibitor DMTIW6K RN Oral, anti-inflammatory activity of a potent, selective, protein kinase C inhibitor. Agents Actions. 1992 Sep;37(1-2):85-9. DMTIW6K RU https://pubmed.ncbi.nlm.nih.gov/1456183 DML3NEU DI DML3NEU DML3NEU DN RO-319790 DML3NEU MI TTMX39J DML3NEU MN Matrix metalloproteinase-1 (MMP-1) DML3NEU MT DTT DML3NEU MA Inhibitor DML3NEU RN The asymmetric synthesis and in vitro characterization of succinyl mercaptoalcohol and mercaptoketone inhibitors of matrix metalloproteinases. Bioorg Med Chem Lett. 1998 May 19;8(10):1163-8. DML3NEU RU https://pubmed.ncbi.nlm.nih.gov/9871728 DML3NEU DI DML3NEU DML3NEU DN RO-319790 DML3NEU MI TTUZ2L5 DML3NEU MN Matrix metalloproteinase-3 (MMP-3) DML3NEU MT DTT DML3NEU MA Inhibitor DML3NEU RN The asymmetric synthesis and in vitro characterization of succinyl mercaptoalcohol and mercaptoketone inhibitors of matrix metalloproteinases. Bioorg Med Chem Lett. 1998 May 19;8(10):1163-8. DML3NEU RU https://pubmed.ncbi.nlm.nih.gov/9871728 DML3NEU DI DML3NEU DML3NEU DN RO-319790 DML3NEU MI TT6X50U DML3NEU MN Matrix metalloproteinase-9 (MMP-9) DML3NEU MT DTT DML3NEU MA Inhibitor DML3NEU RN The asymmetric synthesis and in vitro characterization of succinyl mercaptoalcohol and mercaptoketone inhibitors of matrix metalloproteinases. Bioorg Med Chem Lett. 1998 May 19;8(10):1163-8. DML3NEU RU https://pubmed.ncbi.nlm.nih.gov/9871728 DMFZ1YW DI DMFZ1YW DMFZ1YW DN RO-320432 DMFZ1YW MI TTRSMW9 DMFZ1YW MN Glycogen synthase kinase-3 beta (GSK-3B) DMFZ1YW MT DTT DMFZ1YW MA Inhibitor DMFZ1YW RN Discovery of potent and bioavailable GSK-3beta inhibitors. Bioorg Med Chem Lett. 2010 Mar 1;20(5):1693-6. DMFZ1YW RU https://pubmed.ncbi.nlm.nih.gov/20138512 DMFZ1YW DI DMFZ1YW DMFZ1YW DN RO-320432 DMFZ1YW MI TTFJ8Q1 DMFZ1YW MN Protein kinase C alpha (PRKCA) DMFZ1YW MT DTT DMFZ1YW MA Inhibitor DMFZ1YW RN Bisindolylmaleimide inhibitors of protein kinase C. Further conformational restriction of a tertiary amine side chain, Bioorg. Med. Chem. Lett. 4(11):1303-1308 (1994). DMFZ1YW RU http://www.sciencedirect.com/science/article/pii/S0960894X01803498 DMFZ1YW DI DMFZ1YW DMFZ1YW DN RO-320432 DMFZ1YW MI TTYPXQF DMFZ1YW MN Protein kinase C beta (PRKCB) DMFZ1YW MT DTT DMFZ1YW MA Inhibitor DMFZ1YW RN Bisindolylmaleimide inhibitors of protein kinase C. Further conformational restriction of a tertiary amine side chain, Bioorg. Med. Chem. Lett. 4(11):1303-1308 (1994). DMFZ1YW RU http://www.sciencedirect.com/science/article/pii/S0960894X01803498 DMFZ1YW DI DMFZ1YW DMFZ1YW DN RO-320432 DMFZ1YW MI TT9WJ8U DMFZ1YW MN Protein kinase C delta (PRKCD) DMFZ1YW MT DTT DMFZ1YW MA Inhibitor DMFZ1YW RN Bisindolylmaleimide inhibitors of protein kinase C. Further conformational restriction of a tertiary amine side chain, Bioorg. Med. Chem. Lett. 4(11):1303-1308 (1994). DMFZ1YW RU http://www.sciencedirect.com/science/article/pii/S0960894X01803498 DMFZ1YW DI DMFZ1YW DMFZ1YW DN RO-320432 DMFZ1YW MI TTBZ7OD DMFZ1YW MN Protein kinase C epsilon (PRKCE) DMFZ1YW MT DTT DMFZ1YW MA Inhibitor DMFZ1YW RN Bisindolylmaleimide inhibitors of protein kinase C. Further conformational restriction of a tertiary amine side chain, Bioorg. Med. Chem. Lett. 4(11):1303-1308 (1994). DMFZ1YW RU http://www.sciencedirect.com/science/article/pii/S0960894X01803498 DMFZ1YW DI DMFZ1YW DMFZ1YW DN RO-320432 DMFZ1YW MI TTRFOXJ DMFZ1YW MN Protein kinase C gamma (PRKCG) DMFZ1YW MT DTT DMFZ1YW MA Inhibitor DMFZ1YW RN Bisindolylmaleimide inhibitors of protein kinase C. Further conformational restriction of a tertiary amine side chain, Bioorg. Med. Chem. Lett. 4(11):1303-1308 (1994). DMFZ1YW RU http://www.sciencedirect.com/science/article/pii/S0960894X01803498 DMFZ1YW DI DMFZ1YW DMFZ1YW DN RO-320432 DMFZ1YW MI TT8QL1J DMFZ1YW MN Protein kinase C theta (PRKCQ) DMFZ1YW MT DTT DMFZ1YW MA Inhibitor DMFZ1YW RN Bisindolylmaleimide inhibitors of protein kinase C. Further conformational restriction of a tertiary amine side chain, Bioorg. Med. Chem. Lett. 4(11):1303-1308 (1994). DMFZ1YW RU http://www.sciencedirect.com/science/article/pii/S0960894X01803498 DMFZ1YW DI DMFZ1YW DMFZ1YW DN RO-320432 DMFZ1YW MI TTUWGRA DMFZ1YW MN Protein kinase C zeta (PRKCZ) DMFZ1YW MT DTT DMFZ1YW MA Inhibitor DMFZ1YW RN Bisindolylmaleimide inhibitors of protein kinase C. Further conformational restriction of a tertiary amine side chain, Bioorg. Med. Chem. Lett. 4(11):1303-1308 (1994). DMFZ1YW RU http://www.sciencedirect.com/science/article/pii/S0960894X01803498 DMPNHF0 DI DMPNHF0 DMPNHF0 DN Ro-43-5054 DMPNHF0 MI TTJA1ZO DMPNHF0 MN ITGB3 messenger RNA (ITGB3 mRNA) DMPNHF0 MT DTT DMPNHF0 MA Inhibitor DMPNHF0 RN Platelet glycoprotein IIb-IIIa antagonists as prototypical integrin blockers: novel parenteral and potential oral antithrombotic agents. J Med Chem. 2000 Sep 21;43(19):3453-73. DMPNHF0 RU https://pubmed.ncbi.nlm.nih.gov/10999999 DM4VY8S DI DM4VY8S DM4VY8S DN Ro-43-8857 DM4VY8S MI TTJA1ZO DM4VY8S MN ITGB3 messenger RNA (ITGB3 mRNA) DM4VY8S MT DTT DM4VY8S MA Inhibitor DM4VY8S RN Platelet glycoprotein IIb-IIIa antagonists as prototypical integrin blockers: novel parenteral and potential oral antithrombotic agents. J Med Chem. 2000 Sep 21;43(19):3453-73. DM4VY8S RU https://pubmed.ncbi.nlm.nih.gov/10999999 DMRT6FV DI DMRT6FV DMRT6FV DN Ro-46-2005 DMRT6FV MI TTCV6O0 DMRT6FV MN Endothelin receptor (EDNR) DMRT6FV MT DTT DMRT6FV MA Modulator DMRT6FV RN In vitro characterization of Ro 46-2005, a novel synthetic non-peptide endothelin antagonist of ETA and ETB receptors. FEBS Lett. 1993 Nov 15;334(2):210-4. DMRT6FV RU https://pubmed.ncbi.nlm.nih.gov/8224248 DMU9JAH DI DMU9JAH DMU9JAH DN Ro-46-5934 DMU9JAH MI TT1RS9F DMU9JAH MN Acetylcholinesterase (AChE) DMU9JAH MT DTT DMU9JAH MA Inhibitor DMU9JAH RN A novel acetylcholinesterase inhibitor, Ro 46-5934, which interacts with muscarinic M2 receptors. Biochem Soc Trans. 1994 Aug;22(3):755-8. DMU9JAH RU https://pubmed.ncbi.nlm.nih.gov/7821679 DMXMP3D DI DMXMP3D DMXMP3D DN Ro-48-1220 DMXMP3D MI TTHI19T DMXMP3D MN Staphylococcus Beta-lactamase (Stap-coc blaZ) DMXMP3D MT DTT DMXMP3D MA Modulator DMXMP3D RN Comparative in vitro activity of apalcillin alone and combined with Ro 48-1220, a novel penam beta-lactamase inhibitor. Clin Microbiol Infect. 1995 Feb;1(2):86-100. DMXMP3D RU https://pubmed.ncbi.nlm.nih.gov/11866735 DM7AUF2 DI DM7AUF2 DM7AUF2 DN Ro-48-5545 DM7AUF2 MI TTHI19T DM7AUF2 MN Staphylococcus Beta-lactamase (Stap-coc blaZ) DM7AUF2 MT DTT DM7AUF2 MA Inhibitor DM7AUF2 RN Potentiation of beta-lactams against Pseudomonas aeruginosa strains by Ro 48-1256, a bridged monobactam inhibitor of AmpC beta-lactamases. J Antimicrob Chemother. 1997 Sep;40(3):335-43. DM7AUF2 RU https://pubmed.ncbi.nlm.nih.gov/9338484 DM0RZEO DI DM0RZEO DM0RZEO DN Ro-48-8724 DM0RZEO MI TTHI19T DM0RZEO MN Staphylococcus Beta-lactamase (Stap-coc blaZ) DM0RZEO MT DTT DM0RZEO MA Modulator DM0RZEO RN Activity of a broad-spectrum cephalosporin (Ro 48-8391) alone and in combination with two novel beta-lactamase inhibitors (Ro 48-5545 and Ro 48-8724). Diagn Microbiol Infect Dis. 1998 Oct;32(2):85-94. DM0RZEO RU https://pubmed.ncbi.nlm.nih.gov/9823530 DMZSQU8 DI DMZSQU8 DMZSQU8 DN Ro-60-0175 DMZSQU8 MI TTJQOD7 DMZSQU8 MN 5-HT 2A receptor (HTR2A) DMZSQU8 MT DTT DMZSQU8 MA Inhibitor DMZSQU8 RN Synthesis and structure-activity relationships of a series of substituted 2-(1H-furo[2,3-g]indazol-1-yl)ethylamine derivatives as 5-HT2C receptor a... Bioorg Med Chem. 2008 Feb 15;16(4):1966-82. DMZSQU8 RU https://pubmed.ncbi.nlm.nih.gov/18035544 DMZSQU8 DI DMZSQU8 DMZSQU8 DN Ro-60-0175 DMZSQU8 MI TT0K1SC DMZSQU8 MN 5-HT 2B receptor (HTR2B) DMZSQU8 MT DTT DMZSQU8 MA Inhibitor DMZSQU8 RN Pyrrolo(iso)quinoline derivatives as 5-HT(2C) receptor agonists. Bioorg Med Chem Lett. 2006 Feb;16(3):677-80. DMZSQU8 RU https://pubmed.ncbi.nlm.nih.gov/16257207 DMZSQU8 DI DMZSQU8 DMZSQU8 DN Ro-60-0175 DMZSQU8 MI TTWJBZ5 DMZSQU8 MN 5-HT 2C receptor (HTR2C) DMZSQU8 MT DTT DMZSQU8 MA Inhibitor DMZSQU8 RN Synthesis and structure-activity relationships of a series of substituted 2-(1H-furo[2,3-g]indazol-1-yl)ethylamine derivatives as 5-HT2C receptor a... Bioorg Med Chem. 2008 Feb 15;16(4):1966-82. DMZSQU8 RU https://pubmed.ncbi.nlm.nih.gov/18035544 DM6JO30 DI DM6JO30 DM6JO30 DN Rogletimide DM6JO30 MI TTSZLWK DM6JO30 MN Aromatase (CYP19A1) DM6JO30 MT DTT DM6JO30 MA Inhibitor DM6JO30 RN Analogues of 3-ethyl-3-(4-pyridyl)piperidine-2,6-dione as selective inhibitors of aromatase: derivatives with variable 1-alkyl and 3-alkyl substitu... J Med Chem. 1987 Sep;30(9):1550-4. DM6JO30 RU https://pubmed.ncbi.nlm.nih.gov/3625703 DM4VCJI DI DM4VCJI DM4VCJI DN Rovelizumab DM4VCJI MI TTD26RC DM4VCJI MN Cell adhesion molecule (CADM) DM4VCJI MT DTT DM4VCJI RN Rovelizumab (ICOS Corp). IDrugs. 2000 Apr;3(4):442-6. DM4VCJI RU https://pubmed.ncbi.nlm.nih.gov/16100700 DMQZ2JA DI DMQZ2JA DMQZ2JA DN RP-58802B DMQZ2JA MI TT2CJVK DMQZ2JA MN Adrenergic receptor beta-2 (ADRB2) DMQZ2JA MT DTT DMQZ2JA MA Modulator DMQZ2JA RN RP 58802B, a long-acting beta 2-adrenoceptor agonist: assessment of antiasthma activity in the guinea-pig in vivo. Pulm Pharmacol. 1992 Sep;5(3):203-12. DMQZ2JA RU https://pubmed.ncbi.nlm.nih.gov/1280178 DM09QLY DI DM09QLY DM09QLY DN RP-66055 DM09QLY MI TTRK8B9 DM09QLY MN Sodium channel unspecific (NaC) DM09QLY MT DTT DM09QLY MA Modulator DM09QLY RN Synthesis, anticonvulsant and neuroprotective activities of RP 66055, a riluzole derivative. Bioorg Med Chem. 1994 Aug;2(8):793-8. DM09QLY RU https://pubmed.ncbi.nlm.nih.gov/7894973 DMX4E75 DI DMX4E75 DMX4E75 DN RP-66153 DMX4E75 MI TTN53ZF DMX4E75 MN Leukotriene B4 receptor 1 (LTB4R) DMX4E75 MT DTT DMX4E75 MA Modulator DMX4E75 RN Omega-[(omega-arylalkyl)thienyl]alkanoic acids: from specific LTA4 hydrolase inhibitors to LTB4 receptor antagonists. J Med Chem. 1992 Aug 21;35(17):3170-9. DMX4E75 RU https://pubmed.ncbi.nlm.nih.gov/1324316 DM6HJX7 DI DM6HJX7 DM6HJX7 DN RP-66364 DM6HJX7 MI TTN53ZF DM6HJX7 MN Leukotriene B4 receptor 1 (LTB4R) DM6HJX7 MT DTT DM6HJX7 MA Modulator DM6HJX7 RN WO patent application no. 1997,0297,75, Compositions comprising a cyclooxygenase-2 inhibitor and a leukotriene b4 receptor antagonist. DM6HJX7 RU http://www.google.com/patents/WO1997029775A1?cl=en DM6HJX7 DI DM6HJX7 DM6HJX7 DN RP-66364 DM6HJX7 MI TTK0943 DM6HJX7 MN Prostaglandin G/H synthase (COX) DM6HJX7 MT DTT DM6HJX7 MA Modulator DM6HJX7 RN WO patent application no. 1997,0297,75, Compositions comprising a cyclooxygenase-2 inhibitor and a leukotriene b4 receptor antagonist. DM6HJX7 RU http://www.google.com/patents/WO1997029775A1?cl=en DM2GV78 DI DM2GV78 DM2GV78 DN RP-66784 DM2GV78 MI TT1VOHK DM2GV78 MN Potassium channel unspecific (KC) DM2GV78 MT DTT DM2GV78 MA Opener DM2GV78 RN Syntheses and biological activities of potent potassium channel openers derived from (+/-)-2-oxo-1-pyridin-3-yl-cyclohexanecarbothioic acid methylamide: new potassium channel openers. J Med Chem. 1993 May 28;36(11):1604-12. DM2GV78 RU https://pubmed.ncbi.nlm.nih.gov/8496928 DMDLW64 DI DMDLW64 DMDLW64 DN RP-67580 DMDLW64 MI TTZPO1L DMDLW64 MN Substance-P receptor (TACR1) DMDLW64 MT DTT DMDLW64 MA Antagonist DMDLW64 RN Effects of RP 67580, a tachykinin NK1 receptor antagonist, on a primary afferent-evoked response of ventral roots in the neonatal rat spinal cord. Br J Pharmacol. 1994 Dec;113(4):1141-6. DMDLW64 RU https://pubmed.ncbi.nlm.nih.gov/7534180 DM0BEM3 DI DM0BEM3 DM0BEM3 DN RP-68303 DM0BEM3 MI TTJQOD7 DM0BEM3 MN 5-HT 2A receptor (HTR2A) DM0BEM3 MT DTT DM0BEM3 MA Inhibitor DM0BEM3 RN New indole derivatives as potent and selective serotonin uptake inhibitors. J Med Chem. 1993 Apr 30;36(9):1194-202. DM0BEM3 RU https://pubmed.ncbi.nlm.nih.gov/8487257 DMUY4FD DI DMUY4FD DMUY4FD DN RP-69698 DMUY4FD MI TTN53ZF DMUY4FD MN Leukotriene B4 receptor 1 (LTB4R) DMUY4FD MT DTT DMUY4FD MA Modulator DMUY4FD RN omega-[(4,6-Diphenyl-2-pyridyl)oxy]alkanoic acid derivatives: a new family of potent and orally active LTB4 antagonists. J Med Chem. 1992 Nov 13;35(23):4315-24. DMUY4FD RU https://pubmed.ncbi.nlm.nih.gov/1333012 DMHO5AG DI DMHO5AG DMHO5AG DN RP-70676 DMHO5AG MI TTMF541 DMHO5AG MN Liver carboxylesterase (CES1) DMHO5AG MT DTT DMHO5AG MA Modulator DMHO5AG RN Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800002876) DMHO5AG RU http://adisinsight.springer.com/drugs/800002876 DMO3FYI DI DMO3FYI DMO3FYI DN RP-73163 DMO3FYI MI TTMF541 DMO3FYI MN Liver carboxylesterase (CES1) DMO3FYI MT DTT DMO3FYI MA Modulator DMO3FYI RN Hypolipidaemic properties of a potent and bioavailable alkylsulphinyl-diphenylimidazole ACAT inhibitor (RP 73163) in animals fed diets low in cholesterol. Biochem Pharmacol. 1996 Oct 25;52(8):1177-86. DMO3FYI RU https://pubmed.ncbi.nlm.nih.gov/8937424 DMUCP8K DI DMUCP8K DMUCP8K DN RPK-739 DMUCP8K MI TTNYZG2 DMUCP8K MN Granulocyte-macrophage colony-stimulating factor (CSF2) DMUCP8K MT DTT DMUCP8K MA Modulator DMUCP8K RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. DMUCP8K RU https://www.fda.gov/ DM1U0TB DI DM1U0TB DM1U0TB DN RPR 200765A DM1U0TB MI TTVKILB DM1U0TB MN Prostaglandin G/H synthase 2 (COX-2) DM1U0TB MT DTT DM1U0TB MA Inhibitor DM1U0TB RN The discovery of RPR 200765A, a p38 MAP kinase inhibitor displaying a good oral anti-arthritic efficacy. Bioorg Med Chem. 2001 Feb;9(2):537-54. DM1U0TB RU https://pubmed.ncbi.nlm.nih.gov/11249145 DM21Y75 DI DM21Y75 DM21Y75 DN RPR-101821 DM21Y75 MI TTFQEO5 DM21Y75 MN Squalene synthetase (FDFT1) DM21Y75 MT DTT DM21Y75 MA Modulator DM21Y75 RN RPR 101821, a new potent cholesterol-lowering agent: inhibition of squalene synthase and 7-dehydrocholesterol reductase. Naunyn Schmiedebergs Arch Pharmacol. 1996 Jan;353(2):233-40. DM21Y75 RU https://pubmed.ncbi.nlm.nih.gov/8717165 DM9L50N DI DM9L50N DM9L50N DN RPR-104632 DM9L50N MI TTLD29N DM9L50N MN Glutamate receptor ionotropic NMDA 1 (NMDAR1) DM9L50N MT DTT DM9L50N MA Inhibitor DM9L50N RN Indeno[1,2-b]pyrazin-2,3-diones: a new class of antagonists at the glycine site of the NMDA receptor with potent in vivo activity. J Med Chem. 2000 Jun 15;43(12):2371-81. DM9L50N RU https://pubmed.ncbi.nlm.nih.gov/10882363 DM9L50N DI DM9L50N DM9L50N DN RPR-104632 DM9L50N MI TTKJEMQ DM9L50N MN Glutamate receptor ionotropic NMDA 2A (NMDAR2A) DM9L50N MT DTT DM9L50N MA Inhibitor DM9L50N RN Indeno[1,2-b]pyrazin-2,3-diones: a new class of antagonists at the glycine site of the NMDA receptor with potent in vivo activity. J Med Chem. 2000 Jun 15;43(12):2371-81. DM9L50N RU https://pubmed.ncbi.nlm.nih.gov/10882363 DM9L50N DI DM9L50N DM9L50N DN RPR-104632 DM9L50N MI TTN9D8E DM9L50N MN Glutamate receptor ionotropic NMDA 2B (NMDAR2B) DM9L50N MT DTT DM9L50N MA Inhibitor DM9L50N RN Indeno[1,2-b]pyrazin-2,3-diones: a new class of antagonists at the glycine site of the NMDA receptor with potent in vivo activity. J Med Chem. 2000 Jun 15;43(12):2371-81. DM9L50N RU https://pubmed.ncbi.nlm.nih.gov/10882363 DMJ63GW DI DMJ63GW DMJ63GW DN RPR-113829 DMJ63GW MI TT7WZIJ DMJ63GW MN CAAX farnesyltransferase beta (FNTB) DMJ63GW MT DTT DMJ63GW MA Inhibitor DMJ63GW RN Novel conformationally extended naphthalene-based inhibitors of farnesyltransferase. J Med Chem. 1997 Jun 6;40(12):1763-7. DMJ63GW RU https://pubmed.ncbi.nlm.nih.gov/9191950 DMJ63GW DI DMJ63GW DMJ63GW DN RPR-113829 DMJ63GW MI TTXQKM3 DMJ63GW MN Farnesyl protein transferase (Ftase) DMJ63GW MT DTT DMJ63GW MA Inhibitor DMJ63GW RN Novel conformationally extended naphthalene-based inhibitors of farnesyltransferase. J Med Chem. 1997 Jun 6;40(12):1763-7. DMJ63GW RU https://pubmed.ncbi.nlm.nih.gov/9191950 DMAIJT6 DI DMAIJT6 DMAIJT6 DN RPR-114334 DMAIJT6 MI TT7WZIJ DMAIJT6 MN CAAX farnesyltransferase beta (FNTB) DMAIJT6 MT DTT DMAIJT6 MA Inhibitor DMAIJT6 RN Novel conformationally extended naphthalene-based inhibitors of farnesyltransferase. J Med Chem. 1997 Jun 6;40(12):1763-7. DMAIJT6 RU https://pubmed.ncbi.nlm.nih.gov/9191950 DMAIJT6 DI DMAIJT6 DMAIJT6 DN RPR-114334 DMAIJT6 MI TTXQKM3 DMAIJT6 MN Farnesyl protein transferase (Ftase) DMAIJT6 MT DTT DMAIJT6 MA Inhibitor DMAIJT6 RN Novel conformationally extended naphthalene-based inhibitors of farnesyltransferase. J Med Chem. 1997 Jun 6;40(12):1763-7. DMAIJT6 RU https://pubmed.ncbi.nlm.nih.gov/9191950 DMKQV9A DI DMKQV9A DMKQV9A DN RS 86 DMKQV9A MI TTH18TF DMKQV9A MN Muscarinic acetylcholine receptor M5 (CHRM5) DMKQV9A MT DTT DMKQV9A MA Agonist DMKQV9A RN The pharmacological assessment of RS 86 (2-ethyl-8-methyl-2,8-diazaspiro-[4,5]-decan-1,3-dion hydrobromide). A potent, specific muscarinic acetylcholine receptor agonist. Eur J Pharmacol. 1986 Jun 5;125(1):45-62. DMKQV9A RU https://pubmed.ncbi.nlm.nih.gov/3732391 DMFJ0KC DI DMFJ0KC DMFJ0KC DN RS-2135 DMFJ0KC MI TTRK8B9 DMFJ0KC MN Sodium channel unspecific (NaC) DMFJ0KC MT DTT DMFJ0KC MA Modulator DMFJ0KC RN Electrophysiologic effects of RS-2135, a new antiarrhythmic compound, on canine Purkinje fibers. J Cardiovasc Pharmacol. 1992 Dec;20(6):955-60. DMFJ0KC RU https://pubmed.ncbi.nlm.nih.gov/1282599 DMT5DH0 DI DMT5DH0 DMT5DH0 DN RS-66252 DMT5DH0 MI TT8DBY3 DMT5DH0 MN Angiotensin II receptor type-1 (AGTR1) DMT5DH0 MT DTT DMT5DH0 MA Modulator DMT5DH0 RN Virtual Screening in Drug Discovery, Juan Alvarez Brian Shoichet. Page(218). DMT5DH0 RU https://books.google.com.hk/books?id=Yj9HgUgq_uwC&pg=PA218&lpg=PA218&dq=RS-66252++++angiotensin+II&source=bl&ots=ohMTzwCVx9&sig=wzHmoRk4h2AhEdyLvkPdYcfjhPk&hl=zh-CN&sa=X&ved=0CB8Q6AEwAGoVChMIzrnc9469yAIVEAmOCh0byQrL DMZHS9U DI DMZHS9U DMZHS9U DN RS-93522 DMZHS9U MI TT5HONZ DMZHS9U MN Calcium channel unspecific (CaC) DMZHS9U MT DTT DMZHS9U MA Blocker DMZHS9U RN Intranasal delivery of RS-93522, a dihydropyridine-type calcium-channel antagonist. Pharm Res. 1991 Jan;8(1):134-5. DMZHS9U RU https://pubmed.ncbi.nlm.nih.gov/2014202 DMVW3I9 DI DMVW3I9 DMVW3I9 DN RU 24969 DMVW3I9 MI TTWT5K7 DMVW3I9 MN 5-HT 1 receptor (5HT1R) DMVW3I9 MT DTT DMVW3I9 MA Agonist DMVW3I9 RN Effect of chronic treatment with 5-HT1 agonist (8-OH-DPAT and RU 24969) and antagonist (isapirone) drugs on the behavioural responses of mice to 5-HT1 and 5-HT2 agonists. Br J Pharmacol. 1986 Oct;89(2):377-84. DMVW3I9 RU https://pubmed.ncbi.nlm.nih.gov/2946344 DMSWFMQ DI DMSWFMQ DMSWFMQ DN RU-33965 DMSWFMQ MI TTEX6LM DMSWFMQ MN GABA(A) receptor gamma-3 (GABRG3) DMSWFMQ MT DTT DMSWFMQ MA Modulator DMSWFMQ RN Discriminative stimulus properties of RU 33965, a benzodiazepine receptor weak partial inverse agonist. Pharmacol Biochem Behav. 1992 Oct;43(2):583-8. DMSWFMQ RU https://pubmed.ncbi.nlm.nih.gov/1359581 DM8B1DH DI DM8B1DH DM8B1DH DN RU-46556 DM8B1DH MI TTUV8G9 DM8B1DH MN Progesterone receptor (PGR) DM8B1DH MT DTT DM8B1DH MA Modulator DM8B1DH RN New analogues of mifepristone with more dissociated antiprogesterone activities. J Steroid Biochem. 1989;34(1-6):413-7. DM8B1DH RU https://pubmed.ncbi.nlm.nih.gov/2560520 DMBXDQG DI DMBXDQG DMBXDQG DN RWJ-22108 DMBXDQG MI TT5HONZ DMBXDQG MN Calcium channel unspecific (CaC) DMBXDQG MT DTT DMBXDQG MA Modulator DMBXDQG RN Design and discovery of RWJ 22108--a novel bronchoselective calcium channel blocker. Drug Des Discov. 1998 May;15(3):135-48. DMBXDQG RU https://pubmed.ncbi.nlm.nih.gov/9689497 DMRQZWN DI DMRQZWN DMRQZWN DN RWJ-25730 DMRQZWN MI TTSQIFT DMRQZWN MN 5-HT 1A receptor (HTR1A) DMRQZWN MT DTT DMRQZWN MA Modulator DMRQZWN RN Piperazinylalkyl heterocycles as potential antipsychotic agents. J Med Chem. 1995 Oct 13;38(21):4198-210. DMRQZWN RU https://www.ncbi.nlm.nih.gov/pubmed/7473547 DMRQZWN DI DMRQZWN DMRQZWN DN RWJ-25730 DMRQZWN MI TTEX248 DMRQZWN MN Dopamine D2 receptor (D2R) DMRQZWN MT DTT DMRQZWN MA Modulator DMRQZWN RN Piperazinylalkyl heterocycles as potential antipsychotic agents. J Med Chem. 1995 Oct 13;38(21):4198-210. DMRQZWN RU https://www.ncbi.nlm.nih.gov/pubmed/7473547 DM17WNG DI DM17WNG DM17WNG DN RWJ-37868 DM17WNG MI TT5HONZ DM17WNG MN Calcium channel unspecific (CaC) DM17WNG MT DTT DM17WNG MA Modulator DM17WNG RN Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800008896) DM17WNG RU http://adisinsight.springer.com/drugs/800008896 DMEO7YD DI DMEO7YD DMEO7YD DN RWJ-46458 DMEO7YD MI TTGN1ZA DMEO7YD MN Angiotensin II receptor (AGTR) DMEO7YD MT DTT DMEO7YD MA Modulator DMEO7YD RN WO patent application no. 1996,0402,58, Spironolactone and angiotensin ii antagonist combination therapy for treatment of congestive heart failure. DMEO7YD RU http://www.google.com/patents/WO1996040258A2?cl=en DMUGZMO DI DMUGZMO DMUGZMO DN RWJ-49815 DMUGZMO MI TTJVCG0 DMUGZMO MN Bacterial Sporulation kinase A (Bact kinA) DMUGZMO MT DTT DMUGZMO MA Inhibitor DMUGZMO RN Histidine kinases as targets for new antimicrobial agents. Bioorg Med Chem. 2002 Apr;10(4):855-67. DMUGZMO RU https://pubmed.ncbi.nlm.nih.gov/11836091 DMUGZMO DI DMUGZMO DMUGZMO DN RWJ-49815 DMUGZMO MI TTY6EWA DMUGZMO MN Neuropeptide Y receptor type 5 (NPY5R) DMUGZMO MT DTT DMUGZMO MA Antagonist DMUGZMO RN Emerging drugs for eating disorder treatment. Expert Opin Emerg Drugs. 2006 May;11(2):315-36. DMUGZMO RU https://pubmed.ncbi.nlm.nih.gov/16634704 DMYXD6A DI DMYXD6A DMYXD6A DN RWJ-58259 DMYXD6A MI TTL935N DMYXD6A MN Proteinase activated receptor 1 (F2R) DMYXD6A MT DTT DMYXD6A MA Modulator DMYXD6A RN RWJ-58259: a selective antagonist of protease activated receptor-1. Cardiovasc Drug Rev. 2003 Winter;21(4):313-26. DMYXD6A RU https://pubmed.ncbi.nlm.nih.gov/14647534 DMUDE1T DI DMUDE1T DMUDE1T DN RWJ-63556 DMUDE1T MI TT2J34L DMUDE1T MN Arachidonate 5-lipoxygenase (5-LOX) DMUDE1T MT DTT DMUDE1T MA Modulator DMUDE1T RN Evaluation of the antiinflammatory activity of a dual cyclooxygenase-2 selective/5-lipoxygenase inhibitor, RWJ 63556, in a canine model of inflammation. J Pharmacol Exp Ther. 1997 Aug;282(2):1094-101. DMUDE1T RU https://pubmed.ncbi.nlm.nih.gov/9262379 DMUDE1T DI DMUDE1T DMUDE1T DN RWJ-63556 DMUDE1T MI TTVKILB DMUDE1T MN Prostaglandin G/H synthase 2 (COX-2) DMUDE1T MT DTT DMUDE1T MA Modulator DMUDE1T RN Evaluation of the antiinflammatory activity of a dual cyclooxygenase-2 selective/5-lipoxygenase inhibitor, RWJ 63556, in a canine model of inflammation. J Pharmacol Exp Ther. 1997 Aug;282(2):1094-101. DMUDE1T RU https://pubmed.ncbi.nlm.nih.gov/9262379 DMDQGFR DI DMDQGFR DMDQGFR DN S-1389 DMDQGFR MI TT1VOHK DMDQGFR MN Potassium channel unspecific (KC) DMDQGFR MT DTT DMDQGFR MA Opener DMDQGFR RN Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800000214) DMDQGFR RU http://adisinsight.springer.com/drugs/800000214 DM759KX DI DM759KX DM759KX DN S-14080 DM759KX MI TTK0943 DM759KX MN Prostaglandin G/H synthase (COX) DM759KX MT DTT DM759KX MA Modulator DM759KX RN US patent application no. 7,022,689, 5-amidino-n-(2-aminophenethyl)-n-hydroxy-benzenesulffonamide derivative, medical composition containing the same, pharmaceutical use thereof and intermediate therefor. DM759KX RU http://www.google.com/patents/US7022689 DM05IQU DI DM05IQU DM05IQU DN S-14506 DM05IQU MI TTSQIFT DM05IQU MN 5-HT 1A receptor (HTR1A) DM05IQU MT DTT DM05IQU MA Modulator DM05IQU RN S 14506: novel receptor coupling at 5-HT(1A) receptors. Neuropharmacology. 2001 Mar;40(3):334-44. DM05IQU RU https://www.ncbi.nlm.nih.gov/pubmed/11166326 DMQ8S4L DI DMQ8S4L DMQ8S4L DN S-18616 DMQ8S4L MI TTWG9A4 DMQ8S4L MN Adrenergic receptor alpha-2A (ADRA2A) DMQ8S4L MT DTT DMQ8S4L MA Modulator DMQ8S4L RN S18616, a highly potent spiroimidazoline agonist at alpha(2)-adrenoceptors: II. Influence on monoaminergic transmission, motor function, and anxiety in comparison with dexmedetomidine and clonidine. J Pharmacol Exp Ther. 2000 Dec;295(3):1206-22. DMQ8S4L RU https://pubmed.ncbi.nlm.nih.gov/11082458 DMQDWMJ DI DMQDWMJ DMQDWMJ DN S-20928 DMQDWMJ MI TT0WAIE DMQDWMJ MN Melatonin receptor type 1A (MTNR1A) DMQDWMJ MT DTT DMQDWMJ MA Modulator DMQDWMJ RN Effects of two melatonin analogues, S-20098 and S-20928, on melatonin receptors in the pars tuberalis of the rat. J Pineal Res. 1998 Oct;25(3):172-6. DMQDWMJ RU https://pubmed.ncbi.nlm.nih.gov/9745986 DMF710M DI DMF710M DMF710M DN S-33516 DMF710M MI TTVKILB DMF710M MN Prostaglandin G/H synthase 2 (COX-2) DMF710M MT DTT DMF710M MA Inhibitor DMF710M RN S 33516 Servier preclinical data. R & D Focus Drug News. July 12, 1999. DMF710M RU http://business.highbeam.com/436989/article-1G1-56540224/s-33516-servier-preclinical-data DMPQIUH DI DMPQIUH DMPQIUH DN S-34109 DMPQIUH MI TTN6J5F DMPQIUH MN Bacterial DNA gyrase (Bact gyrase) DMPQIUH MT DTT DMPQIUH MA Modulator DMPQIUH RN Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800007670) DMPQIUH RU http://adisinsight.springer.com/drugs/800007670 DMEN6YO DI DMEN6YO DMEN6YO DN Sameridine DMEN6YO MI TTKWM86 DMEN6YO MN Opioid receptor mu (MOP) DMEN6YO MT DTT DMEN6YO MA Modulator DMEN6YO RN The effects on resting ventilation of intravenous infusions of morphine or sameridine, a novel molecule with both local anesthetic and opioid properties. Anesth Analg. 1999 Jan;88(1):160-5. DMEN6YO RU https://pubmed.ncbi.nlm.nih.gov/9895085 DMGUA9Y DI DMGUA9Y DMGUA9Y DN SAN-61 DMGUA9Y MI TTRSMW9 DMGUA9Y MN Glycogen synthase kinase-3 beta (GSK-3B) DMGUA9Y MT DTT DMGUA9Y MA Inhibitor DMGUA9Y RN Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800029796) DMGUA9Y RU http://adisinsight.springer.com/drugs/800029796 DM79E6W DI DM79E6W DM79E6W DN Saviprazole DM79E6W MI TTLOKXP DM79E6W MN Gastric H(+)/K(+) ATPase (Proton pump) DM79E6W MT DTT DM79E6W MA Modulator DM79E6W RN Gastric acid inhibitory profile of saviprazole (HOE 731) compared to omeprazole. Pharmacology. 1991;43(6):293-303. DM79E6W RU https://pubmed.ncbi.nlm.nih.gov/1664524 DMNJ7LY DI DMNJ7LY DMNJ7LY DN SB 203186 DMNJ7LY MI TT07C3Y DMNJ7LY MN 5-HT 4 receptor (HTR4) DMNJ7LY MT DTT DMNJ7LY MA Antagonist DMNJ7LY RN 5-Hydroxytryptamine mediated contractions in isolated preparations of equine ileum and pelvic flexure: pharmacological characterization of a new 5-HT(4) agonist. J Vet Pharmacol Ther. 2002 Feb;25(1):49-58. DMNJ7LY RU https://pubmed.ncbi.nlm.nih.gov/11874527 DMAET6F DI DMAET6F DMAET6F DN SB 203580 DMAET6F MI TTWOTEA DMAET6F MN Interleukin 1 receptor type 1 (IL1R1) DMAET6F MT DTT DMAET6F MA Antagonist DMAET6F RN IL-1- and TNF-induced bone resorption is mediated by p38 mitogen activated protein kinase. J Cell Physiol. 2001 Jun;187(3):294-303. DMAET6F RU https://pubmed.ncbi.nlm.nih.gov/11319753 DMAET6F DI DMAET6F DMAET6F DN SB 203580 DMAET6F MI TTVKILB DMAET6F MN Prostaglandin G/H synthase 2 (COX-2) DMAET6F MT DTT DMAET6F MA Inhibitor DMAET6F RN Inhibition of p38 MAP kinase as a therapeutic strategy. Immunopharmacology. 2000 May;47(2-3):185-201. DMAET6F RU https://pubmed.ncbi.nlm.nih.gov/10878289 DMAET6F DI DMAET6F DMAET6F DN SB 203580 DMAET6F MI TTQBR95 DMAET6F MN Stress-activated protein kinase 2a (p38 alpha) DMAET6F MT DTT DMAET6F MA Inhibitor DMAET6F RN The p38 mitogen-activated protein kinase pathway plays a critical role in thrombin-induced endothelial chemokine production and leukocyte recruitment. Blood. 2001 Aug 1;98(3):667-73. DMAET6F RU https://pubmed.ncbi.nlm.nih.gov/11468165 DMS0QEP DI DMS0QEP DMS0QEP DN SB 206553 DMS0QEP MI TT0K1SC DMS0QEP MN 5-HT 2B receptor (HTR2B) DMS0QEP MT DTT DMS0QEP MA Antagonist DMS0QEP RN Strain-dependent effects of diazepam and the 5-HT2B/2C receptor antagonist SB 206553 in spontaneously hypertensive and Lewis rats tested in the elevated plus-maze. Braz J Med Biol Res. 2001 May;34(5):675-82. DMS0QEP RU https://pubmed.ncbi.nlm.nih.gov/11323756 DMGNZUX DI DMGNZUX DMGNZUX DN SB-201146 DMGNZUX MI TTN53ZF DMGNZUX MN Leukotriene B4 receptor 1 (LTB4R) DMGNZUX MT DTT DMGNZUX MA Inhibitor DMGNZUX RN (E)-3-[6-[[(2,6-dichlorophenyl)thio]methyl]-3-(2-phenylethoxy)-2- pyridinyl]-2-propenoic acid: a high-affinity leukotriene B4 receptor antagonist w... J Med Chem. 1996 Sep 13;39(19):3837-41. DMGNZUX RU https://pubmed.ncbi.nlm.nih.gov/8809171 DM5ZPQJ DI DM5ZPQJ DM5ZPQJ DN SB-206284A DM5ZPQJ MI TT5HONZ DM5ZPQJ MN Calcium channel unspecific (CaC) DM5ZPQJ MT DTT DM5ZPQJ MA Modulator DM5ZPQJ RN The effects of SB 206284A, a novel neuronal calcium-channel antagonist, in models of cerebral ischemia. J Cereb Blood Flow Metab. 1997 Apr;17(4):421-9. DM5ZPQJ RU https://pubmed.ncbi.nlm.nih.gov/9143224 DMYFE23 DI DMYFE23 DMYFE23 DN SB-206343 DMYFE23 MI TT5FNQT DMYFE23 MN Human immunodeficiency virus Protease (HIV PR) DMYFE23 MT DTT DMYFE23 MA Modulator DMYFE23 RN Rational design, synthesis, and crystallographic analysis of a hydroxyethylene-based HIV-1 protease inhibitor containing a heterocyclic P1'--P2' amide bond isostere. J Med Chem. 1994 Sep 16;37(19):3100-7. DMYFE23 RU https://pubmed.ncbi.nlm.nih.gov/7932533 DMJD15H DI DMJD15H DMJD15H DN SB-208651 DMJD15H MI TT38RM1 DMJD15H MN Glycoprotein IIb/IIIa receptor (GPIIb/IIIa) DMJD15H MT DTT DMJD15H MA Modulator DMJD15H RN Design of a potent and orally active nonpeptide platelet fibrinogen receptor (GPIIb/IIIa) antagonist. Bioorg Med Chem. 1994 Sep;2(9):897-908. DMJD15H RU https://www.ncbi.nlm.nih.gov/pubmed/7712125 DMVBNTP DI DMVBNTP DMVBNTP DN SB-209247 DMVBNTP MI TTN53ZF DMVBNTP MN Leukotriene B4 receptor 1 (LTB4R) DMVBNTP MT DTT DMVBNTP MA Antagonist DMVBNTP RN Formation and protein binding of the acyl glucuronide of a leukotriene B4 antagonist (SB-209247): relation to species differences in hepatotoxicity. Drug Metab Dispos. 2005 Feb;33(2):271-81. DMVBNTP RU https://pubmed.ncbi.nlm.nih.gov/15523047 DM58PKG DI DM58PKG DM58PKG DN SB-213698 DM58PKG MI TT27RFC DM58PKG MN Opioid receptor delta (OPRD1) DM58PKG MT DTT DM58PKG MA Inhibitor DM58PKG RN Design and synthesis of novel delta opioid receptor agonists and their pharmacologies. Bioorg Med Chem Lett. 2009 May 15;19(10):2792-5. DM58PKG RU https://pubmed.ncbi.nlm.nih.gov/19362480 DM58PKG DI DM58PKG DM58PKG DN SB-213698 DM58PKG MI TTQW87Y DM58PKG MN Opioid receptor kappa (OPRK1) DM58PKG MT DTT DM58PKG MA Inhibitor DM58PKG RN Design and synthesis of novel delta opioid receptor agonists and their pharmacologies. Bioorg Med Chem Lett. 2009 May 15;19(10):2792-5. DM58PKG RU https://pubmed.ncbi.nlm.nih.gov/19362480 DM58PKG DI DM58PKG DM58PKG DN SB-213698 DM58PKG MI TTKWM86 DM58PKG MN Opioid receptor mu (MOP) DM58PKG MT DTT DM58PKG MA Inhibitor DM58PKG RN Design and synthesis of novel delta opioid receptor agonists and their pharmacologies. Bioorg Med Chem Lett. 2009 May 15;19(10):2792-5. DM58PKG RU https://pubmed.ncbi.nlm.nih.gov/19362480 DMQW6B0 DI DMQW6B0 DMQW6B0 DN SB-219825 DMQW6B0 MI TT27RFC DMQW6B0 MN Opioid receptor delta (OPRD1) DMQW6B0 MT DTT DMQW6B0 MA Modulator DMQW6B0 RN Mutation W284L of the human delta opioid receptor reveals agonist specific receptor conformations for G protein activation. Life Sci. 2001 Apr 6;68(19-20):2233-42. DMQW6B0 RU https://pubmed.ncbi.nlm.nih.gov/11358332 DMCZDE9 DI DMCZDE9 DMCZDE9 DN SB-219994 DMCZDE9 MI TTZMAO3 DMCZDE9 MN Peroxisome proliferator-activated receptor gamma (PPAR-gamma) DMCZDE9 MT DTT DMCZDE9 MA Agonist DMCZDE9 RN PPAR-gamma agonists as therapy for diseases involving airway neutrophilia. Eur Respir J. 2004 Jul;24(1):18-23. DMCZDE9 RU https://pubmed.ncbi.nlm.nih.gov/15293600 DMSBUET DI DMSBUET DMSBUET DN SB220025 DMSBUET MI TT4TQBX DMSBUET MN Extracellular signal-regulated kinase 2 (ERK2) DMSBUET MT DTT DMSBUET MA Inhibitor DMSBUET RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMSBUET RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMSBUET DI DMSBUET DMSBUET DN SB220025 DMSBUET MI TTQBR95 DMSBUET MN Stress-activated protein kinase 2a (p38 alpha) DMSBUET MT DTT DMSBUET MA Inhibitor DMSBUET RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMSBUET RU https://pubmed.ncbi.nlm.nih.gov/17139284 DM3JQCF DI DM3JQCF DM3JQCF DN SB-223245 DM3JQCF MI TTT1R2L DM3JQCF MN Integrin alpha-V (ITGAV) DM3JQCF MT DTT DM3JQCF MA Inhibitor DM3JQCF RN Discovery of an imidazopyridine-containing 1,4-benzodiazepine nonpeptide vitronectin receptor (alpha v beta 3) antagonist with efficacy in a resten... Bioorg Med Chem Lett. 1998 Nov 17;8(22):3171-6. DM3JQCF RU https://pubmed.ncbi.nlm.nih.gov/9873697 DM3JQCF DI DM3JQCF DM3JQCF DN SB-223245 DM3JQCF MI TTJA1ZO DM3JQCF MN ITGB3 messenger RNA (ITGB3 mRNA) DM3JQCF MT DTT DM3JQCF MA Inhibitor DM3JQCF RN Discovery of an imidazopyridine-containing 1,4-benzodiazepine nonpeptide vitronectin receptor (alpha v beta 3) antagonist with efficacy in a resten... Bioorg Med Chem Lett. 1998 Nov 17;8(22):3171-6. DM3JQCF RU https://pubmed.ncbi.nlm.nih.gov/9873697 DM5JDH1 DI DM5JDH1 DM5JDH1 DN SB-236049 DM5JDH1 MI TTHI19T DM5JDH1 MN Staphylococcus Beta-lactamase (Stap-coc blaZ) DM5JDH1 MT DTT DM5JDH1 MA Inhibitor DM5JDH1 RN Identification of a series of tricyclic natural products as potent broad-spectrum inhibitors of metallo-beta-lactamases. Antimicrob Agents Chemother. 2002 Jun;46(6):1880-6. DM5JDH1 RU https://pubmed.ncbi.nlm.nih.gov/12019104 DMBCANZ DI DMBCANZ DMBCANZ DN SB-237376 DMBCANZ MI TT5HONZ DMBCANZ MN Calcium channel unspecific (CaC) DMBCANZ MT DTT DMBCANZ MA Modulator DMBCANZ RN Electrophysiologic effects of SB-237376: a new antiarrhythmic compound with dual potassium and calcium channel blocking action. J Cardiovasc Pharmacol. 2003 Mar;41(3):414-21. DMBCANZ RU https://pubmed.ncbi.nlm.nih.gov/12605020 DMBCANZ DI DMBCANZ DMBCANZ DN SB-237376 DMBCANZ MI TT1VOHK DMBCANZ MN Potassium channel unspecific (KC) DMBCANZ MT DTT DMBCANZ MA Modulator DMBCANZ RN Electrophysiologic effects of SB-237376: a new antiarrhythmic compound with dual potassium and calcium channel blocking action. J Cardiovasc Pharmacol. 2003 Mar;41(3):414-21. DMBCANZ RU https://pubmed.ncbi.nlm.nih.gov/12605020 DM8WTGA DI DM8WTGA DM8WTGA DN SB-269970 DM8WTGA MI TTO9X1H DM8WTGA MN 5-HT 7 receptor (HTR7) DM8WTGA MT DTT DM8WTGA MA Modulator DM8WTGA RN [(3)H]-SB-269970--A selective antagonist radioligand for 5-HT(7) receptors. Br J Pharmacol. 2000 May;130(2):409-17. DM8WTGA RU https://pubmed.ncbi.nlm.nih.gov/10807680 DM3M16Q DI DM3M16Q DM3M16Q DN SB-277011 DM3M16Q MI TT4C8EA DM3M16Q MN Dopamine D3 receptor (D3R) DM3M16Q MT DTT DM3M16Q MA Antagonist DM3M16Q RN The pipeline and future of drug development in schizophrenia. Mol Psychiatry. 2007 Oct;12(10):904-22. DM3M16Q RU https://pubmed.ncbi.nlm.nih.gov/17667958 DMZLKCF DI DMZLKCF DMZLKCF DN SB-282241 DMZLKCF MI TTFZYTO DMZLKCF MN C-C chemokine receptor type 2 (CCR2) DMZLKCF MT DTT DMZLKCF MA Antagonist DMZLKCF RN Patent EP2727944 A1. DMZLKCF RU http://www.google.com/patents/EP2727944A1?cl=en DM9F7R0 DI DM9F7R0 DM9F7R0 DN SBP-002 DM9F7R0 MI TT0E5SK DM9F7R0 MN Interleukin 6 receptor (IL6R) DM9F7R0 MT DTT DM9F7R0 MA Modulator DM9F7R0 RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. DM9F7R0 RU https://www.fda.gov/ DM1MQ6Z DI DM1MQ6Z DM1MQ6Z DN SC-102 DM1MQ6Z MI TTQBR95 DM1MQ6Z MN Stress-activated protein kinase 2a (p38 alpha) DM1MQ6Z MT DTT DM1MQ6Z MA Inhibitor DM1MQ6Z RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DM1MQ6Z RU https://pubmed.ncbi.nlm.nih.gov/10592235 DMO1URE DI DMO1URE DMO1URE DN SC-236 DMO1URE MI TTVKILB DMO1URE MN Prostaglandin G/H synthase 2 (COX-2) DMO1URE MT DTT DMO1URE MA Inhibitor DMO1URE RN Cyclooxygenase (COX)-2-dependent effects of the inhibitor SC236 when combined with ionizing radiation in mammary tumor cells derived from HER-2/neu mice. Mol Cancer Ther. 2004 Apr;3(4):417-24. DMO1URE RU https://pubmed.ncbi.nlm.nih.gov/15078985 DM7I6VO DI DM7I6VO DM7I6VO DN SC-241 DM7I6VO MI TTIY658 DM7I6VO MN Corticotropin-releasing factor receptor 2 (CRHR2) DM7I6VO MT DTT DM7I6VO MA Modulator DM7I6VO RN US patent application no. 2015,0094,310, Crhr1 antagonists for use in the treatment of patients having crh overactivity. DM7I6VO RU http://www.google.com.ar/patents/US20150094310 DMBPNKT DI DMBPNKT DMBPNKT DN SC-44463 DMBPNKT MI TTXSU2Y DMBPNKT MN Aggrecanase (ADAMTS5) DMBPNKT MT DTT DMBPNKT MA Inhibitor DMBPNKT RN Design and synthesis of a series of (2R)-N(4)-hydroxy-2-(3-hydroxybenzyl)-N(1)- [(1S,2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]butanediamide derivati... J Med Chem. 2001 Oct 11;44(21):3347-50. DMBPNKT RU https://pubmed.ncbi.nlm.nih.gov/11585439 DMBPNKT DI DMBPNKT DMBPNKT DN SC-44463 DMBPNKT MI TTYG6BU DMBPNKT MN Aggrecanase-1 (ADAMTS4) DMBPNKT MT DTT DMBPNKT MA Inhibitor DMBPNKT RN Design and synthesis of a series of (2R)-N(4)-hydroxy-2-(3-hydroxybenzyl)-N(1)- [(1S,2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]butanediamide derivati... J Med Chem. 2001 Oct 11;44(21):3347-50. DMBPNKT RU https://pubmed.ncbi.nlm.nih.gov/11585439 DMBPNKT DI DMBPNKT DMBPNKT DN SC-44463 DMBPNKT MI TTMX39J DMBPNKT MN Matrix metalloproteinase-1 (MMP-1) DMBPNKT MT DTT DMBPNKT MA Inhibitor DMBPNKT RN A potent, selective inhibitor of matrix metalloproteinase-3 for the topical treatment of chronic dermal ulcers. J Med Chem. 2003 Jul 31;46(16):3514-25. DMBPNKT RU https://pubmed.ncbi.nlm.nih.gov/12877590 DMBPNKT DI DMBPNKT DMBPNKT DN SC-44463 DMBPNKT MI TTLM12X DMBPNKT MN Matrix metalloproteinase-2 (MMP-2) DMBPNKT MT DTT DMBPNKT MA Inhibitor DMBPNKT RN A potent, selective inhibitor of matrix metalloproteinase-3 for the topical treatment of chronic dermal ulcers. J Med Chem. 2003 Jul 31;46(16):3514-25. DMBPNKT RU https://pubmed.ncbi.nlm.nih.gov/12877590 DMBPNKT DI DMBPNKT DMBPNKT DN SC-44463 DMBPNKT MI TTUZ2L5 DMBPNKT MN Matrix metalloproteinase-3 (MMP-3) DMBPNKT MT DTT DMBPNKT MA Inhibitor DMBPNKT RN Amide surrogates of matrix metalloproteinase inhibitors: Urea and sulfonamide mimics, Bioorg. Med. Chem. Lett. 7(18):2331-2336 (1997). DMBPNKT RU http://www.sciencedirect.com/science/article/pii/S0960894X97001820 DMBPNKT DI DMBPNKT DMBPNKT DN SC-44463 DMBPNKT MI TTMTWOS DMBPNKT MN Matrix metalloproteinase-7 (MMP-7) DMBPNKT MT DTT DMBPNKT MA Inhibitor DMBPNKT RN A potent, selective inhibitor of matrix metalloproteinase-3 for the topical treatment of chronic dermal ulcers. J Med Chem. 2003 Jul 31;46(16):3514-25. DMBPNKT RU https://pubmed.ncbi.nlm.nih.gov/12877590 DMBPNKT DI DMBPNKT DMBPNKT DN SC-44463 DMBPNKT MI TTGA1IV DMBPNKT MN Matrix metalloproteinase-8 (MMP-8) DMBPNKT MT DTT DMBPNKT MA Inhibitor DMBPNKT RN Design and synthesis of a series of (2R)-N(4)-hydroxy-2-(3-hydroxybenzyl)-N(1)- [(1S,2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]butanediamide derivati... J Med Chem. 2001 Oct 11;44(21):3347-50. DMBPNKT RU https://pubmed.ncbi.nlm.nih.gov/11585439 DMBPNKT DI DMBPNKT DMBPNKT DN SC-44463 DMBPNKT MI TT6X50U DMBPNKT MN Matrix metalloproteinase-9 (MMP-9) DMBPNKT MT DTT DMBPNKT MA Inhibitor DMBPNKT RN Design and synthesis of a series of (2R)-N(4)-hydroxy-2-(3-hydroxybenzyl)-N(1)- [(1S,2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]butanediamide derivati... J Med Chem. 2001 Oct 11;44(21):3347-50. DMBPNKT RU https://pubmed.ncbi.nlm.nih.gov/11585439 DMIE039 DI DMIE039 DMIE039 DN SC-47643 DMIE039 MI TTJA1ZO DMIE039 MN ITGB3 messenger RNA (ITGB3 mRNA) DMIE039 MT DTT DMIE039 MA Inhibitor DMIE039 RN Novel thiazole-based heterocycles as selective inhibitors of fibrinogen-mediated platelet aggregation. J Med Chem. 1995 Jan 6;38(1):34-41. DMIE039 RU https://pubmed.ncbi.nlm.nih.gov/7837237 DMIE039 DI DMIE039 DMIE039 DN SC-47643 DMIE039 MI TTD0652 DMIE039 MN Proteinase activated receptor 4 (F2RL3) DMIE039 MT DTT DMIE039 MA Inhibitor DMIE039 RN Novel thiazole-based heterocycles as selective inhibitors of fibrinogen-mediated platelet aggregation. J Med Chem. 1995 Jan 6;38(1):34-41. DMIE039 RU https://pubmed.ncbi.nlm.nih.gov/7837237 DMY7KHW DI DMY7KHW DMY7KHW DN SC-49992 DMY7KHW MI TT38RM1 DMY7KHW MN Glycoprotein IIb/IIIa receptor (GPIIb/IIIa) DMY7KHW MT DTT DMY7KHW MA Modulator DMY7KHW RN SC-49992--a potent and specific inhibitor of platelet aggregation. Thromb Res. 1994 Jun 1;74(5):523-35. DMY7KHW RU https://www.ncbi.nlm.nih.gov/pubmed/8085253 DM8UDSF DI DM8UDSF DM8UDSF DN SC-50560 DM8UDSF MI TTQVOEI DM8UDSF MN Angiotensin II receptor type-2 (AGTR2) DM8UDSF MT DTT DM8UDSF MA Inhibitor DM8UDSF RN N1-sterically hindered 2H-imidazol-2-one angiotensin II receptor antagonists: The conversion of surmountable antagonists to insurmountable antagonists, Bioorg. Med. Chem. Lett. 3(6):1055-1060 (1993). DM8UDSF RU http://www.sciencedirect.com/science/article/pii/S0960894X00802863 DMI0QZ3 DI DMI0QZ3 DMI0QZ3 DN SC-51146 DMI0QZ3 MI TTN53ZF DMI0QZ3 MN Leukotriene B4 receptor 1 (LTB4R) DMI0QZ3 MT DTT DMI0QZ3 MA Inhibitor DMI0QZ3 RN Synthesis and pharmacological activity of SC-53228, a leukotriene B4 receptor antagonist with high intrinsic potency and selectivity, Bioorg. Med. Chem. Lett. 4(6):811-816 (1994). DMI0QZ3 RU http://www.sciencedirect.com/science/article/pii/S0960894X01808532 DMB26LO DI DMB26LO DMB26LO DN SC-51316 DMB26LO MI TTGN1ZA DMB26LO MN Angiotensin II receptor (AGTR) DMB26LO MT DTT DMB26LO MA Modulator DMB26LO RN In vitro pharmacology of a nonpeptidic angiotensin II receptor antagonist, SC-51316. J Pharmacol Exp Ther. 1992 Jun;261(3):1037-43. DMB26LO RU https://pubmed.ncbi.nlm.nih.gov/1602371 DMWO107 DI DMWO107 DMWO107 DN SC-51895 DMWO107 MI TTQVOEI DMWO107 MN Angiotensin II receptor type-2 (AGTR2) DMWO107 MT DTT DMWO107 MA Inhibitor DMWO107 RN N1-sterically hindered 2H-imidazol-2-one angiotensin II receptor antagonists: The conversion of surmountable antagonists to insurmountable antagonists, Bioorg. Med. Chem. Lett. 3(6):1055-1060 (1993). DMWO107 RU http://www.sciencedirect.com/science/article/pii/S0960894X00802863 DMKWJ59 DI DMKWJ59 DMKWJ59 DN SC-52150 DMKWJ59 MI TTNXLKE DMKWJ59 MN 5-HT 3 receptor (5HT3R) DMKWJ59 MT DTT DMKWJ59 MA Modulator DMKWJ59 RN Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800001830) DMKWJ59 RU http://adisinsight.springer.com/drugs/800001830 DM2O8SF DI DM2O8SF DM2O8SF DN SC-53116 DM2O8SF MI TT07C3Y DM2O8SF MN 5-HT 4 receptor (HTR4) DM2O8SF MT DTT DM2O8SF MA Modulator DM2O8SF RN Bridgehead-methyl analog of SC-53116 as a 5-HT4 agonist. Bioorg Med Chem Lett. 2004 Jun 21;14(12):3073-5. DM2O8SF RU https://www.ncbi.nlm.nih.gov/pubmed/15149647 DMSKHGQ DI DMSKHGQ DMSKHGQ DN SC-53228 DMSKHGQ MI TTN53ZF DMSKHGQ MN Leukotriene B4 receptor 1 (LTB4R) DMSKHGQ MT DTT DMSKHGQ MA Inhibitor DMSKHGQ RN Synthesis and pharmacological activity of SC-53228, a leukotriene B4 receptor antagonist with high intrinsic potency and selectivity, Bioorg. Med. Chem. Lett. 4(6):811-816 (1994). DMSKHGQ RU http://www.sciencedirect.com/science/article/pii/S0960894X01808532 DM25MUA DI DM25MUA DM25MUA DN SC-56525 DM25MUA MI TTB2MXP DM25MUA MN Angiotensinogenase renin (REN) DM25MUA MT DTT DM25MUA MA Inhibitor DM25MUA RN Effects of SC-56525, a potent, orally active renin inhibitor, in salt-depleted and renal hypertensive dogs. Hypertension. 1995 Jul;26(1):95-100. DM25MUA RU https://pubmed.ncbi.nlm.nih.gov/7607739 DM874YU DI DM874YU DM874YU DN SC-58125 DM874YU MI TTVKILB DM874YU MN Prostaglandin G/H synthase 2 (COX-2) DM874YU MT DTT DM874YU MA Inhibitor DM874YU RN Identification and optimisation of a novel series of pyrimidine based cyclooxygenase-2 (COX-2) inhibitors. Utilisation of a biotransformation appro... Bioorg Med Chem Lett. 2009 Aug 1;19(15):4509-14. DM874YU RU https://pubmed.ncbi.nlm.nih.gov/19523822 DMVGK24 DI DMVGK24 DMVGK24 DN SC-58451 DMVGK24 MI TT8NGED DMVGK24 MN Prostaglandin G/H synthase 1 (COX-1) DMVGK24 MT DTT DMVGK24 MA Inhibitor DMVGK24 RN Novel 1,2-diarylcyclobutenes: Selective and orally active cox-2 inhibitors, Bioorg. Med. Chem. Lett. 6(22):2677-2682 (1996). DMVGK24 RU http://www.sciencedirect.com/science/article/pii/S0960894X9600501X DMVGK24 DI DMVGK24 DMVGK24 DN SC-58451 DMVGK24 MI TTVKILB DMVGK24 MN Prostaglandin G/H synthase 2 (COX-2) DMVGK24 MT DTT DMVGK24 MA Inhibitor DMVGK24 RN Novel 1,2-diarylcyclobutenes: Selective and orally active cox-2 inhibitors, Bioorg. Med. Chem. Lett. 6(22):2677-2682 (1996). DMVGK24 RU http://www.sciencedirect.com/science/article/pii/S0960894X9600501X DMW9H4A DI DMW9H4A DMW9H4A DN SCH 50911 DMW9H4A MI TTDCVZW DMW9H4A MN Gamma-aminobutyric acid B receptor (GABBR) DMW9H4A MT DTT DMW9H4A MA Antagonist DMW9H4A RN Activation of nigral dopamine neurons by the selective GABA(B)-receptor antagonist SCH 50911. J Neural Transm. 1999;106(5-6):383-94. DMW9H4A RU https://pubmed.ncbi.nlm.nih.gov/10443545 DM037SB DI DM037SB DM037SB DN Sch-207758 DM037SB MI TT7WZIJ DM037SB MN CAAX farnesyltransferase beta (FNTB) DM037SB MT DTT DM037SB MA Inhibitor DM037SB RN Exploring the role of bromine at C(10) of (+)-4-[2-[4-(8-chloro-3,10-dibromo- 6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11(R)-yl)-1-piperidinyl]-2- oxoethyl]-1-piperidinecarboxamide (Sch-66336): the discovery of indolocycloheptapyridine inhibitors of farnesyl protein transferase. J Med Chem. 2002 Aug 29;45(18):3854-64. DM037SB RU https://pubmed.ncbi.nlm.nih.gov/12190309 DMXBJCY DI DMXBJCY DMXBJCY DN Sch-40120 DMXBJCY MI TT2J34L DMXBJCY MN Arachidonate 5-lipoxygenase (5-LOX) DMXBJCY MT DTT DMXBJCY MA Modulator DMXBJCY RN Actions of a 5-lipoxygenase inhibitor, Sch 40120, on acute inflammatory responses. J Pharmacol Exp Ther. 1992 Aug;262(2):721-8. DMXBJCY RU https://pubmed.ncbi.nlm.nih.gov/1386887 DM3G5IB DI DM3G5IB DM3G5IB DN Sch-40338 DM3G5IB MI TTQL5VC DM3G5IB MN Platelet-activating factor receptor (PTAFR) DM3G5IB MT DTT DM3G5IB MA Modulator DM3G5IB RN Conformational considerations in the design of dual antagonists of platelet-activating factor (PAF) and histamine. Bioorg Med Chem. 1999 Jul;7(7):1413-23. DM3G5IB RU https://www.ncbi.nlm.nih.gov/pubmed/10465415 DMUL4VX DI DMUL4VX DMUL4VX DN SCH-44342 DMUL4VX MI TT7WZIJ DMUL4VX MN CAAX farnesyltransferase beta (FNTB) DMUL4VX MT DTT DMUL4VX MA Inhibitor DMUL4VX RN Ras farnesyltransferase: a new therapeutic target. J Med Chem. 1997 Sep 12;40(19):2971-90. DMUL4VX RU https://pubmed.ncbi.nlm.nih.gov/9301658 DMUL4VX DI DMUL4VX DMUL4VX DN SCH-44342 DMUL4VX MI TTXQKM3 DMUL4VX MN Farnesyl protein transferase (Ftase) DMUL4VX MT DTT DMUL4VX MA Inhibitor DMUL4VX RN Tricyclic farnesyl protein transferase inhibitors: crystallographic and calorimetric studies of structure-activity relationships. J Med Chem. 1999 Jun 17;42(12):2125-35. DMUL4VX RU https://pubmed.ncbi.nlm.nih.gov/10377218 DME9Q3V DI DME9Q3V DME9Q3V DN Sch-45752 DME9Q3V MI TTL53M6 DME9Q3V MN Induced myeloid leukemia cell differentiation protein Mcl-1 (MCL1) DME9Q3V MT DTT DME9Q3V MA Inhibitor DME9Q3V RN In silico identification and biochemical evaluation of novel inhibitors of NRH:quinone oxidoreductase 2 (NQO2). Bioorg Med Chem Lett. 2010 Dec 15;20(24):7331-6. DME9Q3V RU https://pubmed.ncbi.nlm.nih.gov/21074425 DME9Q3V DI DME9Q3V DME9Q3V DN Sch-45752 DME9Q3V MI TTUST1O DME9Q3V MN Phosphodiesterase (PDE) DME9Q3V MT DTT DME9Q3V MA Inhibitor DME9Q3V RN SCH 45752--an inhibitor of calmodulin-sensitive cyclic nucleotide phosphodiesterase activity. J Antibiot (Tokyo). 1993 Feb;46(2):207-13. DME9Q3V RU https://pubmed.ncbi.nlm.nih.gov/8385657 DMEWLZ7 DI DMEWLZ7 DMEWLZ7 DN SCH-54470 DMEWLZ7 MI TTL69WB DMEWLZ7 MN Angiotensin-converting enzyme (ACE) DMEWLZ7 MT DTT DMEWLZ7 MA Inhibitor DMEWLZ7 RN Phosphinic tripeptides as dual angiotensin-converting enzyme C-domain and endothelin-converting enzyme-1 inhibitors. J Med Chem. 2010 Jan 14;53(1):208-20. DMEWLZ7 RU https://pubmed.ncbi.nlm.nih.gov/19899765 DMEWLZ7 DI DMEWLZ7 DMEWLZ7 DN SCH-54470 DMEWLZ7 MI TTQ9RYT DMEWLZ7 MN Endothelin-converting enzyme 1 (ECE1) DMEWLZ7 MT DTT DMEWLZ7 MA Inhibitor DMEWLZ7 RN Phosphinic tripeptides as dual angiotensin-converting enzyme C-domain and endothelin-converting enzyme-1 inhibitors. J Med Chem. 2010 Jan 14;53(1):208-20. DMEWLZ7 RU https://pubmed.ncbi.nlm.nih.gov/19899765 DMEWLZ7 DI DMEWLZ7 DMEWLZ7 DN SCH-54470 DMEWLZ7 MI TT5TKPM DMEWLZ7 MN Neutral endopeptidase (MME) DMEWLZ7 MT DTT DMEWLZ7 MA Inhibitor DMEWLZ7 RN Phosphinic tripeptides as dual angiotensin-converting enzyme C-domain and endothelin-converting enzyme-1 inhibitors. J Med Chem. 2010 Jan 14;53(1):208-20. DMEWLZ7 RU https://pubmed.ncbi.nlm.nih.gov/19899765 DMGCYPE DI DMGCYPE DMGCYPE DN Sch-57790 DMGCYPE MI TTYEG6Q DMGCYPE MN Muscarinic acetylcholine receptor M2 (CHRM2) DMGCYPE MT DTT DMGCYPE MA Antagonist DMGCYPE RN SCH 57790: a novel M2 receptor selective antagonist. Life Sci. 1999;64(6-7):535-9. DMGCYPE RU https://pubmed.ncbi.nlm.nih.gov/10069520 DMFZNUA DI DMFZNUA DMFZNUA DN SCR-44001 DMFZNUA MI TTHBTOP DMFZNUA MN PI3-kinase gamma (PIK3CG) DMFZNUA MT DTT DMFZNUA MA Inhibitor DMFZNUA RN Early detection of response to experimental chemotherapeutic Top216 with [18F]FLT and [18F]FDG PET in human ovary cancer xenografts in mice. PLoS One. 2010 Sep 24;5(9):e12965. DMFZNUA RU https://pubmed.ncbi.nlm.nih.gov/20885974 DMFZNUA DI DMFZNUA DMFZNUA DN SCR-44001 DMFZNUA MI TTCJG29 DMFZNUA MN Serine/threonine-protein kinase mTOR (mTOR) DMFZNUA MT DTT DMFZNUA MA Inhibitor DMFZNUA RN Early detection of response to experimental chemotherapeutic Top216 with [18F]FLT and [18F]FDG PET in human ovary cancer xenografts in mice. PLoS One. 2010 Sep 24;5(9):e12965. DMFZNUA RU https://pubmed.ncbi.nlm.nih.gov/20885974 DMPUVFH DI DMPUVFH DMPUVFH DN SDZ 216-525 DMPUVFH MI TTSQIFT DMPUVFH MN 5-HT 1A receptor (HTR1A) DMPUVFH MT DTT DMPUVFH MA Antagonist DMPUVFH RN Influence of 5-HT1A receptor antagonism on plus-maze behaviour in mice. II. WAY 100635, SDZ 216-525 and NAN-190. Pharmacol Biochem Behav. 1997 Oct;58(2):593-603. DMPUVFH RU https://pubmed.ncbi.nlm.nih.gov/9300624 DMY1KE8 DI DMY1KE8 DMY1KE8 DN SDZ-224-015 DMY1KE8 MI TTCQIBE DMY1KE8 MN Caspase-1 (CASP1) DMY1KE8 MT DTT DMY1KE8 MA Modulator DMY1KE8 RN Reduction of inflammation and pyrexia in the rat by oral administration of SDZ 224-015, an inhibitor of the interleukin-1 beta converting enzyme. Br J Pharmacol. 1995 Jun;115(4):601-6. DMY1KE8 RU https://pubmed.ncbi.nlm.nih.gov/7582478 DMPZLKC DI DMPZLKC DMPZLKC DN SDZ-249482 DMPZLKC MI TT5HONZ DMPZLKC MN Calcium channel unspecific (CaC) DMPZLKC MT DTT DMPZLKC MA Modulator DMPZLKC RN Physiology and Pharmacology of the Vanilloid Receptor. Curr Neuropharmacol. 2006 January; 4(1): 1-15. DMPZLKC RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2430674/ DMAT657 DI DMAT657 DMAT657 DN SDZ-62-826 DMAT657 MI TT6MP2Z DMAT657 MN GMCSFR-alpha (CSF2RA) DMAT657 MT DTT DMAT657 MA Modulator DMAT657 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1707). DMAT657 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1707 DM2CBTU DI DM2CBTU DM2CBTU DN SDZ-64-412 DM2CBTU MI TTQL5VC DM2CBTU MN Platelet-activating factor receptor (PTAFR) DM2CBTU MT DTT DM2CBTU MA Inhibitor DM2CBTU RN Structural modification of 5-aryl-2,3-dihydroimidazo[2,1-a]isoquinoline platelet activating factor receptor antagonists. J Med Chem. 1993 Oct 15;36(21):3098-102. DM2CBTU RU https://pubmed.ncbi.nlm.nih.gov/8230095 DMBY6CQ DI DMBY6CQ DMBY6CQ DN SDZ-87-469 DMBY6CQ MI TTE14XG DMBY6CQ MN Squalene monooxygenase (SQLE) DMBY6CQ MT DTT DMBY6CQ MA Modulator DMBY6CQ RN Effects of squalene epoxidase inhibitors on Candida albicans. Antimicrob Agents Chemother. 1992 Aug;36(8):1779-81. DMBY6CQ RU https://pubmed.ncbi.nlm.nih.gov/1416865 DMN5IY7 DI DMN5IY7 DMN5IY7 DN SDZ-ICM-567 DMN5IY7 MI TTNXLKE DMN5IY7 MN 5-HT 3 receptor (5HT3R) DMN5IY7 MT DTT DMN5IY7 MA Antagonist DMN5IY7 RN Microdialysis sampling to determine the pharmacokinetics of unbound SDZ ICM 567 in blood and brain in awake, freely-moving rats. Pharm Res. 1995 Feb;12(2):291-4. DMN5IY7 RU https://pubmed.ncbi.nlm.nih.gov/7784347 DMSZJUM DI DMSZJUM DMSZJUM DN SDZ-ISQ-844 DMSZJUM MI TTZCG4L DMSZJUM MN Phosphodiesterase 3 (PDE3) DMSZJUM MT DTT DMSZJUM MA Modulator DMSZJUM RN [Effects of SDZ ISQ 844, a cyclic nucleotide phosphodiesterase isozyme type III/IV inhibitor, on the release of histamine from human peripheral leukocytes].Arerugi.1997 May;46(5):426-32. DMSZJUM RU https://www.ncbi.nlm.nih.gov/pubmed/9232912 DMKCXBJ DI DMKCXBJ DMKCXBJ DN SDZ-MTH-958 DMKCXBJ MI TTEMV5X DMKCXBJ MN Serine protease unspecific (SP) DMKCXBJ MT DTT DMKCXBJ MA Modulator DMKCXBJ RN Thrombin inhibition in an ex vivo model of porcine heart xenograft hyperacute rejection. Transplantation. 1996 Mar 27;61(6):862-8. DMKCXBJ RU https://pubmed.ncbi.nlm.nih.gov/8623150 DM48MCL DI DM48MCL DM48MCL DN SDZ-PSD-958 DM48MCL MI TTZFYLI DM48MCL MN Dopamine D1 receptor (D1R) DM48MCL MT DTT DM48MCL MA Modulator DM48MCL RN SDZ PSD 958, a novel D1 receptor antagonist with potential limbic selectivity. J Neural Transm. 1996;103(3):261-76. DM48MCL RU https://pubmed.ncbi.nlm.nih.gov/8739838 DMXHW91 DI DMXHW91 DMXHW91 DN SDZ-SER-082 DMXHW91 MI TTWJBZ5 DMXHW91 MN 5-HT 2C receptor (HTR2C) DMXHW91 MT DTT DMXHW91 MA Modulator DMXHW91 RN Effect of the activation of central 5-HT2C receptors by the 5-HT2C agonist mCPP on blood pressure and heart rate in rats. Brain Res. 2005 Apr 8;1040(1-2):64-72. DMXHW91 RU https://www.ncbi.nlm.nih.gov/pubmed/15804427 DM4ESAP DI DM4ESAP DM4ESAP DN Selenotifen DM4ESAP MI TTTIBOJ DM4ESAP MN Histamine H1 receptor (H1R) DM4ESAP MT DTT DM4ESAP MA Modulator DM4ESAP RN Effect of BN 52256 and other mediator antagonists on ouabain-induced cardiac arrhythmia in a model of anaphylaxis in guinea-pigs. Pharmacol Res. 1992 Feb-Mar;25(2):173-80. DM4ESAP RU https://pubmed.ncbi.nlm.nih.gov/1635894 DMXRU72 DI DMXRU72 DMXRU72 DN SEP-227900 DMXRU72 MI TT7Y3EJ DMXRU72 MN D-amino acid oxidase (DAO) DMXRU72 MT DTT DMXRU72 MA Inhibitor DMXRU72 RN The Therapeutic Potential of D-Amino Acid Oxidase (DAAO) Inhibitors. Open Med Chem J. 2010; 4: 3-9. DMXRU72 RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2905773/ DMTBWU1 DI DMTBWU1 DMTBWU1 DN Seridopidine DMTBWU1 MI TTVBI8W DMTBWU1 MN Dopamine transporter (DAT) DMTBWU1 MT DTT DMTBWU1 MA Modulator DMTBWU1 RN Pridopidine selectively occupies sigma-1 rather than dopamine D2 receptors at behaviorally active doses. Psychopharmacology (Berl). 2015 Sep;232(18):3443-53. DMTBWU1 RU https://pubmed.ncbi.nlm.nih.gov/26159455 DMT43AI DI DMT43AI DMT43AI DN SIB-1508Y DMT43AI MI TTL1ATN DMT43AI MN Neuronal acetylcholine receptor alpha-4/beta-2 (CHRNA4/B2) DMT43AI MT DTT DMT43AI MA Modulator DMT43AI RN Nicotinic Receptors in Neurodegeneration DMT43AI RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3648781 DMO4WB8 DI DMO4WB8 DMO4WB8 DN SIB-1663 DMO4WB8 MI TTJSZTB DMO4WB8 MN Nicotinic acetylcholine receptor (nAChR) DMO4WB8 MT DTT DMO4WB8 MA Agonist DMO4WB8 RN The therapeutic potential of nicotinic acetylcholine receptor agonists for pain control. Expert Opin Investig Drugs. 2001 Oct;10(10):1819-30. DMO4WB8 RU https://pubmed.ncbi.nlm.nih.gov/11772288 DM6MSKT DI DM6MSKT DM6MSKT DN SIB-1765F DM6MSKT MI TTJSZTB DM6MSKT MN Nicotinic acetylcholine receptor (nAChR) DM6MSKT MT DTT DM6MSKT MA Agonist DM6MSKT RN Interactions between a novel cholinergic ion channel agonist, SIB-1765F and L-DOPA in the reserpine model of Parkinson's disease in rats. J Pharmacol Exp Ther. 1997 Jan;280(1):393-401. DM6MSKT RU https://pubmed.ncbi.nlm.nih.gov/8996220 DM98K76 DI DM98K76 DM98K76 DN Siguazodan DM98K76 MI TTZCG4L DM98K76 MN Phosphodiesterase 3 (PDE3) DM98K76 MT DTT DM98K76 MA Modulator DM98K76 RN Cyclic-AMP-dependent proliferation of a human osteoblast cell line (HOS cells) induced by hydroxyapatite: effect of exogenous nitric oxide. Acta Biomed. 2008 Aug;79(2):110-6. DM98K76 RU https://www.ncbi.nlm.nih.gov/pubmed/18788505 DMBZ7SF DI DMBZ7SF DMBZ7SF DN SIM-6080 DMBZ7SF MI TT5HONZ DMBZ7SF MN Calcium channel unspecific (CaC) DMBZ7SF MT DTT DMBZ7SF MA Blocker DMBZ7SF RN Determination of the calcium antagonist SIM6080 and its N- and O-demethylated metabolites in plasma, urine and tissues by high-performance liquid chromatography. J Chromatogr B Biomed Appl. 1996 Feb 9;676(1):77-85. DMBZ7SF RU https://pubmed.ncbi.nlm.nih.gov/8852047 DM5SBUJ DI DM5SBUJ DM5SBUJ DN Sipoglitazar DM5SBUJ MI TTJ584C DM5SBUJ MN Peroxisome proliferator-activated receptor alpha (PPARA) DM5SBUJ MT DTT DM5SBUJ MA Modulator DM5SBUJ RN Pharmacokinetics, safety, and tolerability of saroglitazar (ZYH1), a predominantly PPARalpha agonist with moderate PPARgamma agonist activity in healthy human subjects. Clin Drug Investig. 2013 Nov;33(11):809-16. DM5SBUJ RU https://pubmed.ncbi.nlm.nih.gov/24062180 DM5SBUJ DI DM5SBUJ DM5SBUJ DN Sipoglitazar DM5SBUJ MI TTZMAO3 DM5SBUJ MN Peroxisome proliferator-activated receptor gamma (PPAR-gamma) DM5SBUJ MT DTT DM5SBUJ MA Modulator DM5SBUJ RN Pharmacokinetics, safety, and tolerability of saroglitazar (ZYH1), a predominantly PPARalpha agonist with moderate PPARgamma agonist activity in healthy human subjects. Clin Drug Investig. 2013 Nov;33(11):809-16. DM5SBUJ RU https://pubmed.ncbi.nlm.nih.gov/24062180 DMB6T7K DI DMB6T7K DMB6T7K DN Siramesine DMB6T7K MI TTNGILX DMB6T7K MN Adrenergic receptor alpha-1A (ADRA1A) DMB6T7K MT DTT DMB6T7K MA Inhibitor DMB6T7K RN Sigma ligands with subnanomolar affinity and preference for the sigma 2 binding site. 1. 3-(omega-aminoalkyl)-1H-indoles. J Med Chem. 1995 May 26;38(11):1998-2008. DMB6T7K RU https://pubmed.ncbi.nlm.nih.gov/7783131 DMB6T7K DI DMB6T7K DMB6T7K DN Siramesine DMB6T7K MI TTBRKXS DMB6T7K MN Adrenergic receptor alpha-1B (ADRA1B) DMB6T7K MT DTT DMB6T7K MA Inhibitor DMB6T7K RN Sigma ligands with subnanomolar affinity and preference for the sigma 2 binding site. 1. 3-(omega-aminoalkyl)-1H-indoles. J Med Chem. 1995 May 26;38(11):1998-2008. DMB6T7K RU https://pubmed.ncbi.nlm.nih.gov/7783131 DMB6T7K DI DMB6T7K DMB6T7K DN Siramesine DMB6T7K MI TT34BHT DMB6T7K MN Adrenergic receptor alpha-1D (ADRA1D) DMB6T7K MT DTT DMB6T7K MA Inhibitor DMB6T7K RN Sigma ligands with subnanomolar affinity and preference for the sigma 2 binding site. 1. 3-(omega-aminoalkyl)-1H-indoles. J Med Chem. 1995 May 26;38(11):1998-2008. DMB6T7K RU https://pubmed.ncbi.nlm.nih.gov/7783131 DMG90YW DI DMG90YW DMG90YW DN Siratiazem DMG90YW MI TT5HONZ DMG90YW MN Calcium channel unspecific (CaC) DMG90YW MT DTT DMG90YW MA Modulator DMG90YW RN Comparison of the effects of diltiazem and its analogue siratiazem on contractility in arteries, ileum and cardiac muscle. J Auton Pharmacol. 1995 Apr;15(2):107-13. DMG90YW RU https://pubmed.ncbi.nlm.nih.gov/7615573 DM6X430 DI DM6X430 DM6X430 DN SJA-6017 DM6X430 MI TTG5QB7 DM6X430 MN Calpain-2 (CAPN2) DM6X430 MT DTT DM6X430 MA Inhibitor DM6X430 RN Synthesis, biological evaluation and molecular modelling of N-heterocyclic dipeptide aldehydes as selective calpain inhibitors. Bioorg Med Chem. 2008 Jul 15;16(14):6911-23. DM6X430 RU https://pubmed.ncbi.nlm.nih.gov/18571418 DMRADBU DI DMRADBU DMRADBU DN SK&F-104078 DMRADBU MI TTNGILX DMRADBU MN Adrenergic receptor alpha-1A (ADRA1A) DMRADBU MT DTT DMRADBU MA Inhibitor DMRADBU RN Alpha- and beta-adrenoceptors: from the gene to the clinic. 2. Structure-activity relationships and therapeutic applications. J Med Chem. 1995 Sep 15;38(19):3681-716. DMRADBU RU https://pubmed.ncbi.nlm.nih.gov/7562902 DMRADBU DI DMRADBU DMRADBU DN SK&F-104078 DMRADBU MI TTBRKXS DMRADBU MN Adrenergic receptor alpha-1B (ADRA1B) DMRADBU MT DTT DMRADBU MA Inhibitor DMRADBU RN Alpha- and beta-adrenoceptors: from the gene to the clinic. 2. Structure-activity relationships and therapeutic applications. J Med Chem. 1995 Sep 15;38(19):3681-716. DMRADBU RU https://pubmed.ncbi.nlm.nih.gov/7562902 DMRADBU DI DMRADBU DMRADBU DN SK&F-104078 DMRADBU MI TT34BHT DMRADBU MN Adrenergic receptor alpha-1D (ADRA1D) DMRADBU MT DTT DMRADBU MA Inhibitor DMRADBU RN Alpha- and beta-adrenoceptors: from the gene to the clinic. 2. Structure-activity relationships and therapeutic applications. J Med Chem. 1995 Sep 15;38(19):3681-716. DMRADBU RU https://pubmed.ncbi.nlm.nih.gov/7562902 DMRADBU DI DMRADBU DMRADBU DN SK&F-104078 DMRADBU MI TTWG9A4 DMRADBU MN Adrenergic receptor alpha-2A (ADRA2A) DMRADBU MT DTT DMRADBU MA Inhibitor DMRADBU RN Alpha- and beta-adrenoceptors: from the gene to the clinic. 1. Molecular biology and adrenoceptor subclassification. J Med Chem. 1995 Sep 1;38(18):3415-44. DMRADBU RU https://pubmed.ncbi.nlm.nih.gov/7658428 DMRADBU DI DMRADBU DMRADBU DN SK&F-104078 DMRADBU MI TTWM4TY DMRADBU MN Adrenergic receptor alpha-2B (ADRA2B) DMRADBU MT DTT DMRADBU MA Inhibitor DMRADBU RN Alpha- and beta-adrenoceptors: from the gene to the clinic. 1. Molecular biology and adrenoceptor subclassification. J Med Chem. 1995 Sep 1;38(18):3415-44. DMRADBU RU https://pubmed.ncbi.nlm.nih.gov/7658428 DMRADBU DI DMRADBU DMRADBU DN SK&F-104078 DMRADBU MI TT2NUT5 DMRADBU MN Adrenergic receptor alpha-2C (ADRA2C) DMRADBU MT DTT DMRADBU MA Inhibitor DMRADBU RN Alpha- and beta-adrenoceptors: from the gene to the clinic. 1. Molecular biology and adrenoceptor subclassification. J Med Chem. 1995 Sep 1;38(18):3415-44. DMRADBU RU https://pubmed.ncbi.nlm.nih.gov/7658428 DMN91EK DI DMN91EK DMN91EK DN SK&F-104856 DMN91EK MI TTNGILX DMN91EK MN Adrenergic receptor alpha-1A (ADRA1A) DMN91EK MT DTT DMN91EK MA Inhibitor DMN91EK RN Alpha- and beta-adrenoceptors: from the gene to the clinic. 2. Structure-activity relationships and therapeutic applications. J Med Chem. 1995 Sep 15;38(19):3681-716. DMN91EK RU https://pubmed.ncbi.nlm.nih.gov/7562902 DMN91EK DI DMN91EK DMN91EK DN SK&F-104856 DMN91EK MI TTBRKXS DMN91EK MN Adrenergic receptor alpha-1B (ADRA1B) DMN91EK MT DTT DMN91EK MA Inhibitor DMN91EK RN Alpha- and beta-adrenoceptors: from the gene to the clinic. 2. Structure-activity relationships and therapeutic applications. J Med Chem. 1995 Sep 15;38(19):3681-716. DMN91EK RU https://pubmed.ncbi.nlm.nih.gov/7562902 DMN91EK DI DMN91EK DMN91EK DN SK&F-104856 DMN91EK MI TT34BHT DMN91EK MN Adrenergic receptor alpha-1D (ADRA1D) DMN91EK MT DTT DMN91EK MA Inhibitor DMN91EK RN Alpha- and beta-adrenoceptors: from the gene to the clinic. 2. Structure-activity relationships and therapeutic applications. J Med Chem. 1995 Sep 15;38(19):3681-716. DMN91EK RU https://pubmed.ncbi.nlm.nih.gov/7562902 DMRM7H0 DI DMRM7H0 DMRM7H0 DN SK&F-95601 DMRM7H0 MI TTLOKXP DMRM7H0 MN Gastric H(+)/K(+) ATPase (Proton pump) DMRM7H0 MT DTT DMRM7H0 MA Modulator DMRM7H0 RN 2-[[(4-Amino-2-pyridyl)methyl]sulfinyl]benzimidazole H+/K+-ATPase inhibitors.The relationship between pyridine basicity, stability, and activity.J Med Chem.1989 Aug;32(8):1970-7. DMRM7H0 RU https://www.ncbi.nlm.nih.gov/pubmed/2547073 DM6RVXU DI DM6RVXU DM6RVXU DN SK-951 DM6RVXU MI TT07C3Y DM6RVXU MN 5-HT 4 receptor (HTR4) DM6RVXU MT DTT DM6RVXU MA Agonist DM6RVXU RN Identification of SK-951, a novel benzofuran derivative, as an agonist to 5-HT4 receptors. Jpn J Pharmacol. 1999 Feb;79(2):203-12. DM6RVXU RU https://pubmed.ncbi.nlm.nih.gov/10202856 DMIMJ8Z DI DMIMJ8Z DMIMJ8Z DN SKF 38393 DMIMJ8Z MI TTZFYLI DMIMJ8Z MN Dopamine D1 receptor (D1R) DMIMJ8Z MT DTT DMIMJ8Z MA Modulator DMIMJ8Z RN The D1 dopamine receptor agonist SKF-38393 stimulates the release of glutamate in the hippocampus. Neuroscience. 1999;94(4):1063-70. DMIMJ8Z RU https://pubmed.ncbi.nlm.nih.gov/10625048 DM8MWFZ DI DM8MWFZ DM8MWFZ DN SKF-104351 DM8MWFZ MI TT2J34L DM8MWFZ MN Arachidonate 5-lipoxygenase (5-LOX) DM8MWFZ MT DTT DM8MWFZ MA Modulator DM8MWFZ RN WO patent application no. 2006,1317,37, Method and composition for treating inflammatory disorders. DM8MWFZ RU http://www.google.com/patents/WO2006131737A2?cl=en DM7QPYK DI DM7QPYK DM7QPYK DN SKF-106760 DM7QPYK MI TT38RM1 DM7QPYK MN Glycoprotein IIb/IIIa receptor (GPIIb/IIIa) DM7QPYK MT DTT DM7QPYK MA Modulator DM7QPYK RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. DM7QPYK RU https://www.fda.gov/ DMM8F0V DI DMM8F0V DMM8F0V DN SKF-107260 DMM8F0V MI TTJA1ZO DMM8F0V MN ITGB3 messenger RNA (ITGB3 mRNA) DMM8F0V MT DTT DMM8F0V MA Inhibitor DMM8F0V RN Preparation and Properties of a fibrinogen receptor antagonist containing the Arg-Gly-Asp sequence and nitroxide radicals, Bioorg. Med. Chem. Lett. 3(6):1179-1184 (1993). DMM8F0V RU http://www.sciencedirect.com/science/article/pii/S0960894X00803108 DM4LGPT DI DM4LGPT DM4LGPT DN SKF-81297 DM4LGPT MI TTZFYLI DM4LGPT MN Dopamine D1 receptor (D1R) DM4LGPT MT DTT DM4LGPT MA Modulator DM4LGPT RN Dopamine D1 receptor involvement in the discriminative-stimulus effects of SKF 81297 in squirrel monkeys. J Pharmacol Exp Ther. 1993 Nov;267(2):765-75. DM4LGPT RU https://pubmed.ncbi.nlm.nih.gov/7902432 DMS2M58 DI DMS2M58 DMS2M58 DN SKF-96231 DMS2M58 MI TTJ0IQB DMS2M58 MN Phosphodiesterase 5A (PDE5A) DMS2M58 MT DTT DMS2M58 MA Inhibitor DMS2M58 RN Analogue-based Drug Discovery II. Janos Fischer,C. Robin Ganellin. Page(150). DMS2M58 RU https://books.google.com.hk/books?id=h2Kd8ci4Ln8C&pg=PA150&lpg=PA150&dq=SKF-96231++++++++++++++PDE+5&source=bl&ots=yRj1Q8yHYq&sig=60AYTs3Vk3T_KDV-F7MHenbl4T4&hl=zh-CN&sa=X&ved=0CB8Q6AEwAGoVChMIhvKspOq5yAIVCXKOCh3MhAmi#v=onepage&q=SKF-96231%20%20%20%20%20%20%20%20%20%20%20%20%20%20PDE%205&f=false DMI79JN DI DMI79JN DMI79JN DN SKF-96365 DMI79JN MI TT5HONZ DMI79JN MN Calcium channel unspecific (CaC) DMI79JN MT DTT DMI79JN MA Modulator DMI79JN RN The transient receptor potential channel antagonist SKF96365 is a potent blocker of low-voltage-activated T-type calcium channels. Br J Pharmacol. 2010 Jul;160(6):1464-75. DMI79JN RU https://pubmed.ncbi.nlm.nih.gov/20590636 DMI1WNF DI DMI1WNF DMI1WNF DN SL-18.1616 DMI1WNF MI TT0WAIE DMI1WNF MN Melatonin receptor type 1A (MTNR1A) DMI1WNF MT DTT DMI1WNF MA Agonist DMI1WNF RN US patent application no. 2005,016,4987, Melatonin combination therapy for improving sleep quality. DMI1WNF RU http://www.google.com/patents/US20050164987 DMJ9RLX DI DMJ9RLX DMJ9RLX DN SL-91.0893 DMJ9RLX MI TT34BHT DMJ9RLX MN Adrenergic receptor alpha-1D (ADRA1D) DMJ9RLX MT DTT DMJ9RLX MA Modulator DMJ9RLX RN Tissue Selectivity of in vivo alpha1-Adrenoceptor Biding of KMD-3213 in Rats. Eur Urol 1999;36(suppl 1):113-117. DMJ9RLX RU https://www.karger.com/Article/Pdf/52331 DMNTGXQ DI DMNTGXQ DMNTGXQ DN SL-910102 DMNTGXQ MI TTGN1ZA DMNTGXQ MN Angiotensin II receptor (AGTR) DMNTGXQ MT DTT DMNTGXQ MA Modulator DMNTGXQ RN A radioreceptor assay for the analysis of AT1-receptor antagonists. Correlation with complementary LC data reveals a potential contribution of active metabolites. J Pharm Biomed Anal. 1998 May;17(1):111-24. DMNTGXQ RU https://pubmed.ncbi.nlm.nih.gov/9608433 DMCPDBS DI DMCPDBS DMCPDBS DN SLV-307 DMCPDBS MI TTSQIFT DMCPDBS MN 5-HT 1A receptor (HTR1A) DMCPDBS MT DTT DMCPDBS MA Antagonist DMCPDBS RN Development and validation of a capillary electrophoresis method for the enantiomeric purity determination of SLV307, a basic potential antipsychotic compound. Electrophoresis. 2004 Aug;25(16):2854-9. DMCPDBS RU https://pubmed.ncbi.nlm.nih.gov/15352019 DMCPDBS DI DMCPDBS DMCPDBS DN SLV-307 DMCPDBS MI TTEX248 DMCPDBS MN Dopamine D2 receptor (D2R) DMCPDBS MT DTT DMCPDBS MA Antagonist DMCPDBS RN Development and validation of a capillary electrophoresis method for the enantiomeric purity determination of SLV307, a basic potential antipsychotic compound. Electrophoresis. 2004 Aug;25(16):2854-9. DMCPDBS RU https://pubmed.ncbi.nlm.nih.gov/15352019 DMF0QMD DI DMF0QMD DMF0QMD DN SM 11044 DMF0QMD MI TTMXGCW DMF0QMD MN Adrenergic receptor beta-3 (ADRB3) DMF0QMD MT DTT DMF0QMD MA Agonist DMF0QMD RN Effects of several putative beta 3-adrenoceptor agonists on lipolysis in human omental adipocytes. Int J Obes Relat Metab Disord. 1996 May;20(5):428-34. DMF0QMD RU https://pubmed.ncbi.nlm.nih.gov/8696421 DMHXJV2 DI DMHXJV2 DMHXJV2 DN SM-16 DMHXJV2 MI TTP4520 DMHXJV2 MN TGF-beta receptor type I (TGFBR1) DMHXJV2 MT DTT DMHXJV2 MA Inhibitor DMHXJV2 RN TGF-beta type I receptor kinase inhibitor down-regulates rheumatoid synoviocytes and prevents the arthritis induced by type II collagen antibody. Int Immunol. 2007 Feb;19(2):117-26. DMHXJV2 RU https://pubmed.ncbi.nlm.nih.gov/17135447 DMNX93E DI DMNX93E DMNX93E DN SM-19712 DMNX93E MI TT1BGDH DMNX93E MN Endothelin-converting enzyme (ECE) DMNX93E MT DTT DMNX93E MA Inhibitor DMNX93E RN Protective effect of SM-19712, a novel and potent endothelin converting enzyme inhibitor, on ischemic acute renal failure in rats. Jpn J Pharmacol. 2000 Sep;84(1):16-24. DMNX93E RU https://pubmed.ncbi.nlm.nih.gov/11043448 DMROJEN DI DMROJEN DMROJEN DN SNAP-5089 DMROJEN MI TTNGILX DMROJEN MN Adrenergic receptor alpha-1A (ADRA1A) DMROJEN MT DTT DMROJEN MA Inhibitor DMROJEN RN Alpha- and beta-adrenoceptors: from the gene to the clinic. 2. Structure-activity relationships and therapeutic applications. J Med Chem. 1995 Sep 15;38(19):3681-716. DMROJEN RU https://pubmed.ncbi.nlm.nih.gov/7562902 DMROJEN DI DMROJEN DMROJEN DN SNAP-5089 DMROJEN MI TTBRKXS DMROJEN MN Adrenergic receptor alpha-1B (ADRA1B) DMROJEN MT DTT DMROJEN MA Inhibitor DMROJEN RN Alpha- and beta-adrenoceptors: from the gene to the clinic. 2. Structure-activity relationships and therapeutic applications. J Med Chem. 1995 Sep 15;38(19):3681-716. DMROJEN RU https://pubmed.ncbi.nlm.nih.gov/7562902 DMROJEN DI DMROJEN DMROJEN DN SNAP-5089 DMROJEN MI TT34BHT DMROJEN MN Adrenergic receptor alpha-1D (ADRA1D) DMROJEN MT DTT DMROJEN MA Inhibitor DMROJEN RN Alpha- and beta-adrenoceptors: from the gene to the clinic. 2. Structure-activity relationships and therapeutic applications. J Med Chem. 1995 Sep 15;38(19):3681-716. DMROJEN RU https://pubmed.ncbi.nlm.nih.gov/7562902 DMROJEN DI DMROJEN DMROJEN DN SNAP-5089 DMROJEN MI TTWG9A4 DMROJEN MN Adrenergic receptor alpha-2A (ADRA2A) DMROJEN MT DTT DMROJEN MA Inhibitor DMROJEN RN Design and synthesis of novel dihydropyridine alpha-1a antagonists. Bioorg Med Chem Lett. 1999 Oct 4;9(19):2843-8. DMROJEN RU https://pubmed.ncbi.nlm.nih.gov/10522703 DMROJEN DI DMROJEN DMROJEN DN SNAP-5089 DMROJEN MI TTWM4TY DMROJEN MN Adrenergic receptor alpha-2B (ADRA2B) DMROJEN MT DTT DMROJEN MA Inhibitor DMROJEN RN Design and synthesis of novel dihydropyridine alpha-1a antagonists. Bioorg Med Chem Lett. 1999 Oct 4;9(19):2843-8. DMROJEN RU https://pubmed.ncbi.nlm.nih.gov/10522703 DMROJEN DI DMROJEN DMROJEN DN SNAP-5089 DMROJEN MI TT2NUT5 DMROJEN MN Adrenergic receptor alpha-2C (ADRA2C) DMROJEN MT DTT DMROJEN MA Inhibitor DMROJEN RN Design and synthesis of novel dihydropyridine alpha-1a antagonists. Bioorg Med Chem Lett. 1999 Oct 4;9(19):2843-8. DMROJEN RU https://pubmed.ncbi.nlm.nih.gov/10522703 DMROJEN DI DMROJEN DMROJEN DN SNAP-5089 DMROJEN MI TTZIFHC DMROJEN MN Voltage-gated calcium channel alpha Cav1.2 (CACNA1C) DMROJEN MT DTT DMROJEN MA Inhibitor DMROJEN RN Design and synthesis of novel dihydropyridine alpha-1a antagonists. Bioorg Med Chem Lett. 1999 Oct 4;9(19):2843-8. DMROJEN RU https://pubmed.ncbi.nlm.nih.gov/10522703 DMROJEN DI DMROJEN DMROJEN DN SNAP-5089 DMROJEN MI TT7RGTM DMROJEN MN Voltage-gated calcium channel alpha Cav1.3 (CACNA1D) DMROJEN MT DTT DMROJEN MA Inhibitor DMROJEN RN Discovery of alpha 1a-adrenergic receptor antagonists based on the L-type Ca2+ channel antagonist niguldipine. J Med Chem. 1995 May 12;38(10):1579-81. DMROJEN RU https://pubmed.ncbi.nlm.nih.gov/7752182 DMNE4TS DI DMNE4TS DMNE4TS DN SNAP-6201 DMNE4TS MI TTNGILX DMNE4TS MN Adrenergic receptor alpha-1A (ADRA1A) DMNE4TS MT DTT DMNE4TS MA Inhibitor DMNE4TS RN Pharmacophore identification of alpha(1A)-adrenoceptor antagonists. Bioorg Med Chem Lett. 2005 Feb 1;15(3):657-64. DMNE4TS RU https://pubmed.ncbi.nlm.nih.gov/15664832 DM4CNM9 DI DM4CNM9 DM4CNM9 DN SNF-9007 DM4CNM9 MI TTCG0AL DM4CNM9 MN Cholecystokinin receptor type A (CCKAR) DM4CNM9 MT DTT DM4CNM9 MA Inhibitor DM4CNM9 RN Structure-activity relationships of bifunctional peptides based on overlapping pharmacophores at opioid and cholecystokinin receptors. J Med Chem. 2006 May 18;49(10):2868-75. DM4CNM9 RU https://pubmed.ncbi.nlm.nih.gov/16686530 DM4CNM9 DI DM4CNM9 DM4CNM9 DN SNF-9007 DM4CNM9 MI TTVFO0U DM4CNM9 MN Gastrin/cholecystokinin type B receptor (CCKBR) DM4CNM9 MT DTT DM4CNM9 MA Inhibitor DM4CNM9 RN Structure-activity relationships of bifunctional peptides based on overlapping pharmacophores at opioid and cholecystokinin receptors. J Med Chem. 2006 May 18;49(10):2868-75. DM4CNM9 RU https://pubmed.ncbi.nlm.nih.gov/16686530 DM4CNM9 DI DM4CNM9 DM4CNM9 DN SNF-9007 DM4CNM9 MI TT27RFC DM4CNM9 MN Opioid receptor delta (OPRD1) DM4CNM9 MT DTT DM4CNM9 MA Inhibitor DM4CNM9 RN Structure-activity relationships of bifunctional peptides based on overlapping pharmacophores at opioid and cholecystokinin receptors. J Med Chem. 2006 May 18;49(10):2868-75. DM4CNM9 RU https://pubmed.ncbi.nlm.nih.gov/16686530 DM4CNM9 DI DM4CNM9 DM4CNM9 DN SNF-9007 DM4CNM9 MI TTKWM86 DM4CNM9 MN Opioid receptor mu (MOP) DM4CNM9 MT DTT DM4CNM9 MA Inhibitor DM4CNM9 RN Structure-activity relationships of bifunctional peptides based on overlapping pharmacophores at opioid and cholecystokinin receptors. J Med Chem. 2006 May 18;49(10):2868-75. DM4CNM9 RU https://pubmed.ncbi.nlm.nih.gov/16686530 DMFI0GW DI DMFI0GW DMFI0GW DN Sonepiprazole DMFI0GW MI TTE0A2F DMFI0GW MN Dopamine D4 receptor (D4R) DMFI0GW MT DTT DMFI0GW MA Binder DMFI0GW RN The pipeline and future of drug development in schizophrenia. Mol Psychiatry. 2007 Oct;12(10):904-22. DMFI0GW RU https://pubmed.ncbi.nlm.nih.gov/17667958 DM31VE4 DI DM31VE4 DM31VE4 DN Sorbinil DM31VE4 MI TTFBNVI DM31VE4 MN Aldose reductase (AKR1B1) DM31VE4 MT DTT DM31VE4 MA Inhibitor DM31VE4 RN A controlled trial of sorbinil, an aldose reductase inhibitor, in chronic painful diabetic neuropathy. Diabetes. 1983 Oct;32(10):938-42. DM31VE4 RU https://pubmed.ncbi.nlm.nih.gov/6225686 DMTDLHG DI DMTDLHG DMTDLHG DN SORETOLIDE DMTDLHG MI TTVPQTF DMTDLHG MN Glutamate receptor AMPA 1 (GRIA1) DMTDLHG MT DTT DMTDLHG MA Modulator DMTDLHG RN Preclinical pharmacology of perampanel, a selective non-competitive AMPA receptor antagonist. Acta Neurol Scand Suppl. 2013;(197):19-24. DMTDLHG RU https://pubmed.ncbi.nlm.nih.gov/23480152 DM9HFV7 DI DM9HFV7 DM9HFV7 DN SPD-756 DM9HFV7 MI TT84ETX DM9HFV7 MN Human immunodeficiency virus Reverse transcriptase (HIV RT) DM9HFV7 MT DTT DM9HFV7 MA Inhibitor DM9HFV7 RN Single dose pharmacokinetics of SPD-756 in healthy adult volunteers, P F Smith, Poster Exhibition: The XIV International AIDS Conference: Abstract no. WePeB6050. DM9HFV7 RU https://www.aids2014.org/Abstracts/A1704.aspx DMD4BFY DI DMD4BFY DMD4BFY DN Spermine DMD4BFY MI TTUNARX DMD4BFY MN Carbonic anhydrase (CA) DMD4BFY MT DTT DMD4BFY MA Inhibitor DMD4BFY RN Polyamines inhibit carbonic anhydrases by anchoring to the zinc-coordinated water molecule. J Med Chem. 2010 Aug 12;53(15):5511-22. DMD4BFY RU https://pubmed.ncbi.nlm.nih.gov/20590092 DMD4BFY DI DMD4BFY DMD4BFY DN Spermine DMD4BFY MI TTZHA0O DMD4BFY MN Carbonic anhydrase IV (CA-IV) DMD4BFY MT DTT DMD4BFY MA Inhibitor DMD4BFY RN Polyamines inhibit carbonic anhydrases by anchoring to the zinc-coordinated water molecule. J Med Chem. 2010 Aug 12;53(15):5511-22. DMD4BFY RU https://pubmed.ncbi.nlm.nih.gov/20590092 DMD4BFY DI DMD4BFY DMD4BFY DN Spermine DMD4BFY MI TT2LVK8 DMD4BFY MN Carbonic anhydrase IX (CA-IX) DMD4BFY MT DTT DMD4BFY MA Inhibitor DMD4BFY RN Polyamines inhibit carbonic anhydrases by anchoring to the zinc-coordinated water molecule. J Med Chem. 2010 Aug 12;53(15):5511-22. DMD4BFY RU https://pubmed.ncbi.nlm.nih.gov/20590092 DMD4BFY DI DMD4BFY DMD4BFY DN Spermine DMD4BFY MI TTCFSPE DMD4BFY MN Carbonic anhydrase VI (CA-VI) DMD4BFY MT DTT DMD4BFY MA Inhibitor DMD4BFY RN Polyamines inhibit carbonic anhydrases by anchoring to the zinc-coordinated water molecule. J Med Chem. 2010 Aug 12;53(15):5511-22. DMD4BFY RU https://pubmed.ncbi.nlm.nih.gov/20590092 DMD4BFY DI DMD4BFY DMD4BFY DN Spermine DMD4BFY MI TTEYTKG DMD4BFY MN Carbonic anhydrase XIV (CA-XIV) DMD4BFY MT DTT DMD4BFY MA Inhibitor DMD4BFY RN Polyamines inhibit carbonic anhydrases by anchoring to the zinc-coordinated water molecule. J Med Chem. 2010 Aug 12;53(15):5511-22. DMD4BFY RU https://pubmed.ncbi.nlm.nih.gov/20590092 DMD4BFY DI DMD4BFY DMD4BFY DN Spermine DMD4BFY MI TTLD29N DMD4BFY MN Glutamate receptor ionotropic NMDA 1 (NMDAR1) DMD4BFY MT DTT DMD4BFY MA Inhibitor DMD4BFY RN Bivalent beta-carbolines as potential multitarget anti-Alzheimer agents. J Med Chem. 2010 May 13;53(9):3611-7. DMD4BFY RU https://pubmed.ncbi.nlm.nih.gov/20361801 DMD4BFY DI DMD4BFY DMD4BFY DN Spermine DMD4BFY MI TTKJEMQ DMD4BFY MN Glutamate receptor ionotropic NMDA 2A (NMDAR2A) DMD4BFY MT DTT DMD4BFY MA Inhibitor DMD4BFY RN Bivalent beta-carbolines as potential multitarget anti-Alzheimer agents. J Med Chem. 2010 May 13;53(9):3611-7. DMD4BFY RU https://pubmed.ncbi.nlm.nih.gov/20361801 DMD4BFY DI DMD4BFY DMD4BFY DN Spermine DMD4BFY MI DTOFXP5 DMD4BFY MN MFS-type transporter SLC18B1 (SLC18B1) DMD4BFY MT DTP DMD4BFY MA Substrate DMD4BFY RN Identification of a mammalian vesicular polyamine transporter. Sci Rep. 2014 Oct 30;4:6836. DMD4BFY RU http://www.ncbi.nlm.nih.gov/pubmed/25355561 DMD4BFY DI DMD4BFY DMD4BFY DN Spermine DMD4BFY MI DEW7V0G DMD4BFY MN Polyamine oxidase (PAOX) DMD4BFY MT DME DMD4BFY MA Metabolism DMD4BFY RN Polyamine catabolism and disease. Biochem J. 2009 Jul 15;421(3):323-38. DMD4BFY RU https://www.ncbi.nlm.nih.gov/pubmed/?term=19589128 DMD4BFY DI DMD4BFY DMD4BFY DN Spermine DMD4BFY MI DEMWO83 DMD4BFY MN Putrescine acetyltransferase (SSAT1) DMD4BFY MT DME DMD4BFY MA Metabolism DMD4BFY RN Mechanistic and structural analysis of human spermidine/spermine N1-acetyltransferase. Biochemistry. 2007 Jun 19;46(24):7187-95. DMD4BFY RU https://www.ncbi.nlm.nih.gov/pubmed/?term=17516632 DMD4BFY DI DMD4BFY DMD4BFY DN Spermine DMD4BFY MI DEOH5V3 DMD4BFY MN Spermine oxidase (SMOX) DMD4BFY MT DME DMD4BFY MA Metabolism DMD4BFY RN Distinct immunomodulatory effects of spermine oxidase in colitis induced by epithelial injury or infection. Front Immunol. 2018 Jun 5;9:1242. DMD4BFY RU https://www.ncbi.nlm.nih.gov/pubmed/?term=29922289 DMTGIUV DI DMTGIUV DMTGIUV DN SPR-210 DMTGIUV MI TTFBNVI DMTGIUV MN Aldose reductase (AKR1B1) DMTGIUV MT DTT DMTGIUV MA Inhibitor DMTGIUV RN Pharmacological profiles of a novel aldose reductase inhibitor, SPR-210, and its effects on streptozotocin-induced diabetic rats. Jpn J Pharmacol. 1994 Feb;64(2):115-24. DMTGIUV RU https://pubmed.ncbi.nlm.nih.gov/8028228 DM6SW2R DI DM6SW2R DM6SW2R DN SQ-26332 DM6SW2R MI TTL69WB DM6SW2R MN Angiotensin-converting enzyme (ACE) DM6SW2R MT DTT DM6SW2R MA Inhibitor DM6SW2R RN Designed multiple ligands. An emerging drug discovery paradigm. J Med Chem. 2005 Oct 20;48(21):6523-43. DM6SW2R RU https://pubmed.ncbi.nlm.nih.gov/16220969 DM6SW2R DI DM6SW2R DM6SW2R DN SQ-26332 DM6SW2R MI TT5TKPM DM6SW2R MN Neutral endopeptidase (MME) DM6SW2R MT DTT DM6SW2R MA Inhibitor DM6SW2R RN Designed multiple ligands. An emerging drug discovery paradigm. J Med Chem. 2005 Oct 20;48(21):6523-43. DM6SW2R RU https://pubmed.ncbi.nlm.nih.gov/16220969 DM9DJFS DI DM9DJFS DM9DJFS DN SQ-28603 DM9DJFS MI TT5TKPM DM9DJFS MN Neutral endopeptidase (MME) DM9DJFS MT DTT DM9DJFS MA Modulator DM9DJFS RN Evaluation of SQ 28,603, an inhibitor of neutral endopeptidase, in conscious monkeys. Can J Physiol Pharmacol. 1991 Oct;69(10):1609-17. DM9DJFS RU https://pubmed.ncbi.nlm.nih.gov/1663819 DM083JB DI DM083JB DM083JB DN SQ-33351 DM083JB MI TT5HONZ DM083JB MN Calcium channel unspecific (CaC) DM083JB MT DTT DM083JB MA Modulator DM083JB RN Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800002577) DM083JB RU http://adisinsight.springer.com/drugs/800002577 DMT5LX0 DI DMT5LX0 DMT5LX0 DN SQ-33600 DMT5LX0 MI TTPADOQ DMT5LX0 MN HMG-CoA reductase (HMGCR) DMT5LX0 MT DTT DMT5LX0 MA Inhibitor DMT5LX0 RN Determination of SQ 33,600, a phosphinic acid containing HMG CoA reductase inhibitor, in human serum by high-performance liquid chromatography combined with ionspray mass spectrometry. Biol Mass Spectrom. 1992 Apr;21(4):189-94. DMT5LX0 RU https://pubmed.ncbi.nlm.nih.gov/1567915 DMMRWKP DI DMMRWKP DMMRWKP DN SQ-33800 DMMRWKP MI TTB2MXP DMMRWKP MN Angiotensinogenase renin (REN) DMMRWKP MT DTT DMMRWKP MA Inhibitor DMMRWKP RN Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800002406) DMMRWKP RU http://adisinsight.springer.com/drugs/800002406 DMZBQ4I DI DMZBQ4I DMZBQ4I DN SQ-33961 DMZBQ4I MI TT2O84V DMZBQ4I MN Thromboxane A2 receptor (TBXA2R) DMZBQ4I MT DTT DMZBQ4I MA Modulator DMZBQ4I RN Conformationally-restricted analogs of TXA2 antagonist SQ 33,961: Receptor binding conformation of the carboxyl sidechain. Bioorganic & Medicinal Chemistry Letters Volume 1, Issue 9, 1991, Pages 465-470. DMZBQ4I RU http://www.sciencedirect.com/science/article/pii/S0960894X01811070 DMT7O9V DI DMT7O9V DMT7O9V DN SQ-34919 DMT7O9V MI TTFQEO5 DMT7O9V MN Squalene synthetase (FDFT1) DMT7O9V MT DTT DMT7O9V MA Inhibitor DMT7O9V RN Inhibition of farnesyl protein transferase by new farnesyl phosphonate derivatives of phenylalanine, Bioorg. Med. Chem. Lett. 6(12):1291-1296 (1996). DMT7O9V RU http://www.sciencedirect.com/science/article/pii/0960894X96002387 DM4JZPT DI DM4JZPT DM4JZPT DN Squalestatin 1 DM4JZPT MI TTWTSCV DM4JZPT MN RAC-alpha serine/threonine-protein kinase (AKT1) DM4JZPT MT DTT DM4JZPT MA Inhibitor DM4JZPT RN Raft nanodomains contribute to Akt/PKB plasma membrane recruitment and activation. Nat Chem Biol. 2008 Sep;4(9):538-47. DM4JZPT RU https://pubmed.ncbi.nlm.nih.gov/18641634 DM4JZPT DI DM4JZPT DM4JZPT DN Squalestatin 1 DM4JZPT MI TTFQEO5 DM4JZPT MN Squalene synthetase (FDFT1) DM4JZPT MT DTT DM4JZPT MA Modulator DM4JZPT RN Squalestatin 1, a potent inhibitor of squalene synthase, which lowers serum cholesterol in vivo. J Biol Chem. 1992 Jun 15;267(17):11705-8. DM4JZPT RU https://pubmed.ncbi.nlm.nih.gov/1601846 DMETDFM DI DMETDFM DMETDFM DN SR 120819A DMETDFM MI TTRK9JT DMETDFM MN Neuropeptide Y receptor type 1 (NPY1R) DMETDFM MT DTT DMETDFM MA Antagonist DMETDFM RN SR 120819A, an orally-active and selective neuropeptide Y Y1 receptor antagonist. FEBS Lett. 1995 Apr 3;362(2):192-6. DMETDFM RU https://pubmed.ncbi.nlm.nih.gov/7720871 DMQG3CK DI DMQG3CK DMQG3CK DN SR-11237 DMQG3CK MI TTH029C DMQG3CK MN Retinoic acid receptor RXR-gamma (RXRG) DMQG3CK MT DTT DMQG3CK MA Modulator DMQG3CK RN Silicon analogues of the RXR-selective retinoid agonist SR11237 (BMS649): chemistry and biology. ChemMedChem. 2009 Jul;4(7):1143-52. DMQG3CK RU https://pubmed.ncbi.nlm.nih.gov/19496083 DMU2ZVY DI DMU2ZVY DMU2ZVY DN SR12813 DMU2ZVY MI TTPADOQ DMU2ZVY MN HMG-CoA reductase (HMGCR) DMU2ZVY MT DTT DMU2ZVY MA Modulator DMU2ZVY RN The novel cholesterol-lowering drug SR-12813 inhibits cholesterol synthesis via an increased degradation of 3-hydroxy-3-methylglutaryl-coenzyme A r... J Biol Chem. 1996 Jun 14;271(24):14376-82. DMU2ZVY RU https://www.ncbi.nlm.nih.gov/pubmed/8662919 DM1GKTS DI DM1GKTS DM1GKTS DN SR-26831 DM1GKTS MI TTPLTSQ DM1GKTS MN Neutrophil elastase (NE) DM1GKTS MT DTT DM1GKTS MA Modulator DM1GKTS RN Biochemical and pharmacological activities of SR 26831, a potent and selective elastase inhibitor. J Pharmacol Exp Ther. 1992 Feb;260(2):809-16. DM1GKTS RU https://pubmed.ncbi.nlm.nih.gov/1738126 DMZ8SXP DI DMZ8SXP DMZ8SXP DN SR-27950 DMZ8SXP MI TTCG0AL DMZ8SXP MN Cholecystokinin receptor type A (CCKAR) DMZ8SXP MT DTT DMZ8SXP MA Modulator DMZ8SXP RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 76). DMZ8SXP RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=76 DM7ZOLE DI DM7ZOLE DM7ZOLE DN SR-31742A DM7ZOLE MI TT5TPI6 DM7ZOLE MN Opioid receptor sigma 1 (OPRS1) DM7ZOLE MT DTT DM7ZOLE MA Binder DM7ZOLE RN The pipeline and future of drug development in schizophrenia. Mol Psychiatry. 2007 Oct;12(10):904-22. DM7ZOLE RU https://pubmed.ncbi.nlm.nih.gov/17667958 DMS9EJ5 DI DMS9EJ5 DMS9EJ5 DN SR-58878 DMS9EJ5 MI TTMXGCW DMS9EJ5 MN Adrenergic receptor beta-3 (ADRB3) DMS9EJ5 MT DTT DMS9EJ5 MA Modulator DMS9EJ5 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 30). DMS9EJ5 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=30 DMQUF9I DI DMQUF9I DMQUF9I DN SR-58894A DMQUF9I MI TTMXGCW DMQUF9I MN Adrenergic receptor beta-3 (ADRB3) DMQUF9I MT DTT DMQUF9I MA Modulator DMQUF9I RN Pharmacological characterization of beta-adrenoceptor subtypes mediating relaxation in porcine isolated ureteral smooth muscle. J Urol. 2004 Sep;172(3):1155-9. DMQUF9I RU https://pubmed.ncbi.nlm.nih.gov/15311061 DM6ASLF DI DM6ASLF DM6ASLF DN SR-80027A DM6ASLF MI TT6L509 DM6ASLF MN Coagulation factor IIa (F2) DM6ASLF MT DTT DM6ASLF MA Inhibitor DM6ASLF RN Pharmacokinetic and antithrombotic properties of two pentasaccharides with high affinity to antithrombin III in the rabbit: comparison with CY216. Blood. 1994 Oct 15;84(8):2571-7. DM6ASLF RU https://pubmed.ncbi.nlm.nih.gov/7919374 DMMPSY2 DI DMMPSY2 DMMPSY2 DN SRI 63-441 DMMPSY2 MI TT27K59 DMMPSY2 MN Platelet activating factor (PAF) DMMPSY2 MT DTT DMMPSY2 MA Inhibitor DMMPSY2 RN Pharmacologic modulation of experimental postischemic hepatic function. Ann Surg. 1989 Feb;209(2):200-10. DMMPSY2 RU https://pubmed.ncbi.nlm.nih.gov/2916864 DMBEUN6 DI DMBEUN6 DMBEUN6 DN SRI-3072 DMBEUN6 MI TT3C1VN DMBEUN6 MN Enzyme unspecific (Enz) DMBEUN6 MT DTT DMBEUN6 MA Inhibitor DMBEUN6 RN 2-Alkoxycarbonylaminopyridines: inhibitors of Mycobacterium tuberculosis FtsZ. J Antimicrob Chemother. 2002 Jul;50(1):111-4. DMBEUN6 RU https://pubmed.ncbi.nlm.nih.gov/12096015 DMFLPU5 DI DMFLPU5 DMFLPU5 DN SRSC-355 DMFLPU5 MI TTRK8B9 DMFLPU5 MN Sodium channel unspecific (NaC) DMFLPU5 MT DTT DMFLPU5 MA Modulator DMFLPU5 RN WO patent application no. 2013,0439,25, Sodium channel blockers reduce glucagon secretion. DMFLPU5 RU http://worldwide.espacenet.com/publicationDetails/biblio?DB=worldwide.espacenet.com&II=0&ND=3&adjacent=true&locale=en_EP&FT=D&date=20130328&CC=WO&NR=2013043925A1&KC=A1 DM8MZWR DI DM8MZWR DM8MZWR DN SRSS-021 DM8MZWR MI TTNXLKE DM8MZWR MN 5-HT 3 receptor (5HT3R) DM8MZWR MT DTT DM8MZWR MA Antagonist DM8MZWR RN Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800019090) DM8MZWR RU http://adisinsight.springer.com/drugs/800019090 DMUGPDB DI DMUGPDB DMUGPDB DN SRSS-023 DMUGPDB MI TTWT5K7 DMUGPDB MN 5-HT 1 receptor (5HT1R) DMUGPDB MT DTT DMUGPDB MA Agonist DMUGPDB RN Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800019089) DMUGPDB RU http://adisinsight.springer.com/drugs/800019089 DMWL4MI DI DMWL4MI DMWL4MI DN SSR-69071 DMWL4MI MI TT3NKIB DMWL4MI MN Pancreatic elastase 1 (CELA1) DMWL4MI MT DTT DMWL4MI MA Inhibitor DMWL4MI RN Pivotal role for alpha1-antichymotrypsin in skin repair. J Biol Chem. 2011 Aug 19;286(33):28889-901. DMWL4MI RU https://pubmed.ncbi.nlm.nih.gov/21693707 DMOJM08 DI DMOJM08 DMOJM08 DN Steroid hormone conjugates DMOJM08 MI TTPNQAC DMOJM08 MN Estrogen-related receptor-alpha (ESRRA) DMOJM08 MT DTT DMOJM08 MA Modulator DMOJM08 RN The effect of six months treatment with a 100 mg daily dose of dehydroepiandrosterone (DHEA) on circulating sex steroids, body composition and muscle strength in age-advanced men and women. Clin Endocrinol (Oxf). 1998 Oct;49(4):421-32. DMOJM08 RU https://pubmed.ncbi.nlm.nih.gov/9876338 DMO9UCK DI DMO9UCK DMO9UCK DN SU5614 DMO9UCK MI TTGJCWZ DMO9UCK MN Fms-like tyrosine kinase 3 (FLT-3) DMO9UCK MT DTT DMO9UCK MA Inhibitor DMO9UCK RN FMS-like tyrosine kinase 3-internal tandem duplication tyrosine kinase inhibitors display a nonoverlapping profile of resistance mutations in vitro. Cancer Res. 2009 Apr 1;69(7):3032-41. DMO9UCK RU https://pubmed.ncbi.nlm.nih.gov/19318574 DMWCR1Z DI DMWCR1Z DMWCR1Z DN SU-740 DMWCR1Z MI TTH18TF DMWCR1Z MN Muscarinic acetylcholine receptor M5 (CHRM5) DMWCR1Z MT DTT DMWCR1Z MA Modulator DMWCR1Z RN SU-840, a novel synthetic flavonoid derivative of sophoradin, with potent gastroprotective and ulcer healing activity. Journal of physiology and pharmacology. 49:1 1998 Mar pg 83-98 DMWCR1Z RU http://www.unboundmedicine.com/medline/citation/9594413/SU_840_a_novel_synthetic_flavonoid_derivative_of_sophoradin_with_potent_gastroprotective_and_ulcer_healing_activity_ DM4SVIR DI DM4SVIR DM4SVIR DN Sulotroban DM4SVIR MI TT2O84V DM4SVIR MN Thromboxane A2 receptor (TBXA2R) DM4SVIR MT DTT DM4SVIR MA Modulator DM4SVIR RN The PGI2-analogue iloprost and the TXA2-receptor antagonist sulotroban synergistically inhibit TXA2-dependent platelet activation. Prostaglandins. 1988 Dec;36(6):751-60. DM4SVIR RU https://pubmed.ncbi.nlm.nih.gov/2469101 DMC1A42 DI DMC1A42 DMC1A42 DN SUN-11031 DMC1A42 MI TTWDC17 DMC1A42 MN Growth hormone secretagogue receptor 1 (GHSR) DMC1A42 MT DTT DMC1A42 MA Agonist DMC1A42 RN Emerging drugs for eating disorder treatment. Expert Opin Emerg Drugs. 2006 May;11(2):315-36. DMC1A42 RU https://pubmed.ncbi.nlm.nih.gov/16634704 DMAM3OH DI DMAM3OH DMAM3OH DN SUN-E3001 DMAM3OH MI TT6F7GZ DMAM3OH MN Parathyroid hormone (PTH) DMAM3OH MT DTT DMAM3OH MA Modulator DMAM3OH RN Effects of teriparatide [recombinant human parathyroid hormone (1-34)] on cortical bone in postmenopausal women with osteoporosis. J Bone Miner Res. 2003 Mar;18(3):539-43. DMAM3OH RU https://www.ncbi.nlm.nih.gov/pubmed/12619939 DMG2SQM DI DMG2SQM DMG2SQM DN SYN-1134 DMG2SQM MI TT3NKIB DMG2SQM MN Pancreatic elastase 1 (CELA1) DMG2SQM MT DTT DMG2SQM MA Inhibitor DMG2SQM RN EP patent application no. 1292314, Method for treating respiratory disorders associated with pulmonary elastic fiber injury comprising the use of glycosaminoglycans. DMG2SQM RU http://www.google.com/patents/EP1292314A2?cl=en DMOGQ2L DI DMOGQ2L DMOGQ2L DN T-686 DMOGQ2L MI TT5QA2I DMOGQ2L MN Plasminogen activator inhibitor (PAI) DMOGQ2L MT DTT DMOGQ2L MA Inhibitor DMOGQ2L RN T-686, a novel inhibitor of plasminogen activator inhibitor-1, inhibits thrombosis without impairment of hemostasis in rats. Eur J Pharmacol. 1997 Jul 9;330(2-3):151-6. DMOGQ2L RU https://pubmed.ncbi.nlm.nih.gov/9253948 DM0TELR DI DM0TELR DM0TELR DN TAK-779 DM0TELR MI TT2CEJG DM0TELR MN C-C chemokine receptor type 5 (CCR5) DM0TELR MT DTT DM0TELR MA Antagonist DM0TELR RN Species selectivity of small-molecular antagonists for the CCR5 chemokine receptor. Int Immunopharmacol. 2007 Dec 5;7(12):1528-34. DM0TELR RU https://pubmed.ncbi.nlm.nih.gov/17920529 DM2OFBT DI DM2OFBT DM2OFBT DN Talisomycin DM2OFBT MI TTUTN1I DM2OFBT MN Human Deoxyribonucleic acid (hDNA) DM2OFBT MT DTT DM2OFBT MA Breaker DM2OFBT RN Bleomycin and talisomycin sequence-specific strand scission of DNA: a mechanism of double-strand cleavage. Cancer Res. 1982 Jul;42(7):2779-85. DM2OFBT RU https://pubmed.ncbi.nlm.nih.gov/6177398 DM54V0X DI DM54V0X DM54V0X DN Tamoxifen methyl iodide DM54V0X MI TTZAYWL DM54V0X MN Estrogen receptor (ESR) DM54V0X MT DTT DM54V0X MA Inhibitor DM54V0X RN Genomic action of permanently charged tamoxifen derivatives via estrogen receptor-alpha. Bioorg Med Chem. 2010 Aug 1;18(15):5593-601. DM54V0X RU https://pubmed.ncbi.nlm.nih.gov/20621492 DMU3BDY DI DMU3BDY DMU3BDY DN TAN-1496 DMU3BDY MI TTGTQHC DMU3BDY MN DNA topoisomerase I (TOP1) DMU3BDY MT DTT DMU3BDY MA Modulator DMU3BDY RN TAN-1496 A, C and E, diketopiperazine antibiotics with inhibitory activity against mammalian DNA topoisomerase I. J Antibiot (Tokyo). 1994 Nov;47(11):1202-18. DMU3BDY RU https://pubmed.ncbi.nlm.nih.gov/8002382 DM197D0 DI DM197D0 DM197D0 DN TAR-1 DM197D0 MI TT7SBF5 DM197D0 MN Cellular tumor antigen p53 (TP53) DM197D0 MT DTT DM197D0 RN Regulation of host gene expression by HIV-1 TAR microRNAs. Retrovirology. 2013; 10: 86. DM197D0 RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3751525/ DMCFGS6 DI DMCFGS6 DMCFGS6 DN TCV-295 DMCFGS6 MI TT1VOHK DMCFGS6 MN Potassium channel unspecific (KC) DMCFGS6 MT DTT DMCFGS6 MA Opener DMCFGS6 RN Antihypertensive and cardiovascular effects of a new potassium channel opener, TCV-295, in rats and dogs. J Cardiovasc Pharmacol. 1994 Dec;24(6):929-36. DMCFGS6 RU https://pubmed.ncbi.nlm.nih.gov/7898076 DMHS5DX DI DMHS5DX DMHS5DX DN TEI-6522 DMHS5DX MI TTMF541 DMHS5DX MN Liver carboxylesterase (CES1) DMHS5DX MT DTT DMHS5DX MA Modulator DMHS5DX RN Potent inhibitors of acyl-CoA:cholesterol acyltransferase. Structure-activity relationships of novel N-(4-oxochroman-8-yl)amides. J Med Chem. 1995 Aug 4;38(16):3174-86. DMHS5DX RU https://pubmed.ncbi.nlm.nih.gov/7636880 DMXM3B4 DI DMXM3B4 DMXM3B4 DN TEI-9874 DMXM3B4 MI TTYJQTF DMXM3B4 MN Immunoglobulin E (IgE) DMXM3B4 MT DTT DMXM3B4 MA Modulator DMXM3B4 RN Effect of TEI-9874, an inhibitor of immunoglobulin E production, on allergen-induced asthmatic model in rats. Eur J Pharmacol. 2000 Aug 25;402(3):287-95. DMXM3B4 RU https://pubmed.ncbi.nlm.nih.gov/10958896 DMQIYZR DI DMQIYZR DMQIYZR DN TER-16998 DMQIYZR MI TTCBFJO DMQIYZR MN Insulin receptor (INSR) DMQIYZR MT DTT DMQIYZR MA Activator DMQIYZR RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1800). DMQIYZR RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1800 DM2X5R6 DI DM2X5R6 DM2X5R6 DN TERIKALANT DM2X5R6 MI TT1VOHK DM2X5R6 MN Potassium channel unspecific (KC) DM2X5R6 MT DTT DM2X5R6 MA Modulator DM2X5R6 RN Terikalant, an inward-rectifier potassium channel blocker, does not abolish the cardioprotection induced by ischemic preconditioning in the rat. J Mol Cell Cardiol. 1998 Sep;30(9):1817-25. DM2X5R6 RU https://www.ncbi.nlm.nih.gov/pubmed/9769237 DMSRDGE DI DMSRDGE DMSRDGE DN TH-0318 DMSRDGE MI TTVIMDE DMSRDGE MN Glucagon-like peptide 1 receptor (GLP1R) DMSRDGE MT DTT DMSRDGE MA Modulator DMSRDGE RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 249). DMSRDGE RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=249 DMG1MPD DI DMG1MPD DMG1MPD DN TH-9229 DMG1MPD MI TTZIFHC DMG1MPD MN Voltage-gated calcium channel alpha Cav1.2 (CACNA1C) DMG1MPD MT DTT DMG1MPD MA Modulator DMG1MPD RN Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800008159) DMG1MPD RU http://adisinsight.springer.com/drugs/800008159 DMG1MPD DI DMG1MPD DMG1MPD DN TH-9229 DMG1MPD MI TT7RGTM DMG1MPD MN Voltage-gated calcium channel alpha Cav1.3 (CACNA1D) DMG1MPD MT DTT DMG1MPD MA Modulator DMG1MPD RN Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800008159) DMG1MPD RU http://adisinsight.springer.com/drugs/800008159 DMG1MPD DI DMG1MPD DMG1MPD DN TH-9229 DMG1MPD MI TTX4QDJ DMG1MPD MN Voltage-gated calcium channel alpha Cav2.1 (CACNA1A) DMG1MPD MT DTT DMG1MPD MA Modulator DMG1MPD RN Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800008159) DMG1MPD RU http://adisinsight.springer.com/drugs/800008159 DMG1MPD DI DMG1MPD DMG1MPD DN TH-9229 DMG1MPD MI TT4FDG6 DMG1MPD MN Voltage-gated calcium channel alpha Cav2.2 (CACNA1B) DMG1MPD MT DTT DMG1MPD MA Modulator DMG1MPD RN Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800008159) DMG1MPD RU http://adisinsight.springer.com/drugs/800008159 DMG1MPD DI DMG1MPD DMG1MPD DN TH-9229 DMG1MPD MI TTYRP0M DMG1MPD MN Voltage-gated calcium channel alpha Cav2.3 (CACNA1E) DMG1MPD MT DTT DMG1MPD MA Modulator DMG1MPD RN Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800008159) DMG1MPD RU http://adisinsight.springer.com/drugs/800008159 DM8S593 DI DM8S593 DM8S593 DN Thioperamide DM8S593 MI TT9JNIC DM8S593 MN Histamine H3 receptor (H3R) DM8S593 MT DTT DM8S593 MA Antagonist DM8S593 RN The histamine H3 receptor: from gene cloning to H3 receptor drugs. Nat Rev Drug Discov. 2005 Feb;4(2):107-20. DM8S593 RU https://pubmed.ncbi.nlm.nih.gov/15665857 DM8S593 DI DM8S593 DM8S593 DN Thioperamide DM8S593 MI TTXJ178 DM8S593 MN Histamine H4 receptor (H4R) DM8S593 MT DTT DM8S593 MA Antagonist DM8S593 RN Role of histamine in short- and long-term effects of methamphetamine on the developing mouse brain. J Neurochem. 2008 Nov;107(4):976-86. DM8S593 RU https://pubmed.ncbi.nlm.nih.gov/18786166 DM0SCDB DI DM0SCDB DM0SCDB DN TIAPAFANT DM0SCDB MI TTQL5VC DM0SCDB MN Platelet-activating factor receptor (PTAFR) DM0SCDB MT DTT DM0SCDB MA Antagonist DM0SCDB RN PCA-4248, a PAF receptor antagonist, inhibits PAF-induced phosphoinositide turnover. Eur J Pharmacol. 1995 Aug 15;290(3):183-8. DM0SCDB RU https://pubmed.ncbi.nlm.nih.gov/7589212 DMGCI6E DI DMGCI6E DMGCI6E DN Tipredane DMGCI6E MI TTTWGIX DMGCI6E MN Leukotriene receptor (LTR) DMGCI6E MT DTT DMGCI6E MA Modulator DMGCI6E RN New drugs for asthma. Nat Rev Drug Discov. 2004 Oct;3(10):831-44. DMGCI6E RU https://pubmed.ncbi.nlm.nih.gov/15459674 DM4YQDX DI DM4YQDX DM4YQDX DN TJN-220 DM4YQDX MI TTLWS2O DM4YQDX MN Calcitonin receptor (CALCR) DM4YQDX MT DTT DM4YQDX MA Modulator DM4YQDX RN Evaluation of the long-lasting antihypertensive action of 7-O-ethylfangchinoline. Jpn J Pharmacol. 1994 Sep;66(1):35-46. DM4YQDX RU https://pubmed.ncbi.nlm.nih.gov/7861666 DMKSPYI DI DMKSPYI DMKSPYI DN TJN-598 DMKSPYI MI TTZ97H5 DMKSPYI MN Phosphodiesterase 4A (PDE4A) DMKSPYI MT DTT DMKSPYI MA Inhibitor DMKSPYI RN Effects of TJN-598, a new selective phosphodiesterase type IV inhibitor on anti-Thy1 nephritis in rats. Clin Exp Nephrol. 2011 Feb;15(1):14-24. DMKSPYI RU https://pubmed.ncbi.nlm.nih.gov/20820840 DMKSPYI DI DMKSPYI DMKSPYI DN TJN-598 DMKSPYI MI TTVIAT9 DMKSPYI MN Phosphodiesterase 4B (PDE4B) DMKSPYI MT DTT DMKSPYI MA Inhibitor DMKSPYI RN Effects of TJN-598, a new selective phosphodiesterase type IV inhibitor on anti-Thy1 nephritis in rats. Clin Exp Nephrol. 2011 Feb;15(1):14-24. DMKSPYI RU https://pubmed.ncbi.nlm.nih.gov/20820840 DMKSPYI DI DMKSPYI DMKSPYI DN TJN-598 DMKSPYI MI TTSKMI8 DMKSPYI MN Phosphodiesterase 4D (PDE4D) DMKSPYI MT DTT DMKSPYI MA Inhibitor DMKSPYI RN Effects of TJN-598, a new selective phosphodiesterase type IV inhibitor on anti-Thy1 nephritis in rats. Clin Exp Nephrol. 2011 Feb;15(1):14-24. DMKSPYI RU https://pubmed.ncbi.nlm.nih.gov/20820840 DMTNB6G DI DMTNB6G DMTNB6G DN TNFQb therapeutic vaccines DMTNB6G MI TTF8CQI DMTNB6G MN Tumor necrosis factor (TNF) DMTNB6G MT DTT DMTNB6G RN Therapeutic Vaccination with TNF-Kinoid in TNF Antagonist-Resistant Rheumatoid Arthritis: A Phase II Randomized, Controlled Clinical Trial. PLoS One. 2014; 9(12): e113465. DMTNB6G RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4269456/ DMZKIE0 DI DMZKIE0 DMZKIE0 DN Tolerimab DMZKIE0 MI TTFZDNP DMZKIE0 MN Activation B7-1 antigen (CD80) DMZKIE0 MT DTT DMZKIE0 RN US patent application no. 2004,0171,123, Albumin fusion proteins. DMZKIE0 RU https://www.google.com/patents/US20040171123 DMZKIE0 DI DMZKIE0 DMZKIE0 DN Tolerimab DMZKIE0 MI TTHGXBU DMZKIE0 MN T-lymphocyte activation antigen CD86 (FUN1) DMZKIE0 MT DTT DMZKIE0 RN US patent application no. 2004,0171,123, Albumin fusion proteins. DMZKIE0 RU https://www.google.com/patents/US20040171123 DM385D9 DI DM385D9 DM385D9 DN Tomelukast DM385D9 MI TTGKOY9 DM385D9 MN Leukotriene CysLT1 receptor (CYSLTR1) DM385D9 MT DTT DM385D9 MA Modulator DM385D9 RN Effects of chronic treatment with the leukotriene D4 antagonist compound LY171883 on Fischer 344 rats and rhesus monkeys. Fundam Appl Toxicol. 1990 Jan;14(1):123-30. DM385D9 RU https://www.ncbi.nlm.nih.gov/pubmed/2307311 DMRBGI6 DI DMRBGI6 DMRBGI6 DN Torbafylline DMRBGI6 MI TTZ97H5 DMRBGI6 MN Phosphodiesterase 4A (PDE4A) DMRBGI6 MT DTT DMRBGI6 MA Inhibitor DMRBGI6 RN Phosphodiesterase (PDE) inhibitor torbafylline (HWA 448) attenuates burn-induced rat skeletal muscle proteolysis through the PDE4/cAMP/EPAC/PI3K/Akt pathway. Mol Cell Endocrinol. 2014 Aug 5;393(1-2):152-63. DMRBGI6 RU https://pubmed.ncbi.nlm.nih.gov/24973766 DMRBGI6 DI DMRBGI6 DMRBGI6 DN Torbafylline DMRBGI6 MI TTVIAT9 DMRBGI6 MN Phosphodiesterase 4B (PDE4B) DMRBGI6 MT DTT DMRBGI6 MA Modulator DMRBGI6 RN Phosphodiesterase (PDE) inhibitor torbafylline (HWA 448) attenuates burn-induced rat skeletal muscle proteolysis through the PDE4/cAMP/EPAC/PI3K/Akt pathway. Mol Cell Endocrinol. 2014 Aug 5;393(1-2):152-63. DMRBGI6 RU https://pubmed.ncbi.nlm.nih.gov/24973766 DMRBGI6 DI DMRBGI6 DMRBGI6 DN Torbafylline DMRBGI6 MI TTSKMI8 DMRBGI6 MN Phosphodiesterase 4D (PDE4D) DMRBGI6 MT DTT DMRBGI6 MA Modulator DMRBGI6 RN Phosphodiesterase (PDE) inhibitor torbafylline (HWA 448) attenuates burn-induced rat skeletal muscle proteolysis through the PDE4/cAMP/EPAC/PI3K/Akt pathway. Mol Cell Endocrinol. 2014 Aug 5;393(1-2):152-63. DMRBGI6 RU https://pubmed.ncbi.nlm.nih.gov/24973766 DM5ZNSQ DI DM5ZNSQ DM5ZNSQ DN TP-20 DM5ZNSQ MI TT6ATLX DM5ZNSQ MN Complement factor I (CFI) DM5ZNSQ MT DTT DM5ZNSQ MA Inhibitor DM5ZNSQ RN Endothelial targeting and enhanced antiinflammatory effects of complement inhibitors possessing sialyl Lewisx moieties. J Immunol. 1999 Apr 15;162(8):4952-9. DM5ZNSQ RU https://pubmed.ncbi.nlm.nih.gov/10202042 DMQRSMD DI DMQRSMD DMQRSMD DN Trequinsin DMQRSMD MI TTJ0IQB DMQRSMD MN Phosphodiesterase 5A (PDE5A) DMQRSMD MT DTT DMQRSMD MA Inhibitor DMQRSMD RN Inhibition of cyclic adenosine-3',5'-monophosphate phosphodiesterase from vascular smooth muscle by rolipram analogues. J Med Chem. 1989 Jul;32(7):1450-7. DMQRSMD RU https://pubmed.ncbi.nlm.nih.gov/2544722 DMUHBSI DI DMUHBSI DMUHBSI DN Tridegin DMUHBSI MI TTAXGIP DMUHBSI MN Coagulation factor XIII (F13B) DMUHBSI MT DTT DMUHBSI MA Modulator DMUHBSI RN Tridegin, a new peptidic inhibitor of factor XIIIa, from the blood-sucking leech Haementeria ghilianii. Biochem J. 1997 Jun 15;324 ( Pt 3):797-805. DMUHBSI RU https://www.ncbi.nlm.nih.gov/pubmed/9210403 DMASENP DI DMASENP DMASENP DN TULOPAFANT DMASENP MI TTQL5VC DMASENP MN Platelet-activating factor receptor (PTAFR) DMASENP MT DTT DMASENP MA Antagonist DMASENP RN Tulopafant, a PAF receptor antagonist, increases capillary patency and prolongs survival in discordant cardiac xenotransplants. J Lipid Mediat. 1993 May;7(1):79-84. DMASENP RU https://pubmed.ncbi.nlm.nih.gov/8395256 DMR3S9B DI DMR3S9B DMR3S9B DN Tyloxapol DMR3S9B MI TTSXVID DMR3S9B MN Nuclear factor NF-kappa-B (NFKB) DMR3S9B MT DTT DMR3S9B MA Inhibitor DMR3S9B RN Study of influence of additives of tyloxapol on the chromatographic characteristics of the model compounds: the comparative characterization of micellar mobile phases of tyloxapol and Triton X-100. Biomed Chromatogr. 2009 Jul;23(7):700-6. DMR3S9B RU https://pubmed.ncbi.nlm.nih.gov/19309752 DM4WUEP DI DM4WUEP DM4WUEP DN U-54494A DM4WUEP MI TTRK8B9 DM4WUEP MN Sodium channel unspecific (NaC) DM4WUEP MT DTT DM4WUEP MA Modulator DM4WUEP RN U-54494A: a unique anticonvulsant related to kappa opioid agonists. J Pharmacol Exp Ther. 1987 Nov;243(2):542-7. DM4WUEP RU https://pubmed.ncbi.nlm.nih.gov/2824750 DMRBXEA DI DMRBXEA DMRBXEA DN U-75875 DMRBXEA MI TT5FNQT DMRBXEA MN Human immunodeficiency virus Protease (HIV PR) DMRBXEA MT DTT DMRBXEA MA Modulator DMRBXEA RN Effects of U-75875, a peptidomimetic inhibitor of retroviral proteases, on simian immunodeficiency virus infection in rhesus monkeys. Antimicrob Agents Chemother. 1994 Jun;38(6):1277-83. DMRBXEA RU https://pubmed.ncbi.nlm.nih.gov/7522427 DMGUMWP DI DMGUMWP DMGUMWP DN U-80816 DMGUMWP MI TTOXS3C DMGUMWP MN Muscarinic acetylcholine receptor (CHRM) DMGUMWP MT DTT DMGUMWP MA Modulator DMGUMWP RN U-80816: A novel partial muscarinic agonist. Drug Development Research Volume 24, Issue 1, pages 53-66, 1991. DMGUMWP RU http://onlinelibrary.wiley.com/doi/10.1002/ddr.430240105/abstract DMTMZJ4 DI DMTMZJ4 DMTMZJ4 DN U-90042 DMTMZJ4 MI TTNJYV2 DMTMZJ4 MN Gamma-aminobutyric acid receptor (GAR) DMTMZJ4 MT DTT DMTMZJ4 MA Modulator DMTMZJ4 RN U-90042, a sedative/hypnotic compound that interacts differentially with the GABAA receptor subtypes. J Pharmacol Exp Ther. 1995 Nov;275(2):761-7. DMTMZJ4 RU https://pubmed.ncbi.nlm.nih.gov/7473164 DMTYO3P DI DMTYO3P DMTYO3P DN U-92032 DMTYO3P MI TTRK8B9 DMTYO3P MN Sodium channel unspecific (NaC) DMTYO3P MT DTT DMTYO3P MA Inhibitor DMTYO3P RN Discovery of (2S)-1-(4-amino-2,3,5- trimethylphenoxy)-3-[4-[4-(4- fluorobenzyl)phenyl]-1-piperazinyl]-2-propanol dimethanesulfonate (SUN N8075): a ... J Med Chem. 2000 Sep 7;43(18):3372-6. DMTYO3P RU https://pubmed.ncbi.nlm.nih.gov/10978184 DMTYO3P DI DMTYO3P DMTYO3P DN U-92032 DMTYO3P MI TTZPWGN DMTYO3P MN Voltage-gated calcium channel alpha Cav3.2 (CACNA1H) DMTYO3P MT DTT DMTYO3P MA Inhibitor DMTYO3P RN Discovery of (2S)-1-(4-amino-2,3,5- trimethylphenoxy)-3-[4-[4-(4- fluorobenzyl)phenyl]-1-piperazinyl]-2-propanol dimethanesulfonate (SUN N8075): a ... J Med Chem. 2000 Sep 7;43(18):3372-6. DMTYO3P RU https://pubmed.ncbi.nlm.nih.gov/10978184 DMTYO3P DI DMTYO3P DMTYO3P DN U-92032 DMTYO3P MI TTQZFTH DMTYO3P MN Voltage-gated calcium channel alpha Cav3.3 (CACNA1I) DMTYO3P MT DTT DMTYO3P MA Inhibitor DMTYO3P RN Discovery of (2S)-1-(4-amino-2,3,5- trimethylphenoxy)-3-[4-[4-(4- fluorobenzyl)phenyl]-1-piperazinyl]-2-propanol dimethanesulfonate (SUN N8075): a ... J Med Chem. 2000 Sep 7;43(18):3372-6. DMTYO3P RU https://pubmed.ncbi.nlm.nih.gov/10978184 DMTYO3P DI DMTYO3P DMTYO3P DN U-92032 DMTYO3P MI TTAXZ0K DMTYO3P MN Voltage-gated sodium channel alpha Nav1.3 (SCN3A) DMTYO3P MT DTT DMTYO3P MA Inhibitor DMTYO3P RN Discovery of (2S)-1-(4-amino-2,3,5- trimethylphenoxy)-3-[4-[4-(4- fluorobenzyl)phenyl]-1-piperazinyl]-2-propanol dimethanesulfonate (SUN N8075): a ... J Med Chem. 2000 Sep 7;43(18):3372-6. DMTYO3P RU https://pubmed.ncbi.nlm.nih.gov/10978184 DM0Z7PK DI DM0Z7PK DM0Z7PK DN UC-38 DM0Z7PK MI TT84ETX DM0Z7PK MN Human immunodeficiency virus Reverse transcriptase (HIV RT) DM0Z7PK MT DTT DM0Z7PK MA Modulator DM0Z7PK RN Biological and biochemical anti-human immunodeficiency virus activity of UC 38, a new non-nucleoside reverse transcriptase inhibitor. J Pharmacol Exp Ther. 1996 Jan;276(1):298-305. DM0Z7PK RU https://pubmed.ncbi.nlm.nih.gov/8558446 DMY9UEZ DI DMY9UEZ DMY9UEZ DN UC-84 DMY9UEZ MI TT84ETX DMY9UEZ MN Human immunodeficiency virus Reverse transcriptase (HIV RT) DMY9UEZ MT DTT DMY9UEZ MA Modulator DMY9UEZ RN Crystal structures of HIV-1 reverse transcriptase in complex with carboxanilide derivatives. Biochemistry. 1998 Oct 13;37(41):14394-403. DMY9UEZ RU https://pubmed.ncbi.nlm.nih.gov/9772165 DMD3CA5 DI DMD3CA5 DMD3CA5 DN UCL-1390 DMD3CA5 MI TT9JNIC DMD3CA5 MN Histamine H3 receptor (H3R) DMD3CA5 MT DTT DMD3CA5 MA Antagonist DMD3CA5 RN Emerging drugs for eating disorder treatment. Expert Opin Emerg Drugs. 2006 May;11(2):315-36. DMD3CA5 RU https://pubmed.ncbi.nlm.nih.gov/16634704 DM9FT5E DI DM9FT5E DM9FT5E DN UD-CG-212 DM9FT5E MI TTZCG4L DM9FT5E MN Phosphodiesterase 3 (PDE3) DM9FT5E MT DTT DM9FT5E MA Modulator DM9FT5E RN Phosphodiesterase inhibition in ventricular cardiomyocytes from guinea-pig hearts. Br J Pharmacol. 1992 Sep;107(1):127-33. DM9FT5E RU https://www.ncbi.nlm.nih.gov/pubmed/1384905 DMQFSAB DI DMQFSAB DMQFSAB DN UK-290795 DMQFSAB MI TTYO0A3 DMQFSAB MN Substance-K receptor (TACR2) DMQFSAB MT DTT DMQFSAB MA Antagonist DMQFSAB RN Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800017162) DMQFSAB RU http://adisinsight.springer.com/drugs/800017162 DM23YPS DI DM23YPS DM23YPS DN UK-51656 DM23YPS MI TT5HONZ DM23YPS MN Calcium channel unspecific (CaC) DM23YPS MT DTT DM23YPS MA Modulator DM23YPS RN Long-acting dihydropyridine calcium antagonists. 4. Synthesis and structure-activity relationships for a series of basic and nonbasic derivatives of 2-[(2-aminoethoxy)methyl]-1,4-dihydropyridine calcium antagonists. J Med Chem. 1990 Feb;33(2):585-91. DM23YPS RU https://pubmed.ncbi.nlm.nih.gov/2153819 DMKBILF DI DMKBILF DMKBILF DN UK-78282 DMKBILF MI TTY3UE6 DMKBILF MN Voltage-gated potassium channel Kv1.3 (KCNA3) DMKBILF MT DTT DMKBILF MA Inhibitor DMKBILF RN Angular methoxy-substituted furo- and pyranoquinolinones as blockers of the voltage-gated potassium channel Kv1.3. J Med Chem. 2001 Apr 12;44(8):1249-56. DMKBILF RU https://pubmed.ncbi.nlm.nih.gov/11312924 DMEIR7F DI DMEIR7F DMEIR7F DN UP-116-77 DMEIR7F MI TT2O84V DMEIR7F MN Thromboxane A2 receptor (TBXA2R) DMEIR7F MT DTT DMEIR7F MA Modulator DMEIR7F RN Synthesis and structure-activity relationships of novel benzimidazole and imidazo[4,5-b]pyridine acid derivatives as thromboxane A2 receptor antagonists. J Med Chem. 1993 Apr 30;36(9):1175-87. DMEIR7F RU https://pubmed.ncbi.nlm.nih.gov/8487256 DM37DOC DI DM37DOC DM37DOC DN UP-275-22 DM37DOC MI TT8DBY3 DM37DOC MN Angiotensin II receptor type-1 (AGTR1) DM37DOC MT DTT DM37DOC MA Modulator DM37DOC RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 34). DM37DOC RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=34 DMV8GUE DI DMV8GUE DMV8GUE DN UR-12460 DMV8GUE MI TTQL5VC DMV8GUE MN Platelet-activating factor receptor (PTAFR) DMV8GUE MT DTT DMV8GUE MA Modulator DMV8GUE RN Platelet-activating factor: the effector of protein-rich plasma extravasation and nitric oxide synthase induction in rat immune complex peritonitis. Br J Pharmacol. 1995 Feb;114(4):895-901. DMV8GUE RU https://pubmed.ncbi.nlm.nih.gov/7539698 DM7F94W DI DM7F94W DM7F94W DN UR-12670 DM7F94W MI TT27K59 DM7F94W MN Platelet activating factor (PAF) DM7F94W MT DTT DM7F94W MA Inhibitor DM7F94W RN Long-term protective effect of UR-12670 after warm renal ischemia in uninephrectomized rats. Kidney Int. 1999 Nov;56(5):1798-808. DM7F94W RU https://pubmed.ncbi.nlm.nih.gov/10571788 DMJC82N DI DMJC82N DMJC82N DN UR-8225 DMJC82N MI TT1VOHK DMJC82N MN Potassium channel unspecific (KC) DMJC82N MT DTT DMJC82N MA Opener DMJC82N RN Effects of the novel potassium channel opener, UR-8225, on contractile responses in rat isolated smooth muscle. Br J Pharmacol. 1993 Nov;110(3):1165-71. DMJC82N RU https://pubmed.ncbi.nlm.nih.gov/8298804 DM6C7WJ DI DM6C7WJ DM6C7WJ DN UR-8308 DM6C7WJ MI TT1VOHK DM6C7WJ MN Potassium channel unspecific (KC) DM6C7WJ MT DTT DM6C7WJ MA Opener DM6C7WJ RN Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800005294) DM6C7WJ RU http://adisinsight.springer.com/drugs/800005294 DM4KOTA DI DM4KOTA DM4KOTA DN UR-8328 DM4KOTA MI TT1VOHK DM4KOTA MN Potassium channel unspecific (KC) DM4KOTA MT DTT DM4KOTA MA Opener DM4KOTA RN Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800005293) DM4KOTA RU http://adisinsight.springer.com/drugs/800005293 DM73EPK DI DM73EPK DM73EPK DN Vapaliximab DM73EPK MI TT7HC21 DM73EPK MN Membrane copper amine oxidase (AOC3) DM73EPK MT DTT DM73EPK RN Clinical pipeline report, company report or official report of Huginonline. DM73EPK RU http://reports.huginonline.com/845929/98523.pdf DMJLV03 DI DMJLV03 DMJLV03 DN Vapiprost DMJLV03 MI TT2O84V DMJLV03 MN Thromboxane A2 receptor (TBXA2R) DMJLV03 MT DTT DMJLV03 MA Modulator DMJLV03 RN Effects of vapiprost, a novel thromboxane receptor antagonist, on thrombus formation and vascular patency after thrombolysis by tissue-type plasminogen activator.. Br J Pharmacol. 1992 July; 106(3): 533-538. DMJLV03 RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1907568/ DMHG70W DI DMHG70W DMHG70W DN VE-16084 DMHG70W MI TTCQIBE DMHG70W MN Caspase-1 (CASP1) DMHG70W MT DTT DMHG70W MA Inhibitor DMHG70W RN Interleukin-1 beta converting enzyme inhibition blocks progression of type II collagen-induced arthritis in mice. Cytokine. 1996 May;8(5):377-86. DMHG70W RU https://pubmed.ncbi.nlm.nih.gov/8726666 DMY0V6J DI DMY0V6J DMY0V6J DN VG-106 DMY0V6J MI TTXM6JN DMY0V6J MN Cytokine receptor unspecific (CRF) DMY0V6J MT DTT DMY0V6J MA Modulator DMY0V6J RN WO patent application no. 2011,0955,45, Peptides capable of binding to serum albumin and compounds, constructs and polypeptides comprising the same. DMY0V6J RU http://worldwide.espacenet.com/publicationDetails/biblio?DB=worldwide.espacenet.com&II=0&ND=3&adjacent=true&locale=en_EP&FT=D&date=20110811&CC=WO&NR=2011095545A1&KC=A1 DMLWQOP DI DMLWQOP DMLWQOP DN VR-147 DMLWQOP MI TTK8CXU DMLWQOP MN 5-HT 1B receptor (HTR1B) DMLWQOP MT DTT DMLWQOP MA Modulator DMLWQOP RN US patent application no. 2010,0112,050, Dosage form for insertion into the mouth. DMLWQOP RU http://www.google.com/patents/US20100112050 DMLWQOP DI DMLWQOP DMLWQOP DN VR-147 DMLWQOP MI TT6MSOK DMLWQOP MN 5-HT 1D receptor (HTR1D) DMLWQOP MT DTT DMLWQOP MA Modulator DMLWQOP RN US patent application no. 2010,0112,050, Dosage form for insertion into the mouth. DMLWQOP RU http://www.google.com/patents/US20100112050 DM0CWJZ DI DM0CWJZ DM0CWJZ DN VUF-8929 DM0CWJZ MI TT5HONZ DM0CWJZ MN Calcium channel unspecific (CaC) DM0CWJZ MT DTT DM0CWJZ MA Modulator DM0CWJZ RN In vitro and in vivo characterization of a calcium modulator of the diphenylalkylamine type with selective coronary dilatory properties. Arzneimittelforschung. 1997 Nov;47(11):1211-8. DM0CWJZ RU https://pubmed.ncbi.nlm.nih.gov/9428976 DMG58FX DI DMG58FX DMG58FX DN WAY-100635 DMG58FX MI TTSQIFT DMG58FX MN 5-HT 1A receptor (HTR1A) DMG58FX MT DTT DMG58FX MA Antagonist DMG58FX RN Pharmacological characterization of recombinant human 5-hydroxytryptamine1A receptors using a novel antagonist radioligand, [3H]WAY-100635. Life Sci. 1997;60(9):653-65. DMG58FX RU https://pubmed.ncbi.nlm.nih.gov/9048968 DMMOS8G DI DMMOS8G DMMOS8G DN WAY-123223 DMMOS8G MI TT1VOHK DMMOS8G MN Potassium channel unspecific (KC) DMMOS8G MT DTT DMMOS8G MA Opener DMMOS8G RN Synthesis and selective class III antiarrhythmic activity of novel N-heteroaralkyl-substituted 1-(aryloxy)-2-propanolamine and related propylamine derivatives. J Med Chem. 1991 Nov;34(11):3212-28. DMMOS8G RU https://pubmed.ncbi.nlm.nih.gov/1956040 DMTY7PE DI DMTY7PE DMTY7PE DN WAY-126227 DMTY7PE MI TTGN1ZA DMTY7PE MN Angiotensin II receptor (AGTR) DMTY7PE MT DTT DMTY7PE MA Modulator DMTY7PE RN WO patent application no. 1996,0402,58, Spironolactone and angiotensin ii antagonist combination therapy for treatment of congestive heart failure. DMTY7PE RU http://www.google.com/patents/WO1996040258A2?cl=en DM2XTB9 DI DM2XTB9 DM2XTB9 DN WAY-132983 DM2XTB9 MI TTZ9SOR DM2XTB9 MN Muscarinic acetylcholine receptor M1 (CHRM1) DM2XTB9 MT DTT DM2XTB9 MA Agonist DM2XTB9 RN Pharmacological comparison of muscarinic ligands: historical versus more recent muscarinic M1-preferring receptor agonists. Eur J Pharmacol. 2009 Mar 1;605(1-3):53-6. DM2XTB9 RU https://pubmed.ncbi.nlm.nih.gov/19168056 DMQU8B1 DI DMQU8B1 DMQU8B1 DN WB-4101 DMQU8B1 MI TTSQIFT DMQU8B1 MN 5-HT 1A receptor (HTR1A) DMQU8B1 MT DTT DMQU8B1 MA Inhibitor DMQU8B1 RN Synthesis of (R,S)-trans-8-hydroxy-2-[N-n-propyl-N-(3'-iodo-2'-propenyl)amino]tetral in (trans-8-OH-PIPAT): a new 5-HT1A receptor ligand. J Med Chem. 1993 Oct 15;36(21):3161-5. DMQU8B1 RU https://pubmed.ncbi.nlm.nih.gov/8230102 DMQU8B1 DI DMQU8B1 DMQU8B1 DN WB-4101 DMQU8B1 MI TTNGILX DMQU8B1 MN Adrenergic receptor alpha-1A (ADRA1A) DMQU8B1 MT DTT DMQU8B1 MA Inhibitor DMQU8B1 RN Alpha- and beta-adrenoceptors: from the gene to the clinic. 1. Molecular biology and adrenoceptor subclassification. J Med Chem. 1995 Sep 1;38(18):3415-44. DMQU8B1 RU https://pubmed.ncbi.nlm.nih.gov/7658428 DMQU8B1 DI DMQU8B1 DMQU8B1 DN WB-4101 DMQU8B1 MI TTBRKXS DMQU8B1 MN Adrenergic receptor alpha-1B (ADRA1B) DMQU8B1 MT DTT DMQU8B1 MA Inhibitor DMQU8B1 RN Alpha- and beta-adrenoceptors: from the gene to the clinic. 1. Molecular biology and adrenoceptor subclassification. J Med Chem. 1995 Sep 1;38(18):3415-44. DMQU8B1 RU https://pubmed.ncbi.nlm.nih.gov/7658428 DMQU8B1 DI DMQU8B1 DMQU8B1 DN WB-4101 DMQU8B1 MI TT34BHT DMQU8B1 MN Adrenergic receptor alpha-1D (ADRA1D) DMQU8B1 MT DTT DMQU8B1 MA Inhibitor DMQU8B1 RN Alpha- and beta-adrenoceptors: from the gene to the clinic. 1. Molecular biology and adrenoceptor subclassification. J Med Chem. 1995 Sep 1;38(18):3415-44. DMQU8B1 RU https://pubmed.ncbi.nlm.nih.gov/7658428 DMQU8B1 DI DMQU8B1 DMQU8B1 DN WB-4101 DMQU8B1 MI TTWG9A4 DMQU8B1 MN Adrenergic receptor alpha-2A (ADRA2A) DMQU8B1 MT DTT DMQU8B1 MA Inhibitor DMQU8B1 RN alpha 2 adrenoceptors: classification, localization, mechanisms, and targets for drugs. J Med Chem. 1982 Dec;25(12):1389-401. DMQU8B1 RU https://pubmed.ncbi.nlm.nih.gov/6296387 DMQU8B1 DI DMQU8B1 DMQU8B1 DN WB-4101 DMQU8B1 MI TTWM4TY DMQU8B1 MN Adrenergic receptor alpha-2B (ADRA2B) DMQU8B1 MT DTT DMQU8B1 MA Inhibitor DMQU8B1 RN alpha 2 adrenoceptors: classification, localization, mechanisms, and targets for drugs. J Med Chem. 1982 Dec;25(12):1389-401. DMQU8B1 RU https://pubmed.ncbi.nlm.nih.gov/6296387 DMQU8B1 DI DMQU8B1 DMQU8B1 DN WB-4101 DMQU8B1 MI TT2NUT5 DMQU8B1 MN Adrenergic receptor alpha-2C (ADRA2C) DMQU8B1 MT DTT DMQU8B1 MA Inhibitor DMQU8B1 RN alpha 2 adrenoceptors: classification, localization, mechanisms, and targets for drugs. J Med Chem. 1982 Dec;25(12):1389-401. DMQU8B1 RU https://pubmed.ncbi.nlm.nih.gov/6296387 DMY9NG1 DI DMY9NG1 DMY9NG1 DN WEB-2347 DMY9NG1 MI TTQL5VC DMY9NG1 MN Platelet-activating factor receptor (PTAFR) DMY9NG1 MT DTT DMY9NG1 MA Modulator DMY9NG1 RN WEB 2347: pharmacology of a new very potent and long acting hetrazepinoic PAF-antagonist and its action in repeatedly sensitized guinea-pigs. J Lipid Mediat. 1991 Jul-Aug;4(1):39-44. DMY9NG1 RU https://pubmed.ncbi.nlm.nih.gov/1893086 DMBMOI6 DI DMBMOI6 DMBMOI6 DN WF-2421 DMBMOI6 MI TTFBNVI DMBMOI6 MN Aldose reductase (AKR1B1) DMBMOI6 MT DTT DMBMOI6 MA Modulator DMBMOI6 RN WF-2421, a new aldose reductase inhibitor produced from a fungus, Humicola grisea. J Antibiot (Tokyo). 1991 Feb;44(2):130-5. DMBMOI6 RU https://pubmed.ncbi.nlm.nih.gov/1901310 DMACBIW DI DMACBIW DMACBIW DN WIN-55212-2 DMACBIW MI TT6OEDT DMACBIW MN Cannabinoid receptor 1 (CB1) DMACBIW MT DTT DMACBIW MA Inhibitor DMACBIW RN Synthesis and pharmacological evaluation of coumarin derivatives as cannabinoid receptor antagonists and inverse agonists. Bioorg Med Chem. 2009 Apr 1;17(7):2842-51. DMACBIW RU https://pubmed.ncbi.nlm.nih.gov/19278853 DMACBIW DI DMACBIW DMACBIW DN WIN-55212-2 DMACBIW MI TTMSFAW DMACBIW MN Cannabinoid receptor 2 (CB2) DMACBIW MT DTT DMACBIW MA Inhibitor DMACBIW RN Synthesis and cannabinoid activity of 1-substituted-indole-3-oxadiazole derivatives: novel agonists for the CB1 receptor. Eur J Med Chem. 2008 Mar;43(3):513-39. DMACBIW RU https://pubmed.ncbi.nlm.nih.gov/17582659 DMACBIW DI DMACBIW DMACBIW DN WIN-55212-2 DMACBIW MI DE4LYSA DMACBIW MN Cytochrome P450 3A4 (CYP3A4) DMACBIW MT DME DMACBIW MA Metabolism DMACBIW RN Integrated analysis on the physicochemical properties of dihydropyridine calcium channel blockers in grapefruit juice interactions. Curr Pharm Biotechnol. 2012 Jul;13(9):1705-17. DMACBIW RU https://www.ncbi.nlm.nih.gov/pubmed/?term=22039822 DMRV48P DI DMRV48P DMRV48P DN WIN-63759 DMRV48P MI TT3NKIB DMRV48P MN Pancreatic elastase 1 (CELA1) DMRV48P MT DTT DMRV48P MA Modulator DMRV48P RN Biological activity of WIN 63759, an orally bioavailable inhibitor of human neutrophil elastase. Drug Development Research Volume 34, Issue 3, pages 306-316, March 1995. DMRV48P RU http://onlinelibrary.wiley.com/doi/10.1002/ddr.430340308/abstract DM960I8 DI DM960I8 DM960I8 DN WIN-64821 DM960I8 MI TTZPO1L DM960I8 MN Substance-P receptor (TACR1) DM960I8 MT DTT DM960I8 MA Antagonist DM960I8 RN WIN 64821, a novel neurokinin antagonist produced by an Aspergillus sp. II. Biological activity. J Antibiot (Tokyo). 1994 Apr;47(4):399-410. DM960I8 RU https://pubmed.ncbi.nlm.nih.gov/7515038 DM8EVK5 DI DM8EVK5 DM8EVK5 DN Wortmannin DM8EVK5 MI TTGBPJE DM8EVK5 MN PI3-kinase delta (PIK3CD) DM8EVK5 MT DTT DM8EVK5 MA Inhibitor DM8EVK5 RN Selective role of PI3K delta in neutrophil inflammatory responses. Biochem Biophys Res Commun. 2003 Sep 5;308(4):764-9. DM8EVK5 RU https://pubmed.ncbi.nlm.nih.gov/12927784 DM8EVK5 DI DM8EVK5 DM8EVK5 DN Wortmannin DM8EVK5 MI TTHBTOP DM8EVK5 MN PI3-kinase gamma (PIK3CG) DM8EVK5 MT DTT DM8EVK5 MA Inhibitor DM8EVK5 RN Phosphatidylinositol 3-kinase/Akt signaling in the response of vascular endothelium to ionizing radiation. Cancer Res. 2002 Aug 15;62(16):4671-7. DM8EVK5 RU https://pubmed.ncbi.nlm.nih.gov/12183424 DM89BA1 DI DM89BA1 DM89BA1 DN WS-75624B DM89BA1 MI TT1BGDH DM89BA1 MN Endothelin-converting enzyme (ECE) DM89BA1 MT DTT DM89BA1 MA Modulator DM89BA1 RN WS75624 A and B, new endothelin converting enzyme inhibitors isolated from Saccharothrix sp. No. 75624. II. Structure elucidation of WS75624 A and B. J Antibiot (Tokyo). 1995 Oct;48(10):1073-5. DM89BA1 RU https://pubmed.ncbi.nlm.nih.gov/7490209 DMAG86C DI DMAG86C DMAG86C DN WY-28342 DMAG86C MI TT2J34L DMAG86C MN Arachidonate 5-lipoxygenase (5-LOX) DMAG86C MT DTT DMAG86C MA Modulator DMAG86C RN Synthesis and antiinflammatory activity of certain 5,6,7,8-tetrahydroquinolines and related compounds. J Med Chem. 1995 Apr 28;38(9):1473-81. DMAG86C RU https://pubmed.ncbi.nlm.nih.gov/7739006 DMAG86C DI DMAG86C DMAG86C DN WY-28342 DMAG86C MI TTK0943 DMAG86C MN Prostaglandin G/H synthase (COX) DMAG86C MT DTT DMAG86C MA Modulator DMAG86C RN Synthesis and antiinflammatory activity of certain 5,6,7,8-tetrahydroquinolines and related compounds. J Med Chem. 1995 Apr 28;38(9):1473-81. DMAG86C RU https://pubmed.ncbi.nlm.nih.gov/7739006 DMGJNQW DI DMGJNQW DMGJNQW DN WY-48989 DMGJNQW MI TTZBFA0 DMGJNQW MN Protease unspecific (PRO) DMGJNQW MT DTT DMGJNQW MA Modulator DMGJNQW RN Inhibition of interleukin-1 (IL-1) induced neutral proteases from rabbit articular chondrocytes by WY-46,135 and WY-48,989. Agents Actions. 1991 Sep;34(1-2):223-5. DMGJNQW RU https://pubmed.ncbi.nlm.nih.gov/1665295 DM965P4 DI DM965P4 DM965P4 DN XL-541 DM965P4 MI TT9JZCK DM965P4 MN Sphingosine-1-phosphate receptor 1 (S1PR1) DM965P4 MT DTT DM965P4 MA Antagonist DM965P4 RN Discovery of a novel class of potent and orally bioavailable sphingosine 1-phosphate receptor 1 antagonists. J Med Chem. 2012 Feb 9;55(3):1368-81. DM965P4 RU https://pubmed.ncbi.nlm.nih.gov/22214363 DMFHR2O DI DMFHR2O DMFHR2O DN XR-1853 DMFHR2O MI TT5QA2I DMFHR2O MN Plasminogen activator inhibitor (PAI) DMFHR2O MT DTT DMFHR2O MA Modulator DMFHR2O RN Characterization and comparative evaluation of a novel PAI-1 inhibitor. Thromb Haemost. 2002 Jul;88(1):137-43. DMFHR2O RU https://pubmed.ncbi.nlm.nih.gov/12152654 DMJLRC7 DI DMJLRC7 DMJLRC7 DN XR-3005 DMJLRC7 MI TT7WZIJ DMJLRC7 MN CAAX farnesyltransferase beta (FNTB) DMJLRC7 MT DTT DMJLRC7 MA Modulator DMJLRC7 RN US patent application no. 2005,0227,929, Combination therapy comprising a cox-2 inhibitor and an antineoplastic agent. DMJLRC7 RU http://www.google.com/patents/US20050227929 DMXI39O DI DMXI39O DMXI39O DN XR-3054 DMXI39O MI TT7WZIJ DMXI39O MN CAAX farnesyltransferase beta (FNTB) DMXI39O MT DTT DMXI39O MA Inhibitor DMXI39O RN XR3054, structurally related to limonene, is a novel inhibitor of farnesyl protein transferase. Eur J Cancer. 1999 Jun;35(6):1014-9. DMXI39O RU https://pubmed.ncbi.nlm.nih.gov/10533487 DMX0PTO DI DMX0PTO DMX0PTO DN XR-368 DMX0PTO MI TTNJYV2 DMX0PTO MN Gamma-aminobutyric acid receptor (GAR) DMX0PTO MT DTT DMX0PTO MA Modulator DMX0PTO RN Regulation of neuronal and recombinant GABA(A) receptor ion channels by xenovulene A, a natural product isolated from Acremonium strictum. J Pharmacol Exp Ther. 1997 Aug;282(2):513-20. DMX0PTO RU https://pubmed.ncbi.nlm.nih.gov/9262310 DMEVSZO DI DMEVSZO DMEVSZO DN XR-5082 DMEVSZO MI TT5QA2I DMEVSZO MN Plasminogen activator inhibitor (PAI) DMEVSZO MT DTT DMEVSZO MA Inhibitor DMEVSZO RN Evaluation of a low molecular weight modulator of human plasminogen activator inhibitor-1 activity. Thromb Haemost. 1996 May;75(5):808-15. DMEVSZO RU https://pubmed.ncbi.nlm.nih.gov/8725728 DMA13OD DI DMA13OD DMA13OD DN XR-510 DMA13OD MI TT8DBY3 DMA13OD MN Angiotensin II receptor type-1 (AGTR1) DMA13OD MT DTT DMA13OD MA Modulator DMA13OD RN Pharmacology of XR510, a potent orally active nonpeptide angiotensin II AT1 receptor antagonist with high affinity for the AT2 receptor subtype. J Cardiovasc Pharmacol. 1995 Sep;26(3):354-62. DMA13OD RU https://pubmed.ncbi.nlm.nih.gov/8583775 DMIK72F DI DMIK72F DMIK72F DN XR-5118 DMIK72F MI TTTO43N DMIK72F MN Endothelial plasminogen activator inhibitor (SERPINE1) DMIK72F MT DTT DMIK72F MA Inhibitor DMIK72F RN Tiplaxtinin, a novel, orally efficacious inhibitor of plasminogen activator inhibitor-1: design, synthesis, and preclinical characterization. J Med Chem. 2004 Jul 1;47(14):3491-4. DMIK72F RU https://pubmed.ncbi.nlm.nih.gov/15214776 DM7TQYF DI DM7TQYF DM7TQYF DN Y-20024 DM7TQYF MI TTEX248 DM7TQYF MN Dopamine D2 receptor (D2R) DM7TQYF MT DTT DM7TQYF MA Agonist DM7TQYF RN Neuroleptic properties of Y-20024, a new benzofurancarboxamide derivative. Nihon Yakurigaku Zasshi. 1989 Nov;94(5):269-80. DM7TQYF RU https://pubmed.ncbi.nlm.nih.gov/2575566 DMLAVES DI DMLAVES DMLAVES DN Y-29794 DMLAVES MI TTNGKET DMLAVES MN Prolyl endopeptidase (PREP) DMLAVES MT DTT DMLAVES MA Inhibitor DMLAVES RN Inhibitors of prolyl oligopeptidases for the therapy of human diseases: defining diseases and inhibitors. J Med Chem. 2010 May 13;53(9):3423-38. DMLAVES RU https://pubmed.ncbi.nlm.nih.gov/20058865 DMG024B DI DMG024B DMG024B DN Y-931 DMG024B MI TTEX248 DMG024B MN Dopamine D2 receptor (D2R) DMG024B MT DTT DMG024B MA Binder DMG024B RN The pipeline and future of drug development in schizophrenia. Mol Psychiatry. 2007 Oct;12(10):904-22. DMG024B RU https://pubmed.ncbi.nlm.nih.gov/17667958 DM97ULM DI DM97ULM DM97ULM DN YM-022 DM97ULM MI TTVFO0U DM97ULM MN Gastrin/cholecystokinin type B receptor (CCKBR) DM97ULM MT DTT DM97ULM MA Antagonist DM97ULM RN YM022, a potent and selective gastrin/CCK-B receptor antagonist, inhibits peptone meal-induced gastric acid secretion in Heidenhain pouch dogs. Dig Dis Sci. 1997 Apr;42(4):707-14. DM97ULM RU https://pubmed.ncbi.nlm.nih.gov/9125636 DMDXLG2 DI DMDXLG2 DMDXLG2 DN YM-099 DMDXLG2 MI TT1VOHK DMDXLG2 MN Potassium channel unspecific (KC) DMDXLG2 MT DTT DMDXLG2 MA Opener DMDXLG2 RN Potassium channel-opening and vasorelaxant profiles of a novel compound YM099 in rat isolated portal vein and rabbit isolated aorta. Arch Int Pharmacodyn Ther. 1994 May-Jun;327(3):330-43. DMDXLG2 RU https://pubmed.ncbi.nlm.nih.gov/7848015 DMEHAI2 DI DMEHAI2 DMEHAI2 DN YM-26734 DMEHAI2 MI TT9V5JH DMEHAI2 MN Phospholipase A2 (PLA2G1B) DMEHAI2 MT DTT DMEHAI2 MA Modulator DMEHAI2 RN Simplified YM-26734 Inhibitors of Secreted Phospholipase A2 Group IIA DMEHAI2 RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2578825 DMWI094 DI DMWI094 DMWI094 DN YM-43611 DMWI094 MI TT4C8EA DMWI094 MN Dopamine D3 receptor (D3R) DMWI094 MT DTT DMWI094 MA Modulator DMWI094 RN Effects of YM-43611, a novel dopamine D2-like receptor antagonist, on immediate early gene expression in the rat forebrain. Neuropsychopharmacology. 1997 Jul;17(1):27-33. DMWI094 RU https://www.ncbi.nlm.nih.gov/pubmed/9194047 DMWI094 DI DMWI094 DMWI094 DN YM-43611 DMWI094 MI TTE0A2F DMWI094 MN Dopamine D4 receptor (D4R) DMWI094 MT DTT DMWI094 MA Modulator DMWI094 RN Effects of YM-43611, a novel dopamine D2-like receptor antagonist, on immediate early gene expression in the rat forebrain. Neuropsychopharmacology. 1997 Jul;17(1):27-33. DMWI094 RU https://www.ncbi.nlm.nih.gov/pubmed/9194047 DM7VGOC DI DM7VGOC DM7VGOC DN Ym60828 DM7VGOC MI TTCIHJA DM7VGOC MN Coagulation factor Xa (F10) DM7VGOC MT DTT DM7VGOC MA Inhibitor DM7VGOC RN Novel approaches to the treatment of thrombosis. Trends Pharmacol Sci. 2002 Jan;23(1):25-32. DM7VGOC RU https://pubmed.ncbi.nlm.nih.gov/11804648 DMK1UJM DI DMK1UJM DMK1UJM DN YP-004 DMK1UJM MI TTDB5IS DMK1UJM MN Receptor unspecific (Rec) DMK1UJM MT DTT DMK1UJM MA Inhibitor DMK1UJM RN CA patent application no. 815512, Method for increasing the efficiency of double-strand break-induced mutagenesis. DMK1UJM RU http://www.google.com/patents/CA2815512A1?cl=en DM2N76V DI DM2N76V DM2N76V DN YP-008 DM2N76V MI TT9B4N3 DM2N76V MN Prostaglandin receptor (PTGR) DM2N76V MT DTT DM2N76V MA Inhibitor DM2N76V RN CA patent application no. 841416, Method of selecting therapeutic indications. DM2N76V RU http://www.google.com/patents/CA2841416A1?cl=en DMPXLG2 DI DMPXLG2 DMPXLG2 DN YP-009 DMPXLG2 MI TT9B4N3 DMPXLG2 MN Prostaglandin receptor (PTGR) DMPXLG2 MT DTT DMPXLG2 MA Agonist DMPXLG2 RN YP 009 York Pharma pc preclinical, UK(cancer), R & D Focus Drug News, November 12, 2007 DMPXLG2 RU http://business.highbeam.com/436989/article-1G1-171156623/yp-009-york-pharma-pc-preclinical-uk DMQ6K8J DI DMQ6K8J DMQ6K8J DN Z-6568 DMQ6K8J MI TT5HONZ DMQ6K8J MN Calcium channel unspecific (CaC) DMQ6K8J MT DTT DMQ6K8J MA Modulator DMQ6K8J RN Determination of the dihydropyridine aryloxypropanolamine Z6568 and its acidic metabolites in plasma, urine and tissues by solid phase extraction and liquid chromatography/negative-ion mass spectrometry. J Mass Spectrom. 1996 Sep;31(9):994-1002. DMQ6K8J RU https://pubmed.ncbi.nlm.nih.gov/8831152 DMGH3T5 DI DMGH3T5 DMGH3T5 DN Zaprinast DMGH3T5 MI TTHQENC DMGH3T5 MN Phosphodiesterase 1 (PDE1) DMGH3T5 MT DTT DMGH3T5 MA Inhibitor DMGH3T5 RN The next generation of phosphodiesterase inhibitors: structural clues to ligand and substrate selectivity of phosphodiesterases. J Med Chem. 2005 May 19;48(10):3449-62. DMGH3T5 RU https://pubmed.ncbi.nlm.nih.gov/15887951 DMGH3T5 DI DMGH3T5 DMGH3T5 DN Zaprinast DMGH3T5 MI TTSKMI8 DMGH3T5 MN Phosphodiesterase 4D (PDE4D) DMGH3T5 MT DTT DMGH3T5 MA Inhibitor DMGH3T5 RN 8-Substituted analogues of 3-(3-cyclopentyloxy-4-methoxy-benzyl)-8-isopropyl-adenine: highly potent and selective PDE4 inhibitors. J Med Chem. 2005 Feb 24;48(4):1237-43. DMGH3T5 RU https://pubmed.ncbi.nlm.nih.gov/15715490 DMGH3T5 DI DMGH3T5 DMGH3T5 DN Zaprinast DMGH3T5 MI TTJ0IQB DMGH3T5 MN Phosphodiesterase 5A (PDE5A) DMGH3T5 MT DTT DMGH3T5 MA Inhibitor DMGH3T5 RN 4-(3-Chloro-4-methoxybenzyl)aminophthalazines: synthesis and inhibitory activity toward phosphodiesterase 5. J Med Chem. 2000 Jun 29;43(13):2523-9. DMGH3T5 RU https://pubmed.ncbi.nlm.nih.gov/10891111 DMC38FO DI DMC38FO DMC38FO DN ZARDAVERINE DMC38FO MI TTZCG4L DMC38FO MN Phosphodiesterase 3 (PDE3) DMC38FO MT DTT DMC38FO MA Modulator DMC38FO RN Zardaverine: a cyclic AMP specific PDE III/IV inhibitor.Agents Actions Suppl.1991;34:379-402. DMC38FO RU https://www.ncbi.nlm.nih.gov/pubmed/1665311 DMNYKOT DI DMNYKOT DMNYKOT DN Zatebradine DMNYKOT MI TTW0CMT DMNYKOT MN Voltage-gated potassium channel Kv1.5 (KCNA5) DMNYKOT MT DTT DMNYKOT MA Modulator DMNYKOT RN DOI: 10.1161/01.CIR.94.3.562 DMNYKOT RU http://circ.ahajournals.org/content/94/3/562.abstract DM6M9GC DI DM6M9GC DM6M9GC DN ZD-3638 DM6M9GC MI TTJQOD7 DM6M9GC MN 5-HT 2A receptor (HTR2A) DM6M9GC MT DTT DM6M9GC MA Binder DM6M9GC RN The pipeline and future of drug development in schizophrenia. Mol Psychiatry. 2007 Oct;12(10):904-22. DM6M9GC RU https://pubmed.ncbi.nlm.nih.gov/17667958 DM6M9GC DI DM6M9GC DM6M9GC DN ZD-3638 DM6M9GC MI TTEX248 DM6M9GC MN Dopamine D2 receptor (D2R) DM6M9GC MT DTT DM6M9GC MA Binder DM6M9GC RN The pipeline and future of drug development in schizophrenia. Mol Psychiatry. 2007 Oct;12(10):904-22. DM6M9GC RU https://pubmed.ncbi.nlm.nih.gov/17667958 DM6M9GC DI DM6M9GC DM6M9GC DN ZD-3638 DM6M9GC MI TTS2PH3 DM6M9GC MN Dopamine D5 receptor (D5R) DM6M9GC MT DTT DM6M9GC MA Binder DM6M9GC RN The pipeline and future of drug development in schizophrenia. Mol Psychiatry. 2007 Oct;12(10):904-22. DM6M9GC RU https://pubmed.ncbi.nlm.nih.gov/17667958 DM91IPH DI DM91IPH DM91IPH DN ZD-3980 DM91IPH MI TTS64P2 DM91IPH MN Androgen receptor (AR) DM91IPH MT DTT DM91IPH MA Modulator DM91IPH RN Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800009538) DM91IPH RU http://adisinsight.springer.com/drugs/800009538 DMVWRU9 DI DMVWRU9 DMVWRU9 DN ZD-4190 DMVWRU9 MI TTVJ1D8 DMVWRU9 MN Vascular endothelial growth factor receptor (VEGFR) DMVWRU9 MT DTT DMVWRU9 MA Modulator DMVWRU9 RN ZD4190: an orally active inhibitor of vascular endothelial growth factor signaling with broad-spectrum antitumor efficacy. Cancer Res. 2000 Feb 15;60(4):970-5. DMVWRU9 RU https://pubmed.ncbi.nlm.nih.gov/10706112 DMU2F6Q DI DMU2F6Q DMU2F6Q DN ZD-6003 DMU2F6Q MI TTC70AJ DMU2F6Q MN Granulocyte colony-stimulating factor receptor (G-CSF-R) DMU2F6Q MT DTT DMU2F6Q MA Modulator DMU2F6Q RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1719). DMU2F6Q RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1719 DM5KSCI DI DM5KSCI DM5KSCI DN ZD-7155 DM5KSCI MI TTGN1ZA DM5KSCI MN Angiotensin II receptor (AGTR) DM5KSCI MT DTT DM5KSCI MA Modulator DM5KSCI RN Comparative cardiovascular effects of the angiotensin II type 1 receptor antagonists ZD 7155 and losartan in the rat. J Pharm Pharmacol. 1996 Aug;48(8):829-33. DM5KSCI RU https://pubmed.ncbi.nlm.nih.gov/8887734 DMJEZOP DI DMJEZOP DMJEZOP DN ZD-7717 DMJEZOP MI TT2J34L DMJEZOP MN Arachidonate 5-lipoxygenase (5-LOX) DMJEZOP MT DTT DMJEZOP MA Modulator DMJEZOP RN CA patent application no. 445634, Acne treatment comprising lipoxygenase inhibitors. DMJEZOP RU http://www.google.hr/patents/CA2445634A1?cl=en&hl=hr DMCT1IX DI DMCT1IX DMCT1IX DN ZD-7944 DMCT1IX MI TTYO0A3 DMCT1IX MN Substance-K receptor (TACR2) DMCT1IX MT DTT DMCT1IX MA Modulator DMCT1IX RN Discovery of novel, orally active dual NK1/NK2 antagonists. Bioorg Med Chem Lett. 2001 Oct 22;11(20):2769-73. DMCT1IX RU https://pubmed.ncbi.nlm.nih.gov/11591520 DMFV47R DI DMFV47R DMFV47R DN ZD-9720 DMFV47R MI TT7O8ZA DMFV47R MN Lanosterol synthase (LSS) DMFV47R MT DTT DMFV47R MA Modulator DMFV47R RN Toxicologic lesions associated with two related inhibitors of oxidosqualene cyclase in the dog and mouse. Toxicol Pathol. 2001 Mar-Apr;29(2):174-9. DMFV47R RU https://pubmed.ncbi.nlm.nih.gov/11421484 DMQUSG9 DI DMQUSG9 DMQUSG9 DN Zenarestat DMQUSG9 MI TTFBNVI DMQUSG9 MN Aldose reductase (AKR1B1) DMQUSG9 MT DTT DMQUSG9 MA Inhibitor DMQUSG9 RN The effects of zenarestat, an aldose reductase inhibitor, on minimal F-wave latency and nerve blood flow in streptozotocin-induced diabetic rats. Life Sci. 2001 Feb 9;68(12):1439-48. DMQUSG9 RU https://pubmed.ncbi.nlm.nih.gov/11388695 DM81DJV DI DM81DJV DM81DJV DN Zindoxifene DM81DJV MI TTZAYWL DM81DJV MN Estrogen receptor (ESR) DM81DJV MT DTT DM81DJV MA Modulator DM81DJV RN Phase I/II study of the anti-oestrogen zindoxifene (D16726) in the treatment of advanced breast cancer. A Cancer Research Campaign Phase I/II Clinical Trials Committee study.. Br J Cancer. 1990 March; 61(3): 451-453. DM81DJV RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1971274/ DMJZH7N DI DMJZH7N DMJZH7N DN ZK-118182 DMJZH7N MI TTNVEIR DMJZH7N MN Prostaglandin D2 receptor (PTGDR) DMJZH7N MT DTT DMJZH7N MA Modulator DMJZH7N RN Characterization of prostanoid receptors mediating inhibition of histamine release from anti-IgE-activated rat peritoneal mast cells. Br J Pharmacol. 2000 Feb;129(3):589-97. DMJZH7N RU https://pubmed.ncbi.nlm.nih.gov/10711359 DMKFYDE DI DMKFYDE DMKFYDE DN ZK-119010 DMKFYDE MI TTZAYWL DMKFYDE MN Estrogen receptor (ESR) DMKFYDE MT DTT DMKFYDE MA Inhibitor DMKFYDE RN 2-Phenylindole-linked [2-(aminoalkyl)pyridine]dichloroplatinum(II): complexes with a selective action on estrogen receptor positive mammary tumors. J Med Chem. 1991 Jul;34(7):2145-52. DMKFYDE RU https://pubmed.ncbi.nlm.nih.gov/2066987 DMKFYDE DI DMKFYDE DMKFYDE DN ZK-119010 DMKFYDE MI TTOM3J0 DMKFYDE MN Estrogen receptor beta (ESR2) DMKFYDE MT DTT DMKFYDE MA Inhibitor DMKFYDE RN 2-Phenylindole-linked [2-(aminoalkyl)pyridine]dichloroplatinum(II): complexes with a selective action on estrogen receptor positive mammary tumors. J Med Chem. 1991 Jul;34(7):2145-52. DMKFYDE RU https://pubmed.ncbi.nlm.nih.gov/2066987 DMJYIVA DI DMJYIVA DMJYIVA DN ZK-91296 DMJYIVA MI TTEX6LM DMJYIVA MN GABA(A) receptor gamma-3 (GABRG3) DMJYIVA MT DTT DMJYIVA MA Modulator DMJYIVA RN Enhancement of gamma-aminobutyric acid binding by the anxiolytic beta-carbolines ZK 93423 and ZK 91296. J Neurochem. 1987 May;48(5):1355-8. DMJYIVA RU https://www.ncbi.nlm.nih.gov/pubmed/2881979 DMMDQ5T DI DMMDQ5T DMMDQ5T DN ZK-93426 DMMDQ5T MI TTEX6LM DMMDQ5T MN GABA(A) receptor gamma-3 (GABRG3) DMMDQ5T MT DTT DMMDQ5T MA Modulator DMMDQ5T RN Actions of the beta-carboline ZK 93426 in an animal test of anxiety and the holeboard: interactions with Ro 15-1788. J Neural Transm. 1986;65(2):103-14. DMMDQ5T RU https://www.ncbi.nlm.nih.gov/pubmed/3009709 DM8V0YA DI DM8V0YA DM8V0YA DN ZM-224832 DM8V0YA MI TT5HONZ DM8V0YA MN Calcium channel unspecific (CaC) DM8V0YA MT DTT DM8V0YA MA Modulator DM8V0YA RN Diuretic and antihypertensive activity of ZENECA ZM224,832: a novel eukalemic diuretic with calcium channel blocking activity. Pharmacology. 1994 Mar;48(3):167-75. DM8V0YA RU https://pubmed.ncbi.nlm.nih.gov/8153144 DM0TBQK DI DM0TBQK DM0TBQK DN ZM-230487 DM0TBQK MI TT2J34L DM0TBQK MN Arachidonate 5-lipoxygenase (5-LOX) DM0TBQK MT DTT DM0TBQK MA Inhibitor DM0TBQK RN Pharmacological nature of nicotine-induced contraction in the rat basilar artery: involvement of arachidonic acid metabolites. Eur J Pharmacol. 2007 Dec 22;577(1-3):109-14. DM0TBQK RU https://pubmed.ncbi.nlm.nih.gov/17765890 DMWQ38G DI DMWQ38G DMWQ38G DN ZM-241385 DMWQ38G MI TTK25J1 DMWQ38G MN Adenosine A1 receptor (ADORA1) DMWQ38G MT DTT DMWQ38G MA Inhibitor DMWQ38G RN 2-Phenylpyrazolo[4,3-d]pyrimidin-7-one as a new scaffold to obtain potent and selective human A3 adenosine receptor antagonists: new insights into ... J Med Chem. 2009 Dec 10;52(23):7640-52. DMWQ38G RU https://pubmed.ncbi.nlm.nih.gov/19743865 DMWQ38G DI DMWQ38G DMWQ38G DN ZM-241385 DMWQ38G MI TTM2AOE DMWQ38G MN Adenosine A2a receptor (ADORA2A) DMWQ38G MT DTT DMWQ38G MA Inhibitor DMWQ38G RN 2-Phenylpyrazolo[4,3-d]pyrimidin-7-one as a new scaffold to obtain potent and selective human A3 adenosine receptor antagonists: new insights into ... J Med Chem. 2009 Dec 10;52(23):7640-52. DMWQ38G RU https://pubmed.ncbi.nlm.nih.gov/19743865 DMWQ38G DI DMWQ38G DMWQ38G DN ZM-241385 DMWQ38G MI TTNE7KG DMWQ38G MN Adenosine A2b receptor (ADORA2B) DMWQ38G MT DTT DMWQ38G MA Inhibitor DMWQ38G RN Synthesis of theophylline derivatives and study of their activity as antagonists at adenosine receptors. Bioorg Med Chem. 2010 Mar 15;18(6):2081-2088. DMWQ38G RU https://pubmed.ncbi.nlm.nih.gov/20202853 DM70HZD DI DM70HZD DM70HZD DN Zonampanel DM70HZD MI TTAN6JD DM70HZD MN Glutamate receptor AMPA (GRIA) DM70HZD MT DTT DM70HZD MA Inhibitor DM70HZD RN Synthesis and AMPA receptor antagonistic activity of a novel 7-imidazolyl-6-trifluoromethyl quinoxalinecarboxylic acid with a substituted phenyl gr... Bioorg Med Chem Lett. 2004 Oct 18;14(20):5107-11. DM70HZD RU https://pubmed.ncbi.nlm.nih.gov/15380209 DM70HZD DI DM70HZD DM70HZD DN Zonampanel DM70HZD MI TTVPQTF DM70HZD MN Glutamate receptor AMPA 1 (GRIA1) DM70HZD MT DTT DM70HZD MA Inhibitor DM70HZD RN Synthesis and AMPA receptor antagonistic activity of a novel 7-imidazolyl-6-trifluoromethyl quinoxalinecarboxylic acid with a substituted phenyl gr... Bioorg Med Chem Lett. 2004 Oct 18;14(20):5107-11. DM70HZD RU https://pubmed.ncbi.nlm.nih.gov/15380209 DM70TKB DI DM70TKB DM70TKB DN zoxazolamine DM70TKB MI TT2T5M0 DM70TKB MN Calcium-activated potassium channel KCa2.2 (KCNN2) DM70TKB MT DTT DM70TKB MA Activator DM70TKB RN Modulation of recombinant small-conductance Ca(2+)-activated K(+) channels by the muscle relaxant chlorzoxazone and structurally related compounds. J Pharmacol Exp Ther. 2001 Mar;296(3):683-9. DM70TKB RU https://pubmed.ncbi.nlm.nih.gov/11181893 DM193WR DI DM193WR DM193WR DN ZT-386 DM193WR MI TT2O84V DM193WR MN Thromboxane A2 receptor (TBXA2R) DM193WR MT DTT DM193WR MA Modulator DM193WR RN Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800004057) DM193WR RU http://adisinsight.springer.com/drugs/800004057 DM2TIU3 DI DM2TIU3 DM2TIU3 DN ((3R,4R)-4-(o-tolyloxy)chroman-3-yl)methanamine DM2TIU3 MI TTAWNKZ DM2TIU3 MN Norepinephrine transporter (NET) DM2TIU3 MT DTT DM2TIU3 MA Inhibitor DM2TIU3 RN Synthesis and structure-activity relationships of selective norepinephrine reuptake inhibitors (sNRI) with a heterocyclic ring constraint. Bioorg Med Chem Lett. 2008 Aug 15;18(16):4495-8. DM2TIU3 RU https://pubmed.ncbi.nlm.nih.gov/18667309 DM2TIU3 DI DM2TIU3 DM2TIU3 DN ((3R,4R)-4-(o-tolyloxy)chroman-3-yl)methanamine DM2TIU3 MI TT3ROYC DM2TIU3 MN Serotonin transporter (SERT) DM2TIU3 MT DTT DM2TIU3 MA Inhibitor DM2TIU3 RN Synthesis and structure-activity relationships of selective norepinephrine reuptake inhibitors (sNRI) with a heterocyclic ring constraint. Bioorg Med Chem Lett. 2008 Aug 15;18(16):4495-8. DM2TIU3 RU https://pubmed.ncbi.nlm.nih.gov/18667309 DMEJRVW DI DMEJRVW DMEJRVW DN ((E)-3-Amino-propenyl)-methyl-phosphinic acid DMEJRVW MI TTDCVZW DMEJRVW MN Gamma-aminobutyric acid B receptor (GABBR) DMEJRVW MT DTT DMEJRVW MA Inhibitor DMEJRVW RN Phosphinic acid analogues of GABA. 1. New potent and selective GABAB agonists. J Med Chem. 1995 Aug 18;38(17):3297-312. DMEJRVW RU https://pubmed.ncbi.nlm.nih.gov/7650684 DMEJRVW DI DMEJRVW DMEJRVW DN ((E)-3-Amino-propenyl)-methyl-phosphinic acid DMEJRVW MI TTNJYV2 DMEJRVW MN Gamma-aminobutyric acid receptor (GAR) DMEJRVW MT DTT DMEJRVW MA Inhibitor DMEJRVW RN Novel gamma-aminobutyric acid rho1 receptor antagonists; synthesis, pharmacological activity and structure-activity relationships. J Med Chem. 2008 Jul 10;51(13):3825-40. DMEJRVW RU https://pubmed.ncbi.nlm.nih.gov/18528996 DMCW65Q DI DMCW65Q DMCW65Q DN ((E)-7-But-2-enyl)-azepan-(2Z)-ylideneamine DMCW65Q MI TTZUFI5 DMCW65Q MN Nitric-oxide synthase brain (NOS1) DMCW65Q MT DTT DMCW65Q MA Inhibitor DMCW65Q RN Selective heterocyclic amidine inhibitors of human inducible nitric oxide synthase. Bioorg Med Chem Lett. 2001 Oct 8;11(19):2651-3. DMCW65Q RU https://pubmed.ncbi.nlm.nih.gov/11551770 DMCW65Q DI DMCW65Q DMCW65Q DN ((E)-7-But-2-enyl)-azepan-(2Z)-ylideneamine DMCW65Q MI TTF10I9 DMCW65Q MN Nitric-oxide synthase inducible (NOS2) DMCW65Q MT DTT DMCW65Q MA Inhibitor DMCW65Q RN Selective heterocyclic amidine inhibitors of human inducible nitric oxide synthase. Bioorg Med Chem Lett. 2001 Oct 8;11(19):2651-3. DMCW65Q RU https://pubmed.ncbi.nlm.nih.gov/11551770 DM6H0FW DI DM6H0FW DM6H0FW DN ((Z)-3-Amino-propenyl)-methyl-phosphinic acid DM6H0FW MI TTDCVZW DM6H0FW MN Gamma-aminobutyric acid B receptor (GABBR) DM6H0FW MT DTT DM6H0FW MA Inhibitor DM6H0FW RN Phosphinic acid analogues of GABA. 1. New potent and selective GABAB agonists. J Med Chem. 1995 Aug 18;38(17):3297-312. DM6H0FW RU https://pubmed.ncbi.nlm.nih.gov/7650684 DM974LP DI DM974LP DM974LP DN (-)-(1S,1'R)-O,O-dimethylgrisbine hydrochloride DM974LP MI TTZFYLI DM974LP MN Dopamine D1 receptor (D1R) DM974LP MT DTT DM974LP MA Inhibitor DM974LP RN Displacement activity of bisbenzylisoquinoline alkaloids at striatal 3H-SCH 23390 and 3H-raclopride binding sites. J Nat Prod. 1992 Sep;55(9):1281-6. DM974LP RU https://pubmed.ncbi.nlm.nih.gov/1431946 DM974LP DI DM974LP DM974LP DN (-)-(1S,1'R)-O,O-dimethylgrisbine hydrochloride DM974LP MI TTEX248 DM974LP MN Dopamine D2 receptor (D2R) DM974LP MT DTT DM974LP MA Inhibitor DM974LP RN Displacement activity of bisbenzylisoquinoline alkaloids at striatal 3H-SCH 23390 and 3H-raclopride binding sites. J Nat Prod. 1992 Sep;55(9):1281-6. DM974LP RU https://pubmed.ncbi.nlm.nih.gov/1431946 DMV6EMN DI DMV6EMN DMV6EMN DN (-)-(R)-efonidipine DMV6EMN MI TTZIFHC DMV6EMN MN Voltage-gated calcium channel alpha Cav1.2 (CACNA1C) DMV6EMN MT DTT DMV6EMN MA Blocker (channel blocker) DMV6EMN RN Identification of R(-)-isomer of efonidipine as a selective blocker of T-type Ca2+ channels. Br J Pharmacol. 2004 Dec;143(8):1050-7. DMV6EMN RU https://pubmed.ncbi.nlm.nih.gov/15545287 DMV6EMN DI DMV6EMN DMV6EMN DN (-)-(R)-efonidipine DMV6EMN MI TT729IR DMV6EMN MN Voltage-gated calcium channel alpha Cav3.1 (CACNA1G) DMV6EMN MT DTT DMV6EMN MA Blocker (channel blocker) DMV6EMN RN Identification of R(-)-isomer of efonidipine as a selective blocker of T-type Ca2+ channels. Br J Pharmacol. 2004 Dec;143(8):1050-7. DMV6EMN RU https://pubmed.ncbi.nlm.nih.gov/15545287 DMEA9KH DI DMEA9KH DMEA9KH DN (-)-(S)-BayK8644 DMEA9KH MI TT94HRF DMEA9KH MN Voltage-gated calcium channel alpha Cav1.1 (CACNA1S) DMEA9KH MT DTT DMEA9KH MA Activator DMEA9KH RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 528). DMEA9KH RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=528 DMEA9KH DI DMEA9KH DMEA9KH DN (-)-(S)-BayK8644 DMEA9KH MI TTZIFHC DMEA9KH MN Voltage-gated calcium channel alpha Cav1.2 (CACNA1C) DMEA9KH MT DTT DMEA9KH MA Activator DMEA9KH RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 529). DMEA9KH RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=529 DMEA9KH DI DMEA9KH DMEA9KH DN (-)-(S)-BayK8644 DMEA9KH MI TT7RGTM DMEA9KH MN Voltage-gated calcium channel alpha Cav1.3 (CACNA1D) DMEA9KH MT DTT DMEA9KH MA Activator DMEA9KH RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 530). DMEA9KH RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=530 DMEA9KH DI DMEA9KH DMEA9KH DN (-)-(S)-BayK8644 DMEA9KH MI TTJ0SO4 DMEA9KH MN Voltage-gated calcium channel alpha Cav1.4 (CACNA1F) DMEA9KH MT DTT DMEA9KH MA Activator DMEA9KH RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 531). DMEA9KH RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=531 DME5TIR DI DME5TIR DME5TIR DN (-)-3-(1-Propyl-piperidin-3-yl)-benzonitrile DME5TIR MI TTEX248 DME5TIR MN Dopamine D2 receptor (D2R) DME5TIR MT DTT DME5TIR MA Inhibitor DME5TIR RN Substituted 3-phenylpiperidines: new centrally acting dopamine autoreceptor antagonists. J Med Chem. 1993 Oct 15;36(21):3188-96. DME5TIR RU https://pubmed.ncbi.nlm.nih.gov/8230107 DME5TIR DI DME5TIR DME5TIR DN (-)-3-(1-Propyl-piperidin-3-yl)-benzonitrile DME5TIR MI TT4C8EA DME5TIR MN Dopamine D3 receptor (D3R) DME5TIR MT DTT DME5TIR MA Inhibitor DME5TIR RN Substituted 3-phenylpiperidines: new centrally acting dopamine autoreceptor antagonists. J Med Chem. 1993 Oct 15;36(21):3188-96. DME5TIR RU https://pubmed.ncbi.nlm.nih.gov/8230107 DMGC7F5 DI DMGC7F5 DMGC7F5 DN (-)-3,3'-bisdemethylpinoresinol DMGC7F5 MI TTN9T81 DMGC7F5 MN Arachidonate 15-lipoxygenase (15-LOX) DMGC7F5 MT DTT DMGC7F5 MA Inhibitor DMGC7F5 RN Lipoxygenase inhibitory constituents of the fruits of noni (Morinda citrifolia) collected in Tahiti. J Nat Prod. 2007 May;70(5):859-62. DMGC7F5 RU https://pubmed.ncbi.nlm.nih.gov/17378609 DMGC7F5 DI DMGC7F5 DMGC7F5 DN (-)-3,3'-bisdemethylpinoresinol DMGC7F5 MI TTSJ6Q4 DMGC7F5 MN LOX-5 messenger RNA (ALOX5 mRNA) DMGC7F5 MT DTT DMGC7F5 MA Inhibitor DMGC7F5 RN Lipoxygenase inhibitory constituents of the fruits of noni (Morinda citrifolia) collected in Tahiti. J Nat Prod. 2007 May;70(5):859-62. DMGC7F5 RU https://pubmed.ncbi.nlm.nih.gov/17378609 DMKRTBM DI DMKRTBM DMKRTBM DN (-)-3-O-acetylspectaline DMKRTBM MI TT8NGED DMKRTBM MN Prostaglandin G/H synthase 1 (COX-1) DMKRTBM MT DTT DMKRTBM MA Inhibitor DMKRTBM RN Lipoperoxidation and cyclooxygenase enzyme inhibitory piperidine alkaloids from Cassia spectabilis green fruits. J Nat Prod. 2007 Dec;70(12):2026-8. DMKRTBM RU https://pubmed.ncbi.nlm.nih.gov/18047293 DM396OK DI DM396OK DM396OK DN (-)-7-N-methyldibromophakellin DM396OK MI TT12ABZ DM396OK MN Arachidonate 12-lipoxygenase (12-LOX) DM396OK MT DTT DM396OK MA Inhibitor DM396OK RN An analysis of phakellin and oroidin structures stimulated by further study of an Agelas sponge. J Nat Prod. 2004 Aug;67(8):1256-61. DM396OK RU https://pubmed.ncbi.nlm.nih.gov/15332838 DMZOGSK DI DMZOGSK DMZOGSK DN (-)-CATECHINGALLATE DMZOGSK MI TT8JRS7 DMZOGSK MN Beta-secretase (BACE) DMZOGSK MT DTT DMZOGSK MA Inhibitor DMZOGSK RN Green tea catechins as a BACE1 (beta-secretase) inhibitor. Bioorg Med Chem Lett. 2003 Nov 17;13(22):3905-8. DMZOGSK RU https://pubmed.ncbi.nlm.nih.gov/14592472 DMZOGSK DI DMZOGSK DMZOGSK DN (-)-CATECHINGALLATE DMZOGSK MI TT7AOUD DMZOGSK MN Fatty acid synthase (FASN) DMZOGSK MT DTT DMZOGSK MA Inhibitor DMZOGSK RN Inhibition of Plasmodium falciparum fatty acid biosynthesis: evaluation of FabG, FabZ, and FabI as drug targets for flavonoids. J Med Chem. 2006 Jun 1;49(11):3345-53. DMZOGSK RU https://pubmed.ncbi.nlm.nih.gov/16722653 DMZOGSK DI DMZOGSK DMZOGSK DN (-)-CATECHINGALLATE DMZOGSK MI TTHPFTS DMZOGSK MN Plasmodium Beta-hydroxyacyl-ACP dehydratase (Malaria FabZ) DMZOGSK MT DTT DMZOGSK MA Inhibitor DMZOGSK RN Inhibition of Plasmodium falciparum fatty acid biosynthesis: evaluation of FabG, FabZ, and FabI as drug targets for flavonoids. J Med Chem. 2006 Jun 1;49(11):3345-53. DMZOGSK RU https://pubmed.ncbi.nlm.nih.gov/16722653 DMZOGSK DI DMZOGSK DMZOGSK DN (-)-CATECHINGALLATE DMZOGSK MI TTNX2CS DMZOGSK MN Plasmodium Enoyl-ACP reductase (Malaria fabI) DMZOGSK MT DTT DMZOGSK MA Inhibitor DMZOGSK RN Inhibition of Plasmodium falciparum fatty acid biosynthesis: evaluation of FabG, FabZ, and FabI as drug targets for flavonoids. J Med Chem. 2006 Jun 1;49(11):3345-53. DMZOGSK RU https://pubmed.ncbi.nlm.nih.gov/16722653 DMZOGSK DI DMZOGSK DMZOGSK DN (-)-CATECHINGALLATE DMZOGSK MI TTBE4IR DMZOGSK MN Plasmodium Oxoacyl-[acyl-carrier protein] reductase (Malaria fabG) DMZOGSK MT DTT DMZOGSK MA Inhibitor DMZOGSK RN Inhibition of Plasmodium falciparum fatty acid biosynthesis: evaluation of FabG, FabZ, and FabI as drug targets for flavonoids. J Med Chem. 2006 Jun 1;49(11):3345-53. DMZOGSK RU https://pubmed.ncbi.nlm.nih.gov/16722653 DMJ249P DI DMJ249P DMJ249P DN (-)-Cercosporamide DMJ249P MI TTFJ8Q1 DMJ249P MN Protein kinase C alpha (PRKCA) DMJ249P MT DTT DMJ249P MA Inhibitor DMJ249P RN (-)-Cercosporamide derivatives as novel antihyperglycemic agents. Bioorg Med Chem Lett. 2009 Feb 1;19(3):724-6. DMJ249P RU https://pubmed.ncbi.nlm.nih.gov/19109017 DMJ249P DI DMJ249P DMJ249P DN (-)-Cercosporamide DMJ249P MI TTYPXQF DMJ249P MN Protein kinase C beta (PRKCB) DMJ249P MT DTT DMJ249P MA Inhibitor DMJ249P RN (-)-Cercosporamide derivatives as novel antihyperglycemic agents. Bioorg Med Chem Lett. 2009 Feb 1;19(3):724-6. DMJ249P RU https://pubmed.ncbi.nlm.nih.gov/19109017 DMJ249P DI DMJ249P DMJ249P DN (-)-Cercosporamide DMJ249P MI TTRFOXJ DMJ249P MN Protein kinase C gamma (PRKCG) DMJ249P MT DTT DMJ249P MA Inhibitor DMJ249P RN (-)-Cercosporamide derivatives as novel antihyperglycemic agents. Bioorg Med Chem Lett. 2009 Feb 1;19(3):724-6. DMJ249P RU https://pubmed.ncbi.nlm.nih.gov/19109017 DMPGJE6 DI DMPGJE6 DMPGJE6 DN (-)-clusin DMPGJE6 MI TTXV4FI DMPGJE6 MN Albendazole monooxygenase (CYP3A4) DMPGJE6 MT DTT DMPGJE6 MA Inhibitor DMPGJE6 RN Potent CYP3A4 inhibitory constituents of Piper cubeba. J Nat Prod. 2005 Jan;68(1):64-8. DMPGJE6 RU https://pubmed.ncbi.nlm.nih.gov/15679319 DM57LVW DI DM57LVW DM57LVW DN (-)-cubebin DM57LVW MI TTXV4FI DM57LVW MN Albendazole monooxygenase (CYP3A4) DM57LVW MT DTT DM57LVW MA Inhibitor DM57LVW RN Potent CYP3A4 inhibitory constituents of Piper cubeba. J Nat Prod. 2005 Jan;68(1):64-8. DM57LVW RU https://pubmed.ncbi.nlm.nih.gov/15679319 DMSTZF9 DI DMSTZF9 DMSTZF9 DN (-)-cubebinin DMSTZF9 MI TTXV4FI DMSTZF9 MN Albendazole monooxygenase (CYP3A4) DMSTZF9 MT DTT DMSTZF9 MA Inhibitor DMSTZF9 RN Potent CYP3A4 inhibitory constituents of Piper cubeba. J Nat Prod. 2005 Jan;68(1):64-8. DMSTZF9 RU https://pubmed.ncbi.nlm.nih.gov/15679319 DM8Q6I0 DI DM8Q6I0 DM8Q6I0 DN (-)-cubebininolide DM8Q6I0 MI TTXV4FI DM8Q6I0 MN Albendazole monooxygenase (CYP3A4) DM8Q6I0 MT DTT DM8Q6I0 MA Inhibitor DM8Q6I0 RN Potent CYP3A4 inhibitory constituents of Piper cubeba. J Nat Prod. 2005 Jan;68(1):64-8. DM8Q6I0 RU https://pubmed.ncbi.nlm.nih.gov/15679319 DMC8WS4 DI DMC8WS4 DMC8WS4 DN (-)-cyclorphan DMC8WS4 MI TT27RFC DMC8WS4 MN Opioid receptor delta (OPRD1) DMC8WS4 MT DTT DMC8WS4 MA Inhibitor DMC8WS4 RN Synthesis and preliminary in vitro investigation of bivalent ligands containing homo- and heterodimeric pharmacophores at mu, delta, and kappa opio... J Med Chem. 2006 Jan 12;49(1):256-62. DMC8WS4 RU https://pubmed.ncbi.nlm.nih.gov/16392810 DMC8WS4 DI DMC8WS4 DMC8WS4 DN (-)-cyclorphan DMC8WS4 MI TTQW87Y DMC8WS4 MN Opioid receptor kappa (OPRK1) DMC8WS4 MT DTT DMC8WS4 MA Inhibitor DMC8WS4 RN Synthesis and preliminary in vitro investigation of bivalent ligands containing homo- and heterodimeric pharmacophores at mu, delta, and kappa opio... J Med Chem. 2006 Jan 12;49(1):256-62. DMC8WS4 RU https://pubmed.ncbi.nlm.nih.gov/16392810 DMC8WS4 DI DMC8WS4 DMC8WS4 DN (-)-cyclorphan DMC8WS4 MI TTKWM86 DMC8WS4 MN Opioid receptor mu (MOP) DMC8WS4 MT DTT DMC8WS4 MA Inhibitor DMC8WS4 RN Synthesis and preliminary in vitro investigation of bivalent ligands containing homo- and heterodimeric pharmacophores at mu, delta, and kappa opio... J Med Chem. 2006 Jan 12;49(1):256-62. DMC8WS4 RU https://pubmed.ncbi.nlm.nih.gov/16392810 DM6LGHU DI DM6LGHU DM6LGHU DN (-)-DEBROMOFLUSTRAMINE B DM6LGHU MI TTEB0GD DM6LGHU MN Cholinesterase (BCHE) DM6LGHU MT DTT DM6LGHU MA Inhibitor DM6LGHU RN Synthesis and biological evaluation of (-)- and (+)-debromoflustramine B and its analogues as selective butyrylcholinesterase inhibitors. J Med Chem. 2008 Sep 11;51(17):5271-84. DM6LGHU RU https://pubmed.ncbi.nlm.nih.gov/18686941 DMNYH3X DI DMNYH3X DMNYH3X DN (-)-dihydroclusin DMNYH3X MI TTXV4FI DMNYH3X MN Albendazole monooxygenase (CYP3A4) DMNYH3X MT DTT DMNYH3X MA Inhibitor DMNYH3X RN Potent CYP3A4 inhibitory constituents of Piper cubeba. J Nat Prod. 2005 Jan;68(1):64-8. DMNYH3X RU https://pubmed.ncbi.nlm.nih.gov/15679319 DMPQBWY DI DMPQBWY DMPQBWY DN (-)-englerin A DMPQBWY MI TTX0H5W DMPQBWY MN Short transient receptor potential channel 4 (TRPC4) DMPQBWY MT DTT DMPQBWY MA Agonist DMPQBWY RN (-)-Englerin is a potent and selective activator of TRPC4 and TRPC5 calcium channels. Angew Chem Int Ed Engl. 2015 Mar 16;54(12):3787-91. DMPQBWY RU https://pubmed.ncbi.nlm.nih.gov/25707820 DMPQBWY DI DMPQBWY DMPQBWY DN (-)-englerin A DMPQBWY MI TT32NQ1 DMPQBWY MN Short transient receptor potential channel 5 (TRPC5) DMPQBWY MT DTT DMPQBWY MA Agonist DMPQBWY RN (-)-Englerin is a potent and selective activator of TRPC4 and TRPC5 calcium channels. Angew Chem Int Ed Engl. 2015 Mar 16;54(12):3787-91. DMPQBWY RU https://pubmed.ncbi.nlm.nih.gov/25707820 DMJD34Q DI DMJD34Q DMJD34Q DN (-)-eseroline DMJD34Q MI TT27RFC DMJD34Q MN Opioid receptor delta (OPRD1) DMJD34Q MT DTT DMJD34Q MA Inhibitor DMJD34Q RN Akuammine and dihydroakuammine, two indolomonoterpene alkaloids displaying affinity for opioid receptors. J Nat Prod. 1992 Mar;55(3):380-4. DMJD34Q RU https://pubmed.ncbi.nlm.nih.gov/1317407 DMJD34Q DI DMJD34Q DMJD34Q DN (-)-eseroline DMJD34Q MI TTKWM86 DMJD34Q MN Opioid receptor mu (MOP) DMJD34Q MT DTT DMJD34Q MA Inhibitor DMJD34Q RN Akuammine and dihydroakuammine, two indolomonoterpene alkaloids displaying affinity for opioid receptors. J Nat Prod. 1992 Mar;55(3):380-4. DMJD34Q RU https://pubmed.ncbi.nlm.nih.gov/1317407 DMBO9J3 DI DMBO9J3 DMBO9J3 DN (-)-huperzine B DMBO9J3 MI TT1RS9F DMBO9J3 MN Acetylcholinesterase (AChE) DMBO9J3 MT DTT DMBO9J3 MA Inhibitor DMBO9J3 RN Exploiting protein fluctuations at the active-site gorge of human cholinesterases: further optimization of the design strategy to develop extremely... J Med Chem. 2008 Jun 12;51(11):3154-70. DMBO9J3 RU https://pubmed.ncbi.nlm.nih.gov/18479118 DMJVNQB DI DMJVNQB DMJVNQB DN (-)-hydroxycitrate DMJVNQB MI TT0Z6Y2 DMJVNQB MN ATP-citrate synthase (ACLY) DMJVNQB MT DTT DMJVNQB MA Inhibitor DMJVNQB RN 2-hydroxy-N-arylbenzenesulfonamides as ATP-citrate lyase inhibitors. Bioorg Med Chem Lett. 2007 Jun 1;17(11):3208-11. DMJVNQB RU https://pubmed.ncbi.nlm.nih.gov/17383874 DMJS6IZ DI DMJS6IZ DMJS6IZ DN (-)-isoelaeocarpiline DMJS6IZ MI TT27RFC DMJS6IZ MN Opioid receptor delta (OPRD1) DMJS6IZ MT DTT DMJS6IZ MA Inhibitor DMJS6IZ RN Grandisines C-G, indolizidine alkaloids from the Australian rainforest tree Elaeocarpus grandis. J Nat Prod. 2006 Sep;69(9):1295-9. DMJS6IZ RU https://pubmed.ncbi.nlm.nih.gov/16989522 DMOY9J8 DI DMOY9J8 DMOY9J8 DN (-)-norfenfluramine DMOY9J8 MI TT0K1SC DMOY9J8 MN 5-HT 2B receptor (HTR2B) DMOY9J8 MT DTT DMOY9J8 MA Agonist DMOY9J8 RN Evidence for possible involvement of 5-HT(2B) receptors in the cardiac valvulopathy associated with fenfluramine and other serotonergic medications. Circulation. 2000 Dec 5;102(23):2836-41. DMOY9J8 RU https://pubmed.ncbi.nlm.nih.gov/11104741 DMVUEW5 DI DMVUEW5 DMVUEW5 DN (-)-Phenethylcymserine DMVUEW5 MI TTEB0GD DMVUEW5 MN Cholinesterase (BCHE) DMVUEW5 MT DTT DMVUEW5 MA Inhibitor DMVUEW5 RN Long-acting anticholinesterases for myasthenia gravis: synthesis and activities of quaternary phenylcarbamates of neostigmine, pyridostigmine and physostigmine. Bioorg Med Chem. 2010 Jul 1;18(13):4687-93. DMVUEW5 RU https://pubmed.ncbi.nlm.nih.gov/20627738 DM4INSG DI DM4INSG DM4INSG DN (-)-pinoresinol DM4INSG MI TTN9T81 DM4INSG MN Arachidonate 15-lipoxygenase (15-LOX) DM4INSG MT DTT DM4INSG MA Inhibitor DM4INSG RN Lipoxygenase inhibitory constituents of the fruits of noni (Morinda citrifolia) collected in Tahiti. J Nat Prod. 2007 May;70(5):859-62. DM4INSG RU https://pubmed.ncbi.nlm.nih.gov/17378609 DM4INSG DI DM4INSG DM4INSG DN (-)-pinoresinol DM4INSG MI TTSJ6Q4 DM4INSG MN LOX-5 messenger RNA (ALOX5 mRNA) DM4INSG MT DTT DM4INSG MA Inhibitor DM4INSG RN Lipoxygenase inhibitory constituents of the fruits of noni (Morinda citrifolia) collected in Tahiti. J Nat Prod. 2007 May;70(5):859-62. DM4INSG RU https://pubmed.ncbi.nlm.nih.gov/17378609 DMH6EVM DI DMH6EVM DMH6EVM DN (-)-Ro 363 DMH6EVM MI TTMXGCW DMH6EVM MN Adrenergic receptor beta-3 (ADRB3) DMH6EVM MT DTT DMH6EVM MA Agonist DMH6EVM RN Effects of (-)-RO363 at human atrial beta-adrenoceptor subtypes, the human cloned beta 3-adrenoceptor and rodent intestinal beta 3-adrenoceptors. Br J Pharmacol. 1997 Jan;120(2):165-76. DMH6EVM RU https://pubmed.ncbi.nlm.nih.gov/9117106 DMFE3YK DI DMFE3YK DMFE3YK DN (-)-SNAP-5399 DMFE3YK MI TTNGILX DMFE3YK MN Adrenergic receptor alpha-1A (ADRA1A) DMFE3YK MT DTT DMFE3YK MA Inhibitor DMFE3YK RN Pharmacophore identification of alpha(1A)-adrenoceptor antagonists. Bioorg Med Chem Lett. 2005 Feb 1;15(3):657-64. DMFE3YK RU https://pubmed.ncbi.nlm.nih.gov/15664832 DMKWIYP DI DMKWIYP DMKWIYP DN (-)-thujaplicatintrimethyl ether DMKWIYP MI TTXV4FI DMKWIYP MN Albendazole monooxygenase (CYP3A4) DMKWIYP MT DTT DMKWIYP MA Inhibitor DMKWIYP RN Potent CYP3A4 inhibitory constituents of Piper cubeba. J Nat Prod. 2005 Jan;68(1):64-8. DMKWIYP RU https://pubmed.ncbi.nlm.nih.gov/15679319 DMAT58Z DI DMAT58Z DMAT58Z DN (-)-Tolserine DMAT58Z MI TT1RS9F DMAT58Z MN Acetylcholinesterase (AChE) DMAT58Z MT DTT DMAT58Z MA Inhibitor DMAT58Z RN Long-acting anticholinesterases for myasthenia gravis: synthesis and activities of quaternary phenylcarbamates of neostigmine, pyridostigmine and physostigmine. Bioorg Med Chem. 2010 Jul 1;18(13):4687-93. DMAT58Z RU https://pubmed.ncbi.nlm.nih.gov/20627738 DMAT58Z DI DMAT58Z DMAT58Z DN (-)-Tolserine DMAT58Z MI TTEB0GD DMAT58Z MN Cholinesterase (BCHE) DMAT58Z MT DTT DMAT58Z MA Inhibitor DMAT58Z RN Long-acting anticholinesterases for myasthenia gravis: synthesis and activities of quaternary phenylcarbamates of neostigmine, pyridostigmine and physostigmine. Bioorg Med Chem. 2010 Jul 1;18(13):4687-93. DMAT58Z RU https://pubmed.ncbi.nlm.nih.gov/20627738 DMITWZ7 DI DMITWZ7 DMITWZ7 DN (-)-trans-H2-PAT DMITWZ7 MI TTTIBOJ DMITWZ7 MN Histamine H1 receptor (H1R) DMITWZ7 MT DTT DMITWZ7 MA Antagonist DMITWZ7 RN A novel phenylaminotetralin radioligand reveals a subpopulation of histamine H(1) receptors. J Pharmacol Exp Ther. 2002 Jul;302(1):328-36. DMITWZ7 RU https://pubmed.ncbi.nlm.nih.gov/12065734 DMRGVNJ DI DMRGVNJ DMRGVNJ DN (-)-uniflorine A DMRGVNJ MI TTLPC70 DMRGVNJ MN Lysosomal alpha-glucosidase (GAA) DMRGVNJ MT DTT DMRGVNJ MA Inhibitor DMRGVNJ RN Total synthesis of (-)-uniflorine A. J Nat Prod. 2009 Nov;72(11):2058-60. DMRGVNJ RU https://pubmed.ncbi.nlm.nih.gov/19835391 DMDHGIR DI DMDHGIR DMDHGIR DN (-)-yatein DMDHGIR MI TTXV4FI DMDHGIR MN Albendazole monooxygenase (CYP3A4) DMDHGIR MT DTT DMDHGIR MA Inhibitor DMDHGIR RN Potent CYP3A4 inhibitory constituents of Piper cubeba. J Nat Prod. 2005 Jan;68(1):64-8. DMDHGIR RU https://pubmed.ncbi.nlm.nih.gov/15679319 DMF62GN DI DMF62GN DMF62GN DN (+)-(1R,1'S)-berbamunine hydrochloride DMF62GN MI TTZFYLI DMF62GN MN Dopamine D1 receptor (D1R) DMF62GN MT DTT DMF62GN MA Inhibitor DMF62GN RN Displacement activity of bisbenzylisoquinoline alkaloids at striatal 3H-SCH 23390 and 3H-raclopride binding sites. J Nat Prod. 1992 Sep;55(9):1281-6. DMF62GN RU https://pubmed.ncbi.nlm.nih.gov/1431946 DMF62GN DI DMF62GN DMF62GN DN (+)-(1R,1'S)-berbamunine hydrochloride DMF62GN MI TTEX248 DMF62GN MN Dopamine D2 receptor (D2R) DMF62GN MT DTT DMF62GN MA Inhibitor DMF62GN RN Displacement activity of bisbenzylisoquinoline alkaloids at striatal 3H-SCH 23390 and 3H-raclopride binding sites. J Nat Prod. 1992 Sep;55(9):1281-6. DMF62GN RU https://pubmed.ncbi.nlm.nih.gov/1431946 DM521S4 DI DM521S4 DM521S4 DN (+)-(1R,1'S)-thaligrisine hydrochloride DM521S4 MI TTZFYLI DM521S4 MN Dopamine D1 receptor (D1R) DM521S4 MT DTT DM521S4 MA Inhibitor DM521S4 RN Displacement activity of bisbenzylisoquinoline alkaloids at striatal 3H-SCH 23390 and 3H-raclopride binding sites. J Nat Prod. 1992 Sep;55(9):1281-6. DM521S4 RU https://pubmed.ncbi.nlm.nih.gov/1431946 DM521S4 DI DM521S4 DM521S4 DN (+)-(1R,1'S)-thaligrisine hydrochloride DM521S4 MI TTEX248 DM521S4 MN Dopamine D2 receptor (D2R) DM521S4 MT DTT DM521S4 MA Inhibitor DM521S4 RN Displacement activity of bisbenzylisoquinoline alkaloids at striatal 3H-SCH 23390 and 3H-raclopride binding sites. J Nat Prod. 1992 Sep;55(9):1281-6. DM521S4 RU https://pubmed.ncbi.nlm.nih.gov/1431946 DMLDQWT DI DMLDQWT DMLDQWT DN (+)-(5S,8S,10S)-20-methoxy-9,15-ene-puupehenol DMLDQWT MI TT12ABZ DMLDQWT MN Arachidonate 12-lipoxygenase (12-LOX) DMLDQWT MT DTT DMLDQWT MA Inhibitor DMLDQWT RN Exploring sponge-derived terpenoids for their potency and selectivity against 12-human, 15-human, and 15-soybean lipoxygenases. J Nat Prod. 2003 Feb;66(2):230-5. DMLDQWT RU https://pubmed.ncbi.nlm.nih.gov/12608855 DMLDQWT DI DMLDQWT DMLDQWT DN (+)-(5S,8S,10S)-20-methoxy-9,15-ene-puupehenol DMLDQWT MI TTN9T81 DMLDQWT MN Arachidonate 15-lipoxygenase (15-LOX) DMLDQWT MT DTT DMLDQWT MA Inhibitor DMLDQWT RN Exploring sponge-derived terpenoids for their potency and selectivity against 12-human, 15-human, and 15-soybean lipoxygenases. J Nat Prod. 2003 Feb;66(2):230-5. DMLDQWT RU https://pubmed.ncbi.nlm.nih.gov/12608855 DMU7BJA DI DMU7BJA DMU7BJA DN (+)-(5S,8S,10S)-20-methoxypuupehenol DMU7BJA MI TT12ABZ DMU7BJA MN Arachidonate 12-lipoxygenase (12-LOX) DMU7BJA MT DTT DMU7BJA MA Inhibitor DMU7BJA RN Exploring sponge-derived terpenoids for their potency and selectivity against 12-human, 15-human, and 15-soybean lipoxygenases. J Nat Prod. 2003 Feb;66(2):230-5. DMU7BJA RU https://pubmed.ncbi.nlm.nih.gov/12608855 DMU7BJA DI DMU7BJA DMU7BJA DN (+)-(5S,8S,10S)-20-methoxypuupehenol DMU7BJA MI TTN9T81 DMU7BJA MN Arachidonate 15-lipoxygenase (15-LOX) DMU7BJA MT DTT DMU7BJA MA Inhibitor DMU7BJA RN Exploring sponge-derived terpenoids for their potency and selectivity against 12-human, 15-human, and 15-soybean lipoxygenases. J Nat Prod. 2003 Feb;66(2):230-5. DMU7BJA RU https://pubmed.ncbi.nlm.nih.gov/12608855 DMD4YPO DI DMD4YPO DMD4YPO DN (+)-(5S,8S,9R,10S)-20-methoxypuupehenone DMD4YPO MI TT12ABZ DMD4YPO MN Arachidonate 12-lipoxygenase (12-LOX) DMD4YPO MT DTT DMD4YPO MA Inhibitor DMD4YPO RN Exploring sponge-derived terpenoids for their potency and selectivity against 12-human, 15-human, and 15-soybean lipoxygenases. J Nat Prod. 2003 Feb;66(2):230-5. DMD4YPO RU https://pubmed.ncbi.nlm.nih.gov/12608855 DMD4YPO DI DMD4YPO DMD4YPO DN (+)-(5S,8S,9R,10S)-20-methoxypuupehenone DMD4YPO MI TTN9T81 DMD4YPO MN Arachidonate 15-lipoxygenase (15-LOX) DMD4YPO MT DTT DMD4YPO MA Inhibitor DMD4YPO RN Exploring sponge-derived terpenoids for their potency and selectivity against 12-human, 15-human, and 15-soybean lipoxygenases. J Nat Prod. 2003 Feb;66(2):230-5. DMD4YPO RU https://pubmed.ncbi.nlm.nih.gov/12608855 DMNUWVB DI DMNUWVB DMNUWVB DN (+)-3,3'-bisdemethyltanegool DMNUWVB MI TTN9T81 DMNUWVB MN Arachidonate 15-lipoxygenase (15-LOX) DMNUWVB MT DTT DMNUWVB MA Inhibitor DMNUWVB RN Lipoxygenase inhibitory constituents of the fruits of noni (Morinda citrifolia) collected in Tahiti. J Nat Prod. 2007 May;70(5):859-62. DMNUWVB RU https://pubmed.ncbi.nlm.nih.gov/17378609 DMNUWVB DI DMNUWVB DMNUWVB DN (+)-3,3'-bisdemethyltanegool DMNUWVB MI TTSJ6Q4 DMNUWVB MN LOX-5 messenger RNA (ALOX5 mRNA) DMNUWVB MT DTT DMNUWVB MA Inhibitor DMNUWVB RN Lipoxygenase inhibitory constituents of the fruits of noni (Morinda citrifolia) collected in Tahiti. J Nat Prod. 2007 May;70(5):859-62. DMNUWVB RU https://pubmed.ncbi.nlm.nih.gov/17378609 DM2CHX8 DI DM2CHX8 DM2CHX8 DN (+)-5-(5-bromothiophen-3-yl)-5-methyl-4-oxo-4,5-dihydro-furan-2-carboxylic acid DM2CHX8 MI TTWNV8U DM2CHX8 MN Nicotinic acid receptor (HCAR2) DM2CHX8 MT DTT DM2CHX8 MA Agonist DM2CHX8 RN (D)-beta-Hydroxybutyrate inhibits adipocyte lipolysis via the nicotinic acid receptor PUMA-G. J Biol Chem. 2005 Jul 22;280(29):26649-52. DM2CHX8 RU https://pubmed.ncbi.nlm.nih.gov/15929991 DMF8C50 DI DMF8C50 DMF8C50 DN (+)-5-deoxyadeenophorine DMF8C50 MI TTIS03D DMF8C50 MN Alpha-galactosidase A (GLA) DMF8C50 MT DTT DMF8C50 MA Inhibitor DMF8C50 RN Flexible synthesis and biological evaluation of novel 5-deoxyadenophorine analogues. Bioorg Med Chem Lett. 2006 Jun 15;16(12):3262-7. DMF8C50 RU https://pubmed.ncbi.nlm.nih.gov/16603357 DMXWCVY DI DMXWCVY DMXWCVY DN (+)-ADTN DMXWCVY MI TTZFYLI DMXWCVY MN Dopamine D1 receptor (D1R) DMXWCVY MT DTT DMXWCVY MA Agonist DMXWCVY RN Cloning of the gene for a human dopamine D5 receptor with higher affinity for dopamine than D1. Nature. 1991 Apr 18;350(6319):614-9. DMXWCVY RU https://pubmed.ncbi.nlm.nih.gov/1826762 DMXWCVY DI DMXWCVY DMXWCVY DN (+)-ADTN DMXWCVY MI TTS2PH3 DMXWCVY MN Dopamine D5 receptor (D5R) DMXWCVY MT DTT DMXWCVY MA Agonist DMXWCVY RN Cloning of the gene for a human dopamine D5 receptor with higher affinity for dopamine than D1. Nature. 1991 Apr 18;350(6319):614-9. DMXWCVY RU https://pubmed.ncbi.nlm.nih.gov/1826762 DMEDMC0 DI DMEDMC0 DMEDMC0 DN (+)-AJ76 DMEDMC0 MI TT4C8EA DMEDMC0 MN Dopamine D3 receptor (D3R) DMEDMC0 MT DTT DMEDMC0 MA Antagonist DMEDMC0 RN Molecular cloning and characterization of a novel dopamine receptor (D3) as a target for neuroleptics. Nature. 1990 Sep 13;347(6289):146-51. DMEDMC0 RU https://pubmed.ncbi.nlm.nih.gov/1975644 DMX6UYN DI DMX6UYN DMX6UYN DN (+)-BUTACLAMOL DMX6UYN MI TTJFY5U DMX6UYN MN Adenosine A3 receptor (ADORA3) DMX6UYN MT DTT DMX6UYN MA Inhibitor DMX6UYN RN 2-n-Butyl-9-methyl-8-[1,2,3]triazol-2-yl-9H-purin-6-ylamine and analogues as A2A adenosine receptor antagonists. Design, synthesis, and pharmacolog... J Med Chem. 2005 Nov 3;48(22):6887-96. DMX6UYN RU https://pubmed.ncbi.nlm.nih.gov/16250647 DMX6UYN DI DMX6UYN DMX6UYN DN (+)-BUTACLAMOL DMX6UYN MI TTZFYLI DMX6UYN MN Dopamine D1 receptor (D1R) DMX6UYN MT DTT DMX6UYN MA Inhibitor DMX6UYN RN 7-Methyl-6,7,8,9,14,15-hexahydro-5H-benz[d]indolo[2,3-g]azecine: a new heterocyclic system and a new lead compound for dopamine receptor antagonists. J Med Chem. 2000 May 18;43(10):2079-81. DMX6UYN RU https://pubmed.ncbi.nlm.nih.gov/10821720 DMX6UYN DI DMX6UYN DMX6UYN DN (+)-BUTACLAMOL DMX6UYN MI TTEX248 DMX6UYN MN Dopamine D2 receptor (D2R) DMX6UYN MT DTT DMX6UYN MA Inhibitor DMX6UYN RN Synthesis and structure-activity relationships of 1-aralkyl-4-benzylpiperidine and 1-aralkyl-4-benzylpiperazine derivatives as potent sigma ligands. J Med Chem. 2005 Jan 13;48(1):266-73. DMX6UYN RU https://pubmed.ncbi.nlm.nih.gov/15634021 DMX6UYN DI DMX6UYN DMX6UYN DN (+)-BUTACLAMOL DMX6UYN MI TT4C8EA DMX6UYN MN Dopamine D3 receptor (D3R) DMX6UYN MT DTT DMX6UYN MA Inhibitor DMX6UYN RN cis-4-(Piperazin-1-yl)-5,6,7a,8,9,10,11,11a-octahydrobenzofuro[2,3-h]quinazolin-2-amine (A-987306), a new histamine H4R antagonist that blocks pain... J Med Chem. 2008 Nov 27;51(22):7094-8. DMX6UYN RU https://pubmed.ncbi.nlm.nih.gov/18983139 DMDFR59 DI DMDFR59 DMDFR59 DN (+)-cis-H2-PAT DMDFR59 MI TTTIBOJ DMDFR59 MN Histamine H1 receptor (H1R) DMDFR59 MT DTT DMDFR59 MA Antagonist DMDFR59 RN A novel phenylaminotetralin radioligand reveals a subpopulation of histamine H(1) receptors. J Pharmacol Exp Ther. 2002 Jul;302(1):328-36. DMDFR59 RU https://pubmed.ncbi.nlm.nih.gov/12065734 DMKWEAJ DI DMKWEAJ DMKWEAJ DN (+)-HA966 DMKWEAJ MI TTLD29N DMKWEAJ MN Glutamate receptor ionotropic NMDA 1 (NMDAR1) DMKWEAJ MT DTT DMKWEAJ MA Agonist DMKWEAJ RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 455). DMKWEAJ RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=455 DMKWEAJ DI DMKWEAJ DMKWEAJ DN (+)-HA966 DMKWEAJ MI TTKJEMQ DMKWEAJ MN Glutamate receptor ionotropic NMDA 2A (NMDAR2A) DMKWEAJ MT DTT DMKWEAJ MA Agonist DMKWEAJ RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 456). DMKWEAJ RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=456 DMKWEAJ DI DMKWEAJ DMKWEAJ DN (+)-HA966 DMKWEAJ MI TTN9D8E DMKWEAJ MN Glutamate receptor ionotropic NMDA 2B (NMDAR2B) DMKWEAJ MT DTT DMKWEAJ MA Agonist DMKWEAJ RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 457). DMKWEAJ RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=457 DMG5QJB DI DMG5QJB DMG5QJB DN (+)-MCPG DMG5QJB MI TTVBPDM DMG5QJB MN Metabotropic glutamate receptor 1 (mGluR1) DMG5QJB MT DTT DMG5QJB MA Antagonist DMG5QJB RN [3H]R214127: a novel high-affinity radioligand for the mGlu1 receptor reveals a common binding site shared by multiple allosteric antagonists. Mol Pharmacol. 2003 May;63(5):1082-93. DMG5QJB RU https://pubmed.ncbi.nlm.nih.gov/12695537 DMG5QJB DI DMG5QJB DMG5QJB DN (+)-MCPG DMG5QJB MI TTXJ47W DMG5QJB MN Metabotropic glutamate receptor 2 (mGluR2) DMG5QJB MT DTT DMG5QJB MA Antagonist DMG5QJB RN Characterization of [3H]-(2S,2'R,3'R)-2-(2',3'-dicarboxy-cyclopropyl)glycine ([3H]-DCG IV) binding to metabotropic mGlu2 receptor-transfected cell membranes. Br J Pharmacol. 1998 Feb;123(3):497-504. DMG5QJB RU https://pubmed.ncbi.nlm.nih.gov/9504391 DMG5QJB DI DMG5QJB DMG5QJB DN (+)-MCPG DMG5QJB MI TT8A9EF DMG5QJB MN Metabotropic glutamate receptor 3 (mGluR3) DMG5QJB MT DTT DMG5QJB MA Antagonist DMG5QJB RN [3H]-LY341495 as a novel antagonist radioligand for group II metabotropic glutamate (mGlu) receptors: characterization of binding to membranes of mGlu receptor subtype expressing cells. Neuropharmacology. 1999 Oct;38(10):1519-29. DMG5QJB RU https://pubmed.ncbi.nlm.nih.gov/10530814 DMG5QJB DI DMG5QJB DMG5QJB DN (+)-MCPG DMG5QJB MI TTHS256 DMG5QJB MN Metabotropic glutamate receptor 5 (mGluR5) DMG5QJB MT DTT DMG5QJB MA Antagonist DMG5QJB RN Characterization of [(3)H]Quisqualate binding to recombinant rat metabotropic glutamate 1a and 5a receptors and to rat and human brain sections. J Neurochem. 2000 Dec;75(6):2590-601. DMG5QJB RU https://pubmed.ncbi.nlm.nih.gov/11080213 DMG5QJB DI DMG5QJB DMG5QJB DN (+)-MCPG DMG5QJB MI TT0I76D DMG5QJB MN Metabotropic glutamate receptor 7 (mGluR7) DMG5QJB MT DTT DMG5QJB MA Antagonist DMG5QJB RN Binding of [3H](2S,1'S,2'S)-2-(9-xanthylmethyl)-2-(2'-carboxycyclopropyl) glycine ([3H]LY341495) to cell membranes expressing recombinant human group III metabotropic glutamate receptor subtypes. Naunyn Schmiedebergs Arch Pharmacol. 2000 Dec;362(6):546-54. DMG5QJB RU https://pubmed.ncbi.nlm.nih.gov/11138847 DM7FZHI DI DM7FZHI DM7FZHI DN (+)-Myristinin A DM7FZHI MI TTIU7X1 DM7FZHI MN Herpes simplex virus DNA polymerase UL30 (HSV UL30) DM7FZHI MT DTT DM7FZHI MA Inhibitor DM7FZHI RN (+)-Myristinins A and D from Knema elegans, which inhibit DNA polymerase beta and cleave DNA. J Nat Prod. 2005 Nov;68(11):1625-8. DM7FZHI RU https://pubmed.ncbi.nlm.nih.gov/16309311 DMEK07T DI DMEK07T DMEK07T DN (+)-Myristinin D DMEK07T MI TTIU7X1 DMEK07T MN Herpes simplex virus DNA polymerase UL30 (HSV UL30) DMEK07T MT DTT DMEK07T MA Inhibitor DMEK07T RN (+)-Myristinins A and D from Knema elegans, which inhibit DNA polymerase beta and cleave DNA. J Nat Prod. 2005 Nov;68(11):1625-8. DMEK07T RU https://pubmed.ncbi.nlm.nih.gov/16309311 DMOZJA5 DI DMOZJA5 DMOZJA5 DN (+)-norfenfluramine DMOZJA5 MI TT0K1SC DMOZJA5 MN 5-HT 2B receptor (HTR2B) DMOZJA5 MT DTT DMOZJA5 MA Agonist DMOZJA5 RN Evidence for possible involvement of 5-HT(2B) receptors in the cardiac valvulopathy associated with fenfluramine and other serotonergic medications. Circulation. 2000 Dec 5;102(23):2836-41. DMOZJA5 RU https://pubmed.ncbi.nlm.nih.gov/11104741 DMX7ECD DI DMX7ECD DMX7ECD DN (+)-S-14297 DMX7ECD MI TTEX248 DMX7ECD MN Dopamine D2 receptor (D2R) DMX7ECD MT DTT DMX7ECD MA Antagonist DMX7ECD RN Functional correlates of dopamine D3 receptor activation in the rat in vivo and their modulation by the selective antagonist, (+)-S 14297: 1. Activation of postsynaptic D3 receptors mediates hypothermia, whereas blockade of D2 receptors elicits prolactin secretion and catalepsy. J Pharmacol Exp Ther. 1995 Nov;275(2):885-98. DMX7ECD RU https://pubmed.ncbi.nlm.nih.gov/7473180 DMX7ECD DI DMX7ECD DMX7ECD DN (+)-S-14297 DMX7ECD MI TT4C8EA DMX7ECD MN Dopamine D3 receptor (D3R) DMX7ECD MT DTT DMX7ECD MA Antagonist DMX7ECD RN S 14297, a novel selective ligand at cloned human dopamine D3 receptors, blocks 7-OH-DPAT-induced hypothermia in rats. Eur J Pharmacol. 1994 Aug 1;260(2-3):R3-5. DMX7ECD RU https://pubmed.ncbi.nlm.nih.gov/7988633 DM1QPA4 DI DM1QPA4 DM1QPA4 DN (+)-SK&F10047 DM1QPA4 MI TT5TPI6 DM1QPA4 MN Opioid receptor sigma 1 (OPRS1) DM1QPA4 MT DTT DM1QPA4 MA Agonist DM1QPA4 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2552). DM1QPA4 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2552 DMAN63P DI DMAN63P DMAN63P DN (+)-trans-H2-PAT DMAN63P MI TTTIBOJ DMAN63P MN Histamine H1 receptor (H1R) DMAN63P MT DTT DMAN63P MA Antagonist DMAN63P RN A novel phenylaminotetralin radioligand reveals a subpopulation of histamine H(1) receptors. J Pharmacol Exp Ther. 2002 Jul;302(1):328-36. DMAN63P RU https://pubmed.ncbi.nlm.nih.gov/12065734 DMDXKQ6 DI DMDXKQ6 DMDXKQ6 DN (+/-)-2-(4'-Benzyloxyphenyl)thiomorpholin-5-one DMDXKQ6 MI TTGP7BY DMDXKQ6 MN Monoamine oxidase type B (MAO-B) DMDXKQ6 MT DTT DMDXKQ6 MA Inhibitor DMDXKQ6 RN 2-Arylthiomorpholine derivatives as potent and selective monoamine oxidase B inhibitors. Bioorg Med Chem. 2010 Feb 15;18(4):1388-95. DMDXKQ6 RU https://pubmed.ncbi.nlm.nih.gov/20123154 DMCB74T DI DMCB74T DMCB74T DN (+/-)-2-(4'-Benzyloxyphenyl)thiomorpholine DMCB74T MI TT3WG5C DMCB74T MN Monoamine oxidase type A (MAO-A) DMCB74T MT DTT DMCB74T MA Inhibitor DMCB74T RN 2-Arylthiomorpholine derivatives as potent and selective monoamine oxidase B inhibitors. Bioorg Med Chem. 2010 Feb 15;18(4):1388-95. DMCB74T RU https://pubmed.ncbi.nlm.nih.gov/20123154 DMCB74T DI DMCB74T DMCB74T DN (+/-)-2-(4'-Benzyloxyphenyl)thiomorpholine DMCB74T MI TTGP7BY DMCB74T MN Monoamine oxidase type B (MAO-B) DMCB74T MT DTT DMCB74T MA Inhibitor DMCB74T RN 2-Arylthiomorpholine derivatives as potent and selective monoamine oxidase B inhibitors. Bioorg Med Chem. 2010 Feb 15;18(4):1388-95. DMCB74T RU https://pubmed.ncbi.nlm.nih.gov/20123154 DM1WCJV DI DM1WCJV DM1WCJV DN (+/-)-2-(4'-Butoxyphenyl)thiomorpholin-5-one DM1WCJV MI TT3WG5C DM1WCJV MN Monoamine oxidase type A (MAO-A) DM1WCJV MT DTT DM1WCJV MA Inhibitor DM1WCJV RN 2-Arylthiomorpholine derivatives as potent and selective monoamine oxidase B inhibitors. Bioorg Med Chem. 2010 Feb 15;18(4):1388-95. DM1WCJV RU https://pubmed.ncbi.nlm.nih.gov/20123154 DM1WCJV DI DM1WCJV DM1WCJV DN (+/-)-2-(4'-Butoxyphenyl)thiomorpholin-5-one DM1WCJV MI TTGP7BY DM1WCJV MN Monoamine oxidase type B (MAO-B) DM1WCJV MT DTT DM1WCJV MA Inhibitor DM1WCJV RN 2-Arylthiomorpholine derivatives as potent and selective monoamine oxidase B inhibitors. Bioorg Med Chem. 2010 Feb 15;18(4):1388-95. DM1WCJV RU https://pubmed.ncbi.nlm.nih.gov/20123154 DMG3MF2 DI DMG3MF2 DMG3MF2 DN (+/-)-2-(4'-Butoxyphenyl)thiomorpholine DMG3MF2 MI TT3WG5C DMG3MF2 MN Monoamine oxidase type A (MAO-A) DMG3MF2 MT DTT DMG3MF2 MA Inhibitor DMG3MF2 RN 2-Arylthiomorpholine derivatives as potent and selective monoamine oxidase B inhibitors. Bioorg Med Chem. 2010 Feb 15;18(4):1388-95. DMG3MF2 RU https://pubmed.ncbi.nlm.nih.gov/20123154 DMG3MF2 DI DMG3MF2 DMG3MF2 DN (+/-)-2-(4'-Butoxyphenyl)thiomorpholine DMG3MF2 MI TTGP7BY DMG3MF2 MN Monoamine oxidase type B (MAO-B) DMG3MF2 MT DTT DMG3MF2 MA Inhibitor DMG3MF2 RN 2-Arylthiomorpholine derivatives as potent and selective monoamine oxidase B inhibitors. Bioorg Med Chem. 2010 Feb 15;18(4):1388-95. DMG3MF2 RU https://pubmed.ncbi.nlm.nih.gov/20123154 DM1YBJ2 DI DM1YBJ2 DM1YBJ2 DN (+/-)-2-(4'-Ethoxyphenyl)thiomorpholin-5-one DM1YBJ2 MI TT3WG5C DM1YBJ2 MN Monoamine oxidase type A (MAO-A) DM1YBJ2 MT DTT DM1YBJ2 MA Inhibitor DM1YBJ2 RN 2-Arylthiomorpholine derivatives as potent and selective monoamine oxidase B inhibitors. Bioorg Med Chem. 2010 Feb 15;18(4):1388-95. DM1YBJ2 RU https://pubmed.ncbi.nlm.nih.gov/20123154 DM1YBJ2 DI DM1YBJ2 DM1YBJ2 DN (+/-)-2-(4'-Ethoxyphenyl)thiomorpholin-5-one DM1YBJ2 MI TTGP7BY DM1YBJ2 MN Monoamine oxidase type B (MAO-B) DM1YBJ2 MT DTT DM1YBJ2 MA Inhibitor DM1YBJ2 RN 2-Arylthiomorpholine derivatives as potent and selective monoamine oxidase B inhibitors. Bioorg Med Chem. 2010 Feb 15;18(4):1388-95. DM1YBJ2 RU https://pubmed.ncbi.nlm.nih.gov/20123154 DMKPX7W DI DMKPX7W DMKPX7W DN (+/-)-2-(4'-Ethoxyphenyl)thiomorpholine DMKPX7W MI TT3WG5C DMKPX7W MN Monoamine oxidase type A (MAO-A) DMKPX7W MT DTT DMKPX7W MA Inhibitor DMKPX7W RN 2-Arylthiomorpholine derivatives as potent and selective monoamine oxidase B inhibitors. Bioorg Med Chem. 2010 Feb 15;18(4):1388-95. DMKPX7W RU https://pubmed.ncbi.nlm.nih.gov/20123154 DMKPX7W DI DMKPX7W DMKPX7W DN (+/-)-2-(4'-Ethoxyphenyl)thiomorpholine DMKPX7W MI TTGP7BY DMKPX7W MN Monoamine oxidase type B (MAO-B) DMKPX7W MT DTT DMKPX7W MA Inhibitor DMKPX7W RN 2-Arylthiomorpholine derivatives as potent and selective monoamine oxidase B inhibitors. Bioorg Med Chem. 2010 Feb 15;18(4):1388-95. DMKPX7W RU https://pubmed.ncbi.nlm.nih.gov/20123154 DMGY5WB DI DMGY5WB DMGY5WB DN (+/-)-2-(4-fluorophenyl)-7-methoxychroman-4-one DMGY5WB MI TTGP7BY DMGY5WB MN Monoamine oxidase type B (MAO-B) DMGY5WB MT DTT DMGY5WB MA Inhibitor DMGY5WB RN A new series of flavones, thioflavones, and flavanones as selective monoamine oxidase-B inhibitors. Bioorg Med Chem. 2010 Feb;18(3):1273-9. DMGY5WB RU https://pubmed.ncbi.nlm.nih.gov/20045650 DMHL7BC DI DMHL7BC DMHL7BC DN (+/-)-2-(4-fluorophenyl)-7-methylchroman-4-one DMHL7BC MI TTGP7BY DMHL7BC MN Monoamine oxidase type B (MAO-B) DMHL7BC MT DTT DMHL7BC MA Inhibitor DMHL7BC RN A new series of flavones, thioflavones, and flavanones as selective monoamine oxidase-B inhibitors. Bioorg Med Chem. 2010 Feb;18(3):1273-9. DMHL7BC RU https://pubmed.ncbi.nlm.nih.gov/20045650 DMXK4HR DI DMXK4HR DMXK4HR DN (+/-)-2-(4-fluorophenyl)chroman-4-one DMXK4HR MI TTGP7BY DMXK4HR MN Monoamine oxidase type B (MAO-B) DMXK4HR MT DTT DMXK4HR MA Inhibitor DMXK4HR RN A new series of flavones, thioflavones, and flavanones as selective monoamine oxidase-B inhibitors. Bioorg Med Chem. 2010 Feb;18(3):1273-9. DMXK4HR RU https://pubmed.ncbi.nlm.nih.gov/20045650 DMTUFOE DI DMTUFOE DMTUFOE DN (+/-)-2-(4-methoxyphenyl)-7-methylchroman-4-one DMTUFOE MI TTGP7BY DMTUFOE MN Monoamine oxidase type B (MAO-B) DMTUFOE MT DTT DMTUFOE MA Inhibitor DMTUFOE RN A new series of flavones, thioflavones, and flavanones as selective monoamine oxidase-B inhibitors. Bioorg Med Chem. 2010 Feb;18(3):1273-9. DMTUFOE RU https://pubmed.ncbi.nlm.nih.gov/20045650 DM7BY4T DI DM7BY4T DM7BY4T DN (+/-)-2-(4'-Methoxyphenyl)thiomorpholin-5-one DM7BY4T MI TT3WG5C DM7BY4T MN Monoamine oxidase type A (MAO-A) DM7BY4T MT DTT DM7BY4T MA Inhibitor DM7BY4T RN 2-Arylthiomorpholine derivatives as potent and selective monoamine oxidase B inhibitors. Bioorg Med Chem. 2010 Feb 15;18(4):1388-95. DM7BY4T RU https://pubmed.ncbi.nlm.nih.gov/20123154 DM7BY4T DI DM7BY4T DM7BY4T DN (+/-)-2-(4'-Methoxyphenyl)thiomorpholin-5-one DM7BY4T MI TTGP7BY DM7BY4T MN Monoamine oxidase type B (MAO-B) DM7BY4T MT DTT DM7BY4T MA Inhibitor DM7BY4T RN 2-Arylthiomorpholine derivatives as potent and selective monoamine oxidase B inhibitors. Bioorg Med Chem. 2010 Feb 15;18(4):1388-95. DM7BY4T RU https://pubmed.ncbi.nlm.nih.gov/20123154 DMKFSQ8 DI DMKFSQ8 DMKFSQ8 DN (+/-)-2-(4'-Methoxyphenyl)thiomorpholine DMKFSQ8 MI TT3WG5C DMKFSQ8 MN Monoamine oxidase type A (MAO-A) DMKFSQ8 MT DTT DMKFSQ8 MA Inhibitor DMKFSQ8 RN 2-Arylthiomorpholine derivatives as potent and selective monoamine oxidase B inhibitors. Bioorg Med Chem. 2010 Feb 15;18(4):1388-95. DMKFSQ8 RU https://pubmed.ncbi.nlm.nih.gov/20123154 DMKFSQ8 DI DMKFSQ8 DMKFSQ8 DN (+/-)-2-(4'-Methoxyphenyl)thiomorpholine DMKFSQ8 MI TTGP7BY DMKFSQ8 MN Monoamine oxidase type B (MAO-B) DMKFSQ8 MT DTT DMKFSQ8 MA Inhibitor DMKFSQ8 RN 2-Arylthiomorpholine derivatives as potent and selective monoamine oxidase B inhibitors. Bioorg Med Chem. 2010 Feb 15;18(4):1388-95. DMKFSQ8 RU https://pubmed.ncbi.nlm.nih.gov/20123154 DMY1W20 DI DMY1W20 DMY1W20 DN (+/-)-2-(4'-Propoxyphenyl)thiomorpholin-5-one DMY1W20 MI TT3WG5C DMY1W20 MN Monoamine oxidase type A (MAO-A) DMY1W20 MT DTT DMY1W20 MA Inhibitor DMY1W20 RN 2-Arylthiomorpholine derivatives as potent and selective monoamine oxidase B inhibitors. Bioorg Med Chem. 2010 Feb 15;18(4):1388-95. DMY1W20 RU https://pubmed.ncbi.nlm.nih.gov/20123154 DMY1W20 DI DMY1W20 DMY1W20 DN (+/-)-2-(4'-Propoxyphenyl)thiomorpholin-5-one DMY1W20 MI TTGP7BY DMY1W20 MN Monoamine oxidase type B (MAO-B) DMY1W20 MT DTT DMY1W20 MA Inhibitor DMY1W20 RN 2-Arylthiomorpholine derivatives as potent and selective monoamine oxidase B inhibitors. Bioorg Med Chem. 2010 Feb 15;18(4):1388-95. DMY1W20 RU https://pubmed.ncbi.nlm.nih.gov/20123154 DMUPYN1 DI DMUPYN1 DMUPYN1 DN (+/-)-2-(4'-Propoxyphenyl)thiomorpholine DMUPYN1 MI TT3WG5C DMUPYN1 MN Monoamine oxidase type A (MAO-A) DMUPYN1 MT DTT DMUPYN1 MA Inhibitor DMUPYN1 RN 2-Arylthiomorpholine derivatives as potent and selective monoamine oxidase B inhibitors. Bioorg Med Chem. 2010 Feb 15;18(4):1388-95. DMUPYN1 RU https://pubmed.ncbi.nlm.nih.gov/20123154 DMUPYN1 DI DMUPYN1 DMUPYN1 DN (+/-)-2-(4'-Propoxyphenyl)thiomorpholine DMUPYN1 MI TTGP7BY DMUPYN1 MN Monoamine oxidase type B (MAO-B) DMUPYN1 MT DTT DMUPYN1 MA Inhibitor DMUPYN1 RN 2-Arylthiomorpholine derivatives as potent and selective monoamine oxidase B inhibitors. Bioorg Med Chem. 2010 Feb 15;18(4):1388-95. DMUPYN1 RU https://pubmed.ncbi.nlm.nih.gov/20123154 DMX768L DI DMX768L DMX768L DN (+/-)-2-Amino-1,2,3,4-tetrahydro-2-naphthoic acid DMX768L MI TTPH2JB DMX768L MN Large neutral amino acids transporter 1 (SLC7A5) DMX768L MT DTT DMX768L MA Inhibitor DMX768L RN Regiospecific and conformationally restrained analogs of melphalan and DL-2-NAM-7 and their affinities for the large neutral amino acid transporter... Bioorg Med Chem Lett. 2010 Jun 15;20(12):3688-91. DMX768L RU https://pubmed.ncbi.nlm.nih.gov/20466543 DML5URN DI DML5URN DML5URN DN (+/-)-2-Aminoindane-2-carboxylic acid DML5URN MI TTPH2JB DML5URN MN Large neutral amino acids transporter 1 (SLC7A5) DML5URN MT DTT DML5URN MA Inhibitor DML5URN RN Regiospecific and conformationally restrained analogs of melphalan and DL-2-NAM-7 and their affinities for the large neutral amino acid transporter... Bioorg Med Chem Lett. 2010 Jun 15;20(12):3688-91. DML5URN RU https://pubmed.ncbi.nlm.nih.gov/20466543 DMJ6MPO DI DMJ6MPO DMJ6MPO DN (+/-)-2-Methyl-1-(1-phenylethyl)-1H-imidazole DMJ6MPO MI TTZUFI5 DMJ6MPO MN Nitric-oxide synthase brain (NOS1) DMJ6MPO MT DTT DMJ6MPO MA Inhibitor DMJ6MPO RN N-Substituted acetamidines and 2-methylimidazole derivatives as selective inhibitors of neuronal nitric oxide synthase. Bioorg Med Chem Lett. 2010 Nov 15;20(22):6495-9. DMJ6MPO RU https://pubmed.ncbi.nlm.nih.gov/20933416 DMSHDNO DI DMSHDNO DMSHDNO DN (+/-)-2-Phenylthiomorpholin-5-one DMSHDNO MI TT3WG5C DMSHDNO MN Monoamine oxidase type A (MAO-A) DMSHDNO MT DTT DMSHDNO MA Inhibitor DMSHDNO RN 2-Arylthiomorpholine derivatives as potent and selective monoamine oxidase B inhibitors. Bioorg Med Chem. 2010 Feb 15;18(4):1388-95. DMSHDNO RU https://pubmed.ncbi.nlm.nih.gov/20123154 DMSHDNO DI DMSHDNO DMSHDNO DN (+/-)-2-Phenylthiomorpholin-5-one DMSHDNO MI TTGP7BY DMSHDNO MN Monoamine oxidase type B (MAO-B) DMSHDNO MT DTT DMSHDNO MA Inhibitor DMSHDNO RN 2-Arylthiomorpholine derivatives as potent and selective monoamine oxidase B inhibitors. Bioorg Med Chem. 2010 Feb 15;18(4):1388-95. DMSHDNO RU https://pubmed.ncbi.nlm.nih.gov/20123154 DMNR3YL DI DMNR3YL DMNR3YL DN (+/-)-2-Phenylthiomorpholine DMNR3YL MI TT3WG5C DMNR3YL MN Monoamine oxidase type A (MAO-A) DMNR3YL MT DTT DMNR3YL MA Inhibitor DMNR3YL RN 2-Arylthiomorpholine derivatives as potent and selective monoamine oxidase B inhibitors. Bioorg Med Chem. 2010 Feb 15;18(4):1388-95. DMNR3YL RU https://pubmed.ncbi.nlm.nih.gov/20123154 DMNR3YL DI DMNR3YL DMNR3YL DN (+/-)-2-Phenylthiomorpholine DMNR3YL MI TTGP7BY DMNR3YL MN Monoamine oxidase type B (MAO-B) DMNR3YL MT DTT DMNR3YL MA Inhibitor DMNR3YL RN 2-Arylthiomorpholine derivatives as potent and selective monoamine oxidase B inhibitors. Bioorg Med Chem. 2010 Feb 15;18(4):1388-95. DMNR3YL RU https://pubmed.ncbi.nlm.nih.gov/20123154 DMYJGZ4 DI DMYJGZ4 DMYJGZ4 DN (+/-)-2-p-tolylchroman-4-one DMYJGZ4 MI TTGP7BY DMYJGZ4 MN Monoamine oxidase type B (MAO-B) DMYJGZ4 MT DTT DMYJGZ4 MA Inhibitor DMYJGZ4 RN A new series of flavones, thioflavones, and flavanones as selective monoamine oxidase-B inhibitors. Bioorg Med Chem. 2010 Feb;18(3):1273-9. DMYJGZ4 RU https://pubmed.ncbi.nlm.nih.gov/20045650 DML68KX DI DML68KX DML68KX DN (+/-)-3-((naphthalen-2-yloxy)methyl)pyrrolidine DML68KX MI TTVBI8W DML68KX MN Dopamine transporter (DAT) DML68KX MT DTT DML68KX MA Inhibitor DML68KX RN Design and optimization of selective serotonin re-uptake inhibitors with high synthetic accessibility. Part 1. Bioorg Med Chem Lett. 2009 Apr 15;19(8):2329-32. DML68KX RU https://pubmed.ncbi.nlm.nih.gov/19282174 DML68KX DI DML68KX DML68KX DN (+/-)-3-((naphthalen-2-yloxy)methyl)pyrrolidine DML68KX MI TTAWNKZ DML68KX MN Norepinephrine transporter (NET) DML68KX MT DTT DML68KX MA Inhibitor DML68KX RN Design and optimization of selective serotonin re-uptake inhibitors with high synthetic accessibility. Part 1. Bioorg Med Chem Lett. 2009 Apr 15;19(8):2329-32. DML68KX RU https://pubmed.ncbi.nlm.nih.gov/19282174 DML68KX DI DML68KX DML68KX DN (+/-)-3-((naphthalen-2-yloxy)methyl)pyrrolidine DML68KX MI TT3ROYC DML68KX MN Serotonin transporter (SERT) DML68KX MT DTT DML68KX MA Inhibitor DML68KX RN Design and optimization of selective serotonin re-uptake inhibitors with high synthetic accessibility. Part 1. Bioorg Med Chem Lett. 2009 Apr 15;19(8):2329-32. DML68KX RU https://pubmed.ncbi.nlm.nih.gov/19282174 DM9AJSU DI DM9AJSU DM9AJSU DN (+/-)-3-(but-3-enyl)-1-pent-4-enoylazetidin-2-one DM9AJSU MI TTDP1UC DM9AJSU MN Fatty acid amide hydrolase (FAAH) DM9AJSU MT DTT DM9AJSU MA Inhibitor DM9AJSU RN 3-Alkenyl-2-azetidinones as fatty acid amide hydrolase inhibitors. Bioorg Med Chem Lett. 2008 Jul 15;18(14):4163-7. DM9AJSU RU https://pubmed.ncbi.nlm.nih.gov/18547805 DMWIABE DI DMWIABE DMWIABE DN (+/-)-3-(pent-4-enyl)azetidin-2-one DMWIABE MI TTDP1UC DMWIABE MN Fatty acid amide hydrolase (FAAH) DMWIABE MT DTT DMWIABE MA Inhibitor DMWIABE RN 3-Alkenyl-2-azetidinones as fatty acid amide hydrolase inhibitors. Bioorg Med Chem Lett. 2008 Jul 15;18(14):4163-7. DMWIABE RU https://pubmed.ncbi.nlm.nih.gov/18547805 DMS5AWP DI DMS5AWP DMS5AWP DN (+/-)-3-allyl-1-pent-4-enoylazetidin-2-one DMS5AWP MI TTDP1UC DMS5AWP MN Fatty acid amide hydrolase (FAAH) DMS5AWP MT DTT DMS5AWP MA Inhibitor DMS5AWP RN 3-Alkenyl-2-azetidinones as fatty acid amide hydrolase inhibitors. Bioorg Med Chem Lett. 2008 Jul 15;18(14):4163-7. DMS5AWP RU https://pubmed.ncbi.nlm.nih.gov/18547805 DMK42RU DI DMK42RU DMK42RU DN (+/-)-3-allylazetidin-2-one DMK42RU MI TTDP1UC DMK42RU MN Fatty acid amide hydrolase (FAAH) DMK42RU MT DTT DMK42RU MA Inhibitor DMK42RU RN 3-Alkenyl-2-azetidinones as fatty acid amide hydrolase inhibitors. Bioorg Med Chem Lett. 2008 Jul 15;18(14):4163-7. DMK42RU RU https://pubmed.ncbi.nlm.nih.gov/18547805 DMSN7GJ DI DMSN7GJ DMSN7GJ DN (+/-)5-(biphenyl-4-yl)-3-hydroxypentanoic acid DMSN7GJ MI TTXZ0KQ DMSN7GJ MN Matrix metalloproteinase-12 (MMP-12) DMSN7GJ MT DTT DMSN7GJ MA Inhibitor DMSN7GJ RN The identification of beta-hydroxy carboxylic acids as selective MMP-12 inhibitors. Bioorg Med Chem Lett. 2009 Oct 1;19(19):5760-3. DMSN7GJ RU https://pubmed.ncbi.nlm.nih.gov/19703773 DMSN7GJ DI DMSN7GJ DMSN7GJ DN (+/-)5-(biphenyl-4-yl)-3-hydroxypentanoic acid DMSN7GJ MI TTHY57M DMSN7GJ MN Matrix metalloproteinase-13 (MMP-13) DMSN7GJ MT DTT DMSN7GJ MA Inhibitor DMSN7GJ RN The identification of beta-hydroxy carboxylic acids as selective MMP-12 inhibitors. Bioorg Med Chem Lett. 2009 Oct 1;19(19):5760-3. DMSN7GJ RU https://pubmed.ncbi.nlm.nih.gov/19703773 DMSN7GJ DI DMSN7GJ DMSN7GJ DN (+/-)5-(biphenyl-4-yl)-3-hydroxypentanoic acid DMSN7GJ MI TTLM12X DMSN7GJ MN Matrix metalloproteinase-2 (MMP-2) DMSN7GJ MT DTT DMSN7GJ MA Inhibitor DMSN7GJ RN The identification of beta-hydroxy carboxylic acids as selective MMP-12 inhibitors. Bioorg Med Chem Lett. 2009 Oct 1;19(19):5760-3. DMSN7GJ RU https://pubmed.ncbi.nlm.nih.gov/19703773 DMSN7GJ DI DMSN7GJ DMSN7GJ DN (+/-)5-(biphenyl-4-yl)-3-hydroxypentanoic acid DMSN7GJ MI TT6X50U DMSN7GJ MN Matrix metalloproteinase-9 (MMP-9) DMSN7GJ MT DTT DMSN7GJ MA Inhibitor DMSN7GJ RN The identification of beta-hydroxy carboxylic acids as selective MMP-12 inhibitors. Bioorg Med Chem Lett. 2009 Oct 1;19(19):5760-3. DMSN7GJ RU https://pubmed.ncbi.nlm.nih.gov/19703773 DMSNWA6 DI DMSNWA6 DMSNWA6 DN (+/-)-5-amino-2-(mercaptomethyl)pentanoic acid DMSNWA6 MI TTP18AY DMSNWA6 MN Carboxypeptidase B2 (CPB2) DMSNWA6 MT DTT DMSNWA6 MA Inhibitor DMSNWA6 RN Discovery of potent & selective inhibitors of activated thrombin-activatable fibrinolysis inhibitor for the treatment of thrombosis. J Med Chem. 2007 Nov 29;50(24):6095-103. DMSNWA6 RU https://pubmed.ncbi.nlm.nih.gov/17990866 DMQP5U9 DI DMQP5U9 DMQP5U9 DN (+/-)-5'-deoxy-4'-fluoro-5'-methylthio-DADMe-ImmH DMQP5U9 MI TTMCF1Y DMQP5U9 MN Purine nucleoside phosphorylase (PNP) DMQP5U9 MT DTT DMQP5U9 MA Inhibitor DMQP5U9 RN Immucillins in custom catalytic-site cavities. Bioorg Med Chem Lett. 2008 Nov 15;18(22):5900-3. DMQP5U9 RU https://pubmed.ncbi.nlm.nih.gov/18778937 DM23W58 DI DM23W58 DM23W58 DN (+/-)-6-(2-chlorophenyl)cyclohex-3-enamine DM23W58 MI TTDIGC1 DM23W58 MN Dipeptidyl peptidase 4 (DPP-4) DM23W58 MT DTT DM23W58 MA Inhibitor DM23W58 RN Discovery of ((4R,5S)-5-amino-4-(2,4,5- trifluorophenyl)cyclohex-1-enyl)-(3- (trifluoromethyl)-5,6-dihydro- [1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)... J Med Chem. 2006 Nov 2;49(22):6439-42. DM23W58 RU https://pubmed.ncbi.nlm.nih.gov/17064063 DMKWBY8 DI DMKWBY8 DMKWBY8 DN (+/-)-7-fluoro-2-(4-fluorophenyl)chroman-4-one DMKWBY8 MI TTGP7BY DMKWBY8 MN Monoamine oxidase type B (MAO-B) DMKWBY8 MT DTT DMKWBY8 MA Inhibitor DMKWBY8 RN A new series of flavones, thioflavones, and flavanones as selective monoamine oxidase-B inhibitors. Bioorg Med Chem. 2010 Feb;18(3):1273-9. DMKWBY8 RU https://pubmed.ncbi.nlm.nih.gov/20045650 DMYHV9P DI DMYHV9P DMYHV9P DN (+/-)-7-fluoro-2-(4-methoxyphenyl)chroman-4-one DMYHV9P MI TTGP7BY DMYHV9P MN Monoamine oxidase type B (MAO-B) DMYHV9P MT DTT DMYHV9P MA Inhibitor DMYHV9P RN A new series of flavones, thioflavones, and flavanones as selective monoamine oxidase-B inhibitors. Bioorg Med Chem. 2010 Feb;18(3):1273-9. DMYHV9P RU https://pubmed.ncbi.nlm.nih.gov/20045650 DMJEBXA DI DMJEBXA DMJEBXA DN (+/-)-7-fluoro-2-phenylchroman-4-one DMJEBXA MI TTGP7BY DMJEBXA MN Monoamine oxidase type B (MAO-B) DMJEBXA MT DTT DMJEBXA MA Inhibitor DMJEBXA RN A new series of flavones, thioflavones, and flavanones as selective monoamine oxidase-B inhibitors. Bioorg Med Chem. 2010 Feb;18(3):1273-9. DMJEBXA RU https://pubmed.ncbi.nlm.nih.gov/20045650 DM4H1JO DI DM4H1JO DM4H1JO DN (+/-)-7-fluoro-2-p-tolylchroman-4-one DM4H1JO MI TTGP7BY DM4H1JO MN Monoamine oxidase type B (MAO-B) DM4H1JO MT DTT DM4H1JO MA Inhibitor DM4H1JO RN A new series of flavones, thioflavones, and flavanones as selective monoamine oxidase-B inhibitors. Bioorg Med Chem. 2010 Feb;18(3):1273-9. DM4H1JO RU https://pubmed.ncbi.nlm.nih.gov/20045650 DMYJGDK DI DMYJGDK DMYJGDK DN (+/-)-7-methoxy-2-(4-methoxyphenyl)chroman-4-one DMYJGDK MI TTSZLWK DMYJGDK MN Aromatase (CYP19A1) DMYJGDK MT DTT DMYJGDK MA Inhibitor DMYJGDK RN Synthesis and biological evaluation of (+/-)-abyssinone II and its analogues as aromatase inhibitors for chemoprevention of breast cancer. J Med Chem. 2007 Jun 14;50(12):2799-806. DMYJGDK RU https://pubmed.ncbi.nlm.nih.gov/17511439 DMYJGDK DI DMYJGDK DMYJGDK DN (+/-)-7-methoxy-2-(4-methoxyphenyl)chroman-4-one DMYJGDK MI TTGP7BY DMYJGDK MN Monoamine oxidase type B (MAO-B) DMYJGDK MT DTT DMYJGDK MA Inhibitor DMYJGDK RN A new series of flavones, thioflavones, and flavanones as selective monoamine oxidase-B inhibitors. Bioorg Med Chem. 2010 Feb;18(3):1273-9. DMYJGDK RU https://pubmed.ncbi.nlm.nih.gov/20045650 DMC0OKA DI DMC0OKA DMC0OKA DN (+/-)-7-methoxy-2-phenylchroman-4-one DMC0OKA MI TTSZLWK DMC0OKA MN Aromatase (CYP19A1) DMC0OKA MT DTT DMC0OKA MA Inhibitor DMC0OKA RN New 7,8-benzoflavanones as potent aromatase inhibitors: synthesis and biological evaluation. Bioorg Med Chem. 2008 Feb 1;16(3):1474-80. DMC0OKA RU https://pubmed.ncbi.nlm.nih.gov/18042388 DMC0OKA DI DMC0OKA DMC0OKA DN (+/-)-7-methoxy-2-phenylchroman-4-one DMC0OKA MI TTGP7BY DMC0OKA MN Monoamine oxidase type B (MAO-B) DMC0OKA MT DTT DMC0OKA MA Inhibitor DMC0OKA RN A new series of flavones, thioflavones, and flavanones as selective monoamine oxidase-B inhibitors. Bioorg Med Chem. 2010 Feb;18(3):1273-9. DMC0OKA RU https://pubmed.ncbi.nlm.nih.gov/20045650 DMJMTVQ DI DMJMTVQ DMJMTVQ DN (+/-)-7-methoxy-2-p-tolylchroman-4-one DMJMTVQ MI TTGP7BY DMJMTVQ MN Monoamine oxidase type B (MAO-B) DMJMTVQ MT DTT DMJMTVQ MA Inhibitor DMJMTVQ RN A new series of flavones, thioflavones, and flavanones as selective monoamine oxidase-B inhibitors. Bioorg Med Chem. 2010 Feb;18(3):1273-9. DMJMTVQ RU https://pubmed.ncbi.nlm.nih.gov/20045650 DMI3URD DI DMI3URD DMI3URD DN (+/-)-7-methyl-2-phenylchroman-4-one DMI3URD MI TTGP7BY DMI3URD MN Monoamine oxidase type B (MAO-B) DMI3URD MT DTT DMI3URD MA Inhibitor DMI3URD RN A new series of flavones, thioflavones, and flavanones as selective monoamine oxidase-B inhibitors. Bioorg Med Chem. 2010 Feb;18(3):1273-9. DMI3URD RU https://pubmed.ncbi.nlm.nih.gov/20045650 DMBN3WE DI DMBN3WE DMBN3WE DN (+/-)-7-methyl-2-p-tolylchroman-4-one DMBN3WE MI TTGP7BY DMBN3WE MN Monoamine oxidase type B (MAO-B) DMBN3WE MT DTT DMBN3WE MA Inhibitor DMBN3WE RN A new series of flavones, thioflavones, and flavanones as selective monoamine oxidase-B inhibitors. Bioorg Med Chem. 2010 Feb;18(3):1273-9. DMBN3WE RU https://pubmed.ncbi.nlm.nih.gov/20045650 DMY3J0B DI DMY3J0B DMY3J0B DN (+/-)-cis-2-CAMP DMY3J0B MI TT6XFEU DMY3J0B MN GABA(A) receptor rho1 (GABRR1) DMY3J0B MT DTT DMY3J0B MA Agonist DMY3J0B RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 420). DMY3J0B RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=420 DMY3J0B DI DMY3J0B DMY3J0B DN (+/-)-cis-2-CAMP DMY3J0B MI TTQMXLS DMY3J0B MN GABA(A) receptor rho2 (GABRR2) DMY3J0B MT DTT DMY3J0B MA Agonist DMY3J0B RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 421). DMY3J0B RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=421 DMY3J0B DI DMY3J0B DMY3J0B DN (+/-)-cis-2-CAMP DMY3J0B MI TT4N6D8 DMY3J0B MN GABA(A) receptor rho3 (GABRR3) DMY3J0B MT DTT DMY3J0B MA Agonist DMY3J0B RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 422). DMY3J0B RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=422 DMAHO9M DI DMAHO9M DMAHO9M DN (+/-)-cis-H2-PAT DMAHO9M MI TTTIBOJ DMAHO9M MN Histamine H1 receptor (H1R) DMAHO9M MT DTT DMAHO9M MA Antagonist DMAHO9M RN A novel phenylaminotetralin radioligand reveals a subpopulation of histamine H(1) receptors. J Pharmacol Exp Ther. 2002 Jul;302(1):328-36. DMAHO9M RU https://pubmed.ncbi.nlm.nih.gov/12065734 DMBSH5L DI DMBSH5L DMBSH5L DN (+/-)-Daedalin A DMBSH5L MI TTULVH8 DMBSH5L MN Tyrosinase (TYR) DMBSH5L MT DTT DMBSH5L MA Inhibitor DMBSH5L RN Asymmetric syntheses of daedalin A and quercinol and their tyrosinase inhibitory activity. Bioorg Med Chem Lett. 2010 Feb 1;20(3):1063-4. DMBSH5L RU https://pubmed.ncbi.nlm.nih.gov/20036119 DM0L3GE DI DM0L3GE DM0L3GE DN (+/-)-nantenine DM0L3GE MI TTK8CXU DM0L3GE MN 5-HT 1B receptor (HTR1B) DM0L3GE MT DTT DM0L3GE MA Inhibitor DM0L3GE RN Synthetic studies and pharmacological evaluations on the MDMA ('Ecstasy') antagonist nantenine. Bioorg Med Chem Lett. 2010 Jan 15;20(2):628-31. DM0L3GE RU https://pubmed.ncbi.nlm.nih.gov/19963380 DM0L3GE DI DM0L3GE DM0L3GE DN (+/-)-nantenine DM0L3GE MI TT6MSOK DM0L3GE MN 5-HT 1D receptor (HTR1D) DM0L3GE MT DTT DM0L3GE MA Inhibitor DM0L3GE RN Synthetic studies and pharmacological evaluations on the MDMA ('Ecstasy') antagonist nantenine. Bioorg Med Chem Lett. 2010 Jan 15;20(2):628-31. DM0L3GE RU https://pubmed.ncbi.nlm.nih.gov/19963380 DM0L3GE DI DM0L3GE DM0L3GE DN (+/-)-nantenine DM0L3GE MI TTJQOD7 DM0L3GE MN 5-HT 2A receptor (HTR2A) DM0L3GE MT DTT DM0L3GE MA Inhibitor DM0L3GE RN Synthetic studies and pharmacological evaluations on the MDMA ('Ecstasy') antagonist nantenine. Bioorg Med Chem Lett. 2010 Jan 15;20(2):628-31. DM0L3GE RU https://pubmed.ncbi.nlm.nih.gov/19963380 DM0L3GE DI DM0L3GE DM0L3GE DN (+/-)-nantenine DM0L3GE MI TT0K1SC DM0L3GE MN 5-HT 2B receptor (HTR2B) DM0L3GE MT DTT DM0L3GE MA Inhibitor DM0L3GE RN Synthetic studies and pharmacological evaluations on the MDMA ('Ecstasy') antagonist nantenine. Bioorg Med Chem Lett. 2010 Jan 15;20(2):628-31. DM0L3GE RU https://pubmed.ncbi.nlm.nih.gov/19963380 DM0L3GE DI DM0L3GE DM0L3GE DN (+/-)-nantenine DM0L3GE MI TTWJBZ5 DM0L3GE MN 5-HT 2C receptor (HTR2C) DM0L3GE MT DTT DM0L3GE MA Inhibitor DM0L3GE RN Synthetic studies and pharmacological evaluations on the MDMA ('Ecstasy') antagonist nantenine. Bioorg Med Chem Lett. 2010 Jan 15;20(2):628-31. DM0L3GE RU https://pubmed.ncbi.nlm.nih.gov/19963380 DM0L3GE DI DM0L3GE DM0L3GE DN (+/-)-nantenine DM0L3GE MI TTRUFDT DM0L3GE MN 5-HT 5A receptor (HTR5A) DM0L3GE MT DTT DM0L3GE MA Inhibitor DM0L3GE RN Synthetic studies and pharmacological evaluations on the MDMA ('Ecstasy') antagonist nantenine. Bioorg Med Chem Lett. 2010 Jan 15;20(2):628-31. DM0L3GE RU https://pubmed.ncbi.nlm.nih.gov/19963380 DM0L3GE DI DM0L3GE DM0L3GE DN (+/-)-nantenine DM0L3GE MI TTJS8PY DM0L3GE MN 5-HT 6 receptor (HTR6) DM0L3GE MT DTT DM0L3GE MA Inhibitor DM0L3GE RN Synthetic studies and pharmacological evaluations on the MDMA ('Ecstasy') antagonist nantenine. Bioorg Med Chem Lett. 2010 Jan 15;20(2):628-31. DM0L3GE RU https://pubmed.ncbi.nlm.nih.gov/19963380 DM0L3GE DI DM0L3GE DM0L3GE DN (+/-)-nantenine DM0L3GE MI TTO9X1H DM0L3GE MN 5-HT 7 receptor (HTR7) DM0L3GE MT DTT DM0L3GE MA Inhibitor DM0L3GE RN Synthetic studies and pharmacological evaluations on the MDMA ('Ecstasy') antagonist nantenine. Bioorg Med Chem Lett. 2010 Jan 15;20(2):628-31. DM0L3GE RU https://pubmed.ncbi.nlm.nih.gov/19963380 DM0L3GE DI DM0L3GE DM0L3GE DN (+/-)-nantenine DM0L3GE MI TTNGILX DM0L3GE MN Adrenergic receptor alpha-1A (ADRA1A) DM0L3GE MT DTT DM0L3GE MA Inhibitor DM0L3GE RN Synthetic studies and pharmacological evaluations on the MDMA ('Ecstasy') antagonist nantenine. Bioorg Med Chem Lett. 2010 Jan 15;20(2):628-31. DM0L3GE RU https://pubmed.ncbi.nlm.nih.gov/19963380 DM0L3GE DI DM0L3GE DM0L3GE DN (+/-)-nantenine DM0L3GE MI TTBRKXS DM0L3GE MN Adrenergic receptor alpha-1B (ADRA1B) DM0L3GE MT DTT DM0L3GE MA Inhibitor DM0L3GE RN Synthetic studies and pharmacological evaluations on the MDMA ('Ecstasy') antagonist nantenine. Bioorg Med Chem Lett. 2010 Jan 15;20(2):628-31. DM0L3GE RU https://pubmed.ncbi.nlm.nih.gov/19963380 DM0L3GE DI DM0L3GE DM0L3GE DN (+/-)-nantenine DM0L3GE MI TT34BHT DM0L3GE MN Adrenergic receptor alpha-1D (ADRA1D) DM0L3GE MT DTT DM0L3GE MA Inhibitor DM0L3GE RN Synthetic studies and pharmacological evaluations on the MDMA ('Ecstasy') antagonist nantenine. Bioorg Med Chem Lett. 2010 Jan 15;20(2):628-31. DM0L3GE RU https://pubmed.ncbi.nlm.nih.gov/19963380 DM0L3GE DI DM0L3GE DM0L3GE DN (+/-)-nantenine DM0L3GE MI TTWG9A4 DM0L3GE MN Adrenergic receptor alpha-2A (ADRA2A) DM0L3GE MT DTT DM0L3GE MA Inhibitor DM0L3GE RN Synthetic studies and pharmacological evaluations on the MDMA ('Ecstasy') antagonist nantenine. Bioorg Med Chem Lett. 2010 Jan 15;20(2):628-31. DM0L3GE RU https://pubmed.ncbi.nlm.nih.gov/19963380 DM0L3GE DI DM0L3GE DM0L3GE DN (+/-)-nantenine DM0L3GE MI TTWM4TY DM0L3GE MN Adrenergic receptor alpha-2B (ADRA2B) DM0L3GE MT DTT DM0L3GE MA Inhibitor DM0L3GE RN Synthetic studies and pharmacological evaluations on the MDMA ('Ecstasy') antagonist nantenine. Bioorg Med Chem Lett. 2010 Jan 15;20(2):628-31. DM0L3GE RU https://pubmed.ncbi.nlm.nih.gov/19963380 DM0L3GE DI DM0L3GE DM0L3GE DN (+/-)-nantenine DM0L3GE MI TT2NUT5 DM0L3GE MN Adrenergic receptor alpha-2C (ADRA2C) DM0L3GE MT DTT DM0L3GE MA Inhibitor DM0L3GE RN Synthetic studies and pharmacological evaluations on the MDMA ('Ecstasy') antagonist nantenine. Bioorg Med Chem Lett. 2010 Jan 15;20(2):628-31. DM0L3GE RU https://pubmed.ncbi.nlm.nih.gov/19963380 DM0L3GE DI DM0L3GE DM0L3GE DN (+/-)-nantenine DM0L3GE MI TTR6W5O DM0L3GE MN Adrenergic receptor beta-1 (ADRB1) DM0L3GE MT DTT DM0L3GE MA Inhibitor DM0L3GE RN Synthetic studies and pharmacological evaluations on the MDMA ('Ecstasy') antagonist nantenine. Bioorg Med Chem Lett. 2010 Jan 15;20(2):628-31. DM0L3GE RU https://pubmed.ncbi.nlm.nih.gov/19963380 DM0L3GE DI DM0L3GE DM0L3GE DN (+/-)-nantenine DM0L3GE MI TTZFYLI DM0L3GE MN Dopamine D1 receptor (D1R) DM0L3GE MT DTT DM0L3GE MA Inhibitor DM0L3GE RN Synthetic studies and pharmacological evaluations on the MDMA ('Ecstasy') antagonist nantenine. Bioorg Med Chem Lett. 2010 Jan 15;20(2):628-31. DM0L3GE RU https://pubmed.ncbi.nlm.nih.gov/19963380 DM0L3GE DI DM0L3GE DM0L3GE DN (+/-)-nantenine DM0L3GE MI TTEX248 DM0L3GE MN Dopamine D2 receptor (D2R) DM0L3GE MT DTT DM0L3GE MA Inhibitor DM0L3GE RN Synthetic studies and pharmacological evaluations on the MDMA ('Ecstasy') antagonist nantenine. Bioorg Med Chem Lett. 2010 Jan 15;20(2):628-31. DM0L3GE RU https://pubmed.ncbi.nlm.nih.gov/19963380 DM0L3GE DI DM0L3GE DM0L3GE DN (+/-)-nantenine DM0L3GE MI TT4C8EA DM0L3GE MN Dopamine D3 receptor (D3R) DM0L3GE MT DTT DM0L3GE MA Inhibitor DM0L3GE RN Synthetic studies and pharmacological evaluations on the MDMA ('Ecstasy') antagonist nantenine. Bioorg Med Chem Lett. 2010 Jan 15;20(2):628-31. DM0L3GE RU https://pubmed.ncbi.nlm.nih.gov/19963380 DM0L3GE DI DM0L3GE DM0L3GE DN (+/-)-nantenine DM0L3GE MI TTE0A2F DM0L3GE MN Dopamine D4 receptor (D4R) DM0L3GE MT DTT DM0L3GE MA Inhibitor DM0L3GE RN Synthetic studies and pharmacological evaluations on the MDMA ('Ecstasy') antagonist nantenine. Bioorg Med Chem Lett. 2010 Jan 15;20(2):628-31. DM0L3GE RU https://pubmed.ncbi.nlm.nih.gov/19963380 DM0L3GE DI DM0L3GE DM0L3GE DN (+/-)-nantenine DM0L3GE MI TTS2PH3 DM0L3GE MN Dopamine D5 receptor (D5R) DM0L3GE MT DTT DM0L3GE MA Inhibitor DM0L3GE RN Synthetic studies and pharmacological evaluations on the MDMA ('Ecstasy') antagonist nantenine. Bioorg Med Chem Lett. 2010 Jan 15;20(2):628-31. DM0L3GE RU https://pubmed.ncbi.nlm.nih.gov/19963380 DM0L3GE DI DM0L3GE DM0L3GE DN (+/-)-nantenine DM0L3GE MI TTQHJ1K DM0L3GE MN Histamine H2 receptor (H2R) DM0L3GE MT DTT DM0L3GE MA Inhibitor DM0L3GE RN Synthetic studies and pharmacological evaluations on the MDMA ('Ecstasy') antagonist nantenine. Bioorg Med Chem Lett. 2010 Jan 15;20(2):628-31. DM0L3GE RU https://pubmed.ncbi.nlm.nih.gov/19963380 DM0L3GE DI DM0L3GE DM0L3GE DN (+/-)-nantenine DM0L3GE MI TTKWM86 DM0L3GE MN Opioid receptor mu (MOP) DM0L3GE MT DTT DM0L3GE MA Inhibitor DM0L3GE RN Synthetic studies and pharmacological evaluations on the MDMA ('Ecstasy') antagonist nantenine. Bioorg Med Chem Lett. 2010 Jan 15;20(2):628-31. DM0L3GE RU https://pubmed.ncbi.nlm.nih.gov/19963380 DM0L3GE DI DM0L3GE DM0L3GE DN (+/-)-nantenine DM0L3GE MI TT3ROYC DM0L3GE MN Serotonin transporter (SERT) DM0L3GE MT DTT DM0L3GE MA Inhibitor DM0L3GE RN Synthetic studies and pharmacological evaluations on the MDMA ('Ecstasy') antagonist nantenine. Bioorg Med Chem Lett. 2010 Jan 15;20(2):628-31. DM0L3GE RU https://pubmed.ncbi.nlm.nih.gov/19963380 DM8023E DI DM8023E DM8023E DN (+/-)-oxiran-2-ylmethyl (9Z)-hexadec-9-enoate DM8023E MI TTDP1UC DM8023E MN Fatty acid amide hydrolase (FAAH) DM8023E MT DTT DM8023E MA Inhibitor DM8023E RN Structure-activity relationship of a series of inhibitors of monoacylglycerol hydrolysis--comparison with effects upon fatty acid amide hydrolase. J Med Chem. 2007 Oct 4;50(20):5012-23. DM8023E RU https://pubmed.ncbi.nlm.nih.gov/17764163 DMI5R3E DI DMI5R3E DMI5R3E DN (+/-)-oxiran-2-ylmethyl (9Z)-octadec-9-enoate DMI5R3E MI TTDP1UC DMI5R3E MN Fatty acid amide hydrolase (FAAH) DMI5R3E MT DTT DMI5R3E MA Inhibitor DMI5R3E RN Structure-activity relationship of a series of inhibitors of monoacylglycerol hydrolysis--comparison with effects upon fatty acid amide hydrolase. J Med Chem. 2007 Oct 4;50(20):5012-23. DMI5R3E RU https://pubmed.ncbi.nlm.nih.gov/17764163 DMFSZ8H DI DMFSZ8H DMFSZ8H DN (+/-)-threo-3',4'-Dichloromethylphenidate amide DMFSZ8H MI TTVBI8W DMFSZ8H MN Dopamine transporter (DAT) DMFSZ8H MT DTT DMFSZ8H MA Inhibitor DMFSZ8H RN Quantitative structure-activity relationship studies of threo-methylphenidate analogs. Bioorg Med Chem. 2010 Oct 15;18(20):7221-38. DMFSZ8H RU https://pubmed.ncbi.nlm.nih.gov/20846865 DM5MLZ0 DI DM5MLZ0 DM5MLZ0 DN (+/-)-threo-3',4'-Dichlororitalinol methyl ether DM5MLZ0 MI TTVBI8W DM5MLZ0 MN Dopamine transporter (DAT) DM5MLZ0 MT DTT DM5MLZ0 MA Inhibitor DM5MLZ0 RN Quantitative structure-activity relationship studies of threo-methylphenidate analogs. Bioorg Med Chem. 2010 Oct 15;18(20):7221-38. DM5MLZ0 RU https://pubmed.ncbi.nlm.nih.gov/20846865 DM4UQBI DI DM4UQBI DM4UQBI DN (+/-)-threo-3',5'-Dichloromethylphenidate DM4UQBI MI TTVBI8W DM4UQBI MN Dopamine transporter (DAT) DM4UQBI MT DTT DM4UQBI MA Inhibitor DM4UQBI RN Quantitative structure-activity relationship studies of threo-methylphenidate analogs. Bioorg Med Chem. 2010 Oct 15;18(20):7221-38. DM4UQBI RU https://pubmed.ncbi.nlm.nih.gov/20846865 DMUWKNX DI DMUWKNX DMUWKNX DN (+/-)-threo-3',5'-Dimethylmethylphenidate DMUWKNX MI TTVBI8W DMUWKNX MN Dopamine transporter (DAT) DMUWKNX MT DTT DMUWKNX MA Inhibitor DMUWKNX RN Quantitative structure-activity relationship studies of threo-methylphenidate analogs. Bioorg Med Chem. 2010 Oct 15;18(20):7221-38. DMUWKNX RU https://pubmed.ncbi.nlm.nih.gov/20846865 DM3O4FI DI DM3O4FI DM3O4FI DN (+/-)-threo-3-Fluororitalinol DM3O4FI MI TTVBI8W DM3O4FI MN Dopamine transporter (DAT) DM3O4FI MT DTT DM3O4FI MA Inhibitor DM3O4FI RN Quantitative structure-activity relationship studies of threo-methylphenidate analogs. Bioorg Med Chem. 2010 Oct 15;18(20):7221-38. DM3O4FI RU https://pubmed.ncbi.nlm.nih.gov/20846865 DMU5T28 DI DMU5T28 DMU5T28 DN (+/-)-threo-4'-Ethylmethylphenidate DMU5T28 MI TTVBI8W DMU5T28 MN Dopamine transporter (DAT) DMU5T28 MT DTT DMU5T28 MA Inhibitor DMU5T28 RN Quantitative structure-activity relationship studies of threo-methylphenidate analogs. Bioorg Med Chem. 2010 Oct 15;18(20):7221-38. DMU5T28 RU https://pubmed.ncbi.nlm.nih.gov/20846865 DM9TSW0 DI DM9TSW0 DM9TSW0 DN (+/-)-threo-Benzylphenidate DM9TSW0 MI TTVBI8W DM9TSW0 MN Dopamine transporter (DAT) DM9TSW0 MT DTT DM9TSW0 MA Inhibitor DM9TSW0 RN Quantitative structure-activity relationship studies of threo-methylphenidate analogs. Bioorg Med Chem. 2010 Oct 15;18(20):7221-38. DM9TSW0 RU https://pubmed.ncbi.nlm.nih.gov/20846865 DMRZOVP DI DMRZOVP DMRZOVP DN (+/-)-threo-Methylphenidate amide DMRZOVP MI TTVBI8W DMRZOVP MN Dopamine transporter (DAT) DMRZOVP MT DTT DMRZOVP MA Inhibitor DMRZOVP RN Quantitative structure-activity relationship studies of threo-methylphenidate analogs. Bioorg Med Chem. 2010 Oct 15;18(20):7221-38. DMRZOVP RU https://pubmed.ncbi.nlm.nih.gov/20846865 DM80JOH DI DM80JOH DM80JOH DN (+/-)-threo-N-(2-Chlorobenzyl)methylphenidate DM80JOH MI TTVBI8W DM80JOH MN Dopamine transporter (DAT) DM80JOH MT DTT DM80JOH MA Inhibitor DM80JOH RN Quantitative structure-activity relationship studies of threo-methylphenidate analogs. Bioorg Med Chem. 2010 Oct 15;18(20):7221-38. DM80JOH RU https://pubmed.ncbi.nlm.nih.gov/20846865 DM6CWBO DI DM6CWBO DM6CWBO DN (+/-)-threo-N-(2-Methylfuran)methylphenidate DM6CWBO MI TTVBI8W DM6CWBO MN Dopamine transporter (DAT) DM6CWBO MT DTT DM6CWBO MA Inhibitor DM6CWBO RN Quantitative structure-activity relationship studies of threo-methylphenidate analogs. Bioorg Med Chem. 2010 Oct 15;18(20):7221-38. DM6CWBO RU https://pubmed.ncbi.nlm.nih.gov/20846865 DMN6ZX9 DI DMN6ZX9 DMN6ZX9 DN (+/-)-threo-N-(2-Methylpyridine)methylphenidate DMN6ZX9 MI TTVBI8W DMN6ZX9 MN Dopamine transporter (DAT) DMN6ZX9 MT DTT DMN6ZX9 MA Inhibitor DMN6ZX9 RN Quantitative structure-activity relationship studies of threo-methylphenidate analogs. Bioorg Med Chem. 2010 Oct 15;18(20):7221-38. DMN6ZX9 RU https://pubmed.ncbi.nlm.nih.gov/20846865 DMWUGSV DI DMWUGSV DMWUGSV DN (+/-)-threo-N-(2-Methylthiopene)methylphenidate DMWUGSV MI TTVBI8W DMWUGSV MN Dopamine transporter (DAT) DMWUGSV MT DTT DMWUGSV MA Inhibitor DMWUGSV RN Quantitative structure-activity relationship studies of threo-methylphenidate analogs. Bioorg Med Chem. 2010 Oct 15;18(20):7221-38. DMWUGSV RU https://pubmed.ncbi.nlm.nih.gov/20846865 DM2WRED DI DM2WRED DM2WRED DN (+/-)-threo-N-(2-Phenylethyl)methylphenidate DM2WRED MI TTVBI8W DM2WRED MN Dopamine transporter (DAT) DM2WRED MT DTT DM2WRED MA Inhibitor DM2WRED RN Quantitative structure-activity relationship studies of threo-methylphenidate analogs. Bioorg Med Chem. 2010 Oct 15;18(20):7221-38. DM2WRED RU https://pubmed.ncbi.nlm.nih.gov/20846865 DM9Y3MT DI DM9Y3MT DM9Y3MT DN (+/-)-threo-N-(2-Phenylethyl)ritalinol DM9Y3MT MI TTVBI8W DM9Y3MT MN Dopamine transporter (DAT) DM9Y3MT MT DTT DM9Y3MT MA Inhibitor DM9Y3MT RN Quantitative structure-activity relationship studies of threo-methylphenidate analogs. Bioorg Med Chem. 2010 Oct 15;18(20):7221-38. DM9Y3MT RU https://pubmed.ncbi.nlm.nih.gov/20846865 DMU08WO DI DMU08WO DMU08WO DN (+/-)-threo-N-(3-Chlorobenzyl)methylphenidate DMU08WO MI TTVBI8W DMU08WO MN Dopamine transporter (DAT) DMU08WO MT DTT DMU08WO MA Inhibitor DMU08WO RN Quantitative structure-activity relationship studies of threo-methylphenidate analogs. Bioorg Med Chem. 2010 Oct 15;18(20):7221-38. DMU08WO RU https://pubmed.ncbi.nlm.nih.gov/20846865 DMHPE4L DI DMHPE4L DMHPE4L DN (+/-)-threo-N-(3-Methylfuran)methylphenidate DMHPE4L MI TTVBI8W DMHPE4L MN Dopamine transporter (DAT) DMHPE4L MT DTT DMHPE4L MA Inhibitor DMHPE4L RN Quantitative structure-activity relationship studies of threo-methylphenidate analogs. Bioorg Med Chem. 2010 Oct 15;18(20):7221-38. DMHPE4L RU https://pubmed.ncbi.nlm.nih.gov/20846865 DMDMTZK DI DMDMTZK DMDMTZK DN (+/-)-threo-N-(3-Methylpyridine)methylphenidate DMDMTZK MI TTVBI8W DMDMTZK MN Dopamine transporter (DAT) DMDMTZK MT DTT DMDMTZK MA Inhibitor DMDMTZK RN Quantitative structure-activity relationship studies of threo-methylphenidate analogs. Bioorg Med Chem. 2010 Oct 15;18(20):7221-38. DMDMTZK RU https://pubmed.ncbi.nlm.nih.gov/20846865 DMIJ7PC DI DMIJ7PC DMIJ7PC DN (+/-)-threo-N-(3-Methylthiopene)methylphenidate DMIJ7PC MI TTVBI8W DMIJ7PC MN Dopamine transporter (DAT) DMIJ7PC MT DTT DMIJ7PC MA Inhibitor DMIJ7PC RN Quantitative structure-activity relationship studies of threo-methylphenidate analogs. Bioorg Med Chem. 2010 Oct 15;18(20):7221-38. DMIJ7PC RU https://pubmed.ncbi.nlm.nih.gov/20846865 DMD926H DI DMD926H DMD926H DN (+/-)-threo-N-(3-Phenylpropyl)methylphenidate DMD926H MI TTVBI8W DMD926H MN Dopamine transporter (DAT) DMD926H MT DTT DMD926H MA Inhibitor DMD926H RN Quantitative structure-activity relationship studies of threo-methylphenidate analogs. Bioorg Med Chem. 2010 Oct 15;18(20):7221-38. DMD926H RU https://pubmed.ncbi.nlm.nih.gov/20846865 DMVP183 DI DMVP183 DMVP183 DN (+/-)-threo-N-(3-Phenylpropyl)ritalinol DMVP183 MI TTVBI8W DMVP183 MN Dopamine transporter (DAT) DMVP183 MT DTT DMVP183 MA Inhibitor DMVP183 RN Quantitative structure-activity relationship studies of threo-methylphenidate analogs. Bioorg Med Chem. 2010 Oct 15;18(20):7221-38. DMVP183 RU https://pubmed.ncbi.nlm.nih.gov/20846865 DM3HWQY DI DM3HWQY DM3HWQY DN (+/-)-threo-N-(4-Chlorobenzyl)methylphenidate DM3HWQY MI TTVBI8W DM3HWQY MN Dopamine transporter (DAT) DM3HWQY MT DTT DM3HWQY MA Inhibitor DM3HWQY RN Quantitative structure-activity relationship studies of threo-methylphenidate analogs. Bioorg Med Chem. 2010 Oct 15;18(20):7221-38. DM3HWQY RU https://pubmed.ncbi.nlm.nih.gov/20846865 DMHIKD2 DI DMHIKD2 DMHIKD2 DN (+/-)-threo-N-(4-Methoxybenzyl)methylphenidate DMHIKD2 MI TTVBI8W DMHIKD2 MN Dopamine transporter (DAT) DMHIKD2 MT DTT DMHIKD2 MA Inhibitor DMHIKD2 RN Quantitative structure-activity relationship studies of threo-methylphenidate analogs. Bioorg Med Chem. 2010 Oct 15;18(20):7221-38. DMHIKD2 RU https://pubmed.ncbi.nlm.nih.gov/20846865 DM9QIAL DI DM9QIAL DM9QIAL DN (+/-)-threo-N-(4-Methylpyridine)methylphenidate DM9QIAL MI TTVBI8W DM9QIAL MN Dopamine transporter (DAT) DM9QIAL MT DTT DM9QIAL MA Inhibitor DM9QIAL RN Quantitative structure-activity relationship studies of threo-methylphenidate analogs. Bioorg Med Chem. 2010 Oct 15;18(20):7221-38. DM9QIAL RU https://pubmed.ncbi.nlm.nih.gov/20846865 DMB3JY8 DI DMB3JY8 DMB3JY8 DN (+/-)-threo-N-(4-Nitrobenzyl)methylphenidate DMB3JY8 MI TTVBI8W DMB3JY8 MN Dopamine transporter (DAT) DMB3JY8 MT DTT DMB3JY8 MA Inhibitor DMB3JY8 RN Quantitative structure-activity relationship studies of threo-methylphenidate analogs. Bioorg Med Chem. 2010 Oct 15;18(20):7221-38. DMB3JY8 RU https://pubmed.ncbi.nlm.nih.gov/20846865 DMK6IJW DI DMK6IJW DMK6IJW DN (+/-)-threo-N-(4-Phenylbutyl)methylphenidate DMK6IJW MI TTVBI8W DMK6IJW MN Dopamine transporter (DAT) DMK6IJW MT DTT DMK6IJW MA Inhibitor DMK6IJW RN Quantitative structure-activity relationship studies of threo-methylphenidate analogs. Bioorg Med Chem. 2010 Oct 15;18(20):7221-38. DMK6IJW RU https://pubmed.ncbi.nlm.nih.gov/20846865 DMG3FA1 DI DMG3FA1 DMG3FA1 DN (+/-)-threo-N-(4-Phenylbutyl)ritalinol DMG3FA1 MI TTVBI8W DMG3FA1 MN Dopamine transporter (DAT) DMG3FA1 MT DTT DMG3FA1 MA Inhibitor DMG3FA1 RN Quantitative structure-activity relationship studies of threo-methylphenidate analogs. Bioorg Med Chem. 2010 Oct 15;18(20):7221-38. DMG3FA1 RU https://pubmed.ncbi.nlm.nih.gov/20846865 DMHNQO9 DI DMHNQO9 DMHNQO9 DN (+/-)-threo-N-(5-Phenylpentyl)methylphenidate DMHNQO9 MI TTVBI8W DMHNQO9 MN Dopamine transporter (DAT) DMHNQO9 MT DTT DMHNQO9 MA Inhibitor DMHNQO9 RN Quantitative structure-activity relationship studies of threo-methylphenidate analogs. Bioorg Med Chem. 2010 Oct 15;18(20):7221-38. DMHNQO9 RU https://pubmed.ncbi.nlm.nih.gov/20846865 DMG1K5H DI DMG1K5H DMG1K5H DN (+/-)-threo-N-(6-Phenylhexyl)methylphenidate DMG1K5H MI TTVBI8W DMG1K5H MN Dopamine transporter (DAT) DMG1K5H MT DTT DMG1K5H MA Inhibitor DMG1K5H RN Quantitative structure-activity relationship studies of threo-methylphenidate analogs. Bioorg Med Chem. 2010 Oct 15;18(20):7221-38. DMG1K5H RU https://pubmed.ncbi.nlm.nih.gov/20846865 DMYNO71 DI DMYNO71 DMYNO71 DN (+/-)-threo-N-Allylmethylphenidate DMYNO71 MI TTVBI8W DMYNO71 MN Dopamine transporter (DAT) DMYNO71 MT DTT DMYNO71 MA Inhibitor DMYNO71 RN Quantitative structure-activity relationship studies of threo-methylphenidate analogs. Bioorg Med Chem. 2010 Oct 15;18(20):7221-38. DMYNO71 RU https://pubmed.ncbi.nlm.nih.gov/20846865 DMOJXCK DI DMOJXCK DMOJXCK DN (+/-)-threo-N-Benzyl-3',4'-dichlororitalinol DMOJXCK MI TTVBI8W DMOJXCK MN Dopamine transporter (DAT) DMOJXCK MT DTT DMOJXCK MA Inhibitor DMOJXCK RN Quantitative structure-activity relationship studies of threo-methylphenidate analogs. Bioorg Med Chem. 2010 Oct 15;18(20):7221-38. DMOJXCK RU https://pubmed.ncbi.nlm.nih.gov/20846865 DM15LE0 DI DM15LE0 DM15LE0 DN (+/-)-threo-N-Benzyl-3'-chloromethylphenidate DM15LE0 MI TTVBI8W DM15LE0 MN Dopamine transporter (DAT) DM15LE0 MT DTT DM15LE0 MA Inhibitor DM15LE0 RN Quantitative structure-activity relationship studies of threo-methylphenidate analogs. Bioorg Med Chem. 2010 Oct 15;18(20):7221-38. DM15LE0 RU https://pubmed.ncbi.nlm.nih.gov/20846865 DMUACDH DI DMUACDH DMUACDH DN (+/-)-threo-N-Benzylmethylphenidate amide DMUACDH MI TTVBI8W DMUACDH MN Dopamine transporter (DAT) DMUACDH MT DTT DMUACDH MA Inhibitor DMUACDH RN Quantitative structure-activity relationship studies of threo-methylphenidate analogs. Bioorg Med Chem. 2010 Oct 15;18(20):7221-38. DMUACDH RU https://pubmed.ncbi.nlm.nih.gov/20846865 DM6D18M DI DM6D18M DM6D18M DN (+/-)-threo-N-Methyl-30-methylmethylphenidate DM6D18M MI TTVBI8W DM6D18M MN Dopamine transporter (DAT) DM6D18M MT DTT DM6D18M MA Inhibitor DM6D18M RN Quantitative structure-activity relationship studies of threo-methylphenidate analogs. Bioorg Med Chem. 2010 Oct 15;18(20):7221-38. DM6D18M RU https://pubmed.ncbi.nlm.nih.gov/20846865 DMYE0MZ DI DMYE0MZ DMYE0MZ DN (+/-)-threo-N-Propargylmethylphenidate DMYE0MZ MI TTVBI8W DMYE0MZ MN Dopamine transporter (DAT) DMYE0MZ MT DTT DMYE0MZ MA Inhibitor DMYE0MZ RN Quantitative structure-activity relationship studies of threo-methylphenidate analogs. Bioorg Med Chem. 2010 Oct 15;18(20):7221-38. DMYE0MZ RU https://pubmed.ncbi.nlm.nih.gov/20846865 DMM2QOX DI DMM2QOX DMM2QOX DN (+/-)-TRANS-U-50488 METHANESULFONATE DMM2QOX MI TTKWM86 DMM2QOX MN Opioid receptor mu (MOP) DMM2QOX MT DTT DMM2QOX MA Inhibitor DMM2QOX RN Akuammine and dihydroakuammine, two indolomonoterpene alkaloids displaying affinity for opioid receptors. J Nat Prod. 1992 Mar;55(3):380-4. DMM2QOX RU https://pubmed.ncbi.nlm.nih.gov/1317407 DMDK59X DI DMDK59X DMDK59X DN (1,1-Difluoro-pentadecyl)-phosphonic acid DMDK59X MI TTQ6S1K DMDK59X MN Lysophosphatidic acid receptor 1 (LPAR1) DMDK59X MT DTT DMDK59X MA Inhibitor DMDK59X RN Synthesis, structure-activity relationships, and biological evaluation of fatty alcohol phosphates as lysophosphatidic acid receptor ligands, activ... J Med Chem. 2005 Jul 28;48(15):4919-30. DMDK59X RU https://pubmed.ncbi.nlm.nih.gov/16033271 DMF6WHC DI DMF6WHC DMF6WHC DN (1,2,3,4-Tetrahydro-isoquinolin-3-yl)-methanol DMF6WHC MI TTWG9A4 DMF6WHC MN Adrenergic receptor alpha-2A (ADRA2A) DMF6WHC MT DTT DMF6WHC MA Inhibitor DMF6WHC RN 3,7-Disubstituted-1,2,3,4-tetrahydroisoquinolines display remarkable potency and selectivity as inhibitors of phenylethanolamine N-methyltransferas... J Med Chem. 1999 Jun 3;42(11):1982-90. DMF6WHC RU https://pubmed.ncbi.nlm.nih.gov/10354406 DMF6WHC DI DMF6WHC DMF6WHC DN (1,2,3,4-Tetrahydro-isoquinolin-3-yl)-methanol DMF6WHC MI TTWM4TY DMF6WHC MN Adrenergic receptor alpha-2B (ADRA2B) DMF6WHC MT DTT DMF6WHC MA Inhibitor DMF6WHC RN 3,7-Disubstituted-1,2,3,4-tetrahydroisoquinolines display remarkable potency and selectivity as inhibitors of phenylethanolamine N-methyltransferas... J Med Chem. 1999 Jun 3;42(11):1982-90. DMF6WHC RU https://pubmed.ncbi.nlm.nih.gov/10354406 DMF6WHC DI DMF6WHC DMF6WHC DN (1,2,3,4-Tetrahydro-isoquinolin-3-yl)-methanol DMF6WHC MI TT2NUT5 DMF6WHC MN Adrenergic receptor alpha-2C (ADRA2C) DMF6WHC MT DTT DMF6WHC MA Inhibitor DMF6WHC RN 3,7-Disubstituted-1,2,3,4-tetrahydroisoquinolines display remarkable potency and selectivity as inhibitors of phenylethanolamine N-methyltransferas... J Med Chem. 1999 Jun 3;42(11):1982-90. DMF6WHC RU https://pubmed.ncbi.nlm.nih.gov/10354406 DM2J9RI DI DM2J9RI DM2J9RI DN (10H-phenothiazin-10-yl)(m-tolyl)methanone DM2J9RI MI TTEB0GD DM2J9RI MN Cholinesterase (BCHE) DM2J9RI MT DTT DM2J9RI MA Inhibitor DM2J9RI RN Selective reversible inhibition of human butyrylcholinesterase by aryl amide derivatives of phenothiazine. Bioorg Med Chem. 2007 Oct 1;15(19):6367-78. DM2J9RI RU https://pubmed.ncbi.nlm.nih.gov/17681768 DM8BKTV DI DM8BKTV DM8BKTV DN (10H-phenothiazin-10-yl)(o-tolyl)methanone DM8BKTV MI TTEB0GD DM8BKTV MN Cholinesterase (BCHE) DM8BKTV MT DTT DM8BKTV MA Inhibitor DM8BKTV RN Selective reversible inhibition of human butyrylcholinesterase by aryl amide derivatives of phenothiazine. Bioorg Med Chem. 2007 Oct 1;15(19):6367-78. DM8BKTV RU https://pubmed.ncbi.nlm.nih.gov/17681768 DMT3GAD DI DMT3GAD DMT3GAD DN (10H-phenothiazin-10-yl)(phenyl)methanone DMT3GAD MI TTEB0GD DMT3GAD MN Cholinesterase (BCHE) DMT3GAD MT DTT DMT3GAD MA Inhibitor DMT3GAD RN Selective reversible inhibition of human butyrylcholinesterase by aryl amide derivatives of phenothiazine. Bioorg Med Chem. 2007 Oct 1;15(19):6367-78. DMT3GAD RU https://pubmed.ncbi.nlm.nih.gov/17681768 DMRQ0ZF DI DMRQ0ZF DMRQ0ZF DN (10H-phenothiazin-10-yl)(p-tolyl)methanone DMRQ0ZF MI TTEB0GD DMRQ0ZF MN Cholinesterase (BCHE) DMRQ0ZF MT DTT DMRQ0ZF MA Inhibitor DMRQ0ZF RN Selective reversible inhibition of human butyrylcholinesterase by aryl amide derivatives of phenothiazine. Bioorg Med Chem. 2007 Oct 1;15(19):6367-78. DMRQ0ZF RU https://pubmed.ncbi.nlm.nih.gov/17681768 DMVTLF9 DI DMVTLF9 DMVTLF9 DN (10r)-10-Formyl-5,8,10-Trideazafolic Acid DMVTLF9 MI TTEXB9Z DMVTLF9 MN Glycinamide ribonucleotide formyltransferase (GART) DMVTLF9 MT DTT DMVTLF9 MA Inhibitor DMVTLF9 RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMVTLF9 RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMTPQ84 DI DMTPQ84 DMTPQ84 DN (11-BETA)-11,21-DIHYDROXY-PREGN-4-ENE-3,20-DIONE DMTPQ84 MI TTN7BL9 DMTPQ84 MN Corticosteroid 11-beta-dehydrogenase 1 (HSD11B1) DMTPQ84 MT DTT DMTPQ84 MA Inhibitor DMTPQ84 RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DMTPQ84 RU https://pubmed.ncbi.nlm.nih.gov/10592235 DMTPQ84 DI DMTPQ84 DMTPQ84 DN (11-BETA)-11,21-DIHYDROXY-PREGN-4-ENE-3,20-DIONE DMTPQ84 MI DE4LYSA DMTPQ84 MN Cytochrome P450 3A4 (CYP3A4) DMTPQ84 MT DME DMTPQ84 MA Metabolism DMTPQ84 RN Studies on pharmacokinetic drug interaction potential of vinpocetine. Medicines (Basel). 2015 Jun 5;2(2):93-105. DMTPQ84 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=28930203 DMTPQ84 DI DMTPQ84 DMTPQ84 DN (11-BETA)-11,21-DIHYDROXY-PREGN-4-ENE-3,20-DIONE DMTPQ84 MI TTOZRK6 DMTPQ84 MN Glucocorticoid receptor messenger RNA (GCR mRNA) DMTPQ84 MT DTT DMTPQ84 MA Agonist DMTPQ84 RN Functional probing of the human glucocorticoid receptor steroid-interacting surface by site-directed mutagenesis. Gln-642 plays an important role in steroid recognition and binding. J Biol Chem. 2000Jun 23;275(25):19041-9. DMTPQ84 RU https://pubmed.ncbi.nlm.nih.gov/10747884 DMTPQ84 DI DMTPQ84 DMTPQ84 DN (11-BETA)-11,21-DIHYDROXY-PREGN-4-ENE-3,20-DIONE DMTPQ84 MI TT26PHO DMTPQ84 MN Mineralocorticoid receptor (MR) DMTPQ84 MT DTT DMTPQ84 MA Inhibitor DMTPQ84 RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DMTPQ84 RU https://pubmed.ncbi.nlm.nih.gov/10592235 DMTPQ84 DI DMTPQ84 DMTPQ84 DN (11-BETA)-11,21-DIHYDROXY-PREGN-4-ENE-3,20-DIONE DMTPQ84 MI DTUGYRD DMTPQ84 MN P-glycoprotein 1 (ABCB1) DMTPQ84 MT DTP DMTPQ84 MA Substrate DMTPQ84 RN Antiestrogens and steroid hormones: substrates of the human P-glycoprotein. Biochem Pharmacol. 1994 Jul 19;48(2):287-92. DMTPQ84 RU http://www.ncbi.nlm.nih.gov/pubmed/7914405 DMZ5YMH DI DMZ5YMH DMZ5YMH DN (11E)-OCTADEC-11-ENOIC ACID DMZ5YMH MI TT2JWF6 DMZ5YMH MN Peroxisome proliferator-activated receptor delta (PPARD) DMZ5YMH MT DTT DMZ5YMH MA Inhibitor DMZ5YMH RN DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Nucleic Acids Res. 2011 Jan;39(Database issue):D1035-41. DMZ5YMH RU https://pubmed.ncbi.nlm.nih.gov/21059682 DMSUPVE DI DMSUPVE DMSUPVE DN (11H-Dibenzo[b,e][1,4]dioxepin-2-yl)-acetic acid DMSUPVE MI TT8NGED DMSUPVE MN Prostaglandin G/H synthase 1 (COX-1) DMSUPVE MT DTT DMSUPVE MA Inhibitor DMSUPVE RN Synthesis and antiinflammatory/analgesic activities of 11H-dibenzo[b, e,][1,4]dioxepinacetic acids. J Med Chem. 1986 Aug;29(8):1436-41. DMSUPVE RU https://pubmed.ncbi.nlm.nih.gov/3488405 DMSUPVE DI DMSUPVE DMSUPVE DN (11H-Dibenzo[b,e][1,4]dioxepin-2-yl)-acetic acid DMSUPVE MI TTVKILB DMSUPVE MN Prostaglandin G/H synthase 2 (COX-2) DMSUPVE MT DTT DMSUPVE MA Inhibitor DMSUPVE RN Synthesis and antiinflammatory/analgesic activities of 11H-dibenzo[b, e,][1,4]dioxepinacetic acids. J Med Chem. 1986 Aug;29(8):1436-41. DMSUPVE RU https://pubmed.ncbi.nlm.nih.gov/3488405 DM5ZTXL DI DM5ZTXL DM5ZTXL DN (11H-Dibenzo[b,e][1,4]dioxepin-7-yl)-acetic acid DM5ZTXL MI TT8NGED DM5ZTXL MN Prostaglandin G/H synthase 1 (COX-1) DM5ZTXL MT DTT DM5ZTXL MA Inhibitor DM5ZTXL RN Synthesis and antiinflammatory/analgesic activities of 11H-dibenzo[b, e,][1,4]dioxepinacetic acids. J Med Chem. 1986 Aug;29(8):1436-41. DM5ZTXL RU https://pubmed.ncbi.nlm.nih.gov/3488405 DM5ZTXL DI DM5ZTXL DM5ZTXL DN (11H-Dibenzo[b,e][1,4]dioxepin-7-yl)-acetic acid DM5ZTXL MI TTVKILB DM5ZTXL MN Prostaglandin G/H synthase 2 (COX-2) DM5ZTXL MT DTT DM5ZTXL MA Inhibitor DM5ZTXL RN Synthesis and antiinflammatory/analgesic activities of 11H-dibenzo[b, e,][1,4]dioxepinacetic acids. J Med Chem. 1986 Aug;29(8):1436-41. DM5ZTXL RU https://pubmed.ncbi.nlm.nih.gov/3488405 DMBY623 DI DMBY623 DMBY623 DN (11H-Dibenzo[b,e][1,4]dioxepin-8-yl)-acetic acid DMBY623 MI TT8NGED DMBY623 MN Prostaglandin G/H synthase 1 (COX-1) DMBY623 MT DTT DMBY623 MA Inhibitor DMBY623 RN Synthesis and antiinflammatory/analgesic activities of 11H-dibenzo[b, e,][1,4]dioxepinacetic acids. J Med Chem. 1986 Aug;29(8):1436-41. DMBY623 RU https://pubmed.ncbi.nlm.nih.gov/3488405 DMBY623 DI DMBY623 DMBY623 DN (11H-Dibenzo[b,e][1,4]dioxepin-8-yl)-acetic acid DMBY623 MI TTVKILB DMBY623 MN Prostaglandin G/H synthase 2 (COX-2) DMBY623 MT DTT DMBY623 MA Inhibitor DMBY623 RN Synthesis and antiinflammatory/analgesic activities of 11H-dibenzo[b, e,][1,4]dioxepinacetic acids. J Med Chem. 1986 Aug;29(8):1436-41. DMBY623 RU https://pubmed.ncbi.nlm.nih.gov/3488405 DMJNLQ5 DI DMJNLQ5 DMJNLQ5 DN (12E,20Z,18S)-8-hydroxyvariabilin DMJNLQ5 MI TTZ8EM9 DMJNLQ5 MN Glycine receptor (GlyR) DMJNLQ5 MT DTT DMJNLQ5 MA Inhibitor DMJNLQ5 RN Ircinialactams: subunit-selective glycine receptor modulators from Australian sponges of the family Irciniidae. Bioorg Med Chem. 2010 Apr 15;18(8):2912-9. DMJNLQ5 RU https://pubmed.ncbi.nlm.nih.gov/20346682 DMXD8H1 DI DMXD8H1 DMXD8H1 DN (1-Amino-2-phenyl-ethyl)-phosphinic acid DMXD8H1 MI TTPHMWB DMXD8H1 MN Aminopeptidase N (ANPEP) DMXD8H1 MT DTT DMXD8H1 MA Inhibitor DMXD8H1 RN Design of the first highly potent and selective aminopeptidase N (EC 3.4.11.2) inhibitor. Bioorg Med Chem Lett. 1999 Jun 7;9(11):1511-6. DMXD8H1 RU https://pubmed.ncbi.nlm.nih.gov/10386926 DMNUO79 DI DMNUO79 DMNUO79 DN (1-Amino-3-methyl-butyl)-phosphinic acid DMNUO79 MI TTPHMWB DMNUO79 MN Aminopeptidase N (ANPEP) DMNUO79 MT DTT DMNUO79 MA Inhibitor DMNUO79 RN Design of the first highly potent and selective aminopeptidase N (EC 3.4.11.2) inhibitor. Bioorg Med Chem Lett. 1999 Jun 7;9(11):1511-6. DMNUO79 RU https://pubmed.ncbi.nlm.nih.gov/10386926 DMJL8QZ DI DMJL8QZ DMJL8QZ DN (1-Amino-3-methylsulfanyl-propyl)-phosphinic acid DMJL8QZ MI TTPHMWB DMJL8QZ MN Aminopeptidase N (ANPEP) DMJL8QZ MT DTT DMJL8QZ MA Inhibitor DMJL8QZ RN Design of the first highly potent and selective aminopeptidase N (EC 3.4.11.2) inhibitor. Bioorg Med Chem Lett. 1999 Jun 7;9(11):1511-6. DMJL8QZ RU https://pubmed.ncbi.nlm.nih.gov/10386926 DMXD697 DI DMXD697 DMXD697 DN (1-Amino-3-phenyl-propyl)-phosphinic acid DMXD697 MI TTPHMWB DMXD697 MN Aminopeptidase N (ANPEP) DMXD697 MT DTT DMXD697 MA Inhibitor DMXD697 RN Design of the first highly potent and selective aminopeptidase N (EC 3.4.11.2) inhibitor. Bioorg Med Chem Lett. 1999 Jun 7;9(11):1511-6. DMXD697 RU https://pubmed.ncbi.nlm.nih.gov/10386926 DMUACZF DI DMUACZF DMUACZF DN (1-Amino-ethyl)-phosphinic acid DMUACZF MI TTPHMWB DMUACZF MN Aminopeptidase N (ANPEP) DMUACZF MT DTT DMUACZF MA Inhibitor DMUACZF RN Design of the first highly potent and selective aminopeptidase N (EC 3.4.11.2) inhibitor. Bioorg Med Chem Lett. 1999 Jun 7;9(11):1511-6. DMUACZF RU https://pubmed.ncbi.nlm.nih.gov/10386926 DMNIP7J DI DMNIP7J DMNIP7J DN (1-Benzyl-1H-indazol-5-yl)-quinazolin-4-yl-amine DMNIP7J MI TT6EO5L DMNIP7J MN Erbb2 tyrosine kinase receptor (HER2) DMNIP7J MT DTT DMNIP7J MA Inhibitor DMNIP7J RN Indazolylamino quinazolines and pyridopyrimidines as inhibitors of the EGFr and C-erbB-2. Bioorg Med Chem Lett. 2001 Jun 4;11(11):1401-5. DMNIP7J RU https://pubmed.ncbi.nlm.nih.gov/11378364 DM0SCW9 DI DM0SCW9 DM0SCW9 DN (1-Benzyl-1H-indol-5-yl)-quinazolin-4-yl-amine DM0SCW9 MI TTR5TV4 DM0SCW9 MN ERBB2 messenger RNA (HER2 mRNA) DM0SCW9 MT DTT DM0SCW9 MA Inhibitor DM0SCW9 RN Indazolylamino quinazolines and pyridopyrimidines as inhibitors of the EGFr and C-erbB-2. Bioorg Med Chem Lett. 2001 Jun 4;11(11):1401-5. DM0SCW9 RU https://pubmed.ncbi.nlm.nih.gov/11378364 DM0SCW9 DI DM0SCW9 DM0SCW9 DN (1-Benzyl-1H-indol-5-yl)-quinazolin-4-yl-amine DM0SCW9 MI TT6EO5L DM0SCW9 MN Erbb2 tyrosine kinase receptor (HER2) DM0SCW9 MT DTT DM0SCW9 MA Inhibitor DM0SCW9 RN Indazolylamino quinazolines and pyridopyrimidines as inhibitors of the EGFr and C-erbB-2. Bioorg Med Chem Lett. 2001 Jun 4;11(11):1401-5. DM0SCW9 RU https://pubmed.ncbi.nlm.nih.gov/11378364 DMWK3RO DI DMWK3RO DMWK3RO DN (1-Benzyl-2-oxo-ethyl)-carbamic acid benzyl ester DMWK3RO MI TTG5QB7 DMWK3RO MN Calpain-2 (CAPN2) DMWK3RO MT DTT DMWK3RO MA Inhibitor DMWK3RO RN Alpha-diketone and alpha-keto ester derivatives of N-protected amino acids and peptides as novel inhibitors of cysteine and serine proteinases. J Med Chem. 1990 Jan;33(1):11-3. DMWK3RO RU https://pubmed.ncbi.nlm.nih.gov/2296008 DMPKM9B DI DMPKM9B DMPKM9B DN (1H-Benzoimidazol-5-yl)-(1H-imidazol-2-yl)-amine DMPKM9B MI TTWG9A4 DMPKM9B MN Adrenergic receptor alpha-2A (ADRA2A) DMPKM9B MT DTT DMPKM9B MA Inhibitor DMPKM9B RN Synthesis and evaluation of 2-(arylamino)imidazoles as alpha 2-adrenergic agonists. J Med Chem. 1997 Jan 3;40(1):18-23. DMPKM9B RU https://pubmed.ncbi.nlm.nih.gov/9016324 DMPKM9B DI DMPKM9B DMPKM9B DN (1H-Benzoimidazol-5-yl)-(1H-imidazol-2-yl)-amine DMPKM9B MI TT2NUT5 DMPKM9B MN Adrenergic receptor alpha-2C (ADRA2C) DMPKM9B MT DTT DMPKM9B MA Inhibitor DMPKM9B RN Synthesis and evaluation of 2-(arylamino)imidazoles as alpha 2-adrenergic agonists. J Med Chem. 1997 Jan 3;40(1):18-23. DMPKM9B RU https://pubmed.ncbi.nlm.nih.gov/9016324 DM4FSTL DI DM4FSTL DM4FSTL DN (1H-Imidazo[4,5-c]quinolin-4-yl)-phenyl-amine HCl DM4FSTL MI TTK25J1 DM4FSTL MN Adenosine A1 receptor (ADORA1) DM4FSTL MT DTT DM4FSTL MA Inhibitor DM4FSTL RN 1H-imidazo[4,5-c]quinolin-4-amines: novel non-xanthine adenosine antagonists. J Med Chem. 1991 Mar;34(3):1202-6. DM4FSTL RU https://pubmed.ncbi.nlm.nih.gov/2002461 DM4FSTL DI DM4FSTL DM4FSTL DN (1H-Imidazo[4,5-c]quinolin-4-yl)-phenyl-amine HCl DM4FSTL MI TTM2AOE DM4FSTL MN Adenosine A2a receptor (ADORA2A) DM4FSTL MT DTT DM4FSTL MA Inhibitor DM4FSTL RN 1H-imidazo[4,5-c]quinolin-4-amines: novel non-xanthine adenosine antagonists. J Med Chem. 1991 Mar;34(3):1202-6. DM4FSTL RU https://pubmed.ncbi.nlm.nih.gov/2002461 DM4FSTL DI DM4FSTL DM4FSTL DN (1H-Imidazo[4,5-c]quinolin-4-yl)-phenyl-amine HCl DM4FSTL MI TTNE7KG DM4FSTL MN Adenosine A2b receptor (ADORA2B) DM4FSTL MT DTT DM4FSTL MA Inhibitor DM4FSTL RN 1H-imidazo[4,5-c]quinolin-4-amines: novel non-xanthine adenosine antagonists. J Med Chem. 1991 Mar;34(3):1202-6. DM4FSTL RU https://pubmed.ncbi.nlm.nih.gov/2002461 DMRDHL2 DI DMRDHL2 DMRDHL2 DN (1H-Imidazol-2-yl)-quinoxalin-6-yl-amine DMRDHL2 MI TTWG9A4 DMRDHL2 MN Adrenergic receptor alpha-2A (ADRA2A) DMRDHL2 MT DTT DMRDHL2 MA Inhibitor DMRDHL2 RN Synthesis and evaluation of 2-(arylamino)imidazoles as alpha 2-adrenergic agonists. J Med Chem. 1997 Jan 3;40(1):18-23. DMRDHL2 RU https://pubmed.ncbi.nlm.nih.gov/9016324 DMRDHL2 DI DMRDHL2 DMRDHL2 DN (1H-Imidazol-2-yl)-quinoxalin-6-yl-amine DMRDHL2 MI TT2NUT5 DMRDHL2 MN Adrenergic receptor alpha-2C (ADRA2C) DMRDHL2 MT DTT DMRDHL2 MA Inhibitor DMRDHL2 RN Synthesis and evaluation of 2-(arylamino)imidazoles as alpha 2-adrenergic agonists. J Med Chem. 1997 Jan 3;40(1):18-23. DMRDHL2 RU https://pubmed.ncbi.nlm.nih.gov/9016324 DM21CXZ DI DM21CXZ DM21CXZ DN (1H-indol-2-yl)(5-methoxy-1H-indol-2-yl)methanone DM21CXZ MI TTGJCWZ DM21CXZ MN Fms-like tyrosine kinase 3 (FLT-3) DM21CXZ MT DTT DM21CXZ MA Inhibitor DM21CXZ RN Novel bis(1H-indol-2-yl)methanones as potent inhibitors of FLT3 and platelet-derived growth factor receptor tyrosine kinase. J Med Chem. 2006 Jun 1;49(11):3101-15. DM21CXZ RU https://pubmed.ncbi.nlm.nih.gov/16722630 DM21CXZ DI DM21CXZ DM21CXZ DN (1H-indol-2-yl)(5-methoxy-1H-indol-2-yl)methanone DM21CXZ MI TT8FYO9 DM21CXZ MN Platelet-derived growth factor receptor alpha (PDGFRA) DM21CXZ MT DTT DM21CXZ MA Inhibitor DM21CXZ RN Novel bis(1H-indol-2-yl)methanones as potent inhibitors of FLT3 and platelet-derived growth factor receptor tyrosine kinase. J Med Chem. 2006 Jun 1;49(11):3101-15. DM21CXZ RU https://pubmed.ncbi.nlm.nih.gov/16722630 DM21CXZ DI DM21CXZ DM21CXZ DN (1H-indol-2-yl)(5-methoxy-1H-indol-2-yl)methanone DM21CXZ MI TTI7421 DM21CXZ MN Platelet-derived growth factor receptor beta (PDGFRB) DM21CXZ MT DTT DM21CXZ MA Inhibitor DM21CXZ RN Novel bis(1H-indol-2-yl)methanones as potent inhibitors of FLT3 and platelet-derived growth factor receptor tyrosine kinase. J Med Chem. 2006 Jun 1;49(11):3101-15. DM21CXZ RU https://pubmed.ncbi.nlm.nih.gov/16722630 DM94XJ2 DI DM94XJ2 DM94XJ2 DN (1H-indol-2-yl)(5-phenoxy-1H-indol-2-yl)methanone DM94XJ2 MI TTGJCWZ DM94XJ2 MN Fms-like tyrosine kinase 3 (FLT-3) DM94XJ2 MT DTT DM94XJ2 MA Inhibitor DM94XJ2 RN Novel bis(1H-indol-2-yl)methanones as potent inhibitors of FLT3 and platelet-derived growth factor receptor tyrosine kinase. J Med Chem. 2006 Jun 1;49(11):3101-15. DM94XJ2 RU https://pubmed.ncbi.nlm.nih.gov/16722630 DM94XJ2 DI DM94XJ2 DM94XJ2 DN (1H-indol-2-yl)(5-phenoxy-1H-indol-2-yl)methanone DM94XJ2 MI TT8FYO9 DM94XJ2 MN Platelet-derived growth factor receptor alpha (PDGFRA) DM94XJ2 MT DTT DM94XJ2 MA Inhibitor DM94XJ2 RN Novel bis(1H-indol-2-yl)methanones as potent inhibitors of FLT3 and platelet-derived growth factor receptor tyrosine kinase. J Med Chem. 2006 Jun 1;49(11):3101-15. DM94XJ2 RU https://pubmed.ncbi.nlm.nih.gov/16722630 DM94XJ2 DI DM94XJ2 DM94XJ2 DN (1H-indol-2-yl)(5-phenoxy-1H-indol-2-yl)methanone DM94XJ2 MI TTI7421 DM94XJ2 MN Platelet-derived growth factor receptor beta (PDGFRB) DM94XJ2 MT DTT DM94XJ2 MA Inhibitor DM94XJ2 RN Novel bis(1H-indol-2-yl)methanones as potent inhibitors of FLT3 and platelet-derived growth factor receptor tyrosine kinase. J Med Chem. 2006 Jun 1;49(11):3101-15. DM94XJ2 RU https://pubmed.ncbi.nlm.nih.gov/16722630 DM7KDNM DI DM7KDNM DM7KDNM DN (1H-indol-2-yl)(6-methoxy-1H-indol-2-yl)methanone DM7KDNM MI TTGJCWZ DM7KDNM MN Fms-like tyrosine kinase 3 (FLT-3) DM7KDNM MT DTT DM7KDNM MA Inhibitor DM7KDNM RN Novel bis(1H-indol-2-yl)methanones as potent inhibitors of FLT3 and platelet-derived growth factor receptor tyrosine kinase. J Med Chem. 2006 Jun 1;49(11):3101-15. DM7KDNM RU https://pubmed.ncbi.nlm.nih.gov/16722630 DM7KDNM DI DM7KDNM DM7KDNM DN (1H-indol-2-yl)(6-methoxy-1H-indol-2-yl)methanone DM7KDNM MI TT8FYO9 DM7KDNM MN Platelet-derived growth factor receptor alpha (PDGFRA) DM7KDNM MT DTT DM7KDNM MA Inhibitor DM7KDNM RN Novel bis(1H-indol-2-yl)methanones as potent inhibitors of FLT3 and platelet-derived growth factor receptor tyrosine kinase. J Med Chem. 2006 Jun 1;49(11):3101-15. DM7KDNM RU https://pubmed.ncbi.nlm.nih.gov/16722630 DM7KDNM DI DM7KDNM DM7KDNM DN (1H-indol-2-yl)(6-methoxy-1H-indol-2-yl)methanone DM7KDNM MI TTI7421 DM7KDNM MN Platelet-derived growth factor receptor beta (PDGFRB) DM7KDNM MT DTT DM7KDNM MA Inhibitor DM7KDNM RN Novel bis(1H-indol-2-yl)methanones as potent inhibitors of FLT3 and platelet-derived growth factor receptor tyrosine kinase. J Med Chem. 2006 Jun 1;49(11):3101-15. DM7KDNM RU https://pubmed.ncbi.nlm.nih.gov/16722630 DMW15DS DI DMW15DS DMW15DS DN (1H-indol-2-yl)(piperazin-1-yl)methanone DMW15DS MI TT9JNIC DMW15DS MN Histamine H3 receptor (H3R) DMW15DS MT DTT DMW15DS MA Inhibitor DMW15DS RN Preparation and biological evaluation of indole, benzimidazole, and thienopyrrole piperazine carboxamides: potent human histamine h(4) antagonists. J Med Chem. 2005 Dec 29;48(26):8289-98. DMW15DS RU https://pubmed.ncbi.nlm.nih.gov/16366610 DMW15DS DI DMW15DS DMW15DS DN (1H-indol-2-yl)(piperazin-1-yl)methanone DMW15DS MI TTXJ178 DMW15DS MN Histamine H4 receptor (H4R) DMW15DS MT DTT DMW15DS MA Inhibitor DMW15DS RN Preparation and biological evaluation of indole, benzimidazole, and thienopyrrole piperazine carboxamides: potent human histamine h(4) antagonists. J Med Chem. 2005 Dec 29;48(26):8289-98. DMW15DS RU https://pubmed.ncbi.nlm.nih.gov/16366610 DMHEYOK DI DMHEYOK DMHEYOK DN (1'H-Phenothiazin-1'-yl)(piperidin-1-yl)methanone DMHEYOK MI TTEB0GD DMHEYOK MN Cholinesterase (BCHE) DMHEYOK MT DTT DMHEYOK MA Inhibitor DMHEYOK RN Differential binding of phenothiazine urea derivatives to wild-type human cholinesterases and butyrylcholinesterase mutants. Bioorg Med Chem. 2010 Mar 15;18(6):2232-2244. DMHEYOK RU https://pubmed.ncbi.nlm.nih.gov/20181484 DMACN68 DI DMACN68 DMACN68 DN (1H-pyrazol-1-yl)(o-tolyl)methanone DMACN68 MI TTPLTSQ DMACN68 MN Neutrophil elastase (NE) DMACN68 MT DTT DMACN68 MA Inhibitor DMACN68 RN N-benzoylpyrazoles are novel small-molecule inhibitors of human neutrophil elastase. J Med Chem. 2007 Oct 4;50(20):4928-38. DMACN68 RU https://pubmed.ncbi.nlm.nih.gov/17850059 DM5L8WX DI DM5L8WX DM5L8WX DN (1-hydroxy-1-phosphono-heptyl)-phosphonic acid DM5L8WX MI TTIKWV4 DM5L8WX MN Geranyltranstransferase (FDPS) DM5L8WX MT DTT DM5L8WX MA Inhibitor DM5L8WX RN Synthesis and biological evaluation of 2-alkylaminoethyl-1,1-bisphosphonic acids against Trypanosoma cruzi and Toxoplasma gondii targeting farnesyl... Bioorg Med Chem. 2008 Mar 15;16(6):3283-90. DM5L8WX RU https://pubmed.ncbi.nlm.nih.gov/18096393 DMXY9R5 DI DMXY9R5 DMXY9R5 DN (1-Phenethyl-piperidin-4-yl)-phenyl-methanone DMXY9R5 MI TTJQOD7 DMXY9R5 MN 5-HT 2A receptor (HTR2A) DMXY9R5 MT DTT DMXY9R5 MA Inhibitor DMXY9R5 RN Current and novel approaches to the drug treatment of schizophrenia. J Med Chem. 2001 Feb 15;44(4):477-501. DMXY9R5 RU https://pubmed.ncbi.nlm.nih.gov/11170639 DM0TUKZ DI DM0TUKZ DM0TUKZ DN (1-phenylcyclopentyl)methanamine DM0TUKZ MI TTDIGC1 DM0TUKZ MN Dipeptidyl peptidase 4 (DPP-4) DM0TUKZ MT DTT DM0TUKZ MA Inhibitor DM0TUKZ RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DM0TUKZ RU https://pubmed.ncbi.nlm.nih.gov/10592235 DMECH9W DI DMECH9W DMECH9W DN (1-Phenyl-ethyl)-(2-phenyl-quinazolin-4-yl)-amine DMECH9W MI TTVBI8W DMECH9W MN Dopamine transporter (DAT) DMECH9W MT DTT DMECH9W MA Inhibitor DMECH9W RN Identification of a novel partial inhibitor of dopamine transporter among 4-substituted 2-phenylquinazolines. Bioorg Med Chem Lett. 2002 Aug 19;12(16):2225-8. DMECH9W RU https://pubmed.ncbi.nlm.nih.gov/12127543 DMZU2VG DI DMZU2VG DMZU2VG DN (1-Phenyl-propyl)-(9-phenyl-9H-purin-6-yl)-amine DMZU2VG MI TTK25J1 DMZU2VG MN Adenosine A1 receptor (ADORA1) DMZU2VG MT DTT DMZU2VG MA Inhibitor DMZU2VG RN N6,9-disubstituted adenines: potent, selective antagonists at the A1 adenosine receptor. J Med Chem. 1991 Sep;34(9):2877-82. DMZU2VG RU https://pubmed.ncbi.nlm.nih.gov/1895305 DMVE34H DI DMVE34H DMVE34H DN (1r)-1,2,2-trimethylpropyl (r)-methylphosphinate DMVE34H MI TTMF541 DMVE34H MN Liver carboxylesterase (CES1) DMVE34H MT DTT DMVE34H MA Inhibitor DMVE34H RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DMVE34H RU https://pubmed.ncbi.nlm.nih.gov/10592235 DMVE34H DI DMVE34H DMVE34H DN (1r)-1,2,2-trimethylpropyl (r)-methylphosphinate DMVE34H MI TTDNFMT DMVE34H MN Platelet-activating factor acetylhydrolase (PLA2G7) DMVE34H MT DTT DMVE34H MA Inhibitor DMVE34H RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DMVE34H RU https://pubmed.ncbi.nlm.nih.gov/10592235 DMCVKTB DI DMCVKTB DMCVKTB DN (1R)-1,2,2-TRIMETHYLPROPYL (S)-METHYLPHOSPHINATE DMCVKTB MI TT1RS9F DMCVKTB MN Acetylcholinesterase (AChE) DMCVKTB MT DTT DMCVKTB MA Inhibitor DMCVKTB RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DMCVKTB RU https://pubmed.ncbi.nlm.nih.gov/10592235 DMGAJYW DI DMGAJYW DMGAJYW DN (1R)-MENTHYL HEXYL PHOSPHONATE GROUP DMGAJYW MI TTEB0GD DMGAJYW MN Cholinesterase (BCHE) DMGAJYW MT DTT DMGAJYW MA Inhibitor DMGAJYW RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DMGAJYW RU https://pubmed.ncbi.nlm.nih.gov/10592235 DM18E9D DI DM18E9D DM18E9D DN (1R,2R)-1,2-diphenylethane-1,2-diamine DM18E9D MI TTDIGC1 DM18E9D MN Dipeptidyl peptidase 4 (DPP-4) DM18E9D MT DTT DM18E9D MA Inhibitor DM18E9D RN In silico fragment-based discovery of DPP-IV S1 pocket binders. Bioorg Med Chem Lett. 2006 Mar 1;16(5):1405-9. DM18E9D RU https://pubmed.ncbi.nlm.nih.gov/16321524 DM5ROS1 DI DM5ROS1 DM5ROS1 DN (1R,2R)-2-(1H-Imidazol-4-yl)-1-methyl-propylamine DM5ROS1 MI TT9JNIC DM5ROS1 MN Histamine H3 receptor (H3R) DM5ROS1 MT DTT DM5ROS1 MA Inhibitor DM5ROS1 RN A novel pyrrolidine analog of histamine as a potent, highly selective histamine H3 receptor agonist. J Med Chem. 1995 May 12;38(10):1593-9. DM5ROS1 RU https://pubmed.ncbi.nlm.nih.gov/7752184 DMYLPV1 DI DMYLPV1 DMYLPV1 DN (1R,2R)-N-Arachidonoylcyclopropanolamide DMYLPV1 MI TT6OEDT DMYLPV1 MN Cannabinoid receptor 1 (CB1) DMYLPV1 MT DTT DMYLPV1 MA Inhibitor DMYLPV1 RN Conformationally constrained fatty acid ethanolamides as cannabinoid and vanilloid receptor probes. J Med Chem. 2009 May 14;52(9):3001-9. DMYLPV1 RU https://pubmed.ncbi.nlm.nih.gov/19361197 DMYLPV1 DI DMYLPV1 DMYLPV1 DN (1R,2R)-N-Arachidonoylcyclopropanolamide DMYLPV1 MI TTMSFAW DMYLPV1 MN Cannabinoid receptor 2 (CB2) DMYLPV1 MT DTT DMYLPV1 MA Inhibitor DMYLPV1 RN Conformationally constrained fatty acid ethanolamides as cannabinoid and vanilloid receptor probes. J Med Chem. 2009 May 14;52(9):3001-9. DMYLPV1 RU https://pubmed.ncbi.nlm.nih.gov/19361197 DM28D9E DI DM28D9E DM28D9E DN (1R,2S)-1,2-diphenylethane-1,2-diamine DM28D9E MI TTDIGC1 DM28D9E MN Dipeptidyl peptidase 4 (DPP-4) DM28D9E MT DTT DM28D9E MA Inhibitor DM28D9E RN In silico fragment-based discovery of DPP-IV S1 pocket binders. Bioorg Med Chem Lett. 2006 Mar 1;16(5):1405-9. DM28D9E RU https://pubmed.ncbi.nlm.nih.gov/16321524 DMZ3DMX DI DMZ3DMX DMZ3DMX DN (1R,2S)-2-(1H-Imidazol-4-yl)-1-methyl-propylamine DMZ3DMX MI TT9JNIC DMZ3DMX MN Histamine H3 receptor (H3R) DMZ3DMX MT DTT DMZ3DMX MA Inhibitor DMZ3DMX RN A novel pyrrolidine analog of histamine as a potent, highly selective histamine H3 receptor agonist. J Med Chem. 1995 May 12;38(10):1593-9. DMZ3DMX RU https://pubmed.ncbi.nlm.nih.gov/7752184 DM39AFU DI DM39AFU DM39AFU DN (1R,2S)-N-Arachidonoylcyclopropanolamide DM39AFU MI TT6OEDT DM39AFU MN Cannabinoid receptor 1 (CB1) DM39AFU MT DTT DM39AFU MA Inhibitor DM39AFU RN Conformationally constrained fatty acid ethanolamides as cannabinoid and vanilloid receptor probes. J Med Chem. 2009 May 14;52(9):3001-9. DM39AFU RU https://pubmed.ncbi.nlm.nih.gov/19361197 DM39AFU DI DM39AFU DM39AFU DN (1R,2S)-N-Arachidonoylcyclopropanolamide DM39AFU MI TTMSFAW DM39AFU MN Cannabinoid receptor 2 (CB2) DM39AFU MT DTT DM39AFU MA Inhibitor DM39AFU RN Conformationally constrained fatty acid ethanolamides as cannabinoid and vanilloid receptor probes. J Med Chem. 2009 May 14;52(9):3001-9. DM39AFU RU https://pubmed.ncbi.nlm.nih.gov/19361197 DMITW5P DI DMITW5P DMITW5P DN (1R,2S)-N-Oleoylcyclopropanolamide DMITW5P MI TT6OEDT DMITW5P MN Cannabinoid receptor 1 (CB1) DMITW5P MT DTT DMITW5P MA Inhibitor DMITW5P RN Conformationally constrained fatty acid ethanolamides as cannabinoid and vanilloid receptor probes. J Med Chem. 2009 May 14;52(9):3001-9. DMITW5P RU https://pubmed.ncbi.nlm.nih.gov/19361197 DMITW5P DI DMITW5P DMITW5P DN (1R,2S)-N-Oleoylcyclopropanolamide DMITW5P MI TTMSFAW DMITW5P MN Cannabinoid receptor 2 (CB2) DMITW5P MT DTT DMITW5P MA Inhibitor DMITW5P RN Conformationally constrained fatty acid ethanolamides as cannabinoid and vanilloid receptor probes. J Med Chem. 2009 May 14;52(9):3001-9. DMITW5P RU https://pubmed.ncbi.nlm.nih.gov/19361197 DMUJ7ZE DI DMUJ7ZE DMUJ7ZE DN (1R,5R)-30-OXO-19-OXA-2,6,10,12-TETRAAZAHEXACYCLO[18.6.2.1^{2,5}.1^{14,18}.0^{8,12}.0^{23,27}]TRIACONTA-8,10,14(29),15,17,20(28),21,23(27)-OCTAENE-17-CARBONITRILE (STRUCTURAL MIX) DMUJ7ZE MI TTQ6VDM DMUJ7ZE MN Voltage-gated potassium channel Kv11.1 (KCNH2) DMUJ7ZE MT DTT DMUJ7ZE MA Inhibitor DMUJ7ZE RN Side chain flexibilities in the human ether-a-go-go related gene potassium channel (hERG) together with matched-pair binding studies suggest a new ... J Med Chem. 2009 Jul 23;52(14):4266-76. DMUJ7ZE RU https://pubmed.ncbi.nlm.nih.gov/19534531 DMJ2WD5 DI DMJ2WD5 DMJ2WD5 DN (1S)-MENTHYL HEXYL PHOSPHONATE GROUP DMJ2WD5 MI TTEB0GD DMJ2WD5 MN Cholinesterase (BCHE) DMJ2WD5 MT DTT DMJ2WD5 MA Inhibitor DMJ2WD5 RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DMJ2WD5 RU https://pubmed.ncbi.nlm.nih.gov/10592235 DMZCS2K DI DMZCS2K DMZCS2K DN (1S,2S)-2-(1H-Imidazol-4-yl)-cyclopentylamine DMZCS2K MI TT9JNIC DMZCS2K MN Histamine H3 receptor (H3R) DMZCS2K MT DTT DMZCS2K MA Inhibitor DMZCS2K RN A novel pyrrolidine analog of histamine as a potent, highly selective histamine H3 receptor agonist. J Med Chem. 1995 May 12;38(10):1593-9. DMZCS2K RU https://pubmed.ncbi.nlm.nih.gov/7752184 DMKA0ON DI DMKA0ON DMKA0ON DN (1S,2S)-N-Arachidonoylcyclopropanolamide DMKA0ON MI TT6OEDT DMKA0ON MN Cannabinoid receptor 1 (CB1) DMKA0ON MT DTT DMKA0ON MA Inhibitor DMKA0ON RN Conformationally constrained fatty acid ethanolamides as cannabinoid and vanilloid receptor probes. J Med Chem. 2009 May 14;52(9):3001-9. DMKA0ON RU https://pubmed.ncbi.nlm.nih.gov/19361197 DMKA0ON DI DMKA0ON DMKA0ON DN (1S,2S)-N-Arachidonoylcyclopropanolamide DMKA0ON MI TTMSFAW DMKA0ON MN Cannabinoid receptor 2 (CB2) DMKA0ON MT DTT DMKA0ON MA Inhibitor DMKA0ON RN Conformationally constrained fatty acid ethanolamides as cannabinoid and vanilloid receptor probes. J Med Chem. 2009 May 14;52(9):3001-9. DMKA0ON RU https://pubmed.ncbi.nlm.nih.gov/19361197 DMIV2OY DI DMIV2OY DMIV2OY DN (1S,2S)-N-Oleoylcyclopropanolamide DMIV2OY MI TT6OEDT DMIV2OY MN Cannabinoid receptor 1 (CB1) DMIV2OY MT DTT DMIV2OY MA Inhibitor DMIV2OY RN Conformationally constrained fatty acid ethanolamides as cannabinoid and vanilloid receptor probes. J Med Chem. 2009 May 14;52(9):3001-9. DMIV2OY RU https://pubmed.ncbi.nlm.nih.gov/19361197 DMIV2OY DI DMIV2OY DMIV2OY DN (1S,2S)-N-Oleoylcyclopropanolamide DMIV2OY MI TTMSFAW DMIV2OY MN Cannabinoid receptor 2 (CB2) DMIV2OY MT DTT DMIV2OY MA Inhibitor DMIV2OY RN Conformationally constrained fatty acid ethanolamides as cannabinoid and vanilloid receptor probes. J Med Chem. 2009 May 14;52(9):3001-9. DMIV2OY RU https://pubmed.ncbi.nlm.nih.gov/19361197 DM5DOAF DI DM5DOAF DM5DOAF DN (1S,3R)-ACPD DM5DOAF MI TTVBPDM DM5DOAF MN Metabotropic glutamate receptor 1 (mGluR1) DM5DOAF MT DTT DM5DOAF MA Agonist DM5DOAF RN Characterization of [(3)H]Quisqualate binding to recombinant rat metabotropic glutamate 1a and 5a receptors and to rat and human brain sections. J Neurochem. 2000 Dec;75(6):2590-601. DM5DOAF RU https://pubmed.ncbi.nlm.nih.gov/11080213 DM5DOAF DI DM5DOAF DM5DOAF DN (1S,3R)-ACPD DM5DOAF MI TTXJ47W DM5DOAF MN Metabotropic glutamate receptor 2 (mGluR2) DM5DOAF MT DTT DM5DOAF MA Agonist DM5DOAF RN [3H]-LY341495 as a novel antagonist radioligand for group II metabotropic glutamate (mGlu) receptors: characterization of binding to membranes of mGlu receptor subtype expressing cells. Neuropharmacology. 1999 Oct;38(10):1519-29. DM5DOAF RU https://pubmed.ncbi.nlm.nih.gov/10530814 DM5DOAF DI DM5DOAF DM5DOAF DN (1S,3R)-ACPD DM5DOAF MI TT8A9EF DM5DOAF MN Metabotropic glutamate receptor 3 (mGluR3) DM5DOAF MT DTT DM5DOAF MA Agonist DM5DOAF RN [3H]-LY341495 as a novel antagonist radioligand for group II metabotropic glutamate (mGlu) receptors: characterization of binding to membranes of mGlu receptor subtype expressing cells. Neuropharmacology. 1999 Oct;38(10):1519-29. DM5DOAF RU https://pubmed.ncbi.nlm.nih.gov/10530814 DM5DOAF DI DM5DOAF DM5DOAF DN (1S,3R)-ACPD DM5DOAF MI TTHS256 DM5DOAF MN Metabotropic glutamate receptor 5 (mGluR5) DM5DOAF MT DTT DM5DOAF MA Agonist DM5DOAF RN Characterization of [(3)H]Quisqualate binding to recombinant rat metabotropic glutamate 1a and 5a receptors and to rat and human brain sections. J Neurochem. 2000 Dec;75(6):2590-601. DM5DOAF RU https://pubmed.ncbi.nlm.nih.gov/11080213 DM5DOAF DI DM5DOAF DM5DOAF DN (1S,3R)-ACPD DM5DOAF MI TTWRP2F DM5DOAF MN Metabotropic glutamate receptor 6 (mGluR6) DM5DOAF MT DTT DM5DOAF MA Agonist DM5DOAF RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 294). DM5DOAF RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=294 DM5DOAF DI DM5DOAF DM5DOAF DN (1S,3R)-ACPD DM5DOAF MI TT0I76D DM5DOAF MN Metabotropic glutamate receptor 7 (mGluR7) DM5DOAF MT DTT DM5DOAF MA Agonist DM5DOAF RN Binding of [3H](2S,1'S,2'S)-2-(9-xanthylmethyl)-2-(2'-carboxycyclopropyl) glycine ([3H]LY341495) to cell membranes expressing recombinant human group III metabotropic glutamate receptor subtypes. Naunyn Schmiedebergs Arch Pharmacol. 2000 Dec;362(6):546-54. DM5DOAF RU https://pubmed.ncbi.nlm.nih.gov/11138847 DM5DOAF DI DM5DOAF DM5DOAF DN (1S,3R)-ACPD DM5DOAF MI TT0IFKL DM5DOAF MN Metabotropic glutamate receptor 8 (mGluR8) DM5DOAF MT DTT DM5DOAF MA Agonist DM5DOAF RN Group III human metabotropic glutamate receptors 4, 7 and 8: molecular cloning, functional expression, and comparison of pharmacological properties in RGT cells. Brain Res Mol Brain Res. 1998 Jan;53(1-2):88-97. DM5DOAF RU https://pubmed.ncbi.nlm.nih.gov/9473604 DMYOTMP DI DMYOTMP DMYOTMP DN (2-(2-chlorophenyl)pyridin-3-yl)methanamine DMYOTMP MI TTDIGC1 DMYOTMP MN Dipeptidyl peptidase 4 (DPP-4) DMYOTMP MT DTT DMYOTMP MA Inhibitor DMYOTMP RN In silico fragment-based discovery of DPP-IV S1 pocket binders. Bioorg Med Chem Lett. 2006 Mar 1;16(5):1405-9. DMYOTMP RU https://pubmed.ncbi.nlm.nih.gov/16321524 DMA15WU DI DMA15WU DMA15WU DN (2-(4-chlorobenzyloxy)-5-bromophenyl)methanamine DMA15WU MI TT2CEJG DMA15WU MN C-C chemokine receptor type 5 (CCR5) DMA15WU MT DTT DMA15WU MA Inhibitor DMA15WU RN CCR5 receptor antagonists: discovery and SAR of novel 4-hydroxypiperidine derivatives. Bioorg Med Chem Lett. 2007 Apr 1;17(7):1883-7. DMA15WU RU https://pubmed.ncbi.nlm.nih.gov/17314043 DM2ATRC DI DM2ATRC DM2ATRC DN (2,2-dimethyl-1,3-dioxolan-4-yl)methyl sulfamate DM2ATRC MI TTANPDJ DM2ATRC MN Carbonic anhydrase II (CA-II) DM2ATRC MT DTT DM2ATRC MA Inhibitor DM2ATRC RN Inhibition of carbonic anhydrase-II by sulfamate and sulfamide groups: an investigation involving direct thermodynamic binding measurements. J Med Chem. 2006 Jun 15;49(12):3496-500. DM2ATRC RU https://pubmed.ncbi.nlm.nih.gov/16759092 DMNGEFS DI DMNGEFS DMNGEFS DN (2,4-dihydroindeno[1,2-c]pyrazol-3-yl)phenylamine DMNGEFS MI TTI7421 DMNGEFS MN Platelet-derived growth factor receptor beta (PDGFRB) DMNGEFS MT DTT DMNGEFS MA Inhibitor DMNGEFS RN (6,7-Dimethoxy-2,4-dihydroindeno[1,2-c]pyrazol-3-yl)phenylamines: platelet-derived growth factor receptor tyrosine kinase inhibitors with broad ant... J Med Chem. 2005 Dec 29;48(26):8163-73. DMNGEFS RU https://pubmed.ncbi.nlm.nih.gov/16366598 DM97GFB DI DM97GFB DM97GFB DN (2,5-Diphenyl-furan-3-yl)-phenyl-methanone DM97GFB MI TTZ97H5 DM97GFB MN Phosphodiesterase 4A (PDE4A) DM97GFB MT DTT DM97GFB MA Inhibitor DM97GFB RN Substituted furans as inhibitors of the PDE4 enzyme. Bioorg Med Chem Lett. 1999 Feb 8;9(3):323-6. DM97GFB RU https://pubmed.ncbi.nlm.nih.gov/10091677 DMWRCM1 DI DMWRCM1 DMWRCM1 DN (2,6-Diamino-pyridin-3-yl)-phenyl-methanone DMWRCM1 MI TTH6V3D DMWRCM1 MN Cyclin-dependent kinase 1 (CDK1) DMWRCM1 MT DTT DMWRCM1 MA Inhibitor DMWRCM1 RN 3-Acyl-2,6-diaminopyridines as cyclin-dependent kinase inhibitors: synthesis and biological evaluation. Bioorg Med Chem Lett. 2005 May 2;15(9):2221-4. DMWRCM1 RU https://pubmed.ncbi.nlm.nih.gov/15837297 DM27TH9 DI DM27TH9 DM27TH9 DN (2,6-Dichloro-phenyl)-(1H-imidazol-2-yl)-amine DM27TH9 MI TTNGILX DM27TH9 MN Adrenergic receptor alpha-1A (ADRA1A) DM27TH9 MT DTT DM27TH9 MA Inhibitor DM27TH9 RN Synthesis and evaluation of 2-(arylamino)imidazoles as alpha 2-adrenergic agonists. J Med Chem. 1997 Jan 3;40(1):18-23. DM27TH9 RU https://pubmed.ncbi.nlm.nih.gov/9016324 DM27TH9 DI DM27TH9 DM27TH9 DN (2,6-Dichloro-phenyl)-(1H-imidazol-2-yl)-amine DM27TH9 MI TTBRKXS DM27TH9 MN Adrenergic receptor alpha-1B (ADRA1B) DM27TH9 MT DTT DM27TH9 MA Inhibitor DM27TH9 RN Synthesis and evaluation of 2-(arylamino)imidazoles as alpha 2-adrenergic agonists. J Med Chem. 1997 Jan 3;40(1):18-23. DM27TH9 RU https://pubmed.ncbi.nlm.nih.gov/9016324 DM27TH9 DI DM27TH9 DM27TH9 DN (2,6-Dichloro-phenyl)-(1H-imidazol-2-yl)-amine DM27TH9 MI TT34BHT DM27TH9 MN Adrenergic receptor alpha-1D (ADRA1D) DM27TH9 MT DTT DM27TH9 MA Inhibitor DM27TH9 RN Synthesis and evaluation of 2-(arylamino)imidazoles as alpha 2-adrenergic agonists. J Med Chem. 1997 Jan 3;40(1):18-23. DM27TH9 RU https://pubmed.ncbi.nlm.nih.gov/9016324 DM27TH9 DI DM27TH9 DM27TH9 DN (2,6-Dichloro-phenyl)-(1H-imidazol-2-yl)-amine DM27TH9 MI TTWG9A4 DM27TH9 MN Adrenergic receptor alpha-2A (ADRA2A) DM27TH9 MT DTT DM27TH9 MA Inhibitor DM27TH9 RN Synthesis and evaluation of 2-(arylamino)imidazoles as alpha 2-adrenergic agonists. J Med Chem. 1997 Jan 3;40(1):18-23. DM27TH9 RU https://pubmed.ncbi.nlm.nih.gov/9016324 DM27TH9 DI DM27TH9 DM27TH9 DN (2,6-Dichloro-phenyl)-(1H-imidazol-2-yl)-amine DM27TH9 MI TT2NUT5 DM27TH9 MN Adrenergic receptor alpha-2C (ADRA2C) DM27TH9 MT DTT DM27TH9 MA Inhibitor DM27TH9 RN Synthesis and evaluation of 2-(arylamino)imidazoles as alpha 2-adrenergic agonists. J Med Chem. 1997 Jan 3;40(1):18-23. DM27TH9 RU https://pubmed.ncbi.nlm.nih.gov/9016324 DM1RYH9 DI DM1RYH9 DM1RYH9 DN (24E)-3beta-hydroxy-7,24-euphadien-26-oic acid DM1RYH9 MI TTIU7X1 DM1RYH9 MN Herpes simplex virus DNA polymerase UL30 (HSV UL30) DM1RYH9 MT DTT DM1RYH9 MA Inhibitor DM1RYH9 RN A new 7,8-euphadien-type triterpenoid from Brackenridgea nitida and Bleasdalea bleasdalei that inhibits DNA polymerase beta. J Nat Prod. 2000 Oct;63(10):1356-60. DM1RYH9 RU https://pubmed.ncbi.nlm.nih.gov/11076551 DMPL80G DI DMPL80G DMPL80G DN (24S)-ethylcholesta-7,9(11),22(E)-triene-3b-ol DMPL80G MI TT1RS9F DMPL80G MN Acetylcholinesterase (AChE) DMPL80G MT DTT DMPL80G MA Inhibitor DMPL80G RN Isolation and cholinesterase-inhibition studies of sterols from Haloxylon recurvum. Bioorg Med Chem Lett. 2006 Feb;16(3):573-80. DMPL80G RU https://pubmed.ncbi.nlm.nih.gov/16274989 DMPL80G DI DMPL80G DMPL80G DN (24S)-ethylcholesta-7,9(11),22(E)-triene-3b-ol DMPL80G MI TTEB0GD DMPL80G MN Cholinesterase (BCHE) DMPL80G MT DTT DMPL80G MA Inhibitor DMPL80G RN Isolation and cholinesterase-inhibition studies of sterols from Haloxylon recurvum. Bioorg Med Chem Lett. 2006 Feb;16(3):573-80. DMPL80G RU https://pubmed.ncbi.nlm.nih.gov/16274989 DMLEZKJ DI DMLEZKJ DMLEZKJ DN (2-Amino-4,5-dihydro-thiazol-4-yl)-acetic acid DMLEZKJ MI TT1MPAY DMLEZKJ MN GABA(A) receptor alpha-1 (GABRA1) DMLEZKJ MT DTT DMLEZKJ MA Inhibitor DMLEZKJ RN ( )-2-amino-2-thiazoline-4-ethanoic acid; a novel, specific GABAA receptor agonist. Bioorg. Med. Chem. Lett. 1(5):247-248 (1991). DMLEZKJ RU http://www.sciencedirect.com/science/article/pii/S0960894X01810350 DMLEZKJ DI DMLEZKJ DMLEZKJ DN (2-Amino-4,5-dihydro-thiazol-4-yl)-acetic acid DMLEZKJ MI TTNJYV2 DMLEZKJ MN Gamma-aminobutyric acid receptor (GAR) DMLEZKJ MT DTT DMLEZKJ MA Inhibitor DMLEZKJ RN ( )-2-amino-2-thiazoline-4-ethanoic acid; a novel, specific GABAA receptor agonist. Bioorg. Med. Chem. Lett. 1(5):247-248 (1991). DMLEZKJ RU http://www.sciencedirect.com/science/article/pii/S0960894X01810350 DMFRPGX DI DMFRPGX DMFRPGX DN (2-Benzyl-phenyl)-(2-pyrrolidin-1-yl-ethyl)-amine DMFRPGX MI TT4C8EA DMFRPGX MN Dopamine D3 receptor (D3R) DMFRPGX MT DTT DMFRPGX MA Inhibitor DMFRPGX RN Dopamine/serotonin receptor ligands. 9. Oxygen-containing midsized heterocyclic ring systems and nonrigidized analogues. A step toward dopamine D5 ... J Med Chem. 2004 Aug 12;47(17):4155-8. DMFRPGX RU https://pubmed.ncbi.nlm.nih.gov/15293986 DMTW0GD DI DMTW0GD DMTW0GD DN (2-biphenyl-3-yl-ethyl)-dimethyl-amine DMTW0GD MI TTO9X1H DMTW0GD MN 5-HT 7 receptor (HTR7) DMTW0GD MT DTT DMTW0GD MA Inhibitor DMTW0GD RN Novel aminoethylbiphenyls as 5-HT7 receptor ligands. Bioorg Med Chem Lett. 2007 Jun 1;17(11):3018-22. DMTW0GD RU https://pubmed.ncbi.nlm.nih.gov/17419056 DMZSP7F DI DMZSP7F DMZSP7F DN (2-BROMOETHYL)(2-'FORMYL-4'-AMINOPHENYL) ACETATE DMZSP7F MI TT3NKIB DMZSP7F MN Pancreatic elastase 1 (CELA1) DMZSP7F MT DTT DMZSP7F MA Inhibitor DMZSP7F RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DMZSP7F RU https://pubmed.ncbi.nlm.nih.gov/10592235 DM8N79M DI DM8N79M DM8N79M DN (2-Bromo-phenyl)-(1H-imidazol-2-yl)-amine DM8N79M MI TTNGILX DM8N79M MN Adrenergic receptor alpha-1A (ADRA1A) DM8N79M MT DTT DM8N79M MA Inhibitor DM8N79M RN Synthesis and evaluation of 2-(arylamino)imidazoles as alpha 2-adrenergic agonists. J Med Chem. 1997 Jan 3;40(1):18-23. DM8N79M RU https://pubmed.ncbi.nlm.nih.gov/9016324 DM8N79M DI DM8N79M DM8N79M DN (2-Bromo-phenyl)-(1H-imidazol-2-yl)-amine DM8N79M MI TTBRKXS DM8N79M MN Adrenergic receptor alpha-1B (ADRA1B) DM8N79M MT DTT DM8N79M MA Inhibitor DM8N79M RN Synthesis and evaluation of 2-(arylamino)imidazoles as alpha 2-adrenergic agonists. J Med Chem. 1997 Jan 3;40(1):18-23. DM8N79M RU https://pubmed.ncbi.nlm.nih.gov/9016324 DM8N79M DI DM8N79M DM8N79M DN (2-Bromo-phenyl)-(1H-imidazol-2-yl)-amine DM8N79M MI TT34BHT DM8N79M MN Adrenergic receptor alpha-1D (ADRA1D) DM8N79M MT DTT DM8N79M MA Inhibitor DM8N79M RN Synthesis and evaluation of 2-(arylamino)imidazoles as alpha 2-adrenergic agonists. J Med Chem. 1997 Jan 3;40(1):18-23. DM8N79M RU https://pubmed.ncbi.nlm.nih.gov/9016324 DM8N79M DI DM8N79M DM8N79M DN (2-Bromo-phenyl)-(1H-imidazol-2-yl)-amine DM8N79M MI TTWG9A4 DM8N79M MN Adrenergic receptor alpha-2A (ADRA2A) DM8N79M MT DTT DM8N79M MA Inhibitor DM8N79M RN Synthesis and evaluation of 2-(arylamino)imidazoles as alpha 2-adrenergic agonists. J Med Chem. 1997 Jan 3;40(1):18-23. DM8N79M RU https://pubmed.ncbi.nlm.nih.gov/9016324 DM8N79M DI DM8N79M DM8N79M DN (2-Bromo-phenyl)-(1H-imidazol-2-yl)-amine DM8N79M MI TT2NUT5 DM8N79M MN Adrenergic receptor alpha-2C (ADRA2C) DM8N79M MT DTT DM8N79M MA Inhibitor DM8N79M RN Synthesis and evaluation of 2-(arylamino)imidazoles as alpha 2-adrenergic agonists. J Med Chem. 1997 Jan 3;40(1):18-23. DM8N79M RU https://pubmed.ncbi.nlm.nih.gov/9016324 DMFX9H8 DI DMFX9H8 DMFX9H8 DN (2-bromophenyl)difluoromethanesulfonamide DMFX9H8 MI TTUNARX DMFX9H8 MN Carbonic anhydrase (CA) DMFX9H8 MT DTT DMFX9H8 MA Inhibitor DMFX9H8 RN Carbonic anhydrase inhibitors: inhibition of the human isozymes I, II, VA, and IX with a library of substituted difluoromethanesulfonamides. Bioorg Med Chem Lett. 2005 Dec 1;15(23):5192-6. DMFX9H8 RU https://pubmed.ncbi.nlm.nih.gov/16203142 DMFX9H8 DI DMFX9H8 DMFX9H8 DN (2-bromophenyl)difluoromethanesulfonamide DMFX9H8 MI TTHQPL7 DMFX9H8 MN Carbonic anhydrase I (CA-I) DMFX9H8 MT DTT DMFX9H8 MA Inhibitor DMFX9H8 RN Carbonic anhydrase inhibitors: inhibition of the human isozymes I, II, VA, and IX with a library of substituted difluoromethanesulfonamides. Bioorg Med Chem Lett. 2005 Dec 1;15(23):5192-6. DMFX9H8 RU https://pubmed.ncbi.nlm.nih.gov/16203142 DMFX9H8 DI DMFX9H8 DMFX9H8 DN (2-bromophenyl)difluoromethanesulfonamide DMFX9H8 MI TTANPDJ DMFX9H8 MN Carbonic anhydrase II (CA-II) DMFX9H8 MT DTT DMFX9H8 MA Inhibitor DMFX9H8 RN Carbonic anhydrase inhibitors: inhibition of the human isozymes I, II, VA, and IX with a library of substituted difluoromethanesulfonamides. Bioorg Med Chem Lett. 2005 Dec 1;15(23):5192-6. DMFX9H8 RU https://pubmed.ncbi.nlm.nih.gov/16203142 DMFX9H8 DI DMFX9H8 DMFX9H8 DN (2-bromophenyl)difluoromethanesulfonamide DMFX9H8 MI TT2LVK8 DMFX9H8 MN Carbonic anhydrase IX (CA-IX) DMFX9H8 MT DTT DMFX9H8 MA Inhibitor DMFX9H8 RN Carbonic anhydrase inhibitors: inhibition of the human isozymes I, II, VA, and IX with a library of substituted difluoromethanesulfonamides. Bioorg Med Chem Lett. 2005 Dec 1;15(23):5192-6. DMFX9H8 RU https://pubmed.ncbi.nlm.nih.gov/16203142 DMLTMPC DI DMLTMPC DMLTMPC DN (2-Butyryloxy-ethyl)-trimethyl-ammonium iodide DMLTMPC MI TT1RS9F DMLTMPC MN Acetylcholinesterase (AChE) DMLTMPC MT DTT DMLTMPC MA Inhibitor DMLTMPC RN Structure-based alignment and comparative molecular field analysis of acetylcholinesterase inhibitors. J Med Chem. 1996 Dec 20;39(26):5064-71. DMLTMPC RU https://pubmed.ncbi.nlm.nih.gov/8978837 DMOS864 DI DMOS864 DMOS864 DN (2-chloro-6-phenoxyphenyl)methanamine DMOS864 MI TTDIGC1 DMOS864 MN Dipeptidyl peptidase 4 (DPP-4) DMOS864 MT DTT DMOS864 MA Inhibitor DMOS864 RN In silico fragment-based discovery of DPP-IV S1 pocket binders. Bioorg Med Chem Lett. 2006 Mar 1;16(5):1405-9. DMOS864 RU https://pubmed.ncbi.nlm.nih.gov/16321524 DMCE1SU DI DMCE1SU DMCE1SU DN (2-Chloro-9-methyl-9H-purin-6-yl)-phenyl-amine DMCE1SU MI TTK25J1 DMCE1SU MN Adenosine A1 receptor (ADORA1) DMCE1SU MT DTT DMCE1SU MA Inhibitor DMCE1SU RN N6,9-disubstituted adenines: potent, selective antagonists at the A1 adenosine receptor. J Med Chem. 1991 Sep;34(9):2877-82. DMCE1SU RU https://pubmed.ncbi.nlm.nih.gov/1895305 DM6DH15 DI DM6DH15 DM6DH15 DN (2-Chloro-ethyl)-trimethyl-ammonium chloride DM6DH15 MI TT1RS9F DM6DH15 MN Acetylcholinesterase (AChE) DM6DH15 MT DTT DM6DH15 MA Inhibitor DM6DH15 RN Structure-based alignment and comparative molecular field analysis of acetylcholinesterase inhibitors. J Med Chem. 1996 Dec 20;39(26):5064-71. DM6DH15 RU https://pubmed.ncbi.nlm.nih.gov/8978837 DMKWRFA DI DMKWRFA DMKWRFA DN (2E)-3-(2-OCT-1-YN-1-YLPHENYL)ACRYLIC ACID DMKWRFA MI TTN9T81 DMKWRFA MN Arachidonate 15-lipoxygenase (15-LOX) DMKWRFA MT DTT DMKWRFA MA Inhibitor DMKWRFA RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DMKWRFA RU https://pubmed.ncbi.nlm.nih.gov/10592235 DM3ST2Y DI DM3ST2Y DM3ST2Y DN (2E, 6E)-farnesylbisphosphonate DM3ST2Y MI TTIKWV4 DM3ST2Y MN Geranyltranstransferase (FDPS) DM3ST2Y MT DTT DM3ST2Y MA Inhibitor DM3ST2Y RN Mono- and dialkyl isoprenoid bisphosphonates as geranylgeranyl diphosphate synthase inhibitors. Bioorg Med Chem. 2008 Jan 1;16(1):390-9. DM3ST2Y RU https://pubmed.ncbi.nlm.nih.gov/17905588 DMA9RIS DI DMA9RIS DMA9RIS DN (2E,4S)-4-ammoniopent-2-enoate DMA9RIS MI TT1MPAY DMA9RIS MN GABA(A) receptor alpha-1 (GABRA1) DMA9RIS MT DTT DMA9RIS MA Inhibitor DMA9RIS RN gamma-Aminobutyric acid agonists, antagonists, and uptake inhibitors. Design and therapeutic aspects. J Med Chem. 1981 Dec;24(12):1377-83. DMA9RIS RU https://pubmed.ncbi.nlm.nih.gov/6118436 DMA9RIS DI DMA9RIS DMA9RIS DN (2E,4S)-4-ammoniopent-2-enoate DMA9RIS MI TTBMV1G DMA9RIS MN GABA(A) receptor alpha-2 (GABRA2) DMA9RIS MT DTT DMA9RIS MA Inhibitor DMA9RIS RN gamma-Aminobutyric acid agonists, antagonists, and uptake inhibitors. Design and therapeutic aspects. J Med Chem. 1981 Dec;24(12):1377-83. DMA9RIS RU https://pubmed.ncbi.nlm.nih.gov/6118436 DMA9RIS DI DMA9RIS DMA9RIS DN (2E,4S)-4-ammoniopent-2-enoate DMA9RIS MI TT37EDJ DMA9RIS MN GABA(A) receptor alpha-3 (GABRA3) DMA9RIS MT DTT DMA9RIS MA Inhibitor DMA9RIS RN gamma-Aminobutyric acid agonists, antagonists, and uptake inhibitors. Design and therapeutic aspects. J Med Chem. 1981 Dec;24(12):1377-83. DMA9RIS RU https://pubmed.ncbi.nlm.nih.gov/6118436 DMA9RIS DI DMA9RIS DMA9RIS DN (2E,4S)-4-ammoniopent-2-enoate DMA9RIS MI TTNZPQ1 DMA9RIS MN GABA(A) receptor alpha-5 (GABRA5) DMA9RIS MT DTT DMA9RIS MA Inhibitor DMA9RIS RN gamma-Aminobutyric acid agonists, antagonists, and uptake inhibitors. Design and therapeutic aspects. J Med Chem. 1981 Dec;24(12):1377-83. DMA9RIS RU https://pubmed.ncbi.nlm.nih.gov/6118436 DMA9RIS DI DMA9RIS DMA9RIS DN (2E,4S)-4-ammoniopent-2-enoate DMA9RIS MI TTZA1NY DMA9RIS MN GABA(A) receptor beta-2 (GABRB2) DMA9RIS MT DTT DMA9RIS MA Inhibitor DMA9RIS RN gamma-Aminobutyric acid agonists, antagonists, and uptake inhibitors. Design and therapeutic aspects. J Med Chem. 1981 Dec;24(12):1377-83. DMA9RIS RU https://pubmed.ncbi.nlm.nih.gov/6118436 DMA9RIS DI DMA9RIS DMA9RIS DN (2E,4S)-4-ammoniopent-2-enoate DMA9RIS MI TT06RH5 DMA9RIS MN GABA(A) receptor gamma-2 (GABRG2) DMA9RIS MT DTT DMA9RIS MA Inhibitor DMA9RIS RN gamma-Aminobutyric acid agonists, antagonists, and uptake inhibitors. Design and therapeutic aspects. J Med Chem. 1981 Dec;24(12):1377-83. DMA9RIS RU https://pubmed.ncbi.nlm.nih.gov/6118436 DMA9RIS DI DMA9RIS DMA9RIS DN (2E,4S)-4-ammoniopent-2-enoate DMA9RIS MI TTNJYV2 DMA9RIS MN Gamma-aminobutyric acid receptor (GAR) DMA9RIS MT DTT DMA9RIS MA Inhibitor DMA9RIS RN gamma-Aminobutyric acid agonists, antagonists, and uptake inhibitors. Design and therapeutic aspects. J Med Chem. 1981 Dec;24(12):1377-83. DMA9RIS RU https://pubmed.ncbi.nlm.nih.gov/6118436 DMN7XT9 DI DMN7XT9 DMN7XT9 DN (2-Ethoxy-ethyl)-trimethyl-ammonium iodide DMN7XT9 MI TT1RS9F DMN7XT9 MN Acetylcholinesterase (AChE) DMN7XT9 MT DTT DMN7XT9 MA Inhibitor DMN7XT9 RN Structure-based alignment and comparative molecular field analysis of acetylcholinesterase inhibitors. J Med Chem. 1996 Dec 20;39(26):5064-71. DMN7XT9 RU https://pubmed.ncbi.nlm.nih.gov/8978837 DMFV76H DI DMFV76H DMFV76H DN (2-fluorophenyl)-(4-fluorophenyl)phenylacetamide DMFV76H MI TTMNI76 DMFV76H MN Calcium-activated potassium channel (KCN) DMFV76H MT DTT DMFV76H MA Inhibitor DMFV76H RN Novel inhibitors of the Gardos channel for the treatment of sickle cell disease. J Med Chem. 2008 Feb 28;51(4):976-82. DMFV76H RU https://pubmed.ncbi.nlm.nih.gov/18232633 DMCHJL1 DI DMCHJL1 DMCHJL1 DN (2-hydroxy-3-phenoxypropyl)(propan-2-yl)amine DMCHJL1 MI TTVG215 DMCHJL1 MN Debrisoquine 4-hydroxylase (CYP2D6) DMCHJL1 MT DTT DMCHJL1 MA Inhibitor DMCHJL1 RN A 3D-QSAR model for CYP2D6 inhibition in the aryloxypropanolamine series. Bioorg Med Chem Lett. 2005 Sep 1;15(17):3816-20. DMCHJL1 RU https://pubmed.ncbi.nlm.nih.gov/15993593 DMEZNXS DI DMEZNXS DMEZNXS DN (2-hydroxyphenyl)(4-hydroxyphenyl)methanone DMEZNXS MI TTGX0HR DMEZNXS MN Bacterial DNA ligase (Bact ligA) DMEZNXS MT DTT DMEZNXS MA Inhibitor DMEZNXS RN Identification and validation of human DNA ligase inhibitors using computer-aided drug design. J Med Chem. 2008 Aug 14;51(15):4553-62. DMEZNXS RU https://pubmed.ncbi.nlm.nih.gov/18630893 DM24E08 DI DM24E08 DM24E08 DN (2-Indol-1-yl-ethyl)-dimethyl-amine DM24E08 MI TTJQOD7 DM24E08 MN 5-HT 2A receptor (HTR2A) DM24E08 MT DTT DM24E08 MA Inhibitor DM24E08 RN Evaluation of isotryptamine derivatives at 5-HT(2) serotonin receptors. Bioorg Med Chem Lett. 2002 Jan 21;12(2):155-8. DM24E08 RU https://pubmed.ncbi.nlm.nih.gov/11755343 DMCJKOQ DI DMCJKOQ DMCJKOQ DN (2-Mercapto-ethyl)-trimethyl-ammonium iodide DMCJKOQ MI TT1RS9F DMCJKOQ MN Acetylcholinesterase (AChE) DMCJKOQ MT DTT DMCJKOQ MA Inhibitor DMCJKOQ RN Structure-based alignment and comparative molecular field analysis of acetylcholinesterase inhibitors. J Med Chem. 1996 Dec 20;39(26):5064-71. DMCJKOQ RU https://pubmed.ncbi.nlm.nih.gov/8978837 DMQWD75 DI DMQWD75 DMQWD75 DN (2-Methoxy-phenyl)-(5-phenyl-oxazol-2-yl)-amine DMQWD75 MI TTUTJGQ DMQWD75 MN Vascular endothelial growth factor receptor 2 (KDR) DMQWD75 MT DTT DMQWD75 MA Inhibitor DMQWD75 RN Discovery and evaluation of 2-anilino-5-aryloxazoles as a novel class of VEGFR2 kinase inhibitors. J Med Chem. 2005 Mar 10;48(5):1610-9. DMQWD75 RU https://pubmed.ncbi.nlm.nih.gov/15743202 DMQWD75 DI DMQWD75 DMQWD75 DN (2-Methoxy-phenyl)-(5-phenyl-oxazol-2-yl)-amine DMQWD75 MI TTDCBX5 DMQWD75 MN Vascular endothelial growth factor receptor 3 (FLT-4) DMQWD75 MT DTT DMQWD75 MA Inhibitor DMQWD75 RN Discovery and evaluation of 2-anilino-5-aryloxazoles as a novel class of VEGFR2 kinase inhibitors. J Med Chem. 2005 Mar 10;48(5):1610-9. DMQWD75 RU https://pubmed.ncbi.nlm.nih.gov/15743202 DMQWD75 DI DMQWD75 DMQWD75 DN (2-Methoxy-phenyl)-(5-phenyl-oxazol-2-yl)-amine DMQWD75 MI TT1VAUK DMQWD75 MN VEGFR1 messenger RNA (VEGFR1 mRNA) DMQWD75 MT DTT DMQWD75 MA Inhibitor DMQWD75 RN Discovery and evaluation of 2-anilino-5-aryloxazoles as a novel class of VEGFR2 kinase inhibitors. J Med Chem. 2005 Mar 10;48(5):1610-9. DMQWD75 RU https://pubmed.ncbi.nlm.nih.gov/15743202 DME6MYZ DI DME6MYZ DME6MYZ DN (2-Methyl-indol-1-yl)-propyl-pyridin-4-yl-amine DME6MYZ MI TTWG9A4 DME6MYZ MN Adrenergic receptor alpha-2A (ADRA2A) DME6MYZ MT DTT DME6MYZ MA Inhibitor DME6MYZ RN Synthesis and structure-activity relationships of N-propyl-N-(4-pyridinyl)-1H-indol-1-amine (besipirdine) and related analogs as potential therapeu... J Med Chem. 1996 Jan 19;39(2):570-81. DME6MYZ RU https://pubmed.ncbi.nlm.nih.gov/8558529 DME6MYZ DI DME6MYZ DME6MYZ DN (2-Methyl-indol-1-yl)-propyl-pyridin-4-yl-amine DME6MYZ MI TTWM4TY DME6MYZ MN Adrenergic receptor alpha-2B (ADRA2B) DME6MYZ MT DTT DME6MYZ MA Inhibitor DME6MYZ RN Synthesis and structure-activity relationships of N-propyl-N-(4-pyridinyl)-1H-indol-1-amine (besipirdine) and related analogs as potential therapeu... J Med Chem. 1996 Jan 19;39(2):570-81. DME6MYZ RU https://pubmed.ncbi.nlm.nih.gov/8558529 DME6MYZ DI DME6MYZ DME6MYZ DN (2-Methyl-indol-1-yl)-propyl-pyridin-4-yl-amine DME6MYZ MI TT2NUT5 DME6MYZ MN Adrenergic receptor alpha-2C (ADRA2C) DME6MYZ MT DTT DME6MYZ MA Inhibitor DME6MYZ RN Synthesis and structure-activity relationships of N-propyl-N-(4-pyridinyl)-1H-indol-1-amine (besipirdine) and related analogs as potential therapeu... J Med Chem. 1996 Jan 19;39(2):570-81. DME6MYZ RU https://pubmed.ncbi.nlm.nih.gov/8558529 DMQ2XUE DI DMQ2XUE DMQ2XUE DN (2R)-1-(2,6-dimethylphenoxy)propan-2-amine DMQ2XUE MI TTGY7WI DMQ2XUE MN Urokinase-type plasminogen activator (PLAU) DMQ2XUE MT DTT DMQ2XUE MA Inhibitor DMQ2XUE RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DMQ2XUE RU https://pubmed.ncbi.nlm.nih.gov/10592235 DM3K2TI DI DM3K2TI DM3K2TI DN (2R)-2-Methyl-4,5-dideoxy DM3K2TI MI TTZ3IFB DM3K2TI MN Phosphogluconate dehydrogenase (PGD) DM3K2TI MT DTT DM3K2TI MA Inhibitor DM3K2TI RN Synthesis and biological evaluation of substrate-based inhibitors of 6-phosphogluconate dehydrogenase as potential drugs against African trypanosomiasis. Bioorg Med Chem. 2003 Jul 17;11(14):3205-14. DM3K2TI RU https://pubmed.ncbi.nlm.nih.gov/12818683 DMXPQU6 DI DMXPQU6 DMXPQU6 DN (2R)-N-(6-(4-CHLOROPHENYL)-7-(2,4-DICHLOROPHENYL)-2,2-DIMETHYL-3,4-DIHYDRO-2H-PYRANO[2,3-B]PYRIDIN-4-YL)-2-HYDROXYPROPANAMIDE (ENANTIOMERIC MIX) DMXPQU6 MI TT6OEDT DMXPQU6 MN Cannabinoid receptor 1 (CB1) DMXPQU6 MT DTT DMXPQU6 MA Inhibitor DMXPQU6 RN Dihydro-pyrano[2,3-b]pyridines and tetrahydro-1,8-naphthyridines as CB1 receptor inverse agonists: synthesis, SAR and biological evaluation. Bioorg Med Chem Lett. 2010 Jun 15;20(12):3750-4. DMXPQU6 RU https://pubmed.ncbi.nlm.nih.gov/20483606 DMXPQU6 DI DMXPQU6 DMXPQU6 DN (2R)-N-(6-(4-CHLOROPHENYL)-7-(2,4-DICHLOROPHENYL)-2,2-DIMETHYL-3,4-DIHYDRO-2H-PYRANO[2,3-B]PYRIDIN-4-YL)-2-HYDROXYPROPANAMIDE (ENANTIOMERIC MIX) DMXPQU6 MI TTMSFAW DMXPQU6 MN Cannabinoid receptor 2 (CB2) DMXPQU6 MT DTT DMXPQU6 MA Inhibitor DMXPQU6 RN Dihydro-pyrano[2,3-b]pyridines and tetrahydro-1,8-naphthyridines as CB1 receptor inverse agonists: synthesis, SAR and biological evaluation. Bioorg Med Chem Lett. 2010 Jun 15;20(12):3750-4. DMXPQU6 RU https://pubmed.ncbi.nlm.nih.gov/20483606 DMXPQU6 DI DMXPQU6 DMXPQU6 DN (2R)-N-(6-(4-CHLOROPHENYL)-7-(2,4-DICHLOROPHENYL)-2,2-DIMETHYL-3,4-DIHYDRO-2H-PYRANO[2,3-B]PYRIDIN-4-YL)-2-HYDROXYPROPANAMIDE (ENANTIOMERIC MIX) DMXPQU6 MI TTQ6VDM DMXPQU6 MN Voltage-gated potassium channel Kv11.1 (KCNH2) DMXPQU6 MT DTT DMXPQU6 MA Inhibitor DMXPQU6 RN Dihydro-pyrano[2,3-b]pyridines and tetrahydro-1,8-naphthyridines as CB1 receptor inverse agonists: synthesis, SAR and biological evaluation. Bioorg Med Chem Lett. 2010 Jun 15;20(12):3750-4. DMXPQU6 RU https://pubmed.ncbi.nlm.nih.gov/20483606 DMX0YIV DI DMX0YIV DMX0YIV DN (2R)-N-(7'-(2-CHLOROPHENYL)-6'-(4-CHLOROPHENYL)-3',4'-DIHYDROSPIRO[CYCLOHEXANE-1,2'-PYRANO[2,3-B]PYRIDINE]-4'-YL)-2-HYDROXYPROPANAMIDE (ENANTIOMERIC MIX) DMX0YIV MI TT6OEDT DMX0YIV MN Cannabinoid receptor 1 (CB1) DMX0YIV MT DTT DMX0YIV MA Inhibitor DMX0YIV RN Dihydro-pyrano[2,3-b]pyridines and tetrahydro-1,8-naphthyridines as CB1 receptor inverse agonists: synthesis, SAR and biological evaluation. Bioorg Med Chem Lett. 2010 Jun 15;20(12):3750-4. DMX0YIV RU https://pubmed.ncbi.nlm.nih.gov/20483606 DMX0YIV DI DMX0YIV DMX0YIV DN (2R)-N-(7'-(2-CHLOROPHENYL)-6'-(4-CHLOROPHENYL)-3',4'-DIHYDROSPIRO[CYCLOHEXANE-1,2'-PYRANO[2,3-B]PYRIDINE]-4'-YL)-2-HYDROXYPROPANAMIDE (ENANTIOMERIC MIX) DMX0YIV MI TTMSFAW DMX0YIV MN Cannabinoid receptor 2 (CB2) DMX0YIV MT DTT DMX0YIV MA Inhibitor DMX0YIV RN Dihydro-pyrano[2,3-b]pyridines and tetrahydro-1,8-naphthyridines as CB1 receptor inverse agonists: synthesis, SAR and biological evaluation. Bioorg Med Chem Lett. 2010 Jun 15;20(12):3750-4. DMX0YIV RU https://pubmed.ncbi.nlm.nih.gov/20483606 DMYRHFI DI DMYRHFI DMYRHFI DN (2R,3R)-iodoreboxetine DMYRHFI MI TTVBI8W DMYRHFI MN Dopamine transporter (DAT) DMYRHFI MT DTT DMYRHFI MA Inhibitor DMYRHFI RN New iodoreboxetine analogues for SPECT imaging of the noradrenaline transporter. Bioorg Med Chem Lett. 2008 Sep 15;18(18):4940-3. DMYRHFI RU https://pubmed.ncbi.nlm.nih.gov/18762424 DMYRHFI DI DMYRHFI DMYRHFI DN (2R,3R)-iodoreboxetine DMYRHFI MI TT3ROYC DMYRHFI MN Serotonin transporter (SERT) DMYRHFI MT DTT DMYRHFI MA Inhibitor DMYRHFI RN New iodoreboxetine analogues for SPECT imaging of the noradrenaline transporter. Bioorg Med Chem Lett. 2008 Sep 15;18(18):4940-3. DMYRHFI RU https://pubmed.ncbi.nlm.nih.gov/18762424 DMY2FX8 DI DMY2FX8 DMY2FX8 DN (2R,3S)-2-[(2-Iodophenoxy)phenylmethyl]morpholine DMY2FX8 MI TTVBI8W DMY2FX8 MN Dopamine transporter (DAT) DMY2FX8 MT DTT DMY2FX8 MA Inhibitor DMY2FX8 RN Design and synthesis of (2R,3S)-iodoreboxetine analogues for SPECT imaging of the noradrenaline transporter. Bioorg Med Chem Lett. 2009 Sep 1;19(17):4996-8. DMY2FX8 RU https://pubmed.ncbi.nlm.nih.gov/19640707 DMY2FX8 DI DMY2FX8 DMY2FX8 DN (2R,3S)-2-[(2-Iodophenoxy)phenylmethyl]morpholine DMY2FX8 MI TT3ROYC DMY2FX8 MN Serotonin transporter (SERT) DMY2FX8 MT DTT DMY2FX8 MA Inhibitor DMY2FX8 RN Design and synthesis of (2R,3S)-iodoreboxetine analogues for SPECT imaging of the noradrenaline transporter. Bioorg Med Chem Lett. 2009 Sep 1;19(17):4996-8. DMY2FX8 RU https://pubmed.ncbi.nlm.nih.gov/19640707 DM260TI DI DM260TI DM260TI DN (2R,3S)-2-[(3-Iodophenoxy)phenylmethyl]morpholine DM260TI MI TTVBI8W DM260TI MN Dopamine transporter (DAT) DM260TI MT DTT DM260TI MA Inhibitor DM260TI RN Design and synthesis of (2R,3S)-iodoreboxetine analogues for SPECT imaging of the noradrenaline transporter. Bioorg Med Chem Lett. 2009 Sep 1;19(17):4996-8. DM260TI RU https://pubmed.ncbi.nlm.nih.gov/19640707 DM260TI DI DM260TI DM260TI DN (2R,3S)-2-[(3-Iodophenoxy)phenylmethyl]morpholine DM260TI MI TT3ROYC DM260TI MN Serotonin transporter (SERT) DM260TI MT DTT DM260TI MA Inhibitor DM260TI RN Design and synthesis of (2R,3S)-iodoreboxetine analogues for SPECT imaging of the noradrenaline transporter. Bioorg Med Chem Lett. 2009 Sep 1;19(17):4996-8. DM260TI RU https://pubmed.ncbi.nlm.nih.gov/19640707 DMKM8E2 DI DMKM8E2 DMKM8E2 DN (2R,3S)-2-[(4-Iodophenoxy)phenylmethyl]morpholine DMKM8E2 MI TTVBI8W DMKM8E2 MN Dopamine transporter (DAT) DMKM8E2 MT DTT DMKM8E2 MA Inhibitor DMKM8E2 RN Design and synthesis of (2R,3S)-iodoreboxetine analogues for SPECT imaging of the noradrenaline transporter. Bioorg Med Chem Lett. 2009 Sep 1;19(17):4996-8. DMKM8E2 RU https://pubmed.ncbi.nlm.nih.gov/19640707 DMKM8E2 DI DMKM8E2 DMKM8E2 DN (2R,3S)-2-[(4-Iodophenoxy)phenylmethyl]morpholine DMKM8E2 MI TT3ROYC DMKM8E2 MN Serotonin transporter (SERT) DMKM8E2 MT DTT DMKM8E2 MA Inhibitor DMKM8E2 RN Design and synthesis of (2R,3S)-iodoreboxetine analogues for SPECT imaging of the noradrenaline transporter. Bioorg Med Chem Lett. 2009 Sep 1;19(17):4996-8. DMKM8E2 RU https://pubmed.ncbi.nlm.nih.gov/19640707 DM852Z6 DI DM852Z6 DM852Z6 DN (2R,3S)-3-(6-Amino-purin-9-yl)-nonan-2-ol DM852Z6 MI TTM2AOE DM852Z6 MN Adenosine A2a receptor (ADORA2A) DM852Z6 MT DTT DM852Z6 MA Inhibitor DM852Z6 RN Structure-activity relationships of 9-alkyladenine and ribose-modified adenosine derivatives at rat A3 adenosine receptors. J Med Chem. 1995 May 12;38(10):1720-35. DM852Z6 RU https://pubmed.ncbi.nlm.nih.gov/7752196 DM852Z6 DI DM852Z6 DM852Z6 DN (2R,3S)-3-(6-Amino-purin-9-yl)-nonan-2-ol DM852Z6 MI TTJFY5U DM852Z6 MN Adenosine A3 receptor (ADORA3) DM852Z6 MT DTT DM852Z6 MA Inhibitor DM852Z6 RN Structure-activity relationships of 9-alkyladenine and ribose-modified adenosine derivatives at rat A3 adenosine receptors. J Med Chem. 1995 May 12;38(10):1720-35. DM852Z6 RU https://pubmed.ncbi.nlm.nih.gov/7752196 DM852Z6 DI DM852Z6 DM852Z6 DN (2R,3S)-3-(6-Amino-purin-9-yl)-nonan-2-ol DM852Z6 MI TTJGW1Z DM852Z6 MN Phosphodiesterase 2A (PDE2A) DM852Z6 MT DTT DM852Z6 MA Inhibitor DM852Z6 RN The next generation of phosphodiesterase inhibitors: structural clues to ligand and substrate selectivity of phosphodiesterases. J Med Chem. 2005 May 19;48(10):3449-62. DM852Z6 RU https://pubmed.ncbi.nlm.nih.gov/15887951 DMDS8AN DI DMDS8AN DMDS8AN DN (2R,3S,4S,5R)-2-hexylpiperidine-3,4,5-triol DMDS8AN MI TT1B5PU DMDS8AN MN Glucosylceramidase (GBA) DMDS8AN MT DTT DMDS8AN MA Inhibitor DMDS8AN RN Synthesis of new beta-1-C-alkylated imino-L-iditols: A comparative study of their activity as beta-glucocerebrosidase inhibitors. Bioorg Med Chem. 2010 Apr 1;18(7):2645-50. DMDS8AN RU https://pubmed.ncbi.nlm.nih.gov/20231099 DMIQNX9 DI DMIQNX9 DMIQNX9 DN (2R,3S,4S,5R)-2-nonylpiperidine-3,4,5-triol DMIQNX9 MI TT1B5PU DMIQNX9 MN Glucosylceramidase (GBA) DMIQNX9 MT DTT DMIQNX9 MA Inhibitor DMIQNX9 RN Synthesis of new beta-1-C-alkylated imino-L-iditols: A comparative study of their activity as beta-glucocerebrosidase inhibitors. Bioorg Med Chem. 2010 Apr 1;18(7):2645-50. DMIQNX9 RU https://pubmed.ncbi.nlm.nih.gov/20231099 DM7GI94 DI DM7GI94 DM7GI94 DN (2R,3S,4S,5R)-2-propylpiperidine-3,4,5-triol DM7GI94 MI TT1B5PU DM7GI94 MN Glucosylceramidase (GBA) DM7GI94 MT DTT DM7GI94 MA Inhibitor DM7GI94 RN Synthesis of new beta-1-C-alkylated imino-L-iditols: A comparative study of their activity as beta-glucocerebrosidase inhibitors. Bioorg Med Chem. 2010 Apr 1;18(7):2645-50. DM7GI94 RU https://pubmed.ncbi.nlm.nih.gov/20231099 DMYW40T DI DMYW40T DMYW40T DN (2R,4R)-4-aminopyrrolidine-2,4-dicarboxylate DMYW40T MI TTXJ47W DMYW40T MN Metabotropic glutamate receptor 2 (mGluR2) DMYW40T MT DTT DMYW40T MA Agonist DMYW40T RN Group II metabotropic glutamate receptors within the amygdala regulate fear as assessed with potentiated startle in rats. Behav Neurosci. 2002 Dec;116(6):1075-83. DMYW40T RU https://pubmed.ncbi.nlm.nih.gov/12492306 DMSFXEO DI DMSFXEO DMSFXEO DN (2R,5R)-delta-methyl-alpha-acetylenic putrescine DMSFXEO MI TTUMGNO DMSFXEO MN Ornithine decarboxylase (ODC1) DMSFXEO MT DTT DMSFXEO MA Inhibitor DMSFXEO RN Plasmodium falciparum and Plasmodium berghei: effects of ornithine decarboxylase inhibitors on erythrocytic schizogony. Exp Parasitol. 1987 Oct;64(2):237-43. DMSFXEO RU https://pubmed.ncbi.nlm.nih.gov/3115816 DMIS39C DI DMIS39C DMIS39C DN (2S)-1-(1H-furo[2,3-g]indazol-1-yl)propan-2-amine DMIS39C MI TTJQOD7 DMIS39C MN 5-HT 2A receptor (HTR2A) DMIS39C MT DTT DMIS39C MA Inhibitor DMIS39C RN Synthesis and structure-activity relationships of a series of substituted 2-(1H-furo[2,3-g]indazol-1-yl)ethylamine derivatives as 5-HT2C receptor a... Bioorg Med Chem. 2008 Feb 15;16(4):1966-82. DMIS39C RU https://pubmed.ncbi.nlm.nih.gov/18035544 DMIS39C DI DMIS39C DMIS39C DN (2S)-1-(1H-furo[2,3-g]indazol-1-yl)propan-2-amine DMIS39C MI TTWJBZ5 DMIS39C MN 5-HT 2C receptor (HTR2C) DMIS39C MT DTT DMIS39C MA Inhibitor DMIS39C RN Synthesis and structure-activity relationships of a series of substituted 2-(1H-furo[2,3-g]indazol-1-yl)ethylamine derivatives as 5-HT2C receptor a... Bioorg Med Chem. 2008 Feb 15;16(4):1966-82. DMIS39C RU https://pubmed.ncbi.nlm.nih.gov/18035544 DMW4ARM DI DMW4ARM DMW4ARM DN (2S)-1-(5-fluoro-1H-indazol-1-yl)propan-2-amine DMW4ARM MI TTJQOD7 DMW4ARM MN 5-HT 2A receptor (HTR2A) DMW4ARM MT DTT DMW4ARM MA Inhibitor DMW4ARM RN Synthesis and structure-activity relationships of a series of substituted 2-(1H-furo[2,3-g]indazol-1-yl)ethylamine derivatives as 5-HT2C receptor a... Bioorg Med Chem. 2008 Feb 15;16(4):1966-82. DMW4ARM RU https://pubmed.ncbi.nlm.nih.gov/18035544 DMW4ARM DI DMW4ARM DMW4ARM DN (2S)-1-(5-fluoro-1H-indazol-1-yl)propan-2-amine DMW4ARM MI TTWJBZ5 DMW4ARM MN 5-HT 2C receptor (HTR2C) DMW4ARM MT DTT DMW4ARM MA Inhibitor DMW4ARM RN Synthesis and structure-activity relationships of a series of substituted 2-(1H-furo[2,3-g]indazol-1-yl)ethylamine derivatives as 5-HT2C receptor a... Bioorg Med Chem. 2008 Feb 15;16(4):1966-82. DMW4ARM RU https://pubmed.ncbi.nlm.nih.gov/18035544 DM31SNW DI DM31SNW DM31SNW DN (2S)-1-(6-fluoro-1H-indazol-1-yl)propan-2-amine DM31SNW MI TTJQOD7 DM31SNW MN 5-HT 2A receptor (HTR2A) DM31SNW MT DTT DM31SNW MA Inhibitor DM31SNW RN Synthesis and structure-activity relationships of a series of substituted 2-(1H-furo[2,3-g]indazol-1-yl)ethylamine derivatives as 5-HT2C receptor a... Bioorg Med Chem. 2008 Feb 15;16(4):1966-82. DM31SNW RU https://pubmed.ncbi.nlm.nih.gov/18035544 DM31SNW DI DM31SNW DM31SNW DN (2S)-1-(6-fluoro-1H-indazol-1-yl)propan-2-amine DM31SNW MI TTWJBZ5 DM31SNW MN 5-HT 2C receptor (HTR2C) DM31SNW MT DTT DM31SNW MA Inhibitor DM31SNW RN Synthesis and structure-activity relationships of a series of substituted 2-(1H-furo[2,3-g]indazol-1-yl)ethylamine derivatives as 5-HT2C receptor a... Bioorg Med Chem. 2008 Feb 15;16(4):1966-82. DM31SNW RU https://pubmed.ncbi.nlm.nih.gov/18035544 DMYALON DI DMYALON DMYALON DN (2S)-1-(6-methoxy-1H-indazol-1-yl)propan-2-amine DMYALON MI TTJQOD7 DMYALON MN 5-HT 2A receptor (HTR2A) DMYALON MT DTT DMYALON MA Inhibitor DMYALON RN 1-((S)-2-aminopropyl)-1H-indazol-6-ol: a potent peripherally acting 5-HT2 receptor agonist with ocular hypotensive activity. J Med Chem. 2006 Jan 12;49(1):318-28. DMYALON RU https://pubmed.ncbi.nlm.nih.gov/16392816 DMYALON DI DMYALON DMYALON DN (2S)-1-(6-methoxy-1H-indazol-1-yl)propan-2-amine DMYALON MI TT0K1SC DMYALON MN 5-HT 2B receptor (HTR2B) DMYALON MT DTT DMYALON MA Inhibitor DMYALON RN 1-((S)-2-aminopropyl)-1H-indazol-6-ol: a potent peripherally acting 5-HT2 receptor agonist with ocular hypotensive activity. J Med Chem. 2006 Jan 12;49(1):318-28. DMYALON RU https://pubmed.ncbi.nlm.nih.gov/16392816 DMYALON DI DMYALON DMYALON DN (2S)-1-(6-methoxy-1H-indazol-1-yl)propan-2-amine DMYALON MI TTWJBZ5 DMYALON MN 5-HT 2C receptor (HTR2C) DMYALON MT DTT DMYALON MA Inhibitor DMYALON RN Synthesis and structure-activity relationships of a series of substituted 2-(1H-furo[2,3-g]indazol-1-yl)ethylamine derivatives as 5-HT2C receptor a... Bioorg Med Chem. 2008 Feb 15;16(4):1966-82. DMYALON RU https://pubmed.ncbi.nlm.nih.gov/18035544 DMNKEUG DI DMNKEUG DMNKEUG DN (2S)-2-(4-chlorophenoxy)-3-phenylpropanoic acid DMNKEUG MI TTZMAO3 DMNKEUG MN Peroxisome proliferator-activated receptor gamma (PPAR-gamma) DMNKEUG MT DTT DMNKEUG MA Inhibitor DMNKEUG RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DMNKEUG RU https://pubmed.ncbi.nlm.nih.gov/10592235 DMYBXHF DI DMYBXHF DMYBXHF DN (2S)-2-(4-ethylphenoxy)-3-phenylpropanoic acid DMYBXHF MI TTZMAO3 DMYBXHF MN Peroxisome proliferator-activated receptor gamma (PPAR-gamma) DMYBXHF MT DTT DMYBXHF MA Inhibitor DMYBXHF RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DMYBXHF RU https://pubmed.ncbi.nlm.nih.gov/10592235 DM73TPQ DI DM73TPQ DM73TPQ DN (2S)-2-(biphenyl-4-yloxy)-3-phenylpropanoic acid DM73TPQ MI TTZMAO3 DM73TPQ MN Peroxisome proliferator-activated receptor gamma (PPAR-gamma) DM73TPQ MT DTT DM73TPQ MA Inhibitor DM73TPQ RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DM73TPQ RU https://pubmed.ncbi.nlm.nih.gov/10592235 DMMP8TR DI DMMP8TR DMMP8TR DN (2S)-2-(BUTYRYLOXY)-3-HYDROXYPROPYL NONANOATE DMMP8TR MI TTYOMFZ DMMP8TR MN Voltage-gated potassium channel (VGKC) DMMP8TR MT DTT DMMP8TR MA Inhibitor DMMP8TR RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DMMP8TR RU https://pubmed.ncbi.nlm.nih.gov/10592235 DMZOX43 DI DMZOX43 DMZOX43 DN (2S)-2'-methoxy kurarinone DMZOX43 MI TT8JRS7 DMZOX43 MN Beta-secretase (BACE) DMZOX43 MT DTT DMZOX43 MA Inhibitor DMZOX43 RN BACE1 inhibitory effects of lavandulyl flavanones from Sophora flavescens. Bioorg Med Chem. 2008 Jul 15;16(14):6669-74. DMZOX43 RU https://pubmed.ncbi.nlm.nih.gov/18565755 DMYVBHT DI DMYVBHT DMYVBHT DN (2S)-5,7,2',4'-tetrahydroxyflavanone DMYVBHT MI TTSZLWK DMYVBHT MN Aromatase (CYP19A1) DMYVBHT MT DTT DMYVBHT MA Inhibitor DMYVBHT RN Aromatase inhibitors from Broussonetia papyrifera. J Nat Prod. 2001 Oct;64(10):1286-93. DMYVBHT RU https://pubmed.ncbi.nlm.nih.gov/11678652 DM5V3M1 DI DM5V3M1 DM5V3M1 DN (2S)-abyssinone II DM5V3M1 MI TTSZLWK DM5V3M1 MN Aromatase (CYP19A1) DM5V3M1 MT DTT DM5V3M1 MA Inhibitor DM5V3M1 RN Aromatase inhibitors from Broussonetia papyrifera. J Nat Prod. 2001 Oct;64(10):1286-93. DM5V3M1 RU https://pubmed.ncbi.nlm.nih.gov/11678652 DMWQK86 DI DMWQK86 DMWQK86 DN (2S)-aminobutyryl-(R)-pipecolinic acid amide DMWQK86 MI TTQ7R2V DMWQK86 MN Tripeptidyl-peptidase II (TPP2) DMWQK86 MT DTT DMWQK86 MA Inhibitor DMWQK86 RN Inhibitors of tripeptidyl peptidase II. 3. Derivation of butabindide by successive structure optimizations leading to a potential general approach ... J Med Chem. 2005 Nov 17;48(23):7333-42. DMWQK86 RU https://pubmed.ncbi.nlm.nih.gov/16279793 DMG0QKL DI DMG0QKL DMG0QKL DN (2S)-aminobutyryl-L-prolinamide DMG0QKL MI TTQ7R2V DMG0QKL MN Tripeptidyl-peptidase II (TPP2) DMG0QKL MT DTT DMG0QKL MA Inhibitor DMG0QKL RN Inhibitors of tripeptidyl peptidase II. 3. Derivation of butabindide by successive structure optimizations leading to a potential general approach ... J Med Chem. 2005 Nov 17;48(23):7333-42. DMG0QKL RU https://pubmed.ncbi.nlm.nih.gov/16279793 DMTFP0Z DI DMTFP0Z DMTFP0Z DN (2S)-aminobutyryl-L-proline (R)-sec-butylamide DMTFP0Z MI TTQ7R2V DMTFP0Z MN Tripeptidyl-peptidase II (TPP2) DMTFP0Z MT DTT DMTFP0Z MA Inhibitor DMTFP0Z RN Inhibitors of tripeptidyl peptidase II. 3. Derivation of butabindide by successive structure optimizations leading to a potential general approach ... J Med Chem. 2005 Nov 17;48(23):7333-42. DMTFP0Z RU https://pubmed.ncbi.nlm.nih.gov/16279793 DMO5ZEK DI DMO5ZEK DMO5ZEK DN (2S)-aminobutyryl-L-proline isobutylamide DMO5ZEK MI TTQ7R2V DMO5ZEK MN Tripeptidyl-peptidase II (TPP2) DMO5ZEK MT DTT DMO5ZEK MA Inhibitor DMO5ZEK RN Inhibitors of tripeptidyl peptidase II. 3. Derivation of butabindide by successive structure optimizations leading to a potential general approach ... J Med Chem. 2005 Nov 17;48(23):7333-42. DMO5ZEK RU https://pubmed.ncbi.nlm.nih.gov/16279793 DM12Q9O DI DM12Q9O DM12Q9O DN (2S)-aminobutyryl-L-proline n-butylamide DM12Q9O MI TTQ7R2V DM12Q9O MN Tripeptidyl-peptidase II (TPP2) DM12Q9O MT DTT DM12Q9O MA Inhibitor DM12Q9O RN Inhibitors of tripeptidyl peptidase II. 3. Derivation of butabindide by successive structure optimizations leading to a potential general approach ... J Med Chem. 2005 Nov 17;48(23):7333-42. DM12Q9O RU https://pubmed.ncbi.nlm.nih.gov/16279793 DM1DJX2 DI DM1DJX2 DM1DJX2 DN (2S)-aminobutyryl-L-proline n-pentylamide DM1DJX2 MI TTQ7R2V DM1DJX2 MN Tripeptidyl-peptidase II (TPP2) DM1DJX2 MT DTT DM1DJX2 MA Inhibitor DM1DJX2 RN Inhibitors of tripeptidyl peptidase II. 3. Derivation of butabindide by successive structure optimizations leading to a potential general approach ... J Med Chem. 2005 Nov 17;48(23):7333-42. DM1DJX2 RU https://pubmed.ncbi.nlm.nih.gov/16279793 DM6WXJO DI DM6WXJO DM6WXJO DN (2S)-aminobutyryl-L-proline n-propylamide DM6WXJO MI TTQ7R2V DM6WXJO MN Tripeptidyl-peptidase II (TPP2) DM6WXJO MT DTT DM6WXJO MA Inhibitor DM6WXJO RN Inhibitors of tripeptidyl peptidase II. 3. Derivation of butabindide by successive structure optimizations leading to a potential general approach ... J Med Chem. 2005 Nov 17;48(23):7333-42. DM6WXJO RU https://pubmed.ncbi.nlm.nih.gov/16279793 DMEWU6Z DI DMEWU6Z DMEWU6Z DN (2S)-aminobutyryl-L-proline-(2S)-methylbutylamide DMEWU6Z MI TTQ7R2V DMEWU6Z MN Tripeptidyl-peptidase II (TPP2) DMEWU6Z MT DTT DMEWU6Z MA Inhibitor DMEWU6Z RN Inhibitors of tripeptidyl peptidase II. 3. Derivation of butabindide by successive structure optimizations leading to a potential general approach ... J Med Chem. 2005 Nov 17;48(23):7333-42. DMEWU6Z RU https://pubmed.ncbi.nlm.nih.gov/16279793 DM6L0KZ DI DM6L0KZ DM6L0KZ DN (2S)-euchrenone a7 DM6L0KZ MI TTSZLWK DM6L0KZ MN Aromatase (CYP19A1) DM6L0KZ MT DTT DM6L0KZ MA Inhibitor DM6L0KZ RN Aromatase inhibitors from Broussonetia papyrifera. J Nat Prod. 2001 Oct;64(10):1286-93. DM6L0KZ RU https://pubmed.ncbi.nlm.nih.gov/11678652 DMRCMIT DI DMRCMIT DMRCMIT DN (2S)-N-(7'-(2-CHLOROPHENYL)-6'-(4-CHLOROPHENYL)-3',4'-DIHYDROSPIRO[CYCLOHEXANE-1,2'-PYRANO[2,3-B]PYRIDINE]-4'-YL)-2-HYDROXYPROPANAMIDE (ENANTIOMERIC MIX) DMRCMIT MI TT6OEDT DMRCMIT MN Cannabinoid receptor 1 (CB1) DMRCMIT MT DTT DMRCMIT MA Inhibitor DMRCMIT RN Dihydro-pyrano[2,3-b]pyridines and tetrahydro-1,8-naphthyridines as CB1 receptor inverse agonists: synthesis, SAR and biological evaluation. Bioorg Med Chem Lett. 2010 Jun 15;20(12):3750-4. DMRCMIT RU https://pubmed.ncbi.nlm.nih.gov/20483606 DMRCMIT DI DMRCMIT DMRCMIT DN (2S)-N-(7'-(2-CHLOROPHENYL)-6'-(4-CHLOROPHENYL)-3',4'-DIHYDROSPIRO[CYCLOHEXANE-1,2'-PYRANO[2,3-B]PYRIDINE]-4'-YL)-2-HYDROXYPROPANAMIDE (ENANTIOMERIC MIX) DMRCMIT MI TTMSFAW DMRCMIT MN Cannabinoid receptor 2 (CB2) DMRCMIT MT DTT DMRCMIT MA Inhibitor DMRCMIT RN Dihydro-pyrano[2,3-b]pyridines and tetrahydro-1,8-naphthyridines as CB1 receptor inverse agonists: synthesis, SAR and biological evaluation. Bioorg Med Chem Lett. 2010 Jun 15;20(12):3750-4. DMRCMIT RU https://pubmed.ncbi.nlm.nih.gov/20483606 DMZON3T DI DMZON3T DMZON3T DN (2s)-Pyrrolidin-2-Ylmethylamine DMZON3T MI TTDIGC1 DMZON3T MN Dipeptidyl peptidase 4 (DPP-4) DMZON3T MT DTT DMZON3T MA Inhibitor DMZON3T RN DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Nucleic Acids Res. 2011 Jan;39(Database issue):D1035-41. DMZON3T RU https://pubmed.ncbi.nlm.nih.gov/21059682 DMLS29E DI DMLS29E DMLS29E DN (2S,1'R,2'S)-2-(2'-phosphonocyclopropyl)glycine DMLS29E MI TTICZ1O DMLS29E MN Metabotropic glutamate receptor 4 (mGluR4) DMLS29E MT DTT DMLS29E MA Inhibitor DMLS29E RN Synthesis and preliminary pharmacological evaluation of the four stereoisomers of (2S)-2-(2'-phosphono-3'-phenylcyclopropyl)glycine, the first clas... Bioorg Med Chem. 2007 May 1;15(9):3161-70. DMLS29E RU https://pubmed.ncbi.nlm.nih.gov/17350267 DMJE83O DI DMJE83O DMJE83O DN (2S,3R)-2-(benzyloxy)-3-methoxycyclohexanone DMJE83O MI TT9W8GU DMJE83O MN Gamma-secretase (GS) DMJE83O MT DTT DMJE83O MA Inhibitor DMJE83O RN Novel gamma-secretase inhibitors discovered by library screening of in-house synthetic natural product intermediates. Bioorg Med Chem Lett. 2006 Jul 15;16(14):3813-6. DMJE83O RU https://pubmed.ncbi.nlm.nih.gov/16682195 DMJE83O DI DMJE83O DMJE83O DN (2S,3R)-2-(benzyloxy)-3-methoxycyclohexanone DMJE83O MI TTZ3S8C DMJE83O MN Presenilin 1 (PSEN1) DMJE83O MT DTT DMJE83O MA Inhibitor DMJE83O RN Novel gamma-secretase inhibitors discovered by library screening of in-house synthetic natural product intermediates. Bioorg Med Chem Lett. 2006 Jul 15;16(14):3813-6. DMJE83O RU https://pubmed.ncbi.nlm.nih.gov/16682195 DMJE83O DI DMJE83O DMJE83O DN (2S,3R)-2-(benzyloxy)-3-methoxycyclohexanone DMJE83O MI TTWN3F4 DMJE83O MN Presenilin 2 (PSEN2) DMJE83O MT DTT DMJE83O MA Inhibitor DMJE83O RN Novel gamma-secretase inhibitors discovered by library screening of in-house synthetic natural product intermediates. Bioorg Med Chem Lett. 2006 Jul 15;16(14):3813-6. DMJE83O RU https://pubmed.ncbi.nlm.nih.gov/16682195 DM4JQCR DI DM4JQCR DM4JQCR DN (2S,3R)-3-(6-amino-9H-purin-9-yl)nonan-2-ol DM4JQCR MI TTLP57V DM4JQCR MN Adenosine deaminase (ADA) DM4JQCR MT DTT DM4JQCR MA Inhibitor DM4JQCR RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DM4JQCR RU https://pubmed.ncbi.nlm.nih.gov/10592235 DMDUI8R DI DMDUI8R DMDUI8R DN (2S,3S)-2-(m-Tolyl)-3,5,5-trimethylmorpholin-2-ol DMDUI8R MI TTVBI8W DMDUI8R MN Dopamine transporter (DAT) DMDUI8R MT DTT DMDUI8R MA Inhibitor DMDUI8R RN Synthesis and characterization of in vitro and in vivo profiles of hydroxybupropion analogues: aids to smoking cessation. J Med Chem. 2010 Jun 24;53(12):4731-48. DMDUI8R RU https://pubmed.ncbi.nlm.nih.gov/20509659 DMDUI8R DI DMDUI8R DMDUI8R DN (2S,3S)-2-(m-Tolyl)-3,5,5-trimethylmorpholin-2-ol DMDUI8R MI TT4H1MQ DMDUI8R MN Neuronal acetylcholine receptor alpha-4 (CHRNA4) DMDUI8R MT DTT DMDUI8R MA Inhibitor DMDUI8R RN Synthesis and characterization of in vitro and in vivo profiles of hydroxybupropion analogues: aids to smoking cessation. J Med Chem. 2010 Jun 24;53(12):4731-48. DMDUI8R RU https://pubmed.ncbi.nlm.nih.gov/20509659 DMDUI8R DI DMDUI8R DMDUI8R DN (2S,3S)-2-(m-Tolyl)-3,5,5-trimethylmorpholin-2-ol DMDUI8R MI TT5KPZR DMDUI8R MN Neuronal acetylcholine receptor beta-2 (CHRNB2) DMDUI8R MT DTT DMDUI8R MA Inhibitor DMDUI8R RN Synthesis and characterization of in vitro and in vivo profiles of hydroxybupropion analogues: aids to smoking cessation. J Med Chem. 2010 Jun 24;53(12):4731-48. DMDUI8R RU https://pubmed.ncbi.nlm.nih.gov/20509659 DMDUI8R DI DMDUI8R DMDUI8R DN (2S,3S)-2-(m-Tolyl)-3,5,5-trimethylmorpholin-2-ol DMDUI8R MI TTTVAFQ DMDUI8R MN Neuronal acetylcholine receptor beta-4 (CHRNB4) DMDUI8R MT DTT DMDUI8R MA Inhibitor DMDUI8R RN Synthesis and characterization of in vitro and in vivo profiles of hydroxybupropion analogues: aids to smoking cessation. J Med Chem. 2010 Jun 24;53(12):4731-48. DMDUI8R RU https://pubmed.ncbi.nlm.nih.gov/20509659 DMDUI8R DI DMDUI8R DMDUI8R DN (2S,3S)-2-(m-Tolyl)-3,5,5-trimethylmorpholin-2-ol DMDUI8R MI TTAWNKZ DMDUI8R MN Norepinephrine transporter (NET) DMDUI8R MT DTT DMDUI8R MA Inhibitor DMDUI8R RN Synthesis and characterization of in vitro and in vivo profiles of hydroxybupropion analogues: aids to smoking cessation. J Med Chem. 2010 Jun 24;53(12):4731-48. DMDUI8R RU https://pubmed.ncbi.nlm.nih.gov/20509659 DMDUGZS DI DMDUGZS DMDUGZS DN (2S,3S)-2-Phenyl-3,5,5-trimethylmorpholin-2-ol DMDUGZS MI TTVBI8W DMDUGZS MN Dopamine transporter (DAT) DMDUGZS MT DTT DMDUGZS MA Inhibitor DMDUGZS RN Synthesis and characterization of in vitro and in vivo profiles of hydroxybupropion analogues: aids to smoking cessation. J Med Chem. 2010 Jun 24;53(12):4731-48. DMDUGZS RU https://pubmed.ncbi.nlm.nih.gov/20509659 DMDUGZS DI DMDUGZS DMDUGZS DN (2S,3S)-2-Phenyl-3,5,5-trimethylmorpholin-2-ol DMDUGZS MI TT4H1MQ DMDUGZS MN Neuronal acetylcholine receptor alpha-4 (CHRNA4) DMDUGZS MT DTT DMDUGZS MA Inhibitor DMDUGZS RN Synthesis and characterization of in vitro and in vivo profiles of hydroxybupropion analogues: aids to smoking cessation. J Med Chem. 2010 Jun 24;53(12):4731-48. DMDUGZS RU https://pubmed.ncbi.nlm.nih.gov/20509659 DMDUGZS DI DMDUGZS DMDUGZS DN (2S,3S)-2-Phenyl-3,5,5-trimethylmorpholin-2-ol DMDUGZS MI TT5KPZR DMDUGZS MN Neuronal acetylcholine receptor beta-2 (CHRNB2) DMDUGZS MT DTT DMDUGZS MA Inhibitor DMDUGZS RN Synthesis and characterization of in vitro and in vivo profiles of hydroxybupropion analogues: aids to smoking cessation. J Med Chem. 2010 Jun 24;53(12):4731-48. DMDUGZS RU https://pubmed.ncbi.nlm.nih.gov/20509659 DMDUGZS DI DMDUGZS DMDUGZS DN (2S,3S)-2-Phenyl-3,5,5-trimethylmorpholin-2-ol DMDUGZS MI TTTVAFQ DMDUGZS MN Neuronal acetylcholine receptor beta-4 (CHRNB4) DMDUGZS MT DTT DMDUGZS MA Inhibitor DMDUGZS RN Synthesis and characterization of in vitro and in vivo profiles of hydroxybupropion analogues: aids to smoking cessation. J Med Chem. 2010 Jun 24;53(12):4731-48. DMDUGZS RU https://pubmed.ncbi.nlm.nih.gov/20509659 DMDUGZS DI DMDUGZS DMDUGZS DN (2S,3S)-2-Phenyl-3,5,5-trimethylmorpholin-2-ol DMDUGZS MI TTAWNKZ DMDUGZS MN Norepinephrine transporter (NET) DMDUGZS MT DTT DMDUGZS MA Inhibitor DMDUGZS RN Synthesis and characterization of in vitro and in vivo profiles of hydroxybupropion analogues: aids to smoking cessation. J Med Chem. 2010 Jun 24;53(12):4731-48. DMDUGZS RU https://pubmed.ncbi.nlm.nih.gov/20509659 DMBEOIQ DI DMBEOIQ DMBEOIQ DN (2S,3S)-iodoreboxetine DMBEOIQ MI TTVBI8W DMBEOIQ MN Dopamine transporter (DAT) DMBEOIQ MT DTT DMBEOIQ MA Inhibitor DMBEOIQ RN New iodoreboxetine analogues for SPECT imaging of the noradrenaline transporter. Bioorg Med Chem Lett. 2008 Sep 15;18(18):4940-3. DMBEOIQ RU https://pubmed.ncbi.nlm.nih.gov/18762424 DMBEOIQ DI DMBEOIQ DMBEOIQ DN (2S,3S)-iodoreboxetine DMBEOIQ MI TT3ROYC DMBEOIQ MN Serotonin transporter (SERT) DMBEOIQ MT DTT DMBEOIQ MA Inhibitor DMBEOIQ RN New iodoreboxetine analogues for SPECT imaging of the noradrenaline transporter. Bioorg Med Chem Lett. 2008 Sep 15;18(18):4940-3. DMBEOIQ RU https://pubmed.ncbi.nlm.nih.gov/18762424 DMTQF2G DI DMTQF2G DMTQF2G DN (2S,4R)-4-(3-Methoxy-3-oxopropyl)glutamic Acid DMTQF2G MI TT0MYE2 DMTQF2G MN Glutamate receptor ionotropic kainate 1 (GRIK1) DMTQF2G MT DTT DMTQF2G MA Inhibitor DMTQF2G RN Chemo-enzymatic synthesis of a series of 2,4-syn-functionalized (S)-glutamate analogues: new insight into the structure-activity relation of ionotr... J Med Chem. 2008 Jul 24;51(14):4093-103. DMTQF2G RU https://pubmed.ncbi.nlm.nih.gov/18578478 DMGXRSZ DI DMGXRSZ DMGXRSZ DN (2'Z,3'E)-5-Chloro-5'-chloro-indirubin-3'-oxime DMGXRSZ MI TT7HF4W DMGXRSZ MN Cyclin-dependent kinase 2 (CDK2) DMGXRSZ MT DTT DMGXRSZ MA Inhibitor DMGXRSZ RN 5,5'-substituted indirubin-3'-oxime derivatives as potent cyclin-dependent kinase inhibitors with anticancer activity. J Med Chem. 2010 May 13;53(9):3696-706. DMGXRSZ RU https://pubmed.ncbi.nlm.nih.gov/20361800 DMGXRSZ DI DMGXRSZ DMGXRSZ DN (2'Z,3'E)-5-Chloro-5'-chloro-indirubin-3'-oxime DMGXRSZ MI TTCEJ4F DMGXRSZ MN G1/S-specific cyclin-E1 (CCNE1) DMGXRSZ MT DTT DMGXRSZ MA Inhibitor DMGXRSZ RN 5,5'-substituted indirubin-3'-oxime derivatives as potent cyclin-dependent kinase inhibitors with anticancer activity. J Med Chem. 2010 May 13;53(9):3696-706. DMGXRSZ RU https://pubmed.ncbi.nlm.nih.gov/20361800 DM6AUHR DI DM6AUHR DM6AUHR DN (2'Z,3'E)-5-Chloro-5'-fluoro-indirubin-3'-oxime DM6AUHR MI TT7HF4W DM6AUHR MN Cyclin-dependent kinase 2 (CDK2) DM6AUHR MT DTT DM6AUHR MA Inhibitor DM6AUHR RN 5,5'-substituted indirubin-3'-oxime derivatives as potent cyclin-dependent kinase inhibitors with anticancer activity. J Med Chem. 2010 May 13;53(9):3696-706. DM6AUHR RU https://pubmed.ncbi.nlm.nih.gov/20361800 DM6AUHR DI DM6AUHR DM6AUHR DN (2'Z,3'E)-5-Chloro-5'-fluoro-indirubin-3'-oxime DM6AUHR MI TTCEJ4F DM6AUHR MN G1/S-specific cyclin-E1 (CCNE1) DM6AUHR MT DTT DM6AUHR MA Inhibitor DM6AUHR RN 5,5'-substituted indirubin-3'-oxime derivatives as potent cyclin-dependent kinase inhibitors with anticancer activity. J Med Chem. 2010 May 13;53(9):3696-706. DM6AUHR RU https://pubmed.ncbi.nlm.nih.gov/20361800 DMD7WGM DI DMD7WGM DMD7WGM DN (2'Z,3'E)-5-Chloro-5'-hydroxy-indirubin-3'-oxime DMD7WGM MI TT7HF4W DMD7WGM MN Cyclin-dependent kinase 2 (CDK2) DMD7WGM MT DTT DMD7WGM MA Inhibitor DMD7WGM RN 5,5'-substituted indirubin-3'-oxime derivatives as potent cyclin-dependent kinase inhibitors with anticancer activity. J Med Chem. 2010 May 13;53(9):3696-706. DMD7WGM RU https://pubmed.ncbi.nlm.nih.gov/20361800 DMD7WGM DI DMD7WGM DMD7WGM DN (2'Z,3'E)-5-Chloro-5'-hydroxy-indirubin-3'-oxime DMD7WGM MI TTCEJ4F DMD7WGM MN G1/S-specific cyclin-E1 (CCNE1) DMD7WGM MT DTT DMD7WGM MA Inhibitor DMD7WGM RN 5,5'-substituted indirubin-3'-oxime derivatives as potent cyclin-dependent kinase inhibitors with anticancer activity. J Med Chem. 2010 May 13;53(9):3696-706. DMD7WGM RU https://pubmed.ncbi.nlm.nih.gov/20361800 DMZ0V6G DI DMZ0V6G DMZ0V6G DN (2'Z,3'E)-5-Chloro-5'-methyl-indirubin-3'-oxime DMZ0V6G MI TT7HF4W DMZ0V6G MN Cyclin-dependent kinase 2 (CDK2) DMZ0V6G MT DTT DMZ0V6G MA Inhibitor DMZ0V6G RN 5,5'-substituted indirubin-3'-oxime derivatives as potent cyclin-dependent kinase inhibitors with anticancer activity. J Med Chem. 2010 May 13;53(9):3696-706. DMZ0V6G RU https://pubmed.ncbi.nlm.nih.gov/20361800 DMZ0V6G DI DMZ0V6G DMZ0V6G DN (2'Z,3'E)-5-Chloro-5'-methyl-indirubin-3'-oxime DMZ0V6G MI TTCEJ4F DMZ0V6G MN G1/S-specific cyclin-E1 (CCNE1) DMZ0V6G MT DTT DMZ0V6G MA Inhibitor DMZ0V6G RN 5,5'-substituted indirubin-3'-oxime derivatives as potent cyclin-dependent kinase inhibitors with anticancer activity. J Med Chem. 2010 May 13;53(9):3696-706. DMZ0V6G RU https://pubmed.ncbi.nlm.nih.gov/20361800 DMO7RFL DI DMO7RFL DMO7RFL DN (2'Z,3'E)-5-Fluoro-5'-chloro-indirubin-3'-oxime DMO7RFL MI TT7HF4W DMO7RFL MN Cyclin-dependent kinase 2 (CDK2) DMO7RFL MT DTT DMO7RFL MA Inhibitor DMO7RFL RN 5,5'-substituted indirubin-3'-oxime derivatives as potent cyclin-dependent kinase inhibitors with anticancer activity. J Med Chem. 2010 May 13;53(9):3696-706. DMO7RFL RU https://pubmed.ncbi.nlm.nih.gov/20361800 DMO7RFL DI DMO7RFL DMO7RFL DN (2'Z,3'E)-5-Fluoro-5'-chloro-indirubin-3'-oxime DMO7RFL MI TTCEJ4F DMO7RFL MN G1/S-specific cyclin-E1 (CCNE1) DMO7RFL MT DTT DMO7RFL MA Inhibitor DMO7RFL RN 5,5'-substituted indirubin-3'-oxime derivatives as potent cyclin-dependent kinase inhibitors with anticancer activity. J Med Chem. 2010 May 13;53(9):3696-706. DMO7RFL RU https://pubmed.ncbi.nlm.nih.gov/20361800 DMJ4ABD DI DMJ4ABD DMJ4ABD DN (2'Z,3'E)-5-Fluoro-5'-fluoro-indirubin-3'-oxime DMJ4ABD MI TT7HF4W DMJ4ABD MN Cyclin-dependent kinase 2 (CDK2) DMJ4ABD MT DTT DMJ4ABD MA Inhibitor DMJ4ABD RN 5,5'-substituted indirubin-3'-oxime derivatives as potent cyclin-dependent kinase inhibitors with anticancer activity. J Med Chem. 2010 May 13;53(9):3696-706. DMJ4ABD RU https://pubmed.ncbi.nlm.nih.gov/20361800 DMJ4ABD DI DMJ4ABD DMJ4ABD DN (2'Z,3'E)-5-Fluoro-5'-fluoro-indirubin-3'-oxime DMJ4ABD MI TTCEJ4F DMJ4ABD MN G1/S-specific cyclin-E1 (CCNE1) DMJ4ABD MT DTT DMJ4ABD MA Inhibitor DMJ4ABD RN 5,5'-substituted indirubin-3'-oxime derivatives as potent cyclin-dependent kinase inhibitors with anticancer activity. J Med Chem. 2010 May 13;53(9):3696-706. DMJ4ABD RU https://pubmed.ncbi.nlm.nih.gov/20361800 DM9LQH1 DI DM9LQH1 DM9LQH1 DN (2'Z,3'E)-5-Fluoro-5'-hydroxy-indirubin-3'-oxime DM9LQH1 MI TT7HF4W DM9LQH1 MN Cyclin-dependent kinase 2 (CDK2) DM9LQH1 MT DTT DM9LQH1 MA Inhibitor DM9LQH1 RN 5,5'-substituted indirubin-3'-oxime derivatives as potent cyclin-dependent kinase inhibitors with anticancer activity. J Med Chem. 2010 May 13;53(9):3696-706. DM9LQH1 RU https://pubmed.ncbi.nlm.nih.gov/20361800 DM9LQH1 DI DM9LQH1 DM9LQH1 DN (2'Z,3'E)-5-Fluoro-5'-hydroxy-indirubin-3'-oxime DM9LQH1 MI TTCEJ4F DM9LQH1 MN G1/S-specific cyclin-E1 (CCNE1) DM9LQH1 MT DTT DM9LQH1 MA Inhibitor DM9LQH1 RN 5,5'-substituted indirubin-3'-oxime derivatives as potent cyclin-dependent kinase inhibitors with anticancer activity. J Med Chem. 2010 May 13;53(9):3696-706. DM9LQH1 RU https://pubmed.ncbi.nlm.nih.gov/20361800 DMQDH3N DI DMQDH3N DMQDH3N DN (2'Z,3'E)-5-Fluoro-5'-methoxy-indirubin-3'-oxime DMQDH3N MI TT7HF4W DMQDH3N MN Cyclin-dependent kinase 2 (CDK2) DMQDH3N MT DTT DMQDH3N MA Inhibitor DMQDH3N RN 5,5'-substituted indirubin-3'-oxime derivatives as potent cyclin-dependent kinase inhibitors with anticancer activity. J Med Chem. 2010 May 13;53(9):3696-706. DMQDH3N RU https://pubmed.ncbi.nlm.nih.gov/20361800 DMQDH3N DI DMQDH3N DMQDH3N DN (2'Z,3'E)-5-Fluoro-5'-methoxy-indirubin-3'-oxime DMQDH3N MI TTCEJ4F DMQDH3N MN G1/S-specific cyclin-E1 (CCNE1) DMQDH3N MT DTT DMQDH3N MA Inhibitor DMQDH3N RN 5,5'-substituted indirubin-3'-oxime derivatives as potent cyclin-dependent kinase inhibitors with anticancer activity. J Med Chem. 2010 May 13;53(9):3696-706. DMQDH3N RU https://pubmed.ncbi.nlm.nih.gov/20361800 DMAS3JC DI DMAS3JC DMAS3JC DN (2'Z,3'E)-5-Fluoro-5'-methyl-indirubin-3'-oxime DMAS3JC MI TT7HF4W DMAS3JC MN Cyclin-dependent kinase 2 (CDK2) DMAS3JC MT DTT DMAS3JC MA Inhibitor DMAS3JC RN 5,5'-substituted indirubin-3'-oxime derivatives as potent cyclin-dependent kinase inhibitors with anticancer activity. J Med Chem. 2010 May 13;53(9):3696-706. DMAS3JC RU https://pubmed.ncbi.nlm.nih.gov/20361800 DMAS3JC DI DMAS3JC DMAS3JC DN (2'Z,3'E)-5-Fluoro-5'-methyl-indirubin-3'-oxime DMAS3JC MI TTCEJ4F DMAS3JC MN G1/S-specific cyclin-E1 (CCNE1) DMAS3JC MT DTT DMAS3JC MA Inhibitor DMAS3JC RN 5,5'-substituted indirubin-3'-oxime derivatives as potent cyclin-dependent kinase inhibitors with anticancer activity. J Med Chem. 2010 May 13;53(9):3696-706. DMAS3JC RU https://pubmed.ncbi.nlm.nih.gov/20361800 DMYLX0U DI DMYLX0U DMYLX0U DN (2'Z,3'E)-5-Nitro-5'-chloro-indirubin-3'-oxime DMYLX0U MI TT7HF4W DMYLX0U MN Cyclin-dependent kinase 2 (CDK2) DMYLX0U MT DTT DMYLX0U MA Inhibitor DMYLX0U RN 5,5'-substituted indirubin-3'-oxime derivatives as potent cyclin-dependent kinase inhibitors with anticancer activity. J Med Chem. 2010 May 13;53(9):3696-706. DMYLX0U RU https://pubmed.ncbi.nlm.nih.gov/20361800 DMYLX0U DI DMYLX0U DMYLX0U DN (2'Z,3'E)-5-Nitro-5'-chloro-indirubin-3'-oxime DMYLX0U MI TTCEJ4F DMYLX0U MN G1/S-specific cyclin-E1 (CCNE1) DMYLX0U MT DTT DMYLX0U MA Inhibitor DMYLX0U RN 5,5'-substituted indirubin-3'-oxime derivatives as potent cyclin-dependent kinase inhibitors with anticancer activity. J Med Chem. 2010 May 13;53(9):3696-706. DMYLX0U RU https://pubmed.ncbi.nlm.nih.gov/20361800 DMXZ2UC DI DMXZ2UC DMXZ2UC DN (2'Z,3'E)-5-Nitro-5'-fluoro-indirubin-3'-oxime DMXZ2UC MI TT7HF4W DMXZ2UC MN Cyclin-dependent kinase 2 (CDK2) DMXZ2UC MT DTT DMXZ2UC MA Inhibitor DMXZ2UC RN 5,5'-substituted indirubin-3'-oxime derivatives as potent cyclin-dependent kinase inhibitors with anticancer activity. J Med Chem. 2010 May 13;53(9):3696-706. DMXZ2UC RU https://pubmed.ncbi.nlm.nih.gov/20361800 DMXZ2UC DI DMXZ2UC DMXZ2UC DN (2'Z,3'E)-5-Nitro-5'-fluoro-indirubin-3'-oxime DMXZ2UC MI TTCEJ4F DMXZ2UC MN G1/S-specific cyclin-E1 (CCNE1) DMXZ2UC MT DTT DMXZ2UC MA Inhibitor DMXZ2UC RN 5,5'-substituted indirubin-3'-oxime derivatives as potent cyclin-dependent kinase inhibitors with anticancer activity. J Med Chem. 2010 May 13;53(9):3696-706. DMXZ2UC RU https://pubmed.ncbi.nlm.nih.gov/20361800 DM0S82C DI DM0S82C DM0S82C DN (2'Z,3'E)-5-Nitro-5'-hydroxy-indirubin-3'-oxime DM0S82C MI TT7HF4W DM0S82C MN Cyclin-dependent kinase 2 (CDK2) DM0S82C MT DTT DM0S82C MA Inhibitor DM0S82C RN 5,5'-substituted indirubin-3'-oxime derivatives as potent cyclin-dependent kinase inhibitors with anticancer activity. J Med Chem. 2010 May 13;53(9):3696-706. DM0S82C RU https://pubmed.ncbi.nlm.nih.gov/20361800 DM0S82C DI DM0S82C DM0S82C DN (2'Z,3'E)-5-Nitro-5'-hydroxy-indirubin-3'-oxime DM0S82C MI TTCEJ4F DM0S82C MN G1/S-specific cyclin-E1 (CCNE1) DM0S82C MT DTT DM0S82C MA Inhibitor DM0S82C RN 5,5'-substituted indirubin-3'-oxime derivatives as potent cyclin-dependent kinase inhibitors with anticancer activity. J Med Chem. 2010 May 13;53(9):3696-706. DM0S82C RU https://pubmed.ncbi.nlm.nih.gov/20361800 DMLOIUK DI DMLOIUK DMLOIUK DN (2'Z,3'E)-5-Nitro-5'-methoxy-indirubin-3'-oxime DMLOIUK MI TT7HF4W DMLOIUK MN Cyclin-dependent kinase 2 (CDK2) DMLOIUK MT DTT DMLOIUK MA Inhibitor DMLOIUK RN 5,5'-substituted indirubin-3'-oxime derivatives as potent cyclin-dependent kinase inhibitors with anticancer activity. J Med Chem. 2010 May 13;53(9):3696-706. DMLOIUK RU https://pubmed.ncbi.nlm.nih.gov/20361800 DMLOIUK DI DMLOIUK DMLOIUK DN (2'Z,3'E)-5-Nitro-5'-methoxy-indirubin-3'-oxime DMLOIUK MI TTCEJ4F DMLOIUK MN G1/S-specific cyclin-E1 (CCNE1) DMLOIUK MT DTT DMLOIUK MA Inhibitor DMLOIUK RN 5,5'-substituted indirubin-3'-oxime derivatives as potent cyclin-dependent kinase inhibitors with anticancer activity. J Med Chem. 2010 May 13;53(9):3696-706. DMLOIUK RU https://pubmed.ncbi.nlm.nih.gov/20361800 DM6BA5L DI DM6BA5L DM6BA5L DN (2'Z,3'E)-5-Nitro-5'-methyl-indirubin-3'-oxime DM6BA5L MI TT7HF4W DM6BA5L MN Cyclin-dependent kinase 2 (CDK2) DM6BA5L MT DTT DM6BA5L MA Inhibitor DM6BA5L RN 5,5'-substituted indirubin-3'-oxime derivatives as potent cyclin-dependent kinase inhibitors with anticancer activity. J Med Chem. 2010 May 13;53(9):3696-706. DM6BA5L RU https://pubmed.ncbi.nlm.nih.gov/20361800 DM6BA5L DI DM6BA5L DM6BA5L DN (2'Z,3'E)-5-Nitro-5'-methyl-indirubin-3'-oxime DM6BA5L MI TTCEJ4F DM6BA5L MN G1/S-specific cyclin-E1 (CCNE1) DM6BA5L MT DTT DM6BA5L MA Inhibitor DM6BA5L RN 5,5'-substituted indirubin-3'-oxime derivatives as potent cyclin-dependent kinase inhibitors with anticancer activity. J Med Chem. 2010 May 13;53(9):3696-706. DM6BA5L RU https://pubmed.ncbi.nlm.nih.gov/20361800 DMUIOAP DI DMUIOAP DMUIOAP DN (2'Z,3'E)-7-Azaindirubin-3'-oxime DMUIOAP MI TTRSMW9 DMUIOAP MN Glycogen synthase kinase-3 beta (GSK-3B) DMUIOAP MT DTT DMUIOAP MA Inhibitor DMUIOAP RN Synthesis and antiproliferative activity of 7-azaindirubin-3'-oxime, a 7-aza isostere of the natural indirubin pharmacophore. J Nat Prod. 2009 Dec;72(12):2199-202. DMUIOAP RU https://pubmed.ncbi.nlm.nih.gov/19994845 DMBZJT5 DI DMBZJT5 DMBZJT5 DN (3-((1H-imidazol-1-yl)methyl)phenyl)methanol DMBZJT5 MI TTIQUX7 DMBZJT5 MN Steroid 11-beta-hydroxylase (CYP11B1) DMBZJT5 MT DTT DMBZJT5 MA Inhibitor DMBZJT5 RN Synthesis, biological evaluation, and molecular modeling of 1-benzyl-1H-imidazoles as selective inhibitors of aldosterone synthase (CYP11B2). J Med Chem. 2010 Feb 25;53(4):1712-25. DMBZJT5 RU https://pubmed.ncbi.nlm.nih.gov/20121113 DMR6JTQ DI DMR6JTQ DMR6JTQ DN (3-(2-methylquinolin-7-yl)phenyl)methanol DMR6JTQ MI TTHS256 DMR6JTQ MN Metabotropic glutamate receptor 5 (mGluR5) DMR6JTQ MT DTT DMR6JTQ MA Inhibitor DMR6JTQ RN Rational design of 7-arylquinolines as non-competitive metabotropic glutamate receptor subtype 5 antagonists. Bioorg Med Chem Lett. 2007 Aug 15;17(16):4415-8. DMR6JTQ RU https://pubmed.ncbi.nlm.nih.gov/17590335 DMNVDLI DI DMNVDLI DMNVDLI DN (3,4-dichlorophenyl)(1H-pyrazol-1-yl)methanone DMNVDLI MI TT6L509 DMNVDLI MN Coagulation factor IIa (F2) DMNVDLI MT DTT DMNVDLI MA Inhibitor DMNVDLI RN N-benzoylpyrazoles are novel small-molecule inhibitors of human neutrophil elastase. J Med Chem. 2007 Oct 4;50(20):4928-38. DMNVDLI RU https://pubmed.ncbi.nlm.nih.gov/17850059 DMNVDLI DI DMNVDLI DMNVDLI DN (3,4-dichlorophenyl)(1H-pyrazol-1-yl)methanone DMNVDLI MI TTPLTSQ DMNVDLI MN Neutrophil elastase (NE) DMNVDLI MT DTT DMNVDLI MA Inhibitor DMNVDLI RN N-benzoylpyrazoles are novel small-molecule inhibitors of human neutrophil elastase. J Med Chem. 2007 Oct 4;50(20):4928-38. DMNVDLI RU https://pubmed.ncbi.nlm.nih.gov/17850059 DMNVDLI DI DMNVDLI DMNVDLI DN (3,4-dichlorophenyl)(1H-pyrazol-1-yl)methanone DMNVDLI MI TTMF8H9 DMNVDLI MN Plasma kallikrein (KLKB1) DMNVDLI MT DTT DMNVDLI MA Inhibitor DMNVDLI RN N-benzoylpyrazoles are novel small-molecule inhibitors of human neutrophil elastase. J Med Chem. 2007 Oct 4;50(20):4928-38. DMNVDLI RU https://pubmed.ncbi.nlm.nih.gov/17850059 DMNVDLI DI DMNVDLI DMNVDLI DN (3,4-dichlorophenyl)(1H-pyrazol-1-yl)methanone DMNVDLI MI TTGY7WI DMNVDLI MN Urokinase-type plasminogen activator (PLAU) DMNVDLI MT DTT DMNVDLI MA Inhibitor DMNVDLI RN N-benzoylpyrazoles are novel small-molecule inhibitors of human neutrophil elastase. J Med Chem. 2007 Oct 4;50(20):4928-38. DMNVDLI RU https://pubmed.ncbi.nlm.nih.gov/17850059 DMTB41W DI DMTB41W DMTB41W DN (3,4-DIHYDROXY-2-NITROPHENYL)(PHENYL)METHANONE DMTB41W MI TTKWFB8 DMTB41W MN Catechol-O-methyl-transferase (COMT) DMTB41W MT DTT DMTB41W MA Inhibitor DMTB41W RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DMTB41W RU https://pubmed.ncbi.nlm.nih.gov/10592235 DMAF43E DI DMAF43E DMAF43E DN (3,4-dimethylphenyl)(4-phenoxyphenyl)methanone DMAF43E MI TTVBPDM DMAF43E MN Metabotropic glutamate receptor 1 (mGluR1) DMAF43E MT DTT DMAF43E MA Inhibitor DMAF43E RN Synergism of virtual screening and medicinal chemistry: identification and optimization of allosteric antagonists of metabotropic glutamate recepto... Bioorg Med Chem. 2009 Aug 1;17(15):5708-15. DMAF43E RU https://pubmed.ncbi.nlm.nih.gov/19574055 DM9PDCA DI DM9PDCA DM9PDCA DN (3,5-Dibromo-4-butoxy-phenyl)-acetic acid DM9PDCA MI TTGER3L DM9PDCA MN Thyroid hormone receptor beta (THRB) DM9PDCA MT DTT DM9PDCA MA Inhibitor DM9PDCA RN Thyroid receptor ligands. 3. Design and synthesis of 3,5-dihalo-4-alkoxyphenylalkanoic acids as indirect antagonists of the thyroid hormone receptor. J Med Chem. 2005 May 5;48(9):3114-7. DM9PDCA RU https://pubmed.ncbi.nlm.nih.gov/15857115 DM5GN46 DI DM5GN46 DM5GN46 DN (3,5-Dibromo-4-hexyloxy-phenyl)-acetic acid DM5GN46 MI TTTSEPU DM5GN46 MN Thyroid hormone receptor alpha (THRA) DM5GN46 MT DTT DM5GN46 MA Inhibitor DM5GN46 RN Thyroid receptor ligands. 3. Design and synthesis of 3,5-dihalo-4-alkoxyphenylalkanoic acids as indirect antagonists of the thyroid hormone receptor. J Med Chem. 2005 May 5;48(9):3114-7. DM5GN46 RU https://pubmed.ncbi.nlm.nih.gov/15857115 DM5GN46 DI DM5GN46 DM5GN46 DN (3,5-Dibromo-4-hexyloxy-phenyl)-acetic acid DM5GN46 MI TTGER3L DM5GN46 MN Thyroid hormone receptor beta (THRB) DM5GN46 MT DTT DM5GN46 MA Inhibitor DM5GN46 RN Thyroid receptor ligands. 3. Design and synthesis of 3,5-dihalo-4-alkoxyphenylalkanoic acids as indirect antagonists of the thyroid hormone receptor. J Med Chem. 2005 May 5;48(9):3114-7. DM5GN46 RU https://pubmed.ncbi.nlm.nih.gov/15857115 DMB5KVZ DI DMB5KVZ DMB5KVZ DN (3,5-Dibromo-4-pentyloxy-phenyl)-acetic acid DMB5KVZ MI TTGER3L DMB5KVZ MN Thyroid hormone receptor beta (THRB) DMB5KVZ MT DTT DMB5KVZ MA Inhibitor DMB5KVZ RN Thyroid receptor ligands. 3. Design and synthesis of 3,5-dihalo-4-alkoxyphenylalkanoic acids as indirect antagonists of the thyroid hormone receptor. J Med Chem. 2005 May 5;48(9):3114-7. DMB5KVZ RU https://pubmed.ncbi.nlm.nih.gov/15857115 DM3OPNE DI DM3OPNE DM3OPNE DN (35)S-labeled oligonucleotide DM3OPNE MI TTSXP1G DM3OPNE MN Protein kinase A alpha messenger RNA (PKA-alpha mRNA) DM3OPNE MT DTT DM3OPNE RN Antitumor activity and pharmacokinetics of a mixed-backbone antisense oligonucleotide targeted to the RIalpha subunit of protein kinase A after oral administration. Proc Natl Acad Sci U S A. 1999 Nov23;96(24):13989-94. DM3OPNE RU https://pubmed.ncbi.nlm.nih.gov/10570186 DM3OPNE DI DM3OPNE DM3OPNE DN (35)S-labeled oligonucleotide DM3OPNE MI TTXQFV2 DM3OPNE MN Protein kinase A Ri alpha messenger RNA (PKA-Ri-alpha mRNA) DM3OPNE MT DTT DM3OPNE RN Antitumor activity and pharmacokinetics of a mixed-backbone antisense oligonucleotide targeted to the RIalpha subunit of protein kinase A after oral administration. Proc Natl Acad Sci U S A. 1999 Nov23;96(24):13989-94. DM3OPNE RU https://pubmed.ncbi.nlm.nih.gov/10570186 DMPHCX7 DI DMPHCX7 DMPHCX7 DN (3-Amino-1-ethyl-propyl)-methyl-phosphinic acid DMPHCX7 MI TTDCVZW DMPHCX7 MN Gamma-aminobutyric acid B receptor (GABBR) DMPHCX7 MT DTT DMPHCX7 MA Inhibitor DMPHCX7 RN Phosphinic acid analogues of GABA. 1. New potent and selective GABAB agonists. J Med Chem. 1995 Aug 18;38(17):3297-312. DMPHCX7 RU https://pubmed.ncbi.nlm.nih.gov/7650684 DM7HF4I DI DM7HF4I DM7HF4I DN (3-Amino-1-hydroxy-propyl)-methyl-phosphinic acid DM7HF4I MI TTDCVZW DM7HF4I MN Gamma-aminobutyric acid B receptor (GABBR) DM7HF4I MT DTT DM7HF4I MA Inhibitor DM7HF4I RN Phosphinic acid analogues of GABA. 1. New potent and selective GABAB agonists. J Med Chem. 1995 Aug 18;38(17):3297-312. DM7HF4I RU https://pubmed.ncbi.nlm.nih.gov/7650684 DMP2G5W DI DMP2G5W DMP2G5W DN (3-amino-5-bromobenzofuran-2-yl)(phenyl)methanone DMP2G5W MI TTM2AOE DMP2G5W MN Adenosine A2a receptor (ADORA2A) DMP2G5W MT DTT DMP2G5W MA Inhibitor DMP2G5W RN Structure-based discovery of novel chemotypes for adenosine A(2A) receptor antagonists. J Med Chem. 2010 Feb 25;53(4):1799-809. DMP2G5W RU https://pubmed.ncbi.nlm.nih.gov/20095623 DMDGFS0 DI DMDGFS0 DMDGFS0 DN (3-Amino-phenyl)-phosphonic acid diphenyl ester DMDGFS0 MI TTDCVZW DMDGFS0 MN Gamma-aminobutyric acid B receptor (GABBR) DMDGFS0 MT DTT DMDGFS0 MA Inhibitor DMDGFS0 RN Phosphorus analogues of gamma-aminobutyric acid, a new class of anticonvulsants. J Med Chem. 1984 May;27(5):654-9. DMDGFS0 RU https://pubmed.ncbi.nlm.nih.gov/6325692 DMBJYTD DI DMBJYTD DMBJYTD DN (3-Amino-propyl)-hexyl-phosphinic acid DMBJYTD MI TTDCVZW DMBJYTD MN Gamma-aminobutyric acid B receptor (GABBR) DMBJYTD MT DTT DMBJYTD MA Inhibitor DMBJYTD RN Biological activity of 3-aminopropyl (methyl) phosphinic acid, a potent and selective GABAB agonist with CNS activity, Bioorg. Med. Chem. Lett. 3(4):515-518 (1993). DMBJYTD RU http://www.sciencedirect.com/science/article/pii/S0960894X0181218X DMGFIJV DI DMGFIJV DMGFIJV DN (3-Amino-propyl)-hydroxymethyl-phosphinic acid DMGFIJV MI TTDCVZW DMGFIJV MN Gamma-aminobutyric acid B receptor (GABBR) DMGFIJV MT DTT DMGFIJV MA Inhibitor DMGFIJV RN Phosphinic acid analogues of GABA. 1. New potent and selective GABAB agonists. J Med Chem. 1995 Aug 18;38(17):3297-312. DMGFIJV RU https://pubmed.ncbi.nlm.nih.gov/7650684 DMK3JZS DI DMK3JZS DMK3JZS DN (3-Amino-propyl)-phosphonic acid DMK3JZS MI TTDCVZW DMK3JZS MN Gamma-aminobutyric acid B receptor (GABBR) DMK3JZS MT DTT DMK3JZS MA Inhibitor DMK3JZS RN Phosphorus analogues of gamma-aminobutyric acid, a new class of anticonvulsants. J Med Chem. 1984 May;27(5):654-9. DMK3JZS RU https://pubmed.ncbi.nlm.nih.gov/6325692 DMHF01G DI DMHF01G DMHF01G DN (3-Bromobenzoylpyridine)thiosemicarbazone DMHF01G MI TT36ETB DMHF01G MN Cathepsin L (CTSL) DMHF01G MT DTT DMHF01G MA Inhibitor DMHF01G RN Functionalized benzophenone, thiophene, pyridine, and fluorene thiosemicarbazone derivatives as inhibitors of cathepsin L. Bioorg Med Chem Lett. 2010 Nov 15;20(22):6610-5. DMHF01G RU https://pubmed.ncbi.nlm.nih.gov/20933415 DMIJH7W DI DMIJH7W DMIJH7W DN (3-bromophenyl)(10H-phenothiazin-10-yl)methanone DMIJH7W MI TTEB0GD DMIJH7W MN Cholinesterase (BCHE) DMIJH7W MT DTT DMIJH7W MA Inhibitor DMIJH7W RN Selective reversible inhibition of human butyrylcholinesterase by aryl amide derivatives of phenothiazine. Bioorg Med Chem. 2007 Oct 1;15(19):6367-78. DMIJH7W RU https://pubmed.ncbi.nlm.nih.gov/17681768 DMHLF2S DI DMHLF2S DMHLF2S DN (3-Bromo-phenyl)-(5-nitro-quinazolin-4-yl)-amine DMHLF2S MI TTGKNB4 DMHLF2S MN Epidermal growth factor receptor (EGFR) DMHLF2S MT DTT DMHLF2S MA Inhibitor DMHLF2S RN Tyrosine kinase inhibitors. 5. Synthesis and structure-activity relationships for 4-[(phenylmethyl)amino]- and 4-(phenylamino)quinazolines as poten... J Med Chem. 1995 Sep 1;38(18):3482-7. DMHLF2S RU https://pubmed.ncbi.nlm.nih.gov/7658435 DMMIPZ8 DI DMMIPZ8 DMMIPZ8 DN (3-Bromo-phenyl)-quinazolin-4-yl-amine DMMIPZ8 MI TTGKNB4 DMMIPZ8 MN Epidermal growth factor receptor (EGFR) DMMIPZ8 MT DTT DMMIPZ8 MA Inhibitor DMMIPZ8 RN Tyrosine kinase inhibitors. 9. Synthesis and evaluation of fused tricyclic quinazoline analogues as ATP site inhibitors of the tyrosine kinase acti... J Med Chem. 1996 Feb 16;39(4):918-28. DMMIPZ8 RU https://pubmed.ncbi.nlm.nih.gov/8632415 DMUJ18K DI DMUJ18K DMUJ18K DN (3-Bromo-propyl)-trimethyl-ammonium DMUJ18K MI TT1RS9F DMUJ18K MN Acetylcholinesterase (AChE) DMUJ18K MT DTT DMUJ18K MA Inhibitor DMUJ18K RN Structure-based alignment and comparative molecular field analysis of acetylcholinesterase inhibitors. J Med Chem. 1996 Dec 20;39(26):5064-71. DMUJ18K RU https://pubmed.ncbi.nlm.nih.gov/8978837 DMHODXG DI DMHODXG DMHODXG DN (3-Chloro-4-Propoxy-Phenyl)-Acetic Acid DMHODXG MI TT8NGED DMHODXG MN Prostaglandin G/H synthase 1 (COX-1) DMHODXG MT DTT DMHODXG MA Inhibitor DMHODXG RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DMHODXG RU https://pubmed.ncbi.nlm.nih.gov/10592235 DM7U02R DI DM7U02R DM7U02R DN (3-Chloro-phenyl)-piperazin-1-yl-methanone DM7U02R MI TTSQIFT DM7U02R MN 5-HT 1A receptor (HTR1A) DM7U02R MT DTT DM7U02R MA Inhibitor DM7U02R RN Synthesis and evaluation of phenyl- and benzoylpiperazines as potential serotonergic agents. J Med Chem. 1986 May;29(5):630-4. DM7U02R RU https://pubmed.ncbi.nlm.nih.gov/3701781 DM7U02R DI DM7U02R DM7U02R DN (3-Chloro-phenyl)-piperazin-1-yl-methanone DM7U02R MI TT6MSOK DM7U02R MN 5-HT 1D receptor (HTR1D) DM7U02R MT DTT DM7U02R MA Inhibitor DM7U02R RN Synthesis and evaluation of phenyl- and benzoylpiperazines as potential serotonergic agents. J Med Chem. 1986 May;29(5):630-4. DM7U02R RU https://pubmed.ncbi.nlm.nih.gov/3701781 DMG1KIJ DI DMG1KIJ DMG1KIJ DN (3-Ethoxy-pyridin-2-yl)-pyridin-2-yl-amine DMG1KIJ MI TTHS256 DMG1KIJ MN Metabotropic glutamate receptor 5 (mGluR5) DMG1KIJ MT DTT DMG1KIJ MA Inhibitor DMG1KIJ RN Dipyridyl amines: potent metabotropic glutamate subtype 5 receptor antagonists. Bioorg Med Chem Lett. 2005 Oct 1;15(19):4350-3. DMG1KIJ RU https://pubmed.ncbi.nlm.nih.gov/16039855 DM5WJBH DI DM5WJBH DM5WJBH DN (3-Ethyl-indol-1-yl)-propyl-pyridin-4-yl-amine DM5WJBH MI TTWG9A4 DM5WJBH MN Adrenergic receptor alpha-2A (ADRA2A) DM5WJBH MT DTT DM5WJBH MA Inhibitor DM5WJBH RN Synthesis and structure-activity relationships of N-propyl-N-(4-pyridinyl)-1H-indol-1-amine (besipirdine) and related analogs as potential therapeu... J Med Chem. 1996 Jan 19;39(2):570-81. DM5WJBH RU https://pubmed.ncbi.nlm.nih.gov/8558529 DM5WJBH DI DM5WJBH DM5WJBH DN (3-Ethyl-indol-1-yl)-propyl-pyridin-4-yl-amine DM5WJBH MI TTWM4TY DM5WJBH MN Adrenergic receptor alpha-2B (ADRA2B) DM5WJBH MT DTT DM5WJBH MA Inhibitor DM5WJBH RN Synthesis and structure-activity relationships of N-propyl-N-(4-pyridinyl)-1H-indol-1-amine (besipirdine) and related analogs as potential therapeu... J Med Chem. 1996 Jan 19;39(2):570-81. DM5WJBH RU https://pubmed.ncbi.nlm.nih.gov/8558529 DM5WJBH DI DM5WJBH DM5WJBH DN (3-Ethyl-indol-1-yl)-propyl-pyridin-4-yl-amine DM5WJBH MI TT2NUT5 DM5WJBH MN Adrenergic receptor alpha-2C (ADRA2C) DM5WJBH MT DTT DM5WJBH MA Inhibitor DM5WJBH RN Synthesis and structure-activity relationships of N-propyl-N-(4-pyridinyl)-1H-indol-1-amine (besipirdine) and related analogs as potential therapeu... J Med Chem. 1996 Jan 19;39(2):570-81. DM5WJBH RU https://pubmed.ncbi.nlm.nih.gov/8558529 DMPHM23 DI DMPHM23 DMPHM23 DN (3-fluoro-4-(4-phenoxybenzoyl)phenyl)acetic acid DMPHM23 MI TTTU72V DMPHM23 MN Steroid 5-alpha-reductase 1 (SRD5A1) DMPHM23 MT DTT DMPHM23 MA Inhibitor DMPHM23 RN Novel 5alpha-reductase inhibitors: synthesis, structure-activity studies, and pharmacokinetic profile of phenoxybenzoylphenyl acetic acids. J Med Chem. 2006 Jan 26;49(2):748-59. DMPHM23 RU https://pubmed.ncbi.nlm.nih.gov/16420060 DMPHM23 DI DMPHM23 DMPHM23 DN (3-fluoro-4-(4-phenoxybenzoyl)phenyl)acetic acid DMPHM23 MI TTT02K8 DMPHM23 MN Steroid 5-alpha-reductase 2 (SRD5A2) DMPHM23 MT DTT DMPHM23 MA Inhibitor DMPHM23 RN Novel 5alpha-reductase inhibitors: synthesis, structure-activity studies, and pharmacokinetic profile of phenoxybenzoylphenyl acetic acids. J Med Chem. 2006 Jan 26;49(2):748-59. DMPHM23 RU https://pubmed.ncbi.nlm.nih.gov/16420060 DM08UQF DI DM08UQF DM08UQF DN (3-Hydroxy-2-methyl-phenyl)-trimethyl-ammonium DM08UQF MI TT1RS9F DM08UQF MN Acetylcholinesterase (AChE) DM08UQF MT DTT DM08UQF MA Inhibitor DM08UQF RN Structure-based alignment and comparative molecular field analysis of acetylcholinesterase inhibitors. J Med Chem. 1996 Dec 20;39(26):5064-71. DM08UQF RU https://pubmed.ncbi.nlm.nih.gov/8978837 DMX5CY3 DI DMX5CY3 DMX5CY3 DN (3-methyl-4-(4-phenoxybenzoyl)phenyl)acetic acid DMX5CY3 MI TTTU72V DMX5CY3 MN Steroid 5-alpha-reductase 1 (SRD5A1) DMX5CY3 MT DTT DMX5CY3 MA Inhibitor DMX5CY3 RN Novel 5alpha-reductase inhibitors: synthesis, structure-activity studies, and pharmacokinetic profile of phenoxybenzoylphenyl acetic acids. J Med Chem. 2006 Jan 26;49(2):748-59. DMX5CY3 RU https://pubmed.ncbi.nlm.nih.gov/16420060 DMX5CY3 DI DMX5CY3 DMX5CY3 DN (3-methyl-4-(4-phenoxybenzoyl)phenyl)acetic acid DMX5CY3 MI TTT02K8 DMX5CY3 MN Steroid 5-alpha-reductase 2 (SRD5A2) DMX5CY3 MT DTT DMX5CY3 MA Inhibitor DMX5CY3 RN Novel 5alpha-reductase inhibitors: synthesis, structure-activity studies, and pharmacokinetic profile of phenoxybenzoylphenyl acetic acids. J Med Chem. 2006 Jan 26;49(2):748-59. DMX5CY3 RU https://pubmed.ncbi.nlm.nih.gov/16420060 DMHED9G DI DMHED9G DMHED9G DN (3-Methyl-indol-1-yl)-propyl-pyridin-4-yl-amine DMHED9G MI TTWG9A4 DMHED9G MN Adrenergic receptor alpha-2A (ADRA2A) DMHED9G MT DTT DMHED9G MA Inhibitor DMHED9G RN Synthesis and structure-activity relationships of N-propyl-N-(4-pyridinyl)-1H-indol-1-amine (besipirdine) and related analogs as potential therapeu... J Med Chem. 1996 Jan 19;39(2):570-81. DMHED9G RU https://pubmed.ncbi.nlm.nih.gov/8558529 DMHED9G DI DMHED9G DMHED9G DN (3-Methyl-indol-1-yl)-propyl-pyridin-4-yl-amine DMHED9G MI TTWM4TY DMHED9G MN Adrenergic receptor alpha-2B (ADRA2B) DMHED9G MT DTT DMHED9G MA Inhibitor DMHED9G RN Synthesis and structure-activity relationships of N-propyl-N-(4-pyridinyl)-1H-indol-1-amine (besipirdine) and related analogs as potential therapeu... J Med Chem. 1996 Jan 19;39(2):570-81. DMHED9G RU https://pubmed.ncbi.nlm.nih.gov/8558529 DMHED9G DI DMHED9G DMHED9G DN (3-Methyl-indol-1-yl)-propyl-pyridin-4-yl-amine DMHED9G MI TT2NUT5 DMHED9G MN Adrenergic receptor alpha-2C (ADRA2C) DMHED9G MT DTT DMHED9G MA Inhibitor DMHED9G RN Synthesis and structure-activity relationships of N-propyl-N-(4-pyridinyl)-1H-indol-1-amine (besipirdine) and related analogs as potential therapeu... J Med Chem. 1996 Jan 19;39(2):570-81. DMHED9G RU https://pubmed.ncbi.nlm.nih.gov/8558529 DMD4Z6H DI DMD4Z6H DMD4Z6H DN (3-nitro-1H-pyrazol-1-yl)(phenyl)methanone DMD4Z6H MI TT6L509 DMD4Z6H MN Coagulation factor IIa (F2) DMD4Z6H MT DTT DMD4Z6H MA Inhibitor DMD4Z6H RN N-benzoylpyrazoles are novel small-molecule inhibitors of human neutrophil elastase. J Med Chem. 2007 Oct 4;50(20):4928-38. DMD4Z6H RU https://pubmed.ncbi.nlm.nih.gov/17850059 DMD4Z6H DI DMD4Z6H DMD4Z6H DN (3-nitro-1H-pyrazol-1-yl)(phenyl)methanone DMD4Z6H MI TTPLTSQ DMD4Z6H MN Neutrophil elastase (NE) DMD4Z6H MT DTT DMD4Z6H MA Inhibitor DMD4Z6H RN N-benzoylpyrazoles are novel small-molecule inhibitors of human neutrophil elastase. J Med Chem. 2007 Oct 4;50(20):4928-38. DMD4Z6H RU https://pubmed.ncbi.nlm.nih.gov/17850059 DMD4Z6H DI DMD4Z6H DMD4Z6H DN (3-nitro-1H-pyrazol-1-yl)(phenyl)methanone DMD4Z6H MI TTMF8H9 DMD4Z6H MN Plasma kallikrein (KLKB1) DMD4Z6H MT DTT DMD4Z6H MA Inhibitor DMD4Z6H RN N-benzoylpyrazoles are novel small-molecule inhibitors of human neutrophil elastase. J Med Chem. 2007 Oct 4;50(20):4928-38. DMD4Z6H RU https://pubmed.ncbi.nlm.nih.gov/17850059 DMT9FZD DI DMT9FZD DMT9FZD DN (3-nitro-1H-pyrazol-1-yl)(p-tolyl)methanone DMT9FZD MI TT6L509 DMT9FZD MN Coagulation factor IIa (F2) DMT9FZD MT DTT DMT9FZD MA Inhibitor DMT9FZD RN N-benzoylpyrazoles are novel small-molecule inhibitors of human neutrophil elastase. J Med Chem. 2007 Oct 4;50(20):4928-38. DMT9FZD RU https://pubmed.ncbi.nlm.nih.gov/17850059 DMT9FZD DI DMT9FZD DMT9FZD DN (3-nitro-1H-pyrazol-1-yl)(p-tolyl)methanone DMT9FZD MI TTPLTSQ DMT9FZD MN Neutrophil elastase (NE) DMT9FZD MT DTT DMT9FZD MA Inhibitor DMT9FZD RN N-benzoylpyrazoles are novel small-molecule inhibitors of human neutrophil elastase. J Med Chem. 2007 Oct 4;50(20):4928-38. DMT9FZD RU https://pubmed.ncbi.nlm.nih.gov/17850059 DMT9FZD DI DMT9FZD DMT9FZD DN (3-nitro-1H-pyrazol-1-yl)(p-tolyl)methanone DMT9FZD MI TTMF8H9 DMT9FZD MN Plasma kallikrein (KLKB1) DMT9FZD MT DTT DMT9FZD MA Inhibitor DMT9FZD RN N-benzoylpyrazoles are novel small-molecule inhibitors of human neutrophil elastase. J Med Chem. 2007 Oct 4;50(20):4928-38. DMT9FZD RU https://pubmed.ncbi.nlm.nih.gov/17850059 DMT9FZD DI DMT9FZD DMT9FZD DN (3-nitro-1H-pyrazol-1-yl)(p-tolyl)methanone DMT9FZD MI TTGY7WI DMT9FZD MN Urokinase-type plasminogen activator (PLAU) DMT9FZD MT DTT DMT9FZD MA Inhibitor DMT9FZD RN N-benzoylpyrazoles are novel small-molecule inhibitors of human neutrophil elastase. J Med Chem. 2007 Oct 4;50(20):4928-38. DMT9FZD RU https://pubmed.ncbi.nlm.nih.gov/17850059 DMGYAP7 DI DMGYAP7 DMGYAP7 DN (3-Phenoxy-phenyl)-(5-phenyl-oxazol-2-yl)-amine DMGYAP7 MI TTUTJGQ DMGYAP7 MN Vascular endothelial growth factor receptor 2 (KDR) DMGYAP7 MT DTT DMGYAP7 MA Inhibitor DMGYAP7 RN Discovery and evaluation of 2-anilino-5-aryloxazoles as a novel class of VEGFR2 kinase inhibitors. J Med Chem. 2005 Mar 10;48(5):1610-9. DMGYAP7 RU https://pubmed.ncbi.nlm.nih.gov/15743202 DM1C90Y DI DM1C90Y DM1C90Y DN (3-Phenyl-propyl)-quinazolin-4-yl-amine DM1C90Y MI TT64EPS DM1C90Y MN Fungal Scytalone dehydratase (Fung SDH1) DM1C90Y MT DTT DM1C90Y MA Inhibitor DM1C90Y RN A diazine heterocycle replaces a six-membered hydrogen-bonded array in the active site of scytalone dehydratase, Bioorg. Med. Chem. Lett. 3(8):1605-1608 (1993). DM1C90Y RU http://www.sciencedirect.com/science/article/pii/S0960894X00800268 DM49YTN DI DM49YTN DM49YTN DN (3r)-1-Acetyl-3-Methylpiperidine DM49YTN MI TTL2ADK DM49YTN MN Rotamase A (PPIA) DM49YTN MT DTT DM49YTN MA Inhibitor DM49YTN RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DM49YTN RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMEUBGY DI DMEUBGY DMEUBGY DN (3R)-9-amino-3-methyl-1,2,3,4-tetrahydroacridine DMEUBGY MI TT1RS9F DMEUBGY MN Acetylcholinesterase (AChE) DMEUBGY MT DTT DMEUBGY MA Inhibitor DMEUBGY RN Synthesis and AChE inhibitory activity of new chiral tetrahydroacridine analogues from terpenic cyclanones. Eur J Med Chem. 2010 Feb;45(2):526-35. DMEUBGY RU https://pubmed.ncbi.nlm.nih.gov/19954865 DM47BEG DI DM47BEG DM47BEG DN (3R,4S)-293B DM47BEG MI TT846HF DM47BEG MN Voltage-gated potassium channel Kv7.1 (KCNQ1) DM47BEG MT DTT DM47BEG MA Blocker (channel blocker) DM47BEG RN A kinetic study on the stereospecific inhibition of KCNQ1 and I(Ks) by the chromanol 293B. Br J Pharmacol. 2001 Dec;134(8):1647-54. DM47BEG RU https://pubmed.ncbi.nlm.nih.gov/11739240 DMET6IS DI DMET6IS DMET6IS DN (3S,4R)-3-Benzyl-7-isopropyl-chroman-4-ol DMET6IS MI TTN53ZF DMET6IS MN Leukotriene B4 receptor 1 (LTB4R) DMET6IS MT DTT DMET6IS MA Inhibitor DMET6IS RN 3-Substituted-4-hydroxy-7-chromanylacetic acid derivatives as antagonists of the leukotriene B4 (LTB4) receptor, Bioorg. Med. Chem. Lett. 7(17):2307-2312 (1997). DMET6IS RU http://www.sciencedirect.com/science/article/pii/S0960894X97004149 DMET6IS DI DMET6IS DMET6IS DN (3S,4R)-3-Benzyl-7-isopropyl-chroman-4-ol DMET6IS MI TTVJX54 DMET6IS MN Leukotriene B4 receptor 2 (LTB4R2) DMET6IS MT DTT DMET6IS MA Inhibitor DMET6IS RN 3-Substituted-4-hydroxy-7-chromanylacetic acid derivatives as antagonists of the leukotriene B4 (LTB4) receptor, Bioorg. Med. Chem. Lett. 7(17):2307-2312 (1997). DMET6IS RU http://www.sciencedirect.com/science/article/pii/S0960894X97004149 DMAEXO3 DI DMAEXO3 DMAEXO3 DN (3S,4R)-3-butyl-1-phenylpiperidin-4-amine DMAEXO3 MI TTDIGC1 DMAEXO3 MN Dipeptidyl peptidase 4 (DPP-4) DMAEXO3 MT DTT DMAEXO3 MA Inhibitor DMAEXO3 RN 1,3-disubstituted 4-aminopiperidines as useful tools in the optimization of the 2-aminobenzo[a]quinolizine dipeptidyl peptidase IV inhibitors. Bioorg Med Chem Lett. 2007 Jun 1;17(11):2966-70. DMAEXO3 RU https://pubmed.ncbi.nlm.nih.gov/17418568 DM6P35D DI DM6P35D DM6P35D DN (3-Tetradecylamino-cyclohexyl)-phosphonic acid DM6P35D MI TT9JZCK DM6P35D MN Sphingosine-1-phosphate receptor 1 (S1PR1) DM6P35D MT DTT DM6P35D MA Inhibitor DM6P35D RN Design and synthesis of conformationally constrained 3-(N-alkylamino)propylphosphonic acids as potent agonists of sphingosine-1-phosphate (S1P) rec... Bioorg Med Chem Lett. 2004 Oct 4;14(19):4861-6. DM6P35D RU https://pubmed.ncbi.nlm.nih.gov/15341940 DMFMBPT DI DMFMBPT DMFMBPT DN (3-Tetradecylamino-cyclopentyl)-phosphonic acid DMFMBPT MI TT9JZCK DMFMBPT MN Sphingosine-1-phosphate receptor 1 (S1PR1) DMFMBPT MT DTT DMFMBPT MA Inhibitor DMFMBPT RN Design and synthesis of conformationally constrained 3-(N-alkylamino)propylphosphonic acids as potent agonists of sphingosine-1-phosphate (S1P) rec... Bioorg Med Chem Lett. 2004 Oct 4;14(19):4861-6. DMFMBPT RU https://pubmed.ncbi.nlm.nih.gov/15341940 DMI9N8G DI DMI9N8G DMI9N8G DN (3Z)-1H-indole-2,3-dione 3-thiosemicarbazone DMI9N8G MI TTEAID7 DMI9N8G MN Trypanosoma Cruzipain (Trypano CYSP) DMI9N8G MT DTT DMI9N8G MA Inhibitor DMI9N8G RN Synthesis and evaluation of isatins and thiosemicarbazone derivatives against cruzain, falcipain-2 and rhodesain. Bioorg Med Chem Lett. 2003 Oct 20;13(20):3527-30. DMI9N8G RU https://pubmed.ncbi.nlm.nih.gov/14505663 DMWS35F DI DMWS35F DMWS35F DN (4-((1H-imidazol-1-yl)methyl)phenyl)methanol DMWS35F MI TTIQUX7 DMWS35F MN Steroid 11-beta-hydroxylase (CYP11B1) DMWS35F MT DTT DMWS35F MA Inhibitor DMWS35F RN Synthesis, biological evaluation, and molecular modeling of 1-benzyl-1H-imidazoles as selective inhibitors of aldosterone synthase (CYP11B2). J Med Chem. 2010 Feb 25;53(4):1712-25. DMWS35F RU https://pubmed.ncbi.nlm.nih.gov/20121113 DMUOFW8 DI DMUOFW8 DMUOFW8 DN (4-(6-morpholino-9H-purin-2-yl)phenyl)methanol DMUOFW8 MI TTCJG29 DMUOFW8 MN Serine/threonine-protein kinase mTOR (mTOR) DMUOFW8 MT DTT DMUOFW8 MA Inhibitor DMUOFW8 RN Novel purine and pyrazolo[3,4-d]pyrimidine inhibitors of PI3 kinase-alpha: Hit to lead studies. Bioorg Med Chem Lett. 2010 Jan 15;20(2):636-9. DMUOFW8 RU https://pubmed.ncbi.nlm.nih.gov/19969455 DMV2CKN DI DMV2CKN DMV2CKN DN (4-(thiophen-2-yl)phenyl)methanamine DMV2CKN MI TTXZEAJ DMV2CKN MN Leukotriene A-4 hydrolase (LTA4H) DMV2CKN MT DTT DMV2CKN MA Inhibitor DMV2CKN RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DMV2CKN RU https://pubmed.ncbi.nlm.nih.gov/10592235 DM1XY7C DI DM1XY7C DM1XY7C DN (4-benzhydrylpiperazin-1-yl)(cyclohexyl)methanone DM1XY7C MI TT6OEDT DM1XY7C MN Cannabinoid receptor 1 (CB1) DM1XY7C MT DTT DM1XY7C MA Inhibitor DM1XY7C RN Discovery of benzhydrylpiperazine derivatives as CB1 receptor inverse agonists via privileged structure-based approach. Eur J Med Chem. 2010 Mar;45(3):1133-9. DM1XY7C RU https://pubmed.ncbi.nlm.nih.gov/20047779 DM1XY7C DI DM1XY7C DM1XY7C DN (4-benzhydrylpiperazin-1-yl)(cyclohexyl)methanone DM1XY7C MI TTMSFAW DM1XY7C MN Cannabinoid receptor 2 (CB2) DM1XY7C MT DTT DM1XY7C MA Inhibitor DM1XY7C RN Discovery of benzhydrylpiperazine derivatives as CB1 receptor inverse agonists via privileged structure-based approach. Eur J Med Chem. 2010 Mar;45(3):1133-9. DM1XY7C RU https://pubmed.ncbi.nlm.nih.gov/20047779 DMGVDEL DI DMGVDEL DMGVDEL DN (4-benzylpiperidin-1-yl)(2-fluorophenyl)methanone DMGVDEL MI TTVTX4N DMGVDEL MN Bacterial Fatty acid synthetase I (Bact inhA) DMGVDEL MT DTT DMGVDEL MA Inhibitor DMGVDEL RN Inhibition of the Mycobacterium tuberculosis enoyl acyl carrier protein reductase InhA by arylamides. Bioorg Med Chem. 2007 Nov 1;15(21):6649-58. DMGVDEL RU https://pubmed.ncbi.nlm.nih.gov/17723305 DMEQZ5M DI DMEQZ5M DMEQZ5M DN (4-benzylpiperidin-1-yl)(3-chlorophenyl)methanone DMEQZ5M MI TTVTX4N DMEQZ5M MN Bacterial Fatty acid synthetase I (Bact inhA) DMEQZ5M MT DTT DMEQZ5M MA Inhibitor DMEQZ5M RN Inhibition of the Mycobacterium tuberculosis enoyl acyl carrier protein reductase InhA by arylamides. Bioorg Med Chem. 2007 Nov 1;15(21):6649-58. DMEQZ5M RU https://pubmed.ncbi.nlm.nih.gov/17723305 DMS16CO DI DMS16CO DMS16CO DN (4-benzylpiperidin-1-yl)(m-tolyl)methanone DMS16CO MI TTVTX4N DMS16CO MN Bacterial Fatty acid synthetase I (Bact inhA) DMS16CO MT DTT DMS16CO MA Inhibitor DMS16CO RN Inhibition of the Mycobacterium tuberculosis enoyl acyl carrier protein reductase InhA by arylamides. Bioorg Med Chem. 2007 Nov 1;15(21):6649-58. DMS16CO RU https://pubmed.ncbi.nlm.nih.gov/17723305 DMJ81M3 DI DMJ81M3 DMJ81M3 DN (4-benzylpiperidin-1-yl)(p-tolyl)methanone DMJ81M3 MI TTVTX4N DMJ81M3 MN Bacterial Fatty acid synthetase I (Bact inhA) DMJ81M3 MT DTT DMJ81M3 MA Inhibitor DMJ81M3 RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DMJ81M3 RU https://pubmed.ncbi.nlm.nih.gov/10592235 DMS9125 DI DMS9125 DMS9125 DN (4-bromo-1H-pyrazol-1-yl)(m-tolyl)methanone DMS9125 MI TTPLTSQ DMS9125 MN Neutrophil elastase (NE) DMS9125 MT DTT DMS9125 MA Inhibitor DMS9125 RN N-benzoylpyrazoles are novel small-molecule inhibitors of human neutrophil elastase. J Med Chem. 2007 Oct 4;50(20):4928-38. DMS9125 RU https://pubmed.ncbi.nlm.nih.gov/17850059 DM5QDK9 DI DM5QDK9 DM5QDK9 DN (4-bromo-1H-pyrazol-1-yl)(o-tolyl)methanone DM5QDK9 MI TTPLTSQ DM5QDK9 MN Neutrophil elastase (NE) DM5QDK9 MT DTT DM5QDK9 MA Inhibitor DM5QDK9 RN N-benzoylpyrazoles are novel small-molecule inhibitors of human neutrophil elastase. J Med Chem. 2007 Oct 4;50(20):4928-38. DM5QDK9 RU https://pubmed.ncbi.nlm.nih.gov/17850059 DM31OSD DI DM31OSD DM31OSD DN (4-bromo-1H-pyrazol-1-yl)(p-tolyl)methanone DM31OSD MI TT6L509 DM31OSD MN Coagulation factor IIa (F2) DM31OSD MT DTT DM31OSD MA Inhibitor DM31OSD RN N-benzoylpyrazoles are novel small-molecule inhibitors of human neutrophil elastase. J Med Chem. 2007 Oct 4;50(20):4928-38. DM31OSD RU https://pubmed.ncbi.nlm.nih.gov/17850059 DM31OSD DI DM31OSD DM31OSD DN (4-bromo-1H-pyrazol-1-yl)(p-tolyl)methanone DM31OSD MI TTPLTSQ DM31OSD MN Neutrophil elastase (NE) DM31OSD MT DTT DM31OSD MA Inhibitor DM31OSD RN N-benzoylpyrazoles are novel small-molecule inhibitors of human neutrophil elastase. J Med Chem. 2007 Oct 4;50(20):4928-38. DM31OSD RU https://pubmed.ncbi.nlm.nih.gov/17850059 DM31OSD DI DM31OSD DM31OSD DN (4-bromo-1H-pyrazol-1-yl)(p-tolyl)methanone DM31OSD MI TTMF8H9 DM31OSD MN Plasma kallikrein (KLKB1) DM31OSD MT DTT DM31OSD MA Inhibitor DM31OSD RN N-benzoylpyrazoles are novel small-molecule inhibitors of human neutrophil elastase. J Med Chem. 2007 Oct 4;50(20):4928-38. DM31OSD RU https://pubmed.ncbi.nlm.nih.gov/17850059 DM31OSD DI DM31OSD DM31OSD DN (4-bromo-1H-pyrazol-1-yl)(p-tolyl)methanone DM31OSD MI TTGY7WI DM31OSD MN Urokinase-type plasminogen activator (PLAU) DM31OSD MT DTT DM31OSD MA Inhibitor DM31OSD RN N-benzoylpyrazoles are novel small-molecule inhibitors of human neutrophil elastase. J Med Chem. 2007 Oct 4;50(20):4928-38. DM31OSD RU https://pubmed.ncbi.nlm.nih.gov/17850059 DMU1HFM DI DMU1HFM DMU1HFM DN (4-Bromo-butyl)-trimethyl-ammonium DMU1HFM MI TT1RS9F DMU1HFM MN Acetylcholinesterase (AChE) DMU1HFM MT DTT DMU1HFM MA Inhibitor DMU1HFM RN Structure-based alignment and comparative molecular field analysis of acetylcholinesterase inhibitors. J Med Chem. 1996 Dec 20;39(26):5064-71. DMU1HFM RU https://pubmed.ncbi.nlm.nih.gov/8978837 DMLAEPF DI DMLAEPF DMLAEPF DN (4-bromophenyl)(10H-phenothiazin-10-yl)methanone DMLAEPF MI TTEB0GD DMLAEPF MN Cholinesterase (BCHE) DMLAEPF MT DTT DMLAEPF MA Inhibitor DMLAEPF RN Selective reversible inhibition of human butyrylcholinesterase by aryl amide derivatives of phenothiazine. Bioorg Med Chem. 2007 Oct 1;15(19):6367-78. DMLAEPF RU https://pubmed.ncbi.nlm.nih.gov/17681768 DMOCYZJ DI DMOCYZJ DMOCYZJ DN (4-bromophenyl)difluoromethanesulfonamide DMOCYZJ MI TTUNARX DMOCYZJ MN Carbonic anhydrase (CA) DMOCYZJ MT DTT DMOCYZJ MA Inhibitor DMOCYZJ RN Carbonic anhydrase inhibitors: inhibition of the human isozymes I, II, VA, and IX with a library of substituted difluoromethanesulfonamides. Bioorg Med Chem Lett. 2005 Dec 1;15(23):5192-6. DMOCYZJ RU https://pubmed.ncbi.nlm.nih.gov/16203142 DMOCYZJ DI DMOCYZJ DMOCYZJ DN (4-bromophenyl)difluoromethanesulfonamide DMOCYZJ MI TTHQPL7 DMOCYZJ MN Carbonic anhydrase I (CA-I) DMOCYZJ MT DTT DMOCYZJ MA Inhibitor DMOCYZJ RN Carbonic anhydrase inhibitors: inhibition of the human isozymes I, II, VA, and IX with a library of substituted difluoromethanesulfonamides. Bioorg Med Chem Lett. 2005 Dec 1;15(23):5192-6. DMOCYZJ RU https://pubmed.ncbi.nlm.nih.gov/16203142 DMOCYZJ DI DMOCYZJ DMOCYZJ DN (4-bromophenyl)difluoromethanesulfonamide DMOCYZJ MI TTANPDJ DMOCYZJ MN Carbonic anhydrase II (CA-II) DMOCYZJ MT DTT DMOCYZJ MA Inhibitor DMOCYZJ RN Carbonic anhydrase inhibitors: inhibition of the human isozymes I, II, VA, and IX with a library of substituted difluoromethanesulfonamides. Bioorg Med Chem Lett. 2005 Dec 1;15(23):5192-6. DMOCYZJ RU https://pubmed.ncbi.nlm.nih.gov/16203142 DMOCYZJ DI DMOCYZJ DMOCYZJ DN (4-bromophenyl)difluoromethanesulfonamide DMOCYZJ MI TT2LVK8 DMOCYZJ MN Carbonic anhydrase IX (CA-IX) DMOCYZJ MT DTT DMOCYZJ MA Inhibitor DMOCYZJ RN Carbonic anhydrase inhibitors: inhibition of the human isozymes I, II, VA, and IX with a library of substituted difluoromethanesulfonamides. Bioorg Med Chem Lett. 2005 Dec 1;15(23):5192-6. DMOCYZJ RU https://pubmed.ncbi.nlm.nih.gov/16203142 DM4MAZ1 DI DM4MAZ1 DM4MAZ1 DN (4-chloro-1H-pyrazol-1-yl)(o-tolyl)methanone DM4MAZ1 MI TTPLTSQ DM4MAZ1 MN Neutrophil elastase (NE) DM4MAZ1 MT DTT DM4MAZ1 MA Inhibitor DM4MAZ1 RN N-benzoylpyrazoles are novel small-molecule inhibitors of human neutrophil elastase. J Med Chem. 2007 Oct 4;50(20):4928-38. DM4MAZ1 RU https://pubmed.ncbi.nlm.nih.gov/17850059 DMRIWH2 DI DMRIWH2 DMRIWH2 DN (4-Dipropylamino-cyclohexylidene)-acetonitrile DMRIWH2 MI TT4C8EA DMRIWH2 MN Dopamine D3 receptor (D3R) DMRIWH2 MT DTT DMRIWH2 MA Inhibitor DMRIWH2 RN Conjugated enynes as nonaromatic catechol bioisosteres: synthesis, binding experiments, and computational studies of novel dopamine receptor agonis... J Med Chem. 2000 Feb 24;43(4):756-62. DMRIWH2 RU https://pubmed.ncbi.nlm.nih.gov/10691700 DMG27K1 DI DMG27K1 DMG27K1 DN (4e)-4-Aminohex-4-Enoic Acid DMG27K1 MI TTT2LD9 DMG27K1 MN GABA transaminase (ABAT) DMG27K1 MT DTT DMG27K1 MA Inhibitor DMG27K1 RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMG27K1 RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMHQCRU DI DMHQCRU DMHQCRU DN (4-Ethynyl-cyclohex-3-enyl)-dipropyl-amine DMHQCRU MI TTEX248 DMHQCRU MN Dopamine D2 receptor (D2R) DMHQCRU MT DTT DMHQCRU MA Inhibitor DMHQCRU RN Conjugated enynes as nonaromatic catechol bioisosteres: synthesis, binding experiments, and computational studies of novel dopamine receptor agonis... J Med Chem. 2000 Feb 24;43(4):756-62. DMHQCRU RU https://pubmed.ncbi.nlm.nih.gov/10691700 DMHQCRU DI DMHQCRU DMHQCRU DN (4-Ethynyl-cyclohex-3-enyl)-dipropyl-amine DMHQCRU MI TT4C8EA DMHQCRU MN Dopamine D3 receptor (D3R) DMHQCRU MT DTT DMHQCRU MA Inhibitor DMHQCRU RN Novel D3 selective dopaminergics incorporating enyne units as nonaromatic catechol bioisosteres: synthesis, bioactivity, and mutagenesis studies. J Med Chem. 2008 Nov 13;51(21):6829-38. DMHQCRU RU https://pubmed.ncbi.nlm.nih.gov/18834111 DMHQCRU DI DMHQCRU DMHQCRU DN (4-Ethynyl-cyclohex-3-enyl)-dipropyl-amine DMHQCRU MI TTE0A2F DMHQCRU MN Dopamine D4 receptor (D4R) DMHQCRU MT DTT DMHQCRU MA Inhibitor DMHQCRU RN Conjugated enynes as nonaromatic catechol bioisosteres: synthesis, binding experiments, and computational studies of novel dopamine receptor agonis... J Med Chem. 2000 Feb 24;43(4):756-62. DMHQCRU RU https://pubmed.ncbi.nlm.nih.gov/10691700 DM75EAT DI DM75EAT DM75EAT DN (4-Fluoro-phenyl)-(9H-purin-6-yl)-amine DM75EAT MI TTZN7RP DM75EAT MN Rho-associated protein kinase 1 (ROCK1) DM75EAT MT DTT DM75EAT MA Inhibitor DM75EAT RN Synthesis and biological testing of purine derivatives as potential ATP-competitive kinase inhibitors. J Med Chem. 2005 Feb 10;48(3):710-22. DM75EAT RU https://pubmed.ncbi.nlm.nih.gov/15689155 DMYAJQU DI DMYAJQU DMYAJQU DN (4-Fluoro-phenyl)-(9-methyl-9H-purin-6-yl)-amine DMYAJQU MI TT4TQBX DMYAJQU MN Extracellular signal-regulated kinase 2 (ERK2) DMYAJQU MT DTT DMYAJQU MA Inhibitor DMYAJQU RN Synthesis and biological testing of purine derivatives as potential ATP-competitive kinase inhibitors. J Med Chem. 2005 Feb 10;48(3):710-22. DMYAJQU RU https://pubmed.ncbi.nlm.nih.gov/15689155 DMOS68D DI DMOS68D DMOS68D DN (4-fluorophenyl)(pyridin-4-yl)methanone DMOS68D MI TTXZEAJ DMOS68D MN Leukotriene A-4 hydrolase (LTA4H) DMOS68D MT DTT DMOS68D MA Inhibitor DMOS68D RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DMOS68D RU https://pubmed.ncbi.nlm.nih.gov/10592235 DM0KXP1 DI DM0KXP1 DM0KXP1 DN (4-guanidino-benzyl)-carbamic acid benzyl ester DM0KXP1 MI TTGY7WI DM0KXP1 MN Urokinase-type plasminogen activator (PLAU) DM0KXP1 MT DTT DM0KXP1 MA Inhibitor DM0KXP1 RN Small, potent, and selective diaryl phosphonate inhibitors for urokinase-type plasminogen activator with in vivo antimetastatic properties. J Med Chem. 2007 Dec 27;50(26):6638-46. DM0KXP1 RU https://pubmed.ncbi.nlm.nih.gov/18052026 DM1WZXL DI DM1WZXL DM1WZXL DN (4-hexylphenyl)(oxiran-2-yl)methanone DM1WZXL MI TTGER3L DM1WZXL MN Thyroid hormone receptor beta (THRB) DM1WZXL MT DTT DM1WZXL MA Inhibitor DM1WZXL RN Inhibitors of the interaction of a thyroid hormone receptor and coactivators: preliminary structure-activity relationships. J Med Chem. 2007 Nov 1;50(22):5269-80. DM1WZXL RU https://pubmed.ncbi.nlm.nih.gov/17918822 DMRCM5O DI DMRCM5O DMRCM5O DN (4-Hydroxy-phenoxy)-acetic acid DMRCM5O MI TT8DSFC DMRCM5O MN Hydroxyphenylpyruvate dioxygenase (HPD) DMRCM5O MT DTT DMRCM5O MA Inhibitor DMRCM5O RN Design, synthesis, and evaluation of postulated transient intermediate and substrate analogues as inhibitors of 4-hydroxyphenylpyruvate dioxygenase. Bioorg Med Chem Lett. 2002 Jul 8;12(13):1709-13. DMRCM5O RU https://pubmed.ncbi.nlm.nih.gov/12067543 DMOWFE5 DI DMOWFE5 DMOWFE5 DN (4-Iodo-butyl)-trimethyl-ammonium iodide DMOWFE5 MI TT1RS9F DMOWFE5 MN Acetylcholinesterase (AChE) DMOWFE5 MT DTT DMOWFE5 MA Inhibitor DMOWFE5 RN Structure-based alignment and comparative molecular field analysis of acetylcholinesterase inhibitors. J Med Chem. 1996 Dec 20;39(26):5064-71. DMOWFE5 RU https://pubmed.ncbi.nlm.nih.gov/8978837 DMZD0KG DI DMZD0KG DMZD0KG DN (4-methoxyphenyl)(4-phenylazepan-1-yl)methanone DMZD0KG MI TTN7BL9 DMZD0KG MN Corticosteroid 11-beta-dehydrogenase 1 (HSD11B1) DMZD0KG MT DTT DMZD0KG MA Inhibitor DMZD0KG RN The discovery of azepane sulfonamides as potent 11beta-HSD1 inhibitors. Bioorg Med Chem Lett. 2009 Aug 15;19(16):4563-5. DMZD0KG RU https://pubmed.ncbi.nlm.nih.gov/19625185 DMPU7KE DI DMPU7KE DMPU7KE DN (4-Methyl-2-oxo-2H-quinolin-1-yl)-acetic acid DMPU7KE MI TTFBNVI DMPU7KE MN Aldose reductase (AKR1B1) DMPU7KE MT DTT DMPU7KE MA Inhibitor DMPU7KE RN Synthesis and aldose reductase inhibitory activity of substituted 2-oxoquinoline-1-acetic acid derivatives. J Med Chem. 1986 Oct;29(10):2024-8. DMPU7KE RU https://pubmed.ncbi.nlm.nih.gov/3093680 DMBPL3J DI DMBPL3J DMBPL3J DN (4-nitro-1H-pyrazol-1-yl)(o-tolyl)methanone DMBPL3J MI TT6L509 DMBPL3J MN Coagulation factor IIa (F2) DMBPL3J MT DTT DMBPL3J MA Inhibitor DMBPL3J RN N-benzoylpyrazoles are novel small-molecule inhibitors of human neutrophil elastase. J Med Chem. 2007 Oct 4;50(20):4928-38. DMBPL3J RU https://pubmed.ncbi.nlm.nih.gov/17850059 DMBPL3J DI DMBPL3J DMBPL3J DN (4-nitro-1H-pyrazol-1-yl)(o-tolyl)methanone DMBPL3J MI TTPLTSQ DMBPL3J MN Neutrophil elastase (NE) DMBPL3J MT DTT DMBPL3J MA Inhibitor DMBPL3J RN N-benzoylpyrazoles are novel small-molecule inhibitors of human neutrophil elastase. J Med Chem. 2007 Oct 4;50(20):4928-38. DMBPL3J RU https://pubmed.ncbi.nlm.nih.gov/17850059 DMBPL3J DI DMBPL3J DMBPL3J DN (4-nitro-1H-pyrazol-1-yl)(o-tolyl)methanone DMBPL3J MI TTGY7WI DMBPL3J MN Urokinase-type plasminogen activator (PLAU) DMBPL3J MT DTT DMBPL3J MA Inhibitor DMBPL3J RN N-benzoylpyrazoles are novel small-molecule inhibitors of human neutrophil elastase. J Med Chem. 2007 Oct 4;50(20):4928-38. DMBPL3J RU https://pubmed.ncbi.nlm.nih.gov/17850059 DMIDUO9 DI DMIDUO9 DMIDUO9 DN (4-nitro-1H-pyrazol-1-yl)(phenyl)methanone DMIDUO9 MI TT6L509 DMIDUO9 MN Coagulation factor IIa (F2) DMIDUO9 MT DTT DMIDUO9 MA Inhibitor DMIDUO9 RN N-benzoylpyrazoles are novel small-molecule inhibitors of human neutrophil elastase. J Med Chem. 2007 Oct 4;50(20):4928-38. DMIDUO9 RU https://pubmed.ncbi.nlm.nih.gov/17850059 DMIDUO9 DI DMIDUO9 DMIDUO9 DN (4-nitro-1H-pyrazol-1-yl)(phenyl)methanone DMIDUO9 MI TTPLTSQ DMIDUO9 MN Neutrophil elastase (NE) DMIDUO9 MT DTT DMIDUO9 MA Inhibitor DMIDUO9 RN N-benzoylpyrazoles are novel small-molecule inhibitors of human neutrophil elastase. J Med Chem. 2007 Oct 4;50(20):4928-38. DMIDUO9 RU https://pubmed.ncbi.nlm.nih.gov/17850059 DMIDUO9 DI DMIDUO9 DMIDUO9 DN (4-nitro-1H-pyrazol-1-yl)(phenyl)methanone DMIDUO9 MI TTGY7WI DMIDUO9 MN Urokinase-type plasminogen activator (PLAU) DMIDUO9 MT DTT DMIDUO9 MA Inhibitor DMIDUO9 RN N-benzoylpyrazoles are novel small-molecule inhibitors of human neutrophil elastase. J Med Chem. 2007 Oct 4;50(20):4928-38. DMIDUO9 RU https://pubmed.ncbi.nlm.nih.gov/17850059 DM1YC0B DI DM1YC0B DM1YC0B DN (4-nitrophenyl)(10H-phenothiazin-10-yl)methanone DM1YC0B MI TTEB0GD DM1YC0B MN Cholinesterase (BCHE) DM1YC0B MT DTT DM1YC0B MA Inhibitor DM1YC0B RN Selective reversible inhibition of human butyrylcholinesterase by aryl amide derivatives of phenothiazine. Bioorg Med Chem. 2007 Oct 1;15(19):6367-78. DM1YC0B RU https://pubmed.ncbi.nlm.nih.gov/17681768 DMFO8DR DI DMFO8DR DMFO8DR DN (4-Phenoxy-phenyl)-quinazolin-4-yl-amine DMFO8DR MI TT9VGXW DMFO8DR MN Angiopoietin 1 receptor (TEK) DMFO8DR MT DTT DMFO8DR MA Inhibitor DMFO8DR RN Pyrrolo[2,3-d]pyrimidines containing an extended 5-substituent as potent and selective inhibitors of lck I. Bioorg Med Chem Lett. 2000 Oct 2;10(19):2167-70. DMFO8DR RU https://pubmed.ncbi.nlm.nih.gov/11012021 DMFO8DR DI DMFO8DR DMFO8DR DN (4-Phenoxy-phenyl)-quinazolin-4-yl-amine DMFO8DR MI TT860QF DMFO8DR MN LCK tyrosine protein kinase (LCK) DMFO8DR MT DTT DMFO8DR MA Inhibitor DMFO8DR RN Pyrrolo[2,3-d]pyrimidines containing an extended 5-substituent as potent and selective inhibitors of lck I. Bioorg Med Chem Lett. 2000 Oct 2;10(19):2167-70. DMFO8DR RU https://pubmed.ncbi.nlm.nih.gov/11012021 DMFO8DR DI DMFO8DR DMFO8DR DN (4-Phenoxy-phenyl)-quinazolin-4-yl-amine DMFO8DR MI TTUTJGQ DMFO8DR MN Vascular endothelial growth factor receptor 2 (KDR) DMFO8DR MT DTT DMFO8DR MA Inhibitor DMFO8DR RN Pyrrolo[2,3-d]pyrimidines containing an extended 5-substituent as potent and selective inhibitors of lck I. Bioorg Med Chem Lett. 2000 Oct 2;10(19):2167-70. DMFO8DR RU https://pubmed.ncbi.nlm.nih.gov/11012021 DMQM8O5 DI DMQM8O5 DMQM8O5 DN (4-Phenylethynyl-cyclohex-3-enyl)-dipropyl-amine DMQM8O5 MI TT4C8EA DMQM8O5 MN Dopamine D3 receptor (D3R) DMQM8O5 MT DTT DMQM8O5 MA Inhibitor DMQM8O5 RN Conjugated enynes as nonaromatic catechol bioisosteres: synthesis, binding experiments, and computational studies of novel dopamine receptor agonis... J Med Chem. 2000 Feb 24;43(4):756-62. DMQM8O5 RU https://pubmed.ncbi.nlm.nih.gov/10691700 DMQM8O5 DI DMQM8O5 DMQM8O5 DN (4-Phenylethynyl-cyclohex-3-enyl)-dipropyl-amine DMQM8O5 MI TTE0A2F DMQM8O5 MN Dopamine D4 receptor (D4R) DMQM8O5 MT DTT DMQM8O5 MA Inhibitor DMQM8O5 RN Conjugated enynes as nonaromatic catechol bioisosteres: synthesis, binding experiments, and computational studies of novel dopamine receptor agonis... J Med Chem. 2000 Feb 24;43(4):756-62. DMQM8O5 RU https://pubmed.ncbi.nlm.nih.gov/10691700 DM0NTA3 DI DM0NTA3 DM0NTA3 DN (4-phenylpiperazin-1-yl)(p-tolyl)methanone DM0NTA3 MI TTVTX4N DM0NTA3 MN Bacterial Fatty acid synthetase I (Bact inhA) DM0NTA3 MT DTT DM0NTA3 MA Inhibitor DM0NTA3 RN Inhibition of the Mycobacterium tuberculosis enoyl acyl carrier protein reductase InhA by arylamides. Bioorg Med Chem. 2007 Nov 1;15(21):6649-58. DM0NTA3 RU https://pubmed.ncbi.nlm.nih.gov/17723305 DMKF3U6 DI DMKF3U6 DMKF3U6 DN (4-Quinolin-2-ylpiperazin-1-yl)acetic Acid DMKF3U6 MI TTPC4TU DMKF3U6 MN 5-HT 3A receptor (HTR3A) DMKF3U6 MT DTT DMKF3U6 MA Inhibitor DMKF3U6 RN Specific targeting of peripheral serotonin 5-HT(3) receptors. Synthesis, biological investigation, and structure-activity relationships. J Med Chem. 2009 Jun 11;52(11):3548-62. DMKF3U6 RU https://pubmed.ncbi.nlm.nih.gov/19425598 DMKF3U6 DI DMKF3U6 DMKF3U6 DN (4-Quinolin-2-ylpiperazin-1-yl)acetic Acid DMKF3U6 MI TTEX248 DMKF3U6 MN Dopamine D2 receptor (D2R) DMKF3U6 MT DTT DMKF3U6 MA Inhibitor DMKF3U6 RN Specific targeting of peripheral serotonin 5-HT(3) receptors. Synthesis, biological investigation, and structure-activity relationships. J Med Chem. 2009 Jun 11;52(11):3548-62. DMKF3U6 RU https://pubmed.ncbi.nlm.nih.gov/19425598 DMZFTI4 DI DMZFTI4 DMZFTI4 DN (4R)-4-ammoniopentanoate DMZFTI4 MI TT1MPAY DMZFTI4 MN GABA(A) receptor alpha-1 (GABRA1) DMZFTI4 MT DTT DMZFTI4 MA Inhibitor DMZFTI4 RN gamma-Aminobutyric acid agonists, antagonists, and uptake inhibitors. Design and therapeutic aspects. J Med Chem. 1981 Dec;24(12):1377-83. DMZFTI4 RU https://pubmed.ncbi.nlm.nih.gov/6118436 DMZFTI4 DI DMZFTI4 DMZFTI4 DN (4R)-4-ammoniopentanoate DMZFTI4 MI TTBMV1G DMZFTI4 MN GABA(A) receptor alpha-2 (GABRA2) DMZFTI4 MT DTT DMZFTI4 MA Inhibitor DMZFTI4 RN gamma-Aminobutyric acid agonists, antagonists, and uptake inhibitors. Design and therapeutic aspects. J Med Chem. 1981 Dec;24(12):1377-83. DMZFTI4 RU https://pubmed.ncbi.nlm.nih.gov/6118436 DMZFTI4 DI DMZFTI4 DMZFTI4 DN (4R)-4-ammoniopentanoate DMZFTI4 MI TT37EDJ DMZFTI4 MN GABA(A) receptor alpha-3 (GABRA3) DMZFTI4 MT DTT DMZFTI4 MA Inhibitor DMZFTI4 RN gamma-Aminobutyric acid agonists, antagonists, and uptake inhibitors. Design and therapeutic aspects. J Med Chem. 1981 Dec;24(12):1377-83. DMZFTI4 RU https://pubmed.ncbi.nlm.nih.gov/6118436 DMZFTI4 DI DMZFTI4 DMZFTI4 DN (4R)-4-ammoniopentanoate DMZFTI4 MI TTNZPQ1 DMZFTI4 MN GABA(A) receptor alpha-5 (GABRA5) DMZFTI4 MT DTT DMZFTI4 MA Inhibitor DMZFTI4 RN gamma-Aminobutyric acid agonists, antagonists, and uptake inhibitors. Design and therapeutic aspects. J Med Chem. 1981 Dec;24(12):1377-83. DMZFTI4 RU https://pubmed.ncbi.nlm.nih.gov/6118436 DMZFTI4 DI DMZFTI4 DMZFTI4 DN (4R)-4-ammoniopentanoate DMZFTI4 MI TTZA1NY DMZFTI4 MN GABA(A) receptor beta-2 (GABRB2) DMZFTI4 MT DTT DMZFTI4 MA Inhibitor DMZFTI4 RN gamma-Aminobutyric acid agonists, antagonists, and uptake inhibitors. Design and therapeutic aspects. J Med Chem. 1981 Dec;24(12):1377-83. DMZFTI4 RU https://pubmed.ncbi.nlm.nih.gov/6118436 DMZFTI4 DI DMZFTI4 DMZFTI4 DN (4R)-4-ammoniopentanoate DMZFTI4 MI TT06RH5 DMZFTI4 MN GABA(A) receptor gamma-2 (GABRG2) DMZFTI4 MT DTT DMZFTI4 MA Inhibitor DMZFTI4 RN gamma-Aminobutyric acid agonists, antagonists, and uptake inhibitors. Design and therapeutic aspects. J Med Chem. 1981 Dec;24(12):1377-83. DMZFTI4 RU https://pubmed.ncbi.nlm.nih.gov/6118436 DMZFTI4 DI DMZFTI4 DMZFTI4 DN (4R)-4-ammoniopentanoate DMZFTI4 MI TTNJYV2 DMZFTI4 MN Gamma-aminobutyric acid receptor (GAR) DMZFTI4 MT DTT DMZFTI4 MA Inhibitor DMZFTI4 RN gamma-Aminobutyric acid agonists, antagonists, and uptake inhibitors. Design and therapeutic aspects. J Med Chem. 1981 Dec;24(12):1377-83. DMZFTI4 RU https://pubmed.ncbi.nlm.nih.gov/6118436 DMBLAY1 DI DMBLAY1 DMBLAY1 DN (4S)-4-ammoniopentanoate DMBLAY1 MI TT1MPAY DMBLAY1 MN GABA(A) receptor alpha-1 (GABRA1) DMBLAY1 MT DTT DMBLAY1 MA Inhibitor DMBLAY1 RN gamma-Aminobutyric acid agonists, antagonists, and uptake inhibitors. Design and therapeutic aspects. J Med Chem. 1981 Dec;24(12):1377-83. DMBLAY1 RU https://pubmed.ncbi.nlm.nih.gov/6118436 DMBLAY1 DI DMBLAY1 DMBLAY1 DN (4S)-4-ammoniopentanoate DMBLAY1 MI TTBMV1G DMBLAY1 MN GABA(A) receptor alpha-2 (GABRA2) DMBLAY1 MT DTT DMBLAY1 MA Inhibitor DMBLAY1 RN gamma-Aminobutyric acid agonists, antagonists, and uptake inhibitors. Design and therapeutic aspects. J Med Chem. 1981 Dec;24(12):1377-83. DMBLAY1 RU https://pubmed.ncbi.nlm.nih.gov/6118436 DMBLAY1 DI DMBLAY1 DMBLAY1 DN (4S)-4-ammoniopentanoate DMBLAY1 MI TT37EDJ DMBLAY1 MN GABA(A) receptor alpha-3 (GABRA3) DMBLAY1 MT DTT DMBLAY1 MA Inhibitor DMBLAY1 RN gamma-Aminobutyric acid agonists, antagonists, and uptake inhibitors. Design and therapeutic aspects. J Med Chem. 1981 Dec;24(12):1377-83. DMBLAY1 RU https://pubmed.ncbi.nlm.nih.gov/6118436 DMBLAY1 DI DMBLAY1 DMBLAY1 DN (4S)-4-ammoniopentanoate DMBLAY1 MI TTNZPQ1 DMBLAY1 MN GABA(A) receptor alpha-5 (GABRA5) DMBLAY1 MT DTT DMBLAY1 MA Inhibitor DMBLAY1 RN gamma-Aminobutyric acid agonists, antagonists, and uptake inhibitors. Design and therapeutic aspects. J Med Chem. 1981 Dec;24(12):1377-83. DMBLAY1 RU https://pubmed.ncbi.nlm.nih.gov/6118436 DMBLAY1 DI DMBLAY1 DMBLAY1 DN (4S)-4-ammoniopentanoate DMBLAY1 MI TTZA1NY DMBLAY1 MN GABA(A) receptor beta-2 (GABRB2) DMBLAY1 MT DTT DMBLAY1 MA Inhibitor DMBLAY1 RN gamma-Aminobutyric acid agonists, antagonists, and uptake inhibitors. Design and therapeutic aspects. J Med Chem. 1981 Dec;24(12):1377-83. DMBLAY1 RU https://pubmed.ncbi.nlm.nih.gov/6118436 DMBLAY1 DI DMBLAY1 DMBLAY1 DN (4S)-4-ammoniopentanoate DMBLAY1 MI TT06RH5 DMBLAY1 MN GABA(A) receptor gamma-2 (GABRG2) DMBLAY1 MT DTT DMBLAY1 MA Inhibitor DMBLAY1 RN gamma-Aminobutyric acid agonists, antagonists, and uptake inhibitors. Design and therapeutic aspects. J Med Chem. 1981 Dec;24(12):1377-83. DMBLAY1 RU https://pubmed.ncbi.nlm.nih.gov/6118436 DMBLAY1 DI DMBLAY1 DMBLAY1 DN (4S)-4-ammoniopentanoate DMBLAY1 MI TTNJYV2 DMBLAY1 MN Gamma-aminobutyric acid receptor (GAR) DMBLAY1 MT DTT DMBLAY1 MA Inhibitor DMBLAY1 RN gamma-Aminobutyric acid agonists, antagonists, and uptake inhibitors. Design and therapeutic aspects. J Med Chem. 1981 Dec;24(12):1377-83. DMBLAY1 RU https://pubmed.ncbi.nlm.nih.gov/6118436 DMM6QV5 DI DMM6QV5 DMM6QV5 DN (4S,5R)-4,5-Diethyl-oxazolidin-(2Z)-ylideneamine DMM6QV5 MI TTZUFI5 DMM6QV5 MN Nitric-oxide synthase brain (NOS1) DMM6QV5 MT DTT DMM6QV5 MA Inhibitor DMM6QV5 RN 4,5-Disubstituted-1,3-oxazolidin-2-imine derivatives: a new class of orally bioavailable nitric oxide synthase inhibitor. Bioorg Med Chem Lett. 2004 Jan 19;14(2):313-6. DMM6QV5 RU https://pubmed.ncbi.nlm.nih.gov/14698148 DMM6QV5 DI DMM6QV5 DMM6QV5 DN (4S,5R)-4,5-Diethyl-oxazolidin-(2Z)-ylideneamine DMM6QV5 MI TTF10I9 DMM6QV5 MN Nitric-oxide synthase inducible (NOS2) DMM6QV5 MT DTT DMM6QV5 MA Inhibitor DMM6QV5 RN 4,5-Disubstituted-1,3-oxazolidin-2-imine derivatives: a new class of orally bioavailable nitric oxide synthase inhibitor. Bioorg Med Chem Lett. 2004 Jan 19;14(2):313-6. DMM6QV5 RU https://pubmed.ncbi.nlm.nih.gov/14698148 DM0V9HB DI DM0V9HB DM0V9HB DN (4S,5R)-4,5-Dimethyl-oxazolidin-(2Z)-ylideneamine DM0V9HB MI TTZUFI5 DM0V9HB MN Nitric-oxide synthase brain (NOS1) DM0V9HB MT DTT DM0V9HB MA Inhibitor DM0V9HB RN 4,5-Disubstituted-1,3-oxazolidin-2-imine derivatives: a new class of orally bioavailable nitric oxide synthase inhibitor. Bioorg Med Chem Lett. 2004 Jan 19;14(2):313-6. DM0V9HB RU https://pubmed.ncbi.nlm.nih.gov/14698148 DM0V9HB DI DM0V9HB DM0V9HB DN (4S,5R)-4,5-Dimethyl-oxazolidin-(2Z)-ylideneamine DM0V9HB MI TTF10I9 DM0V9HB MN Nitric-oxide synthase inducible (NOS2) DM0V9HB MT DTT DM0V9HB MA Inhibitor DM0V9HB RN 4,5-Disubstituted-1,3-oxazolidin-2-imine derivatives: a new class of orally bioavailable nitric oxide synthase inhibitor. Bioorg Med Chem Lett. 2004 Jan 19;14(2):313-6. DM0V9HB RU https://pubmed.ncbi.nlm.nih.gov/14698148 DMDC84U DI DMDC84U DMDC84U DN (4S,5R)-4,5-Dipropyl-oxazolidin-(2Z)-ylideneamine DMDC84U MI TTF10I9 DMDC84U MN Nitric-oxide synthase inducible (NOS2) DMDC84U MT DTT DMDC84U MA Inhibitor DMDC84U RN 4,5-Disubstituted-1,3-oxazolidin-2-imine derivatives: a new class of orally bioavailable nitric oxide synthase inhibitor. Bioorg Med Chem Lett. 2004 Jan 19;14(2):313-6. DMDC84U RU https://pubmed.ncbi.nlm.nih.gov/14698148 DM1VJUZ DI DM1VJUZ DM1VJUZ DN (4S,5S)-4,5-Diethyl-oxazolidin-(2Z)-ylideneamine DM1VJUZ MI TTZUFI5 DM1VJUZ MN Nitric-oxide synthase brain (NOS1) DM1VJUZ MT DTT DM1VJUZ MA Inhibitor DM1VJUZ RN 4,5-Disubstituted-1,3-oxazolidin-2-imine derivatives: a new class of orally bioavailable nitric oxide synthase inhibitor. Bioorg Med Chem Lett. 2004 Jan 19;14(2):313-6. DM1VJUZ RU https://pubmed.ncbi.nlm.nih.gov/14698148 DM1VJUZ DI DM1VJUZ DM1VJUZ DN (4S,5S)-4,5-Diethyl-oxazolidin-(2Z)-ylideneamine DM1VJUZ MI TTF10I9 DM1VJUZ MN Nitric-oxide synthase inducible (NOS2) DM1VJUZ MT DTT DM1VJUZ MA Inhibitor DM1VJUZ RN 4,5-Disubstituted-1,3-oxazolidin-2-imine derivatives: a new class of orally bioavailable nitric oxide synthase inhibitor. Bioorg Med Chem Lett. 2004 Jan 19;14(2):313-6. DM1VJUZ RU https://pubmed.ncbi.nlm.nih.gov/14698148 DM5EKF4 DI DM5EKF4 DM5EKF4 DN (4S,5S)-4,5-Dipropyl-oxazolidin-(2Z)-ylideneamine DM5EKF4 MI TTF10I9 DM5EKF4 MN Nitric-oxide synthase inducible (NOS2) DM5EKF4 MT DTT DM5EKF4 MA Inhibitor DM5EKF4 RN 4,5-Disubstituted-1,3-oxazolidin-2-imine derivatives: a new class of orally bioavailable nitric oxide synthase inhibitor. Bioorg Med Chem Lett. 2004 Jan 19;14(2):313-6. DM5EKF4 RU https://pubmed.ncbi.nlm.nih.gov/14698148 DMGCZOI DI DMGCZOI DMGCZOI DN (4-sulfamoylphenylethylthioureido)fluorescein DMGCZOI MI TT2LVK8 DMGCZOI MN Carbonic anhydrase IX (CA-IX) DMGCZOI MT DTT DMGCZOI MA Inhibitor DMGCZOI RN Recent developments of carbonic anhydrase inhibitors as potential anticancer drugs. J Med Chem. 2008 Jun 12;51(11):3051-6. DMGCZOI RU https://pubmed.ncbi.nlm.nih.gov/18348513 DM15P2G DI DM15P2G DM15P2G DN (5-(1-benzyl-1H-indazol-3-yl)furan-2-yl)methanol DM15P2G MI TTSN6QU DM15P2G MN HIF1-alpha messenger RNA (HIF1A mRNA) DM15P2G MT DTT DM15P2G MA Inhibitor DM15P2G RN Synthesis of (aryloxyacetylamino)-isonicotinic/nicotinic acid analogues as potent hypoxia-inducible factor (HIF)-1alpha inhibitors. Bioorg Med Chem Lett. 2007 Nov 15;17(22):6305-10. DM15P2G RU https://pubmed.ncbi.nlm.nih.gov/17884495 DM15P2G DI DM15P2G DM15P2G DN (5-(1-benzyl-1H-indazol-3-yl)furan-2-yl)methanol DM15P2G MI TT23PYC DM15P2G MN Soluble guanylate cyclase (GCS) DM15P2G MT DTT DM15P2G MA Activator DM15P2G RN Activators of soluble guanylate cyclase for the treatment of male erectile dysfunction. Int J Impot Res. 2002 Feb;14(1):8-14. DM15P2G RU https://pubmed.ncbi.nlm.nih.gov/11896472 DMTC5VF DI DMTC5VF DMTC5VF DN (5-(pyridin-3-yl)furan-2-yl)methanamine DMTC5VF MI TTVG215 DMTC5VF MN Debrisoquine 4-hydroxylase (CYP2D6) DMTC5VF MT DTT DMTC5VF MA Inhibitor DMTC5VF RN Synthetic inhibitors of cytochrome P-450 2A6: inhibitory activity, difference spectra, mechanism of inhibition, and protein cocrystallization. J Med Chem. 2006 Nov 30;49(24):6987-7001. DMTC5VF RU https://pubmed.ncbi.nlm.nih.gov/17125252 DMF0YJ3 DI DMF0YJ3 DMF0YJ3 DN (5-amino-1-phenyl-1H-pyrazol-4-yl)phenylmethanone DMF0YJ3 MI TTQBR95 DMF0YJ3 MN Stress-activated protein kinase 2a (p38 alpha) DMF0YJ3 MT DTT DMF0YJ3 MA Inhibitor DMF0YJ3 RN Discovery of S-[5-amino-1-(4-fluorophenyl)-1H-pyrazol-4-yl]-[3-(2,3-dihydroxypropoxy)phenyl]methanone (RO3201195), an orally bioavailable and highl... J Med Chem. 2006 Mar 9;49(5):1562-75. DMF0YJ3 RU https://pubmed.ncbi.nlm.nih.gov/16509574 DMVQ6RN DI DMVQ6RN DMVQ6RN DN (5BETA)-PREGNANE-3,20-DIONE DMVQ6RN MI TTRANFM DMVQ6RN MN Orphan nuclear receptor NR1I3 (NR1I3) DMVQ6RN MT DTT DMVQ6RN MA Inhibitor DMVQ6RN RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DMVQ6RN RU https://pubmed.ncbi.nlm.nih.gov/10592235 DMVQ6RN DI DMVQ6RN DMVQ6RN DN (5BETA)-PREGNANE-3,20-DIONE DMVQ6RN MI TT6PEUO DMVQ6RN MN Retinoic acid receptor RXR-alpha (RXRA) DMVQ6RN MT DTT DMVQ6RN MA Inhibitor DMVQ6RN RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DMVQ6RN RU https://pubmed.ncbi.nlm.nih.gov/10592235 DM4EH2J DI DM4EH2J DM4EH2J DN (5-Bromo-pentyl)-trimethyl-ammonium DM4EH2J MI TT1RS9F DM4EH2J MN Acetylcholinesterase (AChE) DM4EH2J MT DTT DM4EH2J MA Inhibitor DM4EH2J RN Structure-based alignment and comparative molecular field analysis of acetylcholinesterase inhibitors. J Med Chem. 1996 Dec 20;39(26):5064-71. DM4EH2J RU https://pubmed.ncbi.nlm.nih.gov/8978837 DM8JHWS DI DM8JHWS DM8JHWS DN (5E,8E,11E,14E)-Icosa-5,8,11,14-tetraenal DM8JHWS MI TTMI6F5 DM8JHWS MN Transient receptor potential cation channel V1 (TRPV1) DM8JHWS MT DTT DM8JHWS MA Inhibitor DM8JHWS RN The taming of capsaicin. Reversal of the vanilloid activity of N-acylvanillamines by aromatic iodination. J Med Chem. 2005 Jul 14;48(14):4663-9. DM8JHWS RU https://pubmed.ncbi.nlm.nih.gov/16000002 DMIV4BU DI DMIV4BU DMIV4BU DN (5-fluoro-1H-indol-2-yl)-(1H-indol-2-yl)methanone DMIV4BU MI TTGJCWZ DMIV4BU MN Fms-like tyrosine kinase 3 (FLT-3) DMIV4BU MT DTT DMIV4BU MA Inhibitor DMIV4BU RN Novel bis(1H-indol-2-yl)methanones as potent inhibitors of FLT3 and platelet-derived growth factor receptor tyrosine kinase. J Med Chem. 2006 Jun 1;49(11):3101-15. DMIV4BU RU https://pubmed.ncbi.nlm.nih.gov/16722630 DMIV4BU DI DMIV4BU DMIV4BU DN (5-fluoro-1H-indol-2-yl)-(1H-indol-2-yl)methanone DMIV4BU MI TT8FYO9 DMIV4BU MN Platelet-derived growth factor receptor alpha (PDGFRA) DMIV4BU MT DTT DMIV4BU MA Inhibitor DMIV4BU RN Novel bis(1H-indol-2-yl)methanones as potent inhibitors of FLT3 and platelet-derived growth factor receptor tyrosine kinase. J Med Chem. 2006 Jun 1;49(11):3101-15. DMIV4BU RU https://pubmed.ncbi.nlm.nih.gov/16722630 DMIV4BU DI DMIV4BU DMIV4BU DN (5-fluoro-1H-indol-2-yl)-(1H-indol-2-yl)methanone DMIV4BU MI TTI7421 DMIV4BU MN Platelet-derived growth factor receptor beta (PDGFRB) DMIV4BU MT DTT DMIV4BU MA Inhibitor DMIV4BU RN Novel bis(1H-indol-2-yl)methanones as potent inhibitors of FLT3 and platelet-derived growth factor receptor tyrosine kinase. J Med Chem. 2006 Jun 1;49(11):3101-15. DMIV4BU RU https://pubmed.ncbi.nlm.nih.gov/16722630 DMPBNYM DI DMPBNYM DMPBNYM DN (5-hydroxy-1H-indol-2-yl)(1H-indol-2-yl)methanone DMPBNYM MI TTGJCWZ DMPBNYM MN Fms-like tyrosine kinase 3 (FLT-3) DMPBNYM MT DTT DMPBNYM MA Inhibitor DMPBNYM RN Novel bis(1H-indol-2-yl)methanones as potent inhibitors of FLT3 and platelet-derived growth factor receptor tyrosine kinase. J Med Chem. 2006 Jun 1;49(11):3101-15. DMPBNYM RU https://pubmed.ncbi.nlm.nih.gov/16722630 DMPBNYM DI DMPBNYM DMPBNYM DN (5-hydroxy-1H-indol-2-yl)(1H-indol-2-yl)methanone DMPBNYM MI TT8FYO9 DMPBNYM MN Platelet-derived growth factor receptor alpha (PDGFRA) DMPBNYM MT DTT DMPBNYM MA Inhibitor DMPBNYM RN Novel bis(1H-indol-2-yl)methanones as potent inhibitors of FLT3 and platelet-derived growth factor receptor tyrosine kinase. J Med Chem. 2006 Jun 1;49(11):3101-15. DMPBNYM RU https://pubmed.ncbi.nlm.nih.gov/16722630 DMPBNYM DI DMPBNYM DMPBNYM DN (5-hydroxy-1H-indol-2-yl)(1H-indol-2-yl)methanone DMPBNYM MI TTI7421 DMPBNYM MN Platelet-derived growth factor receptor beta (PDGFRB) DMPBNYM MT DTT DMPBNYM MA Inhibitor DMPBNYM RN Novel bis(1H-indol-2-yl)methanones as potent inhibitors of FLT3 and platelet-derived growth factor receptor tyrosine kinase. J Med Chem. 2006 Jun 1;49(11):3101-15. DMPBNYM RU https://pubmed.ncbi.nlm.nih.gov/16722630 DMBKZDJ DI DMBKZDJ DMBKZDJ DN (5-Imino-[1,4]thiazepan-3-yl)-methanol DMBKZDJ MI TTZUFI5 DMBKZDJ MN Nitric-oxide synthase brain (NOS1) DMBKZDJ MT DTT DMBKZDJ MA Inhibitor DMBKZDJ RN Synthesis of analogs of (1,4)-3- and 5-imino oxazepane, thiazepane, and diazepane as inhibitors of nitric oxide synthases. Bioorg Med Chem Lett. 2004 Dec 6;14(23):5907-11. DMBKZDJ RU https://pubmed.ncbi.nlm.nih.gov/15501067 DMBKZDJ DI DMBKZDJ DMBKZDJ DN (5-Imino-[1,4]thiazepan-3-yl)-methanol DMBKZDJ MI TTCM4B3 DMBKZDJ MN Nitric-oxide synthase endothelial (NOS3) DMBKZDJ MT DTT DMBKZDJ MA Inhibitor DMBKZDJ RN Synthesis of analogs of (1,4)-3- and 5-imino oxazepane, thiazepane, and diazepane as inhibitors of nitric oxide synthases. Bioorg Med Chem Lett. 2004 Dec 6;14(23):5907-11. DMBKZDJ RU https://pubmed.ncbi.nlm.nih.gov/15501067 DMBKZDJ DI DMBKZDJ DMBKZDJ DN (5-Imino-[1,4]thiazepan-3-yl)-methanol DMBKZDJ MI TTF10I9 DMBKZDJ MN Nitric-oxide synthase inducible (NOS2) DMBKZDJ MT DTT DMBKZDJ MA Inhibitor DMBKZDJ RN Synthesis of analogs of (1,4)-3- and 5-imino oxazepane, thiazepane, and diazepane as inhibitors of nitric oxide synthases. Bioorg Med Chem Lett. 2004 Dec 6;14(23):5907-11. DMBKZDJ RU https://pubmed.ncbi.nlm.nih.gov/15501067 DMOPMNC DI DMOPMNC DMOPMNC DN (5-methoxy-1H-indol-3-yl)methanamine DMOPMNC MI TT0K1SC DMOPMNC MN 5-HT 2B receptor (HTR2B) DMOPMNC MT DTT DMOPMNC MA Inhibitor DMOPMNC RN Development, validation, and use of quantitative structure-activity relationship models of 5-hydroxytryptamine (2B) receptor ligands to identify no... J Med Chem. 2010 Nov 11;53(21):7573-86. DMOPMNC RU https://pubmed.ncbi.nlm.nih.gov/20958049 DM4FJHO DI DM4FJHO DM4FJHO DN (5-Methoxy-chroman-3-yl)-dipropyl-amine DM4FJHO MI TTEX248 DM4FJHO MN Dopamine D2 receptor (D2R) DM4FJHO MT DTT DM4FJHO MA Inhibitor DM4FJHO RN 3-amino-3,4-dihydro-2H-1-benzopyran derivatives as 5-HT1A receptor ligands and potential anxiolytic agents. 2. Synthesis and quantitative structure... J Med Chem. 1996 Oct 11;39(21):4285-98. DM4FJHO RU https://pubmed.ncbi.nlm.nih.gov/8863806 DM2HCUK DI DM2HCUK DM2HCUK DN (5-phenyl-3H-benzo[d]imidazol-4-yl)methanamine DM2HCUK MI TTDIGC1 DM2HCUK MN Dipeptidyl peptidase 4 (DPP-4) DM2HCUK MT DTT DM2HCUK MA Inhibitor DM2HCUK RN Structure-based design and synthesis of benzimidazole derivatives as dipeptidyl peptidase IV inhibitors. Bioorg Med Chem Lett. 2008 Apr 1;18(7):2362-7. DM2HCUK RU https://pubmed.ncbi.nlm.nih.gov/18346892 DMORD8S DI DMORD8S DMORD8S DN (5-phenylfuran-2-yl)methanamine DMORD8S MI TTVG215 DMORD8S MN Debrisoquine 4-hydroxylase (CYP2D6) DMORD8S MT DTT DMORD8S MA Inhibitor DMORD8S RN Synthetic inhibitors of cytochrome P-450 2A6: inhibitory activity, difference spectra, mechanism of inhibition, and protein cocrystallization. J Med Chem. 2006 Nov 30;49(24):6987-7001. DMORD8S RU https://pubmed.ncbi.nlm.nih.gov/17125252 DM1R5SF DI DM1R5SF DM1R5SF DN (5-Phenyl-oxazol-2-yl)-m-tolyl-amine DM1R5SF MI TTUTJGQ DM1R5SF MN Vascular endothelial growth factor receptor 2 (KDR) DM1R5SF MT DTT DM1R5SF MA Inhibitor DM1R5SF RN Discovery and evaluation of 2-anilino-5-aryloxazoles as a novel class of VEGFR2 kinase inhibitors. J Med Chem. 2005 Mar 10;48(5):1610-9. DM1R5SF RU https://pubmed.ncbi.nlm.nih.gov/15743202 DM1R5SF DI DM1R5SF DM1R5SF DN (5-Phenyl-oxazol-2-yl)-m-tolyl-amine DM1R5SF MI TTDCBX5 DM1R5SF MN Vascular endothelial growth factor receptor 3 (FLT-4) DM1R5SF MT DTT DM1R5SF MA Inhibitor DM1R5SF RN Discovery and evaluation of 2-anilino-5-aryloxazoles as a novel class of VEGFR2 kinase inhibitors. J Med Chem. 2005 Mar 10;48(5):1610-9. DM1R5SF RU https://pubmed.ncbi.nlm.nih.gov/15743202 DM1R5SF DI DM1R5SF DM1R5SF DN (5-Phenyl-oxazol-2-yl)-m-tolyl-amine DM1R5SF MI TT1VAUK DM1R5SF MN VEGFR1 messenger RNA (VEGFR1 mRNA) DM1R5SF MT DTT DM1R5SF MA Inhibitor DM1R5SF RN Discovery and evaluation of 2-anilino-5-aryloxazoles as a novel class of VEGFR2 kinase inhibitors. J Med Chem. 2005 Mar 10;48(5):1610-9. DM1R5SF RU https://pubmed.ncbi.nlm.nih.gov/15743202 DMKC2BE DI DMKC2BE DMKC2BE DN (5-pyridin-3-yl-furan-2-yl)methanethiol DMKC2BE MI TTXV4FI DMKC2BE MN Albendazole monooxygenase (CYP3A4) DMKC2BE MT DTT DMKC2BE MA Inhibitor DMKC2BE RN Synthetic inhibitors of cytochrome P-450 2A6: inhibitory activity, difference spectra, mechanism of inhibition, and protein cocrystallization. J Med Chem. 2006 Nov 30;49(24):6987-7001. DMKC2BE RU https://pubmed.ncbi.nlm.nih.gov/17125252 DMKC2BE DI DMKC2BE DMKC2BE DN (5-pyridin-3-yl-furan-2-yl)methanethiol DMKC2BE MI TTVG215 DMKC2BE MN Debrisoquine 4-hydroxylase (CYP2D6) DMKC2BE MT DTT DMKC2BE MA Inhibitor DMKC2BE RN Synthetic inhibitors of cytochrome P-450 2A6: inhibitory activity, difference spectra, mechanism of inhibition, and protein cocrystallization. J Med Chem. 2006 Nov 30;49(24):6987-7001. DMKC2BE RU https://pubmed.ncbi.nlm.nih.gov/17125252 DMREVX9 DI DMREVX9 DMREVX9 DN (5R,6S)-5,6-bis(benzyloxy)cyclohex-2-enone DMREVX9 MI TT9W8GU DMREVX9 MN Gamma-secretase (GS) DMREVX9 MT DTT DMREVX9 MA Inhibitor DMREVX9 RN Novel gamma-secretase inhibitors discovered by library screening of in-house synthetic natural product intermediates. Bioorg Med Chem Lett. 2006 Jul 15;16(14):3813-6. DMREVX9 RU https://pubmed.ncbi.nlm.nih.gov/16682195 DMREVX9 DI DMREVX9 DMREVX9 DN (5R,6S)-5,6-bis(benzyloxy)cyclohex-2-enone DMREVX9 MI TTZ3S8C DMREVX9 MN Presenilin 1 (PSEN1) DMREVX9 MT DTT DMREVX9 MA Inhibitor DMREVX9 RN Novel gamma-secretase inhibitors discovered by library screening of in-house synthetic natural product intermediates. Bioorg Med Chem Lett. 2006 Jul 15;16(14):3813-6. DMREVX9 RU https://pubmed.ncbi.nlm.nih.gov/16682195 DMREVX9 DI DMREVX9 DMREVX9 DN (5R,6S)-5,6-bis(benzyloxy)cyclohex-2-enone DMREVX9 MI TTWN3F4 DMREVX9 MN Presenilin 2 (PSEN2) DMREVX9 MT DTT DMREVX9 MA Inhibitor DMREVX9 RN Novel gamma-secretase inhibitors discovered by library screening of in-house synthetic natural product intermediates. Bioorg Med Chem Lett. 2006 Jul 15;16(14):3813-6. DMREVX9 RU https://pubmed.ncbi.nlm.nih.gov/16682195 DMHG7MU DI DMHG7MU DMHG7MU DN (5R,6S)-6-(benzyloxy)-5-methoxycyclohex-2-enone DMHG7MU MI TT9W8GU DMHG7MU MN Gamma-secretase (GS) DMHG7MU MT DTT DMHG7MU MA Inhibitor DMHG7MU RN Novel gamma-secretase inhibitors discovered by library screening of in-house synthetic natural product intermediates. Bioorg Med Chem Lett. 2006 Jul 15;16(14):3813-6. DMHG7MU RU https://pubmed.ncbi.nlm.nih.gov/16682195 DMHG7MU DI DMHG7MU DMHG7MU DN (5R,6S)-6-(benzyloxy)-5-methoxycyclohex-2-enone DMHG7MU MI TTZ3S8C DMHG7MU MN Presenilin 1 (PSEN1) DMHG7MU MT DTT DMHG7MU MA Inhibitor DMHG7MU RN Novel gamma-secretase inhibitors discovered by library screening of in-house synthetic natural product intermediates. Bioorg Med Chem Lett. 2006 Jul 15;16(14):3813-6. DMHG7MU RU https://pubmed.ncbi.nlm.nih.gov/16682195 DMHG7MU DI DMHG7MU DMHG7MU DN (5R,6S)-6-(benzyloxy)-5-methoxycyclohex-2-enone DMHG7MU MI TTWN3F4 DMHG7MU MN Presenilin 2 (PSEN2) DMHG7MU MT DTT DMHG7MU MA Inhibitor DMHG7MU RN Novel gamma-secretase inhibitors discovered by library screening of in-house synthetic natural product intermediates. Bioorg Med Chem Lett. 2006 Jul 15;16(14):3813-6. DMHG7MU RU https://pubmed.ncbi.nlm.nih.gov/16682195 DMA5DO2 DI DMA5DO2 DMA5DO2 DN (5s)-5-Iododihydro-2,4(1h,3h)-Pyrimidinedione DMA5DO2 MI TTZPS91 DMA5DO2 MN Dihydrothymine dehydrogenase (DPYD) DMA5DO2 MT DTT DMA5DO2 MA Inhibitor DMA5DO2 RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMA5DO2 RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMT9CXD DI DMT9CXD DMT9CXD DN (5S,6R)-[Octahydro-quinolin-(2E)-ylidene]amine DMT9CXD MI TTZUFI5 DMT9CXD MN Nitric-oxide synthase brain (NOS1) DMT9CXD MT DTT DMT9CXD MA Inhibitor DMT9CXD RN Bicyclic amidine inhibitors of nitric oxide synthase: discovery of perhydro-iminopyrindine and perhydro-iminoquinoline as potent, orally active inh... Bioorg Med Chem Lett. 2005 Apr 15;15(8):1997-2001. DMT9CXD RU https://pubmed.ncbi.nlm.nih.gov/15808455 DMT9CXD DI DMT9CXD DMT9CXD DN (5S,6R)-[Octahydro-quinolin-(2E)-ylidene]amine DMT9CXD MI TTCM4B3 DMT9CXD MN Nitric-oxide synthase endothelial (NOS3) DMT9CXD MT DTT DMT9CXD MA Inhibitor DMT9CXD RN Bicyclic amidine inhibitors of nitric oxide synthase: discovery of perhydro-iminopyrindine and perhydro-iminoquinoline as potent, orally active inh... Bioorg Med Chem Lett. 2005 Apr 15;15(8):1997-2001. DMT9CXD RU https://pubmed.ncbi.nlm.nih.gov/15808455 DMT9CXD DI DMT9CXD DMT9CXD DN (5S,6R)-[Octahydro-quinolin-(2E)-ylidene]amine DMT9CXD MI TTF10I9 DMT9CXD MN Nitric-oxide synthase inducible (NOS2) DMT9CXD MT DTT DMT9CXD MA Inhibitor DMT9CXD RN Bicyclic amidine inhibitors of nitric oxide synthase: discovery of perhydro-iminopyrindine and perhydro-iminoquinoline as potent, orally active inh... Bioorg Med Chem Lett. 2005 Apr 15;15(8):1997-2001. DMT9CXD RU https://pubmed.ncbi.nlm.nih.gov/15808455 DMP4UC1 DI DMP4UC1 DMP4UC1 DN (5S,6S)-[Octahydro-quinolin-(2E)-ylidene]amine DMP4UC1 MI TTZUFI5 DMP4UC1 MN Nitric-oxide synthase brain (NOS1) DMP4UC1 MT DTT DMP4UC1 MA Inhibitor DMP4UC1 RN Bicyclic amidine inhibitors of nitric oxide synthase: discovery of perhydro-iminopyrindine and perhydro-iminoquinoline as potent, orally active inh... Bioorg Med Chem Lett. 2005 Apr 15;15(8):1997-2001. DMP4UC1 RU https://pubmed.ncbi.nlm.nih.gov/15808455 DMP4UC1 DI DMP4UC1 DMP4UC1 DN (5S,6S)-[Octahydro-quinolin-(2E)-ylidene]amine DMP4UC1 MI TTCM4B3 DMP4UC1 MN Nitric-oxide synthase endothelial (NOS3) DMP4UC1 MT DTT DMP4UC1 MA Inhibitor DMP4UC1 RN Bicyclic amidine inhibitors of nitric oxide synthase: discovery of perhydro-iminopyrindine and perhydro-iminoquinoline as potent, orally active inh... Bioorg Med Chem Lett. 2005 Apr 15;15(8):1997-2001. DMP4UC1 RU https://pubmed.ncbi.nlm.nih.gov/15808455 DMP4UC1 DI DMP4UC1 DMP4UC1 DN (5S,6S)-[Octahydro-quinolin-(2E)-ylidene]amine DMP4UC1 MI TTF10I9 DMP4UC1 MN Nitric-oxide synthase inducible (NOS2) DMP4UC1 MT DTT DMP4UC1 MA Inhibitor DMP4UC1 RN Bicyclic amidine inhibitors of nitric oxide synthase: discovery of perhydro-iminopyrindine and perhydro-iminoquinoline as potent, orally active inh... Bioorg Med Chem Lett. 2005 Apr 15;15(8):1997-2001. DMP4UC1 RU https://pubmed.ncbi.nlm.nih.gov/15808455 DMA97CS DI DMA97CS DMA97CS DN (5Z,9Z)-5,9-heptacosadienoic acid DMA97CS MI TTGTQHC DMA97CS MN DNA topoisomerase I (TOP1) DMA97CS MT DTT DMA97CS MA Inhibitor DMA97CS RN Total synthesis and biological evaluation of (5Z,9Z)-5,9-hexadecadienoic acid, an inhibitor of human topoisomerase I. J Nat Prod. 2002 Nov;65(11):1715-8. DMA97CS RU https://pubmed.ncbi.nlm.nih.gov/12444712 DMAXS9H DI DMAXS9H DMAXS9H DN (6-Benzylamino-9H-beta-carbolin-3-yl)-methanol DMAXS9H MI TT1MPAY DMAXS9H MN GABA(A) receptor alpha-1 (GABRA1) DMAXS9H MT DTT DMAXS9H MA Inhibitor DMAXS9H RN Synthesis of 6-substituted beta-carbolines that behave as benzodiazepine receptor antagonists or inverse agonists. J Med Chem. 1987 Apr;30(4):750-3. DMAXS9H RU https://pubmed.ncbi.nlm.nih.gov/3031296 DMAXS9H DI DMAXS9H DMAXS9H DN (6-Benzylamino-9H-beta-carbolin-3-yl)-methanol DMAXS9H MI TTNJYV2 DMAXS9H MN Gamma-aminobutyric acid receptor (GAR) DMAXS9H MT DTT DMAXS9H MA Inhibitor DMAXS9H RN Synthesis of 6-substituted beta-carbolines that behave as benzodiazepine receptor antagonists or inverse agonists. J Med Chem. 1987 Apr;30(4):750-3. DMAXS9H RU https://pubmed.ncbi.nlm.nih.gov/3031296 DMF7LST DI DMF7LST DMF7LST DN (6-Benzyloxy-2-naphthyl)-2-aminopropane DMF7LST MI TT3WG5C DMF7LST MN Monoamine oxidase type A (MAO-A) DMF7LST MT DTT DMF7LST MA Inhibitor DMF7LST RN Naphthylisopropylamine and N-benzylamphetamine derivatives as monoamine oxidase inhibitors. Bioorg Med Chem. 2009 Mar 15;17(6):2452-60. DMF7LST RU https://pubmed.ncbi.nlm.nih.gov/19243954 DMF7LST DI DMF7LST DMF7LST DN (6-Benzyloxy-2-naphthyl)-2-aminopropane DMF7LST MI TTGP7BY DMF7LST MN Monoamine oxidase type B (MAO-B) DMF7LST MT DTT DMF7LST MA Inhibitor DMF7LST RN Naphthylisopropylamine and N-benzylamphetamine derivatives as monoamine oxidase inhibitors. Bioorg Med Chem. 2009 Mar 15;17(6):2452-60. DMF7LST RU https://pubmed.ncbi.nlm.nih.gov/19243954 DM7BK9A DI DM7BK9A DM7BK9A DN (6-Butoxy-2-naphthyl)-2-aminopropane DM7BK9A MI TT3WG5C DM7BK9A MN Monoamine oxidase type A (MAO-A) DM7BK9A MT DTT DM7BK9A MA Inhibitor DM7BK9A RN Naphthylisopropylamine and N-benzylamphetamine derivatives as monoamine oxidase inhibitors. Bioorg Med Chem. 2009 Mar 15;17(6):2452-60. DM7BK9A RU https://pubmed.ncbi.nlm.nih.gov/19243954 DMM2EX6 DI DMM2EX6 DMM2EX6 DN (6-Ethoxy-2-naphthyl)-2-aminopropane DMM2EX6 MI TT3WG5C DMM2EX6 MN Monoamine oxidase type A (MAO-A) DMM2EX6 MT DTT DMM2EX6 MA Inhibitor DMM2EX6 RN Naphthylisopropylamine and N-benzylamphetamine derivatives as monoamine oxidase inhibitors. Bioorg Med Chem. 2009 Mar 15;17(6):2452-60. DMM2EX6 RU https://pubmed.ncbi.nlm.nih.gov/19243954 DMM2EX6 DI DMM2EX6 DMM2EX6 DN (6-Ethoxy-2-naphthyl)-2-aminopropane DMM2EX6 MI TTGP7BY DMM2EX6 MN Monoamine oxidase type B (MAO-B) DMM2EX6 MT DTT DMM2EX6 MA Inhibitor DMM2EX6 RN Naphthylisopropylamine and N-benzylamphetamine derivatives as monoamine oxidase inhibitors. Bioorg Med Chem. 2009 Mar 15;17(6):2452-60. DMM2EX6 RU https://pubmed.ncbi.nlm.nih.gov/19243954 DMQJ5RU DI DMQJ5RU DMQJ5RU DN (6-Hydroxy-2-oxo-2H-quinolin-1-yl)-acetic acid DMQJ5RU MI TTFBNVI DMQJ5RU MN Aldose reductase (AKR1B1) DMQJ5RU MT DTT DMQJ5RU MA Inhibitor DMQJ5RU RN Synthesis and aldose reductase inhibitory activity of substituted 2-oxoquinoline-1-acetic acid derivatives. J Med Chem. 1986 Oct;29(10):2024-8. DMQJ5RU RU https://pubmed.ncbi.nlm.nih.gov/3093680 DM6YGQ3 DI DM6YGQ3 DM6YGQ3 DN (6-Methoxy-2-naphthyl)-2-aminopropane DM6YGQ3 MI TT3WG5C DM6YGQ3 MN Monoamine oxidase type A (MAO-A) DM6YGQ3 MT DTT DM6YGQ3 MA Inhibitor DM6YGQ3 RN Naphthylisopropylamine and N-benzylamphetamine derivatives as monoamine oxidase inhibitors. Bioorg Med Chem. 2009 Mar 15;17(6):2452-60. DM6YGQ3 RU https://pubmed.ncbi.nlm.nih.gov/19243954 DM6YGQ3 DI DM6YGQ3 DM6YGQ3 DN (6-Methoxy-2-naphthyl)-2-aminopropane DM6YGQ3 MI TTGP7BY DM6YGQ3 MN Monoamine oxidase type B (MAO-B) DM6YGQ3 MT DTT DM6YGQ3 MA Inhibitor DM6YGQ3 RN Naphthylisopropylamine and N-benzylamphetamine derivatives as monoamine oxidase inhibitors. Bioorg Med Chem. 2009 Mar 15;17(6):2452-60. DM6YGQ3 RU https://pubmed.ncbi.nlm.nih.gov/19243954 DMTYXFU DI DMTYXFU DMTYXFU DN (6-Methoxy-2-oxo-2H-quinolin-1-yl)-acetic acid DMTYXFU MI TTFBNVI DMTYXFU MN Aldose reductase (AKR1B1) DMTYXFU MT DTT DMTYXFU MA Inhibitor DMTYXFU RN Synthesis and aldose reductase inhibitory activity of substituted 2-oxoquinoline-1-acetic acid derivatives. J Med Chem. 1986 Oct;29(10):2024-8. DMTYXFU RU https://pubmed.ncbi.nlm.nih.gov/3093680 DM39W5K DI DM39W5K DM39W5K DN (6-methylthio-2-naphthyl)isopropylamine DM39W5K MI TT3WG5C DM39W5K MN Monoamine oxidase type A (MAO-A) DM39W5K MT DTT DM39W5K MA Inhibitor DM39W5K RN Naphthylisopropylamine and N-benzylamphetamine derivatives as monoamine oxidase inhibitors. Bioorg Med Chem. 2009 Mar 15;17(6):2452-60. DM39W5K RU https://pubmed.ncbi.nlm.nih.gov/19243954 DMIFL3V DI DMIFL3V DMIFL3V DN (6-Propoxy-2-naphthyl)-2-aminopropane DMIFL3V MI TT3WG5C DMIFL3V MN Monoamine oxidase type A (MAO-A) DMIFL3V MT DTT DMIFL3V MA Inhibitor DMIFL3V RN Naphthylisopropylamine and N-benzylamphetamine derivatives as monoamine oxidase inhibitors. Bioorg Med Chem. 2009 Mar 15;17(6):2452-60. DMIFL3V RU https://pubmed.ncbi.nlm.nih.gov/19243954 DMIFL3V DI DMIFL3V DMIFL3V DN (6-Propoxy-2-naphthyl)-2-aminopropane DMIFL3V MI TTGP7BY DMIFL3V MN Monoamine oxidase type B (MAO-B) DMIFL3V MT DTT DMIFL3V MA Inhibitor DMIFL3V RN Naphthylisopropylamine and N-benzylamphetamine derivatives as monoamine oxidase inhibitors. Bioorg Med Chem. 2009 Mar 15;17(6):2452-60. DMIFL3V RU https://pubmed.ncbi.nlm.nih.gov/19243954 DMOD9R7 DI DMOD9R7 DMOD9R7 DN (6r,1'r,2's)-5,6,7,8 Tetrahydrobiopterin DMOD9R7 MI TTZUFI5 DMOD9R7 MN Nitric-oxide synthase brain (NOS1) DMOD9R7 MT DTT DMOD9R7 MA Inhibitor DMOD9R7 RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMOD9R7 RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMOD9R7 DI DMOD9R7 DMOD9R7 DN (6r,1'r,2's)-5,6,7,8 Tetrahydrobiopterin DMOD9R7 MI TTCM4B3 DMOD9R7 MN Nitric-oxide synthase endothelial (NOS3) DMOD9R7 MT DTT DMOD9R7 MA Inhibitor DMOD9R7 RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMOD9R7 RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMOD9R7 DI DMOD9R7 DMOD9R7 DN (6r,1'r,2's)-5,6,7,8 Tetrahydrobiopterin DMOD9R7 MI TTF10I9 DMOD9R7 MN Nitric-oxide synthase inducible (NOS2) DMOD9R7 MT DTT DMOD9R7 MA Inhibitor DMOD9R7 RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMOD9R7 RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMRAC6T DI DMRAC6T DMRAC6T DN (6s)-5,6,7,8-Tetrahydrofolate DMRAC6T MI TTU6BFZ DMRAC6T MN Candida Thymidylate synthase (Candi TMP1) DMRAC6T MT DTT DMRAC6T MA Inhibitor DMRAC6T RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMRAC6T RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMB9YAO DI DMB9YAO DMB9YAO DN (7-Benzyloxy-2-oxo-2H-chromen-4-yl)acetonitrile DMB9YAO MI TT3WG5C DMB9YAO MN Monoamine oxidase type A (MAO-A) DMB9YAO MT DTT DMB9YAO MA Inhibitor DMB9YAO RN Discovery of a novel class of potent coumarin monoamine oxidase B inhibitors: development and biopharmacological profiling of 7-[(3-chlorobenzyl)ox... J Med Chem. 2009 Nov 12;52(21):6685-706. DMB9YAO RU https://pubmed.ncbi.nlm.nih.gov/19810674 DMB9YAO DI DMB9YAO DMB9YAO DN (7-Benzyloxy-2-oxo-2H-chromen-4-yl)acetonitrile DMB9YAO MI TTGP7BY DMB9YAO MN Monoamine oxidase type B (MAO-B) DMB9YAO MT DTT DMB9YAO MA Inhibitor DMB9YAO RN Discovery of a novel class of potent coumarin monoamine oxidase B inhibitors: development and biopharmacological profiling of 7-[(3-chlorobenzyl)ox... J Med Chem. 2009 Nov 12;52(21):6685-706. DMB9YAO RU https://pubmed.ncbi.nlm.nih.gov/19810674 DMRU0IB DI DMRU0IB DMRU0IB DN (8-Hydroxy-2-oxo-2H-quinolin-1-yl)-acetic acid DMRU0IB MI TTFBNVI DMRU0IB MN Aldose reductase (AKR1B1) DMRU0IB MT DTT DMRU0IB MA Inhibitor DMRU0IB RN Synthesis and aldose reductase inhibitory activity of substituted 2-oxoquinoline-1-acetic acid derivatives. J Med Chem. 1986 Oct;29(10):2024-8. DMRU0IB RU https://pubmed.ncbi.nlm.nih.gov/3093680 DM1UGQN DI DM1UGQN DM1UGQN DN (8R,8'R)-4-hydroxycubebinone DM1UGQN MI TTXV4FI DM1UGQN MN Albendazole monooxygenase (CYP3A4) DM1UGQN MT DTT DM1UGQN MA Inhibitor DM1UGQN RN Potent CYP3A4 inhibitory constituents of Piper cubeba. J Nat Prod. 2005 Jan;68(1):64-8. DM1UGQN RU https://pubmed.ncbi.nlm.nih.gov/15679319 DMVIHTF DI DMVIHTF DMVIHTF DN (8R,8'R,9'S)-5-methoxyclusin DMVIHTF MI TTXV4FI DMVIHTF MN Albendazole monooxygenase (CYP3A4) DMVIHTF MT DTT DMVIHTF MA Inhibitor DMVIHTF RN Potent CYP3A4 inhibitory constituents of Piper cubeba. J Nat Prod. 2005 Jan;68(1):64-8. DMVIHTF RU https://pubmed.ncbi.nlm.nih.gov/15679319 DMHJG5N DI DMHJG5N DMHJG5N DN (9-Benzyl-9H-purin-6-yl)-cyclopropyl-amine DMHJG5N MI TT1MPAY DMHJG5N MN GABA(A) receptor alpha-1 (GABRA1) DMHJG5N MT DTT DMHJG5N MA Inhibitor DMHJG5N RN Benzodiazepine receptor binding activity of 6,9-disubstituted purines. J Med Chem. 1989 May;32(5):1020-4. DMHJG5N RU https://pubmed.ncbi.nlm.nih.gov/2540330 DMHJG5N DI DMHJG5N DMHJG5N DN (9-Benzyl-9H-purin-6-yl)-cyclopropyl-amine DMHJG5N MI TTZA1NY DMHJG5N MN GABA(A) receptor beta-2 (GABRB2) DMHJG5N MT DTT DMHJG5N MA Inhibitor DMHJG5N RN Benzodiazepine receptor binding activity of 6,9-disubstituted purines. J Med Chem. 1989 May;32(5):1020-4. DMHJG5N RU https://pubmed.ncbi.nlm.nih.gov/2540330 DMHJG5N DI DMHJG5N DMHJG5N DN (9-Benzyl-9H-purin-6-yl)-cyclopropyl-amine DMHJG5N MI TT06RH5 DMHJG5N MN GABA(A) receptor gamma-2 (GABRG2) DMHJG5N MT DTT DMHJG5N MA Inhibitor DMHJG5N RN Benzodiazepine receptor binding activity of 6,9-disubstituted purines. J Med Chem. 1989 May;32(5):1020-4. DMHJG5N RU https://pubmed.ncbi.nlm.nih.gov/2540330 DMHJG5N DI DMHJG5N DMHJG5N DN (9-Benzyl-9H-purin-6-yl)-cyclopropyl-amine DMHJG5N MI TTNJYV2 DMHJG5N MN Gamma-aminobutyric acid receptor (GAR) DMHJG5N MT DTT DMHJG5N MA Inhibitor DMHJG5N RN Benzodiazepine receptor binding activity of 6,9-disubstituted purines. J Med Chem. 1989 May;32(5):1020-4. DMHJG5N RU https://pubmed.ncbi.nlm.nih.gov/2540330 DMKI2Y9 DI DMKI2Y9 DMKI2Y9 DN (9H-beta-Carbolin-3-yl)-carbamic acid ethyl ester DMKI2Y9 MI TT1MPAY DMKI2Y9 MN GABA(A) receptor alpha-1 (GABRA1) DMKI2Y9 MT DTT DMKI2Y9 MA Inhibitor DMKI2Y9 RN 3-Amino-beta-carboline derivatives and the benzodiazepine receptor. Synthesis of a selective antagonist of the sedative action of diazepam. J Med Chem. 1985 Jun;28(6):824-8. DMKI2Y9 RU https://pubmed.ncbi.nlm.nih.gov/2989520 DMKI2Y9 DI DMKI2Y9 DMKI2Y9 DN (9H-beta-Carbolin-3-yl)-carbamic acid ethyl ester DMKI2Y9 MI TTNJYV2 DMKI2Y9 MN Gamma-aminobutyric acid receptor (GAR) DMKI2Y9 MT DTT DMKI2Y9 MA Inhibitor DMKI2Y9 RN 3-Amino-beta-carboline derivatives and the benzodiazepine receptor. Synthesis of a selective antagonist of the sedative action of diazepam. J Med Chem. 1985 Jun;28(6):824-8. DMKI2Y9 RU https://pubmed.ncbi.nlm.nih.gov/2989520 DMVHMPC DI DMVHMPC DMVHMPC DN (9H-beta-Carbolin-3-yl)-ethyl-amine DMVHMPC MI TT1MPAY DMVHMPC MN GABA(A) receptor alpha-1 (GABRA1) DMVHMPC MT DTT DMVHMPC MA Inhibitor DMVHMPC RN 3-Amino-beta-carboline derivatives and the benzodiazepine receptor. Synthesis of a selective antagonist of the sedative action of diazepam. J Med Chem. 1985 Jun;28(6):824-8. DMVHMPC RU https://pubmed.ncbi.nlm.nih.gov/2989520 DMVHMPC DI DMVHMPC DMVHMPC DN (9H-beta-Carbolin-3-yl)-ethyl-amine DMVHMPC MI TTNJYV2 DMVHMPC MN Gamma-aminobutyric acid receptor (GAR) DMVHMPC MT DTT DMVHMPC MA Inhibitor DMVHMPC RN 3-Amino-beta-carboline derivatives and the benzodiazepine receptor. Synthesis of a selective antagonist of the sedative action of diazepam. J Med Chem. 1985 Jun;28(6):824-8. DMVHMPC RU https://pubmed.ncbi.nlm.nih.gov/2989520 DMUF16A DI DMUF16A DMUF16A DN (9H-beta-Carbolin-3-yl)-methanol DMUF16A MI TT1MPAY DMUF16A MN GABA(A) receptor alpha-1 (GABRA1) DMUF16A MT DTT DMUF16A MA Inhibitor DMUF16A RN Synthesis of 6-substituted beta-carbolines that behave as benzodiazepine receptor antagonists or inverse agonists. J Med Chem. 1987 Apr;30(4):750-3. DMUF16A RU https://pubmed.ncbi.nlm.nih.gov/3031296 DMUF16A DI DMUF16A DMUF16A DN (9H-beta-Carbolin-3-yl)-methanol DMUF16A MI TTNJYV2 DMUF16A MN Gamma-aminobutyric acid receptor (GAR) DMUF16A MT DTT DMUF16A MA Inhibitor DMUF16A RN Synthesis of 6-substituted beta-carbolines that behave as benzodiazepine receptor antagonists or inverse agonists. J Med Chem. 1987 Apr;30(4):750-3. DMUF16A RU https://pubmed.ncbi.nlm.nih.gov/3031296 DMWJNFC DI DMWJNFC DMWJNFC DN (9-Methyl-9H-purin-6-yl)-phenyl-amine DMWJNFC MI TTK25J1 DMWJNFC MN Adenosine A1 receptor (ADORA1) DMWJNFC MT DTT DMWJNFC MA Inhibitor DMWJNFC RN N6,9-disubstituted adenines: potent, selective antagonists at the A1 adenosine receptor. J Med Chem. 1991 Sep;34(9):2877-82. DMWJNFC RU https://pubmed.ncbi.nlm.nih.gov/1895305 DM12GHQ DI DM12GHQ DM12GHQ DN (9Z,11E,13S)-13-hydroxyoctadeca-9,11-dienoic acid DM12GHQ MI TTZMAO3 DM12GHQ MN Peroxisome proliferator-activated receptor gamma (PPAR-gamma) DM12GHQ MT DTT DM12GHQ MA Inhibitor DM12GHQ RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DM12GHQ RU https://pubmed.ncbi.nlm.nih.gov/10592235 DM2REIN DI DM2REIN DM2REIN DN (9Z,12E)-12-nitrooctadeca-9,12-dienoic acid DM2REIN MI TTJ584C DM2REIN MN Peroxisome proliferator-activated receptor alpha (PPARA) DM2REIN MT DTT DM2REIN MA Inhibitor DM2REIN RN Activation of peroxisome proliferator-activated receptor gamma (PPARgamma) by nitroalkene fatty acids: importance of nitration position and degree ... J Med Chem. 2009 Aug 13;52(15):4631-9. DM2REIN RU https://pubmed.ncbi.nlm.nih.gov/19719236 DM2REIN DI DM2REIN DM2REIN DN (9Z,12E)-12-nitrooctadeca-9,12-dienoic acid DM2REIN MI TTT2SVW DM2REIN MN PPAR-gamma messenger RNA (PPARG mRNA) DM2REIN MT DTT DM2REIN MA Inhibitor DM2REIN RN Activation of peroxisome proliferator-activated receptor gamma (PPARgamma) by nitroalkene fatty acids: importance of nitration position and degree ... J Med Chem. 2009 Aug 13;52(15):4631-9. DM2REIN RU https://pubmed.ncbi.nlm.nih.gov/19719236 DMS4ZVK DI DMS4ZVK DMS4ZVK DN (Amino-phenyl-methyl)-phosphinic acid DMS4ZVK MI TTPHMWB DMS4ZVK MN Aminopeptidase N (ANPEP) DMS4ZVK MT DTT DMS4ZVK MA Inhibitor DMS4ZVK RN Design of the first highly potent and selective aminopeptidase N (EC 3.4.11.2) inhibitor. Bioorg Med Chem Lett. 1999 Jun 7;9(11):1511-6. DMS4ZVK RU https://pubmed.ncbi.nlm.nih.gov/10386926 DME80RK DI DME80RK DME80RK DN (benzo[b]furan-2-yl)-(1H-indol-2-yl)methanone DME80RK MI TTGJCWZ DME80RK MN Fms-like tyrosine kinase 3 (FLT-3) DME80RK MT DTT DME80RK MA Inhibitor DME80RK RN Inhibition of FLT3 and PDGFR tyrosine kinase activity by bis(benzo[b]furan-2-yl)methanones. Bioorg Med Chem. 2007 Mar 1;15(5):2187-97. DME80RK RU https://pubmed.ncbi.nlm.nih.gov/17210255 DME80RK DI DME80RK DME80RK DN (benzo[b]furan-2-yl)-(1H-indol-2-yl)methanone DME80RK MI TTI7421 DME80RK MN Platelet-derived growth factor receptor beta (PDGFRB) DME80RK MT DTT DME80RK MA Inhibitor DME80RK RN Inhibition of FLT3 and PDGFR tyrosine kinase activity by bis(benzo[b]furan-2-yl)methanones. Bioorg Med Chem. 2007 Mar 1;15(5):2187-97. DME80RK RU https://pubmed.ncbi.nlm.nih.gov/17210255 DMVWQ26 DI DMVWQ26 DMVWQ26 DN (beta-CCE)9H-beta-Carboline-3-carboxylic acid DMVWQ26 MI TT1MPAY DMVWQ26 MN GABA(A) receptor alpha-1 (GABRA1) DMVWQ26 MT DTT DMVWQ26 MA Inhibitor DMVWQ26 RN Benzodiazepine receptor affinity and interaction of some N-(indol-3-ylglyoxylyl)amine derivatives. J Med Chem. 1992 Jun 12;35(12):2214-20. DMVWQ26 RU https://pubmed.ncbi.nlm.nih.gov/1319492 DMVWQ26 DI DMVWQ26 DMVWQ26 DN (beta-CCE)9H-beta-Carboline-3-carboxylic acid DMVWQ26 MI TT06RH5 DMVWQ26 MN GABA(A) receptor gamma-2 (GABRG2) DMVWQ26 MT DTT DMVWQ26 MA Inhibitor DMVWQ26 RN Benzodiazepine receptor affinity and interaction of some N-(indol-3-ylglyoxylyl)amine derivatives. J Med Chem. 1992 Jun 12;35(12):2214-20. DMVWQ26 RU https://pubmed.ncbi.nlm.nih.gov/1319492 DMVWQ26 DI DMVWQ26 DMVWQ26 DN (beta-CCE)9H-beta-Carboline-3-carboxylic acid DMVWQ26 MI TTNJYV2 DMVWQ26 MN Gamma-aminobutyric acid receptor (GAR) DMVWQ26 MT DTT DMVWQ26 MA Inhibitor DMVWQ26 RN Benzodiazepine receptor affinity and interaction of some N-(indol-3-ylglyoxylyl)amine derivatives. J Med Chem. 1992 Jun 12;35(12):2214-20. DMVWQ26 RU https://pubmed.ncbi.nlm.nih.gov/1319492 DMGB97I DI DMGB97I DMGB97I DN (biphenyl-3-ylamino)methylenediphosphonic acid DMGB97I MI TTIKWV4 DMGB97I MN Geranyltranstransferase (FDPS) DMGB97I MT DTT DMGB97I MA Inhibitor DMGB97I RN Bisphosphonate inhibitors of ATP-mediated HIV-1 reverse transcriptase catalyzed excision of chain-terminating 3'-azido, 3'-deoxythymidine: a QSAR i... Bioorg Med Chem. 2008 Oct 1;16(19):8959-67. DMGB97I RU https://pubmed.ncbi.nlm.nih.gov/18789701 DM5WH6R DI DM5WH6R DM5WH6R DN (C8-R)-Hydantocidin 5'-Phosphate DM5WH6R MI TTYQ4AE DM5WH6R MN Plasmodium Adenylosuccinate synthetase (Malaria Adss) DM5WH6R MT DTT DM5WH6R MA Inhibitor DM5WH6R RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DM5WH6R RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMMH179 DI DMMH179 DMMH179 DN (C8-S)-Hydantocidin 5'-Phosphate DMMH179 MI TTYQ4AE DMMH179 MN Plasmodium Adenylosuccinate synthetase (Malaria Adss) DMMH179 MT DTT DMMH179 MA Inhibitor DMMH179 RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMMH179 RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMZB0C3 DI DMZB0C3 DMZB0C3 DN (Carboxyhydroxyamino)Ethanoic Acid DMZB0C3 MI TTYQ4AE DMZB0C3 MN Plasmodium Adenylosuccinate synthetase (Malaria Adss) DMZB0C3 MT DTT DMZB0C3 MA Inhibitor DMZB0C3 RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMZB0C3 RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMD0P4G DI DMD0P4G DMD0P4G DN (CH3)CCO-His-Trp-Ala-Val-Gly-His-Leu-Met-NH2 DMD0P4G MI TTC1MVT DMD0P4G MN Gastrin-releasing peptide receptor (GRPR) DMD0P4G MT DTT DMD0P4G MA Inhibitor DMD0P4G RN Gastrin releasing peptide antagonists with improved potency and stability. J Med Chem. 1991 Jul;34(7):2102-7. DMD0P4G RU https://pubmed.ncbi.nlm.nih.gov/2066982 DMMC139 DI DMMC139 DMMC139 DN (cis)-1,6-diphenyl-3-aza-bicyclo[3.1.0]hexane DMMC139 MI TTVBI8W DMMC139 MN Dopamine transporter (DAT) DMMC139 MT DTT DMMC139 MA Inhibitor DMMC139 RN Studies on the structure-activity relationship of bicifadine analogs as monoamine transporter inhibitors. Bioorg Med Chem Lett. 2008 Jul 1;18(13):3682-6. DMMC139 RU https://pubmed.ncbi.nlm.nih.gov/18539031 DMMC139 DI DMMC139 DMMC139 DN (cis)-1,6-diphenyl-3-aza-bicyclo[3.1.0]hexane DMMC139 MI TT3ROYC DMMC139 MN Serotonin transporter (SERT) DMMC139 MT DTT DMMC139 MA Inhibitor DMMC139 RN Studies on the structure-activity relationship of bicifadine analogs as monoamine transporter inhibitors. Bioorg Med Chem Lett. 2008 Jul 1;18(13):3682-6. DMMC139 RU https://pubmed.ncbi.nlm.nih.gov/18539031 DMGXTSB DI DMGXTSB DMGXTSB DN (D)-Ala-Pro-Glu DMGXTSB MI TTLD29N DMGXTSB MN Glutamate receptor ionotropic NMDA 1 (NMDAR1) DMGXTSB MT DTT DMGXTSB MA Inhibitor DMGXTSB RN New Gly-Pro-Glu (GPE) analogues: expedite solid-phase synthesis and biological activity. Bioorg Med Chem Lett. 2006 Mar 1;16(5):1392-6. DMGXTSB RU https://pubmed.ncbi.nlm.nih.gov/16321525 DMGXTSB DI DMGXTSB DMGXTSB DN (D)-Ala-Pro-Glu DMGXTSB MI TTKJEMQ DMGXTSB MN Glutamate receptor ionotropic NMDA 2A (NMDAR2A) DMGXTSB MT DTT DMGXTSB MA Inhibitor DMGXTSB RN New Gly-Pro-Glu (GPE) analogues: expedite solid-phase synthesis and biological activity. Bioorg Med Chem Lett. 2006 Mar 1;16(5):1392-6. DMGXTSB RU https://pubmed.ncbi.nlm.nih.gov/16321525 DMGXTSB DI DMGXTSB DMGXTSB DN (D)-Ala-Pro-Glu DMGXTSB MI TTN9D8E DMGXTSB MN Glutamate receptor ionotropic NMDA 2B (NMDAR2B) DMGXTSB MT DTT DMGXTSB MA Inhibitor DMGXTSB RN New Gly-Pro-Glu (GPE) analogues: expedite solid-phase synthesis and biological activity. Bioorg Med Chem Lett. 2006 Mar 1;16(5):1392-6. DMGXTSB RU https://pubmed.ncbi.nlm.nih.gov/16321525 DMWE42T DI DMWE42T DMWE42T DN (D)Arg-Arg-Pro-Hyp-Gly-Phe-Ser-(d)Phe-Phe-Arg DMWE42T MI TTGY8IW DMWE42T MN B2 bradykinin receptor (BDKRB2) DMWE42T MT DTT DMWE42T MA Inhibitor DMWE42T RN Design and conformational analysis of several highly potent bradykinin receptor antagonists. J Med Chem. 1991 Mar;34(3):1230-3. DMWE42T RU https://pubmed.ncbi.nlm.nih.gov/1848297 DMYSE3O DI DMYSE3O DMYSE3O DN (D)Arg-Arg-Pro-Hyp-Gly-Thi-Cys-(D)Phe-Phe-Cys-Arg DMYSE3O MI TTGY8IW DMYSE3O MN B2 bradykinin receptor (BDKRB2) DMYSE3O MT DTT DMYSE3O MA Inhibitor DMYSE3O RN Design and conformational analysis of several highly potent bradykinin receptor antagonists. J Med Chem. 1991 Mar;34(3):1230-3. DMYSE3O RU https://pubmed.ncbi.nlm.nih.gov/1848297 DMLSJKM DI DMLSJKM DMLSJKM DN (D)Arg-Arg-Pro-Hyp-Gly-Thi-Ser-(D)Tic-Aoc-Arg DMLSJKM MI TTGY8IW DMLSJKM MN B2 bradykinin receptor (BDKRB2) DMLSJKM MT DTT DMLSJKM MA Inhibitor DMLSJKM RN Design and conformational analysis of several highly potent bradykinin receptor antagonists. J Med Chem. 1991 Mar;34(3):1230-3. DMLSJKM RU https://pubmed.ncbi.nlm.nih.gov/1848297 DMP0627 DI DMP0627 DMP0627 DN (D)Arg-Arg-Pro-Hyp-Gly-Thi-Ser-(D)Tic-Tic-Arg DMP0627 MI TTGY8IW DMP0627 MN B2 bradykinin receptor (BDKRB2) DMP0627 MT DTT DMP0627 MA Inhibitor DMP0627 RN Design and conformational analysis of several highly potent bradykinin receptor antagonists. J Med Chem. 1991 Mar;34(3):1230-3. DMP0627 RU https://pubmed.ncbi.nlm.nih.gov/1848297 DM5ZIUW DI DM5ZIUW DM5ZIUW DN (D)-Phe-(D)-Phe-NH2 DM5ZIUW MI TTZPO1L DM5ZIUW MN Substance-P receptor (TACR1) DM5ZIUW MT DTT DM5ZIUW MA Inhibitor DM5ZIUW RN Discovery of dipeptides with high affinity to the specific binding site for substance P1-7. J Med Chem. 2010 Mar 25;53(6):2383-9. DM5ZIUW RU https://pubmed.ncbi.nlm.nih.gov/20178322 DMS32YA DI DMS32YA DMS32YA DN (D)-Phe-(L)-Phe-NH2 DMS32YA MI TTZPO1L DMS32YA MN Substance-P receptor (TACR1) DMS32YA MT DTT DMS32YA MA Inhibitor DMS32YA RN Discovery of dipeptides with high affinity to the specific binding site for substance P1-7. J Med Chem. 2010 Mar 25;53(6):2383-9. DMS32YA RU https://pubmed.ncbi.nlm.nih.gov/20178322 DMQN14X DI DMQN14X DMQN14X DN (D)Phe-Gln-Trp-Ala-Val-Gly-His-Leu-Leu-NH2 DMQN14X MI TTC1MVT DMQN14X MN Gastrin-releasing peptide receptor (GRPR) DMQN14X MT DTT DMQN14X MA Inhibitor DMQN14X RN Synthesis and biological evaluation of bombesin constrained analogues. J Med Chem. 2000 Jun 15;43(12):2356-61. DMQN14X RU https://pubmed.ncbi.nlm.nih.gov/10882361 DMI39LV DI DMI39LV DMI39LV DN (D-Arg)(9)-p19(ARF) 26-44 peptide DMI39LV MI TTD3KOX DMI39LV MN Forkhead box protein M1 (FOXM1) DMI39LV MT DTT DMI39LV MA Inhibitor DMI39LV RN Foxm1b transcription factor is essential for development of hepatocellular carcinomas and is negatively regulated by the p19ARF tumor suppressor. Genes Dev. 2004 Apr 1;18(7):830-50. DMI39LV RU https://pubmed.ncbi.nlm.nih.gov/15082532 DMHSJAT DI DMHSJAT DMHSJAT DN (E)-(thiophen-2-ylmethylidene)amino benzoate DMHSJAT MI TTDNFMT DMHSJAT MN Platelet-activating factor acetylhydrolase (PLA2G7) DMHSJAT MT DTT DMHSJAT MA Inhibitor DMHSJAT RN (E)-Phenyl- and -heteroaryl-substituted O-benzoyl-(or acyl)oximes as lipoprotein-associated phospholipase A2 inhibitors. Bioorg Med Chem Lett. 2005 Mar 1;15(5):1525-7. DMHSJAT RU https://pubmed.ncbi.nlm.nih.gov/15713421 DMBXK5L DI DMBXK5L DMBXK5L DN (E)-1-(4-heptylphenyl)but-2-en-1-one DMBXK5L MI TTTSEPU DMBXK5L MN Thyroid hormone receptor alpha (THRA) DMBXK5L MT DTT DMBXK5L MA Inhibitor DMBXK5L RN Inhibitors of the interaction of a thyroid hormone receptor and coactivators: preliminary structure-activity relationships. J Med Chem. 2007 Nov 1;50(22):5269-80. DMBXK5L RU https://pubmed.ncbi.nlm.nih.gov/17918822 DMBXK5L DI DMBXK5L DMBXK5L DN (E)-1-(4-heptylphenyl)but-2-en-1-one DMBXK5L MI TTGER3L DMBXK5L MN Thyroid hormone receptor beta (THRB) DMBXK5L MT DTT DMBXK5L MA Inhibitor DMBXK5L RN Inhibitors of the interaction of a thyroid hormone receptor and coactivators: preliminary structure-activity relationships. J Med Chem. 2007 Nov 1;50(22):5269-80. DMBXK5L RU https://pubmed.ncbi.nlm.nih.gov/17918822 DMEP903 DI DMEP903 DMEP903 DN (E)-1-(4-Nitro-phenyl)-3-pyridin-2-yl-propenone DMEP903 MI TTSFWA7 DMEP903 MN Plasmodium CDK Pfmrk (Malaria Pfmrk) DMEP903 MT DTT DMEP903 MA Inhibitor DMEP903 RN A three-dimensional in silico pharmacophore model for inhibition of Plasmodium falciparum cyclin-dependent kinases and discovery of different class... J Med Chem. 2004 Oct 21;47(22):5418-26. DMEP903 RU https://pubmed.ncbi.nlm.nih.gov/15481979 DMO38CP DI DMO38CP DMO38CP DN (E)-10-Nitrohexadec-9-enoic Acid DMO38CP MI TTT2SVW DMO38CP MN PPAR-gamma messenger RNA (PPARG mRNA) DMO38CP MT DTT DMO38CP MA Inhibitor DMO38CP RN Activation of peroxisome proliferator-activated receptor gamma (PPARgamma) by nitroalkene fatty acids: importance of nitration position and degree ... J Med Chem. 2009 Aug 13;52(15):4631-9. DMO38CP RU https://pubmed.ncbi.nlm.nih.gov/19719236 DMTF7JA DI DMTF7JA DMTF7JA DN (E)-10-nitrooctadec-9-enoic acid DMTF7JA MI TTT2SVW DMTF7JA MN PPAR-gamma messenger RNA (PPARG mRNA) DMTF7JA MT DTT DMTF7JA MA Inhibitor DMTF7JA RN Activation of peroxisome proliferator-activated receptor gamma (PPARgamma) by nitroalkene fatty acids: importance of nitration position and degree ... J Med Chem. 2009 Aug 13;52(15):4631-9. DMTF7JA RU https://pubmed.ncbi.nlm.nih.gov/19719236 DMBQTZL DI DMBQTZL DMBQTZL DN (E)-12-Nitrooctadec-12-enoic Acid DMBQTZL MI TTJ584C DMBQTZL MN Peroxisome proliferator-activated receptor alpha (PPARA) DMBQTZL MT DTT DMBQTZL MA Inhibitor DMBQTZL RN Activation of peroxisome proliferator-activated receptor gamma (PPARgamma) by nitroalkene fatty acids: importance of nitration position and degree ... J Med Chem. 2009 Aug 13;52(15):4631-9. DMBQTZL RU https://pubmed.ncbi.nlm.nih.gov/19719236 DMBQTZL DI DMBQTZL DMBQTZL DN (E)-12-Nitrooctadec-12-enoic Acid DMBQTZL MI TTT2SVW DMBQTZL MN PPAR-gamma messenger RNA (PPARG mRNA) DMBQTZL MT DTT DMBQTZL MA Inhibitor DMBQTZL RN Activation of peroxisome proliferator-activated receptor gamma (PPARgamma) by nitroalkene fatty acids: importance of nitration position and degree ... J Med Chem. 2009 Aug 13;52(15):4631-9. DMBQTZL RU https://pubmed.ncbi.nlm.nih.gov/19719236 DMF74GJ DI DMF74GJ DMF74GJ DN (E)-13-Nitrooctadec-12-enoic Acid DMF74GJ MI TTJ584C DMF74GJ MN Peroxisome proliferator-activated receptor alpha (PPARA) DMF74GJ MT DTT DMF74GJ MA Inhibitor DMF74GJ RN Activation of peroxisome proliferator-activated receptor gamma (PPARgamma) by nitroalkene fatty acids: importance of nitration position and degree ... J Med Chem. 2009 Aug 13;52(15):4631-9. DMF74GJ RU https://pubmed.ncbi.nlm.nih.gov/19719236 DMF74GJ DI DMF74GJ DMF74GJ DN (E)-13-Nitrooctadec-12-enoic Acid DMF74GJ MI TTT2SVW DMF74GJ MN PPAR-gamma messenger RNA (PPARG mRNA) DMF74GJ MT DTT DMF74GJ MA Inhibitor DMF74GJ RN Activation of peroxisome proliferator-activated receptor gamma (PPARgamma) by nitroalkene fatty acids: importance of nitration position and degree ... J Med Chem. 2009 Aug 13;52(15):4631-9. DMF74GJ RU https://pubmed.ncbi.nlm.nih.gov/19719236 DMQ9TWD DI DMQ9TWD DMQ9TWD DN (E)-1-Adamantan-1-yl-3-quinolin-3-yl-propenone DMQ9TWD MI TTVBPDM DMQ9TWD MN Metabotropic glutamate receptor 1 (mGluR1) DMQ9TWD MT DTT DMQ9TWD MA Inhibitor DMQ9TWD RN Synergism of virtual screening and medicinal chemistry: identification and optimization of allosteric antagonists of metabotropic glutamate recepto... Bioorg Med Chem. 2009 Aug 1;17(15):5708-15. DMQ9TWD RU https://pubmed.ncbi.nlm.nih.gov/19574055 DMQ9TWD DI DMQ9TWD DMQ9TWD DN (E)-1-Adamantan-1-yl-3-quinolin-3-yl-propenone DMQ9TWD MI TTHS256 DMQ9TWD MN Metabotropic glutamate receptor 5 (mGluR5) DMQ9TWD MT DTT DMQ9TWD MA Inhibitor DMQ9TWD RN Synergism of virtual screening and medicinal chemistry: identification and optimization of allosteric antagonists of metabotropic glutamate recepto... Bioorg Med Chem. 2009 Aug 1;17(15):5708-15. DMQ9TWD RU https://pubmed.ncbi.nlm.nih.gov/19574055 DMI146O DI DMI146O DMI146O DN (E)-2-(1-decyl-2-oxoindolin-3-ylidene)acetic acid DMI146O MI TTLZS4Q DMI146O MN M-phase inducer phosphatase 1 (MPIP1) DMI146O MT DTT DMI146O MA Inhibitor DMI146O RN Design and synthesis of N-alkyl oxindolylidene acetic acids as a new class of potent Cdc25A inhibitors. Bioorg Med Chem Lett. 2008 Jun 1;18(11):3350-3. DMI146O RU https://pubmed.ncbi.nlm.nih.gov/18442908 DMH2U4Z DI DMH2U4Z DMH2U4Z DN (E)-2-(4-(methylsulfonyl)styryl)furan DMH2U4Z MI TTVKILB DMH2U4Z MN Prostaglandin G/H synthase 2 (COX-2) DMH2U4Z MT DTT DMH2U4Z MA Inhibitor DMH2U4Z RN Sulfonamide derivatives of styrylheterocycles as a potent inhibitor of COX-2-mediated prostaglandin E2 production. Bioorg Med Chem Lett. 2010 Dec 1;20(23):6938-41. DMH2U4Z RU https://pubmed.ncbi.nlm.nih.gov/20970329 DMDFE1R DI DMDFE1R DMDFE1R DN (E)-2-(4-(methylsulfonyl)styryl)thiophene DMDFE1R MI TTVKILB DMDFE1R MN Prostaglandin G/H synthase 2 (COX-2) DMDFE1R MT DTT DMDFE1R MA Inhibitor DMDFE1R RN Sulfonamide derivatives of styrylheterocycles as a potent inhibitor of COX-2-mediated prostaglandin E2 production. Bioorg Med Chem Lett. 2010 Dec 1;20(23):6938-41. DMDFE1R RU https://pubmed.ncbi.nlm.nih.gov/20970329 DMTJI4F DI DMTJI4F DMTJI4F DN (E)-2-(4-fluorostyryl)-5-(phenylsulfinyl)pyridine DMTJI4F MI TTJQOD7 DMTJI4F MN 5-HT 2A receptor (HTR2A) DMTJI4F MT DTT DMTJI4F MA Inhibitor DMTJI4F RN 2,5-Disubstituted pyridines: the discovery of a novel series of 5-HT2A ligands. Bioorg Med Chem Lett. 2007 May 1;17(9):2643-8. DMTJI4F RU https://pubmed.ncbi.nlm.nih.gov/17314044 DMTJI4F DI DMTJI4F DMTJI4F DN (E)-2-(4-fluorostyryl)-5-(phenylsulfinyl)pyridine DMTJI4F MI TTWJBZ5 DMTJI4F MN 5-HT 2C receptor (HTR2C) DMTJI4F MT DTT DMTJI4F MA Inhibitor DMTJI4F RN 2,5-Disubstituted pyridines: the discovery of a novel series of 5-HT2A ligands. Bioorg Med Chem Lett. 2007 May 1;17(9):2643-8. DMTJI4F RU https://pubmed.ncbi.nlm.nih.gov/17314044 DMTJI4F DI DMTJI4F DMTJI4F DN (E)-2-(4-fluorostyryl)-5-(phenylsulfinyl)pyridine DMTJI4F MI TTQ6VDM DMTJI4F MN Voltage-gated potassium channel Kv11.1 (KCNH2) DMTJI4F MT DTT DMTJI4F MA Inhibitor DMTJI4F RN 2,5-Disubstituted pyridines: the discovery of a novel series of 5-HT2A ligands. Bioorg Med Chem Lett. 2007 May 1;17(9):2643-8. DMTJI4F RU https://pubmed.ncbi.nlm.nih.gov/17314044 DM7P5VM DI DM7P5VM DM7P5VM DN (E)-2-(4-fluorostyryl)-5-(phenylsulfonyl)pyridine DM7P5VM MI TTJQOD7 DM7P5VM MN 5-HT 2A receptor (HTR2A) DM7P5VM MT DTT DM7P5VM MA Inhibitor DM7P5VM RN 2,5-Disubstituted pyridines: the discovery of a novel series of 5-HT2A ligands. Bioorg Med Chem Lett. 2007 May 1;17(9):2643-8. DM7P5VM RU https://pubmed.ncbi.nlm.nih.gov/17314044 DM1LG27 DI DM1LG27 DM1LG27 DN (E)-3-(2,3-dichlorophenylimino)indolin-2-one DM1LG27 MI TTOPAY7 DM1LG27 MN Galanin receptor (GAL-R) DM1LG27 MT DTT DM1LG27 MA Inhibitor DM1LG27 RN 3-arylimino-2-indolones are potent and selective galanin GAL3 receptor antagonists. J Med Chem. 2006 Jun 29;49(13):3757-8. DM1LG27 RU https://pubmed.ncbi.nlm.nih.gov/16789730 DMOWGT3 DI DMOWGT3 DMOWGT3 DN (E)-3-(4-(4-phenoxybenzoyl)phenyl)acrylic acid DMOWGT3 MI TTTU72V DMOWGT3 MN Steroid 5-alpha-reductase 1 (SRD5A1) DMOWGT3 MT DTT DMOWGT3 MA Inhibitor DMOWGT3 RN Novel 5alpha-reductase inhibitors: synthesis, structure-activity studies, and pharmacokinetic profile of phenoxybenzoylphenyl acetic acids. J Med Chem. 2006 Jan 26;49(2):748-59. DMOWGT3 RU https://pubmed.ncbi.nlm.nih.gov/16420060 DMOWGT3 DI DMOWGT3 DMOWGT3 DN (E)-3-(4-(4-phenoxybenzoyl)phenyl)acrylic acid DMOWGT3 MI TTT02K8 DMOWGT3 MN Steroid 5-alpha-reductase 2 (SRD5A2) DMOWGT3 MT DTT DMOWGT3 MA Inhibitor DMOWGT3 RN Novel 5alpha-reductase inhibitors: synthesis, structure-activity studies, and pharmacokinetic profile of phenoxybenzoylphenyl acetic acids. J Med Chem. 2006 Jan 26;49(2):748-59. DMOWGT3 RU https://pubmed.ncbi.nlm.nih.gov/16420060 DMUS0D8 DI DMUS0D8 DMUS0D8 DN (E)-3-(4-(methylsulfonyl)styryl)thiophene DMUS0D8 MI TTVKILB DMUS0D8 MN Prostaglandin G/H synthase 2 (COX-2) DMUS0D8 MT DTT DMUS0D8 MA Inhibitor DMUS0D8 RN Sulfonamide derivatives of styrylheterocycles as a potent inhibitor of COX-2-mediated prostaglandin E2 production. Bioorg Med Chem Lett. 2010 Dec 1;20(23):6938-41. DMUS0D8 RU https://pubmed.ncbi.nlm.nih.gov/20970329 DMPOYK2 DI DMPOYK2 DMPOYK2 DN (E)-3-(4-chlorophenylimino)indolin-2-one DMPOYK2 MI TTOPAY7 DMPOYK2 MN Galanin receptor (GAL-R) DMPOYK2 MT DTT DMPOYK2 MA Inhibitor DMPOYK2 RN 3-arylimino-2-indolones are potent and selective galanin GAL3 receptor antagonists. J Med Chem. 2006 Jun 29;49(13):3757-8. DMPOYK2 RU https://pubmed.ncbi.nlm.nih.gov/16789730 DMX4U9L DI DMX4U9L DMX4U9L DN (E)-3-(4-hydroxybenzylidene)indolin-2-one DMX4U9L MI TT4DXQT DMX4U9L MN Proto-oncogene c-Ret (RET) DMX4U9L MT DTT DMX4U9L MA Inhibitor DMX4U9L RN Synthesis, structure-activity relationship and crystallographic studies of 3-substituted indolin-2-one RET inhibitors. Bioorg Med Chem. 2010 Feb 15;18(4):1482-96. DMX4U9L RU https://pubmed.ncbi.nlm.nih.gov/20117004 DMTKCAL DI DMTKCAL DMTKCAL DN (E)-3-(4-tert-Butyl-phenyl)-N-phenyl-acrylamide DMTKCAL MI TTMI6F5 DMTKCAL MN Transient receptor potential cation channel V1 (TRPV1) DMTKCAL MT DTT DMTKCAL MA Inhibitor DMTKCAL RN Discovery of potent, orally available vanilloid receptor-1 antagonists. Structure-activity relationship of N-aryl cinnamides. J Med Chem. 2005 Jan 13;48(1):71-90. DMTKCAL RU https://pubmed.ncbi.nlm.nih.gov/15634002 DMITXKJ DI DMITXKJ DMITXKJ DN (E)-3-[2-(2-methyl-4-thiazolyl)vinyl]pyridine DMITXKJ MI TTHS256 DMITXKJ MN Metabotropic glutamate receptor 5 (mGluR5) DMITXKJ MT DTT DMITXKJ MA Inhibitor DMITXKJ RN Synthesis and structure-activity relationships of 3-[(2-methyl-1,3-thiazol-4-yl)ethynyl]pyridine analogues as potent, noncompetitive metabotropic g... J Med Chem. 2006 Feb 9;49(3):1080-100. DMITXKJ RU https://pubmed.ncbi.nlm.nih.gov/16451073 DMDF7M4 DI DMDF7M4 DMDF7M4 DN (E)-4-(2-(furan-2-yl)vinyl)benzenesulfonamide DMDF7M4 MI TTVKILB DMDF7M4 MN Prostaglandin G/H synthase 2 (COX-2) DMDF7M4 MT DTT DMDF7M4 MA Inhibitor DMDF7M4 RN Sulfonamide derivatives of styrylheterocycles as a potent inhibitor of COX-2-mediated prostaglandin E2 production. Bioorg Med Chem Lett. 2010 Dec 1;20(23):6938-41. DMDF7M4 RU https://pubmed.ncbi.nlm.nih.gov/20970329 DM7204O DI DM7204O DM7204O DN (E)-4-(2-(thiophen-2-yl)vinyl)benzenesulfonamide DM7204O MI TTVKILB DM7204O MN Prostaglandin G/H synthase 2 (COX-2) DM7204O MT DTT DM7204O MA Inhibitor DM7204O RN Sulfonamide derivatives of styrylheterocycles as a potent inhibitor of COX-2-mediated prostaglandin E2 production. Bioorg Med Chem Lett. 2010 Dec 1;20(23):6938-41. DM7204O RU https://pubmed.ncbi.nlm.nih.gov/20970329 DMTAB8W DI DMTAB8W DMTAB8W DN (E)-4-(2-(thiophen-3-yl)vinyl)benzenesulfonamide DMTAB8W MI TTVKILB DMTAB8W MN Prostaglandin G/H synthase 2 (COX-2) DMTAB8W MT DTT DMTAB8W MA Inhibitor DMTAB8W RN Sulfonamide derivatives of styrylheterocycles as a potent inhibitor of COX-2-mediated prostaglandin E2 production. Bioorg Med Chem Lett. 2010 Dec 1;20(23):6938-41. DMTAB8W RU https://pubmed.ncbi.nlm.nih.gov/20970329 DMYXI2V DI DMYXI2V DMYXI2V DN (E)-4-(3,5-dimethoxystyryl)phenol DMYXI2V MI TTS7G69 DMYXI2V MN Fusion protein Bcr-Abl (Bcr-Abl) DMYXI2V MT DTT DMYXI2V MA Inhibitor DMYXI2V RN Identification of a terphenyl derivative that blocks the cell cycle in the G0-G1 phase and induces differentiation in leukemia cells. J Med Chem. 2006 May 18;49(10):3012-8. DMYXI2V RU https://pubmed.ncbi.nlm.nih.gov/16686543 DMYXI2V DI DMYXI2V DMYXI2V DN (E)-4-(3,5-dimethoxystyryl)phenol DMYXI2V MI TTJ584C DMYXI2V MN Peroxisome proliferator-activated receptor alpha (PPARA) DMYXI2V MT DTT DMYXI2V MA Agonist DMYXI2V RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 593). DMYXI2V RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=593 DMJGAFV DI DMJGAFV DMJGAFV DN (E)-4,4-Dimethyl-1-quinolin-3-yl-pent-1-en-3-one DMJGAFV MI TTVBPDM DMJGAFV MN Metabotropic glutamate receptor 1 (mGluR1) DMJGAFV MT DTT DMJGAFV MA Inhibitor DMJGAFV RN Synergism of virtual screening and medicinal chemistry: identification and optimization of allosteric antagonists of metabotropic glutamate recepto... Bioorg Med Chem. 2009 Aug 1;17(15):5708-15. DMJGAFV RU https://pubmed.ncbi.nlm.nih.gov/19574055 DM75OHG DI DM75OHG DM75OHG DN (E)-4-Methyl-6-(prop-1-enyl)pyridin-2-amine DM75OHG MI TTF10I9 DM75OHG MN Nitric-oxide synthase inducible (NOS2) DM75OHG MT DTT DM75OHG MA Inhibitor DM75OHG RN Design and synthesis of 2-amino-4-methylpyridine analogues as inhibitors for inducible nitric oxide synthase and in vivo evaluation of [18F]6-(2-fl... J Med Chem. 2009 Apr 23;52(8):2443-53. DM75OHG RU https://pubmed.ncbi.nlm.nih.gov/19323559 DMLIQUA DI DMLIQUA DMLIQUA DN (E)-5-(3-Chlorostyryl)isatin DMLIQUA MI TT3WG5C DMLIQUA MN Monoamine oxidase type A (MAO-A) DMLIQUA MT DTT DMLIQUA MA Inhibitor DMLIQUA RN Inhibition of monoamine oxidase by (E)-styrylisatin analogues. Bioorg Med Chem Lett. 2009 May 1;19(9):2509-13. DMLIQUA RU https://pubmed.ncbi.nlm.nih.gov/19342233 DMLIQUA DI DMLIQUA DMLIQUA DN (E)-5-(3-Chlorostyryl)isatin DMLIQUA MI TTGP7BY DMLIQUA MN Monoamine oxidase type B (MAO-B) DMLIQUA MT DTT DMLIQUA MA Inhibitor DMLIQUA RN Inhibition of monoamine oxidase by (E)-styrylisatin analogues. Bioorg Med Chem Lett. 2009 May 1;19(9):2509-13. DMLIQUA RU https://pubmed.ncbi.nlm.nih.gov/19342233 DMP4T9Z DI DMP4T9Z DMP4T9Z DN (E)-5-(3-Fluorostyryl)isatin DMP4T9Z MI TT3WG5C DMP4T9Z MN Monoamine oxidase type A (MAO-A) DMP4T9Z MT DTT DMP4T9Z MA Inhibitor DMP4T9Z RN Inhibition of monoamine oxidase by (E)-styrylisatin analogues. Bioorg Med Chem Lett. 2009 May 1;19(9):2509-13. DMP4T9Z RU https://pubmed.ncbi.nlm.nih.gov/19342233 DMP4T9Z DI DMP4T9Z DMP4T9Z DN (E)-5-(3-Fluorostyryl)isatin DMP4T9Z MI TTGP7BY DMP4T9Z MN Monoamine oxidase type B (MAO-B) DMP4T9Z MT DTT DMP4T9Z MA Inhibitor DMP4T9Z RN Inhibition of monoamine oxidase by (E)-styrylisatin analogues. Bioorg Med Chem Lett. 2009 May 1;19(9):2509-13. DMP4T9Z RU https://pubmed.ncbi.nlm.nih.gov/19342233 DM81JRF DI DM81JRF DM81JRF DN (E)-5-(4-Hydroxybenzylidene)-1-phenethylhydantoin DM81JRF MI TTGKNB4 DM81JRF MN Epidermal growth factor receptor (EGFR) DM81JRF MT DTT DM81JRF MA Inhibitor DM81JRF RN 5-Benzylidene-hydantoins: synthesis and antiproliferative activity on A549 lung cancer cell line. Eur J Med Chem. 2009 Sep;44(9):3471-9. DM81JRF RU https://pubmed.ncbi.nlm.nih.gov/19268405 DMJKOFW DI DMJKOFW DMJKOFW DN (E)-5-Nitrooctadec-5-enoic Acid DMJKOFW MI TTT2SVW DMJKOFW MN PPAR-gamma messenger RNA (PPARG mRNA) DMJKOFW MT DTT DMJKOFW MA Inhibitor DMJKOFW RN Activation of peroxisome proliferator-activated receptor gamma (PPARgamma) by nitroalkene fatty acids: importance of nitration position and degree ... J Med Chem. 2009 Aug 13;52(15):4631-9. DMJKOFW RU https://pubmed.ncbi.nlm.nih.gov/19719236 DMIPY3W DI DMIPY3W DMIPY3W DN (E)-5-octadecen-7,9-diynoic acid DMIPY3W MI TTPADOQ DMIPY3W MN HMG-CoA reductase (HMGCR) DMIPY3W MT DTT DMIPY3W MA Inhibitor DMIPY3W RN Novel Acetylenic Acids from the Root Bark of Paramacrolobium caeruleum: Inhibitors of 3-Hydroxy-3-methyl-glutaryl Coenzyme A Reductase J. Nat. Prod. 52(1):153-161 (1989). DMIPY3W RU http://pubs.acs.org/doi/abs/10.1021/np50061a020 DM1PCIX DI DM1PCIX DM1PCIX DN (E)-5-Styrylisatin DM1PCIX MI TT3WG5C DM1PCIX MN Monoamine oxidase type A (MAO-A) DM1PCIX MT DTT DM1PCIX MA Inhibitor DM1PCIX RN Inhibition of monoamine oxidase by (E)-styrylisatin analogues. Bioorg Med Chem Lett. 2009 May 1;19(9):2509-13. DM1PCIX RU https://pubmed.ncbi.nlm.nih.gov/19342233 DM1PCIX DI DM1PCIX DM1PCIX DN (E)-5-Styrylisatin DM1PCIX MI TTGP7BY DM1PCIX MN Monoamine oxidase type B (MAO-B) DM1PCIX MT DTT DM1PCIX MA Inhibitor DM1PCIX RN Inhibition of monoamine oxidase by (E)-styrylisatin analogues. Bioorg Med Chem Lett. 2009 May 1;19(9):2509-13. DM1PCIX RU https://pubmed.ncbi.nlm.nih.gov/19342233 DMACVNM DI DMACVNM DMACVNM DN (E)-6-Nitrooctadec-5-enoic Acid DMACVNM MI TTT2SVW DMACVNM MN PPAR-gamma messenger RNA (PPARG mRNA) DMACVNM MT DTT DMACVNM MA Inhibitor DMACVNM RN Activation of peroxisome proliferator-activated receptor gamma (PPARgamma) by nitroalkene fatty acids: importance of nitration position and degree ... J Med Chem. 2009 Aug 13;52(15):4631-9. DMACVNM RU https://pubmed.ncbi.nlm.nih.gov/19719236 DMG47QU DI DMG47QU DMG47QU DN (E)-6-Styrylisatin DMG47QU MI TTGP7BY DMG47QU MN Monoamine oxidase type B (MAO-B) DMG47QU MT DTT DMG47QU MA Inhibitor DMG47QU RN Inhibition of monoamine oxidase by (E)-styrylisatin analogues. Bioorg Med Chem Lett. 2009 May 1;19(9):2509-13. DMG47QU RU https://pubmed.ncbi.nlm.nih.gov/19342233 DMQT15Z DI DMQT15Z DMQT15Z DN (E)-8-(3-chlorostyryl)-caffeine DMQT15Z MI TTK25J1 DMQT15Z MN Adenosine A1 receptor (ADORA1) DMQT15Z MT DTT DMQT15Z MA Antagonist DMQT15Z RN Structure-activity relationships of 8-styrylxanthines as A2-selective adenosine antagonists. J Med Chem. 1993 May 14;36(10):1333-42. DMQT15Z RU https://pubmed.ncbi.nlm.nih.gov/8496902 DMQT15Z DI DMQT15Z DMQT15Z DN (E)-8-(3-chlorostyryl)-caffeine DMQT15Z MI TTNE7KG DMQT15Z MN Adenosine A2b receptor (ADORA2B) DMQT15Z MT DTT DMQT15Z MA Antagonist DMQT15Z RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 20). DMQT15Z RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=20 DMQT15Z DI DMQT15Z DMQT15Z DN (E)-8-(3-chlorostyryl)-caffeine DMQT15Z MI TTJFY5U DMQT15Z MN Adenosine A3 receptor (ADORA3) DMQT15Z MT DTT DMQT15Z MA Antagonist DMQT15Z RN A binding site model and structure-activity relationships for the rat A3 adenosine receptor. Mol Pharmacol. 1994 Jun;45(6):1101-11. DMQT15Z RU https://pubmed.ncbi.nlm.nih.gov/8022403 DMQT15Z DI DMQT15Z DMQT15Z DN (E)-8-(3-chlorostyryl)-caffeine DMQT15Z MI TTGP7BY DMQT15Z MN Monoamine oxidase type B (MAO-B) DMQT15Z MT DTT DMQT15Z MA Inhibitor DMQT15Z RN Synthesis and in vitro evaluation of pteridine analogues as monoamine oxidase B and nitric oxide synthase inhibitors. Bioorg Med Chem. 2009 Nov 1;17(21):7523-30. DMQT15Z RU https://pubmed.ncbi.nlm.nih.gov/19804982 DM5LSY9 DI DM5LSY9 DM5LSY9 DN (E)-8-Biphenyl-4-yl-1-oxazol-2-yl-oct-7-en-1-one DM5LSY9 MI TTBH0VX DM5LSY9 MN Histone deacetylase (HDAC) DM5LSY9 MT DTT DM5LSY9 MA Inhibitor DM5LSY9 RN Heterocyclic ketones as inhibitors of histone deacetylase. Bioorg Med Chem Lett. 2003 Nov 17;13(22):3909-13. DM5LSY9 RU https://pubmed.ncbi.nlm.nih.gov/14592473 DM5LSY9 DI DM5LSY9 DM5LSY9 DN (E)-8-Biphenyl-4-yl-1-oxazol-2-yl-oct-7-en-1-one DM5LSY9 MI TT6R7JZ DM5LSY9 MN Histone deacetylase 1 (HDAC1) DM5LSY9 MT DTT DM5LSY9 MA Inhibitor DM5LSY9 RN Heterocyclic ketones as inhibitors of histone deacetylase. Bioorg Med Chem Lett. 2003 Nov 17;13(22):3909-13. DM5LSY9 RU https://pubmed.ncbi.nlm.nih.gov/14592473 DM5LSY9 DI DM5LSY9 DM5LSY9 DN (E)-8-Biphenyl-4-yl-1-oxazol-2-yl-oct-7-en-1-one DM5LSY9 MI TTYHPU6 DM5LSY9 MN Histone deacetylase 10 (HDAC10) DM5LSY9 MT DTT DM5LSY9 MA Inhibitor DM5LSY9 RN Heterocyclic ketones as inhibitors of histone deacetylase. Bioorg Med Chem Lett. 2003 Nov 17;13(22):3909-13. DM5LSY9 RU https://pubmed.ncbi.nlm.nih.gov/14592473 DM5LSY9 DI DM5LSY9 DM5LSY9 DN (E)-8-Biphenyl-4-yl-1-oxazol-2-yl-oct-7-en-1-one DM5LSY9 MI TTSHTOI DM5LSY9 MN Histone deacetylase 2 (HDAC2) DM5LSY9 MT DTT DM5LSY9 MA Inhibitor DM5LSY9 RN Heterocyclic ketones as inhibitors of histone deacetylase. Bioorg Med Chem Lett. 2003 Nov 17;13(22):3909-13. DM5LSY9 RU https://pubmed.ncbi.nlm.nih.gov/14592473 DM5LSY9 DI DM5LSY9 DM5LSY9 DN (E)-8-Biphenyl-4-yl-1-oxazol-2-yl-oct-7-en-1-one DM5LSY9 MI TTTQGH8 DM5LSY9 MN Histone deacetylase 4 (HDAC4) DM5LSY9 MT DTT DM5LSY9 MA Inhibitor DM5LSY9 RN Heterocyclic ketones as inhibitors of histone deacetylase. Bioorg Med Chem Lett. 2003 Nov 17;13(22):3909-13. DM5LSY9 RU https://pubmed.ncbi.nlm.nih.gov/14592473 DM5LSY9 DI DM5LSY9 DM5LSY9 DN (E)-8-Biphenyl-4-yl-1-oxazol-2-yl-oct-7-en-1-one DM5LSY9 MI TT5ZKDI DM5LSY9 MN Histone deacetylase 6 (HDAC6) DM5LSY9 MT DTT DM5LSY9 MA Inhibitor DM5LSY9 RN Heterocyclic ketones as inhibitors of histone deacetylase. Bioorg Med Chem Lett. 2003 Nov 17;13(22):3909-13. DM5LSY9 RU https://pubmed.ncbi.nlm.nih.gov/14592473 DM5LSY9 DI DM5LSY9 DM5LSY9 DN (E)-8-Biphenyl-4-yl-1-oxazol-2-yl-oct-7-en-1-one DM5LSY9 MI TTT6LFV DM5LSY9 MN Histone deacetylase 8 (HDAC8) DM5LSY9 MT DTT DM5LSY9 MA Inhibitor DM5LSY9 RN Heterocyclic ketones as inhibitors of histone deacetylase. Bioorg Med Chem Lett. 2003 Nov 17;13(22):3909-13. DM5LSY9 RU https://pubmed.ncbi.nlm.nih.gov/14592473 DMULW35 DI DMULW35 DMULW35 DN (E)-9-Nitrohexadec-9-enoicAcid DMULW35 MI TTT2SVW DMULW35 MN PPAR-gamma messenger RNA (PPARG mRNA) DMULW35 MT DTT DMULW35 MA Inhibitor DMULW35 RN Activation of peroxisome proliferator-activated receptor gamma (PPARgamma) by nitroalkene fatty acids: importance of nitration position and degree ... J Med Chem. 2009 Aug 13;52(15):4631-9. DMULW35 RU https://pubmed.ncbi.nlm.nih.gov/19719236 DMWC2F9 DI DMWC2F9 DMWC2F9 DN (E)-9-nitrooctadec-9-enoic acid DMWC2F9 MI TTT2SVW DMWC2F9 MN PPAR-gamma messenger RNA (PPARG mRNA) DMWC2F9 MT DTT DMWC2F9 MA Inhibitor DMWC2F9 RN Activation of peroxisome proliferator-activated receptor gamma (PPARgamma) by nitroalkene fatty acids: importance of nitration position and degree ... J Med Chem. 2009 Aug 13;52(15):4631-9. DMWC2F9 RU https://pubmed.ncbi.nlm.nih.gov/19719236 DM9WHD2 DI DM9WHD2 DM9WHD2 DN (E)-N-(3,5-dimethoxyphenethyl)undec-2-enamide DM9WHD2 MI TT6OEDT DM9WHD2 MN Cannabinoid receptor 1 (CB1) DM9WHD2 MT DTT DM9WHD2 MA Inhibitor DM9WHD2 RN New metabolically stable fatty acid amide ligands of cannabinoid receptors: Synthesis and receptor affinity studies. Bioorg Med Chem Lett. 2006 Jan 1;16(1):138-41. DM9WHD2 RU https://pubmed.ncbi.nlm.nih.gov/16213718 DM9WHD2 DI DM9WHD2 DM9WHD2 DN (E)-N-(3,5-dimethoxyphenethyl)undec-2-enamide DM9WHD2 MI TTMSFAW DM9WHD2 MN Cannabinoid receptor 2 (CB2) DM9WHD2 MT DTT DM9WHD2 MA Inhibitor DM9WHD2 RN New metabolically stable fatty acid amide ligands of cannabinoid receptors: Synthesis and receptor affinity studies. Bioorg Med Chem Lett. 2006 Jan 1;16(1):138-41. DM9WHD2 RU https://pubmed.ncbi.nlm.nih.gov/16213718 DMW3RJL DI DMW3RJL DMW3RJL DN (E)-N-(3-iodoprop-2-enyl)-2beta-carbomethoxy-3beta-(4'-methylphenyl)n DMW3RJL MI TT8DBY3 DMW3RJL MN Angiotensin II receptor type-1 (AGTR1) DMW3RJL MT DTT DMW3RJL MA Antagonist DMW3RJL RN Pharmacological characterization of (E)-N-(3-iodoprop-2-enyl)-2beta-carbomethoxy-3beta-(4'-methylphenyl)n ortropane as a selective and potent inhibitor of the neuronal dopamine transporter. J Pharmacol Exp Ther. 1999 Nov;291(2):648-54. DMW3RJL RU https://pubmed.ncbi.nlm.nih.gov/10525084 DML6PJD DI DML6PJD DML6PJD DN (E)-N-(4-methoxyphenethyl)undec-2-enamide DML6PJD MI TT6OEDT DML6PJD MN Cannabinoid receptor 1 (CB1) DML6PJD MT DTT DML6PJD MA Inhibitor DML6PJD RN New metabolically stable fatty acid amide ligands of cannabinoid receptors: Synthesis and receptor affinity studies. Bioorg Med Chem Lett. 2006 Jan 1;16(1):138-41. DML6PJD RU https://pubmed.ncbi.nlm.nih.gov/16213718 DML6PJD DI DML6PJD DML6PJD DN (E)-N-(4-methoxyphenethyl)undec-2-enamide DML6PJD MI TTMSFAW DML6PJD MN Cannabinoid receptor 2 (CB2) DML6PJD MT DTT DML6PJD MA Inhibitor DML6PJD RN New metabolically stable fatty acid amide ligands of cannabinoid receptors: Synthesis and receptor affinity studies. Bioorg Med Chem Lett. 2006 Jan 1;16(1):138-41. DML6PJD RU https://pubmed.ncbi.nlm.nih.gov/16213718 DM1PCEM DI DM1PCEM DM1PCEM DN (E)-N-(4-methoxyphenyl)undec-2-enamide DM1PCEM MI TT6OEDT DM1PCEM MN Cannabinoid receptor 1 (CB1) DM1PCEM MT DTT DM1PCEM MA Inhibitor DM1PCEM RN New metabolically stable fatty acid amide ligands of cannabinoid receptors: Synthesis and receptor affinity studies. Bioorg Med Chem Lett. 2006 Jan 1;16(1):138-41. DM1PCEM RU https://pubmed.ncbi.nlm.nih.gov/16213718 DM1PCEM DI DM1PCEM DM1PCEM DN (E)-N-(4-methoxyphenyl)undec-2-enamide DM1PCEM MI TTMSFAW DM1PCEM MN Cannabinoid receptor 2 (CB2) DM1PCEM MT DTT DM1PCEM MA Inhibitor DM1PCEM RN New metabolically stable fatty acid amide ligands of cannabinoid receptors: Synthesis and receptor affinity studies. Bioorg Med Chem Lett. 2006 Jan 1;16(1):138-41. DM1PCEM RU https://pubmed.ncbi.nlm.nih.gov/16213718 DM7XIH3 DI DM7XIH3 DM7XIH3 DN (E)-N-(4-Phenylthiazol-2-yl) cinnamamide DM7XIH3 MI TTVDSZ0 DM7XIH3 MN Poly [ADP-ribose] polymerase 1 (PARP1) DM7XIH3 MT DTT DM7XIH3 MA Inhibitor DM7XIH3 RN Design, synthesis, and cytoprotective effect of 2-aminothiazole analogues as potent poly(ADP-ribose) polymerase-1 inhibitors. J Med Chem. 2009 Feb 12;52(3):718-25. DM7XIH3 RU https://pubmed.ncbi.nlm.nih.gov/19125579 DMHKXPM DI DMHKXPM DMHKXPM DN (E)-N-(6-(prop-1-enyl)-1H-indazol-3-yl)butyramide DMHKXPM MI TTRSMW9 DMHKXPM MN Glycogen synthase kinase-3 beta (GSK-3B) DMHKXPM MT DTT DMHKXPM MA Inhibitor DMHKXPM RN Rational design of potent GSK3beta inhibitors with selectivity for Cdk1 and Cdk2. Bioorg Med Chem Lett. 2010 Mar 15;20(6):1985-9. DMHKXPM RU https://pubmed.ncbi.nlm.nih.gov/20167481 DMXYAIQ DI DMXYAIQ DMXYAIQ DN (E)-Octadec-9-enal DMXYAIQ MI TTMI6F5 DMXYAIQ MN Transient receptor potential cation channel V1 (TRPV1) DMXYAIQ MT DTT DMXYAIQ MA Inhibitor DMXYAIQ RN The taming of capsaicin. Reversal of the vanilloid activity of N-acylvanillamines by aromatic iodination. J Med Chem. 2005 Jul 14;48(14):4663-9. DMXYAIQ RU https://pubmed.ncbi.nlm.nih.gov/16000002 DMP7TK0 DI DMP7TK0 DMP7TK0 DN (E)-Octadec-9-enoic acid phenylamide DMP7TK0 MI TTMF541 DMP7TK0 MN Liver carboxylesterase (CES1) DMP7TK0 MT DTT DMP7TK0 MA Inhibitor DMP7TK0 RN Acyl-CoA: cholesterol acyltransferase inhibitory activities of fatty acid amides isolated from Mylabris phalerate Pallas. Bioorg Med Chem Lett. 2004 Aug 16;14(16):4277-80. DMP7TK0 RU https://pubmed.ncbi.nlm.nih.gov/15261286 DMBLGF6 DI DMBLGF6 DMBLGF6 DN (E)-octadecan-9-ynoic acid DMBLGF6 MI TTPADOQ DMBLGF6 MN HMG-CoA reductase (HMGCR) DMBLGF6 MT DTT DMBLGF6 MA Inhibitor DMBLGF6 RN Novel Acetylenic Acids from the Root Bark of Paramacrolobium caeruleum: Inhibitors of 3-Hydroxy-3-methyl-glutaryl Coenzyme A Reductase J. Nat. Prod. 52(1):153-161 (1989). DMBLGF6 RU http://pubs.acs.org/doi/abs/10.1021/np50061a020 DMWU17O DI DMWU17O DMWU17O DN (E,E)-1,7-Diphenyl-4,6-heptadien-3-one DMWU17O MI TT50QJ3 DMWU17O MN Influenza Neuraminidase (Influ NA) DMWU17O MT DTT DMWU17O MA Inhibitor DMWU17O RN Antiviral potential and molecular insight into neuraminidase inhibiting diarylheptanoids from Alpinia katsumadai. J Med Chem. 2010 Jan 28;53(2):778-86. DMWU17O RU https://pubmed.ncbi.nlm.nih.gov/20014777 DMBIV6M DI DMBIV6M DMBIV6M DN (E,E)-5-Hydroxy-1,7-diphenyl-4,6-heptadien-3-one DMBIV6M MI TT50QJ3 DMBIV6M MN Influenza Neuraminidase (Influ NA) DMBIV6M MT DTT DMBIV6M MA Inhibitor DMBIV6M RN Antiviral potential and molecular insight into neuraminidase inhibiting diarylheptanoids from Alpinia katsumadai. J Med Chem. 2010 Jan 28;53(2):778-86. DMBIV6M RU https://pubmed.ncbi.nlm.nih.gov/20014777 DMPIUKZ DI DMPIUKZ DMPIUKZ DN (E,E)-8-(4-Phenylbutadien-1-yl)caffeine DMPIUKZ MI TTM2AOE DMPIUKZ MN Adenosine A2a receptor (ADORA2A) DMPIUKZ MT DTT DMPIUKZ MA Inhibitor DMPIUKZ RN Dual inhibition of monoamine oxidase B and antagonism of the adenosine A(2A) receptor by (E,E)-8-(4-phenylbutadien-1-yl)caffeine analogues. Bioorg Med Chem. 2008 Sep 15;16(18):8676-84. DMPIUKZ RU https://pubmed.ncbi.nlm.nih.gov/18723354 DMPEV7S DI DMPEV7S DMPEV7S DN (E,E)-8-[4-(3-Bromophenyl)butadien-1-yl]caffeine DMPEV7S MI TTM2AOE DMPEV7S MN Adenosine A2a receptor (ADORA2A) DMPEV7S MT DTT DMPEV7S MA Inhibitor DMPEV7S RN Dual inhibition of monoamine oxidase B and antagonism of the adenosine A(2A) receptor by (E,E)-8-(4-phenylbutadien-1-yl)caffeine analogues. Bioorg Med Chem. 2008 Sep 15;16(18):8676-84. DMPEV7S RU https://pubmed.ncbi.nlm.nih.gov/18723354 DMY4W25 DI DMY4W25 DMY4W25 DN (E,E)-8-[4-(3-Chlorophenyl)butadien-1-yl]caffeine DMY4W25 MI TTM2AOE DMY4W25 MN Adenosine A2a receptor (ADORA2A) DMY4W25 MT DTT DMY4W25 MA Inhibitor DMY4W25 RN Dual inhibition of monoamine oxidase B and antagonism of the adenosine A(2A) receptor by (E,E)-8-(4-phenylbutadien-1-yl)caffeine analogues. Bioorg Med Chem. 2008 Sep 15;16(18):8676-84. DMY4W25 RU https://pubmed.ncbi.nlm.nih.gov/18723354 DMPHJO2 DI DMPHJO2 DMPHJO2 DN (E,E)-8-[4-(3-Fluorophenyl)butadien-1-yl]caffeine DMPHJO2 MI TTM2AOE DMPHJO2 MN Adenosine A2a receptor (ADORA2A) DMPHJO2 MT DTT DMPHJO2 MA Inhibitor DMPHJO2 RN Dual inhibition of monoamine oxidase B and antagonism of the adenosine A(2A) receptor by (E,E)-8-(4-phenylbutadien-1-yl)caffeine analogues. Bioorg Med Chem. 2008 Sep 15;16(18):8676-84. DMPHJO2 RU https://pubmed.ncbi.nlm.nih.gov/18723354 DMVKJ0H DI DMVKJ0H DMVKJ0H DN (H-261)Boc-His-Pro-Phe-His-Leu(OH)-Val-Ile-His-OH DMVKJ0H MI TTB2MXP DMVKJ0H MN Angiotensinogenase renin (REN) DMVKJ0H MT DTT DMVKJ0H MA Inhibitor DMVKJ0H RN Renin inhibitors. Dipeptide analogues of angiotensinogen incorporating transition-state, nonpeptidic replacements at the scissile bond. J Med Chem. 1987 Oct;30(10):1729-37. DMVKJ0H RU https://pubmed.ncbi.nlm.nih.gov/3309313 DMSCQ64 DI DMSCQ64 DMSCQ64 DN (H-Dmt-Tic-Glu-NH-(CH(2))(5)-CO-Dap(6DMN)-NH(2) DMSCQ64 MI TT27RFC DMSCQ64 MN Opioid receptor delta (OPRD1) DMSCQ64 MT DTT DMSCQ64 MA Inhibitor DMSCQ64 RN 6-N,N-dimethylamino-2,3-naphthalimide: a new environment-sensitive fluorescent probe in delta- and mu-selective opioid peptides. J Med Chem. 2006 Jun 15;49(12):3653-8. DMSCQ64 RU https://pubmed.ncbi.nlm.nih.gov/16759107 DMSCQ64 DI DMSCQ64 DMSCQ64 DN (H-Dmt-Tic-Glu-NH-(CH(2))(5)-CO-Dap(6DMN)-NH(2) DMSCQ64 MI TTKWM86 DMSCQ64 MN Opioid receptor mu (MOP) DMSCQ64 MT DTT DMSCQ64 MA Inhibitor DMSCQ64 RN 6-N,N-dimethylamino-2,3-naphthalimide: a new environment-sensitive fluorescent probe in delta- and mu-selective opioid peptides. J Med Chem. 2006 Jun 15;49(12):3653-8. DMSCQ64 RU https://pubmed.ncbi.nlm.nih.gov/16759107 DMY6FUD DI DMY6FUD DMY6FUD DN (Hydroxyethyloxy)Tri(Ethyloxy)Octane DMY6FUD MI TTXMY0J DMY6FUD MN Pancreatic triacylglycerol lipase (PNLIP) DMY6FUD MT DTT DMY6FUD MA Inhibitor DMY6FUD RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMY6FUD RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMY6FUD DI DMY6FUD DMY6FUD DN (Hydroxyethyloxy)Tri(Ethyloxy)Octane DMY6FUD MI TTH0KSX DMY6FUD MN Rhodopsin (RHO) DMY6FUD MT DTT DMY6FUD MA Inhibitor DMY6FUD RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMY6FUD RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMOJUEC DI DMOJUEC DMOJUEC DN (hydroxymethylphenyl)agomelatine DMOJUEC MI TT0WAIE DMOJUEC MN Melatonin receptor type 1A (MTNR1A) DMOJUEC MT DTT DMOJUEC MA Antagonist DMOJUEC RN Synthesis of 3-phenylnaphthalenic derivatives as new selective MT(2) melatoninergic ligands. Bioorg Med Chem. 2008 Sep 15;16(18):8339-48. DMOJUEC RU https://pubmed.ncbi.nlm.nih.gov/18778943 DMP9ZVQ DI DMP9ZVQ DMP9ZVQ DN (L)-Phe-(D)-Phe-NH2 DMP9ZVQ MI TTZPO1L DMP9ZVQ MN Substance-P receptor (TACR1) DMP9ZVQ MT DTT DMP9ZVQ MA Inhibitor DMP9ZVQ RN Discovery of dipeptides with high affinity to the specific binding site for substance P1-7. J Med Chem. 2010 Mar 25;53(6):2383-9. DMP9ZVQ RU https://pubmed.ncbi.nlm.nih.gov/20178322 DMDUN83 DI DMDUN83 DMDUN83 DN (L-)-S-adenosyl-L-homocysteine DMDUN83 MI TTHVCUP DMDUN83 MN DNA [cytosine-5]-methyltransferase (DNMT) DMDUN83 MT DTT DMDUN83 MA Inhibitor DMDUN83 RN Constrained (l-)-S-adenosyl-l-homocysteine (SAH) analogues as DNA methyltransferase inhibitors. Bioorg Med Chem Lett. 2009 May 15;19(10):2742-6. DMDUN83 RU https://pubmed.ncbi.nlm.nih.gov/19364644 DMDUN83 DI DMDUN83 DMDUN83 DN (L-)-S-adenosyl-L-homocysteine DMDUN83 MI TT6VZ78 DMDUN83 MN DNA [cytosine-5]-methyltransferase 3B (DNMT3B) DMDUN83 MT DTT DMDUN83 MA Inhibitor DMDUN83 RN Constrained (l-)-S-adenosyl-l-homocysteine (SAH) analogues as DNA methyltransferase inhibitors. Bioorg Med Chem Lett. 2009 May 15;19(10):2742-6. DMDUN83 RU https://pubmed.ncbi.nlm.nih.gov/19364644 DMDUN83 DI DMDUN83 DMDUN83 DN (L-)-S-adenosyl-L-homocysteine DMDUN83 MI TT2B6EV DMDUN83 MN Histamine N-methyltransferase (HNMT) DMDUN83 MT DTT DMDUN83 MA Inhibitor DMDUN83 RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMDUN83 RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMRGIF3 DI DMRGIF3 DMRGIF3 DN (LTB4-(Csa)4)2-Glu-H Conjugate DMRGIF3 MI TTN53ZF DMRGIF3 MN Leukotriene B4 receptor 1 (LTB4R) DMRGIF3 MT DTT DMRGIF3 MA Inhibitor DMRGIF3 RN Synthesis of leukotriene B4 antagonists labeled with In-111 or Tc-99m to image infectious and inflammatory foci. J Med Chem. 2005 Oct 6;48(20):6442-53. DMRGIF3 RU https://pubmed.ncbi.nlm.nih.gov/16190770 DM9ATZ8 DI DM9ATZ8 DM9ATZ8 DN (N-(3-phenoxycinnamyl)-acetohydroxamic acid DM9ATZ8 MI TTSJ6Q4 DM9ATZ8 MN LOX-5 messenger RNA (ALOX5 mRNA) DM9ATZ8 MT DTT DM9ATZ8 MA Inhibitor DM9ATZ8 RN Structural optimization and biological evaluation of 2-substituted 5-hydroxyindole-3-carboxylates as potent inhibitors of human 5-lipoxygenase. J Med Chem. 2009 Jun 11;52(11):3474-83. DM9ATZ8 RU https://pubmed.ncbi.nlm.nih.gov/19492852 DM6SV7I DI DM6SV7I DM6SV7I DN (N)methanocarba-UTP DM6SV7I MI TT24DGP DM6SV7I MN P2Y purinoceptor 4 (P2RY4) DM6SV7I MT DTT DM6SV7I MA Agonist DM6SV7I RN Methanocarba modification of uracil and adenine nucleotides: high potency of Northern ring conformation at P2Y1, P2Y2, P2Y4, and P2Y11 but not P2Y6 receptors. J Med Chem. 2002 Jan 3;45(1):208-18. DM6SV7I RU https://pubmed.ncbi.nlm.nih.gov/11754592 DMPYK1T DI DMPYK1T DMPYK1T DN (O10eq)-Benzyloxycarbonyl-beta-alanylryanodine DMPYK1T MI TTU5CIX DMPYK1T MN Ryanodine receptor 1 (RYR1) DMPYK1T MT DTT DMPYK1T MA Inhibitor DMPYK1T RN Amino- and guanidinoacylryanodines: basic ryanodine esters with enhanced affinity for the sarcoplasmic reticulum Ca(2+)-release channel. J Med Chem. 1993 May 14;36(10):1319-23. DMPYK1T RU https://pubmed.ncbi.nlm.nih.gov/8388466 DMRSZGB DI DMRSZGB DMRSZGB DN (O10eq)-beta-alanyl-anhydro-ryanodine DMRSZGB MI TTU5CIX DMRSZGB MN Ryanodine receptor 1 (RYR1) DMRSZGB MT DTT DMRSZGB MA Inhibitor DMRSZGB RN Amino- and guanidinoacylryanodines: basic ryanodine esters with enhanced affinity for the sarcoplasmic reticulum Ca(2+)-release channel. J Med Chem. 1993 May 14;36(10):1319-23. DMRSZGB RU https://pubmed.ncbi.nlm.nih.gov/8388466 DMVGARN DI DMVGARN DMVGARN DN (O10eq)-beta-alanylryanodine DMVGARN MI TTU5CIX DMVGARN MN Ryanodine receptor 1 (RYR1) DMVGARN MT DTT DMVGARN MA Inhibitor DMVGARN RN Amino- and guanidinoacylryanodines: basic ryanodine esters with enhanced affinity for the sarcoplasmic reticulum Ca(2+)-release channel. J Med Chem. 1993 May 14;36(10):1319-23. DMVGARN RU https://pubmed.ncbi.nlm.nih.gov/8388466 DMSV8XM DI DMSV8XM DMSV8XM DN (O10eq)-beta-guanidinopropionylryanodine DMSV8XM MI TTU5CIX DMSV8XM MN Ryanodine receptor 1 (RYR1) DMSV8XM MT DTT DMSV8XM MA Inhibitor DMSV8XM RN Amino- and guanidinoacylryanodines: basic ryanodine esters with enhanced affinity for the sarcoplasmic reticulum Ca(2+)-release channel. J Med Chem. 1993 May 14;36(10):1319-23. DMSV8XM RU https://pubmed.ncbi.nlm.nih.gov/8388466 DM97W5T DI DM97W5T DM97W5T DN (O10eq)-guanidino acetylryanodine DM97W5T MI TTU5CIX DM97W5T MN Ryanodine receptor 1 (RYR1) DM97W5T MT DTT DM97W5T MA Inhibitor DM97W5T RN Amino- and guanidinoacylryanodines: basic ryanodine esters with enhanced affinity for the sarcoplasmic reticulum Ca(2+)-release channel. J Med Chem. 1993 May 14;36(10):1319-23. DM97W5T RU https://pubmed.ncbi.nlm.nih.gov/8388466 DMB8NWI DI DMB8NWI DMB8NWI DN (P-Iodophenylacetylamino)Methylphosphinic Acid DMB8NWI MI TTHI19T DMB8NWI MN Staphylococcus Beta-lactamase (Stap-coc blaZ) DMB8NWI MT DTT DMB8NWI MA Inhibitor DMB8NWI RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMB8NWI RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMYJAM5 DI DMYJAM5 DMYJAM5 DN (R)-(-)-10-methyl-11-hydroxyaporphine DMYJAM5 MI TTSQIFT DMYJAM5 MN 5-HT 1A receptor (HTR1A) DMYJAM5 MT DTT DMYJAM5 MA Inhibitor DMYJAM5 RN R-(-)-N-alkyl-11-hydroxy-10-hydroxymethyl- and 10-methyl-aporphines as 5-HT1A receptor ligands. Bioorg Med Chem Lett. 2007 Aug 1;17(15):4128-30. DMYJAM5 RU https://pubmed.ncbi.nlm.nih.gov/17543523 DMYJAM5 DI DMYJAM5 DMYJAM5 DN (R)-(-)-10-methyl-11-hydroxyaporphine DMYJAM5 MI TTZFYLI DMYJAM5 MN Dopamine D1 receptor (D1R) DMYJAM5 MT DTT DMYJAM5 MA Inhibitor DMYJAM5 RN R-(-)-N-alkyl-11-hydroxy-10-hydroxymethyl- and 10-methyl-aporphines as 5-HT1A receptor ligands. Bioorg Med Chem Lett. 2007 Aug 1;17(15):4128-30. DMYJAM5 RU https://pubmed.ncbi.nlm.nih.gov/17543523 DMYJAM5 DI DMYJAM5 DMYJAM5 DN (R)-(-)-10-methyl-11-hydroxyaporphine DMYJAM5 MI TTEX248 DMYJAM5 MN Dopamine D2 receptor (D2R) DMYJAM5 MT DTT DMYJAM5 MA Inhibitor DMYJAM5 RN R-(-)-N-alkyl-11-hydroxy-10-hydroxymethyl- and 10-methyl-aporphines as 5-HT1A receptor ligands. Bioorg Med Chem Lett. 2007 Aug 1;17(15):4128-30. DMYJAM5 RU https://pubmed.ncbi.nlm.nih.gov/17543523 DMKB621 DI DMKB621 DMKB621 DN (R)-(-)-11-hydroxy-N-n-propylnoraporphine DMKB621 MI TTJQOD7 DMKB621 MN 5-HT 2A receptor (HTR2A) DMKB621 MT DTT DMKB621 MA Inhibitor DMKB621 RN N-Propylnoraporphin-11-O-yl carboxylic esters as potent dopamine D(2) and serotonin 5-HT(1A) receptor dual ligands. Bioorg Med Chem. 2008 Sep 15;16(18):8335-8. DMKB621 RU https://pubmed.ncbi.nlm.nih.gov/18783955 DMKB621 DI DMKB621 DMKB621 DN (R)-(-)-11-hydroxy-N-n-propylnoraporphine DMKB621 MI TTZFYLI DMKB621 MN Dopamine D1 receptor (D1R) DMKB621 MT DTT DMKB621 MA Inhibitor DMKB621 RN Synthesis and dopamine receptor affinities of N-alkyl-11-hydroxy-2-methoxynoraporphines: N-alkyl substituents determine D1 versus D2 receptor selec... J Med Chem. 2008 Feb 28;51(4):983-7. DMKB621 RU https://pubmed.ncbi.nlm.nih.gov/18251489 DMKB621 DI DMKB621 DMKB621 DN (R)-(-)-11-hydroxy-N-n-propylnoraporphine DMKB621 MI TTEX248 DMKB621 MN Dopamine D2 receptor (D2R) DMKB621 MT DTT DMKB621 MA Inhibitor DMKB621 RN Synthesis and dopamine receptor affinities of N-alkyl-11-hydroxy-2-methoxynoraporphines: N-alkyl substituents determine D1 versus D2 receptor selec... J Med Chem. 2008 Feb 28;51(4):983-7. DMKB621 RU https://pubmed.ncbi.nlm.nih.gov/18251489 DMQ2INJ DI DMQ2INJ DMQ2INJ DN (R)-(-)-2-methoxy-11-hydroxyaporphine DMQ2INJ MI TTZFYLI DMQ2INJ MN Dopamine D1 receptor (D1R) DMQ2INJ MT DTT DMQ2INJ MA Inhibitor DMQ2INJ RN Synthesis and dopamine receptor affinities of N-alkyl-11-hydroxy-2-methoxynoraporphines: N-alkyl substituents determine D1 versus D2 receptor selec... J Med Chem. 2008 Feb 28;51(4):983-7. DMQ2INJ RU https://pubmed.ncbi.nlm.nih.gov/18251489 DMQ2INJ DI DMQ2INJ DMQ2INJ DN (R)-(-)-2-methoxy-11-hydroxyaporphine DMQ2INJ MI TTEX248 DMQ2INJ MN Dopamine D2 receptor (D2R) DMQ2INJ MT DTT DMQ2INJ MA Inhibitor DMQ2INJ RN Synthesis and dopamine receptor affinities of N-alkyl-11-hydroxy-2-methoxynoraporphines: N-alkyl substituents determine D1 versus D2 receptor selec... J Med Chem. 2008 Feb 28;51(4):983-7. DMQ2INJ RU https://pubmed.ncbi.nlm.nih.gov/18251489 DMLXB62 DI DMLXB62 DMLXB62 DN (R)-(-)-2-methoxy-N-npropylnorapomorphine DMLXB62 MI TTZFYLI DMLXB62 MN Dopamine D1 receptor (D1R) DMLXB62 MT DTT DMLXB62 MA Inhibitor DMLXB62 RN Synthesis and dopamine receptor affinities of N-alkyl-11-hydroxy-2-methoxynoraporphines: N-alkyl substituents determine D1 versus D2 receptor selec... J Med Chem. 2008 Feb 28;51(4):983-7. DMLXB62 RU https://pubmed.ncbi.nlm.nih.gov/18251489 DMLXB62 DI DMLXB62 DMLXB62 DN (R)-(-)-2-methoxy-N-npropylnorapomorphine DMLXB62 MI TTEX248 DMLXB62 MN Dopamine D2 receptor (D2R) DMLXB62 MT DTT DMLXB62 MA Inhibitor DMLXB62 RN Synthesis and dopamine receptor affinities of N-alkyl-11-hydroxy-2-methoxynoraporphines: N-alkyl substituents determine D1 versus D2 receptor selec... J Med Chem. 2008 Feb 28;51(4):983-7. DMLXB62 RU https://pubmed.ncbi.nlm.nih.gov/18251489 DMAYEJL DI DMAYEJL DMAYEJL DN (R)-(-)-2-Methyl-apomorphine hydrochloride DMAYEJL MI TTEX248 DMAYEJL MN Dopamine D2 receptor (D2R) DMAYEJL MT DTT DMAYEJL MA Inhibitor DMAYEJL RN Synthesis and neuropharmacological evaluation of 2-aryl- and alkylapomorphines. Bioorg Med Chem. 2008 Apr 1;16(7):3773-9. DMAYEJL RU https://pubmed.ncbi.nlm.nih.gov/18289859 DMAYEJL DI DMAYEJL DMAYEJL DN (R)-(-)-2-Methyl-apomorphine hydrochloride DMAYEJL MI TT4C8EA DMAYEJL MN Dopamine D3 receptor (D3R) DMAYEJL MT DTT DMAYEJL MA Inhibitor DMAYEJL RN Synthesis and neuropharmacological evaluation of 2-aryl- and alkylapomorphines. Bioorg Med Chem. 2008 Apr 1;16(7):3773-9. DMAYEJL RU https://pubmed.ncbi.nlm.nih.gov/18289859 DME62U0 DI DME62U0 DME62U0 DN (R)-(-)-2-Phenyl-apomorphine hydrochloride DME62U0 MI TTEX248 DME62U0 MN Dopamine D2 receptor (D2R) DME62U0 MT DTT DME62U0 MA Inhibitor DME62U0 RN Synthesis and neuropharmacological evaluation of 2-aryl- and alkylapomorphines. Bioorg Med Chem. 2008 Apr 1;16(7):3773-9. DME62U0 RU https://pubmed.ncbi.nlm.nih.gov/18289859 DME62U0 DI DME62U0 DME62U0 DN (R)-(-)-2-Phenyl-apomorphine hydrochloride DME62U0 MI TT4C8EA DME62U0 MN Dopamine D3 receptor (D3R) DME62U0 MT DTT DME62U0 MA Inhibitor DME62U0 RN Synthesis and neuropharmacological evaluation of 2-aryl- and alkylapomorphines. Bioorg Med Chem. 2008 Apr 1;16(7):3773-9. DME62U0 RU https://pubmed.ncbi.nlm.nih.gov/18289859 DMPSEZV DI DMPSEZV DMPSEZV DN (R)-(-)-N-ethyl-2-methoxy-11-hydroxynoraporphine DMPSEZV MI TTZFYLI DMPSEZV MN Dopamine D1 receptor (D1R) DMPSEZV MT DTT DMPSEZV MA Inhibitor DMPSEZV RN Synthesis and dopamine receptor affinities of N-alkyl-11-hydroxy-2-methoxynoraporphines: N-alkyl substituents determine D1 versus D2 receptor selec... J Med Chem. 2008 Feb 28;51(4):983-7. DMPSEZV RU https://pubmed.ncbi.nlm.nih.gov/18251489 DMPSEZV DI DMPSEZV DMPSEZV DN (R)-(-)-N-ethyl-2-methoxy-11-hydroxynoraporphine DMPSEZV MI TTEX248 DMPSEZV MN Dopamine D2 receptor (D2R) DMPSEZV MT DTT DMPSEZV MA Inhibitor DMPSEZV RN Synthesis and dopamine receptor affinities of N-alkyl-11-hydroxy-2-methoxynoraporphines: N-alkyl substituents determine D1 versus D2 receptor selec... J Med Chem. 2008 Feb 28;51(4):983-7. DMPSEZV RU https://pubmed.ncbi.nlm.nih.gov/18251489 DM48SML DI DM48SML DM48SML DN (R)-(-)-N-propyl-2-methoxy-11-hydroxynoraporphine DM48SML MI TTZFYLI DM48SML MN Dopamine D1 receptor (D1R) DM48SML MT DTT DM48SML MA Inhibitor DM48SML RN Synthesis and dopamine receptor affinities of N-alkyl-11-hydroxy-2-methoxynoraporphines: N-alkyl substituents determine D1 versus D2 receptor selec... J Med Chem. 2008 Feb 28;51(4):983-7. DM48SML RU https://pubmed.ncbi.nlm.nih.gov/18251489 DM48SML DI DM48SML DM48SML DN (R)-(-)-N-propyl-2-methoxy-11-hydroxynoraporphine DM48SML MI TTEX248 DM48SML MN Dopamine D2 receptor (D2R) DM48SML MT DTT DM48SML MA Inhibitor DM48SML RN Synthesis and dopamine receptor affinities of N-alkyl-11-hydroxy-2-methoxynoraporphines: N-alkyl substituents determine D1 versus D2 receptor selec... J Med Chem. 2008 Feb 28;51(4):983-7. DM48SML RU https://pubmed.ncbi.nlm.nih.gov/18251489 DM9DBHU DI DM9DBHU DM9DBHU DN (R)-(+)-(4,5,6-trimethoxyindan-1-yl)methanamine DM9DBHU MI TTJQOD7 DM9DBHU MN 5-HT 2A receptor (HTR2A) DM9DBHU MT DTT DM9DBHU MA Inhibitor DM9DBHU RN C-(4,5,6-trimethoxyindan-1-yl)methanamine: a mescaline analogue designed using a homology model of the 5-HT2A receptor. J Med Chem. 2006 Jul 13;49(14):4269-74. DM9DBHU RU https://pubmed.ncbi.nlm.nih.gov/16821786 DM5UOFY DI DM5UOFY DM5UOFY DN (R)(+)-2-(4-fluorophenyl)-7-methoxychroman-4-one DM5UOFY MI TTGP7BY DM5UOFY MN Monoamine oxidase type B (MAO-B) DM5UOFY MT DTT DM5UOFY MA Inhibitor DM5UOFY RN A new series of flavones, thioflavones, and flavanones as selective monoamine oxidase-B inhibitors. Bioorg Med Chem. 2010 Feb;18(3):1273-9. DM5UOFY RU https://pubmed.ncbi.nlm.nih.gov/20045650 DM6WTLZ DI DM6WTLZ DM6WTLZ DN (R)(+)-7-fluoro-2-(4-fluorophenyl)chroman-4-one DM6WTLZ MI TTGP7BY DM6WTLZ MN Monoamine oxidase type B (MAO-B) DM6WTLZ MT DTT DM6WTLZ MA Inhibitor DM6WTLZ RN A new series of flavones, thioflavones, and flavanones as selective monoamine oxidase-B inhibitors. Bioorg Med Chem. 2010 Feb;18(3):1273-9. DM6WTLZ RU https://pubmed.ncbi.nlm.nih.gov/20045650 DMJCN0Y DI DMJCN0Y DMJCN0Y DN (R)(+)-7-fluoro-2-phenylchroman-4-one DMJCN0Y MI TTGP7BY DMJCN0Y MN Monoamine oxidase type B (MAO-B) DMJCN0Y MT DTT DMJCN0Y MA Inhibitor DMJCN0Y RN A new series of flavones, thioflavones, and flavanones as selective monoamine oxidase-B inhibitors. Bioorg Med Chem. 2010 Feb;18(3):1273-9. DMJCN0Y RU https://pubmed.ncbi.nlm.nih.gov/20045650 DMHNKWR DI DMHNKWR DMHNKWR DN (R)(+)-7-fluoro-2-p-tolylchroman-4-one DMHNKWR MI TTGP7BY DMHNKWR MN Monoamine oxidase type B (MAO-B) DMHNKWR MT DTT DMHNKWR MA Inhibitor DMHNKWR RN A new series of flavones, thioflavones, and flavanones as selective monoamine oxidase-B inhibitors. Bioorg Med Chem. 2010 Feb;18(3):1273-9. DMHNKWR RU https://pubmed.ncbi.nlm.nih.gov/20045650 DM8ZHYR DI DM8ZHYR DM8ZHYR DN (R)(+)-7-methyl-2-phenylchroman-4-one DM8ZHYR MI TTGP7BY DM8ZHYR MN Monoamine oxidase type B (MAO-B) DM8ZHYR MT DTT DM8ZHYR MA Inhibitor DM8ZHYR RN A new series of flavones, thioflavones, and flavanones as selective monoamine oxidase-B inhibitors. Bioorg Med Chem. 2010 Feb;18(3):1273-9. DM8ZHYR RU https://pubmed.ncbi.nlm.nih.gov/20045650 DMVN50D DI DMVN50D DMVN50D DN (R)(+)-7-methyl-2-p-tolylchroman-4-one DMVN50D MI TTGP7BY DMVN50D MN Monoamine oxidase type B (MAO-B) DMVN50D MT DTT DMVN50D MA Inhibitor DMVN50D RN A new series of flavones, thioflavones, and flavanones as selective monoamine oxidase-B inhibitors. Bioorg Med Chem. 2010 Feb;18(3):1273-9. DMVN50D RU https://pubmed.ncbi.nlm.nih.gov/20045650 DM7C148 DI DM7C148 DM7C148 DN (R)-(+)-coclaurine DM7C148 MI TTZFYLI DM7C148 MN Dopamine D1 receptor (D1R) DM7C148 MT DTT DM7C148 MA Inhibitor DM7C148 RN Synthesis and dopamine receptor selectivity of the benzyltetrahydroisoquinoline, (R)-(+)-nor-roefractine. J Nat Prod. 1998 Jun 26;61(6):709-12. DM7C148 RU https://pubmed.ncbi.nlm.nih.gov/9644051 DM7C148 DI DM7C148 DM7C148 DN (R)-(+)-coclaurine DM7C148 MI TTEX248 DM7C148 MN Dopamine D2 receptor (D2R) DM7C148 MT DTT DM7C148 MA Inhibitor DM7C148 RN Synthesis and dopamine receptor selectivity of the benzyltetrahydroisoquinoline, (R)-(+)-nor-roefractine. J Nat Prod. 1998 Jun 26;61(6):709-12. DM7C148 RU https://pubmed.ncbi.nlm.nih.gov/9644051 DMBXRKS DI DMBXRKS DMBXRKS DN (R)-1-((S)-morpholin-2-yl)-1,2-diphenylethanol DMBXRKS MI TTAWNKZ DMBXRKS MN Norepinephrine transporter (NET) DMBXRKS MT DTT DMBXRKS MA Inhibitor DMBXRKS RN Discovery of novel and selective tertiary alcohol containing inhibitors of the norepinephrine transporter. Bioorg Med Chem Lett. 2006 Apr 1;16(7):2022-5. DMBXRKS RU https://pubmed.ncbi.nlm.nih.gov/16413778 DMYBC24 DI DMYBC24 DMYBC24 DN (R)-1-(1H-indazol-4-yl)-3-(1-p-tolylethyl)urea DMYBC24 MI TTMI6F5 DMYBC24 MN Transient receptor potential cation channel V1 (TRPV1) DMYBC24 MT DTT DMYBC24 MA Inhibitor DMYBC24 RN Alpha-methylation at benzylic fragment of N-aryl-N'-benzyl ureas provides TRPV1 antagonists with better pharmacokinetic properties and higher effic... Bioorg Med Chem Lett. 2007 Jul 15;17(14):3894-9. DMYBC24 RU https://pubmed.ncbi.nlm.nih.gov/17507218 DMGD026 DI DMGD026 DMGD026 DN (R)-1-(2-aminoacetyl)pyrrolidin-2-ylboronic acid DMGD026 MI TTDIGC1 DMGD026 MN Dipeptidyl peptidase 4 (DPP-4) DMGD026 MT DTT DMGD026 MA Inhibitor DMGD026 RN Dipeptide boronic acid inhibitors of dipeptidyl peptidase IV: determinants of potency and in vivo efficacy and safety. J Med Chem. 2008 Oct 9;51(19):6005-13. DMGD026 RU https://pubmed.ncbi.nlm.nih.gov/18783201 DMMY0NF DI DMMY0NF DMMY0NF DN (R)-1-(2-methoxyphenethyl)-2-methylpyrrolidine DMMY0NF MI TT9JNIC DMMY0NF MN Histamine H3 receptor (H3R) DMMY0NF MT DTT DMMY0NF MA Inhibitor DMMY0NF RN In vitro SAR of pyrrolidine-containing histamine H3 receptor antagonists: trends across multiple chemical series. Bioorg Med Chem Lett. 2008 Jan 1;18(1):355-9. DMMY0NF RU https://pubmed.ncbi.nlm.nih.gov/18077160 DM76SZK DI DM76SZK DM76SZK DN (R)-1-(3-methoxyphenethyl)-2-methylpyrrolidine DM76SZK MI TT9JNIC DM76SZK MN Histamine H3 receptor (H3R) DM76SZK MT DTT DM76SZK MA Inhibitor DM76SZK RN In vitro SAR of pyrrolidine-containing histamine H3 receptor antagonists: trends across multiple chemical series. Bioorg Med Chem Lett. 2008 Jan 1;18(1):355-9. DM76SZK RU https://pubmed.ncbi.nlm.nih.gov/18077160 DMDC297 DI DMDC297 DMDC297 DN (R)-1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine DMDC297 MI TTJQOD7 DMDC297 MN 5-HT 2A receptor (HTR2A) DMDC297 MT DTT DMDC297 MA Inhibitor DMDC297 RN Novel benzodifuran analogs as potent 5-HT2A receptor agonists with ocular hypotensive activity. Bioorg Med Chem Lett. 2007 Jun 1;17(11):2998-3002. DMDC297 RU https://pubmed.ncbi.nlm.nih.gov/17419053 DMR3DSG DI DMR3DSG DMR3DSG DN (R)-1-(4-methoxyphenethyl)-2-methylpyrrolidine DMR3DSG MI TT9JNIC DMR3DSG MN Histamine H3 receptor (H3R) DMR3DSG MT DTT DMR3DSG MA Inhibitor DMR3DSG RN In vitro SAR of pyrrolidine-containing histamine H3 receptor antagonists: trends across multiple chemical series. Bioorg Med Chem Lett. 2008 Jan 1;18(1):355-9. DMR3DSG RU https://pubmed.ncbi.nlm.nih.gov/18077160 DMNROUV DI DMNROUV DMNROUV DN (R)-1-(4-nitrophenethyl)-2-methylpyrrolidine DMNROUV MI TT9JNIC DMNROUV MN Histamine H3 receptor (H3R) DMNROUV MT DTT DMNROUV MA Inhibitor DMNROUV RN In vitro SAR of pyrrolidine-containing histamine H3 receptor antagonists: trends across multiple chemical series. Bioorg Med Chem Lett. 2008 Jan 1;18(1):355-9. DMNROUV RU https://pubmed.ncbi.nlm.nih.gov/18077160 DMKJWMC DI DMKJWMC DMKJWMC DN (R)-11-Amino-2-methoxyaporphine DMKJWMC MI TTSQIFT DMKJWMC MN 5-HT 1A receptor (HTR1A) DMKJWMC MT DTT DMKJWMC MA Inhibitor DMKJWMC RN Synthesis and pharmacological investigation of novel 2-aminothiazole-privileged aporphines. Bioorg Med Chem. 2008 Jul 15;16(14):6675-81. DMKJWMC RU https://pubmed.ncbi.nlm.nih.gov/18562201 DMKJWMC DI DMKJWMC DMKJWMC DN (R)-11-Amino-2-methoxyaporphine DMKJWMC MI TTZFYLI DMKJWMC MN Dopamine D1 receptor (D1R) DMKJWMC MT DTT DMKJWMC MA Inhibitor DMKJWMC RN Synthesis and pharmacological investigation of novel 2-aminothiazole-privileged aporphines. Bioorg Med Chem. 2008 Jul 15;16(14):6675-81. DMKJWMC RU https://pubmed.ncbi.nlm.nih.gov/18562201 DMXUHV3 DI DMXUHV3 DMXUHV3 DN (R)-2-((4-benzylphenoxy)methyl)piperidine DMXUHV3 MI TTXZEAJ DMXUHV3 MN Leukotriene A-4 hydrolase (LTA4H) DMXUHV3 MT DTT DMXUHV3 MA Inhibitor DMXUHV3 RN Discovery of novel leukotriene A4 hydrolase inhibitors based on piperidine and piperazine scaffolds. Bioorg Med Chem Lett. 2010 May 1;20(9):2851-4. DMXUHV3 RU https://pubmed.ncbi.nlm.nih.gov/20371179 DM6KJ3D DI DM6KJ3D DM6KJ3D DN (R)-2-((4-phenoxyphenoxy)methyl)piperidine DM6KJ3D MI TTXZEAJ DM6KJ3D MN Leukotriene A-4 hydrolase (LTA4H) DM6KJ3D MT DTT DM6KJ3D MA Inhibitor DM6KJ3D RN Discovery of novel leukotriene A4 hydrolase inhibitors based on piperidine and piperazine scaffolds. Bioorg Med Chem Lett. 2010 May 1;20(9):2851-4. DM6KJ3D RU https://pubmed.ncbi.nlm.nih.gov/20371179 DMFDW4C DI DMFDW4C DMFDW4C DN (R)-2-(2-(2-methylpyrrolidin-1-yl)ethyl)phenol DMFDW4C MI TT9JNIC DMFDW4C MN Histamine H3 receptor (H3R) DMFDW4C MT DTT DMFDW4C MA Inhibitor DMFDW4C RN In vitro SAR of pyrrolidine-containing histamine H3 receptor antagonists: trends across multiple chemical series. Bioorg Med Chem Lett. 2008 Jan 1;18(1):355-9. DMFDW4C RU https://pubmed.ncbi.nlm.nih.gov/18077160 DM0L6ES DI DM0L6ES DM0L6ES DN (R)-2-(2-(2-methylpyrrolidin-1-yl)ethyl)pyridine DM0L6ES MI TT9JNIC DM0L6ES MN Histamine H3 receptor (H3R) DM0L6ES MT DTT DM0L6ES MA Inhibitor DM0L6ES RN In vitro SAR of pyrrolidine-containing histamine H3 receptor antagonists: trends across multiple chemical series. Bioorg Med Chem Lett. 2008 Jan 1;18(1):355-9. DM0L6ES RU https://pubmed.ncbi.nlm.nih.gov/18077160 DMVEMNA DI DMVEMNA DMVEMNA DN (R)-2-(2-naphthamido)-3-m-tolylpropanoic acid DMVEMNA MI TTJNTSI DMVEMNA MN Rotamase Pin1 (PIN1) DMVEMNA MT DTT DMVEMNA MA Inhibitor DMVEMNA RN Structure-based design of novel human Pin1 inhibitors (II). Bioorg Med Chem Lett. 2010 Apr 1;20(7):2210-4. DMVEMNA RU https://pubmed.ncbi.nlm.nih.gov/20207139 DMXGCYZ DI DMXGCYZ DMXGCYZ DN (R)-2-(2-naphthamido)-3-p-tolylpropanoic acid DMXGCYZ MI TTJNTSI DMXGCYZ MN Rotamase Pin1 (PIN1) DMXGCYZ MT DTT DMXGCYZ MA Inhibitor DMXGCYZ RN Structure-based design of novel human Pin1 inhibitors (II). Bioorg Med Chem Lett. 2010 Apr 1;20(7):2210-4. DMXGCYZ RU https://pubmed.ncbi.nlm.nih.gov/20207139 DM9WL6O DI DM9WL6O DM9WL6O DN (R)-2-(2-naphthamido)-5-phenylpent-4-ynoic acid DM9WL6O MI TTJNTSI DM9WL6O MN Rotamase Pin1 (PIN1) DM9WL6O MT DTT DM9WL6O MA Inhibitor DM9WL6O RN Structure-based design of novel human Pin1 inhibitors (II). Bioorg Med Chem Lett. 2010 Apr 1;20(7):2210-4. DM9WL6O RU https://pubmed.ncbi.nlm.nih.gov/20207139 DM74IWX DI DM74IWX DM74IWX DN (R)-2-(2-phenyl-2-(piperazin-1-yl)ethyl)phenol DM74IWX MI TTVBI8W DM74IWX MN Dopamine transporter (DAT) DM74IWX MT DTT DM74IWX MA Inhibitor DM74IWX RN Second generation N-(1,2-diphenylethyl)piperazines as dual serotonin and noradrenaline reuptake inhibitors: improving metabolic stability and reduc... Bioorg Med Chem Lett. 2010 Jun 15;20(12):3788-92. DM74IWX RU https://pubmed.ncbi.nlm.nih.gov/20471260 DM74IWX DI DM74IWX DM74IWX DN (R)-2-(2-phenyl-2-(piperazin-1-yl)ethyl)phenol DM74IWX MI TTAWNKZ DM74IWX MN Norepinephrine transporter (NET) DM74IWX MT DTT DM74IWX MA Inhibitor DM74IWX RN Second generation N-(1,2-diphenylethyl)piperazines as dual serotonin and noradrenaline reuptake inhibitors: improving metabolic stability and reduc... Bioorg Med Chem Lett. 2010 Jun 15;20(12):3788-92. DM74IWX RU https://pubmed.ncbi.nlm.nih.gov/20471260 DM74IWX DI DM74IWX DM74IWX DN (R)-2-(2-phenyl-2-(piperazin-1-yl)ethyl)phenol DM74IWX MI TT3ROYC DM74IWX MN Serotonin transporter (SERT) DM74IWX MT DTT DM74IWX MA Inhibitor DM74IWX RN Second generation N-(1,2-diphenylethyl)piperazines as dual serotonin and noradrenaline reuptake inhibitors: improving metabolic stability and reduc... Bioorg Med Chem Lett. 2010 Jun 15;20(12):3788-92. DM74IWX RU https://pubmed.ncbi.nlm.nih.gov/20471260 DM1GCV3 DI DM1GCV3 DM1GCV3 DN (R)-2-(4-Benzylphenoxymethyl)pyrrolidine DM1GCV3 MI TTXZEAJ DM1GCV3 MN Leukotriene A-4 hydrolase (LTA4H) DM1GCV3 MT DTT DM1GCV3 MA Inhibitor DM1GCV3 RN Discovery of 4-[(2S)-2-{[4-(4-chlorophenoxy)phenoxy]methyl}-1-pyrrolidinyl]butanoic acid (DG-051) as a novel leukotriene A4 hydrolase inhibitor of ... J Med Chem. 2010 Jan 28;53(2):573-85. DM1GCV3 RU https://pubmed.ncbi.nlm.nih.gov/19950900 DMR8E0G DI DMR8E0G DMR8E0G DN (R)-2-(4-Isobutyl-phenyl)-N-methoxy-propionamide DMR8E0G MI TTMWT8Z DMR8E0G MN C-X-C chemokine receptor type 1 (CXCR1) DMR8E0G MT DTT DMR8E0G MA Inhibitor DMR8E0G RN 2-Arylpropionic CXC chemokine receptor 1 (CXCR1) ligands as novel noncompetitive CXCL8 inhibitors. J Med Chem. 2005 Jun 30;48(13):4312-31. DMR8E0G RU https://pubmed.ncbi.nlm.nih.gov/15974585 DMR8E0G DI DMR8E0G DMR8E0G DN (R)-2-(4-Isobutyl-phenyl)-N-methoxy-propionamide DMR8E0G MI TT30C9G DMR8E0G MN C-X-C chemokine receptor type 2 (CXCR2) DMR8E0G MT DTT DMR8E0G MA Inhibitor DMR8E0G RN 2-Arylpropionic CXC chemokine receptor 1 (CXCR1) ligands as novel noncompetitive CXCL8 inhibitors. J Med Chem. 2005 Jun 30;48(13):4312-31. DMR8E0G RU https://pubmed.ncbi.nlm.nih.gov/15974585 DMAD4JY DI DMAD4JY DMAD4JY DN (R)-2-(4-Isobutyl-phenyl)-N-phenyl-propionamide DMAD4JY MI TT8NGED DMAD4JY MN Prostaglandin G/H synthase 1 (COX-1) DMAD4JY MT DTT DMAD4JY MA Inhibitor DMAD4JY RN 2-Arylpropionic CXC chemokine receptor 1 (CXCR1) ligands as novel noncompetitive CXCL8 inhibitors. J Med Chem. 2005 Jun 30;48(13):4312-31. DMAD4JY RU https://pubmed.ncbi.nlm.nih.gov/15974585 DMAD4JY DI DMAD4JY DMAD4JY DN (R)-2-(4-Isobutyl-phenyl)-N-phenyl-propionamide DMAD4JY MI TTVKILB DMAD4JY MN Prostaglandin G/H synthase 2 (COX-2) DMAD4JY MT DTT DMAD4JY MA Inhibitor DMAD4JY RN 2-Arylpropionic CXC chemokine receptor 1 (CXCR1) ligands as novel noncompetitive CXCL8 inhibitors. J Med Chem. 2005 Jun 30;48(13):4312-31. DMAD4JY RU https://pubmed.ncbi.nlm.nih.gov/15974585 DMBQ0PR DI DMBQ0PR DMBQ0PR DN (R)-2-(4-Isobutyl-phenyl)-propionamide DMBQ0PR MI TTMWT8Z DMBQ0PR MN C-X-C chemokine receptor type 1 (CXCR1) DMBQ0PR MT DTT DMBQ0PR MA Inhibitor DMBQ0PR RN 2-Arylpropionic CXC chemokine receptor 1 (CXCR1) ligands as novel noncompetitive CXCL8 inhibitors. J Med Chem. 2005 Jun 30;48(13):4312-31. DMBQ0PR RU https://pubmed.ncbi.nlm.nih.gov/15974585 DMBQ0PR DI DMBQ0PR DMBQ0PR DN (R)-2-(4-Isobutyl-phenyl)-propionamide DMBQ0PR MI TT30C9G DMBQ0PR MN C-X-C chemokine receptor type 2 (CXCR2) DMBQ0PR MT DTT DMBQ0PR MA Inhibitor DMBQ0PR RN 2-Arylpropionic CXC chemokine receptor 1 (CXCR1) ligands as novel noncompetitive CXCL8 inhibitors. J Med Chem. 2005 Jun 30;48(13):4312-31. DMBQ0PR RU https://pubmed.ncbi.nlm.nih.gov/15974585 DMJVQN8 DI DMJVQN8 DMJVQN8 DN (R)-2-(Benzylamino-methyl)-chroman-7-ol DMJVQN8 MI TT4C8EA DMJVQN8 MN Dopamine D3 receptor (D3R) DMJVQN8 MT DTT DMJVQN8 MA Inhibitor DMJVQN8 RN Molecular modeling of the three-dimensional structure of dopamine 3 (D3) subtype receptor: discovery of novel and potent D3 ligands through a hybri... J Med Chem. 2003 Oct 9;46(21):4377-92. DMJVQN8 RU https://pubmed.ncbi.nlm.nih.gov/14521403 DM16JFS DI DM16JFS DM16JFS DN (R)-2-(biphenyl-4-sulfonylamino)-propionic acid DM16JFS MI TTYG6BU DM16JFS MN Aggrecanase-1 (ADAMTS4) DM16JFS MT DTT DM16JFS MA Inhibitor DM16JFS RN Synthesis and biological evaluation of biphenylsulfonamide carboxylate aggrecanase-1 inhibitors. Bioorg Med Chem Lett. 2006 Jan 15;16(2):311-6. DM16JFS RU https://pubmed.ncbi.nlm.nih.gov/16275085 DM70ZIF DI DM70ZIF DM70ZIF DN (R)-2,11-Diaminoaporphine DM70ZIF MI TTSQIFT DM70ZIF MN 5-HT 1A receptor (HTR1A) DM70ZIF MT DTT DM70ZIF MA Inhibitor DM70ZIF RN Synthesis and pharmacological investigation of novel 2-aminothiazole-privileged aporphines. Bioorg Med Chem. 2008 Jul 15;16(14):6675-81. DM70ZIF RU https://pubmed.ncbi.nlm.nih.gov/18562201 DM70ZIF DI DM70ZIF DM70ZIF DN (R)-2,11-Diaminoaporphine DM70ZIF MI TTZFYLI DM70ZIF MN Dopamine D1 receptor (D1R) DM70ZIF MT DTT DM70ZIF MA Inhibitor DM70ZIF RN Synthesis and pharmacological investigation of novel 2-aminothiazole-privileged aporphines. Bioorg Med Chem. 2008 Jul 15;16(14):6675-81. DM70ZIF RU https://pubmed.ncbi.nlm.nih.gov/18562201 DMRO9C7 DI DMRO9C7 DMRO9C7 DN (R)-2,6-Bis-hydroxymethyl-piperidine-3,4,5-triol DMRO9C7 MI TTLPC70 DMRO9C7 MN Lysosomal alpha-glucosidase (GAA) DMRO9C7 MT DTT DMRO9C7 MA Inhibitor DMRO9C7 RN Homonojirimycin isomers and N-alkylated homonojirimycins: structural and conformational basis of inhibition of glycosidases. J Med Chem. 1998 Jul 2;41(14):2565-71. DMRO9C7 RU https://pubmed.ncbi.nlm.nih.gov/9651160 DMZXT34 DI DMZXT34 DMZXT34 DN (R)-2-amino-3-(4-octylphenylamino)propan-1-ol DMZXT34 MI TTCN0M9 DMZXT34 MN Sphingosine kinase 2 (SPHK2) DMZXT34 MT DTT DMZXT34 MA Inhibitor DMZXT34 RN Discovery of novel sphingosine kinase 1 inhibitors. Bioorg Med Chem Lett. 2009 Nov 1;19(21):6119-21. DMZXT34 RU https://pubmed.ncbi.nlm.nih.gov/19800228 DMA1EFL DI DMA1EFL DMA1EFL DN (R)-2-amino-4-hydroxy-N-(4-octylphenyl)butanamide DMA1EFL MI TTCN0M9 DMA1EFL MN Sphingosine kinase 2 (SPHK2) DMA1EFL MT DTT DMA1EFL MA Inhibitor DMA1EFL RN Discovery of novel sphingosine kinase 1 inhibitors. Bioorg Med Chem Lett. 2009 Nov 1;19(21):6119-21. DMA1EFL RU https://pubmed.ncbi.nlm.nih.gov/19800228 DMSY4CK DI DMSY4CK DMSY4CK DN (R)-2-Amino-5-phosphono-pentanoic acid DMSY4CK MI TTLD29N DMSY4CK MN Glutamate receptor ionotropic NMDA 1 (NMDAR1) DMSY4CK MT DTT DMSY4CK MA Inhibitor DMSY4CK RN Synthesis and pharmacology of N1-substituted piperazine-2,3-dicarboxylic acid derivatives acting as NMDA receptor antagonists. J Med Chem. 2005 Apr 7;48(7):2627-37. DMSY4CK RU https://pubmed.ncbi.nlm.nih.gov/15801853 DMSY4CK DI DMSY4CK DMSY4CK DN (R)-2-Amino-5-phosphono-pentanoic acid DMSY4CK MI TTKJEMQ DMSY4CK MN Glutamate receptor ionotropic NMDA 2A (NMDAR2A) DMSY4CK MT DTT DMSY4CK MA Inhibitor DMSY4CK RN Synthesis and pharmacology of N1-substituted piperazine-2,3-dicarboxylic acid derivatives acting as NMDA receptor antagonists. J Med Chem. 2005 Apr 7;48(7):2627-37. DMSY4CK RU https://pubmed.ncbi.nlm.nih.gov/15801853 DMSY4CK DI DMSY4CK DMSY4CK DN (R)-2-Amino-5-phosphono-pentanoic acid DMSY4CK MI TTN9D8E DMSY4CK MN Glutamate receptor ionotropic NMDA 2B (NMDAR2B) DMSY4CK MT DTT DMSY4CK MA Inhibitor DMSY4CK RN Synthesis and pharmacology of N1-substituted piperazine-2,3-dicarboxylic acid derivatives acting as NMDA receptor antagonists. J Med Chem. 2005 Apr 7;48(7):2627-37. DMSY4CK RU https://pubmed.ncbi.nlm.nih.gov/15801853 DM4XEHR DI DM4XEHR DM4XEHR DN (R)-2-Amino-7-phosphono-heptanoic acid DM4XEHR MI TTLD29N DM4XEHR MN Glutamate receptor ionotropic NMDA 1 (NMDAR1) DM4XEHR MT DTT DM4XEHR MA Inhibitor DM4XEHR RN Synthesis and pharmacology of N1-substituted piperazine-2,3-dicarboxylic acid derivatives acting as NMDA receptor antagonists. J Med Chem. 2005 Apr 7;48(7):2627-37. DM4XEHR RU https://pubmed.ncbi.nlm.nih.gov/15801853 DM4XEHR DI DM4XEHR DM4XEHR DN (R)-2-Amino-7-phosphono-heptanoic acid DM4XEHR MI TTKJEMQ DM4XEHR MN Glutamate receptor ionotropic NMDA 2A (NMDAR2A) DM4XEHR MT DTT DM4XEHR MA Inhibitor DM4XEHR RN Synthesis and pharmacology of N1-substituted piperazine-2,3-dicarboxylic acid derivatives acting as NMDA receptor antagonists. J Med Chem. 2005 Apr 7;48(7):2627-37. DM4XEHR RU https://pubmed.ncbi.nlm.nih.gov/15801853 DM4XEHR DI DM4XEHR DM4XEHR DN (R)-2-Amino-7-phosphono-heptanoic acid DM4XEHR MI TTN9D8E DM4XEHR MN Glutamate receptor ionotropic NMDA 2B (NMDAR2B) DM4XEHR MT DTT DM4XEHR MA Inhibitor DM4XEHR RN Synthesis and pharmacology of N1-substituted piperazine-2,3-dicarboxylic acid derivatives acting as NMDA receptor antagonists. J Med Chem. 2005 Apr 7;48(7):2627-37. DM4XEHR RU https://pubmed.ncbi.nlm.nih.gov/15801853 DMT8HP1 DI DMT8HP1 DMT8HP1 DN (R)-2-methyl-1-(2-m-tolyl-ethyl)-pyrrolidine DMT8HP1 MI TT9JNIC DMT8HP1 MN Histamine H3 receptor (H3R) DMT8HP1 MT DTT DMT8HP1 MA Inhibitor DMT8HP1 RN In vitro SAR of pyrrolidine-containing histamine H3 receptor antagonists: trends across multiple chemical series. Bioorg Med Chem Lett. 2008 Jan 1;18(1):355-9. DMT8HP1 RU https://pubmed.ncbi.nlm.nih.gov/18077160 DMA1FUH DI DMA1FUH DMA1FUH DN (R)-2-methyl-1-(2-p-tolyl-ethyl)-pyrrolidine DMA1FUH MI TT9JNIC DMA1FUH MN Histamine H3 receptor (H3R) DMA1FUH MT DTT DMA1FUH MA Inhibitor DMA1FUH RN In vitro SAR of pyrrolidine-containing histamine H3 receptor antagonists: trends across multiple chemical series. Bioorg Med Chem Lett. 2008 Jan 1;18(1):355-9. DMA1FUH RU https://pubmed.ncbi.nlm.nih.gov/18077160 DMRZDM0 DI DMRZDM0 DMRZDM0 DN (R)-3-(1'-Adamantanecarbonyl)amino-caprolactam DMRZDM0 MI TTFZYTO DMRZDM0 MN C-C chemokine receptor type 2 (CCR2) DMRZDM0 MT DTT DMRZDM0 MA Inhibitor DMRZDM0 RN Highly potent, orally available anti-inflammatory broad-spectrum chemokine inhibitors. J Med Chem. 2009 Jun 11;52(11):3591-5. DMRZDM0 RU https://pubmed.ncbi.nlm.nih.gov/19425597 DMCSHI3 DI DMCSHI3 DMCSHI3 DN (R)-3-(1H-imidazol-4-yl)propyl sec-butylcarbamate DMCSHI3 MI TT9JNIC DMCSHI3 MN Histamine H3 receptor (H3R) DMCSHI3 MT DTT DMCSHI3 MA Inhibitor DMCSHI3 RN Histamine H3 and H4 receptor affinity of branched 3-(1H-imidazol-4-yl)propyl N-alkylcarbamates. Bioorg Med Chem Lett. 2009 Dec 1;19(23):6682-5. DMCSHI3 RU https://pubmed.ncbi.nlm.nih.gov/19846299 DMCSHI3 DI DMCSHI3 DMCSHI3 DN (R)-3-(1H-imidazol-4-yl)propyl sec-butylcarbamate DMCSHI3 MI TTXJ178 DMCSHI3 MN Histamine H4 receptor (H4R) DMCSHI3 MT DTT DMCSHI3 MA Inhibitor DMCSHI3 RN Histamine H3 and H4 receptor affinity of branched 3-(1H-imidazol-4-yl)propyl N-alkylcarbamates. Bioorg Med Chem Lett. 2009 Dec 1;19(23):6682-5. DMCSHI3 RU https://pubmed.ncbi.nlm.nih.gov/19846299 DMUFP7W DI DMUFP7W DMUFP7W DN (R)-3-(2-(2-methylpyrrolidin-1-yl)ethyl)pyridine DMUFP7W MI TT9JNIC DMUFP7W MN Histamine H3 receptor (H3R) DMUFP7W MT DTT DMUFP7W MA Inhibitor DMUFP7W RN In vitro SAR of pyrrolidine-containing histamine H3 receptor antagonists: trends across multiple chemical series. Bioorg Med Chem Lett. 2008 Jan 1;18(1):355-9. DMUFP7W RU https://pubmed.ncbi.nlm.nih.gov/18077160 DM5TH2W DI DM5TH2W DM5TH2W DN (R)-3-(2-naphthamido)-4-m-tolylbutanoic acid DM5TH2W MI TTJNTSI DM5TH2W MN Rotamase Pin1 (PIN1) DM5TH2W MT DTT DM5TH2W MA Inhibitor DM5TH2W RN Structure-based design of novel human Pin1 inhibitors (II). Bioorg Med Chem Lett. 2010 Apr 1;20(7):2210-4. DM5TH2W RU https://pubmed.ncbi.nlm.nih.gov/20207139 DMQ2KF8 DI DMQ2KF8 DMQ2KF8 DN (R)-3-(4-Isobutyl-phenyl)-butan-2-one DMQ2KF8 MI TTMWT8Z DMQ2KF8 MN C-X-C chemokine receptor type 1 (CXCR1) DMQ2KF8 MT DTT DMQ2KF8 MA Inhibitor DMQ2KF8 RN 2-Arylpropionic CXC chemokine receptor 1 (CXCR1) ligands as novel noncompetitive CXCL8 inhibitors. J Med Chem. 2005 Jun 30;48(13):4312-31. DMQ2KF8 RU https://pubmed.ncbi.nlm.nih.gov/15974585 DMQ2KF8 DI DMQ2KF8 DMQ2KF8 DN (R)-3-(4-Isobutyl-phenyl)-butan-2-one DMQ2KF8 MI TT30C9G DMQ2KF8 MN C-X-C chemokine receptor type 2 (CXCR2) DMQ2KF8 MT DTT DMQ2KF8 MA Inhibitor DMQ2KF8 RN 2-Arylpropionic CXC chemokine receptor 1 (CXCR1) ligands as novel noncompetitive CXCL8 inhibitors. J Med Chem. 2005 Jun 30;48(13):4312-31. DMQ2KF8 RU https://pubmed.ncbi.nlm.nih.gov/15974585 DMC73DY DI DMC73DY DMC73DY DN (R)-3-(4-propylmorpholin-2-yl)phenol DMC73DY MI TTJQOD7 DMC73DY MN 5-HT 2A receptor (HTR2A) DMC73DY MT DTT DMC73DY MA Inhibitor DMC73DY RN Design and synthesis of a functionally selective D3 agonist and its in vivo delivery via the intranasal route. Bioorg Med Chem Lett. 2007 Dec 15;17(24):6691-6. DMC73DY RU https://pubmed.ncbi.nlm.nih.gov/17976986 DM2DVNT DI DM2DVNT DM2DVNT DN (R)-3-(aminomethyl)-4-(furan-2-yl)butanoic acid DM2DVNT MI TTFK1JQ DM2DVNT MN Voltage-gated calcium channel alpha-2/delta-1 (CACNA2D1) DM2DVNT MT DTT DM2DVNT MA Inhibitor DM2DVNT RN Heteroaromatic side-chain analogs of pregabalin. Bioorg Med Chem Lett. 2006 May 1;16(9):2329-32. DM2DVNT RU https://pubmed.ncbi.nlm.nih.gov/16099652 DM94B12 DI DM94B12 DM94B12 DN (R)-3-(naphthalen-2-ylmethoxy)pyrrolidine DM94B12 MI TTVBI8W DM94B12 MN Dopamine transporter (DAT) DM94B12 MT DTT DM94B12 MA Inhibitor DM94B12 RN Design and optimization of selective serotonin re-uptake inhibitors with high synthetic accessibility. Part 1. Bioorg Med Chem Lett. 2009 Apr 15;19(8):2329-32. DM94B12 RU https://pubmed.ncbi.nlm.nih.gov/19282174 DM94B12 DI DM94B12 DM94B12 DN (R)-3-(naphthalen-2-ylmethoxy)pyrrolidine DM94B12 MI TTAWNKZ DM94B12 MN Norepinephrine transporter (NET) DM94B12 MT DTT DM94B12 MA Inhibitor DM94B12 RN Design and optimization of selective serotonin re-uptake inhibitors with high synthetic accessibility. Part 1. Bioorg Med Chem Lett. 2009 Apr 15;19(8):2329-32. DM94B12 RU https://pubmed.ncbi.nlm.nih.gov/19282174 DM94B12 DI DM94B12 DM94B12 DN (R)-3-(naphthalen-2-ylmethoxy)pyrrolidine DM94B12 MI TT3ROYC DM94B12 MN Serotonin transporter (SERT) DM94B12 MT DTT DM94B12 MA Inhibitor DM94B12 RN Design and optimization of selective serotonin re-uptake inhibitors with high synthetic accessibility. Part 1. Bioorg Med Chem Lett. 2009 Apr 15;19(8):2329-32. DM94B12 RU https://pubmed.ncbi.nlm.nih.gov/19282174 DM94B12 DI DM94B12 DM94B12 DN (R)-3-(naphthalen-2-ylmethoxy)pyrrolidine DM94B12 MI TTQ6VDM DM94B12 MN Voltage-gated potassium channel Kv11.1 (KCNH2) DM94B12 MT DTT DM94B12 MA Inhibitor DM94B12 RN Design and optimization of selective serotonin re-uptake inhibitors with high synthetic accessibility. Part 1. Bioorg Med Chem Lett. 2009 Apr 15;19(8):2329-32. DM94B12 RU https://pubmed.ncbi.nlm.nih.gov/19282174 DM98L2X DI DM98L2X DM98L2X DN (R)-3-Methyl-1,2,3,4-tetrahydro-isoquinoline DM98L2X MI TTWG9A4 DM98L2X MN Adrenergic receptor alpha-2A (ADRA2A) DM98L2X MT DTT DM98L2X MA Inhibitor DM98L2X RN Effect of ring size or an additional heteroatom on the potency and selectivity of bicyclic benzylamine-type inhibitors of phenylethanolamine N-meth... J Med Chem. 1996 Aug 30;39(18):3539-46. DM98L2X RU https://pubmed.ncbi.nlm.nih.gov/8784452 DM98L2X DI DM98L2X DM98L2X DN (R)-3-Methyl-1,2,3,4-tetrahydro-isoquinoline DM98L2X MI TTWM4TY DM98L2X MN Adrenergic receptor alpha-2B (ADRA2B) DM98L2X MT DTT DM98L2X MA Inhibitor DM98L2X RN Effect of ring size or an additional heteroatom on the potency and selectivity of bicyclic benzylamine-type inhibitors of phenylethanolamine N-meth... J Med Chem. 1996 Aug 30;39(18):3539-46. DM98L2X RU https://pubmed.ncbi.nlm.nih.gov/8784452 DM98L2X DI DM98L2X DM98L2X DN (R)-3-Methyl-1,2,3,4-tetrahydro-isoquinoline DM98L2X MI TT2NUT5 DM98L2X MN Adrenergic receptor alpha-2C (ADRA2C) DM98L2X MT DTT DM98L2X MA Inhibitor DM98L2X RN Effect of ring size or an additional heteroatom on the potency and selectivity of bicyclic benzylamine-type inhibitors of phenylethanolamine N-meth... J Med Chem. 1996 Aug 30;39(18):3539-46. DM98L2X RU https://pubmed.ncbi.nlm.nih.gov/8784452 DMPEV2W DI DMPEV2W DMPEV2W DN (R)-3-Prop-2-ynylamino-indan-5-ol DMPEV2W MI TTGP7BY DMPEV2W MN Monoamine oxidase type B (MAO-B) DMPEV2W MT DTT DMPEV2W MA Inhibitor DMPEV2W RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DMPEV2W RU https://pubmed.ncbi.nlm.nih.gov/10592235 DM1Y9MZ DI DM1Y9MZ DM1Y9MZ DN (R)-3-Propyl-[1,4]thiazepan-(5E)-ylideneamine DM1Y9MZ MI TTZUFI5 DM1Y9MZ MN Nitric-oxide synthase brain (NOS1) DM1Y9MZ MT DTT DM1Y9MZ MA Inhibitor DM1Y9MZ RN Synthesis of analogs of (1,4)-3- and 5-imino oxazepane, thiazepane, and diazepane as inhibitors of nitric oxide synthases. Bioorg Med Chem Lett. 2004 Dec 6;14(23):5907-11. DM1Y9MZ RU https://pubmed.ncbi.nlm.nih.gov/15501067 DM1Y9MZ DI DM1Y9MZ DM1Y9MZ DN (R)-3-Propyl-[1,4]thiazepan-(5E)-ylideneamine DM1Y9MZ MI TTF10I9 DM1Y9MZ MN Nitric-oxide synthase inducible (NOS2) DM1Y9MZ MT DTT DM1Y9MZ MA Inhibitor DM1Y9MZ RN Synthesis of analogs of (1,4)-3- and 5-imino oxazepane, thiazepane, and diazepane as inhibitors of nitric oxide synthases. Bioorg Med Chem Lett. 2004 Dec 6;14(23):5907-11. DM1Y9MZ RU https://pubmed.ncbi.nlm.nih.gov/15501067 DM5CL8B DI DM5CL8B DM5CL8B DN (R)-4-(2-(2-methylpyrrolidin-1-yl)ethyl)pyridine DM5CL8B MI TT9JNIC DM5CL8B MN Histamine H3 receptor (H3R) DM5CL8B MT DTT DM5CL8B MA Inhibitor DM5CL8B RN In vitro SAR of pyrrolidine-containing histamine H3 receptor antagonists: trends across multiple chemical series. Bioorg Med Chem Lett. 2008 Jan 1;18(1):355-9. DM5CL8B RU https://pubmed.ncbi.nlm.nih.gov/18077160 DMRVOLN DI DMRVOLN DMRVOLN DN (R)-4-[2-[3-(4-methoxy-benzoylamino)-benzyl]-piperidin-1-ylmethyl]piperidine-1-carboxylic acid amide (Ro-320-6206) DMRVOLN MI TTYEG6Q DMRVOLN MN Muscarinic acetylcholine receptor M2 (CHRM2) DMRVOLN MT DTT DMRVOLN MA Antagonist DMRVOLN RN Signal transduction underlying carbachol-induced contraction of human urinary bladder. J Pharmacol Exp Ther. 2004 Jun;309(3):1148-53. DMRVOLN RU https://pubmed.ncbi.nlm.nih.gov/14769832 DM3F56O DI DM3F56O DM3F56O DN (R)-4-amino-2-methylbutanoic acid DM3F56O MI TTNJYV2 DM3F56O MN Gamma-aminobutyric acid receptor (GAR) DM3F56O MT DTT DM3F56O MA Inhibitor DM3F56O RN Enantioselective actions of 4-amino-3-hydroxybutanoic acid and (3-amino-2-hydroxypropyl)methylphosphinic acid at recombinant GABA(C) receptors. Bioorg Med Chem Lett. 2008 Jan 1;18(1):402-4. DM3F56O RU https://pubmed.ncbi.nlm.nih.gov/17981464 DMW87OE DI DMW87OE DMW87OE DN (R)-5-Amino-3-(4-chloro-phenyl)-pentanoic acid DMW87OE MI TTDCVZW DMW87OE MN Gamma-aminobutyric acid B receptor (GABBR) DMW87OE MT DTT DMW87OE MA Inhibitor DMW87OE RN Synthesis and pharmacology of the baclofen homologues 5-amino-4-(4-chlorophenyl)pentanoic acid and the R- and S-enantiomers of 5-amino-3-(4-chlorop... J Med Chem. 1999 Jun 3;42(11):2053-9. DMW87OE RU https://pubmed.ncbi.nlm.nih.gov/10354414 DMOESL1 DI DMOESL1 DMOESL1 DN (R)-5-diphosphomevalonate DMOESL1 MI DE7G63U DMOESL1 MN Mevalonate pyrophosphate decarboxylase (MPD) DMOESL1 MT DME DMOESL1 MA Metabolism DMOESL1 RN The Putative mevalonate diphosphate decarboxylase from Picrophilus torridus is in reality a mevalonate-3-kinase with high potential for bioproduction of isobutene. Appl Environ Microbiol. 2015 Apr;81(7):2625-34. DMOESL1 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=25636853 DMOESL1 DI DMOESL1 DMOESL1 DN (R)-5-diphosphomevalonate DMOESL1 MI TTXMI0C DMOESL1 MN Phosphomevalonate kinase (PMVK) DMOESL1 MT DTT DMOESL1 MA Inhibitor DMOESL1 RN Functional evaluation of conserved basic residues in human phosphomevalonate kinase. Biochemistry. 2007 Oct 23;46(42):11780-8. DMOESL1 RU https://pubmed.ncbi.nlm.nih.gov/17902708 DM3LQFK DI DM3LQFK DM3LQFK DN (R)-6-(2-(2-methylpyrrolidin-1-yl)ethyl)quinoline DM3LQFK MI TT9JNIC DM3LQFK MN Histamine H3 receptor (H3R) DM3LQFK MT DTT DM3LQFK MA Inhibitor DM3LQFK RN In vitro studies on a class of quinoline containing histamine H3 antagonists. Bioorg Med Chem Lett. 2010 Jun 1;20(11):3295-300. DM3LQFK RU https://pubmed.ncbi.nlm.nih.gov/20457525 DM3LQFK DI DM3LQFK DM3LQFK DN (R)-6-(2-(2-methylpyrrolidin-1-yl)ethyl)quinoline DM3LQFK MI TTQ6VDM DM3LQFK MN Voltage-gated potassium channel Kv11.1 (KCNH2) DM3LQFK MT DTT DM3LQFK MA Inhibitor DM3LQFK RN In vitro studies on a class of quinoline containing histamine H3 antagonists. Bioorg Med Chem Lett. 2010 Jun 1;20(11):3295-300. DM3LQFK RU https://pubmed.ncbi.nlm.nih.gov/20457525 DM134UV DI DM134UV DM134UV DN (R)-6-(pyrrolidin-3-ylmethoxy)-2-naphthonitrile DM134UV MI TTAWNKZ DM134UV MN Norepinephrine transporter (NET) DM134UV MT DTT DM134UV MA Inhibitor DM134UV RN Design and optimization of selective serotonin re-uptake inhibitors with high synthetic accessibility. Part 1. Bioorg Med Chem Lett. 2009 Apr 15;19(8):2329-32. DM134UV RU https://pubmed.ncbi.nlm.nih.gov/19282174 DM134UV DI DM134UV DM134UV DN (R)-6-(pyrrolidin-3-ylmethoxy)-2-naphthonitrile DM134UV MI TT3ROYC DM134UV MN Serotonin transporter (SERT) DM134UV MT DTT DM134UV MA Inhibitor DM134UV RN Design and optimization of selective serotonin re-uptake inhibitors with high synthetic accessibility. Part 1. Bioorg Med Chem Lett. 2009 Apr 15;19(8):2329-32. DM134UV RU https://pubmed.ncbi.nlm.nih.gov/19282174 DMCY76E DI DMCY76E DMCY76E DN (R)-8-phenyl-N,N-dipropylchroman-3-amine DMCY76E MI TTO9X1H DMCY76E MN 5-HT 7 receptor (HTR7) DMCY76E MT DTT DMCY76E MA Inhibitor DMCY76E RN SAR studies on new bis-aryls 5-HT7 ligands: Synthesis and molecular modeling. Bioorg Med Chem. 2010 Mar 1;18(5):1958-67. DMCY76E RU https://pubmed.ncbi.nlm.nih.gov/20138771 DMKAW4P DI DMKAW4P DMKAW4P DN (R)-alpha-methylhistamine DMKAW4P MI TT9JNIC DMKAW4P MN Histamine H3 receptor (H3R) DMKAW4P MT DTT DMKAW4P MA Agonist DMKAW4P RN The histamine H3 receptor: from gene cloning to H3 receptor drugs. Nat Rev Drug Discov. 2005 Feb;4(2):107-20. DMKAW4P RU https://pubmed.ncbi.nlm.nih.gov/15665857 DMKAW4P DI DMKAW4P DMKAW4P DN (R)-alpha-methylhistamine DMKAW4P MI TTXJ178 DMKAW4P MN Histamine H4 receptor (H4R) DMKAW4P MT DTT DMKAW4P MA Agonist DMKAW4P RN Cloning and pharmacological characterization of a fourth histamine receptor (H(4)) expressed in bone marrow. Mol Pharmacol. 2001 Mar;59(3):420-6. DMKAW4P RU https://pubmed.ncbi.nlm.nih.gov/11179434 DMECK7H DI DMECK7H DMECK7H DN (R)-DULOXETINE DMECK7H MI TTVBI8W DMECK7H MN Dopamine transporter (DAT) DMECK7H MT DTT DMECK7H MA Inhibitor DMECK7H RN 1-Naphthyl and 4-indolyl arylalkylamines as selective monoamine reuptake inhibitors. Bioorg Med Chem Lett. 2009 Jan 1;19(1):58-61. DMECK7H RU https://pubmed.ncbi.nlm.nih.gov/19038547 DMECK7H DI DMECK7H DMECK7H DN (R)-DULOXETINE DMECK7H MI TTAWNKZ DMECK7H MN Norepinephrine transporter (NET) DMECK7H MT DTT DMECK7H MA Inhibitor DMECK7H RN Inhibition of serotonin and norepinephrine reuptake and inhibition of phosphodiesterase by multi-target inhibitors as potential agents for depression. Bioorg Med Chem. 2009 Oct 1;17(19):6890-7. DMECK7H RU https://pubmed.ncbi.nlm.nih.gov/19740668 DMECK7H DI DMECK7H DMECK7H DN (R)-DULOXETINE DMECK7H MI TT3ROYC DMECK7H MN Serotonin transporter (SERT) DMECK7H MT DTT DMECK7H MA Inhibitor DMECK7H RN 1-Naphthyl and 4-indolyl arylalkylamines as selective monoamine reuptake inhibitors. Bioorg Med Chem Lett. 2009 Jan 1;19(1):58-61. DMECK7H RU https://pubmed.ncbi.nlm.nih.gov/19038547 DM297MU DI DM297MU DM297MU DN (R)-EF-1520 DM297MU MI TTPRKM0 DM297MU MN GABA transporter GAT-1 (SLC6A1) DM297MU MT DTT DM297MU MA Inhibitor DM297MU RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 929). DM297MU RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=929 DM297MU DI DM297MU DM297MU DN (R)-EF-1520 DM297MU MI TTQBMPI DM297MU MN Na(+)/Cl(-) betaine/GABA transporter (SLC6A12) DM297MU MT DTT DM297MU MA Inhibitor DM297MU RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 932). DM297MU RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=932 DM2KBOU DI DM2KBOU DM2KBOU DN (R)-flurocarazolol DM2KBOU MI TTSQIFT DM2KBOU MN 5-HT 1A receptor (HTR1A) DM2KBOU MT DTT DM2KBOU MA Antagonist DM2KBOU RN The in vitro pharmacology of the beta-adrenergic receptor pet ligand (s)-fluorocarazolol reveals high affinity for cloned beta-adrenergic receptors and moderate affinity for the human 5-HT1A receptor. Psychopharmacology (Berl). 2001 Aug;157(1):111-4. DM2KBOU RU https://pubmed.ncbi.nlm.nih.gov/11512051 DM2KBOU DI DM2KBOU DM2KBOU DN (R)-flurocarazolol DM2KBOU MI TTK8CXU DM2KBOU MN 5-HT 1B receptor (HTR1B) DM2KBOU MT DTT DM2KBOU MA Antagonist DM2KBOU RN The in vitro pharmacology of the beta-adrenergic receptor pet ligand (s)-fluorocarazolol reveals high affinity for cloned beta-adrenergic receptors and moderate affinity for the human 5-HT1A receptor. Psychopharmacology (Berl). 2001 Aug;157(1):111-4. DM2KBOU RU https://pubmed.ncbi.nlm.nih.gov/11512051 DMKFPMC DI DMKFPMC DMKFPMC DN (R)-Indan-1-yl-methyl-prop-2-ynyl-amine DMKFPMC MI TT3WG5C DMKFPMC MN Monoamine oxidase type A (MAO-A) DMKFPMC MT DTT DMKFPMC MA Inhibitor DMKFPMC RN Novel dual inhibitors of AChE and MAO derived from hydroxy aminoindan and phenethylamine as potential treatment for Alzheimer's disease. J Med Chem. 2002 Nov 21;45(24):5260-79. DMKFPMC RU https://pubmed.ncbi.nlm.nih.gov/12431053 DMKFPMC DI DMKFPMC DMKFPMC DN (R)-Indan-1-yl-methyl-prop-2-ynyl-amine DMKFPMC MI TTGP7BY DMKFPMC MN Monoamine oxidase type B (MAO-B) DMKFPMC MT DTT DMKFPMC MA Inhibitor DMKFPMC RN Docking studies on monoamine oxidase-B inhibitors: estimation of inhibition constants (K(i)) of a series of experimentally tested compounds. Bioorg Med Chem Lett. 2005 Oct 15;15(20):4438-46. DMKFPMC RU https://pubmed.ncbi.nlm.nih.gov/16137882 DMEXLUR DI DMEXLUR DMEXLUR DN (R)-Mevalonate DMEXLUR MI TTPADOQ DMEXLUR MN HMG-CoA reductase (HMGCR) DMEXLUR MT DTT DMEXLUR MA Inhibitor DMEXLUR RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMEXLUR RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMEXLUR DI DMEXLUR DMEXLUR DN (R)-Mevalonate DMEXLUR MI DEAO92K DMEXLUR MN Mevalonate kinase (MVK) DMEXLUR MT DME DMEXLUR MA Metabolism DMEXLUR RN Biochemical and structural basis for feedback inhibition of mevalonate kinase and isoprenoid metabolism. Biochemistry. 2008 Mar 25;47(12):3715-24. DMEXLUR RU https://www.ncbi.nlm.nih.gov/pubmed/?term=18302342 DMPKWIN DI DMPKWIN DMPKWIN DN (R)-N2-{4-[(3-chlorobenzyl)oxy]benzyl}alaninamide DMPKWIN MI TTGP7BY DMPKWIN MN Monoamine oxidase type B (MAO-B) DMPKWIN MT DTT DMPKWIN MA Inhibitor DMPKWIN RN Solid-phase synthesis and insights into structure-activity relationships of safinamide analogues as potent and selective inhibitors of type B monoa... J Med Chem. 2007 Oct 4;50(20):4909-16. DMPKWIN RU https://pubmed.ncbi.nlm.nih.gov/17824599 DMEVM6G DI DMEVM6G DMEVM6G DN (R)-N2-{4-[(3-chlorobenzyl)oxy]benzyl}serinamide DMEVM6G MI TTGP7BY DMEVM6G MN Monoamine oxidase type B (MAO-B) DMEVM6G MT DTT DMEVM6G MA Inhibitor DMEVM6G RN Solid-phase synthesis and insights into structure-activity relationships of safinamide analogues as potent and selective inhibitors of type B monoa... J Med Chem. 2007 Oct 4;50(20):4909-16. DMEVM6G RU https://pubmed.ncbi.nlm.nih.gov/17824599 DMU49JN DI DMU49JN DMU49JN DN (R)-N2-{4-[(3-fluorobenzyl)oxy]benzyl}alaninamide DMU49JN MI TTGP7BY DMU49JN MN Monoamine oxidase type B (MAO-B) DMU49JN MT DTT DMU49JN MA Inhibitor DMU49JN RN Solid-phase synthesis and insights into structure-activity relationships of safinamide analogues as potent and selective inhibitors of type B monoa... J Med Chem. 2007 Oct 4;50(20):4909-16. DMU49JN RU https://pubmed.ncbi.nlm.nih.gov/17824599 DMM8TE0 DI DMM8TE0 DMM8TE0 DN (R)-N-benzyl-4-(pyrrolidin-2-ylmethoxy)aniline DMM8TE0 MI TTXZEAJ DMM8TE0 MN Leukotriene A-4 hydrolase (LTA4H) DMM8TE0 MT DTT DMM8TE0 MA Inhibitor DMM8TE0 RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DMM8TE0 RU https://pubmed.ncbi.nlm.nih.gov/10592235 DMWRIQG DI DMWRIQG DMWRIQG DN (R)-N-Hydroxy-2-(4-isobutyl-phenyl)-propionamide DMWRIQG MI TTMWT8Z DMWRIQG MN C-X-C chemokine receptor type 1 (CXCR1) DMWRIQG MT DTT DMWRIQG MA Inhibitor DMWRIQG RN 2-Arylpropionic CXC chemokine receptor 1 (CXCR1) ligands as novel noncompetitive CXCL8 inhibitors. J Med Chem. 2005 Jun 30;48(13):4312-31. DMWRIQG RU https://pubmed.ncbi.nlm.nih.gov/15974585 DMWRIQG DI DMWRIQG DMWRIQG DN (R)-N-Hydroxy-2-(4-isobutyl-phenyl)-propionamide DMWRIQG MI TT30C9G DMWRIQG MN C-X-C chemokine receptor type 2 (CXCR2) DMWRIQG MT DTT DMWRIQG MA Inhibitor DMWRIQG RN 2-Arylpropionic CXC chemokine receptor 1 (CXCR1) ligands as novel noncompetitive CXCL8 inhibitors. J Med Chem. 2005 Jun 30;48(13):4312-31. DMWRIQG RU https://pubmed.ncbi.nlm.nih.gov/15974585 DMWGB40 DI DMWGB40 DMWGB40 DN (R)-nipecotic acid DMWGB40 MI TTPRKM0 DMWGB40 MN GABA transporter GAT-1 (SLC6A1) DMWGB40 MT DTT DMWGB40 MA Inhibitor DMWGB40 RN Novel secoergoline derivatives inhibit both GABA and glutamate uptake in rat brain homogenates: synthesis, in vitro pharmacology, and modeling. J Med Chem. 2004 Nov 4;47(23):5620-9. DMWGB40 RU https://pubmed.ncbi.nlm.nih.gov/15509161 DMWGB40 DI DMWGB40 DMWGB40 DN (R)-nipecotic acid DMWGB40 MI TTV9MQG DMWGB40 MN Gamma-aminobutyric acid uptake (GABAU) DMWGB40 MT DTT DMWGB40 MA Inhibitor DMWGB40 RN GABA uptake inhibitors. Design, molecular pharmacology and therapeutic aspects. Curr Pharm Des. 2000 Aug;6(12):1193-209. DMWGB40 RU https://pubmed.ncbi.nlm.nih.gov/10903390 DMJFH97 DI DMJFH97 DMJFH97 DN (R)-N-isobutyl-N-(pyrrolidin-3-yl)-2-naphthamide DMJFH97 MI TTVBI8W DMJFH97 MN Dopamine transporter (DAT) DMJFH97 MT DTT DMJFH97 MA Inhibitor DMJFH97 RN Bioorg Med Chem Lett. 2009 Oct 15;19(20):5893-7. Epub 2009 Aug 21.Design and optimisation of selective serotonin re-uptake inhibitors with high synthetic accessibility: part 2. DMJFH97 RU https://pubmed.ncbi.nlm.nih.gov/19740658 DMJFH97 DI DMJFH97 DMJFH97 DN (R)-N-isobutyl-N-(pyrrolidin-3-yl)-2-naphthamide DMJFH97 MI TTAWNKZ DMJFH97 MN Norepinephrine transporter (NET) DMJFH97 MT DTT DMJFH97 MA Inhibitor DMJFH97 RN Bioorg Med Chem Lett. 2009 Oct 15;19(20):5893-7. Epub 2009 Aug 21.Design and optimisation of selective serotonin re-uptake inhibitors with high synthetic accessibility: part 2. DMJFH97 RU https://pubmed.ncbi.nlm.nih.gov/19740658 DMJFH97 DI DMJFH97 DMJFH97 DN (R)-N-isobutyl-N-(pyrrolidin-3-yl)-2-naphthamide DMJFH97 MI TT3ROYC DMJFH97 MN Serotonin transporter (SERT) DMJFH97 MT DTT DMJFH97 MA Inhibitor DMJFH97 RN Bioorg Med Chem Lett. 2009 Oct 15;19(20):5893-7. Epub 2009 Aug 21.Design and optimisation of selective serotonin re-uptake inhibitors with high synthetic accessibility: part 2. DMJFH97 RU https://pubmed.ncbi.nlm.nih.gov/19740658 DMJFH97 DI DMJFH97 DMJFH97 DN (R)-N-isobutyl-N-(pyrrolidin-3-yl)-2-naphthamide DMJFH97 MI TTQ6VDM DMJFH97 MN Voltage-gated potassium channel Kv11.1 (KCNH2) DMJFH97 MT DTT DMJFH97 MA Inhibitor DMJFH97 RN Bioorg Med Chem Lett. 2009 Oct 15;19(20):5893-7. Epub 2009 Aug 21.Design and optimisation of selective serotonin re-uptake inhibitors with high synthetic accessibility: part 2. DMJFH97 RU https://pubmed.ncbi.nlm.nih.gov/19740658 DMQIUOB DI DMQIUOB DMQIUOB DN (R)-N-isopropyl-N-(pyrrolidin-3-yl)-2-naphthamide DMQIUOB MI TTAWNKZ DMQIUOB MN Norepinephrine transporter (NET) DMQIUOB MT DTT DMQIUOB MA Inhibitor DMQIUOB RN Bioorg Med Chem Lett. 2009 Oct 15;19(20):5893-7. Epub 2009 Aug 21.Design and optimisation of selective serotonin re-uptake inhibitors with high synthetic accessibility: part 2. DMQIUOB RU https://pubmed.ncbi.nlm.nih.gov/19740658 DMQIUOB DI DMQIUOB DMQIUOB DN (R)-N-isopropyl-N-(pyrrolidin-3-yl)-2-naphthamide DMQIUOB MI TT3ROYC DMQIUOB MN Serotonin transporter (SERT) DMQIUOB MT DTT DMQIUOB MA Inhibitor DMQIUOB RN Bioorg Med Chem Lett. 2009 Oct 15;19(20):5893-7. Epub 2009 Aug 21.Design and optimisation of selective serotonin re-uptake inhibitors with high synthetic accessibility: part 2. DMQIUOB RU https://pubmed.ncbi.nlm.nih.gov/19740658 DMIHR14 DI DMIHR14 DMIHR14 DN (R)-N-oleoyltyrosinol DMIHR14 MI TT7QNVC DMIHR14 MN Glucose-dependent insulinotropic receptor (GPR119) DMIHR14 MT DTT DMIHR14 MA Agonist DMIHR14 RN N-oleoyldopamine enhances glucose homeostasis through the activation of GPR119. Mol Endocrinol. 2010 Jan;24(1):161-70. DMIHR14 RU https://pubmed.ncbi.nlm.nih.gov/19901198 DMS30KU DI DMS30KU DMS30KU DN (R)-Norfluoxetine DMS30KU MI TTVBI8W DMS30KU MN Dopamine transporter (DAT) DMS30KU MT DTT DMS30KU MA Inhibitor DMS30KU RN Stereoselective inhibition of serotonin re-uptake and phosphodiesterase by dual inhibitors as potential agents for depression. Bioorg Med Chem. 2009 Jan 1;17(1):337-43. DMS30KU RU https://pubmed.ncbi.nlm.nih.gov/19014888 DMS30KU DI DMS30KU DMS30KU DN (R)-Norfluoxetine DMS30KU MI TTAWNKZ DMS30KU MN Norepinephrine transporter (NET) DMS30KU MT DTT DMS30KU MA Inhibitor DMS30KU RN Stereoselective inhibition of serotonin re-uptake and phosphodiesterase by dual inhibitors as potential agents for depression. Bioorg Med Chem. 2009 Jan 1;17(1):337-43. DMS30KU RU https://pubmed.ncbi.nlm.nih.gov/19014888 DMS30KU DI DMS30KU DMS30KU DN (R)-Norfluoxetine DMS30KU MI TT3ROYC DMS30KU MN Serotonin transporter (SERT) DMS30KU MT DTT DMS30KU MA Inhibitor DMS30KU RN Stereoselective inhibition of serotonin re-uptake and phosphodiesterase by dual inhibitors as potential agents for depression. Bioorg Med Chem. 2009 Jan 1;17(1):337-43. DMS30KU RU https://pubmed.ncbi.nlm.nih.gov/19014888 DMCYD8Q DI DMCYD8Q DMCYD8Q DN (R)-ONDANSETRON DMCYD8Q MI TTQ6VDM DMCYD8Q MN Voltage-gated potassium channel Kv11.1 (KCNH2) DMCYD8Q MT DTT DMCYD8Q MA Inhibitor DMCYD8Q RN A binary QSAR model for classification of hERG potassium channel blockers. Bioorg Med Chem. 2008 Apr 1;16(7):4107-19. DMCYD8Q RU https://pubmed.ncbi.nlm.nih.gov/18243713 DM03N5V DI DM03N5V DM03N5V DN (R)PK-11195 DM03N5V MI TTPTXIN DM03N5V MN Translocator protein (TSPO) DM03N5V MT DTT DM03N5V MA Inhibitor DM03N5V RN [18F]FMDAA1106 and [18F]FEDAA1106: two positron-emitter labeled ligands for peripheral benzodiazepine receptor (PBR). Bioorg Med Chem Lett. 2003 Jan 20;13(2):201-4. DM03N5V RU https://pubmed.ncbi.nlm.nih.gov/12482423 DM95Z4Q DI DM95Z4Q DM95Z4Q DN (R)-Rolipram DM95Z4Q MI TTV5CGO DM95Z4Q MN Phosphodiesterase 4 (PDE4) DM95Z4Q MT DTT DM95Z4Q MA Inhibitor DM95Z4Q RN PDE4 inhibitors roflumilast and rolipram augment PGE2 inhibition of TGF-{beta}1-stimulated fibroblasts. Am J Physiol Lung Cell Mol Physiol. 2009 Jun;296(6):L959-69. DM95Z4Q RU https://pubmed.ncbi.nlm.nih.gov/19304913 DM95Z4Q DI DM95Z4Q DM95Z4Q DN (R)-Rolipram DM95Z4Q MI TTZ97H5 DM95Z4Q MN Phosphodiesterase 4A (PDE4A) DM95Z4Q MT DTT DM95Z4Q MA Inhibitor DM95Z4Q RN PDE4 inhibitors roflumilast and rolipram augment PGE2 inhibition of TGF-{beta}1-stimulated fibroblasts. Am J Physiol Lung Cell Mol Physiol. 2009 Jun;296(6):L959-69. DM95Z4Q RU https://pubmed.ncbi.nlm.nih.gov/19304913 DM95Z4Q DI DM95Z4Q DM95Z4Q DN (R)-Rolipram DM95Z4Q MI TTVIAT9 DM95Z4Q MN Phosphodiesterase 4B (PDE4B) DM95Z4Q MT DTT DM95Z4Q MA Inhibitor DM95Z4Q RN PDE4 inhibitors roflumilast and rolipram augment PGE2 inhibition of TGF-{beta}1-stimulated fibroblasts. Am J Physiol Lung Cell Mol Physiol. 2009 Jun;296(6):L959-69. DM95Z4Q RU https://pubmed.ncbi.nlm.nih.gov/19304913 DMV1IS8 DI DMV1IS8 DMV1IS8 DN (R)-sirtinol DMV1IS8 MI TTUF2HO DMV1IS8 MN NAD-dependent deacetylase sirtuin-1 (SIRT1) DMV1IS8 MT DTT DMV1IS8 MA Inhibitor DMV1IS8 RN Design, synthesis, and biological evaluation of sirtinol analogues as class III histone/protein deacetylase (Sirtuin) inhibitors. J Med Chem. 2005 Dec 1;48(24):7789-95. DMV1IS8 RU https://pubmed.ncbi.nlm.nih.gov/16302818 DMSFA2D DI DMSFA2D DMSFA2D DN (R)-tacrine(10)-hupyridone DMSFA2D MI TT1RS9F DMSFA2D MN Acetylcholinesterase (AChE) DMSFA2D MT DTT DMSFA2D MA Inhibitor DMSFA2D RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DMSFA2D RU https://pubmed.ncbi.nlm.nih.gov/10592235 DMT6J51 DI DMT6J51 DMT6J51 DN (R)-zacopride DMT6J51 MI TTNXLKE DMT6J51 MN 5-HT 3 receptor (5HT3R) DMT6J51 MT DTT DMT6J51 MA Modulator DMT6J51 RN R-zacopride, a 5-HT3 antagonist/5-HT4 agonist, reduces sleep apneas in rats. Pharmacol Biochem Behav. 2001 May-Jun;69(1-2):283-9. DMT6J51 RU https://www.ncbi.nlm.nih.gov/pubmed/11420096 DMT6J51 DI DMT6J51 DMT6J51 DN (R)-zacopride DMT6J51 MI TT07C3Y DMT6J51 MN 5-HT 4 receptor (HTR4) DMT6J51 MT DTT DMT6J51 MA Modulator DMT6J51 RN R-zacopride, a 5-HT3 antagonist/5-HT4 agonist, reduces sleep apneas in rats. Pharmacol Biochem Behav. 2001 May-Jun;69(1-2):283-9. DMT6J51 RU https://www.ncbi.nlm.nih.gov/pubmed/11420096 DMCW5A9 DI DMCW5A9 DMCW5A9 DN (R,)-2-(2-naphthamido)-5-phenylpent-4-enoic acid DMCW5A9 MI TTJNTSI DMCW5A9 MN Rotamase Pin1 (PIN1) DMCW5A9 MT DTT DMCW5A9 MA Inhibitor DMCW5A9 RN Structure-based design of novel human Pin1 inhibitors (II). Bioorg Med Chem Lett. 2010 Apr 1;20(7):2210-4. DMCW5A9 RU https://pubmed.ncbi.nlm.nih.gov/20207139 DM3FQYS DI DM3FQYS DM3FQYS DN (R,R)-(-)-fenoterol DM3FQYS MI TTR6W5O DM3FQYS MN Adrenergic receptor beta-1 (ADRB1) DM3FQYS MT DTT DM3FQYS MA Inhibitor DM3FQYS RN Comparative molecular field analysis of the binding of the stereoisomers of fenoterol and fenoterol derivatives to the beta2 adrenergic receptor. J Med Chem. 2007 Jun 14;50(12):2903-15. DM3FQYS RU https://pubmed.ncbi.nlm.nih.gov/17506540 DM3FQYS DI DM3FQYS DM3FQYS DN (R,R)-(-)-fenoterol DM3FQYS MI TT2CJVK DM3FQYS MN Adrenergic receptor beta-2 (ADRB2) DM3FQYS MT DTT DM3FQYS MA Inhibitor DM3FQYS RN Comparative molecular field analysis of the binding of the stereoisomers of fenoterol and fenoterol derivatives to the beta2 adrenergic receptor. J Med Chem. 2007 Jun 14;50(12):2903-15. DM3FQYS RU https://pubmed.ncbi.nlm.nih.gov/17506540 DMETQBI DI DMETQBI DMETQBI DN (R,S)-(-)-fenoterol DMETQBI MI TTR6W5O DMETQBI MN Adrenergic receptor beta-1 (ADRB1) DMETQBI MT DTT DMETQBI MA Inhibitor DMETQBI RN Comparative molecular field analysis of the binding of the stereoisomers of fenoterol and fenoterol derivatives to the beta2 adrenergic receptor. J Med Chem. 2007 Jun 14;50(12):2903-15. DMETQBI RU https://pubmed.ncbi.nlm.nih.gov/17506540 DMETQBI DI DMETQBI DMETQBI DN (R,S)-(-)-fenoterol DMETQBI MI TT2CJVK DMETQBI MN Adrenergic receptor beta-2 (ADRB2) DMETQBI MT DTT DMETQBI MA Inhibitor DMETQBI RN Comparative molecular field analysis of the binding of the stereoisomers of fenoterol and fenoterol derivatives to the beta2 adrenergic receptor. J Med Chem. 2007 Jun 14;50(12):2903-15. DMETQBI RU https://pubmed.ncbi.nlm.nih.gov/17506540 DMKZ4C6 DI DMKZ4C6 DMKZ4C6 DN (R,S)-1-(5-bromo-1H-indol-1-yl)propan-2-amine DMKZ4C6 MI TTJQOD7 DMKZ4C6 MN 5-HT 2A receptor (HTR2A) DMKZ4C6 MT DTT DMKZ4C6 MA Inhibitor DMKZ4C6 RN Synthesis and structure-affinity relationships of novel small molecule natural product derivatives capable of discriminating between serotonin 5-HT1A, 5-HT2A, 5-HT2C receptor subtypes. Bioorg Med Chem. 2010 Jul 1;18(13):4783-92. DMKZ4C6 RU https://pubmed.ncbi.nlm.nih.gov/20570529 DMKZ4C6 DI DMKZ4C6 DMKZ4C6 DN (R,S)-1-(5-bromo-1H-indol-1-yl)propan-2-amine DMKZ4C6 MI TTWJBZ5 DMKZ4C6 MN 5-HT 2C receptor (HTR2C) DMKZ4C6 MT DTT DMKZ4C6 MA Inhibitor DMKZ4C6 RN Synthesis and structure-affinity relationships of novel small molecule natural product derivatives capable of discriminating between serotonin 5-HT1A, 5-HT2A, 5-HT2C receptor subtypes. Bioorg Med Chem. 2010 Jul 1;18(13):4783-92. DMKZ4C6 RU https://pubmed.ncbi.nlm.nih.gov/20570529 DMTZDAJ DI DMTZDAJ DMTZDAJ DN (R,S)-1-(5-chloro-1H-indol-1-yl)propan-2-amine DMTZDAJ MI TTJQOD7 DMTZDAJ MN 5-HT 2A receptor (HTR2A) DMTZDAJ MT DTT DMTZDAJ MA Inhibitor DMTZDAJ RN Synthesis and structure-affinity relationships of novel small molecule natural product derivatives capable of discriminating between serotonin 5-HT1A, 5-HT2A, 5-HT2C receptor subtypes. Bioorg Med Chem. 2010 Jul 1;18(13):4783-92. DMTZDAJ RU https://pubmed.ncbi.nlm.nih.gov/20570529 DMTZDAJ DI DMTZDAJ DMTZDAJ DN (R,S)-1-(5-chloro-1H-indol-1-yl)propan-2-amine DMTZDAJ MI TTWJBZ5 DMTZDAJ MN 5-HT 2C receptor (HTR2C) DMTZDAJ MT DTT DMTZDAJ MA Inhibitor DMTZDAJ RN Synthesis and structure-affinity relationships of novel small molecule natural product derivatives capable of discriminating between serotonin 5-HT1A, 5-HT2A, 5-HT2C receptor subtypes. Bioorg Med Chem. 2010 Jul 1;18(13):4783-92. DMTZDAJ RU https://pubmed.ncbi.nlm.nih.gov/20570529 DMAU1M5 DI DMAU1M5 DMAU1M5 DN (R,S)-1-(5-fluoro-1H-indol-1-yl)propan-2-amine DMAU1M5 MI TTJQOD7 DMAU1M5 MN 5-HT 2A receptor (HTR2A) DMAU1M5 MT DTT DMAU1M5 MA Inhibitor DMAU1M5 RN Synthesis and structure-affinity relationships of novel small molecule natural product derivatives capable of discriminating between serotonin 5-HT1A, 5-HT2A, 5-HT2C receptor subtypes. Bioorg Med Chem. 2010 Jul 1;18(13):4783-92. DMAU1M5 RU https://pubmed.ncbi.nlm.nih.gov/20570529 DMAU1M5 DI DMAU1M5 DMAU1M5 DN (R,S)-1-(5-fluoro-1H-indol-1-yl)propan-2-amine DMAU1M5 MI TTWJBZ5 DMAU1M5 MN 5-HT 2C receptor (HTR2C) DMAU1M5 MT DTT DMAU1M5 MA Inhibitor DMAU1M5 RN Synthesis and structure-affinity relationships of novel small molecule natural product derivatives capable of discriminating between serotonin 5-HT1A, 5-HT2A, 5-HT2C receptor subtypes. Bioorg Med Chem. 2010 Jul 1;18(13):4783-92. DMAU1M5 RU https://pubmed.ncbi.nlm.nih.gov/20570529 DMS2DI9 DI DMS2DI9 DMS2DI9 DN (R,S)-1-(5-methyl-1H-indol-1-yl)propan-2-amine DMS2DI9 MI TTJQOD7 DMS2DI9 MN 5-HT 2A receptor (HTR2A) DMS2DI9 MT DTT DMS2DI9 MA Inhibitor DMS2DI9 RN Synthesis and structure-affinity relationships of novel small molecule natural product derivatives capable of discriminating between serotonin 5-HT1A, 5-HT2A, 5-HT2C receptor subtypes. Bioorg Med Chem. 2010 Jul 1;18(13):4783-92. DMS2DI9 RU https://pubmed.ncbi.nlm.nih.gov/20570529 DMS2DI9 DI DMS2DI9 DMS2DI9 DN (R,S)-1-(5-methyl-1H-indol-1-yl)propan-2-amine DMS2DI9 MI TTWJBZ5 DMS2DI9 MN 5-HT 2C receptor (HTR2C) DMS2DI9 MT DTT DMS2DI9 MA Inhibitor DMS2DI9 RN Synthesis and structure-affinity relationships of novel small molecule natural product derivatives capable of discriminating between serotonin 5-HT1A, 5-HT2A, 5-HT2C receptor subtypes. Bioorg Med Chem. 2010 Jul 1;18(13):4783-92. DMS2DI9 RU https://pubmed.ncbi.nlm.nih.gov/20570529 DM0YELX DI DM0YELX DM0YELX DN (R,S)-1-(6-fluoro-1H-indol-1-yl)propan-2-amine DM0YELX MI TTJQOD7 DM0YELX MN 5-HT 2A receptor (HTR2A) DM0YELX MT DTT DM0YELX MA Inhibitor DM0YELX RN Synthesis and structure-affinity relationships of novel small molecule natural product derivatives capable of discriminating between serotonin 5-HT1A, 5-HT2A, 5-HT2C receptor subtypes. Bioorg Med Chem. 2010 Jul 1;18(13):4783-92. DM0YELX RU https://pubmed.ncbi.nlm.nih.gov/20570529 DM0YELX DI DM0YELX DM0YELX DN (R,S)-1-(6-fluoro-1H-indol-1-yl)propan-2-amine DM0YELX MI TTWJBZ5 DM0YELX MN 5-HT 2C receptor (HTR2C) DM0YELX MT DTT DM0YELX MA Inhibitor DM0YELX RN Synthesis and structure-affinity relationships of novel small molecule natural product derivatives capable of discriminating between serotonin 5-HT1A, 5-HT2A, 5-HT2C receptor subtypes. Bioorg Med Chem. 2010 Jul 1;18(13):4783-92. DM0YELX RU https://pubmed.ncbi.nlm.nih.gov/20570529 DM7COSH DI DM7COSH DM7COSH DN (R,S)-4-phosphonophenylglycine DM7COSH MI TT0IFKL DM7COSH MN Metabotropic glutamate receptor 8 (mGluR8) DM7COSH MT DTT DM7COSH MA Agonist DM7COSH RN Anticonvulsant activity of a metabotropic glutamate receptor 8 preferential agonist, (R,S)-4-phosphonophenylglycine. Eur J Pharmacol. 1999 Oct 21;383(1):23-7. DM7COSH RU https://pubmed.ncbi.nlm.nih.gov/10556677 DMUG451 DI DMUG451 DMUG451 DN (R,S)-homoaromaline hydrochloride DMUG451 MI TTZFYLI DMUG451 MN Dopamine D1 receptor (D1R) DMUG451 MT DTT DMUG451 MA Inhibitor DMUG451 RN Displacement activity of bisbenzylisoquinoline alkaloids at striatal 3H-SCH 23390 and 3H-raclopride binding sites. J Nat Prod. 1992 Sep;55(9):1281-6. DMUG451 RU https://pubmed.ncbi.nlm.nih.gov/1431946 DMPDO43 DI DMPDO43 DMPDO43 DN (R,S)-N-(R-phenylethyl)-1H-pyrrole-2-carboxamide DMPDO43 MI TT3WG5C DMPDO43 MN Monoamine oxidase type A (MAO-A) DMPDO43 MT DTT DMPDO43 MA Inhibitor DMPDO43 RN New pyrrole inhibitors of monoamine oxidase: synthesis, biological evaluation, and structural determinants of MAO-A and MAO-B selectivity. J Med Chem. 2007 Mar 8;50(5):922-31. DMPDO43 RU https://pubmed.ncbi.nlm.nih.gov/17256833 DMQO71C DI DMQO71C DMQO71C DN (R,S)-PHPNECA DMQO71C MI TTK25J1 DMQO71C MN Adenosine A1 receptor (ADORA1) DMQO71C MT DTT DMQO71C MA Agonist DMQO71C RN N(6)-alkyl-2-alkynyl derivatives of adenosine as potent and selective agonists at the human adenosine A(3) receptor and a starting point for searching A(2B) ligands. J Med Chem. 2002 Jul 18;45(15):3271-9. DMQO71C RU https://pubmed.ncbi.nlm.nih.gov/12109910 DMQO71C DI DMQO71C DMQO71C DN (R,S)-PHPNECA DMQO71C MI TTNE7KG DMQO71C MN Adenosine A2b receptor (ADORA2B) DMQO71C MT DTT DMQO71C MA Agonist DMQO71C RN N(6)-alkyl-2-alkynyl derivatives of adenosine as potent and selective agonists at the human adenosine A(3) receptor and a starting point for searching A(2B) ligands. J Med Chem. 2002 Jul 18;45(15):3271-9. DMQO71C RU https://pubmed.ncbi.nlm.nih.gov/12109910 DMQO71C DI DMQO71C DMQO71C DN (R,S)-PHPNECA DMQO71C MI TTJFY5U DMQO71C MN Adenosine A3 receptor (ADORA3) DMQO71C MT DTT DMQO71C MA Agonist DMQO71C RN N(6)-alkyl-2-alkynyl derivatives of adenosine as potent and selective agonists at the human adenosine A(3) receptor and a starting point for searching A(2B) ligands. J Med Chem. 2002 Jul 18;45(15):3271-9. DMQO71C RU https://pubmed.ncbi.nlm.nih.gov/12109910 DM8I6MG DI DM8I6MG DM8I6MG DN (R/R)BEFLOXATONE DM8I6MG MI TT3WG5C DM8I6MG MN Monoamine oxidase type A (MAO-A) DM8I6MG MT DTT DM8I6MG MA Inhibitor DM8I6MG RN 3-(1H-Pyrrol-1-yl)-2-oxazolidinones as reversible, highly potent, and selective inhibitors of monoamine oxidase type A. J Med Chem. 2002 Mar 14;45(6):1180-3. DM8I6MG RU https://pubmed.ncbi.nlm.nih.gov/11881986 DM8I6MG DI DM8I6MG DM8I6MG DN (R/R)BEFLOXATONE DM8I6MG MI TTGP7BY DM8I6MG MN Monoamine oxidase type B (MAO-B) DM8I6MG MT DTT DM8I6MG MA Inhibitor DM8I6MG RN 3-(1H-Pyrrol-1-yl)-2-oxazolidinones as reversible, highly potent, and selective inhibitors of monoamine oxidase type A. J Med Chem. 2002 Mar 14;45(6):1180-3. DM8I6MG RU https://pubmed.ncbi.nlm.nih.gov/11881986 DMYDG27 DI DMYDG27 DMYDG27 DN (R/S) EF-1500 DMYDG27 MI TTPRKM0 DMYDG27 MN GABA transporter GAT-1 (SLC6A1) DMYDG27 MT DTT DMYDG27 MA Inhibitor DMYDG27 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 929). DMYDG27 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=929 DMYDG27 DI DMYDG27 DMYDG27 DN (R/S) EF-1500 DMYDG27 MI TTQBMPI DMYDG27 MN Na(+)/Cl(-) betaine/GABA transporter (SLC6A12) DMYDG27 MT DTT DMYDG27 MA Inhibitor DMYDG27 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 932). DMYDG27 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=932 DM3MEQB DI DM3MEQB DM3MEQB DN (R/S)-2-((4-benzylphenoxy)methyl)piperazine DM3MEQB MI TTXZEAJ DM3MEQB MN Leukotriene A-4 hydrolase (LTA4H) DM3MEQB MT DTT DM3MEQB MA Inhibitor DM3MEQB RN Discovery of novel leukotriene A4 hydrolase inhibitors based on piperidine and piperazine scaffolds. Bioorg Med Chem Lett. 2010 May 1;20(9):2851-4. DM3MEQB RU https://pubmed.ncbi.nlm.nih.gov/20371179 DMRXD82 DI DMRXD82 DMRXD82 DN (R/S)-2-((4-benzylphenoxy)methyl)piperidine DMRXD82 MI TTXZEAJ DMRXD82 MN Leukotriene A-4 hydrolase (LTA4H) DMRXD82 MT DTT DMRXD82 MA Inhibitor DMRXD82 RN Discovery of novel leukotriene A4 hydrolase inhibitors based on piperidine and piperazine scaffolds. Bioorg Med Chem Lett. 2010 May 1;20(9):2851-4. DMRXD82 RU https://pubmed.ncbi.nlm.nih.gov/20371179 DMDA285 DI DMDA285 DMDA285 DN (R/S)-2-((4-phenoxyphenoxy)methyl)piperidine DMDA285 MI TTXZEAJ DMDA285 MN Leukotriene A-4 hydrolase (LTA4H) DMDA285 MT DTT DMDA285 MA Inhibitor DMDA285 RN Discovery of novel leukotriene A4 hydrolase inhibitors based on piperidine and piperazine scaffolds. Bioorg Med Chem Lett. 2010 May 1;20(9):2851-4. DMDA285 RU https://pubmed.ncbi.nlm.nih.gov/20371179 DMYZCRF DI DMYZCRF DMYZCRF DN (RS)-(tetrazol-5-yl)glycine DMYZCRF MI TTLD29N DMYZCRF MN Glutamate receptor ionotropic NMDA 1 (NMDAR1) DMYZCRF MT DTT DMYZCRF MA Agonist DMYZCRF RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 455). DMYZCRF RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=455 DMYZCRF DI DMYZCRF DMYZCRF DN (RS)-(tetrazol-5-yl)glycine DMYZCRF MI TTKJEMQ DMYZCRF MN Glutamate receptor ionotropic NMDA 2A (NMDAR2A) DMYZCRF MT DTT DMYZCRF MA Agonist DMYZCRF RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 456). DMYZCRF RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=456 DMYZCRF DI DMYZCRF DMYZCRF DN (RS)-(tetrazol-5-yl)glycine DMYZCRF MI TTN9D8E DMYZCRF MN Glutamate receptor ionotropic NMDA 2B (NMDAR2B) DMYZCRF MT DTT DMYZCRF MA Agonist DMYZCRF RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 457). DMYZCRF RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=457 DMYZCRF DI DMYZCRF DMYZCRF DN (RS)-(tetrazol-5-yl)glycine DMYZCRF MI TT1M8OW DMYZCRF MN Glutamate receptor ionotropic NMDA 2C (GluN2C) DMYZCRF MT DTT DMYZCRF MA Agonist DMYZCRF RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 458). DMYZCRF RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=458 DMYZCRF DI DMYZCRF DMYZCRF DN (RS)-(tetrazol-5-yl)glycine DMYZCRF MI TT5POTG DMYZCRF MN Glutamate receptor ionotropic NMDA 2D (GluN2D) DMYZCRF MT DTT DMYZCRF MA Agonist DMYZCRF RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 459). DMYZCRF RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=459 DMCPEBF DI DMCPEBF DMCPEBF DN (RS)-5-diphosphomevalonate DMCPEBF MI TT5DFHW DMCPEBF MN Mevalonate kinase (MVK) DMCPEBF MT DTT DMCPEBF MA Inhibitor DMCPEBF RN Bifunctional inhibitors of mevalonate kinase and mevalonate 5-diphosphate decarboxylase. Org Lett. 2006 Mar 16;8(6):1013-6. DMCPEBF RU https://pubmed.ncbi.nlm.nih.gov/16524256 DMA8DEG DI DMA8DEG DMA8DEG DN (RS)-PPCC DMA8DEG MI TT5TPI6 DMA8DEG MN Opioid receptor sigma 1 (OPRS1) DMA8DEG MT DTT DMA8DEG MA Agonist DMA8DEG RN Novel sigma receptor ligands: synthesis and biological profile. J Med Chem. 2007 Mar 8;50(5):951-61. DMA8DEG RU https://pubmed.ncbi.nlm.nih.gov/17328523 DMCN6WR DI DMCN6WR DMCN6WR DN (RS)-tacrine(10)-hupyridone DMCN6WR MI TT1RS9F DMCN6WR MN Acetylcholinesterase (AChE) DMCN6WR MT DTT DMCN6WR MA Inhibitor DMCN6WR RN Exploiting protein fluctuations at the active-site gorge of human cholinesterases: further optimization of the design strategy to develop extremely... J Med Chem. 2008 Jun 12;51(11):3154-70. DMCN6WR RU https://pubmed.ncbi.nlm.nih.gov/18479118 DMCN6WR DI DMCN6WR DMCN6WR DN (RS)-tacrine(10)-hupyridone DMCN6WR MI TTEB0GD DMCN6WR MN Cholinesterase (BCHE) DMCN6WR MT DTT DMCN6WR MA Inhibitor DMCN6WR RN Exploiting protein fluctuations at the active-site gorge of human cholinesterases: further optimization of the design strategy to develop extremely... J Med Chem. 2008 Jun 12;51(11):3154-70. DMCN6WR RU https://pubmed.ncbi.nlm.nih.gov/18479118 DM6EYQ2 DI DM6EYQ2 DM6EYQ2 DN (RS/SR)-2-[1-(3,4-dichlorophenyl)butyl]piperidine DM6EYQ2 MI TTVBI8W DM6EYQ2 MN Dopamine transporter (DAT) DM6EYQ2 MT DTT DM6EYQ2 MA Inhibitor DM6EYQ2 RN Slow-onset, long-duration, alkyl analogues of methylphenidate with enhanced selectivity for the dopamine transporter. J Med Chem. 2007 Jan 25;50(2):219-32. DM6EYQ2 RU https://pubmed.ncbi.nlm.nih.gov/17228864 DMGHWJ5 DI DMGHWJ5 DMGHWJ5 DN (RS/SR)-2-[1-(4-chlorophenyl)butyl]piperidine DMGHWJ5 MI TTVBI8W DMGHWJ5 MN Dopamine transporter (DAT) DMGHWJ5 MT DTT DMGHWJ5 MA Inhibitor DMGHWJ5 RN Slow-onset, long-duration, alkyl analogues of methylphenidate with enhanced selectivity for the dopamine transporter. J Med Chem. 2007 Jan 25;50(2):219-32. DMGHWJ5 RU https://pubmed.ncbi.nlm.nih.gov/17228864 DMAIGM2 DI DMAIGM2 DMAIGM2 DN (RS/SR)-2-[1-(4-chlorophenyl)ethyl]piperidine DMAIGM2 MI TTVBI8W DMAIGM2 MN Dopamine transporter (DAT) DMAIGM2 MT DTT DMAIGM2 MA Inhibitor DMAIGM2 RN Slow-onset, long-duration, alkyl analogues of methylphenidate with enhanced selectivity for the dopamine transporter. J Med Chem. 2007 Jan 25;50(2):219-32. DMAIGM2 RU https://pubmed.ncbi.nlm.nih.gov/17228864 DMDVMSP DI DMDVMSP DMDVMSP DN (RS/SR)-2-[1-(4-chlorophenyl)hexyl]piperidine DMDVMSP MI TTVBI8W DMDVMSP MN Dopamine transporter (DAT) DMDVMSP MT DTT DMDVMSP MA Inhibitor DMDVMSP RN Slow-onset, long-duration, alkyl analogues of methylphenidate with enhanced selectivity for the dopamine transporter. J Med Chem. 2007 Jan 25;50(2):219-32. DMDVMSP RU https://pubmed.ncbi.nlm.nih.gov/17228864 DMMUV7R DI DMMUV7R DMMUV7R DN (RS/SR)-2-[1-(4-chlorophenyl)pentyl]piperidine DMMUV7R MI TTVBI8W DMMUV7R MN Dopamine transporter (DAT) DMMUV7R MT DTT DMMUV7R MA Inhibitor DMMUV7R RN Slow-onset, long-duration, alkyl analogues of methylphenidate with enhanced selectivity for the dopamine transporter. J Med Chem. 2007 Jan 25;50(2):219-32. DMMUV7R RU https://pubmed.ncbi.nlm.nih.gov/17228864 DMPQAGL DI DMPQAGL DMPQAGL DN (RS/SR)-2-[1-(4-chlorophenyl)propyl]piperidine DMPQAGL MI TTVBI8W DMPQAGL MN Dopamine transporter (DAT) DMPQAGL MT DTT DMPQAGL MA Inhibitor DMPQAGL RN Slow-onset, long-duration, alkyl analogues of methylphenidate with enhanced selectivity for the dopamine transporter. J Med Chem. 2007 Jan 25;50(2):219-32. DMPQAGL RU https://pubmed.ncbi.nlm.nih.gov/17228864 DML1GP5 DI DML1GP5 DML1GP5 DN (S-(2-oxo)pentadecyl-CoA) DML1GP5 MI TTBAF05 DML1GP5 MN Candida Peptide N-myristoyltransferase (Candi NMT1) DML1GP5 MT DTT DML1GP5 MA Inhibitor DML1GP5 RN Crystal structures of Saccharomyces cerevisiae N-myristoyltransferase with bound myristoyl-CoA and inhibitors reveal the functional roles of the N-... J Biol Chem. 2007 Jul 27;282(30):22185-94. DML1GP5 RU https://pubmed.ncbi.nlm.nih.gov/17513302 DMUNQY7 DI DMUNQY7 DMUNQY7 DN (S)-(-)-(4,5,6-trimethoxyindan-1-yl)methanamine DMUNQY7 MI TTJQOD7 DMUNQY7 MN 5-HT 2A receptor (HTR2A) DMUNQY7 MT DTT DMUNQY7 MA Inhibitor DMUNQY7 RN C-(4,5,6-trimethoxyindan-1-yl)methanamine: a mescaline analogue designed using a homology model of the 5-HT2A receptor. J Med Chem. 2006 Jul 13;49(14):4269-74. DMUNQY7 RU https://pubmed.ncbi.nlm.nih.gov/16821786 DMC5Z2I DI DMC5Z2I DMC5Z2I DN (S)(+)-2-(4-fluorophenyl)-7-methoxychroman-4-one DMC5Z2I MI TTGP7BY DMC5Z2I MN Monoamine oxidase type B (MAO-B) DMC5Z2I MT DTT DMC5Z2I MA Inhibitor DMC5Z2I RN A new series of flavones, thioflavones, and flavanones as selective monoamine oxidase-B inhibitors. Bioorg Med Chem. 2010 Feb;18(3):1273-9. DMC5Z2I RU https://pubmed.ncbi.nlm.nih.gov/20045650 DMILWE7 DI DMILWE7 DMILWE7 DN (S)(+)-7-fluoro-2-(4-fluorophenyl)chroman-4-one DMILWE7 MI TTGP7BY DMILWE7 MN Monoamine oxidase type B (MAO-B) DMILWE7 MT DTT DMILWE7 MA Inhibitor DMILWE7 RN A new series of flavones, thioflavones, and flavanones as selective monoamine oxidase-B inhibitors. Bioorg Med Chem. 2010 Feb;18(3):1273-9. DMILWE7 RU https://pubmed.ncbi.nlm.nih.gov/20045650 DMHR1IB DI DMHR1IB DMHR1IB DN (S)(+)-7-fluoro-2-phenylchroman-4-one DMHR1IB MI TTGP7BY DMHR1IB MN Monoamine oxidase type B (MAO-B) DMHR1IB MT DTT DMHR1IB MA Inhibitor DMHR1IB RN A new series of flavones, thioflavones, and flavanones as selective monoamine oxidase-B inhibitors. Bioorg Med Chem. 2010 Feb;18(3):1273-9. DMHR1IB RU https://pubmed.ncbi.nlm.nih.gov/20045650 DMTFZBQ DI DMTFZBQ DMTFZBQ DN (S)(+)-7-fluoro-2-p-tolylchroman-4-one DMTFZBQ MI TTGP7BY DMTFZBQ MN Monoamine oxidase type B (MAO-B) DMTFZBQ MT DTT DMTFZBQ MA Inhibitor DMTFZBQ RN A new series of flavones, thioflavones, and flavanones as selective monoamine oxidase-B inhibitors. Bioorg Med Chem. 2010 Feb;18(3):1273-9. DMTFZBQ RU https://pubmed.ncbi.nlm.nih.gov/20045650 DMBG4KN DI DMBG4KN DMBG4KN DN (S)(+)-7-methyl-2-phenylchroman-4-one DMBG4KN MI TTGP7BY DMBG4KN MN Monoamine oxidase type B (MAO-B) DMBG4KN MT DTT DMBG4KN MA Inhibitor DMBG4KN RN A new series of flavones, thioflavones, and flavanones as selective monoamine oxidase-B inhibitors. Bioorg Med Chem. 2010 Feb;18(3):1273-9. DMBG4KN RU https://pubmed.ncbi.nlm.nih.gov/20045650 DMVBD6H DI DMVBD6H DMVBD6H DN (S)(+)-7-methyl-2-p-tolylchroman-4-one DMVBD6H MI TTGP7BY DMVBD6H MN Monoamine oxidase type B (MAO-B) DMVBD6H MT DTT DMVBD6H MA Inhibitor DMVBD6H RN A new series of flavones, thioflavones, and flavanones as selective monoamine oxidase-B inhibitors. Bioorg Med Chem. 2010 Feb;18(3):1273-9. DMVBD6H RU https://pubmed.ncbi.nlm.nih.gov/20045650 DMPDOY8 DI DMPDOY8 DMPDOY8 DN (S)-(+)-CBPG DMPDOY8 MI TTVBPDM DMPDOY8 MN Metabotropic glutamate receptor 1 (mGluR1) DMPDOY8 MT DTT DMPDOY8 MA Antagonist DMPDOY8 RN Biochemical and electrophysiological studies on (S)-(+)-2-(3'-carboxybicyclo(1.1.1)pentyl)-glycine (CBPG), a novel mGlu5 receptor agonist endowed with mGlu1 receptor antagonist activity. Neuropharmacology. 1999 Jul;38(7):917-26. DMPDOY8 RU https://pubmed.ncbi.nlm.nih.gov/10428410 DMPDOY8 DI DMPDOY8 DMPDOY8 DN (S)-(+)-CBPG DMPDOY8 MI TTHS256 DMPDOY8 MN Metabotropic glutamate receptor 5 (mGluR5) DMPDOY8 MT DTT DMPDOY8 MA Agonist DMPDOY8 RN Biochemical and electrophysiological studies on (S)-(+)-2-(3'-carboxybicyclo(1.1.1)pentyl)-glycine (CBPG), a novel mGlu5 receptor agonist endowed with mGlu1 receptor antagonist activity. Neuropharmacology. 1999 Jul;38(7):917-26. DMPDOY8 RU https://pubmed.ncbi.nlm.nih.gov/10428410 DMF2IY8 DI DMF2IY8 DMF2IY8 DN (S)-1-(1H-indazol-4-yl)-3-(1-p-tolylethyl)urea DMF2IY8 MI TTMI6F5 DMF2IY8 MN Transient receptor potential cation channel V1 (TRPV1) DMF2IY8 MT DTT DMF2IY8 MA Inhibitor DMF2IY8 RN Alpha-methylation at benzylic fragment of N-aryl-N'-benzyl ureas provides TRPV1 antagonists with better pharmacokinetic properties and higher effic... Bioorg Med Chem Lett. 2007 Jul 15;17(14):3894-9. DMF2IY8 RU https://pubmed.ncbi.nlm.nih.gov/17507218 DMF9YLR DI DMF9YLR DMF9YLR DN (S)-1-(2-methoxyphenethyl)-2-methylpyrrolidine DMF9YLR MI TT9JNIC DMF9YLR MN Histamine H3 receptor (H3R) DMF9YLR MT DTT DMF9YLR MA Inhibitor DMF9YLR RN In vitro SAR of pyrrolidine-containing histamine H3 receptor antagonists: trends across multiple chemical series. Bioorg Med Chem Lett. 2008 Jan 1;18(1):355-9. DMF9YLR RU https://pubmed.ncbi.nlm.nih.gov/18077160 DM8UWT9 DI DM8UWT9 DM8UWT9 DN (S)-1-(3-methoxyphenethyl)-2-methylpyrrolidine DM8UWT9 MI TT9JNIC DM8UWT9 MN Histamine H3 receptor (H3R) DM8UWT9 MT DTT DM8UWT9 MA Inhibitor DM8UWT9 RN In vitro SAR of pyrrolidine-containing histamine H3 receptor antagonists: trends across multiple chemical series. Bioorg Med Chem Lett. 2008 Jan 1;18(1):355-9. DM8UWT9 RU https://pubmed.ncbi.nlm.nih.gov/18077160 DMDBHY1 DI DMDBHY1 DMDBHY1 DN (S)-1-(4-methoxyphenethyl)-2-methylpyrrolidine DMDBHY1 MI TT9JNIC DMDBHY1 MN Histamine H3 receptor (H3R) DMDBHY1 MT DTT DMDBHY1 MA Inhibitor DMDBHY1 RN In vitro SAR of pyrrolidine-containing histamine H3 receptor antagonists: trends across multiple chemical series. Bioorg Med Chem Lett. 2008 Jan 1;18(1):355-9. DMDBHY1 RU https://pubmed.ncbi.nlm.nih.gov/18077160 DMG7XL5 DI DMG7XL5 DMG7XL5 DN (S)-1-(4-nitrophenethyl)-2-methylpyrrolidine DMG7XL5 MI TT9JNIC DMG7XL5 MN Histamine H3 receptor (H3R) DMG7XL5 MT DTT DMG7XL5 MA Inhibitor DMG7XL5 RN In vitro SAR of pyrrolidine-containing histamine H3 receptor antagonists: trends across multiple chemical series. Bioorg Med Chem Lett. 2008 Jan 1;18(1):355-9. DMG7XL5 RU https://pubmed.ncbi.nlm.nih.gov/18077160 DMEIB8F DI DMEIB8F DMEIB8F DN (S)-1-(5,6-difluoro-1H-indol-1-yl)propan-2-amine DMEIB8F MI TTJQOD7 DMEIB8F MN 5-HT 2A receptor (HTR2A) DMEIB8F MT DTT DMEIB8F MA Inhibitor DMEIB8F RN Synthesis and structure-affinity relationships of novel small molecule natural product derivatives capable of discriminating between serotonin 5-HT1A, 5-HT2A, 5-HT2C receptor subtypes. Bioorg Med Chem. 2010 Jul 1;18(13):4783-92. DMEIB8F RU https://pubmed.ncbi.nlm.nih.gov/20570529 DMEIB8F DI DMEIB8F DMEIB8F DN (S)-1-(5,6-difluoro-1H-indol-1-yl)propan-2-amine DMEIB8F MI TTWJBZ5 DMEIB8F MN 5-HT 2C receptor (HTR2C) DMEIB8F MT DTT DMEIB8F MA Inhibitor DMEIB8F RN Synthesis and structure-affinity relationships of novel small molecule natural product derivatives capable of discriminating between serotonin 5-HT1A, 5-HT2A, 5-HT2C receptor subtypes. Bioorg Med Chem. 2010 Jul 1;18(13):4783-92. DMEIB8F RU https://pubmed.ncbi.nlm.nih.gov/20570529 DM1U7MC DI DM1U7MC DM1U7MC DN (S)-1,7-Diphenyl-6(E)-hepten-3-ol DM1U7MC MI TT50QJ3 DM1U7MC MN Influenza Neuraminidase (Influ NA) DM1U7MC MT DTT DM1U7MC MA Inhibitor DM1U7MC RN Antiviral potential and molecular insight into neuraminidase inhibiting diarylheptanoids from Alpinia katsumadai. J Med Chem. 2010 Jan 28;53(2):778-86. DM1U7MC RU https://pubmed.ncbi.nlm.nih.gov/20014777 DMICUQK DI DMICUQK DMICUQK DN (S)-1-benzylcyclopentyl 1-oxohexan-2-ylcarbamate DMICUQK MI TTF2LRI DMICUQK MN Cathepsin B (CTSB) DMICUQK MT DTT DMICUQK MA Inhibitor DMICUQK RN Semicarbazone-based inhibitors of cathepsin K, are they prodrugs for aldehyde inhibitors Bioorg Med Chem Lett. 2006 Feb 15;16(4):978-83. DMICUQK RU https://pubmed.ncbi.nlm.nih.gov/16290936 DMICUQK DI DMICUQK DMICUQK DN (S)-1-benzylcyclopentyl 1-oxohexan-2-ylcarbamate DMICUQK MI TTDZN01 DMICUQK MN Cathepsin K (CTSK) DMICUQK MT DTT DMICUQK MA Inhibitor DMICUQK RN Semicarbazone-based inhibitors of cathepsin K, are they prodrugs for aldehyde inhibitors Bioorg Med Chem Lett. 2006 Feb 15;16(4):978-83. DMICUQK RU https://pubmed.ncbi.nlm.nih.gov/16290936 DMICUQK DI DMICUQK DMICUQK DN (S)-1-benzylcyclopentyl 1-oxohexan-2-ylcarbamate DMICUQK MI TT36ETB DMICUQK MN Cathepsin L (CTSL) DMICUQK MT DTT DMICUQK MA Inhibitor DMICUQK RN Semicarbazone-based inhibitors of cathepsin K, are they prodrugs for aldehyde inhibitors Bioorg Med Chem Lett. 2006 Feb 15;16(4):978-83. DMICUQK RU https://pubmed.ncbi.nlm.nih.gov/16290936 DM2VOAS DI DM2VOAS DM2VOAS DN (S)-2-((4-phenoxyphenoxy)methyl)piperidine DM2VOAS MI TTXZEAJ DM2VOAS MN Leukotriene A-4 hydrolase (LTA4H) DM2VOAS MT DTT DM2VOAS MA Inhibitor DM2VOAS RN Discovery of novel leukotriene A4 hydrolase inhibitors based on piperidine and piperazine scaffolds. Bioorg Med Chem Lett. 2010 May 1;20(9):2851-4. DM2VOAS RU https://pubmed.ncbi.nlm.nih.gov/20371179 DMQGCKX DI DMQGCKX DMQGCKX DN (S)-2-(2-(2-methylpyrrolidin-1-yl)ethyl)phenol DMQGCKX MI TT9JNIC DMQGCKX MN Histamine H3 receptor (H3R) DMQGCKX MT DTT DMQGCKX MA Inhibitor DMQGCKX RN In vitro SAR of pyrrolidine-containing histamine H3 receptor antagonists: trends across multiple chemical series. Bioorg Med Chem Lett. 2008 Jan 1;18(1):355-9. DMQGCKX RU https://pubmed.ncbi.nlm.nih.gov/18077160 DMVKL84 DI DMVKL84 DMVKL84 DN (S)-2-(2-(2-methylpyrrolidin-1-yl)ethyl)pyridine DMVKL84 MI TT9JNIC DMVKL84 MN Histamine H3 receptor (H3R) DMVKL84 MT DTT DMVKL84 MA Inhibitor DMVKL84 RN In vitro SAR of pyrrolidine-containing histamine H3 receptor antagonists: trends across multiple chemical series. Bioorg Med Chem Lett. 2008 Jan 1;18(1):355-9. DMVKL84 RU https://pubmed.ncbi.nlm.nih.gov/18077160 DMPQ53V DI DMPQ53V DMPQ53V DN (S)-2-amino-1-(4-butylthiophenyl)-propane DMPQ53V MI TT3WG5C DMPQ53V MN Monoamine oxidase type A (MAO-A) DMPQ53V MT DTT DMPQ53V MA Inhibitor DMPQ53V RN Human and rat monoamine oxidase-A are differentially inhibited by (S)-4-alkylthioamphetamine derivatives: insights from molecular modeling studies. Bioorg Med Chem. 2007 Aug 1;15(15):5198-206. DMPQ53V RU https://pubmed.ncbi.nlm.nih.gov/17521909 DMPQ53V DI DMPQ53V DMPQ53V DN (S)-2-amino-1-(4-butylthiophenyl)-propane DMPQ53V MI TTGP7BY DMPQ53V MN Monoamine oxidase type B (MAO-B) DMPQ53V MT DTT DMPQ53V MA Inhibitor DMPQ53V RN Human and rat monoamine oxidase-A are differentially inhibited by (S)-4-alkylthioamphetamine derivatives: insights from molecular modeling studies. Bioorg Med Chem. 2007 Aug 1;15(15):5198-206. DMPQ53V RU https://pubmed.ncbi.nlm.nih.gov/17521909 DMFK7O1 DI DMFK7O1 DMFK7O1 DN (S)-2-amino-1-(4-ethylthiophenyl)-propane DMFK7O1 MI TT3WG5C DMFK7O1 MN Monoamine oxidase type A (MAO-A) DMFK7O1 MT DTT DMFK7O1 MA Inhibitor DMFK7O1 RN Human and rat monoamine oxidase-A are differentially inhibited by (S)-4-alkylthioamphetamine derivatives: insights from molecular modeling studies. Bioorg Med Chem. 2007 Aug 1;15(15):5198-206. DMFK7O1 RU https://pubmed.ncbi.nlm.nih.gov/17521909 DM06NUM DI DM06NUM DM06NUM DN (S)-2-amino-1-(4-methylthiophenyl)-propane DM06NUM MI TT3WG5C DM06NUM MN Monoamine oxidase type A (MAO-A) DM06NUM MT DTT DM06NUM MA Inhibitor DM06NUM RN Human and rat monoamine oxidase-A are differentially inhibited by (S)-4-alkylthioamphetamine derivatives: insights from molecular modeling studies. Bioorg Med Chem. 2007 Aug 1;15(15):5198-206. DM06NUM RU https://pubmed.ncbi.nlm.nih.gov/17521909 DMAN7YJ DI DMAN7YJ DMAN7YJ DN (S)-2-amino-1-(4-propylthiophenyl)-propane DMAN7YJ MI TT3WG5C DMAN7YJ MN Monoamine oxidase type A (MAO-A) DMAN7YJ MT DTT DMAN7YJ MA Inhibitor DMAN7YJ RN Human and rat monoamine oxidase-A are differentially inhibited by (S)-4-alkylthioamphetamine derivatives: insights from molecular modeling studies. Bioorg Med Chem. 2007 Aug 1;15(15):5198-206. DMAN7YJ RU https://pubmed.ncbi.nlm.nih.gov/17521909 DMAN7YJ DI DMAN7YJ DMAN7YJ DN (S)-2-amino-1-(4-propylthiophenyl)-propane DMAN7YJ MI TTGP7BY DMAN7YJ MN Monoamine oxidase type B (MAO-B) DMAN7YJ MT DTT DMAN7YJ MA Inhibitor DMAN7YJ RN Human and rat monoamine oxidase-A are differentially inhibited by (S)-4-alkylthioamphetamine derivatives: insights from molecular modeling studies. Bioorg Med Chem. 2007 Aug 1;15(15):5198-206. DMAN7YJ RU https://pubmed.ncbi.nlm.nih.gov/17521909 DMWBH9N DI DMWBH9N DMWBH9N DN (S)-2-Amino-1-azetidin-1-yl-2-cyclohexyl-ethanone DMWBH9N MI TTDIGC1 DMWBH9N MN Dipeptidyl peptidase 4 (DPP-4) DMWBH9N MT DTT DMWBH9N MA Inhibitor DMWBH9N RN New fluorinated pyrrolidine and azetidine amides as dipeptidyl peptidase IV inhibitors. Bioorg Med Chem Lett. 2005 Nov 1;15(21):4770-3. DMWBH9N RU https://pubmed.ncbi.nlm.nih.gov/16115768 DMORFZE DI DMORFZE DMORFZE DN (S)-2-Amino-1-thiazolidin-3-yl-propane-1-thione DMORFZE MI TTDIGC1 DMORFZE MN Dipeptidyl peptidase 4 (DPP-4) DMORFZE MT DTT DMORFZE MA Inhibitor DMORFZE RN Development of potent and selective dipeptidyl peptidase II inhibitors. Bioorg Med Chem Lett. 2002 Oct 21;12(20):2825-8. DMORFZE RU https://pubmed.ncbi.nlm.nih.gov/12270155 DMVD05E DI DMVD05E DMVD05E DN (S)-2-amino-2-cyclohexylacetic acid DMVD05E MI TTFK1JQ DMVD05E MN Voltage-gated calcium channel alpha-2/delta-1 (CACNA2D1) DMVD05E MT DTT DMVD05E MA Inhibitor DMVD05E RN Structure-activity relationships of alpha-amino acid ligands for the alpha2delta subunit of voltage-gated calcium channels. Bioorg Med Chem Lett. 2006 Mar 1;16(5):1138-41. DMVD05E RU https://pubmed.ncbi.nlm.nih.gov/16380257 DMG9KMN DI DMG9KMN DMG9KMN DN (S)-2-amino-2-o-tolylacetic acid DMG9KMN MI TTFK1JQ DMG9KMN MN Voltage-gated calcium channel alpha-2/delta-1 (CACNA2D1) DMG9KMN MT DTT DMG9KMN MA Inhibitor DMG9KMN RN Structure-activity relationships of alpha-amino acid ligands for the alpha2delta subunit of voltage-gated calcium channels. Bioorg Med Chem Lett. 2006 Mar 1;16(5):1138-41. DMG9KMN RU https://pubmed.ncbi.nlm.nih.gov/16380257 DMFEGPX DI DMFEGPX DMFEGPX DN (S)-2-Amino-2-phenyl-ethanethiol DMFEGPX MI TTPHMWB DMFEGPX MN Aminopeptidase N (ANPEP) DMFEGPX MT DTT DMFEGPX MA Inhibitor DMFEGPX RN Design of the first highly potent and selective aminopeptidase N (EC 3.4.11.2) inhibitor. Bioorg Med Chem Lett. 1999 Jun 7;9(11):1511-6. DMFEGPX RU https://pubmed.ncbi.nlm.nih.gov/10386926 DM2104G DI DM2104G DM2104G DN (S)-2-amino-2-phenylpropanoic acid DM2104G MI TTFK1JQ DM2104G MN Voltage-gated calcium channel alpha-2/delta-1 (CACNA2D1) DM2104G MT DTT DM2104G MA Inhibitor DM2104G RN Structure-activity relationships of alpha-amino acid ligands for the alpha2delta subunit of voltage-gated calcium channels. Bioorg Med Chem Lett. 2006 Mar 1;16(5):1138-41. DM2104G RU https://pubmed.ncbi.nlm.nih.gov/16380257 DMCDZ8A DI DMCDZ8A DMCDZ8A DN (S)-2-amino-2-p-tolylacetic acid DMCDZ8A MI TTFK1JQ DMCDZ8A MN Voltage-gated calcium channel alpha-2/delta-1 (CACNA2D1) DMCDZ8A MT DTT DMCDZ8A MA Inhibitor DMCDZ8A RN Structure-activity relationships of alpha-amino acid ligands for the alpha2delta subunit of voltage-gated calcium channels. Bioorg Med Chem Lett. 2006 Mar 1;16(5):1138-41. DMCDZ8A RU https://pubmed.ncbi.nlm.nih.gov/16380257 DM6OUW0 DI DM6OUW0 DM6OUW0 DN (S)-2-amino-3-(benzylthio)propanoic acid DM6OUW0 MI TTFK1JQ DM6OUW0 MN Voltage-gated calcium channel alpha-2/delta-1 (CACNA2D1) DM6OUW0 MT DTT DM6OUW0 MA Inhibitor DM6OUW0 RN Structure-activity relationships of alpha-amino acid ligands for the alpha2delta subunit of voltage-gated calcium channels. Bioorg Med Chem Lett. 2006 Mar 1;16(5):1138-41. DM6OUW0 RU https://pubmed.ncbi.nlm.nih.gov/16380257 DM1GBX8 DI DM1GBX8 DM1GBX8 DN (S)-2-amino-3-cyclohexylpropanoic acid DM1GBX8 MI TTFK1JQ DM1GBX8 MN Voltage-gated calcium channel alpha-2/delta-1 (CACNA2D1) DM1GBX8 MT DTT DM1GBX8 MA Inhibitor DM1GBX8 RN Structure-activity relationships of alpha-amino acid ligands for the alpha2delta subunit of voltage-gated calcium channels. Bioorg Med Chem Lett. 2006 Mar 1;16(5):1138-41. DM1GBX8 RU https://pubmed.ncbi.nlm.nih.gov/16380257 DMMAUKO DI DMMAUKO DMMAUKO DN (S)-2-Amino-3-phenyl-propane-1-thiol DMMAUKO MI TTPHMWB DMMAUKO MN Aminopeptidase N (ANPEP) DMMAUKO MT DTT DMMAUKO MA Inhibitor DMMAUKO RN Design of the first highly potent and selective aminopeptidase N (EC 3.4.11.2) inhibitor. Bioorg Med Chem Lett. 1999 Jun 7;9(11):1511-6. DMMAUKO RU https://pubmed.ncbi.nlm.nih.gov/10386926 DMF8I2W DI DMF8I2W DMF8I2W DN (S)-2-amino-4-(benzylthio)butanoic acid DMF8I2W MI TTFK1JQ DMF8I2W MN Voltage-gated calcium channel alpha-2/delta-1 (CACNA2D1) DMF8I2W MT DTT DMF8I2W MA Inhibitor DMF8I2W RN Structure-activity relationships of alpha-amino acid ligands for the alpha2delta subunit of voltage-gated calcium channels. Bioorg Med Chem Lett. 2006 Mar 1;16(5):1138-41. DMF8I2W RU https://pubmed.ncbi.nlm.nih.gov/16380257 DM8A1HG DI DM8A1HG DM8A1HG DN (S)-2-amino-4-hydroxy-N-(4-octylphenyl)butanamide DM8A1HG MI TTCN0M9 DM8A1HG MN Sphingosine kinase 2 (SPHK2) DM8A1HG MT DTT DM8A1HG MA Inhibitor DM8A1HG RN Discovery of novel sphingosine kinase 1 inhibitors. Bioorg Med Chem Lett. 2009 Nov 1;19(21):6119-21. DM8A1HG RU https://pubmed.ncbi.nlm.nih.gov/19800228 DM96XYI DI DM96XYI DM96XYI DN (S)-2-Amino-4-methyl-pentane-1-thiol DM96XYI MI TTPHMWB DM96XYI MN Aminopeptidase N (ANPEP) DM96XYI MT DTT DM96XYI MA Inhibitor DM96XYI RN Design of the first highly potent and selective aminopeptidase N (EC 3.4.11.2) inhibitor. Bioorg Med Chem Lett. 1999 Jun 7;9(11):1511-6. DM96XYI RU https://pubmed.ncbi.nlm.nih.gov/10386926 DMOVQ1T DI DMOVQ1T DMOVQ1T DN (S)-2-Amino-4-methylsulfanyl-butane-1-thiol DMOVQ1T MI TTPHMWB DMOVQ1T MN Aminopeptidase N (ANPEP) DMOVQ1T MT DTT DMOVQ1T MA Inhibitor DMOVQ1T RN Design of the first highly potent and selective aminopeptidase N (EC 3.4.11.2) inhibitor. Bioorg Med Chem Lett. 1999 Jun 7;9(11):1511-6. DMOVQ1T RU https://pubmed.ncbi.nlm.nih.gov/10386926 DMJEGMI DI DMJEGMI DMJEGMI DN (S)-2-Amino-4-phenyl-butane-1-thiol DMJEGMI MI TTPHMWB DMJEGMI MN Aminopeptidase N (ANPEP) DMJEGMI MT DTT DMJEGMI MA Inhibitor DMJEGMI RN Design of the first highly potent and selective aminopeptidase N (EC 3.4.11.2) inhibitor. Bioorg Med Chem Lett. 1999 Jun 7;9(11):1511-6. DMJEGMI RU https://pubmed.ncbi.nlm.nih.gov/10386926 DMZSWDM DI DMZSWDM DMZSWDM DN (S)-2-Amino-5-(N-methyl-guanidino)-pentanoic acid DMZSWDM MI TTZUFI5 DMZSWDM MN Nitric-oxide synthase brain (NOS1) DMZSWDM MT DTT DMZSWDM MA Inhibitor DMZSWDM RN 2-Iminopiperidine and other 2-iminoazaheterocycles as potent inhibitors of human nitric oxide synthase isoforms. J Med Chem. 1996 Feb 2;39(3):669-72. DMZSWDM RU https://pubmed.ncbi.nlm.nih.gov/8576908 DMZSWDM DI DMZSWDM DMZSWDM DN (S)-2-Amino-5-(N-methyl-guanidino)-pentanoic acid DMZSWDM MI TTCM4B3 DMZSWDM MN Nitric-oxide synthase endothelial (NOS3) DMZSWDM MT DTT DMZSWDM MA Inhibitor DMZSWDM RN 2-Iminopiperidine and other 2-iminoazaheterocycles as potent inhibitors of human nitric oxide synthase isoforms. J Med Chem. 1996 Feb 2;39(3):669-72. DMZSWDM RU https://pubmed.ncbi.nlm.nih.gov/8576908 DMZSWDM DI DMZSWDM DMZSWDM DN (S)-2-Amino-5-(N-methyl-guanidino)-pentanoic acid DMZSWDM MI TTF10I9 DMZSWDM MN Nitric-oxide synthase inducible (NOS2) DMZSWDM MT DTT DMZSWDM MA Inhibitor DMZSWDM RN 2-Iminopiperidine and other 2-iminoazaheterocycles as potent inhibitors of human nitric oxide synthase isoforms. J Med Chem. 1996 Feb 2;39(3):669-72. DMZSWDM RU https://pubmed.ncbi.nlm.nih.gov/8576908 DMRG80O DI DMRG80O DMRG80O DN (S)-2-Amino-6-[(E)-ethylimino]-hexanoic acid DMRG80O MI TTF10I9 DMRG80O MN Nitric-oxide synthase inducible (NOS2) DMRG80O MT DTT DMRG80O MA Inhibitor DMRG80O RN 2-Iminopiperidine and other 2-iminoazaheterocycles as potent inhibitors of human nitric oxide synthase isoforms. J Med Chem. 1996 Feb 2;39(3):669-72. DMRG80O RU https://pubmed.ncbi.nlm.nih.gov/8576908 DMG0CSZ DI DMG0CSZ DMG0CSZ DN (S)-2-amino-6-hydroxy-N-(4-octylphenyl)hexanamide DMG0CSZ MI TTCN0M9 DMG0CSZ MN Sphingosine kinase 2 (SPHK2) DMG0CSZ MT DTT DMG0CSZ MA Inhibitor DMG0CSZ RN Discovery of novel sphingosine kinase 1 inhibitors. Bioorg Med Chem Lett. 2009 Nov 1;19(21):6119-21. DMG0CSZ RU https://pubmed.ncbi.nlm.nih.gov/19800228 DMN1G8L DI DMN1G8L DMN1G8L DN (S)-2-amino-N-(1-cyano-2-phenylethyl)acetamide DMN1G8L MI TT4H0V2 DMN1G8L MN Dipeptidyl peptidase I (CTSC) DMN1G8L MT DTT DMN1G8L MA Inhibitor DMN1G8L RN Dipeptidyl nitriles as human dipeptidyl peptidase I inhibitors. Bioorg Med Chem Lett. 2006 Jul 1;16(13):3614-7. DMN1G8L RU https://pubmed.ncbi.nlm.nih.gov/16647256 DMDWFHV DI DMDWFHV DMDWFHV DN (S)-2-Amino-N-cyclopentyl-7-mercaptoheptanamide DMDWFHV MI TT5ZKDI DMDWFHV MN Histone deacetylase 6 (HDAC6) DMDWFHV MT DTT DMDWFHV MA Inhibitor DMDWFHV RN Design, synthesis, structure--selectivity relationship, and effect on human cancer cells of a novel series of histone deacetylase 6-selective inhib... J Med Chem. 2007 Nov 1;50(22):5425-38. DMDWFHV RU https://pubmed.ncbi.nlm.nih.gov/17929798 DMYG8EV DI DMYG8EV DMYG8EV DN (S)-2-Amino-propane-1-thiol DMYG8EV MI TTPHMWB DMYG8EV MN Aminopeptidase N (ANPEP) DMYG8EV MT DTT DMYG8EV MA Inhibitor DMYG8EV RN Design of the first highly potent and selective aminopeptidase N (EC 3.4.11.2) inhibitor. Bioorg Med Chem Lett. 1999 Jun 7;9(11):1511-6. DMYG8EV RU https://pubmed.ncbi.nlm.nih.gov/10386926 DMQGCM3 DI DMQGCM3 DMQGCM3 DN (S)-2-methyl-1-(2-m-tolyl-ethyl)-pyrrolidine DMQGCM3 MI TT9JNIC DMQGCM3 MN Histamine H3 receptor (H3R) DMQGCM3 MT DTT DMQGCM3 MA Inhibitor DMQGCM3 RN In vitro SAR of pyrrolidine-containing histamine H3 receptor antagonists: trends across multiple chemical series. Bioorg Med Chem Lett. 2008 Jan 1;18(1):355-9. DMQGCM3 RU https://pubmed.ncbi.nlm.nih.gov/18077160 DMJFI75 DI DMJFI75 DMJFI75 DN (S)-2-methyl-1-(2-p-tolyl-ethyl)-pyrrolidine DMJFI75 MI TT9JNIC DMJFI75 MN Histamine H3 receptor (H3R) DMJFI75 MT DTT DMJFI75 MA Inhibitor DMJFI75 RN In vitro SAR of pyrrolidine-containing histamine H3 receptor antagonists: trends across multiple chemical series. Bioorg Med Chem Lett. 2008 Jan 1;18(1):355-9. DMJFI75 RU https://pubmed.ncbi.nlm.nih.gov/18077160 DMS5IHX DI DMS5IHX DMS5IHX DN (S)-3-(1'-Adamantanecarbonyl)amino-caprolactam DMS5IHX MI TTFZYTO DMS5IHX MN C-C chemokine receptor type 2 (CCR2) DMS5IHX MT DTT DMS5IHX MA Inhibitor DMS5IHX RN Highly potent, orally available anti-inflammatory broad-spectrum chemokine inhibitors. J Med Chem. 2009 Jun 11;52(11):3591-5. DMS5IHX RU https://pubmed.ncbi.nlm.nih.gov/19425597 DM435QN DI DM435QN DM435QN DN (S)-3-(1H-imidazol-4-yl)propyl sec-butylcarbamate DM435QN MI TT9JNIC DM435QN MN Histamine H3 receptor (H3R) DM435QN MT DTT DM435QN MA Inhibitor DM435QN RN Histamine H3 and H4 receptor affinity of branched 3-(1H-imidazol-4-yl)propyl N-alkylcarbamates. Bioorg Med Chem Lett. 2009 Dec 1;19(23):6682-5. DM435QN RU https://pubmed.ncbi.nlm.nih.gov/19846299 DMANICH DI DMANICH DMANICH DN (S)-3-(2',2'-Dimethyl-propionyl)amino-caprolactam DMANICH MI TTFZYTO DMANICH MN C-C chemokine receptor type 2 (CCR2) DMANICH MT DTT DMANICH MA Inhibitor DMANICH RN Highly potent, orally available anti-inflammatory broad-spectrum chemokine inhibitors. J Med Chem. 2009 Jun 11;52(11):3591-5. DMANICH RU https://pubmed.ncbi.nlm.nih.gov/19425597 DMTBG57 DI DMTBG57 DMTBG57 DN (S)-3-(aminomethyl)-4-(furan-2-yl)butanoic acid DMTBG57 MI TTFK1JQ DMTBG57 MN Voltage-gated calcium channel alpha-2/delta-1 (CACNA2D1) DMTBG57 MT DTT DMTBG57 MA Inhibitor DMTBG57 RN Heteroaromatic side-chain analogs of pregabalin. Bioorg Med Chem Lett. 2006 May 1;16(9):2329-32. DMTBG57 RU https://pubmed.ncbi.nlm.nih.gov/16099652 DMB9CQL DI DMB9CQL DMB9CQL DN (S)-3-(azetidin-2-ylmethoxy)-2-fluoropyridine DMB9CQL MI TTF4E0J DMB9CQL MN Neuronal acetylcholine receptor alpha-2 (CHRNA2) DMB9CQL MT DTT DMB9CQL MA Inhibitor DMB9CQL RN Synthesis and biological evaluation of novel carbon-11 labeled pyridyl ethers: candidate ligands for in vivo imaging of alpha4beta2 nicotinic acety... Bioorg Med Chem. 2009 Jul 1;17(13):4367-77. DMB9CQL RU https://pubmed.ncbi.nlm.nih.gov/19481945 DM5ILK1 DI DM5ILK1 DM5ILK1 DN (S)-3-(naphthalen-2-ylmethoxy)pyrrolidine DM5ILK1 MI TTVBI8W DM5ILK1 MN Dopamine transporter (DAT) DM5ILK1 MT DTT DM5ILK1 MA Inhibitor DM5ILK1 RN Design and optimization of selective serotonin re-uptake inhibitors with high synthetic accessibility. Part 1. Bioorg Med Chem Lett. 2009 Apr 15;19(8):2329-32. DM5ILK1 RU https://pubmed.ncbi.nlm.nih.gov/19282174 DM5ILK1 DI DM5ILK1 DM5ILK1 DN (S)-3-(naphthalen-2-ylmethoxy)pyrrolidine DM5ILK1 MI TTAWNKZ DM5ILK1 MN Norepinephrine transporter (NET) DM5ILK1 MT DTT DM5ILK1 MA Inhibitor DM5ILK1 RN Design and optimization of selective serotonin re-uptake inhibitors with high synthetic accessibility. Part 1. Bioorg Med Chem Lett. 2009 Apr 15;19(8):2329-32. DM5ILK1 RU https://pubmed.ncbi.nlm.nih.gov/19282174 DM5ILK1 DI DM5ILK1 DM5ILK1 DN (S)-3-(naphthalen-2-ylmethoxy)pyrrolidine DM5ILK1 MI TT3ROYC DM5ILK1 MN Serotonin transporter (SERT) DM5ILK1 MT DTT DM5ILK1 MA Inhibitor DM5ILK1 RN Design and optimization of selective serotonin re-uptake inhibitors with high synthetic accessibility. Part 1. Bioorg Med Chem Lett. 2009 Apr 15;19(8):2329-32. DM5ILK1 RU https://pubmed.ncbi.nlm.nih.gov/19282174 DM5ILK1 DI DM5ILK1 DM5ILK1 DN (S)-3-(naphthalen-2-ylmethoxy)pyrrolidine DM5ILK1 MI TTQ6VDM DM5ILK1 MN Voltage-gated potassium channel Kv11.1 (KCNH2) DM5ILK1 MT DTT DM5ILK1 MA Inhibitor DM5ILK1 RN Design and optimization of selective serotonin re-uptake inhibitors with high synthetic accessibility. Part 1. Bioorg Med Chem Lett. 2009 Apr 15;19(8):2329-32. DM5ILK1 RU https://pubmed.ncbi.nlm.nih.gov/19282174 DMG5BUA DI DMG5BUA DMG5BUA DN (S)-3,4-DCPG DMG5BUA MI TTICZ1O DMG5BUA MN Metabotropic glutamate receptor 4 (mGluR4) DMG5BUA MT DTT DMG5BUA MA Agonist DMG5BUA RN (S)-3,4-DCPG, a potent and selective mGlu8a receptor agonist, activates metabotropic glutamate receptors on primary afferent terminals in the neonatal rat spinal cord. Neuropharmacology. 2001 Mar;40(3):311-8. DMG5BUA RU https://pubmed.ncbi.nlm.nih.gov/11166323 DMG5BUA DI DMG5BUA DMG5BUA DN (S)-3,4-DCPG DMG5BUA MI TTWRP2F DMG5BUA MN Metabotropic glutamate receptor 6 (mGluR6) DMG5BUA MT DTT DMG5BUA MA Agonist DMG5BUA RN (S)-3,4-DCPG, a potent and selective mGlu8a receptor agonist, activates metabotropic glutamate receptors on primary afferent terminals in the neonatal rat spinal cord. Neuropharmacology. 2001 Mar;40(3):311-8. DMG5BUA RU https://pubmed.ncbi.nlm.nih.gov/11166323 DMG5BUA DI DMG5BUA DMG5BUA DN (S)-3,4-DCPG DMG5BUA MI TT0IFKL DMG5BUA MN Metabotropic glutamate receptor 8 (mGluR8) DMG5BUA MT DTT DMG5BUA MA Agonist DMG5BUA RN (S)-3,4-DCPG, a potent and selective mGlu8a receptor agonist, activates metabotropic glutamate receptors on primary afferent terminals in the neonatal rat spinal cord. Neuropharmacology. 2001 Mar;40(3):311-8. DMG5BUA RU https://pubmed.ncbi.nlm.nih.gov/11166323 DMQ0FVJ DI DMQ0FVJ DMQ0FVJ DN (S)-3HPG DMQ0FVJ MI TTVBPDM DMQ0FVJ MN Metabotropic glutamate receptor 1 (mGluR1) DMQ0FVJ MT DTT DMQ0FVJ MA Agonist DMQ0FVJ RN Characterization of [(3)H]Quisqualate binding to recombinant rat metabotropic glutamate 1a and 5a receptors and to rat and human brain sections. J Neurochem. 2000 Dec;75(6):2590-601. DMQ0FVJ RU https://pubmed.ncbi.nlm.nih.gov/11080213 DMQ0FVJ DI DMQ0FVJ DMQ0FVJ DN (S)-3HPG DMQ0FVJ MI TTHS256 DMQ0FVJ MN Metabotropic glutamate receptor 5 (mGluR5) DMQ0FVJ MT DTT DMQ0FVJ MA Agonist DMQ0FVJ RN Characterization of [(3)H]Quisqualate binding to recombinant rat metabotropic glutamate 1a and 5a receptors and to rat and human brain sections. J Neurochem. 2000 Dec;75(6):2590-601. DMQ0FVJ RU https://pubmed.ncbi.nlm.nih.gov/11080213 DM3TW9V DI DM3TW9V DM3TW9V DN (S)-3-hydroxy-3-methylglutaryl-CoA DM3TW9V MI TTQF4TK DM3TW9V MN Hydroxymethylglutaryl-CoA synthase 1 (HMGCS1) DM3TW9V MT DTT DM3TW9V MA Inhibitor DM3TW9V RN A visible wavelength spectrophotometric assay suitable for high-throughput screening of 3-hydroxy-3-methylglutaryl-CoA synthase. Anal Biochem. 2010 Jan 1;396(1):96-102. DM3TW9V RU https://pubmed.ncbi.nlm.nih.gov/19706283 DMS4JAG DI DMS4JAG DMS4JAG DN (S)-3-Methyl-1,2,3,4-tetrahydro-isoquinoline DMS4JAG MI TTWG9A4 DMS4JAG MN Adrenergic receptor alpha-2A (ADRA2A) DMS4JAG MT DTT DMS4JAG MA Inhibitor DMS4JAG RN Effect of ring size or an additional heteroatom on the potency and selectivity of bicyclic benzylamine-type inhibitors of phenylethanolamine N-meth... J Med Chem. 1996 Aug 30;39(18):3539-46. DMS4JAG RU https://pubmed.ncbi.nlm.nih.gov/8784452 DMS4JAG DI DMS4JAG DMS4JAG DN (S)-3-Methyl-1,2,3,4-tetrahydro-isoquinoline DMS4JAG MI TTWM4TY DMS4JAG MN Adrenergic receptor alpha-2B (ADRA2B) DMS4JAG MT DTT DMS4JAG MA Inhibitor DMS4JAG RN Effect of ring size or an additional heteroatom on the potency and selectivity of bicyclic benzylamine-type inhibitors of phenylethanolamine N-meth... J Med Chem. 1996 Aug 30;39(18):3539-46. DMS4JAG RU https://pubmed.ncbi.nlm.nih.gov/8784452 DMS4JAG DI DMS4JAG DMS4JAG DN (S)-3-Methyl-1,2,3,4-tetrahydro-isoquinoline DMS4JAG MI TT2NUT5 DMS4JAG MN Adrenergic receptor alpha-2C (ADRA2C) DMS4JAG MT DTT DMS4JAG MA Inhibitor DMS4JAG RN Effect of ring size or an additional heteroatom on the potency and selectivity of bicyclic benzylamine-type inhibitors of phenylethanolamine N-meth... J Med Chem. 1996 Aug 30;39(18):3539-46. DMS4JAG RU https://pubmed.ncbi.nlm.nih.gov/8784452 DMIG9H3 DI DMIG9H3 DMIG9H3 DN (S)-3-Propyl-[1,4]thiazepan-(5E)-ylideneamine DMIG9H3 MI TTZUFI5 DMIG9H3 MN Nitric-oxide synthase brain (NOS1) DMIG9H3 MT DTT DMIG9H3 MA Inhibitor DMIG9H3 RN Synthesis of analogs of (1,4)-3- and 5-imino oxazepane, thiazepane, and diazepane as inhibitors of nitric oxide synthases. Bioorg Med Chem Lett. 2004 Dec 6;14(23):5907-11. DMIG9H3 RU https://pubmed.ncbi.nlm.nih.gov/15501067 DMIG9H3 DI DMIG9H3 DMIG9H3 DN (S)-3-Propyl-[1,4]thiazepan-(5E)-ylideneamine DMIG9H3 MI TTCM4B3 DMIG9H3 MN Nitric-oxide synthase endothelial (NOS3) DMIG9H3 MT DTT DMIG9H3 MA Inhibitor DMIG9H3 RN Synthesis of analogs of (1,4)-3- and 5-imino oxazepane, thiazepane, and diazepane as inhibitors of nitric oxide synthases. Bioorg Med Chem Lett. 2004 Dec 6;14(23):5907-11. DMIG9H3 RU https://pubmed.ncbi.nlm.nih.gov/15501067 DMIG9H3 DI DMIG9H3 DMIG9H3 DN (S)-3-Propyl-[1,4]thiazepan-(5E)-ylideneamine DMIG9H3 MI TTF10I9 DMIG9H3 MN Nitric-oxide synthase inducible (NOS2) DMIG9H3 MT DTT DMIG9H3 MA Inhibitor DMIG9H3 RN Synthesis of analogs of (1,4)-3- and 5-imino oxazepane, thiazepane, and diazepane as inhibitors of nitric oxide synthases. Bioorg Med Chem Lett. 2004 Dec 6;14(23):5907-11. DMIG9H3 RU https://pubmed.ncbi.nlm.nih.gov/15501067 DMLZBJT DI DMLZBJT DMLZBJT DN (S)-4-(2-(2-methylpyrrolidin-1-yl)ethyl)pyridine DMLZBJT MI TT9JNIC DMLZBJT MN Histamine H3 receptor (H3R) DMLZBJT MT DTT DMLZBJT MA Inhibitor DMLZBJT RN In vitro SAR of pyrrolidine-containing histamine H3 receptor antagonists: trends across multiple chemical series. Bioorg Med Chem Lett. 2008 Jan 1;18(1):355-9. DMLZBJT RU https://pubmed.ncbi.nlm.nih.gov/18077160 DMN9YXL DI DMN9YXL DMN9YXL DN (S)-4-AHCP DMN9YXL MI TT0MYE2 DMN9YXL MN Glutamate receptor ionotropic kainate 1 (GRIK1) DMN9YXL MT DTT DMN9YXL MA Agonist DMN9YXL RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 450). DMN9YXL RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=450 DMQK4I2 DI DMQK4I2 DMQK4I2 DN (S)-4C3HPG DMQK4I2 MI TTVBPDM DMQK4I2 MN Metabotropic glutamate receptor 1 (mGluR1) DMQK4I2 MT DTT DMQK4I2 MA Antagonist DMQK4I2 RN Characterization of [(3)H]Quisqualate binding to recombinant rat metabotropic glutamate 1a and 5a receptors and to rat and human brain sections. J Neurochem. 2000 Dec;75(6):2590-601. DMQK4I2 RU https://pubmed.ncbi.nlm.nih.gov/11080213 DMQK4I2 DI DMQK4I2 DMQK4I2 DN (S)-4C3HPG DMQK4I2 MI TTXJ47W DMQK4I2 MN Metabotropic glutamate receptor 2 (mGluR2) DMQK4I2 MT DTT DMQK4I2 MA Agonist DMQK4I2 RN Characterization of [3H]-(2S,2'R,3'R)-2-(2',3'-dicarboxy-cyclopropyl)glycine ([3H]-DCG IV) binding to metabotropic mGlu2 receptor-transfected cell membranes. Br J Pharmacol. 1998 Feb;123(3):497-504. DMQK4I2 RU https://pubmed.ncbi.nlm.nih.gov/9504391 DMQK4I2 DI DMQK4I2 DMQK4I2 DN (S)-4C3HPG DMQK4I2 MI TTHS256 DMQK4I2 MN Metabotropic glutamate receptor 5 (mGluR5) DMQK4I2 MT DTT DMQK4I2 MA Antagonist DMQK4I2 RN Characterization of [(3)H]Quisqualate binding to recombinant rat metabotropic glutamate 1a and 5a receptors and to rat and human brain sections. J Neurochem. 2000 Dec;75(6):2590-601. DMQK4I2 RU https://pubmed.ncbi.nlm.nih.gov/11080213 DMI12X9 DI DMI12X9 DMI12X9 DN (S)-4-CMTB DMI12X9 MI TT0FYAN DMI12X9 MN Free fatty acid receptor 2 (FFAR2) DMI12X9 MT DTT DMI12X9 MA Agonist DMI12X9 RN Extracellular ionic locks determine variation in constitutive activity and ligand potency between species orthologs of the free fatty acid receptors FFA2 and FFA3. J Biol Chem. 2012 Nov 30;287(49):41195-209. DMI12X9 RU https://pubmed.ncbi.nlm.nih.gov/23066016 DMI12X9 DI DMI12X9 DMI12X9 DN (S)-4-CMTB DMI12X9 MI TTXDOHN DMI12X9 MN Free fatty acid receptor 3 (FFAR3) DMI12X9 MT DTT DMI12X9 MA Agonist DMI12X9 RN Identification and functional characterization of allosteric agonists for the G protein-coupled receptor FFA2. Mol Pharmacol. 2008 Dec;74(6):1599-609. DMI12X9 RU https://pubmed.ncbi.nlm.nih.gov/18818303 DMZ9UIL DI DMZ9UIL DMZ9UIL DN (S)-4CPG DMZ9UIL MI TTVBPDM DMZ9UIL MN Metabotropic glutamate receptor 1 (mGluR1) DMZ9UIL MT DTT DMZ9UIL MA Antagonist DMZ9UIL RN [3H]R214127: a novel high-affinity radioligand for the mGlu1 receptor reveals a common binding site shared by multiple allosteric antagonists. Mol Pharmacol. 2003 May;63(5):1082-93. DMZ9UIL RU https://pubmed.ncbi.nlm.nih.gov/12695537 DMZ9UIL DI DMZ9UIL DMZ9UIL DN (S)-4CPG DMZ9UIL MI TTHS256 DMZ9UIL MN Metabotropic glutamate receptor 5 (mGluR5) DMZ9UIL MT DTT DMZ9UIL MA Antagonist DMZ9UIL RN Characterization of [(3)H]Quisqualate binding to recombinant rat metabotropic glutamate 1a and 5a receptors and to rat and human brain sections. J Neurochem. 2000 Dec;75(6):2590-601. DMZ9UIL RU https://pubmed.ncbi.nlm.nih.gov/11080213 DMCIZ7P DI DMCIZ7P DMCIZ7P DN (S)-5-fluorowillardiine DMCIZ7P MI TTVPQTF DMCIZ7P MN Glutamate receptor AMPA 1 (GRIA1) DMCIZ7P MT DTT DMCIZ7P MA Agonist DMCIZ7P RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 444). DMCIZ7P RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=444 DMCIZ7P DI DMCIZ7P DMCIZ7P DN (S)-5-fluorowillardiine DMCIZ7P MI TT9HLZ0 DMCIZ7P MN Glutamate receptor AMPA 2 (GRIA2) DMCIZ7P MT DTT DMCIZ7P MA Agonist DMCIZ7P RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 445). DMCIZ7P RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=445 DMCIZ7P DI DMCIZ7P DMCIZ7P DN (S)-5-fluorowillardiine DMCIZ7P MI TT82EZV DMCIZ7P MN Glutamate receptor AMPA 3 (GRIA3) DMCIZ7P MT DTT DMCIZ7P MA Agonist DMCIZ7P RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 446). DMCIZ7P RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=446 DMCIZ7P DI DMCIZ7P DMCIZ7P DN (S)-5-fluorowillardiine DMCIZ7P MI TTPJR0G DMCIZ7P MN Glutamate receptor AMPA 4 (GRIA4) DMCIZ7P MT DTT DMCIZ7P MA Agonist DMCIZ7P RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 447). DMCIZ7P RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=447 DM1DNRP DI DM1DNRP DM1DNRP DN (S)-5-iodowillardiine DM1DNRP MI TT0MYE2 DM1DNRP MN Glutamate receptor ionotropic kainate 1 (GRIK1) DM1DNRP MT DTT DM1DNRP MA Agonist DM1DNRP RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 450). DM1DNRP RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=450 DM32PJ5 DI DM32PJ5 DM32PJ5 DN (S)-6-(pyrrolidin-3-ylmethoxy)-2-naphthonitrile DM32PJ5 MI TTAWNKZ DM32PJ5 MN Norepinephrine transporter (NET) DM32PJ5 MT DTT DM32PJ5 MA Inhibitor DM32PJ5 RN Design and optimization of selective serotonin re-uptake inhibitors with high synthetic accessibility. Part 1. Bioorg Med Chem Lett. 2009 Apr 15;19(8):2329-32. DM32PJ5 RU https://pubmed.ncbi.nlm.nih.gov/19282174 DM32PJ5 DI DM32PJ5 DM32PJ5 DN (S)-6-(pyrrolidin-3-ylmethoxy)-2-naphthonitrile DM32PJ5 MI TT3ROYC DM32PJ5 MN Serotonin transporter (SERT) DM32PJ5 MT DTT DM32PJ5 MA Inhibitor DM32PJ5 RN Design and optimization of selective serotonin re-uptake inhibitors with high synthetic accessibility. Part 1. Bioorg Med Chem Lett. 2009 Apr 15;19(8):2329-32. DM32PJ5 RU https://pubmed.ncbi.nlm.nih.gov/19282174 DMG58HM DI DMG58HM DMG58HM DN (S)-6-Amino-2-(2-imino-ethylamino)-hexanoic acid DMG58HM MI TTZUFI5 DMG58HM MN Nitric-oxide synthase brain (NOS1) DMG58HM MT DTT DMG58HM MA Inhibitor DMG58HM RN Synthesis of analogs of (1,4)-3- and 5-imino oxazepane, thiazepane, and diazepane as inhibitors of nitric oxide synthases. Bioorg Med Chem Lett. 2004 Dec 6;14(23):5907-11. DMG58HM RU https://pubmed.ncbi.nlm.nih.gov/15501067 DMG58HM DI DMG58HM DMG58HM DN (S)-6-Amino-2-(2-imino-ethylamino)-hexanoic acid DMG58HM MI TTCM4B3 DMG58HM MN Nitric-oxide synthase endothelial (NOS3) DMG58HM MT DTT DMG58HM MA Inhibitor DMG58HM RN Synthesis of analogs of (1,4)-3- and 5-imino oxazepane, thiazepane, and diazepane as inhibitors of nitric oxide synthases. Bioorg Med Chem Lett. 2004 Dec 6;14(23):5907-11. DMG58HM RU https://pubmed.ncbi.nlm.nih.gov/15501067 DMG58HM DI DMG58HM DMG58HM DN (S)-6-Amino-2-(2-imino-ethylamino)-hexanoic acid DMG58HM MI TTF10I9 DMG58HM MN Nitric-oxide synthase inducible (NOS2) DMG58HM MT DTT DMG58HM MA Inhibitor DMG58HM RN Synthesis of analogs of (1,4)-3- and 5-imino oxazepane, thiazepane, and diazepane as inhibitors of nitric oxide synthases. Bioorg Med Chem Lett. 2004 Dec 6;14(23):5907-11. DMG58HM RU https://pubmed.ncbi.nlm.nih.gov/15501067 DMTUZIN DI DMTUZIN DMTUZIN DN (S)-alpha-methylhistamine DMTUZIN MI TT9JNIC DMTUZIN MN Histamine H3 receptor (H3R) DMTUZIN MT DTT DMTUZIN MA Agonist DMTUZIN RN Characteristics of recombinantly expressed rat and human histamine H3 receptors. Eur J Pharmacol. 2002 Oct 18;453(1):33-41. DMTUZIN RU https://pubmed.ncbi.nlm.nih.gov/12393057 DMTUZIN DI DMTUZIN DMTUZIN DN (S)-alpha-methylhistamine DMTUZIN MI TTXJ178 DMTUZIN MN Histamine H4 receptor (H4R) DMTUZIN MT DTT DMTUZIN MA Agonist DMTUZIN RN Cloning and characterization of a novel human histamine receptor. J Pharmacol Exp Ther. 2001 Mar;296(3):1058-66. DMTUZIN RU https://pubmed.ncbi.nlm.nih.gov/11181941 DMNJSTM DI DMNJSTM DMNJSTM DN (S)-AMPA DMNJSTM MI TTAN6JD DMNJSTM MN Glutamate receptor AMPA (GRIA) DMNJSTM MT DTT DMNJSTM MA Inhibitor DMNJSTM RN Synthesis and pharmacology of willardiine derivatives acting as antagonists of kainate receptors. J Med Chem. 2005 Dec 1;48(24):7867-81. DMNJSTM RU https://pubmed.ncbi.nlm.nih.gov/16302825 DMNJSTM DI DMNJSTM DMNJSTM DN (S)-AMPA DMNJSTM MI TTVPQTF DMNJSTM MN Glutamate receptor AMPA 1 (GRIA1) DMNJSTM MT DTT DMNJSTM MA Inhibitor DMNJSTM RN Synthesis and pharmacology of willardiine derivatives acting as antagonists of kainate receptors. J Med Chem. 2005 Dec 1;48(24):7867-81. DMNJSTM RU https://pubmed.ncbi.nlm.nih.gov/16302825 DMEKGIX DI DMEKGIX DMEKGIX DN (S)APOMORPHINE DMEKGIX MI TTZFYLI DMEKGIX MN Dopamine D1 receptor (D1R) DMEKGIX MT DTT DMEKGIX MA Inhibitor DMEKGIX RN Synthesis and dopamine receptor affinities of enantiomers of 2-substituted apomorphines and their N-n-propyl analogues. J Med Chem. 1990 Jun;33(6):1800-5. DMEKGIX RU https://pubmed.ncbi.nlm.nih.gov/1971309 DMEKGIX DI DMEKGIX DMEKGIX DN (S)APOMORPHINE DMEKGIX MI TTEX248 DMEKGIX MN Dopamine D2 receptor (D2R) DMEKGIX MT DTT DMEKGIX MA Inhibitor DMEKGIX RN Synthesis and dopamine receptor affinities of enantiomers of 2-substituted apomorphines and their N-n-propyl analogues. J Med Chem. 1990 Jun;33(6):1800-5. DMEKGIX RU https://pubmed.ncbi.nlm.nih.gov/1971309 DMA43NY DI DMA43NY DMA43NY DN (S)-benzyl 4-chloro-3-oxobutan-2-ylcarbamate DMA43NY MI TTGKNB4 DMA43NY MN Epidermal growth factor receptor (EGFR) DMA43NY MT DTT DMA43NY MA Inhibitor DMA43NY RN Protein-tyrosine kinase inhibition: mechanism-based discovery of antitumor agents. J Nat Prod. 1992 Nov;55(11):1529-60. DMA43NY RU https://pubmed.ncbi.nlm.nih.gov/1479375 DMPI0AX DI DMPI0AX DMPI0AX DN (S)-BULBOCAPNINE DMPI0AX MI TTZFYLI DMPI0AX MN Dopamine D1 receptor (D1R) DMPI0AX MT DTT DMPI0AX MA Inhibitor DMPI0AX RN Advances in development of dopaminergic aporphinoids. J Med Chem. 2007 Jan 25;50(2):171-81. DMPI0AX RU https://pubmed.ncbi.nlm.nih.gov/17228858 DMPI0AX DI DMPI0AX DMPI0AX DN (S)-BULBOCAPNINE DMPI0AX MI TTEX248 DMPI0AX MN Dopamine D2 receptor (D2R) DMPI0AX MT DTT DMPI0AX MA Inhibitor DMPI0AX RN Advances in development of dopaminergic aporphinoids. J Med Chem. 2007 Jan 25;50(2):171-81. DMPI0AX RU https://pubmed.ncbi.nlm.nih.gov/17228858 DMJN659 DI DMJN659 DMJN659 DN (S)-cetirizine DMJN659 MI TTTIBOJ DMJN659 MN Histamine H1 receptor (H1R) DMJN659 MT DTT DMJN659 MA Antagonist DMJN659 RN Large-scale overproduction, functional purification and ligand affinities of the His-tagged human histamine H1 receptor. Eur J Biochem. 2004 Jul;271(13):2636-46. DMJN659 RU https://pubmed.ncbi.nlm.nih.gov/15206929 DMQSC21 DI DMQSC21 DMQSC21 DN (S)-DHPA DMQSC21 MI TTM2AOE DMQSC21 MN Adenosine A2a receptor (ADORA2A) DMQSC21 MT DTT DMQSC21 MA Inhibitor DMQSC21 RN 8-Bromo-9-alkyl adenine derivatives as tools for developing new adenosine A2A and A2B receptors ligands. Bioorg Med Chem. 2009 Apr 1;17(7):2812-22. DMQSC21 RU https://pubmed.ncbi.nlm.nih.gov/19282184 DM0SEYN DI DM0SEYN DM0SEYN DN (S)-dimethylenastron DM0SEYN MI TTBGTCW DM0SEYN MN Kinesin spindle messenger RNA (KIF11 mRNA) DM0SEYN MT DTT DM0SEYN MA Inhibitor DM0SEYN RN Structural basis for inhibition of Eg5 by dihydropyrimidines: stereoselectivity of antimitotic inhibitors enastron, dimethylenastron and fluorastrol. J Med Chem. 2010 Aug 12;53(15):5676-83. DM0SEYN RU https://pubmed.ncbi.nlm.nih.gov/20597485 DM0EQTM DI DM0EQTM DM0EQTM DN (S)-EF-1520 DM0EQTM MI TTPRKM0 DM0EQTM MN GABA transporter GAT-1 (SLC6A1) DM0EQTM MT DTT DM0EQTM MA Inhibitor DM0EQTM RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 929). DM0EQTM RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=929 DM0EQTM DI DM0EQTM DM0EQTM DN (S)-EF-1520 DM0EQTM MI TTQBMPI DM0EQTM MN Na(+)/Cl(-) betaine/GABA transporter (SLC6A12) DM0EQTM MT DTT DM0EQTM MA Inhibitor DM0EQTM RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 932). DM0EQTM RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=932 DMWNEA1 DI DMWNEA1 DMWNEA1 DN (S)-enastron DMWNEA1 MI TTBGTCW DMWNEA1 MN Kinesin spindle messenger RNA (KIF11 mRNA) DMWNEA1 MT DTT DMWNEA1 MA Inhibitor DMWNEA1 RN Structural basis for inhibition of Eg5 by dihydropyrimidines: stereoselectivity of antimitotic inhibitors enastron, dimethylenastron and fluorastrol. J Med Chem. 2010 Aug 12;53(15):5676-83. DMWNEA1 RU https://pubmed.ncbi.nlm.nih.gov/20597485 DMFSXTJ DI DMFSXTJ DMFSXTJ DN (S)-Ethyl 6-(2-oxohexadecanamido)decanoate DMFSXTJ MI TTT1JVS DMFSXTJ MN Cytosolic phospholipase A2 (GIVA cPLA2) DMFSXTJ MT DTT DMFSXTJ MA Inhibitor DMFSXTJ RN Structure-activity relationships of natural and non-natural amino acid-based amide and 2-oxoamide inhibitors of human phospholipase A(2) enzymes. Bioorg Med Chem. 2008 Dec 15;16(24):10257-69. DMFSXTJ RU https://pubmed.ncbi.nlm.nih.gov/18993078 DM715AS DI DM715AS DM715AS DN (S)-flurocarazolol DM715AS MI TTSQIFT DM715AS MN 5-HT 1A receptor (HTR1A) DM715AS MT DTT DM715AS MA Antagonist DM715AS RN The in vitro pharmacology of the beta-adrenergic receptor pet ligand (s)-fluorocarazolol reveals high affinity for cloned beta-adrenergic receptors and moderate affinity for the human 5-HT1A receptor. Psychopharmacology (Berl). 2001 Aug;157(1):111-4. DM715AS RU https://pubmed.ncbi.nlm.nih.gov/11512051 DM715AS DI DM715AS DM715AS DN (S)-flurocarazolol DM715AS MI TTK8CXU DM715AS MN 5-HT 1B receptor (HTR1B) DM715AS MT DTT DM715AS MA Antagonist DM715AS RN The in vitro pharmacology of the beta-adrenergic receptor pet ligand (s)-fluorocarazolol reveals high affinity for cloned beta-adrenergic receptors and moderate affinity for the human 5-HT1A receptor. Psychopharmacology (Berl). 2001 Aug;157(1):111-4. DM715AS RU https://pubmed.ncbi.nlm.nih.gov/11512051 DM5WETL DI DM5WETL DM5WETL DN (S)-FTY720P DM5WETL MI TT9JZCK DM5WETL MN Sphingosine-1-phosphate receptor 1 (S1PR1) DM5WETL MT DTT DM5WETL MA Inhibitor DM5WETL RN Persistent signaling induced by FTY720-phosphate is mediated by internalized S1P1 receptors. Nat Chem Biol. 2009 Jun;5(6):428-34. DM5WETL RU https://pubmed.ncbi.nlm.nih.gov/19430484 DM8H0ND DI DM8H0ND DM8H0ND DN (S)-Methyl 4-(2-oxohexadecanamido)octanoate DM8H0ND MI TTT1JVS DM8H0ND MN Cytosolic phospholipase A2 (GIVA cPLA2) DM8H0ND MT DTT DM8H0ND MA Inhibitor DM8H0ND RN Structure-activity relationships of natural and non-natural amino acid-based amide and 2-oxoamide inhibitors of human phospholipase A(2) enzymes. Bioorg Med Chem. 2008 Dec 15;16(24):10257-69. DM8H0ND RU https://pubmed.ncbi.nlm.nih.gov/18993078 DMLR0N3 DI DMLR0N3 DMLR0N3 DN (S)-N-(1-phenylethyl)acetimidamide hydrobromide DMLR0N3 MI TTF10I9 DMLR0N3 MN Nitric-oxide synthase inducible (NOS2) DMLR0N3 MT DTT DMLR0N3 MA Inhibitor DMLR0N3 RN N-Substituted acetamidines and 2-methylimidazole derivatives as selective inhibitors of neuronal nitric oxide synthase. Bioorg Med Chem Lett. 2010 Nov 15;20(22):6495-9. DMLR0N3 RU https://pubmed.ncbi.nlm.nih.gov/20933416 DMGFOQJ DI DMGFOQJ DMGFOQJ DN (S)-N-[1-(3-morpholin-4-yl-phenyl)-ethyl]-3-phenyl-acrylamide DMGFOQJ MI TTPXI3S DMGFOQJ MN Voltage-gated potassium channel Kv7.2 (KCNQ2) DMGFOQJ MT DTT DMGFOQJ MA Activator DMGFOQJ RN The acrylamide (S)-1 differentially affects Kv7 (KCNQ) potassium channels. Neuropharmacology. 2006 Nov;51(6):1068-77. DMGFOQJ RU https://pubmed.ncbi.nlm.nih.gov/16904708 DMGFOQJ DI DMGFOQJ DMGFOQJ DN (S)-N-[1-(3-morpholin-4-yl-phenyl)-ethyl]-3-phenyl-acrylamide DMGFOQJ MI TT8HGRW DMGFOQJ MN Voltage-gated potassium channel Kv7.4 (KCNQ4) DMGFOQJ MT DTT DMGFOQJ MA Activator DMGFOQJ RN The acrylamide (S)-1 differentially affects Kv7 (KCNQ) potassium channels. Neuropharmacology. 2006 Nov;51(6):1068-77. DMGFOQJ RU https://pubmed.ncbi.nlm.nih.gov/16904708 DMGFOQJ DI DMGFOQJ DMGFOQJ DN (S)-N-[1-(3-morpholin-4-yl-phenyl)-ethyl]-3-phenyl-acrylamide DMGFOQJ MI TTWVL5Q DMGFOQJ MN Voltage-gated potassium channel Kv7.5 (KCNQ5) DMGFOQJ MT DTT DMGFOQJ MA Activator DMGFOQJ RN The acrylamide (S)-1 differentially affects Kv7 (KCNQ) potassium channels. Neuropharmacology. 2006 Nov;51(6):1068-77. DMGFOQJ RU https://pubmed.ncbi.nlm.nih.gov/16904708 DMGMAPB DI DMGMAPB DMGMAPB DN (S)-N2-[4-(benzyloxy)benzyl]alaninamide DMGMAPB MI TTGP7BY DMGMAPB MN Monoamine oxidase type B (MAO-B) DMGMAPB MT DTT DMGMAPB MA Inhibitor DMGMAPB RN Solid-phase synthesis and insights into structure-activity relationships of safinamide analogues as potent and selective inhibitors of type B monoa... J Med Chem. 2007 Oct 4;50(20):4909-16. DMGMAPB RU https://pubmed.ncbi.nlm.nih.gov/17824599 DMW5ZK7 DI DMW5ZK7 DMW5ZK7 DN (S)-N2-[4-(benzyloxy)benzyl]serinamide DMW5ZK7 MI TTGP7BY DMW5ZK7 MN Monoamine oxidase type B (MAO-B) DMW5ZK7 MT DTT DMW5ZK7 MA Inhibitor DMW5ZK7 RN Solid-phase synthesis and insights into structure-activity relationships of safinamide analogues as potent and selective inhibitors of type B monoa... J Med Chem. 2007 Oct 4;50(20):4909-16. DMW5ZK7 RU https://pubmed.ncbi.nlm.nih.gov/17824599 DMKMJBL DI DMKMJBL DMKMJBL DN (S)-N2-{4-[(3-chlorobenzyl)oxy]benzyl}alaninamide DMKMJBL MI TTGP7BY DMKMJBL MN Monoamine oxidase type B (MAO-B) DMKMJBL MT DTT DMKMJBL MA Inhibitor DMKMJBL RN Solid-phase synthesis and insights into structure-activity relationships of safinamide analogues as potent and selective inhibitors of type B monoa... J Med Chem. 2007 Oct 4;50(20):4909-16. DMKMJBL RU https://pubmed.ncbi.nlm.nih.gov/17824599 DMINLCJ DI DMINLCJ DMINLCJ DN (S)-N2-{4-[(3-chlorobenzyl)oxy]benzyl}serinamide DMINLCJ MI TTGP7BY DMINLCJ MN Monoamine oxidase type B (MAO-B) DMINLCJ MT DTT DMINLCJ MA Inhibitor DMINLCJ RN Solid-phase synthesis and insights into structure-activity relationships of safinamide analogues as potent and selective inhibitors of type B monoa... J Med Chem. 2007 Oct 4;50(20):4909-16. DMINLCJ RU https://pubmed.ncbi.nlm.nih.gov/17824599 DMSC8ZW DI DMSC8ZW DMSC8ZW DN (S)-N2-{4-[(3-fluorobenzyl)oxy]benzyl}serinamide DMSC8ZW MI TTGP7BY DMSC8ZW MN Monoamine oxidase type B (MAO-B) DMSC8ZW MT DTT DMSC8ZW MA Inhibitor DMSC8ZW RN Solid-phase synthesis and insights into structure-activity relationships of safinamide analogues as potent and selective inhibitors of type B monoa... J Med Chem. 2007 Oct 4;50(20):4909-16. DMSC8ZW RU https://pubmed.ncbi.nlm.nih.gov/17824599 DMU3F7H DI DMU3F7H DMU3F7H DN (S)-N2-{4-[(4-chlorobenzyl)oxy]benzyl}alaninamide DMU3F7H MI TTGP7BY DMU3F7H MN Monoamine oxidase type B (MAO-B) DMU3F7H MT DTT DMU3F7H MA Inhibitor DMU3F7H RN Solid-phase synthesis and insights into structure-activity relationships of safinamide analogues as potent and selective inhibitors of type B monoa... J Med Chem. 2007 Oct 4;50(20):4909-16. DMU3F7H RU https://pubmed.ncbi.nlm.nih.gov/17824599 DMLFOPV DI DMLFOPV DMLFOPV DN (S)-N2-{4-[(4-chlorobenzyl)oxy]benzyl}serinamide DMLFOPV MI TTGP7BY DMLFOPV MN Monoamine oxidase type B (MAO-B) DMLFOPV MT DTT DMLFOPV MA Inhibitor DMLFOPV RN Solid-phase synthesis and insights into structure-activity relationships of safinamide analogues as potent and selective inhibitors of type B monoa... J Med Chem. 2007 Oct 4;50(20):4909-16. DMLFOPV RU https://pubmed.ncbi.nlm.nih.gov/17824599 DMLP63J DI DMLP63J DMLP63J DN (S)-N2-{4-[(4-nitrobenzyl)oxy]benzyl}serinamide DMLP63J MI TTGP7BY DMLP63J MN Monoamine oxidase type B (MAO-B) DMLP63J MT DTT DMLP63J MA Inhibitor DMLP63J RN Solid-phase synthesis and insights into structure-activity relationships of safinamide analogues as potent and selective inhibitors of type B monoa... J Med Chem. 2007 Oct 4;50(20):4909-16. DMLP63J RU https://pubmed.ncbi.nlm.nih.gov/17824599 DMUAYZJ DI DMUAYZJ DMUAYZJ DN (S)-N-isobutyl-N-(pyrrolidin-3-yl)-2-naphthamide DMUAYZJ MI TTAWNKZ DMUAYZJ MN Norepinephrine transporter (NET) DMUAYZJ MT DTT DMUAYZJ MA Inhibitor DMUAYZJ RN Bioorg Med Chem Lett. 2009 Oct 15;19(20):5893-7. Epub 2009 Aug 21.Design and optimisation of selective serotonin re-uptake inhibitors with high synthetic accessibility: part 2. DMUAYZJ RU https://pubmed.ncbi.nlm.nih.gov/19740658 DMUAYZJ DI DMUAYZJ DMUAYZJ DN (S)-N-isobutyl-N-(pyrrolidin-3-yl)-2-naphthamide DMUAYZJ MI TT3ROYC DMUAYZJ MN Serotonin transporter (SERT) DMUAYZJ MT DTT DMUAYZJ MA Inhibitor DMUAYZJ RN Bioorg Med Chem Lett. 2009 Oct 15;19(20):5893-7. Epub 2009 Aug 21.Design and optimisation of selective serotonin re-uptake inhibitors with high synthetic accessibility: part 2. DMUAYZJ RU https://pubmed.ncbi.nlm.nih.gov/19740658 DMNOWZ2 DI DMNOWZ2 DMNOWZ2 DN (S)-N-oleoyltyrosinol DMNOWZ2 MI TT7QNVC DMNOWZ2 MN Glucose-dependent insulinotropic receptor (GPR119) DMNOWZ2 MT DTT DMNOWZ2 MA Agonist DMNOWZ2 RN N-oleoyldopamine enhances glucose homeostasis through the activation of GPR119. Mol Endocrinol. 2010 Jan;24(1):161-70. DMNOWZ2 RU https://pubmed.ncbi.nlm.nih.gov/19901198 DMULFYA DI DMULFYA DMULFYA DN (S)-NORDULOXETINE DMULFYA MI TTAWNKZ DMULFYA MN Norepinephrine transporter (NET) DMULFYA MT DTT DMULFYA MA Inhibitor DMULFYA RN Inhibition of serotonin and norepinephrine reuptake and inhibition of phosphodiesterase by multi-target inhibitors as potential agents for depression. Bioorg Med Chem. 2009 Oct 1;17(19):6890-7. DMULFYA RU https://pubmed.ncbi.nlm.nih.gov/19740668 DMULFYA DI DMULFYA DMULFYA DN (S)-NORDULOXETINE DMULFYA MI TT3ROYC DMULFYA MN Serotonin transporter (SERT) DMULFYA MT DTT DMULFYA MA Inhibitor DMULFYA RN Inhibition of serotonin and norepinephrine reuptake and inhibition of phosphodiesterase by multi-target inhibitors as potential agents for depression. Bioorg Med Chem. 2009 Oct 1;17(19):6890-7. DMULFYA RU https://pubmed.ncbi.nlm.nih.gov/19740668 DM8ZTPF DI DM8ZTPF DM8ZTPF DN (S)-Norfluoxetine DM8ZTPF MI TTVBI8W DM8ZTPF MN Dopamine transporter (DAT) DM8ZTPF MT DTT DM8ZTPF MA Inhibitor DM8ZTPF RN Stereoselective inhibition of serotonin re-uptake and phosphodiesterase by dual inhibitors as potential agents for depression. Bioorg Med Chem. 2009 Jan 1;17(1):337-43. DM8ZTPF RU https://pubmed.ncbi.nlm.nih.gov/19014888 DM8ZTPF DI DM8ZTPF DM8ZTPF DN (S)-Norfluoxetine DM8ZTPF MI TTAWNKZ DM8ZTPF MN Norepinephrine transporter (NET) DM8ZTPF MT DTT DM8ZTPF MA Inhibitor DM8ZTPF RN Stereoselective inhibition of serotonin re-uptake and phosphodiesterase by dual inhibitors as potential agents for depression. Bioorg Med Chem. 2009 Jan 1;17(1):337-43. DM8ZTPF RU https://pubmed.ncbi.nlm.nih.gov/19014888 DM8ZTPF DI DM8ZTPF DM8ZTPF DN (S)-Norfluoxetine DM8ZTPF MI TT3ROYC DM8ZTPF MN Serotonin transporter (SERT) DM8ZTPF MT DTT DM8ZTPF MA Inhibitor DM8ZTPF RN Stereoselective inhibition of serotonin re-uptake and phosphodiesterase by dual inhibitors as potential agents for depression. Bioorg Med Chem. 2009 Jan 1;17(1):337-43. DM8ZTPF RU https://pubmed.ncbi.nlm.nih.gov/19014888 DMAI1HU DI DMAI1HU DMAI1HU DN (S)-phenylglycine DMAI1HU MI TTFK1JQ DMAI1HU MN Voltage-gated calcium channel alpha-2/delta-1 (CACNA2D1) DMAI1HU MT DTT DMAI1HU MA Inhibitor DMAI1HU RN Structure-activity relationships of alpha-amino acid ligands for the alpha2delta subunit of voltage-gated calcium channels. Bioorg Med Chem Lett. 2006 Mar 1;16(5):1138-41. DMAI1HU RU https://pubmed.ncbi.nlm.nih.gov/16380257 DM04BHI DI DM04BHI DM04BHI DN (S)-PIA DM04BHI MI TTK25J1 DM04BHI MN Adenosine A1 receptor (ADORA1) DM04BHI MT DTT DM04BHI MA Agonist DM04BHI RN A threonine residue in the seventh transmembrane domain of the human A1 adenosine receptor mediates specific agonist binding. J Biol Chem. 1994 Jan 28;269(4):2373-6. DM04BHI RU https://pubmed.ncbi.nlm.nih.gov/8300561 DM04BHI DI DM04BHI DM04BHI DN (S)-PIA DM04BHI MI TTNE7KG DM04BHI MN Adenosine A2b receptor (ADORA2B) DM04BHI MT DTT DM04BHI MA Agonist DM04BHI RN Characterization of human A(2B) adenosine receptors: radioligand binding, western blotting, and coupling to G(q) in human embryonic kidney 293 cells and HMC-1 mast cells. Mol Pharmacol. 1999 Oct;56(4):705-13. DM04BHI RU https://pubmed.ncbi.nlm.nih.gov/10496952 DM04BHI DI DM04BHI DM04BHI DN (S)-PIA DM04BHI MI TTJFY5U DM04BHI MN Adenosine A3 receptor (ADORA3) DM04BHI MT DTT DM04BHI MA Agonist DM04BHI RN [(3)H]MRE 3008F20: a novel antagonist radioligand for the pharmacological and biochemical characterization of human A(3) adenosine receptors. Mol Pharmacol. 2000 May;57(5):968-75. DM04BHI RU https://pubmed.ncbi.nlm.nih.gov/10779381 DMST89H DI DMST89H DMST89H DN (S)-Piperidine-3-carboxylic acid DMST89H MI TTPRKM0 DMST89H MN GABA transporter GAT-1 (SLC6A1) DMST89H MT DTT DMST89H MA Inhibitor DMST89H RN Novel secoergoline derivatives inhibit both GABA and glutamate uptake in rat brain homogenates: synthesis, in vitro pharmacology, and modeling. J Med Chem. 2004 Nov 4;47(23):5620-9. DMST89H RU https://pubmed.ncbi.nlm.nih.gov/15509161 DMXVQJI DI DMXVQJI DMXVQJI DN (S)-pyrrolidin-1-yl(pyrrolidin-2-yl)methanone DMXVQJI MI TTDIGC1 DMXVQJI MN Dipeptidyl peptidase 4 (DPP-4) DMXVQJI MT DTT DMXVQJI MA Inhibitor DMXVQJI RN Design and synthesis of DPP-IV inhibitors lacking the electrophilic nitrile group. Bioorg Med Chem. 2008 Feb 15;16(4):1613-31. DMXVQJI RU https://pubmed.ncbi.nlm.nih.gov/18039579 DM16N7Z DI DM16N7Z DM16N7Z DN (S)-pyrrolidin-2-yl(thiazolidin-3-yl)methanone DM16N7Z MI TTDIGC1 DM16N7Z MN Dipeptidyl peptidase 4 (DPP-4) DM16N7Z MT DTT DM16N7Z MA Inhibitor DM16N7Z RN [(S)-gamma-(4-Aryl-1-piperazinyl)-l-prolyl]thiazolidines as a novel series of highly potent and long-lasting DPP-IV inhibitors. Bioorg Med Chem Lett. 2007 May 1;17(9):2618-21. DM16N7Z RU https://pubmed.ncbi.nlm.nih.gov/17317162 DM1SJZ3 DI DM1SJZ3 DM1SJZ3 DN (S)-Rolipram DM1SJZ3 MI TTV5CGO DM1SJZ3 MN Phosphodiesterase 4 (PDE4) DM1SJZ3 MT DTT DM1SJZ3 MA Inhibitor DM1SJZ3 RN PDE4 inhibitors roflumilast and rolipram augment PGE2 inhibition of TGF-{beta}1-stimulated fibroblasts. Am J Physiol Lung Cell Mol Physiol. 2009 Jun;296(6):L959-69. DM1SJZ3 RU https://pubmed.ncbi.nlm.nih.gov/19304913 DM1SJZ3 DI DM1SJZ3 DM1SJZ3 DN (S)-Rolipram DM1SJZ3 MI TTZ97H5 DM1SJZ3 MN Phosphodiesterase 4A (PDE4A) DM1SJZ3 MT DTT DM1SJZ3 MA Inhibitor DM1SJZ3 RN PDE4 inhibitors roflumilast and rolipram augment PGE2 inhibition of TGF-{beta}1-stimulated fibroblasts. Am J Physiol Lung Cell Mol Physiol. 2009 Jun;296(6):L959-69. DM1SJZ3 RU https://pubmed.ncbi.nlm.nih.gov/19304913 DM1SJZ3 DI DM1SJZ3 DM1SJZ3 DN (S)-Rolipram DM1SJZ3 MI TTVIAT9 DM1SJZ3 MN Phosphodiesterase 4B (PDE4B) DM1SJZ3 MT DTT DM1SJZ3 MA Inhibitor DM1SJZ3 RN PDE4 inhibitors roflumilast and rolipram augment PGE2 inhibition of TGF-{beta}1-stimulated fibroblasts. Am J Physiol Lung Cell Mol Physiol. 2009 Jun;296(6):L959-69. DM1SJZ3 RU https://pubmed.ncbi.nlm.nih.gov/19304913 DMG4KIU DI DMG4KIU DMG4KIU DN (S)-secoantioquine hydrochloride DMG4KIU MI TTEX248 DMG4KIU MN Dopamine D2 receptor (D2R) DMG4KIU MT DTT DMG4KIU MA Inhibitor DMG4KIU RN Displacement activity of bisbenzylisoquinoline alkaloids at striatal 3H-SCH 23390 and 3H-raclopride binding sites. J Nat Prod. 1992 Sep;55(9):1281-6. DMG4KIU RU https://pubmed.ncbi.nlm.nih.gov/1431946 DMS8WG3 DI DMS8WG3 DMS8WG3 DN (S)-sirtinol DMS8WG3 MI TTUF2HO DMS8WG3 MN NAD-dependent deacetylase sirtuin-1 (SIRT1) DMS8WG3 MT DTT DMS8WG3 MA Inhibitor DMS8WG3 RN Design, synthesis, and biological evaluation of sirtinol analogues as class III histone/protein deacetylase (Sirtuin) inhibitors. J Med Chem. 2005 Dec 1;48(24):7789-95. DMS8WG3 RU https://pubmed.ncbi.nlm.nih.gov/16302818 DMH7QZ2 DI DMH7QZ2 DMH7QZ2 DN (S)-tacrine(10)-hupyridone DMH7QZ2 MI TT1RS9F DMH7QZ2 MN Acetylcholinesterase (AChE) DMH7QZ2 MT DTT DMH7QZ2 MA Inhibitor DMH7QZ2 RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DMH7QZ2 RU https://pubmed.ncbi.nlm.nih.gov/10592235 DM68XFZ DI DM68XFZ DM68XFZ DN (S)-TBPG DM68XFZ MI TTVBPDM DM68XFZ MN Metabotropic glutamate receptor 1 (mGluR1) DM68XFZ MT DTT DM68XFZ MA Antagonist DM68XFZ RN Synthesis and biological evaluation of 2-(3'-(1H-tetrazol-5-yl) bicyclo[1.1.1]pent-1-yl)glycine (S-TBPG), a novel mGlu1 receptor antagonist. Bioorg Med Chem. 2001 Feb;9(2):221-7. DM68XFZ RU https://pubmed.ncbi.nlm.nih.gov/11249114 DMAQX4K DI DMAQX4K DMAQX4K DN (S)-tert-butyl 1-oxohexan-2-ylcarbamate DMAQX4K MI TTDZN01 DMAQX4K MN Cathepsin K (CTSK) DMAQX4K MT DTT DMAQX4K MA Inhibitor DMAQX4K RN Semicarbazone-based inhibitors of cathepsin K, are they prodrugs for aldehyde inhibitors Bioorg Med Chem Lett. 2006 Feb 15;16(4):978-83. DMAQX4K RU https://pubmed.ncbi.nlm.nih.gov/16290936 DMAQX4K DI DMAQX4K DMAQX4K DN (S)-tert-butyl 1-oxohexan-2-ylcarbamate DMAQX4K MI TT36ETB DMAQX4K MN Cathepsin L (CTSL) DMAQX4K MT DTT DMAQX4K MA Inhibitor DMAQX4K RN Semicarbazone-based inhibitors of cathepsin K, are they prodrugs for aldehyde inhibitors Bioorg Med Chem Lett. 2006 Feb 15;16(4):978-83. DMAQX4K RU https://pubmed.ncbi.nlm.nih.gov/16290936 DMLG8Q2 DI DMLG8Q2 DMLG8Q2 DN (S)-tert-Butyl 4-(2-oxohexadecanamido)pentanoate DMLG8Q2 MI TTT1JVS DMLG8Q2 MN Cytosolic phospholipase A2 (GIVA cPLA2) DMLG8Q2 MT DTT DMLG8Q2 MA Inhibitor DMLG8Q2 RN Structure-activity relationships of natural and non-natural amino acid-based amide and 2-oxoamide inhibitors of human phospholipase A(2) enzymes. Bioorg Med Chem. 2008 Dec 15;16(24):10257-69. DMLG8Q2 RU https://pubmed.ncbi.nlm.nih.gov/18993078 DMR1HQ3 DI DMR1HQ3 DMR1HQ3 DN (S)-tert-butyl 4-methyl-1-oxopentan-2-ylcarbamate DMR1HQ3 MI TTDZN01 DMR1HQ3 MN Cathepsin K (CTSK) DMR1HQ3 MT DTT DMR1HQ3 MA Inhibitor DMR1HQ3 RN Semicarbazone-based inhibitors of cathepsin K, are they prodrugs for aldehyde inhibitors Bioorg Med Chem Lett. 2006 Feb 15;16(4):978-83. DMR1HQ3 RU https://pubmed.ncbi.nlm.nih.gov/16290936 DMXQ47M DI DMXQ47M DMXQ47M DN (S)-WILLARDIINE DMXQ47M MI TTAN6JD DMXQ47M MN Glutamate receptor AMPA (GRIA) DMXQ47M MT DTT DMXQ47M MA Inhibitor DMXQ47M RN Synthesis of willardiine and 6-azawillardiine analogs: pharmacological characterization on cloned homomeric human AMPA and kainate receptor subtypes. J Med Chem. 1997 Oct 24;40(22):3645-50. DMXQ47M RU https://pubmed.ncbi.nlm.nih.gov/9357531 DMXQ47M DI DMXQ47M DMXQ47M DN (S)-WILLARDIINE DMXQ47M MI TTVPQTF DMXQ47M MN Glutamate receptor AMPA 1 (GRIA1) DMXQ47M MT DTT DMXQ47M MA Inhibitor DMXQ47M RN Synthesis of willardiine and 6-azawillardiine analogs: pharmacological characterization on cloned homomeric human AMPA and kainate receptor subtypes. J Med Chem. 1997 Oct 24;40(22):3645-50. DMXQ47M RU https://pubmed.ncbi.nlm.nih.gov/9357531 DM6BON2 DI DM6BON2 DM6BON2 DN (S)-zacopride DM6BON2 MI TTPC4TU DM6BON2 MN 5-HT 3A receptor (HTR3A) DM6BON2 MT DTT DM6BON2 MA Antagonist DM6BON2 RN Pharmacological comparison of human homomeric 5-HT3A receptors versus heteromeric 5-HT3A/3B receptors. Neuropharmacology. 2001 Aug;41(2):282-4. DM6BON2 RU https://pubmed.ncbi.nlm.nih.gov/11489465 DM6BON2 DI DM6BON2 DM6BON2 DN (S)-zacopride DM6BON2 MI TTR6K75 DM6BON2 MN 5-HT 3B receptor (HTR3B) DM6BON2 MT DTT DM6BON2 MA Antagonist DM6BON2 RN Pharmacological comparison of human homomeric 5-HT3A receptors versus heteromeric 5-HT3A/3B receptors. Neuropharmacology. 2001 Aug;41(2):282-4. DM6BON2 RU https://pubmed.ncbi.nlm.nih.gov/11489465 DMA30RW DI DMA30RW DMA30RW DN (S,R)-(+)-fenoterol DMA30RW MI TT2CJVK DMA30RW MN Adrenergic receptor beta-2 (ADRB2) DMA30RW MT DTT DMA30RW MA Inhibitor DMA30RW RN Comparative molecular field analysis of the binding of the stereoisomers of fenoterol and fenoterol derivatives to the beta2 adrenergic receptor. J Med Chem. 2007 Jun 14;50(12):2903-15. DMA30RW RU https://pubmed.ncbi.nlm.nih.gov/17506540 DMIV0MT DI DMIV0MT DMIV0MT DN (S,R)-antioquine hydrochloride DMIV0MT MI TTEX248 DMIV0MT MN Dopamine D2 receptor (D2R) DMIV0MT MT DTT DMIV0MT MA Inhibitor DMIV0MT RN Displacement activity of bisbenzylisoquinoline alkaloids at striatal 3H-SCH 23390 and 3H-raclopride binding sites. J Nat Prod. 1992 Sep;55(9):1281-6. DMIV0MT RU https://pubmed.ncbi.nlm.nih.gov/1431946 DMZV52W DI DMZV52W DMZV52W DN (S,R)-isotetrandrine hydrochloride DMZV52W MI TTEX248 DMZV52W MN Dopamine D2 receptor (D2R) DMZV52W MT DTT DMZV52W MA Inhibitor DMZV52W RN Displacement activity of bisbenzylisoquinoline alkaloids at striatal 3H-SCH 23390 and 3H-raclopride binding sites. J Nat Prod. 1992 Sep;55(9):1281-6. DMZV52W RU https://pubmed.ncbi.nlm.nih.gov/1431946 DMMRUVF DI DMMRUVF DMMRUVF DN (S,R)-pseudoxandrine hydrochloride DMMRUVF MI TTEX248 DMMRUVF MN Dopamine D2 receptor (D2R) DMMRUVF MT DTT DMMRUVF MA Inhibitor DMMRUVF RN Displacement activity of bisbenzylisoquinoline alkaloids at striatal 3H-SCH 23390 and 3H-raclopride binding sites. J Nat Prod. 1992 Sep;55(9):1281-6. DMMRUVF RU https://pubmed.ncbi.nlm.nih.gov/1431946 DMBR1JS DI DMBR1JS DMBR1JS DN (S,S)-(-)-bis(10)-hupyridone DMBR1JS MI TT1RS9F DMBR1JS MN Acetylcholinesterase (AChE) DMBR1JS MT DTT DMBR1JS MA Inhibitor DMBR1JS RN Exploiting protein fluctuations at the active-site gorge of human cholinesterases: further optimization of the design strategy to develop extremely... J Med Chem. 2008 Jun 12;51(11):3154-70. DMBR1JS RU https://pubmed.ncbi.nlm.nih.gov/18479118 DM6PQ8D DI DM6PQ8D DM6PQ8D DN (S,S)-(-)-bis(12)-hupyridone DM6PQ8D MI TT1RS9F DM6PQ8D MN Acetylcholinesterase (AChE) DM6PQ8D MT DTT DM6PQ8D MA Inhibitor DM6PQ8D RN Exploiting protein fluctuations at the active-site gorge of human cholinesterases: further optimization of the design strategy to develop extremely... J Med Chem. 2008 Jun 12;51(11):3154-70. DM6PQ8D RU https://pubmed.ncbi.nlm.nih.gov/18479118 DMYDS6F DI DMYDS6F DMYDS6F DN (S,S)-oxandrine hydrochloride DMYDS6F MI TTZFYLI DMYDS6F MN Dopamine D1 receptor (D1R) DMYDS6F MT DTT DMYDS6F MA Inhibitor DMYDS6F RN Displacement activity of bisbenzylisoquinoline alkaloids at striatal 3H-SCH 23390 and 3H-raclopride binding sites. J Nat Prod. 1992 Sep;55(9):1281-6. DMYDS6F RU https://pubmed.ncbi.nlm.nih.gov/1431946 DMYDS6F DI DMYDS6F DMYDS6F DN (S,S)-oxandrine hydrochloride DMYDS6F MI TTEX248 DMYDS6F MN Dopamine D2 receptor (D2R) DMYDS6F MT DTT DMYDS6F MA Inhibitor DMYDS6F RN Displacement activity of bisbenzylisoquinoline alkaloids at striatal 3H-SCH 23390 and 3H-raclopride binding sites. J Nat Prod. 1992 Sep;55(9):1281-6. DMYDS6F RU https://pubmed.ncbi.nlm.nih.gov/1431946 DMJL8SE DI DMJL8SE DMJL8SE DN (Sar)WTLNSAGYLLGPKK(Lys-decanoyl)K DMJL8SE MI TTX3HNZ DMJL8SE MN Galanin receptor type 1 (GAL1-R) DMJL8SE MT DTT DMJL8SE MA Inhibitor DMJL8SE RN Structural requirements for a lipoamino acid in modulating the anticonvulsant activities of systemically active galanin analogues. J Med Chem. 2009 Mar 12;52(5):1310-6. DMJL8SE RU https://pubmed.ncbi.nlm.nih.gov/19199479 DMJL8SE DI DMJL8SE DMJL8SE DN (Sar)WTLNSAGYLLGPKK(Lys-decanoyl)K DMJL8SE MI TTBPW3J DMJL8SE MN Galanin receptor type 2 (GAL2-R) DMJL8SE MT DTT DMJL8SE MA Inhibitor DMJL8SE RN Structural requirements for a lipoamino acid in modulating the anticonvulsant activities of systemically active galanin analogues. J Med Chem. 2009 Mar 12;52(5):1310-6. DMJL8SE RU https://pubmed.ncbi.nlm.nih.gov/19199479 DMPZHIE DI DMPZHIE DMPZHIE DN (Sar)WTLNSAGYLLGPKK(Lys-lauroyl)K DMPZHIE MI TTX3HNZ DMPZHIE MN Galanin receptor type 1 (GAL1-R) DMPZHIE MT DTT DMPZHIE MA Inhibitor DMPZHIE RN Structural requirements for a lipoamino acid in modulating the anticonvulsant activities of systemically active galanin analogues. J Med Chem. 2009 Mar 12;52(5):1310-6. DMPZHIE RU https://pubmed.ncbi.nlm.nih.gov/19199479 DMPZHIE DI DMPZHIE DMPZHIE DN (Sar)WTLNSAGYLLGPKK(Lys-lauroyl)K DMPZHIE MI TTBPW3J DMPZHIE MN Galanin receptor type 2 (GAL2-R) DMPZHIE MT DTT DMPZHIE MA Inhibitor DMPZHIE RN Structural requirements for a lipoamino acid in modulating the anticonvulsant activities of systemically active galanin analogues. J Med Chem. 2009 Mar 12;52(5):1310-6. DMPZHIE RU https://pubmed.ncbi.nlm.nih.gov/19199479 DMQIHZU DI DMQIHZU DMQIHZU DN (Sar)WTLNSAGYLLGPKK(Lys-MPEG4)K DMQIHZU MI TTX3HNZ DMQIHZU MN Galanin receptor type 1 (GAL1-R) DMQIHZU MT DTT DMQIHZU MA Inhibitor DMQIHZU RN Structural requirements for a lipoamino acid in modulating the anticonvulsant activities of systemically active galanin analogues. J Med Chem. 2009 Mar 12;52(5):1310-6. DMQIHZU RU https://pubmed.ncbi.nlm.nih.gov/19199479 DMQIHZU DI DMQIHZU DMQIHZU DN (Sar)WTLNSAGYLLGPKK(Lys-MPEG4)K DMQIHZU MI TTBPW3J DMQIHZU MN Galanin receptor type 2 (GAL2-R) DMQIHZU MT DTT DMQIHZU MA Inhibitor DMQIHZU RN Structural requirements for a lipoamino acid in modulating the anticonvulsant activities of systemically active galanin analogues. J Med Chem. 2009 Mar 12;52(5):1310-6. DMQIHZU RU https://pubmed.ncbi.nlm.nih.gov/19199479 DMVHDF4 DI DMVHDF4 DMVHDF4 DN (Sar)WTLNSAGYLLGPKK(Lys-myristoyl)K DMVHDF4 MI TTX3HNZ DMVHDF4 MN Galanin receptor type 1 (GAL1-R) DMVHDF4 MT DTT DMVHDF4 MA Inhibitor DMVHDF4 RN Structural requirements for a lipoamino acid in modulating the anticonvulsant activities of systemically active galanin analogues. J Med Chem. 2009 Mar 12;52(5):1310-6. DMVHDF4 RU https://pubmed.ncbi.nlm.nih.gov/19199479 DMVHDF4 DI DMVHDF4 DMVHDF4 DN (Sar)WTLNSAGYLLGPKK(Lys-myristoyl)K DMVHDF4 MI TTBPW3J DMVHDF4 MN Galanin receptor type 2 (GAL2-R) DMVHDF4 MT DTT DMVHDF4 MA Inhibitor DMVHDF4 RN Structural requirements for a lipoamino acid in modulating the anticonvulsant activities of systemically active galanin analogues. J Med Chem. 2009 Mar 12;52(5):1310-6. DMVHDF4 RU https://pubmed.ncbi.nlm.nih.gov/19199479 DMX3K4E DI DMX3K4E DMX3K4E DN (Sar)WTLNSAGYLLGPKK(Lys-octanoyl)K DMX3K4E MI TTX3HNZ DMX3K4E MN Galanin receptor type 1 (GAL1-R) DMX3K4E MT DTT DMX3K4E MA Inhibitor DMX3K4E RN Structural requirements for a lipoamino acid in modulating the anticonvulsant activities of systemically active galanin analogues. J Med Chem. 2009 Mar 12;52(5):1310-6. DMX3K4E RU https://pubmed.ncbi.nlm.nih.gov/19199479 DMX3K4E DI DMX3K4E DMX3K4E DN (Sar)WTLNSAGYLLGPKK(Lys-octanoyl)K DMX3K4E MI TTBPW3J DMX3K4E MN Galanin receptor type 2 (GAL2-R) DMX3K4E MT DTT DMX3K4E MA Inhibitor DMX3K4E RN Structural requirements for a lipoamino acid in modulating the anticonvulsant activities of systemically active galanin analogues. J Med Chem. 2009 Mar 12;52(5):1310-6. DMX3K4E RU https://pubmed.ncbi.nlm.nih.gov/19199479 DMSVMI8 DI DMSVMI8 DMSVMI8 DN (Sar)WTLNSAGYLLGPKK(Lys-palmitoyl)K DMSVMI8 MI TTX3HNZ DMSVMI8 MN Galanin receptor type 1 (GAL1-R) DMSVMI8 MT DTT DMSVMI8 MA Inhibitor DMSVMI8 RN Structural requirements for a lipoamino acid in modulating the anticonvulsant activities of systemically active galanin analogues. J Med Chem. 2009 Mar 12;52(5):1310-6. DMSVMI8 RU https://pubmed.ncbi.nlm.nih.gov/19199479 DMSVMI8 DI DMSVMI8 DMSVMI8 DN (Sar)WTLNSAGYLLGPKK(Lys-palmitoyl)K DMSVMI8 MI TTBPW3J DMSVMI8 MN Galanin receptor type 2 (GAL2-R) DMSVMI8 MT DTT DMSVMI8 MA Inhibitor DMSVMI8 RN Structural requirements for a lipoamino acid in modulating the anticonvulsant activities of systemically active galanin analogues. J Med Chem. 2009 Mar 12;52(5):1310-6. DMSVMI8 RU https://pubmed.ncbi.nlm.nih.gov/19199479 DMO6N7C DI DMO6N7C DMO6N7C DN (Sar)WTLNSAGYLLGPKK(Lys-stearoyl)K DMO6N7C MI TTX3HNZ DMO6N7C MN Galanin receptor type 1 (GAL1-R) DMO6N7C MT DTT DMO6N7C MA Inhibitor DMO6N7C RN Structural requirements for a lipoamino acid in modulating the anticonvulsant activities of systemically active galanin analogues. J Med Chem. 2009 Mar 12;52(5):1310-6. DMO6N7C RU https://pubmed.ncbi.nlm.nih.gov/19199479 DMO6N7C DI DMO6N7C DMO6N7C DN (Sar)WTLNSAGYLLGPKK(Lys-stearoyl)K DMO6N7C MI TTBPW3J DMO6N7C MN Galanin receptor type 2 (GAL2-R) DMO6N7C MT DTT DMO6N7C MA Inhibitor DMO6N7C RN Structural requirements for a lipoamino acid in modulating the anticonvulsant activities of systemically active galanin analogues. J Med Chem. 2009 Mar 12;52(5):1310-6. DMO6N7C RU https://pubmed.ncbi.nlm.nih.gov/19199479 DMT2NVG DI DMT2NVG DMT2NVG DN (Sar)WTLNSAGYLLGPKKKK DMT2NVG MI TTX3HNZ DMT2NVG MN Galanin receptor type 1 (GAL1-R) DMT2NVG MT DTT DMT2NVG MA Inhibitor DMT2NVG RN Structural requirements for a lipoamino acid in modulating the anticonvulsant activities of systemically active galanin analogues. J Med Chem. 2009 Mar 12;52(5):1310-6. DMT2NVG RU https://pubmed.ncbi.nlm.nih.gov/19199479 DMT2NVG DI DMT2NVG DMT2NVG DN (Sar)WTLNSAGYLLGPKKKK DMT2NVG MI TTBPW3J DMT2NVG MN Galanin receptor type 2 (GAL2-R) DMT2NVG MT DTT DMT2NVG MA Inhibitor DMT2NVG RN Structural requirements for a lipoamino acid in modulating the anticonvulsant activities of systemically active galanin analogues. J Med Chem. 2009 Mar 12;52(5):1310-6. DMT2NVG RU https://pubmed.ncbi.nlm.nih.gov/19199479 DMT3S72 DI DMT3S72 DMT3S72 DN (South)-Methanocarba-Thymidine DMT3S72 MI TTP3QRF DMT3S72 MN Thymidine kinase 1 (TK1) DMT3S72 MT DTT DMT3S72 MA Inhibitor DMT3S72 RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMT3S72 RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMLW7TV DI DMLW7TV DMLW7TV DN (Tert-Butyloxycarbonyl)-Alanyl-Alanyl-Amine DMLW7TV MI TT3NKIB DMLW7TV MN Pancreatic elastase 1 (CELA1) DMLW7TV MT DTT DMLW7TV MA Inhibitor DMLW7TV RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMLW7TV RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMVZYNH DI DMVZYNH DMVZYNH DN (Z)-1-(4-phenyloxazol-2-yl)octadec-9-en-1-one DMVZYNH MI TTDP1UC DMVZYNH MN Fatty acid amide hydrolase (FAAH) DMVZYNH MT DTT DMVZYNH MA Inhibitor DMVZYNH RN Inhibitors of proteases and amide hydrolases that employ an alpha-ketoheterocycle as a key enabling functionality. Bioorg Med Chem. 2008 Feb 15;16(4):1562-95. DMVZYNH RU https://pubmed.ncbi.nlm.nih.gov/18053726 DMNBDGH DI DMNBDGH DMNBDGH DN (Z)-1-(benzo[d]oxazol-2-yl)octadec-9-en-1-one DMNBDGH MI TTDP1UC DMNBDGH MN Fatty acid amide hydrolase (FAAH) DMNBDGH MT DTT DMNBDGH MA Inhibitor DMNBDGH RN Inhibitors of proteases and amide hydrolases that employ an alpha-ketoheterocycle as a key enabling functionality. Bioorg Med Chem. 2008 Feb 15;16(4):1562-95. DMNBDGH RU https://pubmed.ncbi.nlm.nih.gov/18053726 DMMTXKO DI DMMTXKO DMMTXKO DN (Z)-1-(pyridazin-3-yl)octadec-9-en-1-one DMMTXKO MI TTDP1UC DMMTXKO MN Fatty acid amide hydrolase (FAAH) DMMTXKO MT DTT DMMTXKO MA Inhibitor DMMTXKO RN Inhibitors of proteases and amide hydrolases that employ an alpha-ketoheterocycle as a key enabling functionality. Bioorg Med Chem. 2008 Feb 15;16(4):1562-95. DMMTXKO RU https://pubmed.ncbi.nlm.nih.gov/18053726 DMSVBZO DI DMSVBZO DMSVBZO DN (Z)-1,1,1,2,2,3,3-heptafluorohenicos-12-en-4-one DMSVBZO MI TTT1JVS DMSVBZO MN Cytosolic phospholipase A2 (GIVA cPLA2) DMSVBZO MT DTT DMSVBZO MA Inhibitor DMSVBZO RN Potent and selective fluoroketone inhibitors of group VIA calcium-independent phospholipase A2. J Med Chem. 2010 May 13;53(9):3602-10. DMSVBZO RU https://pubmed.ncbi.nlm.nih.gov/20369880 DMBTMDG DI DMBTMDG DMBTMDG DN (Z)-1,1,1-Trifluoro-nonadec-10-en-2-one DMBTMDG MI TTDP1UC DMBTMDG MN Fatty acid amide hydrolase (FAAH) DMBTMDG MT DTT DMBTMDG MA Inhibitor DMBTMDG RN Discovery of a potent, selective, and efficacious class of reversible alpha-ketoheterocycle inhibitors of fatty acid amide hydrolase effective as a... J Med Chem. 2005 Mar 24;48(6):1849-56. DMBTMDG RU https://pubmed.ncbi.nlm.nih.gov/15771430 DMKQ679 DI DMKQ679 DMKQ679 DN (Z)-2-(1-decyl-2-oxoindolin-3-ylidene)acetic acid DMKQ679 MI TTLZS4Q DMKQ679 MN M-phase inducer phosphatase 1 (MPIP1) DMKQ679 MT DTT DMKQ679 MA Inhibitor DMKQ679 RN Design and synthesis of N-alkyl oxindolylidene acetic acids as a new class of potent Cdc25A inhibitors. Bioorg Med Chem Lett. 2008 Jun 1;18(11):3350-3. DMKQ679 RU https://pubmed.ncbi.nlm.nih.gov/18442908 DM2HZX8 DI DM2HZX8 DM2HZX8 DN (Z)-2,2-Dimethyl-1-oxazol-2-yl-octadec-9-en-1-one DM2HZX8 MI TTDP1UC DM2HZX8 MN Fatty acid amide hydrolase (FAAH) DM2HZX8 MT DTT DM2HZX8 MA Inhibitor DM2HZX8 RN alpha-Keto heterocycle inhibitors of fatty acid amide hydrolase: carbonyl group modification and alpha-substitution. Bioorg Med Chem Lett. 2001 Jun 18;11(12):1517-20. DM2HZX8 RU https://pubmed.ncbi.nlm.nih.gov/11412972 DMFLDPU DI DMFLDPU DMFLDPU DN (Z)-2,6-diisopropyl-N-phenyloctadec-9-enamide DMFLDPU MI TTK3C21 DMFLDPU MN Acetoacetyl-CoA thiolase (ACAT1) DMFLDPU MT DTT DMFLDPU MA Inhibitor DMFLDPU RN Biphenyl versus phenylpyridazine derivatives: the role of the heterocycle in a series of acyl-CoA:cholesterol acyl transferase inhibitors. J Med Chem. 2008 Mar 13;51(5):1474-7. DMFLDPU RU https://pubmed.ncbi.nlm.nih.gov/18284184 DM0OEQJ DI DM0OEQJ DM0OEQJ DN (Z)-2'-des-methyl sulindac sulfide DM0OEQJ MI TT8NGED DM0OEQJ MN Prostaglandin G/H synthase 1 (COX-1) DM0OEQJ MT DTT DM0OEQJ MA Inhibitor DM0OEQJ RN The influence of double bond geometry in the inhibition of cyclooxygenases by sulindac derivatives. Bioorg Med Chem Lett. 2009 Jun 15;19(12):3271-4. DM0OEQJ RU https://pubmed.ncbi.nlm.nih.gov/19427206 DM0OEQJ DI DM0OEQJ DM0OEQJ DN (Z)-2'-des-methyl sulindac sulfide DM0OEQJ MI TTVKILB DM0OEQJ MN Prostaglandin G/H synthase 2 (COX-2) DM0OEQJ MT DTT DM0OEQJ MA Inhibitor DM0OEQJ RN The influence of double bond geometry in the inhibition of cyclooxygenases by sulindac derivatives. Bioorg Med Chem Lett. 2009 Jun 15;19(12):3271-4. DM0OEQJ RU https://pubmed.ncbi.nlm.nih.gov/19427206 DMYH9BC DI DMYH9BC DMYH9BC DN (Z)-2-Methyl-1-oxazol-2-yl-octadec-9-en-1-one DMYH9BC MI TTDP1UC DMYH9BC MN Fatty acid amide hydrolase (FAAH) DMYH9BC MT DTT DMYH9BC MA Inhibitor DMYH9BC RN alpha-Keto heterocycle inhibitors of fatty acid amide hydrolase: carbonyl group modification and alpha-substitution. Bioorg Med Chem Lett. 2001 Jun 18;11(12):1517-20. DMYH9BC RU https://pubmed.ncbi.nlm.nih.gov/11412972 DM18R6J DI DM18R6J DM18R6J DN (Z)-2-Methyl-3-tetradecyl-but-2-enedioic acid DM18R6J MI TT7WZIJ DM18R6J MN CAAX farnesyltransferase beta (FNTB) DM18R6J MT DTT DM18R6J MA Inhibitor DM18R6J RN Ras farnesyltransferase: a new therapeutic target. J Med Chem. 1997 Sep 12;40(19):2971-90. DM18R6J RU https://pubmed.ncbi.nlm.nih.gov/9301658 DM18R6J DI DM18R6J DM18R6J DN (Z)-2-Methyl-3-tetradecyl-but-2-enedioic acid DM18R6J MI TTXQKM3 DM18R6J MN Farnesyl protein transferase (Ftase) DM18R6J MT DTT DM18R6J MA Inhibitor DM18R6J RN Ras farnesyltransferase: a new therapeutic target. J Med Chem. 1997 Sep 12;40(19):2971-90. DM18R6J RU https://pubmed.ncbi.nlm.nih.gov/9301658 DM27WDP DI DM27WDP DM27WDP DN (Z)-3-((1H-pyrrol-2-yl)methylene)indolin-2-one DM27WDP MI TTYMGWX DM27WDP MN PDK-1 messenger RNA (PDK-1 mRNA) DM27WDP MT DTT DM27WDP MA Inhibitor DM27WDP RN Indolinone based phosphoinositide-dependent kinase-1 (PDK1) inhibitors. Part 1: design, synthesis and biological activity. Bioorg Med Chem Lett. 2007 Jul 15;17(14):3814-8. DM27WDP RU https://pubmed.ncbi.nlm.nih.gov/17531483 DM27WDP DI DM27WDP DM27WDP DN (Z)-3-((1H-pyrrol-2-yl)methylene)indolin-2-one DM27WDP MI TT4DXQT DM27WDP MN Proto-oncogene c-Ret (RET) DM27WDP MT DTT DM27WDP MA Inhibitor DM27WDP RN Synthesis, structure-activity relationship and crystallographic studies of 3-substituted indolin-2-one RET inhibitors. Bioorg Med Chem. 2010 Feb 15;18(4):1482-96. DM27WDP RU https://pubmed.ncbi.nlm.nih.gov/20117004 DM27WDP DI DM27WDP DM27WDP DN (Z)-3-((1H-pyrrol-2-yl)methylene)indolin-2-one DM27WDP MI TTWTSCV DM27WDP MN RAC-alpha serine/threonine-protein kinase (AKT1) DM27WDP MT DTT DM27WDP MA Inhibitor DM27WDP RN Indolinone based phosphoinositide-dependent kinase-1 (PDK1) inhibitors. Part 1: design, synthesis and biological activity. Bioorg Med Chem Lett. 2007 Jul 15;17(14):3814-8. DM27WDP RU https://pubmed.ncbi.nlm.nih.gov/17531483 DMIQ14F DI DMIQ14F DMIQ14F DN (Z)-3-[2-(9H-fluoren-2-yloxy)ethylidene]-quinuclidine hydrochloride 31 DMIQ14F MI TTFQEO5 DMIQ14F MN Squalene synthetase (FDFT1) DMIQ14F MT DTT DMIQ14F MA Inhibitor DMIQ14F RN Syntheses and biological evaluation of novel quinuclidine derivatives as squalene synthase inhibitors. Bioorg Med Chem. 2003 May 29;11(11):2403-14. DMIQ14F RU https://pubmed.ncbi.nlm.nih.gov/12735986 DM30YQF DI DM30YQF DM30YQF DN (Z)-4-(4-hexylphenylamino)-4-oxobut-2-enoic acid DM30YQF MI TTTSEPU DM30YQF MN Thyroid hormone receptor alpha (THRA) DM30YQF MT DTT DM30YQF MA Inhibitor DM30YQF RN Inhibitors of the interaction of a thyroid hormone receptor and coactivators: preliminary structure-activity relationships. J Med Chem. 2007 Nov 1;50(22):5269-80. DM30YQF RU https://pubmed.ncbi.nlm.nih.gov/17918822 DM30YQF DI DM30YQF DM30YQF DN (Z)-4-(4-hexylphenylamino)-4-oxobut-2-enoic acid DM30YQF MI TTGER3L DM30YQF MN Thyroid hormone receptor beta (THRB) DM30YQF MT DTT DM30YQF MA Inhibitor DM30YQF RN Inhibitors of the interaction of a thyroid hormone receptor and coactivators: preliminary structure-activity relationships. J Med Chem. 2007 Nov 1;50(22):5269-80. DM30YQF RU https://pubmed.ncbi.nlm.nih.gov/17918822 DMPJAKL DI DMPJAKL DMPJAKL DN (Z)-5-Amino-3-(4-methoxybenzylidene)indolin-2-one DMPJAKL MI TT4DXQT DMPJAKL MN Proto-oncogene c-Ret (RET) DMPJAKL MT DTT DMPJAKL MA Inhibitor DMPJAKL RN Synthesis, structure-activity relationship and crystallographic studies of 3-substituted indolin-2-one RET inhibitors. Bioorg Med Chem. 2010 Feb 15;18(4):1482-96. DMPJAKL RU https://pubmed.ncbi.nlm.nih.gov/20117004 DM3ALJD DI DM3ALJD DM3ALJD DN (Z)-5-Benzylidene-2-thioxothiazolidin-4-one DM3ALJD MI TT1K6Q4 DM3ALJD MN Arylamine N-acetyltransferase (NAT) DM3ALJD MT DTT DM3ALJD MA Inhibitor DM3ALJD RN Selective small molecule inhibitors of the potential breast cancer marker, human arylamine N-acetyltransferase 1, and its murine homologue, mouse a... Bioorg Med Chem. 2009 Jan 15;17(2):905-18. DM3ALJD RU https://pubmed.ncbi.nlm.nih.gov/19059786 DMLRWAF DI DMLRWAF DMLRWAF DN (Z)-5-Butylidene-2-thioxothiazolidin-4-one DMLRWAF MI TT1K6Q4 DMLRWAF MN Arylamine N-acetyltransferase (NAT) DMLRWAF MT DTT DMLRWAF MA Inhibitor DMLRWAF RN Selective small molecule inhibitors of the potential breast cancer marker, human arylamine N-acetyltransferase 1, and its murine homologue, mouse a... Bioorg Med Chem. 2009 Jan 15;17(2):905-18. DMLRWAF RU https://pubmed.ncbi.nlm.nih.gov/19059786 DM5U1M8 DI DM5U1M8 DM5U1M8 DN (Z)-5-Decylidene-2-thioxothiazolidin-4-one DM5U1M8 MI TT1K6Q4 DM5U1M8 MN Arylamine N-acetyltransferase (NAT) DM5U1M8 MT DTT DM5U1M8 MA Inhibitor DM5U1M8 RN Selective small molecule inhibitors of the potential breast cancer marker, human arylamine N-acetyltransferase 1, and its murine homologue, mouse a... Bioorg Med Chem. 2009 Jan 15;17(2):905-18. DM5U1M8 RU https://pubmed.ncbi.nlm.nih.gov/19059786 DMV70YA DI DMV70YA DMV70YA DN (Z)-5-Hexylidene-2-thioxothiazolidin-4-one DMV70YA MI TT1K6Q4 DMV70YA MN Arylamine N-acetyltransferase (NAT) DMV70YA MT DTT DMV70YA MA Inhibitor DMV70YA RN Selective small molecule inhibitors of the potential breast cancer marker, human arylamine N-acetyltransferase 1, and its murine homologue, mouse a... Bioorg Med Chem. 2009 Jan 15;17(2):905-18. DMV70YA RU https://pubmed.ncbi.nlm.nih.gov/19059786 DM4X9GW DI DM4X9GW DM4X9GW DN (Z)-5-octadecen-7,9-diynoic acid DM4X9GW MI TTPADOQ DM4X9GW MN HMG-CoA reductase (HMGCR) DM4X9GW MT DTT DM4X9GW MA Inhibitor DM4X9GW RN Novel Acetylenic Acids from the Root Bark of Paramacrolobium caeruleum: Inhibitors of 3-Hydroxy-3-methyl-glutaryl Coenzyme A Reductase J. Nat. Prod. 52(1):153-161 (1989). DM4X9GW RU http://pubs.acs.org/doi/abs/10.1021/np50061a020 DMEJNFS DI DMEJNFS DMEJNFS DN (Z)-5-Octylidene-2-thioxothiazolidin-4-one DMEJNFS MI TT1K6Q4 DMEJNFS MN Arylamine N-acetyltransferase (NAT) DMEJNFS MT DTT DMEJNFS MA Inhibitor DMEJNFS RN Selective small molecule inhibitors of the potential breast cancer marker, human arylamine N-acetyltransferase 1, and its murine homologue, mouse a... Bioorg Med Chem. 2009 Jan 15;17(2):905-18. DMEJNFS RU https://pubmed.ncbi.nlm.nih.gov/19059786 DMKWLSB DI DMKWLSB DMKWLSB DN (Z)-7-octedecan-9-ynoic acid DMKWLSB MI TTPADOQ DMKWLSB MN HMG-CoA reductase (HMGCR) DMKWLSB MT DTT DMKWLSB MA Inhibitor DMKWLSB RN Novel Acetylenic Acids from the Root Bark of Paramacrolobium caeruleum: Inhibitors of 3-Hydroxy-3-methyl-glutaryl Coenzyme A Reductase J. Nat. Prod. 52(1):153-161 (1989). DMKWLSB RU http://pubs.acs.org/doi/abs/10.1021/np50061a020 DMOB9E4 DI DMOB9E4 DMOB9E4 DN (Z)-8-(3-chlorostyryl)caffeine DMOB9E4 MI TTM2AOE DMOB9E4 MN Adenosine A2a receptor (ADORA2A) DMOB9E4 MT DTT DMOB9E4 MA Inhibitor DMOB9E4 RN Dual inhibition of monoamine oxidase B and antagonism of the adenosine A(2A) receptor by (E,E)-8-(4-phenylbutadien-1-yl)caffeine analogues. Bioorg Med Chem. 2008 Sep 15;16(18):8676-84. DMOB9E4 RU https://pubmed.ncbi.nlm.nih.gov/18723354 DMX0G7E DI DMX0G7E DMX0G7E DN [(125)I] RB129 DMX0G7E MI TTPHMWB DMX0G7E MN Aminopeptidase N (ANPEP) DMX0G7E MT DTT DMX0G7E MA Inhibitor DMX0G7E RN Ontogenic and adult whole body distribution of aminopeptidase N in rat investigated by in vitro autoradiography. Biochimie. 2004 Feb;86(2):105-13. DMX0G7E RU https://pubmed.ncbi.nlm.nih.gov/15016448 DMX0G7E DI DMX0G7E DMX0G7E DN [(125)I] RB129 DMX0G7E MI TTN7BL9 DMX0G7E MN Corticosteroid 11-beta-dehydrogenase 1 (HSD11B1) DMX0G7E MT DTT DMX0G7E MA Inhibitor DMX0G7E RN Rapid hepatic metabolism of 7-ketocholesterol by 11beta-hydroxysteroid dehydrogenase type 1: species-specific differences between the rat, human, a... J Biol Chem. 2004 Apr 30;279(18):18415-24. DMX0G7E RU https://pubmed.ncbi.nlm.nih.gov/14973125 DMX0G7E DI DMX0G7E DMX0G7E DN [(125)I] RB129 DMX0G7E MI TT9H85R DMX0G7E MN Corticosteroid 11-beta-dehydrogenase 2 (HSD11B2) DMX0G7E MT DTT DMX0G7E MA Inhibitor DMX0G7E RN Abnormal expression of 11 beta-hydroxysteroid dehydrogenase type 2 in human pituitary adenomas: a prereceptor determinant of pituitary cell proliferation. Oncogene. 2003 Mar 20;22(11):1663-7. DMX0G7E RU https://pubmed.ncbi.nlm.nih.gov/12642869 DMG1ATX DI DMG1ATX DMG1ATX DN [(1e)-4-Phenylbut-1-Enyl]Benzene DMG1ATX MI TTGP7BY DMG1ATX MN Monoamine oxidase type B (MAO-B) DMG1ATX MT DTT DMG1ATX MA Inhibitor DMG1ATX RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DMG1ATX RU https://pubmed.ncbi.nlm.nih.gov/10592235 DM3WDOY DI DM3WDOY DM3WDOY DN [(2-aminooxyethyl)methylamino]-5'-deoxyadenosine DM3WDOY MI TTBFROQ DM3WDOY MN S-adenosylmethionine decarboxylase proenzyme (AMD1) DM3WDOY MT DTT DM3WDOY MA Inhibitor DM3WDOY RN New insights into the design of inhibitors of human S-adenosylmethionine decarboxylase: studies of adenine C8 substitution in structural analogues ... J Med Chem. 2009 Mar 12;52(5):1388-407. DM3WDOY RU https://pubmed.ncbi.nlm.nih.gov/19209891 DMTK9V7 DI DMTK9V7 DMTK9V7 DN [(3-Bromophenyl)-m-tolyl-ketone]thiosemicarbazone DMTK9V7 MI TT36ETB DMTK9V7 MN Cathepsin L (CTSL) DMTK9V7 MT DTT DMTK9V7 MA Inhibitor DMTK9V7 RN Design, synthesis, and biological evaluation of potent thiosemicarbazone based cathepsin L inhibitors. Bioorg Med Chem Lett. 2010 Feb 15;20(4):1415-9. DMTK9V7 RU https://pubmed.ncbi.nlm.nih.gov/20089402 DMZG7TH DI DMZG7TH DMZG7TH DN [(3-Bromophenyl)-p-tolyl-ketone]thiosemicarbazone DMZG7TH MI TTF2LRI DMZG7TH MN Cathepsin B (CTSB) DMZG7TH MT DTT DMZG7TH MA Inhibitor DMZG7TH RN Design, synthesis, and biological evaluation of potent thiosemicarbazone based cathepsin L inhibitors. Bioorg Med Chem Lett. 2010 Feb 15;20(4):1415-9. DMZG7TH RU https://pubmed.ncbi.nlm.nih.gov/20089402 DMZG7TH DI DMZG7TH DMZG7TH DN [(3-Bromophenyl)-p-tolyl-ketone]thiosemicarbazone DMZG7TH MI TT36ETB DMZG7TH MN Cathepsin L (CTSL) DMZG7TH MT DTT DMZG7TH MA Inhibitor DMZG7TH RN Design, synthesis, and biological evaluation of potent thiosemicarbazone based cathepsin L inhibitors. Bioorg Med Chem Lett. 2010 Feb 15;20(4):1415-9. DMZG7TH RU https://pubmed.ncbi.nlm.nih.gov/20089402 DM9YHA7 DI DM9YHA7 DM9YHA7 DN [(40-OH) MeLeu]4-CsA derivatives DM9YHA7 MI TT84ETX DM9YHA7 MN Human immunodeficiency virus Reverse transcriptase (HIV RT) DM9YHA7 MT DTT DM9YHA7 MA Inhibitor DM9YHA7 RN Synthesis of non-immunosuppressive cyclophilin-Binding cyclosporin A derivatives as potential anti-HIV-1 drugs. Bioorg Med Chem Lett. 2003 Dec 15;13(24):4415-9. DM9YHA7 RU https://pubmed.ncbi.nlm.nih.gov/14643337 DM1ZM5R DI DM1ZM5R DM1ZM5R DN [(40-OH)MeLeu]4-Cyclosporin A DM1ZM5R MI TT84ETX DM1ZM5R MN Human immunodeficiency virus Reverse transcriptase (HIV RT) DM1ZM5R MT DTT DM1ZM5R MA Inhibitor DM1ZM5R RN Synthesis of non-immunosuppressive cyclophilin-Binding cyclosporin A derivatives as potential anti-HIV-1 drugs. Bioorg Med Chem Lett. 2003 Dec 15;13(24):4415-9. DM1ZM5R RU https://pubmed.ncbi.nlm.nih.gov/14643337 DMV30N2 DI DMV30N2 DMV30N2 DN [(D)MeSer]3-[(40-OH) MeLeu]4-Cyclosporin A DMV30N2 MI TT84ETX DMV30N2 MN Human immunodeficiency virus Reverse transcriptase (HIV RT) DMV30N2 MT DTT DMV30N2 MA Inhibitor DMV30N2 RN Synthesis of non-immunosuppressive cyclophilin-Binding cyclosporin A derivatives as potential anti-HIV-1 drugs. Bioorg Med Chem Lett. 2003 Dec 15;13(24):4415-9. DMV30N2 RU https://pubmed.ncbi.nlm.nih.gov/14643337 DMVWCTL DI DMVWCTL DMVWCTL DN [(N4-Bzdig)0,Nle14]BB(7-14) DMVWCTL MI TTC1MVT DMVWCTL MN Gastrin-releasing peptide receptor (GRPR) DMVWCTL MT DTT DMVWCTL MA Inhibitor DMVWCTL RN Potent bombesin-like peptides for GRP-receptor targeting of tumors with 99mTc: a preclinical study. J Med Chem. 2005 Jan 13;48(1):100-10. DMVWCTL RU https://pubmed.ncbi.nlm.nih.gov/15634004 DMD4BSJ DI DMD4BSJ DMD4BSJ DN [(N4-Bzdig)0]BB(7-14) DMD4BSJ MI TTHYDUM DMD4BSJ MN Bombesin receptor (BS) DMD4BSJ MT DTT DMD4BSJ MA Inhibitor DMD4BSJ RN Potent bombesin-like peptides for GRP-receptor targeting of tumors with 99mTc: a preclinical study. J Med Chem. 2005 Jan 13;48(1):100-10. DMD4BSJ RU https://pubmed.ncbi.nlm.nih.gov/15634004 DMD4BSJ DI DMD4BSJ DMD4BSJ DN [(N4-Bzdig)0]BB(7-14) DMD4BSJ MI TTC1MVT DMD4BSJ MN Gastrin-releasing peptide receptor (GRPR) DMD4BSJ MT DTT DMD4BSJ MA Inhibitor DMD4BSJ RN Potent bombesin-like peptides for GRP-receptor targeting of tumors with 99mTc: a preclinical study. J Med Chem. 2005 Jan 13;48(1):100-10. DMD4BSJ RU https://pubmed.ncbi.nlm.nih.gov/15634004 DMPFUBE DI DMPFUBE DMPFUBE DN [(R)-(+)-deoxytylophorinidine DMPFUBE MI TTS7IR5 DMPFUBE MN c-Jun messenger RNA (c-Jun mRNA) DMPFUBE MT DTT DMPFUBE MA Inhibitor DMPFUBE RN Structure-activity studies of phenanthroindolizidine alkaloids as potential antitumor agents. Bioorg Med Chem Lett. 2007 Aug 1;17(15):4338-42. DMPFUBE RU https://pubmed.ncbi.nlm.nih.gov/17531481 DMU9F2P DI DMU9F2P DMU9F2P DN [[4-(Aminomethyl)Phenyl]Amino]Oxo-Acetic Acid, DMU9F2P MI TTELIN2 DMU9F2P MN PTPN1 messenger RNA (PTPN1 mRNA) DMU9F2P MT DTT DMU9F2P MA Inhibitor DMU9F2P RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMU9F2P RU https://pubmed.ncbi.nlm.nih.gov/17139284 DM86305 DI DM86305 DM86305 DN [[N-(Benzyloxycarbonyl)Amino]Methyl]Phosphate DM86305 MI TTHI19T DM86305 MN Staphylococcus Beta-lactamase (Stap-coc blaZ) DM86305 MT DTT DM86305 MA Inhibitor DM86305 RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DM86305 RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMAGW3R DI DMAGW3R DMAGW3R DN [1-(4-p-Tolyl-butyl)-piperidin-4-yl]-methanol DMAGW3R MI TTQ6VDM DMAGW3R MN Voltage-gated potassium channel Kv11.1 (KCNH2) DMAGW3R MT DTT DMAGW3R MA Inhibitor DMAGW3R RN Structural determinants for histamine H(1) affinity, hERG affinity and QTc prolongation in a series of terfenadine analogs. Bioorg Med Chem Lett. 2009 Sep 1;19(17):5043-7. DMAGW3R RU https://pubmed.ncbi.nlm.nih.gov/19660947 DMVOY4D DI DMVOY4D DMVOY4D DN [1,1':2',1'']-terphenyl-4,3'',5''-triol DMVOY4D MI TT3OT40 DMVOY4D MN Multidrug resistance protein 1 (ABCB1) DMVOY4D MT DTT DMVOY4D MA Inhibitor DMVOY4D RN Identification of a terphenyl derivative that blocks the cell cycle in the G0-G1 phase and induces differentiation in leukemia cells. J Med Chem. 2006 May 18;49(10):3012-8. DMVOY4D RU https://pubmed.ncbi.nlm.nih.gov/16686543 DMVOY4D DI DMVOY4D DMVOY4D DN [1,1':2',1'']-terphenyl-4,3'',5''-triol DMVOY4D MI TT3PJMV DMVOY4D MN Tyrosine-protein kinase ABL1 (ABL) DMVOY4D MT DTT DMVOY4D MA Inhibitor DMVOY4D RN Identification of a terphenyl derivative that blocks the cell cycle in the G0-G1 phase and induces differentiation in leukemia cells. J Med Chem. 2006 May 18;49(10):3012-8. DMVOY4D RU https://pubmed.ncbi.nlm.nih.gov/16686543 DMFXA8P DI DMFXA8P DMFXA8P DN [1,1':2',1'']Terphenyl-4'-carbaldehyde oxime DMFXA8P MI TTZAYWL DMFXA8P MN Estrogen receptor (ESR) DMFXA8P MT DTT DMFXA8P MA Inhibitor DMFXA8P RN Novel estrogen receptor ligands based on an anthranylaldoxime structure: role of the phenol-type pseudocycle in the binding process. J Med Chem. 2003 Sep 11;46(19):4032-42. DMFXA8P RU https://pubmed.ncbi.nlm.nih.gov/12954056 DMFXA8P DI DMFXA8P DMFXA8P DN [1,1':2',1'']Terphenyl-4'-carbaldehyde oxime DMFXA8P MI TTOM3J0 DMFXA8P MN Estrogen receptor beta (ESR2) DMFXA8P MT DTT DMFXA8P MA Inhibitor DMFXA8P RN Novel estrogen receptor ligands based on an anthranylaldoxime structure: role of the phenol-type pseudocycle in the binding process. J Med Chem. 2003 Sep 11;46(19):4032-42. DMFXA8P RU https://pubmed.ncbi.nlm.nih.gov/12954056 DMPV0QN DI DMPV0QN DMPV0QN DN [1,2,4]triazolo[1,5-a]quinoxalin-4(5H)-one DMPV0QN MI TTJFY5U DMPV0QN MN Adenosine A3 receptor (ADORA3) DMPV0QN MT DTT DMPV0QN MA Inhibitor DMPV0QN RN 1,2,4-Triazolo[1,5-a]quinoxaline as a versatile tool for the design of selective human A3 adenosine receptor antagonists: synthesis, biological eva... J Med Chem. 2005 Dec 15;48(25):7932-45. DMPV0QN RU https://pubmed.ncbi.nlm.nih.gov/16335918 DMDX6W4 DI DMDX6W4 DMDX6W4 DN [1,3]Oxazinan-(2E)-ylideneamine DMDX6W4 MI TTZUFI5 DMDX6W4 MN Nitric-oxide synthase brain (NOS1) DMDX6W4 MT DTT DMDX6W4 MA Inhibitor DMDX6W4 RN 2-Iminopiperidine and other 2-iminoazaheterocycles as potent inhibitors of human nitric oxide synthase isoforms. J Med Chem. 1996 Feb 2;39(3):669-72. DMDX6W4 RU https://pubmed.ncbi.nlm.nih.gov/8576908 DMDX6W4 DI DMDX6W4 DMDX6W4 DN [1,3]Oxazinan-(2E)-ylideneamine DMDX6W4 MI TTCM4B3 DMDX6W4 MN Nitric-oxide synthase endothelial (NOS3) DMDX6W4 MT DTT DMDX6W4 MA Inhibitor DMDX6W4 RN 2-Iminopiperidine and other 2-iminoazaheterocycles as potent inhibitors of human nitric oxide synthase isoforms. J Med Chem. 1996 Feb 2;39(3):669-72. DMDX6W4 RU https://pubmed.ncbi.nlm.nih.gov/8576908 DMDX6W4 DI DMDX6W4 DMDX6W4 DN [1,3]Oxazinan-(2E)-ylideneamine DMDX6W4 MI TTF10I9 DMDX6W4 MN Nitric-oxide synthase inducible (NOS2) DMDX6W4 MT DTT DMDX6W4 MA Inhibitor DMDX6W4 RN 2-Iminopiperidine and other 2-iminoazaheterocycles as potent inhibitors of human nitric oxide synthase isoforms. J Med Chem. 1996 Feb 2;39(3):669-72. DMDX6W4 RU https://pubmed.ncbi.nlm.nih.gov/8576908 DMOEIHC DI DMOEIHC DMOEIHC DN [1,3]Thiazinan-(2E)-ylideneamine DMOEIHC MI TTZUFI5 DMOEIHC MN Nitric-oxide synthase brain (NOS1) DMOEIHC MT DTT DMOEIHC MA Inhibitor DMOEIHC RN 2-Iminopiperidine and other 2-iminoazaheterocycles as potent inhibitors of human nitric oxide synthase isoforms. J Med Chem. 1996 Feb 2;39(3):669-72. DMOEIHC RU https://pubmed.ncbi.nlm.nih.gov/8576908 DMOEIHC DI DMOEIHC DMOEIHC DN [1,3]Thiazinan-(2E)-ylideneamine DMOEIHC MI TTCM4B3 DMOEIHC MN Nitric-oxide synthase endothelial (NOS3) DMOEIHC MT DTT DMOEIHC MA Inhibitor DMOEIHC RN 2-Iminopiperidine and other 2-iminoazaheterocycles as potent inhibitors of human nitric oxide synthase isoforms. J Med Chem. 1996 Feb 2;39(3):669-72. DMOEIHC RU https://pubmed.ncbi.nlm.nih.gov/8576908 DMOEIHC DI DMOEIHC DMOEIHC DN [1,3]Thiazinan-(2E)-ylideneamine DMOEIHC MI TTF10I9 DMOEIHC MN Nitric-oxide synthase inducible (NOS2) DMOEIHC MT DTT DMOEIHC MA Inhibitor DMOEIHC RN 2-Iminopiperidine and other 2-iminoazaheterocycles as potent inhibitors of human nitric oxide synthase isoforms. J Med Chem. 1996 Feb 2;39(3):669-72. DMOEIHC RU https://pubmed.ncbi.nlm.nih.gov/8576908 DMX58NK DI DMX58NK DMX58NK DN [1,4]Oxazepan-(3E)-ylideneamine DMX58NK MI TTZUFI5 DMX58NK MN Nitric-oxide synthase brain (NOS1) DMX58NK MT DTT DMX58NK MA Inhibitor DMX58NK RN Synthesis of analogs of (1,4)-3- and 5-imino oxazepane, thiazepane, and diazepane as inhibitors of nitric oxide synthases. Bioorg Med Chem Lett. 2004 Dec 6;14(23):5907-11. DMX58NK RU https://pubmed.ncbi.nlm.nih.gov/15501067 DMX58NK DI DMX58NK DMX58NK DN [1,4]Oxazepan-(3E)-ylideneamine DMX58NK MI TTCM4B3 DMX58NK MN Nitric-oxide synthase endothelial (NOS3) DMX58NK MT DTT DMX58NK MA Inhibitor DMX58NK RN Synthesis of analogs of (1,4)-3- and 5-imino oxazepane, thiazepane, and diazepane as inhibitors of nitric oxide synthases. Bioorg Med Chem Lett. 2004 Dec 6;14(23):5907-11. DMX58NK RU https://pubmed.ncbi.nlm.nih.gov/15501067 DMX58NK DI DMX58NK DMX58NK DN [1,4]Oxazepan-(3E)-ylideneamine DMX58NK MI TTF10I9 DMX58NK MN Nitric-oxide synthase inducible (NOS2) DMX58NK MT DTT DMX58NK MA Inhibitor DMX58NK RN Synthesis of analogs of (1,4)-3- and 5-imino oxazepane, thiazepane, and diazepane as inhibitors of nitric oxide synthases. Bioorg Med Chem Lett. 2004 Dec 6;14(23):5907-11. DMX58NK RU https://pubmed.ncbi.nlm.nih.gov/15501067 DMMUZVS DI DMMUZVS DMMUZVS DN [1,4]Oxazepan-(5E)-ylideneamine DMMUZVS MI TTZUFI5 DMMUZVS MN Nitric-oxide synthase brain (NOS1) DMMUZVS MT DTT DMMUZVS MA Inhibitor DMMUZVS RN Synthesis of analogs of (1,4)-3- and 5-imino oxazepane, thiazepane, and diazepane as inhibitors of nitric oxide synthases. Bioorg Med Chem Lett. 2004 Dec 6;14(23):5907-11. DMMUZVS RU https://pubmed.ncbi.nlm.nih.gov/15501067 DMMUZVS DI DMMUZVS DMMUZVS DN [1,4]Oxazepan-(5E)-ylideneamine DMMUZVS MI TTF10I9 DMMUZVS MN Nitric-oxide synthase inducible (NOS2) DMMUZVS MT DTT DMMUZVS MA Inhibitor DMMUZVS RN Synthesis of analogs of (1,4)-3- and 5-imino oxazepane, thiazepane, and diazepane as inhibitors of nitric oxide synthases. Bioorg Med Chem Lett. 2004 Dec 6;14(23):5907-11. DMMUZVS RU https://pubmed.ncbi.nlm.nih.gov/15501067 DMCBFJQ DI DMCBFJQ DMCBFJQ DN [1,4]Thiazepan-(3E)-ylideneamine DMCBFJQ MI TTZUFI5 DMCBFJQ MN Nitric-oxide synthase brain (NOS1) DMCBFJQ MT DTT DMCBFJQ MA Inhibitor DMCBFJQ RN Synthesis of analogs of (1,4)-3- and 5-imino oxazepane, thiazepane, and diazepane as inhibitors of nitric oxide synthases. Bioorg Med Chem Lett. 2004 Dec 6;14(23):5907-11. DMCBFJQ RU https://pubmed.ncbi.nlm.nih.gov/15501067 DMCBFJQ DI DMCBFJQ DMCBFJQ DN [1,4]Thiazepan-(3E)-ylideneamine DMCBFJQ MI TTCM4B3 DMCBFJQ MN Nitric-oxide synthase endothelial (NOS3) DMCBFJQ MT DTT DMCBFJQ MA Inhibitor DMCBFJQ RN Synthesis of analogs of (1,4)-3- and 5-imino oxazepane, thiazepane, and diazepane as inhibitors of nitric oxide synthases. Bioorg Med Chem Lett. 2004 Dec 6;14(23):5907-11. DMCBFJQ RU https://pubmed.ncbi.nlm.nih.gov/15501067 DMCBFJQ DI DMCBFJQ DMCBFJQ DN [1,4]Thiazepan-(3E)-ylideneamine DMCBFJQ MI TTF10I9 DMCBFJQ MN Nitric-oxide synthase inducible (NOS2) DMCBFJQ MT DTT DMCBFJQ MA Inhibitor DMCBFJQ RN Synthesis of analogs of (1,4)-3- and 5-imino oxazepane, thiazepane, and diazepane as inhibitors of nitric oxide synthases. Bioorg Med Chem Lett. 2004 Dec 6;14(23):5907-11. DMCBFJQ RU https://pubmed.ncbi.nlm.nih.gov/15501067 DMFQ0Z4 DI DMFQ0Z4 DMFQ0Z4 DN [1,4]Thiazepan-(5E)-ylideneamine DMFQ0Z4 MI TTZUFI5 DMFQ0Z4 MN Nitric-oxide synthase brain (NOS1) DMFQ0Z4 MT DTT DMFQ0Z4 MA Inhibitor DMFQ0Z4 RN Synthesis of analogs of (1,4)-3- and 5-imino oxazepane, thiazepane, and diazepane as inhibitors of nitric oxide synthases. Bioorg Med Chem Lett. 2004 Dec 6;14(23):5907-11. DMFQ0Z4 RU https://pubmed.ncbi.nlm.nih.gov/15501067 DMFQ0Z4 DI DMFQ0Z4 DMFQ0Z4 DN [1,4]Thiazepan-(5E)-ylideneamine DMFQ0Z4 MI TTCM4B3 DMFQ0Z4 MN Nitric-oxide synthase endothelial (NOS3) DMFQ0Z4 MT DTT DMFQ0Z4 MA Inhibitor DMFQ0Z4 RN Synthesis of analogs of (1,4)-3- and 5-imino oxazepane, thiazepane, and diazepane as inhibitors of nitric oxide synthases. Bioorg Med Chem Lett. 2004 Dec 6;14(23):5907-11. DMFQ0Z4 RU https://pubmed.ncbi.nlm.nih.gov/15501067 DMFQ0Z4 DI DMFQ0Z4 DMFQ0Z4 DN [1,4]Thiazepan-(5E)-ylideneamine DMFQ0Z4 MI TTF10I9 DMFQ0Z4 MN Nitric-oxide synthase inducible (NOS2) DMFQ0Z4 MT DTT DMFQ0Z4 MA Inhibitor DMFQ0Z4 RN Synthesis of analogs of (1,4)-3- and 5-imino oxazepane, thiazepane, and diazepane as inhibitors of nitric oxide synthases. Bioorg Med Chem Lett. 2004 Dec 6;14(23):5907-11. DMFQ0Z4 RU https://pubmed.ncbi.nlm.nih.gov/15501067 DMF62JR DI DMF62JR DMF62JR DN [1,5]Thiazocan-(4E)-ylideneamine DMF62JR MI TTF10I9 DMF62JR MN Nitric-oxide synthase inducible (NOS2) DMF62JR MT DTT DMF62JR MA Inhibitor DMF62JR RN Selective heterocyclic amidine inhibitors of human inducible nitric oxide synthase. Bioorg Med Chem Lett. 2001 Oct 8;11(19):2651-3. DMF62JR RU https://pubmed.ncbi.nlm.nih.gov/11551770 DMMZUPX DI DMMZUPX DMMZUPX DN [11C]AZ10419369 DMMZUPX MI TTK8CXU DMMZUPX MN 5-HT 1B receptor (HTR1B) DMMZUPX MT DTT DMMZUPX MA Agonist DMMZUPX RN Quantitative analysis of [11C]AZ10419369 binding to 5-HT1B receptors in human brain. J Cereb Blood Flow Metab. 2011 Jan;31(1):113-23. DMMZUPX RU https://pubmed.ncbi.nlm.nih.gov/20424633 DMQP03A DI DMQP03A DMQP03A DN [11C]butylthio-TZTP DMQP03A MI TTOXS3C DMQP03A MN Muscarinic acetylcholine receptor (CHRM) DMQP03A MT DTT DMQP03A MA Agonist DMQP03A RN PET study of the M1-agonists [11C]xanomeline and [11C]butylthio-TZTP in monkey and man. Dementia. 1996 Jul-Aug;7(4):187-95. DMQP03A RU https://pubmed.ncbi.nlm.nih.gov/8835881 DM4ZANH DI DM4ZANH DM4ZANH DN [11C]DTBZ DM4ZANH MI TTNZRI3 DM4ZANH MN Synaptic vesicle amine transporter (SLC18A2) DM4ZANH MT DTT DM4ZANH MA Inhibitor DM4ZANH RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1012). DM4ZANH RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1012 DM5Q08F DI DM5Q08F DM5Q08F DN [11C]GlySar DM5Q08F MI TT5LF3C DM5Q08F MN Solute carrier family 15 member 1 (SLC15A1) DM5Q08F MT DTT DM5Q08F MA Modulator DM5Q08F RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 984). DM5Q08F RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=984 DM5Q08F DI DM5Q08F DM5Q08F DN [11C]GlySar DM5Q08F MI TT27Q3A DM5Q08F MN Solute carrier family 15 member 2 (SLC15A2) DM5Q08F MT DTT DM5Q08F MA Modulator DM5Q08F RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 985). DM5Q08F RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=985 DMQRSP7 DI DMQRSP7 DMQRSP7 DN [11C]MMTP DMQRSP7 MI TTVBPDM DMQRSP7 MN Metabotropic glutamate receptor 1 (mGluR1) DMQRSP7 MT DTT DMQRSP7 MA Modulator (allosteric modulator) DMQRSP7 RN Synthesis, in vitro and in vivo evaluation of [11C]MMTP: a potential PET ligand for mGluR1 receptors. Bioorg Med Chem Lett. 2010 Jun 15;20(12):3499-501. DMQRSP7 RU https://pubmed.ncbi.nlm.nih.gov/20494576 DMOZ8E3 DI DMOZ8E3 DMOZ8E3 DN [11C]SB207145 DMOZ8E3 MI TT07C3Y DMOZ8E3 MN 5-HT 4 receptor (HTR4) DMOZ8E3 MT DTT DMOZ8E3 MA Antagonist DMOZ8E3 RN Mass dose effects and in vivo affinity in brain PET receptor studies--a study of cerebral 5-HT4 receptor binding with [11C]SB207145. Nucl Med Biol. 2011 Nov;38(8):1085-91. DMOZ8E3 RU https://pubmed.ncbi.nlm.nih.gov/21831646 DMCQTYW DI DMCQTYW DMCQTYW DN [11C]volinanserin DMCQTYW MI TTJQOD7 DMCQTYW MN 5-HT 2A receptor (HTR2A) DMCQTYW MT DTT DMCQTYW MA Antagonist DMCQTYW RN Autoradiographic localization of 5-HT(2A) receptors in the human brain using [(3)H]M100907 and [(11)C]M100907. Synapse. 2000 Dec 15;38(4):421-31. DMCQTYW RU https://pubmed.ncbi.nlm.nih.gov/11044889 DMXIEA1 DI DMXIEA1 DMXIEA1 DN [11C]WAY100635 DMXIEA1 MI TTSQIFT DMXIEA1 MN 5-HT 1A receptor (HTR1A) DMXIEA1 MT DTT DMXIEA1 MA Antagonist DMXIEA1 RN [11C]-WAY100635 PET demonstrates marked 5-HT1A receptor changes in sporadic ALS. Brain. 2005 Apr;128(Pt 4):896-905. DMXIEA1 RU https://pubmed.ncbi.nlm.nih.gov/15689356 DM742L9 DI DM742L9 DM742L9 DN [11C]xanomeline DM742L9 MI TTOXS3C DM742L9 MN Muscarinic acetylcholine receptor (CHRM) DM742L9 MT DTT DM742L9 MA Agonist DM742L9 RN PET study of the M1-agonists [11C]xanomeline and [11C]butylthio-TZTP in monkey and man. Dementia. 1996 Jul-Aug;7(4):187-95. DM742L9 RU https://pubmed.ncbi.nlm.nih.gov/8835881 DMHWNOS DI DMHWNOS DMHWNOS DN [123I] iodobenzoyl 12-Ex4 DMHWNOS MI TTVIMDE DMHWNOS MN Glucagon-like peptide 1 receptor (GLP1R) DMHWNOS MT DTT DMHWNOS MA Modulator DMHWNOS RN 2005 approvals: Safety first. Nature Reviews Drug Discovery 5, 92-93 (February 2006). DMHWNOS RU http://www.nature.com/nrd/journal/v11/n1/full/nrd3645.html DMCJQ0P DI DMCJQ0P DMCJQ0P DN [123I]AM251 DMCJQ0P MI TT6OEDT DMCJQ0P MN Cannabinoid receptor 1 (CB1) DMCJQ0P MT DTT DMCJQ0P MA Antagonist DMCJQ0P RN Binding of the non-classical cannabinoid CP 55,940, and the diarylpyrazole AM251 to rodent brain cannabinoid receptors. Life Sci. 1997;61(14):PL 191-7. DMCJQ0P RU https://pubmed.ncbi.nlm.nih.gov/9335234 DMOZGLM DI DMOZGLM DMOZGLM DN [123I]iodobenzovesamicol DMOZGLM MI TTV8KWS DMOZGLM MN Vesicular acetylcholine transporter (SLC18A3) DMOZGLM MT DTT DMOZGLM MA Modulator DMOZGLM RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1013). DMOZGLM RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1013 DM5SRT1 DI DM5SRT1 DM5SRT1 DN [123I]iodoproxyfan DM5SRT1 MI TT9JNIC DM5SRT1 MN Histamine H3 receptor (H3R) DM5SRT1 MT DTT DM5SRT1 MA Antagonist DM5SRT1 RN Distinct pharmacology of rat and human histamine H(3) receptors: role of two amino acids in the third transmembrane domain. Br J Pharmacol. 2000 Dec;131(7):1247-50. DM5SRT1 RU https://pubmed.ncbi.nlm.nih.gov/11090094 DMMG1TA DI DMMG1TA DMMG1TA DN [123I]SB 207710 DMMG1TA MI TT07C3Y DMMG1TA MN 5-HT 4 receptor (HTR4) DMMG1TA MT DTT DMMG1TA MA Antagonist DMMG1TA RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 9). DMMG1TA RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=9 DMFT5N9 DI DMFT5N9 DMFT5N9 DN [125I]7-azido-8-iodoketanserine DMFT5N9 MI TTNZRI3 DMFT5N9 MN Synaptic vesicle amine transporter (SLC18A2) DMFT5N9 MT DTT DMFT5N9 MA Inhibitor DMFT5N9 RN Peptide mapping of the [125I]Iodoazidoketanserin and [125I]2-N-[(3'-iodo-4'-azidophenyl)propionyl]tetrabenazine binding sites for the synaptic vesicle monoamine transporter. J Biol Chem. 1997 Oct 10;272(41):26049-55. DMFT5N9 RU https://pubmed.ncbi.nlm.nih.gov/9325342 DM8EQFL DI DM8EQFL DM8EQFL DN [125I]AB-MECA DM8EQFL MI TTJFY5U DM8EQFL MN Adenosine A3 receptor (ADORA3) DM8EQFL MT DTT DM8EQFL MA Agonist DM8EQFL RN [(3)H]MRE 3008F20: a novel antagonist radioligand for the pharmacological and biochemical characterization of human A(3) adenosine receptors. Mol Pharmacol. 2000 May;57(5):968-75. DM8EQFL RU https://pubmed.ncbi.nlm.nih.gov/10779381 DMZBNK9 DI DMZBNK9 DMZBNK9 DN [125I]ABOPX DMZBNK9 MI TTNE7KG DMZBNK9 MN Adenosine A2b receptor (ADORA2B) DMZBNK9 MT DTT DMZBNK9 MA Antagonist DMZBNK9 RN Characterization of human A(2B) adenosine receptors: radioligand binding, western blotting, and coupling to G(q) in human embryonic kidney 293 cells and HMC-1 mast cells. Mol Pharmacol. 1999 Oct;56(4):705-13. DMZBNK9 RU https://pubmed.ncbi.nlm.nih.gov/10496952 DM95A4Z DI DM95A4Z DM95A4Z DN [125I]APNEA DM95A4Z MI TTJFY5U DM95A4Z MN Adenosine A3 receptor (ADORA3) DM95A4Z MT DTT DM95A4Z MA Agonist DM95A4Z RN Molecular cloning and characterization of an adenosine receptor: the A3 adenosine receptor. Proc Natl Acad Sci U S A. 1992 Aug 15;89(16):7432-6. DM95A4Z RU https://pubmed.ncbi.nlm.nih.gov/1323836 DMYBQOG DI DMYBQOG DMYBQOG DN [125I]-BDZ2 DMYBQOG MI TTVFO0U DMYBQOG MN Gastrin/cholecystokinin type B receptor (CCKBR) DMYBQOG MT DTT DMYBQOG MA Antagonist DMYBQOG RN Synthesis and in vitro characterization of radioiodinatable benzodiazepines selective for type 1 and type 2 cholecystokinin receptors. J Med Chem. 2009 Apr 9;52(7):2138-47. DMYBQOG RU https://pubmed.ncbi.nlm.nih.gov/19271701 DM7GVYF DI DM7GVYF DM7GVYF DN [125I]BE-2254 DM7GVYF MI TTBRKXS DM7GVYF MN Adrenergic receptor alpha-1B (ADRA1B) DM7GVYF MT DTT DM7GVYF MA Antagonist DM7GVYF RN Cloning and pharmacological characterization of human alpha-1 adrenergic receptors: sequence corrections and direct comparison with other species homologues. J Pharmacol Exp Ther. 1995 Jan;272(1):134-42. DM7GVYF RU https://pubmed.ncbi.nlm.nih.gov/7815325 DM7GVYF DI DM7GVYF DM7GVYF DN [125I]BE-2254 DM7GVYF MI TT2NUT5 DM7GVYF MN Adrenergic receptor alpha-2C (ADRA2C) DM7GVYF MT DTT DM7GVYF MA Antagonist DM7GVYF RN Cloning and pharmacological characterization of human alpha-1 adrenergic receptors: sequence corrections and direct comparison with other species homologues. J Pharmacol Exp Ther. 1995 Jan;272(1):134-42. DM7GVYF RU https://pubmed.ncbi.nlm.nih.gov/7815325 DMV6I7H DI DMV6I7H DMV6I7H DN [125I]BOP DMV6I7H MI TT2O84V DMV6I7H MN Thromboxane A2 receptor (TBXA2R) DMV6I7H MT DTT DMV6I7H MA Agonist DMV6I7H RN Characterization of an 125I-labeled thromboxane A2/prostaglandin H2 receptor agonist. J Pharmacol Exp Ther. 1989 Nov;251(2):557-62. DMV6I7H RU https://pubmed.ncbi.nlm.nih.gov/2530338 DM0X824 DI DM0X824 DM0X824 DN [125I]cetrorelix DM0X824 MI TT8R70G DM0X824 MN Gonadotropin-releasing hormone receptor (GNRHR) DM0X824 MT DTT DM0X824 MA Antagonist DM0X824 RN Residues within transmembrane helices 2 and 5 of the human gonadotropin-releasing hormone receptor contribute to agonist and antagonist binding. Mol Endocrinol. 2000 Jul;14(7):1099-115. DM0X824 RU https://pubmed.ncbi.nlm.nih.gov/10894158 DMIAO4V DI DMIAO4V DMIAO4V DN [125I]CGP 64213 DMIAO4V MI TTDCVZW DMIAO4V MN Gamma-aminobutyric acid B receptor (GABBR) DMIAO4V MT DTT DMIAO4V MA Antagonist DMIAO4V RN Ca(2+) requirement for high-affinity gamma-aminobutyric acid (GABA) binding at GABA(B) receptors: involvement of serine 269 of the GABA(B)R1 subunit. Mol Pharmacol. 2000 Mar;57(3):419-26. DMIAO4V RU https://pubmed.ncbi.nlm.nih.gov/10692480 DMQVW4E DI DMQVW4E DMQVW4E DN [125I]CGP 71872 DMQVW4E MI TTDCVZW DMQVW4E MN Gamma-aminobutyric acid B receptor (GABBR) DMQVW4E MT DTT DMQVW4E MA Antagonist DMQVW4E RN Expression cloning of GABA(B) receptors uncovers similarity to metabotropic glutamate receptors. Nature. 1997 Mar 20;386(6622):239-46. DMQVW4E RU https://pubmed.ncbi.nlm.nih.gov/9069281 DM1NXDA DI DM1NXDA DM1NXDA DN [125I]CGP42112 DM1NXDA MI TTQVOEI DM1NXDA MN Angiotensin II receptor type-2 (AGTR2) DM1NXDA MT DTT DM1NXDA MA Agonist DM1NXDA RN Radioiodinated CGP 42112A: a novel high affinity and highly selective ligand for the characterization of angiotensin AT2 receptors. Biochem Biophys Res Commun. 1991 Dec 31;181(3):1365-71. DM1NXDA RU https://pubmed.ncbi.nlm.nih.gov/1764088 DMEPT8H DI DMEPT8H DMEPT8H DN [125I]DIV880 DMEPT8H MI TT0WAIE DMEPT8H MN Melatonin receptor type 1A (MTNR1A) DMEPT8H MT DTT DMEPT8H MA Agonist DMEPT8H RN New radioligands for describing the molecular pharmacology of MT1 and MT2 melatonin receptors. Int J Mol Sci. 2013 Apr 25;14(5):8948-62. DMEPT8H RU https://pubmed.ncbi.nlm.nih.gov/23698757 DMQUY08 DI DMQUY08 DMQUY08 DN [125I]DOI DMQUY08 MI TTJQOD7 DMQUY08 MN 5-HT 2A receptor (HTR2A) DMQUY08 MT DTT DMQUY08 MA Agonist DMQUY08 RN Effect of ring fluorination on the pharmacology of hallucinogenic tryptamines. J Med Chem. 2000 Nov 30;43(24):4701-10. DMQUY08 RU https://pubmed.ncbi.nlm.nih.gov/11101361 DMQUY08 DI DMQUY08 DMQUY08 DN [125I]DOI DMQUY08 MI TT0K1SC DMQUY08 MN 5-HT 2B receptor (HTR2B) DMQUY08 MT DTT DMQUY08 MA Agonist DMQUY08 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 7). DMQUY08 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=7 DMQUY08 DI DMQUY08 DMQUY08 DN [125I]DOI DMQUY08 MI TTWJBZ5 DMQUY08 MN 5-HT 2C receptor (HTR2C) DMQUY08 MT DTT DMQUY08 MA Agonist DMQUY08 RN High-affinity agonist binding correlates with efficacy (intrinsic activity) at the human serotonin 5-HT2A and 5-HT2C receptors: evidence favoring the ternary complex and two-state models of agonist action. J Neurochem. 1999 May;72(5):2127-34. DMQUY08 RU https://pubmed.ncbi.nlm.nih.gov/10217294 DMZWQH3 DI DMZWQH3 DMZWQH3 DN [125I]epibatidine DMZWQH3 MI TTH18TF DMZWQH3 MN Muscarinic acetylcholine receptor M5 (CHRM5) DMZWQH3 MT DTT DMZWQH3 MA Agonist DMZWQH3 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 467). DMZWQH3 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=467 DMZWQH3 DI DMZWQH3 DMZWQH3 DN [125I]epibatidine DMZWQH3 MI TTF4E0J DMZWQH3 MN Neuronal acetylcholine receptor alpha-2 (CHRNA2) DMZWQH3 MT DTT DMZWQH3 MA Agonist DMZWQH3 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 463). DMZWQH3 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=463 DMZWQH3 DI DMZWQH3 DMZWQH3 DN [125I]epibatidine DMZWQH3 MI TTLA931 DMZWQH3 MN Neuronal acetylcholine receptor alpha-7 (CHRNA7) DMZWQH3 MT DTT DMZWQH3 MA Agonist DMZWQH3 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 468). DMZWQH3 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=468 DMZWQH3 DI DMZWQH3 DMZWQH3 DN [125I]epibatidine DMZWQH3 MI TT5KPZR DMZWQH3 MN Neuronal acetylcholine receptor beta-2 (CHRNB2) DMZWQH3 MT DTT DMZWQH3 MA Agonist DMZWQH3 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 465). DMZWQH3 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=465 DMEKGZS DI DMEKGZS DMEKGZS DN [125I]EXP985 DMEKGZS MI TT8DBY3 DMEKGZS MN Angiotensin II receptor type-1 (AGTR1) DMEKGZS MT DTT DMEKGZS MA Antagonist DMEKGZS RN [125I]EXP985: a highly potent and specific nonpeptide radioligand antagonist for the AT1 angiotensin receptor. Biochem Biophys Res Commun. 1992 Nov 16;188(3):1030-9. DMEKGZS RU https://pubmed.ncbi.nlm.nih.gov/1445340 DMFWE4H DI DMFWE4H DMFWE4H DN [125I]GR231118 DMFWE4H MI TTRK9JT DMFWE4H MN Neuropeptide Y receptor type 1 (NPY1R) DMFWE4H MT DTT DMFWE4H MA Antagonist DMFWE4H RN [(125)I]-GR231118: a high affinity radioligand to investigate neuropeptide Y Y(1) and Y(4) receptors. Br J Pharmacol. 2000 Jan;129(1):37-46. DMFWE4H RU https://pubmed.ncbi.nlm.nih.gov/10694200 DMFWE4H DI DMFWE4H DMFWE4H DN [125I]GR231118 DMFWE4H MI TTW4N16 DMFWE4H MN Neuropeptide Y receptor type 4 (NPY4R) DMFWE4H MT DTT DMFWE4H MA Agonist DMFWE4H RN [(125)I]-GR231118: a high affinity radioligand to investigate neuropeptide Y Y(1) and Y(4) receptors. Br J Pharmacol. 2000 Jan;129(1):37-46. DMFWE4H RU https://pubmed.ncbi.nlm.nih.gov/10694200 DMSYT5P DI DMSYT5P DMSYT5P DN [125I]GTI DMSYT5P MI TTK8CXU DMSYT5P MN 5-HT 1B receptor (HTR1B) DMSYT5P MT DTT DMSYT5P MA Agonist DMSYT5P RN Autoradiographic characterisation and localisation of 5-HT1D compared to 5-HT1B binding sites in rat brain. Naunyn Schmiedebergs Arch Pharmacol. 1993 Jun;347(6):569-82. DMSYT5P RU https://pubmed.ncbi.nlm.nih.gov/8361548 DMSYT5P DI DMSYT5P DMSYT5P DN [125I]GTI DMSYT5P MI TT6MSOK DMSYT5P MN 5-HT 1D receptor (HTR1D) DMSYT5P MT DTT DMSYT5P MA Agonist DMSYT5P RN Autoradiographic characterisation and localisation of 5-HT1D compared to 5-HT1B binding sites in rat brain. Naunyn Schmiedebergs Arch Pharmacol. 1993 Jun;347(6):569-82. DMSYT5P RU https://pubmed.ncbi.nlm.nih.gov/8361548 DMTFP5Q DI DMTFP5Q DMTFP5Q DN [125I]HEAT DMTFP5Q MI TTBRKXS DMTFP5Q MN Adrenergic receptor alpha-1B (ADRA1B) DMTFP5Q MT DTT DMTFP5Q MA Agonist DMTFP5Q RN KMD-3213, a novel, potent, alpha 1a-adrenoceptor-selective antagonist: characterization using recombinant human alpha 1-adrenoceptors and native tissues. Mol Pharmacol. 1995 Aug;48(2):250-8. DMTFP5Q RU https://pubmed.ncbi.nlm.nih.gov/7651358 DMTFP5Q DI DMTFP5Q DMTFP5Q DN [125I]HEAT DMTFP5Q MI TT2NUT5 DMTFP5Q MN Adrenergic receptor alpha-2C (ADRA2C) DMTFP5Q MT DTT DMTFP5Q MA Agonist DMTFP5Q RN KMD-3213, a novel, potent, alpha 1a-adrenoceptor-selective antagonist: characterization using recombinant human alpha 1-adrenoceptors and native tissues. Mol Pharmacol. 1995 Aug;48(2):250-8. DMTFP5Q RU https://pubmed.ncbi.nlm.nih.gov/7651358 DM3BQHO DI DM3BQHO DM3BQHO DN [125I]ICYP DM3BQHO MI TTMXGCW DM3BQHO MN Adrenergic receptor beta-3 (ADRB3) DM3BQHO MT DTT DM3BQHO MA Agonist DM3BQHO RN Stereoselectivity for interactions of agonists and antagonists at mouse, rat and human beta3-adrenoceptors. Eur J Pharmacol. 2004 Jan 26;484(2-3):323-31. DM3BQHO RU https://pubmed.ncbi.nlm.nih.gov/14744619 DMHJL58 DI DMHJL58 DMHJL58 DN [125I]iodoaminopotentidine DMHJL58 MI TTQHJ1K DMHJL58 MN Histamine H2 receptor (H2R) DMHJL58 MT DTT DMHJL58 MA Antagonist DMHJL58 RN G proteins of the Gq family couple the H2 histamine receptor to phospholipase C. Mol Endocrinol. 1996 Dec;10(12):1697-707. DMHJL58 RU https://pubmed.ncbi.nlm.nih.gov/8961278 DMN4ABU DI DMN4ABU DMN4ABU DN [125I]iodophenpropit DMN4ABU MI TT9JNIC DMN4ABU MN Histamine H3 receptor (H3R) DMN4ABU MT DTT DMN4ABU MA Antagonist DMN4ABU RN Characterization of the binding of the first selective radiolabelled histamine H3-receptor antagonist, [125I]-iodophenpropit, to rat brain. Br J Pharmacol. 1994 Oct;113(2):355-62. DMN4ABU RU https://pubmed.ncbi.nlm.nih.gov/7834183 DMN4ABU DI DMN4ABU DMN4ABU DN [125I]iodophenpropit DMN4ABU MI TTXJ178 DMN4ABU MN Histamine H4 receptor (H4R) DMN4ABU MT DTT DMN4ABU MA Inhibitor DMN4ABU RN Discovery of novel human histamine H4 receptor ligands by large-scale structure-based virtual screening. J Med Chem. 2008 Jun 12;51(11):3145-53. DMN4ABU RU https://pubmed.ncbi.nlm.nih.gov/18459760 DMVEHI7 DI DMVEHI7 DMVEHI7 DN [125I]IRL1620 DMVEHI7 MI TT3ZTGU DMVEHI7 MN Endothelin B receptor (EDNRB) DMVEHI7 MT DTT DMVEHI7 MA Agonist DMVEHI7 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 220). DMVEHI7 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=220 DMKSI80 DI DMKSI80 DMKSI80 DN [125I]L703,606 DMKSI80 MI TTZPO1L DMKSI80 MN Substance-P receptor (TACR1) DMKSI80 MT DTT DMKSI80 MA Antagonist DMKSI80 RN Radioiodinated L-703,606: a potent, selective antagonist to the human NK1 receptor. Appl Radiat Isot. 1994 Jan;45(1):97-103. DMKSI80 RU https://pubmed.ncbi.nlm.nih.gov/8287060 DMO7VRJ DI DMO7VRJ DMO7VRJ DN [125I]L750667 DMO7VRJ MI TTE0A2F DMO7VRJ MN Dopamine D4 receptor (D4R) DMO7VRJ MT DTT DMO7VRJ MA Antagonist DMO7VRJ RN Identification and pharmacological characterization of [125I]L-750,667, a novel radioligand for the dopamine D4 receptor. Mol Pharmacol. 1996 Dec;50(6):1658-64. DMO7VRJ RU https://pubmed.ncbi.nlm.nih.gov/8967990 DMP69QG DI DMP69QG DMP69QG DN [125I]LSD DMP69QG MI TT0MI3F DMP69QG MN 5-HT 1F receptor (HTR1F) DMP69QG MT DTT DMP69QG MA Agonist DMP69QG RN Isolation of a mouse "5HT1E-like" serotonin receptor expressed predominantly in hippocampus. J Biol Chem. 1992 Oct 5;267(28):19761-4. DMP69QG RU https://pubmed.ncbi.nlm.nih.gov/1328180 DMP69QG DI DMP69QG DMP69QG DN [125I]LSD DMP69QG MI TTRUFDT DMP69QG MN 5-HT 5A receptor (HTR5A) DMP69QG MT DTT DMP69QG MA Agonist DMP69QG RN Human 5-HT(5) receptors: the 5-HT(5A) receptor is functional but the 5-HT(5B) receptor was lost during mammalian evolution. Eur J Pharmacol. 2001 Apr 27;418(3):157-67. DMP69QG RU https://pubmed.ncbi.nlm.nih.gov/11343685 DMP69QG DI DMP69QG DMP69QG DN [125I]LSD DMP69QG MI TT9KJ1X DMP69QG MN 5-HT 5B receptor (HTR5B) DMP69QG MT DTT DMP69QG MA Agonist DMP69QG RN Mouse 5-hydroxytryptamine5A and 5-hydroxytryptamine5B receptors define a new family of serotonin receptors: cloning, functional expression, and chromosomal localization. Mol Pharmacol. 1993 Mar;43(3):313-9. DMP69QG RU https://pubmed.ncbi.nlm.nih.gov/8450829 DMP69QG DI DMP69QG DMP69QG DN [125I]LSD DMP69QG MI TTO9X1H DMP69QG MN 5-HT 7 receptor (HTR7) DMP69QG MT DTT DMP69QG MA Agonist DMP69QG RN A novel adenylyl cyclase-activating serotonin receptor (5-HT7) implicated in the regulation of mammalian circadian rhythms. Neuron. 1993 Sep;11(3):449-58. DMP69QG RU https://pubmed.ncbi.nlm.nih.gov/8398139 DMEHK9M DI DMEHK9M DMEHK9M DN [125I]PD142308 DMEHK9M MI TTVFO0U DMEHK9M MN Gastrin/cholecystokinin type B receptor (CCKBR) DMEHK9M MT DTT DMEHK9M MA Antagonist DMEHK9M RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 77). DMEHK9M RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=77 DM4HLO5 DI DM4HLO5 DM4HLO5 DN [125I]PD151242 DM4HLO5 MI TTKRD0G DM4HLO5 MN Endothelin A receptor (EDNRA) DM4HLO5 MT DTT DM4HLO5 MA Antagonist DM4HLO5 RN [125I]-PD151242: a selective radioligand for human ETA receptors. Br J Pharmacol. 1994 Jan;111(1):4-6. DM4HLO5 RU https://pubmed.ncbi.nlm.nih.gov/8012722 DMROKJP DI DMROKJP DMROKJP DN [125I]PTA-OH DMROKJP MI TT2O84V DMROKJP MN Thromboxane A2 receptor (TBXA2R) DMROKJP MT DTT DMROKJP MA Antagonist DMROKJP RN Binding of thromboxane A2/prostaglandin H2 agonists to human platelets. Br J Pharmacol. 1987 May;91(1):223-7. DMROKJP RU https://pubmed.ncbi.nlm.nih.gov/3594077 DMUD3A8 DI DMUD3A8 DMUD3A8 DN [125I]resiniferatoxin DMUD3A8 MI TTMI6F5 DMUD3A8 MN Transient receptor potential cation channel V1 (TRPV1) DMUD3A8 MT DTT DMUD3A8 MA Blocker (channel blocker) DMUD3A8 RN Iodo-resiniferatoxin, a new potent vanilloid receptor antagonist. Mol Pharmacol. 2001 Jan;59(1):9-15. DMUD3A8 RU https://pubmed.ncbi.nlm.nih.gov/11125018 DMHC6KX DI DMHC6KX DMHC6KX DN [125I]S70254 DMHC6KX MI TT0WAIE DMHC6KX MN Melatonin receptor type 1A (MTNR1A) DMHC6KX MT DTT DMHC6KX MA Agonist DMHC6KX RN New radioligands for describing the molecular pharmacology of MT1 and MT2 melatonin receptors. Int J Mol Sci. 2013 Apr 25;14(5):8948-62. DMHC6KX RU https://pubmed.ncbi.nlm.nih.gov/23698757 DM1DXHG DI DM1DXHG DM1DXHG DN [125I]SAP DM1DXHG MI TT2O84V DM1DXHG MN Thromboxane A2 receptor (TBXA2R) DM1DXHG MT DTT DM1DXHG MA Antagonist DM1DXHG RN 7-[(1R,2S,3S,5R)-6,6-dimethyl-3-(4- iodobenzenesulfonylamino)bicyclo[3.1.1]hept-2-yl]-5(Z)-heptenoic acid: a novel high-affinity radiolabeled antagonist for platelet thromboxane A2/prostaglandin H2 receptors. J Pharmacol Exp Ther. 1992 Aug;262(2):632-7. DM1DXHG RU https://pubmed.ncbi.nlm.nih.gov/1386885 DM0XUPK DI DM0XUPK DM0XUPK DN [125I]SB-236636 DM0XUPK MI TTT2SVW DM0XUPK MN PPAR-gamma messenger RNA (PPARG mRNA) DM0XUPK MT DTT DM0XUPK MA Agonist DM0XUPK RN Identification of high-affinity binding sites for the insulin sensitizer rosiglitazone (BRL-49653) in rodent and human adipocytes using a radioiodinated ligand for peroxisomal proliferator-activated receptor gamma. J Pharmacol Exp Ther. 1998 Feb;284(2):751-9. DM0XUPK RU https://pubmed.ncbi.nlm.nih.gov/9454824 DMXWZCB DI DMXWZCB DMXWZCB DN [125I]SB-258585 DMXWZCB MI TTJS8PY DMXWZCB MN 5-HT 6 receptor (HTR6) DMXWZCB MT DTT DMXWZCB MA Antagonist DMXWZCB RN 5-HT6 receptor binding sites in schizophrenia and following antipsychotic drug administration: autoradiographic studies with [125I]SB-258585. Synapse. 2002 Sep 1;45(3):191-9. DMXWZCB RU https://pubmed.ncbi.nlm.nih.gov/12112397 DM06S9X DI DM06S9X DM06S9X DN [125I]SCH23982 DM06S9X MI TTZFYLI DM06S9X MN Dopamine D1 receptor (D1R) DM06S9X MT DTT DM06S9X MA Antagonist DM06S9X RN Molecular cloning and expression of the gene for a human D1 dopamine receptor. Nature. 1990 Sep 6;347(6288):72-6. DM06S9X RU https://pubmed.ncbi.nlm.nih.gov/2144334 DM06S9X DI DM06S9X DM06S9X DN [125I]SCH23982 DM06S9X MI TTS2PH3 DM06S9X MN Dopamine D5 receptor (D5R) DM06S9X MT DTT DM06S9X MA Antagonist DM06S9X RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 218). DM06S9X RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=218 DM285MQ DI DM285MQ DM285MQ DN [125I]SD6 DM285MQ MI TT0WAIE DM285MQ MN Melatonin receptor type 1A (MTNR1A) DM285MQ MT DTT DM285MQ MA Agonist DM285MQ RN New radioligands for describing the molecular pharmacology of MT1 and MT2 melatonin receptors. Int J Mol Sci. 2013 Apr 25;14(5):8948-62. DM285MQ RU https://pubmed.ncbi.nlm.nih.gov/23698757 DM0GKMA DI DM0GKMA DM0GKMA DN [125I]SQ-29548 DM0GKMA MI TT2O84V DM0GKMA MN Thromboxane A2 receptor (TBXA2R) DM0GKMA MT DTT DM0GKMA MA Antagonist DM0GKMA RN Characterization of [5,6-3H]SQ 29,548 as a high affinity radioligand, binding to thromboxane A2/prostaglandin H2-receptors in human platelets. J Pharmacol Exp Ther. 1988 Jun;245(3):786-92. DM0GKMA RU https://pubmed.ncbi.nlm.nih.gov/2968449 DME53D6 DI DME53D6 DME53D6 DN [125I]ZM-241385 DME53D6 MI TTNE7KG DME53D6 MN Adenosine A2b receptor (ADORA2B) DME53D6 MT DTT DME53D6 MA Antagonist DME53D6 RN 125I-4-(2-[7-amino-2-[2-furyl][1,2,4]triazolo[2,3-a][1,3,5] triazin-5-yl-amino]ethyl)phenol, a high affinity antagonist radioligand selective for the A2a adenosine receptor. Mol Pharmacol. 1995 Dec;48(6):970-4. DME53D6 RU https://pubmed.ncbi.nlm.nih.gov/8848012 DM42B5D DI DM42B5D DM42B5D DN [14C]acetylCoA DM42B5D MI TTLJKZ0 DM42B5D MN Acetyl-CoA transporter (SLC33A1) DM42B5D MT DTT DM42B5D MA Modulator DM42B5D RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1134). DM42B5D RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1134 DMGLQ72 DI DMGLQ72 DMGLQ72 DN [14C]GlySar DMGLQ72 MI TT5LF3C DMGLQ72 MN Solute carrier family 15 member 1 (SLC15A1) DMGLQ72 MT DTT DMGLQ72 MA Modulator DMGLQ72 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 984). DMGLQ72 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=984 DMGLQ72 DI DMGLQ72 DMGLQ72 DN [14C]GlySar DMGLQ72 MI TT27Q3A DMGLQ72 MN Solute carrier family 15 member 2 (SLC15A2) DMGLQ72 MT DTT DMGLQ72 MA Modulator DMGLQ72 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 985). DMGLQ72 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=985 DMVUF71 DI DMVUF71 DMVUF71 DN [14C]histidine DMVUF71 MI TTAYPWS DMVUF71 MN Solute carrier family 15 member 3 (SLC15A3) DMVUF71 MT DTT DMVUF71 MA Modulator DMVUF71 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 986). DMVUF71 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=986 DMVUF71 DI DMVUF71 DMVUF71 DN [14C]histidine DMVUF71 MI TTG2XRE DMVUF71 MN Solute carrier family 15 member 4 (SLC15A4) DMVUF71 MT DTT DMVUF71 MA Modulator DMVUF71 RN Cloning and functional expression of a brain peptide/histidine transporter. J Biol Chem. 1997 Apr 11;272(15):10205-11. DMVUF71 RU https://pubmed.ncbi.nlm.nih.gov/9092568 DMVUF71 DI DMVUF71 DMVUF71 DN [14C]histidine DMVUF71 MI TTC8YPT DMVUF71 MN Solute carrier family 38 member 5 (SLC38A5) DMVUF71 MT DTT DMVUF71 MA Modulator DMVUF71 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1173). DMVUF71 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1173 DMRBZ3X DI DMRBZ3X DMRBZ3X DN [14C]methylamine DMRBZ3X MI TTVHFE8 DMRBZ3X MN Ammonium transporter Rh type A (RHAG) DMRBZ3X MT DTT DMRBZ3X MA Modulator DMRBZ3X RN The Rh complex exports ammonium from human red blood cells. Br J Haematol. 2003 Jul;122(2):333-40. DMRBZ3X RU https://pubmed.ncbi.nlm.nih.gov/12846905 DMRBZ3X DI DMRBZ3X DMRBZ3X DN [14C]methylamine DMRBZ3X MI TTN5MZ3 DMRBZ3X MN Ammonium transporter Rh type C (RHCG) DMRBZ3X MT DTT DMRBZ3X MA Modulator DMRBZ3X RN Characterization of ammonia transport by the kidney Rh glycoproteins RhBG and RhCG. Am J Physiol Renal Physiol. 2006 Feb;290(2):F297-305. DMRBZ3X RU https://pubmed.ncbi.nlm.nih.gov/16131648 DMG17IU DI DMG17IU DMG17IU DN [14C]MTEP DMG17IU MI TTHS256 DMG17IU MN Metabotropic glutamate receptor 5 (mGluR5) DMG17IU MT DTT DMG17IU MA Modulator (allosteric modulator) DMG17IU RN [3H]Methoxymethyl-3-[(2-methyl-1,3-thiazol-4-yl)ethynyl]pyridine binding to metabotropic glutamate receptor subtype 5 in rodent brain: in vitro and in vivo characterization. J Pharmacol Exp Ther. 2002 Dec;303(3):1044-51. DMG17IU RU https://pubmed.ncbi.nlm.nih.gov/12438526 DM6SFYH DI DM6SFYH DM6SFYH DN [14C]TEA DM6SFYH MI TTSF1KH DM6SFYH MN Aquaporin-1 (AQP1) DM6SFYH MT DTT DM6SFYH MA Inhibitor DM6SFYH RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 688). DM6SFYH RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=688 DM6SFYH DI DM6SFYH DM6SFYH DN [14C]TEA DM6SFYH MI TT9R6BE DM6SFYH MN Calcium-activated potassium channel KCa2.1 (KCNN1) DM6SFYH MT DTT DM6SFYH MA Blocker (channel blocker) DM6SFYH RN Small conductance calcium-activated potassium channels: from structure to function. Prog Neurobiol. 2010 Jul;91(3):242-55. DM6SFYH RU https://pubmed.ncbi.nlm.nih.gov/20359520 DM6SFYH DI DM6SFYH DM6SFYH DN [14C]TEA DM6SFYH MI TT2T5M0 DM6SFYH MN Calcium-activated potassium channel KCa2.2 (KCNN2) DM6SFYH MT DTT DM6SFYH MA Blocker (channel blocker) DM6SFYH RN Small conductance calcium-activated potassium channels: from structure to function. Prog Neurobiol. 2010 Jul;91(3):242-55. DM6SFYH RU https://pubmed.ncbi.nlm.nih.gov/20359520 DM6SFYH DI DM6SFYH DM6SFYH DN [14C]TEA DM6SFYH MI TT9JH25 DM6SFYH MN Calcium-activated potassium channel KCa2.3 (KCNN3) DM6SFYH MT DTT DM6SFYH MA Blocker (channel blocker) DM6SFYH RN Small conductance calcium-activated potassium channels: from structure to function. Prog Neurobiol. 2010 Jul;91(3):242-55. DM6SFYH RU https://pubmed.ncbi.nlm.nih.gov/20359520 DM6SFYH DI DM6SFYH DM6SFYH DN [14C]TEA DM6SFYH MI TTGJFK1 DM6SFYH MN Calcium-activated potassium channel KCa4.1 (KCNT1) DM6SFYH MT DTT DM6SFYH MA Blocker (channel blocker) DM6SFYH RN For K+ channels, Na+ is the new Ca2+. Trends Neurosci. 2005 Aug;28(8):422-8. DM6SFYH RU https://pubmed.ncbi.nlm.nih.gov/15979166 DM6SFYH DI DM6SFYH DM6SFYH DN [14C]TEA DM6SFYH MI TTLU5FO DM6SFYH MN Calcium-activated potassium channel KCa4.2 (KCNT2) DM6SFYH MT DTT DM6SFYH MA Blocker (channel blocker) DM6SFYH RN Opposite regulation of Slick and Slack K+ channels by neuromodulators. J Neurosci. 2006 May 10;26(19):5059-68. DM6SFYH RU https://pubmed.ncbi.nlm.nih.gov/16687497 DM6SFYH DI DM6SFYH DM6SFYH DN [14C]TEA DM6SFYH MI TTI9XK6 DM6SFYH MN Calcium-activated potassium channel KCa5.1 (KCNU1) DM6SFYH MT DTT DM6SFYH MA Blocker (channel blocker) DM6SFYH RN Block of mouse Slo1 and Slo3 K+ channels by CTX, IbTX, TEA, 4-AP and quinidine. Channels (Austin). 2010 Jan-Feb;4(1):22-41. DM6SFYH RU https://pubmed.ncbi.nlm.nih.gov/19934650 DM6SFYH DI DM6SFYH DM6SFYH DN [14C]TEA DM6SFYH MI TT1AQ50 DM6SFYH MN Charybdotoxin receptor beta-4 (BKbeta4) DM6SFYH MT DTT DM6SFYH MA Inhibitor DM6SFYH RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 380). DM6SFYH RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=380 DM6SFYH DI DM6SFYH DM6SFYH DN [14C]TEA DM6SFYH MI TTXF0ZW DM6SFYH MN Inward rectifier potassium channel Kir2.3 (KCNJ4) DM6SFYH MT DTT DM6SFYH MA Blocker (channel blocker) DM6SFYH RN Cloning and expression of a novel human brain inward rectifier potassium channel. J Biol Chem. 1994 Aug 12;269(32):20468-74. DM6SFYH RU https://pubmed.ncbi.nlm.nih.gov/8051145 DM6SFYH DI DM6SFYH DM6SFYH DN [14C]TEA DM6SFYH MI DTZGT0P DM6SFYH MN Multidrug and toxin extrusion protein 1 (SLC47A1) DM6SFYH MT DTP DM6SFYH MA Substrate DM6SFYH RN A human transporter protein that mediates the final excretion step for toxic organic cations. Proc Natl Acad Sci U S A. 2005 Dec 13;102(50):17923-8. DM6SFYH RU http://www.ncbi.nlm.nih.gov/pubmed/16330770 DM6SFYH DI DM6SFYH DM6SFYH DN [14C]TEA DM6SFYH MI TT7HXSL DM6SFYH MN Multidrug and toxin extrusion protein 2 (MATE2) DM6SFYH MT DTT DM6SFYH MA Modulator DM6SFYH RN Substrate specificity of MATE1 and MATE2-K, human multidrug and toxin extrusions/H(+)-organic cation antiporters. Biochem Pharmacol. 2007 Jul 15;74(2):359-71. DM6SFYH RU https://pubmed.ncbi.nlm.nih.gov/17509534 DM6SFYH DI DM6SFYH DM6SFYH DN [14C]TEA DM6SFYH MI DT3TX4H DM6SFYH MN Multidrug and toxin extrusion protein 2 (SLC47A2) DM6SFYH MT DTP DM6SFYH MA Substrate DM6SFYH RN Substrate specificity of MATE1 and MATE2-K, human multidrug and toxin extrusions/H(+)-organic cation antiporters. Biochem Pharmacol. 2007 Jul 15;74(2):359-71. DM6SFYH RU http://www.ncbi.nlm.nih.gov/pubmed/17509534 DM6SFYH DI DM6SFYH DM6SFYH DN [14C]TEA DM6SFYH MI DTT79CX DM6SFYH MN Organic cation transporter 1 (SLC22A1) DM6SFYH MT DTP DM6SFYH MA Substrate DM6SFYH RN Involvement of human organic cation transporter 1 in the hepatic uptake of 1-(2-methoxyethyl)-2-methyl-4,9-dioxo-3-(pyrazin-2-ylmethyl)-4,9-dihydro-1H-naphtho[2,3-d]imidazolium bromide (YM155 monobromide), a novel, small molecule survivin suppressant. Drug Metab Dispos. 2009 Sep;37(9):1856-63. DM6SFYH RU http://www.ncbi.nlm.nih.gov/pubmed/19520775 DM6SFYH DI DM6SFYH DM6SFYH DN [14C]TEA DM6SFYH MI DT9IDPW DM6SFYH MN Organic cation transporter 2 (SLC22A2) DM6SFYH MT DTP DM6SFYH MA Substrate DM6SFYH RN Molecular mechanisms of organic cation transport in OCT2-expressing Xenopus oocytes. Biochim Biophys Acta. 1999 Mar 4;1417(2):224-31. DM6SFYH RU http://www.ncbi.nlm.nih.gov/pubmed/10082798 DM6SFYH DI DM6SFYH DM6SFYH DN [14C]TEA DM6SFYH MI DT2EG60 DM6SFYH MN Organic cation/carnitine transporter 1 (SLC22A4) DM6SFYH MT DTP DM6SFYH MA Substrate DM6SFYH RN Functional effects of protein sequence polymorphisms in the organic cation/ergothioneine transporter OCTN1 (SLC22A4). Pharmacogenet Genomics. 2007 Sep;17(9):773-82. DM6SFYH RU http://www.ncbi.nlm.nih.gov/pubmed/17700366 DM6SFYH DI DM6SFYH DM6SFYH DN [14C]TEA DM6SFYH MI TTMHCGA DM6SFYH MN Solute carrier family 47 member 1 (SLC47A1) DM6SFYH MT DTT DM6SFYH MA Modulator DM6SFYH RN Molecular cloning, functional characterization and tissue distribution of rat H+/organic cation antiporter MATE1. Pharm Res. 2006 Aug;23(8):1696-701. DM6SFYH RU https://pubmed.ncbi.nlm.nih.gov/16850272 DM6SFYH DI DM6SFYH DM6SFYH DN [14C]TEA DM6SFYH MI TTBECWA DM6SFYH MN Transient receptor potential cation channel V2 (TRPV2) DM6SFYH MT DTT DM6SFYH MA Blocker (channel blocker) DM6SFYH RN Pharmacological characterization and molecular determinants of the activation of transient receptor potential V2 channel orthologs by 2-aminoethoxy... Mol Pharmacol. 2007 Nov;72(5):1258-68. DM6SFYH RU https://pubmed.ncbi.nlm.nih.gov/17673572 DM6SFYH DI DM6SFYH DM6SFYH DN [14C]TEA DM6SFYH MI TTS3DIK DM6SFYH MN Voltage-gated potassium channel Kv1.1 (KCNA1) DM6SFYH MT DTT DM6SFYH MA Blocker (channel blocker) DM6SFYH RN Pharmacological characterization of five cloned voltage-gated K+ channels, types Kv1.1, 1.2, 1.3, 1.5, and 3.1, stably expressed in mammalian cell lines. Mol Pharmacol. 1994 Jun;45(6):1227-34. DM6SFYH RU https://pubmed.ncbi.nlm.nih.gov/7517498 DM6SFYH DI DM6SFYH DM6SFYH DN [14C]TEA DM6SFYH MI TTVFB0O DM6SFYH MN Voltage-gated potassium channel Kv1.2 (KCNA2) DM6SFYH MT DTT DM6SFYH MA Blocker (channel blocker) DM6SFYH RN Pharmacological characterization of five cloned voltage-gated K+ channels, types Kv1.1, 1.2, 1.3, 1.5, and 3.1, stably expressed in mammalian cell lines. Mol Pharmacol. 1994 Jun;45(6):1227-34. DM6SFYH RU https://pubmed.ncbi.nlm.nih.gov/7517498 DM6SFYH DI DM6SFYH DM6SFYH DN [14C]TEA DM6SFYH MI TTY3UE6 DM6SFYH MN Voltage-gated potassium channel Kv1.3 (KCNA3) DM6SFYH MT DTT DM6SFYH MA Blocker (channel blocker) DM6SFYH RN Pharmacological characterization of five cloned voltage-gated K+ channels, types Kv1.1, 1.2, 1.3, 1.5, and 3.1, stably expressed in mammalian cell lines. Mol Pharmacol. 1994 Jun;45(6):1227-34. DM6SFYH RU https://pubmed.ncbi.nlm.nih.gov/7517498 DM6SFYH DI DM6SFYH DM6SFYH DN [14C]TEA DM6SFYH MI TTW0CMT DM6SFYH MN Voltage-gated potassium channel Kv1.5 (KCNA5) DM6SFYH MT DTT DM6SFYH MA Blocker (channel blocker) DM6SFYH RN Pharmacological characterization of five cloned voltage-gated K+ channels, types Kv1.1, 1.2, 1.3, 1.5, and 3.1, stably expressed in mammalian cell lines. Mol Pharmacol. 1994 Jun;45(6):1227-34. DM6SFYH RU https://pubmed.ncbi.nlm.nih.gov/7517498 DM6SFYH DI DM6SFYH DM6SFYH DN [14C]TEA DM6SFYH MI TTJ2W69 DM6SFYH MN Voltage-gated potassium channel Kv1.6 (KCNA6) DM6SFYH MT DTT DM6SFYH MA Blocker (channel blocker) DM6SFYH RN Cloning and expression of a human voltage-gated potassium channel. A novel member of the RCK potassium channel family. EMBO J. 1990 Jun;9(6):1749-56. DM6SFYH RU https://pubmed.ncbi.nlm.nih.gov/2347305 DM6SFYH DI DM6SFYH DM6SFYH DN [14C]TEA DM6SFYH MI TTCVBT7 DM6SFYH MN Voltage-gated potassium channel Kv1.7 (KCNA7) DM6SFYH MT DTT DM6SFYH MA Blocker (channel blocker) DM6SFYH RN Characterisation of the human voltage-gated potassium channel gene, KCNA7, a candidate gene for inherited cardiac disorders, and its exclusion as cause of progressive familial heart block I (PFHBI). Eur J Hum Genet. 2002 Jan;10(1):36-43. DM6SFYH RU https://pubmed.ncbi.nlm.nih.gov/11896454 DM6SFYH DI DM6SFYH DM6SFYH DN [14C]TEA DM6SFYH MI TTT4Y0X DM6SFYH MN Voltage-gated potassium channel Kv1.8 (KCNA10) DM6SFYH MT DTT DM6SFYH MA Blocker (channel blocker) DM6SFYH RN KCNA10: a novel ion channel functionally related to both voltage-gated potassium and CNG cation channels. Am J Physiol Renal Physiol. 2000 Jun;278(6):F1013-21. DM6SFYH RU https://pubmed.ncbi.nlm.nih.gov/10836990 DM6SFYH DI DM6SFYH DM6SFYH DN [14C]TEA DM6SFYH MI TT5OEKU DM6SFYH MN Voltage-gated potassium channel Kv2.1 (KCNB1) DM6SFYH MT DTT DM6SFYH MA Blocker (channel blocker) DM6SFYH RN Modulation of Kv2.1 channel gating and TEA sensitivity by distinct domains of SNAP-25. Biochem J. 2006 Jun 1;396(2):363-9. DM6SFYH RU https://pubmed.ncbi.nlm.nih.gov/16478442 DM6SFYH DI DM6SFYH DM6SFYH DN [14C]TEA DM6SFYH MI TT5PFNG DM6SFYH MN Voltage-gated potassium channel Kv2.2 (KCNB2) DM6SFYH MT DTT DM6SFYH MA Blocker (channel blocker) DM6SFYH RN Molecular identification of a component of delayed rectifier current in gastrointestinal smooth muscles. Am J Physiol. 1998 May;274(5 Pt 1):G901-11. DM6SFYH RU https://pubmed.ncbi.nlm.nih.gov/9612272 DM6SFYH DI DM6SFYH DM6SFYH DN [14C]TEA DM6SFYH MI TTVUWHQ DM6SFYH MN Voltage-gated potassium channel Kv3.1 (KCNC1) DM6SFYH MT DTT DM6SFYH MA Blocker (channel blocker) DM6SFYH RN Pharmacological characterization of five cloned voltage-gated K+ channels, types Kv1.1, 1.2, 1.3, 1.5, and 3.1, stably expressed in mammalian cell lines. Mol Pharmacol. 1994 Jun;45(6):1227-34. DM6SFYH RU https://pubmed.ncbi.nlm.nih.gov/7517498 DM6SFYH DI DM6SFYH DM6SFYH DN [14C]TEA DM6SFYH MI TTGK3ZO DM6SFYH MN Voltage-gated potassium channel Kv3.2 (KCNC2) DM6SFYH MT DTT DM6SFYH MA Blocker (channel blocker) DM6SFYH RN Gating, modulation and subunit composition of voltage-gated K(+) channels in dendritic inhibitory interneurones of rat hippocampus. J Physiol. 2002 Jan 15;538(Pt 2):405-19. DM6SFYH RU https://pubmed.ncbi.nlm.nih.gov/11790809 DM6SFYH DI DM6SFYH DM6SFYH DN [14C]TEA DM6SFYH MI TTALSY9 DM6SFYH MN Voltage-gated potassium channel Kv3.3 (KCNC3) DM6SFYH MT DTT DM6SFYH MA Blocker (channel blocker) DM6SFYH RN Cloning of ShIII (Shaw-like) cDNAs encoding a novel high-voltage-activating, TEA-sensitive, type-A K+ channel. Proc Biol Sci. 1992 Apr 22;248(1321):9-18. DM6SFYH RU https://pubmed.ncbi.nlm.nih.gov/1381835 DM6SFYH DI DM6SFYH DM6SFYH DN [14C]TEA DM6SFYH MI TTODZF1 DM6SFYH MN Voltage-gated potassium channel Kv3.4 (KCNC4) DM6SFYH MT DTT DM6SFYH MA Blocker (channel blocker) DM6SFYH RN Characterization of a Shaw-related potassium channel family in rat brain. EMBO J. 1992 Jul;11(7):2473-86. DM6SFYH RU https://pubmed.ncbi.nlm.nih.gov/1378392 DM6SFYH DI DM6SFYH DM6SFYH DN [14C]TEA DM6SFYH MI TT4DI0J DM6SFYH MN Voltage-gated potassium channel Kv4.1 (KCND1) DM6SFYH MT DTT DM6SFYH MA Blocker (channel blocker) DM6SFYH RN Endogenous Kv channels in human embryonic kidney (HEK-293) cells. Mol Cell Biochem. 2002 Sep;238(1-2):69-79. DM6SFYH RU https://pubmed.ncbi.nlm.nih.gov/12349911 DM6SFYH DI DM6SFYH DM6SFYH DN [14C]TEA DM6SFYH MI TTPXI3S DM6SFYH MN Voltage-gated potassium channel Kv7.2 (KCNQ2) DM6SFYH MT DTT DM6SFYH MA Blocker (channel blocker) DM6SFYH RN Retigabine, a novel anti-convulsant, enhances activation of KCNQ2/Q3 potassium channels. Mol Pharmacol. 2000 Sep;58(3):591-600. DM6SFYH RU https://pubmed.ncbi.nlm.nih.gov/10953053 DM6SFYH DI DM6SFYH DM6SFYH DN [14C]TEA DM6SFYH MI TTIVDM3 DM6SFYH MN Voltage-gated potassium channel Kv7.3 (KCNQ3) DM6SFYH MT DTT DM6SFYH MA Blocker (channel blocker) DM6SFYH RN Differential tetraethylammonium sensitivity of KCNQ1-4 potassium channels. Br J Pharmacol. 2000 Feb;129(3):413-5. DM6SFYH RU https://pubmed.ncbi.nlm.nih.gov/10711337 DM6SFYH DI DM6SFYH DM6SFYH DN [14C]TEA DM6SFYH MI TT8HGRW DM6SFYH MN Voltage-gated potassium channel Kv7.4 (KCNQ4) DM6SFYH MT DTT DM6SFYH MA Blocker (channel blocker) DM6SFYH RN Homomeric and heteromeric assembly of KCNQ (Kv7) K+ channels assayed by total internal reflection fluorescence/fluorescence resonance energy transfer and patch clamp analysis. J Biol Chem. 2008 Nov 7;283(45):30668-76. DM6SFYH RU https://pubmed.ncbi.nlm.nih.gov/18786918 DM6SFYH DI DM6SFYH DM6SFYH DN [14C]TEA DM6SFYH MI TTWVL5Q DM6SFYH MN Voltage-gated potassium channel Kv7.5 (KCNQ5) DM6SFYH MT DTT DM6SFYH MA Blocker (channel blocker) DM6SFYH RN KCNQ5, a novel potassium channel broadly expressed in brain, mediates M-type currents. J Biol Chem. 2000 Aug 4;275(31):24089-95. DM6SFYH RU https://pubmed.ncbi.nlm.nih.gov/10816588 DMZJQC0 DI DMZJQC0 DMZJQC0 DN [18F](R,R)-quinuclidinyl-4-fluoromethyl-benzilate DMZJQC0 MI TTOXS3C DMZJQC0 MN Muscarinic acetylcholine receptor (CHRM) DMZJQC0 MT DTT DMZJQC0 MA Antagonist DMZJQC0 RN In vivo muscarinic binding selectivity of (R,S)- and (R,R)-[18F]-fluoromethyl QNB. Bioorg Med Chem. 1997 Aug;5(8):1555-67. DMZJQC0 RU https://pubmed.ncbi.nlm.nih.gov/9313861 DM65BDN DI DM65BDN DM65BDN DN [18F]altanserin DM65BDN MI TTJQOD7 DM65BDN MN 5-HT 2A receptor (HTR2A) DM65BDN MT DTT DM65BDN MA Antagonist DM65BDN RN Visualisation of loss of 5-HT2A receptors with age in healthy volunteers using [18F]altanserin and positron emission tomographic imaging. Psychiatry Res. 1996 Nov 25;68(1):11-22. DM65BDN RU https://pubmed.ncbi.nlm.nih.gov/9027929 DM4VQNE DI DM4VQNE DM4VQNE DN [18F]FITM DM4VQNE MI TTVBPDM DM4VQNE MN Metabotropic glutamate receptor 1 (mGluR1) DM4VQNE MT DTT DM4VQNE MA Modulator (allosteric modulator) DM4VQNE RN Radiosynthesis and preliminary evaluation of 4-[18F]fluoro-N-[4-[6-(isopropylamino)pyrimidin-4-yl]-1,3-thiazol-2-yl]-N-methylbenzamide as a new positron emission tomography ligand for metabotropic glutamate receptor subtype 1. Bioorg Med Chem Lett. 2011 May 15;21(10):2998-3001. DM4VQNE RU https://pubmed.ncbi.nlm.nih.gov/21470858 DMPWART DI DMPWART DMPWART DN [18F]fluoroethylflumazenil DMPWART MI TTBMV1G DMPWART MN GABA(A) receptor alpha-2 (GABRA2) DMPWART MT DTT DMPWART MA Modulator (allosteric modulator) DMPWART RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 405). DMPWART RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=405 DMPWART DI DMPWART DMPWART DN [18F]fluoroethylflumazenil DMPWART MI TT37EDJ DMPWART MN GABA(A) receptor alpha-3 (GABRA3) DMPWART MT DTT DMPWART MA Modulator (allosteric modulator) DMPWART RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 406). DMPWART RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=406 DMPWART DI DMPWART DMPWART DN [18F]fluoroethylflumazenil DMPWART MI TTNZPQ1 DMPWART MN GABA(A) receptor alpha-5 (GABRA5) DMPWART MT DTT DMPWART MA Modulator (allosteric modulator) DMPWART RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 408). DMPWART RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=408 DMPWART DI DMPWART DMPWART DN [18F]fluoroethylflumazenil DMPWART MI TTEX6LM DMPWART MN GABA(A) receptor gamma-3 (GABRG3) DMPWART MT DTT DMPWART MA Modulator (allosteric modulator) DMPWART RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 415). DMPWART RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=415 DMRQ6XD DI DMRQ6XD DMRQ6XD DN [18F]FPIT DMRQ6XD MI TTVBPDM DMRQ6XD MN Metabotropic glutamate receptor 1 (mGluR1) DMRQ6XD MT DTT DMRQ6XD MA Modulator (allosteric modulator) DMRQ6XD RN Characterization of 1-(2-[18F] fluoro-3-pyridyl)-4-(2-isopropyl-1-oxo- isoindoline-5-yl)-5-methyl-1H-1,2,3-triazole, a PET ligand for imaging the metabotropic glutamate receptor type 1 in rat and monkey brains. J Neurochem. 2012 Apr;121(1):115-24. DMRQ6XD RU https://pubmed.ncbi.nlm.nih.gov/21668889 DMM2YU9 DI DMM2YU9 DMM2YU9 DN [18F]FP-TZTP DMM2YU9 MI TTOXS3C DMM2YU9 MN Muscarinic acetylcholine receptor (CHRM) DMM2YU9 MT DTT DMM2YU9 MA Agonist DMM2YU9 RN Regional brain uptake of the muscarinic ligand, [18F]FP-TZTP, is greatly decreased in M2 receptor knockout mice but not in M1, M3 and M4 receptor knockout mice. Neuropharmacology. 2003 Apr;44(5):653-61. DMM2YU9 RU https://pubmed.ncbi.nlm.nih.gov/12668051 DMQ6AR5 DI DMQ6AR5 DMQ6AR5 DN [18F]MK-1312 DMQ6AR5 MI TTVBPDM DMQ6AR5 MN Metabotropic glutamate receptor 1 (mGluR1) DMQ6AR5 MT DTT DMQ6AR5 MA Modulator (allosteric modulator) DMQ6AR5 RN Synthesis, characterization, and monkey PET studies of [ ]MK-1312, a PET tracer for quantification of mGluR1 receptor occupancy by MK-5435. Synapse. 2011 Feb;65(2):125-35. DMQ6AR5 RU https://pubmed.ncbi.nlm.nih.gov/20524178 DMXIO84 DI DMXIO84 DMXIO84 DN [18F]SPA-RQ DMXIO84 MI TTZPO1L DMXIO84 MN Substance-P receptor (TACR1) DMXIO84 MT DTT DMXIO84 MA Antagonist DMXIO84 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 360). DMXIO84 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=360 DMH3BG5 DI DMH3BG5 DMH3BG5 DN [1-Benzyl-1H-quinolin-(4E)-ylidene]-hexyl-amine DMH3BG5 MI TTY3UE6 DMH3BG5 MN Voltage-gated potassium channel Kv1.3 (KCNA3) DMH3BG5 MT DTT DMH3BG5 MA Inhibitor DMH3BG5 RN Novel inhibitors of potassium ion channels on human T lymphocytes. J Med Chem. 1995 May 26;38(11):1877-83. DMH3BG5 RU https://pubmed.ncbi.nlm.nih.gov/7540207 DMS1YN3 DI DMS1YN3 DMS1YN3 DN [1-bromo-(3S)-hydrox-4-(palmitoyloxy)butyl]phosphate DMS1YN3 MI TT7ZMY4 DMS1YN3 MN Lysophosphatidic acid receptor 4 (LPAR4) DMS1YN3 MT DTT DMS1YN3 MA Antagonist DMS1YN3 RN LPA and its analogs-attractive tools for elucidation of LPA biology and drug development. Curr Med Chem. 2008;15(21):2122-31. DMS1YN3 RU https://pubmed.ncbi.nlm.nih.gov/18781939 DMSPMHE DI DMSPMHE DMSPMHE DN [2-(1H-Benzoimidazol-4-yloxy)-ethyl]-benzyl-amine DMSPMHE MI TTEX248 DMSPMHE MN Dopamine D2 receptor (D2R) DMSPMHE MT DTT DMSPMHE MA Inhibitor DMSPMHE RN New generation dopaminergic agents. 7. Heterocyclic bioisosteres that exploit the 3-OH-phenoxyethylamine D2 template. Bioorg Med Chem Lett. 1999 Sep 6;9(17):2593-8. DMSPMHE RU https://pubmed.ncbi.nlm.nih.gov/10498215 DMSPMHE DI DMSPMHE DMSPMHE DN [2-(1H-Benzoimidazol-4-yloxy)-ethyl]-benzyl-amine DMSPMHE MI TT4C8EA DMSPMHE MN Dopamine D3 receptor (D3R) DMSPMHE MT DTT DMSPMHE MA Inhibitor DMSPMHE RN New generation dopaminergic agents. 7. Heterocyclic bioisosteres that exploit the 3-OH-phenoxyethylamine D2 template. Bioorg Med Chem Lett. 1999 Sep 6;9(17):2593-8. DMSPMHE RU https://pubmed.ncbi.nlm.nih.gov/10498215 DMSPMHE DI DMSPMHE DMSPMHE DN [2-(1H-Benzoimidazol-4-yloxy)-ethyl]-benzyl-amine DMSPMHE MI TTE0A2F DMSPMHE MN Dopamine D4 receptor (D4R) DMSPMHE MT DTT DMSPMHE MA Inhibitor DMSPMHE RN New generation dopaminergic agents. 7. Heterocyclic bioisosteres that exploit the 3-OH-phenoxyethylamine D2 template. Bioorg Med Chem Lett. 1999 Sep 6;9(17):2593-8. DMSPMHE RU https://pubmed.ncbi.nlm.nih.gov/10498215 DMAJCVL DI DMAJCVL DMAJCVL DN [2-(3-Benzyl-3H-inden-1-yl)-ethyl]-methyl-amine DMAJCVL MI TTJS8PY DMAJCVL MN 5-HT 6 receptor (HTR6) DMAJCVL MT DTT DMAJCVL MA Inhibitor DMAJCVL RN Binding of isotryptamines and indenes at h5-HT6 serotonin receptors. Bioorg Med Chem Lett. 2005 Apr 15;15(8):1987-91. DMAJCVL RU https://pubmed.ncbi.nlm.nih.gov/15808453 DMU5P8O DI DMU5P8O DMU5P8O DN [2-(3-Benzyl-3H-indol-1-yl)-ethyl]-dimethyl-amine DMU5P8O MI TTJS8PY DMU5P8O MN 5-HT 6 receptor (HTR6) DMU5P8O MT DTT DMU5P8O MA Inhibitor DMU5P8O RN Possible differences in modes of agonist and antagonist binding at human 5-HT6 receptors. Bioorg Med Chem Lett. 2004 Sep 6;14(17):4569-73. DMU5P8O RU https://pubmed.ncbi.nlm.nih.gov/15357994 DMBTRN6 DI DMBTRN6 DMBTRN6 DN [2-(3-Benzyl-indol-1-yl)-ethyl]-dimethyl-amine DMBTRN6 MI TTJS8PY DMBTRN6 MN 5-HT 6 receptor (HTR6) DMBTRN6 MT DTT DMBTRN6 MA Inhibitor DMBTRN6 RN Binding of isotryptamines and indenes at h5-HT6 serotonin receptors. Bioorg Med Chem Lett. 2005 Apr 15;15(8):1987-91. DMBTRN6 RU https://pubmed.ncbi.nlm.nih.gov/15808453 DM1RW4U DI DM1RW4U DM1RW4U DN [2-(3H-Indol-1-yl)-ethyl]-dimethyl-amine DM1RW4U MI TTJS8PY DM1RW4U MN 5-HT 6 receptor (HTR6) DM1RW4U MT DTT DM1RW4U MA Inhibitor DM1RW4U RN Possible differences in modes of agonist and antagonist binding at human 5-HT6 receptors. Bioorg Med Chem Lett. 2004 Sep 6;14(17):4569-73. DM1RW4U RU https://pubmed.ncbi.nlm.nih.gov/15357994 DMDIH96 DI DMDIH96 DMDIH96 DN [2-(4-Fluoro-1H-indol-3-yl)-ethyl]-dimethyl-amine DMDIH96 MI TTJQOD7 DMDIH96 MN 5-HT 2A receptor (HTR2A) DMDIH96 MT DTT DMDIH96 MA Inhibitor DMDIH96 RN SAR of psilocybin analogs: discovery of a selective 5-HT 2C agonist. Bioorg Med Chem Lett. 2005 Oct 15;15(20):4555-9. DMDIH96 RU https://pubmed.ncbi.nlm.nih.gov/16061378 DMDIH96 DI DMDIH96 DMDIH96 DN [2-(4-Fluoro-1H-indol-3-yl)-ethyl]-dimethyl-amine DMDIH96 MI TT0K1SC DMDIH96 MN 5-HT 2B receptor (HTR2B) DMDIH96 MT DTT DMDIH96 MA Inhibitor DMDIH96 RN SAR of psilocybin analogs: discovery of a selective 5-HT 2C agonist. Bioorg Med Chem Lett. 2005 Oct 15;15(20):4555-9. DMDIH96 RU https://pubmed.ncbi.nlm.nih.gov/16061378 DMDIH96 DI DMDIH96 DMDIH96 DN [2-(4-Fluoro-1H-indol-3-yl)-ethyl]-dimethyl-amine DMDIH96 MI TTWJBZ5 DMDIH96 MN 5-HT 2C receptor (HTR2C) DMDIH96 MT DTT DMDIH96 MA Inhibitor DMDIH96 RN SAR of psilocybin analogs: discovery of a selective 5-HT 2C agonist. Bioorg Med Chem Lett. 2005 Oct 15;15(20):4555-9. DMDIH96 RU https://pubmed.ncbi.nlm.nih.gov/16061378 DMOZ73L DI DMOZ73L DMOZ73L DN [2-(5-Ethyl-1H-indol-3-yl)-ethyl]-dimethyl-amine DMOZ73L MI TTK8CXU DMOZ73L MN 5-HT 1B receptor (HTR1B) DMOZ73L MT DTT DMOZ73L MA Inhibitor DMOZ73L RN 5-Alkyltryptamine derivatives as highly selective and potent 5-HT1D receptor agonists. Bioorg Med Chem Lett. 2000 Aug 7;10(15):1707-9. DMOZ73L RU https://pubmed.ncbi.nlm.nih.gov/10937729 DMOZ73L DI DMOZ73L DMOZ73L DN [2-(5-Ethyl-1H-indol-3-yl)-ethyl]-dimethyl-amine DMOZ73L MI TT6MSOK DMOZ73L MN 5-HT 1D receptor (HTR1D) DMOZ73L MT DTT DMOZ73L MA Inhibitor DMOZ73L RN 5-Alkyltryptamine derivatives as highly selective and potent 5-HT1D receptor agonists. Bioorg Med Chem Lett. 2000 Aug 7;10(15):1707-9. DMOZ73L RU https://pubmed.ncbi.nlm.nih.gov/10937729 DM5LVIR DI DM5LVIR DM5LVIR DN [2-(6-Chloro-purin-9-yl)ethyl]-bisphosphonic acid DM5LVIR MI TTIKWV4 DM5LVIR MN Geranyltranstransferase (FDPS) DM5LVIR MT DTT DM5LVIR MA Inhibitor DM5LVIR RN Design, synthesis, and biological evaluation of novel aminobisphosphonates possessing an in vivo antitumor activity through a gammadelta-T lymphocy... J Med Chem. 2008 Nov 13;51(21):6800-7. DM5LVIR RU https://pubmed.ncbi.nlm.nih.gov/18937434 DMHPBQC DI DMHPBQC DMHPBQC DN [2-(6-Methoxy-indol-1-yl)-ethyl]-dimethyl-amine DMHPBQC MI TTJQOD7 DMHPBQC MN 5-HT 2A receptor (HTR2A) DMHPBQC MT DTT DMHPBQC MA Inhibitor DMHPBQC RN Evaluation of isotryptamine derivatives at 5-HT(2) serotonin receptors. Bioorg Med Chem Lett. 2002 Jan 21;12(2):155-8. DMHPBQC RU https://pubmed.ncbi.nlm.nih.gov/11755343 DM98MXT DI DM98MXT DM98MXT DN [2-(Benzoimidazol-1-yl)ethyl]-bisphosphonic acid DM98MXT MI TTIKWV4 DM98MXT MN Geranyltranstransferase (FDPS) DM98MXT MT DTT DM98MXT MA Inhibitor DM98MXT RN Design, synthesis, and biological evaluation of novel aminobisphosphonates possessing an in vivo antitumor activity through a gammadelta-T lymphocy... J Med Chem. 2008 Nov 13;51(21):6800-7. DM98MXT RU https://pubmed.ncbi.nlm.nih.gov/18937434 DM37C25 DI DM37C25 DM37C25 DN [2-(Biphenyl-4-sulfonyl)phenyl]acetic Acid DM37C25 MI TTXZ0KQ DM37C25 MN Matrix metalloproteinase-12 (MMP-12) DM37C25 MT DTT DM37C25 MA Inhibitor DM37C25 RN Design, synthesis, biological evaluation, and NMR studies of a new series of arylsulfones as selective and potent matrix metalloproteinase-12 inhib... J Med Chem. 2009 Oct 22;52(20):6347-61. DM37C25 RU https://pubmed.ncbi.nlm.nih.gov/19775099 DM37C25 DI DM37C25 DM37C25 DN [2-(Biphenyl-4-sulfonyl)phenyl]acetic Acid DM37C25 MI TTHY57M DM37C25 MN Matrix metalloproteinase-13 (MMP-13) DM37C25 MT DTT DM37C25 MA Inhibitor DM37C25 RN Design, synthesis, biological evaluation, and NMR studies of a new series of arylsulfones as selective and potent matrix metalloproteinase-12 inhib... J Med Chem. 2009 Oct 22;52(20):6347-61. DM37C25 RU https://pubmed.ncbi.nlm.nih.gov/19775099 DM37C25 DI DM37C25 DM37C25 DN [2-(Biphenyl-4-sulfonyl)phenyl]acetic Acid DM37C25 MI TTJ4QE7 DM37C25 MN Matrix metalloproteinase-14 (MMP-14) DM37C25 MT DTT DM37C25 MA Inhibitor DM37C25 RN Design, synthesis, biological evaluation, and NMR studies of a new series of arylsulfones as selective and potent matrix metalloproteinase-12 inhib... J Med Chem. 2009 Oct 22;52(20):6347-61. DM37C25 RU https://pubmed.ncbi.nlm.nih.gov/19775099 DM37C25 DI DM37C25 DM37C25 DN [2-(Biphenyl-4-sulfonyl)phenyl]acetic Acid DM37C25 MI TTLM12X DM37C25 MN Matrix metalloproteinase-2 (MMP-2) DM37C25 MT DTT DM37C25 MA Inhibitor DM37C25 RN Design, synthesis, biological evaluation, and NMR studies of a new series of arylsulfones as selective and potent matrix metalloproteinase-12 inhib... J Med Chem. 2009 Oct 22;52(20):6347-61. DM37C25 RU https://pubmed.ncbi.nlm.nih.gov/19775099 DM37C25 DI DM37C25 DM37C25 DN [2-(Biphenyl-4-sulfonyl)phenyl]acetic Acid DM37C25 MI TTYRF5E DM37C25 MN Matrix metalloproteinase-21 (MMP-21) DM37C25 MT DTT DM37C25 MA Inhibitor DM37C25 RN Design, synthesis, biological evaluation, and NMR studies of a new series of arylsulfones as selective and potent matrix metalloproteinase-12 inhib... J Med Chem. 2009 Oct 22;52(20):6347-61. DM37C25 RU https://pubmed.ncbi.nlm.nih.gov/19775099 DM37C25 DI DM37C25 DM37C25 DN [2-(Biphenyl-4-sulfonyl)phenyl]acetic Acid DM37C25 MI TTGA1IV DM37C25 MN Matrix metalloproteinase-8 (MMP-8) DM37C25 MT DTT DM37C25 MA Inhibitor DM37C25 RN Design, synthesis, biological evaluation, and NMR studies of a new series of arylsulfones as selective and potent matrix metalloproteinase-12 inhib... J Med Chem. 2009 Oct 22;52(20):6347-61. DM37C25 RU https://pubmed.ncbi.nlm.nih.gov/19775099 DM37C25 DI DM37C25 DM37C25 DN [2-(Biphenyl-4-sulfonyl)phenyl]acetic Acid DM37C25 MI TT6X50U DM37C25 MN Matrix metalloproteinase-9 (MMP-9) DM37C25 MT DTT DM37C25 MA Inhibitor DM37C25 RN Design, synthesis, biological evaluation, and NMR studies of a new series of arylsulfones as selective and potent matrix metalloproteinase-12 inhib... J Med Chem. 2009 Oct 22;52(20):6347-61. DM37C25 RU https://pubmed.ncbi.nlm.nih.gov/19775099 DMQZUD9 DI DMQZUD9 DMQZUD9 DN [2-(Imidazol-1-yl)ethyl]-bisphosphonic acid DMQZUD9 MI TTIKWV4 DMQZUD9 MN Geranyltranstransferase (FDPS) DMQZUD9 MT DTT DMQZUD9 MA Inhibitor DMQZUD9 RN Design, synthesis, and biological evaluation of novel aminobisphosphonates possessing an in vivo antitumor activity through a gammadelta-T lymphocy... J Med Chem. 2008 Nov 13;51(21):6800-7. DMQZUD9 RU https://pubmed.ncbi.nlm.nih.gov/18937434 DMBVDY5 DI DMBVDY5 DMBVDY5 DN [2-(Imidazol-2-yl-thio)ethyl]-bisphosphonic acid DMBVDY5 MI TTIKWV4 DMBVDY5 MN Geranyltranstransferase (FDPS) DMBVDY5 MT DTT DMBVDY5 MA Inhibitor DMBVDY5 RN Design, synthesis, and biological evaluation of novel aminobisphosphonates possessing an in vivo antitumor activity through a gammadelta-T lymphocy... J Med Chem. 2008 Nov 13;51(21):6800-7. DMBVDY5 RU https://pubmed.ncbi.nlm.nih.gov/18937434 DM3VT8M DI DM3VT8M DM3VT8M DN [2-(Purin-9-yl)ethyl]-bisphosphonic acid DM3VT8M MI TTIKWV4 DM3VT8M MN Geranyltranstransferase (FDPS) DM3VT8M MT DTT DM3VT8M MA Inhibitor DM3VT8M RN Design, synthesis, and biological evaluation of novel aminobisphosphonates possessing an in vivo antitumor activity through a gammadelta-T lymphocy... J Med Chem. 2008 Nov 13;51(21):6800-7. DM3VT8M RU https://pubmed.ncbi.nlm.nih.gov/18937434 DMJN8XK DI DMJN8XK DMJN8XK DN [2-(Pyrazol-1-yl)ethyl]-bisphosphonic acid DMJN8XK MI TTIKWV4 DMJN8XK MN Geranyltranstransferase (FDPS) DMJN8XK MT DTT DMJN8XK MA Inhibitor DMJN8XK RN Design, synthesis, and biological evaluation of novel aminobisphosphonates possessing an in vivo antitumor activity through a gammadelta-T lymphocy... J Med Chem. 2008 Nov 13;51(21):6800-7. DMJN8XK RU https://pubmed.ncbi.nlm.nih.gov/18937434 DMI9RLZ DI DMI9RLZ DMI9RLZ DN [2(R,S)-2-Sulfanylheptanoyl]-Phe-Ala DMI9RLZ MI TT5TKPM DMI9RLZ MN Neutral endopeptidase (MME) DMI9RLZ MT DTT DMI9RLZ MA Inhibitor DMI9RLZ RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMI9RLZ RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMI9RLZ DI DMI9RLZ DMI9RLZ DN [2(R,S)-2-Sulfanylheptanoyl]-Phe-Ala DMI9RLZ MI TTVDSZ0 DMI9RLZ MN Poly [ADP-ribose] polymerase 1 (PARP1) DMI9RLZ MT DTT DMI9RLZ MA Inhibitor DMI9RLZ RN Identification of potent nontoxic poly(ADP-Ribose) polymerase-1 inhibitors: chemopotentiation and pharmacological studies. Clin Cancer Res. 2003 Jul;9(7):2711-8. DMI9RLZ RU https://pubmed.ncbi.nlm.nih.gov/12855651 DMRQC1F DI DMRQC1F DMRQC1F DN [2,2':5',2'']Terthiophen-4-yl-methanol DMRQC1F MI TTFJ8Q1 DMRQC1F MN Protein kinase C alpha (PRKCA) DMRQC1F MT DTT DMRQC1F MA Inhibitor DMRQC1F RN Novel protein kinase C inhibitors: synthesis and PKC inhibition of beta-substituted polythiophene derivatives. Bioorg Med Chem Lett. 1999 Aug 2;9(15):2279-82. DMRQC1F RU https://pubmed.ncbi.nlm.nih.gov/10465561 DMRQC1F DI DMRQC1F DMRQC1F DN [2,2':5',2'']Terthiophen-4-yl-methanol DMRQC1F MI TTYPXQF DMRQC1F MN Protein kinase C beta (PRKCB) DMRQC1F MT DTT DMRQC1F MA Inhibitor DMRQC1F RN Novel protein kinase C inhibitors: synthesis and PKC inhibition of beta-substituted polythiophene derivatives. Bioorg Med Chem Lett. 1999 Aug 2;9(15):2279-82. DMRQC1F RU https://pubmed.ncbi.nlm.nih.gov/10465561 DMRQC1F DI DMRQC1F DMRQC1F DN [2,2':5',2'']Terthiophen-4-yl-methanol DMRQC1F MI TT9WJ8U DMRQC1F MN Protein kinase C delta (PRKCD) DMRQC1F MT DTT DMRQC1F MA Inhibitor DMRQC1F RN Novel protein kinase C inhibitors: synthesis and PKC inhibition of beta-substituted polythiophene derivatives. Bioorg Med Chem Lett. 1999 Aug 2;9(15):2279-82. DMRQC1F RU https://pubmed.ncbi.nlm.nih.gov/10465561 DMRQC1F DI DMRQC1F DMRQC1F DN [2,2':5',2'']Terthiophen-4-yl-methanol DMRQC1F MI TTBZ7OD DMRQC1F MN Protein kinase C epsilon (PRKCE) DMRQC1F MT DTT DMRQC1F MA Inhibitor DMRQC1F RN Novel protein kinase C inhibitors: synthesis and PKC inhibition of beta-substituted polythiophene derivatives. Bioorg Med Chem Lett. 1999 Aug 2;9(15):2279-82. DMRQC1F RU https://pubmed.ncbi.nlm.nih.gov/10465561 DMRQC1F DI DMRQC1F DMRQC1F DN [2,2':5',2'']Terthiophen-4-yl-methanol DMRQC1F MI TTRFOXJ DMRQC1F MN Protein kinase C gamma (PRKCG) DMRQC1F MT DTT DMRQC1F MA Inhibitor DMRQC1F RN Novel protein kinase C inhibitors: synthesis and PKC inhibition of beta-substituted polythiophene derivatives. Bioorg Med Chem Lett. 1999 Aug 2;9(15):2279-82. DMRQC1F RU https://pubmed.ncbi.nlm.nih.gov/10465561 DMRQC1F DI DMRQC1F DMRQC1F DN [2,2':5',2'']Terthiophen-4-yl-methanol DMRQC1F MI TT8QL1J DMRQC1F MN Protein kinase C theta (PRKCQ) DMRQC1F MT DTT DMRQC1F MA Inhibitor DMRQC1F RN Novel protein kinase C inhibitors: synthesis and PKC inhibition of beta-substituted polythiophene derivatives. Bioorg Med Chem Lett. 1999 Aug 2;9(15):2279-82. DMRQC1F RU https://pubmed.ncbi.nlm.nih.gov/10465561 DMRQC1F DI DMRQC1F DMRQC1F DN [2,2':5',2'']Terthiophen-4-yl-methanol DMRQC1F MI TTUWGRA DMRQC1F MN Protein kinase C zeta (PRKCZ) DMRQC1F MT DTT DMRQC1F MA Inhibitor DMRQC1F RN Novel protein kinase C inhibitors: synthesis and PKC inhibition of beta-substituted polythiophene derivatives. Bioorg Med Chem Lett. 1999 Aug 2;9(15):2279-82. DMRQC1F RU https://pubmed.ncbi.nlm.nih.gov/10465561 DMWDNLI DI DMWDNLI DMWDNLI DN [2,2':5',2'']Terthiophene-4,5''-dicarbaldehyde DMWDNLI MI TTFJ8Q1 DMWDNLI MN Protein kinase C alpha (PRKCA) DMWDNLI MT DTT DMWDNLI MA Inhibitor DMWDNLI RN Novel protein kinase C inhibitors: synthesis and PKC inhibition of beta-substituted polythiophene derivatives. Bioorg Med Chem Lett. 1999 Aug 2;9(15):2279-82. DMWDNLI RU https://pubmed.ncbi.nlm.nih.gov/10465561 DMWDNLI DI DMWDNLI DMWDNLI DN [2,2':5',2'']Terthiophene-4,5''-dicarbaldehyde DMWDNLI MI TTYPXQF DMWDNLI MN Protein kinase C beta (PRKCB) DMWDNLI MT DTT DMWDNLI MA Inhibitor DMWDNLI RN Novel protein kinase C inhibitors: synthesis and PKC inhibition of beta-substituted polythiophene derivatives. Bioorg Med Chem Lett. 1999 Aug 2;9(15):2279-82. DMWDNLI RU https://pubmed.ncbi.nlm.nih.gov/10465561 DMWDNLI DI DMWDNLI DMWDNLI DN [2,2':5',2'']Terthiophene-4,5''-dicarbaldehyde DMWDNLI MI TT9WJ8U DMWDNLI MN Protein kinase C delta (PRKCD) DMWDNLI MT DTT DMWDNLI MA Inhibitor DMWDNLI RN Novel protein kinase C inhibitors: synthesis and PKC inhibition of beta-substituted polythiophene derivatives. Bioorg Med Chem Lett. 1999 Aug 2;9(15):2279-82. DMWDNLI RU https://pubmed.ncbi.nlm.nih.gov/10465561 DMWDNLI DI DMWDNLI DMWDNLI DN [2,2':5',2'']Terthiophene-4,5''-dicarbaldehyde DMWDNLI MI TTBZ7OD DMWDNLI MN Protein kinase C epsilon (PRKCE) DMWDNLI MT DTT DMWDNLI MA Inhibitor DMWDNLI RN Novel protein kinase C inhibitors: synthesis and PKC inhibition of beta-substituted polythiophene derivatives. Bioorg Med Chem Lett. 1999 Aug 2;9(15):2279-82. DMWDNLI RU https://pubmed.ncbi.nlm.nih.gov/10465561 DMWDNLI DI DMWDNLI DMWDNLI DN [2,2':5',2'']Terthiophene-4,5''-dicarbaldehyde DMWDNLI MI TTRFOXJ DMWDNLI MN Protein kinase C gamma (PRKCG) DMWDNLI MT DTT DMWDNLI MA Inhibitor DMWDNLI RN Novel protein kinase C inhibitors: synthesis and PKC inhibition of beta-substituted polythiophene derivatives. Bioorg Med Chem Lett. 1999 Aug 2;9(15):2279-82. DMWDNLI RU https://pubmed.ncbi.nlm.nih.gov/10465561 DMWDNLI DI DMWDNLI DMWDNLI DN [2,2':5',2'']Terthiophene-4,5''-dicarbaldehyde DMWDNLI MI TT8QL1J DMWDNLI MN Protein kinase C theta (PRKCQ) DMWDNLI MT DTT DMWDNLI MA Inhibitor DMWDNLI RN Novel protein kinase C inhibitors: synthesis and PKC inhibition of beta-substituted polythiophene derivatives. Bioorg Med Chem Lett. 1999 Aug 2;9(15):2279-82. DMWDNLI RU https://pubmed.ncbi.nlm.nih.gov/10465561 DMWDNLI DI DMWDNLI DMWDNLI DN [2,2':5',2'']Terthiophene-4,5''-dicarbaldehyde DMWDNLI MI TTUWGRA DMWDNLI MN Protein kinase C zeta (PRKCZ) DMWDNLI MT DTT DMWDNLI MA Inhibitor DMWDNLI RN Novel protein kinase C inhibitors: synthesis and PKC inhibition of beta-substituted polythiophene derivatives. Bioorg Med Chem Lett. 1999 Aug 2;9(15):2279-82. DMWDNLI RU https://pubmed.ncbi.nlm.nih.gov/10465561 DM2S5EJ DI DM2S5EJ DM2S5EJ DN [2,2':5',2'']Terthiophene-4-carbaldehyde DM2S5EJ MI TTFJ8Q1 DM2S5EJ MN Protein kinase C alpha (PRKCA) DM2S5EJ MT DTT DM2S5EJ MA Inhibitor DM2S5EJ RN Novel protein kinase C inhibitors: synthesis and PKC inhibition of beta-substituted polythiophene derivatives. Bioorg Med Chem Lett. 1999 Aug 2;9(15):2279-82. DM2S5EJ RU https://pubmed.ncbi.nlm.nih.gov/10465561 DM2S5EJ DI DM2S5EJ DM2S5EJ DN [2,2':5',2'']Terthiophene-4-carbaldehyde DM2S5EJ MI TTYPXQF DM2S5EJ MN Protein kinase C beta (PRKCB) DM2S5EJ MT DTT DM2S5EJ MA Inhibitor DM2S5EJ RN Novel protein kinase C inhibitors: synthesis and PKC inhibition of beta-substituted polythiophene derivatives. Bioorg Med Chem Lett. 1999 Aug 2;9(15):2279-82. DM2S5EJ RU https://pubmed.ncbi.nlm.nih.gov/10465561 DM2S5EJ DI DM2S5EJ DM2S5EJ DN [2,2':5',2'']Terthiophene-4-carbaldehyde DM2S5EJ MI TT9WJ8U DM2S5EJ MN Protein kinase C delta (PRKCD) DM2S5EJ MT DTT DM2S5EJ MA Inhibitor DM2S5EJ RN Novel protein kinase C inhibitors: synthesis and PKC inhibition of beta-substituted polythiophene derivatives. Bioorg Med Chem Lett. 1999 Aug 2;9(15):2279-82. DM2S5EJ RU https://pubmed.ncbi.nlm.nih.gov/10465561 DM2S5EJ DI DM2S5EJ DM2S5EJ DN [2,2':5',2'']Terthiophene-4-carbaldehyde DM2S5EJ MI TTBZ7OD DM2S5EJ MN Protein kinase C epsilon (PRKCE) DM2S5EJ MT DTT DM2S5EJ MA Inhibitor DM2S5EJ RN Novel protein kinase C inhibitors: synthesis and PKC inhibition of beta-substituted polythiophene derivatives. Bioorg Med Chem Lett. 1999 Aug 2;9(15):2279-82. DM2S5EJ RU https://pubmed.ncbi.nlm.nih.gov/10465561 DM2S5EJ DI DM2S5EJ DM2S5EJ DN [2,2':5',2'']Terthiophene-4-carbaldehyde DM2S5EJ MI TTRFOXJ DM2S5EJ MN Protein kinase C gamma (PRKCG) DM2S5EJ MT DTT DM2S5EJ MA Inhibitor DM2S5EJ RN Novel protein kinase C inhibitors: synthesis and PKC inhibition of beta-substituted polythiophene derivatives. Bioorg Med Chem Lett. 1999 Aug 2;9(15):2279-82. DM2S5EJ RU https://pubmed.ncbi.nlm.nih.gov/10465561 DM2S5EJ DI DM2S5EJ DM2S5EJ DN [2,2':5',2'']Terthiophene-4-carbaldehyde DM2S5EJ MI TT8QL1J DM2S5EJ MN Protein kinase C theta (PRKCQ) DM2S5EJ MT DTT DM2S5EJ MA Inhibitor DM2S5EJ RN Novel protein kinase C inhibitors: synthesis and PKC inhibition of beta-substituted polythiophene derivatives. Bioorg Med Chem Lett. 1999 Aug 2;9(15):2279-82. DM2S5EJ RU https://pubmed.ncbi.nlm.nih.gov/10465561 DM2S5EJ DI DM2S5EJ DM2S5EJ DN [2,2':5',2'']Terthiophene-4-carbaldehyde DM2S5EJ MI TTUWGRA DM2S5EJ MN Protein kinase C zeta (PRKCZ) DM2S5EJ MT DTT DM2S5EJ MA Inhibitor DM2S5EJ RN Novel protein kinase C inhibitors: synthesis and PKC inhibition of beta-substituted polythiophene derivatives. Bioorg Med Chem Lett. 1999 Aug 2;9(15):2279-82. DM2S5EJ RU https://pubmed.ncbi.nlm.nih.gov/10465561 DM4WXD2 DI DM4WXD2 DM4WXD2 DN [2-Phenylacetophenone]thiosemicarbazone DM4WXD2 MI TT36ETB DM4WXD2 MN Cathepsin L (CTSL) DM4WXD2 MT DTT DM4WXD2 MA Inhibitor DM4WXD2 RN Functionalized benzophenone, thiophene, pyridine, and fluorene thiosemicarbazone derivatives as inhibitors of cathepsin L. Bioorg Med Chem Lett. 2010 Nov 15;20(22):6610-5. DM4WXD2 RU https://pubmed.ncbi.nlm.nih.gov/20933415 DM4BYEQ DI DM4BYEQ DM4BYEQ DN [3-(3,4-Dichloro-phenyl)-indan-1-yl]-methyl-amine DM4BYEQ MI TTVBI8W DM4BYEQ MN Dopamine transporter (DAT) DM4BYEQ MT DTT DM4BYEQ MA Inhibitor DM4BYEQ RN Synthesis and pharmacological evaluation of 3-(3,4-dichlorophenyl)-1-indanamine derivatives as nonselective ligands for biogenic amine transporters. J Med Chem. 2004 May 6;47(10):2624-34. DM4BYEQ RU https://pubmed.ncbi.nlm.nih.gov/15115403 DM4BYEQ DI DM4BYEQ DM4BYEQ DN [3-(3,4-Dichloro-phenyl)-indan-1-yl]-methyl-amine DM4BYEQ MI TTAWNKZ DM4BYEQ MN Norepinephrine transporter (NET) DM4BYEQ MT DTT DM4BYEQ MA Inhibitor DM4BYEQ RN Synthesis and pharmacological evaluation of 3-(3,4-dichlorophenyl)-1-indanamine derivatives as nonselective ligands for biogenic amine transporters. J Med Chem. 2004 May 6;47(10):2624-34. DM4BYEQ RU https://pubmed.ncbi.nlm.nih.gov/15115403 DM4BYEQ DI DM4BYEQ DM4BYEQ DN [3-(3,4-Dichloro-phenyl)-indan-1-yl]-methyl-amine DM4BYEQ MI TT3ROYC DM4BYEQ MN Serotonin transporter (SERT) DM4BYEQ MT DTT DM4BYEQ MA Inhibitor DM4BYEQ RN Synthesis and pharmacological evaluation of 3-(3,4-dichlorophenyl)-1-indanamine derivatives as nonselective ligands for biogenic amine transporters. J Med Chem. 2004 May 6;47(10):2624-34. DM4BYEQ RU https://pubmed.ncbi.nlm.nih.gov/15115403 DMGD487 DI DMGD487 DMGD487 DN [3-(4-Nonyl-benzylamino)-propyl]-phosphonic acid DMGD487 MI TT9JZCK DMGD487 MN Sphingosine-1-phosphate receptor 1 (S1PR1) DMGD487 MT DTT DMGD487 MA Inhibitor DMGD487 RN Design and synthesis of conformationally constrained 3-(N-alkylamino)propylphosphonic acids as potent agonists of sphingosine-1-phosphate (S1P) rec... Bioorg Med Chem Lett. 2004 Oct 4;14(19):4861-6. DMGD487 RU https://pubmed.ncbi.nlm.nih.gov/15341940 DMD0LCU DI DMD0LCU DMD0LCU DN [3-(5-Phenyl-oxazol-2-ylamino)-phenyl]-methanol DMD0LCU MI TTUTJGQ DMD0LCU MN Vascular endothelial growth factor receptor 2 (KDR) DMD0LCU MT DTT DMD0LCU MA Inhibitor DMD0LCU RN Discovery and evaluation of 2-anilino-5-aryloxazoles as a novel class of VEGFR2 kinase inhibitors. J Med Chem. 2005 Mar 10;48(5):1610-9. DMD0LCU RU https://pubmed.ncbi.nlm.nih.gov/15743202 DMD0LCU DI DMD0LCU DMD0LCU DN [3-(5-Phenyl-oxazol-2-ylamino)-phenyl]-methanol DMD0LCU MI TTDCBX5 DMD0LCU MN Vascular endothelial growth factor receptor 3 (FLT-4) DMD0LCU MT DTT DMD0LCU MA Inhibitor DMD0LCU RN Discovery and evaluation of 2-anilino-5-aryloxazoles as a novel class of VEGFR2 kinase inhibitors. J Med Chem. 2005 Mar 10;48(5):1610-9. DMD0LCU RU https://pubmed.ncbi.nlm.nih.gov/15743202 DMD0LCU DI DMD0LCU DMD0LCU DN [3-(5-Phenyl-oxazol-2-ylamino)-phenyl]-methanol DMD0LCU MI TT1VAUK DMD0LCU MN VEGFR1 messenger RNA (VEGFR1 mRNA) DMD0LCU MT DTT DMD0LCU MA Inhibitor DMD0LCU RN Discovery and evaluation of 2-anilino-5-aryloxazoles as a novel class of VEGFR2 kinase inhibitors. J Med Chem. 2005 Mar 10;48(5):1610-9. DMD0LCU RU https://pubmed.ncbi.nlm.nih.gov/15743202 DMRBJ4V DI DMRBJ4V DMRBJ4V DN [3-(Biphenyl-4-yloxy)-propyl]-dimethyl-amine DMRBJ4V MI TT7O8ZA DMRBJ4V MN Lanosterol synthase (LSS) DMRBJ4V MT DTT DMRBJ4V MA Inhibitor DMRBJ4V RN Oxidosqualene cyclase inhibitors as antimicrobial agents. J Med Chem. 2003 Sep 25;46(20):4240-3. DMRBJ4V RU https://pubmed.ncbi.nlm.nih.gov/13678402 DMHU4NS DI DMHU4NS DMHU4NS DN [3,4''']biflavone DMHU4NS MI TTT1JVS DMHU4NS MN Cytosolic phospholipase A2 (GIVA cPLA2) DMHU4NS MT DTT DMHU4NS MA Inhibitor DMHU4NS RN Inhibitory effect of synthetic C-C biflavones on various phospholipase A(2)s activity. Bioorg Med Chem. 2007 Nov 15;15(22):7138-43. DMHU4NS RU https://pubmed.ncbi.nlm.nih.gov/17826099 DMEMVY5 DI DMEMVY5 DMEMVY5 DN [32P]MRS2500 DMEMVY5 MI TTA93TL DMEMVY5 MN P2Y purinoceptor 1 (P2RY1) DMEMVY5 MT DTT DMEMVY5 MA Antagonist DMEMVY5 RN [32P]2-iodo-N6-methyl-(N)-methanocarba-2'-deoxyadenosine-3',5'-bisphosphate ([32P]MRS2500), a novel radioligand for quantification of native P2Y1 receptors. Br J Pharmacol. 2006 Mar;147(5):459-67. DMEMVY5 RU https://pubmed.ncbi.nlm.nih.gov/16299552 DM218VZ DI DM218VZ DM218VZ DN [33P]2MeSADP DM218VZ MI TT1FE3L DM218VZ MN P2Y purinoceptor 13 (P2RY13) DM218VZ MT DTT DM218VZ MA Agonist DM218VZ RN Pharmacological characterization of the human P2Y13 receptor. Mol Pharmacol. 2003 Jul;64(1):104-12. DM218VZ RU https://pubmed.ncbi.nlm.nih.gov/12815166 DMVUEYM DI DMVUEYM DMVUEYM DN [35S]ACPPB DMVUEYM MI TTHJTF7 DMVUEYM MN Glycine transporter GlyT-1 (SLC6A9) DMVUEYM MT DTT DMVUEYM MA Modulator DMVUEYM RN A novel radioligand for glycine transporter 1: characterization and use in autoradiographic and in vivo brain occupancy studies. Nucl Med Biol. 2008 Apr;35(3):315-25. DMVUEYM RU https://pubmed.ncbi.nlm.nih.gov/18355687 DMAYPTO DI DMAYPTO DMAYPTO DN [35S]ADPbetaS DMAYPTO MI TTA93TL DMAYPTO MN P2Y purinoceptor 1 (P2RY1) DMAYPTO MT DTT DMAYPTO MA Agonist DMAYPTO RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 323). DMAYPTO RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=323 DMQ0NK8 DI DMQ0NK8 DMQ0NK8 DN [35S]ibutamoren DMQ0NK8 MI TTWDC17 DMQ0NK8 MN Growth hormone secretagogue receptor 1 (GHSR) DMQ0NK8 MT DTT DMQ0NK8 MA Agonist DMQ0NK8 RN Molecular analysis of rat pituitary and hypothalamic growth hormone secretagogue receptors. Mol Endocrinol. 1997 Apr;11(4):415-23. DMQ0NK8 RU https://pubmed.ncbi.nlm.nih.gov/9092793 DMSHOQ8 DI DMSHOQ8 DMSHOQ8 DN [35S]-non-peptide OT antagonist DMSHOQ8 MI TTSCIUP DMSHOQ8 MN Oxytocin receptor (OTR) DMSHOQ8 MT DTT DMSHOQ8 MA Antagonist DMSHOQ8 RN A nonpeptide oxytocin receptor antagonist radioligand highly selective for human receptors. Eur J Pharmacol. 2002 Aug 16;450(1):19-28. DMSHOQ8 RU https://pubmed.ncbi.nlm.nih.gov/12176104 DMSD51L DI DMSD51L DMSD51L DN [35S]TBPS DMSD51L MI TTBMV1G DMSD51L MN GABA(A) receptor alpha-2 (GABRA2) DMSD51L MT DTT DMSD51L MA Blocker (channel blocker) DMSD51L RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 405). DMSD51L RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=405 DMSD51L DI DMSD51L DMSD51L DN [35S]TBPS DMSD51L MI TT37EDJ DMSD51L MN GABA(A) receptor alpha-3 (GABRA3) DMSD51L MT DTT DMSD51L MA Blocker (channel blocker) DMSD51L RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 406). DMSD51L RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=406 DMSD51L DI DMSD51L DMSD51L DN [35S]TBPS DMSD51L MI TTNZPQ1 DMSD51L MN GABA(A) receptor alpha-5 (GABRA5) DMSD51L MT DTT DMSD51L MA Blocker (channel blocker) DMSD51L RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 408). DMSD51L RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=408 DMSD51L DI DMSD51L DMSD51L DN [35S]TBPS DMSD51L MI TTEX6LM DMSD51L MN GABA(A) receptor gamma-3 (GABRG3) DMSD51L MT DTT DMSD51L MA Blocker (channel blocker) DMSD51L RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 415). DMSD51L RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=415 DMN35BY DI DMN35BY DMN35BY DN [3H](-)CGP 12177 DMN35BY MI TTMXGCW DMN35BY MN Adrenergic receptor beta-3 (ADRB3) DMN35BY MT DTT DMN35BY MA Agonist DMN35BY RN Binding of (-)-[3H]-CGP12177 at two sites in recombinant human beta 1-adrenoceptors and interaction with beta-blockers. Naunyn Schmiedebergs Arch Pharmacol. 2004 May;369(5):525-32. DMN35BY RU https://pubmed.ncbi.nlm.nih.gov/15060759 DM0KGHP DI DM0KGHP DM0KGHP DN [3H](-)devapamil DM0KGHP MI TT94HRF DM0KGHP MN Voltage-gated calcium channel alpha Cav1.1 (CACNA1S) DM0KGHP MT DTT DM0KGHP MA Inhibitor (gating inhibitor) DM0KGHP RN (-)-[3H]Desmethoxyverapamil, a novel Ca2+ channel probe. Binding characteristics and target size analysis of its receptor in skeletal muscle. FEBS Lett. 1984 Oct 29;176(2):371-7. DM0KGHP RU https://pubmed.ncbi.nlm.nih.gov/6092142 DM0KGHP DI DM0KGHP DM0KGHP DN [3H](-)devapamil DM0KGHP MI TTZIFHC DM0KGHP MN Voltage-gated calcium channel alpha Cav1.2 (CACNA1C) DM0KGHP MT DTT DM0KGHP MA Inhibitor (gating inhibitor) DM0KGHP RN Pharmacological, radioligand binding, and electrophysiological characteristics of FPL 64176, a novel nondihydropyridine Ca2+ channel activator, in cardiac and vascular preparations. Mol Pharmacol. 1991 Nov;40(5):734-41. DM0KGHP RU https://pubmed.ncbi.nlm.nih.gov/1719369 DM0KGHP DI DM0KGHP DM0KGHP DN [3H](-)devapamil DM0KGHP MI TTXHYV6 DM0KGHP MN Voltage-gated L-type calcium channel (L-CaC) DM0KGHP MT DTT DM0KGHP MA Blocker DM0KGHP RN Role of apoptosis in the kidney after reperfusion. Orv Hetil. 2008 Feb 17;149(7):305-15. DM0KGHP RU https://pubmed.ncbi.nlm.nih.gov/18258561 DMP6XL9 DI DMP6XL9 DMP6XL9 DN [3H](+)-cis-diltiazem DMP6XL9 MI TT94HRF DMP6XL9 MN Voltage-gated calcium channel alpha Cav1.1 (CACNA1S) DMP6XL9 MT DTT DMP6XL9 MA Inhibitor (gating inhibitor) DMP6XL9 RN High-affinity binding of DTZ323, a novel derivative of diltiazem, to rabbit skeletal muscle L-type Ca++ channels. J Pharmacol Exp Ther. 1997 Apr;281(1):173-9. DMP6XL9 RU https://pubmed.ncbi.nlm.nih.gov/9103495 DMP6XL9 DI DMP6XL9 DMP6XL9 DN [3H](+)-cis-diltiazem DMP6XL9 MI TTZIFHC DMP6XL9 MN Voltage-gated calcium channel alpha Cav1.2 (CACNA1C) DMP6XL9 MT DTT DMP6XL9 MA Inhibitor (gating inhibitor) DMP6XL9 RN SR 33557, a novel calcium entry blocker. II. Interactions with 1,4-dihydropyridine, phenylalkylamine and benzothiazepine binding sites in rat heart sarcolemmal membranes. J Pharmacol Exp Ther. 1990 Nov;255(2):600-7. DMP6XL9 RU https://pubmed.ncbi.nlm.nih.gov/2147036 DM7QE1J DI DM7QE1J DM7QE1J DN [3H](+)-isradipine DM7QE1J MI TT94HRF DM7QE1J MN Voltage-gated calcium channel alpha Cav1.1 (CACNA1S) DM7QE1J MT DTT DM7QE1J MA Inhibitor (gating inhibitor) DM7QE1J RN Biochemical characterization of plasma membrane isolated from human skeletal muscle. FEBS Lett. 1985 Sep 2;188(2):222-6. DM7QE1J RU https://pubmed.ncbi.nlm.nih.gov/2411596 DM7QE1J DI DM7QE1J DM7QE1J DN [3H](+)-isradipine DM7QE1J MI TTZIFHC DM7QE1J MN Voltage-gated calcium channel alpha Cav1.2 (CACNA1C) DM7QE1J MT DTT DM7QE1J MA Inhibitor (gating inhibitor) DM7QE1J RN Isoform-specific regulation of mood behavior and pancreatic beta cell and cardiovascular function by L-type Ca 2+ channels. J Clin Invest. 2004 May;113(10):1430-9. DM7QE1J RU https://pubmed.ncbi.nlm.nih.gov/15146240 DM7QE1J DI DM7QE1J DM7QE1J DN [3H](+)-isradipine DM7QE1J MI TT7RGTM DM7QE1J MN Voltage-gated calcium channel alpha Cav1.3 (CACNA1D) DM7QE1J MT DTT DM7QE1J MA Inhibitor (gating inhibitor) DM7QE1J RN alpha 1D (Cav1.3) subunits can form l-type Ca2+ channels activating at negative voltages. J Biol Chem. 2001 Jun 22;276(25):22100-6. DM7QE1J RU https://pubmed.ncbi.nlm.nih.gov/11285265 DMRPS2X DI DMRPS2X DMRPS2X DN [3H](R)-NPTS DMRPS2X MI TTHJTF7 DMRPS2X MN Glycine transporter GlyT-1 (SLC6A9) DMRPS2X MT DTT DMRPS2X MA Modulator DMRPS2X RN [3H]-(R)-NPTS, a radioligand for the type 1 glycine transporter. Bioorg Med Chem Lett. 2003 Apr 7;13(7):1291-2. DMRPS2X RU https://pubmed.ncbi.nlm.nih.gov/12657266 DM0B54M DI DM0B54M DM0B54M DN [3H](S)-zacopride DM0B54M MI TTPC4TU DM0B54M MN 5-HT 3A receptor (HTR3A) DM0B54M MT DTT DM0B54M MA Antagonist DM0B54M RN Autoradiographic distribution of [3H]-(S)-zacopride-labelled 5-HT3 receptors in human brain. J Neurol Sci. 1996 Dec;144(1-2):119-27. DM0B54M RU https://pubmed.ncbi.nlm.nih.gov/8994113 DMQO8AF DI DMQO8AF DMQO8AF DN [3H]2,2,2-TEMPS DMQO8AF MI TTXJ47W DMQO8AF MN Metabotropic glutamate receptor 2 (mGluR2) DMQO8AF MT DTT DMQO8AF MA Modulator (allosteric modulator) DMQO8AF RN Structural determinants of allosteric antagonism at metabotropic glutamate receptor 2: mechanistic studies with new potent negative allosteric modulators. Br J Pharmacol. 2011 Sep;164(2b):521-37. DMQO8AF RU https://pubmed.ncbi.nlm.nih.gov/21470207 DM5SWI1 DI DM5SWI1 DM5SWI1 DN [3H]4NMPB DM5SWI1 MI TTOXS3C DM5SWI1 MN Muscarinic acetylcholine receptor (CHRM) DM5SWI1 MT DTT DM5SWI1 MA Antagonist DM5SWI1 RN Cloned M1 muscarinic receptors mediate both adenylate cyclase inhibition and phosphoinositide turnover. EMBO J. 1988 Oct;7(10):3031-5. DM5SWI1 RU https://pubmed.ncbi.nlm.nih.gov/2846274 DMEAHFZ DI DMEAHFZ DMEAHFZ DN [3H]5-CT DMEAHFZ MI TT6MSOK DMEAHFZ MN 5-HT 1D receptor (HTR1D) DMEAHFZ MT DTT DMEAHFZ MA Agonist DMEAHFZ RN Serotonin 5-HT1B and 5-HT1D receptors form homodimers when expressed alone and heterodimers when co-expressed. FEBS Lett. 1999 Jul 30;456(1):63-7. DMEAHFZ RU https://pubmed.ncbi.nlm.nih.gov/10452531 DMEAHFZ DI DMEAHFZ DMEAHFZ DN [3H]5-CT DMEAHFZ MI TTRUFDT DMEAHFZ MN 5-HT 5A receptor (HTR5A) DMEAHFZ MT DTT DMEAHFZ MA Agonist DMEAHFZ RN Human 5-HT(5) receptors: the 5-HT(5A) receptor is functional but the 5-HT(5B) receptor was lost during mammalian evolution. Eur J Pharmacol. 2001 Apr 27;418(3):157-67. DMEAHFZ RU https://pubmed.ncbi.nlm.nih.gov/11343685 DMEAHFZ DI DMEAHFZ DMEAHFZ DN [3H]5-CT DMEAHFZ MI TT9KJ1X DMEAHFZ MN 5-HT 5B receptor (HTR5B) DMEAHFZ MT DTT DMEAHFZ MA Agonist DMEAHFZ RN Putative 5-ht5 receptors: localization in the mouse CNS and lack of effect in the inhibition of dural protein extravasation. Ann N Y Acad Sci. 1998 Dec 15;861:85-90. DMEAHFZ RU https://pubmed.ncbi.nlm.nih.gov/9928243 DMEAHFZ DI DMEAHFZ DMEAHFZ DN [3H]5-CT DMEAHFZ MI TTJS8PY DMEAHFZ MN 5-HT 6 receptor (HTR6) DMEAHFZ MT DTT DMEAHFZ MA Agonist DMEAHFZ RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 11). DMEAHFZ RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=11 DMEAHFZ DI DMEAHFZ DMEAHFZ DN [3H]5-CT DMEAHFZ MI TTO9X1H DMEAHFZ MN 5-HT 7 receptor (HTR7) DMEAHFZ MT DTT DMEAHFZ MA Agonist DMEAHFZ RN [(3)H]-SB-269970--A selective antagonist radioligand for 5-HT(7) receptors. Br J Pharmacol. 2000 May;130(2):409-17. DMEAHFZ RU https://pubmed.ncbi.nlm.nih.gov/10807680 DMYJXV7 DI DMYJXV7 DMYJXV7 DN [3H]5-HT DMYJXV7 MI TT6MSOK DMYJXV7 MN 5-HT 1D receptor (HTR1D) DMYJXV7 MT DTT DMYJXV7 MA Agonist DMYJXV7 RN Agonistic properties of alniditan, sumatriptan and dihydroergotamine on human 5-HT1B and 5-HT1D receptors expressed in various mammalian cell lines. Br J Pharmacol. 1998 Apr;123(8):1655-65. DMYJXV7 RU https://pubmed.ncbi.nlm.nih.gov/9605573 DMYJXV7 DI DMYJXV7 DMYJXV7 DN [3H]5-HT DMYJXV7 MI TTCPG9S DMYJXV7 MN 5-HT 1E receptor (HTR1E) DMYJXV7 MT DTT DMYJXV7 MA Agonist DMYJXV7 RN Molecular cloning of a serotonin receptor from human brain (5HT1E): a fifth 5HT1-like subtype. Proc Natl Acad Sci U S A. 1992 Jun 15;89(12):5517-21. DMYJXV7 RU https://pubmed.ncbi.nlm.nih.gov/1608964 DMYJXV7 DI DMYJXV7 DMYJXV7 DN [3H]5-HT DMYJXV7 MI TT0K1SC DMYJXV7 MN 5-HT 2B receptor (HTR2B) DMYJXV7 MT DTT DMYJXV7 MA Agonist DMYJXV7 RN Pharmacological characteristics of the newly cloned rat 5-hydroxytryptamine2F receptor. Mol Pharmacol. 1993 Mar;43(3):419-26. DMYJXV7 RU https://pubmed.ncbi.nlm.nih.gov/8450835 DMYJXV7 DI DMYJXV7 DMYJXV7 DN [3H]5-HT DMYJXV7 MI TTO9X1H DMYJXV7 MN 5-HT 7 receptor (HTR7) DMYJXV7 MT DTT DMYJXV7 MA Agonist DMYJXV7 RN Cloning of a novel human serotonin receptor (5-HT7) positively linked to adenylate cyclase. J Biol Chem. 1993 Nov 5;268(31):23422-6. DMYJXV7 RU https://pubmed.ncbi.nlm.nih.gov/8226867 DM50WFM DI DM50WFM DM50WFM DN [3H]5-oxo-ETE DM50WFM MI TT7WBSV DM50WFM MN Oxoeicosanoid receptor 1 (OXER1) DM50WFM MT DTT DM50WFM MA Agonist DM50WFM RN Receptors for the 5-oxo class of eicosanoids in neutrophils. J Biol Chem. 1998 Dec 4;273(49):32535-41. DM50WFM RU https://pubmed.ncbi.nlm.nih.gov/9829988 DM2PW8T DI DM2PW8T DM2PW8T DN [3H]7-OH-DPAT DM2PW8T MI TTEX248 DM2PW8T MN Dopamine D2 receptor (D2R) DM2PW8T MT DTT DM2PW8T MA Inhibitor DM2PW8T RN Structurally constrained hybrid derivatives containing octahydrobenzo[g or f]quinoline moieties for dopamine D2 and D3 receptors: binding character... J Med Chem. 2008 Dec 25;51(24):7806-19. DM2PW8T RU https://pubmed.ncbi.nlm.nih.gov/19053758 DM2PW8T DI DM2PW8T DM2PW8T DN [3H]7-OH-DPAT DM2PW8T MI TT4C8EA DM2PW8T MN Dopamine D3 receptor (D3R) DM2PW8T MT DTT DM2PW8T MA Agonist DM2PW8T RN Radioligand binding characterization of putative dopamine D3 receptor in human peripheral blood lymphocytes with [3H]7-OH-DPAT. J Neuroimmunol. 1995 May;58(2):139-44. DM2PW8T RU https://pubmed.ncbi.nlm.nih.gov/7759603 DM4KCYU DI DM4KCYU DM4KCYU DN [3H]8-OH-DPAT DM4KCYU MI TTSQIFT DM4KCYU MN 5-HT 1A receptor (HTR1A) DM4KCYU MT DTT DM4KCYU MA Agonist DM4KCYU RN Effect of ring fluorination on the pharmacology of hallucinogenic tryptamines. J Med Chem. 2000 Nov 30;43(24):4701-10. DM4KCYU RU https://pubmed.ncbi.nlm.nih.gov/11101361 DM4KCYU DI DM4KCYU DM4KCYU DN [3H]8-OH-DPAT DM4KCYU MI TTK8CXU DM4KCYU MN 5-HT 1B receptor (HTR1B) DM4KCYU MT DTT DM4KCYU MA Agonist DM4KCYU RN Actions of roxindole at recombinant human dopamine D2, D3 and D4 and serotonin 5-HT1A, 5-HT1B and 5-HT1D receptors. Naunyn Schmiedebergs Arch Pharmacol. 1999 Jun;359(6):447-53. DM4KCYU RU https://pubmed.ncbi.nlm.nih.gov/10431754 DM4KCYU DI DM4KCYU DM4KCYU DN [3H]8-OH-DPAT DM4KCYU MI TT6MSOK DM4KCYU MN 5-HT 1D receptor (HTR1D) DM4KCYU MT DTT DM4KCYU MA Agonist DM4KCYU RN Actions of roxindole at recombinant human dopamine D2, D3 and D4 and serotonin 5-HT1A, 5-HT1B and 5-HT1D receptors. Naunyn Schmiedebergs Arch Pharmacol. 1999 Jun;359(6):447-53. DM4KCYU RU https://pubmed.ncbi.nlm.nih.gov/10431754 DMTBAXD DI DMTBAXD DMTBAXD DN [3H]A317491 DMTBAXD MI TT2THBD DMTBAXD MN P2X purinoceptor 3 (P2RX3) DMTBAXD MT DTT DMTBAXD MA Antagonist DMTBAXD RN Crossing the pain barrier: P2 receptors as targets for novel analgesics. J Physiol. 2003 Dec 15;553(Pt 3):683-94. DMTBAXD RU https://pubmed.ncbi.nlm.nih.gov/14514872 DMSDY2Z DI DMSDY2Z DMSDY2Z DN [3H]A-585539 DMSDY2Z MI TTLA931 DMSDY2Z MN Neuronal acetylcholine receptor alpha-7 (CHRNA7) DMSDY2Z MT DTT DMSDY2Z MA Agonist DMSDY2Z RN [3H]A-585539 [(1S,4S)-2,2-dimethyl-5-(6-phenylpyridazin-3-yl)-5-aza-2-azoniabicyclo[2.2.1]heptane], a novel high-affinity alpha7 neuronal nicotinic... J Pharmacol Exp Ther. 2008 Jan;324(1):179-87. DMSDY2Z RU https://pubmed.ncbi.nlm.nih.gov/17959745 DMVJKCH DI DMVJKCH DMVJKCH DN [3H]A778317 DMVJKCH MI TTMI6F5 DMVJKCH MN Transient receptor potential cation channel V1 (TRPV1) DMVJKCH MT DTT DMVJKCH MA Blocker (channel blocker) DMVJKCH RN [3H]A-778317 [1-((R)-5-tert-butyl-indan-1-yl)-3-isoquinolin-5-yl-urea]: a novel, stereoselective, high-affinity antagonist is a useful radioligand ... J Pharmacol Exp Ther. 2007 Oct;323(1):285-93. DMVJKCH RU https://pubmed.ncbi.nlm.nih.gov/17660385 DMWV5C3 DI DMWV5C3 DMWV5C3 DN [3H]alphabeta-meATP DMWV5C3 MI TT2QM9D DMWV5C3 MN Adenylate cyclase (ADCY) DMWV5C3 MT DTT DMWV5C3 MA Inhibitor DMWV5C3 RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMWV5C3 RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMWV5C3 DI DMWV5C3 DMWV5C3 DN [3H]alphabeta-meATP DMWV5C3 MI TT38ECI DMWV5C3 MN Bacterial Hydroxymethyl-dihydropterin pyrophosphokinase (Bact folK) DMWV5C3 MT DTT DMWV5C3 MA Inhibitor DMWV5C3 RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMWV5C3 RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMWV5C3 DI DMWV5C3 DMWV5C3 DN [3H]alphabeta-meATP DMWV5C3 MI TT8WCXO DMWV5C3 MN Bacterial NH(3)-dependent NAD(+) synthetase (Bact nadE) DMWV5C3 MT DTT DMWV5C3 MA Inhibitor DMWV5C3 RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMWV5C3 RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMLF7SG DI DMLF7SG DMLF7SG DN [3H]AMPA DMLF7SG MI TTVPQTF DMLF7SG MN Glutamate receptor AMPA 1 (GRIA1) DMLF7SG MT DTT DMLF7SG MA Agonist DMLF7SG RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 444). DMLF7SG RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=444 DMLF7SG DI DMLF7SG DMLF7SG DN [3H]AMPA DMLF7SG MI TT9HLZ0 DMLF7SG MN Glutamate receptor AMPA 2 (GRIA2) DMLF7SG MT DTT DMLF7SG MA Agonist DMLF7SG RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 445). DMLF7SG RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=445 DMLF7SG DI DMLF7SG DMLF7SG DN [3H]AMPA DMLF7SG MI TT82EZV DMLF7SG MN Glutamate receptor AMPA 3 (GRIA3) DMLF7SG MT DTT DMLF7SG MA Modulator DMLF7SG RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 446). DMLF7SG RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=446 DMLF7SG DI DMLF7SG DMLF7SG DN [3H]AMPA DMLF7SG MI TTPJR0G DMLF7SG MN Glutamate receptor AMPA 4 (GRIA4) DMLF7SG MT DTT DMLF7SG MA Agonist DMLF7SG RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 447). DMLF7SG RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=447 DMPVG5Y DI DMPVG5Y DMPVG5Y DN [3H]AZ11637326 DMPVG5Y MI TTLA931 DMPVG5Y MN Neuronal acetylcholine receptor alpha-7 (CHRNA7) DMPVG5Y MT DTT DMPVG5Y MA Agonist DMPVG5Y RN In vitro binding characteristics of [3H]AZ11637326, a novel alpha7-selective neuronal nicotinic receptor agonist radioligand. Eur J Pharmacol. 2010 Oct 25;645(1-3):63-9. DMPVG5Y RU https://pubmed.ncbi.nlm.nih.gov/20674564 DMKL9X7 DI DMKL9X7 DMKL9X7 DN [3H]bag-2 DMKL9X7 MI TTHYDUM DMKL9X7 MN Bombesin receptor (BS) DMKL9X7 MT DTT DMKL9X7 MA Agonist DMKL9X7 RN Regulation of energy homeostasis by bombesin receptor subtype-3: selective receptor agonists for the treatment of obesity. Cell Metab. 2010 Feb 3;11(2):101-12. DMKL9X7 RU https://pubmed.ncbi.nlm.nih.gov/20096642 DMG8T3W DI DMG8T3W DMG8T3W DN [3H]BQ123 DMG8T3W MI TTKRD0G DMG8T3W MN Endothelin A receptor (EDNRA) DMG8T3W MT DTT DMG8T3W MA Antagonist DMG8T3W RN [3H]BQ-123, a highly specific and reversible radioligand for the endothelin ETA receptor subtype. Eur J Pharmacol. 1995 Feb 14;274(1-3):1-6. DMG8T3W RU https://pubmed.ncbi.nlm.nih.gov/7768260 DMZRQU7 DI DMZRQU7 DMZRQU7 DN [3H]cAMP DMZRQU7 MI TT2QM9D DMZRQU7 MN Adenylate cyclase (ADCY) DMZRQU7 MT DTT DMZRQU7 MA Inhibitor DMZRQU7 RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMZRQU7 RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMZRQU7 DI DMZRQU7 DMZRQU7 DN [3H]cAMP DMZRQU7 MI TTW4Y2M DMZRQU7 MN cAMP protein kinase type II-beta (PRKAR2B) DMZRQU7 MT DTT DMZRQU7 MA Inhibitor DMZRQU7 RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMZRQU7 RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMZRQU7 DI DMZRQU7 DMZRQU7 DN [3H]cAMP DMZRQU7 MI TTNAHEX DMZRQU7 MN cAMP-dependent protein kinase A type I (PRKAR1A) DMZRQU7 MT DTT DMZRQU7 MA Inhibitor DMZRQU7 RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMZRQU7 RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMZRQU7 DI DMZRQU7 DMZRQU7 DN [3H]cAMP DMZRQU7 MI TTYVI76 DMZRQU7 MN Fungal Protein kinase A (Fung ypkA) DMZRQU7 MT DTT DMZRQU7 MA Activator DMZRQU7 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1694). DMZRQU7 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1694 DMZRQU7 DI DMZRQU7 DMZRQU7 DN [3H]cAMP DMZRQU7 MI DTCSGPB DMZRQU7 MN Multidrug resistance-associated protein 4 (ABCC4) DMZRQU7 MT DTP DMZRQU7 MA Substrate DMZRQU7 RN cAMP regulates expression of the cyclic nucleotide transporter MRP4 (ABCC4) through the EPAC pathway. Pharmacogenet Genomics. 2014 Oct;24(10):522-6. DMZRQU7 RU http://www.ncbi.nlm.nih.gov/pubmed/25121519 DMZRQU7 DI DMZRQU7 DMZRQU7 DN [3H]cAMP DMZRQU7 MI DTYVM24 DMZRQU7 MN Multidrug resistance-associated protein 5 (ABCC5) DMZRQU7 MT DTP DMZRQU7 MA Substrate DMZRQU7 RN The multidrug resistance protein 5 functions as an ATP-dependent export pump for cyclic nucleotides. J Biol Chem. 2000 Sep 29;275(39):30069-74. DMZRQU7 RU http://www.ncbi.nlm.nih.gov/pubmed/10893247 DMZRQU7 DI DMZRQU7 DMZRQU7 DN [3H]cAMP DMZRQU7 MI DEON3ED DMZRQU7 MN Phosphodiesterase 7B (PDE7B) DMZRQU7 MT DME DMZRQU7 MA Metabolism DMZRQU7 RN Cloning and characterization of the human and mouse PDE7B, a novel cAMP-specific cyclic nucleotide phosphodiesterase. Biochem Biophys Res Commun. 2000 May 27;272(1):186-92. DMZRQU7 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=10872825 DMHDGB3 DI DMHDGB3 DMHDGB3 DN [3H]CCPA DMHDGB3 MI TTK25J1 DMHDGB3 MN Adenosine A1 receptor (ADORA1) DMHDGB3 MT DTT DMHDGB3 MA Agonist DMHDGB3 RN Comparative pharmacology of human adenosine receptor subtypes - characterization of stably transfected receptors in CHO cells. Naunyn Schmiedebergs Arch Pharmacol. 1998 Jan;357(1):1-9. DMHDGB3 RU https://pubmed.ncbi.nlm.nih.gov/9459566 DMHDGB3 DI DMHDGB3 DMHDGB3 DN [3H]CCPA DMHDGB3 MI TTM2AOE DMHDGB3 MN Adenosine A2a receptor (ADORA2A) DMHDGB3 MT DTT DMHDGB3 MA Inhibitor DMHDGB3 RN 5'-Carbamoyl derivatives of 2'-C-methyl-purine nucleosides as selective A1 adenosine receptor agonists: affinity, efficacy, and selectivity for A1 ... Bioorg Med Chem. 2008 Jan 1;16(1):336-53. DMHDGB3 RU https://pubmed.ncbi.nlm.nih.gov/17933541 DMHDGB3 DI DMHDGB3 DMHDGB3 DN [3H]CCPA DMHDGB3 MI TTNE7KG DMHDGB3 MN Adenosine A2b receptor (ADORA2B) DMHDGB3 MT DTT DMHDGB3 MA Inhibitor DMHDGB3 RN 5'-Carbamoyl derivatives of 2'-C-methyl-purine nucleosides as selective A1 adenosine receptor agonists: affinity, efficacy, and selectivity for A1 ... Bioorg Med Chem. 2008 Jan 1;16(1):336-53. DMHDGB3 RU https://pubmed.ncbi.nlm.nih.gov/17933541 DMHDGB3 DI DMHDGB3 DMHDGB3 DN [3H]CCPA DMHDGB3 MI TTJFY5U DMHDGB3 MN Adenosine A3 receptor (ADORA3) DMHDGB3 MT DTT DMHDGB3 MA Inhibitor DMHDGB3 RN 5'-Carbamoyl derivatives of 2'-C-methyl-purine nucleosides as selective A1 adenosine receptor agonists: affinity, efficacy, and selectivity for A1 ... Bioorg Med Chem. 2008 Jan 1;16(1):336-53. DMHDGB3 RU https://pubmed.ncbi.nlm.nih.gov/17933541 DMZN1A3 DI DMZN1A3 DMZN1A3 DN [3H]CGP12177 DMZN1A3 MI TTR6W5O DMZN1A3 MN Adrenergic receptor beta-1 (ADRB1) DMZN1A3 MT DTT DMZN1A3 MA Inhibitor DMZN1A3 RN (4-Piperidin-1-yl)phenyl amides: potent and selective human beta(3) agonists. J Med Chem. 2001 Apr 26;44(9):1456-66. DMZN1A3 RU https://pubmed.ncbi.nlm.nih.gov/11311069 DMZN1A3 DI DMZN1A3 DMZN1A3 DN [3H]CGP12177 DMZN1A3 MI TT2CJVK DMZN1A3 MN Adrenergic receptor beta-2 (ADRB2) DMZN1A3 MT DTT DMZN1A3 MA Inhibitor DMZN1A3 RN (4-Piperidin-1-yl)phenyl amides: potent and selective human beta(3) agonists. J Med Chem. 2001 Apr 26;44(9):1456-66. DMZN1A3 RU https://pubmed.ncbi.nlm.nih.gov/11311069 DMZN1A3 DI DMZN1A3 DMZN1A3 DN [3H]CGP12177 DMZN1A3 MI TTMXGCW DMZN1A3 MN Adrenergic receptor beta-3 (ADRB3) DMZN1A3 MT DTT DMZN1A3 MA Agonist DMZN1A3 RN Effects of several putative beta 3-adrenoceptor agonists on lipolysis in human omental adipocytes. Int J Obes Relat Metab Disord. 1996 May;20(5):428-34. DMZN1A3 RU https://pubmed.ncbi.nlm.nih.gov/8696421 DMQTBRM DI DMQTBRM DMQTBRM DN [3H]CGP27492 DMQTBRM MI TT1MPAY DMQTBRM MN GABA(A) receptor alpha-1 (GABRA1) DMQTBRM MT DTT DMQTBRM MA Inhibitor DMQTBRM RN Phosphinic acid analogues of GABA. 1. New potent and selective GABAB agonists. J Med Chem. 1995 Aug 18;38(17):3297-312. DMQTBRM RU https://pubmed.ncbi.nlm.nih.gov/7650684 DMQTBRM DI DMQTBRM DMQTBRM DN [3H]CGP27492 DMQTBRM MI TTDCVZW DMQTBRM MN Gamma-aminobutyric acid B receptor (GABBR) DMQTBRM MT DTT DMQTBRM MA Inhibitor DMQTBRM RN Biological activity of 3-aminopropyl (methyl) phosphinic acid, a potent and selective GABAB agonist with CNS activity, Bioorg. Med. Chem. Lett. 3(4):515-518 (1993). DMQTBRM RU http://www.sciencedirect.com/science/article/pii/S0960894X0181218X DMQTBRM DI DMQTBRM DMQTBRM DN [3H]CGP27492 DMQTBRM MI TTNJYV2 DMQTBRM MN Gamma-aminobutyric acid receptor (GAR) DMQTBRM MT DTT DMQTBRM MA Inhibitor DMQTBRM RN Phosphinic acid analogues of GABA. 1. New potent and selective GABAB agonists. J Med Chem. 1995 Aug 18;38(17):3297-312. DMQTBRM RU https://pubmed.ncbi.nlm.nih.gov/7650684 DMITR7A DI DMITR7A DMITR7A DN [3H]CGP39653 DMITR7A MI TTLD29N DMITR7A MN Glutamate receptor ionotropic NMDA 1 (NMDAR1) DMITR7A MT DTT DMITR7A MA Antagonist DMITR7A RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 455). DMITR7A RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=455 DMITR7A DI DMITR7A DMITR7A DN [3H]CGP39653 DMITR7A MI TTKJEMQ DMITR7A MN Glutamate receptor ionotropic NMDA 2A (NMDAR2A) DMITR7A MT DTT DMITR7A MA Antagonist DMITR7A RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 456). DMITR7A RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=456 DMITR7A DI DMITR7A DMITR7A DN [3H]CGP39653 DMITR7A MI TTN9D8E DMITR7A MN Glutamate receptor ionotropic NMDA 2B (NMDAR2B) DMITR7A MT DTT DMITR7A MA Antagonist DMITR7A RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 457). DMITR7A RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=457 DMITR7A DI DMITR7A DMITR7A DN [3H]CGP39653 DMITR7A MI TT1M8OW DMITR7A MN Glutamate receptor ionotropic NMDA 2C (GluN2C) DMITR7A MT DTT DMITR7A MA Antagonist DMITR7A RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 458). DMITR7A RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=458 DMITR7A DI DMITR7A DMITR7A DN [3H]CGP39653 DMITR7A MI TT5POTG DMITR7A MN Glutamate receptor ionotropic NMDA 2D (GluN2D) DMITR7A MT DTT DMITR7A MA Antagonist DMITR7A RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 459). DMITR7A RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=459 DM7H3JN DI DM7H3JN DM7H3JN DN [3H]CGS19755 DM7H3JN MI TTLD29N DM7H3JN MN Glutamate receptor ionotropic NMDA 1 (NMDAR1) DM7H3JN MT DTT DM7H3JN MA Antagonist DM7H3JN RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 455). DM7H3JN RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=455 DM7H3JN DI DM7H3JN DM7H3JN DN [3H]CGS19755 DM7H3JN MI TTKJEMQ DM7H3JN MN Glutamate receptor ionotropic NMDA 2A (NMDAR2A) DM7H3JN MT DTT DM7H3JN MA Antagonist DM7H3JN RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 456). DM7H3JN RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=456 DM7H3JN DI DM7H3JN DM7H3JN DN [3H]CGS19755 DM7H3JN MI TTN9D8E DM7H3JN MN Glutamate receptor ionotropic NMDA 2B (NMDAR2B) DM7H3JN MT DTT DM7H3JN MA Antagonist DM7H3JN RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 457). DM7H3JN RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=457 DM7H3JN DI DM7H3JN DM7H3JN DN [3H]CGS19755 DM7H3JN MI TT1M8OW DM7H3JN MN Glutamate receptor ionotropic NMDA 2C (GluN2C) DM7H3JN MT DTT DM7H3JN MA Antagonist DM7H3JN RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 458). DM7H3JN RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=458 DM7H3JN DI DM7H3JN DM7H3JN DN [3H]CGS19755 DM7H3JN MI TT5POTG DM7H3JN MN Glutamate receptor ionotropic NMDA 2D (GluN2D) DM7H3JN MT DTT DM7H3JN MA Antagonist DM7H3JN RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 459). DM7H3JN RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=459 DMLP68J DI DMLP68J DMLP68J DN [3H]CGS8216 DMLP68J MI TT1MPAY DMLP68J MN GABA(A) receptor alpha-1 (GABRA1) DMLP68J MT DTT DMLP68J MA Inhibitor DMLP68J RN Synthesis and benzodiazepine binding activity of a series of novel [1,2,4]triazolo[1,5-c]quinazolin-5(6H)-ones. J Med Chem. 1991 Jan;34(1):281-90. DMLP68J RU https://pubmed.ncbi.nlm.nih.gov/1846920 DMLP68J DI DMLP68J DMLP68J DN [3H]CGS8216 DMLP68J MI TTBMV1G DMLP68J MN GABA(A) receptor alpha-2 (GABRA2) DMLP68J MT DTT DMLP68J MA Modulator (allosteric modulator) DMLP68J RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 405). DMLP68J RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=405 DMLP68J DI DMLP68J DMLP68J DN [3H]CGS8216 DMLP68J MI TT37EDJ DMLP68J MN GABA(A) receptor alpha-3 (GABRA3) DMLP68J MT DTT DMLP68J MA Modulator (allosteric modulator) DMLP68J RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 406). DMLP68J RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=406 DMLP68J DI DMLP68J DMLP68J DN [3H]CGS8216 DMLP68J MI TTNZPQ1 DMLP68J MN GABA(A) receptor alpha-5 (GABRA5) DMLP68J MT DTT DMLP68J MA Modulator (allosteric modulator) DMLP68J RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 408). DMLP68J RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=408 DMLP68J DI DMLP68J DMLP68J DN [3H]CGS8216 DMLP68J MI TTZA1NY DMLP68J MN GABA(A) receptor beta-2 (GABRB2) DMLP68J MT DTT DMLP68J MA Inhibitor DMLP68J RN Substituted 3-(2-benzoxazyl)-benzimidazol-2-(1H)-ones: a new class of GABA(A) brain receptor ligands. Bioorg Med Chem Lett. 2000 Dec 18;10(24):2723-6. DMLP68J RU https://pubmed.ncbi.nlm.nih.gov/11133077 DMLP68J DI DMLP68J DMLP68J DN [3H]CGS8216 DMLP68J MI TT06RH5 DMLP68J MN GABA(A) receptor gamma-2 (GABRG2) DMLP68J MT DTT DMLP68J MA Inhibitor DMLP68J RN Synthesis and benzodiazepine binding activity of a series of novel [1,2,4]triazolo[1,5-c]quinazolin-5(6H)-ones. J Med Chem. 1991 Jan;34(1):281-90. DMLP68J RU https://pubmed.ncbi.nlm.nih.gov/1846920 DMLP68J DI DMLP68J DMLP68J DN [3H]CGS8216 DMLP68J MI TTEX6LM DMLP68J MN GABA(A) receptor gamma-3 (GABRG3) DMLP68J MT DTT DMLP68J MA Modulator (allosteric modulator) DMLP68J RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 415). DMLP68J RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=415 DMLP68J DI DMLP68J DMLP68J DN [3H]CGS8216 DMLP68J MI TTNJYV2 DMLP68J MN Gamma-aminobutyric acid receptor (GAR) DMLP68J MT DTT DMLP68J MA Inhibitor DMLP68J RN Synthesis and benzodiazepine binding activity of a series of novel [1,2,4]triazolo[1,5-c]quinazolin-5(6H)-ones. J Med Chem. 1991 Jan;34(1):281-90. DMLP68J RU https://pubmed.ncbi.nlm.nih.gov/1846920 DMIFKUX DI DMIFKUX DMIFKUX DN [3H]CNQX DMIFKUX MI TTAN6JD DMIFKUX MN Glutamate receptor AMPA (GRIA) DMIFKUX MT DTT DMIFKUX MA Inhibitor DMIFKUX RN Structure-activity relationship studies on N3-substituted willardiine derivatives acting as AMPA or kainate receptor antagonists. J Med Chem. 2006 Apr 20;49(8):2579-92. DMIFKUX RU https://pubmed.ncbi.nlm.nih.gov/16610801 DMIFKUX DI DMIFKUX DMIFKUX DN [3H]CNQX DMIFKUX MI TTVPQTF DMIFKUX MN Glutamate receptor AMPA 1 (GRIA1) DMIFKUX MT DTT DMIFKUX MA Antagonist DMIFKUX RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 444). DMIFKUX RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=444 DMIFKUX DI DMIFKUX DMIFKUX DN [3H]CNQX DMIFKUX MI TT9HLZ0 DMIFKUX MN Glutamate receptor AMPA 2 (GRIA2) DMIFKUX MT DTT DMIFKUX MA Antagonist DMIFKUX RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 445). DMIFKUX RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=445 DMIFKUX DI DMIFKUX DMIFKUX DN [3H]CNQX DMIFKUX MI TT82EZV DMIFKUX MN Glutamate receptor AMPA 3 (GRIA3) DMIFKUX MT DTT DMIFKUX MA Modulator DMIFKUX RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 446). DMIFKUX RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=446 DMIFKUX DI DMIFKUX DMIFKUX DN [3H]CNQX DMIFKUX MI TTPJR0G DMIFKUX MN Glutamate receptor AMPA 4 (GRIA4) DMIFKUX MT DTT DMIFKUX MA Modulator DMIFKUX RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 447). DMIFKUX RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=447 DMU7FC5 DI DMU7FC5 DMU7FC5 DN [3H]CP55940 DMU7FC5 MI TT6OEDT DMU7FC5 MN Cannabinoid receptor 1 (CB1) DMU7FC5 MT DTT DMU7FC5 MA Agonist DMU7FC5 RN Structural features of the central cannabinoid CB1 receptor involved in the binding of the specific CB1 antagonist SR 141716A. J Biol Chem. 1996 Mar 22;271(12):6941-6. DMU7FC5 RU https://pubmed.ncbi.nlm.nih.gov/8636122 DMU7FC5 DI DMU7FC5 DMU7FC5 DN [3H]CP55940 DMU7FC5 MI TTMSFAW DMU7FC5 MN Cannabinoid receptor 2 (CB2) DMU7FC5 MT DTT DMU7FC5 MA Agonist DMU7FC5 RN Signaling pathway associated with stimulation of CB2 peripheral cannabinoid receptor. Involvement of both mitogen-activated protein kinase and induction of Krox-24 expression. Eur J Biochem. 1996 May1;237(3):704-11. DMU7FC5 RU https://pubmed.ncbi.nlm.nih.gov/8647116 DMU7FC5 DI DMU7FC5 DMU7FC5 DN [3H]CP55940 DMU7FC5 MI TTNET8J DMU7FC5 MN G-protein coupled receptor 55 (GPR55) DMU7FC5 MT DTT DMU7FC5 MA Agonist DMU7FC5 RN The orphan receptor GPR55 is a novel cannabinoid receptor. Br J Pharmacol. 2007 Dec;152(7):1092-101. DMU7FC5 RU https://pubmed.ncbi.nlm.nih.gov/17876302 DMR5UBF DI DMR5UBF DMR5UBF DN [3H]CPP DMR5UBF MI TTLD29N DMR5UBF MN Glutamate receptor ionotropic NMDA 1 (NMDAR1) DMR5UBF MT DTT DMR5UBF MA Antagonist DMR5UBF RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 455). DMR5UBF RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=455 DMR5UBF DI DMR5UBF DMR5UBF DN [3H]CPP DMR5UBF MI TTKJEMQ DMR5UBF MN Glutamate receptor ionotropic NMDA 2A (NMDAR2A) DMR5UBF MT DTT DMR5UBF MA Antagonist DMR5UBF RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 456). DMR5UBF RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=456 DMR5UBF DI DMR5UBF DMR5UBF DN [3H]CPP DMR5UBF MI TTN9D8E DMR5UBF MN Glutamate receptor ionotropic NMDA 2B (NMDAR2B) DMR5UBF MT DTT DMR5UBF MA Antagonist DMR5UBF RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 457). DMR5UBF RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=457 DMR5UBF DI DMR5UBF DMR5UBF DN [3H]CPP DMR5UBF MI TT1M8OW DMR5UBF MN Glutamate receptor ionotropic NMDA 2C (GluN2C) DMR5UBF MT DTT DMR5UBF MA Antagonist DMR5UBF RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 458). DMR5UBF RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=458 DMR5UBF DI DMR5UBF DMR5UBF DN [3H]CPP DMR5UBF MI TT5POTG DMR5UBF MN Glutamate receptor ionotropic NMDA 2D (GluN2D) DMR5UBF MT DTT DMR5UBF MA Antagonist DMR5UBF RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 459). DMR5UBF RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=459 DMVLRHW DI DMVLRHW DMVLRHW DN [3H]cytisine DMVLRHW MI TTH18TF DMVLRHW MN Muscarinic acetylcholine receptor M5 (CHRM5) DMVLRHW MT DTT DMVLRHW MA Agonist DMVLRHW RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 467). DMVLRHW RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=467 DMVLRHW DI DMVLRHW DMVLRHW DN [3H]cytisine DMVLRHW MI TTF4E0J DMVLRHW MN Neuronal acetylcholine receptor alpha-2 (CHRNA2) DMVLRHW MT DTT DMVLRHW MA Agonist DMVLRHW RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 463). DMVLRHW RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=463 DMVLRHW DI DMVLRHW DMVLRHW DN [3H]cytisine DMVLRHW MI TT5KPZR DMVLRHW MN Neuronal acetylcholine receptor beta-2 (CHRNB2) DMVLRHW MT DTT DMVLRHW MA Agonist DMVLRHW RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 465). DMVLRHW RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=465 DM4NXRO DI DM4NXRO DM4NXRO DN [3H]devazepide DM4NXRO MI TTCG0AL DM4NXRO MN Cholecystokinin receptor type A (CCKAR) DM4NXRO MT DTT DM4NXRO MA Antagonist DM4NXRO RN Characterization of the binding of [3H]-(+/-)-L-364,718: a new potent, nonpeptide cholecystokinin antagonist radioligand selective for peripheral receptors. Mol Pharmacol. 1986 Sep;30(3):212-7. DM4NXRO RU https://pubmed.ncbi.nlm.nih.gov/3018478 DMBWAIE DI DMBWAIE DMBWAIE DN [3H]dimethyl-W84 DMBWAIE MI TTOXS3C DMBWAIE MN Muscarinic acetylcholine receptor (CHRM) DMBWAIE MT DTT DMBWAIE MA Modulator (allosteric modulator) DMBWAIE RN Interactions of orthosteric and allosteric ligands with [3H]dimethyl-W84 at the common allosteric site of muscarinic M2 receptors. Mol Pharmacol. 2003 Jul;64(1):180-90. DMBWAIE RU https://pubmed.ncbi.nlm.nih.gov/12815174 DMBMS1U DI DMBMS1U DMBMS1U DN [3H]diprenorphine DMBMS1U MI TT27RFC DMBMS1U MN Opioid receptor delta (OPRD1) DMBMS1U MT DTT DMBMS1U MA Agonist DMBMS1U RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 317). DMBMS1U RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=317 DMBMS1U DI DMBMS1U DMBMS1U DN [3H]diprenorphine DMBMS1U MI TTQW87Y DMBMS1U MN Opioid receptor kappa (OPRK1) DMBMS1U MT DTT DMBMS1U MA Antagonist DMBMS1U RN kappa-Opioid receptor in humans: cDNA and genomic cloning, chromosomal assignment, functional expression, pharmacology, and expression pattern in the central nervous system. Proc Natl Acad Sci U S A.1995 Jul 18;92(15):7006-10. DMBMS1U RU https://pubmed.ncbi.nlm.nih.gov/7624359 DMBMS1U DI DMBMS1U DMBMS1U DN [3H]diprenorphine DMBMS1U MI TTKWM86 DMBMS1U MN Opioid receptor mu (MOP) DMBMS1U MT DTT DMBMS1U MA Antagonist DMBMS1U RN Pharmacological characterization of the cloned kappa-, delta-, and mu-opioid receptors. Mol Pharmacol. 1994 Feb;45(2):330-4. DMBMS1U RU https://pubmed.ncbi.nlm.nih.gov/8114680 DMEC2PF DI DMEC2PF DMEC2PF DN [3H]dizocilpine DMEC2PF MI TTLD29N DMEC2PF MN Glutamate receptor ionotropic NMDA 1 (NMDAR1) DMEC2PF MT DTT DMEC2PF MA Antagonist DMEC2PF RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 455). DMEC2PF RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=455 DMEC2PF DI DMEC2PF DMEC2PF DN [3H]dizocilpine DMEC2PF MI TTKJEMQ DMEC2PF MN Glutamate receptor ionotropic NMDA 2A (NMDAR2A) DMEC2PF MT DTT DMEC2PF MA Blocker (channel blocker) DMEC2PF RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 456). DMEC2PF RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=456 DMEC2PF DI DMEC2PF DMEC2PF DN [3H]dizocilpine DMEC2PF MI TTN9D8E DMEC2PF MN Glutamate receptor ionotropic NMDA 2B (NMDAR2B) DMEC2PF MT DTT DMEC2PF MA Blocker (channel blocker) DMEC2PF RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 457). DMEC2PF RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=457 DMEC2PF DI DMEC2PF DMEC2PF DN [3H]dizocilpine DMEC2PF MI TT1M8OW DMEC2PF MN Glutamate receptor ionotropic NMDA 2C (GluN2C) DMEC2PF MT DTT DMEC2PF MA Blocker (channel blocker) DMEC2PF RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 458). DMEC2PF RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=458 DMEC2PF DI DMEC2PF DMEC2PF DN [3H]dizocilpine DMEC2PF MI TT5POTG DMEC2PF MN Glutamate receptor ionotropic NMDA 2D (GluN2D) DMEC2PF MT DTT DMEC2PF MA Blocker (channel blocker) DMEC2PF RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 459). DMEC2PF RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=459 DM9GY7O DI DM9GY7O DM9GY7O DN [3H]DPCPX DM9GY7O MI TTK25J1 DM9GY7O MN Adenosine A1 receptor (ADORA1) DM9GY7O MT DTT DM9GY7O MA Antagonist DM9GY7O RN Inhibition of human mast cell activation with the novel selective adenosine A(2B) receptor antagonist 3-isobutyl-8-pyrrolidinoxanthine (IPDX)(2). Biochem Pharmacol. 2001 Nov 1;62(9):1163-73. DM9GY7O RU https://pubmed.ncbi.nlm.nih.gov/11705449 DM9GY7O DI DM9GY7O DM9GY7O DN [3H]DPCPX DM9GY7O MI TTNE7KG DM9GY7O MN Adenosine A2b receptor (ADORA2B) DM9GY7O MT DTT DM9GY7O MA Antagonist DM9GY7O RN [3H]OSIP339391, a selective, novel, and high affinity antagonist radioligand for adenosine A2B receptors. Biochem Pharmacol. 2004 Jul 15;68(2):305-12. DM9GY7O RU https://pubmed.ncbi.nlm.nih.gov/15194002 DMDTYRV DI DMDTYRV DMDTYRV DN [3H]eletriptan DMDTYRV MI TTK8CXU DMDTYRV MN 5-HT 1B receptor (HTR1B) DMDTYRV MT DTT DMDTYRV MA Agonist DMDTYRV RN Characterisation of the 5-HT receptor binding profile of eletriptan and kinetics of [3H]eletriptan binding at human 5-HT1B and 5-HT1D receptors. Eur J Pharmacol. 1999 Mar 5;368(2-3):259-68. DMDTYRV RU https://pubmed.ncbi.nlm.nih.gov/10193663 DMDTYRV DI DMDTYRV DMDTYRV DN [3H]eletriptan DMDTYRV MI TT6MSOK DMDTYRV MN 5-HT 1D receptor (HTR1D) DMDTYRV MT DTT DMDTYRV MA Agonist DMDTYRV RN Characterisation of the 5-HT receptor binding profile of eletriptan and kinetics of [3H]eletriptan binding at human 5-HT1B and 5-HT1D receptors. Eur J Pharmacol. 1999 Mar 5;368(2-3):259-68. DMDTYRV RU https://pubmed.ncbi.nlm.nih.gov/10193663 DMM1KBW DI DMM1KBW DMM1KBW DN [3H]EM-TBPC DMM1KBW MI TTVBPDM DMM1KBW MN Metabotropic glutamate receptor 1 (mGluR1) DMM1KBW MT DTT DMM1KBW MA Modulator (allosteric modulator) DMM1KBW RN Mutational analysis and molecular modeling of the allosteric binding site of a novel, selective, noncompetitive antagonist of the metabotropic glut... J Biol Chem. 2003 Mar 7;278(10):8340-7. DMM1KBW RU https://pubmed.ncbi.nlm.nih.gov/12509432 DM3KJ45 DI DM3KJ45 DM3KJ45 DN [3H]estradiol-17beta-glucuronide DM3KJ45 MI DTI7UX6 DM3KJ45 MN Breast cancer resistance protein (ABCG2) DM3KJ45 MT DTP DM3KJ45 MA Substrate DM3KJ45 RN Regulation of the function of the human ABCG2 multidrug transporter by cholesterol and bile acids: effects of mutations in potential substrate and steroid binding sites. Drug Metab Dispos. 2014 Apr;42(4):575-85. DM3KJ45 RU http://www.ncbi.nlm.nih.gov/pubmed/24384916 DM3KJ45 DI DM3KJ45 DM3KJ45 DN [3H]estradiol-17beta-glucuronide DM3KJ45 MI TTFGXEB DM3KJ45 MN Liver organic anion transporter 1 (SLCO1B1) DM3KJ45 MT DTT DM3KJ45 MA Modulator DM3KJ45 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1220). DM3KJ45 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1220 DM3KJ45 DI DM3KJ45 DM3KJ45 DN [3H]estradiol-17beta-glucuronide DM3KJ45 MI TTU86P0 DM3KJ45 MN Liver organic anion transporter 2 (SLCO1B3) DM3KJ45 MT DTT DM3KJ45 MA Modulator DM3KJ45 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1221). DM3KJ45 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1221 DM3KJ45 DI DM3KJ45 DM3KJ45 DN [3H]estradiol-17beta-glucuronide DM3KJ45 MI DTSYQGK DM3KJ45 MN Multidrug resistance-associated protein 1 (ABCC1) DM3KJ45 MT DTP DM3KJ45 MA Substrate DM3KJ45 RN Drug resistance and ATP-dependent conjugate transport mediated by the apical multidrug resistance protein, MRP2, permanently expressed in human and canine cells. Mol Pharmacol. 1999 May;55(5):929-37. DM3KJ45 RU http://www.ncbi.nlm.nih.gov/pubmed/10220572 DM3KJ45 DI DM3KJ45 DM3KJ45 DN [3H]estradiol-17beta-glucuronide DM3KJ45 MI DTFI42L DM3KJ45 MN Multidrug resistance-associated protein 2 (ABCC2) DM3KJ45 MT DTP DM3KJ45 MA Substrate DM3KJ45 RN Drug resistance and ATP-dependent conjugate transport mediated by the apical multidrug resistance protein, MRP2, permanently expressed in human and canine cells. Mol Pharmacol. 1999 May;55(5):929-37. DM3KJ45 RU http://www.ncbi.nlm.nih.gov/pubmed/10220572 DM3KJ45 DI DM3KJ45 DM3KJ45 DN [3H]estradiol-17beta-glucuronide DM3KJ45 MI DTQ3ZHF DM3KJ45 MN Multidrug resistance-associated protein 3 (ABCC3) DM3KJ45 MT DTP DM3KJ45 MA Substrate DM3KJ45 RN Characterization of the role of polar amino acid residues within predicted transmembrane helix 17 in determining the substrate specificity of multidrug resistance protein 3. Biochemistry. 2003 Aug 26;42(33):9989-10000. DM3KJ45 RU http://www.ncbi.nlm.nih.gov/pubmed/12924948 DM3KJ45 DI DM3KJ45 DM3KJ45 DN [3H]estradiol-17beta-glucuronide DM3KJ45 MI DTCSGPB DM3KJ45 MN Multidrug resistance-associated protein 4 (ABCC4) DM3KJ45 MT DTP DM3KJ45 MA Substrate DM3KJ45 RN Multidrug resistance-associated proteins 3, 4, and 5. Pflugers Arch. 2007 Feb;453(5):661-73. DM3KJ45 RU http://www.ncbi.nlm.nih.gov/pubmed/16586096 DM3KJ45 DI DM3KJ45 DM3KJ45 DN [3H]estradiol-17beta-glucuronide DM3KJ45 MI DTE2B1D DM3KJ45 MN Organic anion transporting polypeptide 1A2 (SLCO1A2) DM3KJ45 MT DTP DM3KJ45 MA Substrate DM3KJ45 RN Regulation of renal oatp mRNA expression by testosterone. Am J Physiol. 1996 Feb;270(2 Pt 2):F332-7. DM3KJ45 RU http://www.ncbi.nlm.nih.gov/pubmed/8779895 DM3KJ45 DI DM3KJ45 DM3KJ45 DN [3H]estradiol-17beta-glucuronide DM3KJ45 MI DT3D8F0 DM3KJ45 MN Organic anion transporting polypeptide 1B1 (SLCO1B1) DM3KJ45 MT DTP DM3KJ45 MA Substrate DM3KJ45 RN Identification, Ki determination and CoMFA analysis of nuclear receptor ligands as competitive inhibitors of OATP1B1-mediated estradiol-17beta-glucuronide transport. Pharmacol Res. 2009 Jul;60(1):50-6. DM3KJ45 RU http://www.ncbi.nlm.nih.gov/pubmed/19427586 DM3KJ45 DI DM3KJ45 DM3KJ45 DN [3H]estradiol-17beta-glucuronide DM3KJ45 MI DT9C1TS DM3KJ45 MN Organic anion transporting polypeptide 1B3 (SLCO1B3) DM3KJ45 MT DTP DM3KJ45 MA Substrate DM3KJ45 RN Interactions of green tea catechins with organic anion-transporting polypeptides. Drug Metab Dispos. 2011 May;39(5):920-6. DM3KJ45 RU http://www.ncbi.nlm.nih.gov/pubmed/21278283 DM3KJ45 DI DM3KJ45 DM3KJ45 DN [3H]estradiol-17beta-glucuronide DM3KJ45 MI DTPYCQ4 DM3KJ45 MN Organic anion transporting polypeptide 1C1 (SLCO1C1) DM3KJ45 MT DTP DM3KJ45 MA Substrate DM3KJ45 RN The blood-brain barrier thyroxine transporter organic anion-transporting polypeptide 1c1 displays atypical transport kinetics. Endocrinology. 2009 Nov;150(11):5153-62. DM3KJ45 RU http://www.ncbi.nlm.nih.gov/pubmed/19819953 DMGPF0N DI DMGPF0N DMGPF0N DN [3H]estrone-3-sulphate DMGPF0N MI DEJGDUW DMGPF0N MN Cytochrome P450 1A2 (CYP1A2) DMGPF0N MT DME DMGPF0N MA Metabolism DMGPF0N RN Role of polymorphic human cytochrome P450 enzymes in estrone oxidation. Cancer Epidemiol Biomarkers Prev. 2006 Mar;15(3):551-8. DMGPF0N RU https://www.ncbi.nlm.nih.gov/pubmed/?term=16537715 DMGPF0N DI DMGPF0N DMGPF0N DN [3H]estrone-3-sulphate DMGPF0N MI DE5IED8 DMGPF0N MN Cytochrome P450 2C9 (CYP2C9) DMGPF0N MT DME DMGPF0N MA Metabolism DMGPF0N RN Pharmacogenomics of CYP2C9: functional and clinical considerations. J Pers Med. 2017 Dec 28;8(1). DMGPF0N RU https://www.ncbi.nlm.nih.gov/pubmed/?term=29283396 DMGPF0N DI DMGPF0N DMGPF0N DN [3H]estrone-3-sulphate DMGPF0N MI DE4LYSA DMGPF0N MN Cytochrome P450 3A4 (CYP3A4) DMGPF0N MT DME DMGPF0N MA Metabolism DMGPF0N RN Estrogen regulation of the cytochrome P450 3A subfamily in humans. J Pharmacol Exp Ther. 2004 Nov;311(2):728-35. DMGPF0N RU https://www.ncbi.nlm.nih.gov/pubmed/?term=15282264 DMGPF0N DI DMGPF0N DMGPF0N DN [3H]estrone-3-sulphate DMGPF0N MI TTFGXEB DMGPF0N MN Liver organic anion transporter 1 (SLCO1B1) DMGPF0N MT DTT DMGPF0N MA Modulator DMGPF0N RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1220). DMGPF0N RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1220 DMGPF0N DI DMGPF0N DMGPF0N DN [3H]estrone-3-sulphate DMGPF0N MI TTDL3UZ DMGPF0N MN Organic anion transporter B (SLCO2B1) DMGPF0N MT DTT DMGPF0N MA Modulator DMGPF0N RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1224). DMGPF0N RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1224 DMGPF0N DI DMGPF0N DMGPF0N DN [3H]estrone-3-sulphate DMGPF0N MI TT5CE6L DMGPF0N MN Organic anion transporter D (SLCO3A1) DMGPF0N MT DTT DMGPF0N MA Modulator DMGPF0N RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1225). DMGPF0N RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1225 DMGPF0N DI DMGPF0N DMGPF0N DN [3H]estrone-3-sulphate DMGPF0N MI TTV1YIE DMGPF0N MN Organic anion transporter E (SLCO4A1) DMGPF0N MT DTT DMGPF0N MA Modulator DMGPF0N RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1226). DMGPF0N RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1226 DMGPF0N DI DMGPF0N DMGPF0N DN [3H]estrone-3-sulphate DMGPF0N MI TT340CE DMGPF0N MN Organic anion transporter F (SLCO1C1) DMGPF0N MT DTT DMGPF0N MA Modulator DMGPF0N RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1222). DMGPF0N RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1222 DMGPF0N DI DMGPF0N DMGPF0N DN [3H]estrone-3-sulphate DMGPF0N MI TTUGD21 DMGPF0N MN Sodium-independent organic anion transporter (SLCO1A2) DMGPF0N MT DTT DMGPF0N MA Modulator DMGPF0N RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1219). DMGPF0N RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1219 DMGPF0N DI DMGPF0N DMGPF0N DN [3H]estrone-3-sulphate DMGPF0N MI DE7WRSB DMGPF0N MN Sulfatase (sulF) DMGPF0N MT DME DMGPF0N MA Metabolism DMGPF0N RN Parabacteroides pacaensis sp. nov. and Parabacteroides provencensis sp. nov., two new species identified from human gut microbiota. New Microbes New Infect. 2020 Jan 7;34:100642. DMGPF0N RU https://pubmed.ncbi.nlm.nih.gov/32071723 DMGPF0N DI DMGPF0N DMGPF0N DN [3H]estrone-3-sulphate DMGPF0N MI DE9THM7 DMGPF0N MN Sulfatase (sulF) DMGPF0N MT DME DMGPF0N MA Metabolism DMGPF0N RN Two rheumatoid arthritis-specific autoantigens correlate microbial immunity with autoimmune responses in joints. J Clin Invest. 2017 Aug 1;127(8):2946-2956. DMGPF0N RU https://pubmed.ncbi.nlm.nih.gov/28650341 DMGPF0N DI DMGPF0N DMGPF0N DN [3H]estrone-3-sulphate DMGPF0N MI DE10BJ5 DMGPF0N MN Tyrosine-protein phosphatase STS1/TULA2 (UBASH3B) DMGPF0N MT DME DMGPF0N MA Metabolism DMGPF0N RN Steroid sulfatase: a pivotal player in estrogen synthesis and metabolism. Mol Cell Endocrinol. 2011 Jul 4;340(2):154-60. DMGPF0N RU https://www.ncbi.nlm.nih.gov/pubmed/?term=21693170 DMWGY61 DI DMWGY61 DMWGY61 DN [3H]ETB-TBOA DMWGY61 MI TT8WRDA DMWGY61 MN Excitatory amino acid transporter 1 (SLC1A3) DMWGY61 MT DTT DMWGY61 MA Modulator DMWGY61 RN Characterization of the tritium-labeled analog of L-threo-beta-benzyloxyaspartate binding to glutamate transporters. Mol Pharmacol. 2007 Jan;71(1):294-302. DMWGY61 RU https://pubmed.ncbi.nlm.nih.gov/17047096 DMWGY61 DI DMWGY61 DMWGY61 DN [3H]ETB-TBOA DMWGY61 MI TT2F078 DMWGY61 MN Excitatory amino acid transporter 2 (SLC1A2) DMWGY61 MT DTT DMWGY61 MA Modulator DMWGY61 RN Characterization of the tritium-labeled analog of L-threo-beta-benzyloxyaspartate binding to glutamate transporters. Mol Pharmacol. 2007 Jan;71(1):294-302. DMWGY61 RU https://pubmed.ncbi.nlm.nih.gov/17047096 DMWGY61 DI DMWGY61 DMWGY61 DN [3H]ETB-TBOA DMWGY61 MI TTG2A6F DMWGY61 MN Excitatory amino acid transporter 3 (SLC1A1) DMWGY61 MT DTT DMWGY61 MA Modulator DMWGY61 RN Characterization of the tritium-labeled analog of L-threo-beta-benzyloxyaspartate binding to glutamate transporters. Mol Pharmacol. 2007 Jan;71(1):294-302. DMWGY61 RU https://pubmed.ncbi.nlm.nih.gov/17047096 DMWGY61 DI DMWGY61 DMWGY61 DN [3H]ETB-TBOA DMWGY61 MI TT6KMPN DMWGY61 MN Excitatory amino acid transporter 4 (SLC1A6) DMWGY61 MT DTT DMWGY61 MA Modulator DMWGY61 RN Characterization of the tritium-labeled analog of L-threo-beta-benzyloxyaspartate binding to glutamate transporters. Mol Pharmacol. 2007 Jan;71(1):294-302. DMWGY61 RU https://pubmed.ncbi.nlm.nih.gov/17047096 DMWGY61 DI DMWGY61 DMWGY61 DN [3H]ETB-TBOA DMWGY61 MI TTK41DM DMWGY61 MN Excitatory amino acid transporter 5 (SLC1A7) DMWGY61 MT DTT DMWGY61 MA Modulator DMWGY61 RN Characterization of the tritium-labeled analog of L-threo-beta-benzyloxyaspartate binding to glutamate transporters. Mol Pharmacol. 2007 Jan;71(1):294-302. DMWGY61 RU https://pubmed.ncbi.nlm.nih.gov/17047096 DME0XHN DI DME0XHN DME0XHN DN [3H]folinic acid DME0XHN MI TTY8Z2E DME0XHN MN Proton-coupled folate transporter (SLC46A1) DME0XHN MT DTT DME0XHN MA Modulator DME0XHN RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1213). DME0XHN RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1213 DMGQDLU DI DMGQDLU DMGQDLU DN [3H]GBR12935 DMGQDLU MI TT8DBY3 DMGQDLU MN Angiotensin II receptor type-1 (AGTR1) DMGQDLU MT DTT DMGQDLU MA Antagonist DMGQDLU RN Specific binding of 1-[2-(diphenylmethoxy)ethyl]-4-(3-phenyl propyl) piperazine (GBR-12935), an inhibitor of the dopamine transporter, to human CYP2D6. Biochem Pharmacol. 1997 Jun 15;53(12):1937-9. DMGQDLU RU https://pubmed.ncbi.nlm.nih.gov/9256169 DMGQDLU DI DMGQDLU DMGQDLU DN [3H]GBR12935 DMGQDLU MI TTVBI8W DMGQDLU MN Dopamine transporter (DAT) DMGQDLU MT DTT DMGQDLU MA Inhibitor DMGQDLU RN Pharmacological heterogeneity of the cloned and native human dopamine transporter: disassociation of [3H]WIN 35,428 and [3H]GBR 12,935 binding. Mol Pharmacol. 1994 Jan;45(1):125-35. DMGQDLU RU https://pubmed.ncbi.nlm.nih.gov/8302271 DMFEYLS DI DMFEYLS DMFEYLS DN [3H]GlySar DMFEYLS MI TT5LF3C DMFEYLS MN Solute carrier family 15 member 1 (SLC15A1) DMFEYLS MT DTT DMFEYLS MA Modulator DMFEYLS RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 984). DMFEYLS RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=984 DMFEYLS DI DMFEYLS DMFEYLS DN [3H]GlySar DMFEYLS MI TT27Q3A DMFEYLS MN Solute carrier family 15 member 2 (SLC15A2) DMFEYLS MT DTT DMFEYLS MA Modulator DMFEYLS RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 985). DMFEYLS RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=985 DM4URBO DI DM4URBO DM4URBO DN [3H]GR 125,743 DM4URBO MI TTK8CXU DM4URBO MN 5-HT 1B receptor (HTR1B) DM4URBO MT DTT DM4URBO MA Antagonist DM4URBO RN Serotonin 5-HT1B and 5-HT1D receptors form homodimers when expressed alone and heterodimers when co-expressed. FEBS Lett. 1999 Jul 30;456(1):63-7. DM4URBO RU https://pubmed.ncbi.nlm.nih.gov/10452531 DM4URBO DI DM4URBO DM4URBO DN [3H]GR 125,743 DM4URBO MI TT6MSOK DM4URBO MN 5-HT 1D receptor (HTR1D) DM4URBO MT DTT DM4URBO MA Antagonist DM4URBO RN Serotonin 5-HT1B and 5-HT1D receptors form homodimers when expressed alone and heterodimers when co-expressed. FEBS Lett. 1999 Jul 30;456(1):63-7. DM4URBO RU https://pubmed.ncbi.nlm.nih.gov/10452531 DMMHSYA DI DMMHSYA DMMHSYA DN [3H]GR65630 DMMHSYA MI TTPC4TU DMMHSYA MN 5-HT 3A receptor (HTR3A) DMMHSYA MT DTT DMMHSYA MA Antagonist DMMHSYA RN Evaluation of the pharmacological profile of ramosetron, a novel therapeutic agent for irritable bowel syndrome. J Pharmacol Sci. 2007 Jul;104(3):263-73. DMMHSYA RU https://pubmed.ncbi.nlm.nih.gov/17652911 DMB9VGW DI DMB9VGW DMB9VGW DN [3H]granisetron DMB9VGW MI TTPC4TU DMB9VGW MN 5-HT 3A receptor (HTR3A) DMB9VGW MT DTT DMB9VGW MA Antagonist DMB9VGW RN Characterization of a human 5-hydroxytryptamine3 receptor type A (h5-HT3R-AS) subunit stably expressed in HEK 293 cells. Br J Pharmacol. 1996 Jul;118(5):1237-45. DMB9VGW RU https://pubmed.ncbi.nlm.nih.gov/8818349 DMB9VGW DI DMB9VGW DMB9VGW DN [3H]granisetron DMB9VGW MI TTR6K75 DMB9VGW MN 5-HT 3B receptor (HTR3B) DMB9VGW MT DTT DMB9VGW MA Antagonist DMB9VGW RN Pharmacological comparison of human homomeric 5-HT3A receptors versus heteromeric 5-HT3A/3B receptors. Neuropharmacology. 2001 Aug;41(2):282-4. DMB9VGW RU https://pubmed.ncbi.nlm.nih.gov/11489465 DMU6A3W DI DMU6A3W DMU6A3W DN [3H]GSK931145 DMU6A3W MI TTHJTF7 DMU6A3W MN Glycine transporter GlyT-1 (SLC6A9) DMU6A3W MT DTT DMU6A3W MA Modulator DMU6A3W RN Pharmacological characterisation of the GlyT-1 glycine transporter using two novel radioligands. Neuropharmacology. 2010 Nov;59(6):558-65. DMU6A3W RU https://pubmed.ncbi.nlm.nih.gov/20691713 DMJT6D3 DI DMJT6D3 DMJT6D3 DN [3H]GW2331 DMJT6D3 MI TTT2SVW DMJT6D3 MN PPAR-gamma messenger RNA (PPARG mRNA) DMJT6D3 MT DTT DMJT6D3 MA Agonist DMJT6D3 RN Fatty acids and eicosanoids regulate gene expression through direct interactions with peroxisome proliferator-activated receptors alpha and gamma. Proc Natl Acad Sci U S A. 1997 Apr 29;94(9):4318-23. DMJT6D3 RU https://pubmed.ncbi.nlm.nih.gov/9113987 DMEO6AH DI DMEO6AH DMEO6AH DN [3H]HEMADO DMEO6AH MI TTK25J1 DMEO6AH MN Adenosine A1 receptor (ADORA1) DMEO6AH MT DTT DMEO6AH MA Agonist DMEO6AH RN [3H]HEMADO--a novel tritiated agonist selective for the human adenosine A3 receptor. Eur J Pharmacol. 2007 Feb 5;556(1-3):14-8. DMEO6AH RU https://pubmed.ncbi.nlm.nih.gov/17126322 DMEO6AH DI DMEO6AH DMEO6AH DN [3H]HEMADO DMEO6AH MI TTNE7KG DMEO6AH MN Adenosine A2b receptor (ADORA2B) DMEO6AH MT DTT DMEO6AH MA Agonist DMEO6AH RN [3H]HEMADO--a novel tritiated agonist selective for the human adenosine A3 receptor. Eur J Pharmacol. 2007 Feb 5;556(1-3):14-8. DMEO6AH RU https://pubmed.ncbi.nlm.nih.gov/17126322 DMEO6AH DI DMEO6AH DMEO6AH DN [3H]HEMADO DMEO6AH MI TTJFY5U DMEO6AH MN Adenosine A3 receptor (ADORA3) DMEO6AH MT DTT DMEO6AH MA Agonist DMEO6AH RN [3H]HEMADO--a novel tritiated agonist selective for the human adenosine A3 receptor. Eur J Pharmacol. 2007 Feb 5;556(1-3):14-8. DMEO6AH RU https://pubmed.ncbi.nlm.nih.gov/17126322 DM190QW DI DM190QW DM190QW DN [3H]hemicholinium-3 DM190QW MI TTRV7W3 DM190QW MN High affinity choline transporter 1 (CHT) DM190QW MT DTT DM190QW MA Modulator DM190QW RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 914). DM190QW RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=914 DMJ5BDQ DI DMJ5BDQ DMJ5BDQ DN [3H]histidine DMJ5BDQ MI TTAYPWS DMJ5BDQ MN Solute carrier family 15 member 3 (SLC15A3) DMJ5BDQ MT DTT DMJ5BDQ MA Modulator DMJ5BDQ RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 986). DMJ5BDQ RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=986 DMJ5BDQ DI DMJ5BDQ DMJ5BDQ DN [3H]histidine DMJ5BDQ MI TTG2XRE DMJ5BDQ MN Solute carrier family 15 member 4 (SLC15A4) DMJ5BDQ MT DTT DMJ5BDQ MA Modulator DMJ5BDQ RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 987). DMJ5BDQ RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=987 DMJ5BDQ DI DMJ5BDQ DMJ5BDQ DN [3H]histidine DMJ5BDQ MI TTC8YPT DMJ5BDQ MN Solute carrier family 38 member 5 (SLC38A5) DMJ5BDQ MT DTT DMJ5BDQ MA Modulator DMJ5BDQ RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1173). DMJ5BDQ RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1173 DM8YUW6 DI DM8YUW6 DM8YUW6 DN [3H]HU-243 DM8YUW6 MI TT6OEDT DM8YUW6 MN Cannabinoid receptor 1 (CB1) DM8YUW6 MT DTT DM8YUW6 MA Agonist DM8YUW6 RN A novel probe for the cannabinoid receptor. J Med Chem. 1992 May 29;35(11):2065-9. DM8YUW6 RU https://pubmed.ncbi.nlm.nih.gov/1317925 DM8YUW6 DI DM8YUW6 DM8YUW6 DN [3H]HU-243 DM8YUW6 MI TTMSFAW DM8YUW6 MN Cannabinoid receptor 2 (CB2) DM8YUW6 MT DTT DM8YUW6 MA Agonist DM8YUW6 RN The peripheral cannabinoid receptor: adenylate cyclase inhibition and G protein coupling. FEBS Lett. 1995 Nov 13;375(1-2):143-7. DM8YUW6 RU https://pubmed.ncbi.nlm.nih.gov/7498464 DMJCI2A DI DMJCI2A DMJCI2A DN [3H]JB-93182 DMJCI2A MI TTVFO0U DMJCI2A MN Gastrin/cholecystokinin type B receptor (CCKBR) DMJCI2A MT DTT DMJCI2A MA Antagonist DMJCI2A RN Characterization of the binding of a novel radioligand to CCKB/gastrin receptors in membranes from rat cerebral cortex. Br J Pharmacol. 1999 Mar;126(6):1504-12. DMJCI2A RU https://pubmed.ncbi.nlm.nih.gov/10217546 DMZT8UD DI DMZT8UD DMZT8UD DN [3H]JNJ 7777120 DMZT8UD MI TTXJ178 DMZT8UD MN Histamine H4 receptor (H4R) DMZT8UD MT DTT DMZT8UD MA Antagonist DMZT8UD RN A potent and selective histamine H4 receptor antagonist with anti-inflammatory properties. J Pharmacol Exp Ther. 2004 Apr;309(1):404-13. DMZT8UD RU https://pubmed.ncbi.nlm.nih.gov/14722321 DMSE56B DI DMSE56B DMSE56B DN [3H]JNJ-40068782 DMSE56B MI TTXJ47W DMSE56B MN Metabotropic glutamate receptor 2 (mGluR2) DMSE56B MT DTT DMSE56B MA Modulator (allosteric modulator) DMSE56B RN Pharmacological characterization of JNJ-40068782, a new potent, selective, and systemically active positive allosteric modulator of the mGlu2 receptor and its radioligand [3H]JNJ-40068782. J Pharmacol Exp Ther. 2013 Sep;346(3):514-27. DMSE56B RU https://pubmed.ncbi.nlm.nih.gov/23766542 DMMK7XU DI DMMK7XU DMMK7XU DN [3H]kainate DMMK7XU MI TTJFY5U DMMK7XU MN Adenosine A3 receptor (ADORA3) DMMK7XU MT DTT DMMK7XU MA Inhibitor DMMK7XU RN 2-n-Butyl-9-methyl-8-[1,2,3]triazol-2-yl-9H-purin-6-ylamine and analogues as A2A adenosine receptor antagonists. Design, synthesis, and pharmacolog... J Med Chem. 2005 Nov 3;48(22):6887-96. DMMK7XU RU https://pubmed.ncbi.nlm.nih.gov/16250647 DMMK7XU DI DMMK7XU DMMK7XU DN [3H]kainate DMMK7XU MI TTAN6JD DMMK7XU MN Glutamate receptor AMPA (GRIA) DMMK7XU MT DTT DMMK7XU MA Inhibitor DMMK7XU RN 1H-cyclopentapyrimidine-2,4(1H,3H)-dione-related ionotropic glutamate receptors ligands. structure-activity relationships and identification of pot... J Med Chem. 2008 Oct 23;51(20):6614-8. DMMK7XU RU https://pubmed.ncbi.nlm.nih.gov/18811139 DMMK7XU DI DMMK7XU DMMK7XU DN [3H]kainate DMMK7XU MI TTVPQTF DMMK7XU MN Glutamate receptor AMPA 1 (GRIA1) DMMK7XU MT DTT DMMK7XU MA Inhibitor DMMK7XU RN 1H-cyclopentapyrimidine-2,4(1H,3H)-dione-related ionotropic glutamate receptors ligands. structure-activity relationships and identification of pot... J Med Chem. 2008 Oct 23;51(20):6614-8. DMMK7XU RU https://pubmed.ncbi.nlm.nih.gov/18811139 DMMK7XU DI DMMK7XU DMMK7XU DN [3H]kainate DMMK7XU MI TT0MYE2 DMMK7XU MN Glutamate receptor ionotropic kainate 1 (GRIK1) DMMK7XU MT DTT DMMK7XU MA Agonist DMMK7XU RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 450). DMMK7XU RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=450 DMMK7XU DI DMMK7XU DMMK7XU DN [3H]kainate DMMK7XU MI TT0K5RG DMMK7XU MN Glutamate receptor ionotropic kainate 2 (GRIK2) DMMK7XU MT DTT DMMK7XU MA Agonist DMMK7XU RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 451). DMMK7XU RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=451 DMMK7XU DI DMMK7XU DMMK7XU DN [3H]kainate DMMK7XU MI TTNP6O2 DMMK7XU MN Glutamate receptor ionotropic kainate 3 (GluK3) DMMK7XU MT DTT DMMK7XU MA Agonist DMMK7XU RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 452). DMMK7XU RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=452 DMMK7XU DI DMMK7XU DMMK7XU DN [3H]kainate DMMK7XU MI TTQV6BO DMMK7XU MN Glutamate receptor ionotropic kainate 4 (GluK4) DMMK7XU MT DTT DMMK7XU MA Agonist DMMK7XU RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 453). DMMK7XU RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=453 DMMK7XU DI DMMK7XU DMMK7XU DN [3H]kainate DMMK7XU MI TTO6LI7 DMMK7XU MN Glutamate receptor ionotropic kainate 5 (GRIK5) DMMK7XU MT DTT DMMK7XU MA Agonist DMMK7XU RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 454). DMMK7XU RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=454 DMUZ9LX DI DMUZ9LX DMUZ9LX DN [3H]L655708 DMUZ9LX MI TTNZPQ1 DMUZ9LX MN GABA(A) receptor alpha-5 (GABRA5) DMUZ9LX MT DTT DMUZ9LX MA Modulator (allosteric modulator) DMUZ9LX RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 408). DMUZ9LX RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=408 DM0YJHS DI DM0YJHS DM0YJHS DN [3H]LSD DM0YJHS MI TT0K1SC DM0YJHS MN 5-HT 2B receptor (HTR2B) DM0YJHS MT DTT DM0YJHS MA Agonist DM0YJHS RN Identification of the binding sites and selectivity of sarpogrelate, a novel 5-HT2 antagonist, to human 5-HT2A, 5-HT2B and 5-HT2C receptor subtypes by molecular modeling. Life Sci. 2003 May 30;73(2):193-207. DM0YJHS RU https://pubmed.ncbi.nlm.nih.gov/12738034 DM0YJHS DI DM0YJHS DM0YJHS DN [3H]LSD DM0YJHS MI TTWJBZ5 DM0YJHS MN 5-HT 2C receptor (HTR2C) DM0YJHS MT DTT DM0YJHS MA Agonist DM0YJHS RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 8). DM0YJHS RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=8 DM0YJHS DI DM0YJHS DM0YJHS DN [3H]LSD DM0YJHS MI TTJS8PY DM0YJHS MN 5-HT 6 receptor (HTR6) DM0YJHS MT DTT DM0YJHS MA Agonist DM0YJHS RN Interactions of the novel antipsychotic aripiprazole (OPC-14597) with dopamine and serotonin receptor subtypes. Neuropsychopharmacology. 1999 Jun;20(6):612-27. DM0YJHS RU https://pubmed.ncbi.nlm.nih.gov/10327430 DM0YJHS DI DM0YJHS DM0YJHS DN [3H]LSD DM0YJHS MI TTO9X1H DM0YJHS MN 5-HT 7 receptor (HTR7) DM0YJHS MT DTT DM0YJHS MA Agonist DM0YJHS RN Human serotonin 5-HT7 receptor: cloning and pharmacological characterisation of two receptor variants. FEBS Lett. 1997 Aug 25;413(3):489-94. DM0YJHS RU https://pubmed.ncbi.nlm.nih.gov/9303561 DMDOJVX DI DMDOJVX DMDOJVX DN [3H]LTB4 DMDOJVX MI TTVJX54 DMDOJVX MN Leukotriene B4 receptor 2 (LTB4R2) DMDOJVX MT DTT DMDOJVX MA Modulator DMDOJVX RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 268). DMDOJVX RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=268 DMD09BO DI DMD09BO DMD09BO DN [3H]LTC4 DMD09BO MI TT0PZR5 DMD09BO MN Leukotriene CysLT2 receptor (CYSLTR2) DMD09BO MT DTT DMD09BO MA Agonist DMD09BO RN The molecular characterization and tissue distribution of the human cysteinyl leukotriene CysLT(2) receptor. Biochem Biophys Res Commun. 2000 Aug 2;274(2):316-22. DMD09BO RU https://pubmed.ncbi.nlm.nih.gov/10913337 DMGX0Y8 DI DMGX0Y8 DMGX0Y8 DN [3H]LY341495 DMGX0Y8 MI TTXJ47W DMGX0Y8 MN Metabotropic glutamate receptor 2 (mGluR2) DMGX0Y8 MT DTT DMGX0Y8 MA Antagonist DMGX0Y8 RN [3H]-LY341495 as a novel antagonist radioligand for group II metabotropic glutamate (mGlu) receptors: characterization of binding to membranes of mGlu receptor subtype expressing cells. Neuropharmacology. 1999 Oct;38(10):1519-29. DMGX0Y8 RU https://pubmed.ncbi.nlm.nih.gov/10530814 DMGX0Y8 DI DMGX0Y8 DMGX0Y8 DN [3H]LY341495 DMGX0Y8 MI TT8A9EF DMGX0Y8 MN Metabotropic glutamate receptor 3 (mGluR3) DMGX0Y8 MT DTT DMGX0Y8 MA Agonist DMGX0Y8 RN Characterization of [(3)H]-LY354740 binding to rat mGlu2 and mGlu3 receptors expressed in CHO cells using semliki forest virus vectors. Neuropharmacology. 2000 Jul 24;39(10):1700-6. DMGX0Y8 RU https://pubmed.ncbi.nlm.nih.gov/10884552 DMGX0Y8 DI DMGX0Y8 DMGX0Y8 DN [3H]LY341495 DMGX0Y8 MI TTWRP2F DMGX0Y8 MN Metabotropic glutamate receptor 6 (mGluR6) DMGX0Y8 MT DTT DMGX0Y8 MA Antagonist DMGX0Y8 RN Binding of [3H](2S,1'S,2'S)-2-(9-xanthylmethyl)-2-(2'-carboxycyclopropyl) glycine ([3H]LY341495) to cell membranes expressing recombinant human group III metabotropic glutamate receptor subtypes. Naunyn Schmiedebergs Arch Pharmacol. 2000 Dec;362(6):546-54. DMGX0Y8 RU https://pubmed.ncbi.nlm.nih.gov/11138847 DMGX0Y8 DI DMGX0Y8 DMGX0Y8 DN [3H]LY341495 DMGX0Y8 MI TT0I76D DMGX0Y8 MN Metabotropic glutamate receptor 7 (mGluR7) DMGX0Y8 MT DTT DMGX0Y8 MA Antagonist DMGX0Y8 RN Binding of [3H](2S,1'S,2'S)-2-(9-xanthylmethyl)-2-(2'-carboxycyclopropyl) glycine ([3H]LY341495) to cell membranes expressing recombinant human group III metabotropic glutamate receptor subtypes. Naunyn Schmiedebergs Arch Pharmacol. 2000 Dec;362(6):546-54. DMGX0Y8 RU https://pubmed.ncbi.nlm.nih.gov/11138847 DMPKGHB DI DMPKGHB DMPKGHB DN [3H]MDL105519 DMPKGHB MI TTLD29N DMPKGHB MN Glutamate receptor ionotropic NMDA 1 (NMDAR1) DMPKGHB MT DTT DMPKGHB MA Antagonist DMPKGHB RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 455). DMPKGHB RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=455 DMPKGHB DI DMPKGHB DMPKGHB DN [3H]MDL105519 DMPKGHB MI TTKJEMQ DMPKGHB MN Glutamate receptor ionotropic NMDA 2A (NMDAR2A) DMPKGHB MT DTT DMPKGHB MA Antagonist DMPKGHB RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 456). DMPKGHB RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=456 DMPKGHB DI DMPKGHB DMPKGHB DN [3H]MDL105519 DMPKGHB MI TTN9D8E DMPKGHB MN Glutamate receptor ionotropic NMDA 2B (NMDAR2B) DMPKGHB MT DTT DMPKGHB MA Antagonist DMPKGHB RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 457). DMPKGHB RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=457 DMPKGHB DI DMPKGHB DMPKGHB DN [3H]MDL105519 DMPKGHB MI TT1M8OW DMPKGHB MN Glutamate receptor ionotropic NMDA 2C (GluN2C) DMPKGHB MT DTT DMPKGHB MA Antagonist DMPKGHB RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 458). DMPKGHB RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=458 DMPKGHB DI DMPKGHB DMPKGHB DN [3H]MDL105519 DMPKGHB MI TT5POTG DMPKGHB MN Glutamate receptor ionotropic NMDA 2D (GluN2D) DMPKGHB MT DTT DMPKGHB MA Antagonist DMPKGHB RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 459). DMPKGHB RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=459 DMEX6GT DI DMEX6GT DMEX6GT DN [3H]meclinertant DMEX6GT MI TTTUMEP DMEX6GT MN Neurotensin receptor type 1 (NTSR1) DMEX6GT MT DTT DMEX6GT MA Antagonist DMEX6GT RN [3H]SR 48692, the first nonpeptide neurotensin antagonist radioligand: characterization of binding properties and evidence for distinct agonist and antagonist binding domains on the rat neurotensin receptor. Mol Pharmacol. 1995 May;47(5):1050-6. DMEX6GT RU https://pubmed.ncbi.nlm.nih.gov/7746272 DM8K6VF DI DM8K6VF DM8K6VF DN [3H]mesulergine DM8K6VF MI TT0K1SC DM8K6VF MN 5-HT 2B receptor (HTR2B) DM8K6VF MT DTT DM8K6VF MA Antagonist DM8K6VF RN Pharmacological characterisation of the agonist radioligand binding site of 5-HT(2A), 5-HT(2B) and 5-HT(2C) receptors. Naunyn Schmiedebergs Arch Pharmacol. 2004 Aug;370(2):114-23. DM8K6VF RU https://pubmed.ncbi.nlm.nih.gov/15322733 DM8K6VF DI DM8K6VF DM8K6VF DN [3H]mesulergine DM8K6VF MI TTWJBZ5 DM8K6VF MN 5-HT 2C receptor (HTR2C) DM8K6VF MT DTT DM8K6VF MA Antagonist DM8K6VF RN High-affinity agonist binding correlates with efficacy (intrinsic activity) at the human serotonin 5-HT2A and 5-HT2C receptors: evidence favoring the ternary complex and two-state models of agonist action. J Neurochem. 1999 May;72(5):2127-34. DM8K6VF RU https://pubmed.ncbi.nlm.nih.gov/10217294 DMONI13 DI DMONI13 DMONI13 DN [3H]methoxymethyl-MTEP DMONI13 MI TTHS256 DMONI13 MN Metabotropic glutamate receptor 5 (mGluR5) DMONI13 MT DTT DMONI13 MA Modulator (allosteric modulator) DMONI13 RN [3H]Methoxymethyl-3-[(2-methyl-1,3-thiazol-4-yl)ethynyl]pyridine binding to metabotropic glutamate receptor subtype 5 in rodent brain: in vitro and in vivo characterization. J Pharmacol Exp Ther. 2002 Dec;303(3):1044-51. DMONI13 RU https://pubmed.ncbi.nlm.nih.gov/12438526 DMZ2R1O DI DMZ2R1O DMZ2R1O DN [3H]methoxy-PEPy DMZ2R1O MI TTHS256 DMZ2R1O MN Metabotropic glutamate receptor 5 (mGluR5) DMZ2R1O MT DTT DMZ2R1O MA Modulator (allosteric modulator) DMZ2R1O RN [3H]-methoxymethyl-MTEP and [3H]-methoxy-PEPy: potent and selective radioligands for the metabotropic glutamate subtype 5 (mGlu5) receptor. Bioorg Med Chem Lett. 2003 Feb 10;13(3):351-4. DMZ2R1O RU https://pubmed.ncbi.nlm.nih.gov/12565928 DMYWGCS DI DMYWGCS DMYWGCS DN [3H]methyllycaconitine DMYWGCS MI TTJ49OM DMYWGCS MN Neuronal acetylcholine receptor alpha-10 (CHRNA10) DMYWGCS MT DTT DMYWGCS MA Antagonist DMYWGCS RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 470). DMYWGCS RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=470 DMYWGCS DI DMYWGCS DMYWGCS DN [3H]methyllycaconitine DMYWGCS MI TTLA931 DMYWGCS MN Neuronal acetylcholine receptor alpha-7 (CHRNA7) DMYWGCS MT DTT DMYWGCS MA Antagonist DMYWGCS RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 468). DMYWGCS RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=468 DMYWGCS DI DMYWGCS DMYWGCS DN [3H]methyllycaconitine DMYWGCS MI TTQACP9 DMYWGCS MN Neuronal acetylcholine receptor alpha-9 (CHRNA9) DMYWGCS MT DTT DMYWGCS MA Antagonist DMYWGCS RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 469). DMYWGCS RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=469 DMTSGOW DI DMTSGOW DMTSGOW DN [3H]methyltrienolone DMTSGOW MI TTS64P2 DMTSGOW MN Androgen receptor (AR) DMTSGOW MT DTT DMTSGOW MA Inhibitor DMTSGOW RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMTSGOW RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMTSGOW DI DMTSGOW DMTSGOW DN [3H]methyltrienolone DMTSGOW MI TTKPW01 DMTSGOW MN Androgen receptor messenger RNA (AR mRNA) DMTSGOW MT DTT DMTSGOW MA Agonist DMTSGOW RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 628). DMTSGOW RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=628 DMTSGOW DI DMTSGOW DMTSGOW DN [3H]methyltrienolone DMTSGOW MI TTUV8G9 DMTSGOW MN Progesterone receptor (PGR) DMTSGOW MT DTT DMTSGOW MA Inhibitor DMTSGOW RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMTSGOW RU https://pubmed.ncbi.nlm.nih.gov/17139284 DM6HDKQ DI DM6HDKQ DM6HDKQ DN [3H]mibolerone DM6HDKQ MI TTS64P2 DM6HDKQ MN Androgen receptor (AR) DM6HDKQ MT DTT DM6HDKQ MA Inhibitor DM6HDKQ RN Design, synthesis, and pharmacological characterization of 4-[4, 4-dimethyl-3-(4-hydroxybutyl)-5-oxo-2-thioxo-1-imidazolidinyl]- 2-iodobenzonitrile... J Med Chem. 2000 Aug 24;43(17):3344-7. DM6HDKQ RU https://pubmed.ncbi.nlm.nih.gov/10966753 DM6HDKQ DI DM6HDKQ DM6HDKQ DN [3H]mibolerone DM6HDKQ MI TTKPW01 DM6HDKQ MN Androgen receptor messenger RNA (AR mRNA) DM6HDKQ MT DTT DM6HDKQ MA Agonist DM6HDKQ RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 628). DM6HDKQ RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=628 DMO89N0 DI DMO89N0 DMO89N0 DN [3H]MK-912 DMO89N0 MI TTWM4TY DMO89N0 MN Adrenergic receptor alpha-2B (ADRA2B) DMO89N0 MT DTT DMO89N0 MA Antagonist DMO89N0 RN The novel alpha-2 adrenergic radioligand [3H]-MK912 is alpha-2C selective among human alpha-2A, alpha-2B and alpha-2C adrenoceptors. J Pharmacol Exp Ther. 1994 Dec;271(3):1558-65. DMO89N0 RU https://pubmed.ncbi.nlm.nih.gov/7996470 DMO89N0 DI DMO89N0 DMO89N0 DN [3H]MK-912 DMO89N0 MI TT2NUT5 DMO89N0 MN Adrenergic receptor alpha-2C (ADRA2C) DMO89N0 MT DTT DMO89N0 MA Antagonist DMO89N0 RN The novel alpha-2 adrenergic radioligand [3H]-MK912 is alpha-2C selective among human alpha-2A, alpha-2B and alpha-2C adrenoceptors. J Pharmacol Exp Ther. 1994 Dec;271(3):1558-65. DMO89N0 RU https://pubmed.ncbi.nlm.nih.gov/7996470 DM0THB9 DI DM0THB9 DM0THB9 DN [3H]N5-methylfolate DM0THB9 MI TTY8Z2E DM0THB9 MN Proton-coupled folate transporter (SLC46A1) DM0THB9 MT DTT DM0THB9 MA Modulator DM0THB9 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1213). DM0THB9 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1213 DMQW3A9 DI DMQW3A9 DMQW3A9 DN [3H]naltrindole DMQW3A9 MI TT27RFC DMQW3A9 MN Opioid receptor delta (OPRD1) DMQW3A9 MT DTT DMQW3A9 MA Antagonist DMQW3A9 RN Characterization of [3H]naltrindole binding to delta opioid receptors in rat brain. Life Sci. 1992;50(16):PL119-24. DMQW3A9 RU https://pubmed.ncbi.nlm.nih.gov/1313133 DMAO9SH DI DMAO9SH DMAO9SH DN [3H]NECA DMAO9SH MI TTK25J1 DMAO9SH MN Adenosine A1 receptor (ADORA1) DMAO9SH MT DTT DMAO9SH MA Inhibitor DMAO9SH RN Adenosine receptor agonists: synthesis and biological evaluation of 1-deaza analogues of adenosine derivatives. J Med Chem. 1988 Jun;31(6):1179-83. DMAO9SH RU https://pubmed.ncbi.nlm.nih.gov/3373486 DMAO9SH DI DMAO9SH DMAO9SH DN [3H]NECA DMAO9SH MI TTM2AOE DMAO9SH MN Adenosine A2a receptor (ADORA2A) DMAO9SH MT DTT DMAO9SH MA Inhibitor DMAO9SH RN Adenosine receptor agonists: synthesis and biological evaluation of 1-deaza analogues of adenosine derivatives. J Med Chem. 1988 Jun;31(6):1179-83. DMAO9SH RU https://pubmed.ncbi.nlm.nih.gov/3373486 DMAO9SH DI DMAO9SH DMAO9SH DN [3H]NECA DMAO9SH MI TTNE7KG DMAO9SH MN Adenosine A2b receptor (ADORA2B) DMAO9SH MT DTT DMAO9SH MA Agonist DMAO9SH RN Comparative pharmacology of human adenosine receptor subtypes - characterization of stably transfected receptors in CHO cells. Naunyn Schmiedebergs Arch Pharmacol. 1998 Jan;357(1):1-9. DMAO9SH RU https://pubmed.ncbi.nlm.nih.gov/9459566 DMAO9SH DI DMAO9SH DMAO9SH DN [3H]NECA DMAO9SH MI TTJFY5U DMAO9SH MN Adenosine A3 receptor (ADORA3) DMAO9SH MT DTT DMAO9SH MA Agonist DMAO9SH RN Inhibition of human mast cell activation with the novel selective adenosine A(2B) receptor antagonist 3-isobutyl-8-pyrrolidinoxanthine (IPDX)(2). Biochem Pharmacol. 2001 Nov 1;62(9):1163-73. DMAO9SH RU https://pubmed.ncbi.nlm.nih.gov/11705449 DM0163O DI DM0163O DM0163O DN [3H]nelivaptan DM0163O MI TTL9MHW DM0163O MN Vasopressin V1b receptor (V1BR) DM0163O MT DTT DM0163O MA Antagonist DM0163O RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 367). DM0163O RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=367 DM6PO49 DI DM6PO49 DM6PO49 DN [3H]NFPS DM6PO49 MI TTHJTF7 DM6PO49 MN Glycine transporter GlyT-1 (SLC6A9) DM6PO49 MT DTT DM6PO49 MA Modulator DM6PO49 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 935). DM6PO49 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=935 DM9E2YI DI DM9E2YI DM9E2YI DN [3H]nicotine DM9E2YI MI TT5KPZR DM9E2YI MN Neuronal acetylcholine receptor beta-2 (CHRNB2) DM9E2YI MT DTT DM9E2YI MA Agonist DM9E2YI RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 465). DM9E2YI RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=465 DMS3WNG DI DMS3WNG DMS3WNG DN [3H]nisoxetine DMS3WNG MI TTAWNKZ DMS3WNG MN Norepinephrine transporter (NET) DMS3WNG MT DTT DMS3WNG MA Inhibitor DMS3WNG RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 926). DMS3WNG RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=926 DM5TDFQ DI DM5TDFQ DM5TDFQ DN [3H]nitrobenzylmercaptopurine ribonucleoside DM5TDFQ MI TTLXAKE DM5TDFQ MN Solute carrier family 29 member 1 (SLC29A1) DM5TDFQ MT DTT DM5TDFQ MA Modulator DM5TDFQ RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1117). DM5TDFQ RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1117 DMG1TIV DI DMG1TIV DMG1TIV DN [3H]NLX-112 DMG1TIV MI TTSQIFT DMG1TIV MN 5-HT 1A receptor (HTR1A) DMG1TIV MT DTT DMG1TIV MA Agonist DMG1TIV RN [(3)H]-F13640, a novel, selective and high-efficacy serotonin 5-HT(1A) receptor agonist radioligand. Naunyn Schmiedebergs Arch Pharmacol. 2010 Oct;382(4):321-30. DMG1TIV RU https://pubmed.ncbi.nlm.nih.gov/20799027 DM5176Y DI DM5176Y DM5176Y DN [3H]N-methylspiperone DM5176Y MI TTJQOD7 DM5176Y MN 5-HT 2A receptor (HTR2A) DM5176Y MT DTT DM5176Y MA Antagonist DM5176Y RN Differential modes of agonist binding to 5-hydroxytryptamine(2A) serotonin receptors revealed by mutation and molecular modeling of conserved residues in transmembrane region 5. Mol Pharmacol. 2000 Nov;58(5):877-86. DM5176Y RU https://pubmed.ncbi.nlm.nih.gov/11040033 DM5176Y DI DM5176Y DM5176Y DN [3H]N-methylspiperone DM5176Y MI TTEX248 DM5176Y MN Dopamine D2 receptor (D2R) DM5176Y MT DTT DM5176Y MA Antagonist DM5176Y RN Nonconserved residues in the second transmembrane-spanning domain of the D(4) dopamine receptor are molecular determinants of D(4)-selective pharmacology. Mol Pharmacol. 2000 Jan;57(1):144-52. DM5176Y RU https://pubmed.ncbi.nlm.nih.gov/10617689 DM5176Y DI DM5176Y DM5176Y DN [3H]N-methylspiperone DM5176Y MI TTE0A2F DM5176Y MN Dopamine D4 receptor (D4R) DM5176Y MT DTT DM5176Y MA Antagonist DM5176Y RN Nonconserved residues in the second transmembrane-spanning domain of the D(4) dopamine receptor are molecular determinants of D(4)-selective pharmacology. Mol Pharmacol. 2000 Jan;57(1):144-52. DM5176Y RU https://pubmed.ncbi.nlm.nih.gov/10617689 DMX4RJ8 DI DMX4RJ8 DMX4RJ8 DN [3H]N-methyl-SSR504734 DMX4RJ8 MI TTHJTF7 DMX4RJ8 MN Glycine transporter GlyT-1 (SLC6A9) DMX4RJ8 MT DTT DMX4RJ8 MA Modulator DMX4RJ8 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 935). DMX4RJ8 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=935 DM4BY5J DI DM4BY5J DM4BY5J DN [3H]OSIP339391 DM4BY5J MI TTK25J1 DM4BY5J MN Adenosine A1 receptor (ADORA1) DM4BY5J MT DTT DM4BY5J MA Inhibitor DM4BY5J RN Insights into binding modes of adenosine A(2B) antagonists with ligand-based and receptor-based methods. Eur J Med Chem. 2010 Aug;45(8):3459-71. DM4BY5J RU https://pubmed.ncbi.nlm.nih.gov/20537438 DM4BY5J DI DM4BY5J DM4BY5J DN [3H]OSIP339391 DM4BY5J MI TTM2AOE DM4BY5J MN Adenosine A2a receptor (ADORA2A) DM4BY5J MT DTT DM4BY5J MA Inhibitor DM4BY5J RN Insights into binding modes of adenosine A(2B) antagonists with ligand-based and receptor-based methods. Eur J Med Chem. 2010 Aug;45(8):3459-71. DM4BY5J RU https://pubmed.ncbi.nlm.nih.gov/20537438 DM4BY5J DI DM4BY5J DM4BY5J DN [3H]OSIP339391 DM4BY5J MI TTNE7KG DM4BY5J MN Adenosine A2b receptor (ADORA2B) DM4BY5J MT DTT DM4BY5J MA Antagonist DM4BY5J RN [3H]OSIP339391, a selective, novel, and high affinity antagonist radioligand for adenosine A2B receptors. Biochem Pharmacol. 2004 Jul 15;68(2):305-12. DM4BY5J RU https://pubmed.ncbi.nlm.nih.gov/15194002 DM4BY5J DI DM4BY5J DM4BY5J DN [3H]OSIP339391 DM4BY5J MI TTJFY5U DM4BY5J MN Adenosine A3 receptor (ADORA3) DM4BY5J MT DTT DM4BY5J MA Inhibitor DM4BY5J RN Insights into binding modes of adenosine A(2B) antagonists with ligand-based and receptor-based methods. Eur J Med Chem. 2010 Aug;45(8):3459-71. DM4BY5J RU https://pubmed.ncbi.nlm.nih.gov/20537438 DM5L7D3 DI DM5L7D3 DM5L7D3 DN [3H]oxotremorine-M DM5L7D3 MI TTOXS3C DM5L7D3 MN Muscarinic acetylcholine receptor (CHRM) DM5L7D3 MT DTT DM5L7D3 MA Agonist DM5L7D3 RN Positive cooperativity of acetylcholine and other agonists with allosteric ligands on muscarinic acetylcholine receptors. Mol Pharmacol. 1997 Jul;52(1):172-9. DM5L7D3 RU https://pubmed.ncbi.nlm.nih.gov/9224827 DM5L7D3 DI DM5L7D3 DM5L7D3 DN [3H]oxotremorine-M DM5L7D3 MI TTQ13Z5 DM5L7D3 MN Muscarinic acetylcholine receptor M3 (CHRM3) DM5L7D3 MT DTT DM5L7D3 MA Agonist DM5L7D3 RN Positive cooperativity of acetylcholine and other agonists with allosteric ligands on muscarinic acetylcholine receptors. Mol Pharmacol. 1997 Jul;52(1):172-9. DM5L7D3 RU https://pubmed.ncbi.nlm.nih.gov/9224827 DMK46C7 DI DMK46C7 DMK46C7 DN [3H]PBC-264 DMK46C7 MI TTVFO0U DMK46C7 MN Gastrin/cholecystokinin type B receptor (CCKBR) DMK46C7 MT DTT DMK46C7 MA Agonist DMK46C7 RN [3H]pBC 264, a suitable probe for studying cholecystokinin-B receptors: binding characteristics in rodent brains and comparison with [3H]SNF 8702. Mol Pharmacol. 1992 Jun;41(6):1089-95. DMK46C7 RU https://pubmed.ncbi.nlm.nih.gov/1614411 DMWAT5S DI DMWAT5S DMWAT5S DN [3H]PD140376 DMWAT5S MI TTVFO0U DMWAT5S MN Gastrin/cholecystokinin type B receptor (CCKBR) DMWAT5S MT DTT DMWAT5S MA Antagonist DMWAT5S RN [3H]PD 140376: a novel and highly selective antagonist radioligand for the cholecystokininB/gastrin receptor in guinea pig cerebral cortex and gastric mucosa. Mol Pharmacol. 1993 Apr;43(4):595-602. DMWAT5S RU https://pubmed.ncbi.nlm.nih.gov/8474432 DMF4TWE DI DMF4TWE DMF4TWE DN [3H]pentazocine DMF4TWE MI TT5TPI6 DMF4TWE MN Opioid receptor sigma 1 (OPRS1) DMF4TWE MT DTT DMF4TWE MA Agonist DMF4TWE RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2552). DMF4TWE RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2552 DMPE1B2 DI DMPE1B2 DMPE1B2 DN [3H]PGF2alpha DMPE1B2 MI TTT2ZAR DMPE1B2 MN Prostaglandin F2-alpha receptor (PTGFR) DMPE1B2 MT DTT DMPE1B2 MA Agonist DMPE1B2 RN Cloning and expression of a cDNA for the human prostanoid FP receptor. J Biol Chem. 1994 Jan 28;269(4):2632-6. DMPE1B2 RU https://pubmed.ncbi.nlm.nih.gov/8300593 DMAMD5H DI DMAMD5H DMAMD5H DN [3H]pirenzepine DMAMD5H MI TTOXS3C DMAMD5H MN Muscarinic acetylcholine receptor (CHRM) DMAMD5H MT DTT DMAMD5H MA Antagonist DMAMD5H RN [3H]Pirenzepine identifies putative M1 muscarinic receptors in human stellate ganglia. Brain Res. 1984 Jan 2;290(1):179-82. DMAMD5H RU https://pubmed.ncbi.nlm.nih.gov/6546354 DM2LA9X DI DM2LA9X DM2LA9X DN [3H]p-MPPF DM2LA9X MI TTSQIFT DM2LA9X MN 5-HT 1A receptor (HTR1A) DM2LA9X MT DTT DM2LA9X MA Antagonist DM2LA9X RN Ligand binding characteristics of the human serotonin1A receptor heterologously expressed in CHO cells. Biosci Rep. 2004 Apr;24(2):101-15. DM2LA9X RU https://pubmed.ncbi.nlm.nih.gov/15628665 DMP98AQ DI DMP98AQ DMP98AQ DN [3H]PSB-0413 DMP98AQ MI TTZ1DT0 DMP98AQ MN P2Y purinoceptor 12 (P2RY12) DMP98AQ MT DTT DMP98AQ MA Antagonist DMP98AQ RN Synthesis and preliminary evaluation of [3H]PSB-0413, a selective antagonist radioligand for platelet P2Y12 receptors. Bioorg Med Chem Lett. 2005 Dec 15;15(24):5450-2. DMP98AQ RU https://pubmed.ncbi.nlm.nih.gov/16213725 DMFDCJK DI DMFDCJK DMFDCJK DN [3H]PSB-11 DMFDCJK MI TTJFY5U DMFDCJK MN Adenosine A3 receptor (ADORA3) DMFDCJK MT DTT DMFDCJK MA Antagonist DMFDCJK RN [(3)H]8-Ethyl-4-methyl-2-phenyl-(8R)-4,5,7,8-tetrahydro-1H-imidazo[2,1-i]-purin-5-one ([(3)H]PSB-11), a novel high-affinity antagonist radioligand for human A(3) adenosine receptors. Bioorg Med Chem Lett. 2002 Feb 11;12(3):501-3. DMFDCJK RU https://pubmed.ncbi.nlm.nih.gov/11814828 DMC1WHR DI DMC1WHR DMC1WHR DN [3H]QNB DMC1WHR MI TTOXS3C DMC1WHR MN Muscarinic acetylcholine receptor (CHRM) DMC1WHR MT DTT DMC1WHR MA Antagonist DMC1WHR RN Interaction of anandamide with the M(1) and M(4) muscarinic acetylcholine receptors. Brain Res. 2001 Oct 5;915(1):70-8. DMC1WHR RU https://pubmed.ncbi.nlm.nih.gov/11578621 DMC1WHR DI DMC1WHR DMC1WHR DN [3H]QNB DMC1WHR MI TTQ13Z5 DMC1WHR MN Muscarinic acetylcholine receptor M3 (CHRM3) DMC1WHR MT DTT DMC1WHR MA Antagonist DMC1WHR RN Distinct primary structures, ligand-binding properties and tissue-specific expression of four human muscarinic acetylcholine receptors. EMBO J. 1987 Dec 20;6(13):3923-9. DMC1WHR RU https://pubmed.ncbi.nlm.nih.gov/3443095 DMDQBTX DI DMDQBTX DMDQBTX DN [3H]quisqualate DMDQBTX MI TT9G4N0 DMDQBTX MN Glutamate carboxypeptidase II (GCPII) DMDQBTX MT DTT DMDQBTX MA Inhibitor DMDQBTX RN Structural insight into the pharmacophore pocket of human glutamate carboxypeptidase II. J Med Chem. 2007 Jul 12;50(14):3267-73. DMDQBTX RU https://pubmed.ncbi.nlm.nih.gov/17567119 DMDQBTX DI DMDQBTX DMDQBTX DN [3H]quisqualate DMDQBTX MI TT0MYE2 DMDQBTX MN Glutamate receptor ionotropic kainate 1 (GRIK1) DMDQBTX MT DTT DMDQBTX MA Inhibitor DMDQBTX RN Chemo-enzymatic synthesis of a series of 2,4-syn-functionalized (S)-glutamate analogues: new insight into the structure-activity relation of ionotr... J Med Chem. 2008 Jul 24;51(14):4093-103. DMDQBTX RU https://pubmed.ncbi.nlm.nih.gov/18578478 DMDQBTX DI DMDQBTX DMDQBTX DN [3H]quisqualate DMDQBTX MI TTVBPDM DMDQBTX MN Metabotropic glutamate receptor 1 (mGluR1) DMDQBTX MT DTT DMDQBTX MA Agonist DMDQBTX RN Mutational analysis and molecular modeling of the allosteric binding site of a novel, selective, noncompetitive antagonist of the metabotropic glut... J Biol Chem. 2003 Mar 7;278(10):8340-7. DMDQBTX RU https://pubmed.ncbi.nlm.nih.gov/12509432 DMDQBTX DI DMDQBTX DMDQBTX DN [3H]quisqualate DMDQBTX MI TTXJ47W DMDQBTX MN Metabotropic glutamate receptor 2 (mGluR2) DMDQBTX MT DTT DMDQBTX MA Inhibitor DMDQBTX RN Excitatory amino acid receptor ligands: resolution, absolute stereochemistry, and enantiopharmacology of 2-amino-3-(4-butyl-3-hydroxyisoxazol-5-yl)... J Med Chem. 1998 Mar 12;41(6):930-9. DMDQBTX RU https://pubmed.ncbi.nlm.nih.gov/9526567 DMDQBTX DI DMDQBTX DMDQBTX DN [3H]quisqualate DMDQBTX MI TT8A9EF DMDQBTX MN Metabotropic glutamate receptor 3 (mGluR3) DMDQBTX MT DTT DMDQBTX MA Inhibitor DMDQBTX RN Excitatory amino acid receptor ligands: resolution, absolute stereochemistry, and enantiopharmacology of 2-amino-3-(4-butyl-3-hydroxyisoxazol-5-yl)... J Med Chem. 1998 Mar 12;41(6):930-9. DMDQBTX RU https://pubmed.ncbi.nlm.nih.gov/9526567 DMDQBTX DI DMDQBTX DMDQBTX DN [3H]quisqualate DMDQBTX MI TTHS256 DMDQBTX MN Metabotropic glutamate receptor 5 (mGluR5) DMDQBTX MT DTT DMDQBTX MA Inhibitor DMDQBTX RN Excitatory amino acid receptor ligands: resolution, absolute stereochemistry, and enantiopharmacology of 2-amino-3-(4-butyl-3-hydroxyisoxazol-5-yl)... J Med Chem. 1998 Mar 12;41(6):930-9. DMDQBTX RU https://pubmed.ncbi.nlm.nih.gov/9526567 DMDQBTX DI DMDQBTX DMDQBTX DN [3H]quisqualate DMDQBTX MI TT0I76D DMDQBTX MN Metabotropic glutamate receptor 7 (mGluR7) DMDQBTX MT DTT DMDQBTX MA Inhibitor DMDQBTX RN Excitatory amino acid receptor ligands: resolution, absolute stereochemistry, and enantiopharmacology of 2-amino-3-(4-butyl-3-hydroxyisoxazol-5-yl)... J Med Chem. 1998 Mar 12;41(6):930-9. DMDQBTX RU https://pubmed.ncbi.nlm.nih.gov/9526567 DMDQBTX DI DMDQBTX DMDQBTX DN [3H]quisqualate DMDQBTX MI TT0IFKL DMDQBTX MN Metabotropic glutamate receptor 8 (mGluR8) DMDQBTX MT DTT DMDQBTX MA Inhibitor DMDQBTX RN Excitatory amino acid receptor ligands: resolution, absolute stereochemistry, and enantiopharmacology of 2-amino-3-(4-butyl-3-hydroxyisoxazol-5-yl)... J Med Chem. 1998 Mar 12;41(6):930-9. DMDQBTX RU https://pubmed.ncbi.nlm.nih.gov/9526567 DM21B46 DI DM21B46 DM21B46 DN [3H]ramosetron DM21B46 MI TTPC4TU DM21B46 MN 5-HT 3A receptor (HTR3A) DM21B46 MT DTT DM21B46 MA Antagonist DM21B46 RN Molecular cloning of human 5-hydroxytryptamine3 receptor: heterogeneity in distribution and function among species. Mol Pharmacol. 1995 Sep;48(3):407-16. DM21B46 RU https://pubmed.ncbi.nlm.nih.gov/7565620 DMBQZ2H DI DMBQZ2H DMBQZ2H DN [3H]rauwolscine DMBQZ2H MI TT0K1SC DMBQZ2H MN 5-HT 2B receptor (HTR2B) DMBQZ2H MT DTT DMBQZ2H MA Antagonist DMBQZ2H RN [3H]Rauwolscine: an antagonist radioligand for the cloned human 5-hydroxytryptamine2b (5-HT2B) receptor. Naunyn Schmiedebergs Arch Pharmacol. 1998 Jan;357(1):17-24. DMBQZ2H RU https://pubmed.ncbi.nlm.nih.gov/9459568 DMBQZ2H DI DMBQZ2H DMBQZ2H DN [3H]rauwolscine DMBQZ2H MI TTQ8AFT DMBQZ2H MN Adrenergic receptor Alpha-2 (ADRA2) DMBQZ2H MT DTT DMBQZ2H MA Antagonist DMBQZ2H RN Characterization of alpha-adrenoceptor subtypes in smooth muscle of equine ileum. Am J Vet Res. 2001 Sep;62(9):1370-4. DMBQZ2H RU https://pubmed.ncbi.nlm.nih.gov/11560262 DMBQZ2H DI DMBQZ2H DMBQZ2H DN [3H]rauwolscine DMBQZ2H MI TTWM4TY DMBQZ2H MN Adrenergic receptor alpha-2B (ADRA2B) DMBQZ2H MT DTT DMBQZ2H MA Antagonist DMBQZ2H RN Pharmacological characteristics of alpha 2-adrenergic receptors: comparison of pharmacologically defined subtypes with subtypes identified by molecular cloning. Mol Pharmacol. 1992 Jul;42(1):1-5. DMBQZ2H RU https://pubmed.ncbi.nlm.nih.gov/1353247 DMBQZ2H DI DMBQZ2H DMBQZ2H DN [3H]rauwolscine DMBQZ2H MI TT2NUT5 DMBQZ2H MN Adrenergic receptor alpha-2C (ADRA2C) DMBQZ2H MT DTT DMBQZ2H MA Antagonist DMBQZ2H RN Pharmacological characteristics of alpha 2-adrenergic receptors: comparison of pharmacologically defined subtypes with subtypes identified by molecular cloning. Mol Pharmacol. 1992 Jul;42(1):1-5. DMBQZ2H RU https://pubmed.ncbi.nlm.nih.gov/1353247 DMFT0HU DI DMFT0HU DMFT0HU DN [3H]resolvin D1 DMFT0HU MI TTOJ1NF DMFT0HU MN FMLP-related receptor I (FPR2) DMFT0HU MT DTT DMFT0HU MA Agonist DMFT0HU RN Resolvin D1 binds human phagocytes with evidence for proresolving receptors. Proc Natl Acad Sci U S A. 2010 Jan 26;107(4):1660-5. DMFT0HU RU https://pubmed.ncbi.nlm.nih.gov/20080636 DMFT0HU DI DMFT0HU DMFT0HU DN [3H]resolvin D1 DMFT0HU MI TT7OCUB DMFT0HU MN G-protein coupled receptor 32 (GPR32) DMFT0HU MT DTT DMFT0HU MA Agonist DMFT0HU RN Resolvin D1 binds human phagocytes with evidence for proresolving receptors. Proc Natl Acad Sci U S A. 2010 Jan 26;107(4):1660-5. DMFT0HU RU https://pubmed.ncbi.nlm.nih.gov/20080636 DMFT0HU DI DMFT0HU DMFT0HU DN [3H]resolvin D1 DMFT0HU MI TTELV3W DMFT0HU MN Transformation-sensitive protein p120 (TRPA1) DMFT0HU MT DTT DMFT0HU MA Inhibitor (gating inhibitor) DMFT0HU RN Resolvin D1 attenuates activation of sensory transient receptor potential channels leading to multiple anti-nociception. Br J Pharmacol. 2010 Oct;161(3):707-20. DMFT0HU RU https://pubmed.ncbi.nlm.nih.gov/20880407 DMAMK3P DI DMAMK3P DMAMK3P DN [3H]resolvin E1 DMAMK3P MI TT4UGZL DMAMK3P MN Chemerin receptor (CMKLR1) DMAMK3P MT DTT DMAMK3P MA Agonist DMAMK3P RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 79). DMAMK3P RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=79 DMAMK3P DI DMAMK3P DMAMK3P DN [3H]resolvin E1 DMAMK3P MI TTHS256 DMAMK3P MN Metabotropic glutamate receptor 5 (mGluR5) DMAMK3P MT DTT DMAMK3P MA Modulator (allosteric modulator) DMAMK3P RN Rational design of 7-arylquinolines as non-competitive metabotropic glutamate receptor subtype 5 antagonists. Bioorg Med Chem Lett. 2007 Aug 15;17(16):4415-8. DMAMK3P RU https://pubmed.ncbi.nlm.nih.gov/17590335 DM5XSMN DI DM5XSMN DM5XSMN DN [3H]Ro 63-0563 DM5XSMN MI TTJS8PY DM5XSMN MN 5-HT 6 receptor (HTR6) DM5XSMN MT DTT DM5XSMN MA Antagonist DM5XSMN RN The 5-hydroxytryptamine6 receptor-selective radioligand [3H]Ro 63-0563 labels 5-hydroxytryptamine receptor binding sites in rat and porcine striatum. Mol Pharmacol. 1998 Sep;54(3):577-83. DM5XSMN RU https://pubmed.ncbi.nlm.nih.gov/9730917 DMMBWKL DI DMMBWKL DMMBWKL DN [3H]Ro154513 DMMBWKL MI TT1MPAY DMMBWKL MN GABA(A) receptor alpha-1 (GABRA1) DMMBWKL MT DTT DMMBWKL MA Inhibitor DMMBWKL RN Synthesis and evaluation of imidazo[1,5-a][1,4]benzodiazepine esters with high affinities and selectivities at "diazepam-insensitive" benzodiazepin... J Med Chem. 1993 Apr 16;36(8):1001-6. DMMBWKL RU https://pubmed.ncbi.nlm.nih.gov/8386769 DMMBWKL DI DMMBWKL DMMBWKL DN [3H]Ro154513 DMMBWKL MI TTBMV1G DMMBWKL MN GABA(A) receptor alpha-2 (GABRA2) DMMBWKL MT DTT DMMBWKL MA Inhibitor DMMBWKL RN Synthesis and pharmacological properties of novel 8-substituted imidazobenzodiazepines: high-affinity, selective probes for alpha 5-containing GABA... J Med Chem. 1996 Apr 26;39(9):1928-34. DMMBWKL RU https://pubmed.ncbi.nlm.nih.gov/8627617 DMMBWKL DI DMMBWKL DMMBWKL DN [3H]Ro154513 DMMBWKL MI TT37EDJ DMMBWKL MN GABA(A) receptor alpha-3 (GABRA3) DMMBWKL MT DTT DMMBWKL MA Inhibitor DMMBWKL RN Synthesis and pharmacological properties of novel 8-substituted imidazobenzodiazepines: high-affinity, selective probes for alpha 5-containing GABA... J Med Chem. 1996 Apr 26;39(9):1928-34. DMMBWKL RU https://pubmed.ncbi.nlm.nih.gov/8627617 DMMBWKL DI DMMBWKL DMMBWKL DN [3H]Ro154513 DMMBWKL MI TTNZPQ1 DMMBWKL MN GABA(A) receptor alpha-5 (GABRA5) DMMBWKL MT DTT DMMBWKL MA Inhibitor DMMBWKL RN Synthesis and pharmacological properties of novel 8-substituted imidazobenzodiazepines: high-affinity, selective probes for alpha 5-containing GABA... J Med Chem. 1996 Apr 26;39(9):1928-34. DMMBWKL RU https://pubmed.ncbi.nlm.nih.gov/8627617 DMMBWKL DI DMMBWKL DMMBWKL DN [3H]Ro154513 DMMBWKL MI TTZA1NY DMMBWKL MN GABA(A) receptor beta-2 (GABRB2) DMMBWKL MT DTT DMMBWKL MA Inhibitor DMMBWKL RN Synthesis and evaluation of imidazo[1,5-a][1,4]benzodiazepine esters with high affinities and selectivities at "diazepam-insensitive" benzodiazepin... J Med Chem. 1993 Apr 16;36(8):1001-6. DMMBWKL RU https://pubmed.ncbi.nlm.nih.gov/8386769 DMMBWKL DI DMMBWKL DMMBWKL DN [3H]Ro154513 DMMBWKL MI TT06RH5 DMMBWKL MN GABA(A) receptor gamma-2 (GABRG2) DMMBWKL MT DTT DMMBWKL MA Inhibitor DMMBWKL RN Antagonist, partial agonist, and full agonist imidazo[1,5-a]quinoxaline amides and carbamates acting through the GABAA/benzodiazepine receptor. J Med Chem. 1994 Mar 18;37(6):758-68. DMMBWKL RU https://pubmed.ncbi.nlm.nih.gov/8145225 DMMBWKL DI DMMBWKL DMMBWKL DN [3H]Ro154513 DMMBWKL MI TTEX6LM DMMBWKL MN GABA(A) receptor gamma-3 (GABRG3) DMMBWKL MT DTT DMMBWKL MA Modulator (allosteric modulator) DMMBWKL RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 415). DMMBWKL RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=415 DMMBWKL DI DMMBWKL DMMBWKL DN [3H]Ro154513 DMMBWKL MI TTNJYV2 DMMBWKL MN Gamma-aminobutyric acid receptor (GAR) DMMBWKL MT DTT DMMBWKL MA Inhibitor DMMBWKL RN Synthesis and pharmacological properties of novel 8-substituted imidazobenzodiazepines: high-affinity, selective probes for alpha 5-containing GABA... J Med Chem. 1996 Apr 26;39(9):1928-34. DMMBWKL RU https://pubmed.ncbi.nlm.nih.gov/8627617 DMK1TRG DI DMK1TRG DMK1TRG DN [3H]robalzotan DMK1TRG MI TTSQIFT DMK1TRG MN 5-HT 1A receptor (HTR1A) DMK1TRG MT DTT DMK1TRG MA Antagonist DMK1TRG RN Receptor binding characteristics of [3H]NAD-299, a new selective 5-HT1A receptor antagonist. Eur J Pharmacol. 1998 Nov 6;360(2-3):219-25. DMK1TRG RU https://pubmed.ncbi.nlm.nih.gov/9851589 DM6IRN4 DI DM6IRN4 DM6IRN4 DN [3H]RX821002 DM6IRN4 MI TTNGILX DM6IRN4 MN Adrenergic receptor alpha-1A (ADRA1A) DM6IRN4 MT DTT DM6IRN4 MA Inhibitor DM6IRN4 RN Alpha-adrenoreceptor reagents. 4. Resolution of some potent selective prejunctional alpha 2-adrenoreceptor antagonists. J Med Chem. 1986 Oct;29(10):2000-3. DM6IRN4 RU https://pubmed.ncbi.nlm.nih.gov/2876101 DM6IRN4 DI DM6IRN4 DM6IRN4 DN [3H]RX821002 DM6IRN4 MI TTBRKXS DM6IRN4 MN Adrenergic receptor alpha-1B (ADRA1B) DM6IRN4 MT DTT DM6IRN4 MA Inhibitor DM6IRN4 RN Alpha-adrenoreceptor reagents. 4. Resolution of some potent selective prejunctional alpha 2-adrenoreceptor antagonists. J Med Chem. 1986 Oct;29(10):2000-3. DM6IRN4 RU https://pubmed.ncbi.nlm.nih.gov/2876101 DM6IRN4 DI DM6IRN4 DM6IRN4 DN [3H]RX821002 DM6IRN4 MI TT34BHT DM6IRN4 MN Adrenergic receptor alpha-1D (ADRA1D) DM6IRN4 MT DTT DM6IRN4 MA Inhibitor DM6IRN4 RN Alpha-adrenoreceptor reagents. 4. Resolution of some potent selective prejunctional alpha 2-adrenoreceptor antagonists. J Med Chem. 1986 Oct;29(10):2000-3. DM6IRN4 RU https://pubmed.ncbi.nlm.nih.gov/2876101 DM6IRN4 DI DM6IRN4 DM6IRN4 DN [3H]RX821002 DM6IRN4 MI TTWG9A4 DM6IRN4 MN Adrenergic receptor alpha-2A (ADRA2A) DM6IRN4 MT DTT DM6IRN4 MA Inhibitor DM6IRN4 RN Alpha-adrenoreceptor reagents. 4. Resolution of some potent selective prejunctional alpha 2-adrenoreceptor antagonists. J Med Chem. 1986 Oct;29(10):2000-3. DM6IRN4 RU https://pubmed.ncbi.nlm.nih.gov/2876101 DM6IRN4 DI DM6IRN4 DM6IRN4 DN [3H]RX821002 DM6IRN4 MI TTWM4TY DM6IRN4 MN Adrenergic receptor alpha-2B (ADRA2B) DM6IRN4 MT DTT DM6IRN4 MA Antagonist DM6IRN4 RN Further characterization of human alpha 2-adrenoceptor subtypes: [3H]RX821002 binding and definition of additional selective drugs. Eur J Pharmacol. 1994 Jan 24;252(1):43-9. DM6IRN4 RU https://pubmed.ncbi.nlm.nih.gov/7908642 DM6IRN4 DI DM6IRN4 DM6IRN4 DN [3H]RX821002 DM6IRN4 MI TT2NUT5 DM6IRN4 MN Adrenergic receptor alpha-2C (ADRA2C) DM6IRN4 MT DTT DM6IRN4 MA Antagonist DM6IRN4 RN Further characterization of human alpha 2-adrenoceptor subtypes: [3H]RX821002 binding and definition of additional selective drugs. Eur J Pharmacol. 1994 Jan 24;252(1):43-9. DM6IRN4 RU https://pubmed.ncbi.nlm.nih.gov/7908642 DMJKWNY DI DMJKWNY DMJKWNY DN [3H]RY80 DMJKWNY MI TTNZPQ1 DMJKWNY MN GABA(A) receptor alpha-5 (GABRA5) DMJKWNY MT DTT DMJKWNY MA Modulator DMJKWNY RN [3H]RY 80: A high-affinity, selective ligand for gamma-aminobutyric acidA receptors containing alpha-5 subunits. J Pharmacol Exp Ther. 1997 Nov;283(2):488-93. DMJKWNY RU https://pubmed.ncbi.nlm.nih.gov/9353361 DM32IAB DI DM32IAB DM32IAB DN [3H]S0139 DM32IAB MI TTKRD0G DM32IAB MN Endothelin A receptor (EDNRA) DM32IAB MT DTT DM32IAB MA Antagonist DM32IAB RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 219). DM32IAB RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=219 DMO9L38 DI DMO9L38 DMO9L38 DN [3H]SB-674042 DMO9L38 MI TT60Q8D DMO9L38 MN Orexin receptor type 1 (HCRTR1) DMO9L38 MT DTT DMO9L38 MA Antagonist DMO9L38 RN Mapping the binding pocket of dual antagonist almorexant to human orexin 1 and orexin 2 receptors: comparison with the selective OX1 antagonist SB-674042 and the selective OX2 antagonist N-ethyl-2-[(6-methoxy-pyridin-3-yl)-(toluene-2-sulfonyl)-amino]-N-pyridin-3-ylmethyl-acetamide (EMPA). Mol Pharmacol. 2010 Jul;78(1):81-93. DMO9L38 RU https://pubmed.ncbi.nlm.nih.gov/20404073 DMO9L38 DI DMO9L38 DMO9L38 DN [3H]SB-674042 DMO9L38 MI TT9N02I DMO9L38 MN Orexin receptor type 2 (HCRTR2) DMO9L38 MT DTT DMO9L38 MA Antagonist DMO9L38 RN Biochemical and electrophysiological characterization of almorexant, a dual orexin 1 receptor (OX1)/orexin 2 receptor (OX2) antagonist: comparison ... Mol Pharmacol. 2009 Sep;76(3):618-31. DMO9L38 RU https://pubmed.ncbi.nlm.nih.gov/19542319 DMUS7EH DI DMUS7EH DMUS7EH DN [3H]SB-733993 DMUS7EH MI TTHJTF7 DMUS7EH MN Glycine transporter GlyT-1 (SLC6A9) DMUS7EH MT DTT DMUS7EH MA Modulator DMUS7EH RN Pharmacological characterisation of the GlyT-1 glycine transporter using two novel radioligands. Neuropharmacology. 2010 Nov;59(6):558-65. DMUS7EH RU https://pubmed.ncbi.nlm.nih.gov/20691713 DM0MLU9 DI DM0MLU9 DM0MLU9 DN [3H]SNAP-7941 DM0MLU9 MI TTX4RTB DM0MLU9 MN Melanin-concentrating hormone receptor 1 (MCHR1) DM0MLU9 MT DTT DM0MLU9 MA Antagonist DM0MLU9 RN Antidepressant, anxiolytic and anorectic effects of a melanin-concentrating hormone-1 receptor antagonist. Nat Med. 2002 Aug;8(8):825-30. DM0MLU9 RU https://pubmed.ncbi.nlm.nih.gov/12118247 DMWHEV8 DI DMWHEV8 DMWHEV8 DN [3H]spiperone DMWHEV8 MI TTSQIFT DMWHEV8 MN 5-HT 1A receptor (HTR1A) DMWHEV8 MT DTT DMWHEV8 MA Inhibitor DMWHEV8 RN Synthesis of (R,S)-trans-8-hydroxy-2-[N-n-propyl-N-(3'-iodo-2'-propenyl)amino]tetral in (trans-8-OH-PIPAT): a new 5-HT1A receptor ligand. J Med Chem. 1993 Oct 15;36(21):3161-5. DMWHEV8 RU https://pubmed.ncbi.nlm.nih.gov/8230102 DMWHEV8 DI DMWHEV8 DMWHEV8 DN [3H]spiperone DMWHEV8 MI TTJQOD7 DMWHEV8 MN 5-HT 2A receptor (HTR2A) DMWHEV8 MT DTT DMWHEV8 MA Inhibitor DMWHEV8 RN Activity of Parthenolide at 5HT2A receptors. J Nat Prod. 1997 Jun;60(6):651-3. DMWHEV8 RU https://pubmed.ncbi.nlm.nih.gov/9214741 DMWHEV8 DI DMWHEV8 DMWHEV8 DN [3H]spiperone DMWHEV8 MI TTJS8PY DMWHEV8 MN 5-HT 6 receptor (HTR6) DMWHEV8 MT DTT DMWHEV8 MA Inhibitor DMWHEV8 RN Higher-end serotonin receptors: 5-HT(5), 5-HT(6), and 5-HT(7). J Med Chem. 2003 Jul 3;46(14):2795-812. DMWHEV8 RU https://pubmed.ncbi.nlm.nih.gov/12825922 DMWHEV8 DI DMWHEV8 DMWHEV8 DN [3H]spiperone DMWHEV8 MI TTO9X1H DMWHEV8 MN 5-HT 7 receptor (HTR7) DMWHEV8 MT DTT DMWHEV8 MA Inhibitor DMWHEV8 RN Higher-end serotonin receptors: 5-HT(5), 5-HT(6), and 5-HT(7). J Med Chem. 2003 Jul 3;46(14):2795-812. DMWHEV8 RU https://pubmed.ncbi.nlm.nih.gov/12825922 DMWHEV8 DI DMWHEV8 DMWHEV8 DN [3H]spiperone DMWHEV8 MI TTNGILX DMWHEV8 MN Adrenergic receptor alpha-1A (ADRA1A) DMWHEV8 MT DTT DMWHEV8 MA Inhibitor DMWHEV8 RN Pharmacophore identification of alpha(1A)-adrenoceptor antagonists. Bioorg Med Chem Lett. 2005 Feb 1;15(3):657-64. DMWHEV8 RU https://pubmed.ncbi.nlm.nih.gov/15664832 DMWHEV8 DI DMWHEV8 DMWHEV8 DN [3H]spiperone DMWHEV8 MI TTEX248 DMWHEV8 MN Dopamine D2 receptor (D2R) DMWHEV8 MT DTT DMWHEV8 MA Antagonist DMWHEV8 RN Regulation of human D(1), d(2(long)), d(2(short)), D(3) and D(4) dopamine receptors by amiloride and amiloride analogues. Br J Pharmacol. 2000 Jul;130(5):1045-59. DMWHEV8 RU https://pubmed.ncbi.nlm.nih.gov/10882389 DMWHEV8 DI DMWHEV8 DMWHEV8 DN [3H]spiperone DMWHEV8 MI TT4C8EA DMWHEV8 MN Dopamine D3 receptor (D3R) DMWHEV8 MT DTT DMWHEV8 MA Antagonist DMWHEV8 RN Regulation of human D(1), d(2(long)), d(2(short)), D(3) and D(4) dopamine receptors by amiloride and amiloride analogues. Br J Pharmacol. 2000 Jul;130(5):1045-59. DMWHEV8 RU https://pubmed.ncbi.nlm.nih.gov/10882389 DMWHEV8 DI DMWHEV8 DMWHEV8 DN [3H]spiperone DMWHEV8 MI TTE0A2F DMWHEV8 MN Dopamine D4 receptor (D4R) DMWHEV8 MT DTT DMWHEV8 MA Antagonist DMWHEV8 RN Differential effects of [3H]nemonapride and [3H]spiperone binding on human dopamine D4 receptors. Neurosci Lett. 1995 Feb 17;186(2-3):145-8. DMWHEV8 RU https://pubmed.ncbi.nlm.nih.gov/7777184 DMWHEV8 DI DMWHEV8 DMWHEV8 DN [3H]spiperone DMWHEV8 MI DTUGYRD DMWHEV8 MN P-glycoprotein 1 (ABCB1) DMWHEV8 MT DTP DMWHEV8 MA Substrate DMWHEV8 RN Human intestinal transporter database: QSAR modeling and virtual profiling of drug uptake, efflux and interactions. Pharm Res. 2013 Apr;30(4):996-1007. DMWHEV8 RU https://doi.org/10.1007/s11095-012-0935-x DM0Y2SC DI DM0Y2SC DM0Y2SC DN [3H]strychnine DM0Y2SC MI TTZ8EM9 DM0Y2SC MN Glycine receptor (GlyR) DM0Y2SC MT DTT DM0Y2SC MA Antagonist DM0Y2SC RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 425). DM0Y2SC RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=425 DM0Y2SC DI DM0Y2SC DM0Y2SC DN [3H]strychnine DM0Y2SC MI TTF45NW DM0Y2SC MN Strychnine-binding glycine receptor (GLRA1) DM0Y2SC MT DTT DM0Y2SC MA Inhibitor DM0Y2SC RN 3-demethoxy-3-glycosylaminothiocolchicines: Synthesis of a new class of putative muscle relaxant compounds. J Med Chem. 2006 Sep 7;49(18):5571-7. DM0Y2SC RU https://pubmed.ncbi.nlm.nih.gov/16942030 DM3MBGV DI DM3MBGV DM3MBGV DN [3H]sumatriptan DM3MBGV MI TTK8CXU DM3MBGV MN 5-HT 1B receptor (HTR1B) DM3MBGV MT DTT DM3MBGV MA Agonist DM3MBGV RN Characterisation of the 5-HT receptor binding profile of eletriptan and kinetics of [3H]eletriptan binding at human 5-HT1B and 5-HT1D receptors. Eur J Pharmacol. 1999 Mar 5;368(2-3):259-68. DM3MBGV RU https://pubmed.ncbi.nlm.nih.gov/10193663 DM3MBGV DI DM3MBGV DM3MBGV DN [3H]sumatriptan DM3MBGV MI TT6MSOK DM3MBGV MN 5-HT 1D receptor (HTR1D) DM3MBGV MT DTT DM3MBGV MA Agonist DM3MBGV RN Characterisation of the 5-HT receptor binding profile of eletriptan and kinetics of [3H]eletriptan binding at human 5-HT1B and 5-HT1D receptors. Eur J Pharmacol. 1999 Mar 5;368(2-3):259-68. DM3MBGV RU https://pubmed.ncbi.nlm.nih.gov/10193663 DMSHW2E DI DMSHW2E DMSHW2E DN [3H]thiamine DMSHW2E MI TT2A1DZ DMSHW2E MN Solute carrier family 19 member 2 (SLC19A2) DMSHW2E MT DTT DMSHW2E MA Modulator DMSHW2E RN Cloning of the human thiamine transporter, a member of the folate transporter family. J Biol Chem. 1999 Nov 5;274(45):31925-9. DMSHW2E RU https://pubmed.ncbi.nlm.nih.gov/10542220 DMSHW2E DI DMSHW2E DMSHW2E DN [3H]thiamine DMSHW2E MI TT9BTWM DMSHW2E MN Solute carrier family 19 member 3 (SLC19A3) DMSHW2E MT DTT DMSHW2E MA Modulator DMSHW2E RN SLC19A3 encodes a second thiamine transporter ThTr2. Biochim Biophys Acta. 2001 Nov 29;1537(3):175-8. DMSHW2E RU https://pubmed.ncbi.nlm.nih.gov/11731220 DM6RSZ9 DI DM6RSZ9 DM6RSZ9 DN [3H]U69593 DM6RSZ9 MI TTQW87Y DM6RSZ9 MN Opioid receptor kappa (OPRK1) DM6RSZ9 MT DTT DM6RSZ9 MA Agonist DM6RSZ9 RN [3H]U-69593 a highly selective ligand for the opioid kappa receptor. Eur J Pharmacol. 1985 Feb 26;109(2):281-4. DM6RSZ9 RU https://pubmed.ncbi.nlm.nih.gov/2986999 DM6RSZ9 DI DM6RSZ9 DM6RSZ9 DN [3H]U69593 DM6RSZ9 MI TTKWM86 DM6RSZ9 MN Opioid receptor mu (MOP) DM6RSZ9 MT DTT DM6RSZ9 MA Inhibitor DM6RSZ9 RN Opiate receptor binding properties of morphine-, dihydromorphine-, and codeine 6-O-sulfate ester congeners. Bioorg Med Chem Lett. 2006 Aug 15;16(16):4291-5. DM6RSZ9 RU https://pubmed.ncbi.nlm.nih.gov/16777416 DM3MK8S DI DM3MK8S DM3MK8S DN [3H]vesamicol DM3MK8S MI TTV8KWS DM3MK8S MN Vesicular acetylcholine transporter (SLC18A3) DM3MK8S MT DTT DM3MK8S MA Modulator DM3MK8S RN Active transport of acetylcholine by the human vesicular acetylcholine transporter. J Biol Chem. 1996 Nov 1;271(44):27229-32. DM3MK8S RU https://pubmed.ncbi.nlm.nih.gov/8910293 DMI8RU0 DI DMI8RU0 DMI8RU0 DN [3H]WIN35428 DMI8RU0 MI TTVBI8W DMI8RU0 MN Dopamine transporter (DAT) DMI8RU0 MT DTT DMI8RU0 MA Inhibitor DMI8RU0 RN Pharmacological heterogeneity of the cloned and native human dopamine transporter: disassociation of [3H]WIN 35,428 and [3H]GBR 12,935 binding. Mol Pharmacol. 1994 Jan;45(1):125-35. DMI8RU0 RU https://pubmed.ncbi.nlm.nih.gov/8302271 DMI8RU0 DI DMI8RU0 DMI8RU0 DN [3H]WIN35428 DMI8RU0 MI TTAWNKZ DMI8RU0 MN Norepinephrine transporter (NET) DMI8RU0 MT DTT DMI8RU0 MA Inhibitor DMI8RU0 RN 3 alpha-(4'-substituted phenyl)tropane-2 beta-carboxylic acid methyl esters: novel ligands with high affinity and selectivity at the dopamine trans... J Med Chem. 1996 Oct 11;39(21):4139-41. DMI8RU0 RU https://pubmed.ncbi.nlm.nih.gov/8863789 DMI8RU0 DI DMI8RU0 DMI8RU0 DN [3H]WIN35428 DMI8RU0 MI TT3ROYC DMI8RU0 MN Serotonin transporter (SERT) DMI8RU0 MT DTT DMI8RU0 MA Inhibitor DMI8RU0 RN 3 alpha-(4'-substituted phenyl)tropane-2 beta-carboxylic acid methyl esters: novel ligands with high affinity and selectivity at the dopamine trans... J Med Chem. 1996 Oct 11;39(21):4139-41. DMI8RU0 RU https://pubmed.ncbi.nlm.nih.gov/8863789 DM0TRAZ DI DM0TRAZ DM0TRAZ DN [3H]WIN55212-2 DM0TRAZ MI TT6OEDT DM0TRAZ MN Cannabinoid receptor 1 (CB1) DM0TRAZ MT DTT DM0TRAZ MA Agonist DM0TRAZ RN Ligand binding and modulation of cyclic AMP levels depend on the chemical nature of residue 192 of the human cannabinoid receptor 1. J Neurochem. 1998 Jan;70(1):366-73. DM0TRAZ RU https://pubmed.ncbi.nlm.nih.gov/9422383 DM0TRAZ DI DM0TRAZ DM0TRAZ DN [3H]WIN55212-2 DM0TRAZ MI TTMSFAW DM0TRAZ MN Cannabinoid receptor 2 (CB2) DM0TRAZ MT DTT DM0TRAZ MA Agonist DM0TRAZ RN Activation of the human peripheral cannabinoid receptor results in inhibition of adenylyl cyclase. Mol Pharmacol. 1995 Aug;48(2):352-61. DM0TRAZ RU https://pubmed.ncbi.nlm.nih.gov/7651369 DMKU4YQ DI DMKU4YQ DMKU4YQ DN [3H]ZM 241385 DMKU4YQ MI TTNE7KG DMKU4YQ MN Adenosine A2b receptor (ADORA2B) DMKU4YQ MT DTT DMKU4YQ MA Antagonist DMKU4YQ RN Use of the triazolotriazine [3H]ZM 241385 as a radioligand at recombinant human A2B adenosine receptors. Drug Des Discov. 1999 Nov;16(3):217-26. DMKU4YQ RU https://pubmed.ncbi.nlm.nih.gov/10624567 DMNCAE9 DI DMNCAE9 DMNCAE9 DN [4-(3-Adamantan-1-yl-ureido)-phenyl]-acetic acid DMNCAE9 MI TT7WVHI DMNCAE9 MN Soluble epoxide hydrolase (EPHX2) DMNCAE9 MT DTT DMNCAE9 MA Inhibitor DMNCAE9 RN Salicylate-urea-based soluble epoxide hydrolase inhibitors with high metabolic and chemical stabilities. Bioorg Med Chem Lett. 2009 Mar 15;19(6):1784-9. DMNCAE9 RU https://pubmed.ncbi.nlm.nih.gov/19216074 DM7JSQL DI DM7JSQL DM7JSQL DN [4',4''']-biflavone DM7JSQL MI TTT1JVS DM7JSQL MN Cytosolic phospholipase A2 (GIVA cPLA2) DM7JSQL MT DTT DM7JSQL MA Inhibitor DM7JSQL RN Inhibitory effect of synthetic C-C biflavones on various phospholipase A(2)s activity. Bioorg Med Chem. 2007 Nov 15;15(22):7138-43. DM7JSQL RU https://pubmed.ncbi.nlm.nih.gov/17826099 DM86Z4H DI DM86Z4H DM86Z4H DN [4Aph(CO-(C2H4O)3-C2H4-NH-CO-NH-OCH3)5]degarelix DM86Z4H MI TT8R70G DM86Z4H MN Gonadotropin-releasing hormone receptor (GNRHR) DM86Z4H MT DTT DM86Z4H MA Inhibitor DM86Z4H RN Novel analogues of degarelix incorporating hydroxy-, methoxy-, and pegylated-urea moieties at positions 3, 5, 6 and the N-terminus. Part III. J Med Chem. 2006 Jun 15;49(12):3536-43. DM86Z4H RU https://pubmed.ncbi.nlm.nih.gov/16759096 DM4IXJA DI DM4IXJA DM4IXJA DN [4Aph(CO-NH-(C2H4O)2-C2H5)5]degarelix DM4IXJA MI TT8R70G DM4IXJA MN Gonadotropin-releasing hormone receptor (GNRHR) DM4IXJA MT DTT DM4IXJA MA Inhibitor DM4IXJA RN Novel analogues of degarelix incorporating hydroxy-, methoxy-, and pegylated-urea moieties at positions 3, 5, 6 and the N-terminus. Part III. J Med Chem. 2006 Jun 15;49(12):3536-43. DM4IXJA RU https://pubmed.ncbi.nlm.nih.gov/16759096 DM57TIU DI DM57TIU DM57TIU DN [4Aph(CO-NH-OCH3)5,D-4Aph(CO-NH-OCH3)6]degarelix DM57TIU MI TT8R70G DM57TIU MN Gonadotropin-releasing hormone receptor (GNRHR) DM57TIU MT DTT DM57TIU MA Inhibitor DM57TIU RN Novel analogues of degarelix incorporating hydroxy-, methoxy-, and pegylated-urea moieties at positions 3, 5, 6 and the N-terminus. Part III. J Med Chem. 2006 Jun 15;49(12):3536-43. DM57TIU RU https://pubmed.ncbi.nlm.nih.gov/16759096 DM6C8K1 DI DM6C8K1 DM6C8K1 DN [4Aph(CO-NH-OCH3)5]degarelix DM6C8K1 MI TT8R70G DM6C8K1 MN Gonadotropin-releasing hormone receptor (GNRHR) DM6C8K1 MT DTT DM6C8K1 MA Inhibitor DM6C8K1 RN Novel analogues of degarelix incorporating hydroxy-, methoxy-, and pegylated-urea moieties at positions 3, 5, 6 and the N-terminus. Part III. J Med Chem. 2006 Jun 15;49(12):3536-43. DM6C8K1 RU https://pubmed.ncbi.nlm.nih.gov/16759096 DMFMB31 DI DMFMB31 DMFMB31 DN [4Aph(CO-NH-OH)5]degarelix DMFMB31 MI TT8R70G DMFMB31 MN Gonadotropin-releasing hormone receptor (GNRHR) DMFMB31 MT DTT DMFMB31 MA Inhibitor DMFMB31 RN Novel analogues of degarelix incorporating hydroxy-, methoxy-, and pegylated-urea moieties at positions 3, 5, 6 and the N-terminus. Part III. J Med Chem. 2006 Jun 15;49(12):3536-43. DMFMB31 RU https://pubmed.ncbi.nlm.nih.gov/16759096 DMA9PW7 DI DMA9PW7 DMA9PW7 DN [6,3''']biflavone DMA9PW7 MI TTT1JVS DMA9PW7 MN Cytosolic phospholipase A2 (GIVA cPLA2) DMA9PW7 MT DTT DMA9PW7 MA Inhibitor DMA9PW7 RN Inhibitory effect of synthetic C-C biflavones on various phospholipase A(2)s activity. Bioorg Med Chem. 2007 Nov 15;15(22):7138-43. DMA9PW7 RU https://pubmed.ncbi.nlm.nih.gov/17826099 DMVOX4L DI DMVOX4L DMVOX4L DN [6,4''']biflavone DMVOX4L MI TTT1JVS DMVOX4L MN Cytosolic phospholipase A2 (GIVA cPLA2) DMVOX4L MT DTT DMVOX4L MA Inhibitor DMVOX4L RN Inhibitory effect of synthetic C-C biflavones on various phospholipase A(2)s activity. Bioorg Med Chem. 2007 Nov 15;15(22):7138-43. DMVOX4L RU https://pubmed.ncbi.nlm.nih.gov/17826099 DMUCAXT DI DMUCAXT DMUCAXT DN [Aib7]OT DMUCAXT MI TTSCIUP DMUCAXT MN Oxytocin receptor (OTR) DMUCAXT MT DTT DMUCAXT MA Inhibitor DMUCAXT RN Synthesis and biological activity of oxytocin analogues containing conformationally-restricted residues in position 7. Eur J Med Chem. 2007 Jun;42(6):799-806. DMUCAXT RU https://pubmed.ncbi.nlm.nih.gov/17316912 DMHJEQL DI DMHJEQL DMHJEQL DN [Asp6,Lys10]N/OFQ(1-13)NH2 DMHJEQL MI TTNT7K8 DMHJEQL MN Nociceptin receptor (OPRL1) DMHJEQL MT DTT DMHJEQL MA Inhibitor DMHJEQL RN High affinity conformationally constrained nociceptin/orphanin FQ(1-13) amide analogues. J Med Chem. 2008 Aug 14;51(15):4385-7. DMHJEQL RU https://pubmed.ncbi.nlm.nih.gov/18624395 DMN70VT DI DMN70VT DMN70VT DN [Au(CN)2]- DMN70VT MI TTHQPL7 DMN70VT MN Carbonic anhydrase I (CA-I) DMN70VT MT DTT DMN70VT MA Inhibitor DMN70VT RN Carbonic anhydrase inhibitors. Inhibition of isozymes I, II, IV, V and IX with complex fluorides, chlorides and cyanides. Bioorg Med Chem Lett. 2005 Apr 1;15(7):1909-13. DMN70VT RU https://pubmed.ncbi.nlm.nih.gov/15780631 DMB78GP DI DMB78GP DMB78GP DN [Bpa1]AngII DMB78GP MI TT8DBY3 DMB78GP MN Angiotensin II receptor type-1 (AGTR1) DMB78GP MT DTT DMB78GP MA Inhibitor DMB78GP RN The amino-terminus of angiotensin II contacts several ectodomains of the angiotensin II receptor AT1. J Med Chem. 2010 Mar 11;53(5):2063-75. DMB78GP RU https://pubmed.ncbi.nlm.nih.gov/20146480 DMV6NP1 DI DMV6NP1 DMV6NP1 DN [Cu(CN)2]- DMV6NP1 MI TTHQPL7 DMV6NP1 MN Carbonic anhydrase I (CA-I) DMV6NP1 MT DTT DMV6NP1 MA Inhibitor DMV6NP1 RN Carbonic anhydrase inhibitors. Inhibition of isozymes I, II, IV, V and IX with complex fluorides, chlorides and cyanides. Bioorg Med Chem Lett. 2005 Apr 1;15(7):1909-13. DMV6NP1 RU https://pubmed.ncbi.nlm.nih.gov/15780631 DMV6NP1 DI DMV6NP1 DMV6NP1 DN [Cu(CN)2]- DMV6NP1 MI TTZHA0O DMV6NP1 MN Carbonic anhydrase IV (CA-IV) DMV6NP1 MT DTT DMV6NP1 MA Inhibitor DMV6NP1 RN Carbonic anhydrase inhibitors. Inhibition of isozymes I, II, IV, V and IX with complex fluorides, chlorides and cyanides. Bioorg Med Chem Lett. 2005 Apr 1;15(7):1909-13. DMV6NP1 RU https://pubmed.ncbi.nlm.nih.gov/15780631 DMQ8CD3 DI DMQ8CD3 DMQ8CD3 DN [Cyclopentyl-(2-nitro-benzoyl)-amino]-acetic acid DMQ8CD3 MI TTL69WB DMQ8CD3 MN Angiotensin-converting enzyme (ACE) DMQ8CD3 MT DTT DMQ8CD3 MA Inhibitor DMQ8CD3 RN Angiotensin converting enzyme inhibitors. (Mercaptoaroyl)amino acids. J Med Chem. 1985 Mar;28(3):328-32. DMQ8CD3 RU https://pubmed.ncbi.nlm.nih.gov/2983075 DMWFGBC DI DMWFGBC DMWFGBC DN [Cys-Trp-Arg-Nva-Arg-Tyr-NH2]2 DMWFGBC MI TTRK9JT DMWFGBC MN Neuropeptide Y receptor type 1 (NPY1R) DMWFGBC MT DTT DMWFGBC MA Inhibitor DMWFGBC RN Neuropeptide Y (NPY) Y4 receptor selective agonists based on NPY(32-36): development of an anorectic Y4 receptor selective agonist with picomolar a... J Med Chem. 2006 Apr 20;49(8):2661-5. DMWFGBC RU https://pubmed.ncbi.nlm.nih.gov/16610810 DMWFGBC DI DMWFGBC DMWFGBC DN [Cys-Trp-Arg-Nva-Arg-Tyr-NH2]2 DMWFGBC MI TTW4N16 DMWFGBC MN Neuropeptide Y receptor type 4 (NPY4R) DMWFGBC MT DTT DMWFGBC MA Inhibitor DMWFGBC RN Neuropeptide Y (NPY) Y4 receptor selective agonists based on NPY(32-36): development of an anorectic Y4 receptor selective agonist with picomolar a... J Med Chem. 2006 Apr 20;49(8):2661-5. DMWFGBC RU https://pubmed.ncbi.nlm.nih.gov/16610810 DMFKTJ8 DI DMFKTJ8 DMFKTJ8 DN [D-4Aph(CO-NH-(C2H4O)2-C2H5)6]degarelix DMFKTJ8 MI TT8R70G DMFKTJ8 MN Gonadotropin-releasing hormone receptor (GNRHR) DMFKTJ8 MT DTT DMFKTJ8 MA Inhibitor DMFKTJ8 RN Novel analogues of degarelix incorporating hydroxy-, methoxy-, and pegylated-urea moieties at positions 3, 5, 6 and the N-terminus. Part III. J Med Chem. 2006 Jun 15;49(12):3536-43. DMFKTJ8 RU https://pubmed.ncbi.nlm.nih.gov/16759096 DMR7TEQ DI DMR7TEQ DMR7TEQ DN [D-4Aph(CO-NH-OCH3)6]degarelix DMR7TEQ MI TT8R70G DMR7TEQ MN Gonadotropin-releasing hormone receptor (GNRHR) DMR7TEQ MT DTT DMR7TEQ MA Inhibitor DMR7TEQ RN Novel analogues of degarelix incorporating hydroxy-, methoxy-, and pegylated-urea moieties at positions 3, 5, 6 and the N-terminus. Part III. J Med Chem. 2006 Jun 15;49(12):3536-43. DMR7TEQ RU https://pubmed.ncbi.nlm.nih.gov/16759096 DMMVIX7 DI DMMVIX7 DMMVIX7 DN [D-4Aph(CO-NH-OH)6]degarelix DMMVIX7 MI TT8R70G DMMVIX7 MN Gonadotropin-releasing hormone receptor (GNRHR) DMMVIX7 MT DTT DMMVIX7 MA Inhibitor DMMVIX7 RN Novel analogues of degarelix incorporating hydroxy-, methoxy-, and pegylated-urea moieties at positions 3, 5, 6 and the N-terminus. Part III. J Med Chem. 2006 Jun 15;49(12):3536-43. DMMVIX7 RU https://pubmed.ncbi.nlm.nih.gov/16759096 DM18ZNJ DI DM18ZNJ DM18ZNJ DN [D-Ala2]Met-enkephalinamide DM18ZNJ MI TTKWM86 DM18ZNJ MN Opioid receptor mu (MOP) DM18ZNJ MT DTT DM18ZNJ MA Inhibitor DM18ZNJ RN Synthesis and biological evaluation of a metazocine-containing enkephalinamide. Evidence for nonidentical roles of the tyramine moiety in opiates a... J Med Chem. 1982 Dec;25(12):1423-7. DM18ZNJ RU https://pubmed.ncbi.nlm.nih.gov/7154002 DMSGW51 DI DMSGW51 DMSGW51 DN [D-Asp7,Lys10]N/OFQ(1-13)NH2 DMSGW51 MI TTNT7K8 DMSGW51 MN Nociceptin receptor (OPRL1) DMSGW51 MT DTT DMSGW51 MA Inhibitor DMSGW51 RN High affinity conformationally constrained nociceptin/orphanin FQ(1-13) amide analogues. J Med Chem. 2008 Aug 14;51(15):4385-7. DMSGW51 RU https://pubmed.ncbi.nlm.nih.gov/18624395 DM23GCK DI DM23GCK DM23GCK DN [Dcp1]Dyn A(1-11)-NH2 DM23GCK MI TT27RFC DM23GCK MN Opioid receptor delta (OPRD1) DM23GCK MT DTT DM23GCK MA Inhibitor DM23GCK RN Replacement of the N-terminal tyrosine residue in opioid peptides with 3-(2,6-dimethyl-4-carbamoylphenyl)propanoic acid (Dcp) results in novel opio... J Med Chem. 2006 Aug 24;49(17):5382-5. DM23GCK RU https://pubmed.ncbi.nlm.nih.gov/16913729 DM23GCK DI DM23GCK DM23GCK DN [Dcp1]Dyn A(1-11)-NH2 DM23GCK MI TTQW87Y DM23GCK MN Opioid receptor kappa (OPRK1) DM23GCK MT DTT DM23GCK MA Inhibitor DM23GCK RN Replacement of the N-terminal tyrosine residue in opioid peptides with 3-(2,6-dimethyl-4-carbamoylphenyl)propanoic acid (Dcp) results in novel opio... J Med Chem. 2006 Aug 24;49(17):5382-5. DM23GCK RU https://pubmed.ncbi.nlm.nih.gov/16913729 DM23GCK DI DM23GCK DM23GCK DN [Dcp1]Dyn A(1-11)-NH2 DM23GCK MI TTKWM86 DM23GCK MN Opioid receptor mu (MOP) DM23GCK MT DTT DM23GCK MA Inhibitor DM23GCK RN Replacement of the N-terminal tyrosine residue in opioid peptides with 3-(2,6-dimethyl-4-carbamoylphenyl)propanoic acid (Dcp) results in novel opio... J Med Chem. 2006 Aug 24;49(17):5382-5. DM23GCK RU https://pubmed.ncbi.nlm.nih.gov/16913729 DMEZKX0 DI DMEZKX0 DMEZKX0 DN [D-Dab(CO-NH-OCH3)3]degarelix DMEZKX0 MI TT8R70G DMEZKX0 MN Gonadotropin-releasing hormone receptor (GNRHR) DMEZKX0 MT DTT DMEZKX0 MA Inhibitor DMEZKX0 RN Novel analogues of degarelix incorporating hydroxy-, methoxy-, and pegylated-urea moieties at positions 3, 5, 6 and the N-terminus. Part III. J Med Chem. 2006 Jun 15;49(12):3536-43. DMEZKX0 RU https://pubmed.ncbi.nlm.nih.gov/16759096 DMRVPN1 DI DMRVPN1 DMRVPN1 DN [D-Dab(CO-NH-OH)3]degarelix DMRVPN1 MI TT8R70G DMRVPN1 MN Gonadotropin-releasing hormone receptor (GNRHR) DMRVPN1 MT DTT DMRVPN1 MA Inhibitor DMRVPN1 RN Novel analogues of degarelix incorporating hydroxy-, methoxy-, and pegylated-urea moieties at positions 3, 5, 6 and the N-terminus. Part III. J Med Chem. 2006 Jun 15;49(12):3536-43. DMRVPN1 RU https://pubmed.ncbi.nlm.nih.gov/16759096 DM5ZR4S DI DM5ZR4S DM5ZR4S DN [D-Dap(CO-NH-OCH3)3]degarelix DM5ZR4S MI TT8R70G DM5ZR4S MN Gonadotropin-releasing hormone receptor (GNRHR) DM5ZR4S MT DTT DM5ZR4S MA Inhibitor DM5ZR4S RN Novel analogues of degarelix incorporating hydroxy-, methoxy-, and pegylated-urea moieties at positions 3, 5, 6 and the N-terminus. Part III. J Med Chem. 2006 Jun 15;49(12):3536-43. DM5ZR4S RU https://pubmed.ncbi.nlm.nih.gov/16759096 DMS0LFT DI DMS0LFT DMS0LFT DN [D-Dap(CO-NH-OH)3]degarelix DMS0LFT MI TT8R70G DMS0LFT MN Gonadotropin-releasing hormone receptor (GNRHR) DMS0LFT MT DTT DMS0LFT MA Inhibitor DMS0LFT RN Novel analogues of degarelix incorporating hydroxy-, methoxy-, and pegylated-urea moieties at positions 3, 5, 6 and the N-terminus. Part III. J Med Chem. 2006 Jun 15;49(12):3536-43. DMS0LFT RU https://pubmed.ncbi.nlm.nih.gov/16759096 DMEL0SZ DI DMEL0SZ DMEL0SZ DN [des-Arg9]bradykinin DMEL0SZ MI TTGY8IW DMEL0SZ MN B2 bradykinin receptor (BDKRB2) DMEL0SZ MT DTT DMEL0SZ MA Agonist DMEL0SZ RN Stable expression of human kinin B1 receptor in 293 cells: pharmacological and functional characterization. Br J Pharmacol. 1997 Sep;122(2):393-9. DMEL0SZ RU https://pubmed.ncbi.nlm.nih.gov/9313952 DM1EPZB DI DM1EPZB DM1EPZB DN [des-His1,Tyr5,Glu9,D-Ala10]glucagon-NH2 DM1EPZB MI TT9O6WS DM1EPZB MN Glucagon receptor (GCGR) DM1EPZB MT DTT DM1EPZB MA Inhibitor DM1EPZB RN Topographical amino acid substitution in position 10 of glucagon leads to antagonists/partial agonists with greater binding differences. J Med Chem. 1996 Jun 21;39(13):2449-55. DM1EPZB RU https://pubmed.ncbi.nlm.nih.gov/8691441 DM06Q2V DI DM06Q2V DM06Q2V DN [des-His1,Tyr5,Glu9,D-Phe10]glucagon-NH2 DM06Q2V MI TT9O6WS DM06Q2V MN Glucagon receptor (GCGR) DM06Q2V MT DTT DM06Q2V MA Inhibitor DM06Q2V RN Topographical amino acid substitution in position 10 of glucagon leads to antagonists/partial agonists with greater binding differences. J Med Chem. 1996 Jun 21;39(13):2449-55. DM06Q2V RU https://pubmed.ncbi.nlm.nih.gov/8691441 DMFLVED DI DMFLVED DMFLVED DN [des-His1,Tyr5,Glu9,D-Tyr10]glucagon-NH2 DMFLVED MI TT9O6WS DMFLVED MN Glucagon receptor (GCGR) DMFLVED MT DTT DMFLVED MA Inhibitor DMFLVED RN Topographical amino acid substitution in position 10 of glucagon leads to antagonists/partial agonists with greater binding differences. J Med Chem. 1996 Jun 21;39(13):2449-55. DMFLVED RU https://pubmed.ncbi.nlm.nih.gov/8691441 DM93I0B DI DM93I0B DM93I0B DN [des-His1,Tyr5,Glu9]glucagon-NH2 DM93I0B MI TT9O6WS DM93I0B MN Glucagon receptor (GCGR) DM93I0B MT DTT DM93I0B MA Inhibitor DM93I0B RN Topographical amino acid substitution in position 10 of glucagon leads to antagonists/partial agonists with greater binding differences. J Med Chem. 1996 Jun 21;39(13):2449-55. DM93I0B RU https://pubmed.ncbi.nlm.nih.gov/8691441 DMP1D7Q DI DMP1D7Q DMP1D7Q DN [D-Gln3,D-Ncy(isopropyl)7]acyline DMP1D7Q MI TT8R70G DMP1D7Q MN Gonadotropin-releasing hormone receptor (GNRHR) DMP1D7Q MT DTT DMP1D7Q MA Inhibitor DMP1D7Q RN Structure-activity relationship studies of gonadotropin-releasing hormone antagonists containing S-aryl/alkyl norcysteines and their oxidized deriv... J Med Chem. 2007 May 3;50(9):2067-77. DMP1D7Q RU https://pubmed.ncbi.nlm.nih.gov/17402723 DMFAX1Q DI DMFAX1Q DMFAX1Q DN [D-Gln3,D-Ncy(SO,isopropyl)7]acyline DMFAX1Q MI TT8R70G DMFAX1Q MN Gonadotropin-releasing hormone receptor (GNRHR) DMFAX1Q MT DTT DMFAX1Q MA Inhibitor DMFAX1Q RN Structure-activity relationship studies of gonadotropin-releasing hormone antagonists containing S-aryl/alkyl norcysteines and their oxidized deriv... J Med Chem. 2007 May 3;50(9):2067-77. DMFAX1Q RU https://pubmed.ncbi.nlm.nih.gov/17402723 DM3H0CX DI DM3H0CX DM3H0CX DN [D-Gln3,D-Ncy(SO2,isopropyl)7]acyline DM3H0CX MI TT8R70G DM3H0CX MN Gonadotropin-releasing hormone receptor (GNRHR) DM3H0CX MT DTT DM3H0CX MA Inhibitor DM3H0CX RN Structure-activity relationship studies of gonadotropin-releasing hormone antagonists containing S-aryl/alkyl norcysteines and their oxidized deriv... J Med Chem. 2007 May 3;50(9):2067-77. DM3H0CX RU https://pubmed.ncbi.nlm.nih.gov/17402723 DMMEQ3R DI DMMEQ3R DMMEQ3R DN [D-Gln3,Ncy(isopropyl)7]acyline DMMEQ3R MI TT8R70G DMMEQ3R MN Gonadotropin-releasing hormone receptor (GNRHR) DMMEQ3R MT DTT DMMEQ3R MA Inhibitor DMMEQ3R RN Structure-activity relationship studies of gonadotropin-releasing hormone antagonists containing S-aryl/alkyl norcysteines and their oxidized deriv... J Med Chem. 2007 May 3;50(9):2067-77. DMMEQ3R RU https://pubmed.ncbi.nlm.nih.gov/17402723 DM2QDXW DI DM2QDXW DM2QDXW DN [D-Gln3,Ncy(SO,isopropyl)7]acyline DM2QDXW MI TT8R70G DM2QDXW MN Gonadotropin-releasing hormone receptor (GNRHR) DM2QDXW MT DTT DM2QDXW MA Inhibitor DM2QDXW RN Structure-activity relationship studies of gonadotropin-releasing hormone antagonists containing S-aryl/alkyl norcysteines and their oxidized deriv... J Med Chem. 2007 May 3;50(9):2067-77. DM2QDXW RU https://pubmed.ncbi.nlm.nih.gov/17402723 DMJSCO7 DI DMJSCO7 DMJSCO7 DN [D-Gln3,Ncy(SO2,isopropyl)7]acyline DMJSCO7 MI TT8R70G DMJSCO7 MN Gonadotropin-releasing hormone receptor (GNRHR) DMJSCO7 MT DTT DMJSCO7 MA Inhibitor DMJSCO7 RN Structure-activity relationship studies of gonadotropin-releasing hormone antagonists containing S-aryl/alkyl norcysteines and their oxidized deriv... J Med Chem. 2007 May 3;50(9):2067-77. DMJSCO7 RU https://pubmed.ncbi.nlm.nih.gov/17402723 DMAFNTL DI DMAFNTL DMAFNTL DN [D-Ncy(2-naphthyl)1]acyline DMAFNTL MI TT8R70G DMAFNTL MN Gonadotropin-releasing hormone receptor (GNRHR) DMAFNTL MT DTT DMAFNTL MA Inhibitor DMAFNTL RN Structure-activity relationship studies of gonadotropin-releasing hormone antagonists containing S-aryl/alkyl norcysteines and their oxidized deriv... J Med Chem. 2007 May 3;50(9):2067-77. DMAFNTL RU https://pubmed.ncbi.nlm.nih.gov/17402723 DMVBTAM DI DMVBTAM DMVBTAM DN [D-Ncy(isopropyl)7]acyline DMVBTAM MI TT8R70G DMVBTAM MN Gonadotropin-releasing hormone receptor (GNRHR) DMVBTAM MT DTT DMVBTAM MA Inhibitor DMVBTAM RN Structure-activity relationship studies of gonadotropin-releasing hormone antagonists containing S-aryl/alkyl norcysteines and their oxidized deriv... J Med Chem. 2007 May 3;50(9):2067-77. DMVBTAM RU https://pubmed.ncbi.nlm.nih.gov/17402723 DM9TORW DI DM9TORW DM9TORW DN [D-Ncy(methyl)10] acyline DM9TORW MI TT8R70G DM9TORW MN Gonadotropin-releasing hormone receptor (GNRHR) DM9TORW MT DTT DM9TORW MA Inhibitor DM9TORW RN Structure-activity relationship studies of gonadotropin-releasing hormone antagonists containing S-aryl/alkyl norcysteines and their oxidized deriv... J Med Chem. 2007 May 3;50(9):2067-77. DM9TORW RU https://pubmed.ncbi.nlm.nih.gov/17402723 DM63FN5 DI DM63FN5 DM63FN5 DN [D-Ncy(methyl)4]acyline DM63FN5 MI TT8R70G DM63FN5 MN Gonadotropin-releasing hormone receptor (GNRHR) DM63FN5 MT DTT DM63FN5 MA Inhibitor DM63FN5 RN Structure-activity relationship studies of gonadotropin-releasing hormone antagonists containing S-aryl/alkyl norcysteines and their oxidized deriv... J Med Chem. 2007 May 3;50(9):2067-77. DM63FN5 RU https://pubmed.ncbi.nlm.nih.gov/17402723 DME9AN4 DI DME9AN4 DME9AN4 DN [D-Ncy(SO,isopropyl)7]acyline DME9AN4 MI TT8R70G DME9AN4 MN Gonadotropin-releasing hormone receptor (GNRHR) DME9AN4 MT DTT DME9AN4 MA Inhibitor DME9AN4 RN Structure-activity relationship studies of gonadotropin-releasing hormone antagonists containing S-aryl/alkyl norcysteines and their oxidized deriv... J Med Chem. 2007 May 3;50(9):2067-77. DME9AN4 RU https://pubmed.ncbi.nlm.nih.gov/17402723 DMT2X98 DI DMT2X98 DMT2X98 DN [D-Ncy(SO,methyl)10]acyline DMT2X98 MI TT8R70G DMT2X98 MN Gonadotropin-releasing hormone receptor (GNRHR) DMT2X98 MT DTT DMT2X98 MA Inhibitor DMT2X98 RN Structure-activity relationship studies of gonadotropin-releasing hormone antagonists containing S-aryl/alkyl norcysteines and their oxidized deriv... J Med Chem. 2007 May 3;50(9):2067-77. DMT2X98 RU https://pubmed.ncbi.nlm.nih.gov/17402723 DM6HEXG DI DM6HEXG DM6HEXG DN [D-Ncy(SO,methyl)4]acyline DM6HEXG MI TT8R70G DM6HEXG MN Gonadotropin-releasing hormone receptor (GNRHR) DM6HEXG MT DTT DM6HEXG MA Inhibitor DM6HEXG RN Structure-activity relationship studies of gonadotropin-releasing hormone antagonists containing S-aryl/alkyl norcysteines and their oxidized deriv... J Med Chem. 2007 May 3;50(9):2067-77. DM6HEXG RU https://pubmed.ncbi.nlm.nih.gov/17402723 DME8W3R DI DME8W3R DME8W3R DN [D-Tic7]OT DME8W3R MI TTSCIUP DME8W3R MN Oxytocin receptor (OTR) DME8W3R MT DTT DME8W3R MA Inhibitor DME8W3R RN Synthesis and biological activity of oxytocin analogues containing conformationally-restricted residues in position 7. Eur J Med Chem. 2007 Jun;42(6):799-806. DME8W3R RU https://pubmed.ncbi.nlm.nih.gov/17316912 DMWGADP DI DMWGADP DMWGADP DN [Fe(CN)6]4- DMWGADP MI TTZHA0O DMWGADP MN Carbonic anhydrase IV (CA-IV) DMWGADP MT DTT DMWGADP MA Inhibitor DMWGADP RN Carbonic anhydrase inhibitors. Inhibition of isozymes I, II, IV, V and IX with complex fluorides, chlorides and cyanides. Bioorg Med Chem Lett. 2005 Apr 1;15(7):1909-13. DMWGADP RU https://pubmed.ncbi.nlm.nih.gov/15780631 DMZM3GB DI DMZM3GB DMZM3GB DN [Gly(But)7]OT DMZM3GB MI TTSCIUP DMZM3GB MN Oxytocin receptor (OTR) DMZM3GB MT DTT DMZM3GB MA Inhibitor DMZM3GB RN Synthesis and biological activity of oxytocin analogues containing conformationally-restricted residues in position 7. Eur J Med Chem. 2007 Jun;42(6):799-806. DMZM3GB RU https://pubmed.ncbi.nlm.nih.gov/17316912 DM9SP2U DI DM9SP2U DM9SP2U DN [Gly8, aib22]GLP-1(7-37)-NH2 DM9SP2U MI TTVIMDE DM9SP2U MN Glucagon-like peptide 1 receptor (GLP1R) DM9SP2U MT DTT DM9SP2U MA Inhibitor DM9SP2U RN Design and synthesis of conformationally constrained glucagon-like peptide-1 derivatives with increased plasma stability and prolonged in vivo acti... J Med Chem. 2008 May 8;51(9):2758-65. DM9SP2U RU https://pubmed.ncbi.nlm.nih.gov/18412318 DMO8U3S DI DMO8U3S DMO8U3S DN [Gly8,Glu22]GLP-1(7,37)-NH2 DMO8U3S MI TTVIMDE DMO8U3S MN Glucagon-like peptide 1 receptor (GLP1R) DMO8U3S MT DTT DMO8U3S MA Inhibitor DMO8U3S RN Design and synthesis of conformationally constrained glucagon-like peptide-1 derivatives with increased plasma stability and prolonged in vivo acti... J Med Chem. 2008 May 8;51(9):2758-65. DMO8U3S RU https://pubmed.ncbi.nlm.nih.gov/18412318 DM1SOT4 DI DM1SOT4 DM1SOT4 DN [Gly8]GLP-1(7-37)-NH2 DM1SOT4 MI TTVIMDE DM1SOT4 MN Glucagon-like peptide 1 receptor (GLP1R) DM1SOT4 MT DTT DM1SOT4 MA Inhibitor DM1SOT4 RN Design and synthesis of conformationally constrained glucagon-like peptide-1 derivatives with increased plasma stability and prolonged in vivo acti... J Med Chem. 2008 May 8;51(9):2758-65. DM1SOT4 RU https://pubmed.ncbi.nlm.nih.gov/18412318 DMLZNK6 DI DMLZNK6 DMLZNK6 DN [HO1][Lys8(5/6C-Flu)]VT DMLZNK6 MI TTSCIUP DMLZNK6 MN Oxytocin receptor (OTR) DMLZNK6 MT DTT DMLZNK6 MA Inhibitor DMLZNK6 RN Synthesis and characterization of fluorescent antagonists and agonists for human oxytocin and vasopressin V(1)(a) receptors. J Med Chem. 2002 Jun 6;45(12):2579-88. DMLZNK6 RU https://pubmed.ncbi.nlm.nih.gov/12036367 DMLZNK6 DI DMLZNK6 DMLZNK6 DN [HO1][Lys8(5/6C-Flu)]VT DMLZNK6 MI TT4TFGN DMLZNK6 MN Vasopressin V1a receptor (V1AR) DMLZNK6 MT DTT DMLZNK6 MA Inhibitor DMLZNK6 RN Synthesis and characterization of fluorescent antagonists and agonists for human oxytocin and vasopressin V(1)(a) receptors. J Med Chem. 2002 Jun 6;45(12):2579-88. DMLZNK6 RU https://pubmed.ncbi.nlm.nih.gov/12036367 DMLZNK6 DI DMLZNK6 DMLZNK6 DN [HO1][Lys8(5/6C-Flu)]VT DMLZNK6 MI TTL9MHW DMLZNK6 MN Vasopressin V1b receptor (V1BR) DMLZNK6 MT DTT DMLZNK6 MA Inhibitor DMLZNK6 RN Synthesis and characterization of fluorescent antagonists and agonists for human oxytocin and vasopressin V(1)(a) receptors. J Med Chem. 2002 Jun 6;45(12):2579-88. DMLZNK6 RU https://pubmed.ncbi.nlm.nih.gov/12036367 DMFK9V5 DI DMFK9V5 DMFK9V5 DN [HO1][Orn8(5/6C-Flu)]VT DMFK9V5 MI TTSCIUP DMFK9V5 MN Oxytocin receptor (OTR) DMFK9V5 MT DTT DMFK9V5 MA Inhibitor DMFK9V5 RN Synthesis and characterization of fluorescent antagonists and agonists for human oxytocin and vasopressin V(1)(a) receptors. J Med Chem. 2002 Jun 6;45(12):2579-88. DMFK9V5 RU https://pubmed.ncbi.nlm.nih.gov/12036367 DMFK9V5 DI DMFK9V5 DMFK9V5 DN [HO1][Orn8(5/6C-Flu)]VT DMFK9V5 MI TT4TFGN DMFK9V5 MN Vasopressin V1a receptor (V1AR) DMFK9V5 MT DTT DMFK9V5 MA Inhibitor DMFK9V5 RN Synthesis and characterization of fluorescent antagonists and agonists for human oxytocin and vasopressin V(1)(a) receptors. J Med Chem. 2002 Jun 6;45(12):2579-88. DMFK9V5 RU https://pubmed.ncbi.nlm.nih.gov/12036367 DMFK9V5 DI DMFK9V5 DMFK9V5 DN [HO1][Orn8(5/6C-Flu)]VT DMFK9V5 MI TTL9MHW DMFK9V5 MN Vasopressin V1b receptor (V1BR) DMFK9V5 MT DTT DMFK9V5 MA Inhibitor DMFK9V5 RN Synthesis and characterization of fluorescent antagonists and agonists for human oxytocin and vasopressin V(1)(a) receptors. J Med Chem. 2002 Jun 6;45(12):2579-88. DMFK9V5 RU https://pubmed.ncbi.nlm.nih.gov/12036367 DM7COAM DI DM7COAM DM7COAM DN [HO1][Orn8(5/6C-Rhm)]VT DM7COAM MI TTSCIUP DM7COAM MN Oxytocin receptor (OTR) DM7COAM MT DTT DM7COAM MA Inhibitor DM7COAM RN Synthesis and characterization of fluorescent antagonists and agonists for human oxytocin and vasopressin V(1)(a) receptors. J Med Chem. 2002 Jun 6;45(12):2579-88. DM7COAM RU https://pubmed.ncbi.nlm.nih.gov/12036367 DM7COAM DI DM7COAM DM7COAM DN [HO1][Orn8(5/6C-Rhm)]VT DM7COAM MI TT4TFGN DM7COAM MN Vasopressin V1a receptor (V1AR) DM7COAM MT DTT DM7COAM MA Inhibitor DM7COAM RN Synthesis and characterization of fluorescent antagonists and agonists for human oxytocin and vasopressin V(1)(a) receptors. J Med Chem. 2002 Jun 6;45(12):2579-88. DM7COAM RU https://pubmed.ncbi.nlm.nih.gov/12036367 DMT2UYR DI DMT2UYR DMT2UYR DN [HO1][Thr4,Lys8(5/6C-Flu)]VT DMT2UYR MI TTSCIUP DMT2UYR MN Oxytocin receptor (OTR) DMT2UYR MT DTT DMT2UYR MA Inhibitor DMT2UYR RN Synthesis and characterization of fluorescent antagonists and agonists for human oxytocin and vasopressin V(1)(a) receptors. J Med Chem. 2002 Jun 6;45(12):2579-88. DMT2UYR RU https://pubmed.ncbi.nlm.nih.gov/12036367 DMT2UYR DI DMT2UYR DMT2UYR DN [HO1][Thr4,Lys8(5/6C-Flu)]VT DMT2UYR MI TT4TFGN DMT2UYR MN Vasopressin V1a receptor (V1AR) DMT2UYR MT DTT DMT2UYR MA Inhibitor DMT2UYR RN Synthesis and characterization of fluorescent antagonists and agonists for human oxytocin and vasopressin V(1)(a) receptors. J Med Chem. 2002 Jun 6;45(12):2579-88. DMT2UYR RU https://pubmed.ncbi.nlm.nih.gov/12036367 DMT2UYR DI DMT2UYR DMT2UYR DN [HO1][Thr4,Lys8(5/6C-Flu)]VT DMT2UYR MI TTL9MHW DMT2UYR MN Vasopressin V1b receptor (V1BR) DMT2UYR MT DTT DMT2UYR MA Inhibitor DMT2UYR RN Synthesis and characterization of fluorescent antagonists and agonists for human oxytocin and vasopressin V(1)(a) receptors. J Med Chem. 2002 Jun 6;45(12):2579-88. DMT2UYR RU https://pubmed.ncbi.nlm.nih.gov/12036367 DM81B4W DI DM81B4W DM81B4W DN [HO1][Thr4,Orn8(5/6C-Flu)]VT DM81B4W MI TTSCIUP DM81B4W MN Oxytocin receptor (OTR) DM81B4W MT DTT DM81B4W MA Inhibitor DM81B4W RN Synthesis and characterization of fluorescent antagonists and agonists for human oxytocin and vasopressin V(1)(a) receptors. J Med Chem. 2002 Jun 6;45(12):2579-88. DM81B4W RU https://pubmed.ncbi.nlm.nih.gov/12036367 DM81B4W DI DM81B4W DM81B4W DN [HO1][Thr4,Orn8(5/6C-Flu)]VT DM81B4W MI TT4TFGN DM81B4W MN Vasopressin V1a receptor (V1AR) DM81B4W MT DTT DM81B4W MA Inhibitor DM81B4W RN Synthesis and characterization of fluorescent antagonists and agonists for human oxytocin and vasopressin V(1)(a) receptors. J Med Chem. 2002 Jun 6;45(12):2579-88. DM81B4W RU https://pubmed.ncbi.nlm.nih.gov/12036367 DM81B4W DI DM81B4W DM81B4W DN [HO1][Thr4,Orn8(5/6C-Flu)]VT DM81B4W MI TTL9MHW DM81B4W MN Vasopressin V1b receptor (V1BR) DM81B4W MT DTT DM81B4W MA Inhibitor DM81B4W RN Synthesis and characterization of fluorescent antagonists and agonists for human oxytocin and vasopressin V(1)(a) receptors. J Med Chem. 2002 Jun 6;45(12):2579-88. DM81B4W RU https://pubmed.ncbi.nlm.nih.gov/12036367 DM7NXMB DI DM7NXMB DM7NXMB DN [HYDROXY(3-PHENYLPROPYL)AMINO]METHANOL DM7NXMB MI TTICO5G DM7NXMB MN Staphylococcus Peptide deformylase (Stap-coc def) DM7NXMB MT DTT DM7NXMB MA Inhibitor DM7NXMB RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DM7NXMB RU https://pubmed.ncbi.nlm.nih.gov/10592235 DMXTY6L DI DMXTY6L DMXTY6L DN [Leu13]motilin (human) DMXTY6L MI TT953CX DMXTY6L MN Motilin receptor (MLNR) DMXTY6L MT DTT DMXTY6L MA Agonist DMXTY6L RN Receptor for motilin identified in the human gastrointestinal system. Science. 1999 Jun 25;284(5423):2184-8. DMXTY6L RU https://pubmed.ncbi.nlm.nih.gov/10381885 DMA0N32 DI DMA0N32 DMA0N32 DN [Leu5]enkephalin DMA0N32 MI TT27RFC DMA0N32 MN Opioid receptor delta (OPRD1) DMA0N32 MT DTT DMA0N32 MA Inhibitor DMA0N32 RN Carba-analogues of fentanyl are opioid receptor agonists. J Med Chem. 2010 Apr 8;53(7):2875-81. DMA0N32 RU https://pubmed.ncbi.nlm.nih.gov/20218625 DMA0N32 DI DMA0N32 DMA0N32 DN [Leu5]enkephalin DMA0N32 MI TTQW87Y DMA0N32 MN Opioid receptor kappa (OPRK1) DMA0N32 MT DTT DMA0N32 MA Inhibitor DMA0N32 RN Carba-analogues of fentanyl are opioid receptor agonists. J Med Chem. 2010 Apr 8;53(7):2875-81. DMA0N32 RU https://pubmed.ncbi.nlm.nih.gov/20218625 DMA0N32 DI DMA0N32 DMA0N32 DN [Leu5]enkephalin DMA0N32 MI TTKWM86 DMA0N32 MN Opioid receptor mu (MOP) DMA0N32 MT DTT DMA0N32 MA Inhibitor DMA0N32 RN Carba-analogues of fentanyl are opioid receptor agonists. J Med Chem. 2010 Apr 8;53(7):2875-81. DMA0N32 RU https://pubmed.ncbi.nlm.nih.gov/20218625 DM3JHRC DI DM3JHRC DM3JHRC DN [Leu8,des-Arg9]bradykinin DM3JHRC MI TTGY8IW DM3JHRC MN B2 bradykinin receptor (BDKRB2) DM3JHRC MT DTT DM3JHRC MA Agonist DM3JHRC RN Partial agonists and full antagonists at the human and murine bradykinin B1 receptors. Can J Physiol Pharmacol. 1997 Jun;75(6):735-40. DM3JHRC RU https://pubmed.ncbi.nlm.nih.gov/9276157 DMHUMDR DI DMHUMDR DMHUMDR DN [L-Tic7]OT DMHUMDR MI TTSCIUP DMHUMDR MN Oxytocin receptor (OTR) DMHUMDR MT DTT DMHUMDR MA Inhibitor DMHUMDR RN Synthesis and biological activity of oxytocin analogues containing conformationally-restricted residues in position 7. Eur J Med Chem. 2007 Jun;42(6):799-806. DMHUMDR RU https://pubmed.ncbi.nlm.nih.gov/17316912 DM7STF6 DI DM7STF6 DM7STF6 DN [Lys8(Alexa 488) ]PVA DM7STF6 MI TTSCIUP DM7STF6 MN Oxytocin receptor (OTR) DM7STF6 MT DTT DM7STF6 MA Inhibitor DM7STF6 RN Toward efficient drug screening by homogeneous assays based on the development of new fluorescent vasopressin and oxytocin receptor ligands. J Med Chem. 2007 Oct 4;50(20):4976-85. DM7STF6 RU https://pubmed.ncbi.nlm.nih.gov/17850055 DM7STF6 DI DM7STF6 DM7STF6 DN [Lys8(Alexa 488) ]PVA DM7STF6 MI TT4TFGN DM7STF6 MN Vasopressin V1a receptor (V1AR) DM7STF6 MT DTT DM7STF6 MA Inhibitor DM7STF6 RN Toward efficient drug screening by homogeneous assays based on the development of new fluorescent vasopressin and oxytocin receptor ligands. J Med Chem. 2007 Oct 4;50(20):4976-85. DM7STF6 RU https://pubmed.ncbi.nlm.nih.gov/17850055 DM7STF6 DI DM7STF6 DM7STF6 DN [Lys8(Alexa 488) ]PVA DM7STF6 MI TTL9MHW DM7STF6 MN Vasopressin V1b receptor (V1BR) DM7STF6 MT DTT DM7STF6 MA Inhibitor DM7STF6 RN Toward efficient drug screening by homogeneous assays based on the development of new fluorescent vasopressin and oxytocin receptor ligands. J Med Chem. 2007 Oct 4;50(20):4976-85. DM7STF6 RU https://pubmed.ncbi.nlm.nih.gov/17850055 DM38L6U DI DM38L6U DM38L6U DN [Lys8(Alexa 546) ]PVA DM38L6U MI TTSCIUP DM38L6U MN Oxytocin receptor (OTR) DM38L6U MT DTT DM38L6U MA Inhibitor DM38L6U RN Toward efficient drug screening by homogeneous assays based on the development of new fluorescent vasopressin and oxytocin receptor ligands. J Med Chem. 2007 Oct 4;50(20):4976-85. DM38L6U RU https://pubmed.ncbi.nlm.nih.gov/17850055 DM38L6U DI DM38L6U DM38L6U DN [Lys8(Alexa 546) ]PVA DM38L6U MI TT4TFGN DM38L6U MN Vasopressin V1a receptor (V1AR) DM38L6U MT DTT DM38L6U MA Inhibitor DM38L6U RN Toward efficient drug screening by homogeneous assays based on the development of new fluorescent vasopressin and oxytocin receptor ligands. J Med Chem. 2007 Oct 4;50(20):4976-85. DM38L6U RU https://pubmed.ncbi.nlm.nih.gov/17850055 DM27LNU DI DM27LNU DM27LNU DN [Mpa1, D-Tic2, Aib7]OT DM27LNU MI TTSCIUP DM27LNU MN Oxytocin receptor (OTR) DM27LNU MT DTT DM27LNU MA Inhibitor DM27LNU RN Synthesis and biological activity of oxytocin analogues containing conformationally-restricted residues in position 7. Eur J Med Chem. 2007 Jun;42(6):799-806. DM27LNU RU https://pubmed.ncbi.nlm.nih.gov/17316912 DMPT1ME DI DMPT1ME DMPT1ME DN [Mpa1, D-Tic7]OT DMPT1ME MI TTSCIUP DMPT1ME MN Oxytocin receptor (OTR) DMPT1ME MT DTT DMPT1ME MA Inhibitor DMPT1ME RN Synthesis and biological activity of oxytocin analogues containing conformationally-restricted residues in position 7. Eur J Med Chem. 2007 Jun;42(6):799-806. DMPT1ME RU https://pubmed.ncbi.nlm.nih.gov/17316912 DMBPVSD DI DMBPVSD DMBPVSD DN [Mpa1, D-Tyr(Et)2, Aib7, D-Tic9]OT DMBPVSD MI TTSCIUP DMBPVSD MN Oxytocin receptor (OTR) DMBPVSD MT DTT DMBPVSD MA Inhibitor DMBPVSD RN Synthesis and biological activity of oxytocin analogues containing conformationally-restricted residues in position 7. Eur J Med Chem. 2007 Jun;42(6):799-806. DMBPVSD RU https://pubmed.ncbi.nlm.nih.gov/17316912 DMQSG6Y DI DMQSG6Y DMQSG6Y DN [Mpa1, D-Tyr(Et)2, Aib7]OT DMQSG6Y MI TTSCIUP DMQSG6Y MN Oxytocin receptor (OTR) DMQSG6Y MT DTT DMQSG6Y MA Inhibitor DMQSG6Y RN Synthesis and biological activity of oxytocin analogues containing conformationally-restricted residues in position 7. Eur J Med Chem. 2007 Jun;42(6):799-806. DMQSG6Y RU https://pubmed.ncbi.nlm.nih.gov/17316912 DM5GSXC DI DM5GSXC DM5GSXC DN [Mpa1, D-Tyr(Et)2, D-Tic7, Aib9]OT DM5GSXC MI TTSCIUP DM5GSXC MN Oxytocin receptor (OTR) DM5GSXC MT DTT DM5GSXC MA Inhibitor DM5GSXC RN Synthesis and biological activity of oxytocin analogues containing conformationally-restricted residues in position 7. Eur J Med Chem. 2007 Jun;42(6):799-806. DM5GSXC RU https://pubmed.ncbi.nlm.nih.gov/17316912 DMI9MBO DI DMI9MBO DMI9MBO DN [Mpa1, D-Tyr(Et)2, D-Tic7, D-Tic9]OT DMI9MBO MI TTSCIUP DMI9MBO MN Oxytocin receptor (OTR) DMI9MBO MT DTT DMI9MBO MA Inhibitor DMI9MBO RN Synthesis and biological activity of oxytocin analogues containing conformationally-restricted residues in position 7. Eur J Med Chem. 2007 Jun;42(6):799-806. DMI9MBO RU https://pubmed.ncbi.nlm.nih.gov/17316912 DM3T4JF DI DM3T4JF DM3T4JF DN [Mpa1, D-Tyr(Et)2, D-Tic7]OT DM3T4JF MI TTSCIUP DM3T4JF MN Oxytocin receptor (OTR) DM3T4JF MT DTT DM3T4JF MA Inhibitor DM3T4JF RN Synthesis and biological activity of oxytocin analogues containing conformationally-restricted residues in position 7. Eur J Med Chem. 2007 Jun;42(6):799-806. DM3T4JF RU https://pubmed.ncbi.nlm.nih.gov/17316912 DML8V4F DI DML8V4F DML8V4F DN [Mpa1, D-Tyr(Et)2, Gly(But)3, Gly(But)7]OT DML8V4F MI TTSCIUP DML8V4F MN Oxytocin receptor (OTR) DML8V4F MT DTT DML8V4F MA Inhibitor DML8V4F RN Synthesis and biological activity of oxytocin analogues containing conformationally-restricted residues in position 7. Eur J Med Chem. 2007 Jun;42(6):799-806. DML8V4F RU https://pubmed.ncbi.nlm.nih.gov/17316912 DMX2SU9 DI DMX2SU9 DMX2SU9 DN [Mpa1, D-Tyr(Et)2, Gly(But)7]OT DMX2SU9 MI TTSCIUP DMX2SU9 MN Oxytocin receptor (OTR) DMX2SU9 MT DTT DMX2SU9 MA Inhibitor DMX2SU9 RN Synthesis and biological activity of oxytocin analogues containing conformationally-restricted residues in position 7. Eur J Med Chem. 2007 Jun;42(6):799-806. DMX2SU9 RU https://pubmed.ncbi.nlm.nih.gov/17316912 DM0H3NV DI DM0H3NV DM0H3NV DN [Mpa1, D-Tyr(Et)2, L-Tic7]OT DM0H3NV MI TTSCIUP DM0H3NV MN Oxytocin receptor (OTR) DM0H3NV MT DTT DM0H3NV MA Inhibitor DM0H3NV RN Synthesis and biological activity of oxytocin analogues containing conformationally-restricted residues in position 7. Eur J Med Chem. 2007 Jun;42(6):799-806. DM0H3NV RU https://pubmed.ncbi.nlm.nih.gov/17316912 DM6W4LR DI DM6W4LR DM6W4LR DN [Mpa1, D-Tyr(Et)2, Pip7]OT DM6W4LR MI TTSCIUP DM6W4LR MN Oxytocin receptor (OTR) DM6W4LR MT DTT DM6W4LR MA Inhibitor DM6W4LR RN Synthesis and biological activity of oxytocin analogues containing conformationally-restricted residues in position 7. Eur J Med Chem. 2007 Jun;42(6):799-806. DM6W4LR RU https://pubmed.ncbi.nlm.nih.gov/17316912 DMB4J3N DI DMB4J3N DMB4J3N DN [Mpa1, L-Tic7]OT DMB4J3N MI TTSCIUP DMB4J3N MN Oxytocin receptor (OTR) DMB4J3N MT DTT DMB4J3N MA Inhibitor DMB4J3N RN Synthesis and biological activity of oxytocin analogues containing conformationally-restricted residues in position 7. Eur J Med Chem. 2007 Jun;42(6):799-806. DMB4J3N RU https://pubmed.ncbi.nlm.nih.gov/17316912 DMW9AST DI DMW9AST DMW9AST DN [N-[2-[(3'-N'-PROPYL-3''ALPHA-(BIS(4-FLUORORPHENYL)METHOXY)TROPANE-2''BETA-CARBOXYLIC ACID METHYL ESTER)(2-MERCAPTOETHYL)AMINO]ACETYL]-2-AMINOETHANETHIOLATO]RHENIUM(V) OXIDE (DIASTEREOMERIC MIX) DMW9AST MI TTVBI8W DMW9AST MN Dopamine transporter (DAT) DMW9AST MT DTT DMW9AST MA Inhibitor DMW9AST RN A technetium-99m SPECT imaging agent which targets the dopamine transporter in primate brain. J Med Chem. 1997 Jun 6;40(12):1835-44. DMW9AST RU https://pubmed.ncbi.nlm.nih.gov/9191960 DM6EAHF DI DM6EAHF DM6EAHF DN [N40,Pro1,Tyr4,Nle 14]BB DM6EAHF MI TTC1MVT DM6EAHF MN Gastrin-releasing peptide receptor (GRPR) DM6EAHF MT DTT DM6EAHF MA Inhibitor DM6EAHF RN Potent bombesin-like peptides for GRP-receptor targeting of tumors with 99mTc: a preclinical study. J Med Chem. 2005 Jan 13;48(1):100-10. DM6EAHF RU https://pubmed.ncbi.nlm.nih.gov/15634004 DMVFHNM DI DMVFHNM DMVFHNM DN [N40,Pro1,Tyr4]BB DMVFHNM MI TTC1MVT DMVFHNM MN Gastrin-releasing peptide receptor (GRPR) DMVFHNM MT DTT DMVFHNM MA Inhibitor DMVFHNM RN Potent bombesin-like peptides for GRP-receptor targeting of tumors with 99mTc: a preclinical study. J Med Chem. 2005 Jan 13;48(1):100-10. DMVFHNM RU https://pubmed.ncbi.nlm.nih.gov/15634004 DMW6LIJ DI DMW6LIJ DMW6LIJ DN [N-Ac,des-Sar]Gal-B2 DMW6LIJ MI TTX3HNZ DMW6LIJ MN Galanin receptor type 1 (GAL1-R) DMW6LIJ MT DTT DMW6LIJ MA Inhibitor DMW6LIJ RN Engineering galanin analogues that discriminate between GalR1 and GalR2 receptor subtypes and exhibit anticonvulsant activity following systemic de... J Med Chem. 2010 Feb 25;53(4):1871-5. DMW6LIJ RU https://pubmed.ncbi.nlm.nih.gov/20121116 DMW6LIJ DI DMW6LIJ DMW6LIJ DN [N-Ac,des-Sar]Gal-B2 DMW6LIJ MI TTBPW3J DMW6LIJ MN Galanin receptor type 2 (GAL2-R) DMW6LIJ MT DTT DMW6LIJ MA Inhibitor DMW6LIJ RN Engineering galanin analogues that discriminate between GalR1 and GalR2 receptor subtypes and exhibit anticonvulsant activity following systemic de... J Med Chem. 2010 Feb 25;53(4):1871-5. DMW6LIJ RU https://pubmed.ncbi.nlm.nih.gov/20121116 DME6LKY DI DME6LKY DME6LKY DN [Ncy(2-naphthyl)1]acyline DME6LKY MI TT8R70G DME6LKY MN Gonadotropin-releasing hormone receptor (GNRHR) DME6LKY MT DTT DME6LKY MA Inhibitor DME6LKY RN Structure-activity relationship studies of gonadotropin-releasing hormone antagonists containing S-aryl/alkyl norcysteines and their oxidized deriv... J Med Chem. 2007 May 3;50(9):2067-77. DME6LKY RU https://pubmed.ncbi.nlm.nih.gov/17402723 DM5CS8U DI DM5CS8U DM5CS8U DN [Ncy(isopropyl)7]acyline DM5CS8U MI TT8R70G DM5CS8U MN Gonadotropin-releasing hormone receptor (GNRHR) DM5CS8U MT DTT DM5CS8U MA Inhibitor DM5CS8U RN Structure-activity relationship studies of gonadotropin-releasing hormone antagonists containing S-aryl/alkyl norcysteines and their oxidized deriv... J Med Chem. 2007 May 3;50(9):2067-77. DM5CS8U RU https://pubmed.ncbi.nlm.nih.gov/17402723 DM9RC3O DI DM9RC3O DM9RC3O DN [Ncy(methyl)10]acyline DM9RC3O MI TT8R70G DM9RC3O MN Gonadotropin-releasing hormone receptor (GNRHR) DM9RC3O MT DTT DM9RC3O MA Inhibitor DM9RC3O RN Structure-activity relationship studies of gonadotropin-releasing hormone antagonists containing S-aryl/alkyl norcysteines and their oxidized deriv... J Med Chem. 2007 May 3;50(9):2067-77. DM9RC3O RU https://pubmed.ncbi.nlm.nih.gov/17402723 DMLK8YQ DI DMLK8YQ DMLK8YQ DN [Ncy(methyl)4]acyline DMLK8YQ MI TT8R70G DMLK8YQ MN Gonadotropin-releasing hormone receptor (GNRHR) DMLK8YQ MT DTT DMLK8YQ MA Inhibitor DMLK8YQ RN Structure-activity relationship studies of gonadotropin-releasing hormone antagonists containing S-aryl/alkyl norcysteines and their oxidized deriv... J Med Chem. 2007 May 3;50(9):2067-77. DMLK8YQ RU https://pubmed.ncbi.nlm.nih.gov/17402723 DMEFIQ9 DI DMEFIQ9 DMEFIQ9 DN [Ncy(SO,isopropyl)7]acyline DMEFIQ9 MI TT8R70G DMEFIQ9 MN Gonadotropin-releasing hormone receptor (GNRHR) DMEFIQ9 MT DTT DMEFIQ9 MA Inhibitor DMEFIQ9 RN Structure-activity relationship studies of gonadotropin-releasing hormone antagonists containing S-aryl/alkyl norcysteines and their oxidized deriv... J Med Chem. 2007 May 3;50(9):2067-77. DMEFIQ9 RU https://pubmed.ncbi.nlm.nih.gov/17402723 DMT8X45 DI DMT8X45 DMT8X45 DN [Ncy(SO,methyl)10]acyline DMT8X45 MI TT8R70G DMT8X45 MN Gonadotropin-releasing hormone receptor (GNRHR) DMT8X45 MT DTT DMT8X45 MA Inhibitor DMT8X45 RN Structure-activity relationship studies of gonadotropin-releasing hormone antagonists containing S-aryl/alkyl norcysteines and their oxidized deriv... J Med Chem. 2007 May 3;50(9):2067-77. DMT8X45 RU https://pubmed.ncbi.nlm.nih.gov/17402723 DM057MP DI DM057MP DM057MP DN [Ncy(SO,methyl)4]acyline DM057MP MI TT8R70G DM057MP MN Gonadotropin-releasing hormone receptor (GNRHR) DM057MP MT DTT DM057MP MA Inhibitor DM057MP RN Structure-activity relationship studies of gonadotropin-releasing hormone antagonists containing S-aryl/alkyl norcysteines and their oxidized deriv... J Med Chem. 2007 May 3;50(9):2067-77. DM057MP RU https://pubmed.ncbi.nlm.nih.gov/17402723 DM4XFOH DI DM4XFOH DM4XFOH DN [N-Me,des-Sar]Gal-B2 DM4XFOH MI TTX3HNZ DM4XFOH MN Galanin receptor type 1 (GAL1-R) DM4XFOH MT DTT DM4XFOH MA Inhibitor DM4XFOH RN Engineering galanin analogues that discriminate between GalR1 and GalR2 receptor subtypes and exhibit anticonvulsant activity following systemic de... J Med Chem. 2010 Feb 25;53(4):1871-5. DM4XFOH RU https://pubmed.ncbi.nlm.nih.gov/20121116 DM4XFOH DI DM4XFOH DM4XFOH DN [N-Me,des-Sar]Gal-B2 DM4XFOH MI TTBPW3J DM4XFOH MN Galanin receptor type 2 (GAL2-R) DM4XFOH MT DTT DM4XFOH MA Inhibitor DM4XFOH RN Engineering galanin analogues that discriminate between GalR1 and GalR2 receptor subtypes and exhibit anticonvulsant activity following systemic de... J Med Chem. 2010 Feb 25;53(4):1871-5. DM4XFOH RU https://pubmed.ncbi.nlm.nih.gov/20121116 DMTG17Q DI DMTG17Q DMTG17Q DN [Nphe(1)]-nociceptin (1-13)-NH(2) DMTG17Q MI TTNT7K8 DMTG17Q MN Nociceptin receptor (OPRL1) DMTG17Q MT DTT DMTG17Q MA Antagonist DMTG17Q RN Nociceptin receptor antagonists display antidepressant-like properties in the mouse forced swimming test. Naunyn Schmiedebergs Arch Pharmacol. 2002 Feb;365(2):164-7. DMTG17Q RU https://pubmed.ncbi.nlm.nih.gov/11819035 DMK18CS DI DMK18CS DMK18CS DN [Phe3]OT DMK18CS MI TTSCIUP DMK18CS MN Oxytocin receptor (OTR) DMK18CS MT DTT DMK18CS MA Agonist DMK18CS RN Two aromatic residues regulate the response of the human oxytocin receptor to the partial agonist arginine vasopressin. FEBS Lett. 1996 Nov 18;397(2-3):201-6. DMK18CS RU https://pubmed.ncbi.nlm.nih.gov/8955347 DMK18CS DI DMK18CS DMK18CS DN [Phe3]OT DMK18CS MI TT4TFGN DMK18CS MN Vasopressin V1a receptor (V1AR) DMK18CS MT DTT DMK18CS MA Agonist DMK18CS RN Tyr115 is the key residue for determining agonist selectivity in the V1a vasopressin receptor. EMBO J. 1995 May 15;14(10):2176-82. DMK18CS RU https://pubmed.ncbi.nlm.nih.gov/7774575 DMK18CS DI DMK18CS DMK18CS DN [Phe3]OT DMK18CS MI TTK8R02 DMK18CS MN Vasopressin V2 receptor (V2R) DMK18CS MT DTT DMK18CS MA Agonist DMK18CS RN Tyr115 is the key residue for determining agonist selectivity in the V1a vasopressin receptor. EMBO J. 1995 May 15;14(10):2176-82. DMK18CS RU https://pubmed.ncbi.nlm.nih.gov/7774575 DMXJDEA DI DMXJDEA DMXJDEA DN [Pip7]OT DMXJDEA MI TTSCIUP DMXJDEA MN Oxytocin receptor (OTR) DMXJDEA MT DTT DMXJDEA MA Inhibitor DMXJDEA RN Synthesis and biological activity of oxytocin analogues containing conformationally-restricted residues in position 7. Eur J Med Chem. 2007 Jun;42(6):799-806. DMXJDEA RU https://pubmed.ncbi.nlm.nih.gov/17316912 DM4ZY79 DI DM4ZY79 DM4ZY79 DN [Pterin-6-Yl Methanyl]-Phosphonophosphate DM4ZY79 MI TT4ILYC DM4ZY79 MN Bacterial Dihydropteroate synthetase (Bact folP) DM4ZY79 MT DTT DM4ZY79 MA Inhibitor DM4ZY79 RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DM4ZY79 RU https://pubmed.ncbi.nlm.nih.gov/17139284 DM4ZY79 DI DM4ZY79 DM4ZY79 DN [Pterin-6-Yl Methanyl]-Phosphonophosphate DM4ZY79 MI TT38ECI DM4ZY79 MN Bacterial Hydroxymethyl-dihydropterin pyrophosphokinase (Bact folK) DM4ZY79 MT DTT DM4ZY79 MA Inhibitor DM4ZY79 RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DM4ZY79 RU https://pubmed.ncbi.nlm.nih.gov/17139284 DM8YF3V DI DM8YF3V DM8YF3V DN [R-(-)-Apomorphine-2-yl]-(2'-hydroxy-ethyl)ether DM8YF3V MI TTZFYLI DM8YF3V MN Dopamine D1 receptor (D1R) DM8YF3V MT DTT DM8YF3V MA Inhibitor DM8YF3V RN Synthesis and neuropharmacological characterization of 2-O-substituted apomorphines. Bioorg Med Chem. 2008 Apr 15;16(8):4563-8. DM8YF3V RU https://pubmed.ncbi.nlm.nih.gov/18313931 DM8YF3V DI DM8YF3V DM8YF3V DN [R-(-)-Apomorphine-2-yl]-(2'-hydroxy-ethyl)ether DM8YF3V MI TTEX248 DM8YF3V MN Dopamine D2 receptor (D2R) DM8YF3V MT DTT DM8YF3V MA Inhibitor DM8YF3V RN Synthesis and neuropharmacological characterization of 2-O-substituted apomorphines. Bioorg Med Chem. 2008 Apr 15;16(8):4563-8. DM8YF3V RU https://pubmed.ncbi.nlm.nih.gov/18313931 DMUF7DP DI DMUF7DP DMUF7DP DN [Sar,D-Phe8,des-Arg9]bradykinin DMUF7DP MI TTGY8IW DMUF7DP MN B2 bradykinin receptor (BDKRB2) DMUF7DP MT DTT DMUF7DP MA Agonist DMUF7DP RN Molecular characterisation of cloned bradykinin B1 receptors from rat and human. Eur J Pharmacol. 1999 Jun 25;374(3):423-33. DMUF7DP RU https://pubmed.ncbi.nlm.nih.gov/10422787 DM1HQ3D DI DM1HQ3D DM1HQ3D DN [Sar1,Bpa2]AngII DM1HQ3D MI TT8DBY3 DM1HQ3D MN Angiotensin II receptor type-1 (AGTR1) DM1HQ3D MT DTT DM1HQ3D MA Inhibitor DM1HQ3D RN The amino-terminus of angiotensin II contacts several ectodomains of the angiotensin II receptor AT1. J Med Chem. 2010 Mar 11;53(5):2063-75. DM1HQ3D RU https://pubmed.ncbi.nlm.nih.gov/20146480 DMP64XH DI DMP64XH DMP64XH DN [Sar1,Bpa3]AngII DMP64XH MI TT8DBY3 DMP64XH MN Angiotensin II receptor type-1 (AGTR1) DMP64XH MT DTT DMP64XH MA Inhibitor DMP64XH RN The amino-terminus of angiotensin II contacts several ectodomains of the angiotensin II receptor AT1. J Med Chem. 2010 Mar 11;53(5):2063-75. DMP64XH RU https://pubmed.ncbi.nlm.nih.gov/20146480 DMWC10R DI DMWC10R DMWC10R DN [Sar1,Bpa8]AngII DMWC10R MI TT8DBY3 DMWC10R MN Angiotensin II receptor type-1 (AGTR1) DMWC10R MT DTT DMWC10R MA Inhibitor DMWC10R RN The amino-terminus of angiotensin II contacts several ectodomains of the angiotensin II receptor AT1. J Med Chem. 2010 Mar 11;53(5):2063-75. DMWC10R RU https://pubmed.ncbi.nlm.nih.gov/20146480 DM4AUFR DI DM4AUFR DM4AUFR DN [Sar1,Tdf2]AngII DM4AUFR MI TT8DBY3 DM4AUFR MN Angiotensin II receptor type-1 (AGTR1) DM4AUFR MT DTT DM4AUFR MA Inhibitor DM4AUFR RN The amino-terminus of angiotensin II contacts several ectodomains of the angiotensin II receptor AT1. J Med Chem. 2010 Mar 11;53(5):2063-75. DM4AUFR RU https://pubmed.ncbi.nlm.nih.gov/20146480 DMWCS4Y DI DMWCS4Y DMWCS4Y DN [Sar1,Tdf3]AngII DMWCS4Y MI TT8DBY3 DMWCS4Y MN Angiotensin II receptor type-1 (AGTR1) DMWCS4Y MT DTT DMWCS4Y MA Inhibitor DMWCS4Y RN The amino-terminus of angiotensin II contacts several ectodomains of the angiotensin II receptor AT1. J Med Chem. 2010 Mar 11;53(5):2063-75. DMWCS4Y RU https://pubmed.ncbi.nlm.nih.gov/20146480 DMTNGCW DI DMTNGCW DMTNGCW DN [Sar1,Tdf8]AngII DMTNGCW MI TT8DBY3 DMTNGCW MN Angiotensin II receptor type-1 (AGTR1) DMTNGCW MT DTT DMTNGCW MA Inhibitor DMTNGCW RN The amino-terminus of angiotensin II contacts several ectodomains of the angiotensin II receptor AT1. J Med Chem. 2010 Mar 11;53(5):2063-75. DMTNGCW RU https://pubmed.ncbi.nlm.nih.gov/20146480 DMUD0LA DI DMUD0LA DMUD0LA DN [Sar1Ala]GAL-B2 DMUD0LA MI TTX3HNZ DMUD0LA MN Galanin receptor type 1 (GAL1-R) DMUD0LA MT DTT DMUD0LA MA Inhibitor DMUD0LA RN Engineering galanin analogues that discriminate between GalR1 and GalR2 receptor subtypes and exhibit anticonvulsant activity following systemic de... J Med Chem. 2010 Feb 25;53(4):1871-5. DMUD0LA RU https://pubmed.ncbi.nlm.nih.gov/20121116 DMUD0LA DI DMUD0LA DMUD0LA DN [Sar1Ala]GAL-B2 DMUD0LA MI TTBPW3J DMUD0LA MN Galanin receptor type 2 (GAL2-R) DMUD0LA MT DTT DMUD0LA MA Inhibitor DMUD0LA RN Engineering galanin analogues that discriminate between GalR1 and GalR2 receptor subtypes and exhibit anticonvulsant activity following systemic de... J Med Chem. 2010 Feb 25;53(4):1871-5. DMUD0LA RU https://pubmed.ncbi.nlm.nih.gov/20121116 DMUI0XV DI DMUI0XV DMUI0XV DN [Sar1Gly]GAL-B2 DMUI0XV MI TTX3HNZ DMUI0XV MN Galanin receptor type 1 (GAL1-R) DMUI0XV MT DTT DMUI0XV MA Inhibitor DMUI0XV RN Engineering galanin analogues that discriminate between GalR1 and GalR2 receptor subtypes and exhibit anticonvulsant activity following systemic de... J Med Chem. 2010 Feb 25;53(4):1871-5. DMUI0XV RU https://pubmed.ncbi.nlm.nih.gov/20121116 DMUI0XV DI DMUI0XV DMUI0XV DN [Sar1Gly]GAL-B2 DMUI0XV MI TTBPW3J DMUI0XV MN Galanin receptor type 2 (GAL2-R) DMUI0XV MT DTT DMUI0XV MA Inhibitor DMUI0XV RN Engineering galanin analogues that discriminate between GalR1 and GalR2 receptor subtypes and exhibit anticonvulsant activity following systemic de... J Med Chem. 2010 Feb 25;53(4):1871-5. DMUI0XV RU https://pubmed.ncbi.nlm.nih.gov/20121116 DMYF85Q DI DMYF85Q DMYF85Q DN [Sar9,Met(O2)11]-SP DMYF85Q MI TTZPO1L DMYF85Q MN Substance-P receptor (TACR1) DMYF85Q MT DTT DMYF85Q MA Inhibitor DMYF85Q RN cis-4-(Piperazin-1-yl)-5,6,7a,8,9,10,11,11a-octahydrobenzofuro[2,3-h]quinazolin-2-amine (A-987306), a new histamine H4R antagonist that blocks pain... J Med Chem. 2008 Nov 27;51(22):7094-8. DMYF85Q RU https://pubmed.ncbi.nlm.nih.gov/18983139 DMN0BT3 DI DMN0BT3 DMN0BT3 DN [Tdf1]AngII DMN0BT3 MI TT8DBY3 DMN0BT3 MN Angiotensin II receptor type-1 (AGTR1) DMN0BT3 MT DTT DMN0BT3 MA Inhibitor DMN0BT3 RN The amino-terminus of angiotensin II contacts several ectodomains of the angiotensin II receptor AT1. J Med Chem. 2010 Mar 11;53(5):2063-75. DMN0BT3 RU https://pubmed.ncbi.nlm.nih.gov/20146480 DM7QAKB DI DM7QAKB DM7QAKB DN [Thr4,Gly7]OT DM7QAKB MI TTSCIUP DM7QAKB MN Oxytocin receptor (OTR) DM7QAKB MT DTT DM7QAKB MA Agonist DM7QAKB RN [3H]-[Thr4,Gly7]OT: a highly selective ligand for central and peripheral OT receptors. Am J Physiol. 1988 Jan;254(1 Pt 1):E31-8. DM7QAKB RU https://pubmed.ncbi.nlm.nih.gov/2827511 DM7QAKB DI DM7QAKB DM7QAKB DN [Thr4,Gly7]OT DM7QAKB MI TT4TFGN DM7QAKB MN Vasopressin V1a receptor (V1AR) DM7QAKB MT DTT DM7QAKB MA Agonist DM7QAKB RN Mapping peptide-binding domains of the human V1a vasopressin receptor with a photoactivatable linear peptide antagonist. J Biol Chem. 1997 Oct 17;272(42):26536-44. DM7QAKB RU https://pubmed.ncbi.nlm.nih.gov/9334232 DMA6VNI DI DMA6VNI DMA6VNI DN [Tyr4]Bombesin DMA6VNI MI TTC1MVT DMA6VNI MN Gastrin-releasing peptide receptor (GRPR) DMA6VNI MT DTT DMA6VNI MA Inhibitor DMA6VNI RN Potent bombesin-like peptides for GRP-receptor targeting of tumors with 99mTc: a preclinical study. J Med Chem. 2005 Jan 13;48(1):100-10. DMA6VNI RU https://pubmed.ncbi.nlm.nih.gov/15634004 DM61RG2 DI DM61RG2 DM61RG2 DN [Tyr-Pro-Phe-NH-]2 DM61RG2 MI TTKWM86 DM61RG2 MN Opioid receptor mu (MOP) DM61RG2 MT DTT DM61RG2 MA Inhibitor DM61RG2 RN Structure-activity relationship of the novel bivalent and C-terminal modified analogues of endomorphin-2. Bioorg Med Chem Lett. 2005 Apr 1;15(7):1847-50. DM61RG2 RU https://pubmed.ncbi.nlm.nih.gov/15780619 DMZTRQ0 DI DMZTRQ0 DMZTRQ0 DN [Tyr-Pro-Phe-NH-CH2-]2 DMZTRQ0 MI TTKWM86 DMZTRQ0 MN Opioid receptor mu (MOP) DMZTRQ0 MT DTT DMZTRQ0 MA Inhibitor DMZTRQ0 RN Structure-activity relationship of the novel bivalent and C-terminal modified analogues of endomorphin-2. Bioorg Med Chem Lett. 2005 Apr 1;15(7):1847-50. DMZTRQ0 RU https://pubmed.ncbi.nlm.nih.gov/15780619 DME6TNL DI DME6TNL DME6TNL DN [Tyr-Pro-Phe-Phe-NH-]2 DME6TNL MI TTKWM86 DME6TNL MN Opioid receptor mu (MOP) DME6TNL MT DTT DME6TNL MA Inhibitor DME6TNL RN Structure-activity relationship of the novel bivalent and C-terminal modified analogues of endomorphin-2. Bioorg Med Chem Lett. 2005 Apr 1;15(7):1847-50. DME6TNL RU https://pubmed.ncbi.nlm.nih.gov/15780619 DMFGO4W DI DMFGO4W DMFGO4W DN [Tyr-Pro-Phe-Phe-NH-CH2-]2 DMFGO4W MI TTKWM86 DMFGO4W MN Opioid receptor mu (MOP) DMFGO4W MT DTT DMFGO4W MA Inhibitor DMFGO4W RN Structure-activity relationship of the novel bivalent and C-terminal modified analogues of endomorphin-2. Bioorg Med Chem Lett. 2005 Apr 1;15(7):1847-50. DMFGO4W RU https://pubmed.ncbi.nlm.nih.gov/15780619 DMP3I6E DI DMP3I6E DMP3I6E DN [U-13C]ascomycin DMP3I6E MI TTQW87Y DMP3I6E MN Opioid receptor kappa (OPRK1) DMP3I6E MT DTT DMP3I6E MA Antagonist DMP3I6E RN NMR studies of an FK-506 analog, [U-13C]ascomycin, bound to FK-506-binding protein. J Med Chem. 1992 Jun 26;35(13):2467-73. DMP3I6E RU https://pubmed.ncbi.nlm.nih.gov/1377749 DMW82ZT DI DMW82ZT DMW82ZT DN [Val4]AVP DMW82ZT MI TT4TFGN DMW82ZT MN Vasopressin V1a receptor (V1AR) DMW82ZT MT DTT DMW82ZT MA Agonist DMW82ZT RN [1-deamino-4-cyclohexylalanine] arginine vasopressin: a potent and specific agonist for vasopressin V1b receptors. Endocrinology. 2002 Dec;143(12):4655-64. DMW82ZT RU https://pubmed.ncbi.nlm.nih.gov/12446593 DMW82ZT DI DMW82ZT DMW82ZT DN [Val4]AVP DMW82ZT MI TTL9MHW DMW82ZT MN Vasopressin V1b receptor (V1BR) DMW82ZT MT DTT DMW82ZT MA Agonist DMW82ZT RN [1-deamino-4-cyclohexylalanine] arginine vasopressin: a potent and specific agonist for vasopressin V1b receptors. Endocrinology. 2002 Dec;143(12):4655-64. DMW82ZT RU https://pubmed.ncbi.nlm.nih.gov/12446593 DMW82ZT DI DMW82ZT DMW82ZT DN [Val4]AVP DMW82ZT MI TTK8R02 DMW82ZT MN Vasopressin V2 receptor (V2R) DMW82ZT MT DTT DMW82ZT MA Agonist DMW82ZT RN [1-deamino-4-cyclohexylalanine] arginine vasopressin: a potent and specific agonist for vasopressin V1b receptors. Endocrinology. 2002 Dec;143(12):4655-64. DMW82ZT RU https://pubmed.ncbi.nlm.nih.gov/12446593 DMMB4US DI DMMB4US DMMB4US DN {[(9Z)-octadec-9-en-1-yl]sulfamoyl}amine DMMB4US MI TT6OEDT DMMB4US MN Cannabinoid receptor 1 (CB1) DMMB4US MT DTT DMMB4US MA Inhibitor DMMB4US RN Synthesis and pharmacological evaluation of sulfamide-based analogues of anandamide. Eur J Med Chem. 2009 Dec;44(12):4889-95. DMMB4US RU https://pubmed.ncbi.nlm.nih.gov/19762126 DM3FBAZ DI DM3FBAZ DM3FBAZ DN {2-[3-(Phenylsulfonyl)-1H-indol-4-yl]ethyl}amine DM3FBAZ MI TTAWNKZ DM3FBAZ MN Norepinephrine transporter (NET) DM3FBAZ MT DTT DM3FBAZ MA Inhibitor DM3FBAZ RN Dual acting norepinephrine reuptake inhibitors and 5-HT(2A) receptor antagonists: Identification, synthesis and activity of novel 4-aminoethyl-3-(p... Bioorg Med Chem. 2009 Nov 15;17(22):7802-15. DM3FBAZ RU https://pubmed.ncbi.nlm.nih.gov/19836247 DMX53OY DI DMX53OY DMX53OY DN {4-[4-(4-bromophenoxy)benzoyl]phenyl}acetic acid DMX53OY MI TTTU72V DMX53OY MN Steroid 5-alpha-reductase 1 (SRD5A1) DMX53OY MT DTT DMX53OY MA Inhibitor DMX53OY RN Novel 5alpha-reductase inhibitors: synthesis, structure-activity studies, and pharmacokinetic profile of phenoxybenzoylphenyl acetic acids. J Med Chem. 2006 Jan 26;49(2):748-59. DMX53OY RU https://pubmed.ncbi.nlm.nih.gov/16420060 DMX53OY DI DMX53OY DMX53OY DN {4-[4-(4-bromophenoxy)benzoyl]phenyl}acetic acid DMX53OY MI TTT02K8 DMX53OY MN Steroid 5-alpha-reductase 2 (SRD5A2) DMX53OY MT DTT DMX53OY MA Inhibitor DMX53OY RN Novel 5alpha-reductase inhibitors: synthesis, structure-activity studies, and pharmacokinetic profile of phenoxybenzoylphenyl acetic acids. J Med Chem. 2006 Jan 26;49(2):748-59. DMX53OY RU https://pubmed.ncbi.nlm.nih.gov/16420060 DMQEJVU DI DMQEJVU DMQEJVU DN 1-((2-chlorophenyl)diphenylmethyl)-1H-pyrazole DMQEJVU MI TTMNI76 DMQEJVU MN Calcium-activated potassium channel (KCN) DMQEJVU MT DTT DMQEJVU MA Inhibitor DMQEJVU RN Inhibitors of potassium channels KV1.3 and IK-1 as immunosuppressants. Bioorg Med Chem Lett. 2009 Apr 15;19(8):2299-304. DMQEJVU RU https://pubmed.ncbi.nlm.nih.gov/19282171 DMQEJVU DI DMQEJVU DMQEJVU DN 1-((2-chlorophenyl)diphenylmethyl)-1H-pyrazole DMQEJVU MI TT7M9I6 DMQEJVU MN Calcium-activated potassium channel KCa3.1 (KCNN4) DMQEJVU MT DTT DMQEJVU MA Blocker (channel blocker) DMQEJVU RN Blockade of the intermediate-conductance calcium-activated potassium channel as a new therapeutic strategy for restenosis. Circulation. 2003 Sep 2;108(9):1119-25. DMQEJVU RU https://pubmed.ncbi.nlm.nih.gov/12939222 DMGRV8U DI DMGRV8U DMGRV8U DN 1-((9H-Fluoren-2-yl)ethyl)-1H-imidazole DMGRV8U MI TTRA5BZ DMGRV8U MN Steroid 17-alpha-monooxygenase (S17AH) DMGRV8U MT DTT DMGRV8U MA Inhibitor DMGRV8U RN Synthesis, biological evaluation, and molecular modeling studies of methylene imidazole substituted biaryls as inhibitors of human 17alpha-hydroxyl... Bioorg Med Chem. 2008 Aug 15;16(16):7715-27. DMGRV8U RU https://pubmed.ncbi.nlm.nih.gov/18674917 DMPBJ9L DI DMPBJ9L DMPBJ9L DN 1-((9H-Fluoren-2-yl)methyl)-1H-imidazole DMPBJ9L MI TTRA5BZ DMPBJ9L MN Steroid 17-alpha-monooxygenase (S17AH) DMPBJ9L MT DTT DMPBJ9L MA Inhibitor DMPBJ9L RN Synthesis, biological evaluation, and molecular modeling studies of methylene imidazole substituted biaryls as inhibitors of human 17alpha-hydroxyl... Bioorg Med Chem. 2008 Aug 15;16(16):7715-27. DMPBJ9L RU https://pubmed.ncbi.nlm.nih.gov/18674917 DM74R0E DI DM74R0E DM74R0E DN 1-((R)-2-aminopropyl)-1H-indazol-6-ol DM74R0E MI TTJQOD7 DM74R0E MN 5-HT 2A receptor (HTR2A) DM74R0E MT DTT DM74R0E MA Inhibitor DM74R0E RN 1-((S)-2-aminopropyl)-1H-indazol-6-ol: a potent peripherally acting 5-HT2 receptor agonist with ocular hypotensive activity. J Med Chem. 2006 Jan 12;49(1):318-28. DM74R0E RU https://pubmed.ncbi.nlm.nih.gov/16392816 DM74R0E DI DM74R0E DM74R0E DN 1-((R)-2-aminopropyl)-1H-indazol-6-ol DM74R0E MI TT0K1SC DM74R0E MN 5-HT 2B receptor (HTR2B) DM74R0E MT DTT DM74R0E MA Inhibitor DM74R0E RN 1-((S)-2-aminopropyl)-1H-indazol-6-ol: a potent peripherally acting 5-HT2 receptor agonist with ocular hypotensive activity. J Med Chem. 2006 Jan 12;49(1):318-28. DM74R0E RU https://pubmed.ncbi.nlm.nih.gov/16392816 DM74R0E DI DM74R0E DM74R0E DN 1-((R)-2-aminopropyl)-1H-indazol-6-ol DM74R0E MI TTWJBZ5 DM74R0E MN 5-HT 2C receptor (HTR2C) DM74R0E MT DTT DM74R0E MA Inhibitor DM74R0E RN 1-((S)-2-aminopropyl)-1H-indazol-6-ol: a potent peripherally acting 5-HT2 receptor agonist with ocular hypotensive activity. J Med Chem. 2006 Jan 12;49(1):318-28. DM74R0E RU https://pubmed.ncbi.nlm.nih.gov/16392816 DMU83KP DI DMU83KP DMU83KP DN 1-((S)-2-aminopropyl)-1H-indazol-6-ol DMU83KP MI TTSQIFT DMU83KP MN 5-HT 1A receptor (HTR1A) DMU83KP MT DTT DMU83KP MA Inhibitor DMU83KP RN 1-((S)-2-aminopropyl)-1H-indazol-6-ol: a potent peripherally acting 5-HT2 receptor agonist with ocular hypotensive activity. J Med Chem. 2006 Jan 12;49(1):318-28. DMU83KP RU https://pubmed.ncbi.nlm.nih.gov/16392816 DMU83KP DI DMU83KP DMU83KP DN 1-((S)-2-aminopropyl)-1H-indazol-6-ol DMU83KP MI TT6MSOK DMU83KP MN 5-HT 1D receptor (HTR1D) DMU83KP MT DTT DMU83KP MA Inhibitor DMU83KP RN 1-((S)-2-aminopropyl)-1H-indazol-6-ol: a potent peripherally acting 5-HT2 receptor agonist with ocular hypotensive activity. J Med Chem. 2006 Jan 12;49(1):318-28. DMU83KP RU https://pubmed.ncbi.nlm.nih.gov/16392816 DMU83KP DI DMU83KP DMU83KP DN 1-((S)-2-aminopropyl)-1H-indazol-6-ol DMU83KP MI TTJQOD7 DMU83KP MN 5-HT 2A receptor (HTR2A) DMU83KP MT DTT DMU83KP MA Inhibitor DMU83KP RN 1-((S)-2-aminopropyl)-1H-indazol-6-ol: a potent peripherally acting 5-HT2 receptor agonist with ocular hypotensive activity. J Med Chem. 2006 Jan 12;49(1):318-28. DMU83KP RU https://pubmed.ncbi.nlm.nih.gov/16392816 DMU83KP DI DMU83KP DMU83KP DN 1-((S)-2-aminopropyl)-1H-indazol-6-ol DMU83KP MI TT0K1SC DMU83KP MN 5-HT 2B receptor (HTR2B) DMU83KP MT DTT DMU83KP MA Inhibitor DMU83KP RN 1-((S)-2-aminopropyl)-1H-indazol-6-ol: a potent peripherally acting 5-HT2 receptor agonist with ocular hypotensive activity. J Med Chem. 2006 Jan 12;49(1):318-28. DMU83KP RU https://pubmed.ncbi.nlm.nih.gov/16392816 DMU83KP DI DMU83KP DMU83KP DN 1-((S)-2-aminopropyl)-1H-indazol-6-ol DMU83KP MI TTWJBZ5 DMU83KP MN 5-HT 2C receptor (HTR2C) DMU83KP MT DTT DMU83KP MA Inhibitor DMU83KP RN 1-((S)-2-aminopropyl)-1H-indazol-6-ol: a potent peripherally acting 5-HT2 receptor agonist with ocular hypotensive activity. J Med Chem. 2006 Jan 12;49(1):318-28. DMU83KP RU https://pubmed.ncbi.nlm.nih.gov/16392816 DMU83KP DI DMU83KP DMU83KP DN 1-((S)-2-aminopropyl)-1H-indazol-6-ol DMU83KP MI TT07C3Y DMU83KP MN 5-HT 4 receptor (HTR4) DMU83KP MT DTT DMU83KP MA Inhibitor DMU83KP RN 1-((S)-2-aminopropyl)-1H-indazol-6-ol: a potent peripherally acting 5-HT2 receptor agonist with ocular hypotensive activity. J Med Chem. 2006 Jan 12;49(1):318-28. DMU83KP RU https://pubmed.ncbi.nlm.nih.gov/16392816 DMU83KP DI DMU83KP DMU83KP DN 1-((S)-2-aminopropyl)-1H-indazol-6-ol DMU83KP MI TTWG9A4 DMU83KP MN Adrenergic receptor alpha-2A (ADRA2A) DMU83KP MT DTT DMU83KP MA Inhibitor DMU83KP RN 1-((S)-2-aminopropyl)-1H-indazol-6-ol: a potent peripherally acting 5-HT2 receptor agonist with ocular hypotensive activity. J Med Chem. 2006 Jan 12;49(1):318-28. DMU83KP RU https://pubmed.ncbi.nlm.nih.gov/16392816 DMU83KP DI DMU83KP DMU83KP DN 1-((S)-2-aminopropyl)-1H-indazol-6-ol DMU83KP MI TT2NUT5 DMU83KP MN Adrenergic receptor alpha-2C (ADRA2C) DMU83KP MT DTT DMU83KP MA Inhibitor DMU83KP RN 1-((S)-2-aminopropyl)-1H-indazol-6-ol: a potent peripherally acting 5-HT2 receptor agonist with ocular hypotensive activity. J Med Chem. 2006 Jan 12;49(1):318-28. DMU83KP RU https://pubmed.ncbi.nlm.nih.gov/16392816 DMRFJNC DI DMRFJNC DMRFJNC DN 1-((S)-2-aminopropyl)-7-chloro-1H-indazol-6-ol DMRFJNC MI TTJQOD7 DMRFJNC MN 5-HT 2A receptor (HTR2A) DMRFJNC MT DTT DMRFJNC MA Inhibitor DMRFJNC RN 1-((S)-2-aminopropyl)-1H-indazol-6-ol: a potent peripherally acting 5-HT2 receptor agonist with ocular hypotensive activity. J Med Chem. 2006 Jan 12;49(1):318-28. DMRFJNC RU https://pubmed.ncbi.nlm.nih.gov/16392816 DMRFJNC DI DMRFJNC DMRFJNC DN 1-((S)-2-aminopropyl)-7-chloro-1H-indazol-6-ol DMRFJNC MI TT0K1SC DMRFJNC MN 5-HT 2B receptor (HTR2B) DMRFJNC MT DTT DMRFJNC MA Inhibitor DMRFJNC RN 1-((S)-2-aminopropyl)-1H-indazol-6-ol: a potent peripherally acting 5-HT2 receptor agonist with ocular hypotensive activity. J Med Chem. 2006 Jan 12;49(1):318-28. DMRFJNC RU https://pubmed.ncbi.nlm.nih.gov/16392816 DMRFJNC DI DMRFJNC DMRFJNC DN 1-((S)-2-aminopropyl)-7-chloro-1H-indazol-6-ol DMRFJNC MI TTWJBZ5 DMRFJNC MN 5-HT 2C receptor (HTR2C) DMRFJNC MT DTT DMRFJNC MA Inhibitor DMRFJNC RN 1-((S)-2-aminopropyl)-1H-indazol-6-ol: a potent peripherally acting 5-HT2 receptor agonist with ocular hypotensive activity. J Med Chem. 2006 Jan 12;49(1):318-28. DMRFJNC RU https://pubmed.ncbi.nlm.nih.gov/16392816 DM76JVB DI DM76JVB DM76JVB DN 1-((S)-2-aminopropyl)-7-fluoro-1H-indazol-6-ol DM76JVB MI TTJQOD7 DM76JVB MN 5-HT 2A receptor (HTR2A) DM76JVB MT DTT DM76JVB MA Inhibitor DM76JVB RN 1-((S)-2-aminopropyl)-1H-indazol-6-ol: a potent peripherally acting 5-HT2 receptor agonist with ocular hypotensive activity. J Med Chem. 2006 Jan 12;49(1):318-28. DM76JVB RU https://pubmed.ncbi.nlm.nih.gov/16392816 DM76JVB DI DM76JVB DM76JVB DN 1-((S)-2-aminopropyl)-7-fluoro-1H-indazol-6-ol DM76JVB MI TT0K1SC DM76JVB MN 5-HT 2B receptor (HTR2B) DM76JVB MT DTT DM76JVB MA Inhibitor DM76JVB RN 1-((S)-2-aminopropyl)-1H-indazol-6-ol: a potent peripherally acting 5-HT2 receptor agonist with ocular hypotensive activity. J Med Chem. 2006 Jan 12;49(1):318-28. DM76JVB RU https://pubmed.ncbi.nlm.nih.gov/16392816 DM76JVB DI DM76JVB DM76JVB DN 1-((S)-2-aminopropyl)-7-fluoro-1H-indazol-6-ol DM76JVB MI TTWJBZ5 DM76JVB MN 5-HT 2C receptor (HTR2C) DM76JVB MT DTT DM76JVB MA Inhibitor DM76JVB RN 1-((S)-2-aminopropyl)-1H-indazol-6-ol: a potent peripherally acting 5-HT2 receptor agonist with ocular hypotensive activity. J Med Chem. 2006 Jan 12;49(1):318-28. DM76JVB RU https://pubmed.ncbi.nlm.nih.gov/16392816 DMR2SXL DI DMR2SXL DMR2SXL DN 1-((S)-2-aminopropyl)-7-iodo-1H-indazol-6-ol DMR2SXL MI TTJQOD7 DMR2SXL MN 5-HT 2A receptor (HTR2A) DMR2SXL MT DTT DMR2SXL MA Inhibitor DMR2SXL RN 1-((S)-2-aminopropyl)-1H-indazol-6-ol: a potent peripherally acting 5-HT2 receptor agonist with ocular hypotensive activity. J Med Chem. 2006 Jan 12;49(1):318-28. DMR2SXL RU https://pubmed.ncbi.nlm.nih.gov/16392816 DMR2SXL DI DMR2SXL DMR2SXL DN 1-((S)-2-aminopropyl)-7-iodo-1H-indazol-6-ol DMR2SXL MI TT0K1SC DMR2SXL MN 5-HT 2B receptor (HTR2B) DMR2SXL MT DTT DMR2SXL MA Inhibitor DMR2SXL RN 1-((S)-2-aminopropyl)-1H-indazol-6-ol: a potent peripherally acting 5-HT2 receptor agonist with ocular hypotensive activity. J Med Chem. 2006 Jan 12;49(1):318-28. DMR2SXL RU https://pubmed.ncbi.nlm.nih.gov/16392816 DMR2SXL DI DMR2SXL DMR2SXL DN 1-((S)-2-aminopropyl)-7-iodo-1H-indazol-6-ol DMR2SXL MI TTWJBZ5 DMR2SXL MN 5-HT 2C receptor (HTR2C) DMR2SXL MT DTT DMR2SXL MA Inhibitor DMR2SXL RN 1-((S)-2-aminopropyl)-1H-indazol-6-ol: a potent peripherally acting 5-HT2 receptor agonist with ocular hypotensive activity. J Med Chem. 2006 Jan 12;49(1):318-28. DMR2SXL RU https://pubmed.ncbi.nlm.nih.gov/16392816 DM8MNZG DI DM8MNZG DM8MNZG DN 1-((S)-2-aminopropyl)-7-methyl-1H-indazol-6-ol DM8MNZG MI TTJQOD7 DM8MNZG MN 5-HT 2A receptor (HTR2A) DM8MNZG MT DTT DM8MNZG MA Inhibitor DM8MNZG RN 1-((S)-2-aminopropyl)-1H-indazol-6-ol: a potent peripherally acting 5-HT2 receptor agonist with ocular hypotensive activity. J Med Chem. 2006 Jan 12;49(1):318-28. DM8MNZG RU https://pubmed.ncbi.nlm.nih.gov/16392816 DM8MNZG DI DM8MNZG DM8MNZG DN 1-((S)-2-aminopropyl)-7-methyl-1H-indazol-6-ol DM8MNZG MI TT0K1SC DM8MNZG MN 5-HT 2B receptor (HTR2B) DM8MNZG MT DTT DM8MNZG MA Inhibitor DM8MNZG RN 1-((S)-2-aminopropyl)-1H-indazol-6-ol: a potent peripherally acting 5-HT2 receptor agonist with ocular hypotensive activity. J Med Chem. 2006 Jan 12;49(1):318-28. DM8MNZG RU https://pubmed.ncbi.nlm.nih.gov/16392816 DM8MNZG DI DM8MNZG DM8MNZG DN 1-((S)-2-aminopropyl)-7-methyl-1H-indazol-6-ol DM8MNZG MI TTWJBZ5 DM8MNZG MN 5-HT 2C receptor (HTR2C) DM8MNZG MT DTT DM8MNZG MA Inhibitor DM8MNZG RN 1-((S)-2-aminopropyl)-1H-indazol-6-ol: a potent peripherally acting 5-HT2 receptor agonist with ocular hypotensive activity. J Med Chem. 2006 Jan 12;49(1):318-28. DM8MNZG RU https://pubmed.ncbi.nlm.nih.gov/16392816 DMCSOAV DI DMCSOAV DMCSOAV DN 1-(1-(2-FLUOROPHENYL)-2-(2-(TRIFLUOROMETHOXY)PHENYL)ETHYL)PIPERAZINE (ENANTIOMERIC MIX) DMCSOAV MI TTAWNKZ DMCSOAV MN Norepinephrine transporter (NET) DMCSOAV MT DTT DMCSOAV MA Inhibitor DMCSOAV RN Second generation N-(1,2-diphenylethyl)piperazines as dual serotonin and noradrenaline reuptake inhibitors: improving metabolic stability and reduc... Bioorg Med Chem Lett. 2010 Jun 15;20(12):3788-92. DMCSOAV RU https://pubmed.ncbi.nlm.nih.gov/20471260 DMCSOAV DI DMCSOAV DMCSOAV DN 1-(1-(2-FLUOROPHENYL)-2-(2-(TRIFLUOROMETHOXY)PHENYL)ETHYL)PIPERAZINE (ENANTIOMERIC MIX) DMCSOAV MI TT3ROYC DMCSOAV MN Serotonin transporter (SERT) DMCSOAV MT DTT DMCSOAV MA Inhibitor DMCSOAV RN Second generation N-(1,2-diphenylethyl)piperazines as dual serotonin and noradrenaline reuptake inhibitors: improving metabolic stability and reduc... Bioorg Med Chem Lett. 2010 Jun 15;20(12):3788-92. DMCSOAV RU https://pubmed.ncbi.nlm.nih.gov/20471260 DMCSOAV DI DMCSOAV DMCSOAV DN 1-(1-(2-FLUOROPHENYL)-2-(2-(TRIFLUOROMETHOXY)PHENYL)ETHYL)PIPERAZINE (ENANTIOMERIC MIX) DMCSOAV MI TTQ6VDM DMCSOAV MN Voltage-gated potassium channel Kv11.1 (KCNH2) DMCSOAV MT DTT DMCSOAV MA Inhibitor DMCSOAV RN Second generation N-(1,2-diphenylethyl)piperazines as dual serotonin and noradrenaline reuptake inhibitors: improving metabolic stability and reduc... Bioorg Med Chem Lett. 2010 Jun 15;20(12):3788-92. DMCSOAV RU https://pubmed.ncbi.nlm.nih.gov/20471260 DM0XNMP DI DM0XNMP DM0XNMP DN 1-(1-(3-nitrophenyl)propylidene)thiosemicarbazide DM0XNMP MI TTEAID7 DM0XNMP MN Trypanosoma Cruzipain (Trypano CYSP) DM0XNMP MT DTT DM0XNMP MA Inhibitor DM0XNMP RN Design, synthesis, and biochemical evaluation of novel cruzain inhibitors with potential application in the treatment of Chagas' disease. Bioorg Med Chem Lett. 2006 Aug 15;16(16):4405-9. DM0XNMP RU https://pubmed.ncbi.nlm.nih.gov/16781147 DMXJ58Z DI DMXJ58Z DMXJ58Z DN 1-(1-(4-bromophenyl)ethylidene)thiosemicarbazide DMXJ58Z MI TTULVH8 DMXJ58Z MN Tyrosinase (TYR) DMXJ58Z MT DTT DMXJ58Z MA Inhibitor DMXJ58Z RN 1-(1-Arylethylidene)thiosemicarbazide derivatives: a new class of tyrosinase inhibitors. Bioorg Med Chem. 2008 Feb 1;16(3):1096-102. DMXJ58Z RU https://pubmed.ncbi.nlm.nih.gov/18326070 DMOQPKT DI DMOQPKT DMOQPKT DN 1-(1-(4'-Ethylbiphenyl-4-yl)propyl)-1H-imidazole DMOQPKT MI TTRA5BZ DMOQPKT MN Steroid 17-alpha-monooxygenase (S17AH) DMOQPKT MT DTT DMOQPKT MA Inhibitor DMOQPKT RN Synthesis, biological evaluation, and molecular modeling studies of methylene imidazole substituted biaryls as inhibitors of human 17alpha-hydroxyl... Bioorg Med Chem. 2008 Aug 15;16(16):7715-27. DMOQPKT RU https://pubmed.ncbi.nlm.nih.gov/18674917 DMS9PZ7 DI DMS9PZ7 DMS9PZ7 DN 1-(1-(4-FLUOROPHENYL)-2-(2-(TRIFLUOROMETHOXY)PHENYL)ETHYL)PIPERAZINE (ENANTIOMERIC MIX) DMS9PZ7 MI TTVBI8W DMS9PZ7 MN Dopamine transporter (DAT) DMS9PZ7 MT DTT DMS9PZ7 MA Inhibitor DMS9PZ7 RN Second generation N-(1,2-diphenylethyl)piperazines as dual serotonin and noradrenaline reuptake inhibitors: improving metabolic stability and reduc... Bioorg Med Chem Lett. 2010 Jun 15;20(12):3788-92. DMS9PZ7 RU https://pubmed.ncbi.nlm.nih.gov/20471260 DMS9PZ7 DI DMS9PZ7 DMS9PZ7 DN 1-(1-(4-FLUOROPHENYL)-2-(2-(TRIFLUOROMETHOXY)PHENYL)ETHYL)PIPERAZINE (ENANTIOMERIC MIX) DMS9PZ7 MI TTAWNKZ DMS9PZ7 MN Norepinephrine transporter (NET) DMS9PZ7 MT DTT DMS9PZ7 MA Inhibitor DMS9PZ7 RN Second generation N-(1,2-diphenylethyl)piperazines as dual serotonin and noradrenaline reuptake inhibitors: improving metabolic stability and reduc... Bioorg Med Chem Lett. 2010 Jun 15;20(12):3788-92. DMS9PZ7 RU https://pubmed.ncbi.nlm.nih.gov/20471260 DMS9PZ7 DI DMS9PZ7 DMS9PZ7 DN 1-(1-(4-FLUOROPHENYL)-2-(2-(TRIFLUOROMETHOXY)PHENYL)ETHYL)PIPERAZINE (ENANTIOMERIC MIX) DMS9PZ7 MI TT3ROYC DMS9PZ7 MN Serotonin transporter (SERT) DMS9PZ7 MT DTT DMS9PZ7 MA Inhibitor DMS9PZ7 RN Second generation N-(1,2-diphenylethyl)piperazines as dual serotonin and noradrenaline reuptake inhibitors: improving metabolic stability and reduc... Bioorg Med Chem Lett. 2010 Jun 15;20(12):3788-92. DMS9PZ7 RU https://pubmed.ncbi.nlm.nih.gov/20471260 DMS9PZ7 DI DMS9PZ7 DMS9PZ7 DN 1-(1-(4-FLUOROPHENYL)-2-(2-(TRIFLUOROMETHOXY)PHENYL)ETHYL)PIPERAZINE (ENANTIOMERIC MIX) DMS9PZ7 MI TTQ6VDM DMS9PZ7 MN Voltage-gated potassium channel Kv11.1 (KCNH2) DMS9PZ7 MT DTT DMS9PZ7 MA Inhibitor DMS9PZ7 RN Second generation N-(1,2-diphenylethyl)piperazines as dual serotonin and noradrenaline reuptake inhibitors: improving metabolic stability and reduc... Bioorg Med Chem Lett. 2010 Jun 15;20(12):3788-92. DMS9PZ7 RU https://pubmed.ncbi.nlm.nih.gov/20471260 DMQBHGK DI DMQBHGK DMQBHGK DN 1-(1-(4-fluorophenyl)ethylidene)thiosemicarbazide DMQBHGK MI TTULVH8 DMQBHGK MN Tyrosinase (TYR) DMQBHGK MT DTT DMQBHGK MA Inhibitor DMQBHGK RN 1-(1-Arylethylidene)thiosemicarbazide derivatives: a new class of tyrosinase inhibitors. Bioorg Med Chem. 2008 Feb 1;16(3):1096-102. DMQBHGK RU https://pubmed.ncbi.nlm.nih.gov/18326070 DMEIH5N DI DMEIH5N DMEIH5N DN 1-(1-(4-thiophen-3-ylphenyl)ethyl)-1H-imidazole DMEIH5N MI TTRA5BZ DMEIH5N MN Steroid 17-alpha-monooxygenase (S17AH) DMEIH5N MT DTT DMEIH5N MA Inhibitor DMEIH5N RN Synthesis, biological evaluation and molecular modelling studies of methyleneimidazole substituted biaryls as inhibitors of human 17alpha-hydroxyla... Bioorg Med Chem. 2008 Feb 15;16(4):1992-2010. DMEIH5N RU https://pubmed.ncbi.nlm.nih.gov/18061460 DMQF2N5 DI DMQF2N5 DMQF2N5 DN 1-(1-(4-thiophen-3-yl-phenyl)propyl)-1Himidazole DMQF2N5 MI TTRA5BZ DMQF2N5 MN Steroid 17-alpha-monooxygenase (S17AH) DMQF2N5 MT DTT DMQF2N5 MA Inhibitor DMQF2N5 RN Synthesis, biological evaluation and molecular modelling studies of methyleneimidazole substituted biaryls as inhibitors of human 17alpha-hydroxyla... Bioorg Med Chem. 2008 Feb 15;16(4):1992-2010. DMQF2N5 RU https://pubmed.ncbi.nlm.nih.gov/18061460 DMPGM0V DI DMPGM0V DMPGM0V DN 1-(1-(benzo[b]thiophen-2-yl)cyclohexyl)piperidine DMPGM0V MI TTVBI8W DMPGM0V MN Dopamine transporter (DAT) DMPGM0V MT DTT DMPGM0V MA Inhibitor DMPGM0V RN Identification of a potent, selective, and orally active leukotriene a4 hydrolase inhibitor with anti-inflammatory activity. J Med Chem. 2008 Jul 24;51(14):4150-69. DMPGM0V RU https://pubmed.ncbi.nlm.nih.gov/18588282 DMLJ7WA DI DMLJ7WA DMLJ7WA DN 1-(1-(Biphenyl-4-yl)allyl)-1H-imidazole DMLJ7WA MI TTRA5BZ DMLJ7WA MN Steroid 17-alpha-monooxygenase (S17AH) DMLJ7WA MT DTT DMLJ7WA MA Inhibitor DMLJ7WA RN Synthesis, biological evaluation, and molecular modeling studies of methylene imidazole substituted biaryls as inhibitors of human 17alpha-hydroxyl... Bioorg Med Chem. 2008 Aug 15;16(16):7715-27. DMLJ7WA RU https://pubmed.ncbi.nlm.nih.gov/18674917 DM7WJOY DI DM7WJOY DM7WJOY DN 1-(1-(pyrazin-2-yl)ethylidene)thiosemicarbazide DM7WJOY MI TTULVH8 DM7WJOY MN Tyrosinase (TYR) DM7WJOY MT DTT DM7WJOY MA Inhibitor DM7WJOY RN 1-(1-Arylethylidene)thiosemicarbazide derivatives: a new class of tyrosinase inhibitors. Bioorg Med Chem. 2008 Feb 1;16(3):1096-102. DM7WJOY RU https://pubmed.ncbi.nlm.nih.gov/18326070 DMJ21XT DI DMJ21XT DMJ21XT DN 1-(1-(pyridin-3-yl)ethylidene)thiosemicarbazide DMJ21XT MI TTULVH8 DMJ21XT MN Tyrosinase (TYR) DMJ21XT MT DTT DMJ21XT MA Inhibitor DMJ21XT RN 1-(1-Arylethylidene)thiosemicarbazide derivatives: a new class of tyrosinase inhibitors. Bioorg Med Chem. 2008 Feb 1;16(3):1096-102. DMJ21XT RU https://pubmed.ncbi.nlm.nih.gov/18326070 DMQSEF6 DI DMQSEF6 DMQSEF6 DN 1-(1-(thiophen-2-yl)ethylidene)thiosemicarbazide DMQSEF6 MI TTULVH8 DMQSEF6 MN Tyrosinase (TYR) DMQSEF6 MT DTT DMQSEF6 MA Inhibitor DMQSEF6 RN 1-(1-Arylethylidene)thiosemicarbazide derivatives: a new class of tyrosinase inhibitors. Bioorg Med Chem. 2008 Feb 1;16(3):1096-102. DMQSEF6 RU https://pubmed.ncbi.nlm.nih.gov/18326070 DMPMLZF DI DMPMLZF DMPMLZF DN 1-(1,2,4-Oxadiazol-3-yl)-7-phenylheptan-1-one DMPMLZF MI TTDP1UC DMPMLZF MN Fatty acid amide hydrolase (FAAH) DMPMLZF MT DTT DMPMLZF MA Inhibitor DMPMLZF RN Optimization of the central heterocycle of alpha-ketoheterocycle inhibitors of fatty acid amide hydrolase. J Med Chem. 2008 Aug 14;51(15):4392-403. DMPMLZF RU https://pubmed.ncbi.nlm.nih.gov/18630870 DMBS90M DI DMBS90M DMBS90M DN 1-(1,2,4-Oxadiazol-5-yl)-7-phenylheptan-1-one DMBS90M MI TTDP1UC DMBS90M MN Fatty acid amide hydrolase (FAAH) DMBS90M MT DTT DMBS90M MA Inhibitor DMBS90M RN Optimization of the central heterocycle of alpha-ketoheterocycle inhibitors of fatty acid amide hydrolase. J Med Chem. 2008 Aug 14;51(15):4392-403. DMBS90M RU https://pubmed.ncbi.nlm.nih.gov/18630870 DMOR9EK DI DMOR9EK DMOR9EK DN 1-(1,2-diphenylethyl)-4-phenylpiperidin-4-ol DMOR9EK MI TTNT7K8 DMOR9EK MN Nociceptin receptor (OPRL1) DMOR9EK MT DTT DMOR9EK MA Inhibitor DMOR9EK RN Bioorg Med Chem Lett. 2007 Jun 1;17(11):3023-7. Epub 2007 Mar 23.Synthesis and structure-activity relationships of 4-hydroxy-4-phenylpiperidines as nociceptin receptor ligands: Part 1. DMOR9EK RU https://pubmed.ncbi.nlm.nih.gov/17428659 DMOR9EK DI DMOR9EK DMOR9EK DN 1-(1,2-diphenylethyl)-4-phenylpiperidin-4-ol DMOR9EK MI TT27RFC DMOR9EK MN Opioid receptor delta (OPRD1) DMOR9EK MT DTT DMOR9EK MA Inhibitor DMOR9EK RN Bioorg Med Chem Lett. 2007 Jun 1;17(11):3023-7. Epub 2007 Mar 23.Synthesis and structure-activity relationships of 4-hydroxy-4-phenylpiperidines as nociceptin receptor ligands: Part 1. DMOR9EK RU https://pubmed.ncbi.nlm.nih.gov/17428659 DMOR9EK DI DMOR9EK DMOR9EK DN 1-(1,2-diphenylethyl)-4-phenylpiperidin-4-ol DMOR9EK MI TTQW87Y DMOR9EK MN Opioid receptor kappa (OPRK1) DMOR9EK MT DTT DMOR9EK MA Inhibitor DMOR9EK RN Bioorg Med Chem Lett. 2007 Jun 1;17(11):3023-7. Epub 2007 Mar 23.Synthesis and structure-activity relationships of 4-hydroxy-4-phenylpiperidines as nociceptin receptor ligands: Part 1. DMOR9EK RU https://pubmed.ncbi.nlm.nih.gov/17428659 DMOR9EK DI DMOR9EK DMOR9EK DN 1-(1,2-diphenylethyl)-4-phenylpiperidin-4-ol DMOR9EK MI TTKWM86 DMOR9EK MN Opioid receptor mu (MOP) DMOR9EK MT DTT DMOR9EK MA Inhibitor DMOR9EK RN Bioorg Med Chem Lett. 2007 Jun 1;17(11):3023-7. Epub 2007 Mar 23.Synthesis and structure-activity relationships of 4-hydroxy-4-phenylpiperidines as nociceptin receptor ligands: Part 1. DMOR9EK RU https://pubmed.ncbi.nlm.nih.gov/17428659 DM0ARKB DI DM0ARKB DM0ARKB DN 1-(1,2-diphenylethyl)piperazine DM0ARKB MI TTAWNKZ DM0ARKB MN Norepinephrine transporter (NET) DM0ARKB MT DTT DM0ARKB MA Inhibitor DM0ARKB RN N-(1,2-diphenylethyl)piperazines: a new class of dual serotonin/noradrenaline reuptake inhibitor. Bioorg Med Chem Lett. 2006 Aug 15;16(16):4345-8. DM0ARKB RU https://pubmed.ncbi.nlm.nih.gov/16750359 DM0ARKB DI DM0ARKB DM0ARKB DN 1-(1,2-diphenylethyl)piperazine DM0ARKB MI TT3ROYC DM0ARKB MN Serotonin transporter (SERT) DM0ARKB MT DTT DM0ARKB MA Inhibitor DM0ARKB RN N-(1,2-diphenylethyl)piperazines: a new class of dual serotonin/noradrenaline reuptake inhibitor. Bioorg Med Chem Lett. 2006 Aug 15;16(16):4345-8. DM0ARKB RU https://pubmed.ncbi.nlm.nih.gov/16750359 DMHIYB3 DI DMHIYB3 DMHIYB3 DN 1-(1,3,4-Oxadiazol-2-yl)-7-phenylheptan-1-one DMHIYB3 MI TTDP1UC DMHIYB3 MN Fatty acid amide hydrolase (FAAH) DMHIYB3 MT DTT DMHIYB3 MA Inhibitor DMHIYB3 RN Optimization of the central heterocycle of alpha-ketoheterocycle inhibitors of fatty acid amide hydrolase. J Med Chem. 2008 Aug 14;51(15):4392-403. DMHIYB3 RU https://pubmed.ncbi.nlm.nih.gov/18630870 DMZ1GH0 DI DMZ1GH0 DMZ1GH0 DN 1-(1,3,4-oxadiazol-2-yl)octadec-9-en-1-one DMZ1GH0 MI TTDP1UC DMZ1GH0 MN Fatty acid amide hydrolase (FAAH) DMZ1GH0 MT DTT DMZ1GH0 MA Inhibitor DMZ1GH0 RN Optimization of the central heterocycle of alpha-ketoheterocycle inhibitors of fatty acid amide hydrolase. J Med Chem. 2008 Aug 14;51(15):4392-403. DMZ1GH0 RU https://pubmed.ncbi.nlm.nih.gov/18630870 DM6B14Q DI DM6B14Q DM6B14Q DN 1-(1,3,4-thiadiazol-2-yl)octadec-9-en-1-one DM6B14Q MI TTDP1UC DM6B14Q MN Fatty acid amide hydrolase (FAAH) DM6B14Q MT DTT DM6B14Q MA Inhibitor DM6B14Q RN Optimization of the central heterocycle of alpha-ketoheterocycle inhibitors of fatty acid amide hydrolase. J Med Chem. 2008 Aug 14;51(15):4392-403. DM6B14Q RU https://pubmed.ncbi.nlm.nih.gov/18630870 DMTC98X DI DMTC98X DMTC98X DN 1-(1,3-diphenylpropyl)piperazine DMTC98X MI TT3ROYC DMTC98X MN Serotonin transporter (SERT) DMTC98X MT DTT DMTC98X MA Inhibitor DMTC98X RN Structure-activity relationships of N-substituted piperazine amine reuptake inhibitors. Bioorg Med Chem Lett. 2006 Aug 15;16(16):4349-53. DMTC98X RU https://pubmed.ncbi.nlm.nih.gov/16750363 DMYI3F5 DI DMYI3F5 DMYI3F5 DN 1-(1,3-diphenylpropylidene)thiosemicarbazide DMYI3F5 MI TT36ETB DMYI3F5 MN Cathepsin L (CTSL) DMYI3F5 MT DTT DMYI3F5 MA Inhibitor DMYI3F5 RN Discovery of trypanocidal thiosemicarbazone inhibitors of rhodesain and TbcatB. Bioorg Med Chem Lett. 2008 May 1;18(9):2883-5. DMYI3F5 RU https://pubmed.ncbi.nlm.nih.gov/18420405 DMHNOLA DI DMHNOLA DMHNOLA DN 1-(1,4-diacetylphenyl)dithiosemicarbazide DMHNOLA MI TTULVH8 DMHNOLA MN Tyrosinase (TYR) DMHNOLA MT DTT DMHNOLA MA Inhibitor DMHNOLA RN 1-(1-Arylethylidene)thiosemicarbazide derivatives: a new class of tyrosinase inhibitors. Bioorg Med Chem. 2008 Feb 1;16(3):1096-102. DMHNOLA RU https://pubmed.ncbi.nlm.nih.gov/18326070 DM8Z1QU DI DM8Z1QU DM8Z1QU DN 1-(1,4-diphenylbutan-2-yl)piperazine DM8Z1QU MI TTVBI8W DM8Z1QU MN Dopamine transporter (DAT) DM8Z1QU MT DTT DM8Z1QU MA Inhibitor DM8Z1QU RN Structure-activity relationships of N-substituted piperazine amine reuptake inhibitors. Bioorg Med Chem Lett. 2006 Aug 15;16(16):4349-53. DM8Z1QU RU https://pubmed.ncbi.nlm.nih.gov/16750363 DM8Z1QU DI DM8Z1QU DM8Z1QU DN 1-(1,4-diphenylbutan-2-yl)piperazine DM8Z1QU MI TTAWNKZ DM8Z1QU MN Norepinephrine transporter (NET) DM8Z1QU MT DTT DM8Z1QU MA Inhibitor DM8Z1QU RN Structure-activity relationships of N-substituted piperazine amine reuptake inhibitors. Bioorg Med Chem Lett. 2006 Aug 15;16(16):4349-53. DM8Z1QU RU https://pubmed.ncbi.nlm.nih.gov/16750363 DM8Z1QU DI DM8Z1QU DM8Z1QU DN 1-(1,4-diphenylbutan-2-yl)piperazine DM8Z1QU MI TT3ROYC DM8Z1QU MN Serotonin transporter (SERT) DM8Z1QU MT DTT DM8Z1QU MA Inhibitor DM8Z1QU RN Structure-activity relationships of N-substituted piperazine amine reuptake inhibitors. Bioorg Med Chem Lett. 2006 Aug 15;16(16):4349-53. DM8Z1QU RU https://pubmed.ncbi.nlm.nih.gov/16750363 DM2AEO0 DI DM2AEO0 DM2AEO0 DN 1-(10-Bromoanthracen-9-yl)-2-aminopropane DM2AEO0 MI TTJQOD7 DM2AEO0 MN 5-HT 2A receptor (HTR2A) DM2AEO0 MT DTT DM2AEO0 MA Inhibitor DM2AEO0 RN The role of lipophilicity in determining binding affinity and functional activity for 5-HT2A receptor ligands. Bioorg Med Chem. 2008 Apr 15;16(8):4661-9. DM2AEO0 RU https://pubmed.ncbi.nlm.nih.gov/18296055 DMKIWBT DI DMKIWBT DMKIWBT DN 1-(10H-phenothiazin-10-yl)-2-phenylbutan-1-one DMKIWBT MI TTEB0GD DMKIWBT MN Cholinesterase (BCHE) DMKIWBT MT DTT DMKIWBT MA Inhibitor DMKIWBT RN Selective reversible inhibition of human butyrylcholinesterase by aryl amide derivatives of phenothiazine. Bioorg Med Chem. 2007 Oct 1;15(19):6367-78. DMKIWBT RU https://pubmed.ncbi.nlm.nih.gov/17681768 DM5WBMY DI DM5WBMY DM5WBMY DN 1-(10H-phenothiazin-10-yl)-2-phenylethanone DM5WBMY MI TTEB0GD DM5WBMY MN Cholinesterase (BCHE) DM5WBMY MT DTT DM5WBMY MA Inhibitor DM5WBMY RN Selective reversible inhibition of human butyrylcholinesterase by aryl amide derivatives of phenothiazine. Bioorg Med Chem. 2007 Oct 1;15(19):6367-78. DM5WBMY RU https://pubmed.ncbi.nlm.nih.gov/17681768 DMYWG7D DI DMYWG7D DMYWG7D DN 1-(10H-phenothiazin-10-yl)-2-phenylpropan-1-one DMYWG7D MI TTEB0GD DMYWG7D MN Cholinesterase (BCHE) DMYWG7D MT DTT DMYWG7D MA Inhibitor DMYWG7D RN Selective reversible inhibition of human butyrylcholinesterase by aryl amide derivatives of phenothiazine. Bioorg Med Chem. 2007 Oct 1;15(19):6367-78. DMYWG7D RU https://pubmed.ncbi.nlm.nih.gov/17681768 DMZCPAQ DI DMZCPAQ DMZCPAQ DN 1-(10H-phenothiazin-10-yl)-3-phenylbutan-1-one DMZCPAQ MI TTEB0GD DMZCPAQ MN Cholinesterase (BCHE) DMZCPAQ MT DTT DMZCPAQ MA Inhibitor DMZCPAQ RN Selective reversible inhibition of human butyrylcholinesterase by aryl amide derivatives of phenothiazine. Bioorg Med Chem. 2007 Oct 1;15(19):6367-78. DMZCPAQ RU https://pubmed.ncbi.nlm.nih.gov/17681768 DMJQNLR DI DMJQNLR DMJQNLR DN 1-(10H-phenothiazin-10-yl)-3-phenylpropan-1-one DMJQNLR MI TTEB0GD DMJQNLR MN Cholinesterase (BCHE) DMJQNLR MT DTT DMJQNLR MA Inhibitor DMJQNLR RN Selective reversible inhibition of human butyrylcholinesterase by aryl amide derivatives of phenothiazine. Bioorg Med Chem. 2007 Oct 1;15(19):6367-78. DMJQNLR RU https://pubmed.ncbi.nlm.nih.gov/17681768 DMGY32O DI DMGY32O DMGY32O DN 1-(10H-phenothiazin-10-yl)-4-phenylbutan-1-one DMGY32O MI TTEB0GD DMGY32O MN Cholinesterase (BCHE) DMGY32O MT DTT DMGY32O MA Inhibitor DMGY32O RN Selective reversible inhibition of human butyrylcholinesterase by aryl amide derivatives of phenothiazine. Bioorg Med Chem. 2007 Oct 1;15(19):6367-78. DMGY32O RU https://pubmed.ncbi.nlm.nih.gov/17681768 DM7G2AB DI DM7G2AB DM7G2AB DN 1-(1-Adamantyl)-3-(1-propionylpiperidin-4-yl)urea DM7G2AB MI TT7WVHI DM7G2AB MN Soluble epoxide hydrolase (EPHX2) DM7G2AB MT DTT DM7G2AB MA Inhibitor DM7G2AB RN 1-Aryl-3-(1-acylpiperidin-4-yl)urea inhibitors of human and murine soluble epoxide hydrolase: structure-activity relationships, pharmacokinetics, a... J Med Chem. 2010 Oct 14;53(19):7067-75. DM7G2AB RU https://pubmed.ncbi.nlm.nih.gov/20812725 DM2T1CD DI DM2T1CD DM2T1CD DN 1-(1-Benzo[b]thiophen-2-yl-cycloheptyl)-azepane DM2T1CD MI TTVBI8W DM2T1CD MN Dopamine transporter (DAT) DM2T1CD MT DTT DM2T1CD MA Inhibitor DM2T1CD RN Synthesis and biological evaluation of 1-[1-(2-benzo[b]thienyl)cyclohexyl]piperidine homologues at dopamine-uptake and phencyclidine- and sigma-bin... J Med Chem. 1993 Apr 30;36(9):1188-93. DM2T1CD RU https://pubmed.ncbi.nlm.nih.gov/8098066 DMEFP15 DI DMEFP15 DMEFP15 DN 1-(1-Benzo[b]thiophen-2-yl-cyclohexyl)-azepane DMEFP15 MI TTVBI8W DMEFP15 MN Dopamine transporter (DAT) DMEFP15 MT DTT DMEFP15 MA Inhibitor DMEFP15 RN Synthesis and biological evaluation of 1-[1-(2-benzo[b]thienyl)cyclohexyl]piperidine homologues at dopamine-uptake and phencyclidine- and sigma-bin... J Med Chem. 1993 Apr 30;36(9):1188-93. DMEFP15 RU https://pubmed.ncbi.nlm.nih.gov/8098066 DM1Q36W DI DM1Q36W DM1Q36W DN 1-(1-Benzo[b]thiophen-2-yl-cyclopentyl)-azepane DM1Q36W MI TTVBI8W DM1Q36W MN Dopamine transporter (DAT) DM1Q36W MT DTT DM1Q36W MA Inhibitor DM1Q36W RN Synthesis and biological evaluation of 1-[1-(2-benzo[b]thienyl)cyclohexyl]piperidine homologues at dopamine-uptake and phencyclidine- and sigma-bin... J Med Chem. 1993 Apr 30;36(9):1188-93. DM1Q36W RU https://pubmed.ncbi.nlm.nih.gov/8098066 DMLBCE5 DI DMLBCE5 DMLBCE5 DN 1-(1-Benzyl-2-biphenyl-4-yl-ethyl)-1H-imidazole DMLBCE5 MI TTSZLWK DMLBCE5 MN Aromatase (CYP19A1) DMLBCE5 MT DTT DMLBCE5 MA Inhibitor DMLBCE5 RN CYP19 (aromatase): exploring the scaffold flexibility for novel selective inhibitors. Bioorg Med Chem. 2008 Sep 15;16(18):8349-58. DMLBCE5 RU https://pubmed.ncbi.nlm.nih.gov/18782670 DMPEIQT DI DMPEIQT DMPEIQT DN 1-(1-Biphenyl-4-yl-2-methyl-propyl)-1H-imidazole DMPEIQT MI TTRA5BZ DMPEIQT MN Steroid 17-alpha-monooxygenase (S17AH) DMPEIQT MT DTT DMPEIQT MA Inhibitor DMPEIQT RN Synthesis, biological evaluation, and molecular modeling studies of methylene imidazole substituted biaryls as inhibitors of human 17alpha-hydroxyl... Bioorg Med Chem. 2008 Aug 15;16(16):7715-27. DMPEIQT RU https://pubmed.ncbi.nlm.nih.gov/18674917 DMCTF8X DI DMCTF8X DMCTF8X DN 1-(1-Biphenyl-4-yl-2-phenyl-ethyl)-1H-imidazole DMCTF8X MI TTRA5BZ DMCTF8X MN Steroid 17-alpha-monooxygenase (S17AH) DMCTF8X MT DTT DMCTF8X MA Inhibitor DMCTF8X RN Synthesis, biological evaluation, and molecular modeling studies of methylene imidazole substituted biaryls as inhibitors of human 17alpha-hydroxyl... Bioorg Med Chem. 2008 Aug 15;16(16):7715-27. DMCTF8X RU https://pubmed.ncbi.nlm.nih.gov/18674917 DMWME7I DI DMWME7I DMWME7I DN 1-(1-Biphenyl-4-yl-3-methyl-butyl)-1H-imidazole DMWME7I MI TTRA5BZ DMWME7I MN Steroid 17-alpha-monooxygenase (S17AH) DMWME7I MT DTT DMWME7I MA Inhibitor DMWME7I RN Synthesis, biological evaluation, and molecular modeling studies of methylene imidazole substituted biaryls as inhibitors of human 17alpha-hydroxyl... Bioorg Med Chem. 2008 Aug 15;16(16):7715-27. DMWME7I RU https://pubmed.ncbi.nlm.nih.gov/18674917 DM4XILF DI DM4XILF DM4XILF DN 1-(1-Biphenyl-4-yl-butyl)-1H-imidazole DM4XILF MI TTRA5BZ DM4XILF MN Steroid 17-alpha-monooxygenase (S17AH) DM4XILF MT DTT DM4XILF MA Inhibitor DM4XILF RN Synthesis, biological evaluation, and molecular modeling studies of methylene imidazole substituted biaryls as inhibitors of human 17alpha-hydroxyl... Bioorg Med Chem. 2008 Aug 15;16(16):7715-27. DM4XILF RU https://pubmed.ncbi.nlm.nih.gov/18674917 DMW85CH DI DMW85CH DMW85CH DN 1-(1-Biphenyl-4-yl-ethyl)-1H-imidazole DMW85CH MI TTRA5BZ DMW85CH MN Steroid 17-alpha-monooxygenase (S17AH) DMW85CH MT DTT DMW85CH MA Inhibitor DMW85CH RN Synthesis, biological evaluation, and molecular modeling studies of methylene imidazole substituted biaryls as inhibitors of human 17alpha-hydroxyl... Bioorg Med Chem. 2008 Aug 15;16(16):7715-27. DMW85CH RU https://pubmed.ncbi.nlm.nih.gov/18674917 DM3AD7E DI DM3AD7E DM3AD7E DN 1-(1-Biphenyl-4-yl-pentyl)-1H-imidazole DM3AD7E MI TTRA5BZ DM3AD7E MN Steroid 17-alpha-monooxygenase (S17AH) DM3AD7E MT DTT DM3AD7E MA Inhibitor DM3AD7E RN Synthesis, biological evaluation, and molecular modeling studies of methylene imidazole substituted biaryls as inhibitors of human 17alpha-hydroxyl... Bioorg Med Chem. 2008 Aug 15;16(16):7715-27. DM3AD7E RU https://pubmed.ncbi.nlm.nih.gov/18674917 DMGVE3F DI DMGVE3F DMGVE3F DN 1-(1-Biphenyl-4-yl-propyl)-1H-imidazole DMGVE3F MI TTRA5BZ DMGVE3F MN Steroid 17-alpha-monooxygenase (S17AH) DMGVE3F MT DTT DMGVE3F MA Inhibitor DMGVE3F RN Synthesis, biological evaluation, and molecular modeling studies of methylene imidazole substituted biaryls as inhibitors of human 17alpha-hydroxyl... Bioorg Med Chem. 2008 Aug 15;16(16):7715-27. DMGVE3F RU https://pubmed.ncbi.nlm.nih.gov/18674917 DM9MCAU DI DM9MCAU DM9MCAU DN 1-(1H-Indazol-6-yl)-3-pyridin-2-yl-urea DM9MCAU MI TT0PG8F DM9MCAU MN Cyclin-dependent kinase 4 (CDK4) DM9MCAU MT DTT DM9MCAU MA Inhibitor DM9MCAU RN Structure-based generation of a new class of potent Cdk4 inhibitors: new de novo design strategy and library design. J Med Chem. 2001 Dec 20;44(26):4615-27. DM9MCAU RU https://pubmed.ncbi.nlm.nih.gov/11741479 DMSUPCD DI DMSUPCD DMSUPCD DN 1-(1H-Indol-4-yloxy)-3-phenethylamino-propan-2-ol DMSUPCD MI TTR6W5O DMSUPCD MN Adrenergic receptor beta-1 (ADRB1) DMSUPCD MT DTT DMSUPCD MA Inhibitor DMSUPCD RN Synthesis and beta-adrenergic receptor blocking potency of 1-(substituted amino)-3-(4-indolyloxy)propan-2-ols. J Med Chem. 1986 Aug;29(8):1524-7. DMSUPCD RU https://pubmed.ncbi.nlm.nih.gov/2874227 DMSUPCD DI DMSUPCD DMSUPCD DN 1-(1H-Indol-4-yloxy)-3-phenethylamino-propan-2-ol DMSUPCD MI TTMXGCW DMSUPCD MN Adrenergic receptor beta-3 (ADRB3) DMSUPCD MT DTT DMSUPCD MA Inhibitor DMSUPCD RN Synthesis and beta-adrenergic receptor blocking potency of 1-(substituted amino)-3-(4-indolyloxy)propan-2-ols. J Med Chem. 1986 Aug;29(8):1524-7. DMSUPCD RU https://pubmed.ncbi.nlm.nih.gov/2874227 DM6X9J3 DI DM6X9J3 DM6X9J3 DN 1-(1-Naphthyl)-2-aminopropane DM6X9J3 MI TT3WG5C DM6X9J3 MN Monoamine oxidase type A (MAO-A) DM6X9J3 MT DTT DM6X9J3 MA Inhibitor DM6X9J3 RN Naphthylisopropylamine and N-benzylamphetamine derivatives as monoamine oxidase inhibitors. Bioorg Med Chem. 2009 Mar 15;17(6):2452-60. DM6X9J3 RU https://pubmed.ncbi.nlm.nih.gov/19243954 DMSUC85 DI DMSUC85 DMSUC85 DN 1-(1-phenyl-1H-tetrazol-5-ylthio)propan-2-one DMSUC85 MI TTN7BL9 DMSUC85 MN Corticosteroid 11-beta-dehydrogenase 1 (HSD11B1) DMSUC85 MT DTT DMSUC85 MA Inhibitor DMSUC85 RN Modulation of 11beta-hydroxysteroid dehydrogenase type 1 activity by 1,5-substituted 1H-tetrazoles. Bioorg Med Chem Lett. 2010 Jun 1;20(11):3265-71. DMSUC85 RU https://pubmed.ncbi.nlm.nih.gov/20452767 DM54ZKU DI DM54ZKU DM54ZKU DN 1-(1-phenyl-2-(2-propoxyphenyl)ethyl)piperazine DM54ZKU MI TTVBI8W DM54ZKU MN Dopamine transporter (DAT) DM54ZKU MT DTT DM54ZKU MA Inhibitor DM54ZKU RN Second generation N-(1,2-diphenylethyl)piperazines as dual serotonin and noradrenaline reuptake inhibitors: improving metabolic stability and reduc... Bioorg Med Chem Lett. 2010 Jun 15;20(12):3788-92. DM54ZKU RU https://pubmed.ncbi.nlm.nih.gov/20471260 DM54ZKU DI DM54ZKU DM54ZKU DN 1-(1-phenyl-2-(2-propoxyphenyl)ethyl)piperazine DM54ZKU MI TTAWNKZ DM54ZKU MN Norepinephrine transporter (NET) DM54ZKU MT DTT DM54ZKU MA Inhibitor DM54ZKU RN Second generation N-(1,2-diphenylethyl)piperazines as dual serotonin and noradrenaline reuptake inhibitors: improving metabolic stability and reduc... Bioorg Med Chem Lett. 2010 Jun 15;20(12):3788-92. DM54ZKU RU https://pubmed.ncbi.nlm.nih.gov/20471260 DM54ZKU DI DM54ZKU DM54ZKU DN 1-(1-phenyl-2-(2-propoxyphenyl)ethyl)piperazine DM54ZKU MI TT3ROYC DM54ZKU MN Serotonin transporter (SERT) DM54ZKU MT DTT DM54ZKU MA Inhibitor DM54ZKU RN Second generation N-(1,2-diphenylethyl)piperazines as dual serotonin and noradrenaline reuptake inhibitors: improving metabolic stability and reduc... Bioorg Med Chem Lett. 2010 Jun 15;20(12):3788-92. DM54ZKU RU https://pubmed.ncbi.nlm.nih.gov/20471260 DM54ZKU DI DM54ZKU DM54ZKU DN 1-(1-phenyl-2-(2-propoxyphenyl)ethyl)piperazine DM54ZKU MI TTQ6VDM DM54ZKU MN Voltage-gated potassium channel Kv11.1 (KCNH2) DM54ZKU MT DTT DM54ZKU MA Inhibitor DM54ZKU RN Second generation N-(1,2-diphenylethyl)piperazines as dual serotonin and noradrenaline reuptake inhibitors: improving metabolic stability and reduc... Bioorg Med Chem Lett. 2010 Jun 15;20(12):3788-92. DM54ZKU RU https://pubmed.ncbi.nlm.nih.gov/20471260 DMIZBP6 DI DMIZBP6 DMIZBP6 DN 1-(1-phenyl-2-(pyridin-2-yl)ethyl)piperazine DMIZBP6 MI TT3ROYC DMIZBP6 MN Serotonin transporter (SERT) DMIZBP6 MT DTT DMIZBP6 MA Inhibitor DMIZBP6 RN Structure-activity relationships of N-substituted piperazine amine reuptake inhibitors. Bioorg Med Chem Lett. 2006 Aug 15;16(16):4349-53. DMIZBP6 RU https://pubmed.ncbi.nlm.nih.gov/16750363 DMTVPZC DI DMTVPZC DMTVPZC DN 1-(1-phenyl-2-(pyridin-4-yl)ethyl)piperazine DMTVPZC MI TT3ROYC DMTVPZC MN Serotonin transporter (SERT) DMTVPZC MT DTT DMTVPZC MA Inhibitor DMTVPZC RN Structure-activity relationships of N-substituted piperazine amine reuptake inhibitors. Bioorg Med Chem Lett. 2006 Aug 15;16(16):4349-53. DMTVPZC RU https://pubmed.ncbi.nlm.nih.gov/16750363 DMZ6QX0 DI DMZ6QX0 DMZ6QX0 DN 1-(1-phenyl-2-o-tolylethyl)piperazine DMZ6QX0 MI TTAWNKZ DMZ6QX0 MN Norepinephrine transporter (NET) DMZ6QX0 MT DTT DMZ6QX0 MA Inhibitor DMZ6QX0 RN N-(1,2-diphenylethyl)piperazines: a new class of dual serotonin/noradrenaline reuptake inhibitor. Bioorg Med Chem Lett. 2006 Aug 15;16(16):4345-8. DMZ6QX0 RU https://pubmed.ncbi.nlm.nih.gov/16750359 DMZ6QX0 DI DMZ6QX0 DMZ6QX0 DN 1-(1-phenyl-2-o-tolylethyl)piperazine DMZ6QX0 MI TT3ROYC DMZ6QX0 MN Serotonin transporter (SERT) DMZ6QX0 MT DTT DMZ6QX0 MA Inhibitor DMZ6QX0 RN N-(1,2-diphenylethyl)piperazines: a new class of dual serotonin/noradrenaline reuptake inhibitor. Bioorg Med Chem Lett. 2006 Aug 15;16(16):4345-8. DMZ6QX0 RU https://pubmed.ncbi.nlm.nih.gov/16750359 DMN5SL6 DI DMN5SL6 DMN5SL6 DN 1-(1-phenylethylidene)thiosemicarbazide DMN5SL6 MI TTULVH8 DMN5SL6 MN Tyrosinase (TYR) DMN5SL6 MT DTT DMN5SL6 MA Inhibitor DMN5SL6 RN 1-(1-Arylethylidene)thiosemicarbazide derivatives: a new class of tyrosinase inhibitors. Bioorg Med Chem. 2008 Feb 1;16(3):1096-102. DMN5SL6 RU https://pubmed.ncbi.nlm.nih.gov/18326070 DMER0IY DI DMER0IY DMER0IY DN 1-(1-Phenyl-propyl)-3-thiazol-2-yl-thiourea DMER0IY MI TT84ETX DMER0IY MN Human immunodeficiency virus Reverse transcriptase (HIV RT) DMER0IY MT DTT DMER0IY MA Inhibitor DMER0IY RN Anti-HIV activity of aromatic and heterocyclic thiazolyl thiourea compounds. Bioorg Med Chem Lett. 2001 Feb 26;11(4):523-8. DMER0IY RU https://pubmed.ncbi.nlm.nih.gov/11229762 DMAZR9C DI DMAZR9C DMAZR9C DN 1-(1-Propionylpiperidin-4-yl)-3-m-tolylurea DMAZR9C MI TT7WVHI DMAZR9C MN Soluble epoxide hydrolase (EPHX2) DMAZR9C MT DTT DMAZR9C MA Inhibitor DMAZR9C RN 1-Aryl-3-(1-acylpiperidin-4-yl)urea inhibitors of human and murine soluble epoxide hydrolase: structure-activity relationships, pharmacokinetics, a... J Med Chem. 2010 Oct 14;53(19):7067-75. DMAZR9C RU https://pubmed.ncbi.nlm.nih.gov/20812725 DMUH59X DI DMUH59X DMUH59X DN 1-(1-Propionylpiperidin-4-yl)-3-o-tolylurea DMUH59X MI TT7WVHI DMUH59X MN Soluble epoxide hydrolase (EPHX2) DMUH59X MT DTT DMUH59X MA Inhibitor DMUH59X RN 1-Aryl-3-(1-acylpiperidin-4-yl)urea inhibitors of human and murine soluble epoxide hydrolase: structure-activity relationships, pharmacokinetics, a... J Med Chem. 2010 Oct 14;53(19):7067-75. DMUH59X RU https://pubmed.ncbi.nlm.nih.gov/20812725 DMWUBI4 DI DMWUBI4 DMWUBI4 DN 1-(1-Propionylpiperidin-4-yl)-3-p-tolylurea DMWUBI4 MI TT7WVHI DMWUBI4 MN Soluble epoxide hydrolase (EPHX2) DMWUBI4 MT DTT DMWUBI4 MA Inhibitor DMWUBI4 RN 1-Aryl-3-(1-acylpiperidin-4-yl)urea inhibitors of human and murine soluble epoxide hydrolase: structure-activity relationships, pharmacokinetics, a... J Med Chem. 2010 Oct 14;53(19):7067-75. DMWUBI4 RU https://pubmed.ncbi.nlm.nih.gov/20812725 DM2PQFE DI DM2PQFE DM2PQFE DN 1-(1-p-tolylethylidene)thiosemicarbazide DM2PQFE MI TTULVH8 DM2PQFE MN Tyrosinase (TYR) DM2PQFE MT DTT DM2PQFE MA Inhibitor DM2PQFE RN 1-(1-Arylethylidene)thiosemicarbazide derivatives: a new class of tyrosinase inhibitors. Bioorg Med Chem. 2008 Feb 1;16(3):1096-102. DM2PQFE RU https://pubmed.ncbi.nlm.nih.gov/18326070 DMJXKOF DI DMJXKOF DMJXKOF DN 1-(2-((3-fluorophenoxy)methyl)phenyl)piperazine DMJXKOF MI TTSQIFT DMJXKOF MN 5-HT 1A receptor (HTR1A) DMJXKOF MT DTT DMJXKOF MA Inhibitor DMJXKOF RN Discovery and pharmacological characterization of aryl piperazine and piperidine ethers as dual acting norepinephrine reuptake inhibitors and 5-HT1... Bioorg Med Chem Lett. 2009 Dec 1;19(23):6604-7. DMJXKOF RU https://pubmed.ncbi.nlm.nih.gov/19854053 DMJXKOF DI DMJXKOF DMJXKOF DN 1-(2-((3-fluorophenoxy)methyl)phenyl)piperazine DMJXKOF MI TTAWNKZ DMJXKOF MN Norepinephrine transporter (NET) DMJXKOF MT DTT DMJXKOF MA Inhibitor DMJXKOF RN Discovery and pharmacological characterization of aryl piperazine and piperidine ethers as dual acting norepinephrine reuptake inhibitors and 5-HT1... Bioorg Med Chem Lett. 2009 Dec 1;19(23):6604-7. DMJXKOF RU https://pubmed.ncbi.nlm.nih.gov/19854053 DMJXKOF DI DMJXKOF DMJXKOF DN 1-(2-((3-fluorophenoxy)methyl)phenyl)piperazine DMJXKOF MI TT3ROYC DMJXKOF MN Serotonin transporter (SERT) DMJXKOF MT DTT DMJXKOF MA Inhibitor DMJXKOF RN Discovery and pharmacological characterization of aryl piperazine and piperidine ethers as dual acting norepinephrine reuptake inhibitors and 5-HT1... Bioorg Med Chem Lett. 2009 Dec 1;19(23):6604-7. DMJXKOF RU https://pubmed.ncbi.nlm.nih.gov/19854053 DMUJ2WB DI DMUJ2WB DMUJ2WB DN 1-(2-(2-(DIFLUOROMETHOXY)PHENYL)-1-PHENYLETHYL)PIPERAZINE (ENANTIOMERIC MIX) DMUJ2WB MI TTVBI8W DMUJ2WB MN Dopamine transporter (DAT) DMUJ2WB MT DTT DMUJ2WB MA Inhibitor DMUJ2WB RN Second generation N-(1,2-diphenylethyl)piperazines as dual serotonin and noradrenaline reuptake inhibitors: improving metabolic stability and reduc... Bioorg Med Chem Lett. 2010 Jun 15;20(12):3788-92. DMUJ2WB RU https://pubmed.ncbi.nlm.nih.gov/20471260 DMUJ2WB DI DMUJ2WB DMUJ2WB DN 1-(2-(2-(DIFLUOROMETHOXY)PHENYL)-1-PHENYLETHYL)PIPERAZINE (ENANTIOMERIC MIX) DMUJ2WB MI TTAWNKZ DMUJ2WB MN Norepinephrine transporter (NET) DMUJ2WB MT DTT DMUJ2WB MA Inhibitor DMUJ2WB RN Second generation N-(1,2-diphenylethyl)piperazines as dual serotonin and noradrenaline reuptake inhibitors: improving metabolic stability and reduc... Bioorg Med Chem Lett. 2010 Jun 15;20(12):3788-92. DMUJ2WB RU https://pubmed.ncbi.nlm.nih.gov/20471260 DMUJ2WB DI DMUJ2WB DMUJ2WB DN 1-(2-(2-(DIFLUOROMETHOXY)PHENYL)-1-PHENYLETHYL)PIPERAZINE (ENANTIOMERIC MIX) DMUJ2WB MI TT3ROYC DMUJ2WB MN Serotonin transporter (SERT) DMUJ2WB MT DTT DMUJ2WB MA Inhibitor DMUJ2WB RN Second generation N-(1,2-diphenylethyl)piperazines as dual serotonin and noradrenaline reuptake inhibitors: improving metabolic stability and reduc... Bioorg Med Chem Lett. 2010 Jun 15;20(12):3788-92. DMUJ2WB RU https://pubmed.ncbi.nlm.nih.gov/20471260 DMUJ2WB DI DMUJ2WB DMUJ2WB DN 1-(2-(2-(DIFLUOROMETHOXY)PHENYL)-1-PHENYLETHYL)PIPERAZINE (ENANTIOMERIC MIX) DMUJ2WB MI TTQ6VDM DMUJ2WB MN Voltage-gated potassium channel Kv11.1 (KCNH2) DMUJ2WB MT DTT DMUJ2WB MA Inhibitor DMUJ2WB RN Second generation N-(1,2-diphenylethyl)piperazines as dual serotonin and noradrenaline reuptake inhibitors: improving metabolic stability and reduc... Bioorg Med Chem Lett. 2010 Jun 15;20(12):3788-92. DMUJ2WB RU https://pubmed.ncbi.nlm.nih.gov/20471260 DMPRALC DI DMPRALC DMPRALC DN 1-(2-(2-bromophenyl)-1-phenylethyl)piperazine DMPRALC MI TTAWNKZ DMPRALC MN Norepinephrine transporter (NET) DMPRALC MT DTT DMPRALC MA Inhibitor DMPRALC RN N-(1,2-diphenylethyl)piperazines: a new class of dual serotonin/noradrenaline reuptake inhibitor. Bioorg Med Chem Lett. 2006 Aug 15;16(16):4345-8. DMPRALC RU https://pubmed.ncbi.nlm.nih.gov/16750359 DMPRALC DI DMPRALC DMPRALC DN 1-(2-(2-bromophenyl)-1-phenylethyl)piperazine DMPRALC MI TT3ROYC DMPRALC MN Serotonin transporter (SERT) DMPRALC MT DTT DMPRALC MA Inhibitor DMPRALC RN N-(1,2-diphenylethyl)piperazines: a new class of dual serotonin/noradrenaline reuptake inhibitor. Bioorg Med Chem Lett. 2006 Aug 15;16(16):4345-8. DMPRALC RU https://pubmed.ncbi.nlm.nih.gov/16750359 DM9CVX5 DI DM9CVX5 DM9CVX5 DN 1-(2-(2-chlorophenoxy)pyridin-3-yl)piperazine DM9CVX5 MI TTSQIFT DM9CVX5 MN 5-HT 1A receptor (HTR1A) DM9CVX5 MT DTT DM9CVX5 MA Inhibitor DM9CVX5 RN Design, synthesis, and pharmacological evaluation of phenoxy pyridyl derivatives as dual norepinephrine reuptake inhibitors and 5-HT1A partial agon... Bioorg Med Chem Lett. 2010 Feb 1;20(3):1114-7. DM9CVX5 RU https://pubmed.ncbi.nlm.nih.gov/20031410 DM9CVX5 DI DM9CVX5 DM9CVX5 DN 1-(2-(2-chlorophenoxy)pyridin-3-yl)piperazine DM9CVX5 MI TTAWNKZ DM9CVX5 MN Norepinephrine transporter (NET) DM9CVX5 MT DTT DM9CVX5 MA Inhibitor DM9CVX5 RN Design, synthesis, and pharmacological evaluation of phenoxy pyridyl derivatives as dual norepinephrine reuptake inhibitors and 5-HT1A partial agon... Bioorg Med Chem Lett. 2010 Feb 1;20(3):1114-7. DM9CVX5 RU https://pubmed.ncbi.nlm.nih.gov/20031410 DMUM4YQ DI DMUM4YQ DMUM4YQ DN 1-(2-(2-chlorophenyl)-1-phenylethyl)piperazine DMUM4YQ MI TTVBI8W DMUM4YQ MN Dopamine transporter (DAT) DMUM4YQ MT DTT DMUM4YQ MA Inhibitor DMUM4YQ RN N-(1,2-diphenylethyl)piperazines: a new class of dual serotonin/noradrenaline reuptake inhibitor. Bioorg Med Chem Lett. 2006 Aug 15;16(16):4345-8. DMUM4YQ RU https://pubmed.ncbi.nlm.nih.gov/16750359 DMUM4YQ DI DMUM4YQ DMUM4YQ DN 1-(2-(2-chlorophenyl)-1-phenylethyl)piperazine DMUM4YQ MI TTAWNKZ DMUM4YQ MN Norepinephrine transporter (NET) DMUM4YQ MT DTT DMUM4YQ MA Inhibitor DMUM4YQ RN N-(1,2-diphenylethyl)piperazines: a new class of dual serotonin/noradrenaline reuptake inhibitor. Bioorg Med Chem Lett. 2006 Aug 15;16(16):4345-8. DMUM4YQ RU https://pubmed.ncbi.nlm.nih.gov/16750359 DMUM4YQ DI DMUM4YQ DMUM4YQ DN 1-(2-(2-chlorophenyl)-1-phenylethyl)piperazine DMUM4YQ MI TT3ROYC DMUM4YQ MN Serotonin transporter (SERT) DMUM4YQ MT DTT DMUM4YQ MA Inhibitor DMUM4YQ RN N-(1,2-diphenylethyl)piperazines: a new class of dual serotonin/noradrenaline reuptake inhibitor. Bioorg Med Chem Lett. 2006 Aug 15;16(16):4345-8. DMUM4YQ RU https://pubmed.ncbi.nlm.nih.gov/16750359 DMBRS3D DI DMBRS3D DMBRS3D DN 1-(2-(2-ethoxyphenyl)-1-phenylethyl)piperazine DMBRS3D MI TTAWNKZ DMBRS3D MN Norepinephrine transporter (NET) DMBRS3D MT DTT DMBRS3D MA Inhibitor DMBRS3D RN N-(1,2-diphenylethyl)piperazines: a new class of dual serotonin/noradrenaline reuptake inhibitor. Bioorg Med Chem Lett. 2006 Aug 15;16(16):4345-8. DMBRS3D RU https://pubmed.ncbi.nlm.nih.gov/16750359 DMBRS3D DI DMBRS3D DMBRS3D DN 1-(2-(2-ethoxyphenyl)-1-phenylethyl)piperazine DMBRS3D MI TT3ROYC DMBRS3D MN Serotonin transporter (SERT) DMBRS3D MT DTT DMBRS3D MA Inhibitor DMBRS3D RN N-(1,2-diphenylethyl)piperazines: a new class of dual serotonin/noradrenaline reuptake inhibitor. Bioorg Med Chem Lett. 2006 Aug 15;16(16):4345-8. DMBRS3D RU https://pubmed.ncbi.nlm.nih.gov/16750359 DMKWRCD DI DMKWRCD DMKWRCD DN 1-(2-(2-ethylphenyl)-1-phenylethyl)piperazine DMKWRCD MI TTAWNKZ DMKWRCD MN Norepinephrine transporter (NET) DMKWRCD MT DTT DMKWRCD MA Inhibitor DMKWRCD RN N-(1,2-diphenylethyl)piperazines: a new class of dual serotonin/noradrenaline reuptake inhibitor. Bioorg Med Chem Lett. 2006 Aug 15;16(16):4345-8. DMKWRCD RU https://pubmed.ncbi.nlm.nih.gov/16750359 DMKWRCD DI DMKWRCD DMKWRCD DN 1-(2-(2-ethylphenyl)-1-phenylethyl)piperazine DMKWRCD MI TT3ROYC DMKWRCD MN Serotonin transporter (SERT) DMKWRCD MT DTT DMKWRCD MA Inhibitor DMKWRCD RN N-(1,2-diphenylethyl)piperazines: a new class of dual serotonin/noradrenaline reuptake inhibitor. Bioorg Med Chem Lett. 2006 Aug 15;16(16):4345-8. DMKWRCD RU https://pubmed.ncbi.nlm.nih.gov/16750359 DM6XCPV DI DM6XCPV DM6XCPV DN 1-(2-(2-fluorobenzyloxy)phenyl)piperazine DM6XCPV MI TTSQIFT DM6XCPV MN 5-HT 1A receptor (HTR1A) DM6XCPV MT DTT DM6XCPV MA Inhibitor DM6XCPV RN Discovery and pharmacological characterization of aryl piperazine and piperidine ethers as dual acting norepinephrine reuptake inhibitors and 5-HT1... Bioorg Med Chem Lett. 2009 Dec 1;19(23):6604-7. DM6XCPV RU https://pubmed.ncbi.nlm.nih.gov/19854053 DM6XCPV DI DM6XCPV DM6XCPV DN 1-(2-(2-fluorobenzyloxy)phenyl)piperazine DM6XCPV MI TTAWNKZ DM6XCPV MN Norepinephrine transporter (NET) DM6XCPV MT DTT DM6XCPV MA Inhibitor DM6XCPV RN Discovery and pharmacological characterization of aryl piperazine and piperidine ethers as dual acting norepinephrine reuptake inhibitors and 5-HT1... Bioorg Med Chem Lett. 2009 Dec 1;19(23):6604-7. DM6XCPV RU https://pubmed.ncbi.nlm.nih.gov/19854053 DM6XCPV DI DM6XCPV DM6XCPV DN 1-(2-(2-fluorobenzyloxy)phenyl)piperazine DM6XCPV MI TT3ROYC DM6XCPV MN Serotonin transporter (SERT) DM6XCPV MT DTT DM6XCPV MA Inhibitor DM6XCPV RN Discovery and pharmacological characterization of aryl piperazine and piperidine ethers as dual acting norepinephrine reuptake inhibitors and 5-HT1... Bioorg Med Chem Lett. 2009 Dec 1;19(23):6604-7. DM6XCPV RU https://pubmed.ncbi.nlm.nih.gov/19854053 DM2H38V DI DM2H38V DM2H38V DN 1-(2-(2-methoxyphenyl)-1-phenylethyl)piperazine DM2H38V MI TTVBI8W DM2H38V MN Dopamine transporter (DAT) DM2H38V MT DTT DM2H38V MA Inhibitor DM2H38V RN N-(1,2-diphenylethyl)piperazines: a new class of dual serotonin/noradrenaline reuptake inhibitor. Bioorg Med Chem Lett. 2006 Aug 15;16(16):4345-8. DM2H38V RU https://pubmed.ncbi.nlm.nih.gov/16750359 DM2H38V DI DM2H38V DM2H38V DN 1-(2-(2-methoxyphenyl)-1-phenylethyl)piperazine DM2H38V MI TTAWNKZ DM2H38V MN Norepinephrine transporter (NET) DM2H38V MT DTT DM2H38V MA Inhibitor DM2H38V RN Second generation N-(1,2-diphenylethyl)piperazines as dual serotonin and noradrenaline reuptake inhibitors: improving metabolic stability and reduc... Bioorg Med Chem Lett. 2010 Jun 15;20(12):3788-92. DM2H38V RU https://pubmed.ncbi.nlm.nih.gov/20471260 DM2H38V DI DM2H38V DM2H38V DN 1-(2-(2-methoxyphenyl)-1-phenylethyl)piperazine DM2H38V MI TT3ROYC DM2H38V MN Serotonin transporter (SERT) DM2H38V MT DTT DM2H38V MA Inhibitor DM2H38V RN Second generation N-(1,2-diphenylethyl)piperazines as dual serotonin and noradrenaline reuptake inhibitors: improving metabolic stability and reduc... Bioorg Med Chem Lett. 2010 Jun 15;20(12):3788-92. DM2H38V RU https://pubmed.ncbi.nlm.nih.gov/20471260 DM4WEGM DI DM4WEGM DM4WEGM DN 1-(2-(3-chlorophenyl)-1-phenylethyl)piperazine DM4WEGM MI TTAWNKZ DM4WEGM MN Norepinephrine transporter (NET) DM4WEGM MT DTT DM4WEGM MA Inhibitor DM4WEGM RN N-(1,2-diphenylethyl)piperazines: a new class of dual serotonin/noradrenaline reuptake inhibitor. Bioorg Med Chem Lett. 2006 Aug 15;16(16):4345-8. DM4WEGM RU https://pubmed.ncbi.nlm.nih.gov/16750359 DM4WEGM DI DM4WEGM DM4WEGM DN 1-(2-(3-chlorophenyl)-1-phenylethyl)piperazine DM4WEGM MI TT3ROYC DM4WEGM MN Serotonin transporter (SERT) DM4WEGM MT DTT DM4WEGM MA Inhibitor DM4WEGM RN N-(1,2-diphenylethyl)piperazines: a new class of dual serotonin/noradrenaline reuptake inhibitor. Bioorg Med Chem Lett. 2006 Aug 15;16(16):4345-8. DM4WEGM RU https://pubmed.ncbi.nlm.nih.gov/16750359 DMXV2KQ DI DMXV2KQ DMXV2KQ DN 1-(2-(3-fluorophenoxy)phenyl)piperazine DMXV2KQ MI TTSQIFT DMXV2KQ MN 5-HT 1A receptor (HTR1A) DMXV2KQ MT DTT DMXV2KQ MA Inhibitor DMXV2KQ RN Discovery and pharmacological characterization of aryl piperazine and piperidine ethers as dual acting norepinephrine reuptake inhibitors and 5-HT1... Bioorg Med Chem Lett. 2009 Dec 1;19(23):6604-7. DMXV2KQ RU https://pubmed.ncbi.nlm.nih.gov/19854053 DMXV2KQ DI DMXV2KQ DMXV2KQ DN 1-(2-(3-fluorophenoxy)phenyl)piperazine DMXV2KQ MI TTAWNKZ DMXV2KQ MN Norepinephrine transporter (NET) DMXV2KQ MT DTT DMXV2KQ MA Inhibitor DMXV2KQ RN Discovery and pharmacological characterization of aryl piperazine and piperidine ethers as dual acting norepinephrine reuptake inhibitors and 5-HT1... Bioorg Med Chem Lett. 2009 Dec 1;19(23):6604-7. DMXV2KQ RU https://pubmed.ncbi.nlm.nih.gov/19854053 DMXV2KQ DI DMXV2KQ DMXV2KQ DN 1-(2-(3-fluorophenoxy)phenyl)piperazine DMXV2KQ MI TT3ROYC DMXV2KQ MN Serotonin transporter (SERT) DMXV2KQ MT DTT DMXV2KQ MA Inhibitor DMXV2KQ RN Discovery and pharmacological characterization of aryl piperazine and piperidine ethers as dual acting norepinephrine reuptake inhibitors and 5-HT1... Bioorg Med Chem Lett. 2009 Dec 1;19(23):6604-7. DMXV2KQ RU https://pubmed.ncbi.nlm.nih.gov/19854053 DM8V5IH DI DM8V5IH DM8V5IH DN 1-(2-(3-methoxyphenyl)-1-phenylethyl)piperazine DM8V5IH MI TTAWNKZ DM8V5IH MN Norepinephrine transporter (NET) DM8V5IH MT DTT DM8V5IH MA Inhibitor DM8V5IH RN N-(1,2-diphenylethyl)piperazines: a new class of dual serotonin/noradrenaline reuptake inhibitor. Bioorg Med Chem Lett. 2006 Aug 15;16(16):4345-8. DM8V5IH RU https://pubmed.ncbi.nlm.nih.gov/16750359 DM8V5IH DI DM8V5IH DM8V5IH DN 1-(2-(3-methoxyphenyl)-1-phenylethyl)piperazine DM8V5IH MI TT3ROYC DM8V5IH MN Serotonin transporter (SERT) DM8V5IH MT DTT DM8V5IH MA Inhibitor DM8V5IH RN N-(1,2-diphenylethyl)piperazines: a new class of dual serotonin/noradrenaline reuptake inhibitor. Bioorg Med Chem Lett. 2006 Aug 15;16(16):4345-8. DM8V5IH RU https://pubmed.ncbi.nlm.nih.gov/16750359 DMU082P DI DMU082P DMU082P DN 1-(2-(4-fluorophenoxy)phenyl)piperazine DMU082P MI TTSQIFT DMU082P MN 5-HT 1A receptor (HTR1A) DMU082P MT DTT DMU082P MA Inhibitor DMU082P RN Discovery and pharmacological characterization of aryl piperazine and piperidine ethers as dual acting norepinephrine reuptake inhibitors and 5-HT1... Bioorg Med Chem Lett. 2009 Dec 1;19(23):6604-7. DMU082P RU https://pubmed.ncbi.nlm.nih.gov/19854053 DMU082P DI DMU082P DMU082P DN 1-(2-(4-fluorophenoxy)phenyl)piperazine DMU082P MI TTVBI8W DMU082P MN Dopamine transporter (DAT) DMU082P MT DTT DMU082P MA Inhibitor DMU082P RN Discovery and pharmacological characterization of aryl piperazine and piperidine ethers as dual acting norepinephrine reuptake inhibitors and 5-HT1... Bioorg Med Chem Lett. 2009 Dec 1;19(23):6604-7. DMU082P RU https://pubmed.ncbi.nlm.nih.gov/19854053 DMU082P DI DMU082P DMU082P DN 1-(2-(4-fluorophenoxy)phenyl)piperazine DMU082P MI TTAWNKZ DMU082P MN Norepinephrine transporter (NET) DMU082P MT DTT DMU082P MA Inhibitor DMU082P RN Discovery and pharmacological characterization of aryl piperazine and piperidine ethers as dual acting norepinephrine reuptake inhibitors and 5-HT1... Bioorg Med Chem Lett. 2009 Dec 1;19(23):6604-7. DMU082P RU https://pubmed.ncbi.nlm.nih.gov/19854053 DMU082P DI DMU082P DMU082P DN 1-(2-(4-fluorophenoxy)phenyl)piperazine DMU082P MI TT3ROYC DMU082P MN Serotonin transporter (SERT) DMU082P MT DTT DMU082P MA Inhibitor DMU082P RN Discovery and pharmacological characterization of aryl piperazine and piperidine ethers as dual acting norepinephrine reuptake inhibitors and 5-HT1... Bioorg Med Chem Lett. 2009 Dec 1;19(23):6604-7. DMU082P RU https://pubmed.ncbi.nlm.nih.gov/19854053 DMR4DJ1 DI DMR4DJ1 DMR4DJ1 DN 1-(2-(6-fluoronaphthalen-2-yl)ethyl)piperazine DMR4DJ1 MI TTAWNKZ DMR4DJ1 MN Norepinephrine transporter (NET) DMR4DJ1 MT DTT DMR4DJ1 MA Inhibitor DMR4DJ1 RN Design and optimization of selective serotonin re-uptake inhibitors with high synthetic accessibility. Part 1. Bioorg Med Chem Lett. 2009 Apr 15;19(8):2329-32. DMR4DJ1 RU https://pubmed.ncbi.nlm.nih.gov/19282174 DMR4DJ1 DI DMR4DJ1 DMR4DJ1 DN 1-(2-(6-fluoronaphthalen-2-yl)ethyl)piperazine DMR4DJ1 MI TT3ROYC DMR4DJ1 MN Serotonin transporter (SERT) DMR4DJ1 MT DTT DMR4DJ1 MA Inhibitor DMR4DJ1 RN Design and optimization of selective serotonin re-uptake inhibitors with high synthetic accessibility. Part 1. Bioorg Med Chem Lett. 2009 Apr 15;19(8):2329-32. DMR4DJ1 RU https://pubmed.ncbi.nlm.nih.gov/19282174 DMR4DJ1 DI DMR4DJ1 DMR4DJ1 DN 1-(2-(6-fluoronaphthalen-2-yl)ethyl)piperazine DMR4DJ1 MI TTQ6VDM DMR4DJ1 MN Voltage-gated potassium channel Kv11.1 (KCNH2) DMR4DJ1 MT DTT DMR4DJ1 MA Inhibitor DMR4DJ1 RN Design and optimization of selective serotonin re-uptake inhibitors with high synthetic accessibility. Part 1. Bioorg Med Chem Lett. 2009 Apr 15;19(8):2329-32. DMR4DJ1 RU https://pubmed.ncbi.nlm.nih.gov/19282174 DMB3HI4 DI DMB3HI4 DMB3HI4 DN 1-(2-(benzo[b]thiophen-4-yl)ethyl)-1H-imidazole DMB3HI4 MI TTSZLWK DMB3HI4 MN Aromatase (CYP19A1) DMB3HI4 MT DTT DMB3HI4 MA Inhibitor DMB3HI4 RN Fast three dimensional pharmacophore virtual screening of new potent non-steroid aromatase inhibitors. J Med Chem. 2009 Jan 8;52(1):143-50. DMB3HI4 RU https://pubmed.ncbi.nlm.nih.gov/19072235 DM0UZHL DI DM0UZHL DM0UZHL DN 1-(2-(benzyloxy)phenyl)piperazine DM0UZHL MI TTSQIFT DM0UZHL MN 5-HT 1A receptor (HTR1A) DM0UZHL MT DTT DM0UZHL MA Inhibitor DM0UZHL RN Discovery and pharmacological characterization of aryl piperazine and piperidine ethers as dual acting norepinephrine reuptake inhibitors and 5-HT1... Bioorg Med Chem Lett. 2009 Dec 1;19(23):6604-7. DM0UZHL RU https://pubmed.ncbi.nlm.nih.gov/19854053 DM0UZHL DI DM0UZHL DM0UZHL DN 1-(2-(benzyloxy)phenyl)piperazine DM0UZHL MI TTAWNKZ DM0UZHL MN Norepinephrine transporter (NET) DM0UZHL MT DTT DM0UZHL MA Inhibitor DM0UZHL RN Discovery and pharmacological characterization of aryl piperazine and piperidine ethers as dual acting norepinephrine reuptake inhibitors and 5-HT1... Bioorg Med Chem Lett. 2009 Dec 1;19(23):6604-7. DM0UZHL RU https://pubmed.ncbi.nlm.nih.gov/19854053 DM0UZHL DI DM0UZHL DM0UZHL DN 1-(2-(benzyloxy)phenyl)piperazine DM0UZHL MI TT3ROYC DM0UZHL MN Serotonin transporter (SERT) DM0UZHL MT DTT DM0UZHL MA Inhibitor DM0UZHL RN Discovery and pharmacological characterization of aryl piperazine and piperidine ethers as dual acting norepinephrine reuptake inhibitors and 5-HT1... Bioorg Med Chem Lett. 2009 Dec 1;19(23):6604-7. DM0UZHL RU https://pubmed.ncbi.nlm.nih.gov/19854053 DMU5BOW DI DMU5BOW DMU5BOW DN 1-(2-(diethylamino)quinazolin-4-yl)-3-phenylurea DMU5BOW MI TTJFY5U DMU5BOW MN Adenosine A3 receptor (ADORA3) DMU5BOW MT DTT DMU5BOW MA Inhibitor DMU5BOW RN Pharmacophore based receptor modeling: the case of adenosine A3 receptor antagonists. An approach to the optimization of protein models. J Med Chem. 2006 Jul 13;49(14):4085-97. DMU5BOW RU https://pubmed.ncbi.nlm.nih.gov/16821770 DMXL7Z5 DI DMXL7Z5 DMXL7Z5 DN 1-(2-(naphthalen-1-yl)-1-phenylethyl)piperazine DMXL7Z5 MI TT3ROYC DMXL7Z5 MN Serotonin transporter (SERT) DMXL7Z5 MT DTT DMXL7Z5 MA Inhibitor DMXL7Z5 RN Structure-activity relationships of N-substituted piperazine amine reuptake inhibitors. Bioorg Med Chem Lett. 2006 Aug 15;16(16):4349-53. DMXL7Z5 RU https://pubmed.ncbi.nlm.nih.gov/16750363 DMTEBP0 DI DMTEBP0 DMTEBP0 DN 1-(2-(naphthalen-2-yl)-1-phenylethyl)piperazine DMTEBP0 MI TT3ROYC DMTEBP0 MN Serotonin transporter (SERT) DMTEBP0 MT DTT DMTEBP0 MA Inhibitor DMTEBP0 RN Structure-activity relationships of N-substituted piperazine amine reuptake inhibitors. Bioorg Med Chem Lett. 2006 Aug 15;16(16):4349-53. DMTEBP0 RU https://pubmed.ncbi.nlm.nih.gov/16750363 DMS7YF6 DI DMS7YF6 DMS7YF6 DN 1-(2-(naphthalen-2-yl)ethyl)piperazine DMS7YF6 MI TT3ROYC DMS7YF6 MN Serotonin transporter (SERT) DMS7YF6 MT DTT DMS7YF6 MA Inhibitor DMS7YF6 RN Design and optimization of selective serotonin re-uptake inhibitors with high synthetic accessibility. Part 1. Bioorg Med Chem Lett. 2009 Apr 15;19(8):2329-32. DMS7YF6 RU https://pubmed.ncbi.nlm.nih.gov/19282174 DMYFKID DI DMYFKID DMYFKID DN 1-(2-(naphthalen-2-yl)ethyl)pyrrolidine DMYFKID MI TT9JNIC DMYFKID MN Histamine H3 receptor (H3R) DMYFKID MT DTT DMYFKID MA Inhibitor DMYFKID RN In vitro SAR of pyrrolidine-containing histamine H3 receptor antagonists: trends across multiple chemical series. Bioorg Med Chem Lett. 2008 Jan 1;18(1):355-9. DMYFKID RU https://pubmed.ncbi.nlm.nih.gov/18077160 DM7Z19T DI DM7Z19T DM7Z19T DN 1-(2-(phenoxymethyl)phenyl)piperazine DM7Z19T MI TTSQIFT DM7Z19T MN 5-HT 1A receptor (HTR1A) DM7Z19T MT DTT DM7Z19T MA Inhibitor DM7Z19T RN Discovery and pharmacological characterization of aryl piperazine and piperidine ethers as dual acting norepinephrine reuptake inhibitors and 5-HT1... Bioorg Med Chem Lett. 2009 Dec 1;19(23):6604-7. DM7Z19T RU https://pubmed.ncbi.nlm.nih.gov/19854053 DM7Z19T DI DM7Z19T DM7Z19T DN 1-(2-(phenoxymethyl)phenyl)piperazine DM7Z19T MI TTVBI8W DM7Z19T MN Dopamine transporter (DAT) DM7Z19T MT DTT DM7Z19T MA Inhibitor DM7Z19T RN Discovery and pharmacological characterization of aryl piperazine and piperidine ethers as dual acting norepinephrine reuptake inhibitors and 5-HT1... Bioorg Med Chem Lett. 2009 Dec 1;19(23):6604-7. DM7Z19T RU https://pubmed.ncbi.nlm.nih.gov/19854053 DM7Z19T DI DM7Z19T DM7Z19T DN 1-(2-(phenoxymethyl)phenyl)piperazine DM7Z19T MI TTAWNKZ DM7Z19T MN Norepinephrine transporter (NET) DM7Z19T MT DTT DM7Z19T MA Inhibitor DM7Z19T RN Discovery and pharmacological characterization of aryl piperazine and piperidine ethers as dual acting norepinephrine reuptake inhibitors and 5-HT1... Bioorg Med Chem Lett. 2009 Dec 1;19(23):6604-7. DM7Z19T RU https://pubmed.ncbi.nlm.nih.gov/19854053 DM7Z19T DI DM7Z19T DM7Z19T DN 1-(2-(phenoxymethyl)phenyl)piperazine DM7Z19T MI TT3ROYC DM7Z19T MN Serotonin transporter (SERT) DM7Z19T MT DTT DM7Z19T MA Inhibitor DM7Z19T RN Discovery and pharmacological characterization of aryl piperazine and piperidine ethers as dual acting norepinephrine reuptake inhibitors and 5-HT1... Bioorg Med Chem Lett. 2009 Dec 1;19(23):6604-7. DM7Z19T RU https://pubmed.ncbi.nlm.nih.gov/19854053 DMNX6CE DI DMNX6CE DMNX6CE DN 1-(2,2'-bithiophen-5-yl)methanamine DMNX6CE MI TTXZEAJ DMNX6CE MN Leukotriene A-4 hydrolase (LTA4H) DMNX6CE MT DTT DMNX6CE MA Inhibitor DMNX6CE RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DMNX6CE RU https://pubmed.ncbi.nlm.nih.gov/10592235 DM1Q0TM DI DM1Q0TM DM1Q0TM DN 1-(2,3-DICHLOROPHENYL)-2,2,2-TRIFLUORO-1-(1-(4-FLUOROPHENYL)-1H-INDAZOL-5-YL)ETHANOL (ENANTIOMERIC MIX) DM1Q0TM MI TTOZRK6 DM1Q0TM MN Glucocorticoid receptor messenger RNA (GCR mRNA) DM1Q0TM MT DTT DM1Q0TM MA Inhibitor DM1Q0TM RN 5-Functionalized indazoles as glucocorticoid receptor agonists. Bioorg Med Chem Lett. 2010 May 15;20(10):3017-20. DM1Q0TM RU https://pubmed.ncbi.nlm.nih.gov/20427184 DM0URSE DI DM0URSE DM0URSE DN 1-(2,3-Dihydro-1H-indol-5-ylmethyl)-propylamine DM0URSE MI TTVBI8W DM0URSE MN Dopamine transporter (DAT) DM0URSE MT DTT DM0URSE MA Inhibitor DM0URSE RN Selective monoamine oxidase inhibitors. 3. Cyclic compounds related to 4-aminophenethylamine. Preparation and neuron-selective action of some 5-(2-... J Med Chem. 1986 Aug;29(8):1406-12. DM0URSE RU https://pubmed.ncbi.nlm.nih.gov/3735309 DM0URSE DI DM0URSE DM0URSE DN 1-(2,3-Dihydro-1H-indol-5-ylmethyl)-propylamine DM0URSE MI TTAWNKZ DM0URSE MN Norepinephrine transporter (NET) DM0URSE MT DTT DM0URSE MA Inhibitor DM0URSE RN Selective monoamine oxidase inhibitors. 3. Cyclic compounds related to 4-aminophenethylamine. Preparation and neuron-selective action of some 5-(2-... J Med Chem. 1986 Aug;29(8):1406-12. DM0URSE RU https://pubmed.ncbi.nlm.nih.gov/3735309 DM31CVR DI DM31CVR DM31CVR DN 1-(2,5-Dimethoxy-4-methyl-phenyl)-piperazine DM31CVR MI TTSQIFT DM31CVR MN 5-HT 1A receptor (HTR1A) DM31CVR MT DTT DM31CVR MA Inhibitor DM31CVR RN Synthesis and evaluation of phenyl- and benzoylpiperazines as potential serotonergic agents. J Med Chem. 1986 May;29(5):630-4. DM31CVR RU https://pubmed.ncbi.nlm.nih.gov/3701781 DM31CVR DI DM31CVR DM31CVR DN 1-(2,5-Dimethoxy-4-methyl-phenyl)-piperazine DM31CVR MI TT6MSOK DM31CVR MN 5-HT 1D receptor (HTR1D) DM31CVR MT DTT DM31CVR MA Inhibitor DM31CVR RN Synthesis and evaluation of phenyl- and benzoylpiperazines as potential serotonergic agents. J Med Chem. 1986 May;29(5):630-4. DM31CVR RU https://pubmed.ncbi.nlm.nih.gov/3701781 DM31CVR DI DM31CVR DM31CVR DN 1-(2,5-Dimethoxy-4-methyl-phenyl)-piperazine DM31CVR MI TTJQOD7 DM31CVR MN 5-HT 2A receptor (HTR2A) DM31CVR MT DTT DM31CVR MA Inhibitor DM31CVR RN Synthesis and evaluation of phenyl- and benzoylpiperazines as potential serotonergic agents. J Med Chem. 1986 May;29(5):630-4. DM31CVR RU https://pubmed.ncbi.nlm.nih.gov/3701781 DMNETHQ DI DMNETHQ DMNETHQ DN 1-(2,5-Dimethoxy-phenyl)-piperazine DMNETHQ MI TTSQIFT DMNETHQ MN 5-HT 1A receptor (HTR1A) DMNETHQ MT DTT DMNETHQ MA Inhibitor DMNETHQ RN Synthesis and evaluation of phenyl- and benzoylpiperazines as potential serotonergic agents. J Med Chem. 1986 May;29(5):630-4. DMNETHQ RU https://pubmed.ncbi.nlm.nih.gov/3701781 DMNETHQ DI DMNETHQ DMNETHQ DN 1-(2,5-Dimethoxy-phenyl)-piperazine DMNETHQ MI TT6MSOK DMNETHQ MN 5-HT 1D receptor (HTR1D) DMNETHQ MT DTT DMNETHQ MA Inhibitor DMNETHQ RN Synthesis and evaluation of phenyl- and benzoylpiperazines as potential serotonergic agents. J Med Chem. 1986 May;29(5):630-4. DMNETHQ RU https://pubmed.ncbi.nlm.nih.gov/3701781 DMNETHQ DI DMNETHQ DMNETHQ DN 1-(2,5-Dimethoxy-phenyl)-piperazine DMNETHQ MI TTJQOD7 DMNETHQ MN 5-HT 2A receptor (HTR2A) DMNETHQ MT DTT DMNETHQ MA Inhibitor DMNETHQ RN Synthesis and evaluation of phenyl- and benzoylpiperazines as potential serotonergic agents. J Med Chem. 1986 May;29(5):630-4. DMNETHQ RU https://pubmed.ncbi.nlm.nih.gov/3701781 DM043N8 DI DM043N8 DM043N8 DN 1-(2,5-dimethoxyphenyl)propan-2-amine DM043N8 MI TTSQIFT DM043N8 MN 5-HT 1A receptor (HTR1A) DM043N8 MT DTT DM043N8 MA Inhibitor DM043N8 RN 5-HT1 and 5-HT2 binding characteristics of 1-(2,5-dimethoxy-4-bromophenyl)-2-aminopropane analogues. J Med Chem. 1986 Feb;29(2):194-9. DM043N8 RU https://pubmed.ncbi.nlm.nih.gov/3950904 DM043N8 DI DM043N8 DM043N8 DN 1-(2,5-dimethoxyphenyl)propan-2-amine DM043N8 MI TT6MSOK DM043N8 MN 5-HT 1D receptor (HTR1D) DM043N8 MT DTT DM043N8 MA Inhibitor DM043N8 RN 5-HT1 and 5-HT2 binding characteristics of 1-(2,5-dimethoxy-4-bromophenyl)-2-aminopropane analogues. J Med Chem. 1986 Feb;29(2):194-9. DM043N8 RU https://pubmed.ncbi.nlm.nih.gov/3950904 DM043N8 DI DM043N8 DM043N8 DN 1-(2,5-dimethoxyphenyl)propan-2-amine DM043N8 MI TTJQOD7 DM043N8 MN 5-HT 2A receptor (HTR2A) DM043N8 MT DTT DM043N8 MA Inhibitor DM043N8 RN The role of lipophilicity in determining binding affinity and functional activity for 5-HT2A receptor ligands. Bioorg Med Chem. 2008 Apr 15;16(8):4661-9. DM043N8 RU https://pubmed.ncbi.nlm.nih.gov/18296055 DM3FHJK DI DM3FHJK DM3FHJK DN 1-(2,5-Dimethyl-1H-pyrrol-1-yl)thiourea DM3FHJK MI TTULVH8 DM3FHJK MN Tyrosinase (TYR) DM3FHJK MT DTT DM3FHJK MA Inhibitor DM3FHJK RN A class of potent tyrosinase inhibitors: alkylidenethiosemicarbazide compounds. Eur J Med Chem. 2009 Apr;44(4):1773-8. DM3FHJK RU https://pubmed.ncbi.nlm.nih.gov/18524420 DMV0C6F DI DMV0C6F DMV0C6F DN 1-(2,6-dimethoxy-4-methylphenyl)propan-2-amine DMV0C6F MI TTJQOD7 DMV0C6F MN 5-HT 2A receptor (HTR2A) DMV0C6F MT DTT DMV0C6F MA Inhibitor DMV0C6F RN The role of lipophilicity in determining binding affinity and functional activity for 5-HT2A receptor ligands. Bioorg Med Chem. 2008 Apr 15;16(8):4661-9. DMV0C6F RU https://pubmed.ncbi.nlm.nih.gov/18296055 DMRHY2M DI DMRHY2M DMRHY2M DN 1-(2-adamantyl)-3-benzylpyrrolidin-2-one DMRHY2M MI TTN7BL9 DMRHY2M MN Corticosteroid 11-beta-dehydrogenase 1 (HSD11B1) DMRHY2M MT DTT DMRHY2M MA Inhibitor DMRHY2M RN Discovery of orally active butyrolactam 11beta-HSD1 inhibitors. Bioorg Med Chem Lett. 2006 Nov 1;16(21):5555-60. DMRHY2M RU https://pubmed.ncbi.nlm.nih.gov/16931002 DMLV0PQ DI DMLV0PQ DMLV0PQ DN 1-(2-allylphenoxy)-3-morpholinopropan-2-ol DMLV0PQ MI TTR6W5O DMLV0PQ MN Adrenergic receptor beta-1 (ADRB1) DMLV0PQ MT DTT DMLV0PQ MA Inhibitor DMLV0PQ RN A vHTS approach for the identification of beta-adrenoceptor ligands. Bioorg Med Chem Lett. 2010 Jun 1;20(11):3399-404. DMLV0PQ RU https://pubmed.ncbi.nlm.nih.gov/20434333 DMLV0PQ DI DMLV0PQ DMLV0PQ DN 1-(2-allylphenoxy)-3-morpholinopropan-2-ol DMLV0PQ MI TT2CJVK DMLV0PQ MN Adrenergic receptor beta-2 (ADRB2) DMLV0PQ MT DTT DMLV0PQ MA Inhibitor DMLV0PQ RN A vHTS approach for the identification of beta-adrenoceptor ligands. Bioorg Med Chem Lett. 2010 Jun 1;20(11):3399-404. DMLV0PQ RU https://pubmed.ncbi.nlm.nih.gov/20434333 DMLV0PQ DI DMLV0PQ DMLV0PQ DN 1-(2-allylphenoxy)-3-morpholinopropan-2-ol DMLV0PQ MI TTMXGCW DMLV0PQ MN Adrenergic receptor beta-3 (ADRB3) DMLV0PQ MT DTT DMLV0PQ MA Inhibitor DMLV0PQ RN A vHTS approach for the identification of beta-adrenoceptor ligands. Bioorg Med Chem Lett. 2010 Jun 1;20(11):3399-404. DMLV0PQ RU https://pubmed.ncbi.nlm.nih.gov/20434333 DMAE8BF DI DMAE8BF DMAE8BF DN 1-(2-amino-benzothiazol-5-yl)-2-ethyl-isothiourea DMAE8BF MI TTZUFI5 DMAE8BF MN Nitric-oxide synthase brain (NOS1) DMAE8BF MT DTT DMAE8BF MA Inhibitor DMAE8BF RN Novel 2-aminobenzothiazoles as selective neuronal nitric oxide synthase inhibitors. Bioorg Med Chem Lett. 2007 May 1;17(9):2540-4. DMAE8BF RU https://pubmed.ncbi.nlm.nih.gov/17317165 DMAE8BF DI DMAE8BF DMAE8BF DN 1-(2-amino-benzothiazol-5-yl)-2-ethyl-isothiourea DMAE8BF MI TTCM4B3 DMAE8BF MN Nitric-oxide synthase endothelial (NOS3) DMAE8BF MT DTT DMAE8BF MA Inhibitor DMAE8BF RN Novel 2-aminobenzothiazoles as selective neuronal nitric oxide synthase inhibitors. Bioorg Med Chem Lett. 2007 May 1;17(9):2540-4. DMAE8BF RU https://pubmed.ncbi.nlm.nih.gov/17317165 DMCSHRL DI DMCSHRL DMCSHRL DN 1-(2-amino-benzothiazol-6-yl)-2-ethyl-isothiourea DMCSHRL MI TTZUFI5 DMCSHRL MN Nitric-oxide synthase brain (NOS1) DMCSHRL MT DTT DMCSHRL MA Inhibitor DMCSHRL RN Novel 2-aminobenzothiazoles as selective neuronal nitric oxide synthase inhibitors. Bioorg Med Chem Lett. 2007 May 1;17(9):2540-4. DMCSHRL RU https://pubmed.ncbi.nlm.nih.gov/17317165 DMCSHRL DI DMCSHRL DMCSHRL DN 1-(2-amino-benzothiazol-6-yl)-2-ethyl-isothiourea DMCSHRL MI TTCM4B3 DMCSHRL MN Nitric-oxide synthase endothelial (NOS3) DMCSHRL MT DTT DMCSHRL MA Inhibitor DMCSHRL RN Novel 2-aminobenzothiazoles as selective neuronal nitric oxide synthase inhibitors. Bioorg Med Chem Lett. 2007 May 1;17(9):2540-4. DMCSHRL RU https://pubmed.ncbi.nlm.nih.gov/17317165 DMKWO6A DI DMKWO6A DMKWO6A DN 1-(2-aminoethyl)-1H-indazol-6-ol DMKWO6A MI TTJQOD7 DMKWO6A MN 5-HT 2A receptor (HTR2A) DMKWO6A MT DTT DMKWO6A MA Inhibitor DMKWO6A RN 1-((S)-2-aminopropyl)-1H-indazol-6-ol: a potent peripherally acting 5-HT2 receptor agonist with ocular hypotensive activity. J Med Chem. 2006 Jan 12;49(1):318-28. DMKWO6A RU https://pubmed.ncbi.nlm.nih.gov/16392816 DMKWO6A DI DMKWO6A DMKWO6A DN 1-(2-aminoethyl)-1H-indazol-6-ol DMKWO6A MI TT0K1SC DMKWO6A MN 5-HT 2B receptor (HTR2B) DMKWO6A MT DTT DMKWO6A MA Inhibitor DMKWO6A RN 1-((S)-2-aminopropyl)-1H-indazol-6-ol: a potent peripherally acting 5-HT2 receptor agonist with ocular hypotensive activity. J Med Chem. 2006 Jan 12;49(1):318-28. DMKWO6A RU https://pubmed.ncbi.nlm.nih.gov/16392816 DMKWO6A DI DMKWO6A DMKWO6A DN 1-(2-aminoethyl)-1H-indazol-6-ol DMKWO6A MI TTWJBZ5 DMKWO6A MN 5-HT 2C receptor (HTR2C) DMKWO6A MT DTT DMKWO6A MA Inhibitor DMKWO6A RN 1-((S)-2-aminopropyl)-1H-indazol-6-ol: a potent peripherally acting 5-HT2 receptor agonist with ocular hypotensive activity. J Med Chem. 2006 Jan 12;49(1):318-28. DMKWO6A RU https://pubmed.ncbi.nlm.nih.gov/16392816 DMYF8ES DI DMYF8ES DMYF8ES DN 1-(2-bromoethyl)-1H-indole-2,3-dione DMYF8ES MI TTMF541 DMYF8ES MN Liver carboxylesterase (CES1) DMYF8ES MT DTT DMYF8ES MA Inhibitor DMYF8ES RN Selective inhibition of carboxylesterases by isatins, indole-2,3-diones. J Med Chem. 2007 Apr 19;50(8):1876-85. DMYF8ES RU https://pubmed.ncbi.nlm.nih.gov/17378546 DMUSEOW DI DMUSEOW DMUSEOW DN 1-(2-Bromo-phenyl)-3-(2,4-dihydroxy-phenyl)-urea DMUSEOW MI TTMWT8Z DMUSEOW MN C-X-C chemokine receptor type 1 (CXCR1) DMUSEOW MT DTT DMUSEOW MA Inhibitor DMUSEOW RN Synthesis and structure-activity relationships of 3,5-diarylisoxazoles and 3,5-diaryl-1,2,4-oxadiazoles, novel classes of small molecule interleuki... Bioorg Med Chem Lett. 2004 Aug 16;14(16):4307-11. DMUSEOW RU https://pubmed.ncbi.nlm.nih.gov/15261292 DMU9T3A DI DMU9T3A DMU9T3A DN 1-(2-bromophenyl)-3-(4-cyano-2-hydroxyphenyl)urea DMU9T3A MI TT30C9G DMU9T3A MN C-X-C chemokine receptor type 2 (CXCR2) DMU9T3A MT DTT DMU9T3A MA Inhibitor DMU9T3A RN Comparison of N,N'-diarylsquaramides and N,N'-diarylureas as antagonists of the CXCR2 chemokine receptor. Bioorg Med Chem Lett. 2007 Mar 15;17(6):1713-7. DMU9T3A RU https://pubmed.ncbi.nlm.nih.gov/17236763 DMT5S2O DI DMT5S2O DMT5S2O DN 1-(2-Butoxy-phenyl)-piperazine DMT5S2O MI TTSQIFT DMT5S2O MN 5-HT 1A receptor (HTR1A) DMT5S2O MT DTT DMT5S2O MA Inhibitor DMT5S2O RN Activity of aromatic substituted phenylpiperazines lacking affinity for dopamine binding sites in a preclinical test of antipsychotic efficacy. J Med Chem. 1989 May;32(5):1052-6. DMT5S2O RU https://pubmed.ncbi.nlm.nih.gov/2565400 DMT5S2O DI DMT5S2O DMT5S2O DN 1-(2-Butoxy-phenyl)-piperazine DMT5S2O MI TT6MSOK DMT5S2O MN 5-HT 1D receptor (HTR1D) DMT5S2O MT DTT DMT5S2O MA Inhibitor DMT5S2O RN Activity of aromatic substituted phenylpiperazines lacking affinity for dopamine binding sites in a preclinical test of antipsychotic efficacy. J Med Chem. 1989 May;32(5):1052-6. DMT5S2O RU https://pubmed.ncbi.nlm.nih.gov/2565400 DMGSKAO DI DMGSKAO DMGSKAO DN 1-(2-chlorophenyl)-3-(pyridin-2-yl)thiourea DMGSKAO MI TT6804T DMGSKAO MN MIF messenger RNA (MIF mRNA) DMGSKAO MT DTT DMGSKAO MA Inhibitor DMGSKAO RN An integrative in silico methodology for the identification of modulators of macrophage migration inhibitory factor (MIF) tautomerase activity. Bioorg Med Chem. 2010 Jul 15;18(14):5425-40. DMGSKAO RU https://pubmed.ncbi.nlm.nih.gov/20639113 DMKTZSY DI DMKTZSY DMKTZSY DN 1-(2'-chlorophenyl)penta-1,4-dien-3-one DMKTZSY MI TTEP6RV DMKTZSY MN Glutathione reductase (GR) DMKTZSY MT DTT DMKTZSY MA Inhibitor DMKTZSY RN Irreversible inactivation of trypanothione reductase by unsaturated Mannich bases: a divinyl ketone as key intermediate. J Med Chem. 2005 Nov 17;48(23):7400-10. DMKTZSY RU https://pubmed.ncbi.nlm.nih.gov/16279799 DMKTZSY DI DMKTZSY DMKTZSY DN 1-(2'-chlorophenyl)penta-1,4-dien-3-one DMKTZSY MI TTRTKPV DMKTZSY MN Trypanosoma Trypanothione reductase (Trypano TPR) DMKTZSY MT DTT DMKTZSY MA Inhibitor DMKTZSY RN Irreversible inactivation of trypanothione reductase by unsaturated Mannich bases: a divinyl ketone as key intermediate. J Med Chem. 2005 Nov 17;48(23):7400-10. DMKTZSY RU https://pubmed.ncbi.nlm.nih.gov/16279799 DM5RE71 DI DM5RE71 DM5RE71 DN 1-(2-Chloro-phenyl)-piperazine DM5RE71 MI TTSQIFT DM5RE71 MN 5-HT 1A receptor (HTR1A) DM5RE71 MT DTT DM5RE71 MA Inhibitor DM5RE71 RN Pyrimido[5,4-b]indole derivatives. 1. A new class of potent and selective alpha 1 adrenoceptor ligands. J Med Chem. 1991 Jun;34(6):1850-4. DM5RE71 RU https://pubmed.ncbi.nlm.nih.gov/1648138 DM5RE71 DI DM5RE71 DM5RE71 DN 1-(2-Chloro-phenyl)-piperazine DM5RE71 MI TTNGILX DM5RE71 MN Adrenergic receptor alpha-1A (ADRA1A) DM5RE71 MT DTT DM5RE71 MA Inhibitor DM5RE71 RN Pyrimido[5,4-b]indole derivatives. 1. A new class of potent and selective alpha 1 adrenoceptor ligands. J Med Chem. 1991 Jun;34(6):1850-4. DM5RE71 RU https://pubmed.ncbi.nlm.nih.gov/1648138 DM5RE71 DI DM5RE71 DM5RE71 DN 1-(2-Chloro-phenyl)-piperazine DM5RE71 MI TT34BHT DM5RE71 MN Adrenergic receptor alpha-1D (ADRA1D) DM5RE71 MT DTT DM5RE71 MA Inhibitor DM5RE71 RN Pyrimido[5,4-b]indole derivatives. 1. A new class of potent and selective alpha 1 adrenoceptor ligands. J Med Chem. 1991 Jun;34(6):1850-4. DM5RE71 RU https://pubmed.ncbi.nlm.nih.gov/1648138 DMM3LET DI DMM3LET DMM3LET DN 1-(2-Dimethylamino-ethyl)-1H-indol-4-ol DMM3LET MI TTWJBZ5 DMM3LET MN 5-HT 2C receptor (HTR2C) DMM3LET MT DTT DMM3LET MA Inhibitor DMM3LET RN SAR of psilocybin analogs: discovery of a selective 5-HT 2C agonist. Bioorg Med Chem Lett. 2005 Oct 15;15(20):4555-9. DMM3LET RU https://pubmed.ncbi.nlm.nih.gov/16061378 DMV3FSH DI DMV3FSH DMV3FSH DN 1-(2-ethoxy-1-phenylethyl)-4-phenylpiperidin-4-ol DMV3FSH MI TTNT7K8 DMV3FSH MN Nociceptin receptor (OPRL1) DMV3FSH MT DTT DMV3FSH MA Inhibitor DMV3FSH RN Bioorg Med Chem Lett. 2007 Jun 1;17(11):3023-7. Epub 2007 Mar 23.Synthesis and structure-activity relationships of 4-hydroxy-4-phenylpiperidines as nociceptin receptor ligands: Part 1. DMV3FSH RU https://pubmed.ncbi.nlm.nih.gov/17428659 DMV3FSH DI DMV3FSH DMV3FSH DN 1-(2-ethoxy-1-phenylethyl)-4-phenylpiperidin-4-ol DMV3FSH MI TT27RFC DMV3FSH MN Opioid receptor delta (OPRD1) DMV3FSH MT DTT DMV3FSH MA Inhibitor DMV3FSH RN Bioorg Med Chem Lett. 2007 Jun 1;17(11):3023-7. Epub 2007 Mar 23.Synthesis and structure-activity relationships of 4-hydroxy-4-phenylpiperidines as nociceptin receptor ligands: Part 1. DMV3FSH RU https://pubmed.ncbi.nlm.nih.gov/17428659 DMV3FSH DI DMV3FSH DMV3FSH DN 1-(2-ethoxy-1-phenylethyl)-4-phenylpiperidin-4-ol DMV3FSH MI TTQW87Y DMV3FSH MN Opioid receptor kappa (OPRK1) DMV3FSH MT DTT DMV3FSH MA Inhibitor DMV3FSH RN Bioorg Med Chem Lett. 2007 Jun 1;17(11):3023-7. Epub 2007 Mar 23.Synthesis and structure-activity relationships of 4-hydroxy-4-phenylpiperidines as nociceptin receptor ligands: Part 1. DMV3FSH RU https://pubmed.ncbi.nlm.nih.gov/17428659 DMV3FSH DI DMV3FSH DMV3FSH DN 1-(2-ethoxy-1-phenylethyl)-4-phenylpiperidin-4-ol DMV3FSH MI TTKWM86 DMV3FSH MN Opioid receptor mu (MOP) DMV3FSH MT DTT DMV3FSH MA Inhibitor DMV3FSH RN Bioorg Med Chem Lett. 2007 Jun 1;17(11):3023-7. Epub 2007 Mar 23.Synthesis and structure-activity relationships of 4-hydroxy-4-phenylpiperidines as nociceptin receptor ligands: Part 1. DMV3FSH RU https://pubmed.ncbi.nlm.nih.gov/17428659 DM2P7YX DI DM2P7YX DM2P7YX DN 1-(2-Ethoxy-phenyl)-piperazine DM2P7YX MI TTSQIFT DM2P7YX MN 5-HT 1A receptor (HTR1A) DM2P7YX MT DTT DM2P7YX MA Inhibitor DM2P7YX RN Activity of aromatic substituted phenylpiperazines lacking affinity for dopamine binding sites in a preclinical test of antipsychotic efficacy. J Med Chem. 1989 May;32(5):1052-6. DM2P7YX RU https://pubmed.ncbi.nlm.nih.gov/2565400 DM2P7YX DI DM2P7YX DM2P7YX DN 1-(2-Ethoxy-phenyl)-piperazine DM2P7YX MI TT6MSOK DM2P7YX MN 5-HT 1D receptor (HTR1D) DM2P7YX MT DTT DM2P7YX MA Inhibitor DM2P7YX RN Activity of aromatic substituted phenylpiperazines lacking affinity for dopamine binding sites in a preclinical test of antipsychotic efficacy. J Med Chem. 1989 May;32(5):1052-6. DM2P7YX RU https://pubmed.ncbi.nlm.nih.gov/2565400 DM94LID DI DM94LID DM94LID DN 1-(2-Fluoro-phenyl)-piperazine DM94LID MI TTSQIFT DM94LID MN 5-HT 1A receptor (HTR1A) DM94LID MT DTT DM94LID MA Inhibitor DM94LID RN Activity of aromatic substituted phenylpiperazines lacking affinity for dopamine binding sites in a preclinical test of antipsychotic efficacy. J Med Chem. 1989 May;32(5):1052-6. DM94LID RU https://pubmed.ncbi.nlm.nih.gov/2565400 DM94LID DI DM94LID DM94LID DN 1-(2-Fluoro-phenyl)-piperazine DM94LID MI TT6MSOK DM94LID MN 5-HT 1D receptor (HTR1D) DM94LID MT DTT DM94LID MA Inhibitor DM94LID RN Activity of aromatic substituted phenylpiperazines lacking affinity for dopamine binding sites in a preclinical test of antipsychotic efficacy. J Med Chem. 1989 May;32(5):1052-6. DM94LID RU https://pubmed.ncbi.nlm.nih.gov/2565400 DM0K2T1 DI DM0K2T1 DM0K2T1 DN 1-(2-Furan-2-yl-ethyl)-3-thiazol-2-yl-thiourea DM0K2T1 MI TT84ETX DM0K2T1 MN Human immunodeficiency virus Reverse transcriptase (HIV RT) DM0K2T1 MT DTT DM0K2T1 MA Inhibitor DM0K2T1 RN Phenethylthiazolethiourea (PETT) compounds, a new class of HIV-1 reverse transcriptase inhibitors. 1. Synthesis and basic structure-activity relati... J Med Chem. 1995 Dec 8;38(25):4929-36. DM0K2T1 RU https://pubmed.ncbi.nlm.nih.gov/8523406 DM3WXET DI DM3WXET DM3WXET DN 1-(2-Hydroxy-3-nitro-phenyl)-3-phenyl-urea DM3WXET MI TT30C9G DM3WXET MN C-X-C chemokine receptor type 2 (CXCR2) DM3WXET MT DTT DM3WXET MA Inhibitor DM3WXET RN Evaluation of potent and selective small-molecule antagonists for the CXCR2 chemokine receptor. J Med Chem. 2004 Mar 11;47(6):1319-21. DM3WXET RU https://pubmed.ncbi.nlm.nih.gov/14998320 DMN4G7U DI DMN4G7U DMN4G7U DN 1-(2-hydroxy-4-nitrophenyl)-3-phenylurea DMN4G7U MI TTMWT8Z DMN4G7U MN C-X-C chemokine receptor type 1 (CXCR1) DMN4G7U MT DTT DMN4G7U MA Inhibitor DMN4G7U RN Evaluation of potent and selective small-molecule antagonists for the CXCR2 chemokine receptor. J Med Chem. 2004 Mar 11;47(6):1319-21. DMN4G7U RU https://pubmed.ncbi.nlm.nih.gov/14998320 DMN4G7U DI DMN4G7U DMN4G7U DN 1-(2-hydroxy-4-nitrophenyl)-3-phenylurea DMN4G7U MI TT30C9G DMN4G7U MN C-X-C chemokine receptor type 2 (CXCR2) DMN4G7U MT DTT DMN4G7U MA Inhibitor DMN4G7U RN Identification of a potent, selective non-peptide CXCR2 antagonist that inhibits interleukin-8-induced neutrophil migration. J Biol Chem. 1998 Apr 24;273(17):10095-8. DMN4G7U RU https://pubmed.ncbi.nlm.nih.gov/9553055 DMPLHEY DI DMPLHEY DMPLHEY DN 1-(2-Hydroxy-5-nitro-phenyl)-3-phenyl-urea DMPLHEY MI TT30C9G DMPLHEY MN C-X-C chemokine receptor type 2 (CXCR2) DMPLHEY MT DTT DMPLHEY MA Inhibitor DMPLHEY RN Evaluation of potent and selective small-molecule antagonists for the CXCR2 chemokine receptor. J Med Chem. 2004 Mar 11;47(6):1319-21. DMPLHEY RU https://pubmed.ncbi.nlm.nih.gov/14998320 DMAFS7J DI DMAFS7J DMAFS7J DN 1-(2-hydroxyphenyl)-3-p-tolylprop-2-en-1-one DMAFS7J MI TTVKILB DMAFS7J MN Prostaglandin G/H synthase 2 (COX-2) DMAFS7J MT DTT DMAFS7J MA Inhibitor DMAFS7J RN Inhibitory activity of prostaglandin E2 production by the synthetic 2'-hydroxychalcone analogues: Synthesis and SAR study. Bioorg Med Chem Lett. 2009 Mar 15;19(6):1650-3. DMAFS7J RU https://pubmed.ncbi.nlm.nih.gov/19233646 DM1MSAC DI DM1MSAC DM1MSAC DN 1-(2-iodoethyl)-1H-indole-2,3-dione DM1MSAC MI TTMF541 DM1MSAC MN Liver carboxylesterase (CES1) DM1MSAC MT DTT DM1MSAC MA Inhibitor DM1MSAC RN Selective inhibition of carboxylesterases by isatins, indole-2,3-diones. J Med Chem. 2007 Apr 19;50(8):1876-85. DM1MSAC RU https://pubmed.ncbi.nlm.nih.gov/17378546 DM5KAH6 DI DM5KAH6 DM5KAH6 DN 1-(2-Isopropoxy-phenyl)-piperazine DM5KAH6 MI TTSQIFT DM5KAH6 MN 5-HT 1A receptor (HTR1A) DM5KAH6 MT DTT DM5KAH6 MA Inhibitor DM5KAH6 RN Activity of aromatic substituted phenylpiperazines lacking affinity for dopamine binding sites in a preclinical test of antipsychotic efficacy. J Med Chem. 1989 May;32(5):1052-6. DM5KAH6 RU https://pubmed.ncbi.nlm.nih.gov/2565400 DM5KAH6 DI DM5KAH6 DM5KAH6 DN 1-(2-Isopropoxy-phenyl)-piperazine DM5KAH6 MI TT6MSOK DM5KAH6 MN 5-HT 1D receptor (HTR1D) DM5KAH6 MT DTT DM5KAH6 MA Inhibitor DM5KAH6 RN Activity of aromatic substituted phenylpiperazines lacking affinity for dopamine binding sites in a preclinical test of antipsychotic efficacy. J Med Chem. 1989 May;32(5):1052-6. DM5KAH6 RU https://pubmed.ncbi.nlm.nih.gov/2565400 DMK209P DI DMK209P DMK209P DN 1-(2-isopropylphenoxy)-3-morpholinopropan-2-ol DMK209P MI TTR6W5O DMK209P MN Adrenergic receptor beta-1 (ADRB1) DMK209P MT DTT DMK209P MA Inhibitor DMK209P RN A vHTS approach for the identification of beta-adrenoceptor ligands. Bioorg Med Chem Lett. 2010 Jun 1;20(11):3399-404. DMK209P RU https://pubmed.ncbi.nlm.nih.gov/20434333 DMK209P DI DMK209P DMK209P DN 1-(2-isopropylphenoxy)-3-morpholinopropan-2-ol DMK209P MI TT2CJVK DMK209P MN Adrenergic receptor beta-2 (ADRB2) DMK209P MT DTT DMK209P MA Inhibitor DMK209P RN A vHTS approach for the identification of beta-adrenoceptor ligands. Bioorg Med Chem Lett. 2010 Jun 1;20(11):3399-404. DMK209P RU https://pubmed.ncbi.nlm.nih.gov/20434333 DMK209P DI DMK209P DMK209P DN 1-(2-isopropylphenoxy)-3-morpholinopropan-2-ol DMK209P MI TTMXGCW DMK209P MN Adrenergic receptor beta-3 (ADRB3) DMK209P MT DTT DMK209P MA Inhibitor DMK209P RN A vHTS approach for the identification of beta-adrenoceptor ligands. Bioorg Med Chem Lett. 2010 Jun 1;20(11):3399-404. DMK209P RU https://pubmed.ncbi.nlm.nih.gov/20434333 DMIPAMW DI DMIPAMW DMIPAMW DN 1-(2-mercaptoethyl)-3-(m-tolylsulfonyl)urea DMIPAMW MI TTWHDVK DMIPAMW MN Fructose-1,6-bisphosphatase (FBP) DMIPAMW MT DTT DMIPAMW MA Inhibitor DMIPAMW RN Allosteric FBPase inhibitors gain 10(5) times in potency when simultaneously binding two neighboring AMP sites. Bioorg Med Chem Lett. 2008 Aug 15;18(16):4708-12. DMIPAMW RU https://pubmed.ncbi.nlm.nih.gov/18650089 DMDQVSU DI DMDQVSU DMDQVSU DN 1-(2-methoxyphenethyl)pyrrolidine DMDQVSU MI TT9JNIC DMDQVSU MN Histamine H3 receptor (H3R) DMDQVSU MT DTT DMDQVSU MA Inhibitor DMDQVSU RN In vitro SAR of pyrrolidine-containing histamine H3 receptor antagonists: trends across multiple chemical series. Bioorg Med Chem Lett. 2008 Jan 1;18(1):355-9. DMDQVSU RU https://pubmed.ncbi.nlm.nih.gov/18077160 DM0EZSR DI DM0EZSR DM0EZSR DN 1-(2-methoxyphenyl)-4-pentylpiperazine DM0EZSR MI TTSQIFT DM0EZSR MN 5-HT 1A receptor (HTR1A) DM0EZSR MT DTT DM0EZSR MA Inhibitor DM0EZSR RN Identification of a red-emitting fluorescent ligand for in vitro visualization of human serotonin 5-HT(1A) receptors. Bioorg Med Chem Lett. 2010 Nov 15;20(22):6628-32. DM0EZSR RU https://pubmed.ncbi.nlm.nih.gov/20888762 DMCADRI DI DMCADRI DMCADRI DN 1-(2-Methoxy-phenyl)-4-propyl-piperazine DMCADRI MI TTSQIFT DMCADRI MN 5-HT 1A receptor (HTR1A) DMCADRI MT DTT DMCADRI MA Inhibitor DMCADRI RN Structure-activity relationship studies of central nervous system agents. 13. 4-[3-(Benzotriazol-1-yl)propyl]-1-(2-methoxyphenyl)piperazine, a new ... J Med Chem. 1994 Aug 19;37(17):2754-60. DMCADRI RU https://pubmed.ncbi.nlm.nih.gov/8064802 DMCADRI DI DMCADRI DMCADRI DN 1-(2-Methoxy-phenyl)-4-propyl-piperazine DMCADRI MI TTJQOD7 DMCADRI MN 5-HT 2A receptor (HTR2A) DMCADRI MT DTT DMCADRI MA Inhibitor DMCADRI RN Structure-activity relationship studies of central nervous system agents. 13. 4-[3-(Benzotriazol-1-yl)propyl]-1-(2-methoxyphenyl)piperazine, a new ... J Med Chem. 1994 Aug 19;37(17):2754-60. DMCADRI RU https://pubmed.ncbi.nlm.nih.gov/8064802 DM3M4RA DI DM3M4RA DM3M4RA DN 1-(2-Methoxy-phenyl)-piperazine DM3M4RA MI TTSQIFT DM3M4RA MN 5-HT 1A receptor (HTR1A) DM3M4RA MT DTT DM3M4RA MA Inhibitor DM3M4RA RN Pyrimido[5,4-b]indole derivatives. 1. A new class of potent and selective alpha 1 adrenoceptor ligands. J Med Chem. 1991 Jun;34(6):1850-4. DM3M4RA RU https://pubmed.ncbi.nlm.nih.gov/1648138 DM3M4RA DI DM3M4RA DM3M4RA DN 1-(2-Methoxy-phenyl)-piperazine DM3M4RA MI TT6MSOK DM3M4RA MN 5-HT 1D receptor (HTR1D) DM3M4RA MT DTT DM3M4RA MA Inhibitor DM3M4RA RN Activity of aromatic substituted phenylpiperazines lacking affinity for dopamine binding sites in a preclinical test of antipsychotic efficacy. J Med Chem. 1989 May;32(5):1052-6. DM3M4RA RU https://pubmed.ncbi.nlm.nih.gov/2565400 DM3M4RA DI DM3M4RA DM3M4RA DN 1-(2-Methoxy-phenyl)-piperazine DM3M4RA MI TTJQOD7 DM3M4RA MN 5-HT 2A receptor (HTR2A) DM3M4RA MT DTT DM3M4RA MA Inhibitor DM3M4RA RN Synthesis and evaluation of phenyl- and benzoylpiperazines as potential serotonergic agents. J Med Chem. 1986 May;29(5):630-4. DM3M4RA RU https://pubmed.ncbi.nlm.nih.gov/3701781 DM3M4RA DI DM3M4RA DM3M4RA DN 1-(2-Methoxy-phenyl)-piperazine DM3M4RA MI TTJS8PY DM3M4RA MN 5-HT 6 receptor (HTR6) DM3M4RA MT DTT DM3M4RA MA Inhibitor DM3M4RA RN 1-(1-Naphthyl)piperazine as a novel template for 5-HT6 serotonin receptor ligands. Bioorg Med Chem Lett. 2005 Mar 15;15(6):1707-11. DM3M4RA RU https://pubmed.ncbi.nlm.nih.gov/15745826 DM3M4RA DI DM3M4RA DM3M4RA DN 1-(2-Methoxy-phenyl)-piperazine DM3M4RA MI TTO9X1H DM3M4RA MN 5-HT 7 receptor (HTR7) DM3M4RA MT DTT DM3M4RA MA Agonist DM3M4RA RN Molecular cloning and expression of a 5-hydroxytryptamine7 serotonin receptor subtype. J Biol Chem. 1993 Aug 25;268(24):18200-4. DM3M4RA RU https://pubmed.ncbi.nlm.nih.gov/8394362 DM3M4RA DI DM3M4RA DM3M4RA DN 1-(2-Methoxy-phenyl)-piperazine DM3M4RA MI TTNGILX DM3M4RA MN Adrenergic receptor alpha-1A (ADRA1A) DM3M4RA MT DTT DM3M4RA MA Inhibitor DM3M4RA RN Pyrimido[5,4-b]indole derivatives. 1. A new class of potent and selective alpha 1 adrenoceptor ligands. J Med Chem. 1991 Jun;34(6):1850-4. DM3M4RA RU https://pubmed.ncbi.nlm.nih.gov/1648138 DM3M4RA DI DM3M4RA DM3M4RA DN 1-(2-Methoxy-phenyl)-piperazine DM3M4RA MI TT34BHT DM3M4RA MN Adrenergic receptor alpha-1D (ADRA1D) DM3M4RA MT DTT DM3M4RA MA Inhibitor DM3M4RA RN Pyrimido[5,4-b]indole derivatives. 1. A new class of potent and selective alpha 1 adrenoceptor ligands. J Med Chem. 1991 Jun;34(6):1850-4. DM3M4RA RU https://pubmed.ncbi.nlm.nih.gov/1648138 DMBWCOZ DI DMBWCOZ DMBWCOZ DN 1-(2-methylphenyl)-2-pyrrolidin-1-yl-pentan-1-one DMBWCOZ MI TTVBI8W DMBWCOZ MN Dopamine transporter (DAT) DMBWCOZ MT DTT DMBWCOZ MA Inhibitor DMBWCOZ RN 1-(4-Methylphenyl)-2-pyrrolidin-1-yl-pentan-1-one (Pyrovalerone) analogues: a promising class of monoamine uptake inhibitors. J Med Chem. 2006 Feb 23;49(4):1420-32. DMBWCOZ RU https://pubmed.ncbi.nlm.nih.gov/16480278 DMBWCOZ DI DMBWCOZ DMBWCOZ DN 1-(2-methylphenyl)-2-pyrrolidin-1-yl-pentan-1-one DMBWCOZ MI TTAWNKZ DMBWCOZ MN Norepinephrine transporter (NET) DMBWCOZ MT DTT DMBWCOZ MA Inhibitor DMBWCOZ RN 1-(4-Methylphenyl)-2-pyrrolidin-1-yl-pentan-1-one (Pyrovalerone) analogues: a promising class of monoamine uptake inhibitors. J Med Chem. 2006 Feb 23;49(4):1420-32. DMBWCOZ RU https://pubmed.ncbi.nlm.nih.gov/16480278 DMBWCOZ DI DMBWCOZ DMBWCOZ DN 1-(2-methylphenyl)-2-pyrrolidin-1-yl-pentan-1-one DMBWCOZ MI TT3ROYC DMBWCOZ MN Serotonin transporter (SERT) DMBWCOZ MT DTT DMBWCOZ MA Inhibitor DMBWCOZ RN 1-(4-Methylphenyl)-2-pyrrolidin-1-yl-pentan-1-one (Pyrovalerone) analogues: a promising class of monoamine uptake inhibitors. J Med Chem. 2006 Feb 23;49(4):1420-32. DMBWCOZ RU https://pubmed.ncbi.nlm.nih.gov/16480278 DMZF0D3 DI DMZF0D3 DMZF0D3 DN 1-(2-morpholinoethyl)-1H-indol-3-yl acetate DMZF0D3 MI TT6OEDT DMZF0D3 MN Cannabinoid receptor 1 (CB1) DMZF0D3 MT DTT DMZF0D3 MA Inhibitor DMZF0D3 RN Synthesis and cannabinoid activity of 1-substituted-indole-3-oxadiazole derivatives: novel agonists for the CB1 receptor. Eur J Med Chem. 2008 Mar;43(3):513-39. DMZF0D3 RU https://pubmed.ncbi.nlm.nih.gov/17582659 DMKITY6 DI DMKITY6 DMKITY6 DN 1-(2-m-tolyl-ethyl)-pyrrolidine DMKITY6 MI TT9JNIC DMKITY6 MN Histamine H3 receptor (H3R) DMKITY6 MT DTT DMKITY6 MA Inhibitor DMKITY6 RN In vitro SAR of pyrrolidine-containing histamine H3 receptor antagonists: trends across multiple chemical series. Bioorg Med Chem Lett. 2008 Jan 1;18(1):355-9. DMKITY6 RU https://pubmed.ncbi.nlm.nih.gov/18077160 DMBNZKH DI DMBNZKH DMBNZKH DN 1-(2-Naphthyl)-2-aminopropane DMBNZKH MI TT3WG5C DMBNZKH MN Monoamine oxidase type A (MAO-A) DMBNZKH MT DTT DMBNZKH MA Inhibitor DMBNZKH RN Naphthylisopropylamine and N-benzylamphetamine derivatives as monoamine oxidase inhibitors. Bioorg Med Chem. 2009 Mar 15;17(6):2452-60. DMBNZKH RU https://pubmed.ncbi.nlm.nih.gov/19243954 DMR12KP DI DMR12KP DMR12KP DN 1-(2-nitrophenethyl)-1H-pyrrolo[3,2-b]pyridine DMR12KP MI TTNDSF4 DMR12KP MN Proto-oncogene c-Met (MET) DMR12KP MT DTT DMR12KP MA Inhibitor DMR12KP RN Discovery of 4-azaindoles as novel inhibitors of c-Met kinase. Bioorg Med Chem Lett. 2009 May 15;19(10):2780-4. DMR12KP RU https://pubmed.ncbi.nlm.nih.gov/19369077 DM69T3A DI DM69T3A DM69T3A DN 1-(2-Oxo-2-p-tolyl-ethyl)-1H-indole-2,3-dione DM69T3A MI TTP86E2 DM69T3A MN Plasminogen (PLG) DM69T3A MT DTT DM69T3A MA Inhibitor DM69T3A RN Parallel synthesis of isatin-based serine protease inhibitors. Bioorg Med Chem Lett. 2000 Nov 20;10(22):2501-4. DM69T3A RU https://pubmed.ncbi.nlm.nih.gov/11086715 DMLY4ER DI DMLY4ER DMLY4ER DN 1-(2-phenoxybenzyl)-1H-imidazole DMLY4ER MI TTSZLWK DMLY4ER MN Aromatase (CYP19A1) DMLY4ER MT DTT DMLY4ER MA Inhibitor DMLY4ER RN Novel highly potent and selective nonsteroidal aromatase inhibitors: synthesis, biological evaluation and structure-activity relationships investigation. J Med Chem. 2010 Jul 22;53(14):5347-51. DMLY4ER RU https://pubmed.ncbi.nlm.nih.gov/20568782 DMOMAXJ DI DMOMAXJ DMOMAXJ DN 1-(2-Phenoxy-ethyl)-1H-imidazole DMOMAXJ MI TTIQUX7 DMOMAXJ MN Steroid 11-beta-hydroxylase (CYP11B1) DMOMAXJ MT DTT DMOMAXJ MA Inhibitor DMOMAXJ RN Selective thromboxane synthetase inhibitors. 1. 1-[(Aryloxy)alkyl]-1H-imidazoles. J Med Chem. 1985 Oct;28(10):1427-32. DMOMAXJ RU https://pubmed.ncbi.nlm.nih.gov/3930740 DMC1IKP DI DMC1IKP DMC1IKP DN 1-(2-Phenoxy-ethyl)-3-thiazol-2-yl-thiourea DMC1IKP MI TT84ETX DMC1IKP MN Human immunodeficiency virus Reverse transcriptase (HIV RT) DMC1IKP MT DTT DMC1IKP MA Inhibitor DMC1IKP RN Anti-HIV activity of aromatic and heterocyclic thiazolyl thiourea compounds. Bioorg Med Chem Lett. 2001 Feb 26;11(4):523-8. DMC1IKP RU https://pubmed.ncbi.nlm.nih.gov/11229762 DMWFCYN DI DMWFCYN DMWFCYN DN 1-(2-phenoxyphenyl)piperazine DMWFCYN MI TTSQIFT DMWFCYN MN 5-HT 1A receptor (HTR1A) DMWFCYN MT DTT DMWFCYN MA Inhibitor DMWFCYN RN Discovery and pharmacological characterization of aryl piperazine and piperidine ethers as dual acting norepinephrine reuptake inhibitors and 5-HT1... Bioorg Med Chem Lett. 2009 Dec 1;19(23):6604-7. DMWFCYN RU https://pubmed.ncbi.nlm.nih.gov/19854053 DMWFCYN DI DMWFCYN DMWFCYN DN 1-(2-phenoxyphenyl)piperazine DMWFCYN MI TTVBI8W DMWFCYN MN Dopamine transporter (DAT) DMWFCYN MT DTT DMWFCYN MA Inhibitor DMWFCYN RN Discovery and pharmacological characterization of aryl piperazine and piperidine ethers as dual acting norepinephrine reuptake inhibitors and 5-HT1... Bioorg Med Chem Lett. 2009 Dec 1;19(23):6604-7. DMWFCYN RU https://pubmed.ncbi.nlm.nih.gov/19854053 DMWFCYN DI DMWFCYN DMWFCYN DN 1-(2-phenoxyphenyl)piperazine DMWFCYN MI TTAWNKZ DMWFCYN MN Norepinephrine transporter (NET) DMWFCYN MT DTT DMWFCYN MA Inhibitor DMWFCYN RN Discovery and pharmacological characterization of aryl piperazine and piperidine ethers as dual acting norepinephrine reuptake inhibitors and 5-HT1... Bioorg Med Chem Lett. 2009 Dec 1;19(23):6604-7. DMWFCYN RU https://pubmed.ncbi.nlm.nih.gov/19854053 DMWFCYN DI DMWFCYN DMWFCYN DN 1-(2-phenoxyphenyl)piperazine DMWFCYN MI TT3ROYC DMWFCYN MN Serotonin transporter (SERT) DMWFCYN MT DTT DMWFCYN MA Inhibitor DMWFCYN RN Discovery and pharmacological characterization of aryl piperazine and piperidine ethers as dual acting norepinephrine reuptake inhibitors and 5-HT1... Bioorg Med Chem Lett. 2009 Dec 1;19(23):6604-7. DMWFCYN RU https://pubmed.ncbi.nlm.nih.gov/19854053 DMXG10E DI DMXG10E DMXG10E DN 1-(2-Phenyl-propyl)-3-thiazol-2-yl-thiourea DMXG10E MI TT84ETX DMXG10E MN Human immunodeficiency virus Reverse transcriptase (HIV RT) DMXG10E MT DTT DMXG10E MA Inhibitor DMXG10E RN Phenethylthiazolethiourea (PETT) compounds, a new class of HIV-1 reverse transcriptase inhibitors. 1. Synthesis and basic structure-activity relati... J Med Chem. 1995 Dec 8;38(25):4929-36. DMXG10E RU https://pubmed.ncbi.nlm.nih.gov/8523406 DMDLKPI DI DMDLKPI DMDLKPI DN 1-(2-p-tolyl-ethyl)-pyrrolidine DMDLKPI MI TT9JNIC DMDLKPI MN Histamine H3 receptor (H3R) DMDLKPI MT DTT DMDLKPI MA Inhibitor DMDLKPI RN In vitro SAR of pyrrolidine-containing histamine H3 receptor antagonists: trends across multiple chemical series. Bioorg Med Chem Lett. 2008 Jan 1;18(1):355-9. DMDLKPI RU https://pubmed.ncbi.nlm.nih.gov/18077160 DM4B2EN DI DM4B2EN DM4B2EN DN 1-(2-Pyridin-2-yl-ethyl)-3-thiazol-2-yl-thiourea DM4B2EN MI TT84ETX DM4B2EN MN Human immunodeficiency virus Reverse transcriptase (HIV RT) DM4B2EN MT DTT DM4B2EN MA Inhibitor DM4B2EN RN Phenethylthiazolethiourea (PETT) compounds, a new class of HIV-1 reverse transcriptase inhibitors. 1. Synthesis and basic structure-activity relati... J Med Chem. 1995 Dec 8;38(25):4929-36. DM4B2EN RU https://pubmed.ncbi.nlm.nih.gov/8523406 DMEDSLZ DI DMEDSLZ DMEDSLZ DN 1-(3-(2-(3-methoxyphenoxy)ethoxy)propyl)azepane DMEDSLZ MI TT9JNIC DMEDSLZ MN Histamine H3 receptor (H3R) DMEDSLZ MT DTT DMEDSLZ MA Inhibitor DMEDSLZ RN Diether derivatives of homo- or substituted piperidines as non-imidazole histamine H3 receptor ligands. Bioorg Med Chem. 2009 Apr 15;17(8):3037-42. DMEDSLZ RU https://pubmed.ncbi.nlm.nih.gov/19329325 DMD25N9 DI DMD25N9 DMD25N9 DN 1-(3-(2-methylquinolin-7-yl)phenyl)ethanone DMD25N9 MI TTHS256 DMD25N9 MN Metabotropic glutamate receptor 5 (mGluR5) DMD25N9 MT DTT DMD25N9 MA Inhibitor DMD25N9 RN Rational design of 7-arylquinolines as non-competitive metabotropic glutamate receptor subtype 5 antagonists. Bioorg Med Chem Lett. 2007 Aug 15;17(16):4415-8. DMD25N9 RU https://pubmed.ncbi.nlm.nih.gov/17590335 DM3EBFS DI DM3EBFS DM3EBFS DN 1-(3-(3-morpholinopropoxy)phenyl)-3-phenylurea DM3EBFS MI TT7WVHI DM3EBFS MN Soluble epoxide hydrolase (EPHX2) DM3EBFS MT DTT DM3EBFS MA Inhibitor DM3EBFS RN Unsymmetrical non-adamantyl N,N'-diaryl urea and amide inhibitors of soluble expoxide hydrolase. Bioorg Med Chem Lett. 2009 Aug 1;19(15):4259-63. DM3EBFS RU https://pubmed.ncbi.nlm.nih.gov/19520575 DM3EYOL DI DM3EYOL DM3EYOL DN 1-(3-(3-phenylpropoxy)propyl)piperidine DM3EYOL MI TT9JNIC DM3EYOL MN Histamine H3 receptor (H3R) DM3EYOL MT DTT DM3EYOL MA Inhibitor DM3EYOL RN Piperidine variations in search for non-imidazole histamine H(3) receptor ligands. Bioorg Med Chem. 2008 Sep 15;16(18):8729-36. DM3EYOL RU https://pubmed.ncbi.nlm.nih.gov/18774720 DMHEIKQ DI DMHEIKQ DMHEIKQ DN 1-(3-(4-(2-fluoroethyl)phenoxy)propyl)piperidine DMHEIKQ MI TT9JNIC DMHEIKQ MN Histamine H3 receptor (H3R) DMHEIKQ MT DTT DMHEIKQ MA Inhibitor DMHEIKQ RN Fluorinated non-imidazole histamine H3 receptor antagonists. Bioorg Med Chem Lett. 2009 Apr 15;19(8):2172-5. DMHEIKQ RU https://pubmed.ncbi.nlm.nih.gov/19286376 DMVXCPE DI DMVXCPE DMVXCPE DN 1-(3-(4-(fluoromethyl)phenoxy)propyl)piperidine DMVXCPE MI TT9JNIC DMVXCPE MN Histamine H3 receptor (H3R) DMVXCPE MT DTT DMVXCPE MA Inhibitor DMVXCPE RN Fluorinated non-imidazole histamine H3 receptor antagonists. Bioorg Med Chem Lett. 2009 Apr 15;19(8):2172-5. DMVXCPE RU https://pubmed.ncbi.nlm.nih.gov/19286376 DMM36DE DI DMM36DE DMM36DE DN 1-(3-(4-chlorobenzyl)quinoxalin-2-yl)hydrazine DMM36DE MI TT3WG5C DMM36DE MN Monoamine oxidase type A (MAO-A) DMM36DE MT DTT DMM36DE MA Inhibitor DMM36DE RN Synthesis of 3-benzyl-2-substituted quinoxalines as novel monoamine oxidase A inhibitors. Bioorg Med Chem Lett. 2006 Mar 15;16(6):1753-6. DMM36DE RU https://pubmed.ncbi.nlm.nih.gov/16356714 DMIFARP DI DMIFARP DMIFARP DN 1-(3-(4-chlorophenyl)propyl)-1H-imidazole DMIFARP MI TTRA5BZ DMIFARP MN Steroid 17-alpha-monooxygenase (S17AH) DMIFARP MT DTT DMIFARP MA Inhibitor DMIFARP RN Synthesis, biochemical evaluation and rationalisation of the inhibitory activity of a range of 4-substituted phenyl alkyl imidazole-based inhibitor... Bioorg Med Chem Lett. 2006 Sep 15;16(18):4752-6. DMIFARP RU https://pubmed.ncbi.nlm.nih.gov/16870430 DMWKXZ2 DI DMWKXZ2 DMWKXZ2 DN 1-(3-(4-fluorophenyl)propyl)-1H-imidazole DMWKXZ2 MI TTSZLWK DMWKXZ2 MN Aromatase (CYP19A1) DMWKXZ2 MT DTT DMWKXZ2 MA Inhibitor DMWKXZ2 RN Pharmacophore modeling strategies for the development of novel nonsteroidal inhibitors of human aromatase (CYP19). Bioorg Med Chem Lett. 2010 May 15;20(10):3050-64. DMWKXZ2 RU https://pubmed.ncbi.nlm.nih.gov/20413308 DMWKXZ2 DI DMWKXZ2 DMWKXZ2 DN 1-(3-(4-fluorophenyl)propyl)-1H-imidazole DMWKXZ2 MI TTRA5BZ DMWKXZ2 MN Steroid 17-alpha-monooxygenase (S17AH) DMWKXZ2 MT DTT DMWKXZ2 MA Inhibitor DMWKXZ2 RN Synthesis, biochemical evaluation and rationalisation of the inhibitory activity of a range of 4-substituted phenyl alkyl imidazole-based inhibitor... Bioorg Med Chem Lett. 2006 Sep 15;16(18):4752-6. DMWKXZ2 RU https://pubmed.ncbi.nlm.nih.gov/16870430 DMQ4MUF DI DMQ4MUF DMQ4MUF DN 1-(3-(benzyloxy)-2-methylphenyl)piperazine DMQ4MUF MI TTJS8PY DMQ4MUF MN 5-HT 6 receptor (HTR6) DMQ4MUF MT DTT DMQ4MUF MA Inhibitor DMQ4MUF RN Synthesis and SAR of tolylamine 5-HT6 antagonists. Bioorg Med Chem Lett. 2009 May 1;19(9):2409-12. DMQ4MUF RU https://pubmed.ncbi.nlm.nih.gov/19346128 DMX5N3V DI DMX5N3V DMX5N3V DN 1-(3-(pentafluorosulfanyl)phenyl)propan-2-amine DMX5N3V MI TTSQIFT DMX5N3V MN 5-HT 1A receptor (HTR1A) DMX5N3V MT DTT DMX5N3V MA Inhibitor DMX5N3V RN The synthesis and biological activity of pentafluorosulfanyl analogs of fluoxetine, fenfluramine, and norfenfluramine. Bioorg Med Chem. 2007 Nov 1;15(21):6659-66. DMX5N3V RU https://pubmed.ncbi.nlm.nih.gov/17765553 DMX5N3V DI DMX5N3V DMX5N3V DN 1-(3-(pentafluorosulfanyl)phenyl)propan-2-amine DMX5N3V MI TTK8CXU DMX5N3V MN 5-HT 1B receptor (HTR1B) DMX5N3V MT DTT DMX5N3V MA Inhibitor DMX5N3V RN The synthesis and biological activity of pentafluorosulfanyl analogs of fluoxetine, fenfluramine, and norfenfluramine. Bioorg Med Chem. 2007 Nov 1;15(21):6659-66. DMX5N3V RU https://pubmed.ncbi.nlm.nih.gov/17765553 DMX5N3V DI DMX5N3V DMX5N3V DN 1-(3-(pentafluorosulfanyl)phenyl)propan-2-amine DMX5N3V MI TT6MSOK DMX5N3V MN 5-HT 1D receptor (HTR1D) DMX5N3V MT DTT DMX5N3V MA Inhibitor DMX5N3V RN The synthesis and biological activity of pentafluorosulfanyl analogs of fluoxetine, fenfluramine, and norfenfluramine. Bioorg Med Chem. 2007 Nov 1;15(21):6659-66. DMX5N3V RU https://pubmed.ncbi.nlm.nih.gov/17765553 DMX5N3V DI DMX5N3V DMX5N3V DN 1-(3-(pentafluorosulfanyl)phenyl)propan-2-amine DMX5N3V MI TTJQOD7 DMX5N3V MN 5-HT 2A receptor (HTR2A) DMX5N3V MT DTT DMX5N3V MA Inhibitor DMX5N3V RN The synthesis and biological activity of pentafluorosulfanyl analogs of fluoxetine, fenfluramine, and norfenfluramine. Bioorg Med Chem. 2007 Nov 1;15(21):6659-66. DMX5N3V RU https://pubmed.ncbi.nlm.nih.gov/17765553 DMX5N3V DI DMX5N3V DMX5N3V DN 1-(3-(pentafluorosulfanyl)phenyl)propan-2-amine DMX5N3V MI TT0K1SC DMX5N3V MN 5-HT 2B receptor (HTR2B) DMX5N3V MT DTT DMX5N3V MA Inhibitor DMX5N3V RN The synthesis and biological activity of pentafluorosulfanyl analogs of fluoxetine, fenfluramine, and norfenfluramine. Bioorg Med Chem. 2007 Nov 1;15(21):6659-66. DMX5N3V RU https://pubmed.ncbi.nlm.nih.gov/17765553 DMX5N3V DI DMX5N3V DMX5N3V DN 1-(3-(pentafluorosulfanyl)phenyl)propan-2-amine DMX5N3V MI TTJS8PY DMX5N3V MN 5-HT 6 receptor (HTR6) DMX5N3V MT DTT DMX5N3V MA Inhibitor DMX5N3V RN The synthesis and biological activity of pentafluorosulfanyl analogs of fluoxetine, fenfluramine, and norfenfluramine. Bioorg Med Chem. 2007 Nov 1;15(21):6659-66. DMX5N3V RU https://pubmed.ncbi.nlm.nih.gov/17765553 DMX5N3V DI DMX5N3V DMX5N3V DN 1-(3-(pentafluorosulfanyl)phenyl)propan-2-amine DMX5N3V MI TTO9X1H DMX5N3V MN 5-HT 7 receptor (HTR7) DMX5N3V MT DTT DMX5N3V MA Inhibitor DMX5N3V RN The synthesis and biological activity of pentafluorosulfanyl analogs of fluoxetine, fenfluramine, and norfenfluramine. Bioorg Med Chem. 2007 Nov 1;15(21):6659-66. DMX5N3V RU https://pubmed.ncbi.nlm.nih.gov/17765553 DMXUNMW DI DMXUNMW DMXUNMW DN 1-(3-(phenylthio)propyl)-4-m-tolylpiperazine DMXUNMW MI TTJQOD7 DMXUNMW MN 5-HT 2A receptor (HTR2A) DMXUNMW MT DTT DMXUNMW MA Inhibitor DMXUNMW RN Synthesis and QSAR studies on hypotensive 1-[3-(4-substituted phenylthio) propyl]-4-(substituted phenyl) piperazines. Bioorg Med Chem Lett. 2007 Mar 15;17(6):1708-12. DMXUNMW RU https://pubmed.ncbi.nlm.nih.gov/17234413 DMNZYWR DI DMNZYWR DMNZYWR DN 1-(3,3-Dimethyl-2-oxo-butyl)-1H-indole-2,3-dione DMNZYWR MI TTPLTSQ DMNZYWR MN Neutrophil elastase (NE) DMNZYWR MT DTT DMNZYWR MA Inhibitor DMNZYWR RN Parallel synthesis of isatin-based serine protease inhibitors. Bioorg Med Chem Lett. 2000 Nov 20;10(22):2501-4. DMNZYWR RU https://pubmed.ncbi.nlm.nih.gov/11086715 DMNZYWR DI DMNZYWR DMNZYWR DN 1-(3,3-Dimethyl-2-oxo-butyl)-1H-indole-2,3-dione DMNZYWR MI TTP86E2 DMNZYWR MN Plasminogen (PLG) DMNZYWR MT DTT DMNZYWR MA Inhibitor DMNZYWR RN Parallel synthesis of isatin-based serine protease inhibitors. Bioorg Med Chem Lett. 2000 Nov 20;10(22):2501-4. DMNZYWR RU https://pubmed.ncbi.nlm.nih.gov/11086715 DM6RO2L DI DM6RO2L DM6RO2L DN 1-(3,3-Diphenyl-allyl)-3-m-tolyl-urea DM6RO2L MI TTCG0AL DM6RO2L MN Cholecystokinin receptor type A (CCKAR) DM6RO2L MT DTT DM6RO2L MA Inhibitor DM6RO2L RN Hybrid cholecystokinin-A antagonists based on molecular modeling of lorglumide and L-364,718. J Med Chem. 1992 Mar 20;35(6):1042-9. DM6RO2L RU https://pubmed.ncbi.nlm.nih.gov/1552499 DMJDK7Z DI DMJDK7Z DMJDK7Z DN 1-(3,3-diphenylpropyl)-4-phenylpiperidin-4-ol DMJDK7Z MI TTNT7K8 DMJDK7Z MN Nociceptin receptor (OPRL1) DMJDK7Z MT DTT DMJDK7Z MA Inhibitor DMJDK7Z RN Bioorg Med Chem Lett. 2007 Jun 1;17(11):3023-7. Epub 2007 Mar 23.Synthesis and structure-activity relationships of 4-hydroxy-4-phenylpiperidines as nociceptin receptor ligands: Part 1. DMJDK7Z RU https://pubmed.ncbi.nlm.nih.gov/17428659 DMX6PKO DI DMX6PKO DMX6PKO DN 1-(3,4-dichlorobenzyl)-1H-imidazole DMX6PKO MI TTRA5BZ DMX6PKO MN Steroid 17-alpha-monooxygenase (S17AH) DMX6PKO MT DTT DMX6PKO MA Inhibitor DMX6PKO RN Synthesis and biochemical evaluation of a range of potent benzyl imidazole-based compounds as potential inhibitors of the enzyme complex 17alpha-hy... Bioorg Med Chem Lett. 2006 Aug 1;16(15):4011-5. DMX6PKO RU https://pubmed.ncbi.nlm.nih.gov/16750362 DMX71K9 DI DMX71K9 DMX71K9 DN 1-(3,4-dichlorobenzyl)-1H-indole-2,3-dione DMX71K9 MI TTEB0GD DMX71K9 MN Cholinesterase (BCHE) DMX71K9 MT DTT DMX71K9 MA Inhibitor DMX71K9 RN Selective inhibition of carboxylesterases by isatins, indole-2,3-diones. J Med Chem. 2007 Apr 19;50(8):1876-85. DMX71K9 RU https://pubmed.ncbi.nlm.nih.gov/17378546 DMX71K9 DI DMX71K9 DMX71K9 DN 1-(3,4-dichlorobenzyl)-1H-indole-2,3-dione DMX71K9 MI TTMF541 DMX71K9 MN Liver carboxylesterase (CES1) DMX71K9 MT DTT DMX71K9 MA Inhibitor DMX71K9 RN Selective inhibition of carboxylesterases by isatins, indole-2,3-diones. J Med Chem. 2007 Apr 19;50(8):1876-85. DMX71K9 RU https://pubmed.ncbi.nlm.nih.gov/17378546 DM4YWEL DI DM4YWEL DM4YWEL DN 1-(3,4-dichlorophenyl)-2-(phenylsulfonyl)ethanone DM4YWEL MI TTN7BL9 DM4YWEL MN Corticosteroid 11-beta-dehydrogenase 1 (HSD11B1) DM4YWEL MT DTT DM4YWEL MA Inhibitor DM4YWEL RN beta-Keto sulfones as inhibitors of 11beta-hydroxysteroid dehydrogenase type I and the mechanism of action. Bioorg Med Chem. 2007 Jul 1;15(13):4396-405. DM4YWEL RU https://pubmed.ncbi.nlm.nih.gov/17490884 DMNOQ49 DI DMNOQ49 DMNOQ49 DN 1-(3,4-dichlorophenyl)-3-(3,5-dichlorophenyl)urea DMNOQ49 MI TTA93TL DMNOQ49 MN P2Y purinoceptor 1 (P2RY1) DMNOQ49 MT DTT DMNOQ49 MA Inhibitor DMNOQ49 RN P2Y1 receptor antagonists as novel antithrombotic agents. Bioorg Med Chem Lett. 2008 Jun 1;18(11):3338-43. DMNOQ49 RU https://pubmed.ncbi.nlm.nih.gov/18445527 DMN4JU0 DI DMN4JU0 DMN4JU0 DN 1-(3,4-Dichloro-phenyl)-3-diethylamino-indan-5-ol DMN4JU0 MI TTVBI8W DMN4JU0 MN Dopamine transporter (DAT) DMN4JU0 MT DTT DMN4JU0 MA Inhibitor DMN4JU0 RN Synthesis and pharmacological evaluation of 3-(3,4-dichlorophenyl)-1-indanamine derivatives as nonselective ligands for biogenic amine transporters. J Med Chem. 2004 May 6;47(10):2624-34. DMN4JU0 RU https://pubmed.ncbi.nlm.nih.gov/15115403 DMN4JU0 DI DMN4JU0 DMN4JU0 DN 1-(3,4-Dichloro-phenyl)-3-diethylamino-indan-5-ol DMN4JU0 MI TTAWNKZ DMN4JU0 MN Norepinephrine transporter (NET) DMN4JU0 MT DTT DMN4JU0 MA Inhibitor DMN4JU0 RN Synthesis and pharmacological evaluation of 3-(3,4-dichlorophenyl)-1-indanamine derivatives as nonselective ligands for biogenic amine transporters. J Med Chem. 2004 May 6;47(10):2624-34. DMN4JU0 RU https://pubmed.ncbi.nlm.nih.gov/15115403 DMN4JU0 DI DMN4JU0 DMN4JU0 DN 1-(3,4-Dichloro-phenyl)-3-diethylamino-indan-5-ol DMN4JU0 MI TT3ROYC DMN4JU0 MN Serotonin transporter (SERT) DMN4JU0 MT DTT DMN4JU0 MA Inhibitor DMN4JU0 RN Synthesis and pharmacological evaluation of 3-(3,4-dichlorophenyl)-1-indanamine derivatives as nonselective ligands for biogenic amine transporters. J Med Chem. 2004 May 6;47(10):2624-34. DMN4JU0 RU https://pubmed.ncbi.nlm.nih.gov/15115403 DMVOJ7K DI DMVOJ7K DMVOJ7K DN 1-(3,4-dichlorophenyl)-3-hydroxyurea DMVOJ7K MI TTUNARX DMVOJ7K MN Carbonic anhydrase (CA) DMVOJ7K MT DTT DMVOJ7K MA Inhibitor DMVOJ7K RN N-hydroxyurea--a versatile zinc binding function in the design of metalloenzyme inhibitors. Bioorg Med Chem Lett. 2006 Aug 15;16(16):4316-20. DMVOJ7K RU https://pubmed.ncbi.nlm.nih.gov/16759856 DMVOJ7K DI DMVOJ7K DMVOJ7K DN 1-(3,4-dichlorophenyl)-3-hydroxyurea DMVOJ7K MI TTANPDJ DMVOJ7K MN Carbonic anhydrase II (CA-II) DMVOJ7K MT DTT DMVOJ7K MA Inhibitor DMVOJ7K RN N-hydroxyurea--a versatile zinc binding function in the design of metalloenzyme inhibitors. Bioorg Med Chem Lett. 2006 Aug 15;16(16):4316-20. DMVOJ7K RU https://pubmed.ncbi.nlm.nih.gov/16759856 DMVOJ7K DI DMVOJ7K DMVOJ7K DN 1-(3,4-dichlorophenyl)-3-hydroxyurea DMVOJ7K MI TTZHA0O DMVOJ7K MN Carbonic anhydrase IV (CA-IV) DMVOJ7K MT DTT DMVOJ7K MA Inhibitor DMVOJ7K RN N-hydroxyurea--a versatile zinc binding function in the design of metalloenzyme inhibitors. Bioorg Med Chem Lett. 2006 Aug 15;16(16):4316-20. DMVOJ7K RU https://pubmed.ncbi.nlm.nih.gov/16759856 DMVOJ7K DI DMVOJ7K DMVOJ7K DN 1-(3,4-dichlorophenyl)-3-hydroxyurea DMVOJ7K MI TT2LVK8 DMVOJ7K MN Carbonic anhydrase IX (CA-IX) DMVOJ7K MT DTT DMVOJ7K MA Inhibitor DMVOJ7K RN N-hydroxyurea--a versatile zinc binding function in the design of metalloenzyme inhibitors. Bioorg Med Chem Lett. 2006 Aug 15;16(16):4316-20. DMVOJ7K RU https://pubmed.ncbi.nlm.nih.gov/16759856 DMWIEDN DI DMWIEDN DMWIEDN DN 1-(3,4-Dichloro-phenyl)-3-methylamino-indan-5-ol DMWIEDN MI TTVBI8W DMWIEDN MN Dopamine transporter (DAT) DMWIEDN MT DTT DMWIEDN MA Inhibitor DMWIEDN RN Synthesis and pharmacological evaluation of 3-(3,4-dichlorophenyl)-1-indanamine derivatives as nonselective ligands for biogenic amine transporters. J Med Chem. 2004 May 6;47(10):2624-34. DMWIEDN RU https://pubmed.ncbi.nlm.nih.gov/15115403 DMWIEDN DI DMWIEDN DMWIEDN DN 1-(3,4-Dichloro-phenyl)-3-methylamino-indan-5-ol DMWIEDN MI TTAWNKZ DMWIEDN MN Norepinephrine transporter (NET) DMWIEDN MT DTT DMWIEDN MA Inhibitor DMWIEDN RN Synthesis and pharmacological evaluation of 3-(3,4-dichlorophenyl)-1-indanamine derivatives as nonselective ligands for biogenic amine transporters. J Med Chem. 2004 May 6;47(10):2624-34. DMWIEDN RU https://pubmed.ncbi.nlm.nih.gov/15115403 DMWIEDN DI DMWIEDN DMWIEDN DN 1-(3,4-Dichloro-phenyl)-3-methylamino-indan-5-ol DMWIEDN MI TT3ROYC DMWIEDN MN Serotonin transporter (SERT) DMWIEDN MT DTT DMWIEDN MA Inhibitor DMWIEDN RN Synthesis and pharmacological evaluation of 3-(3,4-dichlorophenyl)-1-indanamine derivatives as nonselective ligands for biogenic amine transporters. J Med Chem. 2004 May 6;47(10):2624-34. DMWIEDN RU https://pubmed.ncbi.nlm.nih.gov/15115403 DMYZ548 DI DMYZ548 DMYZ548 DN 1-(3,4-DICHLOROPHENYL)-6-(METHOXYMETHYL)-3-AZABICYCLO[4.1.0]HEPTANE (ENANTIOMERIC MIX) DMYZ548 MI TTXV4FI DMYZ548 MN Albendazole monooxygenase (CYP3A4) DMYZ548 MT DTT DMYZ548 MA Inhibitor DMYZ548 RN 6-(3,4-dichlorophenyl)-1-[(methyloxy)methyl]-3-azabicyclo[4.1.0]heptane: a new potent and selective triple reuptake inhibitor. J Med Chem. 2010 Jul 8;53(13):4989-5001. DMYZ548 RU https://pubmed.ncbi.nlm.nih.gov/20527970 DMYZ548 DI DMYZ548 DMYZ548 DN 1-(3,4-DICHLOROPHENYL)-6-(METHOXYMETHYL)-3-AZABICYCLO[4.1.0]HEPTANE (ENANTIOMERIC MIX) DMYZ548 MI TTVG215 DMYZ548 MN Debrisoquine 4-hydroxylase (CYP2D6) DMYZ548 MT DTT DMYZ548 MA Inhibitor DMYZ548 RN 6-(3,4-dichlorophenyl)-1-[(methyloxy)methyl]-3-azabicyclo[4.1.0]heptane: a new potent and selective triple reuptake inhibitor. J Med Chem. 2010 Jul 8;53(13):4989-5001. DMYZ548 RU https://pubmed.ncbi.nlm.nih.gov/20527970 DMRXD2P DI DMRXD2P DMRXD2P DN 1-(3,4-difluorobenzyl)-1H-imidazole DMRXD2P MI TTRA5BZ DMRXD2P MN Steroid 17-alpha-monooxygenase (S17AH) DMRXD2P MT DTT DMRXD2P MA Inhibitor DMRXD2P RN Synthesis and biochemical evaluation of a range of potent benzyl imidazole-based compounds as potential inhibitors of the enzyme complex 17alpha-hy... Bioorg Med Chem Lett. 2006 Aug 1;16(15):4011-5. DMRXD2P RU https://pubmed.ncbi.nlm.nih.gov/16750362 DM5C7I8 DI DM5C7I8 DM5C7I8 DN 1-(3,4-dihydronaphthalen-1-yl)ethanone DM5C7I8 MI TTEAID7 DM5C7I8 MN Trypanosoma Cruzipain (Trypano CYSP) DM5C7I8 MT DTT DM5C7I8 MA Inhibitor DM5C7I8 RN Design, synthesis, and biochemical evaluation of novel cruzain inhibitors with potential application in the treatment of Chagas' disease. Bioorg Med Chem Lett. 2006 Aug 15;16(16):4405-9. DM5C7I8 RU https://pubmed.ncbi.nlm.nih.gov/16781147 DMP93HZ DI DMP93HZ DMP93HZ DN 1-(3,4-dihydronaphthalen-2-yl)-1H-imidazole DMP93HZ MI TTIQUX7 DMP93HZ MN Steroid 11-beta-hydroxylase (CYP11B1) DMP93HZ MT DTT DMP93HZ MA Inhibitor DMP93HZ RN Synthesis and evaluation of heteroaryl-substituted dihydronaphthalenes and indenes: potent and selective inhibitors of aldosterone synthase (CYP11B... J Med Chem. 2006 Apr 6;49(7):2222-31. DMP93HZ RU https://pubmed.ncbi.nlm.nih.gov/16570918 DM9M5D1 DI DM9M5D1 DM9M5D1 DN 1-(3,4-dihydroxy-2-nitrophenyl)-2-phenylethanone DM9M5D1 MI TTKWFB8 DM9M5D1 MN Catechol-O-methyl-transferase (COMT) DM9M5D1 MT DTT DM9M5D1 MA Inhibitor DM9M5D1 RN Synthesis and biological evaluation of a novel series of "ortho-nitrated" inhibitors of catechol-O-methyltransferase. J Med Chem. 2005 Dec 15;48(25):8070-8. DM9M5D1 RU https://pubmed.ncbi.nlm.nih.gov/16335931 DMKI719 DI DMKI719 DMKI719 DN 1-(3,4-dihydroxy-5-nitrophenyl)-2-phenoxyethanone DMKI719 MI TTKWFB8 DMKI719 MN Catechol-O-methyl-transferase (COMT) DMKI719 MT DTT DMKI719 MA Inhibitor DMKI719 RN Synthesis, biological evaluation, and molecular modeling studies of a novel, peripherally selective inhibitor of catechol-O-methyltransferase. J Med Chem. 2004 Dec 2;47(25):6207-17. DMKI719 RU https://pubmed.ncbi.nlm.nih.gov/15566291 DMCHILK DI DMCHILK DMCHILK DN 1-(3,4-Dimethyl-phenyl)-2-phenyl-ethane-1,2-dione DMCHILK MI TTMF541 DMCHILK MN Liver carboxylesterase (CES1) DMCHILK MT DTT DMCHILK MA Inhibitor DMCHILK RN Identification and characterization of novel benzil (diphenylethane-1,2-dione) analogues as inhibitors of mammalian carboxylesterases. J Med Chem. 2005 Apr 21;48(8):2906-15. DMCHILK RU https://pubmed.ncbi.nlm.nih.gov/15828829 DM5WOK8 DI DM5WOK8 DM5WOK8 DN 1-(3,5-bis(trifluoromethyl)benzyl)-1H-imidazole DM5WOK8 MI TTRA5BZ DM5WOK8 MN Steroid 17-alpha-monooxygenase (S17AH) DM5WOK8 MT DTT DM5WOK8 MA Inhibitor DM5WOK8 RN Synthesis and biochemical evaluation of a range of potent benzyl imidazole-based compounds as potential inhibitors of the enzyme complex 17alpha-hy... Bioorg Med Chem Lett. 2006 Aug 1;16(15):4011-5. DM5WOK8 RU https://pubmed.ncbi.nlm.nih.gov/16750362 DMNRCM0 DI DMNRCM0 DMNRCM0 DN 1-(3,5-dibromobenzyl)-1H-imidazole DMNRCM0 MI TTRA5BZ DMNRCM0 MN Steroid 17-alpha-monooxygenase (S17AH) DMNRCM0 MT DTT DMNRCM0 MA Inhibitor DMNRCM0 RN Synthesis and biochemical evaluation of a range of potent benzyl imidazole-based compounds as potential inhibitors of the enzyme complex 17alpha-hy... Bioorg Med Chem Lett. 2006 Aug 1;16(15):4011-5. DMNRCM0 RU https://pubmed.ncbi.nlm.nih.gov/16750362 DMLSWHP DI DMLSWHP DMLSWHP DN 1-(3,5-dichlorobenzyl)-1H-imidazole DMLSWHP MI TTRA5BZ DMLSWHP MN Steroid 17-alpha-monooxygenase (S17AH) DMLSWHP MT DTT DMLSWHP MA Inhibitor DMLSWHP RN Synthesis and biochemical evaluation of a range of potent benzyl imidazole-based compounds as potential inhibitors of the enzyme complex 17alpha-hy... Bioorg Med Chem Lett. 2006 Aug 1;16(15):4011-5. DMLSWHP RU https://pubmed.ncbi.nlm.nih.gov/16750362 DMEAI6V DI DMEAI6V DMEAI6V DN 1-(3,5-difluorobenzyl)-1H-imidazole DMEAI6V MI TTRA5BZ DMEAI6V MN Steroid 17-alpha-monooxygenase (S17AH) DMEAI6V MT DTT DMEAI6V MA Inhibitor DMEAI6V RN Synthesis and biochemical evaluation of a range of potent benzyl imidazole-based compounds as potential inhibitors of the enzyme complex 17alpha-hy... Bioorg Med Chem Lett. 2006 Aug 1;16(15):4011-5. DMEAI6V RU https://pubmed.ncbi.nlm.nih.gov/16750362 DMYJ4EG DI DMYJ4EG DMYJ4EG DN 1-(3,5-dimethylphenyl)-2-(phenylsulfonyl)ethanone DMYJ4EG MI TTN7BL9 DMYJ4EG MN Corticosteroid 11-beta-dehydrogenase 1 (HSD11B1) DMYJ4EG MT DTT DMYJ4EG MA Inhibitor DMYJ4EG RN beta-Keto sulfones as inhibitors of 11beta-hydroxysteroid dehydrogenase type I and the mechanism of action. Bioorg Med Chem. 2007 Jul 1;15(13):4396-405. DMYJ4EG RU https://pubmed.ncbi.nlm.nih.gov/17490884 DMEJZAC DI DMEJZAC DMEJZAC DN 1-(3-Amino-benzyl)-1H-indole-5-carboxamidine DMEJZAC MI TT2WR1T DMEJZAC MN Cationic trypsinogen (PRSS1) DMEJZAC MT DTT DMEJZAC MA Inhibitor DMEJZAC RN Aromatic amidines: comparison of their ability to block respiratory syncytial virus induced cell fusion and to inhibit plasmin, urokinase, thrombin... J Med Chem. 1983 Feb;26(2):294-8. DMEJZAC RU https://pubmed.ncbi.nlm.nih.gov/6219223 DMTY41F DI DMTY41F DMTY41F DN 1-(3-benzyl-6,7-dichloroquinoxalin-2-yl)hydrazine DMTY41F MI TT3WG5C DMTY41F MN Monoamine oxidase type A (MAO-A) DMTY41F MT DTT DMTY41F MA Inhibitor DMTY41F RN Synthesis of 3-benzyl-2-substituted quinoxalines as novel monoamine oxidase A inhibitors. Bioorg Med Chem Lett. 2006 Mar 15;16(6):1753-6. DMTY41F RU https://pubmed.ncbi.nlm.nih.gov/16356714 DMDZAVU DI DMDZAVU DMDZAVU DN 1-(3-benzyloxy-pyridin-2-yl)-3-phenyl-urea DMDZAVU MI TTL2ADK DMDZAVU MN Rotamase A (PPIA) DMDZAVU MT DTT DMDZAVU MA Inhibitor DMDZAVU RN Structure-based design, synthesis, and biological evaluation of novel inhibitors of human cyclophilin A. J Med Chem. 2006 Feb 9;49(3):900-10. DMDZAVU RU https://pubmed.ncbi.nlm.nih.gov/16451056 DMJCVQN DI DMJCVQN DMJCVQN DN 1-(3-benzylquinoxalin-2-yl)hydrazine DMJCVQN MI TT3WG5C DMJCVQN MN Monoamine oxidase type A (MAO-A) DMJCVQN MT DTT DMJCVQN MA Inhibitor DMJCVQN RN Synthesis of 3-benzyl-2-substituted quinoxalines as novel monoamine oxidase A inhibitors. Bioorg Med Chem Lett. 2006 Mar 15;16(6):1753-6. DMJCVQN RU https://pubmed.ncbi.nlm.nih.gov/16356714 DMA59TP DI DMA59TP DMA59TP DN 1-(3-Bromobenzyl)-1H-imidazole DMA59TP MI TTIQUX7 DMA59TP MN Steroid 11-beta-hydroxylase (CYP11B1) DMA59TP MT DTT DMA59TP MA Inhibitor DMA59TP RN Synthesis, biological evaluation, and molecular modeling of 1-benzyl-1H-imidazoles as selective inhibitors of aldosterone synthase (CYP11B2). J Med Chem. 2010 Feb 25;53(4):1712-25. DMA59TP RU https://pubmed.ncbi.nlm.nih.gov/20121113 DM58S47 DI DM58S47 DM58S47 DN 1-(3-Bromomethyl-phenyl)-2,2,2-trifluoro-ethanone DM58S47 MI TT1RS9F DM58S47 MN Acetylcholinesterase (AChE) DM58S47 MT DTT DM58S47 MA Inhibitor DM58S47 RN A structure-based design approach to the development of novel, reversible AChE inhibitors. J Med Chem. 2001 Sep 27;44(20):3203-15. DM58S47 RU https://pubmed.ncbi.nlm.nih.gov/11563919 DM2SEXH DI DM2SEXH DM2SEXH DN 1-(3-bromophenyl)-2-(tert-butylamino)propan-1-one DM2SEXH MI TTVBI8W DM2SEXH MN Dopamine transporter (DAT) DM2SEXH MT DTT DM2SEXH MA Inhibitor DM2SEXH RN Synthesis and biological evaluation of bupropion analogues as potential pharmacotherapies for smoking cessation. J Med Chem. 2010 Mar 11;53(5):2204-14. DM2SEXH RU https://pubmed.ncbi.nlm.nih.gov/20158204 DM2SEXH DI DM2SEXH DM2SEXH DN 1-(3-bromophenyl)-2-(tert-butylamino)propan-1-one DM2SEXH MI TTAWNKZ DM2SEXH MN Norepinephrine transporter (NET) DM2SEXH MT DTT DM2SEXH MA Inhibitor DM2SEXH RN Synthesis and biological evaluation of bupropion analogues as potential pharmacotherapies for smoking cessation. J Med Chem. 2010 Mar 11;53(5):2204-14. DM2SEXH RU https://pubmed.ncbi.nlm.nih.gov/20158204 DMJXOUK DI DMJXOUK DMJXOUK DN 1-(3-CHLORO-4-FLUOROPHENYL)-2,2,2-TRIFLUORO-1-(1-(4-FLUOROPHENYL)-1H-INDAZOL-5-YL)ETHANOL (ENANTIOMERIC MIX) DMJXOUK MI TTOZRK6 DMJXOUK MN Glucocorticoid receptor messenger RNA (GCR mRNA) DMJXOUK MT DTT DMJXOUK MA Inhibitor DMJXOUK RN 5-Functionalized indazoles as glucocorticoid receptor agonists. Bioorg Med Chem Lett. 2010 May 15;20(10):3017-20. DMJXOUK RU https://pubmed.ncbi.nlm.nih.gov/20427184 DM3SQBH DI DM3SQBH DM3SQBH DN 1-(3-Chlorobenzyl)-1H-imidazole DM3SQBH MI TTIQUX7 DM3SQBH MN Steroid 11-beta-hydroxylase (CYP11B1) DM3SQBH MT DTT DM3SQBH MA Inhibitor DM3SQBH RN Synthesis, biological evaluation, and molecular modeling of 1-benzyl-1H-imidazoles as selective inhibitors of aldosterone synthase (CYP11B2). J Med Chem. 2010 Feb 25;53(4):1712-25. DM3SQBH RU https://pubmed.ncbi.nlm.nih.gov/20121113 DMFYJ5V DI DMFYJ5V DMFYJ5V DN 1-(3-chlorophenyl)-2-(dimethylamino)propan-1-one DMFYJ5V MI TTVBI8W DMFYJ5V MN Dopamine transporter (DAT) DMFYJ5V MT DTT DMFYJ5V MA Inhibitor DMFYJ5V RN Synthesis and biological evaluation of bupropion analogues as potential pharmacotherapies for smoking cessation. J Med Chem. 2010 Mar 11;53(5):2204-14. DMFYJ5V RU https://pubmed.ncbi.nlm.nih.gov/20158204 DMFYJ5V DI DMFYJ5V DMFYJ5V DN 1-(3-chlorophenyl)-2-(dimethylamino)propan-1-one DMFYJ5V MI TTAWNKZ DMFYJ5V MN Norepinephrine transporter (NET) DMFYJ5V MT DTT DMFYJ5V MA Inhibitor DMFYJ5V RN Synthesis and biological evaluation of bupropion analogues as potential pharmacotherapies for smoking cessation. J Med Chem. 2010 Mar 11;53(5):2204-14. DMFYJ5V RU https://pubmed.ncbi.nlm.nih.gov/20158204 DMPOVUY DI DMPOVUY DMPOVUY DN 1-(3-chlorophenyl)-2-(piperidin-1-yl)propan-1-one DMPOVUY MI TTVBI8W DMPOVUY MN Dopamine transporter (DAT) DMPOVUY MT DTT DMPOVUY MA Inhibitor DMPOVUY RN Synthesis and biological evaluation of bupropion analogues as potential pharmacotherapies for smoking cessation. J Med Chem. 2010 Mar 11;53(5):2204-14. DMPOVUY RU https://pubmed.ncbi.nlm.nih.gov/20158204 DMPOVUY DI DMPOVUY DMPOVUY DN 1-(3-chlorophenyl)-2-(piperidin-1-yl)propan-1-one DMPOVUY MI TTAWNKZ DMPOVUY MN Norepinephrine transporter (NET) DMPOVUY MT DTT DMPOVUY MA Inhibitor DMPOVUY RN Synthesis and biological evaluation of bupropion analogues as potential pharmacotherapies for smoking cessation. J Med Chem. 2010 Mar 11;53(5):2204-14. DMPOVUY RU https://pubmed.ncbi.nlm.nih.gov/20158204 DMPOVUY DI DMPOVUY DMPOVUY DN 1-(3-chlorophenyl)-2-(piperidin-1-yl)propan-1-one DMPOVUY MI TT3ROYC DMPOVUY MN Serotonin transporter (SERT) DMPOVUY MT DTT DMPOVUY MA Inhibitor DMPOVUY RN Synthesis and biological evaluation of bupropion analogues as potential pharmacotherapies for cocaine addiction. J Med Chem. 2009 Nov 12;52(21):6768-81. DMPOVUY RU https://pubmed.ncbi.nlm.nih.gov/19821577 DMC5PI4 DI DMC5PI4 DMC5PI4 DN 1-(3-Chloro-phenyl)-3-(4-hydroxy-decyl)-urea DMC5PI4 MI TT7WVHI DMC5PI4 MN Soluble epoxide hydrolase (EPHX2) DMC5PI4 MT DTT DMC5PI4 MA Inhibitor DMC5PI4 RN Optimization of amide-based inhibitors of soluble epoxide hydrolase with improved water solubility. J Med Chem. 2005 May 19;48(10):3621-9. DMC5PI4 RU https://pubmed.ncbi.nlm.nih.gov/15887969 DM1VLMC DI DM1VLMC DM1VLMC DN 1-(3-Chloro-phenyl)-3-cyclohexyl-urea DM1VLMC MI TT7WVHI DM1VLMC MN Soluble epoxide hydrolase (EPHX2) DM1VLMC MT DTT DM1VLMC MA Inhibitor DM1VLMC RN Optimization of amide-based inhibitors of soluble epoxide hydrolase with improved water solubility. J Med Chem. 2005 May 19;48(10):3621-9. DM1VLMC RU https://pubmed.ncbi.nlm.nih.gov/15887969 DM6LWR2 DI DM6LWR2 DM6LWR2 DN 1-(3-chloropyridin-2-yl)-4-tosylpiperazine DM6LWR2 MI TTN7BL9 DM6LWR2 MN Corticosteroid 11-beta-dehydrogenase 1 (HSD11B1) DM6LWR2 MT DTT DM6LWR2 MA Inhibitor DM6LWR2 RN Discovery and initial SAR of arylsulfonylpiperazine inhibitors of 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1). Bioorg Med Chem Lett. 2008 Jun 15;18(12):3513-6. DM6LWR2 RU https://pubmed.ncbi.nlm.nih.gov/18511278 DM8DR1B DI DM8DR1B DM8DR1B DN 1-(3-cyano-1-methyl-1H-indol-6-yl)-3-phenylurea DM8DR1B MI TTTB4UP DM8DR1B MN Inosine-5'-monophosphate dehydrogenase 2 (IMPDH2) DM8DR1B MT DTT DM8DR1B MA Inhibitor DM8DR1B RN Novel indole inhibitors of IMPDH from fragments: synthesis and initial structure-activity relationships. Bioorg Med Chem Lett. 2006 May 1;16(9):2539-42. DM8DR1B RU https://pubmed.ncbi.nlm.nih.gov/16483773 DM9KTH6 DI DM9KTH6 DM9KTH6 DN 1-(3-cyano-2-hydroxyphenyl)-3-phenylurea DM9KTH6 MI TT30C9G DM9KTH6 MN C-X-C chemokine receptor type 2 (CXCR2) DM9KTH6 MT DTT DM9KTH6 MA Inhibitor DM9KTH6 RN Comparison of N,N'-diarylsquaramides and N,N'-diarylureas as antagonists of the CXCR2 chemokine receptor. Bioorg Med Chem Lett. 2007 Mar 15;17(6):1713-7. DM9KTH6 RU https://pubmed.ncbi.nlm.nih.gov/17236763 DMVTCGP DI DMVTCGP DMVTCGP DN 1-(3-Cyano-phenyl)-1H-pyrazole-4-carboxylic acid DMVTCGP MI TT7RJY8 DMVTCGP MN Xanthine dehydrogenase/oxidase (XDH) DMVTCGP MT DTT DMVTCGP MA Inhibitor DMVTCGP RN Synthesis and structure-activity relationships of 1-phenylpyrazoles as xanthine oxidase inhibitors. Bioorg Med Chem Lett. 2001 Apr 9;11(7):879-82. DMVTCGP RU https://pubmed.ncbi.nlm.nih.gov/11294382 DM18DB3 DI DM18DB3 DM18DB3 DN 1-(3-Fluorobenzyl)-1H-imidazole DM18DB3 MI TTIQUX7 DM18DB3 MN Steroid 11-beta-hydroxylase (CYP11B1) DM18DB3 MT DTT DM18DB3 MA Inhibitor DM18DB3 RN Synthesis, biological evaluation, and molecular modeling of 1-benzyl-1H-imidazoles as selective inhibitors of aldosterone synthase (CYP11B2). J Med Chem. 2010 Feb 25;53(4):1712-25. DM18DB3 RU https://pubmed.ncbi.nlm.nih.gov/20121113 DM2SNR0 DI DM2SNR0 DM2SNR0 DN 1-(3-Fluoro-phenyl)-piperazine DM2SNR0 MI TTSQIFT DM2SNR0 MN 5-HT 1A receptor (HTR1A) DM2SNR0 MT DTT DM2SNR0 MA Inhibitor DM2SNR0 RN Activity of aromatic substituted phenylpiperazines lacking affinity for dopamine binding sites in a preclinical test of antipsychotic efficacy. J Med Chem. 1989 May;32(5):1052-6. DM2SNR0 RU https://pubmed.ncbi.nlm.nih.gov/2565400 DM2SNR0 DI DM2SNR0 DM2SNR0 DN 1-(3-Fluoro-phenyl)-piperazine DM2SNR0 MI TT6MSOK DM2SNR0 MN 5-HT 1D receptor (HTR1D) DM2SNR0 MT DTT DM2SNR0 MA Inhibitor DM2SNR0 RN Activity of aromatic substituted phenylpiperazines lacking affinity for dopamine binding sites in a preclinical test of antipsychotic efficacy. J Med Chem. 1989 May;32(5):1052-6. DM2SNR0 RU https://pubmed.ncbi.nlm.nih.gov/2565400 DMWFU3T DI DMWFU3T DMWFU3T DN 1-(3-Fluoro-pyridin-2-yl)-4-methyl-piperazine DMWFU3T MI TTNGILX DMWFU3T MN Adrenergic receptor alpha-1A (ADRA1A) DMWFU3T MT DTT DMWFU3T MA Inhibitor DMWFU3T RN Adrenoceptor and tetrabenazine antagonism activities of some pyridinyltetrahydropyridines. J Med Chem. 1984 Sep;27(9):1182-5. DMWFU3T RU https://pubmed.ncbi.nlm.nih.gov/6088770 DMWFU3T DI DMWFU3T DMWFU3T DN 1-(3-Fluoro-pyridin-2-yl)-4-methyl-piperazine DMWFU3T MI TT34BHT DMWFU3T MN Adrenergic receptor alpha-1D (ADRA1D) DMWFU3T MT DTT DMWFU3T MA Inhibitor DMWFU3T RN Adrenoceptor and tetrabenazine antagonism activities of some pyridinyltetrahydropyridines. J Med Chem. 1984 Sep;27(9):1182-5. DMWFU3T RU https://pubmed.ncbi.nlm.nih.gov/6088770 DMWFU3T DI DMWFU3T DMWFU3T DN 1-(3-Fluoro-pyridin-2-yl)-4-methyl-piperazine DMWFU3T MI TTWG9A4 DMWFU3T MN Adrenergic receptor alpha-2A (ADRA2A) DMWFU3T MT DTT DMWFU3T MA Inhibitor DMWFU3T RN Adrenoceptor and tetrabenazine antagonism activities of some pyridinyltetrahydropyridines. J Med Chem. 1984 Sep;27(9):1182-5. DMWFU3T RU https://pubmed.ncbi.nlm.nih.gov/6088770 DMWFU3T DI DMWFU3T DMWFU3T DN 1-(3-Fluoro-pyridin-2-yl)-4-methyl-piperazine DMWFU3T MI TTWM4TY DMWFU3T MN Adrenergic receptor alpha-2B (ADRA2B) DMWFU3T MT DTT DMWFU3T MA Inhibitor DMWFU3T RN Adrenoceptor and tetrabenazine antagonism activities of some pyridinyltetrahydropyridines. J Med Chem. 1984 Sep;27(9):1182-5. DMWFU3T RU https://pubmed.ncbi.nlm.nih.gov/6088770 DMQHFOX DI DMQHFOX DMQHFOX DN 1-(3-Hydroxyphenyl)-4-propylpiperazine DMQHFOX MI TTEX248 DMQHFOX MN Dopamine D2 receptor (D2R) DMQHFOX MT DTT DMQHFOX MA Inhibitor DMQHFOX RN Synthesis and evaluation of a set of 4-phenylpiperidines and 4-phenylpiperazines as D2 receptor ligands and the discovery of the dopaminergic stabi... J Med Chem. 2010 Mar 25;53(6):2510-20. DMQHFOX RU https://pubmed.ncbi.nlm.nih.gov/20155917 DMPEZ1V DI DMPEZ1V DMPEZ1V DN 1-(3-iodophenyl)-2-pyrrolidin-1-yl-pentan-1-one DMPEZ1V MI TTVBI8W DMPEZ1V MN Dopamine transporter (DAT) DMPEZ1V MT DTT DMPEZ1V MA Inhibitor DMPEZ1V RN 1-(4-Methylphenyl)-2-pyrrolidin-1-yl-pentan-1-one (Pyrovalerone) analogues: a promising class of monoamine uptake inhibitors. J Med Chem. 2006 Feb 23;49(4):1420-32. DMPEZ1V RU https://pubmed.ncbi.nlm.nih.gov/16480278 DMPEZ1V DI DMPEZ1V DMPEZ1V DN 1-(3-iodophenyl)-2-pyrrolidin-1-yl-pentan-1-one DMPEZ1V MI TTAWNKZ DMPEZ1V MN Norepinephrine transporter (NET) DMPEZ1V MT DTT DMPEZ1V MA Inhibitor DMPEZ1V RN 1-(4-Methylphenyl)-2-pyrrolidin-1-yl-pentan-1-one (Pyrovalerone) analogues: a promising class of monoamine uptake inhibitors. J Med Chem. 2006 Feb 23;49(4):1420-32. DMPEZ1V RU https://pubmed.ncbi.nlm.nih.gov/16480278 DMPEZ1V DI DMPEZ1V DMPEZ1V DN 1-(3-iodophenyl)-2-pyrrolidin-1-yl-pentan-1-one DMPEZ1V MI TT3ROYC DMPEZ1V MN Serotonin transporter (SERT) DMPEZ1V MT DTT DMPEZ1V MA Inhibitor DMPEZ1V RN 1-(4-Methylphenyl)-2-pyrrolidin-1-yl-pentan-1-one (Pyrovalerone) analogues: a promising class of monoamine uptake inhibitors. J Med Chem. 2006 Feb 23;49(4):1420-32. DMPEZ1V RU https://pubmed.ncbi.nlm.nih.gov/16480278 DM30M9H DI DM30M9H DM30M9H DN 1-(3-Methoxy-benzyl)-5-methyl-1H-indole-2,3-dione DM30M9H MI TTEAID7 DM30M9H MN Trypanosoma Cruzipain (Trypano CYSP) DM30M9H MT DTT DM30M9H MA Inhibitor DM30M9H RN Synthesis and evaluation of isatins and thiosemicarbazone derivatives against cruzain, falcipain-2 and rhodesain. Bioorg Med Chem Lett. 2003 Oct 20;13(20):3527-30. DM30M9H RU https://pubmed.ncbi.nlm.nih.gov/14505663 DM16U5F DI DM16U5F DM16U5F DN 1-(3-Methoxy-naphthalen-2-yl)-1H-imidazole DM16U5F MI TTSZLWK DM16U5F MN Aromatase (CYP19A1) DM16U5F MT DTT DM16U5F MA Inhibitor DM16U5F RN Heteroaryl-substituted naphthalenes and structurally modified derivatives: selective inhibitors of CYP11B2 for the treatment of congestive heart fa... J Med Chem. 2005 Oct 20;48(21):6632-42. DM16U5F RU https://pubmed.ncbi.nlm.nih.gov/16220979 DM16U5F DI DM16U5F DM16U5F DN 1-(3-Methoxy-naphthalen-2-yl)-1H-imidazole DM16U5F MI TTIQUX7 DM16U5F MN Steroid 11-beta-hydroxylase (CYP11B1) DM16U5F MT DTT DM16U5F MA Inhibitor DM16U5F RN Heteroaryl-substituted naphthalenes and structurally modified derivatives: selective inhibitors of CYP11B2 for the treatment of congestive heart fa... J Med Chem. 2005 Oct 20;48(21):6632-42. DM16U5F RU https://pubmed.ncbi.nlm.nih.gov/16220979 DMGU7MO DI DMGU7MO DMGU7MO DN 1-(3-methoxyphenethyl)pyrrolidine DMGU7MO MI TT9JNIC DMGU7MO MN Histamine H3 receptor (H3R) DMGU7MO MT DTT DMGU7MO MA Inhibitor DMGU7MO RN In vitro SAR of pyrrolidine-containing histamine H3 receptor antagonists: trends across multiple chemical series. Bioorg Med Chem Lett. 2008 Jan 1;18(1):355-9. DMGU7MO RU https://pubmed.ncbi.nlm.nih.gov/18077160 DMR0ICB DI DMR0ICB DMR0ICB DN 1-(3-methoxyphenyl)-2-(phenylsulfonyl)ethanone DMR0ICB MI TTN7BL9 DMR0ICB MN Corticosteroid 11-beta-dehydrogenase 1 (HSD11B1) DMR0ICB MT DTT DMR0ICB MA Inhibitor DMR0ICB RN beta-Keto sulfones as inhibitors of 11beta-hydroxysteroid dehydrogenase type I and the mechanism of action. Bioorg Med Chem. 2007 Jul 1;15(13):4396-405. DMR0ICB RU https://pubmed.ncbi.nlm.nih.gov/17490884 DMI15LJ DI DMI15LJ DMI15LJ DN 1-(3-Methylbutylidene)thiosemicarbazide DMI15LJ MI TTULVH8 DMI15LJ MN Tyrosinase (TYR) DMI15LJ MT DTT DMI15LJ MA Inhibitor DMI15LJ RN A class of potent tyrosinase inhibitors: alkylidenethiosemicarbazide compounds. Eur J Med Chem. 2009 Apr;44(4):1773-8. DMI15LJ RU https://pubmed.ncbi.nlm.nih.gov/18524420 DMB9T6F DI DMB9T6F DMB9T6F DN 1-(3-methylphenyl)-2-pyrrolidin-1-yl-pentan-1-one DMB9T6F MI TTVBI8W DMB9T6F MN Dopamine transporter (DAT) DMB9T6F MT DTT DMB9T6F MA Inhibitor DMB9T6F RN 1-(4-Methylphenyl)-2-pyrrolidin-1-yl-pentan-1-one (Pyrovalerone) analogues: a promising class of monoamine uptake inhibitors. J Med Chem. 2006 Feb 23;49(4):1420-32. DMB9T6F RU https://pubmed.ncbi.nlm.nih.gov/16480278 DMB9T6F DI DMB9T6F DMB9T6F DN 1-(3-methylphenyl)-2-pyrrolidin-1-yl-pentan-1-one DMB9T6F MI TTAWNKZ DMB9T6F MN Norepinephrine transporter (NET) DMB9T6F MT DTT DMB9T6F MA Inhibitor DMB9T6F RN 1-(4-Methylphenyl)-2-pyrrolidin-1-yl-pentan-1-one (Pyrovalerone) analogues: a promising class of monoamine uptake inhibitors. J Med Chem. 2006 Feb 23;49(4):1420-32. DMB9T6F RU https://pubmed.ncbi.nlm.nih.gov/16480278 DMB9T6F DI DMB9T6F DMB9T6F DN 1-(3-methylphenyl)-2-pyrrolidin-1-yl-pentan-1-one DMB9T6F MI TT3ROYC DMB9T6F MN Serotonin transporter (SERT) DMB9T6F MT DTT DMB9T6F MA Inhibitor DMB9T6F RN 1-(4-Methylphenyl)-2-pyrrolidin-1-yl-pentan-1-one (Pyrovalerone) analogues: a promising class of monoamine uptake inhibitors. J Med Chem. 2006 Feb 23;49(4):1420-32. DMB9T6F RU https://pubmed.ncbi.nlm.nih.gov/16480278 DMYH9M0 DI DMYH9M0 DMYH9M0 DN 1-(3-methylpyridin-2-yl)-4-tosylpiperazine DMYH9M0 MI TTN7BL9 DMYH9M0 MN Corticosteroid 11-beta-dehydrogenase 1 (HSD11B1) DMYH9M0 MT DTT DMYH9M0 MA Inhibitor DMYH9M0 RN Discovery and initial SAR of arylsulfonylpiperazine inhibitors of 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1). Bioorg Med Chem Lett. 2008 Jun 15;18(12):3513-6. DMYH9M0 RU https://pubmed.ncbi.nlm.nih.gov/18511278 DM3RGLE DI DM3RGLE DM3RGLE DN 1-(3-Nitro-benzyl)-1H-indole-5-carboxamidine DM3RGLE MI TT2WR1T DM3RGLE MN Cationic trypsinogen (PRSS1) DM3RGLE MT DTT DM3RGLE MA Inhibitor DM3RGLE RN Aromatic amidines: comparison of their ability to block respiratory syncytial virus induced cell fusion and to inhibit plasmin, urokinase, thrombin... J Med Chem. 1983 Feb;26(2):294-8. DM3RGLE RU https://pubmed.ncbi.nlm.nih.gov/6219223 DMMJC5E DI DMMJC5E DMMJC5E DN 1-(3-Nitro-phenyl)-piperazine DMMJC5E MI TTSQIFT DMMJC5E MN 5-HT 1A receptor (HTR1A) DMMJC5E MT DTT DMMJC5E MA Inhibitor DMMJC5E RN Activity of aromatic substituted phenylpiperazines lacking affinity for dopamine binding sites in a preclinical test of antipsychotic efficacy. J Med Chem. 1989 May;32(5):1052-6. DMMJC5E RU https://pubmed.ncbi.nlm.nih.gov/2565400 DMMJC5E DI DMMJC5E DMMJC5E DN 1-(3-Nitro-phenyl)-piperazine DMMJC5E MI TT6MSOK DMMJC5E MN 5-HT 1D receptor (HTR1D) DMMJC5E MT DTT DMMJC5E MA Inhibitor DMMJC5E RN Activity of aromatic substituted phenylpiperazines lacking affinity for dopamine binding sites in a preclinical test of antipsychotic efficacy. J Med Chem. 1989 May;32(5):1052-6. DMMJC5E RU https://pubmed.ncbi.nlm.nih.gov/2565400 DM3FP6J DI DM3FP6J DM3FP6J DN 1-(3-nitropyridin-2-yl)-4-tosylpiperazine DM3FP6J MI TTN7BL9 DM3FP6J MN Corticosteroid 11-beta-dehydrogenase 1 (HSD11B1) DM3FP6J MT DTT DM3FP6J MA Inhibitor DM3FP6J RN Discovery and initial SAR of arylsulfonylpiperazine inhibitors of 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1). Bioorg Med Chem Lett. 2008 Jun 15;18(12):3513-6. DM3FP6J RU https://pubmed.ncbi.nlm.nih.gov/18511278 DMEMHIF DI DMEMHIF DMEMHIF DN 1-(3-Oxocyclohexylidene)thiosemicarbazide DMEMHIF MI TTULVH8 DMEMHIF MN Tyrosinase (TYR) DMEMHIF MT DTT DMEMHIF MA Inhibitor DMEMHIF RN A class of potent tyrosinase inhibitors: alkylidenethiosemicarbazide compounds. Eur J Med Chem. 2009 Apr;44(4):1773-8. DMEMHIF RU https://pubmed.ncbi.nlm.nih.gov/18524420 DMG8DLM DI DMG8DLM DMG8DLM DN 1-(3-phenoxypropyl)-4-(piperidin-1-yl)piperidine DMG8DLM MI TTULVH8 DMG8DLM MN Tyrosinase (TYR) DMG8DLM MT DTT DMG8DLM MA Inhibitor DMG8DLM RN Dragon method for finding novel tyrosinase inhibitors: Biosilico identification and experimental in vitro assays. Eur J Med Chem. 2007 Nov-Dec;42(11-12):1370-81. DMG8DLM RU https://pubmed.ncbi.nlm.nih.gov/17637486 DMFPUGV DI DMFPUGV DMFPUGV DN 1-(3-Phenylallylidene)thiosemicarbazide DMFPUGV MI TTULVH8 DMFPUGV MN Tyrosinase (TYR) DMFPUGV MT DTT DMFPUGV MA Inhibitor DMFPUGV RN A class of potent tyrosinase inhibitors: alkylidenethiosemicarbazide compounds. Eur J Med Chem. 2009 Apr;44(4):1773-8. DMFPUGV RU https://pubmed.ncbi.nlm.nih.gov/18524420 DMPAWFJ DI DMPAWFJ DMPAWFJ DN 1-(3-phenylpropyl)-1H-imidazole DMPAWFJ MI TTRA5BZ DMPAWFJ MN Steroid 17-alpha-monooxygenase (S17AH) DMPAWFJ MT DTT DMPAWFJ MA Inhibitor DMPAWFJ RN Synthesis, biochemical evaluation and rationalisation of the inhibitory activity of a range of 4-substituted phenyl alkyl imidazole-based inhibitor... Bioorg Med Chem Lett. 2006 Sep 15;16(18):4752-6. DMPAWFJ RU https://pubmed.ncbi.nlm.nih.gov/16870430 DM37RI9 DI DM37RI9 DM37RI9 DN 1-(3-Phenyl-propyl)-3-thiazol-2-yl-thiourea DM37RI9 MI TT84ETX DM37RI9 MN Human immunodeficiency virus Reverse transcriptase (HIV RT) DM37RI9 MT DTT DM37RI9 MA Inhibitor DM37RI9 RN Phenethylthiazolethiourea (PETT) compounds, a new class of HIV-1 reverse transcriptase inhibitors. 1. Synthesis and basic structure-activity relati... J Med Chem. 1995 Dec 8;38(25):4929-36. DM37RI9 RU https://pubmed.ncbi.nlm.nih.gov/8523406 DMZPJM4 DI DMZPJM4 DMZPJM4 DN 1-(3-tritylaminopropyl)uracil DMZPJM4 MI TTY8KJS DMZPJM4 MN Bacterial Deoxyuridine triphosphate nucleotidohydrolase (Bact dut) DMZPJM4 MT DTT DMZPJM4 MA Inhibitor DMZPJM4 RN Acyclic nucleoside analogues as inhibitors of Plasmodium falciparum dUTPase. J Med Chem. 2006 Jul 13;49(14):4183-95. DMZPJM4 RU https://pubmed.ncbi.nlm.nih.gov/16821778 DMUDVRM DI DMUDVRM DMUDVRM DN 1-(4-(1H-pyrazol-1-yl)benzyl)-4-phenylpiperazine DMUDVRM MI TTZFYLI DMUDVRM MN Dopamine D1 receptor (D1R) DMUDVRM MT DTT DMUDVRM MA Inhibitor DMUDVRM RN Synthesis and biological investigations of dopaminergic partial agonists preferentially recognizing the D4 receptor subtype. Bioorg Med Chem Lett. 2006 Jun 1;16(11):2955-9. DMUDVRM RU https://pubmed.ncbi.nlm.nih.gov/16563764 DMUDVRM DI DMUDVRM DMUDVRM DN 1-(4-(1H-pyrazol-1-yl)benzyl)-4-phenylpiperazine DMUDVRM MI TTEX248 DMUDVRM MN Dopamine D2 receptor (D2R) DMUDVRM MT DTT DMUDVRM MA Inhibitor DMUDVRM RN Synthesis and biological investigations of dopaminergic partial agonists preferentially recognizing the D4 receptor subtype. Bioorg Med Chem Lett. 2006 Jun 1;16(11):2955-9. DMUDVRM RU https://pubmed.ncbi.nlm.nih.gov/16563764 DMUDVRM DI DMUDVRM DMUDVRM DN 1-(4-(1H-pyrazol-1-yl)benzyl)-4-phenylpiperazine DMUDVRM MI TT4C8EA DMUDVRM MN Dopamine D3 receptor (D3R) DMUDVRM MT DTT DMUDVRM MA Inhibitor DMUDVRM RN Synthesis and biological investigations of dopaminergic partial agonists preferentially recognizing the D4 receptor subtype. Bioorg Med Chem Lett. 2006 Jun 1;16(11):2955-9. DMUDVRM RU https://pubmed.ncbi.nlm.nih.gov/16563764 DMUDVRM DI DMUDVRM DMUDVRM DN 1-(4-(1H-pyrazol-1-yl)benzyl)-4-phenylpiperazine DMUDVRM MI TTE0A2F DMUDVRM MN Dopamine D4 receptor (D4R) DMUDVRM MT DTT DMUDVRM MA Inhibitor DMUDVRM RN Synthesis and biological investigations of dopaminergic partial agonists preferentially recognizing the D4 receptor subtype. Bioorg Med Chem Lett. 2006 Jun 1;16(11):2955-9. DMUDVRM RU https://pubmed.ncbi.nlm.nih.gov/16563764 DMYIK9W DI DMYIK9W DMYIK9W DN 1-(4-(3-morpholinopropoxy)phenyl)-3-phenylurea DMYIK9W MI TT7WVHI DMYIK9W MN Soluble epoxide hydrolase (EPHX2) DMYIK9W MT DTT DMYIK9W MA Inhibitor DMYIK9W RN Unsymmetrical non-adamantyl N,N'-diaryl urea and amide inhibitors of soluble expoxide hydrolase. Bioorg Med Chem Lett. 2009 Aug 1;19(15):4259-63. DMYIK9W RU https://pubmed.ncbi.nlm.nih.gov/19520575 DMM18AQ DI DMM18AQ DMM18AQ DN 1-(4-(4-phenyl-1-piperazinyl)butyl)indolin-2-one DMM18AQ MI TTEX248 DMM18AQ MN Dopamine D2 receptor (D2R) DMM18AQ MT DTT DMM18AQ MA Inhibitor DMM18AQ RN Synthesis of novel lactam derivatives and their evaluation as ligands for the dopamine receptors, leading to a D(4)-selective ligand. Bioorg Med Chem. 2007 Sep 1;15(17):5811-8. DMM18AQ RU https://pubmed.ncbi.nlm.nih.gov/17576067 DMM18AQ DI DMM18AQ DMM18AQ DN 1-(4-(4-phenyl-1-piperazinyl)butyl)indolin-2-one DMM18AQ MI TT4C8EA DMM18AQ MN Dopamine D3 receptor (D3R) DMM18AQ MT DTT DMM18AQ MA Inhibitor DMM18AQ RN Synthesis of novel lactam derivatives and their evaluation as ligands for the dopamine receptors, leading to a D(4)-selective ligand. Bioorg Med Chem. 2007 Sep 1;15(17):5811-8. DMM18AQ RU https://pubmed.ncbi.nlm.nih.gov/17576067 DMM18AQ DI DMM18AQ DMM18AQ DN 1-(4-(4-phenyl-1-piperazinyl)butyl)indolin-2-one DMM18AQ MI TTS2PH3 DMM18AQ MN Dopamine D5 receptor (D5R) DMM18AQ MT DTT DMM18AQ MA Inhibitor DMM18AQ RN Synthesis of novel lactam derivatives and their evaluation as ligands for the dopamine receptors, leading to a D(4)-selective ligand. Bioorg Med Chem. 2007 Sep 1;15(17):5811-8. DMM18AQ RU https://pubmed.ncbi.nlm.nih.gov/17576067 DMT3H0K DI DMT3H0K DMT3H0K DN 1-(4-(benzyloxy)phenethyl)pyrrolidine DMT3H0K MI TT9JNIC DMT3H0K MN Histamine H3 receptor (H3R) DMT3H0K MT DTT DMT3H0K MA Inhibitor DMT3H0K RN In vitro SAR of pyrrolidine-containing histamine H3 receptor antagonists: trends across multiple chemical series. Bioorg Med Chem Lett. 2008 Jan 1;18(1):355-9. DMT3H0K RU https://pubmed.ncbi.nlm.nih.gov/18077160 DM7FWK8 DI DM7FWK8 DM7FWK8 DN 1-(4-(benzyloxy)phenyl)-3-hydroxyurea DM7FWK8 MI TTULVH8 DM7FWK8 MN Tyrosinase (TYR) DM7FWK8 MT DTT DM7FWK8 MA Inhibitor DM7FWK8 RN Analogues of N-hydroxy-N'-phenylthiourea and N-hydroxy-N'-phenylurea as inhibitors of tyrosinase and melanin formation. Bioorg Med Chem Lett. 2008 Jun 15;18(12):3607-10. DM7FWK8 RU https://pubmed.ncbi.nlm.nih.gov/18501598 DMT81N3 DI DMT81N3 DMT81N3 DN 1-(4-(benzyloxy)phenyl)propan-2-amine DMT81N3 MI TT3WG5C DMT81N3 MN Monoamine oxidase type A (MAO-A) DMT81N3 MT DTT DMT81N3 MA Inhibitor DMT81N3 RN Naphthylisopropylamine and N-benzylamphetamine derivatives as monoamine oxidase inhibitors. Bioorg Med Chem. 2009 Mar 15;17(6):2452-60. DMT81N3 RU https://pubmed.ncbi.nlm.nih.gov/19243954 DMT81N3 DI DMT81N3 DMT81N3 DN 1-(4-(benzyloxy)phenyl)propan-2-amine DMT81N3 MI TTGP7BY DMT81N3 MN Monoamine oxidase type B (MAO-B) DMT81N3 MT DTT DMT81N3 MA Inhibitor DMT81N3 RN Naphthylisopropylamine and N-benzylamphetamine derivatives as monoamine oxidase inhibitors. Bioorg Med Chem. 2009 Mar 15;17(6):2452-60. DMT81N3 RU https://pubmed.ncbi.nlm.nih.gov/19243954 DMLODAM DI DMLODAM DMLODAM DN 1-(4-(Hexyloxy)phenyl)-3-morpholinopropan-1-one DMLODAM MI TTGER3L DMLODAM MN Thyroid hormone receptor beta (THRB) DMLODAM MT DTT DMLODAM MA Inhibitor DMLODAM RN Improvement of pharmacological properties of irreversible thyroid receptor coactivator binding inhibitors. J Med Chem. 2009 Jul 9;52(13):3892-901. DMLODAM RU https://pubmed.ncbi.nlm.nih.gov/19469546 DMCE7G0 DI DMCE7G0 DMCE7G0 DN 1-(4-(methylsulfonyl)phenyl)-1H-indole DMCE7G0 MI TTVKILB DMCE7G0 MN Prostaglandin G/H synthase 2 (COX-2) DMCE7G0 MT DTT DMCE7G0 MA Inhibitor DMCE7G0 RN Synthesis, anti-inflammatory activity, and in vitro antitumor effect of a novel class of cyclooxygenase inhibitors: 4-(aryloyl)phenyl methyl sulfones. J Med Chem. 2010 Sep 23;53(18):6560-71. DMCE7G0 RU https://pubmed.ncbi.nlm.nih.gov/20804197 DMYFBRQ DI DMYFBRQ DMYFBRQ DN 1-(4-(methylsulfonyl)phenyl)-1H-pyrrole DMYFBRQ MI TTVKILB DMYFBRQ MN Prostaglandin G/H synthase 2 (COX-2) DMYFBRQ MT DTT DMYFBRQ MA Inhibitor DMYFBRQ RN Synthesis, anti-inflammatory activity, and in vitro antitumor effect of a novel class of cyclooxygenase inhibitors: 4-(aryloyl)phenyl methyl sulfones. J Med Chem. 2010 Sep 23;53(18):6560-71. DMYFBRQ RU https://pubmed.ncbi.nlm.nih.gov/20804197 DMH7RY0 DI DMH7RY0 DMH7RY0 DN 1-(4-(methylsulfonyl)phenyl)-3-phenylurea DMH7RY0 MI TT8NGED DMH7RY0 MN Prostaglandin G/H synthase 1 (COX-1) DMH7RY0 MT DTT DMH7RY0 MA Inhibitor DMH7RY0 RN Design and synthesis of 1,3-diarylurea derivatives as selective cyclooxygenase (COX-2) inhibitors. Bioorg Med Chem Lett. 2008 Feb 15;18(4):1336-9. DMH7RY0 RU https://pubmed.ncbi.nlm.nih.gov/18226898 DMH7RY0 DI DMH7RY0 DMH7RY0 DN 1-(4-(methylsulfonyl)phenyl)-3-phenylurea DMH7RY0 MI TTVKILB DMH7RY0 MN Prostaglandin G/H synthase 2 (COX-2) DMH7RY0 MT DTT DMH7RY0 MA Inhibitor DMH7RY0 RN Design and synthesis of 1,3-diarylurea derivatives as selective cyclooxygenase (COX-2) inhibitors. Bioorg Med Chem Lett. 2008 Feb 15;18(4):1336-9. DMH7RY0 RU https://pubmed.ncbi.nlm.nih.gov/18226898 DMMSQLC DI DMMSQLC DMMSQLC DN 1-(4-(methylsulfonyl)phenyl)-3-p-tolylurea DMMSQLC MI TT8NGED DMMSQLC MN Prostaglandin G/H synthase 1 (COX-1) DMMSQLC MT DTT DMMSQLC MA Inhibitor DMMSQLC RN Design and synthesis of 1,3-diarylurea derivatives as selective cyclooxygenase (COX-2) inhibitors. Bioorg Med Chem Lett. 2008 Feb 15;18(4):1336-9. DMMSQLC RU https://pubmed.ncbi.nlm.nih.gov/18226898 DMMSQLC DI DMMSQLC DMMSQLC DN 1-(4-(methylsulfonyl)phenyl)-3-p-tolylurea DMMSQLC MI TTVKILB DMMSQLC MN Prostaglandin G/H synthase 2 (COX-2) DMMSQLC MT DTT DMMSQLC MA Inhibitor DMMSQLC RN Design and synthesis of 1,3-diarylurea derivatives as selective cyclooxygenase (COX-2) inhibitors. Bioorg Med Chem Lett. 2008 Feb 15;18(4):1336-9. DMMSQLC RU https://pubmed.ncbi.nlm.nih.gov/18226898 DM170BV DI DM170BV DM170BV DN 1-(4-acetyloxazol-2-yl)-7-phenylheptan-1-one DM170BV MI TTDP1UC DM170BV MN Fatty acid amide hydrolase (FAAH) DM170BV MT DTT DM170BV MA Inhibitor DM170BV RN Exploration of a fundamental substituent effect of alpha-ketoheterocycle enzyme inhibitors: Potent and selective inhibitors of fatty acid amide hyd... Bioorg Med Chem Lett. 2008 Nov 15;18(22):5842-6. DM170BV RU https://pubmed.ncbi.nlm.nih.gov/18639454 DMOZAM6 DI DMOZAM6 DMOZAM6 DN 1-(4-Aminobenzyl)-1H-imidazole DMOZAM6 MI TTIQUX7 DMOZAM6 MN Steroid 11-beta-hydroxylase (CYP11B1) DMOZAM6 MT DTT DMOZAM6 MA Inhibitor DMOZAM6 RN Synthesis, biological evaluation, and molecular modeling of 1-benzyl-1H-imidazoles as selective inhibitors of aldosterone synthase (CYP11B2). J Med Chem. 2010 Feb 25;53(4):1712-25. DMOZAM6 RU https://pubmed.ncbi.nlm.nih.gov/20121113 DMMYT4W DI DMMYT4W DMMYT4W DN 1-(4-Aminophenyl)-2-(1H-imidazol-1-yl)ethanone DMMYT4W MI TTSZLWK DMMYT4W MN Aromatase (CYP19A1) DMMYT4W MT DTT DMMYT4W MA Inhibitor DMMYT4W RN Design, synthesis, and biological evaluation of resveratrol analogues as aromatase and quinone reductase 2 inhibitors for chemoprevention of cancer. Bioorg Med Chem. 2010 Jul 15;18(14):5352-66. DMMYT4W RU https://pubmed.ncbi.nlm.nih.gov/20558073 DMY7TDZ DI DMY7TDZ DMY7TDZ DN 1-(4-aminophenyl)-2-pyrrolidin-1-yl-pentan-1-one DMY7TDZ MI TTVBI8W DMY7TDZ MN Dopamine transporter (DAT) DMY7TDZ MT DTT DMY7TDZ MA Inhibitor DMY7TDZ RN A novel photoaffinity ligand for the dopamine transporter based on pyrovalerone. Bioorg Med Chem. 2009 Jun 1;17(11):3770-4. DMY7TDZ RU https://pubmed.ncbi.nlm.nih.gov/19442525 DM4G0NH DI DM4G0NH DM4G0NH DN 1-(4-aminophenylsulfonyl)-3-(2-mercaptoethyl)urea DM4G0NH MI TTWHDVK DM4G0NH MN Fructose-1,6-bisphosphatase (FBP) DM4G0NH MT DTT DM4G0NH MA Inhibitor DM4G0NH RN Allosteric FBPase inhibitors gain 10(5) times in potency when simultaneously binding two neighboring AMP sites. Bioorg Med Chem Lett. 2008 Aug 15;18(16):4708-12. DM4G0NH RU https://pubmed.ncbi.nlm.nih.gov/18650089 DMWA6G1 DI DMWA6G1 DMWA6G1 DN 1-(4-aminosulfonylphenyl)-2-(2-pyridyl)acetylene DMWA6G1 MI TT8NGED DMWA6G1 MN Prostaglandin G/H synthase 1 (COX-1) DMWA6G1 MT DTT DMWA6G1 MA Inhibitor DMWA6G1 RN Synthesis and cyclooxygenase inhibitory activities of linear 1-(methanesulfonylphenyl or benzenesulfonamido)-2-(pyridyl)acetylene regioisomers. Bioorg Med Chem. 2008 Feb 15;16(4):1948-56. DMWA6G1 RU https://pubmed.ncbi.nlm.nih.gov/18023187 DMWA6G1 DI DMWA6G1 DMWA6G1 DN 1-(4-aminosulfonylphenyl)-2-(2-pyridyl)acetylene DMWA6G1 MI TTVKILB DMWA6G1 MN Prostaglandin G/H synthase 2 (COX-2) DMWA6G1 MT DTT DMWA6G1 MA Inhibitor DMWA6G1 RN Synthesis and cyclooxygenase inhibitory activities of linear 1-(methanesulfonylphenyl or benzenesulfonamido)-2-(pyridyl)acetylene regioisomers. Bioorg Med Chem. 2008 Feb 15;16(4):1948-56. DMWA6G1 RU https://pubmed.ncbi.nlm.nih.gov/18023187 DMP93E2 DI DMP93E2 DMP93E2 DN 1-(4-aminosulfonylphenyl)-2-(4-pyridyl)acetylene DMP93E2 MI TT8NGED DMP93E2 MN Prostaglandin G/H synthase 1 (COX-1) DMP93E2 MT DTT DMP93E2 MA Inhibitor DMP93E2 RN Synthesis and cyclooxygenase inhibitory activities of linear 1-(methanesulfonylphenyl or benzenesulfonamido)-2-(pyridyl)acetylene regioisomers. Bioorg Med Chem. 2008 Feb 15;16(4):1948-56. DMP93E2 RU https://pubmed.ncbi.nlm.nih.gov/18023187 DMXV9S7 DI DMXV9S7 DMXV9S7 DN 1-(4-Benzylsulfanyl-phenyl)-propylamine DMXV9S7 MI TT3ROYC DMXV9S7 MN Serotonin transporter (SERT) DMXV9S7 MT DTT DMXV9S7 MA Inhibitor DMXV9S7 RN Synthesis and serotonin transporter activity of sulphur-substituted alpha-alkyl phenethylamines as a new class of anticancer agents. Eur J Med Chem. 2009 Dec;44(12):4862-88. DMXV9S7 RU https://pubmed.ncbi.nlm.nih.gov/19717215 DMMLCSG DI DMMLCSG DMMLCSG DN 1-(4-Bromo-2,5-difluorophenyl)-2-aminopropane DMMLCSG MI TTJQOD7 DMMLCSG MN 5-HT 2A receptor (HTR2A) DMMLCSG MT DTT DMMLCSG MA Inhibitor DMMLCSG RN The role of lipophilicity in determining binding affinity and functional activity for 5-HT2A receptor ligands. Bioorg Med Chem. 2008 Apr 15;16(8):4661-9. DMMLCSG RU https://pubmed.ncbi.nlm.nih.gov/18296055 DMCH6R1 DI DMCH6R1 DMCH6R1 DN 1-(4-Bromo-2,5-dimethoxy-phenyl)-piperazine DMCH6R1 MI TTSQIFT DMCH6R1 MN 5-HT 1A receptor (HTR1A) DMCH6R1 MT DTT DMCH6R1 MA Inhibitor DMCH6R1 RN Synthesis and evaluation of phenyl- and benzoylpiperazines as potential serotonergic agents. J Med Chem. 1986 May;29(5):630-4. DMCH6R1 RU https://pubmed.ncbi.nlm.nih.gov/3701781 DMCH6R1 DI DMCH6R1 DMCH6R1 DN 1-(4-Bromo-2,5-dimethoxy-phenyl)-piperazine DMCH6R1 MI TT6MSOK DMCH6R1 MN 5-HT 1D receptor (HTR1D) DMCH6R1 MT DTT DMCH6R1 MA Inhibitor DMCH6R1 RN Synthesis and evaluation of phenyl- and benzoylpiperazines as potential serotonergic agents. J Med Chem. 1986 May;29(5):630-4. DMCH6R1 RU https://pubmed.ncbi.nlm.nih.gov/3701781 DMCH6R1 DI DMCH6R1 DMCH6R1 DN 1-(4-Bromo-2,5-dimethoxy-phenyl)-piperazine DMCH6R1 MI TTJQOD7 DMCH6R1 MN 5-HT 2A receptor (HTR2A) DMCH6R1 MT DTT DMCH6R1 MA Inhibitor DMCH6R1 RN Synthesis and evaluation of phenyl- and benzoylpiperazines as potential serotonergic agents. J Med Chem. 1986 May;29(5):630-4. DMCH6R1 RU https://pubmed.ncbi.nlm.nih.gov/3701781 DM2C7U0 DI DM2C7U0 DM2C7U0 DN 1-(4-Bromobenzyl)-1H-imidazole DM2C7U0 MI TTIQUX7 DM2C7U0 MN Steroid 11-beta-hydroxylase (CYP11B1) DM2C7U0 MT DTT DM2C7U0 MA Inhibitor DM2C7U0 RN Synthesis, biological evaluation, and molecular modeling of 1-benzyl-1H-imidazoles as selective inhibitors of aldosterone synthase (CYP11B2). J Med Chem. 2010 Feb 25;53(4):1712-25. DM2C7U0 RU https://pubmed.ncbi.nlm.nih.gov/20121113 DM2C7U0 DI DM2C7U0 DM2C7U0 DN 1-(4-Bromobenzyl)-1H-imidazole DM2C7U0 MI TTRA5BZ DM2C7U0 MN Steroid 17-alpha-monooxygenase (S17AH) DM2C7U0 MT DTT DM2C7U0 MA Inhibitor DM2C7U0 RN Synthesis, biochemical evaluation and rationalisation of the inhibitory activity of a range of 4-substituted phenyl alkyl imidazole-based inhibitor... Bioorg Med Chem Lett. 2006 Sep 15;16(18):4752-6. DM2C7U0 RU https://pubmed.ncbi.nlm.nih.gov/16870430 DMTPD4R DI DMTPD4R DMTPD4R DN 1-(4-Bromo-benzyl)-3-quinazolin-8-yl-urea DMTPD4R MI TTMI6F5 DMTPD4R MN Transient receptor potential cation channel V1 (TRPV1) DMTPD4R MT DTT DMTPD4R MA Inhibitor DMTPD4R RN Novel transient receptor potential vanilloid 1 receptor antagonists for the treatment of pain: structure-activity relationships for ureas with quin... J Med Chem. 2005 Feb 10;48(3):744-52. DMTPD4R RU https://pubmed.ncbi.nlm.nih.gov/15689158 DMCW8RT DI DMCW8RT DMCW8RT DN 1-(4-Bromobenzyl)-5-phenyl-1H-imidazole DMCW8RT MI TTIQUX7 DMCW8RT MN Steroid 11-beta-hydroxylase (CYP11B1) DMCW8RT MT DTT DMCW8RT MA Inhibitor DMCW8RT RN Synthesis, biological evaluation, and molecular modeling of 1-benzyl-1H-imidazoles as selective inhibitors of aldosterone synthase (CYP11B2). J Med Chem. 2010 Feb 25;53(4):1712-25. DMCW8RT RU https://pubmed.ncbi.nlm.nih.gov/20121113 DMUMNYZ DI DMUMNYZ DMUMNYZ DN 1-(4-bromooxazol-2-yl)-7-phenylheptan-1-one DMUMNYZ MI TTDP1UC DMUMNYZ MN Fatty acid amide hydrolase (FAAH) DMUMNYZ MT DTT DMUMNYZ MA Inhibitor DMUMNYZ RN Exploration of a fundamental substituent effect of alpha-ketoheterocycle enzyme inhibitors: Potent and selective inhibitors of fatty acid amide hyd... Bioorg Med Chem Lett. 2008 Nov 15;18(22):5842-6. DMUMNYZ RU https://pubmed.ncbi.nlm.nih.gov/18639454 DME8B15 DI DME8B15 DME8B15 DN 1-(4-bromophenethyl)-1H-imidazole DME8B15 MI TTRA5BZ DME8B15 MN Steroid 17-alpha-monooxygenase (S17AH) DME8B15 MT DTT DME8B15 MA Inhibitor DME8B15 RN Synthesis, biochemical evaluation and rationalisation of the inhibitory activity of a range of 4-substituted phenyl alkyl imidazole-based inhibitor... Bioorg Med Chem Lett. 2006 Sep 15;16(18):4752-6. DME8B15 RU https://pubmed.ncbi.nlm.nih.gov/16870430 DMW6YDK DI DMW6YDK DMW6YDK DN 1-(4-bromophenyl)-2-(tert-butylamino)propan-1-one DMW6YDK MI TTVBI8W DMW6YDK MN Dopamine transporter (DAT) DMW6YDK MT DTT DMW6YDK MA Inhibitor DMW6YDK RN Synthesis and biological evaluation of bupropion analogues as potential pharmacotherapies for smoking cessation. J Med Chem. 2010 Mar 11;53(5):2204-14. DMW6YDK RU https://pubmed.ncbi.nlm.nih.gov/20158204 DMW6YDK DI DMW6YDK DMW6YDK DN 1-(4-bromophenyl)-2-(tert-butylamino)propan-1-one DMW6YDK MI TTAWNKZ DMW6YDK MN Norepinephrine transporter (NET) DMW6YDK MT DTT DMW6YDK MA Inhibitor DMW6YDK RN Synthesis and biological evaluation of bupropion analogues as potential pharmacotherapies for smoking cessation. J Med Chem. 2010 Mar 11;53(5):2204-14. DMW6YDK RU https://pubmed.ncbi.nlm.nih.gov/20158204 DMW6YDK DI DMW6YDK DMW6YDK DN 1-(4-bromophenyl)-2-(tert-butylamino)propan-1-one DMW6YDK MI TT3ROYC DMW6YDK MN Serotonin transporter (SERT) DMW6YDK MT DTT DMW6YDK MA Inhibitor DMW6YDK RN Synthesis and biological evaluation of bupropion analogues as potential pharmacotherapies for smoking cessation. J Med Chem. 2010 Mar 11;53(5):2204-14. DMW6YDK RU https://pubmed.ncbi.nlm.nih.gov/20158204 DMPLEC0 DI DMPLEC0 DMPLEC0 DN 1-(4-bromophenyl)-2-pyrrolidin-1-yl-pentan-1-one DMPLEC0 MI TTVBI8W DMPLEC0 MN Dopamine transporter (DAT) DMPLEC0 MT DTT DMPLEC0 MA Inhibitor DMPLEC0 RN 1-(4-Methylphenyl)-2-pyrrolidin-1-yl-pentan-1-one (Pyrovalerone) analogues: a promising class of monoamine uptake inhibitors. J Med Chem. 2006 Feb 23;49(4):1420-32. DMPLEC0 RU https://pubmed.ncbi.nlm.nih.gov/16480278 DMPLEC0 DI DMPLEC0 DMPLEC0 DN 1-(4-bromophenyl)-2-pyrrolidin-1-yl-pentan-1-one DMPLEC0 MI TTAWNKZ DMPLEC0 MN Norepinephrine transporter (NET) DMPLEC0 MT DTT DMPLEC0 MA Inhibitor DMPLEC0 RN 1-(4-Methylphenyl)-2-pyrrolidin-1-yl-pentan-1-one (Pyrovalerone) analogues: a promising class of monoamine uptake inhibitors. J Med Chem. 2006 Feb 23;49(4):1420-32. DMPLEC0 RU https://pubmed.ncbi.nlm.nih.gov/16480278 DMPLEC0 DI DMPLEC0 DMPLEC0 DN 1-(4-bromophenyl)-2-pyrrolidin-1-yl-pentan-1-one DMPLEC0 MI TT3ROYC DMPLEC0 MN Serotonin transporter (SERT) DMPLEC0 MT DTT DMPLEC0 MA Inhibitor DMPLEC0 RN 1-(4-Methylphenyl)-2-pyrrolidin-1-yl-pentan-1-one (Pyrovalerone) analogues: a promising class of monoamine uptake inhibitors. J Med Chem. 2006 Feb 23;49(4):1420-32. DMPLEC0 RU https://pubmed.ncbi.nlm.nih.gov/16480278 DMEUHDL DI DMEUHDL DMEUHDL DN 1-(4-bromophenyl)-3-hydroxyurea DMEUHDL MI TTULVH8 DMEUHDL MN Tyrosinase (TYR) DMEUHDL MT DTT DMEUHDL MA Inhibitor DMEUHDL RN Analogues of N-hydroxy-N'-phenylthiourea and N-hydroxy-N'-phenylurea as inhibitors of tyrosinase and melanin formation. Bioorg Med Chem Lett. 2008 Jun 15;18(12):3607-10. DMEUHDL RU https://pubmed.ncbi.nlm.nih.gov/18501598 DMOEGZV DI DMOEGZV DMOEGZV DN 1-(4-Butoxy-phenyl)-1H-imidazole DMOEGZV MI TTXV4FI DMOEGZV MN Albendazole monooxygenase (CYP3A4) DMOEGZV MT DTT DMOEGZV MA Inhibitor DMOEGZV RN Imidazole derivatives as new potent and selective 20-HETE synthase inhibitors. Bioorg Med Chem Lett. 2004 Jan 19;14(2):333-6. DMOEGZV RU https://pubmed.ncbi.nlm.nih.gov/14698153 DMOEGZV DI DMOEGZV DMOEGZV DN 1-(4-Butoxy-phenyl)-1H-imidazole DMOEGZV MI TTVG215 DMOEGZV MN Debrisoquine 4-hydroxylase (CYP2D6) DMOEGZV MT DTT DMOEGZV MA Inhibitor DMOEGZV RN Imidazole derivatives as new potent and selective 20-HETE synthase inhibitors. Bioorg Med Chem Lett. 2004 Jan 19;14(2):333-6. DMOEGZV RU https://pubmed.ncbi.nlm.nih.gov/14698153 DM7GIZL DI DM7GIZL DM7GIZL DN 1-(4-butoxyphenyl)propan-2-amine DM7GIZL MI TT3WG5C DM7GIZL MN Monoamine oxidase type A (MAO-A) DM7GIZL MT DTT DM7GIZL MA Inhibitor DM7GIZL RN Naphthylisopropylamine and N-benzylamphetamine derivatives as monoamine oxidase inhibitors. Bioorg Med Chem. 2009 Mar 15;17(6):2452-60. DM7GIZL RU https://pubmed.ncbi.nlm.nih.gov/19243954 DMIGDCK DI DMIGDCK DMIGDCK DN 1-(4-Butyl-thiazol-2-yl)-3-phenethyl-thiourea DMIGDCK MI TT84ETX DMIGDCK MN Human immunodeficiency virus Reverse transcriptase (HIV RT) DMIGDCK MT DTT DMIGDCK MA Inhibitor DMIGDCK RN Phenethylthiazolethiourea (PETT) compounds, a new class of HIV-1 reverse transcriptase inhibitors. 1. Synthesis and basic structure-activity relati... J Med Chem. 1995 Dec 8;38(25):4929-36. DMIGDCK RU https://pubmed.ncbi.nlm.nih.gov/8523406 DMBR9TQ DI DMBR9TQ DMBR9TQ DN 1-(4-chlorobenzyl)-1H-imidazole DMBR9TQ MI TTRA5BZ DMBR9TQ MN Steroid 17-alpha-monooxygenase (S17AH) DMBR9TQ MT DTT DMBR9TQ MA Inhibitor DMBR9TQ RN Synthesis, biochemical evaluation and rationalisation of the inhibitory activity of a range of 4-substituted phenyl alkyl imidazole-based inhibitor... Bioorg Med Chem Lett. 2006 Sep 15;16(18):4752-6. DMBR9TQ RU https://pubmed.ncbi.nlm.nih.gov/16870430 DMOUPNT DI DMOUPNT DMOUPNT DN 1-(4-chlorobenzyl)-1H-indole-2,3-dione DMOUPNT MI TTMF541 DMOUPNT MN Liver carboxylesterase (CES1) DMOUPNT MT DTT DMOUPNT MA Inhibitor DMOUPNT RN Selective inhibition of carboxylesterases by isatins, indole-2,3-diones. J Med Chem. 2007 Apr 19;50(8):1876-85. DMOUPNT RU https://pubmed.ncbi.nlm.nih.gov/17378546 DMASLUF DI DMASLUF DMASLUF DN 1-(4-Chlorobenzyl)-5-phenyl-1H-imidazole DMASLUF MI TTIQUX7 DMASLUF MN Steroid 11-beta-hydroxylase (CYP11B1) DMASLUF MT DTT DMASLUF MA Inhibitor DMASLUF RN Synthesis, biological evaluation, and molecular modeling of 1-benzyl-1H-imidazoles as selective inhibitors of aldosterone synthase (CYP11B2). J Med Chem. 2010 Feb 25;53(4):1712-25. DMASLUF RU https://pubmed.ncbi.nlm.nih.gov/20121113 DMXGB38 DI DMXGB38 DMXGB38 DN 1-(4-chlorooxazol-2-yl)-7-phenylheptan-1-one DMXGB38 MI TTDP1UC DMXGB38 MN Fatty acid amide hydrolase (FAAH) DMXGB38 MT DTT DMXGB38 MA Inhibitor DMXGB38 RN Exploration of a fundamental substituent effect of alpha-ketoheterocycle enzyme inhibitors: Potent and selective inhibitors of fatty acid amide hyd... Bioorg Med Chem Lett. 2008 Nov 15;18(22):5842-6. DMXGB38 RU https://pubmed.ncbi.nlm.nih.gov/18639454 DM9MDZG DI DM9MDZG DM9MDZG DN 1-(4-chlorophenethyl)-1H-imidazole DM9MDZG MI TTRA5BZ DM9MDZG MN Steroid 17-alpha-monooxygenase (S17AH) DM9MDZG MT DTT DM9MDZG MA Inhibitor DM9MDZG RN Synthesis, biochemical evaluation and rationalisation of the inhibitory activity of a range of 4-substituted phenyl alkyl imidazole-based inhibitor... Bioorg Med Chem Lett. 2006 Sep 15;16(18):4752-6. DM9MDZG RU https://pubmed.ncbi.nlm.nih.gov/16870430 DMV8C7I DI DMV8C7I DMV8C7I DN 1-(4-CHLOROPHENYL)-2-(2,4-DICHLOROPHENYL)-5-(METHYLSULFINYL)-N-(PIPERIDIN-1-YL)-1H-IMIDAZOLE-4-CARBOXAMIDE (ENANTIOMERIC MIX) DMV8C7I MI TT6OEDT DMV8C7I MN Cannabinoid receptor 1 (CB1) DMV8C7I MT DTT DMV8C7I MA Inhibitor DMV8C7I RN Probing the cannabinoid CB1/CB2 receptor subtype selectivity limits of 1,2-diarylimidazole-4-carboxamides by fine-tuning their 5-substitution pattern. Bioorg Med Chem Lett. 2010 May 1;20(9):2770-5. DMV8C7I RU https://pubmed.ncbi.nlm.nih.gov/20363132 DMQHTR4 DI DMQHTR4 DMQHTR4 DN 1-(4-chlorophenyl)-2-(phenylsulfonyl)ethanone DMQHTR4 MI TTN7BL9 DMQHTR4 MN Corticosteroid 11-beta-dehydrogenase 1 (HSD11B1) DMQHTR4 MT DTT DMQHTR4 MA Inhibitor DMQHTR4 RN beta-Keto sulfones as inhibitors of 11beta-hydroxysteroid dehydrogenase type I and the mechanism of action. Bioorg Med Chem. 2007 Jul 1;15(13):4396-405. DMQHTR4 RU https://pubmed.ncbi.nlm.nih.gov/17490884 DMCDV1O DI DMCDV1O DMCDV1O DN 1-(4-Chloro-phenyl)-2-phenyl-ethane-1,2-dione DMCDV1O MI TTMF541 DMCDV1O MN Liver carboxylesterase (CES1) DMCDV1O MT DTT DMCDV1O MA Inhibitor DMCDV1O RN Identification and characterization of novel benzil (diphenylethane-1,2-dione) analogues as inhibitors of mammalian carboxylesterases. J Med Chem. 2005 Apr 21;48(8):2906-15. DMCDV1O RU https://pubmed.ncbi.nlm.nih.gov/15828829 DMOGVZ2 DI DMOGVZ2 DMOGVZ2 DN 1-(4-Chloro-phenyl)-2-p-tolyl-ethane-1,2-dione DMOGVZ2 MI TTMF541 DMOGVZ2 MN Liver carboxylesterase (CES1) DMOGVZ2 MT DTT DMOGVZ2 MA Inhibitor DMOGVZ2 RN Identification and characterization of novel benzil (diphenylethane-1,2-dione) analogues as inhibitors of mammalian carboxylesterases. J Med Chem. 2005 Apr 21;48(8):2906-15. DMOGVZ2 RU https://pubmed.ncbi.nlm.nih.gov/15828829 DM3YI5G DI DM3YI5G DM3YI5G DN 1-(4-Chloro-phenyl)-3-(3,3-diphenyl-allyl)-urea DM3YI5G MI TTCG0AL DM3YI5G MN Cholecystokinin receptor type A (CCKAR) DM3YI5G MT DTT DM3YI5G MA Inhibitor DM3YI5G RN Hybrid cholecystokinin-A antagonists based on molecular modeling of lorglumide and L-364,718. J Med Chem. 1992 Mar 20;35(6):1042-9. DM3YI5G RU https://pubmed.ncbi.nlm.nih.gov/1552499 DMUW1GI DI DMUW1GI DMUW1GI DN 1-(4-Chloro-phenyl)-3-(3-pentyl-oct-2-enyl)-urea DMUW1GI MI TTCG0AL DMUW1GI MN Cholecystokinin receptor type A (CCKAR) DMUW1GI MT DTT DMUW1GI MA Inhibitor DMUW1GI RN Hybrid cholecystokinin-A antagonists based on molecular modeling of lorglumide and L-364,718. J Med Chem. 1992 Mar 20;35(6):1042-9. DMUW1GI RU https://pubmed.ncbi.nlm.nih.gov/1552499 DMVCHSI DI DMVCHSI DMVCHSI DN 1-(4-chlorophenyl)-4-phenyl-1H-imidazole DMVCHSI MI TT1MPAY DMVCHSI MN GABA(A) receptor alpha-1 (GABRA1) DMVCHSI MT DTT DMVCHSI MA Inhibitor DMVCHSI RN Synthesis, pharmacology, and structure-activity relationships of novel imidazolones and pyrrolones as modulators of GABAA receptors. J Med Chem. 2006 Mar 23;49(6):1855-66. DMVCHSI RU https://pubmed.ncbi.nlm.nih.gov/16539371 DMVCHSI DI DMVCHSI DMVCHSI DN 1-(4-chlorophenyl)-4-phenyl-1H-imidazole DMVCHSI MI TTZA1NY DMVCHSI MN GABA(A) receptor beta-2 (GABRB2) DMVCHSI MT DTT DMVCHSI MA Inhibitor DMVCHSI RN Synthesis, pharmacology, and structure-activity relationships of novel imidazolones and pyrrolones as modulators of GABAA receptors. J Med Chem. 2006 Mar 23;49(6):1855-66. DMVCHSI RU https://pubmed.ncbi.nlm.nih.gov/16539371 DMVCHSI DI DMVCHSI DMVCHSI DN 1-(4-chlorophenyl)-4-phenyl-1H-imidazole DMVCHSI MI TT06RH5 DMVCHSI MN GABA(A) receptor gamma-2 (GABRG2) DMVCHSI MT DTT DMVCHSI MA Inhibitor DMVCHSI RN Synthesis, pharmacology, and structure-activity relationships of novel imidazolones and pyrrolones as modulators of GABAA receptors. J Med Chem. 2006 Mar 23;49(6):1855-66. DMVCHSI RU https://pubmed.ncbi.nlm.nih.gov/16539371 DMVCHSI DI DMVCHSI DMVCHSI DN 1-(4-chlorophenyl)-4-phenyl-1H-imidazole DMVCHSI MI TTNJYV2 DMVCHSI MN Gamma-aminobutyric acid receptor (GAR) DMVCHSI MT DTT DMVCHSI MA Inhibitor DMVCHSI RN Synthesis, pharmacology, and structure-activity relationships of novel imidazolones and pyrrolones as modulators of GABAA receptors. J Med Chem. 2006 Mar 23;49(6):1855-66. DMVCHSI RU https://pubmed.ncbi.nlm.nih.gov/16539371 DMEJXWG DI DMEJXWG DMEJXWG DN 1-(4-chlorophenylsulfonyl)-4-phenylazepan-4-ol DMEJXWG MI TTN7BL9 DMEJXWG MN Corticosteroid 11-beta-dehydrogenase 1 (HSD11B1) DMEJXWG MT DTT DMEJXWG MA Inhibitor DMEJXWG RN The discovery of azepane sulfonamides as potent 11beta-HSD1 inhibitors. Bioorg Med Chem Lett. 2009 Aug 15;19(16):4563-5. DMEJXWG RU https://pubmed.ncbi.nlm.nih.gov/19625185 DMIU3C8 DI DMIU3C8 DMIU3C8 DN 1-(4-cyano-2-hydroxyphenyl)-3-phenylurea DMIU3C8 MI TT30C9G DMIU3C8 MN C-X-C chemokine receptor type 2 (CXCR2) DMIU3C8 MT DTT DMIU3C8 MA Inhibitor DMIU3C8 RN Comparison of N,N'-diarylsquaramides and N,N'-diarylureas as antagonists of the CXCR2 chemokine receptor. Bioorg Med Chem Lett. 2007 Mar 15;17(6):1713-7. DMIU3C8 RU https://pubmed.ncbi.nlm.nih.gov/17236763 DMKDAJ2 DI DMKDAJ2 DMKDAJ2 DN 1-(4-Cyanobenzyl)-5-(2-fluorophenyl)-1H-imidazole DMKDAJ2 MI TTIQUX7 DMKDAJ2 MN Steroid 11-beta-hydroxylase (CYP11B1) DMKDAJ2 MT DTT DMKDAJ2 MA Inhibitor DMKDAJ2 RN Synthesis, biological evaluation, and molecular modeling of 1-benzyl-1H-imidazoles as selective inhibitors of aldosterone synthase (CYP11B2). J Med Chem. 2010 Feb 25;53(4):1712-25. DMKDAJ2 RU https://pubmed.ncbi.nlm.nih.gov/20121113 DMAJXYO DI DMAJXYO DMAJXYO DN 1-(4-Cyanobenzyl)-5-(2-methylphenyl)-1H-imidazole DMAJXYO MI TTIQUX7 DMAJXYO MN Steroid 11-beta-hydroxylase (CYP11B1) DMAJXYO MT DTT DMAJXYO MA Inhibitor DMAJXYO RN Synthesis, biological evaluation, and molecular modeling of 1-benzyl-1H-imidazoles as selective inhibitors of aldosterone synthase (CYP11B2). J Med Chem. 2010 Feb 25;53(4):1712-25. DMAJXYO RU https://pubmed.ncbi.nlm.nih.gov/20121113 DMVS4D5 DI DMVS4D5 DMVS4D5 DN 1-(4-Cyanobenzyl)-5-(3-fluorophenyl)-1H-imidazole DMVS4D5 MI TTIQUX7 DMVS4D5 MN Steroid 11-beta-hydroxylase (CYP11B1) DMVS4D5 MT DTT DMVS4D5 MA Inhibitor DMVS4D5 RN Synthesis, biological evaluation, and molecular modeling of 1-benzyl-1H-imidazoles as selective inhibitors of aldosterone synthase (CYP11B2). J Med Chem. 2010 Feb 25;53(4):1712-25. DMVS4D5 RU https://pubmed.ncbi.nlm.nih.gov/20121113 DMI8UC7 DI DMI8UC7 DMI8UC7 DN 1-(4-Cyanobenzyl)-5-(3-methylphenyl)-1H-imidazole DMI8UC7 MI TTIQUX7 DMI8UC7 MN Steroid 11-beta-hydroxylase (CYP11B1) DMI8UC7 MT DTT DMI8UC7 MA Inhibitor DMI8UC7 RN Synthesis, biological evaluation, and molecular modeling of 1-benzyl-1H-imidazoles as selective inhibitors of aldosterone synthase (CYP11B2). J Med Chem. 2010 Feb 25;53(4):1712-25. DMI8UC7 RU https://pubmed.ncbi.nlm.nih.gov/20121113 DM7C3VD DI DM7C3VD DM7C3VD DN 1-(4-Cyanobenzyl)-5-(4-fluorophenyl)-1H-imidazole DM7C3VD MI TTIQUX7 DM7C3VD MN Steroid 11-beta-hydroxylase (CYP11B1) DM7C3VD MT DTT DM7C3VD MA Inhibitor DM7C3VD RN Synthesis, biological evaluation, and molecular modeling of 1-benzyl-1H-imidazoles as selective inhibitors of aldosterone synthase (CYP11B2). J Med Chem. 2010 Feb 25;53(4):1712-25. DM7C3VD RU https://pubmed.ncbi.nlm.nih.gov/20121113 DMQX37R DI DMQX37R DMQX37R DN 1-(4-Cyanobenzyl)-5-(4-methylphenyl)-1H-imidazole DMQX37R MI TTIQUX7 DMQX37R MN Steroid 11-beta-hydroxylase (CYP11B1) DMQX37R MT DTT DMQX37R MA Inhibitor DMQX37R RN Synthesis, biological evaluation, and molecular modeling of 1-benzyl-1H-imidazoles as selective inhibitors of aldosterone synthase (CYP11B2). J Med Chem. 2010 Feb 25;53(4):1712-25. DMQX37R RU https://pubmed.ncbi.nlm.nih.gov/20121113 DM372EG DI DM372EG DM372EG DN 1-(4-Cyanobenzyl)-5-(4-pyridyl)-1H-imidazole DM372EG MI TTIQUX7 DM372EG MN Steroid 11-beta-hydroxylase (CYP11B1) DM372EG MT DTT DM372EG MA Inhibitor DM372EG RN Synthesis, biological evaluation, and molecular modeling of 1-benzyl-1H-imidazoles as selective inhibitors of aldosterone synthase (CYP11B2). J Med Chem. 2010 Feb 25;53(4):1712-25. DM372EG RU https://pubmed.ncbi.nlm.nih.gov/20121113 DMBUMDG DI DMBUMDG DMBUMDG DN 1-(4-Cyanobenzyl)-5-bromo-1H-imidazole DMBUMDG MI TTIQUX7 DMBUMDG MN Steroid 11-beta-hydroxylase (CYP11B1) DMBUMDG MT DTT DMBUMDG MA Inhibitor DMBUMDG RN Synthesis, biological evaluation, and molecular modeling of 1-benzyl-1H-imidazoles as selective inhibitors of aldosterone synthase (CYP11B2). J Med Chem. 2010 Feb 25;53(4):1712-25. DMBUMDG RU https://pubmed.ncbi.nlm.nih.gov/20121113 DM2THVK DI DM2THVK DM2THVK DN 1-(4-Cyanobenzyl)-5-formyl-1H-imidazole DM2THVK MI TTIQUX7 DM2THVK MN Steroid 11-beta-hydroxylase (CYP11B1) DM2THVK MT DTT DM2THVK MA Inhibitor DM2THVK RN Synthesis, biological evaluation, and molecular modeling of 1-benzyl-1H-imidazoles as selective inhibitors of aldosterone synthase (CYP11B2). J Med Chem. 2010 Feb 25;53(4):1712-25. DM2THVK RU https://pubmed.ncbi.nlm.nih.gov/20121113 DMCUE25 DI DMCUE25 DMCUE25 DN 1-(4-Cyanobenzyl)-5-hydroxymethyl-1H-imidazole DMCUE25 MI TTIQUX7 DMCUE25 MN Steroid 11-beta-hydroxylase (CYP11B1) DMCUE25 MT DTT DMCUE25 MA Inhibitor DMCUE25 RN Synthesis, biological evaluation, and molecular modeling of 1-benzyl-1H-imidazoles as selective inhibitors of aldosterone synthase (CYP11B2). J Med Chem. 2010 Feb 25;53(4):1712-25. DMCUE25 RU https://pubmed.ncbi.nlm.nih.gov/20121113 DMKC52N DI DMKC52N DMKC52N DN 1-(4-Cyanobenzyl)-5-methyl-1H-imidazole DMKC52N MI TTSZLWK DMKC52N MN Aromatase (CYP19A1) DMKC52N MT DTT DMKC52N MA Inhibitor DMKC52N RN Fadrozole hydrochloride: a potent, selective, nonsteroidal inhibitor of aromatase for the treatment of estrogen-dependent disease. J Med Chem. 1991 Feb;34(2):725-36. DMKC52N RU https://pubmed.ncbi.nlm.nih.gov/1825337 DMKC52N DI DMKC52N DMKC52N DN 1-(4-Cyanobenzyl)-5-methyl-1H-imidazole DMKC52N MI TTIQUX7 DMKC52N MN Steroid 11-beta-hydroxylase (CYP11B1) DMKC52N MT DTT DMKC52N MA Inhibitor DMKC52N RN Synthesis, biological evaluation, and molecular modeling of 1-benzyl-1H-imidazoles as selective inhibitors of aldosterone synthase (CYP11B2). J Med Chem. 2010 Feb 25;53(4):1712-25. DMKC52N RU https://pubmed.ncbi.nlm.nih.gov/20121113 DMQF8DY DI DMQF8DY DMQF8DY DN 1-(4-Cyanobenzyl)-5-phenyl-1H-imidazole DMQF8DY MI TTIQUX7 DMQF8DY MN Steroid 11-beta-hydroxylase (CYP11B1) DMQF8DY MT DTT DMQF8DY MA Inhibitor DMQF8DY RN Synthesis, biological evaluation, and molecular modeling of 1-benzyl-1H-imidazoles as selective inhibitors of aldosterone synthase (CYP11B2). J Med Chem. 2010 Feb 25;53(4):1712-25. DMQF8DY RU https://pubmed.ncbi.nlm.nih.gov/20121113 DM9EK3T DI DM9EK3T DM9EK3T DN 1-(4-Cyano-thiazol-2-yl)-3-phenethyl-thiourea DM9EK3T MI TT84ETX DM9EK3T MN Human immunodeficiency virus Reverse transcriptase (HIV RT) DM9EK3T MT DTT DM9EK3T MA Inhibitor DM9EK3T RN Phenethylthiazolethiourea (PETT) compounds, a new class of HIV-1 reverse transcriptase inhibitors. 1. Synthesis and basic structure-activity relati... J Med Chem. 1995 Dec 8;38(25):4929-36. DM9EK3T RU https://pubmed.ncbi.nlm.nih.gov/8523406 DMZR94D DI DMZR94D DMZR94D DN 1-(4-ethoxyphenyl)propan-2-amine DMZR94D MI TT3WG5C DMZR94D MN Monoamine oxidase type A (MAO-A) DMZR94D MT DTT DMZR94D MA Inhibitor DMZR94D RN Naphthylisopropylamine and N-benzylamphetamine derivatives as monoamine oxidase inhibitors. Bioorg Med Chem. 2009 Mar 15;17(6):2452-60. DMZR94D RU https://pubmed.ncbi.nlm.nih.gov/19243954 DMIYLXU DI DMIYLXU DMIYLXU DN 1-(4-ethyl-2,5-dimethoxyphenyl)propan-2-amine DMIYLXU MI TTJQOD7 DMIYLXU MN 5-HT 2A receptor (HTR2A) DMIYLXU MT DTT DMIYLXU MA Inhibitor DMIYLXU RN The role of lipophilicity in determining binding affinity and functional activity for 5-HT2A receptor ligands. Bioorg Med Chem. 2008 Apr 15;16(8):4661-9. DMIYLXU RU https://pubmed.ncbi.nlm.nih.gov/18296055 DMXUIS2 DI DMXUIS2 DMXUIS2 DN 1-(4-ethylphenylsulfonyl)-4-phenylazepan-4-ol DMXUIS2 MI TTN7BL9 DMXUIS2 MN Corticosteroid 11-beta-dehydrogenase 1 (HSD11B1) DMXUIS2 MT DTT DMXUIS2 MA Inhibitor DMXUIS2 RN The discovery of azepane sulfonamides as potent 11beta-HSD1 inhibitors. Bioorg Med Chem Lett. 2009 Aug 15;19(16):4563-5. DMXUIS2 RU https://pubmed.ncbi.nlm.nih.gov/19625185 DMRK0Z1 DI DMRK0Z1 DMRK0Z1 DN 1-(4-ethylpiperazin-1-yl)-2-phenylethanone DMRK0Z1 MI TTN7BL9 DMRK0Z1 MN Corticosteroid 11-beta-dehydrogenase 1 (HSD11B1) DMRK0Z1 MT DTT DMRK0Z1 MA Inhibitor DMRK0Z1 RN Discovery and biological evaluation of adamantyl amide 11beta-HSD1 inhibitors. Bioorg Med Chem Lett. 2007 May 15;17(10):2838-43. DMRK0Z1 RU https://pubmed.ncbi.nlm.nih.gov/17350260 DMBJCGA DI DMBJCGA DMBJCGA DN 1-(4-fluorobenzyl)-1H-imidazole DMBJCGA MI TTIQUX7 DMBJCGA MN Steroid 11-beta-hydroxylase (CYP11B1) DMBJCGA MT DTT DMBJCGA MA Inhibitor DMBJCGA RN Synthesis, biological evaluation, and molecular modeling of 1-benzyl-1H-imidazoles as selective inhibitors of aldosterone synthase (CYP11B2). J Med Chem. 2010 Feb 25;53(4):1712-25. DMBJCGA RU https://pubmed.ncbi.nlm.nih.gov/20121113 DMBJCGA DI DMBJCGA DMBJCGA DN 1-(4-fluorobenzyl)-1H-imidazole DMBJCGA MI TTRA5BZ DMBJCGA MN Steroid 17-alpha-monooxygenase (S17AH) DMBJCGA MT DTT DMBJCGA MA Inhibitor DMBJCGA RN Synthesis, biochemical evaluation and rationalisation of the inhibitory activity of a range of 4-substituted phenyl alkyl imidazole-based inhibitor... Bioorg Med Chem Lett. 2006 Sep 15;16(18):4752-6. DMBJCGA RU https://pubmed.ncbi.nlm.nih.gov/16870430 DMT2ZSV DI DMT2ZSV DMT2ZSV DN 1-(4-Fluorobenzyl)-5-phenyl-1H-imidazole DMT2ZSV MI TTIQUX7 DMT2ZSV MN Steroid 11-beta-hydroxylase (CYP11B1) DMT2ZSV MT DTT DMT2ZSV MA Inhibitor DMT2ZSV RN Synthesis, biological evaluation, and molecular modeling of 1-benzyl-1H-imidazoles as selective inhibitors of aldosterone synthase (CYP11B2). J Med Chem. 2010 Feb 25;53(4):1712-25. DMT2ZSV RU https://pubmed.ncbi.nlm.nih.gov/20121113 DMZLNAP DI DMZLNAP DMZLNAP DN 1-(4-fluorophenyl)-2-(phenylsulfonyl)ethanone DMZLNAP MI TTN7BL9 DMZLNAP MN Corticosteroid 11-beta-dehydrogenase 1 (HSD11B1) DMZLNAP MT DTT DMZLNAP MA Inhibitor DMZLNAP RN beta-Keto sulfones as inhibitors of 11beta-hydroxysteroid dehydrogenase type I and the mechanism of action. Bioorg Med Chem. 2007 Jul 1;15(13):4396-405. DMZLNAP RU https://pubmed.ncbi.nlm.nih.gov/17490884 DM6ARQF DI DM6ARQF DM6ARQF DN 1-(4-fluorophenyl)-2-pyrrolidin-1-yl-pentan-1-one DM6ARQF MI TTVBI8W DM6ARQF MN Dopamine transporter (DAT) DM6ARQF MT DTT DM6ARQF MA Inhibitor DM6ARQF RN 1-(4-Methylphenyl)-2-pyrrolidin-1-yl-pentan-1-one (Pyrovalerone) analogues: a promising class of monoamine uptake inhibitors. J Med Chem. 2006 Feb 23;49(4):1420-32. DM6ARQF RU https://pubmed.ncbi.nlm.nih.gov/16480278 DM6ARQF DI DM6ARQF DM6ARQF DN 1-(4-fluorophenyl)-2-pyrrolidin-1-yl-pentan-1-one DM6ARQF MI TTAWNKZ DM6ARQF MN Norepinephrine transporter (NET) DM6ARQF MT DTT DM6ARQF MA Inhibitor DM6ARQF RN 1-(4-Methylphenyl)-2-pyrrolidin-1-yl-pentan-1-one (Pyrovalerone) analogues: a promising class of monoamine uptake inhibitors. J Med Chem. 2006 Feb 23;49(4):1420-32. DM6ARQF RU https://pubmed.ncbi.nlm.nih.gov/16480278 DMKATOJ DI DMKATOJ DMKATOJ DN 1-(4-fluorophenyl)-3-(phenylsulfonyl)propan-1-one DMKATOJ MI TTN7BL9 DMKATOJ MN Corticosteroid 11-beta-dehydrogenase 1 (HSD11B1) DMKATOJ MT DTT DMKATOJ MA Inhibitor DMKATOJ RN beta-Keto sulfones as inhibitors of 11beta-hydroxysteroid dehydrogenase type I and the mechanism of action. Bioorg Med Chem. 2007 Jul 1;15(13):4396-405. DMKATOJ RU https://pubmed.ncbi.nlm.nih.gov/17490884 DMIQ0VA DI DMIQ0VA DMIQ0VA DN 1-(4-heptylphenyl)prop-2-en-1-one DMIQ0VA MI TTGER3L DMIQ0VA MN Thyroid hormone receptor beta (THRB) DMIQ0VA MT DTT DMIQ0VA MA Inhibitor DMIQ0VA RN Inhibitors of the interaction of a thyroid hormone receptor and coactivators: preliminary structure-activity relationships. J Med Chem. 2007 Nov 1;50(22):5269-80. DMIQ0VA RU https://pubmed.ncbi.nlm.nih.gov/17918822 DM5QLGH DI DM5QLGH DM5QLGH DN 1-(4-hexylphenyl)-3-(propylamino)propan-1-one DM5QLGH MI TTGER3L DM5QLGH MN Thyroid hormone receptor beta (THRB) DM5QLGH MT DTT DM5QLGH MA Inhibitor DM5QLGH RN Inhibitors of the interaction of a thyroid hormone receptor and coactivators: preliminary structure-activity relationships. J Med Chem. 2007 Nov 1;50(22):5269-80. DM5QLGH RU https://pubmed.ncbi.nlm.nih.gov/17918822 DMFN8T6 DI DMFN8T6 DMFN8T6 DN 1-(4-hexylphenyl)-3-morpholinopropan-1-one DMFN8T6 MI TTTSEPU DMFN8T6 MN Thyroid hormone receptor alpha (THRA) DMFN8T6 MT DTT DMFN8T6 MA Inhibitor DMFN8T6 RN Inhibitors of the interaction of a thyroid hormone receptor and coactivators: preliminary structure-activity relationships. J Med Chem. 2007 Nov 1;50(22):5269-80. DMFN8T6 RU https://pubmed.ncbi.nlm.nih.gov/17918822 DMFN8T6 DI DMFN8T6 DMFN8T6 DN 1-(4-hexylphenyl)-3-morpholinopropan-1-one DMFN8T6 MI TTGER3L DMFN8T6 MN Thyroid hormone receptor beta (THRB) DMFN8T6 MT DTT DMFN8T6 MA Inhibitor DMFN8T6 RN Inhibitors of the interaction of a thyroid hormone receptor and coactivators: preliminary structure-activity relationships. J Med Chem. 2007 Nov 1;50(22):5269-80. DMFN8T6 RU https://pubmed.ncbi.nlm.nih.gov/17918822 DMX7PJH DI DMX7PJH DMX7PJH DN 1-(4-HEXYLPHENYL)PROP-2-EN-1-ONE DMX7PJH MI TTGER3L DMX7PJH MN Thyroid hormone receptor beta (THRB) DMX7PJH MT DTT DMX7PJH MA Inhibitor DMX7PJH RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DMX7PJH RU https://pubmed.ncbi.nlm.nih.gov/10592235 DM145QS DI DM145QS DM145QS DN 1-(4-hydroxyphenyl)prop-2-en-1-one DM145QS MI TTT2LD9 DM145QS MN GABA transaminase (ABAT) DM145QS MT DTT DM145QS MA Inhibitor DM145QS RN Inhibition of GABA shunt enzymes' activity by 4-hydroxybenzaldehyde derivatives. Bioorg Med Chem Lett. 2006 Feb;16(3):592-5. DM145QS RU https://pubmed.ncbi.nlm.nih.gov/16290145 DM145QS DI DM145QS DM145QS DN 1-(4-hydroxyphenyl)prop-2-en-1-one DM145QS MI TTJUWVB DM145QS MN Succinate-semialdehyde dehydrogenase (ALDH5A1) DM145QS MT DTT DM145QS MA Inhibitor DM145QS RN Inhibition of GABA shunt enzymes' activity by 4-hydroxybenzaldehyde derivatives. Bioorg Med Chem Lett. 2006 Feb;16(3):592-5. DM145QS RU https://pubmed.ncbi.nlm.nih.gov/16290145 DMM17I0 DI DMM17I0 DMM17I0 DN 1-(4-iodobenzyl)-1H-imidazole DMM17I0 MI TTRA5BZ DMM17I0 MN Steroid 17-alpha-monooxygenase (S17AH) DMM17I0 MT DTT DMM17I0 MA Inhibitor DMM17I0 RN Synthesis and biochemical evaluation of a range of (4-substituted phenyl)sulfonate derivatives of 4-hydroxybenzyl imidazole-based compounds as pote... Bioorg Med Chem Lett. 2010 Sep 1;20(17):5345-8. DMM17I0 RU https://pubmed.ncbi.nlm.nih.gov/20675132 DMDY93H DI DMDY93H DMDY93H DN 1-(4-iodooxazol-2-yl)-7-phenylheptan-1-one DMDY93H MI TTDP1UC DMDY93H MN Fatty acid amide hydrolase (FAAH) DMDY93H MT DTT DMDY93H MA Inhibitor DMDY93H RN Exploration of a fundamental substituent effect of alpha-ketoheterocycle enzyme inhibitors: Potent and selective inhibitors of fatty acid amide hyd... Bioorg Med Chem Lett. 2008 Nov 15;18(22):5842-6. DMDY93H RU https://pubmed.ncbi.nlm.nih.gov/18639454 DMBV8PT DI DMBV8PT DMBV8PT DN 1-(4-iodophenyl)-2-pyrrolidin-1-yl-pentan-1-one DMBV8PT MI TTVBI8W DMBV8PT MN Dopamine transporter (DAT) DMBV8PT MT DTT DMBV8PT MA Inhibitor DMBV8PT RN 1-(4-Methylphenyl)-2-pyrrolidin-1-yl-pentan-1-one (Pyrovalerone) analogues: a promising class of monoamine uptake inhibitors. J Med Chem. 2006 Feb 23;49(4):1420-32. DMBV8PT RU https://pubmed.ncbi.nlm.nih.gov/16480278 DMBV8PT DI DMBV8PT DMBV8PT DN 1-(4-iodophenyl)-2-pyrrolidin-1-yl-pentan-1-one DMBV8PT MI TTAWNKZ DMBV8PT MN Norepinephrine transporter (NET) DMBV8PT MT DTT DMBV8PT MA Inhibitor DMBV8PT RN 1-(4-Methylphenyl)-2-pyrrolidin-1-yl-pentan-1-one (Pyrovalerone) analogues: a promising class of monoamine uptake inhibitors. J Med Chem. 2006 Feb 23;49(4):1420-32. DMBV8PT RU https://pubmed.ncbi.nlm.nih.gov/16480278 DMBV8PT DI DMBV8PT DMBV8PT DN 1-(4-iodophenyl)-2-pyrrolidin-1-yl-pentan-1-one DMBV8PT MI TT3ROYC DMBV8PT MN Serotonin transporter (SERT) DMBV8PT MT DTT DMBV8PT MA Inhibitor DMBV8PT RN 1-(4-Methylphenyl)-2-pyrrolidin-1-yl-pentan-1-one (Pyrovalerone) analogues: a promising class of monoamine uptake inhibitors. J Med Chem. 2006 Feb 23;49(4):1420-32. DMBV8PT RU https://pubmed.ncbi.nlm.nih.gov/16480278 DMZWRU7 DI DMZWRU7 DMZWRU7 DN 1-(4-Methoxy-benzenesulfonyl)-heptane-3-thiol DMZWRU7 MI TTHY57M DMZWRU7 MN Matrix metalloproteinase-13 (MMP-13) DMZWRU7 MT DTT DMZWRU7 MA Inhibitor DMZWRU7 RN Discovery of a novel series of selective MMP inhibitors: identification of the gamma-sulfone-thiols. Bioorg Med Chem Lett. 1999 Apr 5;9(7):943-8. DMZWRU7 RU https://pubmed.ncbi.nlm.nih.gov/10230616 DMSWJKZ DI DMSWJKZ DMSWJKZ DN 1-(4-Methoxybenzyl)-5-phenyl-1H-imidazole DMSWJKZ MI TTIQUX7 DMSWJKZ MN Steroid 11-beta-hydroxylase (CYP11B1) DMSWJKZ MT DTT DMSWJKZ MA Inhibitor DMSWJKZ RN Synthesis, biological evaluation, and molecular modeling of 1-benzyl-1H-imidazoles as selective inhibitors of aldosterone synthase (CYP11B2). J Med Chem. 2010 Feb 25;53(4):1712-25. DMSWJKZ RU https://pubmed.ncbi.nlm.nih.gov/20121113 DMEPJRD DI DMEPJRD DMEPJRD DN 1-(4-methoxyoxazol-2-yl)-7-phenylheptan-1-one DMEPJRD MI TTDP1UC DMEPJRD MN Fatty acid amide hydrolase (FAAH) DMEPJRD MT DTT DMEPJRD MA Inhibitor DMEPJRD RN Exploration of a fundamental substituent effect of alpha-ketoheterocycle enzyme inhibitors: Potent and selective inhibitors of fatty acid amide hyd... Bioorg Med Chem Lett. 2008 Nov 15;18(22):5842-6. DMEPJRD RU https://pubmed.ncbi.nlm.nih.gov/18639454 DMAW78K DI DMAW78K DMAW78K DN 1-(4-methoxyphenethyl)pyrrolidine DMAW78K MI TT9JNIC DMAW78K MN Histamine H3 receptor (H3R) DMAW78K MT DTT DMAW78K MA Inhibitor DMAW78K RN In vitro SAR of pyrrolidine-containing histamine H3 receptor antagonists: trends across multiple chemical series. Bioorg Med Chem Lett. 2008 Jan 1;18(1):355-9. DMAW78K RU https://pubmed.ncbi.nlm.nih.gov/18077160 DMRC7V8 DI DMRC7V8 DMRC7V8 DN 1-(4-methoxyphenyl)-2-(phenylsulfonyl)ethanone DMRC7V8 MI TTN7BL9 DMRC7V8 MN Corticosteroid 11-beta-dehydrogenase 1 (HSD11B1) DMRC7V8 MT DTT DMRC7V8 MA Inhibitor DMRC7V8 RN beta-Keto sulfones as inhibitors of 11beta-hydroxysteroid dehydrogenase type I and the mechanism of action. Bioorg Med Chem. 2007 Jul 1;15(13):4396-405. DMRC7V8 RU https://pubmed.ncbi.nlm.nih.gov/17490884 DM5R8KU DI DM5R8KU DM5R8KU DN 1-(4-Methoxy-phenyl)-2-phenyl-ethane-1,2-dione DM5R8KU MI TTMF541 DM5R8KU MN Liver carboxylesterase (CES1) DM5R8KU MT DTT DM5R8KU MA Inhibitor DM5R8KU RN Identification and characterization of novel benzil (diphenylethane-1,2-dione) analogues as inhibitors of mammalian carboxylesterases. J Med Chem. 2005 Apr 21;48(8):2906-15. DM5R8KU RU https://pubmed.ncbi.nlm.nih.gov/15828829 DMNJ2CS DI DMNJ2CS DMNJ2CS DN 1-(4-methoxyphenyl)-3-(1,3,4-thiadiazol-2-yl)urea DMNJ2CS MI TTSJ6Q4 DMNJ2CS MN LOX-5 messenger RNA (ALOX5 mRNA) DMNJ2CS MT DTT DMNJ2CS MA Inhibitor DMNJ2CS RN Identification of natural-product-derived inhibitors of 5-lipoxygenase activity by ligand-based virtual screening. J Med Chem. 2007 May 31;50(11):2640-6. DMNJ2CS RU https://pubmed.ncbi.nlm.nih.gov/17461565 DMYPC0W DI DMYPC0W DMYPC0W DN 1-(4-methoxyphenyl)-3-(4-methylthiazol-2-yl)urea DMYPC0W MI TTSJ6Q4 DMYPC0W MN LOX-5 messenger RNA (ALOX5 mRNA) DMYPC0W MT DTT DMYPC0W MA Inhibitor DMYPC0W RN Identification of natural-product-derived inhibitors of 5-lipoxygenase activity by ligand-based virtual screening. J Med Chem. 2007 May 31;50(11):2640-6. DMYPC0W RU https://pubmed.ncbi.nlm.nih.gov/17461565 DMVWIE5 DI DMVWIE5 DMVWIE5 DN 1-(4-methoxyphenyl)-3-(5-methylthiazol-2-yl)urea DMVWIE5 MI TTSJ6Q4 DMVWIE5 MN LOX-5 messenger RNA (ALOX5 mRNA) DMVWIE5 MT DTT DMVWIE5 MA Inhibitor DMVWIE5 RN Identification of natural-product-derived inhibitors of 5-lipoxygenase activity by ligand-based virtual screening. J Med Chem. 2007 May 31;50(11):2640-6. DMVWIE5 RU https://pubmed.ncbi.nlm.nih.gov/17461565 DMG7PKA DI DMG7PKA DMG7PKA DN 1-(4-methoxyphenylsulfonyl)-4-phenylazepan-4-ol DMG7PKA MI TTN7BL9 DMG7PKA MN Corticosteroid 11-beta-dehydrogenase 1 (HSD11B1) DMG7PKA MT DTT DMG7PKA MA Inhibitor DMG7PKA RN The discovery of azepane sulfonamides as potent 11beta-HSD1 inhibitors. Bioorg Med Chem Lett. 2009 Aug 15;19(16):4563-5. DMG7PKA RU https://pubmed.ncbi.nlm.nih.gov/19625185 DMNDJTL DI DMNDJTL DMNDJTL DN 1'-(4-Methyl-benzyl)-[1,4']bipiperidinyl DMNDJTL MI TTULVH8 DMNDJTL MN Tyrosinase (TYR) DMNDJTL MT DTT DMNDJTL MA Inhibitor DMNDJTL RN Dragon method for finding novel tyrosinase inhibitors: Biosilico identification and experimental in vitro assays. Eur J Med Chem. 2007 Nov-Dec;42(11-12):1370-81. DMNDJTL RU https://pubmed.ncbi.nlm.nih.gov/17637486 DM48ISZ DI DM48ISZ DM48ISZ DN 1-(4-methyl-benzyl)-1H-imidazole DM48ISZ MI TTRA5BZ DM48ISZ MN Steroid 17-alpha-monooxygenase (S17AH) DM48ISZ MT DTT DM48ISZ MA Inhibitor DM48ISZ RN Synthesis and biochemical evaluation of a range of potent benzyl imidazole-based compounds as potential inhibitors of the enzyme complex 17alpha-hy... Bioorg Med Chem Lett. 2006 Aug 1;16(15):4011-5. DM48ISZ RU https://pubmed.ncbi.nlm.nih.gov/16750362 DMVI2PM DI DMVI2PM DMVI2PM DN 1-(4-methyloxazol-2-yl)-7-phenylheptan-1-one DMVI2PM MI TTDP1UC DMVI2PM MN Fatty acid amide hydrolase (FAAH) DMVI2PM MT DTT DMVI2PM MA Inhibitor DMVI2PM RN Exploration of a fundamental substituent effect of alpha-ketoheterocycle enzyme inhibitors: Potent and selective inhibitors of fatty acid amide hyd... Bioorg Med Chem Lett. 2008 Nov 15;18(22):5842-6. DMVI2PM RU https://pubmed.ncbi.nlm.nih.gov/18639454 DM3NVLB DI DM3NVLB DM3NVLB DN 1-(4-Methylpent-3-en-2-ylidene)thiosemicarbazide DM3NVLB MI TTULVH8 DM3NVLB MN Tyrosinase (TYR) DM3NVLB MT DTT DM3NVLB MA Inhibitor DM3NVLB RN A class of potent tyrosinase inhibitors: alkylidenethiosemicarbazide compounds. Eur J Med Chem. 2009 Apr;44(4):1773-8. DM3NVLB RU https://pubmed.ncbi.nlm.nih.gov/18524420 DMSRBUE DI DMSRBUE DMSRBUE DN 1-(4-nitro-2-phenoxybenzyl)-1H-imidazole DMSRBUE MI TTSZLWK DMSRBUE MN Aromatase (CYP19A1) DMSRBUE MT DTT DMSRBUE MA Inhibitor DMSRBUE RN Novel highly potent and selective nonsteroidal aromatase inhibitors: synthesis, biological evaluation and structure-activity relationships investigation. J Med Chem. 2010 Jul 22;53(14):5347-51. DMSRBUE RU https://pubmed.ncbi.nlm.nih.gov/20568782 DMCP089 DI DMCP089 DMCP089 DN 1-(4-Nitro-2-phenylsulfanylbenzyl)-1H-imidazole DMCP089 MI TTSZLWK DMCP089 MN Aromatase (CYP19A1) DMCP089 MT DTT DMCP089 MA Inhibitor DMCP089 RN Novel highly potent and selective nonsteroidal aromatase inhibitors: synthesis, biological evaluation and structure-activity relationships investigation. J Med Chem. 2010 Jul 22;53(14):5347-51. DMCP089 RU https://pubmed.ncbi.nlm.nih.gov/20568782 DMKT2MB DI DMKT2MB DMKT2MB DN 1-(4-nitrobenzyl)-1H-imidazole DMKT2MB MI TTRA5BZ DMKT2MB MN Steroid 17-alpha-monooxygenase (S17AH) DMKT2MB MT DTT DMKT2MB MA Inhibitor DMKT2MB RN Synthesis and biochemical evaluation of a range of potent benzyl imidazole-based compounds as potential inhibitors of the enzyme complex 17alpha-hy... Bioorg Med Chem Lett. 2006 Aug 1;16(15):4011-5. DMKT2MB RU https://pubmed.ncbi.nlm.nih.gov/16750362 DMKR8BI DI DMKR8BI DMKR8BI DN 1-(4-nitrophenethyl)pyrrolidine DMKR8BI MI TT9JNIC DMKR8BI MN Histamine H3 receptor (H3R) DMKR8BI MT DTT DMKR8BI MA Inhibitor DMKR8BI RN In vitro SAR of pyrrolidine-containing histamine H3 receptor antagonists: trends across multiple chemical series. Bioorg Med Chem Lett. 2008 Jan 1;18(1):355-9. DMKR8BI RU https://pubmed.ncbi.nlm.nih.gov/18077160 DM1M67Q DI DM1M67Q DM1M67Q DN 1-(4-nitrophenyl)-2-(phenylsulfonyl)ethanone DM1M67Q MI TTN7BL9 DM1M67Q MN Corticosteroid 11-beta-dehydrogenase 1 (HSD11B1) DM1M67Q MT DTT DM1M67Q MA Inhibitor DM1M67Q RN beta-Keto sulfones as inhibitors of 11beta-hydroxysteroid dehydrogenase type I and the mechanism of action. Bioorg Med Chem. 2007 Jul 1;15(13):4396-405. DM1M67Q RU https://pubmed.ncbi.nlm.nih.gov/17490884 DMOC67J DI DMOC67J DMOC67J DN 1-(4-Nitro-phenyl)-2-phenyl-ethane-1,2-dione DMOC67J MI TTMF541 DMOC67J MN Liver carboxylesterase (CES1) DMOC67J MT DTT DMOC67J MA Inhibitor DMOC67J RN Identification and characterization of novel benzil (diphenylethane-1,2-dione) analogues as inhibitors of mammalian carboxylesterases. J Med Chem. 2005 Apr 21;48(8):2906-15. DMOC67J RU https://pubmed.ncbi.nlm.nih.gov/15828829 DME435S DI DME435S DME435S DN 1-(4-nitrophenyl)-2-pyrrolidin-1-yl-pentan-1-one DME435S MI TTVBI8W DME435S MN Dopamine transporter (DAT) DME435S MT DTT DME435S MA Inhibitor DME435S RN 1-(4-Methylphenyl)-2-pyrrolidin-1-yl-pentan-1-one (Pyrovalerone) analogues: a promising class of monoamine uptake inhibitors. J Med Chem. 2006 Feb 23;49(4):1420-32. DME435S RU https://pubmed.ncbi.nlm.nih.gov/16480278 DME435S DI DME435S DME435S DN 1-(4-nitrophenyl)-2-pyrrolidin-1-yl-pentan-1-one DME435S MI TTAWNKZ DME435S MN Norepinephrine transporter (NET) DME435S MT DTT DME435S MA Inhibitor DME435S RN 1-(4-Methylphenyl)-2-pyrrolidin-1-yl-pentan-1-one (Pyrovalerone) analogues: a promising class of monoamine uptake inhibitors. J Med Chem. 2006 Feb 23;49(4):1420-32. DME435S RU https://pubmed.ncbi.nlm.nih.gov/16480278 DME435S DI DME435S DME435S DN 1-(4-nitrophenyl)-2-pyrrolidin-1-yl-pentan-1-one DME435S MI TT3ROYC DME435S MN Serotonin transporter (SERT) DME435S MT DTT DME435S MA Inhibitor DME435S RN 1-(4-Methylphenyl)-2-pyrrolidin-1-yl-pentan-1-one (Pyrovalerone) analogues: a promising class of monoamine uptake inhibitors. J Med Chem. 2006 Feb 23;49(4):1420-32. DME435S RU https://pubmed.ncbi.nlm.nih.gov/16480278 DMQKMCG DI DMQKMCG DMQKMCG DN 1-(4-nonylbenzyl)azetidine-3-carboxylic acid DMQKMCG MI TT9JZCK DMQKMCG MN Sphingosine-1-phosphate receptor 1 (S1PR1) DMQKMCG MT DTT DMQKMCG MA Inhibitor DMQKMCG RN A rational utilization of high-throughput screening affords selective, orally bioavailable 1-benzyl-3-carboxyazetidine sphingosine-1-phosphate-1 re... J Med Chem. 2004 Dec 30;47(27):6662-5. DMQKMCG RU https://pubmed.ncbi.nlm.nih.gov/15615513 DM8U2HP DI DM8U2HP DM8U2HP DN 1-(4-nonylbenzyl)pyrrolidin-3-ylphosphonic acid DM8U2HP MI TT9JZCK DM8U2HP MN Sphingosine-1-phosphate receptor 1 (S1PR1) DM8U2HP MT DTT DM8U2HP MA Inhibitor DM8U2HP RN A rational utilization of high-throughput screening affords selective, orally bioavailable 1-benzyl-3-carboxyazetidine sphingosine-1-phosphate-1 re... J Med Chem. 2004 Dec 30;47(27):6662-5. DM8U2HP RU https://pubmed.ncbi.nlm.nih.gov/15615513 DMAR39L DI DMAR39L DMAR39L DN 1-(4-nonylbenzyl)pyrrolidine-3-carboxylic acid DMAR39L MI TT9JZCK DMAR39L MN Sphingosine-1-phosphate receptor 1 (S1PR1) DMAR39L MT DTT DMAR39L MA Inhibitor DMAR39L RN A rational utilization of high-throughput screening affords selective, orally bioavailable 1-benzyl-3-carboxyazetidine sphingosine-1-phosphate-1 re... J Med Chem. 2004 Dec 30;47(27):6662-5. DMAR39L RU https://pubmed.ncbi.nlm.nih.gov/15615513 DM9KVBJ DI DM9KVBJ DM9KVBJ DN 1-(4-octylphenyl)prop-2-en-1-one DM9KVBJ MI TTGER3L DM9KVBJ MN Thyroid hormone receptor beta (THRB) DM9KVBJ MT DTT DM9KVBJ MA Inhibitor DM9KVBJ RN Inhibitors of the interaction of a thyroid hormone receptor and coactivators: preliminary structure-activity relationships. J Med Chem. 2007 Nov 1;50(22):5269-80. DM9KVBJ RU https://pubmed.ncbi.nlm.nih.gov/17918822 DMVCM0I DI DMVCM0I DMVCM0I DN 1-(4-Phenoxyphenyl)piperazine DMVCM0I MI TTXZEAJ DMVCM0I MN Leukotriene A-4 hydrolase (LTA4H) DMVCM0I MT DTT DMVCM0I MA Inhibitor DMVCM0I RN Discovery of 4-[(2S)-2-{[4-(4-chlorophenoxy)phenoxy]methyl}-1-pyrrolidinyl]butanoic acid (DG-051) as a novel leukotriene A4 hydrolase inhibitor of ... J Med Chem. 2010 Jan 28;53(2):573-85. DMVCM0I RU https://pubmed.ncbi.nlm.nih.gov/19950900 DMKNA5U DI DMKNA5U DMKNA5U DN 1-(4-propoxyphenyl)propan-2-amine DMKNA5U MI TT3WG5C DMKNA5U MN Monoamine oxidase type A (MAO-A) DMKNA5U MT DTT DMKNA5U MA Inhibitor DMKNA5U RN Naphthylisopropylamine and N-benzylamphetamine derivatives as monoamine oxidase inhibitors. Bioorg Med Chem. 2009 Mar 15;17(6):2452-60. DMKNA5U RU https://pubmed.ncbi.nlm.nih.gov/19243954 DMFYK6T DI DMFYK6T DMFYK6T DN 1-(4-p-Tolyl-butyl)-piperidine DMFYK6T MI TTTIBOJ DMFYK6T MN Histamine H1 receptor (H1R) DMFYK6T MT DTT DMFYK6T MA Inhibitor DMFYK6T RN Structural determinants for histamine H(1) affinity, hERG affinity and QTc prolongation in a series of terfenadine analogs. Bioorg Med Chem Lett. 2009 Sep 1;19(17):5043-7. DMFYK6T RU https://pubmed.ncbi.nlm.nih.gov/19660947 DMFYK6T DI DMFYK6T DMFYK6T DN 1-(4-p-Tolyl-butyl)-piperidine DMFYK6T MI TTQ6VDM DMFYK6T MN Voltage-gated potassium channel Kv11.1 (KCNH2) DMFYK6T MT DTT DMFYK6T MA Inhibitor DMFYK6T RN Structural determinants for histamine H(1) affinity, hERG affinity and QTc prolongation in a series of terfenadine analogs. Bioorg Med Chem Lett. 2009 Sep 1;19(17):5043-7. DMFYK6T RU https://pubmed.ncbi.nlm.nih.gov/19660947 DMM7IJZ DI DMM7IJZ DMM7IJZ DN 1-(4-tert-butylphenylsulfonyl)-4-methoxyazepane DMM7IJZ MI TTN7BL9 DMM7IJZ MN Corticosteroid 11-beta-dehydrogenase 1 (HSD11B1) DMM7IJZ MT DTT DMM7IJZ MA Inhibitor DMM7IJZ RN The discovery of azepane sulfonamides as potent 11beta-HSD1 inhibitors. Bioorg Med Chem Lett. 2009 Aug 15;19(16):4563-5. DMM7IJZ RU https://pubmed.ncbi.nlm.nih.gov/19625185 DMQECWT DI DMQECWT DMQECWT DN 1-(4-tert-butylphenylsulfonyl)azepan-4-ol DMQECWT MI TTN7BL9 DMQECWT MN Corticosteroid 11-beta-dehydrogenase 1 (HSD11B1) DMQECWT MT DTT DMQECWT MA Inhibitor DMQECWT RN The discovery of azepane sulfonamides as potent 11beta-HSD1 inhibitors. Bioorg Med Chem Lett. 2009 Aug 15;19(16):4563-5. DMQECWT RU https://pubmed.ncbi.nlm.nih.gov/19625185 DMPL3UZ DI DMPL3UZ DMPL3UZ DN 1-(5-(furan-2-yl)oxazol-2-yl)octadec-9-en-1-one DMPL3UZ MI TTDP1UC DMPL3UZ MN Fatty acid amide hydrolase (FAAH) DMPL3UZ MT DTT DMPL3UZ MA Inhibitor DMPL3UZ RN Optimization of the central heterocycle of alpha-ketoheterocycle inhibitors of fatty acid amide hydrolase. J Med Chem. 2008 Aug 14;51(15):4392-403. DMPL3UZ RU https://pubmed.ncbi.nlm.nih.gov/18630870 DM4V9IB DI DM4V9IB DM4V9IB DN 1-(5-(pyridin-2-yl)oxazol-2-yl)dodecan-1-one DM4V9IB MI TTDP1UC DM4V9IB MN Fatty acid amide hydrolase (FAAH) DM4V9IB MT DTT DM4V9IB MA Inhibitor DM4V9IB RN Inhibitors of proteases and amide hydrolases that employ an alpha-ketoheterocycle as a key enabling functionality. Bioorg Med Chem. 2008 Feb 15;16(4):1562-95. DM4V9IB RU https://pubmed.ncbi.nlm.nih.gov/18053726 DMICZK0 DI DMICZK0 DMICZK0 DN 1-(5-(pyridin-2-yl)oxazol-2-yl)octadec-9-en-1-one DMICZK0 MI TTDP1UC DMICZK0 MN Fatty acid amide hydrolase (FAAH) DMICZK0 MT DTT DMICZK0 MA Inhibitor DMICZK0 RN Optimization of the central heterocycle of alpha-ketoheterocycle inhibitors of fatty acid amide hydrolase. J Med Chem. 2008 Aug 14;51(15):4392-403. DMICZK0 RU https://pubmed.ncbi.nlm.nih.gov/18630870 DMZNEIB DI DMZNEIB DMZNEIB DN 1-(5-(pyridin-2-yl)oxazol-2-yl)octan-1-one DMZNEIB MI TTDP1UC DMZNEIB MN Fatty acid amide hydrolase (FAAH) DMZNEIB MT DTT DMZNEIB MA Inhibitor DMZNEIB RN Inhibitors of proteases and amide hydrolases that employ an alpha-ketoheterocycle as a key enabling functionality. Bioorg Med Chem. 2008 Feb 15;16(4):1562-95. DMZNEIB RU https://pubmed.ncbi.nlm.nih.gov/18053726 DM6FDAY DI DM6FDAY DM6FDAY DN 1-(5-(pyridin-2-yl)oxazol-2-yl)pentan-1-one DM6FDAY MI TTDP1UC DM6FDAY MN Fatty acid amide hydrolase (FAAH) DM6FDAY MT DTT DM6FDAY MA Inhibitor DM6FDAY RN Inhibitors of proteases and amide hydrolases that employ an alpha-ketoheterocycle as a key enabling functionality. Bioorg Med Chem. 2008 Feb 15;16(4):1562-95. DM6FDAY RU https://pubmed.ncbi.nlm.nih.gov/18053726 DMDTYAF DI DMDTYAF DMDTYAF DN 1-(5-chloro-2-hydroxy-4-nitrophenyl)-3-phenylurea DMDTYAF MI TT30C9G DMDTYAF MN C-X-C chemokine receptor type 2 (CXCR2) DMDTYAF MT DTT DMDTYAF MA Inhibitor DMDTYAF RN Comparison of N,N'-diarylsquaramides and N,N'-diarylureas as antagonists of the CXCR2 chemokine receptor. Bioorg Med Chem Lett. 2007 Mar 15;17(6):1713-7. DMDTYAF RU https://pubmed.ncbi.nlm.nih.gov/17236763 DMD8IYZ DI DMD8IYZ DMD8IYZ DN 1-(5-fluorooxazol-2-yl)-7-phenylheptan-1-one DMD8IYZ MI TTDP1UC DMD8IYZ MN Fatty acid amide hydrolase (FAAH) DMD8IYZ MT DTT DMD8IYZ MA Inhibitor DMD8IYZ RN Inhibitors of proteases and amide hydrolases that employ an alpha-ketoheterocycle as a key enabling functionality. Bioorg Med Chem. 2008 Feb 15;16(4):1562-95. DMD8IYZ RU https://pubmed.ncbi.nlm.nih.gov/18053726 DMWQ9ZP DI DMWQ9ZP DMWQ9ZP DN 1-(5-methyloxazol-2-yl)-7-phenylheptan-1-one DMWQ9ZP MI TTDP1UC DMWQ9ZP MN Fatty acid amide hydrolase (FAAH) DMWQ9ZP MT DTT DMWQ9ZP MA Inhibitor DMWQ9ZP RN Inhibitors of proteases and amide hydrolases that employ an alpha-ketoheterocycle as a key enabling functionality. Bioorg Med Chem. 2008 Feb 15;16(4):1562-95. DMWQ9ZP RU https://pubmed.ncbi.nlm.nih.gov/18053726 DMRITHA DI DMRITHA DMRITHA DN 1-(5-phenyloxazol-2-yl)octadec-9-en-1-one DMRITHA MI TTDP1UC DMRITHA MN Fatty acid amide hydrolase (FAAH) DMRITHA MT DTT DMRITHA MA Inhibitor DMRITHA RN Optimization of the central heterocycle of alpha-ketoheterocycle inhibitors of fatty acid amide hydrolase. J Med Chem. 2008 Aug 14;51(15):4392-403. DMRITHA RU https://pubmed.ncbi.nlm.nih.gov/18630870 DM4IMON DI DM4IMON DM4IMON DN 1-(5-Pyridin-2-yl-oxazol-2-yl)-octadec-9-yn-1-one DM4IMON MI TTDP1UC DM4IMON MN Fatty acid amide hydrolase (FAAH) DM4IMON MT DTT DM4IMON MA Inhibitor DM4IMON RN Discovery of a potent, selective, and efficacious class of reversible alpha-ketoheterocycle inhibitors of fatty acid amide hydrolase effective as a... J Med Chem. 2005 Mar 24;48(6):1849-56. DM4IMON RU https://pubmed.ncbi.nlm.nih.gov/15771430 DMUS9Z3 DI DMUS9Z3 DMUS9Z3 DN 1-(6-Amino-4-methylpyridin-2-yl)propan-2-ol DMUS9Z3 MI TTF10I9 DMUS9Z3 MN Nitric-oxide synthase inducible (NOS2) DMUS9Z3 MT DTT DMUS9Z3 MA Inhibitor DMUS9Z3 RN Design and synthesis of 2-amino-4-methylpyridine analogues as inhibitors for inducible nitric oxide synthase and in vivo evaluation of [18F]6-(2-fl... J Med Chem. 2009 Apr 23;52(8):2443-53. DMUS9Z3 RU https://pubmed.ncbi.nlm.nih.gov/19323559 DMEHK4F DI DMEHK4F DMEHK4F DN 1-(6-Methoxy-naphthalen-2-yl)-1H-imidazole DMEHK4F MI TTIQUX7 DMEHK4F MN Steroid 11-beta-hydroxylase (CYP11B1) DMEHK4F MT DTT DMEHK4F MA Inhibitor DMEHK4F RN Heteroaryl-substituted naphthalenes and structurally modified derivatives: selective inhibitors of CYP11B2 for the treatment of congestive heart fa... J Med Chem. 2005 Oct 20;48(21):6632-42. DMEHK4F RU https://pubmed.ncbi.nlm.nih.gov/16220979 DM7OGLI DI DM7OGLI DM7OGLI DN 1-(7-Hydroxy-naphthalen-1-yl)-3-pyridin-2-yl-urea DM7OGLI MI TT0PG8F DM7OGLI MN Cyclin-dependent kinase 4 (CDK4) DM7OGLI MT DTT DM7OGLI MA Inhibitor DM7OGLI RN Structure-based generation of a new class of potent Cdk4 inhibitors: new de novo design strategy and library design. J Med Chem. 2001 Dec 20;44(26):4615-27. DM7OGLI RU https://pubmed.ncbi.nlm.nih.gov/11741479 DMLHDE3 DI DMLHDE3 DMLHDE3 DN 1-(7-Methoxy-2-phenyl-chroman-4-yl)-1H-imidazole DMLHDE3 MI TTSZLWK DMLHDE3 MN Aromatase (CYP19A1) DMLHDE3 MT DTT DMLHDE3 MA Inhibitor DMLHDE3 RN Synthesis and evaluation of 4-triazolylflavans as new aromatase inhibitors. Bioorg Med Chem Lett. 2004 Oct 18;14(20):5215-8. DMLHDE3 RU https://pubmed.ncbi.nlm.nih.gov/15380230 DM1MJCE DI DM1MJCE DM1MJCE DN 1-(7-Methoxy-naphthalen-2-yl)-piperazine DM1MJCE MI TTSQIFT DM1MJCE MN 5-HT 1A receptor (HTR1A) DM1MJCE MT DTT DM1MJCE MA Inhibitor DM1MJCE RN 5-HT1B receptor antagonist properties of novel arylpiperazide derivatives of 1-naphthylpiperazine. J Med Chem. 1997 Nov 21;40(24):3974-8. DM1MJCE RU https://pubmed.ncbi.nlm.nih.gov/9397179 DM1MJCE DI DM1MJCE DM1MJCE DN 1-(7-Methoxy-naphthalen-2-yl)-piperazine DM1MJCE MI TTK8CXU DM1MJCE MN 5-HT 1B receptor (HTR1B) DM1MJCE MT DTT DM1MJCE MA Inhibitor DM1MJCE RN 5-HT1B receptor antagonist properties of novel arylpiperazide derivatives of 1-naphthylpiperazine. J Med Chem. 1997 Nov 21;40(24):3974-8. DM1MJCE RU https://pubmed.ncbi.nlm.nih.gov/9397179 DM1MJCE DI DM1MJCE DM1MJCE DN 1-(7-Methoxy-naphthalen-2-yl)-piperazine DM1MJCE MI TT6MSOK DM1MJCE MN 5-HT 1D receptor (HTR1D) DM1MJCE MT DTT DM1MJCE MA Inhibitor DM1MJCE RN 5-HT1B receptor antagonist properties of novel arylpiperazide derivatives of 1-naphthylpiperazine. J Med Chem. 1997 Nov 21;40(24):3974-8. DM1MJCE RU https://pubmed.ncbi.nlm.nih.gov/9397179 DMKHJBI DI DMKHJBI DMKHJBI DN 1-(7-methyl-9H-carbazol-3-yl)ethanone DMKHJBI MI TTBGTCW DMKHJBI MN Kinesin spindle messenger RNA (KIF11 mRNA) DMKHJBI MT DTT DMKHJBI MA Inhibitor DMKHJBI RN Kinesin spindle protein (KSP) inhibitors with 2,3-fused indole scaffolds. J Med Chem. 2010 Jul 8;53(13):5054-8. DMKHJBI RU https://pubmed.ncbi.nlm.nih.gov/20521839 DMC3PYM DI DMC3PYM DMC3PYM DN 1-(9-ethyl-9H-carbazol-3-yl)-N-methylmethanamine DMC3PYM MI TT7SBF5 DMC3PYM MN Cellular tumor antigen p53 (TP53) DMC3PYM MT DTT DMC3PYM MA Inhibitor DMC3PYM RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DMC3PYM RU https://pubmed.ncbi.nlm.nih.gov/10592235 DMA96U5 DI DMA96U5 DMA96U5 DN 1-(9H-beta-Carbolin-3-yl)-butan-1-one DMA96U5 MI TT1MPAY DMA96U5 MN GABA(A) receptor alpha-1 (GABRA1) DMA96U5 MT DTT DMA96U5 MA Inhibitor DMA96U5 RN Predictive binding of beta-carboline inverse agonists and antagonists via the CoMFA/GOLPE approach. J Med Chem. 1992 Oct 30;35(22):4001-10. DMA96U5 RU https://pubmed.ncbi.nlm.nih.gov/1331452 DMA96U5 DI DMA96U5 DMA96U5 DN 1-(9H-beta-Carbolin-3-yl)-butan-1-one DMA96U5 MI TTNJYV2 DMA96U5 MN Gamma-aminobutyric acid receptor (GAR) DMA96U5 MT DTT DMA96U5 MA Inhibitor DMA96U5 RN Predictive binding of beta-carboline inverse agonists and antagonists via the CoMFA/GOLPE approach. J Med Chem. 1992 Oct 30;35(22):4001-10. DMA96U5 RU https://pubmed.ncbi.nlm.nih.gov/1331452 DMFOD2L DI DMFOD2L DMFOD2L DN 1-(9H-beta-Carbolin-3-yl)-ethanone DMFOD2L MI TT1MPAY DMFOD2L MN GABA(A) receptor alpha-1 (GABRA1) DMFOD2L MT DTT DMFOD2L MA Inhibitor DMFOD2L RN Synthesis of 6-substituted beta-carbolines that behave as benzodiazepine receptor antagonists or inverse agonists. J Med Chem. 1987 Apr;30(4):750-3. DMFOD2L RU https://pubmed.ncbi.nlm.nih.gov/3031296 DMFOD2L DI DMFOD2L DMFOD2L DN 1-(9H-beta-Carbolin-3-yl)-ethanone DMFOD2L MI TTNJYV2 DMFOD2L MN Gamma-aminobutyric acid receptor (GAR) DMFOD2L MT DTT DMFOD2L MA Inhibitor DMFOD2L RN Synthesis of 6-substituted beta-carbolines that behave as benzodiazepine receptor antagonists or inverse agonists. J Med Chem. 1987 Apr;30(4):750-3. DMFOD2L RU https://pubmed.ncbi.nlm.nih.gov/3031296 DMH49OD DI DMH49OD DMH49OD DN 1-(9H-fluoren-9-yl)-1H-imidazole DMH49OD MI TTSZLWK DMH49OD MN Aromatase (CYP19A1) DMH49OD MT DTT DMH49OD MA Inhibitor DMH49OD RN Fast three dimensional pharmacophore virtual screening of new potent non-steroid aromatase inhibitors. J Med Chem. 2009 Jan 8;52(1):143-50. DMH49OD RU https://pubmed.ncbi.nlm.nih.gov/19072235 DM30FNL DI DM30FNL DM30FNL DN 1-(9-Oxo-9H-fluoren-4-yl)-3-pyridin-2-yl-urea DM30FNL MI TT0PG8F DM30FNL MN Cyclin-dependent kinase 4 (CDK4) DM30FNL MT DTT DM30FNL MA Inhibitor DM30FNL RN Structure-based generation of a new class of potent Cdk4 inhibitors: new de novo design strategy and library design. J Med Chem. 2001 Dec 20;44(26):4615-27. DM30FNL RU https://pubmed.ncbi.nlm.nih.gov/11741479 DMVJZ0C DI DMVJZ0C DMVJZ0C DN 1-(9-phenyl-9H-fluoren-9-yl)-1H-1,2,4-triazole DMVJZ0C MI TTSZLWK DMVJZ0C MN Aromatase (CYP19A1) DMVJZ0C MT DTT DMVJZ0C MA Inhibitor DMVJZ0C RN Fast three dimensional pharmacophore virtual screening of new potent non-steroid aromatase inhibitors. J Med Chem. 2009 Jan 8;52(1):143-50. DMVJZ0C RU https://pubmed.ncbi.nlm.nih.gov/19072235 DMLIJYS DI DMLIJYS DMLIJYS DN 1-(9-Phenyl-9H-fluoren-9-yl)1H-imidazole DMLIJYS MI TTSZLWK DMLIJYS MN Aromatase (CYP19A1) DMLIJYS MT DTT DMLIJYS MA Inhibitor DMLIJYS RN Pharmacophore modeling strategies for the development of novel nonsteroidal inhibitors of human aromatase (CYP19). Bioorg Med Chem Lett. 2010 May 15;20(10):3050-64. DMLIJYS RU https://pubmed.ncbi.nlm.nih.gov/20413308 DMOTJWZ DI DMOTJWZ DMOTJWZ DN 1-(adamantan-1-yl)-2-(1H-imidazol-1-yl)ethanone DMOTJWZ MI TTI6V2A DMOTJWZ MN Heme oxygenase 1 (HMOX1) DMOTJWZ MT DTT DMOTJWZ MA Inhibitor DMOTJWZ RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DMOTJWZ RU https://pubmed.ncbi.nlm.nih.gov/10592235 DMOJC9Z DI DMOJC9Z DMOJC9Z DN 1-(Benzhydrylamino)ethaniminium bromide DMOJC9Z MI TTZUFI5 DMOJC9Z MN Nitric-oxide synthase brain (NOS1) DMOJC9Z MT DTT DMOJC9Z MA Inhibitor DMOJC9Z RN N-Substituted acetamidines and 2-methylimidazole derivatives as selective inhibitors of neuronal nitric oxide synthase. Bioorg Med Chem Lett. 2010 Nov 15;20(22):6495-9. DMOJC9Z RU https://pubmed.ncbi.nlm.nih.gov/20933416 DMGNL2A DI DMGNL2A DMGNL2A DN 1-(benzofuran-2-yl)-3-aza-bicyclo[3.1.0]hexane DMGNL2A MI TTVBI8W DMGNL2A MN Dopamine transporter (DAT) DMGNL2A MT DTT DMGNL2A MA Inhibitor DMGNL2A RN Studies on the structure-activity relationship of bicifadine analogs as monoamine transporter inhibitors. Bioorg Med Chem Lett. 2008 Jul 1;18(13):3682-6. DMGNL2A RU https://pubmed.ncbi.nlm.nih.gov/18539031 DMGNL2A DI DMGNL2A DMGNL2A DN 1-(benzofuran-2-yl)-3-aza-bicyclo[3.1.0]hexane DMGNL2A MI TT3ROYC DMGNL2A MN Serotonin transporter (SERT) DMGNL2A MT DTT DMGNL2A MA Inhibitor DMGNL2A RN Studies on the structure-activity relationship of bicifadine analogs as monoamine transporter inhibitors. Bioorg Med Chem Lett. 2008 Jul 1;18(13):3682-6. DMGNL2A RU https://pubmed.ncbi.nlm.nih.gov/18539031 DMVSC3O DI DMVSC3O DMVSC3O DN 1-(benzyloxy)-2-(2-phenylethyl)benzene DMVSC3O MI TTSQIFT DMVSC3O MN 5-HT 1A receptor (HTR1A) DMVSC3O MT DTT DMVSC3O MA Inhibitor DMVSC3O RN Arylmethyloxyphenyl derivatives: small molecules displaying P-glycoprotein inhibition. J Med Chem. 2006 Nov 2;49(22):6607-13. DMVSC3O RU https://pubmed.ncbi.nlm.nih.gov/17064079 DMVSC3O DI DMVSC3O DMVSC3O DN 1-(benzyloxy)-2-(2-phenylethyl)benzene DMVSC3O MI TTEX248 DMVSC3O MN Dopamine D2 receptor (D2R) DMVSC3O MT DTT DMVSC3O MA Inhibitor DMVSC3O RN Arylmethyloxyphenyl derivatives: small molecules displaying P-glycoprotein inhibition. J Med Chem. 2006 Nov 2;49(22):6607-13. DMVSC3O RU https://pubmed.ncbi.nlm.nih.gov/17064079 DMVB7P3 DI DMVB7P3 DMVB7P3 DN 1-(benzyloxy)-2-[2-(3-methoxyphenyl)ethyl]benzene DMVB7P3 MI TTSQIFT DMVB7P3 MN 5-HT 1A receptor (HTR1A) DMVB7P3 MT DTT DMVB7P3 MA Inhibitor DMVB7P3 RN Arylmethyloxyphenyl derivatives: small molecules displaying P-glycoprotein inhibition. J Med Chem. 2006 Nov 2;49(22):6607-13. DMVB7P3 RU https://pubmed.ncbi.nlm.nih.gov/17064079 DMVB7P3 DI DMVB7P3 DMVB7P3 DN 1-(benzyloxy)-2-[2-(3-methoxyphenyl)ethyl]benzene DMVB7P3 MI TTEX248 DMVB7P3 MN Dopamine D2 receptor (D2R) DMVB7P3 MT DTT DMVB7P3 MA Inhibitor DMVB7P3 RN Arylmethyloxyphenyl derivatives: small molecules displaying P-glycoprotein inhibition. J Med Chem. 2006 Nov 2;49(22):6607-13. DMVB7P3 RU https://pubmed.ncbi.nlm.nih.gov/17064079 DMA15X9 DI DMA15X9 DMA15X9 DN 1(beta)-O-galloylpedunculagin DMA15X9 MI TTE14XG DMA15X9 MN Squalene monooxygenase (SQLE) DMA15X9 MT DTT DMA15X9 MA Inhibitor DMA15X9 RN Ellagitannins and hexahydroxydiphenoyl esters as inhibitors of vertebrate squalene epoxidase. J Nat Prod. 2001 Aug;64(8):1010-4. DMA15X9 RU https://pubmed.ncbi.nlm.nih.gov/11520216 DMGVPMT DI DMGVPMT DMGVPMT DN 1-(biphenyl-3-ylmethyl)-1H-1,2,4-triazole DMGVPMT MI TTSZLWK DMGVPMT MN Aromatase (CYP19A1) DMGVPMT MT DTT DMGVPMT MA Inhibitor DMGVPMT RN Highly potent first examples of dual aromatase-steroid sulfatase inhibitors based on a biphenyl template. J Med Chem. 2010 Mar 11;53(5):2155-70. DMGVPMT RU https://pubmed.ncbi.nlm.nih.gov/20148564 DM5KZ74 DI DM5KZ74 DM5KZ74 DN 1-(biphenyl-4-yl)-3-(4-(piperidin-1-yl)butyl)urea DM5KZ74 MI TTPC4TU DM5KZ74 MN 5-HT 3A receptor (HTR3A) DM5KZ74 MT DTT DM5KZ74 MA Inhibitor DM5KZ74 RN Novel alpha-7 nicotinic acetylcholine receptor agonists containing a urea moiety: identification and characterization of the potent, selective, and... J Med Chem. 2010 Jun 10;53(11):4379-89. DM5KZ74 RU https://pubmed.ncbi.nlm.nih.gov/20465311 DMTZ71K DI DMTZ71K DMTZ71K DN 1-(bis(3-bromophenyl)methylene)thiosemicarbazide DMTZ71K MI TTEAID7 DMTZ71K MN Trypanosoma Cruzipain (Trypano CYSP) DMTZ71K MT DTT DMTZ71K MA Inhibitor DMTZ71K RN Design, synthesis, and biochemical evaluation of novel cruzain inhibitors with potential application in the treatment of Chagas' disease. Bioorg Med Chem Lett. 2006 Aug 15;16(16):4405-9. DMTZ71K RU https://pubmed.ncbi.nlm.nih.gov/16781147 DMYO8D3 DI DMYO8D3 DMYO8D3 DN 1-(bis(4-bromophenyl)methyl)-3-phenylurea DMYO8D3 MI TT6OEDT DMYO8D3 MN Cannabinoid receptor 1 (CB1) DMYO8D3 MT DTT DMYO8D3 MA Inhibitor DMYO8D3 RN 1-Benzhydryl-3-phenylurea and 1-benzhydryl-3-phenylthiourea derivatives: new templates among the CB1 cannabinoid receptor inverse agonists. J Med Chem. 2005 Nov 17;48(23):7486-90. DMYO8D3 RU https://pubmed.ncbi.nlm.nih.gov/16279809 DMTVNO3 DI DMTVNO3 DMTVNO3 DN 1-(bis(4-chlorophenyl)methyl)-3-phenylurea DMTVNO3 MI TT6OEDT DMTVNO3 MN Cannabinoid receptor 1 (CB1) DMTVNO3 MT DTT DMTVNO3 MA Inhibitor DMTVNO3 RN 1-Benzhydryl-3-phenylurea and 1-benzhydryl-3-phenylthiourea derivatives: new templates among the CB1 cannabinoid receptor inverse agonists. J Med Chem. 2005 Nov 17;48(23):7486-90. DMTVNO3 RU https://pubmed.ncbi.nlm.nih.gov/16279809 DMF3D5R DI DMF3D5R DMF3D5R DN 1-(Bis-biphenyl-4-yl-methyl)-1H-imidazole DMF3D5R MI TTRA5BZ DMF3D5R MN Steroid 17-alpha-monooxygenase (S17AH) DMF3D5R MT DTT DMF3D5R MA Inhibitor DMF3D5R RN Synthesis, biological evaluation, and molecular modeling studies of methylene imidazole substituted biaryls as inhibitors of human 17alpha-hydroxyl... Bioorg Med Chem. 2008 Aug 15;16(16):7715-27. DMF3D5R RU https://pubmed.ncbi.nlm.nih.gov/18674917 DMEULBF DI DMEULBF DMEULBF DN 1-(But-2-enylidene)thiosemicarbazide DMEULBF MI TTULVH8 DMEULBF MN Tyrosinase (TYR) DMEULBF MT DTT DMEULBF MA Inhibitor DMEULBF RN A class of potent tyrosinase inhibitors: alkylidenethiosemicarbazide compounds. Eur J Med Chem. 2009 Apr;44(4):1773-8. DMEULBF RU https://pubmed.ncbi.nlm.nih.gov/18524420 DMTMZAJ DI DMTMZAJ DMTMZAJ DN 1-(but-2-ylamino)ethyl 1,I-bisphosphonic acid DMTMZAJ MI TTIKWV4 DMTMZAJ MN Geranyltranstransferase (FDPS) DMTMZAJ MT DTT DMTMZAJ MA Inhibitor DMTMZAJ RN Synthesis and biological evaluation of 2-alkylaminoethyl-1,1-bisphosphonic acids against Trypanosoma cruzi and Toxoplasma gondii targeting farnesyl... Bioorg Med Chem. 2008 Mar 15;16(6):3283-90. DMTMZAJ RU https://pubmed.ncbi.nlm.nih.gov/18096393 DMXU1EF DI DMXU1EF DMXU1EF DN 1-(Butan-2-ylidene)thiosemicarbazide DMXU1EF MI TTULVH8 DMXU1EF MN Tyrosinase (TYR) DMXU1EF MT DTT DMXU1EF MA Inhibitor DMXU1EF RN A class of potent tyrosinase inhibitors: alkylidenethiosemicarbazide compounds. Eur J Med Chem. 2009 Apr;44(4):1773-8. DMXU1EF RU https://pubmed.ncbi.nlm.nih.gov/18524420 DMS3XUC DI DMS3XUC DMS3XUC DN 1-(cyclohexyl)methyl-5'-O-tritylinosine DMS3XUC MI TTO0IB8 DMS3XUC MN Thymidine phosphorylase (TYMP) DMS3XUC MT DTT DMS3XUC MA Inhibitor DMS3XUC RN 5'-O-tritylinosine and analogues as allosteric inhibitors of human thymidine phosphorylase. J Med Chem. 2006 Sep 7;49(18):5562-70. DMS3XUC RU https://pubmed.ncbi.nlm.nih.gov/16942029 DMDU3X7 DI DMDU3X7 DMDU3X7 DN 1-(cyclopropyl)methyl-5'-O-tritylinosine DMDU3X7 MI TTO0IB8 DMDU3X7 MN Thymidine phosphorylase (TYMP) DMDU3X7 MT DTT DMDU3X7 MA Inhibitor DMDU3X7 RN 5'-O-tritylinosine and analogues as allosteric inhibitors of human thymidine phosphorylase. J Med Chem. 2006 Sep 7;49(18):5562-70. DMDU3X7 RU https://pubmed.ncbi.nlm.nih.gov/16942029 DMLYO8P DI DMLYO8P DMLYO8P DN 1-(dio-tolylmethyl)-4-phenylpiperidin-4-ol DMLYO8P MI TTNT7K8 DMLYO8P MN Nociceptin receptor (OPRL1) DMLYO8P MT DTT DMLYO8P MA Inhibitor DMLYO8P RN Bioorg Med Chem Lett. 2007 Jun 1;17(11):3023-7. Epub 2007 Mar 23.Synthesis and structure-activity relationships of 4-hydroxy-4-phenylpiperidines as nociceptin receptor ligands: Part 1. DMLYO8P RU https://pubmed.ncbi.nlm.nih.gov/17428659 DMLYO8P DI DMLYO8P DMLYO8P DN 1-(dio-tolylmethyl)-4-phenylpiperidin-4-ol DMLYO8P MI TT27RFC DMLYO8P MN Opioid receptor delta (OPRD1) DMLYO8P MT DTT DMLYO8P MA Inhibitor DMLYO8P RN Bioorg Med Chem Lett. 2007 Jun 1;17(11):3023-7. Epub 2007 Mar 23.Synthesis and structure-activity relationships of 4-hydroxy-4-phenylpiperidines as nociceptin receptor ligands: Part 1. DMLYO8P RU https://pubmed.ncbi.nlm.nih.gov/17428659 DMLYO8P DI DMLYO8P DMLYO8P DN 1-(dio-tolylmethyl)-4-phenylpiperidin-4-ol DMLYO8P MI TTQW87Y DMLYO8P MN Opioid receptor kappa (OPRK1) DMLYO8P MT DTT DMLYO8P MA Inhibitor DMLYO8P RN Bioorg Med Chem Lett. 2007 Jun 1;17(11):3023-7. Epub 2007 Mar 23.Synthesis and structure-activity relationships of 4-hydroxy-4-phenylpiperidines as nociceptin receptor ligands: Part 1. DMLYO8P RU https://pubmed.ncbi.nlm.nih.gov/17428659 DMLYO8P DI DMLYO8P DMLYO8P DN 1-(dio-tolylmethyl)-4-phenylpiperidin-4-ol DMLYO8P MI TTKWM86 DMLYO8P MN Opioid receptor mu (MOP) DMLYO8P MT DTT DMLYO8P MA Inhibitor DMLYO8P RN Bioorg Med Chem Lett. 2007 Jun 1;17(11):3023-7. Epub 2007 Mar 23.Synthesis and structure-activity relationships of 4-hydroxy-4-phenylpiperidines as nociceptin receptor ligands: Part 1. DMLYO8P RU https://pubmed.ncbi.nlm.nih.gov/17428659 DMBTLIJ DI DMBTLIJ DMBTLIJ DN 1-(HYDROXYMETHYLENEAMINO)-8-HYDROXY-OCTANE DMBTLIJ MI TT6L509 DMBTLIJ MN Coagulation factor IIa (F2) DMBTLIJ MT DTT DMBTLIJ MA Inhibitor DMBTLIJ RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DMBTLIJ RU https://pubmed.ncbi.nlm.nih.gov/10592235 DMOTICP DI DMOTICP DMOTICP DN 1-(isoquinolin-5-yl)-3-(1-phenylpropyl)urea DMOTICP MI TTMI6F5 DMOTICP MN Transient receptor potential cation channel V1 (TRPV1) DMOTICP MT DTT DMOTICP MA Inhibitor DMOTICP RN Alpha-methylation at benzylic fragment of N-aryl-N'-benzyl ureas provides TRPV1 antagonists with better pharmacokinetic properties and higher effic... Bioorg Med Chem Lett. 2007 Jul 15;17(14):3894-9. DMOTICP RU https://pubmed.ncbi.nlm.nih.gov/17507218 DMHWITR DI DMHWITR DMHWITR DN 1-(isoquinolin-5-yl)-3-(4-morpholinobenzyl)urea DMHWITR MI TTMI6F5 DMHWITR MN Transient receptor potential cation channel V1 (TRPV1) DMHWITR MT DTT DMHWITR MA Inhibitor DMHWITR RN In vitro structure-activity relationship and in vivo characterization of 1-(aryl)-3-(4-(amino)benzyl)urea transient receptor potential vanilloid 1 ... J Med Chem. 2007 Jul 26;50(15):3651-60. DMHWITR RU https://pubmed.ncbi.nlm.nih.gov/17583335 DMI479T DI DMI479T DMI479T DN 1-(METHOXYMETHYL)-6-(NAPHTHALEN-2-YL)-3-AZABICYCLO[4.1.0]HEPTANE (ENANTIOMERIC MIX) DMI479T MI TTXV4FI DMI479T MN Albendazole monooxygenase (CYP3A4) DMI479T MT DTT DMI479T MA Inhibitor DMI479T RN 6-(3,4-dichlorophenyl)-1-[(methyloxy)methyl]-3-azabicyclo[4.1.0]heptane: a new potent and selective triple reuptake inhibitor. J Med Chem. 2010 Jul 8;53(13):4989-5001. DMI479T RU https://pubmed.ncbi.nlm.nih.gov/20527970 DMI479T DI DMI479T DMI479T DN 1-(METHOXYMETHYL)-6-(NAPHTHALEN-2-YL)-3-AZABICYCLO[4.1.0]HEPTANE (ENANTIOMERIC MIX) DMI479T MI TTVG215 DMI479T MN Debrisoquine 4-hydroxylase (CYP2D6) DMI479T MT DTT DMI479T MA Inhibitor DMI479T RN 6-(3,4-dichlorophenyl)-1-[(methyloxy)methyl]-3-azabicyclo[4.1.0]heptane: a new potent and selective triple reuptake inhibitor. J Med Chem. 2010 Jul 8;53(13):4989-5001. DMI479T RU https://pubmed.ncbi.nlm.nih.gov/20527970 DMUEQC8 DI DMUEQC8 DMUEQC8 DN 1-(naphthalen-2-yl)-3-aza-bicyclo[3.1.0]hexane DMUEQC8 MI TTVBI8W DMUEQC8 MN Dopamine transporter (DAT) DMUEQC8 MT DTT DMUEQC8 MA Inhibitor DMUEQC8 RN Studies on the structure-activity relationship of bicifadine analogs as monoamine transporter inhibitors. Bioorg Med Chem Lett. 2008 Jul 1;18(13):3682-6. DMUEQC8 RU https://pubmed.ncbi.nlm.nih.gov/18539031 DMUEQC8 DI DMUEQC8 DMUEQC8 DN 1-(naphthalen-2-yl)-3-aza-bicyclo[3.1.0]hexane DMUEQC8 MI TT3ROYC DMUEQC8 MN Serotonin transporter (SERT) DMUEQC8 MT DTT DMUEQC8 MA Inhibitor DMUEQC8 RN Studies on the structure-activity relationship of bicifadine analogs as monoamine transporter inhibitors. Bioorg Med Chem Lett. 2008 Jul 1;18(13):3682-6. DMUEQC8 RU https://pubmed.ncbi.nlm.nih.gov/18539031 DMXT2ZL DI DMXT2ZL DMXT2ZL DN 1-(oxazol-2-yl)-3-(4-phenoxyphenyl)propan-1-one DMXT2ZL MI TTDP1UC DMXT2ZL MN Fatty acid amide hydrolase (FAAH) DMXT2ZL MT DTT DMXT2ZL MA Inhibitor DMXT2ZL RN Optimization of alpha-ketooxazole inhibitors of fatty acid amide hydrolase. J Med Chem. 2008 Feb 28;51(4):937-47. DMXT2ZL RU https://pubmed.ncbi.nlm.nih.gov/18247553 DMEOS8P DI DMEOS8P DMEOS8P DN 1-(oxazol-2-yl)-4-(piperidin-4-yl)butan-1-one DMEOS8P MI TTDP1UC DMEOS8P MN Fatty acid amide hydrolase (FAAH) DMEOS8P MT DTT DMEOS8P MA Inhibitor DMEOS8P RN Novel ketooxazole based inhibitors of fatty acid amide hydrolase (FAAH). Bioorg Med Chem Lett. 2008 Mar 15;18(6):2109-13. DMEOS8P RU https://pubmed.ncbi.nlm.nih.gov/18289847 DMLKA5O DI DMLKA5O DMLKA5O DN 1-(oxazol-2-yl)-7-phenylheptan-1-one DMLKA5O MI TTDP1UC DMLKA5O MN Fatty acid amide hydrolase (FAAH) DMLKA5O MT DTT DMLKA5O MA Inhibitor DMLKA5O RN Exploration of a fundamental substituent effect of alpha-ketoheterocycle enzyme inhibitors: Potent and selective inhibitors of fatty acid amide hyd... Bioorg Med Chem Lett. 2008 Nov 15;18(22):5842-6. DMLKA5O RU https://pubmed.ncbi.nlm.nih.gov/18639454 DM1ATS3 DI DM1ATS3 DM1ATS3 DN 1-(oxazol-2-yl)octadec-9-en-1-one DM1ATS3 MI TTDP1UC DM1ATS3 MN Fatty acid amide hydrolase (FAAH) DM1ATS3 MT DTT DM1ATS3 MA Inhibitor DM1ATS3 RN Optimization of the central heterocycle of alpha-ketoheterocycle inhibitors of fatty acid amide hydrolase. J Med Chem. 2008 Aug 14;51(15):4392-403. DM1ATS3 RU https://pubmed.ncbi.nlm.nih.gov/18630870 DMT7P2Z DI DMT7P2Z DMT7P2Z DN 1-(oxazolo[4,5-b]pyridin-2-yl)dodecan-1-one DMT7P2Z MI TTDP1UC DMT7P2Z MN Fatty acid amide hydrolase (FAAH) DMT7P2Z MT DTT DMT7P2Z MA Inhibitor DMT7P2Z RN Inhibitors of proteases and amide hydrolases that employ an alpha-ketoheterocycle as a key enabling functionality. Bioorg Med Chem. 2008 Feb 15;16(4):1562-95. DMT7P2Z RU https://pubmed.ncbi.nlm.nih.gov/18053726 DMFGUXZ DI DMFGUXZ DMFGUXZ DN 1-(oxazolo[4,5-b]pyridin-2-yl)octan-1-one DMFGUXZ MI TTDP1UC DMFGUXZ MN Fatty acid amide hydrolase (FAAH) DMFGUXZ MT DTT DMFGUXZ MA Inhibitor DMFGUXZ RN Inhibitors of proteases and amide hydrolases that employ an alpha-ketoheterocycle as a key enabling functionality. Bioorg Med Chem. 2008 Feb 15;16(4):1562-95. DMFGUXZ RU https://pubmed.ncbi.nlm.nih.gov/18053726 DMH2G13 DI DMH2G13 DMH2G13 DN 1-(oxazolo[4,5-b]pyridin-2-yl)pentan-1-one DMH2G13 MI TTDP1UC DMH2G13 MN Fatty acid amide hydrolase (FAAH) DMH2G13 MT DTT DMH2G13 MA Inhibitor DMH2G13 RN Inhibitors of proteases and amide hydrolases that employ an alpha-ketoheterocycle as a key enabling functionality. Bioorg Med Chem. 2008 Feb 15;16(4):1562-95. DMH2G13 RU https://pubmed.ncbi.nlm.nih.gov/18053726 DMJQ7T0 DI DMJQ7T0 DMJQ7T0 DN 1-(pentyloxy)-4-phenoxybenzene DMJQ7T0 MI TTXZEAJ DMJQ7T0 MN Leukotriene A-4 hydrolase (LTA4H) DMJQ7T0 MT DTT DMJQ7T0 MA Inhibitor DMJQ7T0 RN Activation and inhibition of leukotriene A4 hydrolase aminopeptidase activity by diphenyl ether and derivatives. Bioorg Med Chem Lett. 2008 Dec 15;18(24):6549-52. DMJQ7T0 RU https://pubmed.ncbi.nlm.nih.gov/18952425 DMU10CY DI DMU10CY DMU10CY DN 1-(phenyl(p-tolyl)methylene)thiosemicarbazide DMU10CY MI TTF2LRI DMU10CY MN Cathepsin B (CTSB) DMU10CY MT DTT DMU10CY MA Inhibitor DMU10CY RN Discovery of trypanocidal thiosemicarbazone inhibitors of rhodesain and TbcatB. Bioorg Med Chem Lett. 2008 May 1;18(9):2883-5. DMU10CY RU https://pubmed.ncbi.nlm.nih.gov/18420405 DMU10CY DI DMU10CY DMU10CY DN 1-(phenyl(p-tolyl)methylene)thiosemicarbazide DMU10CY MI TT36ETB DMU10CY MN Cathepsin L (CTSL) DMU10CY MT DTT DMU10CY MA Inhibitor DMU10CY RN Discovery of trypanocidal thiosemicarbazone inhibitors of rhodesain and TbcatB. Bioorg Med Chem Lett. 2008 May 1;18(9):2883-5. DMU10CY RU https://pubmed.ncbi.nlm.nih.gov/18420405 DM8APLN DI DM8APLN DM8APLN DN 1-(phenylsulfonyl)-1H-pyrrolo[3,2-b]pyridine DM8APLN MI TTNDSF4 DM8APLN MN Proto-oncogene c-Met (MET) DM8APLN MT DTT DM8APLN MA Inhibitor DM8APLN RN Discovery of 4-azaindoles as novel inhibitors of c-Met kinase. Bioorg Med Chem Lett. 2009 May 15;19(10):2780-4. DM8APLN RU https://pubmed.ncbi.nlm.nih.gov/19369077 DM7W25U DI DM7W25U DM7W25U DN 1-(phenylsulfonyl)-4-(piperazin-1-yl)-1H-indole DM7W25U MI TTJS8PY DM7W25U MN 5-HT 6 receptor (HTR6) DM7W25U MT DTT DM7W25U MA Inhibitor DM7W25U RN Binding of amine-substituted N1-benzenesulfonylindoles at human 5-HT6 serotonin receptors. Bioorg Med Chem Lett. 2005 Dec 1;15(23):5298-302. DM7W25U RU https://pubmed.ncbi.nlm.nih.gov/16183286 DMRGD8W DI DMRGD8W DMRGD8W DN 1-(phenylsulfonyl)butan-2-one DMRGD8W MI TTN7BL9 DMRGD8W MN Corticosteroid 11-beta-dehydrogenase 1 (HSD11B1) DMRGD8W MT DTT DMRGD8W MA Inhibitor DMRGD8W RN beta-Keto sulfones as inhibitors of 11beta-hydroxysteroid dehydrogenase type I and the mechanism of action. Bioorg Med Chem. 2007 Jul 1;15(13):4396-405. DMRGD8W RU https://pubmed.ncbi.nlm.nih.gov/17490884 DMEP80C DI DMEP80C DMEP80C DN 1-(piperazin-1-yl)isoquinoline DMEP80C MI TTWJBZ5 DMEP80C MN 5-HT 2C receptor (HTR2C) DMEP80C MT DTT DMEP80C MA Inhibitor DMEP80C RN Design and synthesis of orally-active and selective azaindane 5HT2c agonist for the treatment of obesity. Bioorg Med Chem Lett. 2010 Jan 1;20(1):266-71. DMEP80C RU https://pubmed.ncbi.nlm.nih.gov/19914063 DMVRN0I DI DMVRN0I DMVRN0I DN 1-(piperidin-3-ylmethyl)pyridin-2(1H)-one DMVRN0I MI TTF4E0J DMVRN0I MN Neuronal acetylcholine receptor alpha-2 (CHRNA2) DMVRN0I MT DTT DMVRN0I MA Inhibitor DMVRN0I RN Synthesis and pharmacological evaluation of novel 9- and 10-substituted cytisine derivatives. Nicotinic ligands of enhanced subtype selectivity. J Med Chem. 2006 May 4;49(9):2673-6. DMVRN0I RU https://pubmed.ncbi.nlm.nih.gov/16640326 DMKQZB7 DI DMKQZB7 DMKQZB7 DN 1-(piperidin-4-ylmethyl)pyridin-2(1H)-one DMKQZB7 MI TTF4E0J DMKQZB7 MN Neuronal acetylcholine receptor alpha-2 (CHRNA2) DMKQZB7 MT DTT DMKQZB7 MA Inhibitor DMKQZB7 RN Synthesis and pharmacological evaluation of novel 9- and 10-substituted cytisine derivatives. Nicotinic ligands of enhanced subtype selectivity. J Med Chem. 2006 May 4;49(9):2673-6. DMKQZB7 RU https://pubmed.ncbi.nlm.nih.gov/16640326 DMO10FD DI DMO10FD DMO10FD DN 1-(Propan-2-ylidene)thiosemicarbazide DMO10FD MI TTULVH8 DMO10FD MN Tyrosinase (TYR) DMO10FD MT DTT DMO10FD MA Inhibitor DMO10FD RN A class of potent tyrosinase inhibitors: alkylidenethiosemicarbazide compounds. Eur J Med Chem. 2009 Apr;44(4):1773-8. DMO10FD RU https://pubmed.ncbi.nlm.nih.gov/18524420 DMKE7FG DI DMKE7FG DMKE7FG DN 1-(pyridin-2-yl)piperazine DMKE7FG MI TTNGILX DMKE7FG MN Adrenergic receptor alpha-1A (ADRA1A) DMKE7FG MT DTT DMKE7FG MA Inhibitor DMKE7FG RN Adrenoceptor and tetrabenazine antagonism activities of some pyridinyltetrahydropyridines. J Med Chem. 1984 Sep;27(9):1182-5. DMKE7FG RU https://pubmed.ncbi.nlm.nih.gov/6088770 DMKE7FG DI DMKE7FG DMKE7FG DN 1-(pyridin-2-yl)piperazine DMKE7FG MI TT34BHT DMKE7FG MN Adrenergic receptor alpha-1D (ADRA1D) DMKE7FG MT DTT DMKE7FG MA Inhibitor DMKE7FG RN Adrenoceptor and tetrabenazine antagonism activities of some pyridinyltetrahydropyridines. J Med Chem. 1984 Sep;27(9):1182-5. DMKE7FG RU https://pubmed.ncbi.nlm.nih.gov/6088770 DMKE7FG DI DMKE7FG DMKE7FG DN 1-(pyridin-2-yl)piperazine DMKE7FG MI TTWG9A4 DMKE7FG MN Adrenergic receptor alpha-2A (ADRA2A) DMKE7FG MT DTT DMKE7FG MA Inhibitor DMKE7FG RN Adrenoceptor and tetrabenazine antagonism activities of some pyridinyltetrahydropyridines. J Med Chem. 1984 Sep;27(9):1182-5. DMKE7FG RU https://pubmed.ncbi.nlm.nih.gov/6088770 DMKE7FG DI DMKE7FG DMKE7FG DN 1-(pyridin-2-yl)piperazine DMKE7FG MI TTWM4TY DMKE7FG MN Adrenergic receptor alpha-2B (ADRA2B) DMKE7FG MT DTT DMKE7FG MA Inhibitor DMKE7FG RN Adrenoceptor and tetrabenazine antagonism activities of some pyridinyltetrahydropyridines. J Med Chem. 1984 Sep;27(9):1182-5. DMKE7FG RU https://pubmed.ncbi.nlm.nih.gov/6088770 DMKE7FG DI DMKE7FG DMKE7FG DN 1-(pyridin-2-yl)piperazine DMKE7FG MI TT3T17P DMKE7FG MN Phospholipase D1 (PLD1) DMKE7FG MT DTT DMKE7FG MA Inhibitor DMKE7FG RN Design and synthesis of isoform-selective phospholipase D (PLD) inhibitors. Part II. Identification of the 1,3,8-triazaspiro[4,5]decan-4-one privil... Bioorg Med Chem Lett. 2009 Apr 15;19(8):2240-3. DMKE7FG RU https://pubmed.ncbi.nlm.nih.gov/19299128 DM78AJ1 DI DM78AJ1 DM78AJ1 DN 1-(pyridin-4-yl)piperazine DM78AJ1 MI TT3T17P DM78AJ1 MN Phospholipase D1 (PLD1) DM78AJ1 MT DTT DM78AJ1 MA Inhibitor DM78AJ1 RN Design and synthesis of isoform-selective phospholipase D (PLD) inhibitors. Part II. Identification of the 1,3,8-triazaspiro[4,5]decan-4-one privil... Bioorg Med Chem Lett. 2009 Apr 15;19(8):2240-3. DM78AJ1 RU https://pubmed.ncbi.nlm.nih.gov/19299128 DM6J1AK DI DM6J1AK DM6J1AK DN 1-(thiophen-2-yl)-3-aza-bicyclo[3.1.0]hexane DM6J1AK MI TTVBI8W DM6J1AK MN Dopamine transporter (DAT) DM6J1AK MT DTT DM6J1AK MA Inhibitor DM6J1AK RN Studies on the structure-activity relationship of bicifadine analogs as monoamine transporter inhibitors. Bioorg Med Chem Lett. 2008 Jul 1;18(13):3682-6. DM6J1AK RU https://pubmed.ncbi.nlm.nih.gov/18539031 DM6J1AK DI DM6J1AK DM6J1AK DN 1-(thiophen-2-yl)-3-aza-bicyclo[3.1.0]hexane DM6J1AK MI TT3ROYC DM6J1AK MN Serotonin transporter (SERT) DM6J1AK MT DTT DM6J1AK MA Inhibitor DM6J1AK RN Studies on the structure-activity relationship of bicifadine analogs as monoamine transporter inhibitors. Bioorg Med Chem Lett. 2008 Jul 1;18(13):3682-6. DM6J1AK RU https://pubmed.ncbi.nlm.nih.gov/18539031 DMD6CHB DI DMD6CHB DMD6CHB DN 1-(trifluoromethyl)-9H-carbazole DMD6CHB MI TTBGTCW DMD6CHB MN Kinesin spindle messenger RNA (KIF11 mRNA) DMD6CHB MT DTT DMD6CHB MA Inhibitor DMD6CHB RN Kinesin spindle protein (KSP) inhibitors with 2,3-fused indole scaffolds. J Med Chem. 2010 Jul 8;53(13):5054-8. DMD6CHB RU https://pubmed.ncbi.nlm.nih.gov/20521839 DMWHN2J DI DMWHN2J DMWHN2J DN 1,1,1,2,2,3,3,5-octafluoro-8-phenyloctan-4-one DMWHN2J MI TTT1JVS DMWHN2J MN Cytosolic phospholipase A2 (GIVA cPLA2) DMWHN2J MT DTT DMWHN2J MA Inhibitor DMWHN2J RN Potent and selective fluoroketone inhibitors of group VIA calcium-independent phospholipase A2. J Med Chem. 2010 May 13;53(9):3602-10. DMWHN2J RU https://pubmed.ncbi.nlm.nih.gov/20369880 DM45NF1 DI DM45NF1 DM45NF1 DN 1,1,1,2,2,3,3-heptafluoro-8-phenyloctan-4-ol DM45NF1 MI TTT1JVS DM45NF1 MN Cytosolic phospholipase A2 (GIVA cPLA2) DM45NF1 MT DTT DM45NF1 MA Inhibitor DM45NF1 RN Potent and selective fluoroketone inhibitors of group VIA calcium-independent phospholipase A2. J Med Chem. 2010 May 13;53(9):3602-10. DM45NF1 RU https://pubmed.ncbi.nlm.nih.gov/20369880 DMN68K4 DI DMN68K4 DMN68K4 DN 1,1,1,2,2,4-hexafluoro-7-phenylheptan-3-one DMN68K4 MI TTT1JVS DMN68K4 MN Cytosolic phospholipase A2 (GIVA cPLA2) DMN68K4 MT DTT DMN68K4 MA Inhibitor DMN68K4 RN Potent and selective fluoroketone inhibitors of group VIA calcium-independent phospholipase A2. J Med Chem. 2010 May 13;53(9):3602-10. DMN68K4 RU https://pubmed.ncbi.nlm.nih.gov/20369880 DM7U8LD DI DM7U8LD DM7U8LD DN 1,1,1,2,2-Pentafluoro-8-phenyl-octan-3-one DM7U8LD MI TTT1JVS DM7U8LD MN Cytosolic phospholipase A2 (GIVA cPLA2) DM7U8LD MT DTT DM7U8LD MA Inhibitor DM7U8LD RN Synthesis of polyfluoro ketones for selective inhibition of human phospholipase A2 enzymes. J Med Chem. 2008 Dec 25;51(24):8027-37. DM7U8LD RU https://pubmed.ncbi.nlm.nih.gov/19053783 DMSEHNV DI DMSEHNV DMSEHNV DN 1,1,1,2,2-Pentafluoro-9-phenyl-nonan-3-one DMSEHNV MI TTT1JVS DMSEHNV MN Cytosolic phospholipase A2 (GIVA cPLA2) DMSEHNV MT DTT DMSEHNV MA Inhibitor DMSEHNV RN Synthesis of polyfluoro ketones for selective inhibition of human phospholipase A2 enzymes. J Med Chem. 2008 Dec 25;51(24):8027-37. DMSEHNV RU https://pubmed.ncbi.nlm.nih.gov/19053783 DMLDH4Z DI DMLDH4Z DMLDH4Z DN 1,1,1,3-Tetrafluoro-6-phenylhexan-2-one DMLDH4Z MI TTT1JVS DMLDH4Z MN Cytosolic phospholipase A2 (GIVA cPLA2) DMLDH4Z MT DTT DMLDH4Z MA Inhibitor DMLDH4Z RN Potent and selective fluoroketone inhibitors of group VIA calcium-independent phospholipase A2. J Med Chem. 2010 May 13;53(9):3602-10. DMLDH4Z RU https://pubmed.ncbi.nlm.nih.gov/20369880 DMV0CXN DI DMV0CXN DMV0CXN DN 1,1,1,3-Tetrafluoro-7-phenylheptan-2-one DMV0CXN MI TTT1JVS DMV0CXN MN Cytosolic phospholipase A2 (GIVA cPLA2) DMV0CXN MT DTT DMV0CXN MA Inhibitor DMV0CXN RN Potent and selective fluoroketone inhibitors of group VIA calcium-independent phospholipase A2. J Med Chem. 2010 May 13;53(9):3602-10. DMV0CXN RU https://pubmed.ncbi.nlm.nih.gov/20369880 DMD36WS DI DMD36WS DMD36WS DN 1,1,1,3-Tetrafluoro-heptadecan-2-one DMD36WS MI TTT1JVS DMD36WS MN Cytosolic phospholipase A2 (GIVA cPLA2) DMD36WS MT DTT DMD36WS MA Inhibitor DMD36WS RN Synthesis of polyfluoro ketones for selective inhibition of human phospholipase A2 enzymes. J Med Chem. 2008 Dec 25;51(24):8027-37. DMD36WS RU https://pubmed.ncbi.nlm.nih.gov/19053783 DMJ0ZMT DI DMJ0ZMT DMJ0ZMT DN 1,1,1-trifluoro-3-(hexylsulfinyl)propan-2-one DMJ0ZMT MI TTMF541 DMJ0ZMT MN Liver carboxylesterase (CES1) DMJ0ZMT MT DTT DMJ0ZMT MA Inhibitor DMJ0ZMT RN Influence of sulfur oxidation state and steric bulk upon trifluoromethyl ketone (TFK) binding kinetics to carboxylesterases and fatty acid amide hy... Bioorg Med Chem. 2008 Feb 15;16(4):2114-30. DMJ0ZMT RU https://pubmed.ncbi.nlm.nih.gov/18023188 DMWDUCH DI DMWDUCH DMWDUCH DN 1,1,1-trifluoro-3-(hexylsulfonyl)propan-2-one DMWDUCH MI TTMF541 DMWDUCH MN Liver carboxylesterase (CES1) DMWDUCH MT DTT DMWDUCH MA Inhibitor DMWDUCH RN Influence of sulfur oxidation state and steric bulk upon trifluoromethyl ketone (TFK) binding kinetics to carboxylesterases and fatty acid amide hy... Bioorg Med Chem. 2008 Feb 15;16(4):2114-30. DMWDUCH RU https://pubmed.ncbi.nlm.nih.gov/18023188 DMWGSP6 DI DMWGSP6 DMWGSP6 DN 1,1,1-trifluoro-3-(hexylthio)propan-2-one DMWGSP6 MI TTDP1UC DMWGSP6 MN Fatty acid amide hydrolase (FAAH) DMWGSP6 MT DTT DMWGSP6 MA Inhibitor DMWGSP6 RN Influence of sulfur oxidation state and steric bulk upon trifluoromethyl ketone (TFK) binding kinetics to carboxylesterases and fatty acid amide hy... Bioorg Med Chem. 2008 Feb 15;16(4):2114-30. DMWGSP6 RU https://pubmed.ncbi.nlm.nih.gov/18023188 DMWGSP6 DI DMWGSP6 DMWGSP6 DN 1,1,1-trifluoro-3-(hexylthio)propan-2-one DMWGSP6 MI TTMF541 DMWGSP6 MN Liver carboxylesterase (CES1) DMWGSP6 MT DTT DMWGSP6 MA Inhibitor DMWGSP6 RN Influence of sulfur oxidation state and steric bulk upon trifluoromethyl ketone (TFK) binding kinetics to carboxylesterases and fatty acid amide hy... Bioorg Med Chem. 2008 Feb 15;16(4):2114-30. DMWGSP6 RU https://pubmed.ncbi.nlm.nih.gov/18023188 DMLBT0E DI DMLBT0E DMLBT0E DN 1,1,1-trifluoro-3-(octylsulfinyl)propan-2-one DMLBT0E MI TTDP1UC DMLBT0E MN Fatty acid amide hydrolase (FAAH) DMLBT0E MT DTT DMLBT0E MA Inhibitor DMLBT0E RN Influence of sulfur oxidation state and steric bulk upon trifluoromethyl ketone (TFK) binding kinetics to carboxylesterases and fatty acid amide hy... Bioorg Med Chem. 2008 Feb 15;16(4):2114-30. DMLBT0E RU https://pubmed.ncbi.nlm.nih.gov/18023188 DMLBT0E DI DMLBT0E DMLBT0E DN 1,1,1-trifluoro-3-(octylsulfinyl)propan-2-one DMLBT0E MI TTMF541 DMLBT0E MN Liver carboxylesterase (CES1) DMLBT0E MT DTT DMLBT0E MA Inhibitor DMLBT0E RN Influence of sulfur oxidation state and steric bulk upon trifluoromethyl ketone (TFK) binding kinetics to carboxylesterases and fatty acid amide hy... Bioorg Med Chem. 2008 Feb 15;16(4):2114-30. DMLBT0E RU https://pubmed.ncbi.nlm.nih.gov/18023188 DMT29SN DI DMT29SN DMT29SN DN 1,1,1-trifluoro-3-(octylsulfonyl)propan-2-one DMT29SN MI TTDP1UC DMT29SN MN Fatty acid amide hydrolase (FAAH) DMT29SN MT DTT DMT29SN MA Inhibitor DMT29SN RN Influence of sulfur oxidation state and steric bulk upon trifluoromethyl ketone (TFK) binding kinetics to carboxylesterases and fatty acid amide hy... Bioorg Med Chem. 2008 Feb 15;16(4):2114-30. DMT29SN RU https://pubmed.ncbi.nlm.nih.gov/18023188 DMT29SN DI DMT29SN DMT29SN DN 1,1,1-trifluoro-3-(octylsulfonyl)propan-2-one DMT29SN MI TTMF541 DMT29SN MN Liver carboxylesterase (CES1) DMT29SN MT DTT DMT29SN MA Inhibitor DMT29SN RN Influence of sulfur oxidation state and steric bulk upon trifluoromethyl ketone (TFK) binding kinetics to carboxylesterases and fatty acid amide hy... Bioorg Med Chem. 2008 Feb 15;16(4):2114-30. DMT29SN RU https://pubmed.ncbi.nlm.nih.gov/18023188 DMU4EJW DI DMU4EJW DMU4EJW DN 1,1,1-trifluoro-3-(octylthio)propan-2-one DMU4EJW MI TTDP1UC DMU4EJW MN Fatty acid amide hydrolase (FAAH) DMU4EJW MT DTT DMU4EJW MA Inhibitor DMU4EJW RN Influence of sulfur oxidation state and steric bulk upon trifluoromethyl ketone (TFK) binding kinetics to carboxylesterases and fatty acid amide hy... Bioorg Med Chem. 2008 Feb 15;16(4):2114-30. DMU4EJW RU https://pubmed.ncbi.nlm.nih.gov/18023188 DMU4EJW DI DMU4EJW DMU4EJW DN 1,1,1-trifluoro-3-(octylthio)propan-2-one DMU4EJW MI TTMF541 DMU4EJW MN Liver carboxylesterase (CES1) DMU4EJW MT DTT DMU4EJW MA Inhibitor DMU4EJW RN Influence of sulfur oxidation state and steric bulk upon trifluoromethyl ketone (TFK) binding kinetics to carboxylesterases and fatty acid amide hy... Bioorg Med Chem. 2008 Feb 15;16(4):2114-30. DMU4EJW RU https://pubmed.ncbi.nlm.nih.gov/18023188 DMODCAM DI DMODCAM DMODCAM DN 1,1,1-Trifluoro-4-(4-hexyloxy-phenyl)-butan-2-one DMODCAM MI TTT1JVS DMODCAM MN Cytosolic phospholipase A2 (GIVA cPLA2) DMODCAM MT DTT DMODCAM MA Inhibitor DMODCAM RN Synthesis of polyfluoro ketones for selective inhibition of human phospholipase A2 enzymes. J Med Chem. 2008 Dec 25;51(24):8027-37. DMODCAM RU https://pubmed.ncbi.nlm.nih.gov/19053783 DMI2XWY DI DMI2XWY DMI2XWY DN 1,1,1-Trifluoro-5-(4-octylphenoxy)pentan-2-one DMI2XWY MI TTT1JVS DMI2XWY MN Cytosolic phospholipase A2 (GIVA cPLA2) DMI2XWY MT DTT DMI2XWY MA Inhibitor DMI2XWY RN Potent and selective fluoroketone inhibitors of group VIA calcium-independent phospholipase A2. J Med Chem. 2010 May 13;53(9):3602-10. DMI2XWY RU https://pubmed.ncbi.nlm.nih.gov/20369880 DMCAQ5T DI DMCAQ5T DMCAQ5T DN 1,1,1-Trifluoro-6-(4-hexyloxy-phenyl)-hexan-2-one DMCAQ5T MI TTT1JVS DMCAQ5T MN Cytosolic phospholipase A2 (GIVA cPLA2) DMCAQ5T MT DTT DMCAQ5T MA Inhibitor DMCAQ5T RN Synthesis of polyfluoro ketones for selective inhibition of human phospholipase A2 enzymes. J Med Chem. 2008 Dec 25;51(24):8027-37. DMCAQ5T RU https://pubmed.ncbi.nlm.nih.gov/19053783 DMZ2VE3 DI DMZ2VE3 DMZ2VE3 DN 1,1,1-Trifluoro-6-(naphthalen-2-yl)hexan-2-one DMZ2VE3 MI TTT1JVS DMZ2VE3 MN Cytosolic phospholipase A2 (GIVA cPLA2) DMZ2VE3 MT DTT DMZ2VE3 MA Inhibitor DMZ2VE3 RN Potent and selective fluoroketone inhibitors of group VIA calcium-independent phospholipase A2. J Med Chem. 2010 May 13;53(9):3602-10. DMZ2VE3 RU https://pubmed.ncbi.nlm.nih.gov/20369880 DMLHVWP DI DMLHVWP DMLHVWP DN 1,1,1-Trifluoro-7-phenylheptan-2-one DMLHVWP MI TTT1JVS DMLHVWP MN Cytosolic phospholipase A2 (GIVA cPLA2) DMLHVWP MT DTT DMLHVWP MA Inhibitor DMLHVWP RN Synthesis of polyfluoro ketones for selective inhibition of human phospholipase A2 enzymes. J Med Chem. 2008 Dec 25;51(24):8027-37. DMLHVWP RU https://pubmed.ncbi.nlm.nih.gov/19053783 DMLHVWP DI DMLHVWP DMLHVWP DN 1,1,1-Trifluoro-7-phenylheptan-2-one DMLHVWP MI TTDP1UC DMLHVWP MN Fatty acid amide hydrolase (FAAH) DMLHVWP MT DTT DMLHVWP MA Inhibitor DMLHVWP RN Discovery of a potent, selective, and efficacious class of reversible alpha-ketoheterocycle inhibitors of fatty acid amide hydrolase effective as a... J Med Chem. 2005 Mar 24;48(6):1849-56. DMLHVWP RU https://pubmed.ncbi.nlm.nih.gov/15771430 DM6GI4Z DI DM6GI4Z DM6GI4Z DN 1,1,1-Trifluoro-8-(4-phenoxy-phenoxy)-octan-2-one DM6GI4Z MI TT6R7JZ DM6GI4Z MN Histone deacetylase 1 (HDAC1) DM6GI4Z MT DTT DM6GI4Z MA Inhibitor DM6GI4Z RN Trifluoromethyl ketones as inhibitors of histone deacetylase. Bioorg Med Chem Lett. 2002 Dec 2;12(23):3443-7. DM6GI4Z RU https://pubmed.ncbi.nlm.nih.gov/12419380 DM6GI4Z DI DM6GI4Z DM6GI4Z DN 1,1,1-Trifluoro-8-(4-phenoxy-phenoxy)-octan-2-one DM6GI4Z MI TTSHTOI DM6GI4Z MN Histone deacetylase 2 (HDAC2) DM6GI4Z MT DTT DM6GI4Z MA Inhibitor DM6GI4Z RN Trifluoromethyl ketones as inhibitors of histone deacetylase. Bioorg Med Chem Lett. 2002 Dec 2;12(23):3443-7. DM6GI4Z RU https://pubmed.ncbi.nlm.nih.gov/12419380 DM41R2O DI DM41R2O DM41R2O DN 1,1,1-Trifluoro-8-phenoxy-octan-2-one DM41R2O MI TT6R7JZ DM41R2O MN Histone deacetylase 1 (HDAC1) DM41R2O MT DTT DM41R2O MA Inhibitor DM41R2O RN Trifluoromethyl ketones as inhibitors of histone deacetylase. Bioorg Med Chem Lett. 2002 Dec 2;12(23):3443-7. DM41R2O RU https://pubmed.ncbi.nlm.nih.gov/12419380 DM41R2O DI DM41R2O DM41R2O DN 1,1,1-Trifluoro-8-phenoxy-octan-2-one DM41R2O MI TTSHTOI DM41R2O MN Histone deacetylase 2 (HDAC2) DM41R2O MT DTT DM41R2O MA Inhibitor DM41R2O RN Trifluoromethyl ketones as inhibitors of histone deacetylase. Bioorg Med Chem Lett. 2002 Dec 2;12(23):3443-7. DM41R2O RU https://pubmed.ncbi.nlm.nih.gov/12419380 DMYENI7 DI DMYENI7 DMYENI7 DN 1,1,1-Trifluoro-8-phenyl-octan-2-one DMYENI7 MI TTT1JVS DMYENI7 MN Cytosolic phospholipase A2 (GIVA cPLA2) DMYENI7 MT DTT DMYENI7 MA Inhibitor DMYENI7 RN Synthesis of polyfluoro ketones for selective inhibition of human phospholipase A2 enzymes. J Med Chem. 2008 Dec 25;51(24):8027-37. DMYENI7 RU https://pubmed.ncbi.nlm.nih.gov/19053783 DMYENI7 DI DMYENI7 DMYENI7 DN 1,1,1-Trifluoro-8-phenyl-octan-2-one DMYENI7 MI TTDP1UC DMYENI7 MN Fatty acid amide hydrolase (FAAH) DMYENI7 MT DTT DMYENI7 MA Inhibitor DMYENI7 RN Discovery of a potent, selective, and efficacious class of reversible alpha-ketoheterocycle inhibitors of fatty acid amide hydrolase effective as a... J Med Chem. 2005 Mar 24;48(6):1849-56. DMYENI7 RU https://pubmed.ncbi.nlm.nih.gov/15771430 DM7DWVL DI DM7DWVL DM7DWVL DN 1,1,1-Trifluoro-9-phenyl-nonan-2-one DM7DWVL MI TTDP1UC DM7DWVL MN Fatty acid amide hydrolase (FAAH) DM7DWVL MT DTT DM7DWVL MA Inhibitor DM7DWVL RN Discovery of a potent, selective, and efficacious class of reversible alpha-ketoheterocycle inhibitors of fatty acid amide hydrolase effective as a... J Med Chem. 2005 Mar 24;48(6):1849-56. DM7DWVL RU https://pubmed.ncbi.nlm.nih.gov/15771430 DMW6CQV DI DMW6CQV DMW6CQV DN 1,1,1-trifluorododecan-2-one DMW6CQV MI TTDP1UC DMW6CQV MN Fatty acid amide hydrolase (FAAH) DMW6CQV MT DTT DMW6CQV MA Inhibitor DMW6CQV RN Influence of sulfur oxidation state and steric bulk upon trifluoromethyl ketone (TFK) binding kinetics to carboxylesterases and fatty acid amide hy... Bioorg Med Chem. 2008 Feb 15;16(4):2114-30. DMW6CQV RU https://pubmed.ncbi.nlm.nih.gov/18023188 DMW6CQV DI DMW6CQV DMW6CQV DN 1,1,1-trifluorododecan-2-one DMW6CQV MI TTMF541 DMW6CQV MN Liver carboxylesterase (CES1) DMW6CQV MT DTT DMW6CQV MA Inhibitor DMW6CQV RN Influence of sulfur oxidation state and steric bulk upon trifluoromethyl ketone (TFK) binding kinetics to carboxylesterases and fatty acid amide hy... Bioorg Med Chem. 2008 Feb 15;16(4):2114-30. DMW6CQV RU https://pubmed.ncbi.nlm.nih.gov/18023188 DMB5U3P DI DMB5U3P DMB5U3P DN 1,1,1-trifluoroheptadecan-2-one DMB5U3P MI TTT1JVS DMB5U3P MN Cytosolic phospholipase A2 (GIVA cPLA2) DMB5U3P MT DTT DMB5U3P MA Inhibitor DMB5U3P RN Synthesis of polyfluoro ketones for selective inhibition of human phospholipase A2 enzymes. J Med Chem. 2008 Dec 25;51(24):8027-37. DMB5U3P RU https://pubmed.ncbi.nlm.nih.gov/19053783 DM8TWY7 DI DM8TWY7 DM8TWY7 DN 1,1,1-Trifluoro-nonadecan-2-one DM8TWY7 MI TTDP1UC DM8TWY7 MN Fatty acid amide hydrolase (FAAH) DM8TWY7 MT DTT DM8TWY7 MA Inhibitor DM8TWY7 RN Discovery of a potent, selective, and efficacious class of reversible alpha-ketoheterocycle inhibitors of fatty acid amide hydrolase effective as a... J Med Chem. 2005 Mar 24;48(6):1849-56. DM8TWY7 RU https://pubmed.ncbi.nlm.nih.gov/15771430 DM4CEQP DI DM4CEQP DM4CEQP DN 1,1,1-Trifluoro-tridecan-2-one DM4CEQP MI TTDP1UC DM4CEQP MN Fatty acid amide hydrolase (FAAH) DM4CEQP MT DTT DM4CEQP MA Inhibitor DM4CEQP RN Discovery of a potent, selective, and efficacious class of reversible alpha-ketoheterocycle inhibitors of fatty acid amide hydrolase effective as a... J Med Chem. 2005 Mar 24;48(6):1849-56. DM4CEQP RU https://pubmed.ncbi.nlm.nih.gov/15771430 DMX2SFW DI DMX2SFW DMX2SFW DN 1,1,1-Trifluoro-undecan-2-one DMX2SFW MI TTDP1UC DMX2SFW MN Fatty acid amide hydrolase (FAAH) DMX2SFW MT DTT DMX2SFW MA Inhibitor DMX2SFW RN Discovery of a potent, selective, and efficacious class of reversible alpha-ketoheterocycle inhibitors of fatty acid amide hydrolase effective as a... J Med Chem. 2005 Mar 24;48(6):1849-56. DMX2SFW RU https://pubmed.ncbi.nlm.nih.gov/15771430 DMGHAC7 DI DMGHAC7 DMGHAC7 DN 1,1':4',1''-terphenyl-3,3''-diol DMGHAC7 MI TTXV4FI DMGHAC7 MN Albendazole monooxygenase (CYP3A4) DMGHAC7 MT DTT DMGHAC7 MA Inhibitor DMGHAC7 RN Design, synthesis, biological evaluation and pharmacokinetics of bis(hydroxyphenyl) substituted azoles, thiophenes, benzenes, and aza-benzenes as p... J Med Chem. 2008 Nov 13;51(21):6725-39. DMGHAC7 RU https://pubmed.ncbi.nlm.nih.gov/18855374 DMGHAC7 DI DMGHAC7 DMGHAC7 DN 1,1':4',1''-terphenyl-3,3''-diol DMGHAC7 MI TTIWB6L DMGHAC7 MN Estradiol 17 beta-dehydrogenase 1 (17-beta-HSD1) DMGHAC7 MT DTT DMGHAC7 MA Inhibitor DMGHAC7 RN New insights into the SAR and binding modes of bis(hydroxyphenyl)thiophenes and -benzenes: influence of additional substituents on 17beta-hydroxyst... J Med Chem. 2009 Nov 12;52(21):6724-43. DMGHAC7 RU https://pubmed.ncbi.nlm.nih.gov/19831396 DMA3LZ9 DI DMA3LZ9 DMA3LZ9 DN 1,1':4',1''-terphenyl-3,4''-diol DMA3LZ9 MI TTIWB6L DMA3LZ9 MN Estradiol 17 beta-dehydrogenase 1 (17-beta-HSD1) DMA3LZ9 MT DTT DMA3LZ9 MA Inhibitor DMA3LZ9 RN New insights into the SAR and binding modes of bis(hydroxyphenyl)thiophenes and -benzenes: influence of additional substituents on 17beta-hydroxyst... J Med Chem. 2009 Nov 12;52(21):6724-43. DMA3LZ9 RU https://pubmed.ncbi.nlm.nih.gov/19831396 DMYVBD2 DI DMYVBD2 DMYVBD2 DN 1,10-(methylenedi-4,1-phenylene)bismaleimide DMYVBD2 MI TTDP1UC DMYVBD2 MN Fatty acid amide hydrolase (FAAH) DMYVBD2 MT DTT DMYVBD2 MA Inhibitor DMYVBD2 RN Synthesis and in vitro evaluation of N-substituted maleimide derivatives as selective monoglyceride lipase inhibitors. J Med Chem. 2009 Dec 10;52(23):7410-20. DMYVBD2 RU https://pubmed.ncbi.nlm.nih.gov/19583260 DM9UGFQ DI DM9UGFQ DM9UGFQ DN 1,10-bis-(Dmt-Tic-amino)decane DM9UGFQ MI TT27RFC DM9UGFQ MN Opioid receptor delta (OPRD1) DM9UGFQ MT DTT DM9UGFQ MA Inhibitor DM9UGFQ RN Potent Dmt-Tic pharmacophoric delta- and mu-opioid receptor antagonists. J Med Chem. 2005 Dec 15;48(25):8035-44. DM9UGFQ RU https://pubmed.ncbi.nlm.nih.gov/16335927 DM9UGFQ DI DM9UGFQ DM9UGFQ DN 1,10-bis-(Dmt-Tic-amino)decane DM9UGFQ MI TTKWM86 DM9UGFQ MN Opioid receptor mu (MOP) DM9UGFQ MT DTT DM9UGFQ MA Inhibitor DM9UGFQ RN Potent Dmt-Tic pharmacophoric delta- and mu-opioid receptor antagonists. J Med Chem. 2005 Dec 15;48(25):8035-44. DM9UGFQ RU https://pubmed.ncbi.nlm.nih.gov/16335927 DM6VCI3 DI DM6VCI3 DM6VCI3 DN 1,10-bis(pyridinium)-decane dibromide DM6VCI3 MI TT1RS9F DM6VCI3 MN Acetylcholinesterase (AChE) DM6VCI3 MT DTT DM6VCI3 MA Inhibitor DM6VCI3 RN Preparation and in vitro screening of symmetrical bispyridinium cholinesterase inhibitors bearing different connecting linkage-initial study for My... Bioorg Med Chem Lett. 2010 Mar 1;20(5):1763-6. DM6VCI3 RU https://pubmed.ncbi.nlm.nih.gov/20138518 DM6VCI3 DI DM6VCI3 DM6VCI3 DN 1,10-bis(pyridinium)-decane dibromide DM6VCI3 MI TTEB0GD DM6VCI3 MN Cholinesterase (BCHE) DM6VCI3 MT DTT DM6VCI3 MA Inhibitor DM6VCI3 RN Preparation and in vitro screening of symmetrical bispyridinium cholinesterase inhibitors bearing different connecting linkage-initial study for My... Bioorg Med Chem Lett. 2010 Mar 1;20(5):1763-6. DM6VCI3 RU https://pubmed.ncbi.nlm.nih.gov/20138518 DM5LVD2 DI DM5LVD2 DM5LVD2 DN 1,10-phenanthroline-5,6-dione DM5LVD2 MI TTMF541 DM5LVD2 MN Liver carboxylesterase (CES1) DM5LVD2 MT DTT DM5LVD2 MA Inhibitor DM5LVD2 RN Planarity and constraint of the carbonyl groups in 1,2-diones are determinants for selective inhibition of human carboxylesterase 1. J Med Chem. 2007 Nov 15;50(23):5727-34. DM5LVD2 RU https://pubmed.ncbi.nlm.nih.gov/17941623 DMVXYZL DI DMVXYZL DMVXYZL DN 1,11-bis(pyridinium)-undecane dibromide DMVXYZL MI TT1RS9F DMVXYZL MN Acetylcholinesterase (AChE) DMVXYZL MT DTT DMVXYZL MA Inhibitor DMVXYZL RN Preparation and in vitro screening of symmetrical bispyridinium cholinesterase inhibitors bearing different connecting linkage-initial study for My... Bioorg Med Chem Lett. 2010 Mar 1;20(5):1763-6. DMVXYZL RU https://pubmed.ncbi.nlm.nih.gov/20138518 DMVXYZL DI DMVXYZL DMVXYZL DN 1,11-bis(pyridinium)-undecane dibromide DMVXYZL MI TTEB0GD DMVXYZL MN Cholinesterase (BCHE) DMVXYZL MT DTT DMVXYZL MA Inhibitor DMVXYZL RN Preparation and in vitro screening of symmetrical bispyridinium cholinesterase inhibitors bearing different connecting linkage-initial study for My... Bioorg Med Chem Lett. 2010 Mar 1;20(5):1763-6. DMVXYZL RU https://pubmed.ncbi.nlm.nih.gov/20138518 DMG362U DI DMG362U DMG362U DN 1,1-bisphosphonate esters DMG362U MI TTS4UGC DMG362U MN Farnesoid X-activated receptor (FXR) DMG362U MT DTT DMG362U MA Agonist DMG362U RN The nuclear receptors FXR and LXRalpha: potential targets for the development of drugs affecting lipid metabolism and neoplastic diseases. Curr Pharm Des. 2001 Mar;7(4):231-59. DMG362U RU https://pubmed.ncbi.nlm.nih.gov/11254888 DM9XTY7 DI DM9XTY7 DM9XTY7 DN 1,1-Dimethyl-4-phenyl-piperazin-1-ium iodide DM9XTY7 MI TTF4E0J DM9XTY7 MN Neuronal acetylcholine receptor alpha-2 (CHRNA2) DM9XTY7 MT DTT DM9XTY7 MA Inhibitor DM9XTY7 RN Pharmacology of the agonist binding sites of rat neuronal nicotinic receptor subtypes expressed in HEK 293 cells. Bioorg Med Chem Lett. 2004 Apr 19;14(8):1845-8. DM9XTY7 RU https://pubmed.ncbi.nlm.nih.gov/15050613 DMOGHRS DI DMOGHRS DMOGHRS DN 1,1-Dimethyl-5-oxa-spiro[2.4]heptan-4-one DMOGHRS MI TT1MPAY DMOGHRS MN GABA(A) receptor alpha-1 (GABRA1) DMOGHRS MT DTT DMOGHRS MA Inhibitor DMOGHRS RN Alpha-spirocyclopentyl- and alpha-spirocyclopropyl-gamma-butyrolactones: conformationally constrained derivatives of anticonvulsant and convulsant ... J Med Chem. 1994 Jan 21;37(2):275-86. DMOGHRS RU https://pubmed.ncbi.nlm.nih.gov/8295215 DMOGHRS DI DMOGHRS DMOGHRS DN 1,1-Dimethyl-5-oxa-spiro[2.4]heptan-4-one DMOGHRS MI TTZA1NY DMOGHRS MN GABA(A) receptor beta-2 (GABRB2) DMOGHRS MT DTT DMOGHRS MA Inhibitor DMOGHRS RN Alpha-spirocyclopentyl- and alpha-spirocyclopropyl-gamma-butyrolactones: conformationally constrained derivatives of anticonvulsant and convulsant ... J Med Chem. 1994 Jan 21;37(2):275-86. DMOGHRS RU https://pubmed.ncbi.nlm.nih.gov/8295215 DMOGHRS DI DMOGHRS DMOGHRS DN 1,1-Dimethyl-5-oxa-spiro[2.4]heptan-4-one DMOGHRS MI TT06RH5 DMOGHRS MN GABA(A) receptor gamma-2 (GABRG2) DMOGHRS MT DTT DMOGHRS MA Inhibitor DMOGHRS RN Alpha-spirocyclopentyl- and alpha-spirocyclopropyl-gamma-butyrolactones: conformationally constrained derivatives of anticonvulsant and convulsant ... J Med Chem. 1994 Jan 21;37(2):275-86. DMOGHRS RU https://pubmed.ncbi.nlm.nih.gov/8295215 DMOGHRS DI DMOGHRS DMOGHRS DN 1,1-Dimethyl-5-oxa-spiro[2.4]heptan-4-one DMOGHRS MI TTNJYV2 DMOGHRS MN Gamma-aminobutyric acid receptor (GAR) DMOGHRS MT DTT DMOGHRS MA Inhibitor DMOGHRS RN Alpha-spirocyclopentyl- and alpha-spirocyclopropyl-gamma-butyrolactones: conformationally constrained derivatives of anticonvulsant and convulsant ... J Med Chem. 1994 Jan 21;37(2):275-86. DMOGHRS RU https://pubmed.ncbi.nlm.nih.gov/8295215 DMZDUSA DI DMZDUSA DMZDUSA DN 1,1-diphenyl-2-(3-tropanyl)ethanol DMZDUSA MI TTZ9SOR DMZDUSA MN Muscarinic acetylcholine receptor M1 (CHRM1) DMZDUSA MT DTT DMZDUSA MA Inhibitor DMZDUSA RN Discovery of (3-endo)-3-(2-cyano-2,2-diphenylethyl)-8,8-dimethyl-8-azoniabicyclo[3.2.1]octane bromide as an efficacious inhaled muscarinic acetylch... Bioorg Med Chem Lett. 2009 Aug 15;19(16):4560-2. DMZDUSA RU https://pubmed.ncbi.nlm.nih.gov/19616944 DMZDUSA DI DMZDUSA DMZDUSA DN 1,1-diphenyl-2-(3-tropanyl)ethanol DMZDUSA MI TTYEG6Q DMZDUSA MN Muscarinic acetylcholine receptor M2 (CHRM2) DMZDUSA MT DTT DMZDUSA MA Inhibitor DMZDUSA RN Discovery of (3-endo)-3-(2-cyano-2,2-diphenylethyl)-8,8-dimethyl-8-azoniabicyclo[3.2.1]octane bromide as an efficacious inhaled muscarinic acetylch... Bioorg Med Chem Lett. 2009 Aug 15;19(16):4560-2. DMZDUSA RU https://pubmed.ncbi.nlm.nih.gov/19616944 DMZDUSA DI DMZDUSA DMZDUSA DN 1,1-diphenyl-2-(3-tropanyl)ethanol DMZDUSA MI TTQ13Z5 DMZDUSA MN Muscarinic acetylcholine receptor M3 (CHRM3) DMZDUSA MT DTT DMZDUSA MA Inhibitor DMZDUSA RN Discovery of (3-endo)-3-(2-cyano-2,2-diphenylethyl)-8,8-dimethyl-8-azoniabicyclo[3.2.1]octane bromide as an efficacious inhaled muscarinic acetylch... Bioorg Med Chem Lett. 2009 Aug 15;19(16):4560-2. DMZDUSA RU https://pubmed.ncbi.nlm.nih.gov/19616944 DM7SQ4H DI DM7SQ4H DM7SQ4H DN 1,1-diphenyl-3-(phenylsulfonyl)propan-2-one DM7SQ4H MI TTN7BL9 DM7SQ4H MN Corticosteroid 11-beta-dehydrogenase 1 (HSD11B1) DM7SQ4H MT DTT DM7SQ4H MA Inhibitor DM7SQ4H RN beta-Keto sulfones as inhibitors of 11beta-hydroxysteroid dehydrogenase type I and the mechanism of action. Bioorg Med Chem. 2007 Jul 1;15(13):4396-405. DM7SQ4H RU https://pubmed.ncbi.nlm.nih.gov/17490884 DMDYX7P DI DMDYX7P DMDYX7P DN 1,2,3,4,4a,5,10,10a-Octahydro-benzo[g]quinoline DMDYX7P MI TTWG9A4 DMDYX7P MN Adrenergic receptor alpha-2A (ADRA2A) DMDYX7P MT DTT DMDYX7P MA Inhibitor DMDYX7P RN N-(Iodopropenyl)-octahydrobenzo[f]- and -[g]quinolines: synthesis and adrenergic and dopaminergic activity studies. J Med Chem. 1998 Oct 8;41(21):4165-70. DMDYX7P RU https://pubmed.ncbi.nlm.nih.gov/9767652 DMDYX7P DI DMDYX7P DMDYX7P DN 1,2,3,4,4a,5,10,10a-Octahydro-benzo[g]quinoline DMDYX7P MI TTWM4TY DMDYX7P MN Adrenergic receptor alpha-2B (ADRA2B) DMDYX7P MT DTT DMDYX7P MA Inhibitor DMDYX7P RN N-(Iodopropenyl)-octahydrobenzo[f]- and -[g]quinolines: synthesis and adrenergic and dopaminergic activity studies. J Med Chem. 1998 Oct 8;41(21):4165-70. DMDYX7P RU https://pubmed.ncbi.nlm.nih.gov/9767652 DMDYX7P DI DMDYX7P DMDYX7P DN 1,2,3,4,4a,5,10,10a-Octahydro-benzo[g]quinoline DMDYX7P MI TT2NUT5 DMDYX7P MN Adrenergic receptor alpha-2C (ADRA2C) DMDYX7P MT DTT DMDYX7P MA Inhibitor DMDYX7P RN N-(Iodopropenyl)-octahydrobenzo[f]- and -[g]quinolines: synthesis and adrenergic and dopaminergic activity studies. J Med Chem. 1998 Oct 8;41(21):4165-70. DMDYX7P RU https://pubmed.ncbi.nlm.nih.gov/9767652 DM7JMCI DI DM7JMCI DM7JMCI DN 1,2,3,4,4a,5-hexahydrophenanthridin-6(10bH)-one DM7JMCI MI TTVDSZ0 DM7JMCI MN Poly [ADP-ribose] polymerase 1 (PARP1) DM7JMCI MT DTT DM7JMCI MA Inhibitor DM7JMCI RN Design, synthesis, and cytoprotective effect of 2-aminothiazole analogues as potent poly(ADP-ribose) polymerase-1 inhibitors. J Med Chem. 2009 Feb 12;52(3):718-25. DM7JMCI RU https://pubmed.ncbi.nlm.nih.gov/19125579 DMVD702 DI DMVD702 DMVD702 DN 1,2,3,4,5,6-hexabromocyclohexane DMVD702 MI TTRMX3V DMVD702 MN Janus kinase 2 (JAK-2) DMVD702 MT DTT DMVD702 MA Inhibitor DMVD702 RN Identification of 1,2,3,4,5,6-hexabromocyclohexane as a small molecule inhibitor of jak2 tyrosine kinase autophosphorylation [correction of autophophorylation]. J Med Chem. 2005 Apr 7;48(7):2526-33. DMVD702 RU https://pubmed.ncbi.nlm.nih.gov/15801842 DMTKYFE DI DMTKYFE DMTKYFE DN 1,2,3,4,5,6-Hexahydro-benzo[c]azocine DMTKYFE MI TTWG9A4 DMTKYFE MN Adrenergic receptor alpha-2A (ADRA2A) DMTKYFE MT DTT DMTKYFE MA Inhibitor DMTKYFE RN Effect of ring size or an additional heteroatom on the potency and selectivity of bicyclic benzylamine-type inhibitors of phenylethanolamine N-meth... J Med Chem. 1996 Aug 30;39(18):3539-46. DMTKYFE RU https://pubmed.ncbi.nlm.nih.gov/8784452 DMTKYFE DI DMTKYFE DMTKYFE DN 1,2,3,4,5,6-Hexahydro-benzo[c]azocine DMTKYFE MI TTWM4TY DMTKYFE MN Adrenergic receptor alpha-2B (ADRA2B) DMTKYFE MT DTT DMTKYFE MA Inhibitor DMTKYFE RN Effect of ring size or an additional heteroatom on the potency and selectivity of bicyclic benzylamine-type inhibitors of phenylethanolamine N-meth... J Med Chem. 1996 Aug 30;39(18):3539-46. DMTKYFE RU https://pubmed.ncbi.nlm.nih.gov/8784452 DMTKYFE DI DMTKYFE DMTKYFE DN 1,2,3,4,5,6-Hexahydro-benzo[c]azocine DMTKYFE MI TT2NUT5 DMTKYFE MN Adrenergic receptor alpha-2C (ADRA2C) DMTKYFE MT DTT DMTKYFE MA Inhibitor DMTKYFE RN Effect of ring size or an additional heteroatom on the potency and selectivity of bicyclic benzylamine-type inhibitors of phenylethanolamine N-meth... J Med Chem. 1996 Aug 30;39(18):3539-46. DMTKYFE RU https://pubmed.ncbi.nlm.nih.gov/8784452 DMTK650 DI DMTK650 DMTK650 DN 1,2,3,4,6-penta-O-galloyl-beta-D-glucose DMTK650 MI TT6L509 DMTK650 MN Coagulation factor IIa (F2) DMTK650 MT DTT DMTK650 MA Inhibitor DMTK650 RN Effects of tannins from Geum japonicum on the catalytic activity of thrombin and factor Xa of blood coagulation cascade. J Nat Prod. 1998 Nov;61(11):1356-60. DMTK650 RU https://pubmed.ncbi.nlm.nih.gov/9834152 DMTK650 DI DMTK650 DMTK650 DN 1,2,3,4,6-penta-O-galloyl-beta-D-glucose DMTK650 MI TTCIHJA DMTK650 MN Coagulation factor Xa (F10) DMTK650 MT DTT DMTK650 MA Inhibitor DMTK650 RN Effects of tannins from Geum japonicum on the catalytic activity of thrombin and factor Xa of blood coagulation cascade. J Nat Prod. 1998 Nov;61(11):1356-60. DMTK650 RU https://pubmed.ncbi.nlm.nih.gov/9834152 DMTK650 DI DMTK650 DMTK650 DN 1,2,3,4,6-penta-O-galloyl-beta-D-glucose DMTK650 MI TTE14XG DMTK650 MN Squalene monooxygenase (SQLE) DMTK650 MT DTT DMTK650 MA Inhibitor DMTK650 RN Ellagitannins and hexahydroxydiphenoyl esters as inhibitors of vertebrate squalene epoxidase. J Nat Prod. 2001 Aug;64(8):1010-4. DMTK650 RU https://pubmed.ncbi.nlm.nih.gov/11520216 DMTK650 DI DMTK650 DMTK650 DN 1,2,3,4,6-penta-O-galloyl-beta-D-glucose DMTK650 MI TT7RJY8 DMTK650 MN Xanthine dehydrogenase/oxidase (XDH) DMTK650 MT DTT DMTK650 MA Inhibitor DMTK650 RN Pentagalloylglucose, a xanthine oxidase inhibitor from a Paraguayan crude drug, "Molle-i" (Schinus terebinthifolius). J Nat Prod. 1989 Jan-Feb;52(1):210-1. DMTK650 RU https://pubmed.ncbi.nlm.nih.gov/2723668 DM9ICSA DI DM9ICSA DM9ICSA DN 1,2,3,4,6-penta-O-galloyl-D-glucopyranose DM9ICSA MI TTELIN2 DM9ICSA MN PTPN1 messenger RNA (PTPN1 mRNA) DM9ICSA MT DTT DM9ICSA MA Inhibitor DM9ICSA RN Bioactivity-guided isolation of 1,2,3,4,6-Penta-O-galloyl-D-glucopyranose from Paeonia lactiflora roots as a PTP1B inhibitor. J Nat Prod. 2010 Sep 24;73(9):1578-81. DM9ICSA RU https://pubmed.ncbi.nlm.nih.gov/20806783 DMHKANE DI DMHKANE DMHKANE DN 1,2,3,4-Tetrahydro-benzo[h]isoquinolin-8-ol DMHKANE MI TTWG9A4 DMHKANE MN Adrenergic receptor alpha-2A (ADRA2A) DMHKANE MT DTT DMHKANE MA Inhibitor DMHKANE RN Examination of the role of the acidic hydrogen in imparting selectivity of 7-(aminosulfonyl)-1,2,3,4-tetrahydroisoquinoline (SK&F 29661) toward inh... J Med Chem. 1997 Dec 5;40(25):3997-4005. DMHKANE RU https://pubmed.ncbi.nlm.nih.gov/9406590 DMHKANE DI DMHKANE DMHKANE DN 1,2,3,4-Tetrahydro-benzo[h]isoquinolin-8-ol DMHKANE MI TTWM4TY DMHKANE MN Adrenergic receptor alpha-2B (ADRA2B) DMHKANE MT DTT DMHKANE MA Inhibitor DMHKANE RN Examination of the role of the acidic hydrogen in imparting selectivity of 7-(aminosulfonyl)-1,2,3,4-tetrahydroisoquinoline (SK&F 29661) toward inh... J Med Chem. 1997 Dec 5;40(25):3997-4005. DMHKANE RU https://pubmed.ncbi.nlm.nih.gov/9406590 DMHKANE DI DMHKANE DMHKANE DN 1,2,3,4-Tetrahydro-benzo[h]isoquinolin-8-ol DMHKANE MI TT2NUT5 DMHKANE MN Adrenergic receptor alpha-2C (ADRA2C) DMHKANE MT DTT DMHKANE MA Inhibitor DMHKANE RN Examination of the role of the acidic hydrogen in imparting selectivity of 7-(aminosulfonyl)-1,2,3,4-tetrahydroisoquinoline (SK&F 29661) toward inh... J Med Chem. 1997 Dec 5;40(25):3997-4005. DMHKANE RU https://pubmed.ncbi.nlm.nih.gov/9406590 DM5VLIE DI DM5VLIE DM5VLIE DN 1,2,3,4-Tetrahydro-isoquinolin-7-ol DM5VLIE MI TTWG9A4 DM5VLIE MN Adrenergic receptor alpha-2A (ADRA2A) DM5VLIE MT DTT DM5VLIE MA Inhibitor DM5VLIE RN Examination of the role of the acidic hydrogen in imparting selectivity of 7-(aminosulfonyl)-1,2,3,4-tetrahydroisoquinoline (SK&F 29661) toward inh... J Med Chem. 1997 Dec 5;40(25):3997-4005. DM5VLIE RU https://pubmed.ncbi.nlm.nih.gov/9406590 DM5VLIE DI DM5VLIE DM5VLIE DN 1,2,3,4-Tetrahydro-isoquinolin-7-ol DM5VLIE MI TTWM4TY DM5VLIE MN Adrenergic receptor alpha-2B (ADRA2B) DM5VLIE MT DTT DM5VLIE MA Inhibitor DM5VLIE RN Examination of the role of the acidic hydrogen in imparting selectivity of 7-(aminosulfonyl)-1,2,3,4-tetrahydroisoquinoline (SK&F 29661) toward inh... J Med Chem. 1997 Dec 5;40(25):3997-4005. DM5VLIE RU https://pubmed.ncbi.nlm.nih.gov/9406590 DM5VLIE DI DM5VLIE DM5VLIE DN 1,2,3,4-Tetrahydro-isoquinolin-7-ol DM5VLIE MI TT2NUT5 DM5VLIE MN Adrenergic receptor alpha-2C (ADRA2C) DM5VLIE MT DTT DM5VLIE MA Inhibitor DM5VLIE RN Examination of the role of the acidic hydrogen in imparting selectivity of 7-(aminosulfonyl)-1,2,3,4-tetrahydroisoquinoline (SK&F 29661) toward inh... J Med Chem. 1997 Dec 5;40(25):3997-4005. DM5VLIE RU https://pubmed.ncbi.nlm.nih.gov/9406590 DMZGCEQ DI DMZGCEQ DMZGCEQ DN 1,2,3,4-tetrahydroisoquinoline DMZGCEQ MI TTWG9A4 DMZGCEQ MN Adrenergic receptor alpha-2A (ADRA2A) DMZGCEQ MT DTT DMZGCEQ MA Inhibitor DMZGCEQ RN Comparison of the binding of 3-fluoromethyl-7-sulfonyl-1,2,3,4-tetrahydroisoquinolines with their isosteric sulfonamides to the active site of phen... J Med Chem. 2006 Sep 7;49(18):5424-33. DMZGCEQ RU https://pubmed.ncbi.nlm.nih.gov/16942016 DMZGCEQ DI DMZGCEQ DMZGCEQ DN 1,2,3,4-tetrahydroisoquinoline DMZGCEQ MI TTWM4TY DMZGCEQ MN Adrenergic receptor alpha-2B (ADRA2B) DMZGCEQ MT DTT DMZGCEQ MA Inhibitor DMZGCEQ RN Comparison of the binding of 3-fluoromethyl-7-sulfonyl-1,2,3,4-tetrahydroisoquinolines with their isosteric sulfonamides to the active site of phen... J Med Chem. 2006 Sep 7;49(18):5424-33. DMZGCEQ RU https://pubmed.ncbi.nlm.nih.gov/16942016 DMZGCEQ DI DMZGCEQ DMZGCEQ DN 1,2,3,4-tetrahydroisoquinoline DMZGCEQ MI TT2NUT5 DMZGCEQ MN Adrenergic receptor alpha-2C (ADRA2C) DMZGCEQ MT DTT DMZGCEQ MA Inhibitor DMZGCEQ RN Comparison of the binding of 3-fluoromethyl-7-sulfonyl-1,2,3,4-tetrahydroisoquinolines with their isosteric sulfonamides to the active site of phen... J Med Chem. 2006 Sep 7;49(18):5424-33. DMZGCEQ RU https://pubmed.ncbi.nlm.nih.gov/16942016 DMNXQ7Z DI DMNXQ7Z DMNXQ7Z DN 1,2,3,4-Tetrahydro-naphthalen-1-ylamine DMNXQ7Z MI TTGP7BY DMNXQ7Z MN Monoamine oxidase type B (MAO-B) DMNXQ7Z MT DTT DMNXQ7Z MA Inhibitor DMNXQ7Z RN Stereoisomers of allenic amines as inactivators of monoamine oxidase type B. Stereochemical probes of the active site. J Med Chem. 1988 Aug;31(8):1558-66. DMNXQ7Z RU https://pubmed.ncbi.nlm.nih.gov/3397993 DMP4DLV DI DMP4DLV DMP4DLV DN 1,2,3,4-Tetrahydro-naphthalen-2-ylamine DMP4DLV MI TTSQIFT DMP4DLV MN 5-HT 1A receptor (HTR1A) DMP4DLV MT DTT DMP4DLV MA Inhibitor DMP4DLV RN 5-HT1 and 5-HT2 binding characteristics of some quipazine analogues. J Med Chem. 1986 Nov;29(11):2375-80. DMP4DLV RU https://pubmed.ncbi.nlm.nih.gov/3783595 DMP4DLV DI DMP4DLV DMP4DLV DN 1,2,3,4-Tetrahydro-naphthalen-2-ylamine DMP4DLV MI TT6MSOK DMP4DLV MN 5-HT 1D receptor (HTR1D) DMP4DLV MT DTT DMP4DLV MA Inhibitor DMP4DLV RN 5-HT1 and 5-HT2 binding characteristics of some quipazine analogues. J Med Chem. 1986 Nov;29(11):2375-80. DMP4DLV RU https://pubmed.ncbi.nlm.nih.gov/3783595 DMP4DLV DI DMP4DLV DMP4DLV DN 1,2,3,4-Tetrahydro-naphthalen-2-ylamine DMP4DLV MI TTJQOD7 DMP4DLV MN 5-HT 2A receptor (HTR2A) DMP4DLV MT DTT DMP4DLV MA Inhibitor DMP4DLV RN 5-HT1 and 5-HT2 binding characteristics of some quipazine analogues. J Med Chem. 1986 Nov;29(11):2375-80. DMP4DLV RU https://pubmed.ncbi.nlm.nih.gov/3783595 DM3JGVF DI DM3JGVF DM3JGVF DN 1,2,3,4-Tetrahydro-pyrazino[1,2-a]indole DM3JGVF MI TTJQOD7 DM3JGVF MN 5-HT 2A receptor (HTR2A) DM3JGVF MT DTT DM3JGVF MA Inhibitor DM3JGVF RN Evaluation of isotryptamine derivatives at 5-HT(2) serotonin receptors. Bioorg Med Chem Lett. 2002 Jan 21;12(2):155-8. DM3JGVF RU https://pubmed.ncbi.nlm.nih.gov/11755343 DM3JGVF DI DM3JGVF DM3JGVF DN 1,2,3,4-Tetrahydro-pyrazino[1,2-a]indole DM3JGVF MI TTWG9A4 DM3JGVF MN Adrenergic receptor alpha-2A (ADRA2A) DM3JGVF MT DTT DM3JGVF MA Inhibitor DM3JGVF RN Pyrazino[1,2-a]indoles as novel high-affinity and selective imidazoline I(2) receptor ligands. Bioorg Med Chem Lett. 2004 Feb 23;14(4):1003-5. DM3JGVF RU https://pubmed.ncbi.nlm.nih.gov/15013010 DM3JGVF DI DM3JGVF DM3JGVF DN 1,2,3,4-Tetrahydro-pyrazino[1,2-a]indole DM3JGVF MI TTWM4TY DM3JGVF MN Adrenergic receptor alpha-2B (ADRA2B) DM3JGVF MT DTT DM3JGVF MA Inhibitor DM3JGVF RN Pyrazino[1,2-a]indoles as novel high-affinity and selective imidazoline I(2) receptor ligands. Bioorg Med Chem Lett. 2004 Feb 23;14(4):1003-5. DM3JGVF RU https://pubmed.ncbi.nlm.nih.gov/15013010 DM3JGVF DI DM3JGVF DM3JGVF DN 1,2,3,4-Tetrahydro-pyrazino[1,2-a]indole DM3JGVF MI TT2NUT5 DM3JGVF MN Adrenergic receptor alpha-2C (ADRA2C) DM3JGVF MT DTT DM3JGVF MA Inhibitor DM3JGVF RN Pyrazino[1,2-a]indoles as novel high-affinity and selective imidazoline I(2) receptor ligands. Bioorg Med Chem Lett. 2004 Feb 23;14(4):1003-5. DM3JGVF RU https://pubmed.ncbi.nlm.nih.gov/15013010 DM3JGVF DI DM3JGVF DM3JGVF DN 1,2,3,4-Tetrahydro-pyrazino[1,2-a]indole DM3JGVF MI TT3WG5C DM3JGVF MN Monoamine oxidase type A (MAO-A) DM3JGVF MT DTT DM3JGVF MA Inhibitor DM3JGVF RN Pyrazino[1,2-a]indoles as novel high-affinity and selective imidazoline I(2) receptor ligands. Bioorg Med Chem Lett. 2004 Feb 23;14(4):1003-5. DM3JGVF RU https://pubmed.ncbi.nlm.nih.gov/15013010 DM3JGVF DI DM3JGVF DM3JGVF DN 1,2,3,4-Tetrahydro-pyrazino[1,2-a]indole DM3JGVF MI TTGP7BY DM3JGVF MN Monoamine oxidase type B (MAO-B) DM3JGVF MT DTT DM3JGVF MA Inhibitor DM3JGVF RN Pyrazino[1,2-a]indoles as novel high-affinity and selective imidazoline I(2) receptor ligands. Bioorg Med Chem Lett. 2004 Feb 23;14(4):1003-5. DM3JGVF RU https://pubmed.ncbi.nlm.nih.gov/15013010 DMFDK4N DI DMFDK4N DMFDK4N DN 1',2',3',6'-Tetrahydro-[2,4']bipyridinyl DMFDK4N MI TTNGILX DMFDK4N MN Adrenergic receptor alpha-1A (ADRA1A) DMFDK4N MT DTT DMFDK4N MA Inhibitor DMFDK4N RN Adrenoceptor and tetrabenazine antagonism activities of some pyridinyltetrahydropyridines. J Med Chem. 1984 Sep;27(9):1182-5. DMFDK4N RU https://pubmed.ncbi.nlm.nih.gov/6088770 DMFDK4N DI DMFDK4N DMFDK4N DN 1',2',3',6'-Tetrahydro-[2,4']bipyridinyl DMFDK4N MI TT34BHT DMFDK4N MN Adrenergic receptor alpha-1D (ADRA1D) DMFDK4N MT DTT DMFDK4N MA Inhibitor DMFDK4N RN Adrenoceptor and tetrabenazine antagonism activities of some pyridinyltetrahydropyridines. J Med Chem. 1984 Sep;27(9):1182-5. DMFDK4N RU https://pubmed.ncbi.nlm.nih.gov/6088770 DMFDK4N DI DMFDK4N DMFDK4N DN 1',2',3',6'-Tetrahydro-[2,4']bipyridinyl DMFDK4N MI TTWG9A4 DMFDK4N MN Adrenergic receptor alpha-2A (ADRA2A) DMFDK4N MT DTT DMFDK4N MA Inhibitor DMFDK4N RN Adrenoceptor and tetrabenazine antagonism activities of some pyridinyltetrahydropyridines. J Med Chem. 1984 Sep;27(9):1182-5. DMFDK4N RU https://pubmed.ncbi.nlm.nih.gov/6088770 DMFDK4N DI DMFDK4N DMFDK4N DN 1',2',3',6'-Tetrahydro-[2,4']bipyridinyl DMFDK4N MI TTWM4TY DMFDK4N MN Adrenergic receptor alpha-2B (ADRA2B) DMFDK4N MT DTT DMFDK4N MA Inhibitor DMFDK4N RN Adrenoceptor and tetrabenazine antagonism activities of some pyridinyltetrahydropyridines. J Med Chem. 1984 Sep;27(9):1182-5. DMFDK4N RU https://pubmed.ncbi.nlm.nih.gov/6088770 DMYDGAZ DI DMYDGAZ DMYDGAZ DN 1,2,3,7,12,12a-hexahydro-1-aza-pleiaden-5-ol DMYDGAZ MI TTZFYLI DMYDGAZ MN Dopamine D1 receptor (D1R) DMYDGAZ MT DTT DMYDGAZ MA Inhibitor DMYDGAZ RN Advances in development of dopaminergic aporphinoids. J Med Chem. 2007 Jan 25;50(2):171-81. DMYDGAZ RU https://pubmed.ncbi.nlm.nih.gov/17228858 DMAJ0B4 DI DMAJ0B4 DMAJ0B4 DN 1,2,3,7,12,12a-hexahydro-1-aza-pleiadene-5,6-diol DMAJ0B4 MI TTZFYLI DMAJ0B4 MN Dopamine D1 receptor (D1R) DMAJ0B4 MT DTT DMAJ0B4 MA Inhibitor DMAJ0B4 RN Advances in development of dopaminergic aporphinoids. J Med Chem. 2007 Jan 25;50(2):171-81. DMAJ0B4 RU https://pubmed.ncbi.nlm.nih.gov/17228858 DMAJ0B4 DI DMAJ0B4 DMAJ0B4 DN 1,2,3,7,12,12a-hexahydro-1-aza-pleiadene-5,6-diol DMAJ0B4 MI TTEX248 DMAJ0B4 MN Dopamine D2 receptor (D2R) DMAJ0B4 MT DTT DMAJ0B4 MA Inhibitor DMAJ0B4 RN Advances in development of dopaminergic aporphinoids. J Med Chem. 2007 Jan 25;50(2):171-81. DMAJ0B4 RU https://pubmed.ncbi.nlm.nih.gov/17228858 DMXL5R7 DI DMXL5R7 DMXL5R7 DN 1,2,3-benzenetricarboxylic acid DMXL5R7 MI TTTD730 DMXL5R7 MN Mitochondrial citrate transporter (SLC25A1) DMXL5R7 MT DTT DMXL5R7 MA Inhibitor DMXL5R7 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1051). DMXL5R7 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1051 DM73F5A DI DM73F5A DM73F5A DN 1,2,4-Triazole DM73F5A MI TTANPDJ DM73F5A MN Carbonic anhydrase II (CA-II) DM73F5A MT DTT DM73F5A MA Inhibitor DM73F5A RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DM73F5A RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMOXLHT DI DMOXLHT DMOXLHT DN 1,2,4-Triazole-Carboxamidine DMOXLHT MI TTCM4B3 DMOXLHT MN Nitric-oxide synthase endothelial (NOS3) DMOXLHT MT DTT DMOXLHT MA Inhibitor DMOXLHT RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMOXLHT RU https://pubmed.ncbi.nlm.nih.gov/17139284 DM7BAU2 DI DM7BAU2 DM7BAU2 DN 1,2,5,6-tetrahydro pyrido[1,2-a]quinolin-3-one DM7BAU2 MI TTTU72V DM7BAU2 MN Steroid 5-alpha-reductase 1 (SRD5A1) DM7BAU2 MT DTT DM7BAU2 MA Inhibitor DM7BAU2 RN Benzo[c]quinolizin-3-ones: a novel class of potent and selective nonsteroidal inhibitors of human steroid 5alpha-reductase 1. J Med Chem. 2000 Oct 5;43(20):3718-35. DM7BAU2 RU https://pubmed.ncbi.nlm.nih.gov/11020287 DM9VYOI DI DM9VYOI DM9VYOI DN 1,2,5-THIADIAZOLIDIN-3-ONE-1,1-DIOXIDE DM9VYOI MI TTELIN2 DM9VYOI MN PTPN1 messenger RNA (PTPN1 mRNA) DM9VYOI MT DTT DM9VYOI MA Inhibitor DM9VYOI RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DM9VYOI RU https://pubmed.ncbi.nlm.nih.gov/10592235 DMWGN3F DI DMWGN3F DMWGN3F DN 1,2,6-tri-O-galloyl-beta-D-glucose DMWGN3F MI TTE14XG DMWGN3F MN Squalene monooxygenase (SQLE) DMWGN3F MT DTT DMWGN3F MA Inhibitor DMWGN3F RN Ellagitannins and hexahydroxydiphenoyl esters as inhibitors of vertebrate squalene epoxidase. J Nat Prod. 2001 Aug;64(8):1010-4. DMWGN3F RU https://pubmed.ncbi.nlm.nih.gov/11520216 DMZSL7H DI DMZSL7H DMZSL7H DN 1,2-bis(2,3,4-trifluorophenyl)-2-hydroxyethanone DMZSL7H MI TTMF541 DMZSL7H MN Liver carboxylesterase (CES1) DMZSL7H MT DTT DMZSL7H MA Inhibitor DMZSL7H RN Analysis of the inhibition of mammalian carboxylesterases by novel fluorobenzoins and fluorobenzils. Bioorg Med Chem. 2007 Jun 1;15(11):3801-17. DMZSL7H RU https://pubmed.ncbi.nlm.nih.gov/17399985 DML5ECR DI DML5ECR DML5ECR DN 1,2-bis(2,3,4-trifluorophenyl)ethane-1,2-dione DML5ECR MI TTMF541 DML5ECR MN Liver carboxylesterase (CES1) DML5ECR MT DTT DML5ECR MA Inhibitor DML5ECR RN Analysis of the inhibition of mammalian carboxylesterases by novel fluorobenzoins and fluorobenzils. Bioorg Med Chem. 2007 Jun 1;15(11):3801-17. DML5ECR RU https://pubmed.ncbi.nlm.nih.gov/17399985 DMD9HP8 DI DMD9HP8 DMD9HP8 DN 1,2-bis(2,3,5-trifluorophenyl)-2-hydroxyethanone DMD9HP8 MI TTMF541 DMD9HP8 MN Liver carboxylesterase (CES1) DMD9HP8 MT DTT DMD9HP8 MA Inhibitor DMD9HP8 RN Analysis of the inhibition of mammalian carboxylesterases by novel fluorobenzoins and fluorobenzils. Bioorg Med Chem. 2007 Jun 1;15(11):3801-17. DMD9HP8 RU https://pubmed.ncbi.nlm.nih.gov/17399985 DMZHWAV DI DMZHWAV DMZHWAV DN 1,2-bis(2,3,5-trifluorophenyl)ethane-1,2-dione DMZHWAV MI TTMF541 DMZHWAV MN Liver carboxylesterase (CES1) DMZHWAV MT DTT DMZHWAV MA Inhibitor DMZHWAV RN Analysis of the inhibition of mammalian carboxylesterases by novel fluorobenzoins and fluorobenzils. Bioorg Med Chem. 2007 Jun 1;15(11):3801-17. DMZHWAV RU https://pubmed.ncbi.nlm.nih.gov/17399985 DMWS2HL DI DMWS2HL DMWS2HL DN 1,2-bis(2,3,6-trifluorophenyl)ethane-1,2-dione DMWS2HL MI TTMF541 DMWS2HL MN Liver carboxylesterase (CES1) DMWS2HL MT DTT DMWS2HL MA Inhibitor DMWS2HL RN Analysis of the inhibition of mammalian carboxylesterases by novel fluorobenzoins and fluorobenzils. Bioorg Med Chem. 2007 Jun 1;15(11):3801-17. DMWS2HL RU https://pubmed.ncbi.nlm.nih.gov/17399985 DMZ0D5W DI DMZ0D5W DMZ0D5W DN 1,2-bis(2,3-difluorophenyl)-2-hydroxyethanone DMZ0D5W MI TTMF541 DMZ0D5W MN Liver carboxylesterase (CES1) DMZ0D5W MT DTT DMZ0D5W MA Inhibitor DMZ0D5W RN Analysis of the inhibition of mammalian carboxylesterases by novel fluorobenzoins and fluorobenzils. Bioorg Med Chem. 2007 Jun 1;15(11):3801-17. DMZ0D5W RU https://pubmed.ncbi.nlm.nih.gov/17399985 DM9Z1NY DI DM9Z1NY DM9Z1NY DN 1,2-bis(2,3-fluorophenyl)ethane-1,2-dione DM9Z1NY MI TTEB0GD DM9Z1NY MN Cholinesterase (BCHE) DM9Z1NY MT DTT DM9Z1NY MA Inhibitor DM9Z1NY RN Analysis of the inhibition of mammalian carboxylesterases by novel fluorobenzoins and fluorobenzils. Bioorg Med Chem. 2007 Jun 1;15(11):3801-17. DM9Z1NY RU https://pubmed.ncbi.nlm.nih.gov/17399985 DM9Z1NY DI DM9Z1NY DM9Z1NY DN 1,2-bis(2,3-fluorophenyl)ethane-1,2-dione DM9Z1NY MI TTMF541 DM9Z1NY MN Liver carboxylesterase (CES1) DM9Z1NY MT DTT DM9Z1NY MA Inhibitor DM9Z1NY RN Analysis of the inhibition of mammalian carboxylesterases by novel fluorobenzoins and fluorobenzils. Bioorg Med Chem. 2007 Jun 1;15(11):3801-17. DM9Z1NY RU https://pubmed.ncbi.nlm.nih.gov/17399985 DMLMCBW DI DMLMCBW DMLMCBW DN 1,2-bis(2,4-difluorophenyl)-2-hydroxyethanone DMLMCBW MI TTMF541 DMLMCBW MN Liver carboxylesterase (CES1) DMLMCBW MT DTT DMLMCBW MA Inhibitor DMLMCBW RN Analysis of the inhibition of mammalian carboxylesterases by novel fluorobenzoins and fluorobenzils. Bioorg Med Chem. 2007 Jun 1;15(11):3801-17. DMLMCBW RU https://pubmed.ncbi.nlm.nih.gov/17399985 DMUZHPS DI DMUZHPS DMUZHPS DN 1,2-bis(2,4-difluorophenyl)ethane-1,2-dione DMUZHPS MI TTMF541 DMUZHPS MN Liver carboxylesterase (CES1) DMUZHPS MT DTT DMUZHPS MA Inhibitor DMUZHPS RN Analysis of the inhibition of mammalian carboxylesterases by novel fluorobenzoins and fluorobenzils. Bioorg Med Chem. 2007 Jun 1;15(11):3801-17. DMUZHPS RU https://pubmed.ncbi.nlm.nih.gov/17399985 DM9EW2F DI DM9EW2F DM9EW2F DN 1,2-bis(2,5-difluorophenyl)-2-hydroxyethanone DM9EW2F MI TTMF541 DM9EW2F MN Liver carboxylesterase (CES1) DM9EW2F MT DTT DM9EW2F MA Inhibitor DM9EW2F RN Analysis of the inhibition of mammalian carboxylesterases by novel fluorobenzoins and fluorobenzils. Bioorg Med Chem. 2007 Jun 1;15(11):3801-17. DM9EW2F RU https://pubmed.ncbi.nlm.nih.gov/17399985 DMVLMBQ DI DMVLMBQ DMVLMBQ DN 1,2-bis(2,5-difluorophenyl)ethane-1,2-dione DMVLMBQ MI TTMF541 DMVLMBQ MN Liver carboxylesterase (CES1) DMVLMBQ MT DTT DMVLMBQ MA Inhibitor DMVLMBQ RN Analysis of the inhibition of mammalian carboxylesterases by novel fluorobenzoins and fluorobenzils. Bioorg Med Chem. 2007 Jun 1;15(11):3801-17. DMVLMBQ RU https://pubmed.ncbi.nlm.nih.gov/17399985 DMSMVCH DI DMSMVCH DMSMVCH DN 1,2-bis(2,6-difluorophenyl)-2-hydroxyethanone DMSMVCH MI TTMF541 DMSMVCH MN Liver carboxylesterase (CES1) DMSMVCH MT DTT DMSMVCH MA Inhibitor DMSMVCH RN Analysis of the inhibition of mammalian carboxylesterases by novel fluorobenzoins and fluorobenzils. Bioorg Med Chem. 2007 Jun 1;15(11):3801-17. DMSMVCH RU https://pubmed.ncbi.nlm.nih.gov/17399985 DM351EA DI DM351EA DM351EA DN 1,2-bis(2,6-difluorophenyl)ethane-1,2-dione DM351EA MI TTMF541 DM351EA MN Liver carboxylesterase (CES1) DM351EA MT DTT DM351EA MA Inhibitor DM351EA RN Analysis of the inhibition of mammalian carboxylesterases by novel fluorobenzoins and fluorobenzils. Bioorg Med Chem. 2007 Jun 1;15(11):3801-17. DM351EA RU https://pubmed.ncbi.nlm.nih.gov/17399985 DMZF4IC DI DMZF4IC DMZF4IC DN 1,2-Bis-(2-chloro-phenyl)-ethane-1,2-dione DMZF4IC MI TTMF541 DMZF4IC MN Liver carboxylesterase (CES1) DMZF4IC MT DTT DMZF4IC MA Inhibitor DMZF4IC RN Identification and characterization of novel benzil (diphenylethane-1,2-dione) analogues as inhibitors of mammalian carboxylesterases. J Med Chem. 2005 Apr 21;48(8):2906-15. DMZF4IC RU https://pubmed.ncbi.nlm.nih.gov/15828829 DMNWM5S DI DMNWM5S DMNWM5S DN 1,2-bis(2-fluorophenyl)-2-hydroxyethanone DMNWM5S MI TTMF541 DMNWM5S MN Liver carboxylesterase (CES1) DMNWM5S MT DTT DMNWM5S MA Inhibitor DMNWM5S RN Analysis of the inhibition of mammalian carboxylesterases by novel fluorobenzoins and fluorobenzils. Bioorg Med Chem. 2007 Jun 1;15(11):3801-17. DMNWM5S RU https://pubmed.ncbi.nlm.nih.gov/17399985 DM9FMUE DI DM9FMUE DM9FMUE DN 1,2-bis(2-fluorophenyl)ethane-1,2-dione DM9FMUE MI TTMF541 DM9FMUE MN Liver carboxylesterase (CES1) DM9FMUE MT DTT DM9FMUE MA Inhibitor DM9FMUE RN Analysis of the inhibition of mammalian carboxylesterases by novel fluorobenzoins and fluorobenzils. Bioorg Med Chem. 2007 Jun 1;15(11):3801-17. DM9FMUE RU https://pubmed.ncbi.nlm.nih.gov/17399985 DM0LWAV DI DM0LWAV DM0LWAV DN 1,2-bis(3,4,5-trifluorophenyl)-2-hydroxyethanone DM0LWAV MI TTMF541 DM0LWAV MN Liver carboxylesterase (CES1) DM0LWAV MT DTT DM0LWAV MA Inhibitor DM0LWAV RN Analysis of the inhibition of mammalian carboxylesterases by novel fluorobenzoins and fluorobenzils. Bioorg Med Chem. 2007 Jun 1;15(11):3801-17. DM0LWAV RU https://pubmed.ncbi.nlm.nih.gov/17399985 DMPJT3V DI DMPJT3V DMPJT3V DN 1,2-bis(3,4,5-trifluorophenyl)ethane-1,2-dione DMPJT3V MI TTMF541 DMPJT3V MN Liver carboxylesterase (CES1) DMPJT3V MT DTT DMPJT3V MA Inhibitor DMPJT3V RN Analysis of the inhibition of mammalian carboxylesterases by novel fluorobenzoins and fluorobenzils. Bioorg Med Chem. 2007 Jun 1;15(11):3801-17. DMPJT3V RU https://pubmed.ncbi.nlm.nih.gov/17399985 DMRCUKJ DI DMRCUKJ DMRCUKJ DN 1,2-bis(3,4-difluorophenyl)-2-hydroxyethanone DMRCUKJ MI TTMF541 DMRCUKJ MN Liver carboxylesterase (CES1) DMRCUKJ MT DTT DMRCUKJ MA Inhibitor DMRCUKJ RN Analysis of the inhibition of mammalian carboxylesterases by novel fluorobenzoins and fluorobenzils. Bioorg Med Chem. 2007 Jun 1;15(11):3801-17. DMRCUKJ RU https://pubmed.ncbi.nlm.nih.gov/17399985 DMBZ5RN DI DMBZ5RN DMBZ5RN DN 1,2-bis(3,4-difluorophenyl)ethane-1,2-dione DMBZ5RN MI TTMF541 DMBZ5RN MN Liver carboxylesterase (CES1) DMBZ5RN MT DTT DMBZ5RN MA Inhibitor DMBZ5RN RN Analysis of the inhibition of mammalian carboxylesterases by novel fluorobenzoins and fluorobenzils. Bioorg Med Chem. 2007 Jun 1;15(11):3801-17. DMBZ5RN RU https://pubmed.ncbi.nlm.nih.gov/17399985 DMQTPX2 DI DMQTPX2 DMQTPX2 DN 1,2-bis(3,5-difluorophenyl)-2-hydroxyethanone DMQTPX2 MI TTMF541 DMQTPX2 MN Liver carboxylesterase (CES1) DMQTPX2 MT DTT DMQTPX2 MA Inhibitor DMQTPX2 RN Analysis of the inhibition of mammalian carboxylesterases by novel fluorobenzoins and fluorobenzils. Bioorg Med Chem. 2007 Jun 1;15(11):3801-17. DMQTPX2 RU https://pubmed.ncbi.nlm.nih.gov/17399985 DM3K5RI DI DM3K5RI DM3K5RI DN 1,2-bis(3,5-difluorophenyl)ethane-1,2-dione DM3K5RI MI TTMF541 DM3K5RI MN Liver carboxylesterase (CES1) DM3K5RI MT DTT DM3K5RI MA Inhibitor DM3K5RI RN Analysis of the inhibition of mammalian carboxylesterases by novel fluorobenzoins and fluorobenzils. Bioorg Med Chem. 2007 Jun 1;15(11):3801-17. DM3K5RI RU https://pubmed.ncbi.nlm.nih.gov/17399985 DM8XGD0 DI DM8XGD0 DM8XGD0 DN 1,2-bis(3-fluorophenyl)-2-hydroxyethanon DM8XGD0 MI TTMF541 DM8XGD0 MN Liver carboxylesterase (CES1) DM8XGD0 MT DTT DM8XGD0 MA Inhibitor DM8XGD0 RN Analysis of the inhibition of mammalian carboxylesterases by novel fluorobenzoins and fluorobenzils. Bioorg Med Chem. 2007 Jun 1;15(11):3801-17. DM8XGD0 RU https://pubmed.ncbi.nlm.nih.gov/17399985 DMM3I1P DI DMM3I1P DMM3I1P DN 1,2-bis(3-fluorophenyl)ethane-1,2-dione DMM3I1P MI TTMF541 DMM3I1P MN Liver carboxylesterase (CES1) DMM3I1P MT DTT DMM3I1P MA Inhibitor DMM3I1P RN Analysis of the inhibition of mammalian carboxylesterases by novel fluorobenzoins and fluorobenzils. Bioorg Med Chem. 2007 Jun 1;15(11):3801-17. DMM3I1P RU https://pubmed.ncbi.nlm.nih.gov/17399985 DMWY1QN DI DMWY1QN DMWY1QN DN 1,2-Bis-(3-methoxy-phenyl)-ethane-1,2-dione DMWY1QN MI TTMF541 DMWY1QN MN Liver carboxylesterase (CES1) DMWY1QN MT DTT DMWY1QN MA Inhibitor DMWY1QN RN Identification and characterization of novel benzil (diphenylethane-1,2-dione) analogues as inhibitors of mammalian carboxylesterases. J Med Chem. 2005 Apr 21;48(8):2906-15. DMWY1QN RU https://pubmed.ncbi.nlm.nih.gov/15828829 DMGSTKZ DI DMGSTKZ DMGSTKZ DN 1,2-Bis-(3-nitro-phenyl)-ethane-1,2-dione DMGSTKZ MI TTMF541 DMGSTKZ MN Liver carboxylesterase (CES1) DMGSTKZ MT DTT DMGSTKZ MA Inhibitor DMGSTKZ RN Identification and characterization of novel benzil (diphenylethane-1,2-dione) analogues as inhibitors of mammalian carboxylesterases. J Med Chem. 2005 Apr 21;48(8):2906-15. DMGSTKZ RU https://pubmed.ncbi.nlm.nih.gov/15828829 DMUW2EJ DI DMUW2EJ DMUW2EJ DN 1,2-Bis-(4-bromo-phenyl)-ethane-1,2-dione DMUW2EJ MI TTMF541 DMUW2EJ MN Liver carboxylesterase (CES1) DMUW2EJ MT DTT DMUW2EJ MA Inhibitor DMUW2EJ RN Identification and characterization of novel benzil (diphenylethane-1,2-dione) analogues as inhibitors of mammalian carboxylesterases. J Med Chem. 2005 Apr 21;48(8):2906-15. DMUW2EJ RU https://pubmed.ncbi.nlm.nih.gov/15828829 DM0E5FH DI DM0E5FH DM0E5FH DN 1,2-Bis-(4-chloro-phenyl)-ethane-1,2-dione DM0E5FH MI TTMF541 DM0E5FH MN Liver carboxylesterase (CES1) DM0E5FH MT DTT DM0E5FH MA Inhibitor DM0E5FH RN Identification and characterization of novel benzil (diphenylethane-1,2-dione) analogues as inhibitors of mammalian carboxylesterases. J Med Chem. 2005 Apr 21;48(8):2906-15. DM0E5FH RU https://pubmed.ncbi.nlm.nih.gov/15828829 DM38Q7W DI DM38Q7W DM38Q7W DN 1,2-bis(4-fluorophenyl)ethane-1,2-dione DM38Q7W MI TTMF541 DM38Q7W MN Liver carboxylesterase (CES1) DM38Q7W MT DTT DM38Q7W MA Inhibitor DM38Q7W RN Analysis of the inhibition of mammalian carboxylesterases by novel fluorobenzoins and fluorobenzils. Bioorg Med Chem. 2007 Jun 1;15(11):3801-17. DM38Q7W RU https://pubmed.ncbi.nlm.nih.gov/17399985 DM9RF1T DI DM9RF1T DM9RF1T DN 1,2-Bis-(4-hydroxy-phenyl)-3H-inden-5-ol DM9RF1T MI TTZAYWL DM9RF1T MN Estrogen receptor (ESR) DM9RF1T MT DTT DM9RF1T MA Inhibitor DM9RF1T RN Differential response of estrogen receptor subtypes to 1,3-diarylindene and 2,3-diarylindene ligands. J Med Chem. 2005 Sep 22;48(19):5989-6003. DM9RF1T RU https://pubmed.ncbi.nlm.nih.gov/16162002 DM9RF1T DI DM9RF1T DM9RF1T DN 1,2-Bis-(4-hydroxy-phenyl)-3H-inden-5-ol DM9RF1T MI TTOM3J0 DM9RF1T MN Estrogen receptor beta (ESR2) DM9RF1T MT DTT DM9RF1T MA Inhibitor DM9RF1T RN Differential response of estrogen receptor subtypes to 1,3-diarylindene and 2,3-diarylindene ligands. J Med Chem. 2005 Sep 22;48(19):5989-6003. DM9RF1T RU https://pubmed.ncbi.nlm.nih.gov/16162002 DMCGRV7 DI DMCGRV7 DMCGRV7 DN 1,2-Bis-(4-methoxy-phenyl)-ethane-1,2-dione DMCGRV7 MI TTMF541 DMCGRV7 MN Liver carboxylesterase (CES1) DMCGRV7 MT DTT DMCGRV7 MA Inhibitor DMCGRV7 RN Identification and characterization of novel benzil (diphenylethane-1,2-dione) analogues as inhibitors of mammalian carboxylesterases. J Med Chem. 2005 Apr 21;48(8):2906-15. DMCGRV7 RU https://pubmed.ncbi.nlm.nih.gov/15828829 DM9ENXO DI DM9ENXO DM9ENXO DN 1,2-Bis-[R-(-)-apomorphine-2'-oxy]ethane DM9ENXO MI TTZFYLI DM9ENXO MN Dopamine D1 receptor (D1R) DM9ENXO MT DTT DM9ENXO MA Inhibitor DM9ENXO RN Synthesis and neuropharmacological characterization of 2-O-substituted apomorphines. Bioorg Med Chem. 2008 Apr 15;16(8):4563-8. DM9ENXO RU https://pubmed.ncbi.nlm.nih.gov/18313931 DM9ENXO DI DM9ENXO DM9ENXO DN 1,2-Bis-[R-(-)-apomorphine-2'-oxy]ethane DM9ENXO MI TTEX248 DM9ENXO MN Dopamine D2 receptor (D2R) DM9ENXO MT DTT DM9ENXO MA Inhibitor DM9ENXO RN Synthesis and neuropharmacological characterization of 2-O-substituted apomorphines. Bioorg Med Chem. 2008 Apr 15;16(8):4563-8. DM9ENXO RU https://pubmed.ncbi.nlm.nih.gov/18313931 DMJAK0E DI DMJAK0E DMJAK0E DN 1,2-di(10H-phenothiazin-10-yl)ethane-1,2-dione DMJAK0E MI TTEB0GD DMJAK0E MN Cholinesterase (BCHE) DMJAK0E MT DTT DMJAK0E MA Inhibitor DMJAK0E RN Selective reversible inhibition of human butyrylcholinesterase by aryl amide derivatives of phenothiazine. Bioorg Med Chem. 2007 Oct 1;15(19):6367-78. DMJAK0E RU https://pubmed.ncbi.nlm.nih.gov/17681768 DM7S1D5 DI DM7S1D5 DM7S1D5 DN 1,2-Di(berberine-9-O-yl)ethane dibromide DM7S1D5 MI TT1RS9F DM7S1D5 MN Acetylcholinesterase (AChE) DM7S1D5 MT DTT DM7S1D5 MA Inhibitor DM7S1D5 RN Synthesis and biological evaluation of a new series of berberine derivatives as dual inhibitors of acetylcholinesterase and butyrylcholinesterase. Bioorg Med Chem. 2010 Jun 15;18(12):4475-84. DM7S1D5 RU https://pubmed.ncbi.nlm.nih.gov/20471843 DM7S1D5 DI DM7S1D5 DM7S1D5 DN 1,2-Di(berberine-9-O-yl)ethane dibromide DM7S1D5 MI TTEB0GD DM7S1D5 MN Cholinesterase (BCHE) DM7S1D5 MT DTT DM7S1D5 MA Inhibitor DM7S1D5 RN Synthesis and biological evaluation of a new series of berberine derivatives as dual inhibitors of acetylcholinesterase and butyrylcholinesterase. Bioorg Med Chem. 2010 Jun 15;18(12):4475-84. DM7S1D5 RU https://pubmed.ncbi.nlm.nih.gov/20471843 DMBAX2L DI DMBAX2L DMBAX2L DN 1,2-Diacetoxylycorine DMBAX2L MI TTXV4FI DMBAX2L MN Albendazole monooxygenase (CYP3A4) DMBAX2L MT DTT DMBAX2L MA Inhibitor DMBAX2L RN Selective cytochrome P450 3A4 inhibitory activity of Amaryllidaceae alkaloids. Bioorg Med Chem Lett. 2009 Jun 15;19(12):3233-7. DMBAX2L RU https://pubmed.ncbi.nlm.nih.gov/19428250 DMDJYHK DI DMDJYHK DMDJYHK DN 1,2-dibromo-4-(1,2-dibromoethyl)cyclohexane DMDJYHK MI TTS64P2 DMDJYHK MN Androgen receptor (AR) DMDJYHK MT DTT DMDJYHK MA Inhibitor DMDJYHK RN Identification of the brominated flame retardant 1,2-dibromo-4-(1,2-dibromoethyl)cyclohexane as an androgen agonist. J Med Chem. 2006 Dec 14;49(25):7366-72. DMDJYHK RU https://pubmed.ncbi.nlm.nih.gov/17149866 DMDJYHK DI DMDJYHK DMDJYHK DN 1,2-dibromo-4-(1,2-dibromoethyl)cyclohexane DMDJYHK MI TTKPW01 DMDJYHK MN Androgen receptor messenger RNA (AR mRNA) DMDJYHK MT DTT DMDJYHK MA Inhibitor DMDJYHK RN Identification of the brominated flame retardant 1,2-dibromo-4-(1,2-dibromoethyl)cyclohexane as an androgen agonist. J Med Chem. 2006 Dec 14;49(25):7366-72. DMDJYHK RU https://pubmed.ncbi.nlm.nih.gov/17149866 DM75OR8 DI DM75OR8 DM75OR8 DN 1,2-dicyclohexylethane-1,2-dione DM75OR8 MI TTMF541 DM75OR8 MN Liver carboxylesterase (CES1) DM75OR8 MT DTT DM75OR8 MA Inhibitor DM75OR8 RN Planarity and constraint of the carbonyl groups in 1,2-diones are determinants for selective inhibition of human carboxylesterase 1. J Med Chem. 2007 Nov 15;50(23):5727-34. DM75OR8 RU https://pubmed.ncbi.nlm.nih.gov/17941623 DM542I9 DI DM542I9 DM542I9 DN 1,2-dihydro-2-oxoquinazoline-4-carboxyanilide DM542I9 MI TTJFY5U DM542I9 MN Adenosine A3 receptor (ADORA3) DM542I9 MT DTT DM542I9 MA Inhibitor DM542I9 RN Scouting human A3 adenosine receptor antagonist binding mode using a molecular simplification approach: from triazoloquinoxaline to a pyrimidine sk... J Med Chem. 2007 Dec 27;50(26):6596-606. DM542I9 RU https://pubmed.ncbi.nlm.nih.gov/18047262 DMST60D DI DMST60D DMST60D DN 1,2-dihydro-3-(2,3,4-trimethoxyphenyl)naphthalene DMST60D MI TT8NGED DMST60D MN Prostaglandin G/H synthase 1 (COX-1) DMST60D MT DTT DMST60D MA Inhibitor DMST60D RN 'Bridged' stilbene derivatives as selective cyclooxygenase-1 inhibitors. Bioorg Med Chem. 2007 Sep 15;15(18):6109-18. DMST60D RU https://pubmed.ncbi.nlm.nih.gov/17604631 DMST60D DI DMST60D DMST60D DN 1,2-dihydro-3-(2,3,4-trimethoxyphenyl)naphthalene DMST60D MI TTVKILB DMST60D MN Prostaglandin G/H synthase 2 (COX-2) DMST60D MT DTT DMST60D MA Inhibitor DMST60D RN 'Bridged' stilbene derivatives as selective cyclooxygenase-1 inhibitors. Bioorg Med Chem. 2007 Sep 15;15(18):6109-18. DMST60D RU https://pubmed.ncbi.nlm.nih.gov/17604631 DM9G7DT DI DM9G7DT DM9G7DT DN 1,2-Dihydro-indazol-3-one DM9G7DT MI TT2J34L DM9G7DT MN Arachidonate 5-lipoxygenase (5-LOX) DM9G7DT MT DTT DM9G7DT MA Inhibitor DM9G7DT RN Indazolinones, a new series of redox-active 5-lipoxygenase inhibitors with built-in selectivity and oral activity. J Med Chem. 1991 Mar;34(3):1028-36. DM9G7DT RU https://pubmed.ncbi.nlm.nih.gov/1848292 DMASC8K DI DMASC8K DMASC8K DN 1,2-Dihydroxy-10H-anthracen-9-one DMASC8K MI TT2J34L DMASC8K MN Arachidonate 5-lipoxygenase (5-LOX) DMASC8K MT DTT DMASC8K MA Inhibitor DMASC8K RN Simple analogues of anthralin: unusual specificity of structure and antiproliferative activity. J Med Chem. 1997 Nov 7;40(23):3773-80. DMASC8K RU https://pubmed.ncbi.nlm.nih.gov/9371243 DMGXMF0 DI DMGXMF0 DMGXMF0 DN 1,2-Di-naphthalen-2-yl-ethane-1,2-dione DMGXMF0 MI TTMF541 DMGXMF0 MN Liver carboxylesterase (CES1) DMGXMF0 MT DTT DMGXMF0 MA Inhibitor DMGXMF0 RN Inhibition of carboxylesterases by benzil (diphenylethane-1,2-dione) and heterocyclic analogues is dependent upon the aromaticity of the ring and t... J Med Chem. 2005 Aug 25;48(17):5543-50. DMGXMF0 RU https://pubmed.ncbi.nlm.nih.gov/16107154 DMEAB03 DI DMEAB03 DMEAB03 DN 1,2-dioctanoyl-sn-glycerol DMEAB03 MI TTFJ8Q1 DMEAB03 MN Protein kinase C alpha (PRKCA) DMEAB03 MT DTT DMEAB03 MA Inhibitor DMEAB03 RN Design, synthesis, and biological activity of isophthalic acid derivatives targeted to the C1 domain of protein kinase C. J Med Chem. 2009 Jul 9;52(13):3969-81. DMEAB03 RU https://pubmed.ncbi.nlm.nih.gov/19438240 DMFXB21 DI DMFXB21 DMFXB21 DN 1,2-Di-p-tolyl-ethane-1,2-dione DMFXB21 MI TTMF541 DMFXB21 MN Liver carboxylesterase (CES1) DMFXB21 MT DTT DMFXB21 MA Inhibitor DMFXB21 RN Identification and characterization of novel benzil (diphenylethane-1,2-dione) analogues as inhibitors of mammalian carboxylesterases. J Med Chem. 2005 Apr 21;48(8):2906-15. DMFXB21 RU https://pubmed.ncbi.nlm.nih.gov/15828829 DMV275G DI DMV275G DMV275G DN 1,2-indanedione DMV275G MI TTEB0GD DMV275G MN Cholinesterase (BCHE) DMV275G MT DTT DMV275G MA Inhibitor DMV275G RN Planarity and constraint of the carbonyl groups in 1,2-diones are determinants for selective inhibition of human carboxylesterase 1. J Med Chem. 2007 Nov 15;50(23):5727-34. DMV275G RU https://pubmed.ncbi.nlm.nih.gov/17941623 DMV275G DI DMV275G DMV275G DN 1,2-indanedione DMV275G MI TTMF541 DMV275G MN Liver carboxylesterase (CES1) DMV275G MT DTT DMV275G MA Inhibitor DMV275G RN Planarity and constraint of the carbonyl groups in 1,2-diones are determinants for selective inhibition of human carboxylesterase 1. J Med Chem. 2007 Nov 15;50(23):5727-34. DMV275G RU https://pubmed.ncbi.nlm.nih.gov/17941623 DMYXELH DI DMYXELH DMYXELH DN 1,2-NAPHTHOQUINONE DMYXELH MI TT1RS9F DMYXELH MN Acetylcholinesterase (AChE) DMYXELH MT DTT DMYXELH MA Inhibitor DMYXELH RN Planarity and constraint of the carbonyl groups in 1,2-diones are determinants for selective inhibition of human carboxylesterase 1. J Med Chem. 2007 Nov 15;50(23):5727-34. DMYXELH RU https://pubmed.ncbi.nlm.nih.gov/17941623 DMYXELH DI DMYXELH DMYXELH DN 1,2-NAPHTHOQUINONE DMYXELH MI TTEB0GD DMYXELH MN Cholinesterase (BCHE) DMYXELH MT DTT DMYXELH MA Inhibitor DMYXELH RN Planarity and constraint of the carbonyl groups in 1,2-diones are determinants for selective inhibition of human carboxylesterase 1. J Med Chem. 2007 Nov 15;50(23):5727-34. DMYXELH RU https://pubmed.ncbi.nlm.nih.gov/17941623 DMYXELH DI DMYXELH DMYXELH DN 1,2-NAPHTHOQUINONE DMYXELH MI DE3FEV8 DMYXELH MN Dicarbonyl/L-xylulose reductase (DCXR) DMYXELH MT DME DMYXELH MA Metabolism DMYXELH RN Diacetyl/l-xylulose reductase mediates chemical redox cycling in lung epithelial cells. Chem Res Toxicol. 2017 Jul 17;30(7):1406-1418. DMYXELH RU https://www.ncbi.nlm.nih.gov/pubmed/?term=28595002 DMYXELH DI DMYXELH DMYXELH DN 1,2-NAPHTHOQUINONE DMYXELH MI TTZJYKH DMYXELH MN Indoleamine 2,3-dioxygenase 1 (IDO1) DMYXELH MT DTT DMYXELH MA Inhibitor DMYXELH RN Indoleamine 2,3-dioxygenase is the anticancer target for a novel series of potent naphthoquinone-based inhibitors. J Med Chem. 2008 Mar 27;51(6):1706-18. DMYXELH RU https://pubmed.ncbi.nlm.nih.gov/18318466 DMYXELH DI DMYXELH DMYXELH DN 1,2-NAPHTHOQUINONE DMYXELH MI TTMF541 DMYXELH MN Liver carboxylesterase (CES1) DMYXELH MT DTT DMYXELH MA Inhibitor DMYXELH RN Planarity and constraint of the carbonyl groups in 1,2-diones are determinants for selective inhibition of human carboxylesterase 1. J Med Chem. 2007 Nov 15;50(23):5727-34. DMYXELH RU https://pubmed.ncbi.nlm.nih.gov/17941623 DMYXELH DI DMYXELH DMYXELH DN 1,2-NAPHTHOQUINONE DMYXELH MI DE8RYV5 DMYXELH MN NADPH:quinone reductase (CRYZ) DMYXELH MT DME DMYXELH MA Metabolism DMYXELH RN Effect of superoxide dismutase on the autoxidation of various hydroquinones--a possible role of superoxide dismutase as a superoxide:semiquinone oxidoreductase. Free Radic Biol Med. 1988;5(2):71-9. DMYXELH RU https://www.ncbi.nlm.nih.gov/pubmed/?term=2855420 DMYXELH DI DMYXELH DMYXELH DN 1,2-NAPHTHOQUINONE DMYXELH MI TTELIN2 DMYXELH MN PTPN1 messenger RNA (PTPN1 mRNA) DMYXELH MT DTT DMYXELH MA Inhibitor DMYXELH RN Synthesis and PTP1B inhibition of 1,2-naphthoquinone derivatives as potent anti-diabetic agents. Bioorg Med Chem Lett. 2002 Aug 5;12(15):1941-6. DMYXELH RU https://pubmed.ncbi.nlm.nih.gov/12113814 DMYXELH DI DMYXELH DMYXELH DN 1,2-NAPHTHOQUINONE DMYXELH MI DEJVDAT DMYXELH MN Sepiapterin reductase (SPR) DMYXELH MT DME DMYXELH MA Metabolism DMYXELH RN Sepiapterin reductase mediates chemical redox cycling in lung epithelial cells. J Biol Chem. 2013 Jun 28;288(26):19221-37. DMYXELH RU https://www.ncbi.nlm.nih.gov/pubmed/?term=23640889 DMNCWXZ DI DMNCWXZ DMNCWXZ DN 1,3,5-BENZENETRICARBOXYLIC ACID DMNCWXZ MI TTQO71U DMNCWXZ MN Hemoglobin (HB) DMNCWXZ MT DTT DMNCWXZ MA Inhibitor DMNCWXZ RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DMNCWXZ RU https://pubmed.ncbi.nlm.nih.gov/10592235 DM7U6S0 DI DM7U6S0 DM7U6S0 DN 1,3,5-triphenylimidazolidine-2,4-dione DM7U6S0 MI TT6OEDT DM7U6S0 MN Cannabinoid receptor 1 (CB1) DM7U6S0 MT DTT DM7U6S0 MA Inhibitor DM7U6S0 RN Synthesis and activity of 1,3,5-triphenylimidazolidine-2,4-diones and 1,3,5-triphenyl-2-thioxoimidazolidin-4-ones: characterization of new CB1 cann... J Med Chem. 2006 Feb 9;49(3):872-82. DM7U6S0 RU https://pubmed.ncbi.nlm.nih.gov/16451053 DMDNM05 DI DMDNM05 DMDNM05 DN 1,3,5-tris(4-chlorophenyl)imidazolidine-2,4-dione DMDNM05 MI TT6OEDT DMDNM05 MN Cannabinoid receptor 1 (CB1) DMDNM05 MT DTT DMDNM05 MA Inhibitor DMDNM05 RN Synthesis and activity of 1,3,5-triphenylimidazolidine-2,4-diones and 1,3,5-triphenyl-2-thioxoimidazolidin-4-ones: characterization of new CB1 cann... J Med Chem. 2006 Feb 9;49(3):872-82. DMDNM05 RU https://pubmed.ncbi.nlm.nih.gov/16451053 DMFA8CW DI DMFA8CW DMFA8CW DN 1,3,7-trihydroxyacridone DMFA8CW MI TT0IHXV DMFA8CW MN DNA topoisomerase II (TOP2) DMFA8CW MT DTT DMFA8CW MA Inhibitor DMFA8CW RN 1,3-Dihydroxyacridone derivatives as inhibitors of herpes virus replication. Antiviral Res. 2000 Feb;45(2):123-34. DMFA8CW RU https://pubmed.ncbi.nlm.nih.gov/10809021 DMNCJ5R DI DMNCJ5R DMNCJ5R DN 1,3,7-Tripropyl-3,7-dihydro-purine-2,6-dione DMNCJ5R MI TTM2AOE DMNCJ5R MN Adenosine A2a receptor (ADORA2A) DMNCJ5R MT DTT DMNCJ5R MA Inhibitor DMNCJ5R RN Analogues of caffeine and theophylline: effect of structural alterations on affinity at adenosine receptors. J Med Chem. 1986 Jul;29(7):1305-8. DMNCJ5R RU https://pubmed.ncbi.nlm.nih.gov/3806581 DMRP03X DI DMRP03X DMRP03X DN 1,3,8-Trihydroxy-6-methyl-10H-anthracen-9-one DMRP03X MI TT2J34L DMRP03X MN Arachidonate 5-lipoxygenase (5-LOX) DMRP03X MT DTT DMRP03X MA Inhibitor DMRP03X RN Simple analogues of anthralin: unusual specificity of structure and antiproliferative activity. J Med Chem. 1997 Nov 7;40(23):3773-80. DMRP03X RU https://pubmed.ncbi.nlm.nih.gov/9371243 DMOZEKU DI DMOZEKU DMOZEKU DN 1,3,8-Trimethyl-3,7-dihydro-purine-2,6-dione DMOZEKU MI TTM2AOE DMOZEKU MN Adenosine A2a receptor (ADORA2A) DMOZEKU MT DTT DMOZEKU MA Inhibitor DMOZEKU RN 1,3-Dialkyl-8-(p-sulfophenyl)xanthines: potent water-soluble antagonists for A1- and A2-adenosine receptors. J Med Chem. 1985 Apr;28(4):487-92. DMOZEKU RU https://pubmed.ncbi.nlm.nih.gov/2984420 DM7U31Q DI DM7U31Q DM7U31Q DN 1,3,9,9a-Tetrahydro-imidazo[4,5-b]quinolin-2-one DM7U31Q MI TT06AWU DM7U31Q MN Phosphodiesterase 3A (PDE3A) DM7U31Q MT DTT DM7U31Q MA Inhibitor DM7U31Q RN 1,3-Dihydro-2H-imidazo[4,5-b]quinolin-2-ones--inhibitors of blood platelet cAMP phosphodiesterase and induced aggregation. J Med Chem. 1991 Sep;34(9):2906-16. DM7U31Q RU https://pubmed.ncbi.nlm.nih.gov/1654430 DMP86R3 DI DMP86R3 DMP86R3 DN 1,3-bis(1,3-benzothiazol-2-ylthio)acetone DMP86R3 MI TTHGL48 DMP86R3 MN AP endonuclease 1 (APEX1) DMP86R3 MT DTT DMP86R3 MA Inhibitor DMP86R3 RN Development and evaluation of human AP endonuclease inhibitors in melanoma and glioma cell lines. Br J Cancer. 2011 Feb 15;104(4):653-63. DMP86R3 RU https://pubmed.ncbi.nlm.nih.gov/21266972 DMELSV1 DI DMELSV1 DMELSV1 DN 1,3-bis(3,4-dihydroxyphenyl)prop-2-en-1-one DMELSV1 MI TTQY2EJ DMELSV1 MN TERT messenger RNA (TERT mRNA) DMELSV1 MT DTT DMELSV1 MA Inhibitor DMELSV1 RN Catecholic flavonoids acting as telomerase inhibitors. J Med Chem. 2004 Dec 16;47(26):6466-75. DMELSV1 RU https://pubmed.ncbi.nlm.nih.gov/15588081 DM78UPQ DI DM78UPQ DM78UPQ DN 1,3-Bis-(3-imidazolidin-2-yl-phenyl)-urea DM78UPQ MI TT1RS9F DM78UPQ MN Acetylcholinesterase (AChE) DM78UPQ MT DTT DM78UPQ MA Inhibitor DM78UPQ RN Efficient method for high-throughput virtual screening based on flexible docking: discovery of novel acetylcholinesterase inhibitors. J Med Chem. 2004 Sep 23;47(20):4818-28. DM78UPQ RU https://pubmed.ncbi.nlm.nih.gov/15369385 DMIK7XV DI DMIK7XV DMIK7XV DN 1,3-bis(nitrooxy)propan-2-yl 2-acetoxybenzoate DMIK7XV MI TTVKILB DMIK7XV MN Prostaglandin G/H synthase 2 (COX-2) DMIK7XV MT DTT DMIK7XV MA Inhibitor DMIK7XV RN Dinitroglyceryl and diazen-1-ium-1,2-diolated nitric oxide donor ester prodrugs of aspirin, indomethacin and ibuprofen: synthesis, biological evalu... Bioorg Med Chem Lett. 2009 Jun 1;19(11):3014-8. DMIK7XV RU https://pubmed.ncbi.nlm.nih.gov/19419861 DMZKUOX DI DMZKUOX DMZKUOX DN 1,3-Di(berberine-9-O-yl)ethane dibromide DMZKUOX MI TT1RS9F DMZKUOX MN Acetylcholinesterase (AChE) DMZKUOX MT DTT DMZKUOX MA Inhibitor DMZKUOX RN Synthesis and biological evaluation of a new series of berberine derivatives as dual inhibitors of acetylcholinesterase and butyrylcholinesterase. Bioorg Med Chem. 2010 Jun 15;18(12):4475-84. DMZKUOX RU https://pubmed.ncbi.nlm.nih.gov/20471843 DMZKUOX DI DMZKUOX DMZKUOX DN 1,3-Di(berberine-9-O-yl)ethane dibromide DMZKUOX MI TTEB0GD DMZKUOX MN Cholinesterase (BCHE) DMZKUOX MT DTT DMZKUOX MA Inhibitor DMZKUOX RN Synthesis and biological evaluation of a new series of berberine derivatives as dual inhibitors of acetylcholinesterase and butyrylcholinesterase. Bioorg Med Chem. 2010 Jun 15;18(12):4475-84. DMZKUOX RU https://pubmed.ncbi.nlm.nih.gov/20471843 DMEV8G2 DI DMEV8G2 DMEV8G2 DN 1,3-Diallyl-3,7-dihydro-purine-2,6-dione DMEV8G2 MI TTK25J1 DMEV8G2 MN Adenosine A1 receptor (ADORA1) DMEV8G2 MT DTT DMEV8G2 MA Inhibitor DMEV8G2 RN Benzo[1,2-c:5,4-c']dipyrazoles: non-xanthine adenosine antagonists. J Med Chem. 1988 Oct;31(10):2034-9. DMEV8G2 RU https://pubmed.ncbi.nlm.nih.gov/3172141 DMEV8G2 DI DMEV8G2 DMEV8G2 DN 1,3-Diallyl-3,7-dihydro-purine-2,6-dione DMEV8G2 MI TTM2AOE DMEV8G2 MN Adenosine A2a receptor (ADORA2A) DMEV8G2 MT DTT DMEV8G2 MA Inhibitor DMEV8G2 RN Benzo[1,2-c:5,4-c']dipyrazoles: non-xanthine adenosine antagonists. J Med Chem. 1988 Oct;31(10):2034-9. DMEV8G2 RU https://pubmed.ncbi.nlm.nih.gov/3172141 DMEV8G2 DI DMEV8G2 DMEV8G2 DN 1,3-Diallyl-3,7-dihydro-purine-2,6-dione DMEV8G2 MI TTNE7KG DMEV8G2 MN Adenosine A2b receptor (ADORA2B) DMEV8G2 MT DTT DMEV8G2 MA Inhibitor DMEV8G2 RN Benzo[1,2-c:5,4-c']dipyrazoles: non-xanthine adenosine antagonists. J Med Chem. 1988 Oct;31(10):2034-9. DMEV8G2 RU https://pubmed.ncbi.nlm.nih.gov/3172141 DM4G2IE DI DM4G2IE DM4G2IE DN 1,3-Diallyl-7-methyl-3,7-dihydro-purine-2,6-dione DM4G2IE MI TTM2AOE DM4G2IE MN Adenosine A2a receptor (ADORA2A) DM4G2IE MT DTT DM4G2IE MA Inhibitor DM4G2IE RN Analogues of caffeine and theophylline: effect of structural alterations on affinity at adenosine receptors. J Med Chem. 1986 Jul;29(7):1305-8. DM4G2IE RU https://pubmed.ncbi.nlm.nih.gov/3806581 DMMOBPN DI DMMOBPN DMMOBPN DN 1,3-dibenzyl urea DMMOBPN MI TTMI6F5 DMMOBPN MN Transient receptor potential cation channel V1 (TRPV1) DMMOBPN MT DTT DMMOBPN MA Inhibitor DMMOBPN RN Rare dipeptide and urea derivatives from roots of Moringa oleifera as potential anti-inflammatory and antinociceptive agents. Eur J Med Chem. 2009 Jan;44(1):432-6. DMMOBPN RU https://pubmed.ncbi.nlm.nih.gov/18243423 DM8NARQ DI DM8NARQ DM8NARQ DN 1,3-Dibenzyl-[1,3]diazetidine-2,4-dione DM8NARQ MI TTQAJF1 DM8NARQ MN Cathepsin G (CTSG) DM8NARQ MT DTT DM8NARQ MA Inhibitor DM8NARQ RN Inhibition of serine proteases: activity of 1,3-diazetidine-2,4-diones. Bioorg Med Chem Lett. 2001 Jul 9;11(13):1691-4. DM8NARQ RU https://pubmed.ncbi.nlm.nih.gov/11425539 DM8NARQ DI DM8NARQ DM8NARQ DN 1,3-Dibenzyl-[1,3]diazetidine-2,4-dione DM8NARQ MI TT2WR1T DM8NARQ MN Cationic trypsinogen (PRSS1) DM8NARQ MT DTT DM8NARQ MA Inhibitor DM8NARQ RN Inhibition of serine proteases: activity of 1,3-diazetidine-2,4-diones. Bioorg Med Chem Lett. 2001 Jul 9;11(13):1691-4. DM8NARQ RU https://pubmed.ncbi.nlm.nih.gov/11425539 DM2WSG5 DI DM2WSG5 DM2WSG5 DN 1,3-Dibenzyl-3,7-dihydro-purine-2,6-dione DM2WSG5 MI TTM2AOE DM2WSG5 MN Adenosine A2a receptor (ADORA2A) DM2WSG5 MT DTT DM2WSG5 MA Inhibitor DM2WSG5 RN Analogues of caffeine and theophylline: effect of structural alterations on affinity at adenosine receptors. J Med Chem. 1986 Jul;29(7):1305-8. DM2WSG5 RU https://pubmed.ncbi.nlm.nih.gov/3806581 DMKYE16 DI DMKYE16 DMKYE16 DN 1,3-Diethyl-3,7-dihydro-purine-2,6-dione DMKYE16 MI TTK25J1 DMKYE16 MN Adenosine A1 receptor (ADORA1) DMKYE16 MT DTT DMKYE16 MA Inhibitor DMKYE16 RN Benzo[1,2-c:5,4-c']dipyrazoles: non-xanthine adenosine antagonists. J Med Chem. 1988 Oct;31(10):2034-9. DMKYE16 RU https://pubmed.ncbi.nlm.nih.gov/3172141 DMKYE16 DI DMKYE16 DMKYE16 DN 1,3-Diethyl-3,7-dihydro-purine-2,6-dione DMKYE16 MI TTM2AOE DMKYE16 MN Adenosine A2a receptor (ADORA2A) DMKYE16 MT DTT DMKYE16 MA Inhibitor DMKYE16 RN Benzo[1,2-c:5,4-c']dipyrazoles: non-xanthine adenosine antagonists. J Med Chem. 1988 Oct;31(10):2034-9. DMKYE16 RU https://pubmed.ncbi.nlm.nih.gov/3172141 DMKYE16 DI DMKYE16 DMKYE16 DN 1,3-Diethyl-3,7-dihydro-purine-2,6-dione DMKYE16 MI TTNE7KG DMKYE16 MN Adenosine A2b receptor (ADORA2B) DMKYE16 MT DTT DMKYE16 MA Inhibitor DMKYE16 RN Benzo[1,2-c:5,4-c']dipyrazoles: non-xanthine adenosine antagonists. J Med Chem. 1988 Oct;31(10):2034-9. DMKYE16 RU https://pubmed.ncbi.nlm.nih.gov/3172141 DMB9XR5 DI DMB9XR5 DMB9XR5 DN 1,3-Dihydro-imidazo[4,5-b]quinolin-2-one DMB9XR5 MI TT06AWU DMB9XR5 MN Phosphodiesterase 3A (PDE3A) DMB9XR5 MT DTT DMB9XR5 MA Inhibitor DMB9XR5 RN 1,3-Dihydro-2H-imidazo[4,5-b]quinolin-2-ones--inhibitors of blood platelet cAMP phosphodiesterase and induced aggregation. J Med Chem. 1991 Sep;34(9):2906-16. DMB9XR5 RU https://pubmed.ncbi.nlm.nih.gov/1654430 DM8CYOP DI DM8CYOP DM8CYOP DN 1,3-Dihydro-naphtho[2,3-d]imidazol-2-one DM8CYOP MI TT06AWU DM8CYOP MN Phosphodiesterase 3A (PDE3A) DM8CYOP MT DTT DM8CYOP MA Inhibitor DM8CYOP RN 1,3-Dihydro-2H-imidazo[4,5-b]quinolin-2-ones--inhibitors of blood platelet cAMP phosphodiesterase and induced aggregation. J Med Chem. 1991 Sep;34(9):2906-16. DM8CYOP RU https://pubmed.ncbi.nlm.nih.gov/1654430 DMZ80CT DI DMZ80CT DMZ80CT DN 1,3-Diisobutyl-3,7-dihydro-purine-2,6-dione DMZ80CT MI TTK25J1 DMZ80CT MN Adenosine A1 receptor (ADORA1) DMZ80CT MT DTT DMZ80CT MA Inhibitor DMZ80CT RN Benzo[1,2-c:5,4-c']dipyrazoles: non-xanthine adenosine antagonists. J Med Chem. 1988 Oct;31(10):2034-9. DMZ80CT RU https://pubmed.ncbi.nlm.nih.gov/3172141 DMZ80CT DI DMZ80CT DMZ80CT DN 1,3-Diisobutyl-3,7-dihydro-purine-2,6-dione DMZ80CT MI TTM2AOE DMZ80CT MN Adenosine A2a receptor (ADORA2A) DMZ80CT MT DTT DMZ80CT MA Inhibitor DMZ80CT RN Analogues of caffeine and theophylline: effect of structural alterations on affinity at adenosine receptors. J Med Chem. 1986 Jul;29(7):1305-8. DMZ80CT RU https://pubmed.ncbi.nlm.nih.gov/3806581 DM1KND6 DI DM1KND6 DM1KND6 DN 1,3-Diphenyl-1H-chromeno[4,3-c]pyrazol-4-one DM1KND6 MI TT1MPAY DM1KND6 MN GABA(A) receptor alpha-1 (GABRA1) DM1KND6 MT DTT DM1KND6 MA Inhibitor DM1KND6 RN Synthesis, binding studies, and structure-activity relationships of 1-aryl-and 2-aryl[1]benzopyranopyrazol-4-ones, central benzodiazepine receptor ... J Med Chem. 1988 Jan;31(1):1-3. DM1KND6 RU https://pubmed.ncbi.nlm.nih.gov/2826782 DM1KND6 DI DM1KND6 DM1KND6 DN 1,3-Diphenyl-1H-chromeno[4,3-c]pyrazol-4-one DM1KND6 MI TT06RH5 DM1KND6 MN GABA(A) receptor gamma-2 (GABRG2) DM1KND6 MT DTT DM1KND6 MA Inhibitor DM1KND6 RN Synthesis, binding studies, and structure-activity relationships of 1-aryl-and 2-aryl[1]benzopyranopyrazol-4-ones, central benzodiazepine receptor ... J Med Chem. 1988 Jan;31(1):1-3. DM1KND6 RU https://pubmed.ncbi.nlm.nih.gov/2826782 DM1KND6 DI DM1KND6 DM1KND6 DN 1,3-Diphenyl-1H-chromeno[4,3-c]pyrazol-4-one DM1KND6 MI TTNJYV2 DM1KND6 MN Gamma-aminobutyric acid receptor (GAR) DM1KND6 MT DTT DM1KND6 MA Inhibitor DM1KND6 RN Synthesis, binding studies, and structure-activity relationships of 1-aryl-and 2-aryl[1]benzopyranopyrazol-4-ones, central benzodiazepine receptor ... J Med Chem. 1988 Jan;31(1):1-3. DM1KND6 RU https://pubmed.ncbi.nlm.nih.gov/2826782 DMI4H05 DI DMI4H05 DMI4H05 DN 1,3-DIPHENYLUREA DMI4H05 MI TT7WVHI DMI4H05 MN Soluble epoxide hydrolase (EPHX2) DMI4H05 MT DTT DMI4H05 MA Inhibitor DMI4H05 RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DMI4H05 RU https://pubmed.ncbi.nlm.nih.gov/10592235 DMUL2B3 DI DMUL2B3 DMUL2B3 DN 1,3-Dipropyl-3,7-dihydro-purine-2,6-dione DMUL2B3 MI TTK25J1 DMUL2B3 MN Adenosine A1 receptor (ADORA1) DMUL2B3 MT DTT DMUL2B3 MA Inhibitor DMUL2B3 RN Benzo[1,2-c:5,4-c']dipyrazoles: non-xanthine adenosine antagonists. J Med Chem. 1988 Oct;31(10):2034-9. DMUL2B3 RU https://pubmed.ncbi.nlm.nih.gov/3172141 DMUL2B3 DI DMUL2B3 DMUL2B3 DN 1,3-Dipropyl-3,7-dihydro-purine-2,6-dione DMUL2B3 MI TTM2AOE DMUL2B3 MN Adenosine A2a receptor (ADORA2A) DMUL2B3 MT DTT DMUL2B3 MA Inhibitor DMUL2B3 RN Benzo[1,2-c:5,4-c']dipyrazoles: non-xanthine adenosine antagonists. J Med Chem. 1988 Oct;31(10):2034-9. DMUL2B3 RU https://pubmed.ncbi.nlm.nih.gov/3172141 DMUL2B3 DI DMUL2B3 DMUL2B3 DN 1,3-Dipropyl-3,7-dihydro-purine-2,6-dione DMUL2B3 MI TTNE7KG DMUL2B3 MN Adenosine A2b receptor (ADORA2B) DMUL2B3 MT DTT DMUL2B3 MA Inhibitor DMUL2B3 RN Benzo[1,2-c:5,4-c']dipyrazoles: non-xanthine adenosine antagonists. J Med Chem. 1988 Oct;31(10):2034-9. DMUL2B3 RU https://pubmed.ncbi.nlm.nih.gov/3172141 DMHNUWG DI DMHNUWG DMHNUWG DN 1,3-Di-p-tolyl-[1,3]diazetidine-2,4-dione DMHNUWG MI TT2WR1T DMHNUWG MN Cationic trypsinogen (PRSS1) DMHNUWG MT DTT DMHNUWG MA Inhibitor DMHNUWG RN Inhibition of serine proteases: activity of 1,3-diazetidine-2,4-diones. Bioorg Med Chem Lett. 2001 Jul 9;11(13):1691-4. DMHNUWG RU https://pubmed.ncbi.nlm.nih.gov/11425539 DM04KS1 DI DM04KS1 DM04KS1 DN 1,3-ditolylguanidine DM04KS1 MI TTLD29N DM04KS1 MN Glutamate receptor ionotropic NMDA 1 (NMDAR1) DM04KS1 MT DTT DM04KS1 MA Inhibitor DM04KS1 RN Synthesis and pharmacological evaluation of N,N'-diarylguanidines as potent sodium channel blockers and anticonvulsant agents. J Med Chem. 1998 Aug 13;41(17):3298-302. DM04KS1 RU https://pubmed.ncbi.nlm.nih.gov/9703475 DM04KS1 DI DM04KS1 DM04KS1 DN 1,3-ditolylguanidine DM04KS1 MI TTKJEMQ DM04KS1 MN Glutamate receptor ionotropic NMDA 2A (NMDAR2A) DM04KS1 MT DTT DM04KS1 MA Inhibitor DM04KS1 RN Synthesis and pharmacological evaluation of N,N'-diarylguanidines as potent sodium channel blockers and anticonvulsant agents. J Med Chem. 1998 Aug 13;41(17):3298-302. DM04KS1 RU https://pubmed.ncbi.nlm.nih.gov/9703475 DM04KS1 DI DM04KS1 DM04KS1 DN 1,3-ditolylguanidine DM04KS1 MI TTN9D8E DM04KS1 MN Glutamate receptor ionotropic NMDA 2B (NMDAR2B) DM04KS1 MT DTT DM04KS1 MA Inhibitor DM04KS1 RN Synthesis and pharmacological evaluation of N,N'-diarylguanidines as potent sodium channel blockers and anticonvulsant agents. J Med Chem. 1998 Aug 13;41(17):3298-302. DM04KS1 RU https://pubmed.ncbi.nlm.nih.gov/9703475 DM04KS1 DI DM04KS1 DM04KS1 DN 1,3-ditolylguanidine DM04KS1 MI TT5TPI6 DM04KS1 MN Opioid receptor sigma 1 (OPRS1) DM04KS1 MT DTT DM04KS1 MA Agonist DM04KS1 RN Sigma1 and sigma2 receptor binding affinity and selectivity of SA4503 and fluoroethyl SA4503. Synapse. 2006 May;59(6):350-8. DM04KS1 RU https://pubmed.ncbi.nlm.nih.gov/16463398 DM04KS1 DI DM04KS1 DM04KS1 DN 1,3-ditolylguanidine DM04KS1 MI TT9NXW4 DM04KS1 MN Sigma intracellular receptor 2 (TMEM97) DM04KS1 MT DTT DM04KS1 MA Agonist DM04KS1 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2553). DM04KS1 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2553 DMVBI2C DI DMVBI2C DMVBI2C DN 1,3-propanediphosphonic acid DMVBI2C MI TTU6BFZ DMVBI2C MN Candida Thymidylate synthase (Candi TMP1) DMVBI2C MT DTT DMVBI2C MA Inhibitor DMVBI2C RN Novel approaches for targeting thymidylate synthase to overcome the resistance and toxicity of anticancer drugs. J Med Chem. 2010 Sep 23;53(18):6539-49. DMVBI2C RU https://pubmed.ncbi.nlm.nih.gov/20527892 DMLBHXN DI DMLBHXN DMLBHXN DN 1,4-bis-(Dmt-Tic-amino)butane DMLBHXN MI TT27RFC DMLBHXN MN Opioid receptor delta (OPRD1) DMLBHXN MT DTT DMLBHXN MA Inhibitor DMLBHXN RN Potent Dmt-Tic pharmacophoric delta- and mu-opioid receptor antagonists. J Med Chem. 2005 Dec 15;48(25):8035-44. DMLBHXN RU https://pubmed.ncbi.nlm.nih.gov/16335927 DMLBHXN DI DMLBHXN DMLBHXN DN 1,4-bis-(Dmt-Tic-amino)butane DMLBHXN MI TTKWM86 DMLBHXN MN Opioid receptor mu (MOP) DMLBHXN MT DTT DMLBHXN MA Inhibitor DMLBHXN RN Potent Dmt-Tic pharmacophoric delta- and mu-opioid receptor antagonists. J Med Chem. 2005 Dec 15;48(25):8035-44. DMLBHXN RU https://pubmed.ncbi.nlm.nih.gov/16335927 DMC4LMT DI DMC4LMT DMC4LMT DN 1,4-bis(malimido)xylene DMC4LMT MI TTDP1UC DMC4LMT MN Fatty acid amide hydrolase (FAAH) DMC4LMT MT DTT DMC4LMT MA Inhibitor DMC4LMT RN Synthesis and in vitro evaluation of N-substituted maleimide derivatives as selective monoglyceride lipase inhibitors. J Med Chem. 2009 Dec 10;52(23):7410-20. DMC4LMT RU https://pubmed.ncbi.nlm.nih.gov/19583260 DMVHKZT DI DMVHKZT DMVHKZT DN 1,4-Butanediol DMVHKZT MI TTO8QRU DMVHKZT MN Group IIA phospholipase A2 (GIIA sPLA2) DMVHKZT MT DTT DMVHKZT MA Inhibitor DMVHKZT RN Drosophila metabolize 1,4-butanediol into gamma-hydroxybutyric acid in vivo. Eur J Pharmacol. 2003 Jul 25;473(2-3):149-52. DMVHKZT RU https://pubmed.ncbi.nlm.nih.gov/12892832 DM87MWN DI DM87MWN DM87MWN DN 1,4-Di(berberine-9-O-yl)ethane dibromide DM87MWN MI TT1RS9F DM87MWN MN Acetylcholinesterase (AChE) DM87MWN MT DTT DM87MWN MA Inhibitor DM87MWN RN Synthesis and biological evaluation of a new series of berberine derivatives as dual inhibitors of acetylcholinesterase and butyrylcholinesterase. Bioorg Med Chem. 2010 Jun 15;18(12):4475-84. DM87MWN RU https://pubmed.ncbi.nlm.nih.gov/20471843 DM87MWN DI DM87MWN DM87MWN DN 1,4-Di(berberine-9-O-yl)ethane dibromide DM87MWN MI TTEB0GD DM87MWN MN Cholinesterase (BCHE) DM87MWN MT DTT DM87MWN MA Inhibitor DM87MWN RN Synthesis and biological evaluation of a new series of berberine derivatives as dual inhibitors of acetylcholinesterase and butyrylcholinesterase. Bioorg Med Chem. 2010 Jun 15;18(12):4475-84. DM87MWN RU https://pubmed.ncbi.nlm.nih.gov/20471843 DMIHYKG DI DMIHYKG DMIHYKG DN 1,4-diaminoanthracene-9,10-dione DMIHYKG MI TTM2AOE DMIHYKG MN Adenosine A2a receptor (ADORA2A) DMIHYKG MT DTT DMIHYKG MA Inhibitor DMIHYKG RN Structure-based discovery of novel chemotypes for adenosine A(2A) receptor antagonists. J Med Chem. 2010 Feb 25;53(4):1799-809. DMIHYKG RU https://pubmed.ncbi.nlm.nih.gov/20095623 DMB5VQK DI DMB5VQK DMB5VQK DN 1,4-dideoxy-1,4-imino-D-arabinito DMB5VQK MI TTXWASR DMB5VQK MN Intestinal maltase-glucoamylase (MGAM) DMB5VQK MT DTT DMB5VQK MA Inhibitor DMB5VQK RN New sugar-mimic alkaloids from the pods of Angylocalyx pynaertii. J Nat Prod. 2002 Feb;65(2):198-202. DMB5VQK RU https://pubmed.ncbi.nlm.nih.gov/11858756 DM4RD2S DI DM4RD2S DM4RD2S DN 1,4-Dideoxy-5-Dehydro-O2-Sulfo-Glucuronic Acid DM4RD2S MI TTGKIED DM4RD2S MN Fibroblast growth factor-2 (FGF2) DM4RD2S MT DTT DM4RD2S MA Inhibitor DM4RD2S RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DM4RD2S RU https://pubmed.ncbi.nlm.nih.gov/17139284 DM9KUQZ DI DM9KUQZ DM9KUQZ DN 1,4-Dideoxy-O2-Sulfo-Glucuronic Acid DM9KUQZ MI TTGKIED DM9KUQZ MN Fibroblast growth factor-2 (FGF2) DM9KUQZ MT DTT DM9KUQZ MA Inhibitor DM9KUQZ RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DM9KUQZ RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMI36WC DI DMI36WC DMI36WC DN 1,4-Diethylene Dioxide DMI36WC MI TTWMIDN DMI36WC MN B-cell-activating factor (TNFSF13B) DMI36WC MT DTT DMI36WC MA Inhibitor DMI36WC RN DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Nucleic Acids Res. 2011 Jan;39(Database issue):D1035-41. DMI36WC RU https://pubmed.ncbi.nlm.nih.gov/21059682 DMNHGVD DI DMNHGVD DMNHGVD DN 1,4-Dihydro-1-methyl-4-oxo-3-pyridinesulfonamide DMNHGVD MI TTHQPL7 DMNHGVD MN Carbonic anhydrase I (CA-I) DMNHGVD MT DTT DMNHGVD MA Inhibitor DMNHGVD RN Carbonic anhydrase inhibitors. Regioselective synthesis of novel 1-substituted 1,4-dihydro-4-oxo-3-pyridinesulfonamides and their inhibition of the... Eur J Med Chem. 2010 Sep;45(9):3656-61. DMNHGVD RU https://pubmed.ncbi.nlm.nih.gov/20554082 DMNHGVD DI DMNHGVD DMNHGVD DN 1,4-Dihydro-1-methyl-4-oxo-3-pyridinesulfonamide DMNHGVD MI TTANPDJ DMNHGVD MN Carbonic anhydrase II (CA-II) DMNHGVD MT DTT DMNHGVD MA Inhibitor DMNHGVD RN Carbonic anhydrase inhibitors. Regioselective synthesis of novel 1-substituted 1,4-dihydro-4-oxo-3-pyridinesulfonamides and their inhibition of the... Eur J Med Chem. 2010 Sep;45(9):3656-61. DMNHGVD RU https://pubmed.ncbi.nlm.nih.gov/20554082 DMNHGVD DI DMNHGVD DMNHGVD DN 1,4-Dihydro-1-methyl-4-oxo-3-pyridinesulfonamide DMNHGVD MI TT2LVK8 DMNHGVD MN Carbonic anhydrase IX (CA-IX) DMNHGVD MT DTT DMNHGVD MA Inhibitor DMNHGVD RN Carbonic anhydrase inhibitors. Regioselective synthesis of novel 1-substituted 1,4-dihydro-4-oxo-3-pyridinesulfonamides and their inhibition of the... Eur J Med Chem. 2010 Sep;45(9):3656-61. DMNHGVD RU https://pubmed.ncbi.nlm.nih.gov/20554082 DMNHGVD DI DMNHGVD DMNHGVD DN 1,4-Dihydro-1-methyl-4-oxo-3-pyridinesulfonamide DMNHGVD MI TTSYM0R DMNHGVD MN Carbonic anhydrase XII (CA-XII) DMNHGVD MT DTT DMNHGVD MA Inhibitor DMNHGVD RN Carbonic anhydrase inhibitors. Regioselective synthesis of novel 1-substituted 1,4-dihydro-4-oxo-3-pyridinesulfonamides and their inhibition of the... Eur J Med Chem. 2010 Sep;45(9):3656-61. DMNHGVD RU https://pubmed.ncbi.nlm.nih.gov/20554082 DMMGP9X DI DMMGP9X DMMGP9X DN 1,4-dihydroindeno[1,2-c]-pyrazole DMMGP9X MI TT6OEDT DMMGP9X MN Cannabinoid receptor 1 (CB1) DMMGP9X MT DTT DMMGP9X MA Inhibitor DMMGP9X RN Tricyclic pyrazoles. 3. Synthesis, biological evaluation, and molecular modeling of analogues of the cannabinoid antagonist 8-chloro-1-(2',4'-dichl... J Med Chem. 2005 Nov 17;48(23):7351-62. DMMGP9X RU https://pubmed.ncbi.nlm.nih.gov/16279795 DMMGP9X DI DMMGP9X DMMGP9X DN 1,4-dihydroindeno[1,2-c]-pyrazole DMMGP9X MI TTMSFAW DMMGP9X MN Cannabinoid receptor 2 (CB2) DMMGP9X MT DTT DMMGP9X MA Inhibitor DMMGP9X RN Tricyclic pyrazoles. 3. Synthesis, biological evaluation, and molecular modeling of analogues of the cannabinoid antagonist 8-chloro-1-(2',4'-dichl... J Med Chem. 2005 Nov 17;48(23):7351-62. DMMGP9X RU https://pubmed.ncbi.nlm.nih.gov/16279795 DMRT13B DI DMRT13B DMRT13B DN 1,4-Dimethylquinolin-2(1H)-one DMRT13B MI TTJLP0R DMRT13B MN Quinone reductase 2 (NQO2) DMRT13B MT DTT DMRT13B MA Inhibitor DMRT13B RN Synthesis of casimiroin and optimization of its quinone reductase 2 and aromatase inhibitory activities. J Med Chem. 2009 Apr 9;52(7):1873-84. DMRT13B RU https://pubmed.ncbi.nlm.nih.gov/19265439 DMFY3VS DI DMFY3VS DMFY3VS DN 1,4-diphenyl-(1E,3E)-1,3-butadiene DMFY3VS MI TTGP7BY DMFY3VS MN Monoamine oxidase type B (MAO-B) DMFY3VS MT DTT DMFY3VS MA Inhibitor DMFY3VS RN Docking studies on monoamine oxidase-B inhibitors: estimation of inhibition constants (K(i)) of a series of experimentally tested compounds. Bioorg Med Chem Lett. 2005 Oct 15;15(20):4438-46. DMFY3VS RU https://pubmed.ncbi.nlm.nih.gov/16137882 DMIFOXE DI DMIFOXE DMIFOXE DN 1,4-Dithiothreitol DMIFOXE MI TTU6BFZ DMIFOXE MN Candida Thymidylate synthase (Candi TMP1) DMIFOXE MT DTT DMIFOXE MA Inhibitor DMIFOXE RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMIFOXE RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMIFOXE DI DMIFOXE DMIFOXE DN 1,4-Dithiothreitol DMIFOXE MI TTPADOQ DMIFOXE MN HMG-CoA reductase (HMGCR) DMIFOXE MT DTT DMIFOXE MA Inhibitor DMIFOXE RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMIFOXE RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMIFOXE DI DMIFOXE DMIFOXE DN 1,4-Dithiothreitol DMIFOXE MI TT6ZFQ4 DMIFOXE MN Rotamase B (PPIB) DMIFOXE MT DTT DMIFOXE MA Inhibitor DMIFOXE RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMIFOXE RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMTCMH7 DI DMTCMH7 DMTCMH7 DN 1,4-Naphthoquinone DMTCMH7 MI TTZJYKH DMTCMH7 MN Indoleamine 2,3-dioxygenase 1 (IDO1) DMTCMH7 MT DTT DMTCMH7 MA Inhibitor DMTCMH7 RN Indoleamine 2,3-dioxygenase is the anticancer target for a novel series of potent naphthoquinone-based inhibitors. J Med Chem. 2008 Mar 27;51(6):1706-18. DMTCMH7 RU https://pubmed.ncbi.nlm.nih.gov/18318466 DMTCMH7 DI DMTCMH7 DMTCMH7 DN 1,4-Naphthoquinone DMTCMH7 MI TT3PQ2Y DMTCMH7 MN Plasmodium Dihydroorotate dehydrogenase (Malaria DHOdehase) DMTCMH7 MT DTT DMTCMH7 MA Inhibitor DMTCMH7 RN Kinetics of inhibition of human and rat dihydroorotate dehydrogenase by atovaquone, lawsone derivatives, brequinar sodium and polyporic acid. Chem Biol Interact. 2000 Jan 3;124(1):61-76. DMTCMH7 RU https://pubmed.ncbi.nlm.nih.gov/10658902 DMTCMH7 DI DMTCMH7 DMTCMH7 DN 1,4-Naphthoquinone DMTCMH7 MI DEGLTNR DMTCMH7 MN Sulfide-quinone reductase (SQR) DMTCMH7 MT DME DMTCMH7 MA Metabolism DMTCMH7 RN The quinone-binding site of Acidithiobacillus ferrooxidans sulfide: quinone oxidoreductase controls both sulfide oxidation and quinone reduction. Biochem Cell Biol. 2016 Apr;94(2):159-66. DMTCMH7 RU https://pubmed.ncbi.nlm.nih.gov/26914540 DMEDBO2 DI DMEDBO2 DMEDBO2 DN 1,4-phenylene disulfamate DMEDBO2 MI TTANPDJ DMEDBO2 MN Carbonic anhydrase II (CA-II) DMEDBO2 MT DTT DMEDBO2 MA Inhibitor DMEDBO2 RN Ligand-based and structure-based virtual screening to identify carbonic anhydrase IX inhibitors. Bioorg Med Chem. 2009 Jan 15;17(2):553-7. DMEDBO2 RU https://pubmed.ncbi.nlm.nih.gov/19097911 DMEDBO2 DI DMEDBO2 DMEDBO2 DN 1,4-phenylene disulfamate DMEDBO2 MI TT2LVK8 DMEDBO2 MN Carbonic anhydrase IX (CA-IX) DMEDBO2 MT DTT DMEDBO2 MA Inhibitor DMEDBO2 RN Ligand-based and structure-based virtual screening to identify carbonic anhydrase IX inhibitors. Bioorg Med Chem. 2009 Jan 15;17(2):553-7. DMEDBO2 RU https://pubmed.ncbi.nlm.nih.gov/19097911 DMF0RXK DI DMF0RXK DMF0RXK DN 1,5-bis(4-chlorophenyl)-1H-1,2,3-triazole DMF0RXK MI TT6OEDT DMF0RXK MN Cannabinoid receptor 1 (CB1) DMF0RXK MT DTT DMF0RXK MA Inhibitor DMF0RXK RN Synthesis and CB1 cannabinoid receptor affinity of 4-alkoxycarbonyl-1,5-diaryl-1,2,3-triazoles. Bioorg Med Chem Lett. 2009 Feb 1;19(3):891-3. DMF0RXK RU https://pubmed.ncbi.nlm.nih.gov/19097888 DMPOAB7 DI DMPOAB7 DMPOAB7 DN 1,5-bis(4-hydroxyphenyl)penta-1,4-dien-3-one DMPOAB7 MI TTVG215 DMPOAB7 MN Debrisoquine 4-hydroxylase (CYP2D6) DMPOAB7 MT DTT DMPOAB7 MA Inhibitor DMPOAB7 RN Structure-activity relationships for the inhibition of recombinant human cytochromes P450 by curcumin analogues. Eur J Med Chem. 2008 Aug;43(8):1621-31. DMPOAB7 RU https://pubmed.ncbi.nlm.nih.gov/18249473 DMZU1GD DI DMZU1GD DMZU1GD DN 1,5-Dideoxy-1,5-imino-D-xylitol DMZU1GD MI TT1B5PU DMZU1GD MN Glucosylceramidase (GBA) DMZU1GD MT DTT DMZU1GD MA Inhibitor DMZU1GD RN In vitro inhibition of glycogen-degrading enzymes and glycosidases by six-membered sugar mimics and their evaluation in cell cultures. Bioorg Med Chem. 2008 Aug 1;16(15):7330-6. DMZU1GD RU https://pubmed.ncbi.nlm.nih.gov/18595718 DMYA25G DI DMYA25G DMYA25G DN 1,5-Dihydro-imidazo[2,1-b]quinazolin-2-one DMYA25G MI TT06AWU DMYA25G MN Phosphodiesterase 3A (PDE3A) DMYA25G MT DTT DMYA25G MA Inhibitor DMYA25G RN Inhibitors of cyclic AMP phosphodiesterase. 3. Synthesis and biological evaluation of pyrido and imidazolyl analogues of 1,2,3,5-tetrahydro-2-oxoim... J Med Chem. 1988 Nov;31(11):2136-45. DMYA25G RU https://pubmed.ncbi.nlm.nih.gov/2846839 DMC7FLT DI DMC7FLT DMC7FLT DN 1,5-Dihydroxy-10H-anthracen-9-one DMC7FLT MI TT2J34L DMC7FLT MN Arachidonate 5-lipoxygenase (5-LOX) DMC7FLT MT DTT DMC7FLT MA Inhibitor DMC7FLT RN Simple analogues of anthralin: unusual specificity of structure and antiproliferative activity. J Med Chem. 1997 Nov 7;40(23):3773-80. DMC7FLT RU https://pubmed.ncbi.nlm.nih.gov/9371243 DMDFU6S DI DMDFU6S DMDFU6S DN 1,6-bis(4-(3-chlorophenyl)piperazin-1-yl)hexane DMDFU6S MI TTSQIFT DMDFU6S MN 5-HT 1A receptor (HTR1A) DMDFU6S MT DTT DMDFU6S MA Inhibitor DMDFU6S RN Discovery of bishomo(hetero)arylpiperazines as novel multifunctional ligands targeting dopamine D(3) and serotonin 5-HT(1A) and 5-HT(2A) receptors. J Med Chem. 2010 Jun 24;53(12):4803-7. DMDFU6S RU https://pubmed.ncbi.nlm.nih.gov/20481570 DMDFU6S DI DMDFU6S DMDFU6S DN 1,6-bis(4-(3-chlorophenyl)piperazin-1-yl)hexane DMDFU6S MI TTJQOD7 DMDFU6S MN 5-HT 2A receptor (HTR2A) DMDFU6S MT DTT DMDFU6S MA Inhibitor DMDFU6S RN Discovery of bishomo(hetero)arylpiperazines as novel multifunctional ligands targeting dopamine D(3) and serotonin 5-HT(1A) and 5-HT(2A) receptors. J Med Chem. 2010 Jun 24;53(12):4803-7. DMDFU6S RU https://pubmed.ncbi.nlm.nih.gov/20481570 DMDFU6S DI DMDFU6S DMDFU6S DN 1,6-bis(4-(3-chlorophenyl)piperazin-1-yl)hexane DMDFU6S MI TTEX248 DMDFU6S MN Dopamine D2 receptor (D2R) DMDFU6S MT DTT DMDFU6S MA Inhibitor DMDFU6S RN Discovery of bishomo(hetero)arylpiperazines as novel multifunctional ligands targeting dopamine D(3) and serotonin 5-HT(1A) and 5-HT(2A) receptors. J Med Chem. 2010 Jun 24;53(12):4803-7. DMDFU6S RU https://pubmed.ncbi.nlm.nih.gov/20481570 DMDFU6S DI DMDFU6S DMDFU6S DN 1,6-bis(4-(3-chlorophenyl)piperazin-1-yl)hexane DMDFU6S MI TTQ6VDM DMDFU6S MN Voltage-gated potassium channel Kv11.1 (KCNH2) DMDFU6S MT DTT DMDFU6S MA Inhibitor DMDFU6S RN Discovery of bishomo(hetero)arylpiperazines as novel multifunctional ligands targeting dopamine D(3) and serotonin 5-HT(1A) and 5-HT(2A) receptors. J Med Chem. 2010 Jun 24;53(12):4803-7. DMDFU6S RU https://pubmed.ncbi.nlm.nih.gov/20481570 DMNLUKS DI DMNLUKS DMNLUKS DN 1,6-bis(4-(3-methoxyphenyl)piperazin-1-yl)hexane DMNLUKS MI TTSQIFT DMNLUKS MN 5-HT 1A receptor (HTR1A) DMNLUKS MT DTT DMNLUKS MA Inhibitor DMNLUKS RN Discovery of bishomo(hetero)arylpiperazines as novel multifunctional ligands targeting dopamine D(3) and serotonin 5-HT(1A) and 5-HT(2A) receptors. J Med Chem. 2010 Jun 24;53(12):4803-7. DMNLUKS RU https://pubmed.ncbi.nlm.nih.gov/20481570 DMNLUKS DI DMNLUKS DMNLUKS DN 1,6-bis(4-(3-methoxyphenyl)piperazin-1-yl)hexane DMNLUKS MI TTJQOD7 DMNLUKS MN 5-HT 2A receptor (HTR2A) DMNLUKS MT DTT DMNLUKS MA Inhibitor DMNLUKS RN Discovery of bishomo(hetero)arylpiperazines as novel multifunctional ligands targeting dopamine D(3) and serotonin 5-HT(1A) and 5-HT(2A) receptors. J Med Chem. 2010 Jun 24;53(12):4803-7. DMNLUKS RU https://pubmed.ncbi.nlm.nih.gov/20481570 DMNLUKS DI DMNLUKS DMNLUKS DN 1,6-bis(4-(3-methoxyphenyl)piperazin-1-yl)hexane DMNLUKS MI TTEX248 DMNLUKS MN Dopamine D2 receptor (D2R) DMNLUKS MT DTT DMNLUKS MA Inhibitor DMNLUKS RN Discovery of bishomo(hetero)arylpiperazines as novel multifunctional ligands targeting dopamine D(3) and serotonin 5-HT(1A) and 5-HT(2A) receptors. J Med Chem. 2010 Jun 24;53(12):4803-7. DMNLUKS RU https://pubmed.ncbi.nlm.nih.gov/20481570 DMNLUKS DI DMNLUKS DMNLUKS DN 1,6-bis(4-(3-methoxyphenyl)piperazin-1-yl)hexane DMNLUKS MI TTQ6VDM DMNLUKS MN Voltage-gated potassium channel Kv11.1 (KCNH2) DMNLUKS MT DTT DMNLUKS MA Inhibitor DMNLUKS RN Discovery of bishomo(hetero)arylpiperazines as novel multifunctional ligands targeting dopamine D(3) and serotonin 5-HT(1A) and 5-HT(2A) receptors. J Med Chem. 2010 Jun 24;53(12):4803-7. DMNLUKS RU https://pubmed.ncbi.nlm.nih.gov/20481570 DM0GRMD DI DM0GRMD DM0GRMD DN 1,6-bis(4-(pyridin-2-yl)piperazin-1-yl)hexane DM0GRMD MI TTSQIFT DM0GRMD MN 5-HT 1A receptor (HTR1A) DM0GRMD MT DTT DM0GRMD MA Inhibitor DM0GRMD RN Discovery of bishomo(hetero)arylpiperazines as novel multifunctional ligands targeting dopamine D(3) and serotonin 5-HT(1A) and 5-HT(2A) receptors. J Med Chem. 2010 Jun 24;53(12):4803-7. DM0GRMD RU https://pubmed.ncbi.nlm.nih.gov/20481570 DM0GRMD DI DM0GRMD DM0GRMD DN 1,6-bis(4-(pyridin-2-yl)piperazin-1-yl)hexane DM0GRMD MI TTJQOD7 DM0GRMD MN 5-HT 2A receptor (HTR2A) DM0GRMD MT DTT DM0GRMD MA Inhibitor DM0GRMD RN Discovery of bishomo(hetero)arylpiperazines as novel multifunctional ligands targeting dopamine D(3) and serotonin 5-HT(1A) and 5-HT(2A) receptors. J Med Chem. 2010 Jun 24;53(12):4803-7. DM0GRMD RU https://pubmed.ncbi.nlm.nih.gov/20481570 DM0GRMD DI DM0GRMD DM0GRMD DN 1,6-bis(4-(pyridin-2-yl)piperazin-1-yl)hexane DM0GRMD MI TTEX248 DM0GRMD MN Dopamine D2 receptor (D2R) DM0GRMD MT DTT DM0GRMD MA Inhibitor DM0GRMD RN Discovery of bishomo(hetero)arylpiperazines as novel multifunctional ligands targeting dopamine D(3) and serotonin 5-HT(1A) and 5-HT(2A) receptors. J Med Chem. 2010 Jun 24;53(12):4803-7. DM0GRMD RU https://pubmed.ncbi.nlm.nih.gov/20481570 DM70ODN DI DM70ODN DM70ODN DN 1,6-bis(4'-aminophenyl)-hexa-1,3,5-triene DM70ODN MI TTE4KHA DM70ODN MN Amyloid beta A4 protein (APP) DM70ODN MT DTT DM70ODN MA Inhibitor DM70ODN RN Synthesis of biphenyltrienes as probes for beta-amyloid plaques. J Med Chem. 2006 May 4;49(9):2841-4. DM70ODN RU https://pubmed.ncbi.nlm.nih.gov/16640346 DMBCU6W DI DMBCU6W DMBCU6W DN 1,6-bis(4'-dimethylaminophenyl)-hexa-1,3,5-triene DMBCU6W MI TTE4KHA DMBCU6W MN Amyloid beta A4 protein (APP) DMBCU6W MT DTT DMBCU6W MA Inhibitor DMBCU6W RN Synthesis of biphenyltrienes as probes for beta-amyloid plaques. J Med Chem. 2006 May 4;49(9):2841-4. DMBCU6W RU https://pubmed.ncbi.nlm.nih.gov/16640346 DMEU3MN DI DMEU3MN DMEU3MN DN 1,6-Bis(4'-hydroxyphenyl)-hexa-1,3,5-triene DMEU3MN MI TTE4KHA DMEU3MN MN Amyloid beta A4 protein (APP) DMEU3MN MT DTT DMEU3MN MA Inhibitor DMEU3MN RN Synthesis of biphenyltrienes as probes for beta-amyloid plaques. J Med Chem. 2006 May 4;49(9):2841-4. DMEU3MN RU https://pubmed.ncbi.nlm.nih.gov/16640346 DM0D6JN DI DM0D6JN DM0D6JN DN 1,6-bis(4'-methylaminophenyl)-hexa-1,3,5-triene DM0D6JN MI TTE4KHA DM0D6JN MN Amyloid beta A4 protein (APP) DM0D6JN MT DTT DM0D6JN MA Inhibitor DM0D6JN RN Synthesis of biphenyltrienes as probes for beta-amyloid plaques. J Med Chem. 2006 May 4;49(9):2841-4. DM0D6JN RU https://pubmed.ncbi.nlm.nih.gov/16640346 DM5Z6XG DI DM5Z6XG DM5Z6XG DN 1,6-bis(4-m-tolylpiperazin-1-yl)hexane DM5Z6XG MI TTSQIFT DM5Z6XG MN 5-HT 1A receptor (HTR1A) DM5Z6XG MT DTT DM5Z6XG MA Inhibitor DM5Z6XG RN Discovery of bishomo(hetero)arylpiperazines as novel multifunctional ligands targeting dopamine D(3) and serotonin 5-HT(1A) and 5-HT(2A) receptors. J Med Chem. 2010 Jun 24;53(12):4803-7. DM5Z6XG RU https://pubmed.ncbi.nlm.nih.gov/20481570 DM5Z6XG DI DM5Z6XG DM5Z6XG DN 1,6-bis(4-m-tolylpiperazin-1-yl)hexane DM5Z6XG MI TTJQOD7 DM5Z6XG MN 5-HT 2A receptor (HTR2A) DM5Z6XG MT DTT DM5Z6XG MA Inhibitor DM5Z6XG RN Discovery of bishomo(hetero)arylpiperazines as novel multifunctional ligands targeting dopamine D(3) and serotonin 5-HT(1A) and 5-HT(2A) receptors. J Med Chem. 2010 Jun 24;53(12):4803-7. DM5Z6XG RU https://pubmed.ncbi.nlm.nih.gov/20481570 DM5Z6XG DI DM5Z6XG DM5Z6XG DN 1,6-bis(4-m-tolylpiperazin-1-yl)hexane DM5Z6XG MI TTEX248 DM5Z6XG MN Dopamine D2 receptor (D2R) DM5Z6XG MT DTT DM5Z6XG MA Inhibitor DM5Z6XG RN Discovery of bishomo(hetero)arylpiperazines as novel multifunctional ligands targeting dopamine D(3) and serotonin 5-HT(1A) and 5-HT(2A) receptors. J Med Chem. 2010 Jun 24;53(12):4803-7. DM5Z6XG RU https://pubmed.ncbi.nlm.nih.gov/20481570 DM5Z6XG DI DM5Z6XG DM5Z6XG DN 1,6-bis(4-m-tolylpiperazin-1-yl)hexane DM5Z6XG MI TTQ6VDM DM5Z6XG MN Voltage-gated potassium channel Kv11.1 (KCNH2) DM5Z6XG MT DTT DM5Z6XG MA Inhibitor DM5Z6XG RN Discovery of bishomo(hetero)arylpiperazines as novel multifunctional ligands targeting dopamine D(3) and serotonin 5-HT(1A) and 5-HT(2A) receptors. J Med Chem. 2010 Jun 24;53(12):4803-7. DM5Z6XG RU https://pubmed.ncbi.nlm.nih.gov/20481570 DMQY75B DI DMQY75B DMQY75B DN 1,6-bis(4'-nitrophenyl)-hexa-1,3,5-triene DMQY75B MI TTE4KHA DMQY75B MN Amyloid beta A4 protein (APP) DMQY75B MT DTT DMQY75B MA Inhibitor DMQY75B RN Synthesis of biphenyltrienes as probes for beta-amyloid plaques. J Med Chem. 2006 May 4;49(9):2841-4. DMQY75B RU https://pubmed.ncbi.nlm.nih.gov/16640346 DMD3EUI DI DMD3EUI DMD3EUI DN 1,6-bis(4-phenylpiperazin-1-yl)hexane DMD3EUI MI TTSQIFT DMD3EUI MN 5-HT 1A receptor (HTR1A) DMD3EUI MT DTT DMD3EUI MA Inhibitor DMD3EUI RN Discovery of bishomo(hetero)arylpiperazines as novel multifunctional ligands targeting dopamine D(3) and serotonin 5-HT(1A) and 5-HT(2A) receptors. J Med Chem. 2010 Jun 24;53(12):4803-7. DMD3EUI RU https://pubmed.ncbi.nlm.nih.gov/20481570 DMD3EUI DI DMD3EUI DMD3EUI DN 1,6-bis(4-phenylpiperazin-1-yl)hexane DMD3EUI MI TTJQOD7 DMD3EUI MN 5-HT 2A receptor (HTR2A) DMD3EUI MT DTT DMD3EUI MA Inhibitor DMD3EUI RN Discovery of bishomo(hetero)arylpiperazines as novel multifunctional ligands targeting dopamine D(3) and serotonin 5-HT(1A) and 5-HT(2A) receptors. J Med Chem. 2010 Jun 24;53(12):4803-7. DMD3EUI RU https://pubmed.ncbi.nlm.nih.gov/20481570 DMD3EUI DI DMD3EUI DMD3EUI DN 1,6-bis(4-phenylpiperazin-1-yl)hexane DMD3EUI MI TTEX248 DMD3EUI MN Dopamine D2 receptor (D2R) DMD3EUI MT DTT DMD3EUI MA Inhibitor DMD3EUI RN Discovery of bishomo(hetero)arylpiperazines as novel multifunctional ligands targeting dopamine D(3) and serotonin 5-HT(1A) and 5-HT(2A) receptors. J Med Chem. 2010 Jun 24;53(12):4803-7. DMD3EUI RU https://pubmed.ncbi.nlm.nih.gov/20481570 DMD3EUI DI DMD3EUI DMD3EUI DN 1,6-bis(4-phenylpiperazin-1-yl)hexane DMD3EUI MI TTQ6VDM DMD3EUI MN Voltage-gated potassium channel Kv11.1 (KCNH2) DMD3EUI MT DTT DMD3EUI MA Inhibitor DMD3EUI RN Discovery of bishomo(hetero)arylpiperazines as novel multifunctional ligands targeting dopamine D(3) and serotonin 5-HT(1A) and 5-HT(2A) receptors. J Med Chem. 2010 Jun 24;53(12):4803-7. DMD3EUI RU https://pubmed.ncbi.nlm.nih.gov/20481570 DMRG2CU DI DMRG2CU DMRG2CU DN 1,6-bis-(Dmt-Tic-amino)hexane DMRG2CU MI TT27RFC DMRG2CU MN Opioid receptor delta (OPRD1) DMRG2CU MT DTT DMRG2CU MA Inhibitor DMRG2CU RN Potent Dmt-Tic pharmacophoric delta- and mu-opioid receptor antagonists. J Med Chem. 2005 Dec 15;48(25):8035-44. DMRG2CU RU https://pubmed.ncbi.nlm.nih.gov/16335927 DMRG2CU DI DMRG2CU DMRG2CU DN 1,6-bis-(Dmt-Tic-amino)hexane DMRG2CU MI TTKWM86 DMRG2CU MN Opioid receptor mu (MOP) DMRG2CU MT DTT DMRG2CU MA Inhibitor DMRG2CU RN Potent Dmt-Tic pharmacophoric delta- and mu-opioid receptor antagonists. J Med Chem. 2005 Dec 15;48(25):8035-44. DMRG2CU RU https://pubmed.ncbi.nlm.nih.gov/16335927 DMMUZK9 DI DMMUZK9 DMMUZK9 DN 1,6-bis-(N,N-dimethyl-Dmt-Tic-NH)hexane DMMUZK9 MI TT27RFC DMMUZK9 MN Opioid receptor delta (OPRD1) DMMUZK9 MT DTT DMMUZK9 MA Inhibitor DMMUZK9 RN Potent Dmt-Tic pharmacophoric delta- and mu-opioid receptor antagonists. J Med Chem. 2005 Dec 15;48(25):8035-44. DMMUZK9 RU https://pubmed.ncbi.nlm.nih.gov/16335927 DMMUZK9 DI DMMUZK9 DMMUZK9 DN 1,6-bis-(N,N-dimethyl-Dmt-Tic-NH)hexane DMMUZK9 MI TTKWM86 DMMUZK9 MN Opioid receptor mu (MOP) DMMUZK9 MT DTT DMMUZK9 MA Inhibitor DMMUZK9 RN Potent Dmt-Tic pharmacophoric delta- and mu-opioid receptor antagonists. J Med Chem. 2005 Dec 15;48(25):8035-44. DMMUZK9 RU https://pubmed.ncbi.nlm.nih.gov/16335927 DMLB3RT DI DMLB3RT DMLB3RT DN 1,6-hexamethylene diisocyanate DMLB3RT MI TTELV3W DMLB3RT MN Transformation-sensitive protein p120 (TRPA1) DMLB3RT MT DTT DMLB3RT MA Activator DMLB3RT RN Transient receptor potential ankyrin 1 antagonists block the noxious effects of toxic industrial isocyanates and tear gases. FASEB J. 2009 Apr;23(4):1102-14. DMLB3RT RU https://pubmed.ncbi.nlm.nih.gov/19036859 DMBU796 DI DMBU796 DMBU796 DN 1,7,8,9-tetrahydro-1,5-diaza-trindene-4,6-dione DMBU796 MI TTVDSZ0 DMBU796 MN Poly [ADP-ribose] polymerase 1 (PARP1) DMBU796 MT DTT DMBU796 MA Inhibitor DMBU796 RN Synthesis and structure-activity relationships of novel poly(ADP-ribose) polymerase-1 inhibitors. Bioorg Med Chem Lett. 2006 Feb 15;16(4):938-42. DMBU796 RU https://pubmed.ncbi.nlm.nih.gov/16290935 DMVHE1P DI DMVHE1P DMVHE1P DN 1,8,9-Trimethoxy-9,10-dihydro-anthracene DMVHE1P MI TT2J34L DMVHE1P MN Arachidonate 5-lipoxygenase (5-LOX) DMVHE1P MT DTT DMVHE1P MA Inhibitor DMVHE1P RN Simple analogues of anthralin: unusual specificity of structure and antiproliferative activity. J Med Chem. 1997 Nov 7;40(23):3773-80. DMVHE1P RU https://pubmed.ncbi.nlm.nih.gov/9371243 DMKJGTH DI DMKJGTH DMKJGTH DN 1,8-bis-maleimidodiethyleneglycol DMKJGTH MI TTDP1UC DMKJGTH MN Fatty acid amide hydrolase (FAAH) DMKJGTH MT DTT DMKJGTH MA Inhibitor DMKJGTH RN Synthesis and in vitro evaluation of N-substituted maleimide derivatives as selective monoglyceride lipase inhibitors. J Med Chem. 2009 Dec 10;52(23):7410-20. DMKJGTH RU https://pubmed.ncbi.nlm.nih.gov/19583260 DMZK4DL DI DMZK4DL DMZK4DL DN 1,8-Dichloro-10H-anthracen-9-one DMZK4DL MI TT2J34L DMZK4DL MN Arachidonate 5-lipoxygenase (5-LOX) DMZK4DL MT DTT DMZK4DL MA Inhibitor DMZK4DL RN Simple analogues of anthralin: unusual specificity of structure and antiproliferative activity. J Med Chem. 1997 Nov 7;40(23):3773-80. DMZK4DL RU https://pubmed.ncbi.nlm.nih.gov/9371243 DMKJBRZ DI DMKJBRZ DMKJBRZ DN 1,8-Dichloro-6-(4-hydroxy-phenyl)-naphthalen-2-ol DMKJBRZ MI TTZAYWL DMKJBRZ MN Estrogen receptor (ESR) DMKJBRZ MT DTT DMKJBRZ MA Inhibitor DMKJBRZ RN ERbeta ligands. 3. Exploiting two binding orientations of the 2-phenylnaphthalene scaffold to achieve ERbeta selectivity. J Med Chem. 2005 Jun 16;48(12):3953-79. DMKJBRZ RU https://pubmed.ncbi.nlm.nih.gov/15943471 DMKJBRZ DI DMKJBRZ DMKJBRZ DN 1,8-Dichloro-6-(4-hydroxy-phenyl)-naphthalen-2-ol DMKJBRZ MI TTOM3J0 DMKJBRZ MN Estrogen receptor beta (ESR2) DMKJBRZ MT DTT DMKJBRZ MA Inhibitor DMKJBRZ RN ERbeta ligands. 3. Exploiting two binding orientations of the 2-phenylnaphthalene scaffold to achieve ERbeta selectivity. J Med Chem. 2005 Jun 16;48(12):3953-79. DMKJBRZ RU https://pubmed.ncbi.nlm.nih.gov/15943471 DMDFBSX DI DMDFBSX DMDFBSX DN 1,8-Dihydroxy-2-propionyl-10H-anthracen-9-one DMDFBSX MI TT2J34L DMDFBSX MN Arachidonate 5-lipoxygenase (5-LOX) DMDFBSX MT DTT DMDFBSX MA Inhibitor DMDFBSX RN Simple analogues of anthralin: unusual specificity of structure and antiproliferative activity. J Med Chem. 1997 Nov 7;40(23):3773-80. DMDFBSX RU https://pubmed.ncbi.nlm.nih.gov/9371243 DMWC7QE DI DMWC7QE DMWC7QE DN 1,9-bis(pyridinium)-nonane dibromide DMWC7QE MI TT1RS9F DMWC7QE MN Acetylcholinesterase (AChE) DMWC7QE MT DTT DMWC7QE MA Inhibitor DMWC7QE RN Preparation and in vitro screening of symmetrical bispyridinium cholinesterase inhibitors bearing different connecting linkage-initial study for My... Bioorg Med Chem Lett. 2010 Mar 1;20(5):1763-6. DMWC7QE RU https://pubmed.ncbi.nlm.nih.gov/20138518 DMWC7QE DI DMWC7QE DMWC7QE DN 1,9-bis(pyridinium)-nonane dibromide DMWC7QE MI TTEB0GD DMWC7QE MN Cholinesterase (BCHE) DMWC7QE MT DTT DMWC7QE MA Inhibitor DMWC7QE RN Preparation and in vitro screening of symmetrical bispyridinium cholinesterase inhibitors bearing different connecting linkage-initial study for My... Bioorg Med Chem Lett. 2010 Mar 1;20(5):1763-6. DMWC7QE RU https://pubmed.ncbi.nlm.nih.gov/20138518 DMW613U DI DMW613U DMW613U DN 1,9-dideoxyforskolin DMW613U MI TT0FC1V DMW613U MN Volume regulated chloride channel (VRAC) DMW613U MT DTT DMW613U MA Blocker (channel blocker) DMW613U RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 710). DMW613U RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=710 DM7U0XW DI DM7U0XW DM7U0XW DN 1-[(3-Methoxybenzyl)amino]ethaniminium chloride DM7U0XW MI TTZUFI5 DM7U0XW MN Nitric-oxide synthase brain (NOS1) DM7U0XW MT DTT DM7U0XW MA Inhibitor DM7U0XW RN N-Substituted acetamidines and 2-methylimidazole derivatives as selective inhibitors of neuronal nitric oxide synthase. Bioorg Med Chem Lett. 2010 Nov 15;20(22):6495-9. DM7U0XW RU https://pubmed.ncbi.nlm.nih.gov/20933416 DM3UHDW DI DM3UHDW DM3UHDW DN 1-[(3-methoxybenzyl)oxy]-2-(2-phenylethyl)benzene DM3UHDW MI TTSQIFT DM3UHDW MN 5-HT 1A receptor (HTR1A) DM3UHDW MT DTT DM3UHDW MA Inhibitor DM3UHDW RN Arylmethyloxyphenyl derivatives: small molecules displaying P-glycoprotein inhibition. J Med Chem. 2006 Nov 2;49(22):6607-13. DM3UHDW RU https://pubmed.ncbi.nlm.nih.gov/17064079 DM3UHDW DI DM3UHDW DM3UHDW DN 1-[(3-methoxybenzyl)oxy]-2-(2-phenylethyl)benzene DM3UHDW MI TTEX248 DM3UHDW MN Dopamine D2 receptor (D2R) DM3UHDW MT DTT DM3UHDW MA Inhibitor DM3UHDW RN Arylmethyloxyphenyl derivatives: small molecules displaying P-glycoprotein inhibition. J Med Chem. 2006 Nov 2;49(22):6607-13. DM3UHDW RU https://pubmed.ncbi.nlm.nih.gov/17064079 DMNJMGK DI DMNJMGK DMNJMGK DN 1-[(7-Fluoronaphth-2-yl)methyl]-1H-imidazole DMNJMGK MI TTSZLWK DMNJMGK MN Aromatase (CYP19A1) DMNJMGK MT DTT DMNJMGK MA Inhibitor DMNJMGK RN Pharmacophore modeling strategies for the development of novel nonsteroidal inhibitors of human aromatase (CYP19). Bioorg Med Chem Lett. 2010 May 15;20(10):3050-64. DMNJMGK RU https://pubmed.ncbi.nlm.nih.gov/20413308 DM1JQPW DI DM1JQPW DM1JQPW DN 1-[(cyclohexylamino)ethyl]-1,1-bisphosphonicacid DM1JQPW MI TTIKWV4 DM1JQPW MN Geranyltranstransferase (FDPS) DM1JQPW MT DTT DM1JQPW MA Inhibitor DM1JQPW RN Synthesis and biological evaluation of 2-alkylaminoethyl-1,1-bisphosphonic acids against Trypanosoma cruzi and Toxoplasma gondii targeting farnesyl... Bioorg Med Chem. 2008 Mar 15;16(6):3283-90. DM1JQPW RU https://pubmed.ncbi.nlm.nih.gov/18096393 DMQPFT3 DI DMQPFT3 DMQPFT3 DN 1-[(Furan-2(5H)-one)-4-methyl]-desloratadine DMQPFT3 MI TTTIBOJ DMQPFT3 MN Histamine H1 receptor (H1R) DMQPFT3 MT DTT DMQPFT3 MA Inhibitor DMQPFT3 RN Stereoselective synthesis of desloratadine derivatives as antagonist of histamine. Bioorg Med Chem. 2010 Feb 15;18(4):1626-32. DMQPFT3 RU https://pubmed.ncbi.nlm.nih.gov/20110173 DM8VNYA DI DM8VNYA DM8VNYA DN 1-[(n-but-1-ylamino)ethyl]-1,1-bisphosphonic acid DM8VNYA MI TTIKWV4 DM8VNYA MN Geranyltranstransferase (FDPS) DM8VNYA MT DTT DM8VNYA MA Inhibitor DM8VNYA RN Synthesis and biological evaluation of 2-alkylaminoethyl-1,1-bisphosphonic acids against Trypanosoma cruzi and Toxoplasma gondii targeting farnesyl... Bioorg Med Chem. 2008 Mar 15;16(6):3283-90. DM8VNYA RU https://pubmed.ncbi.nlm.nih.gov/18096393 DM4ABTN DI DM4ABTN DM4ABTN DN 1-[(n-hex-1-ylamino)ethyl]-1,1-bisphosphonic acid DM4ABTN MI TTIKWV4 DM4ABTN MN Geranyltranstransferase (FDPS) DM4ABTN MT DTT DM4ABTN MA Inhibitor DM4ABTN RN Synthesis and biological evaluation of 2-alkylaminoethyl-1,1-bisphosphonic acids against Trypanosoma cruzi and Toxoplasma gondii targeting farnesyl... Bioorg Med Chem. 2008 Mar 15;16(6):3283-90. DM4ABTN RU https://pubmed.ncbi.nlm.nih.gov/18096393 DM9ZK0D DI DM9ZK0D DM9ZK0D DN 1-[(n-oct-1-ylamino)ethyl]-1,1-bisphosphonic acid DM9ZK0D MI TTIKWV4 DM9ZK0D MN Geranyltranstransferase (FDPS) DM9ZK0D MT DTT DM9ZK0D MA Inhibitor DM9ZK0D RN Synthesis and biological evaluation of 2-alkylaminoethyl-1,1-bisphosphonic acids against Trypanosoma cruzi and Toxoplasma gondii targeting farnesyl... Bioorg Med Chem. 2008 Mar 15;16(6):3283-90. DM9ZK0D RU https://pubmed.ncbi.nlm.nih.gov/18096393 DMCRHVI DI DMCRHVI DMCRHVI DN 1-[(prop-1-ylamino)ethyl]-1,1-bisphosphonic acid DMCRHVI MI TTIKWV4 DMCRHVI MN Geranyltranstransferase (FDPS) DMCRHVI MT DTT DMCRHVI MA Inhibitor DMCRHVI RN Synthesis and biological evaluation of 2-alkylaminoethyl-1,1-bisphosphonic acids against Trypanosoma cruzi and Toxoplasma gondii targeting farnesyl... Bioorg Med Chem. 2008 Mar 15;16(6):3283-90. DMCRHVI RU https://pubmed.ncbi.nlm.nih.gov/18096393 DMSCN8J DI DMSCN8J DMSCN8J DN 1-[(prop-2-ylamino)ethyl]-1,1-bisphosphonicacid DMSCN8J MI TTIKWV4 DMSCN8J MN Geranyltranstransferase (FDPS) DMSCN8J MT DTT DMSCN8J MA Inhibitor DMSCN8J RN Synthesis and biological evaluation of 2-alkylaminoethyl-1,1-bisphosphonic acids against Trypanosoma cruzi and Toxoplasma gondii targeting farnesyl... Bioorg Med Chem. 2008 Mar 15;16(6):3283-90. DMSCN8J RU https://pubmed.ncbi.nlm.nih.gov/18096393 DMLDY3H DI DMLDY3H DMLDY3H DN 1-[(tert-butylamino)ethyl]-1,1-bisphosphonicacid DMLDY3H MI TTIKWV4 DMLDY3H MN Geranyltranstransferase (FDPS) DMLDY3H MT DTT DMLDY3H MA Inhibitor DMLDY3H RN Synthesis and biological evaluation of 2-alkylaminoethyl-1,1-bisphosphonic acids against Trypanosoma cruzi and Toxoplasma gondii targeting farnesyl... Bioorg Med Chem. 2008 Mar 15;16(6):3283-90. DMLDY3H RU https://pubmed.ncbi.nlm.nih.gov/18096393 DMU3VWA DI DMU3VWA DMU3VWA DN 1-[(Z)-4-(triphenylmethoxy)-2-butenyl]thymine DMU3VWA MI TTP3QRF DMU3VWA MN Thymidine kinase 1 (TK1) DMU3VWA MT DTT DMU3VWA MA Inhibitor DMU3VWA RN N1-substituted thymine derivatives as mitochondrial thymidine kinase (TK-2) inhibitors. J Med Chem. 2006 Dec 28;49(26):7766-73. DMU3VWA RU https://pubmed.ncbi.nlm.nih.gov/17181158 DMU3VWA DI DMU3VWA DMU3VWA DN 1-[(Z)-4-(triphenylmethoxy)-2-butenyl]thymine DMU3VWA MI TT7KNZQ DMU3VWA MN Thymidine kinase 2 (Mt-TK2) DMU3VWA MT DTT DMU3VWA MA Inhibitor DMU3VWA RN N1-substituted thymine derivatives as mitochondrial thymidine kinase (TK-2) inhibitors. J Med Chem. 2006 Dec 28;49(26):7766-73. DMU3VWA RU https://pubmed.ncbi.nlm.nih.gov/17181158 DMIHBFO DI DMIHBFO DMIHBFO DN 1-[(Z)-4-trityloxy-2-butenyl]uracil DMIHBFO MI TTY8KJS DMIHBFO MN Bacterial Deoxyuridine triphosphate nucleotidohydrolase (Bact dut) DMIHBFO MT DTT DMIHBFO MA Inhibitor DMIHBFO RN Acyclic nucleoside analogues as inhibitors of Plasmodium falciparum dUTPase. J Med Chem. 2006 Jul 13;49(14):4183-95. DMIHBFO RU https://pubmed.ncbi.nlm.nih.gov/16821778 DMEHP8M DI DMEHP8M DMEHP8M DN 1-[2-(2,4,6-trimethyl-phenyl)-ethyl]-pyrrolidine DMEHP8M MI TT9JNIC DMEHP8M MN Histamine H3 receptor (H3R) DMEHP8M MT DTT DMEHP8M MA Inhibitor DMEHP8M RN In vitro SAR of pyrrolidine-containing histamine H3 receptor antagonists: trends across multiple chemical series. Bioorg Med Chem Lett. 2008 Jan 1;18(1):355-9. DMEHP8M RU https://pubmed.ncbi.nlm.nih.gov/18077160 DMTNRG7 DI DMTNRG7 DMTNRG7 DN 1-[2-(2-Benzyl-phenoxy)-ethyl]-piperidine DMTNRG7 MI TTZFYLI DMTNRG7 MN Dopamine D1 receptor (D1R) DMTNRG7 MT DTT DMTNRG7 MA Inhibitor DMTNRG7 RN Dopamine/serotonin receptor ligands. 9. Oxygen-containing midsized heterocyclic ring systems and nonrigidized analogues. A step toward dopamine D5 ... J Med Chem. 2004 Aug 12;47(17):4155-8. DMTNRG7 RU https://pubmed.ncbi.nlm.nih.gov/15293986 DMTNRG7 DI DMTNRG7 DMTNRG7 DN 1-[2-(2-Benzyl-phenoxy)-ethyl]-piperidine DMTNRG7 MI TTEX248 DMTNRG7 MN Dopamine D2 receptor (D2R) DMTNRG7 MT DTT DMTNRG7 MA Inhibitor DMTNRG7 RN Dopamine/serotonin receptor ligands. 9. Oxygen-containing midsized heterocyclic ring systems and nonrigidized analogues. A step toward dopamine D5 ... J Med Chem. 2004 Aug 12;47(17):4155-8. DMTNRG7 RU https://pubmed.ncbi.nlm.nih.gov/15293986 DMTNRG7 DI DMTNRG7 DMTNRG7 DN 1-[2-(2-Benzyl-phenoxy)-ethyl]-piperidine DMTNRG7 MI TT4C8EA DMTNRG7 MN Dopamine D3 receptor (D3R) DMTNRG7 MT DTT DMTNRG7 MA Inhibitor DMTNRG7 RN Dopamine/serotonin receptor ligands. 9. Oxygen-containing midsized heterocyclic ring systems and nonrigidized analogues. A step toward dopamine D5 ... J Med Chem. 2004 Aug 12;47(17):4155-8. DMTNRG7 RU https://pubmed.ncbi.nlm.nih.gov/15293986 DMTNRG7 DI DMTNRG7 DMTNRG7 DN 1-[2-(2-Benzyl-phenoxy)-ethyl]-piperidine DMTNRG7 MI TTE0A2F DMTNRG7 MN Dopamine D4 receptor (D4R) DMTNRG7 MT DTT DMTNRG7 MA Inhibitor DMTNRG7 RN Dopamine/serotonin receptor ligands. 9. Oxygen-containing midsized heterocyclic ring systems and nonrigidized analogues. A step toward dopamine D5 ... J Med Chem. 2004 Aug 12;47(17):4155-8. DMTNRG7 RU https://pubmed.ncbi.nlm.nih.gov/15293986 DMTNRG7 DI DMTNRG7 DMTNRG7 DN 1-[2-(2-Benzyl-phenoxy)-ethyl]-piperidine DMTNRG7 MI TTS2PH3 DMTNRG7 MN Dopamine D5 receptor (D5R) DMTNRG7 MT DTT DMTNRG7 MA Inhibitor DMTNRG7 RN Dopamine/serotonin receptor ligands. 9. Oxygen-containing midsized heterocyclic ring systems and nonrigidized analogues. A step toward dopamine D5 ... J Med Chem. 2004 Aug 12;47(17):4155-8. DMTNRG7 RU https://pubmed.ncbi.nlm.nih.gov/15293986 DMLSU30 DI DMLSU30 DMLSU30 DN 1-[2-(2-Benzyl-phenoxy)-ethyl]-pyrrolidine DMLSU30 MI TTZFYLI DMLSU30 MN Dopamine D1 receptor (D1R) DMLSU30 MT DTT DMLSU30 MA Inhibitor DMLSU30 RN Dopamine/serotonin receptor ligands. 9. Oxygen-containing midsized heterocyclic ring systems and nonrigidized analogues. A step toward dopamine D5 ... J Med Chem. 2004 Aug 12;47(17):4155-8. DMLSU30 RU https://pubmed.ncbi.nlm.nih.gov/15293986 DMLSU30 DI DMLSU30 DMLSU30 DN 1-[2-(2-Benzyl-phenoxy)-ethyl]-pyrrolidine DMLSU30 MI TT4C8EA DMLSU30 MN Dopamine D3 receptor (D3R) DMLSU30 MT DTT DMLSU30 MA Inhibitor DMLSU30 RN Dopamine/serotonin receptor ligands. 9. Oxygen-containing midsized heterocyclic ring systems and nonrigidized analogues. A step toward dopamine D5 ... J Med Chem. 2004 Aug 12;47(17):4155-8. DMLSU30 RU https://pubmed.ncbi.nlm.nih.gov/15293986 DMLSU30 DI DMLSU30 DMLSU30 DN 1-[2-(2-Benzyl-phenoxy)-ethyl]-pyrrolidine DMLSU30 MI TTE0A2F DMLSU30 MN Dopamine D4 receptor (D4R) DMLSU30 MT DTT DMLSU30 MA Inhibitor DMLSU30 RN Dopamine/serotonin receptor ligands. 9. Oxygen-containing midsized heterocyclic ring systems and nonrigidized analogues. A step toward dopamine D5 ... J Med Chem. 2004 Aug 12;47(17):4155-8. DMLSU30 RU https://pubmed.ncbi.nlm.nih.gov/15293986 DMLSU30 DI DMLSU30 DMLSU30 DN 1-[2-(2-Benzyl-phenoxy)-ethyl]-pyrrolidine DMLSU30 MI TTS2PH3 DMLSU30 MN Dopamine D5 receptor (D5R) DMLSU30 MT DTT DMLSU30 MA Inhibitor DMLSU30 RN Dopamine/serotonin receptor ligands. 9. Oxygen-containing midsized heterocyclic ring systems and nonrigidized analogues. A step toward dopamine D5 ... J Med Chem. 2004 Aug 12;47(17):4155-8. DMLSU30 RU https://pubmed.ncbi.nlm.nih.gov/15293986 DMDZA83 DI DMDZA83 DMDZA83 DN 1-[2-(2-triphenylmethoxyethoxy)ethyl]thymine DMDZA83 MI TTP3QRF DMDZA83 MN Thymidine kinase 1 (TK1) DMDZA83 MT DTT DMDZA83 MA Inhibitor DMDZA83 RN N1-substituted thymine derivatives as mitochondrial thymidine kinase (TK-2) inhibitors. J Med Chem. 2006 Dec 28;49(26):7766-73. DMDZA83 RU https://pubmed.ncbi.nlm.nih.gov/17181158 DM98F0U DI DM98F0U DM98F0U DN 1-[2-(trityloxy)ethoxymethyl]uracil DM98F0U MI TTY8KJS DM98F0U MN Bacterial Deoxyuridine triphosphate nucleotidohydrolase (Bact dut) DM98F0U MT DTT DM98F0U MA Inhibitor DM98F0U RN Acyclic nucleoside analogues as inhibitors of Plasmodium falciparum dUTPase. J Med Chem. 2006 Jul 13;49(14):4183-95. DM98F0U RU https://pubmed.ncbi.nlm.nih.gov/16821778 DMD2NXL DI DMD2NXL DMD2NXL DN 1-[3-(2-Benzyl-phenoxy)-propyl]-pyrrolidine DMD2NXL MI TTZFYLI DMD2NXL MN Dopamine D1 receptor (D1R) DMD2NXL MT DTT DMD2NXL MA Inhibitor DMD2NXL RN Dopamine/serotonin receptor ligands. 9. Oxygen-containing midsized heterocyclic ring systems and nonrigidized analogues. A step toward dopamine D5 ... J Med Chem. 2004 Aug 12;47(17):4155-8. DMD2NXL RU https://pubmed.ncbi.nlm.nih.gov/15293986 DMD2NXL DI DMD2NXL DMD2NXL DN 1-[3-(2-Benzyl-phenoxy)-propyl]-pyrrolidine DMD2NXL MI TTEX248 DMD2NXL MN Dopamine D2 receptor (D2R) DMD2NXL MT DTT DMD2NXL MA Inhibitor DMD2NXL RN Dopamine/serotonin receptor ligands. 9. Oxygen-containing midsized heterocyclic ring systems and nonrigidized analogues. A step toward dopamine D5 ... J Med Chem. 2004 Aug 12;47(17):4155-8. DMD2NXL RU https://pubmed.ncbi.nlm.nih.gov/15293986 DMD2NXL DI DMD2NXL DMD2NXL DN 1-[3-(2-Benzyl-phenoxy)-propyl]-pyrrolidine DMD2NXL MI TT4C8EA DMD2NXL MN Dopamine D3 receptor (D3R) DMD2NXL MT DTT DMD2NXL MA Inhibitor DMD2NXL RN Dopamine/serotonin receptor ligands. 9. Oxygen-containing midsized heterocyclic ring systems and nonrigidized analogues. A step toward dopamine D5 ... J Med Chem. 2004 Aug 12;47(17):4155-8. DMD2NXL RU https://pubmed.ncbi.nlm.nih.gov/15293986 DMD2NXL DI DMD2NXL DMD2NXL DN 1-[3-(2-Benzyl-phenoxy)-propyl]-pyrrolidine DMD2NXL MI TTE0A2F DMD2NXL MN Dopamine D4 receptor (D4R) DMD2NXL MT DTT DMD2NXL MA Inhibitor DMD2NXL RN Dopamine/serotonin receptor ligands. 9. Oxygen-containing midsized heterocyclic ring systems and nonrigidized analogues. A step toward dopamine D5 ... J Med Chem. 2004 Aug 12;47(17):4155-8. DMD2NXL RU https://pubmed.ncbi.nlm.nih.gov/15293986 DMD2NXL DI DMD2NXL DMD2NXL DN 1-[3-(2-Benzyl-phenoxy)-propyl]-pyrrolidine DMD2NXL MI TTS2PH3 DMD2NXL MN Dopamine D5 receptor (D5R) DMD2NXL MT DTT DMD2NXL MA Inhibitor DMD2NXL RN Dopamine/serotonin receptor ligands. 9. Oxygen-containing midsized heterocyclic ring systems and nonrigidized analogues. A step toward dopamine D5 ... J Med Chem. 2004 Aug 12;47(17):4155-8. DMD2NXL RU https://pubmed.ncbi.nlm.nih.gov/15293986 DMLRS8I DI DMLRS8I DMLRS8I DN 1-[3-(3-biphenyl)-(1,2,4-triazol-4-yl) ]-3-phenol DMLRS8I MI TT27RFC DMLRS8I MN Opioid receptor delta (OPRD1) DMLRS8I MT DTT DMLRS8I MA Inhibitor DMLRS8I RN Discovery of novel triazole-based opioid receptor antagonists. J Med Chem. 2006 Jul 13;49(14):4044-7. DMLRS8I RU https://pubmed.ncbi.nlm.nih.gov/16821764 DMLRS8I DI DMLRS8I DMLRS8I DN 1-[3-(3-biphenyl)-(1,2,4-triazol-4-yl) ]-3-phenol DMLRS8I MI TTKWM86 DMLRS8I MN Opioid receptor mu (MOP) DMLRS8I MT DTT DMLRS8I MA Inhibitor DMLRS8I RN Discovery of novel triazole-based opioid receptor antagonists. J Med Chem. 2006 Jul 13;49(14):4044-7. DMLRS8I RU https://pubmed.ncbi.nlm.nih.gov/16821764 DMB1NF0 DI DMB1NF0 DMB1NF0 DN 1-[3-(4-biphenyl)-(1,2,4-triazol-4-yl) ]-3-phenol DMB1NF0 MI TT27RFC DMB1NF0 MN Opioid receptor delta (OPRD1) DMB1NF0 MT DTT DMB1NF0 MA Inhibitor DMB1NF0 RN Discovery of novel triazole-based opioid receptor antagonists. J Med Chem. 2006 Jul 13;49(14):4044-7. DMB1NF0 RU https://pubmed.ncbi.nlm.nih.gov/16821764 DMB1NF0 DI DMB1NF0 DMB1NF0 DN 1-[3-(4-biphenyl)-(1,2,4-triazol-4-yl) ]-3-phenol DMB1NF0 MI TTKWM86 DMB1NF0 MN Opioid receptor mu (MOP) DMB1NF0 MT DTT DMB1NF0 MA Inhibitor DMB1NF0 RN Discovery of novel triazole-based opioid receptor antagonists. J Med Chem. 2006 Jul 13;49(14):4044-7. DMB1NF0 RU https://pubmed.ncbi.nlm.nih.gov/16821764 DMS192I DI DMS192I DMS192I DN 1-[3-(Methylsulfonyl)phenyl]-4-propylpiperazine DMS192I MI TTEX248 DMS192I MN Dopamine D2 receptor (D2R) DMS192I MT DTT DMS192I MA Inhibitor DMS192I RN Synthesis and evaluation of a set of 4-phenylpiperidines and 4-phenylpiperazines as D2 receptor ligands and the discovery of the dopaminergic stabi... J Med Chem. 2010 Mar 25;53(6):2510-20. DMS192I RU https://pubmed.ncbi.nlm.nih.gov/20155917 DME1R96 DI DME1R96 DME1R96 DN 1-[4-(2-oxo-2-phenylethyl)phenyl]guanidine DME1R96 MI TTGY7WI DME1R96 MN Urokinase-type plasminogen activator (PLAU) DME1R96 MT DTT DME1R96 MA Inhibitor DME1R96 RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DME1R96 RU https://pubmed.ncbi.nlm.nih.gov/10592235 DM0I2RH DI DM0I2RH DM0I2RH DN 1-[4-(4-Iodophenoxy)phenyl]piperazine DM0I2RH MI TTXZEAJ DM0I2RH MN Leukotriene A-4 hydrolase (LTA4H) DM0I2RH MT DTT DM0I2RH MA Inhibitor DM0I2RH RN Discovery of 4-[(2S)-2-{[4-(4-chlorophenoxy)phenoxy]methyl}-1-pyrrolidinyl]butanoic acid (DG-051) as a novel leukotriene A4 hydrolase inhibitor of ... J Med Chem. 2010 Jan 28;53(2):573-85. DM0I2RH RU https://pubmed.ncbi.nlm.nih.gov/19950900 DM4F1GJ DI DM4F1GJ DM4F1GJ DN 1-[4-(Benzothiazol-2-yloxy)benzyl]piperidin-4-ol DM4F1GJ MI TTXZEAJ DM4F1GJ MN Leukotriene A-4 hydrolase (LTA4H) DM4F1GJ MT DTT DM4F1GJ MA Inhibitor DM4F1GJ RN Identification of a potent, selective, and orally active leukotriene a4 hydrolase inhibitor with anti-inflammatory activity. J Med Chem. 2008 Jul 24;51(14):4150-69. DM4F1GJ RU https://pubmed.ncbi.nlm.nih.gov/18588282 DMHXAMR DI DMHXAMR DMHXAMR DN 1-[4-hydroxy-3-(tritylaminomethyl)butyl]uracil DMHXAMR MI TTY8KJS DMHXAMR MN Bacterial Deoxyuridine triphosphate nucleotidohydrolase (Bact dut) DMHXAMR MT DTT DMHXAMR MA Inhibitor DMHXAMR RN Acyclic nucleoside analogues as inhibitors of Plasmodium falciparum dUTPase. J Med Chem. 2006 Jul 13;49(14):4183-95. DMHXAMR RU https://pubmed.ncbi.nlm.nih.gov/16821778 DM8NMAV DI DM8NMAV DM8NMAV DN 1-[5-(4-Chlorophenyl)-2-furoyl]piperazine DM8NMAV MI TTZOVE0 DM8NMAV MN Voltage-gated sodium channel alpha Nav1.5 (SCN5A) DM8NMAV MT DTT DM8NMAV MA Inhibitor DM8NMAV RN Discovery of potent furan piperazine sodium channel blockers for treatment of neuropathic pain. Bioorg Med Chem. 2008 Jun 15;16(12):6379-86. DM8NMAV RU https://pubmed.ncbi.nlm.nih.gov/18501613 DM8NMAV DI DM8NMAV DM8NMAV DN 1-[5-(4-Chlorophenyl)-2-furoyl]piperazine DM8NMAV MI TT90XZ8 DM8NMAV MN Voltage-gated sodium channel alpha Nav1.8 (SCN10A) DM8NMAV MT DTT DM8NMAV MA Inhibitor DM8NMAV RN Discovery of potent furan piperazine sodium channel blockers for treatment of neuropathic pain. Bioorg Med Chem. 2008 Jun 15;16(12):6379-86. DM8NMAV RU https://pubmed.ncbi.nlm.nih.gov/18501613 DMFHBJM DI DMFHBJM DMFHBJM DN 1-[5-(triphenylmethoxy)pentyl]thymine DMFHBJM MI TTP3QRF DMFHBJM MN Thymidine kinase 1 (TK1) DMFHBJM MT DTT DMFHBJM MA Inhibitor DMFHBJM RN N1-substituted thymine derivatives as mitochondrial thymidine kinase (TK-2) inhibitors. J Med Chem. 2006 Dec 28;49(26):7766-73. DMFHBJM RU https://pubmed.ncbi.nlm.nih.gov/17181158 DMFHBJM DI DMFHBJM DMFHBJM DN 1-[5-(triphenylmethoxy)pentyl]thymine DMFHBJM MI TT7KNZQ DMFHBJM MN Thymidine kinase 2 (Mt-TK2) DMFHBJM MT DTT DMFHBJM MA Inhibitor DMFHBJM RN N1-substituted thymine derivatives as mitochondrial thymidine kinase (TK-2) inhibitors. J Med Chem. 2006 Dec 28;49(26):7766-73. DMFHBJM RU https://pubmed.ncbi.nlm.nih.gov/17181158 DM5NVHO DI DM5NVHO DM5NVHO DN 1-[6-(triphenylmethoxy)hexyl]thymine DM5NVHO MI TTP3QRF DM5NVHO MN Thymidine kinase 1 (TK1) DM5NVHO MT DTT DM5NVHO MA Inhibitor DM5NVHO RN N1-substituted thymine derivatives as mitochondrial thymidine kinase (TK-2) inhibitors. J Med Chem. 2006 Dec 28;49(26):7766-73. DM5NVHO RU https://pubmed.ncbi.nlm.nih.gov/17181158 DM5NVHO DI DM5NVHO DM5NVHO DN 1-[6-(triphenylmethoxy)hexyl]thymine DM5NVHO MI TT7KNZQ DM5NVHO MN Thymidine kinase 2 (Mt-TK2) DM5NVHO MT DTT DM5NVHO MA Inhibitor DM5NVHO RN N1-substituted thymine derivatives as mitochondrial thymidine kinase (TK-2) inhibitors. J Med Chem. 2006 Dec 28;49(26):7766-73. DM5NVHO RU https://pubmed.ncbi.nlm.nih.gov/17181158 DMQ05F2 DI DMQ05F2 DMQ05F2 DN 1-[7-(triphenylmethoxy)heptyl]thymine DMQ05F2 MI TTP3QRF DMQ05F2 MN Thymidine kinase 1 (TK1) DMQ05F2 MT DTT DMQ05F2 MA Inhibitor DMQ05F2 RN N1-substituted thymine derivatives as mitochondrial thymidine kinase (TK-2) inhibitors. J Med Chem. 2006 Dec 28;49(26):7766-73. DMQ05F2 RU https://pubmed.ncbi.nlm.nih.gov/17181158 DM13D4E DI DM13D4E DM13D4E DN 1-[bis(4-bromophenyl)methyl]-3-phenylthiourea DM13D4E MI TT6OEDT DM13D4E MN Cannabinoid receptor 1 (CB1) DM13D4E MT DTT DM13D4E MA Inhibitor DM13D4E RN 1-Benzhydryl-3-phenylurea and 1-benzhydryl-3-phenylthiourea derivatives: new templates among the CB1 cannabinoid receptor inverse agonists. J Med Chem. 2005 Nov 17;48(23):7486-90. DM13D4E RU https://pubmed.ncbi.nlm.nih.gov/16279809 DMN2LHM DI DMN2LHM DMN2LHM DN 1-[bis(4-chlorophenyl)methyl]-3-(4-chlorophenyl)- DMN2LHM MI TT6OEDT DMN2LHM MN Cannabinoid receptor 1 (CB1) DMN2LHM MT DTT DMN2LHM MA Inhibitor DMN2LHM RN 1-Benzhydryl-3-phenylurea and 1-benzhydryl-3-phenylthiourea derivatives: new templates among the CB1 cannabinoid receptor inverse agonists. J Med Chem. 2005 Nov 17;48(23):7486-90. DMN2LHM RU https://pubmed.ncbi.nlm.nih.gov/16279809 DMFMR2N DI DMFMR2N DMFMR2N DN 1-[bis(4-chlorophenyl)methyl]-3-phenylthiourea DMFMR2N MI TT6OEDT DMFMR2N MN Cannabinoid receptor 1 (CB1) DMFMR2N MT DTT DMFMR2N MA Inhibitor DMFMR2N RN 1-Benzhydryl-3-phenylurea and 1-benzhydryl-3-phenylthiourea derivatives: new templates among the CB1 cannabinoid receptor inverse agonists. J Med Chem. 2005 Nov 17;48(23):7486-90. DMFMR2N RU https://pubmed.ncbi.nlm.nih.gov/16279809 DMJT7VI DI DMJT7VI DMJT7VI DN 1-[bis(4-iodophenyl)methyl]-3-(4-bromophenyl)urea DMJT7VI MI TT6OEDT DMJT7VI MN Cannabinoid receptor 1 (CB1) DMJT7VI MT DTT DMJT7VI MA Inhibitor DMJT7VI RN 1-Benzhydryl-3-phenylurea and 1-benzhydryl-3-phenylthiourea derivatives: new templates among the CB1 cannabinoid receptor inverse agonists. J Med Chem. 2005 Nov 17;48(23):7486-90. DMJT7VI RU https://pubmed.ncbi.nlm.nih.gov/16279809 DML745Y DI DML745Y DML745Y DN 10,10-difluoro TXA2 DML745Y MI TT2O84V DML745Y MN Thromboxane A2 receptor (TBXA2R) DML745Y MT DTT DML745Y MA Agonist DML745Y RN Difluorothromboxane A2 and stereoisomers: stable derivatives of thromboxane A2 with differential effects on platelets and blood vessels. Proc Natl Acad Sci U S A. 1989 Jul;86(14):5600-4. DML745Y RU https://pubmed.ncbi.nlm.nih.gov/2748606 DMS5ICY DI DMS5ICY DMS5ICY DN 10,11-dihydro-5H-dibenzo[b,f]azepine DMS5ICY MI TTPC4TU DMS5ICY MN 5-HT 3A receptor (HTR3A) DMS5ICY MT DTT DMS5ICY MA Inhibitor DMS5ICY RN Molecular properties of psychopharmacological drugs determining non-competitive inhibition of 5-HT3A receptors. Eur J Med Chem. 2009 Jun;44(6):2667-72. DMS5ICY RU https://pubmed.ncbi.nlm.nih.gov/19144451 DM5BUXZ DI DM5BUXZ DM5BUXZ DN 10-Acetyl-1,8-dihydroxy-10H-anthracen-9-one DM5BUXZ MI TT2J34L DM5BUXZ MN Arachidonate 5-lipoxygenase (5-LOX) DM5BUXZ MT DTT DM5BUXZ MA Inhibitor DM5BUXZ RN Simple analogues of anthralin: unusual specificity of structure and antiproliferative activity. J Med Chem. 1997 Nov 7;40(23):3773-80. DM5BUXZ RU https://pubmed.ncbi.nlm.nih.gov/9371243 DM1JLUV DI DM1JLUV DM1JLUV DN 10-Allyl-10H-dibenzo[b,f][1,4]oxazepin-11-one DM1JLUV MI TT84ETX DM1JLUV MN Human immunodeficiency virus Reverse transcriptase (HIV RT) DM1JLUV MT DTT DM1JLUV MA Inhibitor DM1JLUV RN Novel non-nucleoside inhibitors of HIV-1 reverse transcriptase. 2. Tricyclic pyridobenzoxazepinones and dibenzoxazepinones. J Med Chem. 1992 May 15;35(10):1887-97. DM1JLUV RU https://pubmed.ncbi.nlm.nih.gov/1375293 DM4M2VU DI DM4M2VU DM4M2VU DN 10-Benzoyl-1,8-dihydroxy-10H-anthracen-9-one DM4M2VU MI TT2J34L DM4M2VU MN Arachidonate 5-lipoxygenase (5-LOX) DM4M2VU MT DTT DM4M2VU MA Inhibitor DM4M2VU RN Simple analogues of anthralin: unusual specificity of structure and antiproliferative activity. J Med Chem. 1997 Nov 7;40(23):3773-80. DM4M2VU RU https://pubmed.ncbi.nlm.nih.gov/9371243 DMQOUJ7 DI DMQOUJ7 DMQOUJ7 DN 10-CF3C(OH)2-DDACTHF DMQOUJ7 MI TTEXB9Z DMQOUJ7 MN Glycinamide ribonucleotide formyltransferase (GART) DMQOUJ7 MT DTT DMQOUJ7 MA Inhibitor DMQOUJ7 RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMQOUJ7 RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMDQ7Z9 DI DMDQ7Z9 DMDQ7Z9 DN 10-EPI-8-DEOXY-CUMAMBRIN B DMDQ7Z9 MI TTSZLWK DMDQ7Z9 MN Aromatase (CYP19A1) DMDQ7Z9 MT DTT DMDQ7Z9 MA Inhibitor DMDQ7Z9 RN Pharmacophore modeling strategies for the development of novel nonsteroidal inhibitors of human aromatase (CYP19). Bioorg Med Chem Lett. 2010 May 15;20(10):3050-64. DMDQ7Z9 RU https://pubmed.ncbi.nlm.nih.gov/20413308 DMGT82V DI DMGT82V DMGT82V DN 10-Ethyl-10H-dibenzo[b,f][1,4]oxazepin-11-one DMGT82V MI TT84ETX DMGT82V MN Human immunodeficiency virus Reverse transcriptase (HIV RT) DMGT82V MT DTT DMGT82V MA Inhibitor DMGT82V RN Novel non-nucleoside inhibitors of HIV-1 reverse transcriptase. 2. Tricyclic pyridobenzoxazepinones and dibenzoxazepinones. J Med Chem. 1992 May 15;35(10):1887-97. DMGT82V RU https://pubmed.ncbi.nlm.nih.gov/1375293 DMEBHML DI DMEBHML DMEBHML DN 10-Formyl-5,8,10-Trideazafolic Acid DMEBHML MI TTEXB9Z DMEBHML MN Glycinamide ribonucleotide formyltransferase (GART) DMEBHML MT DTT DMEBHML MA Inhibitor DMEBHML RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMEBHML RU https://pubmed.ncbi.nlm.nih.gov/17139284 DM4R7X8 DI DM4R7X8 DM4R7X8 DN 10-hydroxy-18-methoxybetaenone DM4R7X8 MI TT0PG8F DM4R7X8 MN Cyclin-dependent kinase 4 (CDK4) DM4R7X8 MT DTT DM4R7X8 MA Inhibitor DM4R7X8 RN Anthraquinones and betaenone derivatives from the sponge-associated fungus Microsphaeropsis species: novel inhibitors of protein kinases. J Nat Prod. 2000 Jun;63(6):739-45. DM4R7X8 RU https://pubmed.ncbi.nlm.nih.gov/10869191 DM4R7X8 DI DM4R7X8 DM4R7X8 DN 10-hydroxy-18-methoxybetaenone DM4R7X8 MI TTGKNB4 DM4R7X8 MN Epidermal growth factor receptor (EGFR) DM4R7X8 MT DTT DM4R7X8 MA Inhibitor DM4R7X8 RN Anthraquinones and betaenone derivatives from the sponge-associated fungus Microsphaeropsis species: novel inhibitors of protein kinases. J Nat Prod. 2000 Jun;63(6):739-45. DM4R7X8 RU https://pubmed.ncbi.nlm.nih.gov/10869191 DM9WLN4 DI DM9WLN4 DM9WLN4 DN 10-hydroxycamptothecin DM9WLN4 MI TTGTQHC DM9WLN4 MN DNA topoisomerase I (TOP1) DM9WLN4 MT DTT DM9WLN4 MA Inhibitor DM9WLN4 RN Upregulation of p21WAF1/CIP1 in human breast cancer cell lines MCF-7 and MDA-MB-468 undergoing apoptosis induced by natural product anticancer drugs 10-hydroxycamptothecin and camptothecin through p53-dependent and independent pathways. Int J Oncol. 1998 Apr;12(4):793-804. DM9WLN4 RU https://pubmed.ncbi.nlm.nih.gov/9499438 DM9WLN4 DI DM9WLN4 DM9WLN4 DN 10-hydroxycamptothecin DM9WLN4 MI DTCSGPB DM9WLN4 MN Multidrug resistance-associated protein 4 (ABCC4) DM9WLN4 MT DTP DM9WLN4 MA Substrate DM9WLN4 RN Human intestinal transporter database: QSAR modeling and virtual profiling of drug uptake, efflux and interactions. Pharm Res. 2013 Apr;30(4):996-1007. DM9WLN4 RU https://doi.org/10.1007/s11095-012-0935-x DM5H73W DI DM5H73W DM5H73W DN 10-Hydroxy-infractopicrin DM5H73W MI TT1RS9F DM5H73W MN Acetylcholinesterase (AChE) DM5H73W MT DTT DM5H73W MA Inhibitor DM5H73W RN Acetylcholinesterase inhibitors from the toadstool Cortinarius infractus. Bioorg Med Chem. 2010 Mar 15;18(6):2173-2177. DM5H73W RU https://pubmed.ncbi.nlm.nih.gov/20176490 DMCXA1Y DI DMCXA1Y DMCXA1Y DN 10-Isopropyl-10H-dibenzo[b,f][1,4]oxazepin-11-one DMCXA1Y MI TT84ETX DMCXA1Y MN Human immunodeficiency virus Reverse transcriptase (HIV RT) DMCXA1Y MT DTT DMCXA1Y MA Inhibitor DMCXA1Y RN Novel non-nucleoside inhibitors of HIV-1 reverse transcriptase. 2. Tricyclic pyridobenzoxazepinones and dibenzoxazepinones. J Med Chem. 1992 May 15;35(10):1887-97. DMCXA1Y RU https://pubmed.ncbi.nlm.nih.gov/1375293 DM2H6KD DI DM2H6KD DM2H6KD DN 10-methoxy-ginkgolide C DM2H6KD MI TTZ8EM9 DM2H6KD MN Glycine receptor (GlyR) DM2H6KD MT DTT DM2H6KD MA Inhibitor DM2H6KD RN Probing the pharmacophore of ginkgolides as glycine receptor antagonists. J Med Chem. 2007 Apr 5;50(7):1610-7. DM2H6KD RU https://pubmed.ncbi.nlm.nih.gov/17352465 DM2H6KD DI DM2H6KD DM2H6KD DN 10-methoxy-ginkgolide C DM2H6KD MI TTF45NW DM2H6KD MN Strychnine-binding glycine receptor (GLRA1) DM2H6KD MT DTT DM2H6KD MA Inhibitor DM2H6KD RN Probing the pharmacophore of ginkgolides as glycine receptor antagonists. J Med Chem. 2007 Apr 5;50(7):1610-7. DM2H6KD RU https://pubmed.ncbi.nlm.nih.gov/17352465 DMJW25X DI DMJW25X DMJW25X DN 10-methoxy-N(1)-methylburnamine-17-O-veratrate DMJW25X MI TTF8JAT DMJW25X MN SLC5A2 messenger RNA (SLC5A2 mRNA) DMJW25X MT DTT DMJW25X MA Inhibitor DMJW25X RN Alstiphyllanines E-H, picraline and ajmaline-type alkaloids from Alstonia macrophylla inhibiting sodium glucose cotransporter. Bioorg Med Chem. 2010 Mar 15;18(6):2152-2158. DMJW25X RU https://pubmed.ncbi.nlm.nih.gov/20189404 DMJW25X DI DMJW25X DMJW25X DN 10-methoxy-N(1)-methylburnamine-17-O-veratrate DMJW25X MI TT2UE56 DMJW25X MN Sodium/glucose cotransporter 1 (SGLT1) DMJW25X MT DTT DMJW25X MA Inhibitor DMJW25X RN Alstiphyllanines E-H, picraline and ajmaline-type alkaloids from Alstonia macrophylla inhibiting sodium glucose cotransporter. Bioorg Med Chem. 2010 Mar 15;18(6):2152-2158. DMJW25X RU https://pubmed.ncbi.nlm.nih.gov/20189404 DMM9GEA DI DMM9GEA DMM9GEA DN 10-OBn-7alpha-F-gingkolide B DMM9GEA MI TTQL5VC DMM9GEA MN Platelet-activating factor receptor (PTAFR) DMM9GEA MT DTT DMM9GEA MA Antagonist DMM9GEA RN Preparation of 7-substituted ginkgolide derivatives: potent platelet activating factor (PAF) receptor antagonists. J Med Chem. 2003 Feb 13;46(4):601-8. DMM9GEA RU https://pubmed.ncbi.nlm.nih.gov/12570381 DMAM5WJ DI DMAM5WJ DMAM5WJ DN 10-OBn-epi-ginkgolide C DMAM5WJ MI TTQL5VC DMAM5WJ MN Platelet-activating factor receptor (PTAFR) DMAM5WJ MT DTT DMAM5WJ MA Antagonist DMAM5WJ RN Preparation of 7-substituted ginkgolide derivatives: potent platelet activating factor (PAF) receptor antagonists. J Med Chem. 2003 Feb 13;46(4):601-8. DMAM5WJ RU https://pubmed.ncbi.nlm.nih.gov/12570381 DMS0I5V DI DMS0I5V DMS0I5V DN 10-OBn-ginkgolide B DMS0I5V MI TTQL5VC DMS0I5V MN Platelet-activating factor receptor (PTAFR) DMS0I5V MT DTT DMS0I5V MA Antagonist DMS0I5V RN Preparation of 7-substituted ginkgolide derivatives: potent platelet activating factor (PAF) receptor antagonists. J Med Chem. 2003 Feb 13;46(4):601-8. DMS0I5V RU https://pubmed.ncbi.nlm.nih.gov/12570381 DMOXKLH DI DMOXKLH DMOXKLH DN 10-OBn-ginkgolide C DMOXKLH MI TTQL5VC DMOXKLH MN Platelet-activating factor receptor (PTAFR) DMOXKLH MT DTT DMOXKLH MA Antagonist DMOXKLH RN Preparation of 7-substituted ginkgolide derivatives: potent platelet activating factor (PAF) receptor antagonists. J Med Chem. 2003 Feb 13;46(4):601-8. DMOXKLH RU https://pubmed.ncbi.nlm.nih.gov/12570381 DMR3A5N DI DMR3A5N DMR3A5N DN 10-Propargyl-5,8-Dideazafolic Acid DMR3A5N MI TTU6BFZ DMR3A5N MN Candida Thymidylate synthase (Candi TMP1) DMR3A5N MT DTT DMR3A5N MA Inhibitor DMR3A5N RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMR3A5N RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMR3A5N DI DMR3A5N DMR3A5N DN 10-Propargyl-5,8-Dideazafolic Acid DMR3A5N MI TTJLP0R DMR3A5N MN Quinone reductase 2 (NQO2) DMR3A5N MT DTT DMR3A5N MA Inhibitor DMR3A5N RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMR3A5N RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMD1258 DI DMD1258 DMD1258 DN 10-Propyl-10H-dibenzo[b,f][1,4]oxazepin-11-one DMD1258 MI TT84ETX DMD1258 MN Human immunodeficiency virus Reverse transcriptase (HIV RT) DMD1258 MT DTT DMD1258 MA Inhibitor DMD1258 RN Novel non-nucleoside inhibitors of HIV-1 reverse transcriptase. 2. Tricyclic pyridobenzoxazepinones and dibenzoxazepinones. J Med Chem. 1992 May 15;35(10):1887-97. DMD1258 RU https://pubmed.ncbi.nlm.nih.gov/1375293 DMZ3N8A DI DMZ3N8A DMZ3N8A DN 10-Propyl-10H-dibenzo[b,f][1,4]thiazepin-11-one DMZ3N8A MI TT84ETX DMZ3N8A MN Human immunodeficiency virus Reverse transcriptase (HIV RT) DMZ3N8A MT DTT DMZ3N8A MA Inhibitor DMZ3N8A RN Novel non-nucleoside inhibitors of HIV-1 reverse transcriptase. 2. Tricyclic pyridobenzoxazepinones and dibenzoxazepinones. J Med Chem. 1992 May 15;35(10):1887-97. DMZ3N8A RU https://pubmed.ncbi.nlm.nih.gov/1375293 DM8XRCT DI DM8XRCT DM8XRCT DN 10R-hydroxylobel-7-ene DM8XRCT MI TTVBI8W DM8XRCT MN Dopamine transporter (DAT) DM8XRCT MT DTT DM8XRCT MA Inhibitor DM8XRCT RN Des-keto lobeline analogs with increased potency and selectivity at dopamine and serotonin transporters. Bioorg Med Chem Lett. 2006 Oct 1;16(19):5018-21. DM8XRCT RU https://pubmed.ncbi.nlm.nih.gov/16905316 DM8XRCT DI DM8XRCT DM8XRCT DN 10R-hydroxylobel-7-ene DM8XRCT MI TT3ROYC DM8XRCT MN Serotonin transporter (SERT) DM8XRCT MT DTT DM8XRCT MA Inhibitor DM8XRCT RN Des-keto lobeline analogs with increased potency and selectivity at dopamine and serotonin transporters. Bioorg Med Chem Lett. 2006 Oct 1;16(19):5018-21. DM8XRCT RU https://pubmed.ncbi.nlm.nih.gov/16905316 DMN93QT DI DMN93QT DMN93QT DN 10R-hydroxylobelane DMN93QT MI TTVBI8W DMN93QT MN Dopamine transporter (DAT) DMN93QT MT DTT DMN93QT MA Inhibitor DMN93QT RN Des-keto lobeline analogs with increased potency and selectivity at dopamine and serotonin transporters. Bioorg Med Chem Lett. 2006 Oct 1;16(19):5018-21. DMN93QT RU https://pubmed.ncbi.nlm.nih.gov/16905316 DMN93QT DI DMN93QT DMN93QT DN 10R-hydroxylobelane DMN93QT MI TT3ROYC DMN93QT MN Serotonin transporter (SERT) DMN93QT MT DTT DMN93QT MA Inhibitor DMN93QT RN Des-keto lobeline analogs with increased potency and selectivity at dopamine and serotonin transporters. Bioorg Med Chem Lett. 2006 Oct 1;16(19):5018-21. DMN93QT RU https://pubmed.ncbi.nlm.nih.gov/16905316 DMN1YQ6 DI DMN1YQ6 DMN1YQ6 DN 10S-hydroxylobel-7-ene DMN1YQ6 MI TTVBI8W DMN1YQ6 MN Dopamine transporter (DAT) DMN1YQ6 MT DTT DMN1YQ6 MA Inhibitor DMN1YQ6 RN Des-keto lobeline analogs with increased potency and selectivity at dopamine and serotonin transporters. Bioorg Med Chem Lett. 2006 Oct 1;16(19):5018-21. DMN1YQ6 RU https://pubmed.ncbi.nlm.nih.gov/16905316 DMN1YQ6 DI DMN1YQ6 DMN1YQ6 DN 10S-hydroxylobel-7-ene DMN1YQ6 MI TT3ROYC DMN1YQ6 MN Serotonin transporter (SERT) DMN1YQ6 MT DTT DMN1YQ6 MA Inhibitor DMN1YQ6 RN Des-keto lobeline analogs with increased potency and selectivity at dopamine and serotonin transporters. Bioorg Med Chem Lett. 2006 Oct 1;16(19):5018-21. DMN1YQ6 RU https://pubmed.ncbi.nlm.nih.gov/16905316 DM54AKV DI DM54AKV DM54AKV DN 10S-hydroxylobelane DM54AKV MI TTVBI8W DM54AKV MN Dopamine transporter (DAT) DM54AKV MT DTT DM54AKV MA Inhibitor DM54AKV RN Des-keto lobeline analogs with increased potency and selectivity at dopamine and serotonin transporters. Bioorg Med Chem Lett. 2006 Oct 1;16(19):5018-21. DM54AKV RU https://pubmed.ncbi.nlm.nih.gov/16905316 DM54AKV DI DM54AKV DM54AKV DN 10S-hydroxylobelane DM54AKV MI TT3ROYC DM54AKV MN Serotonin transporter (SERT) DM54AKV MT DTT DM54AKV MA Inhibitor DM54AKV RN Des-keto lobeline analogs with increased potency and selectivity at dopamine and serotonin transporters. Bioorg Med Chem Lett. 2006 Oct 1;16(19):5018-21. DM54AKV RU https://pubmed.ncbi.nlm.nih.gov/16905316 DMEAGI6 DI DMEAGI6 DMEAGI6 DN 10-trifluoroacetyl-DDACTHF DMEAGI6 MI TTEXB9Z DMEAGI6 MN Glycinamide ribonucleotide formyltransferase (GART) DMEAGI6 MT DTT DMEAGI6 MA Inhibitor DMEAGI6 RN Discovery of a potent, nonpolyglutamatable inhibitor of glycinamide ribonucleotide transformylase. J Med Chem. 2006 May 18;49(10):2998-3002. DMEAGI6 RU https://pubmed.ncbi.nlm.nih.gov/16686541 DMIRSA5 DI DMIRSA5 DMIRSA5 DN 10Z-Hymenialdisine DMIRSA5 MI TTH6V3D DMIRSA5 MN Cyclin-dependent kinase 1 (CDK1) DMIRSA5 MT DTT DMIRSA5 MA Binder DMIRSA5 RN DrugBank: a knowledgebase for drugs, drug actions and drug targets. Nucleic Acids Res. 2008 Jan;36(Database issue):D901-6. DMIRSA5 RU https://pubmed.ncbi.nlm.nih.gov/18048412 DMIRSA5 DI DMIRSA5 DMIRSA5 DN 10Z-Hymenialdisine DMIRSA5 MI TT7HF4W DMIRSA5 MN Cyclin-dependent kinase 2 (CDK2) DMIRSA5 MT DTT DMIRSA5 MA Inhibitor DMIRSA5 RN Pharmacological inhibitors of cyclin-dependent kinases. Trends Pharmacol Sci. 2002 Sep;23(9):417-25. DMIRSA5 RU https://pubmed.ncbi.nlm.nih.gov/12237154 DMIRSA5 DI DMIRSA5 DMIRSA5 DN 10Z-Hymenialdisine DMIRSA5 MI TTL4Q97 DMIRSA5 MN Cyclin-dependent kinase 5 (CDK5) DMIRSA5 MT DTT DMIRSA5 MA Inhibitor DMIRSA5 RN Pharmacological inhibitors of cyclin-dependent kinases. Trends Pharmacol Sci. 2002 Sep;23(9):417-25. DMIRSA5 RU https://pubmed.ncbi.nlm.nih.gov/12237154 DME0OGM DI DME0OGM DME0OGM DN 11,12-dihydro-dibenzo[a,e]cyclooctene-5,6-dione DME0OGM MI TTMF541 DME0OGM MN Liver carboxylesterase (CES1) DME0OGM MT DTT DME0OGM MA Inhibitor DME0OGM RN Planarity and constraint of the carbonyl groups in 1,2-diones are determinants for selective inhibition of human carboxylesterase 1. J Med Chem. 2007 Nov 15;50(23):5727-34. DME0OGM RU https://pubmed.ncbi.nlm.nih.gov/17941623 DMFVP6K DI DMFVP6K DMFVP6K DN 11A1 DMFVP6K MI TTE4KHA DMFVP6K MN Amyloid beta A4 protein (APP) DMFVP6K MT DTT DMFVP6K RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2402). DMFVP6K RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2402 DM0EPJT DI DM0EPJT DM0EPJT DN 11BETA,13-DIHYDRO-10-EPI-8-DEOXYCUMAM-BRIN B DM0EPJT MI TTSZLWK DM0EPJT MN Aromatase (CYP19A1) DM0EPJT MT DTT DM0EPJT MA Inhibitor DM0EPJT RN Pharmacophore modeling strategies for the development of novel nonsteroidal inhibitors of human aromatase (CYP19). Bioorg Med Chem Lett. 2010 May 15;20(10):3050-64. DM0EPJT RU https://pubmed.ncbi.nlm.nih.gov/20413308 DMH5QEA DI DMH5QEA DMH5QEA DN 11-Butyryloxy-N-n-propylnoraporphine DMH5QEA MI TTJQOD7 DMH5QEA MN 5-HT 2A receptor (HTR2A) DMH5QEA MT DTT DMH5QEA MA Inhibitor DMH5QEA RN N-Propylnoraporphin-11-O-yl carboxylic esters as potent dopamine D(2) and serotonin 5-HT(1A) receptor dual ligands. Bioorg Med Chem. 2008 Sep 15;16(18):8335-8. DMH5QEA RU https://pubmed.ncbi.nlm.nih.gov/18783955 DMH5QEA DI DMH5QEA DMH5QEA DN 11-Butyryloxy-N-n-propylnoraporphine DMH5QEA MI TTZFYLI DMH5QEA MN Dopamine D1 receptor (D1R) DMH5QEA MT DTT DMH5QEA MA Inhibitor DMH5QEA RN N-Propylnoraporphin-11-O-yl carboxylic esters as potent dopamine D(2) and serotonin 5-HT(1A) receptor dual ligands. Bioorg Med Chem. 2008 Sep 15;16(18):8335-8. DMH5QEA RU https://pubmed.ncbi.nlm.nih.gov/18783955 DMYGE3K DI DMYGE3K DMYGE3K DN 11C-PBR-170 DMYGE3K MI TTPTXIN DMYGE3K MN Translocator protein (TSPO) DMYGE3K MT DTT DMYGE3K MA Binder DMYGE3K RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2879). DMYGE3K RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2879 DM1ERJC DI DM1ERJC DM1ERJC DN 11-deoxy-PGE1 DM1ERJC MI TT1ZAVI DM1ERJC MN Prostaglandin E2 receptor EP2 (PTGER2) DM1ERJC MT DTT DM1ERJC MA Agonist DM1ERJC RN Ligand binding specificities of the eight types and subtypes of the mouse prostanoid receptors expressed in Chinese hamster ovary cells. Br J Pharmacol. 1997 Sep;122(2):217-24. DM1ERJC RU https://pubmed.ncbi.nlm.nih.gov/9313928 DM1ERJC DI DM1ERJC DM1ERJC DN 11-deoxy-PGE1 DM1ERJC MI TTPNGDE DM1ERJC MN Prostaglandin E2 receptor EP3 (PTGER3) DM1ERJC MT DTT DM1ERJC MA Agonist DM1ERJC RN Molecular cloning and characterization of the four rat prostaglandin E2 prostanoid receptor subtypes. Eur J Pharmacol. 1997 Dec 11;340(2-3):227-41. DM1ERJC RU https://pubmed.ncbi.nlm.nih.gov/9537820 DM1ERJC DI DM1ERJC DM1ERJC DN 11-deoxy-PGE1 DM1ERJC MI TT79WV3 DM1ERJC MN Prostaglandin E2 receptor EP4 (PTGER4) DM1ERJC MT DTT DM1ERJC MA Agonist DM1ERJC RN Pharmacological characterization of [(3)H]-prostaglandin E(2) binding to the cloned human EP(4) prostanoid receptor. Br J Pharmacol. 2000 Aug;130(8):1919-26. DM1ERJC RU https://pubmed.ncbi.nlm.nih.gov/10952683 DMXLWOK DI DMXLWOK DMXLWOK DN 11-deoxy-PGE2 DMXLWOK MI TT79WV3 DMXLWOK MN Prostaglandin E2 receptor EP4 (PTGER4) DMXLWOK MT DTT DMXLWOK MA Agonist DMXLWOK RN Molecular cloning and characterization of the four rat prostaglandin E2 prostanoid receptor subtypes. Eur J Pharmacol. 1997 Dec 11;340(2-3):227-41. DMXLWOK RU https://pubmed.ncbi.nlm.nih.gov/9537820 DMK41DJ DI DMK41DJ DMK41DJ DN 11H-benzo[a]carbazole DMK41DJ MI TTBGTCW DMK41DJ MN Kinesin spindle messenger RNA (KIF11 mRNA) DMK41DJ MT DTT DMK41DJ MA Inhibitor DMK41DJ RN Kinesin spindle protein (KSP) inhibitors with 2,3-fused indole scaffolds. J Med Chem. 2010 Jul 8;53(13):5054-8. DMK41DJ RU https://pubmed.ncbi.nlm.nih.gov/20521839 DMX4I9D DI DMX4I9D DMX4I9D DN 11-Heptanoyloxy-N-n-propylnoraporphine DMX4I9D MI TTJQOD7 DMX4I9D MN 5-HT 2A receptor (HTR2A) DMX4I9D MT DTT DMX4I9D MA Inhibitor DMX4I9D RN N-Propylnoraporphin-11-O-yl carboxylic esters as potent dopamine D(2) and serotonin 5-HT(1A) receptor dual ligands. Bioorg Med Chem. 2008 Sep 15;16(18):8335-8. DMX4I9D RU https://pubmed.ncbi.nlm.nih.gov/18783955 DMX4I9D DI DMX4I9D DMX4I9D DN 11-Heptanoyloxy-N-n-propylnoraporphine DMX4I9D MI TTZFYLI DMX4I9D MN Dopamine D1 receptor (D1R) DMX4I9D MT DTT DMX4I9D MA Inhibitor DMX4I9D RN N-Propylnoraporphin-11-O-yl carboxylic esters as potent dopamine D(2) and serotonin 5-HT(1A) receptor dual ligands. Bioorg Med Chem. 2008 Sep 15;16(18):8335-8. DMX4I9D RU https://pubmed.ncbi.nlm.nih.gov/18783955 DMRYV9E DI DMRYV9E DMRYV9E DN 11-Hexanoyloxy-N-n-propylnoraporphine DMRYV9E MI TTJQOD7 DMRYV9E MN 5-HT 2A receptor (HTR2A) DMRYV9E MT DTT DMRYV9E MA Inhibitor DMRYV9E RN N-Propylnoraporphin-11-O-yl carboxylic esters as potent dopamine D(2) and serotonin 5-HT(1A) receptor dual ligands. Bioorg Med Chem. 2008 Sep 15;16(18):8335-8. DMRYV9E RU https://pubmed.ncbi.nlm.nih.gov/18783955 DMRYV9E DI DMRYV9E DMRYV9E DN 11-Hexanoyloxy-N-n-propylnoraporphine DMRYV9E MI TTZFYLI DMRYV9E MN Dopamine D1 receptor (D1R) DMRYV9E MT DTT DMRYV9E MA Inhibitor DMRYV9E RN N-Propylnoraporphin-11-O-yl carboxylic esters as potent dopamine D(2) and serotonin 5-HT(1A) receptor dual ligands. Bioorg Med Chem. 2008 Sep 15;16(18):8335-8. DMRYV9E RU https://pubmed.ncbi.nlm.nih.gov/18783955 DMM6CJI DI DMM6CJI DMM6CJI DN 11-keto-beta-boswellicacid DMM6CJI MI TTN7BL9 DMM6CJI MN Corticosteroid 11-beta-dehydrogenase 1 (HSD11B1) DMM6CJI MT DTT DMM6CJI MA Inhibitor DMM6CJI RN 11beta-Hydroxysteroid dehydrogenase 1 inhibiting constituents from Eriobotrya japonica revealed by bioactivity-guided isolation and computational a... Bioorg Med Chem. 2010 Feb 15;18(4):1507-15. DMM6CJI RU https://pubmed.ncbi.nlm.nih.gov/20100662 DMM6CJI DI DMM6CJI DMM6CJI DN 11-keto-beta-boswellicacid DMM6CJI MI TT9H85R DMM6CJI MN Corticosteroid 11-beta-dehydrogenase 2 (HSD11B2) DMM6CJI MT DTT DMM6CJI MA Inhibitor DMM6CJI RN 11beta-Hydroxysteroid dehydrogenase 1 inhibiting constituents from Eriobotrya japonica revealed by bioactivity-guided isolation and computational a... Bioorg Med Chem. 2010 Feb 15;18(4):1507-15. DMM6CJI RU https://pubmed.ncbi.nlm.nih.gov/20100662 DM1WPE3 DI DM1WPE3 DM1WPE3 DN 11-keto-ursolic acid DM1WPE3 MI TTN7BL9 DM1WPE3 MN Corticosteroid 11-beta-dehydrogenase 1 (HSD11B1) DM1WPE3 MT DTT DM1WPE3 MA Inhibitor DM1WPE3 RN 11beta-Hydroxysteroid dehydrogenase 1 inhibiting constituents from Eriobotrya japonica revealed by bioactivity-guided isolation and computational a... Bioorg Med Chem. 2010 Feb 15;18(4):1507-15. DM1WPE3 RU https://pubmed.ncbi.nlm.nih.gov/20100662 DM9IHFY DI DM9IHFY DM9IHFY DN 11-methyl-6,11-dihydro-5H-benzo[a]carbazol-9-ol DM9IHFY MI TTS64P2 DM9IHFY MN Androgen receptor (AR) DM9IHFY MT DTT DM9IHFY MA Inhibitor DM9IHFY RN Discovery of indole-containing tetracycles as a new scaffold for androgen receptor ligands. Bioorg Med Chem Lett. 2006 Jun 15;16(12):3233-7. DM9IHFY RU https://pubmed.ncbi.nlm.nih.gov/16603353 DM62FEH DI DM62FEH DM62FEH DN 11-Propionyloxy-N-n-propylnoraporphine DM62FEH MI TTJQOD7 DM62FEH MN 5-HT 2A receptor (HTR2A) DM62FEH MT DTT DM62FEH MA Inhibitor DM62FEH RN N-Propylnoraporphin-11-O-yl carboxylic esters as potent dopamine D(2) and serotonin 5-HT(1A) receptor dual ligands. Bioorg Med Chem. 2008 Sep 15;16(18):8335-8. DM62FEH RU https://pubmed.ncbi.nlm.nih.gov/18783955 DM62FEH DI DM62FEH DM62FEH DN 11-Propionyloxy-N-n-propylnoraporphine DM62FEH MI TTZFYLI DM62FEH MN Dopamine D1 receptor (D1R) DM62FEH MT DTT DM62FEH MA Inhibitor DM62FEH RN N-Propylnoraporphin-11-O-yl carboxylic esters as potent dopamine D(2) and serotonin 5-HT(1A) receptor dual ligands. Bioorg Med Chem. 2008 Sep 15;16(18):8335-8. DM62FEH RU https://pubmed.ncbi.nlm.nih.gov/18783955 DMM91WE DI DMM91WE DMM91WE DN 11-valeryloxynoraporphine DMM91WE MI TTJQOD7 DMM91WE MN 5-HT 2A receptor (HTR2A) DMM91WE MT DTT DMM91WE MA Inhibitor DMM91WE RN N-Propylnoraporphin-11-O-yl carboxylic esters as potent dopamine D(2) and serotonin 5-HT(1A) receptor dual ligands. Bioorg Med Chem. 2008 Sep 15;16(18):8335-8. DMM91WE RU https://pubmed.ncbi.nlm.nih.gov/18783955 DMM91WE DI DMM91WE DMM91WE DN 11-valeryloxynoraporphine DMM91WE MI TTZFYLI DMM91WE MN Dopamine D1 receptor (D1R) DMM91WE MT DTT DMM91WE MA Inhibitor DMM91WE RN N-Propylnoraporphin-11-O-yl carboxylic esters as potent dopamine D(2) and serotonin 5-HT(1A) receptor dual ligands. Bioorg Med Chem. 2008 Sep 15;16(18):8335-8. DMM91WE RU https://pubmed.ncbi.nlm.nih.gov/18783955 DM84YCI DI DM84YCI DM84YCI DN 12-(3-Adamantan-1-yl-ureido)-dodeca noic acid DM84YCI MI TT7WVHI DM84YCI MN Soluble epoxide hydrolase (EPHX2) DM84YCI MT DTT DM84YCI MA Inhibitor DM84YCI RN Discovery of a highly potent, selective, and bioavailable soluble epoxide hydrolase inhibitor with excellent ex vivo target engagement. J Med Chem. 2009 Aug 27;52(16):5009-12. DM84YCI RU https://pubmed.ncbi.nlm.nih.gov/19645482 DM0F3SR DI DM0F3SR DM0F3SR DN 12-(3-n-Hexylureido)dodec-8(Z)-enoic acid DM0F3SR MI TT7WVHI DM0F3SR MN Soluble epoxide hydrolase (EPHX2) DM0F3SR MT DTT DM0F3SR MA Inhibitor DM0F3SR RN 14,15-Epoxyeicosa-5,8,11-trienoic acid (14,15-EET) surrogates containing epoxide bioisosteres: influence upon vascular relaxation and soluble epoxi... J Med Chem. 2009 Aug 27;52(16):5069-75. DM0F3SR RU https://pubmed.ncbi.nlm.nih.gov/19653681 DMAFNXZ DI DMAFNXZ DMAFNXZ DN 12-(3-n-Pentylureidooxy)dodec-8(Z)-enoic acid DMAFNXZ MI TT7WVHI DMAFNXZ MN Soluble epoxide hydrolase (EPHX2) DMAFNXZ MT DTT DMAFNXZ MA Inhibitor DMAFNXZ RN 14,15-Epoxyeicosa-5,8,11-trienoic acid (14,15-EET) surrogates containing epoxide bioisosteres: influence upon vascular relaxation and soluble epoxi... J Med Chem. 2009 Aug 27;52(16):5069-75. DMAFNXZ RU https://pubmed.ncbi.nlm.nih.gov/19653681 DMVP39I DI DMVP39I DMVP39I DN 12,13-DEHYDRO-8-O-ACETYLMANZAMINE A DMVP39I MI TTRSMW9 DMVP39I MN Glycogen synthase kinase-3 beta (GSK-3B) DMVP39I MT DTT DMVP39I MA Inhibitor DMVP39I RN Glycogen synthase kinase-3 (GSK-3) inhibitory activity and structure-activity relationship (SAR) studies of the manzamine alkaloids. Potential for ... J Nat Prod. 2007 Sep;70(9):1397-405. DMVP39I RU https://pubmed.ncbi.nlm.nih.gov/17708655 DM8XAWU DI DM8XAWU DM8XAWU DN 12,13-DEHYDROMANZAMINE A DM8XAWU MI TTRSMW9 DM8XAWU MN Glycogen synthase kinase-3 beta (GSK-3B) DM8XAWU MT DTT DM8XAWU MA Inhibitor DM8XAWU RN Glycogen synthase kinase-3 (GSK-3) inhibitory activity and structure-activity relationship (SAR) studies of the manzamine alkaloids. Potential for ... J Nat Prod. 2007 Sep;70(9):1397-405. DM8XAWU RU https://pubmed.ncbi.nlm.nih.gov/17708655 DMAUPQR DI DMAUPQR DMAUPQR DN 12,17-dehydroxyriccardin C DMAUPQR MI TTECBXN DMAUPQR MN Oxysterols receptor LXR-alpha (NR1H3) DMAUPQR MT DTT DMAUPQR MA Inhibitor DMAUPQR RN Co-existence of alpha-glucosidase-inhibitory and liver X receptor-regulatory activities and their separation by structural development. Bioorg Med Chem. 2008 Apr 15;16(8):4272-85. DMAUPQR RU https://pubmed.ncbi.nlm.nih.gov/18343126 DMAUPQR DI DMAUPQR DMAUPQR DN 12,17-dehydroxyriccardin C DMAUPQR MI TTXA6PH DMAUPQR MN Oxysterols receptor LXR-beta (NR1H2) DMAUPQR MT DTT DMAUPQR MA Inhibitor DMAUPQR RN Co-existence of alpha-glucosidase-inhibitory and liver X receptor-regulatory activities and their separation by structural development. Bioorg Med Chem. 2008 Apr 15;16(8):4272-85. DMAUPQR RU https://pubmed.ncbi.nlm.nih.gov/18343126 DMW172Q DI DMW172Q DMW172Q DN 123I-DRM-106 DMW172Q MI TTE4KHA DMW172Q MN Amyloid beta A4 protein (APP) DMW172Q MT DTT DMW172Q MA Modulator DMW172Q RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2402). DMW172Q RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2402 DMTOSXF DI DMTOSXF DMTOSXF DN 12-dehydroxyriccardin C DMTOSXF MI TTECBXN DMTOSXF MN Oxysterols receptor LXR-alpha (NR1H3) DMTOSXF MT DTT DMTOSXF MA Inhibitor DMTOSXF RN Co-existence of alpha-glucosidase-inhibitory and liver X receptor-regulatory activities and their separation by structural development. Bioorg Med Chem. 2008 Apr 15;16(8):4272-85. DMTOSXF RU https://pubmed.ncbi.nlm.nih.gov/18343126 DMTOSXF DI DMTOSXF DMTOSXF DN 12-dehydroxyriccardin C DMTOSXF MI TTXA6PH DMTOSXF MN Oxysterols receptor LXR-beta (NR1H2) DMTOSXF MT DTT DMTOSXF MA Inhibitor DMTOSXF RN Co-existence of alpha-glucosidase-inhibitory and liver X receptor-regulatory activities and their separation by structural development. Bioorg Med Chem. 2008 Apr 15;16(8):4272-85. DMTOSXF RU https://pubmed.ncbi.nlm.nih.gov/18343126 DM9JI8C DI DM9JI8C DM9JI8C DN 12-epi LTB4 DM9JI8C MI TTVJX54 DM9JI8C MN Leukotriene B4 receptor 2 (LTB4R2) DM9JI8C MT DTT DM9JI8C MA Agonist DM9JI8C RN Hydroxyeicosanoids bind to and activate the low affinity leukotriene B4 receptor, BLT2. J Biol Chem. 2001 Apr 13;276(15):12454-9. DM9JI8C RU https://pubmed.ncbi.nlm.nih.gov/11278893 DMZ9PW3 DI DMZ9PW3 DMZ9PW3 DN 12-EPI-SALVINORIN A DMZ9PW3 MI TTQW87Y DMZ9PW3 MN Opioid receptor kappa (OPRK1) DMZ9PW3 MT DTT DMZ9PW3 MA Inhibitor DMZ9PW3 RN Modification of the furan ring of salvinorin A: identification of a selective partial agonist at the kappa opioid receptor. Bioorg Med Chem. 2009 Feb 1;17(3):1370-80. DMZ9PW3 RU https://pubmed.ncbi.nlm.nih.gov/19147366 DMA2EIK DI DMA2EIK DMA2EIK DN 12-hydroxyheptadecatrienoic acid DMA2EIK MI TTVJX54 DMA2EIK MN Leukotriene B4 receptor 2 (LTB4R2) DMA2EIK MT DTT DMA2EIK MA Agonist DMA2EIK RN 12(S)-Hydroxyheptadeca-5Z, 8E, 10E-trienoic acid is a natural ligand for leukotriene B4 receptor 2. J Exp Med. 2008 Apr 14;205(4):759-66. DMA2EIK RU https://pubmed.ncbi.nlm.nih.gov/18378794 DMKH0OC DI DMKH0OC DMKH0OC DN 12-O-deacetyl-12-epi-19-deoxy-21-hydroxyscalarin DMKH0OC MI TTS4UGC DMKH0OC MN Farnesoid X-activated receptor (FXR) DMKH0OC MT DTT DMKH0OC MA Inhibitor DMKH0OC RN Scalarane sesterterpenes from a marine sponge of the genus Spongia and their FXR antagonistic activity. J Nat Prod. 2007 Nov;70(11):1691-5. DMKH0OC RU https://pubmed.ncbi.nlm.nih.gov/17988093 DMLR2FB DI DMLR2FB DMLR2FB DN 12-Phenylheme DMLR2FB MI TTI6V2A DMLR2FB MN Heme oxygenase 1 (HMOX1) DMLR2FB MT DTT DMLR2FB MA Inhibitor DMLR2FB RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMLR2FB RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMK0GJ3 DI DMK0GJ3 DMK0GJ3 DN 12R-HETE DMK0GJ3 MI TTVJX54 DMK0GJ3 MN Leukotriene B4 receptor 2 (LTB4R2) DMK0GJ3 MT DTT DMK0GJ3 MA Agonist DMK0GJ3 RN A G-protein-coupled receptor for leukotriene B4 that mediates chemotaxis. Nature. 1997 Jun 5;387(6633):620-4. DMK0GJ3 RU https://pubmed.ncbi.nlm.nih.gov/9177352 DMBEZ09 DI DMBEZ09 DMBEZ09 DN 12S-HETE DMBEZ09 MI TT71ZLK DMBEZ09 MN G-protein coupled receptor 31 (GPR31) DMBEZ09 MT DTT DMBEZ09 MA Agonist DMBEZ09 RN Identification of the orphan G protein-coupled receptor GPR31 as a receptor for 12-(S)-hydroxyeicosatetraenoic acid. J Biol Chem. 2011 Sep 30;286(39):33832-40. DMBEZ09 RU https://pubmed.ncbi.nlm.nih.gov/21712392 DMBEZ09 DI DMBEZ09 DMBEZ09 DN 12S-HETE DMBEZ09 MI TTVJX54 DMBEZ09 MN Leukotriene B4 receptor 2 (LTB4R2) DMBEZ09 MT DTT DMBEZ09 MA Agonist DMBEZ09 RN Hydroxyeicosanoids bind to and activate the low affinity leukotriene B4 receptor, BLT2. J Biol Chem. 2001 Apr 13;276(15):12454-9. DMBEZ09 RU https://pubmed.ncbi.nlm.nih.gov/11278893 DM6ZX1O DI DM6ZX1O DM6ZX1O DN 12S-HPETE DM6ZX1O MI TTMI6F5 DM6ZX1O MN Transient receptor potential cation channel V1 (TRPV1) DM6ZX1O MT DTT DM6ZX1O MA Activator DM6ZX1O RN Direct activation of capsaicin receptors by products of lipoxygenases: endogenous capsaicin-like substances. Proc Natl Acad Sci U S A. 2000 May 23;97(11):6155-60. DM6ZX1O RU https://pubmed.ncbi.nlm.nih.gov/10823958 DMRO1IU DI DMRO1IU DMRO1IU DN 1-3 Sugar Ring of Pentamannosyl 6-Phosphate DMRO1IU MI TT95ICL DMRO1IU MN Mannose-6-phosphate receptor (M6PR) DMRO1IU MT DTT DMRO1IU MA Inhibitor DMRO1IU RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMRO1IU RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMIY9DB DI DMIY9DB DMIY9DB DN 13-(3-n-Pentylthioureido)tridec-8(Z)-enoic Acid DMIY9DB MI TT7WVHI DMIY9DB MN Soluble epoxide hydrolase (EPHX2) DMIY9DB MT DTT DMIY9DB MA Inhibitor DMIY9DB RN 14,15-Epoxyeicosa-5,8,11-trienoic acid (14,15-EET) surrogates containing epoxide bioisosteres: influence upon vascular relaxation and soluble epoxi... J Med Chem. 2009 Aug 27;52(16):5069-75. DMIY9DB RU https://pubmed.ncbi.nlm.nih.gov/19653681 DM0NRJG DI DM0NRJG DM0NRJG DN 13-(3-n-Pentylureido)tridec-5(Z)-enoic acid DM0NRJG MI TT7WVHI DM0NRJG MN Soluble epoxide hydrolase (EPHX2) DM0NRJG MT DTT DM0NRJG MA Inhibitor DM0NRJG RN 14,15-Epoxyeicosa-5,8,11-trienoic acid (14,15-EET) surrogates containing epoxide bioisosteres: influence upon vascular relaxation and soluble epoxi... J Med Chem. 2009 Aug 27;52(16):5069-75. DM0NRJG RU https://pubmed.ncbi.nlm.nih.gov/19653681 DM17DY6 DI DM17DY6 DM17DY6 DN 13-(3-n-Pentylureido)tridec-8(E)-enoic acid DM17DY6 MI TT7WVHI DM17DY6 MN Soluble epoxide hydrolase (EPHX2) DM17DY6 MT DTT DM17DY6 MA Inhibitor DM17DY6 RN 14,15-Epoxyeicosa-5,8,11-trienoic acid (14,15-EET) surrogates containing epoxide bioisosteres: influence upon vascular relaxation and soluble epoxi... J Med Chem. 2009 Aug 27;52(16):5069-75. DM17DY6 RU https://pubmed.ncbi.nlm.nih.gov/19653681 DM9VDOG DI DM9VDOG DM9VDOG DN 13-(3-n-Pentylureido)tridec-8-ynoic acid DM9VDOG MI TT7WVHI DM9VDOG MN Soluble epoxide hydrolase (EPHX2) DM9VDOG MT DTT DM9VDOG MA Inhibitor DM9VDOG RN 14,15-Epoxyeicosa-5,8,11-trienoic acid (14,15-EET) surrogates containing epoxide bioisosteres: influence upon vascular relaxation and soluble epoxi... J Med Chem. 2009 Aug 27;52(16):5069-75. DM9VDOG RU https://pubmed.ncbi.nlm.nih.gov/19653681 DM3I6PS DI DM3I6PS DM3I6PS DN 13-(3-Pentyluredo)tridec-8(Z)-enoic acid DM3I6PS MI TT7WVHI DM3I6PS MN Soluble epoxide hydrolase (EPHX2) DM3I6PS MT DTT DM3I6PS MA Inhibitor DM3I6PS RN 14,15-Epoxyeicosa-5,8,11-trienoic acid (14,15-EET) surrogates containing epoxide bioisosteres: influence upon vascular relaxation and soluble epoxi... J Med Chem. 2009 Aug 27;52(16):5069-75. DM3I6PS RU https://pubmed.ncbi.nlm.nih.gov/19653681 DM8HRTC DI DM8HRTC DM8HRTC DN 13-(5-n-Pentylfuran-2-yl)tridec-8(Z)-enoic acid DM8HRTC MI TT7WVHI DM8HRTC MN Soluble epoxide hydrolase (EPHX2) DM8HRTC MT DTT DM8HRTC MA Inhibitor DM8HRTC RN 14,15-Epoxyeicosa-5,8,11-trienoic acid (14,15-EET) surrogates containing epoxide bioisosteres: influence upon vascular relaxation and soluble epoxi... J Med Chem. 2009 Aug 27;52(16):5069-75. DM8HRTC RU https://pubmed.ncbi.nlm.nih.gov/19653681 DMXK6D2 DI DMXK6D2 DMXK6D2 DN 13-(N-Isopropylheptanamido)tridec-8(Z)-enoic acid DMXK6D2 MI TT7WVHI DMXK6D2 MN Soluble epoxide hydrolase (EPHX2) DMXK6D2 MT DTT DMXK6D2 MA Inhibitor DMXK6D2 RN 14,15-Epoxyeicosa-5,8,11-trienoic acid (14,15-EET) surrogates containing epoxide bioisosteres: influence upon vascular relaxation and soluble epoxi... J Med Chem. 2009 Aug 27;52(16):5069-75. DMXK6D2 RU https://pubmed.ncbi.nlm.nih.gov/19653681 DM689TH DI DM689TH DM689TH DN 13-(N-Methyl-n-heptnamido)tridec-8(Z)-enoic acid DM689TH MI TT7WVHI DM689TH MN Soluble epoxide hydrolase (EPHX2) DM689TH MT DTT DM689TH MA Inhibitor DM689TH RN 14,15-Epoxyeicosa-5,8,11-trienoic acid (14,15-EET) surrogates containing epoxide bioisosteres: influence upon vascular relaxation and soluble epoxi... J Med Chem. 2009 Aug 27;52(16):5069-75. DM689TH RU https://pubmed.ncbi.nlm.nih.gov/19653681 DMSF3C8 DI DMSF3C8 DMSF3C8 DN 13-(n-Pentylcarbamoyloxy)tridec-8(Z)-enoic acid DMSF3C8 MI TT7WVHI DMSF3C8 MN Soluble epoxide hydrolase (EPHX2) DMSF3C8 MT DTT DMSF3C8 MA Inhibitor DMSF3C8 RN 14,15-Epoxyeicosa-5,8,11-trienoic acid (14,15-EET) surrogates containing epoxide bioisosteres: influence upon vascular relaxation and soluble epoxi... J Med Chem. 2009 Aug 27;52(16):5069-75. DMSF3C8 RU https://pubmed.ncbi.nlm.nih.gov/19653681 DMZVWCG DI DMZVWCG DMZVWCG DN 13,14-dihydro-15-keto-PGD2 DMZVWCG MI TTQDMX5 DMZVWCG MN Prostaglandin D2 receptor 2 (PTGDR2) DMZVWCG MT DTT DMZVWCG MA Agonist DMZVWCG RN CRTH2-specific binding characteristics of [3H]ramatroban and its effects on PGD2-, 15-deoxy-Delta12, 14-PGJ2- and indomethacin-induced agonist resp... Eur J Pharmacol. 2005 Nov 7;524(1-3):30-7. DMZVWCG RU https://pubmed.ncbi.nlm.nih.gov/16256979 DMNT1XI DI DMNT1XI DMNT1XI DN 13,14-dihydro-15-keto-PGF2alpha DMNT1XI MI TTQDMX5 DMNT1XI MN Prostaglandin D2 receptor 2 (PTGDR2) DMNT1XI MT DTT DMNT1XI MA Agonist DMNT1XI RN Molecular pharmacology of the human prostaglandin D2 receptor, CRTH2. Br J Pharmacol. 2002 Dec;137(8):1163-72. DMNT1XI RU https://pubmed.ncbi.nlm.nih.gov/12466225 DMNRMTX DI DMNRMTX DMNRMTX DN 13,14-dihydro-16-m-chlorophenoxy-w-tetranor-PGF1alpha DMNRMTX MI TTT2ZAR DMNRMTX MN Prostaglandin F2-alpha receptor (PTGFR) DMNRMTX MT DTT DMNRMTX MA Agonist DMNRMTX RN Design and synthesis of 13,14-dihydro prostaglandin F(1alpha) analogues as potent and selective ligands for the human FP receptor. J Med Chem. 2000 Mar 9;43(5):945-52. DMNRMTX RU https://pubmed.ncbi.nlm.nih.gov/10715159 DMTEACQ DI DMTEACQ DMTEACQ DN 13,14-dihydro-PGE1 DMTEACQ MI TT79WV3 DMTEACQ MN Prostaglandin E2 receptor EP4 (PTGER4) DMTEACQ MT DTT DMTEACQ MA Agonist DMTEACQ RN Pharmacological characterization of [(3)H]-prostaglandin E(2) binding to the cloned human EP(4) prostanoid receptor. Br J Pharmacol. 2000 Aug;130(8):1919-26. DMTEACQ RU https://pubmed.ncbi.nlm.nih.gov/10952683 DMMTPK3 DI DMMTPK3 DMMTPK3 DN 135PAM1 DMMTPK3 MI TT64ZVP DMMTPK3 MN Relaxin-3 receptor 1 (RXFP3) DMMTPK3 MT DTT DMMTPK3 MA Modulator (allosteric modulator) DMMTPK3 RN In vitro pharmacological characterization of RXFP3 allosterism: an example of probe dependency. PLoS One. 2012;7(2):e30792. DMMTPK3 RU https://pubmed.ncbi.nlm.nih.gov/22347403 DMJ2T7P DI DMJ2T7P DMJ2T7P DN 13-Acetylphorbol DMJ2T7P MI TT9WJ8U DMJ2T7P MN Protein kinase C delta (PRKCD) DMJ2T7P MT DTT DMJ2T7P MA Inhibitor DMJ2T7P RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DMJ2T7P RU https://pubmed.ncbi.nlm.nih.gov/10592235 DMRVQCB DI DMRVQCB DMRVQCB DN 13-n-Heptanamidotridec-5-ynoic acid DMRVQCB MI TT7WVHI DMRVQCB MN Soluble epoxide hydrolase (EPHX2) DMRVQCB MT DTT DMRVQCB MA Inhibitor DMRVQCB RN 14,15-Epoxyeicosa-5,8,11-trienoic acid (14,15-EET) surrogates containing epoxide bioisosteres: influence upon vascular relaxation and soluble epoxi... J Med Chem. 2009 Aug 27;52(16):5069-75. DMRVQCB RU https://pubmed.ncbi.nlm.nih.gov/19653681 DM0LGWJ DI DM0LGWJ DM0LGWJ DN 13-n-Heptanamidotridec-8(Z)-enoic acid DM0LGWJ MI TT7WVHI DM0LGWJ MN Soluble epoxide hydrolase (EPHX2) DM0LGWJ MT DTT DM0LGWJ MA Inhibitor DM0LGWJ RN 14,15-Epoxyeicosa-5,8,11-trienoic acid (14,15-EET) surrogates containing epoxide bioisosteres: influence upon vascular relaxation and soluble epoxi... J Med Chem. 2009 Aug 27;52(16):5069-75. DM0LGWJ RU https://pubmed.ncbi.nlm.nih.gov/19653681 DM5NFB6 DI DM5NFB6 DM5NFB6 DN 14-(n-Hexylamino)-14-oxotetradec-8(Z)-enoic acid DM5NFB6 MI TT7WVHI DM5NFB6 MN Soluble epoxide hydrolase (EPHX2) DM5NFB6 MT DTT DM5NFB6 MA Inhibitor DM5NFB6 RN 14,15-Epoxyeicosa-5,8,11-trienoic acid (14,15-EET) surrogates containing epoxide bioisosteres: influence upon vascular relaxation and soluble epoxi... J Med Chem. 2009 Aug 27;52(16):5069-75. DM5NFB6 RU https://pubmed.ncbi.nlm.nih.gov/19653681 DMLZT64 DI DMLZT64 DMLZT64 DN 1400W DMLZT64 MI TTZUFI5 DMLZT64 MN Nitric-oxide synthase brain (NOS1) DMLZT64 MT DTT DMLZT64 MA Inhibitor DMLZT64 RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DMLZT64 RU https://pubmed.ncbi.nlm.nih.gov/10592235 DMLZT64 DI DMLZT64 DMLZT64 DN 1400W DMLZT64 MI TTCM4B3 DMLZT64 MN Nitric-oxide synthase endothelial (NOS3) DMLZT64 MT DTT DMLZT64 MA Inhibitor DMLZT64 RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DMLZT64 RU https://pubmed.ncbi.nlm.nih.gov/10592235 DMLZT64 DI DMLZT64 DMLZT64 DN 1400W DMLZT64 MI TTF10I9 DMLZT64 MN Nitric-oxide synthase inducible (NOS2) DMLZT64 MT DTT DMLZT64 MA Inhibitor DMLZT64 RN 1400W is a slow, tight binding, and highly selective inhibitor of inducible nitric-oxide synthase in vitro and in vivo. J Biol Chem. 1997 Feb 21;272(8):4959-63. DMLZT64 RU https://pubmed.ncbi.nlm.nih.gov/9030556 DMI7LXH DI DMI7LXH DMI7LXH DN 14-O-phenylpropylnaltrexone DMI7LXH MI TT27RFC DMI7LXH MN Opioid receptor delta (OPRD1) DMI7LXH MT DTT DMI7LXH MA Inhibitor DMI7LXH RN 14 beta-O-cinnamoylnaltrexone and related dihydrocodeinones are mu opioid receptor partial agonists with predominant antagonist activity. J Med Chem. 2009 Mar 26;52(6):1553-7. DMI7LXH RU https://pubmed.ncbi.nlm.nih.gov/19253983 DMI7LXH DI DMI7LXH DMI7LXH DN 14-O-phenylpropylnaltrexone DMI7LXH MI TTQW87Y DMI7LXH MN Opioid receptor kappa (OPRK1) DMI7LXH MT DTT DMI7LXH MA Inhibitor DMI7LXH RN 14 beta-O-cinnamoylnaltrexone and related dihydrocodeinones are mu opioid receptor partial agonists with predominant antagonist activity. J Med Chem. 2009 Mar 26;52(6):1553-7. DMI7LXH RU https://pubmed.ncbi.nlm.nih.gov/19253983 DMI7LXH DI DMI7LXH DMI7LXH DN 14-O-phenylpropylnaltrexone DMI7LXH MI TTKWM86 DMI7LXH MN Opioid receptor mu (MOP) DMI7LXH MT DTT DMI7LXH MA Inhibitor DMI7LXH RN 14 beta-O-cinnamoylnaltrexone and related dihydrocodeinones are mu opioid receptor partial agonists with predominant antagonist activity. J Med Chem. 2009 Mar 26;52(6):1553-7. DMI7LXH RU https://pubmed.ncbi.nlm.nih.gov/19253983 DMY9ZT8 DI DMY9ZT8 DMY9ZT8 DN 15(R)-15-methyl-PGD2 DMY9ZT8 MI TTQDMX5 DMY9ZT8 MN Prostaglandin D2 receptor 2 (PTGDR2) DMY9ZT8 MT DTT DMY9ZT8 MA Agonist DMY9ZT8 RN CRTH2-specific binding characteristics of [3H]ramatroban and its effects on PGD2-, 15-deoxy-Delta12, 14-PGJ2- and indomethacin-induced agonist resp... Eur J Pharmacol. 2005 Nov 7;524(1-3):30-7. DMY9ZT8 RU https://pubmed.ncbi.nlm.nih.gov/16256979 DMG273T DI DMG273T DMG273T DN 15(S)-15-methyl-PGD2 DMG273T MI TTQDMX5 DMG273T MN Prostaglandin D2 receptor 2 (PTGDR2) DMG273T MT DTT DMG273T MA Agonist DMG273T RN Molecular pharmacology of the human prostaglandin D2 receptor, CRTH2. Br J Pharmacol. 2002 Dec;137(8):1163-72. DMG273T RU https://pubmed.ncbi.nlm.nih.gov/12466225 DMLSZW2 DI DMLSZW2 DMLSZW2 DN 15-ACETOXY-EREMANTHOLIDE B DMLSZW2 MI TTSXVID DMLSZW2 MN Nuclear factor NF-kappa-B (NFKB) DMLSZW2 MT DTT DMLSZW2 MA Inhibitor DMLSZW2 RN Quantitative structure-activity relationship of sesquiterpene lactones as inhibitors of the transcription factor NF-kappaB. J Med Chem. 2004 Nov 18;47(24):6042-54. DMLSZW2 RU https://pubmed.ncbi.nlm.nih.gov/15537359 DMJC0NQ DI DMJC0NQ DMJC0NQ DN 15-DEOXYBUDLEIN A DMJC0NQ MI TTSXVID DMJC0NQ MN Nuclear factor NF-kappa-B (NFKB) DMJC0NQ MT DTT DMJC0NQ MA Inhibitor DMJC0NQ RN Quantitative structure-activity relationship of sesquiterpene lactones as inhibitors of the transcription factor NF-kappaB. J Med Chem. 2004 Nov 18;47(24):6042-54. DMJC0NQ RU https://pubmed.ncbi.nlm.nih.gov/15537359 DM8VUX3 DI DM8VUX3 DM8VUX3 DN 15-deoxy-Delta(12, 14)-prostaglandin J(2) DM8VUX3 MI TTZMAO3 DM8VUX3 MN Peroxisome proliferator-activated receptor gamma (PPAR-gamma) DM8VUX3 MT DTT DM8VUX3 MA Agonist DM8VUX3 RN Expression of peroxisome proliferator-activated receptors (PPARs) in human urinary bladder carcinoma and growth inhibition by its agonists. Int J Cancer. 2003 May 1;104(5):597-602. DM8VUX3 RU https://pubmed.ncbi.nlm.nih.gov/12594814 DMJ27QT DI DMJ27QT DMJ27QT DN 15-deoxy-Delta12,14-PGD2 DMJ27QT MI TTQDMX5 DMJ27QT MN Prostaglandin D2 receptor 2 (PTGDR2) DMJ27QT MT DTT DMJ27QT MA Agonist DMJ27QT RN Expression and molecular pharmacology of the mouse CRTH2 receptor. J Pharmacol Exp Ther. 2003 Aug;306(2):463-70. DMJ27QT RU https://pubmed.ncbi.nlm.nih.gov/12721327 DMNDECA DI DMNDECA DMNDECA DN 15-deoxy-Delta12,14-PGJ2 DMNDECA MI TTNVEIR DMNDECA MN Prostaglandin D2 receptor (PTGDR) DMNDECA MT DTT DMNDECA MA Agonist DMNDECA RN Characterization of the recombinant human prostanoid DP receptor and identification of L-644,698, a novel selective DP agonist. Br J Pharmacol. 1998 Apr;123(7):1317-24. DMNDECA RU https://pubmed.ncbi.nlm.nih.gov/9579725 DMNDECA DI DMNDECA DMNDECA DN 15-deoxy-Delta12,14-PGJ2 DMNDECA MI TTQDMX5 DMNDECA MN Prostaglandin D2 receptor 2 (PTGDR2) DMNDECA MT DTT DMNDECA MA Agonist DMNDECA RN Expression and molecular pharmacology of the mouse CRTH2 receptor. J Pharmacol Exp Ther. 2003 Aug;306(2):463-70. DMNDECA RU https://pubmed.ncbi.nlm.nih.gov/12721327 DMR9SFM DI DMR9SFM DMR9SFM DN 15-deoxygoiazensolide DMR9SFM MI TTSXVID DMR9SFM MN Nuclear factor NF-kappa-B (NFKB) DMR9SFM MT DTT DMR9SFM MA Inhibitor DMR9SFM RN Development of a structural model for NF-kappaB inhibition of sesquiterpene lactones using self-organizing neural networks. J Med Chem. 2006 Apr 6;49(7):2241-52. DMR9SFM RU https://pubmed.ncbi.nlm.nih.gov/16570920 DMEML8B DI DMEML8B DMEML8B DN 15-hydroxyeicosatetraenoic acid DMEML8B MI TT2J34L DMEML8B MN Arachidonate 5-lipoxygenase (5-LOX) DMEML8B MT DTT DMEML8B MA Inhibitor DMEML8B RN Preview of potential therapeutic applications of leukotriene B4 inhibitors in dermatology. Skin Pharmacol Appl Skin Physiol. 2000 Sep-Oct;13(5):235-45. DMEML8B RU https://pubmed.ncbi.nlm.nih.gov/10940813 DMQCRUG DI DMQCRUG DMQCRUG DN 15-isobutyrylmiguanin DMQCRUG MI TTSXVID DMQCRUG MN Nuclear factor NF-kappa-B (NFKB) DMQCRUG MT DTT DMQCRUG MA Inhibitor DMQCRUG RN Development of a structural model for NF-kappaB inhibition of sesquiterpene lactones using self-organizing neural networks. J Med Chem. 2006 Apr 6;49(7):2241-52. DMQCRUG RU https://pubmed.ncbi.nlm.nih.gov/16570920 DMDKFGX DI DMDKFGX DMDKFGX DN 15-nor-18-Methoxycornaridine DMDKFGX MI TTTVAFQ DMDKFGX MN Neuronal acetylcholine receptor beta-4 (CHRNB4) DMDKFGX MT DTT DMDKFGX MA Inhibitor DMDKFGX RN Synthesis and biological evaluation of 18-methoxycoronaridine congeners. Potential antiaddiction agents. J Med Chem. 2003 Jun 19;46(13):2716-30. DMDKFGX RU https://pubmed.ncbi.nlm.nih.gov/12801235 DM41LV6 DI DM41LV6 DM41LV6 DN 15S-HPETE DM41LV6 MI TTMI6F5 DM41LV6 MN Transient receptor potential cation channel V1 (TRPV1) DM41LV6 MT DTT DM41LV6 MA Activator DM41LV6 RN Direct activation of capsaicin receptors by products of lipoxygenases: endogenous capsaicin-like substances. Proc Natl Acad Sci U S A. 2000 May 23;97(11):6155-60. DM41LV6 RU https://pubmed.ncbi.nlm.nih.gov/10823958 DMK4N2F DI DMK4N2F DMK4N2F DN 16-(2',2'-Dimethyl)-propylidene-estradiol DMK4N2F MI TTIWB6L DMK4N2F MN Estradiol 17 beta-dehydrogenase 1 (17-beta-HSD1) DMK4N2F MT DTT DMK4N2F MA Inhibitor DMK4N2F RN Modification of estrone at the 6, 16, and 17 positions: novel potent inhibitors of 17beta-hydroxysteroid dehydrogenase type 1. J Med Chem. 2006 Feb 23;49(4):1325-45. DMK4N2F RU https://pubmed.ncbi.nlm.nih.gov/16480268 DMQYJB1 DI DMQYJB1 DMQYJB1 DN 16-(2',2'-Dimethyl)-propylidene-estrone DMQYJB1 MI TTIWB6L DMQYJB1 MN Estradiol 17 beta-dehydrogenase 1 (17-beta-HSD1) DMQYJB1 MT DTT DMQYJB1 MA Inhibitor DMQYJB1 RN Modification of estrone at the 6, 16, and 17 positions: novel potent inhibitors of 17beta-hydroxysteroid dehydrogenase type 1. J Med Chem. 2006 Feb 23;49(4):1325-45. DMQYJB1 RU https://pubmed.ncbi.nlm.nih.gov/16480268 DMCHMNF DI DMCHMNF DMCHMNF DN 16-(3-Ethylureido)hexadec-11(Z)-enoic acid DMCHMNF MI TT7WVHI DMCHMNF MN Soluble epoxide hydrolase (EPHX2) DMCHMNF MT DTT DMCHMNF MA Inhibitor DMCHMNF RN 14,15-Epoxyeicosa-5,8,11-trienoic acid (14,15-EET) surrogates containing epoxide bioisosteres: influence upon vascular relaxation and soluble epoxi... J Med Chem. 2009 Aug 27;52(16):5069-75. DMCHMNF RU https://pubmed.ncbi.nlm.nih.gov/19653681 DMTAXZI DI DMTAXZI DMTAXZI DN 16-(4-cyano-benzylidene)-estradiol DMTAXZI MI TTIWB6L DMTAXZI MN Estradiol 17 beta-dehydrogenase 1 (17-beta-HSD1) DMTAXZI MT DTT DMTAXZI MA Inhibitor DMTAXZI RN Modification of estrone at the 6, 16, and 17 positions: novel potent inhibitors of 17beta-hydroxysteroid dehydrogenase type 1. J Med Chem. 2006 Feb 23;49(4):1325-45. DMTAXZI RU https://pubmed.ncbi.nlm.nih.gov/16480268 DMEH8I0 DI DMEH8I0 DMEH8I0 DN 16-(4-dimethylamino-benzylidene)-estradiol DMEH8I0 MI TTIWB6L DMEH8I0 MN Estradiol 17 beta-dehydrogenase 1 (17-beta-HSD1) DMEH8I0 MT DTT DMEH8I0 MA Inhibitor DMEH8I0 RN Modification of estrone at the 6, 16, and 17 positions: novel potent inhibitors of 17beta-hydroxysteroid dehydrogenase type 1. J Med Chem. 2006 Feb 23;49(4):1325-45. DMEH8I0 RU https://pubmed.ncbi.nlm.nih.gov/16480268 DMX8YCK DI DMX8YCK DMX8YCK DN 16-(4-dimethylamino-benzylidene)-estrone DMX8YCK MI TTIWB6L DMX8YCK MN Estradiol 17 beta-dehydrogenase 1 (17-beta-HSD1) DMX8YCK MT DTT DMX8YCK MA Inhibitor DMX8YCK RN Modification of estrone at the 6, 16, and 17 positions: novel potent inhibitors of 17beta-hydroxysteroid dehydrogenase type 1. J Med Chem. 2006 Feb 23;49(4):1325-45. DMX8YCK RU https://pubmed.ncbi.nlm.nih.gov/16480268 DMIC0OU DI DMIC0OU DMIC0OU DN 16-(pyridin-2-yl)methylene-estradiol DMIC0OU MI TTIWB6L DMIC0OU MN Estradiol 17 beta-dehydrogenase 1 (17-beta-HSD1) DMIC0OU MT DTT DMIC0OU MA Inhibitor DMIC0OU RN Modification of estrone at the 6, 16, and 17 positions: novel potent inhibitors of 17beta-hydroxysteroid dehydrogenase type 1. J Med Chem. 2006 Feb 23;49(4):1325-45. DMIC0OU RU https://pubmed.ncbi.nlm.nih.gov/16480268 DMSXFG0 DI DMSXFG0 DMSXFG0 DN 16-(pyridin-2-yl)methyl-estradiol DMSXFG0 MI TTIWB6L DMSXFG0 MN Estradiol 17 beta-dehydrogenase 1 (17-beta-HSD1) DMSXFG0 MT DTT DMSXFG0 MA Inhibitor DMSXFG0 RN Modification of estrone at the 6, 16, and 17 positions: novel potent inhibitors of 17beta-hydroxysteroid dehydrogenase type 1. J Med Chem. 2006 Feb 23;49(4):1325-45. DMSXFG0 RU https://pubmed.ncbi.nlm.nih.gov/16480268 DMIMZ21 DI DMIMZ21 DMIMZ21 DN 16-(pyridin-3-yl)methylene-estradiol DMIMZ21 MI TTIWB6L DMIMZ21 MN Estradiol 17 beta-dehydrogenase 1 (17-beta-HSD1) DMIMZ21 MT DTT DMIMZ21 MA Inhibitor DMIMZ21 RN Modification of estrone at the 6, 16, and 17 positions: novel potent inhibitors of 17beta-hydroxysteroid dehydrogenase type 1. J Med Chem. 2006 Feb 23;49(4):1325-45. DMIMZ21 RU https://pubmed.ncbi.nlm.nih.gov/16480268 DMTD5AO DI DMTD5AO DMTD5AO DN 16-(pyridin-3-yl)methyl-estradiol DMTD5AO MI TTIWB6L DMTD5AO MN Estradiol 17 beta-dehydrogenase 1 (17-beta-HSD1) DMTD5AO MT DTT DMTD5AO MA Inhibitor DMTD5AO RN Modification of estrone at the 6, 16, and 17 positions: novel potent inhibitors of 17beta-hydroxysteroid dehydrogenase type 1. J Med Chem. 2006 Feb 23;49(4):1325-45. DMTD5AO RU https://pubmed.ncbi.nlm.nih.gov/16480268 DMOTNPC DI DMOTNPC DMOTNPC DN 16-(pyridin-4-yl)methylene-estradiol DMOTNPC MI TTIWB6L DMOTNPC MN Estradiol 17 beta-dehydrogenase 1 (17-beta-HSD1) DMOTNPC MT DTT DMOTNPC MA Inhibitor DMOTNPC RN Modification of estrone at the 6, 16, and 17 positions: novel potent inhibitors of 17beta-hydroxysteroid dehydrogenase type 1. J Med Chem. 2006 Feb 23;49(4):1325-45. DMOTNPC RU https://pubmed.ncbi.nlm.nih.gov/16480268 DM7NSRI DI DM7NSRI DM7NSRI DN 16-(pyridin-4-yl)methyl-estradiol DM7NSRI MI TTIWB6L DM7NSRI MN Estradiol 17 beta-dehydrogenase 1 (17-beta-HSD1) DM7NSRI MT DTT DM7NSRI MA Inhibitor DM7NSRI RN Modification of estrone at the 6, 16, and 17 positions: novel potent inhibitors of 17beta-hydroxysteroid dehydrogenase type 1. J Med Chem. 2006 Feb 23;49(4):1325-45. DM7NSRI RU https://pubmed.ncbi.nlm.nih.gov/16480268 DME3XS4 DI DME3XS4 DME3XS4 DN 16-(thiophen-2-yl)methylene-estrone DME3XS4 MI TTIWB6L DME3XS4 MN Estradiol 17 beta-dehydrogenase 1 (17-beta-HSD1) DME3XS4 MT DTT DME3XS4 MA Inhibitor DME3XS4 RN Modification of estrone at the 6, 16, and 17 positions: novel potent inhibitors of 17beta-hydroxysteroid dehydrogenase type 1. J Med Chem. 2006 Feb 23;49(4):1325-45. DME3XS4 RU https://pubmed.ncbi.nlm.nih.gov/16480268 DMI49D0 DI DMI49D0 DMI49D0 DN 16-alphaH,17-isovaleryloxy-ent-kauran-19-oic acid DMI49D0 MI TTELIN2 DMI49D0 MN PTPN1 messenger RNA (PTPN1 mRNA) DMI49D0 MT DTT DMI49D0 MA Inhibitor DMI49D0 RN Inhibition of protein tyrosine phosphatase 1B by diterpenoids isolated from Acanthopanax koreanum. Bioorg Med Chem Lett. 2006 Jun 1;16(11):3061-4. DMI49D0 RU https://pubmed.ncbi.nlm.nih.gov/16545563 DMCMP9B DI DMCMP9B DMCMP9B DN 16beta-cyano-estradiol DMCMP9B MI TTIWB6L DMCMP9B MN Estradiol 17 beta-dehydrogenase 1 (17-beta-HSD1) DMCMP9B MT DTT DMCMP9B MA Inhibitor DMCMP9B RN Modification of estrone at the 6, 16, and 17 positions: novel potent inhibitors of 17beta-hydroxysteroid dehydrogenase type 1. J Med Chem. 2006 Feb 23;49(4):1325-45. DMCMP9B RU https://pubmed.ncbi.nlm.nih.gov/16480268 DMWJNV5 DI DMWJNV5 DMWJNV5 DN 16-beta-ethoxymethyl-estrone DMWJNV5 MI TTIWB6L DMWJNV5 MN Estradiol 17 beta-dehydrogenase 1 (17-beta-HSD1) DMWJNV5 MT DTT DMWJNV5 MA Inhibitor DMWJNV5 RN Modification of estrone at the 6, 16, and 17 positions: novel potent inhibitors of 17beta-hydroxysteroid dehydrogenase type 1. J Med Chem. 2006 Feb 23;49(4):1325-45. DMWJNV5 RU https://pubmed.ncbi.nlm.nih.gov/16480268 DMUW07J DI DMUW07J DMUW07J DN 16-beta-hydroxymethyl-estradiol DMUW07J MI TTIWB6L DMUW07J MN Estradiol 17 beta-dehydrogenase 1 (17-beta-HSD1) DMUW07J MT DTT DMUW07J MA Inhibitor DMUW07J RN Modification of estrone at the 6, 16, and 17 positions: novel potent inhibitors of 17beta-hydroxysteroid dehydrogenase type 1. J Med Chem. 2006 Feb 23;49(4):1325-45. DMUW07J RU https://pubmed.ncbi.nlm.nih.gov/16480268 DMTZG68 DI DMTZG68 DMTZG68 DN 16-isobutylidene-estradiol DMTZG68 MI TTIWB6L DMTZG68 MN Estradiol 17 beta-dehydrogenase 1 (17-beta-HSD1) DMTZG68 MT DTT DMTZG68 MA Inhibitor DMTZG68 RN Modification of estrone at the 6, 16, and 17 positions: novel potent inhibitors of 17beta-hydroxysteroid dehydrogenase type 1. J Med Chem. 2006 Feb 23;49(4):1325-45. DMTZG68 RU https://pubmed.ncbi.nlm.nih.gov/16480268 DMS7PL3 DI DMS7PL3 DMS7PL3 DN 16-isobutylidene-estrone DMS7PL3 MI TTIWB6L DMS7PL3 MN Estradiol 17 beta-dehydrogenase 1 (17-beta-HSD1) DMS7PL3 MT DTT DMS7PL3 MA Inhibitor DMS7PL3 RN Modification of estrone at the 6, 16, and 17 positions: novel potent inhibitors of 17beta-hydroxysteroid dehydrogenase type 1. J Med Chem. 2006 Feb 23;49(4):1325-45. DMS7PL3 RU https://pubmed.ncbi.nlm.nih.gov/16480268 DMDR1M6 DI DMDR1M6 DMDR1M6 DN 17 beta-N,N-diethylcarbamoyl-4-aza-5 alpha-androstan-3-one (4MA) DMDR1M6 MI TTZT9R2 DMDR1M6 MN Hydroxysteroid dehydrogenase 3-beta (HSD3B) DMDR1M6 MT DTT DMDR1M6 MA Inhibitor DMDR1M6 RN Inhibition of 3 beta-hydroxysteroid-dehydrogenase: an approach for prostate cancer treatment Anticancer Res. 1995 Jul-Aug;15(4):1349-54. DMDR1M6 RU https://pubmed.ncbi.nlm.nih.gov/7654020 DMUQWPZ DI DMUQWPZ DMUQWPZ DN 17-(Cyclobutylmethyl)-N-phenylmorphinan-3-amine DMUQWPZ MI TT27RFC DMUQWPZ MN Opioid receptor delta (OPRD1) DMUQWPZ MT DTT DMUQWPZ MA Inhibitor DMUQWPZ RN Synthesis and opioid receptor binding affinities of 2-substituted and 3-aminomorphinans: ligands for mu, kappa, and delta opioid receptors. J Med Chem. 2010 Jan 14;53(1):402-18. DMUQWPZ RU https://pubmed.ncbi.nlm.nih.gov/19928862 DMUQWPZ DI DMUQWPZ DMUQWPZ DN 17-(Cyclobutylmethyl)-N-phenylmorphinan-3-amine DMUQWPZ MI TTQW87Y DMUQWPZ MN Opioid receptor kappa (OPRK1) DMUQWPZ MT DTT DMUQWPZ MA Inhibitor DMUQWPZ RN Synthesis and opioid receptor binding affinities of 2-substituted and 3-aminomorphinans: ligands for mu, kappa, and delta opioid receptors. J Med Chem. 2010 Jan 14;53(1):402-18. DMUQWPZ RU https://pubmed.ncbi.nlm.nih.gov/19928862 DMUQWPZ DI DMUQWPZ DMUQWPZ DN 17-(Cyclobutylmethyl)-N-phenylmorphinan-3-amine DMUQWPZ MI TTKWM86 DMUQWPZ MN Opioid receptor mu (MOP) DMUQWPZ MT DTT DMUQWPZ MA Inhibitor DMUQWPZ RN Synthesis and opioid receptor binding affinities of 2-substituted and 3-aminomorphinans: ligands for mu, kappa, and delta opioid receptors. J Med Chem. 2010 Jan 14;53(1):402-18. DMUQWPZ RU https://pubmed.ncbi.nlm.nih.gov/19928862 DM174HN DI DM174HN DM174HN DN 17-(Cyclopropylmethyl)-N-phenylmorphinan-3-amine DM174HN MI TT27RFC DM174HN MN Opioid receptor delta (OPRD1) DM174HN MT DTT DM174HN MA Inhibitor DM174HN RN Synthesis and opioid receptor binding affinities of 2-substituted and 3-aminomorphinans: ligands for mu, kappa, and delta opioid receptors. J Med Chem. 2010 Jan 14;53(1):402-18. DM174HN RU https://pubmed.ncbi.nlm.nih.gov/19928862 DM174HN DI DM174HN DM174HN DN 17-(Cyclopropylmethyl)-N-phenylmorphinan-3-amine DM174HN MI TTQW87Y DM174HN MN Opioid receptor kappa (OPRK1) DM174HN MT DTT DM174HN MA Inhibitor DM174HN RN Synthesis and opioid receptor binding affinities of 2-substituted and 3-aminomorphinans: ligands for mu, kappa, and delta opioid receptors. J Med Chem. 2010 Jan 14;53(1):402-18. DM174HN RU https://pubmed.ncbi.nlm.nih.gov/19928862 DM174HN DI DM174HN DM174HN DN 17-(Cyclopropylmethyl)-N-phenylmorphinan-3-amine DM174HN MI TTKWM86 DM174HN MN Opioid receptor mu (MOP) DM174HN MT DTT DM174HN MA Inhibitor DM174HN RN Synthesis and opioid receptor binding affinities of 2-substituted and 3-aminomorphinans: ligands for mu, kappa, and delta opioid receptors. J Med Chem. 2010 Jan 14;53(1):402-18. DM174HN RU https://pubmed.ncbi.nlm.nih.gov/19928862 DMLC2VE DI DMLC2VE DMLC2VE DN 177Lu-labelled RM2 DMLC2VE MI TTC1MVT DMLC2VE MN Gastrin-releasing peptide receptor (GRPR) DMLC2VE MT DTT DMLC2VE MA Antagonist DMLC2VE RN Radiopharmaceutical therapy in cancer: clinical advances and challenges. Nat Rev Drug Discov. 2020 Sep;19(9):589-608. DMLC2VE RU https://pubmed.ncbi.nlm.nih.gov/32728208 DMT2EPG DI DMT2EPG DMT2EPG DN 17alpha-hydroxypregnenolone DMT2EPG MI DEN0GVQ DMT2EPG MN Beta-HSD adrenal and gonadal type (HSD3B2) DMT2EPG MT DME DMT2EPG MA Metabolism DMT2EPG RN Structure/function relationships responsible for the kinetic differences between human type 1 and type 2 3beta-hydroxysteroid dehydrogenase and for the catalysis of the type 1 activity. J Biol Chem. 2002 Nov 8;277(45):42795-801. DMT2EPG RU https://www.ncbi.nlm.nih.gov/pubmed/?term=12205101 DMT2EPG DI DMT2EPG DMT2EPG DN 17alpha-hydroxypregnenolone DMT2EPG MI DERDQWN DMT2EPG MN Dihydrotestosterone oxidoreductase (HSD3B1) DMT2EPG MT DME DMT2EPG MA Metabolism DMT2EPG RN Structure/function relationships responsible for the kinetic differences between human type 1 and type 2 3beta-hydroxysteroid dehydrogenase and for the catalysis of the type 1 activity. J Biol Chem. 2002 Nov 8;277(45):42795-801. DMT2EPG RU https://www.ncbi.nlm.nih.gov/pubmed/?term=12205101 DM7UHJS DI DM7UHJS DM7UHJS DN 17-dehydroxyriccardin C DM7UHJS MI TTECBXN DM7UHJS MN Oxysterols receptor LXR-alpha (NR1H3) DM7UHJS MT DTT DM7UHJS MA Inhibitor DM7UHJS RN Co-existence of alpha-glucosidase-inhibitory and liver X receptor-regulatory activities and their separation by structural development. Bioorg Med Chem. 2008 Apr 15;16(8):4272-85. DM7UHJS RU https://pubmed.ncbi.nlm.nih.gov/18343126 DM7UHJS DI DM7UHJS DM7UHJS DN 17-dehydroxyriccardin C DM7UHJS MI TTXA6PH DM7UHJS MN Oxysterols receptor LXR-beta (NR1H2) DM7UHJS MT DTT DM7UHJS MA Inhibitor DM7UHJS RN Co-existence of alpha-glucosidase-inhibitory and liver X receptor-regulatory activities and their separation by structural development. Bioorg Med Chem. 2008 Apr 15;16(8):4272-85. DM7UHJS RU https://pubmed.ncbi.nlm.nih.gov/18343126 DMCALYO DI DMCALYO DMCALYO DN 17-desmethoxy-17-aminogeldanamycin DMCALYO MI TT78R5H DMCALYO MN Heat shock protein 90 alpha (HSP90A) DMCALYO MT DTT DMCALYO MA Inhibitor DMCALYO RN Heat shock protein 90: inhibitors in clinical trials. J Med Chem. 2010 Jan 14;53(1):3-17. DMCALYO RU https://pubmed.ncbi.nlm.nih.gov/20055425 DMKUGH1 DI DMKUGH1 DMKUGH1 DN 17-METHYL-17-ALPHA-DIHYDROEQUILENIN DMKUGH1 MI TTZAYWL DMKUGH1 MN Estrogen receptor (ESR) DMKUGH1 MT DTT DMKUGH1 MA Inhibitor DMKUGH1 RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DMKUGH1 RU https://pubmed.ncbi.nlm.nih.gov/10592235 DMMEB64 DI DMMEB64 DMMEB64 DN 17-methyl-4'-methyldihydromorphinone DMMEB64 MI TT27RFC DMMEB64 MN Opioid receptor delta (OPRD1) DMMEB64 MT DTT DMMEB64 MA Inhibitor DMMEB64 RN Structural determinants of opioid activity in derivatives of 14-aminomorphinones: effect of substitution in the aromatic ring of cinnamoylaminomorp... J Med Chem. 2006 Aug 24;49(17):5333-8. DMMEB64 RU https://pubmed.ncbi.nlm.nih.gov/16913723 DMMEB64 DI DMMEB64 DMMEB64 DN 17-methyl-4'-methyldihydromorphinone DMMEB64 MI TTQW87Y DMMEB64 MN Opioid receptor kappa (OPRK1) DMMEB64 MT DTT DMMEB64 MA Inhibitor DMMEB64 RN Structural determinants of opioid activity in derivatives of 14-aminomorphinones: effect of substitution in the aromatic ring of cinnamoylaminomorp... J Med Chem. 2006 Aug 24;49(17):5333-8. DMMEB64 RU https://pubmed.ncbi.nlm.nih.gov/16913723 DMMEB64 DI DMMEB64 DMMEB64 DN 17-methyl-4'-methyldihydromorphinone DMMEB64 MI TTKWM86 DMMEB64 MN Opioid receptor mu (MOP) DMMEB64 MT DTT DMMEB64 MA Inhibitor DMMEB64 RN Structural determinants of opioid activity in derivatives of 14-aminomorphinones: effect of substitution in the aromatic ring of cinnamoylaminomorp... J Med Chem. 2006 Aug 24;49(17):5333-8. DMMEB64 RU https://pubmed.ncbi.nlm.nih.gov/16913723 DMI4WCQ DI DMI4WCQ DMI4WCQ DN 17-Methylmorphinan-3-yl 4-Iodophenyl Carbamate DMI4WCQ MI TT27RFC DMI4WCQ MN Opioid receptor delta (OPRD1) DMI4WCQ MT DTT DMI4WCQ MA Inhibitor DMI4WCQ RN Synthesis and opioid receptor binding affinities of 2-substituted and 3-aminomorphinans: ligands for mu, kappa, and delta opioid receptors. J Med Chem. 2010 Jan 14;53(1):402-18. DMI4WCQ RU https://pubmed.ncbi.nlm.nih.gov/19928862 DMI4WCQ DI DMI4WCQ DMI4WCQ DN 17-Methylmorphinan-3-yl 4-Iodophenyl Carbamate DMI4WCQ MI TTQW87Y DMI4WCQ MN Opioid receptor kappa (OPRK1) DMI4WCQ MT DTT DMI4WCQ MA Inhibitor DMI4WCQ RN Synthesis and opioid receptor binding affinities of 2-substituted and 3-aminomorphinans: ligands for mu, kappa, and delta opioid receptors. J Med Chem. 2010 Jan 14;53(1):402-18. DMI4WCQ RU https://pubmed.ncbi.nlm.nih.gov/19928862 DMI4WCQ DI DMI4WCQ DMI4WCQ DN 17-Methylmorphinan-3-yl 4-Iodophenyl Carbamate DMI4WCQ MI TTKWM86 DMI4WCQ MN Opioid receptor mu (MOP) DMI4WCQ MT DTT DMI4WCQ MA Inhibitor DMI4WCQ RN Synthesis and opioid receptor binding affinities of 2-substituted and 3-aminomorphinans: ligands for mu, kappa, and delta opioid receptors. J Med Chem. 2010 Jan 14;53(1):402-18. DMI4WCQ RU https://pubmed.ncbi.nlm.nih.gov/19928862 DM9OMI3 DI DM9OMI3 DM9OMI3 DN 17-phenyl-omega-trinor-PGE2 DM9OMI3 MI TTG1QMU DM9OMI3 MN Prostaglandin E2 receptor EP1 (PTGER1) DM9OMI3 MT DTT DM9OMI3 MA Agonist DM9OMI3 RN Molecular cloning and characterization of the four rat prostaglandin E2 prostanoid receptor subtypes. Eur J Pharmacol. 1997 Dec 11;340(2-3):227-41. DM9OMI3 RU https://pubmed.ncbi.nlm.nih.gov/9537820 DM9OMI3 DI DM9OMI3 DM9OMI3 DN 17-phenyl-omega-trinor-PGE2 DM9OMI3 MI TT1ZAVI DM9OMI3 MN Prostaglandin E2 receptor EP2 (PTGER2) DM9OMI3 MT DTT DM9OMI3 MA Agonist DM9OMI3 RN Molecular cloning and characterization of the four rat prostaglandin E2 prostanoid receptor subtypes. Eur J Pharmacol. 1997 Dec 11;340(2-3):227-41. DM9OMI3 RU https://pubmed.ncbi.nlm.nih.gov/9537820 DM9OMI3 DI DM9OMI3 DM9OMI3 DN 17-phenyl-omega-trinor-PGE2 DM9OMI3 MI TTPNGDE DM9OMI3 MN Prostaglandin E2 receptor EP3 (PTGER3) DM9OMI3 MT DTT DM9OMI3 MA Agonist DM9OMI3 RN Ligand binding specificities of the eight types and subtypes of the mouse prostanoid receptors expressed in Chinese hamster ovary cells. Br J Pharmacol. 1997 Sep;122(2):217-24. DM9OMI3 RU https://pubmed.ncbi.nlm.nih.gov/9313928 DMYS6DB DI DMYS6DB DMYS6DB DN 18alpha-Glycyrrhetic acid DMYS6DB MI TTELIN2 DMYS6DB MN PTPN1 messenger RNA (PTPN1 mRNA) DMYS6DB MT DTT DMYS6DB MA Inhibitor DMYS6DB RN Protein tyrosine phosphatase 1B inhibitory activity of triterpenes isolated from Astilbe koreana. Bioorg Med Chem Lett. 2006 Jun 15;16(12):3273-6. DMYS6DB RU https://pubmed.ncbi.nlm.nih.gov/16580200 DMFMRN8 DI DMFMRN8 DMFMRN8 DN 18beta-Glycyrrhetic acid DMFMRN8 MI TTELIN2 DMFMRN8 MN PTPN1 messenger RNA (PTPN1 mRNA) DMFMRN8 MT DTT DMFMRN8 MA Inhibitor DMFMRN8 RN Protein tyrosine phosphatase 1B inhibitory activity of triterpenes isolated from Astilbe koreana. Bioorg Med Chem Lett. 2006 Jun 15;16(12):3273-6. DMFMRN8 RU https://pubmed.ncbi.nlm.nih.gov/16580200 DM0JEQ6 DI DM0JEQ6 DM0JEQ6 DN 18-Dimethylaminocoronaridine DM0JEQ6 MI TTTVAFQ DM0JEQ6 MN Neuronal acetylcholine receptor beta-4 (CHRNB4) DM0JEQ6 MT DTT DM0JEQ6 MA Inhibitor DM0JEQ6 RN Synthesis and biological evaluation of 18-methoxycoronaridine congeners. Potential antiaddiction agents. J Med Chem. 2003 Jun 19;46(13):2716-30. DM0JEQ6 RU https://pubmed.ncbi.nlm.nih.gov/12801235 DMAPI2G DI DMAPI2G DMAPI2G DN 18F-AV-45 dimer DMAPI2G MI TTE4KHA DMAPI2G MN Amyloid beta A4 protein (APP) DMAPI2G MT DTT DMAPI2G MA Modulator DMAPI2G RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2402). DMAPI2G RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2402 DM2VZMC DI DM2VZMC DM2VZMC DN 18F-SMIBR-K5 DM2VZMC MI TT69TQN DM2VZMC MN Integrin alpha-V/beta-3 (ITGAV/B3) DM2VZMC MT DTT DM2VZMC MA Modulator DM2VZMC RN Synthesis of [18F]RGD-K5 by catalyzed [3 + 2] cycloaddition for imaging integrin alphavbeta3 expression in vivo. Nucl Med Biol. 2013 Jul;40(5):710-6. DM2VZMC RU https://pubmed.ncbi.nlm.nih.gov/23706550 DMBG9Z3 DI DMBG9Z3 DMBG9Z3 DN 18-methoxycoronaridinate 2-Hydroxyethylamide DMBG9Z3 MI TTTVAFQ DMBG9Z3 MN Neuronal acetylcholine receptor beta-4 (CHRNB4) DMBG9Z3 MT DTT DMBG9Z3 MA Inhibitor DMBG9Z3 RN Synthesis and biological evaluation of 18-methoxycoronaridine congeners. Potential antiaddiction agents. J Med Chem. 2003 Jun 19;46(13):2716-30. DMBG9Z3 RU https://pubmed.ncbi.nlm.nih.gov/12801235 DMSBAC0 DI DMSBAC0 DMSBAC0 DN 18-methoxycoronaridinate 2-methoxyethylamide DMSBAC0 MI TTTVAFQ DMSBAC0 MN Neuronal acetylcholine receptor beta-4 (CHRNB4) DMSBAC0 MT DTT DMSBAC0 MA Inhibitor DMSBAC0 RN Synthesis and biological evaluation of 18-methoxycoronaridine congeners. Potential antiaddiction agents. J Med Chem. 2003 Jun 19;46(13):2716-30. DMSBAC0 RU https://pubmed.ncbi.nlm.nih.gov/12801235 DMTJ384 DI DMTJ384 DMTJ384 DN 18-Methoxycoronaridine DMTJ384 MI TTMT0HG DMTJ384 MN Neuronal acetylcholine receptor alpha-2/alpha-3 (CHRNA2/A3) DMTJ384 MT DTT DMTJ384 MA Antagonist DMTJ384 RN Antagonism of alpha 3 beta 4 nicotinic receptors as a strategy to reduce opioid and stimulant self-administration. Eur J Pharmacol. 2002 Mar 1;438(1-2):99-105. DMTJ384 RU https://pubmed.ncbi.nlm.nih.gov/11906717 DMOYC0U DI DMOYC0U DMOYC0U DN 18-Methylaminocoronaridine DMOYC0U MI TTTVAFQ DMOYC0U MN Neuronal acetylcholine receptor beta-4 (CHRNB4) DMOYC0U MT DTT DMOYC0U MA Inhibitor DMOYC0U RN Synthesis and biological evaluation of 18-methoxycoronaridine congeners. Potential antiaddiction agents. J Med Chem. 2003 Jun 19;46(13):2716-30. DMOYC0U RU https://pubmed.ncbi.nlm.nih.gov/12801235 DMGUKCF DI DMGUKCF DMGUKCF DN 19(R)-OH-PGE2 DMGUKCF MI TT1ZAVI DMGUKCF MN Prostaglandin E2 receptor EP2 (PTGER2) DMGUKCF MT DTT DMGUKCF MA Agonist DMGUKCF RN Molecular cloning and characterization of the four rat prostaglandin E2 prostanoid receptor subtypes. Eur J Pharmacol. 1997 Dec 11;340(2-3):227-41. DMGUKCF RU https://pubmed.ncbi.nlm.nih.gov/9537820 DMGUKCF DI DMGUKCF DMGUKCF DN 19(R)-OH-PGE2 DMGUKCF MI TT79WV3 DMGUKCF MN Prostaglandin E2 receptor EP4 (PTGER4) DMGUKCF MT DTT DMGUKCF MA Agonist DMGUKCF RN Molecular cloning and characterization of the four rat prostaglandin E2 prostanoid receptor subtypes. Eur J Pharmacol. 1997 Dec 11;340(2-3):227-41. DMGUKCF RU https://pubmed.ncbi.nlm.nih.gov/9537820 DMP168O DI DMP168O DMP168O DN 19alpha,24-dihydroxyurs-12-en-3-on-28-oic acid DMP168O MI TTELIN2 DMP168O MN PTPN1 messenger RNA (PTPN1 mRNA) DMP168O MT DTT DMP168O MA Inhibitor DMP168O RN Triterpenoids from the leaves of Diospyros kaki (persimmon) and their inhibitory effects on protein tyrosine phosphatase 1B. J Nat Prod. 2008 Oct;71(10):1775-8. DMP168O RU https://pubmed.ncbi.nlm.nih.gov/18798681 DM92ZCU DI DM92ZCU DM92ZCU DN 1-acetamido-5-sulfonamidoindane DM92ZCU MI TTHQPL7 DM92ZCU MN Carbonic anhydrase I (CA-I) DM92ZCU MT DTT DM92ZCU MA Inhibitor DM92ZCU RN Carbonic anhydrase inhibitors. Design of anticonvulsant sulfonamides incorporating indane moieties. Bioorg Med Chem Lett. 2004 Dec 6;14(23):5781-6. DM92ZCU RU https://pubmed.ncbi.nlm.nih.gov/15501040 DM92ZCU DI DM92ZCU DM92ZCU DN 1-acetamido-5-sulfonamidoindane DM92ZCU MI TTANPDJ DM92ZCU MN Carbonic anhydrase II (CA-II) DM92ZCU MT DTT DM92ZCU MA Inhibitor DM92ZCU RN Indanesulfonamides as carbonic anhydrase inhibitors. Toward structure-based design of selective inhibitors of the tumor-associated isozyme CA IX. J Med Chem. 2006 May 4;49(9):2743-9. DM92ZCU RU https://pubmed.ncbi.nlm.nih.gov/16640335 DM92ZCU DI DM92ZCU DM92ZCU DN 1-acetamido-5-sulfonamidoindane DM92ZCU MI TT2LVK8 DM92ZCU MN Carbonic anhydrase IX (CA-IX) DM92ZCU MT DTT DM92ZCU MA Inhibitor DM92ZCU RN Indanesulfonamides as carbonic anhydrase inhibitors. Toward structure-based design of selective inhibitors of the tumor-associated isozyme CA IX. J Med Chem. 2006 May 4;49(9):2743-9. DM92ZCU RU https://pubmed.ncbi.nlm.nih.gov/16640335 DM7DL03 DI DM7DL03 DM7DL03 DN 1-Acetoxy-2-tert-butyldimethylsilyl-oxylycorine DM7DL03 MI TTXV4FI DM7DL03 MN Albendazole monooxygenase (CYP3A4) DM7DL03 MT DTT DM7DL03 MA Inhibitor DM7DL03 RN Selective cytochrome P450 3A4 inhibitory activity of Amaryllidaceae alkaloids. Bioorg Med Chem Lett. 2009 Jun 15;19(12):3233-7. DM7DL03 RU https://pubmed.ncbi.nlm.nih.gov/19428250 DMMP7HU DI DMMP7HU DMMP7HU DN 1'-acetoxychavicol acetate DMMP7HU MI TTELV3W DMMP7HU MN Transformation-sensitive protein p120 (TRPA1) DMMP7HU MT DTT DMMP7HU MA Activator DMMP7HU RN Galangal pungent component, 1'-acetoxychavicol acetate, activates TRPA1. Biosci Biotechnol Biochem. 2010;74(8):1694-6. DMMP7HU RU https://pubmed.ncbi.nlm.nih.gov/20699565 DMQH1MS DI DMQH1MS DMQH1MS DN 1-Acetoxylycorine DMQH1MS MI TTXV4FI DMQH1MS MN Albendazole monooxygenase (CYP3A4) DMQH1MS MT DTT DMQH1MS MA Inhibitor DMQH1MS RN Selective cytochrome P450 3A4 inhibitory activity of Amaryllidaceae alkaloids. Bioorg Med Chem Lett. 2009 Jun 15;19(12):3233-7. DMQH1MS RU https://pubmed.ncbi.nlm.nih.gov/19428250 DMRJSG7 DI DMRJSG7 DMRJSG7 DN 1-adamantan-1-yl-3-((R)-1-phenyl-ethyl)-urea DMRJSG7 MI TT7WVHI DMRJSG7 MN Soluble epoxide hydrolase (EPHX2) DMRJSG7 MT DTT DMRJSG7 MA Inhibitor DMRJSG7 RN Solid-phase combinatorial approach for the optimization of soluble epoxide hydrolase inhibitors. Bioorg Med Chem Lett. 2006 Nov 15;16(22):5773-7. DMRJSG7 RU https://pubmed.ncbi.nlm.nih.gov/16949285 DMNXU1O DI DMNXU1O DMNXU1O DN 1-adamantan-1-yl-3-(1-benzyl-piperidin-4-yl)-urea DMNXU1O MI TT7WVHI DMNXU1O MN Soluble epoxide hydrolase (EPHX2) DMNXU1O MT DTT DMNXU1O MA Inhibitor DMNXU1O RN Synthesis and SAR of conformationally restricted inhibitors of soluble epoxide hydrolase. Bioorg Med Chem Lett. 2006 Oct 1;16(19):5212-6. DMNXU1O RU https://pubmed.ncbi.nlm.nih.gov/16870439 DMAJC42 DI DMAJC42 DMAJC42 DN 1-adamantan-1-yl-3-(1-butyl-piperidin-4-yl)-urea DMAJC42 MI TT7WVHI DMAJC42 MN Soluble epoxide hydrolase (EPHX2) DMAJC42 MT DTT DMAJC42 MA Inhibitor DMAJC42 RN Synthesis and SAR of conformationally restricted inhibitors of soluble epoxide hydrolase. Bioorg Med Chem Lett. 2006 Oct 1;16(19):5212-6. DMAJC42 RU https://pubmed.ncbi.nlm.nih.gov/16870439 DMY1Z2X DI DMY1Z2X DMY1Z2X DN 1-adamantan-1-yl-3-(1-ethyl-piperidin-4-yl)-urea DMY1Z2X MI TT7WVHI DMY1Z2X MN Soluble epoxide hydrolase (EPHX2) DMY1Z2X MT DTT DMY1Z2X MA Inhibitor DMY1Z2X RN Synthesis and SAR of conformationally restricted inhibitors of soluble epoxide hydrolase. Bioorg Med Chem Lett. 2006 Oct 1;16(19):5212-6. DMY1Z2X RU https://pubmed.ncbi.nlm.nih.gov/16870439 DM2K7TX DI DM2K7TX DM2K7TX DN 1-adamantan-1-yl-3-(1-propyl-piperidin-4-yl)-urea DM2K7TX MI TT7WVHI DM2K7TX MN Soluble epoxide hydrolase (EPHX2) DM2K7TX MT DTT DM2K7TX MA Inhibitor DM2K7TX RN Synthesis and SAR of conformationally restricted inhibitors of soluble epoxide hydrolase. Bioorg Med Chem Lett. 2006 Oct 1;16(19):5212-6. DM2K7TX RU https://pubmed.ncbi.nlm.nih.gov/16870439 DMRIYX9 DI DMRIYX9 DMRIYX9 DN 1-adamantan-1-yl-3-(2-heptyloxyethyl)urea DMRIYX9 MI TT7WVHI DMRIYX9 MN Soluble epoxide hydrolase (EPHX2) DMRIYX9 MT DTT DMRIYX9 MA Inhibitor DMRIYX9 RN 1,3-disubstituted ureas functionalized with ether groups are potent inhibitors of the soluble epoxide hydrolase with improved pharmacokinetic prope... J Med Chem. 2007 Oct 18;50(21):5217-26. DMRIYX9 RU https://pubmed.ncbi.nlm.nih.gov/17894481 DMDO9YM DI DMDO9YM DMDO9YM DN 1-adamantan-1-yl-3-(2-hydroxyethyl)urea DMDO9YM MI TT7WVHI DMDO9YM MN Soluble epoxide hydrolase (EPHX2) DMDO9YM MT DTT DMDO9YM MA Inhibitor DMDO9YM RN 1,3-disubstituted ureas functionalized with ether groups are potent inhibitors of the soluble epoxide hydrolase with improved pharmacokinetic prope... J Med Chem. 2007 Oct 18;50(21):5217-26. DMDO9YM RU https://pubmed.ncbi.nlm.nih.gov/17894481 DMJ8ZS6 DI DMJ8ZS6 DMJ8ZS6 DN 1-Adamantan-1-yl-3-(2-hydroxy-phenyl)-urea DMJ8ZS6 MI TT7WVHI DMJ8ZS6 MN Soluble epoxide hydrolase (EPHX2) DMJ8ZS6 MT DTT DMJ8ZS6 MA Inhibitor DMJ8ZS6 RN Salicylate-urea-based soluble epoxide hydrolase inhibitors with high metabolic and chemical stabilities. Bioorg Med Chem Lett. 2009 Mar 15;19(6):1784-9. DMJ8ZS6 RU https://pubmed.ncbi.nlm.nih.gov/19216074 DMRBVFO DI DMRBVFO DMRBVFO DN 1-Adamantan-1-yl-3-(2-methoxy-phenyl)-urea DMRBVFO MI TT7WVHI DMRBVFO MN Soluble epoxide hydrolase (EPHX2) DMRBVFO MT DTT DMRBVFO MA Inhibitor DMRBVFO RN Salicylate-urea-based soluble epoxide hydrolase inhibitors with high metabolic and chemical stabilities. Bioorg Med Chem Lett. 2009 Mar 15;19(6):1784-9. DMRBVFO RU https://pubmed.ncbi.nlm.nih.gov/19216074 DMGEXOZ DI DMGEXOZ DMGEXOZ DN 1-adamantan-1-yl-3-(3-hexyloxypropyl)urea DMGEXOZ MI TT7WVHI DMGEXOZ MN Soluble epoxide hydrolase (EPHX2) DMGEXOZ MT DTT DMGEXOZ MA Inhibitor DMGEXOZ RN 1,3-disubstituted ureas functionalized with ether groups are potent inhibitors of the soluble epoxide hydrolase with improved pharmacokinetic prope... J Med Chem. 2007 Oct 18;50(21):5217-26. DMGEXOZ RU https://pubmed.ncbi.nlm.nih.gov/17894481 DM8SEJP DI DM8SEJP DM8SEJP DN 1-Adamantan-1-yl-3-(3-hydroxy-phenyl)-urea DM8SEJP MI TT7WVHI DM8SEJP MN Soluble epoxide hydrolase (EPHX2) DM8SEJP MT DTT DM8SEJP MA Inhibitor DM8SEJP RN Salicylate-urea-based soluble epoxide hydrolase inhibitors with high metabolic and chemical stabilities. Bioorg Med Chem Lett. 2009 Mar 15;19(6):1784-9. DM8SEJP RU https://pubmed.ncbi.nlm.nih.gov/19216074 DMZX72E DI DMZX72E DMZX72E DN 1-adamantan-1-yl-3-(3-hydroxypropyl)urea DMZX72E MI TT7WVHI DMZX72E MN Soluble epoxide hydrolase (EPHX2) DMZX72E MT DTT DMZX72E MA Inhibitor DMZX72E RN 1,3-disubstituted ureas functionalized with ether groups are potent inhibitors of the soluble epoxide hydrolase with improved pharmacokinetic prope... J Med Chem. 2007 Oct 18;50(21):5217-26. DMZX72E RU https://pubmed.ncbi.nlm.nih.gov/17894481 DMHAS3G DI DMHAS3G DMHAS3G DN 1-Adamantan-1-yl-3-(3-methoxy-phenyl)-urea DMHAS3G MI TT7WVHI DMHAS3G MN Soluble epoxide hydrolase (EPHX2) DMHAS3G MT DTT DMHAS3G MA Inhibitor DMHAS3G RN Salicylate-urea-based soluble epoxide hydrolase inhibitors with high metabolic and chemical stabilities. Bioorg Med Chem Lett. 2009 Mar 15;19(6):1784-9. DMHAS3G RU https://pubmed.ncbi.nlm.nih.gov/19216074 DM53G1V DI DM53G1V DM53G1V DN 1-adamantan-1-yl-3-(4-hydroxybutyl)urea DM53G1V MI TT7WVHI DM53G1V MN Soluble epoxide hydrolase (EPHX2) DM53G1V MT DTT DM53G1V MA Inhibitor DM53G1V RN 1,3-disubstituted ureas functionalized with ether groups are potent inhibitors of the soluble epoxide hydrolase with improved pharmacokinetic prope... J Med Chem. 2007 Oct 18;50(21):5217-26. DM53G1V RU https://pubmed.ncbi.nlm.nih.gov/17894481 DMHKG89 DI DMHKG89 DMHKG89 DN 1-Adamantan-1-yl-3-(4-hydroxy-decyl)-urea DMHKG89 MI TT7WVHI DMHKG89 MN Soluble epoxide hydrolase (EPHX2) DMHKG89 MT DTT DMHKG89 MA Inhibitor DMHKG89 RN Optimization of amide-based inhibitors of soluble epoxide hydrolase with improved water solubility. J Med Chem. 2005 May 19;48(10):3621-9. DMHKG89 RU https://pubmed.ncbi.nlm.nih.gov/15887969 DMUPAR1 DI DMUPAR1 DMUPAR1 DN 1-Adamantan-1-yl-3-(4-hydroxy-phenyl)-urea DMUPAR1 MI TT7WVHI DMUPAR1 MN Soluble epoxide hydrolase (EPHX2) DMUPAR1 MT DTT DMUPAR1 MA Inhibitor DMUPAR1 RN Salicylate-urea-based soluble epoxide hydrolase inhibitors with high metabolic and chemical stabilities. Bioorg Med Chem Lett. 2009 Mar 15;19(6):1784-9. DMUPAR1 RU https://pubmed.ncbi.nlm.nih.gov/19216074 DMMBYOD DI DMMBYOD DMMBYOD DN 1-Adamantan-1-yl-3-(4-methoxy-phenyl)-urea DMMBYOD MI TT7WVHI DMMBYOD MN Soluble epoxide hydrolase (EPHX2) DMMBYOD MT DTT DMMBYOD MA Inhibitor DMMBYOD RN Salicylate-urea-based soluble epoxide hydrolase inhibitors with high metabolic and chemical stabilities. Bioorg Med Chem Lett. 2009 Mar 15;19(6):1784-9. DMMBYOD RU https://pubmed.ncbi.nlm.nih.gov/19216074 DM3RE2D DI DM3RE2D DM3RE2D DN 1-adamantan-1-yl-3-(4-pentyloxybutyl)urea DM3RE2D MI TT7WVHI DM3RE2D MN Soluble epoxide hydrolase (EPHX2) DM3RE2D MT DTT DM3RE2D MA Inhibitor DM3RE2D RN 1,3-disubstituted ureas functionalized with ether groups are potent inhibitors of the soluble epoxide hydrolase with improved pharmacokinetic prope... J Med Chem. 2007 Oct 18;50(21):5217-26. DM3RE2D RU https://pubmed.ncbi.nlm.nih.gov/17894481 DMUZ3OS DI DMUZ3OS DMUZ3OS DN 1-adamantan-1-yl-3-(4-pentyloxycylclohexyl)urea DMUZ3OS MI TT7WVHI DMUZ3OS MN Soluble epoxide hydrolase (EPHX2) DMUZ3OS MT DTT DMUZ3OS MA Inhibitor DMUZ3OS RN 1,3-disubstituted ureas functionalized with ether groups are potent inhibitors of the soluble epoxide hydrolase with improved pharmacokinetic prope... J Med Chem. 2007 Oct 18;50(21):5217-26. DMUZ3OS RU https://pubmed.ncbi.nlm.nih.gov/17894481 DMEDQVX DI DMEDQVX DMEDQVX DN 1-adamantan-1-yl-3-(5-butoxypentyl)urea DMEDQVX MI TT7WVHI DMEDQVX MN Soluble epoxide hydrolase (EPHX2) DMEDQVX MT DTT DMEDQVX MA Inhibitor DMEDQVX RN 1,3-disubstituted ureas functionalized with ether groups are potent inhibitors of the soluble epoxide hydrolase with improved pharmacokinetic prope... J Med Chem. 2007 Oct 18;50(21):5217-26. DMEDQVX RU https://pubmed.ncbi.nlm.nih.gov/17894481 DMV6824 DI DMV6824 DMV6824 DN 1-adamantan-1-yl-3-(5-hydroxypentyl)urea DMV6824 MI TT7WVHI DMV6824 MN Soluble epoxide hydrolase (EPHX2) DMV6824 MT DTT DMV6824 MA Inhibitor DMV6824 RN 1,3-disubstituted ureas functionalized with ether groups are potent inhibitors of the soluble epoxide hydrolase with improved pharmacokinetic prope... J Med Chem. 2007 Oct 18;50(21):5217-26. DMV6824 RU https://pubmed.ncbi.nlm.nih.gov/17894481 DMOX5MC DI DMOX5MC DMOX5MC DN 1-adamantan-1-yl-3-(6-hydroxyhexyl)urea DMOX5MC MI TT7WVHI DMOX5MC MN Soluble epoxide hydrolase (EPHX2) DMOX5MC MT DTT DMOX5MC MA Inhibitor DMOX5MC RN 1,3-disubstituted ureas functionalized with ether groups are potent inhibitors of the soluble epoxide hydrolase with improved pharmacokinetic prope... J Med Chem. 2007 Oct 18;50(21):5217-26. DMOX5MC RU https://pubmed.ncbi.nlm.nih.gov/17894481 DMO1L3I DI DMO1L3I DMO1L3I DN 1-adamantan-1-yl-3-(6-propyloxyhexyl)urea DMO1L3I MI TT7WVHI DMO1L3I MN Soluble epoxide hydrolase (EPHX2) DMO1L3I MT DTT DMO1L3I MA Inhibitor DMO1L3I RN 1,3-disubstituted ureas functionalized with ether groups are potent inhibitors of the soluble epoxide hydrolase with improved pharmacokinetic prope... J Med Chem. 2007 Oct 18;50(21):5217-26. DMO1L3I RU https://pubmed.ncbi.nlm.nih.gov/17894481 DMXRHKQ DI DMXRHKQ DMXRHKQ DN 1-adamantan-1-yl-3-[4-(4-fluorophenoxy)butyl]urea DMXRHKQ MI TT7WVHI DMXRHKQ MN Soluble epoxide hydrolase (EPHX2) DMXRHKQ MT DTT DMXRHKQ MA Inhibitor DMXRHKQ RN Orally bioavailable potent soluble epoxide hydrolase inhibitors. J Med Chem. 2007 Aug 9;50(16):3825-40. DMXRHKQ RU https://pubmed.ncbi.nlm.nih.gov/17616115 DMLD2G3 DI DMLD2G3 DMLD2G3 DN 1-Adamantan-1-yl-3-decyl-urea DMLD2G3 MI TT7WVHI DMLD2G3 MN Soluble epoxide hydrolase (EPHX2) DMLD2G3 MT DTT DMLD2G3 MA Inhibitor DMLD2G3 RN Optimization of amide-based inhibitors of soluble epoxide hydrolase with improved water solubility. J Med Chem. 2005 May 19;48(10):3621-9. DMLD2G3 RU https://pubmed.ncbi.nlm.nih.gov/15887969 DMCFKX0 DI DMCFKX0 DMCFKX0 DN 1-Adamantan-1-yl-3-phenyl-urea DMCFKX0 MI TT7WVHI DMCFKX0 MN Soluble epoxide hydrolase (EPHX2) DMCFKX0 MT DTT DMCFKX0 MA Inhibitor DMCFKX0 RN Salicylate-urea-based soluble epoxide hydrolase inhibitors with high metabolic and chemical stabilities. Bioorg Med Chem Lett. 2009 Mar 15;19(6):1784-9. DMCFKX0 RU https://pubmed.ncbi.nlm.nih.gov/19216074 DMGPIL0 DI DMGPIL0 DMGPIL0 DN 1-adamantan-1-yl-3-piperidin-4-ylmethyl-urea DMGPIL0 MI TT7WVHI DMGPIL0 MN Soluble epoxide hydrolase (EPHX2) DMGPIL0 MT DTT DMGPIL0 MA Inhibitor DMGPIL0 RN Synthesis and SAR of conformationally restricted inhibitors of soluble epoxide hydrolase. Bioorg Med Chem Lett. 2006 Oct 1;16(19):5212-6. DMGPIL0 RU https://pubmed.ncbi.nlm.nih.gov/16870439 DMTNPBH DI DMTNPBH DMTNPBH DN 1-adamantan-1-yl-3-piperidin-4-yl-urea DMTNPBH MI TT7WVHI DMTNPBH MN Soluble epoxide hydrolase (EPHX2) DMTNPBH MT DTT DMTNPBH MA Inhibitor DMTNPBH RN Synthesis and SAR of conformationally restricted inhibitors of soluble epoxide hydrolase. Bioorg Med Chem Lett. 2006 Oct 1;16(19):5212-6. DMTNPBH RU https://pubmed.ncbi.nlm.nih.gov/16870439 DM60Y8M DI DM60Y8M DM60Y8M DN 1-Adamantan-1-ylmethyl-3-thiazol-2-yl-thiourea DM60Y8M MI TT84ETX DM60Y8M MN Human immunodeficiency virus Reverse transcriptase (HIV RT) DM60Y8M MT DTT DM60Y8M MA Inhibitor DM60Y8M RN Anti-HIV activity of aromatic and heterocyclic thiazolyl thiourea compounds. Bioorg Med Chem Lett. 2001 Feb 26;11(4):523-8. DM60Y8M RU https://pubmed.ncbi.nlm.nih.gov/11229762 DMQJ9RZ DI DMQJ9RZ DMQJ9RZ DN 1-allyl-2-[3-(isopropylamino)propoxy]-9H-carbazole DMQJ9RZ MI TTFQEO5 DMQJ9RZ MN Squalene synthetase (FDFT1) DMQJ9RZ MT DTT DMQJ9RZ MA Inhibitor DMQJ9RZ RN Synthesis and biological evaluation of novel propylamine derivatives as orally active squalene synthase inhibitors. Bioorg Med Chem. 2004 Nov 15;12(22):5899-908. DMQJ9RZ RU https://pubmed.ncbi.nlm.nih.gov/15498666 DMNDW4J DI DMNDW4J DMNDW4J DN 1-allyl-2-[3-(isopropylamino)propoxy]-9H-xanthen-9-one DMNDW4J MI TTFQEO5 DMNDW4J MN Squalene synthetase (FDFT1) DMNDW4J MT DTT DMNDW4J MA Inhibitor DMNDW4J RN Synthesis and biological evaluation of novel propylamine derivatives as orally active squalene synthase inhibitors. Bioorg Med Chem. 2004 Nov 15;12(22):5899-908. DMNDW4J RU https://pubmed.ncbi.nlm.nih.gov/15498666 DML54H2 DI DML54H2 DML54H2 DN 1-Allyl-3,7-dihydro-purine-2,6-dione DML54H2 MI TTJFY5U DML54H2 MN Adenosine A3 receptor (ADORA3) DML54H2 MT DTT DML54H2 MA Inhibitor DML54H2 RN Structure-activity relationships at human and rat A2B adenosine receptors of xanthine derivatives substituted at the 1-, 3-, 7-, and 8-positions. J Med Chem. 2002 May 23;45(11):2131-8. DML54H2 RU https://pubmed.ncbi.nlm.nih.gov/12014951 DMZE5GX DI DMZE5GX DMZE5GX DN 1-Allyl-3,7-dimethyl-3,7-dihydro-purine-2,6-dione DMZE5GX MI TTM2AOE DMZE5GX MN Adenosine A2a receptor (ADORA2A) DMZE5GX MT DTT DMZE5GX MA Inhibitor DMZE5GX RN Analogues of caffeine and theophylline: effect of structural alterations on affinity at adenosine receptors. J Med Chem. 1986 Jul;29(7):1305-8. DMZE5GX RU https://pubmed.ncbi.nlm.nih.gov/3806581 DM2J5WH DI DM2J5WH DM2J5WH DN 1-allyl-5'-O-tritylinosine DM2J5WH MI TTO0IB8 DM2J5WH MN Thymidine phosphorylase (TYMP) DM2J5WH MT DTT DM2J5WH MA Inhibitor DM2J5WH RN 5'-O-tritylinosine and analogues as allosteric inhibitors of human thymidine phosphorylase. J Med Chem. 2006 Sep 7;49(18):5562-70. DM2J5WH RU https://pubmed.ncbi.nlm.nih.gov/16942029 DMRAN9T DI DMRAN9T DMRAN9T DN 1-amino-2,4-bis(phenylthio)anthracene-9,10-dione DMRAN9T MI TTM2AOE DMRAN9T MN Adenosine A2a receptor (ADORA2A) DMRAN9T MT DTT DMRAN9T MA Inhibitor DMRAN9T RN Structure-based discovery of novel chemotypes for adenosine A(2A) receptor antagonists. J Med Chem. 2010 Feb 25;53(4):1799-809. DMRAN9T RU https://pubmed.ncbi.nlm.nih.gov/20095623 DMWCXM4 DI DMWCXM4 DMWCXM4 DN 1-amino-2-phenoxyanthracene-9,10-dione DMWCXM4 MI TTM2AOE DMWCXM4 MN Adenosine A2a receptor (ADORA2A) DMWCXM4 MT DTT DMWCXM4 MA Inhibitor DMWCXM4 RN Structure-based discovery of novel chemotypes for adenosine A(2A) receptor antagonists. J Med Chem. 2010 Feb 25;53(4):1799-809. DMWCXM4 RU https://pubmed.ncbi.nlm.nih.gov/20095623 DMOAQC4 DI DMOAQC4 DMOAQC4 DN 1-Amino-3-(aminoxy)-2-propanol Dihydrochloride DMOAQC4 MI TTUMGNO DMOAQC4 MN Ornithine decarboxylase (ODC1) DMOAQC4 MT DTT DMOAQC4 MA Inhibitor DMOAQC4 RN Selective delivery of 2-hydroxy APA to Trypanosoma brucei using the melamine motif. Bioorg Med Chem Lett. 2010 Aug 1;20(15):4364-6. DMOAQC4 RU https://pubmed.ncbi.nlm.nih.gov/20615694 DMJMDNX DI DMJMDNX DMJMDNX DN 1-amino-4-chloroanthracene-9,10-dione DMJMDNX MI TTM2AOE DMJMDNX MN Adenosine A2a receptor (ADORA2A) DMJMDNX MT DTT DMJMDNX MA Inhibitor DMJMDNX RN Structure-based discovery of novel chemotypes for adenosine A(2A) receptor antagonists. J Med Chem. 2010 Feb 25;53(4):1799-809. DMJMDNX RU https://pubmed.ncbi.nlm.nih.gov/20095623 DM7X5BP DI DM7X5BP DM7X5BP DN 1-amino-4-methoxyanthracene-9,10-dione DM7X5BP MI TTM2AOE DM7X5BP MN Adenosine A2a receptor (ADORA2A) DM7X5BP MT DTT DM7X5BP MA Inhibitor DM7X5BP RN Structure-based discovery of novel chemotypes for adenosine A(2A) receptor antagonists. J Med Chem. 2010 Feb 25;53(4):1799-809. DM7X5BP RU https://pubmed.ncbi.nlm.nih.gov/20095623 DM6AV2S DI DM6AV2S DM6AV2S DN 1-Amino-6-Cyclohex-3-Enylmethyloxypurine DM6AV2S MI TT7HF4W DM6AV2S MN Cyclin-dependent kinase 2 (CDK2) DM6AV2S MT DTT DM6AV2S MA Inhibitor DM6AV2S RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DM6AV2S RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMGU76I DI DMGU76I DMGU76I DN 1-aminoanthracene-9,10-dione DMGU76I MI TTM2AOE DMGU76I MN Adenosine A2a receptor (ADORA2A) DMGU76I MT DTT DMGU76I MA Inhibitor DMGU76I RN Structure-based discovery of novel chemotypes for adenosine A(2A) receptor antagonists. J Med Chem. 2010 Feb 25;53(4):1799-809. DMGU76I RU https://pubmed.ncbi.nlm.nih.gov/20095623 DM4TFN6 DI DM4TFN6 DM4TFN6 DN 1-aminobutylphosphonic acid DM4TFN6 MI TTPHMWB DM4TFN6 MN Aminopeptidase N (ANPEP) DM4TFN6 MT DTT DM4TFN6 MA Inhibitor DM4TFN6 RN New aromatic monoesters of alpha-aminoaralkylphosphonic acids as inhibitors of aminopeptidase N/CD13. Bioorg Med Chem. 2010 Apr 15;18(8):2930-6. DM4TFN6 RU https://pubmed.ncbi.nlm.nih.gov/20347318 DMFUABI DI DMFUABI DMFUABI DN 1-aminohexylphosphonic acid DMFUABI MI TTPHMWB DMFUABI MN Aminopeptidase N (ANPEP) DMFUABI MT DTT DMFUABI MA Inhibitor DMFUABI RN New aromatic monoesters of alpha-aminoaralkylphosphonic acids as inhibitors of aminopeptidase N/CD13. Bioorg Med Chem. 2010 Apr 15;18(8):2930-6. DMFUABI RU https://pubmed.ncbi.nlm.nih.gov/20347318 DML6UJM DI DML6UJM DML6UJM DN 1-aminohexylphosphonic acid monophenyl ester DML6UJM MI TTPHMWB DML6UJM MN Aminopeptidase N (ANPEP) DML6UJM MT DTT DML6UJM MA Inhibitor DML6UJM RN New aromatic monoesters of alpha-aminoaralkylphosphonic acids as inhibitors of aminopeptidase N/CD13. Bioorg Med Chem. 2010 Apr 15;18(8):2930-6. DML6UJM RU https://pubmed.ncbi.nlm.nih.gov/20347318 DMBWNL6 DI DMBWNL6 DMBWNL6 DN 1-Aminomethyl-3-cyclohexyl-isochroman-5,6-diol DMBWNL6 MI TTZFYLI DMBWNL6 MN Dopamine D1 receptor (D1R) DMBWNL6 MT DTT DMBWNL6 MA Inhibitor DMBWNL6 RN Synthesis and pharmacological evaluation of 1-(aminomethyl)-3,4-dihydro-5-hydroxy-1H-2-benzopyrans as dopamine D1 selective ligands. J Med Chem. 1991 Oct;34(10):2946-53. DMBWNL6 RU https://pubmed.ncbi.nlm.nih.gov/1833546 DMBWNL6 DI DMBWNL6 DMBWNL6 DN 1-Aminomethyl-3-cyclohexyl-isochroman-5,6-diol DMBWNL6 MI TTEX248 DMBWNL6 MN Dopamine D2 receptor (D2R) DMBWNL6 MT DTT DMBWNL6 MA Inhibitor DMBWNL6 RN Synthesis and pharmacological evaluation of 1-(aminomethyl)-3,4-dihydro-5-hydroxy-1H-2-benzopyrans as dopamine D1 selective ligands. J Med Chem. 1991 Oct;34(10):2946-53. DMBWNL6 RU https://pubmed.ncbi.nlm.nih.gov/1833546 DMJNG8A DI DMJNG8A DMJNG8A DN 1-Aminomethyl-3-phenyl-isochroman-5,6-diol DMJNG8A MI TTZFYLI DMJNG8A MN Dopamine D1 receptor (D1R) DMJNG8A MT DTT DMJNG8A MA Inhibitor DMJNG8A RN (1R,3S)-1-(aminomethyl)-3,4-dihydro-5,6-dihydroxy-3-phenyl-1H-2-benzopyran: a potent and selective D1 agonist. J Med Chem. 1990 Nov;33(11):2948-50. DMJNG8A RU https://pubmed.ncbi.nlm.nih.gov/1977907 DM50GS7 DI DM50GS7 DM50GS7 DN 1-Aminomethyl-isochroman-5,6-diol DM50GS7 MI TTZFYLI DM50GS7 MN Dopamine D1 receptor (D1R) DM50GS7 MT DTT DM50GS7 MA Inhibitor DM50GS7 RN (1R,3S)-1-(aminomethyl)-3,4-dihydro-5,6-dihydroxy-3-phenyl-1H-2-benzopyran: a potent and selective D1 agonist. J Med Chem. 1990 Nov;33(11):2948-50. DM50GS7 RU https://pubmed.ncbi.nlm.nih.gov/1977907 DM50GS7 DI DM50GS7 DM50GS7 DN 1-Aminomethyl-isochroman-5,6-diol DM50GS7 MI TTEX248 DM50GS7 MN Dopamine D2 receptor (D2R) DM50GS7 MT DTT DM50GS7 MA Inhibitor DM50GS7 RN (1R,3S)-1-(aminomethyl)-3,4-dihydro-5,6-dihydroxy-3-phenyl-1H-2-benzopyran: a potent and selective D1 agonist. J Med Chem. 1990 Nov;33(11):2948-50. DM50GS7 RU https://pubmed.ncbi.nlm.nih.gov/1977907 DMMV30B DI DMMV30B DMMV30B DN 1-aminopentylphosphonic acid monophenyl ester DMMV30B MI TTPHMWB DMMV30B MN Aminopeptidase N (ANPEP) DMMV30B MT DTT DMMV30B MA Inhibitor DMMV30B RN New aromatic monoesters of alpha-aminoaralkylphosphonic acids as inhibitors of aminopeptidase N/CD13. Bioorg Med Chem. 2010 Apr 15;18(8):2930-6. DMMV30B RU https://pubmed.ncbi.nlm.nih.gov/20347318 DMPYCK5 DI DMPYCK5 DMPYCK5 DN 1-Aminopropane-1,2,3-tricarboxylic acid DMPYCK5 MI TTHI19T DMPYCK5 MN Staphylococcus Beta-lactamase (Stap-coc blaZ) DMPYCK5 MT DTT DMPYCK5 MA Inhibitor DMPYCK5 RN Discovery of novel lipophilic inhibitors of OXA-10 enzyme (class D beta-lactamase) by screening amino analogs and homologs of citrate and isocitrate. Bioorg Med Chem Lett. 2009 Jul 1;19(13):3593-7. DMPYCK5 RU https://pubmed.ncbi.nlm.nih.gov/19467869 DMNGY0E DI DMNGY0E DMNGY0E DN 1-anilinonaphthalene-8-sulfonic acid DMNGY0E MI TTIV96N DMNGY0E MN Fatty acid-binding protein 1 (FABP1) DMNGY0E MT DTT DMNGY0E MA Inhibitor DMNGY0E RN Characterization of the drug binding specificity of rat liver fatty acid binding protein. J Med Chem. 2008 Jul 10;51(13):3755-64. DMNGY0E RU https://pubmed.ncbi.nlm.nih.gov/18533710 DMJD1QF DI DMJD1QF DMJD1QF DN 1-arylmethylpyrrolidin-2-yl ethanol amine DMJD1QF MI TTBUYHA DMJD1QF MN Extracellular calcium-sensing receptor (CASR) DMJD1QF MT DTT DMJD1QF MA Antagonist DMJD1QF RN Discovery of novel 1-arylmethyl pyrrolidin-2-yl ethanol amines as calcium-sensing receptor antagonists. Bioorg Med Chem Lett. 2005 Dec 15;15(24):5478-82. DMJD1QF RU https://pubmed.ncbi.nlm.nih.gov/16216508 DMQ1EVT DI DMQ1EVT DMQ1EVT DN 1-benzene sulfonyl-cis-2,6-dimethyl piperidine DMQ1EVT MI TT1RS9F DMQ1EVT MN Acetylcholinesterase (AChE) DMQ1EVT MT DTT DMQ1EVT MA Inhibitor DMQ1EVT RN Active site directed docking studies: synthesis and pharmacological evaluation of cis-2,6-dimethyl piperidine sulfonamides as inhibitors of acetylc... Eur J Med Chem. 2009 Oct;44(10):4057-62. DMQ1EVT RU https://pubmed.ncbi.nlm.nih.gov/19493592 DM781L6 DI DM781L6 DM781L6 DN 1-Benzenesulfonyl-2-nitro-benzene DM781L6 MI TT84ETX DM781L6 MN Human immunodeficiency virus Reverse transcriptase (HIV RT) DM781L6 MT DTT DM781L6 MA Inhibitor DM781L6 RN 2-Amino-6-arylsulfonylbenzonitriles as non-nucleoside reverse transcriptase inhibitors of HIV-1. J Med Chem. 2001 Jun 7;44(12):1866-82. DM781L6 RU https://pubmed.ncbi.nlm.nih.gov/11384233 DM1N4LK DI DM1N4LK DM1N4LK DN 1-Benzenesulfonyl-3-piperidin-3-yl-1H-indole DM1N4LK MI TTJS8PY DM1N4LK MN 5-HT 6 receptor (HTR6) DM1N4LK MT DTT DM1N4LK MA Inhibitor DM1N4LK RN Conformationally constrained N1-arylsulfonyltryptamine derivatives as 5-HT6 receptor antagonists. Bioorg Med Chem Lett. 2005 Nov 1;15(21):4780-5. DM1N4LK RU https://pubmed.ncbi.nlm.nih.gov/16125933 DMRA9VG DI DMRA9VG DMRA9VG DN 1-Benzenesulfonyl-3-piperidin-4-yl-1H-indole DMRA9VG MI TTJS8PY DMRA9VG MN 5-HT 6 receptor (HTR6) DMRA9VG MT DTT DMRA9VG MA Inhibitor DMRA9VG RN N1-arylsulfonyl-3-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indole derivatives are potent and selective 5-HT6 receptor antagonists. Bioorg Med Chem Lett. 2005 Jan 17;15(2):379-83. DMRA9VG RU https://pubmed.ncbi.nlm.nih.gov/15603958 DMQSK3H DI DMQSK3H DMQSK3H DN 1-benzhydryl-3-(isoquinolin-5-yl)urea DMQSK3H MI TTMI6F5 DMQSK3H MN Transient receptor potential cation channel V1 (TRPV1) DMQSK3H MT DTT DMQSK3H MA Inhibitor DMQSK3H RN Alpha-methylation at benzylic fragment of N-aryl-N'-benzyl ureas provides TRPV1 antagonists with better pharmacokinetic properties and higher effic... Bioorg Med Chem Lett. 2007 Jul 15;17(14):3894-9. DMQSK3H RU https://pubmed.ncbi.nlm.nih.gov/17507218 DMBAZG3 DI DMBAZG3 DMBAZG3 DN 1-benzhydryl-3-butylpiperidin-4-amine DMBAZG3 MI TTDIGC1 DMBAZG3 MN Dipeptidyl peptidase 4 (DPP-4) DMBAZG3 MT DTT DMBAZG3 MA Inhibitor DMBAZG3 RN 1,3-disubstituted 4-aminopiperidines as useful tools in the optimization of the 2-aminobenzo[a]quinolizine dipeptidyl peptidase IV inhibitors. Bioorg Med Chem Lett. 2007 Jun 1;17(11):2966-70. DMBAZG3 RU https://pubmed.ncbi.nlm.nih.gov/17418568 DMTANPG DI DMTANPG DMTANPG DN 1-benzhydryl-4-(2-fluorophenyl)piperidin-4-ol DMTANPG MI TTNT7K8 DMTANPG MN Nociceptin receptor (OPRL1) DMTANPG MT DTT DMTANPG MA Inhibitor DMTANPG RN Bioorg Med Chem Lett. 2007 Jun 1;17(11):3028-33. Epub 2007 Mar 21.Synthesis and structure-activity relationships of 4-hydroxy-4-phenylpiperidines as nociceptin receptor ligands: Part 2. DMTANPG RU https://pubmed.ncbi.nlm.nih.gov/17420123 DMTANPG DI DMTANPG DMTANPG DN 1-benzhydryl-4-(2-fluorophenyl)piperidin-4-ol DMTANPG MI TT27RFC DMTANPG MN Opioid receptor delta (OPRD1) DMTANPG MT DTT DMTANPG MA Inhibitor DMTANPG RN Bioorg Med Chem Lett. 2007 Jun 1;17(11):3028-33. Epub 2007 Mar 21.Synthesis and structure-activity relationships of 4-hydroxy-4-phenylpiperidines as nociceptin receptor ligands: Part 2. DMTANPG RU https://pubmed.ncbi.nlm.nih.gov/17420123 DMTANPG DI DMTANPG DMTANPG DN 1-benzhydryl-4-(2-fluorophenyl)piperidin-4-ol DMTANPG MI TTQW87Y DMTANPG MN Opioid receptor kappa (OPRK1) DMTANPG MT DTT DMTANPG MA Inhibitor DMTANPG RN Bioorg Med Chem Lett. 2007 Jun 1;17(11):3028-33. Epub 2007 Mar 21.Synthesis and structure-activity relationships of 4-hydroxy-4-phenylpiperidines as nociceptin receptor ligands: Part 2. DMTANPG RU https://pubmed.ncbi.nlm.nih.gov/17420123 DMTANPG DI DMTANPG DMTANPG DN 1-benzhydryl-4-(2-fluorophenyl)piperidin-4-ol DMTANPG MI TTKWM86 DMTANPG MN Opioid receptor mu (MOP) DMTANPG MT DTT DMTANPG MA Inhibitor DMTANPG RN Bioorg Med Chem Lett. 2007 Jun 1;17(11):3028-33. Epub 2007 Mar 21.Synthesis and structure-activity relationships of 4-hydroxy-4-phenylpiperidines as nociceptin receptor ligands: Part 2. DMTANPG RU https://pubmed.ncbi.nlm.nih.gov/17420123 DMWHMNY DI DMWHMNY DMWHMNY DN 1-benzhydryl-4-(2-methoxyphenyl)piperidin-4-ol DMWHMNY MI TTNT7K8 DMWHMNY MN Nociceptin receptor (OPRL1) DMWHMNY MT DTT DMWHMNY MA Inhibitor DMWHMNY RN Bioorg Med Chem Lett. 2007 Jun 1;17(11):3028-33. Epub 2007 Mar 21.Synthesis and structure-activity relationships of 4-hydroxy-4-phenylpiperidines as nociceptin receptor ligands: Part 2. DMWHMNY RU https://pubmed.ncbi.nlm.nih.gov/17420123 DMWHMNY DI DMWHMNY DMWHMNY DN 1-benzhydryl-4-(2-methoxyphenyl)piperidin-4-ol DMWHMNY MI TT27RFC DMWHMNY MN Opioid receptor delta (OPRD1) DMWHMNY MT DTT DMWHMNY MA Inhibitor DMWHMNY RN Bioorg Med Chem Lett. 2007 Jun 1;17(11):3028-33. Epub 2007 Mar 21.Synthesis and structure-activity relationships of 4-hydroxy-4-phenylpiperidines as nociceptin receptor ligands: Part 2. DMWHMNY RU https://pubmed.ncbi.nlm.nih.gov/17420123 DMWHMNY DI DMWHMNY DMWHMNY DN 1-benzhydryl-4-(2-methoxyphenyl)piperidin-4-ol DMWHMNY MI TTQW87Y DMWHMNY MN Opioid receptor kappa (OPRK1) DMWHMNY MT DTT DMWHMNY MA Inhibitor DMWHMNY RN Bioorg Med Chem Lett. 2007 Jun 1;17(11):3028-33. Epub 2007 Mar 21.Synthesis and structure-activity relationships of 4-hydroxy-4-phenylpiperidines as nociceptin receptor ligands: Part 2. DMWHMNY RU https://pubmed.ncbi.nlm.nih.gov/17420123 DMWHMNY DI DMWHMNY DMWHMNY DN 1-benzhydryl-4-(2-methoxyphenyl)piperidin-4-ol DMWHMNY MI TTKWM86 DMWHMNY MN Opioid receptor mu (MOP) DMWHMNY MT DTT DMWHMNY MA Inhibitor DMWHMNY RN Bioorg Med Chem Lett. 2007 Jun 1;17(11):3028-33. Epub 2007 Mar 21.Synthesis and structure-activity relationships of 4-hydroxy-4-phenylpiperidines as nociceptin receptor ligands: Part 2. DMWHMNY RU https://pubmed.ncbi.nlm.nih.gov/17420123 DMTYKMR DI DMTYKMR DMTYKMR DN 1-benzhydryl-4-(3,3-diphenylpropyl)piperazine DMTYKMR MI TTFK1JQ DMTYKMR MN Voltage-gated calcium channel alpha-2/delta-1 (CACNA2D1) DMTYKMR MT DTT DMTYKMR MA Inhibitor DMTYKMR RN Scaffold-based design and synthesis of potent N-type calcium channel blockers. Bioorg Med Chem Lett. 2009 Nov 15;19(22):6467-72. DMTYKMR RU https://pubmed.ncbi.nlm.nih.gov/19815411 DMXZFPB DI DMXZFPB DMXZFPB DN 1-benzhydryl-4-(3-fluorophenyl)piperidin-4-ol DMXZFPB MI TTNT7K8 DMXZFPB MN Nociceptin receptor (OPRL1) DMXZFPB MT DTT DMXZFPB MA Inhibitor DMXZFPB RN Bioorg Med Chem Lett. 2007 Jun 1;17(11):3028-33. Epub 2007 Mar 21.Synthesis and structure-activity relationships of 4-hydroxy-4-phenylpiperidines as nociceptin receptor ligands: Part 2. DMXZFPB RU https://pubmed.ncbi.nlm.nih.gov/17420123 DMXZFPB DI DMXZFPB DMXZFPB DN 1-benzhydryl-4-(3-fluorophenyl)piperidin-4-ol DMXZFPB MI TT27RFC DMXZFPB MN Opioid receptor delta (OPRD1) DMXZFPB MT DTT DMXZFPB MA Inhibitor DMXZFPB RN Bioorg Med Chem Lett. 2007 Jun 1;17(11):3028-33. Epub 2007 Mar 21.Synthesis and structure-activity relationships of 4-hydroxy-4-phenylpiperidines as nociceptin receptor ligands: Part 2. DMXZFPB RU https://pubmed.ncbi.nlm.nih.gov/17420123 DMXZFPB DI DMXZFPB DMXZFPB DN 1-benzhydryl-4-(3-fluorophenyl)piperidin-4-ol DMXZFPB MI TTQW87Y DMXZFPB MN Opioid receptor kappa (OPRK1) DMXZFPB MT DTT DMXZFPB MA Inhibitor DMXZFPB RN Bioorg Med Chem Lett. 2007 Jun 1;17(11):3028-33. Epub 2007 Mar 21.Synthesis and structure-activity relationships of 4-hydroxy-4-phenylpiperidines as nociceptin receptor ligands: Part 2. DMXZFPB RU https://pubmed.ncbi.nlm.nih.gov/17420123 DMXZFPB DI DMXZFPB DMXZFPB DN 1-benzhydryl-4-(3-fluorophenyl)piperidin-4-ol DMXZFPB MI TTKWM86 DMXZFPB MN Opioid receptor mu (MOP) DMXZFPB MT DTT DMXZFPB MA Inhibitor DMXZFPB RN Bioorg Med Chem Lett. 2007 Jun 1;17(11):3028-33. Epub 2007 Mar 21.Synthesis and structure-activity relationships of 4-hydroxy-4-phenylpiperidines as nociceptin receptor ligands: Part 2. DMXZFPB RU https://pubmed.ncbi.nlm.nih.gov/17420123 DM1QYS8 DI DM1QYS8 DM1QYS8 DN 1-benzhydryl-4-(3-methoxyphenyl)piperidin-4-ol DM1QYS8 MI TTNT7K8 DM1QYS8 MN Nociceptin receptor (OPRL1) DM1QYS8 MT DTT DM1QYS8 MA Inhibitor DM1QYS8 RN Bioorg Med Chem Lett. 2007 Jun 1;17(11):3028-33. Epub 2007 Mar 21.Synthesis and structure-activity relationships of 4-hydroxy-4-phenylpiperidines as nociceptin receptor ligands: Part 2. DM1QYS8 RU https://pubmed.ncbi.nlm.nih.gov/17420123 DM1QYS8 DI DM1QYS8 DM1QYS8 DN 1-benzhydryl-4-(3-methoxyphenyl)piperidin-4-ol DM1QYS8 MI TT27RFC DM1QYS8 MN Opioid receptor delta (OPRD1) DM1QYS8 MT DTT DM1QYS8 MA Inhibitor DM1QYS8 RN Bioorg Med Chem Lett. 2007 Jun 1;17(11):3028-33. Epub 2007 Mar 21.Synthesis and structure-activity relationships of 4-hydroxy-4-phenylpiperidines as nociceptin receptor ligands: Part 2. DM1QYS8 RU https://pubmed.ncbi.nlm.nih.gov/17420123 DM1QYS8 DI DM1QYS8 DM1QYS8 DN 1-benzhydryl-4-(3-methoxyphenyl)piperidin-4-ol DM1QYS8 MI TTQW87Y DM1QYS8 MN Opioid receptor kappa (OPRK1) DM1QYS8 MT DTT DM1QYS8 MA Inhibitor DM1QYS8 RN Bioorg Med Chem Lett. 2007 Jun 1;17(11):3028-33. Epub 2007 Mar 21.Synthesis and structure-activity relationships of 4-hydroxy-4-phenylpiperidines as nociceptin receptor ligands: Part 2. DM1QYS8 RU https://pubmed.ncbi.nlm.nih.gov/17420123 DM1QYS8 DI DM1QYS8 DM1QYS8 DN 1-benzhydryl-4-(3-methoxyphenyl)piperidin-4-ol DM1QYS8 MI TTKWM86 DM1QYS8 MN Opioid receptor mu (MOP) DM1QYS8 MT DTT DM1QYS8 MA Inhibitor DM1QYS8 RN Bioorg Med Chem Lett. 2007 Jun 1;17(11):3028-33. Epub 2007 Mar 21.Synthesis and structure-activity relationships of 4-hydroxy-4-phenylpiperidines as nociceptin receptor ligands: Part 2. DM1QYS8 RU https://pubmed.ncbi.nlm.nih.gov/17420123 DMIT7SH DI DMIT7SH DMIT7SH DN 1-benzhydryl-4-(3-phenylpropyl)piperidin-4-ol DMIT7SH MI TTNT7K8 DMIT7SH MN Nociceptin receptor (OPRL1) DMIT7SH MT DTT DMIT7SH MA Inhibitor DMIT7SH RN Bioorg Med Chem Lett. 2007 Jun 1;17(11):3028-33. Epub 2007 Mar 21.Synthesis and structure-activity relationships of 4-hydroxy-4-phenylpiperidines as nociceptin receptor ligands: Part 2. DMIT7SH RU https://pubmed.ncbi.nlm.nih.gov/17420123 DMIT7SH DI DMIT7SH DMIT7SH DN 1-benzhydryl-4-(3-phenylpropyl)piperidin-4-ol DMIT7SH MI TT27RFC DMIT7SH MN Opioid receptor delta (OPRD1) DMIT7SH MT DTT DMIT7SH MA Inhibitor DMIT7SH RN Bioorg Med Chem Lett. 2007 Jun 1;17(11):3028-33. Epub 2007 Mar 21.Synthesis and structure-activity relationships of 4-hydroxy-4-phenylpiperidines as nociceptin receptor ligands: Part 2. DMIT7SH RU https://pubmed.ncbi.nlm.nih.gov/17420123 DMIT7SH DI DMIT7SH DMIT7SH DN 1-benzhydryl-4-(3-phenylpropyl)piperidin-4-ol DMIT7SH MI TTQW87Y DMIT7SH MN Opioid receptor kappa (OPRK1) DMIT7SH MT DTT DMIT7SH MA Inhibitor DMIT7SH RN Bioorg Med Chem Lett. 2007 Jun 1;17(11):3028-33. Epub 2007 Mar 21.Synthesis and structure-activity relationships of 4-hydroxy-4-phenylpiperidines as nociceptin receptor ligands: Part 2. DMIT7SH RU https://pubmed.ncbi.nlm.nih.gov/17420123 DMIT7SH DI DMIT7SH DMIT7SH DN 1-benzhydryl-4-(3-phenylpropyl)piperidin-4-ol DMIT7SH MI TTKWM86 DMIT7SH MN Opioid receptor mu (MOP) DMIT7SH MT DTT DMIT7SH MA Inhibitor DMIT7SH RN Bioorg Med Chem Lett. 2007 Jun 1;17(11):3028-33. Epub 2007 Mar 21.Synthesis and structure-activity relationships of 4-hydroxy-4-phenylpiperidines as nociceptin receptor ligands: Part 2. DMIT7SH RU https://pubmed.ncbi.nlm.nih.gov/17420123 DM5SWL7 DI DM5SWL7 DM5SWL7 DN 1-benzhydryl-4-(4,4-diphenylbutyl)piperazine DM5SWL7 MI TTFK1JQ DM5SWL7 MN Voltage-gated calcium channel alpha-2/delta-1 (CACNA2D1) DM5SWL7 MT DTT DM5SWL7 MA Inhibitor DM5SWL7 RN Scaffold-based design and synthesis of potent N-type calcium channel blockers. Bioorg Med Chem Lett. 2009 Nov 15;19(22):6467-72. DM5SWL7 RU https://pubmed.ncbi.nlm.nih.gov/19815411 DM0BQYX DI DM0BQYX DM0BQYX DN 1-benzhydryl-4-(4-bromophenyl)piperidin-4-ol DM0BQYX MI TTNT7K8 DM0BQYX MN Nociceptin receptor (OPRL1) DM0BQYX MT DTT DM0BQYX MA Inhibitor DM0BQYX RN Bioorg Med Chem Lett. 2007 Jun 1;17(11):3028-33. Epub 2007 Mar 21.Synthesis and structure-activity relationships of 4-hydroxy-4-phenylpiperidines as nociceptin receptor ligands: Part 2. DM0BQYX RU https://pubmed.ncbi.nlm.nih.gov/17420123 DM0BQYX DI DM0BQYX DM0BQYX DN 1-benzhydryl-4-(4-bromophenyl)piperidin-4-ol DM0BQYX MI TT27RFC DM0BQYX MN Opioid receptor delta (OPRD1) DM0BQYX MT DTT DM0BQYX MA Inhibitor DM0BQYX RN Bioorg Med Chem Lett. 2007 Jun 1;17(11):3028-33. Epub 2007 Mar 21.Synthesis and structure-activity relationships of 4-hydroxy-4-phenylpiperidines as nociceptin receptor ligands: Part 2. DM0BQYX RU https://pubmed.ncbi.nlm.nih.gov/17420123 DM0BQYX DI DM0BQYX DM0BQYX DN 1-benzhydryl-4-(4-bromophenyl)piperidin-4-ol DM0BQYX MI TTQW87Y DM0BQYX MN Opioid receptor kappa (OPRK1) DM0BQYX MT DTT DM0BQYX MA Inhibitor DM0BQYX RN Bioorg Med Chem Lett. 2007 Jun 1;17(11):3028-33. Epub 2007 Mar 21.Synthesis and structure-activity relationships of 4-hydroxy-4-phenylpiperidines as nociceptin receptor ligands: Part 2. DM0BQYX RU https://pubmed.ncbi.nlm.nih.gov/17420123 DM0BQYX DI DM0BQYX DM0BQYX DN 1-benzhydryl-4-(4-bromophenyl)piperidin-4-ol DM0BQYX MI TTKWM86 DM0BQYX MN Opioid receptor mu (MOP) DM0BQYX MT DTT DM0BQYX MA Inhibitor DM0BQYX RN Bioorg Med Chem Lett. 2007 Jun 1;17(11):3028-33. Epub 2007 Mar 21.Synthesis and structure-activity relationships of 4-hydroxy-4-phenylpiperidines as nociceptin receptor ligands: Part 2. DM0BQYX RU https://pubmed.ncbi.nlm.nih.gov/17420123 DMMAJW9 DI DMMAJW9 DMMAJW9 DN 1-benzhydryl-4-(4-butylphenyl)piperidin-4-ol DMMAJW9 MI TTNT7K8 DMMAJW9 MN Nociceptin receptor (OPRL1) DMMAJW9 MT DTT DMMAJW9 MA Inhibitor DMMAJW9 RN Bioorg Med Chem Lett. 2007 Jun 1;17(11):3028-33. Epub 2007 Mar 21.Synthesis and structure-activity relationships of 4-hydroxy-4-phenylpiperidines as nociceptin receptor ligands: Part 2. DMMAJW9 RU https://pubmed.ncbi.nlm.nih.gov/17420123 DMWYG8K DI DMWYG8K DMWYG8K DN 1-benzhydryl-4-(4-chlorophenyl)piperidin-4-ol DMWYG8K MI TTNT7K8 DMWYG8K MN Nociceptin receptor (OPRL1) DMWYG8K MT DTT DMWYG8K MA Inhibitor DMWYG8K RN Bioorg Med Chem Lett. 2007 Jun 1;17(11):3028-33. Epub 2007 Mar 21.Synthesis and structure-activity relationships of 4-hydroxy-4-phenylpiperidines as nociceptin receptor ligands: Part 2. DMWYG8K RU https://pubmed.ncbi.nlm.nih.gov/17420123 DMWYG8K DI DMWYG8K DMWYG8K DN 1-benzhydryl-4-(4-chlorophenyl)piperidin-4-ol DMWYG8K MI TT27RFC DMWYG8K MN Opioid receptor delta (OPRD1) DMWYG8K MT DTT DMWYG8K MA Inhibitor DMWYG8K RN Bioorg Med Chem Lett. 2007 Jun 1;17(11):3028-33. Epub 2007 Mar 21.Synthesis and structure-activity relationships of 4-hydroxy-4-phenylpiperidines as nociceptin receptor ligands: Part 2. DMWYG8K RU https://pubmed.ncbi.nlm.nih.gov/17420123 DMWYG8K DI DMWYG8K DMWYG8K DN 1-benzhydryl-4-(4-chlorophenyl)piperidin-4-ol DMWYG8K MI TTQW87Y DMWYG8K MN Opioid receptor kappa (OPRK1) DMWYG8K MT DTT DMWYG8K MA Inhibitor DMWYG8K RN Bioorg Med Chem Lett. 2007 Jun 1;17(11):3028-33. Epub 2007 Mar 21.Synthesis and structure-activity relationships of 4-hydroxy-4-phenylpiperidines as nociceptin receptor ligands: Part 2. DMWYG8K RU https://pubmed.ncbi.nlm.nih.gov/17420123 DMWYG8K DI DMWYG8K DMWYG8K DN 1-benzhydryl-4-(4-chlorophenyl)piperidin-4-ol DMWYG8K MI TTKWM86 DMWYG8K MN Opioid receptor mu (MOP) DMWYG8K MT DTT DMWYG8K MA Inhibitor DMWYG8K RN Bioorg Med Chem Lett. 2007 Jun 1;17(11):3028-33. Epub 2007 Mar 21.Synthesis and structure-activity relationships of 4-hydroxy-4-phenylpiperidines as nociceptin receptor ligands: Part 2. DMWYG8K RU https://pubmed.ncbi.nlm.nih.gov/17420123 DME0BJD DI DME0BJD DME0BJD DN 1-benzhydryl-4-(4-ethylphenyl)piperidin-4-ol DME0BJD MI TTNT7K8 DME0BJD MN Nociceptin receptor (OPRL1) DME0BJD MT DTT DME0BJD MA Inhibitor DME0BJD RN Bioorg Med Chem Lett. 2007 Jun 1;17(11):3028-33. Epub 2007 Mar 21.Synthesis and structure-activity relationships of 4-hydroxy-4-phenylpiperidines as nociceptin receptor ligands: Part 2. DME0BJD RU https://pubmed.ncbi.nlm.nih.gov/17420123 DME0BJD DI DME0BJD DME0BJD DN 1-benzhydryl-4-(4-ethylphenyl)piperidin-4-ol DME0BJD MI TTQW87Y DME0BJD MN Opioid receptor kappa (OPRK1) DME0BJD MT DTT DME0BJD MA Inhibitor DME0BJD RN Bioorg Med Chem Lett. 2007 Jun 1;17(11):3028-33. Epub 2007 Mar 21.Synthesis and structure-activity relationships of 4-hydroxy-4-phenylpiperidines as nociceptin receptor ligands: Part 2. DME0BJD RU https://pubmed.ncbi.nlm.nih.gov/17420123 DME0BJD DI DME0BJD DME0BJD DN 1-benzhydryl-4-(4-ethylphenyl)piperidin-4-ol DME0BJD MI TTKWM86 DME0BJD MN Opioid receptor mu (MOP) DME0BJD MT DTT DME0BJD MA Inhibitor DME0BJD RN Bioorg Med Chem Lett. 2007 Jun 1;17(11):3028-33. Epub 2007 Mar 21.Synthesis and structure-activity relationships of 4-hydroxy-4-phenylpiperidines as nociceptin receptor ligands: Part 2. DME0BJD RU https://pubmed.ncbi.nlm.nih.gov/17420123 DMRNZD6 DI DMRNZD6 DMRNZD6 DN 1-benzhydryl-4-(4-fluorophenyl)piperidin-4-ol DMRNZD6 MI TTNT7K8 DMRNZD6 MN Nociceptin receptor (OPRL1) DMRNZD6 MT DTT DMRNZD6 MA Inhibitor DMRNZD6 RN Bioorg Med Chem Lett. 2007 Jun 1;17(11):3028-33. Epub 2007 Mar 21.Synthesis and structure-activity relationships of 4-hydroxy-4-phenylpiperidines as nociceptin receptor ligands: Part 2. DMRNZD6 RU https://pubmed.ncbi.nlm.nih.gov/17420123 DMRNZD6 DI DMRNZD6 DMRNZD6 DN 1-benzhydryl-4-(4-fluorophenyl)piperidin-4-ol DMRNZD6 MI TT27RFC DMRNZD6 MN Opioid receptor delta (OPRD1) DMRNZD6 MT DTT DMRNZD6 MA Inhibitor DMRNZD6 RN Bioorg Med Chem Lett. 2007 Jun 1;17(11):3028-33. Epub 2007 Mar 21.Synthesis and structure-activity relationships of 4-hydroxy-4-phenylpiperidines as nociceptin receptor ligands: Part 2. DMRNZD6 RU https://pubmed.ncbi.nlm.nih.gov/17420123 DMRNZD6 DI DMRNZD6 DMRNZD6 DN 1-benzhydryl-4-(4-fluorophenyl)piperidin-4-ol DMRNZD6 MI TTQW87Y DMRNZD6 MN Opioid receptor kappa (OPRK1) DMRNZD6 MT DTT DMRNZD6 MA Inhibitor DMRNZD6 RN Bioorg Med Chem Lett. 2007 Jun 1;17(11):3028-33. Epub 2007 Mar 21.Synthesis and structure-activity relationships of 4-hydroxy-4-phenylpiperidines as nociceptin receptor ligands: Part 2. DMRNZD6 RU https://pubmed.ncbi.nlm.nih.gov/17420123 DMRNZD6 DI DMRNZD6 DMRNZD6 DN 1-benzhydryl-4-(4-fluorophenyl)piperidin-4-ol DMRNZD6 MI TTKWM86 DMRNZD6 MN Opioid receptor mu (MOP) DMRNZD6 MT DTT DMRNZD6 MA Inhibitor DMRNZD6 RN Bioorg Med Chem Lett. 2007 Jun 1;17(11):3028-33. Epub 2007 Mar 21.Synthesis and structure-activity relationships of 4-hydroxy-4-phenylpiperidines as nociceptin receptor ligands: Part 2. DMRNZD6 RU https://pubmed.ncbi.nlm.nih.gov/17420123 DMXT894 DI DMXT894 DMXT894 DN 1-benzhydryl-4-(4-methoxyphenyl)piperidin-4-ol DMXT894 MI TTNT7K8 DMXT894 MN Nociceptin receptor (OPRL1) DMXT894 MT DTT DMXT894 MA Inhibitor DMXT894 RN Bioorg Med Chem Lett. 2007 Jun 1;17(11):3028-33. Epub 2007 Mar 21.Synthesis and structure-activity relationships of 4-hydroxy-4-phenylpiperidines as nociceptin receptor ligands: Part 2. DMXT894 RU https://pubmed.ncbi.nlm.nih.gov/17420123 DMXT894 DI DMXT894 DMXT894 DN 1-benzhydryl-4-(4-methoxyphenyl)piperidin-4-ol DMXT894 MI TT27RFC DMXT894 MN Opioid receptor delta (OPRD1) DMXT894 MT DTT DMXT894 MA Inhibitor DMXT894 RN Bioorg Med Chem Lett. 2007 Jun 1;17(11):3028-33. Epub 2007 Mar 21.Synthesis and structure-activity relationships of 4-hydroxy-4-phenylpiperidines as nociceptin receptor ligands: Part 2. DMXT894 RU https://pubmed.ncbi.nlm.nih.gov/17420123 DMXT894 DI DMXT894 DMXT894 DN 1-benzhydryl-4-(4-methoxyphenyl)piperidin-4-ol DMXT894 MI TTQW87Y DMXT894 MN Opioid receptor kappa (OPRK1) DMXT894 MT DTT DMXT894 MA Inhibitor DMXT894 RN Bioorg Med Chem Lett. 2007 Jun 1;17(11):3028-33. Epub 2007 Mar 21.Synthesis and structure-activity relationships of 4-hydroxy-4-phenylpiperidines as nociceptin receptor ligands: Part 2. DMXT894 RU https://pubmed.ncbi.nlm.nih.gov/17420123 DMXT894 DI DMXT894 DMXT894 DN 1-benzhydryl-4-(4-methoxyphenyl)piperidin-4-ol DMXT894 MI TTKWM86 DMXT894 MN Opioid receptor mu (MOP) DMXT894 MT DTT DMXT894 MA Inhibitor DMXT894 RN Bioorg Med Chem Lett. 2007 Jun 1;17(11):3028-33. Epub 2007 Mar 21.Synthesis and structure-activity relationships of 4-hydroxy-4-phenylpiperidines as nociceptin receptor ligands: Part 2. DMXT894 RU https://pubmed.ncbi.nlm.nih.gov/17420123 DMJDUM5 DI DMJDUM5 DMJDUM5 DN 1-benzhydryl-4-(4-propylphenyl)piperidin-4-ol DMJDUM5 MI TTNT7K8 DMJDUM5 MN Nociceptin receptor (OPRL1) DMJDUM5 MT DTT DMJDUM5 MA Inhibitor DMJDUM5 RN Bioorg Med Chem Lett. 2007 Jun 1;17(11):3028-33. Epub 2007 Mar 21.Synthesis and structure-activity relationships of 4-hydroxy-4-phenylpiperidines as nociceptin receptor ligands: Part 2. DMJDUM5 RU https://pubmed.ncbi.nlm.nih.gov/17420123 DMJDUM5 DI DMJDUM5 DMJDUM5 DN 1-benzhydryl-4-(4-propylphenyl)piperidin-4-ol DMJDUM5 MI TTQW87Y DMJDUM5 MN Opioid receptor kappa (OPRK1) DMJDUM5 MT DTT DMJDUM5 MA Inhibitor DMJDUM5 RN Bioorg Med Chem Lett. 2007 Jun 1;17(11):3028-33. Epub 2007 Mar 21.Synthesis and structure-activity relationships of 4-hydroxy-4-phenylpiperidines as nociceptin receptor ligands: Part 2. DMJDUM5 RU https://pubmed.ncbi.nlm.nih.gov/17420123 DMJDUM5 DI DMJDUM5 DMJDUM5 DN 1-benzhydryl-4-(4-propylphenyl)piperidin-4-ol DMJDUM5 MI TTKWM86 DMJDUM5 MN Opioid receptor mu (MOP) DMJDUM5 MT DTT DMJDUM5 MA Inhibitor DMJDUM5 RN Bioorg Med Chem Lett. 2007 Jun 1;17(11):3028-33. Epub 2007 Mar 21.Synthesis and structure-activity relationships of 4-hydroxy-4-phenylpiperidines as nociceptin receptor ligands: Part 2. DMJDUM5 RU https://pubmed.ncbi.nlm.nih.gov/17420123 DMDRUBL DI DMDRUBL DMDRUBL DN 1-benzhydryl-4-(benzyloxy)-4-phenylpiperidine DMDRUBL MI TTNT7K8 DMDRUBL MN Nociceptin receptor (OPRL1) DMDRUBL MT DTT DMDRUBL MA Inhibitor DMDRUBL RN Bioorg Med Chem Lett. 2007 Jun 1;17(11):3023-7. Epub 2007 Mar 23.Synthesis and structure-activity relationships of 4-hydroxy-4-phenylpiperidines as nociceptin receptor ligands: Part 1. DMDRUBL RU https://pubmed.ncbi.nlm.nih.gov/17428659 DMDRUBL DI DMDRUBL DMDRUBL DN 1-benzhydryl-4-(benzyloxy)-4-phenylpiperidine DMDRUBL MI TT27RFC DMDRUBL MN Opioid receptor delta (OPRD1) DMDRUBL MT DTT DMDRUBL MA Inhibitor DMDRUBL RN Bioorg Med Chem Lett. 2007 Jun 1;17(11):3023-7. Epub 2007 Mar 23.Synthesis and structure-activity relationships of 4-hydroxy-4-phenylpiperidines as nociceptin receptor ligands: Part 1. DMDRUBL RU https://pubmed.ncbi.nlm.nih.gov/17428659 DMDRUBL DI DMDRUBL DMDRUBL DN 1-benzhydryl-4-(benzyloxy)-4-phenylpiperidine DMDRUBL MI TTQW87Y DMDRUBL MN Opioid receptor kappa (OPRK1) DMDRUBL MT DTT DMDRUBL MA Inhibitor DMDRUBL RN Bioorg Med Chem Lett. 2007 Jun 1;17(11):3023-7. Epub 2007 Mar 23.Synthesis and structure-activity relationships of 4-hydroxy-4-phenylpiperidines as nociceptin receptor ligands: Part 1. DMDRUBL RU https://pubmed.ncbi.nlm.nih.gov/17428659 DMMB2GV DI DMMB2GV DMMB2GV DN 1-benzhydryl-4-(furan-2-yl)piperidin-4-ol DMMB2GV MI TTNT7K8 DMMB2GV MN Nociceptin receptor (OPRL1) DMMB2GV MT DTT DMMB2GV MA Inhibitor DMMB2GV RN Bioorg Med Chem Lett. 2007 Jun 1;17(11):3028-33. Epub 2007 Mar 21.Synthesis and structure-activity relationships of 4-hydroxy-4-phenylpiperidines as nociceptin receptor ligands: Part 2. DMMB2GV RU https://pubmed.ncbi.nlm.nih.gov/17420123 DMMB2GV DI DMMB2GV DMMB2GV DN 1-benzhydryl-4-(furan-2-yl)piperidin-4-ol DMMB2GV MI TT27RFC DMMB2GV MN Opioid receptor delta (OPRD1) DMMB2GV MT DTT DMMB2GV MA Inhibitor DMMB2GV RN Bioorg Med Chem Lett. 2007 Jun 1;17(11):3028-33. Epub 2007 Mar 21.Synthesis and structure-activity relationships of 4-hydroxy-4-phenylpiperidines as nociceptin receptor ligands: Part 2. DMMB2GV RU https://pubmed.ncbi.nlm.nih.gov/17420123 DMMB2GV DI DMMB2GV DMMB2GV DN 1-benzhydryl-4-(furan-2-yl)piperidin-4-ol DMMB2GV MI TTQW87Y DMMB2GV MN Opioid receptor kappa (OPRK1) DMMB2GV MT DTT DMMB2GV MA Inhibitor DMMB2GV RN Bioorg Med Chem Lett. 2007 Jun 1;17(11):3028-33. Epub 2007 Mar 21.Synthesis and structure-activity relationships of 4-hydroxy-4-phenylpiperidines as nociceptin receptor ligands: Part 2. DMMB2GV RU https://pubmed.ncbi.nlm.nih.gov/17420123 DMMB2GV DI DMMB2GV DMMB2GV DN 1-benzhydryl-4-(furan-2-yl)piperidin-4-ol DMMB2GV MI TTKWM86 DMMB2GV MN Opioid receptor mu (MOP) DMMB2GV MT DTT DMMB2GV MA Inhibitor DMMB2GV RN Bioorg Med Chem Lett. 2007 Jun 1;17(11):3028-33. Epub 2007 Mar 21.Synthesis and structure-activity relationships of 4-hydroxy-4-phenylpiperidines as nociceptin receptor ligands: Part 2. DMMB2GV RU https://pubmed.ncbi.nlm.nih.gov/17420123 DMJ8F60 DI DMJ8F60 DMJ8F60 DN 1-benzhydryl-4-(pyridin-2-yl)piperidin-4-ol DMJ8F60 MI TTNT7K8 DMJ8F60 MN Nociceptin receptor (OPRL1) DMJ8F60 MT DTT DMJ8F60 MA Inhibitor DMJ8F60 RN Bioorg Med Chem Lett. 2007 Jun 1;17(11):3028-33. Epub 2007 Mar 21.Synthesis and structure-activity relationships of 4-hydroxy-4-phenylpiperidines as nociceptin receptor ligands: Part 2. DMJ8F60 RU https://pubmed.ncbi.nlm.nih.gov/17420123 DMJ8F60 DI DMJ8F60 DMJ8F60 DN 1-benzhydryl-4-(pyridin-2-yl)piperidin-4-ol DMJ8F60 MI TTQW87Y DMJ8F60 MN Opioid receptor kappa (OPRK1) DMJ8F60 MT DTT DMJ8F60 MA Inhibitor DMJ8F60 RN Bioorg Med Chem Lett. 2007 Jun 1;17(11):3028-33. Epub 2007 Mar 21.Synthesis and structure-activity relationships of 4-hydroxy-4-phenylpiperidines as nociceptin receptor ligands: Part 2. DMJ8F60 RU https://pubmed.ncbi.nlm.nih.gov/17420123 DMJ8F60 DI DMJ8F60 DMJ8F60 DN 1-benzhydryl-4-(pyridin-2-yl)piperidin-4-ol DMJ8F60 MI TTKWM86 DMJ8F60 MN Opioid receptor mu (MOP) DMJ8F60 MT DTT DMJ8F60 MA Inhibitor DMJ8F60 RN Bioorg Med Chem Lett. 2007 Jun 1;17(11):3028-33. Epub 2007 Mar 21.Synthesis and structure-activity relationships of 4-hydroxy-4-phenylpiperidines as nociceptin receptor ligands: Part 2. DMJ8F60 RU https://pubmed.ncbi.nlm.nih.gov/17420123 DMNOZR2 DI DMNOZR2 DMNOZR2 DN 1-benzhydryl-4-(thiophen-2-yl)piperidin-4-ol DMNOZR2 MI TTNT7K8 DMNOZR2 MN Nociceptin receptor (OPRL1) DMNOZR2 MT DTT DMNOZR2 MA Inhibitor DMNOZR2 RN Bioorg Med Chem Lett. 2007 Jun 1;17(11):3028-33. Epub 2007 Mar 21.Synthesis and structure-activity relationships of 4-hydroxy-4-phenylpiperidines as nociceptin receptor ligands: Part 2. DMNOZR2 RU https://pubmed.ncbi.nlm.nih.gov/17420123 DMNOZR2 DI DMNOZR2 DMNOZR2 DN 1-benzhydryl-4-(thiophen-2-yl)piperidin-4-ol DMNOZR2 MI TT27RFC DMNOZR2 MN Opioid receptor delta (OPRD1) DMNOZR2 MT DTT DMNOZR2 MA Inhibitor DMNOZR2 RN Bioorg Med Chem Lett. 2007 Jun 1;17(11):3028-33. Epub 2007 Mar 21.Synthesis and structure-activity relationships of 4-hydroxy-4-phenylpiperidines as nociceptin receptor ligands: Part 2. DMNOZR2 RU https://pubmed.ncbi.nlm.nih.gov/17420123 DMNOZR2 DI DMNOZR2 DMNOZR2 DN 1-benzhydryl-4-(thiophen-2-yl)piperidin-4-ol DMNOZR2 MI TTQW87Y DMNOZR2 MN Opioid receptor kappa (OPRK1) DMNOZR2 MT DTT DMNOZR2 MA Inhibitor DMNOZR2 RN Bioorg Med Chem Lett. 2007 Jun 1;17(11):3028-33. Epub 2007 Mar 21.Synthesis and structure-activity relationships of 4-hydroxy-4-phenylpiperidines as nociceptin receptor ligands: Part 2. DMNOZR2 RU https://pubmed.ncbi.nlm.nih.gov/17420123 DMNOZR2 DI DMNOZR2 DMNOZR2 DN 1-benzhydryl-4-(thiophen-2-yl)piperidin-4-ol DMNOZR2 MI TTKWM86 DMNOZR2 MN Opioid receptor mu (MOP) DMNOZR2 MT DTT DMNOZR2 MA Inhibitor DMNOZR2 RN Bioorg Med Chem Lett. 2007 Jun 1;17(11):3028-33. Epub 2007 Mar 21.Synthesis and structure-activity relationships of 4-hydroxy-4-phenylpiperidines as nociceptin receptor ligands: Part 2. DMNOZR2 RU https://pubmed.ncbi.nlm.nih.gov/17420123 DMVBR36 DI DMVBR36 DMVBR36 DN 1-benzhydryl-4-benzylpiperidin-4-ol DMVBR36 MI TTNT7K8 DMVBR36 MN Nociceptin receptor (OPRL1) DMVBR36 MT DTT DMVBR36 MA Inhibitor DMVBR36 RN Bioorg Med Chem Lett. 2007 Jun 1;17(11):3028-33. Epub 2007 Mar 21.Synthesis and structure-activity relationships of 4-hydroxy-4-phenylpiperidines as nociceptin receptor ligands: Part 2. DMVBR36 RU https://pubmed.ncbi.nlm.nih.gov/17420123 DMVBR36 DI DMVBR36 DMVBR36 DN 1-benzhydryl-4-benzylpiperidin-4-ol DMVBR36 MI TT27RFC DMVBR36 MN Opioid receptor delta (OPRD1) DMVBR36 MT DTT DMVBR36 MA Inhibitor DMVBR36 RN Bioorg Med Chem Lett. 2007 Jun 1;17(11):3028-33. Epub 2007 Mar 21.Synthesis and structure-activity relationships of 4-hydroxy-4-phenylpiperidines as nociceptin receptor ligands: Part 2. DMVBR36 RU https://pubmed.ncbi.nlm.nih.gov/17420123 DMVBR36 DI DMVBR36 DMVBR36 DN 1-benzhydryl-4-benzylpiperidin-4-ol DMVBR36 MI TTQW87Y DMVBR36 MN Opioid receptor kappa (OPRK1) DMVBR36 MT DTT DMVBR36 MA Inhibitor DMVBR36 RN Bioorg Med Chem Lett. 2007 Jun 1;17(11):3028-33. Epub 2007 Mar 21.Synthesis and structure-activity relationships of 4-hydroxy-4-phenylpiperidines as nociceptin receptor ligands: Part 2. DMVBR36 RU https://pubmed.ncbi.nlm.nih.gov/17420123 DMVBR36 DI DMVBR36 DMVBR36 DN 1-benzhydryl-4-benzylpiperidin-4-ol DMVBR36 MI TTKWM86 DMVBR36 MN Opioid receptor mu (MOP) DMVBR36 MT DTT DMVBR36 MA Inhibitor DMVBR36 RN Bioorg Med Chem Lett. 2007 Jun 1;17(11):3028-33. Epub 2007 Mar 21.Synthesis and structure-activity relationships of 4-hydroxy-4-phenylpiperidines as nociceptin receptor ligands: Part 2. DMVBR36 RU https://pubmed.ncbi.nlm.nih.gov/17420123 DMRN7SC DI DMRN7SC DMRN7SC DN 1-benzhydryl-4-butylpiperidin-4-ol DMRN7SC MI TTNT7K8 DMRN7SC MN Nociceptin receptor (OPRL1) DMRN7SC MT DTT DMRN7SC MA Inhibitor DMRN7SC RN Bioorg Med Chem Lett. 2007 Jun 1;17(11):3028-33. Epub 2007 Mar 21.Synthesis and structure-activity relationships of 4-hydroxy-4-phenylpiperidines as nociceptin receptor ligands: Part 2. DMRN7SC RU https://pubmed.ncbi.nlm.nih.gov/17420123 DMRN7SC DI DMRN7SC DMRN7SC DN 1-benzhydryl-4-butylpiperidin-4-ol DMRN7SC MI TT27RFC DMRN7SC MN Opioid receptor delta (OPRD1) DMRN7SC MT DTT DMRN7SC MA Inhibitor DMRN7SC RN Bioorg Med Chem Lett. 2007 Jun 1;17(11):3028-33. Epub 2007 Mar 21.Synthesis and structure-activity relationships of 4-hydroxy-4-phenylpiperidines as nociceptin receptor ligands: Part 2. DMRN7SC RU https://pubmed.ncbi.nlm.nih.gov/17420123 DMRN7SC DI DMRN7SC DMRN7SC DN 1-benzhydryl-4-butylpiperidin-4-ol DMRN7SC MI TTQW87Y DMRN7SC MN Opioid receptor kappa (OPRK1) DMRN7SC MT DTT DMRN7SC MA Inhibitor DMRN7SC RN Bioorg Med Chem Lett. 2007 Jun 1;17(11):3028-33. Epub 2007 Mar 21.Synthesis and structure-activity relationships of 4-hydroxy-4-phenylpiperidines as nociceptin receptor ligands: Part 2. DMRN7SC RU https://pubmed.ncbi.nlm.nih.gov/17420123 DMRN7SC DI DMRN7SC DMRN7SC DN 1-benzhydryl-4-butylpiperidin-4-ol DMRN7SC MI TTKWM86 DMRN7SC MN Opioid receptor mu (MOP) DMRN7SC MT DTT DMRN7SC MA Inhibitor DMRN7SC RN Bioorg Med Chem Lett. 2007 Jun 1;17(11):3028-33. Epub 2007 Mar 21.Synthesis and structure-activity relationships of 4-hydroxy-4-phenylpiperidines as nociceptin receptor ligands: Part 2. DMRN7SC RU https://pubmed.ncbi.nlm.nih.gov/17420123 DMZVSYD DI DMZVSYD DMZVSYD DN 1-benzhydryl-4-cyclohexylpiperidin-4-ol DMZVSYD MI TTNT7K8 DMZVSYD MN Nociceptin receptor (OPRL1) DMZVSYD MT DTT DMZVSYD MA Inhibitor DMZVSYD RN Bioorg Med Chem Lett. 2007 Jun 1;17(11):3028-33. Epub 2007 Mar 21.Synthesis and structure-activity relationships of 4-hydroxy-4-phenylpiperidines as nociceptin receptor ligands: Part 2. DMZVSYD RU https://pubmed.ncbi.nlm.nih.gov/17420123 DMZVSYD DI DMZVSYD DMZVSYD DN 1-benzhydryl-4-cyclohexylpiperidin-4-ol DMZVSYD MI TT27RFC DMZVSYD MN Opioid receptor delta (OPRD1) DMZVSYD MT DTT DMZVSYD MA Inhibitor DMZVSYD RN Bioorg Med Chem Lett. 2007 Jun 1;17(11):3028-33. Epub 2007 Mar 21.Synthesis and structure-activity relationships of 4-hydroxy-4-phenylpiperidines as nociceptin receptor ligands: Part 2. DMZVSYD RU https://pubmed.ncbi.nlm.nih.gov/17420123 DMZVSYD DI DMZVSYD DMZVSYD DN 1-benzhydryl-4-cyclohexylpiperidin-4-ol DMZVSYD MI TTQW87Y DMZVSYD MN Opioid receptor kappa (OPRK1) DMZVSYD MT DTT DMZVSYD MA Inhibitor DMZVSYD RN Bioorg Med Chem Lett. 2007 Jun 1;17(11):3028-33. Epub 2007 Mar 21.Synthesis and structure-activity relationships of 4-hydroxy-4-phenylpiperidines as nociceptin receptor ligands: Part 2. DMZVSYD RU https://pubmed.ncbi.nlm.nih.gov/17420123 DMZVSYD DI DMZVSYD DMZVSYD DN 1-benzhydryl-4-cyclohexylpiperidin-4-ol DMZVSYD MI TTKWM86 DMZVSYD MN Opioid receptor mu (MOP) DMZVSYD MT DTT DMZVSYD MA Inhibitor DMZVSYD RN Bioorg Med Chem Lett. 2007 Jun 1;17(11):3028-33. Epub 2007 Mar 21.Synthesis and structure-activity relationships of 4-hydroxy-4-phenylpiperidines as nociceptin receptor ligands: Part 2. DMZVSYD RU https://pubmed.ncbi.nlm.nih.gov/17420123 DMM94Y2 DI DMM94Y2 DMM94Y2 DN 1-benzhydryl-4-cyclopropylpiperidin-4-ol DMM94Y2 MI TTNT7K8 DMM94Y2 MN Nociceptin receptor (OPRL1) DMM94Y2 MT DTT DMM94Y2 MA Inhibitor DMM94Y2 RN Bioorg Med Chem Lett. 2007 Jun 1;17(11):3028-33. Epub 2007 Mar 21.Synthesis and structure-activity relationships of 4-hydroxy-4-phenylpiperidines as nociceptin receptor ligands: Part 2. DMM94Y2 RU https://pubmed.ncbi.nlm.nih.gov/17420123 DMM94Y2 DI DMM94Y2 DMM94Y2 DN 1-benzhydryl-4-cyclopropylpiperidin-4-ol DMM94Y2 MI TTKWM86 DMM94Y2 MN Opioid receptor mu (MOP) DMM94Y2 MT DTT DMM94Y2 MA Inhibitor DMM94Y2 RN Bioorg Med Chem Lett. 2007 Jun 1;17(11):3028-33. Epub 2007 Mar 21.Synthesis and structure-activity relationships of 4-hydroxy-4-phenylpiperidines as nociceptin receptor ligands: Part 2. DMM94Y2 RU https://pubmed.ncbi.nlm.nih.gov/17420123 DM6PIL2 DI DM6PIL2 DM6PIL2 DN 1-benzhydryl-4-ethoxy-4-phenylpiperidine DM6PIL2 MI TTNT7K8 DM6PIL2 MN Nociceptin receptor (OPRL1) DM6PIL2 MT DTT DM6PIL2 MA Inhibitor DM6PIL2 RN Bioorg Med Chem Lett. 2007 Jun 1;17(11):3023-7. Epub 2007 Mar 23.Synthesis and structure-activity relationships of 4-hydroxy-4-phenylpiperidines as nociceptin receptor ligands: Part 1. DM6PIL2 RU https://pubmed.ncbi.nlm.nih.gov/17428659 DM6PIL2 DI DM6PIL2 DM6PIL2 DN 1-benzhydryl-4-ethoxy-4-phenylpiperidine DM6PIL2 MI TT27RFC DM6PIL2 MN Opioid receptor delta (OPRD1) DM6PIL2 MT DTT DM6PIL2 MA Inhibitor DM6PIL2 RN Bioorg Med Chem Lett. 2007 Jun 1;17(11):3023-7. Epub 2007 Mar 23.Synthesis and structure-activity relationships of 4-hydroxy-4-phenylpiperidines as nociceptin receptor ligands: Part 1. DM6PIL2 RU https://pubmed.ncbi.nlm.nih.gov/17428659 DM6PIL2 DI DM6PIL2 DM6PIL2 DN 1-benzhydryl-4-ethoxy-4-phenylpiperidine DM6PIL2 MI TTQW87Y DM6PIL2 MN Opioid receptor kappa (OPRK1) DM6PIL2 MT DTT DM6PIL2 MA Inhibitor DM6PIL2 RN Bioorg Med Chem Lett. 2007 Jun 1;17(11):3023-7. Epub 2007 Mar 23.Synthesis and structure-activity relationships of 4-hydroxy-4-phenylpiperidines as nociceptin receptor ligands: Part 1. DM6PIL2 RU https://pubmed.ncbi.nlm.nih.gov/17428659 DM6PIL2 DI DM6PIL2 DM6PIL2 DN 1-benzhydryl-4-ethoxy-4-phenylpiperidine DM6PIL2 MI TTKWM86 DM6PIL2 MN Opioid receptor mu (MOP) DM6PIL2 MT DTT DM6PIL2 MA Inhibitor DM6PIL2 RN Bioorg Med Chem Lett. 2007 Jun 1;17(11):3023-7. Epub 2007 Mar 23.Synthesis and structure-activity relationships of 4-hydroxy-4-phenylpiperidines as nociceptin receptor ligands: Part 1. DM6PIL2 RU https://pubmed.ncbi.nlm.nih.gov/17428659 DMUK95S DI DMUK95S DMUK95S DN 1-benzhydryl-4-hexylpiperidin-4-ol DMUK95S MI TTNT7K8 DMUK95S MN Nociceptin receptor (OPRL1) DMUK95S MT DTT DMUK95S MA Inhibitor DMUK95S RN Bioorg Med Chem Lett. 2007 Jun 1;17(11):3028-33. Epub 2007 Mar 21.Synthesis and structure-activity relationships of 4-hydroxy-4-phenylpiperidines as nociceptin receptor ligands: Part 2. DMUK95S RU https://pubmed.ncbi.nlm.nih.gov/17420123 DMUK95S DI DMUK95S DMUK95S DN 1-benzhydryl-4-hexylpiperidin-4-ol DMUK95S MI TT27RFC DMUK95S MN Opioid receptor delta (OPRD1) DMUK95S MT DTT DMUK95S MA Inhibitor DMUK95S RN Bioorg Med Chem Lett. 2007 Jun 1;17(11):3028-33. Epub 2007 Mar 21.Synthesis and structure-activity relationships of 4-hydroxy-4-phenylpiperidines as nociceptin receptor ligands: Part 2. DMUK95S RU https://pubmed.ncbi.nlm.nih.gov/17420123 DMUK95S DI DMUK95S DMUK95S DN 1-benzhydryl-4-hexylpiperidin-4-ol DMUK95S MI TTQW87Y DMUK95S MN Opioid receptor kappa (OPRK1) DMUK95S MT DTT DMUK95S MA Inhibitor DMUK95S RN Bioorg Med Chem Lett. 2007 Jun 1;17(11):3028-33. Epub 2007 Mar 21.Synthesis and structure-activity relationships of 4-hydroxy-4-phenylpiperidines as nociceptin receptor ligands: Part 2. DMUK95S RU https://pubmed.ncbi.nlm.nih.gov/17420123 DMUK95S DI DMUK95S DMUK95S DN 1-benzhydryl-4-hexylpiperidin-4-ol DMUK95S MI TTKWM86 DMUK95S MN Opioid receptor mu (MOP) DMUK95S MT DTT DMUK95S MA Inhibitor DMUK95S RN Bioorg Med Chem Lett. 2007 Jun 1;17(11):3028-33. Epub 2007 Mar 21.Synthesis and structure-activity relationships of 4-hydroxy-4-phenylpiperidines as nociceptin receptor ligands: Part 2. DMUK95S RU https://pubmed.ncbi.nlm.nih.gov/17420123 DMGYCQ3 DI DMGYCQ3 DMGYCQ3 DN 1-benzhydryl-4-isopropylpiperidin-4-ol DMGYCQ3 MI TTNT7K8 DMGYCQ3 MN Nociceptin receptor (OPRL1) DMGYCQ3 MT DTT DMGYCQ3 MA Inhibitor DMGYCQ3 RN Bioorg Med Chem Lett. 2007 Jun 1;17(11):3028-33. Epub 2007 Mar 21.Synthesis and structure-activity relationships of 4-hydroxy-4-phenylpiperidines as nociceptin receptor ligands: Part 2. DMGYCQ3 RU https://pubmed.ncbi.nlm.nih.gov/17420123 DMGYCQ3 DI DMGYCQ3 DMGYCQ3 DN 1-benzhydryl-4-isopropylpiperidin-4-ol DMGYCQ3 MI TTQW87Y DMGYCQ3 MN Opioid receptor kappa (OPRK1) DMGYCQ3 MT DTT DMGYCQ3 MA Inhibitor DMGYCQ3 RN Bioorg Med Chem Lett. 2007 Jun 1;17(11):3028-33. Epub 2007 Mar 21.Synthesis and structure-activity relationships of 4-hydroxy-4-phenylpiperidines as nociceptin receptor ligands: Part 2. DMGYCQ3 RU https://pubmed.ncbi.nlm.nih.gov/17420123 DMGYCQ3 DI DMGYCQ3 DMGYCQ3 DN 1-benzhydryl-4-isopropylpiperidin-4-ol DMGYCQ3 MI TTKWM86 DMGYCQ3 MN Opioid receptor mu (MOP) DMGYCQ3 MT DTT DMGYCQ3 MA Inhibitor DMGYCQ3 RN Bioorg Med Chem Lett. 2007 Jun 1;17(11):3028-33. Epub 2007 Mar 21.Synthesis and structure-activity relationships of 4-hydroxy-4-phenylpiperidines as nociceptin receptor ligands: Part 2. DMGYCQ3 RU https://pubmed.ncbi.nlm.nih.gov/17420123 DMBG0N8 DI DMBG0N8 DMBG0N8 DN 1-benzhydryl-4-methoxy-4-phenylpiperidine DMBG0N8 MI TTNT7K8 DMBG0N8 MN Nociceptin receptor (OPRL1) DMBG0N8 MT DTT DMBG0N8 MA Inhibitor DMBG0N8 RN Bioorg Med Chem Lett. 2007 Jun 1;17(11):3023-7. Epub 2007 Mar 23.Synthesis and structure-activity relationships of 4-hydroxy-4-phenylpiperidines as nociceptin receptor ligands: Part 1. DMBG0N8 RU https://pubmed.ncbi.nlm.nih.gov/17428659 DMBG0N8 DI DMBG0N8 DMBG0N8 DN 1-benzhydryl-4-methoxy-4-phenylpiperidine DMBG0N8 MI TT27RFC DMBG0N8 MN Opioid receptor delta (OPRD1) DMBG0N8 MT DTT DMBG0N8 MA Inhibitor DMBG0N8 RN Bioorg Med Chem Lett. 2007 Jun 1;17(11):3023-7. Epub 2007 Mar 23.Synthesis and structure-activity relationships of 4-hydroxy-4-phenylpiperidines as nociceptin receptor ligands: Part 1. DMBG0N8 RU https://pubmed.ncbi.nlm.nih.gov/17428659 DMBG0N8 DI DMBG0N8 DMBG0N8 DN 1-benzhydryl-4-methoxy-4-phenylpiperidine DMBG0N8 MI TTQW87Y DMBG0N8 MN Opioid receptor kappa (OPRK1) DMBG0N8 MT DTT DMBG0N8 MA Inhibitor DMBG0N8 RN Bioorg Med Chem Lett. 2007 Jun 1;17(11):3023-7. Epub 2007 Mar 23.Synthesis and structure-activity relationships of 4-hydroxy-4-phenylpiperidines as nociceptin receptor ligands: Part 1. DMBG0N8 RU https://pubmed.ncbi.nlm.nih.gov/17428659 DMBG0N8 DI DMBG0N8 DMBG0N8 DN 1-benzhydryl-4-methoxy-4-phenylpiperidine DMBG0N8 MI TTKWM86 DMBG0N8 MN Opioid receptor mu (MOP) DMBG0N8 MT DTT DMBG0N8 MA Inhibitor DMBG0N8 RN Bioorg Med Chem Lett. 2007 Jun 1;17(11):3023-7. Epub 2007 Mar 23.Synthesis and structure-activity relationships of 4-hydroxy-4-phenylpiperidines as nociceptin receptor ligands: Part 1. DMBG0N8 RU https://pubmed.ncbi.nlm.nih.gov/17428659 DMVJH1S DI DMVJH1S DMVJH1S DN 1-benzhydryl-4-m-tolylpiperidin-4-ol DMVJH1S MI TTNT7K8 DMVJH1S MN Nociceptin receptor (OPRL1) DMVJH1S MT DTT DMVJH1S MA Inhibitor DMVJH1S RN Bioorg Med Chem Lett. 2007 Jun 1;17(11):3028-33. Epub 2007 Mar 21.Synthesis and structure-activity relationships of 4-hydroxy-4-phenylpiperidines as nociceptin receptor ligands: Part 2. DMVJH1S RU https://pubmed.ncbi.nlm.nih.gov/17420123 DMVJH1S DI DMVJH1S DMVJH1S DN 1-benzhydryl-4-m-tolylpiperidin-4-ol DMVJH1S MI TT27RFC DMVJH1S MN Opioid receptor delta (OPRD1) DMVJH1S MT DTT DMVJH1S MA Inhibitor DMVJH1S RN Bioorg Med Chem Lett. 2007 Jun 1;17(11):3028-33. Epub 2007 Mar 21.Synthesis and structure-activity relationships of 4-hydroxy-4-phenylpiperidines as nociceptin receptor ligands: Part 2. DMVJH1S RU https://pubmed.ncbi.nlm.nih.gov/17420123 DMVJH1S DI DMVJH1S DMVJH1S DN 1-benzhydryl-4-m-tolylpiperidin-4-ol DMVJH1S MI TTQW87Y DMVJH1S MN Opioid receptor kappa (OPRK1) DMVJH1S MT DTT DMVJH1S MA Inhibitor DMVJH1S RN Bioorg Med Chem Lett. 2007 Jun 1;17(11):3028-33. Epub 2007 Mar 21.Synthesis and structure-activity relationships of 4-hydroxy-4-phenylpiperidines as nociceptin receptor ligands: Part 2. DMVJH1S RU https://pubmed.ncbi.nlm.nih.gov/17420123 DMVJH1S DI DMVJH1S DMVJH1S DN 1-benzhydryl-4-m-tolylpiperidin-4-ol DMVJH1S MI TTKWM86 DMVJH1S MN Opioid receptor mu (MOP) DMVJH1S MT DTT DMVJH1S MA Inhibitor DMVJH1S RN Bioorg Med Chem Lett. 2007 Jun 1;17(11):3028-33. Epub 2007 Mar 21.Synthesis and structure-activity relationships of 4-hydroxy-4-phenylpiperidines as nociceptin receptor ligands: Part 2. DMVJH1S RU https://pubmed.ncbi.nlm.nih.gov/17420123 DMVUMSF DI DMVUMSF DMVUMSF DN 1-benzhydryl-4-o-tolylpiperidin-4-ol DMVUMSF MI TTNT7K8 DMVUMSF MN Nociceptin receptor (OPRL1) DMVUMSF MT DTT DMVUMSF MA Inhibitor DMVUMSF RN Bioorg Med Chem Lett. 2007 Jun 1;17(11):3028-33. Epub 2007 Mar 21.Synthesis and structure-activity relationships of 4-hydroxy-4-phenylpiperidines as nociceptin receptor ligands: Part 2. DMVUMSF RU https://pubmed.ncbi.nlm.nih.gov/17420123 DMVUMSF DI DMVUMSF DMVUMSF DN 1-benzhydryl-4-o-tolylpiperidin-4-ol DMVUMSF MI TT27RFC DMVUMSF MN Opioid receptor delta (OPRD1) DMVUMSF MT DTT DMVUMSF MA Inhibitor DMVUMSF RN Bioorg Med Chem Lett. 2007 Jun 1;17(11):3028-33. Epub 2007 Mar 21.Synthesis and structure-activity relationships of 4-hydroxy-4-phenylpiperidines as nociceptin receptor ligands: Part 2. DMVUMSF RU https://pubmed.ncbi.nlm.nih.gov/17420123 DMVUMSF DI DMVUMSF DMVUMSF DN 1-benzhydryl-4-o-tolylpiperidin-4-ol DMVUMSF MI TTQW87Y DMVUMSF MN Opioid receptor kappa (OPRK1) DMVUMSF MT DTT DMVUMSF MA Inhibitor DMVUMSF RN Bioorg Med Chem Lett. 2007 Jun 1;17(11):3028-33. Epub 2007 Mar 21.Synthesis and structure-activity relationships of 4-hydroxy-4-phenylpiperidines as nociceptin receptor ligands: Part 2. DMVUMSF RU https://pubmed.ncbi.nlm.nih.gov/17420123 DMVUMSF DI DMVUMSF DMVUMSF DN 1-benzhydryl-4-o-tolylpiperidin-4-ol DMVUMSF MI TTKWM86 DMVUMSF MN Opioid receptor mu (MOP) DMVUMSF MT DTT DMVUMSF MA Inhibitor DMVUMSF RN Bioorg Med Chem Lett. 2007 Jun 1;17(11):3028-33. Epub 2007 Mar 21.Synthesis and structure-activity relationships of 4-hydroxy-4-phenylpiperidines as nociceptin receptor ligands: Part 2. DMVUMSF RU https://pubmed.ncbi.nlm.nih.gov/17420123 DMEB968 DI DMEB968 DMEB968 DN 1-benzhydryl-4-phenyl-4-propoxypiperidine DMEB968 MI TTNT7K8 DMEB968 MN Nociceptin receptor (OPRL1) DMEB968 MT DTT DMEB968 MA Inhibitor DMEB968 RN Bioorg Med Chem Lett. 2007 Jun 1;17(11):3023-7. Epub 2007 Mar 23.Synthesis and structure-activity relationships of 4-hydroxy-4-phenylpiperidines as nociceptin receptor ligands: Part 1. DMEB968 RU https://pubmed.ncbi.nlm.nih.gov/17428659 DMEB968 DI DMEB968 DMEB968 DN 1-benzhydryl-4-phenyl-4-propoxypiperidine DMEB968 MI TT27RFC DMEB968 MN Opioid receptor delta (OPRD1) DMEB968 MT DTT DMEB968 MA Inhibitor DMEB968 RN Bioorg Med Chem Lett. 2007 Jun 1;17(11):3023-7. Epub 2007 Mar 23.Synthesis and structure-activity relationships of 4-hydroxy-4-phenylpiperidines as nociceptin receptor ligands: Part 1. DMEB968 RU https://pubmed.ncbi.nlm.nih.gov/17428659 DMEB968 DI DMEB968 DMEB968 DN 1-benzhydryl-4-phenyl-4-propoxypiperidine DMEB968 MI TTQW87Y DMEB968 MN Opioid receptor kappa (OPRK1) DMEB968 MT DTT DMEB968 MA Inhibitor DMEB968 RN Bioorg Med Chem Lett. 2007 Jun 1;17(11):3023-7. Epub 2007 Mar 23.Synthesis and structure-activity relationships of 4-hydroxy-4-phenylpiperidines as nociceptin receptor ligands: Part 1. DMEB968 RU https://pubmed.ncbi.nlm.nih.gov/17428659 DMEB968 DI DMEB968 DMEB968 DN 1-benzhydryl-4-phenyl-4-propoxypiperidine DMEB968 MI TTKWM86 DMEB968 MN Opioid receptor mu (MOP) DMEB968 MT DTT DMEB968 MA Inhibitor DMEB968 RN Bioorg Med Chem Lett. 2007 Jun 1;17(11):3023-7. Epub 2007 Mar 23.Synthesis and structure-activity relationships of 4-hydroxy-4-phenylpiperidines as nociceptin receptor ligands: Part 1. DMEB968 RU https://pubmed.ncbi.nlm.nih.gov/17428659 DM7KU1X DI DM7KU1X DM7KU1X DN 1-benzhydryl-4-phenylpiperidin-4-ol DM7KU1X MI TTNT7K8 DM7KU1X MN Nociceptin receptor (OPRL1) DM7KU1X MT DTT DM7KU1X MA Inhibitor DM7KU1X RN The discovery of tropane derivatives as nociceptin receptor ligands for the management of cough and anxiety. Bioorg Med Chem Lett. 2009 May 1;19(9):2519-23. DM7KU1X RU https://pubmed.ncbi.nlm.nih.gov/19339177 DM7KU1X DI DM7KU1X DM7KU1X DN 1-benzhydryl-4-phenylpiperidin-4-ol DM7KU1X MI TT27RFC DM7KU1X MN Opioid receptor delta (OPRD1) DM7KU1X MT DTT DM7KU1X MA Inhibitor DM7KU1X RN The discovery of tropane derivatives as nociceptin receptor ligands for the management of cough and anxiety. Bioorg Med Chem Lett. 2009 May 1;19(9):2519-23. DM7KU1X RU https://pubmed.ncbi.nlm.nih.gov/19339177 DM7KU1X DI DM7KU1X DM7KU1X DN 1-benzhydryl-4-phenylpiperidin-4-ol DM7KU1X MI TTQW87Y DM7KU1X MN Opioid receptor kappa (OPRK1) DM7KU1X MT DTT DM7KU1X MA Inhibitor DM7KU1X RN The discovery of tropane derivatives as nociceptin receptor ligands for the management of cough and anxiety. Bioorg Med Chem Lett. 2009 May 1;19(9):2519-23. DM7KU1X RU https://pubmed.ncbi.nlm.nih.gov/19339177 DM7KU1X DI DM7KU1X DM7KU1X DN 1-benzhydryl-4-phenylpiperidin-4-ol DM7KU1X MI TTKWM86 DM7KU1X MN Opioid receptor mu (MOP) DM7KU1X MT DTT DM7KU1X MA Inhibitor DM7KU1X RN The discovery of tropane derivatives as nociceptin receptor ligands for the management of cough and anxiety. Bioorg Med Chem Lett. 2009 May 1;19(9):2519-23. DM7KU1X RU https://pubmed.ncbi.nlm.nih.gov/19339177 DM679RC DI DM679RC DM679RC DN 1-benzhydryl-4-p-tolylpiperidin-4-ol DM679RC MI TTNT7K8 DM679RC MN Nociceptin receptor (OPRL1) DM679RC MT DTT DM679RC MA Inhibitor DM679RC RN Bioorg Med Chem Lett. 2007 Jun 1;17(11):3028-33. Epub 2007 Mar 21.Synthesis and structure-activity relationships of 4-hydroxy-4-phenylpiperidines as nociceptin receptor ligands: Part 2. DM679RC RU https://pubmed.ncbi.nlm.nih.gov/17420123 DM679RC DI DM679RC DM679RC DN 1-benzhydryl-4-p-tolylpiperidin-4-ol DM679RC MI TT27RFC DM679RC MN Opioid receptor delta (OPRD1) DM679RC MT DTT DM679RC MA Inhibitor DM679RC RN Bioorg Med Chem Lett. 2007 Jun 1;17(11):3028-33. Epub 2007 Mar 21.Synthesis and structure-activity relationships of 4-hydroxy-4-phenylpiperidines as nociceptin receptor ligands: Part 2. DM679RC RU https://pubmed.ncbi.nlm.nih.gov/17420123 DM679RC DI DM679RC DM679RC DN 1-benzhydryl-4-p-tolylpiperidin-4-ol DM679RC MI TTQW87Y DM679RC MN Opioid receptor kappa (OPRK1) DM679RC MT DTT DM679RC MA Inhibitor DM679RC RN Bioorg Med Chem Lett. 2007 Jun 1;17(11):3028-33. Epub 2007 Mar 21.Synthesis and structure-activity relationships of 4-hydroxy-4-phenylpiperidines as nociceptin receptor ligands: Part 2. DM679RC RU https://pubmed.ncbi.nlm.nih.gov/17420123 DM679RC DI DM679RC DM679RC DN 1-benzhydryl-4-p-tolylpiperidin-4-ol DM679RC MI TTKWM86 DM679RC MN Opioid receptor mu (MOP) DM679RC MT DTT DM679RC MA Inhibitor DM679RC RN Bioorg Med Chem Lett. 2007 Jun 1;17(11):3028-33. Epub 2007 Mar 21.Synthesis and structure-activity relationships of 4-hydroxy-4-phenylpiperidines as nociceptin receptor ligands: Part 2. DM679RC RU https://pubmed.ncbi.nlm.nih.gov/17420123 DMM5DTF DI DMM5DTF DMM5DTF DN 1-benzhydryl-4-tert-butylpiperidin-4-ol DMM5DTF MI TTNT7K8 DMM5DTF MN Nociceptin receptor (OPRL1) DMM5DTF MT DTT DMM5DTF MA Inhibitor DMM5DTF RN Bioorg Med Chem Lett. 2007 Jun 1;17(11):3028-33. Epub 2007 Mar 21.Synthesis and structure-activity relationships of 4-hydroxy-4-phenylpiperidines as nociceptin receptor ligands: Part 2. DMM5DTF RU https://pubmed.ncbi.nlm.nih.gov/17420123 DMM5DTF DI DMM5DTF DMM5DTF DN 1-benzhydryl-4-tert-butylpiperidin-4-ol DMM5DTF MI TTQW87Y DMM5DTF MN Opioid receptor kappa (OPRK1) DMM5DTF MT DTT DMM5DTF MA Inhibitor DMM5DTF RN Bioorg Med Chem Lett. 2007 Jun 1;17(11):3028-33. Epub 2007 Mar 21.Synthesis and structure-activity relationships of 4-hydroxy-4-phenylpiperidines as nociceptin receptor ligands: Part 2. DMM5DTF RU https://pubmed.ncbi.nlm.nih.gov/17420123 DMM5DTF DI DMM5DTF DMM5DTF DN 1-benzhydryl-4-tert-butylpiperidin-4-ol DMM5DTF MI TTKWM86 DMM5DTF MN Opioid receptor mu (MOP) DMM5DTF MT DTT DMM5DTF MA Inhibitor DMM5DTF RN Bioorg Med Chem Lett. 2007 Jun 1;17(11):3028-33. Epub 2007 Mar 21.Synthesis and structure-activity relationships of 4-hydroxy-4-phenylpiperidines as nociceptin receptor ligands: Part 2. DMM5DTF RU https://pubmed.ncbi.nlm.nih.gov/17420123 DMMN5TA DI DMMN5TA DMMN5TA DN 1-Benzo[b]thiophen-2-yl-cycloheptylamine DMMN5TA MI TTVBI8W DMMN5TA MN Dopamine transporter (DAT) DMMN5TA MT DTT DMMN5TA MA Inhibitor DMMN5TA RN Synthesis and biological evaluation of 1-[1-(2-benzo[b]thienyl)cyclohexyl]piperidine homologues at dopamine-uptake and phencyclidine- and sigma-bin... J Med Chem. 1993 Apr 30;36(9):1188-93. DMMN5TA RU https://pubmed.ncbi.nlm.nih.gov/8098066 DMR97FU DI DMR97FU DMR97FU DN 1-Benzo[b]thiophen-2-yl-cyclohexylamine DMR97FU MI TTVBI8W DMR97FU MN Dopamine transporter (DAT) DMR97FU MT DTT DMR97FU MA Inhibitor DMR97FU RN Synthesis and biological evaluation of 1-[1-(2-benzo[b]thienyl)cyclohexyl]piperidine homologues at dopamine-uptake and phencyclidine- and sigma-bin... J Med Chem. 1993 Apr 30;36(9):1188-93. DMR97FU RU https://pubmed.ncbi.nlm.nih.gov/8098066 DM6EF1L DI DM6EF1L DM6EF1L DN 1-Benzo[b]thiophen-2-yl-cyclopentylamine DM6EF1L MI TTVBI8W DM6EF1L MN Dopamine transporter (DAT) DM6EF1L MT DTT DM6EF1L MA Inhibitor DM6EF1L RN Synthesis and biological evaluation of 1-[1-(2-benzo[b]thienyl)cyclohexyl]piperidine homologues at dopamine-uptake and phencyclidine- and sigma-bin... J Med Chem. 1993 Apr 30;36(9):1188-93. DM6EF1L RU https://pubmed.ncbi.nlm.nih.gov/8098066 DM153Y8 DI DM153Y8 DM153Y8 DN 1-Benzooxazol-2-yl-6-phenyl-hexan-1-one DM153Y8 MI TTDP1UC DM153Y8 MN Fatty acid amide hydrolase (FAAH) DM153Y8 MT DTT DM153Y8 MA Inhibitor DM153Y8 RN Discovery of a potent, selective, and efficacious class of reversible alpha-ketoheterocycle inhibitors of fatty acid amide hydrolase effective as a... J Med Chem. 2005 Mar 24;48(6):1849-56. DM153Y8 RU https://pubmed.ncbi.nlm.nih.gov/15771430 DMEZPC8 DI DMEZPC8 DMEZPC8 DN 1-Benzothiazol-2-yl-3-phenethyl-thiourea DMEZPC8 MI TT84ETX DMEZPC8 MN Human immunodeficiency virus Reverse transcriptase (HIV RT) DMEZPC8 MT DTT DMEZPC8 MA Inhibitor DMEZPC8 RN Phenethylthiazolethiourea (PETT) compounds, a new class of HIV-1 reverse transcriptase inhibitors. 1. Synthesis and basic structure-activity relati... J Med Chem. 1995 Dec 8;38(25):4929-36. DMEZPC8 RU https://pubmed.ncbi.nlm.nih.gov/8523406 DMF9X2T DI DMF9X2T DMF9X2T DN 1-benzoyl-2-benzyl-1,2-dihydropyridin-3(6H)-one DMF9X2T MI TT9W8GU DMF9X2T MN Gamma-secretase (GS) DMF9X2T MT DTT DMF9X2T MA Inhibitor DMF9X2T RN Novel gamma-secretase inhibitors discovered by library screening of in-house synthetic natural product intermediates. Bioorg Med Chem Lett. 2006 Jul 15;16(14):3813-6. DMF9X2T RU https://pubmed.ncbi.nlm.nih.gov/16682195 DMF9X2T DI DMF9X2T DMF9X2T DN 1-benzoyl-2-benzyl-1,2-dihydropyridin-3(6H)-one DMF9X2T MI TTZ3S8C DMF9X2T MN Presenilin 1 (PSEN1) DMF9X2T MT DTT DMF9X2T MA Inhibitor DMF9X2T RN Novel gamma-secretase inhibitors discovered by library screening of in-house synthetic natural product intermediates. Bioorg Med Chem Lett. 2006 Jul 15;16(14):3813-6. DMF9X2T RU https://pubmed.ncbi.nlm.nih.gov/16682195 DMF9X2T DI DMF9X2T DMF9X2T DN 1-benzoyl-2-benzyl-1,2-dihydropyridin-3(6H)-one DMF9X2T MI TTWN3F4 DMF9X2T MN Presenilin 2 (PSEN2) DMF9X2T MT DTT DMF9X2T MA Inhibitor DMF9X2T RN Novel gamma-secretase inhibitors discovered by library screening of in-house synthetic natural product intermediates. Bioorg Med Chem Lett. 2006 Jul 15;16(14):3813-6. DMF9X2T RU https://pubmed.ncbi.nlm.nih.gov/16682195 DMG5MNZ DI DMG5MNZ DMG5MNZ DN 1-benzoyl-N-phenyl-1H-pyrazole-3-carboxamide DMG5MNZ MI TT6L509 DMG5MNZ MN Coagulation factor IIa (F2) DMG5MNZ MT DTT DMG5MNZ MA Inhibitor DMG5MNZ RN N-benzoylpyrazoles are novel small-molecule inhibitors of human neutrophil elastase. J Med Chem. 2007 Oct 4;50(20):4928-38. DMG5MNZ RU https://pubmed.ncbi.nlm.nih.gov/17850059 DMG5MNZ DI DMG5MNZ DMG5MNZ DN 1-benzoyl-N-phenyl-1H-pyrazole-3-carboxamide DMG5MNZ MI TTPLTSQ DMG5MNZ MN Neutrophil elastase (NE) DMG5MNZ MT DTT DMG5MNZ MA Inhibitor DMG5MNZ RN N-benzoylpyrazoles are novel small-molecule inhibitors of human neutrophil elastase. J Med Chem. 2007 Oct 4;50(20):4928-38. DMG5MNZ RU https://pubmed.ncbi.nlm.nih.gov/17850059 DMG5MNZ DI DMG5MNZ DMG5MNZ DN 1-benzoyl-N-phenyl-1H-pyrazole-3-carboxamide DMG5MNZ MI TTMF8H9 DMG5MNZ MN Plasma kallikrein (KLKB1) DMG5MNZ MT DTT DMG5MNZ MA Inhibitor DMG5MNZ RN N-benzoylpyrazoles are novel small-molecule inhibitors of human neutrophil elastase. J Med Chem. 2007 Oct 4;50(20):4928-38. DMG5MNZ RU https://pubmed.ncbi.nlm.nih.gov/17850059 DMG5MNZ DI DMG5MNZ DMG5MNZ DN 1-benzoyl-N-phenyl-1H-pyrazole-3-carboxamide DMG5MNZ MI TTGY7WI DMG5MNZ MN Urokinase-type plasminogen activator (PLAU) DMG5MNZ MT DTT DMG5MNZ MA Inhibitor DMG5MNZ RN N-benzoylpyrazoles are novel small-molecule inhibitors of human neutrophil elastase. J Med Chem. 2007 Oct 4;50(20):4928-38. DMG5MNZ RU https://pubmed.ncbi.nlm.nih.gov/17850059 DM17TIX DI DM17TIX DM17TIX DN 1-Benzyl-1,2-dihydro-indazol-3-one DM17TIX MI TT2J34L DM17TIX MN Arachidonate 5-lipoxygenase (5-LOX) DM17TIX MT DTT DM17TIX MA Inhibitor DM17TIX RN Indazolinones, a new series of redox-active 5-lipoxygenase inhibitors with built-in selectivity and oral activity. J Med Chem. 1991 Mar;34(3):1028-36. DM17TIX RU https://pubmed.ncbi.nlm.nih.gov/1848292 DMUXSH5 DI DMUXSH5 DMUXSH5 DN 1-Benzyl-1,4-dihydro-4-oxo-3-pyridinesulfonamide DMUXSH5 MI TTHQPL7 DMUXSH5 MN Carbonic anhydrase I (CA-I) DMUXSH5 MT DTT DMUXSH5 MA Inhibitor DMUXSH5 RN Carbonic anhydrase inhibitors. Regioselective synthesis of novel 1-substituted 1,4-dihydro-4-oxo-3-pyridinesulfonamides and their inhibition of the... Eur J Med Chem. 2010 Sep;45(9):3656-61. DMUXSH5 RU https://pubmed.ncbi.nlm.nih.gov/20554082 DMUXSH5 DI DMUXSH5 DMUXSH5 DN 1-Benzyl-1,4-dihydro-4-oxo-3-pyridinesulfonamide DMUXSH5 MI TTANPDJ DMUXSH5 MN Carbonic anhydrase II (CA-II) DMUXSH5 MT DTT DMUXSH5 MA Inhibitor DMUXSH5 RN Carbonic anhydrase inhibitors. Regioselective synthesis of novel 1-substituted 1,4-dihydro-4-oxo-3-pyridinesulfonamides and their inhibition of the... Eur J Med Chem. 2010 Sep;45(9):3656-61. DMUXSH5 RU https://pubmed.ncbi.nlm.nih.gov/20554082 DMUXSH5 DI DMUXSH5 DMUXSH5 DN 1-Benzyl-1,4-dihydro-4-oxo-3-pyridinesulfonamide DMUXSH5 MI TT2LVK8 DMUXSH5 MN Carbonic anhydrase IX (CA-IX) DMUXSH5 MT DTT DMUXSH5 MA Inhibitor DMUXSH5 RN Carbonic anhydrase inhibitors. Regioselective synthesis of novel 1-substituted 1,4-dihydro-4-oxo-3-pyridinesulfonamides and their inhibition of the... Eur J Med Chem. 2010 Sep;45(9):3656-61. DMUXSH5 RU https://pubmed.ncbi.nlm.nih.gov/20554082 DMUXSH5 DI DMUXSH5 DMUXSH5 DN 1-Benzyl-1,4-dihydro-4-oxo-3-pyridinesulfonamide DMUXSH5 MI TTSYM0R DMUXSH5 MN Carbonic anhydrase XII (CA-XII) DMUXSH5 MT DTT DMUXSH5 MA Inhibitor DMUXSH5 RN Carbonic anhydrase inhibitors. Regioselective synthesis of novel 1-substituted 1,4-dihydro-4-oxo-3-pyridinesulfonamides and their inhibition of the... Eur J Med Chem. 2010 Sep;45(9):3656-61. DMUXSH5 RU https://pubmed.ncbi.nlm.nih.gov/20554082 DMYGZ8V DI DMYGZ8V DMYGZ8V DN 1-Benzyl-1H-1,3,4b,9-tetraaza-fluorene-2,4-dione DMYGZ8V MI TTJFY5U DMYGZ8V MN Adenosine A3 receptor (ADORA3) DMYGZ8V MT DTT DMYGZ8V MA Inhibitor DMYGZ8V RN Pyrido[2,1-f]purine-2,4-dione derivatives as a novel class of highly potent human A(3) adenosine receptor antagonists. J Med Chem. 2002 Aug 1;45(16):3337-44. DMYGZ8V RU https://pubmed.ncbi.nlm.nih.gov/12139445 DM2UFXE DI DM2UFXE DM2UFXE DN 1-benzyl-1H-indole-2,3-dione DM2UFXE MI TTMF541 DM2UFXE MN Liver carboxylesterase (CES1) DM2UFXE MT DTT DM2UFXE MA Inhibitor DM2UFXE RN Selective inhibition of carboxylesterases by isatins, indole-2,3-diones. J Med Chem. 2007 Apr 19;50(8):1876-85. DM2UFXE RU https://pubmed.ncbi.nlm.nih.gov/17378546 DMW0Y92 DI DMW0Y92 DMW0Y92 DN 1-Benzyl-1H-indole-5-carboxamidine DMW0Y92 MI TT2WR1T DMW0Y92 MN Cationic trypsinogen (PRSS1) DMW0Y92 MT DTT DMW0Y92 MA Inhibitor DMW0Y92 RN Aromatic amidines: comparison of their ability to block respiratory syncytial virus induced cell fusion and to inhibit plasmin, urokinase, thrombin... J Med Chem. 1983 Feb;26(2):294-8. DMW0Y92 RU https://pubmed.ncbi.nlm.nih.gov/6219223 DMEVSFY DI DMEVSFY DMEVSFY DN 1-benzyl-1H-pyrrolo[3,2-b]pyridine DMEVSFY MI TTNDSF4 DMEVSFY MN Proto-oncogene c-Met (MET) DMEVSFY MT DTT DMEVSFY MA Inhibitor DMEVSFY RN Discovery of 4-azaindoles as novel inhibitors of c-Met kinase. Bioorg Med Chem Lett. 2009 May 15;19(10):2780-4. DMEVSFY RU https://pubmed.ncbi.nlm.nih.gov/19369077 DMQFS2D DI DMQFS2D DMQFS2D DN 1-benzyl-2,3-dimethyl-1H-indole-7-carboxylic acid DMQFS2D MI TTHWMFZ DMQFS2D MN Fatty acid-binding protein 4 (FABP4) DMQFS2D MT DTT DMQFS2D MA Inhibitor DMQFS2D RN N-Benzyl-indolo carboxylic acids: Design and synthesis of potent and selective adipocyte fatty-acid binding protein (A-FABP) inhibitors. Bioorg Med Chem Lett. 2009 Mar 15;19(6):1745-8. DMQFS2D RU https://pubmed.ncbi.nlm.nih.gov/19217286 DMEVO6M DI DMEVO6M DMEVO6M DN 1-Benzyl-2-methyl-1H-imidazole DMEVO6M MI TTZUFI5 DMEVO6M MN Nitric-oxide synthase brain (NOS1) DMEVO6M MT DTT DMEVO6M MA Inhibitor DMEVO6M RN N-Substituted acetamidines and 2-methylimidazole derivatives as selective inhibitors of neuronal nitric oxide synthase. Bioorg Med Chem Lett. 2010 Nov 15;20(22):6495-9. DMEVO6M RU https://pubmed.ncbi.nlm.nih.gov/20933416 DMPTMKU DI DMPTMKU DMPTMKU DN 1-benzyl-3,3-diethylazetidine-2,4-dione DMPTMKU MI TTPLTSQ DMPTMKU MN Neutrophil elastase (NE) DMPTMKU MT DTT DMPTMKU MA Inhibitor DMPTMKU RN 4-Oxo-beta-lactams (azetidine-2,4-diones) are potent and selective inhibitors of human leukocyte elastase. J Med Chem. 2010 Jan 14;53(1):241-53. DMPTMKU RU https://pubmed.ncbi.nlm.nih.gov/19904934 DMW59XA DI DMW59XA DMW59XA DN 1-benzyl-3,3-dimethylazetidine-2,4-dione DMW59XA MI TTPLTSQ DMW59XA MN Neutrophil elastase (NE) DMW59XA MT DTT DMW59XA MA Inhibitor DMW59XA RN 4-Oxo-beta-lactams (azetidine-2,4-diones) are potent and selective inhibitors of human leukocyte elastase. J Med Chem. 2010 Jan 14;53(1):241-53. DMW59XA RU https://pubmed.ncbi.nlm.nih.gov/19904934 DMMRV21 DI DMMRV21 DMMRV21 DN 1-Benzyl-3-methyl-3,7-dihydro-purine-2,6-dione DMMRV21 MI TTNE7KG DMMRV21 MN Adenosine A2b receptor (ADORA2B) DMMRV21 MT DTT DMMRV21 MA Inhibitor DMMRV21 RN Structure-activity relationships at human and rat A2B adenosine receptors of xanthine derivatives substituted at the 1-, 3-, 7-, and 8-positions. J Med Chem. 2002 May 23;45(11):2131-8. DMMRV21 RU https://pubmed.ncbi.nlm.nih.gov/12014951 DMMRV21 DI DMMRV21 DMMRV21 DN 1-Benzyl-3-methyl-3,7-dihydro-purine-2,6-dione DMMRV21 MI TTJFY5U DMMRV21 MN Adenosine A3 receptor (ADORA3) DMMRV21 MT DTT DMMRV21 MA Inhibitor DMMRV21 RN Structure-activity relationships at human and rat A2B adenosine receptors of xanthine derivatives substituted at the 1-, 3-, 7-, and 8-positions. J Med Chem. 2002 May 23;45(11):2131-8. DMMRV21 RU https://pubmed.ncbi.nlm.nih.gov/12014951 DMMNH4K DI DMMNH4K DMMNH4K DN 1'-Benzyl-3-phenyl-[3,4']bipiperidinyl-2,6-dione DMMNH4K MI TTZ9SOR DMMNH4K MN Muscarinic acetylcholine receptor M1 (CHRM1) DMMNH4K MT DTT DMMNH4K MA Inhibitor DMMNH4K RN Synthesis and biological evaluation of [125I]- and [123I]-4-iododexetimide, a potent muscarinic cholinergic receptor antagonist. J Med Chem. 1989 May;32(5):1057-62. DMMNH4K RU https://pubmed.ncbi.nlm.nih.gov/2785211 DMMNH4K DI DMMNH4K DMMNH4K DN 1'-Benzyl-3-phenyl-[3,4']bipiperidinyl-2,6-dione DMMNH4K MI TTYEG6Q DMMNH4K MN Muscarinic acetylcholine receptor M2 (CHRM2) DMMNH4K MT DTT DMMNH4K MA Inhibitor DMMNH4K RN Synthesis and biological evaluation of [125I]- and [123I]-4-iododexetimide, a potent muscarinic cholinergic receptor antagonist. J Med Chem. 1989 May;32(5):1057-62. DMMNH4K RU https://pubmed.ncbi.nlm.nih.gov/2785211 DMMNH4K DI DMMNH4K DMMNH4K DN 1'-Benzyl-3-phenyl-[3,4']bipiperidinyl-2,6-dione DMMNH4K MI TTQ13Z5 DMMNH4K MN Muscarinic acetylcholine receptor M3 (CHRM3) DMMNH4K MT DTT DMMNH4K MA Inhibitor DMMNH4K RN Synthesis and biological evaluation of [125I]- and [123I]-4-iododexetimide, a potent muscarinic cholinergic receptor antagonist. J Med Chem. 1989 May;32(5):1057-62. DMMNH4K RU https://pubmed.ncbi.nlm.nih.gov/2785211 DMMNH4K DI DMMNH4K DMMNH4K DN 1'-Benzyl-3-phenyl-[3,4']bipiperidinyl-2,6-dione DMMNH4K MI TTQ3JTF DMMNH4K MN Muscarinic acetylcholine receptor M4 (CHRM4) DMMNH4K MT DTT DMMNH4K MA Inhibitor DMMNH4K RN Synthesis and biological evaluation of [125I]- and [123I]-4-iododexetimide, a potent muscarinic cholinergic receptor antagonist. J Med Chem. 1989 May;32(5):1057-62. DMMNH4K RU https://pubmed.ncbi.nlm.nih.gov/2785211 DMMNH4K DI DMMNH4K DMMNH4K DN 1'-Benzyl-3-phenyl-[3,4']bipiperidinyl-2,6-dione DMMNH4K MI TTH18TF DMMNH4K MN Muscarinic acetylcholine receptor M5 (CHRM5) DMMNH4K MT DTT DMMNH4K MA Inhibitor DMMNH4K RN Synthesis and biological evaluation of [125I]- and [123I]-4-iododexetimide, a potent muscarinic cholinergic receptor antagonist. J Med Chem. 1989 May;32(5):1057-62. DMMNH4K RU https://pubmed.ncbi.nlm.nih.gov/2785211 DMV7UC0 DI DMV7UC0 DMV7UC0 DN 1-Benzyl-3-phenylquinazoline-2,4(1H,3H)-dione DMV7UC0 MI TTUV8G9 DMV7UC0 MN Progesterone receptor (PGR) DMV7UC0 MT DTT DMV7UC0 MA Inhibitor DMV7UC0 RN Progesterone receptor antagonists with a 3-phenylquinazoline-2,4-dione/2-phenylisoquinoline-1,3-dione skeleton. Bioorg Med Chem. 2008 Jul 15;16(14):7046-54. DMV7UC0 RU https://pubmed.ncbi.nlm.nih.gov/18586498 DMNWGOE DI DMNWGOE DMNWGOE DN 1-Benzyl-3-thiazol-2-yl-thiourea DMNWGOE MI TT84ETX DMNWGOE MN Human immunodeficiency virus Reverse transcriptase (HIV RT) DMNWGOE MT DTT DMNWGOE MA Inhibitor DMNWGOE RN Phenethylthiazolethiourea (PETT) compounds, a new class of HIV-1 reverse transcriptase inhibitors. 1. Synthesis and basic structure-activity relati... J Med Chem. 1995 Dec 8;38(25):4929-36. DMNWGOE RU https://pubmed.ncbi.nlm.nih.gov/8523406 DMGDY4X DI DMGDY4X DMGDY4X DN 1-benzyl-4-(2,4-dichlorophenyl)pyrrolidin-3-amine DMGDY4X MI TTDIGC1 DMGDY4X MN Dipeptidyl peptidase 4 (DPP-4) DMGDY4X MT DTT DMGDY4X MA Inhibitor DMGDY4X RN Pyrrolidine-constrained phenethylamines: The design of potent, selective, and pharmacologically efficacious dipeptidyl peptidase IV (DPP4) inhibito... Bioorg Med Chem Lett. 2007 Apr 1;17(7):2005-12. DMGDY4X RU https://pubmed.ncbi.nlm.nih.gov/17276063 DMF0GXD DI DMF0GXD DMF0GXD DN 1-Benzyl-4-(2-ethynyl-pyrrol-1-yl)-piperidine DMF0GXD MI TTZFYLI DMF0GXD MN Dopamine D1 receptor (D1R) DMF0GXD MT DTT DMF0GXD MA Inhibitor DMF0GXD RN Piperidinylpyrroles: design, synthesis and binding properties of novel and selective dopamine D4 receptor ligands. Bioorg Med Chem Lett. 1999 Nov 1;9(21):3143-6. DMF0GXD RU https://pubmed.ncbi.nlm.nih.gov/10560741 DMF0GXD DI DMF0GXD DMF0GXD DN 1-Benzyl-4-(2-ethynyl-pyrrol-1-yl)-piperidine DMF0GXD MI TTEX248 DMF0GXD MN Dopamine D2 receptor (D2R) DMF0GXD MT DTT DMF0GXD MA Inhibitor DMF0GXD RN Piperidinylpyrroles: design, synthesis and binding properties of novel and selective dopamine D4 receptor ligands. Bioorg Med Chem Lett. 1999 Nov 1;9(21):3143-6. DMF0GXD RU https://pubmed.ncbi.nlm.nih.gov/10560741 DMF0GXD DI DMF0GXD DMF0GXD DN 1-Benzyl-4-(2-ethynyl-pyrrol-1-yl)-piperidine DMF0GXD MI TT4C8EA DMF0GXD MN Dopamine D3 receptor (D3R) DMF0GXD MT DTT DMF0GXD MA Inhibitor DMF0GXD RN Piperidinylpyrroles: design, synthesis and binding properties of novel and selective dopamine D4 receptor ligands. Bioorg Med Chem Lett. 1999 Nov 1;9(21):3143-6. DMF0GXD RU https://pubmed.ncbi.nlm.nih.gov/10560741 DMF0GXD DI DMF0GXD DMF0GXD DN 1-Benzyl-4-(2-ethynyl-pyrrol-1-yl)-piperidine DMF0GXD MI TTE0A2F DMF0GXD MN Dopamine D4 receptor (D4R) DMF0GXD MT DTT DMF0GXD MA Inhibitor DMF0GXD RN Piperidinylpyrroles: design, synthesis and binding properties of novel and selective dopamine D4 receptor ligands. Bioorg Med Chem Lett. 1999 Nov 1;9(21):3143-6. DMF0GXD RU https://pubmed.ncbi.nlm.nih.gov/10560741 DMBRJ5S DI DMBRJ5S DMBRJ5S DN 1-Benzyl-4-(2-iodo-pyrrol-1-yl)-piperidine DMBRJ5S MI TTZFYLI DMBRJ5S MN Dopamine D1 receptor (D1R) DMBRJ5S MT DTT DMBRJ5S MA Inhibitor DMBRJ5S RN Piperidinylpyrroles: design, synthesis and binding properties of novel and selective dopamine D4 receptor ligands. Bioorg Med Chem Lett. 1999 Nov 1;9(21):3143-6. DMBRJ5S RU https://pubmed.ncbi.nlm.nih.gov/10560741 DMBRJ5S DI DMBRJ5S DMBRJ5S DN 1-Benzyl-4-(2-iodo-pyrrol-1-yl)-piperidine DMBRJ5S MI TTEX248 DMBRJ5S MN Dopamine D2 receptor (D2R) DMBRJ5S MT DTT DMBRJ5S MA Inhibitor DMBRJ5S RN Piperidinylpyrroles: design, synthesis and binding properties of novel and selective dopamine D4 receptor ligands. Bioorg Med Chem Lett. 1999 Nov 1;9(21):3143-6. DMBRJ5S RU https://pubmed.ncbi.nlm.nih.gov/10560741 DMBRJ5S DI DMBRJ5S DMBRJ5S DN 1-Benzyl-4-(2-iodo-pyrrol-1-yl)-piperidine DMBRJ5S MI TT4C8EA DMBRJ5S MN Dopamine D3 receptor (D3R) DMBRJ5S MT DTT DMBRJ5S MA Inhibitor DMBRJ5S RN Piperidinylpyrroles: design, synthesis and binding properties of novel and selective dopamine D4 receptor ligands. Bioorg Med Chem Lett. 1999 Nov 1;9(21):3143-6. DMBRJ5S RU https://pubmed.ncbi.nlm.nih.gov/10560741 DMBRJ5S DI DMBRJ5S DMBRJ5S DN 1-Benzyl-4-(2-iodo-pyrrol-1-yl)-piperidine DMBRJ5S MI TTE0A2F DMBRJ5S MN Dopamine D4 receptor (D4R) DMBRJ5S MT DTT DMBRJ5S MA Inhibitor DMBRJ5S RN Piperidinylpyrroles: design, synthesis and binding properties of novel and selective dopamine D4 receptor ligands. Bioorg Med Chem Lett. 1999 Nov 1;9(21):3143-6. DMBRJ5S RU https://pubmed.ncbi.nlm.nih.gov/10560741 DMSBNY8 DI DMSBNY8 DMSBNY8 DN 1-Benzyl-4-(2-oxazol-5-yl-pyrrol-1-yl)-piperidine DMSBNY8 MI TTZFYLI DMSBNY8 MN Dopamine D1 receptor (D1R) DMSBNY8 MT DTT DMSBNY8 MA Inhibitor DMSBNY8 RN Piperidinylpyrroles: design, synthesis and binding properties of novel and selective dopamine D4 receptor ligands. Bioorg Med Chem Lett. 1999 Nov 1;9(21):3143-6. DMSBNY8 RU https://pubmed.ncbi.nlm.nih.gov/10560741 DMSBNY8 DI DMSBNY8 DMSBNY8 DN 1-Benzyl-4-(2-oxazol-5-yl-pyrrol-1-yl)-piperidine DMSBNY8 MI TTEX248 DMSBNY8 MN Dopamine D2 receptor (D2R) DMSBNY8 MT DTT DMSBNY8 MA Inhibitor DMSBNY8 RN Piperidinylpyrroles: design, synthesis and binding properties of novel and selective dopamine D4 receptor ligands. Bioorg Med Chem Lett. 1999 Nov 1;9(21):3143-6. DMSBNY8 RU https://pubmed.ncbi.nlm.nih.gov/10560741 DMSBNY8 DI DMSBNY8 DMSBNY8 DN 1-Benzyl-4-(2-oxazol-5-yl-pyrrol-1-yl)-piperidine DMSBNY8 MI TT4C8EA DMSBNY8 MN Dopamine D3 receptor (D3R) DMSBNY8 MT DTT DMSBNY8 MA Inhibitor DMSBNY8 RN Piperidinylpyrroles: design, synthesis and binding properties of novel and selective dopamine D4 receptor ligands. Bioorg Med Chem Lett. 1999 Nov 1;9(21):3143-6. DMSBNY8 RU https://pubmed.ncbi.nlm.nih.gov/10560741 DMSBNY8 DI DMSBNY8 DMSBNY8 DN 1-Benzyl-4-(2-oxazol-5-yl-pyrrol-1-yl)-piperidine DMSBNY8 MI TTE0A2F DMSBNY8 MN Dopamine D4 receptor (D4R) DMSBNY8 MT DTT DMSBNY8 MA Inhibitor DMSBNY8 RN Piperidinylpyrroles: design, synthesis and binding properties of novel and selective dopamine D4 receptor ligands. Bioorg Med Chem Lett. 1999 Nov 1;9(21):3143-6. DMSBNY8 RU https://pubmed.ncbi.nlm.nih.gov/10560741 DMCO0JU DI DMCO0JU DMCO0JU DN 1-Benzyl-4-(3-hydroxyphenyl)piperidine DMCO0JU MI TTEX248 DMCO0JU MN Dopamine D2 receptor (D2R) DMCO0JU MT DTT DMCO0JU MA Inhibitor DMCO0JU RN Synthesis and evaluation of a set of 4-phenylpiperidines and 4-phenylpiperazines as D2 receptor ligands and the discovery of the dopaminergic stabi... J Med Chem. 2010 Mar 25;53(6):2510-20. DMCO0JU RU https://pubmed.ncbi.nlm.nih.gov/20155917 DMCJZVA DI DMCJZVA DMCJZVA DN 1-Benzyl-4-(3-oxazol-5-yl-pyrrol-1-yl)-piperidine DMCJZVA MI TTEX248 DMCJZVA MN Dopamine D2 receptor (D2R) DMCJZVA MT DTT DMCJZVA MA Inhibitor DMCJZVA RN Piperidinylpyrroles: design, synthesis and binding properties of novel and selective dopamine D4 receptor ligands. Bioorg Med Chem Lett. 1999 Nov 1;9(21):3143-6. DMCJZVA RU https://pubmed.ncbi.nlm.nih.gov/10560741 DMCJZVA DI DMCJZVA DMCJZVA DN 1-Benzyl-4-(3-oxazol-5-yl-pyrrol-1-yl)-piperidine DMCJZVA MI TT4C8EA DMCJZVA MN Dopamine D3 receptor (D3R) DMCJZVA MT DTT DMCJZVA MA Inhibitor DMCJZVA RN Piperidinylpyrroles: design, synthesis and binding properties of novel and selective dopamine D4 receptor ligands. Bioorg Med Chem Lett. 1999 Nov 1;9(21):3143-6. DMCJZVA RU https://pubmed.ncbi.nlm.nih.gov/10560741 DMCJZVA DI DMCJZVA DMCJZVA DN 1-Benzyl-4-(3-oxazol-5-yl-pyrrol-1-yl)-piperidine DMCJZVA MI TTE0A2F DMCJZVA MN Dopamine D4 receptor (D4R) DMCJZVA MT DTT DMCJZVA MA Inhibitor DMCJZVA RN Piperidinylpyrroles: design, synthesis and binding properties of novel and selective dopamine D4 receptor ligands. Bioorg Med Chem Lett. 1999 Nov 1;9(21):3143-6. DMCJZVA RU https://pubmed.ncbi.nlm.nih.gov/10560741 DM4NGUL DI DM4NGUL DM4NGUL DN 1-Benzyl-4-(4-phenylpiperazin-1-yl)phthalazine DM4NGUL MI TT8J1S3 DM4NGUL MN Smoothened homolog (SMO) DM4NGUL MT DTT DM4NGUL MA Inhibitor DM4NGUL RN 1-amino-4-benzylphthalazines as orally bioavailable smoothened antagonists with antitumor activity. J Med Chem. 2009 Jul 9;52(13):3954-68. DM4NGUL RU https://pubmed.ncbi.nlm.nih.gov/19469545 DMOF07G DI DMOF07G DMOF07G DN 1-Benzyl-4-[3-(methylsulfonyl)phenyl]piperazine DMOF07G MI TTEX248 DMOF07G MN Dopamine D2 receptor (D2R) DMOF07G MT DTT DMOF07G MA Inhibitor DMOF07G RN Synthesis and evaluation of a set of 4-phenylpiperidines and 4-phenylpiperazines as D2 receptor ligands and the discovery of the dopaminergic stabi... J Med Chem. 2010 Mar 25;53(6):2510-20. DMOF07G RU https://pubmed.ncbi.nlm.nih.gov/20155917 DME0MDL DI DME0MDL DME0MDL DN 1-Benzyl-4-[3-(methylsulfonyl)phenyl]piperidine DME0MDL MI TTEX248 DME0MDL MN Dopamine D2 receptor (D2R) DME0MDL MT DTT DME0MDL MA Inhibitor DME0MDL RN Synthesis and evaluation of a set of 4-phenylpiperidines and 4-phenylpiperazines as D2 receptor ligands and the discovery of the dopaminergic stabi... J Med Chem. 2010 Mar 25;53(6):2510-20. DME0MDL RU https://pubmed.ncbi.nlm.nih.gov/20155917 DMAQSBV DI DMAQSBV DMAQSBV DN 1-Benzyl-4-chroman-2-ylmethyl-piperazine DMAQSBV MI TTSQIFT DMAQSBV MN 5-HT 1A receptor (HTR1A) DMAQSBV MT DTT DMAQSBV MA Inhibitor DMAQSBV RN Synthesis and structure-activity relationships of 1-aralkyl-4-benzylpiperidine and 1-aralkyl-4-benzylpiperazine derivatives as potent sigma ligands. J Med Chem. 2005 Jan 13;48(1):266-73. DMAQSBV RU https://pubmed.ncbi.nlm.nih.gov/15634021 DMETDQC DI DMETDQC DMETDQC DN 1-Benzyl-4-methyl-piperazine DMETDQC MI TTD0CIQ DMETDQC MN Melanocortin receptor 4 (MC4R) DMETDQC MT DTT DMETDQC MA Inhibitor DMETDQC RN Privileged structure based ligands for melanocortin receptors--substituted benzylic piperazine derivatives. Bioorg Med Chem Lett. 2005 Nov 15;15(22):4973-8. DMETDQC RU https://pubmed.ncbi.nlm.nih.gov/16169215 DMNTELW DI DMNTELW DMNTELW DN 1-benzyl-4-phenylpiperidin-4-ol DMNTELW MI TTNT7K8 DMNTELW MN Nociceptin receptor (OPRL1) DMNTELW MT DTT DMNTELW MA Inhibitor DMNTELW RN Bioorg Med Chem Lett. 2007 Jun 1;17(11):3023-7. Epub 2007 Mar 23.Synthesis and structure-activity relationships of 4-hydroxy-4-phenylpiperidines as nociceptin receptor ligands: Part 1. DMNTELW RU https://pubmed.ncbi.nlm.nih.gov/17428659 DMNWEC9 DI DMNWEC9 DMNWEC9 DN 1-Benzyl-4-pyrrol-1-yl-piperidine DMNWEC9 MI TTEX248 DMNWEC9 MN Dopamine D2 receptor (D2R) DMNWEC9 MT DTT DMNWEC9 MA Inhibitor DMNWEC9 RN Piperidinylpyrroles: design, synthesis and binding properties of novel and selective dopamine D4 receptor ligands. Bioorg Med Chem Lett. 1999 Nov 1;9(21):3143-6. DMNWEC9 RU https://pubmed.ncbi.nlm.nih.gov/10560741 DMNWEC9 DI DMNWEC9 DMNWEC9 DN 1-Benzyl-4-pyrrol-1-yl-piperidine DMNWEC9 MI TT4C8EA DMNWEC9 MN Dopamine D3 receptor (D3R) DMNWEC9 MT DTT DMNWEC9 MA Inhibitor DMNWEC9 RN Piperidinylpyrroles: design, synthesis and binding properties of novel and selective dopamine D4 receptor ligands. Bioorg Med Chem Lett. 1999 Nov 1;9(21):3143-6. DMNWEC9 RU https://pubmed.ncbi.nlm.nih.gov/10560741 DMNWEC9 DI DMNWEC9 DMNWEC9 DN 1-Benzyl-4-pyrrol-1-yl-piperidine DMNWEC9 MI TTE0A2F DMNWEC9 MN Dopamine D4 receptor (D4R) DMNWEC9 MT DTT DMNWEC9 MA Inhibitor DMNWEC9 RN Piperidinylpyrroles: design, synthesis and binding properties of novel and selective dopamine D4 receptor ligands. Bioorg Med Chem Lett. 1999 Nov 1;9(21):3143-6. DMNWEC9 RU https://pubmed.ncbi.nlm.nih.gov/10560741 DMH0ZVR DI DMH0ZVR DMH0ZVR DN 1-benzyl-5'-O-tritylinosine DMH0ZVR MI TTO0IB8 DMH0ZVR MN Thymidine phosphorylase (TYMP) DMH0ZVR MT DTT DMH0ZVR MA Inhibitor DMH0ZVR RN 5'-O-tritylinosine and analogues as allosteric inhibitors of human thymidine phosphorylase. J Med Chem. 2006 Sep 7;49(18):5562-70. DMH0ZVR RU https://pubmed.ncbi.nlm.nih.gov/16942029 DM8GUN9 DI DM8GUN9 DM8GUN9 DN 1-Benzyl-5-phenyl-1H-imidazole DM8GUN9 MI TTIQUX7 DM8GUN9 MN Steroid 11-beta-hydroxylase (CYP11B1) DM8GUN9 MT DTT DM8GUN9 MA Inhibitor DM8GUN9 RN Synthesis, biological evaluation, and molecular modeling of 1-benzyl-1H-imidazoles as selective inhibitors of aldosterone synthase (CYP11B2). J Med Chem. 2010 Feb 25;53(4):1712-25. DM8GUN9 RU https://pubmed.ncbi.nlm.nih.gov/20121113 DMCX3N1 DI DMCX3N1 DMCX3N1 DN 1-Benzyl-7-chloro-4-hexyloxy-quinolinium DMCX3N1 MI TTY3UE6 DMCX3N1 MN Voltage-gated potassium channel Kv1.3 (KCNA3) DMCX3N1 MT DTT DMCX3N1 MA Inhibitor DMCX3N1 RN Novel inhibitors of potassium ion channels on human T lymphocytes. J Med Chem. 1995 May 26;38(11):1877-83. DMCX3N1 RU https://pubmed.ncbi.nlm.nih.gov/7540207 DMJHXMY DI DMJHXMY DMJHXMY DN 1-benzyl-APDC DMJHXMY MI TTWRP2F DMJHXMY MN Metabotropic glutamate receptor 6 (mGluR6) DMJHXMY MT DTT DMJHXMY MA Agonist DMJHXMY RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 294). DMJHXMY RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=294 DM7GDEK DI DM7GDEK DM7GDEK DN 1-benzylpiperidine hydrochloride DM7GDEK MI TTVBI8W DM7GDEK MN Dopamine transporter (DAT) DM7GDEK MT DTT DM7GDEK MA Inhibitor DM7GDEK RN Synthesis and pharmacology of site-specific cocaine abuse treatment agents: restricted rotation analogues of methylphenidate. J Med Chem. 2007 May 31;50(11):2718-31. DM7GDEK RU https://pubmed.ncbi.nlm.nih.gov/17489581 DM7GDEK DI DM7GDEK DM7GDEK DN 1-benzylpiperidine hydrochloride DM7GDEK MI TT3ROYC DM7GDEK MN Serotonin transporter (SERT) DM7GDEK MT DTT DM7GDEK MA Inhibitor DM7GDEK RN Synthesis and pharmacology of site-specific cocaine abuse treatment agents: restricted rotation analogues of methylphenidate. J Med Chem. 2007 May 31;50(11):2718-31. DM7GDEK RU https://pubmed.ncbi.nlm.nih.gov/17489581 DMHR90S DI DMHR90S DMHR90S DN 1beta-methoxy-miller-9Z-enolide DMHR90S MI TTSXVID DMHR90S MN Nuclear factor NF-kappa-B (NFKB) DMHR90S MT DTT DMHR90S MA Inhibitor DMHR90S RN Development of a structural model for NF-kappaB inhibition of sesquiterpene lactones using self-organizing neural networks. J Med Chem. 2006 Apr 6;49(7):2241-52. DMHR90S RU https://pubmed.ncbi.nlm.nih.gov/16570920 DMKJYCU DI DMKJYCU DMKJYCU DN 1-biphenyl-2-ylmethanamine DMKJYCU MI TTDIGC1 DMKJYCU MN Dipeptidyl peptidase 4 (DPP-4) DMKJYCU MT DTT DMKJYCU MA Inhibitor DMKJYCU RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DMKJYCU RU https://pubmed.ncbi.nlm.nih.gov/10592235 DM6E7TA DI DM6E7TA DM6E7TA DN 1-Biphenyl-4-yl-3-aza-bicyclo[3.1.0]hexane DM6E7TA MI TTVBI8W DM6E7TA MN Dopamine transporter (DAT) DM6E7TA MT DTT DM6E7TA MA Inhibitor DM6E7TA RN Studies on the structure-activity relationship of bicifadine analogs as monoamine transporter inhibitors. Bioorg Med Chem Lett. 2008 Jul 1;18(13):3682-6. DM6E7TA RU https://pubmed.ncbi.nlm.nih.gov/18539031 DM6E7TA DI DM6E7TA DM6E7TA DN 1-Biphenyl-4-yl-3-aza-bicyclo[3.1.0]hexane DM6E7TA MI TT3ROYC DM6E7TA MN Serotonin transporter (SERT) DM6E7TA MT DTT DM6E7TA MA Inhibitor DM6E7TA RN Studies on the structure-activity relationship of bicifadine analogs as monoamine transporter inhibitors. Bioorg Med Chem Lett. 2008 Jul 1;18(13):3682-6. DM6E7TA RU https://pubmed.ncbi.nlm.nih.gov/18539031 DM9QTWB DI DM9QTWB DM9QTWB DN 1-Biphenyl-4-ylmaleimide DM9QTWB MI TTDP1UC DM9QTWB MN Fatty acid amide hydrolase (FAAH) DM9QTWB MT DTT DM9QTWB MA Inhibitor DM9QTWB RN Synthesis and in vitro evaluation of N-substituted maleimide derivatives as selective monoglyceride lipase inhibitors. J Med Chem. 2009 Dec 10;52(23):7410-20. DM9QTWB RU https://pubmed.ncbi.nlm.nih.gov/19583260 DMKL201 DI DMKL201 DMKL201 DN 1-Biphenyl-4-ylmethylmaleimide DMKL201 MI TTDP1UC DMKL201 MN Fatty acid amide hydrolase (FAAH) DMKL201 MT DTT DMKL201 MA Inhibitor DMKL201 RN Synthesis and in vitro evaluation of N-substituted maleimide derivatives as selective monoglyceride lipase inhibitors. J Med Chem. 2009 Dec 10;52(23):7410-20. DMKL201 RU https://pubmed.ncbi.nlm.nih.gov/19583260 DMGL4MJ DI DMGL4MJ DMGL4MJ DN 1-Bromo-4-imidazol-1-ylmethyl-xanthen-9-one DMGL4MJ MI TTSZLWK DMGL4MJ MN Aromatase (CYP19A1) DMGL4MJ MT DTT DMGL4MJ MA Inhibitor DMGL4MJ RN A new class of nonsteroidal aromatase inhibitors: design and synthesis of chromone and xanthone derivatives and inhibition of the P450 enzymes aromatase and 17 alpha-hydroxylase/C17,20-lyase. J Med Chem. 2001 Mar 1;44(5):672-80. DMGL4MJ RU https://pubmed.ncbi.nlm.nih.gov/11262078 DMU2PSQ DI DMU2PSQ DMU2PSQ DN 1-Bromo-6-(3-hydroxyphenyl)-2-naphthol DMU2PSQ MI TTIWB6L DMU2PSQ MN Estradiol 17 beta-dehydrogenase 1 (17-beta-HSD1) DMU2PSQ MT DTT DMU2PSQ MA Inhibitor DMU2PSQ RN Substituted 6-phenyl-2-naphthols. Potent and selective nonsteroidal inhibitors of 17beta-hydroxysteroid dehydrogenase type 1 (17beta-HSD1): design,... J Med Chem. 2008 Aug 14;51(15):4685-98. DMU2PSQ RU https://pubmed.ncbi.nlm.nih.gov/18630892 DM2T4NL DI DM2T4NL DM2T4NL DN 1-Bromo-6-(4-hydroxy-phenyl)-naphthalen-2-ol DM2T4NL MI TTZAYWL DM2T4NL MN Estrogen receptor (ESR) DM2T4NL MT DTT DM2T4NL MA Inhibitor DM2T4NL RN ERbeta ligands. 3. Exploiting two binding orientations of the 2-phenylnaphthalene scaffold to achieve ERbeta selectivity. J Med Chem. 2005 Jun 16;48(12):3953-79. DM2T4NL RU https://pubmed.ncbi.nlm.nih.gov/15943471 DM2T4NL DI DM2T4NL DM2T4NL DN 1-Bromo-6-(4-hydroxy-phenyl)-naphthalen-2-ol DM2T4NL MI TTOM3J0 DM2T4NL MN Estrogen receptor beta (ESR2) DM2T4NL MT DTT DM2T4NL MA Inhibitor DM2T4NL RN ERbeta ligands. 3. Exploiting two binding orientations of the 2-phenylnaphthalene scaffold to achieve ERbeta selectivity. J Med Chem. 2005 Jun 16;48(12):3953-79. DM2T4NL RU https://pubmed.ncbi.nlm.nih.gov/15943471 DMXMATS DI DMXMATS DMXMATS DN 1-butoxy-4-phenoxybenzene DMXMATS MI TTXZEAJ DMXMATS MN Leukotriene A-4 hydrolase (LTA4H) DMXMATS MT DTT DMXMATS MA Inhibitor DMXMATS RN Activation and inhibition of leukotriene A4 hydrolase aminopeptidase activity by diphenyl ether and derivatives. Bioorg Med Chem Lett. 2008 Dec 15;18(24):6549-52. DMXMATS RU https://pubmed.ncbi.nlm.nih.gov/18952425 DMO7NXE DI DMO7NXE DMO7NXE DN 1-Butyl-3-(2-dimethylamino-ethyl)-1H-indol-4-ol DMO7NXE MI TTJQOD7 DMO7NXE MN 5-HT 2A receptor (HTR2A) DMO7NXE MT DTT DMO7NXE MA Inhibitor DMO7NXE RN SAR of psilocybin analogs: discovery of a selective 5-HT 2C agonist. Bioorg Med Chem Lett. 2005 Oct 15;15(20):4555-9. DMO7NXE RU https://pubmed.ncbi.nlm.nih.gov/16061378 DMO7NXE DI DMO7NXE DMO7NXE DN 1-Butyl-3-(2-dimethylamino-ethyl)-1H-indol-4-ol DMO7NXE MI TT0K1SC DMO7NXE MN 5-HT 2B receptor (HTR2B) DMO7NXE MT DTT DMO7NXE MA Inhibitor DMO7NXE RN SAR of psilocybin analogs: discovery of a selective 5-HT 2C agonist. Bioorg Med Chem Lett. 2005 Oct 15;15(20):4555-9. DMO7NXE RU https://pubmed.ncbi.nlm.nih.gov/16061378 DMO7NXE DI DMO7NXE DMO7NXE DN 1-Butyl-3-(2-dimethylamino-ethyl)-1H-indol-4-ol DMO7NXE MI TTWJBZ5 DMO7NXE MN 5-HT 2C receptor (HTR2C) DMO7NXE MT DTT DMO7NXE MA Inhibitor DMO7NXE RN SAR of psilocybin analogs: discovery of a selective 5-HT 2C agonist. Bioorg Med Chem Lett. 2005 Oct 15;15(20):4555-9. DMO7NXE RU https://pubmed.ncbi.nlm.nih.gov/16061378 DMOE2ZV DI DMOE2ZV DMOE2ZV DN 1-Butyl-3,7-dihydro-purine-2,6-dione DMOE2ZV MI TTJFY5U DMOE2ZV MN Adenosine A3 receptor (ADORA3) DMOE2ZV MT DTT DMOE2ZV MA Inhibitor DMOE2ZV RN Structure-activity relationships at human and rat A2B adenosine receptors of xanthine derivatives substituted at the 1-, 3-, 7-, and 8-positions. J Med Chem. 2002 May 23;45(11):2131-8. DMOE2ZV RU https://pubmed.ncbi.nlm.nih.gov/12014951 DM9GRN8 DI DM9GRN8 DM9GRN8 DN 1-Butyl-3-methyl-3,7-dihydro-purine-2,6-dione DM9GRN8 MI TTZ97H5 DM9GRN8 MN Phosphodiesterase 4A (PDE4A) DM9GRN8 MT DTT DM9GRN8 MA Inhibitor DM9GRN8 RN Effects of alkyl substitutions of xanthine skeleton on bronchodilation. J Med Chem. 1992 Oct 30;35(22):4039-44. DM9GRN8 RU https://pubmed.ncbi.nlm.nih.gov/1331453 DM9GRN8 DI DM9GRN8 DM9GRN8 DN 1-Butyl-3-methyl-3,7-dihydro-purine-2,6-dione DM9GRN8 MI TTSKMI8 DM9GRN8 MN Phosphodiesterase 4D (PDE4D) DM9GRN8 MT DTT DM9GRN8 MA Inhibitor DM9GRN8 RN Effects of alkyl substitutions of xanthine skeleton on bronchodilation. J Med Chem. 1992 Oct 30;35(22):4039-44. DM9GRN8 RU https://pubmed.ncbi.nlm.nih.gov/1331453 DM6QULO DI DM6QULO DM6QULO DN 1-Butyl-4-(2-methoxy-phenyl)-piperazine DM6QULO MI TTSQIFT DM6QULO MN 5-HT 1A receptor (HTR1A) DM6QULO MT DTT DM6QULO MA Inhibitor DM6QULO RN Structure-activity relationship studies of central nervous system agents. 13. 4-[3-(Benzotriazol-1-yl)propyl]-1-(2-methoxyphenyl)piperazine, a new ... J Med Chem. 1994 Aug 19;37(17):2754-60. DM6QULO RU https://pubmed.ncbi.nlm.nih.gov/8064802 DM6QULO DI DM6QULO DM6QULO DN 1-Butyl-4-(2-methoxy-phenyl)-piperazine DM6QULO MI TTJQOD7 DM6QULO MN 5-HT 2A receptor (HTR2A) DM6QULO MT DTT DM6QULO MA Inhibitor DM6QULO RN Structure-activity relationship studies of central nervous system agents. 13. 4-[3-(Benzotriazol-1-yl)propyl]-1-(2-methoxyphenyl)piperazine, a new ... J Med Chem. 1994 Aug 19;37(17):2754-60. DM6QULO RU https://pubmed.ncbi.nlm.nih.gov/8064802 DMSNK98 DI DMSNK98 DMSNK98 DN 1-Butyl-8-phenyl-3,7-dihydro-purine-2,6-dione DMSNK98 MI TTK25J1 DMSNK98 MN Adenosine A1 receptor (ADORA1) DMSNK98 MT DTT DMSNK98 MA Inhibitor DMSNK98 RN Preparation, properties, reactions, and adenosine receptor affinities of sulfophenylxanthine nitrophenyl esters: toward the development of sulfonic... J Med Chem. 2004 Feb 12;47(4):1031-43. DMSNK98 RU https://pubmed.ncbi.nlm.nih.gov/14761205 DMSNK98 DI DMSNK98 DMSNK98 DN 1-Butyl-8-phenyl-3,7-dihydro-purine-2,6-dione DMSNK98 MI TTM2AOE DMSNK98 MN Adenosine A2a receptor (ADORA2A) DMSNK98 MT DTT DMSNK98 MA Inhibitor DMSNK98 RN Preparation, properties, reactions, and adenosine receptor affinities of sulfophenylxanthine nitrophenyl esters: toward the development of sulfonic... J Med Chem. 2004 Feb 12;47(4):1031-43. DMSNK98 RU https://pubmed.ncbi.nlm.nih.gov/14761205 DMSNK98 DI DMSNK98 DMSNK98 DN 1-Butyl-8-phenyl-3,7-dihydro-purine-2,6-dione DMSNK98 MI TTNE7KG DMSNK98 MN Adenosine A2b receptor (ADORA2B) DMSNK98 MT DTT DMSNK98 MA Inhibitor DMSNK98 RN Preparation, properties, reactions, and adenosine receptor affinities of sulfophenylxanthine nitrophenyl esters: toward the development of sulfonic... J Med Chem. 2004 Feb 12;47(4):1031-43. DMSNK98 RU https://pubmed.ncbi.nlm.nih.gov/14761205 DMVFCLO DI DMVFCLO DMVFCLO DN 1-butyryl-1H-indole-2,3-dione DMVFCLO MI TTMF541 DMVFCLO MN Liver carboxylesterase (CES1) DMVFCLO MT DTT DMVFCLO MA Inhibitor DMVFCLO RN Selective inhibition of carboxylesterases by isatins, indole-2,3-diones. J Med Chem. 2007 Apr 19;50(8):1876-85. DMVFCLO RU https://pubmed.ncbi.nlm.nih.gov/17378546 DM13HGN DI DM13HGN DM13HGN DN 1-Chloro-4-(1-phenyl-cyclohexanesulfonyl)-benzene DM13HGN MI TTZ3S8C DM13HGN MN Presenilin 1 (PSEN1) DM13HGN MT DTT DM13HGN MA Inhibitor DM13HGN RN Aryl sulfones: a new class of gamma-secretase inhibitors. Bioorg Med Chem Lett. 2005 May 16;15(10):2685-8. DM13HGN RU https://pubmed.ncbi.nlm.nih.gov/15863342 DM13HGN DI DM13HGN DM13HGN DN 1-Chloro-4-(1-phenyl-cyclohexanesulfonyl)-benzene DM13HGN MI TTWN3F4 DM13HGN MN Presenilin 2 (PSEN2) DM13HGN MT DTT DM13HGN MA Inhibitor DM13HGN RN Aryl sulfones: a new class of gamma-secretase inhibitors. Bioorg Med Chem Lett. 2005 May 16;15(10):2685-8. DM13HGN RU https://pubmed.ncbi.nlm.nih.gov/15863342 DM0MGFQ DI DM0MGFQ DM0MGFQ DN 1-CHLORO-6-(4-HYDROXYPHENYL)-2-NAPHTHOL DM0MGFQ MI TTZAYWL DM0MGFQ MN Estrogen receptor (ESR) DM0MGFQ MT DTT DM0MGFQ MA Inhibitor DM0MGFQ RN ERbeta ligands. 3. Exploiting two binding orientations of the 2-phenylnaphthalene scaffold to achieve ERbeta selectivity. J Med Chem. 2005 Jun 16;48(12):3953-79. DM0MGFQ RU https://pubmed.ncbi.nlm.nih.gov/15943471 DM0MGFQ DI DM0MGFQ DM0MGFQ DN 1-CHLORO-6-(4-HYDROXYPHENYL)-2-NAPHTHOL DM0MGFQ MI TTOM3J0 DM0MGFQ MN Estrogen receptor beta (ESR2) DM0MGFQ MT DTT DM0MGFQ MA Inhibitor DM0MGFQ RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DM0MGFQ RU https://pubmed.ncbi.nlm.nih.gov/10592235 DMA2607 DI DMA2607 DMA2607 DN 1-Cycloheptyl-3-(1-propionylpiperidin-4-yl)urea DMA2607 MI TT7WVHI DMA2607 MN Soluble epoxide hydrolase (EPHX2) DMA2607 MT DTT DMA2607 MA Inhibitor DMA2607 RN 1-Aryl-3-(1-acylpiperidin-4-yl)urea inhibitors of human and murine soluble epoxide hydrolase: structure-activity relationships, pharmacokinetics, a... J Med Chem. 2010 Oct 14;53(19):7067-75. DMA2607 RU https://pubmed.ncbi.nlm.nih.gov/20812725 DMS10LE DI DMS10LE DMS10LE DN 1-cyclohexyl-1-isopropyl-3,3-dimethylselenourea DMS10LE MI TTAS2UO DMS10LE MN Bacterial Urease (Bact ureC) DMS10LE MT DTT DMS10LE MA Inhibitor DMS10LE RN Facile one-pot synthesis of thio and selenourea derivatives: a new class of potent urease inhibitors. Bioorg Med Chem Lett. 2007 Nov 15;17(22):6387-91. DMS10LE RU https://pubmed.ncbi.nlm.nih.gov/17889535 DMAZYCD DI DMAZYCD DMAZYCD DN 1-Cyclohexyl-3-(1-propionylpiperidin-4-yl)urea DMAZYCD MI TT7WVHI DMAZYCD MN Soluble epoxide hydrolase (EPHX2) DMAZYCD MT DTT DMAZYCD MA Inhibitor DMAZYCD RN 1-Aryl-3-(1-acylpiperidin-4-yl)urea inhibitors of human and murine soluble epoxide hydrolase: structure-activity relationships, pharmacokinetics, a... J Med Chem. 2010 Oct 14;53(19):7067-75. DMAZYCD RU https://pubmed.ncbi.nlm.nih.gov/20812725 DMESUD7 DI DMESUD7 DMESUD7 DN 1-Cyclohexyl-3-(4-methoxy-phenyl)-urea DMESUD7 MI TT7WVHI DMESUD7 MN Soluble epoxide hydrolase (EPHX2) DMESUD7 MT DTT DMESUD7 MA Inhibitor DMESUD7 RN Optimization of amide-based inhibitors of soluble epoxide hydrolase with improved water solubility. J Med Chem. 2005 May 19;48(10):3621-9. DMESUD7 RU https://pubmed.ncbi.nlm.nih.gov/15887969 DMH9O6V DI DMH9O6V DMH9O6V DN 1-Cyclohexyl-3-phenethyl-urea DMH9O6V MI TT7WVHI DMH9O6V MN Soluble epoxide hydrolase (EPHX2) DMH9O6V MT DTT DMH9O6V MA Inhibitor DMH9O6V RN Optimization of amide-based inhibitors of soluble epoxide hydrolase with improved water solubility. J Med Chem. 2005 May 19;48(10):3621-9. DMH9O6V RU https://pubmed.ncbi.nlm.nih.gov/15887969 DM9K8HA DI DM9K8HA DM9K8HA DN 1-Cyclohexyl-3-phenyl-urea DM9K8HA MI TT7WVHI DM9K8HA MN Soluble epoxide hydrolase (EPHX2) DM9K8HA MT DTT DM9K8HA MA Inhibitor DM9K8HA RN Optimization of amide-based inhibitors of soluble epoxide hydrolase with improved water solubility. J Med Chem. 2005 May 19;48(10):3621-9. DM9K8HA RU https://pubmed.ncbi.nlm.nih.gov/15887969 DMFPQME DI DMFPQME DMFPQME DN 1-cyclohexylamido-5-sulfonamidoindane DMFPQME MI TTHQPL7 DMFPQME MN Carbonic anhydrase I (CA-I) DMFPQME MT DTT DMFPQME MA Inhibitor DMFPQME RN Indanesulfonamides as carbonic anhydrase inhibitors. Toward structure-based design of selective inhibitors of the tumor-associated isozyme CA IX. J Med Chem. 2006 May 4;49(9):2743-9. DMFPQME RU https://pubmed.ncbi.nlm.nih.gov/16640335 DMFPQME DI DMFPQME DMFPQME DN 1-cyclohexylamido-5-sulfonamidoindane DMFPQME MI TTANPDJ DMFPQME MN Carbonic anhydrase II (CA-II) DMFPQME MT DTT DMFPQME MA Inhibitor DMFPQME RN Indanesulfonamides as carbonic anhydrase inhibitors. Toward structure-based design of selective inhibitors of the tumor-associated isozyme CA IX. J Med Chem. 2006 May 4;49(9):2743-9. DMFPQME RU https://pubmed.ncbi.nlm.nih.gov/16640335 DMFPQME DI DMFPQME DMFPQME DN 1-cyclohexylamido-5-sulfonamidoindane DMFPQME MI TT2LVK8 DMFPQME MN Carbonic anhydrase IX (CA-IX) DMFPQME MT DTT DMFPQME MA Inhibitor DMFPQME RN Indanesulfonamides as carbonic anhydrase inhibitors. Toward structure-based design of selective inhibitors of the tumor-associated isozyme CA IX. J Med Chem. 2006 May 4;49(9):2743-9. DMFPQME RU https://pubmed.ncbi.nlm.nih.gov/16640335 DM7A50Z DI DM7A50Z DM7A50Z DN 1-Cyclohexylidenethiosemicarbazide DM7A50Z MI TTULVH8 DM7A50Z MN Tyrosinase (TYR) DM7A50Z MT DTT DM7A50Z MA Inhibitor DM7A50Z RN A class of potent tyrosinase inhibitors: alkylidenethiosemicarbazide compounds. Eur J Med Chem. 2009 Apr;44(4):1773-8. DM7A50Z RU https://pubmed.ncbi.nlm.nih.gov/18524420 DMEMQFH DI DMEMQFH DMEMQFH DN 1-Cyclopentyl-3,7-dihydro-purine-2,6-dione DMEMQFH MI TTJFY5U DMEMQFH MN Adenosine A3 receptor (ADORA3) DMEMQFH MT DTT DMEMQFH MA Inhibitor DMEMQFH RN Structure-activity relationships at human and rat A2B adenosine receptors of xanthine derivatives substituted at the 1-, 3-, 7-, and 8-positions. J Med Chem. 2002 May 23;45(11):2131-8. DMEMQFH RU https://pubmed.ncbi.nlm.nih.gov/12014951 DMDGWAY DI DMDGWAY DMDGWAY DN 1-Cyclopentylidenethiosemicarbazide DMDGWAY MI TTULVH8 DMDGWAY MN Tyrosinase (TYR) DMDGWAY MT DTT DMDGWAY MA Inhibitor DMDGWAY RN A class of potent tyrosinase inhibitors: alkylidenethiosemicarbazide compounds. Eur J Med Chem. 2009 Apr;44(4):1773-8. DMDGWAY RU https://pubmed.ncbi.nlm.nih.gov/18524420 DMGSQTK DI DMGSQTK DMGSQTK DN 1D05 DMGSQTK MI TTBRG7E DMGSQTK MN Proprotein convertase subtilisin/kexin type 9 (PCSK9) DMGSQTK MT DTT DMGSQTK RN A PCSK9-binding antibody that structurally mimics the EGF(A) domain of LDL-receptor reduces LDL cholesterol in vivo. J Lipid Res. 2011 Jan;52(1):78-86. DMGSQTK RU https://pubmed.ncbi.nlm.nih.gov/20959675 DMG0VN6 DI DMG0VN6 DMG0VN6 DN 1-Deaza-Adenosine DMG0VN6 MI TTLP57V DMG0VN6 MN Adenosine deaminase (ADA) DMG0VN6 MT DTT DMG0VN6 MA Inhibitor DMG0VN6 RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMG0VN6 RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMOEQDP DI DMOEQDP DMOEQDP DN 1-Deoxy-1-Methoxycarbamido-Beta-D-Glucopyranose DMOEQDP MI TTZHY6R DMOEQDP MN Glycogen phosphorylase muscle form (GP) DMOEQDP MT DTT DMOEQDP MA Inhibitor DMOEQDP RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMOEQDP RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMAEWHB DI DMAEWHB DMAEWHB DN 1-Deoxy-1-Thio-Heptaethylene Glycol DMAEWHB MI TT1RS9F DMAEWHB MN Acetylcholinesterase (AChE) DMAEWHB MT DTT DMAEWHB MA Inhibitor DMAEWHB RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DMAEWHB RU https://pubmed.ncbi.nlm.nih.gov/10592235 DMCSPU4 DI DMCSPU4 DMCSPU4 DN 1-Deoxy-D-Xylulose-5-Phosphate DMCSPU4 MI TTHB48R DMCSPU4 MN Bacterial Pyridoxal phosphate biosynthetic pdxJ (Bact pdxJ) DMCSPU4 MT DTT DMCSPU4 MA Inhibitor DMCSPU4 RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMCSPU4 RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMH9WFD DI DMH9WFD DMH9WFD DN 1-Deoxy-Ribofuranose-5'-Phosphate DMH9WFD MI TTVNA43 DMH9WFD MN Bacterial Deoxy-D-manno-octulosonate 8-phosphate synthase (Bact kdsA) DMH9WFD MT DTT DMH9WFD MA Inhibitor DMH9WFD RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMH9WFD RU https://pubmed.ncbi.nlm.nih.gov/17139284 DM4NBUH DI DM4NBUH DM4NBUH DN 1-D-glucopyranosyl cytosine DM4NBUH MI TTZHY6R DM4NBUH MN Glycogen phosphorylase muscle form (GP) DM4NBUH MT DTT DM4NBUH MA Inhibitor DM4NBUH RN 1-(3-Deoxy-3-fluoro-beta-d-glucopyranosyl) pyrimidine derivatives as inhibitors of glycogen phosphorylase b: Kinetic, crystallographic and modellin... Bioorg Med Chem. 2010 May 15;18(10):3413-25. DM4NBUH RU https://pubmed.ncbi.nlm.nih.gov/20430629 DM90ULM DI DM90ULM DM90ULM DN 1-D-glucopyranosyl uracil DM90ULM MI TTZHY6R DM90ULM MN Glycogen phosphorylase muscle form (GP) DM90ULM MT DTT DM90ULM MA Inhibitor DM90ULM RN 1-(3-Deoxy-3-fluoro-beta-d-glucopyranosyl) pyrimidine derivatives as inhibitors of glycogen phosphorylase b: Kinetic, crystallographic and modellin... Bioorg Med Chem. 2010 May 15;18(10):3413-25. DM90ULM RU https://pubmed.ncbi.nlm.nih.gov/20430629 DMOL2Y0 DI DMOL2Y0 DMOL2Y0 DN 1-Dibenzo[b,f]oxepin-10-yl-4-methyl-piperazine DMOL2Y0 MI TTZFYLI DMOL2Y0 MN Dopamine D1 receptor (D1R) DMOL2Y0 MT DTT DMOL2Y0 MA Inhibitor DMOL2Y0 RN Affinity of 10-(4-methylpiperazino)dibenz[b,f]oxepins for clozapine and spiroperidol binding sites in rat brain. J Med Chem. 1982 Jul;25(7):855-8. DMOL2Y0 RU https://pubmed.ncbi.nlm.nih.gov/7108902 DMOL2Y0 DI DMOL2Y0 DMOL2Y0 DN 1-Dibenzo[b,f]oxepin-10-yl-4-methyl-piperazine DMOL2Y0 MI TTEX248 DMOL2Y0 MN Dopamine D2 receptor (D2R) DMOL2Y0 MT DTT DMOL2Y0 MA Inhibitor DMOL2Y0 RN Affinity of 10-(4-methylpiperazino)dibenz[b,f]oxepins for clozapine and spiroperidol binding sites in rat brain. J Med Chem. 1982 Jul;25(7):855-8. DMOL2Y0 RU https://pubmed.ncbi.nlm.nih.gov/7108902 DMOL2Y0 DI DMOL2Y0 DMOL2Y0 DN 1-Dibenzo[b,f]oxepin-10-yl-4-methyl-piperazine DMOL2Y0 MI TT4C8EA DMOL2Y0 MN Dopamine D3 receptor (D3R) DMOL2Y0 MT DTT DMOL2Y0 MA Inhibitor DMOL2Y0 RN Affinity of 10-(4-methylpiperazino)dibenz[b,f]oxepins for clozapine and spiroperidol binding sites in rat brain. J Med Chem. 1982 Jul;25(7):855-8. DMOL2Y0 RU https://pubmed.ncbi.nlm.nih.gov/7108902 DMOL2Y0 DI DMOL2Y0 DMOL2Y0 DN 1-Dibenzo[b,f]oxepin-10-yl-4-methyl-piperazine DMOL2Y0 MI TTE0A2F DMOL2Y0 MN Dopamine D4 receptor (D4R) DMOL2Y0 MT DTT DMOL2Y0 MA Inhibitor DMOL2Y0 RN Affinity of 10-(4-methylpiperazino)dibenz[b,f]oxepins for clozapine and spiroperidol binding sites in rat brain. J Med Chem. 1982 Jul;25(7):855-8. DMOL2Y0 RU https://pubmed.ncbi.nlm.nih.gov/7108902 DMOL2Y0 DI DMOL2Y0 DMOL2Y0 DN 1-Dibenzo[b,f]oxepin-10-yl-4-methyl-piperazine DMOL2Y0 MI TTS2PH3 DMOL2Y0 MN Dopamine D5 receptor (D5R) DMOL2Y0 MT DTT DMOL2Y0 MA Inhibitor DMOL2Y0 RN Affinity of 10-(4-methylpiperazino)dibenz[b,f]oxepins for clozapine and spiroperidol binding sites in rat brain. J Med Chem. 1982 Jul;25(7):855-8. DMOL2Y0 RU https://pubmed.ncbi.nlm.nih.gov/7108902 DMOSRET DI DMOSRET DMOSRET DN 1DMe DMOSRET MI TTEP027 DMOSRET MN Neuropeptide FF receptor 1 (NPFFR1) DMOSRET MT DTT DMOSRET MA Agonist DMOSRET RN Quantitative autoradiographic distribution of NPFF1 neuropeptide FF receptor in the rat brain and comparison with NPFF2 receptor by using [125I]YVP and [(125I]EYF as selective radioligands. Neuroscience. 2002;115(2):349-61. DMOSRET RU https://pubmed.ncbi.nlm.nih.gov/12421602 DMOSRET DI DMOSRET DMOSRET DN 1DMe DMOSRET MI TTXYNDJ DMOSRET MN Neuropeptide FF receptor 2 (NPFFR2) DMOSRET MT DTT DMOSRET MA Agonist DMOSRET RN Quantitative autoradiographic distribution of NPFF1 neuropeptide FF receptor in the rat brain and comparison with NPFF2 receptor by using [125I]YVP and [(125I]EYF as selective radioligands. Neuroscience. 2002;115(2):349-61. DMOSRET RU https://pubmed.ncbi.nlm.nih.gov/12421602 DM7P3N5 DI DM7P3N5 DM7P3N5 DN 1-DODECANOL DM7P3N5 MI TTDP1UC DM7P3N5 MN Fatty acid amide hydrolase (FAAH) DM7P3N5 MT DTT DM7P3N5 MA Inhibitor DM7P3N5 RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DM7P3N5 RU https://pubmed.ncbi.nlm.nih.gov/10592235 DMK6BWV DI DMK6BWV DMK6BWV DN 1-dodecyl-1H-indole-2,3-dione DMK6BWV MI TTMF541 DMK6BWV MN Liver carboxylesterase (CES1) DMK6BWV MT DTT DMK6BWV MA Inhibitor DMK6BWV RN Selective inhibition of carboxylesterases by isatins, indole-2,3-diones. J Med Chem. 2007 Apr 19;50(8):1876-85. DMK6BWV RU https://pubmed.ncbi.nlm.nih.gov/17378546 DMK6BWV DI DMK6BWV DMK6BWV DN 1-dodecyl-1H-indole-2,3-dione DMK6BWV MI TTLZS4Q DMK6BWV MN M-phase inducer phosphatase 1 (MPIP1) DMK6BWV MT DTT DMK6BWV MA Inhibitor DMK6BWV RN Design and synthesis of N-alkyl oxindolylidene acetic acids as a new class of potent Cdc25A inhibitors. Bioorg Med Chem Lett. 2008 Jun 1;18(11):3350-3. DMK6BWV RU https://pubmed.ncbi.nlm.nih.gov/18442908 DMJBFN0 DI DMJBFN0 DMJBFN0 DN 1-ETHOXY-2-(2-ETHOXYETHOXY)ETHANE DMJBFN0 MI TT1RS9F DMJBFN0 MN Acetylcholinesterase (AChE) DMJBFN0 MT DTT DMJBFN0 MA Inhibitor DMJBFN0 RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DMJBFN0 RU https://pubmed.ncbi.nlm.nih.gov/10592235 DMJBFN0 DI DMJBFN0 DMJBFN0 DN 1-ETHOXY-2-(2-ETHOXYETHOXY)ETHANE DMJBFN0 MI TTFGVKC DMJBFN0 MN Bacterial Phosphoenolpyruvate transferase (Bact ptsI) DMJBFN0 MT DTT DMJBFN0 MA Inhibitor DMJBFN0 RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DMJBFN0 RU https://pubmed.ncbi.nlm.nih.gov/10592235 DM5UWH9 DI DM5UWH9 DM5UWH9 DN 1-Ethyl-3-imidazol-1-ylmethyl-1H-indole DM5UWH9 MI TTIQUX7 DM5UWH9 MN Steroid 11-beta-hydroxylase (CYP11B1) DM5UWH9 MT DTT DM5UWH9 MA Inhibitor DM5UWH9 RN Selective thromboxane synthetase inhibitors. 2. 3-(1H-imidazol-1-ylmethyl)-2-methyl-1H-indole-1-propanoic acid and analogues. J Med Chem. 1986 Mar;29(3):342-6. DM5UWH9 RU https://pubmed.ncbi.nlm.nih.gov/3081722 DMSFINY DI DMSFINY DMSFINY DN 1-Ethyl-3-methyl-3,7-dihydro-purine-2,6-dione DMSFINY MI TTM2AOE DMSFINY MN Adenosine A2a receptor (ADORA2A) DMSFINY MT DTT DMSFINY MA Inhibitor DMSFINY RN Analogues of caffeine and theophylline: effect of structural alterations on affinity at adenosine receptors. J Med Chem. 1986 Jul;29(7):1305-8. DMSFINY RU https://pubmed.ncbi.nlm.nih.gov/3806581 DMGKP9Y DI DMGKP9Y DMGKP9Y DN 1-Ethyl-4-(2-methoxy-phenyl)-piperazine DMGKP9Y MI TTSQIFT DMGKP9Y MN 5-HT 1A receptor (HTR1A) DMGKP9Y MT DTT DMGKP9Y MA Inhibitor DMGKP9Y RN Structure-activity relationship studies of central nervous system agents. 13. 4-[3-(Benzotriazol-1-yl)propyl]-1-(2-methoxyphenyl)piperazine, a new ... J Med Chem. 1994 Aug 19;37(17):2754-60. DMGKP9Y RU https://pubmed.ncbi.nlm.nih.gov/8064802 DMGKP9Y DI DMGKP9Y DMGKP9Y DN 1-Ethyl-4-(2-methoxy-phenyl)-piperazine DMGKP9Y MI TTJQOD7 DMGKP9Y MN 5-HT 2A receptor (HTR2A) DMGKP9Y MT DTT DMGKP9Y MA Inhibitor DMGKP9Y RN Structure-activity relationship studies of central nervous system agents. 13. 4-[3-(Benzotriazol-1-yl)propyl]-1-(2-methoxyphenyl)piperazine, a new ... J Med Chem. 1994 Aug 19;37(17):2754-60. DMGKP9Y RU https://pubmed.ncbi.nlm.nih.gov/8064802 DMUOSJG DI DMUOSJG DMUOSJG DN 1-Ethyl-5-(imidazol-1-yl-phenyl-methyl)-1H-indole DMUOSJG MI TTSZLWK DMUOSJG MN Aromatase (CYP19A1) DMUOSJG MT DTT DMUOSJG MA Inhibitor DMUOSJG RN New selective nonsteroidal aromatase inhibitors: synthesis and inhibitory activity of 2,3 or 5-(alpha-azolylbenzyl)-1H-indoles. Bioorg Med Chem Lett. 1999 Feb 8;9(3):333-6. DMUOSJG RU https://pubmed.ncbi.nlm.nih.gov/10091679 DMUOSJG DI DMUOSJG DMUOSJG DN 1-Ethyl-5-(imidazol-1-yl-phenyl-methyl)-1H-indole DMUOSJG MI TTRA5BZ DMUOSJG MN Steroid 17-alpha-monooxygenase (S17AH) DMUOSJG MT DTT DMUOSJG MA Inhibitor DMUOSJG RN New selective nonsteroidal aromatase inhibitors: synthesis and inhibitory activity of 2,3 or 5-(alpha-azolylbenzyl)-1H-indoles. Bioorg Med Chem Lett. 1999 Feb 8;9(3):333-6. DMUOSJG RU https://pubmed.ncbi.nlm.nih.gov/10091679 DMQRKZO DI DMQRKZO DMQRKZO DN 1-Ethylidenethiosemicarbazide DMQRKZO MI TTULVH8 DMQRKZO MN Tyrosinase (TYR) DMQRKZO MT DTT DMQRKZO MA Inhibitor DMQRKZO RN A class of potent tyrosinase inhibitors: alkylidenethiosemicarbazide compounds. Eur J Med Chem. 2009 Apr;44(4):1773-8. DMQRKZO RU https://pubmed.ncbi.nlm.nih.gov/18524420 DM0Q46C DI DM0Q46C DM0Q46C DN 1-fluoro-5-phenyl-3-aza-bicyclo[3.1.0]hexane DM0Q46C MI TT3ROYC DM0Q46C MN Serotonin transporter (SERT) DM0Q46C MT DTT DM0Q46C MA Inhibitor DM0Q46C RN Studies on the structure-activity relationship of bicifadine analogs as monoamine transporter inhibitors. Bioorg Med Chem Lett. 2008 Jul 1;18(13):3682-6. DM0Q46C RU https://pubmed.ncbi.nlm.nih.gov/18539031 DM8BC1M DI DM8BC1M DM8BC1M DN 1-Fluoro-6-(4-hydroxy-phenyl)-naphthalen-2-ol DM8BC1M MI TTZAYWL DM8BC1M MN Estrogen receptor (ESR) DM8BC1M MT DTT DM8BC1M MA Inhibitor DM8BC1M RN ERbeta ligands. 3. Exploiting two binding orientations of the 2-phenylnaphthalene scaffold to achieve ERbeta selectivity. J Med Chem. 2005 Jun 16;48(12):3953-79. DM8BC1M RU https://pubmed.ncbi.nlm.nih.gov/15943471 DM8BC1M DI DM8BC1M DM8BC1M DN 1-Fluoro-6-(4-hydroxy-phenyl)-naphthalen-2-ol DM8BC1M MI TTOM3J0 DM8BC1M MN Estrogen receptor beta (ESR2) DM8BC1M MT DTT DM8BC1M MA Inhibitor DM8BC1M RN ERbeta ligands. 3. Exploiting two binding orientations of the 2-phenylnaphthalene scaffold to achieve ERbeta selectivity. J Med Chem. 2005 Jun 16;48(12):3953-79. DM8BC1M RU https://pubmed.ncbi.nlm.nih.gov/15943471 DM7UK56 DI DM7UK56 DM7UK56 DN 1-furan-2-yl-3-pyridin-2-yl-propenone (FPP-3) DM7UK56 MI TT2J34L DM7UK56 MN Arachidonate 5-lipoxygenase (5-LOX) DM7UK56 MT DTT DM7UK56 MA Inhibitor DM7UK56 RN The anti-angiogenic effects of 1-furan-2-yl-3-pyridin-2-yl-propenone are mediated through the suppression of both VEGF production and VEGF-induced ... Vascul Pharmacol. 2009 Mar-Apr;50(3-4):123-31. DM7UK56 RU https://pubmed.ncbi.nlm.nih.gov/19068239 DMF4BCP DI DMF4BCP DMF4BCP DN 1-Furan-2-ylmethyl-3-thiazol-2-yl-thiourea DMF4BCP MI TT84ETX DMF4BCP MN Human immunodeficiency virus Reverse transcriptase (HIV RT) DMF4BCP MT DTT DMF4BCP MA Inhibitor DMF4BCP RN Anti-HIV activity of aromatic and heterocyclic thiazolyl thiourea compounds. Bioorg Med Chem Lett. 2001 Feb 26;11(4):523-8. DMF4BCP RU https://pubmed.ncbi.nlm.nih.gov/11229762 DMEB8CG DI DMEB8CG DMEB8CG DN 1G244 DMEB8CG MI TTJGLZF DMEB8CG MN Dipeptidyl peptidase 8 (DPP-8) DMEB8CG MT DTT DMEB8CG MA Inhibitor DMEB8CG RN Biochemistry, pharmacokinetics, and toxicology of a potent and selective DPP8/9 inhibitor. Biochem Pharmacol. 2009 Jul 15;78(2):203-10. DMEB8CG RU https://pubmed.ncbi.nlm.nih.gov/19439267 DMEB8CG DI DMEB8CG DMEB8CG DN 1G244 DMEB8CG MI TTNDUL7 DMEB8CG MN Dipeptidyl peptidase 9 (DPP-9) DMEB8CG MT DTT DMEB8CG MA Inhibitor DMEB8CG RN Biochemistry, pharmacokinetics, and toxicology of a potent and selective DPP8/9 inhibitor. Biochem Pharmacol. 2009 Jul 15;78(2):203-10. DMEB8CG RU https://pubmed.ncbi.nlm.nih.gov/19439267 DM42IY7 DI DM42IY7 DM42IY7 DN 1-Guanidinium-7-Aminoheptane DM42IY7 MI TTBO2A9 DM42IY7 MN Deoxyhypusine synthase (DHPS) DM42IY7 MT DTT DM42IY7 MA Inhibitor DM42IY7 RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DM42IY7 RU https://pubmed.ncbi.nlm.nih.gov/17139284 DM48TIN DI DM48TIN DM48TIN DN 1-guanidino-7-isoquinolinesulphonamide DM48TIN MI TTP86E2 DM48TIN MN Plasminogen (PLG) DM48TIN MT DTT DM48TIN MA Inhibitor DM48TIN RN Selective urokinase-type plasminogen activator inhibitors. 4. 1-(7-sulfonamidoisoquinolinyl)guanidines. J Med Chem. 2007 May 17;50(10):2341-51. DM48TIN RU https://pubmed.ncbi.nlm.nih.gov/17447747 DM48TIN DI DM48TIN DM48TIN DN 1-guanidino-7-isoquinolinesulphonamide DM48TIN MI TTGY7WI DM48TIN MN Urokinase-type plasminogen activator (PLAU) DM48TIN MT DTT DM48TIN MA Inhibitor DM48TIN RN Selective urokinase-type plasminogen activator inhibitors. 4. 1-(7-sulfonamidoisoquinolinyl)guanidines. J Med Chem. 2007 May 17;50(10):2341-51. DM48TIN RU https://pubmed.ncbi.nlm.nih.gov/17447747 DMTF1HL DI DMTF1HL DMTF1HL DN 1-guanidino-N-phenyl-7-isoquinolinesulphonamide DMTF1HL MI TTP86E2 DMTF1HL MN Plasminogen (PLG) DMTF1HL MT DTT DMTF1HL MA Inhibitor DMTF1HL RN Selective urokinase-type plasminogen activator inhibitors. 4. 1-(7-sulfonamidoisoquinolinyl)guanidines. J Med Chem. 2007 May 17;50(10):2341-51. DMTF1HL RU https://pubmed.ncbi.nlm.nih.gov/17447747 DMTF1HL DI DMTF1HL DMTF1HL DN 1-guanidino-N-phenyl-7-isoquinolinesulphonamide DMTF1HL MI TTXAGYU DMTF1HL MN Tissue-type plasminogen activator (PLAT) DMTF1HL MT DTT DMTF1HL MA Inhibitor DMTF1HL RN Selective urokinase-type plasminogen activator inhibitors. 4. 1-(7-sulfonamidoisoquinolinyl)guanidines. J Med Chem. 2007 May 17;50(10):2341-51. DMTF1HL RU https://pubmed.ncbi.nlm.nih.gov/17447747 DMTF1HL DI DMTF1HL DMTF1HL DN 1-guanidino-N-phenyl-7-isoquinolinesulphonamide DMTF1HL MI TTGY7WI DMTF1HL MN Urokinase-type plasminogen activator (PLAU) DMTF1HL MT DTT DMTF1HL MA Inhibitor DMTF1HL RN Selective urokinase-type plasminogen activator inhibitors. 4. 1-(7-sulfonamidoisoquinolinyl)guanidines. J Med Chem. 2007 May 17;50(10):2341-51. DMTF1HL RU https://pubmed.ncbi.nlm.nih.gov/17447747 DM9KAI5 DI DM9KAI5 DM9KAI5 DN 1H-1,2,3-benzotriazol-1-amine DM9KAI5 MI TTXV4FI DM9KAI5 MN Albendazole monooxygenase (CYP3A4) DM9KAI5 MT DTT DM9KAI5 MA Inhibitor DM9KAI5 RN Discovery of a N'-hydroxyphenylformamidine derivative HET0016 as a potent and selective 20-HETE synthase inhibitor. Bioorg Med Chem Lett. 2001 Dec 3;11(23):2993-5. DM9KAI5 RU https://pubmed.ncbi.nlm.nih.gov/11714595 DM9KAI5 DI DM9KAI5 DM9KAI5 DN 1H-1,2,3-benzotriazol-1-amine DM9KAI5 MI TTVG215 DM9KAI5 MN Debrisoquine 4-hydroxylase (CYP2D6) DM9KAI5 MT DTT DM9KAI5 MA Inhibitor DM9KAI5 RN Discovery of a N'-hydroxyphenylformamidine derivative HET0016 as a potent and selective 20-HETE synthase inhibitor. Bioorg Med Chem Lett. 2001 Dec 3;11(23):2993-5. DM9KAI5 RU https://pubmed.ncbi.nlm.nih.gov/11714595 DMNZAVE DI DMNZAVE DMNZAVE DN 1h-Benoximidazole-2-Carboxylic Acid DMNZAVE MI TTPT2QI DMNZAVE MN Cathepsin D (CTSD) DMNZAVE MT DTT DMNZAVE MA Inhibitor DMNZAVE RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMNZAVE RU https://pubmed.ncbi.nlm.nih.gov/17139284 DM4OWM6 DI DM4OWM6 DM4OWM6 DN 1-hexadecyl-1H-indole-2,3-dione DM4OWM6 MI TTMF541 DM4OWM6 MN Liver carboxylesterase (CES1) DM4OWM6 MT DTT DM4OWM6 MA Inhibitor DM4OWM6 RN Selective inhibition of carboxylesterases by isatins, indole-2,3-diones. J Med Chem. 2007 Apr 19;50(8):1876-85. DM4OWM6 RU https://pubmed.ncbi.nlm.nih.gov/17378546 DMME09C DI DMME09C DMME09C DN 1H-Imidazo[4,5-c]quinolin-4-ylamine HCl DMME09C MI TTK25J1 DMME09C MN Adenosine A1 receptor (ADORA1) DMME09C MT DTT DMME09C MA Inhibitor DMME09C RN 1H-imidazo[4,5-c]quinolin-4-amines: novel non-xanthine adenosine antagonists. J Med Chem. 1991 Mar;34(3):1202-6. DMME09C RU https://pubmed.ncbi.nlm.nih.gov/2002461 DMME09C DI DMME09C DMME09C DN 1H-Imidazo[4,5-c]quinolin-4-ylamine HCl DMME09C MI TTM2AOE DMME09C MN Adenosine A2a receptor (ADORA2A) DMME09C MT DTT DMME09C MA Inhibitor DMME09C RN 1H-imidazo[4,5-c]quinolin-4-amines: novel non-xanthine adenosine antagonists. J Med Chem. 1991 Mar;34(3):1202-6. DMME09C RU https://pubmed.ncbi.nlm.nih.gov/2002461 DMME09C DI DMME09C DMME09C DN 1H-Imidazo[4,5-c]quinolin-4-ylamine HCl DMME09C MI TTNE7KG DMME09C MN Adenosine A2b receptor (ADORA2B) DMME09C MT DTT DMME09C MA Inhibitor DMME09C RN 1H-imidazo[4,5-c]quinolin-4-amines: novel non-xanthine adenosine antagonists. J Med Chem. 1991 Mar;34(3):1202-6. DMME09C RU https://pubmed.ncbi.nlm.nih.gov/2002461 DMOZ91H DI DMOZ91H DMOZ91H DN 1H-Indole-2,3-dione DMOZ91H MI TTGP7BY DMOZ91H MN Monoamine oxidase type B (MAO-B) DMOZ91H MT DTT DMOZ91H MA Inhibitor DMOZ91H RN DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Nucleic Acids Res. 2011 Jan;39(Database issue):D1035-41. DMOZ91H RU https://pubmed.ncbi.nlm.nih.gov/21059682 DMOZ91H DI DMOZ91H DMOZ91H DN 1H-Indole-2,3-dione DMOZ91H MI DEIVKZ8 DMOZ91H MN NADPH-dependent carbonyl reductase 3 (CBR3) DMOZ91H MT DME DMOZ91H MA Metabolism DMOZ91H RN Analysis of the substrate-binding site of human carbonyl reductases CBR1 and CBR3 by site-directed mutagenesis. Chem Biol Interact. 2009 Mar 16;178(1-3):234-41. DMOZ91H RU https://www.ncbi.nlm.nih.gov/pubmed/?term=19061875 DMNDVMH DI DMNDVMH DMNDVMH DN 1H-indole-4,7-dione DMNDVMH MI TTZJYKH DMNDVMH MN Indoleamine 2,3-dioxygenase 1 (IDO1) DMNDVMH MT DTT DMNDVMH MA Inhibitor DMNDVMH RN Synthesis of indoleamine 2,3-dioxygenase inhibitory analogues of the sponge alkaloid exiguamine A. J Med Chem. 2008 May 8;51(9):2634-7. DMNDVMH RU https://pubmed.ncbi.nlm.nih.gov/18393489 DM4V6JE DI DM4V6JE DM4V6JE DN 1H-Pyrazole-3-carboxylic acid DM4V6JE MI TTWNV8U DM4V6JE MN Nicotinic acid receptor (HCAR2) DM4V6JE MT DTT DM4V6JE MA Inhibitor DM4V6JE RN Pyrazole derivatives as partial agonists for the nicotinic acid receptor. J Med Chem. 2003 Aug 28;46(18):3945-51. DM4V6JE RU https://pubmed.ncbi.nlm.nih.gov/12930155 DM235CQ DI DM235CQ DM235CQ DN 1-Hydroxy-10H-anthracen-9-one DM235CQ MI TT2J34L DM235CQ MN Arachidonate 5-lipoxygenase (5-LOX) DM235CQ MT DTT DM235CQ MA Inhibitor DM235CQ RN Simple analogues of anthralin: unusual specificity of structure and antiproliferative activity. J Med Chem. 1997 Nov 7;40(23):3773-80. DM235CQ RU https://pubmed.ncbi.nlm.nih.gov/9371243 DMIOTQ8 DI DMIOTQ8 DMIOTQ8 DN 1-Hydroxy-1-Thio-Glycerol DMIOTQ8 MI TTNGKET DMIOTQ8 MN Prolyl endopeptidase (PREP) DMIOTQ8 MT DTT DMIOTQ8 MA Inhibitor DMIOTQ8 RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMIOTQ8 RU https://pubmed.ncbi.nlm.nih.gov/17139284 DM9EWN8 DI DM9EWN8 DM9EWN8 DN 1-Hydroxy-2-Amino-3-Cyclohexylpropane DM9EWN8 MI TTB2MXP DM9EWN8 MN Angiotensinogenase renin (REN) DM9EWN8 MT DTT DM9EWN8 MA Inhibitor DM9EWN8 RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DM9EWN8 RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMGBSWP DI DMGBSWP DMGBSWP DN 1-hydroxy-2-dodecyl-4(1H)quinolone DMGBSWP MI TT3PQ2Y DMGBSWP MN Plasmodium Dihydroorotate dehydrogenase (Malaria DHOdehase) DMGBSWP MT DTT DMGBSWP MA Inhibitor DMGBSWP RN Type II NADH dehydrogenase of the respiratory chain of Plasmodium falciparum and its inhibitors. Bioorg Med Chem Lett. 2009 Feb 1;19(3):972-5. DMGBSWP RU https://pubmed.ncbi.nlm.nih.gov/19097788 DMGNVEF DI DMGNVEF DMGNVEF DN 1-hydroxy-3-(4-(trifluoromethyl)phenyl)urea DMGNVEF MI TTULVH8 DMGNVEF MN Tyrosinase (TYR) DMGNVEF MT DTT DMGNVEF MA Inhibitor DMGNVEF RN Analogues of N-hydroxy-N'-phenylthiourea and N-hydroxy-N'-phenylurea as inhibitors of tyrosinase and melanin formation. Bioorg Med Chem Lett. 2008 Jun 15;18(12):3607-10. DMGNVEF RU https://pubmed.ncbi.nlm.nih.gov/18501598 DMZ7GUP DI DMZ7GUP DMZ7GUP DN 1-hydroxy-3-(4-nitrophenyl)urea DMZ7GUP MI TTULVH8 DMZ7GUP MN Tyrosinase (TYR) DMZ7GUP MT DTT DMZ7GUP MA Inhibitor DMZ7GUP RN Analogues of N-hydroxy-N'-phenylthiourea and N-hydroxy-N'-phenylurea as inhibitors of tyrosinase and melanin formation. Bioorg Med Chem Lett. 2008 Jun 15;18(12):3607-10. DMZ7GUP RU https://pubmed.ncbi.nlm.nih.gov/18501598 DMZ8IL9 DI DMZ8IL9 DMZ8IL9 DN 1-Hydroxy-3-Methylbutane DMZ8IL9 MI TTB2MXP DMZ8IL9 MN Angiotensinogenase renin (REN) DMZ8IL9 MT DTT DMZ8IL9 MA Inhibitor DMZ8IL9 RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMZ8IL9 RU https://pubmed.ncbi.nlm.nih.gov/17139284 DM4TSVC DI DM4TSVC DM4TSVC DN 1-hydroxy-3-phenylurea DM4TSVC MI TTULVH8 DM4TSVC MN Tyrosinase (TYR) DM4TSVC MT DTT DM4TSVC MA Inhibitor DM4TSVC RN Analogues of N-hydroxy-N'-phenylthiourea and N-hydroxy-N'-phenylurea as inhibitors of tyrosinase and melanin formation. Bioorg Med Chem Lett. 2008 Jun 15;18(12):3607-10. DM4TSVC RU https://pubmed.ncbi.nlm.nih.gov/18501598 DMRNO5U DI DMRNO5U DMRNO5U DN 1-Hydroxy-8-methoxy-10H-anthracen-9-one DMRNO5U MI TT2J34L DMRNO5U MN Arachidonate 5-lipoxygenase (5-LOX) DMRNO5U MT DTT DMRNO5U MA Inhibitor DMRNO5U RN Simple analogues of anthralin: unusual specificity of structure and antiproliferative activity. J Med Chem. 1997 Nov 7;40(23):3773-80. DMRNO5U RU https://pubmed.ncbi.nlm.nih.gov/9371243 DM6FLXW DI DM6FLXW DM6FLXW DN 1-Hydroxyamine-2-Isobutylmalonic Acid DM6FLXW MI TTGA1IV DM6FLXW MN Matrix metalloproteinase-8 (MMP-8) DM6FLXW MT DTT DM6FLXW MA Inhibitor DM6FLXW RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DM6FLXW RU https://pubmed.ncbi.nlm.nih.gov/17139284 DM3JHVL DI DM3JHVL DM3JHVL DN 1-Imidazol-1-yl-3-(4-octylphenoxy)propan-2-one DM3JHVL MI TTT1JVS DM3JHVL MN Cytosolic phospholipase A2 (GIVA cPLA2) DM3JHVL MT DTT DM3JHVL MA Inhibitor DM3JHVL RN 1-Indol-1-yl-propan-2-ones and related heterocyclic compounds as dual inhibitors of cytosolic phospholipase A(2)alpha and fatty acid amide hydrolase. Bioorg Med Chem. 2010 Jan 15;18(2):945-52. DM3JHVL RU https://pubmed.ncbi.nlm.nih.gov/20005725 DM3JHVL DI DM3JHVL DM3JHVL DN 1-Imidazol-1-yl-3-(4-octylphenoxy)propan-2-one DM3JHVL MI TTDP1UC DM3JHVL MN Fatty acid amide hydrolase (FAAH) DM3JHVL MT DTT DM3JHVL MA Inhibitor DM3JHVL RN 1-Indol-1-yl-propan-2-ones and related heterocyclic compounds as dual inhibitors of cytosolic phospholipase A(2)alpha and fatty acid amide hydrolase. Bioorg Med Chem. 2010 Jan 15;18(2):945-52. DM3JHVL RU https://pubmed.ncbi.nlm.nih.gov/20005725 DMN7KHS DI DMN7KHS DMN7KHS DN 1-Imidazol-1-ylmethyl-4-nitro-xanthen-9-one DMN7KHS MI TTSZLWK DMN7KHS MN Aromatase (CYP19A1) DMN7KHS MT DTT DMN7KHS MA Inhibitor DMN7KHS RN A new class of nonsteroidal aromatase inhibitors: design and synthesis of chromone and xanthone derivatives and inhibition of the P450 enzymes aromatase and 17 alpha-hydroxylase/C17,20-lyase. J Med Chem. 2001 Mar 1;44(5):672-80. DMN7KHS RU https://pubmed.ncbi.nlm.nih.gov/11262078 DMN7KHS DI DMN7KHS DMN7KHS DN 1-Imidazol-1-ylmethyl-4-nitro-xanthen-9-one DMN7KHS MI TTRA5BZ DMN7KHS MN Steroid 17-alpha-monooxygenase (S17AH) DMN7KHS MT DTT DMN7KHS MA Inhibitor DMN7KHS RN A new class of nonsteroidal aromatase inhibitors: design and synthesis of chromone and xanthone derivatives and inhibition of the P450 enzymes aromatase and 17 alpha-hydroxylase/C17,20-lyase. J Med Chem. 2001 Mar 1;44(5):672-80. DMN7KHS RU https://pubmed.ncbi.nlm.nih.gov/11262078 DMIDX7P DI DMIDX7P DMIDX7P DN 1-Imidazol-1-ylmethylxanthen-9-one DMIDX7P MI TTSZLWK DMIDX7P MN Aromatase (CYP19A1) DMIDX7P MT DTT DMIDX7P MA Inhibitor DMIDX7P RN Novel highly potent and selective nonsteroidal aromatase inhibitors: synthesis, biological evaluation and structure-activity relationships investigation. J Med Chem. 2010 Jul 22;53(14):5347-51. DMIDX7P RU https://pubmed.ncbi.nlm.nih.gov/20568782 DMIDX7P DI DMIDX7P DMIDX7P DN 1-Imidazol-1-ylmethylxanthen-9-one DMIDX7P MI TTRA5BZ DMIDX7P MN Steroid 17-alpha-monooxygenase (S17AH) DMIDX7P MT DTT DMIDX7P MA Inhibitor DMIDX7P RN Novel highly potent and selective nonsteroidal aromatase inhibitors: synthesis, biological evaluation and structure-activity relationships investigation. J Med Chem. 2010 Jul 22;53(14):5347-51. DMIDX7P RU https://pubmed.ncbi.nlm.nih.gov/20568782 DMYIQDE DI DMYIQDE DMYIQDE DN 1-Iodyl-3-nitro-benzene DMYIQDE MI TTELIN2 DMYIQDE MN PTPN1 messenger RNA (PTPN1 mRNA) DMYIQDE MT DTT DMYIQDE MA Inhibitor DMYIQDE RN Periodinates: a new class of protein tyrosine phosphatase inhibitors. Bioorg Med Chem Lett. 1999 Feb 8;9(3):353-6. DMYIQDE RU https://pubmed.ncbi.nlm.nih.gov/10091683 DMF1WA6 DI DMF1WA6 DMF1WA6 DN 1-Iodyl-4-nitro-benzene DMF1WA6 MI TTELIN2 DMF1WA6 MN PTPN1 messenger RNA (PTPN1 mRNA) DMF1WA6 MT DTT DMF1WA6 MA Inhibitor DMF1WA6 RN Periodinates: a new class of protein tyrosine phosphatase inhibitors. Bioorg Med Chem Lett. 1999 Feb 8;9(3):353-6. DMF1WA6 RU https://pubmed.ncbi.nlm.nih.gov/10091683 DMD7WNV DI DMD7WNV DMD7WNV DN 1-Methoxy-2-[2-(2-Methoxy-Ethoxy]-Ethane DMD7WNV MI TT2B9KF DMD7WNV MN Fyn tyrosine protein kinase (FYN) DMD7WNV MT DTT DMD7WNV MA Inhibitor DMD7WNV RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMD7WNV RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMD7WNV DI DMD7WNV DMD7WNV DN 1-Methoxy-2-[2-(2-Methoxy-Ethoxy]-Ethane DMD7WNV MI TT04R7I DMD7WNV MN Transketolase (TK) DMD7WNV MT DTT DMD7WNV MA Inhibitor DMD7WNV RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMD7WNV RU https://pubmed.ncbi.nlm.nih.gov/17139284 DM7DTRM DI DM7DTRM DM7DTRM DN 1-methoxy-3-(3-(pyridin-4-yl)-1H-indol-6-yl)urea DM7DTRM MI TTTB4UP DM7DTRM MN Inosine-5'-monophosphate dehydrogenase 2 (IMPDH2) DM7DTRM MT DTT DM7DTRM MA Inhibitor DM7DTRM RN Novel indole inhibitors of IMPDH from fragments: synthesis and initial structure-activity relationships. Bioorg Med Chem Lett. 2006 May 1;16(9):2539-42. DM7DTRM RU https://pubmed.ncbi.nlm.nih.gov/16483773 DMFVSBK DI DMFVSBK DMFVSBK DN 1-Methoxy-3-(oxiran-2-ylmethoxy)-9H-xanthen-9-one DMFVSBK MI TT0IHXV DMFVSBK MN DNA topoisomerase II (TOP2) DMFVSBK MT DTT DMFVSBK MA Inhibitor DMFVSBK RN Synthesis and pharmacological evaluation of new methyloxiranylmethoxyxanthone analogues. Eur J Med Chem. 2010 Sep;45(9):4221-8. DMFVSBK RU https://pubmed.ncbi.nlm.nih.gov/20619511 DM8YQ2O DI DM8YQ2O DM8YQ2O DN 1-Methoxy-6-phenyl-6H-benzo[c]chromen-8-ylamine DM8YQ2O MI TTOZRK6 DM8YQ2O MN Glucocorticoid receptor messenger RNA (GCR mRNA) DM8YQ2O MT DTT DM8YQ2O MA Inhibitor DM8YQ2O RN Synthesis and biological evaluation of novel, selective, nonsteroidal glucocorticoid receptor antagonists. Bioorg Med Chem Lett. 2004 May 3;14(9):2079-82. DM8YQ2O RU https://pubmed.ncbi.nlm.nih.gov/15080982 DM2D5HB DI DM2D5HB DM2D5HB DN 1-Methoxy-6-phenyl-6H-benzo[c]chromene DM2D5HB MI TTOZRK6 DM2D5HB MN Glucocorticoid receptor messenger RNA (GCR mRNA) DM2D5HB MT DTT DM2D5HB MA Inhibitor DM2D5HB RN Synthesis and biological evaluation of novel, selective, nonsteroidal glucocorticoid receptor antagonists. Bioorg Med Chem Lett. 2004 May 3;14(9):2079-82. DM2D5HB RU https://pubmed.ncbi.nlm.nih.gov/15080982 DMAUZHJ DI DMAUZHJ DMAUZHJ DN 1-methoxy-9-aminomethyl-9,10-dihydroanthracene DMAUZHJ MI TTJQOD7 DMAUZHJ MN 5-HT 2A receptor (HTR2A) DMAUZHJ MT DTT DMAUZHJ MA Inhibitor DMAUZHJ RN Methoxy-substituted 9-aminomethyl-9,10-dihydroanthracene (AMDA) derivatives exhibit differential binding affinities at the 5-HT(2A) receptor. Bioorg Med Chem Lett. 2008 Oct 1;18(19):5268-71. DMAUZHJ RU https://pubmed.ncbi.nlm.nih.gov/18774714 DM9KCXI DI DM9KCXI DM9KCXI DN 1-Methyl-1-(4-pyrrolidin-1-yl-but-2-ynyl)-urea DM9KCXI MI TTZ9SOR DM9KCXI MN Muscarinic acetylcholine receptor M1 (CHRM1) DM9KCXI MT DTT DM9KCXI MA Inhibitor DM9KCXI RN Urea and 2-imidazolidone derivatives of the muscarinic agents oxotremorine and N-methyl-N-(1-methyl-4-pyrrolidino-2-butynyl)acetamide. J Med Chem. 1992 Aug 21;35(17):3270-9. DM9KCXI RU https://pubmed.ncbi.nlm.nih.gov/1507212 DM9KCXI DI DM9KCXI DM9KCXI DN 1-Methyl-1-(4-pyrrolidin-1-yl-but-2-ynyl)-urea DM9KCXI MI TTYEG6Q DM9KCXI MN Muscarinic acetylcholine receptor M2 (CHRM2) DM9KCXI MT DTT DM9KCXI MA Inhibitor DM9KCXI RN Urea and 2-imidazolidone derivatives of the muscarinic agents oxotremorine and N-methyl-N-(1-methyl-4-pyrrolidino-2-butynyl)acetamide. J Med Chem. 1992 Aug 21;35(17):3270-9. DM9KCXI RU https://pubmed.ncbi.nlm.nih.gov/1507212 DM9KCXI DI DM9KCXI DM9KCXI DN 1-Methyl-1-(4-pyrrolidin-1-yl-but-2-ynyl)-urea DM9KCXI MI TTQ13Z5 DM9KCXI MN Muscarinic acetylcholine receptor M3 (CHRM3) DM9KCXI MT DTT DM9KCXI MA Inhibitor DM9KCXI RN Urea and 2-imidazolidone derivatives of the muscarinic agents oxotremorine and N-methyl-N-(1-methyl-4-pyrrolidino-2-butynyl)acetamide. J Med Chem. 1992 Aug 21;35(17):3270-9. DM9KCXI RU https://pubmed.ncbi.nlm.nih.gov/1507212 DM9KCXI DI DM9KCXI DM9KCXI DN 1-Methyl-1-(4-pyrrolidin-1-yl-but-2-ynyl)-urea DM9KCXI MI TTQ3JTF DM9KCXI MN Muscarinic acetylcholine receptor M4 (CHRM4) DM9KCXI MT DTT DM9KCXI MA Inhibitor DM9KCXI RN Urea and 2-imidazolidone derivatives of the muscarinic agents oxotremorine and N-methyl-N-(1-methyl-4-pyrrolidino-2-butynyl)acetamide. J Med Chem. 1992 Aug 21;35(17):3270-9. DM9KCXI RU https://pubmed.ncbi.nlm.nih.gov/1507212 DM9KCXI DI DM9KCXI DM9KCXI DN 1-Methyl-1-(4-pyrrolidin-1-yl-but-2-ynyl)-urea DM9KCXI MI TTH18TF DM9KCXI MN Muscarinic acetylcholine receptor M5 (CHRM5) DM9KCXI MT DTT DM9KCXI MA Inhibitor DM9KCXI RN Urea and 2-imidazolidone derivatives of the muscarinic agents oxotremorine and N-methyl-N-(1-methyl-4-pyrrolidino-2-butynyl)acetamide. J Med Chem. 1992 Aug 21;35(17):3270-9. DM9KCXI RU https://pubmed.ncbi.nlm.nih.gov/1507212 DMI6P91 DI DMI6P91 DMI6P91 DN 1-Methyl-1,2,3,4-tetrahydro-isoquinoline-6,7-diol DMI6P91 MI TTEX248 DMI6P91 MN Dopamine D2 receptor (D2R) DMI6P91 MT DTT DMI6P91 MA Inhibitor DMI6P91 RN D4 dopamine receptor-selective compounds from the Chinese plant Phoebe chekiangensis, Bioorg. Med. Chem. Lett. 7(9):1207-1212 (1997). DMI6P91 RU http://www.sciencedirect.com/science/article/pii/S0960894X97001947 DM1BGQN DI DM1BGQN DM1BGQN DN 1-Methyl-1,2-dihydro-indazol-3-one DM1BGQN MI TT2J34L DM1BGQN MN Arachidonate 5-lipoxygenase (5-LOX) DM1BGQN MT DTT DM1BGQN MA Inhibitor DM1BGQN RN Indazolinones, a new series of redox-active 5-lipoxygenase inhibitors with built-in selectivity and oral activity. J Med Chem. 1991 Mar;34(3):1028-36. DM1BGQN RU https://pubmed.ncbi.nlm.nih.gov/1848292 DMMX7V8 DI DMMX7V8 DMMX7V8 DN 1-Methyl-1,3-dihydro-indol-2-one DMMX7V8 MI TTSQIFT DMMX7V8 MN 5-HT 1A receptor (HTR1A) DMMX7V8 MT DTT DMMX7V8 MA Inhibitor DMMX7V8 RN Influence of the terminal amide fragment geometry in some 3-arylideneindolin-2(1H)-ones on their 5-HT1A/5-HT2A receptor activity. Bioorg Med Chem Lett. 2001 May 7;11(9):1229-31. DMMX7V8 RU https://pubmed.ncbi.nlm.nih.gov/11354383 DMMX7V8 DI DMMX7V8 DMMX7V8 DN 1-Methyl-1,3-dihydro-indol-2-one DMMX7V8 MI TTJQOD7 DMMX7V8 MN 5-HT 2A receptor (HTR2A) DMMX7V8 MT DTT DMMX7V8 MA Inhibitor DMMX7V8 RN Influence of the terminal amide fragment geometry in some 3-arylideneindolin-2(1H)-ones on their 5-HT1A/5-HT2A receptor activity. Bioorg Med Chem Lett. 2001 May 7;11(9):1229-31. DMMX7V8 RU https://pubmed.ncbi.nlm.nih.gov/11354383 DMPW75L DI DMPW75L DMPW75L DN 1-methyl-1H-indole-2,3-dione DMPW75L MI TTMF541 DMPW75L MN Liver carboxylesterase (CES1) DMPW75L MT DTT DMPW75L MA Inhibitor DMPW75L RN Selective inhibition of carboxylesterases by isatins, indole-2,3-diones. J Med Chem. 2007 Apr 19;50(8):1876-85. DMPW75L RU https://pubmed.ncbi.nlm.nih.gov/17378546 DMDZ1FR DI DMDZ1FR DMDZ1FR DN 1-methyl-1H-indole-3-carbaldehyde DMDZ1FR MI TTTB4UP DMDZ1FR MN Inosine-5'-monophosphate dehydrogenase 2 (IMPDH2) DMDZ1FR MT DTT DMDZ1FR MA Inhibitor DMDZ1FR RN Low molecular weight indole fragments as IMPDH inhibitors. Bioorg Med Chem Lett. 2006 May 1;16(9):2535-8. DMDZ1FR RU https://pubmed.ncbi.nlm.nih.gov/16483769 DML5FQT DI DML5FQT DML5FQT DN 1-methyl-1H-indole-3-carbonitrile DML5FQT MI TTTB4UP DML5FQT MN Inosine-5'-monophosphate dehydrogenase 2 (IMPDH2) DML5FQT MT DTT DML5FQT MA Inhibitor DML5FQT RN Novel indole inhibitors of IMPDH from fragments: synthesis and initial structure-activity relationships. Bioorg Med Chem Lett. 2006 May 1;16(9):2539-42. DML5FQT RU https://pubmed.ncbi.nlm.nih.gov/16483773 DMUKAH6 DI DMUKAH6 DMUKAH6 DN 1-methyl-1H-indole-3-carboxamide DMUKAH6 MI TTTB4UP DMUKAH6 MN Inosine-5'-monophosphate dehydrogenase 2 (IMPDH2) DMUKAH6 MT DTT DMUKAH6 MA Inhibitor DMUKAH6 RN Low molecular weight indole fragments as IMPDH inhibitors. Bioorg Med Chem Lett. 2006 May 1;16(9):2535-8. DMUKAH6 RU https://pubmed.ncbi.nlm.nih.gov/16483769 DMYU348 DI DMYU348 DMYU348 DN 1-Methyl-2-(4-phenylsulfanyl-phenyl)-ethylamine DMYU348 MI TT3ROYC DMYU348 MN Serotonin transporter (SERT) DMYU348 MT DTT DMYU348 MA Inhibitor DMYU348 RN Synthesis and serotonin transporter activity of sulphur-substituted alpha-alkyl phenethylamines as a new class of anticancer agents. Eur J Med Chem. 2009 Dec;44(12):4862-88. DMYU348 RU https://pubmed.ncbi.nlm.nih.gov/19717215 DM5GELS DI DM5GELS DM5GELS DN 1-Methyl-2-Oxy-5,5-Dimethyl Pyrrolidine DM5GELS MI TTB2MXP DM5GELS MN Angiotensinogenase renin (REN) DM5GELS MT DTT DM5GELS MA Inhibitor DM5GELS RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DM5GELS RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMC3IGK DI DMC3IGK DMC3IGK DN 1-methyl-3-(phenylcarbamoyloxy)pyridinium bromide DMC3IGK MI TTEB0GD DMC3IGK MN Cholinesterase (BCHE) DMC3IGK MT DTT DMC3IGK MA Inhibitor DMC3IGK RN Long-acting anticholinesterases for myasthenia gravis: synthesis and activities of quaternary phenylcarbamates of neostigmine, pyridostigmine and physostigmine. Bioorg Med Chem. 2010 Jul 1;18(13):4687-93. DMC3IGK RU https://pubmed.ncbi.nlm.nih.gov/20627738 DMICQWN DI DMICQWN DMICQWN DN 1-METHYL-3-PHENYL-1H-PYRAZOL-5-YLSULFAMIC ACID DMICQWN MI TTELIN2 DMICQWN MN PTPN1 messenger RNA (PTPN1 mRNA) DMICQWN MT DTT DMICQWN MA Inhibitor DMICQWN RN DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Nucleic Acids Res. 2011 Jan;39(Database issue):D1035-41. DMICQWN RU https://pubmed.ncbi.nlm.nih.gov/21059682 DM90LWT DI DM90LWT DM90LWT DN 1-Methyl-3-propyl-3,7-dihydro-purine-2,6-dione DM90LWT MI TTZ97H5 DM90LWT MN Phosphodiesterase 4A (PDE4A) DM90LWT MT DTT DM90LWT MA Inhibitor DM90LWT RN Effects of alkyl substitutions of xanthine skeleton on bronchodilation. J Med Chem. 1992 Oct 30;35(22):4039-44. DM90LWT RU https://pubmed.ncbi.nlm.nih.gov/1331453 DM90LWT DI DM90LWT DM90LWT DN 1-Methyl-3-propyl-3,7-dihydro-purine-2,6-dione DM90LWT MI TTSKMI8 DM90LWT MN Phosphodiesterase 4D (PDE4D) DM90LWT MT DTT DM90LWT MA Inhibitor DM90LWT RN Effects of alkyl substitutions of xanthine skeleton on bronchodilation. J Med Chem. 1992 Oct 30;35(22):4039-44. DM90LWT RU https://pubmed.ncbi.nlm.nih.gov/1331453 DMBWSCR DI DMBWSCR DMBWSCR DN 1-Methyl-4-(1-phenyl-ethyl)-piperazine DMBWSCR MI TTD0CIQ DMBWSCR MN Melanocortin receptor 4 (MC4R) DMBWSCR MT DTT DMBWSCR MA Inhibitor DMBWSCR RN Privileged structure based ligands for melanocortin receptors--substituted benzylic piperazine derivatives. Bioorg Med Chem Lett. 2005 Nov 15;15(22):4973-8. DMBWSCR RU https://pubmed.ncbi.nlm.nih.gov/16169215 DMPWB8G DI DMPWB8G DMPWB8G DN 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine DMPWB8G MI TTGP7BY DMPWB8G MN Monoamine oxidase type B (MAO-B) DMPWB8G MT DTT DMPWB8G MA Inhibitor DMPWB8G RN Further explorations of unnatural alkaloids. J Nat Prod. 1985 Nov-Dec;48(6):878-93. DMPWB8G RU https://pubmed.ncbi.nlm.nih.gov/3879267 DM6XFMT DI DM6XFMT DM6XFMT DN 1-Methyl-4-p-tolyl-piperidine-4-carbonitrile DM6XFMT MI TT3ROYC DM6XFMT MN Serotonin transporter (SERT) DM6XFMT MT DTT DM6XFMT MA Inhibitor DM6XFMT RN Synthesis, dopamine and serotonin transporter binding affinities of novel analogues of meperidine. Bioorg Med Chem Lett. 1999 Dec 6;9(23):3273-6. DM6XFMT RU https://pubmed.ncbi.nlm.nih.gov/10612583 DM4HS92 DI DM4HS92 DM4HS92 DN 1-Methyl-5-(4-phenylazo-phenyl)-piperidin-2-one DM4HS92 MI TTTU72V DM4HS92 MN Steroid 5-alpha-reductase 1 (SRD5A1) DM4HS92 MT DTT DM4HS92 MA Inhibitor DM4HS92 RN Simple bi- and tricyclic inhibitors of human steroid 5alpha-reductase. Bioorg Med Chem Lett. 2000 Sep 4;10(17):1909-11. DM4HS92 RU https://pubmed.ncbi.nlm.nih.gov/10987415 DMX2FWN DI DMX2FWN DMX2FWN DN 1-Methyl-5-oxa-spiro[2.4]heptan-4-one DMX2FWN MI TT1MPAY DMX2FWN MN GABA(A) receptor alpha-1 (GABRA1) DMX2FWN MT DTT DMX2FWN MA Inhibitor DMX2FWN RN Alpha-spirocyclopentyl- and alpha-spirocyclopropyl-gamma-butyrolactones: conformationally constrained derivatives of anticonvulsant and convulsant ... J Med Chem. 1994 Jan 21;37(2):275-86. DMX2FWN RU https://pubmed.ncbi.nlm.nih.gov/8295215 DMX2FWN DI DMX2FWN DMX2FWN DN 1-Methyl-5-oxa-spiro[2.4]heptan-4-one DMX2FWN MI TTZA1NY DMX2FWN MN GABA(A) receptor beta-2 (GABRB2) DMX2FWN MT DTT DMX2FWN MA Inhibitor DMX2FWN RN Alpha-spirocyclopentyl- and alpha-spirocyclopropyl-gamma-butyrolactones: conformationally constrained derivatives of anticonvulsant and convulsant ... J Med Chem. 1994 Jan 21;37(2):275-86. DMX2FWN RU https://pubmed.ncbi.nlm.nih.gov/8295215 DMX2FWN DI DMX2FWN DMX2FWN DN 1-Methyl-5-oxa-spiro[2.4]heptan-4-one DMX2FWN MI TT06RH5 DMX2FWN MN GABA(A) receptor gamma-2 (GABRG2) DMX2FWN MT DTT DMX2FWN MA Inhibitor DMX2FWN RN Alpha-spirocyclopentyl- and alpha-spirocyclopropyl-gamma-butyrolactones: conformationally constrained derivatives of anticonvulsant and convulsant ... J Med Chem. 1994 Jan 21;37(2):275-86. DMX2FWN RU https://pubmed.ncbi.nlm.nih.gov/8295215 DMX2FWN DI DMX2FWN DMX2FWN DN 1-Methyl-5-oxa-spiro[2.4]heptan-4-one DMX2FWN MI TTNJYV2 DMX2FWN MN Gamma-aminobutyric acid receptor (GAR) DMX2FWN MT DTT DMX2FWN MA Inhibitor DMX2FWN RN Alpha-spirocyclopentyl- and alpha-spirocyclopropyl-gamma-butyrolactones: conformationally constrained derivatives of anticonvulsant and convulsant ... J Med Chem. 1994 Jan 21;37(2):275-86. DMX2FWN RU https://pubmed.ncbi.nlm.nih.gov/8295215 DMB3JO2 DI DMB3JO2 DMB3JO2 DN 1-Methyl-5-phenyl-piperidin-2-one DMB3JO2 MI TTTU72V DMB3JO2 MN Steroid 5-alpha-reductase 1 (SRD5A1) DMB3JO2 MT DTT DMB3JO2 MA Inhibitor DMB3JO2 RN Simple bi- and tricyclic inhibitors of human steroid 5alpha-reductase. Bioorg Med Chem Lett. 2000 Sep 4;10(17):1909-11. DMB3JO2 RU https://pubmed.ncbi.nlm.nih.gov/10987415 DMSTH24 DI DMSTH24 DMSTH24 DN 1-Methyl-8-phenyl-3,7-dihydro-purine-2,6-dione DMSTH24 MI TTK25J1 DMSTH24 MN Adenosine A1 receptor (ADORA1) DMSTH24 MT DTT DMSTH24 MA Inhibitor DMSTH24 RN Effects of 8-phenyl and 8-cycloalkyl substituents on the activity of mono-, di-, and trisubstituted alkylxanthines with substitution at the 1-, 3-,... J Med Chem. 1989 Jun;32(6):1231-7. DMSTH24 RU https://pubmed.ncbi.nlm.nih.gov/2724296 DMSTH24 DI DMSTH24 DMSTH24 DN 1-Methyl-8-phenyl-3,7-dihydro-purine-2,6-dione DMSTH24 MI TTM2AOE DMSTH24 MN Adenosine A2a receptor (ADORA2A) DMSTH24 MT DTT DMSTH24 MA Inhibitor DMSTH24 RN Preparation, properties, reactions, and adenosine receptor affinities of sulfophenylxanthine nitrophenyl esters: toward the development of sulfonic... J Med Chem. 2004 Feb 12;47(4):1031-43. DMSTH24 RU https://pubmed.ncbi.nlm.nih.gov/14761205 DMDIH07 DI DMDIH07 DMDIH07 DN 1-methylcyclopropanecarboxylic acid DMDIH07 MI TT0FYAN DMDIH07 MN Free fatty acid receptor 2 (FFAR2) DMDIH07 MT DTT DMDIH07 MA Agonist DMDIH07 RN Selective orthosteric free fatty acid receptor 2 (FFA2) agonists: identification of the structural and chemical requirements for selective activation of FFA2 versus FFA3. J Biol Chem. 2011 Mar 25;286(12):10628-40. DMDIH07 RU https://pubmed.ncbi.nlm.nih.gov/21220428 DMDIH07 DI DMDIH07 DMDIH07 DN 1-methylcyclopropanecarboxylic acid DMDIH07 MI TTXDOHN DMDIH07 MN Free fatty acid receptor 3 (FFAR3) DMDIH07 MT DTT DMDIH07 MA Agonist DMDIH07 RN Selective orthosteric free fatty acid receptor 2 (FFA2) agonists: identification of the structural and chemical requirements for selective activation of FFA2 versus FFA3. J Biol Chem. 2011 Mar 25;286(12):10628-40. DMDIH07 RU https://pubmed.ncbi.nlm.nih.gov/21220428 DMFR7JW DI DMFR7JW DMFR7JW DN 1-Methyloxy-4-Sulfone-Benzene DMFR7JW MI TTHY57M DMFR7JW MN Matrix metalloproteinase-13 (MMP-13) DMFR7JW MT DTT DMFR7JW MA Inhibitor DMFR7JW RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMFR7JW RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMFR7JW DI DMFR7JW DMFR7JW DN 1-Methyloxy-4-Sulfone-Benzene DMFR7JW MI TTUZ2L5 DMFR7JW MN Matrix metalloproteinase-3 (MMP-3) DMFR7JW MT DTT DMFR7JW MA Inhibitor DMFR7JW RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMFR7JW RU https://pubmed.ncbi.nlm.nih.gov/17139284 DM2WQ1E DI DM2WQ1E DM2WQ1E DN 1-METHYLXANTHINE DM2WQ1E MI TTK25J1 DM2WQ1E MN Adenosine A1 receptor (ADORA1) DM2WQ1E MT DTT DM2WQ1E MA Inhibitor DM2WQ1E RN Benzo[1,2-c:5,4-c']dipyrazoles: non-xanthine adenosine antagonists. J Med Chem. 1988 Oct;31(10):2034-9. DM2WQ1E RU https://pubmed.ncbi.nlm.nih.gov/3172141 DM2WQ1E DI DM2WQ1E DM2WQ1E DN 1-METHYLXANTHINE DM2WQ1E MI TTM2AOE DM2WQ1E MN Adenosine A2a receptor (ADORA2A) DM2WQ1E MT DTT DM2WQ1E MA Inhibitor DM2WQ1E RN Benzo[1,2-c:5,4-c']dipyrazoles: non-xanthine adenosine antagonists. J Med Chem. 1988 Oct;31(10):2034-9. DM2WQ1E RU https://pubmed.ncbi.nlm.nih.gov/3172141 DM2WQ1E DI DM2WQ1E DM2WQ1E DN 1-METHYLXANTHINE DM2WQ1E MI TTNE7KG DM2WQ1E MN Adenosine A2b receptor (ADORA2B) DM2WQ1E MT DTT DM2WQ1E MA Inhibitor DM2WQ1E RN Benzo[1,2-c:5,4-c']dipyrazoles: non-xanthine adenosine antagonists. J Med Chem. 1988 Oct;31(10):2034-9. DM2WQ1E RU https://pubmed.ncbi.nlm.nih.gov/3172141 DMYOJ01 DI DMYOJ01 DMYOJ01 DN 1-Morpholin-4-yl-benzo[f]chromen-3-one DMYOJ01 MI TTK3PY9 DMYOJ01 MN DNA-dependent protein kinase catalytic (PRKDC) DMYOJ01 MT DTT DMYOJ01 MA Inhibitor DMYOJ01 RN Selective benzopyranone and pyrimido[2,1-a]isoquinolin-4-one inhibitors of DNA-dependent protein kinase: synthesis, structure-activity studies, and... J Med Chem. 2005 Jan 27;48(2):569-85. DMYOJ01 RU https://pubmed.ncbi.nlm.nih.gov/15658870 DM0A1YI DI DM0A1YI DM0A1YI DN 1na DM0A1YI MI TTAU4D6 DM0A1YI MN E-selectin (SELE) DM0A1YI MT DTT DM0A1YI MA Inhibitor DM0A1YI RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DM0A1YI RU https://pubmed.ncbi.nlm.nih.gov/17139284 DM0A1YI DI DM0A1YI DM0A1YI DN 1na DM0A1YI MI TTE5VG0 DM0A1YI MN P-selectin (SELP) DM0A1YI MT DTT DM0A1YI MA Inhibitor DM0A1YI RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DM0A1YI RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMF87Z5 DI DMF87Z5 DMF87Z5 DN 1-N-Acetyl-Beta-D-Glucosamine DMF87Z5 MI TTZHY6R DMF87Z5 MN Glycogen phosphorylase muscle form (GP) DMF87Z5 MT DTT DMF87Z5 MA Inhibitor DMF87Z5 RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMF87Z5 RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMTBZJL DI DMTBZJL DMTBZJL DN 1-Naphthalen-2-yl-1H-imidazole DMTBZJL MI TTSZLWK DMTBZJL MN Aromatase (CYP19A1) DMTBZJL MT DTT DMTBZJL MA Inhibitor DMTBZJL RN Heteroaryl-substituted naphthalenes and structurally modified derivatives: selective inhibitors of CYP11B2 for the treatment of congestive heart fa... J Med Chem. 2005 Oct 20;48(21):6632-42. DMTBZJL RU https://pubmed.ncbi.nlm.nih.gov/16220979 DMTBZJL DI DMTBZJL DMTBZJL DN 1-Naphthalen-2-yl-1H-imidazole DMTBZJL MI TTIQUX7 DMTBZJL MN Steroid 11-beta-hydroxylase (CYP11B1) DMTBZJL MT DTT DMTBZJL MA Inhibitor DMTBZJL RN Heteroaryl-substituted naphthalenes and structurally modified derivatives: selective inhibitors of CYP11B2 for the treatment of congestive heart fa... J Med Chem. 2005 Oct 20;48(21):6632-42. DMTBZJL RU https://pubmed.ncbi.nlm.nih.gov/16220979 DMU04ZQ DI DMU04ZQ DMU04ZQ DN 1-naphthalen-2-yl-2-pyrrolidin-1-yl-pentan-1-one DMU04ZQ MI TTVBI8W DMU04ZQ MN Dopamine transporter (DAT) DMU04ZQ MT DTT DMU04ZQ MA Inhibitor DMU04ZQ RN 1-(4-Methylphenyl)-2-pyrrolidin-1-yl-pentan-1-one (Pyrovalerone) analogues: a promising class of monoamine uptake inhibitors. J Med Chem. 2006 Feb 23;49(4):1420-32. DMU04ZQ RU https://pubmed.ncbi.nlm.nih.gov/16480278 DMU04ZQ DI DMU04ZQ DMU04ZQ DN 1-naphthalen-2-yl-2-pyrrolidin-1-yl-pentan-1-one DMU04ZQ MI TTAWNKZ DMU04ZQ MN Norepinephrine transporter (NET) DMU04ZQ MT DTT DMU04ZQ MA Inhibitor DMU04ZQ RN 1-(4-Methylphenyl)-2-pyrrolidin-1-yl-pentan-1-one (Pyrovalerone) analogues: a promising class of monoamine uptake inhibitors. J Med Chem. 2006 Feb 23;49(4):1420-32. DMU04ZQ RU https://pubmed.ncbi.nlm.nih.gov/16480278 DMU04ZQ DI DMU04ZQ DMU04ZQ DN 1-naphthalen-2-yl-2-pyrrolidin-1-yl-pentan-1-one DMU04ZQ MI TT3ROYC DMU04ZQ MN Serotonin transporter (SERT) DMU04ZQ MT DTT DMU04ZQ MA Inhibitor DMU04ZQ RN 1-(4-Methylphenyl)-2-pyrrolidin-1-yl-pentan-1-one (Pyrovalerone) analogues: a promising class of monoamine uptake inhibitors. J Med Chem. 2006 Feb 23;49(4):1420-32. DMU04ZQ RU https://pubmed.ncbi.nlm.nih.gov/16480278 DMJK0MF DI DMJK0MF DMJK0MF DN 1-Naphthalen-2-yl-piperazine DMJK0MF MI TTSQIFT DMJK0MF MN 5-HT 1A receptor (HTR1A) DMJK0MF MT DTT DMJK0MF MA Inhibitor DMJK0MF RN 5-HT1 and 5-HT2 binding characteristics of some quipazine analogues. J Med Chem. 1986 Nov;29(11):2375-80. DMJK0MF RU https://pubmed.ncbi.nlm.nih.gov/3783595 DMJK0MF DI DMJK0MF DMJK0MF DN 1-Naphthalen-2-yl-piperazine DMJK0MF MI TTK8CXU DMJK0MF MN 5-HT 1B receptor (HTR1B) DMJK0MF MT DTT DMJK0MF MA Inhibitor DMJK0MF RN 5-HT1B receptor antagonist properties of novel arylpiperazide derivatives of 1-naphthylpiperazine. J Med Chem. 1997 Nov 21;40(24):3974-8. DMJK0MF RU https://pubmed.ncbi.nlm.nih.gov/9397179 DMJK0MF DI DMJK0MF DMJK0MF DN 1-Naphthalen-2-yl-piperazine DMJK0MF MI TT6MSOK DMJK0MF MN 5-HT 1D receptor (HTR1D) DMJK0MF MT DTT DMJK0MF MA Inhibitor DMJK0MF RN 5-HT1 and 5-HT2 binding characteristics of some quipazine analogues. J Med Chem. 1986 Nov;29(11):2375-80. DMJK0MF RU https://pubmed.ncbi.nlm.nih.gov/3783595 DMJK0MF DI DMJK0MF DMJK0MF DN 1-Naphthalen-2-yl-piperazine DMJK0MF MI TTJQOD7 DMJK0MF MN 5-HT 2A receptor (HTR2A) DMJK0MF MT DTT DMJK0MF MA Inhibitor DMJK0MF RN 5-HT1 and 5-HT2 binding characteristics of some quipazine analogues. J Med Chem. 1986 Nov;29(11):2375-80. DMJK0MF RU https://pubmed.ncbi.nlm.nih.gov/3783595 DM6BIWK DI DM6BIWK DM6BIWK DN 1-naphthylpiperazine DM6BIWK MI TTSQIFT DM6BIWK MN 5-HT 1A receptor (HTR1A) DM6BIWK MT DTT DM6BIWK MA Agonist DM6BIWK RN 5-HT1B receptor antagonist properties of novel arylpiperazide derivatives of 1-naphthylpiperazine. J Med Chem. 1997 Nov 21;40(24):3974-8. DM6BIWK RU https://pubmed.ncbi.nlm.nih.gov/9397179 DM6BIWK DI DM6BIWK DM6BIWK DN 1-naphthylpiperazine DM6BIWK MI TTK8CXU DM6BIWK MN 5-HT 1B receptor (HTR1B) DM6BIWK MT DTT DM6BIWK MA Agonist DM6BIWK RN Two amino acid differences in the sixth transmembrane domain are partially responsible for the pharmacological differences between the 5-HT1D beta and 5-HT1E 5-hydroxytryptamine receptors. J Neurochem. 1996 Nov;67(5):2096-103. DM6BIWK RU https://pubmed.ncbi.nlm.nih.gov/8863519 DM6BIWK DI DM6BIWK DM6BIWK DN 1-naphthylpiperazine DM6BIWK MI TT6MSOK DM6BIWK MN 5-HT 1D receptor (HTR1D) DM6BIWK MT DTT DM6BIWK MA Agonist DM6BIWK RN Human serotonin 1D receptor is encoded by a subfamily of two distinct genes: 5-HT1D alpha and 5-HT1D beta. Proc Natl Acad Sci U S A. 1992 Apr 15;89(8):3630-4. DM6BIWK RU https://pubmed.ncbi.nlm.nih.gov/1565658 DM6BIWK DI DM6BIWK DM6BIWK DN 1-naphthylpiperazine DM6BIWK MI TTCPG9S DM6BIWK MN 5-HT 1E receptor (HTR1E) DM6BIWK MT DTT DM6BIWK MA Antagonist DM6BIWK RN Molecular cloning and pharmacological characterization of the guinea pig 5-HT1E receptor. Eur J Pharmacol. 2004 Jan 26;484(2-3):127-39. DM6BIWK RU https://pubmed.ncbi.nlm.nih.gov/14744596 DM6BIWK DI DM6BIWK DM6BIWK DN 1-naphthylpiperazine DM6BIWK MI TT0MI3F DM6BIWK MN 5-HT 1F receptor (HTR1F) DM6BIWK MT DTT DM6BIWK MA Antagonist DM6BIWK RN Cloning and characterization of the guinea pig 5-HT1F receptor subtype: a comparison of the pharmacological profile to the human species homolog. Neuropharmacology. 1997 Apr-May;36(4-5):569-76. DM6BIWK RU https://pubmed.ncbi.nlm.nih.gov/9225282 DM6BIWK DI DM6BIWK DM6BIWK DN 1-naphthylpiperazine DM6BIWK MI TTJQOD7 DM6BIWK MN 5-HT 2A receptor (HTR2A) DM6BIWK MT DTT DM6BIWK MA Inhibitor DM6BIWK RN 5-HT1 and 5-HT2 binding characteristics of some quipazine analogues. J Med Chem. 1986 Nov;29(11):2375-80. DM6BIWK RU https://pubmed.ncbi.nlm.nih.gov/3783595 DM6BIWK DI DM6BIWK DM6BIWK DN 1-naphthylpiperazine DM6BIWK MI TT0K1SC DM6BIWK MN 5-HT 2B receptor (HTR2B) DM6BIWK MT DTT DM6BIWK MA Antagonist DM6BIWK RN Pharmacological characteristics of the newly cloned rat 5-hydroxytryptamine2F receptor. Mol Pharmacol. 1993 Mar;43(3):419-26. DM6BIWK RU https://pubmed.ncbi.nlm.nih.gov/8450835 DM6BIWK DI DM6BIWK DM6BIWK DN 1-naphthylpiperazine DM6BIWK MI TTJS8PY DM6BIWK MN 5-HT 6 receptor (HTR6) DM6BIWK MT DTT DM6BIWK MA Agonist DM6BIWK RN Cloning and expression of a novel serotonin receptor with high affinity for tricyclic psychotropic drugs. Mol Pharmacol. 1993 Mar;43(3):320-7. DM6BIWK RU https://pubmed.ncbi.nlm.nih.gov/7680751 DM6BIWK DI DM6BIWK DM6BIWK DN 1-naphthylpiperazine DM6BIWK MI TTO9X1H DM6BIWK MN 5-HT 7 receptor (HTR7) DM6BIWK MT DTT DM6BIWK MA Agonist DM6BIWK RN Cloning of a novel human serotonin receptor (5-HT7) positively linked to adenylate cyclase. J Biol Chem. 1993 Nov 5;268(31):23422-6. DM6BIWK RU https://pubmed.ncbi.nlm.nih.gov/8226867 DMP6VOK DI DMP6VOK DMP6VOK DN 1-nitro-2-(2-nitrophenylsulfonyl)benzene DMP6VOK MI TT84ETX DMP6VOK MN Human immunodeficiency virus Reverse transcriptase (HIV RT) DMP6VOK MT DTT DMP6VOK MA Inhibitor DMP6VOK RN 2-Amino-6-arylsulfonylbenzonitriles as non-nucleoside reverse transcriptase inhibitors of HIV-1. J Med Chem. 2001 Jun 7;44(12):1866-82. DMP6VOK RU https://pubmed.ncbi.nlm.nih.gov/11384233 DM9OJ7T DI DM9OJ7T DM9OJ7T DN 1-Octyl-3-(1-propionylpiperidin-4-yl)urea DM9OJ7T MI TT7WVHI DM9OJ7T MN Soluble epoxide hydrolase (EPHX2) DM9OJ7T MT DTT DM9OJ7T MA Inhibitor DM9OJ7T RN 1-Aryl-3-(1-acylpiperidin-4-yl)urea inhibitors of human and murine soluble epoxide hydrolase: structure-activity relationships, pharmacokinetics, a... J Med Chem. 2010 Oct 14;53(19):7067-75. DM9OJ7T RU https://pubmed.ncbi.nlm.nih.gov/20812725 DMYHMEK DI DMYHMEK DMYHMEK DN 1-OH-PGE1 DMYHMEK MI TT79WV3 DMYHMEK MN Prostaglandin E2 receptor EP4 (PTGER4) DMYHMEK MT DTT DMYHMEK MA Agonist DMYHMEK RN Ligand binding specificities of the eight types and subtypes of the mouse prostanoid receptors expressed in Chinese hamster ovary cells. Br J Pharmacol. 1997 Sep;122(2):217-24. DMYHMEK RU https://pubmed.ncbi.nlm.nih.gov/9313928 DM5KU8S DI DM5KU8S DM5KU8S DN 1-oleoyl glycerol DM5KU8S MI TT7QNVC DM5KU8S MN Glucose-dependent insulinotropic receptor (GPR119) DM5KU8S MT DTT DM5KU8S MA Agonist DM5KU8S RN 2-Oleoyl glycerol is a GPR119 agonist and signals GLP-1 release in humans. J Clin Endocrinol Metab. 2011 Sep;96(9):E1409-17. DM5KU8S RU https://pubmed.ncbi.nlm.nih.gov/21778222 DMPMGLO DI DMPMGLO DMPMGLO DN 1-Oxazolo[4,5-b]pyridin-2-yl-6-phenyl-hexan-1-one DMPMGLO MI TTDP1UC DMPMGLO MN Fatty acid amide hydrolase (FAAH) DMPMGLO MT DTT DMPMGLO MA Inhibitor DMPMGLO RN The endocannabinoid system: drug targets, lead compounds, and potential therapeutic applications. J Med Chem. 2005 Aug 11;48(16):5059-87. DMPMGLO RU https://pubmed.ncbi.nlm.nih.gov/16078824 DM9BY8D DI DM9BY8D DM9BY8D DN 1-Oxazolo[4,5-b]pyridin-2-yl-octadec-9-yn-1-one DM9BY8D MI TTDP1UC DM9BY8D MN Fatty acid amide hydrolase (FAAH) DM9BY8D MT DTT DM9BY8D MA Inhibitor DM9BY8D RN Discovery of a potent, selective, and efficacious class of reversible alpha-ketoheterocycle inhibitors of fatty acid amide hydrolase effective as a... J Med Chem. 2005 Mar 24;48(6):1849-56. DM9BY8D RU https://pubmed.ncbi.nlm.nih.gov/15771430 DM9ZK0M DI DM9ZK0M DM9ZK0M DN 1-palmitoyl-lysophosphatidylcholine DM9ZK0M MI TT7QNVC DM9ZK0M MN Glucose-dependent insulinotropic receptor (GPR119) DM9ZK0M MT DTT DM9ZK0M MA Agonist DM9ZK0M RN Lysophosphatidylcholine enhances glucose-dependent insulin secretion via an orphan G-protein-coupled receptor. Biochem Biophys Res Commun. 2005 Jan 28;326(4):744-51. DM9ZK0M RU https://pubmed.ncbi.nlm.nih.gov/15607732 DM9PNTQ DI DM9PNTQ DM9PNTQ DN 1-pentafluorophenylamido-5-sulfonamidoindane DM9PNTQ MI TTHQPL7 DM9PNTQ MN Carbonic anhydrase I (CA-I) DM9PNTQ MT DTT DM9PNTQ MA Inhibitor DM9PNTQ RN Indanesulfonamides as carbonic anhydrase inhibitors. Toward structure-based design of selective inhibitors of the tumor-associated isozyme CA IX. J Med Chem. 2006 May 4;49(9):2743-9. DM9PNTQ RU https://pubmed.ncbi.nlm.nih.gov/16640335 DM9PNTQ DI DM9PNTQ DM9PNTQ DN 1-pentafluorophenylamido-5-sulfonamidoindane DM9PNTQ MI TTANPDJ DM9PNTQ MN Carbonic anhydrase II (CA-II) DM9PNTQ MT DTT DM9PNTQ MA Inhibitor DM9PNTQ RN Indanesulfonamides as carbonic anhydrase inhibitors. Toward structure-based design of selective inhibitors of the tumor-associated isozyme CA IX. J Med Chem. 2006 May 4;49(9):2743-9. DM9PNTQ RU https://pubmed.ncbi.nlm.nih.gov/16640335 DM9PNTQ DI DM9PNTQ DM9PNTQ DN 1-pentafluorophenylamido-5-sulfonamidoindane DM9PNTQ MI TT2LVK8 DM9PNTQ MN Carbonic anhydrase IX (CA-IX) DM9PNTQ MT DTT DM9PNTQ MA Inhibitor DM9PNTQ RN Indanesulfonamides as carbonic anhydrase inhibitors. Toward structure-based design of selective inhibitors of the tumor-associated isozyme CA IX. J Med Chem. 2006 May 4;49(9):2743-9. DM9PNTQ RU https://pubmed.ncbi.nlm.nih.gov/16640335 DMNUAB9 DI DMNUAB9 DMNUAB9 DN 1-pentenyl-4-(aminosulfonyl)benzoate DMNUAB9 MI TTANPDJ DMNUAB9 MN Carbonic anhydrase II (CA-II) DMNUAB9 MT DTT DMNUAB9 MA Inhibitor DMNUAB9 RN Synthesis and structure-activity relationships of novel benzene sulfonamides with potent binding affinity for bovine carbonic anhydrase II. Bioorg Med Chem Lett. 2005 Dec 15;15(24):5429-33. DMNUAB9 RU https://pubmed.ncbi.nlm.nih.gov/16213706 DMA29SX DI DMA29SX DMA29SX DN 1-Phenethyl-3,7-dihydro-purine-2,6-dione DMA29SX MI TTJFY5U DMA29SX MN Adenosine A3 receptor (ADORA3) DMA29SX MT DTT DMA29SX MA Inhibitor DMA29SX RN Structure-activity relationships at human and rat A2B adenosine receptors of xanthine derivatives substituted at the 1-, 3-, 7-, and 8-positions. J Med Chem. 2002 May 23;45(11):2131-8. DMA29SX RU https://pubmed.ncbi.nlm.nih.gov/12014951 DM32WSM DI DM32WSM DM32WSM DN 1-Phenethyl-3-[1,3,4]thiadiazol-2-yl-thiourea DM32WSM MI TT84ETX DM32WSM MN Human immunodeficiency virus Reverse transcriptase (HIV RT) DM32WSM MT DTT DM32WSM MA Inhibitor DM32WSM RN Phenethylthiazolethiourea (PETT) compounds, a new class of HIV-1 reverse transcriptase inhibitors. 1. Synthesis and basic structure-activity relati... J Med Chem. 1995 Dec 8;38(25):4929-36. DM32WSM RU https://pubmed.ncbi.nlm.nih.gov/8523406 DM0DH98 DI DM0DH98 DM0DH98 DN 1-phenyl-1-(piperidin-2-yl)propan-2-one DM0DH98 MI TTVBI8W DM0DH98 MN Dopamine transporter (DAT) DM0DH98 MT DTT DM0DH98 MA Inhibitor DM0DH98 RN Slow-onset, long-duration, alkyl analogues of methylphenidate with enhanced selectivity for the dopamine transporter. J Med Chem. 2007 Jan 25;50(2):219-32. DM0DH98 RU https://pubmed.ncbi.nlm.nih.gov/17228864 DMGV6BI DI DMGV6BI DMGV6BI DN 1-Phenyl-1H-benzoimidazol-5-ol DMGV6BI MI TT8FYO9 DMGV6BI MN Platelet-derived growth factor receptor alpha (PDGFRA) DMGV6BI MT DTT DMGV6BI MA Inhibitor DMGV6BI RN Structure-activity relationships for 1-phenylbenzimidazoles as selective ATP site inhibitors of the platelet-derived growth factor receptor. J Med Chem. 1998 Dec 31;41(27):5457-65. DMGV6BI RU https://pubmed.ncbi.nlm.nih.gov/9876115 DMGV6BI DI DMGV6BI DMGV6BI DN 1-Phenyl-1H-benzoimidazol-5-ol DMGV6BI MI TTI7421 DMGV6BI MN Platelet-derived growth factor receptor beta (PDGFRB) DMGV6BI MT DTT DMGV6BI MA Inhibitor DMGV6BI RN Structure-activity relationships for 1-phenylbenzimidazoles as selective ATP site inhibitors of the platelet-derived growth factor receptor. J Med Chem. 1998 Dec 31;41(27):5457-65. DMGV6BI RU https://pubmed.ncbi.nlm.nih.gov/9876115 DM8YPH0 DI DM8YPH0 DM8YPH0 DN 1-Phenyl-1H-benzoimidazole DM8YPH0 MI TT8FYO9 DM8YPH0 MN Platelet-derived growth factor receptor alpha (PDGFRA) DM8YPH0 MT DTT DM8YPH0 MA Inhibitor DM8YPH0 RN Structure-activity relationships for 1-phenylbenzimidazoles as selective ATP site inhibitors of the platelet-derived growth factor receptor. J Med Chem. 1998 Dec 31;41(27):5457-65. DM8YPH0 RU https://pubmed.ncbi.nlm.nih.gov/9876115 DM8YPH0 DI DM8YPH0 DM8YPH0 DN 1-Phenyl-1H-benzoimidazole DM8YPH0 MI TTI7421 DM8YPH0 MN Platelet-derived growth factor receptor beta (PDGFRB) DM8YPH0 MT DTT DM8YPH0 MA Inhibitor DM8YPH0 RN Structure-activity relationships for 1-phenylbenzimidazoles as selective ATP site inhibitors of the platelet-derived growth factor receptor. J Med Chem. 1998 Dec 31;41(27):5457-65. DM8YPH0 RU https://pubmed.ncbi.nlm.nih.gov/9876115 DM74RMP DI DM74RMP DM74RMP DN 1-phenyl-1H-indole-2,3-dione DM74RMP MI TTMF541 DM74RMP MN Liver carboxylesterase (CES1) DM74RMP MT DTT DM74RMP MA Inhibitor DM74RMP RN Selective inhibition of carboxylesterases by isatins, indole-2,3-diones. J Med Chem. 2007 Apr 19;50(8):1876-85. DM74RMP RU https://pubmed.ncbi.nlm.nih.gov/17378546 DMZM9AI DI DMZM9AI DMZM9AI DN 1-phenyl-2-(1-phenyl-1H-tetrazol-5-yloxy)ethanone DMZM9AI MI TTN7BL9 DMZM9AI MN Corticosteroid 11-beta-dehydrogenase 1 (HSD11B1) DMZM9AI MT DTT DMZM9AI MA Inhibitor DMZM9AI RN Modulation of 11beta-hydroxysteroid dehydrogenase type 1 activity by 1,5-substituted 1H-tetrazoles. Bioorg Med Chem Lett. 2010 Jun 1;20(11):3265-71. DMZM9AI RU https://pubmed.ncbi.nlm.nih.gov/20452767 DMW9CRT DI DMW9CRT DMW9CRT DN 1-Phenyl-2-p-tolyl-ethane-1,2-dione DMW9CRT MI TTMF541 DMW9CRT MN Liver carboxylesterase (CES1) DMW9CRT MT DTT DMW9CRT MA Inhibitor DMW9CRT RN Identification and characterization of novel benzil (diphenylethane-1,2-dione) analogues as inhibitors of mammalian carboxylesterases. J Med Chem. 2005 Apr 21;48(8):2906-15. DMW9CRT RU https://pubmed.ncbi.nlm.nih.gov/15828829 DM8EDI7 DI DM8EDI7 DM8EDI7 DN 1-Phenyl-2-pyridin-3-yl-propan-1-one DM8EDI7 MI TTIQUX7 DM8EDI7 MN Steroid 11-beta-hydroxylase (CYP11B1) DM8EDI7 MT DTT DM8EDI7 MA Inhibitor DM8EDI7 RN Structure-activity relationship study of the inhibition of adrenal cortical 11 beta-hydroxylase by new metyrapone analogues. J Med Chem. 1984 Jan;27(1):15-9. DM8EDI7 RU https://pubmed.ncbi.nlm.nih.gov/6606707 DM6QU5B DI DM6QU5B DM6QU5B DN 1-phenyl-3-(1,3,4-thiadiazol-2-yl)thiourea DM6QU5B MI TT6804T DM6QU5B MN MIF messenger RNA (MIF mRNA) DM6QU5B MT DTT DM6QU5B MA Inhibitor DM6QU5B RN An integrative in silico methodology for the identification of modulators of macrophage migration inhibitory factor (MIF) tautomerase activity. Bioorg Med Chem. 2010 Jul 15;18(14):5425-40. DM6QU5B RU https://pubmed.ncbi.nlm.nih.gov/20639113 DMCHOFK DI DMCHOFK DMCHOFK DN 1-Phenyl-3-(1-propionylpiperidin-4-yl)urea DMCHOFK MI TT7WVHI DMCHOFK MN Soluble epoxide hydrolase (EPHX2) DMCHOFK MT DTT DMCHOFK MA Inhibitor DMCHOFK RN 1-Aryl-3-(1-acylpiperidin-4-yl)urea inhibitors of human and murine soluble epoxide hydrolase: structure-activity relationships, pharmacokinetics, a... J Med Chem. 2010 Oct 14;53(19):7067-75. DMCHOFK RU https://pubmed.ncbi.nlm.nih.gov/20812725 DM9SKYC DI DM9SKYC DM9SKYC DN 1-phenyl-3-(2-(pyridin-2-yl)quinazolin-4-yl)urea DM9SKYC MI TTJFY5U DM9SKYC MN Adenosine A3 receptor (ADORA3) DM9SKYC MT DTT DM9SKYC MA Inhibitor DM9SKYC RN Pharmacophore based receptor modeling: the case of adenosine A3 receptor antagonists. An approach to the optimization of protein models. J Med Chem. 2006 Jul 13;49(14):4085-97. DM9SKYC RU https://pubmed.ncbi.nlm.nih.gov/16821770 DMQKB6W DI DMQKB6W DMQKB6W DN 1-phenyl-3-(2-(pyridin-3-yl)quinazolin-4-yl)urea DMQKB6W MI TTJFY5U DMQKB6W MN Adenosine A3 receptor (ADORA3) DMQKB6W MT DTT DMQKB6W MA Inhibitor DMQKB6W RN Pharmacophore based receptor modeling: the case of adenosine A3 receptor antagonists. An approach to the optimization of protein models. J Med Chem. 2006 Jul 13;49(14):4085-97. DMQKB6W RU https://pubmed.ncbi.nlm.nih.gov/16821770 DMJVITG DI DMJVITG DMJVITG DN 1-phenyl-3-(2-(pyridin-4-yl)thiazol-4-yl)urea DMJVITG MI TTL4Q97 DMJVITG MN Cyclin-dependent kinase 5 (CDK5) DMJVITG MT DTT DMJVITG MA Inhibitor DMJVITG RN Structure-activity relationships of 3,4-dihydro-1H-quinazolin-2-one derivatives as potential CDK5 inhibitors. Bioorg Med Chem. 2007 Oct 15;15(20):6574-95. DMJVITG RU https://pubmed.ncbi.nlm.nih.gov/17697781 DMJNAX5 DI DMJNAX5 DMJNAX5 DN 1-phenyl-3-(3-(pyridin-2-yl)isoquinolin-1-yl)urea DMJNAX5 MI TTJFY5U DMJNAX5 MN Adenosine A3 receptor (ADORA3) DMJNAX5 MT DTT DMJNAX5 MA Inhibitor DMJNAX5 RN Pharmacophore based receptor modeling: the case of adenosine A3 receptor antagonists. An approach to the optimization of protein models. J Med Chem. 2006 Jul 13;49(14):4085-97. DMJNAX5 RU https://pubmed.ncbi.nlm.nih.gov/16821770 DMJ723D DI DMJ723D DMJ723D DN 1-Phenyl-3-(4-pyridin-2-yl-thiazol-2-yl)-urea DMJ723D MI TTM2AOE DMJ723D MN Adenosine A2a receptor (ADORA2A) DMJ723D MT DTT DMJ723D MA Inhibitor DMJ723D RN Thiazole and thiadiazole analogues as a novel class of adenosine receptor antagonists. J Med Chem. 2001 Mar 1;44(5):749-62. DMJ723D RU https://pubmed.ncbi.nlm.nih.gov/11262085 DM8ZBHF DI DM8ZBHF DM8ZBHF DN 1-phenyl-3-(phenylsulfonyl)propan-1-one DM8ZBHF MI TTN7BL9 DM8ZBHF MN Corticosteroid 11-beta-dehydrogenase 1 (HSD11B1) DM8ZBHF MT DTT DM8ZBHF MA Inhibitor DM8ZBHF RN beta-Keto sulfones as inhibitors of 11beta-hydroxysteroid dehydrogenase type I and the mechanism of action. Bioorg Med Chem. 2007 Jul 1;15(13):4396-405. DM8ZBHF RU https://pubmed.ncbi.nlm.nih.gov/17490884 DMZOEQY DI DMZOEQY DMZOEQY DN 1-phenyl-3-(quinazolin-4-yl)urea DMZOEQY MI TTJFY5U DMZOEQY MN Adenosine A3 receptor (ADORA3) DMZOEQY MT DTT DMZOEQY MA Inhibitor DMZOEQY RN Pharmacophore based receptor modeling: the case of adenosine A3 receptor antagonists. An approach to the optimization of protein models. J Med Chem. 2006 Jul 13;49(14):4085-97. DMZOEQY RU https://pubmed.ncbi.nlm.nih.gov/16821770 DMUA72F DI DMUA72F DMUA72F DN 1-phenyl-3-aza-bicyclo[3.1.0]hexane DMUA72F MI TTVBI8W DMUA72F MN Dopamine transporter (DAT) DMUA72F MT DTT DMUA72F MA Inhibitor DMUA72F RN Studies on the structure-activity relationship of bicifadine analogs as monoamine transporter inhibitors. Bioorg Med Chem Lett. 2008 Jul 1;18(13):3682-6. DMUA72F RU https://pubmed.ncbi.nlm.nih.gov/18539031 DMUA72F DI DMUA72F DMUA72F DN 1-phenyl-3-aza-bicyclo[3.1.0]hexane DMUA72F MI TT3ROYC DMUA72F MN Serotonin transporter (SERT) DMUA72F MT DTT DMUA72F MA Inhibitor DMUA72F RN Studies on the structure-activity relationship of bicifadine analogs as monoamine transporter inhibitors. Bioorg Med Chem Lett. 2008 Jul 1;18(13):3682-6. DMUA72F RU https://pubmed.ncbi.nlm.nih.gov/18539031 DMKV17L DI DMKV17L DMKV17L DN 1-phenyl-4-(1-phenyl-1H-tetrazol-5-yl)butan-2-one DMKV17L MI TTN7BL9 DMKV17L MN Corticosteroid 11-beta-dehydrogenase 1 (HSD11B1) DMKV17L MT DTT DMKV17L MA Inhibitor DMKV17L RN Modulation of 11beta-hydroxysteroid dehydrogenase type 1 activity by 1,5-substituted 1H-tetrazoles. Bioorg Med Chem Lett. 2010 Jun 1;20(11):3265-71. DMKV17L RU https://pubmed.ncbi.nlm.nih.gov/20452767 DMA4XGL DI DMA4XGL DMA4XGL DN 1-phenylbiguanide DMA4XGL MI TTPC4TU DMA4XGL MN 5-HT 3A receptor (HTR3A) DMA4XGL MT DTT DMA4XGL MA Agonist DMA4XGL RN Allosteric interactions among agonists and antagonists at 5-hydroxytryptamine3 receptors. J Neurochem. 1995 Jul;65(1):104-10. DMA4XGL RU https://pubmed.ncbi.nlm.nih.gov/7790853 DMA4XGL DI DMA4XGL DMA4XGL DN 1-phenylbiguanide DMA4XGL MI TTR6K75 DMA4XGL MN 5-HT 3B receptor (HTR3B) DMA4XGL MT DTT DMA4XGL MA Agonist DMA4XGL RN Pharmacological comparison of human homomeric 5-HT3A receptors versus heteromeric 5-HT3A/3B receptors. Neuropharmacology. 2001 Aug;41(2):282-4. DMA4XGL RU https://pubmed.ncbi.nlm.nih.gov/11489465 DM04SWY DI DM04SWY DM04SWY DN 1-Phenyl-propane-1,2-dione DM04SWY MI TTMF541 DM04SWY MN Liver carboxylesterase (CES1) DM04SWY MT DTT DM04SWY MA Inhibitor DM04SWY RN Identification and characterization of novel benzil (diphenylethane-1,2-dione) analogues as inhibitors of mammalian carboxylesterases. J Med Chem. 2005 Apr 21;48(8):2906-15. DM04SWY RU https://pubmed.ncbi.nlm.nih.gov/15828829 DM5REQ9 DI DM5REQ9 DM5REQ9 DN 1-phenylthio-N,N-dimethyltryptamine DM5REQ9 MI TTJS8PY DM5REQ9 MN 5-HT 6 receptor (HTR6) DM5REQ9 MT DTT DM5REQ9 MA Inhibitor DM5REQ9 RN Binding of serotonin and N1-benzenesulfonyltryptamine-related analogs at human 5-HT6 serotonin receptors: receptor modeling studies. J Med Chem. 2008 Feb 14;51(3):603-11. DM5REQ9 RU https://pubmed.ncbi.nlm.nih.gov/18201064 DMCBX7R DI DMCBX7R DMCBX7R DN 1-Prop-2-ynyl-3,7-dihydro-purine-2,6-dione DMCBX7R MI TTJFY5U DMCBX7R MN Adenosine A3 receptor (ADORA3) DMCBX7R MT DTT DMCBX7R MA Inhibitor DMCBX7R RN Structure-activity relationships at human and rat A2B adenosine receptors of xanthine derivatives substituted at the 1-, 3-, 7-, and 8-positions. J Med Chem. 2002 May 23;45(11):2131-8. DMCBX7R RU https://pubmed.ncbi.nlm.nih.gov/12014951 DM1TNWG DI DM1TNWG DM1TNWG DN 1-propionyl-1H-indole-2,3-dione DM1TNWG MI TTMF541 DM1TNWG MN Liver carboxylesterase (CES1) DM1TNWG MT DTT DM1TNWG MA Inhibitor DM1TNWG RN Selective inhibition of carboxylesterases by isatins, indole-2,3-diones. J Med Chem. 2007 Apr 19;50(8):1876-85. DM1TNWG RU https://pubmed.ncbi.nlm.nih.gov/17378546 DMOCAUL DI DMOCAUL DMOCAUL DN 1-Propyl-3-(3-trifluoromethyl-phenyl)-pyrrolidine DMOCAUL MI TTSQIFT DMOCAUL MN 5-HT 1A receptor (HTR1A) DMOCAUL MT DTT DMOCAUL MA Inhibitor DMOCAUL RN Regioselective synthesis of 3-aryl substituted pyrrolidines via palladium catalyzed arylation: pharmacological evaluation for central dopaminergic and serotonergic activity, Bioorg. Med. Chem. Lett. 7(3):241-246 (1997). DMOCAUL RU http://www.sciencedirect.com/science/article/pii/S0960894X9600618X DMOCAUL DI DMOCAUL DMOCAUL DN 1-Propyl-3-(3-trifluoromethyl-phenyl)-pyrrolidine DMOCAUL MI TTJQOD7 DMOCAUL MN 5-HT 2A receptor (HTR2A) DMOCAUL MT DTT DMOCAUL MA Inhibitor DMOCAUL RN Regioselective synthesis of 3-aryl substituted pyrrolidines via palladium catalyzed arylation: pharmacological evaluation for central dopaminergic and serotonergic activity, Bioorg. Med. Chem. Lett. 7(3):241-246 (1997). DMOCAUL RU http://www.sciencedirect.com/science/article/pii/S0960894X9600618X DMOCAUL DI DMOCAUL DMOCAUL DN 1-Propyl-3-(3-trifluoromethyl-phenyl)-pyrrolidine DMOCAUL MI TTEX248 DMOCAUL MN Dopamine D2 receptor (D2R) DMOCAUL MT DTT DMOCAUL MA Inhibitor DMOCAUL RN Regioselective synthesis of 3-aryl substituted pyrrolidines via palladium catalyzed arylation: pharmacological evaluation for central dopaminergic and serotonergic activity, Bioorg. Med. Chem. Lett. 7(3):241-246 (1997). DMOCAUL RU http://www.sciencedirect.com/science/article/pii/S0960894X9600618X DMOCAUL DI DMOCAUL DMOCAUL DN 1-Propyl-3-(3-trifluoromethyl-phenyl)-pyrrolidine DMOCAUL MI TT4C8EA DMOCAUL MN Dopamine D3 receptor (D3R) DMOCAUL MT DTT DMOCAUL MA Inhibitor DMOCAUL RN Regioselective synthesis of 3-aryl substituted pyrrolidines via palladium catalyzed arylation: pharmacological evaluation for central dopaminergic and serotonergic activity, Bioorg. Med. Chem. Lett. 7(3):241-246 (1997). DMOCAUL RU http://www.sciencedirect.com/science/article/pii/S0960894X9600618X DML5J94 DI DML5J94 DML5J94 DN 1-Propyl-3,7-dihydro-purine-2,6-dione DML5J94 MI TTK25J1 DML5J94 MN Adenosine A1 receptor (ADORA1) DML5J94 MT DTT DML5J94 MA Inhibitor DML5J94 RN Structure-activity relationships at human and rat A2B adenosine receptors of xanthine derivatives substituted at the 1-, 3-, 7-, and 8-positions. J Med Chem. 2002 May 23;45(11):2131-8. DML5J94 RU https://pubmed.ncbi.nlm.nih.gov/12014951 DML5J94 DI DML5J94 DML5J94 DN 1-Propyl-3,7-dihydro-purine-2,6-dione DML5J94 MI TTNE7KG DML5J94 MN Adenosine A2b receptor (ADORA2B) DML5J94 MT DTT DML5J94 MA Inhibitor DML5J94 RN Structure-activity relationships at human and rat A2B adenosine receptors of xanthine derivatives substituted at the 1-, 3-, 7-, and 8-positions. J Med Chem. 2002 May 23;45(11):2131-8. DML5J94 RU https://pubmed.ncbi.nlm.nih.gov/12014951 DML5J94 DI DML5J94 DML5J94 DN 1-Propyl-3,7-dihydro-purine-2,6-dione DML5J94 MI TTJFY5U DML5J94 MN Adenosine A3 receptor (ADORA3) DML5J94 MT DTT DML5J94 MA Inhibitor DML5J94 RN Structure-activity relationships at human and rat A2B adenosine receptors of xanthine derivatives substituted at the 1-, 3-, 7-, and 8-positions. J Med Chem. 2002 May 23;45(11):2131-8. DML5J94 RU https://pubmed.ncbi.nlm.nih.gov/12014951 DM1387P DI DM1387P DM1387P DN 1-Propyl-3-m-tolyl-piperidine hydrochloride DM1387P MI TTEX248 DM1387P MN Dopamine D2 receptor (D2R) DM1387P MT DTT DM1387P MA Inhibitor DM1387P RN New N-n-propyl-substituted 3-aryl- and 3-cyclohexylpiperidines as partial agonists at the D4 dopamine receptor. J Med Chem. 2003 Jan 2;46(1):161-8. DM1387P RU https://pubmed.ncbi.nlm.nih.gov/12502370 DM1O6KQ DI DM1O6KQ DM1O6KQ DN 1-Propyl-3-o-tolyl-piperidine hydrochloride DM1O6KQ MI TTEX248 DM1O6KQ MN Dopamine D2 receptor (D2R) DM1O6KQ MT DTT DM1O6KQ MA Inhibitor DM1O6KQ RN New N-n-propyl-substituted 3-aryl- and 3-cyclohexylpiperidines as partial agonists at the D4 dopamine receptor. J Med Chem. 2003 Jan 2;46(1):161-8. DM1O6KQ RU https://pubmed.ncbi.nlm.nih.gov/12502370 DMPMIN9 DI DMPMIN9 DMPMIN9 DN 1-Propyl-3-p-tolyl-piperidine hydrochloride DMPMIN9 MI TTEX248 DMPMIN9 MN Dopamine D2 receptor (D2R) DMPMIN9 MT DTT DMPMIN9 MA Inhibitor DMPMIN9 RN New N-n-propyl-substituted 3-aryl- and 3-cyclohexylpiperidines as partial agonists at the D4 dopamine receptor. J Med Chem. 2003 Jan 2;46(1):161-8. DMPMIN9 RU https://pubmed.ncbi.nlm.nih.gov/12502370 DM5P01L DI DM5P01L DM5P01L DN 1-propyl-5'-O-tritylinosine DM5P01L MI TTO0IB8 DM5P01L MN Thymidine phosphorylase (TYMP) DM5P01L MT DTT DM5P01L MA Inhibitor DM5P01L RN 5'-O-tritylinosine and analogues as allosteric inhibitors of human thymidine phosphorylase. J Med Chem. 2006 Sep 7;49(18):5562-70. DM5P01L RU https://pubmed.ncbi.nlm.nih.gov/16942029 DMXOUFI DI DMXOUFI DMXOUFI DN 1-Propylidenethiosemicarbazide DMXOUFI MI TTULVH8 DMXOUFI MN Tyrosinase (TYR) DMXOUFI MT DTT DMXOUFI MA Inhibitor DMXOUFI RN A class of potent tyrosinase inhibitors: alkylidenethiosemicarbazide compounds. Eur J Med Chem. 2009 Apr;44(4):1773-8. DMXOUFI RU https://pubmed.ncbi.nlm.nih.gov/18524420 DMTMXN4 DI DMTMXN4 DMTMXN4 DN 1-Pyridin-2-yl-3-quinolin-5-yl-urea DMTMXN4 MI TT0PG8F DMTMXN4 MN Cyclin-dependent kinase 4 (CDK4) DMTMXN4 MT DTT DMTMXN4 MA Inhibitor DMTMXN4 RN Structure-based generation of a new class of potent Cdk4 inhibitors: new de novo design strategy and library design. J Med Chem. 2001 Dec 20;44(26):4615-27. DMTMXN4 RU https://pubmed.ncbi.nlm.nih.gov/11741479 DM7Y5AN DI DM7Y5AN DM7Y5AN DN 1S,2R-milnacipran DM7Y5AN MI TTVBI8W DM7Y5AN MN Dopamine transporter (DAT) DM7Y5AN MT DTT DM7Y5AN MA Inhibitor DM7Y5AN RN Characterization of thien-2-yl 1S,2R-milnacipran analogues as potent norepinephrine/serotonin transporter inhibitors for the treatment of neuropath... J Med Chem. 2008 Nov 27;51(22):7265-72. DM7Y5AN RU https://pubmed.ncbi.nlm.nih.gov/18954038 DM7Y5AN DI DM7Y5AN DM7Y5AN DN 1S,2R-milnacipran DM7Y5AN MI TTAWNKZ DM7Y5AN MN Norepinephrine transporter (NET) DM7Y5AN MT DTT DM7Y5AN MA Inhibitor DM7Y5AN RN Characterization of thien-2-yl 1S,2R-milnacipran analogues as potent norepinephrine/serotonin transporter inhibitors for the treatment of neuropath... J Med Chem. 2008 Nov 27;51(22):7265-72. DM7Y5AN RU https://pubmed.ncbi.nlm.nih.gov/18954038 DM7Y5AN DI DM7Y5AN DM7Y5AN DN 1S,2R-milnacipran DM7Y5AN MI TT3ROYC DM7Y5AN MN Serotonin transporter (SERT) DM7Y5AN MT DTT DM7Y5AN MA Inhibitor DM7Y5AN RN Characterization of thien-2-yl 1S,2R-milnacipran analogues as potent norepinephrine/serotonin transporter inhibitors for the treatment of neuropath... J Med Chem. 2008 Nov 27;51(22):7265-72. DM7Y5AN RU https://pubmed.ncbi.nlm.nih.gov/18954038 DM7K0B3 DI DM7K0B3 DM7K0B3 DN 1-stearoyl-lysophosphatidylcholine DM7K0B3 MI TT7QNVC DM7K0B3 MN Glucose-dependent insulinotropic receptor (GPR119) DM7K0B3 MT DTT DM7K0B3 MA Agonist DM7K0B3 RN Lysophosphatidylcholine enhances glucose-dependent insulin secretion via an orphan G-protein-coupled receptor. Biochem Biophys Res Commun. 2005 Jan 28;326(4):744-51. DM7K0B3 RU https://pubmed.ncbi.nlm.nih.gov/15607732 DMPSM4O DI DMPSM4O DMPSM4O DN 1-tert-butyl-9H-carbazole DMPSM4O MI TTBGTCW DMPSM4O MN Kinesin spindle messenger RNA (KIF11 mRNA) DMPSM4O MT DTT DMPSM4O MA Inhibitor DMPSM4O RN Kinesin spindle protein (KSP) inhibitors with 2,3-fused indole scaffolds. J Med Chem. 2010 Jul 8;53(13):5054-8. DMPSM4O RU https://pubmed.ncbi.nlm.nih.gov/20521839 DMAQKO1 DI DMAQKO1 DMAQKO1 DN 1-Thiazol-2-yl-3-(2-o-tolyl-ethyl)-thiourea DMAQKO1 MI TT84ETX DMAQKO1 MN Human immunodeficiency virus Reverse transcriptase (HIV RT) DMAQKO1 MT DTT DMAQKO1 MA Inhibitor DMAQKO1 RN Phenethylthiazolethiourea (PETT) compounds, a new class of HIV-1 reverse transcriptase inhibitors. 1. Synthesis and basic structure-activity relati... J Med Chem. 1995 Dec 8;38(25):4929-36. DMAQKO1 RU https://pubmed.ncbi.nlm.nih.gov/8523406 DMCIA40 DI DMCIA40 DMCIA40 DN 1-Thiazol-2-yl-3-(2-p-tolyl-ethyl)-thiourea DMCIA40 MI TT84ETX DMCIA40 MN Human immunodeficiency virus Reverse transcriptase (HIV RT) DMCIA40 MT DTT DMCIA40 MA Inhibitor DMCIA40 RN Anti-HIV activity of aromatic and heterocyclic thiazolyl thiourea compounds. Bioorg Med Chem Lett. 2001 Feb 26;11(4):523-8. DMCIA40 RU https://pubmed.ncbi.nlm.nih.gov/11229762 DM9SYEP DI DM9SYEP DM9SYEP DN 1'-tosylspiro[indene-1,4'-piperidine] DM9SYEP MI TTSCIUP DM9SYEP MN Oxytocin receptor (OTR) DM9SYEP MT DTT DM9SYEP MA Inhibitor DM9SYEP RN Oral oxytocin antagonists. J Med Chem. 2010 Sep 23;53(18):6525-38. DM9SYEP RU https://pubmed.ncbi.nlm.nih.gov/20550119 DM9SYEP DI DM9SYEP DM9SYEP DN 1'-tosylspiro[indene-1,4'-piperidine] DM9SYEP MI TT4TFGN DM9SYEP MN Vasopressin V1a receptor (V1AR) DM9SYEP MT DTT DM9SYEP MA Inhibitor DM9SYEP RN Oral oxytocin antagonists. J Med Chem. 2010 Sep 23;53(18):6525-38. DM9SYEP RU https://pubmed.ncbi.nlm.nih.gov/20550119 DM9ZRU2 DI DM9ZRU2 DM9ZRU2 DN 1-valproylamido-5-sulfonamidoindane DM9ZRU2 MI TTHQPL7 DM9ZRU2 MN Carbonic anhydrase I (CA-I) DM9ZRU2 MT DTT DM9ZRU2 MA Inhibitor DM9ZRU2 RN Indanesulfonamides as carbonic anhydrase inhibitors. Toward structure-based design of selective inhibitors of the tumor-associated isozyme CA IX. J Med Chem. 2006 May 4;49(9):2743-9. DM9ZRU2 RU https://pubmed.ncbi.nlm.nih.gov/16640335 DM9ZRU2 DI DM9ZRU2 DM9ZRU2 DN 1-valproylamido-5-sulfonamidoindane DM9ZRU2 MI TTANPDJ DM9ZRU2 MN Carbonic anhydrase II (CA-II) DM9ZRU2 MT DTT DM9ZRU2 MA Inhibitor DM9ZRU2 RN Indanesulfonamides as carbonic anhydrase inhibitors. Toward structure-based design of selective inhibitors of the tumor-associated isozyme CA IX. J Med Chem. 2006 May 4;49(9):2743-9. DM9ZRU2 RU https://pubmed.ncbi.nlm.nih.gov/16640335 DM9ZRU2 DI DM9ZRU2 DM9ZRU2 DN 1-valproylamido-5-sulfonamidoindane DM9ZRU2 MI TT2LVK8 DM9ZRU2 MN Carbonic anhydrase IX (CA-IX) DM9ZRU2 MT DTT DM9ZRU2 MA Inhibitor DM9ZRU2 RN Indanesulfonamides as carbonic anhydrase inhibitors. Toward structure-based design of selective inhibitors of the tumor-associated isozyme CA IX. J Med Chem. 2006 May 4;49(9):2743-9. DM9ZRU2 RU https://pubmed.ncbi.nlm.nih.gov/16640335 DM1TK45 DI DM1TK45 DM1TK45 DN 2-((1H-imidazol-4-yl)methyl)pyridine DM1TK45 MI TT9JNIC DM1TK45 MN Histamine H3 receptor (H3R) DM1TK45 MT DTT DM1TK45 MA Inhibitor DM1TK45 RN Investigation of the histamine H3 receptor binding site. Design and synthesis of hybrid agonists with a lipophilic side chain. J Med Chem. 2010 Sep 9;53(17):6445-56. DM1TK45 RU https://pubmed.ncbi.nlm.nih.gov/20690643 DM91PA5 DI DM91PA5 DM91PA5 DN 2-((2-ethoxyphenoxy)methyl)-4-isopropylmorpholine DM91PA5 MI TT9JNIC DM91PA5 MN Histamine H3 receptor (H3R) DM91PA5 MT DTT DM91PA5 MA Inhibitor DM91PA5 RN 2-Aryloxymethylmorpholine histamine H(3) antagonists. Bioorg Med Chem Lett. 2008 Nov 1;18(21):5796-9. DM91PA5 RU https://pubmed.ncbi.nlm.nih.gov/18922693 DMS1AOK DI DMS1AOK DMS1AOK DN 2-((2-iodophenoxy)(phenyl)methyl)morpholine DMS1AOK MI TTVBI8W DMS1AOK MN Dopamine transporter (DAT) DMS1AOK MT DTT DMS1AOK MA Inhibitor DMS1AOK RN Development of SPECT imaging agents for the norepinephrine transporters: [123I]INER. Bioorg Med Chem Lett. 2007 Jan 15;17(2):533-7. DMS1AOK RU https://pubmed.ncbi.nlm.nih.gov/17095215 DMS1AOK DI DMS1AOK DMS1AOK DN 2-((2-iodophenoxy)(phenyl)methyl)morpholine DMS1AOK MI TTAWNKZ DMS1AOK MN Norepinephrine transporter (NET) DMS1AOK MT DTT DMS1AOK MA Inhibitor DMS1AOK RN Development of SPECT imaging agents for the norepinephrine transporters: [123I]INER. Bioorg Med Chem Lett. 2007 Jan 15;17(2):533-7. DMS1AOK RU https://pubmed.ncbi.nlm.nih.gov/17095215 DM1BI65 DI DM1BI65 DM1BI65 DN 2-((3,5-diamino-1H-pyrazol-4-yl)diazenyl)phenol DM1BI65 MI TT7HF4W DM1BI65 MN Cyclin-dependent kinase 2 (CDK2) DM1BI65 MT DTT DM1BI65 MA Inhibitor DM1BI65 RN 4-arylazo-3,5-diamino-1H-pyrazole CDK inhibitors: SAR study, crystal structure in complex with CDK2, selectivity, and cellular effects. J Med Chem. 2006 Nov 2;49(22):6500-9. DM1BI65 RU https://pubmed.ncbi.nlm.nih.gov/17064068 DM1BI65 DI DM1BI65 DM1BI65 DN 2-((3,5-diamino-1H-pyrazol-4-yl)diazenyl)phenol DM1BI65 MI TTCEJ4F DM1BI65 MN G1/S-specific cyclin-E1 (CCNE1) DM1BI65 MT DTT DM1BI65 MA Inhibitor DM1BI65 RN 4-arylazo-3,5-diamino-1H-pyrazole CDK inhibitors: SAR study, crystal structure in complex with CDK2, selectivity, and cellular effects. J Med Chem. 2006 Nov 2;49(22):6500-9. DM1BI65 RU https://pubmed.ncbi.nlm.nih.gov/17064068 DMS21CR DI DMS21CR DMS21CR DN 2-((3-iodophenyl)(o-tolyloxy)methyl)morpholine DMS21CR MI TTVBI8W DMS21CR MN Dopamine transporter (DAT) DMS21CR MT DTT DMS21CR MA Inhibitor DMS21CR RN Development of SPECT imaging agents for the norepinephrine transporters: [123I]INER. Bioorg Med Chem Lett. 2007 Jan 15;17(2):533-7. DMS21CR RU https://pubmed.ncbi.nlm.nih.gov/17095215 DMS21CR DI DMS21CR DMS21CR DN 2-((3-iodophenyl)(o-tolyloxy)methyl)morpholine DMS21CR MI TTAWNKZ DMS21CR MN Norepinephrine transporter (NET) DMS21CR MT DTT DMS21CR MA Inhibitor DMS21CR RN Development of SPECT imaging agents for the norepinephrine transporters: [123I]INER. Bioorg Med Chem Lett. 2007 Jan 15;17(2):533-7. DMS21CR RU https://pubmed.ncbi.nlm.nih.gov/17095215 DMFXDY3 DI DMFXDY3 DMFXDY3 DN 2-(1-(aminomethyl)-3-butylcyclopentyl)acetic acid DMFXDY3 MI TTFK1JQ DMFXDY3 MN Voltage-gated calcium channel alpha-2/delta-1 (CACNA2D1) DMFXDY3 MT DTT DMFXDY3 MA Inhibitor DMFXDY3 RN Synthesis and in vivo evaluation of 3-substituted gababutins. Bioorg Med Chem Lett. 2010 Jan 1;20(1):362-5. DMFXDY3 RU https://pubmed.ncbi.nlm.nih.gov/19897364 DM1ASK6 DI DM1ASK6 DM1ASK6 DN 2-(1-(aminomethyl)-3-ethylcyclopentyl)acetic acid DM1ASK6 MI TTFK1JQ DM1ASK6 MN Voltage-gated calcium channel alpha-2/delta-1 (CACNA2D1) DM1ASK6 MT DTT DM1ASK6 MA Inhibitor DM1ASK6 RN Synthesis and in vivo evaluation of 3-substituted gababutins. Bioorg Med Chem Lett. 2010 Jan 1;20(1):362-5. DM1ASK6 RU https://pubmed.ncbi.nlm.nih.gov/19897364 DM3D8WI DI DM3D8WI DM3D8WI DN 2-(1-(phenylsulfonyl)-1H-indol-3-yl)ethanamine DM3D8WI MI TTJS8PY DM3D8WI MN 5-HT 6 receptor (HTR6) DM3D8WI MT DTT DM3D8WI MA Inhibitor DM3D8WI RN Discovery of N1-(6-chloroimidazo[2,1-b][1,3]thiazole-5-sulfonyl)tryptamine as a potent, selective, and orally active 5-HT(6) receptor agonist. J Med Chem. 2007 Nov 15;50(23):5535-8. DM3D8WI RU https://pubmed.ncbi.nlm.nih.gov/17948978 DMUE0D6 DI DMUE0D6 DMUE0D6 DN 2-(1,1'-Biphenyl-4-Yl)Propanoic Acid DMUE0D6 MI TT8NGED DMUE0D6 MN Prostaglandin G/H synthase 1 (COX-1) DMUE0D6 MT DTT DMUE0D6 MA Inhibitor DMUE0D6 RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DMUE0D6 RU https://pubmed.ncbi.nlm.nih.gov/10592235 DMZ83G9 DI DMZ83G9 DMZ83G9 DN 2-(1,4'-bipiperidin-1'-yl)thiazolo[4,5-b]pyridine DMZ83G9 MI TT9JNIC DMZ83G9 MN Histamine H3 receptor (H3R) DMZ83G9 MT DTT DMZ83G9 MA Inhibitor DMZ83G9 RN Synthesis and structure-activity relationships of 2-(1,4'-bipiperidin-1'-yl)thiazolopyridine as H3 receptor antagonists. Bioorg Med Chem Lett. 2009 Nov 1;19(21):6176-80. DMZ83G9 RU https://pubmed.ncbi.nlm.nih.gov/19773164 DMEKSAZ DI DMEKSAZ DMEKSAZ DN 2-(1,4'-bipiperidin-1'-yl)thiazolo[4,5-c]pyridine DMEKSAZ MI TT9JNIC DMEKSAZ MN Histamine H3 receptor (H3R) DMEKSAZ MT DTT DMEKSAZ MA Inhibitor DMEKSAZ RN Synthesis and structure-activity relationships of 2-(1,4'-bipiperidin-1'-yl)thiazolopyridine as H3 receptor antagonists. Bioorg Med Chem Lett. 2009 Nov 1;19(21):6176-80. DMEKSAZ RU https://pubmed.ncbi.nlm.nih.gov/19773164 DMVXN01 DI DMVXN01 DMVXN01 DN 2-(10-Imidazol-1-yl-decyl)-isoindole-1,3-dione DMVXN01 MI TTKNWZ4 DMVXN01 MN Thromboxane-A synthase (TBXAS1) DMVXN01 MT DTT DMVXN01 MA Inhibitor DMVXN01 RN Thromboxane synthetase inhibitors and antihypertensive agents. 2. N-[(1H-imidazol-1-yl)alkyl]-1H-isoindole-1,3(2H)-diones and N-[(1H-1,2,4-triazol-... J Med Chem. 1986 May;29(5):816-9. DMVXN01 RU https://pubmed.ncbi.nlm.nih.gov/3517332 DM05OJD DI DM05OJD DM05OJD DN 2-(1-adamantyl) piperidine DM05OJD MI TTXT3PU DM05OJD MN Influenza M2 protein (Influ M) DM05OJD MT DTT DM05OJD MA Inhibitor DM05OJD RN Antiviral agents active against influenza A viruses. Nat Rev Drug Discov. 2006 Dec;5(12):1015-25. DM05OJD RU https://pubmed.ncbi.nlm.nih.gov/17139286 DMMSFEU DI DMMSFEU DMMSFEU DN 2-(1-adamantyl) pyrrolidine DMMSFEU MI TTXT3PU DMMSFEU MN Influenza M2 protein (Influ M) DMMSFEU MT DTT DMMSFEU MA Inhibitor DMMSFEU RN Antiviral agents active against influenza A viruses. Nat Rev Drug Discov. 2006 Dec;5(12):1015-25. DMMSFEU RU https://pubmed.ncbi.nlm.nih.gov/17139286 DMIGRMV DI DMIGRMV DMIGRMV DN 2-(1-adamantyl)-2-methyl-pyrrolidine DMIGRMV MI TTXT3PU DMIGRMV MN Influenza M2 protein (Influ M) DMIGRMV MT DTT DMIGRMV MA Inhibitor DMIGRMV RN Antiviral agents active against influenza A viruses. Nat Rev Drug Discov. 2006 Dec;5(12):1015-25. DMIGRMV RU https://pubmed.ncbi.nlm.nih.gov/17139286 DMB5LHA DI DMB5LHA DMB5LHA DN 2-(1-benzyl-1H-inden-3-yl)-N,N-dimethylethanamine DMB5LHA MI TTJS8PY DMB5LHA MN 5-HT 6 receptor (HTR6) DMB5LHA MT DTT DMB5LHA MA Inhibitor DMB5LHA RN Indene-based scaffolds. 2. An indole-indene switch: discovery of novel indenylsulfonamides as 5-HT6 serotonin receptor agonists. J Med Chem. 2009 Feb 12;52(3):675-87. DMB5LHA RU https://pubmed.ncbi.nlm.nih.gov/19159187 DMML3XI DI DMML3XI DMML3XI DN 2-(1-benzyl-1H-indol-3-yl)-N,N-dimethylethanamine DMML3XI MI TTJS8PY DMML3XI MN 5-HT 6 receptor (HTR6) DMML3XI MT DTT DMML3XI MA Inhibitor DMML3XI RN Indene-based scaffolds. 2. An indole-indene switch: discovery of novel indenylsulfonamides as 5-HT6 serotonin receptor agonists. J Med Chem. 2009 Feb 12;52(3):675-87. DMML3XI RU https://pubmed.ncbi.nlm.nih.gov/19159187 DMF2XHZ DI DMF2XHZ DMF2XHZ DN 2-(1-dodecyl-1H-indol-3-yl)acetic acid DMF2XHZ MI TTLZS4Q DMF2XHZ MN M-phase inducer phosphatase 1 (MPIP1) DMF2XHZ MT DTT DMF2XHZ MA Inhibitor DMF2XHZ RN Design and synthesis of N-alkyl oxindolylidene acetic acids as a new class of potent Cdc25A inhibitors. Bioorg Med Chem Lett. 2008 Jun 1;18(11):3350-3. DMF2XHZ RU https://pubmed.ncbi.nlm.nih.gov/18442908 DM0Y2P1 DI DM0Y2P1 DM0Y2P1 DN 2-(1H-benzo[d]imidazol-2-yl)quinoxaline DM0Y2P1 MI TTK25J1 DM0Y2P1 MN Adenosine A1 receptor (ADORA1) DM0Y2P1 MT DTT DM0Y2P1 MA Inhibitor DM0Y2P1 RN Derivatives of 4-amino-6-hydroxy-2-mercaptopyrimidine as novel, potent, and selective A3 adenosine receptor antagonists. J Med Chem. 2008 Mar 27;51(6):1764-70. DM0Y2P1 RU https://pubmed.ncbi.nlm.nih.gov/18269230 DM0Y2P1 DI DM0Y2P1 DM0Y2P1 DN 2-(1H-benzo[d]imidazol-2-yl)quinoxaline DM0Y2P1 MI TTM2AOE DM0Y2P1 MN Adenosine A2a receptor (ADORA2A) DM0Y2P1 MT DTT DM0Y2P1 MA Inhibitor DM0Y2P1 RN Derivatives of 4-amino-6-hydroxy-2-mercaptopyrimidine as novel, potent, and selective A3 adenosine receptor antagonists. J Med Chem. 2008 Mar 27;51(6):1764-70. DM0Y2P1 RU https://pubmed.ncbi.nlm.nih.gov/18269230 DM0Y2P1 DI DM0Y2P1 DM0Y2P1 DN 2-(1H-benzo[d]imidazol-2-yl)quinoxaline DM0Y2P1 MI TTJFY5U DM0Y2P1 MN Adenosine A3 receptor (ADORA3) DM0Y2P1 MT DTT DM0Y2P1 MA Inhibitor DM0Y2P1 RN Derivatives of 4-amino-6-hydroxy-2-mercaptopyrimidine as novel, potent, and selective A3 adenosine receptor antagonists. J Med Chem. 2008 Mar 27;51(6):1764-70. DM0Y2P1 RU https://pubmed.ncbi.nlm.nih.gov/18269230 DMXA20E DI DMXA20E DMXA20E DN 2-(1H-imidazo[4,5-c]pyridin-2-yl)quinoxaline DMXA20E MI TTJFY5U DMXA20E MN Adenosine A3 receptor (ADORA3) DMXA20E MT DTT DMXA20E MA Inhibitor DMXA20E RN 2-(Benzimidazol-2-yl)quinoxalines: a novel class of selective antagonists at human A(1) and A(3) adenosine receptors designed by 3D database search... J Med Chem. 2005 Dec 29;48(26):8253-60. DMXA20E RU https://pubmed.ncbi.nlm.nih.gov/16366607 DMFK9GA DI DMFK9GA DMFK9GA DN 2-(1H-Imidazol-1-yl)-1-(4-nitrophenyl)ethanone DMFK9GA MI TTSZLWK DMFK9GA MN Aromatase (CYP19A1) DMFK9GA MT DTT DMFK9GA MA Inhibitor DMFK9GA RN Design, synthesis, and biological evaluation of resveratrol analogues as aromatase and quinone reductase 2 inhibitors for chemoprevention of cancer. Bioorg Med Chem. 2010 Jul 15;18(14):5352-66. DMFK9GA RU https://pubmed.ncbi.nlm.nih.gov/20558073 DM2PZ1B DI DM2PZ1B DM2PZ1B DN 2-(1H-Imidazol-4-yl)benzene-1,3-diol DM2PZ1B MI TTZJYKH DM2PZ1B MN Indoleamine 2,3-dioxygenase 1 (IDO1) DM2PZ1B MT DTT DM2PZ1B MA Inhibitor DM2PZ1B RN Structure based development of phenylimidazole-derived inhibitors of indoleamine 2,3-dioxygenase. J Med Chem. 2008 Aug 28;51(16):4968-77. DM2PZ1B RU https://pubmed.ncbi.nlm.nih.gov/18665584 DM6MR82 DI DM6MR82 DM6MR82 DN 2-(1H-Imidazol-4-yl)phenol DM6MR82 MI TTZJYKH DM6MR82 MN Indoleamine 2,3-dioxygenase 1 (IDO1) DM6MR82 MT DTT DM6MR82 MA Inhibitor DM6MR82 RN Structure based development of phenylimidazole-derived inhibitors of indoleamine 2,3-dioxygenase. J Med Chem. 2008 Aug 28;51(16):4968-77. DM6MR82 RU https://pubmed.ncbi.nlm.nih.gov/18665584 DMCG1HE DI DMCG1HE DMCG1HE DN 2-(1H-Imidazol-4-ylmethyl)-4-phenyl-thiazole DMCG1HE MI TTPC4TU DMCG1HE MN 5-HT 3A receptor (HTR3A) DMCG1HE MT DTT DMCG1HE MA Inhibitor DMCG1HE RN Aromatic thiazole derivatives: structurally novel and selective serotonin-3 receptor antagonists. J Med Chem. 1990 Jan;33(1):13-6. DMCG1HE RU https://pubmed.ncbi.nlm.nih.gov/2296012 DMCG1HE DI DMCG1HE DMCG1HE DN 2-(1H-Imidazol-4-ylmethyl)-4-phenyl-thiazole DMCG1HE MI TTR6K75 DMCG1HE MN 5-HT 3B receptor (HTR3B) DMCG1HE MT DTT DMCG1HE MA Inhibitor DMCG1HE RN Aromatic thiazole derivatives: structurally novel and selective serotonin-3 receptor antagonists. J Med Chem. 1990 Jan;33(1):13-6. DMCG1HE RU https://pubmed.ncbi.nlm.nih.gov/2296012 DM0CSH8 DI DM0CSH8 DM0CSH8 DN 2-(1H-indazol-3-yl)-1H-benzo[d]imidazole DM0CSH8 MI TTTU902 DM0CSH8 MN Checkpoint kinase-1 (CHK1) DM0CSH8 MT DTT DM0CSH8 MA Inhibitor DM0CSH8 RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DM0CSH8 RU https://pubmed.ncbi.nlm.nih.gov/10592235 DM0CSH8 DI DM0CSH8 DM0CSH8 DN 2-(1H-indazol-3-yl)-1H-benzo[d]imidazole DM0CSH8 MI TTRLW2X DM0CSH8 MN Fibroblast growth factor receptor 1 (FGFR1) DM0CSH8 MT DTT DM0CSH8 MA Inhibitor DM0CSH8 RN Design and structure-activity relationship of 3-benzimidazol-2-yl-1H-indazoles as inhibitors of receptor tyrosine kinases. Bioorg Med Chem Lett. 2006 Jul 1;16(13):3595-9. DM0CSH8 RU https://pubmed.ncbi.nlm.nih.gov/16603352 DM0CSH8 DI DM0CSH8 DM0CSH8 DN 2-(1H-indazol-3-yl)-1H-benzo[d]imidazole DM0CSH8 MI TTI7421 DM0CSH8 MN Platelet-derived growth factor receptor beta (PDGFRB) DM0CSH8 MT DTT DM0CSH8 MA Inhibitor DM0CSH8 RN Design and structure-activity relationship of 3-benzimidazol-2-yl-1H-indazoles as inhibitors of receptor tyrosine kinases. Bioorg Med Chem Lett. 2006 Jul 1;16(13):3595-9. DM0CSH8 RU https://pubmed.ncbi.nlm.nih.gov/16603352 DM0CSH8 DI DM0CSH8 DM0CSH8 DN 2-(1H-indazol-3-yl)-1H-benzo[d]imidazole DM0CSH8 MI TTUTJGQ DM0CSH8 MN Vascular endothelial growth factor receptor 2 (KDR) DM0CSH8 MT DTT DM0CSH8 MA Inhibitor DM0CSH8 RN Design and structure-activity relationship of 3-benzimidazol-2-yl-1H-indazoles as inhibitors of receptor tyrosine kinases. Bioorg Med Chem Lett. 2006 Jul 1;16(13):3595-9. DM0CSH8 RU https://pubmed.ncbi.nlm.nih.gov/16603352 DM0CSH8 DI DM0CSH8 DM0CSH8 DN 2-(1H-indazol-3-yl)-1H-benzo[d]imidazole DM0CSH8 MI TT1VAUK DM0CSH8 MN VEGFR1 messenger RNA (VEGFR1 mRNA) DM0CSH8 MT DTT DM0CSH8 MA Inhibitor DM0CSH8 RN Design and structure-activity relationship of 3-benzimidazol-2-yl-1H-indazoles as inhibitors of receptor tyrosine kinases. Bioorg Med Chem Lett. 2006 Jul 1;16(13):3595-9. DM0CSH8 RU https://pubmed.ncbi.nlm.nih.gov/16603352 DMFAME4 DI DMFAME4 DMFAME4 DN 2-(1H-Indol-3-yl)-2-oxo-N-phenethyl-acetamide DMFAME4 MI TT1MPAY DMFAME4 MN GABA(A) receptor alpha-1 (GABRA1) DMFAME4 MT DTT DMFAME4 MA Inhibitor DMFAME4 RN Benzodiazepine receptor affinity and interaction of some N-(indol-3-ylglyoxylyl)amine derivatives. J Med Chem. 1992 Jun 12;35(12):2214-20. DMFAME4 RU https://pubmed.ncbi.nlm.nih.gov/1319492 DMFAME4 DI DMFAME4 DMFAME4 DN 2-(1H-Indol-3-yl)-2-oxo-N-phenethyl-acetamide DMFAME4 MI TT06RH5 DMFAME4 MN GABA(A) receptor gamma-2 (GABRG2) DMFAME4 MT DTT DMFAME4 MA Inhibitor DMFAME4 RN Benzodiazepine receptor affinity and interaction of some N-(indol-3-ylglyoxylyl)amine derivatives. J Med Chem. 1992 Jun 12;35(12):2214-20. DMFAME4 RU https://pubmed.ncbi.nlm.nih.gov/1319492 DMFAME4 DI DMFAME4 DMFAME4 DN 2-(1H-Indol-3-yl)-2-oxo-N-phenethyl-acetamide DMFAME4 MI TTNJYV2 DMFAME4 MN Gamma-aminobutyric acid receptor (GAR) DMFAME4 MT DTT DMFAME4 MA Inhibitor DMFAME4 RN Benzodiazepine receptor affinity and interaction of some N-(indol-3-ylglyoxylyl)amine derivatives. J Med Chem. 1992 Jun 12;35(12):2214-20. DMFAME4 RU https://pubmed.ncbi.nlm.nih.gov/1319492 DMR9Q4Y DI DMR9Q4Y DMR9Q4Y DN 2-(1H-indol-3-yl)-N,N-dimethylethanamine DMR9Q4Y MI TTJQOD7 DMR9Q4Y MN 5-HT 2A receptor (HTR2A) DMR9Q4Y MT DTT DMR9Q4Y MA Inhibitor DMR9Q4Y RN Dose-response study of N,N-dimethyltryptamine in humans. I. Neuroendocrine, autonomic, and cardiovascular effects. Arch Gen Psychiatry. 1994 Feb;51(2):85-97. DMR9Q4Y RU https://pubmed.ncbi.nlm.nih.gov/8297216 DMR9Q4Y DI DMR9Q4Y DMR9Q4Y DN 2-(1H-indol-3-yl)-N,N-dimethylethanamine DMR9Q4Y MI TTJS8PY DMR9Q4Y MN 5-HT 6 receptor (HTR6) DMR9Q4Y MT DTT DMR9Q4Y MA Inhibitor DMR9Q4Y RN Dose-response study of N,N-dimethyltryptamine in humans. I. Neuroendocrine, autonomic, and cardiovascular effects. Arch Gen Psychiatry. 1994 Feb;51(2):85-97. DMR9Q4Y RU https://pubmed.ncbi.nlm.nih.gov/8297216 DMR9Q4Y DI DMR9Q4Y DMR9Q4Y DN 2-(1H-indol-3-yl)-N,N-dimethylethanamine DMR9Q4Y MI TT5TPI6 DMR9Q4Y MN Opioid receptor sigma 1 (OPRS1) DMR9Q4Y MT DTT DMR9Q4Y MA Inhibitor DMR9Q4Y RN Dose-response study of N,N-dimethyltryptamine in humans. I. Neuroendocrine, autonomic, and cardiovascular effects. Arch Gen Psychiatry. 1994 Feb;51(2):85-97. DMR9Q4Y RU https://pubmed.ncbi.nlm.nih.gov/8297216 DMB7AU5 DI DMB7AU5 DMB7AU5 DN 2-(1H-Indol-3-ylmethyl)-1,2-dihydro-indazol-3-one DMB7AU5 MI TT2J34L DMB7AU5 MN Arachidonate 5-lipoxygenase (5-LOX) DMB7AU5 MT DTT DMB7AU5 MA Inhibitor DMB7AU5 RN Indazolinones, a new series of redox-active 5-lipoxygenase inhibitors with built-in selectivity and oral activity. J Med Chem. 1991 Mar;34(3):1028-36. DMB7AU5 RU https://pubmed.ncbi.nlm.nih.gov/1848292 DMZNML4 DI DMZNML4 DMZNML4 DN 2-(1H-indol-5-yl)-6-morpholino-4H-pyran-4-one DMZNML4 MI TTK3PY9 DMZNML4 MN DNA-dependent protein kinase catalytic (PRKDC) DMZNML4 MT DTT DMZNML4 MA Inhibitor DMZNML4 RN Pyranone, thiopyranone, and pyridone inhibitors of phosphatidylinositol 3-kinase related kinases. Structure-activity relationships for DNA-dependen... J Med Chem. 2007 Apr 19;50(8):1958-72. DMZNML4 RU https://pubmed.ncbi.nlm.nih.gov/17371003 DMHSORL DI DMHSORL DMHSORL DN 2-(1H-pyrazol-3-yl)-1H-benzimidazole DMHSORL MI TTPS3C0 DMHSORL MN Aurora kinase A (AURKA) DMHSORL MT DTT DMHSORL MA Inhibitor DMHSORL RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DMHSORL RU https://pubmed.ncbi.nlm.nih.gov/10592235 DMUY75A DI DMUY75A DMUY75A DN 2-(1H-pyrrol-1-ylcarbonyl)benzene-1,3,5-triol DMUY75A MI TT78R5H DMUY75A MN Heat shock protein 90 alpha (HSP90A) DMUY75A MT DTT DMUY75A MA Inhibitor DMUY75A RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DMUY75A RU https://pubmed.ncbi.nlm.nih.gov/10592235 DM4MIXK DI DM4MIXK DM4MIXK DN 2-(1-Imidazol-1-yl-ethyl)-9H-carbazole DM4MIXK MI TTRA5BZ DM4MIXK MN Steroid 17-alpha-monooxygenase (S17AH) DM4MIXK MT DTT DM4MIXK MA Inhibitor DM4MIXK RN Synthesis, biological evaluation, and molecular modeling studies of methylene imidazole substituted biaryls as inhibitors of human 17alpha-hydroxyl... Bioorg Med Chem. 2008 Aug 15;16(16):7715-27. DM4MIXK RU https://pubmed.ncbi.nlm.nih.gov/18674917 DMY35HG DI DMY35HG DMY35HG DN 2-(1-o-tolyl-1H-pyrrol-3-yl)ethanamine DMY35HG MI TTO9X1H DMY35HG MN 5-HT 7 receptor (HTR7) DMY35HG MT DTT DMY35HG MA Inhibitor DMY35HG RN Novel aminoethylbiphenyls as 5-HT7 receptor ligands. Bioorg Med Chem Lett. 2007 Jun 1;17(11):3018-22. DMY35HG RU https://pubmed.ncbi.nlm.nih.gov/17419056 DMR0HDF DI DMR0HDF DMR0HDF DN 2-(1-Pentyl-hexyl)-4-phenyl-1H-imidazole DMR0HDF MI TTRK8B9 DMR0HDF MN Sodium channel unspecific (NaC) DMR0HDF MT DTT DMR0HDF MA Inhibitor DMR0HDF RN 2-Alkyl-4-arylimidazoles: structurally novel sodium channel modulators. Bioorg Med Chem Lett. 2004 Jul 5;14(13):3521-3. DMR0HDF RU https://pubmed.ncbi.nlm.nih.gov/15177465 DMR0HDF DI DMR0HDF DMR0HDF DN 2-(1-Pentyl-hexyl)-4-phenyl-1H-imidazole DMR0HDF MI TTAXZ0K DMR0HDF MN Voltage-gated sodium channel alpha Nav1.3 (SCN3A) DMR0HDF MT DTT DMR0HDF MA Inhibitor DMR0HDF RN 2-Alkyl-4-arylimidazoles: structurally novel sodium channel modulators. Bioorg Med Chem Lett. 2004 Jul 5;14(13):3521-3. DMR0HDF RU https://pubmed.ncbi.nlm.nih.gov/15177465 DMXCID6 DI DMXCID6 DMXCID6 DN 2-(1-tosyl-1H-indol-3-yl)ethanamine DMXCID6 MI TTJS8PY DMXCID6 MN 5-HT 6 receptor (HTR6) DMXCID6 MT DTT DMXCID6 MA Inhibitor DMXCID6 RN Discovery of N1-(6-chloroimidazo[2,1-b][1,3]thiazole-5-sulfonyl)tryptamine as a potent, selective, and orally active 5-HT(6) receptor agonist. J Med Chem. 2007 Nov 15;50(23):5535-8. DMXCID6 RU https://pubmed.ncbi.nlm.nih.gov/17948978 DMGZKCT DI DMGZKCT DMGZKCT DN 2-(2-((benzylamino)methyl)phenoxy)-5-chlorophenol DMGZKCT MI TTNX2CS DMGZKCT MN Plasmodium Enoyl-ACP reductase (Malaria fabI) DMGZKCT MT DTT DMGZKCT MA Inhibitor DMGZKCT RN Synthesis and biological activity of diaryl ether inhibitors of malarial enoyl acyl carrier protein reductase. Part 2: 2'-substituted triclosan der... Bioorg Med Chem Lett. 2006 Apr 15;16(8):2163-9. DMGZKCT RU https://pubmed.ncbi.nlm.nih.gov/16466916 DM54M6C DI DM54M6C DM54M6C DN 2-(2-(2,5-dichlorophenylamino)phenyl)acetic acid DM54M6C MI TTCTE1G DM54M6C MN Interleukin-8 (IL8) DM54M6C MT DTT DM54M6C MA Inhibitor DM54M6C RN Structure-Activity Relationship of novel phenylacetic CXCR1 inhibitors. Bioorg Med Chem Lett. 2009 Aug 1;19(15):4026-30. DM54M6C RU https://pubmed.ncbi.nlm.nih.gov/19560921 DMJ2DE4 DI DMJ2DE4 DMJ2DE4 DN 2-(2-(2,6-dimethylphenylamino)phenyl)acetic acid DMJ2DE4 MI TT8NGED DMJ2DE4 MN Prostaglandin G/H synthase 1 (COX-1) DMJ2DE4 MT DTT DMJ2DE4 MA Inhibitor DMJ2DE4 RN Molecular determinants for the selective inhibition of cyclooxygenase-2 by lumiracoxib. J Biol Chem. 2007 Jun 1;282(22):16379-90. DMJ2DE4 RU https://pubmed.ncbi.nlm.nih.gov/17434872 DMJ2DE4 DI DMJ2DE4 DMJ2DE4 DN 2-(2-(2,6-dimethylphenylamino)phenyl)acetic acid DMJ2DE4 MI TTVKILB DMJ2DE4 MN Prostaglandin G/H synthase 2 (COX-2) DMJ2DE4 MT DTT DMJ2DE4 MA Inhibitor DMJ2DE4 RN Molecular determinants for the selective inhibition of cyclooxygenase-2 by lumiracoxib. J Biol Chem. 2007 Jun 1;282(22):16379-90. DMJ2DE4 RU https://pubmed.ncbi.nlm.nih.gov/17434872 DMBP1TQ DI DMBP1TQ DMBP1TQ DN 2-(2-(2-chlorophenoxy)phenyl)acetic acid DMBP1TQ MI TTCTE1G DMBP1TQ MN Interleukin-8 (IL8) DMBP1TQ MT DTT DMBP1TQ MA Inhibitor DMBP1TQ RN Structure-Activity Relationship of novel phenylacetic CXCR1 inhibitors. Bioorg Med Chem Lett. 2009 Aug 1;19(15):4026-30. DMBP1TQ RU https://pubmed.ncbi.nlm.nih.gov/19560921 DMPLV3A DI DMPLV3A DMPLV3A DN 2-(2-(2-chlorophenylamino)phenyl)acetic acid DMPLV3A MI TTCTE1G DMPLV3A MN Interleukin-8 (IL8) DMPLV3A MT DTT DMPLV3A MA Inhibitor DMPLV3A RN Structure-Activity Relationship of novel phenylacetic CXCR1 inhibitors. Bioorg Med Chem Lett. 2009 Aug 1;19(15):4026-30. DMPLV3A RU https://pubmed.ncbi.nlm.nih.gov/19560921 DMDSUR2 DI DMDSUR2 DMDSUR2 DN 2-(2-(2-fluorophenoxy)phenyl)acetic acid DMDSUR2 MI TTCTE1G DMDSUR2 MN Interleukin-8 (IL8) DMDSUR2 MT DTT DMDSUR2 MA Inhibitor DMDSUR2 RN Structure-Activity Relationship of novel phenylacetic CXCR1 inhibitors. Bioorg Med Chem Lett. 2009 Aug 1;19(15):4026-30. DMDSUR2 RU https://pubmed.ncbi.nlm.nih.gov/19560921 DMVQ68F DI DMVQ68F DMVQ68F DN 2-(2-(2-fluorophenylamino)phenyl)acetic acid DMVQ68F MI TTCTE1G DMVQ68F MN Interleukin-8 (IL8) DMVQ68F MT DTT DMVQ68F MA Inhibitor DMVQ68F RN Structure-Activity Relationship of novel phenylacetic CXCR1 inhibitors. Bioorg Med Chem Lett. 2009 Aug 1;19(15):4026-30. DMVQ68F RU https://pubmed.ncbi.nlm.nih.gov/19560921 DMKT51Z DI DMKT51Z DMKT51Z DN 2-(2-(4-tert-butylphenoxy)acetamido)benzoic acid DMKT51Z MI TTWNV8U DMKT51Z MN Nicotinic acid receptor (HCAR2) DMKT51Z MT DTT DMKT51Z MA Inhibitor DMKT51Z RN Molecular modeling aided design of nicotinic acid receptor GPR109A agonists. Bioorg Med Chem Lett. 2008 Sep 15;18(18):4963-7. DMKT51Z RU https://pubmed.ncbi.nlm.nih.gov/18760600 DMZVBPG DI DMZVBPG DMZVBPG DN 2-(2-(4-tert-Butylphenylthio)ethyl)-1H-imidazole DMZVBPG MI TTXV4FI DMZVBPG MN Albendazole monooxygenase (CYP3A4) DMZVBPG MT DTT DMZVBPG MA Inhibitor DMZVBPG RN Role of hydrophobic substituents on the terminal nitrogen of histamine in receptor binding and agonist activity: development of an orally active hi... J Med Chem. 2010 May 13;53(9):3840-4. DMZVBPG RU https://pubmed.ncbi.nlm.nih.gov/20384344 DMZVBPG DI DMZVBPG DMZVBPG DN 2-(2-(4-tert-Butylphenylthio)ethyl)-1H-imidazole DMZVBPG MI TTVG215 DMZVBPG MN Debrisoquine 4-hydroxylase (CYP2D6) DMZVBPG MT DTT DMZVBPG MA Inhibitor DMZVBPG RN Role of hydrophobic substituents on the terminal nitrogen of histamine in receptor binding and agonist activity: development of an orally active hi... J Med Chem. 2010 May 13;53(9):3840-4. DMZVBPG RU https://pubmed.ncbi.nlm.nih.gov/20384344 DMZVBPG DI DMZVBPG DMZVBPG DN 2-(2-(4-tert-Butylphenylthio)ethyl)-1H-imidazole DMZVBPG MI TT9JNIC DMZVBPG MN Histamine H3 receptor (H3R) DMZVBPG MT DTT DMZVBPG MA Inhibitor DMZVBPG RN Investigation of the histamine H3 receptor binding site. Design and synthesis of hybrid agonists with a lipophilic side chain. J Med Chem. 2010 Sep 9;53(17):6445-56. DMZVBPG RU https://pubmed.ncbi.nlm.nih.gov/20690643 DMZVBPG DI DMZVBPG DMZVBPG DN 2-(2-(4-tert-Butylphenylthio)ethyl)-1H-imidazole DMZVBPG MI TTXJ178 DMZVBPG MN Histamine H4 receptor (H4R) DMZVBPG MT DTT DMZVBPG MA Inhibitor DMZVBPG RN Synthesis and structure-activity relationships of N-aryl-piperidine derivatives as potent (partial) agonists for human histamine H3 receptor. Bioorg Med Chem. 2010 Jul 15;18(14):5441-8. DMZVBPG RU https://pubmed.ncbi.nlm.nih.gov/20541426 DMDR50V DI DMDR50V DMDR50V DN 2-(2-(biphenyl-4-yl)ethylsulfinyl)acetic acid DMDR50V MI TTXZ0KQ DMDR50V MN Matrix metalloproteinase-12 (MMP-12) DMDR50V MT DTT DMDR50V MA Inhibitor DMDR50V RN The identification of beta-hydroxy carboxylic acids as selective MMP-12 inhibitors. Bioorg Med Chem Lett. 2009 Oct 1;19(19):5760-3. DMDR50V RU https://pubmed.ncbi.nlm.nih.gov/19703773 DM95B4J DI DM95B4J DM95B4J DN 2-(2-(biphenyl-4-yl)ethylsulfonyl)acetic acid DM95B4J MI TTXZ0KQ DM95B4J MN Matrix metalloproteinase-12 (MMP-12) DM95B4J MT DTT DM95B4J MA Inhibitor DM95B4J RN The identification of beta-hydroxy carboxylic acids as selective MMP-12 inhibitors. Bioorg Med Chem Lett. 2009 Oct 1;19(19):5760-3. DM95B4J RU https://pubmed.ncbi.nlm.nih.gov/19703773 DM95B4J DI DM95B4J DM95B4J DN 2-(2-(biphenyl-4-yl)ethylsulfonyl)acetic acid DM95B4J MI TTHY57M DM95B4J MN Matrix metalloproteinase-13 (MMP-13) DM95B4J MT DTT DM95B4J MA Inhibitor DM95B4J RN The identification of beta-hydroxy carboxylic acids as selective MMP-12 inhibitors. Bioorg Med Chem Lett. 2009 Oct 1;19(19):5760-3. DM95B4J RU https://pubmed.ncbi.nlm.nih.gov/19703773 DMBZIUC DI DMBZIUC DMBZIUC DN 2-(2-(biphenyl-4-yl)ethylthio)acetic acid DMBZIUC MI TTXZ0KQ DMBZIUC MN Matrix metalloproteinase-12 (MMP-12) DMBZIUC MT DTT DMBZIUC MA Inhibitor DMBZIUC RN The identification of beta-hydroxy carboxylic acids as selective MMP-12 inhibitors. Bioorg Med Chem Lett. 2009 Oct 1;19(19):5760-3. DMBZIUC RU https://pubmed.ncbi.nlm.nih.gov/19703773 DMZA8M7 DI DMZA8M7 DMZA8M7 DN 2-(2-(butylamino)pyrimidin-4-ylamino)benzoic acid DMZA8M7 MI TT0K6EO DMZA8M7 MN Stress-activated protein kinase JNK1 (JNK1) DMZA8M7 MT DTT DMZA8M7 MA Inhibitor DMZA8M7 RN Discovery of a new class of 4-anilinopyrimidines as potent c-Jun N-terminal kinase inhibitors: Synthesis and SAR studies. Bioorg Med Chem Lett. 2007 Feb 1;17(3):668-72. DMZA8M7 RU https://pubmed.ncbi.nlm.nih.gov/17107797 DM4KS27 DI DM4KS27 DM4KS27 DN 2-(2-(pentyloxy)pyrimidin-4-ylamino)benzoic acid DM4KS27 MI TT0K6EO DM4KS27 MN Stress-activated protein kinase JNK1 (JNK1) DM4KS27 MT DTT DM4KS27 MA Inhibitor DM4KS27 RN Discovery of a new class of 4-anilinopyrimidines as potent c-Jun N-terminal kinase inhibitors: Synthesis and SAR studies. Bioorg Med Chem Lett. 2007 Feb 1;17(3):668-72. DM4KS27 RU https://pubmed.ncbi.nlm.nih.gov/17107797 DM5GAOZ DI DM5GAOZ DM5GAOZ DN 2-(2-(phenylamino)pyrimidin-4-ylamino)benzamide DM5GAOZ MI TT0K6EO DM5GAOZ MN Stress-activated protein kinase JNK1 (JNK1) DM5GAOZ MT DTT DM5GAOZ MA Inhibitor DM5GAOZ RN Discovery of a new class of 4-anilinopyrimidines as potent c-Jun N-terminal kinase inhibitors: Synthesis and SAR studies. Bioorg Med Chem Lett. 2007 Feb 1;17(3):668-72. DM5GAOZ RU https://pubmed.ncbi.nlm.nih.gov/17107797 DMCHZ8J DI DMCHZ8J DMCHZ8J DN 2-(2-(pyrrolidin-1-yl)ethyl)-1H-indole DMCHZ8J MI TT9JNIC DMCHZ8J MN Histamine H3 receptor (H3R) DMCHZ8J MT DTT DMCHZ8J MA Inhibitor DMCHZ8J RN In vitro SAR of pyrrolidine-containing histamine H3 receptor antagonists: trends across multiple chemical series. Bioorg Med Chem Lett. 2008 Jan 1;18(1):355-9. DMCHZ8J RU https://pubmed.ncbi.nlm.nih.gov/18077160 DMQ0WKA DI DMQ0WKA DMQ0WKA DN 2-(2-(pyrrolidin-1-yl)ethyl)phenol DMQ0WKA MI TT9JNIC DMQ0WKA MN Histamine H3 receptor (H3R) DMQ0WKA MT DTT DMQ0WKA MA Inhibitor DMQ0WKA RN In vitro SAR of pyrrolidine-containing histamine H3 receptor antagonists: trends across multiple chemical series. Bioorg Med Chem Lett. 2008 Jan 1;18(1):355-9. DMQ0WKA RU https://pubmed.ncbi.nlm.nih.gov/18077160 DMGQC2F DI DMGQC2F DMGQC2F DN 2-(2-(pyrrolidin-1-yl)ethyl)pyridine DMGQC2F MI TT9JNIC DMGQC2F MN Histamine H3 receptor (H3R) DMGQC2F MT DTT DMGQC2F MA Inhibitor DMGQC2F RN In vitro SAR of pyrrolidine-containing histamine H3 receptor antagonists: trends across multiple chemical series. Bioorg Med Chem Lett. 2008 Jan 1;18(1):355-9. DMGQC2F RU https://pubmed.ncbi.nlm.nih.gov/18077160 DMFU1PK DI DMFU1PK DMFU1PK DN 2-(2,3,4-trimethoxyphenyl)-1H-indene DMFU1PK MI TT8NGED DMFU1PK MN Prostaglandin G/H synthase 1 (COX-1) DMFU1PK MT DTT DMFU1PK MA Inhibitor DMFU1PK RN 'Bridged' stilbene derivatives as selective cyclooxygenase-1 inhibitors. Bioorg Med Chem. 2007 Sep 15;15(18):6109-18. DMFU1PK RU https://pubmed.ncbi.nlm.nih.gov/17604631 DMFU1PK DI DMFU1PK DMFU1PK DN 2-(2,3,4-trimethoxyphenyl)-1H-indene DMFU1PK MI TTVKILB DMFU1PK MN Prostaglandin G/H synthase 2 (COX-2) DMFU1PK MT DTT DMFU1PK MA Inhibitor DMFU1PK RN 'Bridged' stilbene derivatives as selective cyclooxygenase-1 inhibitors. Bioorg Med Chem. 2007 Sep 15;15(18):6109-18. DMFU1PK RU https://pubmed.ncbi.nlm.nih.gov/17604631 DM1T8IP DI DM1T8IP DM1T8IP DN 2-(2,3-bis(2-chlorobenzyloxy)phenyl)acetic acid DM1T8IP MI TTHWMFZ DM1T8IP MN Fatty acid-binding protein 4 (FABP4) DM1T8IP MT DTT DM1T8IP MA Inhibitor DM1T8IP RN NMR structure of a potent small molecule inhibitor bound to human keratinocyte fatty acid-binding protein. J Med Chem. 2006 Aug 10;49(16):5013-7. DM1T8IP RU https://pubmed.ncbi.nlm.nih.gov/16884313 DM1T8IP DI DM1T8IP DM1T8IP DN 2-(2,3-bis(2-chlorobenzyloxy)phenyl)acetic acid DM1T8IP MI TTNT2S6 DM1T8IP MN Fatty acid-binding protein 5 (FABP5) DM1T8IP MT DTT DM1T8IP MA Inhibitor DM1T8IP RN NMR structure of a potent small molecule inhibitor bound to human keratinocyte fatty acid-binding protein. J Med Chem. 2006 Aug 10;49(16):5013-7. DM1T8IP RU https://pubmed.ncbi.nlm.nih.gov/16884313 DM56NK4 DI DM56NK4 DM56NK4 DN 2-(2,3-Dihydro-1H-indol-5-yl)-1-methyl-ethylamine DM56NK4 MI TTVBI8W DM56NK4 MN Dopamine transporter (DAT) DM56NK4 MT DTT DM56NK4 MA Inhibitor DM56NK4 RN Selective monoamine oxidase inhibitors. 3. Cyclic compounds related to 4-aminophenethylamine. Preparation and neuron-selective action of some 5-(2-... J Med Chem. 1986 Aug;29(8):1406-12. DM56NK4 RU https://pubmed.ncbi.nlm.nih.gov/3735309 DM56NK4 DI DM56NK4 DM56NK4 DN 2-(2,3-Dihydro-1H-indol-5-yl)-1-methyl-ethylamine DM56NK4 MI TTAWNKZ DM56NK4 MN Norepinephrine transporter (NET) DM56NK4 MT DTT DM56NK4 MA Inhibitor DM56NK4 RN Selective monoamine oxidase inhibitors. 3. Cyclic compounds related to 4-aminophenethylamine. Preparation and neuron-selective action of some 5-(2-... J Med Chem. 1986 Aug;29(8):1406-12. DM56NK4 RU https://pubmed.ncbi.nlm.nih.gov/3735309 DM4XL8Z DI DM4XL8Z DM4XL8Z DN 2-(2,4-dichlorophenoxy)-5-(2-methylbutyl)phenol DM4XL8Z MI TTNX2CS DM4XL8Z MN Plasmodium Enoyl-ACP reductase (Malaria fabI) DM4XL8Z MT DTT DM4XL8Z MA Inhibitor DM4XL8Z RN Design and in silico screening of combinatorial library of antimalarial analogs of triclosan inhibiting Plasmodium falciparum enoyl-acyl carrier pr... Eur J Med Chem. 2009 Jul;44(7):3009-19. DM4XL8Z RU https://pubmed.ncbi.nlm.nih.gov/19217192 DME3FUD DI DME3FUD DME3FUD DN 2-(2,4-dichlorophenoxy)-5-(3-phenylpropyl)phenol DME3FUD MI TTNX2CS DME3FUD MN Plasmodium Enoyl-ACP reductase (Malaria fabI) DME3FUD MT DTT DME3FUD MA Inhibitor DME3FUD RN X-ray structural analysis of Plasmodium falciparum enoyl acyl carrier protein reductase as a pathway toward the optimization of triclosan antimalar... J Biol Chem. 2007 Aug 31;282(35):25436-44. DME3FUD RU https://pubmed.ncbi.nlm.nih.gov/17567585 DMPSR1O DI DMPSR1O DMPSR1O DN 2-(2,4-dichlorophenoxy)-5-ethylphenol DMPSR1O MI TTNX2CS DMPSR1O MN Plasmodium Enoyl-ACP reductase (Malaria fabI) DMPSR1O MT DTT DMPSR1O MA Inhibitor DMPSR1O RN X-ray structural analysis of Plasmodium falciparum enoyl acyl carrier protein reductase as a pathway toward the optimization of triclosan antimalar... J Biol Chem. 2007 Aug 31;282(35):25436-44. DMPSR1O RU https://pubmed.ncbi.nlm.nih.gov/17567585 DMKOFRE DI DMKOFRE DMKOFRE DN 2-(2,4-dichlorophenoxy)-5-isobutylphenol DMKOFRE MI TTNX2CS DMKOFRE MN Plasmodium Enoyl-ACP reductase (Malaria fabI) DMKOFRE MT DTT DMKOFRE MA Inhibitor DMKOFRE RN Design and in silico screening of combinatorial library of antimalarial analogs of triclosan inhibiting Plasmodium falciparum enoyl-acyl carrier pr... Eur J Med Chem. 2009 Jul;44(7):3009-19. DMKOFRE RU https://pubmed.ncbi.nlm.nih.gov/19217192 DME0LZ2 DI DME0LZ2 DME0LZ2 DN 2-(2,4-dichlorophenoxy)-5-isopentylphenol DME0LZ2 MI TTNX2CS DME0LZ2 MN Plasmodium Enoyl-ACP reductase (Malaria fabI) DME0LZ2 MT DTT DME0LZ2 MA Inhibitor DME0LZ2 RN Design and in silico screening of combinatorial library of antimalarial analogs of triclosan inhibiting Plasmodium falciparum enoyl-acyl carrier pr... Eur J Med Chem. 2009 Jul;44(7):3009-19. DME0LZ2 RU https://pubmed.ncbi.nlm.nih.gov/19217192 DM1L3US DI DM1L3US DM1L3US DN 2-(2,4-dichlorophenoxy)-5-methylphenol DM1L3US MI TTNX2CS DM1L3US MN Plasmodium Enoyl-ACP reductase (Malaria fabI) DM1L3US MT DTT DM1L3US MA Inhibitor DM1L3US RN X-ray structural analysis of Plasmodium falciparum enoyl acyl carrier protein reductase as a pathway toward the optimization of triclosan antimalar... J Biol Chem. 2007 Aug 31;282(35):25436-44. DM1L3US RU https://pubmed.ncbi.nlm.nih.gov/17567585 DM6ZNR3 DI DM6ZNR3 DM6ZNR3 DN 2-(2,4-dichlorophenoxy)-5-phenethylphenol DM6ZNR3 MI TTNX2CS DM6ZNR3 MN Plasmodium Enoyl-ACP reductase (Malaria fabI) DM6ZNR3 MT DTT DM6ZNR3 MA Inhibitor DM6ZNR3 RN Design and in silico screening of combinatorial library of antimalarial analogs of triclosan inhibiting Plasmodium falciparum enoyl-acyl carrier pr... Eur J Med Chem. 2009 Jul;44(7):3009-19. DM6ZNR3 RU https://pubmed.ncbi.nlm.nih.gov/19217192 DMKP974 DI DMKP974 DMKP974 DN 2-(2,4-dichlorophenoxy)-5-propylphenol DMKP974 MI TTNX2CS DMKP974 MN Plasmodium Enoyl-ACP reductase (Malaria fabI) DMKP974 MT DTT DMKP974 MA Inhibitor DMKP974 RN X-ray structural analysis of Plasmodium falciparum enoyl acyl carrier protein reductase as a pathway toward the optimization of triclosan antimalar... J Biol Chem. 2007 Aug 31;282(35):25436-44. DMKP974 RU https://pubmed.ncbi.nlm.nih.gov/17567585 DMDUF21 DI DMDUF21 DMDUF21 DN 2-(2,4-dichlorophenyl)-4,5-dihydro-1H-imidazole DMDUF21 MI TTGP7BY DMDUF21 MN Monoamine oxidase type B (MAO-B) DMDUF21 MT DTT DMDUF21 MA Inhibitor DMDUF21 RN Ultrasound promoted synthesis of 2-imidazolines in water: a greener approach toward monoamine oxidase inhibitors. Bioorg Med Chem Lett. 2009 Jan 15;19(2):546-9. DMDUF21 RU https://pubmed.ncbi.nlm.nih.gov/19064321 DMSND8U DI DMSND8U DMSND8U DN 2-(2,4-difluorophenyl)-2,2-diphenylacetamide DMSND8U MI TTMNI76 DMSND8U MN Calcium-activated potassium channel (KCN) DMSND8U MT DTT DMSND8U MA Inhibitor DMSND8U RN Novel inhibitors of the Gardos channel for the treatment of sickle cell disease. J Med Chem. 2008 Feb 28;51(4):976-82. DMSND8U RU https://pubmed.ncbi.nlm.nih.gov/18232633 DMG49N2 DI DMG49N2 DMG49N2 DN 2-(2,4-diphenylthiazol-5-yl)acetic acid DMG49N2 MI TTQDMX5 DMG49N2 MN Prostaglandin D2 receptor 2 (PTGDR2) DMG49N2 MT DTT DMG49N2 MA Inhibitor DMG49N2 RN Novel selective thiazoleacetic acids as CRTH2 antagonists developed from in silico derived hits. Part 1. Bioorg Med Chem Lett. 2010 Feb 1;20(3):1177-80. DMG49N2 RU https://pubmed.ncbi.nlm.nih.gov/20031403 DM7JUK0 DI DM7JUK0 DM7JUK0 DN 2-(2,6-Dimethyl-benzyl)-4,5-dihydro-1H-imidazole DM7JUK0 MI TT6MSOK DM7JUK0 MN 5-HT 1D receptor (HTR1D) DM7JUK0 MT DTT DM7JUK0 MA Inhibitor DM7JUK0 RN 2-(Anilino)imidazolines and 2-(benzyl)imidazoline derivatives as h5-HT1D serotonin receptor ligands. Bioorg Med Chem Lett. 2004 Sep 20;14(18):4697-9. DM7JUK0 RU https://pubmed.ncbi.nlm.nih.gov/15324890 DMITKZY DI DMITKZY DMITKZY DN 2-(2-acetyl-4-bromophenoxy)acetic acid DMITKZY MI TTQDMX5 DMITKZY MN Prostaglandin D2 receptor 2 (PTGDR2) DMITKZY MT DTT DMITKZY MA Inhibitor DMITKZY RN Novel selective orally active CRTH2 antagonists for allergic inflammation developed from in silico derived hits. J Med Chem. 2006 Nov 16;49(23):6638-41. DMITKZY RU https://pubmed.ncbi.nlm.nih.gov/17154491 DMP1KZW DI DMP1KZW DMP1KZW DN 2-(2-adamantyl) piperidine DMP1KZW MI TTXT3PU DMP1KZW MN Influenza M2 protein (Influ M) DMP1KZW MT DTT DMP1KZW MA Inhibitor DMP1KZW RN Antiviral agents active against influenza A viruses. Nat Rev Drug Discov. 2006 Dec;5(12):1015-25. DMP1KZW RU https://pubmed.ncbi.nlm.nih.gov/17139286 DMXDGEF DI DMXDGEF DMXDGEF DN 2-(2-allyl-4-chlorophenoxy)acetic acid DMXDGEF MI TTQDMX5 DMXDGEF MN Prostaglandin D2 receptor 2 (PTGDR2) DMXDGEF MT DTT DMXDGEF MA Inhibitor DMXDGEF RN 2-Cycloalkyl phenoxyacetic acid CRTh2 receptor antagonists. Bioorg Med Chem Lett. 2007 Aug 1;17(15):4347-50. DMXDGEF RU https://pubmed.ncbi.nlm.nih.gov/17531480 DMVTD1F DI DMVTD1F DMVTD1F DN 2-(2'-Aminoethyl)-5-benzyltetrahydrofuran DMVTD1F MI TTVBI8W DMVTD1F MN Dopamine transporter (DAT) DMVTD1F MT DTT DMVTD1F MA Inhibitor DMVTD1F RN 2,5-Disubstituted tetrahydrofurans as selective serotonin re-uptake inhibitors. Bioorg Med Chem. 2009 Mar 1;17(5):2047-68. DMVTD1F RU https://pubmed.ncbi.nlm.nih.gov/19201198 DMVTD1F DI DMVTD1F DMVTD1F DN 2-(2'-Aminoethyl)-5-benzyltetrahydrofuran DMVTD1F MI TTAWNKZ DMVTD1F MN Norepinephrine transporter (NET) DMVTD1F MT DTT DMVTD1F MA Inhibitor DMVTD1F RN 2,5-Disubstituted tetrahydrofurans as selective serotonin re-uptake inhibitors. Bioorg Med Chem. 2009 Mar 1;17(5):2047-68. DMVTD1F RU https://pubmed.ncbi.nlm.nih.gov/19201198 DMVTD1F DI DMVTD1F DMVTD1F DN 2-(2'-Aminoethyl)-5-benzyltetrahydrofuran DMVTD1F MI TT3ROYC DMVTD1F MN Serotonin transporter (SERT) DMVTD1F MT DTT DMVTD1F MA Inhibitor DMVTD1F RN 2,5-Disubstituted tetrahydrofurans as selective serotonin re-uptake inhibitors. Bioorg Med Chem. 2009 Mar 1;17(5):2047-68. DMVTD1F RU https://pubmed.ncbi.nlm.nih.gov/19201198 DM3JM7V DI DM3JM7V DM3JM7V DN 2-(2-Amino-ethyl)-7-imino-azepane DM3JM7V MI TTZUFI5 DM3JM7V MN Nitric-oxide synthase brain (NOS1) DM3JM7V MT DTT DM3JM7V MA Inhibitor DM3JM7V RN Selective heterocyclic amidine inhibitors of human inducible nitric oxide synthase. Bioorg Med Chem Lett. 2001 Oct 8;11(19):2651-3. DM3JM7V RU https://pubmed.ncbi.nlm.nih.gov/11551770 DM3JM7V DI DM3JM7V DM3JM7V DN 2-(2-Amino-ethyl)-7-imino-azepane DM3JM7V MI TTF10I9 DM3JM7V MN Nitric-oxide synthase inducible (NOS2) DM3JM7V MT DTT DM3JM7V MA Inhibitor DM3JM7V RN Selective heterocyclic amidine inhibitors of human inducible nitric oxide synthase. Bioorg Med Chem Lett. 2001 Oct 8;11(19):2651-3. DM3JM7V RU https://pubmed.ncbi.nlm.nih.gov/11551770 DMDFYJR DI DMDFYJR DMDFYJR DN 2-(2-Aminoethyl)anthra[1,9-cd]pyrazol-6(2H)-one DMDFYJR MI TT0IHXV DMDFYJR MN DNA topoisomerase II (TOP2) DMDFYJR MT DTT DMDFYJR MA Inhibitor DMDFYJR RN Design, synthesis and biological evaluation of a novel series of anthrapyrazoles linked with netropsin-like oligopyrrole carboxamides as anticancer... Bioorg Med Chem. 2010 Jun 1;18(11):3974-84. DMDFYJR RU https://pubmed.ncbi.nlm.nih.gov/20471276 DMM9A8G DI DMM9A8G DMM9A8G DN 2-(2-aminophenoxy)-5-hexylphenol DMM9A8G MI TTVTX4N DMM9A8G MN Bacterial Fatty acid synthetase I (Bact inhA) DMM9A8G MT DTT DMM9A8G MA Inhibitor DMM9A8G RN Synthesis and in vitro antimycobacterial activity of B-ring modified diaryl ether InhA inhibitors. Bioorg Med Chem Lett. 2008 May 15;18(10):3029-33. DMM9A8G RU https://pubmed.ncbi.nlm.nih.gov/18457948 DM0CWHT DI DM0CWHT DM0CWHT DN 2-(2-Amino-phenyl)-6-methyl-chromen-4-one DM0CWHT MI TTNJYV2 DM0CWHT MN Gamma-aminobutyric acid receptor (GAR) DM0CWHT MT DTT DM0CWHT MA Inhibitor DM0CWHT RN Refinement and evaluation of a pharmacophore model for flavone derivatives binding to the benzodiazepine site of the GABA(A) receptor. J Med Chem. 2002 Sep 12;45(19):4188-201. DM0CWHT RU https://pubmed.ncbi.nlm.nih.gov/12213060 DMCLSJZ DI DMCLSJZ DMCLSJZ DN 2-(2-aminophenyl)-6-morpholino-4H-pyran-4-one DMCLSJZ MI TTK3PY9 DMCLSJZ MN DNA-dependent protein kinase catalytic (PRKDC) DMCLSJZ MT DTT DMCLSJZ MA Inhibitor DMCLSJZ RN Pyranone, thiopyranone, and pyridone inhibitors of phosphatidylinositol 3-kinase related kinases. Structure-activity relationships for DNA-dependen... J Med Chem. 2007 Apr 19;50(8):1958-72. DMCLSJZ RU https://pubmed.ncbi.nlm.nih.gov/17371003 DMZNRFG DI DMZNRFG DMZNRFG DN 2-(2-Amino-propyl)-5-bromo-4-methoxy-phenol DMZNRFG MI TTSQIFT DMZNRFG MN 5-HT 1A receptor (HTR1A) DMZNRFG MT DTT DMZNRFG MA Inhibitor DMZNRFG RN 5-HT1 and 5-HT2 binding characteristics of 1-(2,5-dimethoxy-4-bromophenyl)-2-aminopropane analogues. J Med Chem. 1986 Feb;29(2):194-9. DMZNRFG RU https://pubmed.ncbi.nlm.nih.gov/3950904 DMZNRFG DI DMZNRFG DMZNRFG DN 2-(2-Amino-propyl)-5-bromo-4-methoxy-phenol DMZNRFG MI TT6MSOK DMZNRFG MN 5-HT 1D receptor (HTR1D) DMZNRFG MT DTT DMZNRFG MA Inhibitor DMZNRFG RN 5-HT1 and 5-HT2 binding characteristics of 1-(2,5-dimethoxy-4-bromophenyl)-2-aminopropane analogues. J Med Chem. 1986 Feb;29(2):194-9. DMZNRFG RU https://pubmed.ncbi.nlm.nih.gov/3950904 DMZNRFG DI DMZNRFG DMZNRFG DN 2-(2-Amino-propyl)-5-bromo-4-methoxy-phenol DMZNRFG MI TTJQOD7 DMZNRFG MN 5-HT 2A receptor (HTR2A) DMZNRFG MT DTT DMZNRFG MA Inhibitor DMZNRFG RN 5-HT1 and 5-HT2 binding characteristics of 1-(2,5-dimethoxy-4-bromophenyl)-2-aminopropane analogues. J Med Chem. 1986 Feb;29(2):194-9. DMZNRFG RU https://pubmed.ncbi.nlm.nih.gov/3950904 DMN6IV2 DI DMN6IV2 DMN6IV2 DN 2-(2-benzhydryl-4-phenylthiazol-5-yl)acetic acid DMN6IV2 MI TTQDMX5 DMN6IV2 MN Prostaglandin D2 receptor 2 (PTGDR2) DMN6IV2 MT DTT DMN6IV2 MA Inhibitor DMN6IV2 RN Novel selective thiazoleacetic acids as CRTH2 antagonists developed from in silico derived hits. Part 2. Bioorg Med Chem Lett. 2010 Feb 1;20(3):1181-5. DMN6IV2 RU https://pubmed.ncbi.nlm.nih.gov/20022749 DMLOD2Y DI DMLOD2Y DMLOD2Y DN 2-(2-benzoyl-4-bromophenoxy)acetic acid DMLOD2Y MI TTQDMX5 DMLOD2Y MN Prostaglandin D2 receptor 2 (PTGDR2) DMLOD2Y MT DTT DMLOD2Y MA Inhibitor DMLOD2Y RN Novel selective orally active CRTH2 antagonists for allergic inflammation developed from in silico derived hits. J Med Chem. 2006 Nov 16;49(23):6638-41. DMLOD2Y RU https://pubmed.ncbi.nlm.nih.gov/17154491 DMFK0GM DI DMFK0GM DMFK0GM DN 2-(2-bromo-2-naphthamido)benzoic acid DMFK0GM MI TT3PQ2Y DMFK0GM MN Plasmodium Dihydroorotate dehydrogenase (Malaria DHOdehase) DMFK0GM MT DTT DMFK0GM MA Inhibitor DMFK0GM RN The first de novo designed inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase. Bioorg Med Chem Lett. 2006 Jan 1;16(1):88-92. DMFK0GM RU https://pubmed.ncbi.nlm.nih.gov/16236496 DM3VH7F DI DM3VH7F DM3VH7F DN 2-(2-Bromo-benzoyl)-cyclohexane-1,3-dione DM3VH7F MI TT8DSFC DM3VH7F MN Hydroxyphenylpyruvate dioxygenase (HPD) DM3VH7F MT DTT DM3VH7F MA Inhibitor DM3VH7F RN SAR studies of 2-o-substituted-benzoyl- and 2-alkanoyl-cyclohexane-1,3-diones as inhibitors of 4-hydroxyphenylpyruvate dioxygenase. Bioorg Med Chem Lett. 2000 May 1;10(9):843-5. DM3VH7F RU https://pubmed.ncbi.nlm.nih.gov/10853644 DMHBE0X DI DMHBE0X DMHBE0X DN 2-(2-Bromophenoxy)-N,N-dimethylethanamine DMHBE0X MI TTO9X1H DMHBE0X MN 5-HT 7 receptor (HTR7) DMHBE0X MT DTT DMHBE0X MA Inhibitor DMHBE0X RN SAR studies on new bis-aryls 5-HT7 ligands: Synthesis and molecular modeling. Bioorg Med Chem. 2010 Mar 1;18(5):1958-67. DMHBE0X RU https://pubmed.ncbi.nlm.nih.gov/20138771 DMHJMUX DI DMHJMUX DMHJMUX DN 2-(2-Bromophenylthio)-N,N-dimethylethanamine DMHJMUX MI TTO9X1H DMHJMUX MN 5-HT 7 receptor (HTR7) DMHJMUX MT DTT DMHJMUX MA Inhibitor DMHJMUX RN SAR studies on new bis-aryls 5-HT7 ligands: Synthesis and molecular modeling. Bioorg Med Chem. 2010 Mar 1;18(5):1958-67. DMHJMUX RU https://pubmed.ncbi.nlm.nih.gov/20138771 DMLTU3J DI DMLTU3J DMLTU3J DN 2-(2-butoxypyrimidin-4-ylamino)benzoic acid DMLTU3J MI TT0K6EO DMLTU3J MN Stress-activated protein kinase JNK1 (JNK1) DMLTU3J MT DTT DMLTU3J MA Inhibitor DMLTU3J RN Discovery of a new class of 4-anilinopyrimidines as potent c-Jun N-terminal kinase inhibitors: Synthesis and SAR studies. Bioorg Med Chem Lett. 2007 Feb 1;17(3):668-72. DMLTU3J RU https://pubmed.ncbi.nlm.nih.gov/17107797 DMEGY0T DI DMEGY0T DMEGY0T DN 2-(2-carboxy-5-mercaptopentyl)benzoic acid DMEGY0T MI TT9G4N0 DMEGY0T MN Glutamate carboxypeptidase II (GCPII) DMEGY0T MT DTT DMEGY0T MA Inhibitor DMEGY0T RN Structural optimization of thiol-based inhibitors of glutamate carboxypeptidase II by modification of the P1' side chain. J Med Chem. 2006 May 18;49(10):2876-85. DMEGY0T RU https://pubmed.ncbi.nlm.nih.gov/16686531 DMR98ML DI DMR98ML DMR98ML DN 2-(2-carboxy-7-mercaptoheptyl)benzoic acid DMR98ML MI TT9G4N0 DMR98ML MN Glutamate carboxypeptidase II (GCPII) DMR98ML MT DTT DMR98ML MA Inhibitor DMR98ML RN Structural optimization of thiol-based inhibitors of glutamate carboxypeptidase II by modification of the P1' side chain. J Med Chem. 2006 May 18;49(10):2876-85. DMR98ML RU https://pubmed.ncbi.nlm.nih.gov/16686531 DMWDV71 DI DMWDV71 DMWDV71 DN 2-(2-Chloro-4-hydroxy-phenyl)-benzooxazol-5-ol DMWDV71 MI TTZAYWL DMWDV71 MN Estrogen receptor (ESR) DMWDV71 MT DTT DMWDV71 MA Inhibitor DMWDV71 RN Design and synthesis of aryl diphenolic azoles as potent and selective estrogen receptor-beta ligands. J Med Chem. 2004 Oct 7;47(21):5021-40. DMWDV71 RU https://pubmed.ncbi.nlm.nih.gov/15456246 DMWDV71 DI DMWDV71 DMWDV71 DN 2-(2-Chloro-4-hydroxy-phenyl)-benzooxazol-5-ol DMWDV71 MI TTOM3J0 DMWDV71 MN Estrogen receptor beta (ESR2) DMWDV71 MT DTT DMWDV71 MA Inhibitor DMWDV71 RN Design and synthesis of aryl diphenolic azoles as potent and selective estrogen receptor-beta ligands. J Med Chem. 2004 Oct 7;47(21):5021-40. DMWDV71 RU https://pubmed.ncbi.nlm.nih.gov/15456246 DMG6ABE DI DMG6ABE DMG6ABE DN 2-(2-Chloro-benzoyl)-cyclohexane-1,3-dione DMG6ABE MI TT8DSFC DMG6ABE MN Hydroxyphenylpyruvate dioxygenase (HPD) DMG6ABE MT DTT DMG6ABE MA Inhibitor DMG6ABE RN SAR studies of 2-o-substituted-benzoyl- and 2-alkanoyl-cyclohexane-1,3-diones as inhibitors of 4-hydroxyphenylpyruvate dioxygenase. Bioorg Med Chem Lett. 2000 May 1;10(9):843-5. DMG6ABE RU https://pubmed.ncbi.nlm.nih.gov/10853644 DM1ULEX DI DM1ULEX DM1ULEX DN 2-(2-chlorophenoxy)-3-(piperidin-4-yl)pyridine DM1ULEX MI TTSQIFT DM1ULEX MN 5-HT 1A receptor (HTR1A) DM1ULEX MT DTT DM1ULEX MA Inhibitor DM1ULEX RN Design, synthesis, and pharmacological evaluation of phenoxy pyridyl derivatives as dual norepinephrine reuptake inhibitors and 5-HT1A partial agon... Bioorg Med Chem Lett. 2010 Feb 1;20(3):1114-7. DM1ULEX RU https://pubmed.ncbi.nlm.nih.gov/20031410 DM1ULEX DI DM1ULEX DM1ULEX DN 2-(2-chlorophenoxy)-3-(piperidin-4-yl)pyridine DM1ULEX MI TTVBI8W DM1ULEX MN Dopamine transporter (DAT) DM1ULEX MT DTT DM1ULEX MA Inhibitor DM1ULEX RN Design, synthesis, and pharmacological evaluation of phenoxy pyridyl derivatives as dual norepinephrine reuptake inhibitors and 5-HT1A partial agon... Bioorg Med Chem Lett. 2010 Feb 1;20(3):1114-7. DM1ULEX RU https://pubmed.ncbi.nlm.nih.gov/20031410 DM1ULEX DI DM1ULEX DM1ULEX DN 2-(2-chlorophenoxy)-3-(piperidin-4-yl)pyridine DM1ULEX MI TTAWNKZ DM1ULEX MN Norepinephrine transporter (NET) DM1ULEX MT DTT DM1ULEX MA Inhibitor DM1ULEX RN Design, synthesis, and pharmacological evaluation of phenoxy pyridyl derivatives as dual norepinephrine reuptake inhibitors and 5-HT1A partial agon... Bioorg Med Chem Lett. 2010 Feb 1;20(3):1114-7. DM1ULEX RU https://pubmed.ncbi.nlm.nih.gov/20031410 DM1ULEX DI DM1ULEX DM1ULEX DN 2-(2-chlorophenoxy)-3-(piperidin-4-yl)pyridine DM1ULEX MI TT3ROYC DM1ULEX MN Serotonin transporter (SERT) DM1ULEX MT DTT DM1ULEX MA Inhibitor DM1ULEX RN Design, synthesis, and pharmacological evaluation of phenoxy pyridyl derivatives as dual norepinephrine reuptake inhibitors and 5-HT1A partial agon... Bioorg Med Chem Lett. 2010 Feb 1;20(3):1114-7. DM1ULEX RU https://pubmed.ncbi.nlm.nih.gov/20031410 DM60RWZ DI DM60RWZ DM60RWZ DN 2-(2-chlorophenyl)-2,2-diphenylethanamide DM60RWZ MI TTMNI76 DM60RWZ MN Calcium-activated potassium channel (KCN) DM60RWZ MT DTT DM60RWZ MA Inhibitor DM60RWZ RN Novel inhibitors of the Gardos channel for the treatment of sickle cell disease. J Med Chem. 2008 Feb 28;51(4):976-82. DM60RWZ RU https://pubmed.ncbi.nlm.nih.gov/18232633 DMTYDX2 DI DMTYDX2 DMTYDX2 DN 2-(2-Chlorophenyl)-2H-indazole-7-carboxamide DMTYDX2 MI TTVDSZ0 DMTYDX2 MN Poly [ADP-ribose] polymerase 1 (PARP1) DMTYDX2 MT DTT DMTYDX2 MA Inhibitor DMTYDX2 RN Discovery of 2-{4-[(3S)-piperidin-3-yl]phenyl}-2H-indazole-7-carboxamide (MK-4827): a novel oral poly(ADP-ribose)polymerase (PARP) inhibitor effica... J Med Chem. 2009 Nov 26;52(22):7170-85. DMTYDX2 RU https://pubmed.ncbi.nlm.nih.gov/19873981 DMFG2S5 DI DMFG2S5 DMFG2S5 DN 2-(2-chlorophenyl)-2-morpholinoethanamine DMFG2S5 MI TTDIGC1 DMFG2S5 MN Dipeptidyl peptidase 4 (DPP-4) DMFG2S5 MT DTT DMFG2S5 MA Inhibitor DMFG2S5 RN In silico fragment-based discovery of DPP-IV S1 pocket binders. Bioorg Med Chem Lett. 2006 Mar 1;16(5):1405-9. DMFG2S5 RU https://pubmed.ncbi.nlm.nih.gov/16321524 DMJ38LE DI DMJ38LE DMJ38LE DN 2-(2-chlorophenylamino)-5-methylthiazol-4(5H)-one DMJ38LE MI TTN7BL9 DMJ38LE MN Corticosteroid 11-beta-dehydrogenase 1 (HSD11B1) DMJ38LE MT DTT DMJ38LE MA Inhibitor DMJ38LE RN The discovery of 2-anilinothiazolones as 11beta-HSD1 inhibitors. Bioorg Med Chem Lett. 2007 Nov 15;17(22):6056-61. DMJ38LE RU https://pubmed.ncbi.nlm.nih.gov/17919905 DM187UQ DI DM187UQ DM187UQ DN 2-(2-cycloheptylidenehydrazinyl)-4-phenylthiazole DM187UQ MI TT3WG5C DM187UQ MN Monoamine oxidase type A (MAO-A) DM187UQ MT DTT DM187UQ MA Inhibitor DM187UQ RN Synthesis, semipreparative HPLC separation, biological evaluation, and 3D-QSAR of hydrazothiazole derivatives as human monoamine oxidase B inhibitors. Bioorg Med Chem. 2010 Jul 15;18(14):5063-70. DM187UQ RU https://pubmed.ncbi.nlm.nih.gov/20579890 DM187UQ DI DM187UQ DM187UQ DN 2-(2-cycloheptylidenehydrazinyl)-4-phenylthiazole DM187UQ MI TTGP7BY DM187UQ MN Monoamine oxidase type B (MAO-B) DM187UQ MT DTT DM187UQ MA Inhibitor DM187UQ RN Synthesis, semipreparative HPLC separation, biological evaluation, and 3D-QSAR of hydrazothiazole derivatives as human monoamine oxidase B inhibitors. Bioorg Med Chem. 2010 Jul 15;18(14):5063-70. DM187UQ RU https://pubmed.ncbi.nlm.nih.gov/20579890 DMUN2CS DI DMUN2CS DMUN2CS DN 2-(2-cyclohexyl-4-fluorophenoxy)acetic acid DMUN2CS MI TTQDMX5 DMUN2CS MN Prostaglandin D2 receptor 2 (PTGDR2) DMUN2CS MT DTT DMUN2CS MA Inhibitor DMUN2CS RN 2-Cycloalkyl phenoxyacetic acid CRTh2 receptor antagonists. Bioorg Med Chem Lett. 2007 Aug 1;17(15):4347-50. DMUN2CS RU https://pubmed.ncbi.nlm.nih.gov/17531480 DMSI07M DI DMSI07M DMSI07M DN 2-(2-cyclohexyl-4-methoxyphenoxy)acetic acid DMSI07M MI TTQDMX5 DMSI07M MN Prostaglandin D2 receptor 2 (PTGDR2) DMSI07M MT DTT DMSI07M MA Inhibitor DMSI07M RN 2-Cycloalkyl phenoxyacetic acid CRTh2 receptor antagonists. Bioorg Med Chem Lett. 2007 Aug 1;17(15):4347-50. DMSI07M RU https://pubmed.ncbi.nlm.nih.gov/17531480 DMVCY42 DI DMVCY42 DMVCY42 DN 2-(2-cyclohexyl-4-methylphenoxy)acetic acid DMVCY42 MI TTQDMX5 DMVCY42 MN Prostaglandin D2 receptor 2 (PTGDR2) DMVCY42 MT DTT DMVCY42 MA Inhibitor DMVCY42 RN 2-Cycloalkyl phenoxyacetic acid CRTh2 receptor antagonists. Bioorg Med Chem Lett. 2007 Aug 1;17(15):4347-50. DMVCY42 RU https://pubmed.ncbi.nlm.nih.gov/17531480 DMPNGXE DI DMPNGXE DMPNGXE DN 2-(2-cyclohexylidenehydrazinyl)-4-phenylthiazole DMPNGXE MI TTGP7BY DMPNGXE MN Monoamine oxidase type B (MAO-B) DMPNGXE MT DTT DMPNGXE MA Inhibitor DMPNGXE RN Synthesis, semipreparative HPLC separation, biological evaluation, and 3D-QSAR of hydrazothiazole derivatives as human monoamine oxidase B inhibitors. Bioorg Med Chem. 2010 Jul 15;18(14):5063-70. DMPNGXE RU https://pubmed.ncbi.nlm.nih.gov/20579890 DMTFWAQ DI DMTFWAQ DMTFWAQ DN 2-(2-cyclohexylidenehydrazinyl)-4-p-tolylthiazole DMTFWAQ MI TTGP7BY DMTFWAQ MN Monoamine oxidase type B (MAO-B) DMTFWAQ MT DTT DMTFWAQ MA Inhibitor DMTFWAQ RN Synthesis, semipreparative HPLC separation, biological evaluation, and 3D-QSAR of hydrazothiazole derivatives as human monoamine oxidase B inhibitors. Bioorg Med Chem. 2010 Jul 15;18(14):5063-70. DMTFWAQ RU https://pubmed.ncbi.nlm.nih.gov/20579890 DM81WJK DI DM81WJK DM81WJK DN 2-(2-cyclohexylphenoxy)acetic acid DM81WJK MI TTQDMX5 DM81WJK MN Prostaglandin D2 receptor 2 (PTGDR2) DM81WJK MT DTT DM81WJK MA Inhibitor DM81WJK RN 2-Cycloalkyl phenoxyacetic acid CRTh2 receptor antagonists. Bioorg Med Chem Lett. 2007 Aug 1;17(15):4347-50. DM81WJK RU https://pubmed.ncbi.nlm.nih.gov/17531480 DMH1VCE DI DMH1VCE DMH1VCE DN 2-(2-cyclopentylidenehydrazinyl)-4-phenylthiazole DMH1VCE MI TT3WG5C DMH1VCE MN Monoamine oxidase type A (MAO-A) DMH1VCE MT DTT DMH1VCE MA Inhibitor DMH1VCE RN Synthesis, semipreparative HPLC separation, biological evaluation, and 3D-QSAR of hydrazothiazole derivatives as human monoamine oxidase B inhibitors. Bioorg Med Chem. 2010 Jul 15;18(14):5063-70. DMH1VCE RU https://pubmed.ncbi.nlm.nih.gov/20579890 DMH1VCE DI DMH1VCE DMH1VCE DN 2-(2-cyclopentylidenehydrazinyl)-4-phenylthiazole DMH1VCE MI TTGP7BY DMH1VCE MN Monoamine oxidase type B (MAO-B) DMH1VCE MT DTT DMH1VCE MA Inhibitor DMH1VCE RN Synthesis, semipreparative HPLC separation, biological evaluation, and 3D-QSAR of hydrazothiazole derivatives as human monoamine oxidase B inhibitors. Bioorg Med Chem. 2010 Jul 15;18(14):5063-70. DMH1VCE RU https://pubmed.ncbi.nlm.nih.gov/20579890 DM1SN37 DI DM1SN37 DM1SN37 DN 2-(2-fluorophenoxy)-3-(piperidin-4-yl)pyridine DM1SN37 MI TTSQIFT DM1SN37 MN 5-HT 1A receptor (HTR1A) DM1SN37 MT DTT DM1SN37 MA Inhibitor DM1SN37 RN Design, synthesis, and pharmacological evaluation of phenoxy pyridyl derivatives as dual norepinephrine reuptake inhibitors and 5-HT1A partial agon... Bioorg Med Chem Lett. 2010 Feb 1;20(3):1114-7. DM1SN37 RU https://pubmed.ncbi.nlm.nih.gov/20031410 DM1SN37 DI DM1SN37 DM1SN37 DN 2-(2-fluorophenoxy)-3-(piperidin-4-yl)pyridine DM1SN37 MI TTAWNKZ DM1SN37 MN Norepinephrine transporter (NET) DM1SN37 MT DTT DM1SN37 MA Inhibitor DM1SN37 RN Design, synthesis, and pharmacological evaluation of phenoxy pyridyl derivatives as dual norepinephrine reuptake inhibitors and 5-HT1A partial agon... Bioorg Med Chem Lett. 2010 Feb 1;20(3):1114-7. DM1SN37 RU https://pubmed.ncbi.nlm.nih.gov/20031410 DM1SN37 DI DM1SN37 DM1SN37 DN 2-(2-fluorophenoxy)-3-(piperidin-4-yl)pyridine DM1SN37 MI TT3ROYC DM1SN37 MN Serotonin transporter (SERT) DM1SN37 MT DTT DM1SN37 MA Inhibitor DM1SN37 RN Design, synthesis, and pharmacological evaluation of phenoxy pyridyl derivatives as dual norepinephrine reuptake inhibitors and 5-HT1A partial agon... Bioorg Med Chem Lett. 2010 Feb 1;20(3):1114-7. DM1SN37 RU https://pubmed.ncbi.nlm.nih.gov/20031410 DMDUG9M DI DMDUG9M DMDUG9M DN 2-(2-Fluoro-phenyl)-benzo[h]chromen-4-one DMDUG9M MI TTK3PY9 DMDUG9M MN DNA-dependent protein kinase catalytic (PRKDC) DMDUG9M MT DTT DMDUG9M MA Inhibitor DMDUG9M RN Selective benzopyranone and pyrimido[2,1-a]isoquinolin-4-one inhibitors of DNA-dependent protein kinase: synthesis, structure-activity studies, and... J Med Chem. 2005 Jan 27;48(2):569-85. DMDUG9M RU https://pubmed.ncbi.nlm.nih.gov/15658870 DMMEBH3 DI DMMEBH3 DMMEBH3 DN 2-(2-formylphenoxy)acetic acid DMMEBH3 MI TTQDMX5 DMMEBH3 MN Prostaglandin D2 receptor 2 (PTGDR2) DMMEBH3 MT DTT DMMEBH3 MA Inhibitor DMMEBH3 RN Novel selective orally active CRTH2 antagonists for allergic inflammation developed from in silico derived hits. J Med Chem. 2006 Nov 16;49(23):6638-41. DMMEBH3 RU https://pubmed.ncbi.nlm.nih.gov/17154491 DMXGWOT DI DMXGWOT DMXGWOT DN 2-(2-furyl)-6-(1H-pyrazol-1-yl)pyrimidin-4-amine DMXGWOT MI TTK25J1 DMXGWOT MN Adenosine A1 receptor (ADORA1) DMXGWOT MT DTT DMXGWOT MA Inhibitor DMXGWOT RN Identification of novel, water-soluble, 2-amino-N-pyrimidin-4-yl acetamides as A2A receptor antagonists with in vivo efficacy. J Med Chem. 2008 Feb 14;51(3):400-6. DMXGWOT RU https://pubmed.ncbi.nlm.nih.gov/18189346 DMXGWOT DI DMXGWOT DMXGWOT DN 2-(2-furyl)-6-(1H-pyrazol-1-yl)pyrimidin-4-amine DMXGWOT MI TTM2AOE DMXGWOT MN Adenosine A2a receptor (ADORA2A) DMXGWOT MT DTT DMXGWOT MA Inhibitor DMXGWOT RN Identification of novel, water-soluble, 2-amino-N-pyrimidin-4-yl acetamides as A2A receptor antagonists with in vivo efficacy. J Med Chem. 2008 Feb 14;51(3):400-6. DMXGWOT RU https://pubmed.ncbi.nlm.nih.gov/18189346 DMSI41E DI DMSI41E DMSI41E DN 2-(2-hexylphenyl)isoindoline-1,3-dione DMSI41E MI TTECBXN DMSI41E MN Oxysterols receptor LXR-alpha (NR1H3) DMSI41E MT DTT DMSI41E MA Inhibitor DMSI41E RN Co-existence of alpha-glucosidase-inhibitory and liver X receptor-regulatory activities and their separation by structural development. Bioorg Med Chem. 2008 Apr 15;16(8):4272-85. DMSI41E RU https://pubmed.ncbi.nlm.nih.gov/18343126 DMMEL39 DI DMMEL39 DMMEL39 DN 2-(2-Hydroxycarbamoyl-ethyl)-pentanedioic acid DMMEL39 MI TT9G4N0 DMMEL39 MN Glutamate carboxypeptidase II (GCPII) DMMEL39 MT DTT DMMEL39 MA Inhibitor DMMEL39 RN Synthesis and biological evaluation of hydroxamate-Based inhibitors of glutamate carboxypeptidase II. Bioorg Med Chem Lett. 2003 Jul 7;13(13):2097-100. DMMEL39 RU https://pubmed.ncbi.nlm.nih.gov/12798312 DMRPCL7 DI DMRPCL7 DMRPCL7 DN 2-(2-Hydroxyethyl)anthra[1,9-cd]pyrazol-6(2H)-one DMRPCL7 MI TT0IHXV DMRPCL7 MN DNA topoisomerase II (TOP2) DMRPCL7 MT DTT DMRPCL7 MA Inhibitor DMRPCL7 RN Design, synthesis and biological evaluation of a novel series of anthrapyrazoles linked with netropsin-like oligopyrrole carboxamides as anticancer... Bioorg Med Chem. 2010 Jun 1;18(11):3974-84. DMRPCL7 RU https://pubmed.ncbi.nlm.nih.gov/20471276 DM3UMYD DI DM3UMYD DM3UMYD DN 2-(2-Hydroxy-phenyl)-1H-indole-5-carboxamidine DM3UMYD MI TT2WR1T DM3UMYD MN Cationic trypsinogen (PRSS1) DM3UMYD MT DTT DM3UMYD MA Inhibitor DM3UMYD RN Development of serine protease inhibitors displaying a multicentered short (<2.3 A) hydrogen bond binding mode: inhibitors of urokinase-type plasmi... J Med Chem. 2001 Aug 16;44(17):2753-71. DM3UMYD RU https://pubmed.ncbi.nlm.nih.gov/11495587 DM3UMYD DI DM3UMYD DM3UMYD DN 2-(2-Hydroxy-phenyl)-1H-indole-5-carboxamidine DM3UMYD MI TT6L509 DM3UMYD MN Coagulation factor IIa (F2) DM3UMYD MT DTT DM3UMYD MA Inhibitor DM3UMYD RN Development of serine protease inhibitors displaying a multicentered short (<2.3 A) hydrogen bond binding mode: inhibitors of urokinase-type plasmi... J Med Chem. 2001 Aug 16;44(17):2753-71. DM3UMYD RU https://pubmed.ncbi.nlm.nih.gov/11495587 DM3UMYD DI DM3UMYD DM3UMYD DN 2-(2-Hydroxy-phenyl)-1H-indole-5-carboxamidine DM3UMYD MI TTP86E2 DM3UMYD MN Plasminogen (PLG) DM3UMYD MT DTT DM3UMYD MA Inhibitor DM3UMYD RN Development of serine protease inhibitors displaying a multicentered short (<2.3 A) hydrogen bond binding mode: inhibitors of urokinase-type plasmi... J Med Chem. 2001 Aug 16;44(17):2753-71. DM3UMYD RU https://pubmed.ncbi.nlm.nih.gov/11495587 DM3UMYD DI DM3UMYD DM3UMYD DN 2-(2-Hydroxy-phenyl)-1H-indole-5-carboxamidine DM3UMYD MI TTXAGYU DM3UMYD MN Tissue-type plasminogen activator (PLAT) DM3UMYD MT DTT DM3UMYD MA Inhibitor DM3UMYD RN Development of serine protease inhibitors displaying a multicentered short (<2.3 A) hydrogen bond binding mode: inhibitors of urokinase-type plasmi... J Med Chem. 2001 Aug 16;44(17):2753-71. DM3UMYD RU https://pubmed.ncbi.nlm.nih.gov/11495587 DM3UMYD DI DM3UMYD DM3UMYD DN 2-(2-Hydroxy-phenyl)-1H-indole-5-carboxamidine DM3UMYD MI TTGY7WI DM3UMYD MN Urokinase-type plasminogen activator (PLAU) DM3UMYD MT DTT DM3UMYD MA Inhibitor DM3UMYD RN Development of serine protease inhibitors displaying a multicentered short (<2.3 A) hydrogen bond binding mode: inhibitors of urokinase-type plasmi... J Med Chem. 2001 Aug 16;44(17):2753-71. DM3UMYD RU https://pubmed.ncbi.nlm.nih.gov/11495587 DMOANXP DI DMOANXP DMOANXP DN 2-(2-Hydroxy-phenyl)-6-methyl-chromen-4-one DMOANXP MI TTNJYV2 DMOANXP MN Gamma-aminobutyric acid receptor (GAR) DMOANXP MT DTT DMOANXP MA Inhibitor DMOANXP RN Refinement and evaluation of a pharmacophore model for flavone derivatives binding to the benzodiazepine site of the GABA(A) receptor. J Med Chem. 2002 Sep 12;45(19):4188-201. DMOANXP RU https://pubmed.ncbi.nlm.nih.gov/12213060 DMCLIN8 DI DMCLIN8 DMCLIN8 DN 2-(2''-indolylethyloxy)adenosine DMCLIN8 MI TTK25J1 DMCLIN8 MN Adenosine A1 receptor (ADORA1) DMCLIN8 MT DTT DMCLIN8 MA Inhibitor DMCLIN8 RN Structure-activity relationships of 2,N(6),5'-substituted adenosine derivatives with potent activity at the A2B adenosine receptor. J Med Chem. 2007 Apr 19;50(8):1810-27. DMCLIN8 RU https://pubmed.ncbi.nlm.nih.gov/17378544 DMCLIN8 DI DMCLIN8 DMCLIN8 DN 2-(2''-indolylethyloxy)adenosine DMCLIN8 MI TTM2AOE DMCLIN8 MN Adenosine A2a receptor (ADORA2A) DMCLIN8 MT DTT DMCLIN8 MA Inhibitor DMCLIN8 RN Structure-activity relationships of 2,N(6),5'-substituted adenosine derivatives with potent activity at the A2B adenosine receptor. J Med Chem. 2007 Apr 19;50(8):1810-27. DMCLIN8 RU https://pubmed.ncbi.nlm.nih.gov/17378544 DMCLIN8 DI DMCLIN8 DMCLIN8 DN 2-(2''-indolylethyloxy)adenosine DMCLIN8 MI TTJFY5U DMCLIN8 MN Adenosine A3 receptor (ADORA3) DMCLIN8 MT DTT DMCLIN8 MA Inhibitor DMCLIN8 RN Structure-activity relationships of 2,N(6),5'-substituted adenosine derivatives with potent activity at the A2B adenosine receptor. J Med Chem. 2007 Apr 19;50(8):1810-27. DMCLIN8 RU https://pubmed.ncbi.nlm.nih.gov/17378544 DMSVHU9 DI DMSVHU9 DMSVHU9 DN 2-(2-Iodo-benzoyl)-cyclohexane-1,3-dione DMSVHU9 MI TT8DSFC DMSVHU9 MN Hydroxyphenylpyruvate dioxygenase (HPD) DMSVHU9 MT DTT DMSVHU9 MA Inhibitor DMSVHU9 RN SAR studies of 2-o-substituted-benzoyl- and 2-alkanoyl-cyclohexane-1,3-diones as inhibitors of 4-hydroxyphenylpyruvate dioxygenase. Bioorg Med Chem Lett. 2000 May 1;10(9):843-5. DMSVHU9 RU https://pubmed.ncbi.nlm.nih.gov/10853644 DMPA4S0 DI DMPA4S0 DMPA4S0 DN 2-(2-Iodo-phenyl)-benzo[d][1,3]oxazin-4-one DMPA4S0 MI TT2WR1T DMPA4S0 MN Cationic trypsinogen (PRSS1) DMPA4S0 MT DTT DMPA4S0 MA Inhibitor DMPA4S0 RN 2-amino-4H-3,1-benzoxazin-4-ones as inhibitors of C1r serine protease. J Med Chem. 1998 Mar 26;41(7):1060-7. DMPA4S0 RU https://pubmed.ncbi.nlm.nih.gov/9544206 DMGELY0 DI DMGELY0 DMGELY0 DN 2-(2-Mercapto-ethyl)-pentanedioic acid DMGELY0 MI TT9G4N0 DMGELY0 MN Glutamate carboxypeptidase II (GCPII) DMGELY0 MT DTT DMGELY0 MA Inhibitor DMGELY0 RN Synthesis and biological evaluation of thiol-based inhibitors of glutamate carboxypeptidase II: discovery of an orally active GCP II inhibitor. J Med Chem. 2003 May 8;46(10):1989-96. DMGELY0 RU https://pubmed.ncbi.nlm.nih.gov/12723961 DMESMBO DI DMESMBO DMESMBO DN 2-(2-Methoxy-benzoyl)-cyclohexane-1,3-dione DMESMBO MI TT8DSFC DMESMBO MN Hydroxyphenylpyruvate dioxygenase (HPD) DMESMBO MT DTT DMESMBO MA Inhibitor DMESMBO RN SAR studies of 2-o-substituted-benzoyl- and 2-alkanoyl-cyclohexane-1,3-diones as inhibitors of 4-hydroxyphenylpyruvate dioxygenase. Bioorg Med Chem Lett. 2000 May 1;10(9):843-5. DMESMBO RU https://pubmed.ncbi.nlm.nih.gov/10853644 DM9Z8V5 DI DM9Z8V5 DM9Z8V5 DN 2-(2-Methoxybenzyl)-3H-benzo[f]chromen-3-one DM9Z8V5 MI TTMSFAW DM9Z8V5 MN Cannabinoid receptor 2 (CB2) DM9Z8V5 MT DTT DM9Z8V5 MA Inhibitor DM9Z8V5 RN Synthesis and pharmacological evaluation of coumarin derivatives as cannabinoid receptor antagonists and inverse agonists. Bioorg Med Chem. 2009 Apr 1;17(7):2842-51. DM9Z8V5 RU https://pubmed.ncbi.nlm.nih.gov/19278853 DMYVDJQ DI DMYVDJQ DMYVDJQ DN 2-(2-methoxyphenoxy)-3-(piperidin-4-yl)pyridine DMYVDJQ MI TTSQIFT DMYVDJQ MN 5-HT 1A receptor (HTR1A) DMYVDJQ MT DTT DMYVDJQ MA Inhibitor DMYVDJQ RN Design, synthesis, and pharmacological evaluation of phenoxy pyridyl derivatives as dual norepinephrine reuptake inhibitors and 5-HT1A partial agon... Bioorg Med Chem Lett. 2010 Feb 1;20(3):1114-7. DMYVDJQ RU https://pubmed.ncbi.nlm.nih.gov/20031410 DMYVDJQ DI DMYVDJQ DMYVDJQ DN 2-(2-methoxyphenoxy)-3-(piperidin-4-yl)pyridine DMYVDJQ MI TTVBI8W DMYVDJQ MN Dopamine transporter (DAT) DMYVDJQ MT DTT DMYVDJQ MA Inhibitor DMYVDJQ RN Design, synthesis, and pharmacological evaluation of phenoxy pyridyl derivatives as dual norepinephrine reuptake inhibitors and 5-HT1A partial agon... Bioorg Med Chem Lett. 2010 Feb 1;20(3):1114-7. DMYVDJQ RU https://pubmed.ncbi.nlm.nih.gov/20031410 DMYVDJQ DI DMYVDJQ DMYVDJQ DN 2-(2-methoxyphenoxy)-3-(piperidin-4-yl)pyridine DMYVDJQ MI TTAWNKZ DMYVDJQ MN Norepinephrine transporter (NET) DMYVDJQ MT DTT DMYVDJQ MA Inhibitor DMYVDJQ RN Design, synthesis, and pharmacological evaluation of phenoxy pyridyl derivatives as dual norepinephrine reuptake inhibitors and 5-HT1A partial agon... Bioorg Med Chem Lett. 2010 Feb 1;20(3):1114-7. DMYVDJQ RU https://pubmed.ncbi.nlm.nih.gov/20031410 DMYVDJQ DI DMYVDJQ DMYVDJQ DN 2-(2-methoxyphenoxy)-3-(piperidin-4-yl)pyridine DMYVDJQ MI TT3ROYC DMYVDJQ MN Serotonin transporter (SERT) DMYVDJQ MT DTT DMYVDJQ MA Inhibitor DMYVDJQ RN Design, synthesis, and pharmacological evaluation of phenoxy pyridyl derivatives as dual norepinephrine reuptake inhibitors and 5-HT1A partial agon... Bioorg Med Chem Lett. 2010 Feb 1;20(3):1114-7. DMYVDJQ RU https://pubmed.ncbi.nlm.nih.gov/20031410 DMXFYN8 DI DMXFYN8 DMXFYN8 DN 2-(2-methoxyphenyl)-1H-indene DMXFYN8 MI TT8NGED DMXFYN8 MN Prostaglandin G/H synthase 1 (COX-1) DMXFYN8 MT DTT DMXFYN8 MA Inhibitor DMXFYN8 RN 'Bridged' stilbene derivatives as selective cyclooxygenase-1 inhibitors. Bioorg Med Chem. 2007 Sep 15;15(18):6109-18. DMXFYN8 RU https://pubmed.ncbi.nlm.nih.gov/17604631 DMDI98B DI DMDI98B DMDI98B DN 2-(2-Methoxy-phenyl)-1-methyl-ethylamine DMDI98B MI TTSQIFT DMDI98B MN 5-HT 1A receptor (HTR1A) DMDI98B MT DTT DMDI98B MA Inhibitor DMDI98B RN 5-HT1 and 5-HT2 binding characteristics of 1-(2,5-dimethoxy-4-bromophenyl)-2-aminopropane analogues. J Med Chem. 1986 Feb;29(2):194-9. DMDI98B RU https://pubmed.ncbi.nlm.nih.gov/3950904 DMDI98B DI DMDI98B DMDI98B DN 2-(2-Methoxy-phenyl)-1-methyl-ethylamine DMDI98B MI TT6MSOK DMDI98B MN 5-HT 1D receptor (HTR1D) DMDI98B MT DTT DMDI98B MA Inhibitor DMDI98B RN 5-HT1 and 5-HT2 binding characteristics of 1-(2,5-dimethoxy-4-bromophenyl)-2-aminopropane analogues. J Med Chem. 1986 Feb;29(2):194-9. DMDI98B RU https://pubmed.ncbi.nlm.nih.gov/3950904 DMDI98B DI DMDI98B DMDI98B DN 2-(2-Methoxy-phenyl)-1-methyl-ethylamine DMDI98B MI TTJQOD7 DMDI98B MN 5-HT 2A receptor (HTR2A) DMDI98B MT DTT DMDI98B MA Inhibitor DMDI98B RN 5-HT1 and 5-HT2 binding characteristics of 1-(2,5-dimethoxy-4-bromophenyl)-2-aminopropane analogues. J Med Chem. 1986 Feb;29(2):194-9. DMDI98B RU https://pubmed.ncbi.nlm.nih.gov/3950904 DMPVCDN DI DMPVCDN DMPVCDN DN 2-(2-Methoxy-phenyl)-6-methyl-chromen-4-one DMPVCDN MI TTNJYV2 DMPVCDN MN Gamma-aminobutyric acid receptor (GAR) DMPVCDN MT DTT DMPVCDN MA Inhibitor DMPVCDN RN Refinement and evaluation of a pharmacophore model for flavone derivatives binding to the benzodiazepine site of the GABA(A) receptor. J Med Chem. 2002 Sep 12;45(19):4188-201. DMPVCDN RU https://pubmed.ncbi.nlm.nih.gov/12213060 DMXVCL0 DI DMXVCL0 DMXVCL0 DN 2-(2-methoxyphenyl)-6-morpholino-4H-pyran-4-one DMXVCL0 MI TTK3PY9 DMXVCL0 MN DNA-dependent protein kinase catalytic (PRKDC) DMXVCL0 MT DTT DMXVCL0 MA Inhibitor DMXVCL0 RN Pyranone, thiopyranone, and pyridone inhibitors of phosphatidylinositol 3-kinase related kinases. Structure-activity relationships for DNA-dependen... J Med Chem. 2007 Apr 19;50(8):1958-72. DMXVCL0 RU https://pubmed.ncbi.nlm.nih.gov/17371003 DM4GN0E DI DM4GN0E DM4GN0E DN 2-(2-Methyl-benzoyl)-cyclohexane-1,3-dione DM4GN0E MI TT8DSFC DM4GN0E MN Hydroxyphenylpyruvate dioxygenase (HPD) DM4GN0E MT DTT DM4GN0E MA Inhibitor DM4GN0E RN SAR studies of 2-o-substituted-benzoyl- and 2-alkanoyl-cyclohexane-1,3-diones as inhibitors of 4-hydroxyphenylpyruvate dioxygenase. Bioorg Med Chem Lett. 2000 May 1;10(9):843-5. DM4GN0E RU https://pubmed.ncbi.nlm.nih.gov/10853644 DM7HN4Z DI DM7HN4Z DM7HN4Z DN 2-(2'-methyl-biphenyl-3-yl)-ethylamine DM7HN4Z MI TTSQIFT DM7HN4Z MN 5-HT 1A receptor (HTR1A) DM7HN4Z MT DTT DM7HN4Z MA Inhibitor DM7HN4Z RN Novel aminoethylbiphenyls as 5-HT7 receptor ligands. Bioorg Med Chem Lett. 2007 Jun 1;17(11):3018-22. DM7HN4Z RU https://pubmed.ncbi.nlm.nih.gov/17419056 DM7HN4Z DI DM7HN4Z DM7HN4Z DN 2-(2'-methyl-biphenyl-3-yl)-ethylamine DM7HN4Z MI TTO9X1H DM7HN4Z MN 5-HT 7 receptor (HTR7) DM7HN4Z MT DTT DM7HN4Z MA Inhibitor DM7HN4Z RN Novel aminoethylbiphenyls as 5-HT7 receptor ligands. Bioorg Med Chem Lett. 2007 Jun 1;17(11):3018-22. DM7HN4Z RU https://pubmed.ncbi.nlm.nih.gov/17419056 DMAHZR9 DI DMAHZR9 DMAHZR9 DN 2-(2-Methyl-morpholin-4-yl)-benzo[h]chromen-4-one DMAHZR9 MI TTK3PY9 DMAHZR9 MN DNA-dependent protein kinase catalytic (PRKDC) DMAHZR9 MT DTT DMAHZR9 MA Inhibitor DMAHZR9 RN Identification of a highly potent and selective DNA-dependent protein kinase (DNA-PK) inhibitor (NU7441) by screening of chromenone libraries. Bioorg Med Chem Lett. 2004 Dec 20;14(24):6083-7. DMAHZR9 RU https://pubmed.ncbi.nlm.nih.gov/15546735 DMAHZR9 DI DMAHZR9 DMAHZR9 DN 2-(2-Methyl-morpholin-4-yl)-benzo[h]chromen-4-one DMAHZR9 MI TTCJG29 DMAHZR9 MN Serine/threonine-protein kinase mTOR (mTOR) DMAHZR9 MT DTT DMAHZR9 MA Inhibitor DMAHZR9 RN Selective benzopyranone and pyrimido[2,1-a]isoquinolin-4-one inhibitors of DNA-dependent protein kinase: synthesis, structure-activity studies, and... J Med Chem. 2005 Jan 27;48(2):569-85. DMAHZR9 RU https://pubmed.ncbi.nlm.nih.gov/15658870 DMPH63G DI DMPH63G DMPH63G DN 2-(2-Methylpropanoyl)-1,3,5-benzenetriol DMPH63G MI TT8NGED DMPH63G MN Prostaglandin G/H synthase 1 (COX-1) DMPH63G MT DTT DMPH63G MA Inhibitor DMPH63G RN Anti-inflammatory acylphloroglucinol derivatives from Hops (Humulus lupulus). J Nat Prod. 2005 Oct;68(10):1545-8. DMPH63G RU https://pubmed.ncbi.nlm.nih.gov/16252923 DMW75IF DI DMW75IF DMW75IF DN 2-(2-methylquinolin-4-ylamino)-N-phenylacetamide DMW75IF MI TTQW87Y DMW75IF MN Opioid receptor kappa (OPRK1) DMW75IF MT DTT DMW75IF MA Inhibitor DMW75IF RN Synthesis and characterizations of novel quinoline derivatives having mixed ligand activities at the kappa and mu receptors: Potential therapeutic ... Bioorg Med Chem. 2009 Aug 15;17(16):5782-90. DMW75IF RU https://pubmed.ncbi.nlm.nih.gov/19640720 DMW75IF DI DMW75IF DMW75IF DN 2-(2-methylquinolin-4-ylamino)-N-phenylacetamide DMW75IF MI TTKWM86 DMW75IF MN Opioid receptor mu (MOP) DMW75IF MT DTT DMW75IF MA Inhibitor DMW75IF RN Synthesis and characterizations of novel quinoline derivatives having mixed ligand activities at the kappa and mu receptors: Potential therapeutic ... Bioorg Med Chem. 2009 Aug 15;17(16):5782-90. DMW75IF RU https://pubmed.ncbi.nlm.nih.gov/19640720 DMENUIH DI DMENUIH DMENUIH DN 2-(2-methylquinolin-7-yl)benzonitrile DMENUIH MI TTHS256 DMENUIH MN Metabotropic glutamate receptor 5 (mGluR5) DMENUIH MT DTT DMENUIH MA Inhibitor DMENUIH RN Rational design of 7-arylquinolines as non-competitive metabotropic glutamate receptor subtype 5 antagonists. Bioorg Med Chem Lett. 2007 Aug 15;17(16):4415-8. DMENUIH RU https://pubmed.ncbi.nlm.nih.gov/17590335 DMIHTL0 DI DMIHTL0 DMIHTL0 DN 2-(2-Methyl-thiazol-4-ylethynyl)-pyridine DMIHTL0 MI TTHS256 DMIHTL0 MN Metabotropic glutamate receptor 5 (mGluR5) DMIHTL0 MT DTT DMIHTL0 MA Inhibitor DMIHTL0 RN 5-[(2-Methyl-1,3-thiazol-4-yl)ethynyl]-2,3'-bipyridine: a highly potent, orally active metabotropic glutamate subtype 5 (mGlu5) receptor antagonist... Bioorg Med Chem Lett. 2004 Aug 2;14(15):3993-6. DMIHTL0 RU https://pubmed.ncbi.nlm.nih.gov/15225713 DMN176Y DI DMN176Y DMN176Y DN 2-(2-naphthamido)benzoic acid DMN176Y MI TT3PQ2Y DMN176Y MN Plasmodium Dihydroorotate dehydrogenase (Malaria DHOdehase) DMN176Y MT DTT DMN176Y MA Inhibitor DMN176Y RN The first de novo designed inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase. Bioorg Med Chem Lett. 2006 Jan 1;16(1):88-92. DMN176Y RU https://pubmed.ncbi.nlm.nih.gov/16236496 DMUJQX1 DI DMUJQX1 DMUJQX1 DN 2-(2-Nitro-benzoyl)-cyclohexane-1,3-dione DMUJQX1 MI TT8DSFC DMUJQX1 MN Hydroxyphenylpyruvate dioxygenase (HPD) DMUJQX1 MT DTT DMUJQX1 MA Inhibitor DMUJQX1 RN SAR studies of 2-o-substituted-benzoyl- and 2-alkanoyl-cyclohexane-1,3-diones as inhibitors of 4-hydroxyphenylpyruvate dioxygenase. Bioorg Med Chem Lett. 2000 May 1;10(9):843-5. DMUJQX1 RU https://pubmed.ncbi.nlm.nih.gov/10853644 DM5NLQE DI DM5NLQE DM5NLQE DN 2-(2-phenethylphenyl)isoindoline-1,3-dione DM5NLQE MI TTECBXN DM5NLQE MN Oxysterols receptor LXR-alpha (NR1H3) DM5NLQE MT DTT DM5NLQE MA Inhibitor DM5NLQE RN Separation of alpha-glucosidase-inhibitory and liver X receptor-antagonistic activities of phenethylphenyl phthalimide analogs and generation of LX... Bioorg Med Chem. 2009 Jul 15;17(14):5001-14. DM5NLQE RU https://pubmed.ncbi.nlm.nih.gov/19539483 DME0HPA DI DME0HPA DME0HPA DN 2-(2-phenoxypyrimidin-4-ylamino)benzoic acid DME0HPA MI TT0K6EO DME0HPA MN Stress-activated protein kinase JNK1 (JNK1) DME0HPA MT DTT DME0HPA MA Inhibitor DME0HPA RN Discovery of a new class of 4-anilinopyrimidines as potent c-Jun N-terminal kinase inhibitors: Synthesis and SAR studies. Bioorg Med Chem Lett. 2007 Feb 1;17(3):668-72. DME0HPA RU https://pubmed.ncbi.nlm.nih.gov/17107797 DM1K0U5 DI DM1K0U5 DM1K0U5 DN 2-(2-Phenyl-1H-indol-3-yl)-N,N-dipropyl-acetamide DM1K0U5 MI TTPTXIN DM1K0U5 MN Translocator protein (TSPO) DM1K0U5 MT DTT DM1K0U5 MA Inhibitor DM1K0U5 RN Chemistry, binding affinities, and behavioral properties of a new class of "antineophobic" mitochondrial DBI receptor complex (mDRC) ligands. J Med Chem. 1993 Oct 1;36(20):2908-20. DM1K0U5 RU https://pubmed.ncbi.nlm.nih.gov/8411007 DMO9SP1 DI DMO9SP1 DMO9SP1 DN 2-(2-phenyl-2-(piperazin-1-yl)ethyl)benzonitrile DMO9SP1 MI TTAWNKZ DMO9SP1 MN Norepinephrine transporter (NET) DMO9SP1 MT DTT DMO9SP1 MA Inhibitor DMO9SP1 RN N-(1,2-diphenylethyl)piperazines: a new class of dual serotonin/noradrenaline reuptake inhibitor. Bioorg Med Chem Lett. 2006 Aug 15;16(16):4345-8. DMO9SP1 RU https://pubmed.ncbi.nlm.nih.gov/16750359 DMO9SP1 DI DMO9SP1 DMO9SP1 DN 2-(2-phenyl-2-(piperazin-1-yl)ethyl)benzonitrile DMO9SP1 MI TT3ROYC DMO9SP1 MN Serotonin transporter (SERT) DMO9SP1 MT DTT DMO9SP1 MA Inhibitor DMO9SP1 RN N-(1,2-diphenylethyl)piperazines: a new class of dual serotonin/noradrenaline reuptake inhibitor. Bioorg Med Chem Lett. 2006 Aug 15;16(16):4345-8. DMO9SP1 RU https://pubmed.ncbi.nlm.nih.gov/16750359 DMQM6IA DI DMQM6IA DMQM6IA DN 2-(2-Phosphonooxy-ethyl)-pentanedioic acid DMQM6IA MI TT9G4N0 DMQM6IA MN Glutamate carboxypeptidase II (GCPII) DMQM6IA MT DTT DMQM6IA MA Inhibitor DMQM6IA RN Synthesis and biological evaluation of thiol-based inhibitors of glutamate carboxypeptidase II: discovery of an orally active GCP II inhibitor. J Med Chem. 2003 May 8;46(10):1989-96. DMQM6IA RU https://pubmed.ncbi.nlm.nih.gov/12723961 DMGVCKZ DI DMGVCKZ DMGVCKZ DN 2-(2-propoxypyrimidin-4-ylamino)benzoic acid DMGVCKZ MI TT0K6EO DMGVCKZ MN Stress-activated protein kinase JNK1 (JNK1) DMGVCKZ MT DTT DMGVCKZ MA Inhibitor DMGVCKZ RN Discovery of a new class of 4-anilinopyrimidines as potent c-Jun N-terminal kinase inhibitors: Synthesis and SAR studies. Bioorg Med Chem Lett. 2007 Feb 1;17(3):668-72. DMGVCKZ RU https://pubmed.ncbi.nlm.nih.gov/17107797 DMB4W68 DI DMB4W68 DMB4W68 DN 2-(2-sec-butoxypyrimidin-4-ylamino)benzoic acid DMB4W68 MI TT0K6EO DMB4W68 MN Stress-activated protein kinase JNK1 (JNK1) DMB4W68 MT DTT DMB4W68 MA Inhibitor DMB4W68 RN Discovery of a new class of 4-anilinopyrimidines as potent c-Jun N-terminal kinase inhibitors: Synthesis and SAR studies. Bioorg Med Chem Lett. 2007 Feb 1;17(3):668-72. DMB4W68 RU https://pubmed.ncbi.nlm.nih.gov/17107797 DMRL65E DI DMRL65E DMRL65E DN 2-(2-thiazolyl)ethanamine DMRL65E MI TTTIBOJ DMRL65E MN Histamine H1 receptor (H1R) DMRL65E MT DTT DMRL65E MA Agonist DMRL65E RN Multiple differences in agonist and antagonist pharmacology between human and guinea pig histamine H1-receptor. J Pharmacol Exp Ther. 2003 Jun;305(3):1104-15. DMRL65E RU https://pubmed.ncbi.nlm.nih.gov/12626648 DMLJH92 DI DMLJH92 DMLJH92 DN 2-(3-(2-methylquinolin-7-yl)phenyl)acetonitrile DMLJH92 MI TTHS256 DMLJH92 MN Metabotropic glutamate receptor 5 (mGluR5) DMLJH92 MT DTT DMLJH92 MA Inhibitor DMLJH92 RN Rational design of 7-arylquinolines as non-competitive metabotropic glutamate receptor subtype 5 antagonists. Bioorg Med Chem Lett. 2007 Aug 15;17(16):4415-8. DMLJH92 RU https://pubmed.ncbi.nlm.nih.gov/17590335 DMM9WB0 DI DMM9WB0 DMM9WB0 DN 2-(3-(3,5-dichlorophenyl)ureido)benzoic acid DMM9WB0 MI TT3PQ2Y DMM9WB0 MN Plasmodium Dihydroorotate dehydrogenase (Malaria DHOdehase) DMM9WB0 MT DTT DMM9WB0 MA Inhibitor DMM9WB0 RN Discovery of novel inhibitors for DHODH via virtual screening and X-ray crystallographic structures. Bioorg Med Chem Lett. 2010 Mar 15;20(6):1981-4. DMM9WB0 RU https://pubmed.ncbi.nlm.nih.gov/20153645 DMRX4HM DI DMRX4HM DMRX4HM DN 2-(3-(3-bromophenyl)ureido)-4-chlorobenzoic acid DMRX4HM MI TT0MYE2 DMRX4HM MN Glutamate receptor ionotropic kainate 1 (GRIK1) DMRX4HM MT DTT DMRX4HM MA Inhibitor DMRX4HM RN Bioisosteric modifications of 2-arylureidobenzoic acids: selective noncompetitive antagonists for the homomeric kainate receptor subtype GluR5. J Med Chem. 2004 Dec 30;47(27):6948-57. DMRX4HM RU https://pubmed.ncbi.nlm.nih.gov/15615543 DM1VSOK DI DM1VSOK DM1VSOK DN 2-(3-(3-methoxyphenoxy)prop-1-ynyl)pyridine DM1VSOK MI TTHS256 DM1VSOK MN Metabotropic glutamate receptor 5 (mGluR5) DM1VSOK MT DTT DM1VSOK MA Inhibitor DM1VSOK RN A new series of pyridinyl-alkynes as antagonists of the metabotropic glutamate receptor 5 (mGluR5). Bioorg Med Chem Lett. 2006 Sep 15;16(18):4792-5. DM1VSOK RU https://pubmed.ncbi.nlm.nih.gov/16839764 DMXRHOY DI DMXRHOY DMXRHOY DN 2-(3''-(4''-bromo-indolyl)ethyloxy)adenosine DMXRHOY MI TTK25J1 DMXRHOY MN Adenosine A1 receptor (ADORA1) DMXRHOY MT DTT DMXRHOY MA Inhibitor DMXRHOY RN Structure-activity relationships of 2,N(6),5'-substituted adenosine derivatives with potent activity at the A2B adenosine receptor. J Med Chem. 2007 Apr 19;50(8):1810-27. DMXRHOY RU https://pubmed.ncbi.nlm.nih.gov/17378544 DMXRHOY DI DMXRHOY DMXRHOY DN 2-(3''-(4''-bromo-indolyl)ethyloxy)adenosine DMXRHOY MI TTM2AOE DMXRHOY MN Adenosine A2a receptor (ADORA2A) DMXRHOY MT DTT DMXRHOY MA Inhibitor DMXRHOY RN Structure-activity relationships of 2,N(6),5'-substituted adenosine derivatives with potent activity at the A2B adenosine receptor. J Med Chem. 2007 Apr 19;50(8):1810-27. DMXRHOY RU https://pubmed.ncbi.nlm.nih.gov/17378544 DMXRHOY DI DMXRHOY DMXRHOY DN 2-(3''-(4''-bromo-indolyl)ethyloxy)adenosine DMXRHOY MI TTJFY5U DMXRHOY MN Adenosine A3 receptor (ADORA3) DMXRHOY MT DTT DMXRHOY MA Inhibitor DMXRHOY RN Structure-activity relationships of 2,N(6),5'-substituted adenosine derivatives with potent activity at the A2B adenosine receptor. J Med Chem. 2007 Apr 19;50(8):1810-27. DMXRHOY RU https://pubmed.ncbi.nlm.nih.gov/17378544 DMR8PGZ DI DMR8PGZ DMR8PGZ DN 2-(3''-(5''-bromo-indolyl)ethyloxy)adenosine DMR8PGZ MI TTK25J1 DMR8PGZ MN Adenosine A1 receptor (ADORA1) DMR8PGZ MT DTT DMR8PGZ MA Inhibitor DMR8PGZ RN Structure-activity relationships of 2,N(6),5'-substituted adenosine derivatives with potent activity at the A2B adenosine receptor. J Med Chem. 2007 Apr 19;50(8):1810-27. DMR8PGZ RU https://pubmed.ncbi.nlm.nih.gov/17378544 DMR8PGZ DI DMR8PGZ DMR8PGZ DN 2-(3''-(5''-bromo-indolyl)ethyloxy)adenosine DMR8PGZ MI TTM2AOE DMR8PGZ MN Adenosine A2a receptor (ADORA2A) DMR8PGZ MT DTT DMR8PGZ MA Inhibitor DMR8PGZ RN Structure-activity relationships of 2,N(6),5'-substituted adenosine derivatives with potent activity at the A2B adenosine receptor. J Med Chem. 2007 Apr 19;50(8):1810-27. DMR8PGZ RU https://pubmed.ncbi.nlm.nih.gov/17378544 DMR8PGZ DI DMR8PGZ DMR8PGZ DN 2-(3''-(5''-bromo-indolyl)ethyloxy)adenosine DMR8PGZ MI TTJFY5U DMR8PGZ MN Adenosine A3 receptor (ADORA3) DMR8PGZ MT DTT DMR8PGZ MA Inhibitor DMR8PGZ RN Structure-activity relationships of 2,N(6),5'-substituted adenosine derivatives with potent activity at the A2B adenosine receptor. J Med Chem. 2007 Apr 19;50(8):1810-27. DMR8PGZ RU https://pubmed.ncbi.nlm.nih.gov/17378544 DMD8Q3E DI DMD8Q3E DMD8Q3E DN 2-(3''(5''-chloro-indolyl)ethyloxy)adenosine DMD8Q3E MI TTK25J1 DMD8Q3E MN Adenosine A1 receptor (ADORA1) DMD8Q3E MT DTT DMD8Q3E MA Inhibitor DMD8Q3E RN Structure-activity relationships of 2,N(6),5'-substituted adenosine derivatives with potent activity at the A2B adenosine receptor. J Med Chem. 2007 Apr 19;50(8):1810-27. DMD8Q3E RU https://pubmed.ncbi.nlm.nih.gov/17378544 DMD8Q3E DI DMD8Q3E DMD8Q3E DN 2-(3''(5''-chloro-indolyl)ethyloxy)adenosine DMD8Q3E MI TTM2AOE DMD8Q3E MN Adenosine A2a receptor (ADORA2A) DMD8Q3E MT DTT DMD8Q3E MA Inhibitor DMD8Q3E RN Structure-activity relationships of 2,N(6),5'-substituted adenosine derivatives with potent activity at the A2B adenosine receptor. J Med Chem. 2007 Apr 19;50(8):1810-27. DMD8Q3E RU https://pubmed.ncbi.nlm.nih.gov/17378544 DMD8Q3E DI DMD8Q3E DMD8Q3E DN 2-(3''(5''-chloro-indolyl)ethyloxy)adenosine DMD8Q3E MI TTJFY5U DMD8Q3E MN Adenosine A3 receptor (ADORA3) DMD8Q3E MT DTT DMD8Q3E MA Inhibitor DMD8Q3E RN Structure-activity relationships of 2,N(6),5'-substituted adenosine derivatives with potent activity at the A2B adenosine receptor. J Med Chem. 2007 Apr 19;50(8):1810-27. DMD8Q3E RU https://pubmed.ncbi.nlm.nih.gov/17378544 DME3IN1 DI DME3IN1 DME3IN1 DN 2-(3''-(5''-fluoro-indolyl)ethyloxy)adenosine DME3IN1 MI TTK25J1 DME3IN1 MN Adenosine A1 receptor (ADORA1) DME3IN1 MT DTT DME3IN1 MA Inhibitor DME3IN1 RN Structure-activity relationships of 2,N(6),5'-substituted adenosine derivatives with potent activity at the A2B adenosine receptor. J Med Chem. 2007 Apr 19;50(8):1810-27. DME3IN1 RU https://pubmed.ncbi.nlm.nih.gov/17378544 DME3IN1 DI DME3IN1 DME3IN1 DN 2-(3''-(5''-fluoro-indolyl)ethyloxy)adenosine DME3IN1 MI TTM2AOE DME3IN1 MN Adenosine A2a receptor (ADORA2A) DME3IN1 MT DTT DME3IN1 MA Inhibitor DME3IN1 RN Structure-activity relationships of 2,N(6),5'-substituted adenosine derivatives with potent activity at the A2B adenosine receptor. J Med Chem. 2007 Apr 19;50(8):1810-27. DME3IN1 RU https://pubmed.ncbi.nlm.nih.gov/17378544 DME3IN1 DI DME3IN1 DME3IN1 DN 2-(3''-(5''-fluoro-indolyl)ethyloxy)adenosine DME3IN1 MI TTJFY5U DME3IN1 MN Adenosine A3 receptor (ADORA3) DME3IN1 MT DTT DME3IN1 MA Inhibitor DME3IN1 RN Structure-activity relationships of 2,N(6),5'-substituted adenosine derivatives with potent activity at the A2B adenosine receptor. J Med Chem. 2007 Apr 19;50(8):1810-27. DME3IN1 RU https://pubmed.ncbi.nlm.nih.gov/17378544 DM6BIOP DI DM6BIOP DM6BIOP DN 2-(3''-(5''-hydroxyindolyl)ethyloxy)adenosine DM6BIOP MI TTK25J1 DM6BIOP MN Adenosine A1 receptor (ADORA1) DM6BIOP MT DTT DM6BIOP MA Inhibitor DM6BIOP RN Structure-activity relationships of 2,N(6),5'-substituted adenosine derivatives with potent activity at the A2B adenosine receptor. J Med Chem. 2007 Apr 19;50(8):1810-27. DM6BIOP RU https://pubmed.ncbi.nlm.nih.gov/17378544 DM6BIOP DI DM6BIOP DM6BIOP DN 2-(3''-(5''-hydroxyindolyl)ethyloxy)adenosine DM6BIOP MI TTM2AOE DM6BIOP MN Adenosine A2a receptor (ADORA2A) DM6BIOP MT DTT DM6BIOP MA Inhibitor DM6BIOP RN Structure-activity relationships of 2,N(6),5'-substituted adenosine derivatives with potent activity at the A2B adenosine receptor. J Med Chem. 2007 Apr 19;50(8):1810-27. DM6BIOP RU https://pubmed.ncbi.nlm.nih.gov/17378544 DM6BIOP DI DM6BIOP DM6BIOP DN 2-(3''-(5''-hydroxyindolyl)ethyloxy)adenosine DM6BIOP MI TTJFY5U DM6BIOP MN Adenosine A3 receptor (ADORA3) DM6BIOP MT DTT DM6BIOP MA Inhibitor DM6BIOP RN Structure-activity relationships of 2,N(6),5'-substituted adenosine derivatives with potent activity at the A2B adenosine receptor. J Med Chem. 2007 Apr 19;50(8):1810-27. DM6BIOP RU https://pubmed.ncbi.nlm.nih.gov/17378544 DMFP0IW DI DMFP0IW DMFP0IW DN 2-(3''-(5''-iodo-indolyl)ethyloxy)adenosine DMFP0IW MI TTK25J1 DMFP0IW MN Adenosine A1 receptor (ADORA1) DMFP0IW MT DTT DMFP0IW MA Inhibitor DMFP0IW RN Structure-activity relationships of 2,N(6),5'-substituted adenosine derivatives with potent activity at the A2B adenosine receptor. J Med Chem. 2007 Apr 19;50(8):1810-27. DMFP0IW RU https://pubmed.ncbi.nlm.nih.gov/17378544 DMFP0IW DI DMFP0IW DMFP0IW DN 2-(3''-(5''-iodo-indolyl)ethyloxy)adenosine DMFP0IW MI TTM2AOE DMFP0IW MN Adenosine A2a receptor (ADORA2A) DMFP0IW MT DTT DMFP0IW MA Inhibitor DMFP0IW RN Structure-activity relationships of 2,N(6),5'-substituted adenosine derivatives with potent activity at the A2B adenosine receptor. J Med Chem. 2007 Apr 19;50(8):1810-27. DMFP0IW RU https://pubmed.ncbi.nlm.nih.gov/17378544 DMFP0IW DI DMFP0IW DMFP0IW DN 2-(3''-(5''-iodo-indolyl)ethyloxy)adenosine DMFP0IW MI TTJFY5U DMFP0IW MN Adenosine A3 receptor (ADORA3) DMFP0IW MT DTT DMFP0IW MA Inhibitor DMFP0IW RN Structure-activity relationships of 2,N(6),5'-substituted adenosine derivatives with potent activity at the A2B adenosine receptor. J Med Chem. 2007 Apr 19;50(8):1810-27. DMFP0IW RU https://pubmed.ncbi.nlm.nih.gov/17378544 DMWA0MN DI DMWA0MN DMWA0MN DN 2-(3''-(5''-methoxy-indolyl)ethyloxy)adenosine DMWA0MN MI TTK25J1 DMWA0MN MN Adenosine A1 receptor (ADORA1) DMWA0MN MT DTT DMWA0MN MA Inhibitor DMWA0MN RN Structure-activity relationships of 2,N(6),5'-substituted adenosine derivatives with potent activity at the A2B adenosine receptor. J Med Chem. 2007 Apr 19;50(8):1810-27. DMWA0MN RU https://pubmed.ncbi.nlm.nih.gov/17378544 DMWA0MN DI DMWA0MN DMWA0MN DN 2-(3''-(5''-methoxy-indolyl)ethyloxy)adenosine DMWA0MN MI TTM2AOE DMWA0MN MN Adenosine A2a receptor (ADORA2A) DMWA0MN MT DTT DMWA0MN MA Inhibitor DMWA0MN RN Structure-activity relationships of 2,N(6),5'-substituted adenosine derivatives with potent activity at the A2B adenosine receptor. J Med Chem. 2007 Apr 19;50(8):1810-27. DMWA0MN RU https://pubmed.ncbi.nlm.nih.gov/17378544 DMWA0MN DI DMWA0MN DMWA0MN DN 2-(3''-(5''-methoxy-indolyl)ethyloxy)adenosine DMWA0MN MI TTJFY5U DMWA0MN MN Adenosine A3 receptor (ADORA3) DMWA0MN MT DTT DMWA0MN MA Inhibitor DMWA0MN RN Structure-activity relationships of 2,N(6),5'-substituted adenosine derivatives with potent activity at the A2B adenosine receptor. J Med Chem. 2007 Apr 19;50(8):1810-27. DMWA0MN RU https://pubmed.ncbi.nlm.nih.gov/17378544 DMGRC24 DI DMGRC24 DMGRC24 DN 2-(3''-(6''-bromo-indolyl)ethyloxy)adenosine DMGRC24 MI TTK25J1 DMGRC24 MN Adenosine A1 receptor (ADORA1) DMGRC24 MT DTT DMGRC24 MA Inhibitor DMGRC24 RN Structure-activity relationships of 2,N(6),5'-substituted adenosine derivatives with potent activity at the A2B adenosine receptor. J Med Chem. 2007 Apr 19;50(8):1810-27. DMGRC24 RU https://pubmed.ncbi.nlm.nih.gov/17378544 DMGRC24 DI DMGRC24 DMGRC24 DN 2-(3''-(6''-bromo-indolyl)ethyloxy)adenosine DMGRC24 MI TTM2AOE DMGRC24 MN Adenosine A2a receptor (ADORA2A) DMGRC24 MT DTT DMGRC24 MA Inhibitor DMGRC24 RN Structure-activity relationships of 2,N(6),5'-substituted adenosine derivatives with potent activity at the A2B adenosine receptor. J Med Chem. 2007 Apr 19;50(8):1810-27. DMGRC24 RU https://pubmed.ncbi.nlm.nih.gov/17378544 DMGRC24 DI DMGRC24 DMGRC24 DN 2-(3''-(6''-bromo-indolyl)ethyloxy)adenosine DMGRC24 MI TTJFY5U DMGRC24 MN Adenosine A3 receptor (ADORA3) DMGRC24 MT DTT DMGRC24 MA Inhibitor DMGRC24 RN Structure-activity relationships of 2,N(6),5'-substituted adenosine derivatives with potent activity at the A2B adenosine receptor. J Med Chem. 2007 Apr 19;50(8):1810-27. DMGRC24 RU https://pubmed.ncbi.nlm.nih.gov/17378544 DML39UW DI DML39UW DML39UW DN 2-(3''-(6''-chloro-indolyl)ethyloxy)adenosine DML39UW MI TTK25J1 DML39UW MN Adenosine A1 receptor (ADORA1) DML39UW MT DTT DML39UW MA Inhibitor DML39UW RN Structure-activity relationships of 2,N(6),5'-substituted adenosine derivatives with potent activity at the A2B adenosine receptor. J Med Chem. 2007 Apr 19;50(8):1810-27. DML39UW RU https://pubmed.ncbi.nlm.nih.gov/17378544 DML39UW DI DML39UW DML39UW DN 2-(3''-(6''-chloro-indolyl)ethyloxy)adenosine DML39UW MI TTM2AOE DML39UW MN Adenosine A2a receptor (ADORA2A) DML39UW MT DTT DML39UW MA Inhibitor DML39UW RN Structure-activity relationships of 2,N(6),5'-substituted adenosine derivatives with potent activity at the A2B adenosine receptor. J Med Chem. 2007 Apr 19;50(8):1810-27. DML39UW RU https://pubmed.ncbi.nlm.nih.gov/17378544 DML39UW DI DML39UW DML39UW DN 2-(3''-(6''-chloro-indolyl)ethyloxy)adenosine DML39UW MI TTJFY5U DML39UW MN Adenosine A3 receptor (ADORA3) DML39UW MT DTT DML39UW MA Inhibitor DML39UW RN Structure-activity relationships of 2,N(6),5'-substituted adenosine derivatives with potent activity at the A2B adenosine receptor. J Med Chem. 2007 Apr 19;50(8):1810-27. DML39UW RU https://pubmed.ncbi.nlm.nih.gov/17378544 DMITEND DI DMITEND DMITEND DN 2-(3''(7''-bromo-indolyl)ethyloxy)adenosine DMITEND MI TTK25J1 DMITEND MN Adenosine A1 receptor (ADORA1) DMITEND MT DTT DMITEND MA Inhibitor DMITEND RN Structure-activity relationships of 2,N(6),5'-substituted adenosine derivatives with potent activity at the A2B adenosine receptor. J Med Chem. 2007 Apr 19;50(8):1810-27. DMITEND RU https://pubmed.ncbi.nlm.nih.gov/17378544 DMITEND DI DMITEND DMITEND DN 2-(3''(7''-bromo-indolyl)ethyloxy)adenosine DMITEND MI TTM2AOE DMITEND MN Adenosine A2a receptor (ADORA2A) DMITEND MT DTT DMITEND MA Inhibitor DMITEND RN Structure-activity relationships of 2,N(6),5'-substituted adenosine derivatives with potent activity at the A2B adenosine receptor. J Med Chem. 2007 Apr 19;50(8):1810-27. DMITEND RU https://pubmed.ncbi.nlm.nih.gov/17378544 DMITEND DI DMITEND DMITEND DN 2-(3''(7''-bromo-indolyl)ethyloxy)adenosine DMITEND MI TTJFY5U DMITEND MN Adenosine A3 receptor (ADORA3) DMITEND MT DTT DMITEND MA Inhibitor DMITEND RN Structure-activity relationships of 2,N(6),5'-substituted adenosine derivatives with potent activity at the A2B adenosine receptor. J Med Chem. 2007 Apr 19;50(8):1810-27. DMITEND RU https://pubmed.ncbi.nlm.nih.gov/17378544 DMLDOH6 DI DMLDOH6 DMLDOH6 DN 2-(3''-(benzoimidazole-1''-yl)ethyloxy)adenosine DMLDOH6 MI TTM2AOE DMLDOH6 MN Adenosine A2a receptor (ADORA2A) DMLDOH6 MT DTT DMLDOH6 MA Inhibitor DMLDOH6 RN Structure-activity relationships of 2,N(6),5'-substituted adenosine derivatives with potent activity at the A2B adenosine receptor. J Med Chem. 2007 Apr 19;50(8):1810-27. DMLDOH6 RU https://pubmed.ncbi.nlm.nih.gov/17378544 DMLDOH6 DI DMLDOH6 DMLDOH6 DN 2-(3''-(benzoimidazole-1''-yl)ethyloxy)adenosine DMLDOH6 MI TTJFY5U DMLDOH6 MN Adenosine A3 receptor (ADORA3) DMLDOH6 MT DTT DMLDOH6 MA Inhibitor DMLDOH6 RN Structure-activity relationships of 2,N(6),5'-substituted adenosine derivatives with potent activity at the A2B adenosine receptor. J Med Chem. 2007 Apr 19;50(8):1810-27. DMLDOH6 RU https://pubmed.ncbi.nlm.nih.gov/17378544 DM1KCUV DI DM1KCUV DM1KCUV DN 2-(3''-(benzotriazole-1''-yl)ethyloxy)adenosine DM1KCUV MI TTJFY5U DM1KCUV MN Adenosine A3 receptor (ADORA3) DM1KCUV MT DTT DM1KCUV MA Inhibitor DM1KCUV RN Structure-activity relationships of 2,N(6),5'-substituted adenosine derivatives with potent activity at the A2B adenosine receptor. J Med Chem. 2007 Apr 19;50(8):1810-27. DM1KCUV RU https://pubmed.ncbi.nlm.nih.gov/17378544 DM0R5U6 DI DM0R5U6 DM0R5U6 DN 2-(3-(benzyloxy)phenyl)isoindoline-1,3-dione DM0R5U6 MI TTHS256 DM0R5U6 MN Metabotropic glutamate receptor 5 (mGluR5) DM0R5U6 MT DTT DM0R5U6 MA Inhibitor DM0R5U6 RN Arylmethoxypyridines as novel, potent and orally active mGlu5 receptor antagonists. Bioorg Med Chem Lett. 2006 Apr 1;16(7):1892-7. DM0R5U6 RU https://pubmed.ncbi.nlm.nih.gov/16439120 DMKEY9V DI DMKEY9V DMKEY9V DN 2-(3-(naphthalen-2-yl)propanamido)benzoic acid DMKEY9V MI TTWNV8U DMKEY9V MN Nicotinic acid receptor (HCAR2) DMKEY9V MT DTT DMKEY9V MA Inhibitor DMKEY9V RN Molecular modeling aided design of nicotinic acid receptor GPR109A agonists. Bioorg Med Chem Lett. 2008 Sep 15;18(18):4963-7. DMKEY9V RU https://pubmed.ncbi.nlm.nih.gov/18760600 DM94B7N DI DM94B7N DM94B7N DN 2-(3-(phenylsulfonyl)-1H-indol-1-yl)ethanamine DM94B7N MI TTJS8PY DM94B7N MN 5-HT 6 receptor (HTR6) DM94B7N MT DTT DM94B7N MA Inhibitor DM94B7N RN Novel 1-aminoethyl-3-arylsulfonyl-1H-pyrrolo[2,3-b]pyridines are potent 5-HT(6) agonists. Bioorg Med Chem. 2009 Jul 15;17(14):5153-63. DM94B7N RU https://pubmed.ncbi.nlm.nih.gov/19523834 DM1I6SO DI DM1I6SO DM1I6SO DN 2-(3,4,5-Trihydroxy-benzylidene)-malononitrile DM1I6SO MI TT860QF DM1I6SO MN LCK tyrosine protein kinase (LCK) DM1I6SO MT DTT DM1I6SO MA Inhibitor DM1I6SO RN Tyrphostins. 3. Structure-activity relationship studies of alpha-substituted benzylidenemalononitrile 5-S-aryltyrphostins. J Med Chem. 1993 Nov 12;36(23):3556-64. DM1I6SO RU https://pubmed.ncbi.nlm.nih.gov/7902440 DMJKVZ3 DI DMJKVZ3 DMJKVZ3 DN 2-(3,4-Difluorophenyl)-2,2-diphenylacetamide DMJKVZ3 MI TTMNI76 DMJKVZ3 MN Calcium-activated potassium channel (KCN) DMJKVZ3 MT DTT DMJKVZ3 MA Inhibitor DMJKVZ3 RN Novel inhibitors of the Gardos channel for the treatment of sickle cell disease. J Med Chem. 2008 Feb 28;51(4):976-82. DMJKVZ3 RU https://pubmed.ncbi.nlm.nih.gov/18232633 DMAOD0K DI DMAOD0K DMAOD0K DN 2-(3,4-Dihydroxy-benzyl)-7-hydroxy-chromen-4-one DMAOD0K MI TTFBNVI DMAOD0K MN Aldose reductase (AKR1B1) DMAOD0K MT DTT DMAOD0K MA Inhibitor DMAOD0K RN 1-Benzopyran-4-one antioxidants as aldose reductase inhibitors. J Med Chem. 1999 Jun 3;42(11):1881-93. DMAOD0K RU https://pubmed.ncbi.nlm.nih.gov/10354396 DM5MKEI DI DM5MKEI DM5MKEI DN 2-(3,4-Dihydroxy-phenyl)-7-hydroxy-chromen-4-one DM5MKEI MI TTFBNVI DM5MKEI MN Aldose reductase (AKR1B1) DM5MKEI MT DTT DM5MKEI MA Inhibitor DM5MKEI RN 1-Benzopyran-4-one antioxidants as aldose reductase inhibitors. J Med Chem. 1999 Jun 3;42(11):1881-93. DM5MKEI RU https://pubmed.ncbi.nlm.nih.gov/10354396 DMSZ0H9 DI DMSZ0H9 DMSZ0H9 DN 2-(3,4-Dihydroxyphenyl)Acetic Acid DMSZ0H9 MI TTUTN1I DMSZ0H9 MN Human Deoxyribonucleic acid (hDNA) DMSZ0H9 MT DTT DMSZ0H9 MA Inhibitor DMSZ0H9 RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMSZ0H9 RU https://pubmed.ncbi.nlm.nih.gov/17139284 DM3S26I DI DM3S26I DM3S26I DN 2-(3,4-dimethoxybenzamido)thiophene-3-carboxamide DM3S26I MI TTGJCWZ DM3S26I MN Fms-like tyrosine kinase 3 (FLT-3) DM3S26I MT DTT DM3S26I MA Inhibitor DM3S26I RN Identification of 2-acylaminothiophene-3-carboxamides as potent inhibitors of FLT3. Bioorg Med Chem Lett. 2006 Jun 15;16(12):3282-6. DM3S26I RU https://pubmed.ncbi.nlm.nih.gov/16580199 DMLOX0Y DI DMLOX0Y DMLOX0Y DN 2-(3,4-dimethoxyphenyl)-4,5-dihydro-1H-imidazole DMLOX0Y MI TT3WG5C DMLOX0Y MN Monoamine oxidase type A (MAO-A) DMLOX0Y MT DTT DMLOX0Y MA Inhibitor DMLOX0Y RN Ultrasound promoted synthesis of 2-imidazolines in water: a greener approach toward monoamine oxidase inhibitors. Bioorg Med Chem Lett. 2009 Jan 15;19(2):546-9. DMLOX0Y RU https://pubmed.ncbi.nlm.nih.gov/19064321 DMDGRWM DI DMDGRWM DMDGRWM DN 2-(3,4-dimethylphenyl)-1,8-naphthyridine DMDGRWM MI TTHS256 DMDGRWM MN Metabotropic glutamate receptor 5 (mGluR5) DMDGRWM MT DTT DMDGRWM MA Inhibitor DMDGRWM RN Synthesis and SAR comparison of regioisomeric aryl naphthyridines as potent mGlu5 receptor antagonists. Bioorg Med Chem Lett. 2007 Dec 1;17(23):6525-8. DMDGRWM RU https://pubmed.ncbi.nlm.nih.gov/17936624 DM8KM1Q DI DM8KM1Q DM8KM1Q DN 2-(3,5-dichlorophenyl)pyrido[2,3-d]pyrimidine DM8KM1Q MI TTHS256 DM8KM1Q MN Metabotropic glutamate receptor 5 (mGluR5) DM8KM1Q MT DTT DM8KM1Q MA Inhibitor DM8KM1Q RN Synthesis and SAR of 2-aryl pyrido[2,3-d]pyrimidines as potent mGlu5 receptor antagonists. Bioorg Med Chem Lett. 2007 Oct 1;17(19):5396-9. DM8KM1Q RU https://pubmed.ncbi.nlm.nih.gov/17723296 DMGJPYO DI DMGJPYO DMGJPYO DN 2-(3,5-difluorophenyl)-7-methyl-1,8-naphthyridine DMGJPYO MI TTHS256 DMGJPYO MN Metabotropic glutamate receptor 5 (mGluR5) DMGJPYO MT DTT DMGJPYO MA Inhibitor DMGJPYO RN Synthesis and SAR comparison of regioisomeric aryl naphthyridines as potent mGlu5 receptor antagonists. Bioorg Med Chem Lett. 2007 Dec 1;17(23):6525-8. DMGJPYO RU https://pubmed.ncbi.nlm.nih.gov/17936624 DMIEB8R DI DMIEB8R DMIEB8R DN 2-(3,5-dimethoxy-4-phenethoxyphenyl)ethanamine DMIEB8R MI TTJQOD7 DMIEB8R MN 5-HT 2A receptor (HTR2A) DMIEB8R MT DTT DMIEB8R MA Inhibitor DMIEB8R RN The role of lipophilicity in determining binding affinity and functional activity for 5-HT2A receptor ligands. Bioorg Med Chem. 2008 Apr 15;16(8):4661-9. DMIEB8R RU https://pubmed.ncbi.nlm.nih.gov/18296055 DMKND0T DI DMKND0T DMKND0T DN 2-(3,5-dimethoxyphenyl)-1,8-naphthyridine DMKND0T MI TTHS256 DMKND0T MN Metabotropic glutamate receptor 5 (mGluR5) DMKND0T MT DTT DMKND0T MA Inhibitor DMKND0T RN Synthesis and SAR comparison of regioisomeric aryl naphthyridines as potent mGlu5 receptor antagonists. Bioorg Med Chem Lett. 2007 Dec 1;17(23):6525-8. DMKND0T RU https://pubmed.ncbi.nlm.nih.gov/17936624 DMJ2NPY DI DMJ2NPY DMJ2NPY DN 2-(3-acetylphenyl)-6-morpholino-4H-pyran-4-one DMJ2NPY MI TTK3PY9 DMJ2NPY MN DNA-dependent protein kinase catalytic (PRKDC) DMJ2NPY MT DTT DMJ2NPY MA Inhibitor DMJ2NPY RN Pyranone, thiopyranone, and pyridone inhibitors of phosphatidylinositol 3-kinase related kinases. Structure-activity relationships for DNA-dependen... J Med Chem. 2007 Apr 19;50(8):1958-72. DMJ2NPY RU https://pubmed.ncbi.nlm.nih.gov/17371003 DMAGFUH DI DMAGFUH DMAGFUH DN 2-(3'-Allyl-biphenyl-4-yl)-propionic acid DMAGFUH MI TT8NGED DMAGFUH MN Prostaglandin G/H synthase 1 (COX-1) DMAGFUH MT DTT DMAGFUH MA Inhibitor DMAGFUH RN Structure-based design of COX-2 selectivity into flurbiprofen. Bioorg Med Chem Lett. 1999 Feb 8;9(3):307-12. DMAGFUH RU https://pubmed.ncbi.nlm.nih.gov/10091674 DMC6E8R DI DMC6E8R DMC6E8R DN 2-(3-aminophenoxy)-5-hexylphenol DMC6E8R MI TTVTX4N DMC6E8R MN Bacterial Fatty acid synthetase I (Bact inhA) DMC6E8R MT DTT DMC6E8R MA Inhibitor DMC6E8R RN Synthesis and in vitro antimycobacterial activity of B-ring modified diaryl ether InhA inhibitors. Bioorg Med Chem Lett. 2008 May 15;18(10):3029-33. DMC6E8R RU https://pubmed.ncbi.nlm.nih.gov/18457948 DMQB9SC DI DMQB9SC DMQB9SC DN 2-(3-aminophenyl)-3-mercaptopropanoic acid DMQB9SC MI TTP18AY DMQB9SC MN Carboxypeptidase B2 (CPB2) DMQB9SC MT DTT DMQB9SC MA Inhibitor DMQB9SC RN 3-Mercaptopropionic acids as efficacious inhibitors of activated thrombin activatable fibrinolysis inhibitor (TAFIa). Bioorg Med Chem Lett. 2007 Mar 1;17(5):1349-54. DMQB9SC RU https://pubmed.ncbi.nlm.nih.gov/17189688 DMAP37I DI DMAP37I DMAP37I DN 2-(3-Amino-phenyl)-6-methyl-chromen-4-one DMAP37I MI TTNJYV2 DMAP37I MN Gamma-aminobutyric acid receptor (GAR) DMAP37I MT DTT DMAP37I MA Inhibitor DMAP37I RN Refinement and evaluation of a pharmacophore model for flavone derivatives binding to the benzodiazepine site of the GABA(A) receptor. J Med Chem. 2002 Sep 12;45(19):4188-201. DMAP37I RU https://pubmed.ncbi.nlm.nih.gov/12213060 DM3FBLT DI DM3FBLT DM3FBLT DN 2-(3-benzenesulfonyl)phenyl-1-aminoethane DM3FBLT MI TTJS8PY DM3FBLT MN 5-HT 6 receptor (HTR6) DM3FBLT MT DTT DM3FBLT MA Inhibitor DM3FBLT RN Binding of sulfonyl-containing arylalkylamines at human 5-HT6 serotonin receptors. J Med Chem. 2006 Aug 24;49(17):5217-25. DM3FBLT RU https://pubmed.ncbi.nlm.nih.gov/16913710 DMDB4LZ DI DMDB4LZ DMDB4LZ DN 2-(3-benzoyl-1H-pyrrol-1-yl)acetic acid DMDB4LZ MI TTFBNVI DMDB4LZ MN Aldose reductase (AKR1B1) DMDB4LZ MT DTT DMDB4LZ MA Inhibitor DMDB4LZ RN Design and synthesis of novel series of pyrrole based chemotypes and their evaluation as selective aldose reductase inhibitors. A case of bioisoste... Bioorg Med Chem. 2010 Mar 15;18(6):2107-2114. DMDB4LZ RU https://pubmed.ncbi.nlm.nih.gov/20189816 DMWMFTJ DI DMWMFTJ DMWMFTJ DN 2-(3-BENZOYLPHENOXY)ETHYL(HYDROXY)FORMAMIDE DMWMFTJ MI TTICO5G DMWMFTJ MN Staphylococcus Peptide deformylase (Stap-coc def) DMWMFTJ MT DTT DMWMFTJ MA Inhibitor DMWMFTJ RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DMWMFTJ RU https://pubmed.ncbi.nlm.nih.gov/10592235 DM6V91D DI DM6V91D DM6V91D DN 2-(3-benzylquinoxalin-2-ylamino)ethanol DM6V91D MI TT3WG5C DM6V91D MN Monoamine oxidase type A (MAO-A) DM6V91D MT DTT DM6V91D MA Inhibitor DM6V91D RN Synthesis of 3-benzyl-2-substituted quinoxalines as novel monoamine oxidase A inhibitors. Bioorg Med Chem Lett. 2006 Mar 15;16(6):1753-6. DM6V91D RU https://pubmed.ncbi.nlm.nih.gov/16356714 DMY60K3 DI DMY60K3 DMY60K3 DN 2-(3-biphenyl-4-yl-propionylamino)-benzoic acid DMY60K3 MI TTWNV8U DMY60K3 MN Nicotinic acid receptor (HCAR2) DMY60K3 MT DTT DMY60K3 MA Inhibitor DMY60K3 RN Discovery of biaryl anthranilides as full agonists for the high affinity niacin receptor. J Med Chem. 2007 Dec 13;50(25):6303-6. DMY60K3 RU https://pubmed.ncbi.nlm.nih.gov/17994679 DMX4DUR DI DMX4DUR DMX4DUR DN 2-(3-bromobenzoylamino)-4-chlorobenzoic acid DMX4DUR MI TT0MYE2 DMX4DUR MN Glutamate receptor ionotropic kainate 1 (GRIK1) DMX4DUR MT DTT DMX4DUR MA Inhibitor DMX4DUR RN Bioisosteric modifications of 2-arylureidobenzoic acids: selective noncompetitive antagonists for the homomeric kainate receptor subtype GluR5. J Med Chem. 2004 Dec 30;47(27):6948-57. DMX4DUR RU https://pubmed.ncbi.nlm.nih.gov/15615543 DM9G7B6 DI DM9G7B6 DM9G7B6 DN 2-(3-Bromo-phenyl)-6-methyl-chromen-4-one DM9G7B6 MI TTNJYV2 DM9G7B6 MN Gamma-aminobutyric acid receptor (GAR) DM9G7B6 MT DTT DM9G7B6 MA Inhibitor DM9G7B6 RN Refinement and evaluation of a pharmacophore model for flavone derivatives binding to the benzodiazepine site of the GABA(A) receptor. J Med Chem. 2002 Sep 12;45(19):4188-201. DM9G7B6 RU https://pubmed.ncbi.nlm.nih.gov/12213060 DM9RAYC DI DM9RAYC DM9RAYC DN 2-(3-Bromo-phenyl)-6-nitro-chromen-4-one DM9RAYC MI TT1MPAY DM9RAYC MN GABA(A) receptor alpha-1 (GABRA1) DM9RAYC MT DTT DM9RAYC MA Inhibitor DM9RAYC RN Synthesis of halogenated/nitrated flavone derivatives and evaluation of their affinity for the central benzodiazepine receptor, Bioorg. Med. Chem. Lett. 7(15):2003-2008 (1997). DM9RAYC RU http://www.sciencedirect.com/science/article/pii/S0960894X97003430 DM9RAYC DI DM9RAYC DM9RAYC DN 2-(3-Bromo-phenyl)-6-nitro-chromen-4-one DM9RAYC MI TTNJYV2 DM9RAYC MN Gamma-aminobutyric acid receptor (GAR) DM9RAYC MT DTT DM9RAYC MA Inhibitor DM9RAYC RN Synthesis of halogenated/nitrated flavone derivatives and evaluation of their affinity for the central benzodiazepine receptor, Bioorg. Med. Chem. Lett. 7(15):2003-2008 (1997). DM9RAYC RU http://www.sciencedirect.com/science/article/pii/S0960894X97003430 DMYSM9L DI DMYSM9L DMYSM9L DN 2-(3-bromophenyl)-7-methyl-1,8-naphthyridine DMYSM9L MI TTHS256 DMYSM9L MN Metabotropic glutamate receptor 5 (mGluR5) DMYSM9L MT DTT DMYSM9L MA Inhibitor DMYSM9L RN Synthesis and SAR comparison of regioisomeric aryl naphthyridines as potent mGlu5 receptor antagonists. Bioorg Med Chem Lett. 2007 Dec 1;17(23):6525-8. DMYSM9L RU https://pubmed.ncbi.nlm.nih.gov/17936624 DMANS5X DI DMANS5X DMANS5X DN 2-(3-bromophenyl)-7-methylpyrido[2,3-d]pyrimidine DMANS5X MI TTHS256 DMANS5X MN Metabotropic glutamate receptor 5 (mGluR5) DMANS5X MT DTT DMANS5X MA Inhibitor DMANS5X RN Synthesis and SAR of 2-aryl pyrido[2,3-d]pyrimidines as potent mGlu5 receptor antagonists. Bioorg Med Chem Lett. 2007 Oct 1;17(19):5396-9. DMANS5X RU https://pubmed.ncbi.nlm.nih.gov/17723296 DM7XDLO DI DM7XDLO DM7XDLO DN 2-(3-Bromo-phenyl)-chromen-4-one DM7XDLO MI TT1MPAY DM7XDLO MN GABA(A) receptor alpha-1 (GABRA1) DM7XDLO MT DTT DM7XDLO MA Inhibitor DM7XDLO RN Synthesis of halogenated/nitrated flavone derivatives and evaluation of their affinity for the central benzodiazepine receptor, Bioorg. Med. Chem. Lett. 7(15):2003-2008 (1997). DM7XDLO RU http://www.sciencedirect.com/science/article/pii/S0960894X97003430 DM7XDLO DI DM7XDLO DM7XDLO DN 2-(3-Bromo-phenyl)-chromen-4-one DM7XDLO MI TTNJYV2 DM7XDLO MN Gamma-aminobutyric acid receptor (GAR) DM7XDLO MT DTT DM7XDLO MA Inhibitor DM7XDLO RN Synthesis of halogenated/nitrated flavone derivatives and evaluation of their affinity for the central benzodiazepine receptor, Bioorg. Med. Chem. Lett. 7(15):2003-2008 (1997). DM7XDLO RU http://www.sciencedirect.com/science/article/pii/S0960894X97003430 DM260RG DI DM260RG DM260RG DN 2-(3-bromophenyl)histamine DM260RG MI TTTIBOJ DM260RG MN Histamine H1 receptor (H1R) DM260RG MT DTT DM260RG MA Agonist DM260RG RN Multiple differences in agonist and antagonist pharmacology between human and guinea pig histamine H1-receptor. J Pharmacol Exp Ther. 2003 Jun;305(3):1104-15. DM260RG RU https://pubmed.ncbi.nlm.nih.gov/12626648 DM260RG DI DM260RG DM260RG DN 2-(3-bromophenyl)histamine DM260RG MI TTXJ178 DM260RG MN Histamine H4 receptor (H4R) DM260RG MT DTT DM260RG MA Agonist DM260RG RN Evaluation of histamine H1-, H2-, and H3-receptor ligands at the human histamine H4 receptor: identification of 4-methylhistamine as the first pote... J Pharmacol Exp Ther. 2005 Sep;314(3):1310-21. DM260RG RU https://pubmed.ncbi.nlm.nih.gov/15947036 DMVA4XC DI DMVA4XC DMVA4XC DN 2-(3-bromophenyl)pyrido[2,3-d]pyrimidine DMVA4XC MI TTHS256 DMVA4XC MN Metabotropic glutamate receptor 5 (mGluR5) DMVA4XC MT DTT DMVA4XC MA Inhibitor DMVA4XC RN Synthesis and SAR of 2-aryl pyrido[2,3-d]pyrimidines as potent mGlu5 receptor antagonists. Bioorg Med Chem Lett. 2007 Oct 1;17(19):5396-9. DMVA4XC RU https://pubmed.ncbi.nlm.nih.gov/17723296 DMFETRH DI DMFETRH DMFETRH DN 2-(3-Bromophenylthio)-N,N-dimethylethanamine DMFETRH MI TTSQIFT DMFETRH MN 5-HT 1A receptor (HTR1A) DMFETRH MT DTT DMFETRH MA Inhibitor DMFETRH RN SAR studies on new bis-aryls 5-HT7 ligands: Synthesis and molecular modeling. Bioorg Med Chem. 2010 Mar 1;18(5):1958-67. DMFETRH RU https://pubmed.ncbi.nlm.nih.gov/20138771 DMJM5VW DI DMJM5VW DMJM5VW DN 2-(3-Butoxy-4-hydroxy-phenyl)-benzooxazol-6-ol DMJM5VW MI TTZAYWL DMJM5VW MN Estrogen receptor (ESR) DMJM5VW MT DTT DMJM5VW MA Inhibitor DMJM5VW RN Design and synthesis of aryl diphenolic azoles as potent and selective estrogen receptor-beta ligands. J Med Chem. 2004 Oct 7;47(21):5021-40. DMJM5VW RU https://pubmed.ncbi.nlm.nih.gov/15456246 DMJM5VW DI DMJM5VW DMJM5VW DN 2-(3-Butoxy-4-hydroxy-phenyl)-benzooxazol-6-ol DMJM5VW MI TTOM3J0 DMJM5VW MN Estrogen receptor beta (ESR2) DMJM5VW MT DTT DMJM5VW MA Inhibitor DMJM5VW RN Design and synthesis of aryl diphenolic azoles as potent and selective estrogen receptor-beta ligands. J Med Chem. 2004 Oct 7;47(21):5021-40. DMJM5VW RU https://pubmed.ncbi.nlm.nih.gov/15456246 DMSZT9G DI DMSZT9G DMSZT9G DN 2-(3-Butoxy-phenyl)-6-methyl-chromen-4-one DMSZT9G MI TTNJYV2 DMSZT9G MN Gamma-aminobutyric acid receptor (GAR) DMSZT9G MT DTT DMSZT9G MA Inhibitor DMSZT9G RN Refinement and evaluation of a pharmacophore model for flavone derivatives binding to the benzodiazepine site of the GABA(A) receptor. J Med Chem. 2002 Sep 12;45(19):4188-201. DMSZT9G RU https://pubmed.ncbi.nlm.nih.gov/12213060 DMHXVNZ DI DMHXVNZ DMHXVNZ DN 2-(3-carbamoylbenzyl)-5-mercaptopentanoic acid DMHXVNZ MI TT9G4N0 DMHXVNZ MN Glutamate carboxypeptidase II (GCPII) DMHXVNZ MT DTT DMHXVNZ MA Inhibitor DMHXVNZ RN Structural optimization of thiol-based inhibitors of glutamate carboxypeptidase II by modification of the P1' side chain. J Med Chem. 2006 May 18;49(10):2876-85. DMHXVNZ RU https://pubmed.ncbi.nlm.nih.gov/16686531 DMI6AZ5 DI DMI6AZ5 DMI6AZ5 DN 2-(3-carboxybenzyl)succinic acid DMI6AZ5 MI TT9G4N0 DMI6AZ5 MN Glutamate carboxypeptidase II (GCPII) DMI6AZ5 MT DTT DMI6AZ5 MA Inhibitor DMI6AZ5 RN Structural optimization of thiol-based inhibitors of glutamate carboxypeptidase II by modification of the P1' side chain. J Med Chem. 2006 May 18;49(10):2876-85. DMI6AZ5 RU https://pubmed.ncbi.nlm.nih.gov/16686531 DMBONUV DI DMBONUV DMBONUV DN 2-(3-Chloro-4-hydroxy-phenyl)-benzooxazol-5-ol DMBONUV MI TTZAYWL DMBONUV MN Estrogen receptor (ESR) DMBONUV MT DTT DMBONUV MA Inhibitor DMBONUV RN Design and synthesis of aryl diphenolic azoles as potent and selective estrogen receptor-beta ligands. J Med Chem. 2004 Oct 7;47(21):5021-40. DMBONUV RU https://pubmed.ncbi.nlm.nih.gov/15456246 DMBONUV DI DMBONUV DMBONUV DN 2-(3-Chloro-4-hydroxy-phenyl)-benzooxazol-5-ol DMBONUV MI TTOM3J0 DMBONUV MN Estrogen receptor beta (ESR2) DMBONUV MT DTT DMBONUV MA Inhibitor DMBONUV RN Design and synthesis of aryl diphenolic azoles as potent and selective estrogen receptor-beta ligands. J Med Chem. 2004 Oct 7;47(21):5021-40. DMBONUV RU https://pubmed.ncbi.nlm.nih.gov/15456246 DM3B6IN DI DM3B6IN DM3B6IN DN 2-(3-Chloro-4-hydroxy-phenyl)-benzooxazol-6-ol DM3B6IN MI TTZAYWL DM3B6IN MN Estrogen receptor (ESR) DM3B6IN MT DTT DM3B6IN MA Inhibitor DM3B6IN RN Design and synthesis of aryl diphenolic azoles as potent and selective estrogen receptor-beta ligands. J Med Chem. 2004 Oct 7;47(21):5021-40. DM3B6IN RU https://pubmed.ncbi.nlm.nih.gov/15456246 DM3B6IN DI DM3B6IN DM3B6IN DN 2-(3-Chloro-4-hydroxy-phenyl)-benzooxazol-6-ol DM3B6IN MI TTOM3J0 DM3B6IN MN Estrogen receptor beta (ESR2) DM3B6IN MT DTT DM3B6IN MA Inhibitor DM3B6IN RN Design and synthesis of aryl diphenolic azoles as potent and selective estrogen receptor-beta ligands. J Med Chem. 2004 Oct 7;47(21):5021-40. DM3B6IN RU https://pubmed.ncbi.nlm.nih.gov/15456246 DM1VDC3 DI DM1VDC3 DM1VDC3 DN 2-(3-chlorobenzyloxy)-6-chloroisonicotinonitrile DM1VDC3 MI TTHS256 DM1VDC3 MN Metabotropic glutamate receptor 5 (mGluR5) DM1VDC3 MT DTT DM1VDC3 MA Inhibitor DM1VDC3 RN Arylmethoxypyridines as novel, potent and orally active mGlu5 receptor antagonists. Bioorg Med Chem Lett. 2006 Apr 1;16(7):1892-7. DM1VDC3 RU https://pubmed.ncbi.nlm.nih.gov/16439120 DMK6CD9 DI DMK6CD9 DMK6CD9 DN 2-(3-Chloro-phenyl)-1H-[1,8]naphthyridin-4-one DMK6CD9 MI TTML2WA DMK6CD9 MN Tubulin (TUB) DMK6CD9 MT DTT DMK6CD9 MA Inhibitor DMK6CD9 RN Antitumor agents. 178. Synthesis and biological evaluation of substituted 2-aryl-1,8-naphthyridin-4(1H)-ones as antitumor agents that inhibit tubul... J Med Chem. 1997 Sep 12;40(19):3049-56. DMK6CD9 RU https://pubmed.ncbi.nlm.nih.gov/9301667 DMK6CD9 DI DMK6CD9 DMK6CD9 DN 2-(3-Chloro-phenyl)-1H-[1,8]naphthyridin-4-one DMK6CD9 MI TTYFKSZ DMK6CD9 MN Tubulin beta (TUBB) DMK6CD9 MT DTT DMK6CD9 MA Inhibitor DMK6CD9 RN Antitumor agents. 178. Synthesis and biological evaluation of substituted 2-aryl-1,8-naphthyridin-4(1H)-ones as antitumor agents that inhibit tubul... J Med Chem. 1997 Sep 12;40(19):3049-56. DMK6CD9 RU https://pubmed.ncbi.nlm.nih.gov/9301667 DMYQBSV DI DMYQBSV DMYQBSV DN 2-(3-Chlorophenyl)-2H-indazole-7-carboxamide DMYQBSV MI TTVDSZ0 DMYQBSV MN Poly [ADP-ribose] polymerase 1 (PARP1) DMYQBSV MT DTT DMYQBSV MA Inhibitor DMYQBSV RN Discovery of 2-{4-[(3S)-piperidin-3-yl]phenyl}-2H-indazole-7-carboxamide (MK-4827): a novel oral poly(ADP-ribose)polymerase (PARP) inhibitor effica... J Med Chem. 2009 Nov 26;52(22):7170-85. DMYQBSV RU https://pubmed.ncbi.nlm.nih.gov/19873981 DM7BC50 DI DM7BC50 DM7BC50 DN 2-(3-chlorophenyl)-7-methyl-1,8-naphthyridine DM7BC50 MI TTHS256 DM7BC50 MN Metabotropic glutamate receptor 5 (mGluR5) DM7BC50 MT DTT DM7BC50 MA Inhibitor DM7BC50 RN Synthesis and SAR comparison of regioisomeric aryl naphthyridines as potent mGlu5 receptor antagonists. Bioorg Med Chem Lett. 2007 Dec 1;17(23):6525-8. DM7BC50 RU https://pubmed.ncbi.nlm.nih.gov/17936624 DML83DM DI DML83DM DML83DM DN 2-(3-Chloro-phenyl)-chromen-4-one DML83DM MI TT1MPAY DML83DM MN GABA(A) receptor alpha-1 (GABRA1) DML83DM MT DTT DML83DM MA Inhibitor DML83DM RN Synthesis of halogenated/nitrated flavone derivatives and evaluation of their affinity for the central benzodiazepine receptor, Bioorg. Med. Chem. Lett. 7(15):2003-2008 (1997). DML83DM RU http://www.sciencedirect.com/science/article/pii/S0960894X97003430 DML83DM DI DML83DM DML83DM DN 2-(3-Chloro-phenyl)-chromen-4-one DML83DM MI TTNJYV2 DML83DM MN Gamma-aminobutyric acid receptor (GAR) DML83DM MT DTT DML83DM MA Inhibitor DML83DM RN Synthesis of halogenated/nitrated flavone derivatives and evaluation of their affinity for the central benzodiazepine receptor, Bioorg. Med. Chem. Lett. 7(15):2003-2008 (1997). DML83DM RU http://www.sciencedirect.com/science/article/pii/S0960894X97003430 DMO0Y79 DI DMO0Y79 DMO0Y79 DN 2-(3-chlorophenyl)histamine DMO0Y79 MI TTTIBOJ DMO0Y79 MN Histamine H1 receptor (H1R) DMO0Y79 MT DTT DMO0Y79 MA Agonist DMO0Y79 RN Multiple differences in agonist and antagonist pharmacology between human and guinea pig histamine H1-receptor. J Pharmacol Exp Ther. 2003 Jun;305(3):1104-15. DMO0Y79 RU https://pubmed.ncbi.nlm.nih.gov/12626648 DMVB5U0 DI DMVB5U0 DMVB5U0 DN 2-(3-cyanobenzyl)-5-mercaptopentanoic acid DMVB5U0 MI TT9G4N0 DMVB5U0 MN Glutamate carboxypeptidase II (GCPII) DMVB5U0 MT DTT DMVB5U0 MA Inhibitor DMVB5U0 RN Structural optimization of thiol-based inhibitors of glutamate carboxypeptidase II by modification of the P1' side chain. J Med Chem. 2006 May 18;49(10):2876-85. DMVB5U0 RU https://pubmed.ncbi.nlm.nih.gov/16686531 DMPLN58 DI DMPLN58 DMPLN58 DN 2-(3'-Ethyl-biphenyl-4-yl)-propionic acid DMPLN58 MI TT8NGED DMPLN58 MN Prostaglandin G/H synthase 1 (COX-1) DMPLN58 MT DTT DMPLN58 MA Inhibitor DMPLN58 RN Structure-based design of COX-2 selectivity into flurbiprofen. Bioorg Med Chem Lett. 1999 Feb 8;9(3):307-12. DMPLN58 RU https://pubmed.ncbi.nlm.nih.gov/10091674 DMPGYDA DI DMPGYDA DMPGYDA DN 2-(3'-Ethylsulfanyl-biphenyl-4-yl)-propionic acid DMPGYDA MI TT8NGED DMPGYDA MN Prostaglandin G/H synthase 1 (COX-1) DMPGYDA MT DTT DMPGYDA MA Inhibitor DMPGYDA RN Structure-based design of COX-2 selectivity into flurbiprofen. Bioorg Med Chem Lett. 1999 Feb 8;9(3):307-12. DMPGYDA RU https://pubmed.ncbi.nlm.nih.gov/10091674 DMNTHK5 DI DMNTHK5 DMNTHK5 DN 2-(3-Fluoro-4-hydroxy-phenyl)-benzooxazol-5-ol DMNTHK5 MI TTZAYWL DMNTHK5 MN Estrogen receptor (ESR) DMNTHK5 MT DTT DMNTHK5 MA Inhibitor DMNTHK5 RN Design and synthesis of aryl diphenolic azoles as potent and selective estrogen receptor-beta ligands. J Med Chem. 2004 Oct 7;47(21):5021-40. DMNTHK5 RU https://pubmed.ncbi.nlm.nih.gov/15456246 DMNTHK5 DI DMNTHK5 DMNTHK5 DN 2-(3-Fluoro-4-hydroxy-phenyl)-benzooxazol-5-ol DMNTHK5 MI TTOM3J0 DMNTHK5 MN Estrogen receptor beta (ESR2) DMNTHK5 MT DTT DMNTHK5 MA Inhibitor DMNTHK5 RN Design and synthesis of aryl diphenolic azoles as potent and selective estrogen receptor-beta ligands. J Med Chem. 2004 Oct 7;47(21):5021-40. DMNTHK5 RU https://pubmed.ncbi.nlm.nih.gov/15456246 DM50FW1 DI DM50FW1 DM50FW1 DN 2-(3-Fluoro-4-hydroxy-phenyl)-benzooxazol-6-ol DM50FW1 MI TTZAYWL DM50FW1 MN Estrogen receptor (ESR) DM50FW1 MT DTT DM50FW1 MA Inhibitor DM50FW1 RN Design and synthesis of aryl diphenolic azoles as potent and selective estrogen receptor-beta ligands. J Med Chem. 2004 Oct 7;47(21):5021-40. DM50FW1 RU https://pubmed.ncbi.nlm.nih.gov/15456246 DM50FW1 DI DM50FW1 DM50FW1 DN 2-(3-Fluoro-4-hydroxy-phenyl)-benzooxazol-6-ol DM50FW1 MI TTOM3J0 DM50FW1 MN Estrogen receptor beta (ESR2) DM50FW1 MT DTT DM50FW1 MA Inhibitor DM50FW1 RN Design and synthesis of aryl diphenolic azoles as potent and selective estrogen receptor-beta ligands. J Med Chem. 2004 Oct 7;47(21):5021-40. DM50FW1 RU https://pubmed.ncbi.nlm.nih.gov/15456246 DMNYWAT DI DMNYWAT DMNYWAT DN 2-(3-Fluoro-phenyl)-benzo[h]chromen-4-one DMNYWAT MI TTK3PY9 DMNYWAT MN DNA-dependent protein kinase catalytic (PRKDC) DMNYWAT MT DTT DMNYWAT MA Inhibitor DMNYWAT RN Selective benzopyranone and pyrimido[2,1-a]isoquinolin-4-one inhibitors of DNA-dependent protein kinase: synthesis, structure-activity studies, and... J Med Chem. 2005 Jan 27;48(2):569-85. DMNYWAT RU https://pubmed.ncbi.nlm.nih.gov/15658870 DMZX2GE DI DMZX2GE DMZX2GE DN 2-(3-guanidinophenyl)-3-mercaptopropanoic acid DMZX2GE MI TTP18AY DMZX2GE MN Carboxypeptidase B2 (CPB2) DMZX2GE MT DTT DMZX2GE MA Inhibitor DMZX2GE RN 3-Mercaptopropionic acids as efficacious inhibitors of activated thrombin activatable fibrinolysis inhibitor (TAFIa). Bioorg Med Chem Lett. 2007 Mar 1;17(5):1349-54. DMZX2GE RU https://pubmed.ncbi.nlm.nih.gov/17189688 DMFVITM DI DMFVITM DMFVITM DN 2-(3-Hydroxycarbamoyl-propyl)-pentanedioic acid DMFVITM MI TT9G4N0 DMFVITM MN Glutamate carboxypeptidase II (GCPII) DMFVITM MT DTT DMFVITM MA Inhibitor DMFVITM RN Synthesis and biological evaluation of hydroxamate-Based inhibitors of glutamate carboxypeptidase II. Bioorg Med Chem Lett. 2003 Jul 7;13(13):2097-100. DMFVITM RU https://pubmed.ncbi.nlm.nih.gov/12798312 DMZCE18 DI DMZCE18 DMZCE18 DN 2-(3-hydroxyphenyl)-1,2'-spirobi[1H-indene]-5-ol DMZCE18 MI TTZAYWL DMZCE18 MN Estrogen receptor (ESR) DMZCE18 MT DTT DMZCE18 MA Inhibitor DMZCE18 RN 2-Phenylspiroindenes: a novel class of selective estrogen receptor modulators (SERMs). Bioorg Med Chem Lett. 2003 Feb 10;13(3):479-83. DMZCE18 RU https://pubmed.ncbi.nlm.nih.gov/12565955 DMZCE18 DI DMZCE18 DMZCE18 DN 2-(3-hydroxyphenyl)-1,2'-spirobi[1H-indene]-5-ol DMZCE18 MI TTOM3J0 DMZCE18 MN Estrogen receptor beta (ESR2) DMZCE18 MT DTT DMZCE18 MA Inhibitor DMZCE18 RN 2-Phenylspiroindenes: a novel class of selective estrogen receptor modulators (SERMs). Bioorg Med Chem Lett. 2003 Feb 10;13(3):479-83. DMZCE18 RU https://pubmed.ncbi.nlm.nih.gov/12565955 DMIGXRJ DI DMIGXRJ DMIGXRJ DN 2-(3-hydroxyphenyl)-1,2'-spirobi[1H-indene]-6-ol DMIGXRJ MI TTZAYWL DMIGXRJ MN Estrogen receptor (ESR) DMIGXRJ MT DTT DMIGXRJ MA Inhibitor DMIGXRJ RN 2-Phenylspiroindenes: a novel class of selective estrogen receptor modulators (SERMs). Bioorg Med Chem Lett. 2003 Feb 10;13(3):479-83. DMIGXRJ RU https://pubmed.ncbi.nlm.nih.gov/12565955 DMIGXRJ DI DMIGXRJ DMIGXRJ DN 2-(3-hydroxyphenyl)-1,2'-spirobi[1H-indene]-6-ol DMIGXRJ MI TTOM3J0 DMIGXRJ MN Estrogen receptor beta (ESR2) DMIGXRJ MT DTT DMIGXRJ MA Inhibitor DMIGXRJ RN 2-Phenylspiroindenes: a novel class of selective estrogen receptor modulators (SERMs). Bioorg Med Chem Lett. 2003 Feb 10;13(3):479-83. DMIGXRJ RU https://pubmed.ncbi.nlm.nih.gov/12565955 DM40RS3 DI DM40RS3 DM40RS3 DN 2-(3-Hydroxy-phenyl)-6-methyl-chromen-4-one DM40RS3 MI TTNJYV2 DM40RS3 MN Gamma-aminobutyric acid receptor (GAR) DM40RS3 MT DTT DM40RS3 MA Inhibitor DM40RS3 RN Refinement and evaluation of a pharmacophore model for flavone derivatives binding to the benzodiazepine site of the GABA(A) receptor. J Med Chem. 2002 Sep 12;45(19):4188-201. DM40RS3 RU https://pubmed.ncbi.nlm.nih.gov/12213060 DMAH0ZG DI DMAH0ZG DMAH0ZG DN 2-(3-hydroxyphenyl)-7-methoxychroman-4-one DMAH0ZG MI TTSZLWK DMAH0ZG MN Aromatase (CYP19A1) DMAH0ZG MT DTT DMAH0ZG MA Inhibitor DMAH0ZG RN New 7,8-benzoflavanones as potent aromatase inhibitors: synthesis and biological evaluation. Bioorg Med Chem. 2008 Feb 1;16(3):1474-80. DMAH0ZG RU https://pubmed.ncbi.nlm.nih.gov/18042388 DMV9M57 DI DMV9M57 DMV9M57 DN 2-(3-hydroxyphenyl)quinolin-6-ol DMV9M57 MI TTIWB6L DMV9M57 MN Estradiol 17 beta-dehydrogenase 1 (17-beta-HSD1) DMV9M57 MT DTT DMV9M57 MA Inhibitor DMV9M57 RN Design, synthesis, and biological evaluation of (hydroxyphenyl)naphthalene and -quinoline derivatives: potent and selective nonsteroidal inhibitors... J Med Chem. 2008 Apr 10;51(7):2158-69. DMV9M57 RU https://pubmed.ncbi.nlm.nih.gov/18324762 DMXRAE3 DI DMXRAE3 DMXRAE3 DN 2-(3''-indolylethyloxy)adenosine DMXRAE3 MI TTK25J1 DMXRAE3 MN Adenosine A1 receptor (ADORA1) DMXRAE3 MT DTT DMXRAE3 MA Inhibitor DMXRAE3 RN Structure-activity relationships of 2,N(6),5'-substituted adenosine derivatives with potent activity at the A2B adenosine receptor. J Med Chem. 2007 Apr 19;50(8):1810-27. DMXRAE3 RU https://pubmed.ncbi.nlm.nih.gov/17378544 DMXRAE3 DI DMXRAE3 DMXRAE3 DN 2-(3''-indolylethyloxy)adenosine DMXRAE3 MI TTM2AOE DMXRAE3 MN Adenosine A2a receptor (ADORA2A) DMXRAE3 MT DTT DMXRAE3 MA Inhibitor DMXRAE3 RN Structure-activity relationships of 2,N(6),5'-substituted adenosine derivatives with potent activity at the A2B adenosine receptor. J Med Chem. 2007 Apr 19;50(8):1810-27. DMXRAE3 RU https://pubmed.ncbi.nlm.nih.gov/17378544 DMXRAE3 DI DMXRAE3 DMXRAE3 DN 2-(3''-indolylethyloxy)adenosine DMXRAE3 MI TTJFY5U DMXRAE3 MN Adenosine A3 receptor (ADORA3) DMXRAE3 MT DTT DMXRAE3 MA Inhibitor DMXRAE3 RN Structure-activity relationships of 2,N(6),5'-substituted adenosine derivatives with potent activity at the A2B adenosine receptor. J Med Chem. 2007 Apr 19;50(8):1810-27. DMXRAE3 RU https://pubmed.ncbi.nlm.nih.gov/17378544 DMML0VP DI DMML0VP DMML0VP DN 2-(3-iodophenyl)histamine DMML0VP MI TTTIBOJ DMML0VP MN Histamine H1 receptor (H1R) DMML0VP MT DTT DMML0VP MA Agonist DMML0VP RN Multiple differences in agonist and antagonist pharmacology between human and guinea pig histamine H1-receptor. J Pharmacol Exp Ther. 2003 Jun;305(3):1104-15. DMML0VP RU https://pubmed.ncbi.nlm.nih.gov/12626648 DM59VBG DI DM59VBG DM59VBG DN 2-(3-Isobutyl-phenyl)-propionic acid DM59VBG MI TTMWT8Z DM59VBG MN C-X-C chemokine receptor type 1 (CXCR1) DM59VBG MT DTT DM59VBG MA Inhibitor DM59VBG RN 2-Arylpropionic CXC chemokine receptor 1 (CXCR1) ligands as novel noncompetitive CXCL8 inhibitors. J Med Chem. 2005 Jun 30;48(13):4312-31. DM59VBG RU https://pubmed.ncbi.nlm.nih.gov/15974585 DM59VBG DI DM59VBG DM59VBG DN 2-(3-Isobutyl-phenyl)-propionic acid DM59VBG MI TT30C9G DM59VBG MN C-X-C chemokine receptor type 2 (CXCR2) DM59VBG MT DTT DM59VBG MA Inhibitor DM59VBG RN 2-Arylpropionic CXC chemokine receptor 1 (CXCR1) ligands as novel noncompetitive CXCL8 inhibitors. J Med Chem. 2005 Jun 30;48(13):4312-31. DM59VBG RU https://pubmed.ncbi.nlm.nih.gov/15974585 DMUOWNE DI DMUOWNE DMUOWNE DN 2-(3-Isopropyl-phenyl)-propionic acid DMUOWNE MI TTMWT8Z DMUOWNE MN C-X-C chemokine receptor type 1 (CXCR1) DMUOWNE MT DTT DMUOWNE MA Inhibitor DMUOWNE RN 2-Arylpropionic CXC chemokine receptor 1 (CXCR1) ligands as novel noncompetitive CXCL8 inhibitors. J Med Chem. 2005 Jun 30;48(13):4312-31. DMUOWNE RU https://pubmed.ncbi.nlm.nih.gov/15974585 DMUOWNE DI DMUOWNE DMUOWNE DN 2-(3-Isopropyl-phenyl)-propionic acid DMUOWNE MI TT30C9G DMUOWNE MN C-X-C chemokine receptor type 2 (CXCR2) DMUOWNE MT DTT DMUOWNE MA Inhibitor DMUOWNE RN 2-Arylpropionic CXC chemokine receptor 1 (CXCR1) ligands as novel noncompetitive CXCL8 inhibitors. J Med Chem. 2005 Jun 30;48(13):4312-31. DMUOWNE RU https://pubmed.ncbi.nlm.nih.gov/15974585 DMMDNA8 DI DMMDNA8 DMMDNA8 DN 2-(3-Mercapto-propyl)-pentanedioic acid DMMDNA8 MI TT9G4N0 DMMDNA8 MN Glutamate carboxypeptidase II (GCPII) DMMDNA8 MT DTT DMMDNA8 MA Inhibitor DMMDNA8 RN Synthesis and biological evaluation of thiol-based inhibitors of glutamate carboxypeptidase II: discovery of an orally active GCP II inhibitor. J Med Chem. 2003 May 8;46(10):1989-96. DMMDNA8 RU https://pubmed.ncbi.nlm.nih.gov/12723961 DM21MAU DI DM21MAU DM21MAU DN 2-(3-methoxybenzylthio)-2-phenylacetic acid DM21MAU MI TTLUQ8E DM21MAU MN Hormone sensitive lipase (LIPE) DM21MAU MT DTT DM21MAU MA Inhibitor DM21MAU RN Combining ligand-based pharmacophore modeling, quantitative structure-activity relationship analysis and in silico screening for the discovery of n... J Med Chem. 2008 Oct 23;51(20):6478-94. DM21MAU RU https://pubmed.ncbi.nlm.nih.gov/18808096 DMCDGAU DI DMCDGAU DMCDGAU DN 2-(3'-Methoxyphenyl) Benzimidazole-4-Carboxamide DMCDGAU MI TTVDSZ0 DMCDGAU MN Poly [ADP-ribose] polymerase 1 (PARP1) DMCDGAU MT DTT DMCDGAU MA Inhibitor DMCDGAU RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DMCDGAU RU https://pubmed.ncbi.nlm.nih.gov/10592235 DM4C9H2 DI DM4C9H2 DM4C9H2 DN 2-(3-Methoxy-phenyl)-1-methyl-ethylamine DM4C9H2 MI TTSQIFT DM4C9H2 MN 5-HT 1A receptor (HTR1A) DM4C9H2 MT DTT DM4C9H2 MA Inhibitor DM4C9H2 RN 5-HT1 and 5-HT2 binding characteristics of 1-(2,5-dimethoxy-4-bromophenyl)-2-aminopropane analogues. J Med Chem. 1986 Feb;29(2):194-9. DM4C9H2 RU https://pubmed.ncbi.nlm.nih.gov/3950904 DM4C9H2 DI DM4C9H2 DM4C9H2 DN 2-(3-Methoxy-phenyl)-1-methyl-ethylamine DM4C9H2 MI TT6MSOK DM4C9H2 MN 5-HT 1D receptor (HTR1D) DM4C9H2 MT DTT DM4C9H2 MA Inhibitor DM4C9H2 RN 5-HT1 and 5-HT2 binding characteristics of 1-(2,5-dimethoxy-4-bromophenyl)-2-aminopropane analogues. J Med Chem. 1986 Feb;29(2):194-9. DM4C9H2 RU https://pubmed.ncbi.nlm.nih.gov/3950904 DM4C9H2 DI DM4C9H2 DM4C9H2 DN 2-(3-Methoxy-phenyl)-1-methyl-ethylamine DM4C9H2 MI TTJQOD7 DM4C9H2 MN 5-HT 2A receptor (HTR2A) DM4C9H2 MT DTT DM4C9H2 MA Inhibitor DM4C9H2 RN 5-HT1 and 5-HT2 binding characteristics of 1-(2,5-dimethoxy-4-bromophenyl)-2-aminopropane analogues. J Med Chem. 1986 Feb;29(2):194-9. DM4C9H2 RU https://pubmed.ncbi.nlm.nih.gov/3950904 DMBGVEK DI DMBGVEK DMBGVEK DN 2-(3-Methoxy-phenyl)-6-methyl-chromen-4-one DMBGVEK MI TTNJYV2 DMBGVEK MN Gamma-aminobutyric acid receptor (GAR) DMBGVEK MT DTT DMBGVEK MA Inhibitor DMBGVEK RN Refinement and evaluation of a pharmacophore model for flavone derivatives binding to the benzodiazepine site of the GABA(A) receptor. J Med Chem. 2002 Sep 12;45(19):4188-201. DMBGVEK RU https://pubmed.ncbi.nlm.nih.gov/12213060 DMASH36 DI DMASH36 DMASH36 DN 2-(3-methoxyphenyl)-6-morpholino-4H-pyran-4-one DMASH36 MI TTK3PY9 DMASH36 MN DNA-dependent protein kinase catalytic (PRKDC) DMASH36 MT DTT DMASH36 MA Inhibitor DMASH36 RN Pyranone, thiopyranone, and pyridone inhibitors of phosphatidylinositol 3-kinase related kinases. Structure-activity relationships for DNA-dependen... J Med Chem. 2007 Apr 19;50(8):1958-72. DMASH36 RU https://pubmed.ncbi.nlm.nih.gov/17371003 DME09J2 DI DME09J2 DME09J2 DN 2-(3-Methyl-3H-imidazol-4-yl)-ethylamine DME09J2 MI TT9JNIC DME09J2 MN Histamine H3 receptor (H3R) DME09J2 MT DTT DME09J2 MA Inhibitor DME09J2 RN New acetylene based histamine H3 receptor antagonists derived from the marine natural product verongamine. Bioorg Med Chem Lett. 1998 May 19;8(10):1133-8. DME09J2 RU https://pubmed.ncbi.nlm.nih.gov/9871722 DMFOA6R DI DMFOA6R DMFOA6R DN 2-(3-Methyl-indole-1-sulfonyl)-benzoic acid DMFOA6R MI TTHWMFZ DMFOA6R MN Fatty acid-binding protein 4 (FABP4) DMFOA6R MT DTT DMFOA6R MA Inhibitor DMFOA6R RN Discovery of inhibitors of human adipocyte fatty acid-binding protein, a potential type 2 diabetes target. Bioorg Med Chem Lett. 2004 Sep 6;14(17):4445-8. DMFOA6R RU https://pubmed.ncbi.nlm.nih.gov/15357969 DM1J4MT DI DM1J4MT DM1J4MT DN 2-(3-Methyl-piperazin-1-yl)-6-nitro-quinoline DM1J4MT MI TT3ROYC DM1J4MT MN Serotonin transporter (SERT) DM1J4MT MT DTT DM1J4MT MA Inhibitor DM1J4MT RN Syntheses and binding affinities of 6-nitroquipazine analogues for serotonin transporter. Part 1. Bioorg Med Chem Lett. 2000 Jul 17;10(14):1559-62. DM1J4MT RU https://pubmed.ncbi.nlm.nih.gov/10915050 DM4D1UT DI DM4D1UT DM4D1UT DN 2-(3-Methylsulfanyl-propyl)-pentanedioic acid DM4D1UT MI TT9G4N0 DM4D1UT MN Glutamate carboxypeptidase II (GCPII) DM4D1UT MT DTT DM4D1UT MA Inhibitor DM4D1UT RN Synthesis and biological evaluation of thiol-based inhibitors of glutamate carboxypeptidase II: discovery of an orally active GCP II inhibitor. J Med Chem. 2003 May 8;46(10):1989-96. DM4D1UT RU https://pubmed.ncbi.nlm.nih.gov/12723961 DMMYQ9R DI DMMYQ9R DMMYQ9R DN 2-(3-nitrophenyl)-4,5-dihydro-1H-imidazole DMMYQ9R MI TTGP7BY DMMYQ9R MN Monoamine oxidase type B (MAO-B) DMMYQ9R MT DTT DMMYQ9R MA Inhibitor DMMYQ9R RN Ultrasound promoted synthesis of 2-imidazolines in water: a greener approach toward monoamine oxidase inhibitors. Bioorg Med Chem Lett. 2009 Jan 15;19(2):546-9. DMMYQ9R RU https://pubmed.ncbi.nlm.nih.gov/19064321 DM6GLEA DI DM6GLEA DM6GLEA DN 2-(3-Phenoxy-benzoylamino)-benzoic acid DM6GLEA MI TTRVTMX DM6GLEA MN Bacterial Beta-ketoacyl-ACP synthase III (Bact fabH) DM6GLEA MT DTT DM6GLEA MA Inhibitor DM6GLEA RN Structure-based design, synthesis, and study of potent inhibitors of beta-ketoacyl-acyl carrier protein synthase III as potential antimicrobial age... J Med Chem. 2005 Mar 10;48(5):1596-609. DM6GLEA RU https://pubmed.ncbi.nlm.nih.gov/15743201 DMIQBXD DI DMIQBXD DMIQBXD DN 2-(3-Phenyl-propyl)-1,2-dihydro-indazol-3-one DMIQBXD MI TT2J34L DMIQBXD MN Arachidonate 5-lipoxygenase (5-LOX) DMIQBXD MT DTT DMIQBXD MA Inhibitor DMIQBXD RN Indazolinones, a new series of redox-active 5-lipoxygenase inhibitors with built-in selectivity and oral activity. J Med Chem. 1991 Mar;34(3):1028-36. DMIQBXD RU https://pubmed.ncbi.nlm.nih.gov/1848292 DMIQBXD DI DMIQBXD DMIQBXD DN 2-(3-Phenyl-propyl)-1,2-dihydro-indazol-3-one DMIQBXD MI TT8NGED DMIQBXD MN Prostaglandin G/H synthase 1 (COX-1) DMIQBXD MT DTT DMIQBXD MA Inhibitor DMIQBXD RN Indazolinones, a new series of redox-active 5-lipoxygenase inhibitors with built-in selectivity and oral activity. J Med Chem. 1991 Mar;34(3):1028-36. DMIQBXD RU https://pubmed.ncbi.nlm.nih.gov/1848292 DMIQBXD DI DMIQBXD DMIQBXD DN 2-(3-Phenyl-propyl)-1,2-dihydro-indazol-3-one DMIQBXD MI TTVKILB DMIQBXD MN Prostaglandin G/H synthase 2 (COX-2) DMIQBXD MT DTT DMIQBXD MA Inhibitor DMIQBXD RN Indazolinones, a new series of redox-active 5-lipoxygenase inhibitors with built-in selectivity and oral activity. J Med Chem. 1991 Mar;34(3):1028-36. DMIQBXD RU https://pubmed.ncbi.nlm.nih.gov/1848292 DM4WOT6 DI DM4WOT6 DM4WOT6 DN 2-(3-phenylthio)phenyl)-1-aminoethane DM4WOT6 MI TTJS8PY DM4WOT6 MN 5-HT 6 receptor (HTR6) DM4WOT6 MT DTT DM4WOT6 MA Inhibitor DM4WOT6 RN Binding of sulfonyl-containing arylalkylamines at human 5-HT6 serotonin receptors. J Med Chem. 2006 Aug 24;49(17):5217-25. DM4WOT6 RU https://pubmed.ncbi.nlm.nih.gov/16913710 DMZ5H8O DI DMZ5H8O DMZ5H8O DN 2-(3-Piperidin-1-yl-propyl)-3H-quinazolin-4-one DMZ5H8O MI TTVDSZ0 DMZ5H8O MN Poly [ADP-ribose] polymerase 1 (PARP1) DMZ5H8O MT DTT DMZ5H8O MA Inhibitor DMZ5H8O RN Rational approaches to discovery of orally active and brain-penetrable quinazolinone inhibitors of poly(ADP-ribose)polymerase. J Med Chem. 2004 Aug 12;47(17):4151-4. DMZ5H8O RU https://pubmed.ncbi.nlm.nih.gov/15293985 DMNCP8Y DI DMNCP8Y DMNCP8Y DN 2-(3''-pyrrolylethyloxy)adenosine DMNCP8Y MI TTK25J1 DMNCP8Y MN Adenosine A1 receptor (ADORA1) DMNCP8Y MT DTT DMNCP8Y MA Inhibitor DMNCP8Y RN Structure-activity relationships of 2,N(6),5'-substituted adenosine derivatives with potent activity at the A2B adenosine receptor. J Med Chem. 2007 Apr 19;50(8):1810-27. DMNCP8Y RU https://pubmed.ncbi.nlm.nih.gov/17378544 DMNCP8Y DI DMNCP8Y DMNCP8Y DN 2-(3''-pyrrolylethyloxy)adenosine DMNCP8Y MI TTM2AOE DMNCP8Y MN Adenosine A2a receptor (ADORA2A) DMNCP8Y MT DTT DMNCP8Y MA Inhibitor DMNCP8Y RN Structure-activity relationships of 2,N(6),5'-substituted adenosine derivatives with potent activity at the A2B adenosine receptor. J Med Chem. 2007 Apr 19;50(8):1810-27. DMNCP8Y RU https://pubmed.ncbi.nlm.nih.gov/17378544 DMNCP8Y DI DMNCP8Y DMNCP8Y DN 2-(3''-pyrrolylethyloxy)adenosine DMNCP8Y MI TTJFY5U DMNCP8Y MN Adenosine A3 receptor (ADORA3) DMNCP8Y MT DTT DMNCP8Y MA Inhibitor DMNCP8Y RN Structure-activity relationships of 2,N(6),5'-substituted adenosine derivatives with potent activity at the A2B adenosine receptor. J Med Chem. 2007 Apr 19;50(8):1810-27. DMNCP8Y RU https://pubmed.ncbi.nlm.nih.gov/17378544 DM7NGV1 DI DM7NGV1 DM7NGV1 DN 2-(3'-Vinyl-biphenyl-4-yl)-propionic acid DM7NGV1 MI TT8NGED DM7NGV1 MN Prostaglandin G/H synthase 1 (COX-1) DM7NGV1 MT DTT DM7NGV1 MA Inhibitor DM7NGV1 RN Structure-based design of COX-2 selectivity into flurbiprofen. Bioorg Med Chem Lett. 1999 Feb 8;9(3):307-12. DM7NGV1 RU https://pubmed.ncbi.nlm.nih.gov/10091674 DM27CQJ DI DM27CQJ DM27CQJ DN 2-(4-(3-chlorophenyl)but-1-ynyl)-6-methylpyridine DM27CQJ MI TTHS256 DM27CQJ MN Metabotropic glutamate receptor 5 (mGluR5) DM27CQJ MT DTT DM27CQJ MA Inhibitor DM27CQJ RN Structure-activity relationships for the linker in a series of pyridinyl-alkynes that are antagonists of the metabotropic glutamate receptor 5 (mGl... Bioorg Med Chem Lett. 2006 Sep 15;16(18):4788-91. DM27CQJ RU https://pubmed.ncbi.nlm.nih.gov/16837196 DMOYT8I DI DMOYT8I DMOYT8I DN 2-(4-(4-Hydroxyphenyl)thiazol-2-ylamino)phenol DMOYT8I MI TTWHDVK DMOYT8I MN Fructose-1,6-bisphosphatase (FBP) DMOYT8I MT DTT DMOYT8I MA Inhibitor DMOYT8I RN A library of novel allosteric inhibitors against fructose 1,6-bisphosphatase. Bioorg Med Chem. 2009 Jun 1;17(11):3916-22. DMOYT8I RU https://pubmed.ncbi.nlm.nih.gov/19419876 DMDAO5T DI DMDAO5T DMDAO5T DN 2-(4-(benzenesulfonyl)phenyl)-1-aminoethane DMDAO5T MI TTJS8PY DMDAO5T MN 5-HT 6 receptor (HTR6) DMDAO5T MT DTT DMDAO5T MA Inhibitor DMDAO5T RN Binding of sulfonyl-containing arylalkylamines at human 5-HT6 serotonin receptors. J Med Chem. 2006 Aug 24;49(17):5217-25. DMDAO5T RU https://pubmed.ncbi.nlm.nih.gov/16913710 DMFNQZS DI DMFNQZS DMFNQZS DN 2-(4-(methylamino)phenyl)benzo[d]thiazol-6-ol DMFNQZS MI TTE4KHA DMFNQZS MN Amyloid beta A4 protein (APP) DMFNQZS MT DTT DMFNQZS MA Inhibitor DMFNQZS RN Synthesis of biphenyltrienes as probes for beta-amyloid plaques. J Med Chem. 2006 May 4;49(9):2841-4. DMFNQZS RU https://pubmed.ncbi.nlm.nih.gov/16640346 DMVD6HE DI DMVD6HE DMVD6HE DN 2-(4-(methylsulfonyl)phenyl)-3-phenylquinoline DMVD6HE MI TTVKILB DMVD6HE MN Prostaglandin G/H synthase 2 (COX-2) DMVD6HE MT DTT DMVD6HE MA Inhibitor DMVD6HE RN Design, synthesis and biological evaluation of new 2,3-diarylquinoline derivatives as selective cyclooxygenase-2 inhibitors. Bioorg Med Chem. 2010 Feb;18(3):1029-33. DMVD6HE RU https://pubmed.ncbi.nlm.nih.gov/20061161 DM1TZNK DI DM1TZNK DM1TZNK DN 2-(4-(methylsulfonyl)phenyl)pyridine DM1TZNK MI TTVKILB DM1TZNK MN Prostaglandin G/H synthase 2 (COX-2) DM1TZNK MT DTT DM1TZNK MA Inhibitor DM1TZNK RN Synthesis, anti-inflammatory activity, and in vitro antitumor effect of a novel class of cyclooxygenase inhibitors: 4-(aryloyl)phenyl methyl sulfones. J Med Chem. 2010 Sep 23;53(18):6560-71. DM1TZNK RU https://pubmed.ncbi.nlm.nih.gov/20804197 DM4X0SJ DI DM4X0SJ DM4X0SJ DN 2-(4,5-dihydro-1H-imidazol-2-yl)quinoline DM4X0SJ MI TT3WG5C DM4X0SJ MN Monoamine oxidase type A (MAO-A) DM4X0SJ MT DTT DM4X0SJ MA Inhibitor DM4X0SJ RN Ultrasound promoted synthesis of 2-imidazolines in water: a greener approach toward monoamine oxidase inhibitors. Bioorg Med Chem Lett. 2009 Jan 15;19(2):546-9. DM4X0SJ RU https://pubmed.ncbi.nlm.nih.gov/19064321 DM4X0SJ DI DM4X0SJ DM4X0SJ DN 2-(4,5-dihydro-1H-imidazol-2-yl)quinoline DM4X0SJ MI TTGP7BY DM4X0SJ MN Monoamine oxidase type B (MAO-B) DM4X0SJ MT DTT DM4X0SJ MA Inhibitor DM4X0SJ RN Ultrasound promoted synthesis of 2-imidazolines in water: a greener approach toward monoamine oxidase inhibitors. Bioorg Med Chem Lett. 2009 Jan 15;19(2):546-9. DM4X0SJ RU https://pubmed.ncbi.nlm.nih.gov/19064321 DM4BFHR DI DM4BFHR DM4BFHR DN 2-(4,5-Dihydroxy-indan-1-ylidene)-malononitrile DM4BFHR MI TTGKNB4 DM4BFHR MN Epidermal growth factor receptor (EGFR) DM4BFHR MT DTT DM4BFHR MA Inhibitor DM4BFHR RN Tyrphostins. 2. Heterocyclic and alpha-substituted benzylidenemalononitrile tyrphostins as potent inhibitors of EGF receptor and ErbB2/neu tyrosine... J Med Chem. 1991 Jun;34(6):1896-907. DM4BFHR RU https://pubmed.ncbi.nlm.nih.gov/1676428 DM1UBGQ DI DM1UBGQ DM1UBGQ DN 2-(4,6-dimethoxypyrimidin-2-yloxy)-5-hexylphenol DM1UBGQ MI TTVTX4N DM1UBGQ MN Bacterial Fatty acid synthetase I (Bact inhA) DM1UBGQ MT DTT DM1UBGQ MA Inhibitor DM1UBGQ RN Synthesis and in vitro antimycobacterial activity of B-ring modified diaryl ether InhA inhibitors. Bioorg Med Chem Lett. 2008 May 15;18(10):3029-33. DM1UBGQ RU https://pubmed.ncbi.nlm.nih.gov/18457948 DMUANX1 DI DMUANX1 DMUANX1 DN 2-(4-amino-2-chlorophenoxy)-5-chlorophenol DMUANX1 MI TTNX2CS DMUANX1 MN Plasmodium Enoyl-ACP reductase (Malaria fabI) DMUANX1 MT DTT DMUANX1 MA Inhibitor DMUANX1 RN Synthesis, biological activity, and X-ray crystal structural analysis of diaryl ether inhibitors of malarial enoyl acyl carrier protein reductase. ... Bioorg Med Chem Lett. 2005 Dec 1;15(23):5247-52. DMUANX1 RU https://pubmed.ncbi.nlm.nih.gov/16198563 DMSHPCW DI DMSHPCW DMSHPCW DN 2-(4-Amino-3'-chloro-biphenyl-3-yl)-propan-2-ol DMSHPCW MI TTUV8G9 DMSHPCW MN Progesterone receptor (PGR) DMSHPCW MT DTT DMSHPCW MA Inhibitor DMSHPCW RN Potent nonsteroidal progesterone receptor agonists: synthesis and SAR study of 6-aryl benzoxazines. Bioorg Med Chem Lett. 2002 Mar 11;12(5):787-90. DMSHPCW RU https://pubmed.ncbi.nlm.nih.gov/11859003 DMP0GI8 DI DMP0GI8 DMP0GI8 DN 2-(4-aminophenoxy)-5-hexylphenol DMP0GI8 MI TTVTX4N DMP0GI8 MN Bacterial Fatty acid synthetase I (Bact inhA) DMP0GI8 MT DTT DMP0GI8 MA Inhibitor DMP0GI8 RN Synthesis and in vitro antimycobacterial activity of B-ring modified diaryl ether InhA inhibitors. Bioorg Med Chem Lett. 2008 May 15;18(10):3029-33. DMP0GI8 RU https://pubmed.ncbi.nlm.nih.gov/18457948 DMGQHBU DI DMGQHBU DMGQHBU DN 2-(4-Amino-phenyl)-6-methyl-chromen-4-one DMGQHBU MI TTNJYV2 DMGQHBU MN Gamma-aminobutyric acid receptor (GAR) DMGQHBU MT DTT DMGQHBU MA Inhibitor DMGQHBU RN Refinement and evaluation of a pharmacophore model for flavone derivatives binding to the benzodiazepine site of the GABA(A) receptor. J Med Chem. 2002 Sep 12;45(19):4188-201. DMGQHBU RU https://pubmed.ncbi.nlm.nih.gov/12213060 DM7LBEG DI DM7LBEG DM7LBEG DN 2-(4-Amino-phenyl)-8-hydroxy-3H-quinazolin-4-one DM7LBEG MI TTVDSZ0 DM7LBEG MN Poly [ADP-ribose] polymerase 1 (PARP1) DM7LBEG MT DTT DM7LBEG MA Inhibitor DM7LBEG RN Resistance-modifying agents. 5. Synthesis and biological properties of quinazolinone inhibitors of the DNA repair enzyme poly(ADP-ribose) polymeras... J Med Chem. 1998 Dec 17;41(26):5247-56. DM7LBEG RU https://pubmed.ncbi.nlm.nih.gov/9857092 DMJRDAQ DI DMJRDAQ DMJRDAQ DN 2-(4-Amino-phenyl)-8-methyl-3H-quinazolin-4-one DMJRDAQ MI TTVDSZ0 DMJRDAQ MN Poly [ADP-ribose] polymerase 1 (PARP1) DMJRDAQ MT DTT DMJRDAQ MA Inhibitor DMJRDAQ RN Resistance-modifying agents. 5. Synthesis and biological properties of quinazolinone inhibitors of the DNA repair enzyme poly(ADP-ribose) polymeras... J Med Chem. 1998 Dec 17;41(26):5247-56. DMJRDAQ RU https://pubmed.ncbi.nlm.nih.gov/9857092 DM2P9L5 DI DM2P9L5 DM2P9L5 DN 2-(4-Amino-phenyl)-benzo[h]chromen-4-one DM2P9L5 MI TTK3PY9 DM2P9L5 MN DNA-dependent protein kinase catalytic (PRKDC) DM2P9L5 MT DTT DM2P9L5 MA Inhibitor DM2P9L5 RN Selective benzopyranone and pyrimido[2,1-a]isoquinolin-4-one inhibitors of DNA-dependent protein kinase: synthesis, structure-activity studies, and... J Med Chem. 2005 Jan 27;48(2):569-85. DM2P9L5 RU https://pubmed.ncbi.nlm.nih.gov/15658870 DMMU2BZ DI DMMU2BZ DMMU2BZ DN 2-(4-aminophenylsulfonamido)acetic acid DMMU2BZ MI TTFBNVI DMMU2BZ MN Aldose reductase (AKR1B1) DMMU2BZ MT DTT DMMU2BZ MA Inhibitor DMMU2BZ RN Design and synthesis of N-(3,5-difluoro-4-hydroxyphenyl)benzenesulfonamides as aldose reductase inhibitors. Bioorg Med Chem. 2008 Apr 1;16(7):3926-32. DMMU2BZ RU https://pubmed.ncbi.nlm.nih.gov/18267362 DM2JG49 DI DM2JG49 DM2JG49 DN 2-(4-Azido-phenyl)-8-methoxy-3H-quinazolin-4-one DM2JG49 MI TTVDSZ0 DM2JG49 MN Poly [ADP-ribose] polymerase 1 (PARP1) DM2JG49 MT DTT DM2JG49 MA Inhibitor DM2JG49 RN Resistance-modifying agents. 5. Synthesis and biological properties of quinazolinone inhibitors of the DNA repair enzyme poly(ADP-ribose) polymeras... J Med Chem. 1998 Dec 17;41(26):5247-56. DM2JG49 RU https://pubmed.ncbi.nlm.nih.gov/9857092 DMJA5Y4 DI DMJA5Y4 DMJA5Y4 DN 2-(4-benzoylpiperazin-1-yl)thiazole-5-carboxamide DMJA5Y4 MI TT6RIOV DMJA5Y4 MN Acyl-CoA desaturase (SCD) DMJA5Y4 MT DTT DMJA5Y4 MA Inhibitor DMJA5Y4 RN Thiazole analog as stearoyl-CoA desaturase 1 inhibitor. Bioorg Med Chem Lett. 2009 Sep 1;19(17):5214-7. DMJA5Y4 RU https://pubmed.ncbi.nlm.nih.gov/19632834 DMGMZV9 DI DMGMZV9 DMGMZV9 DN 2-(4-benzoylpiperidine-1-carbonyl)benzoic acid DMGMZV9 MI TTP18AY DMGMZV9 MN Carboxypeptidase B2 (CPB2) DMGMZV9 MT DTT DMGMZV9 MA Inhibitor DMGMZV9 RN A new type of five-membered heterocyclic inhibitors of basic metallocarboxypeptidases. Eur J Med Chem. 2009 Aug;44(8):3266-71. DMGMZV9 RU https://pubmed.ncbi.nlm.nih.gov/19386397 DM6R4MG DI DM6R4MG DM6R4MG DN 2-(4-benzylphenoxy)ethanamine DM6R4MG MI TTXZEAJ DM6R4MG MN Leukotriene A-4 hydrolase (LTA4H) DM6R4MG MT DTT DM6R4MG MA Inhibitor DM6R4MG RN Activation and inhibition of leukotriene A4 hydrolase aminopeptidase activity by diphenyl ether and derivatives. Bioorg Med Chem Lett. 2008 Dec 15;18(24):6549-52. DM6R4MG RU https://pubmed.ncbi.nlm.nih.gov/18952425 DM1V7EF DI DM1V7EF DM1V7EF DN 2-(4-Benzyl-piperazin-1-yl)-benzothiazole DM1V7EF MI TTPC4TU DM1V7EF MN 5-HT 3A receptor (HTR3A) DM1V7EF MT DTT DM1V7EF MA Inhibitor DM1V7EF RN Synthesis of 2-piperazinylbenzothiazole and 2-piperazinylbenzoxazole derivatives with 5-HT3 antagonist and 5-HT4 agonist properties. J Med Chem. 1994 Apr 29;37(9):1320-5. DM1V7EF RU https://pubmed.ncbi.nlm.nih.gov/8176710 DM1V7EF DI DM1V7EF DM1V7EF DN 2-(4-Benzyl-piperazin-1-yl)-benzothiazole DM1V7EF MI TTR6K75 DM1V7EF MN 5-HT 3B receptor (HTR3B) DM1V7EF MT DTT DM1V7EF MA Inhibitor DM1V7EF RN Synthesis of 2-piperazinylbenzothiazole and 2-piperazinylbenzoxazole derivatives with 5-HT3 antagonist and 5-HT4 agonist properties. J Med Chem. 1994 Apr 29;37(9):1320-5. DM1V7EF RU https://pubmed.ncbi.nlm.nih.gov/8176710 DMFGCS1 DI DMFGCS1 DMFGCS1 DN 2-(4-benzyl-piperidin-1-ylmethyl)-1H-indol-6-ol DMFGCS1 MI TTN9D8E DMFGCS1 MN Glutamate receptor ionotropic NMDA 2B (NMDAR2B) DMFGCS1 MT DTT DMFGCS1 MA Inhibitor DMFGCS1 RN Selective NR1/2B N-methyl-D-aspartate receptor antagonists among indole-2-carboxamides and benzimidazole-2-carboxamides. J Med Chem. 2007 Mar 8;50(5):901-14. DMFGCS1 RU https://pubmed.ncbi.nlm.nih.gov/17290978 DMID9YA DI DMID9YA DMID9YA DN 2-(4-Benzyl-piperidin-1-ylmethyl)-chroman-4-one DMID9YA MI TTSQIFT DMID9YA MN 5-HT 1A receptor (HTR1A) DMID9YA MT DTT DMID9YA MA Inhibitor DMID9YA RN Synthesis and structure-activity relationships of 1-aralkyl-4-benzylpiperidine and 1-aralkyl-4-benzylpiperazine derivatives as potent sigma ligands. J Med Chem. 2005 Jan 13;48(1):266-73. DMID9YA RU https://pubmed.ncbi.nlm.nih.gov/15634021 DM7QK5C DI DM7QK5C DM7QK5C DN 2-(4-bromo-2-(hydroxymethyl)phenoxy)acetic acid DM7QK5C MI TTQDMX5 DM7QK5C MN Prostaglandin D2 receptor 2 (PTGDR2) DM7QK5C MT DTT DM7QK5C MA Inhibitor DM7QK5C RN Novel selective orally active CRTH2 antagonists for allergic inflammation developed from in silico derived hits. J Med Chem. 2006 Nov 16;49(23):6638-41. DM7QK5C RU https://pubmed.ncbi.nlm.nih.gov/17154491 DM6I1NQ DI DM6I1NQ DM6I1NQ DN 2-(4-bromo-2-cyclohexylphenoxy)acetic acid DM6I1NQ MI TTQDMX5 DM6I1NQ MN Prostaglandin D2 receptor 2 (PTGDR2) DM6I1NQ MT DTT DM6I1NQ MA Inhibitor DM6I1NQ RN 2-Cycloalkyl phenoxyacetic acid CRTh2 receptor antagonists. Bioorg Med Chem Lett. 2007 Aug 1;17(15):4347-50. DM6I1NQ RU https://pubmed.ncbi.nlm.nih.gov/17531480 DMQVUZP DI DMQVUZP DMQVUZP DN 2-(4-bromo-2-formylphenoxy)acetic acid DMQVUZP MI TTQDMX5 DMQVUZP MN Prostaglandin D2 receptor 2 (PTGDR2) DMQVUZP MT DTT DMQVUZP MA Inhibitor DMQVUZP RN Novel selective orally active CRTH2 antagonists for allergic inflammation developed from in silico derived hits. J Med Chem. 2006 Nov 16;49(23):6638-41. DMQVUZP RU https://pubmed.ncbi.nlm.nih.gov/17154491 DM79JVK DI DM79JVK DM79JVK DN 2-(4-Bromo-2-methoxy-phenyl)-1-methyl-ethylamine DM79JVK MI TTSQIFT DM79JVK MN 5-HT 1A receptor (HTR1A) DM79JVK MT DTT DM79JVK MA Inhibitor DM79JVK RN 5-HT1 and 5-HT2 binding characteristics of 1-(2,5-dimethoxy-4-bromophenyl)-2-aminopropane analogues. J Med Chem. 1986 Feb;29(2):194-9. DM79JVK RU https://pubmed.ncbi.nlm.nih.gov/3950904 DM79JVK DI DM79JVK DM79JVK DN 2-(4-Bromo-2-methoxy-phenyl)-1-methyl-ethylamine DM79JVK MI TT6MSOK DM79JVK MN 5-HT 1D receptor (HTR1D) DM79JVK MT DTT DM79JVK MA Inhibitor DM79JVK RN 5-HT1 and 5-HT2 binding characteristics of 1-(2,5-dimethoxy-4-bromophenyl)-2-aminopropane analogues. J Med Chem. 1986 Feb;29(2):194-9. DM79JVK RU https://pubmed.ncbi.nlm.nih.gov/3950904 DM79JVK DI DM79JVK DM79JVK DN 2-(4-Bromo-2-methoxy-phenyl)-1-methyl-ethylamine DM79JVK MI TTJQOD7 DM79JVK MN 5-HT 2A receptor (HTR2A) DM79JVK MT DTT DM79JVK MA Inhibitor DM79JVK RN 5-HT1 and 5-HT2 binding characteristics of 1-(2,5-dimethoxy-4-bromophenyl)-2-aminopropane analogues. J Med Chem. 1986 Feb;29(2):194-9. DM79JVK RU https://pubmed.ncbi.nlm.nih.gov/3950904 DMXAQZ0 DI DMXAQZ0 DMXAQZ0 DN 2-(4-bromo-2-tert-butylphenoxy)acetic acid DMXAQZ0 MI TTQDMX5 DMXAQZ0 MN Prostaglandin D2 receptor 2 (PTGDR2) DMXAQZ0 MT DTT DMXAQZ0 MA Inhibitor DMXAQZ0 RN Novel selective orally active CRTH2 antagonists for allergic inflammation developed from in silico derived hits. J Med Chem. 2006 Nov 16;49(23):6638-41. DMXAQZ0 RU https://pubmed.ncbi.nlm.nih.gov/17154491 DMY8GZP DI DMY8GZP DMY8GZP DN 2-(4-Bromo-3-phenoxy-benzoylamino)-benzoic acid DMY8GZP MI TTRVTMX DMY8GZP MN Bacterial Beta-ketoacyl-ACP synthase III (Bact fabH) DMY8GZP MT DTT DMY8GZP MA Inhibitor DMY8GZP RN Structure-based design, synthesis, and study of potent inhibitors of beta-ketoacyl-acyl carrier protein synthase III as potential antimicrobial age... J Med Chem. 2005 Mar 10;48(5):1596-609. DMY8GZP RU https://pubmed.ncbi.nlm.nih.gov/15743201 DMB49UP DI DMB49UP DMB49UP DN 2-(4-Bromo-phenyl)-1-methyl-ethylamine DMB49UP MI TTSQIFT DMB49UP MN 5-HT 1A receptor (HTR1A) DMB49UP MT DTT DMB49UP MA Inhibitor DMB49UP RN 5-HT1 and 5-HT2 binding characteristics of 1-(2,5-dimethoxy-4-bromophenyl)-2-aminopropane analogues. J Med Chem. 1986 Feb;29(2):194-9. DMB49UP RU https://pubmed.ncbi.nlm.nih.gov/3950904 DMB49UP DI DMB49UP DMB49UP DN 2-(4-Bromo-phenyl)-1-methyl-ethylamine DMB49UP MI TT6MSOK DMB49UP MN 5-HT 1D receptor (HTR1D) DMB49UP MT DTT DMB49UP MA Inhibitor DMB49UP RN 5-HT1 and 5-HT2 binding characteristics of 1-(2,5-dimethoxy-4-bromophenyl)-2-aminopropane analogues. J Med Chem. 1986 Feb;29(2):194-9. DMB49UP RU https://pubmed.ncbi.nlm.nih.gov/3950904 DMB49UP DI DMB49UP DMB49UP DN 2-(4-Bromo-phenyl)-1-methyl-ethylamine DMB49UP MI TTJQOD7 DMB49UP MN 5-HT 2A receptor (HTR2A) DMB49UP MT DTT DMB49UP MA Inhibitor DMB49UP RN 5-HT1 and 5-HT2 binding characteristics of 1-(2,5-dimethoxy-4-bromophenyl)-2-aminopropane analogues. J Med Chem. 1986 Feb;29(2):194-9. DMB49UP RU https://pubmed.ncbi.nlm.nih.gov/3950904 DMY5STK DI DMY5STK DMY5STK DN 2-(4-bromophenylsulfonamido)-N-hydroxyacetamide DMY5STK MI TTJ4QE7 DMY5STK MN Matrix metalloproteinase-14 (MMP-14) DMY5STK MT DTT DMY5STK MA Inhibitor DMY5STK RN Potent arylsulfonamide inhibitors of tumor necrosis factor-alpha converting enzyme able to reduce activated leukocyte cell adhesion molecule sheddi... J Med Chem. 2010 Mar 25;53(6):2622-35. DMY5STK RU https://pubmed.ncbi.nlm.nih.gov/20180536 DMY5STK DI DMY5STK DMY5STK DN 2-(4-bromophenylsulfonamido)-N-hydroxyacetamide DMY5STK MI TT6AZXG DMY5STK MN TNF alpha converting enzyme (ADAM17) DMY5STK MT DTT DMY5STK MA Inhibitor DMY5STK RN Potent arylsulfonamide inhibitors of tumor necrosis factor-alpha converting enzyme able to reduce activated leukocyte cell adhesion molecule sheddi... J Med Chem. 2010 Mar 25;53(6):2622-35. DMY5STK RU https://pubmed.ncbi.nlm.nih.gov/20180536 DMG32HQ DI DMG32HQ DMG32HQ DN 2-(4-Butoxy-phenoxy)-N-hydroxy-acetamide DMG32HQ MI TT2J34L DMG32HQ MN Arachidonate 5-lipoxygenase (5-LOX) DMG32HQ MT DTT DMG32HQ MA Inhibitor DMG32HQ RN Hydroxamic acid inhibitors of 5-lipoxygenase: quantitative structure-activity relationships. J Med Chem. 1990 Mar;33(3):992-8. DMG32HQ RU https://pubmed.ncbi.nlm.nih.gov/2308149 DMEKNZW DI DMEKNZW DMEKNZW DN 2-(4-Butoxy-phenoxy)-N-hydroxy-N-methyl-acetamide DMEKNZW MI TT2J34L DMEKNZW MN Arachidonate 5-lipoxygenase (5-LOX) DMEKNZW MT DTT DMEKNZW MA Inhibitor DMEKNZW RN Hydroxamic acid inhibitors of 5-lipoxygenase: quantitative structure-activity relationships. J Med Chem. 1990 Mar;33(3):992-8. DMEKNZW RU https://pubmed.ncbi.nlm.nih.gov/2308149 DMO5IM0 DI DMO5IM0 DMO5IM0 DN 2-(4-Butoxy-phenoxy)-N-hydroxy-propionamide DMO5IM0 MI TT2J34L DMO5IM0 MN Arachidonate 5-lipoxygenase (5-LOX) DMO5IM0 MT DTT DMO5IM0 MA Inhibitor DMO5IM0 RN Hydroxamic acid inhibitors of 5-lipoxygenase: quantitative structure-activity relationships. J Med Chem. 1990 Mar;33(3):992-8. DMO5IM0 RU https://pubmed.ncbi.nlm.nih.gov/2308149 DMP7CF8 DI DMP7CF8 DMP7CF8 DN 2-(4-Butoxy-phenyl)-N-hydroxy-N-methyl-acetamide DMP7CF8 MI TT2J34L DMP7CF8 MN Arachidonate 5-lipoxygenase (5-LOX) DMP7CF8 MT DTT DMP7CF8 MA Inhibitor DMP7CF8 RN Hydroxamic acid inhibitors of 5-lipoxygenase: quantitative structure-activity relationships. J Med Chem. 1990 Mar;33(3):992-8. DMP7CF8 RU https://pubmed.ncbi.nlm.nih.gov/2308149 DM2XFGJ DI DM2XFGJ DM2XFGJ DN 2-(4-CARCOXY-5-ISOPROPYLTHIAZOLYL)BENZOPIPERIDINE DM2XFGJ MI TT6PKBN DM2XFGJ MN Proto-oncogene c-Src (SRC) DM2XFGJ MT DTT DM2XFGJ MA Inhibitor DM2XFGJ RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DM2XFGJ RU https://pubmed.ncbi.nlm.nih.gov/10592235 DM7BHYS DI DM7BHYS DM7BHYS DN 2-(4-chloro-1H-benzo[d]imidazol-2-yl)quinoxaline DM7BHYS MI TTK25J1 DM7BHYS MN Adenosine A1 receptor (ADORA1) DM7BHYS MT DTT DM7BHYS MA Inhibitor DM7BHYS RN 2-(Benzimidazol-2-yl)quinoxalines: a novel class of selective antagonists at human A(1) and A(3) adenosine receptors designed by 3D database search... J Med Chem. 2005 Dec 29;48(26):8253-60. DM7BHYS RU https://pubmed.ncbi.nlm.nih.gov/16366607 DM7BHYS DI DM7BHYS DM7BHYS DN 2-(4-chloro-1H-benzo[d]imidazol-2-yl)quinoxaline DM7BHYS MI TTJFY5U DM7BHYS MN Adenosine A3 receptor (ADORA3) DM7BHYS MT DTT DM7BHYS MA Inhibitor DM7BHYS RN 2-(Benzimidazol-2-yl)quinoxalines: a novel class of selective antagonists at human A(1) and A(3) adenosine receptors designed by 3D database search... J Med Chem. 2005 Dec 29;48(26):8253-60. DM7BHYS RU https://pubmed.ncbi.nlm.nih.gov/16366607 DM15YM7 DI DM15YM7 DM15YM7 DN 2-(4-chloro-2-cycloheptylphenoxy)acetic acid DM15YM7 MI TTQDMX5 DM15YM7 MN Prostaglandin D2 receptor 2 (PTGDR2) DM15YM7 MT DTT DM15YM7 MA Inhibitor DM15YM7 RN 7-Azaindole-3-acetic acid derivatives: potent and selective CRTh2 receptor antagonists. Bioorg Med Chem Lett. 2009 Aug 15;19(16):4794-8. DM15YM7 RU https://pubmed.ncbi.nlm.nih.gov/19592244 DMGYZ8D DI DMGYZ8D DMGYZ8D DN 2-(4-chloro-2-cyclohexylphenoxy)acetic acid DMGYZ8D MI TTQDMX5 DMGYZ8D MN Prostaglandin D2 receptor 2 (PTGDR2) DMGYZ8D MT DTT DMGYZ8D MA Inhibitor DMGYZ8D RN 2-Cycloalkyl phenoxyacetic acid CRTh2 receptor antagonists. Bioorg Med Chem Lett. 2007 Aug 1;17(15):4347-50. DMGYZ8D RU https://pubmed.ncbi.nlm.nih.gov/17531480 DMA6KQU DI DMA6KQU DMA6KQU DN 2-(4-chloro-2-cyclopentylphenoxy)acetic acid DMA6KQU MI TTQDMX5 DMA6KQU MN Prostaglandin D2 receptor 2 (PTGDR2) DMA6KQU MT DTT DMA6KQU MA Inhibitor DMA6KQU RN 2-Cycloalkyl phenoxyacetic acid CRTh2 receptor antagonists. Bioorg Med Chem Lett. 2007 Aug 1;17(15):4347-50. DMA6KQU RU https://pubmed.ncbi.nlm.nih.gov/17531480 DMBHFIM DI DMBHFIM DMBHFIM DN 2-(4-chloro-2-hydroxyphenoxy)benzenaminium DMBHFIM MI TTNX2CS DMBHFIM MN Plasmodium Enoyl-ACP reductase (Malaria fabI) DMBHFIM MT DTT DMBHFIM MA Inhibitor DMBHFIM RN Design and in silico screening of combinatorial library of antimalarial analogs of triclosan inhibiting Plasmodium falciparum enoyl-acyl carrier pr... Eur J Med Chem. 2009 Jul;44(7):3009-19. DMBHFIM RU https://pubmed.ncbi.nlm.nih.gov/19217192 DMOH2YC DI DMOH2YC DMOH2YC DN 2-(4-Chlorobenzylidene)cyclopentanone DMOH2YC MI TT5ZWB6 DMOH2YC MN Dihydrodiol dehydrogenase type I (AKR1C3) DMOH2YC MT DTT DMOH2YC MA Inhibitor DMOH2YC RN New cyclopentane derivatives as inhibitors of steroid metabolizing enzymes AKR1C1 and AKR1C3. Eur J Med Chem. 2009 Jun;44(6):2563-71. DMOH2YC RU https://pubmed.ncbi.nlm.nih.gov/19237229 DMFE93N DI DMFE93N DMFE93N DN 2-(4-chlorobenzylidene)cyclopentyl ethyl ether DMFE93N MI TT5ZWB6 DMFE93N MN Dihydrodiol dehydrogenase type I (AKR1C3) DMFE93N MT DTT DMFE93N MA Inhibitor DMFE93N RN New cyclopentane derivatives as inhibitors of steroid metabolizing enzymes AKR1C1 and AKR1C3. Eur J Med Chem. 2009 Jun;44(6):2563-71. DMFE93N RU https://pubmed.ncbi.nlm.nih.gov/19237229 DMTW9B7 DI DMTW9B7 DMTW9B7 DN 2-(4-chlorobenzylidene)cyclopentylmethyl ether DMTW9B7 MI TT5ZWB6 DMTW9B7 MN Dihydrodiol dehydrogenase type I (AKR1C3) DMTW9B7 MT DTT DMTW9B7 MA Inhibitor DMTW9B7 RN New cyclopentane derivatives as inhibitors of steroid metabolizing enzymes AKR1C1 and AKR1C3. Eur J Med Chem. 2009 Jun;44(6):2563-71. DMTW9B7 RU https://pubmed.ncbi.nlm.nih.gov/19237229 DM1JKWL DI DM1JKWL DM1JKWL DN 2-(4-chlorobenzyloxyamino)-N-hydroxyacetamide DM1JKWL MI TTHQPL7 DM1JKWL MN Carbonic anhydrase I (CA-I) DM1JKWL MT DTT DM1JKWL MA Inhibitor DM1JKWL RN Carbonic anhydrase and matrix metalloproteinase inhibitors. Inhibition of human tumor-associated isozymes IX and cytosolic isozyme I and II with su... Bioorg Med Chem. 2007 Mar 15;15(6):2298-311. DM1JKWL RU https://pubmed.ncbi.nlm.nih.gov/17276072 DM1JKWL DI DM1JKWL DM1JKWL DN 2-(4-chlorobenzyloxyamino)-N-hydroxyacetamide DM1JKWL MI TTANPDJ DM1JKWL MN Carbonic anhydrase II (CA-II) DM1JKWL MT DTT DM1JKWL MA Inhibitor DM1JKWL RN Carbonic anhydrase and matrix metalloproteinase inhibitors. Inhibition of human tumor-associated isozymes IX and cytosolic isozyme I and II with su... Bioorg Med Chem. 2007 Mar 15;15(6):2298-311. DM1JKWL RU https://pubmed.ncbi.nlm.nih.gov/17276072 DM1JKWL DI DM1JKWL DM1JKWL DN 2-(4-chlorobenzyloxyamino)-N-hydroxyacetamide DM1JKWL MI TT2LVK8 DM1JKWL MN Carbonic anhydrase IX (CA-IX) DM1JKWL MT DTT DM1JKWL MA Inhibitor DM1JKWL RN Carbonic anhydrase and matrix metalloproteinase inhibitors. Inhibition of human tumor-associated isozymes IX and cytosolic isozyme I and II with su... Bioorg Med Chem. 2007 Mar 15;15(6):2298-311. DM1JKWL RU https://pubmed.ncbi.nlm.nih.gov/17276072 DMFGQ7K DI DMFGQ7K DMFGQ7K DN 2-(4-chlorobenzyloxyamino)-N-hydroxyhexanamide DMFGQ7K MI TTHQPL7 DMFGQ7K MN Carbonic anhydrase I (CA-I) DMFGQ7K MT DTT DMFGQ7K MA Inhibitor DMFGQ7K RN Carbonic anhydrase and matrix metalloproteinase inhibitors. Inhibition of human tumor-associated isozymes IX and cytosolic isozyme I and II with su... Bioorg Med Chem. 2007 Mar 15;15(6):2298-311. DMFGQ7K RU https://pubmed.ncbi.nlm.nih.gov/17276072 DMFGQ7K DI DMFGQ7K DMFGQ7K DN 2-(4-chlorobenzyloxyamino)-N-hydroxyhexanamide DMFGQ7K MI TTANPDJ DMFGQ7K MN Carbonic anhydrase II (CA-II) DMFGQ7K MT DTT DMFGQ7K MA Inhibitor DMFGQ7K RN Carbonic anhydrase and matrix metalloproteinase inhibitors. Inhibition of human tumor-associated isozymes IX and cytosolic isozyme I and II with su... Bioorg Med Chem. 2007 Mar 15;15(6):2298-311. DMFGQ7K RU https://pubmed.ncbi.nlm.nih.gov/17276072 DMFGQ7K DI DMFGQ7K DMFGQ7K DN 2-(4-chlorobenzyloxyamino)-N-hydroxyhexanamide DMFGQ7K MI TT2LVK8 DMFGQ7K MN Carbonic anhydrase IX (CA-IX) DMFGQ7K MT DTT DMFGQ7K MA Inhibitor DMFGQ7K RN Carbonic anhydrase and matrix metalloproteinase inhibitors. Inhibition of human tumor-associated isozymes IX and cytosolic isozyme I and II with su... Bioorg Med Chem. 2007 Mar 15;15(6):2298-311. DMFGQ7K RU https://pubmed.ncbi.nlm.nih.gov/17276072 DMRADWB DI DMRADWB DMRADWB DN 2-(4-chlorobenzyloxyamino)-N-hydroxypropanamide DMRADWB MI TTHQPL7 DMRADWB MN Carbonic anhydrase I (CA-I) DMRADWB MT DTT DMRADWB MA Inhibitor DMRADWB RN Carbonic anhydrase and matrix metalloproteinase inhibitors. Inhibition of human tumor-associated isozymes IX and cytosolic isozyme I and II with su... Bioorg Med Chem. 2007 Mar 15;15(6):2298-311. DMRADWB RU https://pubmed.ncbi.nlm.nih.gov/17276072 DMRADWB DI DMRADWB DMRADWB DN 2-(4-chlorobenzyloxyamino)-N-hydroxypropanamide DMRADWB MI TTANPDJ DMRADWB MN Carbonic anhydrase II (CA-II) DMRADWB MT DTT DMRADWB MA Inhibitor DMRADWB RN Carbonic anhydrase and matrix metalloproteinase inhibitors. Inhibition of human tumor-associated isozymes IX and cytosolic isozyme I and II with su... Bioorg Med Chem. 2007 Mar 15;15(6):2298-311. DMRADWB RU https://pubmed.ncbi.nlm.nih.gov/17276072 DMRADWB DI DMRADWB DMRADWB DN 2-(4-chlorobenzyloxyamino)-N-hydroxypropanamide DMRADWB MI TT2LVK8 DMRADWB MN Carbonic anhydrase IX (CA-IX) DMRADWB MT DTT DMRADWB MA Inhibitor DMRADWB RN Carbonic anhydrase and matrix metalloproteinase inhibitors. Inhibition of human tumor-associated isozymes IX and cytosolic isozyme I and II with su... Bioorg Med Chem. 2007 Mar 15;15(6):2298-311. DMRADWB RU https://pubmed.ncbi.nlm.nih.gov/17276072 DMQAVM4 DI DMQAVM4 DMQAVM4 DN 2-(4'-chloro-biphenyl-4-sulfonyl)-pentanoic acid DMQAVM4 MI TTLM12X DMQAVM4 MN Matrix metalloproteinase-2 (MMP-2) DMQAVM4 MT DTT DMQAVM4 MA Inhibitor DMQAVM4 RN Synthesis and SAR of alpha-sulfonylcarboxylic acids as potent matrix metalloproteinase inhibitors. Bioorg Med Chem Lett. 2006 Jun 15;16(12):3096-100. DMQAVM4 RU https://pubmed.ncbi.nlm.nih.gov/16632358 DMQAVM4 DI DMQAVM4 DMQAVM4 DN 2-(4'-chloro-biphenyl-4-sulfonyl)-pentanoic acid DMQAVM4 MI TT6X50U DMQAVM4 MN Matrix metalloproteinase-9 (MMP-9) DMQAVM4 MT DTT DMQAVM4 MA Inhibitor DMQAVM4 RN Synthesis and SAR of alpha-sulfonylcarboxylic acids as potent matrix metalloproteinase inhibitors. Bioorg Med Chem Lett. 2006 Jun 15;16(12):3096-100. DMQAVM4 RU https://pubmed.ncbi.nlm.nih.gov/16632358 DM6Z9U4 DI DM6Z9U4 DM6Z9U4 DN 2-(4-Chlorophenyl)-2H-indazole-7-carboxamide DM6Z9U4 MI TTVDSZ0 DM6Z9U4 MN Poly [ADP-ribose] polymerase 1 (PARP1) DM6Z9U4 MT DTT DM6Z9U4 MA Inhibitor DM6Z9U4 RN Discovery of 2-{4-[(3S)-piperidin-3-yl]phenyl}-2H-indazole-7-carboxamide (MK-4827): a novel oral poly(ADP-ribose)polymerase (PARP) inhibitor effica... J Med Chem. 2009 Nov 26;52(22):7170-85. DM6Z9U4 RU https://pubmed.ncbi.nlm.nih.gov/19873981 DMSB0JA DI DMSB0JA DMSB0JA DN 2-(4-Chloro-phenyl)-3H-imidazo[4,5-c]quinoline DMSB0JA MI TT1MPAY DMSB0JA MN GABA(A) receptor alpha-1 (GABRA1) DMSB0JA MT DTT DMSB0JA MA Inhibitor DMSB0JA RN Synthesis and structure--activity relationships of fused imidazopyridines: a new series of benzodiazepine receptor ligands. J Med Chem. 1996 Jul 5;39(14):2844-51. DMSB0JA RU https://pubmed.ncbi.nlm.nih.gov/8709114 DMSB0JA DI DMSB0JA DMSB0JA DN 2-(4-Chloro-phenyl)-3H-imidazo[4,5-c]quinoline DMSB0JA MI TTNJYV2 DMSB0JA MN Gamma-aminobutyric acid receptor (GAR) DMSB0JA MT DTT DMSB0JA MA Inhibitor DMSB0JA RN Synthesis and structure--activity relationships of fused imidazopyridines: a new series of benzodiazepine receptor ligands. J Med Chem. 1996 Jul 5;39(14):2844-51. DMSB0JA RU https://pubmed.ncbi.nlm.nih.gov/8709114 DMFQI4C DI DMFQI4C DMFQI4C DN 2-(4-chlorophenyl)-4,5-dihydro-1H-imidazole DMFQI4C MI TTGP7BY DMFQI4C MN Monoamine oxidase type B (MAO-B) DMFQI4C MT DTT DMFQI4C MA Inhibitor DMFQI4C RN Ultrasound promoted synthesis of 2-imidazolines in water: a greener approach toward monoamine oxidase inhibitors. Bioorg Med Chem Lett. 2009 Jan 15;19(2):546-9. DMFQI4C RU https://pubmed.ncbi.nlm.nih.gov/19064321 DMYGRS9 DI DMYGRS9 DMYGRS9 DN 2-(4-chlorophenyl)-5-phenyl-4-isoxazolin-3-one DMYGRS9 MI TT1MPAY DMYGRS9 MN GABA(A) receptor alpha-1 (GABRA1) DMYGRS9 MT DTT DMYGRS9 MA Inhibitor DMYGRS9 RN Synthesis, pharmacology, and structure-activity relationships of novel imidazolones and pyrrolones as modulators of GABAA receptors. J Med Chem. 2006 Mar 23;49(6):1855-66. DMYGRS9 RU https://pubmed.ncbi.nlm.nih.gov/16539371 DMYGRS9 DI DMYGRS9 DMYGRS9 DN 2-(4-chlorophenyl)-5-phenyl-4-isoxazolin-3-one DMYGRS9 MI TTZA1NY DMYGRS9 MN GABA(A) receptor beta-2 (GABRB2) DMYGRS9 MT DTT DMYGRS9 MA Inhibitor DMYGRS9 RN Synthesis, pharmacology, and structure-activity relationships of novel imidazolones and pyrrolones as modulators of GABAA receptors. J Med Chem. 2006 Mar 23;49(6):1855-66. DMYGRS9 RU https://pubmed.ncbi.nlm.nih.gov/16539371 DMYGRS9 DI DMYGRS9 DMYGRS9 DN 2-(4-chlorophenyl)-5-phenyl-4-isoxazolin-3-one DMYGRS9 MI TT06RH5 DMYGRS9 MN GABA(A) receptor gamma-2 (GABRG2) DMYGRS9 MT DTT DMYGRS9 MA Inhibitor DMYGRS9 RN Synthesis, pharmacology, and structure-activity relationships of novel imidazolones and pyrrolones as modulators of GABAA receptors. J Med Chem. 2006 Mar 23;49(6):1855-66. DMYGRS9 RU https://pubmed.ncbi.nlm.nih.gov/16539371 DMYGRS9 DI DMYGRS9 DMYGRS9 DN 2-(4-chlorophenyl)-5-phenyl-4-isoxazolin-3-one DMYGRS9 MI TTNJYV2 DMYGRS9 MN Gamma-aminobutyric acid receptor (GAR) DMYGRS9 MT DTT DMYGRS9 MA Inhibitor DMYGRS9 RN Synthesis, pharmacology, and structure-activity relationships of novel imidazolones and pyrrolones as modulators of GABAA receptors. J Med Chem. 2006 Mar 23;49(6):1855-66. DMYGRS9 RU https://pubmed.ncbi.nlm.nih.gov/16539371 DM9SGBO DI DM9SGBO DM9SGBO DN 2-(4-Chlorophenyl)-5-Quinoxalinecarboxamide DM9SGBO MI TTVDSZ0 DM9SGBO MN Poly [ADP-ribose] polymerase 1 (PARP1) DM9SGBO MT DTT DM9SGBO MA Inhibitor DM9SGBO RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DM9SGBO RU https://pubmed.ncbi.nlm.nih.gov/17139284 DM7EUOX DI DM7EUOX DM7EUOX DN 2-(4-chlorophenyl)-6-morpholino-4H-pyran-4-one DM7EUOX MI TTK3PY9 DM7EUOX MN DNA-dependent protein kinase catalytic (PRKDC) DM7EUOX MT DTT DM7EUOX MA Inhibitor DM7EUOX RN Pyranone, thiopyranone, and pyridone inhibitors of phosphatidylinositol 3-kinase related kinases. Structure-activity relationships for DNA-dependen... J Med Chem. 2007 Apr 19;50(8):1958-72. DM7EUOX RU https://pubmed.ncbi.nlm.nih.gov/17371003 DMAPWNR DI DMAPWNR DMAPWNR DN 2-(4-chlorophenyl)-6-phenyl-9H-purine DMAPWNR MI TTK25J1 DMAPWNR MN Adenosine A1 receptor (ADORA1) DMAPWNR MT DTT DMAPWNR MA Inhibitor DMAPWNR RN 2,6-disubstituted and 2,6,8-trisubstituted purines as adenosine receptor antagonists. J Med Chem. 2006 May 18;49(10):2861-7. DMAPWNR RU https://pubmed.ncbi.nlm.nih.gov/16686529 DMAPWNR DI DMAPWNR DMAPWNR DN 2-(4-chlorophenyl)-6-phenyl-9H-purine DMAPWNR MI TTM2AOE DMAPWNR MN Adenosine A2a receptor (ADORA2A) DMAPWNR MT DTT DMAPWNR MA Inhibitor DMAPWNR RN 2,6-disubstituted and 2,6,8-trisubstituted purines as adenosine receptor antagonists. J Med Chem. 2006 May 18;49(10):2861-7. DMAPWNR RU https://pubmed.ncbi.nlm.nih.gov/16686529 DMAPWNR DI DMAPWNR DMAPWNR DN 2-(4-chlorophenyl)-6-phenyl-9H-purine DMAPWNR MI TTJFY5U DMAPWNR MN Adenosine A3 receptor (ADORA3) DMAPWNR MT DTT DMAPWNR MA Inhibitor DMAPWNR RN 2,6-disubstituted and 2,6,8-trisubstituted purines as adenosine receptor antagonists. J Med Chem. 2006 May 18;49(10):2861-7. DMAPWNR RU https://pubmed.ncbi.nlm.nih.gov/16686529 DMJORCV DI DMJORCV DMJORCV DN 2-(4-chlorophenylsulfonyl)naphthalene-1,4-diol DMJORCV MI TTRVTMX DMJORCV MN Bacterial Beta-ketoacyl-ACP synthase III (Bact fabH) DMJORCV MT DTT DMJORCV MA Inhibitor DMJORCV RN Synthesis and biological evaluation of novel sulfonyl-naphthalene-1,4-diols as FabH inhibitors. Bioorg Med Chem Lett. 2008 Dec 15;18(24):6402-5. DMJORCV RU https://pubmed.ncbi.nlm.nih.gov/18996691 DM4XFJI DI DM4XFJI DM4XFJI DN 2-(4-cyano-2-cyclohexylphenoxy)acetic acid DM4XFJI MI TTQDMX5 DM4XFJI MN Prostaglandin D2 receptor 2 (PTGDR2) DM4XFJI MT DTT DM4XFJI MA Inhibitor DM4XFJI RN 2-Cycloalkyl phenoxyacetic acid CRTh2 receptor antagonists. Bioorg Med Chem Lett. 2007 Aug 1;17(15):4347-50. DM4XFJI RU https://pubmed.ncbi.nlm.nih.gov/17531480 DMOH46C DI DMOH46C DMOH46C DN 2-(4-cyclohexylthiosemicarbazono)methyl-phenol DMOH46C MI TTHM0R1 DMOH46C MN Steryl-sulfatase (STS) DMOH46C MT DTT DMOH46C MA Inhibitor DMOH46C RN Thiosemicarbazones of formyl benzoic acids as novel potent inhibitors of estrone sulfatase. J Med Chem. 2007 Jul 26;50(15):3661-6. DMOH46C RU https://pubmed.ncbi.nlm.nih.gov/17580843 DM6VQEO DI DM6VQEO DM6VQEO DN 2-(4-Cyclopentyl-piperazin-1-yl)-quinoline DM6VQEO MI TT9JNIC DM6VQEO MN Histamine H3 receptor (H3R) DM6VQEO MT DTT DM6VQEO MA Inhibitor DM6VQEO RN 2-(4-alkylpiperazin-1-yl)quinolines as a new class of imidazole-free histamine H3 receptor antagonists. J Med Chem. 2005 Jan 13;48(1):306-11. DM6VQEO RU https://pubmed.ncbi.nlm.nih.gov/15634025 DMPU90E DI DMPU90E DMPU90E DN 2-(4-Cyclopropyl-piperazin-1-yl)-quinoline DMPU90E MI TT9JNIC DMPU90E MN Histamine H3 receptor (H3R) DMPU90E MT DTT DMPU90E MA Inhibitor DMPU90E RN 2-(4-alkylpiperazin-1-yl)quinolines as a new class of imidazole-free histamine H3 receptor antagonists. J Med Chem. 2005 Jan 13;48(1):306-11. DMPU90E RU https://pubmed.ncbi.nlm.nih.gov/15634025 DM823CD DI DM823CD DM823CD DN 2-(4-Diethylamino-but-2-ynyl)-isoindole-1,3-dione DM823CD MI TTZ9SOR DM823CD MN Muscarinic acetylcholine receptor M1 (CHRM1) DM823CD MT DTT DM823CD MA Inhibitor DM823CD RN Design of dual acting anticonvulsant-antimuscarinic succinimide and hydantoin derivatives, Bioorg. Med. Chem. Lett. 7(8):979-984 (1997). DM823CD RU http://www.sciencedirect.com/science/article/pii/S0960894X97001431 DM823CD DI DM823CD DM823CD DN 2-(4-Diethylamino-but-2-ynyl)-isoindole-1,3-dione DM823CD MI TTYEG6Q DM823CD MN Muscarinic acetylcholine receptor M2 (CHRM2) DM823CD MT DTT DM823CD MA Inhibitor DM823CD RN Design of dual acting anticonvulsant-antimuscarinic succinimide and hydantoin derivatives, Bioorg. Med. Chem. Lett. 7(8):979-984 (1997). DM823CD RU http://www.sciencedirect.com/science/article/pii/S0960894X97001431 DMXH0FO DI DMXH0FO DMXH0FO DN 2-(4-Dipropylamino-cyclohexylidene)-malononitrile DMXH0FO MI TTEX248 DMXH0FO MN Dopamine D2 receptor (D2R) DMXH0FO MT DTT DMXH0FO MA Inhibitor DMXH0FO RN Conjugated enynes as nonaromatic catechol bioisosteres: synthesis, binding experiments, and computational studies of novel dopamine receptor agonis... J Med Chem. 2000 Feb 24;43(4):756-62. DMXH0FO RU https://pubmed.ncbi.nlm.nih.gov/10691700 DMXH0FO DI DMXH0FO DMXH0FO DN 2-(4-Dipropylamino-cyclohexylidene)-malononitrile DMXH0FO MI TT4C8EA DMXH0FO MN Dopamine D3 receptor (D3R) DMXH0FO MT DTT DMXH0FO MA Inhibitor DMXH0FO RN Conjugated enynes as nonaromatic catechol bioisosteres: synthesis, binding experiments, and computational studies of novel dopamine receptor agonis... J Med Chem. 2000 Feb 24;43(4):756-62. DMXH0FO RU https://pubmed.ncbi.nlm.nih.gov/10691700 DMTAVU5 DI DMTAVU5 DMTAVU5 DN 2-(4-ethylthiobenzimidazol-2-yl)quinoxaline DMTAVU5 MI TTK25J1 DMTAVU5 MN Adenosine A1 receptor (ADORA1) DMTAVU5 MT DTT DMTAVU5 MA Inhibitor DMTAVU5 RN 2-(Benzimidazol-2-yl)quinoxalines: a novel class of selective antagonists at human A(1) and A(3) adenosine receptors designed by 3D database search... J Med Chem. 2005 Dec 29;48(26):8253-60. DMTAVU5 RU https://pubmed.ncbi.nlm.nih.gov/16366607 DMTAVU5 DI DMTAVU5 DMTAVU5 DN 2-(4-ethylthiobenzimidazol-2-yl)quinoxaline DMTAVU5 MI TTM2AOE DMTAVU5 MN Adenosine A2a receptor (ADORA2A) DMTAVU5 MT DTT DMTAVU5 MA Inhibitor DMTAVU5 RN 2-(Benzimidazol-2-yl)quinoxalines: a novel class of selective antagonists at human A(1) and A(3) adenosine receptors designed by 3D database search... J Med Chem. 2005 Dec 29;48(26):8253-60. DMTAVU5 RU https://pubmed.ncbi.nlm.nih.gov/16366607 DMTAVU5 DI DMTAVU5 DMTAVU5 DN 2-(4-ethylthiobenzimidazol-2-yl)quinoxaline DMTAVU5 MI TTJFY5U DMTAVU5 MN Adenosine A3 receptor (ADORA3) DMTAVU5 MT DTT DMTAVU5 MA Inhibitor DMTAVU5 RN 2-(Benzimidazol-2-yl)quinoxalines: a novel class of selective antagonists at human A(1) and A(3) adenosine receptors designed by 3D database search... J Med Chem. 2005 Dec 29;48(26):8253-60. DMTAVU5 RU https://pubmed.ncbi.nlm.nih.gov/16366607 DMGLEX5 DI DMGLEX5 DMGLEX5 DN 2-(4-Fluoro-3-phenoxy-benzoylamino)-benzoic acid DMGLEX5 MI TTRVTMX DMGLEX5 MN Bacterial Beta-ketoacyl-ACP synthase III (Bact fabH) DMGLEX5 MT DTT DMGLEX5 MA Inhibitor DMGLEX5 RN Structure-based design, synthesis, and study of potent inhibitors of beta-ketoacyl-acyl carrier protein synthase III as potential antimicrobial age... J Med Chem. 2005 Mar 10;48(5):1596-609. DMGLEX5 RU https://pubmed.ncbi.nlm.nih.gov/15743201 DMZSHDR DI DMZSHDR DMZSHDR DN 2-(4-fluoro-benzyl)isoquinoline-1,3,4-trione DMZSHDR MI TTPF2QI DMZSHDR MN Caspase-3 (CASP3) DMZSHDR MT DTT DMZSHDR MA Inhibitor DMZSHDR RN Design, synthesis, and biological evaluation of isoquinoline-1,3,4-trione derivatives as potent caspase-3 inhibitors. J Med Chem. 2006 Mar 9;49(5):1613-23. DMZSHDR RU https://pubmed.ncbi.nlm.nih.gov/16509578 DMKFIEY DI DMKFIEY DMKFIEY DN 2-(4-Fluoro-indole-1-sulfonyl)-benzoic acid DMKFIEY MI TTHWMFZ DMKFIEY MN Fatty acid-binding protein 4 (FABP4) DMKFIEY MT DTT DMKFIEY MA Inhibitor DMKFIEY RN Discovery of inhibitors of human adipocyte fatty acid-binding protein, a potential type 2 diabetes target. Bioorg Med Chem Lett. 2004 Sep 6;14(17):4445-8. DMKFIEY RU https://pubmed.ncbi.nlm.nih.gov/15357969 DMECX8S DI DMECX8S DMECX8S DN 2-(4-fluorophenyl)-6-morpholino-4H-pyran-4-one DMECX8S MI TTK3PY9 DMECX8S MN DNA-dependent protein kinase catalytic (PRKDC) DMECX8S MT DTT DMECX8S MA Inhibitor DMECX8S RN Pyranone, thiopyranone, and pyridone inhibitors of phosphatidylinositol 3-kinase related kinases. Structure-activity relationships for DNA-dependen... J Med Chem. 2007 Apr 19;50(8):1958-72. DMECX8S RU https://pubmed.ncbi.nlm.nih.gov/17371003 DMZDGB3 DI DMZDGB3 DMZDGB3 DN 2-(4-fluorophenyl)-7-methoxy-4H-chromen-4-one DMZDGB3 MI TTGP7BY DMZDGB3 MN Monoamine oxidase type B (MAO-B) DMZDGB3 MT DTT DMZDGB3 MA Inhibitor DMZDGB3 RN A new series of flavones, thioflavones, and flavanones as selective monoamine oxidase-B inhibitors. Bioorg Med Chem. 2010 Feb;18(3):1273-9. DMZDGB3 RU https://pubmed.ncbi.nlm.nih.gov/20045650 DM0CDRP DI DM0CDRP DM0CDRP DN 2-(4-fluorophenylsulfonamido)-1-naphthoic acid DM0CDRP MI TTZL0OI DM0CDRP MN Methionine aminopeptidase 2 (METAP2) DM0CDRP MT DTT DM0CDRP MA Inhibitor DM0CDRP RN Development of sulfonamide compounds as potent methionine aminopeptidase type II inhibitors with antiproliferative properties. Bioorg Med Chem Lett. 2006 Jul 1;16(13):3574-7. DM0CDRP RU https://pubmed.ncbi.nlm.nih.gov/16632353 DM05HBC DI DM05HBC DM05HBC DN 2-(4-hexyl-2-methoxyphenoxy)pyrimidine DM05HBC MI TTVTX4N DM05HBC MN Bacterial Fatty acid synthetase I (Bact inhA) DM05HBC MT DTT DM05HBC MA Inhibitor DM05HBC RN Synthesis and in vitro antimycobacterial activity of B-ring modified diaryl ether InhA inhibitors. Bioorg Med Chem Lett. 2008 May 15;18(10):3029-33. DM05HBC RU https://pubmed.ncbi.nlm.nih.gov/18457948 DMCPN7V DI DMCPN7V DMCPN7V DN 2-(4-hydroxybenzylideneamino)ethanesulfonamide DMCPN7V MI TTANPDJ DMCPN7V MN Carbonic anhydrase II (CA-II) DMCPN7V MT DTT DMCPN7V MA Inhibitor DMCPN7V RN Carbonic anhydrase II-induced selection of inhibitors from a dynamic combinatorial library of Schiff's bases. Bioorg Med Chem Lett. 2009 Nov 1;19(21):6014-7. DMCPN7V RU https://pubmed.ncbi.nlm.nih.gov/19796939 DMM4S1R DI DMM4S1R DMM4S1R DN 2-(4-hydroxylphenyl)-3-(3,5-dihydroxylphenyl) propenoic acid (NNU-hdpa) DMM4S1R MI TT2J34L DMM4S1R MN Arachidonate 5-lipoxygenase (5-LOX) DMM4S1R MT DTT DMM4S1R MA Inhibitor DMM4S1R RN Anti-inflammatory effects and gastrointestinal safety of NNU-hdpa, a novel dual COX/5-LOX inhibitor. Eur J Pharmacol. 2009 Jun 2;611(1-3):100-6. DMM4S1R RU https://pubmed.ncbi.nlm.nih.gov/19345206 DMUGHF6 DI DMUGHF6 DMUGHF6 DN 2-(4-Hydroxy-naphthalen-1-yl)-benzooxazol-6-ol DMUGHF6 MI TTZAYWL DMUGHF6 MN Estrogen receptor (ESR) DMUGHF6 MT DTT DMUGHF6 MA Inhibitor DMUGHF6 RN Design and synthesis of aryl diphenolic azoles as potent and selective estrogen receptor-beta ligands. J Med Chem. 2004 Oct 7;47(21):5021-40. DMUGHF6 RU https://pubmed.ncbi.nlm.nih.gov/15456246 DMUGHF6 DI DMUGHF6 DMUGHF6 DN 2-(4-Hydroxy-naphthalen-1-yl)-benzooxazol-6-ol DMUGHF6 MI TTOM3J0 DMUGHF6 MN Estrogen receptor beta (ESR2) DMUGHF6 MT DTT DMUGHF6 MA Inhibitor DMUGHF6 RN Design and synthesis of aryl diphenolic azoles as potent and selective estrogen receptor-beta ligands. J Med Chem. 2004 Oct 7;47(21):5021-40. DMUGHF6 RU https://pubmed.ncbi.nlm.nih.gov/15456246 DM1C864 DI DM1C864 DM1C864 DN 2-(4-hydroxypent-1-yl)-N6-methoxyadenosine DM1C864 MI TTK25J1 DM1C864 MN Adenosine A1 receptor (ADORA1) DM1C864 MT DTT DM1C864 MA Inhibitor DM1C864 RN N6-methoxy-2-alkynyladenosine derivatives as highly potent and selective ligands at the human A3 adenosine receptor. J Med Chem. 2007 Mar 22;50(6):1222-30. DM1C864 RU https://pubmed.ncbi.nlm.nih.gov/17309246 DM1C864 DI DM1C864 DM1C864 DN 2-(4-hydroxypent-1-yl)-N6-methoxyadenosine DM1C864 MI TTM2AOE DM1C864 MN Adenosine A2a receptor (ADORA2A) DM1C864 MT DTT DM1C864 MA Inhibitor DM1C864 RN N6-methoxy-2-alkynyladenosine derivatives as highly potent and selective ligands at the human A3 adenosine receptor. J Med Chem. 2007 Mar 22;50(6):1222-30. DM1C864 RU https://pubmed.ncbi.nlm.nih.gov/17309246 DM1C864 DI DM1C864 DM1C864 DN 2-(4-hydroxypent-1-yl)-N6-methoxyadenosine DM1C864 MI TTJFY5U DM1C864 MN Adenosine A3 receptor (ADORA3) DM1C864 MT DTT DM1C864 MA Inhibitor DM1C864 RN N6-methoxy-2-alkynyladenosine derivatives as highly potent and selective ligands at the human A3 adenosine receptor. J Med Chem. 2007 Mar 22;50(6):1222-30. DM1C864 RU https://pubmed.ncbi.nlm.nih.gov/17309246 DMW6L38 DI DMW6L38 DMW6L38 DN 2-(4-hydroxyphenyl)-1,2'-spirobi[1H-indene]-5-ol DMW6L38 MI TTZAYWL DMW6L38 MN Estrogen receptor (ESR) DMW6L38 MT DTT DMW6L38 MA Inhibitor DMW6L38 RN 2-Phenylspiroindenes: a novel class of selective estrogen receptor modulators (SERMs). Bioorg Med Chem Lett. 2003 Feb 10;13(3):479-83. DMW6L38 RU https://pubmed.ncbi.nlm.nih.gov/12565955 DMW6L38 DI DMW6L38 DMW6L38 DN 2-(4-hydroxyphenyl)-1,2'-spirobi[1H-indene]-5-ol DMW6L38 MI TTOM3J0 DMW6L38 MN Estrogen receptor beta (ESR2) DMW6L38 MT DTT DMW6L38 MA Inhibitor DMW6L38 RN 2-Phenylspiroindenes: a novel class of selective estrogen receptor modulators (SERMs). Bioorg Med Chem Lett. 2003 Feb 10;13(3):479-83. DMW6L38 RU https://pubmed.ncbi.nlm.nih.gov/12565955 DMBIV8F DI DMBIV8F DMBIV8F DN 2-(4-Hydroxy-phenyl)-1-p-tolyl-3H-inden-5-ol DMBIV8F MI TTOM3J0 DMBIV8F MN Estrogen receptor beta (ESR2) DMBIV8F MT DTT DMBIV8F MA Inhibitor DMBIV8F RN Differential response of estrogen receptor subtypes to 1,3-diarylindene and 2,3-diarylindene ligands. J Med Chem. 2005 Sep 22;48(19):5989-6003. DMBIV8F RU https://pubmed.ncbi.nlm.nih.gov/16162002 DMNGW1A DI DMNGW1A DMNGW1A DN 2-(4-Hydroxy-phenyl)-3,3-diphenyl-acrylonitrile DMNGW1A MI TTFJ8Q1 DMNGW1A MN Protein kinase C alpha (PRKCA) DMNGW1A MT DTT DMNGW1A MA Inhibitor DMNGW1A RN Multivariate analysis by the minimum spanning tree method of the structural determinants of diphenylethylenes and triphenylacrylonitriles implicate... J Med Chem. 1992 Feb 7;35(3):573-83. DMNGW1A RU https://pubmed.ncbi.nlm.nih.gov/1738150 DMNGW1A DI DMNGW1A DMNGW1A DN 2-(4-Hydroxy-phenyl)-3,3-diphenyl-acrylonitrile DMNGW1A MI TTYPXQF DMNGW1A MN Protein kinase C beta (PRKCB) DMNGW1A MT DTT DMNGW1A MA Inhibitor DMNGW1A RN Multivariate analysis by the minimum spanning tree method of the structural determinants of diphenylethylenes and triphenylacrylonitriles implicate... J Med Chem. 1992 Feb 7;35(3):573-83. DMNGW1A RU https://pubmed.ncbi.nlm.nih.gov/1738150 DMNGW1A DI DMNGW1A DMNGW1A DN 2-(4-Hydroxy-phenyl)-3,3-diphenyl-acrylonitrile DMNGW1A MI TT9WJ8U DMNGW1A MN Protein kinase C delta (PRKCD) DMNGW1A MT DTT DMNGW1A MA Inhibitor DMNGW1A RN Multivariate analysis by the minimum spanning tree method of the structural determinants of diphenylethylenes and triphenylacrylonitriles implicate... J Med Chem. 1992 Feb 7;35(3):573-83. DMNGW1A RU https://pubmed.ncbi.nlm.nih.gov/1738150 DMNGW1A DI DMNGW1A DMNGW1A DN 2-(4-Hydroxy-phenyl)-3,3-diphenyl-acrylonitrile DMNGW1A MI TTBZ7OD DMNGW1A MN Protein kinase C epsilon (PRKCE) DMNGW1A MT DTT DMNGW1A MA Inhibitor DMNGW1A RN Multivariate analysis by the minimum spanning tree method of the structural determinants of diphenylethylenes and triphenylacrylonitriles implicate... J Med Chem. 1992 Feb 7;35(3):573-83. DMNGW1A RU https://pubmed.ncbi.nlm.nih.gov/1738150 DMNGW1A DI DMNGW1A DMNGW1A DN 2-(4-Hydroxy-phenyl)-3,3-diphenyl-acrylonitrile DMNGW1A MI TTRFOXJ DMNGW1A MN Protein kinase C gamma (PRKCG) DMNGW1A MT DTT DMNGW1A MA Inhibitor DMNGW1A RN Multivariate analysis by the minimum spanning tree method of the structural determinants of diphenylethylenes and triphenylacrylonitriles implicate... J Med Chem. 1992 Feb 7;35(3):573-83. DMNGW1A RU https://pubmed.ncbi.nlm.nih.gov/1738150 DMNGW1A DI DMNGW1A DMNGW1A DN 2-(4-Hydroxy-phenyl)-3,3-diphenyl-acrylonitrile DMNGW1A MI TT8QL1J DMNGW1A MN Protein kinase C theta (PRKCQ) DMNGW1A MT DTT DMNGW1A MA Inhibitor DMNGW1A RN Multivariate analysis by the minimum spanning tree method of the structural determinants of diphenylethylenes and triphenylacrylonitriles implicate... J Med Chem. 1992 Feb 7;35(3):573-83. DMNGW1A RU https://pubmed.ncbi.nlm.nih.gov/1738150 DMNGW1A DI DMNGW1A DMNGW1A DN 2-(4-Hydroxy-phenyl)-3,3-diphenyl-acrylonitrile DMNGW1A MI TTUWGRA DMNGW1A MN Protein kinase C zeta (PRKCZ) DMNGW1A MT DTT DMNGW1A MA Inhibitor DMNGW1A RN Multivariate analysis by the minimum spanning tree method of the structural determinants of diphenylethylenes and triphenylacrylonitriles implicate... J Med Chem. 1992 Feb 7;35(3):573-83. DMNGW1A RU https://pubmed.ncbi.nlm.nih.gov/1738150 DM4N0LB DI DM4N0LB DM4N0LB DN 2-(4-Hydroxy-phenyl)-4-methoxy-quinolin-6-ol DM4N0LB MI TTZAYWL DM4N0LB MN Estrogen receptor (ESR) DM4N0LB MT DTT DM4N0LB MA Inhibitor DM4N0LB RN ERbeta ligands. Part 4: Synthesis and structure-activity relationships of a series of 2-phenylquinoline derivatives. Bioorg Med Chem Lett. 2005 Oct 15;15(20):4520-5. DM4N0LB RU https://pubmed.ncbi.nlm.nih.gov/16098741 DM4N0LB DI DM4N0LB DM4N0LB DN 2-(4-Hydroxy-phenyl)-4-methoxy-quinolin-6-ol DM4N0LB MI TTOM3J0 DM4N0LB MN Estrogen receptor beta (ESR2) DM4N0LB MT DTT DM4N0LB MA Inhibitor DM4N0LB RN ERbeta ligands. Part 4: Synthesis and structure-activity relationships of a series of 2-phenylquinoline derivatives. Bioorg Med Chem Lett. 2005 Oct 15;15(20):4520-5. DM4N0LB RU https://pubmed.ncbi.nlm.nih.gov/16098741 DM81G2U DI DM81G2U DM81G2U DN 2-(4-Hydroxy-phenyl)-4-vinyl-quinolin-6-ol DM81G2U MI TTZAYWL DM81G2U MN Estrogen receptor (ESR) DM81G2U MT DTT DM81G2U MA Inhibitor DM81G2U RN ERbeta ligands. Part 4: Synthesis and structure-activity relationships of a series of 2-phenylquinoline derivatives. Bioorg Med Chem Lett. 2005 Oct 15;15(20):4520-5. DM81G2U RU https://pubmed.ncbi.nlm.nih.gov/16098741 DM81G2U DI DM81G2U DM81G2U DN 2-(4-Hydroxy-phenyl)-4-vinyl-quinolin-6-ol DM81G2U MI TTOM3J0 DM81G2U MN Estrogen receptor beta (ESR2) DM81G2U MT DTT DM81G2U MA Inhibitor DM81G2U RN ERbeta ligands. Part 4: Synthesis and structure-activity relationships of a series of 2-phenylquinoline derivatives. Bioorg Med Chem Lett. 2005 Oct 15;15(20):4520-5. DM81G2U RU https://pubmed.ncbi.nlm.nih.gov/16098741 DM81G2U DI DM81G2U DM81G2U DN 2-(4-Hydroxy-phenyl)-4-vinyl-quinolin-6-ol DM81G2U MI TTPNQAC DM81G2U MN Estrogen-related receptor-alpha (ESRRA) DM81G2U MT DTT DM81G2U MA Inhibitor DM81G2U RN ERbeta ligands. Part 6: 6H-Chromeno[4,3-b]quinolines as a new series of estrogen receptor beta-selective ligands. Bioorg Med Chem Lett. 2007 Jul 15;17(14):4053-6. DM81G2U RU https://pubmed.ncbi.nlm.nih.gov/17482813 DMFWOMY DI DMFWOMY DMFWOMY DN 2-(4-Hydroxy-phenyl)-7-isopropyl-benzooxazol-5-ol DMFWOMY MI TTZAYWL DMFWOMY MN Estrogen receptor (ESR) DMFWOMY MT DTT DMFWOMY MA Inhibitor DMFWOMY RN Design and synthesis of aryl diphenolic azoles as potent and selective estrogen receptor-beta ligands. J Med Chem. 2004 Oct 7;47(21):5021-40. DMFWOMY RU https://pubmed.ncbi.nlm.nih.gov/15456246 DMFWOMY DI DMFWOMY DMFWOMY DN 2-(4-Hydroxy-phenyl)-7-isopropyl-benzooxazol-5-ol DMFWOMY MI TTOM3J0 DMFWOMY MN Estrogen receptor beta (ESR2) DMFWOMY MT DTT DMFWOMY MA Inhibitor DMFWOMY RN Design and synthesis of aryl diphenolic azoles as potent and selective estrogen receptor-beta ligands. J Med Chem. 2004 Oct 7;47(21):5021-40. DMFWOMY RU https://pubmed.ncbi.nlm.nih.gov/15456246 DMY0I8P DI DMY0I8P DMY0I8P DN 2-(4-Hydroxy-phenyl)-7-methoxy-benzofuran-5-ol DMY0I8P MI TTZAYWL DMY0I8P MN Estrogen receptor (ESR) DMY0I8P MT DTT DMY0I8P MA Inhibitor DMY0I8P RN 7-Substituted 2-phenyl-benzofurans as ER beta selective ligands. Bioorg Med Chem Lett. 2004 Oct 4;14(19):4925-9. DMY0I8P RU https://pubmed.ncbi.nlm.nih.gov/15341953 DMY0I8P DI DMY0I8P DMY0I8P DN 2-(4-Hydroxy-phenyl)-7-methoxy-benzofuran-5-ol DMY0I8P MI TTOM3J0 DMY0I8P MN Estrogen receptor beta (ESR2) DMY0I8P MT DTT DMY0I8P MA Inhibitor DMY0I8P RN 7-Substituted 2-phenyl-benzofurans as ER beta selective ligands. Bioorg Med Chem Lett. 2004 Oct 4;14(19):4925-9. DMY0I8P RU https://pubmed.ncbi.nlm.nih.gov/15341953 DMCNITS DI DMCNITS DMCNITS DN 2-(4-Hydroxy-phenyl)-7-methoxy-benzooxazol-5-ol DMCNITS MI TTZAYWL DMCNITS MN Estrogen receptor (ESR) DMCNITS MT DTT DMCNITS MA Inhibitor DMCNITS RN Design and synthesis of aryl diphenolic azoles as potent and selective estrogen receptor-beta ligands. J Med Chem. 2004 Oct 7;47(21):5021-40. DMCNITS RU https://pubmed.ncbi.nlm.nih.gov/15456246 DMCNITS DI DMCNITS DMCNITS DN 2-(4-Hydroxy-phenyl)-7-methoxy-benzooxazol-5-ol DMCNITS MI TTOM3J0 DMCNITS MN Estrogen receptor beta (ESR2) DMCNITS MT DTT DMCNITS MA Inhibitor DMCNITS RN Design and synthesis of aryl diphenolic azoles as potent and selective estrogen receptor-beta ligands. J Med Chem. 2004 Oct 7;47(21):5021-40. DMCNITS RU https://pubmed.ncbi.nlm.nih.gov/15456246 DMT847Y DI DMT847Y DMT847Y DN 2-(4-hydroxyphenyl)-7-methoxychroman-4-one DMT847Y MI TTSZLWK DMT847Y MN Aromatase (CYP19A1) DMT847Y MT DTT DMT847Y MA Inhibitor DMT847Y RN New 7,8-benzoflavanones as potent aromatase inhibitors: synthesis and biological evaluation. Bioorg Med Chem. 2008 Feb 1;16(3):1474-80. DMT847Y RU https://pubmed.ncbi.nlm.nih.gov/18042388 DMQ2KPI DI DMQ2KPI DMQ2KPI DN 2-(4-Hydroxy-phenyl)-7-methyl-benzofuran-5-ol DMQ2KPI MI TTZAYWL DMQ2KPI MN Estrogen receptor (ESR) DMQ2KPI MT DTT DMQ2KPI MA Inhibitor DMQ2KPI RN 7-Substituted 2-phenyl-benzofurans as ER beta selective ligands. Bioorg Med Chem Lett. 2004 Oct 4;14(19):4925-9. DMQ2KPI RU https://pubmed.ncbi.nlm.nih.gov/15341953 DMQ2KPI DI DMQ2KPI DMQ2KPI DN 2-(4-Hydroxy-phenyl)-7-methyl-benzofuran-5-ol DMQ2KPI MI TTOM3J0 DMQ2KPI MN Estrogen receptor beta (ESR2) DMQ2KPI MT DTT DMQ2KPI MA Inhibitor DMQ2KPI RN 7-Substituted 2-phenyl-benzofurans as ER beta selective ligands. Bioorg Med Chem Lett. 2004 Oct 4;14(19):4925-9. DMQ2KPI RU https://pubmed.ncbi.nlm.nih.gov/15341953 DMUB7KH DI DMUB7KH DMUB7KH DN 2-(4-Hydroxy-phenyl)-7-phenyl-benzooxazol-5-ol DMUB7KH MI TTZAYWL DMUB7KH MN Estrogen receptor (ESR) DMUB7KH MT DTT DMUB7KH MA Inhibitor DMUB7KH RN Design and synthesis of aryl diphenolic azoles as potent and selective estrogen receptor-beta ligands. J Med Chem. 2004 Oct 7;47(21):5021-40. DMUB7KH RU https://pubmed.ncbi.nlm.nih.gov/15456246 DMUB7KH DI DMUB7KH DMUB7KH DN 2-(4-Hydroxy-phenyl)-7-phenyl-benzooxazol-5-ol DMUB7KH MI TTOM3J0 DMUB7KH MN Estrogen receptor beta (ESR2) DMUB7KH MT DTT DMUB7KH MA Inhibitor DMUB7KH RN Design and synthesis of aryl diphenolic azoles as potent and selective estrogen receptor-beta ligands. J Med Chem. 2004 Oct 7;47(21):5021-40. DMUB7KH RU https://pubmed.ncbi.nlm.nih.gov/15456246 DMND63Z DI DMND63Z DMND63Z DN 2-(4-Hydroxy-phenyl)-7-propenyl-benzooxazol-5-ol DMND63Z MI TTZAYWL DMND63Z MN Estrogen receptor (ESR) DMND63Z MT DTT DMND63Z MA Inhibitor DMND63Z RN Design and synthesis of aryl diphenolic azoles as potent and selective estrogen receptor-beta ligands. J Med Chem. 2004 Oct 7;47(21):5021-40. DMND63Z RU https://pubmed.ncbi.nlm.nih.gov/15456246 DMND63Z DI DMND63Z DMND63Z DN 2-(4-Hydroxy-phenyl)-7-propenyl-benzooxazol-5-ol DMND63Z MI TTOM3J0 DMND63Z MN Estrogen receptor beta (ESR2) DMND63Z MT DTT DMND63Z MA Inhibitor DMND63Z RN Design and synthesis of aryl diphenolic azoles as potent and selective estrogen receptor-beta ligands. J Med Chem. 2004 Oct 7;47(21):5021-40. DMND63Z RU https://pubmed.ncbi.nlm.nih.gov/15456246 DMONT2D DI DMONT2D DMONT2D DN 2-(4-Hydroxy-phenyl)-7-propyl-benzooxazol-5-ol DMONT2D MI TTZAYWL DMONT2D MN Estrogen receptor (ESR) DMONT2D MT DTT DMONT2D MA Inhibitor DMONT2D RN Design and synthesis of aryl diphenolic azoles as potent and selective estrogen receptor-beta ligands. J Med Chem. 2004 Oct 7;47(21):5021-40. DMONT2D RU https://pubmed.ncbi.nlm.nih.gov/15456246 DMONT2D DI DMONT2D DMONT2D DN 2-(4-Hydroxy-phenyl)-7-propyl-benzooxazol-5-ol DMONT2D MI TTOM3J0 DMONT2D MN Estrogen receptor beta (ESR2) DMONT2D MT DTT DMONT2D MA Inhibitor DMONT2D RN Design and synthesis of aryl diphenolic azoles as potent and selective estrogen receptor-beta ligands. J Med Chem. 2004 Oct 7;47(21):5021-40. DMONT2D RU https://pubmed.ncbi.nlm.nih.gov/15456246 DM2F6U3 DI DM2F6U3 DM2F6U3 DN 2-(4-Hydroxy-phenyl)-7-vinyl-benzooxazol-5-ol DM2F6U3 MI TTZAYWL DM2F6U3 MN Estrogen receptor (ESR) DM2F6U3 MT DTT DM2F6U3 MA Inhibitor DM2F6U3 RN Design and synthesis of aryl diphenolic azoles as potent and selective estrogen receptor-beta ligands. J Med Chem. 2004 Oct 7;47(21):5021-40. DM2F6U3 RU https://pubmed.ncbi.nlm.nih.gov/15456246 DM2F6U3 DI DM2F6U3 DM2F6U3 DN 2-(4-Hydroxy-phenyl)-7-vinyl-benzooxazol-5-ol DM2F6U3 MI TTOM3J0 DM2F6U3 MN Estrogen receptor beta (ESR2) DM2F6U3 MT DTT DM2F6U3 MA Inhibitor DM2F6U3 RN Design and synthesis of aryl diphenolic azoles as potent and selective estrogen receptor-beta ligands. J Med Chem. 2004 Oct 7;47(21):5021-40. DM2F6U3 RU https://pubmed.ncbi.nlm.nih.gov/15456246 DMVHQM9 DI DMVHQM9 DMVHQM9 DN 2-(4-Hydroxy-phenyl)-8-methyl-3H-quinazolin-4-one DMVHQM9 MI TTVDSZ0 DMVHQM9 MN Poly [ADP-ribose] polymerase 1 (PARP1) DMVHQM9 MT DTT DMVHQM9 MA Inhibitor DMVHQM9 RN Resistance-modifying agents. 5. Synthesis and biological properties of quinazolinone inhibitors of the DNA repair enzyme poly(ADP-ribose) polymeras... J Med Chem. 1998 Dec 17;41(26):5247-56. DMVHQM9 RU https://pubmed.ncbi.nlm.nih.gov/9857092 DMN6S3F DI DMN6S3F DMN6S3F DN 2-(4-HYDROXY-PHENYL)BENZOFURAN-5-OL DMN6S3F MI TTZAYWL DMN6S3F MN Estrogen receptor (ESR) DMN6S3F MT DTT DMN6S3F MA Inhibitor DMN6S3F RN Design and synthesis of aryl diphenolic azoles as potent and selective estrogen receptor-beta ligands. J Med Chem. 2004 Oct 7;47(21):5021-40. DMN6S3F RU https://pubmed.ncbi.nlm.nih.gov/15456246 DMN6S3F DI DMN6S3F DMN6S3F DN 2-(4-HYDROXY-PHENYL)BENZOFURAN-5-OL DMN6S3F MI TTOM3J0 DMN6S3F MN Estrogen receptor beta (ESR2) DMN6S3F MT DTT DMN6S3F MA Inhibitor DMN6S3F RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DMN6S3F RU https://pubmed.ncbi.nlm.nih.gov/10592235 DMMUNA7 DI DMMUNA7 DMMUNA7 DN 2-(4-Hydroxy-phenyl)-benzooxazol-5-ol DMMUNA7 MI TTZAYWL DMMUNA7 MN Estrogen receptor (ESR) DMMUNA7 MT DTT DMMUNA7 MA Inhibitor DMMUNA7 RN Design and synthesis of aryl diphenolic azoles as potent and selective estrogen receptor-beta ligands. J Med Chem. 2004 Oct 7;47(21):5021-40. DMMUNA7 RU https://pubmed.ncbi.nlm.nih.gov/15456246 DMMUNA7 DI DMMUNA7 DMMUNA7 DN 2-(4-Hydroxy-phenyl)-benzooxazol-5-ol DMMUNA7 MI TTOM3J0 DMMUNA7 MN Estrogen receptor beta (ESR2) DMMUNA7 MT DTT DMMUNA7 MA Inhibitor DMMUNA7 RN Design and synthesis of aryl diphenolic azoles as potent and selective estrogen receptor-beta ligands. J Med Chem. 2004 Oct 7;47(21):5021-40. DMMUNA7 RU https://pubmed.ncbi.nlm.nih.gov/15456246 DM31MY0 DI DM31MY0 DM31MY0 DN 2-(4-Hydroxy-phenyl)-benzooxazol-6-ol DM31MY0 MI TTZAYWL DM31MY0 MN Estrogen receptor (ESR) DM31MY0 MT DTT DM31MY0 MA Inhibitor DM31MY0 RN Design and synthesis of aryl diphenolic azoles as potent and selective estrogen receptor-beta ligands. J Med Chem. 2004 Oct 7;47(21):5021-40. DM31MY0 RU https://pubmed.ncbi.nlm.nih.gov/15456246 DM31MY0 DI DM31MY0 DM31MY0 DN 2-(4-Hydroxy-phenyl)-benzooxazol-6-ol DM31MY0 MI TTOM3J0 DM31MY0 MN Estrogen receptor beta (ESR2) DM31MY0 MT DTT DM31MY0 MA Inhibitor DM31MY0 RN Design and synthesis of aryl diphenolic azoles as potent and selective estrogen receptor-beta ligands. J Med Chem. 2004 Oct 7;47(21):5021-40. DM31MY0 RU https://pubmed.ncbi.nlm.nih.gov/15456246 DMCWFUZ DI DMCWFUZ DMCWFUZ DN 2-(4-Hydroxy-phenyl)-quinolin-6-ol DMCWFUZ MI TTZAYWL DMCWFUZ MN Estrogen receptor (ESR) DMCWFUZ MT DTT DMCWFUZ MA Inhibitor DMCWFUZ RN ERbeta ligands. Part 4: Synthesis and structure-activity relationships of a series of 2-phenylquinoline derivatives. Bioorg Med Chem Lett. 2005 Oct 15;15(20):4520-5. DMCWFUZ RU https://pubmed.ncbi.nlm.nih.gov/16098741 DMCWFUZ DI DMCWFUZ DMCWFUZ DN 2-(4-Hydroxy-phenyl)-quinolin-6-ol DMCWFUZ MI TTOM3J0 DMCWFUZ MN Estrogen receptor beta (ESR2) DMCWFUZ MT DTT DMCWFUZ MA Inhibitor DMCWFUZ RN ERbeta ligands. Part 4: Synthesis and structure-activity relationships of a series of 2-phenylquinoline derivatives. Bioorg Med Chem Lett. 2005 Oct 15;15(20):4520-5. DMCWFUZ RU https://pubmed.ncbi.nlm.nih.gov/16098741 DM8GBH4 DI DM8GBH4 DM8GBH4 DN 2-(4-hydroxystyryl)quinolin-8-ol DM8GBH4 MI TT6804T DM8GBH4 MN MIF messenger RNA (MIF mRNA) DM8GBH4 MT DTT DM8GBH4 MA Inhibitor DM8GBH4 RN Discovery of human macrophage migration inhibitory factor (MIF)-CD74 antagonists via virtual screening. J Med Chem. 2009 Jan 22;52(2):416-24. DM8GBH4 RU https://pubmed.ncbi.nlm.nih.gov/19090668 DMUIVS9 DI DMUIVS9 DMUIVS9 DN 2-(4-Imidazol-1-yl-phenoxymethyl)-pyridine DMUIVS9 MI TTXV4FI DMUIVS9 MN Albendazole monooxygenase (CYP3A4) DMUIVS9 MT DTT DMUIVS9 MA Inhibitor DMUIVS9 RN Imidazole derivatives as new potent and selective 20-HETE synthase inhibitors. Bioorg Med Chem Lett. 2004 Jan 19;14(2):333-6. DMUIVS9 RU https://pubmed.ncbi.nlm.nih.gov/14698153 DMUIVS9 DI DMUIVS9 DMUIVS9 DN 2-(4-Imidazol-1-yl-phenoxymethyl)-pyridine DMUIVS9 MI TTVG215 DMUIVS9 MN Debrisoquine 4-hydroxylase (CYP2D6) DMUIVS9 MT DTT DMUIVS9 MA Inhibitor DMUIVS9 RN Imidazole derivatives as new potent and selective 20-HETE synthase inhibitors. Bioorg Med Chem Lett. 2004 Jan 19;14(2):333-6. DMUIVS9 RU https://pubmed.ncbi.nlm.nih.gov/14698153 DMSH4WP DI DMSH4WP DMSH4WP DN 2-(4-Isopropyl-piperazin-1-yl)-quinoline DMSH4WP MI TT9JNIC DMSH4WP MN Histamine H3 receptor (H3R) DMSH4WP MT DTT DMSH4WP MA Inhibitor DMSH4WP RN 2-(4-alkylpiperazin-1-yl)quinolines as a new class of imidazole-free histamine H3 receptor antagonists. J Med Chem. 2005 Jan 13;48(1):306-11. DMSH4WP RU https://pubmed.ncbi.nlm.nih.gov/15634025 DMXPJF3 DI DMXPJF3 DMXPJF3 DN 2-(4-Mercapto-butyl)-pentanedioic acid DMXPJF3 MI TT9G4N0 DMXPJF3 MN Glutamate carboxypeptidase II (GCPII) DMXPJF3 MT DTT DMXPJF3 MA Inhibitor DMXPJF3 RN Synthesis and biological evaluation of thiol-based inhibitors of glutamate carboxypeptidase II: discovery of an orally active GCP II inhibitor. J Med Chem. 2003 May 8;46(10):1989-96. DMXPJF3 RU https://pubmed.ncbi.nlm.nih.gov/12723961 DMHAE31 DI DMHAE31 DMHAE31 DN 2-(4-methoxy-benzyl)isoquinoline-1,3,4-trione DMHAE31 MI TTPF2QI DMHAE31 MN Caspase-3 (CASP3) DMHAE31 MT DTT DMHAE31 MA Inhibitor DMHAE31 RN Design, synthesis, and biological evaluation of isoquinoline-1,3,4-trione derivatives as potent caspase-3 inhibitors. J Med Chem. 2006 Mar 9;49(5):1613-23. DMHAE31 RU https://pubmed.ncbi.nlm.nih.gov/16509578 DMZNPMQ DI DMZNPMQ DMZNPMQ DN 2-(4-methoxybenzylthio)-6-methylpyrimidin-4-ol DMZNPMQ MI TTHY57M DMZNPMQ MN Matrix metalloproteinase-13 (MMP-13) DMZNPMQ MT DTT DMZNPMQ MA Inhibitor DMZNPMQ RN Ranking the selectivity of PubChem screening hits by activity-based protein profiling: MMP13 as a case study. Bioorg Med Chem. 2009 Feb 1;17(3):1101-8. DMZNPMQ RU https://pubmed.ncbi.nlm.nih.gov/18364257 DMTEQU8 DI DMTEQU8 DMTEQU8 DN 2-(4-Methoxy-phenyl)-1H-indole-3-carbaldehyde DMTEQU8 MI TTML2WA DMTEQU8 MN Tubulin (TUB) DMTEQU8 MT DTT DMTEQU8 MA Inhibitor DMTEQU8 RN Methoxy-substituted 3-formyl-2-phenylindoles inhibit tubulin polymerization. J Med Chem. 1998 Dec 3;41(25):4965-72. DMTEQU8 RU https://pubmed.ncbi.nlm.nih.gov/9836614 DMTEQU8 DI DMTEQU8 DMTEQU8 DN 2-(4-Methoxy-phenyl)-1H-indole-3-carbaldehyde DMTEQU8 MI TTYFKSZ DMTEQU8 MN Tubulin beta (TUBB) DMTEQU8 MT DTT DMTEQU8 MA Inhibitor DMTEQU8 RN Methoxy-substituted 3-formyl-2-phenylindoles inhibit tubulin polymerization. J Med Chem. 1998 Dec 3;41(25):4965-72. DMTEQU8 RU https://pubmed.ncbi.nlm.nih.gov/9836614 DM0KUMX DI DM0KUMX DM0KUMX DN 2-(4-methoxyphenyl)-4,5-dihydro-1H-imidazole DM0KUMX MI TT3WG5C DM0KUMX MN Monoamine oxidase type A (MAO-A) DM0KUMX MT DTT DM0KUMX MA Inhibitor DM0KUMX RN Ultrasound promoted synthesis of 2-imidazolines in water: a greener approach toward monoamine oxidase inhibitors. Bioorg Med Chem Lett. 2009 Jan 15;19(2):546-9. DM0KUMX RU https://pubmed.ncbi.nlm.nih.gov/19064321 DMIDXTR DI DMIDXTR DMIDXTR DN 2-(4-methoxyphenyl)-4H-chromene-4-thione DMIDXTR MI TTGP7BY DMIDXTR MN Monoamine oxidase type B (MAO-B) DMIDXTR MT DTT DMIDXTR MA Inhibitor DMIDXTR RN A new series of flavones, thioflavones, and flavanones as selective monoamine oxidase-B inhibitors. Bioorg Med Chem. 2010 Feb;18(3):1273-9. DMIDXTR RU https://pubmed.ncbi.nlm.nih.gov/20045650 DMZ9A6U DI DMZ9A6U DMZ9A6U DN 2-(4-Methoxy-phenyl)-5-phenyl-thiazol-4-ol DMZ9A6U MI TT2J34L DMZ9A6U MN Arachidonate 5-lipoxygenase (5-LOX) DMZ9A6U MT DTT DMZ9A6U MA Inhibitor DMZ9A6U RN 4-hydroxythiazole inhibitors of 5-lipoxygenase. J Med Chem. 1991 Jul;34(7):2158-65. DMZ9A6U RU https://pubmed.ncbi.nlm.nih.gov/2066989 DMVQU1M DI DMVQU1M DMVQU1M DN 2-(4-methoxyphenyl)-6-morpholino-4H-pyran-4-one DMVQU1M MI TTK3PY9 DMVQU1M MN DNA-dependent protein kinase catalytic (PRKDC) DMVQU1M MT DTT DMVQU1M MA Inhibitor DMVQU1M RN Pyranone, thiopyranone, and pyridone inhibitors of phosphatidylinositol 3-kinase related kinases. Structure-activity relationships for DNA-dependen... J Med Chem. 2007 Apr 19;50(8):1958-72. DMVQU1M RU https://pubmed.ncbi.nlm.nih.gov/17371003 DMXTHOV DI DMXTHOV DMXTHOV DN 2-(4-methoxyphenyl)-6-phenyl-9H-purine DMXTHOV MI TTK25J1 DMXTHOV MN Adenosine A1 receptor (ADORA1) DMXTHOV MT DTT DMXTHOV MA Inhibitor DMXTHOV RN 2,6-disubstituted and 2,6,8-trisubstituted purines as adenosine receptor antagonists. J Med Chem. 2006 May 18;49(10):2861-7. DMXTHOV RU https://pubmed.ncbi.nlm.nih.gov/16686529 DMXTHOV DI DMXTHOV DMXTHOV DN 2-(4-methoxyphenyl)-6-phenyl-9H-purine DMXTHOV MI TTJFY5U DMXTHOV MN Adenosine A3 receptor (ADORA3) DMXTHOV MT DTT DMXTHOV MA Inhibitor DMXTHOV RN 2,6-disubstituted and 2,6,8-trisubstituted purines as adenosine receptor antagonists. J Med Chem. 2006 May 18;49(10):2861-7. DMXTHOV RU https://pubmed.ncbi.nlm.nih.gov/16686529 DMS572H DI DMS572H DMS572H DN 2-(4-Methoxy-phenyl)-8-methyl-3H-quinazolin-4-one DMS572H MI TTVDSZ0 DMS572H MN Poly [ADP-ribose] polymerase 1 (PARP1) DMS572H MT DTT DMS572H MA Inhibitor DMS572H RN Resistance-modifying agents. 5. Synthesis and biological properties of quinazolinone inhibitors of the DNA repair enzyme poly(ADP-ribose) polymeras... J Med Chem. 1998 Dec 17;41(26):5247-56. DMS572H RU https://pubmed.ncbi.nlm.nih.gov/9857092 DM1N08O DI DM1N08O DM1N08O DN 2-(4-methoxyphenyl)-N-(thiazol-2-yl)acetamide DM1N08O MI TTSJ6Q4 DM1N08O MN LOX-5 messenger RNA (ALOX5 mRNA) DM1N08O MT DTT DM1N08O MA Inhibitor DM1N08O RN Identification of natural-product-derived inhibitors of 5-lipoxygenase activity by ligand-based virtual screening. J Med Chem. 2007 May 31;50(11):2640-6. DM1N08O RU https://pubmed.ncbi.nlm.nih.gov/17461565 DMBRETS DI DMBRETS DMBRETS DN 2-(4-methoxyphenyl)quinoline-8-carboxamide DMBRETS MI TTVDSZ0 DMBRETS MN Poly [ADP-ribose] polymerase 1 (PARP1) DMBRETS MT DTT DMBRETS MA Inhibitor DMBRETS RN Design, synthesis, and evaluation in vitro of quinoline-8-carboxamides, a new class of poly(adenosine-diphosphate-ribose)polymerase-1 (PARP-1) inhi... J Med Chem. 2009 Feb 12;52(3):868-77. DMBRETS RU https://pubmed.ncbi.nlm.nih.gov/19117416 DMDXIN1 DI DMDXIN1 DMDXIN1 DN 2-(4-methyl-1H-benzo[d]imidazol-2-yl)quinoxaline DMDXIN1 MI TTK25J1 DMDXIN1 MN Adenosine A1 receptor (ADORA1) DMDXIN1 MT DTT DMDXIN1 MA Inhibitor DMDXIN1 RN Derivatives of 4-amino-6-hydroxy-2-mercaptopyrimidine as novel, potent, and selective A3 adenosine receptor antagonists. J Med Chem. 2008 Mar 27;51(6):1764-70. DMDXIN1 RU https://pubmed.ncbi.nlm.nih.gov/18269230 DMDXIN1 DI DMDXIN1 DMDXIN1 DN 2-(4-methyl-1H-benzo[d]imidazol-2-yl)quinoxaline DMDXIN1 MI TTM2AOE DMDXIN1 MN Adenosine A2a receptor (ADORA2A) DMDXIN1 MT DTT DMDXIN1 MA Inhibitor DMDXIN1 RN Derivatives of 4-amino-6-hydroxy-2-mercaptopyrimidine as novel, potent, and selective A3 adenosine receptor antagonists. J Med Chem. 2008 Mar 27;51(6):1764-70. DMDXIN1 RU https://pubmed.ncbi.nlm.nih.gov/18269230 DMDXIN1 DI DMDXIN1 DMDXIN1 DN 2-(4-methyl-1H-benzo[d]imidazol-2-yl)quinoxaline DMDXIN1 MI TTJFY5U DMDXIN1 MN Adenosine A3 receptor (ADORA3) DMDXIN1 MT DTT DMDXIN1 MA Inhibitor DMDXIN1 RN Derivatives of 4-amino-6-hydroxy-2-mercaptopyrimidine as novel, potent, and selective A3 adenosine receptor antagonists. J Med Chem. 2008 Mar 27;51(6):1764-70. DMDXIN1 RU https://pubmed.ncbi.nlm.nih.gov/18269230 DM943YL DI DM943YL DM943YL DN 2-(4-Methyl-indole-1-sulfonyl)-benzoic acid DM943YL MI TTHWMFZ DM943YL MN Fatty acid-binding protein 4 (FABP4) DM943YL MT DTT DM943YL MA Inhibitor DM943YL RN Discovery of inhibitors of human adipocyte fatty acid-binding protein, a potential type 2 diabetes target. Bioorg Med Chem Lett. 2004 Sep 6;14(17):4445-8. DM943YL RU https://pubmed.ncbi.nlm.nih.gov/15357969 DMDHFU9 DI DMDHFU9 DMDHFU9 DN 2-(4-Methyl-piperazin-1-yl)-4-phenyl-pyrimidine DMDHFU9 MI TTSQIFT DMDHFU9 MN 5-HT 1A receptor (HTR1A) DMDHFU9 MT DTT DMDHFU9 MA Inhibitor DMDHFU9 RN 4-(3-furyl)-2-(4-methylpiperazino)pyrimidines: Potent 5-HT2A receptor antagonists, Bioorg. Med. Chem. Lett. 7(13):1635-1638 (1997). DMDHFU9 RU http://www.sciencedirect.com/science/article/pii/S0960894X97002916 DMDHFU9 DI DMDHFU9 DMDHFU9 DN 2-(4-Methyl-piperazin-1-yl)-4-phenyl-pyrimidine DMDHFU9 MI TTJQOD7 DMDHFU9 MN 5-HT 2A receptor (HTR2A) DMDHFU9 MT DTT DMDHFU9 MA Inhibitor DMDHFU9 RN 4-(3-furyl)-2-(4-methylpiperazino)pyrimidines: Potent 5-HT2A receptor antagonists, Bioorg. Med. Chem. Lett. 7(13):1635-1638 (1997). DMDHFU9 RU http://www.sciencedirect.com/science/article/pii/S0960894X97002916 DMB8OY6 DI DMB8OY6 DMB8OY6 DN 2-(4-Methyl-piperazin-1-yl)-quinoline DMB8OY6 MI TTPC4TU DMB8OY6 MN 5-HT 3A receptor (HTR3A) DMB8OY6 MT DTT DMB8OY6 MA Inhibitor DMB8OY6 RN Novel potent and selective central 5-HT3 receptor ligands provided with different intrinsic efficacy. 2. Molecular basis of the intrinsic efficacy ... J Med Chem. 1999 May 6;42(9):1556-75. DMB8OY6 RU https://pubmed.ncbi.nlm.nih.gov/10229626 DMB8OY6 DI DMB8OY6 DMB8OY6 DN 2-(4-Methyl-piperazin-1-yl)-quinoline DMB8OY6 MI TTR6K75 DMB8OY6 MN 5-HT 3B receptor (HTR3B) DMB8OY6 MT DTT DMB8OY6 MA Inhibitor DMB8OY6 RN Novel potent and selective central 5-HT3 receptor ligands provided with different intrinsic efficacy. 2. Molecular basis of the intrinsic efficacy ... J Med Chem. 1999 May 6;42(9):1556-75. DMB8OY6 RU https://pubmed.ncbi.nlm.nih.gov/10229626 DMB8OY6 DI DMB8OY6 DMB8OY6 DN 2-(4-Methyl-piperazin-1-yl)-quinoline DMB8OY6 MI TT9JNIC DMB8OY6 MN Histamine H3 receptor (H3R) DMB8OY6 MT DTT DMB8OY6 MA Inhibitor DMB8OY6 RN 2-(4-alkylpiperazin-1-yl)quinolines as a new class of imidazole-free histamine H3 receptor antagonists. J Med Chem. 2005 Jan 13;48(1):306-11. DMB8OY6 RU https://pubmed.ncbi.nlm.nih.gov/15634025 DMBJICP DI DMBJICP DMBJICP DN 2-(4-nitro-1H-benzo[d]imidazol-2-yl)quinoxaline DMBJICP MI TTJFY5U DMBJICP MN Adenosine A3 receptor (ADORA3) DMBJICP MT DTT DMBJICP MA Inhibitor DMBJICP RN 2-(Benzimidazol-2-yl)quinoxalines: a novel class of selective antagonists at human A(1) and A(3) adenosine receptors designed by 3D database search... J Med Chem. 2005 Dec 29;48(26):8253-60. DMBJICP RU https://pubmed.ncbi.nlm.nih.gov/16366607 DMX8U32 DI DMX8U32 DMX8U32 DN 2-(4-nitrophenyl)-5-(4-methoxyphenyl)thiophene DMX8U32 MI TTE4KHA DMX8U32 MN Amyloid beta A4 protein (APP) DMX8U32 MT DTT DMX8U32 MA Inhibitor DMX8U32 RN Design, synthesis, and structure-activity relationship of novel thiophene derivatives for beta-amyloid plaque imaging. Bioorg Med Chem Lett. 2006 Mar 1;16(5):1350-2. DMX8U32 RU https://pubmed.ncbi.nlm.nih.gov/16325402 DMR54SW DI DMR54SW DMR54SW DN 2-(4-pentylphenyl)-N-(pyridin-3-yl)acetamide DMR54SW MI TTMI6F5 DMR54SW MN Transient receptor potential cation channel V1 (TRPV1) DMR54SW MT DTT DMR54SW MA Inhibitor DMR54SW RN N-pyridin-3-yl- and N-quinolin-3-yl-benzamides: modulators of human vanilloid receptor 1 (TRPV1). Bioorg Med Chem Lett. 2008 Apr 15;18(8):2730-4. DMR54SW RU https://pubmed.ncbi.nlm.nih.gov/18359227 DM65IF1 DI DM65IF1 DM65IF1 DN 2-(4-Phenoxy-benzyl)-1H-benzoimidazole DM65IF1 MI TTLD29N DM65IF1 MN Glutamate receptor ionotropic NMDA 1 (NMDAR1) DM65IF1 MT DTT DM65IF1 MA Inhibitor DM65IF1 RN NR2B-selective N-methyl-D-aspartate antagonists: synthesis and evaluation of 5-substituted benzimidazoles. J Med Chem. 2004 Apr 8;47(8):2089-96. DM65IF1 RU https://pubmed.ncbi.nlm.nih.gov/15056006 DM65IF1 DI DM65IF1 DM65IF1 DN 2-(4-Phenoxy-benzyl)-1H-benzoimidazole DM65IF1 MI TTN9D8E DM65IF1 MN Glutamate receptor ionotropic NMDA 2B (NMDAR2B) DM65IF1 MT DTT DM65IF1 MA Inhibitor DM65IF1 RN NR2B-selective N-methyl-D-aspartate antagonists: synthesis and evaluation of 5-substituted benzimidazoles. J Med Chem. 2004 Apr 8;47(8):2089-96. DM65IF1 RU https://pubmed.ncbi.nlm.nih.gov/15056006 DM3HANW DI DM3HANW DM3HANW DN 2-(4-Phenoxy-benzyl)-3H-benzoimidazol-4-ol DM3HANW MI TTLD29N DM3HANW MN Glutamate receptor ionotropic NMDA 1 (NMDAR1) DM3HANW MT DTT DM3HANW MA Inhibitor DM3HANW RN NR2B-selective N-methyl-D-aspartate antagonists: synthesis and evaluation of 5-substituted benzimidazoles. J Med Chem. 2004 Apr 8;47(8):2089-96. DM3HANW RU https://pubmed.ncbi.nlm.nih.gov/15056006 DM3HANW DI DM3HANW DM3HANW DN 2-(4-Phenoxy-benzyl)-3H-benzoimidazol-4-ol DM3HANW MI TTN9D8E DM3HANW MN Glutamate receptor ionotropic NMDA 2B (NMDAR2B) DM3HANW MT DTT DM3HANW MA Inhibitor DM3HANW RN NR2B-selective N-methyl-D-aspartate antagonists: synthesis and evaluation of 5-substituted benzimidazoles. J Med Chem. 2004 Apr 8;47(8):2089-96. DM3HANW RU https://pubmed.ncbi.nlm.nih.gov/15056006 DMFO19B DI DMFO19B DMFO19B DN 2-(4-Phenoxy-benzyl)-3H-benzoimidazol-5-ol DMFO19B MI TTLD29N DMFO19B MN Glutamate receptor ionotropic NMDA 1 (NMDAR1) DMFO19B MT DTT DMFO19B MA Inhibitor DMFO19B RN NR2B-selective N-methyl-D-aspartate antagonists: synthesis and evaluation of 5-substituted benzimidazoles. J Med Chem. 2004 Apr 8;47(8):2089-96. DMFO19B RU https://pubmed.ncbi.nlm.nih.gov/15056006 DMFO19B DI DMFO19B DMFO19B DN 2-(4-Phenoxy-benzyl)-3H-benzoimidazol-5-ol DMFO19B MI TTN9D8E DMFO19B MN Glutamate receptor ionotropic NMDA 2B (NMDAR2B) DMFO19B MT DTT DMFO19B MA Inhibitor DMFO19B RN NR2B-selective N-methyl-D-aspartate antagonists: synthesis and evaluation of 5-substituted benzimidazoles. J Med Chem. 2004 Apr 8;47(8):2089-96. DMFO19B RU https://pubmed.ncbi.nlm.nih.gov/15056006 DMJSBFU DI DMJSBFU DMJSBFU DN 2-(4-Phenoxy-benzyl)-3H-benzoimidazol-5-ylamine DMJSBFU MI TTLD29N DMJSBFU MN Glutamate receptor ionotropic NMDA 1 (NMDAR1) DMJSBFU MT DTT DMJSBFU MA Inhibitor DMJSBFU RN NR2B-selective N-methyl-D-aspartate antagonists: synthesis and evaluation of 5-substituted benzimidazoles. J Med Chem. 2004 Apr 8;47(8):2089-96. DMJSBFU RU https://pubmed.ncbi.nlm.nih.gov/15056006 DMJSBFU DI DMJSBFU DMJSBFU DN 2-(4-Phenoxy-benzyl)-3H-benzoimidazol-5-ylamine DMJSBFU MI TTN9D8E DMJSBFU MN Glutamate receptor ionotropic NMDA 2B (NMDAR2B) DMJSBFU MT DTT DMJSBFU MA Inhibitor DMJSBFU RN NR2B-selective N-methyl-D-aspartate antagonists: synthesis and evaluation of 5-substituted benzimidazoles. J Med Chem. 2004 Apr 8;47(8):2089-96. DMJSBFU RU https://pubmed.ncbi.nlm.nih.gov/15056006 DM7TBUJ DI DM7TBUJ DM7TBUJ DN 2-(4-phenoxyphenoxy)ethanamine DM7TBUJ MI TTO8QRU DM7TBUJ MN Group IIA phospholipase A2 (GIIA sPLA2) DM7TBUJ MT DTT DM7TBUJ MA Inhibitor DM7TBUJ RN Discovery of multitarget inhibitors by combining molecular docking with common pharmacophore matching. J Med Chem. 2008 Dec 25;51(24):7882-8. DM7TBUJ RU https://pubmed.ncbi.nlm.nih.gov/19090779 DM7TBUJ DI DM7TBUJ DM7TBUJ DN 2-(4-phenoxyphenoxy)ethanamine DM7TBUJ MI TTXZEAJ DM7TBUJ MN Leukotriene A-4 hydrolase (LTA4H) DM7TBUJ MT DTT DM7TBUJ MA Inhibitor DM7TBUJ RN Activation and inhibition of leukotriene A4 hydrolase aminopeptidase activity by diphenyl ether and derivatives. Bioorg Med Chem Lett. 2008 Dec 15;18(24):6549-52. DM7TBUJ RU https://pubmed.ncbi.nlm.nih.gov/18952425 DMSPOAT DI DMSPOAT DMSPOAT DN 2-(4-Phenoxy-phenyl)-1H-benzoimidazol-5-ylamine DMSPOAT MI TT9ABMF DMSPOAT MN Serine/threonine-protein kinase Chk2 (RAD53) DMSPOAT MT DTT DMSPOAT MA Inhibitor DMSPOAT RN Checkpoint kinase inhibitors: SAR and radioprotective properties of a series of 2-arylbenzimidazoles. J Med Chem. 2005 Mar 24;48(6):1873-85. DMSPOAT RU https://pubmed.ncbi.nlm.nih.gov/15771432 DMEQ063 DI DMEQ063 DMEQ063 DN 2-(4-Phenyl-butyl)-1,2-dihydro-indazol-3-one DMEQ063 MI TT2J34L DMEQ063 MN Arachidonate 5-lipoxygenase (5-LOX) DMEQ063 MT DTT DMEQ063 MA Inhibitor DMEQ063 RN Indazolinones, a new series of redox-active 5-lipoxygenase inhibitors with built-in selectivity and oral activity. J Med Chem. 1991 Mar;34(3):1028-36. DMEQ063 RU https://pubmed.ncbi.nlm.nih.gov/1848292 DMNJAV1 DI DMNJAV1 DMNJAV1 DN 2-(4-phenylbutyl)pyrido[2,3-d]pyrimidin-4(3H)-one DMNJAV1 MI TTWNV8U DMNJAV1 MN Nicotinic acid receptor (HCAR2) DMNJAV1 MT DTT DMNJAV1 MA Inhibitor DMNJAV1 RN Pyrido pyrimidinones as selective agonists of the high affinity niacin receptor GPR109A: optimization of in vitro activity. Bioorg Med Chem Lett. 2010 Sep 15;20(18):5426-30. DMNJAV1 RU https://pubmed.ncbi.nlm.nih.gov/20724150 DM98WVL DI DM98WVL DM98WVL DN 2-(4-Piperidin-1-ylmethylphenoxy)benzothiazole DM98WVL MI TTXZEAJ DM98WVL MN Leukotriene A-4 hydrolase (LTA4H) DM98WVL MT DTT DM98WVL MA Inhibitor DM98WVL RN Identification of a potent, selective, and orally active leukotriene a4 hydrolase inhibitor with anti-inflammatory activity. J Med Chem. 2008 Jul 24;51(14):4150-69. DM98WVL RU https://pubmed.ncbi.nlm.nih.gov/18588282 DMXC20R DI DMXC20R DMXC20R DN 2-(4-propylphenylsulfonyl)naphthalene-1,4-diol DMXC20R MI TTRVTMX DMXC20R MN Bacterial Beta-ketoacyl-ACP synthase III (Bact fabH) DMXC20R MT DTT DMXC20R MA Inhibitor DMXC20R RN Synthesis and biological evaluation of novel sulfonyl-naphthalene-1,4-diols as FabH inhibitors. Bioorg Med Chem Lett. 2008 Dec 15;18(24):6402-5. DMXC20R RU https://pubmed.ncbi.nlm.nih.gov/18996691 DMWPM9L DI DMWPM9L DMWPM9L DN 2-(4-Propyl-piperazin-1-yl)-quinoline DMWPM9L MI TT9JNIC DMWPM9L MN Histamine H3 receptor (H3R) DMWPM9L MT DTT DMWPM9L MA Inhibitor DMWPM9L RN 2-(4-alkylpiperazin-1-yl)quinolines as a new class of imidazole-free histamine H3 receptor antagonists. J Med Chem. 2005 Jan 13;48(1):306-11. DMWPM9L RU https://pubmed.ncbi.nlm.nih.gov/15634025 DMIOW3D DI DMIOW3D DMIOW3D DN 2-(4-tert-butylbenzylideneamino)ethanesulfonamide DMIOW3D MI TTANPDJ DMIOW3D MN Carbonic anhydrase II (CA-II) DMIOW3D MT DTT DMIOW3D MA Inhibitor DMIOW3D RN Carbonic anhydrase II-induced selection of inhibitors from a dynamic combinatorial library of Schiff's bases. Bioorg Med Chem Lett. 2009 Nov 1;19(21):6014-7. DMIOW3D RU https://pubmed.ncbi.nlm.nih.gov/19796939 DM1A4BS DI DM1A4BS DM1A4BS DN 2-(4-tert-Butyl-phenyl)-4,5-dihydro-1H-imidazole DM1A4BS MI TT6MSOK DM1A4BS MN 5-HT 1D receptor (HTR1D) DM1A4BS MT DTT DM1A4BS MA Inhibitor DM1A4BS RN 2-(Anilino)imidazolines and 2-(benzyl)imidazoline derivatives as h5-HT1D serotonin receptor ligands. Bioorg Med Chem Lett. 2004 Sep 20;14(18):4697-9. DM1A4BS RU https://pubmed.ncbi.nlm.nih.gov/15324890 DM1A4BS DI DM1A4BS DM1A4BS DN 2-(4-tert-Butyl-phenyl)-4,5-dihydro-1H-imidazole DM1A4BS MI TTNGILX DM1A4BS MN Adrenergic receptor alpha-1A (ADRA1A) DM1A4BS MT DTT DM1A4BS MA Inhibitor DM1A4BS RN 2-(Anilino)imidazolines and 2-(benzyl)imidazoline derivatives as h5-HT1D serotonin receptor ligands. Bioorg Med Chem Lett. 2004 Sep 20;14(18):4697-9. DM1A4BS RU https://pubmed.ncbi.nlm.nih.gov/15324890 DMED9FL DI DMED9FL DMED9FL DN 2-(4-tosylpiperazin-1-yl)nicotinonitrile DMED9FL MI TTN7BL9 DMED9FL MN Corticosteroid 11-beta-dehydrogenase 1 (HSD11B1) DMED9FL MT DTT DMED9FL MA Inhibitor DMED9FL RN Discovery and initial SAR of arylsulfonylpiperazine inhibitors of 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1). Bioorg Med Chem Lett. 2008 Jun 15;18(12):3513-6. DMED9FL RU https://pubmed.ncbi.nlm.nih.gov/18511278 DMTC5Y9 DI DMTC5Y9 DMTC5Y9 DN 2-(5,6-Dihydroxy-indan-1-ylidene)-malononitrile DMTC5Y9 MI TTGKNB4 DMTC5Y9 MN Epidermal growth factor receptor (EGFR) DMTC5Y9 MT DTT DMTC5Y9 MA Inhibitor DMTC5Y9 RN Tyrphostins. 2. Heterocyclic and alpha-substituted benzylidenemalononitrile tyrphostins as potent inhibitors of EGF receptor and ErbB2/neu tyrosine... J Med Chem. 1991 Jun;34(6):1896-907. DMTC5Y9 RU https://pubmed.ncbi.nlm.nih.gov/1676428 DMXRYDL DI DMXRYDL DMXRYDL DN 2-(5-Bromo-indole-1-sulfonyl)-benzoic acid DMXRYDL MI TTHWMFZ DMXRYDL MN Fatty acid-binding protein 4 (FABP4) DMXRYDL MT DTT DMXRYDL MA Inhibitor DMXRYDL RN Discovery of inhibitors of human adipocyte fatty acid-binding protein, a potential type 2 diabetes target. Bioorg Med Chem Lett. 2004 Sep 6;14(17):4445-8. DMXRYDL RU https://pubmed.ncbi.nlm.nih.gov/15357969 DM0ZB89 DI DM0ZB89 DM0ZB89 DN 2-(5-chloro-1H-benzo[d]imidazol-2-yl)quinoxaline DM0ZB89 MI TTJFY5U DM0ZB89 MN Adenosine A3 receptor (ADORA3) DM0ZB89 MT DTT DM0ZB89 MA Inhibitor DM0ZB89 RN 2-(Benzimidazol-2-yl)quinoxalines: a novel class of selective antagonists at human A(1) and A(3) adenosine receptors designed by 3D database search... J Med Chem. 2005 Dec 29;48(26):8253-60. DM0ZB89 RU https://pubmed.ncbi.nlm.nih.gov/16366607 DMSIJ17 DI DMSIJ17 DMSIJ17 DN 2-(5-cyano-1-pent-1-ynyl)-N6-methoxyadenosine DMSIJ17 MI TTK25J1 DMSIJ17 MN Adenosine A1 receptor (ADORA1) DMSIJ17 MT DTT DMSIJ17 MA Inhibitor DMSIJ17 RN N6-methoxy-2-alkynyladenosine derivatives as highly potent and selective ligands at the human A3 adenosine receptor. J Med Chem. 2007 Mar 22;50(6):1222-30. DMSIJ17 RU https://pubmed.ncbi.nlm.nih.gov/17309246 DMSIJ17 DI DMSIJ17 DMSIJ17 DN 2-(5-cyano-1-pent-1-ynyl)-N6-methoxyadenosine DMSIJ17 MI TTM2AOE DMSIJ17 MN Adenosine A2a receptor (ADORA2A) DMSIJ17 MT DTT DMSIJ17 MA Inhibitor DMSIJ17 RN N6-methoxy-2-alkynyladenosine derivatives as highly potent and selective ligands at the human A3 adenosine receptor. J Med Chem. 2007 Mar 22;50(6):1222-30. DMSIJ17 RU https://pubmed.ncbi.nlm.nih.gov/17309246 DMSIJ17 DI DMSIJ17 DMSIJ17 DN 2-(5-cyano-1-pent-1-ynyl)-N6-methoxyadenosine DMSIJ17 MI TTJFY5U DMSIJ17 MN Adenosine A3 receptor (ADORA3) DMSIJ17 MT DTT DMSIJ17 MA Inhibitor DMSIJ17 RN N6-methoxy-2-alkynyladenosine derivatives as highly potent and selective ligands at the human A3 adenosine receptor. J Med Chem. 2007 Mar 22;50(6):1222-30. DMSIJ17 RU https://pubmed.ncbi.nlm.nih.gov/17309246 DMHW5FT DI DMHW5FT DMHW5FT DN 2-(5-fluoro-1H-indol-3-yl)ethanamine DMHW5FT MI TTCPG9S DMHW5FT MN 5-HT 1E receptor (HTR1E) DMHW5FT MT DTT DMHW5FT MA Agonist DMHW5FT RN Molecular cloning and pharmacological characterization of the guinea pig 5-HT1E receptor. Eur J Pharmacol. 2004 Jan 26;484(2-3):127-39. DMHW5FT RU https://pubmed.ncbi.nlm.nih.gov/14744596 DMHW5FT DI DMHW5FT DMHW5FT DN 2-(5-fluoro-1H-indol-3-yl)ethanamine DMHW5FT MI TTXDKTO DMHW5FT MN Long transient receptor potential channel 8 (TRPM8) DMHW5FT MT DTT DMHW5FT MA Inhibitor DMHW5FT RN 5-benzyloxytryptamine as an antagonist of TRPM8. Bioorg Med Chem Lett. 2010 Dec 1;20(23):7076-9. DMHW5FT RU https://pubmed.ncbi.nlm.nih.gov/20965726 DMB3JG0 DI DMB3JG0 DMB3JG0 DN 2-(5-Hydroxy-naphthalen-1-yl)-benzooxazol-6-ol DMB3JG0 MI TTZAYWL DMB3JG0 MN Estrogen receptor (ESR) DMB3JG0 MT DTT DMB3JG0 MA Inhibitor DMB3JG0 RN Design and synthesis of aryl diphenolic azoles as potent and selective estrogen receptor-beta ligands. J Med Chem. 2004 Oct 7;47(21):5021-40. DMB3JG0 RU https://pubmed.ncbi.nlm.nih.gov/15456246 DMB3JG0 DI DMB3JG0 DMB3JG0 DN 2-(5-Hydroxy-naphthalen-1-yl)-benzooxazol-6-ol DMB3JG0 MI TTOM3J0 DMB3JG0 MN Estrogen receptor beta (ESR2) DMB3JG0 MT DTT DMB3JG0 MA Inhibitor DMB3JG0 RN Design and synthesis of aryl diphenolic azoles as potent and selective estrogen receptor-beta ligands. J Med Chem. 2004 Oct 7;47(21):5021-40. DMB3JG0 RU https://pubmed.ncbi.nlm.nih.gov/15456246 DM0P6A3 DI DM0P6A3 DM0P6A3 DN 2-(5-Mercapto-pentyl)-pentanedioic acid DM0P6A3 MI TT9G4N0 DM0P6A3 MN Glutamate carboxypeptidase II (GCPII) DM0P6A3 MT DTT DM0P6A3 MA Inhibitor DM0P6A3 RN Synthesis and biological evaluation of thiol-based inhibitors of glutamate carboxypeptidase II: discovery of an orally active GCP II inhibitor. J Med Chem. 2003 May 8;46(10):1989-96. DM0P6A3 RU https://pubmed.ncbi.nlm.nih.gov/12723961 DM1O0JD DI DM1O0JD DM1O0JD DN 2-(5-Methoxy-1H-indol-3-yl)-1-methyl-ethylamine DM1O0JD MI TTSQIFT DM1O0JD MN 5-HT 1A receptor (HTR1A) DM1O0JD MT DTT DM1O0JD MA Inhibitor DM1O0JD RN A novel and selective 5-HT2 receptor agonist with ocular hypotensive activity: (S)-(+)-1-(2-aminopropyl)-8,9-dihydropyrano[3,2-e]indole. J Med Chem. 2003 Sep 11;46(19):4188-95. DM1O0JD RU https://pubmed.ncbi.nlm.nih.gov/12954071 DM1O0JD DI DM1O0JD DM1O0JD DN 2-(5-Methoxy-1H-indol-3-yl)-1-methyl-ethylamine DM1O0JD MI TTJQOD7 DM1O0JD MN 5-HT 2A receptor (HTR2A) DM1O0JD MT DTT DM1O0JD MA Inhibitor DM1O0JD RN 1-((S)-2-aminopropyl)-1H-indazol-6-ol: a potent peripherally acting 5-HT2 receptor agonist with ocular hypotensive activity. J Med Chem. 2006 Jan 12;49(1):318-28. DM1O0JD RU https://pubmed.ncbi.nlm.nih.gov/16392816 DM1O0JD DI DM1O0JD DM1O0JD DN 2-(5-Methoxy-1H-indol-3-yl)-1-methyl-ethylamine DM1O0JD MI TT0K1SC DM1O0JD MN 5-HT 2B receptor (HTR2B) DM1O0JD MT DTT DM1O0JD MA Inhibitor DM1O0JD RN 1-((S)-2-aminopropyl)-1H-indazol-6-ol: a potent peripherally acting 5-HT2 receptor agonist with ocular hypotensive activity. J Med Chem. 2006 Jan 12;49(1):318-28. DM1O0JD RU https://pubmed.ncbi.nlm.nih.gov/16392816 DM1O0JD DI DM1O0JD DM1O0JD DN 2-(5-Methoxy-1H-indol-3-yl)-1-methyl-ethylamine DM1O0JD MI TTWJBZ5 DM1O0JD MN 5-HT 2C receptor (HTR2C) DM1O0JD MT DTT DM1O0JD MA Inhibitor DM1O0JD RN 1-((S)-2-aminopropyl)-1H-indazol-6-ol: a potent peripherally acting 5-HT2 receptor agonist with ocular hypotensive activity. J Med Chem. 2006 Jan 12;49(1):318-28. DM1O0JD RU https://pubmed.ncbi.nlm.nih.gov/16392816 DM2TU6W DI DM2TU6W DM2TU6W DN 2-(5-Nonyloxy-1H-indol-3-yl)-ethylamine DM2TU6W MI TTK8CXU DM2TU6W MN 5-HT 1B receptor (HTR1B) DM2TU6W MT DTT DM2TU6W MA Agonist DM2TU6W RN Identification of an amino acid residue important for binding of methiothepin and sumatriptan to the human 5-HT(1B) receptor. Eur J Pharmacol. 1999 Sep 10;380(2-3):171-81. DM2TU6W RU https://pubmed.ncbi.nlm.nih.gov/10513577 DM2TU6W DI DM2TU6W DM2TU6W DN 2-(5-Nonyloxy-1H-indol-3-yl)-ethylamine DM2TU6W MI TT6MSOK DM2TU6W MN 5-HT 1D receptor (HTR1D) DM2TU6W MT DTT DM2TU6W MA Inhibitor DM2TU6W RN 5-(Nonyloxy)tryptamine: a novel high-affinity 5-HT1D beta serotonin receptor agonist. J Med Chem. 1994 Sep 2;37(18):2828-30. DM2TU6W RU https://pubmed.ncbi.nlm.nih.gov/8071931 DMDZ9RK DI DMDZ9RK DMDZ9RK DN 2-(5-phenyl-furan-2-yl)-4,5-dihydro-1H-imidazole DMDZ9RK MI TT3WG5C DMDZ9RK MN Monoamine oxidase type A (MAO-A) DMDZ9RK MT DTT DMDZ9RK MA Inhibitor DMDZ9RK RN 3-[5-(4,5-dihydro-1H-imidazol-2-yl)-furan-2-yl]phenylamine (Amifuraline), a promising reversible and selective peripheral MAO-A inhibitor. J Med Chem. 2006 Sep 7;49(18):5578-86. DMDZ9RK RU https://pubmed.ncbi.nlm.nih.gov/16942031 DMDZ9RK DI DMDZ9RK DMDZ9RK DN 2-(5-phenyl-furan-2-yl)-4,5-dihydro-1H-imidazole DMDZ9RK MI TTGP7BY DMDZ9RK MN Monoamine oxidase type B (MAO-B) DMDZ9RK MT DTT DMDZ9RK MA Inhibitor DMDZ9RK RN 3-[5-(4,5-dihydro-1H-imidazol-2-yl)-furan-2-yl]phenylamine (Amifuraline), a promising reversible and selective peripheral MAO-A inhibitor. J Med Chem. 2006 Sep 7;49(18):5578-86. DMDZ9RK RU https://pubmed.ncbi.nlm.nih.gov/16942031 DMX6QMT DI DMX6QMT DMX6QMT DN 2-(5-Phenyl-oxazol-2-ylamino)-benzonitrile DMX6QMT MI TTUTJGQ DMX6QMT MN Vascular endothelial growth factor receptor 2 (KDR) DMX6QMT MT DTT DMX6QMT MA Inhibitor DMX6QMT RN Discovery and evaluation of 2-anilino-5-aryloxazoles as a novel class of VEGFR2 kinase inhibitors. J Med Chem. 2005 Mar 10;48(5):1610-9. DMX6QMT RU https://pubmed.ncbi.nlm.nih.gov/15743202 DMX6QMT DI DMX6QMT DMX6QMT DN 2-(5-Phenyl-oxazol-2-ylamino)-benzonitrile DMX6QMT MI TTDCBX5 DMX6QMT MN Vascular endothelial growth factor receptor 3 (FLT-4) DMX6QMT MT DTT DMX6QMT MA Inhibitor DMX6QMT RN Discovery and evaluation of 2-anilino-5-aryloxazoles as a novel class of VEGFR2 kinase inhibitors. J Med Chem. 2005 Mar 10;48(5):1610-9. DMX6QMT RU https://pubmed.ncbi.nlm.nih.gov/15743202 DMX6QMT DI DMX6QMT DMX6QMT DN 2-(5-Phenyl-oxazol-2-ylamino)-benzonitrile DMX6QMT MI TT1VAUK DMX6QMT MN VEGFR1 messenger RNA (VEGFR1 mRNA) DMX6QMT MT DTT DMX6QMT MA Inhibitor DMX6QMT RN Discovery and evaluation of 2-anilino-5-aryloxazoles as a novel class of VEGFR2 kinase inhibitors. J Med Chem. 2005 Mar 10;48(5):1610-9. DMX6QMT RU https://pubmed.ncbi.nlm.nih.gov/15743202 DM1AEK4 DI DM1AEK4 DM1AEK4 DN 2-(5-Thiophen-2-yl-1H-indol-3-yl)-ethylamine DM1AEK4 MI TTK8CXU DM1AEK4 MN 5-HT 1B receptor (HTR1B) DM1AEK4 MT DTT DM1AEK4 MA Inhibitor DM1AEK4 RN 5-Thienyltryptamine derivatives as serotonin 5-HT1B/1D receptor agonists: potential treatments for migraine. Bioorg Med Chem Lett. 2000 May 1;10(9):903-5. DM1AEK4 RU https://pubmed.ncbi.nlm.nih.gov/10853656 DM1AEK4 DI DM1AEK4 DM1AEK4 DN 2-(5-Thiophen-2-yl-1H-indol-3-yl)-ethylamine DM1AEK4 MI TT6MSOK DM1AEK4 MN 5-HT 1D receptor (HTR1D) DM1AEK4 MT DTT DM1AEK4 MA Inhibitor DM1AEK4 RN 5-Thienyltryptamine derivatives as serotonin 5-HT1B/1D receptor agonists: potential treatments for migraine. Bioorg Med Chem Lett. 2000 May 1;10(9):903-5. DM1AEK4 RU https://pubmed.ncbi.nlm.nih.gov/10853656 DMRBX1D DI DMRBX1D DMRBX1D DN 2-(6-amino-8-bromo-9H-purin-9-yl)ethanol DMRBX1D MI TTK25J1 DMRBX1D MN Adenosine A1 receptor (ADORA1) DMRBX1D MT DTT DMRBX1D MA Inhibitor DMRBX1D RN Insights into binding modes of adenosine A(2B) antagonists with ligand-based and receptor-based methods. Eur J Med Chem. 2010 Aug;45(8):3459-71. DMRBX1D RU https://pubmed.ncbi.nlm.nih.gov/20537438 DMRBX1D DI DMRBX1D DMRBX1D DN 2-(6-amino-8-bromo-9H-purin-9-yl)ethanol DMRBX1D MI TTM2AOE DMRBX1D MN Adenosine A2a receptor (ADORA2A) DMRBX1D MT DTT DMRBX1D MA Inhibitor DMRBX1D RN Insights into binding modes of adenosine A(2B) antagonists with ligand-based and receptor-based methods. Eur J Med Chem. 2010 Aug;45(8):3459-71. DMRBX1D RU https://pubmed.ncbi.nlm.nih.gov/20537438 DMRBX1D DI DMRBX1D DMRBX1D DN 2-(6-amino-8-bromo-9H-purin-9-yl)ethanol DMRBX1D MI TTNE7KG DMRBX1D MN Adenosine A2b receptor (ADORA2B) DMRBX1D MT DTT DMRBX1D MA Inhibitor DMRBX1D RN Insights into binding modes of adenosine A(2B) antagonists with ligand-based and receptor-based methods. Eur J Med Chem. 2010 Aug;45(8):3459-71. DMRBX1D RU https://pubmed.ncbi.nlm.nih.gov/20537438 DMTI1VO DI DMTI1VO DMTI1VO DN 2-(6-Cyclopentylamino-purin-9-yl)-ethanol DMTI1VO MI TTK25J1 DMTI1VO MN Adenosine A1 receptor (ADORA1) DMTI1VO MT DTT DMTI1VO MA Inhibitor DMTI1VO RN N6,9-disubstituted adenines: potent, selective antagonists at the A1 adenosine receptor. J Med Chem. 1991 Sep;34(9):2877-82. DMTI1VO RU https://pubmed.ncbi.nlm.nih.gov/1895305 DMXAVHT DI DMXAVHT DMXAVHT DN 2-(6-Hydroxy-naphthalen-1-yl)-benzooxazol-5-ol DMXAVHT MI TTZAYWL DMXAVHT MN Estrogen receptor (ESR) DMXAVHT MT DTT DMXAVHT MA Inhibitor DMXAVHT RN Design and synthesis of aryl diphenolic azoles as potent and selective estrogen receptor-beta ligands. J Med Chem. 2004 Oct 7;47(21):5021-40. DMXAVHT RU https://pubmed.ncbi.nlm.nih.gov/15456246 DMXAVHT DI DMXAVHT DMXAVHT DN 2-(6-Hydroxy-naphthalen-1-yl)-benzooxazol-5-ol DMXAVHT MI TTOM3J0 DMXAVHT MN Estrogen receptor beta (ESR2) DMXAVHT MT DTT DMXAVHT MA Inhibitor DMXAVHT RN Design and synthesis of aryl diphenolic azoles as potent and selective estrogen receptor-beta ligands. J Med Chem. 2004 Oct 7;47(21):5021-40. DMXAVHT RU https://pubmed.ncbi.nlm.nih.gov/15456246 DM3GQN2 DI DM3GQN2 DM3GQN2 DN 2-(6-Hydroxy-naphthalen-1-yl)-benzooxazol-6-ol DM3GQN2 MI TTZAYWL DM3GQN2 MN Estrogen receptor (ESR) DM3GQN2 MT DTT DM3GQN2 MA Inhibitor DM3GQN2 RN Design and synthesis of aryl diphenolic azoles as potent and selective estrogen receptor-beta ligands. J Med Chem. 2004 Oct 7;47(21):5021-40. DM3GQN2 RU https://pubmed.ncbi.nlm.nih.gov/15456246 DM3GQN2 DI DM3GQN2 DM3GQN2 DN 2-(6-Hydroxy-naphthalen-1-yl)-benzooxazol-6-ol DM3GQN2 MI TTOM3J0 DM3GQN2 MN Estrogen receptor beta (ESR2) DM3GQN2 MT DTT DM3GQN2 MA Inhibitor DM3GQN2 RN Design and synthesis of aryl diphenolic azoles as potent and selective estrogen receptor-beta ligands. J Med Chem. 2004 Oct 7;47(21):5021-40. DM3GQN2 RU https://pubmed.ncbi.nlm.nih.gov/15456246 DM715EC DI DM715EC DM715EC DN 2-(6-Hydroxy-naphthalen-2-yl)-benzooxazol-5-ol DM715EC MI TTZAYWL DM715EC MN Estrogen receptor (ESR) DM715EC MT DTT DM715EC MA Inhibitor DM715EC RN Design and synthesis of aryl diphenolic azoles as potent and selective estrogen receptor-beta ligands. J Med Chem. 2004 Oct 7;47(21):5021-40. DM715EC RU https://pubmed.ncbi.nlm.nih.gov/15456246 DM715EC DI DM715EC DM715EC DN 2-(6-Hydroxy-naphthalen-2-yl)-benzooxazol-5-ol DM715EC MI TTOM3J0 DM715EC MN Estrogen receptor beta (ESR2) DM715EC MT DTT DM715EC MA Inhibitor DM715EC RN Design and synthesis of aryl diphenolic azoles as potent and selective estrogen receptor-beta ligands. J Med Chem. 2004 Oct 7;47(21):5021-40. DM715EC RU https://pubmed.ncbi.nlm.nih.gov/15456246 DMANHOT DI DMANHOT DMANHOT DN 2-(6-Hydroxy-naphthalen-2-yl)-benzooxazol-6-ol DMANHOT MI TTZAYWL DMANHOT MN Estrogen receptor (ESR) DMANHOT MT DTT DMANHOT MA Inhibitor DMANHOT RN Design and synthesis of aryl diphenolic azoles as potent and selective estrogen receptor-beta ligands. J Med Chem. 2004 Oct 7;47(21):5021-40. DMANHOT RU https://pubmed.ncbi.nlm.nih.gov/15456246 DMANHOT DI DMANHOT DMANHOT DN 2-(6-Hydroxy-naphthalen-2-yl)-benzooxazol-6-ol DMANHOT MI TTOM3J0 DMANHOT MN Estrogen receptor beta (ESR2) DMANHOT MT DTT DMANHOT MA Inhibitor DMANHOT RN Design and synthesis of aryl diphenolic azoles as potent and selective estrogen receptor-beta ligands. J Med Chem. 2004 Oct 7;47(21):5021-40. DMANHOT RU https://pubmed.ncbi.nlm.nih.gov/15456246 DMKI6GQ DI DMKI6GQ DMKI6GQ DN 2-(6-Imidazol-1-yl-hexyl)-isoindole-1,3-dione DMKI6GQ MI TTKNWZ4 DMKI6GQ MN Thromboxane-A synthase (TBXAS1) DMKI6GQ MT DTT DMKI6GQ MA Inhibitor DMKI6GQ RN Thromboxane synthetase inhibitors and antihypertensive agents. 2. N-[(1H-imidazol-1-yl)alkyl]-1H-isoindole-1,3(2H)-diones and N-[(1H-1,2,4-triazol-... J Med Chem. 1986 May;29(5):816-9. DMKI6GQ RU https://pubmed.ncbi.nlm.nih.gov/3517332 DM41UYN DI DM41UYN DM41UYN DN 2-(6-Methoxy-indole-1-sulfonyl)-benzoic acid DM41UYN MI TTHWMFZ DM41UYN MN Fatty acid-binding protein 4 (FABP4) DM41UYN MT DTT DM41UYN MA Inhibitor DM41UYN RN Discovery of inhibitors of human adipocyte fatty acid-binding protein, a potential type 2 diabetes target. Bioorg Med Chem Lett. 2004 Sep 6;14(17):4445-8. DM41UYN RU https://pubmed.ncbi.nlm.nih.gov/15357969 DMZDNHQ DI DMZDNHQ DMZDNHQ DN 2-(6-morpholino-9H-purin-2-yl)phenol DMZDNHQ MI TTCJG29 DMZDNHQ MN Serine/threonine-protein kinase mTOR (mTOR) DMZDNHQ MT DTT DMZDNHQ MA Inhibitor DMZDNHQ RN Novel purine and pyrazolo[3,4-d]pyrimidine inhibitors of PI3 kinase-alpha: Hit to lead studies. Bioorg Med Chem Lett. 2010 Jan 15;20(2):636-9. DMZDNHQ RU https://pubmed.ncbi.nlm.nih.gov/19969455 DMR3Z1D DI DMR3Z1D DMR3Z1D DN 2-(6-phenylhexyl)pyrido[2,3-d]pyrimidin-4(3H)-one DMR3Z1D MI TTWNV8U DMR3Z1D MN Nicotinic acid receptor (HCAR2) DMR3Z1D MT DTT DMR3Z1D MA Inhibitor DMR3Z1D RN Pyrido pyrimidinones as selective agonists of the high affinity niacin receptor GPR109A: optimization of in vitro activity. Bioorg Med Chem Lett. 2010 Sep 15;20(18):5426-30. DMR3Z1D RU https://pubmed.ncbi.nlm.nih.gov/20724150 DMD2QVO DI DMD2QVO DMD2QVO DN 2-(7-(benzyloxy)-1H-indol-3-yl)ethanamine DMD2QVO MI TTXZEAJ DMD2QVO MN Leukotriene A-4 hydrolase (LTA4H) DMD2QVO MT DTT DMD2QVO MA Inhibitor DMD2QVO RN Discovery of multitarget inhibitors by combining molecular docking with common pharmacophore matching. J Med Chem. 2008 Dec 25;51(24):7882-8. DMD2QVO RU https://pubmed.ncbi.nlm.nih.gov/19090779 DMD2QVO DI DMD2QVO DMD2QVO DN 2-(7-(benzyloxy)-1H-indol-3-yl)ethanamine DMD2QVO MI TTXDKTO DMD2QVO MN Long transient receptor potential channel 8 (TRPM8) DMD2QVO MT DTT DMD2QVO MA Inhibitor DMD2QVO RN 5-benzyloxytryptamine as an antagonist of TRPM8. Bioorg Med Chem Lett. 2010 Dec 1;20(23):7076-9. DMD2QVO RU https://pubmed.ncbi.nlm.nih.gov/20965726 DMJAEZ8 DI DMJAEZ8 DMJAEZ8 DN 2-(7-phenylheptanoyl)oxazole-4-carbaldehyde DMJAEZ8 MI TTDP1UC DMJAEZ8 MN Fatty acid amide hydrolase (FAAH) DMJAEZ8 MT DTT DMJAEZ8 MA Inhibitor DMJAEZ8 RN Exploration of a fundamental substituent effect of alpha-ketoheterocycle enzyme inhibitors: Potent and selective inhibitors of fatty acid amide hyd... Bioorg Med Chem Lett. 2008 Nov 15;18(22):5842-6. DMJAEZ8 RU https://pubmed.ncbi.nlm.nih.gov/18639454 DMVSL49 DI DMVSL49 DMVSL49 DN 2-(7-phenylheptanoyl)oxazole-4-carbonitrile DMVSL49 MI TTDP1UC DMVSL49 MN Fatty acid amide hydrolase (FAAH) DMVSL49 MT DTT DMVSL49 MA Inhibitor DMVSL49 RN Exploration of a fundamental substituent effect of alpha-ketoheterocycle enzyme inhibitors: Potent and selective inhibitors of fatty acid amide hyd... Bioorg Med Chem Lett. 2008 Nov 15;18(22):5842-6. DMVSL49 RU https://pubmed.ncbi.nlm.nih.gov/18639454 DM9JMF2 DI DM9JMF2 DM9JMF2 DN 2-(7-phenylheptanoyl)oxazole-4-carboxamide DM9JMF2 MI TTDP1UC DM9JMF2 MN Fatty acid amide hydrolase (FAAH) DM9JMF2 MT DTT DM9JMF2 MA Inhibitor DM9JMF2 RN Exploration of a fundamental substituent effect of alpha-ketoheterocycle enzyme inhibitors: Potent and selective inhibitors of fatty acid amide hyd... Bioorg Med Chem Lett. 2008 Nov 15;18(22):5842-6. DM9JMF2 RU https://pubmed.ncbi.nlm.nih.gov/18639454 DM9BE2S DI DM9BE2S DM9BE2S DN 2-(7-phenylheptanoyl)oxazole-4-carboxylic acid DM9BE2S MI TTDP1UC DM9BE2S MN Fatty acid amide hydrolase (FAAH) DM9BE2S MT DTT DM9BE2S MA Inhibitor DM9BE2S RN Exploration of a fundamental substituent effect of alpha-ketoheterocycle enzyme inhibitors: Potent and selective inhibitors of fatty acid amide hyd... Bioorg Med Chem Lett. 2008 Nov 15;18(22):5842-6. DM9BE2S RU https://pubmed.ncbi.nlm.nih.gov/18639454 DM89RYN DI DM89RYN DM89RYN DN 2-(7-phenylheptanoyl)oxazole-5-carbonitrile DM89RYN MI TTDP1UC DM89RYN MN Fatty acid amide hydrolase (FAAH) DM89RYN MT DTT DM89RYN MA Inhibitor DM89RYN RN Exploration of a fundamental substituent effect of alpha-ketoheterocycle enzyme inhibitors: Potent and selective inhibitors of fatty acid amide hyd... Bioorg Med Chem Lett. 2008 Nov 15;18(22):5842-6. DM89RYN RU https://pubmed.ncbi.nlm.nih.gov/18639454 DMB53ML DI DMB53ML DMB53ML DN 2-(7-phenylheptanoyl)oxazole-5-carboxylic acid DMB53ML MI TTDP1UC DMB53ML MN Fatty acid amide hydrolase (FAAH) DMB53ML MT DTT DMB53ML MA Inhibitor DMB53ML RN Exploration of a fundamental substituent effect of alpha-ketoheterocycle enzyme inhibitors: Potent and selective inhibitors of fatty acid amide hyd... Bioorg Med Chem Lett. 2008 Nov 15;18(22):5842-6. DMB53ML RU https://pubmed.ncbi.nlm.nih.gov/18639454 DMLQ9WD DI DMLQ9WD DMLQ9WD DN 2-(8-Imidazol-1-yl-octyl)-isoindole-1,3-dione DMLQ9WD MI TTKNWZ4 DMLQ9WD MN Thromboxane-A synthase (TBXAS1) DMLQ9WD MT DTT DMLQ9WD MA Inhibitor DMLQ9WD RN Thromboxane synthetase inhibitors and antihypertensive agents. 2. N-[(1H-imidazol-1-yl)alkyl]-1H-isoindole-1,3(2H)-diones and N-[(1H-1,2,4-triazol-... J Med Chem. 1986 May;29(5):816-9. DMLQ9WD RU https://pubmed.ncbi.nlm.nih.gov/3517332 DMRW475 DI DMRW475 DMRW475 DN 2-(9,10-dihydroanthracen-9-yl)-N-methylethanamine DMRW475 MI TTJQOD7 DMRW475 MN 5-HT 2A receptor (HTR2A) DMRW475 MT DTT DMRW475 MA Inhibitor DMRW475 RN Synthesis, structure-affinity relationships, and modeling of AMDA analogs at 5-HT2A and H1 receptors: structural factors contributing to selectivity. Bioorg Med Chem. 2009 Sep 15;17(18):6496-504. DMRW475 RU https://pubmed.ncbi.nlm.nih.gov/19700330 DMRW475 DI DMRW475 DMRW475 DN 2-(9,10-dihydroanthracen-9-yl)-N-methylethanamine DMRW475 MI TTTIBOJ DMRW475 MN Histamine H1 receptor (H1R) DMRW475 MT DTT DMRW475 MA Inhibitor DMRW475 RN Synthesis, structure-affinity relationships, and modeling of AMDA analogs at 5-HT2A and H1 receptors: structural factors contributing to selectivity. Bioorg Med Chem. 2009 Sep 15;17(18):6496-504. DMRW475 RU https://pubmed.ncbi.nlm.nih.gov/19700330 DMPJ0O6 DI DMPJ0O6 DMPJ0O6 DN 2-(9-Benzyl-9H-purin-6-ylamino)-ethanol DMPJ0O6 MI TT1MPAY DMPJ0O6 MN GABA(A) receptor alpha-1 (GABRA1) DMPJ0O6 MT DTT DMPJ0O6 MA Inhibitor DMPJ0O6 RN Benzodiazepine receptor binding activity of 6,9-disubstituted purines. J Med Chem. 1989 May;32(5):1020-4. DMPJ0O6 RU https://pubmed.ncbi.nlm.nih.gov/2540330 DMPJ0O6 DI DMPJ0O6 DMPJ0O6 DN 2-(9-Benzyl-9H-purin-6-ylamino)-ethanol DMPJ0O6 MI TTZA1NY DMPJ0O6 MN GABA(A) receptor beta-2 (GABRB2) DMPJ0O6 MT DTT DMPJ0O6 MA Inhibitor DMPJ0O6 RN Benzodiazepine receptor binding activity of 6,9-disubstituted purines. J Med Chem. 1989 May;32(5):1020-4. DMPJ0O6 RU https://pubmed.ncbi.nlm.nih.gov/2540330 DMPJ0O6 DI DMPJ0O6 DMPJ0O6 DN 2-(9-Benzyl-9H-purin-6-ylamino)-ethanol DMPJ0O6 MI TT06RH5 DMPJ0O6 MN GABA(A) receptor gamma-2 (GABRG2) DMPJ0O6 MT DTT DMPJ0O6 MA Inhibitor DMPJ0O6 RN Benzodiazepine receptor binding activity of 6,9-disubstituted purines. J Med Chem. 1989 May;32(5):1020-4. DMPJ0O6 RU https://pubmed.ncbi.nlm.nih.gov/2540330 DMPJ0O6 DI DMPJ0O6 DMPJ0O6 DN 2-(9-Benzyl-9H-purin-6-ylamino)-ethanol DMPJ0O6 MI TTNJYV2 DMPJ0O6 MN Gamma-aminobutyric acid receptor (GAR) DMPJ0O6 MT DTT DMPJ0O6 MA Inhibitor DMPJ0O6 RN Benzodiazepine receptor binding activity of 6,9-disubstituted purines. J Med Chem. 1989 May;32(5):1020-4. DMPJ0O6 RU https://pubmed.ncbi.nlm.nih.gov/2540330 DMOUG6Y DI DMOUG6Y DMOUG6Y DN 2-(Acetylamino)-2-Deoxy-a-D-Glucopyranose DMOUG6Y MI TT1RS9F DMOUG6Y MN Acetylcholinesterase (AChE) DMOUG6Y MT DTT DMOUG6Y MA Inhibitor DMOUG6Y RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMOUG6Y RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMOUG6Y DI DMOUG6Y DMOUG6Y DN 2-(Acetylamino)-2-Deoxy-a-D-Glucopyranose DMOUG6Y MI TTL69WB DMOUG6Y MN Angiotensin-converting enzyme (ACE) DMOUG6Y MT DTT DMOUG6Y MA Inhibitor DMOUG6Y RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMOUG6Y RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMOUG6Y DI DMOUG6Y DMOUG6Y DN 2-(Acetylamino)-2-Deoxy-a-D-Glucopyranose DMOUG6Y MI TT1B5PU DMOUG6Y MN Glucosylceramidase (GBA) DMOUG6Y MT DTT DMOUG6Y MA Inhibitor DMOUG6Y RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMOUG6Y RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMB3YXG DI DMB3YXG DMB3YXG DN 2-(adamantan-1-ylamino)-5,5-diethyl-oxazol-4-one DMB3YXG MI TTN7BL9 DMB3YXG MN Corticosteroid 11-beta-dehydrogenase 1 (HSD11B1) DMB3YXG MT DTT DMB3YXG MA Inhibitor DMB3YXG RN Oxazolones as potent inhibitors of 11beta-hydroxysteroid dehydrogenase type 1. Bioorg Med Chem Lett. 2007 Sep 1;17(17):4837-40. DMB3YXG RU https://pubmed.ncbi.nlm.nih.gov/17600707 DM6P20R DI DM6P20R DM6P20R DN 2-(allyloxy)-N8-hydroxy-N1-phenyloctanediamide DM6P20R MI TTSHTOI DM6P20R MN Histone deacetylase 2 (HDAC2) DM6P20R MT DTT DM6P20R MA Inhibitor DM6P20R RN Omega-alkoxy analogues of SAHA (vorinostat) as inhibitors of HDAC: a study of chain-length and stereochemical dependence. Bioorg Med Chem Lett. 2007 Nov 15;17(22):6261-5. DM6P20R RU https://pubmed.ncbi.nlm.nih.gov/17892933 DMU4MIC DI DMU4MIC DMU4MIC DN 2-(Aminomethyl)-5-(1'-naphthethyl)tetrahydrofuran DMU4MIC MI TTAWNKZ DMU4MIC MN Norepinephrine transporter (NET) DMU4MIC MT DTT DMU4MIC MA Inhibitor DMU4MIC RN 2,5-Disubstituted tetrahydrofurans as selective serotonin re-uptake inhibitors. Bioorg Med Chem. 2009 Mar 1;17(5):2047-68. DMU4MIC RU https://pubmed.ncbi.nlm.nih.gov/19201198 DMU4MIC DI DMU4MIC DMU4MIC DN 2-(Aminomethyl)-5-(1'-naphthethyl)tetrahydrofuran DMU4MIC MI TT3ROYC DMU4MIC MN Serotonin transporter (SERT) DMU4MIC MT DTT DMU4MIC MA Inhibitor DMU4MIC RN 2,5-Disubstituted tetrahydrofurans as selective serotonin re-uptake inhibitors. Bioorg Med Chem. 2009 Mar 1;17(5):2047-68. DMU4MIC RU https://pubmed.ncbi.nlm.nih.gov/19201198 DMCUTY9 DI DMCUTY9 DMCUTY9 DN 2-(Aminomethyl)-5-(1'-naphthyl)tetrahydrofuran DMCUTY9 MI TTVBI8W DMCUTY9 MN Dopamine transporter (DAT) DMCUTY9 MT DTT DMCUTY9 MA Inhibitor DMCUTY9 RN 2,5-Disubstituted tetrahydrofurans as selective serotonin re-uptake inhibitors. Bioorg Med Chem. 2009 Mar 1;17(5):2047-68. DMCUTY9 RU https://pubmed.ncbi.nlm.nih.gov/19201198 DMCUTY9 DI DMCUTY9 DMCUTY9 DN 2-(Aminomethyl)-5-(1'-naphthyl)tetrahydrofuran DMCUTY9 MI TTAWNKZ DMCUTY9 MN Norepinephrine transporter (NET) DMCUTY9 MT DTT DMCUTY9 MA Inhibitor DMCUTY9 RN 2,5-Disubstituted tetrahydrofurans as selective serotonin re-uptake inhibitors. Bioorg Med Chem. 2009 Mar 1;17(5):2047-68. DMCUTY9 RU https://pubmed.ncbi.nlm.nih.gov/19201198 DMCUTY9 DI DMCUTY9 DMCUTY9 DN 2-(Aminomethyl)-5-(1'-naphthyl)tetrahydrofuran DMCUTY9 MI TT3ROYC DMCUTY9 MN Serotonin transporter (SERT) DMCUTY9 MT DTT DMCUTY9 MA Inhibitor DMCUTY9 RN 2,5-Disubstituted tetrahydrofurans as selective serotonin re-uptake inhibitors. Bioorg Med Chem. 2009 Mar 1;17(5):2047-68. DMCUTY9 RU https://pubmed.ncbi.nlm.nih.gov/19201198 DM157SO DI DM157SO DM157SO DN 2-(Aminomethyl)-5-(2'-naphthyl)tetrahydrofuran DM157SO MI TTVBI8W DM157SO MN Dopamine transporter (DAT) DM157SO MT DTT DM157SO MA Inhibitor DM157SO RN 2,5-Disubstituted tetrahydrofurans as selective serotonin re-uptake inhibitors. Bioorg Med Chem. 2009 Mar 1;17(5):2047-68. DM157SO RU https://pubmed.ncbi.nlm.nih.gov/19201198 DM157SO DI DM157SO DM157SO DN 2-(Aminomethyl)-5-(2'-naphthyl)tetrahydrofuran DM157SO MI TTAWNKZ DM157SO MN Norepinephrine transporter (NET) DM157SO MT DTT DM157SO MA Inhibitor DM157SO RN 2,5-Disubstituted tetrahydrofurans as selective serotonin re-uptake inhibitors. Bioorg Med Chem. 2009 Mar 1;17(5):2047-68. DM157SO RU https://pubmed.ncbi.nlm.nih.gov/19201198 DM157SO DI DM157SO DM157SO DN 2-(Aminomethyl)-5-(2'-naphthyl)tetrahydrofuran DM157SO MI TT3ROYC DM157SO MN Serotonin transporter (SERT) DM157SO MT DTT DM157SO MA Inhibitor DM157SO RN 2,5-Disubstituted tetrahydrofurans as selective serotonin re-uptake inhibitors. Bioorg Med Chem. 2009 Mar 1;17(5):2047-68. DM157SO RU https://pubmed.ncbi.nlm.nih.gov/19201198 DMEZ7O2 DI DMEZ7O2 DMEZ7O2 DN 2-(Aminomethyl)-5-phenethyltetrahydrofuran DMEZ7O2 MI TTVBI8W DMEZ7O2 MN Dopamine transporter (DAT) DMEZ7O2 MT DTT DMEZ7O2 MA Inhibitor DMEZ7O2 RN 2,5-Disubstituted tetrahydrofurans as selective serotonin re-uptake inhibitors. Bioorg Med Chem. 2009 Mar 1;17(5):2047-68. DMEZ7O2 RU https://pubmed.ncbi.nlm.nih.gov/19201198 DMEZ7O2 DI DMEZ7O2 DMEZ7O2 DN 2-(Aminomethyl)-5-phenethyltetrahydrofuran DMEZ7O2 MI TTAWNKZ DMEZ7O2 MN Norepinephrine transporter (NET) DMEZ7O2 MT DTT DMEZ7O2 MA Inhibitor DMEZ7O2 RN 2,5-Disubstituted tetrahydrofurans as selective serotonin re-uptake inhibitors. Bioorg Med Chem. 2009 Mar 1;17(5):2047-68. DMEZ7O2 RU https://pubmed.ncbi.nlm.nih.gov/19201198 DMEZ7O2 DI DMEZ7O2 DMEZ7O2 DN 2-(Aminomethyl)-5-phenethyltetrahydrofuran DMEZ7O2 MI TT3ROYC DMEZ7O2 MN Serotonin transporter (SERT) DMEZ7O2 MT DTT DMEZ7O2 MA Inhibitor DMEZ7O2 RN 2,5-Disubstituted tetrahydrofurans as selective serotonin re-uptake inhibitors. Bioorg Med Chem. 2009 Mar 1;17(5):2047-68. DMEZ7O2 RU https://pubmed.ncbi.nlm.nih.gov/19201198 DMO3G6Q DI DMO3G6Q DMO3G6Q DN 2-(benzofuran-2-yl)-6-morpholino-4H-pyran-4-one DMO3G6Q MI TTK3PY9 DMO3G6Q MN DNA-dependent protein kinase catalytic (PRKDC) DMO3G6Q MT DTT DMO3G6Q MA Inhibitor DMO3G6Q RN Pyranone, thiopyranone, and pyridone inhibitors of phosphatidylinositol 3-kinase related kinases. Structure-activity relationships for DNA-dependen... J Med Chem. 2007 Apr 19;50(8):1958-72. DMO3G6Q RU https://pubmed.ncbi.nlm.nih.gov/17371003 DMW27AC DI DMW27AC DMW27AC DN 2-(benzylamino)-5,5-diethyloxazol-4(5H)-one DMW27AC MI TTN7BL9 DMW27AC MN Corticosteroid 11-beta-dehydrogenase 1 (HSD11B1) DMW27AC MT DTT DMW27AC MA Inhibitor DMW27AC RN Oxazolones as potent inhibitors of 11beta-hydroxysteroid dehydrogenase type 1. Bioorg Med Chem Lett. 2007 Sep 1;17(17):4837-40. DMW27AC RU https://pubmed.ncbi.nlm.nih.gov/17600707 DM4X6I9 DI DM4X6I9 DM4X6I9 DN 2-(Benzylamino)-6-(3-acetamidophenyl)pyrazine DM4X6I9 MI TT0EOB8 DM4X6I9 MN B-Raf messenger RNA (BRAF mRNA) DM4X6I9 MT DTT DM4X6I9 MA Inhibitor DM4X6I9 RN Novel inhibitors of B-RAF based on a disubstituted pyrazine scaffold. Generation of a nanomolar lead. J Med Chem. 2006 Jan 12;49(1):407-16. DM4X6I9 RU https://pubmed.ncbi.nlm.nih.gov/16392826 DM3VJLZ DI DM3VJLZ DM3VJLZ DN 2-(benzylideneamino)ethanesulfonamide DM3VJLZ MI TTANPDJ DM3VJLZ MN Carbonic anhydrase II (CA-II) DM3VJLZ MT DTT DM3VJLZ MA Inhibitor DM3VJLZ RN Carbonic anhydrase II-induced selection of inhibitors from a dynamic combinatorial library of Schiff's bases. Bioorg Med Chem Lett. 2009 Nov 1;19(21):6014-7. DM3VJLZ RU https://pubmed.ncbi.nlm.nih.gov/19796939 DM48C7G DI DM48C7G DM48C7G DN 2-(benzyloxy)-N7-hydroxy-N1-phenylheptanediamide DM48C7G MI TTSHTOI DM48C7G MN Histone deacetylase 2 (HDAC2) DM48C7G MT DTT DM48C7G MA Inhibitor DM48C7G RN Omega-alkoxy analogues of SAHA (vorinostat) as inhibitors of HDAC: a study of chain-length and stereochemical dependence. Bioorg Med Chem Lett. 2007 Nov 15;17(22):6261-5. DM48C7G RU https://pubmed.ncbi.nlm.nih.gov/17892933 DME50RZ DI DME50RZ DME50RZ DN 2-(benzyloxy)naphthalene DME50RZ MI TTSJ6Q4 DME50RZ MN LOX-5 messenger RNA (ALOX5 mRNA) DME50RZ MT DTT DME50RZ MA Inhibitor DME50RZ RN Bioactivity-guided mapping and navigation of chemical space. Nat Chem Biol. 2009 Aug;5(8):585-92. DME50RZ RU https://pubmed.ncbi.nlm.nih.gov/19561619 DMSNCOW DI DMSNCOW DMSNCOW DN 2-(benzyloxyamino)-N-hydroxy-3-methylpentanamide DMSNCOW MI TT2LVK8 DMSNCOW MN Carbonic anhydrase IX (CA-IX) DMSNCOW MT DTT DMSNCOW MA Inhibitor DMSNCOW RN Carbonic anhydrase and matrix metalloproteinase inhibitors. Inhibition of human tumor-associated isozymes IX and cytosolic isozyme I and II with su... Bioorg Med Chem. 2007 Mar 15;15(6):2298-311. DMSNCOW RU https://pubmed.ncbi.nlm.nih.gov/17276072 DMHZJXG DI DMHZJXG DMHZJXG DN 2-(benzyloxyamino)-N-hydroxyacetamide DMHZJXG MI TT2LVK8 DMHZJXG MN Carbonic anhydrase IX (CA-IX) DMHZJXG MT DTT DMHZJXG MA Inhibitor DMHZJXG RN Carbonic anhydrase and matrix metalloproteinase inhibitors. Inhibition of human tumor-associated isozymes IX and cytosolic isozyme I and II with su... Bioorg Med Chem. 2007 Mar 15;15(6):2298-311. DMHZJXG RU https://pubmed.ncbi.nlm.nih.gov/17276072 DMOUKTH DI DMOUKTH DMOUKTH DN 2-(benzyloxyamino)-N-hydroxyhexanamide DMOUKTH MI TTANPDJ DMOUKTH MN Carbonic anhydrase II (CA-II) DMOUKTH MT DTT DMOUKTH MA Inhibitor DMOUKTH RN Carbonic anhydrase and matrix metalloproteinase inhibitors. Inhibition of human tumor-associated isozymes IX and cytosolic isozyme I and II with su... Bioorg Med Chem. 2007 Mar 15;15(6):2298-311. DMOUKTH RU https://pubmed.ncbi.nlm.nih.gov/17276072 DMOUKTH DI DMOUKTH DMOUKTH DN 2-(benzyloxyamino)-N-hydroxyhexanamide DMOUKTH MI TT2LVK8 DMOUKTH MN Carbonic anhydrase IX (CA-IX) DMOUKTH MT DTT DMOUKTH MA Inhibitor DMOUKTH RN Carbonic anhydrase and matrix metalloproteinase inhibitors. Inhibition of human tumor-associated isozymes IX and cytosolic isozyme I and II with su... Bioorg Med Chem. 2007 Mar 15;15(6):2298-311. DMOUKTH RU https://pubmed.ncbi.nlm.nih.gov/17276072 DM0C5O3 DI DM0C5O3 DM0C5O3 DN 2-(Biphenyl-2-yloxy)-N,N-dimethylethanamine DM0C5O3 MI TTO9X1H DM0C5O3 MN 5-HT 7 receptor (HTR7) DM0C5O3 MT DTT DM0C5O3 MA Inhibitor DM0C5O3 RN SAR studies on new bis-aryls 5-HT7 ligands: Synthesis and molecular modeling. Bioorg Med Chem. 2010 Mar 1;18(5):1958-67. DM0C5O3 RU https://pubmed.ncbi.nlm.nih.gov/20138771 DM9XZSC DI DM9XZSC DM9XZSC DN 2-(Biphenyl-2-ylthio)-N,N-dimethylethanamine DM9XZSC MI TTO9X1H DM9XZSC MN 5-HT 7 receptor (HTR7) DM9XZSC MT DTT DM9XZSC MA Inhibitor DM9XZSC RN SAR studies on new bis-aryls 5-HT7 ligands: Synthesis and molecular modeling. Bioorg Med Chem. 2010 Mar 1;18(5):1958-67. DM9XZSC RU https://pubmed.ncbi.nlm.nih.gov/20138771 DMU0GDY DI DMU0GDY DMU0GDY DN 2-(Biphenyl-3-ylthio)-N,N-dimethylethanamine DMU0GDY MI TTSQIFT DMU0GDY MN 5-HT 1A receptor (HTR1A) DMU0GDY MT DTT DMU0GDY MA Inhibitor DMU0GDY RN SAR studies on new bis-aryls 5-HT7 ligands: Synthesis and molecular modeling. Bioorg Med Chem. 2010 Mar 1;18(5):1958-67. DMU0GDY RU https://pubmed.ncbi.nlm.nih.gov/20138771 DMRQOKB DI DMRQOKB DMRQOKB DN 2-(biphenyl-4-yl)vinylboronic acid DMRQOKB MI TTHQPL7 DMRQOKB MN Carbonic anhydrase I (CA-I) DMRQOKB MT DTT DMRQOKB MA Inhibitor DMRQOKB RN Carbonic anhydrase inhibitors. Inhibition of the fungal beta-carbonic anhydrases from Candida albicans and Cryptococcus neoformans with boronic acids. Bioorg Med Chem Lett. 2009 May 15;19(10):2642-5. DMRQOKB RU https://pubmed.ncbi.nlm.nih.gov/19375309 DMRQOKB DI DMRQOKB DMRQOKB DN 2-(biphenyl-4-yl)vinylboronic acid DMRQOKB MI TTDP1UC DMRQOKB MN Fatty acid amide hydrolase (FAAH) DMRQOKB MT DTT DMRQOKB MA Inhibitor DMRQOKB RN Discovery of boronic acids as novel and potent inhibitors of fatty acid amide hydrolase. J Med Chem. 2008 Nov 27;51(22):7057-60. DMRQOKB RU https://pubmed.ncbi.nlm.nih.gov/18983140 DM3PWK7 DI DM3PWK7 DM3PWK7 DN 2-(biphenyl-4-ylsulfonamido)-N-hydroxyacetamide DM3PWK7 MI TTJ4QE7 DM3PWK7 MN Matrix metalloproteinase-14 (MMP-14) DM3PWK7 MT DTT DM3PWK7 MA Inhibitor DM3PWK7 RN Potent arylsulfonamide inhibitors of tumor necrosis factor-alpha converting enzyme able to reduce activated leukocyte cell adhesion molecule sheddi... J Med Chem. 2010 Mar 25;53(6):2622-35. DM3PWK7 RU https://pubmed.ncbi.nlm.nih.gov/20180536 DM3PWK7 DI DM3PWK7 DM3PWK7 DN 2-(biphenyl-4-ylsulfonamido)-N-hydroxyacetamide DM3PWK7 MI TT6AZXG DM3PWK7 MN TNF alpha converting enzyme (ADAM17) DM3PWK7 MT DTT DM3PWK7 MA Inhibitor DM3PWK7 RN Potent arylsulfonamide inhibitors of tumor necrosis factor-alpha converting enzyme able to reduce activated leukocyte cell adhesion molecule sheddi... J Med Chem. 2010 Mar 25;53(6):2622-35. DM3PWK7 RU https://pubmed.ncbi.nlm.nih.gov/20180536 DMH3YBR DI DMH3YBR DMH3YBR DN 2-(biphenyl-4-ylsulfonamido)pentanedioic acid DMH3YBR MI TTHY57M DMH3YBR MN Matrix metalloproteinase-13 (MMP-13) DMH3YBR MT DTT DMH3YBR MA Inhibitor DMH3YBR RN Ranking the selectivity of PubChem screening hits by activity-based protein profiling: MMP13 as a case study. Bioorg Med Chem. 2009 Feb 1;17(3):1101-8. DMH3YBR RU https://pubmed.ncbi.nlm.nih.gov/18364257 DMH3YBR DI DMH3YBR DMH3YBR DN 2-(biphenyl-4-ylsulfonamido)pentanedioic acid DMH3YBR MI TTGA1IV DMH3YBR MN Matrix metalloproteinase-8 (MMP-8) DMH3YBR MT DTT DMH3YBR MA Inhibitor DMH3YBR RN Ranking the selectivity of PubChem screening hits by activity-based protein profiling: MMP13 as a case study. Bioorg Med Chem. 2009 Feb 1;17(3):1101-8. DMH3YBR RU https://pubmed.ncbi.nlm.nih.gov/18364257 DMH3YBR DI DMH3YBR DMH3YBR DN 2-(biphenyl-4-ylsulfonamido)pentanedioic acid DMH3YBR MI TT6X50U DMH3YBR MN Matrix metalloproteinase-9 (MMP-9) DMH3YBR MT DTT DMH3YBR MA Inhibitor DMH3YBR RN Ranking the selectivity of PubChem screening hits by activity-based protein profiling: MMP13 as a case study. Bioorg Med Chem. 2009 Feb 1;17(3):1101-8. DMH3YBR RU https://pubmed.ncbi.nlm.nih.gov/18364257 DMCNV5J DI DMCNV5J DMCNV5J DN 2-(Biphenyl-4-ylsulfonyl)N-hydroxybenzamide DMCNV5J MI TTXZ0KQ DMCNV5J MN Matrix metalloproteinase-12 (MMP-12) DMCNV5J MT DTT DMCNV5J MA Inhibitor DMCNV5J RN Design, synthesis, biological evaluation, and NMR studies of a new series of arylsulfones as selective and potent matrix metalloproteinase-12 inhib... J Med Chem. 2009 Oct 22;52(20):6347-61. DMCNV5J RU https://pubmed.ncbi.nlm.nih.gov/19775099 DMCNV5J DI DMCNV5J DMCNV5J DN 2-(Biphenyl-4-ylsulfonyl)N-hydroxybenzamide DMCNV5J MI TTHY57M DMCNV5J MN Matrix metalloproteinase-13 (MMP-13) DMCNV5J MT DTT DMCNV5J MA Inhibitor DMCNV5J RN Design, synthesis, biological evaluation, and NMR studies of a new series of arylsulfones as selective and potent matrix metalloproteinase-12 inhib... J Med Chem. 2009 Oct 22;52(20):6347-61. DMCNV5J RU https://pubmed.ncbi.nlm.nih.gov/19775099 DMCNV5J DI DMCNV5J DMCNV5J DN 2-(Biphenyl-4-ylsulfonyl)N-hydroxybenzamide DMCNV5J MI TTJ4QE7 DMCNV5J MN Matrix metalloproteinase-14 (MMP-14) DMCNV5J MT DTT DMCNV5J MA Inhibitor DMCNV5J RN Design, synthesis, biological evaluation, and NMR studies of a new series of arylsulfones as selective and potent matrix metalloproteinase-12 inhib... J Med Chem. 2009 Oct 22;52(20):6347-61. DMCNV5J RU https://pubmed.ncbi.nlm.nih.gov/19775099 DMCNV5J DI DMCNV5J DMCNV5J DN 2-(Biphenyl-4-ylsulfonyl)N-hydroxybenzamide DMCNV5J MI TTLM12X DMCNV5J MN Matrix metalloproteinase-2 (MMP-2) DMCNV5J MT DTT DMCNV5J MA Inhibitor DMCNV5J RN Design, synthesis, biological evaluation, and NMR studies of a new series of arylsulfones as selective and potent matrix metalloproteinase-12 inhib... J Med Chem. 2009 Oct 22;52(20):6347-61. DMCNV5J RU https://pubmed.ncbi.nlm.nih.gov/19775099 DMCNV5J DI DMCNV5J DMCNV5J DN 2-(Biphenyl-4-ylsulfonyl)N-hydroxybenzamide DMCNV5J MI TTYRF5E DMCNV5J MN Matrix metalloproteinase-21 (MMP-21) DMCNV5J MT DTT DMCNV5J MA Inhibitor DMCNV5J RN Design, synthesis, biological evaluation, and NMR studies of a new series of arylsulfones as selective and potent matrix metalloproteinase-12 inhib... J Med Chem. 2009 Oct 22;52(20):6347-61. DMCNV5J RU https://pubmed.ncbi.nlm.nih.gov/19775099 DMCNV5J DI DMCNV5J DMCNV5J DN 2-(Biphenyl-4-ylsulfonyl)N-hydroxybenzamide DMCNV5J MI TTGA1IV DMCNV5J MN Matrix metalloproteinase-8 (MMP-8) DMCNV5J MT DTT DMCNV5J MA Inhibitor DMCNV5J RN Design, synthesis, biological evaluation, and NMR studies of a new series of arylsulfones as selective and potent matrix metalloproteinase-12 inhib... J Med Chem. 2009 Oct 22;52(20):6347-61. DMCNV5J RU https://pubmed.ncbi.nlm.nih.gov/19775099 DMCNV5J DI DMCNV5J DMCNV5J DN 2-(Biphenyl-4-ylsulfonyl)N-hydroxybenzamide DMCNV5J MI TT6X50U DMCNV5J MN Matrix metalloproteinase-9 (MMP-9) DMCNV5J MT DTT DMCNV5J MA Inhibitor DMCNV5J RN Design, synthesis, biological evaluation, and NMR studies of a new series of arylsulfones as selective and potent matrix metalloproteinase-12 inhib... J Med Chem. 2009 Oct 22;52(20):6347-61. DMCNV5J RU https://pubmed.ncbi.nlm.nih.gov/19775099 DMFO7CH DI DMFO7CH DMFO7CH DN 2-(butylthiomethyl)-5-hydroxy-4H-pyran-4-one DMFO7CH MI TTULVH8 DMFO7CH MN Tyrosinase (TYR) DMFO7CH MT DTT DMFO7CH MA Inhibitor DMFO7CH RN Kojyl thioether derivatives having both tyrosinase inhibitory and anti-inflammatory properties. Bioorg Med Chem Lett. 2010 Nov 15;20(22):6569-71. DMFO7CH RU https://pubmed.ncbi.nlm.nih.gov/20934336 DMA6P4J DI DMA6P4J DMA6P4J DN 2-(Carbazole-9-sulfonyl)-benzoic acid DMA6P4J MI TTHWMFZ DMA6P4J MN Fatty acid-binding protein 4 (FABP4) DMA6P4J MT DTT DMA6P4J MA Inhibitor DMA6P4J RN Discovery of inhibitors of human adipocyte fatty acid-binding protein, a potential type 2 diabetes target. Bioorg Med Chem Lett. 2004 Sep 6;14(17):4445-8. DMA6P4J RU https://pubmed.ncbi.nlm.nih.gov/15357969 DMA6P4J DI DMA6P4J DMA6P4J DN 2-(Carbazole-9-sulfonyl)-benzoic acid DMA6P4J MI TTNT2S6 DMA6P4J MN Fatty acid-binding protein 5 (FABP5) DMA6P4J MT DTT DMA6P4J MA Inhibitor DMA6P4J RN Discovery of inhibitors of human adipocyte fatty acid-binding protein, a potential type 2 diabetes target. Bioorg Med Chem Lett. 2004 Sep 6;14(17):4445-8. DMA6P4J RU https://pubmed.ncbi.nlm.nih.gov/15357969 DMQ2SNL DI DMQ2SNL DMQ2SNL DN 2-(carboxymethylamino)-2-oxoacetic acid DMQ2SNL MI TTMHFRY DMQ2SNL MN HIF-prolyl hydroxylase 1 (HPH-1) DMQ2SNL MT DTT DMQ2SNL MA Inhibitor DMQ2SNL RN Design, synthesis, enzyme-inhibitory activity, and effect on human cancer cells of a novel series of jumonji domain-containing protein 2 histone de... J Med Chem. 2010 Aug 12;53(15):5629-38. DMQ2SNL RU https://pubmed.ncbi.nlm.nih.gov/20684604 DM0PA6I DI DM0PA6I DM0PA6I DN 2-(cinnamyloxy)pyrido[2,3-d]pyrimidin-4(3H)-one DM0PA6I MI TTWNV8U DM0PA6I MN Nicotinic acid receptor (HCAR2) DM0PA6I MT DTT DM0PA6I MA Inhibitor DM0PA6I RN Pyrido pyrimidinones as selective agonists of the high affinity niacin receptor GPR109A: optimization of in vitro activity. Bioorg Med Chem Lett. 2010 Sep 15;20(18):5426-30. DM0PA6I RU https://pubmed.ncbi.nlm.nih.gov/20724150 DMQ9ODG DI DMQ9ODG DMQ9ODG DN 2-(cycloheptylamino)-2-oxoethyl 2-aminonicotinate DMQ9ODG MI TTEAID7 DMQ9ODG MN Trypanosoma Cruzipain (Trypano CYSP) DMQ9ODG MT DTT DMQ9ODG MA Inhibitor DMQ9ODG RN Divergent modes of enzyme inhibition in a homologous structure-activity series. J Med Chem. 2009 Aug 27;52(16):5005-8. DMQ9ODG RU https://pubmed.ncbi.nlm.nih.gov/19637873 DMPT0MB DI DMPT0MB DMPT0MB DN 2-(cyclohexylamino)benzoic acid DMPT0MB MI TTTU902 DMPT0MB MN Checkpoint kinase-1 (CHK1) DMPT0MB MT DTT DMPT0MB MA Inhibitor DMPT0MB RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DMPT0MB RU https://pubmed.ncbi.nlm.nih.gov/10592235 DM2CAI1 DI DM2CAI1 DM2CAI1 DN 2-(cyclohexylthiomethyl)-5-hydroxy-4H-pyran-4-one DM2CAI1 MI TTULVH8 DM2CAI1 MN Tyrosinase (TYR) DM2CAI1 MT DTT DM2CAI1 MA Inhibitor DM2CAI1 RN Kojyl thioether derivatives having both tyrosinase inhibitory and anti-inflammatory properties. Bioorg Med Chem Lett. 2010 Nov 15;20(22):6569-71. DM2CAI1 RU https://pubmed.ncbi.nlm.nih.gov/20934336 DMAPW5K DI DMAPW5K DMAPW5K DN 2-(cyclooctylamino)-5,5-diethyloxazol-4(5H)-one DMAPW5K MI TTN7BL9 DMAPW5K MN Corticosteroid 11-beta-dehydrogenase 1 (HSD11B1) DMAPW5K MT DTT DMAPW5K MA Inhibitor DMAPW5K RN Oxazolones as potent inhibitors of 11beta-hydroxysteroid dehydrogenase type 1. Bioorg Med Chem Lett. 2007 Sep 1;17(17):4837-40. DMAPW5K RU https://pubmed.ncbi.nlm.nih.gov/17600707 DMZVMDO DI DMZVMDO DMZVMDO DN 2-(difluoromethyl)-9H-carbazole DMZVMDO MI TTBGTCW DMZVMDO MN Kinesin spindle messenger RNA (KIF11 mRNA) DMZVMDO MT DTT DMZVMDO MA Inhibitor DMZVMDO RN Kinesin spindle protein (KSP) inhibitors with 2,3-fused indole scaffolds. J Med Chem. 2010 Jul 8;53(13):5054-8. DMZVMDO RU https://pubmed.ncbi.nlm.nih.gov/20521839 DMS7WQD DI DMS7WQD DMS7WQD DN 2-(ethoxycarbonyl)-1H-indole-5-carboxylic acid DMS7WQD MI TT9JNIC DMS7WQD MN Histamine H3 receptor (H3R) DMS7WQD MT DTT DMS7WQD MA Inhibitor DMS7WQD RN 5-hydroxyindole-2-carboxylic acid amides: novel histamine-3 receptor inverse agonists for the treatment of obesity. J Med Chem. 2009 Jul 9;52(13):3855-68. DMS7WQD RU https://pubmed.ncbi.nlm.nih.gov/19456097 DM8GJCU DI DM8GJCU DM8GJCU DN 2-(ethylthiomethyl)-5-hydroxy-4H-pyran-4-one DM8GJCU MI TTULVH8 DM8GJCU MN Tyrosinase (TYR) DM8GJCU MT DTT DM8GJCU MA Inhibitor DM8GJCU RN Kojyl thioether derivatives having both tyrosinase inhibitory and anti-inflammatory properties. Bioorg Med Chem Lett. 2010 Nov 15;20(22):6569-71. DM8GJCU RU https://pubmed.ncbi.nlm.nih.gov/20934336 DM6BHUF DI DM6BHUF DM6BHUF DN 2-(furan-2-yl)-6-morpholino-4H-pyran-4-one DM6BHUF MI TTK3PY9 DM6BHUF MN DNA-dependent protein kinase catalytic (PRKDC) DM6BHUF MT DTT DM6BHUF MA Inhibitor DM6BHUF RN Pyranone, thiopyranone, and pyridone inhibitors of phosphatidylinositol 3-kinase related kinases. Structure-activity relationships for DNA-dependen... J Med Chem. 2007 Apr 19;50(8):1958-72. DM6BHUF RU https://pubmed.ncbi.nlm.nih.gov/17371003 DM490BL DI DM490BL DM490BL DN 2-(heptylthiomethyl)-5-hydroxy-4H-pyran-4-one DM490BL MI TTULVH8 DM490BL MN Tyrosinase (TYR) DM490BL MT DTT DM490BL MA Inhibitor DM490BL RN Kojyl thioether derivatives having both tyrosinase inhibitory and anti-inflammatory properties. Bioorg Med Chem Lett. 2010 Nov 15;20(22):6569-71. DM490BL RU https://pubmed.ncbi.nlm.nih.gov/20934336 DM7YLTS DI DM7YLTS DM7YLTS DN 2-(hex-1-ynyl)-N6-methoxyadenosine DM7YLTS MI TTK25J1 DM7YLTS MN Adenosine A1 receptor (ADORA1) DM7YLTS MT DTT DM7YLTS MA Inhibitor DM7YLTS RN N6-methoxy-2-alkynyladenosine derivatives as highly potent and selective ligands at the human A3 adenosine receptor. J Med Chem. 2007 Mar 22;50(6):1222-30. DM7YLTS RU https://pubmed.ncbi.nlm.nih.gov/17309246 DM7YLTS DI DM7YLTS DM7YLTS DN 2-(hex-1-ynyl)-N6-methoxyadenosine DM7YLTS MI TTM2AOE DM7YLTS MN Adenosine A2a receptor (ADORA2A) DM7YLTS MT DTT DM7YLTS MA Inhibitor DM7YLTS RN N6-methoxy-2-alkynyladenosine derivatives as highly potent and selective ligands at the human A3 adenosine receptor. J Med Chem. 2007 Mar 22;50(6):1222-30. DM7YLTS RU https://pubmed.ncbi.nlm.nih.gov/17309246 DM7YLTS DI DM7YLTS DM7YLTS DN 2-(hex-1-ynyl)-N6-methoxyadenosine DM7YLTS MI TTJFY5U DM7YLTS MN Adenosine A3 receptor (ADORA3) DM7YLTS MT DTT DM7YLTS MA Inhibitor DM7YLTS RN N6-methoxy-2-alkynyladenosine derivatives as highly potent and selective ligands at the human A3 adenosine receptor. J Med Chem. 2007 Mar 22;50(6):1222-30. DM7YLTS RU https://pubmed.ncbi.nlm.nih.gov/17309246 DM235Q4 DI DM235Q4 DM235Q4 DN 2-(hexylthiomethyl)-5-hydroxy-4H-pyran-4-one DM235Q4 MI TTULVH8 DM235Q4 MN Tyrosinase (TYR) DM235Q4 MT DTT DM235Q4 MA Inhibitor DM235Q4 RN Kojyl thioether derivatives having both tyrosinase inhibitory and anti-inflammatory properties. Bioorg Med Chem Lett. 2010 Nov 15;20(22):6569-71. DM235Q4 RU https://pubmed.ncbi.nlm.nih.gov/20934336 DMOVYXT DI DMOVYXT DMOVYXT DN 2-(indolin-1yl)-melatonin DMOVYXT MI TT0WAIE DMOVYXT MN Melatonin receptor type 1A (MTNR1A) DMOVYXT MT DTT DMOVYXT MA Antagonist DMOVYXT RN 2-[(2,3-dihydro-1H-indol-1-yl)methyl]melatonin analogues: a novel class of MT2-selective melatonin receptor antagonists. J Med Chem. 2009 Feb 12;52(3):826-33. DMOVYXT RU https://pubmed.ncbi.nlm.nih.gov/19193160 DM1SIQD DI DM1SIQD DM1SIQD DN 2-(methylsulfonyl)naphthalene-1,4-diol DM1SIQD MI TTRVTMX DM1SIQD MN Bacterial Beta-ketoacyl-ACP synthase III (Bact fabH) DM1SIQD MT DTT DM1SIQD MA Inhibitor DM1SIQD RN Synthesis and biological evaluation of novel sulfonyl-naphthalene-1,4-diols as FabH inhibitors. Bioorg Med Chem Lett. 2008 Dec 15;18(24):6402-5. DM1SIQD RU https://pubmed.ncbi.nlm.nih.gov/18996691 DMM52D3 DI DMM52D3 DMM52D3 DN 2-(methylsulfonylthio)ethyl 2-propylpentanoate DMM52D3 MI TTBH0VX DMM52D3 MN Histone deacetylase (HDAC) DMM52D3 MT DTT DMM52D3 MA Inhibitor DMM52D3 RN New sulfurated derivatives of valproic acid with enhanced histone deacetylase inhibitory activity. Bioorg Med Chem Lett. 2008 Mar 15;18(6):1893-7. DMM52D3 RU https://pubmed.ncbi.nlm.nih.gov/18294844 DMM52D3 DI DMM52D3 DMM52D3 DN 2-(methylsulfonylthio)ethyl 2-propylpentanoate DMM52D3 MI TT6R7JZ DMM52D3 MN Histone deacetylase 1 (HDAC1) DMM52D3 MT DTT DMM52D3 MA Inhibitor DMM52D3 RN New sulfurated derivatives of valproic acid with enhanced histone deacetylase inhibitory activity. Bioorg Med Chem Lett. 2008 Mar 15;18(6):1893-7. DMM52D3 RU https://pubmed.ncbi.nlm.nih.gov/18294844 DMM52D3 DI DMM52D3 DMM52D3 DN 2-(methylsulfonylthio)ethyl 2-propylpentanoate DMM52D3 MI TTYHPU6 DMM52D3 MN Histone deacetylase 10 (HDAC10) DMM52D3 MT DTT DMM52D3 MA Inhibitor DMM52D3 RN New sulfurated derivatives of valproic acid with enhanced histone deacetylase inhibitory activity. Bioorg Med Chem Lett. 2008 Mar 15;18(6):1893-7. DMM52D3 RU https://pubmed.ncbi.nlm.nih.gov/18294844 DMM52D3 DI DMM52D3 DMM52D3 DN 2-(methylsulfonylthio)ethyl 2-propylpentanoate DMM52D3 MI TTSHTOI DMM52D3 MN Histone deacetylase 2 (HDAC2) DMM52D3 MT DTT DMM52D3 MA Inhibitor DMM52D3 RN New sulfurated derivatives of valproic acid with enhanced histone deacetylase inhibitory activity. Bioorg Med Chem Lett. 2008 Mar 15;18(6):1893-7. DMM52D3 RU https://pubmed.ncbi.nlm.nih.gov/18294844 DMM52D3 DI DMM52D3 DMM52D3 DN 2-(methylsulfonylthio)ethyl 2-propylpentanoate DMM52D3 MI TTTQGH8 DMM52D3 MN Histone deacetylase 4 (HDAC4) DMM52D3 MT DTT DMM52D3 MA Inhibitor DMM52D3 RN New sulfurated derivatives of valproic acid with enhanced histone deacetylase inhibitory activity. Bioorg Med Chem Lett. 2008 Mar 15;18(6):1893-7. DMM52D3 RU https://pubmed.ncbi.nlm.nih.gov/18294844 DMM52D3 DI DMM52D3 DMM52D3 DN 2-(methylsulfonylthio)ethyl 2-propylpentanoate DMM52D3 MI TT5ZKDI DMM52D3 MN Histone deacetylase 6 (HDAC6) DMM52D3 MT DTT DMM52D3 MA Inhibitor DMM52D3 RN New sulfurated derivatives of valproic acid with enhanced histone deacetylase inhibitory activity. Bioorg Med Chem Lett. 2008 Mar 15;18(6):1893-7. DMM52D3 RU https://pubmed.ncbi.nlm.nih.gov/18294844 DMM52D3 DI DMM52D3 DMM52D3 DN 2-(methylsulfonylthio)ethyl 2-propylpentanoate DMM52D3 MI TTT6LFV DMM52D3 MN Histone deacetylase 8 (HDAC8) DMM52D3 MT DTT DMM52D3 MA Inhibitor DMM52D3 RN New sulfurated derivatives of valproic acid with enhanced histone deacetylase inhibitory activity. Bioorg Med Chem Lett. 2008 Mar 15;18(6):1893-7. DMM52D3 RU https://pubmed.ncbi.nlm.nih.gov/18294844 DM15BA7 DI DM15BA7 DM15BA7 DN 2-(m-tolylethynyl)pyrimidine DM15BA7 MI TTHS256 DM15BA7 MN Metabotropic glutamate receptor 5 (mGluR5) DM15BA7 MT DTT DM15BA7 MA Inhibitor DM15BA7 RN Discovery of molecular switches that modulate modes of metabotropic glutamate receptor subtype 5 (mGlu5) pharmacology in vitro and in vivo within a... J Med Chem. 2009 Jul 23;52(14):4103-6. DM15BA7 RU https://pubmed.ncbi.nlm.nih.gov/19537763 DMRNOM6 DI DMRNOM6 DMRNOM6 DN 2-(N-(2-Ffuorophenyl)pyrrol-3-yl) acetic acid DMRNOM6 MI TT8NGED DMRNOM6 MN Prostaglandin G/H synthase 1 (COX-1) DMRNOM6 MT DTT DMRNOM6 MA Inhibitor DMRNOM6 RN Synthesis and biological activity of new anti-inflammatory compounds containing the 1,4-benzodioxine and/or pyrrole system. Bioorg Med Chem. 2007 Jul 15;15(14):4876-90. DMRNOM6 RU https://pubmed.ncbi.nlm.nih.gov/17517512 DMRNOM6 DI DMRNOM6 DMRNOM6 DN 2-(N-(2-Ffuorophenyl)pyrrol-3-yl) acetic acid DMRNOM6 MI TTVKILB DMRNOM6 MN Prostaglandin G/H synthase 2 (COX-2) DMRNOM6 MT DTT DMRNOM6 MA Inhibitor DMRNOM6 RN Synthesis and biological activity of new anti-inflammatory compounds containing the 1,4-benzodioxine and/or pyrrole system. Bioorg Med Chem. 2007 Jul 15;15(14):4876-90. DMRNOM6 RU https://pubmed.ncbi.nlm.nih.gov/17517512 DMCL9E6 DI DMCL9E6 DMCL9E6 DN 2-(N-(2-fluorophenyl)pyrrol-2-yl) acetic acid DMCL9E6 MI TT8NGED DMCL9E6 MN Prostaglandin G/H synthase 1 (COX-1) DMCL9E6 MT DTT DMCL9E6 MA Inhibitor DMCL9E6 RN Synthesis and biological activity of new anti-inflammatory compounds containing the 1,4-benzodioxine and/or pyrrole system. Bioorg Med Chem. 2007 Jul 15;15(14):4876-90. DMCL9E6 RU https://pubmed.ncbi.nlm.nih.gov/17517512 DMCL9E6 DI DMCL9E6 DMCL9E6 DN 2-(N-(2-fluorophenyl)pyrrol-2-yl) acetic acid DMCL9E6 MI TTVKILB DMCL9E6 MN Prostaglandin G/H synthase 2 (COX-2) DMCL9E6 MT DTT DMCL9E6 MA Inhibitor DMCL9E6 RN Synthesis and biological activity of new anti-inflammatory compounds containing the 1,4-benzodioxine and/or pyrrole system. Bioorg Med Chem. 2007 Jul 15;15(14):4876-90. DMCL9E6 RU https://pubmed.ncbi.nlm.nih.gov/17517512 DMVR248 DI DMVR248 DMVR248 DN 2-(N,N-Diethylamino)-3'-chloropropiophenone DMVR248 MI TTVBI8W DMVR248 MN Dopamine transporter (DAT) DMVR248 MT DTT DMVR248 MA Inhibitor DMVR248 RN Synthesis and biological evaluation of bupropion analogues as potential pharmacotherapies for cocaine addiction. J Med Chem. 2009 Nov 12;52(21):6768-81. DMVR248 RU https://pubmed.ncbi.nlm.nih.gov/19821577 DMVR248 DI DMVR248 DMVR248 DN 2-(N,N-Diethylamino)-3'-chloropropiophenone DMVR248 MI TTAWNKZ DMVR248 MN Norepinephrine transporter (NET) DMVR248 MT DTT DMVR248 MA Inhibitor DMVR248 RN Synthesis and biological evaluation of bupropion analogues as potential pharmacotherapies for cocaine addiction. J Med Chem. 2009 Nov 12;52(21):6768-81. DMVR248 RU https://pubmed.ncbi.nlm.nih.gov/19821577 DMHYKR8 DI DMHYKR8 DMHYKR8 DN 2-(N''-Acetyl-hydrazino)-benzenesulfonamide DMHYKR8 MI TTANPDJ DMHYKR8 MN Carbonic anhydrase II (CA-II) DMHYKR8 MT DTT DMHYKR8 MA Inhibitor DMHYKR8 RN Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/membrane-associated carbonic anhydrase isozymes I, II, and IX with sulfonamide... J Med Chem. 2005 Mar 24;48(6):2121-5. DMHYKR8 RU https://pubmed.ncbi.nlm.nih.gov/15771455 DMHYKR8 DI DMHYKR8 DMHYKR8 DN 2-(N''-Acetyl-hydrazino)-benzenesulfonamide DMHYKR8 MI TT2LVK8 DMHYKR8 MN Carbonic anhydrase IX (CA-IX) DMHYKR8 MT DTT DMHYKR8 MA Inhibitor DMHYKR8 RN Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/membrane-associated carbonic anhydrase isozymes I, II, and IX with sulfonamide... J Med Chem. 2005 Mar 24;48(6):2121-5. DMHYKR8 RU https://pubmed.ncbi.nlm.nih.gov/15771455 DMKY71Z DI DMKY71Z DMKY71Z DN 2-(naphthalen-2-yl)-4,5-dihydro-1H-imidazole DMKY71Z MI TT3WG5C DMKY71Z MN Monoamine oxidase type A (MAO-A) DMKY71Z MT DTT DMKY71Z MA Inhibitor DMKY71Z RN Ultrasound promoted synthesis of 2-imidazolines in water: a greener approach toward monoamine oxidase inhibitors. Bioorg Med Chem Lett. 2009 Jan 15;19(2):546-9. DMKY71Z RU https://pubmed.ncbi.nlm.nih.gov/19064321 DMKY71Z DI DMKY71Z DMKY71Z DN 2-(naphthalen-2-yl)-4,5-dihydro-1H-imidazole DMKY71Z MI TTGP7BY DMKY71Z MN Monoamine oxidase type B (MAO-B) DMKY71Z MT DTT DMKY71Z MA Inhibitor DMKY71Z RN Ultrasound promoted synthesis of 2-imidazolines in water: a greener approach toward monoamine oxidase inhibitors. Bioorg Med Chem Lett. 2009 Jan 15;19(2):546-9. DMKY71Z RU https://pubmed.ncbi.nlm.nih.gov/19064321 DMEXBUF DI DMEXBUF DMEXBUF DN 2-(naphthalen-2-ylsulfonyl)naphthalene-1,4-diol DMEXBUF MI TTRVTMX DMEXBUF MN Bacterial Beta-ketoacyl-ACP synthase III (Bact fabH) DMEXBUF MT DTT DMEXBUF MA Inhibitor DMEXBUF RN Synthesis and biological evaluation of novel sulfonyl-naphthalene-1,4-diols as FabH inhibitors. Bioorg Med Chem Lett. 2008 Dec 15;18(24):6402-5. DMEXBUF RU https://pubmed.ncbi.nlm.nih.gov/18996691 DML4GHA DI DML4GHA DML4GHA DN 2-(N-Cyclopentylamino)-3'-bromopropiophenone DML4GHA MI TTVBI8W DML4GHA MN Dopamine transporter (DAT) DML4GHA MT DTT DML4GHA MA Inhibitor DML4GHA RN Synthesis and biological evaluation of bupropion analogues as potential pharmacotherapies for smoking cessation. J Med Chem. 2010 Mar 11;53(5):2204-14. DML4GHA RU https://pubmed.ncbi.nlm.nih.gov/20158204 DML4GHA DI DML4GHA DML4GHA DN 2-(N-Cyclopentylamino)-3'-bromopropiophenone DML4GHA MI TTAWNKZ DML4GHA MN Norepinephrine transporter (NET) DML4GHA MT DTT DML4GHA MA Inhibitor DML4GHA RN Synthesis and biological evaluation of bupropion analogues as potential pharmacotherapies for smoking cessation. J Med Chem. 2010 Mar 11;53(5):2204-14. DML4GHA RU https://pubmed.ncbi.nlm.nih.gov/20158204 DMP68CE DI DMP68CE DMP68CE DN 2-(N-Cyclopentylamino)-3'-chloropropiophenone DMP68CE MI TTVBI8W DMP68CE MN Dopamine transporter (DAT) DMP68CE MT DTT DMP68CE MA Inhibitor DMP68CE RN Synthesis and biological evaluation of bupropion analogues as potential pharmacotherapies for cocaine addiction. J Med Chem. 2009 Nov 12;52(21):6768-81. DMP68CE RU https://pubmed.ncbi.nlm.nih.gov/19821577 DMP68CE DI DMP68CE DMP68CE DN 2-(N-Cyclopentylamino)-3'-chloropropiophenone DMP68CE MI TTAWNKZ DMP68CE MN Norepinephrine transporter (NET) DMP68CE MT DTT DMP68CE MA Inhibitor DMP68CE RN Synthesis and biological evaluation of bupropion analogues as potential pharmacotherapies for cocaine addiction. J Med Chem. 2009 Nov 12;52(21):6768-81. DMP68CE RU https://pubmed.ncbi.nlm.nih.gov/19821577 DMH6FKX DI DMH6FKX DMH6FKX DN 2-(N-Cyclopentylamino)-3'-fluoropropiophenone DMH6FKX MI TTVBI8W DMH6FKX MN Dopamine transporter (DAT) DMH6FKX MT DTT DMH6FKX MA Inhibitor DMH6FKX RN Synthesis and biological evaluation of bupropion analogues as potential pharmacotherapies for smoking cessation. J Med Chem. 2010 Mar 11;53(5):2204-14. DMH6FKX RU https://pubmed.ncbi.nlm.nih.gov/20158204 DMH6FKX DI DMH6FKX DMH6FKX DN 2-(N-Cyclopentylamino)-3'-fluoropropiophenone DMH6FKX MI TTAWNKZ DMH6FKX MN Norepinephrine transporter (NET) DMH6FKX MT DTT DMH6FKX MA Inhibitor DMH6FKX RN Synthesis and biological evaluation of bupropion analogues as potential pharmacotherapies for smoking cessation. J Med Chem. 2010 Mar 11;53(5):2204-14. DMH6FKX RU https://pubmed.ncbi.nlm.nih.gov/20158204 DMVN1UI DI DMVN1UI DMVN1UI DN 2-(N-Cyclopentylamino)-3'-methoxypropiophenone DMVN1UI MI TTVBI8W DMVN1UI MN Dopamine transporter (DAT) DMVN1UI MT DTT DMVN1UI MA Inhibitor DMVN1UI RN Synthesis and biological evaluation of bupropion analogues as potential pharmacotherapies for smoking cessation. J Med Chem. 2010 Mar 11;53(5):2204-14. DMVN1UI RU https://pubmed.ncbi.nlm.nih.gov/20158204 DMVN1UI DI DMVN1UI DMVN1UI DN 2-(N-Cyclopentylamino)-3'-methoxypropiophenone DMVN1UI MI TTAWNKZ DMVN1UI MN Norepinephrine transporter (NET) DMVN1UI MT DTT DMVN1UI MA Inhibitor DMVN1UI RN Synthesis and biological evaluation of bupropion analogues as potential pharmacotherapies for smoking cessation. J Med Chem. 2010 Mar 11;53(5):2204-14. DMVN1UI RU https://pubmed.ncbi.nlm.nih.gov/20158204 DMVN1UI DI DMVN1UI DMVN1UI DN 2-(N-Cyclopentylamino)-3'-methoxypropiophenone DMVN1UI MI TT3ROYC DMVN1UI MN Serotonin transporter (SERT) DMVN1UI MT DTT DMVN1UI MA Inhibitor DMVN1UI RN Synthesis and biological evaluation of bupropion analogues as potential pharmacotherapies for smoking cessation. J Med Chem. 2010 Mar 11;53(5):2204-14. DMVN1UI RU https://pubmed.ncbi.nlm.nih.gov/20158204 DMG87RK DI DMG87RK DMG87RK DN 2-(N-Cyclopentylamino)-3'-methylpropiophenone DMG87RK MI TTVBI8W DMG87RK MN Dopamine transporter (DAT) DMG87RK MT DTT DMG87RK MA Inhibitor DMG87RK RN Synthesis and biological evaluation of bupropion analogues as potential pharmacotherapies for smoking cessation. J Med Chem. 2010 Mar 11;53(5):2204-14. DMG87RK RU https://pubmed.ncbi.nlm.nih.gov/20158204 DMG87RK DI DMG87RK DMG87RK DN 2-(N-Cyclopentylamino)-3'-methylpropiophenone DMG87RK MI TTAWNKZ DMG87RK MN Norepinephrine transporter (NET) DMG87RK MT DTT DMG87RK MA Inhibitor DMG87RK RN Synthesis and biological evaluation of bupropion analogues as potential pharmacotherapies for smoking cessation. J Med Chem. 2010 Mar 11;53(5):2204-14. DMG87RK RU https://pubmed.ncbi.nlm.nih.gov/20158204 DMNMES3 DI DMNMES3 DMNMES3 DN 2-(N-Cyclopropylamino)-3-chloropropiophenone DMNMES3 MI TTVBI8W DMNMES3 MN Dopamine transporter (DAT) DMNMES3 MT DTT DMNMES3 MA Inhibitor DMNMES3 RN Synthesis and biological evaluation of bupropion analogues as potential pharmacotherapies for cocaine addiction. J Med Chem. 2009 Nov 12;52(21):6768-81. DMNMES3 RU https://pubmed.ncbi.nlm.nih.gov/19821577 DMNMES3 DI DMNMES3 DMNMES3 DN 2-(N-Cyclopropylamino)-3-chloropropiophenone DMNMES3 MI TTAWNKZ DMNMES3 MN Norepinephrine transporter (NET) DMNMES3 MT DTT DMNMES3 MA Inhibitor DMNMES3 RN Synthesis and biological evaluation of bupropion analogues as potential pharmacotherapies for cocaine addiction. J Med Chem. 2009 Nov 12;52(21):6768-81. DMNMES3 RU https://pubmed.ncbi.nlm.nih.gov/19821577 DMNMES3 DI DMNMES3 DMNMES3 DN 2-(N-Cyclopropylamino)-3-chloropropiophenone DMNMES3 MI TT3ROYC DMNMES3 MN Serotonin transporter (SERT) DMNMES3 MT DTT DMNMES3 MA Inhibitor DMNMES3 RN Synthesis and biological evaluation of bupropion analogues as potential pharmacotherapies for cocaine addiction. J Med Chem. 2009 Nov 12;52(21):6768-81. DMNMES3 RU https://pubmed.ncbi.nlm.nih.gov/19821577 DMCK7SV DI DMCK7SV DMCK7SV DN 2-(N-Isopropylamino)-3'-chloropropiophenone DMCK7SV MI TTVBI8W DMCK7SV MN Dopamine transporter (DAT) DMCK7SV MT DTT DMCK7SV MA Inhibitor DMCK7SV RN Synthesis and biological evaluation of bupropion analogues as potential pharmacotherapies for cocaine addiction. J Med Chem. 2009 Nov 12;52(21):6768-81. DMCK7SV RU https://pubmed.ncbi.nlm.nih.gov/19821577 DMZVHSB DI DMZVHSB DMZVHSB DN 2-(N-Morpholino)-Ethanesulfonic Acid DMZVHSB MI TT1RS9F DMZVHSB MN Acetylcholinesterase (AChE) DMZVHSB MT DTT DMZVHSB MA Inhibitor DMZVHSB RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMZVHSB RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMZVHSB DI DMZVHSB DMZVHSB DN 2-(N-Morpholino)-Ethanesulfonic Acid DMZVHSB MI TTNAW8S DMZVHSB MN Bacterial Flavohemoglobin (Bact hmp) DMZVHSB MT DTT DMZVHSB MA Inhibitor DMZVHSB RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMZVHSB RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMZVHSB DI DMZVHSB DMZVHSB DN 2-(N-Morpholino)-Ethanesulfonic Acid DMZVHSB MI TTC67I0 DMZVHSB MN Bacterial Glucosamine-6-phosphate synthase (Bact glmS) DMZVHSB MT DTT DMZVHSB MA Inhibitor DMZVHSB RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMZVHSB RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMZVHSB DI DMZVHSB DMZVHSB DN 2-(N-Morpholino)-Ethanesulfonic Acid DMZVHSB MI TTEB0GD DMZVHSB MN Cholinesterase (BCHE) DMZVHSB MT DTT DMZVHSB MA Inhibitor DMZVHSB RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMZVHSB RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMZVHSB DI DMZVHSB DMZVHSB DN 2-(N-Morpholino)-Ethanesulfonic Acid DMZVHSB MI TT8VUE0 DMZVHSB MN Chymase (CYM) DMZVHSB MT DTT DMZVHSB MA Inhibitor DMZVHSB RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMZVHSB RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMZVHSB DI DMZVHSB DMZVHSB DN 2-(N-Morpholino)-Ethanesulfonic Acid DMZVHSB MI TTN7BL9 DMZVHSB MN Corticosteroid 11-beta-dehydrogenase 1 (HSD11B1) DMZVHSB MT DTT DMZVHSB MA Inhibitor DMZVHSB RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMZVHSB RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMZVHSB DI DMZVHSB DMZVHSB DN 2-(N-Morpholino)-Ethanesulfonic Acid DMZVHSB MI TT9SL3Q DMZVHSB MN Polypeptide deformylase (PDF) DMZVHSB MT DTT DMZVHSB MA Inhibitor DMZVHSB RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMZVHSB RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMZVHSB DI DMZVHSB DMZVHSB DN 2-(N-Morpholino)-Ethanesulfonic Acid DMZVHSB MI TTHI19T DMZVHSB MN Staphylococcus Beta-lactamase (Stap-coc blaZ) DMZVHSB MT DTT DMZVHSB MA Inhibitor DMZVHSB RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMZVHSB RU https://pubmed.ncbi.nlm.nih.gov/17139284 DM85ZCW DI DM85ZCW DM85ZCW DN 2-(N-Pyrrolidinyl)-3'-bromopropiophenone DM85ZCW MI TTVBI8W DM85ZCW MN Dopamine transporter (DAT) DM85ZCW MT DTT DM85ZCW MA Inhibitor DM85ZCW RN Synthesis and biological evaluation of bupropion analogues as potential pharmacotherapies for smoking cessation. J Med Chem. 2010 Mar 11;53(5):2204-14. DM85ZCW RU https://pubmed.ncbi.nlm.nih.gov/20158204 DM85ZCW DI DM85ZCW DM85ZCW DN 2-(N-Pyrrolidinyl)-3'-bromopropiophenone DM85ZCW MI TTAWNKZ DM85ZCW MN Norepinephrine transporter (NET) DM85ZCW MT DTT DM85ZCW MA Inhibitor DM85ZCW RN Synthesis and biological evaluation of bupropion analogues as potential pharmacotherapies for smoking cessation. J Med Chem. 2010 Mar 11;53(5):2204-14. DM85ZCW RU https://pubmed.ncbi.nlm.nih.gov/20158204 DMYPOC5 DI DMYPOC5 DMYPOC5 DN 2-(N-Pyrrolidinyl)-3'-fluoropropiophenone DMYPOC5 MI TTVBI8W DMYPOC5 MN Dopamine transporter (DAT) DMYPOC5 MT DTT DMYPOC5 MA Inhibitor DMYPOC5 RN Synthesis and biological evaluation of bupropion analogues as potential pharmacotherapies for smoking cessation. J Med Chem. 2010 Mar 11;53(5):2204-14. DMYPOC5 RU https://pubmed.ncbi.nlm.nih.gov/20158204 DMYPOC5 DI DMYPOC5 DMYPOC5 DN 2-(N-Pyrrolidinyl)-3'-fluoropropiophenone DMYPOC5 MI TTAWNKZ DMYPOC5 MN Norepinephrine transporter (NET) DMYPOC5 MT DTT DMYPOC5 MA Inhibitor DMYPOC5 RN Synthesis and biological evaluation of bupropion analogues as potential pharmacotherapies for smoking cessation. J Med Chem. 2010 Mar 11;53(5):2204-14. DMYPOC5 RU https://pubmed.ncbi.nlm.nih.gov/20158204 DM1W3L9 DI DM1W3L9 DM1W3L9 DN 2-(N-Pyrrolidinyl)-3'-methoxypropiophenone DM1W3L9 MI TTVBI8W DM1W3L9 MN Dopamine transporter (DAT) DM1W3L9 MT DTT DM1W3L9 MA Inhibitor DM1W3L9 RN Synthesis and biological evaluation of bupropion analogues as potential pharmacotherapies for smoking cessation. J Med Chem. 2010 Mar 11;53(5):2204-14. DM1W3L9 RU https://pubmed.ncbi.nlm.nih.gov/20158204 DM1W3L9 DI DM1W3L9 DM1W3L9 DN 2-(N-Pyrrolidinyl)-3'-methoxypropiophenone DM1W3L9 MI TTAWNKZ DM1W3L9 MN Norepinephrine transporter (NET) DM1W3L9 MT DTT DM1W3L9 MA Inhibitor DM1W3L9 RN Synthesis and biological evaluation of bupropion analogues as potential pharmacotherapies for smoking cessation. J Med Chem. 2010 Mar 11;53(5):2204-14. DM1W3L9 RU https://pubmed.ncbi.nlm.nih.gov/20158204 DMGKXOI DI DMGKXOI DMGKXOI DN 2-(N-Pyrrolidinyl)-3'-methylpropiophenone DMGKXOI MI TTVBI8W DMGKXOI MN Dopamine transporter (DAT) DMGKXOI MT DTT DMGKXOI MA Inhibitor DMGKXOI RN Synthesis and biological evaluation of bupropion analogues as potential pharmacotherapies for smoking cessation. J Med Chem. 2010 Mar 11;53(5):2204-14. DMGKXOI RU https://pubmed.ncbi.nlm.nih.gov/20158204 DMGKXOI DI DMGKXOI DMGKXOI DN 2-(N-Pyrrolidinyl)-3'-methylpropiophenone DMGKXOI MI TTAWNKZ DMGKXOI MN Norepinephrine transporter (NET) DMGKXOI MT DTT DMGKXOI MA Inhibitor DMGKXOI RN Synthesis and biological evaluation of bupropion analogues as potential pharmacotherapies for smoking cessation. J Med Chem. 2010 Mar 11;53(5):2204-14. DMGKXOI RU https://pubmed.ncbi.nlm.nih.gov/20158204 DM1I9LQ DI DM1I9LQ DM1I9LQ DN 2-(N-Pyrrolidinyl)-3'-nitropropiophenone DM1I9LQ MI TTVBI8W DM1I9LQ MN Dopamine transporter (DAT) DM1I9LQ MT DTT DM1I9LQ MA Inhibitor DM1I9LQ RN Synthesis and biological evaluation of bupropion analogues as potential pharmacotherapies for smoking cessation. J Med Chem. 2010 Mar 11;53(5):2204-14. DM1I9LQ RU https://pubmed.ncbi.nlm.nih.gov/20158204 DM1I9LQ DI DM1I9LQ DM1I9LQ DN 2-(N-Pyrrolidinyl)-3'-nitropropiophenone DM1I9LQ MI TTAWNKZ DM1I9LQ MN Norepinephrine transporter (NET) DM1I9LQ MT DTT DM1I9LQ MA Inhibitor DM1I9LQ RN Synthesis and biological evaluation of bupropion analogues as potential pharmacotherapies for smoking cessation. J Med Chem. 2010 Mar 11;53(5):2204-14. DM1I9LQ RU https://pubmed.ncbi.nlm.nih.gov/20158204 DMKIEVP DI DMKIEVP DMKIEVP DN 2-(N-tert-Butylamino)-3',4'-dichloropropiophenone DMKIEVP MI TTVBI8W DMKIEVP MN Dopamine transporter (DAT) DMKIEVP MT DTT DMKIEVP MA Inhibitor DMKIEVP RN Synthesis and biological evaluation of bupropion analogues as potential pharmacotherapies for cocaine addiction. J Med Chem. 2009 Nov 12;52(21):6768-81. DMKIEVP RU https://pubmed.ncbi.nlm.nih.gov/19821577 DMKIEVP DI DMKIEVP DMKIEVP DN 2-(N-tert-Butylamino)-3',4'-dichloropropiophenone DMKIEVP MI TTAWNKZ DMKIEVP MN Norepinephrine transporter (NET) DMKIEVP MT DTT DMKIEVP MA Inhibitor DMKIEVP RN Synthesis and biological evaluation of bupropion analogues as potential pharmacotherapies for cocaine addiction. J Med Chem. 2009 Nov 12;52(21):6768-81. DMKIEVP RU https://pubmed.ncbi.nlm.nih.gov/19821577 DMKIEVP DI DMKIEVP DMKIEVP DN 2-(N-tert-Butylamino)-3',4'-dichloropropiophenone DMKIEVP MI TT3ROYC DMKIEVP MN Serotonin transporter (SERT) DMKIEVP MT DTT DMKIEVP MA Inhibitor DMKIEVP RN Synthesis and biological evaluation of bupropion analogues as potential pharmacotherapies for cocaine addiction. J Med Chem. 2009 Nov 12;52(21):6768-81. DMKIEVP RU https://pubmed.ncbi.nlm.nih.gov/19821577 DMY2PBO DI DMY2PBO DMY2PBO DN 2-(N-tert-Butylamino)-3'-chloroheptanophenone DMY2PBO MI TTVBI8W DMY2PBO MN Dopamine transporter (DAT) DMY2PBO MT DTT DMY2PBO MA Inhibitor DMY2PBO RN Synthesis and biological evaluation of bupropion analogues as potential pharmacotherapies for cocaine addiction. J Med Chem. 2009 Nov 12;52(21):6768-81. DMY2PBO RU https://pubmed.ncbi.nlm.nih.gov/19821577 DMY2PBO DI DMY2PBO DMY2PBO DN 2-(N-tert-Butylamino)-3'-chloroheptanophenone DMY2PBO MI TTAWNKZ DMY2PBO MN Norepinephrine transporter (NET) DMY2PBO MT DTT DMY2PBO MA Inhibitor DMY2PBO RN Synthesis and biological evaluation of bupropion analogues as potential pharmacotherapies for cocaine addiction. J Med Chem. 2009 Nov 12;52(21):6768-81. DMY2PBO RU https://pubmed.ncbi.nlm.nih.gov/19821577 DMPO3CJ DI DMPO3CJ DMPO3CJ DN 2-(N-tert-Butylamino)-3'-chlorohexanophenone DMPO3CJ MI TTVBI8W DMPO3CJ MN Dopamine transporter (DAT) DMPO3CJ MT DTT DMPO3CJ MA Inhibitor DMPO3CJ RN Synthesis and biological evaluation of bupropion analogues as potential pharmacotherapies for cocaine addiction. J Med Chem. 2009 Nov 12;52(21):6768-81. DMPO3CJ RU https://pubmed.ncbi.nlm.nih.gov/19821577 DMPO3CJ DI DMPO3CJ DMPO3CJ DN 2-(N-tert-Butylamino)-3'-chlorohexanophenone DMPO3CJ MI TTAWNKZ DMPO3CJ MN Norepinephrine transporter (NET) DMPO3CJ MT DTT DMPO3CJ MA Inhibitor DMPO3CJ RN Synthesis and biological evaluation of bupropion analogues as potential pharmacotherapies for cocaine addiction. J Med Chem. 2009 Nov 12;52(21):6768-81. DMPO3CJ RU https://pubmed.ncbi.nlm.nih.gov/19821577 DMW47VA DI DMW47VA DMW47VA DN 2-(N-tert-Butylamino)-3'-chlorooctanophenone DMW47VA MI TTVBI8W DMW47VA MN Dopamine transporter (DAT) DMW47VA MT DTT DMW47VA MA Inhibitor DMW47VA RN Synthesis and biological evaluation of bupropion analogues as potential pharmacotherapies for cocaine addiction. J Med Chem. 2009 Nov 12;52(21):6768-81. DMW47VA RU https://pubmed.ncbi.nlm.nih.gov/19821577 DMW47VA DI DMW47VA DMW47VA DN 2-(N-tert-Butylamino)-3'-chlorooctanophenone DMW47VA MI TTAWNKZ DMW47VA MN Norepinephrine transporter (NET) DMW47VA MT DTT DMW47VA MA Inhibitor DMW47VA RN Synthesis and biological evaluation of bupropion analogues as potential pharmacotherapies for cocaine addiction. J Med Chem. 2009 Nov 12;52(21):6768-81. DMW47VA RU https://pubmed.ncbi.nlm.nih.gov/19821577 DMTZ540 DI DMTZ540 DMTZ540 DN 2-(N-tert-Butylamino)-3'-chloropentanophenone DMTZ540 MI TTVBI8W DMTZ540 MN Dopamine transporter (DAT) DMTZ540 MT DTT DMTZ540 MA Inhibitor DMTZ540 RN Synthesis and biological evaluation of bupropion analogues as potential pharmacotherapies for cocaine addiction. J Med Chem. 2009 Nov 12;52(21):6768-81. DMTZ540 RU https://pubmed.ncbi.nlm.nih.gov/19821577 DMTZ540 DI DMTZ540 DMTZ540 DN 2-(N-tert-Butylamino)-3'-chloropentanophenone DMTZ540 MI TTAWNKZ DMTZ540 MN Norepinephrine transporter (NET) DMTZ540 MT DTT DMTZ540 MA Inhibitor DMTZ540 RN Synthesis and biological evaluation of bupropion analogues as potential pharmacotherapies for cocaine addiction. J Med Chem. 2009 Nov 12;52(21):6768-81. DMTZ540 RU https://pubmed.ncbi.nlm.nih.gov/19821577 DME1SP4 DI DME1SP4 DME1SP4 DN 2-(N-tert-Butylamino)-4'-chloropropiophenone DME1SP4 MI TTVBI8W DME1SP4 MN Dopamine transporter (DAT) DME1SP4 MT DTT DME1SP4 MA Inhibitor DME1SP4 RN Synthesis and biological evaluation of bupropion analogues as potential pharmacotherapies for cocaine addiction. J Med Chem. 2009 Nov 12;52(21):6768-81. DME1SP4 RU https://pubmed.ncbi.nlm.nih.gov/19821577 DM9E5LT DI DM9E5LT DM9E5LT DN 2-(N-tert-Butylamino)propiophenone DM9E5LT MI TTVBI8W DM9E5LT MN Dopamine transporter (DAT) DM9E5LT MT DTT DM9E5LT MA Inhibitor DM9E5LT RN Synthesis and biological evaluation of bupropion analogues as potential pharmacotherapies for cocaine addiction. J Med Chem. 2009 Nov 12;52(21):6768-81. DM9E5LT RU https://pubmed.ncbi.nlm.nih.gov/19821577 DM9E5LT DI DM9E5LT DM9E5LT DN 2-(N-tert-Butylamino)propiophenone DM9E5LT MI TTAWNKZ DM9E5LT MN Norepinephrine transporter (NET) DM9E5LT MT DTT DM9E5LT MA Inhibitor DM9E5LT RN Synthesis and biological evaluation of bupropion analogues as potential pharmacotherapies for cocaine addiction. J Med Chem. 2009 Nov 12;52(21):6768-81. DM9E5LT RU https://pubmed.ncbi.nlm.nih.gov/19821577 DM3RCA9 DI DM3RCA9 DM3RCA9 DN 2-(o-toluidino)-5-ethylthiazol-4(5H)-one DM3RCA9 MI TTN7BL9 DM3RCA9 MN Corticosteroid 11-beta-dehydrogenase 1 (HSD11B1) DM3RCA9 MT DTT DM3RCA9 MA Inhibitor DM3RCA9 RN 2-amino-1,3-thiazol-4(5H)-ones as potent and selective 11beta-hydroxysteroid dehydrogenase type 1 inhibitors: enzyme-ligand co-crystal structure an... J Med Chem. 2008 May 22;51(10):2933-43. DM3RCA9 RU https://pubmed.ncbi.nlm.nih.gov/18419108 DMYTJX4 DI DMYTJX4 DMYTJX4 DN 2-(o-toluidino)-5-isopropylthiazol-4(5H)-one DMYTJX4 MI TTN7BL9 DMYTJX4 MN Corticosteroid 11-beta-dehydrogenase 1 (HSD11B1) DMYTJX4 MT DTT DMYTJX4 MA Inhibitor DMYTJX4 RN The discovery of 2-anilinothiazolones as 11beta-HSD1 inhibitors. Bioorg Med Chem Lett. 2007 Nov 15;17(22):6056-61. DMYTJX4 RU https://pubmed.ncbi.nlm.nih.gov/17919905 DM7LOHK DI DM7LOHK DM7LOHK DN 2-(Oxalyl-Amino)-Benzoic Acid DM7LOHK MI TTELIN2 DM7LOHK MN PTPN1 messenger RNA (PTPN1 mRNA) DM7LOHK MT DTT DM7LOHK MA Inhibitor DM7LOHK RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DM7LOHK RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMPUARE DI DMPUARE DMPUARE DN 2-(Phenylamino)-6-(3-acetamidophenyl)pyrazine DMPUARE MI TT0EOB8 DMPUARE MN B-Raf messenger RNA (BRAF mRNA) DMPUARE MT DTT DMPUARE MA Inhibitor DMPUARE RN Novel inhibitors of B-RAF based on a disubstituted pyrazine scaffold. Generation of a nanomolar lead. J Med Chem. 2006 Jan 12;49(1):407-16. DMPUARE RU https://pubmed.ncbi.nlm.nih.gov/16392826 DMRIFCW DI DMRIFCW DMRIFCW DN 2-(phenylethynyl)pyrimidine DMRIFCW MI TTHS256 DMRIFCW MN Metabotropic glutamate receptor 5 (mGluR5) DMRIFCW MT DTT DMRIFCW MA Inhibitor DMRIFCW RN Discovery of molecular switches that modulate modes of metabotropic glutamate receptor subtype 5 (mGlu5) pharmacology in vitro and in vivo within a... J Med Chem. 2009 Jul 23;52(14):4103-6. DMRIFCW RU https://pubmed.ncbi.nlm.nih.gov/19537763 DMFBTM2 DI DMFBTM2 DMFBTM2 DN 2-(phenylsulfonamido)-1-naphthoic acid DMFBTM2 MI TTZL0OI DMFBTM2 MN Methionine aminopeptidase 2 (METAP2) DMFBTM2 MT DTT DMFBTM2 MA Inhibitor DMFBTM2 RN Development of sulfonamide compounds as potent methionine aminopeptidase type II inhibitors with antiproliferative properties. Bioorg Med Chem Lett. 2006 Jul 1;16(13):3574-7. DMFBTM2 RU https://pubmed.ncbi.nlm.nih.gov/16632353 DMDGAHO DI DMDGAHO DMDGAHO DN 2-(phenylsulfonamido)-5-propylbenzoic acid DMDGAHO MI TTZL0OI DMDGAHO MN Methionine aminopeptidase 2 (METAP2) DMDGAHO MT DTT DMDGAHO MA Inhibitor DMDGAHO RN Development of sulfonamide compounds as potent methionine aminopeptidase type II inhibitors with antiproliferative properties. Bioorg Med Chem Lett. 2006 Jul 1;16(13):3574-7. DMDGAHO RU https://pubmed.ncbi.nlm.nih.gov/16632353 DMMSI67 DI DMMSI67 DMMSI67 DN 2-(Phenylsulfonamido)acetic Acid DMMSI67 MI TTFBNVI DMMSI67 MN Aldose reductase (AKR1B1) DMMSI67 MT DTT DMMSI67 MA Inhibitor DMMSI67 RN A diverse series of substituted benzenesulfonamides as aldose reductase inhibitors with antioxidant activity: design, synthesis, and in vitro activ... J Med Chem. 2010 Nov 11;53(21):7756-66. DMMSI67 RU https://pubmed.ncbi.nlm.nih.gov/20936791 DMCF75U DI DMCF75U DMCF75U DN 2-(phenylsulfonyl)-1-(thiophen-3-yl)ethanone DMCF75U MI TTN7BL9 DMCF75U MN Corticosteroid 11-beta-dehydrogenase 1 (HSD11B1) DMCF75U MT DTT DMCF75U MA Inhibitor DMCF75U RN beta-Keto sulfones as inhibitors of 11beta-hydroxysteroid dehydrogenase type I and the mechanism of action. Bioorg Med Chem. 2007 Jul 1;15(13):4396-405. DMCF75U RU https://pubmed.ncbi.nlm.nih.gov/17490884 DM93XJT DI DM93XJT DM93XJT DN 2-(phenylsulfonyl)-1-p-tolylethanone DM93XJT MI TTN7BL9 DM93XJT MN Corticosteroid 11-beta-dehydrogenase 1 (HSD11B1) DM93XJT MT DTT DM93XJT MA Inhibitor DM93XJT RN beta-Keto sulfones as inhibitors of 11beta-hydroxysteroid dehydrogenase type I and the mechanism of action. Bioorg Med Chem. 2007 Jul 1;15(13):4396-405. DM93XJT RU https://pubmed.ncbi.nlm.nih.gov/17490884 DMAKR2E DI DMAKR2E DMAKR2E DN 2-(phenylsulfonyl)naphthalene-1,4-diol DMAKR2E MI TTRVTMX DMAKR2E MN Bacterial Beta-ketoacyl-ACP synthase III (Bact fabH) DMAKR2E MT DTT DMAKR2E MA Inhibitor DMAKR2E RN Synthesis and biological evaluation of novel sulfonyl-naphthalene-1,4-diols as FabH inhibitors. Bioorg Med Chem Lett. 2008 Dec 15;18(24):6402-5. DMAKR2E RU https://pubmed.ncbi.nlm.nih.gov/18996691 DM4V2ZO DI DM4V2ZO DM4V2ZO DN 2-(Phosphonooxy)Butanoic Acid DM4V2ZO MI TTVNA43 DM4V2ZO MN Bacterial Deoxy-D-manno-octulosonate 8-phosphate synthase (Bact kdsA) DM4V2ZO MT DTT DM4V2ZO MA Inhibitor DM4V2ZO RN DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Nucleic Acids Res. 2011 Jan;39(Database issue):D1035-41. DM4V2ZO RU https://pubmed.ncbi.nlm.nih.gov/21059682 DML6HSE DI DML6HSE DML6HSE DN 2-(piperazin-1-yl)-5,6,7,8-tetrahydroquinoline DML6HSE MI TTJQOD7 DML6HSE MN 5-HT 2A receptor (HTR2A) DML6HSE MT DTT DML6HSE MA Inhibitor DML6HSE RN Design and synthesis of orally-active and selective azaindane 5HT2c agonist for the treatment of obesity. Bioorg Med Chem Lett. 2010 Jan 1;20(1):266-71. DML6HSE RU https://pubmed.ncbi.nlm.nih.gov/19914063 DML6HSE DI DML6HSE DML6HSE DN 2-(piperazin-1-yl)-5,6,7,8-tetrahydroquinoline DML6HSE MI TTWJBZ5 DML6HSE MN 5-HT 2C receptor (HTR2C) DML6HSE MT DTT DML6HSE MA Inhibitor DML6HSE RN Design and synthesis of orally-active and selective azaindane 5HT2c agonist for the treatment of obesity. Bioorg Med Chem Lett. 2010 Jan 1;20(1):266-71. DML6HSE RU https://pubmed.ncbi.nlm.nih.gov/19914063 DMGQX1I DI DMGQX1I DMGQX1I DN 2-(piperidin-1-yl)-4H-benzo[h]chromen-4-one DMGQX1I MI TTK3PY9 DMGQX1I MN DNA-dependent protein kinase catalytic (PRKDC) DMGQX1I MT DTT DMGQX1I MA Inhibitor DMGQX1I RN Discovery of potent chromen-4-one inhibitors of the DNA-dependent protein kinase (DNA-PK) using a small-molecule library approach. J Med Chem. 2005 Dec 1;48(24):7829-46. DMGQX1I RU https://pubmed.ncbi.nlm.nih.gov/16302822 DMLT635 DI DMLT635 DMLT635 DN 2-(p-Methylsulfonylbenzoyl)furan DMLT635 MI TT8NGED DMLT635 MN Prostaglandin G/H synthase 1 (COX-1) DMLT635 MT DTT DMLT635 MA Inhibitor DMLT635 RN Synthesis, anti-inflammatory activity, and in vitro antitumor effect of a novel class of cyclooxygenase inhibitors: 4-(aryloyl)phenyl methyl sulfones. J Med Chem. 2010 Sep 23;53(18):6560-71. DMLT635 RU https://pubmed.ncbi.nlm.nih.gov/20804197 DMLT635 DI DMLT635 DMLT635 DN 2-(p-Methylsulfonylbenzoyl)furan DMLT635 MI TTVKILB DMLT635 MN Prostaglandin G/H synthase 2 (COX-2) DMLT635 MT DTT DMLT635 MA Inhibitor DMLT635 RN Synthesis, anti-inflammatory activity, and in vitro antitumor effect of a novel class of cyclooxygenase inhibitors: 4-(aryloyl)phenyl methyl sulfones. J Med Chem. 2010 Sep 23;53(18):6560-71. DMLT635 RU https://pubmed.ncbi.nlm.nih.gov/20804197 DM27YTF DI DM27YTF DM27YTF DN 2-(p-toluidino)-4-phenylpyrimidine-5-carbonitrile DM27YTF MI TTH6V3D DM27YTF MN Cyclin-dependent kinase 1 (CDK1) DM27YTF MT DTT DM27YTF MA Inhibitor DM27YTF RN 4-Aryl-5-cyano-2-aminopyrimidines as VEGF-R2 inhibitors: synthesis and biological evaluation. Bioorg Med Chem Lett. 2007 Jun 15;17(12):3266-70. DM27YTF RU https://pubmed.ncbi.nlm.nih.gov/17481894 DM27YTF DI DM27YTF DM27YTF DN 2-(p-toluidino)-4-phenylpyrimidine-5-carbonitrile DM27YTF MI TTUTJGQ DM27YTF MN Vascular endothelial growth factor receptor 2 (KDR) DM27YTF MT DTT DM27YTF MA Inhibitor DM27YTF RN 4-Aryl-5-cyano-2-aminopyrimidines as VEGF-R2 inhibitors: synthesis and biological evaluation. Bioorg Med Chem Lett. 2007 Jun 15;17(12):3266-70. DM27YTF RU https://pubmed.ncbi.nlm.nih.gov/17481894 DMON1A5 DI DMON1A5 DMON1A5 DN 2-(p-tolylthio)naphthalene-1,4-dione DMON1A5 MI TTRVTMX DMON1A5 MN Bacterial Beta-ketoacyl-ACP synthase III (Bact fabH) DMON1A5 MT DTT DMON1A5 MA Inhibitor DMON1A5 RN Synthesis and biological evaluation of novel sulfonyl-naphthalene-1,4-diols as FabH inhibitors. Bioorg Med Chem Lett. 2008 Dec 15;18(24):6402-5. DMON1A5 RU https://pubmed.ncbi.nlm.nih.gov/18996691 DMST2LX DI DMST2LX DMST2LX DN 2-(pyridin-2-yl)-1H-benzo[d]imidazol-5-amine DMST2LX MI TTZL0OI DMST2LX MN Methionine aminopeptidase 2 (METAP2) DMST2LX MT DTT DMST2LX MA Inhibitor DMST2LX RN Subtype-selectivity of metal-dependent methionine aminopeptidase inhibitors, Bioorg. Med. Chem. Lett. 20(14):4038-4044 (2010). DMST2LX RU http://www.sciencedirect.com/science/article/pii/S0960894X10007468 DMRUTDY DI DMRUTDY DMRUTDY DN 2-(pyridin-2-yl)-1H-benzo[d]imidazole DMRUTDY MI TTZL0OI DMRUTDY MN Methionine aminopeptidase 2 (METAP2) DMRUTDY MT DTT DMRUTDY MA Inhibitor DMRUTDY RN Subtype-selectivity of metal-dependent methionine aminopeptidase inhibitors, Bioorg. Med. Chem. Lett. 20(14):4038-4044 (2010). DMRUTDY RU http://www.sciencedirect.com/science/article/pii/S0960894X10007468 DMHFGMQ DI DMHFGMQ DMHFGMQ DN 2-(pyridin-2-yl)-1H-imidazo[4,5-c]pyridine DMHFGMQ MI TTZL0OI DMHFGMQ MN Methionine aminopeptidase 2 (METAP2) DMHFGMQ MT DTT DMHFGMQ MA Inhibitor DMHFGMQ RN Subtype-selectivity of metal-dependent methionine aminopeptidase inhibitors, Bioorg. Med. Chem. Lett. 20(14):4038-4044 (2010). DMHFGMQ RU http://www.sciencedirect.com/science/article/pii/S0960894X10007468 DM3EBYD DI DM3EBYD DM3EBYD DN 2-(pyridin-2-yl)-4-(m-tolylthio)pyrimidine DM3EBYD MI TTHS256 DM3EBYD MN Metabotropic glutamate receptor 5 (mGluR5) DM3EBYD MT DTT DM3EBYD MA Inhibitor DM3EBYD RN Structure-activity relationship of thiopyrimidines as mGluR5 antagonists. Bioorg Med Chem Lett. 2006 May 1;16(9):2467-9. DM3EBYD RU https://pubmed.ncbi.nlm.nih.gov/16481165 DMET46L DI DMET46L DMET46L DN 2-(pyrimidin-4-ylamino)thiazole-5-carbonitrile DMET46L MI TTUTJGQ DMET46L MN Vascular endothelial growth factor receptor 2 (KDR) DMET46L MT DTT DMET46L MA Inhibitor DMET46L RN Potent 2-[(pyrimidin-4-yl)amine}-1,3-thiazole-5-carbonitrile-based inhibitors of VEGFR-2 (KDR) kinase. Bioorg Med Chem Lett. 2006 Mar 1;16(5):1146-50. DMET46L RU https://pubmed.ncbi.nlm.nih.gov/16368234 DM5CEG8 DI DM5CEG8 DM5CEG8 DN 2-(Sulfanylmethyl)phenylphosphonic acid DM5CEG8 MI TTHI19T DM5CEG8 MN Staphylococcus Beta-lactamase (Stap-coc blaZ) DM5CEG8 MT DTT DM5CEG8 MA Inhibitor DM5CEG8 RN Mercaptophosphonate compounds as broad-spectrum inhibitors of the metallo-beta-lactamases. J Med Chem. 2010 Jul 8;53(13):4862-76. DM5CEG8 RU https://pubmed.ncbi.nlm.nih.gov/20527888 DMI457Y DI DMI457Y DMI457Y DN 2-(tert-butylamino)-1-(3-chlorophenyl)butan-1-one DMI457Y MI TTVBI8W DMI457Y MN Dopamine transporter (DAT) DMI457Y MT DTT DMI457Y MA Inhibitor DMI457Y RN Synthesis and biological evaluation of bupropion analogues as potential pharmacotherapies for smoking cessation. J Med Chem. 2010 Mar 11;53(5):2204-14. DMI457Y RU https://pubmed.ncbi.nlm.nih.gov/20158204 DMI457Y DI DMI457Y DMI457Y DN 2-(tert-butylamino)-1-(3-chlorophenyl)butan-1-one DMI457Y MI TTAWNKZ DMI457Y MN Norepinephrine transporter (NET) DMI457Y MT DTT DMI457Y MA Inhibitor DMI457Y RN Synthesis and biological evaluation of bupropion analogues as potential pharmacotherapies for smoking cessation. J Med Chem. 2010 Mar 11;53(5):2204-14. DMI457Y RU https://pubmed.ncbi.nlm.nih.gov/20158204 DMI457Y DI DMI457Y DMI457Y DN 2-(tert-butylamino)-1-(3-chlorophenyl)butan-1-one DMI457Y MI TT3ROYC DMI457Y MN Serotonin transporter (SERT) DMI457Y MT DTT DMI457Y MA Inhibitor DMI457Y RN Synthesis and biological evaluation of bupropion analogues as potential pharmacotherapies for smoking cessation. J Med Chem. 2010 Mar 11;53(5):2204-14. DMI457Y RU https://pubmed.ncbi.nlm.nih.gov/20158204 DM6PV4W DI DM6PV4W DM6PV4W DN 2-(tert-butylamino)-1-m-tolylpropan-1-one DM6PV4W MI TTVBI8W DM6PV4W MN Dopamine transporter (DAT) DM6PV4W MT DTT DM6PV4W MA Inhibitor DM6PV4W RN Synthesis and biological evaluation of bupropion analogues as potential pharmacotherapies for smoking cessation. J Med Chem. 2010 Mar 11;53(5):2204-14. DM6PV4W RU https://pubmed.ncbi.nlm.nih.gov/20158204 DM6PV4W DI DM6PV4W DM6PV4W DN 2-(tert-butylamino)-1-m-tolylpropan-1-one DM6PV4W MI TTAWNKZ DM6PV4W MN Norepinephrine transporter (NET) DM6PV4W MT DTT DM6PV4W MA Inhibitor DM6PV4W RN Synthesis and biological evaluation of bupropion analogues as potential pharmacotherapies for smoking cessation. J Med Chem. 2010 Mar 11;53(5):2204-14. DM6PV4W RU https://pubmed.ncbi.nlm.nih.gov/20158204 DMYFQDT DI DMYFQDT DMYFQDT DN 2-(tert-butylamino)-1-p-tolylpropan-1-one DMYFQDT MI TTVBI8W DMYFQDT MN Dopamine transporter (DAT) DMYFQDT MT DTT DMYFQDT MA Inhibitor DMYFQDT RN Synthesis and biological evaluation of bupropion analogues as potential pharmacotherapies for smoking cessation. J Med Chem. 2010 Mar 11;53(5):2204-14. DMYFQDT RU https://pubmed.ncbi.nlm.nih.gov/20158204 DMYFQDT DI DMYFQDT DMYFQDT DN 2-(tert-butylamino)-1-p-tolylpropan-1-one DMYFQDT MI TTAWNKZ DMYFQDT MN Norepinephrine transporter (NET) DMYFQDT MT DTT DMYFQDT MA Inhibitor DMYFQDT RN Synthesis and biological evaluation of bupropion analogues as potential pharmacotherapies for smoking cessation. J Med Chem. 2010 Mar 11;53(5):2204-14. DMYFQDT RU https://pubmed.ncbi.nlm.nih.gov/20158204 DMOJK8Y DI DMOJK8Y DMOJK8Y DN 2-(tert-Butylamino)-3',4'-dichlorobutyrophenone DMOJK8Y MI TTVBI8W DMOJK8Y MN Dopamine transporter (DAT) DMOJK8Y MT DTT DMOJK8Y MA Inhibitor DMOJK8Y RN Synthesis and biological evaluation of bupropion analogues as potential pharmacotherapies for cocaine addiction. J Med Chem. 2009 Nov 12;52(21):6768-81. DMOJK8Y RU https://pubmed.ncbi.nlm.nih.gov/19821577 DMOJK8Y DI DMOJK8Y DMOJK8Y DN 2-(tert-Butylamino)-3',4'-dichlorobutyrophenone DMOJK8Y MI TTAWNKZ DMOJK8Y MN Norepinephrine transporter (NET) DMOJK8Y MT DTT DMOJK8Y MA Inhibitor DMOJK8Y RN Synthesis and biological evaluation of bupropion analogues as potential pharmacotherapies for cocaine addiction. J Med Chem. 2009 Nov 12;52(21):6768-81. DMOJK8Y RU https://pubmed.ncbi.nlm.nih.gov/19821577 DMOJK8Y DI DMOJK8Y DMOJK8Y DN 2-(tert-Butylamino)-3',4'-dichlorobutyrophenone DMOJK8Y MI TT3ROYC DMOJK8Y MN Serotonin transporter (SERT) DMOJK8Y MT DTT DMOJK8Y MA Inhibitor DMOJK8Y RN Synthesis and biological evaluation of bupropion analogues as potential pharmacotherapies for cocaine addiction. J Med Chem. 2009 Nov 12;52(21):6768-81. DMOJK8Y RU https://pubmed.ncbi.nlm.nih.gov/19821577 DMMUDQ7 DI DMMUDQ7 DMMUDQ7 DN 2-(tert-Butylamino)-3',4'-dichloropentanophenone DMMUDQ7 MI TTVBI8W DMMUDQ7 MN Dopamine transporter (DAT) DMMUDQ7 MT DTT DMMUDQ7 MA Inhibitor DMMUDQ7 RN Synthesis and biological evaluation of bupropion analogues as potential pharmacotherapies for cocaine addiction. J Med Chem. 2009 Nov 12;52(21):6768-81. DMMUDQ7 RU https://pubmed.ncbi.nlm.nih.gov/19821577 DMMUDQ7 DI DMMUDQ7 DMMUDQ7 DN 2-(tert-Butylamino)-3',4'-dichloropentanophenone DMMUDQ7 MI TTAWNKZ DMMUDQ7 MN Norepinephrine transporter (NET) DMMUDQ7 MT DTT DMMUDQ7 MA Inhibitor DMMUDQ7 RN Synthesis and biological evaluation of bupropion analogues as potential pharmacotherapies for cocaine addiction. J Med Chem. 2009 Nov 12;52(21):6768-81. DMMUDQ7 RU https://pubmed.ncbi.nlm.nih.gov/19821577 DMMUDQ7 DI DMMUDQ7 DMMUDQ7 DN 2-(tert-Butylamino)-3',4'-dichloropentanophenone DMMUDQ7 MI TT3ROYC DMMUDQ7 MN Serotonin transporter (SERT) DMMUDQ7 MT DTT DMMUDQ7 MA Inhibitor DMMUDQ7 RN Synthesis and biological evaluation of bupropion analogues as potential pharmacotherapies for cocaine addiction. J Med Chem. 2009 Nov 12;52(21):6768-81. DMMUDQ7 RU https://pubmed.ncbi.nlm.nih.gov/19821577 DMH3QLF DI DMH3QLF DMH3QLF DN 2-(tert-Butylamino)-3',5'-difluoropropiophenone DMH3QLF MI TTVBI8W DMH3QLF MN Dopamine transporter (DAT) DMH3QLF MT DTT DMH3QLF MA Inhibitor DMH3QLF RN Synthesis and biological evaluation of bupropion analogues as potential pharmacotherapies for cocaine addiction. J Med Chem. 2009 Nov 12;52(21):6768-81. DMH3QLF RU https://pubmed.ncbi.nlm.nih.gov/19821577 DM5YJP3 DI DM5YJP3 DM5YJP3 DN 2-(tert-Butylamino)-3'-fluoropropiophenone DM5YJP3 MI TTVBI8W DM5YJP3 MN Dopamine transporter (DAT) DM5YJP3 MT DTT DM5YJP3 MA Inhibitor DM5YJP3 RN Synthesis and biological evaluation of bupropion analogues as potential pharmacotherapies for cocaine addiction. J Med Chem. 2009 Nov 12;52(21):6768-81. DM5YJP3 RU https://pubmed.ncbi.nlm.nih.gov/19821577 DMH4IRP DI DMH4IRP DMH4IRP DN 2-(thiazol-4-yl)-1H-benzo[d]imidazol-5-amine DMH4IRP MI TTZL0OI DMH4IRP MN Methionine aminopeptidase 2 (METAP2) DMH4IRP MT DTT DMH4IRP MA Inhibitor DMH4IRP RN Subtype-selectivity of metal-dependent methionine aminopeptidase inhibitors, Bioorg. Med. Chem. Lett. 20(14):4038-4044 (2010). DMH4IRP RU http://www.sciencedirect.com/science/article/pii/S0960894X10007468 DMDL8KY DI DMDL8KY DMDL8KY DN 2-(trifluoromethoxy)-9H-carbazole DMDL8KY MI TTBGTCW DMDL8KY MN Kinesin spindle messenger RNA (KIF11 mRNA) DMDL8KY MT DTT DMDL8KY MA Inhibitor DMDL8KY RN Kinesin spindle protein (KSP) inhibitors with 2,3-fused indole scaffolds. J Med Chem. 2010 Jul 8;53(13):5054-8. DMDL8KY RU https://pubmed.ncbi.nlm.nih.gov/20521839 DM7M6T3 DI DM7M6T3 DM7M6T3 DN 2-(trifluoromethyl)-9H-carbazole DM7M6T3 MI TTBGTCW DM7M6T3 MN Kinesin spindle messenger RNA (KIF11 mRNA) DM7M6T3 MT DTT DM7M6T3 MA Inhibitor DM7M6T3 RN Kinesin spindle protein (KSP) inhibitors with 2,3-fused indole scaffolds. J Med Chem. 2010 Jul 8;53(13):5054-8. DM7M6T3 RU https://pubmed.ncbi.nlm.nih.gov/20521839 DMWAKFM DI DMWAKFM DMWAKFM DN 2-(trifluoromethyl)benzaldehyde thiosemicarbazone DMWAKFM MI TTEAID7 DMWAKFM MN Trypanosoma Cruzipain (Trypano CYSP) DMWAKFM MT DTT DMWAKFM MA Inhibitor DMWAKFM RN Synthesis and structure-activity relationship study of potent trypanocidal thio semicarbazone inhibitors of the trypanosomal cysteine protease cruz... J Med Chem. 2002 Jun 20;45(13):2695-707. DMWAKFM RU https://pubmed.ncbi.nlm.nih.gov/12061873 DMBLXOG DI DMBLXOG DMBLXOG DN 2,2,2-TRIFLUORO-1-(4-FLUOROPHENYL)-1-(1-(4-FLUOROPHENYL)-1H-INDAZOL-5-YL)ETHANOL (DIASTEREOMERIC MIX) DMBLXOG MI TTOZRK6 DMBLXOG MN Glucocorticoid receptor messenger RNA (GCR mRNA) DMBLXOG MT DTT DMBLXOG MA Inhibitor DMBLXOG RN 5-Functionalized indazoles as glucocorticoid receptor agonists. Bioorg Med Chem Lett. 2010 May 15;20(10):3017-20. DMBLXOG RU https://pubmed.ncbi.nlm.nih.gov/20427184 DMG4ITB DI DMG4ITB DMG4ITB DN 2,2,2-Trifluoro-N-(4-sulfamoyl-phenyl)-acetamide DMG4ITB MI TTHQPL7 DMG4ITB MN Carbonic anhydrase I (CA-I) DMG4ITB MT DTT DMG4ITB MA Inhibitor DMG4ITB RN Carbonic anhydrase inhibitors: inhibition of the tumor-associated isozymes IX and XII with a library of aromatic and heteroaromatic sulfonamides. Bioorg Med Chem Lett. 2005 Nov 1;15(21):4862-6. DMG4ITB RU https://pubmed.ncbi.nlm.nih.gov/16168653 DMG4ITB DI DMG4ITB DMG4ITB DN 2,2,2-Trifluoro-N-(4-sulfamoyl-phenyl)-acetamide DMG4ITB MI TTANPDJ DMG4ITB MN Carbonic anhydrase II (CA-II) DMG4ITB MT DTT DMG4ITB MA Inhibitor DMG4ITB RN Carbonic anhydrase inhibitors: inhibition of the tumor-associated isozymes IX and XII with a library of aromatic and heteroaromatic sulfonamides. Bioorg Med Chem Lett. 2005 Nov 1;15(21):4862-6. DMG4ITB RU https://pubmed.ncbi.nlm.nih.gov/16168653 DMG4ITB DI DMG4ITB DMG4ITB DN 2,2,2-Trifluoro-N-(4-sulfamoyl-phenyl)-acetamide DMG4ITB MI TT2LVK8 DMG4ITB MN Carbonic anhydrase IX (CA-IX) DMG4ITB MT DTT DMG4ITB MA Inhibitor DMG4ITB RN Carbonic anhydrase inhibitors: inhibition of the tumor-associated isozymes IX and XII with a library of aromatic and heteroaromatic sulfonamides. Bioorg Med Chem Lett. 2005 Nov 1;15(21):4862-6. DMG4ITB RU https://pubmed.ncbi.nlm.nih.gov/16168653 DMG4ITB DI DMG4ITB DMG4ITB DN 2,2,2-Trifluoro-N-(4-sulfamoyl-phenyl)-acetamide DMG4ITB MI TTSYM0R DMG4ITB MN Carbonic anhydrase XII (CA-XII) DMG4ITB MT DTT DMG4ITB MA Inhibitor DMG4ITB RN Carbonic anhydrase inhibitors: inhibition of the tumor-associated isozymes IX and XII with a library of aromatic and heteroaromatic sulfonamides. Bioorg Med Chem Lett. 2005 Nov 1;15(21):4862-6. DMG4ITB RU https://pubmed.ncbi.nlm.nih.gov/16168653 DMJXAF7 DI DMJXAF7 DMJXAF7 DN 2,2,2-tris-(3-fluorophenyl)-acetamide DMJXAF7 MI TTMNI76 DMJXAF7 MN Calcium-activated potassium channel (KCN) DMJXAF7 MT DTT DMJXAF7 MA Inhibitor DMJXAF7 RN Novel inhibitors of the Gardos channel for the treatment of sickle cell disease. J Med Chem. 2008 Feb 28;51(4):976-82. DMJXAF7 RU https://pubmed.ncbi.nlm.nih.gov/18232633 DMCZHEN DI DMCZHEN DMCZHEN DN 2,2,2-tris-(4-fluorophenyl)-acetamide DMCZHEN MI TTMNI76 DMCZHEN MN Calcium-activated potassium channel (KCN) DMCZHEN MT DTT DMCZHEN MA Inhibitor DMCZHEN RN Novel inhibitors of the Gardos channel for the treatment of sickle cell disease. J Med Chem. 2008 Feb 28;51(4):976-82. DMCZHEN RU https://pubmed.ncbi.nlm.nih.gov/18232633 DMG7EPF DI DMG7EPF DMG7EPF DN 2,2',3-Tribromo-4,4',5,5'-tetrahydroxybibenzyl DMG7EPF MI TT58ZYW DMG7EPF MN Mycobacterium Isocitrate lyase (MycB icl) DMG7EPF MT DTT DMG7EPF MA Inhibitor DMG7EPF RN Bromophenols as Candida albicans isocitrate lyase inhibitors. Bioorg Med Chem Lett. 2010 Nov 15;20(22):6644-8. DMG7EPF RU https://pubmed.ncbi.nlm.nih.gov/20888765 DMAYXUR DI DMAYXUR DMAYXUR DN 2,2',4,4',6'-pentahydroxychalcone DMAYXUR MI TTULVH8 DMAYXUR MN Tyrosinase (TYR) DMAYXUR MT DTT DMAYXUR MA Inhibitor DMAYXUR RN Synthesis and evaluation of 2',4',6'-trihydroxychalcones as a new class of tyrosinase inhibitors. Bioorg Med Chem. 2007 Mar 15;15(6):2396-402. DMAYXUR RU https://pubmed.ncbi.nlm.nih.gov/17267225 DMMJ613 DI DMMJ613 DMMJ613 DN 2,2',4,4'-tetrahydroxy-6'-methoxychalcone DMMJ613 MI TTULVH8 DMMJ613 MN Tyrosinase (TYR) DMMJ613 MT DTT DMMJ613 MA Inhibitor DMMJ613 RN Synthesis and evaluation of 2',4',6'-trihydroxychalcones as a new class of tyrosinase inhibitors. Bioorg Med Chem. 2007 Mar 15;15(6):2396-402. DMMJ613 RU https://pubmed.ncbi.nlm.nih.gov/17267225 DMM6KBD DI DMM6KBD DMM6KBD DN 2,2',4,4'-tetrahydroxychalcone DMM6KBD MI TTULVH8 DMM6KBD MN Tyrosinase (TYR) DMM6KBD MT DTT DMM6KBD MA Inhibitor DMM6KBD RN Synthesis and evaluation of 2',4',6'-trihydroxychalcones as a new class of tyrosinase inhibitors. Bioorg Med Chem. 2007 Mar 15;15(6):2396-402. DMM6KBD RU https://pubmed.ncbi.nlm.nih.gov/17267225 DMP9ECK DI DMP9ECK DMP9ECK DN 2,2,4-Trimethyl-6-phenyl-1,2-dihydro-quinoline DMP9ECK MI TTUV8G9 DMP9ECK MN Progesterone receptor (PGR) DMP9ECK MT DTT DMP9ECK MA Inhibitor DMP9ECK RN Discovery and preliminary SAR studies of a novel, nonsteroidal progesterone receptor antagonist pharmacophore. J Med Chem. 1998 Aug 27;41(18):3461-6. DMP9ECK RU https://pubmed.ncbi.nlm.nih.gov/9719599 DMPMOHQ DI DMPMOHQ DMPMOHQ DN 2,2'-bi(1,3,4-thiadiazole)-5,5'(4H,4'H)-dithione DMPMOHQ MI TTULVH8 DMPMOHQ MN Tyrosinase (TYR) DMPMOHQ MT DTT DMPMOHQ MA Inhibitor DMPMOHQ RN New potent inhibitors of tyrosinase: novel clues to binding of 1,3,4-thiadiazole-2(3H)-thiones, 1,3,4-oxadiazole-2(3H)-thiones, 4-amino-1,2,4-triaz... Bioorg Med Chem. 2010 Jun 1;18(11):4042-8. DMPMOHQ RU https://pubmed.ncbi.nlm.nih.gov/20452224 DMDIX40 DI DMDIX40 DMDIX40 DN 2,2-bis-(2-fluorophenyl)-2-phenylacetamide DMDIX40 MI TTMNI76 DMDIX40 MN Calcium-activated potassium channel (KCN) DMDIX40 MT DTT DMDIX40 MA Inhibitor DMDIX40 RN Novel inhibitors of the Gardos channel for the treatment of sickle cell disease. J Med Chem. 2008 Feb 28;51(4):976-82. DMDIX40 RU https://pubmed.ncbi.nlm.nih.gov/18232633 DM6ICRJ DI DM6ICRJ DM6ICRJ DN 2,2-bis-(3-fluorophenyl)-2-phenylacetamide DM6ICRJ MI TTMNI76 DM6ICRJ MN Calcium-activated potassium channel (KCN) DM6ICRJ MT DTT DM6ICRJ MA Inhibitor DM6ICRJ RN Novel inhibitors of the Gardos channel for the treatment of sickle cell disease. J Med Chem. 2008 Feb 28;51(4):976-82. DM6ICRJ RU https://pubmed.ncbi.nlm.nih.gov/18232633 DMTODR2 DI DMTODR2 DMTODR2 DN 2,2-bis(3-fluorophenyl)-N-hydroxyacetamide DMTODR2 MI TTBH0VX DMTODR2 MN Histone deacetylase (HDAC) DMTODR2 MT DTT DMTODR2 MA Inhibitor DMTODR2 RN Diphenylmethylene hydroxamic acids as selective class IIa histone deacetylase inhibitors. Bioorg Med Chem Lett. 2009 Oct 1;19(19):5684-8. DMTODR2 RU https://pubmed.ncbi.nlm.nih.gov/19699639 DMTODR2 DI DMTODR2 DMTODR2 DN 2,2-bis(3-fluorophenyl)-N-hydroxyacetamide DMTODR2 MI TTTQGH8 DMTODR2 MN Histone deacetylase 4 (HDAC4) DMTODR2 MT DTT DMTODR2 MA Inhibitor DMTODR2 RN Diphenylmethylene hydroxamic acids as selective class IIa histone deacetylase inhibitors. Bioorg Med Chem Lett. 2009 Oct 1;19(19):5684-8. DMTODR2 RU https://pubmed.ncbi.nlm.nih.gov/19699639 DM2RKD6 DI DM2RKD6 DM2RKD6 DN 2,2-bis(4-chlorophenyl)-N-hydroxyacetamide DM2RKD6 MI TTBH0VX DM2RKD6 MN Histone deacetylase (HDAC) DM2RKD6 MT DTT DM2RKD6 MA Inhibitor DM2RKD6 RN Diphenylmethylene hydroxamic acids as selective class IIa histone deacetylase inhibitors. Bioorg Med Chem Lett. 2009 Oct 1;19(19):5684-8. DM2RKD6 RU https://pubmed.ncbi.nlm.nih.gov/19699639 DM2RKD6 DI DM2RKD6 DM2RKD6 DN 2,2-bis(4-chlorophenyl)-N-hydroxyacetamide DM2RKD6 MI TTTQGH8 DM2RKD6 MN Histone deacetylase 4 (HDAC4) DM2RKD6 MT DTT DM2RKD6 MA Inhibitor DM2RKD6 RN Diphenylmethylene hydroxamic acids as selective class IIa histone deacetylase inhibitors. Bioorg Med Chem Lett. 2009 Oct 1;19(19):5684-8. DM2RKD6 RU https://pubmed.ncbi.nlm.nih.gov/19699639 DM5PWQM DI DM5PWQM DM5PWQM DN 2,2-bis(4-fluorophenyl)-N-hydroxyacetamide DM5PWQM MI TTBH0VX DM5PWQM MN Histone deacetylase (HDAC) DM5PWQM MT DTT DM5PWQM MA Inhibitor DM5PWQM RN Diphenylmethylene hydroxamic acids as selective class IIa histone deacetylase inhibitors. Bioorg Med Chem Lett. 2009 Oct 1;19(19):5684-8. DM5PWQM RU https://pubmed.ncbi.nlm.nih.gov/19699639 DM5PWQM DI DM5PWQM DM5PWQM DN 2,2-bis(4-fluorophenyl)-N-hydroxyacetamide DM5PWQM MI TTTQGH8 DM5PWQM MN Histone deacetylase 4 (HDAC4) DM5PWQM MT DTT DM5PWQM MA Inhibitor DM5PWQM RN Diphenylmethylene hydroxamic acids as selective class IIa histone deacetylase inhibitors. Bioorg Med Chem Lett. 2009 Oct 1;19(19):5684-8. DM5PWQM RU https://pubmed.ncbi.nlm.nih.gov/19699639 DMFPYU8 DI DMFPYU8 DMFPYU8 DN 2,2-Dibenzylcyclopentanol DMFPYU8 MI TT5ZWB6 DMFPYU8 MN Dihydrodiol dehydrogenase type I (AKR1C3) DMFPYU8 MT DTT DMFPYU8 MA Inhibitor DMFPYU8 RN New cyclopentane derivatives as inhibitors of steroid metabolizing enzymes AKR1C1 and AKR1C3. Eur J Med Chem. 2009 Jun;44(6):2563-71. DMFPYU8 RU https://pubmed.ncbi.nlm.nih.gov/19237229 DMKXFDA DI DMKXFDA DMKXFDA DN 2,2-difluoromevalonate 5-diphosphate DMKXFDA MI TTE5J6X DMKXFDA MN Diphosphomevalonate decarboxylase (MVD) DMKXFDA MT DTT DMKXFDA MA Inhibitor DMKXFDA RN Mutation and inhibition studies of mevalonate 5-diphosphate decarboxylase. Bioorg Med Chem Lett. 2007 Nov 15;17(22):6164-8. DMKXFDA RU https://pubmed.ncbi.nlm.nih.gov/17888661 DMPX642 DI DMPX642 DMPX642 DN 2,2-diMeBut-RYYRIK-NH2 DMPX642 MI TTNT7K8 DMPX642 MN Nociceptin receptor (OPRL1) DMPX642 MT DTT DMPX642 MA Inhibitor DMPX642 RN Designed modification of partial agonist of ORL1 nociceptin receptor for conversion into highly potent antagonist. Bioorg Med Chem. 2008 Mar 1;16(5):2635-44. DMPX642 RU https://pubmed.ncbi.nlm.nih.gov/18068993 DM34IX5 DI DM34IX5 DM34IX5 DN 2,2-Dimethoxy-1,2-diphenyl-ethanone DM34IX5 MI TTMF541 DM34IX5 MN Liver carboxylesterase (CES1) DM34IX5 MT DTT DM34IX5 MA Inhibitor DM34IX5 RN Identification and characterization of novel benzil (diphenylethane-1,2-dione) analogues as inhibitors of mammalian carboxylesterases. J Med Chem. 2005 Apr 21;48(8):2906-15. DM34IX5 RU https://pubmed.ncbi.nlm.nih.gov/15828829 DMQYCFI DI DMQYCFI DMQYCFI DN 2,2-dimethyl-2H-benzo[g]chromene-5,10-dione DMQYCFI MI TTZJYKH DMQYCFI MN Indoleamine 2,3-dioxygenase 1 (IDO1) DMQYCFI MT DTT DMQYCFI MA Inhibitor DMQYCFI RN Indoleamine 2,3-dioxygenase is the anticancer target for a novel series of potent naphthoquinone-based inhibitors. J Med Chem. 2008 Mar 27;51(6):1706-18. DMQYCFI RU https://pubmed.ncbi.nlm.nih.gov/18318466 DM7BL04 DI DM7BL04 DM7BL04 DN 2,2-dimethyl-3-methyleneheptadecane DM7BL04 MI TTDP1UC DM7BL04 MN Fatty acid amide hydrolase (FAAH) DM7BL04 MT DTT DM7BL04 MA Inhibitor DM7BL04 RN Influence of sulfur oxidation state and steric bulk upon trifluoromethyl ketone (TFK) binding kinetics to carboxylesterases and fatty acid amide hy... Bioorg Med Chem. 2008 Feb 15;16(4):2114-30. DM7BL04 RU https://pubmed.ncbi.nlm.nih.gov/18023188 DM7BL04 DI DM7BL04 DM7BL04 DN 2,2-dimethyl-3-methyleneheptadecane DM7BL04 MI TTMF541 DM7BL04 MN Liver carboxylesterase (CES1) DM7BL04 MT DTT DM7BL04 MA Inhibitor DM7BL04 RN Influence of sulfur oxidation state and steric bulk upon trifluoromethyl ketone (TFK) binding kinetics to carboxylesterases and fatty acid amide hy... Bioorg Med Chem. 2008 Feb 15;16(4):2114-30. DM7BL04 RU https://pubmed.ncbi.nlm.nih.gov/18023188 DMATB8H DI DMATB8H DMATB8H DN 2,2-Dimethyl-N-(4-sulfamoyl-phenyl)-propionamide DMATB8H MI TTANPDJ DMATB8H MN Carbonic anhydrase II (CA-II) DMATB8H MT DTT DMATB8H MA Inhibitor DMATB8H RN Carbonic anhydrase inhibitors: inhibition of the tumor-associated isozymes IX and XII with a library of aromatic and heteroaromatic sulfonamides. Bioorg Med Chem Lett. 2005 Nov 1;15(21):4862-6. DMATB8H RU https://pubmed.ncbi.nlm.nih.gov/16168653 DMATB8H DI DMATB8H DMATB8H DN 2,2-Dimethyl-N-(4-sulfamoyl-phenyl)-propionamide DMATB8H MI TT2LVK8 DMATB8H MN Carbonic anhydrase IX (CA-IX) DMATB8H MT DTT DMATB8H MA Inhibitor DMATB8H RN Carbonic anhydrase inhibitors: inhibition of the tumor-associated isozymes IX and XII with a library of aromatic and heteroaromatic sulfonamides. Bioorg Med Chem Lett. 2005 Nov 1;15(21):4862-6. DMATB8H RU https://pubmed.ncbi.nlm.nih.gov/16168653 DMATB8H DI DMATB8H DMATB8H DN 2,2-Dimethyl-N-(4-sulfamoyl-phenyl)-propionamide DMATB8H MI TTSYM0R DMATB8H MN Carbonic anhydrase XII (CA-XII) DMATB8H MT DTT DMATB8H MA Inhibitor DMATB8H RN Carbonic anhydrase inhibitors: inhibition of the tumor-associated isozymes IX and XII with a library of aromatic and heteroaromatic sulfonamides. Bioorg Med Chem Lett. 2005 Nov 1;15(21):4862-6. DMATB8H RU https://pubmed.ncbi.nlm.nih.gov/16168653 DMTBAUG DI DMTBAUG DMTBAUG DN 2,2-Diphenyl-ethylamine DMTBAUG MI TTJQOD7 DMTBAUG MN 5-HT 2A receptor (HTR2A) DMTBAUG MT DTT DMTBAUG MA Inhibitor DMTBAUG RN Exploring the relationship between binding modes of 9-(aminomethyl)-9,10-dihydroanthracene and cyproheptadine analogues at the 5-HT2A serotonin rec... Bioorg Med Chem Lett. 2001 Feb 26;11(4):563-6. DMTBAUG RU https://pubmed.ncbi.nlm.nih.gov/11229772 DMOQDBA DI DMOQDBA DMOQDBA DN 2,2'-pyridylisatogen tosylate DMOQDBA MI TTA93TL DMOQDBA MN P2Y purinoceptor 1 (P2RY1) DMOQDBA MT DTT DMOQDBA MA Modulator (allosteric modulator) DMOQDBA RN 2,2'-Pyridylisatogen tosylate antagonizes P2Y1 receptor signaling without affecting nucleotide binding. Biochem Pharmacol. 2004 Jul 15;68(2):231-7. DMOQDBA RU https://pubmed.ncbi.nlm.nih.gov/15193995 DM7H34U DI DM7H34U DM7H34U DN 2,3,3-Triphenyl-acrylonitrile DM7H34U MI TTFJ8Q1 DM7H34U MN Protein kinase C alpha (PRKCA) DM7H34U MT DTT DM7H34U MA Inhibitor DM7H34U RN Multivariate analysis by the minimum spanning tree method of the structural determinants of diphenylethylenes and triphenylacrylonitriles implicate... J Med Chem. 1992 Feb 7;35(3):573-83. DM7H34U RU https://pubmed.ncbi.nlm.nih.gov/1738150 DM7H34U DI DM7H34U DM7H34U DN 2,3,3-Triphenyl-acrylonitrile DM7H34U MI TTYPXQF DM7H34U MN Protein kinase C beta (PRKCB) DM7H34U MT DTT DM7H34U MA Inhibitor DM7H34U RN Multivariate analysis by the minimum spanning tree method of the structural determinants of diphenylethylenes and triphenylacrylonitriles implicate... J Med Chem. 1992 Feb 7;35(3):573-83. DM7H34U RU https://pubmed.ncbi.nlm.nih.gov/1738150 DM7H34U DI DM7H34U DM7H34U DN 2,3,3-Triphenyl-acrylonitrile DM7H34U MI TT9WJ8U DM7H34U MN Protein kinase C delta (PRKCD) DM7H34U MT DTT DM7H34U MA Inhibitor DM7H34U RN Multivariate analysis by the minimum spanning tree method of the structural determinants of diphenylethylenes and triphenylacrylonitriles implicate... J Med Chem. 1992 Feb 7;35(3):573-83. DM7H34U RU https://pubmed.ncbi.nlm.nih.gov/1738150 DM7H34U DI DM7H34U DM7H34U DN 2,3,3-Triphenyl-acrylonitrile DM7H34U MI TTBZ7OD DM7H34U MN Protein kinase C epsilon (PRKCE) DM7H34U MT DTT DM7H34U MA Inhibitor DM7H34U RN Multivariate analysis by the minimum spanning tree method of the structural determinants of diphenylethylenes and triphenylacrylonitriles implicate... J Med Chem. 1992 Feb 7;35(3):573-83. DM7H34U RU https://pubmed.ncbi.nlm.nih.gov/1738150 DM7H34U DI DM7H34U DM7H34U DN 2,3,3-Triphenyl-acrylonitrile DM7H34U MI TTRFOXJ DM7H34U MN Protein kinase C gamma (PRKCG) DM7H34U MT DTT DM7H34U MA Inhibitor DM7H34U RN Multivariate analysis by the minimum spanning tree method of the structural determinants of diphenylethylenes and triphenylacrylonitriles implicate... J Med Chem. 1992 Feb 7;35(3):573-83. DM7H34U RU https://pubmed.ncbi.nlm.nih.gov/1738150 DM7H34U DI DM7H34U DM7H34U DN 2,3,3-Triphenyl-acrylonitrile DM7H34U MI TT8QL1J DM7H34U MN Protein kinase C theta (PRKCQ) DM7H34U MT DTT DM7H34U MA Inhibitor DM7H34U RN Multivariate analysis by the minimum spanning tree method of the structural determinants of diphenylethylenes and triphenylacrylonitriles implicate... J Med Chem. 1992 Feb 7;35(3):573-83. DM7H34U RU https://pubmed.ncbi.nlm.nih.gov/1738150 DM7H34U DI DM7H34U DM7H34U DN 2,3,3-Triphenyl-acrylonitrile DM7H34U MI TTUWGRA DM7H34U MN Protein kinase C zeta (PRKCZ) DM7H34U MT DTT DM7H34U MA Inhibitor DM7H34U RN Multivariate analysis by the minimum spanning tree method of the structural determinants of diphenylethylenes and triphenylacrylonitriles implicate... J Med Chem. 1992 Feb 7;35(3):573-83. DM7H34U RU https://pubmed.ncbi.nlm.nih.gov/1738150 DMV1CX0 DI DMV1CX0 DMV1CX0 DN 2,3,4,11-tetrahydro-1H-benzo[a]carbazole DMV1CX0 MI TTBGTCW DMV1CX0 MN Kinesin spindle messenger RNA (KIF11 mRNA) DMV1CX0 MT DTT DMV1CX0 MA Inhibitor DMV1CX0 RN Kinesin spindle protein (KSP) inhibitors with 2,3-fused indole scaffolds. J Med Chem. 2010 Jul 8;53(13):5054-8. DMV1CX0 RU https://pubmed.ncbi.nlm.nih.gov/20521839 DMK4LTB DI DMK4LTB DMK4LTB DN 2,3,4,5-Tetrabromo-6-(2,4-dibromo-phenoxy)-phenol DMK4LTB MI TT12ABZ DMK4LTB MN Arachidonate 12-lipoxygenase (12-LOX) DMK4LTB MT DTT DMK4LTB MA Inhibitor DMK4LTB RN Probing the activity differences of simple and complex brominated aryl compounds against 15-soybean, 15-human, and 12-human lipoxygenase. J Med Chem. 2004 Jul 29;47(16):4060-5. DMK4LTB RU https://pubmed.ncbi.nlm.nih.gov/15267244 DMK4LTB DI DMK4LTB DMK4LTB DN 2,3,4,5-Tetrabromo-6-(2,4-dibromo-phenoxy)-phenol DMK4LTB MI TTN9T81 DMK4LTB MN Arachidonate 15-lipoxygenase (15-LOX) DMK4LTB MT DTT DMK4LTB MA Inhibitor DMK4LTB RN Probing the activity differences of simple and complex brominated aryl compounds against 15-soybean, 15-human, and 12-human lipoxygenase. J Med Chem. 2004 Jul 29;47(16):4060-5. DMK4LTB RU https://pubmed.ncbi.nlm.nih.gov/15267244 DMGQE4B DI DMGQE4B DMGQE4B DN 2,3,4,5-Tetrafluoro-6-pentafluorophenylazo-phenol DMGQE4B MI TTRA5BZ DMGQE4B MN Steroid 17-alpha-monooxygenase (S17AH) DMGQE4B MT DTT DMGQE4B MA Inhibitor DMGQE4B RN Hydroxyperfluoroazobenzenes: novel inhibitors of enzymes of androgen biosynthesis. J Med Chem. 1990 Sep;33(9):2452-5. DMGQE4B RU https://pubmed.ncbi.nlm.nih.gov/2391687 DM1RE9Q DI DM1RE9Q DM1RE9Q DN 2,3,4,5-Tetrahydro-1H-benzo[c]azepine DM1RE9Q MI TTWG9A4 DM1RE9Q MN Adrenergic receptor alpha-2A (ADRA2A) DM1RE9Q MT DTT DM1RE9Q MA Inhibitor DM1RE9Q RN Effect of ring size or an additional heteroatom on the potency and selectivity of bicyclic benzylamine-type inhibitors of phenylethanolamine N-meth... J Med Chem. 1996 Aug 30;39(18):3539-46. DM1RE9Q RU https://pubmed.ncbi.nlm.nih.gov/8784452 DM1RE9Q DI DM1RE9Q DM1RE9Q DN 2,3,4,5-Tetrahydro-1H-benzo[c]azepine DM1RE9Q MI TTWM4TY DM1RE9Q MN Adrenergic receptor alpha-2B (ADRA2B) DM1RE9Q MT DTT DM1RE9Q MA Inhibitor DM1RE9Q RN Effect of ring size or an additional heteroatom on the potency and selectivity of bicyclic benzylamine-type inhibitors of phenylethanolamine N-meth... J Med Chem. 1996 Aug 30;39(18):3539-46. DM1RE9Q RU https://pubmed.ncbi.nlm.nih.gov/8784452 DM1RE9Q DI DM1RE9Q DM1RE9Q DN 2,3,4,5-Tetrahydro-1H-benzo[c]azepine DM1RE9Q MI TT2NUT5 DM1RE9Q MN Adrenergic receptor alpha-2C (ADRA2C) DM1RE9Q MT DTT DM1RE9Q MA Inhibitor DM1RE9Q RN Effect of ring size or an additional heteroatom on the potency and selectivity of bicyclic benzylamine-type inhibitors of phenylethanolamine N-meth... J Med Chem. 1996 Aug 30;39(18):3539-46. DM1RE9Q RU https://pubmed.ncbi.nlm.nih.gov/8784452 DM4EZOB DI DM4EZOB DM4EZOB DN 2,3,4,5-Tetrahydro-1H-benzo[e][1,4]diazepine DM4EZOB MI TTWG9A4 DM4EZOB MN Adrenergic receptor alpha-2A (ADRA2A) DM4EZOB MT DTT DM4EZOB MA Inhibitor DM4EZOB RN Effect of ring size or an additional heteroatom on the potency and selectivity of bicyclic benzylamine-type inhibitors of phenylethanolamine N-meth... J Med Chem. 1996 Aug 30;39(18):3539-46. DM4EZOB RU https://pubmed.ncbi.nlm.nih.gov/8784452 DM4EZOB DI DM4EZOB DM4EZOB DN 2,3,4,5-Tetrahydro-1H-benzo[e][1,4]diazepine DM4EZOB MI TTWM4TY DM4EZOB MN Adrenergic receptor alpha-2B (ADRA2B) DM4EZOB MT DTT DM4EZOB MA Inhibitor DM4EZOB RN Effect of ring size or an additional heteroatom on the potency and selectivity of bicyclic benzylamine-type inhibitors of phenylethanolamine N-meth... J Med Chem. 1996 Aug 30;39(18):3539-46. DM4EZOB RU https://pubmed.ncbi.nlm.nih.gov/8784452 DM4EZOB DI DM4EZOB DM4EZOB DN 2,3,4,5-Tetrahydro-1H-benzo[e][1,4]diazepine DM4EZOB MI TT2NUT5 DM4EZOB MN Adrenergic receptor alpha-2C (ADRA2C) DM4EZOB MT DTT DM4EZOB MA Inhibitor DM4EZOB RN Effect of ring size or an additional heteroatom on the potency and selectivity of bicyclic benzylamine-type inhibitors of phenylethanolamine N-meth... J Med Chem. 1996 Aug 30;39(18):3539-46. DM4EZOB RU https://pubmed.ncbi.nlm.nih.gov/8784452 DMX8NYD DI DMX8NYD DMX8NYD DN 2,3,4,5-Tetrahydro-1H-pyrido[4,3-b]indole DMX8NYD MI TT3WG5C DMX8NYD MN Monoamine oxidase type A (MAO-A) DMX8NYD MT DTT DMX8NYD MA Inhibitor DMX8NYD RN Binding of beta-carbolines at imidazoline I2 receptors: a structure-affinity investigation. Bioorg Med Chem Lett. 2004 Feb 23;14(4):999-1002. DMX8NYD RU https://pubmed.ncbi.nlm.nih.gov/15013009 DMX8NYD DI DMX8NYD DMX8NYD DN 2,3,4,5-Tetrahydro-1H-pyrido[4,3-b]indole DMX8NYD MI TTGP7BY DMX8NYD MN Monoamine oxidase type B (MAO-B) DMX8NYD MT DTT DMX8NYD MA Inhibitor DMX8NYD RN Binding of beta-carbolines at imidazoline I2 receptors: a structure-affinity investigation. Bioorg Med Chem Lett. 2004 Feb 23;14(4):999-1002. DMX8NYD RU https://pubmed.ncbi.nlm.nih.gov/15013009 DMOFG4M DI DMOFG4M DMOFG4M DN 2,3,4,5-Tetrahydro-benzo[f][1,4]oxazepine DMOFG4M MI TTWG9A4 DMOFG4M MN Adrenergic receptor alpha-2A (ADRA2A) DMOFG4M MT DTT DMOFG4M MA Inhibitor DMOFG4M RN Effect of ring size or an additional heteroatom on the potency and selectivity of bicyclic benzylamine-type inhibitors of phenylethanolamine N-meth... J Med Chem. 1996 Aug 30;39(18):3539-46. DMOFG4M RU https://pubmed.ncbi.nlm.nih.gov/8784452 DMOFG4M DI DMOFG4M DMOFG4M DN 2,3,4,5-Tetrahydro-benzo[f][1,4]oxazepine DMOFG4M MI TTWM4TY DMOFG4M MN Adrenergic receptor alpha-2B (ADRA2B) DMOFG4M MT DTT DMOFG4M MA Inhibitor DMOFG4M RN Effect of ring size or an additional heteroatom on the potency and selectivity of bicyclic benzylamine-type inhibitors of phenylethanolamine N-meth... J Med Chem. 1996 Aug 30;39(18):3539-46. DMOFG4M RU https://pubmed.ncbi.nlm.nih.gov/8784452 DMOFG4M DI DMOFG4M DMOFG4M DN 2,3,4,5-Tetrahydro-benzo[f][1,4]oxazepine DMOFG4M MI TT2NUT5 DMOFG4M MN Adrenergic receptor alpha-2C (ADRA2C) DMOFG4M MT DTT DMOFG4M MA Inhibitor DMOFG4M RN Effect of ring size or an additional heteroatom on the potency and selectivity of bicyclic benzylamine-type inhibitors of phenylethanolamine N-meth... J Med Chem. 1996 Aug 30;39(18):3539-46. DMOFG4M RU https://pubmed.ncbi.nlm.nih.gov/8784452 DMXAS25 DI DMXAS25 DMXAS25 DN 2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide DMXAS25 MI TTUF2HO DMXAS25 MN NAD-dependent deacetylase sirtuin-1 (SIRT1) DMXAS25 MT DTT DMXAS25 MA Inhibitor DMXAS25 RN Discovery of indoles as potent and selective inhibitors of the deacetylase SIRT1. J Med Chem. 2005 Dec 15;48(25):8045-54. DMXAS25 RU https://pubmed.ncbi.nlm.nih.gov/16335928 DMQYEZP DI DMQYEZP DMQYEZP DN 2,3,4-tribromo-6-(2,4-dibromophenoxy)phenol DMQYEZP MI TTCFP0V DMQYEZP MN Glutamine amidotransferase (GMPS) DMQYEZP MT DTT DMQYEZP MA Inhibitor DMQYEZP RN Enzyme inhibitors: new and known polybrominated phenols and diphenyl ethers from four Indo-Pacific Dysidea sponges. J Nat Prod. 1995 Sep;58(9):1384-91. DMQYEZP RU https://pubmed.ncbi.nlm.nih.gov/7494145 DMCAZ32 DI DMCAZ32 DMCAZ32 DN 2,3,4-trihydroxy-5-isopropyl-N-phenyl-benzamide DMCAZ32 MI TTJGNVC DMCAZ32 MN Apoptosis regulator Bcl-2 (BCL-2) DMCAZ32 MT DTT DMCAZ32 MA Inhibitor DMCAZ32 RN Structure-based design of potent small-molecule inhibitors of anti-apoptotic Bcl-2 proteins. J Med Chem. 2006 Oct 19;49(21):6139-42. DMCAZ32 RU https://pubmed.ncbi.nlm.nih.gov/17034116 DMWHK35 DI DMWHK35 DMWHK35 DN 2,3,4-trihydroxybenzoic acid DMWHK35 MI TT2IYXF DMWHK35 MN L-selectin (SELL) DMWHK35 MT DTT DMWHK35 MA Inhibitor DMWHK35 RN Rational design of novel, potent small molecule pan-selectin antagonists. J Med Chem. 2007 Mar 22;50(6):1101-15. DMWHK35 RU https://pubmed.ncbi.nlm.nih.gov/17302397 DMWHK35 DI DMWHK35 DMWHK35 DN 2,3,4-trihydroxybenzoic acid DMWHK35 MI TTE5VG0 DMWHK35 MN P-selectin (SELP) DMWHK35 MT DTT DMWHK35 MA Inhibitor DMWHK35 RN Rational design of novel, potent small molecule pan-selectin antagonists. J Med Chem. 2007 Mar 22;50(6):1101-15. DMWHK35 RU https://pubmed.ncbi.nlm.nih.gov/17302397 DMPRF1X DI DMPRF1X DMPRF1X DN 2,3,4-Trimethoxy-4'-amino-trans-stilbene DMPRF1X MI TTSZLWK DMPRF1X MN Aromatase (CYP19A1) DMPRF1X MT DTT DMPRF1X MA Inhibitor DMPRF1X RN Design, synthesis, and biological evaluation of resveratrol analogues as aromatase and quinone reductase 2 inhibitors for chemoprevention of cancer. Bioorg Med Chem. 2010 Jul 15;18(14):5352-66. DMPRF1X RU https://pubmed.ncbi.nlm.nih.gov/20558073 DM592YS DI DM592YS DM592YS DN 2,3,5,6-Tetrafluoro-4-Methoxy-Benzamide DM592YS MI TTFPQV7 DM592YS MN Galectin-3 (LGALS3) DM592YS MT DTT DM592YS MA Inhibitor DM592YS RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DM592YS RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMRVYKQ DI DMRVYKQ DMRVYKQ DN 2,3,5,6-Tetrafluoro-4-pentafluorophenylazo-phenol DMRVYKQ MI TTRA5BZ DMRVYKQ MN Steroid 17-alpha-monooxygenase (S17AH) DMRVYKQ MT DTT DMRVYKQ MA Inhibitor DMRVYKQ RN Hydroxyperfluoroazobenzenes: novel inhibitors of enzymes of androgen biosynthesis. J Med Chem. 1990 Sep;33(9):2452-5. DMRVYKQ RU https://pubmed.ncbi.nlm.nih.gov/2391687 DMRVYKQ DI DMRVYKQ DMRVYKQ DN 2,3,5,6-Tetrafluoro-4-pentafluorophenylazo-phenol DMRVYKQ MI TTTU72V DMRVYKQ MN Steroid 5-alpha-reductase 1 (SRD5A1) DMRVYKQ MT DTT DMRVYKQ MA Inhibitor DMRVYKQ RN Hydroxyperfluoroazobenzenes: novel inhibitors of enzymes of androgen biosynthesis. J Med Chem. 1990 Sep;33(9):2452-5. DMRVYKQ RU https://pubmed.ncbi.nlm.nih.gov/2391687 DMRVYKQ DI DMRVYKQ DMRVYKQ DN 2,3,5,6-Tetrafluoro-4-pentafluorophenylazo-phenol DMRVYKQ MI TTT02K8 DMRVYKQ MN Steroid 5-alpha-reductase 2 (SRD5A2) DMRVYKQ MT DTT DMRVYKQ MA Inhibitor DMRVYKQ RN Hydroxyperfluoroazobenzenes: novel inhibitors of enzymes of androgen biosynthesis. J Med Chem. 1990 Sep;33(9):2452-5. DMRVYKQ RU https://pubmed.ncbi.nlm.nih.gov/2391687 DMLI5UT DI DMLI5UT DMLI5UT DN 2,3,5-Trimethoxy-4'-amino-trans-stilbene DMLI5UT MI TTSZLWK DMLI5UT MN Aromatase (CYP19A1) DMLI5UT MT DTT DMLI5UT MA Inhibitor DMLI5UT RN Design, synthesis, and biological evaluation of resveratrol analogues as aromatase and quinone reductase 2 inhibitors for chemoprevention of cancer. Bioorg Med Chem. 2010 Jul 15;18(14):5352-66. DMLI5UT RU https://pubmed.ncbi.nlm.nih.gov/20558073 DMCKO6T DI DMCKO6T DMCKO6T DN 2,3,7-trichloro-5-nitroquinoxaline (TNQX) DMCKO6T MI TTUJFD0 DMCKO6T MN Telomerase reverse transcriptase (TERT) DMCKO6T MT DTT DMCKO6T MA Inhibitor DMCKO6T RN Identification of a quinoxaline derivative that is a potent telomerase inhibitor leading to cellular senescence of human cancer cells. Biochem J. 2003 Jul 15;373(Pt 2):523-9. DMCKO6T RU https://pubmed.ncbi.nlm.nih.gov/12689331 DMOB7P6 DI DMOB7P6 DMOB7P6 DN 2',3'-ddATP DMOB7P6 MI TT84ETX DMOB7P6 MN Human immunodeficiency virus Reverse transcriptase (HIV RT) DMOB7P6 MT DTT DMOB7P6 MA Inhibitor DMOB7P6 RN Synthesis of 2',3'-dideoxynucleoside 5'-alpha-P-borano-beta,gamma-(difluoromethylene)triphosphates and their inhibition of HIV-1 reverse transcript... J Med Chem. 2005 Apr 7;48(7):2695-700. DMOB7P6 RU https://pubmed.ncbi.nlm.nih.gov/15801860 DMOB7P6 DI DMOB7P6 DMOB7P6 DN 2',3'-ddATP DMOB7P6 MI TTA93TL DMOB7P6 MN P2Y purinoceptor 1 (P2RY1) DMOB7P6 MT DTT DMOB7P6 MA Agonist DMOB7P6 RN An examination of deoxyadenosine 5'(alpha-thio)triphosphate as a ligand to define P2Y receptors and its selectivity as a low potency partial agonist of the P2Y1 receptor. Br J Pharmacol. 1997 May;121(2):338-44. DMOB7P6 RU https://pubmed.ncbi.nlm.nih.gov/9154346 DM2UWDR DI DM2UWDR DM2UWDR DN 2,3'-diamino-3,4,4',5-tetramethoxy-(Z)-stillbene DM2UWDR MI TTYFKSZ DM2UWDR MN Tubulin beta (TUBB) DM2UWDR MT DTT DM2UWDR MA Inhibitor DM2UWDR RN 2-amino and 2'-aminocombretastatin derivatives as potent antimitotic agents. J Med Chem. 2006 Oct 19;49(21):6412-5. DM2UWDR RU https://pubmed.ncbi.nlm.nih.gov/17034147 DM2UWDR DI DM2UWDR DM2UWDR DN 2,3'-diamino-3,4,4',5-tetramethoxy-(Z)-stillbene DM2UWDR MI TTJ2PTI DM2UWDR MN Tubulin beta-2 chain (TUBB2) DM2UWDR MT DTT DM2UWDR MA Inhibitor DM2UWDR RN 2-amino and 2'-aminocombretastatin derivatives as potent antimitotic agents. J Med Chem. 2006 Oct 19;49(21):6412-5. DM2UWDR RU https://pubmed.ncbi.nlm.nih.gov/17034147 DMPCGSD DI DMPCGSD DMPCGSD DN 2,3-dichloro-1,4-naphthoquinone DMPCGSD MI TTZJYKH DMPCGSD MN Indoleamine 2,3-dioxygenase 1 (IDO1) DMPCGSD MT DTT DMPCGSD MA Inhibitor DMPCGSD RN Indoleamine 2,3-dioxygenase is the anticancer target for a novel series of potent naphthoquinone-based inhibitors. J Med Chem. 2008 Mar 27;51(6):1706-18. DMPCGSD RU https://pubmed.ncbi.nlm.nih.gov/18318466 DM6SBPI DI DM6SBPI DM6SBPI DN 2,3-Didehydroalanine DM6SBPI MI TT3DQUT DM6SBPI MN Bacterial Lantibiotic mersacidin (Bact glmM) DM6SBPI MT DTT DM6SBPI MA Inhibitor DM6SBPI RN DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Nucleic Acids Res. 2011 Jan;39(Database issue):D1035-41. DM6SBPI RU https://pubmed.ncbi.nlm.nih.gov/21059682 DMCXR4M DI DMCXR4M DMCXR4M DN 2',3'-Dideoxycytidine-5'-Monophosphate DMCXR4M MI TTMFYEC DMCXR4M MN Streptococcus Cytidylate kinase (Stre-coc cmk) DMCXR4M MT DTT DMCXR4M MA Inhibitor DMCXR4M RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMCXR4M RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMEQXUD DI DMEQXUD DMEQXUD DN 2',3'-Dideoxythymidine-5'-Monophosphate DMEQXUD MI TT5B8AX DMEQXUD MN Mycobacterium Thymidine monophosphate kinase (MycB tmk) DMEQXUD MT DTT DMEQXUD MA Inhibitor DMEQXUD RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMEQXUD RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMJB7W1 DI DMJB7W1 DMJB7W1 DN 2,3-dihydro-1,4-dithiin-1,1,4,4-tetroxide DMJB7W1 MI TTOPAY7 DMJB7W1 MN Galanin receptor (GAL-R) DMJB7W1 MT DTT DMJB7W1 MA Antagonist DMJB7W1 RN 2,3-Dihydro-dithiin and -dithiepine-1,1,4,4-tetroxides: small molecule non-peptide antagonists of the human galanin hGAL-1 receptor. Bioorg Med Chem. 2000 Jun;8(6):1383-91. DMJB7W1 RU https://pubmed.ncbi.nlm.nih.gov/10896115 DMB3WI8 DI DMB3WI8 DMB3WI8 DN 2,3-dihydro-1H-benzo[de]isoquinolin-1-one DMB3WI8 MI TTVDSZ0 DMB3WI8 MN Poly [ADP-ribose] polymerase 1 (PARP1) DMB3WI8 MT DTT DMB3WI8 MA Inhibitor DMB3WI8 RN Discovery and SAR of novel, potent and selective hexahydrobenzonaphthyridinone inhibitors of poly(ADP-ribose)polymerase-1 (PARP-1). Bioorg Med Chem Lett. 2010 Jan 15;20(2):448-52. DMB3WI8 RU https://pubmed.ncbi.nlm.nih.gov/20015648 DM46MKY DI DM46MKY DM46MKY DN 2,3-dihydro-1H-indene-5-sulfonamide DM46MKY MI TTUNARX DM46MKY MN Carbonic anhydrase (CA) DM46MKY MT DTT DM46MKY MA Inhibitor DM46MKY RN Indanesulfonamides as carbonic anhydrase inhibitors and anticonvulsant agents: structure-activity relationship and pharmacological evaluation. Eur J Med Chem. 2008 Dec;43(12):2853-60. DM46MKY RU https://pubmed.ncbi.nlm.nih.gov/18406497 DM46MKY DI DM46MKY DM46MKY DN 2,3-dihydro-1H-indene-5-sulfonamide DM46MKY MI TTHQPL7 DM46MKY MN Carbonic anhydrase I (CA-I) DM46MKY MT DTT DM46MKY MA Inhibitor DM46MKY RN Carbonic anhydrase inhibitors. Design of anticonvulsant sulfonamides incorporating indane moieties. Bioorg Med Chem Lett. 2004 Dec 6;14(23):5781-6. DM46MKY RU https://pubmed.ncbi.nlm.nih.gov/15501040 DM46MKY DI DM46MKY DM46MKY DN 2,3-dihydro-1H-indene-5-sulfonamide DM46MKY MI TTANPDJ DM46MKY MN Carbonic anhydrase II (CA-II) DM46MKY MT DTT DM46MKY MA Inhibitor DM46MKY RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DM46MKY RU https://pubmed.ncbi.nlm.nih.gov/10592235 DM46MKY DI DM46MKY DM46MKY DN 2,3-dihydro-1H-indene-5-sulfonamide DM46MKY MI TTSYM0R DM46MKY MN Carbonic anhydrase XII (CA-XII) DM46MKY MT DTT DM46MKY MA Inhibitor DM46MKY RN Indanesulfonamides as carbonic anhydrase inhibitors and anticonvulsant agents: structure-activity relationship and pharmacological evaluation. Eur J Med Chem. 2008 Dec;43(12):2853-60. DM46MKY RU https://pubmed.ncbi.nlm.nih.gov/18406497 DM46MKY DI DM46MKY DM46MKY DN 2,3-dihydro-1H-indene-5-sulfonamide DM46MKY MI TTEYTKG DM46MKY MN Carbonic anhydrase XIV (CA-XIV) DM46MKY MT DTT DM46MKY MA Inhibitor DM46MKY RN Indanesulfonamides as carbonic anhydrase inhibitors and anticonvulsant agents: structure-activity relationship and pharmacological evaluation. Eur J Med Chem. 2008 Dec;43(12):2853-60. DM46MKY RU https://pubmed.ncbi.nlm.nih.gov/18406497 DM3URJG DI DM3URJG DM3URJG DN 2,3-Dihydro-1H-indol-5-ol DM3URJG MI TTEX248 DM3URJG MN Dopamine D2 receptor (D2R) DM3URJG MT DTT DM3URJG MA Inhibitor DM3URJG RN D4 dopamine receptor-selective compounds from the Chinese plant Phoebe chekiangensis, Bioorg. Med. Chem. Lett. 7(9):1207-1212 (1997). DM3URJG RU http://www.sciencedirect.com/science/article/pii/S0960894X97001947 DMWI9XS DI DMWI9XS DMWI9XS DN 2,3-Dihydro-1H-isoindole DMWI9XS MI TTWG9A4 DMWI9XS MN Adrenergic receptor alpha-2A (ADRA2A) DMWI9XS MT DTT DMWI9XS MA Inhibitor DMWI9XS RN Effect of ring size or an additional heteroatom on the potency and selectivity of bicyclic benzylamine-type inhibitors of phenylethanolamine N-meth... J Med Chem. 1996 Aug 30;39(18):3539-46. DMWI9XS RU https://pubmed.ncbi.nlm.nih.gov/8784452 DMWI9XS DI DMWI9XS DMWI9XS DN 2,3-Dihydro-1H-isoindole DMWI9XS MI TTWM4TY DMWI9XS MN Adrenergic receptor alpha-2B (ADRA2B) DMWI9XS MT DTT DMWI9XS MA Inhibitor DMWI9XS RN Effect of ring size or an additional heteroatom on the potency and selectivity of bicyclic benzylamine-type inhibitors of phenylethanolamine N-meth... J Med Chem. 1996 Aug 30;39(18):3539-46. DMWI9XS RU https://pubmed.ncbi.nlm.nih.gov/8784452 DMWI9XS DI DMWI9XS DMWI9XS DN 2,3-Dihydro-1H-isoindole DMWI9XS MI TT2NUT5 DMWI9XS MN Adrenergic receptor alpha-2C (ADRA2C) DMWI9XS MT DTT DMWI9XS MA Inhibitor DMWI9XS RN Effect of ring size or an additional heteroatom on the potency and selectivity of bicyclic benzylamine-type inhibitors of phenylethanolamine N-meth... J Med Chem. 1996 Aug 30;39(18):3539-46. DMWI9XS RU https://pubmed.ncbi.nlm.nih.gov/8784452 DMUW94S DI DMUW94S DMUW94S DN 2,3-dihydrobenzo[d]thiazole-2-thiol DMUW94S MI TTZJYKH DMUW94S MN Indoleamine 2,3-dioxygenase 1 (IDO1) DMUW94S MT DTT DMUW94S MA Inhibitor DMUW94S RN Rational design of indoleamine 2,3-dioxygenase inhibitors. J Med Chem. 2010 Feb 11;53(3):1172-89. DMUW94S RU https://pubmed.ncbi.nlm.nih.gov/20055453 DMYHFUO DI DMYHFUO DMYHFUO DN 2,3-dihydropyrrolo[2,1-b]quinazolin-9(1H)-imine DMYHFUO MI TT1RS9F DMYHFUO MN Acetylcholinesterase (AChE) DMYHFUO MT DTT DMYHFUO MA Inhibitor DMYHFUO RN Homobivalent quinazolinimines as novel nanomolar inhibitors of cholinesterases with dirigible selectivity toward butyrylcholinesterase. J Med Chem. 2006 Sep 7;49(18):5411-3. DMYHFUO RU https://pubmed.ncbi.nlm.nih.gov/16942014 DMYHFUO DI DMYHFUO DMYHFUO DN 2,3-dihydropyrrolo[2,1-b]quinazolin-9(1H)-imine DMYHFUO MI TTEB0GD DMYHFUO MN Cholinesterase (BCHE) DMYHFUO MT DTT DMYHFUO MA Inhibitor DMYHFUO RN Homobivalent quinazolinimines as novel nanomolar inhibitors of cholinesterases with dirigible selectivity toward butyrylcholinesterase. J Med Chem. 2006 Sep 7;49(18):5411-3. DMYHFUO RU https://pubmed.ncbi.nlm.nih.gov/16942014 DMOWNB4 DI DMOWNB4 DMOWNB4 DN 2,3-dihydroxypropanal DMOWNB4 MI DED2FW3 DMOWNB4 MN Aldo-keto reductase 1A1 (AKR1A1) DMOWNB4 MT DME DMOWNB4 MA Metabolism DMOWNB4 RN The C-terminal loop of aldehyde reductase determines the substrate and inhibitor specificity. Biochemistry. 1996 Nov 12;35(45):14276-80. DMOWNB4 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=8916913 DMOWNB4 DI DMOWNB4 DMOWNB4 DN 2,3-dihydroxypropanal DMOWNB4 MI TTFBNVI DMOWNB4 MN Aldose reductase (AKR1B1) DMOWNB4 MT DTT DMOWNB4 MA Inhibitor DMOWNB4 RN Structural basis for the high all-trans-retinaldehyde reductase activity of the tumor marker AKR1B10. Proc Natl Acad Sci U S A. 2007 Dec 26;104(52):20764-9. DMOWNB4 RU https://pubmed.ncbi.nlm.nih.gov/18087047 DML92OK DI DML92OK DML92OK DN 2,3-dimethoxy-2'-hydroxychalcone DML92OK MI TTVKILB DML92OK MN Prostaglandin G/H synthase 2 (COX-2) DML92OK MT DTT DML92OK MA Inhibitor DML92OK RN Inhibitory activity of prostaglandin E2 production by the synthetic 2'-hydroxychalcone analogues: Synthesis and SAR study. Bioorg Med Chem Lett. 2009 Mar 15;19(6):1650-3. DML92OK RU https://pubmed.ncbi.nlm.nih.gov/19233646 DM9C0YZ DI DM9C0YZ DM9C0YZ DN 2,3-Dimethoxy-4'-amino-trans-stilbene DM9C0YZ MI TTSZLWK DM9C0YZ MN Aromatase (CYP19A1) DM9C0YZ MT DTT DM9C0YZ MA Inhibitor DM9C0YZ RN Design, synthesis, and biological evaluation of resveratrol analogues as aromatase and quinone reductase 2 inhibitors for chemoprevention of cancer. Bioorg Med Chem. 2010 Jul 15;18(14):5352-66. DM9C0YZ RU https://pubmed.ncbi.nlm.nih.gov/20558073 DMEB47J DI DMEB47J DMEB47J DN 2,3-Dimethoxybenzo[i]phenanthridines DMEB47J MI TTGTQHC DMEB47J MN DNA topoisomerase I (TOP1) DMEB47J MT DTT DMEB47J MA Activator DMEB47J RN 2,3-Dimethoxybenzo[i]phenanthridines: topoisomerase I-targeting anticancer agents. Bioorg Med Chem. 2003 Feb 20;11(4):521-8. DMEB47J RU https://pubmed.ncbi.nlm.nih.gov/12538017 DMGXVBA DI DMGXVBA DMGXVBA DN 2,3-DIMETHYL-1,4-NAPHTHOQUINONE DMGXVBA MI TTHDSE2 DMGXVBA MN Bacterial Fumarate reductase flavoprotein (Bact frdA) DMGXVBA MT DTT DMGXVBA MA Inhibitor DMGXVBA RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DMGXVBA RU https://pubmed.ncbi.nlm.nih.gov/10592235 DMKV9EZ DI DMKV9EZ DMKV9EZ DN 2,3-Dimethylnaphtho[2,3-f]quinoxaline-7,12-dione DMKV9EZ MI TTQY2EJ DMKV9EZ MN TERT messenger RNA (TERT mRNA) DMKV9EZ MT DTT DMKV9EZ MA Inhibitor DMKV9EZ RN Synthesis, cytotoxicity and human telomerase inhibition activities of a series of 1,2-heteroannelated anthraquinones and anthra[1,2-d]imidazole-6,1... Bioorg Med Chem. 2009 Nov 1;17(21):7418-28. DMKV9EZ RU https://pubmed.ncbi.nlm.nih.gov/19804981 DM8C43L DI DM8C43L DM8C43L DN 2,3-dioxoindoline-7-carboxylic acid DM8C43L MI TTGX0HR DM8C43L MN Bacterial DNA ligase (Bact ligA) DM8C43L MT DTT DM8C43L MA Inhibitor DM8C43L RN Identification and validation of human DNA ligase inhibitors using computer-aided drug design. J Med Chem. 2008 Aug 14;51(15):4553-62. DM8C43L RU https://pubmed.ncbi.nlm.nih.gov/18630893 DMC3UYH DI DMC3UYH DMC3UYH DN 2,3-diphenyl-1H-indole DMC3UYH MI TTZAYWL DMC3UYH MN Estrogen receptor (ESR) DMC3UYH MT DTT DMC3UYH MA Inhibitor DMC3UYH RN Estrogen receptor beta selective ligands: discovery and SAR of novel heterocyclic ligands. Bioorg Med Chem Lett. 2005 Dec 15;15(24):5562-6. DMC3UYH RU https://pubmed.ncbi.nlm.nih.gov/16219463 DMC3UYH DI DMC3UYH DMC3UYH DN 2,3-diphenyl-1H-indole DMC3UYH MI TTOM3J0 DMC3UYH MN Estrogen receptor beta (ESR2) DMC3UYH MT DTT DMC3UYH MA Inhibitor DMC3UYH RN Estrogen receptor beta selective ligands: discovery and SAR of novel heterocyclic ligands. Bioorg Med Chem Lett. 2005 Dec 15;15(24):5562-6. DMC3UYH RU https://pubmed.ncbi.nlm.nih.gov/16219463 DMI2PY7 DI DMI2PY7 DMI2PY7 DN 2,4,3',5'-tetrahydroxybibenzyl DMI2PY7 MI TTULVH8 DMI2PY7 MN Tyrosinase (TYR) DMI2PY7 MT DTT DMI2PY7 MA Inhibitor DMI2PY7 RN Chemical transformations of oxyresveratrol (trans-2,4,3',5'-tetrahydroxystilbene) into a potent tyrosinase inhibitor and a strong cytotoxic agent. Bioorg Med Chem Lett. 2006 Nov 1;16(21):5650-3. DMI2PY7 RU https://pubmed.ncbi.nlm.nih.gov/16919455 DMS8I1E DI DMS8I1E DMS8I1E DN 2,4,4-triphenylimidazoline DMS8I1E MI TTY6EWA DMS8I1E MN Neuropeptide Y receptor type 5 (NPY5R) DMS8I1E MT DTT DMS8I1E MA Inhibitor DMS8I1E RN Discovery of substituted 2,4,4-triarylimidazoline derivatives as potent and selective neuropeptide Y Y5 receptor antagonists. Bioorg Med Chem Lett. 2009 Mar 15;19(6):1670-4. DMS8I1E RU https://pubmed.ncbi.nlm.nih.gov/19233647 DMSJBEH DI DMSJBEH DMSJBEH DN 2,4,5-Triarylimidazole analogue DMSJBEH MI TTSJ6Q4 DMSJBEH MN LOX-5 messenger RNA (ALOX5 mRNA) DMSJBEH MT DTT DMSJBEH MA Inhibitor DMSJBEH RN 2,4,5- triarylimidazole inhibitors of IL-1 biosynthesis, Bioorg. Med. Chem. Lett. 5(11):1171-1176 (1995). DMSJBEH RU http://www.sciencedirect.com/science/article/pii/0960894X9500189Z DMTA152 DI DMTA152 DMTA152 DN 2,4,6 trinitrobenzene sulfonate 1,3-bis (2-chlorethyl)-1-nitrosourea DMTA152 MI TTEP6RV DMTA152 MN Glutathione reductase (GR) DMTA152 MT DTT DMTA152 MA Inhibitor DMTA152 RN The purification and properties of glutathione reductase from the cestode Moniezia expansa. Int J Biochem Cell Biol. 1995 Apr;27(4):393-401. DMTA152 RU https://pubmed.ncbi.nlm.nih.gov/7788561 DMTVL9N DI DMTVL9N DMTVL9N DN 2,4,6-Trihydroxy-3-nitro-N-tridecyl-benzamide DMTVL9N MI TTWXB3E DMTVL9N MN Hepatitis C virus NS3 helicase (HCV NS3) DMTVL9N MT DTT DMTVL9N MA Inhibitor DMTVL9N RN Control of hepatitis C: a medicinal chemistry perspective. J Med Chem. 2005 Jan 13;48(1):1-20. DMTVL9N RU https://pubmed.ncbi.nlm.nih.gov/15633995 DM90TSI DI DM90TSI DM90TSI DN 2,4-bis-docosanoylamino-benzenesulfonate DM90TSI MI TT2TDH9 DM90TSI MN Scavenger receptor A1 (MSR1) DM90TSI MT DTT DM90TSI MA Inhibitor DM90TSI RN 2,4-Bis(octadecanoylamino)benzenesulfonic acid sodium salt as a novel scavenger receptor inhibitor with low molecular weight. Bioorg Med Chem Lett. 2004 Jun 7;14(11):2791-5. DM90TSI RU https://pubmed.ncbi.nlm.nih.gov/15125934 DMZO0EI DI DMZO0EI DMZO0EI DN 2,4-Deoxy-4-Guanidino-5-N-Acetyl-Neuraminic Acid DMZO0EI MI TT50QJ3 DMZO0EI MN Influenza Neuraminidase (Influ NA) DMZO0EI MT DTT DMZO0EI MA Inhibitor DMZO0EI RN DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Nucleic Acids Res. 2011 Jan;39(Database issue):D1035-41. DMZO0EI RU https://pubmed.ncbi.nlm.nih.gov/21059682 DMVPWML DI DMVPWML DMVPWML DN 2,4'-Diacetoxy-5,3'-di-(2-propenyl)-biphenyl DMVPWML MI TTSJ6Q4 DMVPWML MN LOX-5 messenger RNA (ALOX5 mRNA) DMVPWML MT DTT DMVPWML MA Inhibitor DMVPWML RN Design and synthesis of ten biphenyl-neolignan derivatives and their in vitro inhibitory potency against cyclooxygenase-1/2 activity and 5-lipoxyge... Bioorg Med Chem. 2009 Jul 1;17(13):4459-65. DMVPWML RU https://pubmed.ncbi.nlm.nih.gov/19481465 DMQPKWM DI DMQPKWM DMQPKWM DN 2,4-Diamino-6-Phenyl-5,6,7,8,-Tetrahydropteridine DMQPKWM MI TTCM4B3 DMQPKWM MN Nitric-oxide synthase endothelial (NOS3) DMQPKWM MT DTT DMQPKWM MA Inhibitor DMQPKWM RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DMQPKWM RU https://pubmed.ncbi.nlm.nih.gov/10592235 DMAOGBP DI DMAOGBP DMAOGBP DN 2,4-Diamino-butyric acid(GABA) DMAOGBP MI TTPRKM0 DMAOGBP MN GABA transporter GAT-1 (SLC6A1) DMAOGBP MT DTT DMAOGBP MA Inhibitor DMAOGBP RN Glycine antagonists. Synthesis, structure, and biological effects of some bicyclic 5-isoxazolol zwitterions. J Med Chem. 1986 Feb;29(2):224-9. DMAOGBP RU https://pubmed.ncbi.nlm.nih.gov/3005567 DMAOGBP DI DMAOGBP DMAOGBP DN 2,4-Diamino-butyric acid(GABA) DMAOGBP MI TT8RXO5 DMAOGBP MN GABA transporter-3 (SLC6A11) DMAOGBP MT DTT DMAOGBP MA Inhibitor DMAOGBP RN Glycine antagonists. Synthesis, structure, and biological effects of some bicyclic 5-isoxazolol zwitterions. J Med Chem. 1986 Feb;29(2):224-9. DMAOGBP RU https://pubmed.ncbi.nlm.nih.gov/3005567 DMAOGBP DI DMAOGBP DMAOGBP DN 2,4-Diamino-butyric acid(GABA) DMAOGBP MI TTNJYV2 DMAOGBP MN Gamma-aminobutyric acid receptor (GAR) DMAOGBP MT DTT DMAOGBP MA Inhibitor DMAOGBP RN Glycine antagonists. Synthesis, structure, and biological effects of some bicyclic 5-isoxazolol zwitterions. J Med Chem. 1986 Feb;29(2):224-9. DMAOGBP RU https://pubmed.ncbi.nlm.nih.gov/3005567 DMS1YXL DI DMS1YXL DMS1YXL DN 2,4-diaminoquinozalines and quinoxaline-2,3-diones DMS1YXL MI TTNSXG2 DMS1YXL MN Human immunodeficiency virus TAR RNA (HIV TAR-RNA) DMS1YXL MT DTT DMS1YXL MA Inhibitor DMS1YXL RN RNA as a target for small molecules. Curr Opin Chem Biol. 2000 Dec;4(6):678-86. DMS1YXL RU https://pubmed.ncbi.nlm.nih.gov/11102874 DMQ385U DI DMQ385U DMQ385U DN 2,4-Dibenzylamino-6-isopentylpyrimidine DMQ385U MI TTZAYWL DMQ385U MN Estrogen receptor (ESR) DMQ385U MT DTT DMQ385U MA Inhibitor DMQ385U RN Blocking estrogen signaling after the hormone: pyrimidine-core inhibitors of estrogen receptor-coactivator binding. J Med Chem. 2008 Oct 23;51(20):6512-30. DMQ385U RU https://pubmed.ncbi.nlm.nih.gov/18785725 DM4EY5S DI DM4EY5S DM4EY5S DN 2,4-dichloro-5-sulfamoylbenzoic acid DM4EY5S MI TTHQPL7 DM4EY5S MN Carbonic anhydrase I (CA-I) DM4EY5S MT DTT DM4EY5S MA Inhibitor DM4EY5S RN Synthesis, characterization and antiglaucoma activity of a novel proton transfer compound and a mixed-ligand Zn(II) complex. Bioorg Med Chem. 2010 Jan 15;18(2):930-8. DM4EY5S RU https://pubmed.ncbi.nlm.nih.gov/20006931 DM4EY5S DI DM4EY5S DM4EY5S DN 2,4-dichloro-5-sulfamoylbenzoic acid DM4EY5S MI TTANPDJ DM4EY5S MN Carbonic anhydrase II (CA-II) DM4EY5S MT DTT DM4EY5S MA Inhibitor DM4EY5S RN Synthesis, characterization and antiglaucoma activity of a novel proton transfer compound and a mixed-ligand Zn(II) complex. Bioorg Med Chem. 2010 Jan 15;18(2):930-8. DM4EY5S RU https://pubmed.ncbi.nlm.nih.gov/20006931 DMR5DYK DI DMR5DYK DMR5DYK DN 2,4-Dichlorobenzenemethanethiol DMR5DYK MI TTZJYKH DMR5DYK MN Indoleamine 2,3-dioxygenase 1 (IDO1) DMR5DYK MT DTT DMR5DYK MA Inhibitor DMR5DYK RN S-benzylisothiourea derivatives as small-molecule inhibitors of indoleamine-2,3-dioxygenase. Bioorg Med Chem Lett. 2010 Sep 1;20(17):5126-9. DMR5DYK RU https://pubmed.ncbi.nlm.nih.gov/20688518 DMO4FSH DI DMO4FSH DMO4FSH DN 2,4-Dichloro-N-(4-phenyl-thiazol-2-yl)-benzamide DMO4FSH MI TTK25J1 DMO4FSH MN Adenosine A1 receptor (ADORA1) DMO4FSH MT DTT DMO4FSH MA Inhibitor DMO4FSH RN Substituted 4-phenyl-2-(phenylcarboxamido)-1,3-thiazole derivatives as antagonists for the adenosine A(1) receptor. Bioorg Med Chem Lett. 2001 Aug 6;11(15):2017-9. DMO4FSH RU https://pubmed.ncbi.nlm.nih.gov/11454470 DM4QDZV DI DM4QDZV DM4QDZV DN 2',4'-dicyanobiphenyl-4-yl sulfamate DM4QDZV MI TTHM0R1 DM4QDZV MN Steryl-sulfatase (STS) DM4QDZV MT DTT DM4QDZV MA Inhibitor DM4QDZV RN Highly potent first examples of dual aromatase-steroid sulfatase inhibitors based on a biphenyl template. J Med Chem. 2010 Mar 11;53(5):2155-70. DM4QDZV RU https://pubmed.ncbi.nlm.nih.gov/20148564 DM75TJ1 DI DM75TJ1 DM75TJ1 DN 2,4-difluorophenyl 4-butoxybenzylcarbamate DM75TJ1 MI TTDP1UC DM75TJ1 MN Fatty acid amide hydrolase (FAAH) DM75TJ1 MT DTT DM75TJ1 MA Inhibitor DM75TJ1 RN Oxime carbamate--discovery of a series of novel FAAH inhibitors. Bioorg Med Chem Lett. 2010 Feb 1;20(3):1272-7. DM75TJ1 RU https://pubmed.ncbi.nlm.nih.gov/20036536 DM0URFY DI DM0URFY DM0URFY DN 2,4-diisobutylamino-6-isopentylpyrimidine DM0URFY MI TTZAYWL DM0URFY MN Estrogen receptor (ESR) DM0URFY MT DTT DM0URFY MA Inhibitor DM0URFY RN Blocking estrogen signaling after the hormone: pyrimidine-core inhibitors of estrogen receptor-coactivator binding. J Med Chem. 2008 Oct 23;51(20):6512-30. DM0URFY RU https://pubmed.ncbi.nlm.nih.gov/18785725 DMP9BZU DI DMP9BZU DMP9BZU DN 2,4-dimethoxy-2'-hydroxychalcone DMP9BZU MI TTVKILB DMP9BZU MN Prostaglandin G/H synthase 2 (COX-2) DMP9BZU MT DTT DMP9BZU MA Inhibitor DMP9BZU RN Inhibitory activity of prostaglandin E2 production by the synthetic 2'-hydroxychalcone analogues: Synthesis and SAR study. Bioorg Med Chem Lett. 2009 Mar 15;19(6):1650-3. DMP9BZU RU https://pubmed.ncbi.nlm.nih.gov/19233646 DMHSLXI DI DMHSLXI DMHSLXI DN 2,4-Dimethoxy-3'-amino-trans-stilbene DMHSLXI MI TTSZLWK DMHSLXI MN Aromatase (CYP19A1) DMHSLXI MT DTT DMHSLXI MA Inhibitor DMHSLXI RN Design, synthesis, and biological evaluation of resveratrol analogues as aromatase and quinone reductase 2 inhibitors for chemoprevention of cancer. Bioorg Med Chem. 2010 Jul 15;18(14):5352-66. DMHSLXI RU https://pubmed.ncbi.nlm.nih.gov/20558073 DMMZ643 DI DMMZ643 DMMZ643 DN 2,4-Dimethoxy-4'-amino-trans-stilbene DMMZ643 MI TTSZLWK DMMZ643 MN Aromatase (CYP19A1) DMMZ643 MT DTT DMMZ643 MA Inhibitor DMMZ643 RN Design, synthesis, and biological evaluation of resveratrol analogues as aromatase and quinone reductase 2 inhibitors for chemoprevention of cancer. Bioorg Med Chem. 2010 Jul 15;18(14):5352-66. DMMZ643 RU https://pubmed.ncbi.nlm.nih.gov/20558073 DMWNJ84 DI DMWNJ84 DMWNJ84 DN 2,4'-Dimethoxy-5,3'-di-(2-propenyl)-biphenyl DMWNJ84 MI TTSJ6Q4 DMWNJ84 MN LOX-5 messenger RNA (ALOX5 mRNA) DMWNJ84 MT DTT DMWNJ84 MA Inhibitor DMWNJ84 RN Design and synthesis of ten biphenyl-neolignan derivatives and their in vitro inhibitory potency against cyclooxygenase-1/2 activity and 5-lipoxyge... Bioorg Med Chem. 2009 Jul 1;17(13):4459-65. DMWNJ84 RU https://pubmed.ncbi.nlm.nih.gov/19481465 DMWNJ84 DI DMWNJ84 DMWNJ84 DN 2,4'-Dimethoxy-5,3'-di-(2-propenyl)-biphenyl DMWNJ84 MI TT8NGED DMWNJ84 MN Prostaglandin G/H synthase 1 (COX-1) DMWNJ84 MT DTT DMWNJ84 MA Inhibitor DMWNJ84 RN Design and synthesis of ten biphenyl-neolignan derivatives and their in vitro inhibitory potency against cyclooxygenase-1/2 activity and 5-lipoxyge... Bioorg Med Chem. 2009 Jul 1;17(13):4459-65. DMWNJ84 RU https://pubmed.ncbi.nlm.nih.gov/19481465 DMWNJ84 DI DMWNJ84 DMWNJ84 DN 2,4'-Dimethoxy-5,3'-di-(2-propenyl)-biphenyl DMWNJ84 MI TTVKILB DMWNJ84 MN Prostaglandin G/H synthase 2 (COX-2) DMWNJ84 MT DTT DMWNJ84 MA Inhibitor DMWNJ84 RN Design and synthesis of ten biphenyl-neolignan derivatives and their in vitro inhibitory potency against cyclooxygenase-1/2 activity and 5-lipoxyge... Bioorg Med Chem. 2009 Jul 1;17(13):4459-65. DMWNJ84 RU https://pubmed.ncbi.nlm.nih.gov/19481465 DM94NM7 DI DM94NM7 DM94NM7 DN 2,4'-Dimethoxy-5,3'-dipropyl-biphenyl DM94NM7 MI TTVKILB DM94NM7 MN Prostaglandin G/H synthase 2 (COX-2) DM94NM7 MT DTT DM94NM7 MA Inhibitor DM94NM7 RN Design and synthesis of ten biphenyl-neolignan derivatives and their in vitro inhibitory potency against cyclooxygenase-1/2 activity and 5-lipoxyge... Bioorg Med Chem. 2009 Jul 1;17(13):4459-65. DM94NM7 RU https://pubmed.ncbi.nlm.nih.gov/19481465 DM2AW0Z DI DM2AW0Z DM2AW0Z DN 2,4-Disulfamyltrifluoromethylaniline DM2AW0Z MI TTUNARX DM2AW0Z MN Carbonic anhydrase (CA) DM2AW0Z MT DTT DM2AW0Z MA Inhibitor DM2AW0Z RN Cloning, expression, post-translational modifications and inhibition studies on the latest mammalian carbonic anhydrase isoform, CA XV. J Med Chem. 2009 Feb 12;52(3):646-54. DM2AW0Z RU https://pubmed.ncbi.nlm.nih.gov/19193158 DM2AW0Z DI DM2AW0Z DM2AW0Z DN 2,4-Disulfamyltrifluoromethylaniline DM2AW0Z MI TTHQPL7 DM2AW0Z MN Carbonic anhydrase I (CA-I) DM2AW0Z MT DTT DM2AW0Z MA Inhibitor DM2AW0Z RN Carbonic anhydrase inhibitors. Inhibition studies of a coral secretory isoform by sulfonamides. Bioorg Med Chem. 2009 Jul 15;17(14):5054-8. DM2AW0Z RU https://pubmed.ncbi.nlm.nih.gov/19520577 DM2AW0Z DI DM2AW0Z DM2AW0Z DN 2,4-Disulfamyltrifluoromethylaniline DM2AW0Z MI TTANPDJ DM2AW0Z MN Carbonic anhydrase II (CA-II) DM2AW0Z MT DTT DM2AW0Z MA Inhibitor DM2AW0Z RN Carbonic anhydrase inhibitors. Characterization and inhibition studies of the most active beta-carbonic anhydrase from Mycobacterium tuberculosis, ... Bioorg Med Chem Lett. 2009 Dec 1;19(23):6649-54. DM2AW0Z RU https://pubmed.ncbi.nlm.nih.gov/19846301 DM2AW0Z DI DM2AW0Z DM2AW0Z DN 2,4-Disulfamyltrifluoromethylaniline DM2AW0Z MI TTZHA0O DM2AW0Z MN Carbonic anhydrase IV (CA-IV) DM2AW0Z MT DTT DM2AW0Z MA Inhibitor DM2AW0Z RN Carbonic anhydrase inhibitors. Inhibition of the membrane-bound human and bovine isozymes IV with sulfonamides. Bioorg Med Chem Lett. 2005 Feb 15;15(4):1149-54. DM2AW0Z RU https://pubmed.ncbi.nlm.nih.gov/15686931 DM2AW0Z DI DM2AW0Z DM2AW0Z DN 2,4-Disulfamyltrifluoromethylaniline DM2AW0Z MI TT2LVK8 DM2AW0Z MN Carbonic anhydrase IX (CA-IX) DM2AW0Z MT DTT DM2AW0Z MA Inhibitor DM2AW0Z RN Cloning, expression, post-translational modifications and inhibition studies on the latest mammalian carbonic anhydrase isoform, CA XV. J Med Chem. 2009 Feb 12;52(3):646-54. DM2AW0Z RU https://pubmed.ncbi.nlm.nih.gov/19193158 DM2AW0Z DI DM2AW0Z DM2AW0Z DN 2,4-Disulfamyltrifluoromethylaniline DM2AW0Z MI TTCFSPE DM2AW0Z MN Carbonic anhydrase VI (CA-VI) DM2AW0Z MT DTT DM2AW0Z MA Inhibitor DM2AW0Z RN Cloning, expression, post-translational modifications and inhibition studies on the latest mammalian carbonic anhydrase isoform, CA XV. J Med Chem. 2009 Feb 12;52(3):646-54. DM2AW0Z RU https://pubmed.ncbi.nlm.nih.gov/19193158 DM2AW0Z DI DM2AW0Z DM2AW0Z DN 2,4-Disulfamyltrifluoromethylaniline DM2AW0Z MI TTSYM0R DM2AW0Z MN Carbonic anhydrase XII (CA-XII) DM2AW0Z MT DTT DM2AW0Z MA Inhibitor DM2AW0Z RN Carbonic anhydrase inhibitors. Inhibition of the transmembrane isozyme XII with sulfonamides-a new target for the design of antitumor and antiglauc... Bioorg Med Chem Lett. 2005 Feb 15;15(4):963-9. DM2AW0Z RU https://pubmed.ncbi.nlm.nih.gov/15686894 DM2AW0Z DI DM2AW0Z DM2AW0Z DN 2,4-Disulfamyltrifluoromethylaniline DM2AW0Z MI TTEYTKG DM2AW0Z MN Carbonic anhydrase XIV (CA-XIV) DM2AW0Z MT DTT DM2AW0Z MA Inhibitor DM2AW0Z RN Carbonic anhydrase inhibitors: inhibition of the transmembrane isozyme XIV with sulfonamides. Bioorg Med Chem Lett. 2005 Sep 1;15(17):3828-33. DM2AW0Z RU https://pubmed.ncbi.nlm.nih.gov/16039848 DMZRY0Q DI DMZRY0Q DMZRY0Q DN 2,4-epi-neodysiherbaine DMZRY0Q MI TT0MYE2 DMZRY0Q MN Glutamate receptor ionotropic kainate 1 (GRIK1) DMZRY0Q MT DTT DMZRY0Q MA Antagonist DMZRY0Q RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 450). DMZRY0Q RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=450 DMZRY0Q DI DMZRY0Q DMZRY0Q DN 2,4-epi-neodysiherbaine DMZRY0Q MI TT0K5RG DMZRY0Q MN Glutamate receptor ionotropic kainate 2 (GRIK2) DMZRY0Q MT DTT DMZRY0Q MA Antagonist DMZRY0Q RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 451). DMZRY0Q RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=451 DMLDHMB DI DMLDHMB DMLDHMB DN 2,5-Anhydroglucitol-1,6-Biphosphate DMLDHMB MI TTWHDVK DMLDHMB MN Fructose-1,6-bisphosphatase (FBP) DMLDHMB MT DTT DMLDHMB MA Inhibitor DMLDHMB RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMLDHMB RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMU5GKN DI DMU5GKN DMU5GKN DN 2,5-bis(2-methoxyphenyl)thiophene DMU5GKN MI TTE4KHA DMU5GKN MN Amyloid beta A4 protein (APP) DMU5GKN MT DTT DMU5GKN MA Inhibitor DMU5GKN RN Design, synthesis, and structure-activity relationship of novel thiophene derivatives for beta-amyloid plaque imaging. Bioorg Med Chem Lett. 2006 Mar 1;16(5):1350-2. DMU5GKN RU https://pubmed.ncbi.nlm.nih.gov/16325402 DMH6RDL DI DMH6RDL DMH6RDL DN 2,5-Bis-(3,4-dimethoxy-phenyl)-furan DMH6RDL MI TTZ97H5 DMH6RDL MN Phosphodiesterase 4A (PDE4A) DMH6RDL MT DTT DMH6RDL MA Inhibitor DMH6RDL RN Substituted furans as inhibitors of the PDE4 enzyme. Bioorg Med Chem Lett. 1999 Feb 8;9(3):323-6. DMH6RDL RU https://pubmed.ncbi.nlm.nih.gov/10091677 DM28GQS DI DM28GQS DM28GQS DN 2,5-Bis-(3-cyclopentyloxy-4-methoxy-phenyl)-furan DM28GQS MI TTZ97H5 DM28GQS MN Phosphodiesterase 4A (PDE4A) DM28GQS MT DTT DM28GQS MA Inhibitor DM28GQS RN Substituted furans as inhibitors of the PDE4 enzyme. Bioorg Med Chem Lett. 1999 Feb 8;9(3):323-6. DM28GQS RU https://pubmed.ncbi.nlm.nih.gov/10091677 DMOQPHK DI DMOQPHK DMOQPHK DN 2,5-bis(4-hydroxybenzylidene)cyclopentanone DMOQPHK MI TTXV4FI DMOQPHK MN Albendazole monooxygenase (CYP3A4) DMOQPHK MT DTT DMOQPHK MA Inhibitor DMOQPHK RN Structure-activity relationships for the inhibition of recombinant human cytochromes P450 by curcumin analogues. Eur J Med Chem. 2008 Aug;43(8):1621-31. DMOQPHK RU https://pubmed.ncbi.nlm.nih.gov/18249473 DMNQIGZ DI DMNQIGZ DMNQIGZ DN 2,5-bis(4-Hydroxyphenyl)thiophene DMNQIGZ MI TTE4KHA DMNQIGZ MN Amyloid beta A4 protein (APP) DMNQIGZ MT DTT DMNQIGZ MA Inhibitor DMNQIGZ RN Design, synthesis, and structure-activity relationship of novel thiophene derivatives for beta-amyloid plaque imaging. Bioorg Med Chem Lett. 2006 Mar 1;16(5):1350-2. DMNQIGZ RU https://pubmed.ncbi.nlm.nih.gov/16325402 DM30RNY DI DM30RNY DM30RNY DN 2,5-bis(4-methoxyphenyl)thiophene DM30RNY MI TTE4KHA DM30RNY MN Amyloid beta A4 protein (APP) DM30RNY MT DTT DM30RNY MA Inhibitor DM30RNY RN Design, synthesis, and structure-activity relationship of novel thiophene derivatives for beta-amyloid plaque imaging. Bioorg Med Chem Lett. 2006 Mar 1;16(5):1350-2. DM30RNY RU https://pubmed.ncbi.nlm.nih.gov/16325402 DM3USOR DI DM3USOR DM3USOR DN 2,5-bis(4-nitrophenyl)thiophene DM3USOR MI TTE4KHA DM3USOR MN Amyloid beta A4 protein (APP) DM3USOR MT DTT DM3USOR MA Inhibitor DM3USOR RN Design, synthesis, and structure-activity relationship of novel thiophene derivatives for beta-amyloid plaque imaging. Bioorg Med Chem Lett. 2006 Mar 1;16(5):1350-2. DM3USOR RU https://pubmed.ncbi.nlm.nih.gov/16325402 DMMESIU DI DMMESIU DMMESIU DN 2,5'-dichloro-5'-deoxy-N6-cyclopentyladenosine DMMESIU MI TTK25J1 DMMESIU MN Adenosine A1 receptor (ADORA1) DMMESIU MT DTT DMMESIU MA Inhibitor DMMESIU RN N6-Cycloalkyl- and N6-bicycloalkyl-C5'(C2')-modified adenosine derivatives as high-affinity and selective agonists at the human A1 adenosine recept... J Med Chem. 2009 Apr 23;52(8):2393-406. DMMESIU RU https://pubmed.ncbi.nlm.nih.gov/19317449 DMMESIU DI DMMESIU DMMESIU DN 2,5'-dichloro-5'-deoxy-N6-cyclopentyladenosine DMMESIU MI TTM2AOE DMMESIU MN Adenosine A2a receptor (ADORA2A) DMMESIU MT DTT DMMESIU MA Inhibitor DMMESIU RN N6-Cycloalkyl- and N6-bicycloalkyl-C5'(C2')-modified adenosine derivatives as high-affinity and selective agonists at the human A1 adenosine recept... J Med Chem. 2009 Apr 23;52(8):2393-406. DMMESIU RU https://pubmed.ncbi.nlm.nih.gov/19317449 DMMESIU DI DMMESIU DMMESIU DN 2,5'-dichloro-5'-deoxy-N6-cyclopentyladenosine DMMESIU MI TTNE7KG DMMESIU MN Adenosine A2b receptor (ADORA2B) DMMESIU MT DTT DMMESIU MA Inhibitor DMMESIU RN N6-Cycloalkyl- and N6-bicycloalkyl-C5'(C2')-modified adenosine derivatives as high-affinity and selective agonists at the human A1 adenosine recept... J Med Chem. 2009 Apr 23;52(8):2393-406. DMMESIU RU https://pubmed.ncbi.nlm.nih.gov/19317449 DMMESIU DI DMMESIU DMMESIU DN 2,5'-dichloro-5'-deoxy-N6-cyclopentyladenosine DMMESIU MI TTJFY5U DMMESIU MN Adenosine A3 receptor (ADORA3) DMMESIU MT DTT DMMESIU MA Inhibitor DMMESIU RN N6-Cycloalkyl- and N6-bicycloalkyl-C5'(C2')-modified adenosine derivatives as high-affinity and selective agonists at the human A1 adenosine recept... J Med Chem. 2009 Apr 23;52(8):2393-406. DMMESIU RU https://pubmed.ncbi.nlm.nih.gov/19317449 DM9PK1R DI DM9PK1R DM9PK1R DN 2,5-dichloro-N-phenylthiophene-3-sulfonamide DM9PK1R MI TTSFWA7 DM9PK1R MN Plasmodium CDK Pfmrk (Malaria Pfmrk) DM9PK1R MT DTT DM9PK1R MA Inhibitor DM9PK1R RN Activity of substituted thiophene sulfonamides against malarial and mammalian cyclin dependent protein kinases, Bioorg. Med. Chem. Lett. 20(13):3863-3867 (2010). DM9PK1R RU http://www.sciencedirect.com/science/article/pii/S0960894X10006803 DMU5J8Y DI DMU5J8Y DMU5J8Y DN 2,5-dichloro-N-p-tolylthiophene-3-sulfonamide DMU5J8Y MI TTAMQ62 DMU5J8Y MN Cyclin A2 (CCNA2) DMU5J8Y MT DTT DMU5J8Y MA Inhibitor DMU5J8Y RN Activity of substituted thiophene sulfonamides against malarial and mammalian cyclin dependent protein kinases, Bioorg. Med. Chem. Lett. 20(13):3863-3867 (2010). DMU5J8Y RU http://www.sciencedirect.com/science/article/pii/S0960894X10006803 DMU5J8Y DI DMU5J8Y DMU5J8Y DN 2,5-dichloro-N-p-tolylthiophene-3-sulfonamide DMU5J8Y MI TTQYF7G DMU5J8Y MN Cyclin-dependent kinase 7 (CDK7) DMU5J8Y MT DTT DMU5J8Y MA Inhibitor DMU5J8Y RN Activity of substituted thiophene sulfonamides against malarial and mammalian cyclin dependent protein kinases, Bioorg. Med. Chem. Lett. 20(13):3863-3867 (2010). DMU5J8Y RU http://www.sciencedirect.com/science/article/pii/S0960894X10006803 DMU5J8Y DI DMU5J8Y DMU5J8Y DN 2,5-dichloro-N-p-tolylthiophene-3-sulfonamide DMU5J8Y MI TTSFWA7 DMU5J8Y MN Plasmodium CDK Pfmrk (Malaria Pfmrk) DMU5J8Y MT DTT DMU5J8Y MA Inhibitor DMU5J8Y RN Activity of substituted thiophene sulfonamides against malarial and mammalian cyclin dependent protein kinases, Bioorg. Med. Chem. Lett. 20(13):3863-3867 (2010). DMU5J8Y RU http://www.sciencedirect.com/science/article/pii/S0960894X10006803 DMI1O54 DI DMI1O54 DMI1O54 DN 2,5-dideoxy-2,5-imino-D-altritol DMI1O54 MI TTIS03D DMI1O54 MN Alpha-galactosidase A (GLA) DMI1O54 MT DTT DMI1O54 MA Inhibitor DMI1O54 RN 2,5-Dideoxy-2,5-imino-d-altritol as a new class of pharmacological chaperone for Fabry disease. Bioorg Med Chem. 2010 Jun 1;18(11):3790-4. DMI1O54 RU https://pubmed.ncbi.nlm.nih.gov/20457528 DMI1O54 DI DMI1O54 DMI1O54 DN 2,5-dideoxy-2,5-imino-D-altritol DMI1O54 MI TTA0OSE DMI1O54 MN Lactase-phlorizin hydrolase (LCT) DMI1O54 MT DTT DMI1O54 MA Inhibitor DMI1O54 RN 2,5-Dideoxy-2,5-imino-d-altritol as a new class of pharmacological chaperone for Fabry disease. Bioorg Med Chem. 2010 Jun 1;18(11):3790-4. DMI1O54 RU https://pubmed.ncbi.nlm.nih.gov/20457528 DMKP7O0 DI DMKP7O0 DMKP7O0 DN 2,5-dideoxy-2,5-imino-dl-glycero-D-manno-heptitol DMKP7O0 MI TTA0OSE DMKP7O0 MN Lactase-phlorizin hydrolase (LCT) DMKP7O0 MT DTT DMKP7O0 MA Inhibitor DMKP7O0 RN Nitrogen-containing furanose and pyranose analogues from Hyacinthus orientalis. J Nat Prod. 1998 May;61(5):625-8. DMKP7O0 RU https://pubmed.ncbi.nlm.nih.gov/9599261 DMGQVF5 DI DMGQVF5 DMGQVF5 DN 2,5-Dideoxy-2,5-imino-D-mannitol DMGQVF5 MI TTXWASR DMGQVF5 MN Intestinal maltase-glucoamylase (MGAM) DMGQVF5 MT DTT DMGQVF5 MA Inhibitor DMGQVF5 RN New sugar-mimic alkaloids from the pods of Angylocalyx pynaertii. J Nat Prod. 2002 Feb;65(2):198-202. DMGQVF5 RU https://pubmed.ncbi.nlm.nih.gov/11858756 DM5OYWF DI DM5OYWF DM5OYWF DN 2',5'-DIDEOXY-ADENOSINE 3'-MONOPHOSPHATE DM5OYWF MI TTBQ9IM DM5OYWF MN Adenylate cyclase type 2 (ADCY2) DM5OYWF MT DTT DM5OYWF MA Inhibitor DM5OYWF RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DM5OYWF RU https://pubmed.ncbi.nlm.nih.gov/10592235 DM5CWM0 DI DM5CWM0 DM5CWM0 DN 2,5-didesoxy-3-ATP DM5CWM0 MI TT2QM9D DM5CWM0 MN Adenylate cyclase (ADCY) DM5CWM0 MT DTT DM5CWM0 MA Inhibitor DM5CWM0 RN Structure-based development of novel adenylyl cyclase inhibitors. J Med Chem. 2008 Aug 14;51(15):4456-64. DM5CWM0 RU https://pubmed.ncbi.nlm.nih.gov/18630896 DMIGFX6 DI DMIGFX6 DMIGFX6 DN 2,5-difluorophenol DMIGFX6 MI TTUNARX DMIGFX6 MN Carbonic anhydrase (CA) DMIGFX6 MT DTT DMIGFX6 MA Inhibitor DMIGFX6 RN Carbonic anhydrase inhibitors: inhibition of mammalian isoforms I-XIV with a series of substituted phenols including paracetamol and salicylic acid. Bioorg Med Chem. 2008 Aug 1;16(15):7424-8. DMIGFX6 RU https://pubmed.ncbi.nlm.nih.gov/18579385 DMV0UIR DI DMV0UIR DMV0UIR DN 2,5-Dimethoxy-4'-amino-trans-stilbene DMV0UIR MI TTSZLWK DMV0UIR MN Aromatase (CYP19A1) DMV0UIR MT DTT DMV0UIR MA Inhibitor DMV0UIR RN Design, synthesis, and biological evaluation of resveratrol analogues as aromatase and quinone reductase 2 inhibitors for chemoprevention of cancer. Bioorg Med Chem. 2010 Jul 15;18(14):5352-66. DMV0UIR RU https://pubmed.ncbi.nlm.nih.gov/20558073 DM50ZQP DI DM50ZQP DM50ZQP DN 2,5-dimethoxy-4-bromophenethylamine DM50ZQP MI TTJQOD7 DM50ZQP MN 5-HT 2A receptor (HTR2A) DM50ZQP MT DTT DM50ZQP MA Inhibitor DM50ZQP RN 1-Aminomethylbenzocycloalkanes: conformationally restricted hallucinogenic phenethylamine analogues as functionally selective 5-HT2A receptor agoni... J Med Chem. 2006 Sep 21;49(19):5794-803. DM50ZQP RU https://pubmed.ncbi.nlm.nih.gov/16970404 DM5IJSW DI DM5IJSW DM5IJSW DN 2,5-imino-2,5,6-trideoxy-D-manno-heptitol DM5IJSW MI TTLPC70 DM5IJSW MN Lysosomal alpha-glucosidase (GAA) DM5IJSW MT DTT DM5IJSW MA Inhibitor DM5IJSW RN Nitrogen-containing furanose and pyranose analogues from Hyacinthus orientalis. J Nat Prod. 1998 May;61(5):625-8. DM5IJSW RU https://pubmed.ncbi.nlm.nih.gov/9599261 DM4IFPQ DI DM4IFPQ DM4IFPQ DN 2,6,8-triphenyl-9H-purine DM4IFPQ MI TTK25J1 DM4IFPQ MN Adenosine A1 receptor (ADORA1) DM4IFPQ MT DTT DM4IFPQ MA Inhibitor DM4IFPQ RN 2,6-disubstituted and 2,6,8-trisubstituted purines as adenosine receptor antagonists. J Med Chem. 2006 May 18;49(10):2861-7. DM4IFPQ RU https://pubmed.ncbi.nlm.nih.gov/16686529 DM4IFPQ DI DM4IFPQ DM4IFPQ DN 2,6,8-triphenyl-9H-purine DM4IFPQ MI TTM2AOE DM4IFPQ MN Adenosine A2a receptor (ADORA2A) DM4IFPQ MT DTT DM4IFPQ MA Inhibitor DM4IFPQ RN 2,6-disubstituted and 2,6,8-trisubstituted purines as adenosine receptor antagonists. J Med Chem. 2006 May 18;49(10):2861-7. DM4IFPQ RU https://pubmed.ncbi.nlm.nih.gov/16686529 DM4IFPQ DI DM4IFPQ DM4IFPQ DN 2,6,8-triphenyl-9H-purine DM4IFPQ MI TTJFY5U DM4IFPQ MN Adenosine A3 receptor (ADORA3) DM4IFPQ MT DTT DM4IFPQ MA Inhibitor DM4IFPQ RN 2,6-disubstituted and 2,6,8-trisubstituted purines as adenosine receptor antagonists. J Med Chem. 2006 May 18;49(10):2861-7. DM4IFPQ RU https://pubmed.ncbi.nlm.nih.gov/16686529 DMYQNK0 DI DMYQNK0 DMYQNK0 DN 2,6-bis(4-chlorophenyl)-9H-purine DMYQNK0 MI TTJFY5U DMYQNK0 MN Adenosine A3 receptor (ADORA3) DMYQNK0 MT DTT DMYQNK0 MA Inhibitor DMYQNK0 RN 2,6-disubstituted and 2,6,8-trisubstituted purines as adenosine receptor antagonists. J Med Chem. 2006 May 18;49(10):2861-7. DMYQNK0 RU https://pubmed.ncbi.nlm.nih.gov/16686529 DMC2N80 DI DMC2N80 DMC2N80 DN 2,6-bis(4-methoxyphenyl)-9H-purine DMC2N80 MI TTJFY5U DMC2N80 MN Adenosine A3 receptor (ADORA3) DMC2N80 MT DTT DMC2N80 MA Inhibitor DMC2N80 RN 2,6-disubstituted and 2,6,8-trisubstituted purines as adenosine receptor antagonists. J Med Chem. 2006 May 18;49(10):2861-7. DMC2N80 RU https://pubmed.ncbi.nlm.nih.gov/16686529 DM41RZX DI DM41RZX DM41RZX DN 2,6-bis(4-tolyl)-9H-purine DM41RZX MI TTK25J1 DM41RZX MN Adenosine A1 receptor (ADORA1) DM41RZX MT DTT DM41RZX MA Inhibitor DM41RZX RN 2,6-disubstituted and 2,6,8-trisubstituted purines as adenosine receptor antagonists. J Med Chem. 2006 May 18;49(10):2861-7. DM41RZX RU https://pubmed.ncbi.nlm.nih.gov/16686529 DM41RZX DI DM41RZX DM41RZX DN 2,6-bis(4-tolyl)-9H-purine DM41RZX MI TTJFY5U DM41RZX MN Adenosine A3 receptor (ADORA3) DM41RZX MT DTT DM41RZX MA Inhibitor DM41RZX RN 2,6-disubstituted and 2,6,8-trisubstituted purines as adenosine receptor antagonists. J Med Chem. 2006 May 18;49(10):2861-7. DM41RZX RU https://pubmed.ncbi.nlm.nih.gov/16686529 DMREF31 DI DMREF31 DMREF31 DN 2,6-diamino-5-nitropyrimidin-4(3H)-one DMREF31 MI TT4ILYC DMREF31 MN Bacterial Dihydropteroate synthetase (Bact folP) DMREF31 MT DTT DMREF31 MA Inhibitor DMREF31 RN Structural studies of pterin-based inhibitors of dihydropteroate synthase. J Med Chem. 2010 Jan 14;53(1):166-77. DMREF31 RU https://pubmed.ncbi.nlm.nih.gov/19899766 DM4RS9N DI DM4RS9N DM4RS9N DN 2,6-diamino-5-nitrosopyrimidin-4(3H)-one DM4RS9N MI TT4ILYC DM4RS9N MN Bacterial Dihydropteroate synthetase (Bact folP) DM4RS9N MT DTT DM4RS9N MA Inhibitor DM4RS9N RN Structural studies of pterin-based inhibitors of dihydropteroate synthase. J Med Chem. 2010 Jan 14;53(1):166-77. DM4RS9N RU https://pubmed.ncbi.nlm.nih.gov/19899766 DM8JFNU DI DM8JFNU DM8JFNU DN 2,6-DICARBOXYNAPHTHALENE DM8JFNU MI TTQO71U DM8JFNU MN Hemoglobin (HB) DM8JFNU MT DTT DM8JFNU MA Inhibitor DM8JFNU RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DM8JFNU RU https://pubmed.ncbi.nlm.nih.gov/10592235 DMGEYAK DI DMGEYAK DMGEYAK DN 2,6-Difluorobenzenesulfonamide DMGEYAK MI TTANPDJ DMGEYAK MN Carbonic anhydrase II (CA-II) DMGEYAK MT DTT DMGEYAK MA Inhibitor DMGEYAK RN DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Nucleic Acids Res. 2011 Jan;39(Database issue):D1035-41. DMGEYAK RU https://pubmed.ncbi.nlm.nih.gov/21059682 DMDN12L DI DMDN12L DMDN12L DN 2,6-Dihydroanthra/1,9-Cd/Pyrazol-6-One DMDN12L MI TTP7EGM DMDN12L MN Dual specificity protein kinase TTK (MPS1) DMDN12L MT DTT DMDN12L MA Inhibitor DMDN12L RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMDN12L RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMDN12L DI DMDN12L DMDN12L DN 2,6-Dihydroanthra/1,9-Cd/Pyrazol-6-One DMDN12L MI TTR2TXZ DMDN12L MN Jun N terminal kinase (JNK) DMDN12L MT DTT DMDN12L MA Inhibitor DMDN12L RN c-Jun N-terminal kinase is required for metalloproteinase expression and joint destruction in inflammatory arthritis. J Clin Invest. 2001 Jul;108(1):73-81. DMDN12L RU https://pubmed.ncbi.nlm.nih.gov/11435459 DMDN12L DI DMDN12L DMDN12L DN 2,6-Dihydroanthra/1,9-Cd/Pyrazol-6-One DMDN12L MI TT0K6EO DMDN12L MN Stress-activated protein kinase JNK1 (JNK1) DMDN12L MT DTT DMDN12L MA Inhibitor DMDN12L RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMDN12L RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMDN12L DI DMDN12L DMDN12L DN 2,6-Dihydroanthra/1,9-Cd/Pyrazol-6-One DMDN12L MI TTHS0U8 DMDN12L MN Stress-activated protein kinase JNK2 (JNK2) DMDN12L MT DTT DMDN12L MA Inhibitor DMDN12L RN Pharmacological inhibitors of MAPK pathways. Trends Pharmacol Sci. 2002 Jan;23(1):40-5. DMDN12L RU https://pubmed.ncbi.nlm.nih.gov/11804650 DMDN12L DI DMDN12L DMDN12L DN 2,6-Dihydroanthra/1,9-Cd/Pyrazol-6-One DMDN12L MI TT056SO DMDN12L MN Stress-activated protein kinase JNK3 (JNK3) DMDN12L MT DTT DMDN12L MA Inhibitor DMDN12L RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMDN12L RU https://pubmed.ncbi.nlm.nih.gov/17139284 DM5QEUC DI DM5QEUC DM5QEUC DN 2,6-dihydroxy-1,7-dimethoxyxanthone DM5QEUC MI TTVKILB DM5QEUC MN Prostaglandin G/H synthase 2 (COX-2) DM5QEUC MT DTT DM5QEUC MA Inhibitor DM5QEUC RN Selective cyclooxygenase-2 inhibitors from Calophyllum membranaceum. J Nat Prod. 2005 Oct;68(10):1514-8. DM5QEUC RU https://pubmed.ncbi.nlm.nih.gov/16252917 DMD51I4 DI DMD51I4 DMD51I4 DN 2,6-Diisopropyl-4-nitro-phenol DMD51I4 MI TTNJYV2 DMD51I4 MN Gamma-aminobutyric acid receptor (GAR) DMD51I4 MT DTT DMD51I4 MA Inhibitor DMD51I4 RN Propofol analogues. Synthesis, relationships between structure and affinity at GABAA receptor in rat brain, and differential electrophysiological p... J Med Chem. 1998 May 21;41(11):1846-54. DMD51I4 RU https://pubmed.ncbi.nlm.nih.gov/9599235 DMRZJU5 DI DMRZJU5 DMRZJU5 DN 2,6-dimethyl-8-ethyl-1-deazapurine DMRZJU5 MI TTK25J1 DMRZJU5 MN Adenosine A1 receptor (ADORA1) DMRZJU5 MT DTT DMRZJU5 MA Inhibitor DMRZJU5 RN 2,6,8-trisubstituted 1-deazapurines as adenosine receptor antagonists. J Med Chem. 2007 Feb 22;50(4):828-34. DMRZJU5 RU https://pubmed.ncbi.nlm.nih.gov/17300165 DMW2VZ1 DI DMW2VZ1 DMW2VZ1 DN 2,6-diphenyl-1-deazapurine DMW2VZ1 MI TTK25J1 DMW2VZ1 MN Adenosine A1 receptor (ADORA1) DMW2VZ1 MT DTT DMW2VZ1 MA Inhibitor DMW2VZ1 RN 2,6,8-trisubstituted 1-deazapurines as adenosine receptor antagonists. J Med Chem. 2007 Feb 22;50(4):828-34. DMW2VZ1 RU https://pubmed.ncbi.nlm.nih.gov/17300165 DMW2VZ1 DI DMW2VZ1 DMW2VZ1 DN 2,6-diphenyl-1-deazapurine DMW2VZ1 MI TTM2AOE DMW2VZ1 MN Adenosine A2a receptor (ADORA2A) DMW2VZ1 MT DTT DMW2VZ1 MA Inhibitor DMW2VZ1 RN 2,6,8-trisubstituted 1-deazapurines as adenosine receptor antagonists. J Med Chem. 2007 Feb 22;50(4):828-34. DMW2VZ1 RU https://pubmed.ncbi.nlm.nih.gov/17300165 DMW2VZ1 DI DMW2VZ1 DMW2VZ1 DN 2,6-diphenyl-1-deazapurine DMW2VZ1 MI TTJFY5U DMW2VZ1 MN Adenosine A3 receptor (ADORA3) DMW2VZ1 MT DTT DMW2VZ1 MA Inhibitor DMW2VZ1 RN 2,6,8-trisubstituted 1-deazapurines as adenosine receptor antagonists. J Med Chem. 2007 Feb 22;50(4):828-34. DMW2VZ1 RU https://pubmed.ncbi.nlm.nih.gov/17300165 DMY3C78 DI DMY3C78 DMY3C78 DN 2,6-diphenyl-8-(1-ethylpropyl)-1-deazapurine DMY3C78 MI TTK25J1 DMY3C78 MN Adenosine A1 receptor (ADORA1) DMY3C78 MT DTT DMY3C78 MA Inhibitor DMY3C78 RN 2,6,8-trisubstituted 1-deazapurines as adenosine receptor antagonists. J Med Chem. 2007 Feb 22;50(4):828-34. DMY3C78 RU https://pubmed.ncbi.nlm.nih.gov/17300165 DMY3C78 DI DMY3C78 DMY3C78 DN 2,6-diphenyl-8-(1-ethylpropyl)-1-deazapurine DMY3C78 MI TTM2AOE DMY3C78 MN Adenosine A2a receptor (ADORA2A) DMY3C78 MT DTT DMY3C78 MA Inhibitor DMY3C78 RN 2,6,8-trisubstituted 1-deazapurines as adenosine receptor antagonists. J Med Chem. 2007 Feb 22;50(4):828-34. DMY3C78 RU https://pubmed.ncbi.nlm.nih.gov/17300165 DMY3C78 DI DMY3C78 DMY3C78 DN 2,6-diphenyl-8-(1-ethylpropyl)-1-deazapurine DMY3C78 MI TTNE7KG DMY3C78 MN Adenosine A2b receptor (ADORA2B) DMY3C78 MT DTT DMY3C78 MA Inhibitor DMY3C78 RN 2,6,8-trisubstituted 1-deazapurines as adenosine receptor antagonists. J Med Chem. 2007 Feb 22;50(4):828-34. DMY3C78 RU https://pubmed.ncbi.nlm.nih.gov/17300165 DMY3C78 DI DMY3C78 DMY3C78 DN 2,6-diphenyl-8-(1-ethylpropyl)-1-deazapurine DMY3C78 MI TTJFY5U DMY3C78 MN Adenosine A3 receptor (ADORA3) DMY3C78 MT DTT DMY3C78 MA Inhibitor DMY3C78 RN 2,6,8-trisubstituted 1-deazapurines as adenosine receptor antagonists. J Med Chem. 2007 Feb 22;50(4):828-34. DMY3C78 RU https://pubmed.ncbi.nlm.nih.gov/17300165 DM0C8BW DI DM0C8BW DM0C8BW DN 2,6-diphenyl-8-ethyl-1-deazapurine DM0C8BW MI TTK25J1 DM0C8BW MN Adenosine A1 receptor (ADORA1) DM0C8BW MT DTT DM0C8BW MA Inhibitor DM0C8BW RN 2,6,8-trisubstituted 1-deazapurines as adenosine receptor antagonists. J Med Chem. 2007 Feb 22;50(4):828-34. DM0C8BW RU https://pubmed.ncbi.nlm.nih.gov/17300165 DM0C8BW DI DM0C8BW DM0C8BW DN 2,6-diphenyl-8-ethyl-1-deazapurine DM0C8BW MI TTM2AOE DM0C8BW MN Adenosine A2a receptor (ADORA2A) DM0C8BW MT DTT DM0C8BW MA Inhibitor DM0C8BW RN 2,6,8-trisubstituted 1-deazapurines as adenosine receptor antagonists. J Med Chem. 2007 Feb 22;50(4):828-34. DM0C8BW RU https://pubmed.ncbi.nlm.nih.gov/17300165 DM0C8BW DI DM0C8BW DM0C8BW DN 2,6-diphenyl-8-ethyl-1-deazapurine DM0C8BW MI TTJFY5U DM0C8BW MN Adenosine A3 receptor (ADORA3) DM0C8BW MT DTT DM0C8BW MA Inhibitor DM0C8BW RN 2,6,8-trisubstituted 1-deazapurines as adenosine receptor antagonists. J Med Chem. 2007 Feb 22;50(4):828-34. DM0C8BW RU https://pubmed.ncbi.nlm.nih.gov/17300165 DMI79FV DI DMI79FV DMI79FV DN 2,6-diphenyl-8-methyl-1-deazapurine DMI79FV MI TTK25J1 DMI79FV MN Adenosine A1 receptor (ADORA1) DMI79FV MT DTT DMI79FV MA Inhibitor DMI79FV RN 2,6,8-trisubstituted 1-deazapurines as adenosine receptor antagonists. J Med Chem. 2007 Feb 22;50(4):828-34. DMI79FV RU https://pubmed.ncbi.nlm.nih.gov/17300165 DMI79FV DI DMI79FV DMI79FV DN 2,6-diphenyl-8-methyl-1-deazapurine DMI79FV MI TTM2AOE DMI79FV MN Adenosine A2a receptor (ADORA2A) DMI79FV MT DTT DMI79FV MA Inhibitor DMI79FV RN 2,6,8-trisubstituted 1-deazapurines as adenosine receptor antagonists. J Med Chem. 2007 Feb 22;50(4):828-34. DMI79FV RU https://pubmed.ncbi.nlm.nih.gov/17300165 DMI79FV DI DMI79FV DMI79FV DN 2,6-diphenyl-8-methyl-1-deazapurine DMI79FV MI TTJFY5U DMI79FV MN Adenosine A3 receptor (ADORA3) DMI79FV MT DTT DMI79FV MA Inhibitor DMI79FV RN 2,6,8-trisubstituted 1-deazapurines as adenosine receptor antagonists. J Med Chem. 2007 Feb 22;50(4):828-34. DMI79FV RU https://pubmed.ncbi.nlm.nih.gov/17300165 DM6D1BQ DI DM6D1BQ DM6D1BQ DN 2,6-diphenyl-8-tButyl-1-deazapurine DM6D1BQ MI TTK25J1 DM6D1BQ MN Adenosine A1 receptor (ADORA1) DM6D1BQ MT DTT DM6D1BQ MA Inhibitor DM6D1BQ RN 2,6,8-trisubstituted 1-deazapurines as adenosine receptor antagonists. J Med Chem. 2007 Feb 22;50(4):828-34. DM6D1BQ RU https://pubmed.ncbi.nlm.nih.gov/17300165 DM6D1BQ DI DM6D1BQ DM6D1BQ DN 2,6-diphenyl-8-tButyl-1-deazapurine DM6D1BQ MI TTM2AOE DM6D1BQ MN Adenosine A2a receptor (ADORA2A) DM6D1BQ MT DTT DM6D1BQ MA Inhibitor DM6D1BQ RN 2,6,8-trisubstituted 1-deazapurines as adenosine receptor antagonists. J Med Chem. 2007 Feb 22;50(4):828-34. DM6D1BQ RU https://pubmed.ncbi.nlm.nih.gov/17300165 DM6D1BQ DI DM6D1BQ DM6D1BQ DN 2,6-diphenyl-8-tButyl-1-deazapurine DM6D1BQ MI TTJFY5U DM6D1BQ MN Adenosine A3 receptor (ADORA3) DM6D1BQ MT DTT DM6D1BQ MA Inhibitor DM6D1BQ RN 2,6,8-trisubstituted 1-deazapurines as adenosine receptor antagonists. J Med Chem. 2007 Feb 22;50(4):828-34. DM6D1BQ RU https://pubmed.ncbi.nlm.nih.gov/17300165 DM5SXYI DI DM5SXYI DM5SXYI DN 2,6-diphenyl-9H-purine DM5SXYI MI TTK25J1 DM5SXYI MN Adenosine A1 receptor (ADORA1) DM5SXYI MT DTT DM5SXYI MA Inhibitor DM5SXYI RN 2,6-disubstituted and 2,6,8-trisubstituted purines as adenosine receptor antagonists. J Med Chem. 2006 May 18;49(10):2861-7. DM5SXYI RU https://pubmed.ncbi.nlm.nih.gov/16686529 DM5SXYI DI DM5SXYI DM5SXYI DN 2,6-diphenyl-9H-purine DM5SXYI MI TTM2AOE DM5SXYI MN Adenosine A2a receptor (ADORA2A) DM5SXYI MT DTT DM5SXYI MA Inhibitor DM5SXYI RN 2,6-disubstituted and 2,6,8-trisubstituted purines as adenosine receptor antagonists. J Med Chem. 2006 May 18;49(10):2861-7. DM5SXYI RU https://pubmed.ncbi.nlm.nih.gov/16686529 DM5SXYI DI DM5SXYI DM5SXYI DN 2,6-diphenyl-9H-purine DM5SXYI MI TTJFY5U DM5SXYI MN Adenosine A3 receptor (ADORA3) DM5SXYI MT DTT DM5SXYI MA Inhibitor DM5SXYI RN 2,6-disubstituted and 2,6,8-trisubstituted purines as adenosine receptor antagonists. J Med Chem. 2006 May 18;49(10):2861-7. DM5SXYI RU https://pubmed.ncbi.nlm.nih.gov/16686529 DM3JURW DI DM3JURW DM3JURW DN 2,6-Diphenyl-pyrimidin-4-ylamine DM3JURW MI TTK25J1 DM3JURW MN Adenosine A1 receptor (ADORA1) DM3JURW MT DTT DM3JURW MA Inhibitor DM3JURW RN A new generation of adenosine receptor antagonists: from di- to trisubstituted aminopyrimidines. Bioorg Med Chem. 2008 Mar 15;16(6):2741-52. DM3JURW RU https://pubmed.ncbi.nlm.nih.gov/18258439 DM3JURW DI DM3JURW DM3JURW DN 2,6-Diphenyl-pyrimidin-4-ylamine DM3JURW MI TTM2AOE DM3JURW MN Adenosine A2a receptor (ADORA2A) DM3JURW MT DTT DM3JURW MA Inhibitor DM3JURW RN A new generation of adenosine receptor antagonists: from di- to trisubstituted aminopyrimidines. Bioorg Med Chem. 2008 Mar 15;16(6):2741-52. DM3JURW RU https://pubmed.ncbi.nlm.nih.gov/18258439 DMY8LDT DI DMY8LDT DMY8LDT DN 2,6-di-t-butylphenol DMY8LDT MI TTANPDJ DMY8LDT MN Carbonic anhydrase II (CA-II) DMY8LDT MT DTT DMY8LDT MA Inhibitor DMY8LDT RN Carbonic anhydrase inhibitors. Inhibition of human erythrocyte isozymes I and II with a series of antioxidant phenols. Bioorg Med Chem. 2009 Apr 15;17(8):3207-11. DMY8LDT RU https://pubmed.ncbi.nlm.nih.gov/19231207 DMFO1H2 DI DMFO1H2 DMFO1H2 DN 2,6-di-tert-butyl-4-methoxyphenol DMFO1H2 MI TTANPDJ DMFO1H2 MN Carbonic anhydrase II (CA-II) DMFO1H2 MT DTT DMFO1H2 MA Inhibitor DMFO1H2 RN Carbonic anhydrase inhibitors. Inhibition of human erythrocyte isozymes I and II with a series of antioxidant phenols. Bioorg Med Chem. 2009 Apr 15;17(8):3207-11. DMFO1H2 RU https://pubmed.ncbi.nlm.nih.gov/19231207 DM8F9KO DI DM8F9KO DM8F9KO DN 2,6-dphenyl-8-propyl-1-deazapurine DM8F9KO MI TTK25J1 DM8F9KO MN Adenosine A1 receptor (ADORA1) DM8F9KO MT DTT DM8F9KO MA Inhibitor DM8F9KO RN 2,6,8-trisubstituted 1-deazapurines as adenosine receptor antagonists. J Med Chem. 2007 Feb 22;50(4):828-34. DM8F9KO RU https://pubmed.ncbi.nlm.nih.gov/17300165 DM8F9KO DI DM8F9KO DM8F9KO DN 2,6-dphenyl-8-propyl-1-deazapurine DM8F9KO MI TTM2AOE DM8F9KO MN Adenosine A2a receptor (ADORA2A) DM8F9KO MT DTT DM8F9KO MA Inhibitor DM8F9KO RN 2,6,8-trisubstituted 1-deazapurines as adenosine receptor antagonists. J Med Chem. 2007 Feb 22;50(4):828-34. DM8F9KO RU https://pubmed.ncbi.nlm.nih.gov/17300165 DM8F9KO DI DM8F9KO DM8F9KO DN 2,6-dphenyl-8-propyl-1-deazapurine DM8F9KO MI TTJFY5U DM8F9KO MN Adenosine A3 receptor (ADORA3) DM8F9KO MT DTT DM8F9KO MA Inhibitor DM8F9KO RN 2,6,8-trisubstituted 1-deazapurines as adenosine receptor antagonists. J Med Chem. 2007 Feb 22;50(4):828-34. DM8F9KO RU https://pubmed.ncbi.nlm.nih.gov/17300165 DMT9JHV DI DMT9JHV DMT9JHV DN 2,7-Bis(3-chloropropionamido)anthraquinone DMT9JHV MI TTQY2EJ DMT9JHV MN TERT messenger RNA (TERT mRNA) DMT9JHV MT DTT DMT9JHV MA Inhibitor DMT9JHV RN Synthesis, human telomerase inhibition and anti-proliferative studies of a series of 2,7-bis-substituted amido-anthraquinone derivatives. Bioorg Med Chem. 2008 Jul 15;16(14):6976-86. DMT9JHV RU https://pubmed.ncbi.nlm.nih.gov/18571928 DM8VWQ2 DI DM8VWQ2 DM8VWQ2 DN 2,7-Bis(4-chlorobutyramido)anthraquinone DM8VWQ2 MI TTQY2EJ DM8VWQ2 MN TERT messenger RNA (TERT mRNA) DM8VWQ2 MT DTT DM8VWQ2 MA Inhibitor DM8VWQ2 RN Synthesis, human telomerase inhibition and anti-proliferative studies of a series of 2,7-bis-substituted amido-anthraquinone derivatives. Bioorg Med Chem. 2008 Jul 15;16(14):6976-86. DM8VWQ2 RU https://pubmed.ncbi.nlm.nih.gov/18571928 DM2EPM4 DI DM2EPM4 DM2EPM4 DN 2,7-Bis(acetamido)anthraquinone DM2EPM4 MI TTQY2EJ DM2EPM4 MN TERT messenger RNA (TERT mRNA) DM2EPM4 MT DTT DM2EPM4 MA Inhibitor DM2EPM4 RN Synthesis, human telomerase inhibition and anti-proliferative studies of a series of 2,7-bis-substituted amido-anthraquinone derivatives. Bioorg Med Chem. 2008 Jul 15;16(14):6976-86. DM2EPM4 RU https://pubmed.ncbi.nlm.nih.gov/18571928 DMEQC4X DI DMEQC4X DMEQC4X DN 2,7-Bis(benzoamido)anthraquinone DMEQC4X MI TTQY2EJ DMEQC4X MN TERT messenger RNA (TERT mRNA) DMEQC4X MT DTT DMEQC4X MA Inhibitor DMEQC4X RN Synthesis, human telomerase inhibition and anti-proliferative studies of a series of 2,7-bis-substituted amido-anthraquinone derivatives. Bioorg Med Chem. 2008 Jul 15;16(14):6976-86. DMEQC4X RU https://pubmed.ncbi.nlm.nih.gov/18571928 DM9S8LY DI DM9S8LY DM9S8LY DN 2,7-Bis(butyramido)anthraquinone DM9S8LY MI TTQY2EJ DM9S8LY MN TERT messenger RNA (TERT mRNA) DM9S8LY MT DTT DM9S8LY MA Inhibitor DM9S8LY RN Synthesis, human telomerase inhibition and anti-proliferative studies of a series of 2,7-bis-substituted amido-anthraquinone derivatives. Bioorg Med Chem. 2008 Jul 15;16(14):6976-86. DM9S8LY RU https://pubmed.ncbi.nlm.nih.gov/18571928 DM4MYAR DI DM4MYAR DM4MYAR DN 2,7-Bis(chloroacetamido)anthraquinone DM4MYAR MI TTQY2EJ DM4MYAR MN TERT messenger RNA (TERT mRNA) DM4MYAR MT DTT DM4MYAR MA Inhibitor DM4MYAR RN Synthesis, human telomerase inhibition and anti-proliferative studies of a series of 2,7-bis-substituted amido-anthraquinone derivatives. Bioorg Med Chem. 2008 Jul 15;16(14):6976-86. DM4MYAR RU https://pubmed.ncbi.nlm.nih.gov/18571928 DMTPZ8D DI DMTPZ8D DMTPZ8D DN 2,7-Bis(cyclohexanecarbonamido)anthraquinone DMTPZ8D MI TTQY2EJ DMTPZ8D MN TERT messenger RNA (TERT mRNA) DMTPZ8D MT DTT DMTPZ8D MA Inhibitor DMTPZ8D RN Synthesis, human telomerase inhibition and anti-proliferative studies of a series of 2,7-bis-substituted amido-anthraquinone derivatives. Bioorg Med Chem. 2008 Jul 15;16(14):6976-86. DMTPZ8D RU https://pubmed.ncbi.nlm.nih.gov/18571928 DMP3EZ8 DI DMP3EZ8 DMP3EZ8 DN 2,7-Bis(cyclopentanecarbonamido)anthraquinone DMP3EZ8 MI TTQY2EJ DMP3EZ8 MN TERT messenger RNA (TERT mRNA) DMP3EZ8 MT DTT DMP3EZ8 MA Inhibitor DMP3EZ8 RN Synthesis, human telomerase inhibition and anti-proliferative studies of a series of 2,7-bis-substituted amido-anthraquinone derivatives. Bioorg Med Chem. 2008 Jul 15;16(14):6976-86. DMP3EZ8 RU https://pubmed.ncbi.nlm.nih.gov/18571928 DMY3V2B DI DMY3V2B DMY3V2B DN 2,7-Bis(cyclopropanecarbonamido)anthraquinone DMY3V2B MI TTQY2EJ DMY3V2B MN TERT messenger RNA (TERT mRNA) DMY3V2B MT DTT DMY3V2B MA Inhibitor DMY3V2B RN Synthesis, human telomerase inhibition and anti-proliferative studies of a series of 2,7-bis-substituted amido-anthraquinone derivatives. Bioorg Med Chem. 2008 Jul 15;16(14):6976-86. DMY3V2B RU https://pubmed.ncbi.nlm.nih.gov/18571928 DMEVIBT DI DMEVIBT DMEVIBT DN 2,7-Bis(phenylacetamido)anthraquinone DMEVIBT MI TTQY2EJ DMEVIBT MN TERT messenger RNA (TERT mRNA) DMEVIBT MT DTT DMEVIBT MA Inhibitor DMEVIBT RN Synthesis, human telomerase inhibition and anti-proliferative studies of a series of 2,7-bis-substituted amido-anthraquinone derivatives. Bioorg Med Chem. 2008 Jul 15;16(14):6976-86. DMEVIBT RU https://pubmed.ncbi.nlm.nih.gov/18571928 DMDKXEY DI DMDKXEY DMDKXEY DN 2,7-Bis(phenylpropionamido)anthraquinone DMDKXEY MI TTQY2EJ DMDKXEY MN TERT messenger RNA (TERT mRNA) DMDKXEY MT DTT DMDKXEY MA Inhibitor DMDKXEY RN Synthesis, human telomerase inhibition and anti-proliferative studies of a series of 2,7-bis-substituted amido-anthraquinone derivatives. Bioorg Med Chem. 2008 Jul 15;16(14):6976-86. DMDKXEY RU https://pubmed.ncbi.nlm.nih.gov/18571928 DM2D1EJ DI DM2D1EJ DM2D1EJ DN 2,7-Bis(propionamido)anthraquinone DM2D1EJ MI TTQY2EJ DM2D1EJ MN TERT messenger RNA (TERT mRNA) DM2D1EJ MT DTT DM2D1EJ MA Inhibitor DM2D1EJ RN Synthesis, human telomerase inhibition and anti-proliferative studies of a series of 2,7-bis-substituted amido-anthraquinone derivatives. Bioorg Med Chem. 2008 Jul 15;16(14):6976-86. DM2D1EJ RU https://pubmed.ncbi.nlm.nih.gov/18571928 DM3GTV0 DI DM3GTV0 DM3GTV0 DN 2,7-Bis[2-(butylamino)acetamido]anthraquinone DM3GTV0 MI TTQY2EJ DM3GTV0 MN TERT messenger RNA (TERT mRNA) DM3GTV0 MT DTT DM3GTV0 MA Inhibitor DM3GTV0 RN Synthesis, human telomerase inhibition and anti-proliferative studies of a series of 2,7-bis-substituted amido-anthraquinone derivatives. Bioorg Med Chem. 2008 Jul 15;16(14):6976-86. DM3GTV0 RU https://pubmed.ncbi.nlm.nih.gov/18571928 DMKDSGE DI DMKDSGE DMKDSGE DN 2,7-Bis[2-(diethylamino)acetamido]anthraquinone DMKDSGE MI TTQY2EJ DMKDSGE MN TERT messenger RNA (TERT mRNA) DMKDSGE MT DTT DMKDSGE MA Inhibitor DMKDSGE RN Synthesis, human telomerase inhibition and anti-proliferative studies of a series of 2,7-bis-substituted amido-anthraquinone derivatives. Bioorg Med Chem. 2008 Jul 15;16(14):6976-86. DMKDSGE RU https://pubmed.ncbi.nlm.nih.gov/18571928 DMNW5PL DI DMNW5PL DMNW5PL DN 2,7-Bis[2-(dimethylamino)acetamido]anthraquinone DMNW5PL MI TTQY2EJ DMNW5PL MN TERT messenger RNA (TERT mRNA) DMNW5PL MT DTT DMNW5PL MA Inhibitor DMNW5PL RN Synthesis, human telomerase inhibition and anti-proliferative studies of a series of 2,7-bis-substituted amido-anthraquinone derivatives. Bioorg Med Chem. 2008 Jul 15;16(14):6976-86. DMNW5PL RU https://pubmed.ncbi.nlm.nih.gov/18571928 DMZ7EAC DI DMZ7EAC DMZ7EAC DN 2,7-Bis[2-(ethylamino)acetamido]anthraquinone DMZ7EAC MI TTQY2EJ DMZ7EAC MN TERT messenger RNA (TERT mRNA) DMZ7EAC MT DTT DMZ7EAC MA Inhibitor DMZ7EAC RN Synthesis, human telomerase inhibition and anti-proliferative studies of a series of 2,7-bis-substituted amido-anthraquinone derivatives. Bioorg Med Chem. 2008 Jul 15;16(14):6976-86. DMZ7EAC RU https://pubmed.ncbi.nlm.nih.gov/18571928 DMM4T1Q DI DMM4T1Q DMM4T1Q DN 2,7-Bis[2-(isobutylamino)acetamido]anthraquinone DMM4T1Q MI TTQY2EJ DMM4T1Q MN TERT messenger RNA (TERT mRNA) DMM4T1Q MT DTT DMM4T1Q MA Inhibitor DMM4T1Q RN Synthesis, human telomerase inhibition and anti-proliferative studies of a series of 2,7-bis-substituted amido-anthraquinone derivatives. Bioorg Med Chem. 2008 Jul 15;16(14):6976-86. DMM4T1Q RU https://pubmed.ncbi.nlm.nih.gov/18571928 DMRQGWX DI DMRQGWX DMRQGWX DN 2,7-Bis[2-(isopropylamino)acetamido]anthraquinone DMRQGWX MI TTQY2EJ DMRQGWX MN TERT messenger RNA (TERT mRNA) DMRQGWX MT DTT DMRQGWX MA Inhibitor DMRQGWX RN Synthesis, human telomerase inhibition and anti-proliferative studies of a series of 2,7-bis-substituted amido-anthraquinone derivatives. Bioorg Med Chem. 2008 Jul 15;16(14):6976-86. DMRQGWX RU https://pubmed.ncbi.nlm.nih.gov/18571928 DMPE8GX DI DMPE8GX DMPE8GX DN 2,7-Bis[2-(piperazino)acetamido]anthraquinone DMPE8GX MI TTQY2EJ DMPE8GX MN TERT messenger RNA (TERT mRNA) DMPE8GX MT DTT DMPE8GX MA Inhibitor DMPE8GX RN Synthesis, human telomerase inhibition and anti-proliferative studies of a series of 2,7-bis-substituted amido-anthraquinone derivatives. Bioorg Med Chem. 2008 Jul 15;16(14):6976-86. DMPE8GX RU https://pubmed.ncbi.nlm.nih.gov/18571928 DMITF0P DI DMITF0P DMITF0P DN 2,7-Bis[2-(piperidino)acetamido]anthraquinone DMITF0P MI TTQY2EJ DMITF0P MN TERT messenger RNA (TERT mRNA) DMITF0P MT DTT DMITF0P MA Inhibitor DMITF0P RN Synthesis, human telomerase inhibition and anti-proliferative studies of a series of 2,7-bis-substituted amido-anthraquinone derivatives. Bioorg Med Chem. 2008 Jul 15;16(14):6976-86. DMITF0P RU https://pubmed.ncbi.nlm.nih.gov/18571928 DMH89TO DI DMH89TO DMH89TO DN 2,7-Bis[2-(propylamino)acetamido]anthraquinone DMH89TO MI TTQY2EJ DMH89TO MN TERT messenger RNA (TERT mRNA) DMH89TO MT DTT DMH89TO MA Inhibitor DMH89TO RN Synthesis, human telomerase inhibition and anti-proliferative studies of a series of 2,7-bis-substituted amido-anthraquinone derivatives. Bioorg Med Chem. 2008 Jul 15;16(14):6976-86. DMH89TO RU https://pubmed.ncbi.nlm.nih.gov/18571928 DMHVKIJ DI DMHVKIJ DMHVKIJ DN 2,7-Bis[2-(pyrrolidino)acetamido]anthraquinone DMHVKIJ MI TTQY2EJ DMHVKIJ MN TERT messenger RNA (TERT mRNA) DMHVKIJ MT DTT DMHVKIJ MA Inhibitor DMHVKIJ RN Synthesis, human telomerase inhibition and anti-proliferative studies of a series of 2,7-bis-substituted amido-anthraquinone derivatives. Bioorg Med Chem. 2008 Jul 15;16(14):6976-86. DMHVKIJ RU https://pubmed.ncbi.nlm.nih.gov/18571928 DM4V63W DI DM4V63W DM4V63W DN 2,7-Bis[3-(butylamino)propionamido]anthraquinone DM4V63W MI TTQY2EJ DM4V63W MN TERT messenger RNA (TERT mRNA) DM4V63W MT DTT DM4V63W MA Inhibitor DM4V63W RN Synthesis, human telomerase inhibition and anti-proliferative studies of a series of 2,7-bis-substituted amido-anthraquinone derivatives. Bioorg Med Chem. 2008 Jul 15;16(14):6976-86. DM4V63W RU https://pubmed.ncbi.nlm.nih.gov/18571928 DMC537F DI DMC537F DMC537F DN 2,7-Bis[3-(ethylamino)propionamido]anthraquinone DMC537F MI TTQY2EJ DMC537F MN TERT messenger RNA (TERT mRNA) DMC537F MT DTT DMC537F MA Inhibitor DMC537F RN Synthesis, human telomerase inhibition and anti-proliferative studies of a series of 2,7-bis-substituted amido-anthraquinone derivatives. Bioorg Med Chem. 2008 Jul 15;16(14):6976-86. DMC537F RU https://pubmed.ncbi.nlm.nih.gov/18571928 DMOZEKQ DI DMOZEKQ DMOZEKQ DN 2,7-Bis[3-(piperazino)propionamido]anthraquinone DMOZEKQ MI TTQY2EJ DMOZEKQ MN TERT messenger RNA (TERT mRNA) DMOZEKQ MT DTT DMOZEKQ MA Inhibitor DMOZEKQ RN Synthesis, human telomerase inhibition and anti-proliferative studies of a series of 2,7-bis-substituted amido-anthraquinone derivatives. Bioorg Med Chem. 2008 Jul 15;16(14):6976-86. DMOZEKQ RU https://pubmed.ncbi.nlm.nih.gov/18571928 DMET693 DI DMET693 DMET693 DN 2,7-Bis[3-(piperidino)propionamido]anthraquinone DMET693 MI TTQY2EJ DMET693 MN TERT messenger RNA (TERT mRNA) DMET693 MT DTT DMET693 MA Inhibitor DMET693 RN Synthesis, human telomerase inhibition and anti-proliferative studies of a series of 2,7-bis-substituted amido-anthraquinone derivatives. Bioorg Med Chem. 2008 Jul 15;16(14):6976-86. DMET693 RU https://pubmed.ncbi.nlm.nih.gov/18571928 DM6I90F DI DM6I90F DM6I90F DN 2,7-Bis[3-(propylamino)propionamido]anthraquinone DM6I90F MI TTQY2EJ DM6I90F MN TERT messenger RNA (TERT mRNA) DM6I90F MT DTT DM6I90F MA Inhibitor DM6I90F RN Synthesis, human telomerase inhibition and anti-proliferative studies of a series of 2,7-bis-substituted amido-anthraquinone derivatives. Bioorg Med Chem. 2008 Jul 15;16(14):6976-86. DM6I90F RU https://pubmed.ncbi.nlm.nih.gov/18571928 DMD6ZV5 DI DMD6ZV5 DMD6ZV5 DN 2,7-Bis[3-(pyrrolidino)propionamido]anthraquinone DMD6ZV5 MI TTQY2EJ DMD6ZV5 MN TERT messenger RNA (TERT mRNA) DMD6ZV5 MT DTT DMD6ZV5 MA Inhibitor DMD6ZV5 RN Synthesis, human telomerase inhibition and anti-proliferative studies of a series of 2,7-bis-substituted amido-anthraquinone derivatives. Bioorg Med Chem. 2008 Jul 15;16(14):6976-86. DMD6ZV5 RU https://pubmed.ncbi.nlm.nih.gov/18571928 DME0TZU DI DME0TZU DME0TZU DN 2,7-diaminoanthraquinone DME0TZU MI TTQY2EJ DME0TZU MN TERT messenger RNA (TERT mRNA) DME0TZU MT DTT DME0TZU MA Inhibitor DME0TZU RN Synthesis, human telomerase inhibition and anti-proliferative studies of a series of 2,7-bis-substituted amido-anthraquinone derivatives. Bioorg Med Chem. 2008 Jul 15;16(14):6976-86. DME0TZU RU https://pubmed.ncbi.nlm.nih.gov/18571928 DMN56VM DI DMN56VM DMN56VM DN 2,7-Dinitroantraquinone DMN56VM MI TTQY2EJ DMN56VM MN TERT messenger RNA (TERT mRNA) DMN56VM MT DTT DMN56VM MA Inhibitor DMN56VM RN Synthesis, human telomerase inhibition and anti-proliferative studies of a series of 2,7-bis-substituted amido-anthraquinone derivatives. Bioorg Med Chem. 2008 Jul 15;16(14):6976-86. DMN56VM RU https://pubmed.ncbi.nlm.nih.gov/18571928 DMAKZ43 DI DMAKZ43 DMAKZ43 DN 2,8-Dimethyl-1-oxa-8-aza-spiro[4.5]decan-3-one DMAKZ43 MI TTZ9SOR DMAKZ43 MN Muscarinic acetylcholine receptor M1 (CHRM1) DMAKZ43 MT DTT DMAKZ43 MA Inhibitor DMAKZ43 RN Synthesis and modeling studies of a potent conformationally rigid muscarinic agonist: 1-azabicyclo[2.2.1]heptanespirofuranone. J Med Chem. 1998 Oct 22;41(22):4181-5. DMAKZ43 RU https://pubmed.ncbi.nlm.nih.gov/9784090 DMAKZ43 DI DMAKZ43 DMAKZ43 DN 2,8-Dimethyl-1-oxa-8-aza-spiro[4.5]decan-3-one DMAKZ43 MI TTYEG6Q DMAKZ43 MN Muscarinic acetylcholine receptor M2 (CHRM2) DMAKZ43 MT DTT DMAKZ43 MA Inhibitor DMAKZ43 RN Synthesis and modeling studies of a potent conformationally rigid muscarinic agonist: 1-azabicyclo[2.2.1]heptanespirofuranone. J Med Chem. 1998 Oct 22;41(22):4181-5. DMAKZ43 RU https://pubmed.ncbi.nlm.nih.gov/9784090 DMAKZ43 DI DMAKZ43 DMAKZ43 DN 2,8-Dimethyl-1-oxa-8-aza-spiro[4.5]decan-3-one DMAKZ43 MI TTQ13Z5 DMAKZ43 MN Muscarinic acetylcholine receptor M3 (CHRM3) DMAKZ43 MT DTT DMAKZ43 MA Inhibitor DMAKZ43 RN Synthesis and modeling studies of a potent conformationally rigid muscarinic agonist: 1-azabicyclo[2.2.1]heptanespirofuranone. J Med Chem. 1998 Oct 22;41(22):4181-5. DMAKZ43 RU https://pubmed.ncbi.nlm.nih.gov/9784090 DMAKZ43 DI DMAKZ43 DMAKZ43 DN 2,8-Dimethyl-1-oxa-8-aza-spiro[4.5]decan-3-one DMAKZ43 MI TTQ3JTF DMAKZ43 MN Muscarinic acetylcholine receptor M4 (CHRM4) DMAKZ43 MT DTT DMAKZ43 MA Inhibitor DMAKZ43 RN Synthesis and modeling studies of a potent conformationally rigid muscarinic agonist: 1-azabicyclo[2.2.1]heptanespirofuranone. J Med Chem. 1998 Oct 22;41(22):4181-5. DMAKZ43 RU https://pubmed.ncbi.nlm.nih.gov/9784090 DMAKZ43 DI DMAKZ43 DMAKZ43 DN 2,8-Dimethyl-1-oxa-8-aza-spiro[4.5]decan-3-one DMAKZ43 MI TTH18TF DMAKZ43 MN Muscarinic acetylcholine receptor M5 (CHRM5) DMAKZ43 MT DTT DMAKZ43 MA Inhibitor DMAKZ43 RN Synthesis and modeling studies of a potent conformationally rigid muscarinic agonist: 1-azabicyclo[2.2.1]heptanespirofuranone. J Med Chem. 1998 Oct 22;41(22):4181-5. DMAKZ43 RU https://pubmed.ncbi.nlm.nih.gov/9784090 DMU2EFH DI DMU2EFH DMU2EFH DN 2,8-Dimethyl-3H-quinazolin-4-one DMU2EFH MI TTVDSZ0 DMU2EFH MN Poly [ADP-ribose] polymerase 1 (PARP1) DMU2EFH MT DTT DMU2EFH MA Inhibitor DMU2EFH RN Resistance-modifying agents. 5. Synthesis and biological properties of quinazolinone inhibitors of the DNA repair enzyme poly(ADP-ribose) polymeras... J Med Chem. 1998 Dec 17;41(26):5247-56. DMU2EFH RU https://pubmed.ncbi.nlm.nih.gov/9857092 DMVSTG7 DI DMVSTG7 DMVSTG7 DN 2-[(2,2-diphenylacetyl)amino]benzoic acid DMVSTG7 MI TT5ZWB6 DMVSTG7 MN Dihydrodiol dehydrogenase type I (AKR1C3) DMVSTG7 MT DTT DMVSTG7 MA Inhibitor DMVSTG7 RN Nonsteroidal anti-inflammatory drugs and their analogues as inhibitors of aldo-keto reductase AKR1C3: new lead compounds for the development of ant... Bioorg Med Chem Lett. 2005 Dec 1;15(23):5170-5. DMVSTG7 RU https://pubmed.ncbi.nlm.nih.gov/16183274 DMR4LJY DI DMR4LJY DMR4LJY DN 2-[(2',3',4'-TRIFLUOROBIPHENYL-2-YL)OXY]ETHANOL DMR4LJY MI TTUMQVO DMR4LJY MN Cathepsin S (CTSS) DMR4LJY MT DTT DMR4LJY MA Inhibitor DMR4LJY RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DMR4LJY RU https://pubmed.ncbi.nlm.nih.gov/10592235 DMXA1LK DI DMXA1LK DMXA1LK DN 2-[(2-methoxy-5-methylphenoxy)methyl]pyridine DMXA1LK MI TTQO71U DMXA1LK MN Hemoglobin (HB) DMXA1LK MT DTT DMXA1LK MA Inhibitor DMXA1LK RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DMXA1LK RU https://pubmed.ncbi.nlm.nih.gov/10592235 DM75WN4 DI DM75WN4 DM75WN4 DN 2-[(2-methyl-4-thiazolyl)ethynyl]pyrazine DM75WN4 MI TTHS256 DM75WN4 MN Metabotropic glutamate receptor 5 (mGluR5) DM75WN4 MT DTT DM75WN4 MA Inhibitor DM75WN4 RN Synthesis and structure-activity relationships of 3-[(2-methyl-1,3-thiazol-4-yl)ethynyl]pyridine analogues as potent, noncompetitive metabotropic g... J Med Chem. 2006 Feb 9;49(3):1080-100. DM75WN4 RU https://pubmed.ncbi.nlm.nih.gov/16451073 DMKC1GI DI DMKC1GI DMKC1GI DN 2-[(4-acetylphenyl)ethynyl]-N6-methoxyadenosine DMKC1GI MI TTK25J1 DMKC1GI MN Adenosine A1 receptor (ADORA1) DMKC1GI MT DTT DMKC1GI MA Inhibitor DMKC1GI RN N6-methoxy-2-alkynyladenosine derivatives as highly potent and selective ligands at the human A3 adenosine receptor. J Med Chem. 2007 Mar 22;50(6):1222-30. DMKC1GI RU https://pubmed.ncbi.nlm.nih.gov/17309246 DMKC1GI DI DMKC1GI DMKC1GI DN 2-[(4-acetylphenyl)ethynyl]-N6-methoxyadenosine DMKC1GI MI TTM2AOE DMKC1GI MN Adenosine A2a receptor (ADORA2A) DMKC1GI MT DTT DMKC1GI MA Inhibitor DMKC1GI RN N6-methoxy-2-alkynyladenosine derivatives as highly potent and selective ligands at the human A3 adenosine receptor. J Med Chem. 2007 Mar 22;50(6):1222-30. DMKC1GI RU https://pubmed.ncbi.nlm.nih.gov/17309246 DMKC1GI DI DMKC1GI DMKC1GI DN 2-[(4-acetylphenyl)ethynyl]-N6-methoxyadenosine DMKC1GI MI TTJFY5U DMKC1GI MN Adenosine A3 receptor (ADORA3) DMKC1GI MT DTT DMKC1GI MA Inhibitor DMKC1GI RN N6-methoxy-2-alkynyladenosine derivatives as highly potent and selective ligands at the human A3 adenosine receptor. J Med Chem. 2007 Mar 22;50(6):1222-30. DMKC1GI RU https://pubmed.ncbi.nlm.nih.gov/17309246 DMTNQZU DI DMTNQZU DMTNQZU DN 2-[(4-fluorophenyl)ethynyl]-N6-methoxyadenosine DMTNQZU MI TTK25J1 DMTNQZU MN Adenosine A1 receptor (ADORA1) DMTNQZU MT DTT DMTNQZU MA Inhibitor DMTNQZU RN N6-methoxy-2-alkynyladenosine derivatives as highly potent and selective ligands at the human A3 adenosine receptor. J Med Chem. 2007 Mar 22;50(6):1222-30. DMTNQZU RU https://pubmed.ncbi.nlm.nih.gov/17309246 DMTNQZU DI DMTNQZU DMTNQZU DN 2-[(4-fluorophenyl)ethynyl]-N6-methoxyadenosine DMTNQZU MI TTM2AOE DMTNQZU MN Adenosine A2a receptor (ADORA2A) DMTNQZU MT DTT DMTNQZU MA Inhibitor DMTNQZU RN N6-methoxy-2-alkynyladenosine derivatives as highly potent and selective ligands at the human A3 adenosine receptor. J Med Chem. 2007 Mar 22;50(6):1222-30. DMTNQZU RU https://pubmed.ncbi.nlm.nih.gov/17309246 DMTNQZU DI DMTNQZU DMTNQZU DN 2-[(4-fluorophenyl)ethynyl]-N6-methoxyadenosine DMTNQZU MI TTJFY5U DMTNQZU MN Adenosine A3 receptor (ADORA3) DMTNQZU MT DTT DMTNQZU MA Inhibitor DMTNQZU RN N6-methoxy-2-alkynyladenosine derivatives as highly potent and selective ligands at the human A3 adenosine receptor. J Med Chem. 2007 Mar 22;50(6):1222-30. DMTNQZU RU https://pubmed.ncbi.nlm.nih.gov/17309246 DMDT7SK DI DMDT7SK DMDT7SK DN 2-[(biphenyl-4-carbonyl)-amino]-benzoic acid DMDT7SK MI TT3PQ2Y DMDT7SK MN Plasmodium Dihydroorotate dehydrogenase (Malaria DHOdehase) DMDT7SK MT DTT DMDT7SK MA Inhibitor DMDT7SK RN The first de novo designed inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase. Bioorg Med Chem Lett. 2006 Jan 1;16(1):88-92. DMDT7SK RU https://pubmed.ncbi.nlm.nih.gov/16236496 DMVSI6R DI DMVSI6R DMVSI6R DN 2-[(Dioxidophosphino)Oxy]Benzoate DMVSI6R MI TTLP6GN DMVSI6R MN Bacterial DD-carboxypeptidase (Bact vanYB) DMVSI6R MT DTT DMVSI6R MA Inhibitor DMVSI6R RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMVSI6R RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMSW89U DI DMSW89U DMSW89U DN 2-[1-(2-Chloro-phenyl)-1H-pyrrol-2-yl]-ethylamine DMSW89U MI TTO9X1H DMSW89U MN 5-HT 7 receptor (HTR7) DMSW89U MT DTT DMSW89U MA Inhibitor DMSW89U RN Phenylpyrroles, a new chemolibrary virtual screening class of 5-HT7 receptor ligands. Bioorg Med Chem Lett. 2005 Aug 15;15(16):3753-7. DMSW89U RU https://pubmed.ncbi.nlm.nih.gov/16002287 DMUZDSC DI DMUZDSC DMUZDSC DN 2-[1-(4-CHLORO-PHENYL)-ETHYL]-4,6-DINITRO-PHENOL DMUZDSC MI TTHDSE2 DMUZDSC MN Bacterial Fumarate reductase flavoprotein (Bact frdA) DMUZDSC MT DTT DMUZDSC MA Inhibitor DMUZDSC RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DMUZDSC RU https://pubmed.ncbi.nlm.nih.gov/10592235 DMEA2SR DI DMEA2SR DMEA2SR DN 2-[1,4]Diazepan-1-yl-6-nitro-quinoline DMEA2SR MI TT3ROYC DMEA2SR MN Serotonin transporter (SERT) DMEA2SR MT DTT DMEA2SR MA Inhibitor DMEA2SR RN Syntheses and binding affinities of 6-nitroquipazine analogues for serotonin transporter. Part 1. Bioorg Med Chem Lett. 2000 Jul 17;10(14):1559-62. DMEA2SR RU https://pubmed.ncbi.nlm.nih.gov/10915050 DMC8IEM DI DMC8IEM DMC8IEM DN 2-[1,4]Oxazepan-4-yl-benzo[h]chromen-4-one DMC8IEM MI TTK3PY9 DMC8IEM MN DNA-dependent protein kinase catalytic (PRKDC) DMC8IEM MT DTT DMC8IEM MA Inhibitor DMC8IEM RN Selective benzopyranone and pyrimido[2,1-a]isoquinolin-4-one inhibitors of DNA-dependent protein kinase: synthesis, structure-activity studies, and... J Med Chem. 2005 Jan 27;48(2):569-85. DMC8IEM RU https://pubmed.ncbi.nlm.nih.gov/15658870 DMFJOHG DI DMFJOHG DMFJOHG DN 2-[125I]melatonin DMFJOHG MI TT0WAIE DMFJOHG MN Melatonin receptor type 1A (MTNR1A) DMFJOHG MT DTT DMFJOHG MA Agonist DMFJOHG RN Melatonin receptor antagonists that differentiate between the human Mel1a and Mel1b recombinant subtypes are used to assess the pharmacological profile of the rabbit retina ML1 presynaptic heteroreceptor. Naunyn Schmiedebergs Arch Pharmacol. 1997 Mar;355(3):365-75. DMFJOHG RU https://pubmed.ncbi.nlm.nih.gov/9089668 DMKEZ5G DI DMKEZ5G DMKEZ5G DN 2-[2-(1H-Imidazol-4-yl)-cyclopropyl]-ethylamine DMKEZ5G MI TT9JNIC DMKEZ5G MN Histamine H3 receptor (H3R) DMKEZ5G MT DTT DMKEZ5G MA Inhibitor DMKEZ5G RN Cyclopropane-based conformational restriction of histamine. (1S,2S)-2-(2-aminoethyl)-1-(1H-imidazol-4-yl)cyclopropane, a highly selective agonist f... J Med Chem. 2003 May 8;46(10):1980-8. DMKEZ5G RU https://pubmed.ncbi.nlm.nih.gov/12723960 DMX1TIU DI DMX1TIU DMX1TIU DN 2-[2-(3,5-Dimethoxy-phenyl)-vinyl]-thiophene DMX1TIU MI TTI84H7 DMX1TIU MN Cytochrome P450 1B1 (CYP1B1) DMX1TIU MT DTT DMX1TIU MA Inhibitor DMX1TIU RN Design, synthesis, and discovery of novel trans-stilbene analogues as potent and selective human cytochrome P450 1B1 inhibitors. J Med Chem. 2002 Jan 3;45(1):160-4. DMX1TIU RU https://pubmed.ncbi.nlm.nih.gov/11754588 DMDT9KG DI DMDT9KG DMDT9KG DN 2-[3-(1-Hydroxy-propyl)-phenyl]-propionic acid DMDT9KG MI TTMWT8Z DMDT9KG MN C-X-C chemokine receptor type 1 (CXCR1) DMDT9KG MT DTT DMDT9KG MA Inhibitor DMDT9KG RN 2-Arylpropionic CXC chemokine receptor 1 (CXCR1) ligands as novel noncompetitive CXCL8 inhibitors. J Med Chem. 2005 Jun 30;48(13):4312-31. DMDT9KG RU https://pubmed.ncbi.nlm.nih.gov/15974585 DMDT9KG DI DMDT9KG DMDT9KG DN 2-[3-(1-Hydroxy-propyl)-phenyl]-propionic acid DMDT9KG MI TT30C9G DMDT9KG MN C-X-C chemokine receptor type 2 (CXCR2) DMDT9KG MT DTT DMDT9KG MA Inhibitor DMDT9KG RN 2-Arylpropionic CXC chemokine receptor 1 (CXCR1) ligands as novel noncompetitive CXCL8 inhibitors. J Med Chem. 2005 Jun 30;48(13):4312-31. DMDT9KG RU https://pubmed.ncbi.nlm.nih.gov/15974585 DMWIUR0 DI DMWIUR0 DMWIUR0 DN 2-[3-(1-Phenyl-ethyl)-phenyl]-propionic acid DMWIUR0 MI TTMWT8Z DMWIUR0 MN C-X-C chemokine receptor type 1 (CXCR1) DMWIUR0 MT DTT DMWIUR0 MA Inhibitor DMWIUR0 RN 2-Arylpropionic CXC chemokine receptor 1 (CXCR1) ligands as novel noncompetitive CXCL8 inhibitors. J Med Chem. 2005 Jun 30;48(13):4312-31. DMWIUR0 RU https://pubmed.ncbi.nlm.nih.gov/15974585 DMWIUR0 DI DMWIUR0 DMWIUR0 DN 2-[3-(1-Phenyl-ethyl)-phenyl]-propionic acid DMWIUR0 MI TT30C9G DMWIUR0 MN C-X-C chemokine receptor type 2 (CXCR2) DMWIUR0 MT DTT DMWIUR0 MA Inhibitor DMWIUR0 RN 2-Arylpropionic CXC chemokine receptor 1 (CXCR1) ligands as novel noncompetitive CXCL8 inhibitors. J Med Chem. 2005 Jun 30;48(13):4312-31. DMWIUR0 RU https://pubmed.ncbi.nlm.nih.gov/15974585 DMKSDT4 DI DMKSDT4 DMKSDT4 DN 2-[3-(2-Methyl-butyl)-phenyl]-propionic acid DMKSDT4 MI TTMWT8Z DMKSDT4 MN C-X-C chemokine receptor type 1 (CXCR1) DMKSDT4 MT DTT DMKSDT4 MA Inhibitor DMKSDT4 RN 2-Arylpropionic CXC chemokine receptor 1 (CXCR1) ligands as novel noncompetitive CXCL8 inhibitors. J Med Chem. 2005 Jun 30;48(13):4312-31. DMKSDT4 RU https://pubmed.ncbi.nlm.nih.gov/15974585 DMKSDT4 DI DMKSDT4 DMKSDT4 DN 2-[3-(2-Methyl-butyl)-phenyl]-propionic acid DMKSDT4 MI TT30C9G DMKSDT4 MN C-X-C chemokine receptor type 2 (CXCR2) DMKSDT4 MT DTT DMKSDT4 MA Inhibitor DMKSDT4 RN 2-Arylpropionic CXC chemokine receptor 1 (CXCR1) ligands as novel noncompetitive CXCL8 inhibitors. J Med Chem. 2005 Jun 30;48(13):4312-31. DMKSDT4 RU https://pubmed.ncbi.nlm.nih.gov/15974585 DM8A3NI DI DM8A3NI DM8A3NI DN 2-[3-(4-Imidazol-1-yl-phenoxy)-propyl]-pyridine DM8A3NI MI TTXV4FI DM8A3NI MN Albendazole monooxygenase (CYP3A4) DM8A3NI MT DTT DM8A3NI MA Inhibitor DM8A3NI RN Imidazole derivatives as new potent and selective 20-HETE synthase inhibitors. Bioorg Med Chem Lett. 2004 Jan 19;14(2):333-6. DM8A3NI RU https://pubmed.ncbi.nlm.nih.gov/14698153 DM8A3NI DI DM8A3NI DM8A3NI DN 2-[3-(4-Imidazol-1-yl-phenoxy)-propyl]-pyridine DM8A3NI MI TTVG215 DM8A3NI MN Debrisoquine 4-hydroxylase (CYP2D6) DM8A3NI MT DTT DM8A3NI MA Inhibitor DM8A3NI RN Imidazole derivatives as new potent and selective 20-HETE synthase inhibitors. Bioorg Med Chem Lett. 2004 Jan 19;14(2):333-6. DM8A3NI RU https://pubmed.ncbi.nlm.nih.gov/14698153 DM5ETL9 DI DM5ETL9 DM5ETL9 DN 2-[3-(Pyridin-4-yloxy)-benzoylamino]-benzoic acid DM5ETL9 MI TTRVTMX DM5ETL9 MN Bacterial Beta-ketoacyl-ACP synthase III (Bact fabH) DM5ETL9 MT DTT DM5ETL9 MA Inhibitor DM5ETL9 RN Structure-based design, synthesis, and study of potent inhibitors of beta-ketoacyl-acyl carrier protein synthase III as potential antimicrobial age... J Med Chem. 2005 Mar 10;48(5):1596-609. DM5ETL9 RU https://pubmed.ncbi.nlm.nih.gov/15743201 DMUH526 DI DMUH526 DMUH526 DN 2-[4-(1-Ethyl-propyl)-piperazin-1-yl]-quinoline DMUH526 MI TT9JNIC DMUH526 MN Histamine H3 receptor (H3R) DMUH526 MT DTT DMUH526 MA Inhibitor DMUH526 RN 2-(4-alkylpiperazin-1-yl)quinolines as a new class of imidazole-free histamine H3 receptor antagonists. J Med Chem. 2005 Jan 13;48(1):306-11. DMUH526 RU https://pubmed.ncbi.nlm.nih.gov/15634025 DMUHECR DI DMUHECR DMUHECR DN 2-[4-(1H-Indol-5-yl)-phenyl]-propionic acid DMUHECR MI TT8NGED DMUHECR MN Prostaglandin G/H synthase 1 (COX-1) DMUHECR MT DTT DMUHECR MA Inhibitor DMUHECR RN Structure-based design of COX-2 selectivity into flurbiprofen. Bioorg Med Chem Lett. 1999 Feb 8;9(3):307-12. DMUHECR RU https://pubmed.ncbi.nlm.nih.gov/10091674 DMWXI06 DI DMWXI06 DMWXI06 DN 2-[4-(2,4-Dichlorophenoxy)Phenoxy]Propanoic Acid DMWXI06 MI TTY84UG DMWXI06 MN Acetyl-CoA carboxylase 2 (ACACB) DMWXI06 MT DTT DMWXI06 MA Inhibitor DMWXI06 RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DMWXI06 RU https://pubmed.ncbi.nlm.nih.gov/10592235 DMDMK5V DI DMDMK5V DMDMK5V DN 2-[4-(2-Azepan-1-ylethoxy)phenoxy]benzooxazole DMDMK5V MI TTXZEAJ DMDMK5V MN Leukotriene A-4 hydrolase (LTA4H) DMDMK5V MT DTT DMDMK5V MA Inhibitor DMDMK5V RN Identification of a potent, selective, and orally active leukotriene a4 hydrolase inhibitor with anti-inflammatory activity. J Med Chem. 2008 Jul 24;51(14):4150-69. DMDMK5V RU https://pubmed.ncbi.nlm.nih.gov/18588282 DM923WK DI DM923WK DM923WK DN 2-[4-(2-Azepan-1-ylethoxy)phenoxy]benzothiazole DM923WK MI TTXZEAJ DM923WK MN Leukotriene A-4 hydrolase (LTA4H) DM923WK MT DTT DM923WK MA Inhibitor DM923WK RN Identification of a potent, selective, and orally active leukotriene a4 hydrolase inhibitor with anti-inflammatory activity. J Med Chem. 2008 Jul 24;51(14):4150-69. DM923WK RU https://pubmed.ncbi.nlm.nih.gov/18588282 DMECQB4 DI DMECQB4 DMECQB4 DN 2-[4-(2-Morpholin-4-ylethoxy)phenoxy]benzooxazole DMECQB4 MI TTXZEAJ DMECQB4 MN Leukotriene A-4 hydrolase (LTA4H) DMECQB4 MT DTT DMECQB4 MA Inhibitor DMECQB4 RN Identification of a potent, selective, and orally active leukotriene a4 hydrolase inhibitor with anti-inflammatory activity. J Med Chem. 2008 Jul 24;51(14):4150-69. DMECQB4 RU https://pubmed.ncbi.nlm.nih.gov/18588282 DMMYJ3R DI DMMYJ3R DMMYJ3R DN 2-[4-(2-Piperidin-1-ylethyl)phenoxy]benzothiazole DMMYJ3R MI TTXZEAJ DMMYJ3R MN Leukotriene A-4 hydrolase (LTA4H) DMMYJ3R MT DTT DMMYJ3R MA Inhibitor DMMYJ3R RN Identification of a potent, selective, and orally active leukotriene a4 hydrolase inhibitor with anti-inflammatory activity. J Med Chem. 2008 Jul 24;51(14):4150-69. DMMYJ3R RU https://pubmed.ncbi.nlm.nih.gov/18588282 DMMYJ3R DI DMMYJ3R DMMYJ3R DN 2-[4-(2-Piperidin-1-ylethyl)phenoxy]benzothiazole DMMYJ3R MI TTQ6VDM DMMYJ3R MN Voltage-gated potassium channel Kv11.1 (KCNH2) DMMYJ3R MT DTT DMMYJ3R MA Inhibitor DMMYJ3R RN Identification of a potent, selective, and orally active leukotriene a4 hydrolase inhibitor with anti-inflammatory activity. J Med Chem. 2008 Jul 24;51(14):4150-69. DMMYJ3R RU https://pubmed.ncbi.nlm.nih.gov/18588282 DM6R1XH DI DM6R1XH DM6R1XH DN 2-[4-(2-Thienyl)phenyl]-4-methylmorpholin-2-ol DM6R1XH MI TTFQEO5 DM6R1XH MN Squalene synthetase (FDFT1) DM6R1XH MT DTT DM6R1XH MA Inhibitor DM6R1XH RN Lipid-lowering (hetero)aromatic tetrahydro-1,4-oxazine derivatives with antioxidant and squalene synthase inhibitory activity. J Med Chem. 2008 Sep 25;51(18):5861-5. DM6R1XH RU https://pubmed.ncbi.nlm.nih.gov/18754614 DMZFKDW DI DMZFKDW DMZFKDW DN 2-[7-(Benzyloxy)-2-oxo-2H-chromen-4-yl]acetamide DMZFKDW MI TT3WG5C DMZFKDW MN Monoamine oxidase type A (MAO-A) DMZFKDW MT DTT DMZFKDW MA Inhibitor DMZFKDW RN Discovery of a novel class of potent coumarin monoamine oxidase B inhibitors: development and biopharmacological profiling of 7-[(3-chlorobenzyl)ox... J Med Chem. 2009 Nov 12;52(21):6685-706. DMZFKDW RU https://pubmed.ncbi.nlm.nih.gov/19810674 DMZFKDW DI DMZFKDW DMZFKDW DN 2-[7-(Benzyloxy)-2-oxo-2H-chromen-4-yl]acetamide DMZFKDW MI TTGP7BY DMZFKDW MN Monoamine oxidase type B (MAO-B) DMZFKDW MT DTT DMZFKDW MA Inhibitor DMZFKDW RN Discovery of a novel class of potent coumarin monoamine oxidase B inhibitors: development and biopharmacological profiling of 7-[(3-chlorobenzyl)ox... J Med Chem. 2009 Nov 12;52(21):6685-706. DMZFKDW RU https://pubmed.ncbi.nlm.nih.gov/19810674 DM1PSRQ DI DM1PSRQ DM1PSRQ DN 2-{[2-(2-phenylethyl)phenoxy]methyl}pyridine DM1PSRQ MI TTSQIFT DM1PSRQ MN 5-HT 1A receptor (HTR1A) DM1PSRQ MT DTT DM1PSRQ MA Inhibitor DM1PSRQ RN Arylmethyloxyphenyl derivatives: small molecules displaying P-glycoprotein inhibition. J Med Chem. 2006 Nov 2;49(22):6607-13. DM1PSRQ RU https://pubmed.ncbi.nlm.nih.gov/17064079 DM1PSRQ DI DM1PSRQ DM1PSRQ DN 2-{[2-(2-phenylethyl)phenoxy]methyl}pyridine DM1PSRQ MI TTEX248 DM1PSRQ MN Dopamine D2 receptor (D2R) DM1PSRQ MT DTT DM1PSRQ MA Inhibitor DM1PSRQ RN Arylmethyloxyphenyl derivatives: small molecules displaying P-glycoprotein inhibition. J Med Chem. 2006 Nov 2;49(22):6607-13. DM1PSRQ RU https://pubmed.ncbi.nlm.nih.gov/17064079 DM9TCWA DI DM9TCWA DM9TCWA DN 2-{[R-(-)-Apomorphine-2'-oxy]ethoxy}-ethanol DM9TCWA MI TTZFYLI DM9TCWA MN Dopamine D1 receptor (D1R) DM9TCWA MT DTT DM9TCWA MA Inhibitor DM9TCWA RN Synthesis and neuropharmacological characterization of 2-O-substituted apomorphines. Bioorg Med Chem. 2008 Apr 15;16(8):4563-8. DM9TCWA RU https://pubmed.ncbi.nlm.nih.gov/18313931 DM9TCWA DI DM9TCWA DM9TCWA DN 2-{[R-(-)-Apomorphine-2'-oxy]ethoxy}-ethanol DM9TCWA MI TTEX248 DM9TCWA MN Dopamine D2 receptor (D2R) DM9TCWA MT DTT DM9TCWA MA Inhibitor DM9TCWA RN Synthesis and neuropharmacological characterization of 2-O-substituted apomorphines. Bioorg Med Chem. 2008 Apr 15;16(8):4563-8. DM9TCWA RU https://pubmed.ncbi.nlm.nih.gov/18313931 DM5BAJ9 DI DM5BAJ9 DM5BAJ9 DN 20-HETE DM5BAJ9 MI TTRBT3W DM5BAJ9 MN Short transient receptor potential channel 6 (TRPC6) DM5BAJ9 MT DTT DM5BAJ9 MA Activator DM5BAJ9 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 491). DM5BAJ9 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=491 DM84GAQ DI DM84GAQ DM84GAQ DN 20-hydroxy-LTB4 DM84GAQ MI TTVJX54 DM84GAQ MN Leukotriene B4 receptor 2 (LTB4R2) DM84GAQ MT DTT DM84GAQ MA Agonist DM84GAQ RN A G-protein-coupled receptor for leukotriene B4 that mediates chemotaxis. Nature. 1997 Jun 5;387(6633):620-4. DM84GAQ RU https://pubmed.ncbi.nlm.nih.gov/9177352 DMHJM0F DI DMHJM0F DMHJM0F DN 227Th-rituximab DMHJM0F MI TTUE541 DMHJM0F MN Leukocyte surface antigen Leu-16 (CD20) DMHJM0F MT DTT DMHJM0F RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2628). DMHJM0F RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2628 DME8273 DI DME8273 DME8273 DN 22R-hydroxycholesterol DME8273 MI TTS4UGC DME8273 MN Farnesoid X-activated receptor (FXR) DME8273 MT DTT DME8273 MA Agonist DME8273 RN Oxysterol 22(R)-hydroxycholesterol induces the expression of the bile salt export pump through nuclear receptor farsenoid X receptor but not liver ... J Pharmacol Exp Ther. 2006 Apr;317(1):317-25. DME8273 RU https://pubmed.ncbi.nlm.nih.gov/16371446 DME8273 DI DME8273 DME8273 DN 22R-hydroxycholesterol DME8273 MI TTECBXN DME8273 MN Oxysterols receptor LXR-alpha (NR1H3) DME8273 MT DTT DME8273 MA Agonist DME8273 RN An oxysterol signalling pathway mediated by the nuclear receptor LXR alpha. Nature. 1996 Oct 24;383(6602):728-31. DME8273 RU https://pubmed.ncbi.nlm.nih.gov/8878485 DME8273 DI DME8273 DME8273 DN 22R-hydroxycholesterol DME8273 MI TTXA6PH DME8273 MN Oxysterols receptor LXR-beta (NR1H2) DME8273 MT DTT DME8273 MA Agonist DME8273 RN An oxysterol signalling pathway mediated by the nuclear receptor LXR alpha. Nature. 1996 Oct 24;383(6602):728-31. DME8273 RU https://pubmed.ncbi.nlm.nih.gov/8878485 DM74X5O DI DM74X5O DM74X5O DN 2'-3'-dideoxy-7-deaza-guaninetriphosphate DM74X5O MI TT84ETX DM74X5O MN Human immunodeficiency virus Reverse transcriptase (HIV RT) DM74X5O MT DTT DM74X5O MA Inhibitor DM74X5O RN Synthesis of 2',3'-dideoxynucleoside 5'-alpha-P-borano-beta,gamma-(difluoromethylene)triphosphates and their inhibition of HIV-1 reverse transcript... J Med Chem. 2005 Apr 7;48(7):2695-700. DM74X5O RU https://pubmed.ncbi.nlm.nih.gov/15801860 DM27GH0 DI DM27GH0 DM27GH0 DN 23-hydroxybetulinic acid DM27GH0 MI TTZHY6R DM27GH0 MN Glycogen phosphorylase muscle form (GP) DM27GH0 MT DTT DM27GH0 MA Inhibitor DM27GH0 RN Naturally occurring pentacyclic triterpenes as inhibitors of glycogen phosphorylase: synthesis, structure-activity relationships, and X-ray crystal... J Med Chem. 2008 Jun 26;51(12):3540-54. DM27GH0 RU https://pubmed.ncbi.nlm.nih.gov/18517260 DMW2KI5 DI DMW2KI5 DMW2KI5 DN 24(S), 25-epoxycholesterol DMW2KI5 MI TTECBXN DMW2KI5 MN Oxysterols receptor LXR-alpha (NR1H3) DMW2KI5 MT DTT DMW2KI5 MA Agonist DMW2KI5 RN Brain endogenous liver X receptor ligands selectively promote midbrain neurogenesis. Nat Chem Biol. 2013 Feb;9(2):126-33. DMW2KI5 RU https://pubmed.ncbi.nlm.nih.gov/23292650 DMW2KI5 DI DMW2KI5 DMW2KI5 DN 24(S), 25-epoxycholesterol DMW2KI5 MI TTXA6PH DMW2KI5 MN Oxysterols receptor LXR-beta (NR1H2) DMW2KI5 MT DTT DMW2KI5 MA Agonist DMW2KI5 RN Brain endogenous liver X receptor ligands selectively promote midbrain neurogenesis. Nat Chem Biol. 2013 Feb;9(2):126-33. DMW2KI5 RU https://pubmed.ncbi.nlm.nih.gov/23292650 DMGMWA6 DI DMGMWA6 DMGMWA6 DN 24(S)-hydroxycholesterol DMGMWA6 MI TTECBXN DMGMWA6 MN Oxysterols receptor LXR-alpha (NR1H3) DMGMWA6 MT DTT DMGMWA6 MA Agonist DMGMWA6 RN Activation of the nuclear receptor LXR by oxysterols defines a new hormone response pathway. J Biol Chem. 1997 Feb 7;272(6):3137-40. DMGMWA6 RU https://pubmed.ncbi.nlm.nih.gov/9013544 DMGMWA6 DI DMGMWA6 DMGMWA6 DN 24(S)-hydroxycholesterol DMGMWA6 MI TTXA6PH DMGMWA6 MN Oxysterols receptor LXR-beta (NR1H2) DMGMWA6 MT DTT DMGMWA6 MA Agonist DMGMWA6 RN Activation of the nuclear receptor LXR by oxysterols defines a new hormone response pathway. J Biol Chem. 1997 Feb 7;272(6):3137-40. DMGMWA6 RU https://pubmed.ncbi.nlm.nih.gov/9013544 DMZIQ56 DI DMZIQ56 DMZIQ56 DN 24-ethylcholest-6-ene-3,5-diol DMZIQ56 MI TT1RS9F DMZIQ56 MN Acetylcholinesterase (AChE) DMZIQ56 MT DTT DMZIQ56 MA Inhibitor DMZIQ56 RN Isolation and cholinesterase-inhibition studies of sterols from Haloxylon recurvum. Bioorg Med Chem Lett. 2006 Feb;16(3):573-80. DMZIQ56 RU https://pubmed.ncbi.nlm.nih.gov/16274989 DMZIQ56 DI DMZIQ56 DMZIQ56 DN 24-ethylcholest-6-ene-3,5-diol DMZIQ56 MI TTEB0GD DMZIQ56 MN Cholinesterase (BCHE) DMZIQ56 MT DTT DMZIQ56 MA Inhibitor DMZIQ56 RN Isolation and cholinesterase-inhibition studies of sterols from Haloxylon recurvum. Bioorg Med Chem Lett. 2006 Feb;16(3):573-80. DMZIQ56 RU https://pubmed.ncbi.nlm.nih.gov/16274989 DMQSTYZ DI DMQSTYZ DMQSTYZ DN 24-ethyl-cholest-7-ene-3,5,6-triol DMQSTYZ MI TT1RS9F DMQSTYZ MN Acetylcholinesterase (AChE) DMQSTYZ MT DTT DMQSTYZ MA Inhibitor DMQSTYZ RN Isolation and cholinesterase-inhibition studies of sterols from Haloxylon recurvum. Bioorg Med Chem Lett. 2006 Feb;16(3):573-80. DMQSTYZ RU https://pubmed.ncbi.nlm.nih.gov/16274989 DMQSTYZ DI DMQSTYZ DMQSTYZ DN 24-ethyl-cholest-7-ene-3,5,6-triol DMQSTYZ MI TTEB0GD DMQSTYZ MN Cholinesterase (BCHE) DMQSTYZ MT DTT DMQSTYZ MA Inhibitor DMQSTYZ RN Isolation and cholinesterase-inhibition studies of sterols from Haloxylon recurvum. Bioorg Med Chem Lett. 2006 Feb;16(3):573-80. DMQSTYZ RU https://pubmed.ncbi.nlm.nih.gov/16274989 DMVY271 DI DMVY271 DMVY271 DN 24-hydroxyursolic acid DMVY271 MI TTELIN2 DMVY271 MN PTPN1 messenger RNA (PTPN1 mRNA) DMVY271 MT DTT DMVY271 MA Inhibitor DMVY271 RN Triterpenoids from the leaves of Diospyros kaki (persimmon) and their inhibitory effects on protein tyrosine phosphatase 1B. J Nat Prod. 2008 Oct;71(10):1775-8. DMVY271 RU https://pubmed.ncbi.nlm.nih.gov/18798681 DM90IRW DI DM90IRW DM90IRW DN 24-thiacycloartanol DM90IRW MI TTWQ8IY DM90IRW MN Fungal Sterol 24-C-methyltransferase (Fung erg6) DM90IRW MT DTT DM90IRW MA Inhibitor DM90IRW RN Inactivation of soybean sterol 24-C-methyltransferase by elongated sterol side chains at C26. Bioorg Med Chem Lett. 2007 Nov 1;17(21):5902-6. DM90IRW RU https://pubmed.ncbi.nlm.nih.gov/17851075 DM6P3Z8 DI DM6P3Z8 DM6P3Z8 DN 2'-5'dideoxyuridine DM6P3Z8 MI TTU6BFZ DM6P3Z8 MN Candida Thymidylate synthase (Candi TMP1) DM6P3Z8 MT DTT DM6P3Z8 MA Inhibitor DM6P3Z8 RN DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Nucleic Acids Res. 2011 Jan;39(Database issue):D1035-41. DM6P3Z8 RU https://pubmed.ncbi.nlm.nih.gov/21059682 DMCHAQ7 DI DMCHAQ7 DMCHAQ7 DN 25-hydroxycholesterol DMCHAQ7 MI TTME5YJ DMCHAQ7 MN EBV-induced G-protein coupled receptor 2 (GPR183) DMCHAQ7 MT DTT DMCHAQ7 MA Agonist DMCHAQ7 RN Oxysterols direct B-cell migration through EBI2. Nature. 2011 Jul 27;475(7357):519-23. DMCHAQ7 RU https://pubmed.ncbi.nlm.nih.gov/21796211 DMCHAQ7 DI DMCHAQ7 DMCHAQ7 DN 25-hydroxycholesterol DMCHAQ7 MI TTGV6LY DMCHAQ7 MN Nuclear receptor ROR-gamma (RORG) DMCHAQ7 MT DTT DMCHAQ7 MA Agonist DMCHAQ7 RN Structural basis for hydroxycholesterols as natural ligands of orphan nuclear receptor RORgamma. Mol Endocrinol. 2010 May;24(5):923-9. DMCHAQ7 RU https://pubmed.ncbi.nlm.nih.gov/20203100 DM2L6OZ DI DM2L6OZ DM2L6OZ DN 27-hydroxycholesterol DM2L6OZ MI TTME5YJ DM2L6OZ MN EBV-induced G-protein coupled receptor 2 (GPR183) DM2L6OZ MT DTT DM2L6OZ MA Agonist DM2L6OZ RN Oxysterols direct B-cell migration through EBI2. Nature. 2011 Jul 27;475(7357):519-23. DM2L6OZ RU https://pubmed.ncbi.nlm.nih.gov/21796211 DM2L6OZ DI DM2L6OZ DM2L6OZ DN 27-hydroxycholesterol DM2L6OZ MI TTECBXN DM2L6OZ MN Oxysterols receptor LXR-alpha (NR1H3) DM2L6OZ MT DTT DM2L6OZ MA Agonist DM2L6OZ RN 27-hydroxycholesterol is an endogenous ligand for liver X receptor in cholesterol-loaded cells. J Biol Chem. 2001 Oct 19;276(42):38378-87. DM2L6OZ RU https://pubmed.ncbi.nlm.nih.gov/11504730 DM2L6OZ DI DM2L6OZ DM2L6OZ DN 27-hydroxycholesterol DM2L6OZ MI TTXA6PH DM2L6OZ MN Oxysterols receptor LXR-beta (NR1H2) DM2L6OZ MT DTT DM2L6OZ MA Agonist DM2L6OZ RN 27-hydroxycholesterol is an endogenous ligand for liver X receptor in cholesterol-loaded cells. J Biol Chem. 2001 Oct 19;276(42):38378-87. DM2L6OZ RU https://pubmed.ncbi.nlm.nih.gov/11504730 DMUQAP7 DI DMUQAP7 DMUQAP7 DN 29-methylidene-2,3-oxidosqualene DMUQAP7 MI TT7O8ZA DMUQAP7 MN Lanosterol synthase (LSS) DMUQAP7 MT DTT DMUQAP7 MA Inhibitor DMUQAP7 RN Synthesis and inhibition studies of sulfur-substituted squalene oxide analogues as mechanism-based inhibitors of 2,3-oxidosqualene-lanosterol cyclase. J Med Chem. 1997 Jan 17;40(2):201-9. DMUQAP7 RU https://pubmed.ncbi.nlm.nih.gov/9003518 DMIQM4O DI DMIQM4O DMIQM4O DN 2-acetamido-2,3-dihydro-1H-indene-5-sulfonic acid DMIQM4O MI TTUNARX DMIQM4O MN Carbonic anhydrase (CA) DMIQM4O MT DTT DMIQM4O MA Inhibitor DMIQM4O RN Indanesulfonamides as carbonic anhydrase inhibitors and anticonvulsant agents: structure-activity relationship and pharmacological evaluation. Eur J Med Chem. 2008 Dec;43(12):2853-60. DMIQM4O RU https://pubmed.ncbi.nlm.nih.gov/18406497 DMIQM4O DI DMIQM4O DMIQM4O DN 2-acetamido-2,3-dihydro-1H-indene-5-sulfonic acid DMIQM4O MI TTSYM0R DMIQM4O MN Carbonic anhydrase XII (CA-XII) DMIQM4O MT DTT DMIQM4O MA Inhibitor DMIQM4O RN Indanesulfonamides as carbonic anhydrase inhibitors and anticonvulsant agents: structure-activity relationship and pharmacological evaluation. Eur J Med Chem. 2008 Dec;43(12):2853-60. DMIQM4O RU https://pubmed.ncbi.nlm.nih.gov/18406497 DMIQM4O DI DMIQM4O DMIQM4O DN 2-acetamido-2,3-dihydro-1H-indene-5-sulfonic acid DMIQM4O MI TTEYTKG DMIQM4O MN Carbonic anhydrase XIV (CA-XIV) DMIQM4O MT DTT DMIQM4O MA Inhibitor DMIQM4O RN Indanesulfonamides as carbonic anhydrase inhibitors and anticonvulsant agents: structure-activity relationship and pharmacological evaluation. Eur J Med Chem. 2008 Dec;43(12):2853-60. DMIQM4O RU https://pubmed.ncbi.nlm.nih.gov/18406497 DMPKBVR DI DMPKBVR DMPKBVR DN 2-acetamido-5-sulfonamidoindane DMPKBVR MI TTHQPL7 DMPKBVR MN Carbonic anhydrase I (CA-I) DMPKBVR MT DTT DMPKBVR MA Inhibitor DMPKBVR RN Indanesulfonamides as carbonic anhydrase inhibitors. Toward structure-based design of selective inhibitors of the tumor-associated isozyme CA IX. J Med Chem. 2006 May 4;49(9):2743-9. DMPKBVR RU https://pubmed.ncbi.nlm.nih.gov/16640335 DMPKBVR DI DMPKBVR DMPKBVR DN 2-acetamido-5-sulfonamidoindane DMPKBVR MI TTANPDJ DMPKBVR MN Carbonic anhydrase II (CA-II) DMPKBVR MT DTT DMPKBVR MA Inhibitor DMPKBVR RN Indanesulfonamides as carbonic anhydrase inhibitors. Toward structure-based design of selective inhibitors of the tumor-associated isozyme CA IX. J Med Chem. 2006 May 4;49(9):2743-9. DMPKBVR RU https://pubmed.ncbi.nlm.nih.gov/16640335 DMPKBVR DI DMPKBVR DMPKBVR DN 2-acetamido-5-sulfonamidoindane DMPKBVR MI TT2LVK8 DMPKBVR MN Carbonic anhydrase IX (CA-IX) DMPKBVR MT DTT DMPKBVR MA Inhibitor DMPKBVR RN Indanesulfonamides as carbonic anhydrase inhibitors. Toward structure-based design of selective inhibitors of the tumor-associated isozyme CA IX. J Med Chem. 2006 May 4;49(9):2743-9. DMPKBVR RU https://pubmed.ncbi.nlm.nih.gov/16640335 DMRKYD6 DI DMRKYD6 DMRKYD6 DN 2-acetyl-3-hydroxycyclohex-2-enone DMRKYD6 MI TT8DSFC DMRKYD6 MN Hydroxyphenylpyruvate dioxygenase (HPD) DMRKYD6 MT DTT DMRKYD6 MA Inhibitor DMRKYD6 RN Enzyme inhibition potency enhancement by active site metal chelating and hydrogen bonding induced conformation-restricted cyclopropanecarbonyl deri... Bioorg Med Chem Lett. 2006 Dec 1;16(23):6024-7. DMRKYD6 RU https://pubmed.ncbi.nlm.nih.gov/16979340 DM9ZOX4 DI DM9ZOX4 DM9ZOX4 DN 2-Acetylaminoethyl 18-methoxycoronaridinate DM9ZOX4 MI TTTVAFQ DM9ZOX4 MN Neuronal acetylcholine receptor beta-4 (CHRNB4) DM9ZOX4 MT DTT DM9ZOX4 MA Inhibitor DM9ZOX4 RN Synthesis and biological evaluation of 18-methoxycoronaridine congeners. Potential antiaddiction agents. J Med Chem. 2003 Jun 19;46(13):2716-30. DM9ZOX4 RU https://pubmed.ncbi.nlm.nih.gov/12801235 DMEQKIU DI DMEQKIU DMEQKIU DN 2-Acetylamino-indan-5-sulfonic acid hydrate DMEQKIU MI TTHQPL7 DMEQKIU MN Carbonic anhydrase I (CA-I) DMEQKIU MT DTT DMEQKIU MA Inhibitor DMEQKIU RN Carbonic anhydrase inhibitors. Design of anticonvulsant sulfonamides incorporating indane moieties. Bioorg Med Chem Lett. 2004 Dec 6;14(23):5781-6. DMEQKIU RU https://pubmed.ncbi.nlm.nih.gov/15501040 DMEQKIU DI DMEQKIU DMEQKIU DN 2-Acetylamino-indan-5-sulfonic acid hydrate DMEQKIU MI TTANPDJ DMEQKIU MN Carbonic anhydrase II (CA-II) DMEQKIU MT DTT DMEQKIU MA Inhibitor DMEQKIU RN Carbonic anhydrase inhibitors. Design of anticonvulsant sulfonamides incorporating indane moieties. Bioorg Med Chem Lett. 2004 Dec 6;14(23):5781-6. DMEQKIU RU https://pubmed.ncbi.nlm.nih.gov/15501040 DM0NJYZ DI DM0NJYZ DM0NJYZ DN 2-acetylaminoquinazoline-4-carboxyanilide DM0NJYZ MI TTJFY5U DM0NJYZ MN Adenosine A3 receptor (ADORA3) DM0NJYZ MT DTT DM0NJYZ MA Inhibitor DM0NJYZ RN Scouting human A3 adenosine receptor antagonist binding mode using a molecular simplification approach: from triazoloquinoxaline to a pyrimidine sk... J Med Chem. 2007 Dec 27;50(26):6596-606. DM0NJYZ RU https://pubmed.ncbi.nlm.nih.gov/18047262 DMN8TVB DI DMN8TVB DMN8TVB DN 2-Acetyl-cyclohexane-1,3-dione DMN8TVB MI TT8DSFC DMN8TVB MN Hydroxyphenylpyruvate dioxygenase (HPD) DMN8TVB MT DTT DMN8TVB MA Inhibitor DMN8TVB RN SAR studies of 2-o-substituted-benzoyl- and 2-alkanoyl-cyclohexane-1,3-diones as inhibitors of 4-hydroxyphenylpyruvate dioxygenase. Bioorg Med Chem Lett. 2000 May 1;10(9):843-5. DMN8TVB RU https://pubmed.ncbi.nlm.nih.gov/10853644 DMJAUH0 DI DMJAUH0 DMJAUH0 DN 2-Adamantan-1-yl-N-decyl-acetamide DMJAUH0 MI TT7WVHI DMJAUH0 MN Soluble epoxide hydrolase (EPHX2) DMJAUH0 MT DTT DMJAUH0 MA Inhibitor DMJAUH0 RN Optimization of amide-based inhibitors of soluble epoxide hydrolase with improved water solubility. J Med Chem. 2005 May 19;48(10):3621-9. DMJAUH0 RU https://pubmed.ncbi.nlm.nih.gov/15887969 DMXG029 DI DMXG029 DMXG029 DN 2-Adamantan-2-ylidenemethyl-benzooxazol-6-ol DMXG029 MI TTHM0R1 DMXG029 MN Steryl-sulfatase (STS) DMXG029 MT DTT DMXG029 MA Inhibitor DMXG029 RN Estrone formate: a novel type of irreversible inhibitor of human steroid sulfatase. Bioorg Med Chem Lett. 2004 Oct 4;14(19):4999-5002. DMXG029 RU https://pubmed.ncbi.nlm.nih.gov/15341968 DM3DE9Z DI DM3DE9Z DM3DE9Z DN 2-allylisoquinoline-1,3,4-trione DM3DE9Z MI TTPF2QI DM3DE9Z MN Caspase-3 (CASP3) DM3DE9Z MT DTT DM3DE9Z MA Inhibitor DM3DE9Z RN Design, synthesis, and biological evaluation of isoquinoline-1,3,4-trione derivatives as potent caspase-3 inhibitors. J Med Chem. 2006 Mar 9;49(5):1613-23. DM3DE9Z RU https://pubmed.ncbi.nlm.nih.gov/16509578 DMTO1EJ DI DMTO1EJ DMTO1EJ DN 2-Allylthio-3-benzyl-6-nitro-quinazolin-4(3H)-one DMTO1EJ MI TT9SL3Q DMTO1EJ MN Polypeptide deformylase (PDF) DMTO1EJ MT DTT DMTO1EJ MA Inhibitor DMTO1EJ RN Non-classical antifolates. Part 2: synthesis, biological evaluation, and molecular modeling study of some new 2,6-substituted-quinazolin-4-ones. Bioorg Med Chem. 2010 Apr 15;18(8):2849-63. DMTO1EJ RU https://pubmed.ncbi.nlm.nih.gov/20350811 DMBWGCX DI DMBWGCX DMBWGCX DN 2-Allylthio-6-amino-3-benzyl-quinazolin-4(3H)-one DMBWGCX MI TT9SL3Q DMBWGCX MN Polypeptide deformylase (PDF) DMBWGCX MT DTT DMBWGCX MA Inhibitor DMBWGCX RN Non-classical antifolates. Part 2: synthesis, biological evaluation, and molecular modeling study of some new 2,6-substituted-quinazolin-4-ones. Bioorg Med Chem. 2010 Apr 15;18(8):2849-63. DMBWGCX RU https://pubmed.ncbi.nlm.nih.gov/20350811 DMHY2RA DI DMHY2RA DMHY2RA DN 2alpha-Hydroxyolean-12-en-28-oic acid DMHY2RA MI TTZHY6R DMHY2RA MN Glycogen phosphorylase muscle form (GP) DMHY2RA MT DTT DMHY2RA MA Inhibitor DMHY2RA RN Synthesis of 3-deoxypentacyclic triterpene derivatives as inhibitors of glycogen phosphorylase. J Nat Prod. 2009 Aug;72(8):1414-8. DMHY2RA RU https://pubmed.ncbi.nlm.nih.gov/19642687 DM1RSCP DI DM1RSCP DM1RSCP DN 2alpha-Hydroxyurs-12-en-28-oic acid DM1RSCP MI TTZHY6R DM1RSCP MN Glycogen phosphorylase muscle form (GP) DM1RSCP MT DTT DM1RSCP MA Inhibitor DM1RSCP RN Synthesis of 3-deoxypentacyclic triterpene derivatives as inhibitors of glycogen phosphorylase. J Nat Prod. 2009 Aug;72(8):1414-8. DM1RSCP RU https://pubmed.ncbi.nlm.nih.gov/19642687 DM73FWA DI DM73FWA DM73FWA DN 2-Amino-1-(4-ethylthiophenyl)butane DM73FWA MI TT3ROYC DM73FWA MN Serotonin transporter (SERT) DM73FWA MT DTT DM73FWA MA Inhibitor DM73FWA RN Synthesis and serotonin transporter activity of sulphur-substituted alpha-alkyl phenethylamines as a new class of anticancer agents. Eur J Med Chem. 2009 Dec;44(12):4862-88. DM73FWA RU https://pubmed.ncbi.nlm.nih.gov/19717215 DMS5LKR DI DMS5LKR DMS5LKR DN 2-Amino-1-(4-ethylthiophenyl)propane DMS5LKR MI TT3ROYC DMS5LKR MN Serotonin transporter (SERT) DMS5LKR MT DTT DMS5LKR MA Inhibitor DMS5LKR RN Synthesis and serotonin transporter activity of sulphur-substituted alpha-alkyl phenethylamines as a new class of anticancer agents. Eur J Med Chem. 2009 Dec;44(12):4862-88. DMS5LKR RU https://pubmed.ncbi.nlm.nih.gov/19717215 DMW7N3H DI DMW7N3H DMW7N3H DN 2-Amino-1-(4-methylthiophenyl)butane DMW7N3H MI TT3ROYC DMW7N3H MN Serotonin transporter (SERT) DMW7N3H MT DTT DMW7N3H MA Inhibitor DMW7N3H RN Synthesis and serotonin transporter activity of sulphur-substituted alpha-alkyl phenethylamines as a new class of anticancer agents. Eur J Med Chem. 2009 Dec;44(12):4862-88. DMW7N3H RU https://pubmed.ncbi.nlm.nih.gov/19717215 DMJ2Z9G DI DMJ2Z9G DMJ2Z9G DN 2-Amino-1-(4-methylthiophenyl)propane DMJ2Z9G MI TTVBI8W DMJ2Z9G MN Dopamine transporter (DAT) DMJ2Z9G MT DTT DMJ2Z9G MA Inhibitor DMJ2Z9G RN Synthesis and serotonin transporter activity of sulphur-substituted alpha-alkyl phenethylamines as a new class of anticancer agents. Eur J Med Chem. 2009 Dec;44(12):4862-88. DMJ2Z9G RU https://pubmed.ncbi.nlm.nih.gov/19717215 DMJ2Z9G DI DMJ2Z9G DMJ2Z9G DN 2-Amino-1-(4-methylthiophenyl)propane DMJ2Z9G MI TT3WG5C DMJ2Z9G MN Monoamine oxidase type A (MAO-A) DMJ2Z9G MT DTT DMJ2Z9G MA Inhibitor DMJ2Z9G RN Naphthylisopropylamine and N-benzylamphetamine derivatives as monoamine oxidase inhibitors. Bioorg Med Chem. 2009 Mar 15;17(6):2452-60. DMJ2Z9G RU https://pubmed.ncbi.nlm.nih.gov/19243954 DMJ2Z9G DI DMJ2Z9G DMJ2Z9G DN 2-Amino-1-(4-methylthiophenyl)propane DMJ2Z9G MI TTAWNKZ DMJ2Z9G MN Norepinephrine transporter (NET) DMJ2Z9G MT DTT DMJ2Z9G MA Inhibitor DMJ2Z9G RN Synthesis and serotonin transporter activity of sulphur-substituted alpha-alkyl phenethylamines as a new class of anticancer agents. Eur J Med Chem. 2009 Dec;44(12):4862-88. DMJ2Z9G RU https://pubmed.ncbi.nlm.nih.gov/19717215 DMJ2Z9G DI DMJ2Z9G DMJ2Z9G DN 2-Amino-1-(4-methylthiophenyl)propane DMJ2Z9G MI TT3ROYC DMJ2Z9G MN Serotonin transporter (SERT) DMJ2Z9G MT DTT DMJ2Z9G MA Inhibitor DMJ2Z9G RN Synthesis and serotonin transporter activity of sulphur-substituted alpha-alkyl phenethylamines as a new class of anticancer agents. Eur J Med Chem. 2009 Dec;44(12):4862-88. DMJ2Z9G RU https://pubmed.ncbi.nlm.nih.gov/19717215 DMNQL17 DI DMNQL17 DMNQL17 DN 2-AMINO-1-METHYL-6-PHENYLIMIDAZO[4,5-B]PYRIDINE DMNQL17 MI TTZAYWL DMNQL17 MN Estrogen receptor (ESR) DMNQL17 MT DTT DMNQL17 MA Inhibitor DMNQL17 RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DMNQL17 RU https://pubmed.ncbi.nlm.nih.gov/10592235 DMNQL17 DI DMNQL17 DMNQL17 DN 2-AMINO-1-METHYL-6-PHENYLIMIDAZO[4,5-B]PYRIDINE DMNQL17 MI DE1P7EZ DMNQL17 MN Glycerol/diol dehydratase (dhaB) DMNQL17 MT DME DMNQL17 MA Metabolism DMNQL17 RN Gut microbial beta-glucuronidase and glycerol/diol dehydratase activity contribute to dietary heterocyclic amine biotransformation. BMC Microbiol. 2019 May 16;19(1):99. DMNQL17 RU https://pubmed.ncbi.nlm.nih.gov/31096909 DMNQL17 DI DMNQL17 DMNQL17 DN 2-AMINO-1-METHYL-6-PHENYLIMIDAZO[4,5-B]PYRIDINE DMNQL17 MI DE4ZRTV DMNQL17 MN Glycerol/diol dehydratase (dhaB) DMNQL17 MT DME DMNQL17 MA Metabolism DMNQL17 RN Gut microbial beta-glucuronidase and glycerol/diol dehydratase activity contribute to dietary heterocyclic amine biotransformation. BMC Microbiol. 2019 May 16;19(1):99. DMNQL17 RU https://pubmed.ncbi.nlm.nih.gov/31096909 DMNQL17 DI DMNQL17 DMNQL17 DN 2-AMINO-1-METHYL-6-PHENYLIMIDAZO[4,5-B]PYRIDINE DMNQL17 MI DEW0ADP DMNQL17 MN Glycerol/diol dehydratase (dhaB) DMNQL17 MT DME DMNQL17 MA Metabolism DMNQL17 RN Gut microbial beta-glucuronidase and glycerol/diol dehydratase activity contribute to dietary heterocyclic amine biotransformation. BMC Microbiol. 2019 May 16;19(1):99. DMNQL17 RU https://pubmed.ncbi.nlm.nih.gov/31096909 DMNQL17 DI DMNQL17 DMNQL17 DN 2-AMINO-1-METHYL-6-PHENYLIMIDAZO[4,5-B]PYRIDINE DMNQL17 MI DEIN8FB DMNQL17 MN Glycerol/diol dehydratase (dhaB) DMNQL17 MT DME DMNQL17 MA Metabolism DMNQL17 RN Gut microbial beta-glucuronidase and glycerol/diol dehydratase activity contribute to dietary heterocyclic amine biotransformation. BMC Microbiol. 2019 May 16;19(1):99. DMNQL17 RU https://pubmed.ncbi.nlm.nih.gov/31096909 DMWDENZ DI DMWDENZ DMWDENZ DN 2-amino-2-(2,3-difluorophenyl)acetic acid DMWDENZ MI TTFK1JQ DMWDENZ MN Voltage-gated calcium channel alpha-2/delta-1 (CACNA2D1) DMWDENZ MT DTT DMWDENZ MA Inhibitor DMWDENZ RN Structure-activity relationships of alpha-amino acid ligands for the alpha2delta subunit of voltage-gated calcium channels. Bioorg Med Chem Lett. 2006 Mar 1;16(5):1138-41. DMWDENZ RU https://pubmed.ncbi.nlm.nih.gov/16380257 DMSAFUK DI DMSAFUK DMSAFUK DN 2-amino-2-(2,4-difluorophenyl)acetic acid DMSAFUK MI TTFK1JQ DMSAFUK MN Voltage-gated calcium channel alpha-2/delta-1 (CACNA2D1) DMSAFUK MT DTT DMSAFUK MA Inhibitor DMSAFUK RN Structure-activity relationships of alpha-amino acid ligands for the alpha2delta subunit of voltage-gated calcium channels. Bioorg Med Chem Lett. 2006 Mar 1;16(5):1138-41. DMSAFUK RU https://pubmed.ncbi.nlm.nih.gov/16380257 DMLXOHE DI DMLXOHE DMLXOHE DN 2-amino-2-(2-fluorophenyl)acetic acid DMLXOHE MI TTFK1JQ DMLXOHE MN Voltage-gated calcium channel alpha-2/delta-1 (CACNA2D1) DMLXOHE MT DTT DMLXOHE MA Inhibitor DMLXOHE RN Structure-activity relationships of alpha-amino acid ligands for the alpha2delta subunit of voltage-gated calcium channels. Bioorg Med Chem Lett. 2006 Mar 1;16(5):1138-41. DMLXOHE RU https://pubmed.ncbi.nlm.nih.gov/16380257 DMEX6AM DI DMEX6AM DMEX6AM DN 2-amino-2-(3-bromophenyl)acetic acid DMEX6AM MI TTFK1JQ DMEX6AM MN Voltage-gated calcium channel alpha-2/delta-1 (CACNA2D1) DMEX6AM MT DTT DMEX6AM MA Inhibitor DMEX6AM RN Structure-activity relationships of alpha-amino acid ligands for the alpha2delta subunit of voltage-gated calcium channels. Bioorg Med Chem Lett. 2006 Mar 1;16(5):1138-41. DMEX6AM RU https://pubmed.ncbi.nlm.nih.gov/16380257 DMMU1CQ DI DMMU1CQ DMMU1CQ DN 2-amino-2-(3-chloro-4-fluorophenyl)acetic acid DMMU1CQ MI TTFK1JQ DMMU1CQ MN Voltage-gated calcium channel alpha-2/delta-1 (CACNA2D1) DMMU1CQ MT DTT DMMU1CQ MA Inhibitor DMMU1CQ RN Structure-activity relationships of alpha-amino acid ligands for the alpha2delta subunit of voltage-gated calcium channels. Bioorg Med Chem Lett. 2006 Mar 1;16(5):1138-41. DMMU1CQ RU https://pubmed.ncbi.nlm.nih.gov/16380257 DMPZX8U DI DMPZX8U DMPZX8U DN 2-amino-2-(3-chlorophenyl)acetic acid DMPZX8U MI TTFK1JQ DMPZX8U MN Voltage-gated calcium channel alpha-2/delta-1 (CACNA2D1) DMPZX8U MT DTT DMPZX8U MA Inhibitor DMPZX8U RN Structure-activity relationships of alpha-amino acid ligands for the alpha2delta subunit of voltage-gated calcium channels. Bioorg Med Chem Lett. 2006 Mar 1;16(5):1138-41. DMPZX8U RU https://pubmed.ncbi.nlm.nih.gov/16380257 DMHQNZD DI DMHQNZD DMHQNZD DN 2-amino-2-(thiophen-2-yl)acetic acid DMHQNZD MI TTFK1JQ DMHQNZD MN Voltage-gated calcium channel alpha-2/delta-1 (CACNA2D1) DMHQNZD MT DTT DMHQNZD MA Inhibitor DMHQNZD RN Structure-activity relationships of alpha-amino acid ligands for the alpha2delta subunit of voltage-gated calcium channels. Bioorg Med Chem Lett. 2006 Mar 1;16(5):1138-41. DMHQNZD RU https://pubmed.ncbi.nlm.nih.gov/16380257 DMQOCAY DI DMQOCAY DMQOCAY DN 2-amino-2,3-dihydro-1H-indene-5-sulfonamide DMQOCAY MI TTUNARX DMQOCAY MN Carbonic anhydrase (CA) DMQOCAY MT DTT DMQOCAY MA Inhibitor DMQOCAY RN Indanesulfonamides as carbonic anhydrase inhibitors and anticonvulsant agents: structure-activity relationship and pharmacological evaluation. Eur J Med Chem. 2008 Dec;43(12):2853-60. DMQOCAY RU https://pubmed.ncbi.nlm.nih.gov/18406497 DMQOCAY DI DMQOCAY DMQOCAY DN 2-amino-2,3-dihydro-1H-indene-5-sulfonamide DMQOCAY MI TTSYM0R DMQOCAY MN Carbonic anhydrase XII (CA-XII) DMQOCAY MT DTT DMQOCAY MA Inhibitor DMQOCAY RN Indanesulfonamides as carbonic anhydrase inhibitors and anticonvulsant agents: structure-activity relationship and pharmacological evaluation. Eur J Med Chem. 2008 Dec;43(12):2853-60. DMQOCAY RU https://pubmed.ncbi.nlm.nih.gov/18406497 DMQOCAY DI DMQOCAY DMQOCAY DN 2-amino-2,3-dihydro-1H-indene-5-sulfonamide DMQOCAY MI TTEYTKG DMQOCAY MN Carbonic anhydrase XIV (CA-XIV) DMQOCAY MT DTT DMQOCAY MA Inhibitor DMQOCAY RN Indanesulfonamides as carbonic anhydrase inhibitors and anticonvulsant agents: structure-activity relationship and pharmacological evaluation. Eur J Med Chem. 2008 Dec;43(12):2853-60. DMQOCAY RU https://pubmed.ncbi.nlm.nih.gov/18406497 DM14HCY DI DM14HCY DM14HCY DN 2-amino-2-phenyl-1,1-di(pyridin-3-yl)ethanol DM14HCY MI TTW0CMT DM14HCY MN Voltage-gated potassium channel Kv1.5 (KCNA5) DM14HCY MT DTT DM14HCY MA Inhibitor DM14HCY RN Discovery of triarylethanolamine inhibitors of the Kv1.5 potassium channel. Bioorg Med Chem Lett. 2010 Apr 15;20(8):2493-6. DM14HCY RU https://pubmed.ncbi.nlm.nih.gov/20304642 DMQKGL3 DI DMQKGL3 DMQKGL3 DN 2-AMINO-3-(4-HYDROXY-1,2,5-OXADIAZOL-3-YL)PROPIONIC ACID (STRUCTURAL MIX) DMQKGL3 MI TTAN6JD DMQKGL3 MN Glutamate receptor AMPA (GRIA) DMQKGL3 MT DTT DMQKGL3 MA Inhibitor DMQKGL3 RN 4-hydroxy-1,2,5-oxadiazol-3-yl moiety as bioisoster of the carboxy function. Synthesis, ionization constants, and molecular pharmacological charact... J Med Chem. 2010 May 27;53(10):4110-8. DMQKGL3 RU https://pubmed.ncbi.nlm.nih.gov/20408529 DMQKGL3 DI DMQKGL3 DMQKGL3 DN 2-AMINO-3-(4-HYDROXY-1,2,5-OXADIAZOL-3-YL)PROPIONIC ACID (STRUCTURAL MIX) DMQKGL3 MI TT0MYE2 DMQKGL3 MN Glutamate receptor ionotropic kainate 1 (GRIK1) DMQKGL3 MT DTT DMQKGL3 MA Inhibitor DMQKGL3 RN 4-hydroxy-1,2,5-oxadiazol-3-yl moiety as bioisoster of the carboxy function. Synthesis, ionization constants, and molecular pharmacological charact... J Med Chem. 2010 May 27;53(10):4110-8. DMQKGL3 RU https://pubmed.ncbi.nlm.nih.gov/20408529 DM2GJZE DI DM2GJZE DM2GJZE DN 2-amino-3-(m-tolylamino)naphthalene-1,4-dione DM2GJZE MI TTM2AOE DM2GJZE MN Adenosine A2a receptor (ADORA2A) DM2GJZE MT DTT DM2GJZE MA Inhibitor DM2GJZE RN Structure-based discovery of novel chemotypes for adenosine A(2A) receptor antagonists. J Med Chem. 2010 Feb 25;53(4):1799-809. DM2GJZE RU https://pubmed.ncbi.nlm.nih.gov/20095623 DMUYZA8 DI DMUYZA8 DMUYZA8 DN 2'-amino-3,4,4',5-tetramethoxy-(Z)-stillbene DMUYZA8 MI TTYFKSZ DMUYZA8 MN Tubulin beta (TUBB) DMUYZA8 MT DTT DMUYZA8 MA Inhibitor DMUYZA8 RN 2-amino and 2'-aminocombretastatin derivatives as potent antimitotic agents. J Med Chem. 2006 Oct 19;49(21):6412-5. DMUYZA8 RU https://pubmed.ncbi.nlm.nih.gov/17034147 DMUYZA8 DI DMUYZA8 DMUYZA8 DN 2'-amino-3,4,4',5-tetramethoxy-(Z)-stillbene DMUYZA8 MI TTJ2PTI DMUYZA8 MN Tubulin beta-2 chain (TUBB2) DMUYZA8 MT DTT DMUYZA8 MA Inhibitor DMUYZA8 RN 2-amino and 2'-aminocombretastatin derivatives as potent antimitotic agents. J Med Chem. 2006 Oct 19;49(21):6412-5. DMUYZA8 RU https://pubmed.ncbi.nlm.nih.gov/17034147 DMMZ2LI DI DMMZ2LI DMMZ2LI DN 2-amino-3,4',5-trimethoxy-(Z)-stillbene DMMZ2LI MI TTYFKSZ DMMZ2LI MN Tubulin beta (TUBB) DMMZ2LI MT DTT DMMZ2LI MA Inhibitor DMMZ2LI RN 2-amino and 2'-aminocombretastatin derivatives as potent antimitotic agents. J Med Chem. 2006 Oct 19;49(21):6412-5. DMMZ2LI RU https://pubmed.ncbi.nlm.nih.gov/17034147 DMMZ2LI DI DMMZ2LI DMMZ2LI DN 2-amino-3,4',5-trimethoxy-(Z)-stillbene DMMZ2LI MI TTJ2PTI DMMZ2LI MN Tubulin beta-2 chain (TUBB2) DMMZ2LI MT DTT DMMZ2LI MA Inhibitor DMMZ2LI RN 2-amino and 2'-aminocombretastatin derivatives as potent antimitotic agents. J Med Chem. 2006 Oct 19;49(21):6412-5. DMMZ2LI RU https://pubmed.ncbi.nlm.nih.gov/17034147 DM6AYDL DI DM6AYDL DM6AYDL DN 2-Amino-3-Methyl-1-Pyrrolidin-1-Yl-Butan-1-One DM6AYDL MI TTDIGC1 DM6AYDL MN Dipeptidyl peptidase 4 (DPP-4) DM6AYDL MT DTT DM6AYDL MA Inhibitor DM6AYDL RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DM6AYDL RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMXLZUA DI DMXLZUA DMXLZUA DN 2-Amino-3-Oxo-4-Sulfo-Butyric Acid DMXLZUA MI TTHM0R1 DMXLZUA MN Steryl-sulfatase (STS) DMXLZUA MT DTT DMXLZUA MA Inhibitor DMXLZUA RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMXLZUA RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMTP3LD DI DMTP3LD DMTP3LD DN 2'-amino-4-(1,1-dimethyl-heptyl)-biphenyl-2-ol DMTP3LD MI TT6OEDT DMTP3LD MN Cannabinoid receptor 1 (CB1) DMTP3LD MT DTT DMTP3LD MA Inhibitor DMTP3LD RN Biaryl cannabinoid mimetics--synthesis and structure-activity relationship. Bioorg Med Chem Lett. 2007 Jul 1;17(13):3652-6. DMTP3LD RU https://pubmed.ncbi.nlm.nih.gov/17507224 DMTP3LD DI DMTP3LD DMTP3LD DN 2'-amino-4-(1,1-dimethyl-heptyl)-biphenyl-2-ol DMTP3LD MI TTMSFAW DMTP3LD MN Cannabinoid receptor 2 (CB2) DMTP3LD MT DTT DMTP3LD MA Inhibitor DMTP3LD RN Biaryl cannabinoid mimetics--synthesis and structure-activity relationship. Bioorg Med Chem Lett. 2007 Jul 1;17(13):3652-6. DMTP3LD RU https://pubmed.ncbi.nlm.nih.gov/17507224 DMULSNQ DI DMULSNQ DMULSNQ DN 2-amino-4-(2-methyl-benzylsulfanyl)-butyric acid DMULSNQ MI TTFK1JQ DMULSNQ MN Voltage-gated calcium channel alpha-2/delta-1 (CACNA2D1) DMULSNQ MT DTT DMULSNQ MA Inhibitor DMULSNQ RN Structure-activity relationships of alpha-amino acid ligands for the alpha2delta subunit of voltage-gated calcium channels. Bioorg Med Chem Lett. 2006 Mar 1;16(5):1138-41. DMULSNQ RU https://pubmed.ncbi.nlm.nih.gov/16380257 DMVN0EC DI DMVN0EC DMVN0EC DN 2-Amino-4,6-di-furan-2-yl-nicotinonitrile DMVN0EC MI TTK25J1 DMVN0EC MN Adenosine A1 receptor (ADORA1) DMVN0EC MT DTT DMVN0EC MA Inhibitor DMVN0EC RN 2-Amino-6-furan-2-yl-4-substituted nicotinonitriles as A2A adenosine receptor antagonists. J Med Chem. 2008 Aug 14;51(15):4449-55. DMVN0EC RU https://pubmed.ncbi.nlm.nih.gov/18637670 DMVN0EC DI DMVN0EC DMVN0EC DN 2-Amino-4,6-di-furan-2-yl-nicotinonitrile DMVN0EC MI TTM2AOE DMVN0EC MN Adenosine A2a receptor (ADORA2A) DMVN0EC MT DTT DMVN0EC MA Inhibitor DMVN0EC RN 2-Amino-6-furan-2-yl-4-substituted nicotinonitriles as A2A adenosine receptor antagonists. J Med Chem. 2008 Aug 14;51(15):4449-55. DMVN0EC RU https://pubmed.ncbi.nlm.nih.gov/18637670 DMVN0EC DI DMVN0EC DMVN0EC DN 2-Amino-4,6-di-furan-2-yl-nicotinonitrile DMVN0EC MI TTNE7KG DMVN0EC MN Adenosine A2b receptor (ADORA2B) DMVN0EC MT DTT DMVN0EC MA Inhibitor DMVN0EC RN 2-Amino-6-furan-2-yl-4-substituted nicotinonitriles as A2A adenosine receptor antagonists. J Med Chem. 2008 Aug 14;51(15):4449-55. DMVN0EC RU https://pubmed.ncbi.nlm.nih.gov/18637670 DMVJXQ9 DI DMVJXQ9 DMVJXQ9 DN 2-amino-4,6-dimethylpyridine DMVJXQ9 MI TTZUFI5 DMVJXQ9 MN Nitric-oxide synthase brain (NOS1) DMVJXQ9 MT DTT DMVJXQ9 MA Inhibitor DMVJXQ9 RN L337H mutant of rat neuronal nitric oxide synthase resembles human neuronal nitric oxide synthase toward inhibitors. J Med Chem. 2009 Jul 23;52(14):4533-7. DMVJXQ9 RU https://pubmed.ncbi.nlm.nih.gov/19537690 DMO69TS DI DMO69TS DMO69TS DN 2-Amino-4,6-diphenyl-nicotinonitrile DMO69TS MI TTK25J1 DMO69TS MN Adenosine A1 receptor (ADORA1) DMO69TS MT DTT DMO69TS MA Inhibitor DMO69TS RN 2-Amino-6-furan-2-yl-4-substituted nicotinonitriles as A2A adenosine receptor antagonists. J Med Chem. 2008 Aug 14;51(15):4449-55. DMO69TS RU https://pubmed.ncbi.nlm.nih.gov/18637670 DMO69TS DI DMO69TS DMO69TS DN 2-Amino-4,6-diphenyl-nicotinonitrile DMO69TS MI TTM2AOE DMO69TS MN Adenosine A2a receptor (ADORA2A) DMO69TS MT DTT DMO69TS MA Inhibitor DMO69TS RN 2-Amino-6-furan-2-yl-4-substituted nicotinonitriles as A2A adenosine receptor antagonists. J Med Chem. 2008 Aug 14;51(15):4449-55. DMO69TS RU https://pubmed.ncbi.nlm.nih.gov/18637670 DM1MOB9 DI DM1MOB9 DM1MOB9 DN 2-Amino-4,6-diphenyl-pyrimidin-5-carbonitrile DM1MOB9 MI TTK25J1 DM1MOB9 MN Adenosine A1 receptor (ADORA1) DM1MOB9 MT DTT DM1MOB9 MA Inhibitor DM1MOB9 RN A new generation of adenosine receptor antagonists: from di- to trisubstituted aminopyrimidines. Bioorg Med Chem. 2008 Mar 15;16(6):2741-52. DM1MOB9 RU https://pubmed.ncbi.nlm.nih.gov/18258439 DM1MOB9 DI DM1MOB9 DM1MOB9 DN 2-Amino-4,6-diphenyl-pyrimidin-5-carbonitrile DM1MOB9 MI TTM2AOE DM1MOB9 MN Adenosine A2a receptor (ADORA2A) DM1MOB9 MT DTT DM1MOB9 MA Inhibitor DM1MOB9 RN A new generation of adenosine receptor antagonists: from di- to trisubstituted aminopyrimidines. Bioorg Med Chem. 2008 Mar 15;16(6):2741-52. DM1MOB9 RU https://pubmed.ncbi.nlm.nih.gov/18258439 DMI9YGU DI DMI9YGU DMI9YGU DN 2-Amino-4,6-diphenyl-pyrimidine DMI9YGU MI TTK25J1 DMI9YGU MN Adenosine A1 receptor (ADORA1) DMI9YGU MT DTT DMI9YGU MA Inhibitor DMI9YGU RN A new generation of adenosine receptor antagonists: from di- to trisubstituted aminopyrimidines. Bioorg Med Chem. 2008 Mar 15;16(6):2741-52. DMI9YGU RU https://pubmed.ncbi.nlm.nih.gov/18258439 DMI9YGU DI DMI9YGU DMI9YGU DN 2-Amino-4,6-diphenyl-pyrimidine DMI9YGU MI TTM2AOE DMI9YGU MN Adenosine A2a receptor (ADORA2A) DMI9YGU MT DTT DMI9YGU MA Inhibitor DMI9YGU RN A new generation of adenosine receptor antagonists: from di- to trisubstituted aminopyrimidines. Bioorg Med Chem. 2008 Mar 15;16(6):2741-52. DMI9YGU RU https://pubmed.ncbi.nlm.nih.gov/18258439 DM53T8Q DI DM53T8Q DM53T8Q DN 2-Amino-4,6-di-thiophen-2-yl-nicotinonitrile DM53T8Q MI TTK25J1 DM53T8Q MN Adenosine A1 receptor (ADORA1) DM53T8Q MT DTT DM53T8Q MA Inhibitor DM53T8Q RN 2-Amino-6-furan-2-yl-4-substituted nicotinonitriles as A2A adenosine receptor antagonists. J Med Chem. 2008 Aug 14;51(15):4449-55. DM53T8Q RU https://pubmed.ncbi.nlm.nih.gov/18637670 DM53T8Q DI DM53T8Q DM53T8Q DN 2-Amino-4,6-di-thiophen-2-yl-nicotinonitrile DM53T8Q MI TTM2AOE DM53T8Q MN Adenosine A2a receptor (ADORA2A) DM53T8Q MT DTT DM53T8Q MA Inhibitor DM53T8Q RN 2-Amino-6-furan-2-yl-4-substituted nicotinonitriles as A2A adenosine receptor antagonists. J Med Chem. 2008 Aug 14;51(15):4449-55. DM53T8Q RU https://pubmed.ncbi.nlm.nih.gov/18637670 DMP4NHD DI DMP4NHD DMP4NHD DN 2-Amino-4-furan-2-yl-6-phenyl-nicotinonitrile DMP4NHD MI TTK25J1 DMP4NHD MN Adenosine A1 receptor (ADORA1) DMP4NHD MT DTT DMP4NHD MA Inhibitor DMP4NHD RN 2-Amino-6-furan-2-yl-4-substituted nicotinonitriles as A2A adenosine receptor antagonists. J Med Chem. 2008 Aug 14;51(15):4449-55. DMP4NHD RU https://pubmed.ncbi.nlm.nih.gov/18637670 DMP4NHD DI DMP4NHD DMP4NHD DN 2-Amino-4-furan-2-yl-6-phenyl-nicotinonitrile DMP4NHD MI TTM2AOE DMP4NHD MN Adenosine A2a receptor (ADORA2A) DMP4NHD MT DTT DMP4NHD MA Inhibitor DMP4NHD RN 2-Amino-6-furan-2-yl-4-substituted nicotinonitriles as A2A adenosine receptor antagonists. J Med Chem. 2008 Aug 14;51(15):4449-55. DMP4NHD RU https://pubmed.ncbi.nlm.nih.gov/18637670 DMP4NHD DI DMP4NHD DMP4NHD DN 2-Amino-4-furan-2-yl-6-phenyl-nicotinonitrile DMP4NHD MI TTNE7KG DMP4NHD MN Adenosine A2b receptor (ADORA2B) DMP4NHD MT DTT DMP4NHD MA Inhibitor DMP4NHD RN 2-Amino-6-furan-2-yl-4-substituted nicotinonitriles as A2A adenosine receptor antagonists. J Med Chem. 2008 Aug 14;51(15):4449-55. DMP4NHD RU https://pubmed.ncbi.nlm.nih.gov/18637670 DM1OED2 DI DM1OED2 DM1OED2 DN 2-amino-4-methylpyridine DM1OED2 MI TTZUFI5 DM1OED2 MN Nitric-oxide synthase brain (NOS1) DM1OED2 MT DTT DM1OED2 MA Inhibitor DM1OED2 RN Anchored plasticity opens doors for selective inhibitor design in nitric oxide synthase. Nat Chem Biol. 2008 Nov;4(11):700-7. DM1OED2 RU https://pubmed.ncbi.nlm.nih.gov/18849972 DM1OED2 DI DM1OED2 DM1OED2 DN 2-amino-4-methylpyridine DM1OED2 MI TTCM4B3 DM1OED2 MN Nitric-oxide synthase endothelial (NOS3) DM1OED2 MT DTT DM1OED2 MA Inhibitor DM1OED2 RN Anchored plasticity opens doors for selective inhibitor design in nitric oxide synthase. Nat Chem Biol. 2008 Nov;4(11):700-7. DM1OED2 RU https://pubmed.ncbi.nlm.nih.gov/18849972 DM1OED2 DI DM1OED2 DM1OED2 DN 2-amino-4-methylpyridine DM1OED2 MI TTF10I9 DM1OED2 MN Nitric-oxide synthase inducible (NOS2) DM1OED2 MT DTT DM1OED2 MA Inhibitor DM1OED2 RN 2-Amino-4-methylpyridine as a potent inhibitor of inducible NO synthase activity in vitro and in vivo. Br J Pharmacol. 1996 Nov;119(6):1101-8. DM1OED2 RU https://pubmed.ncbi.nlm.nih.gov/8937711 DMRVTJ1 DI DMRVTJ1 DMRVTJ1 DN 2-Amino-4-phenyl-6-thiophen-2-yl-nicotinonitrile DMRVTJ1 MI TTK25J1 DMRVTJ1 MN Adenosine A1 receptor (ADORA1) DMRVTJ1 MT DTT DMRVTJ1 MA Inhibitor DMRVTJ1 RN 2-Amino-6-furan-2-yl-4-substituted nicotinonitriles as A2A adenosine receptor antagonists. J Med Chem. 2008 Aug 14;51(15):4449-55. DMRVTJ1 RU https://pubmed.ncbi.nlm.nih.gov/18637670 DMRVTJ1 DI DMRVTJ1 DMRVTJ1 DN 2-Amino-4-phenyl-6-thiophen-2-yl-nicotinonitrile DMRVTJ1 MI TTM2AOE DMRVTJ1 MN Adenosine A2a receptor (ADORA2A) DMRVTJ1 MT DTT DMRVTJ1 MA Inhibitor DMRVTJ1 RN 2-Amino-6-furan-2-yl-4-substituted nicotinonitriles as A2A adenosine receptor antagonists. J Med Chem. 2008 Aug 14;51(15):4449-55. DMRVTJ1 RU https://pubmed.ncbi.nlm.nih.gov/18637670 DMOIZY1 DI DMOIZY1 DMOIZY1 DN 2-Amino-4-phosphono-butyric acid DMOIZY1 MI TT0IFKL DMOIZY1 MN Metabotropic glutamate receptor 8 (mGluR8) DMOIZY1 MT DTT DMOIZY1 MA Inhibitor DMOIZY1 RN (2S,1'S,2'R,3'R)-2(2'-Carboxy-3'-hydroxymethylcyclopropyl)glycine-[3H], a potent and selective radioligand for labeling group 2 and 3 metabotropic ... Bioorg Med Chem Lett. 2005 Jan 17;15(2):349-51. DMOIZY1 RU https://pubmed.ncbi.nlm.nih.gov/15603952 DMDUZ2H DI DMDUZ2H DMDUZ2H DN 2-Amino-5-(N-nitro-guanidino)-pentanoic acid DMDUZ2H MI TTZUFI5 DMDUZ2H MN Nitric-oxide synthase brain (NOS1) DMDUZ2H MT DTT DMDUZ2H MA Inhibitor DMDUZ2H RN 2-Iminopiperidine and other 2-iminoazaheterocycles as potent inhibitors of human nitric oxide synthase isoforms. J Med Chem. 1996 Feb 2;39(3):669-72. DMDUZ2H RU https://pubmed.ncbi.nlm.nih.gov/8576908 DMDUZ2H DI DMDUZ2H DMDUZ2H DN 2-Amino-5-(N-nitro-guanidino)-pentanoic acid DMDUZ2H MI TTCM4B3 DMDUZ2H MN Nitric-oxide synthase endothelial (NOS3) DMDUZ2H MT DTT DMDUZ2H MA Inhibitor DMDUZ2H RN 2-Iminopiperidine and other 2-iminoazaheterocycles as potent inhibitors of human nitric oxide synthase isoforms. J Med Chem. 1996 Feb 2;39(3):669-72. DMDUZ2H RU https://pubmed.ncbi.nlm.nih.gov/8576908 DMDUZ2H DI DMDUZ2H DMDUZ2H DN 2-Amino-5-(N-nitro-guanidino)-pentanoic acid DMDUZ2H MI TTF10I9 DMDUZ2H MN Nitric-oxide synthase inducible (NOS2) DMDUZ2H MT DTT DMDUZ2H MA Inhibitor DMDUZ2H RN 2-Iminopiperidine and other 2-iminoazaheterocycles as potent inhibitors of human nitric oxide synthase isoforms. J Med Chem. 1996 Feb 2;39(3):669-72. DMDUZ2H RU https://pubmed.ncbi.nlm.nih.gov/8576908 DMA7ZOW DI DMA7ZOW DMA7ZOW DN 2-Amino-5-Hydroxy-Benzimidazole DMA7ZOW MI TTGY7WI DMA7ZOW MN Urokinase-type plasminogen activator (PLAU) DMA7ZOW MT DTT DMA7ZOW MA Inhibitor DMA7ZOW RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMA7ZOW RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMOQ2R8 DI DMOQ2R8 DMOQ2R8 DN 2-amino-5-phenylthiophene-3-carboxamide DMOQ2R8 MI TTJ3E9X DMOQ2R8 MN Inhibitor of nuclear factor kappa-B kinase beta (IKKB) DMOQ2R8 MT DTT DMOQ2R8 MA Inhibitor DMOQ2R8 RN Evolution of the thienopyridine class of inhibitors of IkappaB kinase-beta: part I: hit-to-lead strategies. J Med Chem. 2006 May 18;49(10):2898-908. DMOQ2R8 RU https://pubmed.ncbi.nlm.nih.gov/16686533 DM3VJEZ DI DM3VJEZ DM3VJEZ DN 2-Amino-6-(2-bromo-benzenesulfonyl)-benzonitrile DM3VJEZ MI TT84ETX DM3VJEZ MN Human immunodeficiency virus Reverse transcriptase (HIV RT) DM3VJEZ MT DTT DM3VJEZ MA Inhibitor DM3VJEZ RN 2-Amino-6-arylsulfonylbenzonitriles as non-nucleoside reverse transcriptase inhibitors of HIV-1. J Med Chem. 2001 Jun 7;44(12):1866-82. DM3VJEZ RU https://pubmed.ncbi.nlm.nih.gov/11384233 DMFW9D3 DI DMFW9D3 DMFW9D3 DN 2-Amino-6-(2-chloro-benzenesulfonyl)-benzonitrile DMFW9D3 MI TT84ETX DMFW9D3 MN Human immunodeficiency virus Reverse transcriptase (HIV RT) DMFW9D3 MT DTT DMFW9D3 MA Inhibitor DMFW9D3 RN 2-Amino-6-arylsulfonylbenzonitriles as non-nucleoside reverse transcriptase inhibitors of HIV-1. J Med Chem. 2001 Jun 7;44(12):1866-82. DMFW9D3 RU https://pubmed.ncbi.nlm.nih.gov/11384233 DM7391H DI DM7391H DM7391H DN 2-Amino-6-(2-chloro-phenylsulfanyl)-benzonitrile DM7391H MI TT84ETX DM7391H MN Human immunodeficiency virus Reverse transcriptase (HIV RT) DM7391H MT DTT DM7391H MA Inhibitor DM7391H RN 2-Amino-6-arylsulfonylbenzonitriles as non-nucleoside reverse transcriptase inhibitors of HIV-1. J Med Chem. 2001 Jun 7;44(12):1866-82. DM7391H RU https://pubmed.ncbi.nlm.nih.gov/11384233 DM8O6AC DI DM8O6AC DM8O6AC DN 2-Amino-6-(2-cyano-benzenesulfinyl)-benzonitrile DM8O6AC MI TT84ETX DM8O6AC MN Human immunodeficiency virus Reverse transcriptase (HIV RT) DM8O6AC MT DTT DM8O6AC MA Inhibitor DM8O6AC RN 2-Amino-6-arylsulfonylbenzonitriles as non-nucleoside reverse transcriptase inhibitors of HIV-1. J Med Chem. 2001 Jun 7;44(12):1866-82. DM8O6AC RU https://pubmed.ncbi.nlm.nih.gov/11384233 DMRKQLV DI DMRKQLV DMRKQLV DN 2-Amino-6-(2-cyano-benzenesulfonyl)-benzonitrile DMRKQLV MI TT84ETX DMRKQLV MN Human immunodeficiency virus Reverse transcriptase (HIV RT) DMRKQLV MT DTT DMRKQLV MA Inhibitor DMRKQLV RN 2-Amino-6-arylsulfonylbenzonitriles as non-nucleoside reverse transcriptase inhibitors of HIV-1. J Med Chem. 2001 Jun 7;44(12):1866-82. DMRKQLV RU https://pubmed.ncbi.nlm.nih.gov/11384233 DM8UQD5 DI DM8UQD5 DM8UQD5 DN 2-Amino-6-(2-cyano-phenylsulfanyl)-benzonitrile DM8UQD5 MI TT84ETX DM8UQD5 MN Human immunodeficiency virus Reverse transcriptase (HIV RT) DM8UQD5 MT DTT DM8UQD5 MA Inhibitor DM8UQD5 RN 2-Amino-6-arylsulfonylbenzonitriles as non-nucleoside reverse transcriptase inhibitors of HIV-1. J Med Chem. 2001 Jun 7;44(12):1866-82. DM8UQD5 RU https://pubmed.ncbi.nlm.nih.gov/11384233 DMBMK8S DI DMBMK8S DMBMK8S DN 2-Amino-6-(2-fluoro-benzenesulfonyl)-benzonitrile DMBMK8S MI TT84ETX DMBMK8S MN Human immunodeficiency virus Reverse transcriptase (HIV RT) DMBMK8S MT DTT DMBMK8S MA Inhibitor DMBMK8S RN 2-Amino-6-arylsulfonylbenzonitriles as non-nucleoside reverse transcriptase inhibitors of HIV-1. J Med Chem. 2001 Jun 7;44(12):1866-82. DMBMK8S RU https://pubmed.ncbi.nlm.nih.gov/11384233 DM0N5J4 DI DM0N5J4 DM0N5J4 DN 2-Amino-6-(2-methoxy-phenylsulfanyl)-benzonitrile DM0N5J4 MI TT84ETX DM0N5J4 MN Human immunodeficiency virus Reverse transcriptase (HIV RT) DM0N5J4 MT DTT DM0N5J4 MA Inhibitor DM0N5J4 RN 2-Amino-6-arylsulfonylbenzonitriles as non-nucleoside reverse transcriptase inhibitors of HIV-1. J Med Chem. 2001 Jun 7;44(12):1866-82. DM0N5J4 RU https://pubmed.ncbi.nlm.nih.gov/11384233 DM6R98Y DI DM6R98Y DM6R98Y DN 2-Amino-6-(3-bromo-benzenesulfinyl)-benzonitrile DM6R98Y MI TT84ETX DM6R98Y MN Human immunodeficiency virus Reverse transcriptase (HIV RT) DM6R98Y MT DTT DM6R98Y MA Inhibitor DM6R98Y RN 2-Amino-6-arylsulfonylbenzonitriles as non-nucleoside reverse transcriptase inhibitors of HIV-1. J Med Chem. 2001 Jun 7;44(12):1866-82. DM6R98Y RU https://pubmed.ncbi.nlm.nih.gov/11384233 DMTUM78 DI DMTUM78 DMTUM78 DN 2-Amino-6-(3-bromo-benzenesulfonyl)-benzonitrile DMTUM78 MI TT84ETX DMTUM78 MN Human immunodeficiency virus Reverse transcriptase (HIV RT) DMTUM78 MT DTT DMTUM78 MA Inhibitor DMTUM78 RN 2-Amino-6-arylsulfonylbenzonitriles as non-nucleoside reverse transcriptase inhibitors of HIV-1. J Med Chem. 2001 Jun 7;44(12):1866-82. DMTUM78 RU https://pubmed.ncbi.nlm.nih.gov/11384233 DMH4TRD DI DMH4TRD DMH4TRD DN 2-Amino-6-(3-bromo-phenylsulfanyl)-benzonitrile DMH4TRD MI TT84ETX DMH4TRD MN Human immunodeficiency virus Reverse transcriptase (HIV RT) DMH4TRD MT DTT DMH4TRD MA Inhibitor DMH4TRD RN 2-Amino-6-arylsulfonylbenzonitriles as non-nucleoside reverse transcriptase inhibitors of HIV-1. J Med Chem. 2001 Jun 7;44(12):1866-82. DMH4TRD RU https://pubmed.ncbi.nlm.nih.gov/11384233 DM9XKJQ DI DM9XKJQ DM9XKJQ DN 2-Amino-6-(3-chloro-benzenesulfonyl)-benzonitrile DM9XKJQ MI TT84ETX DM9XKJQ MN Human immunodeficiency virus Reverse transcriptase (HIV RT) DM9XKJQ MT DTT DM9XKJQ MA Inhibitor DM9XKJQ RN 2-Amino-6-arylsulfonylbenzonitriles as non-nucleoside reverse transcriptase inhibitors of HIV-1. J Med Chem. 2001 Jun 7;44(12):1866-82. DM9XKJQ RU https://pubmed.ncbi.nlm.nih.gov/11384233 DMT3KP0 DI DMT3KP0 DMT3KP0 DN 2-Amino-6-(3-chloro-phenylsulfanyl)-benzonitrile DMT3KP0 MI TT84ETX DMT3KP0 MN Human immunodeficiency virus Reverse transcriptase (HIV RT) DMT3KP0 MT DTT DMT3KP0 MA Inhibitor DMT3KP0 RN 2-Amino-6-arylsulfonylbenzonitriles as non-nucleoside reverse transcriptase inhibitors of HIV-1. J Med Chem. 2001 Jun 7;44(12):1866-82. DMT3KP0 RU https://pubmed.ncbi.nlm.nih.gov/11384233 DM9GQ1U DI DM9GQ1U DM9GQ1U DN 2-Amino-6-(3-cyano-benzenesulfonyl)-benzonitrile DM9GQ1U MI TT84ETX DM9GQ1U MN Human immunodeficiency virus Reverse transcriptase (HIV RT) DM9GQ1U MT DTT DM9GQ1U MA Inhibitor DM9GQ1U RN 2-Amino-6-arylsulfonylbenzonitriles as non-nucleoside reverse transcriptase inhibitors of HIV-1. J Med Chem. 2001 Jun 7;44(12):1866-82. DM9GQ1U RU https://pubmed.ncbi.nlm.nih.gov/11384233 DM2MCK1 DI DM2MCK1 DM2MCK1 DN 2-Amino-6-(3-cyano-phenylsulfanyl)-benzonitrile DM2MCK1 MI TT84ETX DM2MCK1 MN Human immunodeficiency virus Reverse transcriptase (HIV RT) DM2MCK1 MT DTT DM2MCK1 MA Inhibitor DM2MCK1 RN 2-Amino-6-arylsulfonylbenzonitriles as non-nucleoside reverse transcriptase inhibitors of HIV-1. J Med Chem. 2001 Jun 7;44(12):1866-82. DM2MCK1 RU https://pubmed.ncbi.nlm.nih.gov/11384233 DMG7HP2 DI DMG7HP2 DMG7HP2 DN 2-Amino-6-(3-fluoro-phenylsulfanyl)-benzonitrile DMG7HP2 MI TT84ETX DMG7HP2 MN Human immunodeficiency virus Reverse transcriptase (HIV RT) DMG7HP2 MT DTT DMG7HP2 MA Inhibitor DMG7HP2 RN 2-Amino-6-arylsulfonylbenzonitriles as non-nucleoside reverse transcriptase inhibitors of HIV-1. J Med Chem. 2001 Jun 7;44(12):1866-82. DMG7HP2 RU https://pubmed.ncbi.nlm.nih.gov/11384233 DMACYWZ DI DMACYWZ DMACYWZ DN 2-Amino-6-(3-methoxy-phenylsulfanyl)-benzonitrile DMACYWZ MI TT84ETX DMACYWZ MN Human immunodeficiency virus Reverse transcriptase (HIV RT) DMACYWZ MT DTT DMACYWZ MA Inhibitor DMACYWZ RN 2-Amino-6-arylsulfonylbenzonitriles as non-nucleoside reverse transcriptase inhibitors of HIV-1. J Med Chem. 2001 Jun 7;44(12):1866-82. DMACYWZ RU https://pubmed.ncbi.nlm.nih.gov/11384233 DML6EFV DI DML6EFV DML6EFV DN 2-Amino-6-(4-chloro-phenylsulfanyl)-benzonitrile DML6EFV MI TT84ETX DML6EFV MN Human immunodeficiency virus Reverse transcriptase (HIV RT) DML6EFV MT DTT DML6EFV MA Inhibitor DML6EFV RN 2-Amino-6-arylsulfonylbenzonitriles as non-nucleoside reverse transcriptase inhibitors of HIV-1. J Med Chem. 2001 Jun 7;44(12):1866-82. DML6EFV RU https://pubmed.ncbi.nlm.nih.gov/11384233 DMECHD0 DI DMECHD0 DMECHD0 DN 2-Amino-6-(indan-5-ylamino)-3H-pyrimidin-4-one DMECHD0 MI TT2GPK3 DMECHD0 MN DNA topoisomerase (TOP) DMECHD0 MT DTT DMECHD0 MA Inhibitor DMECHD0 RN Inhibitors of Bacillus subtilis DNA polymerase III. Influence of modifications in the pyrimidine ring of anilino- and (benzylamino)pyrimidines. J Med Chem. 1986 May;29(5):676-81. DMECHD0 RU https://pubmed.ncbi.nlm.nih.gov/3084785 DMXPWHF DI DMXPWHF DMXPWHF DN 2-Amino-6-(naphthalene-1-sulfonyl)-benzonitrile DMXPWHF MI TT84ETX DMXPWHF MN Human immunodeficiency virus Reverse transcriptase (HIV RT) DMXPWHF MT DTT DMXPWHF MA Inhibitor DMXPWHF RN 2-Amino-6-arylsulfonylbenzonitriles as non-nucleoside reverse transcriptase inhibitors of HIV-1. J Med Chem. 2001 Jun 7;44(12):1866-82. DMXPWHF RU https://pubmed.ncbi.nlm.nih.gov/11384233 DMMKJYG DI DMMKJYG DMMKJYG DN 2-Amino-6-(naphthalene-2-sulfonyl)-benzonitrile DMMKJYG MI TT84ETX DMMKJYG MN Human immunodeficiency virus Reverse transcriptase (HIV RT) DMMKJYG MT DTT DMMKJYG MA Inhibitor DMMKJYG RN 2-Amino-6-arylsulfonylbenzonitriles as non-nucleoside reverse transcriptase inhibitors of HIV-1. J Med Chem. 2001 Jun 7;44(12):1866-82. DMMKJYG RU https://pubmed.ncbi.nlm.nih.gov/11384233 DMWGE3U DI DMWGE3U DMWGE3U DN 2-Amino-6-(toluene-2-sulfonyl)-benzonitrile DMWGE3U MI TT84ETX DMWGE3U MN Human immunodeficiency virus Reverse transcriptase (HIV RT) DMWGE3U MT DTT DMWGE3U MA Inhibitor DMWGE3U RN 2-Amino-6-arylsulfonylbenzonitriles as non-nucleoside reverse transcriptase inhibitors of HIV-1. J Med Chem. 2001 Jun 7;44(12):1866-82. DMWGE3U RU https://pubmed.ncbi.nlm.nih.gov/11384233 DMJXWH0 DI DMJXWH0 DMJXWH0 DN 2-Amino-6-(toluene-3-sulfinyl)-benzonitrile DMJXWH0 MI TT84ETX DMJXWH0 MN Human immunodeficiency virus Reverse transcriptase (HIV RT) DMJXWH0 MT DTT DMJXWH0 MA Inhibitor DMJXWH0 RN 2-Amino-6-arylsulfonylbenzonitriles as non-nucleoside reverse transcriptase inhibitors of HIV-1. J Med Chem. 2001 Jun 7;44(12):1866-82. DMJXWH0 RU https://pubmed.ncbi.nlm.nih.gov/11384233 DM1EGP9 DI DM1EGP9 DM1EGP9 DN 2-Amino-6-(toluene-3-sulfonyl)-benzonitrile DM1EGP9 MI TT84ETX DM1EGP9 MN Human immunodeficiency virus Reverse transcriptase (HIV RT) DM1EGP9 MT DTT DM1EGP9 MA Inhibitor DM1EGP9 RN 2-Amino-6-arylsulfonylbenzonitriles as non-nucleoside reverse transcriptase inhibitors of HIV-1. J Med Chem. 2001 Jun 7;44(12):1866-82. DM1EGP9 RU https://pubmed.ncbi.nlm.nih.gov/11384233 DMB7415 DI DMB7415 DMB7415 DN 2-Amino-6-(toluene-4-sulfonyl)-benzonitrile DMB7415 MI TT84ETX DMB7415 MN Human immunodeficiency virus Reverse transcriptase (HIV RT) DMB7415 MT DTT DMB7415 MA Inhibitor DMB7415 RN 2-Amino-6-arylsulfonylbenzonitriles as non-nucleoside reverse transcriptase inhibitors of HIV-1. J Med Chem. 2001 Jun 7;44(12):1866-82. DMB7415 RU https://pubmed.ncbi.nlm.nih.gov/11384233 DMJ4H9F DI DMJ4H9F DMJ4H9F DN 2-Amino-6-benzenesulfonyl-benzonitrile DMJ4H9F MI TT84ETX DMJ4H9F MN Human immunodeficiency virus Reverse transcriptase (HIV RT) DMJ4H9F MT DTT DMJ4H9F MA Inhibitor DMJ4H9F RN 2-Amino-6-arylsulfonylbenzonitriles as non-nucleoside reverse transcriptase inhibitors of HIV-1. J Med Chem. 2001 Jun 7;44(12):1866-82. DMJ4H9F RU https://pubmed.ncbi.nlm.nih.gov/11384233 DMJVG30 DI DMJVG30 DMJVG30 DN 2-Amino-6-Chloropyrazine DMJVG30 MI TT7HF4W DMJVG30 MN Cyclin-dependent kinase 2 (CDK2) DMJVG30 MT DTT DMJVG30 MA Inhibitor DMJVG30 RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMJVG30 RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMUYTXS DI DMUYTXS DMUYTXS DN 2-Amino-6-furan-2-yl-4-phenyl-nicotinonitrile DMUYTXS MI TTK25J1 DMUYTXS MN Adenosine A1 receptor (ADORA1) DMUYTXS MT DTT DMUYTXS MA Inhibitor DMUYTXS RN 2-Amino-6-furan-2-yl-4-substituted nicotinonitriles as A2A adenosine receptor antagonists. J Med Chem. 2008 Aug 14;51(15):4449-55. DMUYTXS RU https://pubmed.ncbi.nlm.nih.gov/18637670 DMUYTXS DI DMUYTXS DMUYTXS DN 2-Amino-6-furan-2-yl-4-phenyl-nicotinonitrile DMUYTXS MI TTM2AOE DMUYTXS MN Adenosine A2a receptor (ADORA2A) DMUYTXS MT DTT DMUYTXS MA Inhibitor DMUYTXS RN 2-Amino-6-furan-2-yl-4-substituted nicotinonitriles as A2A adenosine receptor antagonists. J Med Chem. 2008 Aug 14;51(15):4449-55. DMUYTXS RU https://pubmed.ncbi.nlm.nih.gov/18637670 DMUYTXS DI DMUYTXS DMUYTXS DN 2-Amino-6-furan-2-yl-4-phenyl-nicotinonitrile DMUYTXS MI TTNE7KG DMUYTXS MN Adenosine A2b receptor (ADORA2B) DMUYTXS MT DTT DMUYTXS MA Inhibitor DMUYTXS RN 2-Amino-6-furan-2-yl-4-substituted nicotinonitriles as A2A adenosine receptor antagonists. J Med Chem. 2008 Aug 14;51(15):4449-55. DMUYTXS RU https://pubmed.ncbi.nlm.nih.gov/18637670 DMQF9H1 DI DMQF9H1 DMQF9H1 DN 2-Amino-6-m-tolylsulfanyl-benzonitrile DMQF9H1 MI TT84ETX DMQF9H1 MN Human immunodeficiency virus Reverse transcriptase (HIV RT) DMQF9H1 MT DTT DMQF9H1 MA Inhibitor DMQF9H1 RN 2-Amino-6-arylsulfonylbenzonitriles as non-nucleoside reverse transcriptase inhibitors of HIV-1. J Med Chem. 2001 Jun 7;44(12):1866-82. DMQF9H1 RU https://pubmed.ncbi.nlm.nih.gov/11384233 DMAXESK DI DMAXESK DMAXESK DN 2-amino-6-phenyl-4-p-tolylnicotinonitrile DMAXESK MI TTK25J1 DMAXESK MN Adenosine A1 receptor (ADORA1) DMAXESK MT DTT DMAXESK MA Inhibitor DMAXESK RN Identification of non-furan containing A2A antagonists using database mining and molecular similarity approaches. Bioorg Med Chem Lett. 2006 Dec 1;16(23):5993-7. DMAXESK RU https://pubmed.ncbi.nlm.nih.gov/16971117 DMAXESK DI DMAXESK DMAXESK DN 2-amino-6-phenyl-4-p-tolylnicotinonitrile DMAXESK MI TTM2AOE DMAXESK MN Adenosine A2a receptor (ADORA2A) DMAXESK MT DTT DMAXESK MA Inhibitor DMAXESK RN Identification of non-furan containing A2A antagonists using database mining and molecular similarity approaches. Bioorg Med Chem Lett. 2006 Dec 1;16(23):5993-7. DMAXESK RU https://pubmed.ncbi.nlm.nih.gov/16971117 DM7M9CL DI DM7M9CL DM7M9CL DN 2-Amino-6-phenyl-4-thiophen-2-yl-nicotinonitrile DM7M9CL MI TTK25J1 DM7M9CL MN Adenosine A1 receptor (ADORA1) DM7M9CL MT DTT DM7M9CL MA Inhibitor DM7M9CL RN 2-Amino-6-furan-2-yl-4-substituted nicotinonitriles as A2A adenosine receptor antagonists. J Med Chem. 2008 Aug 14;51(15):4449-55. DM7M9CL RU https://pubmed.ncbi.nlm.nih.gov/18637670 DM7M9CL DI DM7M9CL DM7M9CL DN 2-Amino-6-phenyl-4-thiophen-2-yl-nicotinonitrile DM7M9CL MI TTM2AOE DM7M9CL MN Adenosine A2a receptor (ADORA2A) DM7M9CL MT DTT DM7M9CL MA Inhibitor DM7M9CL RN 2-Amino-6-furan-2-yl-4-substituted nicotinonitriles as A2A adenosine receptor antagonists. J Med Chem. 2008 Aug 14;51(15):4449-55. DM7M9CL RU https://pubmed.ncbi.nlm.nih.gov/18637670 DMMBGK0 DI DMMBGK0 DMMBGK0 DN 2-Amino-6-phenylsulfanyl-benzonitrile DMMBGK0 MI TT84ETX DMMBGK0 MN Human immunodeficiency virus Reverse transcriptase (HIV RT) DMMBGK0 MT DTT DMMBGK0 MA Inhibitor DMMBGK0 RN 2-Amino-6-arylsulfonylbenzonitriles as non-nucleoside reverse transcriptase inhibitors of HIV-1. J Med Chem. 2001 Jun 7;44(12):1866-82. DMMBGK0 RU https://pubmed.ncbi.nlm.nih.gov/11384233 DM4BQ1W DI DM4BQ1W DM4BQ1W DN 2-Amino-6-p-tolylsulfanyl-benzonitrile DM4BQ1W MI TT84ETX DM4BQ1W MN Human immunodeficiency virus Reverse transcriptase (HIV RT) DM4BQ1W MT DTT DM4BQ1W MA Inhibitor DM4BQ1W RN 2-Amino-6-arylsulfonylbenzonitriles as non-nucleoside reverse transcriptase inhibitors of HIV-1. J Med Chem. 2001 Jun 7;44(12):1866-82. DM4BQ1W RU https://pubmed.ncbi.nlm.nih.gov/11384233 DMRSGC5 DI DMRSGC5 DMRSGC5 DN 2-amino-8-methyl-7,8-dihydropteridin-4(3H)-one DMRSGC5 MI TT4ILYC DMRSGC5 MN Bacterial Dihydropteroate synthetase (Bact folP) DMRSGC5 MT DTT DMRSGC5 MA Inhibitor DMRSGC5 RN Structural studies of pterin-based inhibitors of dihydropteroate synthase. J Med Chem. 2010 Jan 14;53(1):166-77. DMRSGC5 RU https://pubmed.ncbi.nlm.nih.gov/19899766 DMEMANH DI DMEMANH DMEMANH DN 2-Amino-benzenesulfonamide DMEMANH MI TTUNARX DMEMANH MN Carbonic anhydrase (CA) DMEMANH MT DTT DMEMANH MA Inhibitor DMEMANH RN Cloning, expression, post-translational modifications and inhibition studies on the latest mammalian carbonic anhydrase isoform, CA XV. J Med Chem. 2009 Feb 12;52(3):646-54. DMEMANH RU https://pubmed.ncbi.nlm.nih.gov/19193158 DMEMANH DI DMEMANH DMEMANH DN 2-Amino-benzenesulfonamide DMEMANH MI TTANPDJ DMEMANH MN Carbonic anhydrase II (CA-II) DMEMANH MT DTT DMEMANH MA Inhibitor DMEMANH RN Carbonic anhydrase inhibitors. Characterization and inhibition studies of the most active beta-carbonic anhydrase from Mycobacterium tuberculosis, ... Bioorg Med Chem Lett. 2009 Dec 1;19(23):6649-54. DMEMANH RU https://pubmed.ncbi.nlm.nih.gov/19846301 DMEMANH DI DMEMANH DMEMANH DN 2-Amino-benzenesulfonamide DMEMANH MI TT2LVK8 DMEMANH MN Carbonic anhydrase IX (CA-IX) DMEMANH MT DTT DMEMANH MA Inhibitor DMEMANH RN Cloning, expression, post-translational modifications and inhibition studies on the latest mammalian carbonic anhydrase isoform, CA XV. J Med Chem. 2009 Feb 12;52(3):646-54. DMEMANH RU https://pubmed.ncbi.nlm.nih.gov/19193158 DMEMANH DI DMEMANH DMEMANH DN 2-Amino-benzenesulfonamide DMEMANH MI TTCFSPE DMEMANH MN Carbonic anhydrase VI (CA-VI) DMEMANH MT DTT DMEMANH MA Inhibitor DMEMANH RN Cloning, expression, post-translational modifications and inhibition studies on the latest mammalian carbonic anhydrase isoform, CA XV. J Med Chem. 2009 Feb 12;52(3):646-54. DMEMANH RU https://pubmed.ncbi.nlm.nih.gov/19193158 DMEMANH DI DMEMANH DMEMANH DN 2-Amino-benzenesulfonamide DMEMANH MI TTSYM0R DMEMANH MN Carbonic anhydrase XII (CA-XII) DMEMANH MT DTT DMEMANH MA Inhibitor DMEMANH RN Carbonic anhydrase inhibitors. Inhibition of the transmembrane isozyme XII with sulfonamides-a new target for the design of antitumor and antiglauc... Bioorg Med Chem Lett. 2005 Feb 15;15(4):963-9. DMEMANH RU https://pubmed.ncbi.nlm.nih.gov/15686894 DMEMANH DI DMEMANH DMEMANH DN 2-Amino-benzenesulfonamide DMEMANH MI TTEYTKG DMEMANH MN Carbonic anhydrase XIV (CA-XIV) DMEMANH MT DTT DMEMANH MA Inhibitor DMEMANH RN Carbonic anhydrase inhibitors: inhibition of the transmembrane isozyme XIV with sulfonamides. Bioorg Med Chem Lett. 2005 Sep 1;15(17):3828-33. DMEMANH RU https://pubmed.ncbi.nlm.nih.gov/16039848 DM2OE1W DI DM2OE1W DM2OE1W DN 2-Aminoethanimidic Acid DM2OE1W MI TTF2LRI DM2OE1W MN Cathepsin B (CTSB) DM2OE1W MT DTT DM2OE1W MA Inhibitor DM2OE1W RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DM2OE1W RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMUJC2E DI DMUJC2E DMUJC2E DN 2'-aminoimidazolylmethyluracils DMUJC2E MI TTO0IB8 DMUJC2E MN Thymidine phosphorylase (TYMP) DMUJC2E MT DTT DMUJC2E MA Inhibitor DMUJC2E RN Potential tumor-selective nitroimidazolylmethyluracil prodrug derivatives: inhibitors of the angiogenic enzyme thymidine phosphorylase. J Med Chem. 2003 Jan 16;46(2):207-9. DMUJC2E RU https://pubmed.ncbi.nlm.nih.gov/12519058 DMCUSH1 DI DMCUSH1 DMCUSH1 DN 2-Amino-indan-5-sulfonic acid DMCUSH1 MI TTUNARX DMCUSH1 MN Carbonic anhydrase (CA) DMCUSH1 MT DTT DMCUSH1 MA Inhibitor DMCUSH1 RN Indanesulfonamides as carbonic anhydrase inhibitors and anticonvulsant agents: structure-activity relationship and pharmacological evaluation. Eur J Med Chem. 2008 Dec;43(12):2853-60. DMCUSH1 RU https://pubmed.ncbi.nlm.nih.gov/18406497 DMCUSH1 DI DMCUSH1 DMCUSH1 DN 2-Amino-indan-5-sulfonic acid DMCUSH1 MI TTHQPL7 DMCUSH1 MN Carbonic anhydrase I (CA-I) DMCUSH1 MT DTT DMCUSH1 MA Inhibitor DMCUSH1 RN Carbonic anhydrase inhibitors. Design of anticonvulsant sulfonamides incorporating indane moieties. Bioorg Med Chem Lett. 2004 Dec 6;14(23):5781-6. DMCUSH1 RU https://pubmed.ncbi.nlm.nih.gov/15501040 DMCUSH1 DI DMCUSH1 DMCUSH1 DN 2-Amino-indan-5-sulfonic acid DMCUSH1 MI TTANPDJ DMCUSH1 MN Carbonic anhydrase II (CA-II) DMCUSH1 MT DTT DMCUSH1 MA Inhibitor DMCUSH1 RN Carbonic anhydrase inhibitors. Design of anticonvulsant sulfonamides incorporating indane moieties. Bioorg Med Chem Lett. 2004 Dec 6;14(23):5781-6. DMCUSH1 RU https://pubmed.ncbi.nlm.nih.gov/15501040 DMCUSH1 DI DMCUSH1 DMCUSH1 DN 2-Amino-indan-5-sulfonic acid DMCUSH1 MI TTSYM0R DMCUSH1 MN Carbonic anhydrase XII (CA-XII) DMCUSH1 MT DTT DMCUSH1 MA Inhibitor DMCUSH1 RN Indanesulfonamides as carbonic anhydrase inhibitors and anticonvulsant agents: structure-activity relationship and pharmacological evaluation. Eur J Med Chem. 2008 Dec;43(12):2853-60. DMCUSH1 RU https://pubmed.ncbi.nlm.nih.gov/18406497 DMCUSH1 DI DMCUSH1 DMCUSH1 DN 2-Amino-indan-5-sulfonic acid DMCUSH1 MI TTEYTKG DMCUSH1 MN Carbonic anhydrase XIV (CA-XIV) DMCUSH1 MT DTT DMCUSH1 MA Inhibitor DMCUSH1 RN Indanesulfonamides as carbonic anhydrase inhibitors and anticonvulsant agents: structure-activity relationship and pharmacological evaluation. Eur J Med Chem. 2008 Dec;43(12):2853-60. DMCUSH1 RU https://pubmed.ncbi.nlm.nih.gov/18406497 DMCJUWK DI DMCJUWK DMCJUWK DN 2-Aminomethyl-5-(p-bromophenyl)tetrahydrofuran DMCJUWK MI TTVBI8W DMCJUWK MN Dopamine transporter (DAT) DMCJUWK MT DTT DMCJUWK MA Inhibitor DMCJUWK RN 2,5-Disubstituted tetrahydrofurans as selective serotonin re-uptake inhibitors. Bioorg Med Chem. 2009 Mar 1;17(5):2047-68. DMCJUWK RU https://pubmed.ncbi.nlm.nih.gov/19201198 DMCJUWK DI DMCJUWK DMCJUWK DN 2-Aminomethyl-5-(p-bromophenyl)tetrahydrofuran DMCJUWK MI TTAWNKZ DMCJUWK MN Norepinephrine transporter (NET) DMCJUWK MT DTT DMCJUWK MA Inhibitor DMCJUWK RN 2,5-Disubstituted tetrahydrofurans as selective serotonin re-uptake inhibitors. Bioorg Med Chem. 2009 Mar 1;17(5):2047-68. DMCJUWK RU https://pubmed.ncbi.nlm.nih.gov/19201198 DMCJUWK DI DMCJUWK DMCJUWK DN 2-Aminomethyl-5-(p-bromophenyl)tetrahydrofuran DMCJUWK MI TT3ROYC DMCJUWK MN Serotonin transporter (SERT) DMCJUWK MT DTT DMCJUWK MA Inhibitor DMCJUWK RN 2,5-Disubstituted tetrahydrofurans as selective serotonin re-uptake inhibitors. Bioorg Med Chem. 2009 Mar 1;17(5):2047-68. DMCJUWK RU https://pubmed.ncbi.nlm.nih.gov/19201198 DM3OTZY DI DM3OTZY DM3OTZY DN 2-Aminomethyl-5-(p-chlorophenyl)tetrahydrofuran DM3OTZY MI TTVBI8W DM3OTZY MN Dopamine transporter (DAT) DM3OTZY MT DTT DM3OTZY MA Inhibitor DM3OTZY RN 2,5-Disubstituted tetrahydrofurans as selective serotonin re-uptake inhibitors. Bioorg Med Chem. 2009 Mar 1;17(5):2047-68. DM3OTZY RU https://pubmed.ncbi.nlm.nih.gov/19201198 DM3OTZY DI DM3OTZY DM3OTZY DN 2-Aminomethyl-5-(p-chlorophenyl)tetrahydrofuran DM3OTZY MI TTAWNKZ DM3OTZY MN Norepinephrine transporter (NET) DM3OTZY MT DTT DM3OTZY MA Inhibitor DM3OTZY RN 2,5-Disubstituted tetrahydrofurans as selective serotonin re-uptake inhibitors. Bioorg Med Chem. 2009 Mar 1;17(5):2047-68. DM3OTZY RU https://pubmed.ncbi.nlm.nih.gov/19201198 DM3OTZY DI DM3OTZY DM3OTZY DN 2-Aminomethyl-5-(p-chlorophenyl)tetrahydrofuran DM3OTZY MI TT3ROYC DM3OTZY MN Serotonin transporter (SERT) DM3OTZY MT DTT DM3OTZY MA Inhibitor DM3OTZY RN 2,5-Disubstituted tetrahydrofurans as selective serotonin re-uptake inhibitors. Bioorg Med Chem. 2009 Mar 1;17(5):2047-68. DM3OTZY RU https://pubmed.ncbi.nlm.nih.gov/19201198 DM413ZB DI DM413ZB DM413ZB DN 2-Aminomethyl-5-(phenyl)tetrahydrofuran DM413ZB MI TTVBI8W DM413ZB MN Dopamine transporter (DAT) DM413ZB MT DTT DM413ZB MA Inhibitor DM413ZB RN 2,5-Disubstituted tetrahydrofurans as selective serotonin re-uptake inhibitors. Bioorg Med Chem. 2009 Mar 1;17(5):2047-68. DM413ZB RU https://pubmed.ncbi.nlm.nih.gov/19201198 DM413ZB DI DM413ZB DM413ZB DN 2-Aminomethyl-5-(phenyl)tetrahydrofuran DM413ZB MI TTAWNKZ DM413ZB MN Norepinephrine transporter (NET) DM413ZB MT DTT DM413ZB MA Inhibitor DM413ZB RN 2,5-Disubstituted tetrahydrofurans as selective serotonin re-uptake inhibitors. Bioorg Med Chem. 2009 Mar 1;17(5):2047-68. DM413ZB RU https://pubmed.ncbi.nlm.nih.gov/19201198 DM413ZB DI DM413ZB DM413ZB DN 2-Aminomethyl-5-(phenyl)tetrahydrofuran DM413ZB MI TT3ROYC DM413ZB MN Serotonin transporter (SERT) DM413ZB MT DTT DM413ZB MA Inhibitor DM413ZB RN 2,5-Disubstituted tetrahydrofurans as selective serotonin re-uptake inhibitors. Bioorg Med Chem. 2009 Mar 1;17(5):2047-68. DM413ZB RU https://pubmed.ncbi.nlm.nih.gov/19201198 DMDG8FL DI DMDG8FL DMDG8FL DN 2-Aminomethyl-5-(p-methoxyphenyl)tetrahydrofuran DMDG8FL MI TTVBI8W DMDG8FL MN Dopamine transporter (DAT) DMDG8FL MT DTT DMDG8FL MA Inhibitor DMDG8FL RN 2,5-Disubstituted tetrahydrofurans as selective serotonin re-uptake inhibitors. Bioorg Med Chem. 2009 Mar 1;17(5):2047-68. DMDG8FL RU https://pubmed.ncbi.nlm.nih.gov/19201198 DMDG8FL DI DMDG8FL DMDG8FL DN 2-Aminomethyl-5-(p-methoxyphenyl)tetrahydrofuran DMDG8FL MI TTAWNKZ DMDG8FL MN Norepinephrine transporter (NET) DMDG8FL MT DTT DMDG8FL MA Inhibitor DMDG8FL RN 2,5-Disubstituted tetrahydrofurans as selective serotonin re-uptake inhibitors. Bioorg Med Chem. 2009 Mar 1;17(5):2047-68. DMDG8FL RU https://pubmed.ncbi.nlm.nih.gov/19201198 DMDG8FL DI DMDG8FL DMDG8FL DN 2-Aminomethyl-5-(p-methoxyphenyl)tetrahydrofuran DMDG8FL MI TT3ROYC DMDG8FL MN Serotonin transporter (SERT) DMDG8FL MT DTT DMDG8FL MA Inhibitor DMDG8FL RN 2,5-Disubstituted tetrahydrofurans as selective serotonin re-uptake inhibitors. Bioorg Med Chem. 2009 Mar 1;17(5):2047-68. DMDG8FL RU https://pubmed.ncbi.nlm.nih.gov/19201198 DME4P7K DI DME4P7K DME4P7K DN 2-Aminomethyl-5-(p-t-butylphenyl)tetrahydrofuran DME4P7K MI TTVBI8W DME4P7K MN Dopamine transporter (DAT) DME4P7K MT DTT DME4P7K MA Inhibitor DME4P7K RN 2,5-Disubstituted tetrahydrofurans as selective serotonin re-uptake inhibitors. Bioorg Med Chem. 2009 Mar 1;17(5):2047-68. DME4P7K RU https://pubmed.ncbi.nlm.nih.gov/19201198 DME4P7K DI DME4P7K DME4P7K DN 2-Aminomethyl-5-(p-t-butylphenyl)tetrahydrofuran DME4P7K MI TTAWNKZ DME4P7K MN Norepinephrine transporter (NET) DME4P7K MT DTT DME4P7K MA Inhibitor DME4P7K RN 2,5-Disubstituted tetrahydrofurans as selective serotonin re-uptake inhibitors. Bioorg Med Chem. 2009 Mar 1;17(5):2047-68. DME4P7K RU https://pubmed.ncbi.nlm.nih.gov/19201198 DME4P7K DI DME4P7K DME4P7K DN 2-Aminomethyl-5-(p-t-butylphenyl)tetrahydrofuran DME4P7K MI TT3ROYC DME4P7K MN Serotonin transporter (SERT) DME4P7K MT DTT DME4P7K MA Inhibitor DME4P7K RN 2,5-Disubstituted tetrahydrofurans as selective serotonin re-uptake inhibitors. Bioorg Med Chem. 2009 Mar 1;17(5):2047-68. DME4P7K RU https://pubmed.ncbi.nlm.nih.gov/19201198 DMAN8EH DI DMAN8EH DMAN8EH DN 2-Aminomethyl-pyrrolidine-3,4-diol DMAN8EH MI TTXWASR DMAN8EH MN Intestinal maltase-glucoamylase (MGAM) DMAN8EH MT DTT DMAN8EH MA Inhibitor DMAN8EH RN Derivatives of (2R,3R,4S)-2-aminomethylpyrrolidine-3,4-diol are selective alpha-mannosidase inhibitors. Bioorg Med Chem Lett. 2001 Sep 17;11(18):2489-93. DMAN8EH RU https://pubmed.ncbi.nlm.nih.gov/11549453 DMESFTW DI DMESFTW DMESFTW DN 2-amino-N-(quinolin-8-yl)benzenesulfonamide DMESFTW MI TTSXVID DMESFTW MN Nuclear factor NF-kappa-B (NFKB) DMESFTW MT DTT DMESFTW MA Inhibitor DMESFTW RN Identification of N-(quinolin-8-yl)benzenesulfonamides as agents capable of down-regulating NFkappaB activity within two separate high-throughput s... Bioorg Med Chem Lett. 2008 Jan 1;18(1):329-35. DMESFTW RU https://pubmed.ncbi.nlm.nih.gov/18024113 DM3YI9P DI DM3YI9P DM3YI9P DN 2-Amino-N,3,3-Trimethylbutanamide DM3YI9P MI TT6X50U DM3YI9P MN Matrix metalloproteinase-9 (MMP-9) DM3YI9P MT DTT DM3YI9P MA Inhibitor DM3YI9P RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DM3YI9P RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMRY06D DI DMRY06D DMRY06D DN 2-Amino-N-[4-(phenylmethoxy)phenyl]-acetamide DMRY06D MI TTXZEAJ DMRY06D MN Leukotriene A-4 hydrolase (LTA4H) DMRY06D MT DTT DMRY06D MA Inhibitor DMRY06D RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DMRY06D RU https://pubmed.ncbi.nlm.nih.gov/10592235 DMQ30UY DI DMQ30UY DMQ30UY DN 2-amino-N1-benzyl-N3-hydroxymalonamide DMQ30UY MI TTPHMWB DMQ30UY MN Aminopeptidase N (ANPEP) DMQ30UY MT DTT DMQ30UY MA Inhibitor DMQ30UY RN Novel selective inhibitors of the zinc plasmodial aminopeptidase PfA-M1 as potential antimalarial agents. J Med Chem. 2007 Mar 22;50(6):1322-34. DMQ30UY RU https://pubmed.ncbi.nlm.nih.gov/17326615 DM320RW DI DM320RW DM320RW DN 2-amino-N-benzyl-6-phenyl-9H-purine-9-carboxamide DM320RW MI TTK25J1 DM320RW MN Adenosine A1 receptor (ADORA1) DM320RW MT DTT DM320RW MA Inhibitor DM320RW RN Antagonists of the human adenosine A2A receptor. Part 3: Design and synthesis of pyrazolo[3,4-d]pyrimidines, pyrrolo[2,3-d]pyrimidines and 6-arylpu... Bioorg Med Chem Lett. 2008 May 1;18(9):2924-9. DM320RW RU https://pubmed.ncbi.nlm.nih.gov/18411049 DM320RW DI DM320RW DM320RW DN 2-amino-N-benzyl-6-phenyl-9H-purine-9-carboxamide DM320RW MI TTM2AOE DM320RW MN Adenosine A2a receptor (ADORA2A) DM320RW MT DTT DM320RW MA Inhibitor DM320RW RN Antagonists of the human adenosine A2A receptor. Part 3: Design and synthesis of pyrazolo[3,4-d]pyrimidines, pyrrolo[2,3-d]pyrimidines and 6-arylpu... Bioorg Med Chem Lett. 2008 May 1;18(9):2924-9. DM320RW RU https://pubmed.ncbi.nlm.nih.gov/18411049 DMBVGAO DI DMBVGAO DMBVGAO DN 2-aminophenoxazine-3-one DMBVGAO MI TTF0RCZ DMBVGAO MN Apoptosis mediating surface antigen FAS (FAS) DMBVGAO MT DTT DMBVGAO MA Activator DMBVGAO RN Apoptosis as a mechanism for the treatment of adult T cell leukemia: promising drugs from benchside to bedside. Drug Discov Today. 2020 Jul;25(7):1189-1197. DMBVGAO RU https://pubmed.ncbi.nlm.nih.gov/32389641 DMBVGAO DI DMBVGAO DMBVGAO DN 2-aminophenoxazine-3-one DMBVGAO MI TTZY5KP DMBVGAO MN Caspase (CASP) DMBVGAO MT DTT DMBVGAO MA Activator DMBVGAO RN Apoptosis as a mechanism for the treatment of adult T cell leukemia: promising drugs from benchside to bedside. Drug Discov Today. 2020 Jul;25(7):1189-1197. DMBVGAO RU https://pubmed.ncbi.nlm.nih.gov/32389641 DMQIC3L DI DMQIC3L DMQIC3L DN 2-aminopyridine DMQIC3L MI TTZUFI5 DMQIC3L MN Nitric-oxide synthase brain (NOS1) DMQIC3L MT DTT DMQIC3L MA Inhibitor DMQIC3L RN L337H mutant of rat neuronal nitric oxide synthase resembles human neuronal nitric oxide synthase toward inhibitors. J Med Chem. 2009 Jul 23;52(14):4533-7. DMQIC3L RU https://pubmed.ncbi.nlm.nih.gov/19537690 DMJW4CS DI DMJW4CS DMJW4CS DN 2-aminoquinazoline-4-carboxy-(4-bromophenyl)amide DMJW4CS MI TTJFY5U DMJW4CS MN Adenosine A3 receptor (ADORA3) DMJW4CS MT DTT DMJW4CS MA Inhibitor DMJW4CS RN Scouting human A3 adenosine receptor antagonist binding mode using a molecular simplification approach: from triazoloquinoxaline to a pyrimidine sk... J Med Chem. 2007 Dec 27;50(26):6596-606. DMJW4CS RU https://pubmed.ncbi.nlm.nih.gov/18047262 DMQJYX7 DI DMQJYX7 DMQJYX7 DN 2-aminoquinazoline-4-carboxyanilide DMQJYX7 MI TTJFY5U DMQJYX7 MN Adenosine A3 receptor (ADORA3) DMQJYX7 MT DTT DMQJYX7 MA Inhibitor DMQJYX7 RN Scouting human A3 adenosine receptor antagonist binding mode using a molecular simplification approach: from triazoloquinoxaline to a pyrimidine sk... J Med Chem. 2007 Dec 27;50(26):6596-606. DMQJYX7 RU https://pubmed.ncbi.nlm.nih.gov/18047262 DME4856 DI DME4856 DME4856 DN 2-amino-quinoline-3-carboxylic acid amide DME4856 MI TTJ3E9X DME4856 MN Inhibitor of nuclear factor kappa-B kinase beta (IKKB) DME4856 MT DTT DME4856 MA Inhibitor DME4856 RN Evolution of the thienopyridine class of inhibitors of IkappaB kinase-beta: part I: hit-to-lead strategies. J Med Chem. 2006 May 18;49(10):2898-908. DME4856 RU https://pubmed.ncbi.nlm.nih.gov/16686533 DM9YCAH DI DM9YCAH DM9YCAH DN 2-Aminothiazoline DM9YCAH MI TTZUFI5 DM9YCAH MN Nitric-oxide synthase brain (NOS1) DM9YCAH MT DTT DM9YCAH MA Inhibitor DM9YCAH RN Evaluation of pyrrolidin-2-imines and 1,3-thiazolidin-2-imines as inhibitors of nitric oxide synthase. Bioorg Med Chem Lett. 2004 Sep 6;14(17):4539-44. DM9YCAH RU https://pubmed.ncbi.nlm.nih.gov/15357988 DM9YCAH DI DM9YCAH DM9YCAH DN 2-Aminothiazoline DM9YCAH MI TTCM4B3 DM9YCAH MN Nitric-oxide synthase endothelial (NOS3) DM9YCAH MT DTT DM9YCAH MA Inhibitor DM9YCAH RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DM9YCAH RU https://pubmed.ncbi.nlm.nih.gov/17139284 DM9YCAH DI DM9YCAH DM9YCAH DN 2-Aminothiazoline DM9YCAH MI TTF10I9 DM9YCAH MN Nitric-oxide synthase inducible (NOS2) DM9YCAH MT DTT DM9YCAH MA Inhibitor DM9YCAH RN Evaluation of pyrrolidin-2-imines and 1,3-thiazolidin-2-imines as inhibitors of nitric oxide synthase. Bioorg Med Chem Lett. 2004 Sep 6;14(17):4539-44. DM9YCAH RU https://pubmed.ncbi.nlm.nih.gov/15357988 DMO792L DI DMO792L DMO792L DN 2-amino-uridine-5'-monophosphate DMO792L MI TT24DGP DMO792L MN P2Y purinoceptor 4 (P2RY4) DMO792L MT DTT DMO792L MA Agonist DMO792L RN Structural modifications of UMP, UDP, and UTP leading to subtype-selective agonists for P2Y2, P2Y4, and P2Y6 receptors. J Med Chem. 2011 Apr 28;54(8):2878-90. DMO792L RU https://pubmed.ncbi.nlm.nih.gov/21417463 DMFNEZW DI DMFNEZW DMFNEZW DN 2-ANILINO-6-CYCLOHEXYLMETHOXYPURINE DMFNEZW MI TT7HF4W DMFNEZW MN Cyclin-dependent kinase 2 (CDK2) DMFNEZW MT DTT DMFNEZW MA Inhibitor DMFNEZW RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DMFNEZW RU https://pubmed.ncbi.nlm.nih.gov/10592235 DM9AKVR DI DM9AKVR DM9AKVR DN 2-APB DM9AKVR MI TTEBMN7 DM9AKVR MN Long transient receptor potential channel 2 (TRPM2) DM9AKVR MT DTT DM9AKVR MA Blocker (channel blocker) DM9AKVR RN Inhibition of the transient receptor potential cation channel TRPM2 by 2-aminoethoxydiphenyl borate (2-APB). Br J Pharmacol. 2008 Mar;153(6):1324-30. DM9AKVR RU https://pubmed.ncbi.nlm.nih.gov/18204483 DM9AKVR DI DM9AKVR DM9AKVR DN 2-APB DM9AKVR MI TTO3TD8 DM9AKVR MN Long transient receptor potential channel 3 (TRPM3) DM9AKVR MT DTT DM9AKVR MA Inhibitor (gating inhibitor) DM9AKVR RN Block of TRPC5 channels by 2-aminoethoxydiphenyl borate: a differential, extracellular and voltage-dependent effect. Br J Pharmacol. 2005 Jun;145(4):405-14. DM9AKVR RU https://pubmed.ncbi.nlm.nih.gov/15806115 DM9AKVR DI DM9AKVR DM9AKVR DN 2-APB DM9AKVR MI TTV76RD DM9AKVR MN Long transient receptor potential channel 6 (TRPM6) DM9AKVR MT DTT DM9AKVR MA Activator DM9AKVR RN Functional characterization of homo- and heteromeric channel kinases TRPM6 and TRPM7. J Gen Physiol. 2006 May;127(5):525-37. DM9AKVR RU https://pubmed.ncbi.nlm.nih.gov/16636202 DM9AKVR DI DM9AKVR DM9AKVR DN 2-APB DM9AKVR MI TTFPVZO DM9AKVR MN Long transient receptor potential channel 7 (TRPM7) DM9AKVR MT DTT DM9AKVR MA Activator DM9AKVR RN LTRPC7 is a Mg.ATP-regulated divalent cation channel required for cell viability. Nature. 2001 May 31;411(6837):590-5. DM9AKVR RU https://pubmed.ncbi.nlm.nih.gov/11385574 DM9AKVR DI DM9AKVR DM9AKVR DN 2-APB DM9AKVR MI TTXDKTO DM9AKVR MN Long transient receptor potential channel 8 (TRPM8) DM9AKVR MT DTT DM9AKVR MA Blocker (channel blocker) DM9AKVR RN Effects of antagonists and heat on TRPM8 channel currents in dorsal root ganglion neuron activated by nociceptive cold stress and menthol. Neurochem Res. 2012 Feb;37(2):314-20. DM9AKVR RU https://pubmed.ncbi.nlm.nih.gov/21964764 DM9AKVR DI DM9AKVR DM9AKVR DN 2-APB DM9AKVR MI TTA76X0 DM9AKVR MN Short transient receptor potential channel 1 (TRPC1) DM9AKVR MT DTT DM9AKVR MA Blocker (channel blocker) DM9AKVR RN TRPC1 and TRPC5 form a novel cation channel in mammalian brain. Neuron. 2001 Mar;29(3):645-55. DM9AKVR RU https://pubmed.ncbi.nlm.nih.gov/11301024 DM9AKVR DI DM9AKVR DM9AKVR DN 2-APB DM9AKVR MI TTSJ9E7 DM9AKVR MN Short transient receptor potential channel 2 (TRPC2) DM9AKVR MT DTT DM9AKVR MA Blocker (channel blocker) DM9AKVR RN A diacylglycerol-gated cation channel in vomeronasal neuron dendrites is impaired in TRPC2 mutant mice: mechanism of pheromone transduction. Neuron. 2003 Oct 30;40(3):551-61. DM9AKVR RU https://pubmed.ncbi.nlm.nih.gov/14642279 DM9AKVR DI DM9AKVR DM9AKVR DN 2-APB DM9AKVR MI TTNVC34 DM9AKVR MN Short transient receptor potential channel 3 (TRPC3) DM9AKVR MT DTT DM9AKVR MA Blocker (channel blocker) DM9AKVR RN Mechanism of inhibition of TRPC cation channels by 2-aminoethoxydiphenylborane. Mol Pharmacol. 2005 Sep;68(3):758-62. DM9AKVR RU https://pubmed.ncbi.nlm.nih.gov/15933213 DM9AKVR DI DM9AKVR DM9AKVR DN 2-APB DM9AKVR MI TTX0H5W DM9AKVR MN Short transient receptor potential channel 4 (TRPC4) DM9AKVR MT DTT DM9AKVR MA Blocker (channel blocker) DM9AKVR RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 489). DM9AKVR RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=489 DM9AKVR DI DM9AKVR DM9AKVR DN 2-APB DM9AKVR MI TT32NQ1 DM9AKVR MN Short transient receptor potential channel 5 (TRPC5) DM9AKVR MT DTT DM9AKVR MA Blocker (channel blocker) DM9AKVR RN Block of TRPC5 channels by 2-aminoethoxydiphenyl borate: a differential, extracellular and voltage-dependent effect. Br J Pharmacol. 2005 Jun;145(4):405-14. DM9AKVR RU https://pubmed.ncbi.nlm.nih.gov/15806115 DM9AKVR DI DM9AKVR DM9AKVR DN 2-APB DM9AKVR MI TTRBT3W DM9AKVR MN Short transient receptor potential channel 6 (TRPC6) DM9AKVR MT DTT DM9AKVR MA Blocker (channel blocker) DM9AKVR RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 491). DM9AKVR RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=491 DM9AKVR DI DM9AKVR DM9AKVR DN 2-APB DM9AKVR MI TT06GRA DM9AKVR MN Short transient receptor potential channel 7 (TRPC7) DM9AKVR MT DTT DM9AKVR MA Blocker (channel blocker) DM9AKVR RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 492). DM9AKVR RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=492 DM9AKVR DI DM9AKVR DM9AKVR DN 2-APB DM9AKVR MI TTMI6F5 DM9AKVR MN Transient receptor potential cation channel V1 (TRPV1) DM9AKVR MT DTT DM9AKVR MA Activator DM9AKVR RN 2-aminoethoxydiphenyl borate is a common activator of TRPV1, TRPV2, and TRPV3. J Biol Chem. 2004 Aug 20;279(34):35741-8. DM9AKVR RU https://pubmed.ncbi.nlm.nih.gov/15194687 DM9AKVR DI DM9AKVR DM9AKVR DN 2-APB DM9AKVR MI TTBECWA DM9AKVR MN Transient receptor potential cation channel V2 (TRPV2) DM9AKVR MT DTT DM9AKVR MA Activator DM9AKVR RN Pharmacological characterization and molecular determinants of the activation of transient receptor potential V2 channel orthologs by 2-aminoethoxy... Mol Pharmacol. 2007 Nov;72(5):1258-68. DM9AKVR RU https://pubmed.ncbi.nlm.nih.gov/17673572 DM9AKVR DI DM9AKVR DM9AKVR DN 2-APB DM9AKVR MI TT946IA DM9AKVR MN Transient receptor potential cation channel V3 (TRPV3) DM9AKVR MT DTT DM9AKVR MA Activator DM9AKVR RN 2-aminoethoxydiphenyl borate activates and sensitizes the heat-gated ion channel TRPV3. J Neurosci. 2004 Jun 2;24(22):5177-82. DM9AKVR RU https://pubmed.ncbi.nlm.nih.gov/15175387 DM9AKVR DI DM9AKVR DM9AKVR DN 2-APB DM9AKVR MI TTBK14N DM9AKVR MN Transient receptor potential cation channel V6 (TRPV6) DM9AKVR MT DTT DM9AKVR MA Activator DM9AKVR RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 512). DM9AKVR RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=512 DMM0KOJ DI DMM0KOJ DMM0KOJ DN 2-arachidonoylglycerol DMM0KOJ MI TTDP1UC DMM0KOJ MN Fatty acid amide hydrolase (FAAH) DMM0KOJ MT DTT DMM0KOJ MA Inhibitor DMM0KOJ RN Conformationally constrained analogues of 2-arachidonoylglycerol. Bioorg Med Chem Lett. 2007 Nov 1;17(21):5959-63. DMM0KOJ RU https://pubmed.ncbi.nlm.nih.gov/17826996 DMICOL3 DI DMICOL3 DMICOL3 DN 2-arachidonoylglycerolphosphoinositol DMICOL3 MI TTNET8J DMICOL3 MN G-protein coupled receptor 55 (GPR55) DMICOL3 MT DTT DMICOL3 MA Agonist DMICOL3 RN 2-Arachidonoyl-sn-glycero-3-phosphoinositol: a possible natural ligand for GPR55. J Biochem. 2009 Jan;145(1):13-20. DMICOL3 RU https://pubmed.ncbi.nlm.nih.gov/18845565 DM2H8TV DI DM2H8TV DM2H8TV DN 2-arachidonyl glyceryl ether DM2H8TV MI TTNET8J DM2H8TV MN G-protein coupled receptor 55 (GPR55) DM2H8TV MT DTT DM2H8TV MA Agonist DM2H8TV RN The orphan receptor GPR55 is a novel cannabinoid receptor. Br J Pharmacol. 2007 Dec;152(7):1092-101. DM2H8TV RU https://pubmed.ncbi.nlm.nih.gov/17876302 DMBSDIV DI DMBSDIV DMBSDIV DN 2-azido-N6-methyl-9-(beta-D-ribofuranosyl)adenine DMBSDIV MI TTK25J1 DMBSDIV MN Adenosine A1 receptor (ADORA1) DMBSDIV MT DTT DMBSDIV MA Inhibitor DMBSDIV RN 2-triazole-substituted adenosines: a new class of selective A3 adenosine receptor agonists, partial agonists, and antagonists. J Med Chem. 2006 Dec 14;49(25):7373-83. DMBSDIV RU https://pubmed.ncbi.nlm.nih.gov/17149867 DMBSDIV DI DMBSDIV DMBSDIV DN 2-azido-N6-methyl-9-(beta-D-ribofuranosyl)adenine DMBSDIV MI TTJFY5U DMBSDIV MN Adenosine A3 receptor (ADORA3) DMBSDIV MT DTT DMBSDIV MA Inhibitor DMBSDIV RN 2-triazole-substituted adenosines: a new class of selective A3 adenosine receptor agonists, partial agonists, and antagonists. J Med Chem. 2006 Dec 14;49(25):7373-83. DMBSDIV RU https://pubmed.ncbi.nlm.nih.gov/17149867 DMXZ1HL DI DMXZ1HL DMXZ1HL DN 2-Benzhydryl-7-hydroxy-chromen-4-one DMXZ1HL MI TTFBNVI DMXZ1HL MN Aldose reductase (AKR1B1) DMXZ1HL MT DTT DMXZ1HL MA Inhibitor DMXZ1HL RN 1-Benzopyran-4-one antioxidants as aldose reductase inhibitors. J Med Chem. 1999 Jun 3;42(11):1881-93. DMXZ1HL RU https://pubmed.ncbi.nlm.nih.gov/10354396 DMQX9PD DI DMQX9PD DMQX9PD DN 2-Benzoxy-5-(2-methylquinolin-7-yl)benzonitrile DMQX9PD MI TTHS256 DMQX9PD MN Metabotropic glutamate receptor 5 (mGluR5) DMQX9PD MT DTT DMQX9PD MA Inhibitor DMQX9PD RN Structure-activity relationships in a novel series of 7-substituted-aryl quinolines and 5-substituted-aryl benzothiazoles at the metabotropic gluta... Bioorg Med Chem. 2010 May 1;18(9):3026-35. DMQX9PD RU https://pubmed.ncbi.nlm.nih.gov/20382541 DMO97FR DI DMO97FR DMO97FR DN 2-benzoyl-3-(3,4-dihydroxyphenyl)acrylonitrile DMO97FR MI TTGKNB4 DMO97FR MN Epidermal growth factor receptor (EGFR) DMO97FR MT DTT DMO97FR MA Inhibitor DMO97FR RN Protein-tyrosine kinase inhibition: mechanism-based discovery of antitumor agents. J Nat Prod. 1992 Nov;55(11):1529-60. DMO97FR RU https://pubmed.ncbi.nlm.nih.gov/1479375 DMGEFQP DI DMGEFQP DMGEFQP DN 2-benzoylaminoquinazoline-4-carboxyanilide DMGEFQP MI TTJFY5U DMGEFQP MN Adenosine A3 receptor (ADORA3) DMGEFQP MT DTT DMGEFQP MA Inhibitor DMGEFQP RN Scouting human A3 adenosine receptor antagonist binding mode using a molecular simplification approach: from triazoloquinoxaline to a pyrimidine sk... J Med Chem. 2007 Dec 27;50(26):6596-606. DMGEFQP RU https://pubmed.ncbi.nlm.nih.gov/18047262 DM1CB5J DI DM1CB5J DM1CB5J DN 2-Benzyl-1,2-dihydro-indazol-3-one DM1CB5J MI TT2J34L DM1CB5J MN Arachidonate 5-lipoxygenase (5-LOX) DM1CB5J MT DTT DM1CB5J MA Inhibitor DM1CB5J RN Indazolinones, a new series of redox-active 5-lipoxygenase inhibitors with built-in selectivity and oral activity. J Med Chem. 1991 Mar;34(3):1028-36. DM1CB5J RU https://pubmed.ncbi.nlm.nih.gov/1848292 DM1CB5J DI DM1CB5J DM1CB5J DN 2-Benzyl-1,2-dihydro-indazol-3-one DM1CB5J MI TT8NGED DM1CB5J MN Prostaglandin G/H synthase 1 (COX-1) DM1CB5J MT DTT DM1CB5J MA Inhibitor DM1CB5J RN Indazolinones, a new series of redox-active 5-lipoxygenase inhibitors with built-in selectivity and oral activity. J Med Chem. 1991 Mar;34(3):1028-36. DM1CB5J RU https://pubmed.ncbi.nlm.nih.gov/1848292 DM1CB5J DI DM1CB5J DM1CB5J DN 2-Benzyl-1,2-dihydro-indazol-3-one DM1CB5J MI TTVKILB DM1CB5J MN Prostaglandin G/H synthase 2 (COX-2) DM1CB5J MT DTT DM1CB5J MA Inhibitor DM1CB5J RN Indazolinones, a new series of redox-active 5-lipoxygenase inhibitors with built-in selectivity and oral activity. J Med Chem. 1991 Mar;34(3):1028-36. DM1CB5J RU https://pubmed.ncbi.nlm.nih.gov/1848292 DMV7IWE DI DMV7IWE DMV7IWE DN 2-Benzyl-1-hydroxy-3H-benzo[f]chromen-3-one DMV7IWE MI TT8XK6L DMV7IWE MN Quinone reductase 1 (NQO1) DMV7IWE MT DTT DMV7IWE MA Inhibitor DMV7IWE RN Synthesis and biological evaluation of coumarin-based inhibitors of NAD(P)H: quinone oxidoreductase-1 (NQO1). J Med Chem. 2009 Nov 26;52(22):7142-56. DMV7IWE RU https://pubmed.ncbi.nlm.nih.gov/19877692 DMPYB93 DI DMPYB93 DMPYB93 DN 2-Benzyl-2H-indazole-7-carboxamide DMPYB93 MI TTVDSZ0 DMPYB93 MN Poly [ADP-ribose] polymerase 1 (PARP1) DMPYB93 MT DTT DMPYB93 MA Inhibitor DMPYB93 RN Discovery of 2-{4-[(3S)-piperidin-3-yl]phenyl}-2H-indazole-7-carboxamide (MK-4827): a novel oral poly(ADP-ribose)polymerase (PARP) inhibitor effica... J Med Chem. 2009 Nov 26;52(22):7170-85. DMPYB93 RU https://pubmed.ncbi.nlm.nih.gov/19873981 DM6E04T DI DM6E04T DM6E04T DN 2-benzyl-2H-pyrazolo[3,4-c]quinolin-4(5H)-one DM6E04T MI TTJFY5U DM6E04T MN Adenosine A3 receptor (ADORA3) DM6E04T MT DTT DM6E04T MA Inhibitor DM6E04T RN New 2-arylpyrazolo[3,4-c]quinoline derivatives as potent and selective human A3 adenosine receptor antagonists. Synthesis, pharmacological evaluati... J Med Chem. 2007 Aug 23;50(17):4061-74. DM6E04T RU https://pubmed.ncbi.nlm.nih.gov/17665891 DMANTCY DI DMANTCY DMANTCY DN 2-Benzyl-3-phenyl-7-(trifluoromethyl)-2H-indazole DMANTCY MI TTECBXN DMANTCY MN Oxysterols receptor LXR-alpha (NR1H3) DMANTCY MT DTT DMANTCY MA Inhibitor DMANTCY RN Indazole-based liver X receptor (LXR) modulators with maintained atherosclerotic lesion reduction activity but diminished stimulation of hepatic tr... J Med Chem. 2008 Nov 27;51(22):7161-8. DMANTCY RU https://pubmed.ncbi.nlm.nih.gov/18973288 DMANTCY DI DMANTCY DMANTCY DN 2-Benzyl-3-phenyl-7-(trifluoromethyl)-2H-indazole DMANTCY MI TTXA6PH DMANTCY MN Oxysterols receptor LXR-beta (NR1H2) DMANTCY MT DTT DMANTCY MA Inhibitor DMANTCY RN Indazole-based liver X receptor (LXR) modulators with maintained atherosclerotic lesion reduction activity but diminished stimulation of hepatic tr... J Med Chem. 2008 Nov 27;51(22):7161-8. DMANTCY RU https://pubmed.ncbi.nlm.nih.gov/18973288 DMH76SO DI DMH76SO DMH76SO DN 2-benzyl-4,5,6,7-tetrachloroisoindoline-1,3-dione DMH76SO MI TTECBXN DMH76SO MN Oxysterols receptor LXR-alpha (NR1H3) DMH76SO MT DTT DMH76SO MA Inhibitor DMH76SO RN Liver X receptor antagonists with a phthalimide skeleton derived from thalidomide-related glucosidase inhibitors. Bioorg Med Chem Lett. 2007 Jul 15;17(14):3957-61. DMH76SO RU https://pubmed.ncbi.nlm.nih.gov/17498949 DMH76SO DI DMH76SO DMH76SO DN 2-benzyl-4,5,6,7-tetrachloroisoindoline-1,3-dione DMH76SO MI TTXA6PH DMH76SO MN Oxysterols receptor LXR-beta (NR1H2) DMH76SO MT DTT DMH76SO MA Inhibitor DMH76SO RN Liver X receptor antagonists with a phthalimide skeleton derived from thalidomide-related glucosidase inhibitors. Bioorg Med Chem Lett. 2007 Jul 15;17(14):3957-61. DMH76SO RU https://pubmed.ncbi.nlm.nih.gov/17498949 DMYGKW5 DI DMYGKW5 DMYGKW5 DN 2-Benzyl-4-piperazin-1-yl-1H-benzimidazole DMYGKW5 MI TTJS8PY DMYGKW5 MN 5-HT 6 receptor (HTR6) DMYGKW5 MT DTT DMYGKW5 MA Inhibitor DMYGKW5 RN Benzimidazole derivatives as new serotonin 5-HT6 receptor antagonists. Molecular mechanisms of receptor inactivation. J Med Chem. 2010 Feb 11;53(3):1357-69. DMYGKW5 RU https://pubmed.ncbi.nlm.nih.gov/20078106 DM3I7EL DI DM3I7EL DM3I7EL DN 2-benzyl-5-mercaptopentanoic acid DM3I7EL MI TT9G4N0 DM3I7EL MN Glutamate carboxypeptidase II (GCPII) DM3I7EL MT DTT DM3I7EL MA Inhibitor DM3I7EL RN Structural optimization of thiol-based inhibitors of glutamate carboxypeptidase II by modification of the P1' side chain. J Med Chem. 2006 May 18;49(10):2876-85. DM3I7EL RU https://pubmed.ncbi.nlm.nih.gov/16686531 DMGWRID DI DMGWRID DMGWRID DN 2-Benzyl-6-methoxy-5-oxazol-5-yl-1H-indole DMGWRID MI TTTB4UP DMGWRID MN Inosine-5'-monophosphate dehydrogenase 2 (IMPDH2) DMGWRID MT DTT DMGWRID MA Inhibitor DMGWRID RN Novel indole-based inhibitors of IMPDH: introduction of hydrogen bond acceptors at indole C-3. Bioorg Med Chem Lett. 2003 Apr 7;13(7):1273-6. DMGWRID RU https://pubmed.ncbi.nlm.nih.gov/12657262 DMAX5TC DI DMAX5TC DMAX5TC DN 2-Benzyl-7-hydroxy-chromen-4-one DMAX5TC MI TTFBNVI DMAX5TC MN Aldose reductase (AKR1B1) DMAX5TC MT DTT DMAX5TC MA Inhibitor DMAX5TC RN 1-Benzopyran-4-one antioxidants as aldose reductase inhibitors. J Med Chem. 1999 Jun 3;42(11):1881-93. DMAX5TC RU https://pubmed.ncbi.nlm.nih.gov/10354396 DM6EMGJ DI DM6EMGJ DM6EMGJ DN 2-Benzylaminomethyl-3-hydroxymorphinan DM6EMGJ MI TTQW87Y DM6EMGJ MN Opioid receptor kappa (OPRK1) DM6EMGJ MT DTT DM6EMGJ MA Inhibitor DM6EMGJ RN Synthesis and opioid receptor binding affinities of 2-substituted and 3-aminomorphinans: ligands for mu, kappa, and delta opioid receptors. J Med Chem. 2010 Jan 14;53(1):402-18. DM6EMGJ RU https://pubmed.ncbi.nlm.nih.gov/19928862 DM6EMGJ DI DM6EMGJ DM6EMGJ DN 2-Benzylaminomethyl-3-hydroxymorphinan DM6EMGJ MI TTKWM86 DM6EMGJ MN Opioid receptor mu (MOP) DM6EMGJ MT DTT DM6EMGJ MA Inhibitor DM6EMGJ RN Synthesis and opioid receptor binding affinities of 2-substituted and 3-aminomorphinans: ligands for mu, kappa, and delta opioid receptors. J Med Chem. 2010 Jan 14;53(1):402-18. DM6EMGJ RU https://pubmed.ncbi.nlm.nih.gov/19928862 DMM48L6 DI DMM48L6 DMM48L6 DN 2-Benzylbenzo[f]chromen-3-one DMM48L6 MI TT6OEDT DMM48L6 MN Cannabinoid receptor 1 (CB1) DMM48L6 MT DTT DMM48L6 MA Inhibitor DMM48L6 RN Synthesis and pharmacological evaluation of coumarin derivatives as cannabinoid receptor antagonists and inverse agonists. Bioorg Med Chem. 2009 Apr 1;17(7):2842-51. DMM48L6 RU https://pubmed.ncbi.nlm.nih.gov/19278853 DME7SAV DI DME7SAV DME7SAV DN 2-benzylisoquinoline-1,3,4-trione DME7SAV MI TTPF2QI DME7SAV MN Caspase-3 (CASP3) DME7SAV MT DTT DME7SAV MA Inhibitor DME7SAV RN Design, synthesis, and biological evaluation of isoquinoline-1,3,4-trione derivatives as potent caspase-3 inhibitors. J Med Chem. 2006 Mar 9;49(5):1613-23. DME7SAV RU https://pubmed.ncbi.nlm.nih.gov/16509578 DMF5MGQ DI DMF5MGQ DMF5MGQ DN 2-benzyl-N1-hydroxy-N3-(3-phenylpropyl)malonamide DMF5MGQ MI TTPHMWB DMF5MGQ MN Aminopeptidase N (ANPEP) DMF5MGQ MT DTT DMF5MGQ MA Inhibitor DMF5MGQ RN Novel selective inhibitors of the zinc plasmodial aminopeptidase PfA-M1 as potential antimalarial agents. J Med Chem. 2007 Mar 22;50(6):1322-34. DMF5MGQ RU https://pubmed.ncbi.nlm.nih.gov/17326615 DMRVA94 DI DMRVA94 DMRVA94 DN 2-benzyl-N1-hydroxy-N3-(4-phenylbutyl)malonamide DMRVA94 MI TTPHMWB DMRVA94 MN Aminopeptidase N (ANPEP) DMRVA94 MT DTT DMRVA94 MA Inhibitor DMRVA94 RN Novel selective inhibitors of the zinc plasmodial aminopeptidase PfA-M1 as potential antimalarial agents. J Med Chem. 2007 Mar 22;50(6):1322-34. DMRVA94 RU https://pubmed.ncbi.nlm.nih.gov/17326615 DM2BPIN DI DM2BPIN DM2BPIN DN 2-benzyl-N1-hydroxy-N3-phenethylmalonamide DM2BPIN MI TTPHMWB DM2BPIN MN Aminopeptidase N (ANPEP) DM2BPIN MT DTT DM2BPIN MA Inhibitor DM2BPIN RN Novel selective inhibitors of the zinc plasmodial aminopeptidase PfA-M1 as potential antimalarial agents. J Med Chem. 2007 Mar 22;50(6):1322-34. DM2BPIN RU https://pubmed.ncbi.nlm.nih.gov/17326615 DMCLAXG DI DMCLAXG DMCLAXG DN 2-benzyloxy-7,8-dihydro-6H-quinolin-5-one DMCLAXG MI TTHS256 DMCLAXG MN Metabotropic glutamate receptor 5 (mGluR5) DMCLAXG MT DTT DMCLAXG MA Inhibitor DMCLAXG RN Positive and negative modulation of group I metabotropic glutamate receptors. J Med Chem. 2008 Feb 14;51(3):634-47. DMCLAXG RU https://pubmed.ncbi.nlm.nih.gov/18173231 DM6F0C4 DI DM6F0C4 DM6F0C4 DN 2-Benzylsulfanyl-6-chloro-pyrimidin-4-ylamine DM6F0C4 MI TT84ETX DM6F0C4 MN Human immunodeficiency virus Reverse transcriptase (HIV RT) DM6F0C4 MT DTT DM6F0C4 MA Inhibitor DM6F0C4 RN Pyrimidine thioethers: a novel class of HIV-1 reverse transcriptase inhibitors with activity against BHAP-resistant HIV. J Med Chem. 1998 Sep 24;41(20):3793-803. DM6F0C4 RU https://pubmed.ncbi.nlm.nih.gov/9748354 DMV4OY2 DI DMV4OY2 DMV4OY2 DN 2beta,3alpha-dihydroxyolean-12-en-28-oic acid DMV4OY2 MI TTZHY6R DMV4OY2 MN Glycogen phosphorylase muscle form (GP) DMV4OY2 MT DTT DMV4OY2 MA Inhibitor DMV4OY2 RN Practical synthesis of bredemolic acid, a natural inhibitor of glycogen phosphorylase. J Nat Prod. 2008 Nov;71(11):1877-80. DMV4OY2 RU https://pubmed.ncbi.nlm.nih.gov/18847277 DMU4Q8C DI DMU4Q8C DMU4Q8C DN 2beta,3alpha-dihydroxyurs-12-en-28-oic acid DMU4Q8C MI TTZHY6R DMU4Q8C MN Glycogen phosphorylase muscle form (GP) DMU4Q8C MT DTT DMU4Q8C MA Inhibitor DMU4Q8C RN Practical synthesis of bredemolic acid, a natural inhibitor of glycogen phosphorylase. J Nat Prod. 2008 Nov;71(11):1877-80. DMU4Q8C RU https://pubmed.ncbi.nlm.nih.gov/18847277 DMWZ4KN DI DMWZ4KN DMWZ4KN DN 2beta-methoxy-2-deethoxyphantomolin DMWZ4KN MI TTSXVID DMWZ4KN MN Nuclear factor NF-kappa-B (NFKB) DMWZ4KN MT DTT DMWZ4KN MA Inhibitor DMWZ4KN RN Development of a structural model for NF-kappaB inhibition of sesquiterpene lactones using self-organizing neural networks. J Med Chem. 2006 Apr 6;49(7):2241-52. DMWZ4KN RU https://pubmed.ncbi.nlm.nih.gov/16570920 DMFAW4R DI DMFAW4R DMFAW4R DN 2-BFi DMFAW4R MI TTWG9A4 DMFAW4R MN Adrenergic receptor alpha-2A (ADRA2A) DMFAW4R MT DTT DMFAW4R MA Inhibitor DMFAW4R RN Probes for imidazoline binding sites: synthesis and evaluation of a selective, irreversible I2 ligand. Bioorg Med Chem Lett. 2000 Mar 20;10(6):605-7. DMFAW4R RU https://pubmed.ncbi.nlm.nih.gov/10741563 DMFAW4R DI DMFAW4R DMFAW4R DN 2-BFi DMFAW4R MI TTWM4TY DMFAW4R MN Adrenergic receptor alpha-2B (ADRA2B) DMFAW4R MT DTT DMFAW4R MA Inhibitor DMFAW4R RN Probes for imidazoline binding sites: synthesis and evaluation of a selective, irreversible I2 ligand. Bioorg Med Chem Lett. 2000 Mar 20;10(6):605-7. DMFAW4R RU https://pubmed.ncbi.nlm.nih.gov/10741563 DMFAW4R DI DMFAW4R DMFAW4R DN 2-BFi DMFAW4R MI TT2NUT5 DMFAW4R MN Adrenergic receptor alpha-2C (ADRA2C) DMFAW4R MT DTT DMFAW4R MA Inhibitor DMFAW4R RN Probes for imidazoline binding sites: synthesis and evaluation of a selective, irreversible I2 ligand. Bioorg Med Chem Lett. 2000 Mar 20;10(6):605-7. DMFAW4R RU https://pubmed.ncbi.nlm.nih.gov/10741563 DMFAW4R DI DMFAW4R DMFAW4R DN 2-BFi DMFAW4R MI TT3WG5C DMFAW4R MN Monoamine oxidase type A (MAO-A) DMFAW4R MT DTT DMFAW4R MA Inhibitor DMFAW4R RN Probes for imidazoline binding sites: synthesis and evaluation of a selective, irreversible I2 ligand. Bioorg Med Chem Lett. 2000 Mar 20;10(6):605-7. DMFAW4R RU https://pubmed.ncbi.nlm.nih.gov/10741563 DMFAW4R DI DMFAW4R DMFAW4R DN 2-BFi DMFAW4R MI TTGP7BY DMFAW4R MN Monoamine oxidase type B (MAO-B) DMFAW4R MT DTT DMFAW4R MA Inhibitor DMFAW4R RN Ultrasound promoted synthesis of 2-imidazolines in water: a greener approach toward monoamine oxidase inhibitors. Bioorg Med Chem Lett. 2009 Jan 15;19(2):546-9. DMFAW4R RU https://pubmed.ncbi.nlm.nih.gov/19064321 DMHS3N6 DI DMHS3N6 DMHS3N6 DN 2-biphenyl-4-yl-1-phenothiazin-10-yl-ethanone DMHS3N6 MI TTEB0GD DMHS3N6 MN Cholinesterase (BCHE) DMHS3N6 MT DTT DMHS3N6 MA Inhibitor DMHS3N6 RN Selective reversible inhibition of human butyrylcholinesterase by aryl amide derivatives of phenothiazine. Bioorg Med Chem. 2007 Oct 1;15(19):6367-78. DMHS3N6 RU https://pubmed.ncbi.nlm.nih.gov/17681768 DML1W5Z DI DML1W5Z DML1W5Z DN 2-biphenyl-4-yl-6-morpholin-4-yl-pyran-4-one DML1W5Z MI TTK3PY9 DML1W5Z MN DNA-dependent protein kinase catalytic (PRKDC) DML1W5Z MT DTT DML1W5Z MA Inhibitor DML1W5Z RN Pyranone, thiopyranone, and pyridone inhibitors of phosphatidylinositol 3-kinase related kinases. Structure-activity relationships for DNA-dependen... J Med Chem. 2007 Apr 19;50(8):1958-72. DML1W5Z RU https://pubmed.ncbi.nlm.nih.gov/17371003 DMWOJ5N DI DMWOJ5N DMWOJ5N DN 2-Biphenyl-4-yl-N-hydroxy-N-methyl-acetamide DMWOJ5N MI TT2J34L DMWOJ5N MN Arachidonate 5-lipoxygenase (5-LOX) DMWOJ5N MT DTT DMWOJ5N MA Inhibitor DMWOJ5N RN Hydroxamic acid inhibitors of 5-lipoxygenase: quantitative structure-activity relationships. J Med Chem. 1990 Mar;33(3):992-8. DMWOJ5N RU https://pubmed.ncbi.nlm.nih.gov/2308149 DMCM01R DI DMCM01R DMCM01R DN 2-bromo-4-(3-fluorophenylethynyl)thiazole DMCM01R MI TTHS256 DMCM01R MN Metabotropic glutamate receptor 5 (mGluR5) DMCM01R MT DTT DMCM01R MA Inhibitor DMCM01R RN Synthesis and structure-activity relationships of 3-[(2-methyl-1,3-thiazol-4-yl)ethynyl]pyridine analogues as potent, noncompetitive metabotropic g... J Med Chem. 2006 Feb 9;49(3):1080-100. DMCM01R RU https://pubmed.ncbi.nlm.nih.gov/16451073 DMJ0368 DI DMJ0368 DMJ0368 DN 2-bromo-4-methylphenyl 2-nitrobenzoate DMJ0368 MI TTVTX4N DMJ0368 MN Bacterial Fatty acid synthetase I (Bact inhA) DMJ0368 MT DTT DMJ0368 MA Inhibitor DMJ0368 RN Discovery of potential new InhA direct inhibitors based on pharmacophore and 3D-QSAR analysis followed by in silico screening. Eur J Med Chem. 2009 Sep;44(9):3718-30. DMJ0368 RU https://pubmed.ncbi.nlm.nih.gov/19428156 DMIHJSA DI DMIHJSA DMIHJSA DN 2-Bromoacetyl Group DMIHJSA MI TT8NGED DMIHJSA MN Prostaglandin G/H synthase 1 (COX-1) DMIHJSA MT DTT DMIHJSA MA Inhibitor DMIHJSA RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMIHJSA RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMOYCWU DI DMOYCWU DMOYCWU DN 2-bromo-LSD DMOYCWU MI TTJS8PY DMOYCWU MN 5-HT 6 receptor (HTR6) DMOYCWU MT DTT DMOYCWU MA Antagonist DMOYCWU RN Cloning and expression of a novel serotonin receptor with high affinity for tricyclic psychotropic drugs. Mol Pharmacol. 1993 Mar;43(3):320-7. DMOYCWU RU https://pubmed.ncbi.nlm.nih.gov/7680751 DMOYCWU DI DMOYCWU DMOYCWU DN 2-bromo-LSD DMOYCWU MI TTO9X1H DMOYCWU MN 5-HT 7 receptor (HTR7) DMOYCWU MT DTT DMOYCWU MA Antagonist DMOYCWU RN Molecular cloning of a mammalian serotonin receptor that activates adenylate cyclase. Mol Pharmacol. 1993 Aug;44(2):229-36. DMOYCWU RU https://pubmed.ncbi.nlm.nih.gov/8394987 DMYCENM DI DMYCENM DMYCENM DN 2-Bromo-N-(2-morpholinoethyl)nicotinamide DMYCENM MI TT3WG5C DMYCENM MN Monoamine oxidase type A (MAO-A) DMYCENM MT DTT DMYCENM MA Inhibitor DMYCENM RN Design of novel nicotinamides as potent and selective monoamine oxidase a inhibitors. Bioorg Med Chem. 2010 Feb 15;18(4):1659-64. DMYCENM RU https://pubmed.ncbi.nlm.nih.gov/20117937 DMYCENM DI DMYCENM DMYCENM DN 2-Bromo-N-(2-morpholinoethyl)nicotinamide DMYCENM MI TTGP7BY DMYCENM MN Monoamine oxidase type B (MAO-B) DMYCENM MT DTT DMYCENM MA Inhibitor DMYCENM RN Design of novel nicotinamides as potent and selective monoamine oxidase a inhibitors. Bioorg Med Chem. 2010 Feb 15;18(4):1659-64. DMYCENM RU https://pubmed.ncbi.nlm.nih.gov/20117937 DM9NMIO DI DM9NMIO DM9NMIO DN 2-Bromo-N-(3-morpholinopropyl)nicotinamide DM9NMIO MI TTGP7BY DM9NMIO MN Monoamine oxidase type B (MAO-B) DM9NMIO MT DTT DM9NMIO MA Inhibitor DM9NMIO RN Design of novel nicotinamides as potent and selective monoamine oxidase a inhibitors. Bioorg Med Chem. 2010 Feb 15;18(4):1659-64. DM9NMIO RU https://pubmed.ncbi.nlm.nih.gov/20117937 DM6JDIY DI DM6JDIY DM6JDIY DN 2-bromophenol DM6JDIY MI TTU6BFZ DM6JDIY MN Candida Thymidylate synthase (Candi TMP1) DM6JDIY MT DTT DM6JDIY MA Inhibitor DM6JDIY RN DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Nucleic Acids Res. 2011 Jan;39(Database issue):D1035-41. DM6JDIY RU https://pubmed.ncbi.nlm.nih.gov/21059682 DMY7RM8 DI DMY7RM8 DMY7RM8 DN 2-Butyl-1(3)H-anthra[1,2-d]imidazole-6,11-dione DMY7RM8 MI TTQY2EJ DMY7RM8 MN TERT messenger RNA (TERT mRNA) DMY7RM8 MT DTT DMY7RM8 MA Inhibitor DMY7RM8 RN Synthesis, cytotoxicity and human telomerase inhibition activities of a series of 1,2-heteroannelated anthraquinones and anthra[1,2-d]imidazole-6,1... Bioorg Med Chem. 2009 Nov 1;17(21):7418-28. DMY7RM8 RU https://pubmed.ncbi.nlm.nih.gov/19804981 DML9MCU DI DML9MCU DML9MCU DN 2-butylamido-5-sulfonamidoindane DML9MCU MI TTHQPL7 DML9MCU MN Carbonic anhydrase I (CA-I) DML9MCU MT DTT DML9MCU MA Inhibitor DML9MCU RN Indanesulfonamides as carbonic anhydrase inhibitors. Toward structure-based design of selective inhibitors of the tumor-associated isozyme CA IX. J Med Chem. 2006 May 4;49(9):2743-9. DML9MCU RU https://pubmed.ncbi.nlm.nih.gov/16640335 DML9MCU DI DML9MCU DML9MCU DN 2-butylamido-5-sulfonamidoindane DML9MCU MI TTANPDJ DML9MCU MN Carbonic anhydrase II (CA-II) DML9MCU MT DTT DML9MCU MA Inhibitor DML9MCU RN Indanesulfonamides as carbonic anhydrase inhibitors. Toward structure-based design of selective inhibitors of the tumor-associated isozyme CA IX. J Med Chem. 2006 May 4;49(9):2743-9. DML9MCU RU https://pubmed.ncbi.nlm.nih.gov/16640335 DML9MCU DI DML9MCU DML9MCU DN 2-butylamido-5-sulfonamidoindane DML9MCU MI TT2LVK8 DML9MCU MN Carbonic anhydrase IX (CA-IX) DML9MCU MT DTT DML9MCU MA Inhibitor DML9MCU RN Indanesulfonamides as carbonic anhydrase inhibitors. Toward structure-based design of selective inhibitors of the tumor-associated isozyme CA IX. J Med Chem. 2006 May 4;49(9):2743-9. DML9MCU RU https://pubmed.ncbi.nlm.nih.gov/16640335 DMG5SAQ DI DMG5SAQ DMG5SAQ DN 2-chloro-1-(5-(pyridin-2-yl)oxazol-2-yl)ethanone DMG5SAQ MI TTDP1UC DMG5SAQ MN Fatty acid amide hydrolase (FAAH) DMG5SAQ MT DTT DMG5SAQ MA Inhibitor DMG5SAQ RN Structure-activity relationships of alpha-ketooxazole inhibitors of fatty acid amide hydrolase. J Med Chem. 2007 Jul 12;50(14):3359-68. DMG5SAQ RU https://pubmed.ncbi.nlm.nih.gov/17559203 DMD3ZNP DI DMD3ZNP DMD3ZNP DN 2-chloro-2'-C-methyl-tecadenoson DMD3ZNP MI TTK25J1 DMD3ZNP MN Adenosine A1 receptor (ADORA1) DMD3ZNP MT DTT DMD3ZNP MA Inhibitor DMD3ZNP RN 5'-Carbamoyl derivatives of 2'-C-methyl-purine nucleosides as selective A1 adenosine receptor agonists: affinity, efficacy, and selectivity for A1 ... Bioorg Med Chem. 2008 Jan 1;16(1):336-53. DMD3ZNP RU https://pubmed.ncbi.nlm.nih.gov/17933541 DMD3ZNP DI DMD3ZNP DMD3ZNP DN 2-chloro-2'-C-methyl-tecadenoson DMD3ZNP MI TTNE7KG DMD3ZNP MN Adenosine A2b receptor (ADORA2B) DMD3ZNP MT DTT DMD3ZNP MA Inhibitor DMD3ZNP RN 5'-Carbamoyl derivatives of 2'-C-methyl-purine nucleosides as selective A1 adenosine receptor agonists: affinity, efficacy, and selectivity for A1 ... Bioorg Med Chem. 2008 Jan 1;16(1):336-53. DMD3ZNP RU https://pubmed.ncbi.nlm.nih.gov/17933541 DMD3ZNP DI DMD3ZNP DMD3ZNP DN 2-chloro-2'-C-methyl-tecadenoson DMD3ZNP MI TTJFY5U DMD3ZNP MN Adenosine A3 receptor (ADORA3) DMD3ZNP MT DTT DMD3ZNP MA Inhibitor DMD3ZNP RN 5'-Carbamoyl derivatives of 2'-C-methyl-purine nucleosides as selective A1 adenosine receptor agonists: affinity, efficacy, and selectivity for A1 ... Bioorg Med Chem. 2008 Jan 1;16(1):336-53. DMD3ZNP RU https://pubmed.ncbi.nlm.nih.gov/17933541 DMTPKU8 DI DMTPKU8 DMTPKU8 DN 2-chloro-4-(o-tolyloxy)benzonitrile DMTPKU8 MI TTKPW01 DMTPKU8 MN Androgen receptor messenger RNA (AR mRNA) DMTPKU8 MT DTT DMTPKU8 MA Inhibitor DMTPKU8 RN Diphenyl ethers as androgen receptor antagonists for the topical suppression of sebum production. Bioorg Med Chem Lett. 2009 Apr 15;19(8):2176-8. DMTPKU8 RU https://pubmed.ncbi.nlm.nih.gov/19286380 DMPCRLY DI DMPCRLY DMPCRLY DN 2-chloro-4-(thiazol-2-yl)thieno[3,2-d]pyrimidine DMPCRLY MI TTK25J1 DMPCRLY MN Adenosine A1 receptor (ADORA1) DMPCRLY MT DTT DMPCRLY MA Inhibitor DMPCRLY RN Antagonists of the human adenosine A2A receptor. Part 2: Design and synthesis of 4-arylthieno[3,2-d]pyrimidine derivatives. Bioorg Med Chem Lett. 2008 May 1;18(9):2920-3. DMPCRLY RU https://pubmed.ncbi.nlm.nih.gov/18407496 DMPCRLY DI DMPCRLY DMPCRLY DN 2-chloro-4-(thiazol-2-yl)thieno[3,2-d]pyrimidine DMPCRLY MI TTM2AOE DMPCRLY MN Adenosine A2a receptor (ADORA2A) DMPCRLY MT DTT DMPCRLY MA Inhibitor DMPCRLY RN Antagonists of the human adenosine A2A receptor. Part 2: Design and synthesis of 4-arylthieno[3,2-d]pyrimidine derivatives. Bioorg Med Chem Lett. 2008 May 1;18(9):2920-3. DMPCRLY RU https://pubmed.ncbi.nlm.nih.gov/18407496 DMC5OQ3 DI DMC5OQ3 DMC5OQ3 DN 2-chloro-4-(thiophen-2-yl)thieno[3,2-d]pyrimidine DMC5OQ3 MI TTK25J1 DMC5OQ3 MN Adenosine A1 receptor (ADORA1) DMC5OQ3 MT DTT DMC5OQ3 MA Inhibitor DMC5OQ3 RN Antagonists of the human adenosine A2A receptor. Part 2: Design and synthesis of 4-arylthieno[3,2-d]pyrimidine derivatives. Bioorg Med Chem Lett. 2008 May 1;18(9):2920-3. DMC5OQ3 RU https://pubmed.ncbi.nlm.nih.gov/18407496 DMC5OQ3 DI DMC5OQ3 DMC5OQ3 DN 2-chloro-4-(thiophen-2-yl)thieno[3,2-d]pyrimidine DMC5OQ3 MI TTM2AOE DMC5OQ3 MN Adenosine A2a receptor (ADORA2A) DMC5OQ3 MT DTT DMC5OQ3 MA Inhibitor DMC5OQ3 RN Antagonists of the human adenosine A2A receptor. Part 2: Design and synthesis of 4-arylthieno[3,2-d]pyrimidine derivatives. Bioorg Med Chem Lett. 2008 May 1;18(9):2920-3. DMC5OQ3 RU https://pubmed.ncbi.nlm.nih.gov/18407496 DM5KR4B DI DM5KR4B DM5KR4B DN 2-Chloro-5-(2-methylquinolin-7-yl)nicotinonitrile DM5KR4B MI TTHS256 DM5KR4B MN Metabotropic glutamate receptor 5 (mGluR5) DM5KR4B MT DTT DM5KR4B MA Inhibitor DM5KR4B RN Structure-activity relationships in a novel series of 7-substituted-aryl quinolines and 5-substituted-aryl benzothiazoles at the metabotropic gluta... Bioorg Med Chem. 2010 May 1;18(9):3026-35. DM5KR4B RU https://pubmed.ncbi.nlm.nih.gov/20382541 DMUGQIV DI DMUGQIV DMUGQIV DN 2-chloro-5-nitro-N-phenylbenzamide DMUGQIV MI DEX5D46 DMUGQIV MN Oxygen-insensitive NADPH nitroreductase A (nfsA) DMUGQIV MT DME DMUGQIV MA Metabolism DMUGQIV RN Effects of bacterial and presystemic nitroreductase metabolism of 2-chloro-5-nitro-N-phenylbenzamide on its mutagenicity and bioavailability. Chem Biol Interact. 2012 Apr 15;197(1):16-22. DMUGQIV RU https://pubmed.ncbi.nlm.nih.gov/22450444 DMUGQIV DI DMUGQIV DMUGQIV DN 2-chloro-5-nitro-N-phenylbenzamide DMUGQIV MI DEOWDK1 DMUGQIV MN Oxygen-insensitive NADPH nitroreductase B (nfsB) DMUGQIV MT DME DMUGQIV MA Metabolism DMUGQIV RN Effects of bacterial and presystemic nitroreductase metabolism of 2-chloro-5-nitro-N-phenylbenzamide on its mutagenicity and bioavailability. Chem Biol Interact. 2012 Apr 15;197(1):16-22. DMUGQIV RU https://pubmed.ncbi.nlm.nih.gov/22450444 DMUGQIV DI DMUGQIV DMUGQIV DN 2-chloro-5-nitro-N-phenylbenzamide DMUGQIV MI TTZMAO3 DMUGQIV MN Peroxisome proliferator-activated receptor gamma (PPAR-gamma) DMUGQIV MT DTT DMUGQIV MA Inhibitor DMUGQIV RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DMUGQIV RU https://pubmed.ncbi.nlm.nih.gov/10592235 DMUGQIV DI DMUGQIV DMUGQIV DN 2-chloro-5-nitro-N-phenylbenzamide DMUGQIV MI TTT2SVW DMUGQIV MN PPAR-gamma messenger RNA (PPARG mRNA) DMUGQIV MT DTT DMUGQIV MA Inhibitor DMUGQIV RN Tryptophan-containing dipeptide derivatives as potent PPARgamma antagonists: design, synthesis, biological evaluation, and molecular modeling. Eur J Med Chem. 2008 Dec;43(12):2699-716. DMUGQIV RU https://pubmed.ncbi.nlm.nih.gov/18329752 DMUGQIV DI DMUGQIV DMUGQIV DN 2-chloro-5-nitro-N-phenylbenzamide DMUGQIV MI TT6PEUO DMUGQIV MN Retinoic acid receptor RXR-alpha (RXRA) DMUGQIV MT DTT DMUGQIV MA Inhibitor DMUGQIV RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DMUGQIV RU https://pubmed.ncbi.nlm.nih.gov/10592235 DML0S8M DI DML0S8M DML0S8M DN 2-chloro-6(methylamino)purine DML0S8M MI TT7RJY8 DML0S8M MN Xanthine dehydrogenase/oxidase (XDH) DML0S8M MT DTT DML0S8M MA Inhibitor DML0S8M RN The screening and characterization of 6-aminopurine-based xanthine oxidase inhibitors. Bioorg Med Chem. 2007 May 15;15(10):3450-6. DML0S8M RU https://pubmed.ncbi.nlm.nih.gov/17379526 DMYPQEW DI DMYPQEW DMYPQEW DN 2-chloroadenosine DMYPQEW MI TTK25J1 DMYPQEW MN Adenosine A1 receptor (ADORA1) DMYPQEW MT DTT DMYPQEW MA Agonist DMYPQEW RN Identification of the adenine binding site of the human A1 adenosine receptor. J Biol Chem. 1999 Feb 5;274(6):3617-21. DMYPQEW RU https://pubmed.ncbi.nlm.nih.gov/9920910 DMYPQEW DI DMYPQEW DMYPQEW DN 2-chloroadenosine DMYPQEW MI TTNE7KG DMYPQEW MN Adenosine A2b receptor (ADORA2B) DMYPQEW MT DTT DMYPQEW MA Agonist DMYPQEW RN Adenosine receptor activation in human fibroblasts: nucleoside agonists and antagonists. Can J Physiol Pharmacol. 1980 Jun;58(6):673-91. DMYPQEW RU https://pubmed.ncbi.nlm.nih.gov/6253037 DMYPQEW DI DMYPQEW DMYPQEW DN 2-chloroadenosine DMYPQEW MI TTJFY5U DMYPQEW MN Adenosine A3 receptor (ADORA3) DMYPQEW MT DTT DMYPQEW MA Agonist DMYPQEW RN A binding site model and structure-activity relationships for the rat A3 adenosine receptor. Mol Pharmacol. 1994 Jun;45(6):1101-11. DMYPQEW RU https://pubmed.ncbi.nlm.nih.gov/8022403 DMQUDA9 DI DMQUDA9 DMQUDA9 DN 2-chloroadenosine-5-triphosphate DMQUDA9 MI TTA93TL DMQUDA9 MN P2Y purinoceptor 1 (P2RY1) DMQUDA9 MT DTT DMQUDA9 MA Antagonist DMQUDA9 RN ATP derivatives are antagonists of the P2Y1 receptor: similarities to the platelet ADP receptor. Mol Pharmacol. 1998 Apr;53(4):727-33. DMQUDA9 RU https://pubmed.ncbi.nlm.nih.gov/9547364 DMI89RL DI DMI89RL DMI89RL DN 2-Chlorobenzenemethanethiol DMI89RL MI TTZJYKH DMI89RL MN Indoleamine 2,3-dioxygenase 1 (IDO1) DMI89RL MT DTT DMI89RL MA Inhibitor DMI89RL RN S-benzylisothiourea derivatives as small-molecule inhibitors of indoleamine-2,3-dioxygenase. Bioorg Med Chem Lett. 2010 Sep 1;20(17):5126-9. DMI89RL RU https://pubmed.ncbi.nlm.nih.gov/20688518 DMR8M36 DI DMR8M36 DMR8M36 DN 2-Chloro-N-(2-morpholinoethyl)nicotinamide DMR8M36 MI TT3WG5C DMR8M36 MN Monoamine oxidase type A (MAO-A) DMR8M36 MT DTT DMR8M36 MA Inhibitor DMR8M36 RN Design of novel nicotinamides as potent and selective monoamine oxidase a inhibitors. Bioorg Med Chem. 2010 Feb 15;18(4):1659-64. DMR8M36 RU https://pubmed.ncbi.nlm.nih.gov/20117937 DMR8M36 DI DMR8M36 DMR8M36 DN 2-Chloro-N-(2-morpholinoethyl)nicotinamide DMR8M36 MI TTGP7BY DMR8M36 MN Monoamine oxidase type B (MAO-B) DMR8M36 MT DTT DMR8M36 MA Inhibitor DMR8M36 RN Design of novel nicotinamides as potent and selective monoamine oxidase a inhibitors. Bioorg Med Chem. 2010 Feb 15;18(4):1659-64. DMR8M36 RU https://pubmed.ncbi.nlm.nih.gov/20117937 DM2W71L DI DM2W71L DM2W71L DN 2-chloro-N-(3-(3-chlorobenzamido)phenyl)benzamide DM2W71L MI TTHS256 DM2W71L MN Metabotropic glutamate receptor 5 (mGluR5) DM2W71L MT DTT DM2W71L MA Inhibitor DM2W71L RN Synthesis and SAR of novel, non-MPEP chemotype mGluR5 NAMs identified by functional HTS. Bioorg Med Chem Lett. 2009 Dec 1;19(23):6502-6. DM2W71L RU https://pubmed.ncbi.nlm.nih.gov/19875287 DM5S1DW DI DM5S1DW DM5S1DW DN 2-Chloro-N-(3-morpholinopropyl)nicotinamide DM5S1DW MI TT3WG5C DM5S1DW MN Monoamine oxidase type A (MAO-A) DM5S1DW MT DTT DM5S1DW MA Inhibitor DM5S1DW RN Design of novel nicotinamides as potent and selective monoamine oxidase a inhibitors. Bioorg Med Chem. 2010 Feb 15;18(4):1659-64. DM5S1DW RU https://pubmed.ncbi.nlm.nih.gov/20117937 DM5S1DW DI DM5S1DW DM5S1DW DN 2-Chloro-N-(3-morpholinopropyl)nicotinamide DM5S1DW MI TTGP7BY DM5S1DW MN Monoamine oxidase type B (MAO-B) DM5S1DW MT DTT DM5S1DW MA Inhibitor DM5S1DW RN Design of novel nicotinamides as potent and selective monoamine oxidase a inhibitors. Bioorg Med Chem. 2010 Feb 15;18(4):1659-64. DM5S1DW RU https://pubmed.ncbi.nlm.nih.gov/20117937 DMBKVM4 DI DMBKVM4 DMBKVM4 DN 2-chloro-N-(6-cyanopyridin-3-yl)propanamide DMBKVM4 MI TTCJG29 DMBKVM4 MN Serine/threonine-protein kinase mTOR (mTOR) DMBKVM4 MT DTT DMBKVM4 MA Inhibitor DMBKVM4 RN Synthesis and therapeutic evaluation of pyridyl based novel mTOR inhibitors. Bioorg Med Chem Lett. 2009 Jun 1;19(11):2949-52. DMBKVM4 RU https://pubmed.ncbi.nlm.nih.gov/19409777 DMLDQ6I DI DMLDQ6I DMLDQ6I DN 2-chloro-N-(o-tolylcarbamoyl)benzamide DMLDQ6I MI TTSFWA7 DMLDQ6I MN Plasmodium CDK Pfmrk (Malaria Pfmrk) DMLDQ6I MT DTT DMLDQ6I MA Inhibitor DMLDQ6I RN Activity of substituted thiophene sulfonamides against malarial and mammalian cyclin dependent protein kinases, Bioorg. Med. Chem. Lett. 20(13):3863-3867 (2010). DMLDQ6I RU http://www.sciencedirect.com/science/article/pii/S0960894X10006803 DM2E3X5 DI DM2E3X5 DM2E3X5 DN 2-Chlorophenol DM2E3X5 MI TTQBR95 DM2E3X5 MN Stress-activated protein kinase 2a (p38 alpha) DM2E3X5 MT DTT DM2E3X5 MA Inhibitor DM2E3X5 RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DM2E3X5 RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMXYTGU DI DMXYTGU DMXYTGU DN 2-Cinnamamido-N1-hydroxy-N4-octylsuccinamide DMXYTGU MI TTPHMWB DMXYTGU MN Aminopeptidase N (ANPEP) DMXYTGU MT DTT DMXYTGU MA Inhibitor DMXYTGU RN Design, synthesis, and preliminary studies of the activity of novel derivatives of N-cinnamoyl-L-aspartic acid as inhibitors of aminopeptidase N/CD13. Bioorg Med Chem. 2009 Oct 15;17(20):7398-404. DMXYTGU RU https://pubmed.ncbi.nlm.nih.gov/19782572 DMI6FZN DI DMI6FZN DMI6FZN DN 2-Cinnamamido-N1-hydroxy-N4-pentylsuccinamide DMI6FZN MI TTPHMWB DMI6FZN MN Aminopeptidase N (ANPEP) DMI6FZN MT DTT DMI6FZN MA Inhibitor DMI6FZN RN Design, synthesis, and preliminary studies of the activity of novel derivatives of N-cinnamoyl-L-aspartic acid as inhibitors of aminopeptidase N/CD13. Bioorg Med Chem. 2009 Oct 15;17(20):7398-404. DMI6FZN RU https://pubmed.ncbi.nlm.nih.gov/19782572 DMRNGK7 DI DMRNGK7 DMRNGK7 DN 2-Cinnamamido-N4-hexyl-N1-hydroxysuccinamide DMRNGK7 MI TTPHMWB DMRNGK7 MN Aminopeptidase N (ANPEP) DMRNGK7 MT DTT DMRNGK7 MA Inhibitor DMRNGK7 RN Design, synthesis, and preliminary studies of the activity of novel derivatives of N-cinnamoyl-L-aspartic acid as inhibitors of aminopeptidase N/CD13. Bioorg Med Chem. 2009 Oct 15;17(20):7398-404. DMRNGK7 RU https://pubmed.ncbi.nlm.nih.gov/19782572 DM4235F DI DM4235F DM4235F DN 2-Cl-ADP(alpha-BH3) DM4235F MI TTA93TL DM4235F MN P2Y purinoceptor 1 (P2RY1) DM4235F MT DTT DM4235F MA Agonist DM4235F RN Highly efficient biocompatible neuroprotectants with dual activity as antioxidants and P2Y receptor agonists. J Med Chem. 2013 Jun 27;56(12):4938-52. DM4235F RU https://pubmed.ncbi.nlm.nih.gov/23751098 DMCN6PY DI DMCN6PY DMCN6PY DN 2-cyano-3-(3,4-dihydroxyphenyl)acrylamide DMCN6PY MI TTGKNB4 DMCN6PY MN Epidermal growth factor receptor (EGFR) DMCN6PY MT DTT DMCN6PY MA Inhibitor DMCN6PY RN Protein-tyrosine kinase inhibition: mechanism-based discovery of antitumor agents. J Nat Prod. 1992 Nov;55(11):1529-60. DMCN6PY RU https://pubmed.ncbi.nlm.nih.gov/1479375 DM2U1N5 DI DM2U1N5 DM2U1N5 DN 2-Cyclohex-1-enylethynyl-pyridine DM2U1N5 MI TTHS256 DM2U1N5 MN Metabotropic glutamate receptor 5 (mGluR5) DM2U1N5 MT DTT DM2U1N5 MA Inhibitor DM2U1N5 RN Cyclohexenyl- and dehydropiperidinyl-alkynyl pyridines as potent metabotropic glutamate subtype 5 (mGlu5) receptor antagonists. Bioorg Med Chem Lett. 2005 Oct 15;15(20):4589-93. DM2U1N5 RU https://pubmed.ncbi.nlm.nih.gov/16115767 DMS1T0V DI DMS1T0V DMS1T0V DN 2-Cyclohexylacetic acidbiphenyl-3-yl ester DMS1T0V MI TTDP1UC DMS1T0V MN Fatty acid amide hydrolase (FAAH) DMS1T0V MT DTT DMS1T0V MA Inhibitor DMS1T0V RN Synthesis and quantitative structure-activity relationship of fatty acid amide hydrolase inhibitors: modulation at the N-portion of biphenyl-3-yl a... J Med Chem. 2008 Jun 26;51(12):3487-98. DMS1T0V RU https://pubmed.ncbi.nlm.nih.gov/18507372 DMFBD3K DI DMFBD3K DMFBD3K DN 2-cyclohexylamido-5-sulfonamidoindane DMFBD3K MI TTHQPL7 DMFBD3K MN Carbonic anhydrase I (CA-I) DMFBD3K MT DTT DMFBD3K MA Inhibitor DMFBD3K RN Indanesulfonamides as carbonic anhydrase inhibitors. Toward structure-based design of selective inhibitors of the tumor-associated isozyme CA IX. J Med Chem. 2006 May 4;49(9):2743-9. DMFBD3K RU https://pubmed.ncbi.nlm.nih.gov/16640335 DMFBD3K DI DMFBD3K DMFBD3K DN 2-cyclohexylamido-5-sulfonamidoindane DMFBD3K MI TTANPDJ DMFBD3K MN Carbonic anhydrase II (CA-II) DMFBD3K MT DTT DMFBD3K MA Inhibitor DMFBD3K RN Indanesulfonamides as carbonic anhydrase inhibitors. Toward structure-based design of selective inhibitors of the tumor-associated isozyme CA IX. J Med Chem. 2006 May 4;49(9):2743-9. DMFBD3K RU https://pubmed.ncbi.nlm.nih.gov/16640335 DMFBD3K DI DMFBD3K DMFBD3K DN 2-cyclohexylamido-5-sulfonamidoindane DMFBD3K MI TT2LVK8 DMFBD3K MN Carbonic anhydrase IX (CA-IX) DMFBD3K MT DTT DMFBD3K MA Inhibitor DMFBD3K RN Indanesulfonamides as carbonic anhydrase inhibitors. Toward structure-based design of selective inhibitors of the tumor-associated isozyme CA IX. J Med Chem. 2006 May 4;49(9):2743-9. DMFBD3K RU https://pubmed.ncbi.nlm.nih.gov/16640335 DMFMZRB DI DMFMZRB DMFMZRB DN 2-cyclohexylamino-pyridine-2-carbonitrile DMFMZRB MI TTDZN01 DMFMZRB MN Cathepsin K (CTSK) DMFMZRB MT DTT DMFMZRB MA Inhibitor DMFMZRB RN 2-Cyano-pyrimidines: a new chemotype for inhibitors of the cysteine protease cathepsin K. J Med Chem. 2007 Feb 22;50(4):591-4. DMFMZRB RU https://pubmed.ncbi.nlm.nih.gov/17256925 DMMIGXO DI DMMIGXO DMMIGXO DN 2-cyclohexylamino-pyrimidine-4-carbonitrile DMMIGXO MI TTDZN01 DMMIGXO MN Cathepsin K (CTSK) DMMIGXO MT DTT DMMIGXO MA Inhibitor DMMIGXO RN 2-Cyano-pyrimidines: a new chemotype for inhibitors of the cysteine protease cathepsin K. J Med Chem. 2007 Feb 22;50(4):591-4. DMMIGXO RU https://pubmed.ncbi.nlm.nih.gov/17256925 DM2JZ84 DI DM2JZ84 DM2JZ84 DN 2-Cyclohexylethynyl-pyridine DM2JZ84 MI TTHS256 DM2JZ84 MN Metabotropic glutamate receptor 5 (mGluR5) DM2JZ84 MT DTT DM2JZ84 MA Inhibitor DM2JZ84 RN Cyclohexenyl- and dehydropiperidinyl-alkynyl pyridines as potent metabotropic glutamate subtype 5 (mGlu5) receptor antagonists. Bioorg Med Chem Lett. 2005 Oct 15;15(20):4589-93. DM2JZ84 RU https://pubmed.ncbi.nlm.nih.gov/16115767 DMF6PMU DI DMF6PMU DMF6PMU DN 2-Cyclohexyl-N-(4-methoxy-phenyl)-acetamide DMF6PMU MI TT7WVHI DMF6PMU MN Soluble epoxide hydrolase (EPHX2) DMF6PMU MT DTT DMF6PMU MA Inhibitor DMF6PMU RN Optimization of amide-based inhibitors of soluble epoxide hydrolase with improved water solubility. J Med Chem. 2005 May 19;48(10):3621-9. DMF6PMU RU https://pubmed.ncbi.nlm.nih.gov/15887969 DM89CLH DI DM89CLH DM89CLH DN 2-Cyclohexyl-N-phenethyl-acetamide DM89CLH MI TT7WVHI DM89CLH MN Soluble epoxide hydrolase (EPHX2) DM89CLH MT DTT DM89CLH MA Inhibitor DM89CLH RN Optimization of amide-based inhibitors of soluble epoxide hydrolase with improved water solubility. J Med Chem. 2005 May 19;48(10):3621-9. DM89CLH RU https://pubmed.ncbi.nlm.nih.gov/15887969 DMBJUP5 DI DMBJUP5 DMBJUP5 DN 2-Cyclohexyl-N-phenyl-acetamide DMBJUP5 MI TT7WVHI DMBJUP5 MN Soluble epoxide hydrolase (EPHX2) DMBJUP5 MT DTT DMBJUP5 MA Inhibitor DMBJUP5 RN Optimization of amide-based inhibitors of soluble epoxide hydrolase with improved water solubility. J Med Chem. 2005 May 19;48(10):3621-9. DMBJUP5 RU https://pubmed.ncbi.nlm.nih.gov/15887969 DMVP6CW DI DMVP6CW DMVP6CW DN 2-Cyclopent-1-enylethynyl-pyridine DMVP6CW MI TTHS256 DMVP6CW MN Metabotropic glutamate receptor 5 (mGluR5) DMVP6CW MT DTT DMVP6CW MA Inhibitor DMVP6CW RN Cyclohexenyl- and dehydropiperidinyl-alkynyl pyridines as potent metabotropic glutamate subtype 5 (mGlu5) receptor antagonists. Bioorg Med Chem Lett. 2005 Oct 15;15(20):4589-93. DMVP6CW RU https://pubmed.ncbi.nlm.nih.gov/16115767 DM6CZAN DI DM6CZAN DM6CZAN DN 2-Cyclopentyl-1H-imidazo[4,5-c]quinolin-4-ylamine DM6CZAN MI TTK25J1 DM6CZAN MN Adenosine A1 receptor (ADORA1) DM6CZAN MT DTT DM6CZAN MA Inhibitor DM6CZAN RN 1H-imidazo[4,5-c]quinolin-4-amines: novel non-xanthine adenosine antagonists. J Med Chem. 1991 Mar;34(3):1202-6. DM6CZAN RU https://pubmed.ncbi.nlm.nih.gov/2002461 DM6CZAN DI DM6CZAN DM6CZAN DN 2-Cyclopentyl-1H-imidazo[4,5-c]quinolin-4-ylamine DM6CZAN MI TTM2AOE DM6CZAN MN Adenosine A2a receptor (ADORA2A) DM6CZAN MT DTT DM6CZAN MA Inhibitor DM6CZAN RN 1H-imidazo[4,5-c]quinolin-4-amines: novel non-xanthine adenosine antagonists. J Med Chem. 1991 Mar;34(3):1202-6. DM6CZAN RU https://pubmed.ncbi.nlm.nih.gov/2002461 DM6CZAN DI DM6CZAN DM6CZAN DN 2-Cyclopentyl-1H-imidazo[4,5-c]quinolin-4-ylamine DM6CZAN MI TTNE7KG DM6CZAN MN Adenosine A2b receptor (ADORA2B) DM6CZAN MT DTT DM6CZAN MA Inhibitor DM6CZAN RN 1H-imidazo[4,5-c]quinolin-4-amines: novel non-xanthine adenosine antagonists. J Med Chem. 1991 Mar;34(3):1202-6. DM6CZAN RU https://pubmed.ncbi.nlm.nih.gov/2002461 DMS947W DI DMS947W DMS947W DN 2-Cyclopentylaminomethyl-pyrrolidine-3,4-diol DMS947W MI TTXWASR DMS947W MN Intestinal maltase-glucoamylase (MGAM) DMS947W MT DTT DMS947W MA Inhibitor DMS947W RN Derivatives of (2R,3R,4S)-2-aminomethylpyrrolidine-3,4-diol are selective alpha-mannosidase inhibitors. Bioorg Med Chem Lett. 2001 Sep 17;11(18):2489-93. DMS947W RU https://pubmed.ncbi.nlm.nih.gov/11549453 DMRS6LH DI DMRS6LH DMRS6LH DN 2-Cyclopropanecarbonyl-cyclohexane-1,3-dione DMRS6LH MI TT8DSFC DMRS6LH MN Hydroxyphenylpyruvate dioxygenase (HPD) DMRS6LH MT DTT DMRS6LH MA Inhibitor DMRS6LH RN SAR studies of 2-o-substituted-benzoyl- and 2-alkanoyl-cyclohexane-1,3-diones as inhibitors of 4-hydroxyphenylpyruvate dioxygenase. Bioorg Med Chem Lett. 2000 May 1;10(9):843-5. DMRS6LH RU https://pubmed.ncbi.nlm.nih.gov/10853644 DM0W2QB DI DM0W2QB DM0W2QB DN 2-Cyclopropylmethylenepropanal DM0W2QB MI TTB2MXP DM0W2QB MN Angiotensinogenase renin (REN) DM0W2QB MT DTT DM0W2QB MA Inhibitor DM0W2QB RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DM0W2QB RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMIAM5L DI DMIAM5L DMIAM5L DN 2-Deoxy-2,3-Dehydro-N-Acetyl-Neuraminic Acid DMIAM5L MI TT50QJ3 DMIAM5L MN Influenza Neuraminidase (Influ NA) DMIAM5L MT DTT DMIAM5L MA Inhibitor DMIAM5L RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMIAM5L RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMBMK4T DI DMBMK4T DMBMK4T DN 2-Deoxy-2-Amino Glucitol-6-Phosphate DMBMK4T MI TTC67I0 DMBMK4T MN Bacterial Glucosamine-6-phosphate synthase (Bact glmS) DMBMK4T MT DTT DMBMK4T MA Inhibitor DMBMK4T RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMBMK4T RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMMC8IG DI DMMC8IG DMMC8IG DN 2-Deoxy-2fluoro-Glucose DMMC8IG MI TTA0OSE DMMC8IG MN Lactase-phlorizin hydrolase (LCT) DMMC8IG MT DTT DMMC8IG MA Inhibitor DMMC8IG RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMMC8IG RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMG7CAU DI DMG7CAU DMG7CAU DN 2'-Deoxycytidine-5'-Monophosphate DMG7CAU MI TTU6BFZ DMG7CAU MN Candida Thymidylate synthase (Candi TMP1) DMG7CAU MT DTT DMG7CAU MA Inhibitor DMG7CAU RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMG7CAU RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMMPL3D DI DMMPL3D DMMPL3D DN 2-Deoxy-Glucose-6-Phosphate DMMPL3D MI TTZHY6R DMMPL3D MN Glycogen phosphorylase muscle form (GP) DMMPL3D MT DTT DMMPL3D MA Inhibitor DMMPL3D RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMMPL3D RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMY9FDT DI DMY9FDT DMY9FDT DN 2'-Deoxyguanosine-5'-Monophosphate DMY9FDT MI TTU6BFZ DMY9FDT MN Candida Thymidylate synthase (Candi TMP1) DMY9FDT MT DTT DMY9FDT MA Inhibitor DMY9FDT RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMY9FDT RU https://pubmed.ncbi.nlm.nih.gov/17139284 DM9OEJT DI DM9OEJT DM9OEJT DN 2'-deoxythymidine triphosphate DM9OEJT MI TTIU7X1 DM9OEJT MN Herpes simplex virus DNA polymerase UL30 (HSV UL30) DM9OEJT MT DTT DM9OEJT MA Inhibitor DM9OEJT RN Inhibition of human hepatitis B virus DNA polymerase and duck hepatitis B virus DNA polymerase by triphosphates of thymidine analogs and pharmacokinetic properties of the corresponding nucleosides. JMed Virol. 1988 Dec;26(4):353-62. DM9OEJT RU https://pubmed.ncbi.nlm.nih.gov/3145322 DM9OEJT DI DM9OEJT DM9OEJT DN 2'-deoxythymidine triphosphate DM9OEJT MI TT84ETX DM9OEJT MN Human immunodeficiency virus Reverse transcriptase (HIV RT) DM9OEJT MT DTT DM9OEJT MA Inhibitor DM9OEJT RN Synthesis of 2',3'-dideoxynucleoside 5'-alpha-P-borano-beta,gamma-(difluoromethylene)triphosphates and their inhibition of HIV-1 reverse transcript... J Med Chem. 2005 Apr 7;48(7):2695-700. DM9OEJT RU https://pubmed.ncbi.nlm.nih.gov/15801860 DM9OEJT DI DM9OEJT DM9OEJT DN 2'-deoxythymidine triphosphate DM9OEJT MI TT5B8AX DM9OEJT MN Mycobacterium Thymidine monophosphate kinase (MycB tmk) DM9OEJT MT DTT DM9OEJT MA Inhibitor DM9OEJT RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DM9OEJT RU https://pubmed.ncbi.nlm.nih.gov/17139284 DM9OEJT DI DM9OEJT DM9OEJT DN 2'-deoxythymidine triphosphate DM9OEJT MI TTP3QRF DM9OEJT MN Thymidine kinase 1 (TK1) DM9OEJT MT DTT DM9OEJT MA Inhibitor DM9OEJT RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DM9OEJT RU https://pubmed.ncbi.nlm.nih.gov/17139284 DM1HMWA DI DM1HMWA DM1HMWA DN 2'-Deoxyuridine DM1HMWA MI TTU6BFZ DM1HMWA MN Candida Thymidylate synthase (Candi TMP1) DM1HMWA MT DTT DM1HMWA MA Inhibitor DM1HMWA RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DM1HMWA RU https://pubmed.ncbi.nlm.nih.gov/17139284 DM1HMWA DI DM1HMWA DM1HMWA DN 2'-Deoxyuridine DM1HMWA MI TTP3QRF DM1HMWA MN Thymidine kinase 1 (TK1) DM1HMWA MT DTT DM1HMWA MA Inhibitor DM1HMWA RN Species- or isozyme-specific enzyme inhibitors. 5. Differential effects of thymidine substituents on affinity for rat thymidine kinase isozymes. J Med Chem. 1982 Jun;25(6):644-9. DM1HMWA RU https://pubmed.ncbi.nlm.nih.gov/7097717 DMXV27U DI DMXV27U DMXV27U DN 2'-deoxyuridine 5'-alpha,beta-imido-diphosphate DMXV27U MI TTY8KJS DMXV27U MN Bacterial Deoxyuridine triphosphate nucleotidohydrolase (Bact dut) DMXV27U MT DTT DMXV27U MA Inhibitor DMXV27U RN DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Nucleic Acids Res. 2011 Jan;39(Database issue):D1035-41. DMXV27U RU https://pubmed.ncbi.nlm.nih.gov/21059682 DMOHABR DI DMOHABR DMOHABR DN 2'-Deoxyuridine 5'-Alpha,Beta-Imido-Triphosphate DMOHABR MI TTY8KJS DMOHABR MN Bacterial Deoxyuridine triphosphate nucleotidohydrolase (Bact dut) DMOHABR MT DTT DMOHABR MA Inhibitor DMOHABR RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMOHABR RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMPV1LU DI DMPV1LU DMPV1LU DN 2'-deoxyuridylic acid DMPV1LU MI TTY8KJS DMPV1LU MN Bacterial Deoxyuridine triphosphate nucleotidohydrolase (Bact dut) DMPV1LU MT DTT DMPV1LU MA Inhibitor DMPV1LU RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMPV1LU RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMPV1LU DI DMPV1LU DMPV1LU DN 2'-deoxyuridylic acid DMPV1LU MI TTU6BFZ DMPV1LU MN Candida Thymidylate synthase (Candi TMP1) DMPV1LU MT DTT DMPV1LU MA Inhibitor DMPV1LU RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMPV1LU RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMPV1LU DI DMPV1LU DMPV1LU DN 2'-deoxyuridylic acid DMPV1LU MI DEH4O6C DMPV1LU MN Thymidylate synthase (thyA) DMPV1LU MT DME DMPV1LU MA Metabolism DMPV1LU RN Role of the conserved tryptophan 82 of Lactobacillus casei thymidylate synthase. Chem Biol. 1995 Sep;2(9):609-14. DMPV1LU RU https://pubmed.ncbi.nlm.nih.gov/9383465 DMPV1LU DI DMPV1LU DMPV1LU DN 2'-deoxyuridylic acid DMPV1LU MI DEASG0Q DMPV1LU MN Thymidylate synthase (TYMS) DMPV1LU MT DME DMPV1LU MA Metabolism DMPV1LU RN Distribution of mutations in human thymidylate synthase yielding resistance to 5-fluorodeoxyuridine. J Biol Chem. 2002 Sep 27;277(39):36304-11. DMPV1LU RU https://www.ncbi.nlm.nih.gov/pubmed/?term=12147691 DM4A527 DI DM4A527 DM4A527 DN 2-dibenzofuran-4-yl-6-morpholin-4-yl-pyran-4-one DM4A527 MI TTK3PY9 DM4A527 MN DNA-dependent protein kinase catalytic (PRKDC) DM4A527 MT DTT DM4A527 MA Inhibitor DM4A527 RN Pyranone, thiopyranone, and pyridone inhibitors of phosphatidylinositol 3-kinase related kinases. Structure-activity relationships for DNA-dependen... J Med Chem. 2007 Apr 19;50(8):1958-72. DM4A527 RU https://pubmed.ncbi.nlm.nih.gov/17371003 DMF50YH DI DMF50YH DMF50YH DN 2-Dipropylamino-1,2,3,4-tetrahydro-anthracen-9-ol DMF50YH MI TTSQIFT DMF50YH MN 5-HT 1A receptor (HTR1A) DMF50YH MT DTT DMF50YH MA Inhibitor DMF50YH RN Synthesis of new derivatives of 8-OH-DPAT: Influence of substitution on the aromatic ring on the pharmacological profile, Bioorg. Med. Chem. Lett. 3(10):2035-2038 (1993). DMF50YH RU http://www.sciencedirect.com/science/article/pii/S0960894X0181009X DM2PDGO DI DM2PDGO DM2PDGO DN 2-EPI-2-THIOSALVINORIN A DM2PDGO MI TTQW87Y DM2PDGO MN Opioid receptor kappa (OPRK1) DM2PDGO MT DTT DM2PDGO MA Inhibitor DM2PDGO RN Convenient synthesis and in vitro pharmacological activity of 2-thioanalogs of salvinorins A and B. Bioorg Med Chem Lett. 2007 Apr 15;17(8):2229-32. DM2PDGO RU https://pubmed.ncbi.nlm.nih.gov/17303418 DMZXIW0 DI DMZXIW0 DMZXIW0 DN 2-EPI-2-THIOSALVINORIN B DMZXIW0 MI TTQW87Y DMZXIW0 MN Opioid receptor kappa (OPRK1) DMZXIW0 MT DTT DMZXIW0 MA Inhibitor DMZXIW0 RN Convenient synthesis and in vitro pharmacological activity of 2-thioanalogs of salvinorins A and B. Bioorg Med Chem Lett. 2007 Apr 15;17(8):2229-32. DMZXIW0 RU https://pubmed.ncbi.nlm.nih.gov/17303418 DMNVJY0 DI DMNVJY0 DMNVJY0 DN 2'-epi-guianin DMNVJY0 MI TT8NGED DMNVJY0 MN Prostaglandin G/H synthase 1 (COX-1) DMNVJY0 MT DTT DMNVJY0 MA Inhibitor DMNVJY0 RN COX, LOX and platelet aggregation inhibitory properties of Lauraceae neolignans. Bioorg Med Chem Lett. 2009 Dec 15;19(24):6922-5. DMNVJY0 RU https://pubmed.ncbi.nlm.nih.gov/19880317 DMGRA3T DI DMGRA3T DMGRA3T DN 2-ethoxy-5-(m-tolylethynyl)pyrimidine DMGRA3T MI TTHS256 DMGRA3T MN Metabotropic glutamate receptor 5 (mGluR5) DMGRA3T MT DTT DMGRA3T MA Inhibitor DMGRA3T RN Discovery of molecular switches that modulate modes of metabotropic glutamate receptor subtype 5 (mGlu5) pharmacology in vitro and in vivo within a... J Med Chem. 2009 Jul 23;52(14):4103-6. DMGRA3T RU https://pubmed.ncbi.nlm.nih.gov/19537763 DM0BHKM DI DM0BHKM DM0BHKM DN 2-ethyl-4-(furan-2-yl)thieno[3,2-d]pyrimidine DM0BHKM MI TTK25J1 DM0BHKM MN Adenosine A1 receptor (ADORA1) DM0BHKM MT DTT DM0BHKM MA Inhibitor DM0BHKM RN Antagonists of the human adenosine A2A receptor. Part 2: Design and synthesis of 4-arylthieno[3,2-d]pyrimidine derivatives. Bioorg Med Chem Lett. 2008 May 1;18(9):2920-3. DM0BHKM RU https://pubmed.ncbi.nlm.nih.gov/18407496 DM0BHKM DI DM0BHKM DM0BHKM DN 2-ethyl-4-(furan-2-yl)thieno[3,2-d]pyrimidine DM0BHKM MI TTM2AOE DM0BHKM MN Adenosine A2a receptor (ADORA2A) DM0BHKM MT DTT DM0BHKM MA Inhibitor DM0BHKM RN Antagonists of the human adenosine A2A receptor. Part 2: Design and synthesis of 4-arylthieno[3,2-d]pyrimidine derivatives. Bioorg Med Chem Lett. 2008 May 1;18(9):2920-3. DM0BHKM RU https://pubmed.ncbi.nlm.nih.gov/18407496 DMR0IEK DI DMR0IEK DMR0IEK DN 2-ethyl-4-(furan-3-yl)thieno[3,2-d]pyrimidine DMR0IEK MI TTK25J1 DMR0IEK MN Adenosine A1 receptor (ADORA1) DMR0IEK MT DTT DMR0IEK MA Inhibitor DMR0IEK RN Antagonists of the human adenosine A2A receptor. Part 2: Design and synthesis of 4-arylthieno[3,2-d]pyrimidine derivatives. Bioorg Med Chem Lett. 2008 May 1;18(9):2920-3. DMR0IEK RU https://pubmed.ncbi.nlm.nih.gov/18407496 DMR0IEK DI DMR0IEK DMR0IEK DN 2-ethyl-4-(furan-3-yl)thieno[3,2-d]pyrimidine DMR0IEK MI TTM2AOE DMR0IEK MN Adenosine A2a receptor (ADORA2A) DMR0IEK MT DTT DMR0IEK MA Inhibitor DMR0IEK RN Antagonists of the human adenosine A2A receptor. Part 2: Design and synthesis of 4-arylthieno[3,2-d]pyrimidine derivatives. Bioorg Med Chem Lett. 2008 May 1;18(9):2920-3. DMR0IEK RU https://pubmed.ncbi.nlm.nih.gov/18407496 DMWFR16 DI DMWFR16 DMWFR16 DN 2-ethyl-4-(pyridin-2-yl)thieno[3,2-d]pyrimidine DMWFR16 MI TTK25J1 DMWFR16 MN Adenosine A1 receptor (ADORA1) DMWFR16 MT DTT DMWFR16 MA Inhibitor DMWFR16 RN Antagonists of the human adenosine A2A receptor. Part 2: Design and synthesis of 4-arylthieno[3,2-d]pyrimidine derivatives. Bioorg Med Chem Lett. 2008 May 1;18(9):2920-3. DMWFR16 RU https://pubmed.ncbi.nlm.nih.gov/18407496 DMWFR16 DI DMWFR16 DMWFR16 DN 2-ethyl-4-(pyridin-2-yl)thieno[3,2-d]pyrimidine DMWFR16 MI TTM2AOE DMWFR16 MN Adenosine A2a receptor (ADORA2A) DMWFR16 MT DTT DMWFR16 MA Inhibitor DMWFR16 RN Antagonists of the human adenosine A2A receptor. Part 2: Design and synthesis of 4-arylthieno[3,2-d]pyrimidine derivatives. Bioorg Med Chem Lett. 2008 May 1;18(9):2920-3. DMWFR16 RU https://pubmed.ncbi.nlm.nih.gov/18407496 DMWCGE8 DI DMWCGE8 DMWCGE8 DN 2-ethyl-4-(thiazol-2-yl)thieno[3,2-d]pyrimidine DMWCGE8 MI TTK25J1 DMWCGE8 MN Adenosine A1 receptor (ADORA1) DMWCGE8 MT DTT DMWCGE8 MA Inhibitor DMWCGE8 RN Antagonists of the human adenosine A2A receptor. Part 2: Design and synthesis of 4-arylthieno[3,2-d]pyrimidine derivatives. Bioorg Med Chem Lett. 2008 May 1;18(9):2920-3. DMWCGE8 RU https://pubmed.ncbi.nlm.nih.gov/18407496 DMWCGE8 DI DMWCGE8 DMWCGE8 DN 2-ethyl-4-(thiazol-2-yl)thieno[3,2-d]pyrimidine DMWCGE8 MI TTM2AOE DMWCGE8 MN Adenosine A2a receptor (ADORA2A) DMWCGE8 MT DTT DMWCGE8 MA Inhibitor DMWCGE8 RN Antagonists of the human adenosine A2A receptor. Part 2: Design and synthesis of 4-arylthieno[3,2-d]pyrimidine derivatives. Bioorg Med Chem Lett. 2008 May 1;18(9):2920-3. DMWCGE8 RU https://pubmed.ncbi.nlm.nih.gov/18407496 DMWCGE8 DI DMWCGE8 DMWCGE8 DN 2-ethyl-4-(thiazol-2-yl)thieno[3,2-d]pyrimidine DMWCGE8 MI TTNE7KG DMWCGE8 MN Adenosine A2b receptor (ADORA2B) DMWCGE8 MT DTT DMWCGE8 MA Inhibitor DMWCGE8 RN Antagonists of the human adenosine A2A receptor. Part 2: Design and synthesis of 4-arylthieno[3,2-d]pyrimidine derivatives. Bioorg Med Chem Lett. 2008 May 1;18(9):2920-3. DMWCGE8 RU https://pubmed.ncbi.nlm.nih.gov/18407496 DMWCGE8 DI DMWCGE8 DMWCGE8 DN 2-ethyl-4-(thiazol-2-yl)thieno[3,2-d]pyrimidine DMWCGE8 MI TTJFY5U DMWCGE8 MN Adenosine A3 receptor (ADORA3) DMWCGE8 MT DTT DMWCGE8 MA Inhibitor DMWCGE8 RN Antagonists of the human adenosine A2A receptor. Part 2: Design and synthesis of 4-arylthieno[3,2-d]pyrimidine derivatives. Bioorg Med Chem Lett. 2008 May 1;18(9):2920-3. DMWCGE8 RU https://pubmed.ncbi.nlm.nih.gov/18407496 DMIRSQO DI DMIRSQO DMIRSQO DN 2-ethyl-4-(thiophen-2-yl)thieno[3,2-d]pyrimidine DMIRSQO MI TTK25J1 DMIRSQO MN Adenosine A1 receptor (ADORA1) DMIRSQO MT DTT DMIRSQO MA Inhibitor DMIRSQO RN Antagonists of the human adenosine A2A receptor. Part 2: Design and synthesis of 4-arylthieno[3,2-d]pyrimidine derivatives. Bioorg Med Chem Lett. 2008 May 1;18(9):2920-3. DMIRSQO RU https://pubmed.ncbi.nlm.nih.gov/18407496 DMIRSQO DI DMIRSQO DMIRSQO DN 2-ethyl-4-(thiophen-2-yl)thieno[3,2-d]pyrimidine DMIRSQO MI TTM2AOE DMIRSQO MN Adenosine A2a receptor (ADORA2A) DMIRSQO MT DTT DMIRSQO MA Inhibitor DMIRSQO RN Antagonists of the human adenosine A2A receptor. Part 2: Design and synthesis of 4-arylthieno[3,2-d]pyrimidine derivatives. Bioorg Med Chem Lett. 2008 May 1;18(9):2920-3. DMIRSQO RU https://pubmed.ncbi.nlm.nih.gov/18407496 DMLC8OB DI DMLC8OB DMLC8OB DN 2-Ethyl-5-methoxy-3-piperidin-4-yl-1H-indole DMLC8OB MI TTJS8PY DMLC8OB MN 5-HT 6 receptor (HTR6) DMLC8OB MT DTT DMLC8OB MA Inhibitor DMLC8OB RN 2-Alkyl-3-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indoles as novel 5-HT6 receptor agonists. Bioorg Med Chem Lett. 2005 Oct 1;15(19):4230-4. DMLC8OB RU https://pubmed.ncbi.nlm.nih.gov/16055331 DMN8W1H DI DMN8W1H DMN8W1H DN 2-ethyl-9H-carbazole DMN8W1H MI TTBGTCW DMN8W1H MN Kinesin spindle messenger RNA (KIF11 mRNA) DMN8W1H MT DTT DMN8W1H MA Inhibitor DMN8W1H RN Kinesin spindle protein (KSP) inhibitors with 2,3-fused indole scaffolds. J Med Chem. 2010 Jul 8;53(13):5054-8. DMN8W1H RU https://pubmed.ncbi.nlm.nih.gov/20521839 DMDY3JQ DI DMDY3JQ DMDY3JQ DN 2-ethylamido-5-sulfonamidoindane DMDY3JQ MI TTHQPL7 DMDY3JQ MN Carbonic anhydrase I (CA-I) DMDY3JQ MT DTT DMDY3JQ MA Inhibitor DMDY3JQ RN Indanesulfonamides as carbonic anhydrase inhibitors. Toward structure-based design of selective inhibitors of the tumor-associated isozyme CA IX. J Med Chem. 2006 May 4;49(9):2743-9. DMDY3JQ RU https://pubmed.ncbi.nlm.nih.gov/16640335 DMDY3JQ DI DMDY3JQ DMDY3JQ DN 2-ethylamido-5-sulfonamidoindane DMDY3JQ MI TTANPDJ DMDY3JQ MN Carbonic anhydrase II (CA-II) DMDY3JQ MT DTT DMDY3JQ MA Inhibitor DMDY3JQ RN Indanesulfonamides as carbonic anhydrase inhibitors. Toward structure-based design of selective inhibitors of the tumor-associated isozyme CA IX. J Med Chem. 2006 May 4;49(9):2743-9. DMDY3JQ RU https://pubmed.ncbi.nlm.nih.gov/16640335 DMDY3JQ DI DMDY3JQ DMDY3JQ DN 2-ethylamido-5-sulfonamidoindane DMDY3JQ MI TT2LVK8 DMDY3JQ MN Carbonic anhydrase IX (CA-IX) DMDY3JQ MT DTT DMDY3JQ MA Inhibitor DMDY3JQ RN Indanesulfonamides as carbonic anhydrase inhibitors. Toward structure-based design of selective inhibitors of the tumor-associated isozyme CA IX. J Med Chem. 2006 May 4;49(9):2743-9. DMDY3JQ RU https://pubmed.ncbi.nlm.nih.gov/16640335 DMC10DR DI DMC10DR DMC10DR DN 2-ethylestradiol 3,17-O,O-bis-sulfamate DMC10DR MI TTHM0R1 DMC10DR MN Steryl-sulfatase (STS) DMC10DR MT DTT DMC10DR MA Inhibitor DMC10DR RN 2-substituted estradiol bis-sulfamates, multitargeted antitumor agents: synthesis, in vitro SAR, protein crystallography, and in vivo activity. J Med Chem. 2006 Dec 28;49(26):7683-96. DMC10DR RU https://pubmed.ncbi.nlm.nih.gov/17181151 DMKR47X DI DMKR47X DMKR47X DN 2-ethylquinoline-8-carboxamide DMKR47X MI TTVDSZ0 DMKR47X MN Poly [ADP-ribose] polymerase 1 (PARP1) DMKR47X MT DTT DMKR47X MA Inhibitor DMKR47X RN Design, synthesis, and evaluation in vitro of quinoline-8-carboxamides, a new class of poly(adenosine-diphosphate-ribose)polymerase-1 (PARP-1) inhi... J Med Chem. 2009 Feb 12;52(3):868-77. DMKR47X RU https://pubmed.ncbi.nlm.nih.gov/19117416 DME6VKS DI DME6VKS DME6VKS DN 2-ethynyl-4-(3-fluorophenylethynyl)thiazole DME6VKS MI TTHS256 DME6VKS MN Metabotropic glutamate receptor 5 (mGluR5) DME6VKS MT DTT DME6VKS MA Inhibitor DME6VKS RN Synthesis and structure-activity relationships of 3-[(2-methyl-1,3-thiazol-4-yl)ethynyl]pyridine analogues as potent, noncompetitive metabotropic g... J Med Chem. 2006 Feb 9;49(3):1080-100. DME6VKS RU https://pubmed.ncbi.nlm.nih.gov/16451073 DM2D78W DI DM2D78W DM2D78W DN 2-ethynyl-N6-methoxyadenosine DM2D78W MI TTK25J1 DM2D78W MN Adenosine A1 receptor (ADORA1) DM2D78W MT DTT DM2D78W MA Inhibitor DM2D78W RN N6-methoxy-2-alkynyladenosine derivatives as highly potent and selective ligands at the human A3 adenosine receptor. J Med Chem. 2007 Mar 22;50(6):1222-30. DM2D78W RU https://pubmed.ncbi.nlm.nih.gov/17309246 DM2D78W DI DM2D78W DM2D78W DN 2-ethynyl-N6-methoxyadenosine DM2D78W MI TTM2AOE DM2D78W MN Adenosine A2a receptor (ADORA2A) DM2D78W MT DTT DM2D78W MA Inhibitor DM2D78W RN N6-methoxy-2-alkynyladenosine derivatives as highly potent and selective ligands at the human A3 adenosine receptor. J Med Chem. 2007 Mar 22;50(6):1222-30. DM2D78W RU https://pubmed.ncbi.nlm.nih.gov/17309246 DM2D78W DI DM2D78W DM2D78W DN 2-ethynyl-N6-methoxyadenosine DM2D78W MI TTJFY5U DM2D78W MN Adenosine A3 receptor (ADORA3) DM2D78W MT DTT DM2D78W MA Inhibitor DM2D78W RN N6-methoxy-2-alkynyladenosine derivatives as highly potent and selective ligands at the human A3 adenosine receptor. J Med Chem. 2007 Mar 22;50(6):1222-30. DM2D78W RU https://pubmed.ncbi.nlm.nih.gov/17309246 DMNOAJG DI DMNOAJG DMNOAJG DN 2ewy DMNOAJG MI TT69DB8 DMNOAJG MN Beta-site APP-cleaving enzyme 2 (BACE2) DMNOAJG MT DTT DMNOAJG MA Inhibitor DMNOAJG RN Crystal structure of human BACE2 in complex with a hydroxyethylamine transition-state inhibitor. J Mol Biol. 2006 Jan 13;355(2):249-61. DMNOAJG RU https://pubmed.ncbi.nlm.nih.gov/16305800 DMUGAT8 DI DMUGAT8 DMUGAT8 DN 2-Fluoro-4-[5-(3-hydroxyphenyl)-2-thienyl]phenol DMUGAT8 MI TTXV4FI DMUGAT8 MN Albendazole monooxygenase (CYP3A4) DMUGAT8 MT DTT DMUGAT8 MA Inhibitor DMUGAT8 RN New insights into the SAR and binding modes of bis(hydroxyphenyl)thiophenes and -benzenes: influence of additional substituents on 17beta-hydroxyst... J Med Chem. 2009 Nov 12;52(21):6724-43. DMUGAT8 RU https://pubmed.ncbi.nlm.nih.gov/19831396 DMUGAT8 DI DMUGAT8 DMUGAT8 DN 2-Fluoro-4-[5-(3-hydroxyphenyl)-2-thienyl]phenol DMUGAT8 MI TTVG215 DMUGAT8 MN Debrisoquine 4-hydroxylase (CYP2D6) DMUGAT8 MT DTT DMUGAT8 MA Inhibitor DMUGAT8 RN New insights into the SAR and binding modes of bis(hydroxyphenyl)thiophenes and -benzenes: influence of additional substituents on 17beta-hydroxyst... J Med Chem. 2009 Nov 12;52(21):6724-43. DMUGAT8 RU https://pubmed.ncbi.nlm.nih.gov/19831396 DMUGAT8 DI DMUGAT8 DMUGAT8 DN 2-Fluoro-4-[5-(3-hydroxyphenyl)-2-thienyl]phenol DMUGAT8 MI TTIWB6L DMUGAT8 MN Estradiol 17 beta-dehydrogenase 1 (17-beta-HSD1) DMUGAT8 MT DTT DMUGAT8 MA Inhibitor DMUGAT8 RN New insights into the SAR and binding modes of bis(hydroxyphenyl)thiophenes and -benzenes: influence of additional substituents on 17beta-hydroxyst... J Med Chem. 2009 Nov 12;52(21):6724-43. DMUGAT8 RU https://pubmed.ncbi.nlm.nih.gov/19831396 DMGBEFY DI DMGBEFY DMGBEFY DN 2-Fluoro-4-[5-(3-hydroxyphenyl)-3-thienyl]phenol DMGBEFY MI TTIWB6L DMGBEFY MN Estradiol 17 beta-dehydrogenase 1 (17-beta-HSD1) DMGBEFY MT DTT DMGBEFY MA Inhibitor DMGBEFY RN New insights into the SAR and binding modes of bis(hydroxyphenyl)thiophenes and -benzenes: influence of additional substituents on 17beta-hydroxyst... J Med Chem. 2009 Nov 12;52(21):6724-43. DMGBEFY RU https://pubmed.ncbi.nlm.nih.gov/19831396 DMCGI1S DI DMCGI1S DMCGI1S DN 2-fluoro-5-(3-methylthiophen-2-yl)pyridine DMCGI1S MI TTXV4FI DMCGI1S MN Albendazole monooxygenase (CYP3A4) DMCGI1S MT DTT DMCGI1S MA Inhibitor DMCGI1S RN Synthetic inhibitors of cytochrome P-450 2A6: inhibitory activity, difference spectra, mechanism of inhibition, and protein cocrystallization. J Med Chem. 2006 Nov 30;49(24):6987-7001. DMCGI1S RU https://pubmed.ncbi.nlm.nih.gov/17125252 DMKOUCM DI DMKOUCM DMKOUCM DN 2-Fluoro-5-[5-(4-hydroxyphenyl)-2-thienyl]phenol DMKOUCM MI TTIWB6L DMKOUCM MN Estradiol 17 beta-dehydrogenase 1 (17-beta-HSD1) DMKOUCM MT DTT DMKOUCM MA Inhibitor DMKOUCM RN New insights into the SAR and binding modes of bis(hydroxyphenyl)thiophenes and -benzenes: influence of additional substituents on 17beta-hydroxyst... J Med Chem. 2009 Nov 12;52(21):6724-43. DMKOUCM RU https://pubmed.ncbi.nlm.nih.gov/19831396 DMP8OXL DI DMP8OXL DMP8OXL DN 2-Fluoro-6-(3-phenoxy-benzoylamino)-benzoic acid DMP8OXL MI TTRVTMX DMP8OXL MN Bacterial Beta-ketoacyl-ACP synthase III (Bact fabH) DMP8OXL MT DTT DMP8OXL MA Inhibitor DMP8OXL RN Structure-based design, synthesis, and study of potent inhibitors of beta-ketoacyl-acyl carrier protein synthase III as potential antimicrobial age... J Med Chem. 2005 Mar 10;48(5):1596-609. DMP8OXL RU https://pubmed.ncbi.nlm.nih.gov/15743201 DMEQRHY DI DMEQRHY DMEQRHY DN 2-fluoromevalonate 5-diphosphate DMEQRHY MI TTE5J6X DMEQRHY MN Diphosphomevalonate decarboxylase (MVD) DMEQRHY MT DTT DMEQRHY MA Inhibitor DMEQRHY RN Inhibition of mevalonate 5-diphosphate decarboxylase by fluorinated substrate analogs. Biochim Biophys Acta. 2006 Jul;1760(7):1080-7. DMEQRHY RU https://pubmed.ncbi.nlm.nih.gov/16626865 DMX34TL DI DMX34TL DMX34TL DN 2-fluoronorepinehprine DMX34TL MI TT2CJVK DMX34TL MN Adrenergic receptor beta-2 (ADRB2) DMX34TL MT DTT DMX34TL MA Inhibitor DMX34TL RN Structural basis of the selectivity of the beta(2)-adrenergic receptor for fluorinated catecholamines. Bioorg Med Chem. 2009 Dec 1;17(23):7987-92. DMX34TL RU https://pubmed.ncbi.nlm.nih.gov/19857969 DM5OW91 DI DM5OW91 DM5OW91 DN 2-fluorophenyl 1-(4-butoxyphenyl)propylcarbamate DM5OW91 MI TTDP1UC DM5OW91 MN Fatty acid amide hydrolase (FAAH) DM5OW91 MT DTT DM5OW91 MA Inhibitor DM5OW91 RN Oxime carbamate--discovery of a series of novel FAAH inhibitors. Bioorg Med Chem Lett. 2010 Feb 1;20(3):1272-7. DM5OW91 RU https://pubmed.ncbi.nlm.nih.gov/20036536 DMSFQAZ DI DMSFQAZ DMSFQAZ DN 2-fluorophenyl 4-(decyloxy)phenylcarbamate DMSFQAZ MI TTDP1UC DMSFQAZ MN Fatty acid amide hydrolase (FAAH) DMSFQAZ MT DTT DMSFQAZ MA Inhibitor DMSFQAZ RN Oxime carbamate--discovery of a series of novel FAAH inhibitors. Bioorg Med Chem Lett. 2010 Feb 1;20(3):1272-7. DMSFQAZ RU https://pubmed.ncbi.nlm.nih.gov/20036536 DMCEGZU DI DMCEGZU DMCEGZU DN 2-fluorophenyl 4-(dodecyloxy)phenylcarbamate DMCEGZU MI TTDP1UC DMCEGZU MN Fatty acid amide hydrolase (FAAH) DMCEGZU MT DTT DMCEGZU MA Inhibitor DMCEGZU RN Oxime carbamate--discovery of a series of novel FAAH inhibitors. Bioorg Med Chem Lett. 2010 Feb 1;20(3):1272-7. DMCEGZU RU https://pubmed.ncbi.nlm.nih.gov/20036536 DMLM2WU DI DMLM2WU DMLM2WU DN 2-fluorophenyl 4-(heptyloxy)phenylcarbamate DMLM2WU MI TTDP1UC DMLM2WU MN Fatty acid amide hydrolase (FAAH) DMLM2WU MT DTT DMLM2WU MA Inhibitor DMLM2WU RN Oxime carbamate--discovery of a series of novel FAAH inhibitors. Bioorg Med Chem Lett. 2010 Feb 1;20(3):1272-7. DMLM2WU RU https://pubmed.ncbi.nlm.nih.gov/20036536 DM854ED DI DM854ED DM854ED DN 2-fluorophenyl 4-(hexyloxy)phenylcarbamate DM854ED MI TTDP1UC DM854ED MN Fatty acid amide hydrolase (FAAH) DM854ED MT DTT DM854ED MA Inhibitor DM854ED RN Oxime carbamate--discovery of a series of novel FAAH inhibitors. Bioorg Med Chem Lett. 2010 Feb 1;20(3):1272-7. DM854ED RU https://pubmed.ncbi.nlm.nih.gov/20036536 DM81J0O DI DM81J0O DM81J0O DN 2-fluorophenyl 4-(octyloxy)phenylcarbamate DM81J0O MI TTDP1UC DM81J0O MN Fatty acid amide hydrolase (FAAH) DM81J0O MT DTT DM81J0O MA Inhibitor DM81J0O RN Oxime carbamate--discovery of a series of novel FAAH inhibitors. Bioorg Med Chem Lett. 2010 Feb 1;20(3):1272-7. DM81J0O RU https://pubmed.ncbi.nlm.nih.gov/20036536 DMTYX5G DI DMTYX5G DMTYX5G DN 2-fluorophenyl 4-(undecyloxy)phenylcarbamate DMTYX5G MI TTDP1UC DMTYX5G MN Fatty acid amide hydrolase (FAAH) DMTYX5G MT DTT DMTYX5G MA Inhibitor DMTYX5G RN Oxime carbamate--discovery of a series of novel FAAH inhibitors. Bioorg Med Chem Lett. 2010 Feb 1;20(3):1272-7. DMTYX5G RU https://pubmed.ncbi.nlm.nih.gov/20036536 DM4EIQ3 DI DM4EIQ3 DM4EIQ3 DN 2-fluorophenyl 4-butoxybenzylcarbamate DM4EIQ3 MI TTDP1UC DM4EIQ3 MN Fatty acid amide hydrolase (FAAH) DM4EIQ3 MT DTT DM4EIQ3 MA Inhibitor DM4EIQ3 RN Oxime carbamate--discovery of a series of novel FAAH inhibitors. Bioorg Med Chem Lett. 2010 Feb 1;20(3):1272-7. DM4EIQ3 RU https://pubmed.ncbi.nlm.nih.gov/20036536 DMYJ1M4 DI DMYJ1M4 DMYJ1M4 DN 2-fluorophenyl 4-butoxyphenylcarbamate DMYJ1M4 MI TTDP1UC DMYJ1M4 MN Fatty acid amide hydrolase (FAAH) DMYJ1M4 MT DTT DMYJ1M4 MA Inhibitor DMYJ1M4 RN Oxime carbamate--discovery of a series of novel FAAH inhibitors. Bioorg Med Chem Lett. 2010 Feb 1;20(3):1272-7. DMYJ1M4 RU https://pubmed.ncbi.nlm.nih.gov/20036536 DMGIKWA DI DMGIKWA DMGIKWA DN 2-fluorophenyl 4'-ethylbiphenyl-4-ylcarbamate DMGIKWA MI TTDP1UC DMGIKWA MN Fatty acid amide hydrolase (FAAH) DMGIKWA MT DTT DMGIKWA MA Inhibitor DMGIKWA RN Oxime carbamate--discovery of a series of novel FAAH inhibitors. Bioorg Med Chem Lett. 2010 Feb 1;20(3):1272-7. DMGIKWA RU https://pubmed.ncbi.nlm.nih.gov/20036536 DMSMDQC DI DMSMDQC DMSMDQC DN 2-fluorophenyl 4-phenoxyphenylcarbamate DMSMDQC MI TTDP1UC DMSMDQC MN Fatty acid amide hydrolase (FAAH) DMSMDQC MT DTT DMSMDQC MA Inhibitor DMSMDQC RN Oxime carbamate--discovery of a series of novel FAAH inhibitors. Bioorg Med Chem Lett. 2010 Feb 1;20(3):1272-7. DMSMDQC RU https://pubmed.ncbi.nlm.nih.gov/20036536 DMNPGXA DI DMNPGXA DMNPGXA DN 2-fluorophenyl-2,2-diphenylacetamide DMNPGXA MI TTMNI76 DMNPGXA MN Calcium-activated potassium channel (KCN) DMNPGXA MT DTT DMNPGXA MA Inhibitor DMNPGXA RN Novel inhibitors of the Gardos channel for the treatment of sickle cell disease. J Med Chem. 2008 Feb 28;51(4):976-82. DMNPGXA RU https://pubmed.ncbi.nlm.nih.gov/18232633 DMXPFYZ DI DMXPFYZ DMXPFYZ DN 2-fluorophenylboronic acid DMXPFYZ MI TTDP1UC DMXPFYZ MN Fatty acid amide hydrolase (FAAH) DMXPFYZ MT DTT DMXPFYZ MA Inhibitor DMXPFYZ RN Discovery of boronic acids as novel and potent inhibitors of fatty acid amide hydrolase. J Med Chem. 2008 Nov 27;51(22):7057-60. DMXPFYZ RU https://pubmed.ncbi.nlm.nih.gov/18983140 DM28XTE DI DM28XTE DM28XTE DN 2-Furan-2-yl-3-phenethyl-3H-quinazolin-4-one DM28XTE MI TTBUYHA DM28XTE MN Extracellular calcium-sensing receptor (CASR) DM28XTE MT DTT DM28XTE MA Inhibitor DM28XTE RN Design, new synthesis, and calcilytic activity of substituted 3H-pyrimidin-4-ones. Bioorg Med Chem Lett. 2005 May 16;15(10):2537-40. DM28XTE RU https://pubmed.ncbi.nlm.nih.gov/15863312 DMQIFJ9 DI DMQIFJ9 DMQIFJ9 DN 2-Furan-2-yl-4,5-dihydro-1H-imidazole DMQIFJ9 MI TT3WG5C DMQIFJ9 MN Monoamine oxidase type A (MAO-A) DMQIFJ9 MT DTT DMQIFJ9 MA Inhibitor DMQIFJ9 RN Binding of an imidazopyridoindole at imidazoline I2 receptors. Bioorg Med Chem Lett. 2004 Jan 19;14(2):527-9. DMQIFJ9 RU https://pubmed.ncbi.nlm.nih.gov/14698196 DMQIFJ9 DI DMQIFJ9 DMQIFJ9 DN 2-Furan-2-yl-4,5-dihydro-1H-imidazole DMQIFJ9 MI TTGP7BY DMQIFJ9 MN Monoamine oxidase type B (MAO-B) DMQIFJ9 MT DTT DMQIFJ9 MA Inhibitor DMQIFJ9 RN Binding of an imidazopyridoindole at imidazoline I2 receptors. Bioorg Med Chem Lett. 2004 Jan 19;14(2):527-9. DMQIFJ9 RU https://pubmed.ncbi.nlm.nih.gov/14698196 DMHT80R DI DMHT80R DMHT80R DN 2-Furan-2-yl-6H-pyrazolo[1,5-c]quinazolin-5-one DMHT80R MI TT1MPAY DMHT80R MN GABA(A) receptor alpha-1 (GABRA1) DMHT80R MT DTT DMHT80R MA Inhibitor DMHT80R RN Synthesis and binding activity of some pyrazolo[1,5-c]quinazolines as tools to verify an optional binding site of a benzodiazepine receptor ligand. J Med Chem. 1996 Jul 19;39(15):2915-21. DMHT80R RU https://pubmed.ncbi.nlm.nih.gov/8709126 DMHT80R DI DMHT80R DMHT80R DN 2-Furan-2-yl-6H-pyrazolo[1,5-c]quinazolin-5-one DMHT80R MI TTNJYV2 DMHT80R MN Gamma-aminobutyric acid receptor (GAR) DMHT80R MT DTT DMHT80R MA Inhibitor DMHT80R RN Synthesis and binding activity of some pyrazolo[1,5-c]quinazolines as tools to verify an optional binding site of a benzodiazepine receptor ligand. J Med Chem. 1996 Jul 19;39(15):2915-21. DMHT80R RU https://pubmed.ncbi.nlm.nih.gov/8709126 DMD8ZUH DI DMD8ZUH DMD8ZUH DN 2-Furan-2-yl-7-methyl-1H-[1,8]naphthyridin-4-one DMD8ZUH MI TTML2WA DMD8ZUH MN Tubulin (TUB) DMD8ZUH MT DTT DMD8ZUH MA Inhibitor DMD8ZUH RN Antitumor agents. 196. Substituted 2-thienyl-1,8-naphthyridin-4-ones: their synthesis, cytotoxicity, and inhibition of tubulin polymerization. J Med Chem. 1999 Oct 7;42(20):4081-7. DMD8ZUH RU https://pubmed.ncbi.nlm.nih.gov/10514278 DMD8ZUH DI DMD8ZUH DMD8ZUH DN 2-Furan-2-yl-7-methyl-1H-[1,8]naphthyridin-4-one DMD8ZUH MI TTYFKSZ DMD8ZUH MN Tubulin beta (TUBB) DMD8ZUH MT DTT DMD8ZUH MA Inhibitor DMD8ZUH RN Antitumor agents. 196. Substituted 2-thienyl-1,8-naphthyridin-4-ones: their synthesis, cytotoxicity, and inhibition of tubulin polymerization. J Med Chem. 1999 Oct 7;42(20):4081-7. DMD8ZUH RU https://pubmed.ncbi.nlm.nih.gov/10514278 DMQIRY7 DI DMQIRY7 DMQIRY7 DN 2-Furan-2-ylmethyl-1,2-dihydro-indazol-3-one DMQIRY7 MI TT2J34L DMQIRY7 MN Arachidonate 5-lipoxygenase (5-LOX) DMQIRY7 MT DTT DMQIRY7 MA Inhibitor DMQIRY7 RN Indazolinones, a new series of redox-active 5-lipoxygenase inhibitors with built-in selectivity and oral activity. J Med Chem. 1991 Mar;34(3):1028-36. DMQIRY7 RU https://pubmed.ncbi.nlm.nih.gov/1848292 DMQIRY7 DI DMQIRY7 DMQIRY7 DN 2-Furan-2-ylmethyl-1,2-dihydro-indazol-3-one DMQIRY7 MI TT8NGED DMQIRY7 MN Prostaglandin G/H synthase 1 (COX-1) DMQIRY7 MT DTT DMQIRY7 MA Inhibitor DMQIRY7 RN Indazolinones, a new series of redox-active 5-lipoxygenase inhibitors with built-in selectivity and oral activity. J Med Chem. 1991 Mar;34(3):1028-36. DMQIRY7 RU https://pubmed.ncbi.nlm.nih.gov/1848292 DMQIRY7 DI DMQIRY7 DMQIRY7 DN 2-Furan-2-ylmethyl-1,2-dihydro-indazol-3-one DMQIRY7 MI TTVKILB DMQIRY7 MN Prostaglandin G/H synthase 2 (COX-2) DMQIRY7 MT DTT DMQIRY7 MA Inhibitor DMQIRY7 RN Indazolinones, a new series of redox-active 5-lipoxygenase inhibitors with built-in selectivity and oral activity. J Med Chem. 1991 Mar;34(3):1028-36. DMQIRY7 RU https://pubmed.ncbi.nlm.nih.gov/1848292 DMET6FO DI DMET6FO DMET6FO DN 2H-chromeno[2,3-d]pyrimidine-2,4(3H)-dione DMET6FO MI TTUF2HO DMET6FO MN NAD-dependent deacetylase sirtuin-1 (SIRT1) DMET6FO MT DTT DMET6FO MA Inhibitor DMET6FO RN Characterization of sirtuin inhibitors in nematodes expressing a muscular dystrophy protein reveals muscle cell and behavioral protection by specif... J Med Chem. 2010 Feb 11;53(3):1407-11. DMET6FO RU https://pubmed.ncbi.nlm.nih.gov/20041717 DMX45WE DI DMX45WE DMX45WE DN 2-Heptyl-1(3)H-anthra[1,2-d]imidazole-6,11-dione DMX45WE MI TTQY2EJ DMX45WE MN TERT messenger RNA (TERT mRNA) DMX45WE MT DTT DMX45WE MA Inhibitor DMX45WE RN Synthesis, cytotoxicity and human telomerase inhibition activities of a series of 1,2-heteroannelated anthraquinones and anthra[1,2-d]imidazole-6,1... Bioorg Med Chem. 2009 Nov 1;17(21):7418-28. DMX45WE RU https://pubmed.ncbi.nlm.nih.gov/19804981 DMJ3ATL DI DMJ3ATL DMJ3ATL DN 2-HEPTYL-4-HYDROXY QUINOLINE N-OXIDE DMJ3ATL MI TTHDSE2 DMJ3ATL MN Bacterial Fumarate reductase flavoprotein (Bact frdA) DMJ3ATL MT DTT DMJ3ATL MA Inhibitor DMJ3ATL RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DMJ3ATL RU https://pubmed.ncbi.nlm.nih.gov/10592235 DMRXW3U DI DMRXW3U DMRXW3U DN 2-Hex-5-enyl-5-non-8-enyl-3,4-dihydro-2H-pyrrole DMRXW3U MI TT1RS9F DMRXW3U MN Acetylcholinesterase (AChE) DMRXW3U MT DTT DMRXW3U MA Inhibitor DMRXW3U RN Acetylcholinesterase inhibition by alkaloids of the ant's venom Monomorium minutum, Bioorg. Med. Chem. Lett. 5(11):1131-1132 (1995). DMRXW3U RU http://www.sciencedirect.com/science/article/pii/0960894X9500179W DM7KDQV DI DM7KDQV DM7KDQV DN 2-Hex-5-enyl-5-non-8-enyl-pyrrolidine DM7KDQV MI TT1RS9F DM7KDQV MN Acetylcholinesterase (AChE) DM7KDQV MT DTT DM7KDQV MA Inhibitor DM7KDQV RN Acetylcholinesterase inhibition by alkaloids of the ant's venom Monomorium minutum, Bioorg. Med. Chem. Lett. 5(11):1131-1132 (1995). DM7KDQV RU http://www.sciencedirect.com/science/article/pii/0960894X9500179W DMIBRYM DI DMIBRYM DMIBRYM DN 2-Hex-5-enyl-5-nonyl-pyrrolidine DMIBRYM MI TT1RS9F DMIBRYM MN Acetylcholinesterase (AChE) DMIBRYM MT DTT DMIBRYM MA Inhibitor DMIBRYM RN Acetylcholinesterase inhibition by alkaloids of the ant's venom Monomorium minutum, Bioorg. Med. Chem. Lett. 5(11):1131-1132 (1995). DMIBRYM RU http://www.sciencedirect.com/science/article/pii/0960894X9500179W DMTFIPZ DI DMTFIPZ DMTFIPZ DN 2-Hexadecynoic acid DMTFIPZ MI TTVTX4N DMTFIPZ MN Bacterial Fatty acid synthetase I (Bact inhA) DMTFIPZ MT DTT DMTFIPZ MA Inhibitor DMTFIPZ RN 2-Hexadecynoic acid inhibits plasmodial FAS-II enzymes and arrests erythrocytic and liver stage Plasmodium infections. Bioorg Med Chem. 2010 Nov 1;18(21):7475-85. DMTFIPZ RU https://pubmed.ncbi.nlm.nih.gov/20855214 DMTFIPZ DI DMTFIPZ DMTFIPZ DN 2-Hexadecynoic acid DMTFIPZ MI TT7AOUD DMTFIPZ MN Fatty acid synthase (FASN) DMTFIPZ MT DTT DMTFIPZ MA Inhibitor DMTFIPZ RN 2-Hexadecynoic acid inhibits plasmodial FAS-II enzymes and arrests erythrocytic and liver stage Plasmodium infections. Bioorg Med Chem. 2010 Nov 1;18(21):7475-85. DMTFIPZ RU https://pubmed.ncbi.nlm.nih.gov/20855214 DMTFIPZ DI DMTFIPZ DMTFIPZ DN 2-Hexadecynoic acid DMTFIPZ MI TTHPFTS DMTFIPZ MN Plasmodium Beta-hydroxyacyl-ACP dehydratase (Malaria FabZ) DMTFIPZ MT DTT DMTFIPZ MA Inhibitor DMTFIPZ RN 2-Hexadecynoic acid inhibits plasmodial FAS-II enzymes and arrests erythrocytic and liver stage Plasmodium infections. Bioorg Med Chem. 2010 Nov 1;18(21):7475-85. DMTFIPZ RU https://pubmed.ncbi.nlm.nih.gov/20855214 DMTFIPZ DI DMTFIPZ DMTFIPZ DN 2-Hexadecynoic acid DMTFIPZ MI TTBE4IR DMTFIPZ MN Plasmodium Oxoacyl-[acyl-carrier protein] reductase (Malaria fabG) DMTFIPZ MT DTT DMTFIPZ MA Inhibitor DMTFIPZ RN 2-Hexadecynoic acid inhibits plasmodial FAS-II enzymes and arrests erythrocytic and liver stage Plasmodium infections. Bioorg Med Chem. 2010 Nov 1;18(21):7475-85. DMTFIPZ RU https://pubmed.ncbi.nlm.nih.gov/20855214 DM94PBL DI DM94PBL DM94PBL DN 2-Hexyl-4-(4-isobutyl-phenyl)-1H-imidazole DM94PBL MI TTRK8B9 DM94PBL MN Sodium channel unspecific (NaC) DM94PBL MT DTT DM94PBL MA Inhibitor DM94PBL RN 2-Alkyl-4-arylimidazoles: structurally novel sodium channel modulators. Bioorg Med Chem Lett. 2004 Jul 5;14(13):3521-3. DM94PBL RU https://pubmed.ncbi.nlm.nih.gov/15177465 DM94PBL DI DM94PBL DM94PBL DN 2-Hexyl-4-(4-isobutyl-phenyl)-1H-imidazole DM94PBL MI TTAXZ0K DM94PBL MN Voltage-gated sodium channel alpha Nav1.3 (SCN3A) DM94PBL MT DTT DM94PBL MA Inhibitor DM94PBL RN 2-Alkyl-4-arylimidazoles: structurally novel sodium channel modulators. Bioorg Med Chem Lett. 2004 Jul 5;14(13):3521-3. DM94PBL RU https://pubmed.ncbi.nlm.nih.gov/15177465 DMKORTS DI DMKORTS DMKORTS DN 2-Hexyloxy-5-imidazol-1-yl-pyridine DMKORTS MI TTVG215 DMKORTS MN Debrisoquine 4-hydroxylase (CYP2D6) DMKORTS MT DTT DMKORTS MA Inhibitor DMKORTS RN Imidazole derivatives as new potent and selective 20-HETE synthase inhibitors. Bioorg Med Chem Lett. 2004 Jan 19;14(2):333-6. DMKORTS RU https://pubmed.ncbi.nlm.nih.gov/14698153 DMTD0IG DI DMTD0IG DMTD0IG DN 2-hexylphenyl acrylate DMTD0IG MI TTGER3L DMTD0IG MN Thyroid hormone receptor beta (THRB) DMTD0IG MT DTT DMTD0IG MA Inhibitor DMTD0IG RN Inhibitors of the interaction of a thyroid hormone receptor and coactivators: preliminary structure-activity relationships. J Med Chem. 2007 Nov 1;50(22):5269-80. DMTD0IG RU https://pubmed.ncbi.nlm.nih.gov/17918822 DMHR1UE DI DMHR1UE DMHR1UE DN 2H-Isoquinolin-1-one DMHR1UE MI TTVDSZ0 DMHR1UE MN Poly [ADP-ribose] polymerase 1 (PARP1) DMHR1UE MT DTT DMHR1UE MA Inhibitor DMHR1UE RN Resistance-modifying agents. 5. Synthesis and biological properties of quinazolinone inhibitors of the DNA repair enzyme poly(ADP-ribose) polymeras... J Med Chem. 1998 Dec 17;41(26):5247-56. DMHR1UE RU https://pubmed.ncbi.nlm.nih.gov/9857092 DMOT1LQ DI DMOT1LQ DMOT1LQ DN 2-Hydrazino-3-methyl-4(3H)-quinazolinone DMOT1LQ MI TTGP7BY DMOT1LQ MN Monoamine oxidase type B (MAO-B) DMOT1LQ MT DTT DMOT1LQ MA Inhibitor DMOT1LQ RN New pyrazoline bearing 4(3H)-quinazolinone inhibitors of monoamine oxidase: synthesis, biological evaluation, and structural determinants of MAO-A ... Bioorg Med Chem. 2009 Jan 15;17(2):675-89. DMOT1LQ RU https://pubmed.ncbi.nlm.nih.gov/19091581 DMG78U2 DI DMG78U2 DMG78U2 DN 2-Hydrazinocarbonyl-benzenesulfonamide DMG78U2 MI TTANPDJ DMG78U2 MN Carbonic anhydrase II (CA-II) DMG78U2 MT DTT DMG78U2 MA Inhibitor DMG78U2 RN Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/membrane-associated carbonic anhydrase isozymes I, II, and IX with sulfonamide... J Med Chem. 2005 Mar 24;48(6):2121-5. DMG78U2 RU https://pubmed.ncbi.nlm.nih.gov/15771455 DMG78U2 DI DMG78U2 DMG78U2 DN 2-Hydrazinocarbonyl-benzenesulfonamide DMG78U2 MI TT2LVK8 DMG78U2 MN Carbonic anhydrase IX (CA-IX) DMG78U2 MT DTT DMG78U2 MA Inhibitor DMG78U2 RN Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/membrane-associated carbonic anhydrase isozymes I, II, and IX with sulfonamide... J Med Chem. 2005 Mar 24;48(6):2121-5. DMG78U2 RU https://pubmed.ncbi.nlm.nih.gov/15771455 DMCNXZM DI DMCNXZM DMCNXZM DN 2-hydrazinylbenzenesulfonamide DMCNXZM MI TTUNARX DMCNXZM MN Carbonic anhydrase (CA) DMCNXZM MT DTT DMCNXZM MA Inhibitor DMCNXZM RN Cloning, expression, post-translational modifications and inhibition studies on the latest mammalian carbonic anhydrase isoform, CA XV. J Med Chem. 2009 Feb 12;52(3):646-54. DMCNXZM RU https://pubmed.ncbi.nlm.nih.gov/19193158 DMCNXZM DI DMCNXZM DMCNXZM DN 2-hydrazinylbenzenesulfonamide DMCNXZM MI TTANPDJ DMCNXZM MN Carbonic anhydrase II (CA-II) DMCNXZM MT DTT DMCNXZM MA Inhibitor DMCNXZM RN Carbonic anhydrase inhibitors. Inhibition studies of a coral secretory isoform by sulfonamides. Bioorg Med Chem. 2009 Jul 15;17(14):5054-8. DMCNXZM RU https://pubmed.ncbi.nlm.nih.gov/19520577 DMCNXZM DI DMCNXZM DMCNXZM DN 2-hydrazinylbenzenesulfonamide DMCNXZM MI TT2LVK8 DMCNXZM MN Carbonic anhydrase IX (CA-IX) DMCNXZM MT DTT DMCNXZM MA Inhibitor DMCNXZM RN Cloning, expression, post-translational modifications and inhibition studies on the latest mammalian carbonic anhydrase isoform, CA XV. J Med Chem. 2009 Feb 12;52(3):646-54. DMCNXZM RU https://pubmed.ncbi.nlm.nih.gov/19193158 DMCNXZM DI DMCNXZM DMCNXZM DN 2-hydrazinylbenzenesulfonamide DMCNXZM MI TTCFSPE DMCNXZM MN Carbonic anhydrase VI (CA-VI) DMCNXZM MT DTT DMCNXZM MA Inhibitor DMCNXZM RN Cloning, expression, post-translational modifications and inhibition studies on the latest mammalian carbonic anhydrase isoform, CA XV. J Med Chem. 2009 Feb 12;52(3):646-54. DMCNXZM RU https://pubmed.ncbi.nlm.nih.gov/19193158 DMCNXZM DI DMCNXZM DMCNXZM DN 2-hydrazinylbenzenesulfonamide DMCNXZM MI TTSYM0R DMCNXZM MN Carbonic anhydrase XII (CA-XII) DMCNXZM MT DTT DMCNXZM MA Inhibitor DMCNXZM RN Carbonic anhydrase inhibitors. Inhibition of the transmembrane isozyme XII with sulfonamides-a new target for the design of antitumor and antiglauc... Bioorg Med Chem Lett. 2005 Feb 15;15(4):963-9. DMCNXZM RU https://pubmed.ncbi.nlm.nih.gov/15686894 DMJAN52 DI DMJAN52 DMJAN52 DN 2-hydroxy capric acid DMJAN52 MI TTG0MQD DMJAN52 MN Inflammation-related GPCR EX33 (GPR84) DMJAN52 MT DTT DMJAN52 MA Agonist DMJAN52 RN Medium-chain fatty acid-sensing receptor, GPR84, is a proinflammatory receptor. J Biol Chem. 2013 Apr 12;288(15):10684-91. DMJAN52 RU https://pubmed.ncbi.nlm.nih.gov/23449982 DMM9Z0B DI DMM9Z0B DMM9Z0B DN 2-hydroxy-17beta-estradiol DMM9Z0B MI TT2QM9D DMM9Z0B MN Adenylate cyclase (ADCY) DMM9Z0B MT DTT DMM9Z0B MA Inhibitor DMM9Z0B RN Structure-based development of novel adenylyl cyclase inhibitors. J Med Chem. 2008 Aug 14;51(15):4456-64. DMM9Z0B RU https://pubmed.ncbi.nlm.nih.gov/18630896 DMM9Z0B DI DMM9Z0B DMM9Z0B DN 2-hydroxy-17beta-estradiol DMM9Z0B MI DESD26P DMM9Z0B MN UDP-glucuronosyltransferase 1A6 (UGT1A6) DMM9Z0B MT DME DMM9Z0B MA Metabolism DMM9Z0B RN Structural and functional studies of UDP-glucuronosyltransferases. Drug Metab Rev. 1999 Nov;31(4):817-99. DMM9Z0B RU https://www.ncbi.nlm.nih.gov/pubmed/?term=10575553 DM2GPF6 DI DM2GPF6 DM2GPF6 DN 2-Hydroxy-2-phenyl-nonanoic acid amide DM2GPF6 MI TTRK8B9 DM2GPF6 MN Sodium channel unspecific (NaC) DM2GPF6 MT DTT DM2GPF6 MA Inhibitor DM2GPF6 RN Comparative molecular field analysis of hydantoin binding to the neuronal voltage-dependent sodium channel. J Med Chem. 1999 May 6;42(9):1537-45. DM2GPF6 RU https://pubmed.ncbi.nlm.nih.gov/10229624 DM2GPF6 DI DM2GPF6 DM2GPF6 DN 2-Hydroxy-2-phenyl-nonanoic acid amide DM2GPF6 MI TTAXZ0K DM2GPF6 MN Voltage-gated sodium channel alpha Nav1.3 (SCN3A) DM2GPF6 MT DTT DM2GPF6 MA Inhibitor DM2GPF6 RN Comparative molecular field analysis of hydantoin binding to the neuronal voltage-dependent sodium channel. J Med Chem. 1999 May 6;42(9):1537-45. DM2GPF6 RU https://pubmed.ncbi.nlm.nih.gov/10229624 DM5ACNU DI DM5ACNU DM5ACNU DN 2'-hydroxy-3,4,5-trimethoxychalcone DM5ACNU MI TTVKILB DM5ACNU MN Prostaglandin G/H synthase 2 (COX-2) DM5ACNU MT DTT DM5ACNU MA Inhibitor DM5ACNU RN Inhibitory activity of prostaglandin E2 production by the synthetic 2'-hydroxychalcone analogues: Synthesis and SAR study. Bioorg Med Chem Lett. 2009 Mar 15;19(6):1650-3. DM5ACNU RU https://pubmed.ncbi.nlm.nih.gov/19233646 DMDOHRF DI DMDOHRF DMDOHRF DN 2-HYDROXY-3,5-DIIODOBENZOIC ACID DMDOHRF MI TTKRD0G DMDOHRF MN Endothelin A receptor (EDNRA) DMDOHRF MT DTT DMDOHRF MA Inhibitor DMDOHRF RN Allosteric inhibition of endothelin ETA receptors by 3, 5-dibromosalicylic acid. Mol Pharmacol. 2000 Dec;58(6):1461-9. DMDOHRF RU https://pubmed.ncbi.nlm.nih.gov/11093786 DMK8WUR DI DMK8WUR DMK8WUR DN 2-hydroxy-3-isopropyl-2,4,6-cycloheptatrien-1-one DMK8WUR MI TTULVH8 DMK8WUR MN Tyrosinase (TYR) DMK8WUR MT DTT DMK8WUR MA Inhibitor DMK8WUR RN Structural insights into the hot spot amino acid residues of mushroom tyrosinase for the bindings of thujaplicins. Bioorg Med Chem. 2010 Nov 15;18(22):8112-8. DMK8WUR RU https://pubmed.ncbi.nlm.nih.gov/20947360 DM5QV19 DI DM5QV19 DM5QV19 DN 2'-Hydroxy-3-methoxy-biphenyl-4-carbonitrile DM5QV19 MI TTKPW01 DM5QV19 MN Androgen receptor messenger RNA (AR mRNA) DM5QV19 MT DTT DM5QV19 MA Inhibitor DM5QV19 RN Rational design and synthesis of 4-((1R,2R)-2-hydroxycyclohexyl)-2(trifluoromethyl)benzonitrile (PF-998425), a novel, nonsteroidal androgen recepto... J Med Chem. 2008 Nov 13;51(21):7010-4. DM5QV19 RU https://pubmed.ncbi.nlm.nih.gov/18921992 DMSDYZQ DI DMSDYZQ DMSDYZQ DN 2-hydroxy-5-isopropyl-2,4,6-cycloheptatrien-1-one DMSDYZQ MI TTULVH8 DMSDYZQ MN Tyrosinase (TYR) DMSDYZQ MT DTT DMSDYZQ MA Inhibitor DMSDYZQ RN Structural insights into the hot spot amino acid residues of mushroom tyrosinase for the bindings of thujaplicins. Bioorg Med Chem. 2010 Nov 15;18(22):8112-8. DMSDYZQ RU https://pubmed.ncbi.nlm.nih.gov/20947360 DMB3Y8H DI DMB3Y8H DMB3Y8H DN 2-Hydroxy-6-(3-phenoxy-benzoylamino)-benzoic acid DMB3Y8H MI TTRVTMX DMB3Y8H MN Bacterial Beta-ketoacyl-ACP synthase III (Bact fabH) DMB3Y8H MT DTT DMB3Y8H MA Inhibitor DMB3Y8H RN Structure-based design, synthesis, and study of potent inhibitors of beta-ketoacyl-acyl carrier protein synthase III as potential antimicrobial age... J Med Chem. 2005 Mar 10;48(5):1596-609. DMB3Y8H RU https://pubmed.ncbi.nlm.nih.gov/15743201 DMOT6V7 DI DMOT6V7 DMOT6V7 DN 2-HYDROXYCARBAMOYL-4-METHYL-PENTANOIC ACID DMOT6V7 MI TTGA1IV DMOT6V7 MN Matrix metalloproteinase-8 (MMP-8) DMOT6V7 MT DTT DMOT6V7 MA Inhibitor DMOT6V7 RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DMOT6V7 RU https://pubmed.ncbi.nlm.nih.gov/10592235 DMA8DZT DI DMA8DZT DMA8DZT DN 2-Hydroxycarbamoylmethyl-pentanedioic acid DMA8DZT MI TT9G4N0 DMA8DZT MN Glutamate carboxypeptidase II (GCPII) DMA8DZT MT DTT DMA8DZT MA Inhibitor DMA8DZT RN Synthesis and biological evaluation of hydroxamate-Based inhibitors of glutamate carboxypeptidase II. Bioorg Med Chem Lett. 2003 Jul 7;13(13):2097-100. DMA8DZT RU https://pubmed.ncbi.nlm.nih.gov/12798312 DM412RI DI DM412RI DM412RI DN 2-Hydroxycarbamoyl-pentanedioic acid DM412RI MI TT9G4N0 DM412RI MN Glutamate carboxypeptidase II (GCPII) DM412RI MT DTT DM412RI MA Inhibitor DM412RI RN Synthesis and biological evaluation of hydroxamate-Based inhibitors of glutamate carboxypeptidase II. Bioorg Med Chem Lett. 2003 Jul 7;13(13):2097-100. DM412RI RU https://pubmed.ncbi.nlm.nih.gov/12798312 DM8RTBS DI DM8RTBS DM8RTBS DN 2'-Hydroxychalcone DM8RTBS MI TTVKILB DM8RTBS MN Prostaglandin G/H synthase 2 (COX-2) DM8RTBS MT DTT DM8RTBS MA Inhibitor DM8RTBS RN Inhibitory activity of prostaglandin E2 production by the synthetic 2'-hydroxychalcone analogues: Synthesis and SAR study. Bioorg Med Chem Lett. 2009 Mar 15;19(6):1650-3. DM8RTBS RU https://pubmed.ncbi.nlm.nih.gov/19233646 DM86HTZ DI DM86HTZ DM86HTZ DN 2-Hydroxycinnamic acid DM86HTZ MI TTHQPL7 DM86HTZ MN Carbonic anhydrase I (CA-I) DM86HTZ MT DTT DM86HTZ MA Inhibitor DM86HTZ RN Carbonic anhydrase inhibitors. Antioxidant polyphenols effectively inhibit mammalian isoforms I-XV. Bioorg Med Chem Lett. 2010 Sep 1;20(17):5050-3. DM86HTZ RU https://pubmed.ncbi.nlm.nih.gov/20674354 DM86HTZ DI DM86HTZ DM86HTZ DN 2-Hydroxycinnamic acid DM86HTZ MI TTANPDJ DM86HTZ MN Carbonic anhydrase II (CA-II) DM86HTZ MT DTT DM86HTZ MA Inhibitor DM86HTZ RN Carbonic anhydrase inhibitors. Antioxidant polyphenols effectively inhibit mammalian isoforms I-XV. Bioorg Med Chem Lett. 2010 Sep 1;20(17):5050-3. DM86HTZ RU https://pubmed.ncbi.nlm.nih.gov/20674354 DMT6APV DI DMT6APV DMT6APV DN 2-Hydroxyethyl 18-methoxycoronaridinate DMT6APV MI TTTVAFQ DMT6APV MN Neuronal acetylcholine receptor beta-4 (CHRNB4) DMT6APV MT DTT DMT6APV MA Inhibitor DMT6APV RN Synthesis and biological evaluation of 18-methoxycoronaridine congeners. Potential antiaddiction agents. J Med Chem. 2003 Jun 19;46(13):2716-30. DMT6APV RU https://pubmed.ncbi.nlm.nih.gov/12801235 DM5E1DC DI DM5E1DC DM5E1DC DN 2-hydroxygarveatin E DM5E1DC MI TTZJYKH DM5E1DC MN Indoleamine 2,3-dioxygenase 1 (IDO1) DM5E1DC MT DTT DM5E1DC MA Inhibitor DM5E1DC RN Indoleamine 2,3-dioxygenase inhibitors from the Northeastern Pacific Marine Hydroid Garveia annulata. J Nat Prod. 2006 Oct;69(10):1496-9. DM5E1DC RU https://pubmed.ncbi.nlm.nih.gov/17067170 DMK96BL DI DMK96BL DMK96BL DN 2-HYDROXYGARVIN A DMK96BL MI TTZJYKH DMK96BL MN Indoleamine 2,3-dioxygenase 1 (IDO1) DMK96BL MT DTT DMK96BL MA Inhibitor DMK96BL RN Indoleamine 2,3-dioxygenase inhibitors from the Northeastern Pacific Marine Hydroid Garveia annulata. J Nat Prod. 2006 Oct;69(10):1496-9. DMK96BL RU https://pubmed.ncbi.nlm.nih.gov/17067170 DMNXV2I DI DMNXV2I DMNXV2I DN 2-Hydroxyiminoolean-12-en-28-oic acid DMNXV2I MI TTZHY6R DMNXV2I MN Glycogen phosphorylase muscle form (GP) DMNXV2I MT DTT DMNXV2I MA Inhibitor DMNXV2I RN Synthesis of 3-deoxypentacyclic triterpene derivatives as inhibitors of glycogen phosphorylase. J Nat Prod. 2009 Aug;72(8):1414-8. DMNXV2I RU https://pubmed.ncbi.nlm.nih.gov/19642687 DMDKF03 DI DMDKF03 DMDKF03 DN 2-Hydroxyiminours-12-en-28-oic acid DMDKF03 MI TTZHY6R DMDKF03 MN Glycogen phosphorylase muscle form (GP) DMDKF03 MT DTT DMDKF03 MA Inhibitor DMDKF03 RN Synthesis of 3-deoxypentacyclic triterpene derivatives as inhibitors of glycogen phosphorylase. J Nat Prod. 2009 Aug;72(8):1414-8. DMDKF03 RU https://pubmed.ncbi.nlm.nih.gov/19642687 DMTLYDS DI DMTLYDS DMTLYDS DN 2-hydroxyisoquinoline-1,3(2H,4H)-dione DMTLYDS MI TT37KAF DMTLYDS MN Human immunodeficiency virus Ribonuclease H (HIV RNH) DMTLYDS MT DTT DMTLYDS MA Inhibitor DMTLYDS RN RNase H active site inhibitors of human immunodeficiency virus type 1 reverse transcriptase: design, biochemical activity, and structural information. J Med Chem. 2009 Oct 8;52(19):5781-4. DMTLYDS RU https://pubmed.ncbi.nlm.nih.gov/19791799 DMCNW3M DI DMCNW3M DMCNW3M DN 2-hydroxylauric acid DMCNW3M MI TTG0MQD DMCNW3M MN Inflammation-related GPCR EX33 (GPR84) DMCNW3M MT DTT DMCNW3M MA Agonist DMCNW3M RN Medium-chain fatty acid-sensing receptor, GPR84, is a proinflammatory receptor. J Biol Chem. 2013 Apr 12;288(15):10684-91. DMCNW3M RU https://pubmed.ncbi.nlm.nih.gov/23449982 DM4LMPD DI DM4LMPD DM4LMPD DN 2-Hydroxymethyl-3-hydroxymorphinan DM4LMPD MI TT27RFC DM4LMPD MN Opioid receptor delta (OPRD1) DM4LMPD MT DTT DM4LMPD MA Inhibitor DM4LMPD RN Synthesis and opioid receptor binding affinities of 2-substituted and 3-aminomorphinans: ligands for mu, kappa, and delta opioid receptors. J Med Chem. 2010 Jan 14;53(1):402-18. DM4LMPD RU https://pubmed.ncbi.nlm.nih.gov/19928862 DM4LMPD DI DM4LMPD DM4LMPD DN 2-Hydroxymethyl-3-hydroxymorphinan DM4LMPD MI TTQW87Y DM4LMPD MN Opioid receptor kappa (OPRK1) DM4LMPD MT DTT DM4LMPD MA Inhibitor DM4LMPD RN Synthesis and opioid receptor binding affinities of 2-substituted and 3-aminomorphinans: ligands for mu, kappa, and delta opioid receptors. J Med Chem. 2010 Jan 14;53(1):402-18. DM4LMPD RU https://pubmed.ncbi.nlm.nih.gov/19928862 DM4LMPD DI DM4LMPD DM4LMPD DN 2-Hydroxymethyl-3-hydroxymorphinan DM4LMPD MI TTKWM86 DM4LMPD MN Opioid receptor mu (MOP) DM4LMPD MT DTT DM4LMPD MA Inhibitor DM4LMPD RN Synthesis and opioid receptor binding affinities of 2-substituted and 3-aminomorphinans: ligands for mu, kappa, and delta opioid receptors. J Med Chem. 2010 Jan 14;53(1):402-18. DM4LMPD RU https://pubmed.ncbi.nlm.nih.gov/19928862 DM7MUZ1 DI DM7MUZ1 DM7MUZ1 DN 2-Hydroxymethyl-Pyrrolidine-3,4-Diol DM7MUZ1 MI TTMCF1Y DM7MUZ1 MN Purine nucleoside phosphorylase (PNP) DM7MUZ1 MT DTT DM7MUZ1 MA Inhibitor DM7MUZ1 RN DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Nucleic Acids Res. 2011 Jan;39(Database issue):D1035-41. DM7MUZ1 RU https://pubmed.ncbi.nlm.nih.gov/21059682 DMWSR13 DI DMWSR13 DMWSR13 DN 2-Hydroxy-N-(3-phenyl-propyl)-benzamide DMWSR13 MI TT64EPS DMWSR13 MN Fungal Scytalone dehydratase (Fung SDH1) DMWSR13 MT DTT DMWSR13 MA Inhibitor DMWSR13 RN A diazine heterocycle replaces a six-membered hydrogen-bonded array in the active site of scytalone dehydratase, Bioorg. Med. Chem. Lett. 3(8):1605-1608 (1993). DMWSR13 RU http://www.sciencedirect.com/science/article/pii/S0960894X00800268 DMQ0F96 DI DMQ0F96 DMQ0F96 DN 2-Hydroxy-N,6-bis(3-hydroxyphenyl)-1-naphthamide DMQ0F96 MI TTIWB6L DMQ0F96 MN Estradiol 17 beta-dehydrogenase 1 (17-beta-HSD1) DMQ0F96 MT DTT DMQ0F96 MA Inhibitor DMQ0F96 RN Substituted 6-phenyl-2-naphthols. Potent and selective nonsteroidal inhibitors of 17beta-hydroxysteroid dehydrogenase type 1 (17beta-HSD1): design,... J Med Chem. 2008 Aug 14;51(15):4685-98. DMQ0F96 RU https://pubmed.ncbi.nlm.nih.gov/18630892 DMMILJS DI DMMILJS DMMILJS DN 2-hydroxyoctanoic acid DMMILJS MI TT8WFXV DMMILJS MN Hydroxycarboxylic acid receptor 3 (HCAR3) DMMILJS MT DTT DMMILJS MA Agonist DMMILJS RN Deorphanization of GPR109B as a receptor for the beta-oxidation intermediate 3-OH-octanoic acid and its role in the regulation of lipolysis. J Biol Chem. 2009 Aug 14;284(33):21928-33. DMMILJS RU https://pubmed.ncbi.nlm.nih.gov/19561068 DMHK2NQ DI DMHK2NQ DMHK2NQ DN 2-hydroxyphenethyl 3,4,5-trihydroxybenzoate DMHK2NQ MI TTULVH8 DMHK2NQ MN Tyrosinase (TYR) DMHK2NQ MT DTT DMHK2NQ MA Inhibitor DMHK2NQ RN Synthetic tyrosyl gallate derivatives as potent melanin formation inhibitors. Bioorg Med Chem Lett. 2007 Oct 1;17(19):5462-4. DMHK2NQ RU https://pubmed.ncbi.nlm.nih.gov/17693086 DMHO8KQ DI DMHO8KQ DMHO8KQ DN 2-hydroxy-saclofen DMHO8KQ MI TTDCVZW DMHO8KQ MN Gamma-aminobutyric acid B receptor (GABBR) DMHO8KQ MT DTT DMHO8KQ MA Antagonist DMHO8KQ RN Expression cloning of GABA(B) receptors uncovers similarity to metabotropic glutamate receptors. Nature. 1997 Mar 20;386(6622):239-46. DMHO8KQ RU https://pubmed.ncbi.nlm.nih.gov/9069281 DM261B0 DI DM261B0 DM261B0 DN 2-Imidazol-1-yl-7-methoxy-3-phenyl-chromen-4-one DM261B0 MI TTSZLWK DM261B0 MN Aromatase (CYP19A1) DM261B0 MT DTT DM261B0 MA Inhibitor DM261B0 RN Synthesis and characterization of azole isoflavone inhibitors of aromatase. Bioorg Med Chem. 2005 Jun 2;13(12):4063-70. DM261B0 RU https://pubmed.ncbi.nlm.nih.gov/15911319 DM2GUDZ DI DM2GUDZ DM2GUDZ DN 2-Imidazol-1-ylmethylxanthen-9-one DM2GUDZ MI TTSZLWK DM2GUDZ MN Aromatase (CYP19A1) DM2GUDZ MT DTT DM2GUDZ MA Inhibitor DM2GUDZ RN Novel highly potent and selective nonsteroidal aromatase inhibitors: synthesis, biological evaluation and structure-activity relationships investigation. J Med Chem. 2010 Jul 22;53(14):5347-51. DM2GUDZ RU https://pubmed.ncbi.nlm.nih.gov/20568782 DMSEIUP DI DMSEIUP DMSEIUP DN 2-iodo-melatonin DMSEIUP MI TT0WAIE DMSEIUP MN Melatonin receptor type 1A (MTNR1A) DMSEIUP MT DTT DMSEIUP MA Agonist DMSEIUP RN Characterization of a retinal melatonin receptor. J Pharmacol Exp Ther. 1985 Aug;234(2):395-401. DMSEIUP RU https://pubmed.ncbi.nlm.nih.gov/2991499 DMSEIUP DI DMSEIUP DMSEIUP DN 2-iodo-melatonin DMSEIUP MI TT32JK8 DMSEIUP MN Melatonin receptor type 1B (MTNR1B) DMSEIUP MT DTT DMSEIUP MA Inhibitor DMSEIUP RN Synthesis of nitroindole derivatives with high affinity and selectivity for melatoninergic binding sites MT(3). J Med Chem. 2002 Apr 25;45(9):1853-9. DMSEIUP RU https://pubmed.ncbi.nlm.nih.gov/11960497 DMSEIUP DI DMSEIUP DMSEIUP DN 2-iodo-melatonin DMSEIUP MI TTJLP0R DMSEIUP MN Quinone reductase 2 (NQO2) DMSEIUP MT DTT DMSEIUP MA Inhibitor DMSEIUP RN Synthesis of casimiroin and optimization of its quinone reductase 2 and aromatase inhibitory activities. J Med Chem. 2009 Apr 9;52(7):1873-84. DMSEIUP RU https://pubmed.ncbi.nlm.nih.gov/19265439 DMOVRX7 DI DMOVRX7 DMOVRX7 DN 2-isooleanolic acid DMOVRX7 MI TTZHY6R DMOVRX7 MN Glycogen phosphorylase muscle form (GP) DMOVRX7 MT DTT DMOVRX7 MA Inhibitor DMOVRX7 RN Synthesis of 3-deoxypentacyclic triterpene derivatives as inhibitors of glycogen phosphorylase. J Nat Prod. 2009 Aug;72(8):1414-8. DMOVRX7 RU https://pubmed.ncbi.nlm.nih.gov/19642687 DMSLMAN DI DMSLMAN DMSLMAN DN 2-isopropyl-9H-carbazole DMSLMAN MI TTBGTCW DMSLMAN MN Kinesin spindle messenger RNA (KIF11 mRNA) DMSLMAN MT DTT DMSLMAN MA Inhibitor DMSLMAN RN Kinesin spindle protein (KSP) inhibitors with 2,3-fused indole scaffolds. J Med Chem. 2010 Jul 8;53(13):5054-8. DMSLMAN RU https://pubmed.ncbi.nlm.nih.gov/20521839 DMEZFKS DI DMEZFKS DMEZFKS DN 2-isoursolic acid DMEZFKS MI TTZHY6R DMEZFKS MN Glycogen phosphorylase muscle form (GP) DMEZFKS MT DTT DMEZFKS MA Inhibitor DMEZFKS RN Synthesis of 3-deoxypentacyclic triterpene derivatives as inhibitors of glycogen phosphorylase. J Nat Prod. 2009 Aug;72(8):1414-8. DMEZFKS RU https://pubmed.ncbi.nlm.nih.gov/19642687 DM1F4TN DI DM1F4TN DM1F4TN DN 2-Isoxazol-3-yl-3H-imidazo[4,5-c]quinoline DM1F4TN MI TT1MPAY DM1F4TN MN GABA(A) receptor alpha-1 (GABRA1) DM1F4TN MT DTT DM1F4TN MA Inhibitor DM1F4TN RN Synthesis and structure--activity relationships of fused imidazopyridines: a new series of benzodiazepine receptor ligands. J Med Chem. 1996 Jul 5;39(14):2844-51. DM1F4TN RU https://pubmed.ncbi.nlm.nih.gov/8709114 DM1F4TN DI DM1F4TN DM1F4TN DN 2-Isoxazol-3-yl-3H-imidazo[4,5-c]quinoline DM1F4TN MI TTNJYV2 DM1F4TN MN Gamma-aminobutyric acid receptor (GAR) DM1F4TN MT DTT DM1F4TN MA Inhibitor DM1F4TN RN Synthesis and structure--activity relationships of fused imidazopyridines: a new series of benzodiazepine receptor ligands. J Med Chem. 1996 Jul 5;39(14):2844-51. DM1F4TN RU https://pubmed.ncbi.nlm.nih.gov/8709114 DMD2ZNA DI DMD2ZNA DMD2ZNA DN 2-Isoxazol-5-yl-3H-imidazo[4,5-c]quinoline DMD2ZNA MI TT1MPAY DMD2ZNA MN GABA(A) receptor alpha-1 (GABRA1) DMD2ZNA MT DTT DMD2ZNA MA Inhibitor DMD2ZNA RN Synthesis and structure--activity relationships of fused imidazopyridines: a new series of benzodiazepine receptor ligands. J Med Chem. 1996 Jul 5;39(14):2844-51. DMD2ZNA RU https://pubmed.ncbi.nlm.nih.gov/8709114 DMD2ZNA DI DMD2ZNA DMD2ZNA DN 2-Isoxazol-5-yl-3H-imidazo[4,5-c]quinoline DMD2ZNA MI TTZA1NY DMD2ZNA MN GABA(A) receptor beta-2 (GABRB2) DMD2ZNA MT DTT DMD2ZNA MA Inhibitor DMD2ZNA RN Synthesis and structure--activity relationships of fused imidazopyridines: a new series of benzodiazepine receptor ligands. J Med Chem. 1996 Jul 5;39(14):2844-51. DMD2ZNA RU https://pubmed.ncbi.nlm.nih.gov/8709114 DMD2ZNA DI DMD2ZNA DMD2ZNA DN 2-Isoxazol-5-yl-3H-imidazo[4,5-c]quinoline DMD2ZNA MI TT06RH5 DMD2ZNA MN GABA(A) receptor gamma-2 (GABRG2) DMD2ZNA MT DTT DMD2ZNA MA Inhibitor DMD2ZNA RN Synthesis and structure--activity relationships of fused imidazopyridines: a new series of benzodiazepine receptor ligands. J Med Chem. 1996 Jul 5;39(14):2844-51. DMD2ZNA RU https://pubmed.ncbi.nlm.nih.gov/8709114 DMD2ZNA DI DMD2ZNA DMD2ZNA DN 2-Isoxazol-5-yl-3H-imidazo[4,5-c]quinoline DMD2ZNA MI TTNJYV2 DMD2ZNA MN Gamma-aminobutyric acid receptor (GAR) DMD2ZNA MT DTT DMD2ZNA MA Inhibitor DMD2ZNA RN Synthesis and structure--activity relationships of fused imidazopyridines: a new series of benzodiazepine receptor ligands. J Med Chem. 1996 Jul 5;39(14):2844-51. DMD2ZNA RU https://pubmed.ncbi.nlm.nih.gov/8709114 DMZD348 DI DMZD348 DMZD348 DN 2LM20-4 DMZD348 MI TTUE541 DMZD348 MN Leukocyte surface antigen Leu-16 (CD20) DMZD348 MT DTT DMZD348 MA Modulator DMZD348 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2628). DMZD348 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2628 DMPJT1C DI DMPJT1C DMPJT1C DN 2MD DMPJT1C MI TTK59TV DMPJT1C MN Vitamin D3 receptor (VDR) DMPJT1C MT DTT DMPJT1C MA Agonist DMPJT1C RN New 1alpha,25-dihydroxy-19-norvitamin D3 compounds of high biological activity: synthesis and biological evaluation of 2-hydroxymethyl, 2-methyl, and 2-methylene analogues. J Med Chem. 1998 Nov 5;41(23):4662-74. DMPJT1C RU https://pubmed.ncbi.nlm.nih.gov/9804706 DMDFPGB DI DMDFPGB DMDFPGB DN 2'-Me-CCPA DMDFPGB MI TTJFY5U DMDFPGB MN Adenosine A3 receptor (ADORA3) DMDFPGB MT DTT DMDFPGB MA Agonist DMDFPGB RN 2'-C-Methyl analogues of selective adenosine receptor agonists: synthesis and binding studies. J Med Chem. 1998 May 7;41(10):1708-15. DMDFPGB RU https://pubmed.ncbi.nlm.nih.gov/9572897 DMDZTU3 DI DMDZTU3 DMDZTU3 DN 2-MePen-RYYRIK-NH2 DMDZTU3 MI TTNT7K8 DMDZTU3 MN Nociceptin receptor (OPRL1) DMDZTU3 MT DTT DMDZTU3 MA Inhibitor DMDZTU3 RN Designed modification of partial agonist of ORL1 nociceptin receptor for conversion into highly potent antagonist. Bioorg Med Chem. 2008 Mar 1;16(5):2635-44. DMDZTU3 RU https://pubmed.ncbi.nlm.nih.gov/18068993 DMHK25N DI DMHK25N DMHK25N DN 2-Mercaptomethyl-pentanedioic acid DMHK25N MI TT9G4N0 DMHK25N MN Glutamate carboxypeptidase II (GCPII) DMHK25N MT DTT DMHK25N MA Inhibitor DMHK25N RN Synthesis and biological evaluation of thiol-based inhibitors of glutamate carboxypeptidase II: discovery of an orally active GCP II inhibitor. J Med Chem. 2003 May 8;46(10):1989-96. DMHK25N RU https://pubmed.ncbi.nlm.nih.gov/12723961 DMXEUDM DI DMXEUDM DMXEUDM DN 2-Mercapto-N-(4-sulfamoyl-phenyl)-benzamide DMXEUDM MI TTHQPL7 DMXEUDM MN Carbonic anhydrase I (CA-I) DMXEUDM MT DTT DMXEUDM MA Inhibitor DMXEUDM RN Recent developments of carbonic anhydrase inhibitors as potential anticancer drugs. J Med Chem. 2008 Jun 12;51(11):3051-6. DMXEUDM RU https://pubmed.ncbi.nlm.nih.gov/18348513 DMXEUDM DI DMXEUDM DMXEUDM DN 2-Mercapto-N-(4-sulfamoyl-phenyl)-benzamide DMXEUDM MI TTANPDJ DMXEUDM MN Carbonic anhydrase II (CA-II) DMXEUDM MT DTT DMXEUDM MA Inhibitor DMXEUDM RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DMXEUDM RU https://pubmed.ncbi.nlm.nih.gov/10592235 DMXEUDM DI DMXEUDM DMXEUDM DN 2-Mercapto-N-(4-sulfamoyl-phenyl)-benzamide DMXEUDM MI TT2LVK8 DMXEUDM MN Carbonic anhydrase IX (CA-IX) DMXEUDM MT DTT DMXEUDM MA Inhibitor DMXEUDM RN Recent developments of carbonic anhydrase inhibitors as potential anticancer drugs. J Med Chem. 2008 Jun 12;51(11):3051-6. DMXEUDM RU https://pubmed.ncbi.nlm.nih.gov/18348513 DMRVBCI DI DMRVBCI DMRVBCI DN 2-Mercapto-pentanedioic acid DMRVBCI MI TT9G4N0 DMRVBCI MN Glutamate carboxypeptidase II (GCPII) DMRVBCI MT DTT DMRVBCI MA Inhibitor DMRVBCI RN Synthesis and biological evaluation of thiol-based inhibitors of glutamate carboxypeptidase II: discovery of an orally active GCP II inhibitor. J Med Chem. 2003 May 8;46(10):1989-96. DMRVBCI RU https://pubmed.ncbi.nlm.nih.gov/12723961 DM8HSBT DI DM8HSBT DM8HSBT DN 2-mercaptophenylphosphonic acid DM8HSBT MI TTHI19T DM8HSBT MN Staphylococcus Beta-lactamase (Stap-coc blaZ) DM8HSBT MT DTT DM8HSBT MA Inhibitor DM8HSBT RN Mercaptophosphonate compounds as broad-spectrum inhibitors of the metallo-beta-lactamases. J Med Chem. 2010 Jul 8;53(13):4862-76. DM8HSBT RU https://pubmed.ncbi.nlm.nih.gov/20527888 DMGADQ1 DI DMGADQ1 DMGADQ1 DN 2MeSADP DMGADQ1 MI TTA93TL DMGADQ1 MN P2Y purinoceptor 1 (P2RY1) DMGADQ1 MT DTT DMGADQ1 MA Agonist DMGADQ1 RN Molecular cloning of the platelet P2T(AC) ADP receptor: pharmacological comparison with another ADP receptor, the P2Y(1) receptor. Mol Pharmacol. 2001 Sep;60(3):432-9. DMGADQ1 RU https://pubmed.ncbi.nlm.nih.gov/11502873 DMGADQ1 DI DMGADQ1 DMGADQ1 DN 2MeSADP DMGADQ1 MI TTZ1DT0 DMGADQ1 MN P2Y purinoceptor 12 (P2RY12) DMGADQ1 MT DTT DMGADQ1 MA Agonist DMGADQ1 RN Molecular cloning of the platelet P2T(AC) ADP receptor: pharmacological comparison with another ADP receptor, the P2Y(1) receptor. Mol Pharmacol. 2001 Sep;60(3):432-9. DMGADQ1 RU https://pubmed.ncbi.nlm.nih.gov/11502873 DMGADQ1 DI DMGADQ1 DMGADQ1 DN 2MeSADP DMGADQ1 MI TT1FE3L DMGADQ1 MN P2Y purinoceptor 13 (P2RY13) DMGADQ1 MT DTT DMGADQ1 MA Agonist DMGADQ1 RN Pharmacological characterization of the human P2Y13 receptor. Mol Pharmacol. 2003 Jul;64(1):104-12. DMGADQ1 RU https://pubmed.ncbi.nlm.nih.gov/12815166 DMBO2DC DI DMBO2DC DMBO2DC DN 2MeSAMP DMBO2DC MI TTZ1DT0 DMBO2DC MN P2Y purinoceptor 12 (P2RY12) DMBO2DC MT DTT DMBO2DC MA Antagonist DMBO2DC RN Molecular cloning of the platelet P2T(AC) ADP receptor: pharmacological comparison with another ADP receptor, the P2Y(1) receptor. Mol Pharmacol. 2001 Sep;60(3):432-9. DMBO2DC RU https://pubmed.ncbi.nlm.nih.gov/11502873 DMBO2DC DI DMBO2DC DMBO2DC DN 2MeSAMP DMBO2DC MI TT1FE3L DMBO2DC MN P2Y purinoceptor 13 (P2RY13) DMBO2DC MT DTT DMBO2DC MA Antagonist DMBO2DC RN Pharmacological characterization of the human P2Y13 receptor. Mol Pharmacol. 2003 Jul;64(1):104-12. DMBO2DC RU https://pubmed.ncbi.nlm.nih.gov/12815166 DMUE0W6 DI DMUE0W6 DMUE0W6 DN 2MeSATP DMUE0W6 MI TTA93TL DMUE0W6 MN P2Y purinoceptor 1 (P2RY1) DMUE0W6 MT DTT DMUE0W6 MA Agonist DMUE0W6 RN Quantitation of the P2Y(1) receptor with a high affinity radiolabeled antagonist. Mol Pharmacol. 2002 Nov;62(5):1249-57. DMUE0W6 RU https://pubmed.ncbi.nlm.nih.gov/12391289 DMUE0W6 DI DMUE0W6 DMUE0W6 DN 2MeSATP DMUE0W6 MI TTYXPCO DMUE0W6 MN P2Y purinoceptor 11 (P2RY11) DMUE0W6 MT DTT DMUE0W6 MA Agonist DMUE0W6 RN Pharmacological characterization of the human P2Y11 receptor. Br J Pharmacol. 1999 Nov;128(6):1199-206. DMUE0W6 RU https://pubmed.ncbi.nlm.nih.gov/10578132 DMUE0W6 DI DMUE0W6 DMUE0W6 DN 2MeSATP DMUE0W6 MI TT1FE3L DMUE0W6 MN P2Y purinoceptor 13 (P2RY13) DMUE0W6 MT DTT DMUE0W6 MA Agonist DMUE0W6 RN Pharmacological characterization of the human P2Y13 receptor. Mol Pharmacol. 2003 Jul;64(1):104-12. DMUE0W6 RU https://pubmed.ncbi.nlm.nih.gov/12815166 DMUE0W6 DI DMUE0W6 DMUE0W6 DN 2MeSATP DMUE0W6 MI TTNVSKA DMUE0W6 MN P2Y purinoceptor 6 (P2RY6) DMUE0W6 MT DTT DMUE0W6 MA Agonist DMUE0W6 RN Cloning, functional expression and tissue distribution of the human P2Y6 receptor. Biochem Biophys Res Commun. 1996 May 15;222(2):303-8. DMUE0W6 RU https://pubmed.ncbi.nlm.nih.gov/8670200 DMY2GXT DI DMY2GXT DMY2GXT DN 2'-Me-tecadenoson DMY2GXT MI TTK25J1 DMY2GXT MN Adenosine A1 receptor (ADORA1) DMY2GXT MT DTT DMY2GXT MA Inhibitor DMY2GXT RN 5'-Carbamoyl derivatives of 2'-C-methyl-purine nucleosides as selective A1 adenosine receptor agonists: affinity, efficacy, and selectivity for A1 ... Bioorg Med Chem. 2008 Jan 1;16(1):336-53. DMY2GXT RU https://pubmed.ncbi.nlm.nih.gov/17933541 DMY2GXT DI DMY2GXT DMY2GXT DN 2'-Me-tecadenoson DMY2GXT MI TTNE7KG DMY2GXT MN Adenosine A2b receptor (ADORA2B) DMY2GXT MT DTT DMY2GXT MA Inhibitor DMY2GXT RN 5'-Carbamoyl derivatives of 2'-C-methyl-purine nucleosides as selective A1 adenosine receptor agonists: affinity, efficacy, and selectivity for A1 ... Bioorg Med Chem. 2008 Jan 1;16(1):336-53. DMY2GXT RU https://pubmed.ncbi.nlm.nih.gov/17933541 DMA5Q4T DI DMA5Q4T DMA5Q4T DN 2-methoxy-1,4-naphthoquinone DMA5Q4T MI TTZJYKH DMA5Q4T MN Indoleamine 2,3-dioxygenase 1 (IDO1) DMA5Q4T MT DTT DMA5Q4T MA Inhibitor DMA5Q4T RN Indoleamine 2,3-dioxygenase is the anticancer target for a novel series of potent naphthoquinone-based inhibitors. J Med Chem. 2008 Mar 27;51(6):1706-18. DMA5Q4T RU https://pubmed.ncbi.nlm.nih.gov/18318466 DMH76C5 DI DMH76C5 DMH76C5 DN 2-methoxy-1-naphthaldehyde thiosemicarbazone DMH76C5 MI TTEAID7 DMH76C5 MN Trypanosoma Cruzipain (Trypano CYSP) DMH76C5 MT DTT DMH76C5 MA Inhibitor DMH76C5 RN Synthesis and structure-activity relationship study of potent trypanocidal thio semicarbazone inhibitors of the trypanosomal cysteine protease cruz... J Med Chem. 2002 Jun 20;45(13):2695-707. DMH76C5 RU https://pubmed.ncbi.nlm.nih.gov/12061873 DM93DYT DI DM93DYT DM93DYT DN 2-methoxy-3,4-methylenedioxybenzophenone DM93DYT MI TTMF541 DM93DYT MN Liver carboxylesterase (CES1) DM93DYT MT DTT DM93DYT MA Inhibitor DM93DYT RN Phenolic compounds from the roots of Lindera fruticosa. J Nat Prod. 2006 May;69(5):853-5. DM93DYT RU https://pubmed.ncbi.nlm.nih.gov/16724860 DMF8E5L DI DMF8E5L DMF8E5L DN 2-methoxy-4-(2-methoxyphenylthio)benzonitrile DMF8E5L MI TTKPW01 DMF8E5L MN Androgen receptor messenger RNA (AR mRNA) DMF8E5L MT DTT DMF8E5L MA Inhibitor DMF8E5L RN 4-(Alkylthio)- and 4-(arylthio)-benzonitrile derivatives as androgen receptor antagonists for the topical suppression of sebum production. Bioorg Med Chem Lett. 2009 Mar 1;19(5):1310-3. DMF8E5L RU https://pubmed.ncbi.nlm.nih.gov/19201190 DMEAVD2 DI DMEAVD2 DMEAVD2 DN 2-methoxy-4-(2-nitrovinyl)phenol DMEAVD2 MI TTGKNB4 DMEAVD2 MN Epidermal growth factor receptor (EGFR) DMEAVD2 MT DTT DMEAVD2 MA Inhibitor DMEAVD2 RN Protein-tyrosine kinase inhibition: mechanism-based discovery of antitumor agents. J Nat Prod. 1992 Nov;55(11):1529-60. DMEAVD2 RU https://pubmed.ncbi.nlm.nih.gov/1479375 DM1MGQ6 DI DM1MGQ6 DM1MGQ6 DN 2-methoxy-4-(m-tolyloxy)benzonitrile DM1MGQ6 MI TTKPW01 DM1MGQ6 MN Androgen receptor messenger RNA (AR mRNA) DM1MGQ6 MT DTT DM1MGQ6 MA Inhibitor DM1MGQ6 RN 4-(Alkylthio)- and 4-(arylthio)-benzonitrile derivatives as androgen receptor antagonists for the topical suppression of sebum production. Bioorg Med Chem Lett. 2009 Mar 1;19(5):1310-3. DM1MGQ6 RU https://pubmed.ncbi.nlm.nih.gov/19201190 DMT7YR3 DI DMT7YR3 DMT7YR3 DN 2-methoxy-4-(o-tolyloxy)benzonitrile DMT7YR3 MI TTKPW01 DMT7YR3 MN Androgen receptor messenger RNA (AR mRNA) DMT7YR3 MT DTT DMT7YR3 MA Inhibitor DMT7YR3 RN 4-(Alkylthio)- and 4-(arylthio)-benzonitrile derivatives as androgen receptor antagonists for the topical suppression of sebum production. Bioorg Med Chem Lett. 2009 Mar 1;19(5):1310-3. DMT7YR3 RU https://pubmed.ncbi.nlm.nih.gov/19201190 DMXGP2I DI DMXGP2I DMXGP2I DN 2-methoxy-4-(propylthio)benzonitrile DMXGP2I MI TTKPW01 DMXGP2I MN Androgen receptor messenger RNA (AR mRNA) DMXGP2I MT DTT DMXGP2I MA Inhibitor DMXGP2I RN 4-(Alkylthio)- and 4-(arylthio)-benzonitrile derivatives as androgen receptor antagonists for the topical suppression of sebum production. Bioorg Med Chem Lett. 2009 Mar 1;19(5):1310-3. DMXGP2I RU https://pubmed.ncbi.nlm.nih.gov/19201190 DMR5YZG DI DMR5YZG DMR5YZG DN 2-methoxy-4-(p-tolyloxy)benzonitrile DMR5YZG MI TTKPW01 DMR5YZG MN Androgen receptor messenger RNA (AR mRNA) DMR5YZG MT DTT DMR5YZG MA Inhibitor DMR5YZG RN 4-(Alkylthio)- and 4-(arylthio)-benzonitrile derivatives as androgen receptor antagonists for the topical suppression of sebum production. Bioorg Med Chem Lett. 2009 Mar 1;19(5):1310-3. DMR5YZG RU https://pubmed.ncbi.nlm.nih.gov/19201190 DMCGID6 DI DMCGID6 DMCGID6 DN 2-Methoxy-5-(3,4,5-trimethoxy-benzyl)-phenol DMCGID6 MI TTML2WA DMCGID6 MN Tubulin (TUB) DMCGID6 MT DTT DMCGID6 MA Inhibitor DMCGID6 RN Synthesis of alkoxy-substituted diaryl compounds and correlation of ring separation with inhibition of tubulin polymerization: differential enhance... J Med Chem. 1992 Mar 20;35(6):1058-67. DMCGID6 RU https://pubmed.ncbi.nlm.nih.gov/1552500 DMCGID6 DI DMCGID6 DMCGID6 DN 2-Methoxy-5-(3,4,5-trimethoxy-benzyl)-phenol DMCGID6 MI TTYFKSZ DMCGID6 MN Tubulin beta (TUBB) DMCGID6 MT DTT DMCGID6 MA Inhibitor DMCGID6 RN Synthesis of alkoxy-substituted diaryl compounds and correlation of ring separation with inhibition of tubulin polymerization: differential enhance... J Med Chem. 1992 Mar 20;35(6):1058-67. DMCGID6 RU https://pubmed.ncbi.nlm.nih.gov/1552500 DM6CAYV DI DM6CAYV DM6CAYV DN 2-Methoxy-5-(3,4,5-trimethoxy-phenoxy)-phenol DM6CAYV MI TTML2WA DM6CAYV MN Tubulin (TUB) DM6CAYV MT DTT DM6CAYV MA Inhibitor DM6CAYV RN Antimitotic and cell growth inhibitory properties of combretastatin A-4-like ethers. Bioorg Med Chem Lett. 2001 Jan 8;11(1):51-4. DM6CAYV RU https://pubmed.ncbi.nlm.nih.gov/11140732 DM6CAYV DI DM6CAYV DM6CAYV DN 2-Methoxy-5-(3,4,5-trimethoxy-phenoxy)-phenol DM6CAYV MI TTYFKSZ DM6CAYV MN Tubulin beta (TUBB) DM6CAYV MT DTT DM6CAYV MA Inhibitor DM6CAYV RN Antimitotic and cell growth inhibitory properties of combretastatin A-4-like ethers. Bioorg Med Chem Lett. 2001 Jan 8;11(1):51-4. DM6CAYV RU https://pubmed.ncbi.nlm.nih.gov/11140732 DM9LY0Z DI DM9LY0Z DM9LY0Z DN 2-Methoxy-5-(5,6,7-trimethoxy-indan-1-yl)-phenol DM9LY0Z MI TTML2WA DM9LY0Z MN Tubulin (TUB) DM9LY0Z MT DTT DM9LY0Z MA Inhibitor DM9LY0Z RN The synthesis and evaluation of temperature sensitive tubulin toxins. Bioorg Med Chem Lett. 1999 Feb 8;9(3):407-12. DM9LY0Z RU https://pubmed.ncbi.nlm.nih.gov/10091693 DM9LY0Z DI DM9LY0Z DM9LY0Z DN 2-Methoxy-5-(5,6,7-trimethoxy-indan-1-yl)-phenol DM9LY0Z MI TTYFKSZ DM9LY0Z MN Tubulin beta (TUBB) DM9LY0Z MT DTT DM9LY0Z MA Inhibitor DM9LY0Z RN The synthesis and evaluation of temperature sensitive tubulin toxins. Bioorg Med Chem Lett. 1999 Feb 8;9(3):407-12. DM9LY0Z RU https://pubmed.ncbi.nlm.nih.gov/10091693 DMXCAKO DI DMXCAKO DMXCAKO DN 2-methoxy-9-aminomethyl-9,10-dihydroanthracene DMXCAKO MI TTJQOD7 DMXCAKO MN 5-HT 2A receptor (HTR2A) DMXCAKO MT DTT DMXCAKO MA Inhibitor DMXCAKO RN Methoxy-substituted 9-aminomethyl-9,10-dihydroanthracene (AMDA) derivatives exhibit differential binding affinities at the 5-HT(2A) receptor. Bioorg Med Chem Lett. 2008 Oct 1;18(19):5268-71. DMXCAKO RU https://pubmed.ncbi.nlm.nih.gov/18774714 DM4G3FS DI DM4G3FS DM4G3FS DN 2-methoxy-alpha,beta-didehydro-agomelatine DM4G3FS MI TT0WAIE DM4G3FS MN Melatonin receptor type 1A (MTNR1A) DM4G3FS MT DTT DM4G3FS MA Agonist DM4G3FS RN Synthesis of new N-(arylcyclopropyl)acetamides and N-(arylvinyl)acetamides as conformationally-restricted ligands for melatonin receptors. Bioorg Med Chem Lett. 2013 Jan 15;23(2):430-4. DM4G3FS RU https://pubmed.ncbi.nlm.nih.gov/23265885 DMPG0V7 DI DMPG0V7 DMPG0V7 DN 2-methoxyapomorphine DMPG0V7 MI TTZFYLI DMPG0V7 MN Dopamine D1 receptor (D1R) DMPG0V7 MT DTT DMPG0V7 MA Inhibitor DMPG0V7 RN Synthesis and neuropharmacological characterization of 2-O-substituted apomorphines. Bioorg Med Chem. 2008 Apr 15;16(8):4563-8. DMPG0V7 RU https://pubmed.ncbi.nlm.nih.gov/18313931 DMPG0V7 DI DMPG0V7 DMPG0V7 DN 2-methoxyapomorphine DMPG0V7 MI TTEX248 DMPG0V7 MN Dopamine D2 receptor (D2R) DMPG0V7 MT DTT DMPG0V7 MA Inhibitor DMPG0V7 RN Synthesis and neuropharmacological characterization of 2-O-substituted apomorphines. Bioorg Med Chem. 2008 Apr 15;16(8):4563-8. DMPG0V7 RU https://pubmed.ncbi.nlm.nih.gov/18313931 DMIBKNZ DI DMIBKNZ DMIBKNZ DN 2-methoxyestradiol-17-O-sulfamate DMIBKNZ MI TTANPDJ DMIBKNZ MN Carbonic anhydrase II (CA-II) DMIBKNZ MT DTT DMIBKNZ MA Inhibitor DMIBKNZ RN Structure-activity relationships of C-17 cyano-substituted estratrienes as anticancer agents. J Med Chem. 2008 Mar 13;51(5):1295-308. DMIBKNZ RU https://pubmed.ncbi.nlm.nih.gov/18260615 DMD6L7C DI DMD6L7C DMD6L7C DN 2-methoxyestrrone-3-O-sulfamate DMD6L7C MI TTANPDJ DMD6L7C MN Carbonic anhydrase II (CA-II) DMD6L7C MT DTT DMD6L7C MA Inhibitor DMD6L7C RN Structure-activity relationships of C-17 cyano-substituted estratrienes as anticancer agents. J Med Chem. 2008 Mar 13;51(5):1295-308. DMD6L7C RU https://pubmed.ncbi.nlm.nih.gov/18260615 DM6X8GN DI DM6X8GN DM6X8GN DN 2-Methoxyethyl 18-methoxycoronaridinate DM6X8GN MI TTTVAFQ DM6X8GN MN Neuronal acetylcholine receptor beta-4 (CHRNB4) DM6X8GN MT DTT DM6X8GN MA Inhibitor DM6X8GN RN Synthesis and biological evaluation of 18-methoxycoronaridine congeners. Potential antiaddiction agents. J Med Chem. 2003 Jun 19;46(13):2716-30. DM6X8GN RU https://pubmed.ncbi.nlm.nih.gov/12801235 DM31E6J DI DM31E6J DM31E6J DN 2-Methoxy-N-(3-methyl-2-phenyl-butyl)-benzamide DM31E6J MI TTY3UE6 DM31E6J MN Voltage-gated potassium channel Kv1.3 (KCNA3) DM31E6J MT DTT DM31E6J MA Inhibitor DM31E6J RN Benzamide derivatives as blockers of Kv1.3 ion channel. Bioorg Med Chem Lett. 2003 Mar 24;13(6):1161-4. DM31E6J RU https://pubmed.ncbi.nlm.nih.gov/12643934 DMQS8VE DI DMQS8VE DMQS8VE DN 2-methoxyphenyl 10H-phenothiazine-10-carboxylate DMQS8VE MI TTEB0GD DMQS8VE MN Cholinesterase (BCHE) DMQS8VE MT DTT DMQS8VE MA Inhibitor DMQS8VE RN Carbamates with differential mechanism of inhibition toward acetylcholinesterase and butyrylcholinesterase. J Med Chem. 2008 Jul 24;51(14):4200-12. DMQS8VE RU https://pubmed.ncbi.nlm.nih.gov/18570368 DML5PE9 DI DML5PE9 DML5PE9 DN 2-methoxyphenylboronic acid DML5PE9 MI TTDP1UC DML5PE9 MN Fatty acid amide hydrolase (FAAH) DML5PE9 MT DTT DML5PE9 MA Inhibitor DML5PE9 RN Discovery of boronic acids as novel and potent inhibitors of fatty acid amide hydrolase. J Med Chem. 2008 Nov 27;51(22):7057-60. DML5PE9 RU https://pubmed.ncbi.nlm.nih.gov/18983140 DMX1IC4 DI DMX1IC4 DMX1IC4 DN 2-Methyl-[1,4]thiazepan-(5E)-ylideneamine DMX1IC4 MI TTZUFI5 DMX1IC4 MN Nitric-oxide synthase brain (NOS1) DMX1IC4 MT DTT DMX1IC4 MA Inhibitor DMX1IC4 RN Synthesis of analogs of (1,4)-3- and 5-imino oxazepane, thiazepane, and diazepane as inhibitors of nitric oxide synthases. Bioorg Med Chem Lett. 2004 Dec 6;14(23):5907-11. DMX1IC4 RU https://pubmed.ncbi.nlm.nih.gov/15501067 DMX1IC4 DI DMX1IC4 DMX1IC4 DN 2-Methyl-[1,4]thiazepan-(5E)-ylideneamine DMX1IC4 MI TTCM4B3 DMX1IC4 MN Nitric-oxide synthase endothelial (NOS3) DMX1IC4 MT DTT DMX1IC4 MA Inhibitor DMX1IC4 RN Synthesis of analogs of (1,4)-3- and 5-imino oxazepane, thiazepane, and diazepane as inhibitors of nitric oxide synthases. Bioorg Med Chem Lett. 2004 Dec 6;14(23):5907-11. DMX1IC4 RU https://pubmed.ncbi.nlm.nih.gov/15501067 DMX1IC4 DI DMX1IC4 DMX1IC4 DN 2-Methyl-[1,4]thiazepan-(5E)-ylideneamine DMX1IC4 MI TTF10I9 DMX1IC4 MN Nitric-oxide synthase inducible (NOS2) DMX1IC4 MT DTT DMX1IC4 MA Inhibitor DMX1IC4 RN Synthesis of analogs of (1,4)-3- and 5-imino oxazepane, thiazepane, and diazepane as inhibitors of nitric oxide synthases. Bioorg Med Chem Lett. 2004 Dec 6;14(23):5907-11. DMX1IC4 RU https://pubmed.ncbi.nlm.nih.gov/15501067 DMKTQB2 DI DMKTQB2 DMKTQB2 DN 2-Methyl-1(3)H-anthrasimidazole-6,11-dione DMKTQB2 MI TTQY2EJ DMKTQB2 MN TERT messenger RNA (TERT mRNA) DMKTQB2 MT DTT DMKTQB2 MA Inhibitor DMKTQB2 RN Synthesis, cytotoxicity and human telomerase inhibition activities of a series of 1,2-heteroannelated anthraquinones and anthra[1,2-d]imidazole-6,1... Bioorg Med Chem. 2009 Nov 1;17(21):7418-28. DMKTQB2 RU https://pubmed.ncbi.nlm.nih.gov/19804981 DMRWOQH DI DMRWOQH DMRWOQH DN 2-methyl-1-(pyridin-3-yl)pent-1-en-3-one oxime DMRWOQH MI TTELV3W DMRWOQH MN Transformation-sensitive protein p120 (TRPA1) DMRWOQH MT DTT DMRWOQH MA Inhibitor DMRWOQH RN Transient receptor potential ankyrin 1 (TRPA1) channel as emerging target for novel analgesics and anti-inflammatory agents. J Med Chem. 2010 Jul 22;53(14):5085-107. DMRWOQH RU https://pubmed.ncbi.nlm.nih.gov/20356305 DMTQ4FV DI DMTQ4FV DMTQ4FV DN 2-methyl-1-(pyridin-4-yl)pent-1-en-3-one oxime DMTQ4FV MI TTELV3W DMTQ4FV MN Transformation-sensitive protein p120 (TRPA1) DMTQ4FV MT DTT DMTQ4FV MA Inhibitor DMTQ4FV RN Transient receptor potential ankyrin 1 (TRPA1) channel as emerging target for novel analgesics and anti-inflammatory agents. J Med Chem. 2010 Jul 22;53(14):5085-107. DMTQ4FV RU https://pubmed.ncbi.nlm.nih.gov/20356305 DMLTJDR DI DMLTJDR DMLTJDR DN 2-methyl-1-(thiophen-2-yl)pent-1-en-3-one oxime DMLTJDR MI TTELV3W DMLTJDR MN Transformation-sensitive protein p120 (TRPA1) DMLTJDR MT DTT DMLTJDR MA Inhibitor DMLTJDR RN Transient receptor potential ankyrin 1 (TRPA1) channel as emerging target for novel analgesics and anti-inflammatory agents. J Med Chem. 2010 Jul 22;53(14):5085-107. DMLTJDR RU https://pubmed.ncbi.nlm.nih.gov/20356305 DMQJKSV DI DMQJKSV DMQJKSV DN 2-methyl-1-(thiophen-3-yl)pent-1-en-3-one oxime DMQJKSV MI TTELV3W DMQJKSV MN Transformation-sensitive protein p120 (TRPA1) DMQJKSV MT DTT DMQJKSV MA Inhibitor DMQJKSV RN Transient receptor potential ankyrin 1 (TRPA1) channel as emerging target for novel analgesics and anti-inflammatory agents. J Med Chem. 2010 Jul 22;53(14):5085-107. DMQJKSV RU https://pubmed.ncbi.nlm.nih.gov/20356305 DMDJHFQ DI DMDJHFQ DMDJHFQ DN 2-Methyl-1,2-dihydro-indazol-3-one DMDJHFQ MI TT2J34L DMDJHFQ MN Arachidonate 5-lipoxygenase (5-LOX) DMDJHFQ MT DTT DMDJHFQ MA Inhibitor DMDJHFQ RN Indazolinones, a new series of redox-active 5-lipoxygenase inhibitors with built-in selectivity and oral activity. J Med Chem. 1991 Mar;34(3):1028-36. DMDJHFQ RU https://pubmed.ncbi.nlm.nih.gov/1848292 DMDJHFQ DI DMDJHFQ DMDJHFQ DN 2-Methyl-1,2-dihydro-indazol-3-one DMDJHFQ MI TT8NGED DMDJHFQ MN Prostaglandin G/H synthase 1 (COX-1) DMDJHFQ MT DTT DMDJHFQ MA Inhibitor DMDJHFQ RN Indazolinones, a new series of redox-active 5-lipoxygenase inhibitors with built-in selectivity and oral activity. J Med Chem. 1991 Mar;34(3):1028-36. DMDJHFQ RU https://pubmed.ncbi.nlm.nih.gov/1848292 DMDJHFQ DI DMDJHFQ DMDJHFQ DN 2-Methyl-1,2-dihydro-indazol-3-one DMDJHFQ MI TTVKILB DMDJHFQ MN Prostaglandin G/H synthase 2 (COX-2) DMDJHFQ MT DTT DMDJHFQ MA Inhibitor DMDJHFQ RN Indazolinones, a new series of redox-active 5-lipoxygenase inhibitors with built-in selectivity and oral activity. J Med Chem. 1991 Mar;34(3):1028-36. DMDJHFQ RU https://pubmed.ncbi.nlm.nih.gov/1848292 DMIWX21 DI DMIWX21 DMIWX21 DN 2-Methyl-1,2-di-pyridin-3-yl-1-methoxypropane DMIWX21 MI TTIQUX7 DMIWX21 MN Steroid 11-beta-hydroxylase (CYP11B1) DMIWX21 MT DTT DMIWX21 MA Inhibitor DMIWX21 RN Structure-activity relationship study of the inhibition of adrenal cortical 11 beta-hydroxylase by new metyrapone analogues. J Med Chem. 1984 Jan;27(1):15-9. DMIWX21 RU https://pubmed.ncbi.nlm.nih.gov/6606707 DMB0NEL DI DMB0NEL DMB0NEL DN 2-Methyl-1,2-di-pyridin-3-yl-propan-1-one oxime DMB0NEL MI TTIQUX7 DMB0NEL MN Steroid 11-beta-hydroxylase (CYP11B1) DMB0NEL MT DTT DMB0NEL MA Inhibitor DMB0NEL RN Structure-activity relationship study of the inhibition of adrenal cortical 11 beta-hydroxylase by new metyrapone analogues. J Med Chem. 1984 Jan;27(1):15-9. DMB0NEL RU https://pubmed.ncbi.nlm.nih.gov/6606707 DMC3ET2 DI DMC3ET2 DMC3ET2 DN 2-Methyl-1,2-di-pyridin-3-yl-propane DMC3ET2 MI TTIQUX7 DMC3ET2 MN Steroid 11-beta-hydroxylase (CYP11B1) DMC3ET2 MT DTT DMC3ET2 MA Inhibitor DMC3ET2 RN Structure-activity relationship study of the inhibition of adrenal cortical 11 beta-hydroxylase by new metyrapone analogues. J Med Chem. 1984 Jan;27(1):15-9. DMC3ET2 RU https://pubmed.ncbi.nlm.nih.gov/6606707 DMQHM7R DI DMQHM7R DMQHM7R DN 2-Methyl-1,2-di-pyridin-3-yl-propylchloride DMQHM7R MI TTIQUX7 DMQHM7R MN Steroid 11-beta-hydroxylase (CYP11B1) DMQHM7R MT DTT DMQHM7R MA Inhibitor DMQHM7R RN Structure-activity relationship study of the inhibition of adrenal cortical 11 beta-hydroxylase by new metyrapone analogues. J Med Chem. 1984 Jan;27(1):15-9. DMQHM7R RU https://pubmed.ncbi.nlm.nih.gov/6606707 DM561MH DI DM561MH DM561MH DN 2-Methyl-1,2-di-pyridin-3-yl-propyliodide DM561MH MI TTIQUX7 DM561MH MN Steroid 11-beta-hydroxylase (CYP11B1) DM561MH MT DTT DM561MH MA Inhibitor DM561MH RN Structure-activity relationship study of the inhibition of adrenal cortical 11 beta-hydroxylase by new metyrapone analogues. J Med Chem. 1984 Jan;27(1):15-9. DM561MH RU https://pubmed.ncbi.nlm.nih.gov/6606707 DMLX9RG DI DMLX9RG DMLX9RG DN 2-Methyl-1-phenyl-2-pyridin-3-yl-propan-1-ol DMLX9RG MI TTIQUX7 DMLX9RG MN Steroid 11-beta-hydroxylase (CYP11B1) DMLX9RG MT DTT DMLX9RG MA Inhibitor DMLX9RG RN Structure-activity relationship study of the inhibition of adrenal cortical 11 beta-hydroxylase by new metyrapone analogues. J Med Chem. 1984 Jan;27(1):15-9. DMLX9RG RU https://pubmed.ncbi.nlm.nih.gov/6606707 DMZY72I DI DMZY72I DMZY72I DN 2-Methyl-1-phenyl-2-pyridin-3-yl-propan-1-one DMZY72I MI TTIQUX7 DMZY72I MN Steroid 11-beta-hydroxylase (CYP11B1) DMZY72I MT DTT DMZY72I MA Inhibitor DMZY72I RN Structure-activity relationship study of the inhibition of adrenal cortical 11 beta-hydroxylase by new metyrapone analogues. J Med Chem. 1984 Jan;27(1):15-9. DMZY72I RU https://pubmed.ncbi.nlm.nih.gov/6606707 DMD45CU DI DMD45CU DMD45CU DN 2-Methyl-2,4-Pentanediol DMD45CU MI TTC67I0 DMD45CU MN Bacterial Glucosamine-6-phosphate synthase (Bact glmS) DMD45CU MT DTT DMD45CU MA Inhibitor DMD45CU RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMD45CU RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMD45CU DI DMD45CU DMD45CU DN 2-Methyl-2,4-Pentanediol DMD45CU MI TTV3NH6 DMD45CU MN Calmodulin (CALM) DMD45CU MT DTT DMD45CU MA Inhibitor DMD45CU RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMD45CU RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMD45CU DI DMD45CU DMD45CU DN 2-Methyl-2,4-Pentanediol DMD45CU MI TTN12BZ DMD45CU MN CTP synthase (CTPS1) DMD45CU MT DTT DMD45CU MA Inhibitor DMD45CU RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMD45CU RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMD45CU DI DMD45CU DMD45CU DN 2-Methyl-2,4-Pentanediol DMD45CU MI TT5ZWB6 DMD45CU MN Dihydrodiol dehydrogenase type I (AKR1C3) DMD45CU MT DTT DMD45CU MA Inhibitor DMD45CU RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMD45CU RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMD45CU DI DMD45CU DMD45CU DN 2-Methyl-2,4-Pentanediol DMD45CU MI TT78R5H DMD45CU MN Heat shock protein 90 alpha (HSP90A) DMD45CU MT DTT DMD45CU MA Inhibitor DMD45CU RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMD45CU RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMD45CU DI DMD45CU DMD45CU DN 2-Methyl-2,4-Pentanediol DMD45CU MI TTCM4B3 DMD45CU MN Nitric-oxide synthase endothelial (NOS3) DMD45CU MT DTT DMD45CU MA Inhibitor DMD45CU RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMD45CU RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMD45CU DI DMD45CU DMD45CU DN 2-Methyl-2,4-Pentanediol DMD45CU MI TT9V5JH DMD45CU MN Phospholipase A2 (PLA2G1B) DMD45CU MT DTT DMD45CU MA Inhibitor DMD45CU RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMD45CU RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMD45CU DI DMD45CU DMD45CU DN 2-Methyl-2,4-Pentanediol DMD45CU MI TT4YO0Z DMD45CU MN Phosphopantetheine adenylyltransferase (PPAT) DMD45CU MT DTT DMD45CU MA Inhibitor DMD45CU RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMD45CU RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMD45CU DI DMD45CU DMD45CU DN 2-Methyl-2,4-Pentanediol DMD45CU MI TT48I1Y DMD45CU MN Placenta growth factor (PlGF) DMD45CU MT DTT DMD45CU MA Inhibitor DMD45CU RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMD45CU RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMD45CU DI DMD45CU DMD45CU DN 2-Methyl-2,4-Pentanediol DMD45CU MI TT9PB26 DMD45CU MN Presynaptic density protein 95 (DLG4) DMD45CU MT DTT DMD45CU MA Inhibitor DMD45CU RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMD45CU RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMD45CU DI DMD45CU DMD45CU DN 2-Methyl-2,4-Pentanediol DMD45CU MI TTE5VG0 DMD45CU MN P-selectin (SELP) DMD45CU MT DTT DMD45CU MA Inhibitor DMD45CU RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMD45CU RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMD45CU DI DMD45CU DMD45CU DN 2-Methyl-2,4-Pentanediol DMD45CU MI TTELIN2 DMD45CU MN PTPN1 messenger RNA (PTPN1 mRNA) DMD45CU MT DTT DMD45CU MA Inhibitor DMD45CU RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMD45CU RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMD45CU DI DMD45CU DMD45CU DN 2-Methyl-2,4-Pentanediol DMD45CU MI TTHI19T DMD45CU MN Staphylococcus Beta-lactamase (Stap-coc blaZ) DMD45CU MT DTT DMD45CU MA Inhibitor DMD45CU RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMD45CU RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMHM5GJ DI DMHM5GJ DMHM5GJ DN 2-Methyl-2-Propanol DMHM5GJ MI TTV3NH6 DMHM5GJ MN Calmodulin (CALM) DMHM5GJ MT DTT DMHM5GJ MA Inhibitor DMHM5GJ RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMHM5GJ RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMHM5GJ DI DMHM5GJ DMHM5GJ DN 2-Methyl-2-Propanol DMHM5GJ MI TTZL0OI DMHM5GJ MN Methionine aminopeptidase 2 (METAP2) DMHM5GJ MT DTT DMHM5GJ MA Inhibitor DMHM5GJ RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMHM5GJ RU https://pubmed.ncbi.nlm.nih.gov/17139284 DM3DNFQ DI DM3DNFQ DM3DNFQ DN 2-Methyl-3-(2-Aminothiazolo)Propanal DM3DNFQ MI TTB2MXP DM3DNFQ MN Angiotensinogenase renin (REN) DM3DNFQ MT DTT DM3DNFQ MA Inhibitor DM3DNFQ RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DM3DNFQ RU https://pubmed.ncbi.nlm.nih.gov/10592235 DMV8YIZ DI DMV8YIZ DMV8YIZ DN 2-methyl-3-(pyridin-4-yl)-1H-indol-6-amine DMV8YIZ MI TTTB4UP DMV8YIZ MN Inosine-5'-monophosphate dehydrogenase 2 (IMPDH2) DMV8YIZ MT DTT DMV8YIZ MA Inhibitor DMV8YIZ RN Low molecular weight indole fragments as IMPDH inhibitors. Bioorg Med Chem Lett. 2006 May 1;16(9):2535-8. DMV8YIZ RU https://pubmed.ncbi.nlm.nih.gov/16483769 DM8N54C DI DM8N54C DM8N54C DN 2-methyl-3-(pyridin-4-yl)-1H-indole DM8N54C MI TTTB4UP DM8N54C MN Inosine-5'-monophosphate dehydrogenase 2 (IMPDH2) DM8N54C MT DTT DM8N54C MA Inhibitor DM8N54C RN Low molecular weight indole fragments as IMPDH inhibitors. Bioorg Med Chem Lett. 2006 May 1;16(9):2535-8. DM8N54C RU https://pubmed.ncbi.nlm.nih.gov/16483769 DMHYA7G DI DMHYA7G DMHYA7G DN 2-methyl-3-phenethyl-3H-pyrimidin-4-one DMHYA7G MI TTBUYHA DMHYA7G MN Extracellular calcium-sensing receptor (CASR) DMHYA7G MT DTT DMHYA7G MA Antagonist DMHYA7G RN Design, new synthesis, and calcilytic activity of substituted 3H-pyrimidin-4-ones. Bioorg Med Chem Lett. 2005 May 16;15(10):2537-40. DMHYA7G RU https://pubmed.ncbi.nlm.nih.gov/15863312 DMAFPE7 DI DMAFPE7 DMAFPE7 DN 2-methyl-4-(2-thienylethynyl)thiazole DMAFPE7 MI TTHS256 DMAFPE7 MN Metabotropic glutamate receptor 5 (mGluR5) DMAFPE7 MT DTT DMAFPE7 MA Inhibitor DMAFPE7 RN Synthesis and structure-activity relationships of 3-[(2-methyl-1,3-thiazol-4-yl)ethynyl]pyridine analogues as potent, noncompetitive metabotropic g... J Med Chem. 2006 Feb 9;49(3):1080-100. DMAFPE7 RU https://pubmed.ncbi.nlm.nih.gov/16451073 DMK4A0J DI DMK4A0J DMK4A0J DN 2-methyl-4-(3-thienylethynyl)thiazole DMK4A0J MI TTHS256 DMK4A0J MN Metabotropic glutamate receptor 5 (mGluR5) DMK4A0J MT DTT DMK4A0J MA Inhibitor DMK4A0J RN Synthesis and structure-activity relationships of 3-[(2-methyl-1,3-thiazol-4-yl)ethynyl]pyridine analogues as potent, noncompetitive metabotropic g... J Med Chem. 2006 Feb 9;49(3):1080-100. DMK4A0J RU https://pubmed.ncbi.nlm.nih.gov/16451073 DM4P3CW DI DM4P3CW DM4P3CW DN 2-methyl-4-(m-tolylethynyl)thiazole DM4P3CW MI TTHS256 DM4P3CW MN Metabotropic glutamate receptor 5 (mGluR5) DM4P3CW MT DTT DM4P3CW MA Inhibitor DM4P3CW RN Synthesis and structure-activity relationships of 3-[(2-methyl-1,3-thiazol-4-yl)ethynyl]pyridine analogues as potent, noncompetitive metabotropic g... J Med Chem. 2006 Feb 9;49(3):1080-100. DM4P3CW RU https://pubmed.ncbi.nlm.nih.gov/16451073 DMKFBVS DI DMKFBVS DMKFBVS DN 2-Methyl-4-o-tolylethynyl-thiazole DMKFBVS MI TTHS256 DMKFBVS MN Metabotropic glutamate receptor 5 (mGluR5) DMKFBVS MT DTT DMKFBVS MA Inhibitor DMKFBVS RN 5-[(2-Methyl-1,3-thiazol-4-yl)ethynyl]-2,3'-bipyridine: a highly potent, orally active metabotropic glutamate subtype 5 (mGlu5) receptor antagonist... Bioorg Med Chem Lett. 2004 Aug 2;14(15):3993-6. DMKFBVS RU https://pubmed.ncbi.nlm.nih.gov/15225713 DMRC60A DI DMRC60A DMRC60A DN 2-Methyl-4-phenylethynyl-thiazole DMRC60A MI TTHS256 DMRC60A MN Metabotropic glutamate receptor 5 (mGluR5) DMRC60A MT DTT DMRC60A MA Inhibitor DMRC60A RN 5-[(2-Methyl-1,3-thiazol-4-yl)ethynyl]-2,3'-bipyridine: a highly potent, orally active metabotropic glutamate subtype 5 (mGlu5) receptor antagonist... Bioorg Med Chem Lett. 2004 Aug 2;14(15):3993-6. DMRC60A RU https://pubmed.ncbi.nlm.nih.gov/15225713 DMWRCFY DI DMWRCFY DMWRCFY DN 2-Methyl-4-p-tolylethynyl-thiazole DMWRCFY MI TTHS256 DMWRCFY MN Metabotropic glutamate receptor 5 (mGluR5) DMWRCFY MT DTT DMWRCFY MA Inhibitor DMWRCFY RN 5-[(2-Methyl-1,3-thiazol-4-yl)ethynyl]-2,3'-bipyridine: a highly potent, orally active metabotropic glutamate subtype 5 (mGlu5) receptor antagonist... Bioorg Med Chem Lett. 2004 Aug 2;14(15):3993-6. DMWRCFY RU https://pubmed.ncbi.nlm.nih.gov/15225713 DM1S5CB DI DM1S5CB DM1S5CB DN 2-methyl-5-HT DM1S5CB MI TTK8CXU DM1S5CB MN 5-HT 1B receptor (HTR1B) DM1S5CB MT DTT DM1S5CB MA Agonist DM1S5CB RN Human serotonin 1D receptor is encoded by a subfamily of two distinct genes: 5-HT1D alpha and 5-HT1D beta. Proc Natl Acad Sci U S A. 1992 Apr 15;89(8):3630-4. DM1S5CB RU https://pubmed.ncbi.nlm.nih.gov/1565658 DM1S5CB DI DM1S5CB DM1S5CB DN 2-methyl-5-HT DM1S5CB MI TT6MSOK DM1S5CB MN 5-HT 1D receptor (HTR1D) DM1S5CB MT DTT DM1S5CB MA Agonist DM1S5CB RN Alniditan, a new 5-hydroxytryptamine1D agonist and migraine-abortive agent: ligand-binding properties of human 5-hydroxytryptamine1D alpha, human 5-hydroxytryptamine1D beta, and calf 5-hydroxytryptamine1D receptors investigated with [3H]5-hydroxytryptamine and [3H]alniditan. Mol Pharmacol. 1996 Dec;50(6):1567-80. DM1S5CB RU https://pubmed.ncbi.nlm.nih.gov/8967979 DM1S5CB DI DM1S5CB DM1S5CB DN 2-methyl-5-HT DM1S5CB MI TTCPG9S DM1S5CB MN 5-HT 1E receptor (HTR1E) DM1S5CB MT DTT DM1S5CB MA Agonist DM1S5CB RN Cloning of another human serotonin receptor (5-HT1F): a fifth 5-HT1 receptor subtype coupled to the inhibition of adenylate cyclase. Proc Natl Acad Sci U S A. 1993 Jan 15;90(2):408-12. DM1S5CB RU https://pubmed.ncbi.nlm.nih.gov/8380639 DM1S5CB DI DM1S5CB DM1S5CB DN 2-methyl-5-HT DM1S5CB MI TT0MI3F DM1S5CB MN 5-HT 1F receptor (HTR1F) DM1S5CB MT DTT DM1S5CB MA Agonist DM1S5CB RN Cloning of another human serotonin receptor (5-HT1F): a fifth 5-HT1 receptor subtype coupled to the inhibition of adenylate cyclase. Proc Natl Acad Sci U S A. 1993 Jan 15;90(2):408-12. DM1S5CB RU https://pubmed.ncbi.nlm.nih.gov/8380639 DM1S5CB DI DM1S5CB DM1S5CB DN 2-methyl-5-HT DM1S5CB MI TT0K1SC DM1S5CB MN 5-HT 2B receptor (HTR2B) DM1S5CB MT DTT DM1S5CB MA Agonist DM1S5CB RN Pharmacological characteristics of the newly cloned rat 5-hydroxytryptamine2F receptor. Mol Pharmacol. 1993 Mar;43(3):419-26. DM1S5CB RU https://pubmed.ncbi.nlm.nih.gov/8450835 DM1S5CB DI DM1S5CB DM1S5CB DN 2-methyl-5-HT DM1S5CB MI TTPC4TU DM1S5CB MN 5-HT 3A receptor (HTR3A) DM1S5CB MT DTT DM1S5CB MA Agonist DM1S5CB RN Pharmacological profile of YM-31636, a novel 5-HT3 receptor agonist, in vitro. Eur J Pharmacol. 2000 Dec 8;409(2):195-201. DM1S5CB RU https://pubmed.ncbi.nlm.nih.gov/11104834 DM1S5CB DI DM1S5CB DM1S5CB DN 2-methyl-5-HT DM1S5CB MI TTR6K75 DM1S5CB MN 5-HT 3B receptor (HTR3B) DM1S5CB MT DTT DM1S5CB MA Agonist DM1S5CB RN The 5-HT3B subunit is a major determinant of serotonin-receptor function. Nature. 1999 Jan 28;397(6717):359-63. DM1S5CB RU https://pubmed.ncbi.nlm.nih.gov/9950429 DM1S5CB DI DM1S5CB DM1S5CB DN 2-methyl-5-HT DM1S5CB MI TTJS8PY DM1S5CB MN 5-HT 6 receptor (HTR6) DM1S5CB MT DTT DM1S5CB MA Agonist DM1S5CB RN Functional and radioligand binding characterization of rat 5-HT6 receptors stably expressed in HEK293 cells. Neuropharmacology. 1997 Apr-May;36(4-5):713-20. DM1S5CB RU https://pubmed.ncbi.nlm.nih.gov/9225298 DM536IA DI DM536IA DM536IA DN 2-methyl-6-(3-(phenylthio)prop-1-ynyl)pyridine DM536IA MI TTHS256 DM536IA MN Metabotropic glutamate receptor 5 (mGluR5) DM536IA MT DTT DM536IA MA Inhibitor DM536IA RN Structure-activity relationships for the linker in a series of pyridinyl-alkynes that are antagonists of the metabotropic glutamate receptor 5 (mGl... Bioorg Med Chem Lett. 2006 Sep 15;16(18):4788-91. DM536IA RU https://pubmed.ncbi.nlm.nih.gov/16837196 DMGPDYE DI DMGPDYE DMGPDYE DN 2-methyl-6-(3-(p-tolyloxy)prop-1-ynyl)pyridine DMGPDYE MI TTHS256 DMGPDYE MN Metabotropic glutamate receptor 5 (mGluR5) DMGPDYE MT DTT DMGPDYE MA Inhibitor DMGPDYE RN A new series of pyridinyl-alkynes as antagonists of the metabotropic glutamate receptor 5 (mGluR5). Bioorg Med Chem Lett. 2006 Sep 15;16(18):4792-5. DMGPDYE RU https://pubmed.ncbi.nlm.nih.gov/16839764 DM1YK7M DI DM1YK7M DM1YK7M DN 2-methyl-6-(4-phenylbut-1-ynyl)pyridine DM1YK7M MI TTHS256 DM1YK7M MN Metabotropic glutamate receptor 5 (mGluR5) DM1YK7M MT DTT DM1YK7M MA Inhibitor DM1YK7M RN Structure-activity relationships for the linker in a series of pyridinyl-alkynes that are antagonists of the metabotropic glutamate receptor 5 (mGl... Bioorg Med Chem Lett. 2006 Sep 15;16(18):4788-91. DM1YK7M RU https://pubmed.ncbi.nlm.nih.gov/16837196 DM0UNM1 DI DM0UNM1 DM0UNM1 DN 2-methyl-6-(4-phenylpent-1-ynyl)pyridine DM0UNM1 MI TTHS256 DM0UNM1 MN Metabotropic glutamate receptor 5 (mGluR5) DM0UNM1 MT DTT DM0UNM1 MA Inhibitor DM0UNM1 RN Structure-activity relationships for the linker in a series of pyridinyl-alkynes that are antagonists of the metabotropic glutamate receptor 5 (mGl... Bioorg Med Chem Lett. 2006 Sep 15;16(18):4788-91. DM0UNM1 RU https://pubmed.ncbi.nlm.nih.gov/16837196 DMDVO7Z DI DMDVO7Z DMDVO7Z DN 2-methyl-6-(5-phenylpent-1-ynyl)pyridine DMDVO7Z MI TTHS256 DMDVO7Z MN Metabotropic glutamate receptor 5 (mGluR5) DMDVO7Z MT DTT DMDVO7Z MA Inhibitor DMDVO7Z RN Structure-activity relationships for the linker in a series of pyridinyl-alkynes that are antagonists of the metabotropic glutamate receptor 5 (mGl... Bioorg Med Chem Lett. 2006 Sep 15;16(18):4788-91. DMDVO7Z RU https://pubmed.ncbi.nlm.nih.gov/16837196 DMVQK4Y DI DMVQK4Y DMVQK4Y DN 2-methyl-6-(phenylethynyl)pyridine DMVQK4Y MI TTVBPDM DMVQK4Y MN Metabotropic glutamate receptor 1 (mGluR1) DMVQK4Y MT DTT DMVQK4Y MA Inhibitor DMVQK4Y RN Carbamoyloximes as novel non-competitive mGlu5 receptor antagonists. Bioorg Med Chem Lett. 2010 Aug 1;20(15):4371-5. DMVQK4Y RU https://pubmed.ncbi.nlm.nih.gov/20615697 DMVQK4Y DI DMVQK4Y DMVQK4Y DN 2-methyl-6-(phenylethynyl)pyridine DMVQK4Y MI TTICZ1O DMVQK4Y MN Metabotropic glutamate receptor 4 (mGluR4) DMVQK4Y MT DTT DMVQK4Y MA Modulator (allosteric modulator) DMVQK4Y RN Positive allosteric modulation of the human metabotropic glutamate receptor 4 (hmGluR4) by SIB-1893 and MPEP. Br J Pharmacol. 2003 Mar;138(6):1026-30. DMVQK4Y RU https://pubmed.ncbi.nlm.nih.gov/12684257 DMVQK4Y DI DMVQK4Y DMVQK4Y DN 2-methyl-6-(phenylethynyl)pyridine DMVQK4Y MI TTHS256 DMVQK4Y MN Metabotropic glutamate receptor 5 (mGluR5) DMVQK4Y MT DTT DMVQK4Y MA Inhibitor DMVQK4Y RN 2-Methyl-6-(phenylethynyl)-pyridine (MPEP), a potent, selective and systemically active mGlu5 receptor antagonist. Neuropharmacology. 1999 Oct;38(10):1493-503. DMVQK4Y RU https://pubmed.ncbi.nlm.nih.gov/10530811 DMJYSF3 DI DMJYSF3 DMJYSF3 DN 2-methyl-6-(trifluoromethyl)-9H-carbazole DMJYSF3 MI TTBGTCW DMJYSF3 MN Kinesin spindle messenger RNA (KIF11 mRNA) DMJYSF3 MT DTT DMJYSF3 MA Inhibitor DMJYSF3 RN Kinesin spindle protein (KSP) inhibitors with 2,3-fused indole scaffolds. J Med Chem. 2010 Jul 8;53(13):5054-8. DMJYSF3 RU https://pubmed.ncbi.nlm.nih.gov/20521839 DM8EV4A DI DM8EV4A DM8EV4A DN 2-Methyl-6-pyrrolidin-1-yl-hex-4-ynal oxime DM8EV4A MI TTZ9SOR DM8EV4A MN Muscarinic acetylcholine receptor M1 (CHRM1) DM8EV4A MT DTT DM8EV4A MA Inhibitor DM8EV4A RN Cholinergic agents: aldehyde, ketone, and oxime analogues of the muscarinic agonist UH5, Bioorg. Med. Chem. Lett. 2(8):803-808 (1992). DM8EV4A RU http://www.sciencedirect.com/science/article/pii/S0960894X00805351 DM8EV4A DI DM8EV4A DM8EV4A DN 2-Methyl-6-pyrrolidin-1-yl-hex-4-ynal oxime DM8EV4A MI TTYEG6Q DM8EV4A MN Muscarinic acetylcholine receptor M2 (CHRM2) DM8EV4A MT DTT DM8EV4A MA Inhibitor DM8EV4A RN Cholinergic agents: aldehyde, ketone, and oxime analogues of the muscarinic agonist UH5, Bioorg. Med. Chem. Lett. 2(8):803-808 (1992). DM8EV4A RU http://www.sciencedirect.com/science/article/pii/S0960894X00805351 DM8EV4A DI DM8EV4A DM8EV4A DN 2-Methyl-6-pyrrolidin-1-yl-hex-4-ynal oxime DM8EV4A MI TTQ13Z5 DM8EV4A MN Muscarinic acetylcholine receptor M3 (CHRM3) DM8EV4A MT DTT DM8EV4A MA Inhibitor DM8EV4A RN Cholinergic agents: aldehyde, ketone, and oxime analogues of the muscarinic agonist UH5, Bioorg. Med. Chem. Lett. 2(8):803-808 (1992). DM8EV4A RU http://www.sciencedirect.com/science/article/pii/S0960894X00805351 DM8EV4A DI DM8EV4A DM8EV4A DN 2-Methyl-6-pyrrolidin-1-yl-hex-4-ynal oxime DM8EV4A MI TTQ3JTF DM8EV4A MN Muscarinic acetylcholine receptor M4 (CHRM4) DM8EV4A MT DTT DM8EV4A MA Inhibitor DM8EV4A RN Cholinergic agents: aldehyde, ketone, and oxime analogues of the muscarinic agonist UH5, Bioorg. Med. Chem. Lett. 2(8):803-808 (1992). DM8EV4A RU http://www.sciencedirect.com/science/article/pii/S0960894X00805351 DM8EV4A DI DM8EV4A DM8EV4A DN 2-Methyl-6-pyrrolidin-1-yl-hex-4-ynal oxime DM8EV4A MI TTH18TF DM8EV4A MN Muscarinic acetylcholine receptor M5 (CHRM5) DM8EV4A MT DTT DM8EV4A MA Inhibitor DM8EV4A RN Cholinergic agents: aldehyde, ketone, and oxime analogues of the muscarinic agonist UH5, Bioorg. Med. Chem. Lett. 2(8):803-808 (1992). DM8EV4A RU http://www.sciencedirect.com/science/article/pii/S0960894X00805351 DM9FZ0B DI DM9FZ0B DM9FZ0B DN 2-methyl-7-(pyridin-3-yl)quinoline DM9FZ0B MI TTHS256 DM9FZ0B MN Metabotropic glutamate receptor 5 (mGluR5) DM9FZ0B MT DTT DM9FZ0B MA Inhibitor DM9FZ0B RN Rational design of 7-arylquinolines as non-competitive metabotropic glutamate receptor subtype 5 antagonists. Bioorg Med Chem Lett. 2007 Aug 15;17(16):4415-8. DM9FZ0B RU https://pubmed.ncbi.nlm.nih.gov/17590335 DMMFKOH DI DMMFKOH DMMFKOH DN 2-methyl-7-m-tolyl-1,6-naphthyridine DMMFKOH MI TTHS256 DMMFKOH MN Metabotropic glutamate receptor 5 (mGluR5) DMMFKOH MT DTT DMMFKOH MA Inhibitor DMMFKOH RN Synthesis and SAR comparison of regioisomeric aryl naphthyridines as potent mGlu5 receptor antagonists. Bioorg Med Chem Lett. 2007 Dec 1;17(23):6525-8. DMMFKOH RU https://pubmed.ncbi.nlm.nih.gov/17936624 DMZFK4R DI DMZFK4R DMZFK4R DN 2-methyl-7-m-tolyl-1,8-naphthyridine DMZFK4R MI TTHS256 DMZFK4R MN Metabotropic glutamate receptor 5 (mGluR5) DMZFK4R MT DTT DMZFK4R MA Inhibitor DMZFK4R RN Synthesis and SAR comparison of regioisomeric aryl naphthyridines as potent mGlu5 receptor antagonists. Bioorg Med Chem Lett. 2007 Dec 1;17(23):6525-8. DMZFK4R RU https://pubmed.ncbi.nlm.nih.gov/17936624 DMC02TI DI DMC02TI DMC02TI DN 2-methyl-7-m-tolylquinoline DMC02TI MI TTHS256 DMC02TI MN Metabotropic glutamate receptor 5 (mGluR5) DMC02TI MT DTT DMC02TI MA Inhibitor DMC02TI RN Rational design of 7-arylquinolines as non-competitive metabotropic glutamate receptor subtype 5 antagonists. Bioorg Med Chem Lett. 2007 Aug 15;17(16):4415-8. DMC02TI RU https://pubmed.ncbi.nlm.nih.gov/17590335 DM8RV5X DI DM8RV5X DM8RV5X DN 2-methyl-7-phenyl-1,8-naphthyridine DM8RV5X MI TTHS256 DM8RV5X MN Metabotropic glutamate receptor 5 (mGluR5) DM8RV5X MT DTT DM8RV5X MA Inhibitor DM8RV5X RN Synthesis and SAR comparison of regioisomeric aryl naphthyridines as potent mGlu5 receptor antagonists. Bioorg Med Chem Lett. 2007 Dec 1;17(23):6525-8. DM8RV5X RU https://pubmed.ncbi.nlm.nih.gov/17936624 DMT7MVD DI DMT7MVD DMT7MVD DN 2-methyl-7-phenylquinoline DMT7MVD MI TTHS256 DMT7MVD MN Metabotropic glutamate receptor 5 (mGluR5) DMT7MVD MT DTT DMT7MVD MA Inhibitor DMT7MVD RN Rational design of 7-arylquinolines as non-competitive metabotropic glutamate receptor subtype 5 antagonists. Bioorg Med Chem Lett. 2007 Aug 15;17(16):4415-8. DMT7MVD RU https://pubmed.ncbi.nlm.nih.gov/17590335 DMY65CX DI DMY65CX DMY65CX DN 2-Methyl-8-phenyl-1,2,3,4-tetrahydro-isoquinoline DMY65CX MI TTZFYLI DMY65CX MN Dopamine D1 receptor (D1R) DMY65CX MT DTT DMY65CX MA Inhibitor DMY65CX RN Synthesis and evaluation of 1,2,3,4-tetrahydro[1]benzothieno[2,3-h]isoquinolines as dopamine antagonists. J Med Chem. 1981 Sep;24(9):1107-10. DMY65CX RU https://pubmed.ncbi.nlm.nih.gov/7288826 DMY65CX DI DMY65CX DMY65CX DN 2-Methyl-8-phenyl-1,2,3,4-tetrahydro-isoquinoline DMY65CX MI TTEX248 DMY65CX MN Dopamine D2 receptor (D2R) DMY65CX MT DTT DMY65CX MA Inhibitor DMY65CX RN Synthesis and evaluation of 1,2,3,4-tetrahydro[1]benzothieno[2,3-h]isoquinolines as dopamine antagonists. J Med Chem. 1981 Sep;24(9):1107-10. DMY65CX RU https://pubmed.ncbi.nlm.nih.gov/7288826 DM06TZN DI DM06TZN DM06TZN DN 2-methyl-9H-carbazole DM06TZN MI TTBGTCW DM06TZN MN Kinesin spindle messenger RNA (KIF11 mRNA) DM06TZN MT DTT DM06TZN MA Inhibitor DM06TZN RN Kinesin spindle protein (KSP) inhibitors with 2,3-fused indole scaffolds. J Med Chem. 2010 Jul 8;53(13):5054-8. DM06TZN RU https://pubmed.ncbi.nlm.nih.gov/20521839 DMEVFJW DI DMEVFJW DMEVFJW DN 2-methyl-9H-indeno[2,1-d]pyrimidin-9-one DMEVFJW MI TTGP7BY DMEVFJW MN Monoamine oxidase type B (MAO-B) DMEVFJW MT DTT DMEVFJW MA Inhibitor DMEVFJW RN Synthesis and monoamine oxidase inhibitory activity of new pyridazine-, pyrimidine- and 1,2,4-triazine-containing tricyclic derivatives. J Med Chem. 2007 Nov 1;50(22):5364-71. DMEVFJW RU https://pubmed.ncbi.nlm.nih.gov/17910428 DMKP6BM DI DMKP6BM DMKP6BM DN 2-Methylamino-succinic acid(NMDA) DMKP6BM MI TTLD29N DMKP6BM MN Glutamate receptor ionotropic NMDA 1 (NMDAR1) DMKP6BM MT DTT DMKP6BM MA Inhibitor DMKP6BM RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 455). DMKP6BM RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=455 DMKP6BM DI DMKP6BM DMKP6BM DN 2-Methylamino-succinic acid(NMDA) DMKP6BM MI TTKJEMQ DMKP6BM MN Glutamate receptor ionotropic NMDA 2A (NMDAR2A) DMKP6BM MT DTT DMKP6BM MA Inhibitor DMKP6BM RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 456). DMKP6BM RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=456 DMKP6BM DI DMKP6BM DMKP6BM DN 2-Methylamino-succinic acid(NMDA) DMKP6BM MI TTN9D8E DMKP6BM MN Glutamate receptor ionotropic NMDA 2B (NMDAR2B) DMKP6BM MT DTT DMKP6BM MA Inhibitor DMKP6BM RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 457). DMKP6BM RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=457 DMKP6BM DI DMKP6BM DMKP6BM DN 2-Methylamino-succinic acid(NMDA) DMKP6BM MI TT1M8OW DMKP6BM MN Glutamate receptor ionotropic NMDA 2C (GluN2C) DMKP6BM MT DTT DMKP6BM MA Agonist DMKP6BM RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 458). DMKP6BM RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=458 DMKP6BM DI DMKP6BM DMKP6BM DN 2-Methylamino-succinic acid(NMDA) DMKP6BM MI TT5POTG DMKP6BM MN Glutamate receptor ionotropic NMDA 2D (GluN2D) DMKP6BM MT DTT DMKP6BM MA Agonist DMKP6BM RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 459). DMKP6BM RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=459 DMQBF7J DI DMQBF7J DMQBF7J DN 2-Methyl-beta-carboline-2-ium iodide DMQBF7J MI TTEB0GD DMQBF7J MN Cholinesterase (BCHE) DMQBF7J MT DTT DMQBF7J MA Inhibitor DMQBF7J RN Bivalent beta-carbolines as potential multitarget anti-Alzheimer agents. J Med Chem. 2010 May 13;53(9):3611-7. DMQBF7J RU https://pubmed.ncbi.nlm.nih.gov/20361801 DMKB2P8 DI DMKB2P8 DMKB2P8 DN 2-methylbut-3-yn-2-yl 4-methoxybenzoate DMKB2P8 MI TTPLTSQ DMKB2P8 MN Neutrophil elastase (NE) DMKB2P8 MT DTT DMKB2P8 MA Inhibitor DMKB2P8 RN N-benzoylpyrazoles are novel small-molecule inhibitors of human neutrophil elastase. J Med Chem. 2007 Oct 4;50(20):4928-38. DMKB2P8 RU https://pubmed.ncbi.nlm.nih.gov/17850059 DMD8CQS DI DMD8CQS DMD8CQS DN 2-methylhistamine DMD8CQS MI TTXJ178 DMD8CQS MN Histamine H4 receptor (H4R) DMD8CQS MT DTT DMD8CQS MA Agonist DMD8CQS RN Compared pharmacology of human histamine H3 and H4 receptors: structure-activity relationships of histamine derivatives. Br J Pharmacol. 2006 Apr;147(7):744-54. DMD8CQS RU https://pubmed.ncbi.nlm.nih.gov/16432504 DMHW9GL DI DMHW9GL DMHW9GL DN 2-methylisoquinoline-1,3,4-trione DMHW9GL MI TTPF2QI DMHW9GL MN Caspase-3 (CASP3) DMHW9GL MT DTT DMHW9GL MA Inhibitor DMHW9GL RN Design, synthesis, and biological evaluation of isoquinoline-1,3,4-trione derivatives as potent caspase-3 inhibitors. J Med Chem. 2006 Mar 9;49(5):1613-23. DMHW9GL RU https://pubmed.ncbi.nlm.nih.gov/16509578 DMUN3LV DI DMUN3LV DMUN3LV DN 2-Methylquinoline-8-carboxamide DMUN3LV MI TTVDSZ0 DMUN3LV MN Poly [ADP-ribose] polymerase 1 (PARP1) DMUN3LV MT DTT DMUN3LV MA Inhibitor DMUN3LV RN Design, synthesis, and evaluation in vitro of quinoline-8-carboxamides, a new class of poly(adenosine-diphosphate-ribose)polymerase-1 (PARP-1) inhi... J Med Chem. 2009 Feb 12;52(3):868-77. DMUN3LV RU https://pubmed.ncbi.nlm.nih.gov/19117416 DMM4HXK DI DMM4HXK DMM4HXK DN 2-methylsulfanylestradiol 3,17-O,O-bis-sulfamate DMM4HXK MI TTHM0R1 DMM4HXK MN Steryl-sulfatase (STS) DMM4HXK MT DTT DMM4HXK MA Inhibitor DMM4HXK RN 2-substituted estradiol bis-sulfamates, multitargeted antitumor agents: synthesis, in vitro SAR, protein crystallography, and in vivo activity. J Med Chem. 2006 Dec 28;49(26):7683-96. DMM4HXK RU https://pubmed.ncbi.nlm.nih.gov/17181151 DM4IJXW DI DM4IJXW DM4IJXW DN 2-MOE phosphorothioate gapmers DM4IJXW MI TTZQTY2 DM4IJXW MN DMPK messenger RNA (DMPK mRNA) DM4IJXW MT DTT DM4IJXW RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1505). DM4IJXW RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1505 DME9S8M DI DME9S8M DME9S8M DN 2'-Monophosphoadenosine 5'-Diphosphoribose DME9S8M MI TTFBNVI DME9S8M MN Aldose reductase (AKR1B1) DME9S8M MT DTT DME9S8M MA Inhibitor DME9S8M RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DME9S8M RU https://pubmed.ncbi.nlm.nih.gov/17139284 DME9S8M DI DME9S8M DME9S8M DN 2'-Monophosphoadenosine 5'-Diphosphoribose DME9S8M MI TTQWGU9 DME9S8M MN Bacterial Aspartate-semialdehyde dehydrogenase (Bact asd2) DME9S8M MT DTT DME9S8M MA Inhibitor DME9S8M RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DME9S8M RU https://pubmed.ncbi.nlm.nih.gov/17139284 DME9S8M DI DME9S8M DME9S8M DN 2'-Monophosphoadenosine 5'-Diphosphoribose DME9S8M MI TTN7BL9 DME9S8M MN Corticosteroid 11-beta-dehydrogenase 1 (HSD11B1) DME9S8M MT DTT DME9S8M MA Inhibitor DME9S8M RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DME9S8M RU https://pubmed.ncbi.nlm.nih.gov/17139284 DME9S8M DI DME9S8M DME9S8M DN 2'-Monophosphoadenosine 5'-Diphosphoribose DME9S8M MI TT5ZWB6 DME9S8M MN Dihydrodiol dehydrogenase type I (AKR1C3) DME9S8M MT DTT DME9S8M MA Inhibitor DME9S8M RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DME9S8M RU https://pubmed.ncbi.nlm.nih.gov/17139284 DME9S8M DI DME9S8M DME9S8M DN 2'-Monophosphoadenosine 5'-Diphosphoribose DME9S8M MI TTJS7O4 DME9S8M MN Entamoeba Alcohol dehydrogenase 2 (Entamo ADH2) DME9S8M MT DTT DME9S8M MA Inhibitor DME9S8M RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DME9S8M RU https://pubmed.ncbi.nlm.nih.gov/17139284 DME9S8M DI DME9S8M DME9S8M DN 2'-Monophosphoadenosine 5'-Diphosphoribose DME9S8M MI TTIWB6L DME9S8M MN Estradiol 17 beta-dehydrogenase 1 (17-beta-HSD1) DME9S8M MT DTT DME9S8M MA Inhibitor DME9S8M RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DME9S8M RU https://pubmed.ncbi.nlm.nih.gov/17139284 DME9S8M DI DME9S8M DME9S8M DN 2'-Monophosphoadenosine 5'-Diphosphoribose DME9S8M MI TTKN8W0 DME9S8M MN Glucose-6-phosphate dehydrogenase (G6PD) DME9S8M MT DTT DME9S8M MA Inhibitor DME9S8M RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DME9S8M RU https://pubmed.ncbi.nlm.nih.gov/17139284 DME9S8M DI DME9S8M DME9S8M DN 2'-Monophosphoadenosine 5'-Diphosphoribose DME9S8M MI TTPADOQ DME9S8M MN HMG-CoA reductase (HMGCR) DME9S8M MT DTT DME9S8M MA Inhibitor DME9S8M RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DME9S8M RU https://pubmed.ncbi.nlm.nih.gov/17139284 DME9S8M DI DME9S8M DME9S8M DN 2'-Monophosphoadenosine 5'-Diphosphoribose DME9S8M MI TTZUFI5 DME9S8M MN Nitric-oxide synthase brain (NOS1) DME9S8M MT DTT DME9S8M MA Inhibitor DME9S8M RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DME9S8M RU https://pubmed.ncbi.nlm.nih.gov/17139284 DME9S8M DI DME9S8M DME9S8M DN 2'-Monophosphoadenosine 5'-Diphosphoribose DME9S8M MI TT9SL3Q DME9S8M MN Polypeptide deformylase (PDF) DME9S8M MT DTT DME9S8M MA Inhibitor DME9S8M RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DME9S8M RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMDYRNF DI DMDYRNF DMDYRNF DN 2'-Monophosphoadenosine-5'-Diphosphate DMDYRNF MI TT9SL3Q DMDYRNF MN Polypeptide deformylase (PDF) DMDYRNF MT DTT DMDYRNF MA Inhibitor DMDYRNF RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMDYRNF RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMCVF7R DI DMCVF7R DMCVF7R DN 2-morpholin-4-yl-6-phenyl-4H-thiopyran-4-one DMCVF7R MI TTK3PY9 DMCVF7R MN DNA-dependent protein kinase catalytic (PRKDC) DMCVF7R MT DTT DMCVF7R MA Inhibitor DMCVF7R RN Pyranone, thiopyranone, and pyridone inhibitors of phosphatidylinositol 3-kinase related kinases. Structure-activity relationships for DNA-dependen... J Med Chem. 2007 Apr 19;50(8):1958-72. DMCVF7R RU https://pubmed.ncbi.nlm.nih.gov/17371003 DMTB1KV DI DMTB1KV DMTB1KV DN 2-Morpholin-4-yl-6-phenyl-chromen-4-one DMTB1KV MI TTK3PY9 DMTB1KV MN DNA-dependent protein kinase catalytic (PRKDC) DMTB1KV MT DTT DMTB1KV MA Inhibitor DMTB1KV RN Selective benzopyranone and pyrimido[2,1-a]isoquinolin-4-one inhibitors of DNA-dependent protein kinase: synthesis, structure-activity studies, and... J Med Chem. 2005 Jan 27;48(2):569-85. DMTB1KV RU https://pubmed.ncbi.nlm.nih.gov/15658870 DMC1TWI DI DMC1TWI DMC1TWI DN 2-morpholin-4-yl-8-naphthalen-2-ylchromen-4-one DMC1TWI MI TTK3PY9 DMC1TWI MN DNA-dependent protein kinase catalytic (PRKDC) DMC1TWI MT DTT DMC1TWI MA Inhibitor DMC1TWI RN Discovery of potent chromen-4-one inhibitors of the DNA-dependent protein kinase (DNA-PK) using a small-molecule library approach. J Med Chem. 2005 Dec 1;48(24):7829-46. DMC1TWI RU https://pubmed.ncbi.nlm.nih.gov/16302822 DMVN38H DI DMVN38H DMVN38H DN 2-morpholin-4-yl-8-phenoxathiin-4-ylchromen-4-one DMVN38H MI TTK3PY9 DMVN38H MN DNA-dependent protein kinase catalytic (PRKDC) DMVN38H MT DTT DMVN38H MA Inhibitor DMVN38H RN Discovery of potent chromen-4-one inhibitors of the DNA-dependent protein kinase (DNA-PK) using a small-molecule library approach. J Med Chem. 2005 Dec 1;48(24):7829-46. DMVN38H RU https://pubmed.ncbi.nlm.nih.gov/16302822 DMNKHOI DI DMNKHOI DMNKHOI DN 2-Morpholin-4-yl-8-phenylethynyl-chromen-4-one DMNKHOI MI TTJGW1Z DMNKHOI MN Phosphodiesterase 2A (PDE2A) DMNKHOI MT DTT DMNKHOI MA Inhibitor DMNKHOI RN PDE2 inhibition by the PI3 kinase inhibitor LY294002 and analogues. Bioorg Med Chem Lett. 2004 Jun 7;14(11):2847-51. DMNKHOI RU https://pubmed.ncbi.nlm.nih.gov/15125945 DMNKHOI DI DMNKHOI DMNKHOI DN 2-Morpholin-4-yl-8-phenylethynyl-chromen-4-one DMNKHOI MI TT06AWU DMNKHOI MN Phosphodiesterase 3A (PDE3A) DMNKHOI MT DTT DMNKHOI MA Inhibitor DMNKHOI RN Analysis of anti-PDE3 activity of 2-morpholinochromone derivatives reveals multiple mechanisms of anti-platelet activity. Bioorg Med Chem Lett. 2006 Feb 15;16(4):969-73. DMNKHOI RU https://pubmed.ncbi.nlm.nih.gov/16290931 DMNHYQ0 DI DMNHYQ0 DMNHYQ0 DN 2-morpholin-4-yl-8-styrylchromen-4-one DMNHYQ0 MI TTK3PY9 DMNHYQ0 MN DNA-dependent protein kinase catalytic (PRKDC) DMNHYQ0 MT DTT DMNHYQ0 MA Inhibitor DMNHYQ0 RN Discovery of potent chromen-4-one inhibitors of the DNA-dependent protein kinase (DNA-PK) using a small-molecule library approach. J Med Chem. 2005 Dec 1;48(24):7829-46. DMNHYQ0 RU https://pubmed.ncbi.nlm.nih.gov/16302822 DM5JHT6 DI DM5JHT6 DM5JHT6 DN 2-morpholin-4-yl-8-thiophen-2-ylchromen-4-one DM5JHT6 MI TTK3PY9 DM5JHT6 MN DNA-dependent protein kinase catalytic (PRKDC) DM5JHT6 MT DTT DM5JHT6 MA Inhibitor DM5JHT6 RN Discovery of potent chromen-4-one inhibitors of the DNA-dependent protein kinase (DNA-PK) using a small-molecule library approach. J Med Chem. 2005 Dec 1;48(24):7829-46. DM5JHT6 RU https://pubmed.ncbi.nlm.nih.gov/16302822 DMCY4EP DI DMCY4EP DMCY4EP DN 2-morpholin-4-yl-8-thiophen-3-ylchromen-4-one DMCY4EP MI TTK3PY9 DMCY4EP MN DNA-dependent protein kinase catalytic (PRKDC) DMCY4EP MT DTT DMCY4EP MA Inhibitor DMCY4EP RN Discovery of potent chromen-4-one inhibitors of the DNA-dependent protein kinase (DNA-PK) using a small-molecule library approach. J Med Chem. 2005 Dec 1;48(24):7829-46. DMCY4EP RU https://pubmed.ncbi.nlm.nih.gov/16302822 DM3ZWNI DI DM3ZWNI DM3ZWNI DN 2-Morpholin-4-yl-benzo[h]chromene-4-thione DM3ZWNI MI TTK3PY9 DM3ZWNI MN DNA-dependent protein kinase catalytic (PRKDC) DM3ZWNI MT DTT DM3ZWNI MA Inhibitor DM3ZWNI RN Selective benzopyranone and pyrimido[2,1-a]isoquinolin-4-one inhibitors of DNA-dependent protein kinase: synthesis, structure-activity studies, and... J Med Chem. 2005 Jan 27;48(2):569-85. DM3ZWNI RU https://pubmed.ncbi.nlm.nih.gov/15658870 DMDTRZ2 DI DMDTRZ2 DMDTRZ2 DN 2-Morpholin-4-yl-N-(4-sulfamoyl-phenyl)-acetamide DMDTRZ2 MI TTHQPL7 DMDTRZ2 MN Carbonic anhydrase I (CA-I) DMDTRZ2 MT DTT DMDTRZ2 MA Inhibitor DMDTRZ2 RN Carbonic anhydrase inhibitors. Novel sulfanilamide/acetazolamide derivatives obtained by the tail approach and their interaction with the cytosolic... Bioorg Med Chem Lett. 2005 Jan 17;15(2):367-72. DMDTRZ2 RU https://pubmed.ncbi.nlm.nih.gov/15603956 DMDTRZ2 DI DMDTRZ2 DMDTRZ2 DN 2-Morpholin-4-yl-N-(4-sulfamoyl-phenyl)-acetamide DMDTRZ2 MI TTANPDJ DMDTRZ2 MN Carbonic anhydrase II (CA-II) DMDTRZ2 MT DTT DMDTRZ2 MA Inhibitor DMDTRZ2 RN Carbonic anhydrase inhibitors. Novel sulfanilamide/acetazolamide derivatives obtained by the tail approach and their interaction with the cytosolic... Bioorg Med Chem Lett. 2005 Jan 17;15(2):367-72. DMDTRZ2 RU https://pubmed.ncbi.nlm.nih.gov/15603956 DMDTRZ2 DI DMDTRZ2 DMDTRZ2 DN 2-Morpholin-4-yl-N-(4-sulfamoyl-phenyl)-acetamide DMDTRZ2 MI TT2LVK8 DMDTRZ2 MN Carbonic anhydrase IX (CA-IX) DMDTRZ2 MT DTT DMDTRZ2 MA Inhibitor DMDTRZ2 RN Carbonic anhydrase inhibitors. Novel sulfanilamide/acetazolamide derivatives obtained by the tail approach and their interaction with the cytosolic... Bioorg Med Chem Lett. 2005 Jan 17;15(2):367-72. DMDTRZ2 RU https://pubmed.ncbi.nlm.nih.gov/15603956 DMCKSX7 DI DMCKSX7 DMCKSX7 DN 2-Morpholin-4-yl-pyrido[1,2-a]pyrimidin-4-one DMCKSX7 MI TTK3PY9 DMCKSX7 MN DNA-dependent protein kinase catalytic (PRKDC) DMCKSX7 MT DTT DMCKSX7 MA Inhibitor DMCKSX7 RN Selective benzopyranone and pyrimido[2,1-a]isoquinolin-4-one inhibitors of DNA-dependent protein kinase: synthesis, structure-activity studies, and... J Med Chem. 2005 Jan 27;48(2):569-85. DMCKSX7 RU https://pubmed.ncbi.nlm.nih.gov/15658870 DM79ZOV DI DM79ZOV DM79ZOV DN 2-Morpholin-4-yl-pyrimido[2,1-a]isoquinolin-4-one DM79ZOV MI TTK3PY9 DM79ZOV MN DNA-dependent protein kinase catalytic (PRKDC) DM79ZOV MT DTT DM79ZOV MA Inhibitor DM79ZOV RN Selective benzopyranone and pyrimido[2,1-a]isoquinolin-4-one inhibitors of DNA-dependent protein kinase: synthesis, structure-activity studies, and... J Med Chem. 2005 Jan 27;48(2):569-85. DM79ZOV RU https://pubmed.ncbi.nlm.nih.gov/15658870 DM79ZOV DI DM79ZOV DM79ZOV DN 2-Morpholin-4-yl-pyrimido[2,1-a]isoquinolin-4-one DM79ZOV MI TTCJG29 DM79ZOV MN Serine/threonine-protein kinase mTOR (mTOR) DM79ZOV MT DTT DM79ZOV MA Inhibitor DM79ZOV RN Selective benzopyranone and pyrimido[2,1-a]isoquinolin-4-one inhibitors of DNA-dependent protein kinase: synthesis, structure-activity studies, and... J Med Chem. 2005 Jan 27;48(2):569-85. DM79ZOV RU https://pubmed.ncbi.nlm.nih.gov/15658870 DMFHTEG DI DMFHTEG DMFHTEG DN 2-morpholino-1,1,2-triphenylethanol DMFHTEG MI TTW0CMT DMFHTEG MN Voltage-gated potassium channel Kv1.5 (KCNA5) DMFHTEG MT DTT DMFHTEG MA Inhibitor DMFHTEG RN Discovery of triarylethanolamine inhibitors of the Kv1.5 potassium channel. Bioorg Med Chem Lett. 2010 Apr 15;20(8):2493-6. DMFHTEG RU https://pubmed.ncbi.nlm.nih.gov/20304642 DMH89O5 DI DMH89O5 DMH89O5 DN 2-morpholino-1,1-di(pyridin-3-yl)hexan-1-ol DMH89O5 MI TTW0CMT DMH89O5 MN Voltage-gated potassium channel Kv1.5 (KCNA5) DMH89O5 MT DTT DMH89O5 MA Inhibitor DMH89O5 RN Discovery of triarylethanolamine inhibitors of the Kv1.5 potassium channel. Bioorg Med Chem Lett. 2010 Apr 15;20(8):2493-6. DMH89O5 RU https://pubmed.ncbi.nlm.nih.gov/20304642 DMDMVA1 DI DMDMVA1 DMDMVA1 DN 2-morpholino-1,1-di(pyridin-3-yl)octan-1-ol DMDMVA1 MI TTW0CMT DMDMVA1 MN Voltage-gated potassium channel Kv1.5 (KCNA5) DMDMVA1 MT DTT DMDMVA1 MA Inhibitor DMDMVA1 RN Discovery of triarylethanolamine inhibitors of the Kv1.5 potassium channel. Bioorg Med Chem Lett. 2010 Apr 15;20(8):2493-6. DMDMVA1 RU https://pubmed.ncbi.nlm.nih.gov/20304642 DM3V5AB DI DM3V5AB DM3V5AB DN 2-morpholino-2-phenyl-1,1-di(pyridin-3-yl)ethanol DM3V5AB MI TTW0CMT DM3V5AB MN Voltage-gated potassium channel Kv1.5 (KCNA5) DM3V5AB MT DTT DM3V5AB MA Inhibitor DM3V5AB RN Discovery of triarylethanolamine inhibitors of the Kv1.5 potassium channel. Bioorg Med Chem Lett. 2010 Apr 15;20(8):2493-6. DM3V5AB RU https://pubmed.ncbi.nlm.nih.gov/20304642 DM5J6IT DI DM5J6IT DM5J6IT DN 2-morpholino-4H-benzo[g]chromen-4-one DM5J6IT MI TTK3PY9 DM5J6IT MN DNA-dependent protein kinase catalytic (PRKDC) DM5J6IT MT DTT DM5J6IT MA Inhibitor DM5J6IT RN Discovery of potent chromen-4-one inhibitors of the DNA-dependent protein kinase (DNA-PK) using a small-molecule library approach. J Med Chem. 2005 Dec 1;48(24):7829-46. DM5J6IT RU https://pubmed.ncbi.nlm.nih.gov/16302822 DMZL6Q1 DI DMZL6Q1 DMZL6Q1 DN 2-morpholino-6-(naphthalen-1-yl)-4H-chromen-4-one DMZL6Q1 MI TTK3PY9 DMZL6Q1 MN DNA-dependent protein kinase catalytic (PRKDC) DMZL6Q1 MT DTT DMZL6Q1 MA Inhibitor DMZL6Q1 RN Discovery of potent chromen-4-one inhibitors of the DNA-dependent protein kinase (DNA-PK) using a small-molecule library approach. J Med Chem. 2005 Dec 1;48(24):7829-46. DMZL6Q1 RU https://pubmed.ncbi.nlm.nih.gov/16302822 DMEOI0V DI DMEOI0V DMEOI0V DN 2-morpholino-6-(naphthalen-1-yl)-4H-pyran-4-one DMEOI0V MI TTK3PY9 DMEOI0V MN DNA-dependent protein kinase catalytic (PRKDC) DMEOI0V MT DTT DMEOI0V MA Inhibitor DMEOI0V RN Pyranone, thiopyranone, and pyridone inhibitors of phosphatidylinositol 3-kinase related kinases. Structure-activity relationships for DNA-dependen... J Med Chem. 2007 Apr 19;50(8):1958-72. DMEOI0V RU https://pubmed.ncbi.nlm.nih.gov/17371003 DMO7QCN DI DMO7QCN DMO7QCN DN 2-morpholino-6-(naphthalen-2-yl)-4H-pyran-4-one DMO7QCN MI TTK3PY9 DMO7QCN MN DNA-dependent protein kinase catalytic (PRKDC) DMO7QCN MT DTT DMO7QCN MA Inhibitor DMO7QCN RN Pyranone, thiopyranone, and pyridone inhibitors of phosphatidylinositol 3-kinase related kinases. Structure-activity relationships for DNA-dependen... J Med Chem. 2007 Apr 19;50(8):1958-72. DMO7QCN RU https://pubmed.ncbi.nlm.nih.gov/17371003 DMTBRLK DI DMTBRLK DMTBRLK DN 2-morpholino-6-(quinolin-8-yl)-4H-pyran-4-one DMTBRLK MI TTK3PY9 DMTBRLK MN DNA-dependent protein kinase catalytic (PRKDC) DMTBRLK MT DTT DMTBRLK MA Inhibitor DMTBRLK RN Pyranone, thiopyranone, and pyridone inhibitors of phosphatidylinositol 3-kinase related kinases. Structure-activity relationships for DNA-dependen... J Med Chem. 2007 Apr 19;50(8):1958-72. DMTBRLK RU https://pubmed.ncbi.nlm.nih.gov/17371003 DMATVZB DI DMATVZB DMATVZB DN 2-morpholino-6-(thianthren-1-yl)-4H-chromen-4-one DMATVZB MI TTK3PY9 DMATVZB MN DNA-dependent protein kinase catalytic (PRKDC) DMATVZB MT DTT DMATVZB MA Inhibitor DMATVZB RN Discovery of potent chromen-4-one inhibitors of the DNA-dependent protein kinase (DNA-PK) using a small-molecule library approach. J Med Chem. 2005 Dec 1;48(24):7829-46. DMATVZB RU https://pubmed.ncbi.nlm.nih.gov/16302822 DMTWJMN DI DMTWJMN DMTWJMN DN 2-morpholino-6-(thiophen-2-yl)-4H-pyran-4-one DMTWJMN MI TTK3PY9 DMTWJMN MN DNA-dependent protein kinase catalytic (PRKDC) DMTWJMN MT DTT DMTWJMN MA Inhibitor DMTWJMN RN Pyranone, thiopyranone, and pyridone inhibitors of phosphatidylinositol 3-kinase related kinases. Structure-activity relationships for DNA-dependen... J Med Chem. 2007 Apr 19;50(8):1958-72. DMTWJMN RU https://pubmed.ncbi.nlm.nih.gov/17371003 DMF3NPW DI DMF3NPW DMF3NPW DN 2-morpholino-6-(thiophen-3-yl)-4H-pyran-4-one DMF3NPW MI TTK3PY9 DMF3NPW MN DNA-dependent protein kinase catalytic (PRKDC) DMF3NPW MT DTT DMF3NPW MA Inhibitor DMF3NPW RN Pyranone, thiopyranone, and pyridone inhibitors of phosphatidylinositol 3-kinase related kinases. Structure-activity relationships for DNA-dependen... J Med Chem. 2007 Apr 19;50(8):1958-72. DMF3NPW RU https://pubmed.ncbi.nlm.nih.gov/17371003 DMMC0ZP DI DMMC0ZP DMMC0ZP DN 2-morpholino-6-phenyl-4H-pyran-4-one DMMC0ZP MI TTK3PY9 DMMC0ZP MN DNA-dependent protein kinase catalytic (PRKDC) DMMC0ZP MT DTT DMMC0ZP MA Inhibitor DMMC0ZP RN Pyranone, thiopyranone, and pyridone inhibitors of phosphatidylinositol 3-kinase related kinases. Structure-activity relationships for DNA-dependen... J Med Chem. 2007 Apr 19;50(8):1958-72. DMMC0ZP RU https://pubmed.ncbi.nlm.nih.gov/17371003 DM8ZPJI DI DM8ZPJI DM8ZPJI DN 2-morpholino-6-styryl-4H-pyran-4-one DM8ZPJI MI TTK3PY9 DM8ZPJI MN DNA-dependent protein kinase catalytic (PRKDC) DM8ZPJI MT DTT DM8ZPJI MA Inhibitor DM8ZPJI RN Pyranone, thiopyranone, and pyridone inhibitors of phosphatidylinositol 3-kinase related kinases. Structure-activity relationships for DNA-dependen... J Med Chem. 2007 Apr 19;50(8):1958-72. DM8ZPJI RU https://pubmed.ncbi.nlm.nih.gov/17371003 DM4XKYN DI DM4XKYN DM4XKYN DN 2-morpholino-7-(2-phenylethynyl)-4H-chromen-4-one DM4XKYN MI TT06AWU DM4XKYN MN Phosphodiesterase 3A (PDE3A) DM4XKYN MT DTT DM4XKYN MA Inhibitor DM4XKYN RN Analysis of anti-PDE3 activity of 2-morpholinochromone derivatives reveals multiple mechanisms of anti-platelet activity. Bioorg Med Chem Lett. 2006 Feb 15;16(4):969-73. DM4XKYN RU https://pubmed.ncbi.nlm.nih.gov/16290931 DMK7WON DI DMK7WON DMK7WON DN 2-morpholino-7-phenyl-4H-chromen-4-one DMK7WON MI TT06AWU DMK7WON MN Phosphodiesterase 3A (PDE3A) DMK7WON MT DTT DMK7WON MA Inhibitor DMK7WON RN Analysis of anti-PDE3 activity of 2-morpholinochromone derivatives reveals multiple mechanisms of anti-platelet activity. Bioorg Med Chem Lett. 2006 Feb 15;16(4):969-73. DMK7WON RU https://pubmed.ncbi.nlm.nih.gov/16290931 DMYP0UI DI DMYP0UI DMYP0UI DN 2-morpholinobenzo[h]quinolin-4(1H)-one DMYP0UI MI TTK3PY9 DMYP0UI MN DNA-dependent protein kinase catalytic (PRKDC) DMYP0UI MT DTT DMYP0UI MA Inhibitor DMYP0UI RN Discovery of potent chromen-4-one inhibitors of the DNA-dependent protein kinase (DNA-PK) using a small-molecule library approach. J Med Chem. 2005 Dec 1;48(24):7829-46. DMYP0UI RU https://pubmed.ncbi.nlm.nih.gov/16302822 DMIQYWM DI DMIQYWM DMIQYWM DN 2-morpholino-N-phenethylpyrimidin-4-amine DMIQYWM MI TT1RS9F DMIQYWM MN Acetylcholinesterase (AChE) DMIQYWM MT DTT DMIQYWM MA Inhibitor DMIQYWM RN Design, synthesis and evaluation of 2,4-disubstituted pyrimidines as cholinesterase inhibitors. Bioorg Med Chem Lett. 2010 Jun 15;20(12):3606-9. DMIQYWM RU https://pubmed.ncbi.nlm.nih.gov/20472431 DMBWDXH DI DMBWDXH DMBWDXH DN 2-m-tolyl-1,8-naphthyridine DMBWDXH MI TTHS256 DMBWDXH MN Metabotropic glutamate receptor 5 (mGluR5) DMBWDXH MT DTT DMBWDXH MA Inhibitor DMBWDXH RN Synthesis and SAR comparison of regioisomeric aryl naphthyridines as potent mGlu5 receptor antagonists. Bioorg Med Chem Lett. 2007 Dec 1;17(23):6525-8. DMBWDXH RU https://pubmed.ncbi.nlm.nih.gov/17936624 DM9ZVHJ DI DM9ZVHJ DM9ZVHJ DN 2-m-Tolyl-1H-[1,8]naphthyridin-4-one DM9ZVHJ MI TTML2WA DM9ZVHJ MN Tubulin (TUB) DM9ZVHJ MT DTT DM9ZVHJ MA Inhibitor DM9ZVHJ RN Antitumor agents. 178. Synthesis and biological evaluation of substituted 2-aryl-1,8-naphthyridin-4(1H)-ones as antitumor agents that inhibit tubul... J Med Chem. 1997 Sep 12;40(19):3049-56. DM9ZVHJ RU https://pubmed.ncbi.nlm.nih.gov/9301667 DM9ZVHJ DI DM9ZVHJ DM9ZVHJ DN 2-m-Tolyl-1H-[1,8]naphthyridin-4-one DM9ZVHJ MI TTYFKSZ DM9ZVHJ MN Tubulin beta (TUBB) DM9ZVHJ MT DTT DM9ZVHJ MA Inhibitor DM9ZVHJ RN Antitumor agents. 178. Synthesis and biological evaluation of substituted 2-aryl-1,8-naphthyridin-4(1H)-ones as antitumor agents that inhibit tubul... J Med Chem. 1997 Sep 12;40(19):3049-56. DM9ZVHJ RU https://pubmed.ncbi.nlm.nih.gov/9301667 DM3AFXM DI DM3AFXM DM3AFXM DN 2-m-tolyl-2H-pyrazolo[3,4-c]quinolin-4(5H)-one DM3AFXM MI TTK25J1 DM3AFXM MN Adenosine A1 receptor (ADORA1) DM3AFXM MT DTT DM3AFXM MA Inhibitor DM3AFXM RN New 2-arylpyrazolo[3,4-c]quinoline derivatives as potent and selective human A3 adenosine receptor antagonists. Synthesis, pharmacological evaluati... J Med Chem. 2007 Aug 23;50(17):4061-74. DM3AFXM RU https://pubmed.ncbi.nlm.nih.gov/17665891 DMIMRCH DI DMIMRCH DMIMRCH DN 2-m-tolyl-2H-pyrazolo[3,4-c]quinolin-4-amine DMIMRCH MI TTK25J1 DMIMRCH MN Adenosine A1 receptor (ADORA1) DMIMRCH MT DTT DMIMRCH MA Inhibitor DMIMRCH RN New 2-arylpyrazolo[3,4-c]quinoline derivatives as potent and selective human A3 adenosine receptor antagonists. Synthesis, pharmacological evaluati... J Med Chem. 2007 Aug 23;50(17):4061-74. DMIMRCH RU https://pubmed.ncbi.nlm.nih.gov/17665891 DMIMRCH DI DMIMRCH DMIMRCH DN 2-m-tolyl-2H-pyrazolo[3,4-c]quinolin-4-amine DMIMRCH MI TTM2AOE DMIMRCH MN Adenosine A2a receptor (ADORA2A) DMIMRCH MT DTT DMIMRCH MA Inhibitor DMIMRCH RN New 2-arylpyrazolo[3,4-c]quinoline derivatives as potent and selective human A3 adenosine receptor antagonists. Synthesis, pharmacological evaluati... J Med Chem. 2007 Aug 23;50(17):4061-74. DMIMRCH RU https://pubmed.ncbi.nlm.nih.gov/17665891 DM0PT8R DI DM0PT8R DM0PT8R DN 2-N-(Isopropyl)amino-1-(4-methylthiophenyl)butane DM0PT8R MI TT3ROYC DM0PT8R MN Serotonin transporter (SERT) DM0PT8R MT DTT DM0PT8R MA Inhibitor DM0PT8R RN Synthesis and serotonin transporter activity of sulphur-substituted alpha-alkyl phenethylamines as a new class of anticancer agents. Eur J Med Chem. 2009 Dec;44(12):4862-88. DM0PT8R RU https://pubmed.ncbi.nlm.nih.gov/19717215 DMLJ30O DI DMLJ30O DMLJ30O DN 2-N-(n-Propyl)amino-1-(4-methylthiophenyl)butane DMLJ30O MI TT3ROYC DMLJ30O MN Serotonin transporter (SERT) DMLJ30O MT DTT DMLJ30O MA Inhibitor DMLJ30O RN Synthesis and serotonin transporter activity of sulphur-substituted alpha-alkyl phenethylamines as a new class of anticancer agents. Eur J Med Chem. 2009 Dec;44(12):4862-88. DMLJ30O RU https://pubmed.ncbi.nlm.nih.gov/19717215 DMKSUVH DI DMKSUVH DMKSUVH DN 2-N,N-Dimethylamino-1-(4-methylthiophenyl)propane DMKSUVH MI TT3ROYC DMKSUVH MN Serotonin transporter (SERT) DMKSUVH MT DTT DMKSUVH MA Inhibitor DMKSUVH RN Synthesis and serotonin transporter activity of sulphur-substituted alpha-alkyl phenethylamines as a new class of anticancer agents. Eur J Med Chem. 2009 Dec;44(12):4862-88. DMKSUVH RU https://pubmed.ncbi.nlm.nih.gov/19717215 DM5S0BY DI DM5S0BY DM5S0BY DN 2-N-Allylamino-1-(4-methylthiophenyl)propan DM5S0BY MI TT3ROYC DM5S0BY MN Serotonin transporter (SERT) DM5S0BY MT DTT DM5S0BY MA Inhibitor DM5S0BY RN Synthesis and serotonin transporter activity of sulphur-substituted alpha-alkyl phenethylamines as a new class of anticancer agents. Eur J Med Chem. 2009 Dec;44(12):4862-88. DM5S0BY RU https://pubmed.ncbi.nlm.nih.gov/19717215 DM2FTIC DI DM2FTIC DM2FTIC DN 2-NAP DM2FTIC MI TTCG0AL DM2FTIC MN Cholecystokinin receptor type A (CCKAR) DM2FTIC MT DTT DM2FTIC MA Antagonist DM2FTIC RN Unexpected relationship between plasma protein binding and the pharmacodynamics of 2-NAP, a CCK1-receptor antagonist. Br J Clin Pharmacol. 2007 May;63(5):618-22. DM2FTIC RU https://pubmed.ncbi.nlm.nih.gov/17052250 DMTSF6A DI DMTSF6A DMTSF6A DN 2-Naphthalen-1-yl-1H-[1,8]naphthyridin-4-one DMTSF6A MI TTML2WA DMTSF6A MN Tubulin (TUB) DMTSF6A MT DTT DMTSF6A MA Inhibitor DMTSF6A RN Antitumor agents. 178. Synthesis and biological evaluation of substituted 2-aryl-1,8-naphthyridin-4(1H)-ones as antitumor agents that inhibit tubul... J Med Chem. 1997 Sep 12;40(19):3049-56. DMTSF6A RU https://pubmed.ncbi.nlm.nih.gov/9301667 DMTSF6A DI DMTSF6A DMTSF6A DN 2-Naphthalen-1-yl-1H-[1,8]naphthyridin-4-one DMTSF6A MI TTYFKSZ DMTSF6A MN Tubulin beta (TUBB) DMTSF6A MT DTT DMTSF6A MA Inhibitor DMTSF6A RN Antitumor agents. 178. Synthesis and biological evaluation of substituted 2-aryl-1,8-naphthyridin-4(1H)-ones as antitumor agents that inhibit tubul... J Med Chem. 1997 Sep 12;40(19):3049-56. DMTSF6A RU https://pubmed.ncbi.nlm.nih.gov/9301667 DMBI6U9 DI DMBI6U9 DMBI6U9 DN 2-Naphthalen-1-yl-benzooxazol-6-ol DMBI6U9 MI TTZAYWL DMBI6U9 MN Estrogen receptor (ESR) DMBI6U9 MT DTT DMBI6U9 MA Inhibitor DMBI6U9 RN Design and synthesis of aryl diphenolic azoles as potent and selective estrogen receptor-beta ligands. J Med Chem. 2004 Oct 7;47(21):5021-40. DMBI6U9 RU https://pubmed.ncbi.nlm.nih.gov/15456246 DMBI6U9 DI DMBI6U9 DMBI6U9 DN 2-Naphthalen-1-yl-benzooxazol-6-ol DMBI6U9 MI TTOM3J0 DMBI6U9 MN Estrogen receptor beta (ESR2) DMBI6U9 MT DTT DMBI6U9 MA Inhibitor DMBI6U9 RN Design and synthesis of aryl diphenolic azoles as potent and selective estrogen receptor-beta ligands. J Med Chem. 2004 Oct 7;47(21):5021-40. DMBI6U9 RU https://pubmed.ncbi.nlm.nih.gov/15456246 DMIDGNB DI DMIDGNB DMIDGNB DN 2-Naphthalen-1-ylmethyl-1,2-dihydro-indazol-3-one DMIDGNB MI TT2J34L DMIDGNB MN Arachidonate 5-lipoxygenase (5-LOX) DMIDGNB MT DTT DMIDGNB MA Inhibitor DMIDGNB RN Indazolinones, a new series of redox-active 5-lipoxygenase inhibitors with built-in selectivity and oral activity. J Med Chem. 1991 Mar;34(3):1028-36. DMIDGNB RU https://pubmed.ncbi.nlm.nih.gov/1848292 DM12YH4 DI DM12YH4 DM12YH4 DN 2-Naphthalen-2-yl-1H-[1,8]naphthyridin-4-one DM12YH4 MI TTML2WA DM12YH4 MN Tubulin (TUB) DM12YH4 MT DTT DM12YH4 MA Inhibitor DM12YH4 RN Antitumor agents. 178. Synthesis and biological evaluation of substituted 2-aryl-1,8-naphthyridin-4(1H)-ones as antitumor agents that inhibit tubul... J Med Chem. 1997 Sep 12;40(19):3049-56. DM12YH4 RU https://pubmed.ncbi.nlm.nih.gov/9301667 DM12YH4 DI DM12YH4 DM12YH4 DN 2-Naphthalen-2-yl-1H-[1,8]naphthyridin-4-one DM12YH4 MI TTYFKSZ DM12YH4 MN Tubulin beta (TUBB) DM12YH4 MT DTT DM12YH4 MA Inhibitor DM12YH4 RN Antitumor agents. 178. Synthesis and biological evaluation of substituted 2-aryl-1,8-naphthyridin-4(1H)-ones as antitumor agents that inhibit tubul... J Med Chem. 1997 Sep 12;40(19):3049-56. DM12YH4 RU https://pubmed.ncbi.nlm.nih.gov/9301667 DM1EJ6W DI DM1EJ6W DM1EJ6W DN 2-Naphthalen-2-ylmethyl-1,2-dihydro-indazol-3-one DM1EJ6W MI TT2J34L DM1EJ6W MN Arachidonate 5-lipoxygenase (5-LOX) DM1EJ6W MT DTT DM1EJ6W MA Inhibitor DM1EJ6W RN Indazolinones, a new series of redox-active 5-lipoxygenase inhibitors with built-in selectivity and oral activity. J Med Chem. 1991 Mar;34(3):1028-36. DM1EJ6W RU https://pubmed.ncbi.nlm.nih.gov/1848292 DM1EJ6W DI DM1EJ6W DM1EJ6W DN 2-Naphthalen-2-ylmethyl-1,2-dihydro-indazol-3-one DM1EJ6W MI TT8NGED DM1EJ6W MN Prostaglandin G/H synthase 1 (COX-1) DM1EJ6W MT DTT DM1EJ6W MA Inhibitor DM1EJ6W RN Indazolinones, a new series of redox-active 5-lipoxygenase inhibitors with built-in selectivity and oral activity. J Med Chem. 1991 Mar;34(3):1028-36. DM1EJ6W RU https://pubmed.ncbi.nlm.nih.gov/1848292 DM1EJ6W DI DM1EJ6W DM1EJ6W DN 2-Naphthalen-2-ylmethyl-1,2-dihydro-indazol-3-one DM1EJ6W MI TTVKILB DM1EJ6W MN Prostaglandin G/H synthase 2 (COX-2) DM1EJ6W MT DTT DM1EJ6W MA Inhibitor DM1EJ6W RN Indazolinones, a new series of redox-active 5-lipoxygenase inhibitors with built-in selectivity and oral activity. J Med Chem. 1991 Mar;34(3):1028-36. DM1EJ6W RU https://pubmed.ncbi.nlm.nih.gov/1848292 DMNMEPB DI DMNMEPB DMNMEPB DN 2-Naphthalen-2-ylmethyl-4,5-dihydro-1H-imidazole DMNMEPB MI TT3ROYC DMNMEPB MN Serotonin transporter (SERT) DMNMEPB MT DTT DMNMEPB MA Inhibitor DMNMEPB RN Structure-activity studies for a novel series of N-(arylethyl)-N-(1,2,3,4-tetrahydronaphthalen-1-ylmethyl)-N-methylamine s possessing dual 5-HT upt... J Med Chem. 1997 Mar 28;40(7):1049-62. DMNMEPB RU https://pubmed.ncbi.nlm.nih.gov/9089327 DMZ4LJ7 DI DMZ4LJ7 DMZ4LJ7 DN 2-NAPHTHALENESULFONIC ACID DMZ4LJ7 MI TT6L509 DMZ4LJ7 MN Coagulation factor IIa (F2) DMZ4LJ7 MT DTT DMZ4LJ7 MA Inhibitor DMZ4LJ7 RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DMZ4LJ7 RU https://pubmed.ncbi.nlm.nih.gov/10592235 DMFXKN1 DI DMFXKN1 DMFXKN1 DN 2-nas-phe(3-am)-4-(2-guanidinoethyl)piperidine DMFXKN1 MI TT6L509 DMFXKN1 MN Coagulation factor IIa (F2) DMFXKN1 MT DTT DMFXKN1 MA Inhibitor DMFXKN1 RN Secondary amides of sulfonylated 3-amidinophenylalanine. New potent and selective inhibitors of matriptase. J Med Chem. 2006 Jul 13;49(14):4116-26. DMFXKN1 RU https://pubmed.ncbi.nlm.nih.gov/16821772 DMFXKN1 DI DMFXKN1 DMFXKN1 DN 2-nas-phe(3-am)-4-(2-guanidinoethyl)piperidine DMFXKN1 MI TTPRO7W DMFXKN1 MN Suppressor of tumorigenicity 14 protein (ST14) DMFXKN1 MT DTT DMFXKN1 MA Inhibitor DMFXKN1 RN Secondary amides of sulfonylated 3-amidinophenylalanine. New potent and selective inhibitors of matriptase. J Med Chem. 2006 Jul 13;49(14):4116-26. DMFXKN1 RU https://pubmed.ncbi.nlm.nih.gov/16821772 DMFXKN1 DI DMFXKN1 DMFXKN1 DN 2-nas-phe(3-am)-4-(2-guanidinoethyl)piperidine DMFXKN1 MI TTGY7WI DMFXKN1 MN Urokinase-type plasminogen activator (PLAU) DMFXKN1 MT DTT DMFXKN1 MA Inhibitor DMFXKN1 RN Secondary amides of sulfonylated 3-amidinophenylalanine. New potent and selective inhibitors of matriptase. J Med Chem. 2006 Jul 13;49(14):4116-26. DMFXKN1 RU https://pubmed.ncbi.nlm.nih.gov/16821772 DMS0NW3 DI DMS0NW3 DMS0NW3 DN 2-N-Cyclopropylamino-1-(4-methylthiophenyl)butane DMS0NW3 MI TT3ROYC DMS0NW3 MN Serotonin transporter (SERT) DMS0NW3 MT DTT DMS0NW3 MA Inhibitor DMS0NW3 RN Synthesis and serotonin transporter activity of sulphur-substituted alpha-alkyl phenethylamines as a new class of anticancer agents. Eur J Med Chem. 2009 Dec;44(12):4862-88. DMS0NW3 RU https://pubmed.ncbi.nlm.nih.gov/19717215 DMCYVS0 DI DMCYVS0 DMCYVS0 DN 2-N-Ethylamino-1-(4-ethylthiophenyl)butane DMCYVS0 MI TT3ROYC DMCYVS0 MN Serotonin transporter (SERT) DMCYVS0 MT DTT DMCYVS0 MA Inhibitor DMCYVS0 RN Synthesis and serotonin transporter activity of sulphur-substituted alpha-alkyl phenethylamines as a new class of anticancer agents. Eur J Med Chem. 2009 Dec;44(12):4862-88. DMCYVS0 RU https://pubmed.ncbi.nlm.nih.gov/19717215 DM64093 DI DM64093 DM64093 DN 2-N-Ethylamino-1-(4-ethylthiophenyl)propane DM64093 MI TT3ROYC DM64093 MN Serotonin transporter (SERT) DM64093 MT DTT DM64093 MA Inhibitor DM64093 RN Synthesis and serotonin transporter activity of sulphur-substituted alpha-alkyl phenethylamines as a new class of anticancer agents. Eur J Med Chem. 2009 Dec;44(12):4862-88. DM64093 RU https://pubmed.ncbi.nlm.nih.gov/19717215 DMKA3V2 DI DMKA3V2 DMKA3V2 DN 2-N-Ethylamino-1-(4-methylthiophenyl)butane DMKA3V2 MI TT3ROYC DMKA3V2 MN Serotonin transporter (SERT) DMKA3V2 MT DTT DMKA3V2 MA Inhibitor DMKA3V2 RN Synthesis and serotonin transporter activity of sulphur-substituted alpha-alkyl phenethylamines as a new class of anticancer agents. Eur J Med Chem. 2009 Dec;44(12):4862-88. DMKA3V2 RU https://pubmed.ncbi.nlm.nih.gov/19717215 DM6O1SY DI DM6O1SY DM6O1SY DN 2-N-Ethylamino-1-(4-methylthiophenyl)propane DM6O1SY MI TT3ROYC DM6O1SY MN Serotonin transporter (SERT) DM6O1SY MT DTT DM6O1SY MA Inhibitor DM6O1SY RN Synthesis and serotonin transporter activity of sulphur-substituted alpha-alkyl phenethylamines as a new class of anticancer agents. Eur J Med Chem. 2009 Dec;44(12):4862-88. DM6O1SY RU https://pubmed.ncbi.nlm.nih.gov/19717215 DM2MH6J DI DM2MH6J DM2MH6J DN 2-N-Hydroxyamino-1-(4-ethylthiophenyl)butane DM2MH6J MI TT3ROYC DM2MH6J MN Serotonin transporter (SERT) DM2MH6J MT DTT DM2MH6J MA Inhibitor DM2MH6J RN Synthesis and serotonin transporter activity of sulphur-substituted alpha-alkyl phenethylamines as a new class of anticancer agents. Eur J Med Chem. 2009 Dec;44(12):4862-88. DM2MH6J RU https://pubmed.ncbi.nlm.nih.gov/19717215 DMIQGWK DI DMIQGWK DMIQGWK DN 2-N-Hydroxyamino-1-(4-ethylthiophenyl)propane DMIQGWK MI TT3ROYC DMIQGWK MN Serotonin transporter (SERT) DMIQGWK MT DTT DMIQGWK MA Inhibitor DMIQGWK RN Synthesis and serotonin transporter activity of sulphur-substituted alpha-alkyl phenethylamines as a new class of anticancer agents. Eur J Med Chem. 2009 Dec;44(12):4862-88. DMIQGWK RU https://pubmed.ncbi.nlm.nih.gov/19717215 DME41NR DI DME41NR DME41NR DN 2-N-Hydroxyamino-1-(4-methylthiophenyl)butane DME41NR MI TT3ROYC DME41NR MN Serotonin transporter (SERT) DME41NR MT DTT DME41NR MA Inhibitor DME41NR RN Synthesis and serotonin transporter activity of sulphur-substituted alpha-alkyl phenethylamines as a new class of anticancer agents. Eur J Med Chem. 2009 Dec;44(12):4862-88. DME41NR RU https://pubmed.ncbi.nlm.nih.gov/19717215 DMZDYCW DI DMZDYCW DMZDYCW DN 2-N-Hydroxyamino-1-(4-methylthiophenyl)propane DMZDYCW MI TT3ROYC DMZDYCW MN Serotonin transporter (SERT) DMZDYCW MT DTT DMZDYCW MA Inhibitor DMZDYCW RN Synthesis and serotonin transporter activity of sulphur-substituted alpha-alkyl phenethylamines as a new class of anticancer agents. Eur J Med Chem. 2009 Dec;44(12):4862-88. DMZDYCW RU https://pubmed.ncbi.nlm.nih.gov/19717215 DM2NX4K DI DM2NX4K DM2NX4K DN 2'-Nitro-biphenyl-4-carboxylic acid hydroxyamide DM2NX4K MI TT2J34L DM2NX4K MN Arachidonate 5-lipoxygenase (5-LOX) DM2NX4K MT DTT DM2NX4K MA Inhibitor DM2NX4K RN Hydroxamic acid inhibitors of 5-lipoxygenase: quantitative structure-activity relationships. J Med Chem. 1990 Mar;33(3):992-8. DM2NX4K RU https://pubmed.ncbi.nlm.nih.gov/2308149 DMRZK9A DI DMRZK9A DMRZK9A DN 2-nitro-N-(2,4,5-trichlorophenyl)benzamide DMRZK9A MI TTVTX4N DMRZK9A MN Bacterial Fatty acid synthetase I (Bact inhA) DMRZK9A MT DTT DMRZK9A MA Inhibitor DMRZK9A RN Discovery of potential new InhA direct inhibitors based on pharmacophore and 3D-QSAR analysis followed by in silico screening. Eur J Med Chem. 2009 Sep;44(9):3718-30. DMRZK9A RU https://pubmed.ncbi.nlm.nih.gov/19428156 DM4Z56O DI DM4Z56O DM4Z56O DN 2-nitro-N-(quinolin-8-yl)benzenesulfonamide DM4Z56O MI TTSXVID DM4Z56O MN Nuclear factor NF-kappa-B (NFKB) DM4Z56O MT DTT DM4Z56O MA Inhibitor DM4Z56O RN Identification of N-(quinolin-8-yl)benzenesulfonamides as agents capable of down-regulating NFkappaB activity within two separate high-throughput s... Bioorg Med Chem Lett. 2008 Jan 1;18(1):329-35. DM4Z56O RU https://pubmed.ncbi.nlm.nih.gov/18024113 DMHCVKJ DI DMHCVKJ DMHCVKJ DN 2-N-Methoxyamino-1-(4-methylthiophenyl)propane DMHCVKJ MI TT3ROYC DMHCVKJ MN Serotonin transporter (SERT) DMHCVKJ MT DTT DMHCVKJ MA Inhibitor DMHCVKJ RN Synthesis and serotonin transporter activity of sulphur-substituted alpha-alkyl phenethylamines as a new class of anticancer agents. Eur J Med Chem. 2009 Dec;44(12):4862-88. DMHCVKJ RU https://pubmed.ncbi.nlm.nih.gov/19717215 DM1X5RY DI DM1X5RY DM1X5RY DN 2-N-Methylamino-1-(4-ethylthiophenyl)propane DM1X5RY MI TT3ROYC DM1X5RY MN Serotonin transporter (SERT) DM1X5RY MT DTT DM1X5RY MA Inhibitor DM1X5RY RN Synthesis and serotonin transporter activity of sulphur-substituted alpha-alkyl phenethylamines as a new class of anticancer agents. Eur J Med Chem. 2009 Dec;44(12):4862-88. DM1X5RY RU https://pubmed.ncbi.nlm.nih.gov/19717215 DMCR49K DI DMCR49K DMCR49K DN 2-N-Methylamino-1-(4-methylthiophenyl)butane DMCR49K MI TT3ROYC DMCR49K MN Serotonin transporter (SERT) DMCR49K MT DTT DMCR49K MA Inhibitor DMCR49K RN Synthesis and serotonin transporter activity of sulphur-substituted alpha-alkyl phenethylamines as a new class of anticancer agents. Eur J Med Chem. 2009 Dec;44(12):4862-88. DMCR49K RU https://pubmed.ncbi.nlm.nih.gov/19717215 DMVLX1T DI DMVLX1T DMVLX1T DN 2-N-Methylamino-1-(4-methylthiophenyl)propane DMVLX1T MI TT3ROYC DMVLX1T MN Serotonin transporter (SERT) DMVLX1T MT DTT DMVLX1T MA Inhibitor DMVLX1T RN Synthesis and serotonin transporter activity of sulphur-substituted alpha-alkyl phenethylamines as a new class of anticancer agents. Eur J Med Chem. 2009 Dec;44(12):4862-88. DMVLX1T RU https://pubmed.ncbi.nlm.nih.gov/19717215 DMQWR69 DI DMQWR69 DMQWR69 DN 2-NONYL-4-HYDROXYQUINOLINE N-OXIDE DMQWR69 MI TTRAMF0 DMQWR69 MN Plasmodium Cytochrome B (Malaria MT-CYB) DMQWR69 MT DTT DMQWR69 MA Inhibitor DMQWR69 RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DMQWR69 RU https://pubmed.ncbi.nlm.nih.gov/10592235 DMOGWIK DI DMOGWIK DMOGWIK DN 2-nonylamido-5-sulfonamidoindane DMOGWIK MI TTHQPL7 DMOGWIK MN Carbonic anhydrase I (CA-I) DMOGWIK MT DTT DMOGWIK MA Inhibitor DMOGWIK RN Indanesulfonamides as carbonic anhydrase inhibitors. Toward structure-based design of selective inhibitors of the tumor-associated isozyme CA IX. J Med Chem. 2006 May 4;49(9):2743-9. DMOGWIK RU https://pubmed.ncbi.nlm.nih.gov/16640335 DMOGWIK DI DMOGWIK DMOGWIK DN 2-nonylamido-5-sulfonamidoindane DMOGWIK MI TTANPDJ DMOGWIK MN Carbonic anhydrase II (CA-II) DMOGWIK MT DTT DMOGWIK MA Inhibitor DMOGWIK RN Indanesulfonamides as carbonic anhydrase inhibitors. Toward structure-based design of selective inhibitors of the tumor-associated isozyme CA IX. J Med Chem. 2006 May 4;49(9):2743-9. DMOGWIK RU https://pubmed.ncbi.nlm.nih.gov/16640335 DMOGWIK DI DMOGWIK DMOGWIK DN 2-nonylamido-5-sulfonamidoindane DMOGWIK MI TT2LVK8 DMOGWIK MN Carbonic anhydrase IX (CA-IX) DMOGWIK MT DTT DMOGWIK MA Inhibitor DMOGWIK RN Indanesulfonamides as carbonic anhydrase inhibitors. Toward structure-based design of selective inhibitors of the tumor-associated isozyme CA IX. J Med Chem. 2006 May 4;49(9):2743-9. DMOGWIK RU https://pubmed.ncbi.nlm.nih.gov/16640335 DMRXDS2 DI DMRXDS2 DMRXDS2 DN 2np8 DMRXDS2 MI TTLYXIT DMRXDS2 MN Aurora kinase C (AURKC) DMRXDS2 MT DTT DMRXDS2 MA Inhibitor DMRXDS2 RN Structural basis for the inhibition of Aurora A kinase by a novel class of high affinity disubstituted pyrimidine inhibitors. Bioorg Med Chem Lett. 2007 Feb 1;17(3):688-91. DMRXDS2 RU https://pubmed.ncbi.nlm.nih.gov/17157005 DMLZCOU DI DMLZCOU DMLZCOU DN 2-N-Propargylamino-1-(4-methylthiophenyl)butane DMLZCOU MI TT3ROYC DMLZCOU MN Serotonin transporter (SERT) DMLZCOU MT DTT DMLZCOU MA Inhibitor DMLZCOU RN Synthesis and serotonin transporter activity of sulphur-substituted alpha-alkyl phenethylamines as a new class of anticancer agents. Eur J Med Chem. 2009 Dec;44(12):4862-88. DMLZCOU RU https://pubmed.ncbi.nlm.nih.gov/19717215 DM9HPG1 DI DM9HPG1 DM9HPG1 DN 2-N-Propargylamino-1-(4-methylthiophenyl)propane DM9HPG1 MI TT3ROYC DM9HPG1 MN Serotonin transporter (SERT) DM9HPG1 MT DTT DM9HPG1 MA Inhibitor DM9HPG1 RN Synthesis and serotonin transporter activity of sulphur-substituted alpha-alkyl phenethylamines as a new class of anticancer agents. Eur J Med Chem. 2009 Dec;44(12):4862-88. DM9HPG1 RU https://pubmed.ncbi.nlm.nih.gov/19717215 DMZK0JV DI DMZK0JV DMZK0JV DN 2-O-ethyl-PAF C-16 DMZK0JV MI TTQL5VC DMZK0JV MN Platelet-activating factor receptor (PTAFR) DMZK0JV MT DTT DMZK0JV MA Agonist DMZK0JV RN A radioreceptor binding assay for platelet-activating factor (PAF) using membranes from CHO cells expressing human PAF receptor. J Immunol Methods. 1995 Oct 26;186(2):225-31. DMZK0JV RU https://pubmed.ncbi.nlm.nih.gov/7594622 DM5PXQU DI DM5PXQU DM5PXQU DN 2-oleoyl glycerol DM5PXQU MI TT7QNVC DM5PXQU MN Glucose-dependent insulinotropic receptor (GPR119) DM5PXQU MT DTT DM5PXQU MA Agonist DM5PXQU RN 2-Oleoyl glycerol is a GPR119 agonist and signals GLP-1 release in humans. J Clin Endocrinol Metab. 2011 Sep;96(9):E1409-17. DM5PXQU RU https://pubmed.ncbi.nlm.nih.gov/21778222 DMN9OS1 DI DMN9OS1 DMN9OS1 DN 2-oleoyl-LPA DMN9OS1 MI TT254XD DMN9OS1 MN Kynurenic acid receptor (GPR35) DMN9OS1 MT DTT DMN9OS1 MA Agonist DMN9OS1 RN GPR35 is a novel lysophosphatidic acid receptor. Biochem Biophys Res Commun. 2010 Apr 30;395(2):232-7. DMN9OS1 RU https://pubmed.ncbi.nlm.nih.gov/20361937 DMN9OS1 DI DMN9OS1 DMN9OS1 DN 2-oleoyl-LPA DMN9OS1 MI TTE2YJR DMN9OS1 MN Lysophosphatidate-3 receptor (LPAR3) DMN9OS1 MT DTT DMN9OS1 MA Agonist DMN9OS1 RN Lysophosphatidic acid (LPA) receptors of the EDG family are differentially activated by LPA species. Structure-activity relationship of cloned LPA receptors. FEBS Lett. 2000 Jul 28;478(1-2):159-65. DMN9OS1 RU https://pubmed.ncbi.nlm.nih.gov/10922489 DMN9OS1 DI DMN9OS1 DMN9OS1 DN 2-oleoyl-LPA DMN9OS1 MI TTQ6S1K DMN9OS1 MN Lysophosphatidic acid receptor 1 (LPAR1) DMN9OS1 MT DTT DMN9OS1 MA Agonist DMN9OS1 RN Lysophosphatidic acid (LPA) receptors of the EDG family are differentially activated by LPA species. Structure-activity relationship of cloned LPA receptors. FEBS Lett. 2000 Jul 28;478(1-2):159-65. DMN9OS1 RU https://pubmed.ncbi.nlm.nih.gov/10922489 DMN9OS1 DI DMN9OS1 DMN9OS1 DN 2-oleoyl-LPA DMN9OS1 MI TTB7Y8I DMN9OS1 MN Lysophosphatidic acid receptor 2 (LPAR2) DMN9OS1 MT DTT DMN9OS1 MA Agonist DMN9OS1 RN Lysophosphatidic acid (LPA) receptors of the EDG family are differentially activated by LPA species. Structure-activity relationship of cloned LPA receptors. FEBS Lett. 2000 Jul 28;478(1-2):159-65. DMN9OS1 RU https://pubmed.ncbi.nlm.nih.gov/10922489 DMO6JRW DI DMO6JRW DMO6JRW DN 2'-O-Methyl G-Clamp Containing Oligonucleotides DMO6JRW MI TT8Z1FE DMO6JRW MN Human immunodeficiency virus Tat-TAR RNA interaction (HIV Tat-TAR PPI) DMO6JRW MT DTT DMO6JRW MA Inhibitor DMO6JRW RN The synthesis of 2'-O-methyl G-clamp containing oligonucleotides and their inhibition of the HIV-1 Tat-TAR interaction. Nucleosides Nucleotides Nucleic Acids. 2003 May-Aug;22(5-8):1259-62. DMO6JRW RU https://pubmed.ncbi.nlm.nih.gov/14565394 DME7K64 DI DME7K64 DME7K64 DN 2-O-methyl-PAF C-18 DME7K64 MI TTQL5VC DME7K64 MN Platelet-activating factor receptor (PTAFR) DME7K64 MT DTT DME7K64 MA Agonist DME7K64 RN A radioreceptor binding assay for platelet-activating factor (PAF) using membranes from CHO cells expressing human PAF receptor. J Immunol Methods. 1995 Oct 26;186(2):225-31. DME7K64 RU https://pubmed.ncbi.nlm.nih.gov/7594622 DM2NEX4 DI DM2NEX4 DM2NEX4 DN 2-Oxa-spiro[4.4]nonan-1-one DM2NEX4 MI TT1MPAY DM2NEX4 MN GABA(A) receptor alpha-1 (GABRA1) DM2NEX4 MT DTT DM2NEX4 MA Inhibitor DM2NEX4 RN Alpha-spirocyclopentyl- and alpha-spirocyclopropyl-gamma-butyrolactones: conformationally constrained derivatives of anticonvulsant and convulsant ... J Med Chem. 1994 Jan 21;37(2):275-86. DM2NEX4 RU https://pubmed.ncbi.nlm.nih.gov/8295215 DM2NEX4 DI DM2NEX4 DM2NEX4 DN 2-Oxa-spiro[4.4]nonan-1-one DM2NEX4 MI TTZA1NY DM2NEX4 MN GABA(A) receptor beta-2 (GABRB2) DM2NEX4 MT DTT DM2NEX4 MA Inhibitor DM2NEX4 RN Alpha-spirocyclopentyl- and alpha-spirocyclopropyl-gamma-butyrolactones: conformationally constrained derivatives of anticonvulsant and convulsant ... J Med Chem. 1994 Jan 21;37(2):275-86. DM2NEX4 RU https://pubmed.ncbi.nlm.nih.gov/8295215 DM2NEX4 DI DM2NEX4 DM2NEX4 DN 2-Oxa-spiro[4.4]nonan-1-one DM2NEX4 MI TT06RH5 DM2NEX4 MN GABA(A) receptor gamma-2 (GABRG2) DM2NEX4 MT DTT DM2NEX4 MA Inhibitor DM2NEX4 RN Alpha-spirocyclopentyl- and alpha-spirocyclopropyl-gamma-butyrolactones: conformationally constrained derivatives of anticonvulsant and convulsant ... J Med Chem. 1994 Jan 21;37(2):275-86. DM2NEX4 RU https://pubmed.ncbi.nlm.nih.gov/8295215 DM2NEX4 DI DM2NEX4 DM2NEX4 DN 2-Oxa-spiro[4.4]nonan-1-one DM2NEX4 MI TTNJYV2 DM2NEX4 MN Gamma-aminobutyric acid receptor (GAR) DM2NEX4 MT DTT DM2NEX4 MA Inhibitor DM2NEX4 RN Alpha-spirocyclopentyl- and alpha-spirocyclopropyl-gamma-butyrolactones: conformationally constrained derivatives of anticonvulsant and convulsant ... J Med Chem. 1994 Jan 21;37(2):275-86. DM2NEX4 RU https://pubmed.ncbi.nlm.nih.gov/8295215 DMFN769 DI DMFN769 DMFN769 DN 2-oxo-2H-chromene-3-carboxylic acid DMFN769 MI TTUNARX DMFN769 MN Carbonic anhydrase (CA) DMFN769 MT DTT DMFN769 MA Inhibitor DMFN769 RN Deciphering the mechanism of carbonic anhydrase inhibition with coumarins and thiocoumarins. J Med Chem. 2010 Jan 14;53(1):335-44. DMFN769 RU https://pubmed.ncbi.nlm.nih.gov/19911821 DMFN769 DI DMFN769 DMFN769 DN 2-oxo-2H-chromene-3-carboxylic acid DMFN769 MI TTHQPL7 DMFN769 MN Carbonic anhydrase I (CA-I) DMFN769 MT DTT DMFN769 MA Inhibitor DMFN769 RN Deciphering the mechanism of carbonic anhydrase inhibition with coumarins and thiocoumarins. J Med Chem. 2010 Jan 14;53(1):335-44. DMFN769 RU https://pubmed.ncbi.nlm.nih.gov/19911821 DMFN769 DI DMFN769 DMFN769 DN 2-oxo-2H-chromene-3-carboxylic acid DMFN769 MI TTZHA0O DMFN769 MN Carbonic anhydrase IV (CA-IV) DMFN769 MT DTT DMFN769 MA Inhibitor DMFN769 RN Deciphering the mechanism of carbonic anhydrase inhibition with coumarins and thiocoumarins. J Med Chem. 2010 Jan 14;53(1):335-44. DMFN769 RU https://pubmed.ncbi.nlm.nih.gov/19911821 DMFN769 DI DMFN769 DMFN769 DN 2-oxo-2H-chromene-3-carboxylic acid DMFN769 MI TT2LVK8 DMFN769 MN Carbonic anhydrase IX (CA-IX) DMFN769 MT DTT DMFN769 MA Inhibitor DMFN769 RN Deciphering the mechanism of carbonic anhydrase inhibition with coumarins and thiocoumarins. J Med Chem. 2010 Jan 14;53(1):335-44. DMFN769 RU https://pubmed.ncbi.nlm.nih.gov/19911821 DMFN769 DI DMFN769 DMFN769 DN 2-oxo-2H-chromene-3-carboxylic acid DMFN769 MI TTSYM0R DMFN769 MN Carbonic anhydrase XII (CA-XII) DMFN769 MT DTT DMFN769 MA Inhibitor DMFN769 RN Deciphering the mechanism of carbonic anhydrase inhibition with coumarins and thiocoumarins. J Med Chem. 2010 Jan 14;53(1):335-44. DMFN769 RU https://pubmed.ncbi.nlm.nih.gov/19911821 DMFN769 DI DMFN769 DMFN769 DN 2-oxo-2H-chromene-3-carboxylic acid DMFN769 MI TTEYTKG DMFN769 MN Carbonic anhydrase XIV (CA-XIV) DMFN769 MT DTT DMFN769 MA Inhibitor DMFN769 RN Deciphering the mechanism of carbonic anhydrase inhibition with coumarins and thiocoumarins. J Med Chem. 2010 Jan 14;53(1):335-44. DMFN769 RU https://pubmed.ncbi.nlm.nih.gov/19911821 DMZTCOM DI DMZTCOM DMZTCOM DN 2-oxo-2H-thiochromene-3-carboxylic acid DMZTCOM MI TTUNARX DMZTCOM MN Carbonic anhydrase (CA) DMZTCOM MT DTT DMZTCOM MA Inhibitor DMZTCOM RN Deciphering the mechanism of carbonic anhydrase inhibition with coumarins and thiocoumarins. J Med Chem. 2010 Jan 14;53(1):335-44. DMZTCOM RU https://pubmed.ncbi.nlm.nih.gov/19911821 DMZTCOM DI DMZTCOM DMZTCOM DN 2-oxo-2H-thiochromene-3-carboxylic acid DMZTCOM MI TTHQPL7 DMZTCOM MN Carbonic anhydrase I (CA-I) DMZTCOM MT DTT DMZTCOM MA Inhibitor DMZTCOM RN Deciphering the mechanism of carbonic anhydrase inhibition with coumarins and thiocoumarins. J Med Chem. 2010 Jan 14;53(1):335-44. DMZTCOM RU https://pubmed.ncbi.nlm.nih.gov/19911821 DMZTCOM DI DMZTCOM DMZTCOM DN 2-oxo-2H-thiochromene-3-carboxylic acid DMZTCOM MI TTANPDJ DMZTCOM MN Carbonic anhydrase II (CA-II) DMZTCOM MT DTT DMZTCOM MA Inhibitor DMZTCOM RN Deciphering the mechanism of carbonic anhydrase inhibition with coumarins and thiocoumarins. J Med Chem. 2010 Jan 14;53(1):335-44. DMZTCOM RU https://pubmed.ncbi.nlm.nih.gov/19911821 DMZTCOM DI DMZTCOM DMZTCOM DN 2-oxo-2H-thiochromene-3-carboxylic acid DMZTCOM MI TT2LVK8 DMZTCOM MN Carbonic anhydrase IX (CA-IX) DMZTCOM MT DTT DMZTCOM MA Inhibitor DMZTCOM RN Deciphering the mechanism of carbonic anhydrase inhibition with coumarins and thiocoumarins. J Med Chem. 2010 Jan 14;53(1):335-44. DMZTCOM RU https://pubmed.ncbi.nlm.nih.gov/19911821 DMZTCOM DI DMZTCOM DMZTCOM DN 2-oxo-2H-thiochromene-3-carboxylic acid DMZTCOM MI TTSYM0R DMZTCOM MN Carbonic anhydrase XII (CA-XII) DMZTCOM MT DTT DMZTCOM MA Inhibitor DMZTCOM RN Deciphering the mechanism of carbonic anhydrase inhibition with coumarins and thiocoumarins. J Med Chem. 2010 Jan 14;53(1):335-44. DMZTCOM RU https://pubmed.ncbi.nlm.nih.gov/19911821 DMZTCOM DI DMZTCOM DMZTCOM DN 2-oxo-2H-thiochromene-3-carboxylic acid DMZTCOM MI TTEYTKG DMZTCOM MN Carbonic anhydrase XIV (CA-XIV) DMZTCOM MT DTT DMZTCOM MA Inhibitor DMZTCOM RN Deciphering the mechanism of carbonic anhydrase inhibition with coumarins and thiocoumarins. J Med Chem. 2010 Jan 14;53(1):335-44. DMZTCOM RU https://pubmed.ncbi.nlm.nih.gov/19911821 DM3UY74 DI DM3UY74 DM3UY74 DN 2-oxoguaia-1,4(15), 11(13)-trien-12,8beta-olide DM3UY74 MI TTSXVID DM3UY74 MN Nuclear factor NF-kappa-B (NFKB) DM3UY74 MT DTT DM3UY74 MA Inhibitor DM3UY74 RN Development of a structural model for NF-kappaB inhibition of sesquiterpene lactones using self-organizing neural networks. J Med Chem. 2006 Apr 6;49(7):2241-52. DM3UY74 RU https://pubmed.ncbi.nlm.nih.gov/16570920 DM23WOV DI DM23WOV DM23WOV DN 2-oxoguaia-1,4,11(13)-trien-12,8alpha-olide DM23WOV MI TTSXVID DM23WOV MN Nuclear factor NF-kappa-B (NFKB) DM23WOV MT DTT DM23WOV MA Inhibitor DM23WOV RN Development of a structural model for NF-kappaB inhibition of sesquiterpene lactones using self-organizing neural networks. J Med Chem. 2006 Apr 6;49(7):2241-52. DM23WOV RU https://pubmed.ncbi.nlm.nih.gov/16570920 DMDKSZ0 DI DMDKSZ0 DMDKSZ0 DN 2-oxo-N-m-tolyl-2H-chromene-3-carboxamide DMDKSZ0 MI TT3WG5C DMDKSZ0 MN Monoamine oxidase type A (MAO-A) DMDKSZ0 MT DTT DMDKSZ0 MA Inhibitor DMDKSZ0 RN Synthesis, molecular modeling, and selective inhibitory activity against human monoamine oxidases of 3-carboxamido-7-substituted coumarins. J Med Chem. 2009 Apr 9;52(7):1935-42. DMDKSZ0 RU https://pubmed.ncbi.nlm.nih.gov/19267475 DMDKSZ0 DI DMDKSZ0 DMDKSZ0 DN 2-oxo-N-m-tolyl-2H-chromene-3-carboxamide DMDKSZ0 MI TTGP7BY DMDKSZ0 MN Monoamine oxidase type B (MAO-B) DMDKSZ0 MT DTT DMDKSZ0 MA Inhibitor DMDKSZ0 RN Synthesis, molecular modeling, and selective inhibitory activity against human monoamine oxidases of 3-carboxamido-7-substituted coumarins. J Med Chem. 2009 Apr 9;52(7):1935-42. DMDKSZ0 RU https://pubmed.ncbi.nlm.nih.gov/19267475 DMH8QWY DI DMH8QWY DMH8QWY DN 2-oxo-N-phenyl-2H-chromene-3-carboxamide DMH8QWY MI TT3WG5C DMH8QWY MN Monoamine oxidase type A (MAO-A) DMH8QWY MT DTT DMH8QWY MA Inhibitor DMH8QWY RN Synthesis, molecular modeling, and selective inhibitory activity against human monoamine oxidases of 3-carboxamido-7-substituted coumarins. J Med Chem. 2009 Apr 9;52(7):1935-42. DMH8QWY RU https://pubmed.ncbi.nlm.nih.gov/19267475 DMH8QWY DI DMH8QWY DMH8QWY DN 2-oxo-N-phenyl-2H-chromene-3-carboxamide DMH8QWY MI TTGP7BY DMH8QWY MN Monoamine oxidase type B (MAO-B) DMH8QWY MT DTT DMH8QWY MA Inhibitor DMH8QWY RN Synthesis, molecular modeling, and selective inhibitory activity against human monoamine oxidases of 3-carboxamido-7-substituted coumarins. J Med Chem. 2009 Apr 9;52(7):1935-42. DMH8QWY RU https://pubmed.ncbi.nlm.nih.gov/19267475 DMWXI6C DI DMWXI6C DMWXI6C DN 2-oxo-N-p-tolyl-2H-chromene-3-carboxamide DMWXI6C MI TT3WG5C DMWXI6C MN Monoamine oxidase type A (MAO-A) DMWXI6C MT DTT DMWXI6C MA Inhibitor DMWXI6C RN Synthesis, molecular modeling, and selective inhibitory activity against human monoamine oxidases of 3-carboxamido-7-substituted coumarins. J Med Chem. 2009 Apr 9;52(7):1935-42. DMWXI6C RU https://pubmed.ncbi.nlm.nih.gov/19267475 DMWXI6C DI DMWXI6C DMWXI6C DN 2-oxo-N-p-tolyl-2H-chromene-3-carboxamide DMWXI6C MI TTGP7BY DMWXI6C MN Monoamine oxidase type B (MAO-B) DMWXI6C MT DTT DMWXI6C MA Inhibitor DMWXI6C RN Synthesis, molecular modeling, and selective inhibitory activity against human monoamine oxidases of 3-carboxamido-7-substituted coumarins. J Med Chem. 2009 Apr 9;52(7):1935-42. DMWXI6C RU https://pubmed.ncbi.nlm.nih.gov/19267475 DMDMK81 DI DMDMK81 DMDMK81 DN 2-Oxoolean-12-en-28-oic acid DMDMK81 MI TTZHY6R DMDMK81 MN Glycogen phosphorylase muscle form (GP) DMDMK81 MT DTT DMDMK81 MA Inhibitor DMDMK81 RN Synthesis of 3-deoxypentacyclic triterpene derivatives as inhibitors of glycogen phosphorylase. J Nat Prod. 2009 Aug;72(8):1414-8. DMDMK81 RU https://pubmed.ncbi.nlm.nih.gov/19642687 DMZ9NCA DI DMZ9NCA DMZ9NCA DN 2-pentafluorophenylamido-5-sulfonamidoindane DMZ9NCA MI TTHQPL7 DMZ9NCA MN Carbonic anhydrase I (CA-I) DMZ9NCA MT DTT DMZ9NCA MA Inhibitor DMZ9NCA RN Indanesulfonamides as carbonic anhydrase inhibitors. Toward structure-based design of selective inhibitors of the tumor-associated isozyme CA IX. J Med Chem. 2006 May 4;49(9):2743-9. DMZ9NCA RU https://pubmed.ncbi.nlm.nih.gov/16640335 DMZ9NCA DI DMZ9NCA DMZ9NCA DN 2-pentafluorophenylamido-5-sulfonamidoindane DMZ9NCA MI TTANPDJ DMZ9NCA MN Carbonic anhydrase II (CA-II) DMZ9NCA MT DTT DMZ9NCA MA Inhibitor DMZ9NCA RN Indanesulfonamides as carbonic anhydrase inhibitors. Toward structure-based design of selective inhibitors of the tumor-associated isozyme CA IX. J Med Chem. 2006 May 4;49(9):2743-9. DMZ9NCA RU https://pubmed.ncbi.nlm.nih.gov/16640335 DMZ9NCA DI DMZ9NCA DMZ9NCA DN 2-pentafluorophenylamido-5-sulfonamidoindane DMZ9NCA MI TT2LVK8 DMZ9NCA MN Carbonic anhydrase IX (CA-IX) DMZ9NCA MT DTT DMZ9NCA MA Inhibitor DMZ9NCA RN Indanesulfonamides as carbonic anhydrase inhibitors. Toward structure-based design of selective inhibitors of the tumor-associated isozyme CA IX. J Med Chem. 2006 May 4;49(9):2743-9. DMZ9NCA RU https://pubmed.ncbi.nlm.nih.gov/16640335 DM032YM DI DM032YM DM032YM DN 2-pentenal DM032YM MI TTELV3W DM032YM MN Transformation-sensitive protein p120 (TRPA1) DM032YM MT DTT DM032YM MA Activator DM032YM RN Transient receptor potential ankyrin 1 (TRPA1) channel as emerging target for novel analgesics and anti-inflammatory agents. J Med Chem. 2010 Jul 22;53(14):5085-107. DM032YM RU https://pubmed.ncbi.nlm.nih.gov/20356305 DM0WMBC DI DM0WMBC DM0WMBC DN 2-Phenethyl-1,2-dihydro-indazol-3-one DM0WMBC MI TT2J34L DM0WMBC MN Arachidonate 5-lipoxygenase (5-LOX) DM0WMBC MT DTT DM0WMBC MA Inhibitor DM0WMBC RN Indazolinones, a new series of redox-active 5-lipoxygenase inhibitors with built-in selectivity and oral activity. J Med Chem. 1991 Mar;34(3):1028-36. DM0WMBC RU https://pubmed.ncbi.nlm.nih.gov/1848292 DM0WMBC DI DM0WMBC DM0WMBC DN 2-Phenethyl-1,2-dihydro-indazol-3-one DM0WMBC MI TT8NGED DM0WMBC MN Prostaglandin G/H synthase 1 (COX-1) DM0WMBC MT DTT DM0WMBC MA Inhibitor DM0WMBC RN Indazolinones, a new series of redox-active 5-lipoxygenase inhibitors with built-in selectivity and oral activity. J Med Chem. 1991 Mar;34(3):1028-36. DM0WMBC RU https://pubmed.ncbi.nlm.nih.gov/1848292 DM0WMBC DI DM0WMBC DM0WMBC DN 2-Phenethyl-1,2-dihydro-indazol-3-one DM0WMBC MI TTVKILB DM0WMBC MN Prostaglandin G/H synthase 2 (COX-2) DM0WMBC MT DTT DM0WMBC MA Inhibitor DM0WMBC RN Indazolinones, a new series of redox-active 5-lipoxygenase inhibitors with built-in selectivity and oral activity. J Med Chem. 1991 Mar;34(3):1028-36. DM0WMBC RU https://pubmed.ncbi.nlm.nih.gov/1848292 DM4H6PC DI DM4H6PC DM4H6PC DN 2-Phenethyl-4,5-dihydro-1H-imidazole DM4H6PC MI TT3WG5C DM4H6PC MN Monoamine oxidase type A (MAO-A) DM4H6PC MT DTT DM4H6PC MA Inhibitor DM4H6PC RN Binding of an imidazopyridoindole at imidazoline I2 receptors. Bioorg Med Chem Lett. 2004 Jan 19;14(2):527-9. DM4H6PC RU https://pubmed.ncbi.nlm.nih.gov/14698196 DM4H6PC DI DM4H6PC DM4H6PC DN 2-Phenethyl-4,5-dihydro-1H-imidazole DM4H6PC MI TTGP7BY DM4H6PC MN Monoamine oxidase type B (MAO-B) DM4H6PC MT DTT DM4H6PC MA Inhibitor DM4H6PC RN Binding of an imidazopyridoindole at imidazoline I2 receptors. Bioorg Med Chem Lett. 2004 Jan 19;14(2):527-9. DM4H6PC RU https://pubmed.ncbi.nlm.nih.gov/14698196 DMPWG21 DI DMPWG21 DMPWG21 DN 2-phenethylisoquinoline-1,3,4-trione DMPWG21 MI TTPF2QI DMPWG21 MN Caspase-3 (CASP3) DMPWG21 MT DTT DMPWG21 MA Inhibitor DMPWG21 RN Design, synthesis, and biological evaluation of isoquinoline-1,3,4-trione derivatives as potent caspase-3 inhibitors. J Med Chem. 2006 Mar 9;49(5):1613-23. DMPWG21 RU https://pubmed.ncbi.nlm.nih.gov/16509578 DMQX7FW DI DMQX7FW DMQX7FW DN 2-phenoxy-1-(2-p-tolylthiazolidin-3-yl)ethanone DMQX7FW MI TTW0CMT DMQX7FW MN Voltage-gated potassium channel Kv1.5 (KCNA5) DMQX7FW MT DTT DMQX7FW MA Inhibitor DMQX7FW RN Evolution of thiazolidine-based blockers of human Kv1.5 for the treatment of atrial arrhythmias. Bioorg Med Chem Lett. 2007 Jan 1;17(1):282-4. DMQX7FW RU https://pubmed.ncbi.nlm.nih.gov/17095219 DM6JNT5 DI DM6JNT5 DM6JNT5 DN 2-phenoxy-3-(piperidin-4-yl)pyridine DM6JNT5 MI TTSQIFT DM6JNT5 MN 5-HT 1A receptor (HTR1A) DM6JNT5 MT DTT DM6JNT5 MA Inhibitor DM6JNT5 RN Design, synthesis, and pharmacological evaluation of phenoxy pyridyl derivatives as dual norepinephrine reuptake inhibitors and 5-HT1A partial agon... Bioorg Med Chem Lett. 2010 Feb 1;20(3):1114-7. DM6JNT5 RU https://pubmed.ncbi.nlm.nih.gov/20031410 DM6JNT5 DI DM6JNT5 DM6JNT5 DN 2-phenoxy-3-(piperidin-4-yl)pyridine DM6JNT5 MI TTVBI8W DM6JNT5 MN Dopamine transporter (DAT) DM6JNT5 MT DTT DM6JNT5 MA Inhibitor DM6JNT5 RN Design, synthesis, and pharmacological evaluation of phenoxy pyridyl derivatives as dual norepinephrine reuptake inhibitors and 5-HT1A partial agon... Bioorg Med Chem Lett. 2010 Feb 1;20(3):1114-7. DM6JNT5 RU https://pubmed.ncbi.nlm.nih.gov/20031410 DM6JNT5 DI DM6JNT5 DM6JNT5 DN 2-phenoxy-3-(piperidin-4-yl)pyridine DM6JNT5 MI TTAWNKZ DM6JNT5 MN Norepinephrine transporter (NET) DM6JNT5 MT DTT DM6JNT5 MA Inhibitor DM6JNT5 RN Design, synthesis, and pharmacological evaluation of phenoxy pyridyl derivatives as dual norepinephrine reuptake inhibitors and 5-HT1A partial agon... Bioorg Med Chem Lett. 2010 Feb 1;20(3):1114-7. DM6JNT5 RU https://pubmed.ncbi.nlm.nih.gov/20031410 DM6JNT5 DI DM6JNT5 DM6JNT5 DN 2-phenoxy-3-(piperidin-4-yl)pyridine DM6JNT5 MI TT3ROYC DM6JNT5 MN Serotonin transporter (SERT) DM6JNT5 MT DTT DM6JNT5 MA Inhibitor DM6JNT5 RN Design, synthesis, and pharmacological evaluation of phenoxy pyridyl derivatives as dual norepinephrine reuptake inhibitors and 5-HT1A partial agon... Bioorg Med Chem Lett. 2010 Feb 1;20(3):1114-7. DM6JNT5 RU https://pubmed.ncbi.nlm.nih.gov/20031410 DM5E74G DI DM5E74G DM5E74G DN 2-Phenoxymethyl-4,5-dihydro-1H-imidazole DM5E74G MI TT3WG5C DM5E74G MN Monoamine oxidase type A (MAO-A) DM5E74G MT DTT DM5E74G MA Inhibitor DM5E74G RN Binding of an imidazopyridoindole at imidazoline I2 receptors. Bioorg Med Chem Lett. 2004 Jan 19;14(2):527-9. DM5E74G RU https://pubmed.ncbi.nlm.nih.gov/14698196 DM5E74G DI DM5E74G DM5E74G DN 2-Phenoxymethyl-4,5-dihydro-1H-imidazole DM5E74G MI TTGP7BY DM5E74G MN Monoamine oxidase type B (MAO-B) DM5E74G MT DTT DM5E74G MA Inhibitor DM5E74G RN Binding of an imidazopyridoindole at imidazoline I2 receptors. Bioorg Med Chem Lett. 2004 Jan 19;14(2):527-9. DM5E74G RU https://pubmed.ncbi.nlm.nih.gov/14698196 DMERNSK DI DMERNSK DMERNSK DN 2-phenyl-1,1-di(pyridin-3-yl)ethanol DMERNSK MI TTW0CMT DMERNSK MN Voltage-gated potassium channel Kv1.5 (KCNA5) DMERNSK MT DTT DMERNSK MA Inhibitor DMERNSK RN Discovery of triarylethanolamine inhibitors of the Kv1.5 potassium channel. Bioorg Med Chem Lett. 2010 Apr 15;20(8):2493-6. DMERNSK RU https://pubmed.ncbi.nlm.nih.gov/20304642 DM28CLZ DI DM28CLZ DM28CLZ DN 2-Phenyl-1,2-dihydro-indazol-3-one DM28CLZ MI TT2J34L DM28CLZ MN Arachidonate 5-lipoxygenase (5-LOX) DM28CLZ MT DTT DM28CLZ MA Inhibitor DM28CLZ RN Indazolinones, a new series of redox-active 5-lipoxygenase inhibitors with built-in selectivity and oral activity. J Med Chem. 1991 Mar;34(3):1028-36. DM28CLZ RU https://pubmed.ncbi.nlm.nih.gov/1848292 DM28CLZ DI DM28CLZ DM28CLZ DN 2-Phenyl-1,2-dihydro-indazol-3-one DM28CLZ MI TT8NGED DM28CLZ MN Prostaglandin G/H synthase 1 (COX-1) DM28CLZ MT DTT DM28CLZ MA Inhibitor DM28CLZ RN Indazolinones, a new series of redox-active 5-lipoxygenase inhibitors with built-in selectivity and oral activity. J Med Chem. 1991 Mar;34(3):1028-36. DM28CLZ RU https://pubmed.ncbi.nlm.nih.gov/1848292 DM28CLZ DI DM28CLZ DM28CLZ DN 2-Phenyl-1,2-dihydro-indazol-3-one DM28CLZ MI TTVKILB DM28CLZ MN Prostaglandin G/H synthase 2 (COX-2) DM28CLZ MT DTT DM28CLZ MA Inhibitor DM28CLZ RN Indazolinones, a new series of redox-active 5-lipoxygenase inhibitors with built-in selectivity and oral activity. J Med Chem. 1991 Mar;34(3):1028-36. DM28CLZ RU https://pubmed.ncbi.nlm.nih.gov/1848292 DMP8G3C DI DMP8G3C DMP8G3C DN 2-phenyl-1,2'-spirobi[1H-indene]-5'-ol DMP8G3C MI TTZAYWL DMP8G3C MN Estrogen receptor (ESR) DMP8G3C MT DTT DMP8G3C MA Inhibitor DMP8G3C RN 2-Phenylspiroindenes: a novel class of selective estrogen receptor modulators (SERMs). Bioorg Med Chem Lett. 2003 Feb 10;13(3):479-83. DMP8G3C RU https://pubmed.ncbi.nlm.nih.gov/12565955 DMP8G3C DI DMP8G3C DMP8G3C DN 2-phenyl-1,2'-spirobi[1H-indene]-5'-ol DMP8G3C MI TTOM3J0 DMP8G3C MN Estrogen receptor beta (ESR2) DMP8G3C MT DTT DMP8G3C MA Inhibitor DMP8G3C RN 2-Phenylspiroindenes: a novel class of selective estrogen receptor modulators (SERMs). Bioorg Med Chem Lett. 2003 Feb 10;13(3):479-83. DMP8G3C RU https://pubmed.ncbi.nlm.nih.gov/12565955 DM3WOHI DI DM3WOHI DM3WOHI DN 2-phenyl-1,8-naphthyridine DM3WOHI MI TTHS256 DM3WOHI MN Metabotropic glutamate receptor 5 (mGluR5) DM3WOHI MT DTT DM3WOHI MA Inhibitor DM3WOHI RN Synthesis and SAR comparison of regioisomeric aryl naphthyridines as potent mGlu5 receptor antagonists. Bioorg Med Chem Lett. 2007 Dec 1;17(23):6525-8. DM3WOHI RU https://pubmed.ncbi.nlm.nih.gov/17936624 DMDC6XP DI DMDC6XP DMDC6XP DN 2-Phenyl-1H-imidazo[4,5-c]quinolin-4-ylamine DMDC6XP MI TTK25J1 DMDC6XP MN Adenosine A1 receptor (ADORA1) DMDC6XP MT DTT DMDC6XP MA Inhibitor DMDC6XP RN 1H-imidazo[4,5-c]quinolin-4-amines: novel non-xanthine adenosine antagonists. J Med Chem. 1991 Mar;34(3):1202-6. DMDC6XP RU https://pubmed.ncbi.nlm.nih.gov/2002461 DMDC6XP DI DMDC6XP DMDC6XP DN 2-Phenyl-1H-imidazo[4,5-c]quinolin-4-ylamine DMDC6XP MI TTM2AOE DMDC6XP MN Adenosine A2a receptor (ADORA2A) DMDC6XP MT DTT DMDC6XP MA Inhibitor DMDC6XP RN 1H-imidazo[4,5-c]quinolin-4-amines: novel non-xanthine adenosine antagonists. J Med Chem. 1991 Mar;34(3):1202-6. DMDC6XP RU https://pubmed.ncbi.nlm.nih.gov/2002461 DMDC6XP DI DMDC6XP DMDC6XP DN 2-Phenyl-1H-imidazo[4,5-c]quinolin-4-ylamine DMDC6XP MI TTNE7KG DMDC6XP MN Adenosine A2b receptor (ADORA2B) DMDC6XP MT DTT DMDC6XP MA Inhibitor DMDC6XP RN 1H-imidazo[4,5-c]quinolin-4-amines: novel non-xanthine adenosine antagonists. J Med Chem. 1991 Mar;34(3):1202-6. DMDC6XP RU https://pubmed.ncbi.nlm.nih.gov/2002461 DMZI7O1 DI DMZI7O1 DMZI7O1 DN 2-phenyl-1H-imidazole-4-carboxylic acid DMZI7O1 MI TTHI19T DMZI7O1 MN Staphylococcus Beta-lactamase (Stap-coc blaZ) DMZI7O1 MT DTT DMZI7O1 MA Inhibitor DMZI7O1 RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DMZI7O1 RU https://pubmed.ncbi.nlm.nih.gov/10592235 DMRNZ4X DI DMRNZ4X DMRNZ4X DN 2-phenyl-2,3-dihydrobenzo[h]chromen-4-one DMRNZ4X MI TTSZLWK DMRNZ4X MN Aromatase (CYP19A1) DMRNZ4X MT DTT DMRNZ4X MA Inhibitor DMRNZ4X RN New 7,8-benzoflavanones as potent aromatase inhibitors: synthesis and biological evaluation. Bioorg Med Chem. 2008 Feb 1;16(3):1474-80. DMRNZ4X RU https://pubmed.ncbi.nlm.nih.gov/18042388 DMTSBJL DI DMTSBJL DMTSBJL DN 2-phenyl-2H-benzo[d][1,2,3]triazole-4-carboxamide DMTSBJL MI TTVDSZ0 DMTSBJL MN Poly [ADP-ribose] polymerase 1 (PARP1) DMTSBJL MT DTT DMTSBJL MA Inhibitor DMTSBJL RN Discovery of 2-{4-[(3S)-piperidin-3-yl]phenyl}-2H-indazole-7-carboxamide (MK-4827): a novel oral poly(ADP-ribose)polymerase (PARP) inhibitor effica... J Med Chem. 2009 Nov 26;52(22):7170-85. DMTSBJL RU https://pubmed.ncbi.nlm.nih.gov/19873981 DM8HSMU DI DM8HSMU DM8HSMU DN 2-phenyl-2H-indazole-7-carboxamide DM8HSMU MI TTVDSZ0 DM8HSMU MN Poly [ADP-ribose] polymerase 1 (PARP1) DM8HSMU MT DTT DM8HSMU MA Inhibitor DM8HSMU RN Discovery of 2-{4-[(3S)-piperidin-3-yl]phenyl}-2H-indazole-7-carboxamide (MK-4827): a novel oral poly(ADP-ribose)polymerase (PARP) inhibitor effica... J Med Chem. 2009 Nov 26;52(22):7170-85. DM8HSMU RU https://pubmed.ncbi.nlm.nih.gov/19873981 DMFE2R1 DI DMFE2R1 DMFE2R1 DN 2-phenyl-2H-pyrazolo[3,4-c]quinolin-4(5H)-one DMFE2R1 MI TTK25J1 DMFE2R1 MN Adenosine A1 receptor (ADORA1) DMFE2R1 MT DTT DMFE2R1 MA Inhibitor DMFE2R1 RN New 2-arylpyrazolo[3,4-c]quinoline derivatives as potent and selective human A3 adenosine receptor antagonists. Synthesis, pharmacological evaluati... J Med Chem. 2007 Aug 23;50(17):4061-74. DMFE2R1 RU https://pubmed.ncbi.nlm.nih.gov/17665891 DM5WOSM DI DM5WOSM DM5WOSM DN 2-phenyl-2H-pyrazolo[3,4-c]quinolin-4-amine DM5WOSM MI TTK25J1 DM5WOSM MN Adenosine A1 receptor (ADORA1) DM5WOSM MT DTT DM5WOSM MA Inhibitor DM5WOSM RN New 2-arylpyrazolo[3,4-c]quinoline derivatives as potent and selective human A3 adenosine receptor antagonists. Synthesis, pharmacological evaluati... J Med Chem. 2007 Aug 23;50(17):4061-74. DM5WOSM RU https://pubmed.ncbi.nlm.nih.gov/17665891 DM5WOSM DI DM5WOSM DM5WOSM DN 2-phenyl-2H-pyrazolo[3,4-c]quinolin-4-amine DM5WOSM MI TTM2AOE DM5WOSM MN Adenosine A2a receptor (ADORA2A) DM5WOSM MT DTT DM5WOSM MA Inhibitor DM5WOSM RN New 2-arylpyrazolo[3,4-c]quinoline derivatives as potent and selective human A3 adenosine receptor antagonists. Synthesis, pharmacological evaluati... J Med Chem. 2007 Aug 23;50(17):4061-74. DM5WOSM RU https://pubmed.ncbi.nlm.nih.gov/17665891 DMAHI7G DI DMAHI7G DMAHI7G DN 2-Phenyl-2H-pyrazolo[4,3-c]quinoline DMAHI7G MI TTJFY5U DMAHI7G MN Adenosine A3 receptor (ADORA3) DMAHI7G MT DTT DMAHI7G MA Inhibitor DMAHI7G RN New 2-arylpyrazolo[4,3-c]quinoline derivatives as potent and selective human A3 adenosine receptor antagonists. J Med Chem. 2005 Jul 28;48(15):5001-8. DMAHI7G RU https://pubmed.ncbi.nlm.nih.gov/16033279 DMQXCIK DI DMQXCIK DMQXCIK DN 2-phenyl-2H-pyrazolo[4,3-d]pyrimidin-7(6H)-one DMQXCIK MI TTJFY5U DMQXCIK MN Adenosine A3 receptor (ADORA3) DMQXCIK MT DTT DMQXCIK MA Inhibitor DMQXCIK RN 2-Phenylpyrazolo[4,3-d]pyrimidin-7-one as a new scaffold to obtain potent and selective human A3 adenosine receptor antagonists: new insights into ... J Med Chem. 2009 Dec 10;52(23):7640-52. DMQXCIK RU https://pubmed.ncbi.nlm.nih.gov/19743865 DMNXI6D DI DMNXI6D DMNXI6D DN 2-Phenyl-3-(1-phenyl-ethoxy)-piperidine DMNXI6D MI TTZPO1L DMNXI6D MN Substance-P receptor (TACR1) DMNXI6D MT DTT DMNXI6D MA Inhibitor DMNXI6D RN 3-Benzyloxy-2-phenylpiperidine NK1 antagonists: the influence of alpha methyl substitution, Bioorg. Med. Chem. Lett. 7(23):2959-2962 (1997). DMNXI6D RU http://www.sciencedirect.com/science/article/pii/S0960894X97101184 DM5YC2K DI DM5YC2K DM5YC2K DN 2-Phenyl-3-(2-piperidin-1-yl-ethyl)-1H-indole DM5YC2K MI TTJQOD7 DM5YC2K MN 5-HT 2A receptor (HTR2A) DM5YC2K MT DTT DM5YC2K MA Inhibitor DM5YC2K RN 3-(4-Piperidinyl)- and 3-(8-aza-bicyclo[3.2.1]oct-3-yl)-2-phenyl-1H-indoles as bioavailable h5-HT2A antagonists. Bioorg Med Chem Lett. 2000 Dec 18;10(24):2701-3. DM5YC2K RU https://pubmed.ncbi.nlm.nih.gov/11133072 DML9DJP DI DML9DJP DML9DJP DN 2-Phenyl-3H-imidazo[4,5-c]quinoline DML9DJP MI TT1MPAY DML9DJP MN GABA(A) receptor alpha-1 (GABRA1) DML9DJP MT DTT DML9DJP MA Inhibitor DML9DJP RN Synthesis and structure--activity relationships of fused imidazopyridines: a new series of benzodiazepine receptor ligands. J Med Chem. 1996 Jul 5;39(14):2844-51. DML9DJP RU https://pubmed.ncbi.nlm.nih.gov/8709114 DML9DJP DI DML9DJP DML9DJP DN 2-Phenyl-3H-imidazo[4,5-c]quinoline DML9DJP MI TTNJYV2 DML9DJP MN Gamma-aminobutyric acid receptor (GAR) DML9DJP MT DTT DML9DJP MA Inhibitor DML9DJP RN Synthesis and structure--activity relationships of fused imidazopyridines: a new series of benzodiazepine receptor ligands. J Med Chem. 1996 Jul 5;39(14):2844-51. DML9DJP RU https://pubmed.ncbi.nlm.nih.gov/8709114 DMY6NIT DI DMY6NIT DMY6NIT DN 2-Phenyl-3-piperidin-3-yl-1H-indole DMY6NIT MI TTQ6VDM DMY6NIT MN Voltage-gated potassium channel Kv11.1 (KCNH2) DMY6NIT MT DTT DMY6NIT MA Inhibitor DMY6NIT RN 3-(4-Fluoropiperidin-3-yl)-2-phenylindoles as high affinity, selective, and orally bioavailable h5-HT(2A) receptor antagonists. J Med Chem. 2001 May 10;44(10):1603-14. DMY6NIT RU https://pubmed.ncbi.nlm.nih.gov/11334570 DMEXZQ5 DI DMEXZQ5 DMEXZQ5 DN 2-Phenyl-3-piperidin-4-yl-1H-indole DMEXZQ5 MI TTJQOD7 DMEXZQ5 MN 5-HT 2A receptor (HTR2A) DMEXZQ5 MT DTT DMEXZQ5 MA Inhibitor DMEXZQ5 RN 3-(4-Piperidinyl)- and 3-(8-aza-bicyclo[3.2.1]oct-3-yl)-2-phenyl-1H-indoles as bioavailable h5-HT2A antagonists. Bioorg Med Chem Lett. 2000 Dec 18;10(24):2701-3. DMEXZQ5 RU https://pubmed.ncbi.nlm.nih.gov/11133072 DMEXZQ5 DI DMEXZQ5 DMEXZQ5 DN 2-Phenyl-3-piperidin-4-yl-1H-indole DMEXZQ5 MI TTQ6VDM DMEXZQ5 MN Voltage-gated potassium channel Kv11.1 (KCNH2) DMEXZQ5 MT DTT DMEXZQ5 MA Inhibitor DMEXZQ5 RN 3-(4-Fluoropiperidin-3-yl)-2-phenylindoles as high affinity, selective, and orally bioavailable h5-HT(2A) receptor antagonists. J Med Chem. 2001 May 10;44(10):1603-14. DMEXZQ5 RU https://pubmed.ncbi.nlm.nih.gov/11334570 DMKCOS2 DI DMKCOS2 DMKCOS2 DN 2-Phenyl-3-pyridin-4-ylmethylene-chroman-4-one DMKCOS2 MI TTSZLWK DMKCOS2 MN Aromatase (CYP19A1) DMKCOS2 MT DTT DMKCOS2 MA Inhibitor DMKCOS2 RN New aromatase inhibitors. Synthesis and inhibitory activity of pyridinyl-substituted flavanone derivatives. Bioorg Med Chem Lett. 2002 Apr 8;12(7):1059-61. DMKCOS2 RU https://pubmed.ncbi.nlm.nih.gov/11909717 DMEXYSP DI DMEXYSP DMEXYSP DN 2-Phenyl-4-[1,2,4]triazol-1-yl-chroman-7-ol DMEXYSP MI TTSZLWK DMEXYSP MN Aromatase (CYP19A1) DMEXYSP MT DTT DMEXYSP MA Inhibitor DMEXYSP RN Synthesis and evaluation of 4-triazolylflavans as new aromatase inhibitors. Bioorg Med Chem Lett. 2004 Oct 18;14(20):5215-8. DMEXYSP RU https://pubmed.ncbi.nlm.nih.gov/15380230 DM7A3GO DI DM7A3GO DM7A3GO DN 2-Phenyl-5-(2-methylthiazol-4ylethynyl)pyridine DM7A3GO MI TTHS256 DM7A3GO MN Metabotropic glutamate receptor 5 (mGluR5) DM7A3GO MT DTT DM7A3GO MA Inhibitor DM7A3GO RN Structure-activity relationships comparing N-(6-methylpyridin-yl)-substituted aryl amides to 2-methyl-6-(substituted-arylethynyl)pyridines or 2-met... J Med Chem. 2009 Jun 11;52(11):3563-75. DM7A3GO RU https://pubmed.ncbi.nlm.nih.gov/19445453 DMUIYZB DI DMUIYZB DMUIYZB DN 2-Phenyl-5,6-dihydro-pyrazolo[1,5-c]quinazoline DMUIYZB MI TT1MPAY DMUIYZB MN GABA(A) receptor alpha-1 (GABRA1) DMUIYZB MT DTT DMUIYZB MA Inhibitor DMUIYZB RN Synthesis and binding activity of some pyrazolo[1,5-c]quinazolines as tools to verify an optional binding site of a benzodiazepine receptor ligand. J Med Chem. 1996 Jul 19;39(15):2915-21. DMUIYZB RU https://pubmed.ncbi.nlm.nih.gov/8709126 DMUIYZB DI DMUIYZB DMUIYZB DN 2-Phenyl-5,6-dihydro-pyrazolo[1,5-c]quinazoline DMUIYZB MI TTNJYV2 DMUIYZB MN Gamma-aminobutyric acid receptor (GAR) DMUIYZB MT DTT DMUIYZB MA Inhibitor DMUIYZB RN Synthesis and binding activity of some pyrazolo[1,5-c]quinazolines as tools to verify an optional binding site of a benzodiazepine receptor ligand. J Med Chem. 1996 Jul 19;39(15):2915-21. DMUIYZB RU https://pubmed.ncbi.nlm.nih.gov/8709126 DMMDS2T DI DMMDS2T DMMDS2T DN 2-phenyl-5H-indeno[1,2-d]pyrimidine DMMDS2T MI TT3WG5C DMMDS2T MN Monoamine oxidase type A (MAO-A) DMMDS2T MT DTT DMMDS2T MA Inhibitor DMMDS2T RN Synthesis and monoamine oxidase inhibitory activity of new pyridazine-, pyrimidine- and 1,2,4-triazine-containing tricyclic derivatives. J Med Chem. 2007 Nov 1;50(22):5364-71. DMMDS2T RU https://pubmed.ncbi.nlm.nih.gov/17910428 DMA1RHE DI DMA1RHE DMA1RHE DN 2-Phenyl-6H-pyrazolo[1,5-c]quinazolin-5-one DMA1RHE MI TT1MPAY DMA1RHE MN GABA(A) receptor alpha-1 (GABRA1) DMA1RHE MT DTT DMA1RHE MA Inhibitor DMA1RHE RN Synthesis and binding activity of some pyrazolo[1,5-c]quinazolines as tools to verify an optional binding site of a benzodiazepine receptor ligand. J Med Chem. 1996 Jul 19;39(15):2915-21. DMA1RHE RU https://pubmed.ncbi.nlm.nih.gov/8709126 DMA1RHE DI DMA1RHE DMA1RHE DN 2-Phenyl-6H-pyrazolo[1,5-c]quinazolin-5-one DMA1RHE MI TTNJYV2 DMA1RHE MN Gamma-aminobutyric acid receptor (GAR) DMA1RHE MT DTT DMA1RHE MA Inhibitor DMA1RHE RN Synthesis and binding activity of some pyrazolo[1,5-c]quinazolines as tools to verify an optional binding site of a benzodiazepine receptor ligand. J Med Chem. 1996 Jul 19;39(15):2915-21. DMA1RHE RU https://pubmed.ncbi.nlm.nih.gov/8709126 DMY9ERA DI DMY9ERA DMY9ERA DN 2-Phenyl-6-propyl-chromen-4-one DMY9ERA MI TTNJYV2 DMY9ERA MN Gamma-aminobutyric acid receptor (GAR) DMY9ERA MT DTT DMY9ERA MA Inhibitor DMY9ERA RN Refinement and evaluation of a pharmacophore model for flavone derivatives binding to the benzodiazepine site of the GABA(A) receptor. J Med Chem. 2002 Sep 12;45(19):4188-201. DMY9ERA RU https://pubmed.ncbi.nlm.nih.gov/12213060 DMMHSYV DI DMMHSYV DMMHSYV DN 2-phenyl-9H-indeno[2,1-d]pyrimidine DMMHSYV MI TT3WG5C DMMHSYV MN Monoamine oxidase type A (MAO-A) DMMHSYV MT DTT DMMHSYV MA Inhibitor DMMHSYV RN Synthesis and monoamine oxidase inhibitory activity of new pyridazine-, pyrimidine- and 1,2,4-triazine-containing tricyclic derivatives. J Med Chem. 2007 Nov 1;50(22):5364-71. DMMHSYV RU https://pubmed.ncbi.nlm.nih.gov/17910428 DMMHSYV DI DMMHSYV DMMHSYV DN 2-phenyl-9H-indeno[2,1-d]pyrimidine DMMHSYV MI TTGP7BY DMMHSYV MN Monoamine oxidase type B (MAO-B) DMMHSYV MT DTT DMMHSYV MA Inhibitor DMMHSYV RN Synthesis and monoamine oxidase inhibitory activity of new pyridazine-, pyrimidine- and 1,2,4-triazine-containing tricyclic derivatives. J Med Chem. 2007 Nov 1;50(22):5364-71. DMMHSYV RU https://pubmed.ncbi.nlm.nih.gov/17910428 DM60AJ2 DI DM60AJ2 DM60AJ2 DN 2-PHENYLAMINO-4-METHYL-5-ACETYL THIAZOLE DM60AJ2 MI TTPH97Y DM60AJ2 MN Mycobacterium 3-oxoacyl-[acyl-carrier-protein] synthase 1 (MycB kasA) DM60AJ2 MT DTT DM60AJ2 MA Inhibitor DM60AJ2 RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DM60AJ2 RU https://pubmed.ncbi.nlm.nih.gov/10592235 DMW0M14 DI DMW0M14 DMW0M14 DN 2-phenylamino-9-(4-hydroxy-butyl)-6-oxopurine DMW0M14 MI TTP3QRF DMW0M14 MN Thymidine kinase 1 (TK1) DMW0M14 MT DTT DMW0M14 MA Inhibitor DMW0M14 RN Sensitivity of monkey B virus (Cercopithecine herpesvirus 1) to antiviral drugs: role of thymidine kinase in antiviral activities of substrate anal... Antimicrob Agents Chemother. 2007 Jun;51(6):2028-34. DMW0M14 RU https://pubmed.ncbi.nlm.nih.gov/17438061 DMUGH6J DI DMUGH6J DMUGH6J DN 2-Phenyl-cyclopropylamine hydrochloride DMUGH6J MI TTGP7BY DMUGH6J MN Monoamine oxidase type B (MAO-B) DMUGH6J MT DTT DMUGH6J MA Inhibitor DMUGH6J RN Fluorinated phenylcyclopropylamines. 2. Effects of aromatic ring substitution and of absolute configuration on inhibition of microbial tyramine oxi... J Med Chem. 2004 Nov 18;47(24):5860-71. DMUGH6J RU https://pubmed.ncbi.nlm.nih.gov/15537343 DMW3F5C DI DMW3F5C DMW3F5C DN 2-phenylethylyl-adenosine derivative DMW3F5C MI TTJFY5U DMW3F5C MN Adenosine A3 receptor (ADORA3) DMW3F5C MT DTT DMW3F5C MA Agonist DMW3F5C RN Synthesis and biological evaluation of 2-alkynyl-N6-methyl-5'-N-methylcarboxamidoadenosine derivatives as potent and highly selective agonists for the human adenosine A3 receptor. J Med Chem. 2009 Dec 10;52(23):7897-900. DMW3F5C RU https://pubmed.ncbi.nlm.nih.gov/19839592 DMNYOH5 DI DMNYOH5 DMNYOH5 DN 2-phenylethynyl-5,6,7,8-tetrahydro-quinolin-5-ol DMNYOH5 MI TTHS256 DMNYOH5 MN Metabotropic glutamate receptor 5 (mGluR5) DMNYOH5 MT DTT DMNYOH5 MA Inhibitor DMNYOH5 RN Positive and negative modulation of group I metabotropic glutamate receptors. J Med Chem. 2008 Feb 14;51(3):634-47. DMNYOH5 RU https://pubmed.ncbi.nlm.nih.gov/18173231 DM4LCRS DI DM4LCRS DM4LCRS DN 2-phenylethynyl-5,6,7,8-tetrahydro-quinoline DM4LCRS MI TTHS256 DM4LCRS MN Metabotropic glutamate receptor 5 (mGluR5) DM4LCRS MT DTT DM4LCRS MA Inhibitor DM4LCRS RN Positive and negative modulation of group I metabotropic glutamate receptors. J Med Chem. 2008 Feb 14;51(3):634-47. DM4LCRS RU https://pubmed.ncbi.nlm.nih.gov/18173231 DMFRQJ3 DI DMFRQJ3 DMFRQJ3 DN 2-phenylethynyl-7,8-dihydro-6H-quinolin-5-one DMFRQJ3 MI TTHS256 DMFRQJ3 MN Metabotropic glutamate receptor 5 (mGluR5) DMFRQJ3 MT DTT DMFRQJ3 MA Inhibitor DMFRQJ3 RN Positive and negative modulation of group I metabotropic glutamate receptors. J Med Chem. 2008 Feb 14;51(3):634-47. DMFRQJ3 RU https://pubmed.ncbi.nlm.nih.gov/18173231 DMPIQTE DI DMPIQTE DMPIQTE DN 2-Phenylheme DMPIQTE MI TTI6V2A DMPIQTE MN Heme oxygenase 1 (HMOX1) DMPIQTE MT DTT DMPIQTE MA Inhibitor DMPIQTE RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMPIQTE RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMFC3B5 DI DMFC3B5 DMFC3B5 DN 2-phenyl-N-(1,3,4-thiadiazol-2-yl)acetamide DMFC3B5 MI TTSJ6Q4 DMFC3B5 MN LOX-5 messenger RNA (ALOX5 mRNA) DMFC3B5 MT DTT DMFC3B5 MA Inhibitor DMFC3B5 RN Identification of natural-product-derived inhibitors of 5-lipoxygenase activity by ligand-based virtual screening. J Med Chem. 2007 May 31;50(11):2640-6. DMFC3B5 RU https://pubmed.ncbi.nlm.nih.gov/17461565 DMNOE0V DI DMNOE0V DMNOE0V DN 2-phenyl-N-(1-phenylethyl)quinoline-4-carboxamide DMNOE0V MI TTBPGLU DMNOE0V MN Neuromedin-K receptor (TACR3) DMNOE0V MT DTT DMNOE0V MA Inhibitor DMNOE0V RN Virtual screening to identify novel antagonists for the G protein-coupled NK3 receptor. J Med Chem. 2010 Nov 25;53(22):8080-8. DMNOE0V RU https://pubmed.ncbi.nlm.nih.gov/21047106 DMEFOV6 DI DMEFOV6 DMEFOV6 DN 2-phenyl-N-(pyridin-4-yl)quinazolin-4-amine DMEFOV6 MI TTP4520 DMEFOV6 MN TGF-beta receptor type I (TGFBR1) DMEFOV6 MT DTT DMEFOV6 MA Inhibitor DMEFOV6 RN Design of novel quinazoline derivatives and related analogues as potent and selective ALK5 inhibitors. Bioorg Med Chem Lett. 2009 Apr 15;19(8):2277-81. DMEFOV6 RU https://pubmed.ncbi.nlm.nih.gov/19285388 DMP0NW3 DI DMP0NW3 DMP0NW3 DN 2-phenyl-N-(thiazol-2-yl)acetamide DMP0NW3 MI TTSJ6Q4 DMP0NW3 MN LOX-5 messenger RNA (ALOX5 mRNA) DMP0NW3 MT DTT DMP0NW3 MA Inhibitor DMP0NW3 RN Identification of natural-product-derived inhibitors of 5-lipoxygenase activity by ligand-based virtual screening. J Med Chem. 2007 May 31;50(11):2640-6. DMP0NW3 RU https://pubmed.ncbi.nlm.nih.gov/17461565 DMMJENF DI DMMJENF DMMJENF DN 2-phenyl-N,N-bis(o-tolylthiomethyl)ethanamine DMMJENF MI TTX4RTB DMMJENF MN Melanin-concentrating hormone receptor 1 (MCHR1) DMMJENF MT DTT DMMJENF MA Inhibitor DMMJENF RN Discovery of novel chemotypes to a G-protein-coupled receptor through ligand-steered homology modeling and structure-based virtual screening. J Med Chem. 2008 Feb 14;51(3):581-8. DMMJENF RU https://pubmed.ncbi.nlm.nih.gov/18198821 DM7OHSX DI DM7OHSX DM7OHSX DN 2-phenylpiperidine hydrochloride DM7OHSX MI TTVBI8W DM7OHSX MN Dopamine transporter (DAT) DM7OHSX MT DTT DM7OHSX MA Inhibitor DM7OHSX RN Synthesis and pharmacology of site-specific cocaine abuse treatment agents: restricted rotation analogues of methylphenidate. J Med Chem. 2007 May 31;50(11):2718-31. DM7OHSX RU https://pubmed.ncbi.nlm.nih.gov/17489581 DMZQCEP DI DMZQCEP DMZQCEP DN 2-phenylpropoxyadenosine DMZQCEP MI TTK25J1 DMZQCEP MN Adenosine A1 receptor (ADORA1) DMZQCEP MT DTT DMZQCEP MA Inhibitor DMZQCEP RN Structure-activity relationships of 2,N(6),5'-substituted adenosine derivatives with potent activity at the A2B adenosine receptor. J Med Chem. 2007 Apr 19;50(8):1810-27. DMZQCEP RU https://pubmed.ncbi.nlm.nih.gov/17378544 DMZQCEP DI DMZQCEP DMZQCEP DN 2-phenylpropoxyadenosine DMZQCEP MI TTM2AOE DMZQCEP MN Adenosine A2a receptor (ADORA2A) DMZQCEP MT DTT DMZQCEP MA Inhibitor DMZQCEP RN Structure-activity relationships of 2,N(6),5'-substituted adenosine derivatives with potent activity at the A2B adenosine receptor. J Med Chem. 2007 Apr 19;50(8):1810-27. DMZQCEP RU https://pubmed.ncbi.nlm.nih.gov/17378544 DMZQCEP DI DMZQCEP DMZQCEP DN 2-phenylpropoxyadenosine DMZQCEP MI TTJFY5U DMZQCEP MN Adenosine A3 receptor (ADORA3) DMZQCEP MT DTT DMZQCEP MA Inhibitor DMZQCEP RN Structure-activity relationships of 2,N(6),5'-substituted adenosine derivatives with potent activity at the A2B adenosine receptor. J Med Chem. 2007 Apr 19;50(8):1810-27. DMZQCEP RU https://pubmed.ncbi.nlm.nih.gov/17378544 DM64JE8 DI DM64JE8 DM64JE8 DN 2-phenylpyrazolo-[1,5-a]pyridine-7-carboxamide DM64JE8 MI TTVDSZ0 DM64JE8 MN Poly [ADP-ribose] polymerase 1 (PARP1) DM64JE8 MT DTT DM64JE8 MA Inhibitor DM64JE8 RN Discovery of 2-{4-[(3S)-piperidin-3-yl]phenyl}-2H-indazole-7-carboxamide (MK-4827): a novel oral poly(ADP-ribose)polymerase (PARP) inhibitor effica... J Med Chem. 2009 Nov 26;52(22):7170-85. DM64JE8 RU https://pubmed.ncbi.nlm.nih.gov/19873981 DMAENRQ DI DMAENRQ DMAENRQ DN 2-phenylquinoline-8-carboxamide DMAENRQ MI TTVDSZ0 DMAENRQ MN Poly [ADP-ribose] polymerase 1 (PARP1) DMAENRQ MT DTT DMAENRQ MA Inhibitor DMAENRQ RN Design, synthesis, and evaluation in vitro of quinoline-8-carboxamides, a new class of poly(adenosine-diphosphate-ribose)polymerase-1 (PARP-1) inhi... J Med Chem. 2009 Feb 12;52(3):868-77. DMAENRQ RU https://pubmed.ncbi.nlm.nih.gov/19117416 DMX6GH5 DI DMX6GH5 DMX6GH5 DN 2-Phosphoglyceric Acid DMX6GH5 MI TTVNA43 DMX6GH5 MN Bacterial Deoxy-D-manno-octulosonate 8-phosphate synthase (Bact kdsA) DMX6GH5 MT DTT DMX6GH5 MA Inhibitor DMX6GH5 RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMX6GH5 RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMX6GH5 DI DMX6GH5 DMX6GH5 DN 2-Phosphoglyceric Acid DMX6GH5 MI TTNS6X4 DMX6GH5 MN Bacterial Triosephosphate isomerase (Bact TPI) DMX6GH5 MT DTT DMX6GH5 MA Inhibitor DMX6GH5 RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMX6GH5 RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMX6GH5 DI DMX6GH5 DMX6GH5 DN 2-Phosphoglyceric Acid DMX6GH5 MI TTHJWVK DMX6GH5 MN Mycobacterium Bisphosphoglycerate phosphoglycerate mutase (MycB gpmI) DMX6GH5 MT DTT DMX6GH5 MA Inhibitor DMX6GH5 RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMX6GH5 RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMO14NH DI DMO14NH DMO14NH DN 2-Phosphoglycolic Acid DMO14NH MI TTNS6X4 DMO14NH MN Bacterial Triosephosphate isomerase (Bact TPI) DMO14NH MT DTT DMO14NH MA Inhibitor DMO14NH RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMO14NH RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMM05AO DI DMM05AO DMM05AO DN 2-Phosphonooxy-pentanedioic acid DMM05AO MI TT9G4N0 DMM05AO MN Glutamate carboxypeptidase II (GCPII) DMM05AO MT DTT DMM05AO MA Inhibitor DMM05AO RN Synthesis and biological evaluation of thiol-based inhibitors of glutamate carboxypeptidase II: discovery of an orally active GCP II inhibitor. J Med Chem. 2003 May 8;46(10):1989-96. DMM05AO RU https://pubmed.ncbi.nlm.nih.gov/12723961 DM742IJ DI DM742IJ DM742IJ DN 2-Piperazin-1-yl-benzonitrile DM742IJ MI TTSQIFT DM742IJ MN 5-HT 1A receptor (HTR1A) DM742IJ MT DTT DM742IJ MA Inhibitor DM742IJ RN Activity of aromatic substituted phenylpiperazines lacking affinity for dopamine binding sites in a preclinical test of antipsychotic efficacy. J Med Chem. 1989 May;32(5):1052-6. DM742IJ RU https://pubmed.ncbi.nlm.nih.gov/2565400 DM742IJ DI DM742IJ DM742IJ DN 2-Piperazin-1-yl-benzonitrile DM742IJ MI TT6MSOK DM742IJ MN 5-HT 1D receptor (HTR1D) DM742IJ MT DTT DM742IJ MA Inhibitor DM742IJ RN Activity of aromatic substituted phenylpiperazines lacking affinity for dopamine binding sites in a preclinical test of antipsychotic efficacy. J Med Chem. 1989 May;32(5):1052-6. DM742IJ RU https://pubmed.ncbi.nlm.nih.gov/2565400 DMQT9OK DI DMQT9OK DMQT9OK DN 2-Piperazin-1-yl-phenol DMQT9OK MI TTSQIFT DMQT9OK MN 5-HT 1A receptor (HTR1A) DMQT9OK MT DTT DMQT9OK MA Inhibitor DMQT9OK RN Synthesis and evaluation of phenyl- and benzoylpiperazines as potential serotonergic agents. J Med Chem. 1986 May;29(5):630-4. DMQT9OK RU https://pubmed.ncbi.nlm.nih.gov/3701781 DMQT9OK DI DMQT9OK DMQT9OK DN 2-Piperazin-1-yl-phenol DMQT9OK MI TT6MSOK DMQT9OK MN 5-HT 1D receptor (HTR1D) DMQT9OK MT DTT DMQT9OK MA Inhibitor DMQT9OK RN Synthesis and evaluation of phenyl- and benzoylpiperazines as potential serotonergic agents. J Med Chem. 1986 May;29(5):630-4. DMQT9OK RU https://pubmed.ncbi.nlm.nih.gov/3701781 DMQT9OK DI DMQT9OK DMQT9OK DN 2-Piperazin-1-yl-phenol DMQT9OK MI TTJQOD7 DMQT9OK MN 5-HT 2A receptor (HTR2A) DMQT9OK MT DTT DMQT9OK MA Inhibitor DMQT9OK RN Synthesis and evaluation of phenyl- and benzoylpiperazines as potential serotonergic agents. J Med Chem. 1986 May;29(5):630-4. DMQT9OK RU https://pubmed.ncbi.nlm.nih.gov/3701781 DM27GZC DI DM27GZC DM27GZC DN 2-PMPA DM27GZC MI TT9G4N0 DM27GZC MN Glutamate carboxypeptidase II (GCPII) DM27GZC MT DTT DM27GZC MA Inhibitor DM27GZC RN Selective inhibition of NAALADase, which converts NAAG to glutamate, reduces ischemic brain injury. Nat Med. 1999 Dec;5(12):1396-402. DM27GZC RU https://pubmed.ncbi.nlm.nih.gov/10581082 DML5O0H DI DML5O0H DML5O0H DN 2-Propanol, Isopropanol DML5O0H MI TTE2KUJ DML5O0H MN Adenosylhomocysteinase (AHCY) DML5O0H MT DTT DML5O0H MA Inhibitor DML5O0H RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DML5O0H RU https://pubmed.ncbi.nlm.nih.gov/10592235 DML5O0H DI DML5O0H DML5O0H DN 2-Propanol, Isopropanol DML5O0H MI TTO8QRU DML5O0H MN Group IIA phospholipase A2 (GIIA sPLA2) DML5O0H MT DTT DML5O0H MA Inhibitor DML5O0H RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DML5O0H RU https://pubmed.ncbi.nlm.nih.gov/10592235 DML5O0H DI DML5O0H DML5O0H DN 2-Propanol, Isopropanol DML5O0H MI TTLSWP6 DML5O0H MN GTP cyclohydrolase-I (GCH1) DML5O0H MT DTT DML5O0H MA Inhibitor DML5O0H RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DML5O0H RU https://pubmed.ncbi.nlm.nih.gov/10592235 DML5O0H DI DML5O0H DML5O0H DN 2-Propanol, Isopropanol DML5O0H MI TTI6V2A DML5O0H MN Heme oxygenase 1 (HMOX1) DML5O0H MT DTT DML5O0H MA Inhibitor DML5O0H RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DML5O0H RU https://pubmed.ncbi.nlm.nih.gov/17139284 DML5O0H DI DML5O0H DML5O0H DN 2-Propanol, Isopropanol DML5O0H MI TTCM4B3 DML5O0H MN Nitric-oxide synthase endothelial (NOS3) DML5O0H MT DTT DML5O0H MA Inhibitor DML5O0H RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DML5O0H RU https://pubmed.ncbi.nlm.nih.gov/17139284 DML5O0H DI DML5O0H DML5O0H DN 2-Propanol, Isopropanol DML5O0H MI TTXA6PH DML5O0H MN Oxysterols receptor LXR-beta (NR1H2) DML5O0H MT DTT DML5O0H MA Inhibitor DML5O0H RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DML5O0H RU https://pubmed.ncbi.nlm.nih.gov/17139284 DML5O0H DI DML5O0H DML5O0H DN 2-Propanol, Isopropanol DML5O0H MI TTF8CQI DML5O0H MN Tumor necrosis factor (TNF) DML5O0H MT DTT DML5O0H MA Inhibitor DML5O0H RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DML5O0H RU https://pubmed.ncbi.nlm.nih.gov/10592235 DMORG3D DI DMORG3D DMORG3D DN 2-Propionyl-1H-indole-6-carboxamidine DMORG3D MI TT2WR1T DMORG3D MN Cationic trypsinogen (PRSS1) DMORG3D MT DTT DMORG3D MA Inhibitor DMORG3D RN Aromatic amidines: comparison of their ability to block respiratory syncytial virus induced cell fusion and to inhibit plasmin, urokinase, thrombin... J Med Chem. 1983 Feb;26(2):294-8. DMORG3D RU https://pubmed.ncbi.nlm.nih.gov/6219223 DMP8J7E DI DMP8J7E DMP8J7E DN 2-Propionyl-cyclohexane-1,3-dione DMP8J7E MI TT8DSFC DMP8J7E MN Hydroxyphenylpyruvate dioxygenase (HPD) DMP8J7E MT DTT DMP8J7E MA Inhibitor DMP8J7E RN SAR studies of 2-o-substituted-benzoyl- and 2-alkanoyl-cyclohexane-1,3-diones as inhibitors of 4-hydroxyphenylpyruvate dioxygenase. Bioorg Med Chem Lett. 2000 May 1;10(9):843-5. DMP8J7E RU https://pubmed.ncbi.nlm.nih.gov/10853644 DMG0I25 DI DMG0I25 DMG0I25 DN 2-propylamido-5-sulfonamidoindane DMG0I25 MI TTHQPL7 DMG0I25 MN Carbonic anhydrase I (CA-I) DMG0I25 MT DTT DMG0I25 MA Inhibitor DMG0I25 RN Indanesulfonamides as carbonic anhydrase inhibitors. Toward structure-based design of selective inhibitors of the tumor-associated isozyme CA IX. J Med Chem. 2006 May 4;49(9):2743-9. DMG0I25 RU https://pubmed.ncbi.nlm.nih.gov/16640335 DMG0I25 DI DMG0I25 DMG0I25 DN 2-propylamido-5-sulfonamidoindane DMG0I25 MI TTANPDJ DMG0I25 MN Carbonic anhydrase II (CA-II) DMG0I25 MT DTT DMG0I25 MA Inhibitor DMG0I25 RN Indanesulfonamides as carbonic anhydrase inhibitors. Toward structure-based design of selective inhibitors of the tumor-associated isozyme CA IX. J Med Chem. 2006 May 4;49(9):2743-9. DMG0I25 RU https://pubmed.ncbi.nlm.nih.gov/16640335 DMG0I25 DI DMG0I25 DMG0I25 DN 2-propylamido-5-sulfonamidoindane DMG0I25 MI TT2LVK8 DMG0I25 MN Carbonic anhydrase IX (CA-IX) DMG0I25 MT DTT DMG0I25 MA Inhibitor DMG0I25 RN Indanesulfonamides as carbonic anhydrase inhibitors. Toward structure-based design of selective inhibitors of the tumor-associated isozyme CA IX. J Med Chem. 2006 May 4;49(9):2743-9. DMG0I25 RU https://pubmed.ncbi.nlm.nih.gov/16640335 DMBW6GA DI DMBW6GA DMBW6GA DN 2-Propyl-beta-carboline-2-ium iodide DMBW6GA MI TT1RS9F DMBW6GA MN Acetylcholinesterase (AChE) DMBW6GA MT DTT DMBW6GA MA Inhibitor DMBW6GA RN Bivalent beta-carbolines as potential multitarget anti-Alzheimer agents. J Med Chem. 2010 May 13;53(9):3611-7. DMBW6GA RU https://pubmed.ncbi.nlm.nih.gov/20361801 DMBW6GA DI DMBW6GA DMBW6GA DN 2-Propyl-beta-carboline-2-ium iodide DMBW6GA MI TTEB0GD DMBW6GA MN Cholinesterase (BCHE) DMBW6GA MT DTT DMBW6GA MA Inhibitor DMBW6GA RN Bivalent beta-carbolines as potential multitarget anti-Alzheimer agents. J Med Chem. 2010 May 13;53(9):3611-7. DMBW6GA RU https://pubmed.ncbi.nlm.nih.gov/20361801 DM1L7PN DI DM1L7PN DM1L7PN DN 2-Propyl-pentanoic acid 4-sulfamoyl-benzyl ester DM1L7PN MI TTZHA0O DM1L7PN MN Carbonic anhydrase IV (CA-IV) DM1L7PN MT DTT DM1L7PN MA Inhibitor DM1L7PN RN Carbonic anhydrase inhibitors: anticonvulsant sulfonamides incorporating valproyl and other lipophilic moieties. J Med Chem. 2002 Jan 17;45(2):312-20. DM1L7PN RU https://pubmed.ncbi.nlm.nih.gov/11784136 DMVWUME DI DMVWUME DMVWUME DN 2-Propyl-pentanoic acid 4-sulfamoyl-benzylamide DMVWUME MI TTZHA0O DMVWUME MN Carbonic anhydrase IV (CA-IV) DMVWUME MT DTT DMVWUME MA Inhibitor DMVWUME RN Carbonic anhydrase inhibitors: anticonvulsant sulfonamides incorporating valproyl and other lipophilic moieties. J Med Chem. 2002 Jan 17;45(2):312-20. DMVWUME RU https://pubmed.ncbi.nlm.nih.gov/11784136 DM1NK2M DI DM1NK2M DM1NK2M DN 2-p-tolyl-2H-pyrazolo[3,4-c]quinolin-4(5H)-one DM1NK2M MI TTK25J1 DM1NK2M MN Adenosine A1 receptor (ADORA1) DM1NK2M MT DTT DM1NK2M MA Inhibitor DM1NK2M RN New 2-arylpyrazolo[3,4-c]quinoline derivatives as potent and selective human A3 adenosine receptor antagonists. Synthesis, pharmacological evaluati... J Med Chem. 2007 Aug 23;50(17):4061-74. DM1NK2M RU https://pubmed.ncbi.nlm.nih.gov/17665891 DM9MIC5 DI DM9MIC5 DM9MIC5 DN 2-p-tolyl-2H-pyrazolo[3,4-c]quinolin-4-amine DM9MIC5 MI TTK25J1 DM9MIC5 MN Adenosine A1 receptor (ADORA1) DM9MIC5 MT DTT DM9MIC5 MA Inhibitor DM9MIC5 RN New 2-arylpyrazolo[3,4-c]quinoline derivatives as potent and selective human A3 adenosine receptor antagonists. Synthesis, pharmacological evaluati... J Med Chem. 2007 Aug 23;50(17):4061-74. DM9MIC5 RU https://pubmed.ncbi.nlm.nih.gov/17665891 DM9MIC5 DI DM9MIC5 DM9MIC5 DN 2-p-tolyl-2H-pyrazolo[3,4-c]quinolin-4-amine DM9MIC5 MI TTM2AOE DM9MIC5 MN Adenosine A2a receptor (ADORA2A) DM9MIC5 MT DTT DM9MIC5 MA Inhibitor DM9MIC5 RN New 2-arylpyrazolo[3,4-c]quinoline derivatives as potent and selective human A3 adenosine receptor antagonists. Synthesis, pharmacological evaluati... J Med Chem. 2007 Aug 23;50(17):4061-74. DM9MIC5 RU https://pubmed.ncbi.nlm.nih.gov/17665891 DM37S5C DI DM37S5C DM37S5C DN 2-p-tolyl-4,5-dihydro-1H-imidazole DM37S5C MI TTGP7BY DM37S5C MN Monoamine oxidase type B (MAO-B) DM37S5C MT DTT DM37S5C MA Inhibitor DM37S5C RN Ultrasound promoted synthesis of 2-imidazolines in water: a greener approach toward monoamine oxidase inhibitors. Bioorg Med Chem Lett. 2009 Jan 15;19(2):546-9. DM37S5C RU https://pubmed.ncbi.nlm.nih.gov/19064321 DMFWA9Y DI DMFWA9Y DMFWA9Y DN 2-p-tolyl-4H-chromen-4-one DMFWA9Y MI TTGP7BY DMFWA9Y MN Monoamine oxidase type B (MAO-B) DMFWA9Y MT DTT DMFWA9Y MA Inhibitor DMFWA9Y RN A new series of flavones, thioflavones, and flavanones as selective monoamine oxidase-B inhibitors. Bioorg Med Chem. 2010 Feb;18(3):1273-9. DMFWA9Y RU https://pubmed.ncbi.nlm.nih.gov/20045650 DM2HKCM DI DM2HKCM DM2HKCM DN 2-p-tolyl-4H-chromene-4-thione DM2HKCM MI TTGP7BY DM2HKCM MN Monoamine oxidase type B (MAO-B) DM2HKCM MT DTT DM2HKCM MA Inhibitor DM2HKCM RN A new series of flavones, thioflavones, and flavanones as selective monoamine oxidase-B inhibitors. Bioorg Med Chem. 2010 Feb;18(3):1273-9. DM2HKCM RU https://pubmed.ncbi.nlm.nih.gov/20045650 DMJIVL3 DI DMJIVL3 DMJIVL3 DN 2-p-Tolyl-6H-pyrazolo[1,5-c]quinazolin-5-one DMJIVL3 MI TT1MPAY DMJIVL3 MN GABA(A) receptor alpha-1 (GABRA1) DMJIVL3 MT DTT DMJIVL3 MA Inhibitor DMJIVL3 RN Synthesis and binding activity of some pyrazolo[1,5-c]quinazolines as tools to verify an optional binding site of a benzodiazepine receptor ligand. J Med Chem. 1996 Jul 19;39(15):2915-21. DMJIVL3 RU https://pubmed.ncbi.nlm.nih.gov/8709126 DMJIVL3 DI DMJIVL3 DMJIVL3 DN 2-p-Tolyl-6H-pyrazolo[1,5-c]quinazolin-5-one DMJIVL3 MI TTNJYV2 DMJIVL3 MN Gamma-aminobutyric acid receptor (GAR) DMJIVL3 MT DTT DMJIVL3 MA Inhibitor DMJIVL3 RN Synthesis and binding activity of some pyrazolo[1,5-c]quinazolines as tools to verify an optional binding site of a benzodiazepine receptor ligand. J Med Chem. 1996 Jul 19;39(15):2915-21. DMJIVL3 RU https://pubmed.ncbi.nlm.nih.gov/8709126 DMLCDZN DI DMLCDZN DMLCDZN DN 2-Pyridin-2-yl-6H-pyrazolo[1,5-c]quinazolin-5-one DMLCDZN MI TT1MPAY DMLCDZN MN GABA(A) receptor alpha-1 (GABRA1) DMLCDZN MT DTT DMLCDZN MA Inhibitor DMLCDZN RN Synthesis and binding activity of some pyrazolo[1,5-c]quinazolines as tools to verify an optional binding site of a benzodiazepine receptor ligand. J Med Chem. 1996 Jul 19;39(15):2915-21. DMLCDZN RU https://pubmed.ncbi.nlm.nih.gov/8709126 DMLCDZN DI DMLCDZN DMLCDZN DN 2-Pyridin-2-yl-6H-pyrazolo[1,5-c]quinazolin-5-one DMLCDZN MI TTNJYV2 DMLCDZN MN Gamma-aminobutyric acid receptor (GAR) DMLCDZN MT DTT DMLCDZN MA Inhibitor DMLCDZN RN Synthesis and binding activity of some pyrazolo[1,5-c]quinazolines as tools to verify an optional binding site of a benzodiazepine receptor ligand. J Med Chem. 1996 Jul 19;39(15):2915-21. DMLCDZN RU https://pubmed.ncbi.nlm.nih.gov/8709126 DMAS46B DI DMAS46B DMAS46B DN 2-Pyridin-2-ylmethyl-1,2-dihydro-indazol-3-one DMAS46B MI TT2J34L DMAS46B MN Arachidonate 5-lipoxygenase (5-LOX) DMAS46B MT DTT DMAS46B MA Inhibitor DMAS46B RN Indazolinones, a new series of redox-active 5-lipoxygenase inhibitors with built-in selectivity and oral activity. J Med Chem. 1991 Mar;34(3):1028-36. DMAS46B RU https://pubmed.ncbi.nlm.nih.gov/1848292 DM7RUNT DI DM7RUNT DM7RUNT DN 2-Pyridin-3-yl-7-aza-bicyclo[2.2.1]heptane DM7RUNT MI TTF4E0J DM7RUNT MN Neuronal acetylcholine receptor alpha-2 (CHRNA2) DM7RUNT MT DTT DM7RUNT MA Inhibitor DM7RUNT RN Epibatidine structure-activity relationships. Bioorg Med Chem Lett. 2004 Apr 19;14(8):1889-96. DM7RUNT RU https://pubmed.ncbi.nlm.nih.gov/15050621 DMT21UX DI DMT21UX DMT21UX DN 2-Pyridin-3-yl-benzo[h]chromen-4-one DMT21UX MI TTK3PY9 DMT21UX MN DNA-dependent protein kinase catalytic (PRKDC) DMT21UX MT DTT DMT21UX MA Inhibitor DMT21UX RN Selective benzopyranone and pyrimido[2,1-a]isoquinolin-4-one inhibitors of DNA-dependent protein kinase: synthesis, structure-activity studies, and... J Med Chem. 2005 Jan 27;48(2):569-85. DMT21UX RU https://pubmed.ncbi.nlm.nih.gov/15658870 DMJYI0P DI DMJYI0P DMJYI0P DN 2-Pyridin-3-ylmethyl-1,2-dihydro-indazol-3-one DMJYI0P MI TT2J34L DMJYI0P MN Arachidonate 5-lipoxygenase (5-LOX) DMJYI0P MT DTT DMJYI0P MA Inhibitor DMJYI0P RN Tumour necrosis factor production in a rat airpouch model of inflammation: role of eicosanoids. Agents Actions. 1991 Mar;32(3-4):289-94. DMJYI0P RU https://pubmed.ncbi.nlm.nih.gov/1650523 DM5D09Q DI DM5D09Q DM5D09Q DN 2-Pyridin-4-yl-1,2,3,4-tetrahydro-isoquinoline DM5D09Q MI TTNGILX DM5D09Q MN Adrenergic receptor alpha-1A (ADRA1A) DM5D09Q MT DTT DM5D09Q MA Inhibitor DM5D09Q RN 4-(3,4-dihydro-1H-isoquinolin-2yl)-pyridines and 4-(3,4-dihydro-1H-isoquinolin-2-yl)-quinolines as potent NR1/2B subtype selective NMDA receptor an... Bioorg Med Chem Lett. 2003 May 19;13(10):1759-62. DM5D09Q RU https://pubmed.ncbi.nlm.nih.gov/12729659 DM5D09Q DI DM5D09Q DM5D09Q DN 2-Pyridin-4-yl-1,2,3,4-tetrahydro-isoquinoline DM5D09Q MI TTBRKXS DM5D09Q MN Adrenergic receptor alpha-1B (ADRA1B) DM5D09Q MT DTT DM5D09Q MA Inhibitor DM5D09Q RN 4-(3,4-dihydro-1H-isoquinolin-2yl)-pyridines and 4-(3,4-dihydro-1H-isoquinolin-2-yl)-quinolines as potent NR1/2B subtype selective NMDA receptor an... Bioorg Med Chem Lett. 2003 May 19;13(10):1759-62. DM5D09Q RU https://pubmed.ncbi.nlm.nih.gov/12729659 DM5D09Q DI DM5D09Q DM5D09Q DN 2-Pyridin-4-yl-1,2,3,4-tetrahydro-isoquinoline DM5D09Q MI TT34BHT DM5D09Q MN Adrenergic receptor alpha-1D (ADRA1D) DM5D09Q MT DTT DM5D09Q MA Inhibitor DM5D09Q RN 4-(3,4-dihydro-1H-isoquinolin-2yl)-pyridines and 4-(3,4-dihydro-1H-isoquinolin-2-yl)-quinolines as potent NR1/2B subtype selective NMDA receptor an... Bioorg Med Chem Lett. 2003 May 19;13(10):1759-62. DM5D09Q RU https://pubmed.ncbi.nlm.nih.gov/12729659 DM5D09Q DI DM5D09Q DM5D09Q DN 2-Pyridin-4-yl-1,2,3,4-tetrahydro-isoquinoline DM5D09Q MI TTLD29N DM5D09Q MN Glutamate receptor ionotropic NMDA 1 (NMDAR1) DM5D09Q MT DTT DM5D09Q MA Inhibitor DM5D09Q RN 4-(3,4-dihydro-1H-isoquinolin-2yl)-pyridines and 4-(3,4-dihydro-1H-isoquinolin-2-yl)-quinolines as potent NR1/2B subtype selective NMDA receptor an... Bioorg Med Chem Lett. 2003 May 19;13(10):1759-62. DM5D09Q RU https://pubmed.ncbi.nlm.nih.gov/12729659 DM5D09Q DI DM5D09Q DM5D09Q DN 2-Pyridin-4-yl-1,2,3,4-tetrahydro-isoquinoline DM5D09Q MI TTN9D8E DM5D09Q MN Glutamate receptor ionotropic NMDA 2B (NMDAR2B) DM5D09Q MT DTT DM5D09Q MA Inhibitor DM5D09Q RN 4-(3,4-dihydro-1H-isoquinolin-2yl)-pyridines and 4-(3,4-dihydro-1H-isoquinolin-2-yl)-quinolines as potent NR1/2B subtype selective NMDA receptor an... Bioorg Med Chem Lett. 2003 May 19;13(10):1759-62. DM5D09Q RU https://pubmed.ncbi.nlm.nih.gov/12729659 DMGB1QU DI DMGB1QU DMGB1QU DN 2-Pyridin-4-ylmethyl-1,2-dihydro-indazol-3-one DMGB1QU MI TT2J34L DMGB1QU MN Arachidonate 5-lipoxygenase (5-LOX) DMGB1QU MT DTT DMGB1QU MA Inhibitor DMGB1QU RN Indazolinones, a new series of redox-active 5-lipoxygenase inhibitors with built-in selectivity and oral activity. J Med Chem. 1991 Mar;34(3):1028-36. DMGB1QU RU https://pubmed.ncbi.nlm.nih.gov/1848292 DMVAQOZ DI DMVAQOZ DMVAQOZ DN 2-Pyridinethiol DMVAQOZ MI TTF2LRI DMVAQOZ MN Cathepsin B (CTSB) DMVAQOZ MT DTT DMVAQOZ MA Inhibitor DMVAQOZ RN DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Nucleic Acids Res. 2011 Jan;39(Database issue):D1035-41. DMVAQOZ RU https://pubmed.ncbi.nlm.nih.gov/21059682 DMN516S DI DMN516S DMN516S DN 2-pyridylethylamine DMN516S MI TTTIBOJ DMN516S MN Histamine H1 receptor (H1R) DMN516S MT DTT DMN516S MA Agonist DMN516S RN Large-scale overproduction, functional purification and ligand affinities of the His-tagged human histamine H1 receptor. Eur J Biochem. 2004 Jul;271(13):2636-46. DMN516S RU https://pubmed.ncbi.nlm.nih.gov/15206929 DMBJXCF DI DMBJXCF DMBJXCF DN 2pyrrolidin-1-yl-1-phenylpentan-1-one DMBJXCF MI TTVBI8W DMBJXCF MN Dopamine transporter (DAT) DMBJXCF MT DTT DMBJXCF MA Inhibitor DMBJXCF RN 1-(4-Methylphenyl)-2-pyrrolidin-1-yl-pentan-1-one (Pyrovalerone) analogues: a promising class of monoamine uptake inhibitors. J Med Chem. 2006 Feb 23;49(4):1420-32. DMBJXCF RU https://pubmed.ncbi.nlm.nih.gov/16480278 DMBJXCF DI DMBJXCF DMBJXCF DN 2pyrrolidin-1-yl-1-phenylpentan-1-one DMBJXCF MI TTAWNKZ DMBJXCF MN Norepinephrine transporter (NET) DMBJXCF MT DTT DMBJXCF MA Inhibitor DMBJXCF RN 1-(4-Methylphenyl)-2-pyrrolidin-1-yl-pentan-1-one (Pyrovalerone) analogues: a promising class of monoamine uptake inhibitors. J Med Chem. 2006 Feb 23;49(4):1420-32. DMBJXCF RU https://pubmed.ncbi.nlm.nih.gov/16480278 DMGPI0C DI DMGPI0C DMGPI0C DN 2-Pyrrolidin-1-yl-benzo[h]chromen-4-one DMGPI0C MI TTK3PY9 DMGPI0C MN DNA-dependent protein kinase catalytic (PRKDC) DMGPI0C MT DTT DMGPI0C MA Inhibitor DMGPI0C RN Selective benzopyranone and pyrimido[2,1-a]isoquinolin-4-one inhibitors of DNA-dependent protein kinase: synthesis, structure-activity studies, and... J Med Chem. 2005 Jan 27;48(2):569-85. DMGPI0C RU https://pubmed.ncbi.nlm.nih.gov/15658870 DMNU1YR DI DMNU1YR DMNU1YR DN 2S,4R-4-METHYLGLUTAMATE DMNU1YR MI TT0MYE2 DMNU1YR MN Glutamate receptor ionotropic kainate 1 (GRIK1) DMNU1YR MT DTT DMNU1YR MA Inhibitor DMNU1YR RN Chemo-enzymatic synthesis of a series of 2,4-syn-functionalized (S)-glutamate analogues: new insight into the structure-activity relation of ionotr... J Med Chem. 2008 Jul 24;51(14):4093-103. DMNU1YR RU https://pubmed.ncbi.nlm.nih.gov/18578478 DMAO7DS DI DMAO7DS DMAO7DS DN 2-Sulfamoyl-benzoic acid methyl ester DMAO7DS MI TTANPDJ DMAO7DS MN Carbonic anhydrase II (CA-II) DMAO7DS MT DTT DMAO7DS MA Inhibitor DMAO7DS RN Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/membrane-associated carbonic anhydrase isozymes I, II, and IX with sulfonamide... J Med Chem. 2005 Mar 24;48(6):2121-5. DMAO7DS RU https://pubmed.ncbi.nlm.nih.gov/15771455 DMAO7DS DI DMAO7DS DMAO7DS DN 2-Sulfamoyl-benzoic acid methyl ester DMAO7DS MI TT2LVK8 DMAO7DS MN Carbonic anhydrase IX (CA-IX) DMAO7DS MT DTT DMAO7DS MA Inhibitor DMAO7DS RN Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/membrane-associated carbonic anhydrase isozymes I, II, and IX with sulfonamide... J Med Chem. 2005 Mar 24;48(6):2121-5. DMAO7DS RU https://pubmed.ncbi.nlm.nih.gov/15771455 DMJBO3D DI DMJBO3D DMJBO3D DN 2-Sulfhydryl-Ethanol DMJBO3D MI TTA7UJC DMJBO3D MN Alpha-1-antitrypsin (SERPINA1) DMJBO3D MT DTT DMJBO3D MA Inhibitor DMJBO3D RN DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Nucleic Acids Res. 2011 Jan;39(Database issue):D1035-41. DMJBO3D RU https://pubmed.ncbi.nlm.nih.gov/21059682 DMJBO3D DI DMJBO3D DMJBO3D DN 2-Sulfhydryl-Ethanol DMJBO3D MI TTU6BFZ DMJBO3D MN Candida Thymidylate synthase (Candi TMP1) DMJBO3D MT DTT DMJBO3D MA Inhibitor DMJBO3D RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMJBO3D RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMJBO3D DI DMJBO3D DMJBO3D DN 2-Sulfhydryl-Ethanol DMJBO3D MI TTUNARX DMJBO3D MN Carbonic anhydrase (CA) DMJBO3D MT DTT DMJBO3D MA Inhibitor DMJBO3D RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMJBO3D RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMJBO3D DI DMJBO3D DMJBO3D DN 2-Sulfhydryl-Ethanol DMJBO3D MI TTANPDJ DMJBO3D MN Carbonic anhydrase II (CA-II) DMJBO3D MT DTT DMJBO3D MA Inhibitor DMJBO3D RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMJBO3D RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMJBO3D DI DMJBO3D DMJBO3D DN 2-Sulfhydryl-Ethanol DMJBO3D MI TTJHKYD DMJBO3D MN Delta-aminolevulinic acid dehydratase (ALAD) DMJBO3D MT DTT DMJBO3D MA Inhibitor DMJBO3D RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMJBO3D RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMJBO3D DI DMJBO3D DMJBO3D DN 2-Sulfhydryl-Ethanol DMJBO3D MI TTGKIED DMJBO3D MN Fibroblast growth factor-2 (FGF2) DMJBO3D MT DTT DMJBO3D MA Inhibitor DMJBO3D RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMJBO3D RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMJBO3D DI DMJBO3D DMJBO3D DN 2-Sulfhydryl-Ethanol DMJBO3D MI TTWQYB7 DMJBO3D MN High mobility group protein B1 (HMGB1) DMJBO3D MT DTT DMJBO3D MA Inhibitor DMJBO3D RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMJBO3D RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMJBO3D DI DMJBO3D DMJBO3D DN 2-Sulfhydryl-Ethanol DMJBO3D MI TTZT9R2 DMJBO3D MN Hydroxysteroid dehydrogenase 3-beta (HSD3B) DMJBO3D MT DTT DMJBO3D MA Inhibitor DMJBO3D RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMJBO3D RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMJBO3D DI DMJBO3D DMJBO3D DN 2-Sulfhydryl-Ethanol DMJBO3D MI TTV9A7R DMJBO3D MN Lactoylglutathione lyase (GLO1) DMJBO3D MT DTT DMJBO3D MA Inhibitor DMJBO3D RN DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Nucleic Acids Res. 2011 Jan;39(Database issue):D1035-41. DMJBO3D RU https://pubmed.ncbi.nlm.nih.gov/21059682 DMJBO3D DI DMJBO3D DMJBO3D DN 2-Sulfhydryl-Ethanol DMJBO3D MI TTR0SWN DMJBO3D MN M-phase inducer phosphatase 2 (MPIP2) DMJBO3D MT DTT DMJBO3D MA Inhibitor DMJBO3D RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMJBO3D RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMJBO3D DI DMJBO3D DMJBO3D DN 2-Sulfhydryl-Ethanol DMJBO3D MI TTYQ4AE DMJBO3D MN Plasmodium Adenylosuccinate synthetase (Malaria Adss) DMJBO3D MT DTT DMJBO3D MA Inhibitor DMJBO3D RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMJBO3D RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMJBO3D DI DMJBO3D DMJBO3D DN 2-Sulfhydryl-Ethanol DMJBO3D MI TT9SL3Q DMJBO3D MN Polypeptide deformylase (PDF) DMJBO3D MT DTT DMJBO3D MA Inhibitor DMJBO3D RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMJBO3D RU https://pubmed.ncbi.nlm.nih.gov/17139284 DM26NKG DI DM26NKG DM26NKG DN 2-tert-butoxy-9H-carbazole DM26NKG MI TTBGTCW DM26NKG MN Kinesin spindle messenger RNA (KIF11 mRNA) DM26NKG MT DTT DM26NKG MA Inhibitor DM26NKG RN Kinesin spindle protein (KSP) inhibitors with 2,3-fused indole scaffolds. J Med Chem. 2010 Jul 8;53(13):5054-8. DM26NKG RU https://pubmed.ncbi.nlm.nih.gov/20521839 DMJBQD8 DI DMJBQD8 DMJBQD8 DN 2-tert-butyl-7-(trifluoromethyl)-9H-carbazole DMJBQD8 MI TTBGTCW DMJBQD8 MN Kinesin spindle messenger RNA (KIF11 mRNA) DMJBQD8 MT DTT DMJBQD8 MA Inhibitor DMJBQD8 RN Kinesin spindle protein (KSP) inhibitors with 2,3-fused indole scaffolds. J Med Chem. 2010 Jul 8;53(13):5054-8. DMJBQD8 RU https://pubmed.ncbi.nlm.nih.gov/20521839 DM6M8Y3 DI DM6M8Y3 DM6M8Y3 DN 2-tert-butyl-9H-carbazole DM6M8Y3 MI TTBGTCW DM6M8Y3 MN Kinesin spindle messenger RNA (KIF11 mRNA) DM6M8Y3 MT DTT DM6M8Y3 MA Inhibitor DM6M8Y3 RN Kinesin spindle protein (KSP) inhibitors with 2,3-fused indole scaffolds. J Med Chem. 2010 Jul 8;53(13):5054-8. DM6M8Y3 RU https://pubmed.ncbi.nlm.nih.gov/20521839 DMNXI1E DI DMNXI1E DMNXI1E DN 2-tert-butylbenzene-1,4-diol DMNXI1E MI TTF4CAM DMNXI1E MN Influenza Hemagglutinin (Influ HA) DMNXI1E MT DTT DMNXI1E MA Inhibitor DMNXI1E RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DMNXI1E RU https://pubmed.ncbi.nlm.nih.gov/10592235 DMFAV5R DI DMFAV5R DMFAV5R DN 2-tert-Butyldimethylsilyloxylycorine DMFAV5R MI TTXV4FI DMFAV5R MN Albendazole monooxygenase (CYP3A4) DMFAV5R MT DTT DMFAV5R MA Inhibitor DMFAV5R RN Selective cytochrome P450 3A4 inhibitory activity of Amaryllidaceae alkaloids. Bioorg Med Chem Lett. 2009 Jun 15;19(12):3233-7. DMFAV5R RU https://pubmed.ncbi.nlm.nih.gov/19428250 DM35JQS DI DM35JQS DM35JQS DN 2-Thiazol-5-ylmethyl-1,2-dihydro-indazol-3-one DM35JQS MI TT2J34L DM35JQS MN Arachidonate 5-lipoxygenase (5-LOX) DM35JQS MT DTT DM35JQS MA Inhibitor DM35JQS RN Indazolinones, a new series of redox-active 5-lipoxygenase inhibitors with built-in selectivity and oral activity. J Med Chem. 1991 Mar;34(3):1028-36. DM35JQS RU https://pubmed.ncbi.nlm.nih.gov/1848292 DMEY9T2 DI DMEY9T2 DMEY9T2 DN 2-Thioethenamine DMEY9T2 MI TT3DQUT DMEY9T2 MN Bacterial Lantibiotic mersacidin (Bact glmM) DMEY9T2 MT DTT DMEY9T2 MA Inhibitor DMEY9T2 RN DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Nucleic Acids Res. 2011 Jan;39(Database issue):D1035-41. DMEY9T2 RU https://pubmed.ncbi.nlm.nih.gov/21059682 DMCEK6N DI DMCEK6N DMCEK6N DN 2-Thiomethyl-3-Phenylpropanoic Acid DMCEK6N MI TT3LJ6G DMCEK6N MN Carboxypeptidase A1 (CPA1) DMCEK6N MT DTT DMCEK6N MA Inhibitor DMCEK6N RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1587). DMCEK6N RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1587 DMCEK6N DI DMCEK6N DMCEK6N DN 2-Thiomethyl-3-Phenylpropanoic Acid DMCEK6N MI TTGA1IV DMCEK6N MN Matrix metalloproteinase-8 (MMP-8) DMCEK6N MT DTT DMCEK6N MA Inhibitor DMCEK6N RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMCEK6N RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMSKNBA DI DMSKNBA DMSKNBA DN 2-Thiomorpholin-4-yl-pyrido[1,2-a]pyrimidin-4-one DMSKNBA MI TTK3PY9 DMSKNBA MN DNA-dependent protein kinase catalytic (PRKDC) DMSKNBA MT DTT DMSKNBA MA Inhibitor DMSKNBA RN Selective benzopyranone and pyrimido[2,1-a]isoquinolin-4-one inhibitors of DNA-dependent protein kinase: synthesis, structure-activity studies, and... J Med Chem. 2005 Jan 27;48(2):569-85. DMSKNBA RU https://pubmed.ncbi.nlm.nih.gov/15658870 DMFXG2E DI DMFXG2E DMFXG2E DN 2-thiomorpholino-4H-benzo[h]chromen-4-one DMFXG2E MI TTK3PY9 DMFXG2E MN DNA-dependent protein kinase catalytic (PRKDC) DMFXG2E MT DTT DMFXG2E MA Inhibitor DMFXG2E RN Discovery of potent chromen-4-one inhibitors of the DNA-dependent protein kinase (DNA-PK) using a small-molecule library approach. J Med Chem. 2005 Dec 1;48(24):7829-46. DMFXG2E RU https://pubmed.ncbi.nlm.nih.gov/16302822 DMPF598 DI DMPF598 DMPF598 DN 2-Thiophen-2-yl-3H-imidazo[4,5-c]quinoline DMPF598 MI TT1MPAY DMPF598 MN GABA(A) receptor alpha-1 (GABRA1) DMPF598 MT DTT DMPF598 MA Inhibitor DMPF598 RN Synthesis and structure--activity relationships of fused imidazopyridines: a new series of benzodiazepine receptor ligands. J Med Chem. 1996 Jul 5;39(14):2844-51. DMPF598 RU https://pubmed.ncbi.nlm.nih.gov/8709114 DMPF598 DI DMPF598 DMPF598 DN 2-Thiophen-2-yl-3H-imidazo[4,5-c]quinoline DMPF598 MI TTZA1NY DMPF598 MN GABA(A) receptor beta-2 (GABRB2) DMPF598 MT DTT DMPF598 MA Inhibitor DMPF598 RN Synthesis and structure--activity relationships of fused imidazopyridines: a new series of benzodiazepine receptor ligands. J Med Chem. 1996 Jul 5;39(14):2844-51. DMPF598 RU https://pubmed.ncbi.nlm.nih.gov/8709114 DMPF598 DI DMPF598 DMPF598 DN 2-Thiophen-2-yl-3H-imidazo[4,5-c]quinoline DMPF598 MI TT06RH5 DMPF598 MN GABA(A) receptor gamma-2 (GABRG2) DMPF598 MT DTT DMPF598 MA Inhibitor DMPF598 RN Synthesis and structure--activity relationships of fused imidazopyridines: a new series of benzodiazepine receptor ligands. J Med Chem. 1996 Jul 5;39(14):2844-51. DMPF598 RU https://pubmed.ncbi.nlm.nih.gov/8709114 DMPF598 DI DMPF598 DMPF598 DN 2-Thiophen-2-yl-3H-imidazo[4,5-c]quinoline DMPF598 MI TTNJYV2 DMPF598 MN Gamma-aminobutyric acid receptor (GAR) DMPF598 MT DTT DMPF598 MA Inhibitor DMPF598 RN Synthesis and structure--activity relationships of fused imidazopyridines: a new series of benzodiazepine receptor ligands. J Med Chem. 1996 Jul 5;39(14):2844-51. DMPF598 RU https://pubmed.ncbi.nlm.nih.gov/8709114 DM4J8B9 DI DM4J8B9 DM4J8B9 DN 2-Thiophen-2-ylmethyl-1,2-dihydro-indazol-3-one DM4J8B9 MI TT2J34L DM4J8B9 MN Arachidonate 5-lipoxygenase (5-LOX) DM4J8B9 MT DTT DM4J8B9 MA Inhibitor DM4J8B9 RN Indazolinones, a new series of redox-active 5-lipoxygenase inhibitors with built-in selectivity and oral activity. J Med Chem. 1991 Mar;34(3):1028-36. DM4J8B9 RU https://pubmed.ncbi.nlm.nih.gov/1848292 DMIEGF4 DI DMIEGF4 DMIEGF4 DN 2-THIOSALVINORIN B DMIEGF4 MI TTQW87Y DMIEGF4 MN Opioid receptor kappa (OPRK1) DMIEGF4 MT DTT DMIEGF4 MA Inhibitor DMIEGF4 RN Convenient synthesis and in vitro pharmacological activity of 2-thioanalogs of salvinorins A and B. Bioorg Med Chem Lett. 2007 Apr 15;17(8):2229-32. DMIEGF4 RU https://pubmed.ncbi.nlm.nih.gov/17303418 DM84R6C DI DM84R6C DM84R6C DN 2-thio-UDP DM84R6C MI TT72OKI DM84R6C MN P2Y purinoceptor 14 (P2RY14) DM84R6C MT DTT DM84R6C MA Agonist DM84R6C RN Human P2Y(14) receptor agonists: truncation of the hexose moiety of uridine-5'-diphosphoglucose and its replacement with alkyl and aryl groups. J Med Chem. 2010 Jan 14;53(1):471-80. DM84R6C RU https://pubmed.ncbi.nlm.nih.gov/19902968 DMJZ5V0 DI DMJZ5V0 DMJZ5V0 DN 2-thioUTP DMJZ5V0 MI TTOZHQC DMJZ5V0 MN P2Y purinoceptor 2 (P2RY2) DMJZ5V0 MT DTT DMJZ5V0 MA Agonist DMJZ5V0 RN Synthesis and structure-activity relationships of uracil nucleotide derivatives and analogues as agonists at human P2Y2, P2Y4, and P2Y6 receptors. J Med Chem. 2006 Nov 30;49(24):7076-87. DMJZ5V0 RU https://pubmed.ncbi.nlm.nih.gov/17125260 DM1HABS DI DM1HABS DM1HABS DN 2-tolyl-6-phenyl-9H-purine DM1HABS MI TTK25J1 DM1HABS MN Adenosine A1 receptor (ADORA1) DM1HABS MT DTT DM1HABS MA Inhibitor DM1HABS RN 2,6-disubstituted and 2,6,8-trisubstituted purines as adenosine receptor antagonists. J Med Chem. 2006 May 18;49(10):2861-7. DM1HABS RU https://pubmed.ncbi.nlm.nih.gov/16686529 DM1HABS DI DM1HABS DM1HABS DN 2-tolyl-6-phenyl-9H-purine DM1HABS MI TTM2AOE DM1HABS MN Adenosine A2a receptor (ADORA2A) DM1HABS MT DTT DM1HABS MA Inhibitor DM1HABS RN 2,6-disubstituted and 2,6,8-trisubstituted purines as adenosine receptor antagonists. J Med Chem. 2006 May 18;49(10):2861-7. DM1HABS RU https://pubmed.ncbi.nlm.nih.gov/16686529 DM1HABS DI DM1HABS DM1HABS DN 2-tolyl-6-phenyl-9H-purine DM1HABS MI TTJFY5U DM1HABS MN Adenosine A3 receptor (ADORA3) DM1HABS MT DTT DM1HABS MA Inhibitor DM1HABS RN 2,6-disubstituted and 2,6,8-trisubstituted purines as adenosine receptor antagonists. J Med Chem. 2006 May 18;49(10):2861-7. DM1HABS RU https://pubmed.ncbi.nlm.nih.gov/16686529 DMOFDVE DI DMOFDVE DMOFDVE DN 2-tosylanthracene-1,4-diol DMOFDVE MI TTRVTMX DMOFDVE MN Bacterial Beta-ketoacyl-ACP synthase III (Bact fabH) DMOFDVE MT DTT DMOFDVE MA Inhibitor DMOFDVE RN Synthesis and biological evaluation of novel sulfonyl-naphthalene-1,4-diols as FabH inhibitors. Bioorg Med Chem Lett. 2008 Dec 15;18(24):6402-5. DMOFDVE RU https://pubmed.ncbi.nlm.nih.gov/18996691 DM8LS6H DI DM8LS6H DM8LS6H DN 2-tosylbenzene-1,4-diol DM8LS6H MI TTRVTMX DM8LS6H MN Bacterial Beta-ketoacyl-ACP synthase III (Bact fabH) DM8LS6H MT DTT DM8LS6H MA Inhibitor DM8LS6H RN Synthesis and biological evaluation of novel sulfonyl-naphthalene-1,4-diols as FabH inhibitors. Bioorg Med Chem Lett. 2008 Dec 15;18(24):6402-5. DM8LS6H RU https://pubmed.ncbi.nlm.nih.gov/18996691 DM2OUG0 DI DM2OUG0 DM2OUG0 DN 2-tosylnaphthalene DM2OUG0 MI TTRVTMX DM2OUG0 MN Bacterial Beta-ketoacyl-ACP synthase III (Bact fabH) DM2OUG0 MT DTT DM2OUG0 MA Inhibitor DM2OUG0 RN Synthesis and biological evaluation of novel sulfonyl-naphthalene-1,4-diols as FabH inhibitors. Bioorg Med Chem Lett. 2008 Dec 15;18(24):6402-5. DM2OUG0 RU https://pubmed.ncbi.nlm.nih.gov/18996691 DM5FHO4 DI DM5FHO4 DM5FHO4 DN 2-Tosylnaphthalene-1,4-diol DM5FHO4 MI TTRVTMX DM5FHO4 MN Bacterial Beta-ketoacyl-ACP synthase III (Bact fabH) DM5FHO4 MT DTT DM5FHO4 MA Inhibitor DM5FHO4 RN Synthesis and biological evaluation of novel sulfonyl-naphthalene-1,4-diols as FabH inhibitors. Bioorg Med Chem Lett. 2008 Dec 15;18(24):6402-5. DM5FHO4 RU https://pubmed.ncbi.nlm.nih.gov/18996691 DMK9OYM DI DMK9OYM DMK9OYM DN 2-tosylnaphthalene-1,4-dione DMK9OYM MI TTRVTMX DMK9OYM MN Bacterial Beta-ketoacyl-ACP synthase III (Bact fabH) DMK9OYM MT DTT DMK9OYM MA Inhibitor DMK9OYM RN Synthesis and biological evaluation of novel sulfonyl-naphthalene-1,4-diols as FabH inhibitors. Bioorg Med Chem Lett. 2008 Dec 15;18(24):6402-5. DMK9OYM RU https://pubmed.ncbi.nlm.nih.gov/18996691 DMVJORE DI DMVJORE DMVJORE DN 2-trityl-4,5-dihydrooxazole DMVJORE MI TTMNI76 DMVJORE MN Calcium-activated potassium channel (KCN) DMVJORE MT DTT DMVJORE MA Inhibitor DMVJORE RN Novel inhibitors of the Gardos channel for the treatment of sickle cell disease. J Med Chem. 2008 Feb 28;51(4):976-82. DMVJORE RU https://pubmed.ncbi.nlm.nih.gov/18232633 DM8XSE3 DI DM8XSE3 DM8XSE3 DN 2-valproylamido-5-sulfonamidoindane DM8XSE3 MI TTHQPL7 DM8XSE3 MN Carbonic anhydrase I (CA-I) DM8XSE3 MT DTT DM8XSE3 MA Inhibitor DM8XSE3 RN Indanesulfonamides as carbonic anhydrase inhibitors. Toward structure-based design of selective inhibitors of the tumor-associated isozyme CA IX. J Med Chem. 2006 May 4;49(9):2743-9. DM8XSE3 RU https://pubmed.ncbi.nlm.nih.gov/16640335 DM8XSE3 DI DM8XSE3 DM8XSE3 DN 2-valproylamido-5-sulfonamidoindane DM8XSE3 MI TTANPDJ DM8XSE3 MN Carbonic anhydrase II (CA-II) DM8XSE3 MT DTT DM8XSE3 MA Inhibitor DM8XSE3 RN Indanesulfonamides as carbonic anhydrase inhibitors. Toward structure-based design of selective inhibitors of the tumor-associated isozyme CA IX. J Med Chem. 2006 May 4;49(9):2743-9. DM8XSE3 RU https://pubmed.ncbi.nlm.nih.gov/16640335 DM8XSE3 DI DM8XSE3 DM8XSE3 DN 2-valproylamido-5-sulfonamidoindane DM8XSE3 MI TT2LVK8 DM8XSE3 MN Carbonic anhydrase IX (CA-IX) DM8XSE3 MT DTT DM8XSE3 MA Inhibitor DM8XSE3 RN Indanesulfonamides as carbonic anhydrase inhibitors. Toward structure-based design of selective inhibitors of the tumor-associated isozyme CA IX. J Med Chem. 2006 May 4;49(9):2743-9. DM8XSE3 RU https://pubmed.ncbi.nlm.nih.gov/16640335 DMOAY8R DI DMOAY8R DMOAY8R DN 3 9-DIHYDRO-N-DESMETHYL-N-ISOPROPYLERYTHROMYCIN A DMOAY8R MI TTQ6VDM DMOAY8R MN Voltage-gated potassium channel Kv11.1 (KCNH2) DMOAY8R MT DTT DMOAY8R MA Inhibitor DMOAY8R RN 9-Dihydroerythromycin ethers as motilin agonists--developing structure-activity relationships for potency and safety. Bioorg Med Chem. 2010 Nov 1;18(21):7651-8. DMOAY8R RU https://pubmed.ncbi.nlm.nih.gov/20869254 DM1L5IJ DI DM1L5IJ DM1L5IJ DN 3 beta-O-acetyloleanolic acid DM1L5IJ MI TT8NGED DM1L5IJ MN Prostaglandin G/H synthase 1 (COX-1) DM1L5IJ MT DTT DM1L5IJ MA Inhibitor DM1L5IJ RN Nitrogen-containing phorbol esters from Croton ciliatoglandulifer and their effects on cyclooxygenases-1 and -2. J Nat Prod. 2006 Jun;69(6):887-90. DM1L5IJ RU https://pubmed.ncbi.nlm.nih.gov/16792405 DM1L5IJ DI DM1L5IJ DM1L5IJ DN 3 beta-O-acetyloleanolic acid DM1L5IJ MI TTVKILB DM1L5IJ MN Prostaglandin G/H synthase 2 (COX-2) DM1L5IJ MT DTT DM1L5IJ MA Inhibitor DM1L5IJ RN Nitrogen-containing phorbol esters from Croton ciliatoglandulifer and their effects on cyclooxygenases-1 and -2. J Nat Prod. 2006 Jun;69(6):887-90. DM1L5IJ RU https://pubmed.ncbi.nlm.nih.gov/16792405 DM491YV DI DM491YV DM491YV DN 3-((1H-imidazol-1-yl)methyl)-9H-xanthen-9-one DM491YV MI TTSZLWK DM491YV MN Aromatase (CYP19A1) DM491YV MT DTT DM491YV MA Inhibitor DM491YV RN Novel highly potent and selective nonsteroidal aromatase inhibitors: synthesis, biological evaluation and structure-activity relationships investigation. J Med Chem. 2010 Jul 22;53(14):5347-51. DM491YV RU https://pubmed.ncbi.nlm.nih.gov/20568782 DMZ9L6Q DI DMZ9L6Q DMZ9L6Q DN 3-((1H-imidazol-1-yl)methyl)aniline DMZ9L6Q MI TTIQUX7 DMZ9L6Q MN Steroid 11-beta-hydroxylase (CYP11B1) DMZ9L6Q MT DTT DMZ9L6Q MA Inhibitor DMZ9L6Q RN Synthesis, biological evaluation, and molecular modeling of 1-benzyl-1H-imidazoles as selective inhibitors of aldosterone synthase (CYP11B2). J Med Chem. 2010 Feb 25;53(4):1712-25. DMZ9L6Q RU https://pubmed.ncbi.nlm.nih.gov/20121113 DMJ6O43 DI DMJ6O43 DMJ6O43 DN 3-((1H-imidazol-4-yl)methyl)pyridine DMJ6O43 MI TT9JNIC DMJ6O43 MN Histamine H3 receptor (H3R) DMJ6O43 MT DTT DMJ6O43 MA Inhibitor DMJ6O43 RN Investigation of the histamine H3 receptor binding site. Design and synthesis of hybrid agonists with a lipophilic side chain. J Med Chem. 2010 Sep 9;53(17):6445-56. DMJ6O43 RU https://pubmed.ncbi.nlm.nih.gov/20690643 DMSGX7V DI DMSGX7V DMSGX7V DN 3-((2-Pyrrolidine-1-yl)-ethyl)uracil DMSGX7V MI TTMCF1Y DMSGX7V MN Purine nucleoside phosphorylase (PNP) DMSGX7V MT DTT DMSGX7V MA Inhibitor DMSGX7V RN Exploring new inhibitors of Plasmodium falciparum purine nucleoside phosphorylase. Eur J Med Chem. 2010 Nov;45(11):5140-9. DMSGX7V RU https://pubmed.ncbi.nlm.nih.gov/20817362 DMJZK40 DI DMJZK40 DMJZK40 DN 3-((3,5-diamino-1H-pyrazol-4-yl)diazenyl)phenol DMJZK40 MI TTAMQ62 DMJZK40 MN Cyclin A2 (CCNA2) DMJZK40 MT DTT DMJZK40 MA Inhibitor DMJZK40 RN 4-arylazo-3,5-diamino-1H-pyrazole CDK inhibitors: SAR study, crystal structure in complex with CDK2, selectivity, and cellular effects. J Med Chem. 2006 Nov 2;49(22):6500-9. DMJZK40 RU https://pubmed.ncbi.nlm.nih.gov/17064068 DMJZK40 DI DMJZK40 DMJZK40 DN 3-((3,5-diamino-1H-pyrazol-4-yl)diazenyl)phenol DMJZK40 MI TT7HF4W DMJZK40 MN Cyclin-dependent kinase 2 (CDK2) DMJZK40 MT DTT DMJZK40 MA Inhibitor DMJZK40 RN 4-arylazo-3,5-diamino-1H-pyrazole CDK inhibitors: SAR study, crystal structure in complex with CDK2, selectivity, and cellular effects. J Med Chem. 2006 Nov 2;49(22):6500-9. DMJZK40 RU https://pubmed.ncbi.nlm.nih.gov/17064068 DMJZK40 DI DMJZK40 DMJZK40 DN 3-((3,5-diamino-1H-pyrazol-4-yl)diazenyl)phenol DMJZK40 MI TT1LVF2 DMJZK40 MN Cyclin-dependent kinase 9 (CDK9) DMJZK40 MT DTT DMJZK40 MA Inhibitor DMJZK40 RN 4-arylazo-3,5-diamino-1H-pyrazole CDK inhibitors: SAR study, crystal structure in complex with CDK2, selectivity, and cellular effects. J Med Chem. 2006 Nov 2;49(22):6500-9. DMJZK40 RU https://pubmed.ncbi.nlm.nih.gov/17064068 DMJZK40 DI DMJZK40 DMJZK40 DN 3-((3,5-diamino-1H-pyrazol-4-yl)diazenyl)phenol DMJZK40 MI TTCEJ4F DMJZK40 MN G1/S-specific cyclin-E1 (CCNE1) DMJZK40 MT DTT DMJZK40 MA Inhibitor DMJZK40 RN 4-arylazo-3,5-diamino-1H-pyrazole CDK inhibitors: SAR study, crystal structure in complex with CDK2, selectivity, and cellular effects. J Med Chem. 2006 Nov 2;49(22):6500-9. DMJZK40 RU https://pubmed.ncbi.nlm.nih.gov/17064068 DME3079 DI DME3079 DME3079 DN 3-((3-bromothiophen-2-yl)methylene)indolin-2-one DME3079 MI TTUTJGQ DME3079 MN Vascular endothelial growth factor receptor 2 (KDR) DME3079 MT DTT DME3079 MA Inhibitor DME3079 RN Pharmacophore modeling and in silico screening for new KDR kinase inhibitors. Bioorg Med Chem Lett. 2007 Apr 15;17(8):2126-33. DME3079 RU https://pubmed.ncbi.nlm.nih.gov/17306530 DM37X04 DI DM37X04 DM37X04 DN 3-((4-aminophenyl)diazenyl)benzenesulfonamide DM37X04 MI TTANPDJ DM37X04 MN Carbonic anhydrase II (CA-II) DM37X04 MT DTT DM37X04 MA Inhibitor DM37X04 RN Carbonic anhydrase inhibitors. Inhibition of the Rv1284 and Rv3273 beta-carbonic anhydrases from Mycobacterium tuberculosis with diazenylbenzenesul... Bioorg Med Chem Lett. 2009 Sep 1;19(17):4929-32. DM37X04 RU https://pubmed.ncbi.nlm.nih.gov/19651511 DM37X04 DI DM37X04 DM37X04 DN 3-((4-aminophenyl)diazenyl)benzenesulfonamide DM37X04 MI TT2LVK8 DM37X04 MN Carbonic anhydrase IX (CA-IX) DM37X04 MT DTT DM37X04 MA Inhibitor DM37X04 RN Carbonic anhydrase inhibitors. Diazenylbenzenesulfonamides are potent and selective inhibitors of the tumor-associated isozymes IX and XII over the... Bioorg Med Chem. 2009 Oct 15;17(20):7093-9. DM37X04 RU https://pubmed.ncbi.nlm.nih.gov/19773173 DM37X04 DI DM37X04 DM37X04 DN 3-((4-aminophenyl)diazenyl)benzenesulfonamide DM37X04 MI TTSYM0R DM37X04 MN Carbonic anhydrase XII (CA-XII) DM37X04 MT DTT DM37X04 MA Inhibitor DM37X04 RN Carbonic anhydrase inhibitors. Diazenylbenzenesulfonamides are potent and selective inhibitors of the tumor-associated isozymes IX and XII over the... Bioorg Med Chem. 2009 Oct 15;17(20):7093-9. DM37X04 RU https://pubmed.ncbi.nlm.nih.gov/19773173 DMAPZQW DI DMAPZQW DMAPZQW DN 3-((4-hydroxyphenyl)diazenyl)benzenesulfonamide DMAPZQW MI TTANPDJ DMAPZQW MN Carbonic anhydrase II (CA-II) DMAPZQW MT DTT DMAPZQW MA Inhibitor DMAPZQW RN Carbonic anhydrase inhibitors. Inhibition of the Rv1284 and Rv3273 beta-carbonic anhydrases from Mycobacterium tuberculosis with diazenylbenzenesul... Bioorg Med Chem Lett. 2009 Sep 1;19(17):4929-32. DMAPZQW RU https://pubmed.ncbi.nlm.nih.gov/19651511 DMAPZQW DI DMAPZQW DMAPZQW DN 3-((4-hydroxyphenyl)diazenyl)benzenesulfonamide DMAPZQW MI TT2LVK8 DMAPZQW MN Carbonic anhydrase IX (CA-IX) DMAPZQW MT DTT DMAPZQW MA Inhibitor DMAPZQW RN Carbonic anhydrase inhibitors. Diazenylbenzenesulfonamides are potent and selective inhibitors of the tumor-associated isozymes IX and XII over the... Bioorg Med Chem. 2009 Oct 15;17(20):7093-9. DMAPZQW RU https://pubmed.ncbi.nlm.nih.gov/19773173 DMAPZQW DI DMAPZQW DMAPZQW DN 3-((4-hydroxyphenyl)diazenyl)benzenesulfonamide DMAPZQW MI TTSYM0R DMAPZQW MN Carbonic anhydrase XII (CA-XII) DMAPZQW MT DTT DMAPZQW MA Inhibitor DMAPZQW RN Carbonic anhydrase inhibitors. Diazenylbenzenesulfonamides are potent and selective inhibitors of the tumor-associated isozymes IX and XII over the... Bioorg Med Chem. 2009 Oct 15;17(20):7093-9. DMAPZQW RU https://pubmed.ncbi.nlm.nih.gov/19773173 DMAO64J DI DMAO64J DMAO64J DN 3-((E)-Styryl)-quinoline DMAO64J MI TT8FYO9 DMAO64J MN Platelet-derived growth factor receptor alpha (PDGFRA) DMAO64J MT DTT DMAO64J MA Inhibitor DMAO64J RN A new series of PDGF receptor tyrosine kinase inhibitors: 3-substituted quinoline derivatives. J Med Chem. 1994 Jul 8;37(14):2129-37. DMAO64J RU https://pubmed.ncbi.nlm.nih.gov/8035419 DMAO64J DI DMAO64J DMAO64J DN 3-((E)-Styryl)-quinoline DMAO64J MI TTI7421 DMAO64J MN Platelet-derived growth factor receptor beta (PDGFRB) DMAO64J MT DTT DMAO64J MA Inhibitor DMAO64J RN A new series of PDGF receptor tyrosine kinase inhibitors: 3-substituted quinoline derivatives. J Med Chem. 1994 Jul 8;37(14):2129-37. DMAO64J RU https://pubmed.ncbi.nlm.nih.gov/8035419 DMZU74I DI DMZU74I DMZU74I DN 3-((S)-Azetidin-2-yloxy)-5-iodo-pyridine DMZU74I MI TTF4E0J DMZU74I MN Neuronal acetylcholine receptor alpha-2 (CHRNA2) DMZU74I MT DTT DMZU74I MA Inhibitor DMZU74I RN Pharmacology of the agonist binding sites of rat neuronal nicotinic receptor subtypes expressed in HEK 293 cells. Bioorg Med Chem Lett. 2004 Apr 19;14(8):1845-8. DMZU74I RU https://pubmed.ncbi.nlm.nih.gov/15050613 DM57ZMJ DI DM57ZMJ DM57ZMJ DN 3-(1,1-Dimethyl-2-phenyl-ethyl)-pyridine DM57ZMJ MI TTIQUX7 DM57ZMJ MN Steroid 11-beta-hydroxylase (CYP11B1) DM57ZMJ MT DTT DM57ZMJ MA Inhibitor DM57ZMJ RN Structure-activity relationship study of the inhibition of adrenal cortical 11 beta-hydroxylase by new metyrapone analogues. J Med Chem. 1984 Jan;27(1):15-9. DM57ZMJ RU https://pubmed.ncbi.nlm.nih.gov/6606707 DMTDB62 DI DMTDB62 DMTDB62 DN 3-(1,2,3,6-Tetrahydro-pyridin-4-yl)-1H-indole DMTDB62 MI TTSQIFT DMTDB62 MN 5-HT 1A receptor (HTR1A) DMTDB62 MT DTT DMTDB62 MA Inhibitor DMTDB62 RN 3-(1,2,5,6-Tetrahydropyrid-4-yl)pyrrolo[3,2-b]pyrid-5-one: a potent and selective serotonin (5-HT1B) agonist and rotationally restricted phenolic a... J Med Chem. 1990 Aug;33(8):2087-93. DMTDB62 RU https://pubmed.ncbi.nlm.nih.gov/2374139 DM5UL3F DI DM5UL3F DM5UL3F DN 3'-(1,2,3-Triazol-1-yl)-3'-deoxy-beta-D-thymidine DM5UL3F MI TTP3QRF DM5UL3F MN Thymidine kinase 1 (TK1) DM5UL3F MT DTT DM5UL3F MA Inhibitor DM5UL3F RN 3'-[4-Aryl-(1,2,3-triazol-1-yl)]-3'-deoxythymidine analogues as potent and selective inhibitors of human mitochondrial thymidine kinase. J Med Chem. 2010 Apr 8;53(7):2902-12. DM5UL3F RU https://pubmed.ncbi.nlm.nih.gov/20218622 DMXZBQL DI DMXZBQL DMXZBQL DN 3-(1,2-dihydroacenaphthylen-3-yl)pyridine DMXZBQL MI TTIQUX7 DMXZBQL MN Steroid 11-beta-hydroxylase (CYP11B1) DMXZBQL MT DTT DMXZBQL MA Inhibitor DMXZBQL RN Development and evaluation of a pharmacophore model for inhibitors of aldosterone synthase (CYP11B2). Bioorg Med Chem Lett. 2006 Jan 1;16(1):25-30. DMXZBQL RU https://pubmed.ncbi.nlm.nih.gov/16246562 DMHB4PA DI DMHB4PA DMHB4PA DN 3-(1,2-dihydroacenaphthylen-5-yl)pyridine DMHB4PA MI TTIQUX7 DMHB4PA MN Steroid 11-beta-hydroxylase (CYP11B1) DMHB4PA MT DTT DMHB4PA MA Inhibitor DMHB4PA RN Development and evaluation of a pharmacophore model for inhibitors of aldosterone synthase (CYP11B2). Bioorg Med Chem Lett. 2006 Jan 1;16(1):25-30. DMHB4PA RU https://pubmed.ncbi.nlm.nih.gov/16246562 DMQC168 DI DMQC168 DMQC168 DN 3-(1,3 dodecadiynyl)-6-oxiranebutanoic acid DMQC168 MI TTPADOQ DMQC168 MN HMG-CoA reductase (HMGCR) DMQC168 MT DTT DMQC168 MA Inhibitor DMQC168 RN Novel Acetylenic Acids from the Root Bark of Paramacrolobium caeruleum: Inhibitors of 3-Hydroxy-3-methyl-glutaryl Coenzyme A Reductase J. Nat. Prod. 52(1):153-161 (1989). DMQC168 RU http://pubs.acs.org/doi/abs/10.1021/np50061a020 DM24BG6 DI DM24BG6 DM24BG6 DN 3-(1,5-naphthyridin-3-yl)benzonitrile DM24BG6 MI TTHS256 DM24BG6 MN Metabotropic glutamate receptor 5 (mGluR5) DM24BG6 MT DTT DM24BG6 MA Inhibitor DM24BG6 RN Synthesis and SAR comparison of regioisomeric aryl naphthyridines as potent mGlu5 receptor antagonists. Bioorg Med Chem Lett. 2007 Dec 1;17(23):6525-8. DM24BG6 RU https://pubmed.ncbi.nlm.nih.gov/17936624 DMSP4N5 DI DMSP4N5 DMSP4N5 DN 3-(1,8-naphthyridin-2-yl)benzonitrile DMSP4N5 MI TTHS256 DMSP4N5 MN Metabotropic glutamate receptor 5 (mGluR5) DMSP4N5 MT DTT DMSP4N5 MA Inhibitor DMSP4N5 RN Synthesis and SAR comparison of regioisomeric aryl naphthyridines as potent mGlu5 receptor antagonists. Bioorg Med Chem Lett. 2007 Dec 1;17(23):6525-8. DMSP4N5 RU https://pubmed.ncbi.nlm.nih.gov/17936624 DMSZLNE DI DMSZLNE DMSZLNE DN 3'-(1-Benzothien-2-yl)biphenyl-3-ol DMSZLNE MI TTIWB6L DMSZLNE MN Estradiol 17 beta-dehydrogenase 1 (17-beta-HSD1) DMSZLNE MT DTT DMSZLNE MA Inhibitor DMSZLNE RN Novel estrone mimetics with high 17beta-HSD1 inhibitory activity. Bioorg Med Chem. 2010 May 15;18(10):3494-505. DMSZLNE RU https://pubmed.ncbi.nlm.nih.gov/20413314 DMGYDEK DI DMGYDEK DMGYDEK DN 3-(1-Benzyl-1H-imidazol-5-yl)-1-propanol DMGYDEK MI TTIQUX7 DMGYDEK MN Steroid 11-beta-hydroxylase (CYP11B1) DMGYDEK MT DTT DMGYDEK MA Inhibitor DMGYDEK RN Synthesis, biological evaluation, and molecular modeling of 1-benzyl-1H-imidazoles as selective inhibitors of aldosterone synthase (CYP11B2). J Med Chem. 2010 Feb 25;53(4):1712-25. DMGYDEK RU https://pubmed.ncbi.nlm.nih.gov/20121113 DMGDN93 DI DMGDN93 DMGDN93 DN 3-(1-Benzyl-piperidin-3-yl)-2-phenyl-1H-indole DMGDN93 MI TTQ6VDM DMGDN93 MN Voltage-gated potassium channel Kv11.1 (KCNH2) DMGDN93 MT DTT DMGDN93 MA Inhibitor DMGDN93 RN 3-(4-Fluoropiperidin-3-yl)-2-phenylindoles as high affinity, selective, and orally bioavailable h5-HT(2A) receptor antagonists. J Med Chem. 2001 May 10;44(10):1603-14. DMGDN93 RU https://pubmed.ncbi.nlm.nih.gov/11334570 DMWP0VK DI DMWP0VK DMWP0VK DN 3-(1-Benzyl-piperidin-4-yl)-2-phenyl-1H-indole DMWP0VK MI TTJQOD7 DMWP0VK MN 5-HT 2A receptor (HTR2A) DMWP0VK MT DTT DMWP0VK MA Inhibitor DMWP0VK RN 3-(4-Piperidinyl)- and 3-(8-aza-bicyclo[3.2.1]oct-3-yl)-2-phenyl-1H-indoles as bioavailable h5-HT2A antagonists. Bioorg Med Chem Lett. 2000 Dec 18;10(24):2701-3. DMWP0VK RU https://pubmed.ncbi.nlm.nih.gov/11133072 DM2YKHI DI DM2YKHI DM2YKHI DN 3-(1-benzylpiperidin-4-yl)-5-chloro-1H-indole DM2YKHI MI TTNT7K8 DM2YKHI MN Nociceptin receptor (OPRL1) DM2YKHI MT DTT DM2YKHI MA Inhibitor DM2YKHI RN 3-(4-Piperidinyl)indoles and 3-(4-piperidinyl)pyrrolo-[2,3-b]pyridines as ligands for the ORL-1 receptor. Bioorg Med Chem Lett. 2006 Jul 1;16(13):3524-8. DM2YKHI RU https://pubmed.ncbi.nlm.nih.gov/16632355 DM2YKHI DI DM2YKHI DM2YKHI DN 3-(1-benzylpiperidin-4-yl)-5-chloro-1H-indole DM2YKHI MI TTQW87Y DM2YKHI MN Opioid receptor kappa (OPRK1) DM2YKHI MT DTT DM2YKHI MA Inhibitor DM2YKHI RN 3-(4-Piperidinyl)indoles and 3-(4-piperidinyl)pyrrolo-[2,3-b]pyridines as ligands for the ORL-1 receptor. Bioorg Med Chem Lett. 2006 Jul 1;16(13):3524-8. DM2YKHI RU https://pubmed.ncbi.nlm.nih.gov/16632355 DM2YKHI DI DM2YKHI DM2YKHI DN 3-(1-benzylpiperidin-4-yl)-5-chloro-1H-indole DM2YKHI MI TTKWM86 DM2YKHI MN Opioid receptor mu (MOP) DM2YKHI MT DTT DM2YKHI MA Inhibitor DM2YKHI RN 3-(4-Piperidinyl)indoles and 3-(4-piperidinyl)pyrrolo-[2,3-b]pyridines as ligands for the ORL-1 receptor. Bioorg Med Chem Lett. 2006 Jul 1;16(13):3524-8. DM2YKHI RU https://pubmed.ncbi.nlm.nih.gov/16632355 DMG3A4Z DI DMG3A4Z DMG3A4Z DN 3-(1-benzylpiperidin-4-yloxy)benzamide DMG3A4Z MI TTQW87Y DMG3A4Z MN Opioid receptor kappa (OPRK1) DMG3A4Z MT DTT DMG3A4Z MA Inhibitor DMG3A4Z RN Discovery of 8-azabicyclo[3.2.1]octan-3-yloxy-benzamides as selective antagonists of the kappa opioid receptor. Part 1. Bioorg Med Chem Lett. 2010 Oct 1;20(19):5847-52. DMG3A4Z RU https://pubmed.ncbi.nlm.nih.gov/20727752 DMOMSTN DI DMOMSTN DMOMSTN DN 3-(1-carbamoyl-1,1-diphenylmethyl)-1-(4-methoxyphenylethyl)pyrrolidine (APP) DMOMSTN MI TTQ13Z5 DMOMSTN MN Muscarinic acetylcholine receptor M3 (CHRM3) DMOMSTN MT DTT DMOMSTN MA Antagonist DMOMSTN RN Signal transduction underlying carbachol-induced contraction of human urinary bladder. J Pharmacol Exp Ther. 2004 Jun;309(3):1148-53. DMOMSTN RU https://pubmed.ncbi.nlm.nih.gov/14769832 DMHPYWM DI DMHPYWM DMHPYWM DN 3-(1-carboxy-4-mercaptobutoxy)benzoic acid DMHPYWM MI TT9G4N0 DMHPYWM MN Glutamate carboxypeptidase II (GCPII) DMHPYWM MT DTT DMHPYWM MA Inhibitor DMHPYWM RN Structural optimization of thiol-based inhibitors of glutamate carboxypeptidase II by modification of the P1' side chain. J Med Chem. 2006 May 18;49(10):2876-85. DMHPYWM RU https://pubmed.ncbi.nlm.nih.gov/16686531 DMLH7YI DI DMLH7YI DMLH7YI DN 3-(1-Chloro-7-methoxy-naphthalen-2-yl)-pyridine DMLH7YI MI TTIQUX7 DMLH7YI MN Steroid 11-beta-hydroxylase (CYP11B1) DMLH7YI MT DTT DMLH7YI MA Inhibitor DMLH7YI RN Heteroaryl-substituted naphthalenes and structurally modified derivatives: selective inhibitors of CYP11B2 for the treatment of congestive heart fa... J Med Chem. 2005 Oct 20;48(21):6632-42. DMLH7YI RU https://pubmed.ncbi.nlm.nih.gov/16220979 DMLH7YI DI DMLH7YI DMLH7YI DN 3-(1-Chloro-7-methoxy-naphthalen-2-yl)-pyridine DMLH7YI MI TTRA5BZ DMLH7YI MN Steroid 17-alpha-monooxygenase (S17AH) DMLH7YI MT DTT DMLH7YI MA Inhibitor DMLH7YI RN Heteroaryl-substituted naphthalenes and structurally modified derivatives: selective inhibitors of CYP11B2 for the treatment of congestive heart fa... J Med Chem. 2005 Oct 20;48(21):6632-42. DMLH7YI RU https://pubmed.ncbi.nlm.nih.gov/16220979 DMR7M82 DI DMR7M82 DMR7M82 DN 3-(1-ethyl-3,4-dihydronaphthalen-2-yl)-pyridine DMR7M82 MI TTSZLWK DMR7M82 MN Aromatase (CYP19A1) DMR7M82 MT DTT DMR7M82 MA Inhibitor DMR7M82 RN Synthesis and evaluation of heteroaryl-substituted dihydronaphthalenes and indenes: potent and selective inhibitors of aldosterone synthase (CYP11B... J Med Chem. 2006 Apr 6;49(7):2222-31. DMR7M82 RU https://pubmed.ncbi.nlm.nih.gov/16570918 DMR7M82 DI DMR7M82 DMR7M82 DN 3-(1-ethyl-3,4-dihydronaphthalen-2-yl)-pyridine DMR7M82 MI TTIQUX7 DMR7M82 MN Steroid 11-beta-hydroxylase (CYP11B1) DMR7M82 MT DTT DMR7M82 MA Inhibitor DMR7M82 RN Synthesis and evaluation of heteroaryl-substituted dihydronaphthalenes and indenes: potent and selective inhibitors of aldosterone synthase (CYP11B... J Med Chem. 2006 Apr 6;49(7):2222-31. DMR7M82 RU https://pubmed.ncbi.nlm.nih.gov/16570918 DMR7M82 DI DMR7M82 DMR7M82 DN 3-(1-ethyl-3,4-dihydronaphthalen-2-yl)-pyridine DMR7M82 MI TTRA5BZ DMR7M82 MN Steroid 17-alpha-monooxygenase (S17AH) DMR7M82 MT DTT DMR7M82 MA Inhibitor DMR7M82 RN Synthesis and evaluation of heteroaryl-substituted dihydronaphthalenes and indenes: potent and selective inhibitors of aldosterone synthase (CYP11B... J Med Chem. 2006 Apr 6;49(7):2222-31. DMR7M82 RU https://pubmed.ncbi.nlm.nih.gov/16570918 DMERZHK DI DMERZHK DMERZHK DN 3-(1H-Imidazol-4-yl)benzenethiol DMERZHK MI TTZJYKH DMERZHK MN Indoleamine 2,3-dioxygenase 1 (IDO1) DMERZHK MT DTT DMERZHK MA Inhibitor DMERZHK RN Structure based development of phenylimidazole-derived inhibitors of indoleamine 2,3-dioxygenase. J Med Chem. 2008 Aug 28;51(16):4968-77. DMERZHK RU https://pubmed.ncbi.nlm.nih.gov/18665584 DM9ZDIK DI DM9ZDIK DM9ZDIK DN 3-(1H-inden-2-yl)pyridine DM9ZDIK MI TTIQUX7 DM9ZDIK MN Steroid 11-beta-hydroxylase (CYP11B1) DM9ZDIK MT DTT DM9ZDIK MA Inhibitor DM9ZDIK RN Synthesis and evaluation of heteroaryl-substituted dihydronaphthalenes and indenes: potent and selective inhibitors of aldosterone synthase (CYP11B... J Med Chem. 2006 Apr 6;49(7):2222-31. DM9ZDIK RU https://pubmed.ncbi.nlm.nih.gov/16570918 DMLV80B DI DMLV80B DMLV80B DN 3-(1H-indol-1-yl)-N-methyl-3-phenylpropan-1-amine DMLV80B MI TTAWNKZ DMLV80B MN Norepinephrine transporter (NET) DMLV80B MT DTT DMLV80B MA Inhibitor DMLV80B RN Synthesis and activity of novel 1- or 3-(3-amino-1-phenyl propyl)-1,3-dihydro-2H-benzimidazol-2-ones as selective norepinephrine reuptake inhibitors. Bioorg Med Chem Lett. 2008 Dec 1;18(23):6067-70. DMLV80B RU https://pubmed.ncbi.nlm.nih.gov/18951020 DMLV80B DI DMLV80B DMLV80B DN 3-(1H-indol-1-yl)-N-methyl-3-phenylpropan-1-amine DMLV80B MI TT3ROYC DMLV80B MN Serotonin transporter (SERT) DMLV80B MT DTT DMLV80B MA Inhibitor DMLV80B RN Synthesis and activity of novel 1- or 3-(3-amino-1-phenyl propyl)-1,3-dihydro-2H-benzimidazol-2-ones as selective norepinephrine reuptake inhibitors. Bioorg Med Chem Lett. 2008 Dec 1;18(23):6067-70. DMLV80B RU https://pubmed.ncbi.nlm.nih.gov/18951020 DMS3JCN DI DMS3JCN DMS3JCN DN 3-(1H-Indol-2-yl)-1H-quinolin-2-one DMS3JCN MI TTTU902 DMS3JCN MN Checkpoint kinase-1 (CHK1) DMS3JCN MT DTT DMS3JCN MA Inhibitor DMS3JCN RN Development of 6-substituted indolylquinolinones as potent Chek1 kinase inhibitors. Bioorg Med Chem Lett. 2006 Nov 15;16(22):5907-12. DMS3JCN RU https://pubmed.ncbi.nlm.nih.gov/16990002 DMS3JCN DI DMS3JCN DMS3JCN DN 3-(1H-Indol-2-yl)-1H-quinolin-2-one DMS3JCN MI TTUTJGQ DMS3JCN MN Vascular endothelial growth factor receptor 2 (KDR) DMS3JCN MT DTT DMS3JCN MA Inhibitor DMS3JCN RN Optimization of the indolyl quinolinone class of KDR (VEGFR-2) kinase inhibitors: effects of 5-amido- and 5-sulphonamido-indolyl groups on pharmaco... Bioorg Med Chem Lett. 2004 Jan 19;14(2):351-5. DMS3JCN RU https://pubmed.ncbi.nlm.nih.gov/14698157 DMP0RYB DI DMP0RYB DMP0RYB DN 3-(1H-Indol-3-yl)-4-phenylamino-pyrrole-2,5-dione DMP0RYB MI TTFJ8Q1 DMP0RYB MN Protein kinase C alpha (PRKCA) DMP0RYB MT DTT DMP0RYB MA Inhibitor DMP0RYB RN Synthesis of anilino-monoindolylmaleimides as potent and selective PKCbeta inhibitors. Bioorg Med Chem Lett. 2004 Oct 18;14(20):5171-4. DMP0RYB RU https://pubmed.ncbi.nlm.nih.gov/15380221 DMP0RYB DI DMP0RYB DMP0RYB DN 3-(1H-Indol-3-yl)-4-phenylamino-pyrrole-2,5-dione DMP0RYB MI TTYPXQF DMP0RYB MN Protein kinase C beta (PRKCB) DMP0RYB MT DTT DMP0RYB MA Inhibitor DMP0RYB RN Synthesis of anilino-monoindolylmaleimides as potent and selective PKCbeta inhibitors. Bioorg Med Chem Lett. 2004 Oct 18;14(20):5171-4. DMP0RYB RU https://pubmed.ncbi.nlm.nih.gov/15380221 DMSGCKU DI DMSGCKU DMSGCKU DN 3-(1H-Indol-3-yl)-6,7-dimethoxy-quinoline DMSGCKU MI TT8FYO9 DMSGCKU MN Platelet-derived growth factor receptor alpha (PDGFRA) DMSGCKU MT DTT DMSGCKU MA Inhibitor DMSGCKU RN A new series of PDGF receptor tyrosine kinase inhibitors: 3-substituted quinoline derivatives. J Med Chem. 1994 Jul 8;37(14):2129-37. DMSGCKU RU https://pubmed.ncbi.nlm.nih.gov/8035419 DMSGCKU DI DMSGCKU DMSGCKU DN 3-(1H-Indol-3-yl)-6,7-dimethoxy-quinoline DMSGCKU MI TTI7421 DMSGCKU MN Platelet-derived growth factor receptor beta (PDGFRB) DMSGCKU MT DTT DMSGCKU MA Inhibitor DMSGCKU RN A new series of PDGF receptor tyrosine kinase inhibitors: 3-substituted quinoline derivatives. J Med Chem. 1994 Jul 8;37(14):2129-37. DMSGCKU RU https://pubmed.ncbi.nlm.nih.gov/8035419 DM6Y2XK DI DM6Y2XK DM6Y2XK DN 3-(1H-indol-3-yl)-N,N-dimethylpropan-1-amine DM6Y2XK MI TT3ROYC DM6Y2XK MN Serotonin transporter (SERT) DM6Y2XK MT DTT DM6Y2XK MA Inhibitor DM6Y2XK RN Conformationally restricted homotryptamines. Part 4: Heterocyclic and naphthyl analogs of a potent selective serotonin reuptake inhibitor. Bioorg Med Chem Lett. 2007 Oct 15;17(20):5647-51. DM6Y2XK RU https://pubmed.ncbi.nlm.nih.gov/17766113 DMEV6Q2 DI DMEV6Q2 DMEV6Q2 DN 3-(1H-indol-3-yl)-N-methyl-3-phenylpropan-1-amine DMEV6Q2 MI TTQ6VDM DMEV6Q2 MN Voltage-gated potassium channel Kv11.1 (KCNH2) DMEV6Q2 MT DTT DMEV6Q2 MA Inhibitor DMEV6Q2 RN Novel 3,3-disubstituted pyrrolidines as selective triple serotonin/norepinephrine/dopamine reuptake inhibitors. Bioorg Med Chem Lett. 2008 Dec 1;18(23):6062-6. DMEV6Q2 RU https://pubmed.ncbi.nlm.nih.gov/18954985 DMW7XN5 DI DMW7XN5 DMW7XN5 DN 3-(1H-Indol-3-yl)-quinoline DMW7XN5 MI TT8FYO9 DMW7XN5 MN Platelet-derived growth factor receptor alpha (PDGFRA) DMW7XN5 MT DTT DMW7XN5 MA Inhibitor DMW7XN5 RN A new series of PDGF receptor tyrosine kinase inhibitors: 3-substituted quinoline derivatives. J Med Chem. 1994 Jul 8;37(14):2129-37. DMW7XN5 RU https://pubmed.ncbi.nlm.nih.gov/8035419 DMW7XN5 DI DMW7XN5 DMW7XN5 DN 3-(1H-Indol-3-yl)-quinoline DMW7XN5 MI TTI7421 DMW7XN5 MN Platelet-derived growth factor receptor beta (PDGFRB) DMW7XN5 MT DTT DMW7XN5 MA Inhibitor DMW7XN5 RN A new series of PDGF receptor tyrosine kinase inhibitors: 3-substituted quinoline derivatives. J Med Chem. 1994 Jul 8;37(14):2129-37. DMW7XN5 RU https://pubmed.ncbi.nlm.nih.gov/8035419 DMKFGDI DI DMKFGDI DMKFGDI DN 3-(1H-pyrazol-3-yl)benzoic acid DMKFGDI MI TT6804T DMKFGDI MN MIF messenger RNA (MIF mRNA) DMKFGDI MT DTT DMKFGDI MA Inhibitor DMKFGDI RN Discovery of human macrophage migration inhibitory factor (MIF)-CD74 antagonists via virtual screening. J Med Chem. 2009 Jan 22;52(2):416-24. DMKFGDI RU https://pubmed.ncbi.nlm.nih.gov/19090668 DMCKJ27 DI DMCKJ27 DMCKJ27 DN 3-(1H-Pyrrol-3-yl)-propionamide DMCKJ27 MI TTG5QB7 DMCKJ27 MN Calpain-2 (CAPN2) DMCKJ27 MT DTT DMCKJ27 MA Inhibitor DMCKJ27 RN Synthesis of cystamidin a (pyrrole-3-propanamide), a reported calpain inhibitor, Bioorg. Med. Chem. Lett. 6(13):1541-1542 (1996). DMCKJ27 RU http://www.sciencedirect.com/science/article/pii/S0960894X96002697 DMU5HMC DI DMU5HMC DMU5HMC DN 3-(1-methyl-3,4-dihydronaphthalen-2-yl)-pyridine DMU5HMC MI TTSZLWK DMU5HMC MN Aromatase (CYP19A1) DMU5HMC MT DTT DMU5HMC MA Inhibitor DMU5HMC RN Synthesis and evaluation of heteroaryl-substituted dihydronaphthalenes and indenes: potent and selective inhibitors of aldosterone synthase (CYP11B... J Med Chem. 2006 Apr 6;49(7):2222-31. DMU5HMC RU https://pubmed.ncbi.nlm.nih.gov/16570918 DMU5HMC DI DMU5HMC DMU5HMC DN 3-(1-methyl-3,4-dihydronaphthalen-2-yl)-pyridine DMU5HMC MI TTIQUX7 DMU5HMC MN Steroid 11-beta-hydroxylase (CYP11B1) DMU5HMC MT DTT DMU5HMC MA Inhibitor DMU5HMC RN Synthesis and evaluation of heteroaryl-substituted dihydronaphthalenes and indenes: potent and selective inhibitors of aldosterone synthase (CYP11B... J Med Chem. 2006 Apr 6;49(7):2222-31. DMU5HMC RU https://pubmed.ncbi.nlm.nih.gov/16570918 DMU5HMC DI DMU5HMC DMU5HMC DN 3-(1-methyl-3,4-dihydronaphthalen-2-yl)-pyridine DMU5HMC MI TTRA5BZ DMU5HMC MN Steroid 17-alpha-monooxygenase (S17AH) DMU5HMC MT DTT DMU5HMC MA Inhibitor DMU5HMC RN Synthesis and evaluation of heteroaryl-substituted dihydronaphthalenes and indenes: potent and selective inhibitors of aldosterone synthase (CYP11B... J Med Chem. 2006 Apr 6;49(7):2222-31. DMU5HMC RU https://pubmed.ncbi.nlm.nih.gov/16570918 DMK8LHB DI DMK8LHB DMK8LHB DN 3-(1-Methyl-piperidin-2-yl)-2-phenyl-1H-indole DMK8LHB MI TTQ6VDM DMK8LHB MN Voltage-gated potassium channel Kv11.1 (KCNH2) DMK8LHB MT DTT DMK8LHB MA Inhibitor DMK8LHB RN 3-(4-Fluoropiperidin-3-yl)-2-phenylindoles as high affinity, selective, and orally bioavailable h5-HT(2A) receptor antagonists. J Med Chem. 2001 May 10;44(10):1603-14. DMK8LHB RU https://pubmed.ncbi.nlm.nih.gov/11334570 DM4UD8C DI DM4UD8C DM4UD8C DN 3-(1-Methyl-piperidin-3-yl)-2-phenyl-1H-indole DM4UD8C MI TTQ6VDM DM4UD8C MN Voltage-gated potassium channel Kv11.1 (KCNH2) DM4UD8C MT DTT DM4UD8C MA Inhibitor DM4UD8C RN 3-(4-Fluoropiperidin-3-yl)-2-phenylindoles as high affinity, selective, and orally bioavailable h5-HT(2A) receptor antagonists. J Med Chem. 2001 May 10;44(10):1603-14. DM4UD8C RU https://pubmed.ncbi.nlm.nih.gov/11334570 DM6R5HU DI DM6R5HU DM6R5HU DN 3-(1-Methyl-piperidin-4-yl)-2-phenyl-1H-indole DM6R5HU MI TTJQOD7 DM6R5HU MN 5-HT 2A receptor (HTR2A) DM6R5HU MT DTT DM6R5HU MA Inhibitor DM6R5HU RN 3-(4-Piperidinyl)- and 3-(8-aza-bicyclo[3.2.1]oct-3-yl)-2-phenyl-1H-indoles as bioavailable h5-HT2A antagonists. Bioorg Med Chem Lett. 2000 Dec 18;10(24):2701-3. DM6R5HU RU https://pubmed.ncbi.nlm.nih.gov/11133072 DMXMBEF DI DMXMBEF DMXMBEF DN 3-(1-NAPHTHYLMETHOXY)PYRIDIN-2-AMINE DMXMBEF MI TTQBR95 DMXMBEF MN Stress-activated protein kinase 2a (p38 alpha) DMXMBEF MT DTT DMXMBEF MA Inhibitor DMXMBEF RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DMXMBEF RU https://pubmed.ncbi.nlm.nih.gov/10592235 DMOQ4ER DI DMOQ4ER DMOQ4ER DN 3-(1-Phenethyl-piperidin-3-yl)-2-phenyl-1H-indole DMOQ4ER MI TTQ6VDM DMOQ4ER MN Voltage-gated potassium channel Kv11.1 (KCNH2) DMOQ4ER MT DTT DMOQ4ER MA Inhibitor DMOQ4ER RN 3-(4-Fluoropiperidin-3-yl)-2-phenylindoles as high affinity, selective, and orally bioavailable h5-HT(2A) receptor antagonists. J Med Chem. 2001 May 10;44(10):1603-14. DMOQ4ER RU https://pubmed.ncbi.nlm.nih.gov/11334570 DM8TH2N DI DM8TH2N DM8TH2N DN 3-(1-Phenethyl-piperidin-4-yl)-2-phenyl-1H-indole DM8TH2N MI TTJQOD7 DM8TH2N MN 5-HT 2A receptor (HTR2A) DM8TH2N MT DTT DM8TH2N MA Inhibitor DM8TH2N RN 3-(4-Piperidinyl)- and 3-(8-aza-bicyclo[3.2.1]oct-3-yl)-2-phenyl-1H-indoles as bioavailable h5-HT2A antagonists. Bioorg Med Chem Lett. 2000 Dec 18;10(24):2701-3. DM8TH2N RU https://pubmed.ncbi.nlm.nih.gov/11133072 DM8TH2N DI DM8TH2N DM8TH2N DN 3-(1-Phenethyl-piperidin-4-yl)-2-phenyl-1H-indole DM8TH2N MI TTQ6VDM DM8TH2N MN Voltage-gated potassium channel Kv11.1 (KCNH2) DM8TH2N MT DTT DM8TH2N MA Inhibitor DM8TH2N RN 3-(4-Fluoropiperidin-3-yl)-2-phenylindoles as high affinity, selective, and orally bioavailable h5-HT(2A) receptor antagonists. J Med Chem. 2001 May 10;44(10):1603-14. DM8TH2N RU https://pubmed.ncbi.nlm.nih.gov/11334570 DM4QRV9 DI DM4QRV9 DM4QRV9 DN 3-(1-Propyl-pyrrolidin-3-yl)-phenol DM4QRV9 MI TTSQIFT DM4QRV9 MN 5-HT 1A receptor (HTR1A) DM4QRV9 MT DTT DM4QRV9 MA Inhibitor DM4QRV9 RN Regioselective synthesis of 3-aryl substituted pyrrolidines via palladium catalyzed arylation: pharmacological evaluation for central dopaminergic and serotonergic activity, Bioorg. Med. Chem. Lett. 7(3):241-246 (1997). DM4QRV9 RU http://www.sciencedirect.com/science/article/pii/S0960894X9600618X DM4QRV9 DI DM4QRV9 DM4QRV9 DN 3-(1-Propyl-pyrrolidin-3-yl)-phenol DM4QRV9 MI TTEX248 DM4QRV9 MN Dopamine D2 receptor (D2R) DM4QRV9 MT DTT DM4QRV9 MA Inhibitor DM4QRV9 RN Regioselective synthesis of 3-aryl substituted pyrrolidines via palladium catalyzed arylation: pharmacological evaluation for central dopaminergic and serotonergic activity, Bioorg. Med. Chem. Lett. 7(3):241-246 (1997). DM4QRV9 RU http://www.sciencedirect.com/science/article/pii/S0960894X9600618X DM4QRV9 DI DM4QRV9 DM4QRV9 DN 3-(1-Propyl-pyrrolidin-3-yl)-phenol DM4QRV9 MI TT4C8EA DM4QRV9 MN Dopamine D3 receptor (D3R) DM4QRV9 MT DTT DM4QRV9 MA Inhibitor DM4QRV9 RN Regioselective synthesis of 3-aryl substituted pyrrolidines via palladium catalyzed arylation: pharmacological evaluation for central dopaminergic and serotonergic activity, Bioorg. Med. Chem. Lett. 7(3):241-246 (1997). DM4QRV9 RU http://www.sciencedirect.com/science/article/pii/S0960894X9600618X DMTD7VE DI DMTD7VE DMTD7VE DN 3-(1-Pyridin-2-yl-1H-pyrazol-3-yl)-benzonitrile DMTD7VE MI TTHS256 DMTD7VE MN Metabotropic glutamate receptor 5 (mGluR5) DMTD7VE MT DTT DMTD7VE MA Inhibitor DMTD7VE RN Discovery of novel heteroarylazoles that are metabotropic glutamate subtype 5 receptor antagonists with anxiolytic activity. J Med Chem. 2004 Sep 9;47(19):4645-8. Letter DMTD7VE RU https://pubmed.ncbi.nlm.nih.gov/15341479 DMWI37C DI DMWI37C DMWI37C DN 3-(1-Pyridin-2-yl-1H-pyrazol-4-yl)-benzonitrile DMWI37C MI TTHS256 DMWI37C MN Metabotropic glutamate receptor 5 (mGluR5) DMWI37C MT DTT DMWI37C MA Inhibitor DMWI37C RN Discovery of novel heteroarylazoles that are metabotropic glutamate subtype 5 receptor antagonists with anxiolytic activity. J Med Chem. 2004 Sep 9;47(19):4645-8. Letter DMWI37C RU https://pubmed.ncbi.nlm.nih.gov/15341479 DMJ9LRE DI DMJ9LRE DMJ9LRE DN 3-(1-Pyridin-2-yl-1H-pyrrol-3-yl)-benzonitrile DMJ9LRE MI TTHS256 DMJ9LRE MN Metabotropic glutamate receptor 5 (mGluR5) DMJ9LRE MT DTT DMJ9LRE MA Inhibitor DMJ9LRE RN Discovery of novel heteroarylazoles that are metabotropic glutamate subtype 5 receptor antagonists with anxiolytic activity. J Med Chem. 2004 Sep 9;47(19):4645-8. Letter DMJ9LRE RU https://pubmed.ncbi.nlm.nih.gov/15341479 DM8P26J DI DM8P26J DM8P26J DN 3-(2-((E)-3-phenylprop-1-enyl)phenyl)acrylic acid DM8P26J MI TT1ZAVI DM8P26J MN Prostaglandin E2 receptor EP2 (PTGER2) DM8P26J MT DTT DM8P26J MA Inhibitor DM8P26J RN Comparison between two classes of selective EP(3) antagonists and their biological activities. Bioorg Med Chem Lett. 2006 Nov 1;16(21):5639-42. DM8P26J RU https://pubmed.ncbi.nlm.nih.gov/16931013 DM8P26J DI DM8P26J DM8P26J DN 3-(2-((E)-3-phenylprop-1-enyl)phenyl)acrylic acid DM8P26J MI TTPNGDE DM8P26J MN Prostaglandin E2 receptor EP3 (PTGER3) DM8P26J MT DTT DM8P26J MA Inhibitor DM8P26J RN Comparison between two classes of selective EP(3) antagonists and their biological activities. Bioorg Med Chem Lett. 2006 Nov 1;16(21):5639-42. DM8P26J RU https://pubmed.ncbi.nlm.nih.gov/16931013 DM8P26J DI DM8P26J DM8P26J DN 3-(2-((E)-3-phenylprop-1-enyl)phenyl)acrylic acid DM8P26J MI TT79WV3 DM8P26J MN Prostaglandin E2 receptor EP4 (PTGER4) DM8P26J MT DTT DM8P26J MA Inhibitor DM8P26J RN Comparison between two classes of selective EP(3) antagonists and their biological activities. Bioorg Med Chem Lett. 2006 Nov 1;16(21):5639-42. DM8P26J RU https://pubmed.ncbi.nlm.nih.gov/16931013 DM61CHU DI DM61CHU DM61CHU DN 3-(2-(4-methoxycinnamyl)phenyl)acrylic acid DM61CHU MI TT1ZAVI DM61CHU MN Prostaglandin E2 receptor EP2 (PTGER2) DM61CHU MT DTT DM61CHU MA Inhibitor DM61CHU RN Comparison between two classes of selective EP(3) antagonists and their biological activities. Bioorg Med Chem Lett. 2006 Nov 1;16(21):5639-42. DM61CHU RU https://pubmed.ncbi.nlm.nih.gov/16931013 DM61CHU DI DM61CHU DM61CHU DN 3-(2-(4-methoxycinnamyl)phenyl)acrylic acid DM61CHU MI TTPNGDE DM61CHU MN Prostaglandin E2 receptor EP3 (PTGER3) DM61CHU MT DTT DM61CHU MA Inhibitor DM61CHU RN Comparison between two classes of selective EP(3) antagonists and their biological activities. Bioorg Med Chem Lett. 2006 Nov 1;16(21):5639-42. DM61CHU RU https://pubmed.ncbi.nlm.nih.gov/16931013 DM61CHU DI DM61CHU DM61CHU DN 3-(2-(4-methoxycinnamyl)phenyl)acrylic acid DM61CHU MI TT79WV3 DM61CHU MN Prostaglandin E2 receptor EP4 (PTGER4) DM61CHU MT DTT DM61CHU MA Inhibitor DM61CHU RN Comparison between two classes of selective EP(3) antagonists and their biological activities. Bioorg Med Chem Lett. 2006 Nov 1;16(21):5639-42. DM61CHU RU https://pubmed.ncbi.nlm.nih.gov/16931013 DM9O5CH DI DM9O5CH DM9O5CH DN 3-(2-(naphthalen-2-ylmethyl)phenyl)acrylic acid DM9O5CH MI TT1ZAVI DM9O5CH MN Prostaglandin E2 receptor EP2 (PTGER2) DM9O5CH MT DTT DM9O5CH MA Inhibitor DM9O5CH RN Comparison between two classes of selective EP(3) antagonists and their biological activities. Bioorg Med Chem Lett. 2006 Nov 1;16(21):5639-42. DM9O5CH RU https://pubmed.ncbi.nlm.nih.gov/16931013 DM9O5CH DI DM9O5CH DM9O5CH DN 3-(2-(naphthalen-2-ylmethyl)phenyl)acrylic acid DM9O5CH MI TTPNGDE DM9O5CH MN Prostaglandin E2 receptor EP3 (PTGER3) DM9O5CH MT DTT DM9O5CH MA Inhibitor DM9O5CH RN Comparison between two classes of selective EP(3) antagonists and their biological activities. Bioorg Med Chem Lett. 2006 Nov 1;16(21):5639-42. DM9O5CH RU https://pubmed.ncbi.nlm.nih.gov/16931013 DM9O5CH DI DM9O5CH DM9O5CH DN 3-(2-(naphthalen-2-ylmethyl)phenyl)acrylic acid DM9O5CH MI TT79WV3 DM9O5CH MN Prostaglandin E2 receptor EP4 (PTGER4) DM9O5CH MT DTT DM9O5CH MA Inhibitor DM9O5CH RN Comparison between two classes of selective EP(3) antagonists and their biological activities. Bioorg Med Chem Lett. 2006 Nov 1;16(21):5639-42. DM9O5CH RU https://pubmed.ncbi.nlm.nih.gov/16931013 DMSCIP2 DI DMSCIP2 DMSCIP2 DN 3-(2,2-Dimethyl-propoxy)-9H-beta-carboline DMSCIP2 MI TT1MPAY DMSCIP2 MN GABA(A) receptor alpha-1 (GABRA1) DMSCIP2 MT DTT DMSCIP2 MA Inhibitor DMSCIP2 RN Predictive binding of beta-carboline inverse agonists and antagonists via the CoMFA/GOLPE approach. J Med Chem. 1992 Oct 30;35(22):4001-10. DMSCIP2 RU https://pubmed.ncbi.nlm.nih.gov/1331452 DMSCIP2 DI DMSCIP2 DMSCIP2 DN 3-(2,2-Dimethyl-propoxy)-9H-beta-carboline DMSCIP2 MI TTNJYV2 DMSCIP2 MN Gamma-aminobutyric acid receptor (GAR) DMSCIP2 MT DTT DMSCIP2 MA Inhibitor DMSCIP2 RN Predictive binding of beta-carboline inverse agonists and antagonists via the CoMFA/GOLPE approach. J Med Chem. 1992 Oct 30;35(22):4001-10. DMSCIP2 RU https://pubmed.ncbi.nlm.nih.gov/1331452 DMCPOQ9 DI DMCPOQ9 DMCPOQ9 DN 3-(2,2-Diphenyl-vinyl)-pyridine DMCPOQ9 MI TTSZLWK DMCPOQ9 MN Aromatase (CYP19A1) DMCPOQ9 MT DTT DMCPOQ9 MA Inhibitor DMCPOQ9 RN Synthesis and evaluation of (pyridylmethylene)tetrahydronaphthalenes/-indanes and structurally modified derivatives: potent and selective inhibitor... J Med Chem. 2005 Mar 10;48(5):1563-75. DMCPOQ9 RU https://pubmed.ncbi.nlm.nih.gov/15743198 DMTS4YD DI DMTS4YD DMTS4YD DN 3-(2,3-Dihydro-1,4-benzodioxin-6-yl)pyridine DMTS4YD MI TTIQUX7 DMTS4YD MN Steroid 11-beta-hydroxylase (CYP11B1) DMTS4YD MT DTT DMTS4YD MA Inhibitor DMTS4YD RN In vivo active aldosterone synthase inhibitors with improved selectivity: lead optimization providing a series of pyridine substituted 3,4-dihydro-... J Med Chem. 2008 Dec 25;51(24):8077-87. DMTS4YD RU https://pubmed.ncbi.nlm.nih.gov/19049427 DM0ZRDV DI DM0ZRDV DM0ZRDV DN 3-(2,3-Dimethyl-phenyl)-1-propyl-piperidine DM0ZRDV MI TTEX248 DM0ZRDV MN Dopamine D2 receptor (D2R) DM0ZRDV MT DTT DM0ZRDV MA Inhibitor DM0ZRDV RN N-n-Propyl-substituted 3-(dimethylphenyl)piperidines display novel discriminative properties between dopamine receptor subtypes: synthesis and rece... J Med Chem. 1998 Dec 3;41(25):4933-8. DM0ZRDV RU https://pubmed.ncbi.nlm.nih.gov/9836610 DMEFKJD DI DMEFKJD DMEFKJD DN 3-(2,3-Dimethyl-phenyl)-piperidine DMEFKJD MI TTEX248 DMEFKJD MN Dopamine D2 receptor (D2R) DMEFKJD MT DTT DMEFKJD MA Inhibitor DMEFKJD RN N-n-Propyl-substituted 3-(dimethylphenyl)piperidines display novel discriminative properties between dopamine receptor subtypes: synthesis and rece... J Med Chem. 1998 Dec 3;41(25):4933-8. DMEFKJD RU https://pubmed.ncbi.nlm.nih.gov/9836610 DMXQROU DI DMXQROU DMXQROU DN 3-(2,4-dihydroxyphenyl)propionic acid DMXQROU MI TTULVH8 DMXQROU MN Tyrosinase (TYR) DMXQROU MT DTT DMXQROU MA Inhibitor DMXQROU RN Enhanced substituted resorcinol hydrophobicity augments tyrosinase inhibition potency. J Med Chem. 2007 May 31;50(11):2676-81. DMXQROU RU https://pubmed.ncbi.nlm.nih.gov/17447749 DMB71FZ DI DMB71FZ DMB71FZ DN 3-(2,4-Dimethyl-phenyl)-1-propyl-piperidine DMB71FZ MI TTEX248 DMB71FZ MN Dopamine D2 receptor (D2R) DMB71FZ MT DTT DMB71FZ MA Inhibitor DMB71FZ RN N-n-Propyl-substituted 3-(dimethylphenyl)piperidines display novel discriminative properties between dopamine receptor subtypes: synthesis and rece... J Med Chem. 1998 Dec 3;41(25):4933-8. DMB71FZ RU https://pubmed.ncbi.nlm.nih.gov/9836610 DMUDW1J DI DMUDW1J DMUDW1J DN 3-(2,5-dimethyl-1H-pyrrol-1-yl)benzoic acid DMUDW1J MI TTIQSC1 DMUDW1J MN Bacterial Lethal factor (Bact lef) DMUDW1J MT DTT DMUDW1J MA Inhibitor DMUDW1J RN Novel small-molecule inhibitors of anthrax lethal factor identified by high-throughput screening. J Med Chem. 2006 Aug 24;49(17):5232-44. DMUDW1J RU https://pubmed.ncbi.nlm.nih.gov/16913712 DM974E5 DI DM974E5 DM974E5 DN 3-(2,5-Dimethyl-phenyl)-1-propyl-piperidine DM974E5 MI TTEX248 DM974E5 MN Dopamine D2 receptor (D2R) DM974E5 MT DTT DM974E5 MA Inhibitor DM974E5 RN N-n-Propyl-substituted 3-(dimethylphenyl)piperidines display novel discriminative properties between dopamine receptor subtypes: synthesis and rece... J Med Chem. 1998 Dec 3;41(25):4933-8. DM974E5 RU https://pubmed.ncbi.nlm.nih.gov/9836610 DM6JTNW DI DM6JTNW DM6JTNW DN 3-(2,5-Dioxo-pyrrolidin-1-yl)-benzoic acid DM6JTNW MI TT1RS9F DM6JTNW MN Acetylcholinesterase (AChE) DM6JTNW MT DTT DM6JTNW MA Inhibitor DM6JTNW RN Synthesis, anticholinesterase activity and structure-activity relationships of m-Aminobenzoic acid derivatives. Bioorg Med Chem Lett. 2003 May 19;13(10):1825-7. DM6JTNW RU https://pubmed.ncbi.nlm.nih.gov/12729674 DMPSAQW DI DMPSAQW DMPSAQW DN 3-(2,6-Dimethyl-phenyl)-1-propyl-piperidine DMPSAQW MI TTEX248 DMPSAQW MN Dopamine D2 receptor (D2R) DMPSAQW MT DTT DMPSAQW MA Inhibitor DMPSAQW RN N-n-Propyl-substituted 3-(dimethylphenyl)piperidines display novel discriminative properties between dopamine receptor subtypes: synthesis and rece... J Med Chem. 1998 Dec 3;41(25):4933-8. DMPSAQW RU https://pubmed.ncbi.nlm.nih.gov/9836610 DMDYW4J DI DMDYW4J DMDYW4J DN 3-(2,6-diphenylpyridin-4-yl)phenol DMDYW4J MI TT0IHXV DMDYW4J MN DNA topoisomerase II (TOP2) DMDYW4J MT DTT DMDYW4J MA Inhibitor DMDYW4J RN Synthesis, topoisomerase I and II inhibitory activity, cytotoxicity, and structure-activity relationship study of hydroxylated 2,4-diphenyl-6-aryl ... Bioorg Med Chem. 2010 May 1;18(9):3066-77. DMDYW4J RU https://pubmed.ncbi.nlm.nih.gov/20392646 DMS98WA DI DMS98WA DMS98WA DN 3-(2-adamantyl) pyrrolidine DMS98WA MI TTXT3PU DMS98WA MN Influenza M2 protein (Influ M) DMS98WA MT DTT DMS98WA MA Inhibitor DMS98WA RN Antiviral agents active against influenza A viruses. Nat Rev Drug Discov. 2006 Dec;5(12):1015-25. DMS98WA RU https://pubmed.ncbi.nlm.nih.gov/17139286 DMQXPM3 DI DMQXPM3 DMQXPM3 DN 3-(2-Aminoethyl)-4-(Aminomethyl)Heptanedioic Acid DMQXPM3 MI TTJHKYD DMQXPM3 MN Delta-aminolevulinic acid dehydratase (ALAD) DMQXPM3 MT DTT DMQXPM3 MA Inhibitor DMQXPM3 RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMQXPM3 RU https://pubmed.ncbi.nlm.nih.gov/17139284 DM95R6O DI DM95R6O DM95R6O DN 3-(2-Amino-ethyl)-5-imino-[1,4]oxazepane DM95R6O MI TTZUFI5 DM95R6O MN Nitric-oxide synthase brain (NOS1) DM95R6O MT DTT DM95R6O MA Inhibitor DM95R6O RN Selective heterocyclic amidine inhibitors of human inducible nitric oxide synthase. Bioorg Med Chem Lett. 2001 Oct 8;11(19):2651-3. DM95R6O RU https://pubmed.ncbi.nlm.nih.gov/11551770 DM95R6O DI DM95R6O DM95R6O DN 3-(2-Amino-ethyl)-5-imino-[1,4]oxazepane DM95R6O MI TTF10I9 DM95R6O MN Nitric-oxide synthase inducible (NOS2) DM95R6O MT DTT DM95R6O MA Inhibitor DM95R6O RN Selective heterocyclic amidine inhibitors of human inducible nitric oxide synthase. Bioorg Med Chem Lett. 2001 Oct 8;11(19):2651-3. DM95R6O RU https://pubmed.ncbi.nlm.nih.gov/11551770 DMQPNUM DI DMQPNUM DMQPNUM DN 3-(2-Amino-propyl)-1H-indol-5-ol DMQPNUM MI TTSQIFT DMQPNUM MN 5-HT 1A receptor (HTR1A) DMQPNUM MT DTT DMQPNUM MA Inhibitor DMQPNUM RN A novel and selective 5-HT2 receptor agonist with ocular hypotensive activity: (S)-(+)-1-(2-aminopropyl)-8,9-dihydropyrano[3,2-e]indole. J Med Chem. 2003 Sep 11;46(19):4188-95. DMQPNUM RU https://pubmed.ncbi.nlm.nih.gov/12954071 DMQPNUM DI DMQPNUM DMQPNUM DN 3-(2-Amino-propyl)-1H-indol-5-ol DMQPNUM MI TTJQOD7 DMQPNUM MN 5-HT 2A receptor (HTR2A) DMQPNUM MT DTT DMQPNUM MA Inhibitor DMQPNUM RN 1-((S)-2-aminopropyl)-1H-indazol-6-ol: a potent peripherally acting 5-HT2 receptor agonist with ocular hypotensive activity. J Med Chem. 2006 Jan 12;49(1):318-28. DMQPNUM RU https://pubmed.ncbi.nlm.nih.gov/16392816 DMQPNUM DI DMQPNUM DMQPNUM DN 3-(2-Amino-propyl)-1H-indol-5-ol DMQPNUM MI TT0K1SC DMQPNUM MN 5-HT 2B receptor (HTR2B) DMQPNUM MT DTT DMQPNUM MA Inhibitor DMQPNUM RN 1-((S)-2-aminopropyl)-1H-indazol-6-ol: a potent peripherally acting 5-HT2 receptor agonist with ocular hypotensive activity. J Med Chem. 2006 Jan 12;49(1):318-28. DMQPNUM RU https://pubmed.ncbi.nlm.nih.gov/16392816 DMQPNUM DI DMQPNUM DMQPNUM DN 3-(2-Amino-propyl)-1H-indol-5-ol DMQPNUM MI TTWJBZ5 DMQPNUM MN 5-HT 2C receptor (HTR2C) DMQPNUM MT DTT DMQPNUM MA Inhibitor DMQPNUM RN 1-((S)-2-aminopropyl)-1H-indazol-6-ol: a potent peripherally acting 5-HT2 receptor agonist with ocular hypotensive activity. J Med Chem. 2006 Jan 12;49(1):318-28. DMQPNUM RU https://pubmed.ncbi.nlm.nih.gov/16392816 DMZCTGF DI DMZCTGF DMZCTGF DN 3-(2-Benzylamino-ethoxy)-phenol DMZCTGF MI TTSQIFT DMZCTGF MN 5-HT 1A receptor (HTR1A) DMZCTGF MT DTT DMZCTGF MA Inhibitor DMZCTGF RN New generation dopaminergic agents. 2. Discovery of 3-OH-phenoxyethylamine and 3-OH-N1-phenylpiperazine dopaminergic templates. Bioorg Med Chem Lett. 1998 Feb 3;8(3):295-300. DMZCTGF RU https://pubmed.ncbi.nlm.nih.gov/9871673 DMZCTGF DI DMZCTGF DMZCTGF DN 3-(2-Benzylamino-ethoxy)-phenol DMZCTGF MI TTEX248 DMZCTGF MN Dopamine D2 receptor (D2R) DMZCTGF MT DTT DMZCTGF MA Inhibitor DMZCTGF RN New generation dopaminergic agents. 7. Heterocyclic bioisosteres that exploit the 3-OH-phenoxyethylamine D2 template. Bioorg Med Chem Lett. 1999 Sep 6;9(17):2593-8. DMZCTGF RU https://pubmed.ncbi.nlm.nih.gov/10498215 DMZCTGF DI DMZCTGF DMZCTGF DN 3-(2-Benzylamino-ethoxy)-phenol DMZCTGF MI TT4C8EA DMZCTGF MN Dopamine D3 receptor (D3R) DMZCTGF MT DTT DMZCTGF MA Inhibitor DMZCTGF RN New generation dopaminergic agents. 7. Heterocyclic bioisosteres that exploit the 3-OH-phenoxyethylamine D2 template. Bioorg Med Chem Lett. 1999 Sep 6;9(17):2593-8. DMZCTGF RU https://pubmed.ncbi.nlm.nih.gov/10498215 DMZCTGF DI DMZCTGF DMZCTGF DN 3-(2-Benzylamino-ethoxy)-phenol DMZCTGF MI TTE0A2F DMZCTGF MN Dopamine D4 receptor (D4R) DMZCTGF MT DTT DMZCTGF MA Inhibitor DMZCTGF RN New generation dopaminergic agents. 7. Heterocyclic bioisosteres that exploit the 3-OH-phenoxyethylamine D2 template. Bioorg Med Chem Lett. 1999 Sep 6;9(17):2593-8. DMZCTGF RU https://pubmed.ncbi.nlm.nih.gov/10498215 DMH6I4E DI DMH6I4E DMH6I4E DN 3-(2-Bromophenyl)-2-thioxo-(1H )-quinazolin-4-one DMH6I4E MI TTVIAT9 DMH6I4E MN Phosphodiesterase 4B (PDE4B) DMH6I4E MT DTT DMH6I4E MA Inhibitor DMH6I4E RN CODES, a novel procedure for ligand-based virtual screening: PDE7 inhibitors as an application example. Eur J Med Chem. 2008 Jul;43(7):1349-59. DMH6I4E RU https://pubmed.ncbi.nlm.nih.gov/18082290 DMDM0R6 DI DMDM0R6 DMDM0R6 DN 3-(2-Bromophenyl)-6-methylcoumarin DMDM0R6 MI TTGP7BY DMDM0R6 MN Monoamine oxidase type B (MAO-B) DMDM0R6 MT DTT DMDM0R6 MA Inhibitor DMDM0R6 RN New halogenated 3-phenylcoumarins as potent and selective MAO-B inhibitors. Bioorg Med Chem Lett. 2010 Sep 1;20(17):5157-60. DMDM0R6 RU https://pubmed.ncbi.nlm.nih.gov/20659799 DMNOKR3 DI DMNOKR3 DMNOKR3 DN 3-(2-carbamoyl-5-mercaptopentyl)benzoic acid DMNOKR3 MI TT9G4N0 DMNOKR3 MN Glutamate carboxypeptidase II (GCPII) DMNOKR3 MT DTT DMNOKR3 MA Inhibitor DMNOKR3 RN Structural optimization of thiol-based inhibitors of glutamate carboxypeptidase II by modification of the P1' side chain. J Med Chem. 2006 May 18;49(10):2876-85. DMNOKR3 RU https://pubmed.ncbi.nlm.nih.gov/16686531 DM67B8S DI DM67B8S DM67B8S DN 3-(2-carboxy-3-mercaptopropyl)benzoic acid DM67B8S MI TT9G4N0 DM67B8S MN Glutamate carboxypeptidase II (GCPII) DM67B8S MT DTT DM67B8S MA Inhibitor DM67B8S RN Structural optimization of thiol-based inhibitors of glutamate carboxypeptidase II by modification of the P1' side chain. J Med Chem. 2006 May 18;49(10):2876-85. DM67B8S RU https://pubmed.ncbi.nlm.nih.gov/16686531 DMG5R0N DI DMG5R0N DMG5R0N DN 3-(2-carboxy-3-phosphonopropyl)benzoic acid DMG5R0N MI TT9G4N0 DMG5R0N MN Glutamate carboxypeptidase II (GCPII) DMG5R0N MT DTT DMG5R0N MA Inhibitor DMG5R0N RN Structural optimization of thiol-based inhibitors of glutamate carboxypeptidase II by modification of the P1' side chain. J Med Chem. 2006 May 18;49(10):2876-85. DMG5R0N RU https://pubmed.ncbi.nlm.nih.gov/16686531 DM6HPYN DI DM6HPYN DM6HPYN DN 3-(2-carboxy-4-mercaptobutyl)benzoic acid DM6HPYN MI TT9G4N0 DM6HPYN MN Glutamate carboxypeptidase II (GCPII) DM6HPYN MT DTT DM6HPYN MA Inhibitor DM6HPYN RN Structural optimization of thiol-based inhibitors of glutamate carboxypeptidase II by modification of the P1' side chain. J Med Chem. 2006 May 18;49(10):2876-85. DM6HPYN RU https://pubmed.ncbi.nlm.nih.gov/16686531 DM6H52B DI DM6H52B DM6H52B DN 3-(2-carboxy-5-mercaptopentyl)benzoic acid DM6H52B MI TT9G4N0 DM6H52B MN Glutamate carboxypeptidase II (GCPII) DM6H52B MT DTT DM6H52B MA Inhibitor DM6H52B RN Structural optimization of thiol-based inhibitors of glutamate carboxypeptidase II by modification of the P1' side chain. J Med Chem. 2006 May 18;49(10):2876-85. DM6H52B RU https://pubmed.ncbi.nlm.nih.gov/16686531 DM870W1 DI DM870W1 DM870W1 DN 3-(2-carboxy-6-mercaptohexyl)benzoic acid DM870W1 MI TT9G4N0 DM870W1 MN Glutamate carboxypeptidase II (GCPII) DM870W1 MT DTT DM870W1 MA Inhibitor DM870W1 RN Structural optimization of thiol-based inhibitors of glutamate carboxypeptidase II by modification of the P1' side chain. J Med Chem. 2006 May 18;49(10):2876-85. DM870W1 RU https://pubmed.ncbi.nlm.nih.gov/16686531 DMDS4Q0 DI DMDS4Q0 DMDS4Q0 DN 3-(2-Chloro-1,1-dimethyl-2-phenyl-ethyl)-pyridine DMDS4Q0 MI TTIQUX7 DMDS4Q0 MN Steroid 11-beta-hydroxylase (CYP11B1) DMDS4Q0 MT DTT DMDS4Q0 MA Inhibitor DMDS4Q0 RN Structure-activity relationship study of the inhibition of adrenal cortical 11 beta-hydroxylase by new metyrapone analogues. J Med Chem. 1984 Jan;27(1):15-9. DMDS4Q0 RU https://pubmed.ncbi.nlm.nih.gov/6606707 DM4XWME DI DM4XWME DM4XWME DN 3-(2-cinnamylphenyl)acrylic acid DM4XWME MI TT1ZAVI DM4XWME MN Prostaglandin E2 receptor EP2 (PTGER2) DM4XWME MT DTT DM4XWME MA Inhibitor DM4XWME RN Comparison between two classes of selective EP(3) antagonists and their biological activities. Bioorg Med Chem Lett. 2006 Nov 1;16(21):5639-42. DM4XWME RU https://pubmed.ncbi.nlm.nih.gov/16931013 DM4XWME DI DM4XWME DM4XWME DN 3-(2-cinnamylphenyl)acrylic acid DM4XWME MI TTPNGDE DM4XWME MN Prostaglandin E2 receptor EP3 (PTGER3) DM4XWME MT DTT DM4XWME MA Inhibitor DM4XWME RN Comparison between two classes of selective EP(3) antagonists and their biological activities. Bioorg Med Chem Lett. 2006 Nov 1;16(21):5639-42. DM4XWME RU https://pubmed.ncbi.nlm.nih.gov/16931013 DM4XWME DI DM4XWME DM4XWME DN 3-(2-cinnamylphenyl)acrylic acid DM4XWME MI TT79WV3 DM4XWME MN Prostaglandin E2 receptor EP4 (PTGER4) DM4XWME MT DTT DM4XWME MA Inhibitor DM4XWME RN Comparison between two classes of selective EP(3) antagonists and their biological activities. Bioorg Med Chem Lett. 2006 Nov 1;16(21):5639-42. DM4XWME RU https://pubmed.ncbi.nlm.nih.gov/16931013 DMVUK96 DI DMVUK96 DMVUK96 DN 3-(2-Cyclohexyl-ethyl)-6,7-dimethoxy-quinoline DMVUK96 MI TT8FYO9 DMVUK96 MN Platelet-derived growth factor receptor alpha (PDGFRA) DMVUK96 MT DTT DMVUK96 MA Inhibitor DMVUK96 RN A new series of PDGF receptor tyrosine kinase inhibitors: 3-substituted quinoline derivatives. J Med Chem. 1994 Jul 8;37(14):2129-37. DMVUK96 RU https://pubmed.ncbi.nlm.nih.gov/8035419 DMVUK96 DI DMVUK96 DMVUK96 DN 3-(2-Cyclohexyl-ethyl)-6,7-dimethoxy-quinoline DMVUK96 MI TTI7421 DMVUK96 MN Platelet-derived growth factor receptor beta (PDGFRB) DMVUK96 MT DTT DMVUK96 MA Inhibitor DMVUK96 RN A new series of PDGF receptor tyrosine kinase inhibitors: 3-substituted quinoline derivatives. J Med Chem. 1994 Jul 8;37(14):2129-37. DMVUK96 RU https://pubmed.ncbi.nlm.nih.gov/8035419 DM08GRF DI DM08GRF DM08GRF DN 3-(2-Diethylamino-acetamino)-rutaecarpine DM08GRF MI TT1RS9F DM08GRF MN Acetylcholinesterase (AChE) DM08GRF MT DTT DM08GRF MA Inhibitor DM08GRF RN Synthesis and evaluation of novel rutaecarpine derivatives and related alkaloids derivatives as selective acetylcholinesterase inhibitors. Eur J Med Chem. 2010 Apr;45(4):1415-23. DM08GRF RU https://pubmed.ncbi.nlm.nih.gov/20079560 DM08GRF DI DM08GRF DM08GRF DN 3-(2-Diethylamino-acetamino)-rutaecarpine DM08GRF MI TTEB0GD DM08GRF MN Cholinesterase (BCHE) DM08GRF MT DTT DM08GRF MA Inhibitor DM08GRF RN Synthesis and evaluation of novel rutaecarpine derivatives and related alkaloids derivatives as selective acetylcholinesterase inhibitors. Eur J Med Chem. 2010 Apr;45(4):1415-23. DM08GRF RU https://pubmed.ncbi.nlm.nih.gov/20079560 DM1FOIZ DI DM1FOIZ DM1FOIZ DN 3-(2-Diethylamino-propionamino)-rutaecarpine DM1FOIZ MI TT1RS9F DM1FOIZ MN Acetylcholinesterase (AChE) DM1FOIZ MT DTT DM1FOIZ MA Inhibitor DM1FOIZ RN Synthesis and evaluation of novel rutaecarpine derivatives and related alkaloids derivatives as selective acetylcholinesterase inhibitors. Eur J Med Chem. 2010 Apr;45(4):1415-23. DM1FOIZ RU https://pubmed.ncbi.nlm.nih.gov/20079560 DM1FOIZ DI DM1FOIZ DM1FOIZ DN 3-(2-Diethylamino-propionamino)-rutaecarpine DM1FOIZ MI TTEB0GD DM1FOIZ MN Cholinesterase (BCHE) DM1FOIZ MT DTT DM1FOIZ MA Inhibitor DM1FOIZ RN Synthesis and evaluation of novel rutaecarpine derivatives and related alkaloids derivatives as selective acetylcholinesterase inhibitors. Eur J Med Chem. 2010 Apr;45(4):1415-23. DM1FOIZ RU https://pubmed.ncbi.nlm.nih.gov/20079560 DM32MIE DI DM32MIE DM32MIE DN 3-(2-Dimethylamino-ethyl)-1H-indol-6-ol DM32MIE MI TTJQOD7 DM32MIE MN 5-HT 2A receptor (HTR2A) DM32MIE MT DTT DM32MIE MA Inhibitor DM32MIE RN SAR of psilocybin analogs: discovery of a selective 5-HT 2C agonist. Bioorg Med Chem Lett. 2005 Oct 15;15(20):4555-9. DM32MIE RU https://pubmed.ncbi.nlm.nih.gov/16061378 DM32MIE DI DM32MIE DM32MIE DN 3-(2-Dimethylamino-ethyl)-1H-indol-6-ol DM32MIE MI TT0K1SC DM32MIE MN 5-HT 2B receptor (HTR2B) DM32MIE MT DTT DM32MIE MA Inhibitor DM32MIE RN SAR of psilocybin analogs: discovery of a selective 5-HT 2C agonist. Bioorg Med Chem Lett. 2005 Oct 15;15(20):4555-9. DM32MIE RU https://pubmed.ncbi.nlm.nih.gov/16061378 DM32MIE DI DM32MIE DM32MIE DN 3-(2-Dimethylamino-ethyl)-1H-indol-6-ol DM32MIE MI TTWJBZ5 DM32MIE MN 5-HT 2C receptor (HTR2C) DM32MIE MT DTT DM32MIE MA Inhibitor DM32MIE RN SAR of psilocybin analogs: discovery of a selective 5-HT 2C agonist. Bioorg Med Chem Lett. 2005 Oct 15;15(20):4555-9. DM32MIE RU https://pubmed.ncbi.nlm.nih.gov/16061378 DMKYZGD DI DMKYZGD DMKYZGD DN 3-(2-Dimethylamino-ethyl)-1-methyl-1H-indol-4-ol DMKYZGD MI TTJQOD7 DMKYZGD MN 5-HT 2A receptor (HTR2A) DMKYZGD MT DTT DMKYZGD MA Inhibitor DMKYZGD RN SAR of psilocybin analogs: discovery of a selective 5-HT 2C agonist. Bioorg Med Chem Lett. 2005 Oct 15;15(20):4555-9. DMKYZGD RU https://pubmed.ncbi.nlm.nih.gov/16061378 DMKYZGD DI DMKYZGD DMKYZGD DN 3-(2-Dimethylamino-ethyl)-1-methyl-1H-indol-4-ol DMKYZGD MI TT0K1SC DMKYZGD MN 5-HT 2B receptor (HTR2B) DMKYZGD MT DTT DMKYZGD MA Inhibitor DMKYZGD RN SAR of psilocybin analogs: discovery of a selective 5-HT 2C agonist. Bioorg Med Chem Lett. 2005 Oct 15;15(20):4555-9. DMKYZGD RU https://pubmed.ncbi.nlm.nih.gov/16061378 DMKYZGD DI DMKYZGD DMKYZGD DN 3-(2-Dimethylamino-ethyl)-1-methyl-1H-indol-4-ol DMKYZGD MI TTWJBZ5 DMKYZGD MN 5-HT 2C receptor (HTR2C) DMKYZGD MT DTT DMKYZGD MA Inhibitor DMKYZGD RN SAR of psilocybin analogs: discovery of a selective 5-HT 2C agonist. Bioorg Med Chem Lett. 2005 Oct 15;15(20):4555-9. DMKYZGD RU https://pubmed.ncbi.nlm.nih.gov/16061378 DM9BTLC DI DM9BTLC DM9BTLC DN 3-(2-Dimethylamino-ethyl)-2-methyl-1H-indol-4-ol DM9BTLC MI TTJQOD7 DM9BTLC MN 5-HT 2A receptor (HTR2A) DM9BTLC MT DTT DM9BTLC MA Inhibitor DM9BTLC RN SAR of psilocybin analogs: discovery of a selective 5-HT 2C agonist. Bioorg Med Chem Lett. 2005 Oct 15;15(20):4555-9. DM9BTLC RU https://pubmed.ncbi.nlm.nih.gov/16061378 DM9BTLC DI DM9BTLC DM9BTLC DN 3-(2-Dimethylamino-ethyl)-2-methyl-1H-indol-4-ol DM9BTLC MI TTWJBZ5 DM9BTLC MN 5-HT 2C receptor (HTR2C) DM9BTLC MT DTT DM9BTLC MA Inhibitor DM9BTLC RN SAR of psilocybin analogs: discovery of a selective 5-HT 2C agonist. Bioorg Med Chem Lett. 2005 Oct 15;15(20):4555-9. DM9BTLC RU https://pubmed.ncbi.nlm.nih.gov/16061378 DMMJP9D DI DMMJP9D DMMJP9D DN 3-(2-Dimethylamino-propyl)-1H-indol-4-ol DMMJP9D MI TTJQOD7 DMMJP9D MN 5-HT 2A receptor (HTR2A) DMMJP9D MT DTT DMMJP9D MA Inhibitor DMMJP9D RN SAR of psilocybin analogs: discovery of a selective 5-HT 2C agonist. Bioorg Med Chem Lett. 2005 Oct 15;15(20):4555-9. DMMJP9D RU https://pubmed.ncbi.nlm.nih.gov/16061378 DMMJP9D DI DMMJP9D DMMJP9D DN 3-(2-Dimethylamino-propyl)-1H-indol-4-ol DMMJP9D MI TT0K1SC DMMJP9D MN 5-HT 2B receptor (HTR2B) DMMJP9D MT DTT DMMJP9D MA Inhibitor DMMJP9D RN SAR of psilocybin analogs: discovery of a selective 5-HT 2C agonist. Bioorg Med Chem Lett. 2005 Oct 15;15(20):4555-9. DMMJP9D RU https://pubmed.ncbi.nlm.nih.gov/16061378 DMMJP9D DI DMMJP9D DMMJP9D DN 3-(2-Dimethylamino-propyl)-1H-indol-4-ol DMMJP9D MI TTWJBZ5 DMMJP9D MN 5-HT 2C receptor (HTR2C) DMMJP9D MT DTT DMMJP9D MA Inhibitor DMMJP9D RN SAR of psilocybin analogs: discovery of a selective 5-HT 2C agonist. Bioorg Med Chem Lett. 2005 Oct 15;15(20):4555-9. DMMJP9D RU https://pubmed.ncbi.nlm.nih.gov/16061378 DMD24EW DI DMD24EW DMD24EW DN 3-(2-Hydroxy-phenyl)-benzo[d]isoxazol-6-ol DMD24EW MI TTZAYWL DMD24EW MN Estrogen receptor (ESR) DMD24EW MT DTT DMD24EW MA Inhibitor DMD24EW RN Design and synthesis of aryl diphenolic azoles as potent and selective estrogen receptor-beta ligands. J Med Chem. 2004 Oct 7;47(21):5021-40. DMD24EW RU https://pubmed.ncbi.nlm.nih.gov/15456246 DMD24EW DI DMD24EW DMD24EW DN 3-(2-Hydroxy-phenyl)-benzo[d]isoxazol-6-ol DMD24EW MI TTOM3J0 DMD24EW MN Estrogen receptor beta (ESR2) DMD24EW MT DTT DMD24EW MA Inhibitor DMD24EW RN Design and synthesis of aryl diphenolic azoles as potent and selective estrogen receptor-beta ligands. J Med Chem. 2004 Oct 7;47(21):5021-40. DMD24EW RU https://pubmed.ncbi.nlm.nih.gov/15456246 DM1DQGJ DI DM1DQGJ DM1DQGJ DN 3-(2-Methyl-2-aza-bicyclo[3.3.1]non-5-yl)-phenol DM1DQGJ MI TTKWM86 DM1DQGJ MN Opioid receptor mu (MOP) DM1DQGJ MT DTT DM1DQGJ MA Inhibitor DM1DQGJ RN Phenylmorphans and analogues: opioid receptor subtype selectivity and effect of conformation on activity. J Med Chem. 1992 May 1;35(9):1521-5. DM1DQGJ RU https://pubmed.ncbi.nlm.nih.gov/1315868 DMY782R DI DMY782R DMY782R DN 3-(2-methylbenzo[d]thiazol-5-yl)benzonitrile DMY782R MI TTHS256 DMY782R MN Metabotropic glutamate receptor 5 (mGluR5) DMY782R MT DTT DMY782R MA Inhibitor DMY782R RN Discovery of heterobicyclic templates for novel metabotropic glutamate receptor subtype 5 antagonists. Bioorg Med Chem Lett. 2007 Jun 1;17(11):2987-91. DMY782R RU https://pubmed.ncbi.nlm.nih.gov/17446071 DMUPB9H DI DMUPB9H DMUPB9H DN 3-(2-methylquinolin-7-yl)benzonitrile DMUPB9H MI TTHS256 DMUPB9H MN Metabotropic glutamate receptor 5 (mGluR5) DMUPB9H MT DTT DMUPB9H MA Inhibitor DMUPB9H RN Rational design of 7-arylquinolines as non-competitive metabotropic glutamate receptor subtype 5 antagonists. Bioorg Med Chem Lett. 2007 Aug 15;17(16):4415-8. DMUPB9H RU https://pubmed.ncbi.nlm.nih.gov/17590335 DM41HMZ DI DM41HMZ DM41HMZ DN 3-(2-methylquinolin-7-yl)phenol DM41HMZ MI TTHS256 DM41HMZ MN Metabotropic glutamate receptor 5 (mGluR5) DM41HMZ MT DTT DM41HMZ MA Inhibitor DM41HMZ RN Rational design of 7-arylquinolines as non-competitive metabotropic glutamate receptor subtype 5 antagonists. Bioorg Med Chem Lett. 2007 Aug 15;17(16):4415-8. DM41HMZ RU https://pubmed.ncbi.nlm.nih.gov/17590335 DM27HSO DI DM27HSO DM27HSO DN 3-(2-naphthyl)phenol DM27HSO MI TTIWB6L DM27HSO MN Estradiol 17 beta-dehydrogenase 1 (17-beta-HSD1) DM27HSO MT DTT DM27HSO MA Inhibitor DM27HSO RN Design, synthesis, and biological evaluation of (hydroxyphenyl)naphthalene and -quinoline derivatives: potent and selective nonsteroidal inhibitors... J Med Chem. 2008 Apr 10;51(7):2158-69. DM27HSO RU https://pubmed.ncbi.nlm.nih.gov/18324762 DMYXQ7L DI DMYXQ7L DMYXQ7L DN 3-(2-Nitro-ethyl)-[1,4]oxazepan-(5Z)-ylideneamine DMYXQ7L MI TTZUFI5 DMYXQ7L MN Nitric-oxide synthase brain (NOS1) DMYXQ7L MT DTT DMYXQ7L MA Inhibitor DMYXQ7L RN Selective heterocyclic amidine inhibitors of human inducible nitric oxide synthase. Bioorg Med Chem Lett. 2001 Oct 8;11(19):2651-3. DMYXQ7L RU https://pubmed.ncbi.nlm.nih.gov/11551770 DMYXQ7L DI DMYXQ7L DMYXQ7L DN 3-(2-Nitro-ethyl)-[1,4]oxazepan-(5Z)-ylideneamine DMYXQ7L MI TTF10I9 DMYXQ7L MN Nitric-oxide synthase inducible (NOS2) DMYXQ7L MT DTT DMYXQ7L MA Inhibitor DMYXQ7L RN Selective heterocyclic amidine inhibitors of human inducible nitric oxide synthase. Bioorg Med Chem Lett. 2001 Oct 8;11(19):2651-3. DMYXQ7L RU https://pubmed.ncbi.nlm.nih.gov/11551770 DM3BQO0 DI DM3BQO0 DM3BQO0 DN 3-(2-N-Piperidyl-acetamino)-rutaecarpine DM3BQO0 MI TT1RS9F DM3BQO0 MN Acetylcholinesterase (AChE) DM3BQO0 MT DTT DM3BQO0 MA Inhibitor DM3BQO0 RN Synthesis and evaluation of novel rutaecarpine derivatives and related alkaloids derivatives as selective acetylcholinesterase inhibitors. Eur J Med Chem. 2010 Apr;45(4):1415-23. DM3BQO0 RU https://pubmed.ncbi.nlm.nih.gov/20079560 DMFEHDY DI DMFEHDY DMFEHDY DN 3-(2-N-Piperidyl-propionamino)-rutaecarpine DMFEHDY MI TT1RS9F DMFEHDY MN Acetylcholinesterase (AChE) DMFEHDY MT DTT DMFEHDY MA Inhibitor DMFEHDY RN Synthesis and evaluation of novel rutaecarpine derivatives and related alkaloids derivatives as selective acetylcholinesterase inhibitors. Eur J Med Chem. 2010 Apr;45(4):1415-23. DMFEHDY RU https://pubmed.ncbi.nlm.nih.gov/20079560 DMFEHDY DI DMFEHDY DMFEHDY DN 3-(2-N-Piperidyl-propionamino)-rutaecarpine DMFEHDY MI TTEB0GD DMFEHDY MN Cholinesterase (BCHE) DMFEHDY MT DTT DMFEHDY MA Inhibitor DMFEHDY RN Synthesis and evaluation of novel rutaecarpine derivatives and related alkaloids derivatives as selective acetylcholinesterase inhibitors. Eur J Med Chem. 2010 Apr;45(4):1415-23. DMFEHDY RU https://pubmed.ncbi.nlm.nih.gov/20079560 DMQ0A8W DI DMQ0A8W DMQ0A8W DN 3-(2-N-Pyrrolyl-acetamino)-rutaecarpine DMQ0A8W MI TT1RS9F DMQ0A8W MN Acetylcholinesterase (AChE) DMQ0A8W MT DTT DMQ0A8W MA Inhibitor DMQ0A8W RN Synthesis and evaluation of novel rutaecarpine derivatives and related alkaloids derivatives as selective acetylcholinesterase inhibitors. Eur J Med Chem. 2010 Apr;45(4):1415-23. DMQ0A8W RU https://pubmed.ncbi.nlm.nih.gov/20079560 DMQ0A8W DI DMQ0A8W DMQ0A8W DN 3-(2-N-Pyrrolyl-acetamino)-rutaecarpine DMQ0A8W MI TTEB0GD DMQ0A8W MN Cholinesterase (BCHE) DMQ0A8W MT DTT DMQ0A8W MA Inhibitor DMQ0A8W RN Synthesis and evaluation of novel rutaecarpine derivatives and related alkaloids derivatives as selective acetylcholinesterase inhibitors. Eur J Med Chem. 2010 Apr;45(4):1415-23. DMQ0A8W RU https://pubmed.ncbi.nlm.nih.gov/20079560 DM9MRTW DI DM9MRTW DM9MRTW DN 3-(2-N-Pyrrolyl-propionamino)-rutaecarpine DM9MRTW MI TT1RS9F DM9MRTW MN Acetylcholinesterase (AChE) DM9MRTW MT DTT DM9MRTW MA Inhibitor DM9MRTW RN Synthesis and evaluation of novel rutaecarpine derivatives and related alkaloids derivatives as selective acetylcholinesterase inhibitors. Eur J Med Chem. 2010 Apr;45(4):1415-23. DM9MRTW RU https://pubmed.ncbi.nlm.nih.gov/20079560 DM9MRTW DI DM9MRTW DM9MRTW DN 3-(2-N-Pyrrolyl-propionamino)-rutaecarpine DM9MRTW MI TTEB0GD DM9MRTW MN Cholinesterase (BCHE) DM9MRTW MT DTT DM9MRTW MA Inhibitor DM9MRTW RN Synthesis and evaluation of novel rutaecarpine derivatives and related alkaloids derivatives as selective acetylcholinesterase inhibitors. Eur J Med Chem. 2010 Apr;45(4):1415-23. DM9MRTW RU https://pubmed.ncbi.nlm.nih.gov/20079560 DM0YEGM DI DM0YEGM DM0YEGM DN 3-(2-phenyl-2-(piperazin-1-yl)ethyl)benzamide DM0YEGM MI TT3ROYC DM0YEGM MN Serotonin transporter (SERT) DM0YEGM MT DTT DM0YEGM MA Inhibitor DM0YEGM RN N-(1,2-diphenylethyl)piperazines: a new class of dual serotonin/noradrenaline reuptake inhibitor. Bioorg Med Chem Lett. 2006 Aug 15;16(16):4345-8. DM0YEGM RU https://pubmed.ncbi.nlm.nih.gov/16750359 DM6YJOU DI DM6YJOU DM6YJOU DN 3-(2-phenyl-2-(piperazin-1-yl)ethyl)benzonitrile DM6YJOU MI TTAWNKZ DM6YJOU MN Norepinephrine transporter (NET) DM6YJOU MT DTT DM6YJOU MA Inhibitor DM6YJOU RN N-(1,2-diphenylethyl)piperazines: a new class of dual serotonin/noradrenaline reuptake inhibitor. Bioorg Med Chem Lett. 2006 Aug 15;16(16):4345-8. DM6YJOU RU https://pubmed.ncbi.nlm.nih.gov/16750359 DM6YJOU DI DM6YJOU DM6YJOU DN 3-(2-phenyl-2-(piperazin-1-yl)ethyl)benzonitrile DM6YJOU MI TT3ROYC DM6YJOU MN Serotonin transporter (SERT) DM6YJOU MT DTT DM6YJOU MA Inhibitor DM6YJOU RN N-(1,2-diphenylethyl)piperazines: a new class of dual serotonin/noradrenaline reuptake inhibitor. Bioorg Med Chem Lett. 2006 Aug 15;16(16):4345-8. DM6YJOU RU https://pubmed.ncbi.nlm.nih.gov/16750359 DM6QZTB DI DM6QZTB DM6QZTB DN 3-(2-phenyl-2-(piperazin-1-yl)ethyl)phenol DM6QZTB MI TTVBI8W DM6QZTB MN Dopamine transporter (DAT) DM6QZTB MT DTT DM6QZTB MA Inhibitor DM6QZTB RN N-(1,2-diphenylethyl)piperazines: a new class of dual serotonin/noradrenaline reuptake inhibitor. Bioorg Med Chem Lett. 2006 Aug 15;16(16):4345-8. DM6QZTB RU https://pubmed.ncbi.nlm.nih.gov/16750359 DM6QZTB DI DM6QZTB DM6QZTB DN 3-(2-phenyl-2-(piperazin-1-yl)ethyl)phenol DM6QZTB MI TTAWNKZ DM6QZTB MN Norepinephrine transporter (NET) DM6QZTB MT DTT DM6QZTB MA Inhibitor DM6QZTB RN N-(1,2-diphenylethyl)piperazines: a new class of dual serotonin/noradrenaline reuptake inhibitor. Bioorg Med Chem Lett. 2006 Aug 15;16(16):4345-8. DM6QZTB RU https://pubmed.ncbi.nlm.nih.gov/16750359 DM6QZTB DI DM6QZTB DM6QZTB DN 3-(2-phenyl-2-(piperazin-1-yl)ethyl)phenol DM6QZTB MI TT3ROYC DM6QZTB MN Serotonin transporter (SERT) DM6QZTB MT DTT DM6QZTB MA Inhibitor DM6QZTB RN N-(1,2-diphenylethyl)piperazines: a new class of dual serotonin/noradrenaline reuptake inhibitor. Bioorg Med Chem Lett. 2006 Aug 15;16(16):4345-8. DM6QZTB RU https://pubmed.ncbi.nlm.nih.gov/16750359 DM63T9D DI DM63T9D DM63T9D DN 3-(2-phenyl-6-(thiophen-2-yl)pyridin-4-yl)-phenol DM63T9D MI TT0IHXV DM63T9D MN DNA topoisomerase II (TOP2) DM63T9D MT DTT DM63T9D MA Inhibitor DM63T9D RN Synthesis, topoisomerase I and II inhibitory activity, cytotoxicity, and structure-activity relationship study of hydroxylated 2,4-diphenyl-6-aryl ... Bioorg Med Chem. 2010 May 1;18(9):3066-77. DM63T9D RU https://pubmed.ncbi.nlm.nih.gov/20392646 DMF369N DI DMF369N DMF369N DN 3-(2-phenyl-6-(thiophen-3-yl)pyridin-4-yl)-phenol DMF369N MI TT0IHXV DMF369N MN DNA topoisomerase II (TOP2) DMF369N MT DTT DMF369N MA Inhibitor DMF369N RN Synthesis, topoisomerase I and II inhibitory activity, cytotoxicity, and structure-activity relationship study of hydroxylated 2,4-diphenyl-6-aryl ... Bioorg Med Chem. 2010 May 1;18(9):3066-77. DMF369N RU https://pubmed.ncbi.nlm.nih.gov/20392646 DMQC9WV DI DMQC9WV DMQC9WV DN 3-(2-phenylthiazol-4-yl)quinolin-2(1H)-one DMQC9WV MI TTL4Q97 DMQC9WV MN Cyclin-dependent kinase 5 (CDK5) DMQC9WV MT DTT DMQC9WV MA Inhibitor DMQC9WV RN Design and synthesis of quinolin-2(1H)-one derivatives as potent CDK5 inhibitors. Bioorg Med Chem Lett. 2007 Oct 1;17(19):5384-9. DMQC9WV RU https://pubmed.ncbi.nlm.nih.gov/17709247 DM2IYAP DI DM2IYAP DM2IYAP DN 3-(2-propyn-1-yl)thymidine DM2IYAP MI TTP3QRF DM2IYAP MN Thymidine kinase 1 (TK1) DM2IYAP MT DTT DM2IYAP MA Inhibitor DM2IYAP RN Synthesis, in vitro, and in silico evaluation of organometallic technetium and rhenium thymidine complexes with retained substrate activity toward ... J Med Chem. 2008 Nov 13;51(21):6689-98. DM2IYAP RU https://pubmed.ncbi.nlm.nih.gov/18837546 DMPWEL8 DI DMPWEL8 DMPWEL8 DN 3-(2-Pyridin-2-yl-2H-tetrazol-5-yl)-benzonitrile DMPWEL8 MI TTHS256 DMPWEL8 MN Metabotropic glutamate receptor 5 (mGluR5) DMPWEL8 MT DTT DMPWEL8 MA Inhibitor DMPWEL8 RN Discovery of novel heteroarylazoles that are metabotropic glutamate subtype 5 receptor antagonists with anxiolytic activity. J Med Chem. 2004 Sep 9;47(19):4645-8. Letter DMPWEL8 RU https://pubmed.ncbi.nlm.nih.gov/15341479 DM7VJPX DI DM7VJPX DM7VJPX DN 3-(2-Pyrrolidin-1-yl-ethyl)-1H-indol-4-ol DM7VJPX MI TTJQOD7 DM7VJPX MN 5-HT 2A receptor (HTR2A) DM7VJPX MT DTT DM7VJPX MA Inhibitor DM7VJPX RN SAR of psilocybin analogs: discovery of a selective 5-HT 2C agonist. Bioorg Med Chem Lett. 2005 Oct 15;15(20):4555-9. DM7VJPX RU https://pubmed.ncbi.nlm.nih.gov/16061378 DM7VJPX DI DM7VJPX DM7VJPX DN 3-(2-Pyrrolidin-1-yl-ethyl)-1H-indol-4-ol DM7VJPX MI TT0K1SC DM7VJPX MN 5-HT 2B receptor (HTR2B) DM7VJPX MT DTT DM7VJPX MA Inhibitor DM7VJPX RN SAR of psilocybin analogs: discovery of a selective 5-HT 2C agonist. Bioorg Med Chem Lett. 2005 Oct 15;15(20):4555-9. DM7VJPX RU https://pubmed.ncbi.nlm.nih.gov/16061378 DM7VJPX DI DM7VJPX DM7VJPX DN 3-(2-Pyrrolidin-1-yl-ethyl)-1H-indol-4-ol DM7VJPX MI TTWJBZ5 DM7VJPX MN 5-HT 2C receptor (HTR2C) DM7VJPX MT DTT DM7VJPX MA Inhibitor DM7VJPX RN SAR of psilocybin analogs: discovery of a selective 5-HT 2C agonist. Bioorg Med Chem Lett. 2005 Oct 15;15(20):4555-9. DM7VJPX RU https://pubmed.ncbi.nlm.nih.gov/16061378 DMKAEUD DI DMKAEUD DMKAEUD DN 3-(3-(3-chlorobenzyloxy)-5-methylphenyl)pyridine DMKAEUD MI TTHS256 DMKAEUD MN Metabotropic glutamate receptor 5 (mGluR5) DMKAEUD MT DTT DMKAEUD MA Inhibitor DMKAEUD RN Arylmethoxypyridines as novel, potent and orally active mGlu5 receptor antagonists. Bioorg Med Chem Lett. 2006 Apr 1;16(7):1892-7. DMKAEUD RU https://pubmed.ncbi.nlm.nih.gov/16439120 DMY4VX2 DI DMY4VX2 DMY4VX2 DN 3-(3-(benzamido)-5-nitrobenzamido)propanoic acid DMY4VX2 MI TTSJ542 DMY4VX2 MN Integrin alpha-2 (ITGA2) DMY4VX2 MT DTT DMY4VX2 MA Inhibitor DMY4VX2 RN Derivatives of 7-amino-1,2,3,4-tetrahydroisoquinoline and isophthalic acids as novel fibrinogen receptor antagonists. Bioorg Med Chem Lett. 2006 Oct 15;16(20):5294-7. DMY4VX2 RU https://pubmed.ncbi.nlm.nih.gov/16919941 DMY4VX2 DI DMY4VX2 DMY4VX2 DN 3-(3-(benzamido)-5-nitrobenzamido)propanoic acid DMY4VX2 MI TTJA1ZO DMY4VX2 MN ITGB3 messenger RNA (ITGB3 mRNA) DMY4VX2 MT DTT DMY4VX2 MA Inhibitor DMY4VX2 RN Derivatives of 7-amino-1,2,3,4-tetrahydroisoquinoline and isophthalic acids as novel fibrinogen receptor antagonists. Bioorg Med Chem Lett. 2006 Oct 15;16(20):5294-7. DMY4VX2 RU https://pubmed.ncbi.nlm.nih.gov/16919941 DM2K51S DI DM2K51S DM2K51S DN 3-(3-(carbamoyl)benzamido)-3-phenylpropanoic acid DM2K51S MI TTSJ542 DM2K51S MN Integrin alpha-2 (ITGA2) DM2K51S MT DTT DM2K51S MA Inhibitor DM2K51S RN Derivatives of 7-amino-1,2,3,4-tetrahydroisoquinoline and isophthalic acids as novel fibrinogen receptor antagonists. Bioorg Med Chem Lett. 2006 Oct 15;16(20):5294-7. DM2K51S RU https://pubmed.ncbi.nlm.nih.gov/16919941 DM2K51S DI DM2K51S DM2K51S DN 3-(3-(carbamoyl)benzamido)-3-phenylpropanoic acid DM2K51S MI TTJA1ZO DM2K51S MN ITGB3 messenger RNA (ITGB3 mRNA) DM2K51S MT DTT DM2K51S MA Inhibitor DM2K51S RN Derivatives of 7-amino-1,2,3,4-tetrahydroisoquinoline and isophthalic acids as novel fibrinogen receptor antagonists. Bioorg Med Chem Lett. 2006 Oct 15;16(20):5294-7. DM2K51S RU https://pubmed.ncbi.nlm.nih.gov/16919941 DM31JAZ DI DM31JAZ DM31JAZ DN 3-(3-(carbamoyl)benzamido)propanoic acid DM31JAZ MI TTSJ542 DM31JAZ MN Integrin alpha-2 (ITGA2) DM31JAZ MT DTT DM31JAZ MA Inhibitor DM31JAZ RN Derivatives of 7-amino-1,2,3,4-tetrahydroisoquinoline and isophthalic acids as novel fibrinogen receptor antagonists. Bioorg Med Chem Lett. 2006 Oct 15;16(20):5294-7. DM31JAZ RU https://pubmed.ncbi.nlm.nih.gov/16919941 DM31JAZ DI DM31JAZ DM31JAZ DN 3-(3-(carbamoyl)benzamido)propanoic acid DM31JAZ MI TTJA1ZO DM31JAZ MN ITGB3 messenger RNA (ITGB3 mRNA) DM31JAZ MT DTT DM31JAZ MA Inhibitor DM31JAZ RN Derivatives of 7-amino-1,2,3,4-tetrahydroisoquinoline and isophthalic acids as novel fibrinogen receptor antagonists. Bioorg Med Chem Lett. 2006 Oct 15;16(20):5294-7. DM31JAZ RU https://pubmed.ncbi.nlm.nih.gov/16919941 DMSHORK DI DMSHORK DMSHORK DN 3-(3,3-dimethyl-2-oxoindolin-5-yl)benzonitrile DMSHORK MI TTUV8G9 DMSHORK MN Progesterone receptor (PGR) DMSHORK MT DTT DMSHORK MA Inhibitor DMSHORK RN Design, synthesis, and SAR of new pyrrole-oxindole progesterone receptor modulators leading to 5-(7-fluoro-3,3-dimethyl-2-oxo-2,3-dihydro-1H-indol-... J Med Chem. 2008 Mar 27;51(6):1861-73. DMSHORK RU https://pubmed.ncbi.nlm.nih.gov/18318463 DMT3AW8 DI DMT3AW8 DMT3AW8 DN 3-(3,4-dichlorophenyl)-2-nortropene DMT3AW8 MI TTVBI8W DMT3AW8 MN Dopamine transporter (DAT) DMT3AW8 MT DTT DMT3AW8 MA Inhibitor DMT3AW8 RN Synthesis and monoamine transporter affinity of 3alpha-arylmethoxy-3beta-arylnortropanes. Bioorg Med Chem Lett. 2009 Dec 15;19(24):6865-8. DMT3AW8 RU https://pubmed.ncbi.nlm.nih.gov/19896846 DMT3AW8 DI DMT3AW8 DMT3AW8 DN 3-(3,4-dichlorophenyl)-2-nortropene DMT3AW8 MI TT3ROYC DMT3AW8 MN Serotonin transporter (SERT) DMT3AW8 MT DTT DMT3AW8 MA Inhibitor DMT3AW8 RN Synthesis and monoamine transporter affinity of 3alpha-arylmethoxy-3beta-arylnortropanes. Bioorg Med Chem Lett. 2009 Dec 15;19(24):6865-8. DMT3AW8 RU https://pubmed.ncbi.nlm.nih.gov/19896846 DMEJH13 DI DMEJH13 DMEJH13 DN 3-(3,4-Dichloro-phenyl)-6,7-dimethoxy-quinoline DMEJH13 MI TT8FYO9 DMEJH13 MN Platelet-derived growth factor receptor alpha (PDGFRA) DMEJH13 MT DTT DMEJH13 MA Inhibitor DMEJH13 RN A new series of PDGF receptor tyrosine kinase inhibitors: 3-substituted quinoline derivatives. J Med Chem. 1994 Jul 8;37(14):2129-37. DMEJH13 RU https://pubmed.ncbi.nlm.nih.gov/8035419 DMEJH13 DI DMEJH13 DMEJH13 DN 3-(3,4-Dichloro-phenyl)-6,7-dimethoxy-quinoline DMEJH13 MI TTI7421 DMEJH13 MN Platelet-derived growth factor receptor beta (PDGFRB) DMEJH13 MT DTT DMEJH13 MA Inhibitor DMEJH13 RN A new series of PDGF receptor tyrosine kinase inhibitors: 3-substituted quinoline derivatives. J Med Chem. 1994 Jul 8;37(14):2129-37. DMEJH13 RU https://pubmed.ncbi.nlm.nih.gov/8035419 DMX3AMB DI DMX3AMB DMX3AMB DN 3-(3,4-Difluoro-phenyl)-6,7-dimethoxy-quinoline DMX3AMB MI TT8FYO9 DMX3AMB MN Platelet-derived growth factor receptor alpha (PDGFRA) DMX3AMB MT DTT DMX3AMB MA Inhibitor DMX3AMB RN A new series of PDGF receptor tyrosine kinase inhibitors: 3-substituted quinoline derivatives. J Med Chem. 1994 Jul 8;37(14):2129-37. DMX3AMB RU https://pubmed.ncbi.nlm.nih.gov/8035419 DMX3AMB DI DMX3AMB DMX3AMB DN 3-(3,4-Difluoro-phenyl)-6,7-dimethoxy-quinoline DMX3AMB MI TTI7421 DMX3AMB MN Platelet-derived growth factor receptor beta (PDGFRB) DMX3AMB MT DTT DMX3AMB MA Inhibitor DMX3AMB RN A new series of PDGF receptor tyrosine kinase inhibitors: 3-substituted quinoline derivatives. J Med Chem. 1994 Jul 8;37(14):2129-37. DMX3AMB RU https://pubmed.ncbi.nlm.nih.gov/8035419 DM0VL17 DI DM0VL17 DM0VL17 DN 3-(3,4-dihydronaphthalen-2-yl)pyridine DM0VL17 MI TTSZLWK DM0VL17 MN Aromatase (CYP19A1) DM0VL17 MT DTT DM0VL17 MA Inhibitor DM0VL17 RN Synthesis and evaluation of heteroaryl-substituted dihydronaphthalenes and indenes: potent and selective inhibitors of aldosterone synthase (CYP11B... J Med Chem. 2006 Apr 6;49(7):2222-31. DM0VL17 RU https://pubmed.ncbi.nlm.nih.gov/16570918 DM0VL17 DI DM0VL17 DM0VL17 DN 3-(3,4-dihydronaphthalen-2-yl)pyridine DM0VL17 MI TTIQUX7 DM0VL17 MN Steroid 11-beta-hydroxylase (CYP11B1) DM0VL17 MT DTT DM0VL17 MA Inhibitor DM0VL17 RN Synthesis and evaluation of heteroaryl-substituted dihydronaphthalenes and indenes: potent and selective inhibitors of aldosterone synthase (CYP11B... J Med Chem. 2006 Apr 6;49(7):2222-31. DM0VL17 RU https://pubmed.ncbi.nlm.nih.gov/16570918 DMDU10A DI DMDU10A DMDU10A DN 3-(3,4-Dimethoxy-phenyl)-6,7-dimethoxy-quinoline DMDU10A MI TT8FYO9 DMDU10A MN Platelet-derived growth factor receptor alpha (PDGFRA) DMDU10A MT DTT DMDU10A MA Inhibitor DMDU10A RN A new series of PDGF receptor tyrosine kinase inhibitors: 3-substituted quinoline derivatives. J Med Chem. 1994 Jul 8;37(14):2129-37. DMDU10A RU https://pubmed.ncbi.nlm.nih.gov/8035419 DMDU10A DI DMDU10A DMDU10A DN 3-(3,4-Dimethoxy-phenyl)-6,7-dimethoxy-quinoline DMDU10A MI TTI7421 DMDU10A MN Platelet-derived growth factor receptor beta (PDGFRB) DMDU10A MT DTT DMDU10A MA Inhibitor DMDU10A RN A new series of PDGF receptor tyrosine kinase inhibitors: 3-substituted quinoline derivatives. J Med Chem. 1994 Jul 8;37(14):2129-37. DMDU10A RU https://pubmed.ncbi.nlm.nih.gov/8035419 DM9BYVL DI DM9BYVL DM9BYVL DN 3-(3,4-Dimethylbenzyl)-4-hydroxy-2H-chromen-2-one DM9BYVL MI TT8XK6L DM9BYVL MN Quinone reductase 1 (NQO1) DM9BYVL MT DTT DM9BYVL MA Inhibitor DM9BYVL RN Synthesis and biological evaluation of coumarin-based inhibitors of NAD(P)H: quinone oxidoreductase-1 (NQO1). J Med Chem. 2009 Nov 26;52(22):7142-56. DM9BYVL RU https://pubmed.ncbi.nlm.nih.gov/19877692 DMULX9O DI DMULX9O DMULX9O DN 3-(3,4-dimethylphenyl)-1,5-naphthyridine DMULX9O MI TTHS256 DMULX9O MN Metabotropic glutamate receptor 5 (mGluR5) DMULX9O MT DTT DMULX9O MA Inhibitor DMULX9O RN Synthesis and SAR comparison of regioisomeric aryl naphthyridines as potent mGlu5 receptor antagonists. Bioorg Med Chem Lett. 2007 Dec 1;17(23):6525-8. DMULX9O RU https://pubmed.ncbi.nlm.nih.gov/17936624 DM8W9EO DI DM8W9EO DM8W9EO DN 3-(3,4-Dimethyl-phenyl)-1-propyl-piperidine DM8W9EO MI TTEX248 DM8W9EO MN Dopamine D2 receptor (D2R) DM8W9EO MT DTT DM8W9EO MA Inhibitor DM8W9EO RN N-n-Propyl-substituted 3-(dimethylphenyl)piperidines display novel discriminative properties between dopamine receptor subtypes: synthesis and rece... J Med Chem. 1998 Dec 3;41(25):4933-8. DM8W9EO RU https://pubmed.ncbi.nlm.nih.gov/9836610 DMOW0L9 DI DMOW0L9 DMOW0L9 DN 3-(3,4-Dimethyl-phenyl)-piperidine DMOW0L9 MI TTEX248 DMOW0L9 MN Dopamine D2 receptor (D2R) DMOW0L9 MT DTT DMOW0L9 MA Inhibitor DMOW0L9 RN N-n-Propyl-substituted 3-(dimethylphenyl)piperidines display novel discriminative properties between dopamine receptor subtypes: synthesis and rece... J Med Chem. 1998 Dec 3;41(25):4933-8. DMOW0L9 RU https://pubmed.ncbi.nlm.nih.gov/9836610 DMDFHCU DI DMDFHCU DMDFHCU DN 3-(3,5-Dibromo-4-hexyloxy-phenyl)-propionic acid DMDFHCU MI TTTSEPU DMDFHCU MN Thyroid hormone receptor alpha (THRA) DMDFHCU MT DTT DMDFHCU MA Inhibitor DMDFHCU RN Thyroid receptor ligands. 3. Design and synthesis of 3,5-dihalo-4-alkoxyphenylalkanoic acids as indirect antagonists of the thyroid hormone receptor. J Med Chem. 2005 May 5;48(9):3114-7. DMDFHCU RU https://pubmed.ncbi.nlm.nih.gov/15857115 DMDFHCU DI DMDFHCU DMDFHCU DN 3-(3,5-Dibromo-4-hexyloxy-phenyl)-propionic acid DMDFHCU MI TTGER3L DMDFHCU MN Thyroid hormone receptor beta (THRB) DMDFHCU MT DTT DMDFHCU MA Inhibitor DMDFHCU RN Thyroid receptor ligands. 3. Design and synthesis of 3,5-dihalo-4-alkoxyphenylalkanoic acids as indirect antagonists of the thyroid hormone receptor. J Med Chem. 2005 May 5;48(9):3114-7. DMDFHCU RU https://pubmed.ncbi.nlm.nih.gov/15857115 DMSI3V4 DI DMSI3V4 DMSI3V4 DN 3-(3,5-Dimethyl-phenyl)-1-propyl-piperidine DMSI3V4 MI TTEX248 DMSI3V4 MN Dopamine D2 receptor (D2R) DMSI3V4 MT DTT DMSI3V4 MA Inhibitor DMSI3V4 RN N-n-Propyl-substituted 3-(dimethylphenyl)piperidines display novel discriminative properties between dopamine receptor subtypes: synthesis and rece... J Med Chem. 1998 Dec 3;41(25):4933-8. DMSI3V4 RU https://pubmed.ncbi.nlm.nih.gov/9836610 DMUWKMN DI DMUWKMN DMUWKMN DN 3-(3,5-Dimethyl-phenyl)-piperidine DMUWKMN MI TTEX248 DMUWKMN MN Dopamine D2 receptor (D2R) DMUWKMN MT DTT DMUWKMN MA Inhibitor DMUWKMN RN N-n-Propyl-substituted 3-(dimethylphenyl)piperidines display novel discriminative properties between dopamine receptor subtypes: synthesis and rece... J Med Chem. 1998 Dec 3;41(25):4933-8. DMUWKMN RU https://pubmed.ncbi.nlm.nih.gov/9836610 DMT0M94 DI DMT0M94 DMT0M94 DN 3-(3-Adamantan-1-yl-ureido)-benzoic acid DMT0M94 MI TT7WVHI DMT0M94 MN Soluble epoxide hydrolase (EPHX2) DMT0M94 MT DTT DMT0M94 MA Inhibitor DMT0M94 RN Salicylate-urea-based soluble epoxide hydrolase inhibitors with high metabolic and chemical stabilities. Bioorg Med Chem Lett. 2009 Mar 15;19(6):1784-9. DMT0M94 RU https://pubmed.ncbi.nlm.nih.gov/19216074 DMLYVPH DI DMLYVPH DMLYVPH DN 3-(3-aminobenzo[e][1,2,4]triazin-7-yl)phenol DMLYVPH MI TT6PKBN DMLYVPH MN Proto-oncogene c-Src (SRC) DMLYVPH MT DTT DMLYVPH MA Inhibitor DMLYVPH RN Discovery and preliminary structure-activity relationship studies of novel benzotriazine based compounds as Src inhibitors. Bioorg Med Chem Lett. 2006 Nov 1;16(21):5546-50. DMLYVPH RU https://pubmed.ncbi.nlm.nih.gov/16931012 DMB6SP8 DI DMB6SP8 DMB6SP8 DN 3-(3-aminocyclopentyl)-1H-indole-5-carbonitrile DMB6SP8 MI TT3ROYC DMB6SP8 MN Serotonin transporter (SERT) DMB6SP8 MT DTT DMB6SP8 MA Inhibitor DMB6SP8 RN Conformationally restricted homotryptamines. Part 7: 3-cis-(3-aminocyclopentyl)indoles as potent selective serotonin reuptake inhibitors. J Med Chem. 2010 Nov 11;53(21):7564-72. DMB6SP8 RU https://pubmed.ncbi.nlm.nih.gov/20949929 DMXKL75 DI DMXKL75 DMXKL75 DN 3-(3-Benzoyl-1H-pyrrol-1-yl)propanoic acid DMXKL75 MI TTFBNVI DMXKL75 MN Aldose reductase (AKR1B1) DMXKL75 MT DTT DMXKL75 MA Inhibitor DMXKL75 RN Design and synthesis of novel series of pyrrole based chemotypes and their evaluation as selective aldose reductase inhibitors. A case of bioisoste... Bioorg Med Chem. 2010 Mar 15;18(6):2107-2114. DMXKL75 RU https://pubmed.ncbi.nlm.nih.gov/20189816 DM1325C DI DM1325C DM1325C DN 3-(3-Benzyl-6-methoxynaphthalen-2-yl)pyridine DM1325C MI TTIQUX7 DM1325C MN Steroid 11-beta-hydroxylase (CYP11B1) DM1325C MT DTT DM1325C MA Inhibitor DM1325C RN Novel aldosterone synthase inhibitors with extended carbocyclic skeleton by a combined ligand-based and structure-based drug design approach. J Med Chem. 2008 Oct 9;51(19):6138-49. DM1325C RU https://pubmed.ncbi.nlm.nih.gov/18763754 DMYN6Z9 DI DMYN6Z9 DMYN6Z9 DN 3-(3-benzylamino)-piperidin-2-one DMYN6Z9 MI TTZ9SOR DMYN6Z9 MN Muscarinic acetylcholine receptor M1 (CHRM1) DMYN6Z9 MT DTT DMYN6Z9 MA Inhibitor DMYN6Z9 RN Designing active template molecules by combining computational de novo design and human chemist's expertise. J Med Chem. 2007 Apr 19;50(8):1925-32. DMYN6Z9 RU https://pubmed.ncbi.nlm.nih.gov/17367122 DMYN6Z9 DI DMYN6Z9 DMYN6Z9 DN 3-(3-benzylamino)-piperidin-2-one DMYN6Z9 MI TTYEG6Q DMYN6Z9 MN Muscarinic acetylcholine receptor M2 (CHRM2) DMYN6Z9 MT DTT DMYN6Z9 MA Inhibitor DMYN6Z9 RN Designing active template molecules by combining computational de novo design and human chemist's expertise. J Med Chem. 2007 Apr 19;50(8):1925-32. DMYN6Z9 RU https://pubmed.ncbi.nlm.nih.gov/17367122 DMYN6Z9 DI DMYN6Z9 DMYN6Z9 DN 3-(3-benzylamino)-piperidin-2-one DMYN6Z9 MI TTQ13Z5 DMYN6Z9 MN Muscarinic acetylcholine receptor M3 (CHRM3) DMYN6Z9 MT DTT DMYN6Z9 MA Inhibitor DMYN6Z9 RN Designing active template molecules by combining computational de novo design and human chemist's expertise. J Med Chem. 2007 Apr 19;50(8):1925-32. DMYN6Z9 RU https://pubmed.ncbi.nlm.nih.gov/17367122 DMYN6Z9 DI DMYN6Z9 DMYN6Z9 DN 3-(3-benzylamino)-piperidin-2-one DMYN6Z9 MI TTQ3JTF DMYN6Z9 MN Muscarinic acetylcholine receptor M4 (CHRM4) DMYN6Z9 MT DTT DMYN6Z9 MA Inhibitor DMYN6Z9 RN Designing active template molecules by combining computational de novo design and human chemist's expertise. J Med Chem. 2007 Apr 19;50(8):1925-32. DMYN6Z9 RU https://pubmed.ncbi.nlm.nih.gov/17367122 DMYN6Z9 DI DMYN6Z9 DMYN6Z9 DN 3-(3-benzylamino)-piperidin-2-one DMYN6Z9 MI TTH18TF DMYN6Z9 MN Muscarinic acetylcholine receptor M5 (CHRM5) DMYN6Z9 MT DTT DMYN6Z9 MA Inhibitor DMYN6Z9 RN Designing active template molecules by combining computational de novo design and human chemist's expertise. J Med Chem. 2007 Apr 19;50(8):1925-32. DMYN6Z9 RU https://pubmed.ncbi.nlm.nih.gov/17367122 DM9S36A DI DM9S36A DM9S36A DN 3-(3-Benzylnaphthalen-2-yl)pyridine DM9S36A MI TTIQUX7 DM9S36A MN Steroid 11-beta-hydroxylase (CYP11B1) DM9S36A MT DTT DM9S36A MA Inhibitor DM9S36A RN Novel aldosterone synthase inhibitors with extended carbocyclic skeleton by a combined ligand-based and structure-based drug design approach. J Med Chem. 2008 Oct 9;51(19):6138-49. DM9S36A RU https://pubmed.ncbi.nlm.nih.gov/18763754 DMFPTXO DI DMFPTXO DMFPTXO DN 3-(3-bromophenylethynyl)-5-methyl[1,2,4]triazine DMFPTXO MI TTHS256 DMFPTXO MN Metabotropic glutamate receptor 5 (mGluR5) DMFPTXO MT DTT DMFPTXO MA Inhibitor DMFPTXO RN Synthesis and pharmacological evaluation of phenylethynyl[1,2,4]methyltriazines as analogues of 3-methyl-6-(phenylethynyl)pyridine. J Med Chem. 2007 Jul 12;50(14):3388-91. DMFPTXO RU https://pubmed.ncbi.nlm.nih.gov/17569516 DMSJGQE DI DMSJGQE DMSJGQE DN 3-(3-Carboxy-propionylamino)-benzoic acid DMSJGQE MI TT1RS9F DMSJGQE MN Acetylcholinesterase (AChE) DMSJGQE MT DTT DMSJGQE MA Inhibitor DMSJGQE RN Synthesis, anticholinesterase activity and structure-activity relationships of m-Aminobenzoic acid derivatives. Bioorg Med Chem Lett. 2003 May 19;13(10):1825-7. DMSJGQE RU https://pubmed.ncbi.nlm.nih.gov/12729674 DMI2RH1 DI DMI2RH1 DMI2RH1 DN 3-(3-chloro-1H-pyrazol-5-yl)quinoxalin-2(1H)-one DMI2RH1 MI TTK25J1 DMI2RH1 MN Adenosine A1 receptor (ADORA1) DMI2RH1 MT DTT DMI2RH1 MA Inhibitor DMI2RH1 RN Derivatives of 4-amino-6-hydroxy-2-mercaptopyrimidine as novel, potent, and selective A3 adenosine receptor antagonists. J Med Chem. 2008 Mar 27;51(6):1764-70. DMI2RH1 RU https://pubmed.ncbi.nlm.nih.gov/18269230 DMI2RH1 DI DMI2RH1 DMI2RH1 DN 3-(3-chloro-1H-pyrazol-5-yl)quinoxalin-2(1H)-one DMI2RH1 MI TTJFY5U DMI2RH1 MN Adenosine A3 receptor (ADORA3) DMI2RH1 MT DTT DMI2RH1 MA Inhibitor DMI2RH1 RN Derivatives of 4-amino-6-hydroxy-2-mercaptopyrimidine as novel, potent, and selective A3 adenosine receptor antagonists. J Med Chem. 2008 Mar 27;51(6):1764-70. DMI2RH1 RU https://pubmed.ncbi.nlm.nih.gov/18269230 DMD4O6V DI DMD4O6V DMD4O6V DN 3-(3-Chloro-phenyl)-5,7-dihydroxy-chromen-4-one DMD4O6V MI TTGKNB4 DMD4O6V MN Epidermal growth factor receptor (EGFR) DMD4O6V MT DTT DMD4O6V MA Inhibitor DMD4O6V RN Use of a pharmacophore model for the design of EGFR tyrosine kinase inhibitors: isoflavones and 3-phenyl-4(1H)-quinolones. J Med Chem. 1999 Mar 25;42(6):1018-26. DMD4O6V RU https://pubmed.ncbi.nlm.nih.gov/10090785 DMGJS9N DI DMGJS9N DMGJS9N DN 3-(3-cyano-1H-indol-6-yl)-1-methyl-1-phenylurea DMGJS9N MI TTTB4UP DMGJS9N MN Inosine-5'-monophosphate dehydrogenase 2 (IMPDH2) DMGJS9N MT DTT DMGJS9N MA Inhibitor DMGJS9N RN Novel indole inhibitors of IMPDH from fragments: synthesis and initial structure-activity relationships. Bioorg Med Chem Lett. 2006 May 1;16(9):2539-42. DMGJS9N RU https://pubmed.ncbi.nlm.nih.gov/16483773 DM0O2ZB DI DM0O2ZB DM0O2ZB DN 3-(3-Dimethylamino-propyl)-1H-indol-4-ol DM0O2ZB MI TTJQOD7 DM0O2ZB MN 5-HT 2A receptor (HTR2A) DM0O2ZB MT DTT DM0O2ZB MA Inhibitor DM0O2ZB RN SAR of psilocybin analogs: discovery of a selective 5-HT 2C agonist. Bioorg Med Chem Lett. 2005 Oct 15;15(20):4555-9. DM0O2ZB RU https://pubmed.ncbi.nlm.nih.gov/16061378 DM0O2ZB DI DM0O2ZB DM0O2ZB DN 3-(3-Dimethylamino-propyl)-1H-indol-4-ol DM0O2ZB MI TT0K1SC DM0O2ZB MN 5-HT 2B receptor (HTR2B) DM0O2ZB MT DTT DM0O2ZB MA Inhibitor DM0O2ZB RN SAR of psilocybin analogs: discovery of a selective 5-HT 2C agonist. Bioorg Med Chem Lett. 2005 Oct 15;15(20):4555-9. DM0O2ZB RU https://pubmed.ncbi.nlm.nih.gov/16061378 DM0O2ZB DI DM0O2ZB DM0O2ZB DN 3-(3-Dimethylamino-propyl)-1H-indol-4-ol DM0O2ZB MI TTWJBZ5 DM0O2ZB MN 5-HT 2C receptor (HTR2C) DM0O2ZB MT DTT DM0O2ZB MA Inhibitor DM0O2ZB RN SAR of psilocybin analogs: discovery of a selective 5-HT 2C agonist. Bioorg Med Chem Lett. 2005 Oct 15;15(20):4555-9. DM0O2ZB RU https://pubmed.ncbi.nlm.nih.gov/16061378 DM0ZHJQ DI DM0ZHJQ DM0ZHJQ DN 3-(3-Fluoro-phenyl)-6,7-dimethoxy-quinoline DM0ZHJQ MI TT8FYO9 DM0ZHJQ MN Platelet-derived growth factor receptor alpha (PDGFRA) DM0ZHJQ MT DTT DM0ZHJQ MA Inhibitor DM0ZHJQ RN A new series of PDGF receptor tyrosine kinase inhibitors: 3-substituted quinoline derivatives. J Med Chem. 1994 Jul 8;37(14):2129-37. DM0ZHJQ RU https://pubmed.ncbi.nlm.nih.gov/8035419 DM0ZHJQ DI DM0ZHJQ DM0ZHJQ DN 3-(3-Fluoro-phenyl)-6,7-dimethoxy-quinoline DM0ZHJQ MI TTI7421 DM0ZHJQ MN Platelet-derived growth factor receptor beta (PDGFRB) DM0ZHJQ MT DTT DM0ZHJQ MA Inhibitor DM0ZHJQ RN A new series of PDGF receptor tyrosine kinase inhibitors: 3-substituted quinoline derivatives. J Med Chem. 1994 Jul 8;37(14):2129-37. DM0ZHJQ RU https://pubmed.ncbi.nlm.nih.gov/8035419 DM7FQVC DI DM7FQVC DM7FQVC DN 3-(3'-furyl)-aniline DM7FQVC MI TTAWNKZ DM7FQVC MN Norepinephrine transporter (NET) DM7FQVC MT DTT DM7FQVC MA Inhibitor DM7FQVC RN Designing active template molecules by combining computational de novo design and human chemist's expertise. J Med Chem. 2007 Apr 19;50(8):1925-32. DM7FQVC RU https://pubmed.ncbi.nlm.nih.gov/17367122 DMP0DQE DI DMP0DQE DMP0DQE DN 3-(3-hydroxyphenyl)quinolin-7-ol DMP0DQE MI TTIWB6L DMP0DQE MN Estradiol 17 beta-dehydrogenase 1 (17-beta-HSD1) DMP0DQE MT DTT DMP0DQE MA Inhibitor DMP0DQE RN Design, synthesis, and biological evaluation of (hydroxyphenyl)naphthalene and -quinoline derivatives: potent and selective nonsteroidal inhibitors... J Med Chem. 2008 Apr 10;51(7):2158-69. DMP0DQE RU https://pubmed.ncbi.nlm.nih.gov/18324762 DMRDS1U DI DMRDS1U DMRDS1U DN 3-(3-Methanesulfonyl-phenyl)-1-propyl-pyrrolidine DMRDS1U MI TTSQIFT DMRDS1U MN 5-HT 1A receptor (HTR1A) DMRDS1U MT DTT DMRDS1U MA Inhibitor DMRDS1U RN Regioselective synthesis of 3-aryl substituted pyrrolidines via palladium catalyzed arylation: pharmacological evaluation for central dopaminergic and serotonergic activity, Bioorg. Med. Chem. Lett. 7(3):241-246 (1997). DMRDS1U RU http://www.sciencedirect.com/science/article/pii/S0960894X9600618X DMU53NZ DI DMU53NZ DMU53NZ DN 3-(3-methoxybenzyl)-1H-pyrrolo[2,3-b]pyridine DMU53NZ MI TTRLW2X DMU53NZ MN Fibroblast growth factor receptor 1 (FGFR1) DMU53NZ MT DTT DMU53NZ MA Inhibitor DMU53NZ RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DMU53NZ RU https://pubmed.ncbi.nlm.nih.gov/10592235 DMZQ2CJ DI DMZQ2CJ DMZQ2CJ DN 3-(3-methoxyphenyl)-6-methyl-2H-chromen-2-one DMZQ2CJ MI TTGP7BY DMZQ2CJ MN Monoamine oxidase type B (MAO-B) DMZQ2CJ MT DTT DMZQ2CJ MA Inhibitor DMZQ2CJ RN Synthesis and evaluation of 6-methyl-3-phenylcoumarins as potent and selective MAO-B inhibitors. Bioorg Med Chem Lett. 2009 Sep 1;19(17):5053-5. DMZQ2CJ RU https://pubmed.ncbi.nlm.nih.gov/19628387 DM2YLBD DI DM2YLBD DM2YLBD DN 3-(3-methyl-3,4-dihydronaphthalen-2-yl)pyridine DM2YLBD MI TTSZLWK DM2YLBD MN Aromatase (CYP19A1) DM2YLBD MT DTT DM2YLBD MA Inhibitor DM2YLBD RN Synthesis and evaluation of heteroaryl-substituted dihydronaphthalenes and indenes: potent and selective inhibitors of aldosterone synthase (CYP11B... J Med Chem. 2006 Apr 6;49(7):2222-31. DM2YLBD RU https://pubmed.ncbi.nlm.nih.gov/16570918 DM2YLBD DI DM2YLBD DM2YLBD DN 3-(3-methyl-3,4-dihydronaphthalen-2-yl)pyridine DM2YLBD MI TTIQUX7 DM2YLBD MN Steroid 11-beta-hydroxylase (CYP11B1) DM2YLBD MT DTT DM2YLBD MA Inhibitor DM2YLBD RN Synthesis and evaluation of heteroaryl-substituted dihydronaphthalenes and indenes: potent and selective inhibitors of aldosterone synthase (CYP11B... J Med Chem. 2006 Apr 6;49(7):2222-31. DM2YLBD RU https://pubmed.ncbi.nlm.nih.gov/16570918 DMTNCXP DI DMTNCXP DMTNCXP DN 3-(3-Methyl-butoxy)-9H-beta-carboline DMTNCXP MI TT1MPAY DMTNCXP MN GABA(A) receptor alpha-1 (GABRA1) DMTNCXP MT DTT DMTNCXP MA Inhibitor DMTNCXP RN Predictive binding of beta-carboline inverse agonists and antagonists via the CoMFA/GOLPE approach. J Med Chem. 1992 Oct 30;35(22):4001-10. DMTNCXP RU https://pubmed.ncbi.nlm.nih.gov/1331452 DMTNCXP DI DMTNCXP DMTNCXP DN 3-(3-Methyl-butoxy)-9H-beta-carboline DMTNCXP MI TTBMV1G DMTNCXP MN GABA(A) receptor alpha-2 (GABRA2) DMTNCXP MT DTT DMTNCXP MA Inhibitor DMTNCXP RN Design, synthesis, and subtype selectivity of 3,6-disubstituted -carbolines at Bz/GABA(A)ergic receptors. SAR and studies directed toward agents f... Bioorg Med Chem. 2010 Nov 1;18(21):7548-64. DMTNCXP RU https://pubmed.ncbi.nlm.nih.gov/20888240 DMTNCXP DI DMTNCXP DMTNCXP DN 3-(3-Methyl-butoxy)-9H-beta-carboline DMTNCXP MI TT37EDJ DMTNCXP MN GABA(A) receptor alpha-3 (GABRA3) DMTNCXP MT DTT DMTNCXP MA Inhibitor DMTNCXP RN Design, synthesis, and subtype selectivity of 3,6-disubstituted -carbolines at Bz/GABA(A)ergic receptors. SAR and studies directed toward agents f... Bioorg Med Chem. 2010 Nov 1;18(21):7548-64. DMTNCXP RU https://pubmed.ncbi.nlm.nih.gov/20888240 DMTNCXP DI DMTNCXP DMTNCXP DN 3-(3-Methyl-butoxy)-9H-beta-carboline DMTNCXP MI TTNZPQ1 DMTNCXP MN GABA(A) receptor alpha-5 (GABRA5) DMTNCXP MT DTT DMTNCXP MA Inhibitor DMTNCXP RN Design, synthesis, and subtype selectivity of 3,6-disubstituted -carbolines at Bz/GABA(A)ergic receptors. SAR and studies directed toward agents f... Bioorg Med Chem. 2010 Nov 1;18(21):7548-64. DMTNCXP RU https://pubmed.ncbi.nlm.nih.gov/20888240 DMTNCXP DI DMTNCXP DMTNCXP DN 3-(3-Methyl-butoxy)-9H-beta-carboline DMTNCXP MI TT06RH5 DMTNCXP MN GABA(A) receptor gamma-2 (GABRG2) DMTNCXP MT DTT DMTNCXP MA Inhibitor DMTNCXP RN Design, synthesis, and subtype selectivity of 3,6-disubstituted -carbolines at Bz/GABA(A)ergic receptors. SAR and studies directed toward agents f... Bioorg Med Chem. 2010 Nov 1;18(21):7548-64. DMTNCXP RU https://pubmed.ncbi.nlm.nih.gov/20888240 DMTNCXP DI DMTNCXP DMTNCXP DN 3-(3-Methyl-butoxy)-9H-beta-carboline DMTNCXP MI TTNJYV2 DMTNCXP MN Gamma-aminobutyric acid receptor (GAR) DMTNCXP MT DTT DMTNCXP MA Inhibitor DMTNCXP RN Predictive binding of beta-carboline inverse agonists and antagonists via the CoMFA/GOLPE approach. J Med Chem. 1992 Oct 30;35(22):4001-10. DMTNCXP RU https://pubmed.ncbi.nlm.nih.gov/1331452 DMXAD0R DI DMXAD0R DMXAD0R DN 3-(3-methylphenylethynyl)-5-methyl[1,2,4]triazine DMXAD0R MI TTHS256 DMXAD0R MN Metabotropic glutamate receptor 5 (mGluR5) DMXAD0R MT DTT DMXAD0R MA Inhibitor DMXAD0R RN Synthesis and pharmacological evaluation of phenylethynyl[1,2,4]methyltriazines as analogues of 3-methyl-6-(phenylethynyl)pyridine. J Med Chem. 2007 Jul 12;50(14):3388-91. DMXAD0R RU https://pubmed.ncbi.nlm.nih.gov/17569516 DMHU9V5 DI DMHU9V5 DMHU9V5 DN 3-(3-methylthiophen-2-yl)pyridine DMHU9V5 MI TTXV4FI DMHU9V5 MN Albendazole monooxygenase (CYP3A4) DMHU9V5 MT DTT DMHU9V5 MA Inhibitor DMHU9V5 RN Synthetic inhibitors of cytochrome P-450 2A6: inhibitory activity, difference spectra, mechanism of inhibition, and protein cocrystallization. J Med Chem. 2006 Nov 30;49(24):6987-7001. DMHU9V5 RU https://pubmed.ncbi.nlm.nih.gov/17125252 DM314ZE DI DM314ZE DM314ZE DN 3-(3-Phenyl-ureido)-benzenesulfonamide DM314ZE MI TTHQPL7 DM314ZE MN Carbonic anhydrase I (CA-I) DM314ZE MT DTT DM314ZE MA Inhibitor DM314ZE RN Carbonic anhydrase inhibitors: inhibition of the tumor-associated isozymes IX and XII with a library of aromatic and heteroaromatic sulfonamides. Bioorg Med Chem Lett. 2005 Nov 1;15(21):4862-6. DM314ZE RU https://pubmed.ncbi.nlm.nih.gov/16168653 DM314ZE DI DM314ZE DM314ZE DN 3-(3-Phenyl-ureido)-benzenesulfonamide DM314ZE MI TTANPDJ DM314ZE MN Carbonic anhydrase II (CA-II) DM314ZE MT DTT DM314ZE MA Inhibitor DM314ZE RN Carbonic anhydrase inhibitors: inhibition of the tumor-associated isozymes IX and XII with a library of aromatic and heteroaromatic sulfonamides. Bioorg Med Chem Lett. 2005 Nov 1;15(21):4862-6. DM314ZE RU https://pubmed.ncbi.nlm.nih.gov/16168653 DM314ZE DI DM314ZE DM314ZE DN 3-(3-Phenyl-ureido)-benzenesulfonamide DM314ZE MI TT2LVK8 DM314ZE MN Carbonic anhydrase IX (CA-IX) DM314ZE MT DTT DM314ZE MA Inhibitor DM314ZE RN Carbonic anhydrase inhibitors: inhibition of the tumor-associated isozymes IX and XII with a library of aromatic and heteroaromatic sulfonamides. Bioorg Med Chem Lett. 2005 Nov 1;15(21):4862-6. DM314ZE RU https://pubmed.ncbi.nlm.nih.gov/16168653 DM314ZE DI DM314ZE DM314ZE DN 3-(3-Phenyl-ureido)-benzenesulfonamide DM314ZE MI TTSYM0R DM314ZE MN Carbonic anhydrase XII (CA-XII) DM314ZE MT DTT DM314ZE MA Inhibitor DM314ZE RN Carbonic anhydrase inhibitors: inhibition of the tumor-associated isozymes IX and XII with a library of aromatic and heteroaromatic sulfonamides. Bioorg Med Chem Lett. 2005 Nov 1;15(21):4862-6. DM314ZE RU https://pubmed.ncbi.nlm.nih.gov/16168653 DMU52WA DI DMU52WA DMU52WA DN 3-(3-Pyridin-2-yl-pyrazol-1-yl)-benzonitrile DMU52WA MI TTHS256 DMU52WA MN Metabotropic glutamate receptor 5 (mGluR5) DMU52WA MT DTT DMU52WA MA Inhibitor DMU52WA RN Discovery of novel heteroarylazoles that are metabotropic glutamate subtype 5 receptor antagonists with anxiolytic activity. J Med Chem. 2004 Sep 9;47(19):4645-8. Letter DMU52WA RU https://pubmed.ncbi.nlm.nih.gov/15341479 DMZLT24 DI DMZLT24 DMZLT24 DN 3-(3-Pyridin-2-yl-pyrrol-1-yl)-benzonitrile DMZLT24 MI TTHS256 DMZLT24 MN Metabotropic glutamate receptor 5 (mGluR5) DMZLT24 MT DTT DMZLT24 MA Inhibitor DMZLT24 RN Discovery of novel heteroarylazoles that are metabotropic glutamate subtype 5 receptor antagonists with anxiolytic activity. J Med Chem. 2004 Sep 9;47(19):4645-8. Letter DMZLT24 RU https://pubmed.ncbi.nlm.nih.gov/15341479 DMQDPHT DI DMQDPHT DMQDPHT DN 3-(4-(2-phenylethynyl)benzoyl)pentanoic acid DMQDPHT MI TTXZ0KQ DMQDPHT MN Matrix metalloproteinase-12 (MMP-12) DMQDPHT MT DTT DMQDPHT MA Inhibitor DMQDPHT RN Selective inhibition of matrix metalloproteinase isozymes and in vivo protection against emphysema by substituted gamma-keto carboxylic acids. J Med Chem. 2006 Jan 26;49(2):456-8. DMQDPHT RU https://pubmed.ncbi.nlm.nih.gov/16420030 DMQDPHT DI DMQDPHT DMQDPHT DN 3-(4-(2-phenylethynyl)benzoyl)pentanoic acid DMQDPHT MI TTLM12X DMQDPHT MN Matrix metalloproteinase-2 (MMP-2) DMQDPHT MT DTT DMQDPHT MA Inhibitor DMQDPHT RN Selective inhibition of matrix metalloproteinase isozymes and in vivo protection against emphysema by substituted gamma-keto carboxylic acids. J Med Chem. 2006 Jan 26;49(2):456-8. DMQDPHT RU https://pubmed.ncbi.nlm.nih.gov/16420030 DMQDPHT DI DMQDPHT DMQDPHT DN 3-(4-(2-phenylethynyl)benzoyl)pentanoic acid DMQDPHT MI TTYRF5E DMQDPHT MN Matrix metalloproteinase-21 (MMP-21) DMQDPHT MT DTT DMQDPHT MA Inhibitor DMQDPHT RN Selective inhibition of matrix metalloproteinase isozymes and in vivo protection against emphysema by substituted gamma-keto carboxylic acids. J Med Chem. 2006 Jan 26;49(2):456-8. DMQDPHT RU https://pubmed.ncbi.nlm.nih.gov/16420030 DMQDPHT DI DMQDPHT DMQDPHT DN 3-(4-(2-phenylethynyl)benzoyl)pentanoic acid DMQDPHT MI TT6X50U DMQDPHT MN Matrix metalloproteinase-9 (MMP-9) DMQDPHT MT DTT DMQDPHT MA Inhibitor DMQDPHT RN Selective inhibition of matrix metalloproteinase isozymes and in vivo protection against emphysema by substituted gamma-keto carboxylic acids. J Med Chem. 2006 Jan 26;49(2):456-8. DMQDPHT RU https://pubmed.ncbi.nlm.nih.gov/16420030 DM1GVE8 DI DM1GVE8 DM1GVE8 DN 3-(4-(4-hydroxyphenyl)phthalazin-1-ylamino)phenol DM1GVE8 MI TTXWASR DM1GVE8 MN Intestinal maltase-glucoamylase (MGAM) DM1GVE8 MT DTT DM1GVE8 MA Inhibitor DM1GVE8 RN Discovery of novel alpha-glucosidase inhibitors based on the virtual screening with the homology-modeled protein structure. Bioorg Med Chem. 2008 Jan 1;16(1):284-92. DM1GVE8 RU https://pubmed.ncbi.nlm.nih.gov/17920282 DM8EH07 DI DM8EH07 DM8EH07 DN 3-(4-(4-Hydroxyphenyl)thiazol-2-ylamino)phenol DM8EH07 MI TTWHDVK DM8EH07 MN Fructose-1,6-bisphosphatase (FBP) DM8EH07 MT DTT DM8EH07 MA Inhibitor DM8EH07 RN A library of novel allosteric inhibitors against fructose 1,6-bisphosphatase. Bioorg Med Chem. 2009 Jun 1;17(11):3916-22. DM8EH07 RU https://pubmed.ncbi.nlm.nih.gov/19419876 DM36VA0 DI DM36VA0 DM36VA0 DN 3-(4-(benzyloxy)-3,5-dibromophenyl)propanoic acid DM36VA0 MI TTTSEPU DM36VA0 MN Thyroid hormone receptor alpha (THRA) DM36VA0 MT DTT DM36VA0 MA Inhibitor DM36VA0 RN Thyroid receptor ligands. Part 7: Indirect antagonists of the thyroid hormone receptor with improved affinity. Bioorg Med Chem Lett. 2007 Apr 1;17(7):2018-21. DM36VA0 RU https://pubmed.ncbi.nlm.nih.gov/17254783 DM36VA0 DI DM36VA0 DM36VA0 DN 3-(4-(benzyloxy)-3,5-dibromophenyl)propanoic acid DM36VA0 MI TTGER3L DM36VA0 MN Thyroid hormone receptor beta (THRB) DM36VA0 MT DTT DM36VA0 MA Inhibitor DM36VA0 RN Thyroid receptor ligands. Part 7: Indirect antagonists of the thyroid hormone receptor with improved affinity. Bioorg Med Chem Lett. 2007 Apr 1;17(7):2018-21. DM36VA0 RU https://pubmed.ncbi.nlm.nih.gov/17254783 DMX6ZHQ DI DMX6ZHQ DMX6ZHQ DN 3-(4-(o-toluidino)pyrimidin-2-ylamino)benzamide DMX6ZHQ MI TT860QF DMX6ZHQ MN LCK tyrosine protein kinase (LCK) DMX6ZHQ MT DTT DMX6ZHQ MA Inhibitor DMX6ZHQ RN N-4-Pyrimidinyl-1H-indazol-4-amine inhibitors of Lck: indazoles as phenol isosteres with improved pharmacokinetics. Bioorg Med Chem Lett. 2007 Aug 1;17(15):4363-8. DMX6ZHQ RU https://pubmed.ncbi.nlm.nih.gov/17600705 DMGXPJV DI DMGXPJV DMGXPJV DN 3-(4,5-Bis-biphenyl-4-yl-1H-imidazol-2-yl)-phenol DMGXPJV MI TTELIN2 DMGXPJV MN PTPN1 messenger RNA (PTPN1 mRNA) DMGXPJV MT DTT DMGXPJV MA Inhibitor DMGXPJV RN Molecular docking and high-throughput screening for novel inhibitors of protein tyrosine phosphatase-1B. J Med Chem. 2002 May 23;45(11):2213-21. DMGXPJV RU https://pubmed.ncbi.nlm.nih.gov/12014959 DMONSM1 DI DMONSM1 DMONSM1 DN 3-(4,5-Dihydrooxazol-2-yl)phenyl propylcarbamate DMONSM1 MI TTDP1UC DMONSM1 MN Fatty acid amide hydrolase (FAAH) DMONSM1 MT DTT DMONSM1 MA Inhibitor DMONSM1 RN Chiral 3-(4,5-dihydrooxazol-2-yl)phenyl alkylcarbamates as novel FAAH inhibitors: Insight into FAAH enantioselectivity by molecular docking and int... Eur J Med Chem. 2009 Oct;44(10):4179-91. DMONSM1 RU https://pubmed.ncbi.nlm.nih.gov/19539407 DMS1LDH DI DMS1LDH DMS1LDH DN 3-(4-Amino-phenyl)-1-methyl-pyrrolidine-2,5-dione DMS1LDH MI TTSZLWK DMS1LDH MN Aromatase (CYP19A1) DMS1LDH MT DTT DMS1LDH MA Inhibitor DMS1LDH RN Synthesis and biochemical evaluation of analogues of aminoglutethimide based on phenylpyrrolidine-2,5-dione. J Med Chem. 1986 Apr;29(4):520-3. DMS1LDH RU https://pubmed.ncbi.nlm.nih.gov/3754286 DMD5YKO DI DMD5YKO DMD5YKO DN 3-(4-Amino-phenyl)-3-butyl-piperidine-2,6-dione DMD5YKO MI TTSZLWK DMD5YKO MN Aromatase (CYP19A1) DMD5YKO MT DTT DMD5YKO MA Inhibitor DMD5YKO RN Aromatase inhibitors. Synthesis and evaluation of mammary tumor inhibiting activity of 3-alkylated 3-(4-aminophenyl)piperidine-2,6-diones. J Med Chem. 1986 Aug;29(8):1362-9. DMD5YKO RU https://pubmed.ncbi.nlm.nih.gov/3735304 DMD5YKO DI DMD5YKO DMD5YKO DN 3-(4-Amino-phenyl)-3-butyl-piperidine-2,6-dione DMD5YKO MI TTSYVO6 DMD5YKO MN Cholesterol desmolase (CYP11A1) DMD5YKO MT DTT DMD5YKO MA Inhibitor DMD5YKO RN Aromatase inhibitors. Synthesis and evaluation of mammary tumor inhibiting activity of 3-alkylated 3-(4-aminophenyl)piperidine-2,6-diones. J Med Chem. 1986 Aug;29(8):1362-9. DMD5YKO RU https://pubmed.ncbi.nlm.nih.gov/3735304 DM3I15D DI DM3I15D DM3I15D DN 3-(4-Amino-phenyl)-3-ethyl-pyrrolidine-2,5-dione DM3I15D MI TTSZLWK DM3I15D MN Aromatase (CYP19A1) DM3I15D MT DTT DM3I15D MA Inhibitor DM3I15D RN Synthesis and biochemical evaluation of analogues of aminoglutethimide based on phenylpyrrolidine-2,5-dione. J Med Chem. 1986 Apr;29(4):520-3. DM3I15D RU https://pubmed.ncbi.nlm.nih.gov/3754286 DMZ86CS DI DMZ86CS DMZ86CS DN 3-(4-Amino-phenyl)-3-heptyl-piperidine-2,6-dione DMZ86CS MI TTSZLWK DMZ86CS MN Aromatase (CYP19A1) DMZ86CS MT DTT DMZ86CS MA Inhibitor DMZ86CS RN Aromatase inhibitors. Synthesis and evaluation of mammary tumor inhibiting activity of 3-alkylated 3-(4-aminophenyl)piperidine-2,6-diones. J Med Chem. 1986 Aug;29(8):1362-9. DMZ86CS RU https://pubmed.ncbi.nlm.nih.gov/3735304 DMW62U8 DI DMW62U8 DMW62U8 DN 3-(4-Amino-phenyl)-3-hexyl-piperidine-2,6-dione DMW62U8 MI TTSZLWK DMW62U8 MN Aromatase (CYP19A1) DMW62U8 MT DTT DMW62U8 MA Inhibitor DMW62U8 RN Aromatase inhibitors. Synthesis and evaluation of mammary tumor inhibiting activity of 3-alkylated 3-(4-aminophenyl)piperidine-2,6-diones. J Med Chem. 1986 Aug;29(8):1362-9. DMW62U8 RU https://pubmed.ncbi.nlm.nih.gov/3735304 DMITHX5 DI DMITHX5 DMITHX5 DN 3-(4-Amino-phenyl)-3-methyl-pyrrolidine-2,5-dione DMITHX5 MI TTSZLWK DMITHX5 MN Aromatase (CYP19A1) DMITHX5 MT DTT DMITHX5 MA Inhibitor DMITHX5 RN Synthesis and biochemical evaluation of analogues of aminoglutethimide based on phenylpyrrolidine-2,5-dione. J Med Chem. 1986 Apr;29(4):520-3. DMITHX5 RU https://pubmed.ncbi.nlm.nih.gov/3754286 DM20DXS DI DM20DXS DM20DXS DN 3-(4-Amino-phenyl)-3-pentyl-piperidine-2,6-dione DM20DXS MI TTSZLWK DM20DXS MN Aromatase (CYP19A1) DM20DXS MT DTT DM20DXS MA Inhibitor DM20DXS RN Aromatase inhibitors. Synthesis and evaluation of mammary tumor inhibiting activity of 3-alkylated 3-(4-aminophenyl)piperidine-2,6-diones. J Med Chem. 1986 Aug;29(8):1362-9. DM20DXS RU https://pubmed.ncbi.nlm.nih.gov/3735304 DM20DXS DI DM20DXS DM20DXS DN 3-(4-Amino-phenyl)-3-pentyl-piperidine-2,6-dione DM20DXS MI TTSYVO6 DM20DXS MN Cholesterol desmolase (CYP11A1) DM20DXS MT DTT DM20DXS MA Inhibitor DM20DXS RN Aromatase inhibitors. Synthesis and evaluation of mammary tumor inhibiting activity of 3-alkylated 3-(4-aminophenyl)piperidine-2,6-diones. J Med Chem. 1986 Aug;29(8):1362-9. DM20DXS RU https://pubmed.ncbi.nlm.nih.gov/3735304 DM39XMT DI DM39XMT DM39XMT DN 3-(4-Amino-phenyl)-3-propyl-piperidine-2,6-dione DM39XMT MI TTSZLWK DM39XMT MN Aromatase (CYP19A1) DM39XMT MT DTT DM39XMT MA Inhibitor DM39XMT RN Aromatase inhibitors. Synthesis and evaluation of mammary tumor inhibiting activity of 3-alkylated 3-(4-aminophenyl)piperidine-2,6-diones. J Med Chem. 1986 Aug;29(8):1362-9. DM39XMT RU https://pubmed.ncbi.nlm.nih.gov/3735304 DMVN0O5 DI DMVN0O5 DMVN0O5 DN 3-(4-Amino-phenyl)-pyrrolidine-2,5-dione DMVN0O5 MI TTSZLWK DMVN0O5 MN Aromatase (CYP19A1) DMVN0O5 MT DTT DMVN0O5 MA Inhibitor DMVN0O5 RN Synthesis and biochemical evaluation of analogues of aminoglutethimide based on phenylpyrrolidine-2,5-dione. J Med Chem. 1986 Apr;29(4):520-3. DMVN0O5 RU https://pubmed.ncbi.nlm.nih.gov/3754286 DM6XTBI DI DM6XTBI DM6XTBI DN 3-(4-aminophenyl)quinoxaline-5-carboxamide DM6XTBI MI TTVDSZ0 DM6XTBI MN Poly [ADP-ribose] polymerase 1 (PARP1) DM6XTBI MT DTT DM6XTBI MA Inhibitor DM6XTBI RN Design, synthesis, and cytoprotective effect of 2-aminothiazole analogues as potent poly(ADP-ribose) polymerase-1 inhibitors. J Med Chem. 2009 Feb 12;52(3):718-25. DM6XTBI RU https://pubmed.ncbi.nlm.nih.gov/19125579 DM30GV2 DI DM30GV2 DM30GV2 DN 3-(4-aminophenyl)thieno[3,2-c]pyridin-4-amine DM30GV2 MI TTUTJGQ DM30GV2 MN Vascular endothelial growth factor receptor 2 (KDR) DM30GV2 MT DTT DM30GV2 MA Inhibitor DM30GV2 RN Thienopyridine urea inhibitors of KDR kinase. Bioorg Med Chem Lett. 2007 Mar 1;17(5):1246-9. DM30GV2 RU https://pubmed.ncbi.nlm.nih.gov/17188869 DMAT7VN DI DMAT7VN DMAT7VN DN 3-(4-Benzoylpiperazine-1-carbonyl)coumarin DMAT7VN MI TT1RS9F DMAT7VN MN Acetylcholinesterase (AChE) DMAT7VN MT DTT DMAT7VN MA Inhibitor DMAT7VN RN Design, synthesis, and acetylcholinesterase inhibitory activity of novel coumarin analogues. Bioorg Med Chem. 2008 Sep 1;16(17):8011-21. DMAT7VN RU https://pubmed.ncbi.nlm.nih.gov/18701305 DMWPB0G DI DMWPB0G DMWPB0G DN 3-(4-Benzyl-piperazin-1-yl)-phenol DMWPB0G MI TTEX248 DMWPB0G MN Dopamine D2 receptor (D2R) DMWPB0G MT DTT DMWPB0G MA Inhibitor DMWPB0G RN New generation dopaminergic agents. 5. Heterocyclic bioisosteres that exploit the 3-OH-N1-phenylpiperazine dopaminergic template. Bioorg Med Chem Lett. 1998 Oct 6;8(19):2675-80. DMWPB0G RU https://pubmed.ncbi.nlm.nih.gov/9873601 DMWPB0G DI DMWPB0G DMWPB0G DN 3-(4-Benzyl-piperazin-1-yl)-phenol DMWPB0G MI TT4C8EA DMWPB0G MN Dopamine D3 receptor (D3R) DMWPB0G MT DTT DMWPB0G MA Inhibitor DMWPB0G RN New generation dopaminergic agents. 5. Heterocyclic bioisosteres that exploit the 3-OH-N1-phenylpiperazine dopaminergic template. Bioorg Med Chem Lett. 1998 Oct 6;8(19):2675-80. DMWPB0G RU https://pubmed.ncbi.nlm.nih.gov/9873601 DMFVCOP DI DMFVCOP DMFVCOP DN 3-(4-Benzyl-piperidin-1-ylmethyl)-chroman-4-one DMFVCOP MI TTSQIFT DMFVCOP MN 5-HT 1A receptor (HTR1A) DMFVCOP MT DTT DMFVCOP MA Inhibitor DMFVCOP RN Synthesis and structure-activity relationships of 1-aralkyl-4-benzylpiperidine and 1-aralkyl-4-benzylpiperazine derivatives as potent sigma ligands. J Med Chem. 2005 Jan 13;48(1):266-73. DMFVCOP RU https://pubmed.ncbi.nlm.nih.gov/15634021 DMFVCOP DI DMFVCOP DMFVCOP DN 3-(4-Benzyl-piperidin-1-ylmethyl)-chroman-4-one DMFVCOP MI TTEX248 DMFVCOP MN Dopamine D2 receptor (D2R) DMFVCOP MT DTT DMFVCOP MA Inhibitor DMFVCOP RN Synthesis and structure-activity relationships of 1-aralkyl-4-benzylpiperidine and 1-aralkyl-4-benzylpiperazine derivatives as potent sigma ligands. J Med Chem. 2005 Jan 13;48(1):266-73. DMFVCOP RU https://pubmed.ncbi.nlm.nih.gov/15634021 DM7LMD6 DI DM7LMD6 DM7LMD6 DN 3-(4-Benzyl-piperidin-1-ylmethyl)-chromen-4-one DM7LMD6 MI TTSQIFT DM7LMD6 MN 5-HT 1A receptor (HTR1A) DM7LMD6 MT DTT DM7LMD6 MA Inhibitor DM7LMD6 RN Synthesis and structure-activity relationships of 1-aralkyl-4-benzylpiperidine and 1-aralkyl-4-benzylpiperazine derivatives as potent sigma ligands. J Med Chem. 2005 Jan 13;48(1):266-73. DM7LMD6 RU https://pubmed.ncbi.nlm.nih.gov/15634021 DMAKMIJ DI DMAKMIJ DMAKMIJ DN 3-(4-bromobenzyl)-1,1-dimethylselenourea DMAKMIJ MI TTAS2UO DMAKMIJ MN Bacterial Urease (Bact ureC) DMAKMIJ MT DTT DMAKMIJ MA Inhibitor DMAKMIJ RN Facile one-pot synthesis of thio and selenourea derivatives: a new class of potent urease inhibitors. Bioorg Med Chem Lett. 2007 Nov 15;17(22):6387-91. DMAKMIJ RU https://pubmed.ncbi.nlm.nih.gov/17889535 DMXMZRE DI DMXMZRE DMXMZRE DN 3-(4-bromophenyl)-1,1-dimethylthiourea DMXMZRE MI TTAS2UO DMXMZRE MN Bacterial Urease (Bact ureC) DMXMZRE MT DTT DMXMZRE MA Inhibitor DMXMZRE RN Facile one-pot synthesis of thio and selenourea derivatives: a new class of potent urease inhibitors. Bioorg Med Chem Lett. 2007 Nov 15;17(22):6387-91. DMXMZRE RU https://pubmed.ncbi.nlm.nih.gov/17889535 DM8W3GC DI DM8W3GC DM8W3GC DN 3-(4-Butoxy-phenyl)-N-hydroxy-N-methyl-acrylamide DM8W3GC MI TT2J34L DM8W3GC MN Arachidonate 5-lipoxygenase (5-LOX) DM8W3GC MT DTT DM8W3GC MA Inhibitor DM8W3GC RN Hydroxamic acid inhibitors of 5-lipoxygenase: quantitative structure-activity relationships. J Med Chem. 1990 Mar;33(3):992-8. DM8W3GC RU https://pubmed.ncbi.nlm.nih.gov/2308149 DMQ2D09 DI DMQ2D09 DMQ2D09 DN 3-(4-chloro-2-cyclohexylphenoxy)propanoic acid DMQ2D09 MI TTQDMX5 DMQ2D09 MN Prostaglandin D2 receptor 2 (PTGDR2) DMQ2D09 MT DTT DMQ2D09 MA Inhibitor DMQ2D09 RN 2-Cycloalkyl phenoxyacetic acid CRTh2 receptor antagonists. Bioorg Med Chem Lett. 2007 Aug 1;17(15):4347-50. DMQ2D09 RU https://pubmed.ncbi.nlm.nih.gov/17531480 DM71EUO DI DM71EUO DM71EUO DN 3-(4-Chlorophenyl)-2-nortropene DM71EUO MI TTVBI8W DM71EUO MN Dopamine transporter (DAT) DM71EUO MT DTT DM71EUO MA Inhibitor DM71EUO RN Synthesis and monoamine transporter affinity of 3alpha-arylmethoxy-3beta-arylnortropanes. Bioorg Med Chem Lett. 2009 Dec 15;19(24):6865-8. DM71EUO RU https://pubmed.ncbi.nlm.nih.gov/19896846 DM71EUO DI DM71EUO DM71EUO DN 3-(4-Chlorophenyl)-2-nortropene DM71EUO MI TT3ROYC DM71EUO MN Serotonin transporter (SERT) DM71EUO MT DTT DM71EUO MA Inhibitor DM71EUO RN Synthesis and monoamine transporter affinity of 3alpha-arylmethoxy-3beta-arylnortropanes. Bioorg Med Chem Lett. 2009 Dec 15;19(24):6865-8. DM71EUO RU https://pubmed.ncbi.nlm.nih.gov/19896846 DM23JIY DI DM23JIY DM23JIY DN 3-(4-cyanophenyl)quinoxaline-5-carboxamide DM23JIY MI TTVDSZ0 DM23JIY MN Poly [ADP-ribose] polymerase 1 (PARP1) DM23JIY MT DTT DM23JIY MA Inhibitor DM23JIY RN Design, synthesis, and cytoprotective effect of 2-aminothiazole analogues as potent poly(ADP-ribose) polymerase-1 inhibitors. J Med Chem. 2009 Feb 12;52(3):718-25. DM23JIY RU https://pubmed.ncbi.nlm.nih.gov/19125579 DMGQE8D DI DMGQE8D DMGQE8D DN 3-(4-cyclohexylthiosemicarbazono)methyl-phenol DMGQE8D MI TTHM0R1 DMGQE8D MN Steryl-sulfatase (STS) DMGQE8D MT DTT DMGQE8D MA Inhibitor DMGQE8D RN Thiosemicarbazones of formyl benzoic acids as novel potent inhibitors of estrone sulfatase. J Med Chem. 2007 Jul 26;50(15):3661-6. DMGQE8D RU https://pubmed.ncbi.nlm.nih.gov/17580843 DM6XC0M DI DM6XC0M DM6XC0M DN 3-(4-dimethylamino-benzylidenyl)-2-indolinone DM6XC0M MI TTI7421 DM6XC0M MN Platelet-derived growth factor receptor beta (PDGFRB) DM6XC0M MT DTT DM6XC0M MA Inhibitor DM6XC0M RN Synthesis and biological activity of N(4)-phenylsubstituted-6-(2,4-dichloro phenylmethyl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamines as vascular endo... Bioorg Med Chem. 2010 May 15;18(10):3575-87. DM6XC0M RU https://pubmed.ncbi.nlm.nih.gov/20403700 DMM7BQP DI DMM7BQP DMM7BQP DN 3-(4-ethyl-3,4-dihydronaphthalen-2-yl)pyridine DMM7BQP MI TTIQUX7 DMM7BQP MN Steroid 11-beta-hydroxylase (CYP11B1) DMM7BQP MT DTT DMM7BQP MA Inhibitor DMM7BQP RN Synthesis and evaluation of heteroaryl-substituted dihydronaphthalenes and indenes: potent and selective inhibitors of aldosterone synthase (CYP11B... J Med Chem. 2006 Apr 6;49(7):2222-31. DMM7BQP RU https://pubmed.ncbi.nlm.nih.gov/16570918 DM8CK9M DI DM8CK9M DM8CK9M DN 3-(4-Fluorophenyl)-2-nortropene DM8CK9M MI TTVBI8W DM8CK9M MN Dopamine transporter (DAT) DM8CK9M MT DTT DM8CK9M MA Inhibitor DM8CK9M RN Synthesis and monoamine transporter affinity of 3alpha-arylmethoxy-3beta-arylnortropanes. Bioorg Med Chem Lett. 2009 Dec 15;19(24):6865-8. DM8CK9M RU https://pubmed.ncbi.nlm.nih.gov/19896846 DM8CK9M DI DM8CK9M DM8CK9M DN 3-(4-Fluorophenyl)-2-nortropene DM8CK9M MI TT3ROYC DM8CK9M MN Serotonin transporter (SERT) DM8CK9M MT DTT DM8CK9M MA Inhibitor DM8CK9M RN Synthesis and monoamine transporter affinity of 3alpha-arylmethoxy-3beta-arylnortropanes. Bioorg Med Chem Lett. 2009 Dec 15;19(24):6865-8. DM8CK9M RU https://pubmed.ncbi.nlm.nih.gov/19896846 DM0POH2 DI DM0POH2 DM0POH2 DN 3-(4-Fluoro-phenyl)-6,7-dimethoxy-quinoline DM0POH2 MI TT8FYO9 DM0POH2 MN Platelet-derived growth factor receptor alpha (PDGFRA) DM0POH2 MT DTT DM0POH2 MA Inhibitor DM0POH2 RN A new series of PDGF receptor tyrosine kinase inhibitors: 3-substituted quinoline derivatives. J Med Chem. 1994 Jul 8;37(14):2129-37. DM0POH2 RU https://pubmed.ncbi.nlm.nih.gov/8035419 DM0POH2 DI DM0POH2 DM0POH2 DN 3-(4-Fluoro-phenyl)-6,7-dimethoxy-quinoline DM0POH2 MI TTI7421 DM0POH2 MN Platelet-derived growth factor receptor beta (PDGFRB) DM0POH2 MT DTT DM0POH2 MA Inhibitor DM0POH2 RN A new series of PDGF receptor tyrosine kinase inhibitors: 3-substituted quinoline derivatives. J Med Chem. 1994 Jul 8;37(14):2129-37. DM0POH2 RU https://pubmed.ncbi.nlm.nih.gov/8035419 DMDYS7Q DI DMDYS7Q DMDYS7Q DN 3-(4-hexylthiosemicarbazono)methyl-benzoic acid DMDYS7Q MI TTHM0R1 DMDYS7Q MN Steryl-sulfatase (STS) DMDYS7Q MT DTT DMDYS7Q MA Inhibitor DMDYS7Q RN Thiosemicarbazones of formyl benzoic acids as novel potent inhibitors of estrone sulfatase. J Med Chem. 2007 Jul 26;50(15):3661-6. DMDYS7Q RU https://pubmed.ncbi.nlm.nih.gov/17580843 DMPS1GW DI DMPS1GW DMPS1GW DN 3-(4H-Imidazol-4-yl)benzenethiol DMPS1GW MI TTZJYKH DMPS1GW MN Indoleamine 2,3-dioxygenase 1 (IDO1) DMPS1GW MT DTT DMPS1GW MA Inhibitor DMPS1GW RN Structure based development of phenylimidazole-derived inhibitors of indoleamine 2,3-dioxygenase. J Med Chem. 2008 Aug 28;51(16):4968-77. DMPS1GW RU https://pubmed.ncbi.nlm.nih.gov/18665584 DME5238 DI DME5238 DME5238 DN 3-(4-Hydroxy-phenyl)-2,3-diphenyl-acrylonitrile DME5238 MI TTFJ8Q1 DME5238 MN Protein kinase C alpha (PRKCA) DME5238 MT DTT DME5238 MA Inhibitor DME5238 RN Multivariate analysis by the minimum spanning tree method of the structural determinants of diphenylethylenes and triphenylacrylonitriles implicate... J Med Chem. 1992 Feb 7;35(3):573-83. DME5238 RU https://pubmed.ncbi.nlm.nih.gov/1738150 DME5238 DI DME5238 DME5238 DN 3-(4-Hydroxy-phenyl)-2,3-diphenyl-acrylonitrile DME5238 MI TTYPXQF DME5238 MN Protein kinase C beta (PRKCB) DME5238 MT DTT DME5238 MA Inhibitor DME5238 RN Multivariate analysis by the minimum spanning tree method of the structural determinants of diphenylethylenes and triphenylacrylonitriles implicate... J Med Chem. 1992 Feb 7;35(3):573-83. DME5238 RU https://pubmed.ncbi.nlm.nih.gov/1738150 DME5238 DI DME5238 DME5238 DN 3-(4-Hydroxy-phenyl)-2,3-diphenyl-acrylonitrile DME5238 MI TT9WJ8U DME5238 MN Protein kinase C delta (PRKCD) DME5238 MT DTT DME5238 MA Inhibitor DME5238 RN Multivariate analysis by the minimum spanning tree method of the structural determinants of diphenylethylenes and triphenylacrylonitriles implicate... J Med Chem. 1992 Feb 7;35(3):573-83. DME5238 RU https://pubmed.ncbi.nlm.nih.gov/1738150 DME5238 DI DME5238 DME5238 DN 3-(4-Hydroxy-phenyl)-2,3-diphenyl-acrylonitrile DME5238 MI TTBZ7OD DME5238 MN Protein kinase C epsilon (PRKCE) DME5238 MT DTT DME5238 MA Inhibitor DME5238 RN Multivariate analysis by the minimum spanning tree method of the structural determinants of diphenylethylenes and triphenylacrylonitriles implicate... J Med Chem. 1992 Feb 7;35(3):573-83. DME5238 RU https://pubmed.ncbi.nlm.nih.gov/1738150 DME5238 DI DME5238 DME5238 DN 3-(4-Hydroxy-phenyl)-2,3-diphenyl-acrylonitrile DME5238 MI TTRFOXJ DME5238 MN Protein kinase C gamma (PRKCG) DME5238 MT DTT DME5238 MA Inhibitor DME5238 RN Multivariate analysis by the minimum spanning tree method of the structural determinants of diphenylethylenes and triphenylacrylonitriles implicate... J Med Chem. 1992 Feb 7;35(3):573-83. DME5238 RU https://pubmed.ncbi.nlm.nih.gov/1738150 DME5238 DI DME5238 DME5238 DN 3-(4-Hydroxy-phenyl)-2,3-diphenyl-acrylonitrile DME5238 MI TT8QL1J DME5238 MN Protein kinase C theta (PRKCQ) DME5238 MT DTT DME5238 MA Inhibitor DME5238 RN Multivariate analysis by the minimum spanning tree method of the structural determinants of diphenylethylenes and triphenylacrylonitriles implicate... J Med Chem. 1992 Feb 7;35(3):573-83. DME5238 RU https://pubmed.ncbi.nlm.nih.gov/1738150 DME5238 DI DME5238 DME5238 DN 3-(4-Hydroxy-phenyl)-2,3-diphenyl-acrylonitrile DME5238 MI TTUWGRA DME5238 MN Protein kinase C zeta (PRKCZ) DME5238 MT DTT DME5238 MA Inhibitor DME5238 RN Multivariate analysis by the minimum spanning tree method of the structural determinants of diphenylethylenes and triphenylacrylonitriles implicate... J Med Chem. 1992 Feb 7;35(3):573-83. DME5238 RU https://pubmed.ncbi.nlm.nih.gov/1738150 DMN01PI DI DMN01PI DMN01PI DN 3-(4-Hydroxy-phenyl)-4H-chromen-7-ol DMN01PI MI TTOM3J0 DMN01PI MN Estrogen receptor beta (ESR2) DMN01PI MT DTT DMN01PI MA Inhibitor DMN01PI RN Structure-based virtual screening for plant-based ERbeta-selective ligands as potential preventative therapy against age-related neurodegenerative ... J Med Chem. 2005 May 19;48(10):3463-6. DMN01PI RU https://pubmed.ncbi.nlm.nih.gov/15887952 DM3XOVL DI DM3XOVL DM3XOVL DN 3-(4-hydroxyphenyl)-6-methyl-2H-chromen-2-one DM3XOVL MI TTGP7BY DM3XOVL MN Monoamine oxidase type B (MAO-B) DM3XOVL MT DTT DM3XOVL MA Inhibitor DM3XOVL RN Synthesis and evaluation of 6-methyl-3-phenylcoumarins as potent and selective MAO-B inhibitors. Bioorg Med Chem Lett. 2009 Sep 1;19(17):5053-5. DM3XOVL RU https://pubmed.ncbi.nlm.nih.gov/19628387 DMS5N6Y DI DMS5N6Y DMS5N6Y DN 3-(4-Hydroxyphenyl)-7-isobutoxychromen-4-one DMS5N6Y MI TTZAYWL DMS5N6Y MN Estrogen receptor (ESR) DMS5N6Y MT DTT DMS5N6Y MA Inhibitor DMS5N6Y RN Effects of 7-O substitutions on estrogenic and anti-estrogenic activities of daidzein analogues in MCF-7 breast cancer cells. J Med Chem. 2010 Aug 26;53(16):6153-63. DMS5N6Y RU https://pubmed.ncbi.nlm.nih.gov/20669983 DMH75AO DI DMH75AO DMH75AO DN 3-(4-Hydroxyphenyl)-7-isopropoxychromen-4-one DMH75AO MI TTZAYWL DMH75AO MN Estrogen receptor (ESR) DMH75AO MT DTT DMH75AO MA Inhibitor DMH75AO RN Effects of 7-O substitutions on estrogenic and anti-estrogenic activities of daidzein analogues in MCF-7 breast cancer cells. J Med Chem. 2010 Aug 26;53(16):6153-63. DMH75AO RU https://pubmed.ncbi.nlm.nih.gov/20669983 DMXZ9T6 DI DMXZ9T6 DMXZ9T6 DN 3-(4-Hydroxy-phenyl)-benzo[d]isoxazol-5-ol DMXZ9T6 MI TTZAYWL DMXZ9T6 MN Estrogen receptor (ESR) DMXZ9T6 MT DTT DMXZ9T6 MA Inhibitor DMXZ9T6 RN Design and synthesis of aryl diphenolic azoles as potent and selective estrogen receptor-beta ligands. J Med Chem. 2004 Oct 7;47(21):5021-40. DMXZ9T6 RU https://pubmed.ncbi.nlm.nih.gov/15456246 DMXZ9T6 DI DMXZ9T6 DMXZ9T6 DN 3-(4-Hydroxy-phenyl)-benzo[d]isoxazol-5-ol DMXZ9T6 MI TTOM3J0 DMXZ9T6 MN Estrogen receptor beta (ESR2) DMXZ9T6 MT DTT DMXZ9T6 MA Inhibitor DMXZ9T6 RN Design and synthesis of aryl diphenolic azoles as potent and selective estrogen receptor-beta ligands. J Med Chem. 2004 Oct 7;47(21):5021-40. DMXZ9T6 RU https://pubmed.ncbi.nlm.nih.gov/15456246 DMYLDFG DI DMYLDFG DMYLDFG DN 3-(4-Hydroxy-phenyl)-benzo[d]isoxazol-6-ol DMYLDFG MI TTZAYWL DMYLDFG MN Estrogen receptor (ESR) DMYLDFG MT DTT DMYLDFG MA Inhibitor DMYLDFG RN Design and synthesis of aryl diphenolic azoles as potent and selective estrogen receptor-beta ligands. J Med Chem. 2004 Oct 7;47(21):5021-40. DMYLDFG RU https://pubmed.ncbi.nlm.nih.gov/15456246 DMYLDFG DI DMYLDFG DMYLDFG DN 3-(4-Hydroxy-phenyl)-benzo[d]isoxazol-6-ol DMYLDFG MI TTOM3J0 DMYLDFG MN Estrogen receptor beta (ESR2) DMYLDFG MT DTT DMYLDFG MA Inhibitor DMYLDFG RN Design and synthesis of aryl diphenolic azoles as potent and selective estrogen receptor-beta ligands. J Med Chem. 2004 Oct 7;47(21):5021-40. DMYLDFG RU https://pubmed.ncbi.nlm.nih.gov/15456246 DM18MOH DI DM18MOH DM18MOH DN 3-(4'-Hydroxyphenyl)diazenylbenzenesulfonamide DM18MOH MI TTANPDJ DM18MOH MN Carbonic anhydrase II (CA-II) DM18MOH MT DTT DM18MOH MA Inhibitor DM18MOH RN Carbonic anhydrase inhibitors. Inhibition of the Rv1284 and Rv3273 beta-carbonic anhydrases from Mycobacterium tuberculosis with diazenylbenzenesul... Bioorg Med Chem Lett. 2009 Sep 1;19(17):4929-32. DM18MOH RU https://pubmed.ncbi.nlm.nih.gov/19651511 DM18MOH DI DM18MOH DM18MOH DN 3-(4'-Hydroxyphenyl)diazenylbenzenesulfonamide DM18MOH MI TT2LVK8 DM18MOH MN Carbonic anhydrase IX (CA-IX) DM18MOH MT DTT DM18MOH MA Inhibitor DM18MOH RN Carbonic anhydrase inhibitors. Diazenylbenzenesulfonamides are potent and selective inhibitors of the tumor-associated isozymes IX and XII over the... Bioorg Med Chem. 2009 Oct 15;17(20):7093-9. DM18MOH RU https://pubmed.ncbi.nlm.nih.gov/19773173 DM18MOH DI DM18MOH DM18MOH DN 3-(4'-Hydroxyphenyl)diazenylbenzenesulfonamide DM18MOH MI TTSYM0R DM18MOH MN Carbonic anhydrase XII (CA-XII) DM18MOH MT DTT DM18MOH MA Inhibitor DM18MOH RN Carbonic anhydrase inhibitors. Diazenylbenzenesulfonamides are potent and selective inhibitors of the tumor-associated isozymes IX and XII over the... Bioorg Med Chem. 2009 Oct 15;17(20):7093-9. DM18MOH RU https://pubmed.ncbi.nlm.nih.gov/19773173 DMSR2O3 DI DMSR2O3 DMSR2O3 DN 3-(4-Methanesulfonyl-phenyl)-1-phenyl-propynone DMSR2O3 MI TT8NGED DMSR2O3 MN Prostaglandin G/H synthase 1 (COX-1) DMSR2O3 MT DTT DMSR2O3 MA Inhibitor DMSR2O3 RN Synthesis and biological evaluation of 1,3-diphenylprop-2-yn-1-ones as dual inhibitors of cyclooxygenases and lipoxygenases. Bioorg Med Chem Lett. 2005 Nov 1;15(21):4842-5. DMSR2O3 RU https://pubmed.ncbi.nlm.nih.gov/16143531 DMSR2O3 DI DMSR2O3 DMSR2O3 DN 3-(4-Methanesulfonyl-phenyl)-1-phenyl-propynone DMSR2O3 MI TTVKILB DMSR2O3 MN Prostaglandin G/H synthase 2 (COX-2) DMSR2O3 MT DTT DMSR2O3 MA Inhibitor DMSR2O3 RN Synthesis and biological evaluation of 1,3-diphenylprop-2-yn-1-ones as dual inhibitors of cyclooxygenases and lipoxygenases. Bioorg Med Chem Lett. 2005 Nov 1;15(21):4842-5. DMSR2O3 RU https://pubmed.ncbi.nlm.nih.gov/16143531 DM206M1 DI DM206M1 DM206M1 DN 3-(4-Methoxy-benzenesulfonyl)-cyclohexanethiol DM206M1 MI TTMX39J DM206M1 MN Matrix metalloproteinase-1 (MMP-1) DM206M1 MT DTT DM206M1 MA Inhibitor DM206M1 RN Synthesis and identification of conformationally constrained selective MMP inhibitors. Bioorg Med Chem Lett. 1999 Jul 5;9(13):1757-60. DM206M1 RU https://pubmed.ncbi.nlm.nih.gov/10406637 DM206M1 DI DM206M1 DM206M1 DN 3-(4-Methoxy-benzenesulfonyl)-cyclohexanethiol DM206M1 MI TTHY57M DM206M1 MN Matrix metalloproteinase-13 (MMP-13) DM206M1 MT DTT DM206M1 MA Inhibitor DM206M1 RN Synthesis and identification of conformationally constrained selective MMP inhibitors. Bioorg Med Chem Lett. 1999 Jul 5;9(13):1757-60. DM206M1 RU https://pubmed.ncbi.nlm.nih.gov/10406637 DM206M1 DI DM206M1 DM206M1 DN 3-(4-Methoxy-benzenesulfonyl)-cyclohexanethiol DM206M1 MI TTGA1IV DM206M1 MN Matrix metalloproteinase-8 (MMP-8) DM206M1 MT DTT DM206M1 MA Inhibitor DM206M1 RN Synthesis and identification of conformationally constrained selective MMP inhibitors. Bioorg Med Chem Lett. 1999 Jul 5;9(13):1757-60. DM206M1 RU https://pubmed.ncbi.nlm.nih.gov/10406637 DMK79U1 DI DMK79U1 DMK79U1 DN 3-(4-Methoxy-benzenesulfonyl)-cyclopentanethiol DMK79U1 MI TTHY57M DMK79U1 MN Matrix metalloproteinase-13 (MMP-13) DMK79U1 MT DTT DMK79U1 MA Inhibitor DMK79U1 RN Synthesis and identification of conformationally constrained selective MMP inhibitors. Bioorg Med Chem Lett. 1999 Jul 5;9(13):1757-60. DMK79U1 RU https://pubmed.ncbi.nlm.nih.gov/10406637 DMRLAX8 DI DMRLAX8 DMRLAX8 DN 3-(4-Methoxy-benzenesulfonyl)-hexane-1-thiol DMRLAX8 MI TTMX39J DMRLAX8 MN Matrix metalloproteinase-1 (MMP-1) DMRLAX8 MT DTT DMRLAX8 MA Inhibitor DMRLAX8 RN Discovery of a novel series of selective MMP inhibitors: identification of the gamma-sulfone-thiols. Bioorg Med Chem Lett. 1999 Apr 5;9(7):943-8. DMRLAX8 RU https://pubmed.ncbi.nlm.nih.gov/10230616 DMRLAX8 DI DMRLAX8 DMRLAX8 DN 3-(4-Methoxy-benzenesulfonyl)-hexane-1-thiol DMRLAX8 MI TTHY57M DMRLAX8 MN Matrix metalloproteinase-13 (MMP-13) DMRLAX8 MT DTT DMRLAX8 MA Inhibitor DMRLAX8 RN Discovery of a novel series of selective MMP inhibitors: identification of the gamma-sulfone-thiols. Bioorg Med Chem Lett. 1999 Apr 5;9(7):943-8. DMRLAX8 RU https://pubmed.ncbi.nlm.nih.gov/10230616 DM854IG DI DM854IG DM854IG DN 3-(4-Methoxy-benzenesulfonyl)-pentane-1-thiol DM854IG MI TTMX39J DM854IG MN Matrix metalloproteinase-1 (MMP-1) DM854IG MT DTT DM854IG MA Inhibitor DM854IG RN Discovery of a novel series of selective MMP inhibitors: identification of the gamma-sulfone-thiols. Bioorg Med Chem Lett. 1999 Apr 5;9(7):943-8. DM854IG RU https://pubmed.ncbi.nlm.nih.gov/10230616 DM854IG DI DM854IG DM854IG DN 3-(4-Methoxy-benzenesulfonyl)-pentane-1-thiol DM854IG MI TTHY57M DM854IG MN Matrix metalloproteinase-13 (MMP-13) DM854IG MT DTT DM854IG MA Inhibitor DM854IG RN Discovery of a novel series of selective MMP inhibitors: identification of the gamma-sulfone-thiols. Bioorg Med Chem Lett. 1999 Apr 5;9(7):943-8. DM854IG RU https://pubmed.ncbi.nlm.nih.gov/10230616 DM7B1VT DI DM7B1VT DM7B1VT DN 3-(4-Methoxy-benzenesulfonyl)-propane-1-thiol DM7B1VT MI TTHY57M DM7B1VT MN Matrix metalloproteinase-13 (MMP-13) DM7B1VT MT DTT DM7B1VT MA Inhibitor DM7B1VT RN Discovery of a novel series of selective MMP inhibitors: identification of the gamma-sulfone-thiols. Bioorg Med Chem Lett. 1999 Apr 5;9(7):943-8. DM7B1VT RU https://pubmed.ncbi.nlm.nih.gov/10230616 DM7B1VT DI DM7B1VT DM7B1VT DN 3-(4-Methoxy-benzenesulfonyl)-propane-1-thiol DM7B1VT MI TTGA1IV DM7B1VT MN Matrix metalloproteinase-8 (MMP-8) DM7B1VT MT DTT DM7B1VT MA Inhibitor DM7B1VT RN Synthesis and identification of conformationally constrained selective MMP inhibitors. Bioorg Med Chem Lett. 1999 Jul 5;9(13):1757-60. DM7B1VT RU https://pubmed.ncbi.nlm.nih.gov/10406637 DMFRZGS DI DMFRZGS DMFRZGS DN 3-(4-methoxybenzyloxy)-2-phenylthiazolidin-4-one DMFRZGS MI TTW0CMT DMFRZGS MN Voltage-gated potassium channel Kv1.5 (KCNA5) DMFRZGS MT DTT DMFRZGS MA Inhibitor DMFRZGS RN Evolution of thiazolidine-based blockers of human Kv1.5 for the treatment of atrial arrhythmias. Bioorg Med Chem Lett. 2007 Jan 1;17(1):282-4. DMFRZGS RU https://pubmed.ncbi.nlm.nih.gov/17095219 DMGC7RY DI DMGC7RY DMGC7RY DN 3-(4-methoxyphenyl)-4-phenyl-1H-pyrrole-2,5-dione DMGC7RY MI TT9VGXW DMGC7RY MN Angiopoietin 1 receptor (TEK) DMGC7RY MT DTT DMGC7RY MA Inhibitor DMGC7RY RN Design, synthesis, and biological evaluation of 3,4-diarylmaleimides as angiogenesis inhibitors. J Med Chem. 2006 Feb 23;49(4):1271-81. DMGC7RY RU https://pubmed.ncbi.nlm.nih.gov/16480264 DMGC7RY DI DMGC7RY DMGC7RY DN 3-(4-methoxyphenyl)-4-phenyl-1H-pyrrole-2,5-dione DMGC7RY MI TTH6V3D DMGC7RY MN Cyclin-dependent kinase 1 (CDK1) DMGC7RY MT DTT DMGC7RY MA Inhibitor DMGC7RY RN Design, synthesis, and biological evaluation of 3,4-diarylmaleimides as angiogenesis inhibitors. J Med Chem. 2006 Feb 23;49(4):1271-81. DMGC7RY RU https://pubmed.ncbi.nlm.nih.gov/16480264 DMGC7RY DI DMGC7RY DMGC7RY DN 3-(4-methoxyphenyl)-4-phenyl-1H-pyrrole-2,5-dione DMGC7RY MI TT7HF4W DMGC7RY MN Cyclin-dependent kinase 2 (CDK2) DMGC7RY MT DTT DMGC7RY MA Inhibitor DMGC7RY RN Design, synthesis, and biological evaluation of 3,4-diarylmaleimides as angiogenesis inhibitors. J Med Chem. 2006 Feb 23;49(4):1271-81. DMGC7RY RU https://pubmed.ncbi.nlm.nih.gov/16480264 DMGC7RY DI DMGC7RY DMGC7RY DN 3-(4-methoxyphenyl)-4-phenyl-1H-pyrrole-2,5-dione DMGC7RY MI TT0PG8F DMGC7RY MN Cyclin-dependent kinase 4 (CDK4) DMGC7RY MT DTT DMGC7RY MA Inhibitor DMGC7RY RN Design, synthesis, and biological evaluation of 3,4-diarylmaleimides as angiogenesis inhibitors. J Med Chem. 2006 Feb 23;49(4):1271-81. DMGC7RY RU https://pubmed.ncbi.nlm.nih.gov/16480264 DMGC7RY DI DMGC7RY DMGC7RY DN 3-(4-methoxyphenyl)-4-phenyl-1H-pyrrole-2,5-dione DMGC7RY MI TTO0FDJ DMGC7RY MN Cyclin-dependent kinase 6 (CDK6) DMGC7RY MT DTT DMGC7RY MA Inhibitor DMGC7RY RN Design, synthesis, and biological evaluation of 3,4-diarylmaleimides as angiogenesis inhibitors. J Med Chem. 2006 Feb 23;49(4):1271-81. DMGC7RY RU https://pubmed.ncbi.nlm.nih.gov/16480264 DMGC7RY DI DMGC7RY DMGC7RY DN 3-(4-methoxyphenyl)-4-phenyl-1H-pyrrole-2,5-dione DMGC7RY MI TTGKNB4 DMGC7RY MN Epidermal growth factor receptor (EGFR) DMGC7RY MT DTT DMGC7RY MA Inhibitor DMGC7RY RN Design, synthesis, and biological evaluation of 3,4-diarylmaleimides as angiogenesis inhibitors. J Med Chem. 2006 Feb 23;49(4):1271-81. DMGC7RY RU https://pubmed.ncbi.nlm.nih.gov/16480264 DMGC7RY DI DMGC7RY DMGC7RY DN 3-(4-methoxyphenyl)-4-phenyl-1H-pyrrole-2,5-dione DMGC7RY MI TTR5TV4 DMGC7RY MN ERBB2 messenger RNA (HER2 mRNA) DMGC7RY MT DTT DMGC7RY MA Inhibitor DMGC7RY RN Design, synthesis, and biological evaluation of 3,4-diarylmaleimides as angiogenesis inhibitors. J Med Chem. 2006 Feb 23;49(4):1271-81. DMGC7RY RU https://pubmed.ncbi.nlm.nih.gov/16480264 DMGC7RY DI DMGC7RY DMGC7RY DN 3-(4-methoxyphenyl)-4-phenyl-1H-pyrrole-2,5-dione DMGC7RY MI TTFCJ7S DMGC7RY MN G1/S-specific cyclin-D1 (CCND1) DMGC7RY MT DTT DMGC7RY MA Inhibitor DMGC7RY RN Design, synthesis, and biological evaluation of 3,4-diarylmaleimides as angiogenesis inhibitors. J Med Chem. 2006 Feb 23;49(4):1271-81. DMGC7RY RU https://pubmed.ncbi.nlm.nih.gov/16480264 DMGC7RY DI DMGC7RY DMGC7RY DN 3-(4-methoxyphenyl)-4-phenyl-1H-pyrrole-2,5-dione DMGC7RY MI TTCEJ4F DMGC7RY MN G1/S-specific cyclin-E1 (CCNE1) DMGC7RY MT DTT DMGC7RY MA Inhibitor DMGC7RY RN Design, synthesis, and biological evaluation of 3,4-diarylmaleimides as angiogenesis inhibitors. J Med Chem. 2006 Feb 23;49(4):1271-81. DMGC7RY RU https://pubmed.ncbi.nlm.nih.gov/16480264 DMGC7RY DI DMGC7RY DMGC7RY DN 3-(4-methoxyphenyl)-4-phenyl-1H-pyrrole-2,5-dione DMGC7RY MI TT9P6OW DMGC7RY MN G2/mitotic-specific cyclin B1 (CCNB1) DMGC7RY MT DTT DMGC7RY MA Inhibitor DMGC7RY RN Design, synthesis, and biological evaluation of 3,4-diarylmaleimides as angiogenesis inhibitors. J Med Chem. 2006 Feb 23;49(4):1271-81. DMGC7RY RU https://pubmed.ncbi.nlm.nih.gov/16480264 DMGC7RY DI DMGC7RY DMGC7RY DN 3-(4-methoxyphenyl)-4-phenyl-1H-pyrrole-2,5-dione DMGC7RY MI TTFJ8Q1 DMGC7RY MN Protein kinase C alpha (PRKCA) DMGC7RY MT DTT DMGC7RY MA Inhibitor DMGC7RY RN Design, synthesis, and biological evaluation of 3,4-diarylmaleimides as angiogenesis inhibitors. J Med Chem. 2006 Feb 23;49(4):1271-81. DMGC7RY RU https://pubmed.ncbi.nlm.nih.gov/16480264 DMGC7RY DI DMGC7RY DMGC7RY DN 3-(4-methoxyphenyl)-4-phenyl-1H-pyrrole-2,5-dione DMGC7RY MI TTBZ7OD DMGC7RY MN Protein kinase C epsilon (PRKCE) DMGC7RY MT DTT DMGC7RY MA Inhibitor DMGC7RY RN Design, synthesis, and biological evaluation of 3,4-diarylmaleimides as angiogenesis inhibitors. J Med Chem. 2006 Feb 23;49(4):1271-81. DMGC7RY RU https://pubmed.ncbi.nlm.nih.gov/16480264 DMGC7RY DI DMGC7RY DMGC7RY DN 3-(4-methoxyphenyl)-4-phenyl-1H-pyrrole-2,5-dione DMGC7RY MI TTRFOXJ DMGC7RY MN Protein kinase C gamma (PRKCG) DMGC7RY MT DTT DMGC7RY MA Inhibitor DMGC7RY RN Design, synthesis, and biological evaluation of 3,4-diarylmaleimides as angiogenesis inhibitors. J Med Chem. 2006 Feb 23;49(4):1271-81. DMGC7RY RU https://pubmed.ncbi.nlm.nih.gov/16480264 DMGC7RY DI DMGC7RY DMGC7RY DN 3-(4-methoxyphenyl)-4-phenyl-1H-pyrrole-2,5-dione DMGC7RY MI TTUTJGQ DMGC7RY MN Vascular endothelial growth factor receptor 2 (KDR) DMGC7RY MT DTT DMGC7RY MA Inhibitor DMGC7RY RN Design, synthesis, and biological evaluation of 3,4-diarylmaleimides as angiogenesis inhibitors. J Med Chem. 2006 Feb 23;49(4):1271-81. DMGC7RY RU https://pubmed.ncbi.nlm.nih.gov/16480264 DMXKJOC DI DMXKJOC DMXKJOC DN 3-(4-methoxyphenyl)-6-methyl-2H-chromen-2-one DMXKJOC MI TTGP7BY DMXKJOC MN Monoamine oxidase type B (MAO-B) DMXKJOC MT DTT DMXKJOC MA Inhibitor DMXKJOC RN Synthesis and evaluation of 6-methyl-3-phenylcoumarins as potent and selective MAO-B inhibitors. Bioorg Med Chem Lett. 2009 Sep 1;19(17):5053-5. DMXKJOC RU https://pubmed.ncbi.nlm.nih.gov/19628387 DM7WPQC DI DM7WPQC DM7WPQC DN 3-(4-methoxyphenyl)quinoxaline-5-carboxamide DM7WPQC MI TTVDSZ0 DM7WPQC MN Poly [ADP-ribose] polymerase 1 (PARP1) DM7WPQC MT DTT DM7WPQC MA Inhibitor DM7WPQC RN Design, synthesis, and cytoprotective effect of 2-aminothiazole analogues as potent poly(ADP-ribose) polymerase-1 inhibitors. J Med Chem. 2009 Feb 12;52(3):718-25. DM7WPQC RU https://pubmed.ncbi.nlm.nih.gov/19125579 DMDR20P DI DMDR20P DMDR20P DN 3-(4-methyl-3,4-dihydronaphthalen-2-yl)pyridine DMDR20P MI TTSZLWK DMDR20P MN Aromatase (CYP19A1) DMDR20P MT DTT DMDR20P MA Inhibitor DMDR20P RN Synthesis and evaluation of heteroaryl-substituted dihydronaphthalenes and indenes: potent and selective inhibitors of aldosterone synthase (CYP11B... J Med Chem. 2006 Apr 6;49(7):2222-31. DMDR20P RU https://pubmed.ncbi.nlm.nih.gov/16570918 DMDR20P DI DMDR20P DMDR20P DN 3-(4-methyl-3,4-dihydronaphthalen-2-yl)pyridine DMDR20P MI TTIQUX7 DMDR20P MN Steroid 11-beta-hydroxylase (CYP11B1) DMDR20P MT DTT DMDR20P MA Inhibitor DMDR20P RN Synthesis and evaluation of heteroaryl-substituted dihydronaphthalenes and indenes: potent and selective inhibitors of aldosterone synthase (CYP11B... J Med Chem. 2006 Apr 6;49(7):2222-31. DMDR20P RU https://pubmed.ncbi.nlm.nih.gov/16570918 DM0HYDZ DI DM0HYDZ DM0HYDZ DN 3-(4-Methyl-piperidin-1-ylmethyl)-1H-indole DM0HYDZ MI TTEX248 DM0HYDZ MN Dopamine D2 receptor (D2R) DM0HYDZ MT DTT DM0HYDZ MA Inhibitor DM0HYDZ RN 3-((4-(4-Chlorophenyl)piperazin-1-yl)-methyl)-1H-pyrrolo-2,3-b-pyridine: an antagonist with high affinity and selectivity for the human dopamine D4... J Med Chem. 1996 May 10;39(10):1941-2. DM0HYDZ RU https://pubmed.ncbi.nlm.nih.gov/8642550 DM0HYDZ DI DM0HYDZ DM0HYDZ DN 3-(4-Methyl-piperidin-1-ylmethyl)-1H-indole DM0HYDZ MI TT4C8EA DM0HYDZ MN Dopamine D3 receptor (D3R) DM0HYDZ MT DTT DM0HYDZ MA Inhibitor DM0HYDZ RN 3-((4-(4-Chlorophenyl)piperazin-1-yl)-methyl)-1H-pyrrolo-2,3-b-pyridine: an antagonist with high affinity and selectivity for the human dopamine D4... J Med Chem. 1996 May 10;39(10):1941-2. DM0HYDZ RU https://pubmed.ncbi.nlm.nih.gov/8642550 DM0HYDZ DI DM0HYDZ DM0HYDZ DN 3-(4-Methyl-piperidin-1-ylmethyl)-1H-indole DM0HYDZ MI TTE0A2F DM0HYDZ MN Dopamine D4 receptor (D4R) DM0HYDZ MT DTT DM0HYDZ MA Inhibitor DM0HYDZ RN 3-((4-(4-Chlorophenyl)piperazin-1-yl)-methyl)-1H-pyrrolo-2,3-b-pyridine: an antagonist with high affinity and selectivity for the human dopamine D4... J Med Chem. 1996 May 10;39(10):1941-2. DM0HYDZ RU https://pubmed.ncbi.nlm.nih.gov/8642550 DM54MDH DI DM54MDH DM54MDH DN 3-(4-morpholinothieno[3,2-d]pyrimidin-2-yl)phenol DM54MDH MI TT9H4P3 DM54MDH MN PI3K p110 beta messenger RNA (PIK3CB mRNA) DM54MDH MT DTT DM54MDH MA Inhibitor DM54MDH RN Synthesis and biological evaluation of sulfonylhydrazone-substituted imidazo[1,2-a]pyridines as novel PI3 kinase p110alpha inhibitors. Bioorg Med Chem. 2007 Sep 1;15(17):5837-44. DM54MDH RU https://pubmed.ncbi.nlm.nih.gov/17601739 DM54MDH DI DM54MDH DM54MDH DN 3-(4-morpholinothieno[3,2-d]pyrimidin-2-yl)phenol DM54MDH MI TTHBTOP DM54MDH MN PI3-kinase gamma (PIK3CG) DM54MDH MT DTT DM54MDH MA Inhibitor DM54MDH RN Synthesis and biological evaluation of sulfonylhydrazone-substituted imidazo[1,2-a]pyridines as novel PI3 kinase p110alpha inhibitors. Bioorg Med Chem. 2007 Sep 1;15(17):5837-44. DM54MDH RU https://pubmed.ncbi.nlm.nih.gov/17601739 DMIBAM2 DI DMIBAM2 DMIBAM2 DN 3-(4-o-Tolylpiperazine-1-carbonyl)coumarin DMIBAM2 MI TT1RS9F DMIBAM2 MN Acetylcholinesterase (AChE) DMIBAM2 MT DTT DMIBAM2 MA Inhibitor DMIBAM2 RN Design, synthesis, and acetylcholinesterase inhibitory activity of novel coumarin analogues. Bioorg Med Chem. 2008 Sep 1;16(17):8011-21. DMIBAM2 RU https://pubmed.ncbi.nlm.nih.gov/18701305 DMBKDZ3 DI DMBKDZ3 DMBKDZ3 DN 3-(4-Phenoxy-benzenesulfonyl)-cyclohexanethiol DMBKDZ3 MI TTMX39J DMBKDZ3 MN Matrix metalloproteinase-1 (MMP-1) DMBKDZ3 MT DTT DMBKDZ3 MA Inhibitor DMBKDZ3 RN Synthesis and identification of conformationally constrained selective MMP inhibitors. Bioorg Med Chem Lett. 1999 Jul 5;9(13):1757-60. DMBKDZ3 RU https://pubmed.ncbi.nlm.nih.gov/10406637 DMBKDZ3 DI DMBKDZ3 DMBKDZ3 DN 3-(4-Phenoxy-benzenesulfonyl)-cyclohexanethiol DMBKDZ3 MI TTHY57M DMBKDZ3 MN Matrix metalloproteinase-13 (MMP-13) DMBKDZ3 MT DTT DMBKDZ3 MA Inhibitor DMBKDZ3 RN Synthesis and identification of conformationally constrained selective MMP inhibitors. Bioorg Med Chem Lett. 1999 Jul 5;9(13):1757-60. DMBKDZ3 RU https://pubmed.ncbi.nlm.nih.gov/10406637 DMBKDZ3 DI DMBKDZ3 DMBKDZ3 DN 3-(4-Phenoxy-benzenesulfonyl)-cyclohexanethiol DMBKDZ3 MI TTGA1IV DMBKDZ3 MN Matrix metalloproteinase-8 (MMP-8) DMBKDZ3 MT DTT DMBKDZ3 MA Inhibitor DMBKDZ3 RN Synthesis and identification of conformationally constrained selective MMP inhibitors. Bioorg Med Chem Lett. 1999 Jul 5;9(13):1757-60. DMBKDZ3 RU https://pubmed.ncbi.nlm.nih.gov/10406637 DM2HBGL DI DM2HBGL DM2HBGL DN 3-(4-Phenoxy-benzenesulfonyl)-propane-1-thiol DM2HBGL MI TTMX39J DM2HBGL MN Matrix metalloproteinase-1 (MMP-1) DM2HBGL MT DTT DM2HBGL MA Inhibitor DM2HBGL RN Discovery of a novel series of selective MMP inhibitors: identification of the gamma-sulfone-thiols. Bioorg Med Chem Lett. 1999 Apr 5;9(7):943-8. DM2HBGL RU https://pubmed.ncbi.nlm.nih.gov/10230616 DM2HBGL DI DM2HBGL DM2HBGL DN 3-(4-Phenoxy-benzenesulfonyl)-propane-1-thiol DM2HBGL MI TTHY57M DM2HBGL MN Matrix metalloproteinase-13 (MMP-13) DM2HBGL MT DTT DM2HBGL MA Inhibitor DM2HBGL RN Discovery of a novel series of selective MMP inhibitors: identification of the gamma-sulfone-thiols. Bioorg Med Chem Lett. 1999 Apr 5;9(7):943-8. DM2HBGL RU https://pubmed.ncbi.nlm.nih.gov/10230616 DM2HBGL DI DM2HBGL DM2HBGL DN 3-(4-Phenoxy-benzenesulfonyl)-propane-1-thiol DM2HBGL MI TTGA1IV DM2HBGL MN Matrix metalloproteinase-8 (MMP-8) DM2HBGL MT DTT DM2HBGL MA Inhibitor DM2HBGL RN Synthesis and identification of conformationally constrained selective MMP inhibitors. Bioorg Med Chem Lett. 1999 Jul 5;9(13):1757-60. DM2HBGL RU https://pubmed.ncbi.nlm.nih.gov/10406637 DMO6LID DI DMO6LID DMO6LID DN 3-(4-Phenoxy-phenyl)-1H-pyrazole DMO6LID MI TT84DRB DMO6LID MN Voltage-gated sodium channel alpha Nav1.4 (SCN4A) DMO6LID MT DTT DMO6LID MA Inhibitor DMO6LID RN 3-(4-phenoxyphenyl)pyrazoles: a novel class of sodium channel blockers. J Med Chem. 2004 Mar 11;47(6):1547-52. DMO6LID RU https://pubmed.ncbi.nlm.nih.gov/14998340 DMSZ1VC DI DMSZ1VC DMSZ1VC DN 3-(4-phenyl-2,4'-bipyridin-6-yl)phenol DMSZ1VC MI TTGTQHC DMSZ1VC MN DNA topoisomerase I (TOP1) DMSZ1VC MT DTT DMSZ1VC MA Inhibitor DMSZ1VC RN Synthesis, topoisomerase I and II inhibitory activity, cytotoxicity, and structure-activity relationship study of hydroxylated 2,4-diphenyl-6-aryl ... Bioorg Med Chem. 2010 May 1;18(9):3066-77. DMSZ1VC RU https://pubmed.ncbi.nlm.nih.gov/20392646 DM0OF64 DI DM0OF64 DM0OF64 DN 3-(4-phenyl-6-(thiophen-2-yl)pyridin-2-yl)-phenol DM0OF64 MI TTGTQHC DM0OF64 MN DNA topoisomerase I (TOP1) DM0OF64 MT DTT DM0OF64 MA Inhibitor DM0OF64 RN Synthesis, topoisomerase I and II inhibitory activity, cytotoxicity, and structure-activity relationship study of hydroxylated 2,4-diphenyl-6-aryl ... Bioorg Med Chem. 2010 May 1;18(9):3066-77. DM0OF64 RU https://pubmed.ncbi.nlm.nih.gov/20392646 DM0OF64 DI DM0OF64 DM0OF64 DN 3-(4-phenyl-6-(thiophen-2-yl)pyridin-2-yl)-phenol DM0OF64 MI TT0IHXV DM0OF64 MN DNA topoisomerase II (TOP2) DM0OF64 MT DTT DM0OF64 MA Inhibitor DM0OF64 RN Synthesis, topoisomerase I and II inhibitory activity, cytotoxicity, and structure-activity relationship study of hydroxylated 2,4-diphenyl-6-aryl ... Bioorg Med Chem. 2010 May 1;18(9):3066-77. DM0OF64 RU https://pubmed.ncbi.nlm.nih.gov/20392646 DMTR8SZ DI DMTR8SZ DMTR8SZ DN 3-(4-phenyl-6-(thiophen-3-yl)pyridin-2-yl)-phenol DMTR8SZ MI TTGTQHC DMTR8SZ MN DNA topoisomerase I (TOP1) DMTR8SZ MT DTT DMTR8SZ MA Inhibitor DMTR8SZ RN Synthesis, topoisomerase I and II inhibitory activity, cytotoxicity, and structure-activity relationship study of hydroxylated 2,4-diphenyl-6-aryl ... Bioorg Med Chem. 2010 May 1;18(9):3066-77. DMTR8SZ RU https://pubmed.ncbi.nlm.nih.gov/20392646 DMTR8SZ DI DMTR8SZ DMTR8SZ DN 3-(4-phenyl-6-(thiophen-3-yl)pyridin-2-yl)-phenol DMTR8SZ MI TT0IHXV DMTR8SZ MN DNA topoisomerase II (TOP2) DMTR8SZ MT DTT DMTR8SZ MA Inhibitor DMTR8SZ RN Synthesis, topoisomerase I and II inhibitory activity, cytotoxicity, and structure-activity relationship study of hydroxylated 2,4-diphenyl-6-aryl ... Bioorg Med Chem. 2010 May 1;18(9):3066-77. DMTR8SZ RU https://pubmed.ncbi.nlm.nih.gov/20392646 DMXL0J5 DI DMXL0J5 DMXL0J5 DN 3-(4-Phenylethynylbenzoyl)nonanoic acid DMXL0J5 MI TTXZ0KQ DMXL0J5 MN Matrix metalloproteinase-12 (MMP-12) DMXL0J5 MT DTT DMXL0J5 MA Inhibitor DMXL0J5 RN Selective inhibition of matrix metalloproteinase isozymes and in vivo protection against emphysema by substituted gamma-keto carboxylic acids. J Med Chem. 2006 Jan 26;49(2):456-8. DMXL0J5 RU https://pubmed.ncbi.nlm.nih.gov/16420030 DMXL0J5 DI DMXL0J5 DMXL0J5 DN 3-(4-Phenylethynylbenzoyl)nonanoic acid DMXL0J5 MI TTLM12X DMXL0J5 MN Matrix metalloproteinase-2 (MMP-2) DMXL0J5 MT DTT DMXL0J5 MA Inhibitor DMXL0J5 RN Selective inhibition of matrix metalloproteinase isozymes and in vivo protection against emphysema by substituted gamma-keto carboxylic acids. J Med Chem. 2006 Jan 26;49(2):456-8. DMXL0J5 RU https://pubmed.ncbi.nlm.nih.gov/16420030 DMXL0J5 DI DMXL0J5 DMXL0J5 DN 3-(4-Phenylethynylbenzoyl)nonanoic acid DMXL0J5 MI TT6X50U DMXL0J5 MN Matrix metalloproteinase-9 (MMP-9) DMXL0J5 MT DTT DMXL0J5 MA Inhibitor DMXL0J5 RN Selective inhibition of matrix metalloproteinase isozymes and in vivo protection against emphysema by substituted gamma-keto carboxylic acids. J Med Chem. 2006 Jan 26;49(2):456-8. DMXL0J5 RU https://pubmed.ncbi.nlm.nih.gov/16420030 DMH27E0 DI DMH27E0 DMH27E0 DN 3-(4-Phenylpiperazin-1-carbonyl)coumarin DMH27E0 MI TT1RS9F DMH27E0 MN Acetylcholinesterase (AChE) DMH27E0 MT DTT DMH27E0 MA Inhibitor DMH27E0 RN Design, synthesis, and acetylcholinesterase inhibitory activity of novel coumarin analogues. Bioorg Med Chem. 2008 Sep 1;16(17):8011-21. DMH27E0 RU https://pubmed.ncbi.nlm.nih.gov/18701305 DM17SNR DI DM17SNR DM17SNR DN 3-(4-Phenyl-piperazin-1-ylmethyl)-1H-indole DM17SNR MI TTEX248 DM17SNR MN Dopamine D2 receptor (D2R) DM17SNR MT DTT DM17SNR MA Inhibitor DM17SNR RN 3-((4-(4-Chlorophenyl)piperazin-1-yl)-methyl)-1H-pyrrolo-2,3-b-pyridine: an antagonist with high affinity and selectivity for the human dopamine D4... J Med Chem. 1996 May 10;39(10):1941-2. DM17SNR RU https://pubmed.ncbi.nlm.nih.gov/8642550 DM17SNR DI DM17SNR DM17SNR DN 3-(4-Phenyl-piperazin-1-ylmethyl)-1H-indole DM17SNR MI TT4C8EA DM17SNR MN Dopamine D3 receptor (D3R) DM17SNR MT DTT DM17SNR MA Inhibitor DM17SNR RN 3-((4-(4-Chlorophenyl)piperazin-1-yl)-methyl)-1H-pyrrolo-2,3-b-pyridine: an antagonist with high affinity and selectivity for the human dopamine D4... J Med Chem. 1996 May 10;39(10):1941-2. DM17SNR RU https://pubmed.ncbi.nlm.nih.gov/8642550 DM17SNR DI DM17SNR DM17SNR DN 3-(4-Phenyl-piperazin-1-ylmethyl)-1H-indole DM17SNR MI TTE0A2F DM17SNR MN Dopamine D4 receptor (D4R) DM17SNR MT DTT DM17SNR MA Inhibitor DM17SNR RN 3-((4-(4-Chlorophenyl)piperazin-1-yl)-methyl)-1H-pyrrolo-2,3-b-pyridine: an antagonist with high affinity and selectivity for the human dopamine D4... J Med Chem. 1996 May 10;39(10):1941-2. DM17SNR RU https://pubmed.ncbi.nlm.nih.gov/8642550 DMM0WGI DI DMM0WGI DMM0WGI DN 3-(4-Phenyl-piperidin-1-ylmethyl)-1H-indole DMM0WGI MI TTEX248 DMM0WGI MN Dopamine D2 receptor (D2R) DMM0WGI MT DTT DMM0WGI MA Inhibitor DMM0WGI RN 3-((4-(4-Chlorophenyl)piperazin-1-yl)-methyl)-1H-pyrrolo-2,3-b-pyridine: an antagonist with high affinity and selectivity for the human dopamine D4... J Med Chem. 1996 May 10;39(10):1941-2. DMM0WGI RU https://pubmed.ncbi.nlm.nih.gov/8642550 DMM0WGI DI DMM0WGI DMM0WGI DN 3-(4-Phenyl-piperidin-1-ylmethyl)-1H-indole DMM0WGI MI TT4C8EA DMM0WGI MN Dopamine D3 receptor (D3R) DMM0WGI MT DTT DMM0WGI MA Inhibitor DMM0WGI RN 3-((4-(4-Chlorophenyl)piperazin-1-yl)-methyl)-1H-pyrrolo-2,3-b-pyridine: an antagonist with high affinity and selectivity for the human dopamine D4... J Med Chem. 1996 May 10;39(10):1941-2. DMM0WGI RU https://pubmed.ncbi.nlm.nih.gov/8642550 DMM0WGI DI DMM0WGI DMM0WGI DN 3-(4-Phenyl-piperidin-1-ylmethyl)-1H-indole DMM0WGI MI TTE0A2F DMM0WGI MN Dopamine D4 receptor (D4R) DMM0WGI MT DTT DMM0WGI MA Inhibitor DMM0WGI RN 3-((4-(4-Chlorophenyl)piperazin-1-yl)-methyl)-1H-pyrrolo-2,3-b-pyridine: an antagonist with high affinity and selectivity for the human dopamine D4... J Med Chem. 1996 May 10;39(10):1941-2. DMM0WGI RU https://pubmed.ncbi.nlm.nih.gov/8642550 DMDYVA7 DI DMDYVA7 DMDYVA7 DN 3-(4-Pyridin-2-yl-imidazol-1-yl)-benzonitrile DMDYVA7 MI TTHS256 DMDYVA7 MN Metabotropic glutamate receptor 5 (mGluR5) DMDYVA7 MT DTT DMDYVA7 MA Inhibitor DMDYVA7 RN Discovery of novel heteroarylazoles that are metabotropic glutamate subtype 5 receptor antagonists with anxiolytic activity. J Med Chem. 2004 Sep 9;47(19):4645-8. Letter DMDYVA7 RU https://pubmed.ncbi.nlm.nih.gov/15341479 DMTD16H DI DMTD16H DMTD16H DN 3-(4-Pyridin-2-yl-pyrazol-1-yl)-benzonitrile DMTD16H MI TTHS256 DMTD16H MN Metabotropic glutamate receptor 5 (mGluR5) DMTD16H MT DTT DMTD16H MA Inhibitor DMTD16H RN Discovery of novel heteroarylazoles that are metabotropic glutamate subtype 5 receptor antagonists with anxiolytic activity. J Med Chem. 2004 Sep 9;47(19):4645-8. Letter DMTD16H RU https://pubmed.ncbi.nlm.nih.gov/15341479 DMBDW8P DI DMBDW8P DMBDW8P DN 3-(4-sulfamoylphenyl)propanoic acid DMBDW8P MI TTUNARX DMBDW8P MN Carbonic anhydrase (CA) DMBDW8P MT DTT DMBDW8P MA Inhibitor DMBDW8P RN Carbonic anhydrase inhibitors. Inhibition and homology modeling studies of the fungal beta-carbonic anhydrase from Candida albicans with sulfonamides. Bioorg Med Chem. 2009 Jul 1;17(13):4503-9. DMBDW8P RU https://pubmed.ncbi.nlm.nih.gov/19450983 DMBDW8P DI DMBDW8P DMBDW8P DN 3-(4-sulfamoylphenyl)propanoic acid DMBDW8P MI TTHQPL7 DMBDW8P MN Carbonic anhydrase I (CA-I) DMBDW8P MT DTT DMBDW8P MA Inhibitor DMBDW8P RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DMBDW8P RU https://pubmed.ncbi.nlm.nih.gov/10592235 DMBDW8P DI DMBDW8P DMBDW8P DN 3-(4-sulfamoylphenyl)propanoic acid DMBDW8P MI TTANPDJ DMBDW8P MN Carbonic anhydrase II (CA-II) DMBDW8P MT DTT DMBDW8P MA Inhibitor DMBDW8P RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DMBDW8P RU https://pubmed.ncbi.nlm.nih.gov/10592235 DMZB804 DI DMZB804 DMZB804 DN 3-(4-Trifluoromethylphenyl)-2-nortropene DMZB804 MI TTVBI8W DMZB804 MN Dopamine transporter (DAT) DMZB804 MT DTT DMZB804 MA Inhibitor DMZB804 RN Synthesis and monoamine transporter affinity of 3alpha-arylmethoxy-3beta-arylnortropanes. Bioorg Med Chem Lett. 2009 Dec 15;19(24):6865-8. DMZB804 RU https://pubmed.ncbi.nlm.nih.gov/19896846 DMZB804 DI DMZB804 DMZB804 DN 3-(4-Trifluoromethylphenyl)-2-nortropene DMZB804 MI TT3ROYC DMZB804 MN Serotonin transporter (SERT) DMZB804 MT DTT DMZB804 MA Inhibitor DMZB804 RN Synthesis and monoamine transporter affinity of 3alpha-arylmethoxy-3beta-arylnortropanes. Bioorg Med Chem Lett. 2009 Dec 15;19(24):6865-8. DMZB804 RU https://pubmed.ncbi.nlm.nih.gov/19896846 DM6S28U DI DM6S28U DM6S28U DN 3-(5-((methylthio)methyl)furan-2-yl)pyridine DM6S28U MI TTXV4FI DM6S28U MN Albendazole monooxygenase (CYP3A4) DM6S28U MT DTT DM6S28U MA Inhibitor DM6S28U RN Synthetic inhibitors of cytochrome P-450 2A6: inhibitory activity, difference spectra, mechanism of inhibition, and protein cocrystallization. J Med Chem. 2006 Nov 30;49(24):6987-7001. DM6S28U RU https://pubmed.ncbi.nlm.nih.gov/17125252 DMTVYLM DI DMTVYLM DMTVYLM DN 3-(5,6,7,8-Tetrahydronaphthalen-2-yl)pyridine DMTVYLM MI TTIQUX7 DMTVYLM MN Steroid 11-beta-hydroxylase (CYP11B1) DMTVYLM MT DTT DMTVYLM MA Inhibitor DMTVYLM RN In vivo active aldosterone synthase inhibitors with improved selectivity: lead optimization providing a series of pyridine substituted 3,4-dihydro-... J Med Chem. 2008 Dec 25;51(24):8077-87. DMTVYLM RU https://pubmed.ncbi.nlm.nih.gov/19049427 DMOUNPH DI DMOUNPH DMOUNPH DN 3-(5-[1,3]dithiolan-2-yl-furan-2-yl)pyridine DMOUNPH MI TTXV4FI DMOUNPH MN Albendazole monooxygenase (CYP3A4) DMOUNPH MT DTT DMOUNPH MA Inhibitor DMOUNPH RN Synthetic inhibitors of cytochrome P-450 2A6: inhibitory activity, difference spectra, mechanism of inhibition, and protein cocrystallization. J Med Chem. 2006 Nov 30;49(24):6987-7001. DMOUNPH RU https://pubmed.ncbi.nlm.nih.gov/17125252 DMUIXNS DI DMUIXNS DMUIXNS DN 3-(5-Bromo-6-methoxy-naphthalen-2-yl)-pyridine DMUIXNS MI TTSZLWK DMUIXNS MN Aromatase (CYP19A1) DMUIXNS MT DTT DMUIXNS MA Inhibitor DMUIXNS RN Heteroaryl-substituted naphthalenes and structurally modified derivatives: selective inhibitors of CYP11B2 for the treatment of congestive heart fa... J Med Chem. 2005 Oct 20;48(21):6632-42. DMUIXNS RU https://pubmed.ncbi.nlm.nih.gov/16220979 DMUIXNS DI DMUIXNS DMUIXNS DN 3-(5-Bromo-6-methoxy-naphthalen-2-yl)-pyridine DMUIXNS MI TTIQUX7 DMUIXNS MN Steroid 11-beta-hydroxylase (CYP11B1) DMUIXNS MT DTT DMUIXNS MA Inhibitor DMUIXNS RN Heteroaryl-substituted naphthalenes and structurally modified derivatives: selective inhibitors of CYP11B2 for the treatment of congestive heart fa... J Med Chem. 2005 Oct 20;48(21):6632-42. DMUIXNS RU https://pubmed.ncbi.nlm.nih.gov/16220979 DMM4HF8 DI DMM4HF8 DMM4HF8 DN 3'-(5-Chloro-2-thienyl)biphenyl-3-ol DMM4HF8 MI TTIWB6L DMM4HF8 MN Estradiol 17 beta-dehydrogenase 1 (17-beta-HSD1) DMM4HF8 MT DTT DMM4HF8 MA Inhibitor DMM4HF8 RN Novel estrone mimetics with high 17beta-HSD1 inhibitory activity. Bioorg Med Chem. 2010 May 15;18(10):3494-505. DMM4HF8 RU https://pubmed.ncbi.nlm.nih.gov/20413314 DM67DVU DI DM67DVU DM67DVU DN 3-(5-Chloro-6-methoxy-naphthalen-2-yl)-pyridine DM67DVU MI TTSZLWK DM67DVU MN Aromatase (CYP19A1) DM67DVU MT DTT DM67DVU MA Inhibitor DM67DVU RN Heteroaryl-substituted naphthalenes and structurally modified derivatives: selective inhibitors of CYP11B2 for the treatment of congestive heart fa... J Med Chem. 2005 Oct 20;48(21):6632-42. DM67DVU RU https://pubmed.ncbi.nlm.nih.gov/16220979 DM67DVU DI DM67DVU DM67DVU DN 3-(5-Chloro-6-methoxy-naphthalen-2-yl)-pyridine DM67DVU MI TTIQUX7 DM67DVU MN Steroid 11-beta-hydroxylase (CYP11B1) DM67DVU MT DTT DM67DVU MA Inhibitor DM67DVU RN Heteroaryl-substituted naphthalenes and structurally modified derivatives: selective inhibitors of CYP11B2 for the treatment of congestive heart fa... J Med Chem. 2005 Oct 20;48(21):6632-42. DM67DVU RU https://pubmed.ncbi.nlm.nih.gov/16220979 DMPRBLH DI DMPRBLH DMPRBLH DN 3-(5-Hydroxy-benzooxazol-2-yl)-benzene-1,2-diol DMPRBLH MI TTZAYWL DMPRBLH MN Estrogen receptor (ESR) DMPRBLH MT DTT DMPRBLH MA Inhibitor DMPRBLH RN Design and synthesis of aryl diphenolic azoles as potent and selective estrogen receptor-beta ligands. J Med Chem. 2004 Oct 7;47(21):5021-40. DMPRBLH RU https://pubmed.ncbi.nlm.nih.gov/15456246 DMPRBLH DI DMPRBLH DMPRBLH DN 3-(5-Hydroxy-benzooxazol-2-yl)-benzene-1,2-diol DMPRBLH MI TTOM3J0 DMPRBLH MN Estrogen receptor beta (ESR2) DMPRBLH MT DTT DMPRBLH MA Inhibitor DMPRBLH RN Design and synthesis of aryl diphenolic azoles as potent and selective estrogen receptor-beta ligands. J Med Chem. 2004 Oct 7;47(21):5021-40. DMPRBLH RU https://pubmed.ncbi.nlm.nih.gov/15456246 DMTJXOU DI DMTJXOU DMTJXOU DN 3-(5-methoxy-1H-inden-2-yl)pyridine DMTJXOU MI TTIQUX7 DMTJXOU MN Steroid 11-beta-hydroxylase (CYP11B1) DMTJXOU MT DTT DMTJXOU MA Inhibitor DMTJXOU RN Synthesis and evaluation of heteroaryl-substituted dihydronaphthalenes and indenes: potent and selective inhibitors of aldosterone synthase (CYP11B... J Med Chem. 2006 Apr 6;49(7):2222-31. DMTJXOU RU https://pubmed.ncbi.nlm.nih.gov/16570918 DMXLVG6 DI DMXLVG6 DMXLVG6 DN 3-(5-methoxy-1H-indol-3-yl)propanoic acid DMXLVG6 MI TTZMAO3 DMXLVG6 MN Peroxisome proliferator-activated receptor gamma (PPAR-gamma) DMXLVG6 MT DTT DMXLVG6 MA Inhibitor DMXLVG6 RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DMXLVG6 RU https://pubmed.ncbi.nlm.nih.gov/10592235 DM5NIE7 DI DM5NIE7 DM5NIE7 DN 3-(5-phenyl-2-thienyl)phenol DM5NIE7 MI TTIWB6L DM5NIE7 MN Estradiol 17 beta-dehydrogenase 1 (17-beta-HSD1) DM5NIE7 MT DTT DM5NIE7 MA Inhibitor DM5NIE7 RN New insights into the SAR and binding modes of bis(hydroxyphenyl)thiophenes and -benzenes: influence of additional substituents on 17beta-hydroxyst... J Med Chem. 2009 Nov 12;52(21):6724-43. DM5NIE7 RU https://pubmed.ncbi.nlm.nih.gov/19831396 DMPBLM2 DI DMPBLM2 DMPBLM2 DN 3-(5-Phenyl-oxazol-2-ylamino)-benzonitrile DMPBLM2 MI TTUTJGQ DMPBLM2 MN Vascular endothelial growth factor receptor 2 (KDR) DMPBLM2 MT DTT DMPBLM2 MA Inhibitor DMPBLM2 RN Discovery and evaluation of 2-anilino-5-aryloxazoles as a novel class of VEGFR2 kinase inhibitors. J Med Chem. 2005 Mar 10;48(5):1610-9. DMPBLM2 RU https://pubmed.ncbi.nlm.nih.gov/15743202 DMPBLM2 DI DMPBLM2 DMPBLM2 DN 3-(5-Phenyl-oxazol-2-ylamino)-benzonitrile DMPBLM2 MI TTDCBX5 DMPBLM2 MN Vascular endothelial growth factor receptor 3 (FLT-4) DMPBLM2 MT DTT DMPBLM2 MA Inhibitor DMPBLM2 RN Discovery and evaluation of 2-anilino-5-aryloxazoles as a novel class of VEGFR2 kinase inhibitors. J Med Chem. 2005 Mar 10;48(5):1610-9. DMPBLM2 RU https://pubmed.ncbi.nlm.nih.gov/15743202 DMPBLM2 DI DMPBLM2 DMPBLM2 DN 3-(5-Phenyl-oxazol-2-ylamino)-benzonitrile DMPBLM2 MI TT1VAUK DMPBLM2 MN VEGFR1 messenger RNA (VEGFR1 mRNA) DMPBLM2 MT DTT DMPBLM2 MA Inhibitor DMPBLM2 RN Discovery and evaluation of 2-anilino-5-aryloxazoles as a novel class of VEGFR2 kinase inhibitors. J Med Chem. 2005 Mar 10;48(5):1610-9. DMPBLM2 RU https://pubmed.ncbi.nlm.nih.gov/15743202 DMM1CKZ DI DMM1CKZ DMM1CKZ DN 3-(5-Pyridin-2-yl-tetrazol-2-yl)-benzonitrile DMM1CKZ MI TTHS256 DMM1CKZ MN Metabotropic glutamate receptor 5 (mGluR5) DMM1CKZ MT DTT DMM1CKZ MA Inhibitor DMM1CKZ RN Discovery of novel heteroarylazoles that are metabotropic glutamate subtype 5 receptor antagonists with anxiolytic activity. J Med Chem. 2004 Sep 9;47(19):4645-8. Letter DMM1CKZ RU https://pubmed.ncbi.nlm.nih.gov/15341479 DM9LVR5 DI DM9LVR5 DM9LVR5 DN 3-(5-Thiophen-3-yl-pyridin-3-yl)-1H-indole DM9LVR5 MI TTUTJGQ DM9LVR5 MN Vascular endothelial growth factor receptor 2 (KDR) DM9LVR5 MT DTT DM9LVR5 MA Inhibitor DM9LVR5 RN Discovery and evaluation of 3-(5-thien-3-ylpyridin-3-yl)-1H-indoles as a novel class of KDR kinase inhibitors. Bioorg Med Chem Lett. 2003 Sep 15;13(18):2973-6. DM9LVR5 RU https://pubmed.ncbi.nlm.nih.gov/12941314 DMADQCW DI DMADQCW DMADQCW DN 3-(6-(furan-2-yl)-4-phenylpyridin-2-yl)-phenol DMADQCW MI TT0IHXV DMADQCW MN DNA topoisomerase II (TOP2) DMADQCW MT DTT DMADQCW MA Inhibitor DMADQCW RN Synthesis, topoisomerase I and II inhibitory activity, cytotoxicity, and structure-activity relationship study of hydroxylated 2,4-diphenyl-6-aryl ... Bioorg Med Chem. 2010 May 1;18(9):3066-77. DMADQCW RU https://pubmed.ncbi.nlm.nih.gov/20392646 DM8WL21 DI DM8WL21 DM8WL21 DN 3-(6-(phenylamino)-9H-purin-8-yl)benzonitrile DM8WL21 MI TTRSMW9 DM8WL21 MN Glycogen synthase kinase-3 beta (GSK-3B) DM8WL21 MT DTT DM8WL21 MA Inhibitor DM8WL21 RN Novel 8-arylated purines as inhibitors of glycogen synthase kinase. Eur J Med Chem. 2010 Aug;45(8):3389-93. DM8WL21 RU https://pubmed.ncbi.nlm.nih.gov/20472330 DM4DFUS DI DM4DFUS DM4DFUS DN 3-(6,7-Dimethoxy-quinolin-4-yloxy)-phenol DM4DFUS MI TTI7421 DM4DFUS MN Platelet-derived growth factor receptor beta (PDGFRB) DM4DFUS MT DTT DM4DFUS MA Inhibitor DM4DFUS RN A novel series of 4-phenoxyquinolines: potent and highly selective inhibitors of PDGF receptor autophosphorylation, Bioorg. Med. Chem. Lett. 7(23):2935-2940 (1997). DM4DFUS RU http://www.sciencedirect.com/science/article/pii/S0960894X97101172 DMAWXV6 DI DMAWXV6 DMAWXV6 DN 3-(6,7-Dimethoxy-quinolin-4-yloxy)-phenylamine DMAWXV6 MI TTI7421 DMAWXV6 MN Platelet-derived growth factor receptor beta (PDGFRB) DMAWXV6 MT DTT DMAWXV6 MA Inhibitor DMAWXV6 RN A novel series of 4-phenoxyquinolines: potent and highly selective inhibitors of PDGF receptor autophosphorylation, Bioorg. Med. Chem. Lett. 7(23):2935-2940 (1997). DMAWXV6 RU http://www.sciencedirect.com/science/article/pii/S0960894X97101172 DMISL9R DI DMISL9R DMISL9R DN 3-(6-Amino-purin-9-yl)-4-butoxy-butan-2-ol DMISL9R MI TTLP57V DMISL9R MN Adenosine deaminase (ADA) DMISL9R MT DTT DMISL9R MA Inhibitor DMISL9R RN Adenosine deaminase inhibitors: synthesis and biological evaluation of unsaturated, aromatic, and oxo derivatives of (+)-erythro-9-(2'S-hydroxy-3'R... J Med Chem. 2000 Nov 30;43(24):4694-700. DMISL9R RU https://pubmed.ncbi.nlm.nih.gov/11101360 DMMTU78 DI DMMTU78 DMMTU78 DN 3-(6-Amino-purin-9-yl)-4-phenethyloxy-butan-2-ol DMMTU78 MI TTLP57V DMMTU78 MN Adenosine deaminase (ADA) DMMTU78 MT DTT DMMTU78 MA Inhibitor DMMTU78 RN Adenosine deaminase inhibitors: synthesis and biological evaluation of unsaturated, aromatic, and oxo derivatives of (+)-erythro-9-(2'S-hydroxy-3'R... J Med Chem. 2000 Nov 30;43(24):4694-700. DMMTU78 RU https://pubmed.ncbi.nlm.nih.gov/11101360 DMU08A4 DI DMU08A4 DMU08A4 DN 3-(6-Amino-purin-9-yl)-4-p-tolyl-butan-2-ol DMU08A4 MI TTLP57V DMU08A4 MN Adenosine deaminase (ADA) DMU08A4 MT DTT DMU08A4 MA Inhibitor DMU08A4 RN Adenosine deaminase inhibitors: synthesis and biological evaluation of unsaturated, aromatic, and oxo derivatives of (+)-erythro-9-(2'S-hydroxy-3'R... J Med Chem. 2000 Nov 30;43(24):4694-700. DMU08A4 RU https://pubmed.ncbi.nlm.nih.gov/11101360 DMHXI21 DI DMHXI21 DMHXI21 DN 3-(6-Amino-purin-9-yl)-5-m-tolyl-pentan-2-ol DMHXI21 MI TTLP57V DMHXI21 MN Adenosine deaminase (ADA) DMHXI21 MT DTT DMHXI21 MA Inhibitor DMHXI21 RN Adenosine deaminase inhibitors: synthesis and biological evaluation of unsaturated, aromatic, and oxo derivatives of (+)-erythro-9-(2'S-hydroxy-3'R... J Med Chem. 2000 Nov 30;43(24):4694-700. DMHXI21 RU https://pubmed.ncbi.nlm.nih.gov/11101360 DMYIZBK DI DMYIZBK DMYIZBK DN 3-(6-Amino-purin-9-yl)-6-o-tolyl-hexan-2-ol DMYIZBK MI TTLP57V DMYIZBK MN Adenosine deaminase (ADA) DMYIZBK MT DTT DMYIZBK MA Inhibitor DMYIZBK RN Adenosine deaminase inhibitors: synthesis and biological evaluation of unsaturated, aromatic, and oxo derivatives of (+)-erythro-9-(2'S-hydroxy-3'R... J Med Chem. 2000 Nov 30;43(24):4694-700. DMYIZBK RU https://pubmed.ncbi.nlm.nih.gov/11101360 DMZT8QX DI DMZT8QX DMZT8QX DN 3-(6-Amino-purin-9-yl)-6-phenyl-hexan-2-ol DMZT8QX MI TTLP57V DMZT8QX MN Adenosine deaminase (ADA) DMZT8QX MT DTT DMZT8QX MA Inhibitor DMZT8QX RN Adenosine deaminase inhibitors: synthesis and biological evaluation of unsaturated, aromatic, and oxo derivatives of (+)-erythro-9-(2'S-hydroxy-3'R... J Med Chem. 2000 Nov 30;43(24):4694-700. DMZT8QX RU https://pubmed.ncbi.nlm.nih.gov/11101360 DMUYELJ DI DMUYELJ DMUYELJ DN 3-(6-Amino-purin-9-yl)-7-phenyl-heptan-2-ol DMUYELJ MI TTLP57V DMUYELJ MN Adenosine deaminase (ADA) DMUYELJ MT DTT DMUYELJ MA Inhibitor DMUYELJ RN Adenosine deaminase inhibitors: synthesis and biological evaluation of unsaturated, aromatic, and oxo derivatives of (+)-erythro-9-(2'S-hydroxy-3'R... J Med Chem. 2000 Nov 30;43(24):4694-700. DMUYELJ RU https://pubmed.ncbi.nlm.nih.gov/11101360 DMAIS1D DI DMAIS1D DMAIS1D DN 3-(6-Amino-purin-9-yl)-8-phenyl-octan-2-ol DMAIS1D MI TTLP57V DMAIS1D MN Adenosine deaminase (ADA) DMAIS1D MT DTT DMAIS1D MA Inhibitor DMAIS1D RN Adenosine deaminase inhibitors: synthesis and biological evaluation of unsaturated, aromatic, and oxo derivatives of (+)-erythro-9-(2'S-hydroxy-3'R... J Med Chem. 2000 Nov 30;43(24):4694-700. DMAIS1D RU https://pubmed.ncbi.nlm.nih.gov/11101360 DM6FHWZ DI DM6FHWZ DM6FHWZ DN 3-(6-Amino-purin-9-yl)-non-5-en-2-ol DM6FHWZ MI TTLP57V DM6FHWZ MN Adenosine deaminase (ADA) DM6FHWZ MT DTT DM6FHWZ MA Inhibitor DM6FHWZ RN Adenosine deaminase inhibitors: synthesis and biological evaluation of unsaturated, aromatic, and oxo derivatives of (+)-erythro-9-(2'S-hydroxy-3'R... J Med Chem. 2000 Nov 30;43(24):4694-700. DM6FHWZ RU https://pubmed.ncbi.nlm.nih.gov/11101360 DM0YOZJ DI DM0YOZJ DM0YOZJ DN 3-(6-Amino-purin-9-yl)-non-5-yn-2-ol DM0YOZJ MI TTLP57V DM0YOZJ MN Adenosine deaminase (ADA) DM0YOZJ MT DTT DM0YOZJ MA Inhibitor DM0YOZJ RN Adenosine deaminase inhibitors: synthesis and biological evaluation of unsaturated, aromatic, and oxo derivatives of (+)-erythro-9-(2'S-hydroxy-3'R... J Med Chem. 2000 Nov 30;43(24):4694-700. DM0YOZJ RU https://pubmed.ncbi.nlm.nih.gov/11101360 DM63BI9 DI DM63BI9 DM63BI9 DN 3-(6-Bromo-naphthalen-2-yl)-pyridine DM63BI9 MI TTIQUX7 DM63BI9 MN Steroid 11-beta-hydroxylase (CYP11B1) DM63BI9 MT DTT DM63BI9 MA Inhibitor DM63BI9 RN Heteroaryl-substituted naphthalenes and structurally modified derivatives: selective inhibitors of CYP11B2 for the treatment of congestive heart fa... J Med Chem. 2005 Oct 20;48(21):6632-42. DM63BI9 RU https://pubmed.ncbi.nlm.nih.gov/16220979 DMUQ0WI DI DMUQ0WI DMUQ0WI DN 3-(6-Ethoxy-naphthalen-2-yl)-pyridine DMUQ0WI MI TTSZLWK DMUQ0WI MN Aromatase (CYP19A1) DMUQ0WI MT DTT DMUQ0WI MA Inhibitor DMUQ0WI RN Heteroaryl-substituted naphthalenes and structurally modified derivatives: selective inhibitors of CYP11B2 for the treatment of congestive heart fa... J Med Chem. 2005 Oct 20;48(21):6632-42. DMUQ0WI RU https://pubmed.ncbi.nlm.nih.gov/16220979 DMUQ0WI DI DMUQ0WI DMUQ0WI DN 3-(6-Ethoxy-naphthalen-2-yl)-pyridine DMUQ0WI MI TTIQUX7 DMUQ0WI MN Steroid 11-beta-hydroxylase (CYP11B1) DMUQ0WI MT DTT DMUQ0WI MA Inhibitor DMUQ0WI RN Heteroaryl-substituted naphthalenes and structurally modified derivatives: selective inhibitors of CYP11B2 for the treatment of congestive heart fa... J Med Chem. 2005 Oct 20;48(21):6632-42. DMUQ0WI RU https://pubmed.ncbi.nlm.nih.gov/16220979 DMUQ0WI DI DMUQ0WI DMUQ0WI DN 3-(6-Ethoxy-naphthalen-2-yl)-pyridine DMUQ0WI MI TTRA5BZ DMUQ0WI MN Steroid 17-alpha-monooxygenase (S17AH) DMUQ0WI MT DTT DMUQ0WI MA Inhibitor DMUQ0WI RN Heteroaryl-substituted naphthalenes and structurally modified derivatives: selective inhibitors of CYP11B2 for the treatment of congestive heart fa... J Med Chem. 2005 Oct 20;48(21):6632-42. DMUQ0WI RU https://pubmed.ncbi.nlm.nih.gov/16220979 DMHJ0SV DI DMHJ0SV DMHJ0SV DN 3-(6-fluoroquinazolin-4-ylamino)benzonitrile DMHJ0SV MI TTHS256 DMHJ0SV MN Metabotropic glutamate receptor 5 (mGluR5) DMHJ0SV MT DTT DMHJ0SV MA Inhibitor DMHJ0SV RN Discovery and SAR of 6-substituted-4-anilinoquinazolines as non-competitive antagonists of mGlu5. Bioorg Med Chem Lett. 2009 Dec 1;19(23):6623-6. DMHJ0SV RU https://pubmed.ncbi.nlm.nih.gov/19854049 DMTIKF7 DI DMTIKF7 DMTIKF7 DN 3-(6-hydroxy-2-naphthyl)benzoic acid DMTIKF7 MI TTIWB6L DMTIKF7 MN Estradiol 17 beta-dehydrogenase 1 (17-beta-HSD1) DMTIKF7 MT DTT DMTIKF7 MA Inhibitor DMTIKF7 RN Design, synthesis, and biological evaluation of (hydroxyphenyl)naphthalene and -quinoline derivatives: potent and selective nonsteroidal inhibitors... J Med Chem. 2008 Apr 10;51(7):2158-69. DMTIKF7 RU https://pubmed.ncbi.nlm.nih.gov/18324762 DM5H9QT DI DM5H9QT DM5H9QT DN 3-(6-Hydroxy-benzooxazol-2-yl)-benzene-1,2-diol DM5H9QT MI TTZAYWL DM5H9QT MN Estrogen receptor (ESR) DM5H9QT MT DTT DM5H9QT MA Inhibitor DM5H9QT RN Design and synthesis of aryl diphenolic azoles as potent and selective estrogen receptor-beta ligands. J Med Chem. 2004 Oct 7;47(21):5021-40. DM5H9QT RU https://pubmed.ncbi.nlm.nih.gov/15456246 DM5H9QT DI DM5H9QT DM5H9QT DN 3-(6-Hydroxy-benzooxazol-2-yl)-benzene-1,2-diol DM5H9QT MI TTOM3J0 DM5H9QT MN Estrogen receptor beta (ESR2) DM5H9QT MT DTT DM5H9QT MA Inhibitor DM5H9QT RN Design and synthesis of aryl diphenolic azoles as potent and selective estrogen receptor-beta ligands. J Med Chem. 2004 Oct 7;47(21):5021-40. DM5H9QT RU https://pubmed.ncbi.nlm.nih.gov/15456246 DMAJHXO DI DMAJHXO DMAJHXO DN 3-(6-methoxy-3,4-dihydronaphthalen-2-yl)pyridine DMAJHXO MI TTSZLWK DMAJHXO MN Aromatase (CYP19A1) DMAJHXO MT DTT DMAJHXO MA Inhibitor DMAJHXO RN Synthesis and evaluation of heteroaryl-substituted dihydronaphthalenes and indenes: potent and selective inhibitors of aldosterone synthase (CYP11B... J Med Chem. 2006 Apr 6;49(7):2222-31. DMAJHXO RU https://pubmed.ncbi.nlm.nih.gov/16570918 DMAJHXO DI DMAJHXO DMAJHXO DN 3-(6-methoxy-3,4-dihydronaphthalen-2-yl)pyridine DMAJHXO MI TTIQUX7 DMAJHXO MN Steroid 11-beta-hydroxylase (CYP11B1) DMAJHXO MT DTT DMAJHXO MA Inhibitor DMAJHXO RN Overcoming undesirable CYP1A2 inhibition of pyridylnaphthalene-type aldosterone synthase inhibitors: influence of heteroaryl derivatization on pote... J Med Chem. 2008 Aug 28;51(16):5064-74. DMAJHXO RU https://pubmed.ncbi.nlm.nih.gov/18672861 DMAJHXO DI DMAJHXO DMAJHXO DN 3-(6-methoxy-3,4-dihydronaphthalen-2-yl)pyridine DMAJHXO MI TTRA5BZ DMAJHXO MN Steroid 17-alpha-monooxygenase (S17AH) DMAJHXO MT DTT DMAJHXO MA Inhibitor DMAJHXO RN Synthesis and evaluation of heteroaryl-substituted dihydronaphthalenes and indenes: potent and selective inhibitors of aldosterone synthase (CYP11B... J Med Chem. 2006 Apr 6;49(7):2222-31. DMAJHXO RU https://pubmed.ncbi.nlm.nih.gov/16570918 DMISLV4 DI DMISLV4 DMISLV4 DN 3-(6-Methoxy-3-methylnaphthalen-2-yl)pyridine DMISLV4 MI TTIQUX7 DMISLV4 MN Steroid 11-beta-hydroxylase (CYP11B1) DMISLV4 MT DTT DMISLV4 MA Inhibitor DMISLV4 RN Overcoming undesirable CYP1A2 inhibition of pyridylnaphthalene-type aldosterone synthase inhibitors: influence of heteroaryl derivatization on pote... J Med Chem. 2008 Aug 28;51(16):5064-74. DMISLV4 RU https://pubmed.ncbi.nlm.nih.gov/18672861 DM0GXFB DI DM0GXFB DM0GXFB DN 3-(6-Methoxynaphthalen-2-yl)-4-methylpyridine DM0GXFB MI TTIQUX7 DM0GXFB MN Steroid 11-beta-hydroxylase (CYP11B1) DM0GXFB MT DTT DM0GXFB MA Inhibitor DM0GXFB RN Overcoming undesirable CYP1A2 inhibition of pyridylnaphthalene-type aldosterone synthase inhibitors: influence of heteroaryl derivatization on pote... J Med Chem. 2008 Aug 28;51(16):5064-74. DM0GXFB RU https://pubmed.ncbi.nlm.nih.gov/18672861 DM704R5 DI DM704R5 DM704R5 DN 3-(6-Methoxynaphthalen-2-yl)-5-phenylpyridine DM704R5 MI TTIQUX7 DM704R5 MN Steroid 11-beta-hydroxylase (CYP11B1) DM704R5 MT DTT DM704R5 MA Inhibitor DM704R5 RN Overcoming undesirable CYP1A2 inhibition of pyridylnaphthalene-type aldosterone synthase inhibitors: influence of heteroaryl derivatization on pote... J Med Chem. 2008 Aug 28;51(16):5064-74. DM704R5 RU https://pubmed.ncbi.nlm.nih.gov/18672861 DMN75RD DI DMN75RD DMN75RD DN 3-(6-Methoxynaphthalen-2-yl)pyridin-4-amine DMN75RD MI TTVG215 DMN75RD MN Debrisoquine 4-hydroxylase (CYP2D6) DMN75RD MT DTT DMN75RD MA Inhibitor DMN75RD RN Overcoming undesirable CYP1A2 inhibition of pyridylnaphthalene-type aldosterone synthase inhibitors: influence of heteroaryl derivatization on pote... J Med Chem. 2008 Aug 28;51(16):5064-74. DMN75RD RU https://pubmed.ncbi.nlm.nih.gov/18672861 DMN75RD DI DMN75RD DMN75RD DN 3-(6-Methoxynaphthalen-2-yl)pyridin-4-amine DMN75RD MI TTIQUX7 DMN75RD MN Steroid 11-beta-hydroxylase (CYP11B1) DMN75RD MT DTT DMN75RD MA Inhibitor DMN75RD RN Overcoming undesirable CYP1A2 inhibition of pyridylnaphthalene-type aldosterone synthase inhibitors: influence of heteroaryl derivatization on pote... J Med Chem. 2008 Aug 28;51(16):5064-74. DMN75RD RU https://pubmed.ncbi.nlm.nih.gov/18672861 DMYRJAB DI DMYRJAB DMYRJAB DN 3-(6-methoxynaphthalen-2-yl)pyridine DMYRJAB MI TTSZLWK DMYRJAB MN Aromatase (CYP19A1) DMYRJAB MT DTT DMYRJAB MA Inhibitor DMYRJAB RN In vivo active aldosterone synthase inhibitors with improved selectivity: lead optimization providing a series of pyridine substituted 3,4-dihydro-... J Med Chem. 2008 Dec 25;51(24):8077-87. DMYRJAB RU https://pubmed.ncbi.nlm.nih.gov/19049427 DMYRJAB DI DMYRJAB DMYRJAB DN 3-(6-methoxynaphthalen-2-yl)pyridine DMYRJAB MI TTIQUX7 DMYRJAB MN Steroid 11-beta-hydroxylase (CYP11B1) DMYRJAB MT DTT DMYRJAB MA Inhibitor DMYRJAB RN Novel aldosterone synthase inhibitors with extended carbocyclic skeleton by a combined ligand-based and structure-based drug design approach. J Med Chem. 2008 Oct 9;51(19):6138-49. DMYRJAB RU https://pubmed.ncbi.nlm.nih.gov/18763754 DMYRJAB DI DMYRJAB DMYRJAB DN 3-(6-methoxynaphthalen-2-yl)pyridine DMYRJAB MI TTRA5BZ DMYRJAB MN Steroid 17-alpha-monooxygenase (S17AH) DMYRJAB MT DTT DMYRJAB MA Inhibitor DMYRJAB RN In vivo active aldosterone synthase inhibitors with improved selectivity: lead optimization providing a series of pyridine substituted 3,4-dihydro-... J Med Chem. 2008 Dec 25;51(24):8077-87. DMYRJAB RU https://pubmed.ncbi.nlm.nih.gov/19049427 DMS9DPO DI DMS9DPO DMS9DPO DN 3-(6-morpholino-4-oxo-4H-pyran-2-yl)benzaldehyde DMS9DPO MI TTK3PY9 DMS9DPO MN DNA-dependent protein kinase catalytic (PRKDC) DMS9DPO MT DTT DMS9DPO MA Inhibitor DMS9DPO RN Pyranone, thiopyranone, and pyridone inhibitors of phosphatidylinositol 3-kinase related kinases. Structure-activity relationships for DNA-dependen... J Med Chem. 2007 Apr 19;50(8):1958-72. DMS9DPO RU https://pubmed.ncbi.nlm.nih.gov/17371003 DM2VNLK DI DM2VNLK DM2VNLK DN 3-(6-morpholino-4-oxo-4H-pyran-2-yl)benzoic acid DM2VNLK MI TTK3PY9 DM2VNLK MN DNA-dependent protein kinase catalytic (PRKDC) DM2VNLK MT DTT DM2VNLK MA Inhibitor DM2VNLK RN Pyranone, thiopyranone, and pyridone inhibitors of phosphatidylinositol 3-kinase related kinases. Structure-activity relationships for DNA-dependen... J Med Chem. 2007 Apr 19;50(8):1958-72. DM2VNLK RU https://pubmed.ncbi.nlm.nih.gov/17371003 DM2J63V DI DM2J63V DM2J63V DN 3-(6-morpholino-4-oxo-4H-pyran-2-yl)benzonitrile DM2J63V MI TTK3PY9 DM2J63V MN DNA-dependent protein kinase catalytic (PRKDC) DM2J63V MT DTT DM2J63V MA Inhibitor DM2J63V RN Pyranone, thiopyranone, and pyridone inhibitors of phosphatidylinositol 3-kinase related kinases. Structure-activity relationships for DNA-dependen... J Med Chem. 2007 Apr 19;50(8):1958-72. DM2J63V RU https://pubmed.ncbi.nlm.nih.gov/17371003 DMS2OY9 DI DMS2OY9 DMS2OY9 DN 3-(6-morpholino-9H-purin-2-yl)phenol DMS2OY9 MI TTCJG29 DMS2OY9 MN Serine/threonine-protein kinase mTOR (mTOR) DMS2OY9 MT DTT DMS2OY9 MA Inhibitor DMS2OY9 RN Novel purine and pyrazolo[3,4-d]pyrimidine inhibitors of PI3 kinase-alpha: Hit to lead studies. Bioorg Med Chem Lett. 2010 Jan 15;20(2):636-9. DMS2OY9 RU https://pubmed.ncbi.nlm.nih.gov/19969455 DM8ZUBY DI DM8ZUBY DM8ZUBY DN 3-(6-phenyl-2,4'-bipyridin-4-yl)phenol DM8ZUBY MI TTGTQHC DM8ZUBY MN DNA topoisomerase I (TOP1) DM8ZUBY MT DTT DM8ZUBY MA Inhibitor DM8ZUBY RN Synthesis, topoisomerase I and II inhibitory activity, cytotoxicity, and structure-activity relationship study of hydroxylated 2,4-diphenyl-6-aryl ... Bioorg Med Chem. 2010 May 1;18(9):3066-77. DM8ZUBY RU https://pubmed.ncbi.nlm.nih.gov/20392646 DMZ53N4 DI DMZ53N4 DMZ53N4 DN 3-(7-methyl-1,8-naphthyridin-2-yl)benzonitrile DMZ53N4 MI TTHS256 DMZ53N4 MN Metabotropic glutamate receptor 5 (mGluR5) DMZ53N4 MT DTT DMZ53N4 MA Inhibitor DMZ53N4 RN Synthesis and SAR comparison of regioisomeric aryl naphthyridines as potent mGlu5 receptor antagonists. Bioorg Med Chem Lett. 2007 Dec 1;17(23):6525-8. DMZ53N4 RU https://pubmed.ncbi.nlm.nih.gov/17936624 DMDIQ7H DI DMDIQ7H DMDIQ7H DN 3-(9-Acridinylamino)-5-(hydroxymethyl)aniline (AHMA) DMDIQ7H MI TT2GPK3 DMDIQ7H MN DNA topoisomerase (TOP) DMDIQ7H MT DTT DMDIQ7H MA Inhibitor DMDIQ7H RN Crystallization and preliminary X-ray analysis of anti-cancer agent 3-(9-acridinylamino)-5-(hydroxymethyl)aniline complexed with the DNA hexamer d(CGTACG)2. Biochim Biophys Acta. 2003 Jan 3;1625(1):27-9. DMDIQ7H RU https://pubmed.ncbi.nlm.nih.gov/12527422 DM5497S DI DM5497S DM5497S DN 3-(aminomethyl)-4-(furan-2-yl)butanoic acid DM5497S MI TTFK1JQ DM5497S MN Voltage-gated calcium channel alpha-2/delta-1 (CACNA2D1) DM5497S MT DTT DM5497S MA Inhibitor DM5497S RN Heteroaromatic side-chain analogs of pregabalin. Bioorg Med Chem Lett. 2006 May 1;16(9):2329-32. DM5497S RU https://pubmed.ncbi.nlm.nih.gov/16099652 DMG3FPJ DI DMG3FPJ DMG3FPJ DN 3-(aminomethyl)-4-(furan-3-yl)butanoic acid DMG3FPJ MI TTFK1JQ DMG3FPJ MN Voltage-gated calcium channel alpha-2/delta-1 (CACNA2D1) DMG3FPJ MT DTT DMG3FPJ MA Inhibitor DMG3FPJ RN Heteroaromatic side-chain analogs of pregabalin. Bioorg Med Chem Lett. 2006 May 1;16(9):2329-32. DMG3FPJ RU https://pubmed.ncbi.nlm.nih.gov/16099652 DMT72FB DI DMT72FB DMT72FB DN 3-(aminomethyl)-4-(thiophen-2-yl)butanoic acid DMT72FB MI TTFK1JQ DMT72FB MN Voltage-gated calcium channel alpha-2/delta-1 (CACNA2D1) DMT72FB MT DTT DMT72FB MA Inhibitor DMT72FB RN Heteroaromatic side-chain analogs of pregabalin. Bioorg Med Chem Lett. 2006 May 1;16(9):2329-32. DMT72FB RU https://pubmed.ncbi.nlm.nih.gov/16099652 DMWO1Z7 DI DMWO1Z7 DMWO1Z7 DN 3-(aminomethyl)-4-(thiophen-3-yl)butanoic acid DMWO1Z7 MI TTFK1JQ DMWO1Z7 MN Voltage-gated calcium channel alpha-2/delta-1 (CACNA2D1) DMWO1Z7 MT DTT DMWO1Z7 MA Inhibitor DMWO1Z7 RN Heteroaromatic side-chain analogs of pregabalin. Bioorg Med Chem Lett. 2006 May 1;16(9):2329-32. DMWO1Z7 RU https://pubmed.ncbi.nlm.nih.gov/16099652 DMPFH15 DI DMPFH15 DMPFH15 DN 3-(Aminooxy)propan-1-amine hydrochloride DMPFH15 MI TTUMGNO DMPFH15 MN Ornithine decarboxylase (ODC1) DMPFH15 MT DTT DMPFH15 MA Inhibitor DMPFH15 RN Selective delivery of 2-hydroxy APA to Trypanosoma brucei using the melamine motif. Bioorg Med Chem Lett. 2010 Aug 1;20(15):4364-6. DMPFH15 RU https://pubmed.ncbi.nlm.nih.gov/20615694 DM58GRA DI DM58GRA DM58GRA DN 3-(benzo[b]thiophen-5-yl)-3-benzylpyrrolidine DM58GRA MI TTQ6VDM DM58GRA MN Voltage-gated potassium channel Kv11.1 (KCNH2) DM58GRA MT DTT DM58GRA MA Inhibitor DM58GRA RN Novel 3,3-disubstituted pyrrolidines as selective triple serotonin/norepinephrine/dopamine reuptake inhibitors. Bioorg Med Chem Lett. 2008 Dec 1;18(23):6062-6. DM58GRA RU https://pubmed.ncbi.nlm.nih.gov/18954985 DMPFH8U DI DMPFH8U DMPFH8U DN 3-(benzo[d]oxazol-2-yl)phenyl propylcarbamate DMPFH8U MI TTDP1UC DMPFH8U MN Fatty acid amide hydrolase (FAAH) DMPFH8U MT DTT DMPFH8U MA Inhibitor DMPFH8U RN Chiral 3-(4,5-dihydrooxazol-2-yl)phenyl alkylcarbamates as novel FAAH inhibitors: Insight into FAAH enantioselectivity by molecular docking and int... Eur J Med Chem. 2009 Oct;44(10):4179-91. DMPFH8U RU https://pubmed.ncbi.nlm.nih.gov/19539407 DMD4WHN DI DMD4WHN DMD4WHN DN 3-(benzyloxy)-2-(4-chlorophenyl)thiazolidin-4-one DMD4WHN MI TTW0CMT DMD4WHN MN Voltage-gated potassium channel Kv1.5 (KCNA5) DMD4WHN MT DTT DMD4WHN MA Inhibitor DMD4WHN RN Evolution of thiazolidine-based blockers of human Kv1.5 for the treatment of atrial arrhythmias. Bioorg Med Chem Lett. 2007 Jan 1;17(1):282-4. DMD4WHN RU https://pubmed.ncbi.nlm.nih.gov/17095219 DMDNEKR DI DMDNEKR DMDNEKR DN 3-(benzyloxy)-9H-pyrido[3,4-b]indole DMDNEKR MI TT1MPAY DMDNEKR MN GABA(A) receptor alpha-1 (GABRA1) DMDNEKR MT DTT DMDNEKR MA Inhibitor DMDNEKR RN Design, synthesis, and subtype selectivity of 3,6-disubstituted -carbolines at Bz/GABA(A)ergic receptors. SAR and studies directed toward agents f... Bioorg Med Chem. 2010 Nov 1;18(21):7548-64. DMDNEKR RU https://pubmed.ncbi.nlm.nih.gov/20888240 DMDNEKR DI DMDNEKR DMDNEKR DN 3-(benzyloxy)-9H-pyrido[3,4-b]indole DMDNEKR MI TTBMV1G DMDNEKR MN GABA(A) receptor alpha-2 (GABRA2) DMDNEKR MT DTT DMDNEKR MA Inhibitor DMDNEKR RN Design, synthesis, and subtype selectivity of 3,6-disubstituted -carbolines at Bz/GABA(A)ergic receptors. SAR and studies directed toward agents f... Bioorg Med Chem. 2010 Nov 1;18(21):7548-64. DMDNEKR RU https://pubmed.ncbi.nlm.nih.gov/20888240 DMDNEKR DI DMDNEKR DMDNEKR DN 3-(benzyloxy)-9H-pyrido[3,4-b]indole DMDNEKR MI TT37EDJ DMDNEKR MN GABA(A) receptor alpha-3 (GABRA3) DMDNEKR MT DTT DMDNEKR MA Inhibitor DMDNEKR RN Design, synthesis, and subtype selectivity of 3,6-disubstituted -carbolines at Bz/GABA(A)ergic receptors. SAR and studies directed toward agents f... Bioorg Med Chem. 2010 Nov 1;18(21):7548-64. DMDNEKR RU https://pubmed.ncbi.nlm.nih.gov/20888240 DMDNEKR DI DMDNEKR DMDNEKR DN 3-(benzyloxy)-9H-pyrido[3,4-b]indole DMDNEKR MI TTNZPQ1 DMDNEKR MN GABA(A) receptor alpha-5 (GABRA5) DMDNEKR MT DTT DMDNEKR MA Inhibitor DMDNEKR RN Design, synthesis, and subtype selectivity of 3,6-disubstituted -carbolines at Bz/GABA(A)ergic receptors. SAR and studies directed toward agents f... Bioorg Med Chem. 2010 Nov 1;18(21):7548-64. DMDNEKR RU https://pubmed.ncbi.nlm.nih.gov/20888240 DMDNEKR DI DMDNEKR DMDNEKR DN 3-(benzyloxy)-9H-pyrido[3,4-b]indole DMDNEKR MI TT06RH5 DMDNEKR MN GABA(A) receptor gamma-2 (GABRG2) DMDNEKR MT DTT DMDNEKR MA Inhibitor DMDNEKR RN Design, synthesis, and subtype selectivity of 3,6-disubstituted -carbolines at Bz/GABA(A)ergic receptors. SAR and studies directed toward agents f... Bioorg Med Chem. 2010 Nov 1;18(21):7548-64. DMDNEKR RU https://pubmed.ncbi.nlm.nih.gov/20888240 DMDNEKR DI DMDNEKR DMDNEKR DN 3-(benzyloxy)-9H-pyrido[3,4-b]indole DMDNEKR MI TTNJYV2 DMDNEKR MN Gamma-aminobutyric acid receptor (GAR) DMDNEKR MT DTT DMDNEKR MA Inhibitor DMDNEKR RN Design, synthesis, and subtype selectivity of 3,6-disubstituted -carbolines at Bz/GABA(A)ergic receptors. SAR and studies directed toward agents f... Bioorg Med Chem. 2010 Nov 1;18(21):7548-64. DMDNEKR RU https://pubmed.ncbi.nlm.nih.gov/20888240 DM35VEI DI DM35VEI DM35VEI DN 3-(Benzyloxy)Pyridin-2-Amine DM35VEI MI TTXZEAJ DM35VEI MN Leukotriene A-4 hydrolase (LTA4H) DM35VEI MT DTT DM35VEI MA Inhibitor DM35VEI RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DM35VEI RU https://pubmed.ncbi.nlm.nih.gov/17139284 DM35VEI DI DM35VEI DM35VEI DN 3-(Benzyloxy)Pyridin-2-Amine DM35VEI MI TTQBR95 DM35VEI MN Stress-activated protein kinase 2a (p38 alpha) DM35VEI MT DTT DM35VEI MA Inhibitor DM35VEI RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DM35VEI RU https://pubmed.ncbi.nlm.nih.gov/17139284 DM4GWJO DI DM4GWJO DM4GWJO DN 3-(biphenyl-4-yl)-1-(oxazol-2-yl)propan-1-one DM4GWJO MI TTDP1UC DM4GWJO MN Fatty acid amide hydrolase (FAAH) DM4GWJO MT DTT DM4GWJO MA Inhibitor DM4GWJO RN Optimization of alpha-ketooxazole inhibitors of fatty acid amide hydrolase. J Med Chem. 2008 Feb 28;51(4):937-47. DM4GWJO RU https://pubmed.ncbi.nlm.nih.gov/18247553 DM8PM0E DI DM8PM0E DM8PM0E DN 3-(butylsulfinyl)-1,1,1-trifluoropropan-2-one DM8PM0E MI TTMF541 DM8PM0E MN Liver carboxylesterase (CES1) DM8PM0E MT DTT DM8PM0E MA Inhibitor DM8PM0E RN Influence of sulfur oxidation state and steric bulk upon trifluoromethyl ketone (TFK) binding kinetics to carboxylesterases and fatty acid amide hy... Bioorg Med Chem. 2008 Feb 15;16(4):2114-30. DM8PM0E RU https://pubmed.ncbi.nlm.nih.gov/18023188 DM8T2OX DI DM8T2OX DM8T2OX DN 3-(butylthio)-1,1,1-trifluoropropan-2-one DM8T2OX MI TTMF541 DM8T2OX MN Liver carboxylesterase (CES1) DM8T2OX MT DTT DM8T2OX MA Inhibitor DM8T2OX RN Influence of sulfur oxidation state and steric bulk upon trifluoromethyl ketone (TFK) binding kinetics to carboxylesterases and fatty acid amide hy... Bioorg Med Chem. 2008 Feb 15;16(4):2114-30. DM8T2OX RU https://pubmed.ncbi.nlm.nih.gov/18023188 DMWJ6UD DI DMWJ6UD DMWJ6UD DN 3-(decylsulfinyl)-1,1,1-trifluoropropan-2-one DMWJ6UD MI TTDP1UC DMWJ6UD MN Fatty acid amide hydrolase (FAAH) DMWJ6UD MT DTT DMWJ6UD MA Inhibitor DMWJ6UD RN Influence of sulfur oxidation state and steric bulk upon trifluoromethyl ketone (TFK) binding kinetics to carboxylesterases and fatty acid amide hy... Bioorg Med Chem. 2008 Feb 15;16(4):2114-30. DMWJ6UD RU https://pubmed.ncbi.nlm.nih.gov/18023188 DMWJ6UD DI DMWJ6UD DMWJ6UD DN 3-(decylsulfinyl)-1,1,1-trifluoropropan-2-one DMWJ6UD MI TTMF541 DMWJ6UD MN Liver carboxylesterase (CES1) DMWJ6UD MT DTT DMWJ6UD MA Inhibitor DMWJ6UD RN Influence of sulfur oxidation state and steric bulk upon trifluoromethyl ketone (TFK) binding kinetics to carboxylesterases and fatty acid amide hy... Bioorg Med Chem. 2008 Feb 15;16(4):2114-30. DMWJ6UD RU https://pubmed.ncbi.nlm.nih.gov/18023188 DMF27YT DI DMF27YT DMF27YT DN 3-(decylsulfonyl)-1,1,1-trifluoropropan-2-one DMF27YT MI TTDP1UC DMF27YT MN Fatty acid amide hydrolase (FAAH) DMF27YT MT DTT DMF27YT MA Inhibitor DMF27YT RN Influence of sulfur oxidation state and steric bulk upon trifluoromethyl ketone (TFK) binding kinetics to carboxylesterases and fatty acid amide hy... Bioorg Med Chem. 2008 Feb 15;16(4):2114-30. DMF27YT RU https://pubmed.ncbi.nlm.nih.gov/18023188 DMF27YT DI DMF27YT DMF27YT DN 3-(decylsulfonyl)-1,1,1-trifluoropropan-2-one DMF27YT MI TTMF541 DMF27YT MN Liver carboxylesterase (CES1) DMF27YT MT DTT DMF27YT MA Inhibitor DMF27YT RN Influence of sulfur oxidation state and steric bulk upon trifluoromethyl ketone (TFK) binding kinetics to carboxylesterases and fatty acid amide hy... Bioorg Med Chem. 2008 Feb 15;16(4):2114-30. DMF27YT RU https://pubmed.ncbi.nlm.nih.gov/18023188 DM1Y6L8 DI DM1Y6L8 DM1Y6L8 DN 3-(decylthio)-1,1,1-trifluoropropan-2-one DM1Y6L8 MI TTDP1UC DM1Y6L8 MN Fatty acid amide hydrolase (FAAH) DM1Y6L8 MT DTT DM1Y6L8 MA Inhibitor DM1Y6L8 RN Influence of sulfur oxidation state and steric bulk upon trifluoromethyl ketone (TFK) binding kinetics to carboxylesterases and fatty acid amide hy... Bioorg Med Chem. 2008 Feb 15;16(4):2114-30. DM1Y6L8 RU https://pubmed.ncbi.nlm.nih.gov/18023188 DM1Y6L8 DI DM1Y6L8 DM1Y6L8 DN 3-(decylthio)-1,1,1-trifluoropropan-2-one DM1Y6L8 MI TTMF541 DM1Y6L8 MN Liver carboxylesterase (CES1) DM1Y6L8 MT DTT DM1Y6L8 MA Inhibitor DM1Y6L8 RN Influence of sulfur oxidation state and steric bulk upon trifluoromethyl ketone (TFK) binding kinetics to carboxylesterases and fatty acid amide hy... Bioorg Med Chem. 2008 Feb 15;16(4):2114-30. DM1Y6L8 RU https://pubmed.ncbi.nlm.nih.gov/18023188 DM2JBQI DI DM2JBQI DM2JBQI DN 3-(dibutylamino)-1-(4-hexylphenyl)propan-1-one DM2JBQI MI TTTSEPU DM2JBQI MN Thyroid hormone receptor alpha (THRA) DM2JBQI MT DTT DM2JBQI MA Inhibitor DM2JBQI RN Inhibitors of the interaction of a thyroid hormone receptor and coactivators: preliminary structure-activity relationships. J Med Chem. 2007 Nov 1;50(22):5269-80. DM2JBQI RU https://pubmed.ncbi.nlm.nih.gov/17918822 DM2JBQI DI DM2JBQI DM2JBQI DN 3-(dibutylamino)-1-(4-hexylphenyl)propan-1-one DM2JBQI MI TTGER3L DM2JBQI MN Thyroid hormone receptor beta (THRB) DM2JBQI MT DTT DM2JBQI MA Inhibitor DM2JBQI RN Inhibitors of the interaction of a thyroid hormone receptor and coactivators: preliminary structure-activity relationships. J Med Chem. 2007 Nov 1;50(22):5269-80. DM2JBQI RU https://pubmed.ncbi.nlm.nih.gov/17918822 DMG5VMH DI DMG5VMH DMG5VMH DN 3-(dimethylamino)-1-(4-heptylphenyl)propan-1-one DMG5VMH MI TTGER3L DMG5VMH MN Thyroid hormone receptor beta (THRB) DMG5VMH MT DTT DMG5VMH MA Inhibitor DMG5VMH RN Improvement of pharmacological properties of irreversible thyroid receptor coactivator binding inhibitors. J Med Chem. 2009 Jul 9;52(13):3892-901. DMG5VMH RU https://pubmed.ncbi.nlm.nih.gov/19469546 DMG5VMH DI DMG5VMH DMG5VMH DN 3-(dimethylamino)-1-(4-heptylphenyl)propan-1-one DMG5VMH MI TTQ6VDM DMG5VMH MN Voltage-gated potassium channel Kv11.1 (KCNH2) DMG5VMH MT DTT DMG5VMH MA Inhibitor DMG5VMH RN Improvement of pharmacological properties of irreversible thyroid receptor coactivator binding inhibitors. J Med Chem. 2009 Jul 9;52(13):3892-901. DMG5VMH RU https://pubmed.ncbi.nlm.nih.gov/19469546 DMJYCHG DI DMJYCHG DMJYCHG DN 3-(dimethylamino)-1-(4-hexylphenyl)propan-1-one DMJYCHG MI TTTSEPU DMJYCHG MN Thyroid hormone receptor alpha (THRA) DMJYCHG MT DTT DMJYCHG MA Inhibitor DMJYCHG RN Inhibitors of the interaction of a thyroid hormone receptor and coactivators: preliminary structure-activity relationships. J Med Chem. 2007 Nov 1;50(22):5269-80. DMJYCHG RU https://pubmed.ncbi.nlm.nih.gov/17918822 DMJYCHG DI DMJYCHG DMJYCHG DN 3-(dimethylamino)-1-(4-hexylphenyl)propan-1-one DMJYCHG MI TTGER3L DMJYCHG MN Thyroid hormone receptor beta (THRB) DMJYCHG MT DTT DMJYCHG MA Inhibitor DMJYCHG RN Inhibitors of the interaction of a thyroid hormone receptor and coactivators: preliminary structure-activity relationships. J Med Chem. 2007 Nov 1;50(22):5269-80. DMJYCHG RU https://pubmed.ncbi.nlm.nih.gov/17918822 DMM05G2 DI DMM05G2 DMM05G2 DN 3-(dimethylamino)phenyl phenylcarbamate DMM05G2 MI TT1RS9F DMM05G2 MN Acetylcholinesterase (AChE) DMM05G2 MT DTT DMM05G2 MA Inhibitor DMM05G2 RN Long-acting anticholinesterases for myasthenia gravis: synthesis and activities of quaternary phenylcarbamates of neostigmine, pyridostigmine and physostigmine. Bioorg Med Chem. 2010 Jul 1;18(13):4687-93. DMM05G2 RU https://pubmed.ncbi.nlm.nih.gov/20627738 DMM05G2 DI DMM05G2 DMM05G2 DN 3-(dimethylamino)phenyl phenylcarbamate DMM05G2 MI TTEB0GD DMM05G2 MN Cholinesterase (BCHE) DMM05G2 MT DTT DMM05G2 MA Inhibitor DMM05G2 RN Long-acting anticholinesterases for myasthenia gravis: synthesis and activities of quaternary phenylcarbamates of neostigmine, pyridostigmine and physostigmine. Bioorg Med Chem. 2010 Jul 1;18(13):4687-93. DMM05G2 RU https://pubmed.ncbi.nlm.nih.gov/20627738 DM7AG6Y DI DM7AG6Y DM7AG6Y DN 3-(dodecylsulfinyl)-1,1,1-trifluoropropan-2-one DM7AG6Y MI TTDP1UC DM7AG6Y MN Fatty acid amide hydrolase (FAAH) DM7AG6Y MT DTT DM7AG6Y MA Inhibitor DM7AG6Y RN Influence of sulfur oxidation state and steric bulk upon trifluoromethyl ketone (TFK) binding kinetics to carboxylesterases and fatty acid amide hy... Bioorg Med Chem. 2008 Feb 15;16(4):2114-30. DM7AG6Y RU https://pubmed.ncbi.nlm.nih.gov/18023188 DM7AG6Y DI DM7AG6Y DM7AG6Y DN 3-(dodecylsulfinyl)-1,1,1-trifluoropropan-2-one DM7AG6Y MI TTMF541 DM7AG6Y MN Liver carboxylesterase (CES1) DM7AG6Y MT DTT DM7AG6Y MA Inhibitor DM7AG6Y RN Influence of sulfur oxidation state and steric bulk upon trifluoromethyl ketone (TFK) binding kinetics to carboxylesterases and fatty acid amide hy... Bioorg Med Chem. 2008 Feb 15;16(4):2114-30. DM7AG6Y RU https://pubmed.ncbi.nlm.nih.gov/18023188 DMPRCS0 DI DMPRCS0 DMPRCS0 DN 3-(dodecylsulfonyl)-1,1,1-trifluoropropan-2-one DMPRCS0 MI TTDP1UC DMPRCS0 MN Fatty acid amide hydrolase (FAAH) DMPRCS0 MT DTT DMPRCS0 MA Inhibitor DMPRCS0 RN Influence of sulfur oxidation state and steric bulk upon trifluoromethyl ketone (TFK) binding kinetics to carboxylesterases and fatty acid amide hy... Bioorg Med Chem. 2008 Feb 15;16(4):2114-30. DMPRCS0 RU https://pubmed.ncbi.nlm.nih.gov/18023188 DMPRCS0 DI DMPRCS0 DMPRCS0 DN 3-(dodecylsulfonyl)-1,1,1-trifluoropropan-2-one DMPRCS0 MI TTMF541 DMPRCS0 MN Liver carboxylesterase (CES1) DMPRCS0 MT DTT DMPRCS0 MA Inhibitor DMPRCS0 RN Influence of sulfur oxidation state and steric bulk upon trifluoromethyl ketone (TFK) binding kinetics to carboxylesterases and fatty acid amide hy... Bioorg Med Chem. 2008 Feb 15;16(4):2114-30. DMPRCS0 RU https://pubmed.ncbi.nlm.nih.gov/18023188 DM71EMN DI DM71EMN DM71EMN DN 3-(ethoxycarbonyl)phenylboronic acid DM71EMN MI TTDP1UC DM71EMN MN Fatty acid amide hydrolase (FAAH) DM71EMN MT DTT DM71EMN MA Inhibitor DM71EMN RN Discovery of boronic acids as novel and potent inhibitors of fatty acid amide hydrolase. J Med Chem. 2008 Nov 27;51(22):7057-60. DM71EMN RU https://pubmed.ncbi.nlm.nih.gov/18983140 DMM2AR3 DI DMM2AR3 DMM2AR3 DN 3-(furan-3-yl)-1H-indole DMM2AR3 MI TTTB4UP DMM2AR3 MN Inosine-5'-monophosphate dehydrogenase 2 (IMPDH2) DMM2AR3 MT DTT DMM2AR3 MA Inhibitor DMM2AR3 RN Low molecular weight indole fragments as IMPDH inhibitors. Bioorg Med Chem Lett. 2006 May 1;16(9):2535-8. DMM2AR3 RU https://pubmed.ncbi.nlm.nih.gov/16483769 DM6L4J8 DI DM6L4J8 DM6L4J8 DN 3-(furan-3-yl)-1-methyl-1H-indole DM6L4J8 MI TTTB4UP DM6L4J8 MN Inosine-5'-monophosphate dehydrogenase 2 (IMPDH2) DM6L4J8 MT DTT DM6L4J8 MA Inhibitor DM6L4J8 RN Low molecular weight indole fragments as IMPDH inhibitors. Bioorg Med Chem Lett. 2006 May 1;16(9):2535-8. DM6L4J8 RU https://pubmed.ncbi.nlm.nih.gov/16483769 DMQZU9G DI DMQZU9G DMQZU9G DN 3-(heptyloxy)benzoic acid DMQZU9G MI TT0OFWN DMQZU9G MN Pseudomonas UDP-3-O-acyl-GlcNAc deacetylase (Pseudo lpxC) DMQZU9G MT DTT DMQZU9G MA Inhibitor DMQZU9G RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DMQZU9G RU https://pubmed.ncbi.nlm.nih.gov/10592235 DMKHNTY DI DMKHNTY DMKHNTY DN 3-(hexa-1,3-dienyloxy)-9H-pyrido[3,4-b]indole DMKHNTY MI TT1MPAY DMKHNTY MN GABA(A) receptor alpha-1 (GABRA1) DMKHNTY MT DTT DMKHNTY MA Inhibitor DMKHNTY RN Design, synthesis, and subtype selectivity of 3,6-disubstituted -carbolines at Bz/GABA(A)ergic receptors. SAR and studies directed toward agents f... Bioorg Med Chem. 2010 Nov 1;18(21):7548-64. DMKHNTY RU https://pubmed.ncbi.nlm.nih.gov/20888240 DMKHNTY DI DMKHNTY DMKHNTY DN 3-(hexa-1,3-dienyloxy)-9H-pyrido[3,4-b]indole DMKHNTY MI TTBMV1G DMKHNTY MN GABA(A) receptor alpha-2 (GABRA2) DMKHNTY MT DTT DMKHNTY MA Inhibitor DMKHNTY RN Design, synthesis, and subtype selectivity of 3,6-disubstituted -carbolines at Bz/GABA(A)ergic receptors. SAR and studies directed toward agents f... Bioorg Med Chem. 2010 Nov 1;18(21):7548-64. DMKHNTY RU https://pubmed.ncbi.nlm.nih.gov/20888240 DMKHNTY DI DMKHNTY DMKHNTY DN 3-(hexa-1,3-dienyloxy)-9H-pyrido[3,4-b]indole DMKHNTY MI TT37EDJ DMKHNTY MN GABA(A) receptor alpha-3 (GABRA3) DMKHNTY MT DTT DMKHNTY MA Inhibitor DMKHNTY RN Design, synthesis, and subtype selectivity of 3,6-disubstituted -carbolines at Bz/GABA(A)ergic receptors. SAR and studies directed toward agents f... Bioorg Med Chem. 2010 Nov 1;18(21):7548-64. DMKHNTY RU https://pubmed.ncbi.nlm.nih.gov/20888240 DMKHNTY DI DMKHNTY DMKHNTY DN 3-(hexa-1,3-dienyloxy)-9H-pyrido[3,4-b]indole DMKHNTY MI TTNZPQ1 DMKHNTY MN GABA(A) receptor alpha-5 (GABRA5) DMKHNTY MT DTT DMKHNTY MA Inhibitor DMKHNTY RN Design, synthesis, and subtype selectivity of 3,6-disubstituted -carbolines at Bz/GABA(A)ergic receptors. SAR and studies directed toward agents f... Bioorg Med Chem. 2010 Nov 1;18(21):7548-64. DMKHNTY RU https://pubmed.ncbi.nlm.nih.gov/20888240 DMKHNTY DI DMKHNTY DMKHNTY DN 3-(hexa-1,3-dienyloxy)-9H-pyrido[3,4-b]indole DMKHNTY MI TT06RH5 DMKHNTY MN GABA(A) receptor gamma-2 (GABRG2) DMKHNTY MT DTT DMKHNTY MA Inhibitor DMKHNTY RN Design, synthesis, and subtype selectivity of 3,6-disubstituted -carbolines at Bz/GABA(A)ergic receptors. SAR and studies directed toward agents f... Bioorg Med Chem. 2010 Nov 1;18(21):7548-64. DMKHNTY RU https://pubmed.ncbi.nlm.nih.gov/20888240 DMKHNTY DI DMKHNTY DMKHNTY DN 3-(hexa-1,3-dienyloxy)-9H-pyrido[3,4-b]indole DMKHNTY MI TTNJYV2 DMKHNTY MN Gamma-aminobutyric acid receptor (GAR) DMKHNTY MT DTT DMKHNTY MA Inhibitor DMKHNTY RN Design, synthesis, and subtype selectivity of 3,6-disubstituted -carbolines at Bz/GABA(A)ergic receptors. SAR and studies directed toward agents f... Bioorg Med Chem. 2010 Nov 1;18(21):7548-64. DMKHNTY RU https://pubmed.ncbi.nlm.nih.gov/20888240 DMM52LC DI DMM52LC DMM52LC DN 3-(imidazolylmethyl)-4'-methoxyflavone DMM52LC MI TTSZLWK DMM52LC MN Aromatase (CYP19A1) DMM52LC MT DTT DMM52LC MA Inhibitor DMM52LC RN Lead optimization providing a series of flavone derivatives as potent nonsteroidal inhibitors of the cytochrome P450 aromatase enzyme. J Med Chem. 2006 Jul 27;49(15):4777-80. DMM52LC RU https://pubmed.ncbi.nlm.nih.gov/16854084 DMX2LT5 DI DMX2LT5 DMX2LT5 DN 3-(imidazolylmethyl)-4'-nitroflavone DMX2LT5 MI TTSZLWK DMX2LT5 MN Aromatase (CYP19A1) DMX2LT5 MT DTT DMX2LT5 MA Inhibitor DMX2LT5 RN Lead optimization providing a series of flavone derivatives as potent nonsteroidal inhibitors of the cytochrome P450 aromatase enzyme. J Med Chem. 2006 Jul 27;49(15):4777-80. DMX2LT5 RU https://pubmed.ncbi.nlm.nih.gov/16854084 DML63MX DI DML63MX DML63MX DN 3-(imidazolylmethyl)-7-methoxy-4'-nitroflavone DML63MX MI TTSZLWK DML63MX MN Aromatase (CYP19A1) DML63MX MT DTT DML63MX MA Inhibitor DML63MX RN Lead optimization providing a series of flavone derivatives as potent nonsteroidal inhibitors of the cytochrome P450 aromatase enzyme. J Med Chem. 2006 Jul 27;49(15):4777-80. DML63MX RU https://pubmed.ncbi.nlm.nih.gov/16854084 DMLI7F4 DI DMLI7F4 DMLI7F4 DN 3-(imidazolylmethyl)flavone DMLI7F4 MI TTSZLWK DMLI7F4 MN Aromatase (CYP19A1) DMLI7F4 MT DTT DMLI7F4 MA Inhibitor DMLI7F4 RN Lead optimization providing a series of flavone derivatives as potent nonsteroidal inhibitors of the cytochrome P450 aromatase enzyme. J Med Chem. 2006 Jul 27;49(15):4777-80. DMLI7F4 RU https://pubmed.ncbi.nlm.nih.gov/16854084 DM3EV9N DI DM3EV9N DM3EV9N DN 3-(indole-3-yl)-4-phenyl-1H-pyrrole-2,5-dione DM3EV9N MI TT9VGXW DM3EV9N MN Angiopoietin 1 receptor (TEK) DM3EV9N MT DTT DM3EV9N MA Inhibitor DM3EV9N RN Design, synthesis, and biological evaluation of 3,4-diarylmaleimides as angiogenesis inhibitors. J Med Chem. 2006 Feb 23;49(4):1271-81. DM3EV9N RU https://pubmed.ncbi.nlm.nih.gov/16480264 DM3EV9N DI DM3EV9N DM3EV9N DN 3-(indole-3-yl)-4-phenyl-1H-pyrrole-2,5-dione DM3EV9N MI TTH6V3D DM3EV9N MN Cyclin-dependent kinase 1 (CDK1) DM3EV9N MT DTT DM3EV9N MA Inhibitor DM3EV9N RN Design, synthesis, and biological evaluation of 3,4-diarylmaleimides as angiogenesis inhibitors. J Med Chem. 2006 Feb 23;49(4):1271-81. DM3EV9N RU https://pubmed.ncbi.nlm.nih.gov/16480264 DM3EV9N DI DM3EV9N DM3EV9N DN 3-(indole-3-yl)-4-phenyl-1H-pyrrole-2,5-dione DM3EV9N MI TT7HF4W DM3EV9N MN Cyclin-dependent kinase 2 (CDK2) DM3EV9N MT DTT DM3EV9N MA Inhibitor DM3EV9N RN Design, synthesis, and biological evaluation of 3,4-diarylmaleimides as angiogenesis inhibitors. J Med Chem. 2006 Feb 23;49(4):1271-81. DM3EV9N RU https://pubmed.ncbi.nlm.nih.gov/16480264 DM3EV9N DI DM3EV9N DM3EV9N DN 3-(indole-3-yl)-4-phenyl-1H-pyrrole-2,5-dione DM3EV9N MI TT0PG8F DM3EV9N MN Cyclin-dependent kinase 4 (CDK4) DM3EV9N MT DTT DM3EV9N MA Inhibitor DM3EV9N RN Design, synthesis, and biological evaluation of 3,4-diarylmaleimides as angiogenesis inhibitors. J Med Chem. 2006 Feb 23;49(4):1271-81. DM3EV9N RU https://pubmed.ncbi.nlm.nih.gov/16480264 DM3EV9N DI DM3EV9N DM3EV9N DN 3-(indole-3-yl)-4-phenyl-1H-pyrrole-2,5-dione DM3EV9N MI TTGKNB4 DM3EV9N MN Epidermal growth factor receptor (EGFR) DM3EV9N MT DTT DM3EV9N MA Inhibitor DM3EV9N RN Design, synthesis, and biological evaluation of 3,4-diarylmaleimides as angiogenesis inhibitors. J Med Chem. 2006 Feb 23;49(4):1271-81. DM3EV9N RU https://pubmed.ncbi.nlm.nih.gov/16480264 DM3EV9N DI DM3EV9N DM3EV9N DN 3-(indole-3-yl)-4-phenyl-1H-pyrrole-2,5-dione DM3EV9N MI TTR5TV4 DM3EV9N MN ERBB2 messenger RNA (HER2 mRNA) DM3EV9N MT DTT DM3EV9N MA Inhibitor DM3EV9N RN Design, synthesis, and biological evaluation of 3,4-diarylmaleimides as angiogenesis inhibitors. J Med Chem. 2006 Feb 23;49(4):1271-81. DM3EV9N RU https://pubmed.ncbi.nlm.nih.gov/16480264 DM3EV9N DI DM3EV9N DM3EV9N DN 3-(indole-3-yl)-4-phenyl-1H-pyrrole-2,5-dione DM3EV9N MI TTFCJ7S DM3EV9N MN G1/S-specific cyclin-D1 (CCND1) DM3EV9N MT DTT DM3EV9N MA Inhibitor DM3EV9N RN Design, synthesis, and biological evaluation of 3,4-diarylmaleimides as angiogenesis inhibitors. J Med Chem. 2006 Feb 23;49(4):1271-81. DM3EV9N RU https://pubmed.ncbi.nlm.nih.gov/16480264 DM3EV9N DI DM3EV9N DM3EV9N DN 3-(indole-3-yl)-4-phenyl-1H-pyrrole-2,5-dione DM3EV9N MI TTCEJ4F DM3EV9N MN G1/S-specific cyclin-E1 (CCNE1) DM3EV9N MT DTT DM3EV9N MA Inhibitor DM3EV9N RN Design, synthesis, and biological evaluation of 3,4-diarylmaleimides as angiogenesis inhibitors. J Med Chem. 2006 Feb 23;49(4):1271-81. DM3EV9N RU https://pubmed.ncbi.nlm.nih.gov/16480264 DM3EV9N DI DM3EV9N DM3EV9N DN 3-(indole-3-yl)-4-phenyl-1H-pyrrole-2,5-dione DM3EV9N MI TT9P6OW DM3EV9N MN G2/mitotic-specific cyclin B1 (CCNB1) DM3EV9N MT DTT DM3EV9N MA Inhibitor DM3EV9N RN Design, synthesis, and biological evaluation of 3,4-diarylmaleimides as angiogenesis inhibitors. J Med Chem. 2006 Feb 23;49(4):1271-81. DM3EV9N RU https://pubmed.ncbi.nlm.nih.gov/16480264 DM3EV9N DI DM3EV9N DM3EV9N DN 3-(indole-3-yl)-4-phenyl-1H-pyrrole-2,5-dione DM3EV9N MI TTFJ8Q1 DM3EV9N MN Protein kinase C alpha (PRKCA) DM3EV9N MT DTT DM3EV9N MA Inhibitor DM3EV9N RN Design, synthesis, and biological evaluation of 3,4-diarylmaleimides as angiogenesis inhibitors. J Med Chem. 2006 Feb 23;49(4):1271-81. DM3EV9N RU https://pubmed.ncbi.nlm.nih.gov/16480264 DM3EV9N DI DM3EV9N DM3EV9N DN 3-(indole-3-yl)-4-phenyl-1H-pyrrole-2,5-dione DM3EV9N MI TTBZ7OD DM3EV9N MN Protein kinase C epsilon (PRKCE) DM3EV9N MT DTT DM3EV9N MA Inhibitor DM3EV9N RN Design, synthesis, and biological evaluation of 3,4-diarylmaleimides as angiogenesis inhibitors. J Med Chem. 2006 Feb 23;49(4):1271-81. DM3EV9N RU https://pubmed.ncbi.nlm.nih.gov/16480264 DM3EV9N DI DM3EV9N DM3EV9N DN 3-(indole-3-yl)-4-phenyl-1H-pyrrole-2,5-dione DM3EV9N MI TTRFOXJ DM3EV9N MN Protein kinase C gamma (PRKCG) DM3EV9N MT DTT DM3EV9N MA Inhibitor DM3EV9N RN Design, synthesis, and biological evaluation of 3,4-diarylmaleimides as angiogenesis inhibitors. J Med Chem. 2006 Feb 23;49(4):1271-81. DM3EV9N RU https://pubmed.ncbi.nlm.nih.gov/16480264 DMJDG9C DI DMJDG9C DMJDG9C DN 3-(N-alkylamino) propylphosphonic acid derivative DMJDG9C MI TT9JZCK DMJDG9C MN Sphingosine-1-phosphate receptor 1 (S1PR1) DMJDG9C MT DTT DMJDG9C MA Inhibitor DMJDG9C RN Design and synthesis of conformationally constrained 3-(N-alkylamino)propylphosphonic acids as potent agonists of sphingosine-1-phosphate (S1P) rec... Bioorg Med Chem Lett. 2004 Oct 4;14(19):4861-6. DMJDG9C RU https://pubmed.ncbi.nlm.nih.gov/15341940 DMJRBT1 DI DMJRBT1 DMJRBT1 DN 3-(naphthalen-2-yl)pyridine DMJRBT1 MI TTSZLWK DMJRBT1 MN Aromatase (CYP19A1) DMJRBT1 MT DTT DMJRBT1 MA Inhibitor DMJRBT1 RN In vivo active aldosterone synthase inhibitors with improved selectivity: lead optimization providing a series of pyridine substituted 3,4-dihydro-... J Med Chem. 2008 Dec 25;51(24):8077-87. DMJRBT1 RU https://pubmed.ncbi.nlm.nih.gov/19049427 DMJRBT1 DI DMJRBT1 DMJRBT1 DN 3-(naphthalen-2-yl)pyridine DMJRBT1 MI TTIQUX7 DMJRBT1 MN Steroid 11-beta-hydroxylase (CYP11B1) DMJRBT1 MT DTT DMJRBT1 MA Inhibitor DMJRBT1 RN Novel aldosterone synthase inhibitors with extended carbocyclic skeleton by a combined ligand-based and structure-based drug design approach. J Med Chem. 2008 Oct 9;51(19):6138-49. DMJRBT1 RU https://pubmed.ncbi.nlm.nih.gov/18763754 DM6OCU5 DI DM6OCU5 DM6OCU5 DN 3-(N-propylpiperidin-4-yl)phenol DM6OCU5 MI TTEX248 DM6OCU5 MN Dopamine D2 receptor (D2R) DM6OCU5 MT DTT DM6OCU5 MA Inhibitor DM6OCU5 RN Synthesis and evaluation of a set of 4-phenylpiperidines and 4-phenylpiperazines as D2 receptor ligands and the discovery of the dopaminergic stabi... J Med Chem. 2010 Mar 25;53(6):2510-20. DM6OCU5 RU https://pubmed.ncbi.nlm.nih.gov/20155917 DMJRNI7 DI DMJRNI7 DMJRNI7 DN 3-(Octahydro-indolizin-8-yl)-phenol DMJRNI7 MI TTEX248 DMJRNI7 MN Dopamine D2 receptor (D2R) DMJRNI7 MT DTT DMJRNI7 MA Inhibitor DMJRNI7 RN Pre- and postsynaptic dopaminergic activities of indolizidine and quinolizidine derivatives of 3-(3-hydroxyphenyl)-N-(n-propyl)piperidine (3-PPP). ... J Med Chem. 1990 Mar;33(3):1015-22. DMJRNI7 RU https://pubmed.ncbi.nlm.nih.gov/1968512 DMU1SGX DI DMU1SGX DMU1SGX DN 3-(Octahydro-quinolizin-1-yl)-phenol DMU1SGX MI TTEX248 DMU1SGX MN Dopamine D2 receptor (D2R) DMU1SGX MT DTT DMU1SGX MA Inhibitor DMU1SGX RN Pre- and postsynaptic dopaminergic activities of indolizidine and quinolizidine derivatives of 3-(3-hydroxyphenyl)-N-(n-propyl)piperidine (3-PPP). ... J Med Chem. 1990 Mar;33(3):1015-22. DMU1SGX RU https://pubmed.ncbi.nlm.nih.gov/1968512 DM01BKR DI DM01BKR DM01BKR DN 3-(Octahydro-quinolizin-3-yl)-phenol DM01BKR MI TTEX248 DM01BKR MN Dopamine D2 receptor (D2R) DM01BKR MT DTT DM01BKR MA Inhibitor DM01BKR RN Pre- and postsynaptic dopaminergic activities of indolizidine and quinolizidine derivatives of 3-(3-hydroxyphenyl)-N-(n-propyl)piperidine (3-PPP). ... J Med Chem. 1990 Mar;33(3):1015-22. DM01BKR RU https://pubmed.ncbi.nlm.nih.gov/1968512 DMMRV1N DI DMMRV1N DMMRV1N DN 3-(Oxalyl-Amino)-Naphthalene-2-Carboxylic Acid DMMRV1N MI TTELIN2 DMMRV1N MN PTPN1 messenger RNA (PTPN1 mRNA) DMMRV1N MT DTT DMMRV1N MA Inhibitor DMMRV1N RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMMRV1N RU https://pubmed.ncbi.nlm.nih.gov/17139284 DM2UPQG DI DM2UPQG DM2UPQG DN 3-(phenoxymethyl)-5H-indeno[1,2-c]pyridazin-5-one DM2UPQG MI TTGP7BY DM2UPQG MN Monoamine oxidase type B (MAO-B) DM2UPQG MT DTT DM2UPQG MA Inhibitor DM2UPQG RN Synthesis and monoamine oxidase inhibitory activity of new pyridazine-, pyrimidine- and 1,2,4-triazine-containing tricyclic derivatives. J Med Chem. 2007 Nov 1;50(22):5364-71. DM2UPQG RU https://pubmed.ncbi.nlm.nih.gov/17910428 DMSRHLC DI DMSRHLC DMSRHLC DN 3-(phenylsulfonyl)-1-(piperidin-3-yl)-1H-indole DMSRHLC MI TTJS8PY DMSRHLC MN 5-HT 6 receptor (HTR6) DMSRHLC MT DTT DMSRHLC MA Inhibitor DMSRHLC RN 3-(Arylsulfonyl)-1-(azacyclyl)-1H-indoles are 5-HT(6) receptor modulators. Bioorg Med Chem Lett. 2010 Mar 1;20(5):1657-60. DMSRHLC RU https://pubmed.ncbi.nlm.nih.gov/20138763 DM9QB0X DI DM9QB0X DM9QB0X DN 3-(phenylsulfonyl)-1-(piperidin-4-yl)-1H-indole DM9QB0X MI TTJS8PY DM9QB0X MN 5-HT 6 receptor (HTR6) DM9QB0X MT DTT DM9QB0X MA Inhibitor DM9QB0X RN 3-(Arylsulfonyl)-1-(azacyclyl)-1H-indoles are 5-HT(6) receptor modulators. Bioorg Med Chem Lett. 2010 Mar 1;20(5):1657-60. DM9QB0X RU https://pubmed.ncbi.nlm.nih.gov/20138763 DMVKO5N DI DMVKO5N DMVKO5N DN 3-(phenylsulfonyl)-1-(pyrrolidin-3-yl)-1H-indole DMVKO5N MI TTJS8PY DMVKO5N MN 5-HT 6 receptor (HTR6) DMVKO5N MT DTT DMVKO5N MA Inhibitor DMVKO5N RN 3-(Arylsulfonyl)-1-(azacyclyl)-1H-indoles are 5-HT(6) receptor modulators. Bioorg Med Chem Lett. 2010 Mar 1;20(5):1657-60. DMVKO5N RU https://pubmed.ncbi.nlm.nih.gov/20138763 DMN1DWF DI DMN1DWF DMN1DWF DN 3-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridine DMN1DWF MI TTNDSF4 DMN1DWF MN Proto-oncogene c-Met (MET) DMN1DWF MT DTT DMN1DWF MA Inhibitor DMN1DWF RN Discovery of 4-azaindoles as novel inhibitors of c-Met kinase. Bioorg Med Chem Lett. 2009 May 15;19(10):2780-4. DMN1DWF RU https://pubmed.ncbi.nlm.nih.gov/19369077 DM2ETXB DI DM2ETXB DM2ETXB DN 3-(piperidin-4-yl)-2-(o-tolyloxy)pyridine DM2ETXB MI TTSQIFT DM2ETXB MN 5-HT 1A receptor (HTR1A) DM2ETXB MT DTT DM2ETXB MA Inhibitor DM2ETXB RN Design, synthesis, and pharmacological evaluation of phenoxy pyridyl derivatives as dual norepinephrine reuptake inhibitors and 5-HT1A partial agon... Bioorg Med Chem Lett. 2010 Feb 1;20(3):1114-7. DM2ETXB RU https://pubmed.ncbi.nlm.nih.gov/20031410 DM2ETXB DI DM2ETXB DM2ETXB DN 3-(piperidin-4-yl)-2-(o-tolyloxy)pyridine DM2ETXB MI TTAWNKZ DM2ETXB MN Norepinephrine transporter (NET) DM2ETXB MT DTT DM2ETXB MA Inhibitor DM2ETXB RN Design, synthesis, and pharmacological evaluation of phenoxy pyridyl derivatives as dual norepinephrine reuptake inhibitors and 5-HT1A partial agon... Bioorg Med Chem Lett. 2010 Feb 1;20(3):1114-7. DM2ETXB RU https://pubmed.ncbi.nlm.nih.gov/20031410 DM2ETXB DI DM2ETXB DM2ETXB DN 3-(piperidin-4-yl)-2-(o-tolyloxy)pyridine DM2ETXB MI TT3ROYC DM2ETXB MN Serotonin transporter (SERT) DM2ETXB MT DTT DM2ETXB MA Inhibitor DM2ETXB RN Design, synthesis, and pharmacological evaluation of phenoxy pyridyl derivatives as dual norepinephrine reuptake inhibitors and 5-HT1A partial agon... Bioorg Med Chem Lett. 2010 Feb 1;20(3):1114-7. DM2ETXB RU https://pubmed.ncbi.nlm.nih.gov/20031410 DMMOE40 DI DMMOE40 DMMOE40 DN 3-(Prop-2-Ene-1-Sulfinyl)-Propene-1-Thiol DMMOE40 MI TTEP6RV DMMOE40 MN Glutathione reductase (GR) DMMOE40 MT DTT DMMOE40 MA Inhibitor DMMOE40 RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMMOE40 RU https://pubmed.ncbi.nlm.nih.gov/17139284 DM3EDQ1 DI DM3EDQ1 DM3EDQ1 DN 3-(pyridin-3-yl)prop-2-yn-1-amine DM3EDQ1 MI TTXV4FI DM3EDQ1 MN Albendazole monooxygenase (CYP3A4) DM3EDQ1 MT DTT DM3EDQ1 MA Inhibitor DM3EDQ1 RN Synthetic inhibitors of cytochrome P-450 2A6: inhibitory activity, difference spectra, mechanism of inhibition, and protein cocrystallization. J Med Chem. 2006 Nov 30;49(24):6987-7001. DM3EDQ1 RU https://pubmed.ncbi.nlm.nih.gov/17125252 DMZARSD DI DMZARSD DMZARSD DN 3-(pyridin-4-yl)-1H-indol-6-amine DMZARSD MI TTTB4UP DMZARSD MN Inosine-5'-monophosphate dehydrogenase 2 (IMPDH2) DMZARSD MT DTT DMZARSD MA Inhibitor DMZARSD RN Low molecular weight indole fragments as IMPDH inhibitors. Bioorg Med Chem Lett. 2006 May 1;16(9):2535-8. DMZARSD RU https://pubmed.ncbi.nlm.nih.gov/16483769 DMRFPNE DI DMRFPNE DMRFPNE DN 3-(pyridin-4-yl)-1H-indol-7-amine DMRFPNE MI TTTB4UP DMRFPNE MN Inosine-5'-monophosphate dehydrogenase 2 (IMPDH2) DMRFPNE MT DTT DMRFPNE MA Inhibitor DMRFPNE RN Low molecular weight indole fragments as IMPDH inhibitors. Bioorg Med Chem Lett. 2006 May 1;16(9):2535-8. DMRFPNE RU https://pubmed.ncbi.nlm.nih.gov/16483769 DMNA6LF DI DMNA6LF DMNA6LF DN 3-(tetradecylamino)propylphosphonic acid DMNA6LF MI TT9JZCK DMNA6LF MN Sphingosine-1-phosphate receptor 1 (S1PR1) DMNA6LF MT DTT DMNA6LF MA Inhibitor DMNA6LF RN A rational utilization of high-throughput screening affords selective, orally bioavailable 1-benzyl-3-carboxyazetidine sphingosine-1-phosphate-1 re... J Med Chem. 2004 Dec 30;47(27):6662-5. DMNA6LF RU https://pubmed.ncbi.nlm.nih.gov/15615513 DMMI0UC DI DMMI0UC DMMI0UC DN 3-(thiophen-3-yl)-1H-indol-6-amine DMMI0UC MI TTTB4UP DMMI0UC MN Inosine-5'-monophosphate dehydrogenase 2 (IMPDH2) DMMI0UC MT DTT DMMI0UC MA Inhibitor DMMI0UC RN Low molecular weight indole fragments as IMPDH inhibitors. Bioorg Med Chem Lett. 2006 May 1;16(9):2535-8. DMMI0UC RU https://pubmed.ncbi.nlm.nih.gov/16483769 DMWX4L5 DI DMWX4L5 DMWX4L5 DN 3-(trifluoromethyl)-9H-carbazole DMWX4L5 MI TTBGTCW DMWX4L5 MN Kinesin spindle messenger RNA (KIF11 mRNA) DMWX4L5 MT DTT DMWX4L5 MA Inhibitor DMWX4L5 RN Kinesin spindle protein (KSP) inhibitors with 2,3-fused indole scaffolds. J Med Chem. 2010 Jul 8;53(13):5054-8. DMWX4L5 RU https://pubmed.ncbi.nlm.nih.gov/20521839 DM2YVA1 DI DM2YVA1 DM2YVA1 DN 3-(trifluoromethyl)benzaldehyde thiosemicarbazone DM2YVA1 MI TTEAID7 DM2YVA1 MN Trypanosoma Cruzipain (Trypano CYSP) DM2YVA1 MT DTT DM2YVA1 MA Inhibitor DM2YVA1 RN Synthesis and structure-activity relationship study of potent trypanocidal thio semicarbazone inhibitors of the trypanosomal cysteine protease cruz... J Med Chem. 2002 Jun 20;45(13):2695-707. DM2YVA1 RU https://pubmed.ncbi.nlm.nih.gov/12061873 DMH7K0N DI DMH7K0N DMH7K0N DN 3-(trifluoromethyl)phenyl 4-butoxybenzylcarbamate DMH7K0N MI TTDP1UC DMH7K0N MN Fatty acid amide hydrolase (FAAH) DMH7K0N MT DTT DMH7K0N MA Inhibitor DMH7K0N RN Oxime carbamate--discovery of a series of novel FAAH inhibitors. Bioorg Med Chem Lett. 2010 Feb 1;20(3):1272-7. DMH7K0N RU https://pubmed.ncbi.nlm.nih.gov/20036536 DM4B5JY DI DM4B5JY DM4B5JY DN 3-(trifluoromethyl)phenylboronic acid DM4B5JY MI TTDP1UC DM4B5JY MN Fatty acid amide hydrolase (FAAH) DM4B5JY MT DTT DM4B5JY MA Inhibitor DM4B5JY RN Discovery of boronic acids as novel and potent inhibitors of fatty acid amide hydrolase. J Med Chem. 2008 Nov 27;51(22):7057-60. DM4B5JY RU https://pubmed.ncbi.nlm.nih.gov/18983140 DMR9WF7 DI DMR9WF7 DMR9WF7 DN 3,14-DIDEHYDROGINKGOLIDE A DMR9WF7 MI TTZ8EM9 DMR9WF7 MN Glycine receptor (GlyR) DMR9WF7 MT DTT DMR9WF7 MA Inhibitor DMR9WF7 RN Probing the pharmacophore of ginkgolides as glycine receptor antagonists. J Med Chem. 2007 Apr 5;50(7):1610-7. DMR9WF7 RU https://pubmed.ncbi.nlm.nih.gov/17352465 DMR9WF7 DI DMR9WF7 DMR9WF7 DN 3,14-DIDEHYDROGINKGOLIDE A DMR9WF7 MI TTF45NW DMR9WF7 MN Strychnine-binding glycine receptor (GLRA1) DMR9WF7 MT DTT DMR9WF7 MA Inhibitor DMR9WF7 RN Probing the pharmacophore of ginkgolides as glycine receptor antagonists. J Med Chem. 2007 Apr 5;50(7):1610-7. DMR9WF7 RU https://pubmed.ncbi.nlm.nih.gov/17352465 DMD0Z3U DI DMD0Z3U DMD0Z3U DN 3,2'-bis-trifluoromethyl-biphenyl-4-carbonitrile DMD0Z3U MI TTKPW01 DMD0Z3U MN Androgen receptor messenger RNA (AR mRNA) DMD0Z3U MT DTT DMD0Z3U MA Inhibitor DMD0Z3U RN Preparation of 4-aryl-2-trifluoromethylbenzonitrile derivatives as androgen receptor antagonists for topical suppression of sebum production. Bioorg Med Chem Lett. 2007 Oct 15;17(20):5529-32. DMD0Z3U RU https://pubmed.ncbi.nlm.nih.gov/17764935 DM9GO8Y DI DM9GO8Y DM9GO8Y DN 3,3'-(1,2,4,5-tetrazine-3,6-diyl)diphenol DM9GO8Y MI TTIWB6L DM9GO8Y MN Estradiol 17 beta-dehydrogenase 1 (17-beta-HSD1) DM9GO8Y MT DTT DM9GO8Y MA Inhibitor DM9GO8Y RN Design, synthesis, biological evaluation and pharmacokinetics of bis(hydroxyphenyl) substituted azoles, thiophenes, benzenes, and aza-benzenes as p... J Med Chem. 2008 Nov 13;51(21):6725-39. DM9GO8Y RU https://pubmed.ncbi.nlm.nih.gov/18855374 DM4O2VC DI DM4O2VC DM4O2VC DN 3,3'-(1,2,4-Thiadiazol-2,5-diyl)diphenol DM4O2VC MI TTIWB6L DM4O2VC MN Estradiol 17 beta-dehydrogenase 1 (17-beta-HSD1) DM4O2VC MT DTT DM4O2VC MA Inhibitor DM4O2VC RN Design, synthesis, biological evaluation and pharmacokinetics of bis(hydroxyphenyl) substituted azoles, thiophenes, benzenes, and aza-benzenes as p... J Med Chem. 2008 Nov 13;51(21):6725-39. DM4O2VC RU https://pubmed.ncbi.nlm.nih.gov/18855374 DMC34UW DI DMC34UW DMC34UW DN 3,3'-(1,2,4-thiadiazole-3,5-diyl)diphenol DMC34UW MI TTIWB6L DMC34UW MN Estradiol 17 beta-dehydrogenase 1 (17-beta-HSD1) DMC34UW MT DTT DMC34UW MA Inhibitor DMC34UW RN Design, synthesis, biological evaluation and pharmacokinetics of bis(hydroxyphenyl) substituted azoles, thiophenes, benzenes, and aza-benzenes as p... J Med Chem. 2008 Nov 13;51(21):6725-39. DMC34UW RU https://pubmed.ncbi.nlm.nih.gov/18855374 DM9AJNW DI DM9AJNW DM9AJNW DN 3,3'-(1,3-Thiazol-2,4-diyl)diphenol DM9AJNW MI TTIWB6L DM9AJNW MN Estradiol 17 beta-dehydrogenase 1 (17-beta-HSD1) DM9AJNW MT DTT DM9AJNW MA Inhibitor DM9AJNW RN Design, synthesis, biological evaluation and pharmacokinetics of bis(hydroxyphenyl) substituted azoles, thiophenes, benzenes, and aza-benzenes as p... J Med Chem. 2008 Nov 13;51(21):6725-39. DM9AJNW RU https://pubmed.ncbi.nlm.nih.gov/18855374 DMQY50A DI DMQY50A DMQY50A DN 3,3-(1,3-Thiazole-2,5-diyl)diphenol DMQY50A MI TTXV4FI DMQY50A MN Albendazole monooxygenase (CYP3A4) DMQY50A MT DTT DMQY50A MA Inhibitor DMQY50A RN Design, synthesis, biological evaluation and pharmacokinetics of bis(hydroxyphenyl) substituted azoles, thiophenes, benzenes, and aza-benzenes as p... J Med Chem. 2008 Nov 13;51(21):6725-39. DMQY50A RU https://pubmed.ncbi.nlm.nih.gov/18855374 DMQY50A DI DMQY50A DMQY50A DN 3,3-(1,3-Thiazole-2,5-diyl)diphenol DMQY50A MI TTIWB6L DMQY50A MN Estradiol 17 beta-dehydrogenase 1 (17-beta-HSD1) DMQY50A MT DTT DMQY50A MA Inhibitor DMQY50A RN Design, synthesis, biological evaluation and pharmacokinetics of bis(hydroxyphenyl) substituted azoles, thiophenes, benzenes, and aza-benzenes as p... J Med Chem. 2008 Nov 13;51(21):6725-39. DMQY50A RU https://pubmed.ncbi.nlm.nih.gov/18855374 DM40SNY DI DM40SNY DM40SNY DN 3,3'-(3-Methylthiene-2,5-diyl]diphenol DM40SNY MI TTIWB6L DM40SNY MN Estradiol 17 beta-dehydrogenase 1 (17-beta-HSD1) DM40SNY MT DTT DM40SNY MA Inhibitor DM40SNY RN New insights into the SAR and binding modes of bis(hydroxyphenyl)thiophenes and -benzenes: influence of additional substituents on 17beta-hydroxyst... J Med Chem. 2009 Nov 12;52(21):6724-43. DM40SNY RU https://pubmed.ncbi.nlm.nih.gov/19831396 DMUK1VX DI DMUK1VX DMUK1VX DN 3,3'-(3-Phenylthiene-2,5-diyl)diphenol DMUK1VX MI TTIWB6L DMUK1VX MN Estradiol 17 beta-dehydrogenase 1 (17-beta-HSD1) DMUK1VX MT DTT DMUK1VX MA Inhibitor DMUK1VX RN New insights into the SAR and binding modes of bis(hydroxyphenyl)thiophenes and -benzenes: influence of additional substituents on 17beta-hydroxyst... J Med Chem. 2009 Nov 12;52(21):6724-43. DMUK1VX RU https://pubmed.ncbi.nlm.nih.gov/19831396 DMJVKMO DI DMJVKMO DMJVKMO DN 3,3'-(4-phenylpyridine-2,6-diyl)diphenol DMJVKMO MI TTGTQHC DMJVKMO MN DNA topoisomerase I (TOP1) DMJVKMO MT DTT DMJVKMO MA Inhibitor DMJVKMO RN Synthesis, topoisomerase I and II inhibitory activity, cytotoxicity, and structure-activity relationship study of hydroxylated 2,4-diphenyl-6-aryl ... Bioorg Med Chem. 2010 May 1;18(9):3066-77. DMJVKMO RU https://pubmed.ncbi.nlm.nih.gov/20392646 DMJVKMO DI DMJVKMO DMJVKMO DN 3,3'-(4-phenylpyridine-2,6-diyl)diphenol DMJVKMO MI TT0IHXV DMJVKMO MN DNA topoisomerase II (TOP2) DMJVKMO MT DTT DMJVKMO MA Inhibitor DMJVKMO RN Synthesis, topoisomerase I and II inhibitory activity, cytotoxicity, and structure-activity relationship study of hydroxylated 2,4-diphenyl-6-aryl ... Bioorg Med Chem. 2010 May 1;18(9):3066-77. DMJVKMO RU https://pubmed.ncbi.nlm.nih.gov/20392646 DMH7A32 DI DMH7A32 DMH7A32 DN 3,3',3''-Thiene-2,3,5-triyltriphenol DMH7A32 MI TTIWB6L DMH7A32 MN Estradiol 17 beta-dehydrogenase 1 (17-beta-HSD1) DMH7A32 MT DTT DMH7A32 MA Inhibitor DMH7A32 RN New insights into the SAR and binding modes of bis(hydroxyphenyl)thiophenes and -benzenes: influence of additional substituents on 17beta-hydroxyst... J Med Chem. 2009 Nov 12;52(21):6724-43. DMH7A32 RU https://pubmed.ncbi.nlm.nih.gov/19831396 DMBFY4H DI DMBFY4H DMBFY4H DN 3,3,3-tris(4-chlorophenyl)propanoic acid DMBFY4H MI TT6804T DMBFY4H MN MIF messenger RNA (MIF mRNA) DMBFY4H MT DTT DMBFY4H MA Inhibitor DMBFY4H RN Classification of chemical compounds by protein-compound docking for use in designing a focused library. J Med Chem. 2006 Jan 26;49(2):523-33. DMBFY4H RU https://pubmed.ncbi.nlm.nih.gov/16420039 DMO51QG DI DMO51QG DMO51QG DN 3,3-Bis-(4-hydroxy-phenyl)-2-phenyl-acrylonitrile DMO51QG MI TTFJ8Q1 DMO51QG MN Protein kinase C alpha (PRKCA) DMO51QG MT DTT DMO51QG MA Inhibitor DMO51QG RN Multivariate analysis by the minimum spanning tree method of the structural determinants of diphenylethylenes and triphenylacrylonitriles implicate... J Med Chem. 1992 Feb 7;35(3):573-83. DMO51QG RU https://pubmed.ncbi.nlm.nih.gov/1738150 DMO51QG DI DMO51QG DMO51QG DN 3,3-Bis-(4-hydroxy-phenyl)-2-phenyl-acrylonitrile DMO51QG MI TTYPXQF DMO51QG MN Protein kinase C beta (PRKCB) DMO51QG MT DTT DMO51QG MA Inhibitor DMO51QG RN Multivariate analysis by the minimum spanning tree method of the structural determinants of diphenylethylenes and triphenylacrylonitriles implicate... J Med Chem. 1992 Feb 7;35(3):573-83. DMO51QG RU https://pubmed.ncbi.nlm.nih.gov/1738150 DMO51QG DI DMO51QG DMO51QG DN 3,3-Bis-(4-hydroxy-phenyl)-2-phenyl-acrylonitrile DMO51QG MI TT9WJ8U DMO51QG MN Protein kinase C delta (PRKCD) DMO51QG MT DTT DMO51QG MA Inhibitor DMO51QG RN Multivariate analysis by the minimum spanning tree method of the structural determinants of diphenylethylenes and triphenylacrylonitriles implicate... J Med Chem. 1992 Feb 7;35(3):573-83. DMO51QG RU https://pubmed.ncbi.nlm.nih.gov/1738150 DMO51QG DI DMO51QG DMO51QG DN 3,3-Bis-(4-hydroxy-phenyl)-2-phenyl-acrylonitrile DMO51QG MI TTBZ7OD DMO51QG MN Protein kinase C epsilon (PRKCE) DMO51QG MT DTT DMO51QG MA Inhibitor DMO51QG RN Multivariate analysis by the minimum spanning tree method of the structural determinants of diphenylethylenes and triphenylacrylonitriles implicate... J Med Chem. 1992 Feb 7;35(3):573-83. DMO51QG RU https://pubmed.ncbi.nlm.nih.gov/1738150 DMO51QG DI DMO51QG DMO51QG DN 3,3-Bis-(4-hydroxy-phenyl)-2-phenyl-acrylonitrile DMO51QG MI TTRFOXJ DMO51QG MN Protein kinase C gamma (PRKCG) DMO51QG MT DTT DMO51QG MA Inhibitor DMO51QG RN Multivariate analysis by the minimum spanning tree method of the structural determinants of diphenylethylenes and triphenylacrylonitriles implicate... J Med Chem. 1992 Feb 7;35(3):573-83. DMO51QG RU https://pubmed.ncbi.nlm.nih.gov/1738150 DMO51QG DI DMO51QG DMO51QG DN 3,3-Bis-(4-hydroxy-phenyl)-2-phenyl-acrylonitrile DMO51QG MI TT8QL1J DMO51QG MN Protein kinase C theta (PRKCQ) DMO51QG MT DTT DMO51QG MA Inhibitor DMO51QG RN Multivariate analysis by the minimum spanning tree method of the structural determinants of diphenylethylenes and triphenylacrylonitriles implicate... J Med Chem. 1992 Feb 7;35(3):573-83. DMO51QG RU https://pubmed.ncbi.nlm.nih.gov/1738150 DMO51QG DI DMO51QG DMO51QG DN 3,3-Bis-(4-hydroxy-phenyl)-2-phenyl-acrylonitrile DMO51QG MI TTUWGRA DMO51QG MN Protein kinase C zeta (PRKCZ) DMO51QG MT DTT DMO51QG MA Inhibitor DMO51QG RN Multivariate analysis by the minimum spanning tree method of the structural determinants of diphenylethylenes and triphenylacrylonitriles implicate... J Med Chem. 1992 Feb 7;35(3):573-83. DMO51QG RU https://pubmed.ncbi.nlm.nih.gov/1738150 DMZPYN2 DI DMZPYN2 DMZPYN2 DN 3,3-Bis-(4-methoxy-phenyl)-2-phenyl-acrylonitrile DMZPYN2 MI TTFJ8Q1 DMZPYN2 MN Protein kinase C alpha (PRKCA) DMZPYN2 MT DTT DMZPYN2 MA Inhibitor DMZPYN2 RN Multivariate analysis by the minimum spanning tree method of the structural determinants of diphenylethylenes and triphenylacrylonitriles implicate... J Med Chem. 1992 Feb 7;35(3):573-83. DMZPYN2 RU https://pubmed.ncbi.nlm.nih.gov/1738150 DMZPYN2 DI DMZPYN2 DMZPYN2 DN 3,3-Bis-(4-methoxy-phenyl)-2-phenyl-acrylonitrile DMZPYN2 MI TTYPXQF DMZPYN2 MN Protein kinase C beta (PRKCB) DMZPYN2 MT DTT DMZPYN2 MA Inhibitor DMZPYN2 RN Multivariate analysis by the minimum spanning tree method of the structural determinants of diphenylethylenes and triphenylacrylonitriles implicate... J Med Chem. 1992 Feb 7;35(3):573-83. DMZPYN2 RU https://pubmed.ncbi.nlm.nih.gov/1738150 DMZPYN2 DI DMZPYN2 DMZPYN2 DN 3,3-Bis-(4-methoxy-phenyl)-2-phenyl-acrylonitrile DMZPYN2 MI TT9WJ8U DMZPYN2 MN Protein kinase C delta (PRKCD) DMZPYN2 MT DTT DMZPYN2 MA Inhibitor DMZPYN2 RN Multivariate analysis by the minimum spanning tree method of the structural determinants of diphenylethylenes and triphenylacrylonitriles implicate... J Med Chem. 1992 Feb 7;35(3):573-83. DMZPYN2 RU https://pubmed.ncbi.nlm.nih.gov/1738150 DMZPYN2 DI DMZPYN2 DMZPYN2 DN 3,3-Bis-(4-methoxy-phenyl)-2-phenyl-acrylonitrile DMZPYN2 MI TTBZ7OD DMZPYN2 MN Protein kinase C epsilon (PRKCE) DMZPYN2 MT DTT DMZPYN2 MA Inhibitor DMZPYN2 RN Multivariate analysis by the minimum spanning tree method of the structural determinants of diphenylethylenes and triphenylacrylonitriles implicate... J Med Chem. 1992 Feb 7;35(3):573-83. DMZPYN2 RU https://pubmed.ncbi.nlm.nih.gov/1738150 DMZPYN2 DI DMZPYN2 DMZPYN2 DN 3,3-Bis-(4-methoxy-phenyl)-2-phenyl-acrylonitrile DMZPYN2 MI TTRFOXJ DMZPYN2 MN Protein kinase C gamma (PRKCG) DMZPYN2 MT DTT DMZPYN2 MA Inhibitor DMZPYN2 RN Multivariate analysis by the minimum spanning tree method of the structural determinants of diphenylethylenes and triphenylacrylonitriles implicate... J Med Chem. 1992 Feb 7;35(3):573-83. DMZPYN2 RU https://pubmed.ncbi.nlm.nih.gov/1738150 DMZPYN2 DI DMZPYN2 DMZPYN2 DN 3,3-Bis-(4-methoxy-phenyl)-2-phenyl-acrylonitrile DMZPYN2 MI TT8QL1J DMZPYN2 MN Protein kinase C theta (PRKCQ) DMZPYN2 MT DTT DMZPYN2 MA Inhibitor DMZPYN2 RN Multivariate analysis by the minimum spanning tree method of the structural determinants of diphenylethylenes and triphenylacrylonitriles implicate... J Med Chem. 1992 Feb 7;35(3):573-83. DMZPYN2 RU https://pubmed.ncbi.nlm.nih.gov/1738150 DMZPYN2 DI DMZPYN2 DMZPYN2 DN 3,3-Bis-(4-methoxy-phenyl)-2-phenyl-acrylonitrile DMZPYN2 MI TTUWGRA DMZPYN2 MN Protein kinase C zeta (PRKCZ) DMZPYN2 MT DTT DMZPYN2 MA Inhibitor DMZPYN2 RN Multivariate analysis by the minimum spanning tree method of the structural determinants of diphenylethylenes and triphenylacrylonitriles implicate... J Med Chem. 1992 Feb 7;35(3):573-83. DMZPYN2 RU https://pubmed.ncbi.nlm.nih.gov/1738150 DMK9BN0 DI DMK9BN0 DMK9BN0 DN 3,3-di(pent-4-enyl)azetidin-2-one DMK9BN0 MI TTDP1UC DMK9BN0 MN Fatty acid amide hydrolase (FAAH) DMK9BN0 MT DTT DMK9BN0 MA Inhibitor DMK9BN0 RN 3-Alkenyl-2-azetidinones as fatty acid amide hydrolase inhibitors. Bioorg Med Chem Lett. 2008 Jul 15;18(14):4163-7. DMK9BN0 RU https://pubmed.ncbi.nlm.nih.gov/18547805 DMWFD5C DI DMWFD5C DMWFD5C DN 3,3-Diethyl-1-(pyridin-3-yl)azetidine-2,4-dione DMWFD5C MI TTPLTSQ DMWFD5C MN Neutrophil elastase (NE) DMWFD5C MT DTT DMWFD5C MA Inhibitor DMWFD5C RN 4-Oxo-beta-lactams (azetidine-2,4-diones) are potent and selective inhibitors of human leukocyte elastase. J Med Chem. 2010 Jan 14;53(1):241-53. DMWFD5C RU https://pubmed.ncbi.nlm.nih.gov/19904934 DMY8S94 DI DMY8S94 DMY8S94 DN 3,3-Diethyl-1-o-tolylazetidine-2,4-dione DMY8S94 MI TTPLTSQ DMY8S94 MN Neutrophil elastase (NE) DMY8S94 MT DTT DMY8S94 MA Inhibitor DMY8S94 RN 4-Oxo-beta-lactams (azetidine-2,4-diones) are potent and selective inhibitors of human leukocyte elastase. J Med Chem. 2010 Jan 14;53(1):241-53. DMY8S94 RU https://pubmed.ncbi.nlm.nih.gov/19904934 DMCFJIP DI DMCFJIP DMCFJIP DN 3,3-diethyl-1-phenylazetidine-2,4-dione DMCFJIP MI TTPLTSQ DMCFJIP MN Neutrophil elastase (NE) DMCFJIP MT DTT DMCFJIP MA Inhibitor DMCFJIP RN 4-Oxo-beta-lactams (azetidine-2,4-diones) are potent and selective inhibitors of human leukocyte elastase. J Med Chem. 2010 Jan 14;53(1):241-53. DMCFJIP RU https://pubmed.ncbi.nlm.nih.gov/19904934 DMFJ9N0 DI DMFJ9N0 DMFJ9N0 DN 3,3-Diethyl-dihydro-furan-2-one DMFJ9N0 MI TT1MPAY DMFJ9N0 MN GABA(A) receptor alpha-1 (GABRA1) DMFJ9N0 MT DTT DMFJ9N0 MA Inhibitor DMFJ9N0 RN Alpha-spirocyclopentyl- and alpha-spirocyclopropyl-gamma-butyrolactones: conformationally constrained derivatives of anticonvulsant and convulsant ... J Med Chem. 1994 Jan 21;37(2):275-86. DMFJ9N0 RU https://pubmed.ncbi.nlm.nih.gov/8295215 DMFJ9N0 DI DMFJ9N0 DMFJ9N0 DN 3,3-Diethyl-dihydro-furan-2-one DMFJ9N0 MI TTZA1NY DMFJ9N0 MN GABA(A) receptor beta-2 (GABRB2) DMFJ9N0 MT DTT DMFJ9N0 MA Inhibitor DMFJ9N0 RN Alpha-spirocyclopentyl- and alpha-spirocyclopropyl-gamma-butyrolactones: conformationally constrained derivatives of anticonvulsant and convulsant ... J Med Chem. 1994 Jan 21;37(2):275-86. DMFJ9N0 RU https://pubmed.ncbi.nlm.nih.gov/8295215 DMFJ9N0 DI DMFJ9N0 DMFJ9N0 DN 3,3-Diethyl-dihydro-furan-2-one DMFJ9N0 MI TT06RH5 DMFJ9N0 MN GABA(A) receptor gamma-2 (GABRG2) DMFJ9N0 MT DTT DMFJ9N0 MA Inhibitor DMFJ9N0 RN Alpha-spirocyclopentyl- and alpha-spirocyclopropyl-gamma-butyrolactones: conformationally constrained derivatives of anticonvulsant and convulsant ... J Med Chem. 1994 Jan 21;37(2):275-86. DMFJ9N0 RU https://pubmed.ncbi.nlm.nih.gov/8295215 DMFJ9N0 DI DMFJ9N0 DMFJ9N0 DN 3,3-Diethyl-dihydro-furan-2-one DMFJ9N0 MI TTNJYV2 DMFJ9N0 MN Gamma-aminobutyric acid receptor (GAR) DMFJ9N0 MT DTT DMFJ9N0 MA Inhibitor DMFJ9N0 RN Alpha-spirocyclopentyl- and alpha-spirocyclopropyl-gamma-butyrolactones: conformationally constrained derivatives of anticonvulsant and convulsant ... J Med Chem. 1994 Jan 21;37(2):275-86. DMFJ9N0 RU https://pubmed.ncbi.nlm.nih.gov/8295215 DMGMJWL DI DMGMJWL DMGMJWL DN 3,3'-difluorobenzaldazine DMGMJWL MI TTHS256 DMGMJWL MN Metabotropic glutamate receptor 5 (mGluR5) DMGMJWL MT DTT DMGMJWL MA Modulator (allosteric modulator) DMGMJWL RN A family of highly selective allosteric modulators of the metabotropic glutamate receptor subtype 5. Mol Pharmacol. 2003 Sep;64(3):731-40. DMGMJWL RU https://pubmed.ncbi.nlm.nih.gov/12920211 DMIFUDG DI DMIFUDG DMIFUDG DN 3,3-Diisopropyl-dihydro-furan-2-one DMIFUDG MI TT1MPAY DMIFUDG MN GABA(A) receptor alpha-1 (GABRA1) DMIFUDG MT DTT DMIFUDG MA Inhibitor DMIFUDG RN Alpha-spirocyclopentyl- and alpha-spirocyclopropyl-gamma-butyrolactones: conformationally constrained derivatives of anticonvulsant and convulsant ... J Med Chem. 1994 Jan 21;37(2):275-86. DMIFUDG RU https://pubmed.ncbi.nlm.nih.gov/8295215 DMIFUDG DI DMIFUDG DMIFUDG DN 3,3-Diisopropyl-dihydro-furan-2-one DMIFUDG MI TTZA1NY DMIFUDG MN GABA(A) receptor beta-2 (GABRB2) DMIFUDG MT DTT DMIFUDG MA Inhibitor DMIFUDG RN Alpha-spirocyclopentyl- and alpha-spirocyclopropyl-gamma-butyrolactones: conformationally constrained derivatives of anticonvulsant and convulsant ... J Med Chem. 1994 Jan 21;37(2):275-86. DMIFUDG RU https://pubmed.ncbi.nlm.nih.gov/8295215 DMIFUDG DI DMIFUDG DMIFUDG DN 3,3-Diisopropyl-dihydro-furan-2-one DMIFUDG MI TT06RH5 DMIFUDG MN GABA(A) receptor gamma-2 (GABRG2) DMIFUDG MT DTT DMIFUDG MA Inhibitor DMIFUDG RN Alpha-spirocyclopentyl- and alpha-spirocyclopropyl-gamma-butyrolactones: conformationally constrained derivatives of anticonvulsant and convulsant ... J Med Chem. 1994 Jan 21;37(2):275-86. DMIFUDG RU https://pubmed.ncbi.nlm.nih.gov/8295215 DMIFUDG DI DMIFUDG DMIFUDG DN 3,3-Diisopropyl-dihydro-furan-2-one DMIFUDG MI TTNJYV2 DMIFUDG MN Gamma-aminobutyric acid receptor (GAR) DMIFUDG MT DTT DMIFUDG MA Inhibitor DMIFUDG RN Alpha-spirocyclopentyl- and alpha-spirocyclopropyl-gamma-butyrolactones: conformationally constrained derivatives of anticonvulsant and convulsant ... J Med Chem. 1994 Jan 21;37(2):275-86. DMIFUDG RU https://pubmed.ncbi.nlm.nih.gov/8295215 DMUS0A4 DI DMUS0A4 DMUS0A4 DN 3,3-dimethyl-5-m-tolyl-2,3-dihydro-1H-inden-1-one DMUS0A4 MI TTUV8G9 DMUS0A4 MN Progesterone receptor (PGR) DMUS0A4 MT DTT DMUS0A4 MA Inhibitor DMUS0A4 RN 5-Aryl indanones and derivatives as non-steroidal progesterone receptor modulators. Bioorg Med Chem Lett. 2009 Dec 1;19(23):6666-9. DMUS0A4 RU https://pubmed.ncbi.nlm.nih.gov/19864132 DM09LY4 DI DM09LY4 DM09LY4 DN 3,3-Dimethyl-dihydro-furan-2-one DM09LY4 MI TTNJYV2 DM09LY4 MN Gamma-aminobutyric acid receptor (GAR) DM09LY4 MT DTT DM09LY4 MA Inhibitor DM09LY4 RN Alpha-spirocyclopentyl- and alpha-spirocyclopropyl-gamma-butyrolactones: conformationally constrained derivatives of anticonvulsant and convulsant ... J Med Chem. 1994 Jan 21;37(2):275-86. DM09LY4 RU https://pubmed.ncbi.nlm.nih.gov/8295215 DMNOUSV DI DMNOUSV DMNOUSV DN 3,3-diphenylpropan-1-amine DMNOUSV MI TTTIBOJ DMNOUSV MN Histamine H1 receptor (H1R) DMNOUSV MT DTT DMNOUSV MA Inhibitor DMNOUSV RN Synthesis, structure-affinity relationships, and modeling of AMDA analogs at 5-HT2A and H1 receptors: structural factors contributing to selectivity. Bioorg Med Chem. 2009 Sep 15;17(18):6496-504. DMNOUSV RU https://pubmed.ncbi.nlm.nih.gov/19700330 DMZTIPJ DI DMZTIPJ DMZTIPJ DN 3,3'-pyrazine-2,5-diyldiphenol DMZTIPJ MI TTIWB6L DMZTIPJ MN Estradiol 17 beta-dehydrogenase 1 (17-beta-HSD1) DMZTIPJ MT DTT DMZTIPJ MA Inhibitor DMZTIPJ RN Design, synthesis, biological evaluation and pharmacokinetics of bis(hydroxyphenyl) substituted azoles, thiophenes, benzenes, and aza-benzenes as p... J Med Chem. 2008 Nov 13;51(21):6725-39. DMZTIPJ RU https://pubmed.ncbi.nlm.nih.gov/18855374 DMZILNC DI DMZILNC DMZILNC DN 3,3'-Pyridine-2,5-diyldiphenol DMZILNC MI TTIWB6L DMZILNC MN Estradiol 17 beta-dehydrogenase 1 (17-beta-HSD1) DMZILNC MT DTT DMZILNC MA Inhibitor DMZILNC RN Design, synthesis, biological evaluation and pharmacokinetics of bis(hydroxyphenyl) substituted azoles, thiophenes, benzenes, and aza-benzenes as p... J Med Chem. 2008 Nov 13;51(21):6725-39. DMZILNC RU https://pubmed.ncbi.nlm.nih.gov/18855374 DMW7XFQ DI DMW7XFQ DMW7XFQ DN 3,3'-Thiene-2,4-diyldiphenol DMW7XFQ MI TTIWB6L DMW7XFQ MN Estradiol 17 beta-dehydrogenase 1 (17-beta-HSD1) DMW7XFQ MT DTT DMW7XFQ MA Inhibitor DMW7XFQ RN Design, synthesis, biological evaluation and pharmacokinetics of bis(hydroxyphenyl) substituted azoles, thiophenes, benzenes, and aza-benzenes as p... J Med Chem. 2008 Nov 13;51(21):6725-39. DMW7XFQ RU https://pubmed.ncbi.nlm.nih.gov/18855374 DMWH0ER DI DMWH0ER DMWH0ER DN 3,3'-thiene-2,5-diyldiphenol DMWH0ER MI TTIWB6L DMWH0ER MN Estradiol 17 beta-dehydrogenase 1 (17-beta-HSD1) DMWH0ER MT DTT DMWH0ER MA Inhibitor DMWH0ER RN New insights into the SAR and binding modes of bis(hydroxyphenyl)thiophenes and -benzenes: influence of additional substituents on 17beta-hydroxyst... J Med Chem. 2009 Nov 12;52(21):6724-43. DMWH0ER RU https://pubmed.ncbi.nlm.nih.gov/19831396 DMQDKYI DI DMQDKYI DMQDKYI DN 3,4'-(1H-1,2,4-triazole-3,5-diyl)dipyridine DMQDKYI MI TT7RJY8 DMQDKYI MN Xanthine dehydrogenase/oxidase (XDH) DMQDKYI MT DTT DMQDKYI MA Inhibitor DMQDKYI RN Discovery of 3-(2-cyano-4-pyridyl)-5-(4-pyridyl)-1,2,4-triazole, FYX-051 - a xanthine oxidoreductase inhibitor for the treatment of hyperuricemia [... Bioorg Med Chem Lett. 2009 Nov 1;19(21):6225-9. DMQDKYI RU https://pubmed.ncbi.nlm.nih.gov/19783139 DMFM60H DI DMFM60H DMFM60H DN 3,4'-(Ethane-1,2-diyl)dibenzenamine DMFM60H MI TTSZLWK DMFM60H MN Aromatase (CYP19A1) DMFM60H MT DTT DMFM60H MA Inhibitor DMFM60H RN Design, synthesis, and biological evaluation of resveratrol analogues as aromatase and quinone reductase 2 inhibitors for chemoprevention of cancer. Bioorg Med Chem. 2010 Jul 15;18(14):5352-66. DMFM60H RU https://pubmed.ncbi.nlm.nih.gov/20558073 DMEN9T4 DI DMEN9T4 DMEN9T4 DN 3,4'-(thiophene-2,4-diyl)diphenol DMEN9T4 MI TTIWB6L DMEN9T4 MN Estradiol 17 beta-dehydrogenase 1 (17-beta-HSD1) DMEN9T4 MT DTT DMEN9T4 MA Inhibitor DMEN9T4 RN New insights into the SAR and binding modes of bis(hydroxyphenyl)thiophenes and -benzenes: influence of additional substituents on 17beta-hydroxyst... J Med Chem. 2009 Nov 12;52(21):6724-43. DMEN9T4 RU https://pubmed.ncbi.nlm.nih.gov/19831396 DMSN814 DI DMSN814 DMSN814 DN 3,4,4',5-tetramethoxy-(Z)-stilbene DMSN814 MI TTYFKSZ DMSN814 MN Tubulin beta (TUBB) DMSN814 MT DTT DMSN814 MA Inhibitor DMSN814 RN 2-amino and 2'-aminocombretastatin derivatives as potent antimitotic agents. J Med Chem. 2006 Oct 19;49(21):6412-5. DMSN814 RU https://pubmed.ncbi.nlm.nih.gov/17034147 DMSN814 DI DMSN814 DMSN814 DN 3,4,4',5-tetramethoxy-(Z)-stilbene DMSN814 MI TTJ2PTI DMSN814 MN Tubulin beta-2 chain (TUBB2) DMSN814 MT DTT DMSN814 MA Inhibitor DMSN814 RN 2-amino and 2'-aminocombretastatin derivatives as potent antimitotic agents. J Med Chem. 2006 Oct 19;49(21):6412-5. DMSN814 RU https://pubmed.ncbi.nlm.nih.gov/17034147 DMSV6K5 DI DMSV6K5 DMSV6K5 DN 3,4,5,6-Tetrachloro-[1,2]benzoquinone DMSV6K5 MI TT1RS9F DMSV6K5 MN Acetylcholinesterase (AChE) DMSV6K5 MT DTT DMSV6K5 MA Inhibitor DMSV6K5 RN Identification and characterization of novel benzil (diphenylethane-1,2-dione) analogues as inhibitors of mammalian carboxylesterases. J Med Chem. 2005 Apr 21;48(8):2906-15. DMSV6K5 RU https://pubmed.ncbi.nlm.nih.gov/15828829 DMSV6K5 DI DMSV6K5 DMSV6K5 DN 3,4,5,6-Tetrachloro-[1,2]benzoquinone DMSV6K5 MI TTEB0GD DMSV6K5 MN Cholinesterase (BCHE) DMSV6K5 MT DTT DMSV6K5 MA Inhibitor DMSV6K5 RN Identification and characterization of novel benzil (diphenylethane-1,2-dione) analogues as inhibitors of mammalian carboxylesterases. J Med Chem. 2005 Apr 21;48(8):2906-15. DMSV6K5 RU https://pubmed.ncbi.nlm.nih.gov/15828829 DMSV6K5 DI DMSV6K5 DMSV6K5 DN 3,4,5,6-Tetrachloro-[1,2]benzoquinone DMSV6K5 MI TTMF541 DMSV6K5 MN Liver carboxylesterase (CES1) DMSV6K5 MT DTT DMSV6K5 MA Inhibitor DMSV6K5 RN Identification and characterization of novel benzil (diphenylethane-1,2-dione) analogues as inhibitors of mammalian carboxylesterases. J Med Chem. 2005 Apr 21;48(8):2906-15. DMSV6K5 RU https://pubmed.ncbi.nlm.nih.gov/15828829 DMKOE9I DI DMKOE9I DMKOE9I DN 3,4,5,6-Tetrahydrobenzo[c]quinolizin-3-(4aH)-one DMKOE9I MI TTTU72V DMKOE9I MN Steroid 5-alpha-reductase 1 (SRD5A1) DMKOE9I MT DTT DMKOE9I MA Inhibitor DMKOE9I RN Benzo[c]quinolizin-3-ones: a novel class of potent and selective nonsteroidal inhibitors of human steroid 5alpha-reductase 1. J Med Chem. 2000 Oct 5;43(20):3718-35. DMKOE9I RU https://pubmed.ncbi.nlm.nih.gov/11020287 DMS42CA DI DMS42CA DMS42CA DN 3,4,5-tribromo-2-(2', 4'-dibromo-phenoxy)phenol DMS42CA MI TTCFP0V DMS42CA MN Glutamine amidotransferase (GMPS) DMS42CA MT DTT DMS42CA MA Inhibitor DMS42CA RN Enzyme inhibitors: new and known polybrominated phenols and diphenyl ethers from four Indo-Pacific Dysidea sponges. J Nat Prod. 1995 Sep;58(9):1384-91. DMS42CA RU https://pubmed.ncbi.nlm.nih.gov/7494145 DMYHC3S DI DMYHC3S DMYHC3S DN 3,4',5-trimethoxy-(Z)-stilbene DMYHC3S MI TTYFKSZ DMYHC3S MN Tubulin beta (TUBB) DMYHC3S MT DTT DMYHC3S MA Inhibitor DMYHC3S RN 2-amino and 2'-aminocombretastatin derivatives as potent antimitotic agents. J Med Chem. 2006 Oct 19;49(21):6412-5. DMYHC3S RU https://pubmed.ncbi.nlm.nih.gov/17034147 DMYHC3S DI DMYHC3S DMYHC3S DN 3,4',5-trimethoxy-(Z)-stilbene DMYHC3S MI TTJ2PTI DMYHC3S MN Tubulin beta-2 chain (TUBB2) DMYHC3S MT DTT DMYHC3S MA Inhibitor DMYHC3S RN 2-amino and 2'-aminocombretastatin derivatives as potent antimitotic agents. J Med Chem. 2006 Oct 19;49(21):6412-5. DMYHC3S RU https://pubmed.ncbi.nlm.nih.gov/17034147 DMCA7XU DI DMCA7XU DMCA7XU DN 3,4,5-Trimethoxy-3'-amino-trans-stilbene DMCA7XU MI TTSZLWK DMCA7XU MN Aromatase (CYP19A1) DMCA7XU MT DTT DMCA7XU MA Inhibitor DMCA7XU RN Design, synthesis, and biological evaluation of resveratrol analogues as aromatase and quinone reductase 2 inhibitors for chemoprevention of cancer. Bioorg Med Chem. 2010 Jul 15;18(14):5352-66. DMCA7XU RU https://pubmed.ncbi.nlm.nih.gov/20558073 DMDBOJ5 DI DMDBOJ5 DMDBOJ5 DN 3,4,5-Trimethoxy-4'-amino-trans-stilbene DMDBOJ5 MI TTSZLWK DMDBOJ5 MN Aromatase (CYP19A1) DMDBOJ5 MT DTT DMDBOJ5 MA Inhibitor DMDBOJ5 RN Design, synthesis, and biological evaluation of resveratrol analogues as aromatase and quinone reductase 2 inhibitors for chemoprevention of cancer. Bioorg Med Chem. 2010 Jul 15;18(14):5352-66. DMDBOJ5 RU https://pubmed.ncbi.nlm.nih.gov/20558073 DMDBOJ5 DI DMDBOJ5 DMDBOJ5 DN 3,4,5-Trimethoxy-4'-amino-trans-stilbene DMDBOJ5 MI TTJLP0R DMDBOJ5 MN Quinone reductase 2 (NQO2) DMDBOJ5 MT DTT DMDBOJ5 MA Inhibitor DMDBOJ5 RN Design, synthesis, and biological evaluation of resveratrol analogues as aromatase and quinone reductase 2 inhibitors for chemoprevention of cancer. Bioorg Med Chem. 2010 Jul 15;18(14):5352-66. DMDBOJ5 RU https://pubmed.ncbi.nlm.nih.gov/20558073 DMU5NRA DI DMU5NRA DMU5NRA DN 3,4,5-trimethoxy-N-(thiazol-2-yl)benzamide DMU5NRA MI TTSJ6Q4 DMU5NRA MN LOX-5 messenger RNA (ALOX5 mRNA) DMU5NRA MT DTT DMU5NRA MA Inhibitor DMU5NRA RN Identification of natural-product-derived inhibitors of 5-lipoxygenase activity by ligand-based virtual screening. J Med Chem. 2007 May 31;50(11):2640-6. DMU5NRA RU https://pubmed.ncbi.nlm.nih.gov/17461565 DMO34LJ DI DMO34LJ DMO34LJ DN 3,4,6-Tribromo-2-(2,4-dibromo-phenoxy)-phenol DMO34LJ MI TT12ABZ DMO34LJ MN Arachidonate 12-lipoxygenase (12-LOX) DMO34LJ MT DTT DMO34LJ MA Inhibitor DMO34LJ RN Probing the activity differences of simple and complex brominated aryl compounds against 15-soybean, 15-human, and 12-human lipoxygenase. J Med Chem. 2004 Jul 29;47(16):4060-5. DMO34LJ RU https://pubmed.ncbi.nlm.nih.gov/15267244 DMO34LJ DI DMO34LJ DMO34LJ DN 3,4,6-Tribromo-2-(2,4-dibromo-phenoxy)-phenol DMO34LJ MI TTN9T81 DMO34LJ MN Arachidonate 15-lipoxygenase (15-LOX) DMO34LJ MT DTT DMO34LJ MA Inhibitor DMO34LJ RN Probing the activity differences of simple and complex brominated aryl compounds against 15-soybean, 15-human, and 12-human lipoxygenase. J Med Chem. 2004 Jul 29;47(16):4060-5. DMO34LJ RU https://pubmed.ncbi.nlm.nih.gov/15267244 DM3MAEQ DI DM3MAEQ DM3MAEQ DN 3,4,6-Trihydroxy-2-(4-hydroxy-phenyl)-inden-1-one DM3MAEQ MI TTOM3J0 DM3MAEQ MN Estrogen receptor beta (ESR2) DM3MAEQ MT DTT DM3MAEQ MA Inhibitor DM3MAEQ RN Estrogen receptor ligands: design and synthesis of new 2-arylindene-1-ones. Bioorg Med Chem Lett. 2005 Jun 15;15(12):3137-42. DM3MAEQ RU https://pubmed.ncbi.nlm.nih.gov/15876535 DMN4Z27 DI DMN4Z27 DMN4Z27 DN 3,4-Benzo-7-(beta-bromoallyloxy)-8-methylcoumarin DMN4Z27 MI TT3WG5C DMN4Z27 MN Monoamine oxidase type A (MAO-A) DMN4Z27 MT DTT DMN4Z27 MA Inhibitor DMN4Z27 RN Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors. J Med Chem. 2008 Nov 13;51(21):6740-51. DMN4Z27 RU https://pubmed.ncbi.nlm.nih.gov/18834112 DMN4Z27 DI DMN4Z27 DMN4Z27 DN 3,4-Benzo-7-(beta-bromoallyloxy)-8-methylcoumarin DMN4Z27 MI TTGP7BY DMN4Z27 MN Monoamine oxidase type B (MAO-B) DMN4Z27 MT DTT DMN4Z27 MA Inhibitor DMN4Z27 RN Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors. J Med Chem. 2008 Nov 13;51(21):6740-51. DMN4Z27 RU https://pubmed.ncbi.nlm.nih.gov/18834112 DM1MC06 DI DM1MC06 DM1MC06 DN 3,4-Benzo-7-acetonyloxy-8-methoxycoumarin DM1MC06 MI TT3WG5C DM1MC06 MN Monoamine oxidase type A (MAO-A) DM1MC06 MT DTT DM1MC06 MA Inhibitor DM1MC06 RN Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors. J Med Chem. 2008 Nov 13;51(21):6740-51. DM1MC06 RU https://pubmed.ncbi.nlm.nih.gov/18834112 DM1MC06 DI DM1MC06 DM1MC06 DN 3,4-Benzo-7-acetonyloxy-8-methoxycoumarin DM1MC06 MI TTGP7BY DM1MC06 MN Monoamine oxidase type B (MAO-B) DM1MC06 MT DTT DM1MC06 MA Inhibitor DM1MC06 RN Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors. J Med Chem. 2008 Nov 13;51(21):6740-51. DM1MC06 RU https://pubmed.ncbi.nlm.nih.gov/18834112 DMKC6L8 DI DMKC6L8 DMKC6L8 DN 3,4-Benzo-7-acetonyloxy-8-methylcoumarin DMKC6L8 MI TT3WG5C DMKC6L8 MN Monoamine oxidase type A (MAO-A) DMKC6L8 MT DTT DMKC6L8 MA Inhibitor DMKC6L8 RN Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors. J Med Chem. 2008 Nov 13;51(21):6740-51. DMKC6L8 RU https://pubmed.ncbi.nlm.nih.gov/18834112 DM91W2K DI DM91W2K DM91W2K DN 3,4-bis(3,4-dimethoxyphenyl)furan-2(5H)-one DM91W2K MI TTSZLWK DM91W2K MN Aromatase (CYP19A1) DM91W2K MT DTT DM91W2K MA Inhibitor DM91W2K RN Pharmacophore modeling strategies for the development of novel nonsteroidal inhibitors of human aromatase (CYP19). Bioorg Med Chem Lett. 2010 May 15;20(10):3050-64. DM91W2K RU https://pubmed.ncbi.nlm.nih.gov/20413308 DMEQ1HC DI DMEQ1HC DMEQ1HC DN 3,4-bis(indol-3-yl)maleimide derivative DMEQ1HC MI TTH6V3D DMEQ1HC MN Cyclin-dependent kinase 1 (CDK1) DMEQ1HC MT DTT DMEQ1HC MA Inhibitor DMEQ1HC RN Design of new inhibitors for cdc2 kinase based on a multiple pseudosubstrate structure. Bioorg Med Chem Lett. 1998 May 5;8(9):1019-22. DMEQ1HC RU https://pubmed.ncbi.nlm.nih.gov/9871700 DMEQ1HC DI DMEQ1HC DMEQ1HC DN 3,4-bis(indol-3-yl)maleimide derivative DMEQ1HC MI TT9P6OW DMEQ1HC MN G2/mitotic-specific cyclin B1 (CCNB1) DMEQ1HC MT DTT DMEQ1HC MA Inhibitor DMEQ1HC RN Design of new inhibitors for cdc2 kinase based on a multiple pseudosubstrate structure. Bioorg Med Chem Lett. 1998 May 5;8(9):1019-22. DMEQ1HC RU https://pubmed.ncbi.nlm.nih.gov/9871700 DMDO175 DI DMDO175 DMDO175 DN 3,4-di-(4-methoxyphenyl)-1H-pyrrole-2,5-dione DMDO175 MI TT9VGXW DMDO175 MN Angiopoietin 1 receptor (TEK) DMDO175 MT DTT DMDO175 MA Inhibitor DMDO175 RN Design, synthesis, and biological evaluation of 3,4-diarylmaleimides as angiogenesis inhibitors. J Med Chem. 2006 Feb 23;49(4):1271-81. DMDO175 RU https://pubmed.ncbi.nlm.nih.gov/16480264 DMDO175 DI DMDO175 DMDO175 DN 3,4-di-(4-methoxyphenyl)-1H-pyrrole-2,5-dione DMDO175 MI TTH6V3D DMDO175 MN Cyclin-dependent kinase 1 (CDK1) DMDO175 MT DTT DMDO175 MA Inhibitor DMDO175 RN Design, synthesis, and biological evaluation of 3,4-diarylmaleimides as angiogenesis inhibitors. J Med Chem. 2006 Feb 23;49(4):1271-81. DMDO175 RU https://pubmed.ncbi.nlm.nih.gov/16480264 DMDO175 DI DMDO175 DMDO175 DN 3,4-di-(4-methoxyphenyl)-1H-pyrrole-2,5-dione DMDO175 MI TT7HF4W DMDO175 MN Cyclin-dependent kinase 2 (CDK2) DMDO175 MT DTT DMDO175 MA Inhibitor DMDO175 RN Design, synthesis, and biological evaluation of 3,4-diarylmaleimides as angiogenesis inhibitors. J Med Chem. 2006 Feb 23;49(4):1271-81. DMDO175 RU https://pubmed.ncbi.nlm.nih.gov/16480264 DMDO175 DI DMDO175 DMDO175 DN 3,4-di-(4-methoxyphenyl)-1H-pyrrole-2,5-dione DMDO175 MI TT0PG8F DMDO175 MN Cyclin-dependent kinase 4 (CDK4) DMDO175 MT DTT DMDO175 MA Inhibitor DMDO175 RN Design, synthesis, and biological evaluation of 3,4-diarylmaleimides as angiogenesis inhibitors. J Med Chem. 2006 Feb 23;49(4):1271-81. DMDO175 RU https://pubmed.ncbi.nlm.nih.gov/16480264 DMDO175 DI DMDO175 DMDO175 DN 3,4-di-(4-methoxyphenyl)-1H-pyrrole-2,5-dione DMDO175 MI TTO0FDJ DMDO175 MN Cyclin-dependent kinase 6 (CDK6) DMDO175 MT DTT DMDO175 MA Inhibitor DMDO175 RN Design, synthesis, and biological evaluation of 3,4-diarylmaleimides as angiogenesis inhibitors. J Med Chem. 2006 Feb 23;49(4):1271-81. DMDO175 RU https://pubmed.ncbi.nlm.nih.gov/16480264 DMDO175 DI DMDO175 DMDO175 DN 3,4-di-(4-methoxyphenyl)-1H-pyrrole-2,5-dione DMDO175 MI TTGKNB4 DMDO175 MN Epidermal growth factor receptor (EGFR) DMDO175 MT DTT DMDO175 MA Inhibitor DMDO175 RN Design, synthesis, and biological evaluation of 3,4-diarylmaleimides as angiogenesis inhibitors. J Med Chem. 2006 Feb 23;49(4):1271-81. DMDO175 RU https://pubmed.ncbi.nlm.nih.gov/16480264 DMDO175 DI DMDO175 DMDO175 DN 3,4-di-(4-methoxyphenyl)-1H-pyrrole-2,5-dione DMDO175 MI TTR5TV4 DMDO175 MN ERBB2 messenger RNA (HER2 mRNA) DMDO175 MT DTT DMDO175 MA Inhibitor DMDO175 RN Design, synthesis, and biological evaluation of 3,4-diarylmaleimides as angiogenesis inhibitors. J Med Chem. 2006 Feb 23;49(4):1271-81. DMDO175 RU https://pubmed.ncbi.nlm.nih.gov/16480264 DMDO175 DI DMDO175 DMDO175 DN 3,4-di-(4-methoxyphenyl)-1H-pyrrole-2,5-dione DMDO175 MI TTFCJ7S DMDO175 MN G1/S-specific cyclin-D1 (CCND1) DMDO175 MT DTT DMDO175 MA Inhibitor DMDO175 RN Design, synthesis, and biological evaluation of 3,4-diarylmaleimides as angiogenesis inhibitors. J Med Chem. 2006 Feb 23;49(4):1271-81. DMDO175 RU https://pubmed.ncbi.nlm.nih.gov/16480264 DMDO175 DI DMDO175 DMDO175 DN 3,4-di-(4-methoxyphenyl)-1H-pyrrole-2,5-dione DMDO175 MI TTCEJ4F DMDO175 MN G1/S-specific cyclin-E1 (CCNE1) DMDO175 MT DTT DMDO175 MA Inhibitor DMDO175 RN Design, synthesis, and biological evaluation of 3,4-diarylmaleimides as angiogenesis inhibitors. J Med Chem. 2006 Feb 23;49(4):1271-81. DMDO175 RU https://pubmed.ncbi.nlm.nih.gov/16480264 DMDO175 DI DMDO175 DMDO175 DN 3,4-di-(4-methoxyphenyl)-1H-pyrrole-2,5-dione DMDO175 MI TT9P6OW DMDO175 MN G2/mitotic-specific cyclin B1 (CCNB1) DMDO175 MT DTT DMDO175 MA Inhibitor DMDO175 RN Design, synthesis, and biological evaluation of 3,4-diarylmaleimides as angiogenesis inhibitors. J Med Chem. 2006 Feb 23;49(4):1271-81. DMDO175 RU https://pubmed.ncbi.nlm.nih.gov/16480264 DMDO175 DI DMDO175 DMDO175 DN 3,4-di-(4-methoxyphenyl)-1H-pyrrole-2,5-dione DMDO175 MI TTFJ8Q1 DMDO175 MN Protein kinase C alpha (PRKCA) DMDO175 MT DTT DMDO175 MA Inhibitor DMDO175 RN Design, synthesis, and biological evaluation of 3,4-diarylmaleimides as angiogenesis inhibitors. J Med Chem. 2006 Feb 23;49(4):1271-81. DMDO175 RU https://pubmed.ncbi.nlm.nih.gov/16480264 DMDO175 DI DMDO175 DMDO175 DN 3,4-di-(4-methoxyphenyl)-1H-pyrrole-2,5-dione DMDO175 MI TTBZ7OD DMDO175 MN Protein kinase C epsilon (PRKCE) DMDO175 MT DTT DMDO175 MA Inhibitor DMDO175 RN Design, synthesis, and biological evaluation of 3,4-diarylmaleimides as angiogenesis inhibitors. J Med Chem. 2006 Feb 23;49(4):1271-81. DMDO175 RU https://pubmed.ncbi.nlm.nih.gov/16480264 DMDO175 DI DMDO175 DMDO175 DN 3,4-di-(4-methoxyphenyl)-1H-pyrrole-2,5-dione DMDO175 MI TTRFOXJ DMDO175 MN Protein kinase C gamma (PRKCG) DMDO175 MT DTT DMDO175 MA Inhibitor DMDO175 RN Design, synthesis, and biological evaluation of 3,4-diarylmaleimides as angiogenesis inhibitors. J Med Chem. 2006 Feb 23;49(4):1271-81. DMDO175 RU https://pubmed.ncbi.nlm.nih.gov/16480264 DMDO175 DI DMDO175 DMDO175 DN 3,4-di-(4-methoxyphenyl)-1H-pyrrole-2,5-dione DMDO175 MI TTUTJGQ DMDO175 MN Vascular endothelial growth factor receptor 2 (KDR) DMDO175 MT DTT DMDO175 MA Inhibitor DMDO175 RN Design, synthesis, and biological evaluation of 3,4-diarylmaleimides as angiogenesis inhibitors. J Med Chem. 2006 Feb 23;49(4):1271-81. DMDO175 RU https://pubmed.ncbi.nlm.nih.gov/16480264 DM8R03D DI DM8R03D DM8R03D DN 3,4-diarylpyrazoline derivative DM8R03D MI TT6OEDT DM8R03D MN Cannabinoid receptor 1 (CB1) DM8R03D MT DTT DM8R03D MA Inhibitor DM8R03D RN Novel 3,4-diarylpyrazolines as potent cannabinoid CB1 receptor antagonists with lower lipophilicity. Bioorg Med Chem Lett. 2005 Nov 1;15(21):4794-8. DM8R03D RU https://pubmed.ncbi.nlm.nih.gov/16140010 DM8R03D DI DM8R03D DM8R03D DN 3,4-diarylpyrazoline derivative DM8R03D MI TTMSFAW DM8R03D MN Cannabinoid receptor 2 (CB2) DM8R03D MT DTT DM8R03D MA Inhibitor DM8R03D RN Novel 3,4-diarylpyrazolines as potent cannabinoid CB1 receptor antagonists with lower lipophilicity. Bioorg Med Chem Lett. 2005 Nov 1;15(21):4794-8. DM8R03D RU https://pubmed.ncbi.nlm.nih.gov/16140010 DMBUT8A DI DMBUT8A DMBUT8A DN 3,4-dibenzyloxy-2'-hydroxychalcone DMBUT8A MI TTVKILB DMBUT8A MN Prostaglandin G/H synthase 2 (COX-2) DMBUT8A MT DTT DMBUT8A MA Inhibitor DMBUT8A RN Inhibitory activity of prostaglandin E2 production by the synthetic 2'-hydroxychalcone analogues: Synthesis and SAR study. Bioorg Med Chem Lett. 2009 Mar 15;19(6):1650-3. DMBUT8A RU https://pubmed.ncbi.nlm.nih.gov/19233646 DMXQVRD DI DMXQVRD DMXQVRD DN 3,4-Dibromo-2-(5-bromo-2-hydroxy-phenoxy)-phenol DMXQVRD MI TTN9T81 DMXQVRD MN Arachidonate 15-lipoxygenase (15-LOX) DMXQVRD MT DTT DMXQVRD MA Inhibitor DMXQVRD RN Probing the activity differences of simple and complex brominated aryl compounds against 15-soybean, 15-human, and 12-human lipoxygenase. J Med Chem. 2004 Jul 29;47(16):4060-5. DMXQVRD RU https://pubmed.ncbi.nlm.nih.gov/15267244 DMS1QIJ DI DMS1QIJ DMS1QIJ DN 3',4'-dichloroacetophenonethiosemicarbazone DMS1QIJ MI TTEAID7 DMS1QIJ MN Trypanosoma Cruzipain (Trypano CYSP) DMS1QIJ MT DTT DMS1QIJ MA Inhibitor DMS1QIJ RN Studies toward the structural optimization of novel thiazolylhydrazone-based potent antitrypanosomal agents. Bioorg Med Chem. 2010 Nov 15;18(22):7826-35. DMS1QIJ RU https://pubmed.ncbi.nlm.nih.gov/20961766 DMUSPIC DI DMUSPIC DMUSPIC DN 3,4-dichlorobenzaldehyde thiosemicarbazone DMUSPIC MI TTEAID7 DMUSPIC MN Trypanosoma Cruzipain (Trypano CYSP) DMUSPIC MT DTT DMUSPIC MA Inhibitor DMUSPIC RN Synthesis and structure-activity relationship study of potent trypanocidal thio semicarbazone inhibitors of the trypanosomal cysteine protease cruz... J Med Chem. 2002 Jun 20;45(13):2695-707. DMUSPIC RU https://pubmed.ncbi.nlm.nih.gov/12061873 DMN61Q5 DI DMN61Q5 DMN61Q5 DN 3,4-Dichlorobenzenemethanethiol DMN61Q5 MI TTZJYKH DMN61Q5 MN Indoleamine 2,3-dioxygenase 1 (IDO1) DMN61Q5 MT DTT DMN61Q5 MA Inhibitor DMN61Q5 RN S-benzylisothiourea derivatives as small-molecule inhibitors of indoleamine-2,3-dioxygenase. Bioorg Med Chem Lett. 2010 Sep 1;20(17):5126-9. DMN61Q5 RU https://pubmed.ncbi.nlm.nih.gov/20688518 DMOZCDK DI DMOZCDK DMOZCDK DN 3,4-dichloroisocoumarin DMOZCDK MI TTPLTSQ DMOZCDK MN Neutrophil elastase (NE) DMOZCDK MT DTT DMOZCDK MA Inhibitor DMOZCDK RN Cathepsin A is the major hydrolase catalyzing the intracellular hydrolysis of the antiretroviral nucleotide phosphonoamidate prodrugs GS-7340 and G... Antimicrob Agents Chemother. 2007 Feb;51(2):543-50. DMOZCDK RU https://pubmed.ncbi.nlm.nih.gov/17145787 DMMZURL DI DMMZURL DMMZURL DN 3,4-Dichloro-N-(2-methyl-1H-indol-5-yl)benzamide DMMZURL MI TT3WG5C DMMZURL MN Monoamine oxidase type A (MAO-A) DMMZURL MT DTT DMMZURL MA Inhibitor DMMZURL RN Inhibition of monoamine oxidase by indole and benzofuran derivatives. Eur J Med Chem. 2010 Oct;45(10):4458-66. DMMZURL RU https://pubmed.ncbi.nlm.nih.gov/20674099 DMMZURL DI DMMZURL DMMZURL DN 3,4-Dichloro-N-(2-methyl-1H-indol-5-yl)benzamide DMMZURL MI TTGP7BY DMMZURL MN Monoamine oxidase type B (MAO-B) DMMZURL MT DTT DMMZURL MA Inhibitor DMMZURL RN Inhibition of monoamine oxidase by indole and benzofuran derivatives. Eur J Med Chem. 2010 Oct;45(10):4458-66. DMMZURL RU https://pubmed.ncbi.nlm.nih.gov/20674099 DMWOMVF DI DMWOMVF DMWOMVF DN 3,4-Dichloro-N-(3,3-diphenyl-allyl)-benzamide DMWOMVF MI TTCG0AL DMWOMVF MN Cholecystokinin receptor type A (CCKAR) DMWOMVF MT DTT DMWOMVF MA Inhibitor DMWOMVF RN Hybrid cholecystokinin-A antagonists based on molecular modeling of lorglumide and L-364,718. J Med Chem. 1992 Mar 20;35(6):1042-9. DMWOMVF RU https://pubmed.ncbi.nlm.nih.gov/1552499 DM4RNOE DI DM4RNOE DM4RNOE DN 3,4-Dichloro-N-(4-phenyl-thiazol-2-yl)-benzamide DM4RNOE MI TTK25J1 DM4RNOE MN Adenosine A1 receptor (ADORA1) DM4RNOE MT DTT DM4RNOE MA Inhibitor DM4RNOE RN Substituted 4-phenyl-2-(phenylcarboxamido)-1,3-thiazole derivatives as antagonists for the adenosine A(1) receptor. Bioorg Med Chem Lett. 2001 Aug 6;11(15):2017-9. DM4RNOE RU https://pubmed.ncbi.nlm.nih.gov/11454470 DMFV3Y9 DI DMFV3Y9 DMFV3Y9 DN 3,4-difluorobenzaldehyde O-benzoyloxime DMFV3Y9 MI TTDNFMT DMFV3Y9 MN Platelet-activating factor acetylhydrolase (PLA2G7) DMFV3Y9 MT DTT DMFV3Y9 MA Inhibitor DMFV3Y9 RN Potent inhibitors of lipoprotein-associated phospholipase A(2): benzaldehyde O-heterocycle-4-carbonyloxime. Bioorg Med Chem Lett. 2006 Nov 1;16(21):5576-9. DMFV3Y9 RU https://pubmed.ncbi.nlm.nih.gov/16919943 DM0I6UT DI DM0I6UT DM0I6UT DN 3,4-Dihydro-1H-quinolin-(2E)-ylideneamine DM0I6UT MI TTZUFI5 DM0I6UT MN Nitric-oxide synthase brain (NOS1) DM0I6UT MT DTT DM0I6UT MA Inhibitor DM0I6UT RN Bicyclic amidine inhibitors of nitric oxide synthase: discovery of perhydro-iminopyrindine and perhydro-iminoquinoline as potent, orally active inh... Bioorg Med Chem Lett. 2005 Apr 15;15(8):1997-2001. DM0I6UT RU https://pubmed.ncbi.nlm.nih.gov/15808455 DM0I6UT DI DM0I6UT DM0I6UT DN 3,4-Dihydro-1H-quinolin-(2E)-ylideneamine DM0I6UT MI TTF10I9 DM0I6UT MN Nitric-oxide synthase inducible (NOS2) DM0I6UT MT DTT DM0I6UT MA Inhibitor DM0I6UT RN Bicyclic amidine inhibitors of nitric oxide synthase: discovery of perhydro-iminopyrindine and perhydro-iminoquinoline as potent, orally active inh... Bioorg Med Chem Lett. 2005 Apr 15;15(8):1997-2001. DM0I6UT RU https://pubmed.ncbi.nlm.nih.gov/15808455 DMUOXHP DI DMUOXHP DMUOXHP DN 3,4-dihydroquinazolin-2-amine hydrobromide DMUOXHP MI TTRUFDT DMUOXHP MN 5-HT 5A receptor (HTR5A) DMUOXHP MT DTT DMUOXHP MA Inhibitor DMUOXHP RN Cyclic guanidines as dual 5-HT5A/5-HT7 receptor ligands: structure-activity relationship elucidation. Bioorg Med Chem Lett. 2008 Jan 1;18(1):256-61. DMUOXHP RU https://pubmed.ncbi.nlm.nih.gov/17998160 DMG4NR3 DI DMG4NR3 DMG4NR3 DN 3,4-Dihydroxy-10H-anthracen-9-one DMG4NR3 MI TT2J34L DMG4NR3 MN Arachidonate 5-lipoxygenase (5-LOX) DMG4NR3 MT DTT DMG4NR3 MA Inhibitor DMG4NR3 RN Simple analogues of anthralin: unusual specificity of structure and antiproliferative activity. J Med Chem. 1997 Nov 7;40(23):3773-80. DMG4NR3 RU https://pubmed.ncbi.nlm.nih.gov/9371243 DMZJ4VL DI DMZJ4VL DMZJ4VL DN 3,4-dihydroxybenzaldehyde-O-ethyloxime DMZJ4VL MI TTULVH8 DMZJ4VL MN Tyrosinase (TYR) DMZJ4VL MT DTT DMZJ4VL MA Inhibitor DMZJ4VL RN Discovery of 4-functionalized phenyl-O-beta-D-glycosides as a new class of mushroom tyrosinase inhibitors. Bioorg Med Chem Lett. 2009 Nov 1;19(21):6157-60. DMZJ4VL RU https://pubmed.ncbi.nlm.nih.gov/19800229 DM7N3MX DI DM7N3MX DM7N3MX DN 3,4-dihydroxyphenylacetaldehyde DM7N3MX MI DEXI4UQ DM7N3MX MN Aldehyde dehydrogenase 5 (ALDHX) DM7N3MX MT DME DM7N3MX MA Metabolism DM7N3MX RN Neurotoxicity and metabolism of the catecholamine-derived 3,4-dihydroxyphenylacetaldehyde and 3,4-dihydroxyphenylglycolaldehyde: the role of aldehyde dehydrogenase. Pharmacol Rev. 2007 Jun;59(2):125-50. DM7N3MX RU https://www.ncbi.nlm.nih.gov/pubmed/?term=17379813 DM7N3MX DI DM7N3MX DM7N3MX DN 3,4-dihydroxyphenylacetaldehyde DM7N3MX MI DE2ZWSM DM7N3MX MN Aldehyde dehydrogenase 7 (ALDH7) DM7N3MX MT DME DM7N3MX MA Metabolism DM7N3MX RN Neurotoxicity and metabolism of the catecholamine-derived 3,4-dihydroxyphenylacetaldehyde and 3,4-dihydroxyphenylglycolaldehyde: the role of aldehyde dehydrogenase. Pharmacol Rev. 2007 Jun;59(2):125-50. DM7N3MX RU https://www.ncbi.nlm.nih.gov/pubmed/?term=17379813 DM7N3MX DI DM7N3MX DM7N3MX DN 3,4-dihydroxyphenylacetaldehyde DM7N3MX MI DE870HF DM7N3MX MN Aminomuconic semialdehyde dehydrogenase (ALDH12) DM7N3MX MT DME DM7N3MX MA Metabolism DM7N3MX RN Neurotoxicity and metabolism of the catecholamine-derived 3,4-dihydroxyphenylacetaldehyde and 3,4-dihydroxyphenylglycolaldehyde: the role of aldehyde dehydrogenase. Pharmacol Rev. 2007 Jun;59(2):125-50. DM7N3MX RU https://www.ncbi.nlm.nih.gov/pubmed/?term=17379813 DMTQX92 DI DMTQX92 DMTQX92 DN 3,4-dihydroxyxanthone DMTQX92 MI TTVKILB DMTQX92 MN Prostaglandin G/H synthase 2 (COX-2) DMTQX92 MT DTT DMTQX92 MA Inhibitor DMTQX92 RN Selective cyclooxygenase-2 inhibitors from Calophyllum membranaceum. J Nat Prod. 2005 Oct;68(10):1514-8. DMTQX92 RU https://pubmed.ncbi.nlm.nih.gov/16252917 DMVDZCE DI DMVDZCE DMVDZCE DN 3,4-Dimethoxy-4'-amino-trans-stilbene DMVDZCE MI TTSZLWK DMVDZCE MN Aromatase (CYP19A1) DMVDZCE MT DTT DMVDZCE MA Inhibitor DMVDZCE RN Design, synthesis, and biological evaluation of resveratrol analogues as aromatase and quinone reductase 2 inhibitors for chemoprevention of cancer. Bioorg Med Chem. 2010 Jul 15;18(14):5352-66. DMVDZCE RU https://pubmed.ncbi.nlm.nih.gov/20558073 DMMO6QI DI DMMO6QI DMMO6QI DN 3,4-Dimethyl-pyrrolidin-(2Z)-ylideneamine DMMO6QI MI TTZUFI5 DMMO6QI MN Nitric-oxide synthase brain (NOS1) DMMO6QI MT DTT DMMO6QI MA Inhibitor DMMO6QI RN Evaluation of pyrrolidin-2-imines and 1,3-thiazolidin-2-imines as inhibitors of nitric oxide synthase. Bioorg Med Chem Lett. 2004 Sep 6;14(17):4539-44. DMMO6QI RU https://pubmed.ncbi.nlm.nih.gov/15357988 DMMO6QI DI DMMO6QI DMMO6QI DN 3,4-Dimethyl-pyrrolidin-(2Z)-ylideneamine DMMO6QI MI TTCM4B3 DMMO6QI MN Nitric-oxide synthase endothelial (NOS3) DMMO6QI MT DTT DMMO6QI MA Inhibitor DMMO6QI RN Evaluation of pyrrolidin-2-imines and 1,3-thiazolidin-2-imines as inhibitors of nitric oxide synthase. Bioorg Med Chem Lett. 2004 Sep 6;14(17):4539-44. DMMO6QI RU https://pubmed.ncbi.nlm.nih.gov/15357988 DMMO6QI DI DMMO6QI DMMO6QI DN 3,4-Dimethyl-pyrrolidin-(2Z)-ylideneamine DMMO6QI MI TTF10I9 DMMO6QI MN Nitric-oxide synthase inducible (NOS2) DMMO6QI MT DTT DMMO6QI MA Inhibitor DMMO6QI RN Evaluation of pyrrolidin-2-imines and 1,3-thiazolidin-2-imines as inhibitors of nitric oxide synthase. Bioorg Med Chem Lett. 2004 Sep 6;14(17):4539-44. DMMO6QI RU https://pubmed.ncbi.nlm.nih.gov/15357988 DMPK6YT DI DMPK6YT DMPK6YT DN 3,4-diphenyl-1H-pyrrole-2,5-dione DMPK6YT MI TT9VGXW DMPK6YT MN Angiopoietin 1 receptor (TEK) DMPK6YT MT DTT DMPK6YT MA Inhibitor DMPK6YT RN Design, synthesis, and biological evaluation of 3,4-diarylmaleimides as angiogenesis inhibitors. J Med Chem. 2006 Feb 23;49(4):1271-81. DMPK6YT RU https://pubmed.ncbi.nlm.nih.gov/16480264 DMPK6YT DI DMPK6YT DMPK6YT DN 3,4-diphenyl-1H-pyrrole-2,5-dione DMPK6YT MI TTH6V3D DMPK6YT MN Cyclin-dependent kinase 1 (CDK1) DMPK6YT MT DTT DMPK6YT MA Inhibitor DMPK6YT RN Design, synthesis, and biological evaluation of 3,4-diarylmaleimides as angiogenesis inhibitors. J Med Chem. 2006 Feb 23;49(4):1271-81. DMPK6YT RU https://pubmed.ncbi.nlm.nih.gov/16480264 DMPK6YT DI DMPK6YT DMPK6YT DN 3,4-diphenyl-1H-pyrrole-2,5-dione DMPK6YT MI TT7HF4W DMPK6YT MN Cyclin-dependent kinase 2 (CDK2) DMPK6YT MT DTT DMPK6YT MA Inhibitor DMPK6YT RN Design, synthesis, and biological evaluation of 3,4-diarylmaleimides as angiogenesis inhibitors. J Med Chem. 2006 Feb 23;49(4):1271-81. DMPK6YT RU https://pubmed.ncbi.nlm.nih.gov/16480264 DMPK6YT DI DMPK6YT DMPK6YT DN 3,4-diphenyl-1H-pyrrole-2,5-dione DMPK6YT MI TT0PG8F DMPK6YT MN Cyclin-dependent kinase 4 (CDK4) DMPK6YT MT DTT DMPK6YT MA Inhibitor DMPK6YT RN Design, synthesis, and biological evaluation of 3,4-diarylmaleimides as angiogenesis inhibitors. J Med Chem. 2006 Feb 23;49(4):1271-81. DMPK6YT RU https://pubmed.ncbi.nlm.nih.gov/16480264 DMPK6YT DI DMPK6YT DMPK6YT DN 3,4-diphenyl-1H-pyrrole-2,5-dione DMPK6YT MI TTO0FDJ DMPK6YT MN Cyclin-dependent kinase 6 (CDK6) DMPK6YT MT DTT DMPK6YT MA Inhibitor DMPK6YT RN Design, synthesis, and biological evaluation of 3,4-diarylmaleimides as angiogenesis inhibitors. J Med Chem. 2006 Feb 23;49(4):1271-81. DMPK6YT RU https://pubmed.ncbi.nlm.nih.gov/16480264 DMPK6YT DI DMPK6YT DMPK6YT DN 3,4-diphenyl-1H-pyrrole-2,5-dione DMPK6YT MI TTGKNB4 DMPK6YT MN Epidermal growth factor receptor (EGFR) DMPK6YT MT DTT DMPK6YT MA Inhibitor DMPK6YT RN Design, synthesis, and biological evaluation of 3,4-diarylmaleimides as angiogenesis inhibitors. J Med Chem. 2006 Feb 23;49(4):1271-81. DMPK6YT RU https://pubmed.ncbi.nlm.nih.gov/16480264 DMPK6YT DI DMPK6YT DMPK6YT DN 3,4-diphenyl-1H-pyrrole-2,5-dione DMPK6YT MI TTR5TV4 DMPK6YT MN ERBB2 messenger RNA (HER2 mRNA) DMPK6YT MT DTT DMPK6YT MA Inhibitor DMPK6YT RN Design, synthesis, and biological evaluation of 3,4-diarylmaleimides as angiogenesis inhibitors. J Med Chem. 2006 Feb 23;49(4):1271-81. DMPK6YT RU https://pubmed.ncbi.nlm.nih.gov/16480264 DMPK6YT DI DMPK6YT DMPK6YT DN 3,4-diphenyl-1H-pyrrole-2,5-dione DMPK6YT MI TTFCJ7S DMPK6YT MN G1/S-specific cyclin-D1 (CCND1) DMPK6YT MT DTT DMPK6YT MA Inhibitor DMPK6YT RN Design, synthesis, and biological evaluation of 3,4-diarylmaleimides as angiogenesis inhibitors. J Med Chem. 2006 Feb 23;49(4):1271-81. DMPK6YT RU https://pubmed.ncbi.nlm.nih.gov/16480264 DMPK6YT DI DMPK6YT DMPK6YT DN 3,4-diphenyl-1H-pyrrole-2,5-dione DMPK6YT MI TTCEJ4F DMPK6YT MN G1/S-specific cyclin-E1 (CCNE1) DMPK6YT MT DTT DMPK6YT MA Inhibitor DMPK6YT RN Design, synthesis, and biological evaluation of 3,4-diarylmaleimides as angiogenesis inhibitors. J Med Chem. 2006 Feb 23;49(4):1271-81. DMPK6YT RU https://pubmed.ncbi.nlm.nih.gov/16480264 DMPK6YT DI DMPK6YT DMPK6YT DN 3,4-diphenyl-1H-pyrrole-2,5-dione DMPK6YT MI TT9P6OW DMPK6YT MN G2/mitotic-specific cyclin B1 (CCNB1) DMPK6YT MT DTT DMPK6YT MA Inhibitor DMPK6YT RN Design, synthesis, and biological evaluation of 3,4-diarylmaleimides as angiogenesis inhibitors. J Med Chem. 2006 Feb 23;49(4):1271-81. DMPK6YT RU https://pubmed.ncbi.nlm.nih.gov/16480264 DMPK6YT DI DMPK6YT DMPK6YT DN 3,4-diphenyl-1H-pyrrole-2,5-dione DMPK6YT MI TTFJ8Q1 DMPK6YT MN Protein kinase C alpha (PRKCA) DMPK6YT MT DTT DMPK6YT MA Inhibitor DMPK6YT RN Design, synthesis, and biological evaluation of 3,4-diarylmaleimides as angiogenesis inhibitors. J Med Chem. 2006 Feb 23;49(4):1271-81. DMPK6YT RU https://pubmed.ncbi.nlm.nih.gov/16480264 DMPK6YT DI DMPK6YT DMPK6YT DN 3,4-diphenyl-1H-pyrrole-2,5-dione DMPK6YT MI TTBZ7OD DMPK6YT MN Protein kinase C epsilon (PRKCE) DMPK6YT MT DTT DMPK6YT MA Inhibitor DMPK6YT RN Design, synthesis, and biological evaluation of 3,4-diarylmaleimides as angiogenesis inhibitors. J Med Chem. 2006 Feb 23;49(4):1271-81. DMPK6YT RU https://pubmed.ncbi.nlm.nih.gov/16480264 DMPK6YT DI DMPK6YT DMPK6YT DN 3,4-diphenyl-1H-pyrrole-2,5-dione DMPK6YT MI TTRFOXJ DMPK6YT MN Protein kinase C gamma (PRKCG) DMPK6YT MT DTT DMPK6YT MA Inhibitor DMPK6YT RN Design, synthesis, and biological evaluation of 3,4-diarylmaleimides as angiogenesis inhibitors. J Med Chem. 2006 Feb 23;49(4):1271-81. DMPK6YT RU https://pubmed.ncbi.nlm.nih.gov/16480264 DMPK6YT DI DMPK6YT DMPK6YT DN 3,4-diphenyl-1H-pyrrole-2,5-dione DMPK6YT MI TTUTJGQ DMPK6YT MN Vascular endothelial growth factor receptor 2 (KDR) DMPK6YT MT DTT DMPK6YT MA Inhibitor DMPK6YT RN Design, synthesis, and biological evaluation of 3,4-diarylmaleimides as angiogenesis inhibitors. J Med Chem. 2006 Feb 23;49(4):1271-81. DMPK6YT RU https://pubmed.ncbi.nlm.nih.gov/16480264 DM8BJPU DI DM8BJPU DM8BJPU DN 3,4-epoxydehydroleucodin DM8BJPU MI TTSXVID DM8BJPU MN Nuclear factor NF-kappa-B (NFKB) DM8BJPU MT DTT DM8BJPU MA Inhibitor DM8BJPU RN Development of a structural model for NF-kappaB inhibition of sesquiterpene lactones using self-organizing neural networks. J Med Chem. 2006 Apr 6;49(7):2241-52. DM8BJPU RU https://pubmed.ncbi.nlm.nih.gov/16570920 DMLIG3X DI DMLIG3X DMLIG3X DN 3,5 DIBROMOTYROSINE DMLIG3X MI TTAUX24 DMLIG3X MN Erythropoietin Receptor (EPOR) DMLIG3X MT DTT DMLIG3X MA Inhibitor DMLIG3X RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DMLIG3X RU https://pubmed.ncbi.nlm.nih.gov/10592235 DMAU80W DI DMAU80W DMAU80W DN 3,5,6,8-Tetramethyl-N-Methyl Phenanthrolinium DMAU80W MI TTZL0OI DMAU80W MN Methionine aminopeptidase 2 (METAP2) DMAU80W MT DTT DMAU80W MA Inhibitor DMAU80W RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMAU80W RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMV859W DI DMV859W DMV859W DN 3,5-bis(2-methylpyridin-4-yl)-1H-1,2,4-triazole DMV859W MI TT7RJY8 DMV859W MN Xanthine dehydrogenase/oxidase (XDH) DMV859W MT DTT DMV859W MA Inhibitor DMV859W RN Discovery of 3-(2-cyano-4-pyridyl)-5-(4-pyridyl)-1,2,4-triazole, FYX-051 - a xanthine oxidoreductase inhibitor for the treatment of hyperuricemia [... Bioorg Med Chem Lett. 2009 Nov 1;19(21):6225-9. DMV859W RU https://pubmed.ncbi.nlm.nih.gov/19783139 DMFEQ6S DI DMFEQ6S DMFEQ6S DN 3,5-DHPG DMFEQ6S MI TTVBPDM DMFEQ6S MN Metabotropic glutamate receptor 1 (mGluR1) DMFEQ6S MT DTT DMFEQ6S MA Agonist DMFEQ6S RN [3H]R214127: a novel high-affinity radioligand for the mGlu1 receptor reveals a common binding site shared by multiple allosteric antagonists. Mol Pharmacol. 2003 May;63(5):1082-93. DMFEQ6S RU https://pubmed.ncbi.nlm.nih.gov/12695537 DMFEQ6S DI DMFEQ6S DMFEQ6S DN 3,5-DHPG DMFEQ6S MI TTHS256 DMFEQ6S MN Metabotropic glutamate receptor 5 (mGluR5) DMFEQ6S MT DTT DMFEQ6S MA Agonist DMFEQ6S RN Characterization of [(3)H]Quisqualate binding to recombinant rat metabotropic glutamate 1a and 5a receptors and to rat and human brain sections. J Neurochem. 2000 Dec;75(6):2590-601. DMFEQ6S RU https://pubmed.ncbi.nlm.nih.gov/11080213 DM6CBTE DI DM6CBTE DM6CBTE DN 3,5-di(pyridin-4-yl)-1H-1,2,4-triazole DM6CBTE MI TT7RJY8 DM6CBTE MN Xanthine dehydrogenase/oxidase (XDH) DM6CBTE MT DTT DM6CBTE MA Inhibitor DM6CBTE RN Discovery of 3-(2-cyano-4-pyridyl)-5-(4-pyridyl)-1,2,4-triazole, FYX-051 - a xanthine oxidoreductase inhibitor for the treatment of hyperuricemia [... Bioorg Med Chem Lett. 2009 Nov 1;19(21):6225-9. DM6CBTE RU https://pubmed.ncbi.nlm.nih.gov/19783139 DMEXPIJ DI DMEXPIJ DMEXPIJ DN 3,5-Diacetoxy-4'-amino-trans-stilbene DMEXPIJ MI TTSZLWK DMEXPIJ MN Aromatase (CYP19A1) DMEXPIJ MT DTT DMEXPIJ MA Inhibitor DMEXPIJ RN Design, synthesis, and biological evaluation of resveratrol analogues as aromatase and quinone reductase 2 inhibitors for chemoprevention of cancer. Bioorg Med Chem. 2010 Jul 15;18(14):5352-66. DMEXPIJ RU https://pubmed.ncbi.nlm.nih.gov/20558073 DMK9JCA DI DMK9JCA DMK9JCA DN 3,5-Diamino-4'-amino-trans-stilbene DMK9JCA MI TTSZLWK DMK9JCA MN Aromatase (CYP19A1) DMK9JCA MT DTT DMK9JCA MA Inhibitor DMK9JCA RN Design, synthesis, and biological evaluation of resveratrol analogues as aromatase and quinone reductase 2 inhibitors for chemoprevention of cancer. Bioorg Med Chem. 2010 Jul 15;18(14):5352-66. DMK9JCA RU https://pubmed.ncbi.nlm.nih.gov/20558073 DMCEY6O DI DMCEY6O DMCEY6O DN 3,5-dibromo-2-(2,4-dibromophenoxy)phenol DMCEY6O MI TTCFP0V DMCEY6O MN Glutamine amidotransferase (GMPS) DMCEY6O MT DTT DMCEY6O MA Inhibitor DMCEY6O RN Enzyme inhibitors: new and known polybrominated phenols and diphenyl ethers from four Indo-Pacific Dysidea sponges. J Nat Prod. 1995 Sep;58(9):1384-91. DMCEY6O RU https://pubmed.ncbi.nlm.nih.gov/7494145 DMPVI9W DI DMPVI9W DMPVI9W DN 3,5-dichlorobenzaldehyde thiosemicarbazone DMPVI9W MI TTEAID7 DMPVI9W MN Trypanosoma Cruzipain (Trypano CYSP) DMPVI9W MT DTT DMPVI9W MA Inhibitor DMPVI9W RN Synthesis and structure-activity relationship study of potent trypanocidal thio semicarbazone inhibitors of the trypanosomal cysteine protease cruz... J Med Chem. 2002 Jun 20;45(13):2695-707. DMPVI9W RU https://pubmed.ncbi.nlm.nih.gov/12061873 DMQ45WH DI DMQ45WH DMQ45WH DN 3,5-dichlorosalicylic acid DMQ45WH MI TTFBNVI DMQ45WH MN Aldose reductase (AKR1B1) DMQ45WH MT DTT DMQ45WH MA Inhibitor DMQ45WH RN Correlation of binding constants and molecular modelling of inhibitors in the active sites of aldose reductase and aldehyde reductase. Bioorg Med Chem. 2009 Feb 1;17(3):1244-50. DMQ45WH RU https://pubmed.ncbi.nlm.nih.gov/19121944 DMQ45WH DI DMQ45WH DMQ45WH DN 3,5-dichlorosalicylic acid DMQ45WH MI TTJS7O4 DMQ45WH MN Entamoeba Alcohol dehydrogenase 2 (Entamo ADH2) DMQ45WH MT DTT DMQ45WH MA Inhibitor DMQ45WH RN Correlation of binding constants and molecular modelling of inhibitors in the active sites of aldose reductase and aldehyde reductase. Bioorg Med Chem. 2009 Feb 1;17(3):1244-50. DMQ45WH RU https://pubmed.ncbi.nlm.nih.gov/19121944 DMET46F DI DMET46F DMET46F DN 3,5-Difluorobenzenesulfonamide DMET46F MI TTANPDJ DMET46F MN Carbonic anhydrase II (CA-II) DMET46F MT DTT DMET46F MA Inhibitor DMET46F RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMET46F RU https://pubmed.ncbi.nlm.nih.gov/17139284 DM4VT0Q DI DM4VT0Q DM4VT0Q DN 3,5-difluorophenol DM4VT0Q MI TTUNARX DM4VT0Q MN Carbonic anhydrase (CA) DM4VT0Q MT DTT DM4VT0Q MA Inhibitor DM4VT0Q RN Carbonic anhydrase inhibitors: Inhibition of the new membrane-associated isoform XV with phenols. Bioorg Med Chem Lett. 2008 Jun 15;18(12):3593-6. DM4VT0Q RU https://pubmed.ncbi.nlm.nih.gov/18501600 DM04N7I DI DM04N7I DM04N7I DN 3,5-dihydroxybenzoic acid DM04N7I MI TTVK4ZO DM04N7I MN G protein coupled receptor 81 (HCAR1) DM04N7I MT DTT DM04N7I MA Agonist DM04N7I RN 3,5-Dihydroxybenzoic acid, a specific agonist for hydroxycarboxylic acid 1, inhibits lipolysis in adipocytes. J Pharmacol Exp Ther. 2012 Jun;341(3):794-801. DM04N7I RU https://pubmed.ncbi.nlm.nih.gov/22434674 DMQ9TNB DI DMQ9TNB DMQ9TNB DN 3,5-Dihydroxyl-4'-amino-trans-stilbene DMQ9TNB MI TTSZLWK DMQ9TNB MN Aromatase (CYP19A1) DMQ9TNB MT DTT DMQ9TNB MA Inhibitor DMQ9TNB RN Design, synthesis, and biological evaluation of resveratrol analogues as aromatase and quinone reductase 2 inhibitors for chemoprevention of cancer. Bioorg Med Chem. 2010 Jul 15;18(14):5352-66. DMQ9TNB RU https://pubmed.ncbi.nlm.nih.gov/20558073 DMRY2ZC DI DMRY2ZC DMRY2ZC DN 3'',5''-dimethoxy-[1,1':2',1'']-terphenyl-4-ol DMRY2ZC MI TTS7G69 DMRY2ZC MN Fusion protein Bcr-Abl (Bcr-Abl) DMRY2ZC MT DTT DMRY2ZC MA Inhibitor DMRY2ZC RN Identification of a terphenyl derivative that blocks the cell cycle in the G0-G1 phase and induces differentiation in leukemia cells. J Med Chem. 2006 May 18;49(10):3012-8. DMRY2ZC RU https://pubmed.ncbi.nlm.nih.gov/16686543 DMXCZAK DI DMXCZAK DMXCZAK DN 3'',5''-dimethoxy-[1,1':3',1'']-terphenyl-4-ol DMXCZAK MI TTS7G69 DMXCZAK MN Fusion protein Bcr-Abl (Bcr-Abl) DMXCZAK MT DTT DMXCZAK MA Inhibitor DMXCZAK RN Identification of a terphenyl derivative that blocks the cell cycle in the G0-G1 phase and induces differentiation in leukemia cells. J Med Chem. 2006 May 18;49(10):3012-8. DMXCZAK RU https://pubmed.ncbi.nlm.nih.gov/16686543 DMC3917 DI DMC3917 DMC3917 DN 3,5-Dimethoxy-4'-amino-trans-stilbene DMC3917 MI TTSZLWK DMC3917 MN Aromatase (CYP19A1) DMC3917 MT DTT DMC3917 MA Inhibitor DMC3917 RN Design, synthesis, and biological evaluation of resveratrol analogues as aromatase and quinone reductase 2 inhibitors for chemoprevention of cancer. Bioorg Med Chem. 2010 Jul 15;18(14):5352-66. DMC3917 RU https://pubmed.ncbi.nlm.nih.gov/20558073 DMC3917 DI DMC3917 DMC3917 DN 3,5-Dimethoxy-4'-amino-trans-stilbene DMC3917 MI TTJLP0R DMC3917 MN Quinone reductase 2 (NQO2) DMC3917 MT DTT DMC3917 MA Inhibitor DMC3917 RN Design, synthesis, and biological evaluation of resveratrol analogues as aromatase and quinone reductase 2 inhibitors for chemoprevention of cancer. Bioorg Med Chem. 2010 Jul 15;18(14):5352-66. DMC3917 RU https://pubmed.ncbi.nlm.nih.gov/20558073 DM3E98I DI DM3E98I DM3E98I DN 3,5-dimethyl PPP DM3E98I MI TTVBPDM DM3E98I MN Metabotropic glutamate receptor 1 (mGluR1) DM3E98I MT DTT DM3E98I MA Modulator (allosteric modulator) DM3E98I RN Synthesis and pharmacological characterisation of 2,4-dicarboxy-pyrroles as selective non-competitive mGluR1 antagonists. Bioorg Med Chem. 2003 Jan 17;11(2):171-83. DM3E98I RU https://pubmed.ncbi.nlm.nih.gov/12470711 DMAQ6OM DI DMAQ6OM DMAQ6OM DN 3,5-dimethyl-2-(phenylsulfonamido)benzoic acid DMAQ6OM MI TTZL0OI DMAQ6OM MN Methionine aminopeptidase 2 (METAP2) DMAQ6OM MT DTT DMAQ6OM MA Inhibitor DMAQ6OM RN Development of sulfonamide compounds as potent methionine aminopeptidase type II inhibitors with antiproliferative properties. Bioorg Med Chem Lett. 2006 Jul 1;16(13):3574-7. DMAQ6OM RU https://pubmed.ncbi.nlm.nih.gov/16632353 DMBGSHD DI DMBGSHD DMBGSHD DN 3,5-Dinitrocatechol DMBGSHD MI TTKWFB8 DMBGSHD MN Catechol-O-methyl-transferase (COMT) DMBGSHD MT DTT DMBGSHD MA Inhibitor DMBGSHD RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMBGSHD RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMWOB7Q DI DMWOB7Q DMWOB7Q DN 3,5-Di-tert-butyl-[1,2]benzoquinone DMWOB7Q MI TTMF541 DMWOB7Q MN Liver carboxylesterase (CES1) DMWOB7Q MT DTT DMWOB7Q MA Inhibitor DMWOB7Q RN Identification and characterization of novel benzil (diphenylethane-1,2-dione) analogues as inhibitors of mammalian carboxylesterases. J Med Chem. 2005 Apr 21;48(8):2906-15. DMWOB7Q RU https://pubmed.ncbi.nlm.nih.gov/15828829 DMM632N DI DMM632N DMM632N DN 3,6,8-Tribromo-dibenzo[1,4]dioxin-1-ol DMM632N MI TTN9T81 DMM632N MN Arachidonate 15-lipoxygenase (15-LOX) DMM632N MT DTT DMM632N MA Inhibitor DMM632N RN Probing the activity differences of simple and complex brominated aryl compounds against 15-soybean, 15-human, and 12-human lipoxygenase. J Med Chem. 2004 Jul 29;47(16):4060-5. DMM632N RU https://pubmed.ncbi.nlm.nih.gov/15267244 DMY26JI DI DMY26JI DMY26JI DN 3,6,9,12,15,18-HEXAOXAICOSANE DMY26JI MI TTJNTSI DMY26JI MN Rotamase Pin1 (PIN1) DMY26JI MT DTT DMY26JI MA Inhibitor DMY26JI RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DMY26JI RU https://pubmed.ncbi.nlm.nih.gov/10592235 DMY8IOP DI DMY8IOP DMY8IOP DN 3,6,9,12,15-Pentaoxaheptadecane DMY8IOP MI TT1RS9F DMY8IOP MN Acetylcholinesterase (AChE) DMY8IOP MT DTT DMY8IOP MA Inhibitor DMY8IOP RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DMY8IOP RU https://pubmed.ncbi.nlm.nih.gov/10592235 DMY8IOP DI DMY8IOP DMY8IOP DN 3,6,9,12,15-Pentaoxaheptadecane DMY8IOP MI TTWQM3J DMY8IOP MN Kynureninase (KYNU) DMY8IOP MT DTT DMY8IOP MA Inhibitor DMY8IOP RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DMY8IOP RU https://pubmed.ncbi.nlm.nih.gov/10592235 DMMVL5P DI DMMVL5P DMMVL5P DN 3,6,9,12,15-PENTAOXATRICOSAN-1-OL DMMVL5P MI TT3PQ2Y DMMVL5P MN Plasmodium Dihydroorotate dehydrogenase (Malaria DHOdehase) DMMVL5P MT DTT DMMVL5P MA Inhibitor DMMVL5P RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DMMVL5P RU https://pubmed.ncbi.nlm.nih.gov/10592235 DMWTP7Y DI DMWTP7Y DMWTP7Y DN 3,6-bis(Dmt-Tic-NH-butyl)-2(1H)-pyrazinone DMWTP7Y MI TT27RFC DMWTP7Y MN Opioid receptor delta (OPRD1) DMWTP7Y MT DTT DMWTP7Y MA Inhibitor DMWTP7Y RN Potent Dmt-Tic pharmacophoric delta- and mu-opioid receptor antagonists. J Med Chem. 2005 Dec 15;48(25):8035-44. DMWTP7Y RU https://pubmed.ncbi.nlm.nih.gov/16335927 DMWTP7Y DI DMWTP7Y DMWTP7Y DN 3,6-bis(Dmt-Tic-NH-butyl)-2(1H)-pyrazinone DMWTP7Y MI TTKWM86 DMWTP7Y MN Opioid receptor mu (MOP) DMWTP7Y MT DTT DMWTP7Y MA Inhibitor DMWTP7Y RN Potent Dmt-Tic pharmacophoric delta- and mu-opioid receptor antagonists. J Med Chem. 2005 Dec 15;48(25):8035-44. DMWTP7Y RU https://pubmed.ncbi.nlm.nih.gov/16335927 DM2Y4A6 DI DM2Y4A6 DM2Y4A6 DN 3,6-bis(Dmt-Tic-NH-ethyl)-2(1H)-pyrazinone DM2Y4A6 MI TT27RFC DM2Y4A6 MN Opioid receptor delta (OPRD1) DM2Y4A6 MT DTT DM2Y4A6 MA Inhibitor DM2Y4A6 RN Potent Dmt-Tic pharmacophoric delta- and mu-opioid receptor antagonists. J Med Chem. 2005 Dec 15;48(25):8035-44. DM2Y4A6 RU https://pubmed.ncbi.nlm.nih.gov/16335927 DM2Y4A6 DI DM2Y4A6 DM2Y4A6 DN 3,6-bis(Dmt-Tic-NH-ethyl)-2(1H)-pyrazinone DM2Y4A6 MI TTKWM86 DM2Y4A6 MN Opioid receptor mu (MOP) DM2Y4A6 MT DTT DM2Y4A6 MA Inhibitor DM2Y4A6 RN Potent Dmt-Tic pharmacophoric delta- and mu-opioid receptor antagonists. J Med Chem. 2005 Dec 15;48(25):8035-44. DM2Y4A6 RU https://pubmed.ncbi.nlm.nih.gov/16335927 DMJR983 DI DMJR983 DMJR983 DN 3,6-bis(Dmt-Tic-NH-methyl)-2(1H)-pyrazinone DMJR983 MI TT27RFC DMJR983 MN Opioid receptor delta (OPRD1) DMJR983 MT DTT DMJR983 MA Inhibitor DMJR983 RN Potent Dmt-Tic pharmacophoric delta- and mu-opioid receptor antagonists. J Med Chem. 2005 Dec 15;48(25):8035-44. DMJR983 RU https://pubmed.ncbi.nlm.nih.gov/16335927 DMJR983 DI DMJR983 DMJR983 DN 3,6-bis(Dmt-Tic-NH-methyl)-2(1H)-pyrazinone DMJR983 MI TTKWM86 DMJR983 MN Opioid receptor mu (MOP) DMJR983 MT DTT DMJR983 MA Inhibitor DMJR983 RN Potent Dmt-Tic pharmacophoric delta- and mu-opioid receptor antagonists. J Med Chem. 2005 Dec 15;48(25):8035-44. DMJR983 RU https://pubmed.ncbi.nlm.nih.gov/16335927 DMEQBS3 DI DMEQBS3 DMEQBS3 DN 3,6-bis(Dmt-Tic-NH-propyl)-2(1H)-pyrazinone DMEQBS3 MI TT27RFC DMEQBS3 MN Opioid receptor delta (OPRD1) DMEQBS3 MT DTT DMEQBS3 MA Inhibitor DMEQBS3 RN Potent Dmt-Tic pharmacophoric delta- and mu-opioid receptor antagonists. J Med Chem. 2005 Dec 15;48(25):8035-44. DMEQBS3 RU https://pubmed.ncbi.nlm.nih.gov/16335927 DMEQBS3 DI DMEQBS3 DMEQBS3 DN 3,6-bis(Dmt-Tic-NH-propyl)-2(1H)-pyrazinone DMEQBS3 MI TTKWM86 DMEQBS3 MN Opioid receptor mu (MOP) DMEQBS3 MT DTT DMEQBS3 MA Inhibitor DMEQBS3 RN Potent Dmt-Tic pharmacophoric delta- and mu-opioid receptor antagonists. J Med Chem. 2005 Dec 15;48(25):8035-44. DMEQBS3 RU https://pubmed.ncbi.nlm.nih.gov/16335927 DMUH4OV DI DMUH4OV DMUH4OV DN 3,6-Dihydroxy-2-(4-hydroxy-phenyl)-inden-1-one DMUH4OV MI TTOM3J0 DMUH4OV MN Estrogen receptor beta (ESR2) DMUH4OV MT DTT DMUH4OV MA Inhibitor DMUH4OV RN Estrogen receptor ligands: design and synthesis of new 2-arylindene-1-ones. Bioorg Med Chem Lett. 2005 Jun 15;15(12):3137-42. DMUH4OV RU https://pubmed.ncbi.nlm.nih.gov/15876535 DM7AORH DI DM7AORH DM7AORH DN 3,6-Dihydroxy-Xanthene-9-Propionic Acid DM7AORH MI TTEP6RV DM7AORH MN Glutathione reductase (GR) DM7AORH MT DTT DM7AORH MA Inhibitor DM7AORH RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DM7AORH RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMEOBNJ DI DMEOBNJ DMEOBNJ DN 3,6-Diphenyl-1-oxa-7-aza-spiro[4.5]decane DMEOBNJ MI TTZPO1L DMEOBNJ MN Substance-P receptor (TACR1) DMEOBNJ MT DTT DMEOBNJ MA Inhibitor DMEOBNJ RN Spirocyclic NK(1) antagonists II: [4.5]-spiroethers. Bioorg Med Chem Lett. 2002 Oct 7;12(19):2719-22. DMEOBNJ RU https://pubmed.ncbi.nlm.nih.gov/12217362 DMNV0EZ DI DMNV0EZ DMNV0EZ DN 3,6-Di-pyridin-4-yl-pyrazolo[1,5-a]pyrimidine DMNV0EZ MI TTUTJGQ DMNV0EZ MN Vascular endothelial growth factor receptor 2 (KDR) DMNV0EZ MT DTT DMNV0EZ MA Inhibitor DMNV0EZ RN Optimization of a pyrazolo[1,5-a]pyrimidine class of KDR kinase inhibitors: improvements in physical properties enhance cellular activity and pharm... Bioorg Med Chem Lett. 2002 Dec 16;12(24):3537-41. DMNV0EZ RU https://pubmed.ncbi.nlm.nih.gov/12443771 DMNV0EZ DI DMNV0EZ DMNV0EZ DN 3,6-Di-pyridin-4-yl-pyrazolo[1,5-a]pyrimidine DMNV0EZ MI TTDCBX5 DMNV0EZ MN Vascular endothelial growth factor receptor 3 (FLT-4) DMNV0EZ MT DTT DMNV0EZ MA Inhibitor DMNV0EZ RN Synthesis and initial SAR studies of 3,6-disubstituted pyrazolo[1,5-a]pyrimidines: a new class of KDR kinase inhibitors. Bioorg Med Chem Lett. 2002 Oct 7;12(19):2767-70. DMNV0EZ RU https://pubmed.ncbi.nlm.nih.gov/12217372 DMNV0EZ DI DMNV0EZ DMNV0EZ DN 3,6-Di-pyridin-4-yl-pyrazolo[1,5-a]pyrimidine DMNV0EZ MI TT1VAUK DMNV0EZ MN VEGFR1 messenger RNA (VEGFR1 mRNA) DMNV0EZ MT DTT DMNV0EZ MA Inhibitor DMNV0EZ RN Synthesis and initial SAR studies of 3,6-disubstituted pyrazolo[1,5-a]pyrimidines: a new class of KDR kinase inhibitors. Bioorg Med Chem Lett. 2002 Oct 7;12(19):2767-70. DMNV0EZ RU https://pubmed.ncbi.nlm.nih.gov/12217372 DMES906 DI DMES906 DMES906 DN 3,7,3',4'-TETRAHYDROXYFLAVONE DMES906 MI TTO0FDJ DMES906 MN Cyclin-dependent kinase 6 (CDK6) DMES906 MT DTT DMES906 MA Inhibitor DMES906 RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DMES906 RU https://pubmed.ncbi.nlm.nih.gov/10592235 DMES906 DI DMES906 DMES906 DN 3,7,3',4'-TETRAHYDROXYFLAVONE DMES906 MI TT7AOUD DMES906 MN Fatty acid synthase (FASN) DMES906 MT DTT DMES906 MA Inhibitor DMES906 RN Inhibition of Plasmodium falciparum fatty acid biosynthesis: evaluation of FabG, FabZ, and FabI as drug targets for flavonoids. J Med Chem. 2006 Jun 1;49(11):3345-53. DMES906 RU https://pubmed.ncbi.nlm.nih.gov/16722653 DMES906 DI DMES906 DMES906 DN 3,7,3',4'-TETRAHYDROXYFLAVONE DMES906 MI TTHPFTS DMES906 MN Plasmodium Beta-hydroxyacyl-ACP dehydratase (Malaria FabZ) DMES906 MT DTT DMES906 MA Inhibitor DMES906 RN Inhibition of Plasmodium falciparum fatty acid biosynthesis: evaluation of FabG, FabZ, and FabI as drug targets for flavonoids. J Med Chem. 2006 Jun 1;49(11):3345-53. DMES906 RU https://pubmed.ncbi.nlm.nih.gov/16722653 DMES906 DI DMES906 DMES906 DN 3,7,3',4'-TETRAHYDROXYFLAVONE DMES906 MI TTNX2CS DMES906 MN Plasmodium Enoyl-ACP reductase (Malaria fabI) DMES906 MT DTT DMES906 MA Inhibitor DMES906 RN Inhibition of Plasmodium falciparum fatty acid biosynthesis: evaluation of FabG, FabZ, and FabI as drug targets for flavonoids. J Med Chem. 2006 Jun 1;49(11):3345-53. DMES906 RU https://pubmed.ncbi.nlm.nih.gov/16722653 DMES906 DI DMES906 DMES906 DN 3,7,3',4'-TETRAHYDROXYFLAVONE DMES906 MI TTBE4IR DMES906 MN Plasmodium Oxoacyl-[acyl-carrier protein] reductase (Malaria fabG) DMES906 MT DTT DMES906 MA Inhibitor DMES906 RN Inhibition of Plasmodium falciparum fatty acid biosynthesis: evaluation of FabG, FabZ, and FabI as drug targets for flavonoids. J Med Chem. 2006 Jun 1;49(11):3345-53. DMES906 RU https://pubmed.ncbi.nlm.nih.gov/16722653 DMQADXL DI DMQADXL DMQADXL DN 3,7-Bis(2-hydroxyethyl)icaritin DMQADXL MI TTJ0IQB DMQADXL MN Phosphodiesterase 5A (PDE5A) DMQADXL MT DTT DMQADXL MA Inhibitor DMQADXL RN Potent inhibition of human phosphodiesterase-5 by icariin derivatives. J Nat Prod. 2008 Sep;71(9):1513-7. DMQADXL RU https://pubmed.ncbi.nlm.nih.gov/18778098 DMBIRC6 DI DMBIRC6 DMBIRC6 DN 3,7-BIS(DIMETHYLAMINO)PHENOTHIAZIN-5-IUM DMBIRC6 MI TT1RS9F DMBIRC6 MN Acetylcholinesterase (AChE) DMBIRC6 MT DTT DMBIRC6 MA Inhibitor DMBIRC6 RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DMBIRC6 RU https://pubmed.ncbi.nlm.nih.gov/10592235 DMH04P7 DI DMH04P7 DMH04P7 DN 3,7-dihydroxy-flavone DMH04P7 MI TTNX2CS DMH04P7 MN Plasmodium Enoyl-ACP reductase (Malaria fabI) DMH04P7 MT DTT DMH04P7 MA Inhibitor DMH04P7 RN Inhibition of Plasmodium falciparum fatty acid biosynthesis: evaluation of FabG, FabZ, and FabI as drug targets for flavonoids. J Med Chem. 2006 Jun 1;49(11):3345-53. DMH04P7 RU https://pubmed.ncbi.nlm.nih.gov/16722653 DMJ0654 DI DMJ0654 DMJ0654 DN 3,7-DIHYDROXYNAPHTHALENE-2-CARBOXYLIC ACID DMJ0654 MI TTAZHU0 DMJ0654 MN L-lactate dehydrogenase (LDH) DMJ0654 MT DTT DMJ0654 MA Inhibitor DMJ0654 RN DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Nucleic Acids Res. 2011 Jan;39(Database issue):D1035-41. DMJ0654 RU https://pubmed.ncbi.nlm.nih.gov/21059682 DM23CEI DI DM23CEI DM23CEI DN 3,8-dibromoboldine DM23CEI MI TTZFYLI DM23CEI MN Dopamine D1 receptor (D1R) DM23CEI MT DTT DM23CEI MA Inhibitor DM23CEI RN Halogenated boldine derivatives with enhanced monoamine receptor selectivity. J Nat Prod. 2000 Apr;63(4):480-4. DM23CEI RU https://pubmed.ncbi.nlm.nih.gov/10785418 DM23CEI DI DM23CEI DM23CEI DN 3,8-dibromoboldine DM23CEI MI TTEX248 DM23CEI MN Dopamine D2 receptor (D2R) DM23CEI MT DTT DM23CEI MA Inhibitor DM23CEI RN Halogenated boldine derivatives with enhanced monoamine receptor selectivity. J Nat Prod. 2000 Apr;63(4):480-4. DM23CEI RU https://pubmed.ncbi.nlm.nih.gov/10785418 DM23CEI DI DM23CEI DM23CEI DN 3,8-dibromoboldine DM23CEI MI TTLA931 DM23CEI MN Neuronal acetylcholine receptor alpha-7 (CHRNA7) DM23CEI MT DTT DM23CEI MA Inhibitor DM23CEI RN Aporphine metho salts as neuronal nicotinic acetylcholine receptor blockers. Bioorg Med Chem. 2007 May 15;15(10):3368-72. DM23CEI RU https://pubmed.ncbi.nlm.nih.gov/17391965 DMIFJRS DI DMIFJRS DMIFJRS DN 3,8-dihydroxy-4-methyl-6H-benzo[c]chromen-6-one DMIFJRS MI TTZAYWL DMIFJRS MN Estrogen receptor (ESR) DMIFJRS MT DTT DMIFJRS MA Inhibitor DMIFJRS RN 6H-Benzo[c]chromen-6-one derivatives as selective ERbeta agonists. Bioorg Med Chem Lett. 2006 Mar 15;16(6):1468-72. DMIFJRS RU https://pubmed.ncbi.nlm.nih.gov/16412638 DMIFJRS DI DMIFJRS DMIFJRS DN 3,8-dihydroxy-4-methyl-6H-benzo[c]chromen-6-one DMIFJRS MI TTOM3J0 DMIFJRS MN Estrogen receptor beta (ESR2) DMIFJRS MT DTT DMIFJRS MA Inhibitor DMIFJRS RN 6H-Benzo[c]chromen-6-one derivatives as selective ERbeta agonists. Bioorg Med Chem Lett. 2006 Mar 15;16(6):1468-72. DMIFJRS RU https://pubmed.ncbi.nlm.nih.gov/16412638 DMW0B4H DI DMW0B4H DMW0B4H DN 3,8-dihydroxy-7-methyl-6H-benzo[c]chromen-6-one DMW0B4H MI TTZAYWL DMW0B4H MN Estrogen receptor (ESR) DMW0B4H MT DTT DMW0B4H MA Inhibitor DMW0B4H RN 6H-Benzo[c]chromen-6-one derivatives as selective ERbeta agonists. Bioorg Med Chem Lett. 2006 Mar 15;16(6):1468-72. DMW0B4H RU https://pubmed.ncbi.nlm.nih.gov/16412638 DMW0B4H DI DMW0B4H DMW0B4H DN 3,8-dihydroxy-7-methyl-6H-benzo[c]chromen-6-one DMW0B4H MI TTOM3J0 DMW0B4H MN Estrogen receptor beta (ESR2) DMW0B4H MT DTT DMW0B4H MA Inhibitor DMW0B4H RN 6H-Benzo[c]chromen-6-one derivatives as selective ERbeta agonists. Bioorg Med Chem Lett. 2006 Mar 15;16(6):1468-72. DMW0B4H RU https://pubmed.ncbi.nlm.nih.gov/16412638 DMXZ8RJ DI DMXZ8RJ DMXZ8RJ DN 3,9-dihydroxy-2,10-diprenylpterocap-6a-ene DMXZ8RJ MI TT9V5JH DMXZ8RJ MN Phospholipase A2 (PLA2G1B) DMXZ8RJ MT DTT DMXZ8RJ MA Inhibitor DMXZ8RJ RN Phospholipase A2 Inhibitors from an Erythrina Species from Samoa J. Nat. Prod. 60(6):537-539 (1997). DMXZ8RJ RU http://pubs.acs.org/doi/abs/10.1021/np960533e DMK53AT DI DMK53AT DMK53AT DN 3,9-Dihydroxy-4-prenyl-[6aR,11aR]pterocarpan DMK53AT MI TTELIN2 DMK53AT MN PTPN1 messenger RNA (PTPN1 mRNA) DMK53AT MT DTT DMK53AT MA Inhibitor DMK53AT RN Cytotoxic and PTP1B inhibitory activities from Erythrina abyssinica. Bioorg Med Chem Lett. 2009 Dec 1;19(23):6745-9. DMK53AT RU https://pubmed.ncbi.nlm.nih.gov/19836230 DMLSET4 DI DMLSET4 DMLSET4 DN 3-[(1-carboxy-4-mercaptobutyl)thio]benzoic acid DMLSET4 MI TT9G4N0 DMLSET4 MN Glutamate carboxypeptidase II (GCPII) DMLSET4 MT DTT DMLSET4 MA Inhibitor DMLSET4 RN Structural optimization of thiol-based inhibitors of glutamate carboxypeptidase II by modification of the P1' side chain. J Med Chem. 2006 May 18;49(10):2876-85. DMLSET4 RU https://pubmed.ncbi.nlm.nih.gov/16686531 DM2KXFS DI DM2KXFS DM2KXFS DN 3-[(1s)-1-(Dimethylamino)Ethyl]Phenol DM2KXFS MI TT1RS9F DM2KXFS MN Acetylcholinesterase (AChE) DM2KXFS MT DTT DM2KXFS MA Inhibitor DM2KXFS RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DM2KXFS RU https://pubmed.ncbi.nlm.nih.gov/10592235 DMBAHRJ DI DMBAHRJ DMBAHRJ DN 3-[(2,5-dimethyl-4-thiazolyl)ethynyl]pyridine DMBAHRJ MI TTHS256 DMBAHRJ MN Metabotropic glutamate receptor 5 (mGluR5) DMBAHRJ MT DTT DMBAHRJ MA Inhibitor DMBAHRJ RN Synthesis and structure-activity relationships of 3-[(2-methyl-1,3-thiazol-4-yl)ethynyl]pyridine analogues as potent, noncompetitive metabotropic g... J Med Chem. 2006 Feb 9;49(3):1080-100. DMBAHRJ RU https://pubmed.ncbi.nlm.nih.gov/16451073 DMZ78WB DI DMZ78WB DMZ78WB DN 3-[(2-methyl-4-thiazolyl)ethynyl]-5-vinylpyridine DMZ78WB MI TTHS256 DMZ78WB MN Metabotropic glutamate receptor 5 (mGluR5) DMZ78WB MT DTT DMZ78WB MA Inhibitor DMZ78WB RN Synthesis and structure-activity relationships of 3-[(2-methyl-1,3-thiazol-4-yl)ethynyl]pyridine analogues as potent, noncompetitive metabotropic g... J Med Chem. 2006 Feb 9;49(3):1080-100. DMZ78WB RU https://pubmed.ncbi.nlm.nih.gov/16451073 DMMLDOZ DI DMMLDOZ DMMLDOZ DN 3-[(2-methyl-4-thiazolyl)ethynyl]benzamide DMMLDOZ MI TTHS256 DMMLDOZ MN Metabotropic glutamate receptor 5 (mGluR5) DMMLDOZ MT DTT DMMLDOZ MA Inhibitor DMMLDOZ RN Synthesis and structure-activity relationships of 3-[(2-methyl-1,3-thiazol-4-yl)ethynyl]pyridine analogues as potent, noncompetitive metabotropic g... J Med Chem. 2006 Feb 9;49(3):1080-100. DMMLDOZ RU https://pubmed.ncbi.nlm.nih.gov/16451073 DMQUDR1 DI DMQUDR1 DMQUDR1 DN 3-[(2-methyl-4-thiazolyl)ethynyl]benzonitrile DMQUDR1 MI TTHS256 DMQUDR1 MN Metabotropic glutamate receptor 5 (mGluR5) DMQUDR1 MT DTT DMQUDR1 MA Inhibitor DMQUDR1 RN Discovery of novel modulators of metabotropic glutamate receptor subtype-5. Bioorg Med Chem. 2004 Jan 2;12(1):17-21. DMQUDR1 RU https://pubmed.ncbi.nlm.nih.gov/14697765 DMF0QM2 DI DMF0QM2 DMF0QM2 DN 3-[(2-methyl-4-thiazolyl)ethynyl]phenol DMF0QM2 MI TTHS256 DMF0QM2 MN Metabotropic glutamate receptor 5 (mGluR5) DMF0QM2 MT DTT DMF0QM2 MA Inhibitor DMF0QM2 RN Synthesis and structure-activity relationships of 3-[(2-methyl-1,3-thiazol-4-yl)ethynyl]pyridine analogues as potent, noncompetitive metabotropic g... J Med Chem. 2006 Feb 9;49(3):1080-100. DMF0QM2 RU https://pubmed.ncbi.nlm.nih.gov/16451073 DMHISM2 DI DMHISM2 DMHISM2 DN 3-[(4'-Hydroxybiphenyl-4-yl)methyl]pyridine DMHISM2 MI TTRA5BZ DMHISM2 MN Steroid 17-alpha-monooxygenase (S17AH) DMHISM2 MT DTT DMHISM2 MA Inhibitor DMHISM2 RN Replacement of imidazolyl by pyridyl in biphenylmethylenes results in selective CYP17 and dual CYP17/CYP11B1 inhibitors for the treatment of prosta... J Med Chem. 2010 Aug 12;53(15):5749-58. DMHISM2 RU https://pubmed.ncbi.nlm.nih.gov/20684610 DM9OI2R DI DM9OI2R DM9OI2R DN 3-[(5-ethyl-2-methyl-4-thiazolyl)ethynyl]pyridine DM9OI2R MI TTHS256 DM9OI2R MN Metabotropic glutamate receptor 5 (mGluR5) DM9OI2R MT DTT DM9OI2R MA Inhibitor DM9OI2R RN Synthesis and structure-activity relationships of 3-[(2-methyl-1,3-thiazol-4-yl)ethynyl]pyridine analogues as potent, noncompetitive metabotropic g... J Med Chem. 2006 Feb 9;49(3):1080-100. DM9OI2R RU https://pubmed.ncbi.nlm.nih.gov/16451073 DMH5329 DI DMH5329 DMH5329 DN 3-[(6-Methylpyridin-2-yl)ethynyl]benzonitrile DMH5329 MI TTHS256 DMH5329 MN Metabotropic glutamate receptor 5 (mGluR5) DMH5329 MT DTT DMH5329 MA Inhibitor DMH5329 RN Structure-activity relationships comparing N-(6-methylpyridin-yl)-substituted aryl amides to 2-methyl-6-(substituted-arylethynyl)pyridines or 2-met... J Med Chem. 2009 Jun 11;52(11):3563-75. DMH5329 RU https://pubmed.ncbi.nlm.nih.gov/19445453 DMNPKZ6 DI DMNPKZ6 DMNPKZ6 DN 3-[(Z)-2-phenylvinyl]pyridine DMNPKZ6 MI TTIQUX7 DMNPKZ6 MN Steroid 11-beta-hydroxylase (CYP11B1) DMNPKZ6 MT DTT DMNPKZ6 MA Inhibitor DMNPKZ6 RN Synthesis and evaluation of heteroaryl-substituted dihydronaphthalenes and indenes: potent and selective inhibitors of aldosterone synthase (CYP11B... J Med Chem. 2006 Apr 6;49(7):2222-31. DMNPKZ6 RU https://pubmed.ncbi.nlm.nih.gov/16570918 DM7URMW DI DM7URMW DM7URMW DN 3-[1-(4-Bromobenzyl)-1H-imidazol-5-yl]-1-propanol DM7URMW MI TTIQUX7 DM7URMW MN Steroid 11-beta-hydroxylase (CYP11B1) DM7URMW MT DTT DM7URMW MA Inhibitor DM7URMW RN Synthesis, biological evaluation, and molecular modeling of 1-benzyl-1H-imidazoles as selective inhibitors of aldosterone synthase (CYP11B2). J Med Chem. 2010 Feb 25;53(4):1712-25. DM7URMW RU https://pubmed.ncbi.nlm.nih.gov/20121113 DM63IKF DI DM63IKF DM63IKF DN 3-[1-(4-Cyanobenzyl)-1H-imidazol-5-yl]-1-propanol DM63IKF MI TTIQUX7 DM63IKF MN Steroid 11-beta-hydroxylase (CYP11B1) DM63IKF MT DTT DM63IKF MA Inhibitor DM63IKF RN Synthesis, biological evaluation, and molecular modeling of 1-benzyl-1H-imidazoles as selective inhibitors of aldosterone synthase (CYP11B2). J Med Chem. 2010 Feb 25;53(4):1712-25. DM63IKF RU https://pubmed.ncbi.nlm.nih.gov/20121113 DMIHWAJ DI DMIHWAJ DMIHWAJ DN 3-[1'-{4'-(Benzyloxy)-phenyl}]-quinuclidine-2-ene DMIHWAJ MI TTFQEO5 DMIHWAJ MN Squalene synthetase (FDFT1) DMIHWAJ MT DTT DMIHWAJ MA Inhibitor DMIHWAJ RN Quinuclidine derivatives as potential antiparasitics. Antimicrob Agents Chemother. 2007 Nov;51(11):4049-61. DMIHWAJ RU https://pubmed.ncbi.nlm.nih.gov/17709461 DMBHUP3 DI DMBHUP3 DMBHUP3 DN 3-[10-(benzylmethylamino)decyloxy]xanthen-9-one DMBHUP3 MI TTEB0GD DMBHUP3 MN Cholinesterase (BCHE) DMBHUP3 MT DTT DMBHUP3 MA Inhibitor DMBHUP3 RN Cholinesterase inhibitors: SAR and enzyme inhibitory activity of 3-[omega-(benzylmethylamino)alkoxy]xanthen-9-ones. Bioorg Med Chem. 2007 Jan 1;15(1):575-85. DMBHUP3 RU https://pubmed.ncbi.nlm.nih.gov/17008100 DM287UO DI DM287UO DM287UO DN 3-[11-(benzylmethylamino)undecyloxy]xanthen-9-one DM287UO MI TTEB0GD DM287UO MN Cholinesterase (BCHE) DM287UO MT DTT DM287UO MA Inhibitor DM287UO RN Cholinesterase inhibitors: SAR and enzyme inhibitory activity of 3-[omega-(benzylmethylamino)alkoxy]xanthen-9-ones. Bioorg Med Chem. 2007 Jan 1;15(1):575-85. DM287UO RU https://pubmed.ncbi.nlm.nih.gov/17008100 DM9KVHQ DI DM9KVHQ DM9KVHQ DN 3-[12-(benzylmethylamino)dodecyloxy]xanthen-9-one DM9KVHQ MI TTEB0GD DM9KVHQ MN Cholinesterase (BCHE) DM9KVHQ MT DTT DM9KVHQ MA Inhibitor DM9KVHQ RN Cholinesterase inhibitors: SAR and enzyme inhibitory activity of 3-[omega-(benzylmethylamino)alkoxy]xanthen-9-ones. Bioorg Med Chem. 2007 Jan 1;15(1):575-85. DM9KVHQ RU https://pubmed.ncbi.nlm.nih.gov/17008100 DMPTI1Z DI DMPTI1Z DMPTI1Z DN 3-[1-ethyl-2-(3-hydroxyphenyl)butyl]phenol DMPTI1Z MI TTZAYWL DMPTI1Z MN Estrogen receptor (ESR) DMPTI1Z MT DTT DMPTI1Z MA Inhibitor DMPTI1Z RN Influence of alkyl chain ramification on estradiol receptor binding affinity and intrinsic activity of 1,2-dialkylated 1,2-bis(4- or 3-hydroxypheny... J Med Chem. 1986 Sep;29(9):1668-74. DMPTI1Z RU https://pubmed.ncbi.nlm.nih.gov/3018243 DMPTI1Z DI DMPTI1Z DMPTI1Z DN 3-[1-ethyl-2-(3-hydroxyphenyl)butyl]phenol DMPTI1Z MI TTOM3J0 DMPTI1Z MN Estrogen receptor beta (ESR2) DMPTI1Z MT DTT DMPTI1Z MA Inhibitor DMPTI1Z RN Influence of alkyl chain ramification on estradiol receptor binding affinity and intrinsic activity of 1,2-dialkylated 1,2-bis(4- or 3-hydroxypheny... J Med Chem. 1986 Sep;29(9):1668-74. DMPTI1Z RU https://pubmed.ncbi.nlm.nih.gov/3018243 DME1UNY DI DME1UNY DME1UNY DN 3-[2-(1-Benzyl-piperidin-4-yl)-ethyl]-1H-indazole DME1UNY MI TT1RS9F DME1UNY MN Acetylcholinesterase (AChE) DME1UNY MT DTT DME1UNY MA Inhibitor DME1UNY RN A docking score function for estimating ligand-protein interactions: application to acetylcholinesterase inhibition. J Med Chem. 2004 Oct 21;47(22):5492-500. DME1UNY RU https://pubmed.ncbi.nlm.nih.gov/15481986 DMXE1LC DI DMXE1LC DMXE1LC DN 3-[2-(3,5-Dimethoxy-phenyl)-vinyl]-furan DMXE1LC MI TTI84H7 DMXE1LC MN Cytochrome P450 1B1 (CYP1B1) DMXE1LC MT DTT DMXE1LC MA Inhibitor DMXE1LC RN Design, synthesis, and discovery of novel trans-stilbene analogues as potent and selective human cytochrome P450 1B1 inhibitors. J Med Chem. 2002 Jan 3;45(1):160-4. DMXE1LC RU https://pubmed.ncbi.nlm.nih.gov/11754588 DM5EJLD DI DM5EJLD DM5EJLD DN 3-[2-(5-Chloro-2-thienyl)pyridin-4-yl]phenol DM5EJLD MI TTIWB6L DM5EJLD MN Estradiol 17 beta-dehydrogenase 1 (17-beta-HSD1) DM5EJLD MT DTT DM5EJLD MA Inhibitor DM5EJLD RN Novel estrone mimetics with high 17beta-HSD1 inhibitory activity. Bioorg Med Chem. 2010 May 15;18(10):3494-505. DM5EJLD RU https://pubmed.ncbi.nlm.nih.gov/20413314 DMJB1KL DI DMJB1KL DMJB1KL DN 3-[2-(N,N,N-trimethylammonium)ethoxy]pyridine DMJB1KL MI TT4H1MQ DMJB1KL MN Neuronal acetylcholine receptor alpha-4 (CHRNA4) DMJB1KL MT DTT DMJB1KL MA Inhibitor DMJB1KL RN Aryloxyethylamines: binding at alpha7 nicotinic acetylcholine receptors. Bioorg Med Chem Lett. 2006 Aug 15;16(16):4283-6. DMJB1KL RU https://pubmed.ncbi.nlm.nih.gov/16765047 DMJB1KL DI DMJB1KL DMJB1KL DN 3-[2-(N,N,N-trimethylammonium)ethoxy]pyridine DMJB1KL MI TT5KPZR DMJB1KL MN Neuronal acetylcholine receptor beta-2 (CHRNB2) DMJB1KL MT DTT DMJB1KL MA Inhibitor DMJB1KL RN Aryloxyethylamines: binding at alpha7 nicotinic acetylcholine receptors. Bioorg Med Chem Lett. 2006 Aug 15;16(16):4283-6. DMJB1KL RU https://pubmed.ncbi.nlm.nih.gov/16765047 DMLX9SI DI DMLX9SI DMLX9SI DN 3-[3-(2-Hydroxy-ethoxy)-phenyl]-1H-quinolin-2-one DMLX9SI MI TTSFWA7 DMLX9SI MN Plasmodium CDK Pfmrk (Malaria Pfmrk) DMLX9SI MT DTT DMLX9SI MA Inhibitor DMLX9SI RN A three-dimensional in silico pharmacophore model for inhibition of Plasmodium falciparum cyclin-dependent kinases and discovery of different class... J Med Chem. 2004 Oct 21;47(22):5418-26. DMLX9SI RU https://pubmed.ncbi.nlm.nih.gov/15481979 DM60YGF DI DM60YGF DM60YGF DN 3-[3-(3-benzyloxy-pyridin-2-yl)-ureido]-benzamide DM60YGF MI TTL2ADK DM60YGF MN Rotamase A (PPIA) DM60YGF MT DTT DM60YGF MA Inhibitor DM60YGF RN Structure-based design, synthesis, and biological evaluation of novel inhibitors of human cyclophilin A. J Med Chem. 2006 Feb 9;49(3):900-10. DM60YGF RU https://pubmed.ncbi.nlm.nih.gov/16451056 DMNC6W9 DI DMNC6W9 DMNC6W9 DN 3-[3-(4-hydroxyphenyl)isoxazol-5-yl]phenol DMNC6W9 MI TTIWB6L DMNC6W9 MN Estradiol 17 beta-dehydrogenase 1 (17-beta-HSD1) DMNC6W9 MT DTT DMNC6W9 MA Inhibitor DMNC6W9 RN Design, synthesis and biological evaluation of bis(hydroxyphenyl) azoles as potent and selective non-steroidal inhibitors of 17beta-hydroxysteroid ... Bioorg Med Chem. 2008 Jun 15;16(12):6423-35. DMNC6W9 RU https://pubmed.ncbi.nlm.nih.gov/18514529 DMTLJMF DI DMTLJMF DMTLJMF DN 3-[3-(4-Imidazol-1-yl-phenoxy)-propyl]-pyridine DMTLJMF MI TTXV4FI DMTLJMF MN Albendazole monooxygenase (CYP3A4) DMTLJMF MT DTT DMTLJMF MA Inhibitor DMTLJMF RN Imidazole derivatives as new potent and selective 20-HETE synthase inhibitors. Bioorg Med Chem Lett. 2004 Jan 19;14(2):333-6. DMTLJMF RU https://pubmed.ncbi.nlm.nih.gov/14698153 DMTLJMF DI DMTLJMF DMTLJMF DN 3-[3-(4-Imidazol-1-yl-phenoxy)-propyl]-pyridine DMTLJMF MI TTVG215 DMTLJMF MN Debrisoquine 4-hydroxylase (CYP2D6) DMTLJMF MT DTT DMTLJMF MA Inhibitor DMTLJMF RN Imidazole derivatives as new potent and selective 20-HETE synthase inhibitors. Bioorg Med Chem Lett. 2004 Jan 19;14(2):333-6. DMTLJMF RU https://pubmed.ncbi.nlm.nih.gov/14698153 DM8NRJQ DI DM8NRJQ DM8NRJQ DN 3-[3-(4-Methoxybenzyl)naphthalen-2-yl]pyridine DM8NRJQ MI TTXV4FI DM8NRJQ MN Albendazole monooxygenase (CYP3A4) DM8NRJQ MT DTT DM8NRJQ MA Inhibitor DM8NRJQ RN Novel aldosterone synthase inhibitors with extended carbocyclic skeleton by a combined ligand-based and structure-based drug design approach. J Med Chem. 2008 Oct 9;51(19):6138-49. DM8NRJQ RU https://pubmed.ncbi.nlm.nih.gov/18763754 DM8NRJQ DI DM8NRJQ DM8NRJQ DN 3-[3-(4-Methoxybenzyl)naphthalen-2-yl]pyridine DM8NRJQ MI TTIQUX7 DM8NRJQ MN Steroid 11-beta-hydroxylase (CYP11B1) DM8NRJQ MT DTT DM8NRJQ MA Inhibitor DM8NRJQ RN Novel aldosterone synthase inhibitors with extended carbocyclic skeleton by a combined ligand-based and structure-based drug design approach. J Med Chem. 2008 Oct 9;51(19):6138-49. DM8NRJQ RU https://pubmed.ncbi.nlm.nih.gov/18763754 DMPVXTB DI DMPVXTB DMPVXTB DN 3-[3-(benzylmethylamino)propoxy]xanthen-9-one DMPVXTB MI TT1RS9F DMPVXTB MN Acetylcholinesterase (AChE) DMPVXTB MT DTT DMPVXTB MA Inhibitor DMPVXTB RN Cholinesterase inhibitors: SAR and enzyme inhibitory activity of 3-[omega-(benzylmethylamino)alkoxy]xanthen-9-ones. Bioorg Med Chem. 2007 Jan 1;15(1):575-85. DMPVXTB RU https://pubmed.ncbi.nlm.nih.gov/17008100 DMPVXTB DI DMPVXTB DMPVXTB DN 3-[3-(benzylmethylamino)propoxy]xanthen-9-one DMPVXTB MI TTEB0GD DMPVXTB MN Cholinesterase (BCHE) DMPVXTB MT DTT DMPVXTB MA Inhibitor DMPVXTB RN Cholinesterase inhibitors: SAR and enzyme inhibitory activity of 3-[omega-(benzylmethylamino)alkoxy]xanthen-9-ones. Bioorg Med Chem. 2007 Jan 1;15(1):575-85. DMPVXTB RU https://pubmed.ncbi.nlm.nih.gov/17008100 DMDS8UJ DI DMDS8UJ DMDS8UJ DN 3-[3-Methyl-indan-(1E)-ylidenemethyl]-pyridine DMDS8UJ MI TTSZLWK DMDS8UJ MN Aromatase (CYP19A1) DMDS8UJ MT DTT DMDS8UJ MA Inhibitor DMDS8UJ RN Synthesis and evaluation of (pyridylmethylene)tetrahydronaphthalenes/-indanes and structurally modified derivatives: potent and selective inhibitor... J Med Chem. 2005 Mar 10;48(5):1563-75. DMDS8UJ RU https://pubmed.ncbi.nlm.nih.gov/15743198 DMTF520 DI DMTF520 DMTF520 DN 3-[3-Methyl-indan-(1Z)-ylidenemethyl]-pyridine DMTF520 MI TTSZLWK DMTF520 MN Aromatase (CYP19A1) DMTF520 MT DTT DMTF520 MA Inhibitor DMTF520 RN Synthesis and evaluation of (pyridylmethylene)tetrahydronaphthalenes/-indanes and structurally modified derivatives: potent and selective inhibitor... J Med Chem. 2005 Mar 10;48(5):1563-75. DMTF520 RU https://pubmed.ncbi.nlm.nih.gov/15743198 DMYEWA4 DI DMYEWA4 DMYEWA4 DN 3-[3-Phenyl-indan-(1E)-ylidenemethyl]-pyridine DMYEWA4 MI TTSZLWK DMYEWA4 MN Aromatase (CYP19A1) DMYEWA4 MT DTT DMYEWA4 MA Inhibitor DMYEWA4 RN Synthesis and evaluation of (pyridylmethylene)tetrahydronaphthalenes/-indanes and structurally modified derivatives: potent and selective inhibitor... J Med Chem. 2005 Mar 10;48(5):1563-75. DMYEWA4 RU https://pubmed.ncbi.nlm.nih.gov/15743198 DME86OK DI DME86OK DME86OK DN 3-[4-(4-Fluoro-phenoxy)-phenyl]-1H-pyrazole DME86OK MI TT84DRB DME86OK MN Voltage-gated sodium channel alpha Nav1.4 (SCN4A) DME86OK MT DTT DME86OK MA Inhibitor DME86OK RN 3-(4-phenoxyphenyl)pyrazoles: a novel class of sodium channel blockers. J Med Chem. 2004 Mar 11;47(6):1547-52. DME86OK RU https://pubmed.ncbi.nlm.nih.gov/14998340 DMIM5WE DI DMIM5WE DMIM5WE DN 3-[4-(4-Hydroxyphenyl)-1,3-oxazol-2-yl]phenol DMIM5WE MI TTIWB6L DMIM5WE MN Estradiol 17 beta-dehydrogenase 1 (17-beta-HSD1) DMIM5WE MT DTT DMIM5WE MA Inhibitor DMIM5WE RN Design, synthesis and biological evaluation of bis(hydroxyphenyl) azoles as potent and selective non-steroidal inhibitors of 17beta-hydroxysteroid ... Bioorg Med Chem. 2008 Jun 15;16(12):6423-35. DMIM5WE RU https://pubmed.ncbi.nlm.nih.gov/18514529 DM75F1Q DI DM75F1Q DM75F1Q DN 3-[4-(4-phenoxybenzoyl)phenyl]propanoic acid DM75F1Q MI TTT02K8 DM75F1Q MN Steroid 5-alpha-reductase 2 (SRD5A2) DM75F1Q MT DTT DM75F1Q MA Inhibitor DM75F1Q RN Novel 5alpha-reductase inhibitors: synthesis, structure-activity studies, and pharmacokinetic profile of phenoxybenzoylphenyl acetic acids. J Med Chem. 2006 Jan 26;49(2):748-59. DM75F1Q RU https://pubmed.ncbi.nlm.nih.gov/16420060 DMZCO83 DI DMZCO83 DMZCO83 DN 3-[4-(5-Chloro-2-thienyl)pyridin-2-yl]phenol DMZCO83 MI TTIWB6L DMZCO83 MN Estradiol 17 beta-dehydrogenase 1 (17-beta-HSD1) DMZCO83 MT DTT DMZCO83 MA Inhibitor DMZCO83 RN Novel estrone mimetics with high 17beta-HSD1 inhibitory activity. Bioorg Med Chem. 2010 May 15;18(10):3494-505. DMZCO83 RU https://pubmed.ncbi.nlm.nih.gov/20413314 DMZPULH DI DMZPULH DMZPULH DN 3-[4-(benzylmethylamino)butoxy]xanthen-9-one DMZPULH MI TT1RS9F DMZPULH MN Acetylcholinesterase (AChE) DMZPULH MT DTT DMZPULH MA Inhibitor DMZPULH RN Cholinesterase inhibitors: SAR and enzyme inhibitory activity of 3-[omega-(benzylmethylamino)alkoxy]xanthen-9-ones. Bioorg Med Chem. 2007 Jan 1;15(1):575-85. DMZPULH RU https://pubmed.ncbi.nlm.nih.gov/17008100 DMZPULH DI DMZPULH DMZPULH DN 3-[4-(benzylmethylamino)butoxy]xanthen-9-one DMZPULH MI TTEB0GD DMZPULH MN Cholinesterase (BCHE) DMZPULH MT DTT DMZPULH MA Inhibitor DMZPULH RN Cholinesterase inhibitors: SAR and enzyme inhibitory activity of 3-[omega-(benzylmethylamino)alkoxy]xanthen-9-ones. Bioorg Med Chem. 2007 Jan 1;15(1):575-85. DMZPULH RU https://pubmed.ncbi.nlm.nih.gov/17008100 DM0XD6T DI DM0XD6T DM0XD6T DN 3-[4-Chloro-indan-(1E)-ylidenemethyl]-pyridine DM0XD6T MI TTSZLWK DM0XD6T MN Aromatase (CYP19A1) DM0XD6T MT DTT DM0XD6T MA Inhibitor DM0XD6T RN Synthesis and evaluation of (pyridylmethylene)tetrahydronaphthalenes/-indanes and structurally modified derivatives: potent and selective inhibitor... J Med Chem. 2005 Mar 10;48(5):1563-75. DM0XD6T RU https://pubmed.ncbi.nlm.nih.gov/15743198 DM0XD6T DI DM0XD6T DM0XD6T DN 3-[4-Chloro-indan-(1E)-ylidenemethyl]-pyridine DM0XD6T MI TTIQUX7 DM0XD6T MN Steroid 11-beta-hydroxylase (CYP11B1) DM0XD6T MT DTT DM0XD6T MA Inhibitor DM0XD6T RN Synthesis and evaluation of (pyridylmethylene)tetrahydronaphthalenes/-indanes and structurally modified derivatives: potent and selective inhibitor... J Med Chem. 2005 Mar 10;48(5):1563-75. DM0XD6T RU https://pubmed.ncbi.nlm.nih.gov/15743198 DMMDIB9 DI DMMDIB9 DMMDIB9 DN 3-[4-Chloro-indan-(1Z)-ylidenemethyl]-pyridine DMMDIB9 MI TTSZLWK DMMDIB9 MN Aromatase (CYP19A1) DMMDIB9 MT DTT DMMDIB9 MA Inhibitor DMMDIB9 RN Synthesis and evaluation of (pyridylmethylene)tetrahydronaphthalenes/-indanes and structurally modified derivatives: potent and selective inhibitor... J Med Chem. 2005 Mar 10;48(5):1563-75. DMMDIB9 RU https://pubmed.ncbi.nlm.nih.gov/15743198 DMMDIB9 DI DMMDIB9 DMMDIB9 DN 3-[4-Chloro-indan-(1Z)-ylidenemethyl]-pyridine DMMDIB9 MI TTIQUX7 DMMDIB9 MN Steroid 11-beta-hydroxylase (CYP11B1) DMMDIB9 MT DTT DMMDIB9 MA Inhibitor DMMDIB9 RN Synthesis and evaluation of (pyridylmethylene)tetrahydronaphthalenes/-indanes and structurally modified derivatives: potent and selective inhibitor... J Med Chem. 2005 Mar 10;48(5):1563-75. DMMDIB9 RU https://pubmed.ncbi.nlm.nih.gov/15743198 DMZS20Y DI DMZS20Y DMZS20Y DN 3-[4-Fluoro-indan-(1E)-ylidenemethyl]-pyridine DMZS20Y MI TTSZLWK DMZS20Y MN Aromatase (CYP19A1) DMZS20Y MT DTT DMZS20Y MA Inhibitor DMZS20Y RN Synthesis and evaluation of (pyridylmethylene)tetrahydronaphthalenes/-indanes and structurally modified derivatives: potent and selective inhibitor... J Med Chem. 2005 Mar 10;48(5):1563-75. DMZS20Y RU https://pubmed.ncbi.nlm.nih.gov/15743198 DMZS20Y DI DMZS20Y DMZS20Y DN 3-[4-Fluoro-indan-(1E)-ylidenemethyl]-pyridine DMZS20Y MI TTIQUX7 DMZS20Y MN Steroid 11-beta-hydroxylase (CYP11B1) DMZS20Y MT DTT DMZS20Y MA Inhibitor DMZS20Y RN Synthesis and evaluation of (pyridylmethylene)tetrahydronaphthalenes/-indanes and structurally modified derivatives: potent and selective inhibitor... J Med Chem. 2005 Mar 10;48(5):1563-75. DMZS20Y RU https://pubmed.ncbi.nlm.nih.gov/15743198 DMPS340 DI DMPS340 DMPS340 DN 3-[4-Fluoro-indan-(1Z)-ylidenemethyl]-pyridine DMPS340 MI TTSZLWK DMPS340 MN Aromatase (CYP19A1) DMPS340 MT DTT DMPS340 MA Inhibitor DMPS340 RN Synthesis and evaluation of (pyridylmethylene)tetrahydronaphthalenes/-indanes and structurally modified derivatives: potent and selective inhibitor... J Med Chem. 2005 Mar 10;48(5):1563-75. DMPS340 RU https://pubmed.ncbi.nlm.nih.gov/15743198 DMPS340 DI DMPS340 DMPS340 DN 3-[4-Fluoro-indan-(1Z)-ylidenemethyl]-pyridine DMPS340 MI TTRA5BZ DMPS340 MN Steroid 17-alpha-monooxygenase (S17AH) DMPS340 MT DTT DMPS340 MA Inhibitor DMPS340 RN Synthesis and evaluation of (pyridylmethylene)tetrahydronaphthalenes/-indanes and structurally modified derivatives: potent and selective inhibitor... J Med Chem. 2005 Mar 10;48(5):1563-75. DMPS340 RU https://pubmed.ncbi.nlm.nih.gov/15743198 DMJN93U DI DMJN93U DMJN93U DN 3-[4-Methyl-indan-(1E)-ylidenemethyl]-pyridine DMJN93U MI TTSZLWK DMJN93U MN Aromatase (CYP19A1) DMJN93U MT DTT DMJN93U MA Inhibitor DMJN93U RN Synthesis and evaluation of (pyridylmethylene)tetrahydronaphthalenes/-indanes and structurally modified derivatives: potent and selective inhibitor... J Med Chem. 2005 Mar 10;48(5):1563-75. DMJN93U RU https://pubmed.ncbi.nlm.nih.gov/15743198 DMJN93U DI DMJN93U DMJN93U DN 3-[4-Methyl-indan-(1E)-ylidenemethyl]-pyridine DMJN93U MI TTIQUX7 DMJN93U MN Steroid 11-beta-hydroxylase (CYP11B1) DMJN93U MT DTT DMJN93U MA Inhibitor DMJN93U RN Synthesis and evaluation of (pyridylmethylene)tetrahydronaphthalenes/-indanes and structurally modified derivatives: potent and selective inhibitor... J Med Chem. 2005 Mar 10;48(5):1563-75. DMJN93U RU https://pubmed.ncbi.nlm.nih.gov/15743198 DMNILXG DI DMNILXG DMNILXG DN 3-[4-Methyl-indan-(1Z)-ylidenemethyl]-pyridine DMNILXG MI TTSZLWK DMNILXG MN Aromatase (CYP19A1) DMNILXG MT DTT DMNILXG MA Inhibitor DMNILXG RN Synthesis and evaluation of (pyridylmethylene)tetrahydronaphthalenes/-indanes and structurally modified derivatives: potent and selective inhibitor... J Med Chem. 2005 Mar 10;48(5):1563-75. DMNILXG RU https://pubmed.ncbi.nlm.nih.gov/15743198 DMYZIG3 DI DMYZIG3 DMYZIG3 DN 3-[5-(3,4-Difluorophenyl)-2-thienyl]phenol DMYZIG3 MI TTIWB6L DMYZIG3 MN Estradiol 17 beta-dehydrogenase 1 (17-beta-HSD1) DMYZIG3 MT DTT DMYZIG3 MA Inhibitor DMYZIG3 RN New insights into the SAR and binding modes of bis(hydroxyphenyl)thiophenes and -benzenes: influence of additional substituents on 17beta-hydroxyst... J Med Chem. 2009 Nov 12;52(21):6724-43. DMYZIG3 RU https://pubmed.ncbi.nlm.nih.gov/19831396 DMD5QOW DI DMD5QOW DMD5QOW DN 3-[5-(3-Fluorophenyl)-2-thienyl]phenol DMD5QOW MI TTIWB6L DMD5QOW MN Estradiol 17 beta-dehydrogenase 1 (17-beta-HSD1) DMD5QOW MT DTT DMD5QOW MA Inhibitor DMD5QOW RN New insights into the SAR and binding modes of bis(hydroxyphenyl)thiophenes and -benzenes: influence of additional substituents on 17beta-hydroxyst... J Med Chem. 2009 Nov 12;52(21):6724-43. DMD5QOW RU https://pubmed.ncbi.nlm.nih.gov/19831396 DM1QKNU DI DM1QKNU DM1QKNU DN 3-[5-(3-nitrophenyl)thiophen-2-yl]propanoic acid DM1QKNU MI TTFBNVI DM1QKNU MN Aldose reductase (AKR1B1) DM1QKNU MT DTT DM1QKNU MA Inhibitor DM1QKNU RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DM1QKNU RU https://pubmed.ncbi.nlm.nih.gov/10592235 DMYZ2U0 DI DMYZ2U0 DMYZ2U0 DN 3-[5-(4-Fluorophenyl)-2-thienyl]phenol DMYZ2U0 MI TTIWB6L DMYZ2U0 MN Estradiol 17 beta-dehydrogenase 1 (17-beta-HSD1) DMYZ2U0 MT DTT DMYZ2U0 MA Inhibitor DMYZ2U0 RN New insights into the SAR and binding modes of bis(hydroxyphenyl)thiophenes and -benzenes: influence of additional substituents on 17beta-hydroxyst... J Med Chem. 2009 Nov 12;52(21):6724-43. DMYZ2U0 RU https://pubmed.ncbi.nlm.nih.gov/19831396 DM4TFMA DI DM4TFMA DM4TFMA DN 3-[5-(4-hydroxyphenyl)-1,3-oxazol-2-yl]phenol DM4TFMA MI TTIWB6L DM4TFMA MN Estradiol 17 beta-dehydrogenase 1 (17-beta-HSD1) DM4TFMA MT DTT DM4TFMA MA Inhibitor DM4TFMA RN Design, synthesis, biological evaluation and pharmacokinetics of bis(hydroxyphenyl) substituted azoles, thiophenes, benzenes, and aza-benzenes as p... J Med Chem. 2008 Nov 13;51(21):6725-39. DM4TFMA RU https://pubmed.ncbi.nlm.nih.gov/18855374 DM2IXO0 DI DM2IXO0 DM2IXO0 DN 3-[5-(4-hydroxyphenyl)-1,3-thiazol-2-yl]phenol DM2IXO0 MI TTIWB6L DM2IXO0 MN Estradiol 17 beta-dehydrogenase 1 (17-beta-HSD1) DM2IXO0 MT DTT DM2IXO0 MA Inhibitor DM2IXO0 RN New insights into the SAR and binding modes of bis(hydroxyphenyl)thiophenes and -benzenes: influence of additional substituents on 17beta-hydroxyst... J Med Chem. 2009 Nov 12;52(21):6724-43. DM2IXO0 RU https://pubmed.ncbi.nlm.nih.gov/19831396 DMAMOJE DI DMAMOJE DMAMOJE DN 3-[5-(4-Hydroxyphenyl)-2-thienyl]-5-methylphenol DMAMOJE MI TTIWB6L DMAMOJE MN Estradiol 17 beta-dehydrogenase 1 (17-beta-HSD1) DMAMOJE MT DTT DMAMOJE MA Inhibitor DMAMOJE RN New insights into the SAR and binding modes of bis(hydroxyphenyl)thiophenes and -benzenes: influence of additional substituents on 17beta-hydroxyst... J Med Chem. 2009 Nov 12;52(21):6724-43. DMAMOJE RU https://pubmed.ncbi.nlm.nih.gov/19831396 DMSFW9T DI DMSFW9T DMSFW9T DN 3-[5-(4-hydroxyphenyl)-2-thienyl]phenol DMSFW9T MI TTIWB6L DMSFW9T MN Estradiol 17 beta-dehydrogenase 1 (17-beta-HSD1) DMSFW9T MT DTT DMSFW9T MA Inhibitor DMSFW9T RN New insights into the SAR and binding modes of bis(hydroxyphenyl)thiophenes and -benzenes: influence of additional substituents on 17beta-hydroxyst... J Med Chem. 2009 Nov 12;52(21):6724-43. DMSFW9T RU https://pubmed.ncbi.nlm.nih.gov/19831396 DM40GJ8 DI DM40GJ8 DM40GJ8 DN 3-[5-(4-Hydroxyphenyl)-3-thienyl]phenol DM40GJ8 MI TTXV4FI DM40GJ8 MN Albendazole monooxygenase (CYP3A4) DM40GJ8 MT DTT DM40GJ8 MA Inhibitor DM40GJ8 RN Design, synthesis, biological evaluation and pharmacokinetics of bis(hydroxyphenyl) substituted azoles, thiophenes, benzenes, and aza-benzenes as p... J Med Chem. 2008 Nov 13;51(21):6725-39. DM40GJ8 RU https://pubmed.ncbi.nlm.nih.gov/18855374 DM40GJ8 DI DM40GJ8 DM40GJ8 DN 3-[5-(4-Hydroxyphenyl)-3-thienyl]phenol DM40GJ8 MI TTIWB6L DM40GJ8 MN Estradiol 17 beta-dehydrogenase 1 (17-beta-HSD1) DM40GJ8 MT DTT DM40GJ8 MA Inhibitor DM40GJ8 RN Design, synthesis, biological evaluation and pharmacokinetics of bis(hydroxyphenyl) substituted azoles, thiophenes, benzenes, and aza-benzenes as p... J Med Chem. 2008 Nov 13;51(21):6725-39. DM40GJ8 RU https://pubmed.ncbi.nlm.nih.gov/18855374 DMQZ0A7 DI DMQZ0A7 DMQZ0A7 DN 3-[5-(benzylmethylamino)pentyloxy]xanthen-9-one DMQZ0A7 MI TT1RS9F DMQZ0A7 MN Acetylcholinesterase (AChE) DMQZ0A7 MT DTT DMQZ0A7 MA Inhibitor DMQZ0A7 RN Cholinesterase inhibitors: SAR and enzyme inhibitory activity of 3-[omega-(benzylmethylamino)alkoxy]xanthen-9-ones. Bioorg Med Chem. 2007 Jan 1;15(1):575-85. DMQZ0A7 RU https://pubmed.ncbi.nlm.nih.gov/17008100 DMQZ0A7 DI DMQZ0A7 DMQZ0A7 DN 3-[5-(benzylmethylamino)pentyloxy]xanthen-9-one DMQZ0A7 MI TTEB0GD DMQZ0A7 MN Cholinesterase (BCHE) DMQZ0A7 MT DTT DMQZ0A7 MA Inhibitor DMQZ0A7 RN Cholinesterase inhibitors: SAR and enzyme inhibitory activity of 3-[omega-(benzylmethylamino)alkoxy]xanthen-9-ones. Bioorg Med Chem. 2007 Jan 1;15(1):575-85. DMQZ0A7 RU https://pubmed.ncbi.nlm.nih.gov/17008100 DMUEVAQ DI DMUEVAQ DMUEVAQ DN 3-[5-Bromo-indan-(1E)-ylidenemethyl]-pyridine DMUEVAQ MI TTSZLWK DMUEVAQ MN Aromatase (CYP19A1) DMUEVAQ MT DTT DMUEVAQ MA Inhibitor DMUEVAQ RN Synthesis and evaluation of (pyridylmethylene)tetrahydronaphthalenes/-indanes and structurally modified derivatives: potent and selective inhibitor... J Med Chem. 2005 Mar 10;48(5):1563-75. DMUEVAQ RU https://pubmed.ncbi.nlm.nih.gov/15743198 DMUEVAQ DI DMUEVAQ DMUEVAQ DN 3-[5-Bromo-indan-(1E)-ylidenemethyl]-pyridine DMUEVAQ MI TTIQUX7 DMUEVAQ MN Steroid 11-beta-hydroxylase (CYP11B1) DMUEVAQ MT DTT DMUEVAQ MA Inhibitor DMUEVAQ RN Synthesis and evaluation of (pyridylmethylene)tetrahydronaphthalenes/-indanes and structurally modified derivatives: potent and selective inhibitor... J Med Chem. 2005 Mar 10;48(5):1563-75. DMUEVAQ RU https://pubmed.ncbi.nlm.nih.gov/15743198 DMCXSIH DI DMCXSIH DMCXSIH DN 3-[5-Bromo-indan-(1Z)-ylidenemethyl]-pyridine DMCXSIH MI TTSZLWK DMCXSIH MN Aromatase (CYP19A1) DMCXSIH MT DTT DMCXSIH MA Inhibitor DMCXSIH RN Synthesis and evaluation of (pyridylmethylene)tetrahydronaphthalenes/-indanes and structurally modified derivatives: potent and selective inhibitor... J Med Chem. 2005 Mar 10;48(5):1563-75. DMCXSIH RU https://pubmed.ncbi.nlm.nih.gov/15743198 DMCXSIH DI DMCXSIH DMCXSIH DN 3-[5-Bromo-indan-(1Z)-ylidenemethyl]-pyridine DMCXSIH MI TTIQUX7 DMCXSIH MN Steroid 11-beta-hydroxylase (CYP11B1) DMCXSIH MT DTT DMCXSIH MA Inhibitor DMCXSIH RN Synthesis and evaluation of (pyridylmethylene)tetrahydronaphthalenes/-indanes and structurally modified derivatives: potent and selective inhibitor... J Med Chem. 2005 Mar 10;48(5):1563-75. DMCXSIH RU https://pubmed.ncbi.nlm.nih.gov/15743198 DM8TWLO DI DM8TWLO DM8TWLO DN 3-[5-Chloro-indan-(1E)-ylidenemethyl]-pyridine DM8TWLO MI TTSZLWK DM8TWLO MN Aromatase (CYP19A1) DM8TWLO MT DTT DM8TWLO MA Inhibitor DM8TWLO RN Synthesis and evaluation of (pyridylmethylene)tetrahydronaphthalenes/-indanes and structurally modified derivatives: potent and selective inhibitor... J Med Chem. 2005 Mar 10;48(5):1563-75. DM8TWLO RU https://pubmed.ncbi.nlm.nih.gov/15743198 DM8TWLO DI DM8TWLO DM8TWLO DN 3-[5-Chloro-indan-(1E)-ylidenemethyl]-pyridine DM8TWLO MI TTIQUX7 DM8TWLO MN Steroid 11-beta-hydroxylase (CYP11B1) DM8TWLO MT DTT DM8TWLO MA Inhibitor DM8TWLO RN Synthesis and evaluation of (pyridylmethylene)tetrahydronaphthalenes/-indanes and structurally modified derivatives: potent and selective inhibitor... J Med Chem. 2005 Mar 10;48(5):1563-75. DM8TWLO RU https://pubmed.ncbi.nlm.nih.gov/15743198 DMN60YG DI DMN60YG DMN60YG DN 3-[5-Chloro-indan-(1Z)-ylidenemethyl]-pyridine DMN60YG MI TTSZLWK DMN60YG MN Aromatase (CYP19A1) DMN60YG MT DTT DMN60YG MA Inhibitor DMN60YG RN Synthesis and evaluation of (pyridylmethylene)tetrahydronaphthalenes/-indanes and structurally modified derivatives: potent and selective inhibitor... J Med Chem. 2005 Mar 10;48(5):1563-75. DMN60YG RU https://pubmed.ncbi.nlm.nih.gov/15743198 DMN60YG DI DMN60YG DMN60YG DN 3-[5-Chloro-indan-(1Z)-ylidenemethyl]-pyridine DMN60YG MI TTIQUX7 DMN60YG MN Steroid 11-beta-hydroxylase (CYP11B1) DMN60YG MT DTT DMN60YG MA Inhibitor DMN60YG RN Synthesis and evaluation of (pyridylmethylene)tetrahydronaphthalenes/-indanes and structurally modified derivatives: potent and selective inhibitor... J Med Chem. 2005 Mar 10;48(5):1563-75. DMN60YG RU https://pubmed.ncbi.nlm.nih.gov/15743198 DMLJQZS DI DMLJQZS DMLJQZS DN 3-[5-Ethoxy-indan-(1E)-ylidenemethyl]-pyridine DMLJQZS MI TTSZLWK DMLJQZS MN Aromatase (CYP19A1) DMLJQZS MT DTT DMLJQZS MA Inhibitor DMLJQZS RN Synthesis and evaluation of (pyridylmethylene)tetrahydronaphthalenes/-indanes and structurally modified derivatives: potent and selective inhibitor... J Med Chem. 2005 Mar 10;48(5):1563-75. DMLJQZS RU https://pubmed.ncbi.nlm.nih.gov/15743198 DMLJQZS DI DMLJQZS DMLJQZS DN 3-[5-Ethoxy-indan-(1E)-ylidenemethyl]-pyridine DMLJQZS MI TTIQUX7 DMLJQZS MN Steroid 11-beta-hydroxylase (CYP11B1) DMLJQZS MT DTT DMLJQZS MA Inhibitor DMLJQZS RN Synthesis and evaluation of (pyridylmethylene)tetrahydronaphthalenes/-indanes and structurally modified derivatives: potent and selective inhibitor... J Med Chem. 2005 Mar 10;48(5):1563-75. DMLJQZS RU https://pubmed.ncbi.nlm.nih.gov/15743198 DMMTUON DI DMMTUON DMMTUON DN 3-[5-Ethoxy-indan-(1Z)-ylidenemethyl]-pyridine DMMTUON MI TTSZLWK DMMTUON MN Aromatase (CYP19A1) DMMTUON MT DTT DMMTUON MA Inhibitor DMMTUON RN Synthesis and evaluation of (pyridylmethylene)tetrahydronaphthalenes/-indanes and structurally modified derivatives: potent and selective inhibitor... J Med Chem. 2005 Mar 10;48(5):1563-75. DMMTUON RU https://pubmed.ncbi.nlm.nih.gov/15743198 DMMTUON DI DMMTUON DMMTUON DN 3-[5-Ethoxy-indan-(1Z)-ylidenemethyl]-pyridine DMMTUON MI TTIQUX7 DMMTUON MN Steroid 11-beta-hydroxylase (CYP11B1) DMMTUON MT DTT DMMTUON MA Inhibitor DMMTUON RN Synthesis and evaluation of (pyridylmethylene)tetrahydronaphthalenes/-indanes and structurally modified derivatives: potent and selective inhibitor... J Med Chem. 2005 Mar 10;48(5):1563-75. DMMTUON RU https://pubmed.ncbi.nlm.nih.gov/15743198 DMWSFIR DI DMWSFIR DMWSFIR DN 3-[5-Fluoro-indan-(1E)-ylidenemethyl]-pyridine DMWSFIR MI TTSZLWK DMWSFIR MN Aromatase (CYP19A1) DMWSFIR MT DTT DMWSFIR MA Inhibitor DMWSFIR RN Synthesis and evaluation of (pyridylmethylene)tetrahydronaphthalenes/-indanes and structurally modified derivatives: potent and selective inhibitor... J Med Chem. 2005 Mar 10;48(5):1563-75. DMWSFIR RU https://pubmed.ncbi.nlm.nih.gov/15743198 DMWSFIR DI DMWSFIR DMWSFIR DN 3-[5-Fluoro-indan-(1E)-ylidenemethyl]-pyridine DMWSFIR MI TTIQUX7 DMWSFIR MN Steroid 11-beta-hydroxylase (CYP11B1) DMWSFIR MT DTT DMWSFIR MA Inhibitor DMWSFIR RN Synthesis and evaluation of (pyridylmethylene)tetrahydronaphthalenes/-indanes and structurally modified derivatives: potent and selective inhibitor... J Med Chem. 2005 Mar 10;48(5):1563-75. DMWSFIR RU https://pubmed.ncbi.nlm.nih.gov/15743198 DMN42I5 DI DMN42I5 DMN42I5 DN 3-[5-Fluoro-indan-(1Z)-ylidenemethyl]-pyridine DMN42I5 MI TTSZLWK DMN42I5 MN Aromatase (CYP19A1) DMN42I5 MT DTT DMN42I5 MA Inhibitor DMN42I5 RN Synthesis and evaluation of (pyridylmethylene)tetrahydronaphthalenes/-indanes and structurally modified derivatives: potent and selective inhibitor... J Med Chem. 2005 Mar 10;48(5):1563-75. DMN42I5 RU https://pubmed.ncbi.nlm.nih.gov/15743198 DMN42I5 DI DMN42I5 DMN42I5 DN 3-[5-Fluoro-indan-(1Z)-ylidenemethyl]-pyridine DMN42I5 MI TTIQUX7 DMN42I5 MN Steroid 11-beta-hydroxylase (CYP11B1) DMN42I5 MT DTT DMN42I5 MA Inhibitor DMN42I5 RN Synthesis and evaluation of (pyridylmethylene)tetrahydronaphthalenes/-indanes and structurally modified derivatives: potent and selective inhibitor... J Med Chem. 2005 Mar 10;48(5):1563-75. DMN42I5 RU https://pubmed.ncbi.nlm.nih.gov/15743198 DM9AW5U DI DM9AW5U DM9AW5U DN 3-[5-Methoxy-indan-(1E)-ylidenemethyl]-pyridine DM9AW5U MI TTSZLWK DM9AW5U MN Aromatase (CYP19A1) DM9AW5U MT DTT DM9AW5U MA Inhibitor DM9AW5U RN Synthesis and evaluation of (pyridylmethylene)tetrahydronaphthalenes/-indanes and structurally modified derivatives: potent and selective inhibitor... J Med Chem. 2005 Mar 10;48(5):1563-75. DM9AW5U RU https://pubmed.ncbi.nlm.nih.gov/15743198 DM9AW5U DI DM9AW5U DM9AW5U DN 3-[5-Methoxy-indan-(1E)-ylidenemethyl]-pyridine DM9AW5U MI TTIQUX7 DM9AW5U MN Steroid 11-beta-hydroxylase (CYP11B1) DM9AW5U MT DTT DM9AW5U MA Inhibitor DM9AW5U RN Synthesis and evaluation of (pyridylmethylene)tetrahydronaphthalenes/-indanes and structurally modified derivatives: potent and selective inhibitor... J Med Chem. 2005 Mar 10;48(5):1563-75. DM9AW5U RU https://pubmed.ncbi.nlm.nih.gov/15743198 DMB3XYE DI DMB3XYE DMB3XYE DN 3-[5-Methoxy-indan-(1Z)-ylidenemethyl]-pyridine DMB3XYE MI TTSZLWK DMB3XYE MN Aromatase (CYP19A1) DMB3XYE MT DTT DMB3XYE MA Inhibitor DMB3XYE RN Synthesis and evaluation of (pyridylmethylene)tetrahydronaphthalenes/-indanes and structurally modified derivatives: potent and selective inhibitor... J Med Chem. 2005 Mar 10;48(5):1563-75. DMB3XYE RU https://pubmed.ncbi.nlm.nih.gov/15743198 DMB3XYE DI DMB3XYE DMB3XYE DN 3-[5-Methoxy-indan-(1Z)-ylidenemethyl]-pyridine DMB3XYE MI TTIQUX7 DMB3XYE MN Steroid 11-beta-hydroxylase (CYP11B1) DMB3XYE MT DTT DMB3XYE MA Inhibitor DMB3XYE RN Synthesis and evaluation of (pyridylmethylene)tetrahydronaphthalenes/-indanes and structurally modified derivatives: potent and selective inhibitor... J Med Chem. 2005 Mar 10;48(5):1563-75. DMB3XYE RU https://pubmed.ncbi.nlm.nih.gov/15743198 DMLTZ5F DI DMLTZ5F DMLTZ5F DN 3-[6-(5-Chloro-2-thienyl)pyridin-2-yl]phenol DMLTZ5F MI TTIWB6L DMLTZ5F MN Estradiol 17 beta-dehydrogenase 1 (17-beta-HSD1) DMLTZ5F MT DTT DMLTZ5F MA Inhibitor DMLTZ5F RN Novel estrone mimetics with high 17beta-HSD1 inhibitory activity. Bioorg Med Chem. 2010 May 15;18(10):3494-505. DMLTZ5F RU https://pubmed.ncbi.nlm.nih.gov/20413314 DM89RN3 DI DM89RN3 DM89RN3 DN 3-[6-(benzylmethylamino)hexyloxy]xanthen-9-one DM89RN3 MI TT1RS9F DM89RN3 MN Acetylcholinesterase (AChE) DM89RN3 MT DTT DM89RN3 MA Inhibitor DM89RN3 RN Cholinesterase inhibitors: SAR and enzyme inhibitory activity of 3-[omega-(benzylmethylamino)alkoxy]xanthen-9-ones. Bioorg Med Chem. 2007 Jan 1;15(1):575-85. DM89RN3 RU https://pubmed.ncbi.nlm.nih.gov/17008100 DM89RN3 DI DM89RN3 DM89RN3 DN 3-[6-(benzylmethylamino)hexyloxy]xanthen-9-one DM89RN3 MI TTEB0GD DM89RN3 MN Cholinesterase (BCHE) DM89RN3 MT DTT DM89RN3 MA Inhibitor DM89RN3 RN Cholinesterase inhibitors: SAR and enzyme inhibitory activity of 3-[omega-(benzylmethylamino)alkoxy]xanthen-9-ones. Bioorg Med Chem. 2007 Jan 1;15(1):575-85. DM89RN3 RU https://pubmed.ncbi.nlm.nih.gov/17008100 DMHT6FX DI DMHT6FX DMHT6FX DN 3-[6-Methoxy-indan-(1E)-ylidenemethyl]-pyridine DMHT6FX MI TTSZLWK DMHT6FX MN Aromatase (CYP19A1) DMHT6FX MT DTT DMHT6FX MA Inhibitor DMHT6FX RN Synthesis and evaluation of (pyridylmethylene)tetrahydronaphthalenes/-indanes and structurally modified derivatives: potent and selective inhibitor... J Med Chem. 2005 Mar 10;48(5):1563-75. DMHT6FX RU https://pubmed.ncbi.nlm.nih.gov/15743198 DMG76LS DI DMG76LS DMG76LS DN 3-[6-Methyl-indan-(1E)-ylidenemethyl]-pyridine DMG76LS MI TTSZLWK DMG76LS MN Aromatase (CYP19A1) DMG76LS MT DTT DMG76LS MA Inhibitor DMG76LS RN Synthesis and evaluation of (pyridylmethylene)tetrahydronaphthalenes/-indanes and structurally modified derivatives: potent and selective inhibitor... J Med Chem. 2005 Mar 10;48(5):1563-75. DMG76LS RU https://pubmed.ncbi.nlm.nih.gov/15743198 DMKOB2T DI DMKOB2T DMKOB2T DN 3-[6-Methyl-indan-(1Z)-ylidenemethyl]-pyridine DMKOB2T MI TTSZLWK DMKOB2T MN Aromatase (CYP19A1) DMKOB2T MT DTT DMKOB2T MA Inhibitor DMKOB2T RN Synthesis and evaluation of (pyridylmethylene)tetrahydronaphthalenes/-indanes and structurally modified derivatives: potent and selective inhibitor... J Med Chem. 2005 Mar 10;48(5):1563-75. DMKOB2T RU https://pubmed.ncbi.nlm.nih.gov/15743198 DMMD3G6 DI DMMD3G6 DMMD3G6 DN 3-[7-(benzylmethylamino)-heptyloxy]xanthen-9-one DMMD3G6 MI TT1RS9F DMMD3G6 MN Acetylcholinesterase (AChE) DMMD3G6 MT DTT DMMD3G6 MA Inhibitor DMMD3G6 RN Cholinesterase inhibitors: SAR and enzyme inhibitory activity of 3-[omega-(benzylmethylamino)alkoxy]xanthen-9-ones. Bioorg Med Chem. 2007 Jan 1;15(1):575-85. DMMD3G6 RU https://pubmed.ncbi.nlm.nih.gov/17008100 DMMD3G6 DI DMMD3G6 DMMD3G6 DN 3-[7-(benzylmethylamino)-heptyloxy]xanthen-9-one DMMD3G6 MI TTEB0GD DMMD3G6 MN Cholinesterase (BCHE) DMMD3G6 MT DTT DMMD3G6 MA Inhibitor DMMD3G6 RN Cholinesterase inhibitors: SAR and enzyme inhibitory activity of 3-[omega-(benzylmethylamino)alkoxy]xanthen-9-ones. Bioorg Med Chem. 2007 Jan 1;15(1):575-85. DMMD3G6 RU https://pubmed.ncbi.nlm.nih.gov/17008100 DM7IHUK DI DM7IHUK DM7IHUK DN 3-[7'-(Methoxy)-napht-2'-yl]-quinuclidine-2-ene DM7IHUK MI TTFQEO5 DM7IHUK MN Squalene synthetase (FDFT1) DM7IHUK MT DTT DM7IHUK MA Inhibitor DM7IHUK RN Quinuclidine derivatives as potential antiparasitics. Antimicrob Agents Chemother. 2007 Nov;51(11):4049-61. DM7IHUK RU https://pubmed.ncbi.nlm.nih.gov/17709461 DMVWIQ2 DI DMVWIQ2 DMVWIQ2 DN 3-[7-Methoxy-indan-(1E)-ylidenemethyl]-pyridine DMVWIQ2 MI TTSZLWK DMVWIQ2 MN Aromatase (CYP19A1) DMVWIQ2 MT DTT DMVWIQ2 MA Inhibitor DMVWIQ2 RN Synthesis and evaluation of (pyridylmethylene)tetrahydronaphthalenes/-indanes and structurally modified derivatives: potent and selective inhibitor... J Med Chem. 2005 Mar 10;48(5):1563-75. DMVWIQ2 RU https://pubmed.ncbi.nlm.nih.gov/15743198 DMVWIQ2 DI DMVWIQ2 DMVWIQ2 DN 3-[7-Methoxy-indan-(1E)-ylidenemethyl]-pyridine DMVWIQ2 MI TTIQUX7 DMVWIQ2 MN Steroid 11-beta-hydroxylase (CYP11B1) DMVWIQ2 MT DTT DMVWIQ2 MA Inhibitor DMVWIQ2 RN Synthesis and evaluation of (pyridylmethylene)tetrahydronaphthalenes/-indanes and structurally modified derivatives: potent and selective inhibitor... J Med Chem. 2005 Mar 10;48(5):1563-75. DMVWIQ2 RU https://pubmed.ncbi.nlm.nih.gov/15743198 DM31WYF DI DM31WYF DM31WYF DN 3-[8-(benzylmethylamino)octyloxy]xanthen-9-one DM31WYF MI TT1RS9F DM31WYF MN Acetylcholinesterase (AChE) DM31WYF MT DTT DM31WYF MA Inhibitor DM31WYF RN Cholinesterase inhibitors: SAR and enzyme inhibitory activity of 3-[omega-(benzylmethylamino)alkoxy]xanthen-9-ones. Bioorg Med Chem. 2007 Jan 1;15(1):575-85. DM31WYF RU https://pubmed.ncbi.nlm.nih.gov/17008100 DM31WYF DI DM31WYF DM31WYF DN 3-[8-(benzylmethylamino)octyloxy]xanthen-9-one DM31WYF MI TTEB0GD DM31WYF MN Cholinesterase (BCHE) DM31WYF MT DTT DM31WYF MA Inhibitor DM31WYF RN Cholinesterase inhibitors: SAR and enzyme inhibitory activity of 3-[omega-(benzylmethylamino)alkoxy]xanthen-9-ones. Bioorg Med Chem. 2007 Jan 1;15(1):575-85. DM31WYF RU https://pubmed.ncbi.nlm.nih.gov/17008100 DMZSBU5 DI DMZSBU5 DMZSBU5 DN 3-[9-(benzylmethylamino)nonyloxy]xanthen-9-one DMZSBU5 MI TTEB0GD DMZSBU5 MN Cholinesterase (BCHE) DMZSBU5 MT DTT DMZSBU5 MA Inhibitor DMZSBU5 RN Cholinesterase inhibitors: SAR and enzyme inhibitory activity of 3-[omega-(benzylmethylamino)alkoxy]xanthen-9-ones. Bioorg Med Chem. 2007 Jan 1;15(1):575-85. DMZSBU5 RU https://pubmed.ncbi.nlm.nih.gov/17008100 DMLZ5F1 DI DMLZ5F1 DMLZ5F1 DN 3-{[2-(2-phenylethyl)phenoxy]methyl}pyridine DMLZ5F1 MI TTSQIFT DMLZ5F1 MN 5-HT 1A receptor (HTR1A) DMLZ5F1 MT DTT DMLZ5F1 MA Inhibitor DMLZ5F1 RN Arylmethyloxyphenyl derivatives: small molecules displaying P-glycoprotein inhibition. J Med Chem. 2006 Nov 2;49(22):6607-13. DMLZ5F1 RU https://pubmed.ncbi.nlm.nih.gov/17064079 DMLZ5F1 DI DMLZ5F1 DMLZ5F1 DN 3-{[2-(2-phenylethyl)phenoxy]methyl}pyridine DMLZ5F1 MI TTEX248 DMLZ5F1 MN Dopamine D2 receptor (D2R) DMLZ5F1 MT DTT DMLZ5F1 MA Inhibitor DMLZ5F1 RN Arylmethyloxyphenyl derivatives: small molecules displaying P-glycoprotein inhibition. J Med Chem. 2006 Nov 2;49(22):6607-13. DMLZ5F1 RU https://pubmed.ncbi.nlm.nih.gov/17064079 DMUH9PF DI DMUH9PF DMUH9PF DN 3-{3-[(aminosulfonyl)oxy]benzoyl}phenyl sulfamate DMUH9PF MI TTHM0R1 DMUH9PF MN Steryl-sulfatase (STS) DMUH9PF MT DTT DMUH9PF MA Inhibitor DMUH9PF RN 4,4'-Benzophenone-O,O'-disulfamate: a potent inhibitor of steroid sulfatase. Bioorg Med Chem Lett. 2002 Aug 19;12(16):2093-5. DMUH9PF RU https://pubmed.ncbi.nlm.nih.gov/12127511 DMGS2X7 DI DMGS2X7 DMGS2X7 DN 3-{4-[(aminosulfonyl)oxy]benzoyl}phenyl sulfamate DMGS2X7 MI TTHM0R1 DMGS2X7 MN Steryl-sulfatase (STS) DMGS2X7 MT DTT DMGS2X7 MA Inhibitor DMGS2X7 RN 4,4'-Benzophenone-O,O'-disulfamate: a potent inhibitor of steroid sulfatase. Bioorg Med Chem Lett. 2002 Aug 19;12(16):2093-5. DMGS2X7 RU https://pubmed.ncbi.nlm.nih.gov/12127511 DMT80IF DI DMT80IF DMT80IF DN 3570-0208 DMT80IF MI TT5Y4EM DMT80IF MN N-formyl peptide receptor (FPR1) DMT80IF MT DTT DMT80IF MA Antagonist DMT80IF RN Discovery of selective probes and antagonists for G-protein-coupled receptors FPR/FPRL1 and GPR30. Curr Top Med Chem. 2009;9(13):1227-36. DMT80IF RU https://pubmed.ncbi.nlm.nih.gov/19807662 DMGO2D7 DI DMGO2D7 DMGO2D7 DN 3-acetyl-11-keto-beta-boswellic acid DMGO2D7 MI TTN7BL9 DMGO2D7 MN Corticosteroid 11-beta-dehydrogenase 1 (HSD11B1) DMGO2D7 MT DTT DMGO2D7 MA Inhibitor DMGO2D7 RN 11beta-Hydroxysteroid dehydrogenase 1 inhibiting constituents from Eriobotrya japonica revealed by bioactivity-guided isolation and computational a... Bioorg Med Chem. 2010 Feb 15;18(4):1507-15. DMGO2D7 RU https://pubmed.ncbi.nlm.nih.gov/20100662 DMGO2D7 DI DMGO2D7 DMGO2D7 DN 3-acetyl-11-keto-beta-boswellic acid DMGO2D7 MI TT9H85R DMGO2D7 MN Corticosteroid 11-beta-dehydrogenase 2 (HSD11B2) DMGO2D7 MT DTT DMGO2D7 MA Inhibitor DMGO2D7 RN 11beta-Hydroxysteroid dehydrogenase 1 inhibiting constituents from Eriobotrya japonica revealed by bioactivity-guided isolation and computational a... Bioorg Med Chem. 2010 Feb 15;18(4):1507-15. DMGO2D7 RU https://pubmed.ncbi.nlm.nih.gov/20100662 DMHRZ2V DI DMHRZ2V DMHRZ2V DN 3-acetyl-11-keto-ursolic acid DMHRZ2V MI TTN7BL9 DMHRZ2V MN Corticosteroid 11-beta-dehydrogenase 1 (HSD11B1) DMHRZ2V MT DTT DMHRZ2V MA Inhibitor DMHRZ2V RN 11beta-Hydroxysteroid dehydrogenase 1 inhibiting constituents from Eriobotrya japonica revealed by bioactivity-guided isolation and computational a... Bioorg Med Chem. 2010 Feb 15;18(4):1507-15. DMHRZ2V RU https://pubmed.ncbi.nlm.nih.gov/20100662 DM01WBD DI DM01WBD DM01WBD DN 3-acetyl-7-hydroxy-2H-chromen-2-one DM01WBD MI TT6804T DM01WBD MN MIF messenger RNA (MIF mRNA) DM01WBD MT DTT DM01WBD MA Inhibitor DM01WBD RN Discovery of human macrophage migration inhibitory factor (MIF)-CD74 antagonists via virtual screening. J Med Chem. 2009 Jan 22;52(2):416-24. DM01WBD RU https://pubmed.ncbi.nlm.nih.gov/19090668 DMCNX34 DI DMCNX34 DMCNX34 DN 3alpha-(1'-Methyl-2'-Indolecarbonyloxy)-tropane DMCNX34 MI TTPC4TU DMCNX34 MN 5-HT 3A receptor (HTR3A) DMCNX34 MT DTT DMCNX34 MA Inhibitor DMCNX34 RN Synthesis of heteroaromatic tropeines and heterogeneous binding to glycine receptors. Bioorg Med Chem. 2009 Oct 1;17(19):6872-8. DMCNX34 RU https://pubmed.ncbi.nlm.nih.gov/19726200 DM3BRYJ DI DM3BRYJ DM3BRYJ DN 3alpha-(2'-Indolecarbonyloxy)-nortropane DM3BRYJ MI TTPC4TU DM3BRYJ MN 5-HT 3A receptor (HTR3A) DM3BRYJ MT DTT DM3BRYJ MA Inhibitor DM3BRYJ RN Synthesis of heteroaromatic tropeines and heterogeneous binding to glycine receptors. Bioorg Med Chem. 2009 Oct 1;17(19):6872-8. DM3BRYJ RU https://pubmed.ncbi.nlm.nih.gov/19726200 DMBUZWQ DI DMBUZWQ DMBUZWQ DN 3alpha-(bis-chloro-phenylmethoxy)tropane DMBUZWQ MI TTVBI8W DMBUZWQ MN Dopamine transporter (DAT) DMBUZWQ MT DTT DMBUZWQ MA Inhibitor DMBUZWQ RN Structure-activity relationship studies on a novel series of (S)-2beta-substituted 3alpha-[bis(4-fluoro- or 4-chlorophenyl)methoxy]tropane analogue... J Med Chem. 2006 Oct 19;49(21):6391-9. DMBUZWQ RU https://pubmed.ncbi.nlm.nih.gov/17034144 DMBUZWQ DI DMBUZWQ DMBUZWQ DN 3alpha-(bis-chloro-phenylmethoxy)tropane DMBUZWQ MI TTZ9SOR DMBUZWQ MN Muscarinic acetylcholine receptor M1 (CHRM1) DMBUZWQ MT DTT DMBUZWQ MA Inhibitor DMBUZWQ RN Structure-activity relationship studies on a novel series of (S)-2beta-substituted 3alpha-[bis(4-fluoro- or 4-chlorophenyl)methoxy]tropane analogue... J Med Chem. 2006 Oct 19;49(21):6391-9. DMBUZWQ RU https://pubmed.ncbi.nlm.nih.gov/17034144 DMBUZWQ DI DMBUZWQ DMBUZWQ DN 3alpha-(bis-chloro-phenylmethoxy)tropane DMBUZWQ MI TTAWNKZ DMBUZWQ MN Norepinephrine transporter (NET) DMBUZWQ MT DTT DMBUZWQ MA Inhibitor DMBUZWQ RN Structure-activity relationship studies on a novel series of (S)-2beta-substituted 3alpha-[bis(4-fluoro- or 4-chlorophenyl)methoxy]tropane analogue... J Med Chem. 2006 Oct 19;49(21):6391-9. DMBUZWQ RU https://pubmed.ncbi.nlm.nih.gov/17034144 DMBUZWQ DI DMBUZWQ DMBUZWQ DN 3alpha-(bis-chloro-phenylmethoxy)tropane DMBUZWQ MI TT3ROYC DMBUZWQ MN Serotonin transporter (SERT) DMBUZWQ MT DTT DMBUZWQ MA Inhibitor DMBUZWQ RN Structure-activity relationship studies on a novel series of (S)-2beta-substituted 3alpha-[bis(4-fluoro- or 4-chlorophenyl)methoxy]tropane analogue... J Med Chem. 2006 Oct 19;49(21):6391-9. DMBUZWQ RU https://pubmed.ncbi.nlm.nih.gov/17034144 DM3ZR7A DI DM3ZR7A DM3ZR7A DN 3alpha,24-dihydroxyolean-12-en-27-oic acid DM3ZR7A MI TTELIN2 DM3ZR7A MN PTPN1 messenger RNA (PTPN1 mRNA) DM3ZR7A MT DTT DM3ZR7A MA Inhibitor DM3ZR7A RN Protein tyrosine phosphatase 1B inhibitory activity of triterpenes isolated from Astilbe koreana. Bioorg Med Chem Lett. 2006 Jun 15;16(12):3273-6. DM3ZR7A RU https://pubmed.ncbi.nlm.nih.gov/16580200 DMV6OPB DI DMV6OPB DMV6OPB DN 3alpha-Hydroxyurs-12-en-28-oic Acid DMV6OPB MI TTZHY6R DMV6OPB MN Glycogen phosphorylase muscle form (GP) DMV6OPB MT DTT DMV6OPB MA Inhibitor DMV6OPB RN Naturally occurring pentacyclic triterpenes as inhibitors of glycogen phosphorylase: synthesis, structure-activity relationships, and X-ray crystal... J Med Chem. 2008 Jun 26;51(12):3540-54. DMV6OPB RU https://pubmed.ncbi.nlm.nih.gov/18517260 DM4M6LR DI DM4M6LR DM4M6LR DN 3alpha-O-trans-p-coumaroyl-7-labden-15-oic acid DM4M6LR MI TTIU7X1 DM4M6LR MN Herpes simplex virus DNA polymerase UL30 (HSV UL30) DM4M6LR MT DTT DM4M6LR MA Inhibitor DM4M6LR RN Harbinatic acid, a novel and potent DNA polymerase beta inhibitor from Hardwickia binata. J Nat Prod. 1999 Jul;62(7):1000-2. DM4M6LR RU https://pubmed.ncbi.nlm.nih.gov/10425125 DMO5IJA DI DMO5IJA DMO5IJA DN 3-alpha-Phenylmethoxy-3-beta-phenyl-nortropane DMO5IJA MI TTVBI8W DMO5IJA MN Dopamine transporter (DAT) DMO5IJA MT DTT DMO5IJA MA Inhibitor DMO5IJA RN Synthesis and monoamine transporter affinity of 3alpha-arylmethoxy-3beta-arylnortropanes. Bioorg Med Chem Lett. 2009 Dec 15;19(24):6865-8. DMO5IJA RU https://pubmed.ncbi.nlm.nih.gov/19896846 DMO5IJA DI DMO5IJA DMO5IJA DN 3-alpha-Phenylmethoxy-3-beta-phenyl-nortropane DMO5IJA MI TT3ROYC DMO5IJA MN Serotonin transporter (SERT) DMO5IJA MT DTT DMO5IJA MA Inhibitor DMO5IJA RN Synthesis and monoamine transporter affinity of 3alpha-arylmethoxy-3beta-arylnortropanes. Bioorg Med Chem Lett. 2009 Dec 15;19(24):6865-8. DMO5IJA RU https://pubmed.ncbi.nlm.nih.gov/19896846 DMKGIQ1 DI DMKGIQ1 DMKGIQ1 DN 3-Amino-1-(2-amino-5-methoxy-phenyl)-propan-1-one DMKGIQ1 MI TTSQIFT DMKGIQ1 MN 5-HT 1A receptor (HTR1A) DMKGIQ1 MT DTT DMKGIQ1 MA Inhibitor DMKGIQ1 RN Synthesis and evaluation of phenyl- and benzoylpiperazines as potential serotonergic agents. J Med Chem. 1986 May;29(5):630-4. DMKGIQ1 RU https://pubmed.ncbi.nlm.nih.gov/3701781 DMKGIQ1 DI DMKGIQ1 DMKGIQ1 DN 3-Amino-1-(2-amino-5-methoxy-phenyl)-propan-1-one DMKGIQ1 MI TT6MSOK DMKGIQ1 MN 5-HT 1D receptor (HTR1D) DMKGIQ1 MT DTT DMKGIQ1 MA Inhibitor DMKGIQ1 RN Synthesis and evaluation of phenyl- and benzoylpiperazines as potential serotonergic agents. J Med Chem. 1986 May;29(5):630-4. DMKGIQ1 RU https://pubmed.ncbi.nlm.nih.gov/3701781 DMKGIQ1 DI DMKGIQ1 DMKGIQ1 DN 3-Amino-1-(2-amino-5-methoxy-phenyl)-propan-1-one DMKGIQ1 MI TTJQOD7 DMKGIQ1 MN 5-HT 2A receptor (HTR2A) DMKGIQ1 MT DTT DMKGIQ1 MA Inhibitor DMKGIQ1 RN Synthesis and evaluation of phenyl- and benzoylpiperazines as potential serotonergic agents. J Med Chem. 1986 May;29(5):630-4. DMKGIQ1 RU https://pubmed.ncbi.nlm.nih.gov/3701781 DMF3DBE DI DMF3DBE DMF3DBE DN 3-amino-2-(benzylideneamino)-5-mercaptophenol DMF3DBE MI TTGX0HR DMF3DBE MN Bacterial DNA ligase (Bact ligA) DMF3DBE MT DTT DMF3DBE MA Inhibitor DMF3DBE RN Identification and validation of human DNA ligase inhibitors using computer-aided drug design. J Med Chem. 2008 Aug 14;51(15):4553-62. DMF3DBE RU https://pubmed.ncbi.nlm.nih.gov/18630893 DMV4XGT DI DMV4XGT DMV4XGT DN 3-Amino-3-(methoxycarbonyl)-1,5-pentandioic acid DMV4XGT MI TTHI19T DMV4XGT MN Staphylococcus Beta-lactamase (Stap-coc blaZ) DMV4XGT MT DTT DMV4XGT MA Inhibitor DMV4XGT RN Discovery of novel lipophilic inhibitors of OXA-10 enzyme (class D beta-lactamase) by screening amino analogs and homologs of citrate and isocitrate. Bioorg Med Chem Lett. 2009 Jul 1;19(13):3593-7. DMV4XGT RU https://pubmed.ncbi.nlm.nih.gov/19467869 DM60K7H DI DM60K7H DM60K7H DN 3-amino-3-demethoxythiocolchicine DM60K7H MI TT1MPAY DM60K7H MN GABA(A) receptor alpha-1 (GABRA1) DM60K7H MT DTT DM60K7H MA Inhibitor DM60K7H RN 3-demethoxy-3-glycosylaminothiocolchicines: Synthesis of a new class of putative muscle relaxant compounds. J Med Chem. 2006 Sep 7;49(18):5571-7. DM60K7H RU https://pubmed.ncbi.nlm.nih.gov/16942030 DM60K7H DI DM60K7H DM60K7H DN 3-amino-3-demethoxythiocolchicine DM60K7H MI TTZA1NY DM60K7H MN GABA(A) receptor beta-2 (GABRB2) DM60K7H MT DTT DM60K7H MA Inhibitor DM60K7H RN 3-demethoxy-3-glycosylaminothiocolchicines: Synthesis of a new class of putative muscle relaxant compounds. J Med Chem. 2006 Sep 7;49(18):5571-7. DM60K7H RU https://pubmed.ncbi.nlm.nih.gov/16942030 DM60K7H DI DM60K7H DM60K7H DN 3-amino-3-demethoxythiocolchicine DM60K7H MI TT06RH5 DM60K7H MN GABA(A) receptor gamma-2 (GABRG2) DM60K7H MT DTT DM60K7H MA Inhibitor DM60K7H RN 3-demethoxy-3-glycosylaminothiocolchicines: Synthesis of a new class of putative muscle relaxant compounds. J Med Chem. 2006 Sep 7;49(18):5571-7. DM60K7H RU https://pubmed.ncbi.nlm.nih.gov/16942030 DM60K7H DI DM60K7H DM60K7H DN 3-amino-3-demethoxythiocolchicine DM60K7H MI TTNJYV2 DM60K7H MN Gamma-aminobutyric acid receptor (GAR) DM60K7H MT DTT DM60K7H MA Inhibitor DM60K7H RN 3-demethoxy-3-glycosylaminothiocolchicines: Synthesis of a new class of putative muscle relaxant compounds. J Med Chem. 2006 Sep 7;49(18):5571-7. DM60K7H RU https://pubmed.ncbi.nlm.nih.gov/16942030 DMJ7Y3H DI DMJ7Y3H DMJ7Y3H DN 3'-amino-4-(1,1-dimethyl-heptyl)-biphenyl-2-ol DMJ7Y3H MI TT6OEDT DMJ7Y3H MN Cannabinoid receptor 1 (CB1) DMJ7Y3H MT DTT DMJ7Y3H MA Inhibitor DMJ7Y3H RN Biaryl cannabinoid mimetics--synthesis and structure-activity relationship. Bioorg Med Chem Lett. 2007 Jul 1;17(13):3652-6. DMJ7Y3H RU https://pubmed.ncbi.nlm.nih.gov/17507224 DMJ7Y3H DI DMJ7Y3H DMJ7Y3H DN 3'-amino-4-(1,1-dimethyl-heptyl)-biphenyl-2-ol DMJ7Y3H MI TTMSFAW DMJ7Y3H MN Cannabinoid receptor 2 (CB2) DMJ7Y3H MT DTT DMJ7Y3H MA Inhibitor DMJ7Y3H RN Biaryl cannabinoid mimetics--synthesis and structure-activity relationship. Bioorg Med Chem Lett. 2007 Jul 1;17(13):3652-6. DMJ7Y3H RU https://pubmed.ncbi.nlm.nih.gov/17507224 DMIS3LN DI DMIS3LN DMIS3LN DN 3-Amino-4'-amino-trans-stilbene DMIS3LN MI TTSZLWK DMIS3LN MN Aromatase (CYP19A1) DMIS3LN MT DTT DMIS3LN MA Inhibitor DMIS3LN RN Design, synthesis, and biological evaluation of resveratrol analogues as aromatase and quinone reductase 2 inhibitors for chemoprevention of cancer. Bioorg Med Chem. 2010 Jul 15;18(14):5352-66. DMIS3LN RU https://pubmed.ncbi.nlm.nih.gov/20558073 DM5Z0O6 DI DM5Z0O6 DM5Z0O6 DN 3-Amino-4-Oxybenzyl-2-Butanone DM5Z0O6 MI TTF2LRI DM5Z0O6 MN Cathepsin B (CTSB) DM5Z0O6 MT DTT DM5Z0O6 MA Inhibitor DM5Z0O6 RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DM5Z0O6 RU https://pubmed.ncbi.nlm.nih.gov/17139284 DM2U9RY DI DM2U9RY DM2U9RY DN 3-amino-5-(4-chlorophenyl)thiophene-2-carboxamide DM2U9RY MI TTJ3E9X DM2U9RY MN Inhibitor of nuclear factor kappa-B kinase beta (IKKB) DM2U9RY MT DTT DM2U9RY MA Inhibitor DM2U9RY RN Evolution of the thienopyridine class of inhibitors of IkappaB kinase-beta: part I: hit-to-lead strategies. J Med Chem. 2006 May 18;49(10):2898-908. DM2U9RY RU https://pubmed.ncbi.nlm.nih.gov/16686533 DMONHFR DI DMONHFR DMONHFR DN 3-amino-5-(4-octylphenyl)pentanoic acid DMONHFR MI TT9JZCK DMONHFR MN Sphingosine-1-phosphate receptor 1 (S1PR1) DMONHFR MT DTT DMONHFR MA Inhibitor DMONHFR RN S1P receptor mediated activity of FTY720 phosphate mimics. Bioorg Med Chem Lett. 2010 Mar 1;20(5):1485-7. DMONHFR RU https://pubmed.ncbi.nlm.nih.gov/20153186 DM6Y2KW DI DM6Y2KW DM6Y2KW DN 3-amino-5-(furan-2-yl)biphenyl-2,4-dicarbonitrile DM6Y2KW MI TTEAID7 DM6Y2KW MN Trypanosoma Cruzipain (Trypano CYSP) DM6Y2KW MT DTT DM6Y2KW MA Inhibitor DM6Y2KW RN Quantitative analyses of aggregation, autofluorescence, and reactivity artifacts in a screen for inhibitors of a thiol protease. J Med Chem. 2010 Jan 14;53(1):37-51. DM6Y2KW RU https://pubmed.ncbi.nlm.nih.gov/19908840 DMP2K1A DI DMP2K1A DMP2K1A DN 3-Amino-5,6-dihydro-2H-benzo[f]quinazolin-1-one DMP2K1A MI TTU6BFZ DMP2K1A MN Candida Thymidylate synthase (Candi TMP1) DMP2K1A MT DTT DMP2K1A MA Inhibitor DMP2K1A RN Benzoquinazoline inhibitors of thymidylate synthase: enzyme inhibitory activity and cytotoxicity of some sulfonamidobenzoylglutamate and related de... J Med Chem. 1993 Oct 29;36(22):3464-71. DMP2K1A RU https://pubmed.ncbi.nlm.nih.gov/8230138 DMHDFZE DI DMHDFZE DMHDFZE DN 3-Amino-5-Phenylpentane DMHDFZE MI TTDZN01 DMHDFZE MN Cathepsin K (CTSK) DMHDFZE MT DTT DMHDFZE MA Inhibitor DMHDFZE RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMHDFZE RU https://pubmed.ncbi.nlm.nih.gov/17139284 DM0GJZM DI DM0GJZM DM0GJZM DN 3-aminoacetamido-4'-methylfuro[3,2-g]coumarin DM0GJZM MI TT3WG5C DM0GJZM MN Monoamine oxidase type A (MAO-A) DM0GJZM MT DTT DM0GJZM MA Inhibitor DM0GJZM RN A QSAR model for in silico screening of MAO-A inhibitors. Prediction, synthesis, and biological assay of novel coumarins. J Med Chem. 2006 Feb 9;49(3):1149-56. DM0GJZM RU https://pubmed.ncbi.nlm.nih.gov/16451079 DM5073T DI DM5073T DM5073T DN 3-AMINO-AZACYCLOTRIDECAN-2-ONE DM5073T MI TTGA1IV DM5073T MN Matrix metalloproteinase-8 (MMP-8) DM5073T MT DTT DM5073T MA Inhibitor DM5073T RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DM5073T RU https://pubmed.ncbi.nlm.nih.gov/10592235 DM7P3IZ DI DM7P3IZ DM7P3IZ DN 3-aminobenzamide DM7P3IZ MI TTVDSZ0 DM7P3IZ MN Poly [ADP-ribose] polymerase 1 (PARP1) DM7P3IZ MT DTT DM7P3IZ MA Inhibitor DM7P3IZ RN Diabetic endothelial dysfunction: the role of poly(ADP-ribose) polymerase activation. Nat Med. 2001 Jan;7(1):108-13. DM7P3IZ RU https://pubmed.ncbi.nlm.nih.gov/11135624 DME0TNA DI DME0TNA DME0TNA DN 3-Amino-benzenesulfonamide DME0TNA MI TTUNARX DME0TNA MN Carbonic anhydrase (CA) DME0TNA MT DTT DME0TNA MA Inhibitor DME0TNA RN Carbonic anhydrase inhibitors. Inhibition of the prokariotic beta and gamma-class enzymes from Archaea with sulfonamides. Bioorg Med Chem Lett. 2004 Dec 20;14(24):6001-6. DME0TNA RU https://pubmed.ncbi.nlm.nih.gov/15546717 DME0TNA DI DME0TNA DME0TNA DN 3-Amino-benzenesulfonamide DME0TNA MI TTANPDJ DME0TNA MN Carbonic anhydrase II (CA-II) DME0TNA MT DTT DME0TNA MA Inhibitor DME0TNA RN Carbonic anhydrase inhibitors. Inhibition of the membrane-bound human and bovine isozymes IV with sulfonamides. Bioorg Med Chem Lett. 2005 Feb 15;15(4):1149-54. DME0TNA RU https://pubmed.ncbi.nlm.nih.gov/15686931 DME0TNA DI DME0TNA DME0TNA DN 3-Amino-benzenesulfonamide DME0TNA MI TTZHA0O DME0TNA MN Carbonic anhydrase IV (CA-IV) DME0TNA MT DTT DME0TNA MA Inhibitor DME0TNA RN Carbonic anhydrase inhibitors. Inhibition of the membrane-bound human and bovine isozymes IV with sulfonamides. Bioorg Med Chem Lett. 2005 Feb 15;15(4):1149-54. DME0TNA RU https://pubmed.ncbi.nlm.nih.gov/15686931 DME0TNA DI DME0TNA DME0TNA DN 3-Amino-benzenesulfonamide DME0TNA MI TT2LVK8 DME0TNA MN Carbonic anhydrase IX (CA-IX) DME0TNA MT DTT DME0TNA MA Inhibitor DME0TNA RN Carbonic anhydrase inhibitors: inhibition of the transmembrane isozyme XIV with sulfonamides. Bioorg Med Chem Lett. 2005 Sep 1;15(17):3828-33. DME0TNA RU https://pubmed.ncbi.nlm.nih.gov/16039848 DME0TNA DI DME0TNA DME0TNA DN 3-Amino-benzenesulfonamide DME0TNA MI TTSYM0R DME0TNA MN Carbonic anhydrase XII (CA-XII) DME0TNA MT DTT DME0TNA MA Inhibitor DME0TNA RN Carbonic anhydrase inhibitors: inhibition of the transmembrane isozyme XIV with sulfonamides. Bioorg Med Chem Lett. 2005 Sep 1;15(17):3828-33. DME0TNA RU https://pubmed.ncbi.nlm.nih.gov/16039848 DME0TNA DI DME0TNA DME0TNA DN 3-Amino-benzenesulfonamide DME0TNA MI TTEYTKG DME0TNA MN Carbonic anhydrase XIV (CA-XIV) DME0TNA MT DTT DME0TNA MA Inhibitor DME0TNA RN Carbonic anhydrase inhibitors: inhibition of the transmembrane isozyme XIV with sulfonamides. Bioorg Med Chem Lett. 2005 Sep 1;15(17):3828-33. DME0TNA RU https://pubmed.ncbi.nlm.nih.gov/16039848 DMWOTD3 DI DMWOTD3 DMWOTD3 DN 3-amino-benzo[b]thiophene-2-carboxylic acid amide DMWOTD3 MI TTJ3E9X DMWOTD3 MN Inhibitor of nuclear factor kappa-B kinase beta (IKKB) DMWOTD3 MT DTT DMWOTD3 MA Inhibitor DMWOTD3 RN Evolution of the thienopyridine class of inhibitors of IkappaB kinase-beta: part I: hit-to-lead strategies. J Med Chem. 2006 May 18;49(10):2898-908. DMWOTD3 RU https://pubmed.ncbi.nlm.nih.gov/16686533 DML2UCP DI DML2UCP DML2UCP DN 3-aminobenzo[c][1,5]naphthyridin-6(5H)-one DML2UCP MI TTVDSZ0 DML2UCP MN Poly [ADP-ribose] polymerase 1 (PARP1) DML2UCP MT DTT DML2UCP MA Inhibitor DML2UCP RN Design, synthesis, and cytoprotective effect of 2-aminothiazole analogues as potent poly(ADP-ribose) polymerase-1 inhibitors. J Med Chem. 2009 Feb 12;52(3):718-25. DML2UCP RU https://pubmed.ncbi.nlm.nih.gov/19125579 DMTYXH1 DI DMTYXH1 DMTYXH1 DN 3-Aminomethyl-5-methyl-hexanoic acid DMTYXH1 MI TTFK1JQ DMTYXH1 MN Voltage-gated calcium channel alpha-2/delta-1 (CACNA2D1) DMTYXH1 MT DTT DMTYXH1 MA Inhibitor DMTYXH1 RN Enantioselective synthesis of PD144723: a potent stereospecific anticonvulsant, Bioorg. Med. Chem. Lett. 4(6):823-826 (1994). DMTYXH1 RU http://www.sciencedirect.com/science/article/pii/S0960894X01808556 DMTYXH1 DI DMTYXH1 DMTYXH1 DN 3-Aminomethyl-5-methyl-hexanoic acid DMTYXH1 MI TTU8P3M DMTYXH1 MN Voltage-gated calcium channel alpha-2/delta-2 (CACNA2D2) DMTYXH1 MT DTT DMTYXH1 MA Inhibitor DMTYXH1 RN Enantioselective synthesis of PD144723: a potent stereospecific anticonvulsant, Bioorg. Med. Chem. Lett. 4(6):823-826 (1994). DMTYXH1 RU http://www.sciencedirect.com/science/article/pii/S0960894X01808556 DMTYXH1 DI DMTYXH1 DMTYXH1 DN 3-Aminomethyl-5-methyl-hexanoic acid DMTYXH1 MI TTN7T29 DMTYXH1 MN Voltage-gated calcium channel alpha-2/delta-3 (CACNA2D3) DMTYXH1 MT DTT DMTYXH1 MA Inhibitor DMTYXH1 RN Enantioselective synthesis of PD144723: a potent stereospecific anticonvulsant, Bioorg. Med. Chem. Lett. 4(6):823-826 (1994). DMTYXH1 RU http://www.sciencedirect.com/science/article/pii/S0960894X01808556 DM5SQVC DI DM5SQVC DM5SQVC DN 3-ammoniopropane-1-sulfinate DM5SQVC MI TTDCVZW DM5SQVC MN Gamma-aminobutyric acid B receptor (GABBR) DM5SQVC MT DTT DM5SQVC MA Inhibitor DM5SQVC RN A study of 3-amino-N-hydroxypropanesulfonamide derivatives as potential GABAB agonists and their fragmentation to 3-aminopropanesulfinic acid, Bioorg. Med. Chem. Lett. 6(14):1709-1714 (1996). DM5SQVC RU http://www.sciencedirect.com/science/article/pii/0960894X96003071 DM5SQVC DI DM5SQVC DM5SQVC DN 3-ammoniopropane-1-sulfinate DM5SQVC MI TTNJYV2 DM5SQVC MN Gamma-aminobutyric acid receptor (GAR) DM5SQVC MT DTT DM5SQVC MA Inhibitor DM5SQVC RN A study of 3-amino-N-hydroxypropanesulfonamide derivatives as potential GABAB agonists and their fragmentation to 3-aminopropanesulfinic acid, Bioorg. Med. Chem. Lett. 6(14):1709-1714 (1996). DM5SQVC RU http://www.sciencedirect.com/science/article/pii/0960894X96003071 DM3VYNJ DI DM3VYNJ DM3VYNJ DN 3-anilino-5-benzylthio-1,2,4-triazole DM3VYNJ MI TTZL0OI DM3VYNJ MN Methionine aminopeptidase 2 (METAP2) DM3VYNJ MT DTT DM3VYNJ MA Inhibitor DM3VYNJ RN Highly potent inhibitors of methionine aminopeptidase-2 based on a 1,2,4-triazole pharmacophore. J Med Chem. 2007 Aug 9;50(16):3777-85. DM3VYNJ RU https://pubmed.ncbi.nlm.nih.gov/17636946 DM6KNMB DI DM6KNMB DM6KNMB DN 3-azageranylgeranyl diphosphate DM6KNMB MI TTIKWV4 DM6KNMB MN Geranyltranstransferase (FDPS) DM6KNMB MT DTT DM6KNMB MA Inhibitor DM6KNMB RN Inhibition of geranylgeranyl diphosphate synthase by bisphosphonates and diphosphates: a potential route to new bone antiresorption and antiparasitic agents. J Med Chem. 2002 May 23;45(11):2185-96. DM6KNMB RU https://pubmed.ncbi.nlm.nih.gov/12014956 DMU08MN DI DMU08MN DMU08MN DN 3'-Azido-3'-Deoxythymidine-5'-Monophosphate DMU08MN MI TT5B8AX DMU08MN MN Mycobacterium Thymidine monophosphate kinase (MycB tmk) DMU08MN MT DTT DMU08MN MA Inhibitor DMU08MN RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMU08MN RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMU08MN DI DMU08MN DMU08MN DN 3'-Azido-3'-Deoxythymidine-5'-Monophosphate DMU08MN MI DEOTVYU DMU08MN MN Thymidylate kinase (DTYMK) DMU08MN MT DME DMU08MN MA Metabolism DMU08MN RN Azidothymidine-triphosphate impairs mitochondrial dynamics by disrupting the quality control system. Redox Biol. 2017 Oct;13:407-417. DMU08MN RU https://www.ncbi.nlm.nih.gov/pubmed/?term=28683400 DMQXD0N DI DMQXD0N DMQXD0N DN 3-Benzenesulfinyl-heptanoic acid hydroxyamide DMQXD0N MI TTMX39J DMQXD0N MN Matrix metalloproteinase-1 (MMP-1) DMQXD0N MT DTT DMQXD0N MA Inhibitor DMQXD0N RN Hydroxamic acid derivatives as potent peptide deformylase inhibitors and antibacterial agents. J Med Chem. 2000 Jun 15;43(12):2324-31. DMQXD0N RU https://pubmed.ncbi.nlm.nih.gov/10882358 DM7XDCF DI DM7XDCF DM7XDCF DN 3-Benzenesulfonyl-heptanoic acid hydroxyamide DM7XDCF MI TTMX39J DM7XDCF MN Matrix metalloproteinase-1 (MMP-1) DM7XDCF MT DTT DM7XDCF MA Inhibitor DM7XDCF RN Hydroxamic acid derivatives as potent peptide deformylase inhibitors and antibacterial agents. J Med Chem. 2000 Jun 15;43(12):2324-31. DM7XDCF RU https://pubmed.ncbi.nlm.nih.gov/10882358 DM7XDCF DI DM7XDCF DM7XDCF DN 3-Benzenesulfonyl-heptanoic acid hydroxyamide DM7XDCF MI TTXZ0KQ DM7XDCF MN Matrix metalloproteinase-12 (MMP-12) DM7XDCF MT DTT DM7XDCF MA Inhibitor DM7XDCF RN Hydroxamic acid derivatives as potent peptide deformylase inhibitors and antibacterial agents. J Med Chem. 2000 Jun 15;43(12):2324-31. DM7XDCF RU https://pubmed.ncbi.nlm.nih.gov/10882358 DM7XDCF DI DM7XDCF DM7XDCF DN 3-Benzenesulfonyl-heptanoic acid hydroxyamide DM7XDCF MI TTHY57M DM7XDCF MN Matrix metalloproteinase-13 (MMP-13) DM7XDCF MT DTT DM7XDCF MA Inhibitor DM7XDCF RN Hydroxamic acid derivatives as potent peptide deformylase inhibitors and antibacterial agents. J Med Chem. 2000 Jun 15;43(12):2324-31. DM7XDCF RU https://pubmed.ncbi.nlm.nih.gov/10882358 DM7XDCF DI DM7XDCF DM7XDCF DN 3-Benzenesulfonyl-heptanoic acid hydroxyamide DM7XDCF MI TTMTWOS DM7XDCF MN Matrix metalloproteinase-7 (MMP-7) DM7XDCF MT DTT DM7XDCF MA Inhibitor DM7XDCF RN Hydroxamic acid derivatives as potent peptide deformylase inhibitors and antibacterial agents. J Med Chem. 2000 Jun 15;43(12):2324-31. DM7XDCF RU https://pubmed.ncbi.nlm.nih.gov/10882358 DMQXJA1 DI DMQXJA1 DMQXJA1 DN 3-Benzimidazol-2-ylhydroquinolin-2-one DMQXJA1 MI TTRLW2X DMQXJA1 MN Fibroblast growth factor receptor 1 (FGFR1) DMQXJA1 MT DTT DMQXJA1 MA Inhibitor DMQXJA1 RN Design, structure-activity relationships and in vivo characterization of 4-amino-3-benzimidazol-2-ylhydroquinolin-2-ones: a novel class of receptor... J Med Chem. 2009 Jan 22;52(2):278-92. DMQXJA1 RU https://pubmed.ncbi.nlm.nih.gov/19113866 DMQXJA1 DI DMQXJA1 DMQXJA1 DN 3-Benzimidazol-2-ylhydroquinolin-2-one DMQXJA1 MI TTI7421 DMQXJA1 MN Platelet-derived growth factor receptor beta (PDGFRB) DMQXJA1 MT DTT DMQXJA1 MA Inhibitor DMQXJA1 RN Design, structure-activity relationships and in vivo characterization of 4-amino-3-benzimidazol-2-ylhydroquinolin-2-ones: a novel class of receptor... J Med Chem. 2009 Jan 22;52(2):278-92. DMQXJA1 RU https://pubmed.ncbi.nlm.nih.gov/19113866 DMQXJA1 DI DMQXJA1 DMQXJA1 DN 3-Benzimidazol-2-ylhydroquinolin-2-one DMQXJA1 MI TTUTJGQ DMQXJA1 MN Vascular endothelial growth factor receptor 2 (KDR) DMQXJA1 MT DTT DMQXJA1 MA Inhibitor DMQXJA1 RN Design, structure-activity relationships and in vivo characterization of 4-amino-3-benzimidazol-2-ylhydroquinolin-2-ones: a novel class of receptor... J Med Chem. 2009 Jan 22;52(2):278-92. DMQXJA1 RU https://pubmed.ncbi.nlm.nih.gov/19113866 DMWLIK1 DI DMWLIK1 DMWLIK1 DN 3-benzofuran-2-yl-2-benzothiazol-2-yl-3-oxo-propanenitrile DMWLIK1 MI TTHGL48 DMWLIK1 MN AP endonuclease 1 (APEX1) DMWLIK1 MT DTT DMWLIK1 MA Inhibitor DMWLIK1 RN Development and evaluation of human AP endonuclease inhibitors in melanoma and glioma cell lines. Br J Cancer. 2011 Feb 15;104(4):653-63. DMWLIK1 RU https://pubmed.ncbi.nlm.nih.gov/21266972 DMHXRQL DI DMHXRQL DMHXRQL DN 3-benzoyl-1-pentyl-1,4-dihydroquinolin-4-one DMHXRQL MI TTMSFAW DMHXRQL MN Cannabinoid receptor 2 (CB2) DMHXRQL MT DTT DMHXRQL MA Inhibitor DMHXRQL RN Pharmacomodulations around the 4-oxo-1,4-dihydroquinoline-3-carboxamides, a class of potent CB2-selective cannabinoid receptor ligands: consequence... J Med Chem. 2007 Nov 1;50(22):5471-84. DMHXRQL RU https://pubmed.ncbi.nlm.nih.gov/17915849 DMAH4DG DI DMAH4DG DMAH4DG DN 3-Benzoyl-7-chloro-4-hydroxy-1H-quinolin-2-one DMAH4DG MI TTLD29N DMAH4DG MN Glutamate receptor ionotropic NMDA 1 (NMDAR1) DMAH4DG MT DTT DMAH4DG MA Inhibitor DMAH4DG RN Amino acid bioisosteres: design of 2-quinolone derivatives as glycine-site N-methyl-D-aspartate receptor antagonists, Bioorg. Med. Chem. Lett. 3(2):299-304 (1993). DMAH4DG RU http://www.sciencedirect.com/science/article/pii/S0960894X01808970 DMAH4DG DI DMAH4DG DMAH4DG DN 3-Benzoyl-7-chloro-4-hydroxy-1H-quinolin-2-one DMAH4DG MI TTKJEMQ DMAH4DG MN Glutamate receptor ionotropic NMDA 2A (NMDAR2A) DMAH4DG MT DTT DMAH4DG MA Inhibitor DMAH4DG RN Amino acid bioisosteres: design of 2-quinolone derivatives as glycine-site N-methyl-D-aspartate receptor antagonists, Bioorg. Med. Chem. Lett. 3(2):299-304 (1993). DMAH4DG RU http://www.sciencedirect.com/science/article/pii/S0960894X01808970 DMAH4DG DI DMAH4DG DMAH4DG DN 3-Benzoyl-7-chloro-4-hydroxy-1H-quinolin-2-one DMAH4DG MI TTN9D8E DMAH4DG MN Glutamate receptor ionotropic NMDA 2B (NMDAR2B) DMAH4DG MT DTT DMAH4DG MA Inhibitor DMAH4DG RN Amino acid bioisosteres: design of 2-quinolone derivatives as glycine-site N-methyl-D-aspartate receptor antagonists, Bioorg. Med. Chem. Lett. 3(2):299-304 (1993). DMAH4DG RU http://www.sciencedirect.com/science/article/pii/S0960894X01808970 DM25K86 DI DM25K86 DM25K86 DN 3-Benzoyl-N-hydroxy-benzamide DM25K86 MI TT2J34L DM25K86 MN Arachidonate 5-lipoxygenase (5-LOX) DM25K86 MT DTT DM25K86 MA Inhibitor DM25K86 RN Hydroxamic acid inhibitors of 5-lipoxygenase: quantitative structure-activity relationships. J Med Chem. 1990 Mar;33(3):992-8. DM25K86 RU https://pubmed.ncbi.nlm.nih.gov/2308149 DMNG0TY DI DMNG0TY DMNG0TY DN 3-benzyl-1-cyclohexylpyrrolidin-2-one DMNG0TY MI TTN7BL9 DMNG0TY MN Corticosteroid 11-beta-dehydrogenase 1 (HSD11B1) DMNG0TY MT DTT DMNG0TY MA Inhibitor DMNG0TY RN Discovery of orally active butyrolactam 11beta-HSD1 inhibitors. Bioorg Med Chem Lett. 2006 Nov 1;16(21):5555-60. DMNG0TY RU https://pubmed.ncbi.nlm.nih.gov/16931002 DMQ13Z8 DI DMQ13Z8 DMQ13Z8 DN 3-Benzyl-2-ethylthio-6-nitro-quinazolin-4(3H)-one DMQ13Z8 MI TT9SL3Q DMQ13Z8 MN Polypeptide deformylase (PDF) DMQ13Z8 MT DTT DMQ13Z8 MA Inhibitor DMQ13Z8 RN Non-classical antifolates. Part 2: synthesis, biological evaluation, and molecular modeling study of some new 2,6-substituted-quinazolin-4-ones. Bioorg Med Chem. 2010 Apr 15;18(8):2849-63. DMQ13Z8 RU https://pubmed.ncbi.nlm.nih.gov/20350811 DM4GWAH DI DM4GWAH DM4GWAH DN 3-benzyl-2-mercapto-6-nitroquinazolin-4(3H)-one DM4GWAH MI TT9SL3Q DM4GWAH MN Polypeptide deformylase (PDF) DM4GWAH MT DTT DM4GWAH MA Inhibitor DM4GWAH RN Non-classical antifolates. Part 2: synthesis, biological evaluation, and molecular modeling study of some new 2,6-substituted-quinazolin-4-ones. Bioorg Med Chem. 2010 Apr 15;18(8):2849-63. DM4GWAH RU https://pubmed.ncbi.nlm.nih.gov/20350811 DMDAO28 DI DMDAO28 DMDAO28 DN 3-Benzyl-3-ethyl-1-phenylazetidine-2,4-dione DMDAO28 MI TTPLTSQ DMDAO28 MN Neutrophil elastase (NE) DMDAO28 MT DTT DMDAO28 MA Inhibitor DMDAO28 RN 4-Oxo-beta-lactams (azetidine-2,4-diones) are potent and selective inhibitors of human leukocyte elastase. J Med Chem. 2010 Jan 14;53(1):241-53. DMDAO28 RU https://pubmed.ncbi.nlm.nih.gov/19904934 DMHINWF DI DMHINWF DMHINWF DN 3-Benzyl-3-methyl-1-phenylazetidine-2,4-dione DMHINWF MI TTPLTSQ DMHINWF MN Neutrophil elastase (NE) DMHINWF MT DTT DMHINWF MA Inhibitor DMHINWF RN 4-Oxo-beta-lactams (azetidine-2,4-diones) are potent and selective inhibitors of human leukocyte elastase. J Med Chem. 2010 Jan 14;53(1):241-53. DMHINWF RU https://pubmed.ncbi.nlm.nih.gov/19904934 DMA5EHC DI DMA5EHC DMA5EHC DN 3-Benzyl-4-hydroxy-2H-benzo[h]chromen-2-one DMA5EHC MI TT8XK6L DMA5EHC MN Quinone reductase 1 (NQO1) DMA5EHC MT DTT DMA5EHC MA Inhibitor DMA5EHC RN Synthesis and biological evaluation of coumarin-based inhibitors of NAD(P)H: quinone oxidoreductase-1 (NQO1). J Med Chem. 2009 Nov 26;52(22):7142-56. DMA5EHC RU https://pubmed.ncbi.nlm.nih.gov/19877692 DM3BFX0 DI DM3BFX0 DM3BFX0 DN 3-Benzyl-4-hydroxy-2H-chromen-2-one DM3BFX0 MI TT8XK6L DM3BFX0 MN Quinone reductase 1 (NQO1) DM3BFX0 MT DTT DM3BFX0 MA Inhibitor DM3BFX0 RN Synthesis and biological evaluation of coumarin-based inhibitors of NAD(P)H: quinone oxidoreductase-1 (NQO1). J Med Chem. 2009 Nov 26;52(22):7142-56. DM3BFX0 RU https://pubmed.ncbi.nlm.nih.gov/19877692 DML0ME9 DI DML0ME9 DML0ME9 DN 3-Benzyl-4-hydroxy-6,7-dimethyl-2H-chromen-2-one DML0ME9 MI TT8XK6L DML0ME9 MN Quinone reductase 1 (NQO1) DML0ME9 MT DTT DML0ME9 MA Inhibitor DML0ME9 RN Synthesis and biological evaluation of coumarin-based inhibitors of NAD(P)H: quinone oxidoreductase-1 (NQO1). J Med Chem. 2009 Nov 26;52(22):7142-56. DML0ME9 RU https://pubmed.ncbi.nlm.nih.gov/19877692 DMZ85NC DI DMZ85NC DMZ85NC DN 3-benzyl-5-fluorobenzo[d]oxazol-2(3H)-one DMZ85NC MI TT6804T DMZ85NC MN MIF messenger RNA (MIF mRNA) DMZ85NC MT DTT DMZ85NC MA Inhibitor DMZ85NC RN Optimization of N-benzyl-benzoxazol-2-ones as receptor antagonists of macrophage migration inhibitory factor (MIF). Bioorg Med Chem Lett. 2010 Oct 1;20(19):5811-4. DMZ85NC RU https://pubmed.ncbi.nlm.nih.gov/20728358 DMKZDYP DI DMKZDYP DMKZDYP DN 3-Benzyl-5-isopropyl-8-methylchromen-2-one DMKZDYP MI TT6OEDT DMKZDYP MN Cannabinoid receptor 1 (CB1) DMKZDYP MT DTT DMKZDYP MA Inhibitor DMKZDYP RN Synthesis and pharmacological evaluation of coumarin derivatives as cannabinoid receptor antagonists and inverse agonists. Bioorg Med Chem. 2009 Apr 1;17(7):2842-51. DMKZDYP RU https://pubmed.ncbi.nlm.nih.gov/19278853 DMKZDYP DI DMKZDYP DMKZDYP DN 3-Benzyl-5-isopropyl-8-methylchromen-2-one DMKZDYP MI TTMSFAW DMKZDYP MN Cannabinoid receptor 2 (CB2) DMKZDYP MT DTT DMKZDYP MA Inhibitor DMKZDYP RN Synthesis and pharmacological evaluation of coumarin derivatives as cannabinoid receptor antagonists and inverse agonists. Bioorg Med Chem. 2009 Apr 1;17(7):2842-51. DMKZDYP RU https://pubmed.ncbi.nlm.nih.gov/19278853 DMF04YH DI DMF04YH DMF04YH DN 3-Benzyl-5-methoxy-7-methylchromen-2-one DMF04YH MI TT6OEDT DMF04YH MN Cannabinoid receptor 1 (CB1) DMF04YH MT DTT DMF04YH MA Inhibitor DMF04YH RN Synthesis and pharmacological evaluation of coumarin derivatives as cannabinoid receptor antagonists and inverse agonists. Bioorg Med Chem. 2009 Apr 1;17(7):2842-51. DMF04YH RU https://pubmed.ncbi.nlm.nih.gov/19278853 DMSIAMN DI DMSIAMN DMSIAMN DN 3-Benzyl-5-methoxychromen-2-one DMSIAMN MI TT6OEDT DMSIAMN MN Cannabinoid receptor 1 (CB1) DMSIAMN MT DTT DMSIAMN MA Inhibitor DMSIAMN RN Synthesis and pharmacological evaluation of coumarin derivatives as cannabinoid receptor antagonists and inverse agonists. Bioorg Med Chem. 2009 Apr 1;17(7):2842-51. DMSIAMN RU https://pubmed.ncbi.nlm.nih.gov/19278853 DMHYQ3Z DI DMHYQ3Z DMHYQ3Z DN 3-benzyl-5-methylbenzo[d]oxazol-2(3H)-one DMHYQ3Z MI TT6804T DMHYQ3Z MN MIF messenger RNA (MIF mRNA) DMHYQ3Z MT DTT DMHYQ3Z MA Inhibitor DMHYQ3Z RN Optimization of N-benzyl-benzoxazol-2-ones as receptor antagonists of macrophage migration inhibitory factor (MIF). Bioorg Med Chem Lett. 2010 Oct 1;20(19):5811-4. DMHYQ3Z RU https://pubmed.ncbi.nlm.nih.gov/20728358 DMGPKIY DI DMGPKIY DMGPKIY DN 3-benzyl-6-methylbenzo[d]oxazol-2(3H)-one DMGPKIY MI TT6804T DMGPKIY MN MIF messenger RNA (MIF mRNA) DMGPKIY MT DTT DMGPKIY MA Inhibitor DMGPKIY RN Optimization of N-benzyl-benzoxazol-2-ones as receptor antagonists of macrophage migration inhibitory factor (MIF). Bioorg Med Chem Lett. 2010 Oct 1;20(19):5811-4. DMGPKIY RU https://pubmed.ncbi.nlm.nih.gov/20728358 DMHQ467 DI DMHQ467 DMHQ467 DN 3-Benzyl-7-methyl-[1,8]naphthyridin-4-ol DMHQ467 MI TTK25J1 DMHQ467 MN Adenosine A1 receptor (ADORA1) DMHQ467 MT DTT DMHQ467 MA Inhibitor DMHQ467 RN 1,8-Naphthyridin-4-one derivatives as new ligands of A2A adenosine receptors. Bioorg Med Chem Lett. 2005 Oct 15;15(20):4604-10. DMHQ467 RU https://pubmed.ncbi.nlm.nih.gov/16099648 DMHQ467 DI DMHQ467 DMHQ467 DN 3-Benzyl-7-methyl-[1,8]naphthyridin-4-ol DMHQ467 MI TTM2AOE DMHQ467 MN Adenosine A2a receptor (ADORA2A) DMHQ467 MT DTT DMHQ467 MA Inhibitor DMHQ467 RN 1,8-Naphthyridin-4-one derivatives as new ligands of A2A adenosine receptors. Bioorg Med Chem Lett. 2005 Oct 15;15(20):4604-10. DMHQ467 RU https://pubmed.ncbi.nlm.nih.gov/16099648 DM12RH3 DI DM12RH3 DM12RH3 DN 3-Benzyl-7-methyl-[1,8]naphthyridine-4-thiol DM12RH3 MI TTK25J1 DM12RH3 MN Adenosine A1 receptor (ADORA1) DM12RH3 MT DTT DM12RH3 MA Inhibitor DM12RH3 RN 1,8-Naphthyridin-4-one derivatives as new ligands of A2A adenosine receptors. Bioorg Med Chem Lett. 2005 Oct 15;15(20):4604-10. DM12RH3 RU https://pubmed.ncbi.nlm.nih.gov/16099648 DM12RH3 DI DM12RH3 DM12RH3 DN 3-Benzyl-7-methyl-[1,8]naphthyridine-4-thiol DM12RH3 MI TTM2AOE DM12RH3 MN Adenosine A2a receptor (ADORA2A) DM12RH3 MT DTT DM12RH3 MA Inhibitor DM12RH3 RN 1,8-Naphthyridin-4-one derivatives as new ligands of A2A adenosine receptors. Bioorg Med Chem Lett. 2005 Oct 15;15(20):4604-10. DM12RH3 RU https://pubmed.ncbi.nlm.nih.gov/16099648 DMB4WP5 DI DMB4WP5 DMB4WP5 DN 3-Benzylamino-5-ethyl-6-methyl-1H-pyridin-2-one DMB4WP5 MI TT84ETX DMB4WP5 MN Human immunodeficiency virus Reverse transcriptase (HIV RT) DMB4WP5 MT DTT DMB4WP5 MA Inhibitor DMB4WP5 RN Synthesis and evaluation of 2-pyridinone derivatives as HIV-1-specific reverse transcriptase inhibitors. 2. Analogues of 3-aminopyridin-2(1H)-one. J Med Chem. 1992 Oct 16;35(21):3792-802. DMB4WP5 RU https://pubmed.ncbi.nlm.nih.gov/1279173 DMZIOJS DI DMZIOJS DMZIOJS DN 3-benzyl-N-(2-morpholinoethyl)quinoxalin-2-amine DMZIOJS MI TT3WG5C DMZIOJS MN Monoamine oxidase type A (MAO-A) DMZIOJS MT DTT DMZIOJS MA Inhibitor DMZIOJS RN Synthesis of 3-benzyl-2-substituted quinoxalines as novel monoamine oxidase A inhibitors. Bioorg Med Chem Lett. 2006 Mar 15;16(6):1753-6. DMZIOJS RU https://pubmed.ncbi.nlm.nih.gov/16356714 DM94K83 DI DM94K83 DM94K83 DN 3-Benzyloxy-2-phenyl-piperidine DM94K83 MI TTZPO1L DM94K83 MN Substance-P receptor (TACR1) DM94K83 MT DTT DM94K83 MA Inhibitor DM94K83 RN 3-Benzyloxy-2-phenylpiperidine NK1 antagonists: the influence of alpha methyl substitution, Bioorg. Med. Chem. Lett. 7(23):2959-2962 (1997). DM94K83 RU http://www.sciencedirect.com/science/article/pii/S0960894X97101184 DMKD874 DI DMKD874 DMKD874 DN 3-benzyloxy-4-methoxy-2'-hydroxychalcone DMKD874 MI TTVKILB DMKD874 MN Prostaglandin G/H synthase 2 (COX-2) DMKD874 MT DTT DMKD874 MA Inhibitor DMKD874 RN Inhibitory activity of prostaglandin E2 production by the synthetic 2'-hydroxychalcone analogues: Synthesis and SAR study. Bioorg Med Chem Lett. 2009 Mar 15;19(6):1650-3. DMKD874 RU https://pubmed.ncbi.nlm.nih.gov/19233646 DMPG315 DI DMPG315 DMPG315 DN 3-Benzyloxy-6,7-dimethoxy-quinoline DMPG315 MI TT8FYO9 DMPG315 MN Platelet-derived growth factor receptor alpha (PDGFRA) DMPG315 MT DTT DMPG315 MA Inhibitor DMPG315 RN A new series of PDGF receptor tyrosine kinase inhibitors: 3-substituted quinoline derivatives. J Med Chem. 1994 Jul 8;37(14):2129-37. DMPG315 RU https://pubmed.ncbi.nlm.nih.gov/8035419 DMPG315 DI DMPG315 DMPG315 DN 3-Benzyloxy-6,7-dimethoxy-quinoline DMPG315 MI TTI7421 DMPG315 MN Platelet-derived growth factor receptor beta (PDGFRB) DMPG315 MT DTT DMPG315 MA Inhibitor DMPG315 RN A new series of PDGF receptor tyrosine kinase inhibitors: 3-substituted quinoline derivatives. J Med Chem. 1994 Jul 8;37(14):2129-37. DMPG315 RU https://pubmed.ncbi.nlm.nih.gov/8035419 DMLEXWC DI DMLEXWC DMLEXWC DN 3beta,6beta-dihydroxyolean-12-en-27-oic acid DMLEXWC MI TTELIN2 DMLEXWC MN PTPN1 messenger RNA (PTPN1 mRNA) DMLEXWC MT DTT DMLEXWC MA Inhibitor DMLEXWC RN Protein tyrosine phosphatase 1B inhibitory activity of triterpenes isolated from Astilbe koreana. Bioorg Med Chem Lett. 2006 Jun 15;16(12):3273-6. DMLEXWC RU https://pubmed.ncbi.nlm.nih.gov/16580200 DMOZAHB DI DMOZAHB DMOZAHB DN 3beta-acetoxyolean-12-en-27-oic acid DMOZAHB MI TTELIN2 DMOZAHB MN PTPN1 messenger RNA (PTPN1 mRNA) DMOZAHB MT DTT DMOZAHB MA Inhibitor DMOZAHB RN Protein tyrosine phosphatase 1B inhibitory activity of triterpenes isolated from Astilbe koreana. Bioorg Med Chem Lett. 2006 Jun 15;16(12):3273-6. DMOZAHB RU https://pubmed.ncbi.nlm.nih.gov/16580200 DMF6VGK DI DMF6VGK DMF6VGK DN 3beta-hydroxyolean-12-en-27-oic acid DMF6VGK MI TTELIN2 DMF6VGK MN PTPN1 messenger RNA (PTPN1 mRNA) DMF6VGK MT DTT DMF6VGK MA Inhibitor DMF6VGK RN Protein tyrosine phosphatase 1B inhibitory activity of triterpenes isolated from Astilbe koreana. Bioorg Med Chem Lett. 2006 Jun 15;16(12):3273-6. DMF6VGK RU https://pubmed.ncbi.nlm.nih.gov/16580200 DML8NY0 DI DML8NY0 DML8NY0 DN 3beta-hydroxyrus-12,19(29)-dien-28-oic acid DML8NY0 MI TTIU7X1 DML8NY0 MN Herpes simplex virus DNA polymerase UL30 (HSV UL30) DML8NY0 MT DTT DML8NY0 MA Inhibitor DML8NY0 RN DNA polymerase beta inhibitors from Baeckea gunniana. J Nat Prod. 1999 Dec;62(12):1624-6. DML8NY0 RU https://pubmed.ncbi.nlm.nih.gov/10654412 DMKL59W DI DMKL59W DMKL59W DN 3beta-hydroxyrus-18,20(30)-dien-28-oic acid DMKL59W MI TTIU7X1 DMKL59W MN Herpes simplex virus DNA polymerase UL30 (HSV UL30) DMKL59W MT DTT DMKL59W MA Inhibitor DMKL59W RN DNA polymerase beta inhibitors from Baeckea gunniana. J Nat Prod. 1999 Dec;62(12):1624-6. DMKL59W RU https://pubmed.ncbi.nlm.nih.gov/10654412 DM6NFO0 DI DM6NFO0 DM6NFO0 DN 3beta-hydroxyurs-12-en-27-oic acid DM6NFO0 MI TTELIN2 DM6NFO0 MN PTPN1 messenger RNA (PTPN1 mRNA) DM6NFO0 MT DTT DM6NFO0 MA Inhibitor DM6NFO0 RN Protein tyrosine phosphatase 1B inhibitory activity of triterpenes isolated from Astilbe koreana. Bioorg Med Chem Lett. 2006 Jun 15;16(12):3273-6. DM6NFO0 RU https://pubmed.ncbi.nlm.nih.gov/16580200 DMZ8WMA DI DMZ8WMA DMZ8WMA DN 3-bicyclo[2.2.1]hept-2-yl-benzene-1,2-diol DMZ8WMA MI TT5OEKU DMZ8WMA MN Voltage-gated potassium channel Kv2.1 (KCNB1) DMZ8WMA MT DTT DMZ8WMA MA Blocker (channel blocker) DMZ8WMA RN Novel neuroprotective K+ channel inhibitor identified by high-throughput screening in yeast. Mol Pharmacol. 2004 Jan;65(1):214-9. DMZ8WMA RU https://pubmed.ncbi.nlm.nih.gov/14722253 DMHSAOQ DI DMHSAOQ DMHSAOQ DN 3-Biphenyl-3-yl-N-hydroxy-N-methyl-acrylamide DMHSAOQ MI TT2J34L DMHSAOQ MN Arachidonate 5-lipoxygenase (5-LOX) DMHSAOQ MT DTT DMHSAOQ MA Inhibitor DMHSAOQ RN Hydroxamic acid inhibitors of 5-lipoxygenase: quantitative structure-activity relationships. J Med Chem. 1990 Mar;33(3):992-8. DMHSAOQ RU https://pubmed.ncbi.nlm.nih.gov/2308149 DMMC2Q9 DI DMMC2Q9 DMMC2Q9 DN 3-biphenyl-4-ylethynyl-5-methyl-[1,2,4]triazine DMMC2Q9 MI TTHS256 DMMC2Q9 MN Metabotropic glutamate receptor 5 (mGluR5) DMMC2Q9 MT DTT DMMC2Q9 MA Inhibitor DMMC2Q9 RN Synthesis and pharmacological evaluation of phenylethynyl[1,2,4]methyltriazines as analogues of 3-methyl-6-(phenylethynyl)pyridine. J Med Chem. 2007 Jul 12;50(14):3388-91. DMMC2Q9 RU https://pubmed.ncbi.nlm.nih.gov/17569516 DMKBRIM DI DMKBRIM DMKBRIM DN 3-Biphenyl-4-yl-N-hydroxy-N-methyl-acrylamide DMKBRIM MI TT2J34L DMKBRIM MN Arachidonate 5-lipoxygenase (5-LOX) DMKBRIM MT DTT DMKBRIM MA Inhibitor DMKBRIM RN Hydroxamic acid inhibitors of 5-lipoxygenase: quantitative structure-activity relationships. J Med Chem. 1990 Mar;33(3):992-8. DMKBRIM RU https://pubmed.ncbi.nlm.nih.gov/2308149 DMRCJW0 DI DMRCJW0 DMRCJW0 DN 3-boronobenzoic acid DMRCJW0 MI TTLP6GN DMRCJW0 MN Bacterial DD-carboxypeptidase (Bact vanYB) DMRCJW0 MT DTT DMRCJW0 MA Inhibitor DMRCJW0 RN Synthesis and evaluation of 3-(dihydroxyboryl)benzoic acids as D,D-carboxypeptidase R39 inhibitors. J Med Chem. 2009 Oct 8;52(19):6097-106. DMRCJW0 RU https://pubmed.ncbi.nlm.nih.gov/19731939 DM03ROH DI DM03ROH DM03ROH DN 3-bromo-1-(4-hexylphenyl)propan-1-one DM03ROH MI TTTSEPU DM03ROH MN Thyroid hormone receptor alpha (THRA) DM03ROH MT DTT DM03ROH MA Inhibitor DM03ROH RN Inhibitors of the interaction of a thyroid hormone receptor and coactivators: preliminary structure-activity relationships. J Med Chem. 2007 Nov 1;50(22):5269-80. DM03ROH RU https://pubmed.ncbi.nlm.nih.gov/17918822 DM03ROH DI DM03ROH DM03ROH DN 3-bromo-1-(4-hexylphenyl)propan-1-one DM03ROH MI TTGER3L DM03ROH MN Thyroid hormone receptor beta (THRB) DM03ROH MT DTT DM03ROH MA Inhibitor DM03ROH RN Inhibitors of the interaction of a thyroid hormone receptor and coactivators: preliminary structure-activity relationships. J Med Chem. 2007 Nov 1;50(22):5269-80. DM03ROH RU https://pubmed.ncbi.nlm.nih.gov/17918822 DMZGWL2 DI DMZGWL2 DMZGWL2 DN 3-Bromo-1H-indazole-7-carbonitrile DMZGWL2 MI TTZUFI5 DMZGWL2 MN Nitric-oxide synthase brain (NOS1) DMZGWL2 MT DTT DMZGWL2 MA Inhibitor DMZGWL2 RN Inhibitory effects of a series of 7-substituted-indazoles toward nitric oxide synthases: particular potency of 1H-indazole-7-carbonitrile. Bioorg Med Chem. 2008 Jun 1;16(11):5962-73. DMZGWL2 RU https://pubmed.ncbi.nlm.nih.gov/18502134 DMZGWL2 DI DMZGWL2 DMZGWL2 DN 3-Bromo-1H-indazole-7-carbonitrile DMZGWL2 MI TTCM4B3 DMZGWL2 MN Nitric-oxide synthase endothelial (NOS3) DMZGWL2 MT DTT DMZGWL2 MA Inhibitor DMZGWL2 RN Inhibitory effects of a series of 7-substituted-indazoles toward nitric oxide synthases: particular potency of 1H-indazole-7-carbonitrile. Bioorg Med Chem. 2008 Jun 1;16(11):5962-73. DMZGWL2 RU https://pubmed.ncbi.nlm.nih.gov/18502134 DMZGWL2 DI DMZGWL2 DMZGWL2 DN 3-Bromo-1H-indazole-7-carbonitrile DMZGWL2 MI TTF10I9 DMZGWL2 MN Nitric-oxide synthase inducible (NOS2) DMZGWL2 MT DTT DMZGWL2 MA Inhibitor DMZGWL2 RN Inhibitory effects of a series of 7-substituted-indazoles toward nitric oxide synthases: particular potency of 1H-indazole-7-carbonitrile. Bioorg Med Chem. 2008 Jun 1;16(11):5962-73. DMZGWL2 RU https://pubmed.ncbi.nlm.nih.gov/18502134 DM1BALV DI DM1BALV DM1BALV DN 3-Bromo-2'-hydroxy-4-methoxychalcone DM1BALV MI TTVKILB DM1BALV MN Prostaglandin G/H synthase 2 (COX-2) DM1BALV MT DTT DM1BALV MA Inhibitor DM1BALV RN Inhibitory activity of prostaglandin E2 production by the synthetic 2'-hydroxychalcone analogues: Synthesis and SAR study. Bioorg Med Chem Lett. 2009 Mar 15;19(6):1650-3. DM1BALV RU https://pubmed.ncbi.nlm.nih.gov/19233646 DMPZ4M8 DI DMPZ4M8 DMPZ4M8 DN 3-bromo-4,4',5-trimethoxy-(Z)-stilbene DMPZ4M8 MI TTYFKSZ DMPZ4M8 MN Tubulin beta (TUBB) DMPZ4M8 MT DTT DMPZ4M8 MA Inhibitor DMPZ4M8 RN 2-amino and 2'-aminocombretastatin derivatives as potent antimitotic agents. J Med Chem. 2006 Oct 19;49(21):6412-5. DMPZ4M8 RU https://pubmed.ncbi.nlm.nih.gov/17034147 DMPZ4M8 DI DMPZ4M8 DMPZ4M8 DN 3-bromo-4,4',5-trimethoxy-(Z)-stilbene DMPZ4M8 MI TTJ2PTI DMPZ4M8 MN Tubulin beta-2 chain (TUBB2) DMPZ4M8 MT DTT DMPZ4M8 MA Inhibitor DMPZ4M8 RN 2-amino and 2'-aminocombretastatin derivatives as potent antimitotic agents. J Med Chem. 2006 Oct 19;49(21):6412-5. DMPZ4M8 RU https://pubmed.ncbi.nlm.nih.gov/17034147 DMPQOS2 DI DMPQOS2 DMPQOS2 DN 3-bromo-5-(2-methylquinolin-7-yl)benzonitrile DMPQOS2 MI TTHS256 DMPQOS2 MN Metabotropic glutamate receptor 5 (mGluR5) DMPQOS2 MT DTT DMPQOS2 MA Inhibitor DMPQOS2 RN Rational design of 7-arylquinolines as non-competitive metabotropic glutamate receptor subtype 5 antagonists. Bioorg Med Chem Lett. 2007 Aug 15;17(16):4415-8. DMPQOS2 RU https://pubmed.ncbi.nlm.nih.gov/17590335 DMOXY78 DI DMOXY78 DMOXY78 DN 3-bromo-5-[(2-methyl-4-thiazolyl)ethynyl]pyridine DMOXY78 MI TTHS256 DMOXY78 MN Metabotropic glutamate receptor 5 (mGluR5) DMOXY78 MT DTT DMOXY78 MA Inhibitor DMOXY78 RN Synthesis and structure-activity relationships of 3-[(2-methyl-1,3-thiazol-4-yl)ethynyl]pyridine analogues as potent, noncompetitive metabotropic g... J Med Chem. 2006 Feb 9;49(3):1080-100. DMOXY78 RU https://pubmed.ncbi.nlm.nih.gov/16451073 DMZTDCL DI DMZTDCL DMZTDCL DN 3-Bromo-5-phenylsalicylc acid DMZTDCL MI TT5ZWB6 DMZTDCL MN Dihydrodiol dehydrogenase type I (AKR1C3) DMZTDCL MT DTT DMZTDCL MA Inhibitor DMZTDCL RN Structure-guided design, synthesis, and evaluation of salicylic acid-based inhibitors targeting a selectivity pocket in the active site of human 20... J Med Chem. 2009 May 28;52(10):3259-64. DMZTDCL RU https://pubmed.ncbi.nlm.nih.gov/19397269 DMXZB5C DI DMXZB5C DMXZB5C DN 3-Bromo-6-nitro-2-piperazin-1-yl-quinoline DMXZB5C MI TT3ROYC DMXZB5C MN Serotonin transporter (SERT) DMXZB5C MT DTT DMXZB5C MA Inhibitor DMXZB5C RN Syntheses and binding affinities of 6-nitroquipazine analogues for serotonin transporter. Part 1. Bioorg Med Chem Lett. 2000 Jul 17;10(14):1559-62. DMXZB5C RU https://pubmed.ncbi.nlm.nih.gov/10915050 DMM7DHB DI DMM7DHB DMM7DHB DN 3-bromo-7-nitro-1H-indazole DMM7DHB MI TTZUFI5 DMM7DHB MN Nitric-oxide synthase brain (NOS1) DMM7DHB MT DTT DMM7DHB MA Inhibitor DMM7DHB RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMM7DHB RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMM7DHB DI DMM7DHB DMM7DHB DN 3-bromo-7-nitro-1H-indazole DMM7DHB MI TTCM4B3 DMM7DHB MN Nitric-oxide synthase endothelial (NOS3) DMM7DHB MT DTT DMM7DHB MA Inhibitor DMM7DHB RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMM7DHB RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMM7DHB DI DMM7DHB DMM7DHB DN 3-bromo-7-nitro-1H-indazole DMM7DHB MI TTF10I9 DMM7DHB MN Nitric-oxide synthase inducible (NOS2) DMM7DHB MT DTT DMM7DHB MA Inhibitor DMM7DHB RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMM7DHB RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMPF7O2 DI DMPF7O2 DMPF7O2 DN 3-bromoboldine DMPF7O2 MI TTZFYLI DMPF7O2 MN Dopamine D1 receptor (D1R) DMPF7O2 MT DTT DMPF7O2 MA Inhibitor DMPF7O2 RN Halogenated boldine derivatives with enhanced monoamine receptor selectivity. J Nat Prod. 2000 Apr;63(4):480-4. DMPF7O2 RU https://pubmed.ncbi.nlm.nih.gov/10785418 DMPF7O2 DI DMPF7O2 DMPF7O2 DN 3-bromoboldine DMPF7O2 MI TTEX248 DMPF7O2 MN Dopamine D2 receptor (D2R) DMPF7O2 MT DTT DMPF7O2 MA Inhibitor DMPF7O2 RN Halogenated boldine derivatives with enhanced monoamine receptor selectivity. J Nat Prod. 2000 Apr;63(4):480-4. DMPF7O2 RU https://pubmed.ncbi.nlm.nih.gov/10785418 DMPF7O2 DI DMPF7O2 DMPF7O2 DN 3-bromoboldine DMPF7O2 MI TTLA931 DMPF7O2 MN Neuronal acetylcholine receptor alpha-7 (CHRNA7) DMPF7O2 MT DTT DMPF7O2 MA Inhibitor DMPF7O2 RN Aporphine metho salts as neuronal nicotinic acetylcholine receptor blockers. Bioorg Med Chem. 2007 May 15;15(10):3368-72. DMPF7O2 RU https://pubmed.ncbi.nlm.nih.gov/17391965 DM62Y1S DI DM62Y1S DM62Y1S DN 3-bromo-N-(6-methylpyridin-2-yl)benzamide DM62Y1S MI TTHS256 DM62Y1S MN Metabotropic glutamate receptor 5 (mGluR5) DM62Y1S MT DTT DM62Y1S MA Inhibitor DM62Y1S RN Design and synthesis of noncompetitive metabotropic glutamate receptor subtype 5 antagonists. Bioorg Med Chem Lett. 2006 Jul 1;16(13):3371-5. DM62Y1S RU https://pubmed.ncbi.nlm.nih.gov/16678408 DMXZW3R DI DMXZW3R DMXZW3R DN 3-bromophenyl-difluoromethanesulfonamide DMXZW3R MI TTUNARX DMXZW3R MN Carbonic anhydrase (CA) DMXZW3R MT DTT DMXZW3R MA Inhibitor DMXZW3R RN Carbonic anhydrase inhibitors: inhibition of the human isozymes I, II, VA, and IX with a library of substituted difluoromethanesulfonamides. Bioorg Med Chem Lett. 2005 Dec 1;15(23):5192-6. DMXZW3R RU https://pubmed.ncbi.nlm.nih.gov/16203142 DMXZW3R DI DMXZW3R DMXZW3R DN 3-bromophenyl-difluoromethanesulfonamide DMXZW3R MI TTHQPL7 DMXZW3R MN Carbonic anhydrase I (CA-I) DMXZW3R MT DTT DMXZW3R MA Inhibitor DMXZW3R RN Carbonic anhydrase inhibitors: inhibition of the human isozymes I, II, VA, and IX with a library of substituted difluoromethanesulfonamides. Bioorg Med Chem Lett. 2005 Dec 1;15(23):5192-6. DMXZW3R RU https://pubmed.ncbi.nlm.nih.gov/16203142 DMXZW3R DI DMXZW3R DMXZW3R DN 3-bromophenyl-difluoromethanesulfonamide DMXZW3R MI TTANPDJ DMXZW3R MN Carbonic anhydrase II (CA-II) DMXZW3R MT DTT DMXZW3R MA Inhibitor DMXZW3R RN Carbonic anhydrase inhibitors: inhibition of the human isozymes I, II, VA, and IX with a library of substituted difluoromethanesulfonamides. Bioorg Med Chem Lett. 2005 Dec 1;15(23):5192-6. DMXZW3R RU https://pubmed.ncbi.nlm.nih.gov/16203142 DMXZW3R DI DMXZW3R DMXZW3R DN 3-bromophenyl-difluoromethanesulfonamide DMXZW3R MI TT2LVK8 DMXZW3R MN Carbonic anhydrase IX (CA-IX) DMXZW3R MT DTT DMXZW3R MA Inhibitor DMXZW3R RN Carbonic anhydrase inhibitors: inhibition of the human isozymes I, II, VA, and IX with a library of substituted difluoromethanesulfonamides. Bioorg Med Chem Lett. 2005 Dec 1;15(23):5192-6. DMXZW3R RU https://pubmed.ncbi.nlm.nih.gov/16203142 DMK7D8N DI DMK7D8N DMK7D8N DN 3'-bromopropiophenonethiosemicarbazone DMK7D8N MI TTEAID7 DMK7D8N MN Trypanosoma Cruzipain (Trypano CYSP) DMK7D8N MT DTT DMK7D8N MA Inhibitor DMK7D8N RN Studies toward the structural optimization of novel thiazolylhydrazone-based potent antitrypanosomal agents. Bioorg Med Chem. 2010 Nov 15;18(22):7826-35. DMK7D8N RU https://pubmed.ncbi.nlm.nih.gov/20961766 DMYL3ST DI DMYL3ST DMYL3ST DN 3-bromopyruvate DMYL3ST MI TT58ZYW DMYL3ST MN Mycobacterium Isocitrate lyase (MycB icl) DMYL3ST MT DTT DMYL3ST MA Inhibitor DMYL3ST RN Structure of isocitrate lyase, a persistence factor of Mycobacterium tuberculosis. Nat Struct Biol. 2000 Aug;7(8):663-8. DMYL3ST RU https://pubmed.ncbi.nlm.nih.gov/10932251 DMQ8H74 DI DMQ8H74 DMQ8H74 DN 3-Butoxy-9H-beta-carboline DMQ8H74 MI TT1MPAY DMQ8H74 MN GABA(A) receptor alpha-1 (GABRA1) DMQ8H74 MT DTT DMQ8H74 MA Inhibitor DMQ8H74 RN Predictive binding of beta-carboline inverse agonists and antagonists via the CoMFA/GOLPE approach. J Med Chem. 1992 Oct 30;35(22):4001-10. DMQ8H74 RU https://pubmed.ncbi.nlm.nih.gov/1331452 DMQ8H74 DI DMQ8H74 DMQ8H74 DN 3-Butoxy-9H-beta-carboline DMQ8H74 MI TTBMV1G DMQ8H74 MN GABA(A) receptor alpha-2 (GABRA2) DMQ8H74 MT DTT DMQ8H74 MA Inhibitor DMQ8H74 RN Design, synthesis, and subtype selectivity of 3,6-disubstituted -carbolines at Bz/GABA(A)ergic receptors. SAR and studies directed toward agents f... Bioorg Med Chem. 2010 Nov 1;18(21):7548-64. DMQ8H74 RU https://pubmed.ncbi.nlm.nih.gov/20888240 DMQ8H74 DI DMQ8H74 DMQ8H74 DN 3-Butoxy-9H-beta-carboline DMQ8H74 MI TT37EDJ DMQ8H74 MN GABA(A) receptor alpha-3 (GABRA3) DMQ8H74 MT DTT DMQ8H74 MA Inhibitor DMQ8H74 RN Design, synthesis, and subtype selectivity of 3,6-disubstituted -carbolines at Bz/GABA(A)ergic receptors. SAR and studies directed toward agents f... Bioorg Med Chem. 2010 Nov 1;18(21):7548-64. DMQ8H74 RU https://pubmed.ncbi.nlm.nih.gov/20888240 DMQ8H74 DI DMQ8H74 DMQ8H74 DN 3-Butoxy-9H-beta-carboline DMQ8H74 MI TTNZPQ1 DMQ8H74 MN GABA(A) receptor alpha-5 (GABRA5) DMQ8H74 MT DTT DMQ8H74 MA Inhibitor DMQ8H74 RN Design, synthesis, and subtype selectivity of 3,6-disubstituted -carbolines at Bz/GABA(A)ergic receptors. SAR and studies directed toward agents f... Bioorg Med Chem. 2010 Nov 1;18(21):7548-64. DMQ8H74 RU https://pubmed.ncbi.nlm.nih.gov/20888240 DMQ8H74 DI DMQ8H74 DMQ8H74 DN 3-Butoxy-9H-beta-carboline DMQ8H74 MI TT06RH5 DMQ8H74 MN GABA(A) receptor gamma-2 (GABRG2) DMQ8H74 MT DTT DMQ8H74 MA Inhibitor DMQ8H74 RN Design, synthesis, and subtype selectivity of 3,6-disubstituted -carbolines at Bz/GABA(A)ergic receptors. SAR and studies directed toward agents f... Bioorg Med Chem. 2010 Nov 1;18(21):7548-64. DMQ8H74 RU https://pubmed.ncbi.nlm.nih.gov/20888240 DMQ8H74 DI DMQ8H74 DMQ8H74 DN 3-Butoxy-9H-beta-carboline DMQ8H74 MI TTNJYV2 DMQ8H74 MN Gamma-aminobutyric acid receptor (GAR) DMQ8H74 MT DTT DMQ8H74 MA Inhibitor DMQ8H74 RN Predictive binding of beta-carboline inverse agonists and antagonists via the CoMFA/GOLPE approach. J Med Chem. 1992 Oct 30;35(22):4001-10. DMQ8H74 RU https://pubmed.ncbi.nlm.nih.gov/1331452 DMRF2Q8 DI DMRF2Q8 DMRF2Q8 DN 3-butoxycarbonyl-4-quinolone DMRF2Q8 MI TT1MPAY DMRF2Q8 MN GABA(A) receptor alpha-1 (GABRA1) DMRF2Q8 MT DTT DMRF2Q8 MA Inhibitor DMRF2Q8 RN 4-quinolone derivatives: high-affinity ligands at the benzodiazepine site of brain GABA A receptors. synthesis, pharmacology, and pharmacophore mod... J Med Chem. 2006 Apr 20;49(8):2526-33. DMRF2Q8 RU https://pubmed.ncbi.nlm.nih.gov/16610795 DMRF2Q8 DI DMRF2Q8 DMRF2Q8 DN 3-butoxycarbonyl-4-quinolone DMRF2Q8 MI TTZA1NY DMRF2Q8 MN GABA(A) receptor beta-2 (GABRB2) DMRF2Q8 MT DTT DMRF2Q8 MA Inhibitor DMRF2Q8 RN 4-quinolone derivatives: high-affinity ligands at the benzodiazepine site of brain GABA A receptors. synthesis, pharmacology, and pharmacophore mod... J Med Chem. 2006 Apr 20;49(8):2526-33. DMRF2Q8 RU https://pubmed.ncbi.nlm.nih.gov/16610795 DMRF2Q8 DI DMRF2Q8 DMRF2Q8 DN 3-butoxycarbonyl-4-quinolone DMRF2Q8 MI TT06RH5 DMRF2Q8 MN GABA(A) receptor gamma-2 (GABRG2) DMRF2Q8 MT DTT DMRF2Q8 MA Inhibitor DMRF2Q8 RN 4-quinolone derivatives: high-affinity ligands at the benzodiazepine site of brain GABA A receptors. synthesis, pharmacology, and pharmacophore mod... J Med Chem. 2006 Apr 20;49(8):2526-33. DMRF2Q8 RU https://pubmed.ncbi.nlm.nih.gov/16610795 DMRF2Q8 DI DMRF2Q8 DMRF2Q8 DN 3-butoxycarbonyl-4-quinolone DMRF2Q8 MI TTNJYV2 DMRF2Q8 MN Gamma-aminobutyric acid receptor (GAR) DMRF2Q8 MT DTT DMRF2Q8 MA Inhibitor DMRF2Q8 RN 4-quinolone derivatives: high-affinity ligands at the benzodiazepine site of brain GABA A receptors. synthesis, pharmacology, and pharmacophore mod... J Med Chem. 2006 Apr 20;49(8):2526-33. DMRF2Q8 RU https://pubmed.ncbi.nlm.nih.gov/16610795 DMD6PMZ DI DMD6PMZ DMD6PMZ DN 3-butoxycarbonyl-6-ethyl-4-quinolone DMD6PMZ MI TT1MPAY DMD6PMZ MN GABA(A) receptor alpha-1 (GABRA1) DMD6PMZ MT DTT DMD6PMZ MA Inhibitor DMD6PMZ RN 4-quinolone derivatives: high-affinity ligands at the benzodiazepine site of brain GABA A receptors. synthesis, pharmacology, and pharmacophore mod... J Med Chem. 2006 Apr 20;49(8):2526-33. DMD6PMZ RU https://pubmed.ncbi.nlm.nih.gov/16610795 DMD6PMZ DI DMD6PMZ DMD6PMZ DN 3-butoxycarbonyl-6-ethyl-4-quinolone DMD6PMZ MI TTZA1NY DMD6PMZ MN GABA(A) receptor beta-2 (GABRB2) DMD6PMZ MT DTT DMD6PMZ MA Inhibitor DMD6PMZ RN 4-quinolone derivatives: high-affinity ligands at the benzodiazepine site of brain GABA A receptors. synthesis, pharmacology, and pharmacophore mod... J Med Chem. 2006 Apr 20;49(8):2526-33. DMD6PMZ RU https://pubmed.ncbi.nlm.nih.gov/16610795 DMD6PMZ DI DMD6PMZ DMD6PMZ DN 3-butoxycarbonyl-6-ethyl-4-quinolone DMD6PMZ MI TT06RH5 DMD6PMZ MN GABA(A) receptor gamma-2 (GABRG2) DMD6PMZ MT DTT DMD6PMZ MA Inhibitor DMD6PMZ RN 4-quinolone derivatives: high-affinity ligands at the benzodiazepine site of brain GABA A receptors. synthesis, pharmacology, and pharmacophore mod... J Med Chem. 2006 Apr 20;49(8):2526-33. DMD6PMZ RU https://pubmed.ncbi.nlm.nih.gov/16610795 DMD6PMZ DI DMD6PMZ DMD6PMZ DN 3-butoxycarbonyl-6-ethyl-4-quinolone DMD6PMZ MI TTNJYV2 DMD6PMZ MN Gamma-aminobutyric acid receptor (GAR) DMD6PMZ MT DTT DMD6PMZ MA Inhibitor DMD6PMZ RN 4-quinolone derivatives: high-affinity ligands at the benzodiazepine site of brain GABA A receptors. synthesis, pharmacology, and pharmacophore mod... J Med Chem. 2006 Apr 20;49(8):2526-33. DMD6PMZ RU https://pubmed.ncbi.nlm.nih.gov/16610795 DMRI503 DI DMRI503 DMRI503 DN 3-Butyl-[1,4]oxazepan-(5Z)-ylideneamine DMRI503 MI TTF10I9 DMRI503 MN Nitric-oxide synthase inducible (NOS2) DMRI503 MT DTT DMRI503 MA Inhibitor DMRI503 RN Selective heterocyclic amidine inhibitors of human inducible nitric oxide synthase. Bioorg Med Chem Lett. 2001 Oct 8;11(19):2651-3. DMRI503 RU https://pubmed.ncbi.nlm.nih.gov/11551770 DM6A80U DI DM6A80U DM6A80U DN 3-Butyl-[1,4]thiazepan-(5E)-ylideneamine DM6A80U MI TTZUFI5 DM6A80U MN Nitric-oxide synthase brain (NOS1) DM6A80U MT DTT DM6A80U MA Inhibitor DM6A80U RN Synthesis of analogs of (1,4)-3- and 5-imino oxazepane, thiazepane, and diazepane as inhibitors of nitric oxide synthases. Bioorg Med Chem Lett. 2004 Dec 6;14(23):5907-11. DM6A80U RU https://pubmed.ncbi.nlm.nih.gov/15501067 DM6A80U DI DM6A80U DM6A80U DN 3-Butyl-[1,4]thiazepan-(5E)-ylideneamine DM6A80U MI TTF10I9 DM6A80U MN Nitric-oxide synthase inducible (NOS2) DM6A80U MT DTT DM6A80U MA Inhibitor DM6A80U RN Synthesis of analogs of (1,4)-3- and 5-imino oxazepane, thiazepane, and diazepane as inhibitors of nitric oxide synthases. Bioorg Med Chem Lett. 2004 Dec 6;14(23):5907-11. DM6A80U RU https://pubmed.ncbi.nlm.nih.gov/15501067 DMXF8M0 DI DMXF8M0 DMXF8M0 DN 3-butyl-1-(naphthalen-1-yl)piperidin-4-amine DMXF8M0 MI TTDIGC1 DMXF8M0 MN Dipeptidyl peptidase 4 (DPP-4) DMXF8M0 MT DTT DMXF8M0 MA Inhibitor DMXF8M0 RN 1,3-disubstituted 4-aminopiperidines as useful tools in the optimization of the 2-aminobenzo[a]quinolizine dipeptidyl peptidase IV inhibitors. Bioorg Med Chem Lett. 2007 Jun 1;17(11):2966-70. DMXF8M0 RU https://pubmed.ncbi.nlm.nih.gov/17418568 DMDOPVM DI DMDOPVM DMDOPVM DN 3-Butyl-2,3,4,5-tetrahydro-1H-benzo[d]azepin-6-ol DMDOPVM MI TTSQIFT DMDOPVM MN 5-HT 1A receptor (HTR1A) DMDOPVM MT DTT DMDOPVM MA Inhibitor DMDOPVM RN 6-Hydroxy-3-n-propyl-2,3,4,5-tetrahydro-1H-3-benzazepine and analogs: new centrally acting 5-HT1A receptor agonists. J Med Chem. 1992 Oct 30;35(22):3984-90. DMDOPVM RU https://pubmed.ncbi.nlm.nih.gov/1433207 DMDOPVM DI DMDOPVM DMDOPVM DN 3-Butyl-2,3,4,5-tetrahydro-1H-benzo[d]azepin-6-ol DMDOPVM MI TTEX248 DMDOPVM MN Dopamine D2 receptor (D2R) DMDOPVM MT DTT DMDOPVM MA Inhibitor DMDOPVM RN 6-Hydroxy-3-n-propyl-2,3,4,5-tetrahydro-1H-3-benzazepine and analogs: new centrally acting 5-HT1A receptor agonists. J Med Chem. 1992 Oct 30;35(22):3984-90. DMDOPVM RU https://pubmed.ncbi.nlm.nih.gov/1433207 DMOGZUK DI DMOGZUK DMOGZUK DN 3-butyl-3-ethyl-1-phenylazetidine-2,4-dione DMOGZUK MI TTPLTSQ DMOGZUK MN Neutrophil elastase (NE) DMOGZUK MT DTT DMOGZUK MA Inhibitor DMOGZUK RN 4-Oxo-beta-lactams (azetidine-2,4-diones) are potent and selective inhibitors of human leukocyte elastase. J Med Chem. 2010 Jan 14;53(1):241-53. DMOGZUK RU https://pubmed.ncbi.nlm.nih.gov/19904934 DM95XWR DI DM95XWR DM95XWR DN 3-butylaminocarbonyl-6-ethyl-4-quinolone DM95XWR MI TT1MPAY DM95XWR MN GABA(A) receptor alpha-1 (GABRA1) DM95XWR MT DTT DM95XWR MA Inhibitor DM95XWR RN 4-quinolone derivatives: high-affinity ligands at the benzodiazepine site of brain GABA A receptors. synthesis, pharmacology, and pharmacophore mod... J Med Chem. 2006 Apr 20;49(8):2526-33. DM95XWR RU https://pubmed.ncbi.nlm.nih.gov/16610795 DM95XWR DI DM95XWR DM95XWR DN 3-butylaminocarbonyl-6-ethyl-4-quinolone DM95XWR MI TTZA1NY DM95XWR MN GABA(A) receptor beta-2 (GABRB2) DM95XWR MT DTT DM95XWR MA Inhibitor DM95XWR RN 4-quinolone derivatives: high-affinity ligands at the benzodiazepine site of brain GABA A receptors. synthesis, pharmacology, and pharmacophore mod... J Med Chem. 2006 Apr 20;49(8):2526-33. DM95XWR RU https://pubmed.ncbi.nlm.nih.gov/16610795 DM95XWR DI DM95XWR DM95XWR DN 3-butylaminocarbonyl-6-ethyl-4-quinolone DM95XWR MI TT06RH5 DM95XWR MN GABA(A) receptor gamma-2 (GABRG2) DM95XWR MT DTT DM95XWR MA Inhibitor DM95XWR RN 4-quinolone derivatives: high-affinity ligands at the benzodiazepine site of brain GABA A receptors. synthesis, pharmacology, and pharmacophore mod... J Med Chem. 2006 Apr 20;49(8):2526-33. DM95XWR RU https://pubmed.ncbi.nlm.nih.gov/16610795 DM95XWR DI DM95XWR DM95XWR DN 3-butylaminocarbonyl-6-ethyl-4-quinolone DM95XWR MI TTNJYV2 DM95XWR MN Gamma-aminobutyric acid receptor (GAR) DM95XWR MT DTT DM95XWR MA Inhibitor DM95XWR RN 4-quinolone derivatives: high-affinity ligands at the benzodiazepine site of brain GABA A receptors. synthesis, pharmacology, and pharmacophore mod... J Med Chem. 2006 Apr 20;49(8):2526-33. DM95XWR RU https://pubmed.ncbi.nlm.nih.gov/16610795 DMP6TLY DI DMP6TLY DMP6TLY DN 3-Carbamoyl-6-chloro-1H-indole-2-carboxylic acid DMP6TLY MI TTLD29N DMP6TLY MN Glutamate receptor ionotropic NMDA 1 (NMDAR1) DMP6TLY MT DTT DMP6TLY MA Inhibitor DMP6TLY RN 2-carboxy indolines and indoles as potential glycine/NMDA antagonists: effect of five-membered ring conformation on affinity. Bioorg. Med. Chem. Lett. 2(12):1627-1630 (1992). DMP6TLY RU http://www.sciencedirect.com/science/article/pii/S0960894X00804448 DM530OW DI DM530OW DM530OW DN 3'-carbamoylbiphenyl-3-yl 6-phenylhexylcarbamate DM530OW MI TTDP1UC DM530OW MN Fatty acid amide hydrolase (FAAH) DM530OW MT DTT DM530OW MA Inhibitor DM530OW RN Discovery and development of fatty acid amide hydrolase (FAAH) inhibitors. J Med Chem. 2008 Dec 11;51(23):7327-43. DM530OW RU https://pubmed.ncbi.nlm.nih.gov/18983142 DMHUBT5 DI DMHUBT5 DMHUBT5 DN 3-Carbazol-9-yl-propionic acid DMHUBT5 MI TTHWMFZ DMHUBT5 MN Fatty acid-binding protein 4 (FABP4) DMHUBT5 MT DTT DMHUBT5 MA Inhibitor DMHUBT5 RN Discovery of inhibitors of human adipocyte fatty acid-binding protein, a potential type 2 diabetes target. Bioorg Med Chem Lett. 2004 Sep 6;14(17):4445-8. DMHUBT5 RU https://pubmed.ncbi.nlm.nih.gov/15357969 DMRUX93 DI DMRUX93 DMRUX93 DN 3-carboxy-6-ethyl-4-quinolone DMRUX93 MI TT1MPAY DMRUX93 MN GABA(A) receptor alpha-1 (GABRA1) DMRUX93 MT DTT DMRUX93 MA Inhibitor DMRUX93 RN 4-quinolone derivatives: high-affinity ligands at the benzodiazepine site of brain GABA A receptors. synthesis, pharmacology, and pharmacophore mod... J Med Chem. 2006 Apr 20;49(8):2526-33. DMRUX93 RU https://pubmed.ncbi.nlm.nih.gov/16610795 DMRUX93 DI DMRUX93 DMRUX93 DN 3-carboxy-6-ethyl-4-quinolone DMRUX93 MI TTZA1NY DMRUX93 MN GABA(A) receptor beta-2 (GABRB2) DMRUX93 MT DTT DMRUX93 MA Inhibitor DMRUX93 RN 4-quinolone derivatives: high-affinity ligands at the benzodiazepine site of brain GABA A receptors. synthesis, pharmacology, and pharmacophore mod... J Med Chem. 2006 Apr 20;49(8):2526-33. DMRUX93 RU https://pubmed.ncbi.nlm.nih.gov/16610795 DMRUX93 DI DMRUX93 DMRUX93 DN 3-carboxy-6-ethyl-4-quinolone DMRUX93 MI TT06RH5 DMRUX93 MN GABA(A) receptor gamma-2 (GABRG2) DMRUX93 MT DTT DMRUX93 MA Inhibitor DMRUX93 RN 4-quinolone derivatives: high-affinity ligands at the benzodiazepine site of brain GABA A receptors. synthesis, pharmacology, and pharmacophore mod... J Med Chem. 2006 Apr 20;49(8):2526-33. DMRUX93 RU https://pubmed.ncbi.nlm.nih.gov/16610795 DMRUX93 DI DMRUX93 DMRUX93 DN 3-carboxy-6-ethyl-4-quinolone DMRUX93 MI TTNJYV2 DMRUX93 MN Gamma-aminobutyric acid receptor (GAR) DMRUX93 MT DTT DMRUX93 MA Inhibitor DMRUX93 RN 4-quinolone derivatives: high-affinity ligands at the benzodiazepine site of brain GABA A receptors. synthesis, pharmacology, and pharmacophore mod... J Med Chem. 2006 Apr 20;49(8):2526-33. DMRUX93 RU https://pubmed.ncbi.nlm.nih.gov/16610795 DM9OGNE DI DM9OGNE DM9OGNE DN 3-chloro-1-(4-hydroxyphenyl)propan-1-one DM9OGNE MI TTT2LD9 DM9OGNE MN GABA transaminase (ABAT) DM9OGNE MT DTT DM9OGNE MA Inhibitor DM9OGNE RN Inactivation of GABA transaminase by 3-chloro-1-(4-hydroxyphenyl)propan-1-one. Bioorg Med Chem Lett. 2009 Feb 1;19(3):731-4. DM9OGNE RU https://pubmed.ncbi.nlm.nih.gov/19138517 DM3R8OM DI DM3R8OM DM3R8OM DN 3-CHLORO-2-(4-HYDROXYPHENYL)-2H-INDAZOL-5-OL DM3R8OM MI TTZAYWL DM3R8OM MN Estrogen receptor (ESR) DM3R8OM MT DTT DM3R8OM MA Inhibitor DM3R8OM RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DM3R8OM RU https://pubmed.ncbi.nlm.nih.gov/10592235 DMZ5JFG DI DMZ5JFG DMZ5JFG DN 3-chloro-4-(4-chloro-2-hydroxyphenoxy)benzamide DMZ5JFG MI TTNX2CS DMZ5JFG MN Plasmodium Enoyl-ACP reductase (Malaria fabI) DMZ5JFG MT DTT DMZ5JFG MA Inhibitor DMZ5JFG RN Synthesis, biological activity, and X-ray crystal structural analysis of diaryl ether inhibitors of malarial enoyl acyl carrier protein reductase. ... Bioorg Med Chem Lett. 2005 Dec 1;15(23):5247-52. DMZ5JFG RU https://pubmed.ncbi.nlm.nih.gov/16198563 DMER4U1 DI DMER4U1 DMER4U1 DN 3-chloro-4-(4-hydroxyphenyl)salicylaldoxime DMER4U1 MI TTZAYWL DMER4U1 MN Estrogen receptor (ESR) DMER4U1 MT DTT DMER4U1 MA Inhibitor DMER4U1 RN Monoaryl-substituted salicylaldoximes as ligands for estrogen receptor beta. J Med Chem. 2008 Mar 13;51(5):1344-51. DMER4U1 RU https://pubmed.ncbi.nlm.nih.gov/18269232 DMER4U1 DI DMER4U1 DMER4U1 DN 3-chloro-4-(4-hydroxyphenyl)salicylaldoxime DMER4U1 MI TTOM3J0 DMER4U1 MN Estrogen receptor beta (ESR2) DMER4U1 MT DTT DMER4U1 MA Inhibitor DMER4U1 RN Monoaryl-substituted salicylaldoximes as ligands for estrogen receptor beta. J Med Chem. 2008 Mar 13;51(5):1344-51. DMER4U1 RU https://pubmed.ncbi.nlm.nih.gov/18269232 DMNQF03 DI DMNQF03 DMNQF03 DN 3-chloro-4-(o-tolyloxy)benzonitrile DMNQF03 MI TTKPW01 DMNQF03 MN Androgen receptor messenger RNA (AR mRNA) DMNQF03 MT DTT DMNQF03 MA Inhibitor DMNQF03 RN Diphenyl ethers as androgen receptor antagonists for the topical suppression of sebum production. Bioorg Med Chem Lett. 2009 Apr 15;19(8):2176-8. DMNQF03 RU https://pubmed.ncbi.nlm.nih.gov/19286380 DM6Z3I8 DI DM6Z3I8 DM6Z3I8 DN 3-chloro-4-(o-tolylthio)benzonitrile DM6Z3I8 MI TTKPW01 DM6Z3I8 MN Androgen receptor messenger RNA (AR mRNA) DM6Z3I8 MT DTT DM6Z3I8 MA Inhibitor DM6Z3I8 RN 4-(Alkylthio)- and 4-(arylthio)-benzonitrile derivatives as androgen receptor antagonists for the topical suppression of sebum production. Bioorg Med Chem Lett. 2009 Mar 1;19(5):1310-3. DM6Z3I8 RU https://pubmed.ncbi.nlm.nih.gov/19201190 DMSB5IQ DI DMSB5IQ DMSB5IQ DN 3-Chloro-4-hydrazino-benzenesulfonamide DMSB5IQ MI TTHQPL7 DMSB5IQ MN Carbonic anhydrase I (CA-I) DMSB5IQ MT DTT DMSB5IQ MA Inhibitor DMSB5IQ RN Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/membrane-associated carbonic anhydrase isozymes I, II, and IX with sulfonamide... J Med Chem. 2005 Mar 24;48(6):2121-5. DMSB5IQ RU https://pubmed.ncbi.nlm.nih.gov/15771455 DMSB5IQ DI DMSB5IQ DMSB5IQ DN 3-Chloro-4-hydrazino-benzenesulfonamide DMSB5IQ MI TTANPDJ DMSB5IQ MN Carbonic anhydrase II (CA-II) DMSB5IQ MT DTT DMSB5IQ MA Inhibitor DMSB5IQ RN Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/membrane-associated carbonic anhydrase isozymes I, II, and IX with sulfonamide... J Med Chem. 2005 Mar 24;48(6):2121-5. DMSB5IQ RU https://pubmed.ncbi.nlm.nih.gov/15771455 DMSB5IQ DI DMSB5IQ DMSB5IQ DN 3-Chloro-4-hydrazino-benzenesulfonamide DMSB5IQ MI TT2LVK8 DMSB5IQ MN Carbonic anhydrase IX (CA-IX) DMSB5IQ MT DTT DMSB5IQ MA Inhibitor DMSB5IQ RN Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/membrane-associated carbonic anhydrase isozymes I, II, and IX with sulfonamide... J Med Chem. 2005 Mar 24;48(6):2121-5. DMSB5IQ RU https://pubmed.ncbi.nlm.nih.gov/15771455 DMBMH96 DI DMBMH96 DMBMH96 DN 3-chloro-5-(2-methylquinolin-7-yl)benzonitrile DMBMH96 MI TTHS256 DMBMH96 MN Metabotropic glutamate receptor 5 (mGluR5) DMBMH96 MT DTT DMBMH96 MA Inhibitor DMBMH96 RN Rational design of 7-arylquinolines as non-competitive metabotropic glutamate receptor subtype 5 antagonists. Bioorg Med Chem Lett. 2007 Aug 15;17(16):4415-8. DMBMH96 RU https://pubmed.ncbi.nlm.nih.gov/17590335 DMCD901 DI DMCD901 DMCD901 DN 3-Chloro-9H-beta-carboline DMCD901 MI TT1MPAY DMCD901 MN GABA(A) receptor alpha-1 (GABRA1) DMCD901 MT DTT DMCD901 MA Inhibitor DMCD901 RN Synthesis of novel 3-substituted beta-carbolines as benzodiazepine receptor ligands: probing the benzodiazepine receptor pharmacophore. J Med Chem. 1988 Sep;31(9):1854-61. DMCD901 RU https://pubmed.ncbi.nlm.nih.gov/2842507 DMCD901 DI DMCD901 DMCD901 DN 3-Chloro-9H-beta-carboline DMCD901 MI TTNJYV2 DMCD901 MN Gamma-aminobutyric acid receptor (GAR) DMCD901 MT DTT DMCD901 MA Inhibitor DMCD901 RN Synthesis of novel 3-substituted beta-carbolines as benzodiazepine receptor ligands: probing the benzodiazepine receptor pharmacophore. J Med Chem. 1988 Sep;31(9):1854-61. DMCD901 RU https://pubmed.ncbi.nlm.nih.gov/2842507 DM5J1TX DI DM5J1TX DM5J1TX DN 3-Chloroboldine DM5J1TX MI TTZFYLI DM5J1TX MN Dopamine D1 receptor (D1R) DM5J1TX MT DTT DM5J1TX MA Inhibitor DM5J1TX RN Halogenated boldine derivatives with enhanced monoamine receptor selectivity. J Nat Prod. 2000 Apr;63(4):480-4. DM5J1TX RU https://pubmed.ncbi.nlm.nih.gov/10785418 DM5J1TX DI DM5J1TX DM5J1TX DN 3-Chloroboldine DM5J1TX MI TTEX248 DM5J1TX MN Dopamine D2 receptor (D2R) DM5J1TX MT DTT DM5J1TX MA Inhibitor DM5J1TX RN Halogenated boldine derivatives with enhanced monoamine receptor selectivity. J Nat Prod. 2000 Apr;63(4):480-4. DM5J1TX RU https://pubmed.ncbi.nlm.nih.gov/10785418 DMIEZGD DI DMIEZGD DMIEZGD DN 3-Chloro-N-(2-methyl-1H-indol-5-yl)benzamide DMIEZGD MI TT3WG5C DMIEZGD MN Monoamine oxidase type A (MAO-A) DMIEZGD MT DTT DMIEZGD MA Inhibitor DMIEZGD RN Inhibition of monoamine oxidase by indole and benzofuran derivatives. Eur J Med Chem. 2010 Oct;45(10):4458-66. DMIEZGD RU https://pubmed.ncbi.nlm.nih.gov/20674099 DMIEZGD DI DMIEZGD DMIEZGD DN 3-Chloro-N-(2-methyl-1H-indol-5-yl)benzamide DMIEZGD MI TTGP7BY DMIEZGD MN Monoamine oxidase type B (MAO-B) DMIEZGD MT DTT DMIEZGD MA Inhibitor DMIEZGD RN Inhibition of monoamine oxidase by indole and benzofuran derivatives. Eur J Med Chem. 2010 Oct;45(10):4458-66. DMIEZGD RU https://pubmed.ncbi.nlm.nih.gov/20674099 DMV8TNO DI DMV8TNO DMV8TNO DN 3-chloro-N-(3-isobutyramidophenyl)benzamide DMV8TNO MI TTHS256 DMV8TNO MN Metabotropic glutamate receptor 5 (mGluR5) DMV8TNO MT DTT DMV8TNO MA Inhibitor DMV8TNO RN Synthesis and SAR of novel, non-MPEP chemotype mGluR5 NAMs identified by functional HTS. Bioorg Med Chem Lett. 2009 Dec 1;19(23):6502-6. DMV8TNO RU https://pubmed.ncbi.nlm.nih.gov/19875287 DMBVCLY DI DMBVCLY DMBVCLY DN 3-chloro-N-(4-(phenyldiazenyl)phenyl)benzamide DMBVCLY MI TTEAID7 DMBVCLY MN Trypanosoma Cruzipain (Trypano CYSP) DMBVCLY MT DTT DMBVCLY MA Inhibitor DMBVCLY RN Quantitative analyses of aggregation, autofluorescence, and reactivity artifacts in a screen for inhibitors of a thiol protease. J Med Chem. 2010 Jan 14;53(1):37-51. DMBVCLY RU https://pubmed.ncbi.nlm.nih.gov/19908840 DM4EL6M DI DM4EL6M DM4EL6M DN 3-chloro-N-(4-methylthiazol-2-yl)benzamide DM4EL6M MI TTHS256 DM4EL6M MN Metabotropic glutamate receptor 5 (mGluR5) DM4EL6M MT DTT DM4EL6M MA Inhibitor DM4EL6M RN Design and synthesis of noncompetitive metabotropic glutamate receptor subtype 5 antagonists. Bioorg Med Chem Lett. 2006 Jul 1;16(13):3371-5. DM4EL6M RU https://pubmed.ncbi.nlm.nih.gov/16678408 DMAWC7S DI DMAWC7S DMAWC7S DN 3-Chloro-N-(4-phenyl-thiazol-2-yl)-benzamide DMAWC7S MI TTK25J1 DMAWC7S MN Adenosine A1 receptor (ADORA1) DMAWC7S MT DTT DMAWC7S MA Inhibitor DMAWC7S RN Substituted 4-phenyl-2-(phenylcarboxamido)-1,3-thiazole derivatives as antagonists for the adenosine A(1) receptor. Bioorg Med Chem Lett. 2001 Aug 6;11(15):2017-9. DMAWC7S RU https://pubmed.ncbi.nlm.nih.gov/11454470 DMLC2I6 DI DMLC2I6 DMLC2I6 DN 3-chloro-N-(6-chloropyridin-2-yl)benzamide DMLC2I6 MI TTHS256 DMLC2I6 MN Metabotropic glutamate receptor 5 (mGluR5) DMLC2I6 MT DTT DMLC2I6 MA Inhibitor DMLC2I6 RN Design and synthesis of noncompetitive metabotropic glutamate receptor subtype 5 antagonists. Bioorg Med Chem Lett. 2006 Jul 1;16(13):3371-5. DMLC2I6 RU https://pubmed.ncbi.nlm.nih.gov/16678408 DMLJGF1 DI DMLJGF1 DMLJGF1 DN 3-chloro-N-(6-methylpyridin-2-yl)benzamide DMLJGF1 MI TTHS256 DMLJGF1 MN Metabotropic glutamate receptor 5 (mGluR5) DMLJGF1 MT DTT DMLJGF1 MA Inhibitor DMLJGF1 RN Structure-activity relationships comparing N-(6-methylpyridin-yl)-substituted aryl amides to 2-methyl-6-(substituted-arylethynyl)pyridines or 2-met... J Med Chem. 2009 Jun 11;52(11):3563-75. DMLJGF1 RU https://pubmed.ncbi.nlm.nih.gov/19445453 DMQCVKO DI DMQCVKO DMQCVKO DN 3-chlorophenyl 10H-phenothiazine-10-carboxylate DMQCVKO MI TTEB0GD DMQCVKO MN Cholinesterase (BCHE) DMQCVKO MT DTT DMQCVKO MA Inhibitor DMQCVKO RN Carbamates with differential mechanism of inhibition toward acetylcholinesterase and butyrylcholinesterase. J Med Chem. 2008 Jul 24;51(14):4200-12. DMQCVKO RU https://pubmed.ncbi.nlm.nih.gov/18570368 DMZ0F7E DI DMZ0F7E DMZ0F7E DN 3-chlorophenyl 2-oxo-2H-chromene-3-carboxylate DMZ0F7E MI TT6L509 DMZ0F7E MN Coagulation factor IIa (F2) DMZ0F7E MT DTT DMZ0F7E MA Inhibitor DMZ0F7E RN 3,6-disubstituted coumarins as mechanism-based inhibitors of thrombin and factor Xa. J Med Chem. 2005 Dec 1;48(24):7592-603. DMZ0F7E RU https://pubmed.ncbi.nlm.nih.gov/16302799 DMZ0F7E DI DMZ0F7E DMZ0F7E DN 3-chlorophenyl 2-oxo-2H-chromene-3-carboxylate DMZ0F7E MI TTCIHJA DMZ0F7E MN Coagulation factor Xa (F10) DMZ0F7E MT DTT DMZ0F7E MA Inhibitor DMZ0F7E RN 3,6-disubstituted coumarins as mechanism-based inhibitors of thrombin and factor Xa. J Med Chem. 2005 Dec 1;48(24):7592-603. DMZ0F7E RU https://pubmed.ncbi.nlm.nih.gov/16302799 DMJ2SZ1 DI DMJ2SZ1 DMJ2SZ1 DN 3-chlorophenyl 4-butoxybenzylcarbamate DMJ2SZ1 MI TTDP1UC DMJ2SZ1 MN Fatty acid amide hydrolase (FAAH) DMJ2SZ1 MT DTT DMJ2SZ1 MA Inhibitor DMJ2SZ1 RN Oxime carbamate--discovery of a series of novel FAAH inhibitors. Bioorg Med Chem Lett. 2010 Feb 1;20(3):1272-7. DMJ2SZ1 RU https://pubmed.ncbi.nlm.nih.gov/20036536 DMJ4SDM DI DMJ4SDM DMJ4SDM DN 3-chlorotyrosine DMJ4SDM MI TTUHP71 DMJ4SDM MN Tyrosine 3-monooxygenase (TH) DMJ4SDM MT DTT DMJ4SDM MA Inhibitor DMJ4SDM RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1243). DMJ4SDM RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1243 DM78FWG DI DM78FWG DM78FWG DN 3-cis-p-coumaroyl maslinic acid DM78FWG MI TTIU7X1 DM78FWG MN Herpes simplex virus DNA polymerase UL30 (HSV UL30) DM78FWG MT DTT DM78FWG MA Inhibitor DM78FWG RN DNA polymerase beta inhibitors from Tetracera boiviniana. J Nat Prod. 1999 Dec;62(12):1660-3. DM78FWG RU https://pubmed.ncbi.nlm.nih.gov/10654414 DMF1PIW DI DMF1PIW DMF1PIW DN 3-cyano-5-fluoro-N-(3-fluorophenyl)benzamide DMF1PIW MI TTHS256 DMF1PIW MN Metabotropic glutamate receptor 5 (mGluR5) DMF1PIW MT DTT DMF1PIW MA Inhibitor DMF1PIW RN 3-Cyano-5-fluoro-N-arylbenzamides as negative allosteric modulators of mGlu(5): Identification of easily prepared tool compounds with CNS exposure ... Bioorg Med Chem Lett. 2010 Aug 1;20(15):4390-4. DMF1PIW RU https://pubmed.ncbi.nlm.nih.gov/20598884 DMBA4XN DI DMBA4XN DMBA4XN DN 3-cyano-5-fluoro-N-(pyridin-2-yl)benzamide DMBA4XN MI TTHS256 DMBA4XN MN Metabotropic glutamate receptor 5 (mGluR5) DMBA4XN MT DTT DMBA4XN MA Inhibitor DMBA4XN RN 3-Cyano-5-fluoro-N-arylbenzamides as negative allosteric modulators of mGlu(5): Identification of easily prepared tool compounds with CNS exposure ... Bioorg Med Chem Lett. 2010 Aug 1;20(15):4390-4. DMBA4XN RU https://pubmed.ncbi.nlm.nih.gov/20598884 DMF097H DI DMF097H DMF097H DN 3-cyano-5-fluoro-N-m-tolylbenzamide DMF097H MI TTHS256 DMF097H MN Metabotropic glutamate receptor 5 (mGluR5) DMF097H MT DTT DMF097H MA Inhibitor DMF097H RN 3-Cyano-5-fluoro-N-arylbenzamides as negative allosteric modulators of mGlu(5): Identification of easily prepared tool compounds with CNS exposure ... Bioorg Med Chem Lett. 2010 Aug 1;20(15):4390-4. DMF097H RU https://pubmed.ncbi.nlm.nih.gov/20598884 DMIZ8RC DI DMIZ8RC DMIZ8RC DN 3-cyano-5-fluoro-N-phenylbenzamide DMIZ8RC MI TTHS256 DMIZ8RC MN Metabotropic glutamate receptor 5 (mGluR5) DMIZ8RC MT DTT DMIZ8RC MA Inhibitor DMIZ8RC RN 3-Cyano-5-fluoro-N-arylbenzamides as negative allosteric modulators of mGlu(5): Identification of easily prepared tool compounds with CNS exposure ... Bioorg Med Chem Lett. 2010 Aug 1;20(15):4390-4. DMIZ8RC RU https://pubmed.ncbi.nlm.nih.gov/20598884 DMH7FC9 DI DMH7FC9 DMH7FC9 DN 3-cyano-N-(1,3-diphenyl-1H-pyrazol-5-yl)benzamide DMH7FC9 MI TTHS256 DMH7FC9 MN Metabotropic glutamate receptor 5 (mGluR5) DMH7FC9 MT DTT DMH7FC9 MA Inhibitor DMH7FC9 RN Discovery of positive allosteric modulators for the metabotropic glutamate receptor subtype 5 from a series of N-(1,3-diphenyl-1H- pyrazol-5-yl)benzamides that potentiate receptor function in vivo. JMed Chem. 2004 Nov 18;47(24):5825-8. DMH7FC9 RU https://pubmed.ncbi.nlm.nih.gov/15537338 DM3EIWC DI DM3EIWC DM3EIWC DN 3-cyano-N-(1,4-diphenyl-1H-pyrazol-5-yl)benzamide DM3EIWC MI TTHS256 DM3EIWC MN Metabotropic glutamate receptor 5 (mGluR5) DM3EIWC MT DTT DM3EIWC MA Inhibitor DM3EIWC RN Substituent effects of N-(1,3-diphenyl-1H-pyrazol-5-yl)benzamides on positive allosteric modulation of the metabotropic glutamate-5 receptor in rat... J Med Chem. 2006 Jun 1;49(11):3332-44. DM3EIWC RU https://pubmed.ncbi.nlm.nih.gov/16722652 DMRD8VM DI DMRD8VM DMRD8VM DN 3-cyano-N-(3-cyanophenyl)-5-fluorobenzamide DMRD8VM MI TTHS256 DMRD8VM MN Metabotropic glutamate receptor 5 (mGluR5) DMRD8VM MT DTT DMRD8VM MA Inhibitor DMRD8VM RN 3-Cyano-5-fluoro-N-arylbenzamides as negative allosteric modulators of mGlu(5): Identification of easily prepared tool compounds with CNS exposure ... Bioorg Med Chem Lett. 2010 Aug 1;20(15):4390-4. DMRD8VM RU https://pubmed.ncbi.nlm.nih.gov/20598884 DMFUT57 DI DMFUT57 DMFUT57 DN 3-cyano-N-(3-ethylphenyl)-5-fluorobenzamide DMFUT57 MI TTHS256 DMFUT57 MN Metabotropic glutamate receptor 5 (mGluR5) DMFUT57 MT DTT DMFUT57 MA Inhibitor DMFUT57 RN 3-Cyano-5-fluoro-N-arylbenzamides as negative allosteric modulators of mGlu(5): Identification of easily prepared tool compounds with CNS exposure ... Bioorg Med Chem Lett. 2010 Aug 1;20(15):4390-4. DMFUT57 RU https://pubmed.ncbi.nlm.nih.gov/20598884 DM9FEMV DI DM9FEMV DM9FEMV DN 3-cyano-N-(3-ethynylphenyl)-5-fluorobenzamide DM9FEMV MI TTHS256 DM9FEMV MN Metabotropic glutamate receptor 5 (mGluR5) DM9FEMV MT DTT DM9FEMV MA Inhibitor DM9FEMV RN 3-Cyano-5-fluoro-N-arylbenzamides as negative allosteric modulators of mGlu(5): Identification of easily prepared tool compounds with CNS exposure ... Bioorg Med Chem Lett. 2010 Aug 1;20(15):4390-4. DM9FEMV RU https://pubmed.ncbi.nlm.nih.gov/20598884 DMUB9XW DI DMUB9XW DMUB9XW DN 3-cyano-N-(6-ethylpyridin-2-yl)-5-fluorobenzamide DMUB9XW MI TTHS256 DMUB9XW MN Metabotropic glutamate receptor 5 (mGluR5) DMUB9XW MT DTT DMUB9XW MA Inhibitor DMUB9XW RN 3-Cyano-5-fluoro-N-arylbenzamides as negative allosteric modulators of mGlu(5): Identification of easily prepared tool compounds with CNS exposure ... Bioorg Med Chem Lett. 2010 Aug 1;20(15):4390-4. DMUB9XW RU https://pubmed.ncbi.nlm.nih.gov/20598884 DMTDEYL DI DMTDEYL DMTDEYL DN 3-cyano-N-(6-methylpyridin-2-yl)benzamide DMTDEYL MI TTHS256 DMTDEYL MN Metabotropic glutamate receptor 5 (mGluR5) DMTDEYL MT DTT DMTDEYL MA Inhibitor DMTDEYL RN Structure-activity relationships comparing N-(6-methylpyridin-yl)-substituted aryl amides to 2-methyl-6-(substituted-arylethynyl)pyridines or 2-met... J Med Chem. 2009 Jun 11;52(11):3563-75. DMTDEYL RU https://pubmed.ncbi.nlm.nih.gov/19445453 DMPWR90 DI DMPWR90 DMPWR90 DN 3-cyanophenylboronic acid DMPWR90 MI TTDP1UC DMPWR90 MN Fatty acid amide hydrolase (FAAH) DMPWR90 MT DTT DMPWR90 MA Inhibitor DMPWR90 RN Discovery of boronic acids as novel and potent inhibitors of fatty acid amide hydrolase. J Med Chem. 2008 Nov 27;51(22):7057-60. DMPWR90 RU https://pubmed.ncbi.nlm.nih.gov/18983140 DMJSOTE DI DMJSOTE DMJSOTE DN 3-Cyclohexanesulfonyl-heptanoic acid hydroxyamide DMJSOTE MI TTMX39J DMJSOTE MN Matrix metalloproteinase-1 (MMP-1) DMJSOTE MT DTT DMJSOTE MA Inhibitor DMJSOTE RN Hydroxamic acid derivatives as potent peptide deformylase inhibitors and antibacterial agents. J Med Chem. 2000 Jun 15;43(12):2324-31. DMJSOTE RU https://pubmed.ncbi.nlm.nih.gov/10882358 DMJSOTE DI DMJSOTE DMJSOTE DN 3-Cyclohexanesulfonyl-heptanoic acid hydroxyamide DMJSOTE MI TTXZ0KQ DMJSOTE MN Matrix metalloproteinase-12 (MMP-12) DMJSOTE MT DTT DMJSOTE MA Inhibitor DMJSOTE RN Hydroxamic acid derivatives as potent peptide deformylase inhibitors and antibacterial agents. J Med Chem. 2000 Jun 15;43(12):2324-31. DMJSOTE RU https://pubmed.ncbi.nlm.nih.gov/10882358 DMJSOTE DI DMJSOTE DMJSOTE DN 3-Cyclohexanesulfonyl-heptanoic acid hydroxyamide DMJSOTE MI TTHY57M DMJSOTE MN Matrix metalloproteinase-13 (MMP-13) DMJSOTE MT DTT DMJSOTE MA Inhibitor DMJSOTE RN Hydroxamic acid derivatives as potent peptide deformylase inhibitors and antibacterial agents. J Med Chem. 2000 Jun 15;43(12):2324-31. DMJSOTE RU https://pubmed.ncbi.nlm.nih.gov/10882358 DMJSOTE DI DMJSOTE DMJSOTE DN 3-Cyclohexanesulfonyl-heptanoic acid hydroxyamide DMJSOTE MI TTMTWOS DMJSOTE MN Matrix metalloproteinase-7 (MMP-7) DMJSOTE MT DTT DMJSOTE MA Inhibitor DMJSOTE RN Hydroxamic acid derivatives as potent peptide deformylase inhibitors and antibacterial agents. J Med Chem. 2000 Jun 15;43(12):2324-31. DMJSOTE RU https://pubmed.ncbi.nlm.nih.gov/10882358 DMWMFZ3 DI DMWMFZ3 DMWMFZ3 DN 3-Cyclohexyl-1-propyl-piperidine hydrochloride DMWMFZ3 MI TTEX248 DMWMFZ3 MN Dopamine D2 receptor (D2R) DMWMFZ3 MT DTT DMWMFZ3 MA Inhibitor DMWMFZ3 RN New N-n-propyl-substituted 3-aryl- and 3-cyclohexylpiperidines as partial agonists at the D4 dopamine receptor. J Med Chem. 2003 Jan 2;46(1):161-8. DMWMFZ3 RU https://pubmed.ncbi.nlm.nih.gov/12502370 DMCQ6J8 DI DMCQ6J8 DMCQ6J8 DN 3-Cyclohexylethynyl-6,7-dimethoxy-quinoline DMCQ6J8 MI TT8FYO9 DMCQ6J8 MN Platelet-derived growth factor receptor alpha (PDGFRA) DMCQ6J8 MT DTT DMCQ6J8 MA Inhibitor DMCQ6J8 RN A new series of PDGF receptor tyrosine kinase inhibitors: 3-substituted quinoline derivatives. J Med Chem. 1994 Jul 8;37(14):2129-37. DMCQ6J8 RU https://pubmed.ncbi.nlm.nih.gov/8035419 DMCQ6J8 DI DMCQ6J8 DMCQ6J8 DN 3-Cyclohexylethynyl-6,7-dimethoxy-quinoline DMCQ6J8 MI TTI7421 DMCQ6J8 MN Platelet-derived growth factor receptor beta (PDGFRB) DMCQ6J8 MT DTT DMCQ6J8 MA Inhibitor DMCQ6J8 RN A new series of PDGF receptor tyrosine kinase inhibitors: 3-substituted quinoline derivatives. J Med Chem. 1994 Jul 8;37(14):2129-37. DMCQ6J8 RU https://pubmed.ncbi.nlm.nih.gov/8035419 DM1FSZM DI DM1FSZM DM1FSZM DN 3-Cyclopent-1-enyl-6,7-dimethoxy-quinoline DM1FSZM MI TT8FYO9 DM1FSZM MN Platelet-derived growth factor receptor alpha (PDGFRA) DM1FSZM MT DTT DM1FSZM MA Inhibitor DM1FSZM RN A new series of PDGF receptor tyrosine kinase inhibitors: 3-substituted quinoline derivatives. J Med Chem. 1994 Jul 8;37(14):2129-37. DM1FSZM RU https://pubmed.ncbi.nlm.nih.gov/8035419 DM1FSZM DI DM1FSZM DM1FSZM DN 3-Cyclopent-1-enyl-6,7-dimethoxy-quinoline DM1FSZM MI TTI7421 DM1FSZM MN Platelet-derived growth factor receptor beta (PDGFRB) DM1FSZM MT DTT DM1FSZM MA Inhibitor DM1FSZM RN A new series of PDGF receptor tyrosine kinase inhibitors: 3-substituted quinoline derivatives. J Med Chem. 1994 Jul 8;37(14):2129-37. DM1FSZM RU https://pubmed.ncbi.nlm.nih.gov/8035419 DMEL8S5 DI DMEL8S5 DMEL8S5 DN 3-cyclopentoxycarbonyl-6-ethyl-4-quinolone DMEL8S5 MI TT1MPAY DMEL8S5 MN GABA(A) receptor alpha-1 (GABRA1) DMEL8S5 MT DTT DMEL8S5 MA Inhibitor DMEL8S5 RN 4-quinolone derivatives: high-affinity ligands at the benzodiazepine site of brain GABA A receptors. synthesis, pharmacology, and pharmacophore mod... J Med Chem. 2006 Apr 20;49(8):2526-33. DMEL8S5 RU https://pubmed.ncbi.nlm.nih.gov/16610795 DMEL8S5 DI DMEL8S5 DMEL8S5 DN 3-cyclopentoxycarbonyl-6-ethyl-4-quinolone DMEL8S5 MI TTZA1NY DMEL8S5 MN GABA(A) receptor beta-2 (GABRB2) DMEL8S5 MT DTT DMEL8S5 MA Inhibitor DMEL8S5 RN 4-quinolone derivatives: high-affinity ligands at the benzodiazepine site of brain GABA A receptors. synthesis, pharmacology, and pharmacophore mod... J Med Chem. 2006 Apr 20;49(8):2526-33. DMEL8S5 RU https://pubmed.ncbi.nlm.nih.gov/16610795 DMEL8S5 DI DMEL8S5 DMEL8S5 DN 3-cyclopentoxycarbonyl-6-ethyl-4-quinolone DMEL8S5 MI TT06RH5 DMEL8S5 MN GABA(A) receptor gamma-2 (GABRG2) DMEL8S5 MT DTT DMEL8S5 MA Inhibitor DMEL8S5 RN 4-quinolone derivatives: high-affinity ligands at the benzodiazepine site of brain GABA A receptors. synthesis, pharmacology, and pharmacophore mod... J Med Chem. 2006 Apr 20;49(8):2526-33. DMEL8S5 RU https://pubmed.ncbi.nlm.nih.gov/16610795 DMEL8S5 DI DMEL8S5 DMEL8S5 DN 3-cyclopentoxycarbonyl-6-ethyl-4-quinolone DMEL8S5 MI TTNJYV2 DMEL8S5 MN Gamma-aminobutyric acid receptor (GAR) DMEL8S5 MT DTT DMEL8S5 MA Inhibitor DMEL8S5 RN 4-quinolone derivatives: high-affinity ligands at the benzodiazepine site of brain GABA A receptors. synthesis, pharmacology, and pharmacophore mod... J Med Chem. 2006 Apr 20;49(8):2526-33. DMEL8S5 RU https://pubmed.ncbi.nlm.nih.gov/16610795 DMS7B6T DI DMS7B6T DMS7B6T DN 3-Cyclopentyl-6,7-dimethoxy-quinoline DMS7B6T MI TT8FYO9 DMS7B6T MN Platelet-derived growth factor receptor alpha (PDGFRA) DMS7B6T MT DTT DMS7B6T MA Inhibitor DMS7B6T RN A new series of PDGF receptor tyrosine kinase inhibitors: 3-substituted quinoline derivatives. J Med Chem. 1994 Jul 8;37(14):2129-37. DMS7B6T RU https://pubmed.ncbi.nlm.nih.gov/8035419 DMS7B6T DI DMS7B6T DMS7B6T DN 3-Cyclopentyl-6,7-dimethoxy-quinoline DMS7B6T MI TTI7421 DMS7B6T MN Platelet-derived growth factor receptor beta (PDGFRB) DMS7B6T MT DTT DMS7B6T MA Inhibitor DMS7B6T RN A new series of PDGF receptor tyrosine kinase inhibitors: 3-substituted quinoline derivatives. J Med Chem. 1994 Jul 8;37(14):2129-37. DMS7B6T RU https://pubmed.ncbi.nlm.nih.gov/8035419 DMLQJ64 DI DMLQJ64 DMLQJ64 DN 3-Decanoyl-4-hydroxy-6-nonyl-pyran-2-one DMLQJ64 MI TTPLTSQ DMLQJ64 MN Neutrophil elastase (NE) DMLQJ64 MT DTT DMLQJ64 MA Inhibitor DMLQJ64 RN Inhibition of human sputum elastase by substituted 2-pyrones. J Med Chem. 1987 Jun;30(6):1017-23. DMLQJ64 RU https://pubmed.ncbi.nlm.nih.gov/3647139 DMID7TC DI DMID7TC DMID7TC DN 3-demethoxy-3D-glucopyranosylaminothiocolchicine DMID7TC MI TT1MPAY DMID7TC MN GABA(A) receptor alpha-1 (GABRA1) DMID7TC MT DTT DMID7TC MA Inhibitor DMID7TC RN 3-demethoxy-3-glycosylaminothiocolchicines: Synthesis of a new class of putative muscle relaxant compounds. J Med Chem. 2006 Sep 7;49(18):5571-7. DMID7TC RU https://pubmed.ncbi.nlm.nih.gov/16942030 DMID7TC DI DMID7TC DMID7TC DN 3-demethoxy-3D-glucopyranosylaminothiocolchicine DMID7TC MI TTZA1NY DMID7TC MN GABA(A) receptor beta-2 (GABRB2) DMID7TC MT DTT DMID7TC MA Inhibitor DMID7TC RN 3-demethoxy-3-glycosylaminothiocolchicines: Synthesis of a new class of putative muscle relaxant compounds. J Med Chem. 2006 Sep 7;49(18):5571-7. DMID7TC RU https://pubmed.ncbi.nlm.nih.gov/16942030 DMID7TC DI DMID7TC DMID7TC DN 3-demethoxy-3D-glucopyranosylaminothiocolchicine DMID7TC MI TT06RH5 DMID7TC MN GABA(A) receptor gamma-2 (GABRG2) DMID7TC MT DTT DMID7TC MA Inhibitor DMID7TC RN 3-demethoxy-3-glycosylaminothiocolchicines: Synthesis of a new class of putative muscle relaxant compounds. J Med Chem. 2006 Sep 7;49(18):5571-7. DMID7TC RU https://pubmed.ncbi.nlm.nih.gov/16942030 DMID7TC DI DMID7TC DMID7TC DN 3-demethoxy-3D-glucopyranosylaminothiocolchicine DMID7TC MI TTNJYV2 DMID7TC MN Gamma-aminobutyric acid receptor (GAR) DMID7TC MT DTT DMID7TC MA Inhibitor DMID7TC RN 3-demethoxy-3-glycosylaminothiocolchicines: Synthesis of a new class of putative muscle relaxant compounds. J Med Chem. 2006 Sep 7;49(18):5571-7. DMID7TC RU https://pubmed.ncbi.nlm.nih.gov/16942030 DMID7TC DI DMID7TC DMID7TC DN 3-demethoxy-3D-glucopyranosylaminothiocolchicine DMID7TC MI TTZ8EM9 DMID7TC MN Glycine receptor (GlyR) DMID7TC MT DTT DMID7TC MA Inhibitor DMID7TC RN 3-demethoxy-3-glycosylaminothiocolchicines: Synthesis of a new class of putative muscle relaxant compounds. J Med Chem. 2006 Sep 7;49(18):5571-7. DMID7TC RU https://pubmed.ncbi.nlm.nih.gov/16942030 DMID7TC DI DMID7TC DMID7TC DN 3-demethoxy-3D-glucopyranosylaminothiocolchicine DMID7TC MI TTF45NW DMID7TC MN Strychnine-binding glycine receptor (GLRA1) DMID7TC MT DTT DMID7TC MA Inhibitor DMID7TC RN 3-demethoxy-3-glycosylaminothiocolchicines: Synthesis of a new class of putative muscle relaxant compounds. J Med Chem. 2006 Sep 7;49(18):5571-7. DMID7TC RU https://pubmed.ncbi.nlm.nih.gov/16942030 DME8VPC DI DME8VPC DME8VPC DN 3-demethoxy-3-D-lyxopyranosylaminothiocolchicine DME8VPC MI TT1MPAY DME8VPC MN GABA(A) receptor alpha-1 (GABRA1) DME8VPC MT DTT DME8VPC MA Inhibitor DME8VPC RN 3-demethoxy-3-glycosylaminothiocolchicines: Synthesis of a new class of putative muscle relaxant compounds. J Med Chem. 2006 Sep 7;49(18):5571-7. DME8VPC RU https://pubmed.ncbi.nlm.nih.gov/16942030 DME8VPC DI DME8VPC DME8VPC DN 3-demethoxy-3-D-lyxopyranosylaminothiocolchicine DME8VPC MI TTZA1NY DME8VPC MN GABA(A) receptor beta-2 (GABRB2) DME8VPC MT DTT DME8VPC MA Inhibitor DME8VPC RN 3-demethoxy-3-glycosylaminothiocolchicines: Synthesis of a new class of putative muscle relaxant compounds. J Med Chem. 2006 Sep 7;49(18):5571-7. DME8VPC RU https://pubmed.ncbi.nlm.nih.gov/16942030 DME8VPC DI DME8VPC DME8VPC DN 3-demethoxy-3-D-lyxopyranosylaminothiocolchicine DME8VPC MI TT06RH5 DME8VPC MN GABA(A) receptor gamma-2 (GABRG2) DME8VPC MT DTT DME8VPC MA Inhibitor DME8VPC RN 3-demethoxy-3-glycosylaminothiocolchicines: Synthesis of a new class of putative muscle relaxant compounds. J Med Chem. 2006 Sep 7;49(18):5571-7. DME8VPC RU https://pubmed.ncbi.nlm.nih.gov/16942030 DME8VPC DI DME8VPC DME8VPC DN 3-demethoxy-3-D-lyxopyranosylaminothiocolchicine DME8VPC MI TTNJYV2 DME8VPC MN Gamma-aminobutyric acid receptor (GAR) DME8VPC MT DTT DME8VPC MA Inhibitor DME8VPC RN 3-demethoxy-3-glycosylaminothiocolchicines: Synthesis of a new class of putative muscle relaxant compounds. J Med Chem. 2006 Sep 7;49(18):5571-7. DME8VPC RU https://pubmed.ncbi.nlm.nih.gov/16942030 DME8VPC DI DME8VPC DME8VPC DN 3-demethoxy-3-D-lyxopyranosylaminothiocolchicine DME8VPC MI TTZ8EM9 DME8VPC MN Glycine receptor (GlyR) DME8VPC MT DTT DME8VPC MA Inhibitor DME8VPC RN 3-demethoxy-3-glycosylaminothiocolchicines: Synthesis of a new class of putative muscle relaxant compounds. J Med Chem. 2006 Sep 7;49(18):5571-7. DME8VPC RU https://pubmed.ncbi.nlm.nih.gov/16942030 DME8VPC DI DME8VPC DME8VPC DN 3-demethoxy-3-D-lyxopyranosylaminothiocolchicine DME8VPC MI TTF45NW DME8VPC MN Strychnine-binding glycine receptor (GLRA1) DME8VPC MT DTT DME8VPC MA Inhibitor DME8VPC RN 3-demethoxy-3-glycosylaminothiocolchicines: Synthesis of a new class of putative muscle relaxant compounds. J Med Chem. 2006 Sep 7;49(18):5571-7. DME8VPC RU https://pubmed.ncbi.nlm.nih.gov/16942030 DMALMGH DI DMALMGH DMALMGH DN 3-demethoxy-3-D-mannopyranosylaminothiocolchicine DMALMGH MI TT1MPAY DMALMGH MN GABA(A) receptor alpha-1 (GABRA1) DMALMGH MT DTT DMALMGH MA Inhibitor DMALMGH RN 3-demethoxy-3-glycosylaminothiocolchicines: Synthesis of a new class of putative muscle relaxant compounds. J Med Chem. 2006 Sep 7;49(18):5571-7. DMALMGH RU https://pubmed.ncbi.nlm.nih.gov/16942030 DMALMGH DI DMALMGH DMALMGH DN 3-demethoxy-3-D-mannopyranosylaminothiocolchicine DMALMGH MI TTZA1NY DMALMGH MN GABA(A) receptor beta-2 (GABRB2) DMALMGH MT DTT DMALMGH MA Inhibitor DMALMGH RN 3-demethoxy-3-glycosylaminothiocolchicines: Synthesis of a new class of putative muscle relaxant compounds. J Med Chem. 2006 Sep 7;49(18):5571-7. DMALMGH RU https://pubmed.ncbi.nlm.nih.gov/16942030 DMALMGH DI DMALMGH DMALMGH DN 3-demethoxy-3-D-mannopyranosylaminothiocolchicine DMALMGH MI TT06RH5 DMALMGH MN GABA(A) receptor gamma-2 (GABRG2) DMALMGH MT DTT DMALMGH MA Inhibitor DMALMGH RN 3-demethoxy-3-glycosylaminothiocolchicines: Synthesis of a new class of putative muscle relaxant compounds. J Med Chem. 2006 Sep 7;49(18):5571-7. DMALMGH RU https://pubmed.ncbi.nlm.nih.gov/16942030 DMALMGH DI DMALMGH DMALMGH DN 3-demethoxy-3-D-mannopyranosylaminothiocolchicine DMALMGH MI TTNJYV2 DMALMGH MN Gamma-aminobutyric acid receptor (GAR) DMALMGH MT DTT DMALMGH MA Inhibitor DMALMGH RN 3-demethoxy-3-glycosylaminothiocolchicines: Synthesis of a new class of putative muscle relaxant compounds. J Med Chem. 2006 Sep 7;49(18):5571-7. DMALMGH RU https://pubmed.ncbi.nlm.nih.gov/16942030 DMALMGH DI DMALMGH DMALMGH DN 3-demethoxy-3-D-mannopyranosylaminothiocolchicine DMALMGH MI TTZ8EM9 DMALMGH MN Glycine receptor (GlyR) DMALMGH MT DTT DMALMGH MA Inhibitor DMALMGH RN 3-demethoxy-3-glycosylaminothiocolchicines: Synthesis of a new class of putative muscle relaxant compounds. J Med Chem. 2006 Sep 7;49(18):5571-7. DMALMGH RU https://pubmed.ncbi.nlm.nih.gov/16942030 DMALMGH DI DMALMGH DMALMGH DN 3-demethoxy-3-D-mannopyranosylaminothiocolchicine DMALMGH MI TTF45NW DMALMGH MN Strychnine-binding glycine receptor (GLRA1) DMALMGH MT DTT DMALMGH MA Inhibitor DMALMGH RN 3-demethoxy-3-glycosylaminothiocolchicines: Synthesis of a new class of putative muscle relaxant compounds. J Med Chem. 2006 Sep 7;49(18):5571-7. DMALMGH RU https://pubmed.ncbi.nlm.nih.gov/16942030 DMXFVD1 DI DMXFVD1 DMXFVD1 DN 3-demethoxy-3-D-xylopyranosylaminothiocolchicine DMXFVD1 MI TT1MPAY DMXFVD1 MN GABA(A) receptor alpha-1 (GABRA1) DMXFVD1 MT DTT DMXFVD1 MA Inhibitor DMXFVD1 RN 3-demethoxy-3-glycosylaminothiocolchicines: Synthesis of a new class of putative muscle relaxant compounds. J Med Chem. 2006 Sep 7;49(18):5571-7. DMXFVD1 RU https://pubmed.ncbi.nlm.nih.gov/16942030 DMXFVD1 DI DMXFVD1 DMXFVD1 DN 3-demethoxy-3-D-xylopyranosylaminothiocolchicine DMXFVD1 MI TTZA1NY DMXFVD1 MN GABA(A) receptor beta-2 (GABRB2) DMXFVD1 MT DTT DMXFVD1 MA Inhibitor DMXFVD1 RN 3-demethoxy-3-glycosylaminothiocolchicines: Synthesis of a new class of putative muscle relaxant compounds. J Med Chem. 2006 Sep 7;49(18):5571-7. DMXFVD1 RU https://pubmed.ncbi.nlm.nih.gov/16942030 DMXFVD1 DI DMXFVD1 DMXFVD1 DN 3-demethoxy-3-D-xylopyranosylaminothiocolchicine DMXFVD1 MI TT06RH5 DMXFVD1 MN GABA(A) receptor gamma-2 (GABRG2) DMXFVD1 MT DTT DMXFVD1 MA Inhibitor DMXFVD1 RN 3-demethoxy-3-glycosylaminothiocolchicines: Synthesis of a new class of putative muscle relaxant compounds. J Med Chem. 2006 Sep 7;49(18):5571-7. DMXFVD1 RU https://pubmed.ncbi.nlm.nih.gov/16942030 DMXFVD1 DI DMXFVD1 DMXFVD1 DN 3-demethoxy-3-D-xylopyranosylaminothiocolchicine DMXFVD1 MI TTNJYV2 DMXFVD1 MN Gamma-aminobutyric acid receptor (GAR) DMXFVD1 MT DTT DMXFVD1 MA Inhibitor DMXFVD1 RN 3-demethoxy-3-glycosylaminothiocolchicines: Synthesis of a new class of putative muscle relaxant compounds. J Med Chem. 2006 Sep 7;49(18):5571-7. DMXFVD1 RU https://pubmed.ncbi.nlm.nih.gov/16942030 DMXFVD1 DI DMXFVD1 DMXFVD1 DN 3-demethoxy-3-D-xylopyranosylaminothiocolchicine DMXFVD1 MI TTZ8EM9 DMXFVD1 MN Glycine receptor (GlyR) DMXFVD1 MT DTT DMXFVD1 MA Inhibitor DMXFVD1 RN 3-demethoxy-3-glycosylaminothiocolchicines: Synthesis of a new class of putative muscle relaxant compounds. J Med Chem. 2006 Sep 7;49(18):5571-7. DMXFVD1 RU https://pubmed.ncbi.nlm.nih.gov/16942030 DMXFVD1 DI DMXFVD1 DMXFVD1 DN 3-demethoxy-3-D-xylopyranosylaminothiocolchicine DMXFVD1 MI TTF45NW DMXFVD1 MN Strychnine-binding glycine receptor (GLRA1) DMXFVD1 MT DTT DMXFVD1 MA Inhibitor DMXFVD1 RN 3-demethoxy-3-glycosylaminothiocolchicines: Synthesis of a new class of putative muscle relaxant compounds. J Med Chem. 2006 Sep 7;49(18):5571-7. DMXFVD1 RU https://pubmed.ncbi.nlm.nih.gov/16942030 DM4ERYF DI DM4ERYF DM4ERYF DN 3-demethoxy-3-L-fucopyranosylaminothiocolchicine DM4ERYF MI TT1MPAY DM4ERYF MN GABA(A) receptor alpha-1 (GABRA1) DM4ERYF MT DTT DM4ERYF MA Inhibitor DM4ERYF RN 3-demethoxy-3-glycosylaminothiocolchicines: Synthesis of a new class of putative muscle relaxant compounds. J Med Chem. 2006 Sep 7;49(18):5571-7. DM4ERYF RU https://pubmed.ncbi.nlm.nih.gov/16942030 DM4ERYF DI DM4ERYF DM4ERYF DN 3-demethoxy-3-L-fucopyranosylaminothiocolchicine DM4ERYF MI TTZA1NY DM4ERYF MN GABA(A) receptor beta-2 (GABRB2) DM4ERYF MT DTT DM4ERYF MA Inhibitor DM4ERYF RN 3-demethoxy-3-glycosylaminothiocolchicines: Synthesis of a new class of putative muscle relaxant compounds. J Med Chem. 2006 Sep 7;49(18):5571-7. DM4ERYF RU https://pubmed.ncbi.nlm.nih.gov/16942030 DM4ERYF DI DM4ERYF DM4ERYF DN 3-demethoxy-3-L-fucopyranosylaminothiocolchicine DM4ERYF MI TT06RH5 DM4ERYF MN GABA(A) receptor gamma-2 (GABRG2) DM4ERYF MT DTT DM4ERYF MA Inhibitor DM4ERYF RN 3-demethoxy-3-glycosylaminothiocolchicines: Synthesis of a new class of putative muscle relaxant compounds. J Med Chem. 2006 Sep 7;49(18):5571-7. DM4ERYF RU https://pubmed.ncbi.nlm.nih.gov/16942030 DM4ERYF DI DM4ERYF DM4ERYF DN 3-demethoxy-3-L-fucopyranosylaminothiocolchicine DM4ERYF MI TTNJYV2 DM4ERYF MN Gamma-aminobutyric acid receptor (GAR) DM4ERYF MT DTT DM4ERYF MA Inhibitor DM4ERYF RN 3-demethoxy-3-glycosylaminothiocolchicines: Synthesis of a new class of putative muscle relaxant compounds. J Med Chem. 2006 Sep 7;49(18):5571-7. DM4ERYF RU https://pubmed.ncbi.nlm.nih.gov/16942030 DM4ERYF DI DM4ERYF DM4ERYF DN 3-demethoxy-3-L-fucopyranosylaminothiocolchicine DM4ERYF MI TTZ8EM9 DM4ERYF MN Glycine receptor (GlyR) DM4ERYF MT DTT DM4ERYF MA Inhibitor DM4ERYF RN 3-demethoxy-3-glycosylaminothiocolchicines: Synthesis of a new class of putative muscle relaxant compounds. J Med Chem. 2006 Sep 7;49(18):5571-7. DM4ERYF RU https://pubmed.ncbi.nlm.nih.gov/16942030 DM4ERYF DI DM4ERYF DM4ERYF DN 3-demethoxy-3-L-fucopyranosylaminothiocolchicine DM4ERYF MI TTF45NW DM4ERYF MN Strychnine-binding glycine receptor (GLRA1) DM4ERYF MT DTT DM4ERYF MA Inhibitor DM4ERYF RN 3-demethoxy-3-glycosylaminothiocolchicines: Synthesis of a new class of putative muscle relaxant compounds. J Med Chem. 2006 Sep 7;49(18):5571-7. DM4ERYF RU https://pubmed.ncbi.nlm.nih.gov/16942030 DMFQUGE DI DMFQUGE DMFQUGE DN 3-Deoxyguanosine DMFQUGE MI TTMCF1Y DMFQUGE MN Purine nucleoside phosphorylase (PNP) DMFQUGE MT DTT DMFQUGE MA Inhibitor DMFQUGE RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMFQUGE RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMBNA0V DI DMBNA0V DMBNA0V DN 3-desoxy-3-carboxamidonaltrexone DMBNA0V MI TT27RFC DMBNA0V MN Opioid receptor delta (OPRD1) DMBNA0V MT DTT DMBNA0V MA Inhibitor DMBNA0V RN Syntheses of novel high affinity ligands for opioid receptors. Bioorg Med Chem Lett. 2009 Apr 15;19(8):2289-94. DMBNA0V RU https://pubmed.ncbi.nlm.nih.gov/19282177 DMBNA0V DI DMBNA0V DMBNA0V DN 3-desoxy-3-carboxamidonaltrexone DMBNA0V MI TTQW87Y DMBNA0V MN Opioid receptor kappa (OPRK1) DMBNA0V MT DTT DMBNA0V MA Inhibitor DMBNA0V RN Syntheses of novel high affinity ligands for opioid receptors. Bioorg Med Chem Lett. 2009 Apr 15;19(8):2289-94. DMBNA0V RU https://pubmed.ncbi.nlm.nih.gov/19282177 DMBNA0V DI DMBNA0V DMBNA0V DN 3-desoxy-3-carboxamidonaltrexone DMBNA0V MI TTKWM86 DMBNA0V MN Opioid receptor mu (MOP) DMBNA0V MT DTT DMBNA0V MA Inhibitor DMBNA0V RN Syntheses of novel high affinity ligands for opioid receptors. Bioorg Med Chem Lett. 2009 Apr 15;19(8):2289-94. DMBNA0V RU https://pubmed.ncbi.nlm.nih.gov/19282177 DMSJUOH DI DMSJUOH DMSJUOH DN 3-Dimethylaminomethyl-1H-indol-4-ol DMSJUOH MI TTJQOD7 DMSJUOH MN 5-HT 2A receptor (HTR2A) DMSJUOH MT DTT DMSJUOH MA Inhibitor DMSJUOH RN SAR of psilocybin analogs: discovery of a selective 5-HT 2C agonist. Bioorg Med Chem Lett. 2005 Oct 15;15(20):4555-9. DMSJUOH RU https://pubmed.ncbi.nlm.nih.gov/16061378 DMSJUOH DI DMSJUOH DMSJUOH DN 3-Dimethylaminomethyl-1H-indol-4-ol DMSJUOH MI TT0K1SC DMSJUOH MN 5-HT 2B receptor (HTR2B) DMSJUOH MT DTT DMSJUOH MA Inhibitor DMSJUOH RN SAR of psilocybin analogs: discovery of a selective 5-HT 2C agonist. Bioorg Med Chem Lett. 2005 Oct 15;15(20):4555-9. DMSJUOH RU https://pubmed.ncbi.nlm.nih.gov/16061378 DMSJUOH DI DMSJUOH DMSJUOH DN 3-Dimethylaminomethyl-1H-indol-4-ol DMSJUOH MI TTWJBZ5 DMSJUOH MN 5-HT 2C receptor (HTR2C) DMSJUOH MT DTT DMSJUOH MA Inhibitor DMSJUOH RN SAR of psilocybin analogs: discovery of a selective 5-HT 2C agonist. Bioorg Med Chem Lett. 2005 Oct 15;15(20):4555-9. DMSJUOH RU https://pubmed.ncbi.nlm.nih.gov/16061378 DMDOIJM DI DMDOIJM DMDOIJM DN 3-Dimethylaminomethyl-1-methyl-1H-indol-4-ol DMDOIJM MI TTJQOD7 DMDOIJM MN 5-HT 2A receptor (HTR2A) DMDOIJM MT DTT DMDOIJM MA Inhibitor DMDOIJM RN SAR of psilocybin analogs: discovery of a selective 5-HT 2C agonist. Bioorg Med Chem Lett. 2005 Oct 15;15(20):4555-9. DMDOIJM RU https://pubmed.ncbi.nlm.nih.gov/16061378 DMDOIJM DI DMDOIJM DMDOIJM DN 3-Dimethylaminomethyl-1-methyl-1H-indol-4-ol DMDOIJM MI TT0K1SC DMDOIJM MN 5-HT 2B receptor (HTR2B) DMDOIJM MT DTT DMDOIJM MA Inhibitor DMDOIJM RN SAR of psilocybin analogs: discovery of a selective 5-HT 2C agonist. Bioorg Med Chem Lett. 2005 Oct 15;15(20):4555-9. DMDOIJM RU https://pubmed.ncbi.nlm.nih.gov/16061378 DMDOIJM DI DMDOIJM DMDOIJM DN 3-Dimethylaminomethyl-1-methyl-1H-indol-4-ol DMDOIJM MI TTWJBZ5 DMDOIJM MN 5-HT 2C receptor (HTR2C) DMDOIJM MT DTT DMDOIJM MA Inhibitor DMDOIJM RN SAR of psilocybin analogs: discovery of a selective 5-HT 2C agonist. Bioorg Med Chem Lett. 2005 Oct 15;15(20):4555-9. DMDOIJM RU https://pubmed.ncbi.nlm.nih.gov/16061378 DMVHQB8 DI DMVHQB8 DMVHQB8 DN 3-DIPHENOL-6-NITRO-3H-BENZO[DE]ISOCHROMEN-1-ONE DMVHQB8 MI TTU6BFZ DMVHQB8 MN Candida Thymidylate synthase (Candi TMP1) DMVHQB8 MT DTT DMVHQB8 MA Inhibitor DMVHQB8 RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DMVHQB8 RU https://pubmed.ncbi.nlm.nih.gov/10592235 DMO5EBI DI DMO5EBI DMO5EBI DN 3-dodecyl-1,1-dimethylthiourea DMO5EBI MI TTAS2UO DMO5EBI MN Bacterial Urease (Bact ureC) DMO5EBI MT DTT DMO5EBI MA Inhibitor DMO5EBI RN Facile one-pot synthesis of thio and selenourea derivatives: a new class of potent urease inhibitors. Bioorg Med Chem Lett. 2007 Nov 15;17(22):6387-91. DMO5EBI RU https://pubmed.ncbi.nlm.nih.gov/17889535 DMQ8VIU DI DMQ8VIU DMQ8VIU DN 3-epicorosolic acid methyl ester DMQ8VIU MI TTN7BL9 DMQ8VIU MN Corticosteroid 11-beta-dehydrogenase 1 (HSD11B1) DMQ8VIU MT DTT DMQ8VIU MA Inhibitor DMQ8VIU RN 11beta-Hydroxysteroid dehydrogenase 1 inhibiting constituents from Eriobotrya japonica revealed by bioactivity-guided isolation and computational a... Bioorg Med Chem. 2010 Feb 15;18(4):1507-15. DMQ8VIU RU https://pubmed.ncbi.nlm.nih.gov/20100662 DM1UOWB DI DM1UOWB DM1UOWB DN 3-epi-masilinic acid DM1UOWB MI TTELIN2 DM1UOWB MN PTPN1 messenger RNA (PTPN1 mRNA) DM1UOWB MT DTT DM1UOWB MA Inhibitor DM1UOWB RN Synthesis and biological evaluation of heterocyclic ring-substituted maslinic acid derivatives as novel inhibitors of protein tyrosine phosphatase 1B. Bioorg Med Chem Lett. 2009 Dec 1;19(23):6618-22. DM1UOWB RU https://pubmed.ncbi.nlm.nih.gov/19846303 DMTKQNU DI DMTKQNU DMTKQNU DN 3-Ethenylquinoline-8-carboxamide DMTKQNU MI TTVDSZ0 DMTKQNU MN Poly [ADP-ribose] polymerase 1 (PARP1) DMTKQNU MT DTT DMTKQNU MA Inhibitor DMTKQNU RN Design, synthesis, and evaluation in vitro of quinoline-8-carboxamides, a new class of poly(adenosine-diphosphate-ribose)polymerase-1 (PARP-1) inhi... J Med Chem. 2009 Feb 12;52(3):868-77. DMTKQNU RU https://pubmed.ncbi.nlm.nih.gov/19117416 DMSK6EM DI DMSK6EM DMSK6EM DN 3-ethoxy-5-(2-methylquinolin-7-yl)benzonitrile DMSK6EM MI TTHS256 DMSK6EM MN Metabotropic glutamate receptor 5 (mGluR5) DMSK6EM MT DTT DMSK6EM MA Inhibitor DMSK6EM RN Rational design of 7-arylquinolines as non-competitive metabotropic glutamate receptor subtype 5 antagonists. Bioorg Med Chem Lett. 2007 Aug 15;17(16):4415-8. DMSK6EM RU https://pubmed.ncbi.nlm.nih.gov/17590335 DMWZDA1 DI DMWZDA1 DMWZDA1 DN 3-Ethoxy-5-(6-methoxynaphthalen-2-yl)pyridine DMWZDA1 MI TTIQUX7 DMWZDA1 MN Steroid 11-beta-hydroxylase (CYP11B1) DMWZDA1 MT DTT DMWZDA1 MA Inhibitor DMWZDA1 RN Overcoming undesirable CYP1A2 inhibition of pyridylnaphthalene-type aldosterone synthase inhibitors: influence of heteroaryl derivatization on pote... J Med Chem. 2008 Aug 28;51(16):5064-74. DMWZDA1 RU https://pubmed.ncbi.nlm.nih.gov/18672861 DM6K7BI DI DM6K7BI DM6K7BI DN 3-Ethoxy-9H-beta-carboline DM6K7BI MI TT1MPAY DM6K7BI MN GABA(A) receptor alpha-1 (GABRA1) DM6K7BI MT DTT DM6K7BI MA Inhibitor DM6K7BI RN Synthesis of novel 3-substituted beta-carbolines as benzodiazepine receptor ligands: probing the benzodiazepine receptor pharmacophore. J Med Chem. 1988 Sep;31(9):1854-61. DM6K7BI RU https://pubmed.ncbi.nlm.nih.gov/2842507 DM6K7BI DI DM6K7BI DM6K7BI DN 3-Ethoxy-9H-beta-carboline DM6K7BI MI TTBMV1G DM6K7BI MN GABA(A) receptor alpha-2 (GABRA2) DM6K7BI MT DTT DM6K7BI MA Inhibitor DM6K7BI RN Synthesis and evaluation of analogues of the partial agonist 6-(propyloxy)-4-(methoxymethyl)-beta-carboline-3-carboxylic acid ethyl ester (6-PBC) a... J Med Chem. 1998 Jul 2;41(14):2537-52. DM6K7BI RU https://pubmed.ncbi.nlm.nih.gov/9651158 DM6K7BI DI DM6K7BI DM6K7BI DN 3-Ethoxy-9H-beta-carboline DM6K7BI MI TT37EDJ DM6K7BI MN GABA(A) receptor alpha-3 (GABRA3) DM6K7BI MT DTT DM6K7BI MA Inhibitor DM6K7BI RN Design, synthesis, and subtype selectivity of 3,6-disubstituted -carbolines at Bz/GABA(A)ergic receptors. SAR and studies directed toward agents f... Bioorg Med Chem. 2010 Nov 1;18(21):7548-64. DM6K7BI RU https://pubmed.ncbi.nlm.nih.gov/20888240 DM6K7BI DI DM6K7BI DM6K7BI DN 3-Ethoxy-9H-beta-carboline DM6K7BI MI TTNZPQ1 DM6K7BI MN GABA(A) receptor alpha-5 (GABRA5) DM6K7BI MT DTT DM6K7BI MA Inhibitor DM6K7BI RN Design, synthesis, and subtype selectivity of 3,6-disubstituted -carbolines at Bz/GABA(A)ergic receptors. SAR and studies directed toward agents f... Bioorg Med Chem. 2010 Nov 1;18(21):7548-64. DM6K7BI RU https://pubmed.ncbi.nlm.nih.gov/20888240 DM6K7BI DI DM6K7BI DM6K7BI DN 3-Ethoxy-9H-beta-carboline DM6K7BI MI TT06RH5 DM6K7BI MN GABA(A) receptor gamma-2 (GABRG2) DM6K7BI MT DTT DM6K7BI MA Inhibitor DM6K7BI RN Synthesis and evaluation of analogues of the partial agonist 6-(propyloxy)-4-(methoxymethyl)-beta-carboline-3-carboxylic acid ethyl ester (6-PBC) a... J Med Chem. 1998 Jul 2;41(14):2537-52. DM6K7BI RU https://pubmed.ncbi.nlm.nih.gov/9651158 DM6K7BI DI DM6K7BI DM6K7BI DN 3-Ethoxy-9H-beta-carboline DM6K7BI MI TTNJYV2 DM6K7BI MN Gamma-aminobutyric acid receptor (GAR) DM6K7BI MT DTT DM6K7BI MA Inhibitor DM6K7BI RN Synthesis and evaluation of analogues of the partial agonist 6-(propyloxy)-4-(methoxymethyl)-beta-carboline-3-carboxylic acid ethyl ester (6-PBC) a... J Med Chem. 1998 Jul 2;41(14):2537-52. DM6K7BI RU https://pubmed.ncbi.nlm.nih.gov/9651158 DMY4VOI DI DMY4VOI DMY4VOI DN 3-ethoxycarbonyl-4-quinolone DMY4VOI MI TT1MPAY DMY4VOI MN GABA(A) receptor alpha-1 (GABRA1) DMY4VOI MT DTT DMY4VOI MA Inhibitor DMY4VOI RN 4-quinolone derivatives: high-affinity ligands at the benzodiazepine site of brain GABA A receptors. synthesis, pharmacology, and pharmacophore mod... J Med Chem. 2006 Apr 20;49(8):2526-33. DMY4VOI RU https://pubmed.ncbi.nlm.nih.gov/16610795 DMY4VOI DI DMY4VOI DMY4VOI DN 3-ethoxycarbonyl-4-quinolone DMY4VOI MI TTZA1NY DMY4VOI MN GABA(A) receptor beta-2 (GABRB2) DMY4VOI MT DTT DMY4VOI MA Inhibitor DMY4VOI RN 4-quinolone derivatives: high-affinity ligands at the benzodiazepine site of brain GABA A receptors. synthesis, pharmacology, and pharmacophore mod... J Med Chem. 2006 Apr 20;49(8):2526-33. DMY4VOI RU https://pubmed.ncbi.nlm.nih.gov/16610795 DMY4VOI DI DMY4VOI DMY4VOI DN 3-ethoxycarbonyl-4-quinolone DMY4VOI MI TT06RH5 DMY4VOI MN GABA(A) receptor gamma-2 (GABRG2) DMY4VOI MT DTT DMY4VOI MA Inhibitor DMY4VOI RN 4-quinolone derivatives: high-affinity ligands at the benzodiazepine site of brain GABA A receptors. synthesis, pharmacology, and pharmacophore mod... J Med Chem. 2006 Apr 20;49(8):2526-33. DMY4VOI RU https://pubmed.ncbi.nlm.nih.gov/16610795 DMY4VOI DI DMY4VOI DMY4VOI DN 3-ethoxycarbonyl-4-quinolone DMY4VOI MI TTNJYV2 DMY4VOI MN Gamma-aminobutyric acid receptor (GAR) DMY4VOI MT DTT DMY4VOI MA Inhibitor DMY4VOI RN 4-quinolone derivatives: high-affinity ligands at the benzodiazepine site of brain GABA A receptors. synthesis, pharmacology, and pharmacophore mod... J Med Chem. 2006 Apr 20;49(8):2526-33. DMY4VOI RU https://pubmed.ncbi.nlm.nih.gov/16610795 DMMDOI4 DI DMMDOI4 DMMDOI4 DN 3-ethoxycarbonyl-6-ethyl-2-methyl-4-quinolone DMMDOI4 MI TT1MPAY DMMDOI4 MN GABA(A) receptor alpha-1 (GABRA1) DMMDOI4 MT DTT DMMDOI4 MA Inhibitor DMMDOI4 RN 4-quinolone derivatives: high-affinity ligands at the benzodiazepine site of brain GABA A receptors. synthesis, pharmacology, and pharmacophore mod... J Med Chem. 2006 Apr 20;49(8):2526-33. DMMDOI4 RU https://pubmed.ncbi.nlm.nih.gov/16610795 DMMDOI4 DI DMMDOI4 DMMDOI4 DN 3-ethoxycarbonyl-6-ethyl-2-methyl-4-quinolone DMMDOI4 MI TTZA1NY DMMDOI4 MN GABA(A) receptor beta-2 (GABRB2) DMMDOI4 MT DTT DMMDOI4 MA Inhibitor DMMDOI4 RN 4-quinolone derivatives: high-affinity ligands at the benzodiazepine site of brain GABA A receptors. synthesis, pharmacology, and pharmacophore mod... J Med Chem. 2006 Apr 20;49(8):2526-33. DMMDOI4 RU https://pubmed.ncbi.nlm.nih.gov/16610795 DMMDOI4 DI DMMDOI4 DMMDOI4 DN 3-ethoxycarbonyl-6-ethyl-2-methyl-4-quinolone DMMDOI4 MI TT06RH5 DMMDOI4 MN GABA(A) receptor gamma-2 (GABRG2) DMMDOI4 MT DTT DMMDOI4 MA Inhibitor DMMDOI4 RN 4-quinolone derivatives: high-affinity ligands at the benzodiazepine site of brain GABA A receptors. synthesis, pharmacology, and pharmacophore mod... J Med Chem. 2006 Apr 20;49(8):2526-33. DMMDOI4 RU https://pubmed.ncbi.nlm.nih.gov/16610795 DMMDOI4 DI DMMDOI4 DMMDOI4 DN 3-ethoxycarbonyl-6-ethyl-2-methyl-4-quinolone DMMDOI4 MI TTNJYV2 DMMDOI4 MN Gamma-aminobutyric acid receptor (GAR) DMMDOI4 MT DTT DMMDOI4 MA Inhibitor DMMDOI4 RN 4-quinolone derivatives: high-affinity ligands at the benzodiazepine site of brain GABA A receptors. synthesis, pharmacology, and pharmacophore mod... J Med Chem. 2006 Apr 20;49(8):2526-33. DMMDOI4 RU https://pubmed.ncbi.nlm.nih.gov/16610795 DM1E5QZ DI DM1E5QZ DM1E5QZ DN 3-ethoxycarbonyl-6-propyl-4-quinolone DM1E5QZ MI TT1MPAY DM1E5QZ MN GABA(A) receptor alpha-1 (GABRA1) DM1E5QZ MT DTT DM1E5QZ MA Inhibitor DM1E5QZ RN 4-quinolone derivatives: high-affinity ligands at the benzodiazepine site of brain GABA A receptors. synthesis, pharmacology, and pharmacophore mod... J Med Chem. 2006 Apr 20;49(8):2526-33. DM1E5QZ RU https://pubmed.ncbi.nlm.nih.gov/16610795 DM1E5QZ DI DM1E5QZ DM1E5QZ DN 3-ethoxycarbonyl-6-propyl-4-quinolone DM1E5QZ MI TTZA1NY DM1E5QZ MN GABA(A) receptor beta-2 (GABRB2) DM1E5QZ MT DTT DM1E5QZ MA Inhibitor DM1E5QZ RN 4-quinolone derivatives: high-affinity ligands at the benzodiazepine site of brain GABA A receptors. synthesis, pharmacology, and pharmacophore mod... J Med Chem. 2006 Apr 20;49(8):2526-33. DM1E5QZ RU https://pubmed.ncbi.nlm.nih.gov/16610795 DM1E5QZ DI DM1E5QZ DM1E5QZ DN 3-ethoxycarbonyl-6-propyl-4-quinolone DM1E5QZ MI TT06RH5 DM1E5QZ MN GABA(A) receptor gamma-2 (GABRG2) DM1E5QZ MT DTT DM1E5QZ MA Inhibitor DM1E5QZ RN 4-quinolone derivatives: high-affinity ligands at the benzodiazepine site of brain GABA A receptors. synthesis, pharmacology, and pharmacophore mod... J Med Chem. 2006 Apr 20;49(8):2526-33. DM1E5QZ RU https://pubmed.ncbi.nlm.nih.gov/16610795 DM1E5QZ DI DM1E5QZ DM1E5QZ DN 3-ethoxycarbonyl-6-propyl-4-quinolone DM1E5QZ MI TTNJYV2 DM1E5QZ MN Gamma-aminobutyric acid receptor (GAR) DM1E5QZ MT DTT DM1E5QZ MA Inhibitor DM1E5QZ RN 4-quinolone derivatives: high-affinity ligands at the benzodiazepine site of brain GABA A receptors. synthesis, pharmacology, and pharmacophore mod... J Med Chem. 2006 Apr 20;49(8):2526-33. DM1E5QZ RU https://pubmed.ncbi.nlm.nih.gov/16610795 DM4YL5Q DI DM4YL5Q DM4YL5Q DN 3-ethoxycarbonylpyroglutamate DM4YL5Q MI TTHI19T DM4YL5Q MN Staphylococcus Beta-lactamase (Stap-coc blaZ) DM4YL5Q MT DTT DM4YL5Q MA Inhibitor DM4YL5Q RN Discovery of novel lipophilic inhibitors of OXA-10 enzyme (class D beta-lactamase) by screening amino analogs and homologs of citrate and isocitrate. Bioorg Med Chem Lett. 2009 Jul 1;19(13):3593-7. DM4YL5Q RU https://pubmed.ncbi.nlm.nih.gov/19467869 DMX2JKQ DI DMX2JKQ DMX2JKQ DN 3-Ethyl-[1,4]thiazepan-(5E)-ylideneamine DMX2JKQ MI TTZUFI5 DMX2JKQ MN Nitric-oxide synthase brain (NOS1) DMX2JKQ MT DTT DMX2JKQ MA Inhibitor DMX2JKQ RN Synthesis of analogs of (1,4)-3- and 5-imino oxazepane, thiazepane, and diazepane as inhibitors of nitric oxide synthases. Bioorg Med Chem Lett. 2004 Dec 6;14(23):5907-11. DMX2JKQ RU https://pubmed.ncbi.nlm.nih.gov/15501067 DMX2JKQ DI DMX2JKQ DMX2JKQ DN 3-Ethyl-[1,4]thiazepan-(5E)-ylideneamine DMX2JKQ MI TTCM4B3 DMX2JKQ MN Nitric-oxide synthase endothelial (NOS3) DMX2JKQ MT DTT DMX2JKQ MA Inhibitor DMX2JKQ RN Synthesis of analogs of (1,4)-3- and 5-imino oxazepane, thiazepane, and diazepane as inhibitors of nitric oxide synthases. Bioorg Med Chem Lett. 2004 Dec 6;14(23):5907-11. DMX2JKQ RU https://pubmed.ncbi.nlm.nih.gov/15501067 DMX2JKQ DI DMX2JKQ DMX2JKQ DN 3-Ethyl-[1,4]thiazepan-(5E)-ylideneamine DMX2JKQ MI TTF10I9 DMX2JKQ MN Nitric-oxide synthase inducible (NOS2) DMX2JKQ MT DTT DMX2JKQ MA Inhibitor DMX2JKQ RN Synthesis of analogs of (1,4)-3- and 5-imino oxazepane, thiazepane, and diazepane as inhibitors of nitric oxide synthases. Bioorg Med Chem Lett. 2004 Dec 6;14(23):5907-11. DMX2JKQ RU https://pubmed.ncbi.nlm.nih.gov/15501067 DMEWAVM DI DMEWAVM DMEWAVM DN 3-ETHYL-2-(4-HYDROXYPHENYL)-2H-INDAZOL-5-OL DMEWAVM MI TTZAYWL DMEWAVM MN Estrogen receptor (ESR) DMEWAVM MT DTT DMEWAVM MA Inhibitor DMEWAVM RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DMEWAVM RU https://pubmed.ncbi.nlm.nih.gov/10592235 DMN8C93 DI DMN8C93 DMN8C93 DN 3-Ethyl-2,3,4,5-tetrahydro-1H-benzo[d]azepin-6-ol DMN8C93 MI TTSQIFT DMN8C93 MN 5-HT 1A receptor (HTR1A) DMN8C93 MT DTT DMN8C93 MA Inhibitor DMN8C93 RN 6-Hydroxy-3-n-propyl-2,3,4,5-tetrahydro-1H-3-benzazepine and analogs: new centrally acting 5-HT1A receptor agonists. J Med Chem. 1992 Oct 30;35(22):3984-90. DMN8C93 RU https://pubmed.ncbi.nlm.nih.gov/1433207 DMN8C93 DI DMN8C93 DMN8C93 DN 3-Ethyl-2,3,4,5-tetrahydro-1H-benzo[d]azepin-6-ol DMN8C93 MI TTEX248 DMN8C93 MN Dopamine D2 receptor (D2R) DMN8C93 MT DTT DMN8C93 MA Inhibitor DMN8C93 RN 6-Hydroxy-3-n-propyl-2,3,4,5-tetrahydro-1H-3-benzazepine and analogs: new centrally acting 5-HT1A receptor agonists. J Med Chem. 1992 Oct 30;35(22):3984-90. DMN8C93 RU https://pubmed.ncbi.nlm.nih.gov/1433207 DMB8Q7T DI DMB8Q7T DMB8Q7T DN 3-Ethyl-3-isobutyl-1-phenylazetidine-2,4-dione DMB8Q7T MI TTPLTSQ DMB8Q7T MN Neutrophil elastase (NE) DMB8Q7T MT DTT DMB8Q7T MA Inhibitor DMB8Q7T RN 4-Oxo-beta-lactams (azetidine-2,4-diones) are potent and selective inhibitors of human leukocyte elastase. J Med Chem. 2010 Jan 14;53(1):241-53. DMB8Q7T RU https://pubmed.ncbi.nlm.nih.gov/19904934 DMZK13I DI DMZK13I DMZK13I DN 3-Ethyl-3-isopropyl-dihydro-furan-2-one DMZK13I MI TT1MPAY DMZK13I MN GABA(A) receptor alpha-1 (GABRA1) DMZK13I MT DTT DMZK13I MA Inhibitor DMZK13I RN Alpha-spirocyclopentyl- and alpha-spirocyclopropyl-gamma-butyrolactones: conformationally constrained derivatives of anticonvulsant and convulsant ... J Med Chem. 1994 Jan 21;37(2):275-86. DMZK13I RU https://pubmed.ncbi.nlm.nih.gov/8295215 DMZK13I DI DMZK13I DMZK13I DN 3-Ethyl-3-isopropyl-dihydro-furan-2-one DMZK13I MI TTZA1NY DMZK13I MN GABA(A) receptor beta-2 (GABRB2) DMZK13I MT DTT DMZK13I MA Inhibitor DMZK13I RN Alpha-spirocyclopentyl- and alpha-spirocyclopropyl-gamma-butyrolactones: conformationally constrained derivatives of anticonvulsant and convulsant ... J Med Chem. 1994 Jan 21;37(2):275-86. DMZK13I RU https://pubmed.ncbi.nlm.nih.gov/8295215 DMZK13I DI DMZK13I DMZK13I DN 3-Ethyl-3-isopropyl-dihydro-furan-2-one DMZK13I MI TT06RH5 DMZK13I MN GABA(A) receptor gamma-2 (GABRG2) DMZK13I MT DTT DMZK13I MA Inhibitor DMZK13I RN Alpha-spirocyclopentyl- and alpha-spirocyclopropyl-gamma-butyrolactones: conformationally constrained derivatives of anticonvulsant and convulsant ... J Med Chem. 1994 Jan 21;37(2):275-86. DMZK13I RU https://pubmed.ncbi.nlm.nih.gov/8295215 DMZK13I DI DMZK13I DMZK13I DN 3-Ethyl-3-isopropyl-dihydro-furan-2-one DMZK13I MI TTNJYV2 DMZK13I MN Gamma-aminobutyric acid receptor (GAR) DMZK13I MT DTT DMZK13I MA Inhibitor DMZK13I RN Alpha-spirocyclopentyl- and alpha-spirocyclopropyl-gamma-butyrolactones: conformationally constrained derivatives of anticonvulsant and convulsant ... J Med Chem. 1994 Jan 21;37(2):275-86. DMZK13I RU https://pubmed.ncbi.nlm.nih.gov/8295215 DM1VTFU DI DM1VTFU DM1VTFU DN 3-Ethyl-3-methyl-dihydro-furan-2-one DM1VTFU MI TT1MPAY DM1VTFU MN GABA(A) receptor alpha-1 (GABRA1) DM1VTFU MT DTT DM1VTFU MA Inhibitor DM1VTFU RN Alpha-spirocyclopentyl- and alpha-spirocyclopropyl-gamma-butyrolactones: conformationally constrained derivatives of anticonvulsant and convulsant ... J Med Chem. 1994 Jan 21;37(2):275-86. DM1VTFU RU https://pubmed.ncbi.nlm.nih.gov/8295215 DM1VTFU DI DM1VTFU DM1VTFU DN 3-Ethyl-3-methyl-dihydro-furan-2-one DM1VTFU MI TTZA1NY DM1VTFU MN GABA(A) receptor beta-2 (GABRB2) DM1VTFU MT DTT DM1VTFU MA Inhibitor DM1VTFU RN Alpha-spirocyclopentyl- and alpha-spirocyclopropyl-gamma-butyrolactones: conformationally constrained derivatives of anticonvulsant and convulsant ... J Med Chem. 1994 Jan 21;37(2):275-86. DM1VTFU RU https://pubmed.ncbi.nlm.nih.gov/8295215 DM1VTFU DI DM1VTFU DM1VTFU DN 3-Ethyl-3-methyl-dihydro-furan-2-one DM1VTFU MI TT06RH5 DM1VTFU MN GABA(A) receptor gamma-2 (GABRG2) DM1VTFU MT DTT DM1VTFU MA Inhibitor DM1VTFU RN Alpha-spirocyclopentyl- and alpha-spirocyclopropyl-gamma-butyrolactones: conformationally constrained derivatives of anticonvulsant and convulsant ... J Med Chem. 1994 Jan 21;37(2):275-86. DM1VTFU RU https://pubmed.ncbi.nlm.nih.gov/8295215 DM1VTFU DI DM1VTFU DM1VTFU DN 3-Ethyl-3-methyl-dihydro-furan-2-one DM1VTFU MI TTNJYV2 DM1VTFU MN Gamma-aminobutyric acid receptor (GAR) DM1VTFU MT DTT DM1VTFU MA Inhibitor DM1VTFU RN Alpha-spirocyclopentyl- and alpha-spirocyclopropyl-gamma-butyrolactones: conformationally constrained derivatives of anticonvulsant and convulsant ... J Med Chem. 1994 Jan 21;37(2):275-86. DM1VTFU RU https://pubmed.ncbi.nlm.nih.gov/8295215 DMGPRBE DI DMGPRBE DMGPRBE DN 3-Ethylquinoline-8-carboxamide DMGPRBE MI TTVDSZ0 DMGPRBE MN Poly [ADP-ribose] polymerase 1 (PARP1) DMGPRBE MT DTT DMGPRBE MA Inhibitor DMGPRBE RN Design, synthesis, and evaluation in vitro of quinoline-8-carboxamides, a new class of poly(adenosine-diphosphate-ribose)polymerase-1 (PARP-1) inhi... J Med Chem. 2009 Feb 12;52(3):868-77. DMGPRBE RU https://pubmed.ncbi.nlm.nih.gov/19117416 DMS4JGT DI DMS4JGT DMS4JGT DN 3-Ethynylquinoline-8-carboxamide DMS4JGT MI TTVDSZ0 DMS4JGT MN Poly [ADP-ribose] polymerase 1 (PARP1) DMS4JGT MT DTT DMS4JGT MA Inhibitor DMS4JGT RN Design, synthesis, and evaluation in vitro of quinoline-8-carboxamides, a new class of poly(adenosine-diphosphate-ribose)polymerase-1 (PARP-1) inhi... J Med Chem. 2009 Feb 12;52(3):868-77. DMS4JGT RU https://pubmed.ncbi.nlm.nih.gov/19117416 DMR29IQ DI DMR29IQ DMR29IQ DN 3-Fluoren-9-ylidenemethyl-pyridine DMR29IQ MI TTSZLWK DMR29IQ MN Aromatase (CYP19A1) DMR29IQ MT DTT DMR29IQ MA Inhibitor DMR29IQ RN Synthesis and evaluation of (pyridylmethylene)tetrahydronaphthalenes/-indanes and structurally modified derivatives: potent and selective inhibitor... J Med Chem. 2005 Mar 10;48(5):1563-75. DMR29IQ RU https://pubmed.ncbi.nlm.nih.gov/15743198 DMTY92S DI DMTY92S DMTY92S DN 3-Fluoro-2-(Phosphonooxy)Propanoic Acid DMTY92S MI TTVNA43 DMTY92S MN Bacterial Deoxy-D-manno-octulosonate 8-phosphate synthase (Bact kdsA) DMTY92S MT DTT DMTY92S MA Inhibitor DMTY92S RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMTY92S RU https://pubmed.ncbi.nlm.nih.gov/17139284 DM4PLSU DI DM4PLSU DM4PLSU DN 3-fluoro-4'-(1-(pyridin-4-yl)propyl)biphenyl-4-ol DM4PLSU MI TTRA5BZ DM4PLSU MN Steroid 17-alpha-monooxygenase (S17AH) DM4PLSU MT DTT DM4PLSU MA Inhibitor DM4PLSU RN Isopropylidene substitution increases activity and selectivity of biphenylmethylene 4-pyridine type CYP17 inhibitors. J Med Chem. 2010 Jul 8;53(13):5049-53. DM4PLSU RU https://pubmed.ncbi.nlm.nih.gov/20550118 DMJ3WNP DI DMJ3WNP DMJ3WNP DN 3-Fluoro-4'-(pyridin-4-ylmethyl)biphenyl-4-ol DMJ3WNP MI TTSZLWK DMJ3WNP MN Aromatase (CYP19A1) DMJ3WNP MT DTT DMJ3WNP MA Inhibitor DMJ3WNP RN Replacement of imidazolyl by pyridyl in biphenylmethylenes results in selective CYP17 and dual CYP17/CYP11B1 inhibitors for the treatment of prosta... J Med Chem. 2010 Aug 12;53(15):5749-58. DMJ3WNP RU https://pubmed.ncbi.nlm.nih.gov/20684610 DMJ3WNP DI DMJ3WNP DMJ3WNP DN 3-Fluoro-4'-(pyridin-4-ylmethyl)biphenyl-4-ol DMJ3WNP MI TTIQUX7 DMJ3WNP MN Steroid 11-beta-hydroxylase (CYP11B1) DMJ3WNP MT DTT DMJ3WNP MA Inhibitor DMJ3WNP RN Replacement of imidazolyl by pyridyl in biphenylmethylenes results in selective CYP17 and dual CYP17/CYP11B1 inhibitors for the treatment of prosta... J Med Chem. 2010 Aug 12;53(15):5749-58. DMJ3WNP RU https://pubmed.ncbi.nlm.nih.gov/20684610 DMJ3WNP DI DMJ3WNP DMJ3WNP DN 3-Fluoro-4'-(pyridin-4-ylmethyl)biphenyl-4-ol DMJ3WNP MI TTRA5BZ DMJ3WNP MN Steroid 17-alpha-monooxygenase (S17AH) DMJ3WNP MT DTT DMJ3WNP MA Inhibitor DMJ3WNP RN Replacement of imidazolyl by pyridyl in biphenylmethylenes results in selective CYP17 and dual CYP17/CYP11B1 inhibitors for the treatment of prosta... J Med Chem. 2010 Aug 12;53(15):5749-58. DMJ3WNP RU https://pubmed.ncbi.nlm.nih.gov/20684610 DMLG69R DI DMLG69R DMLG69R DN 3-Fluoro-4-hydrazino-benzenesulfonamide DMLG69R MI TTHQPL7 DMLG69R MN Carbonic anhydrase I (CA-I) DMLG69R MT DTT DMLG69R MA Inhibitor DMLG69R RN Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/membrane-associated carbonic anhydrase isozymes I, II, and IX with sulfonamide... J Med Chem. 2005 Mar 24;48(6):2121-5. DMLG69R RU https://pubmed.ncbi.nlm.nih.gov/15771455 DMLG69R DI DMLG69R DMLG69R DN 3-Fluoro-4-hydrazino-benzenesulfonamide DMLG69R MI TTANPDJ DMLG69R MN Carbonic anhydrase II (CA-II) DMLG69R MT DTT DMLG69R MA Inhibitor DMLG69R RN Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/membrane-associated carbonic anhydrase isozymes I, II, and IX with sulfonamide... J Med Chem. 2005 Mar 24;48(6):2121-5. DMLG69R RU https://pubmed.ncbi.nlm.nih.gov/15771455 DMLG69R DI DMLG69R DMLG69R DN 3-Fluoro-4-hydrazino-benzenesulfonamide DMLG69R MI TT2LVK8 DMLG69R MN Carbonic anhydrase IX (CA-IX) DMLG69R MT DTT DMLG69R MA Inhibitor DMLG69R RN Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/membrane-associated carbonic anhydrase isozymes I, II, and IX with sulfonamide... J Med Chem. 2005 Mar 24;48(6):2121-5. DMLG69R RU https://pubmed.ncbi.nlm.nih.gov/15771455 DMH9VLF DI DMH9VLF DMH9VLF DN 3-fluoro-5-(1,6-naphthyridin-7-yl)benzonitrile DMH9VLF MI TTHS256 DMH9VLF MN Metabotropic glutamate receptor 5 (mGluR5) DMH9VLF MT DTT DMH9VLF MA Inhibitor DMH9VLF RN Synthesis and SAR comparison of regioisomeric aryl naphthyridines as potent mGlu5 receptor antagonists. Bioorg Med Chem Lett. 2007 Dec 1;17(23):6525-8. DMH9VLF RU https://pubmed.ncbi.nlm.nih.gov/17936624 DM2V45Z DI DM2V45Z DM2V45Z DN 3-fluoro-5-(2-methylquinolin-7-yl)benzonitrile DM2V45Z MI TTHS256 DM2V45Z MN Metabotropic glutamate receptor 5 (mGluR5) DM2V45Z MT DTT DM2V45Z MA Inhibitor DM2V45Z RN Rational design of 7-arylquinolines as non-competitive metabotropic glutamate receptor subtype 5 antagonists. Bioorg Med Chem Lett. 2007 Aug 15;17(16):4415-8. DM2V45Z RU https://pubmed.ncbi.nlm.nih.gov/17590335 DMDPY9N DI DMDPY9N DMDPY9N DN 3-Fluoro-5-[5-(4-hydroxyphenyl)-2-thienyl]phenol DMDPY9N MI TTIWB6L DMDPY9N MN Estradiol 17 beta-dehydrogenase 1 (17-beta-HSD1) DMDPY9N MT DTT DMDPY9N MA Inhibitor DMDPY9N RN New insights into the SAR and binding modes of bis(hydroxyphenyl)thiophenes and -benzenes: influence of additional substituents on 17beta-hydroxyst... J Med Chem. 2009 Nov 12;52(21):6724-43. DMDPY9N RU https://pubmed.ncbi.nlm.nih.gov/19831396 DMDPUC7 DI DMDPUC7 DMDPUC7 DN 3-Fluoromethyl-1,2,3,4-tetrahydro-isoquinoline DMDPUC7 MI TTWG9A4 DMDPUC7 MN Adrenergic receptor alpha-2A (ADRA2A) DMDPUC7 MT DTT DMDPUC7 MA Inhibitor DMDPUC7 RN 3-hydroxymethyl-7-(N-substituted aminosulfonyl)-1,2,3,4-tetrahydroisoquinoline inhibitors of phenylethanolamine N-methyltransferase that display re... J Med Chem. 2005 Jan 13;48(1):134-40. DMDPUC7 RU https://pubmed.ncbi.nlm.nih.gov/15634007 DMDPUC7 DI DMDPUC7 DMDPUC7 DN 3-Fluoromethyl-1,2,3,4-tetrahydro-isoquinoline DMDPUC7 MI TTWM4TY DMDPUC7 MN Adrenergic receptor alpha-2B (ADRA2B) DMDPUC7 MT DTT DMDPUC7 MA Inhibitor DMDPUC7 RN 3-hydroxymethyl-7-(N-substituted aminosulfonyl)-1,2,3,4-tetrahydroisoquinoline inhibitors of phenylethanolamine N-methyltransferase that display re... J Med Chem. 2005 Jan 13;48(1):134-40. DMDPUC7 RU https://pubmed.ncbi.nlm.nih.gov/15634007 DMDPUC7 DI DMDPUC7 DMDPUC7 DN 3-Fluoromethyl-1,2,3,4-tetrahydro-isoquinoline DMDPUC7 MI TT2NUT5 DMDPUC7 MN Adrenergic receptor alpha-2C (ADRA2C) DMDPUC7 MT DTT DMDPUC7 MA Inhibitor DMDPUC7 RN 3-hydroxymethyl-7-(N-substituted aminosulfonyl)-1,2,3,4-tetrahydroisoquinoline inhibitors of phenylethanolamine N-methyltransferase that display re... J Med Chem. 2005 Jan 13;48(1):134-40. DMDPUC7 RU https://pubmed.ncbi.nlm.nih.gov/15634007 DMECBLA DI DMECBLA DMECBLA DN 3-fluorovinylglycine DMECBLA MI TT6TMZU DMECBLA MN Mycobacterium Biosynthetic alanine racemase (MycB alr) DMECBLA MT DTT DMECBLA MA Inhibitor DMECBLA RN Mechanism-based inactivation of alanine racemase by 3-halovinylglycines. J Biol Chem. 1991 Nov 15;266(32):21657-65. DMECBLA RU https://pubmed.ncbi.nlm.nih.gov/1939194 DM8RY7G DI DM8RY7G DM8RY7G DN 3-formyl-4-phenyl-1,2,5-oxadiazole 2-oxide DM8RY7G MI TTR7UJ3 DM8RY7G MN Cytoplasmic thioredoxin reductase (TXNRD1) DM8RY7G MT DTT DM8RY7G MA Inhibitor DM8RY7G RN Structure mechanism insights and the role of nitric oxide donation guide the development of oxadiazole-2-oxides as therapeutic agents against schis... J Med Chem. 2009 Oct 22;52(20):6474-83. DM8RY7G RU https://pubmed.ncbi.nlm.nih.gov/19761212 DMBFCTZ DI DMBFCTZ DMBFCTZ DN 3h-Indole-5,6-Diol DMBFCTZ MI TTSZDQU DMBFCTZ MN Lactotransferrin (LTF) DMBFCTZ MT DTT DMBFCTZ MA Inhibitor DMBFCTZ RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMBFCTZ RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMLB2W5 DI DMLB2W5 DMLB2W5 DN 3h-Pyrazolo[4,3-D]Pyrimidin-7-Ol DMLB2W5 MI TTBL49X DMLB2W5 MN Plasmodium Hypoxanthine-guanine phosphoribosyltransferase (Malaria LACZ) DMLB2W5 MT DTT DMLB2W5 MA Inhibitor DMLB2W5 RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMLB2W5 RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMC70P1 DI DMC70P1 DMC70P1 DN 3-hydroxy capric acid DMC70P1 MI TTG0MQD DMC70P1 MN Inflammation-related GPCR EX33 (GPR84) DMC70P1 MT DTT DMC70P1 MA Agonist DMC70P1 RN Medium-chain fatty acid-sensing receptor, GPR84, is a proinflammatory receptor. J Biol Chem. 2013 Apr 12;288(15):10684-91. DMC70P1 RU https://pubmed.ncbi.nlm.nih.gov/23449982 DMZSOPU DI DMZSOPU DMZSOPU DN 3-Hydroxy-1H-benzo[b]azepine-2,5-dione DMZSOPU MI TTLD29N DMZSOPU MN Glutamate receptor ionotropic NMDA 1 (NMDAR1) DMZSOPU MT DTT DMZSOPU MA Inhibitor DMZSOPU RN Analogs of 3-hydroxy-1H-1-benzazepine-2,5-dione: structure-activity relationship at N-methyl-D-aspartate receptor glycine sites. J Med Chem. 1996 Nov 8;39(23):4643-53. DMZSOPU RU https://pubmed.ncbi.nlm.nih.gov/8917653 DMZSOPU DI DMZSOPU DMZSOPU DN 3-Hydroxy-1H-benzo[b]azepine-2,5-dione DMZSOPU MI TTKJEMQ DMZSOPU MN Glutamate receptor ionotropic NMDA 2A (NMDAR2A) DMZSOPU MT DTT DMZSOPU MA Inhibitor DMZSOPU RN Analogs of 3-hydroxy-1H-1-benzazepine-2,5-dione: structure-activity relationship at N-methyl-D-aspartate receptor glycine sites. J Med Chem. 1996 Nov 8;39(23):4643-53. DMZSOPU RU https://pubmed.ncbi.nlm.nih.gov/8917653 DMZSOPU DI DMZSOPU DMZSOPU DN 3-Hydroxy-1H-benzo[b]azepine-2,5-dione DMZSOPU MI TTN9D8E DMZSOPU MN Glutamate receptor ionotropic NMDA 2B (NMDAR2B) DMZSOPU MT DTT DMZSOPU MA Inhibitor DMZSOPU RN Analogs of 3-hydroxy-1H-1-benzazepine-2,5-dione: structure-activity relationship at N-methyl-D-aspartate receptor glycine sites. J Med Chem. 1996 Nov 8;39(23):4643-53. DMZSOPU RU https://pubmed.ncbi.nlm.nih.gov/8917653 DM4758S DI DM4758S DM4758S DN 3hydroxy-1-methyl-1-phenylurea DM4758S MI TTULVH8 DM4758S MN Tyrosinase (TYR) DM4758S MT DTT DM4758S MA Inhibitor DM4758S RN Analogues of N-hydroxy-N'-phenylthiourea and N-hydroxy-N'-phenylurea as inhibitors of tyrosinase and melanin formation. Bioorg Med Chem Lett. 2008 Jun 15;18(12):3607-10. DM4758S RU https://pubmed.ncbi.nlm.nih.gov/18501598 DMI785L DI DMI785L DMI785L DN 3-hydroxy-2-methoxybenzaldehyde DMI785L MI TTANPDJ DMI785L MN Carbonic anhydrase II (CA-II) DMI785L MT DTT DMI785L MA Inhibitor DMI785L RN Carbonic anhydrase inhibitors. Inhibition of human erythrocyte isozymes I and II with a series of antioxidant phenols. Bioorg Med Chem. 2009 Apr 15;17(8):3207-11. DMI785L RU https://pubmed.ncbi.nlm.nih.gov/19231207 DMIVDFW DI DMIVDFW DMIVDFW DN 3-hydroxy-2-phenylquinoline-4-carboxylic acid DMIVDFW MI TT3PQ2Y DMIVDFW MN Plasmodium Dihydroorotate dehydrogenase (Malaria DHOdehase) DMIVDFW MT DTT DMIVDFW MA Inhibitor DMIVDFW RN Synthesis and biological evaluation of quinoline salicylic acids as P-selectin antagonists. J Med Chem. 2007 Jan 11;50(1):21-39. DMIVDFW RU https://pubmed.ncbi.nlm.nih.gov/17201408 DMEK9DH DI DMEK9DH DMEK9DH DN 3-hydroxy-2-propionylcyclohex-2-enone DMEK9DH MI TT8DSFC DMEK9DH MN Hydroxyphenylpyruvate dioxygenase (HPD) DMEK9DH MT DTT DMEK9DH MA Inhibitor DMEK9DH RN Enzyme inhibition potency enhancement by active site metal chelating and hydrogen bonding induced conformation-restricted cyclopropanecarbonyl deri... Bioorg Med Chem Lett. 2006 Dec 1;16(23):6024-7. DMEK9DH RU https://pubmed.ncbi.nlm.nih.gov/16979340 DM3YO72 DI DM3YO72 DM3YO72 DN 3-hydroxy-3-methyl-6-phosphohexanoic acid DM3YO72 MI TTXMI0C DM3YO72 MN Phosphomevalonate kinase (PMVK) DM3YO72 MT DTT DM3YO72 MA Inhibitor DM3YO72 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 641). DM3YO72 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=641 DMJD0UV DI DMJD0UV DMJD0UV DN 3-Hydroxy-3-Methyl-Glutaric Acid DMJD0UV MI TTPADOQ DMJD0UV MN HMG-CoA reductase (HMGCR) DMJD0UV MT DTT DMJD0UV MA Inhibitor DMJD0UV RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMJD0UV RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMEJQTA DI DMEJQTA DMEJQTA DN 3-hydroxy-4,10-dimethyl-6H-benzo[c]chromen-6-one DMEJQTA MI TTOM3J0 DMEJQTA MN Estrogen receptor beta (ESR2) DMEJQTA MT DTT DMEJQTA MA Inhibitor DMEJQTA RN 6H-Benzo[c]chromen-6-one derivatives as selective ERbeta agonists. Bioorg Med Chem Lett. 2006 Mar 15;16(6):1468-72. DMEJQTA RU https://pubmed.ncbi.nlm.nih.gov/16412638 DMUME74 DI DMUME74 DMUME74 DN 3-hydroxy-4,7-dimethyl-6H-benzo[c]chromen-6-one DMUME74 MI TTOM3J0 DMUME74 MN Estrogen receptor beta (ESR2) DMUME74 MT DTT DMUME74 MA Inhibitor DMUME74 RN 6H-Benzo[c]chromen-6-one derivatives as selective ERbeta agonists. Bioorg Med Chem Lett. 2006 Mar 15;16(6):1468-72. DMUME74 RU https://pubmed.ncbi.nlm.nih.gov/16412638 DMDBJCY DI DMDBJCY DMDBJCY DN 3-hydroxy-4-methyl-6H-benzo[c]chromen-6-one DMDBJCY MI TTOM3J0 DMDBJCY MN Estrogen receptor beta (ESR2) DMDBJCY MT DTT DMDBJCY MA Inhibitor DMDBJCY RN 6H-Benzo[c]chromen-6-one derivatives as selective ERbeta agonists. Bioorg Med Chem Lett. 2006 Mar 15;16(6):1468-72. DMDBJCY RU https://pubmed.ncbi.nlm.nih.gov/16412638 DM5QZDL DI DM5QZDL DM5QZDL DN 3-Hydroxy-4-phenyl-5H-furan-2-one DM5QZDL MI TT8DSFC DM5QZDL MN Hydroxyphenylpyruvate dioxygenase (HPD) DM5QZDL MT DTT DM5QZDL MA Inhibitor DM5QZDL RN Design, synthesis, and evaluation of postulated transient intermediate and substrate analogues as inhibitors of 4-hydroxyphenylpyruvate dioxygenase. Bioorg Med Chem Lett. 2002 Jul 8;12(13):1709-13. DM5QZDL RU https://pubmed.ncbi.nlm.nih.gov/12067543 DMZS4P7 DI DMZS4P7 DMZS4P7 DN 3-hydroxy-5-(2-methylquinolin-7-yl)benzonitrile DMZS4P7 MI TTHS256 DMZS4P7 MN Metabotropic glutamate receptor 5 (mGluR5) DMZS4P7 MT DTT DMZS4P7 MA Inhibitor DMZS4P7 RN Rational design of 7-arylquinolines as non-competitive metabotropic glutamate receptor subtype 5 antagonists. Bioorg Med Chem Lett. 2007 Aug 15;17(16):4415-8. DMZS4P7 RU https://pubmed.ncbi.nlm.nih.gov/17590335 DMYR350 DI DMYR350 DMYR350 DN 3-Hydroxy-6-methyl-1H-benzo[b]azepine-2,5-dione DMYR350 MI TTLD29N DMYR350 MN Glutamate receptor ionotropic NMDA 1 (NMDAR1) DMYR350 MT DTT DMYR350 MA Inhibitor DMYR350 RN Analogs of 3-hydroxy-1H-1-benzazepine-2,5-dione: structure-activity relationship at N-methyl-D-aspartate receptor glycine sites. J Med Chem. 1996 Nov 8;39(23):4643-53. DMYR350 RU https://pubmed.ncbi.nlm.nih.gov/8917653 DMYR350 DI DMYR350 DMYR350 DN 3-Hydroxy-6-methyl-1H-benzo[b]azepine-2,5-dione DMYR350 MI TTKJEMQ DMYR350 MN Glutamate receptor ionotropic NMDA 2A (NMDAR2A) DMYR350 MT DTT DMYR350 MA Inhibitor DMYR350 RN Analogs of 3-hydroxy-1H-1-benzazepine-2,5-dione: structure-activity relationship at N-methyl-D-aspartate receptor glycine sites. J Med Chem. 1996 Nov 8;39(23):4643-53. DMYR350 RU https://pubmed.ncbi.nlm.nih.gov/8917653 DMYR350 DI DMYR350 DMYR350 DN 3-Hydroxy-6-methyl-1H-benzo[b]azepine-2,5-dione DMYR350 MI TTN9D8E DMYR350 MN Glutamate receptor ionotropic NMDA 2B (NMDAR2B) DMYR350 MT DTT DMYR350 MA Inhibitor DMYR350 RN Analogs of 3-hydroxy-1H-1-benzazepine-2,5-dione: structure-activity relationship at N-methyl-D-aspartate receptor glycine sites. J Med Chem. 1996 Nov 8;39(23):4643-53. DMYR350 RU https://pubmed.ncbi.nlm.nih.gov/8917653 DM3SOFX DI DM3SOFX DM3SOFX DN 3-Hydroxy-7-(3-hydroxyphenyl)-1-naphthonitrile DM3SOFX MI TTIWB6L DM3SOFX MN Estradiol 17 beta-dehydrogenase 1 (17-beta-HSD1) DM3SOFX MT DTT DM3SOFX MA Inhibitor DM3SOFX RN Substituted 6-phenyl-2-naphthols. Potent and selective nonsteroidal inhibitors of 17beta-hydroxysteroid dehydrogenase type 1 (17beta-HSD1): design,... J Med Chem. 2008 Aug 14;51(15):4685-98. DM3SOFX RU https://pubmed.ncbi.nlm.nih.gov/18630892 DMTEJOY DI DMTEJOY DMTEJOY DN 3-Hydroxy-7-nitro-1H-benzo[b]azepine-2,5-dione DMTEJOY MI TTLD29N DMTEJOY MN Glutamate receptor ionotropic NMDA 1 (NMDAR1) DMTEJOY MT DTT DMTEJOY MA Inhibitor DMTEJOY RN Analogs of 3-hydroxy-1H-1-benzazepine-2,5-dione: structure-activity relationship at N-methyl-D-aspartate receptor glycine sites. J Med Chem. 1996 Nov 8;39(23):4643-53. DMTEJOY RU https://pubmed.ncbi.nlm.nih.gov/8917653 DMTEJOY DI DMTEJOY DMTEJOY DN 3-Hydroxy-7-nitro-1H-benzo[b]azepine-2,5-dione DMTEJOY MI TTKJEMQ DMTEJOY MN Glutamate receptor ionotropic NMDA 2A (NMDAR2A) DMTEJOY MT DTT DMTEJOY MA Inhibitor DMTEJOY RN Analogs of 3-hydroxy-1H-1-benzazepine-2,5-dione: structure-activity relationship at N-methyl-D-aspartate receptor glycine sites. J Med Chem. 1996 Nov 8;39(23):4643-53. DMTEJOY RU https://pubmed.ncbi.nlm.nih.gov/8917653 DMTEJOY DI DMTEJOY DMTEJOY DN 3-Hydroxy-7-nitro-1H-benzo[b]azepine-2,5-dione DMTEJOY MI TTN9D8E DMTEJOY MN Glutamate receptor ionotropic NMDA 2B (NMDAR2B) DMTEJOY MT DTT DMTEJOY MA Inhibitor DMTEJOY RN Analogs of 3-hydroxy-1H-1-benzazepine-2,5-dione: structure-activity relationship at N-methyl-D-aspartate receptor glycine sites. J Med Chem. 1996 Nov 8;39(23):4643-53. DMTEJOY RU https://pubmed.ncbi.nlm.nih.gov/8917653 DM3H56L DI DM3H56L DM3H56L DN 3-hydroxy-8,10-dimethyl-6H-benzo[c]chromen-6-one DM3H56L MI TTZAYWL DM3H56L MN Estrogen receptor (ESR) DM3H56L MT DTT DM3H56L MA Inhibitor DM3H56L RN 6H-Benzo[c]chromen-6-one derivatives as selective ERbeta agonists. Bioorg Med Chem Lett. 2006 Mar 15;16(6):1468-72. DM3H56L RU https://pubmed.ncbi.nlm.nih.gov/16412638 DM3H56L DI DM3H56L DM3H56L DN 3-hydroxy-8,10-dimethyl-6H-benzo[c]chromen-6-one DM3H56L MI TTOM3J0 DM3H56L MN Estrogen receptor beta (ESR2) DM3H56L MT DTT DM3H56L MA Inhibitor DM3H56L RN 6H-Benzo[c]chromen-6-one derivatives as selective ERbeta agonists. Bioorg Med Chem Lett. 2006 Mar 15;16(6):1468-72. DM3H56L RU https://pubmed.ncbi.nlm.nih.gov/16412638 DM7HKIF DI DM7HKIF DM7HKIF DN 3-Hydroxy-8-methyl-1H-benzo[b]azepine-2,5-dione DM7HKIF MI TTLD29N DM7HKIF MN Glutamate receptor ionotropic NMDA 1 (NMDAR1) DM7HKIF MT DTT DM7HKIF MA Inhibitor DM7HKIF RN Analogs of 3-hydroxy-1H-1-benzazepine-2,5-dione: structure-activity relationship at N-methyl-D-aspartate receptor glycine sites. J Med Chem. 1996 Nov 8;39(23):4643-53. DM7HKIF RU https://pubmed.ncbi.nlm.nih.gov/8917653 DM7HKIF DI DM7HKIF DM7HKIF DN 3-Hydroxy-8-methyl-1H-benzo[b]azepine-2,5-dione DM7HKIF MI TTKJEMQ DM7HKIF MN Glutamate receptor ionotropic NMDA 2A (NMDAR2A) DM7HKIF MT DTT DM7HKIF MA Inhibitor DM7HKIF RN Analogs of 3-hydroxy-1H-1-benzazepine-2,5-dione: structure-activity relationship at N-methyl-D-aspartate receptor glycine sites. J Med Chem. 1996 Nov 8;39(23):4643-53. DM7HKIF RU https://pubmed.ncbi.nlm.nih.gov/8917653 DM7HKIF DI DM7HKIF DM7HKIF DN 3-Hydroxy-8-methyl-1H-benzo[b]azepine-2,5-dione DM7HKIF MI TTN9D8E DM7HKIF MN Glutamate receptor ionotropic NMDA 2B (NMDAR2B) DM7HKIF MT DTT DM7HKIF MA Inhibitor DM7HKIF RN Analogs of 3-hydroxy-1H-1-benzazepine-2,5-dione: structure-activity relationship at N-methyl-D-aspartate receptor glycine sites. J Med Chem. 1996 Nov 8;39(23):4643-53. DM7HKIF RU https://pubmed.ncbi.nlm.nih.gov/8917653 DMNV1P3 DI DMNV1P3 DMNV1P3 DN 3-Hydroxy-benzamide DMNV1P3 MI TTVDSZ0 DMNV1P3 MN Poly [ADP-ribose] polymerase 1 (PARP1) DMNV1P3 MT DTT DMNV1P3 MA Inhibitor DMNV1P3 RN Resistance-modifying agents. 5. Synthesis and biological properties of quinazolinone inhibitors of the DNA repair enzyme poly(ADP-ribose) polymeras... J Med Chem. 1998 Dec 17;41(26):5247-56. DMNV1P3 RU https://pubmed.ncbi.nlm.nih.gov/9857092 DMNUM4K DI DMNUM4K DMNUM4K DN 3-hydroxybenzylhydrazine DMNUM4K MI TTN451K DMNUM4K MN Aromatic-L-amino-acid decarboxylase (DDC) DMNUM4K MT DTT DMNUM4K MA Inhibitor DMNUM4K RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1271). DMNUM4K RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1271 DM5T6AM DI DM5T6AM DM5T6AM DN 3-hydroxydesaminokynurenine DM5T6AM MI TTWQM3J DM5T6AM MN Kynureninase (KYNU) DM5T6AM MT DTT DM5T6AM MA Inhibitor DM5T6AM RN Comparative inhibition by substrate analogues 3-methoxy- and 3-hydroxydesaminokynurenine and an improved 3 step purification of recombinant human kynureninase. BMC Biochem. 2003 Sep 24;4:13. DM5T6AM RU https://pubmed.ncbi.nlm.nih.gov/14505498 DM2LBFW DI DM2LBFW DM2LBFW DN 3-Hydroxyhippuric acid DM2LBFW MI TTWQM3J DM2LBFW MN Kynureninase (KYNU) DM2LBFW MT DTT DM2LBFW MA Inhibitor DM2LBFW RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DM2LBFW RU https://pubmed.ncbi.nlm.nih.gov/10592235 DMKLZXV DI DMKLZXV DMKLZXV DN 3-Hydroxyisoxazole-4-Carboxylic Acid DMKLZXV MI TTAZHU0 DMKLZXV MN L-lactate dehydrogenase (LDH) DMKLZXV MT DTT DMKLZXV MA Inhibitor DMKLZXV RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMKLZXV RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMNMB6V DI DMNMB6V DMNMB6V DN 3-hydroxylauric acid DMNMB6V MI TTG0MQD DMNMB6V MN Inflammation-related GPCR EX33 (GPR84) DMNMB6V MT DTT DMNMB6V MA Agonist DMNMB6V RN Medium-chain fatty acid-sensing receptor, GPR84, is a proinflammatory receptor. J Biol Chem. 2013 Apr 12;288(15):10684-91. DMNMB6V RU https://pubmed.ncbi.nlm.nih.gov/23449982 DMFJLWO DI DMFJLWO DMFJLWO DN 3-Hydroxy-Myristic Acid DMFJLWO MI TT8S9AV DMFJLWO MN Lymphocyte antigen 96 (LY96) DMFJLWO MT DTT DMFJLWO MA Inhibitor DMFJLWO RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMFJLWO RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMFJLWO DI DMFJLWO DMFJLWO DN 3-Hydroxy-Myristic Acid DMFJLWO MI TTISGCA DMFJLWO MN Toll-like receptor 4 (TLR4) DMFJLWO MT DTT DMFJLWO MA Inhibitor DMFJLWO RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMFJLWO RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMXO98C DI DMXO98C DMXO98C DN 3-hydroxy-N,N,N-trimethylbenzenaminium iodide DMXO98C MI TT1RS9F DMXO98C MN Acetylcholinesterase (AChE) DMXO98C MT DTT DMXO98C MA Inhibitor DMXO98C RN Homo- and hetero-bivalent edrophonium-like ammonium salts as highly potent, dual binding site AChE inhibitors. Bioorg Med Chem. 2008 Aug 1;16(15):7450-6. DMXO98C RU https://pubmed.ncbi.nlm.nih.gov/18585045 DMS658R DI DMS658R DMS658R DN 3-hydroxyoctanoic acid DMS658R MI TT8WFXV DMS658R MN Hydroxycarboxylic acid receptor 3 (HCAR3) DMS658R MT DTT DMS658R MA Agonist DMS658R RN Deorphanization of GPR109B as a receptor for the beta-oxidation intermediate 3-OH-octanoic acid and its role in the regulation of lipolysis. J Biol Chem. 2009 Aug 14;284(33):21928-33. DMS658R RU https://pubmed.ncbi.nlm.nih.gov/19561068 DMMAK83 DI DMMAK83 DMMAK83 DN 3-hydroxyphenethyl 3,4,5-trihydroxybenzoate DMMAK83 MI TTULVH8 DMMAK83 MN Tyrosinase (TYR) DMMAK83 MT DTT DMMAK83 MA Inhibitor DMMAK83 RN Synthetic tyrosyl gallate derivatives as potent melanin formation inhibitors. Bioorg Med Chem Lett. 2007 Oct 1;17(19):5462-4. DMMAK83 RU https://pubmed.ncbi.nlm.nih.gov/17693086 DM5OR96 DI DM5OR96 DM5OR96 DN 3-Hydroxy-piperidine-4-carboxylic acid DM5OR96 MI TTNJYV2 DM5OR96 MN Gamma-aminobutyric acid receptor (GAR) DM5OR96 MT DTT DM5OR96 MA Inhibitor DM5OR96 RN Hydroxy- and amino-substituted piperidinecarboxylic acids as gamma-aminobutyric acid agonists and uptake inhibitors. J Med Chem. 1982 Oct;25(10):1157-62. DM5OR96 RU https://pubmed.ncbi.nlm.nih.gov/6292417 DM67QDT DI DM67QDT DM67QDT DN 3-Hydroxypyruvic Acid DM67QDT MI TTNS6X4 DM67QDT MN Bacterial Triosephosphate isomerase (Bact TPI) DM67QDT MT DTT DM67QDT MA Inhibitor DM67QDT RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DM67QDT RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMCXZ9L DI DMCXZ9L DMCXZ9L DN 3-hydroxyquinazoline-2,4(1H,3H)-dione DMCXZ9L MI TT37KAF DMCXZ9L MN Human immunodeficiency virus Ribonuclease H (HIV RNH) DMCXZ9L MT DTT DMCXZ9L MA Inhibitor DMCXZ9L RN RNase H active site inhibitors of human immunodeficiency virus type 1 reverse transcriptase: design, biochemical activity, and structural information. J Med Chem. 2009 Oct 8;52(19):5781-4. DMCXZ9L RU https://pubmed.ncbi.nlm.nih.gov/19791799 DMBZ60O DI DMBZ60O DMBZ60O DN 3-Imidazol-1-ylmethyl-1H-indole DMBZ60O MI TTIQUX7 DMBZ60O MN Steroid 11-beta-hydroxylase (CYP11B1) DMBZ60O MT DTT DMBZ60O MA Inhibitor DMBZ60O RN Selective thromboxane synthetase inhibitors. 2. 3-(1H-imidazol-1-ylmethyl)-2-methyl-1H-indole-1-propanoic acid and analogues. J Med Chem. 1986 Mar;29(3):342-6. DMBZ60O RU https://pubmed.ncbi.nlm.nih.gov/3081722 DMAQOL0 DI DMAQOL0 DMAQOL0 DN 3-Imidazol-1-ylmethyl-2-isopropyl-1H-indole DMAQOL0 MI TTIQUX7 DMAQOL0 MN Steroid 11-beta-hydroxylase (CYP11B1) DMAQOL0 MT DTT DMAQOL0 MA Inhibitor DMAQOL0 RN Selective thromboxane synthetase inhibitors. 2. 3-(1H-imidazol-1-ylmethyl)-2-methyl-1H-indole-1-propanoic acid and analogues. J Med Chem. 1986 Mar;29(3):342-6. DMAQOL0 RU https://pubmed.ncbi.nlm.nih.gov/3081722 DMVF6OQ DI DMVF6OQ DMVF6OQ DN 3-Imidazol-1-yl-quinoline DMVF6OQ MI TTIQUX7 DMVF6OQ MN Steroid 11-beta-hydroxylase (CYP11B1) DMVF6OQ MT DTT DMVF6OQ MA Inhibitor DMVF6OQ RN Heteroaryl-substituted naphthalenes and structurally modified derivatives: selective inhibitors of CYP11B2 for the treatment of congestive heart fa... J Med Chem. 2005 Oct 20;48(21):6632-42. DMVF6OQ RU https://pubmed.ncbi.nlm.nih.gov/16220979 DMYH6A2 DI DMYH6A2 DMYH6A2 DN 3-Indan-(1E)-ylidenemethyl-pyridine DMYH6A2 MI TTSZLWK DMYH6A2 MN Aromatase (CYP19A1) DMYH6A2 MT DTT DMYH6A2 MA Inhibitor DMYH6A2 RN Synthesis and evaluation of (pyridylmethylene)tetrahydronaphthalenes/-indanes and structurally modified derivatives: potent and selective inhibitor... J Med Chem. 2005 Mar 10;48(5):1563-75. DMYH6A2 RU https://pubmed.ncbi.nlm.nih.gov/15743198 DMYH6A2 DI DMYH6A2 DMYH6A2 DN 3-Indan-(1E)-ylidenemethyl-pyridine DMYH6A2 MI TTIQUX7 DMYH6A2 MN Steroid 11-beta-hydroxylase (CYP11B1) DMYH6A2 MT DTT DMYH6A2 MA Inhibitor DMYH6A2 RN Synthesis and evaluation of (pyridylmethylene)tetrahydronaphthalenes/-indanes and structurally modified derivatives: potent and selective inhibitor... J Med Chem. 2005 Mar 10;48(5):1563-75. DMYH6A2 RU https://pubmed.ncbi.nlm.nih.gov/15743198 DMTQERW DI DMTQERW DMTQERW DN 3-Indan-(1Z)-ylidenemethyl-pyridine DMTQERW MI TTSZLWK DMTQERW MN Aromatase (CYP19A1) DMTQERW MT DTT DMTQERW MA Inhibitor DMTQERW RN Synthesis and evaluation of (pyridylmethylene)tetrahydronaphthalenes/-indanes and structurally modified derivatives: potent and selective inhibitor... J Med Chem. 2005 Mar 10;48(5):1563-75. DMTQERW RU https://pubmed.ncbi.nlm.nih.gov/15743198 DMTQERW DI DMTQERW DMTQERW DN 3-Indan-(1Z)-ylidenemethyl-pyridine DMTQERW MI TTIQUX7 DMTQERW MN Steroid 11-beta-hydroxylase (CYP11B1) DMTQERW MT DTT DMTQERW MA Inhibitor DMTQERW RN Synthesis and evaluation of (pyridylmethylene)tetrahydronaphthalenes/-indanes and structurally modified derivatives: potent and selective inhibitor... J Med Chem. 2005 Mar 10;48(5):1563-75. DMTQERW RU https://pubmed.ncbi.nlm.nih.gov/15743198 DM890WJ DI DM890WJ DM890WJ DN 3-Iodoboldine DM890WJ MI TTZFYLI DM890WJ MN Dopamine D1 receptor (D1R) DM890WJ MT DTT DM890WJ MA Inhibitor DM890WJ RN Halogenated boldine derivatives with enhanced monoamine receptor selectivity. J Nat Prod. 2000 Apr;63(4):480-4. DM890WJ RU https://pubmed.ncbi.nlm.nih.gov/10785418 DM890WJ DI DM890WJ DM890WJ DN 3-Iodoboldine DM890WJ MI TTEX248 DM890WJ MN Dopamine D2 receptor (D2R) DM890WJ MT DTT DM890WJ MA Inhibitor DM890WJ RN Halogenated boldine derivatives with enhanced monoamine receptor selectivity. J Nat Prod. 2000 Apr;63(4):480-4. DM890WJ RU https://pubmed.ncbi.nlm.nih.gov/10785418 DMDSJ0O DI DMDSJ0O DMDSJ0O DN 3-iodo-N-(6-methylpyridin-2-yl)benzamide DMDSJ0O MI TTHS256 DMDSJ0O MN Metabotropic glutamate receptor 5 (mGluR5) DMDSJ0O MT DTT DMDSJ0O MA Inhibitor DMDSJ0O RN Design and synthesis of noncompetitive metabotropic glutamate receptor subtype 5 antagonists. Bioorg Med Chem Lett. 2006 Jul 1;16(13):3371-5. DMDSJ0O RU https://pubmed.ncbi.nlm.nih.gov/16678408 DM3L0F8 DI DM3L0F8 DM3L0F8 DN 3-iodothyronamine DM3L0F8 MI TTIU98M DM3L0F8 MN Trace amine-associated receptor-1 (TAAR1) DM3L0F8 MT DTT DM3L0F8 MA Agonist DM3L0F8 RN Exploring the structure-activity relationship of the ethylamine portion of 3-iodothyronamine for rat and mouse trace amine-associated receptor 1. J Med Chem. 2007 Jun 14;50(12):2787-98. DM3L0F8 RU https://pubmed.ncbi.nlm.nih.gov/17497842 DMNZMH6 DI DMNZMH6 DMNZMH6 DN 3-iodotyrosine DMNZMH6 MI TTUHP71 DMNZMH6 MN Tyrosine 3-monooxygenase (TH) DMNZMH6 MT DTT DMNZMH6 MA Inhibitor DMNZMH6 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1243). DMNZMH6 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1243 DMJSLVT DI DMJSLVT DMJSLVT DN 3-Iodyl-benzoic acid DMJSLVT MI TTELIN2 DMJSLVT MN PTPN1 messenger RNA (PTPN1 mRNA) DMJSLVT MT DTT DMJSLVT MA Inhibitor DMJSLVT RN Periodinates: a new class of protein tyrosine phosphatase inhibitors. Bioorg Med Chem Lett. 1999 Feb 8;9(3):353-6. DMJSLVT RU https://pubmed.ncbi.nlm.nih.gov/10091683 DMWP0LZ DI DMWP0LZ DMWP0LZ DN 3-isobutoxy-5-(2-methylquinolin-7-yl)benzonitrile DMWP0LZ MI TTHS256 DMWP0LZ MN Metabotropic glutamate receptor 5 (mGluR5) DMWP0LZ MT DTT DMWP0LZ MA Inhibitor DMWP0LZ RN Rational design of 7-arylquinolines as non-competitive metabotropic glutamate receptor subtype 5 antagonists. Bioorg Med Chem Lett. 2007 Aug 15;17(16):4415-8. DMWP0LZ RU https://pubmed.ncbi.nlm.nih.gov/17590335 DM6X5TZ DI DM6X5TZ DM6X5TZ DN 3-Isobutoxy-9H-beta-carboline DM6X5TZ MI TT1MPAY DM6X5TZ MN GABA(A) receptor alpha-1 (GABRA1) DM6X5TZ MT DTT DM6X5TZ MA Inhibitor DM6X5TZ RN Predictive binding of beta-carboline inverse agonists and antagonists via the CoMFA/GOLPE approach. J Med Chem. 1992 Oct 30;35(22):4001-10. DM6X5TZ RU https://pubmed.ncbi.nlm.nih.gov/1331452 DM6X5TZ DI DM6X5TZ DM6X5TZ DN 3-Isobutoxy-9H-beta-carboline DM6X5TZ MI TTBMV1G DM6X5TZ MN GABA(A) receptor alpha-2 (GABRA2) DM6X5TZ MT DTT DM6X5TZ MA Inhibitor DM6X5TZ RN Design, synthesis, and subtype selectivity of 3,6-disubstituted -carbolines at Bz/GABA(A)ergic receptors. SAR and studies directed toward agents f... Bioorg Med Chem. 2010 Nov 1;18(21):7548-64. DM6X5TZ RU https://pubmed.ncbi.nlm.nih.gov/20888240 DM6X5TZ DI DM6X5TZ DM6X5TZ DN 3-Isobutoxy-9H-beta-carboline DM6X5TZ MI TT37EDJ DM6X5TZ MN GABA(A) receptor alpha-3 (GABRA3) DM6X5TZ MT DTT DM6X5TZ MA Inhibitor DM6X5TZ RN Design, synthesis, and subtype selectivity of 3,6-disubstituted -carbolines at Bz/GABA(A)ergic receptors. SAR and studies directed toward agents f... Bioorg Med Chem. 2010 Nov 1;18(21):7548-64. DM6X5TZ RU https://pubmed.ncbi.nlm.nih.gov/20888240 DM6X5TZ DI DM6X5TZ DM6X5TZ DN 3-Isobutoxy-9H-beta-carboline DM6X5TZ MI TTNZPQ1 DM6X5TZ MN GABA(A) receptor alpha-5 (GABRA5) DM6X5TZ MT DTT DM6X5TZ MA Inhibitor DM6X5TZ RN Design, synthesis, and subtype selectivity of 3,6-disubstituted -carbolines at Bz/GABA(A)ergic receptors. SAR and studies directed toward agents f... Bioorg Med Chem. 2010 Nov 1;18(21):7548-64. DM6X5TZ RU https://pubmed.ncbi.nlm.nih.gov/20888240 DM6X5TZ DI DM6X5TZ DM6X5TZ DN 3-Isobutoxy-9H-beta-carboline DM6X5TZ MI TT06RH5 DM6X5TZ MN GABA(A) receptor gamma-2 (GABRG2) DM6X5TZ MT DTT DM6X5TZ MA Inhibitor DM6X5TZ RN Design, synthesis, and subtype selectivity of 3,6-disubstituted -carbolines at Bz/GABA(A)ergic receptors. SAR and studies directed toward agents f... Bioorg Med Chem. 2010 Nov 1;18(21):7548-64. DM6X5TZ RU https://pubmed.ncbi.nlm.nih.gov/20888240 DM6X5TZ DI DM6X5TZ DM6X5TZ DN 3-Isobutoxy-9H-beta-carboline DM6X5TZ MI TTNJYV2 DM6X5TZ MN Gamma-aminobutyric acid receptor (GAR) DM6X5TZ MT DTT DM6X5TZ MA Inhibitor DM6X5TZ RN Predictive binding of beta-carboline inverse agonists and antagonists via the CoMFA/GOLPE approach. J Med Chem. 1992 Oct 30;35(22):4001-10. DM6X5TZ RU https://pubmed.ncbi.nlm.nih.gov/1331452 DMQXP7C DI DMQXP7C DMQXP7C DN 3-Isobutyl-[1,4]thiazepan-(5E)-ylideneamine DMQXP7C MI TTZUFI5 DMQXP7C MN Nitric-oxide synthase brain (NOS1) DMQXP7C MT DTT DMQXP7C MA Inhibitor DMQXP7C RN Synthesis of analogs of (1,4)-3- and 5-imino oxazepane, thiazepane, and diazepane as inhibitors of nitric oxide synthases. Bioorg Med Chem Lett. 2004 Dec 6;14(23):5907-11. DMQXP7C RU https://pubmed.ncbi.nlm.nih.gov/15501067 DMQXP7C DI DMQXP7C DMQXP7C DN 3-Isobutyl-[1,4]thiazepan-(5E)-ylideneamine DMQXP7C MI TTF10I9 DMQXP7C MN Nitric-oxide synthase inducible (NOS2) DMQXP7C MT DTT DMQXP7C MA Inhibitor DMQXP7C RN Synthesis of analogs of (1,4)-3- and 5-imino oxazepane, thiazepane, and diazepane as inhibitors of nitric oxide synthases. Bioorg Med Chem Lett. 2004 Dec 6;14(23):5907-11. DMQXP7C RU https://pubmed.ncbi.nlm.nih.gov/15501067 DM9GM1H DI DM9GM1H DM9GM1H DN 3-isobutyl-8-pyrrolidinoxanthine DM9GM1H MI TTNE7KG DM9GM1H MN Adenosine A2b receptor (ADORA2B) DM9GM1H MT DTT DM9GM1H MA Antagonist DM9GM1H RN Inhibition of human mast cell activation with the novel selective adenosine A(2B) receptor antagonist 3-isobutyl-8-pyrrolidinoxanthine (IPDX)(2). Biochem Pharmacol. 2001 Nov 1;62(9):1163-73. DM9GM1H RU https://pubmed.ncbi.nlm.nih.gov/11705449 DM7PHO4 DI DM7PHO4 DM7PHO4 DN 3-Isopropoxy-9H-beta-carboline DM7PHO4 MI TT1MPAY DM7PHO4 MN GABA(A) receptor alpha-1 (GABRA1) DM7PHO4 MT DTT DM7PHO4 MA Inhibitor DM7PHO4 RN Predictive binding of beta-carboline inverse agonists and antagonists via the CoMFA/GOLPE approach. J Med Chem. 1992 Oct 30;35(22):4001-10. DM7PHO4 RU https://pubmed.ncbi.nlm.nih.gov/1331452 DM7PHO4 DI DM7PHO4 DM7PHO4 DN 3-Isopropoxy-9H-beta-carboline DM7PHO4 MI TTNJYV2 DM7PHO4 MN Gamma-aminobutyric acid receptor (GAR) DM7PHO4 MT DTT DM7PHO4 MA Inhibitor DM7PHO4 RN Predictive binding of beta-carboline inverse agonists and antagonists via the CoMFA/GOLPE approach. J Med Chem. 1992 Oct 30;35(22):4001-10. DM7PHO4 RU https://pubmed.ncbi.nlm.nih.gov/1331452 DMYKVRF DI DMYKVRF DMYKVRF DN 3-Isopropyl-1-methyl-3,7-dihydro-purine-2,6-dione DMYKVRF MI TTM2AOE DMYKVRF MN Adenosine A2a receptor (ADORA2A) DMYKVRF MT DTT DMYKVRF MA Inhibitor DMYKVRF RN Analogues of caffeine and theophylline: effect of structural alterations on affinity at adenosine receptors. J Med Chem. 1986 Jul;29(7):1305-8. DMYKVRF RU https://pubmed.ncbi.nlm.nih.gov/3806581 DMSLPGZ DI DMSLPGZ DMSLPGZ DN 3-Isopropyl-3-methyl-dihydro-furan-2-one DMSLPGZ MI TT1MPAY DMSLPGZ MN GABA(A) receptor alpha-1 (GABRA1) DMSLPGZ MT DTT DMSLPGZ MA Inhibitor DMSLPGZ RN Alpha-spirocyclopentyl- and alpha-spirocyclopropyl-gamma-butyrolactones: conformationally constrained derivatives of anticonvulsant and convulsant ... J Med Chem. 1994 Jan 21;37(2):275-86. DMSLPGZ RU https://pubmed.ncbi.nlm.nih.gov/8295215 DMSLPGZ DI DMSLPGZ DMSLPGZ DN 3-Isopropyl-3-methyl-dihydro-furan-2-one DMSLPGZ MI TTZA1NY DMSLPGZ MN GABA(A) receptor beta-2 (GABRB2) DMSLPGZ MT DTT DMSLPGZ MA Inhibitor DMSLPGZ RN Alpha-spirocyclopentyl- and alpha-spirocyclopropyl-gamma-butyrolactones: conformationally constrained derivatives of anticonvulsant and convulsant ... J Med Chem. 1994 Jan 21;37(2):275-86. DMSLPGZ RU https://pubmed.ncbi.nlm.nih.gov/8295215 DMSLPGZ DI DMSLPGZ DMSLPGZ DN 3-Isopropyl-3-methyl-dihydro-furan-2-one DMSLPGZ MI TT06RH5 DMSLPGZ MN GABA(A) receptor gamma-2 (GABRG2) DMSLPGZ MT DTT DMSLPGZ MA Inhibitor DMSLPGZ RN Alpha-spirocyclopentyl- and alpha-spirocyclopropyl-gamma-butyrolactones: conformationally constrained derivatives of anticonvulsant and convulsant ... J Med Chem. 1994 Jan 21;37(2):275-86. DMSLPGZ RU https://pubmed.ncbi.nlm.nih.gov/8295215 DMSLPGZ DI DMSLPGZ DMSLPGZ DN 3-Isopropyl-3-methyl-dihydro-furan-2-one DMSLPGZ MI TTNJYV2 DMSLPGZ MN Gamma-aminobutyric acid receptor (GAR) DMSLPGZ MT DTT DMSLPGZ MA Inhibitor DMSLPGZ RN Alpha-spirocyclopentyl- and alpha-spirocyclopropyl-gamma-butyrolactones: conformationally constrained derivatives of anticonvulsant and convulsant ... J Med Chem. 1994 Jan 21;37(2):275-86. DMSLPGZ RU https://pubmed.ncbi.nlm.nih.gov/8295215 DMHAJ6W DI DMHAJ6W DMHAJ6W DN 3-isopropyl-4-(phenylamino)naphthalene-1,2-dione DMHAJ6W MI TTLZS4Q DMHAJ6W MN M-phase inducer phosphatase 1 (MPIP1) DMHAJ6W MT DTT DMHAJ6W MA Inhibitor DMHAJ6W RN Synthesis of miltirone analogues as inhibitors of Cdc25 phosphatases. Bioorg Med Chem Lett. 2006 Apr 1;16(7):1905-8. DMHAJ6W RU https://pubmed.ncbi.nlm.nih.gov/16434190 DMHAJ6W DI DMHAJ6W DMHAJ6W DN 3-isopropyl-4-(phenylamino)naphthalene-1,2-dione DMHAJ6W MI TTR0SWN DMHAJ6W MN M-phase inducer phosphatase 2 (MPIP2) DMHAJ6W MT DTT DMHAJ6W MA Inhibitor DMHAJ6W RN Synthesis of miltirone analogues as inhibitors of Cdc25 phosphatases. Bioorg Med Chem Lett. 2006 Apr 1;16(7):1905-8. DMHAJ6W RU https://pubmed.ncbi.nlm.nih.gov/16434190 DMJZEMB DI DMJZEMB DMJZEMB DN 3-isopropyl-4-(phenylthio)naphthalene-1,2-dione DMJZEMB MI TTLZS4Q DMJZEMB MN M-phase inducer phosphatase 1 (MPIP1) DMJZEMB MT DTT DMJZEMB MA Inhibitor DMJZEMB RN Synthesis of miltirone analogues as inhibitors of Cdc25 phosphatases. Bioorg Med Chem Lett. 2006 Apr 1;16(7):1905-8. DMJZEMB RU https://pubmed.ncbi.nlm.nih.gov/16434190 DMJZEMB DI DMJZEMB DMJZEMB DN 3-isopropyl-4-(phenylthio)naphthalene-1,2-dione DMJZEMB MI TTR0SWN DMJZEMB MN M-phase inducer phosphatase 2 (MPIP2) DMJZEMB MT DTT DMJZEMB MA Inhibitor DMJZEMB RN Synthesis of miltirone analogues as inhibitors of Cdc25 phosphatases. Bioorg Med Chem Lett. 2006 Apr 1;16(7):1905-8. DMJZEMB RU https://pubmed.ncbi.nlm.nih.gov/16434190 DMJZEMB DI DMJZEMB DMJZEMB DN 3-isopropyl-4-(phenylthio)naphthalene-1,2-dione DMJZEMB MI TTELIN2 DMJZEMB MN PTPN1 messenger RNA (PTPN1 mRNA) DMJZEMB MT DTT DMJZEMB MA Inhibitor DMJZEMB RN Synthesis of miltirone analogues as inhibitors of Cdc25 phosphatases. Bioorg Med Chem Lett. 2006 Apr 1;16(7):1905-8. DMJZEMB RU https://pubmed.ncbi.nlm.nih.gov/16434190 DMYZCWX DI DMYZCWX DMYZCWX DN 3-isopropyl-4-phenylnaphthalene-1,2-dione DMYZCWX MI TTLZS4Q DMYZCWX MN M-phase inducer phosphatase 1 (MPIP1) DMYZCWX MT DTT DMYZCWX MA Inhibitor DMYZCWX RN Synthesis of miltirone analogues as inhibitors of Cdc25 phosphatases. Bioorg Med Chem Lett. 2006 Apr 1;16(7):1905-8. DMYZCWX RU https://pubmed.ncbi.nlm.nih.gov/16434190 DMYZCWX DI DMYZCWX DMYZCWX DN 3-isopropyl-4-phenylnaphthalene-1,2-dione DMYZCWX MI TTR0SWN DMYZCWX MN M-phase inducer phosphatase 2 (MPIP2) DMYZCWX MT DTT DMYZCWX MA Inhibitor DMYZCWX RN Synthesis of miltirone analogues as inhibitors of Cdc25 phosphatases. Bioorg Med Chem Lett. 2006 Apr 1;16(7):1905-8. DMYZCWX RU https://pubmed.ncbi.nlm.nih.gov/16434190 DM46ID2 DI DM46ID2 DM46ID2 DN 3-isopropylnaphthalene-1,2-dione DM46ID2 MI TTLZS4Q DM46ID2 MN M-phase inducer phosphatase 1 (MPIP1) DM46ID2 MT DTT DM46ID2 MA Inhibitor DM46ID2 RN Synthesis of miltirone analogues as inhibitors of Cdc25 phosphatases. Bioorg Med Chem Lett. 2006 Apr 1;16(7):1905-8. DM46ID2 RU https://pubmed.ncbi.nlm.nih.gov/16434190 DMZPGBT DI DMZPGBT DMZPGBT DN 3-isopr-sal-cyclosal-d4TMP DMZPGBT MI TTEB0GD DMZPGBT MN Cholinesterase (BCHE) DMZPGBT MT DTT DMZPGBT MA Inhibitor DMZPGBT RN Bis-cycloSal-d4T-monophosphates: drugs that deliver two molecules of bioactive nucleotides. J Med Chem. 2007 Mar 22;50(6):1335-46. DMZPGBT RU https://pubmed.ncbi.nlm.nih.gov/17328534 DM9LEWH DI DM9LEWH DM9LEWH DN 3-Isothiocyanato-9H-beta-carboline DM9LEWH MI TT1MPAY DM9LEWH MN GABA(A) receptor alpha-1 (GABRA1) DM9LEWH MT DTT DM9LEWH MA Inhibitor DM9LEWH RN Synthetic and computer-assisted analyses of the pharmacophore for the benzodiazepine receptor inverse agonist site. J Med Chem. 1990 Sep;33(9):2343-57. DM9LEWH RU https://pubmed.ncbi.nlm.nih.gov/2167977 DM9LEWH DI DM9LEWH DM9LEWH DN 3-Isothiocyanato-9H-beta-carboline DM9LEWH MI TTZA1NY DM9LEWH MN GABA(A) receptor beta-2 (GABRB2) DM9LEWH MT DTT DM9LEWH MA Inhibitor DM9LEWH RN Synthetic and computer-assisted analyses of the pharmacophore for the benzodiazepine receptor inverse agonist site. J Med Chem. 1990 Sep;33(9):2343-57. DM9LEWH RU https://pubmed.ncbi.nlm.nih.gov/2167977 DM9LEWH DI DM9LEWH DM9LEWH DN 3-Isothiocyanato-9H-beta-carboline DM9LEWH MI TT06RH5 DM9LEWH MN GABA(A) receptor gamma-2 (GABRG2) DM9LEWH MT DTT DM9LEWH MA Inhibitor DM9LEWH RN Synthetic and computer-assisted analyses of the pharmacophore for the benzodiazepine receptor inverse agonist site. J Med Chem. 1990 Sep;33(9):2343-57. DM9LEWH RU https://pubmed.ncbi.nlm.nih.gov/2167977 DM9LEWH DI DM9LEWH DM9LEWH DN 3-Isothiocyanato-9H-beta-carboline DM9LEWH MI TTNJYV2 DM9LEWH MN Gamma-aminobutyric acid receptor (GAR) DM9LEWH MT DTT DM9LEWH MA Inhibitor DM9LEWH RN Synthetic and computer-assisted analyses of the pharmacophore for the benzodiazepine receptor inverse agonist site. J Med Chem. 1990 Sep;33(9):2343-57. DM9LEWH RU https://pubmed.ncbi.nlm.nih.gov/2167977 DM5LUED DI DM5LUED DM5LUED DN 3-keto-lithocholic acid DM5LUED MI TT7LCTF DM5LUED MN Pregnane X receptor (NR1I2) DM5LUED MT DTT DM5LUED MA Agonist DM5LUED RN The nuclear receptor PXR is a lithocholic acid sensor that protects against liver toxicity. Proc Natl Acad Sci U S A. 2001 Mar 13;98(6):3369-74. DM5LUED RU https://pubmed.ncbi.nlm.nih.gov/11248085 DM5LUED DI DM5LUED DM5LUED DN 3-keto-lithocholic acid DM5LUED MI TTK59TV DM5LUED MN Vitamin D3 receptor (VDR) DM5LUED MT DTT DM5LUED MA Agonist DM5LUED RN Vitamin D receptor as an intestinal bile acid sensor. Science. 2002 May 17;296(5571):1313-6. DM5LUED RU https://pubmed.ncbi.nlm.nih.gov/12016314 DMRMF13 DI DMRMF13 DMRMF13 DN 3-MATIDA DMRMF13 MI TTVBPDM DMRMF13 MN Metabotropic glutamate receptor 1 (mGluR1) DMRMF13 MT DTT DMRMF13 MA Antagonist DMRMF13 RN The novel and systemically active metabotropic glutamate 1 (mGlu1) receptor antagonist 3-MATIDA reduces post-ischemic neuronal death. Neuropharmacology. 2002 May;42(6):741-51. DMRMF13 RU https://pubmed.ncbi.nlm.nih.gov/12015200 DMPJBNC DI DMPJBNC DMPJBNC DN 3-mercapto-2-(piperidin-3-yl)propanoic acid DMPJBNC MI TTP18AY DMPJBNC MN Carboxypeptidase B2 (CPB2) DMPJBNC MT DTT DMPJBNC MA Inhibitor DMPJBNC RN 3-Mercaptopropionic acids as efficacious inhibitors of activated thrombin activatable fibrinolysis inhibitor (TAFIa). Bioorg Med Chem Lett. 2007 Mar 1;17(5):1349-54. DMPJBNC RU https://pubmed.ncbi.nlm.nih.gov/17189688 DMYQG7A DI DMYQG7A DMYQG7A DN 3-mercapto-2-(piperidin-4-yl)propanoic acid DMYQG7A MI TTP18AY DMYQG7A MN Carboxypeptidase B2 (CPB2) DMYQG7A MT DTT DMYQG7A MA Inhibitor DMYQG7A RN 3-Mercaptopropionic acids as efficacious inhibitors of activated thrombin activatable fibrinolysis inhibitor (TAFIa). Bioorg Med Chem Lett. 2007 Mar 1;17(5):1349-54. DMYQG7A RU https://pubmed.ncbi.nlm.nih.gov/17189688 DMQ09J8 DI DMQ09J8 DMQ09J8 DN 3-mercapto-N-(4-sulfamoyl-phenyl)-propionamide DMQ09J8 MI TTHQPL7 DMQ09J8 MN Carbonic anhydrase I (CA-I) DMQ09J8 MT DTT DMQ09J8 MA Inhibitor DMQ09J8 RN Carbonic anhydrase inhibitors: Hypoxia-activatable sulfonamides incorporating disulfide bonds that target the tumor-associated isoform IX. J Med Chem. 2006 Sep 7;49(18):5544-51. DMQ09J8 RU https://pubmed.ncbi.nlm.nih.gov/16942027 DMQ09J8 DI DMQ09J8 DMQ09J8 DN 3-mercapto-N-(4-sulfamoyl-phenyl)-propionamide DMQ09J8 MI TTANPDJ DMQ09J8 MN Carbonic anhydrase II (CA-II) DMQ09J8 MT DTT DMQ09J8 MA Inhibitor DMQ09J8 RN Carbonic anhydrase inhibitors: Hypoxia-activatable sulfonamides incorporating disulfide bonds that target the tumor-associated isoform IX. J Med Chem. 2006 Sep 7;49(18):5544-51. DMQ09J8 RU https://pubmed.ncbi.nlm.nih.gov/16942027 DMQ09J8 DI DMQ09J8 DMQ09J8 DN 3-mercapto-N-(4-sulfamoyl-phenyl)-propionamide DMQ09J8 MI TT2LVK8 DMQ09J8 MN Carbonic anhydrase IX (CA-IX) DMQ09J8 MT DTT DMQ09J8 MA Inhibitor DMQ09J8 RN Carbonic anhydrase inhibitors: Hypoxia-activatable sulfonamides incorporating disulfide bonds that target the tumor-associated isoform IX. J Med Chem. 2006 Sep 7;49(18):5544-51. DMQ09J8 RU https://pubmed.ncbi.nlm.nih.gov/16942027 DMX3ANZ DI DMX3ANZ DMX3ANZ DN 3-Mercuri-4-Aminobenzenesulfonamide DMX3ANZ MI TTANPDJ DMX3ANZ MN Carbonic anhydrase II (CA-II) DMX3ANZ MT DTT DMX3ANZ MA Inhibitor DMX3ANZ RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMX3ANZ RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMAWEQH DI DMAWEQH DMAWEQH DN 3-MeSO2-DDE DMAWEQH MI TTIQUX7 DMAWEQH MN Steroid 11-beta-hydroxylase (CYP11B1) DMAWEQH MT DTT DMAWEQH MA Inhibitor DMAWEQH RN Effects of 3-MeSO2-DDE and some CYP inhibitors on glucocorticoid steroidogenesis in the H295R human adrenocortical carcinoma cell line. Toxicol In Vitro. 2002 Apr;16(2):113-21. DMAWEQH RU https://pubmed.ncbi.nlm.nih.gov/11869873 DM2QD45 DI DM2QD45 DM2QD45 DN 3-methoxy-4-(m-tolyloxy)benzonitrile DM2QD45 MI TTKPW01 DM2QD45 MN Androgen receptor messenger RNA (AR mRNA) DM2QD45 MT DTT DM2QD45 MA Inhibitor DM2QD45 RN 4-(Alkylthio)- and 4-(arylthio)-benzonitrile derivatives as androgen receptor antagonists for the topical suppression of sebum production. Bioorg Med Chem Lett. 2009 Mar 1;19(5):1310-3. DM2QD45 RU https://pubmed.ncbi.nlm.nih.gov/19201190 DMEGF58 DI DMEGF58 DMEGF58 DN 3-methoxy-4-(o-tolyloxy)benzonitrile DMEGF58 MI TTKPW01 DMEGF58 MN Androgen receptor messenger RNA (AR mRNA) DMEGF58 MT DTT DMEGF58 MA Inhibitor DMEGF58 RN 4-(Alkylthio)- and 4-(arylthio)-benzonitrile derivatives as androgen receptor antagonists for the topical suppression of sebum production. Bioorg Med Chem Lett. 2009 Mar 1;19(5):1310-3. DMEGF58 RU https://pubmed.ncbi.nlm.nih.gov/19201190 DMKUM4L DI DMKUM4L DMKUM4L DN 3-methoxy-4-(oxazol-5-yl)aniline DMKUM4L MI TTTB4UP DMKUM4L MN Inosine-5'-monophosphate dehydrogenase 2 (IMPDH2) DMKUM4L MT DTT DMKUM4L MA Inhibitor DMKUM4L RN Low molecular weight indole fragments as IMPDH inhibitors. Bioorg Med Chem Lett. 2006 May 1;16(9):2535-8. DMKUM4L RU https://pubmed.ncbi.nlm.nih.gov/16483769 DM37QE8 DI DM37QE8 DM37QE8 DN 3-methoxy-4-(p-tolyloxy)benzonitrile DM37QE8 MI TTKPW01 DM37QE8 MN Androgen receptor messenger RNA (AR mRNA) DM37QE8 MT DTT DM37QE8 MA Inhibitor DM37QE8 RN 4-(Alkylthio)- and 4-(arylthio)-benzonitrile derivatives as androgen receptor antagonists for the topical suppression of sebum production. Bioorg Med Chem Lett. 2009 Mar 1;19(5):1310-3. DM37QE8 RU https://pubmed.ncbi.nlm.nih.gov/19201190 DMG1T6H DI DMG1T6H DMG1T6H DN 3'-Methoxy-4'Hydroxyclomiphene DMG1T6H MI TTZAYWL DMG1T6H MN Estrogen receptor (ESR) DMG1T6H MT DTT DMG1T6H MA Inhibitor DMG1T6H RN Phenolic metabolites of clomiphene: [(E,Z)-2-[4-(1,2-diphenyl-2-chlorovinyl)phenoxy]ethyl]diethylamine. Preparation, electrophilicity, and effects ... J Med Chem. 1989 Jan;32(1):192-7. DMG1T6H RU https://pubmed.ncbi.nlm.nih.gov/2909731 DMG1T6H DI DMG1T6H DMG1T6H DN 3'-Methoxy-4'Hydroxyclomiphene DMG1T6H MI TTOM3J0 DMG1T6H MN Estrogen receptor beta (ESR2) DMG1T6H MT DTT DMG1T6H MA Inhibitor DMG1T6H RN Phenolic metabolites of clomiphene: [(E,Z)-2-[4-(1,2-diphenyl-2-chlorovinyl)phenoxy]ethyl]diethylamine. Preparation, electrophilicity, and effects ... J Med Chem. 1989 Jan;32(1):192-7. DMG1T6H RU https://pubmed.ncbi.nlm.nih.gov/2909731 DMAL1CP DI DMAL1CP DMAL1CP DN 3-methoxy-4-hydroxylonchocarpin DMAL1CP MI TTUMGNO DMAL1CP MN Ornithine decarboxylase (ODC1) DMAL1CP MT DTT DMAL1CP MA Inhibitor DMAL1CP RN New bioactive flavonoids and stilbenes in cub resin insecticide. J Nat Prod. 1999 Feb;62(2):205-10. DMAL1CP RU https://pubmed.ncbi.nlm.nih.gov/10075742 DMHYRES DI DMHYRES DMHYRES DN 3-methoxy-5-(1,5-naphthyridin-3-yl)benzonitrile DMHYRES MI TTHS256 DMHYRES MN Metabotropic glutamate receptor 5 (mGluR5) DMHYRES MT DTT DMHYRES MA Inhibitor DMHYRES RN Synthesis and SAR comparison of regioisomeric aryl naphthyridines as potent mGlu5 receptor antagonists. Bioorg Med Chem Lett. 2007 Dec 1;17(23):6525-8. DMHYRES RU https://pubmed.ncbi.nlm.nih.gov/17936624 DMKHJ8G DI DMKHJ8G DMKHJ8G DN 3-methoxy-5-(1,6-naphthyridin-7-yl)benzonitrile DMKHJ8G MI TTHS256 DMKHJ8G MN Metabotropic glutamate receptor 5 (mGluR5) DMKHJ8G MT DTT DMKHJ8G MA Inhibitor DMKHJ8G RN Synthesis and SAR comparison of regioisomeric aryl naphthyridines as potent mGlu5 receptor antagonists. Bioorg Med Chem Lett. 2007 Dec 1;17(23):6525-8. DMKHJ8G RU https://pubmed.ncbi.nlm.nih.gov/17936624 DMRMZLV DI DMRMZLV DMRMZLV DN 3-methoxy-5-(2-methylquinolin-7-yl)benzonitrile DMRMZLV MI TTHS256 DMRMZLV MN Metabotropic glutamate receptor 5 (mGluR5) DMRMZLV MT DTT DMRMZLV MA Inhibitor DMRMZLV RN Rational design of 7-arylquinolines as non-competitive metabotropic glutamate receptor subtype 5 antagonists. Bioorg Med Chem Lett. 2007 Aug 15;17(16):4415-8. DMRMZLV RU https://pubmed.ncbi.nlm.nih.gov/17590335 DMF2IW8 DI DMF2IW8 DMF2IW8 DN 3-methoxy-5-(6-methoxynaphthalen-2-yl)pyridine DMF2IW8 MI TTXV4FI DMF2IW8 MN Albendazole monooxygenase (CYP3A4) DMF2IW8 MT DTT DMF2IW8 MA Inhibitor DMF2IW8 RN Overcoming undesirable CYP1A2 inhibition of pyridylnaphthalene-type aldosterone synthase inhibitors: influence of heteroaryl derivatization on pote... J Med Chem. 2008 Aug 28;51(16):5064-74. DMF2IW8 RU https://pubmed.ncbi.nlm.nih.gov/18672861 DMF2IW8 DI DMF2IW8 DMF2IW8 DN 3-methoxy-5-(6-methoxynaphthalen-2-yl)pyridine DMF2IW8 MI TTIQUX7 DMF2IW8 MN Steroid 11-beta-hydroxylase (CYP11B1) DMF2IW8 MT DTT DMF2IW8 MA Inhibitor DMF2IW8 RN Overcoming undesirable CYP1A2 inhibition of pyridylnaphthalene-type aldosterone synthase inhibitors: influence of heteroaryl derivatization on pote... J Med Chem. 2008 Aug 28;51(16):5064-74. DMF2IW8 RU https://pubmed.ncbi.nlm.nih.gov/18672861 DMO2N56 DI DMO2N56 DMO2N56 DN 3-methoxy-9-aminomethyl-9,10-dihydroanthracene DMO2N56 MI TTJQOD7 DMO2N56 MN 5-HT 2A receptor (HTR2A) DMO2N56 MT DTT DMO2N56 MA Inhibitor DMO2N56 RN Methoxy-substituted 9-aminomethyl-9,10-dihydroanthracene (AMDA) derivatives exhibit differential binding affinities at the 5-HT(2A) receptor. Bioorg Med Chem Lett. 2008 Oct 1;18(19):5268-71. DMO2N56 RU https://pubmed.ncbi.nlm.nih.gov/18774714 DMTBX0D DI DMTBX0D DMTBX0D DN 3-Methoxy-9H-beta-carboline DMTBX0D MI TT1MPAY DMTBX0D MN GABA(A) receptor alpha-1 (GABRA1) DMTBX0D MT DTT DMTBX0D MA Inhibitor DMTBX0D RN Synthesis of novel 3-substituted beta-carbolines as benzodiazepine receptor ligands: probing the benzodiazepine receptor pharmacophore. J Med Chem. 1988 Sep;31(9):1854-61. DMTBX0D RU https://pubmed.ncbi.nlm.nih.gov/2842507 DMTBX0D DI DMTBX0D DMTBX0D DN 3-Methoxy-9H-beta-carboline DMTBX0D MI TTNJYV2 DMTBX0D MN Gamma-aminobutyric acid receptor (GAR) DMTBX0D MT DTT DMTBX0D MA Inhibitor DMTBX0D RN Synthesis of novel 3-substituted beta-carbolines as benzodiazepine receptor ligands: probing the benzodiazepine receptor pharmacophore. J Med Chem. 1988 Sep;31(9):1854-61. DMTBX0D RU https://pubmed.ncbi.nlm.nih.gov/2842507 DM245AB DI DM245AB DM245AB DN 3-Methoxybenzamide DM245AB MI TTVDSZ0 DM245AB MN Poly [ADP-ribose] polymerase 1 (PARP1) DM245AB MT DTT DM245AB MA Inhibitor DM245AB RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DM245AB RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMQMT1A DI DMQMT1A DMQMT1A DN 3-Methoxycarbonyl-2-methyl-9H-beta-carbolin-2-ium DMQMT1A MI TT1MPAY DMQMT1A MN GABA(A) receptor alpha-1 (GABRA1) DMQMT1A MT DTT DMQMT1A MA Inhibitor DMQMT1A RN N-2 methylated quaternary derivatives of beta-carboline-3-carboxylates inhibit acetylcholinesterase in vitroO, Bioorg. Med. Chem. Lett. 3(12):2831-2836 (1993). DMQMT1A RU http://www.sciencedirect.com/science/article/pii/S0960894X01807745 DMQMT1A DI DMQMT1A DMQMT1A DN 3-Methoxycarbonyl-2-methyl-9H-beta-carbolin-2-ium DMQMT1A MI TTNJYV2 DMQMT1A MN Gamma-aminobutyric acid receptor (GAR) DMQMT1A MT DTT DMQMT1A MA Inhibitor DMQMT1A RN N-2 methylated quaternary derivatives of beta-carboline-3-carboxylates inhibit acetylcholinesterase in vitroO, Bioorg. Med. Chem. Lett. 3(12):2831-2836 (1993). DMQMT1A RU http://www.sciencedirect.com/science/article/pii/S0960894X01807745 DMHVIK3 DI DMHVIK3 DMHVIK3 DN 3-methoxydesaminokynurenine DMHVIK3 MI TTWQM3J DMHVIK3 MN Kynureninase (KYNU) DMHVIK3 MT DTT DMHVIK3 MA Inhibitor DMHVIK3 RN Comparative inhibition by substrate analogues 3-methoxy- and 3-hydroxydesaminokynurenine and an improved 3 step purification of recombinant human kynureninase. BMC Biochem. 2003 Sep 24;4:13. DMHVIK3 RU https://pubmed.ncbi.nlm.nih.gov/14505498 DMWNO4D DI DMWNO4D DMWNO4D DN 3-Methoxyl-4'-amino-trans-stilbene DMWNO4D MI TTSZLWK DMWNO4D MN Aromatase (CYP19A1) DMWNO4D MT DTT DMWNO4D MA Inhibitor DMWNO4D RN Design, synthesis, and biological evaluation of resveratrol analogues as aromatase and quinone reductase 2 inhibitors for chemoprevention of cancer. Bioorg Med Chem. 2010 Jul 15;18(14):5352-66. DMWNO4D RU https://pubmed.ncbi.nlm.nih.gov/20558073 DMH1RX6 DI DMH1RX6 DMH1RX6 DN 3-Methoxymethyl-1,2,3,4-tetrahydro-isoquinoline DMH1RX6 MI TTWG9A4 DMH1RX6 MN Adrenergic receptor alpha-2A (ADRA2A) DMH1RX6 MT DTT DMH1RX6 MA Inhibitor DMH1RX6 RN 3,7-Disubstituted-1,2,3,4-tetrahydroisoquinolines display remarkable potency and selectivity as inhibitors of phenylethanolamine N-methyltransferas... J Med Chem. 1999 Jun 3;42(11):1982-90. DMH1RX6 RU https://pubmed.ncbi.nlm.nih.gov/10354406 DMH1RX6 DI DMH1RX6 DMH1RX6 DN 3-Methoxymethyl-1,2,3,4-tetrahydro-isoquinoline DMH1RX6 MI TTWM4TY DMH1RX6 MN Adrenergic receptor alpha-2B (ADRA2B) DMH1RX6 MT DTT DMH1RX6 MA Inhibitor DMH1RX6 RN 3,7-Disubstituted-1,2,3,4-tetrahydroisoquinolines display remarkable potency and selectivity as inhibitors of phenylethanolamine N-methyltransferas... J Med Chem. 1999 Jun 3;42(11):1982-90. DMH1RX6 RU https://pubmed.ncbi.nlm.nih.gov/10354406 DMH1RX6 DI DMH1RX6 DMH1RX6 DN 3-Methoxymethyl-1,2,3,4-tetrahydro-isoquinoline DMH1RX6 MI TT2NUT5 DMH1RX6 MN Adrenergic receptor alpha-2C (ADRA2C) DMH1RX6 MT DTT DMH1RX6 MA Inhibitor DMH1RX6 RN 3,7-Disubstituted-1,2,3,4-tetrahydroisoquinolines display remarkable potency and selectivity as inhibitors of phenylethanolamine N-methyltransferas... J Med Chem. 1999 Jun 3;42(11):1982-90. DMH1RX6 RU https://pubmed.ncbi.nlm.nih.gov/10354406 DMFEL39 DI DMFEL39 DMFEL39 DN 3-methoxy-N-(1,3,4-thiadiazol-2-yl)benzamide DMFEL39 MI TTSJ6Q4 DMFEL39 MN LOX-5 messenger RNA (ALOX5 mRNA) DMFEL39 MT DTT DMFEL39 MA Inhibitor DMFEL39 RN Identification of natural-product-derived inhibitors of 5-lipoxygenase activity by ligand-based virtual screening. J Med Chem. 2007 May 31;50(11):2640-6. DMFEL39 RU https://pubmed.ncbi.nlm.nih.gov/17461565 DM4WJX3 DI DM4WJX3 DM4WJX3 DN 3-methoxy-N-(4-methylthiazol-2-yl)benzamide DM4WJX3 MI TTSJ6Q4 DM4WJX3 MN LOX-5 messenger RNA (ALOX5 mRNA) DM4WJX3 MT DTT DM4WJX3 MA Inhibitor DM4WJX3 RN Identification of natural-product-derived inhibitors of 5-lipoxygenase activity by ligand-based virtual screening. J Med Chem. 2007 May 31;50(11):2640-6. DM4WJX3 RU https://pubmed.ncbi.nlm.nih.gov/17461565 DM4WJX3 DI DM4WJX3 DM4WJX3 DN 3-methoxy-N-(4-methylthiazol-2-yl)benzamide DM4WJX3 MI TTHS256 DM4WJX3 MN Metabotropic glutamate receptor 5 (mGluR5) DM4WJX3 MT DTT DM4WJX3 MA Inhibitor DM4WJX3 RN Design and synthesis of noncompetitive metabotropic glutamate receptor subtype 5 antagonists. Bioorg Med Chem Lett. 2006 Jul 1;16(13):3371-5. DM4WJX3 RU https://pubmed.ncbi.nlm.nih.gov/16678408 DMSFJNE DI DMSFJNE DMSFJNE DN 3-methoxy-N-(6-methylpyridin-2-yl)benzamide DMSFJNE MI TTHS256 DMSFJNE MN Metabotropic glutamate receptor 5 (mGluR5) DMSFJNE MT DTT DMSFJNE MA Inhibitor DMSFJNE RN Design and synthesis of noncompetitive metabotropic glutamate receptor subtype 5 antagonists. Bioorg Med Chem Lett. 2006 Jul 1;16(13):3371-5. DMSFJNE RU https://pubmed.ncbi.nlm.nih.gov/16678408 DMZ9MQ5 DI DMZ9MQ5 DMZ9MQ5 DN 3-methoxy-N',2-diphenylquinoline-4-carbohydrazide DMZ9MQ5 MI TTBPGLU DMZ9MQ5 MN Neuromedin-K receptor (TACR3) DMZ9MQ5 MT DTT DMZ9MQ5 MA Inhibitor DMZ9MQ5 RN N',2-diphenylquinoline-4-carbohydrazide based NK3 receptor antagonists. Bioorg Med Chem Lett. 2006 Nov 15;16(22):5748-51. DMZ9MQ5 RU https://pubmed.ncbi.nlm.nih.gov/16950620 DMKHVGJ DI DMKHVGJ DMKHVGJ DN 3-methoxyphenyl 10H-phenothiazine-10-carboxylate DMKHVGJ MI TTEB0GD DMKHVGJ MN Cholinesterase (BCHE) DMKHVGJ MT DTT DMKHVGJ MA Inhibitor DMKHVGJ RN Carbamates with differential mechanism of inhibition toward acetylcholinesterase and butyrylcholinesterase. J Med Chem. 2008 Jul 24;51(14):4200-12. DMKHVGJ RU https://pubmed.ncbi.nlm.nih.gov/18570368 DMHJTLW DI DMHJTLW DMHJTLW DN 3-methoxyphenylboronic acid DMHJTLW MI TTDP1UC DMHJTLW MN Fatty acid amide hydrolase (FAAH) DMHJTLW MT DTT DMHJTLW MA Inhibitor DMHJTLW RN Discovery of boronic acids as novel and potent inhibitors of fatty acid amide hydrolase. J Med Chem. 2008 Nov 27;51(22):7057-60. DMHJTLW RU https://pubmed.ncbi.nlm.nih.gov/18983140 DMCOH46 DI DMCOH46 DMCOH46 DN 3-Methyl-[1,4]thiazepan-(5E)-ylideneamine DMCOH46 MI TTZUFI5 DMCOH46 MN Nitric-oxide synthase brain (NOS1) DMCOH46 MT DTT DMCOH46 MA Inhibitor DMCOH46 RN Synthesis of analogs of (1,4)-3- and 5-imino oxazepane, thiazepane, and diazepane as inhibitors of nitric oxide synthases. Bioorg Med Chem Lett. 2004 Dec 6;14(23):5907-11. DMCOH46 RU https://pubmed.ncbi.nlm.nih.gov/15501067 DMCOH46 DI DMCOH46 DMCOH46 DN 3-Methyl-[1,4]thiazepan-(5E)-ylideneamine DMCOH46 MI TTCM4B3 DMCOH46 MN Nitric-oxide synthase endothelial (NOS3) DMCOH46 MT DTT DMCOH46 MA Inhibitor DMCOH46 RN Synthesis of analogs of (1,4)-3- and 5-imino oxazepane, thiazepane, and diazepane as inhibitors of nitric oxide synthases. Bioorg Med Chem Lett. 2004 Dec 6;14(23):5907-11. DMCOH46 RU https://pubmed.ncbi.nlm.nih.gov/15501067 DMCOH46 DI DMCOH46 DMCOH46 DN 3-Methyl-[1,4]thiazepan-(5E)-ylideneamine DMCOH46 MI TTF10I9 DMCOH46 MN Nitric-oxide synthase inducible (NOS2) DMCOH46 MT DTT DMCOH46 MA Inhibitor DMCOH46 RN Synthesis of analogs of (1,4)-3- and 5-imino oxazepane, thiazepane, and diazepane as inhibitors of nitric oxide synthases. Bioorg Med Chem Lett. 2004 Dec 6;14(23):5907-11. DMCOH46 RU https://pubmed.ncbi.nlm.nih.gov/15501067 DMIWQ7G DI DMIWQ7G DMIWQ7G DN 3-Methyl-1,2,3,4-tetrahydro-isoquinoline DMIWQ7G MI TTWG9A4 DMIWQ7G MN Adrenergic receptor alpha-2A (ADRA2A) DMIWQ7G MT DTT DMIWQ7G MA Inhibitor DMIWQ7G RN Effect of ring size or an additional heteroatom on the potency and selectivity of bicyclic benzylamine-type inhibitors of phenylethanolamine N-meth... J Med Chem. 1996 Aug 30;39(18):3539-46. DMIWQ7G RU https://pubmed.ncbi.nlm.nih.gov/8784452 DMIWQ7G DI DMIWQ7G DMIWQ7G DN 3-Methyl-1,2,3,4-tetrahydro-isoquinoline DMIWQ7G MI TTWM4TY DMIWQ7G MN Adrenergic receptor alpha-2B (ADRA2B) DMIWQ7G MT DTT DMIWQ7G MA Inhibitor DMIWQ7G RN Effect of ring size or an additional heteroatom on the potency and selectivity of bicyclic benzylamine-type inhibitors of phenylethanolamine N-meth... J Med Chem. 1996 Aug 30;39(18):3539-46. DMIWQ7G RU https://pubmed.ncbi.nlm.nih.gov/8784452 DMIWQ7G DI DMIWQ7G DMIWQ7G DN 3-Methyl-1,2,3,4-tetrahydro-isoquinoline DMIWQ7G MI TT2NUT5 DMIWQ7G MN Adrenergic receptor alpha-2C (ADRA2C) DMIWQ7G MT DTT DMIWQ7G MA Inhibitor DMIWQ7G RN Effect of ring size or an additional heteroatom on the potency and selectivity of bicyclic benzylamine-type inhibitors of phenylethanolamine N-meth... J Med Chem. 1996 Aug 30;39(18):3539-46. DMIWQ7G RU https://pubmed.ncbi.nlm.nih.gov/8784452 DMKOX0N DI DMKOX0N DMKOX0N DN 3-methyl-1H-thieno[2,3-c]pyrazole-5-carboxamide DMKOX0N MI TTUTJGQ DMKOX0N MN Vascular endothelial growth factor receptor 2 (KDR) DMKOX0N MT DTT DMKOX0N MA Inhibitor DMKOX0N RN Scaffold oriented synthesis. Part 1: Design, preparation, and biological evaluation of thienopyrazoles as kinase inhibitors. Bioorg Med Chem Lett. 2006 Jan 1;16(1):96-9. DMKOX0N RU https://pubmed.ncbi.nlm.nih.gov/16216502 DMKYPUW DI DMKYPUW DMKYPUW DN 3-Methyl-1-phenethyl-3,7-dihydro-purine-2,6-dione DMKYPUW MI TTNE7KG DMKYPUW MN Adenosine A2b receptor (ADORA2B) DMKYPUW MT DTT DMKYPUW MA Inhibitor DMKYPUW RN Structure-activity relationships at human and rat A2B adenosine receptors of xanthine derivatives substituted at the 1-, 3-, 7-, and 8-positions. J Med Chem. 2002 May 23;45(11):2131-8. DMKYPUW RU https://pubmed.ncbi.nlm.nih.gov/12014951 DMKYPUW DI DMKYPUW DMKYPUW DN 3-Methyl-1-phenethyl-3,7-dihydro-purine-2,6-dione DMKYPUW MI TTJFY5U DMKYPUW MN Adenosine A3 receptor (ADORA3) DMKYPUW MT DTT DMKYPUW MA Inhibitor DMKYPUW RN Structure-activity relationships at human and rat A2B adenosine receptors of xanthine derivatives substituted at the 1-, 3-, 7-, and 8-positions. J Med Chem. 2002 May 23;45(11):2131-8. DMKYPUW RU https://pubmed.ncbi.nlm.nih.gov/12014951 DMTM6B0 DI DMTM6B0 DMTM6B0 DN 3-Methyl-1-phenyl-1H-chromeno[4,3-c]pyrazol-4-one DMTM6B0 MI TT1MPAY DMTM6B0 MN GABA(A) receptor alpha-1 (GABRA1) DMTM6B0 MT DTT DMTM6B0 MA Inhibitor DMTM6B0 RN Synthesis, binding studies, and structure-activity relationships of 1-aryl-and 2-aryl[1]benzopyranopyrazol-4-ones, central benzodiazepine receptor ... J Med Chem. 1988 Jan;31(1):1-3. DMTM6B0 RU https://pubmed.ncbi.nlm.nih.gov/2826782 DMTM6B0 DI DMTM6B0 DMTM6B0 DN 3-Methyl-1-phenyl-1H-chromeno[4,3-c]pyrazol-4-one DMTM6B0 MI TT06RH5 DMTM6B0 MN GABA(A) receptor gamma-2 (GABRG2) DMTM6B0 MT DTT DMTM6B0 MA Inhibitor DMTM6B0 RN Synthesis, binding studies, and structure-activity relationships of 1-aryl-and 2-aryl[1]benzopyranopyrazol-4-ones, central benzodiazepine receptor ... J Med Chem. 1988 Jan;31(1):1-3. DMTM6B0 RU https://pubmed.ncbi.nlm.nih.gov/2826782 DMTM6B0 DI DMTM6B0 DMTM6B0 DN 3-Methyl-1-phenyl-1H-chromeno[4,3-c]pyrazol-4-one DMTM6B0 MI TTNJYV2 DMTM6B0 MN Gamma-aminobutyric acid receptor (GAR) DMTM6B0 MT DTT DMTM6B0 MA Inhibitor DMTM6B0 RN Synthesis, binding studies, and structure-activity relationships of 1-aryl-and 2-aryl[1]benzopyranopyrazol-4-ones, central benzodiazepine receptor ... J Med Chem. 1988 Jan;31(1):1-3. DMTM6B0 RU https://pubmed.ncbi.nlm.nih.gov/2826782 DMHVNQM DI DMHVNQM DMHVNQM DN 3-methyl-2(1H)-thioxo-4(3H)-quinazolinone DMHVNQM MI TT3WG5C DMHVNQM MN Monoamine oxidase type A (MAO-A) DMHVNQM MT DTT DMHVNQM MA Inhibitor DMHVNQM RN New pyrazoline bearing 4(3H)-quinazolinone inhibitors of monoamine oxidase: synthesis, biological evaluation, and structural determinants of MAO-A ... Bioorg Med Chem. 2009 Jan 15;17(2):675-89. DMHVNQM RU https://pubmed.ncbi.nlm.nih.gov/19091581 DMFC0H5 DI DMFC0H5 DMFC0H5 DN 3-Methyl-2H-benzo[f]quinazolin-1-one DMFC0H5 MI TTU6BFZ DMFC0H5 MN Candida Thymidylate synthase (Candi TMP1) DMFC0H5 MT DTT DMFC0H5 MA Inhibitor DMFC0H5 RN Benzoquinazoline inhibitors of thymidylate synthase: enzyme inhibitory activity and cytotoxicity of some sulfonamidobenzoylglutamate and related de... J Med Chem. 1993 Oct 29;36(22):3464-71. DMFC0H5 RU https://pubmed.ncbi.nlm.nih.gov/8230138 DMKWAV6 DI DMKWAV6 DMKWAV6 DN 3-methyl-2-morpholino-1,1-diphenylbutan-1-ol DMKWAV6 MI TTW0CMT DMKWAV6 MN Voltage-gated potassium channel Kv1.5 (KCNA5) DMKWAV6 MT DTT DMKWAV6 MA Inhibitor DMKWAV6 RN Discovery of triarylethanolamine inhibitors of the Kv1.5 potassium channel. Bioorg Med Chem Lett. 2010 Apr 15;20(8):2493-6. DMKWAV6 RU https://pubmed.ncbi.nlm.nih.gov/20304642 DM870UV DI DM870UV DM870UV DN 3-Methyl-2-phenyl-2H-chromeno[4,3-c]pyrazol-4-one DM870UV MI TT1MPAY DM870UV MN GABA(A) receptor alpha-1 (GABRA1) DM870UV MT DTT DM870UV MA Inhibitor DM870UV RN Synthesis, binding studies, and structure-activity relationships of 1-aryl-and 2-aryl[1]benzopyranopyrazol-4-ones, central benzodiazepine receptor ... J Med Chem. 1988 Jan;31(1):1-3. DM870UV RU https://pubmed.ncbi.nlm.nih.gov/2826782 DM870UV DI DM870UV DM870UV DN 3-Methyl-2-phenyl-2H-chromeno[4,3-c]pyrazol-4-one DM870UV MI TT06RH5 DM870UV MN GABA(A) receptor gamma-2 (GABRG2) DM870UV MT DTT DM870UV MA Inhibitor DM870UV RN Synthesis, binding studies, and structure-activity relationships of 1-aryl-and 2-aryl[1]benzopyranopyrazol-4-ones, central benzodiazepine receptor ... J Med Chem. 1988 Jan;31(1):1-3. DM870UV RU https://pubmed.ncbi.nlm.nih.gov/2826782 DM870UV DI DM870UV DM870UV DN 3-Methyl-2-phenyl-2H-chromeno[4,3-c]pyrazol-4-one DM870UV MI TTNJYV2 DM870UV MN Gamma-aminobutyric acid receptor (GAR) DM870UV MT DTT DM870UV MA Inhibitor DM870UV RN Synthesis, binding studies, and structure-activity relationships of 1-aryl-and 2-aryl[1]benzopyranopyrazol-4-ones, central benzodiazepine receptor ... J Med Chem. 1988 Jan;31(1):1-3. DM870UV RU https://pubmed.ncbi.nlm.nih.gov/2826782 DM0WVTF DI DM0WVTF DM0WVTF DN 3-Methyl-4-phenylbut-3-en-2-one oxime DM0WVTF MI TTELV3W DM0WVTF MN Transformation-sensitive protein p120 (TRPA1) DM0WVTF MT DTT DM0WVTF MA Inhibitor DM0WVTF RN Oxime derivatives related to AP18: Agonists and antagonists of the TRPA1 receptor. Bioorg Med Chem Lett. 2010 Jan 1;20(1):276-9. DM0WVTF RU https://pubmed.ncbi.nlm.nih.gov/19945872 DMM3RNV DI DMM3RNV DMM3RNV DN 3-methyl-5-(2-methylquinolin-7-yl)benzonitrile DMM3RNV MI TTHS256 DMM3RNV MN Metabotropic glutamate receptor 5 (mGluR5) DMM3RNV MT DTT DMM3RNV MA Inhibitor DMM3RNV RN Rational design of 7-arylquinolines as non-competitive metabotropic glutamate receptor subtype 5 antagonists. Bioorg Med Chem Lett. 2007 Aug 15;17(16):4415-8. DMM3RNV RU https://pubmed.ncbi.nlm.nih.gov/17590335 DM3BL45 DI DM3BL45 DM3BL45 DN 3-methyl-6-(trifluoromethyl)-9H-carbazole DM3BL45 MI TTBGTCW DM3BL45 MN Kinesin spindle messenger RNA (KIF11 mRNA) DM3BL45 MT DTT DM3BL45 MA Inhibitor DM3BL45 RN Kinesin spindle protein (KSP) inhibitors with 2,3-fused indole scaffolds. J Med Chem. 2010 Jul 8;53(13):5054-8. DM3BL45 RU https://pubmed.ncbi.nlm.nih.gov/20521839 DMZY6VX DI DMZY6VX DMZY6VX DN 3-Methyl-7-nitro-1,2,3,4-tetrahydro-isoquinoline DMZY6VX MI TTWG9A4 DMZY6VX MN Adrenergic receptor alpha-2A (ADRA2A) DMZY6VX MT DTT DMZY6VX MA Inhibitor DMZY6VX RN Exploring the active site of phenylethanolamine N-methyltransferase with 3-hydroxyethyl- and 3-hydroxypropyl-7-substituted-1,2,3,4-tetrahydroisoqui... Bioorg Med Chem Lett. 2005 Feb 15;15(4):1143-7. DMZY6VX RU https://pubmed.ncbi.nlm.nih.gov/15686930 DME81U3 DI DME81U3 DME81U3 DN 3-Methyl-7-pyrrolidin-1-yl-hept-5-yn-2-one DME81U3 MI TTZ9SOR DME81U3 MN Muscarinic acetylcholine receptor M1 (CHRM1) DME81U3 MT DTT DME81U3 MA Inhibitor DME81U3 RN Cholinergic agents: aldehyde, ketone, and oxime analogues of the muscarinic agonist UH5, Bioorg. Med. Chem. Lett. 2(8):803-808 (1992). DME81U3 RU http://www.sciencedirect.com/science/article/pii/S0960894X00805351 DME81U3 DI DME81U3 DME81U3 DN 3-Methyl-7-pyrrolidin-1-yl-hept-5-yn-2-one DME81U3 MI TTYEG6Q DME81U3 MN Muscarinic acetylcholine receptor M2 (CHRM2) DME81U3 MT DTT DME81U3 MA Inhibitor DME81U3 RN Cholinergic agents: aldehyde, ketone, and oxime analogues of the muscarinic agonist UH5, Bioorg. Med. Chem. Lett. 2(8):803-808 (1992). DME81U3 RU http://www.sciencedirect.com/science/article/pii/S0960894X00805351 DME81U3 DI DME81U3 DME81U3 DN 3-Methyl-7-pyrrolidin-1-yl-hept-5-yn-2-one DME81U3 MI TTQ13Z5 DME81U3 MN Muscarinic acetylcholine receptor M3 (CHRM3) DME81U3 MT DTT DME81U3 MA Inhibitor DME81U3 RN Cholinergic agents: aldehyde, ketone, and oxime analogues of the muscarinic agonist UH5, Bioorg. Med. Chem. Lett. 2(8):803-808 (1992). DME81U3 RU http://www.sciencedirect.com/science/article/pii/S0960894X00805351 DME81U3 DI DME81U3 DME81U3 DN 3-Methyl-7-pyrrolidin-1-yl-hept-5-yn-2-one DME81U3 MI TTQ3JTF DME81U3 MN Muscarinic acetylcholine receptor M4 (CHRM4) DME81U3 MT DTT DME81U3 MA Inhibitor DME81U3 RN Cholinergic agents: aldehyde, ketone, and oxime analogues of the muscarinic agonist UH5, Bioorg. Med. Chem. Lett. 2(8):803-808 (1992). DME81U3 RU http://www.sciencedirect.com/science/article/pii/S0960894X00805351 DME81U3 DI DME81U3 DME81U3 DN 3-Methyl-7-pyrrolidin-1-yl-hept-5-yn-2-one DME81U3 MI TTH18TF DME81U3 MN Muscarinic acetylcholine receptor M5 (CHRM5) DME81U3 MT DTT DME81U3 MA Inhibitor DME81U3 RN Cholinergic agents: aldehyde, ketone, and oxime analogues of the muscarinic agonist UH5, Bioorg. Med. Chem. Lett. 2(8):803-808 (1992). DME81U3 RU http://www.sciencedirect.com/science/article/pii/S0960894X00805351 DMEJKZN DI DMEJKZN DMEJKZN DN 3-Methyl-9H-beta-carboline DMEJKZN MI TT1MPAY DMEJKZN MN GABA(A) receptor alpha-1 (GABRA1) DMEJKZN MT DTT DMEJKZN MA Inhibitor DMEJKZN RN Four amino acid exchanges convert a diazepam-insensitive, inverse agonist-preferring GABAA receptor into a diazepam-preferring GABAA receptor. J Med Chem. 1994 Dec 23;37(26):4576-80. DMEJKZN RU https://pubmed.ncbi.nlm.nih.gov/7799410 DMEJKZN DI DMEJKZN DMEJKZN DN 3-Methyl-9H-beta-carboline DMEJKZN MI TTZA1NY DMEJKZN MN GABA(A) receptor beta-2 (GABRB2) DMEJKZN MT DTT DMEJKZN MA Inhibitor DMEJKZN RN Four amino acid exchanges convert a diazepam-insensitive, inverse agonist-preferring GABAA receptor into a diazepam-preferring GABAA receptor. J Med Chem. 1994 Dec 23;37(26):4576-80. DMEJKZN RU https://pubmed.ncbi.nlm.nih.gov/7799410 DMEJKZN DI DMEJKZN DMEJKZN DN 3-Methyl-9H-beta-carboline DMEJKZN MI TT06RH5 DMEJKZN MN GABA(A) receptor gamma-2 (GABRG2) DMEJKZN MT DTT DMEJKZN MA Inhibitor DMEJKZN RN Four amino acid exchanges convert a diazepam-insensitive, inverse agonist-preferring GABAA receptor into a diazepam-preferring GABAA receptor. J Med Chem. 1994 Dec 23;37(26):4576-80. DMEJKZN RU https://pubmed.ncbi.nlm.nih.gov/7799410 DMEJKZN DI DMEJKZN DMEJKZN DN 3-Methyl-9H-beta-carboline DMEJKZN MI TTNJYV2 DMEJKZN MN Gamma-aminobutyric acid receptor (GAR) DMEJKZN MT DTT DMEJKZN MA Inhibitor DMEJKZN RN Four amino acid exchanges convert a diazepam-insensitive, inverse agonist-preferring GABAA receptor into a diazepam-preferring GABAA receptor. J Med Chem. 1994 Dec 23;37(26):4576-80. DMEJKZN RU https://pubmed.ncbi.nlm.nih.gov/7799410 DMX71N9 DI DMX71N9 DMX71N9 DN 3-Methylfentanyl DMX71N9 MI TT27RFC DMX71N9 MN Opioid receptor delta (OPRD1) DMX71N9 MT DTT DMX71N9 MA Agonist DMX71N9 RN Subramanian G, Paterlini MG, Portoghese PS, Ferguson DM: Molecular docking reveals a novel binding site model for fentanyl at the mu-opioid receptor. J Med Chem. 2000 Feb 10;43(3):381-91. DMX71N9 RU https://pubmed.ncbi.nlm.nih.gov/10669565 DMX71N9 DI DMX71N9 DMX71N9 DN 3-Methylfentanyl DMX71N9 MI TTQW87Y DMX71N9 MN Opioid receptor kappa (OPRK1) DMX71N9 MT DTT DMX71N9 MA Agonist DMX71N9 RN Subramanian G, Paterlini MG, Portoghese PS, Ferguson DM: Molecular docking reveals a novel binding site model for fentanyl at the mu-opioid receptor. J Med Chem. 2000 Feb 10;43(3):381-91. DMX71N9 RU https://pubmed.ncbi.nlm.nih.gov/10669565 DMX71N9 DI DMX71N9 DMX71N9 DN 3-Methylfentanyl DMX71N9 MI TTKWM86 DMX71N9 MN Opioid receptor mu (MOP) DMX71N9 MT DTT DMX71N9 MA Agonist DMX71N9 RN Subramanian G, Paterlini MG, Portoghese PS, Ferguson DM: Molecular docking reveals a novel binding site model for fentanyl at the mu-opioid receptor. J Med Chem. 2000 Feb 10;43(3):381-91. DMX71N9 RU https://pubmed.ncbi.nlm.nih.gov/10669565 DMRNMKG DI DMRNMKG DMRNMKG DN 3-methyl-N-(6-methylpyridin-2-yl)benzamide DMRNMKG MI TTHS256 DMRNMKG MN Metabotropic glutamate receptor 5 (mGluR5) DMRNMKG MT DTT DMRNMKG MA Inhibitor DMRNMKG RN Design and synthesis of noncompetitive metabotropic glutamate receptor subtype 5 antagonists. Bioorg Med Chem Lett. 2006 Jul 1;16(13):3371-5. DMRNMKG RU https://pubmed.ncbi.nlm.nih.gov/16678408 DMQOI5X DI DMQOI5X DMQOI5X DN 3-Methylphenylalanine DMQOI5X MI TTF2LRI DMQOI5X MN Cathepsin B (CTSB) DMQOI5X MT DTT DMQOI5X MA Inhibitor DMQOI5X RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMQOI5X RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMF3JHM DI DMF3JHM DMF3JHM DN 3-Methylpyridine DMF3JHM MI TTHY57M DMF3JHM MN Matrix metalloproteinase-13 (MMP-13) DMF3JHM MT DTT DMF3JHM MA Inhibitor DMF3JHM RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMF3JHM RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMF3JHM DI DMF3JHM DMF3JHM DN 3-Methylpyridine DMF3JHM MI TTUZ2L5 DMF3JHM MN Matrix metalloproteinase-3 (MMP-3) DMF3JHM MT DTT DMF3JHM MA Inhibitor DMF3JHM RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMF3JHM RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMHVUF8 DI DMHVUF8 DMHVUF8 DN 3-Methyl-pyrrolidin-(2Z)-ylideneamine DMHVUF8 MI TTZUFI5 DMHVUF8 MN Nitric-oxide synthase brain (NOS1) DMHVUF8 MT DTT DMHVUF8 MA Inhibitor DMHVUF8 RN Evaluation of pyrrolidin-2-imines and 1,3-thiazolidin-2-imines as inhibitors of nitric oxide synthase. Bioorg Med Chem Lett. 2004 Sep 6;14(17):4539-44. DMHVUF8 RU https://pubmed.ncbi.nlm.nih.gov/15357988 DMHVUF8 DI DMHVUF8 DMHVUF8 DN 3-Methyl-pyrrolidin-(2Z)-ylideneamine DMHVUF8 MI TTCM4B3 DMHVUF8 MN Nitric-oxide synthase endothelial (NOS3) DMHVUF8 MT DTT DMHVUF8 MA Inhibitor DMHVUF8 RN Evaluation of pyrrolidin-2-imines and 1,3-thiazolidin-2-imines as inhibitors of nitric oxide synthase. Bioorg Med Chem Lett. 2004 Sep 6;14(17):4539-44. DMHVUF8 RU https://pubmed.ncbi.nlm.nih.gov/15357988 DMHVUF8 DI DMHVUF8 DMHVUF8 DN 3-Methyl-pyrrolidin-(2Z)-ylideneamine DMHVUF8 MI TTF10I9 DMHVUF8 MN Nitric-oxide synthase inducible (NOS2) DMHVUF8 MT DTT DMHVUF8 MA Inhibitor DMHVUF8 RN Evaluation of pyrrolidin-2-imines and 1,3-thiazolidin-2-imines as inhibitors of nitric oxide synthase. Bioorg Med Chem Lett. 2004 Sep 6;14(17):4539-44. DMHVUF8 RU https://pubmed.ncbi.nlm.nih.gov/15357988 DMQZULR DI DMQZULR DMQZULR DN 3-Methylquinoline-8-carboxamide DMQZULR MI TTVDSZ0 DMQZULR MN Poly [ADP-ribose] polymerase 1 (PARP1) DMQZULR MT DTT DMQZULR MA Inhibitor DMQZULR RN Design, synthesis, and evaluation in vitro of quinoline-8-carboxamides, a new class of poly(adenosine-diphosphate-ribose)polymerase-1 (PARP-1) inhi... J Med Chem. 2009 Feb 12;52(3):868-77. DMQZULR RU https://pubmed.ncbi.nlm.nih.gov/19117416 DMC153X DI DMC153X DMC153X DN 3-Methylthiofentanyl DMC153X MI TT27RFC DMC153X MN Opioid receptor delta (OPRD1) DMC153X MT DTT DMC153X MA Agonist DMC153X RN You HJ, Colpaert FC, Arendt-Nielsen L: The novel analgesic and high-efficacy 5-HT1A receptor agonist F 13640 inhibits nociceptive responses, wind-up, and after-discharges in spinal neurons and withdrawal reflexes. Exp Neurol. 2005 Jan;191(1):174-83. DMC153X RU https://pubmed.ncbi.nlm.nih.gov/15589524 DMC153X DI DMC153X DMC153X DN 3-Methylthiofentanyl DMC153X MI TTQW87Y DMC153X MN Opioid receptor kappa (OPRK1) DMC153X MT DTT DMC153X MA Agonist DMC153X RN You HJ, Colpaert FC, Arendt-Nielsen L: The novel analgesic and high-efficacy 5-HT1A receptor agonist F 13640 inhibits nociceptive responses, wind-up, and after-discharges in spinal neurons and withdrawal reflexes. Exp Neurol. 2005 Jan;191(1):174-83. DMC153X RU https://pubmed.ncbi.nlm.nih.gov/15589524 DMC153X DI DMC153X DMC153X DN 3-Methylthiofentanyl DMC153X MI TTKWM86 DMC153X MN Opioid receptor mu (MOP) DMC153X MT DTT DMC153X MA Agonist DMC153X RN You HJ, Colpaert FC, Arendt-Nielsen L: The novel analgesic and high-efficacy 5-HT1A receptor agonist F 13640 inhibits nociceptive responses, wind-up, and after-discharges in spinal neurons and withdrawal reflexes. Exp Neurol. 2005 Jan;191(1):174-83. DMC153X RU https://pubmed.ncbi.nlm.nih.gov/15589524 DM0YS25 DI DM0YS25 DM0YS25 DN 3-Morpholin-4-ylmethyl-5H-phenanthridin-6-one DM0YS25 MI TTVDSZ0 DM0YS25 MN Poly [ADP-ribose] polymerase 1 (PARP1) DM0YS25 MT DTT DM0YS25 MA Inhibitor DM0YS25 RN 4-Phenyl-1,2,3,6-tetrahydropyridine, an excellent fragment to improve the potency of PARP-1 inhibitors. Bioorg Med Chem Lett. 2005 Oct 1;15(19):4221-5. DM0YS25 RU https://pubmed.ncbi.nlm.nih.gov/16098744 DMGWH0E DI DMGWH0E DMGWH0E DN 3-morpholino-1H-benzo[f]chromen-1-one DMGWH0E MI TTK3PY9 DMGWH0E MN DNA-dependent protein kinase catalytic (PRKDC) DMGWH0E MT DTT DMGWH0E MA Inhibitor DMGWH0E RN Pyranone, thiopyranone, and pyridone inhibitors of phosphatidylinositol 3-kinase related kinases. Structure-activity relationships for DNA-dependen... J Med Chem. 2007 Apr 19;50(8):1958-72. DMGWH0E RU https://pubmed.ncbi.nlm.nih.gov/17371003 DMCDLG4 DI DMCDLG4 DMCDLG4 DN 3-MPPTS DMCDLG4 MI TTXJ47W DMCDLG4 MN Metabotropic glutamate receptor 2 (mGluR2) DMCDLG4 MT DTT DMCDLG4 MA Modulator (allosteric modulator) DMCDLG4 RN Metabotropic glutamate 2 receptor potentiators: receptor modulation, frequency-dependent synaptic activity, and efficacy in preclinical anxiety and... Psychopharmacology (Berl). 2005 Apr;179(1):271-83. DMCDLG4 RU https://pubmed.ncbi.nlm.nih.gov/15717213 DMMFA4N DI DMMFA4N DMMFA4N DN 3-m-tolyl-1,5-naphthyridine DMMFA4N MI TTHS256 DMMFA4N MN Metabotropic glutamate receptor 5 (mGluR5) DMMFA4N MT DTT DMMFA4N MA Inhibitor DMMFA4N RN Synthesis and SAR comparison of regioisomeric aryl naphthyridines as potent mGlu5 receptor antagonists. Bioorg Med Chem Lett. 2007 Dec 1;17(23):6525-8. DMMFA4N RU https://pubmed.ncbi.nlm.nih.gov/17936624 DMNZI9R DI DMNZI9R DMNZI9R DN 3-Naphthalen-1-yl-1-propyl-pyrrolidine DMNZI9R MI TTSQIFT DMNZI9R MN 5-HT 1A receptor (HTR1A) DMNZI9R MT DTT DMNZI9R MA Inhibitor DMNZI9R RN Regioselective synthesis of 3-aryl substituted pyrrolidines via palladium catalyzed arylation: pharmacological evaluation for central dopaminergic and serotonergic activity, Bioorg. Med. Chem. Lett. 7(3):241-246 (1997). DMNZI9R RU http://www.sciencedirect.com/science/article/pii/S0960894X9600618X DMNZI9R DI DMNZI9R DMNZI9R DN 3-Naphthalen-1-yl-1-propyl-pyrrolidine DMNZI9R MI TTJQOD7 DMNZI9R MN 5-HT 2A receptor (HTR2A) DMNZI9R MT DTT DMNZI9R MA Inhibitor DMNZI9R RN Regioselective synthesis of 3-aryl substituted pyrrolidines via palladium catalyzed arylation: pharmacological evaluation for central dopaminergic and serotonergic activity, Bioorg. Med. Chem. Lett. 7(3):241-246 (1997). DMNZI9R RU http://www.sciencedirect.com/science/article/pii/S0960894X9600618X DMNZI9R DI DMNZI9R DMNZI9R DN 3-Naphthalen-1-yl-1-propyl-pyrrolidine DMNZI9R MI TTEX248 DMNZI9R MN Dopamine D2 receptor (D2R) DMNZI9R MT DTT DMNZI9R MA Inhibitor DMNZI9R RN Regioselective synthesis of 3-aryl substituted pyrrolidines via palladium catalyzed arylation: pharmacological evaluation for central dopaminergic and serotonergic activity, Bioorg. Med. Chem. Lett. 7(3):241-246 (1997). DMNZI9R RU http://www.sciencedirect.com/science/article/pii/S0960894X9600618X DMCW7F5 DI DMCW7F5 DMCW7F5 DN 3-Naphthalen-1-yl-pyrrolidine DMCW7F5 MI TTSQIFT DMCW7F5 MN 5-HT 1A receptor (HTR1A) DMCW7F5 MT DTT DMCW7F5 MA Inhibitor DMCW7F5 RN Regioselective synthesis of 3-aryl substituted pyrrolidines via palladium catalyzed arylation: pharmacological evaluation for central dopaminergic and serotonergic activity, Bioorg. Med. Chem. Lett. 7(3):241-246 (1997). DMCW7F5 RU http://www.sciencedirect.com/science/article/pii/S0960894X9600618X DMCW7F5 DI DMCW7F5 DMCW7F5 DN 3-Naphthalen-1-yl-pyrrolidine DMCW7F5 MI TTJQOD7 DMCW7F5 MN 5-HT 2A receptor (HTR2A) DMCW7F5 MT DTT DMCW7F5 MA Inhibitor DMCW7F5 RN Regioselective synthesis of 3-aryl substituted pyrrolidines via palladium catalyzed arylation: pharmacological evaluation for central dopaminergic and serotonergic activity, Bioorg. Med. Chem. Lett. 7(3):241-246 (1997). DMCW7F5 RU http://www.sciencedirect.com/science/article/pii/S0960894X9600618X DMCW7F5 DI DMCW7F5 DMCW7F5 DN 3-Naphthalen-1-yl-pyrrolidine DMCW7F5 MI TTEX248 DMCW7F5 MN Dopamine D2 receptor (D2R) DMCW7F5 MT DTT DMCW7F5 MA Inhibitor DMCW7F5 RN Regioselective synthesis of 3-aryl substituted pyrrolidines via palladium catalyzed arylation: pharmacological evaluation for central dopaminergic and serotonergic activity, Bioorg. Med. Chem. Lett. 7(3):241-246 (1997). DMCW7F5 RU http://www.sciencedirect.com/science/article/pii/S0960894X9600618X DMZRNOT DI DMZRNOT DMZRNOT DN 3-Nitro-4'-nitro-trans-stilbene DMZRNOT MI TTSZLWK DMZRNOT MN Aromatase (CYP19A1) DMZRNOT MT DTT DMZRNOT MA Inhibitor DMZRNOT RN Design, synthesis, and biological evaluation of resveratrol analogues as aromatase and quinone reductase 2 inhibitors for chemoprevention of cancer. Bioorg Med Chem. 2010 Jul 15;18(14):5352-66. DMZRNOT RU https://pubmed.ncbi.nlm.nih.gov/20558073 DM08V9W DI DM08V9W DM08V9W DN 3-Nitro-9H-beta-carboline DM08V9W MI TT1MPAY DM08V9W MN GABA(A) receptor alpha-1 (GABRA1) DM08V9W MT DTT DM08V9W MA Inhibitor DM08V9W RN Synthesis of novel 3-substituted beta-carbolines as benzodiazepine receptor ligands: probing the benzodiazepine receptor pharmacophore. J Med Chem. 1988 Sep;31(9):1854-61. DM08V9W RU https://pubmed.ncbi.nlm.nih.gov/2842507 DM08V9W DI DM08V9W DM08V9W DN 3-Nitro-9H-beta-carboline DM08V9W MI TTNJYV2 DM08V9W MN Gamma-aminobutyric acid receptor (GAR) DM08V9W MT DTT DM08V9W MA Inhibitor DM08V9W RN Synthesis of novel 3-substituted beta-carbolines as benzodiazepine receptor ligands: probing the benzodiazepine receptor pharmacophore. J Med Chem. 1988 Sep;31(9):1854-61. DM08V9W RU https://pubmed.ncbi.nlm.nih.gov/2842507 DMAY4OZ DI DMAY4OZ DMAY4OZ DN 3-Nitro-benzenesulfonamide DMAY4OZ MI TTUNARX DMAY4OZ MN Carbonic anhydrase (CA) DMAY4OZ MT DTT DMAY4OZ MA Inhibitor DMAY4OZ RN Carbonic anhydrase inhibitors: inhibition of human cytosolic isozyme II and mitochondrial isozyme V with a series of benzene sulfonamide derivatives. Bioorg Med Chem Lett. 2004 Nov 15;14(22):5703-7. DMAY4OZ RU https://pubmed.ncbi.nlm.nih.gov/15482952 DMAY4OZ DI DMAY4OZ DMAY4OZ DN 3-Nitro-benzenesulfonamide DMAY4OZ MI TTANPDJ DMAY4OZ MN Carbonic anhydrase II (CA-II) DMAY4OZ MT DTT DMAY4OZ MA Inhibitor DMAY4OZ RN Carbonic anhydrase inhibitors: inhibition of human cytosolic isozyme II and mitochondrial isozyme V with a series of benzene sulfonamide derivatives. Bioorg Med Chem Lett. 2004 Nov 15;14(22):5703-7. DMAY4OZ RU https://pubmed.ncbi.nlm.nih.gov/15482952 DMIZJ9G DI DMIZJ9G DMIZJ9G DN 3-nitro-N-(1,3-diphenyl-1H-pyrazol-5-yl)benzamide DMIZJ9G MI TTHS256 DMIZJ9G MN Metabotropic glutamate receptor 5 (mGluR5) DMIZJ9G MT DTT DMIZJ9G MA Inhibitor DMIZJ9G RN Substituent effects of N-(1,3-diphenyl-1H-pyrazol-5-yl)benzamides on positive allosteric modulation of the metabotropic glutamate-5 receptor in rat... J Med Chem. 2006 Jun 1;49(11):3332-44. DMIZJ9G RU https://pubmed.ncbi.nlm.nih.gov/16722652 DMPMX8R DI DMPMX8R DMPMX8R DN 3-Nitrophenylboronic Acid DMPMX8R MI TTHI19T DMPMX8R MN Staphylococcus Beta-lactamase (Stap-coc blaZ) DMPMX8R MT DTT DMPMX8R MA Inhibitor DMPMX8R RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMPMX8R RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMH798G DI DMH798G DMH798G DN 3-nitropropionate DMH798G MI TT58ZYW DMH798G MN Mycobacterium Isocitrate lyase (MycB icl) DMH798G MT DTT DMH798G MA Inhibitor DMH798G RN Structure of isocitrate lyase, a persistence factor of Mycobacterium tuberculosis. Nat Struct Biol. 2000 Aug;7(8):663-8. DMH798G RU https://pubmed.ncbi.nlm.nih.gov/10932251 DMFHYAE DI DMFHYAE DMFHYAE DN 3-noradamantyl-1,3-dipropylxanthine DMFHYAE MI TTK25J1 DMFHYAE MN Adenosine A1 receptor (ADORA1) DMFHYAE MT DTT DMFHYAE MA Inhibitor DMFHYAE RN Potent and orally bioavailable 8-bicyclo[2.2.2]octylxanthines as adenosine A1 receptor antagonists. J Med Chem. 2006 Nov 30;49(24):7119-31. DMFHYAE RU https://pubmed.ncbi.nlm.nih.gov/17125264 DMFHYAE DI DMFHYAE DMFHYAE DN 3-noradamantyl-1,3-dipropylxanthine DMFHYAE MI TTM2AOE DMFHYAE MN Adenosine A2a receptor (ADORA2A) DMFHYAE MT DTT DMFHYAE MA Inhibitor DMFHYAE RN Potent and orally bioavailable 8-bicyclo[2.2.2]octylxanthines as adenosine A1 receptor antagonists. J Med Chem. 2006 Nov 30;49(24):7119-31. DMFHYAE RU https://pubmed.ncbi.nlm.nih.gov/17125264 DMFHYAE DI DMFHYAE DMFHYAE DN 3-noradamantyl-1,3-dipropylxanthine DMFHYAE MI TTNE7KG DMFHYAE MN Adenosine A2b receptor (ADORA2B) DMFHYAE MT DTT DMFHYAE MA Inhibitor DMFHYAE RN Potent and orally bioavailable 8-bicyclo[2.2.2]octylxanthines as adenosine A1 receptor antagonists. J Med Chem. 2006 Nov 30;49(24):7119-31. DMFHYAE RU https://pubmed.ncbi.nlm.nih.gov/17125264 DMFHYAE DI DMFHYAE DMFHYAE DN 3-noradamantyl-1,3-dipropylxanthine DMFHYAE MI TTJFY5U DMFHYAE MN Adenosine A3 receptor (ADORA3) DMFHYAE MT DTT DMFHYAE MA Inhibitor DMFHYAE RN Potent and orally bioavailable 8-bicyclo[2.2.2]octylxanthines as adenosine A1 receptor antagonists. J Med Chem. 2006 Nov 30;49(24):7119-31. DMFHYAE RU https://pubmed.ncbi.nlm.nih.gov/17125264 DMVIZ1S DI DMVIZ1S DMVIZ1S DN 3-O-METHYLQUERCETIN DMVIZ1S MI TT7RJY8 DMVIZ1S MN Xanthine dehydrogenase/oxidase (XDH) DMVIZ1S MT DTT DMVIZ1S MA Inhibitor DMVIZ1S RN Inhibition of cow's milk xanthine oxidase by flavonoids. J Nat Prod. 1988 Mar-Apr;51(2):345-8. DMVIZ1S RU https://pubmed.ncbi.nlm.nih.gov/3379415 DMVIRLX DI DMVIRLX DMVIRLX DN 3-Oximo-olean-12-en-29-oic acid DMVIRLX MI TTIU7X1 DMVIRLX MN Herpes simplex virus DNA polymerase UL30 (HSV UL30) DMVIRLX MT DTT DMVIRLX MA Inhibitor DMVIRLX RN DNA polymerase beta inhibitors from Sandoricum koetjape. J Nat Prod. 1999 Aug;62(8):1110-3. DMVIRLX RU https://pubmed.ncbi.nlm.nih.gov/10479314 DM47ZWK DI DM47ZWK DM47ZWK DN 3'-Oxo-Adenosine DM47ZWK MI TTE2KUJ DM47ZWK MN Adenosylhomocysteinase (AHCY) DM47ZWK MT DTT DM47ZWK MA Inhibitor DM47ZWK RN DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Nucleic Acids Res. 2011 Jan;39(Database issue):D1035-41. DM47ZWK RU https://pubmed.ncbi.nlm.nih.gov/21059682 DM6JYWQ DI DM6JYWQ DM6JYWQ DN 3-oxoolean-12-en-27-oic acid DM6JYWQ MI TTELIN2 DM6JYWQ MN PTPN1 messenger RNA (PTPN1 mRNA) DM6JYWQ MT DTT DM6JYWQ MA Inhibitor DM6JYWQ RN Protein tyrosine phosphatase 1B inhibitory activity of triterpenes isolated from Astilbe koreana. Bioorg Med Chem Lett. 2006 Jun 15;16(12):3273-6. DM6JYWQ RU https://pubmed.ncbi.nlm.nih.gov/16580200 DMOLZ65 DI DMOLZ65 DMOLZ65 DN 3-phenacyl-UDP DMOLZ65 MI TTNVSKA DMOLZ65 MN P2Y purinoceptor 6 (P2RY6) DMOLZ65 MT DTT DMOLZ65 MA Agonist DMOLZ65 RN Synthesis and structure-activity relationships of uracil nucleotide derivatives and analogues as agonists at human P2Y2, P2Y4, and P2Y6 receptors. J Med Chem. 2006 Nov 30;49(24):7076-87. DMOLZ65 RU https://pubmed.ncbi.nlm.nih.gov/17125260 DM7RWQT DI DM7RWQT DM7RWQT DN 3-Phenanthren-9-yl-pyridine DM7RWQT MI TTIQUX7 DM7RWQT MN Steroid 11-beta-hydroxylase (CYP11B1) DM7RWQT MT DTT DM7RWQT MA Inhibitor DM7RWQT RN Heteroaryl-substituted naphthalenes and structurally modified derivatives: selective inhibitors of CYP11B2 for the treatment of congestive heart fa... J Med Chem. 2005 Oct 20;48(21):6632-42. DM7RWQT RU https://pubmed.ncbi.nlm.nih.gov/16220979 DMVSQFI DI DMVSQFI DMVSQFI DN 3-Phenethyl-2-phenyl-3H-quinazolin-4-one DMVSQFI MI TTBUYHA DMVSQFI MN Extracellular calcium-sensing receptor (CASR) DMVSQFI MT DTT DMVSQFI MA Inhibitor DMVSQFI RN 3H-Quinazolin-4-ones as a new calcilytic template for the potential treatment of osteoporosis. Bioorg Med Chem Lett. 2005 Mar 15;15(6):1557-60. DMVSQFI RU https://pubmed.ncbi.nlm.nih.gov/15745796 DMGPOZE DI DMGPOZE DMGPOZE DN 3-Phenyl-1-(2-methylthiazol-4-ylethynyl)benzene DMGPOZE MI TTHS256 DMGPOZE MN Metabotropic glutamate receptor 5 (mGluR5) DMGPOZE MT DTT DMGPOZE MA Inhibitor DMGPOZE RN Structure-activity relationships comparing N-(6-methylpyridin-yl)-substituted aryl amides to 2-methyl-6-(substituted-arylethynyl)pyridines or 2-met... J Med Chem. 2009 Jun 11;52(11):3563-75. DMGPOZE RU https://pubmed.ncbi.nlm.nih.gov/19445453 DMU9WGT DI DMU9WGT DMU9WGT DN 3-Phenyl-1,2-Propandiol DMU9WGT MI TTB2MXP DMU9WGT MN Angiotensinogenase renin (REN) DMU9WGT MT DTT DMU9WGT MA Inhibitor DMU9WGT RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMU9WGT RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMD0OZ8 DI DMD0OZ8 DMD0OZ8 DN 3-phenyl-1,4-dihydroindeno[1,2-c]pyrazole DMD0OZ8 MI TTUTJGQ DMD0OZ8 MN Vascular endothelial growth factor receptor 2 (KDR) DMD0OZ8 MT DTT DMD0OZ8 MA Inhibitor DMD0OZ8 RN Hit-to-lead optimization of 1,4-dihydroindeno[1,2-c]pyrazoles as a novel class of KDR kinase inhibitors. Bioorg Med Chem Lett. 2006 Aug 15;16(16):4371-5. DMD0OZ8 RU https://pubmed.ncbi.nlm.nih.gov/16750628 DM568CK DI DM568CK DM568CK DN 3-Phenyl-1-propyl-piperidine hydrochloride DM568CK MI TTEX248 DM568CK MN Dopamine D2 receptor (D2R) DM568CK MT DTT DM568CK MA Inhibitor DM568CK RN New N-n-propyl-substituted 3-aryl- and 3-cyclohexylpiperidines as partial agonists at the D4 dopamine receptor. J Med Chem. 2003 Jan 2;46(1):161-8. DM568CK RU https://pubmed.ncbi.nlm.nih.gov/12502370 DMJ0SVB DI DMJ0SVB DMJ0SVB DN 3-Phenyl-1-propyl-pyrrolidine DMJ0SVB MI TTSQIFT DMJ0SVB MN 5-HT 1A receptor (HTR1A) DMJ0SVB MT DTT DMJ0SVB MA Inhibitor DMJ0SVB RN Regioselective synthesis of 3-aryl substituted pyrrolidines via palladium catalyzed arylation: pharmacological evaluation for central dopaminergic and serotonergic activity, Bioorg. Med. Chem. Lett. 7(3):241-246 (1997). DMJ0SVB RU http://www.sciencedirect.com/science/article/pii/S0960894X9600618X DMJ0SVB DI DMJ0SVB DMJ0SVB DN 3-Phenyl-1-propyl-pyrrolidine DMJ0SVB MI TTEX248 DMJ0SVB MN Dopamine D2 receptor (D2R) DMJ0SVB MT DTT DMJ0SVB MA Inhibitor DMJ0SVB RN Regioselective synthesis of 3-aryl substituted pyrrolidines via palladium catalyzed arylation: pharmacological evaluation for central dopaminergic and serotonergic activity, Bioorg. Med. Chem. Lett. 7(3):241-246 (1997). DMJ0SVB RU http://www.sciencedirect.com/science/article/pii/S0960894X9600618X DMEG3YX DI DMEG3YX DMEG3YX DN 3-Phenyl-1-propylquinazoline-2,4(1H,3H)-dione DMEG3YX MI TTUV8G9 DMEG3YX MN Progesterone receptor (PGR) DMEG3YX MT DTT DMEG3YX MA Inhibitor DMEG3YX RN Progesterone receptor antagonists with a 3-phenylquinazoline-2,4-dione/2-phenylisoquinoline-1,3-dione skeleton. Bioorg Med Chem. 2008 Jul 15;16(14):7046-54. DMEG3YX RU https://pubmed.ncbi.nlm.nih.gov/18586498 DMAJMU6 DI DMAJMU6 DMAJMU6 DN 3-Phenyl-2-nortropene DMAJMU6 MI TTVBI8W DMAJMU6 MN Dopamine transporter (DAT) DMAJMU6 MT DTT DMAJMU6 MA Inhibitor DMAJMU6 RN Synthesis and monoamine transporter affinity of 3alpha-arylmethoxy-3beta-arylnortropanes. Bioorg Med Chem Lett. 2009 Dec 15;19(24):6865-8. DMAJMU6 RU https://pubmed.ncbi.nlm.nih.gov/19896846 DMAJMU6 DI DMAJMU6 DMAJMU6 DN 3-Phenyl-2-nortropene DMAJMU6 MI TT3ROYC DMAJMU6 MN Serotonin transporter (SERT) DMAJMU6 MT DTT DMAJMU6 MA Inhibitor DMAJMU6 RN Synthesis and monoamine transporter affinity of 3alpha-arylmethoxy-3beta-arylnortropanes. Bioorg Med Chem Lett. 2009 Dec 15;19(24):6865-8. DMAJMU6 RU https://pubmed.ncbi.nlm.nih.gov/19896846 DM6T5K4 DI DM6T5K4 DM6T5K4 DN 3-phenyl-4-(phenylamino)-1H-pyrrole-2,5-dione DM6T5K4 MI TTRSMW9 DM6T5K4 MN Glycogen synthase kinase-3 beta (GSK-3B) DM6T5K4 MT DTT DM6T5K4 MA Inhibitor DM6T5K4 RN Novel GSK-3beta inhibitors from sequential virtual screening. Bioorg Med Chem. 2008 Jan 15;16(2):636-43. DM6T5K4 RU https://pubmed.ncbi.nlm.nih.gov/18006321 DM2C9X8 DI DM2C9X8 DM2C9X8 DN 3-phenyl-4-hydroxyquinolin-2(1H)-one DM2C9X8 MI TTLD29N DM2C9X8 MN Glutamate receptor ionotropic NMDA 1 (NMDAR1) DM2C9X8 MT DTT DM2C9X8 MA Inhibitor DM2C9X8 RN Synthesis of thieno[2,3-b]pyridinones acting as cytoprotectants and as inhibitors of [3H]glycine binding to the N-methyl-D-aspartate (NMDA) receptor. J Med Chem. 2006 Feb 9;49(3):864-71. DM2C9X8 RU https://pubmed.ncbi.nlm.nih.gov/16451052 DM2C9X8 DI DM2C9X8 DM2C9X8 DN 3-phenyl-4-hydroxyquinolin-2(1H)-one DM2C9X8 MI TTKJEMQ DM2C9X8 MN Glutamate receptor ionotropic NMDA 2A (NMDAR2A) DM2C9X8 MT DTT DM2C9X8 MA Inhibitor DM2C9X8 RN Synthesis of thieno[2,3-b]pyridinones acting as cytoprotectants and as inhibitors of [3H]glycine binding to the N-methyl-D-aspartate (NMDA) receptor. J Med Chem. 2006 Feb 9;49(3):864-71. DM2C9X8 RU https://pubmed.ncbi.nlm.nih.gov/16451052 DM2C9X8 DI DM2C9X8 DM2C9X8 DN 3-phenyl-4-hydroxyquinolin-2(1H)-one DM2C9X8 MI TTN9D8E DM2C9X8 MN Glutamate receptor ionotropic NMDA 2B (NMDAR2B) DM2C9X8 MT DTT DM2C9X8 MA Inhibitor DM2C9X8 RN Synthesis of thieno[2,3-b]pyridinones acting as cytoprotectants and as inhibitors of [3H]glycine binding to the N-methyl-D-aspartate (NMDA) receptor. J Med Chem. 2006 Feb 9;49(3):864-71. DM2C9X8 RU https://pubmed.ncbi.nlm.nih.gov/16451052 DM43CIK DI DM43CIK DM43CIK DN 3-phenyl-5-sulfamoyl-1H-indole-2-carboxamide DM43CIK MI TTHQPL7 DM43CIK MN Carbonic anhydrase I (CA-I) DM43CIK MT DTT DM43CIK MA Inhibitor DM43CIK RN Discovery of low nanomolar and subnanomolar inhibitors of the mycobacterial beta-carbonic anhydrases Rv1284 and Rv3273. J Med Chem. 2009 Jul 9;52(13):4063-7. DM43CIK RU https://pubmed.ncbi.nlm.nih.gov/19438226 DM43CIK DI DM43CIK DM43CIK DN 3-phenyl-5-sulfamoyl-1H-indole-2-carboxamide DM43CIK MI TTANPDJ DM43CIK MN Carbonic anhydrase II (CA-II) DM43CIK MT DTT DM43CIK MA Inhibitor DM43CIK RN Discovery of low nanomolar and subnanomolar inhibitors of the mycobacterial beta-carbonic anhydrases Rv1284 and Rv3273. J Med Chem. 2009 Jul 9;52(13):4063-7. DM43CIK RU https://pubmed.ncbi.nlm.nih.gov/19438226 DM830FW DI DM830FW DM830FW DN 3-phenyl-9H-indeno[1,2-e][1,2,4]triazin-9-one DM830FW MI TTGP7BY DM830FW MN Monoamine oxidase type B (MAO-B) DM830FW MT DTT DM830FW MA Inhibitor DM830FW RN Synthesis and monoamine oxidase inhibitory activity of new pyridazine-, pyrimidine- and 1,2,4-triazine-containing tricyclic derivatives. J Med Chem. 2007 Nov 1;50(22):5364-71. DM830FW RU https://pubmed.ncbi.nlm.nih.gov/17910428 DMQZJYS DI DMQZJYS DMQZJYS DN 3-phenyl-CPP DMQZJYS MI TT823N1 DMQZJYS MN Chloride channel protein ClC-Ka (ClC-K1) DMQZJYS MT DTT DMQZJYS MA Blocker (channel blocker) DMQZJYS RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 700). DMQZJYS RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=700 DMQZJYS DI DMQZJYS DMQZJYS DN 3-phenyl-CPP DMQZJYS MI TTR68GQ DMQZJYS MN Chloride channel protein ClC-Kb (ClC-K2) DMQZJYS MT DTT DMQZJYS MA Blocker (channel blocker) DMQZJYS RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 701). DMQZJYS RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=701 DMJOD1T DI DMJOD1T DMJOD1T DN 3-Phenylcyclopentanecarboxylic acid DMJOD1T MI TT5ZWB6 DMJOD1T MN Dihydrodiol dehydrogenase type I (AKR1C3) DMJOD1T MT DTT DMJOD1T MA Inhibitor DMJOD1T RN New cyclopentane derivatives as inhibitors of steroid metabolizing enzymes AKR1C1 and AKR1C3. Eur J Med Chem. 2009 Jun;44(6):2563-71. DMJOD1T RU https://pubmed.ncbi.nlm.nih.gov/19237229 DM3LM6B DI DM3LM6B DM3LM6B DN 3-phenyl-cyclosal-d4TMP DM3LM6B MI TTEB0GD DM3LM6B MN Cholinesterase (BCHE) DM3LM6B MT DTT DM3LM6B MA Inhibitor DM3LM6B RN Bis-cycloSal-d4T-monophosphates: drugs that deliver two molecules of bioactive nucleotides. J Med Chem. 2007 Mar 22;50(6):1335-46. DM3LM6B RU https://pubmed.ncbi.nlm.nih.gov/17328534 DMIJN9E DI DMIJN9E DMIJN9E DN 3-phenylprop-1-enylboronic acid DMIJN9E MI TTHQPL7 DMIJN9E MN Carbonic anhydrase I (CA-I) DMIJN9E MT DTT DMIJN9E MA Inhibitor DMIJN9E RN Carbonic anhydrase inhibitors. Inhibition of the fungal beta-carbonic anhydrases from Candida albicans and Cryptococcus neoformans with boronic acids. Bioorg Med Chem Lett. 2009 May 15;19(10):2642-5. DMIJN9E RU https://pubmed.ncbi.nlm.nih.gov/19375309 DMIJN9E DI DMIJN9E DMIJN9E DN 3-phenylprop-1-enylboronic acid DMIJN9E MI TTANPDJ DMIJN9E MN Carbonic anhydrase II (CA-II) DMIJN9E MT DTT DMIJN9E MA Inhibitor DMIJN9E RN Carbonic anhydrase inhibitors. Inhibition of the fungal beta-carbonic anhydrases from Candida albicans and Cryptococcus neoformans with boronic acids. Bioorg Med Chem Lett. 2009 May 15;19(10):2642-5. DMIJN9E RU https://pubmed.ncbi.nlm.nih.gov/19375309 DMBTDZL DI DMBTDZL DMBTDZL DN 3-Phenyl-pyrrolidine DMBTDZL MI TTEX248 DMBTDZL MN Dopamine D2 receptor (D2R) DMBTDZL MT DTT DMBTDZL MA Inhibitor DMBTDZL RN Regioselective synthesis of 3-aryl substituted pyrrolidines via palladium catalyzed arylation: pharmacological evaluation for central dopaminergic and serotonergic activity, Bioorg. Med. Chem. Lett. 7(3):241-246 (1997). DMBTDZL RU http://www.sciencedirect.com/science/article/pii/S0960894X9600618X DM12SKU DI DM12SKU DM12SKU DN 3-Phenylquinoline-8-carboxamide DM12SKU MI TTVDSZ0 DM12SKU MN Poly [ADP-ribose] polymerase 1 (PARP1) DM12SKU MT DTT DM12SKU MA Inhibitor DM12SKU RN Design, synthesis, and evaluation in vitro of quinoline-8-carboxamides, a new class of poly(adenosine-diphosphate-ribose)polymerase-1 (PARP-1) inhi... J Med Chem. 2009 Feb 12;52(3):868-77. DM12SKU RU https://pubmed.ncbi.nlm.nih.gov/19117416 DMRNHXE DI DMRNHXE DMRNHXE DN 3-Phenylsulfanylmethyl-quinoxaline-5,7-diamine DMRNHXE MI TT9SL3Q DMRNHXE MN Polypeptide deformylase (PDF) DMRNHXE MT DTT DMRNHXE MA Inhibitor DMRNHXE RN New drug developments for opportunistic infections in immunosuppressed patients: Pneumocystis carinii. J Med Chem. 1995 Nov 24;38(24):4739-59. DMRNHXE RU https://pubmed.ncbi.nlm.nih.gov/7490723 DMIK9VO DI DMIK9VO DMIK9VO DN 3-Phosphoglyceric Acid DMIK9VO MI TTNS6X4 DMIK9VO MN Bacterial Triosephosphate isomerase (Bact TPI) DMIK9VO MT DTT DMIK9VO MA Inhibitor DMIK9VO RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMIK9VO RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMIK9VO DI DMIK9VO DMIK9VO DN 3-Phosphoglyceric Acid DMIK9VO MI TTHJWVK DMIK9VO MN Mycobacterium Bisphosphoglycerate phosphoglycerate mutase (MycB gpmI) DMIK9VO MT DTT DMIK9VO MA Inhibitor DMIK9VO RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMIK9VO RU https://pubmed.ncbi.nlm.nih.gov/17139284 DM9BDV2 DI DM9BDV2 DM9BDV2 DN 3-Phosphoglycerol DM9BDV2 MI TTHB48R DM9BDV2 MN Bacterial Pyridoxal phosphate biosynthetic pdxJ (Bact pdxJ) DM9BDV2 MT DTT DM9BDV2 MA Inhibitor DM9BDV2 RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DM9BDV2 RU https://pubmed.ncbi.nlm.nih.gov/17139284 DM9BDV2 DI DM9BDV2 DM9BDV2 DN 3-Phosphoglycerol DM9BDV2 MI TTNS6X4 DM9BDV2 MN Bacterial Triosephosphate isomerase (Bact TPI) DM9BDV2 MT DTT DM9BDV2 MA Inhibitor DM9BDV2 RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DM9BDV2 RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMPF5OX DI DMPF5OX DMPF5OX DN 3PO DMPF5OX MI TTTHMQJ DMPF5OX MN Renal carcinoma antigen NY-REN-56 (PFKFB3) DMPF5OX MT DTT DMPF5OX MA Antagonist DMPF5OX RN CPEB4 Increases Expression of PFKFB3 to Induce Glycolysis and Activate Mouse and Human Hepatic Stellate Cells, Promoting Liver Fibrosis. Gastroenterology. 2020 Jul;159(1):273-288. DMPF5OX RU https://pubmed.ncbi.nlm.nih.gov/32169429 DM23I8E DI DM23I8E DM23I8E DN 3-Prop-1-ynylquinoline-8-carboxamide DM23I8E MI TTVDSZ0 DM23I8E MN Poly [ADP-ribose] polymerase 1 (PARP1) DM23I8E MT DTT DM23I8E MA Inhibitor DM23I8E RN Design, synthesis, and evaluation in vitro of quinoline-8-carboxamides, a new class of poly(adenosine-diphosphate-ribose)polymerase-1 (PARP-1) inhi... J Med Chem. 2009 Feb 12;52(3):868-77. DM23I8E RU https://pubmed.ncbi.nlm.nih.gov/19117416 DMDEV64 DI DMDEV64 DMDEV64 DN 3-Propoxy-9H-beta-carboline DMDEV64 MI TT1MPAY DMDEV64 MN GABA(A) receptor alpha-1 (GABRA1) DMDEV64 MT DTT DMDEV64 MA Inhibitor DMDEV64 RN Synthesis of novel 3-substituted beta-carbolines as benzodiazepine receptor ligands: probing the benzodiazepine receptor pharmacophore. J Med Chem. 1988 Sep;31(9):1854-61. DMDEV64 RU https://pubmed.ncbi.nlm.nih.gov/2842507 DMDEV64 DI DMDEV64 DMDEV64 DN 3-Propoxy-9H-beta-carboline DMDEV64 MI TTBMV1G DMDEV64 MN GABA(A) receptor alpha-2 (GABRA2) DMDEV64 MT DTT DMDEV64 MA Inhibitor DMDEV64 RN Design, synthesis, and subtype selectivity of 3,6-disubstituted -carbolines at Bz/GABA(A)ergic receptors. SAR and studies directed toward agents f... Bioorg Med Chem. 2010 Nov 1;18(21):7548-64. DMDEV64 RU https://pubmed.ncbi.nlm.nih.gov/20888240 DMDEV64 DI DMDEV64 DMDEV64 DN 3-Propoxy-9H-beta-carboline DMDEV64 MI TT37EDJ DMDEV64 MN GABA(A) receptor alpha-3 (GABRA3) DMDEV64 MT DTT DMDEV64 MA Inhibitor DMDEV64 RN Design, synthesis, and subtype selectivity of 3,6-disubstituted -carbolines at Bz/GABA(A)ergic receptors. SAR and studies directed toward agents f... Bioorg Med Chem. 2010 Nov 1;18(21):7548-64. DMDEV64 RU https://pubmed.ncbi.nlm.nih.gov/20888240 DMDEV64 DI DMDEV64 DMDEV64 DN 3-Propoxy-9H-beta-carboline DMDEV64 MI TTNZPQ1 DMDEV64 MN GABA(A) receptor alpha-5 (GABRA5) DMDEV64 MT DTT DMDEV64 MA Inhibitor DMDEV64 RN Design, synthesis, and subtype selectivity of 3,6-disubstituted -carbolines at Bz/GABA(A)ergic receptors. SAR and studies directed toward agents f... Bioorg Med Chem. 2010 Nov 1;18(21):7548-64. DMDEV64 RU https://pubmed.ncbi.nlm.nih.gov/20888240 DMDEV64 DI DMDEV64 DMDEV64 DN 3-Propoxy-9H-beta-carboline DMDEV64 MI TT06RH5 DMDEV64 MN GABA(A) receptor gamma-2 (GABRG2) DMDEV64 MT DTT DMDEV64 MA Inhibitor DMDEV64 RN Design, synthesis, and subtype selectivity of 3,6-disubstituted -carbolines at Bz/GABA(A)ergic receptors. SAR and studies directed toward agents f... Bioorg Med Chem. 2010 Nov 1;18(21):7548-64. DMDEV64 RU https://pubmed.ncbi.nlm.nih.gov/20888240 DMDEV64 DI DMDEV64 DMDEV64 DN 3-Propoxy-9H-beta-carboline DMDEV64 MI TTNJYV2 DMDEV64 MN Gamma-aminobutyric acid receptor (GAR) DMDEV64 MT DTT DMDEV64 MA Inhibitor DMDEV64 RN Synthesis of novel 3-substituted beta-carbolines as benzodiazepine receptor ligands: probing the benzodiazepine receptor pharmacophore. J Med Chem. 1988 Sep;31(9):1854-61. DMDEV64 RU https://pubmed.ncbi.nlm.nih.gov/2842507 DMYACO7 DI DMYACO7 DMYACO7 DN 3-Propyl-[1,4]thiazepan-(5E)-ylideneamine DMYACO7 MI TTZUFI5 DMYACO7 MN Nitric-oxide synthase brain (NOS1) DMYACO7 MT DTT DMYACO7 MA Inhibitor DMYACO7 RN Synthesis of analogs of (1,4)-3- and 5-imino oxazepane, thiazepane, and diazepane as inhibitors of nitric oxide synthases. Bioorg Med Chem Lett. 2004 Dec 6;14(23):5907-11. DMYACO7 RU https://pubmed.ncbi.nlm.nih.gov/15501067 DMYACO7 DI DMYACO7 DMYACO7 DN 3-Propyl-[1,4]thiazepan-(5E)-ylideneamine DMYACO7 MI TTF10I9 DMYACO7 MN Nitric-oxide synthase inducible (NOS2) DMYACO7 MT DTT DMYACO7 MA Inhibitor DMYACO7 RN Synthesis of analogs of (1,4)-3- and 5-imino oxazepane, thiazepane, and diazepane as inhibitors of nitric oxide synthases. Bioorg Med Chem Lett. 2004 Dec 6;14(23):5907-11. DMYACO7 RU https://pubmed.ncbi.nlm.nih.gov/15501067 DM0872E DI DM0872E DM0872E DN 3-p-Tolyl-8-aza-bicyclo[3.2.1]octane DM0872E MI TTVBI8W DM0872E MN Dopamine transporter (DAT) DM0872E MT DTT DM0872E MA Inhibitor DM0872E RN 3alpha-(4-Substituted phenyl)nortropane-2beta-carboxylic acid methyl esters show selective binding at the norepinephrine transporter. Bioorg Med Chem Lett. 2000 Nov 6;10(21):2445-7. DM0872E RU https://pubmed.ncbi.nlm.nih.gov/11078197 DM0872E DI DM0872E DM0872E DN 3-p-Tolyl-8-aza-bicyclo[3.2.1]octane DM0872E MI TTAWNKZ DM0872E MN Norepinephrine transporter (NET) DM0872E MT DTT DM0872E MA Inhibitor DM0872E RN 3alpha-(4-Substituted phenyl)nortropane-2beta-carboxylic acid methyl esters show selective binding at the norepinephrine transporter. Bioorg Med Chem Lett. 2000 Nov 6;10(21):2445-7. DM0872E RU https://pubmed.ncbi.nlm.nih.gov/11078197 DM0872E DI DM0872E DM0872E DN 3-p-Tolyl-8-aza-bicyclo[3.2.1]octane DM0872E MI TT3ROYC DM0872E MN Serotonin transporter (SERT) DM0872E MT DTT DM0872E MA Inhibitor DM0872E RN 3alpha-(4-Substituted phenyl)nortropane-2beta-carboxylic acid methyl esters show selective binding at the norepinephrine transporter. Bioorg Med Chem Lett. 2000 Nov 6;10(21):2445-7. DM0872E RU https://pubmed.ncbi.nlm.nih.gov/11078197 DM60Q1B DI DM60Q1B DM60Q1B DN 3-Pyridin-3-yl-quinoline-6,7-diol DM60Q1B MI TT8FYO9 DM60Q1B MN Platelet-derived growth factor receptor alpha (PDGFRA) DM60Q1B MT DTT DM60Q1B MA Inhibitor DM60Q1B RN A new series of PDGF receptor tyrosine kinase inhibitors: 3-substituted quinoline derivatives. J Med Chem. 1994 Jul 8;37(14):2129-37. DM60Q1B RU https://pubmed.ncbi.nlm.nih.gov/8035419 DM60Q1B DI DM60Q1B DM60Q1B DN 3-Pyridin-3-yl-quinoline-6,7-diol DM60Q1B MI TTI7421 DM60Q1B MN Platelet-derived growth factor receptor beta (PDGFRB) DM60Q1B MT DTT DM60Q1B MA Inhibitor DM60Q1B RN A new series of PDGF receptor tyrosine kinase inhibitors: 3-substituted quinoline derivatives. J Med Chem. 1994 Jul 8;37(14):2129-37. DM60Q1B RU https://pubmed.ncbi.nlm.nih.gov/8035419 DM0SEL5 DI DM0SEL5 DM0SEL5 DN 3-Pyridin-4-yl-quinolin-7-ol DM0SEL5 MI TT8FYO9 DM0SEL5 MN Platelet-derived growth factor receptor alpha (PDGFRA) DM0SEL5 MT DTT DM0SEL5 MA Inhibitor DM0SEL5 RN 5,7-Dimethoxy-3-(4-pyridinyl)quinoline is a potent and selective inhibitor of human vascular beta-type platelet-derived growth factor receptor tyro... J Med Chem. 1994 Aug 19;37(17):2627-9. DM0SEL5 RU https://pubmed.ncbi.nlm.nih.gov/8064792 DM0SEL5 DI DM0SEL5 DM0SEL5 DN 3-Pyridin-4-yl-quinolin-7-ol DM0SEL5 MI TTI7421 DM0SEL5 MN Platelet-derived growth factor receptor beta (PDGFRB) DM0SEL5 MT DTT DM0SEL5 MA Inhibitor DM0SEL5 RN 5,7-Dimethoxy-3-(4-pyridinyl)quinoline is a potent and selective inhibitor of human vascular beta-type platelet-derived growth factor receptor tyro... J Med Chem. 1994 Aug 19;37(17):2627-9. DM0SEL5 RU https://pubmed.ncbi.nlm.nih.gov/8064792 DM6U074 DI DM6U074 DM6U074 DN 3-Pyridin-4-yl-quinoline DM6U074 MI TT8FYO9 DM6U074 MN Platelet-derived growth factor receptor alpha (PDGFRA) DM6U074 MT DTT DM6U074 MA Inhibitor DM6U074 RN 5,7-Dimethoxy-3-(4-pyridinyl)quinoline is a potent and selective inhibitor of human vascular beta-type platelet-derived growth factor receptor tyro... J Med Chem. 1994 Aug 19;37(17):2627-9. DM6U074 RU https://pubmed.ncbi.nlm.nih.gov/8064792 DM6U074 DI DM6U074 DM6U074 DN 3-Pyridin-4-yl-quinoline DM6U074 MI TTI7421 DM6U074 MN Platelet-derived growth factor receptor beta (PDGFRB) DM6U074 MT DTT DM6U074 MA Inhibitor DM6U074 RN 5,7-Dimethoxy-3-(4-pyridinyl)quinoline is a potent and selective inhibitor of human vascular beta-type platelet-derived growth factor receptor tyro... J Med Chem. 1994 Aug 19;37(17):2627-9. DM6U074 RU https://pubmed.ncbi.nlm.nih.gov/8064792 DMPCT0A DI DMPCT0A DMPCT0A DN 3-Pyridin-4-yl-quinoline-5,7-diol DMPCT0A MI TT8FYO9 DMPCT0A MN Platelet-derived growth factor receptor alpha (PDGFRA) DMPCT0A MT DTT DMPCT0A MA Inhibitor DMPCT0A RN 5,7-Dimethoxy-3-(4-pyridinyl)quinoline is a potent and selective inhibitor of human vascular beta-type platelet-derived growth factor receptor tyro... J Med Chem. 1994 Aug 19;37(17):2627-9. DMPCT0A RU https://pubmed.ncbi.nlm.nih.gov/8064792 DMPCT0A DI DMPCT0A DMPCT0A DN 3-Pyridin-4-yl-quinoline-5,7-diol DMPCT0A MI TTI7421 DMPCT0A MN Platelet-derived growth factor receptor beta (PDGFRB) DMPCT0A MT DTT DMPCT0A MA Inhibitor DMPCT0A RN 5,7-Dimethoxy-3-(4-pyridinyl)quinoline is a potent and selective inhibitor of human vascular beta-type platelet-derived growth factor receptor tyro... J Med Chem. 1994 Aug 19;37(17):2627-9. DMPCT0A RU https://pubmed.ncbi.nlm.nih.gov/8064792 DME1TUK DI DME1TUK DME1TUK DN 3-Pyridin-4-yl-quinoline-6,7-diol DME1TUK MI TTGKNB4 DME1TUK MN Epidermal growth factor receptor (EGFR) DME1TUK MT DTT DME1TUK MA Inhibitor DME1TUK RN 5,7-Dimethoxy-3-(4-pyridinyl)quinoline is a potent and selective inhibitor of human vascular beta-type platelet-derived growth factor receptor tyro... J Med Chem. 1994 Aug 19;37(17):2627-9. DME1TUK RU https://pubmed.ncbi.nlm.nih.gov/8064792 DMAGXMJ DI DMAGXMJ DMAGXMJ DN 3-pyridine-acetic acid DMAGXMJ MI TTWNV8U DMAGXMJ MN Nicotinic acid receptor (HCAR2) DMAGXMJ MT DTT DMAGXMJ MA Agonist DMAGXMJ RN Molecular identification of high and low affinity receptors for nicotinic acid. J Biol Chem. 2003 Mar 14;278(11):9869-74. DMAGXMJ RU https://pubmed.ncbi.nlm.nih.gov/12522134 DM2KEW6 DI DM2KEW6 DM2KEW6 DN 3R14S-OCHRATOXIN A DM2KEW6 MI DT9NXMV DM2KEW6 MN ATP-binding cassette sub-family A member 8 (ABCA8) DM2KEW6 MT DTP DM2KEW6 MA Substrate DM2KEW6 RN Functional analysis of ABCA8, a new drug transporter. Biochem Biophys Res Commun. 2002 Oct 18;298(1):41-5. DM2KEW6 RU http://www.ncbi.nlm.nih.gov/pubmed/12379217 DM2KEW6 DI DM2KEW6 DM2KEW6 DN 3R14S-OCHRATOXIN A DM2KEW6 MI DTQ23VB DM2KEW6 MN Organic anion transporter 1 (SLC22A6) DM2KEW6 MT DTP DM2KEW6 MA Substrate DM2KEW6 RN Characterization of ochratoxin A transport by human organic anion transporters. Life Sci. 2001 Sep 21;69(18):2123-35. DM2KEW6 RU http://www.ncbi.nlm.nih.gov/pubmed/11669456 DM2KEW6 DI DM2KEW6 DM2KEW6 DN 3R14S-OCHRATOXIN A DM2KEW6 MI DTVP67E DM2KEW6 MN Organic anion transporter 3 (SLC22A8) DM2KEW6 MT DTP DM2KEW6 MA Substrate DM2KEW6 RN Characterization of ochratoxin A transport by human organic anion transporters. Life Sci. 2001 Sep 21;69(18):2123-35. DM2KEW6 RU http://www.ncbi.nlm.nih.gov/pubmed/11669456 DM2KEW6 DI DM2KEW6 DM2KEW6 DN 3R14S-OCHRATOXIN A DM2KEW6 MI DT06JWZ DM2KEW6 MN Organic anion transporter 4 (SLC22A11) DM2KEW6 MT DTP DM2KEW6 MA Substrate DM2KEW6 RN Role of human organic anion transporter 4 in the transport of ochratoxin A. Biochim Biophys Acta. 2002 Jun 12;1590(1-3):64-75. DM2KEW6 RU http://www.ncbi.nlm.nih.gov/pubmed/12063169 DM2KEW6 DI DM2KEW6 DM2KEW6 DN 3R14S-OCHRATOXIN A DM2KEW6 MI TTTQR47 DM2KEW6 MN Solute carrier family 22 member 8 (SLC22A8) DM2KEW6 MT DTT DM2KEW6 MA Inhibitor DM2KEW6 RN Structural variation governs substrate specificity for organic anion transporter (OAT) homologs. Potential remote sensing by OAT family members. J Biol Chem. 2007 Aug 17;282(33):23841-53. DM2KEW6 RU https://pubmed.ncbi.nlm.nih.gov/17553798 DMV1HMX DI DMV1HMX DMV1HMX DN 3r-Hydroxydecanoyl-Coa DMV1HMX MI TTL1WGS DMV1HMX MN Estradiol 17 beta-dehydrogenase 4 (HSD17B4) DMV1HMX MT DTT DMV1HMX MA Inhibitor DMV1HMX RN DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Nucleic Acids Res. 2011 Jan;39(Database issue):D1035-41. DMV1HMX RU https://pubmed.ncbi.nlm.nih.gov/21059682 DMVGDSM DI DMVGDSM DMVGDSM DN 3S,4R-293B DMVGDSM MI TT846HF DMVGDSM MN Voltage-gated potassium channel Kv7.1 (KCNQ1) DMVGDSM MT DTT DMVGDSM MA Blocker (channel blocker) DMVGDSM RN A kinetic study on the stereospecific inhibition of KCNQ1 and I(Ks) by the chromanol 293B. Br J Pharmacol. 2001 Dec;134(8):1647-54. DMVGDSM RU https://pubmed.ncbi.nlm.nih.gov/11739240 DMCD4GR DI DMCD4GR DMCD4GR DN 3-sal-cyclosal-d4TMP DMCD4GR MI TTEB0GD DMCD4GR MN Cholinesterase (BCHE) DMCD4GR MT DTT DMCD4GR MA Inhibitor DMCD4GR RN Bis-cycloSal-d4T-monophosphates: drugs that deliver two molecules of bioactive nucleotides. J Med Chem. 2007 Mar 22;50(6):1335-46. DMCD4GR RU https://pubmed.ncbi.nlm.nih.gov/17328534 DMNP8DQ DI DMNP8DQ DMNP8DQ DN 3-sec-Butoxy-9H-beta-carboline DMNP8DQ MI TT1MPAY DMNP8DQ MN GABA(A) receptor alpha-1 (GABRA1) DMNP8DQ MT DTT DMNP8DQ MA Inhibitor DMNP8DQ RN Predictive binding of beta-carboline inverse agonists and antagonists via the CoMFA/GOLPE approach. J Med Chem. 1992 Oct 30;35(22):4001-10. DMNP8DQ RU https://pubmed.ncbi.nlm.nih.gov/1331452 DMNP8DQ DI DMNP8DQ DMNP8DQ DN 3-sec-Butoxy-9H-beta-carboline DMNP8DQ MI TTNJYV2 DMNP8DQ MN Gamma-aminobutyric acid receptor (GAR) DMNP8DQ MT DTT DMNP8DQ MA Inhibitor DMNP8DQ RN Predictive binding of beta-carboline inverse agonists and antagonists via the CoMFA/GOLPE approach. J Med Chem. 1992 Oct 30;35(22):4001-10. DMNP8DQ RU https://pubmed.ncbi.nlm.nih.gov/1331452 DMILTRN DI DMILTRN DMILTRN DN 3-Sulfinoalanine DMILTRN MI TTEP6RV DMILTRN MN Glutathione reductase (GR) DMILTRN MT DTT DMILTRN MA Inhibitor DMILTRN RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMILTRN RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMILTRN DI DMILTRN DMILTRN DN 3-Sulfinoalanine DMILTRN MI TTS0EZJ DMILTRN MN Hydroxymethylglutaryl-CoA synthase 2 (HMGCS2) DMILTRN MT DTT DMILTRN MA Inhibitor DMILTRN RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMILTRN RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMILTRN DI DMILTRN DMILTRN DN 3-Sulfinoalanine DMILTRN MI TTICO5G DMILTRN MN Staphylococcus Peptide deformylase (Stap-coc def) DMILTRN MT DTT DMILTRN MA Inhibitor DMILTRN RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMILTRN RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMKSUV9 DI DMKSUV9 DMKSUV9 DN 3-tapap DMKSUV9 MI TTPRO7W DMKSUV9 MN Suppressor of tumorigenicity 14 protein (ST14) DMKSUV9 MT DTT DMKSUV9 MA Inhibitor DMKSUV9 RN Secondary amides of sulfonylated 3-amidinophenylalanine. New potent and selective inhibitors of matriptase. J Med Chem. 2006 Jul 13;49(14):4116-26. DMKSUV9 RU https://pubmed.ncbi.nlm.nih.gov/16821772 DMGDT8V DI DMGDT8V DMGDT8V DN 3-tert-Butyl-3-ethyl-dihydro-furan-2-one DMGDT8V MI TT1MPAY DMGDT8V MN GABA(A) receptor alpha-1 (GABRA1) DMGDT8V MT DTT DMGDT8V MA Inhibitor DMGDT8V RN Alpha-spirocyclopentyl- and alpha-spirocyclopropyl-gamma-butyrolactones: conformationally constrained derivatives of anticonvulsant and convulsant ... J Med Chem. 1994 Jan 21;37(2):275-86. DMGDT8V RU https://pubmed.ncbi.nlm.nih.gov/8295215 DMGDT8V DI DMGDT8V DMGDT8V DN 3-tert-Butyl-3-ethyl-dihydro-furan-2-one DMGDT8V MI TTZA1NY DMGDT8V MN GABA(A) receptor beta-2 (GABRB2) DMGDT8V MT DTT DMGDT8V MA Inhibitor DMGDT8V RN Alpha-spirocyclopentyl- and alpha-spirocyclopropyl-gamma-butyrolactones: conformationally constrained derivatives of anticonvulsant and convulsant ... J Med Chem. 1994 Jan 21;37(2):275-86. DMGDT8V RU https://pubmed.ncbi.nlm.nih.gov/8295215 DMGDT8V DI DMGDT8V DMGDT8V DN 3-tert-Butyl-3-ethyl-dihydro-furan-2-one DMGDT8V MI TT06RH5 DMGDT8V MN GABA(A) receptor gamma-2 (GABRG2) DMGDT8V MT DTT DMGDT8V MA Inhibitor DMGDT8V RN Alpha-spirocyclopentyl- and alpha-spirocyclopropyl-gamma-butyrolactones: conformationally constrained derivatives of anticonvulsant and convulsant ... J Med Chem. 1994 Jan 21;37(2):275-86. DMGDT8V RU https://pubmed.ncbi.nlm.nih.gov/8295215 DMGDT8V DI DMGDT8V DMGDT8V DN 3-tert-Butyl-3-ethyl-dihydro-furan-2-one DMGDT8V MI TTNJYV2 DMGDT8V MN Gamma-aminobutyric acid receptor (GAR) DMGDT8V MT DTT DMGDT8V MA Inhibitor DMGDT8V RN Alpha-spirocyclopentyl- and alpha-spirocyclopropyl-gamma-butyrolactones: conformationally constrained derivatives of anticonvulsant and convulsant ... J Med Chem. 1994 Jan 21;37(2):275-86. DMGDT8V RU https://pubmed.ncbi.nlm.nih.gov/8295215 DMY57CV DI DMY57CV DMY57CV DN 3-tert-butyl-9H-carbazole DMY57CV MI TTBGTCW DMY57CV MN Kinesin spindle messenger RNA (KIF11 mRNA) DMY57CV MT DTT DMY57CV MA Inhibitor DMY57CV RN Kinesin spindle protein (KSP) inhibitors with 2,3-fused indole scaffolds. J Med Chem. 2010 Jul 8;53(13):5054-8. DMY57CV RU https://pubmed.ncbi.nlm.nih.gov/20521839 DMIH6JU DI DMIH6JU DMIH6JU DN 3-Tetrazol-2-yl-1-aza-bicyclo[2.2.2]octane DMIH6JU MI TTZ9SOR DMIH6JU MN Muscarinic acetylcholine receptor M1 (CHRM1) DMIH6JU MT DTT DMIH6JU MA Inhibitor DMIH6JU RN Synthesis and muscarinic activities of quinuclidin-3-yltriazole and -tetrazole derivatives. J Med Chem. 1992 Apr 3;35(7):1280-90. DMIH6JU RU https://pubmed.ncbi.nlm.nih.gov/1560440 DMIH6JU DI DMIH6JU DMIH6JU DN 3-Tetrazol-2-yl-1-aza-bicyclo[2.2.2]octane DMIH6JU MI TTYEG6Q DMIH6JU MN Muscarinic acetylcholine receptor M2 (CHRM2) DMIH6JU MT DTT DMIH6JU MA Inhibitor DMIH6JU RN Synthesis and muscarinic activities of quinuclidin-3-yltriazole and -tetrazole derivatives. J Med Chem. 1992 Apr 3;35(7):1280-90. DMIH6JU RU https://pubmed.ncbi.nlm.nih.gov/1560440 DMIH6JU DI DMIH6JU DMIH6JU DN 3-Tetrazol-2-yl-1-aza-bicyclo[2.2.2]octane DMIH6JU MI TTQ13Z5 DMIH6JU MN Muscarinic acetylcholine receptor M3 (CHRM3) DMIH6JU MT DTT DMIH6JU MA Inhibitor DMIH6JU RN Synthesis and muscarinic activities of quinuclidin-3-yltriazole and -tetrazole derivatives. J Med Chem. 1992 Apr 3;35(7):1280-90. DMIH6JU RU https://pubmed.ncbi.nlm.nih.gov/1560440 DMIH6JU DI DMIH6JU DMIH6JU DN 3-Tetrazol-2-yl-1-aza-bicyclo[2.2.2]octane DMIH6JU MI TTQ3JTF DMIH6JU MN Muscarinic acetylcholine receptor M4 (CHRM4) DMIH6JU MT DTT DMIH6JU MA Inhibitor DMIH6JU RN Synthesis and muscarinic activities of quinuclidin-3-yltriazole and -tetrazole derivatives. J Med Chem. 1992 Apr 3;35(7):1280-90. DMIH6JU RU https://pubmed.ncbi.nlm.nih.gov/1560440 DMIH6JU DI DMIH6JU DMIH6JU DN 3-Tetrazol-2-yl-1-aza-bicyclo[2.2.2]octane DMIH6JU MI TTH18TF DMIH6JU MN Muscarinic acetylcholine receptor M5 (CHRM5) DMIH6JU MT DTT DMIH6JU MA Inhibitor DMIH6JU RN Synthesis and muscarinic activities of quinuclidin-3-yltriazole and -tetrazole derivatives. J Med Chem. 1992 Apr 3;35(7):1280-90. DMIH6JU RU https://pubmed.ncbi.nlm.nih.gov/1560440 DM2K59V DI DM2K59V DM2K59V DN 3'thiacytidine DM2K59V MI TT84ETX DM2K59V MN Human immunodeficiency virus Reverse transcriptase (HIV RT) DM2K59V MT DTT DM2K59V MA Inhibitor DM2K59V RN Current use of anti-HIV drugs in AIDS. J Antimicrob Chemother. 1993 Jul;32 Suppl A:133-8. DM2K59V RU https://pubmed.ncbi.nlm.nih.gov/8407695 DM9MFZ1 DI DM9MFZ1 DM9MFZ1 DN 3-Thiophen-3-yl-quinoline DM9MFZ1 MI TT8FYO9 DM9MFZ1 MN Platelet-derived growth factor receptor alpha (PDGFRA) DM9MFZ1 MT DTT DM9MFZ1 MA Inhibitor DM9MFZ1 RN A new series of PDGF receptor tyrosine kinase inhibitors: 3-substituted quinoline derivatives. J Med Chem. 1994 Jul 8;37(14):2129-37. DM9MFZ1 RU https://pubmed.ncbi.nlm.nih.gov/8035419 DM9MFZ1 DI DM9MFZ1 DM9MFZ1 DN 3-Thiophen-3-yl-quinoline DM9MFZ1 MI TTI7421 DM9MFZ1 MN Platelet-derived growth factor receptor beta (PDGFRB) DM9MFZ1 MT DTT DM9MFZ1 MA Inhibitor DM9MFZ1 RN A new series of PDGF receptor tyrosine kinase inhibitors: 3-substituted quinoline derivatives. J Med Chem. 1994 Jul 8;37(14):2129-37. DM9MFZ1 RU https://pubmed.ncbi.nlm.nih.gov/8035419 DM5SM8X DI DM5SM8X DM5SM8X DN 3'-THIO-THYMIDINE-5'-PHOSPHATE DM5SM8X MI TT4NVEM DM5SM8X MN DNA topoisomerase II beta (TOP2B) DM5SM8X MT DTT DM5SM8X MA Inhibitor DM5SM8X RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DM5SM8X RU https://pubmed.ncbi.nlm.nih.gov/10592235 DMOQWDS DI DMOQWDS DMOQWDS DN 3-trans-p-coumaroyl maslinic acid DMOQWDS MI TTIU7X1 DMOQWDS MN Herpes simplex virus DNA polymerase UL30 (HSV UL30) DMOQWDS MT DTT DMOQWDS MA Inhibitor DMOQWDS RN DNA polymerase beta inhibitors from Tetracera boiviniana. J Nat Prod. 1999 Dec;62(12):1660-3. DMOQWDS RU https://pubmed.ncbi.nlm.nih.gov/10654414 DMI15VQ DI DMI15VQ DMI15VQ DN 4-((+/-)-(1H-imidazol-1-yl)-(E)-methylretinoate DMI15VQ MI TTD7Q0R DMI15VQ MN Cytochrome P450 26 (CYP26A1) DMI15VQ MT DTT DMI15VQ MA Inhibitor DMI15VQ RN Novel retinoic acid metabolism blocking agents endowed with multiple biological activities are efficient growth inhibitors of human breast and pros... J Med Chem. 2004 Dec 30;47(27):6716-29. DMI15VQ RU https://pubmed.ncbi.nlm.nih.gov/15615521 DMKYB4D DI DMKYB4D DMKYB4D DN 4-((+/-)-(1H-imidazol-1-yl)-(E)-retinoic acid DMKYB4D MI TTD7Q0R DMKYB4D MN Cytochrome P450 26 (CYP26A1) DMKYB4D MT DTT DMKYB4D MA Inhibitor DMKYB4D RN Novel retinoic acid metabolism blocking agents endowed with multiple biological activities are efficient growth inhibitors of human breast and pros... J Med Chem. 2004 Dec 30;47(27):6716-29. DMKYB4D RU https://pubmed.ncbi.nlm.nih.gov/15615521 DMDHV0N DI DMDHV0N DMDHV0N DN 4-((1H-imidazol-1-yl)methyl)-2H-chromen-2-one DMDHV0N MI TTSZLWK DMDHV0N MN Aromatase (CYP19A1) DMDHV0N MT DTT DMDHV0N MA Inhibitor DMDHV0N RN Fast three dimensional pharmacophore virtual screening of new potent non-steroid aromatase inhibitors. J Med Chem. 2009 Jan 8;52(1):143-50. DMDHV0N RU https://pubmed.ncbi.nlm.nih.gov/19072235 DMFUBRC DI DMFUBRC DMFUBRC DN 4-((1H-imidazol-1-yl)methyl)benzonitrile DMFUBRC MI TTSZLWK DMFUBRC MN Aromatase (CYP19A1) DMFUBRC MT DTT DMFUBRC MA Inhibitor DMFUBRC RN Fadrozole hydrochloride: a potent, selective, nonsteroidal inhibitor of aromatase for the treatment of estrogen-dependent disease. J Med Chem. 1991 Feb;34(2):725-36. DMFUBRC RU https://pubmed.ncbi.nlm.nih.gov/1825337 DMFUBRC DI DMFUBRC DMFUBRC DN 4-((1H-imidazol-1-yl)methyl)benzonitrile DMFUBRC MI TTIQUX7 DMFUBRC MN Steroid 11-beta-hydroxylase (CYP11B1) DMFUBRC MT DTT DMFUBRC MA Inhibitor DMFUBRC RN Synthesis, biological evaluation, and molecular modeling of 1-benzyl-1H-imidazoles as selective inhibitors of aldosterone synthase (CYP11B2). J Med Chem. 2010 Feb 25;53(4):1712-25. DMFUBRC RU https://pubmed.ncbi.nlm.nih.gov/20121113 DMFUBRC DI DMFUBRC DMFUBRC DN 4-((1H-imidazol-1-yl)methyl)benzonitrile DMFUBRC MI TTRA5BZ DMFUBRC MN Steroid 17-alpha-monooxygenase (S17AH) DMFUBRC MT DTT DMFUBRC MA Inhibitor DMFUBRC RN Synthesis and biochemical evaluation of a range of potent benzyl imidazole-based compounds as potential inhibitors of the enzyme complex 17alpha-hy... Bioorg Med Chem Lett. 2006 Aug 1;16(15):4011-5. DMFUBRC RU https://pubmed.ncbi.nlm.nih.gov/16750362 DMYDGH4 DI DMYDGH4 DMYDGH4 DN 4-((1H-imidazol-1-yl)methyl)phenol DMYDGH4 MI TTRA5BZ DMYDGH4 MN Steroid 17-alpha-monooxygenase (S17AH) DMYDGH4 MT DTT DMYDGH4 MA Inhibitor DMYDGH4 RN Synthesis and biochemical evaluation of a range of (4-substituted phenyl)sulfonate derivatives of 4-hydroxybenzyl imidazole-based compounds as pote... Bioorg Med Chem Lett. 2010 Sep 1;20(17):5345-8. DMYDGH4 RU https://pubmed.ncbi.nlm.nih.gov/20675132 DMX2QD5 DI DMX2QD5 DMX2QD5 DN 4-((1H-imidazol-4-yl)methyl)-1-heptylpiperidine DMX2QD5 MI TT9JNIC DMX2QD5 MN Histamine H3 receptor (H3R) DMX2QD5 MT DTT DMX2QD5 MA Inhibitor DMX2QD5 RN Novel histamine H3 receptor antagonists based on the 4-[(1H-imidazol-4-yl)methyl]piperidine scaffold. Bioorg Med Chem Lett. 2006 Jan 15;16(2):395-9. DMX2QD5 RU https://pubmed.ncbi.nlm.nih.gov/16246552 DMRYWSN DI DMRYWSN DMRYWSN DN 4-((1H-Imidazol-4-yl)methyl)-1-phenylpiperidine DMRYWSN MI TT9JNIC DMRYWSN MN Histamine H3 receptor (H3R) DMRYWSN MT DTT DMRYWSN MA Inhibitor DMRYWSN RN Synthesis and structure-activity relationships of N-aryl-piperidine derivatives as potent (partial) agonists for human histamine H3 receptor. Bioorg Med Chem. 2010 Jul 15;18(14):5441-8. DMRYWSN RU https://pubmed.ncbi.nlm.nih.gov/20541426 DMLV59R DI DMLV59R DMLV59R DN 4-((1H-indazol-6-ylamino)methyl)benzene-1,2-diol DMLV59R MI TTCBFJO DMLV59R MN Insulin receptor (INSR) DMLV59R MT DTT DMLV59R MA Inhibitor DMLV59R RN ATP non-competitive IGF-1 receptor kinase inhibitors as lead anti-neoplastic and anti-papilloma agents. Eur J Pharmacol. 2007 May 7;562(1-2):1-11. DMLV59R RU https://pubmed.ncbi.nlm.nih.gov/17376430 DMLV59R DI DMLV59R DMLV59R DN 4-((1H-indazol-6-ylamino)methyl)benzene-1,2-diol DMLV59R MI TTHRID2 DMLV59R MN Insulin-like growth factor I receptor (IGF1R) DMLV59R MT DTT DMLV59R MA Inhibitor DMLV59R RN ATP non-competitive IGF-1 receptor kinase inhibitors as lead anti-neoplastic and anti-papilloma agents. Eur J Pharmacol. 2007 May 7;562(1-2):1-11. DMLV59R RU https://pubmed.ncbi.nlm.nih.gov/17376430 DMRWZ6T DI DMRWZ6T DMRWZ6T DN 4-((1H-indol-1-yl)methyl)benzenamine DMRWZ6T MI TTJS8PY DMRWZ6T MN 5-HT 6 receptor (HTR6) DMRWZ6T MT DTT DMRWZ6T MA Inhibitor DMRWZ6T RN Further studies on the binding of N1-substituted tryptamines at h5-HT6 receptors. Bioorg Med Chem Lett. 2007 Mar 15;17(6):1691-4. DMRWZ6T RU https://pubmed.ncbi.nlm.nih.gov/17239595 DMCRWTH DI DMCRWTH DMCRWTH DN 4'-((2-butylbenzofuran-3-yl)methyl)biphenyl-4-ol DMCRWTH MI TTELIN2 DMCRWTH MN PTPN1 messenger RNA (PTPN1 mRNA) DMCRWTH MT DTT DMCRWTH MA Inhibitor DMCRWTH RN Synthesis, activity and molecular modeling of a new series of chromones as low molecular weight protein tyrosine phosphatase inhibitors. Bioorg Med Chem. 2009 Apr 1;17(7):2658-72. DMCRWTH RU https://pubmed.ncbi.nlm.nih.gov/19297174 DMJN2OW DI DMJN2OW DMJN2OW DN 4-((2R,3S)-2-Methyl-pyrrolidin-3-yl)-1H-imidazole DMJN2OW MI TT9JNIC DMJN2OW MN Histamine H3 receptor (H3R) DMJN2OW MT DTT DMJN2OW MA Inhibitor DMJN2OW RN A novel pyrrolidine analog of histamine as a potent, highly selective histamine H3 receptor agonist. J Med Chem. 1995 May 12;38(10):1593-9. DMJN2OW RU https://pubmed.ncbi.nlm.nih.gov/7752184 DM8WCJK DI DM8WCJK DM8WCJK DN 4-((2S,3R)-2-Methyl-pyrrolidin-3-yl)-1H-imidazole DM8WCJK MI TT9JNIC DM8WCJK MN Histamine H3 receptor (H3R) DM8WCJK MT DTT DM8WCJK MA Inhibitor DM8WCJK RN A novel pyrrolidine analog of histamine as a potent, highly selective histamine H3 receptor agonist. J Med Chem. 1995 May 12;38(10):1593-9. DM8WCJK RU https://pubmed.ncbi.nlm.nih.gov/7752184 DMHN5OL DI DMHN5OL DMHN5OL DN 4-((3',4'-Difluorobiphenyl-4-yl)methyl)pyridine DMHN5OL MI TTIQUX7 DMHN5OL MN Steroid 11-beta-hydroxylase (CYP11B1) DMHN5OL MT DTT DMHN5OL MA Inhibitor DMHN5OL RN Replacement of imidazolyl by pyridyl in biphenylmethylenes results in selective CYP17 and dual CYP17/CYP11B1 inhibitors for the treatment of prosta... J Med Chem. 2010 Aug 12;53(15):5749-58. DMHN5OL RU https://pubmed.ncbi.nlm.nih.gov/20684610 DMHN5OL DI DMHN5OL DMHN5OL DN 4-((3',4'-Difluorobiphenyl-4-yl)methyl)pyridine DMHN5OL MI TTRA5BZ DMHN5OL MN Steroid 17-alpha-monooxygenase (S17AH) DMHN5OL MT DTT DMHN5OL MA Inhibitor DMHN5OL RN Replacement of imidazolyl by pyridyl in biphenylmethylenes results in selective CYP17 and dual CYP17/CYP11B1 inhibitors for the treatment of prosta... J Med Chem. 2010 Aug 12;53(15):5749-58. DMHN5OL RU https://pubmed.ncbi.nlm.nih.gov/20684610 DM5EP3V DI DM5EP3V DM5EP3V DN 4-((4-hydroxyphenyl)diazenyl)benzenesulfonamide DM5EP3V MI TTANPDJ DM5EP3V MN Carbonic anhydrase II (CA-II) DM5EP3V MT DTT DM5EP3V MA Inhibitor DM5EP3V RN Carbonic anhydrase inhibitors. Inhibition of the Rv1284 and Rv3273 beta-carbonic anhydrases from Mycobacterium tuberculosis with diazenylbenzenesul... Bioorg Med Chem Lett. 2009 Sep 1;19(17):4929-32. DM5EP3V RU https://pubmed.ncbi.nlm.nih.gov/19651511 DM5EP3V DI DM5EP3V DM5EP3V DN 4-((4-hydroxyphenyl)diazenyl)benzenesulfonamide DM5EP3V MI TT2LVK8 DM5EP3V MN Carbonic anhydrase IX (CA-IX) DM5EP3V MT DTT DM5EP3V MA Inhibitor DM5EP3V RN Carbonic anhydrase inhibitors. Diazenylbenzenesulfonamides are potent and selective inhibitors of the tumor-associated isozymes IX and XII over the... Bioorg Med Chem. 2009 Oct 15;17(20):7093-9. DM5EP3V RU https://pubmed.ncbi.nlm.nih.gov/19773173 DM5EP3V DI DM5EP3V DM5EP3V DN 4-((4-hydroxyphenyl)diazenyl)benzenesulfonamide DM5EP3V MI TTSYM0R DM5EP3V MN Carbonic anhydrase XII (CA-XII) DM5EP3V MT DTT DM5EP3V MA Inhibitor DM5EP3V RN Carbonic anhydrase inhibitors. Diazenylbenzenesulfonamides are potent and selective inhibitors of the tumor-associated isozymes IX and XII over the... Bioorg Med Chem. 2009 Oct 15;17(20):7093-9. DM5EP3V RU https://pubmed.ncbi.nlm.nih.gov/19773173 DMNAT1D DI DMNAT1D DMNAT1D DN 4-((4-methoxyphenyl)diazenyl)benzenesulfonamide DMNAT1D MI TTVKILB DMNAT1D MN Prostaglandin G/H synthase 2 (COX-2) DMNAT1D MT DTT DMNAT1D MA Inhibitor DMNAT1D RN Selective COX-2 inhibitors. Part 1: synthesis and biological evaluation of phenylazobenzenesulfonamides. Bioorg Med Chem Lett. 2006 Sep 1;16(17):4440-3. DMNAT1D RU https://pubmed.ncbi.nlm.nih.gov/16814546 DM6R43J DI DM6R43J DM6R43J DN 4-((benzylideneamino)methyl)benzenesulfonamide DM6R43J MI TTANPDJ DM6R43J MN Carbonic anhydrase II (CA-II) DM6R43J MT DTT DM6R43J MA Inhibitor DM6R43J RN Carbonic anhydrase II-induced selection of inhibitors from a dynamic combinatorial library of Schiff's bases. Bioorg Med Chem Lett. 2009 Nov 1;19(21):6014-7. DM6R43J RU https://pubmed.ncbi.nlm.nih.gov/19796939 DMDOJ4E DI DMDOJ4E DMDOJ4E DN 4-((E)-1-Naphthalen-1-yl-propenyl)-1H-imidazole DMDOJ4E MI TTNGILX DMDOJ4E MN Adrenergic receptor alpha-1A (ADRA1A) DMDOJ4E MT DTT DMDOJ4E MA Inhibitor DMDOJ4E RN Medetomidine analogs as alpha 2-adrenergic ligands. 2. Design, synthesis, and biological activity of conformationally restricted naphthalene deriva... J Med Chem. 1996 Jul 19;39(15):3001-13. DMDOJ4E RU https://pubmed.ncbi.nlm.nih.gov/8709134 DMDOJ4E DI DMDOJ4E DMDOJ4E DN 4-((E)-1-Naphthalen-1-yl-propenyl)-1H-imidazole DMDOJ4E MI TTBRKXS DMDOJ4E MN Adrenergic receptor alpha-1B (ADRA1B) DMDOJ4E MT DTT DMDOJ4E MA Inhibitor DMDOJ4E RN Medetomidine analogs as alpha 2-adrenergic ligands. 2. Design, synthesis, and biological activity of conformationally restricted naphthalene deriva... J Med Chem. 1996 Jul 19;39(15):3001-13. DMDOJ4E RU https://pubmed.ncbi.nlm.nih.gov/8709134 DMDOJ4E DI DMDOJ4E DMDOJ4E DN 4-((E)-1-Naphthalen-1-yl-propenyl)-1H-imidazole DMDOJ4E MI TT34BHT DMDOJ4E MN Adrenergic receptor alpha-1D (ADRA1D) DMDOJ4E MT DTT DMDOJ4E MA Inhibitor DMDOJ4E RN Medetomidine analogs as alpha 2-adrenergic ligands. 2. Design, synthesis, and biological activity of conformationally restricted naphthalene deriva... J Med Chem. 1996 Jul 19;39(15):3001-13. DMDOJ4E RU https://pubmed.ncbi.nlm.nih.gov/8709134 DM52Y3Q DI DM52Y3Q DM52Y3Q DN 4-((naphthalen-2-ylamino)methyl)benzene-1,2-diol DM52Y3Q MI TTCBFJO DM52Y3Q MN Insulin receptor (INSR) DM52Y3Q MT DTT DM52Y3Q MA Inhibitor DM52Y3Q RN ATP non-competitive IGF-1 receptor kinase inhibitors as lead anti-neoplastic and anti-papilloma agents. Eur J Pharmacol. 2007 May 7;562(1-2):1-11. DM52Y3Q RU https://pubmed.ncbi.nlm.nih.gov/17376430 DM52Y3Q DI DM52Y3Q DM52Y3Q DN 4-((naphthalen-2-ylamino)methyl)benzene-1,2-diol DM52Y3Q MI TTHRID2 DM52Y3Q MN Insulin-like growth factor I receptor (IGF1R) DM52Y3Q MT DTT DM52Y3Q MA Inhibitor DM52Y3Q RN ATP non-competitive IGF-1 receptor kinase inhibitors as lead anti-neoplastic and anti-papilloma agents. Eur J Pharmacol. 2007 May 7;562(1-2):1-11. DM52Y3Q RU https://pubmed.ncbi.nlm.nih.gov/17376430 DMIQHYZ DI DMIQHYZ DMIQHYZ DN 4-((naphthalen-2-yloxy)methyl)piperidine DMIQHYZ MI TTPC4TU DMIQHYZ MN 5-HT 3A receptor (HTR3A) DMIQHYZ MT DTT DMIQHYZ MA Inhibitor DMIQHYZ RN Design and optimization of selective serotonin re-uptake inhibitors with high synthetic accessibility. Part 1. Bioorg Med Chem Lett. 2009 Apr 15;19(8):2329-32. DMIQHYZ RU https://pubmed.ncbi.nlm.nih.gov/19282174 DMIQHYZ DI DMIQHYZ DMIQHYZ DN 4-((naphthalen-2-yloxy)methyl)piperidine DMIQHYZ MI TTAWNKZ DMIQHYZ MN Norepinephrine transporter (NET) DMIQHYZ MT DTT DMIQHYZ MA Inhibitor DMIQHYZ RN Design and optimization of selective serotonin re-uptake inhibitors with high synthetic accessibility. Part 1. Bioorg Med Chem Lett. 2009 Apr 15;19(8):2329-32. DMIQHYZ RU https://pubmed.ncbi.nlm.nih.gov/19282174 DMIQHYZ DI DMIQHYZ DMIQHYZ DN 4-((naphthalen-2-yloxy)methyl)piperidine DMIQHYZ MI TT3ROYC DMIQHYZ MN Serotonin transporter (SERT) DMIQHYZ MT DTT DMIQHYZ MA Inhibitor DMIQHYZ RN Design and optimization of selective serotonin re-uptake inhibitors with high synthetic accessibility. Part 1. Bioorg Med Chem Lett. 2009 Apr 15;19(8):2329-32. DMIQHYZ RU https://pubmed.ncbi.nlm.nih.gov/19282174 DMIQHYZ DI DMIQHYZ DMIQHYZ DN 4-((naphthalen-2-yloxy)methyl)piperidine DMIQHYZ MI TTQ6VDM DMIQHYZ MN Voltage-gated potassium channel Kv11.1 (KCNH2) DMIQHYZ MT DTT DMIQHYZ MA Inhibitor DMIQHYZ RN Design and optimization of selective serotonin re-uptake inhibitors with high synthetic accessibility. Part 1. Bioorg Med Chem Lett. 2009 Apr 15;19(8):2329-32. DMIQHYZ RU https://pubmed.ncbi.nlm.nih.gov/19282174 DM7X2AY DI DM7X2AY DM7X2AY DN 4-((pyridin-4-ylthio)methyl)benzene-1,2-diol DM7X2AY MI TT6804T DM7X2AY MN MIF messenger RNA (MIF mRNA) DM7X2AY MT DTT DM7X2AY MA Inhibitor DM7X2AY RN Classification of chemical compounds by protein-compound docking for use in designing a focused library. J Med Chem. 2006 Jan 26;49(2):523-33. DM7X2AY RU https://pubmed.ncbi.nlm.nih.gov/16420039 DM1UK3G DI DM1UK3G DM1UK3G DN 4-((Z)-1-Naphthalen-1-yl-propenyl)-1H-imidazole DM1UK3G MI TTNGILX DM1UK3G MN Adrenergic receptor alpha-1A (ADRA1A) DM1UK3G MT DTT DM1UK3G MA Inhibitor DM1UK3G RN Medetomidine analogs as alpha 2-adrenergic ligands. 2. Design, synthesis, and biological activity of conformationally restricted naphthalene deriva... J Med Chem. 1996 Jul 19;39(15):3001-13. DM1UK3G RU https://pubmed.ncbi.nlm.nih.gov/8709134 DM1UK3G DI DM1UK3G DM1UK3G DN 4-((Z)-1-Naphthalen-1-yl-propenyl)-1H-imidazole DM1UK3G MI TTBRKXS DM1UK3G MN Adrenergic receptor alpha-1B (ADRA1B) DM1UK3G MT DTT DM1UK3G MA Inhibitor DM1UK3G RN Medetomidine analogs as alpha 2-adrenergic ligands. 2. Design, synthesis, and biological activity of conformationally restricted naphthalene deriva... J Med Chem. 1996 Jul 19;39(15):3001-13. DM1UK3G RU https://pubmed.ncbi.nlm.nih.gov/8709134 DM1UK3G DI DM1UK3G DM1UK3G DN 4-((Z)-1-Naphthalen-1-yl-propenyl)-1H-imidazole DM1UK3G MI TT34BHT DM1UK3G MN Adrenergic receptor alpha-1D (ADRA1D) DM1UK3G MT DTT DM1UK3G MA Inhibitor DM1UK3G RN Medetomidine analogs as alpha 2-adrenergic ligands. 2. Design, synthesis, and biological activity of conformationally restricted naphthalene deriva... J Med Chem. 1996 Jul 19;39(15):3001-13. DM1UK3G RU https://pubmed.ncbi.nlm.nih.gov/8709134 DMEW1CP DI DMEW1CP DMEW1CP DN 4'-(1-(pyridin-4-yl)propyl)biphenyl-3-ol DMEW1CP MI TTRA5BZ DMEW1CP MN Steroid 17-alpha-monooxygenase (S17AH) DMEW1CP MT DTT DMEW1CP MA Inhibitor DMEW1CP RN Isopropylidene substitution increases activity and selectivity of biphenylmethylene 4-pyridine type CYP17 inhibitors. J Med Chem. 2010 Jul 8;53(13):5049-53. DMEW1CP RU https://pubmed.ncbi.nlm.nih.gov/20550118 DMV4QRF DI DMV4QRF DMV4QRF DN 4-(1,1-dimethyl-heptyl)-2'-methoxy-biphenyl-2-ol DMV4QRF MI TT6OEDT DMV4QRF MN Cannabinoid receptor 1 (CB1) DMV4QRF MT DTT DMV4QRF MA Inhibitor DMV4QRF RN Biaryl cannabinoid mimetics--synthesis and structure-activity relationship. Bioorg Med Chem Lett. 2007 Jul 1;17(13):3652-6. DMV4QRF RU https://pubmed.ncbi.nlm.nih.gov/17507224 DMV4QRF DI DMV4QRF DMV4QRF DN 4-(1,1-dimethyl-heptyl)-2'-methoxy-biphenyl-2-ol DMV4QRF MI TTMSFAW DMV4QRF MN Cannabinoid receptor 2 (CB2) DMV4QRF MT DTT DMV4QRF MA Inhibitor DMV4QRF RN Biaryl cannabinoid mimetics--synthesis and structure-activity relationship. Bioorg Med Chem Lett. 2007 Jul 1;17(13):3652-6. DMV4QRF RU https://pubmed.ncbi.nlm.nih.gov/17507224 DMUMD8L DI DMUMD8L DMUMD8L DN 4'-(1,1-dimethyl-heptyl)-3,5-dimethyl-biphenyl DMUMD8L MI TTMSFAW DMUMD8L MN Cannabinoid receptor 2 (CB2) DMUMD8L MT DTT DMUMD8L MA Inhibitor DMUMD8L RN Biaryl cannabinoid mimetics--synthesis and structure-activity relationship. Bioorg Med Chem Lett. 2007 Jul 1;17(13):3652-6. DMUMD8L RU https://pubmed.ncbi.nlm.nih.gov/17507224 DM5BN41 DI DM5BN41 DM5BN41 DN 4-(1,1-dimethyl-heptyl)-3'-methoxy-biphenyl-2-ol DM5BN41 MI TT6OEDT DM5BN41 MN Cannabinoid receptor 1 (CB1) DM5BN41 MT DTT DM5BN41 MA Inhibitor DM5BN41 RN Biaryl cannabinoid mimetics--synthesis and structure-activity relationship. Bioorg Med Chem Lett. 2007 Jul 1;17(13):3652-6. DM5BN41 RU https://pubmed.ncbi.nlm.nih.gov/17507224 DM5BN41 DI DM5BN41 DM5BN41 DN 4-(1,1-dimethyl-heptyl)-3'-methoxy-biphenyl-2-ol DM5BN41 MI TTMSFAW DM5BN41 MN Cannabinoid receptor 2 (CB2) DM5BN41 MT DTT DM5BN41 MA Inhibitor DM5BN41 RN Biaryl cannabinoid mimetics--synthesis and structure-activity relationship. Bioorg Med Chem Lett. 2007 Jul 1;17(13):3652-6. DM5BN41 RU https://pubmed.ncbi.nlm.nih.gov/17507224 DMG4HO3 DI DMG4HO3 DMG4HO3 DN 4-(1,2,3-thiadiazol-4-yl)phenyl butylcarbamate DMG4HO3 MI TTDP1UC DMG4HO3 MN Fatty acid amide hydrolase (FAAH) DMG4HO3 MT DTT DMG4HO3 MA Inhibitor DMG4HO3 RN The synthesis and biological evaluation of para-substituted phenolic N-alkyl carbamates as endocannabinoid hydrolyzing enzyme inhibitors. Eur J Med Chem. 2009 Jul;44(7):2994-3008. DMG4HO3 RU https://pubmed.ncbi.nlm.nih.gov/19232787 DMSFGRI DI DMSFGRI DMSFGRI DN 4-(1,2,3-thiadiazol-4-yl)phenyl hexylcarbamate DMSFGRI MI TTDP1UC DMSFGRI MN Fatty acid amide hydrolase (FAAH) DMSFGRI MT DTT DMSFGRI MA Inhibitor DMSFGRI RN The synthesis and biological evaluation of para-substituted phenolic N-alkyl carbamates as endocannabinoid hydrolyzing enzyme inhibitors. Eur J Med Chem. 2009 Jul;44(7):2994-3008. DMSFGRI RU https://pubmed.ncbi.nlm.nih.gov/19232787 DMJDW50 DI DMJDW50 DMJDW50 DN 4-(1,2-Diphenyl-but-1-enyl)-phenol DMJDW50 MI TTZAYWL DMJDW50 MN Estrogen receptor (ESR) DMJDW50 MT DTT DMJDW50 MA Inhibitor DMJDW50 RN Investigations on estrogen receptor binding. The estrogenic, antiestrogenic, and cytotoxic properties of C2-alkyl-substituted 1,1-bis(4-hydroxyphen... J Med Chem. 2002 Nov 21;45(24):5358-64. DMJDW50 RU https://pubmed.ncbi.nlm.nih.gov/12431063 DM1SP36 DI DM1SP36 DM1SP36 DN 4-(10H-Anthracen-9-ylidene)-1-methyl-piperidine DM1SP36 MI TTJQOD7 DM1SP36 MN 5-HT 2A receptor (HTR2A) DM1SP36 MT DTT DM1SP36 MA Inhibitor DM1SP36 RN Exploring the relationship between binding modes of 9-(aminomethyl)-9,10-dihydroanthracene and cyproheptadine analogues at the 5-HT2A serotonin rec... Bioorg Med Chem Lett. 2001 Feb 26;11(4):563-6. DM1SP36 RU https://pubmed.ncbi.nlm.nih.gov/11229772 DMNV9H5 DI DMNV9H5 DMNV9H5 DN 4-(1-benzyl-7-chloro-1H-indazol-3-yl)phenol DMNV9H5 MI TTZAYWL DMNV9H5 MN Estrogen receptor (ESR) DMNV9H5 MT DTT DMNV9H5 MA Inhibitor DMNV9H5 RN Synthesis and activity of substituted 4-(indazol-3-yl)phenols as pathway-selective estrogen receptor ligands useful in the treatment of rheumatoid ... J Med Chem. 2004 Dec 16;47(26):6435-8. DMNV9H5 RU https://pubmed.ncbi.nlm.nih.gov/15588074 DMS1OYA DI DMS1OYA DMS1OYA DN 4-(1-butyl-7-chloro-1H-indazol-3-yl)phenol DMS1OYA MI TTZAYWL DMS1OYA MN Estrogen receptor (ESR) DMS1OYA MT DTT DMS1OYA MA Inhibitor DMS1OYA RN Synthesis and activity of substituted 4-(indazol-3-yl)phenols as pathway-selective estrogen receptor ligands useful in the treatment of rheumatoid ... J Med Chem. 2004 Dec 16;47(26):6435-8. DMS1OYA RU https://pubmed.ncbi.nlm.nih.gov/15588074 DM3NEYB DI DM3NEYB DM3NEYB DN 4-(1-cyclopentyl-7-fluoro-1H-indazol-3-yl)phenol DM3NEYB MI TTZAYWL DM3NEYB MN Estrogen receptor (ESR) DM3NEYB MT DTT DM3NEYB MA Inhibitor DM3NEYB RN Synthesis and activity of substituted 4-(indazol-3-yl)phenols as pathway-selective estrogen receptor ligands useful in the treatment of rheumatoid ... J Med Chem. 2004 Dec 16;47(26):6435-8. DM3NEYB RU https://pubmed.ncbi.nlm.nih.gov/15588074 DMFWVJI DI DMFWVJI DMFWVJI DN 4-(1H-1,2,3-triazol-5-yl)pyridine DMFWVJI MI TTZJYKH DMFWVJI MN Indoleamine 2,3-dioxygenase 1 (IDO1) DMFWVJI MT DTT DMFWVJI MA Inhibitor DMFWVJI RN Rational design of indoleamine 2,3-dioxygenase inhibitors. J Med Chem. 2010 Feb 11;53(3):1172-89. DMFWVJI RU https://pubmed.ncbi.nlm.nih.gov/20055453 DM5JDYO DI DM5JDYO DM5JDYO DN 4-(1H-IMIDAZOL-1-YL)PHENOL DM5JDYO MI TTF10I9 DM5JDYO MN Nitric-oxide synthase inducible (NOS2) DM5JDYO MT DTT DM5JDYO MA Inhibitor DM5JDYO RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DM5JDYO RU https://pubmed.ncbi.nlm.nih.gov/10592235 DMMJI4R DI DMMJI4R DMMJI4R DN 4-(1H-Inden-1-ylmethyl)-phenylamine DMMJI4R MI TTJS8PY DMMJI4R MN 5-HT 6 receptor (HTR6) DMMJI4R MT DTT DMMJI4R MA Inhibitor DMMJI4R RN Binding of isotryptamines and indenes at h5-HT6 serotonin receptors. Bioorg Med Chem Lett. 2005 Apr 15;15(8):1987-91. DMMJI4R RU https://pubmed.ncbi.nlm.nih.gov/15808453 DMY5QBF DI DMY5QBF DMY5QBF DN 4-(1H-indol-1-ylsulfonyl)benzenamine DMY5QBF MI TTJS8PY DMY5QBF MN 5-HT 6 receptor (HTR6) DMY5QBF MT DTT DMY5QBF MA Inhibitor DMY5QBF RN Binding of amine-substituted N1-benzenesulfonylindoles at human 5-HT6 serotonin receptors. Bioorg Med Chem Lett. 2005 Dec 1;15(23):5298-302. DMY5QBF RU https://pubmed.ncbi.nlm.nih.gov/16183286 DM9FKSM DI DM9FKSM DM9FKSM DN 4-(1H-indol-3-yl)-1-morpholinobutan-1-one DM9FKSM MI TT2J34L DM9FKSM MN Arachidonate 5-lipoxygenase (5-LOX) DM9FKSM MT DTT DM9FKSM MA Inhibitor DM9FKSM RN Indole derivatives as potent inhibitors of 5-lipoxygenase: design, synthesis, biological evaluation, and molecular modeling. Bioorg Med Chem Lett. 2007 May 1;17(9):2414-20. DM9FKSM RU https://pubmed.ncbi.nlm.nih.gov/17336065 DM7Y1ZD DI DM7Y1ZD DM7Y1ZD DN 4-(1H-indol-3-yl)-N,N-dimethylcyclohex-3-enamine DM7Y1ZD MI TTVBI8W DM7Y1ZD MN Dopamine transporter (DAT) DM7Y1ZD MT DTT DM7Y1ZD MA Inhibitor DM7Y1ZD RN Conformationally restricted homotryptamines 3. Indole tetrahydropyridines and cyclohexenylamines as selective serotonin reuptake inhibitors. Bioorg Med Chem Lett. 2007 Jun 1;17(11):3099-104. DM7Y1ZD RU https://pubmed.ncbi.nlm.nih.gov/17391962 DM7Y1ZD DI DM7Y1ZD DM7Y1ZD DN 4-(1H-indol-3-yl)-N,N-dimethylcyclohex-3-enamine DM7Y1ZD MI TTAWNKZ DM7Y1ZD MN Norepinephrine transporter (NET) DM7Y1ZD MT DTT DM7Y1ZD MA Inhibitor DM7Y1ZD RN Conformationally restricted homotryptamines 3. Indole tetrahydropyridines and cyclohexenylamines as selective serotonin reuptake inhibitors. Bioorg Med Chem Lett. 2007 Jun 1;17(11):3099-104. DM7Y1ZD RU https://pubmed.ncbi.nlm.nih.gov/17391962 DM7Y1ZD DI DM7Y1ZD DM7Y1ZD DN 4-(1H-indol-3-yl)-N,N-dimethylcyclohex-3-enamine DM7Y1ZD MI TT3ROYC DM7Y1ZD MN Serotonin transporter (SERT) DM7Y1ZD MT DTT DM7Y1ZD MA Inhibitor DM7Y1ZD RN Conformationally restricted homotryptamines 3. Indole tetrahydropyridines and cyclohexenylamines as selective serotonin reuptake inhibitors. Bioorg Med Chem Lett. 2007 Jun 1;17(11):3099-104. DM7Y1ZD RU https://pubmed.ncbi.nlm.nih.gov/17391962 DMK5CJO DI DMK5CJO DMK5CJO DN 4-(1H-Indol-3-ylmethyl)-phenylamine DMK5CJO MI TTJS8PY DMK5CJO MN 5-HT 6 receptor (HTR6) DMK5CJO MT DTT DMK5CJO MA Inhibitor DMK5CJO RN Binding of isotryptamines and indenes at h5-HT6 serotonin receptors. Bioorg Med Chem Lett. 2005 Apr 15;15(8):1987-91. DMK5CJO RU https://pubmed.ncbi.nlm.nih.gov/15808453 DMQVOSU DI DMQVOSU DMQVOSU DN 4-(1H-indol-4-yloxy)-1-(isopropylamino)butan-2-ol DMQVOSU MI TTSQIFT DMQVOSU MN 5-HT 1A receptor (HTR1A) DMQVOSU MT DTT DMQVOSU MA Inhibitor DMQVOSU RN Indoloxypropanolamine analogues as 5-HT(1A) receptor antagonists. Bioorg Med Chem Lett. 2007 Oct 15;17(20):5600-4. DMQVOSU RU https://pubmed.ncbi.nlm.nih.gov/17804228 DMAU0SF DI DMAU0SF DMAU0SF DN 4-(1H-indol-5-ylamino)-5-styrylnicotinonitrile DMAU0SF MI TT1MS7X DMAU0SF MN PKC-theta messenger RNA (PRKCQ mRNA) DMAU0SF MT DTT DMAU0SF MA Inhibitor DMAU0SF RN First generation 5-vinyl-3-pyridinecarbonitrile PKCtheta inhibitors. Bioorg Med Chem Lett. 2009 Oct 15;19(20):5829-32. DMAU0SF RU https://pubmed.ncbi.nlm.nih.gov/19762237 DMH360U DI DMH360U DMH360U DN 4-(1H-indol-5-yloxy)-5-styrylnicotinonitrile DMH360U MI TT1MS7X DMH360U MN PKC-theta messenger RNA (PRKCQ mRNA) DMH360U MT DTT DMH360U MA Inhibitor DMH360U RN First generation 5-vinyl-3-pyridinecarbonitrile PKCtheta inhibitors. Bioorg Med Chem Lett. 2009 Oct 15;19(20):5829-32. DMH360U RU https://pubmed.ncbi.nlm.nih.gov/19762237 DMB07TU DI DMB07TU DMB07TU DN 4-(1H-indol-6-ylamino)-5-styrylnicotinonitrile DMB07TU MI TT1MS7X DMB07TU MN PKC-theta messenger RNA (PRKCQ mRNA) DMB07TU MT DTT DMB07TU MA Inhibitor DMB07TU RN First generation 5-vinyl-3-pyridinecarbonitrile PKCtheta inhibitors. Bioorg Med Chem Lett. 2009 Oct 15;19(20):5829-32. DMB07TU RU https://pubmed.ncbi.nlm.nih.gov/19762237 DM9MPHF DI DM9MPHF DM9MPHF DN 4-(1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridine DM9MPHF MI TT9RTBL DM9MPHF MN Aurora B messenger RNA (AURKB mRNA) DM9MPHF MT DTT DM9MPHF MA Inhibitor DM9MPHF RN Discovery of a new series of Aurora inhibitors through truncation of GSK1070916. Bioorg Med Chem Lett. 2010 Apr 15;20(8):2552-5. DM9MPHF RU https://pubmed.ncbi.nlm.nih.gov/20335034 DM9MPHF DI DM9MPHF DM9MPHF DN 4-(1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridine DM9MPHF MI TTPS3C0 DM9MPHF MN Aurora kinase A (AURKA) DM9MPHF MT DTT DM9MPHF MA Inhibitor DM9MPHF RN Discovery of a new series of Aurora inhibitors through truncation of GSK1070916. Bioorg Med Chem Lett. 2010 Apr 15;20(8):2552-5. DM9MPHF RU https://pubmed.ncbi.nlm.nih.gov/20335034 DM08963 DI DM08963 DM08963 DN 4-(1-Imidazol-1-yl-vinyl)-benzonitrile DM08963 MI TTSZLWK DM08963 MN Aromatase (CYP19A1) DM08963 MT DTT DM08963 MA Inhibitor DM08963 RN Aromatase inhibitors: synthesis, biological activity, and binding mode of azole-type compounds. J Med Chem. 1993 May 14;36(10):1393-400. DM08963 RU https://pubmed.ncbi.nlm.nih.gov/8496907 DMFYBLH DI DMFYBLH DMFYBLH DN 4-(1-Naphthalen-1-yl-ethyl)-1H-imidazole DMFYBLH MI TTNGILX DMFYBLH MN Adrenergic receptor alpha-1A (ADRA1A) DMFYBLH MT DTT DMFYBLH MA Inhibitor DMFYBLH RN A structure-activity relationship study of benzylic modifications of 4-[1-(1-naphthyl)ethyl]-1H-imidazoles on alpha 1- and alpha 2-adrenergic recep... J Med Chem. 1994 Jul 22;37(15):2328-33. DMFYBLH RU https://pubmed.ncbi.nlm.nih.gov/7914537 DMFYBLH DI DMFYBLH DMFYBLH DN 4-(1-Naphthalen-1-yl-ethyl)-1H-imidazole DMFYBLH MI TTBRKXS DMFYBLH MN Adrenergic receptor alpha-1B (ADRA1B) DMFYBLH MT DTT DMFYBLH MA Inhibitor DMFYBLH RN A structure-activity relationship study of benzylic modifications of 4-[1-(1-naphthyl)ethyl]-1H-imidazoles on alpha 1- and alpha 2-adrenergic recep... J Med Chem. 1994 Jul 22;37(15):2328-33. DMFYBLH RU https://pubmed.ncbi.nlm.nih.gov/7914537 DMFYBLH DI DMFYBLH DMFYBLH DN 4-(1-Naphthalen-1-yl-ethyl)-1H-imidazole DMFYBLH MI TT34BHT DMFYBLH MN Adrenergic receptor alpha-1D (ADRA1D) DMFYBLH MT DTT DMFYBLH MA Inhibitor DMFYBLH RN A structure-activity relationship study of benzylic modifications of 4-[1-(1-naphthyl)ethyl]-1H-imidazoles on alpha 1- and alpha 2-adrenergic recep... J Med Chem. 1994 Jul 22;37(15):2328-33. DMFYBLH RU https://pubmed.ncbi.nlm.nih.gov/7914537 DMFYBLH DI DMFYBLH DMFYBLH DN 4-(1-Naphthalen-1-yl-ethyl)-1H-imidazole DMFYBLH MI TTWG9A4 DMFYBLH MN Adrenergic receptor alpha-2A (ADRA2A) DMFYBLH MT DTT DMFYBLH MA Inhibitor DMFYBLH RN A structure-activity relationship study of benzylic modifications of 4-[1-(1-naphthyl)ethyl]-1H-imidazoles on alpha 1- and alpha 2-adrenergic recep... J Med Chem. 1994 Jul 22;37(15):2328-33. DMFYBLH RU https://pubmed.ncbi.nlm.nih.gov/7914537 DMFYBLH DI DMFYBLH DMFYBLH DN 4-(1-Naphthalen-1-yl-ethyl)-1H-imidazole DMFYBLH MI TTWM4TY DMFYBLH MN Adrenergic receptor alpha-2B (ADRA2B) DMFYBLH MT DTT DMFYBLH MA Inhibitor DMFYBLH RN A structure-activity relationship study of benzylic modifications of 4-[1-(1-naphthyl)ethyl]-1H-imidazoles on alpha 1- and alpha 2-adrenergic recep... J Med Chem. 1994 Jul 22;37(15):2328-33. DMFYBLH RU https://pubmed.ncbi.nlm.nih.gov/7914537 DMFYBLH DI DMFYBLH DMFYBLH DN 4-(1-Naphthalen-1-yl-ethyl)-1H-imidazole DMFYBLH MI TT2NUT5 DMFYBLH MN Adrenergic receptor alpha-2C (ADRA2C) DMFYBLH MT DTT DMFYBLH MA Inhibitor DMFYBLH RN A structure-activity relationship study of benzylic modifications of 4-[1-(1-naphthyl)ethyl]-1H-imidazoles on alpha 1- and alpha 2-adrenergic recep... J Med Chem. 1994 Jul 22;37(15):2328-33. DMFYBLH RU https://pubmed.ncbi.nlm.nih.gov/7914537 DM64THP DI DM64THP DM64THP DN 4-(1-Naphthalen-1-yl-propyl)-1H-imidazole DM64THP MI TTNGILX DM64THP MN Adrenergic receptor alpha-1A (ADRA1A) DM64THP MT DTT DM64THP MA Inhibitor DM64THP RN Medetomidine analogs as alpha 2-adrenergic ligands. 2. Design, synthesis, and biological activity of conformationally restricted naphthalene deriva... J Med Chem. 1996 Jul 19;39(15):3001-13. DM64THP RU https://pubmed.ncbi.nlm.nih.gov/8709134 DM64THP DI DM64THP DM64THP DN 4-(1-Naphthalen-1-yl-propyl)-1H-imidazole DM64THP MI TTBRKXS DM64THP MN Adrenergic receptor alpha-1B (ADRA1B) DM64THP MT DTT DM64THP MA Inhibitor DM64THP RN Medetomidine analogs as alpha 2-adrenergic ligands. 2. Design, synthesis, and biological activity of conformationally restricted naphthalene deriva... J Med Chem. 1996 Jul 19;39(15):3001-13. DM64THP RU https://pubmed.ncbi.nlm.nih.gov/8709134 DM64THP DI DM64THP DM64THP DN 4-(1-Naphthalen-1-yl-propyl)-1H-imidazole DM64THP MI TT34BHT DM64THP MN Adrenergic receptor alpha-1D (ADRA1D) DM64THP MT DTT DM64THP MA Inhibitor DM64THP RN Medetomidine analogs as alpha 2-adrenergic ligands. 2. Design, synthesis, and biological activity of conformationally restricted naphthalene deriva... J Med Chem. 1996 Jul 19;39(15):3001-13. DM64THP RU https://pubmed.ncbi.nlm.nih.gov/8709134 DM49PR1 DI DM49PR1 DM49PR1 DN 4-(1-Naphthalen-1-yl-vinyl)-1H-imidazole DM49PR1 MI TTNGILX DM49PR1 MN Adrenergic receptor alpha-1A (ADRA1A) DM49PR1 MT DTT DM49PR1 MA Inhibitor DM49PR1 RN Medetomidine analogs as alpha 2-adrenergic ligands. 2. Design, synthesis, and biological activity of conformationally restricted naphthalene deriva... J Med Chem. 1996 Jul 19;39(15):3001-13. DM49PR1 RU https://pubmed.ncbi.nlm.nih.gov/8709134 DM49PR1 DI DM49PR1 DM49PR1 DN 4-(1-Naphthalen-1-yl-vinyl)-1H-imidazole DM49PR1 MI TTBRKXS DM49PR1 MN Adrenergic receptor alpha-1B (ADRA1B) DM49PR1 MT DTT DM49PR1 MA Inhibitor DM49PR1 RN Medetomidine analogs as alpha 2-adrenergic ligands. 2. Design, synthesis, and biological activity of conformationally restricted naphthalene deriva... J Med Chem. 1996 Jul 19;39(15):3001-13. DM49PR1 RU https://pubmed.ncbi.nlm.nih.gov/8709134 DM49PR1 DI DM49PR1 DM49PR1 DN 4-(1-Naphthalen-1-yl-vinyl)-1H-imidazole DM49PR1 MI TT34BHT DM49PR1 MN Adrenergic receptor alpha-1D (ADRA1D) DM49PR1 MT DTT DM49PR1 MA Inhibitor DM49PR1 RN Medetomidine analogs as alpha 2-adrenergic ligands. 2. Design, synthesis, and biological activity of conformationally restricted naphthalene deriva... J Med Chem. 1996 Jul 19;39(15):3001-13. DM49PR1 RU https://pubmed.ncbi.nlm.nih.gov/8709134 DMJ9CNA DI DMJ9CNA DMJ9CNA DN 4-(2-((3-fluorophenoxy)methyl)phenyl)piperidine DMJ9CNA MI TTVBI8W DMJ9CNA MN Dopamine transporter (DAT) DMJ9CNA MT DTT DMJ9CNA MA Inhibitor DMJ9CNA RN Discovery and pharmacological characterization of aryl piperazine and piperidine ethers as dual acting norepinephrine reuptake inhibitors and 5-HT1... Bioorg Med Chem Lett. 2009 Dec 1;19(23):6604-7. DMJ9CNA RU https://pubmed.ncbi.nlm.nih.gov/19854053 DMJ9CNA DI DMJ9CNA DMJ9CNA DN 4-(2-((3-fluorophenoxy)methyl)phenyl)piperidine DMJ9CNA MI TTAWNKZ DMJ9CNA MN Norepinephrine transporter (NET) DMJ9CNA MT DTT DMJ9CNA MA Inhibitor DMJ9CNA RN Discovery and pharmacological characterization of aryl piperazine and piperidine ethers as dual acting norepinephrine reuptake inhibitors and 5-HT1... Bioorg Med Chem Lett. 2009 Dec 1;19(23):6604-7. DMJ9CNA RU https://pubmed.ncbi.nlm.nih.gov/19854053 DMJ9CNA DI DMJ9CNA DMJ9CNA DN 4-(2-((3-fluorophenoxy)methyl)phenyl)piperidine DMJ9CNA MI TT3ROYC DMJ9CNA MN Serotonin transporter (SERT) DMJ9CNA MT DTT DMJ9CNA MA Inhibitor DMJ9CNA RN Discovery and pharmacological characterization of aryl piperazine and piperidine ethers as dual acting norepinephrine reuptake inhibitors and 5-HT1... Bioorg Med Chem Lett. 2009 Dec 1;19(23):6604-7. DMJ9CNA RU https://pubmed.ncbi.nlm.nih.gov/19854053 DM0MWVU DI DM0MWVU DM0MWVU DN 4-(2-((dimethylamino)methyl)phenoxy)benzonitrile DM0MWVU MI TT3ROYC DM0MWVU MN Serotonin transporter (SERT) DM0MWVU MT DTT DM0MWVU MA Inhibitor DM0MWVU RN Designing rapid onset selective serotonin re-uptake inhibitors. 2: structure-activity relationships of substituted (aryl)benzylamines. Bioorg Med Chem Lett. 2008 Jul 15;18(14):4018-21. DM0MWVU RU https://pubmed.ncbi.nlm.nih.gov/18571404 DM1043B DI DM1043B DM1043B DN 4-(2-(1H-imidazol-1-yl)ethoxy)-2H-chromen-2-one DM1043B MI TTSZLWK DM1043B MN Aromatase (CYP19A1) DM1043B MT DTT DM1043B MA Inhibitor DM1043B RN Fast three dimensional pharmacophore virtual screening of new potent non-steroid aromatase inhibitors. J Med Chem. 2009 Jan 8;52(1):143-50. DM1043B RU https://pubmed.ncbi.nlm.nih.gov/19072235 DMTJGBL DI DMTJGBL DMTJGBL DN 4-(2-(1H-indol-6-yl)-9H-purin-6-yl)morpholine DMTJGBL MI TTCJG29 DMTJGBL MN Serine/threonine-protein kinase mTOR (mTOR) DMTJGBL MT DTT DMTJGBL MA Inhibitor DMTJGBL RN Novel purine and pyrazolo[3,4-d]pyrimidine inhibitors of PI3 kinase-alpha: Hit to lead studies. Bioorg Med Chem Lett. 2010 Jan 15;20(2):636-9. DMTJGBL RU https://pubmed.ncbi.nlm.nih.gov/19969455 DM9UA0N DI DM9UA0N DM9UA0N DN 4-(2-(2-fluoro-5-methylphenoxy)phenyl)piperidine DM9UA0N MI TTSQIFT DM9UA0N MN 5-HT 1A receptor (HTR1A) DM9UA0N MT DTT DM9UA0N MA Inhibitor DM9UA0N RN Discovery and pharmacological characterization of aryl piperazine and piperidine ethers as dual acting norepinephrine reuptake inhibitors and 5-HT1... Bioorg Med Chem Lett. 2009 Dec 1;19(23):6604-7. DM9UA0N RU https://pubmed.ncbi.nlm.nih.gov/19854053 DM9UA0N DI DM9UA0N DM9UA0N DN 4-(2-(2-fluoro-5-methylphenoxy)phenyl)piperidine DM9UA0N MI TTVBI8W DM9UA0N MN Dopamine transporter (DAT) DM9UA0N MT DTT DM9UA0N MA Inhibitor DM9UA0N RN Discovery and pharmacological characterization of aryl piperazine and piperidine ethers as dual acting norepinephrine reuptake inhibitors and 5-HT1... Bioorg Med Chem Lett. 2009 Dec 1;19(23):6604-7. DM9UA0N RU https://pubmed.ncbi.nlm.nih.gov/19854053 DM9UA0N DI DM9UA0N DM9UA0N DN 4-(2-(2-fluoro-5-methylphenoxy)phenyl)piperidine DM9UA0N MI TTAWNKZ DM9UA0N MN Norepinephrine transporter (NET) DM9UA0N MT DTT DM9UA0N MA Inhibitor DM9UA0N RN Discovery and pharmacological characterization of aryl piperazine and piperidine ethers as dual acting norepinephrine reuptake inhibitors and 5-HT1... Bioorg Med Chem Lett. 2009 Dec 1;19(23):6604-7. DM9UA0N RU https://pubmed.ncbi.nlm.nih.gov/19854053 DM9UA0N DI DM9UA0N DM9UA0N DN 4-(2-(2-fluoro-5-methylphenoxy)phenyl)piperidine DM9UA0N MI TT3ROYC DM9UA0N MN Serotonin transporter (SERT) DM9UA0N MT DTT DM9UA0N MA Inhibitor DM9UA0N RN Discovery and pharmacological characterization of aryl piperazine and piperidine ethers as dual acting norepinephrine reuptake inhibitors and 5-HT1... Bioorg Med Chem Lett. 2009 Dec 1;19(23):6604-7. DM9UA0N RU https://pubmed.ncbi.nlm.nih.gov/19854053 DMCR3VM DI DMCR3VM DMCR3VM DN 4-(2-(2-fluorobenzyloxy)phenyl)piperidine DMCR3VM MI TTSQIFT DMCR3VM MN 5-HT 1A receptor (HTR1A) DMCR3VM MT DTT DMCR3VM MA Inhibitor DMCR3VM RN Discovery and pharmacological characterization of aryl piperazine and piperidine ethers as dual acting norepinephrine reuptake inhibitors and 5-HT1... Bioorg Med Chem Lett. 2009 Dec 1;19(23):6604-7. DMCR3VM RU https://pubmed.ncbi.nlm.nih.gov/19854053 DMCR3VM DI DMCR3VM DMCR3VM DN 4-(2-(2-fluorobenzyloxy)phenyl)piperidine DMCR3VM MI TTVBI8W DMCR3VM MN Dopamine transporter (DAT) DMCR3VM MT DTT DMCR3VM MA Inhibitor DMCR3VM RN Discovery and pharmacological characterization of aryl piperazine and piperidine ethers as dual acting norepinephrine reuptake inhibitors and 5-HT1... Bioorg Med Chem Lett. 2009 Dec 1;19(23):6604-7. DMCR3VM RU https://pubmed.ncbi.nlm.nih.gov/19854053 DMCR3VM DI DMCR3VM DMCR3VM DN 4-(2-(2-fluorobenzyloxy)phenyl)piperidine DMCR3VM MI TTAWNKZ DMCR3VM MN Norepinephrine transporter (NET) DMCR3VM MT DTT DMCR3VM MA Inhibitor DMCR3VM RN Discovery and pharmacological characterization of aryl piperazine and piperidine ethers as dual acting norepinephrine reuptake inhibitors and 5-HT1... Bioorg Med Chem Lett. 2009 Dec 1;19(23):6604-7. DMCR3VM RU https://pubmed.ncbi.nlm.nih.gov/19854053 DMCR3VM DI DMCR3VM DMCR3VM DN 4-(2-(2-fluorobenzyloxy)phenyl)piperidine DMCR3VM MI TT3ROYC DMCR3VM MN Serotonin transporter (SERT) DMCR3VM MT DTT DMCR3VM MA Inhibitor DMCR3VM RN Discovery and pharmacological characterization of aryl piperazine and piperidine ethers as dual acting norepinephrine reuptake inhibitors and 5-HT1... Bioorg Med Chem Lett. 2009 Dec 1;19(23):6604-7. DMCR3VM RU https://pubmed.ncbi.nlm.nih.gov/19854053 DMKZ6JW DI DMKZ6JW DMKZ6JW DN 4-(2-(3,4-Dimethylphenylamino)ethyl)-1H-imidazole DMKZ6JW MI TT9JNIC DMKZ6JW MN Histamine H3 receptor (H3R) DMKZ6JW MT DTT DMKZ6JW MA Inhibitor DMKZ6JW RN Role of hydrophobic substituents on the terminal nitrogen of histamine in receptor binding and agonist activity: development of an orally active hi... J Med Chem. 2010 May 13;53(9):3840-4. DMKZ6JW RU https://pubmed.ncbi.nlm.nih.gov/20384344 DM0IT5E DI DM0IT5E DM0IT5E DN 4-(2-(3-chlorophenoxy)phenyl)piperidine DM0IT5E MI TTSQIFT DM0IT5E MN 5-HT 1A receptor (HTR1A) DM0IT5E MT DTT DM0IT5E MA Inhibitor DM0IT5E RN Discovery and pharmacological characterization of aryl piperazine and piperidine ethers as dual acting norepinephrine reuptake inhibitors and 5-HT1... Bioorg Med Chem Lett. 2009 Dec 1;19(23):6604-7. DM0IT5E RU https://pubmed.ncbi.nlm.nih.gov/19854053 DM0IT5E DI DM0IT5E DM0IT5E DN 4-(2-(3-chlorophenoxy)phenyl)piperidine DM0IT5E MI TTVBI8W DM0IT5E MN Dopamine transporter (DAT) DM0IT5E MT DTT DM0IT5E MA Inhibitor DM0IT5E RN Discovery and pharmacological characterization of aryl piperazine and piperidine ethers as dual acting norepinephrine reuptake inhibitors and 5-HT1... Bioorg Med Chem Lett. 2009 Dec 1;19(23):6604-7. DM0IT5E RU https://pubmed.ncbi.nlm.nih.gov/19854053 DM0IT5E DI DM0IT5E DM0IT5E DN 4-(2-(3-chlorophenoxy)phenyl)piperidine DM0IT5E MI TTAWNKZ DM0IT5E MN Norepinephrine transporter (NET) DM0IT5E MT DTT DM0IT5E MA Inhibitor DM0IT5E RN Discovery and pharmacological characterization of aryl piperazine and piperidine ethers as dual acting norepinephrine reuptake inhibitors and 5-HT1... Bioorg Med Chem Lett. 2009 Dec 1;19(23):6604-7. DM0IT5E RU https://pubmed.ncbi.nlm.nih.gov/19854053 DM0IT5E DI DM0IT5E DM0IT5E DN 4-(2-(3-chlorophenoxy)phenyl)piperidine DM0IT5E MI TT3ROYC DM0IT5E MN Serotonin transporter (SERT) DM0IT5E MT DTT DM0IT5E MA Inhibitor DM0IT5E RN Discovery and pharmacological characterization of aryl piperazine and piperidine ethers as dual acting norepinephrine reuptake inhibitors and 5-HT1... Bioorg Med Chem Lett. 2009 Dec 1;19(23):6604-7. DM0IT5E RU https://pubmed.ncbi.nlm.nih.gov/19854053 DMEPB9L DI DMEPB9L DMEPB9L DN 4-(2-(3-fluorophenoxy)-4-methylphenyl)piperidine DMEPB9L MI TTVBI8W DMEPB9L MN Dopamine transporter (DAT) DMEPB9L MT DTT DMEPB9L MA Inhibitor DMEPB9L RN Discovery and pharmacological characterization of aryl piperazine and piperidine ethers as dual acting norepinephrine reuptake inhibitors and 5-HT1... Bioorg Med Chem Lett. 2009 Dec 1;19(23):6604-7. DMEPB9L RU https://pubmed.ncbi.nlm.nih.gov/19854053 DMEPB9L DI DMEPB9L DMEPB9L DN 4-(2-(3-fluorophenoxy)-4-methylphenyl)piperidine DMEPB9L MI TTAWNKZ DMEPB9L MN Norepinephrine transporter (NET) DMEPB9L MT DTT DMEPB9L MA Inhibitor DMEPB9L RN Discovery and pharmacological characterization of aryl piperazine and piperidine ethers as dual acting norepinephrine reuptake inhibitors and 5-HT1... Bioorg Med Chem Lett. 2009 Dec 1;19(23):6604-7. DMEPB9L RU https://pubmed.ncbi.nlm.nih.gov/19854053 DMEPB9L DI DMEPB9L DMEPB9L DN 4-(2-(3-fluorophenoxy)-4-methylphenyl)piperidine DMEPB9L MI TT3ROYC DMEPB9L MN Serotonin transporter (SERT) DMEPB9L MT DTT DMEPB9L MA Inhibitor DMEPB9L RN Discovery and pharmacological characterization of aryl piperazine and piperidine ethers as dual acting norepinephrine reuptake inhibitors and 5-HT1... Bioorg Med Chem Lett. 2009 Dec 1;19(23):6604-7. DMEPB9L RU https://pubmed.ncbi.nlm.nih.gov/19854053 DMZMEOG DI DMZMEOG DMZMEOG DN 4-(2-(3-fluorophenoxy)phenyl)piperidine DMZMEOG MI TTSQIFT DMZMEOG MN 5-HT 1A receptor (HTR1A) DMZMEOG MT DTT DMZMEOG MA Inhibitor DMZMEOG RN Discovery and pharmacological characterization of aryl piperazine and piperidine ethers as dual acting norepinephrine reuptake inhibitors and 5-HT1... Bioorg Med Chem Lett. 2009 Dec 1;19(23):6604-7. DMZMEOG RU https://pubmed.ncbi.nlm.nih.gov/19854053 DMZMEOG DI DMZMEOG DMZMEOG DN 4-(2-(3-fluorophenoxy)phenyl)piperidine DMZMEOG MI TTVBI8W DMZMEOG MN Dopamine transporter (DAT) DMZMEOG MT DTT DMZMEOG MA Inhibitor DMZMEOG RN Discovery and pharmacological characterization of aryl piperazine and piperidine ethers as dual acting norepinephrine reuptake inhibitors and 5-HT1... Bioorg Med Chem Lett. 2009 Dec 1;19(23):6604-7. DMZMEOG RU https://pubmed.ncbi.nlm.nih.gov/19854053 DMZMEOG DI DMZMEOG DMZMEOG DN 4-(2-(3-fluorophenoxy)phenyl)piperidine DMZMEOG MI TTAWNKZ DMZMEOG MN Norepinephrine transporter (NET) DMZMEOG MT DTT DMZMEOG MA Inhibitor DMZMEOG RN Discovery and pharmacological characterization of aryl piperazine and piperidine ethers as dual acting norepinephrine reuptake inhibitors and 5-HT1... Bioorg Med Chem Lett. 2009 Dec 1;19(23):6604-7. DMZMEOG RU https://pubmed.ncbi.nlm.nih.gov/19854053 DMZMEOG DI DMZMEOG DMZMEOG DN 4-(2-(3-fluorophenoxy)phenyl)piperidine DMZMEOG MI TT3ROYC DMZMEOG MN Serotonin transporter (SERT) DMZMEOG MT DTT DMZMEOG MA Inhibitor DMZMEOG RN Discovery and pharmacological characterization of aryl piperazine and piperidine ethers as dual acting norepinephrine reuptake inhibitors and 5-HT1... Bioorg Med Chem Lett. 2009 Dec 1;19(23):6604-7. DMZMEOG RU https://pubmed.ncbi.nlm.nih.gov/19854053 DMRDWUT DI DMRDWUT DMRDWUT DN 4-(2-(3-fluorophenyl)ethynyl)-2-methylthiazole DMRDWUT MI TTHS256 DMRDWUT MN Metabotropic glutamate receptor 5 (mGluR5) DMRDWUT MT DTT DMRDWUT MA Inhibitor DMRDWUT RN Synthesis and structure-activity relationships of 3-[(2-methyl-1,3-thiazol-4-yl)ethynyl]pyridine analogues as potent, noncompetitive metabotropic g... J Med Chem. 2006 Feb 9;49(3):1080-100. DMRDWUT RU https://pubmed.ncbi.nlm.nih.gov/16451073 DMP1LY4 DI DMP1LY4 DMP1LY4 DN 4-(2-(3-tert-Butylphenylamino)ethyl)-1H-imidazole DMP1LY4 MI TT9JNIC DMP1LY4 MN Histamine H3 receptor (H3R) DMP1LY4 MT DTT DMP1LY4 MA Inhibitor DMP1LY4 RN Role of hydrophobic substituents on the terminal nitrogen of histamine in receptor binding and agonist activity: development of an orally active hi... J Med Chem. 2010 May 13;53(9):3840-4. DMP1LY4 RU https://pubmed.ncbi.nlm.nih.gov/20384344 DMN97TC DI DMN97TC DMN97TC DN 4-(2-(4-chlorobenzyloxy)-5-bromobenzyl)morpholine DMN97TC MI TT2CEJG DMN97TC MN C-C chemokine receptor type 5 (CCR5) DMN97TC MT DTT DMN97TC MA Inhibitor DMN97TC RN CCR5 receptor antagonists: discovery and SAR study of guanylhydrazone derivatives. Bioorg Med Chem Lett. 2007 Jan 1;17(1):231-4. DMN97TC RU https://pubmed.ncbi.nlm.nih.gov/17081751 DMM8CU2 DI DMM8CU2 DMM8CU2 DN 4-(2-(4-Cyclohexylphenylamino)ethyl)-1H-imidazole DMM8CU2 MI TT9JNIC DMM8CU2 MN Histamine H3 receptor (H3R) DMM8CU2 MT DTT DMM8CU2 MA Inhibitor DMM8CU2 RN Role of hydrophobic substituents on the terminal nitrogen of histamine in receptor binding and agonist activity: development of an orally active hi... J Med Chem. 2010 May 13;53(9):3840-4. DMM8CU2 RU https://pubmed.ncbi.nlm.nih.gov/20384344 DM29QLG DI DM29QLG DM29QLG DN 4-(2-(4-fluorobenzyloxy)phenyl)piperidine DM29QLG MI TTSQIFT DM29QLG MN 5-HT 1A receptor (HTR1A) DM29QLG MT DTT DM29QLG MA Inhibitor DM29QLG RN Discovery and pharmacological characterization of aryl piperazine and piperidine ethers as dual acting norepinephrine reuptake inhibitors and 5-HT1... Bioorg Med Chem Lett. 2009 Dec 1;19(23):6604-7. DM29QLG RU https://pubmed.ncbi.nlm.nih.gov/19854053 DM29QLG DI DM29QLG DM29QLG DN 4-(2-(4-fluorobenzyloxy)phenyl)piperidine DM29QLG MI TTVBI8W DM29QLG MN Dopamine transporter (DAT) DM29QLG MT DTT DM29QLG MA Inhibitor DM29QLG RN Discovery and pharmacological characterization of aryl piperazine and piperidine ethers as dual acting norepinephrine reuptake inhibitors and 5-HT1... Bioorg Med Chem Lett. 2009 Dec 1;19(23):6604-7. DM29QLG RU https://pubmed.ncbi.nlm.nih.gov/19854053 DM29QLG DI DM29QLG DM29QLG DN 4-(2-(4-fluorobenzyloxy)phenyl)piperidine DM29QLG MI TTAWNKZ DM29QLG MN Norepinephrine transporter (NET) DM29QLG MT DTT DM29QLG MA Inhibitor DM29QLG RN Discovery and pharmacological characterization of aryl piperazine and piperidine ethers as dual acting norepinephrine reuptake inhibitors and 5-HT1... Bioorg Med Chem Lett. 2009 Dec 1;19(23):6604-7. DM29QLG RU https://pubmed.ncbi.nlm.nih.gov/19854053 DM29QLG DI DM29QLG DM29QLG DN 4-(2-(4-fluorobenzyloxy)phenyl)piperidine DM29QLG MI TT3ROYC DM29QLG MN Serotonin transporter (SERT) DM29QLG MT DTT DM29QLG MA Inhibitor DM29QLG RN Discovery and pharmacological characterization of aryl piperazine and piperidine ethers as dual acting norepinephrine reuptake inhibitors and 5-HT1... Bioorg Med Chem Lett. 2009 Dec 1;19(23):6604-7. DM29QLG RU https://pubmed.ncbi.nlm.nih.gov/19854053 DMJNB8C DI DMJNB8C DMJNB8C DN 4-(2-(4-fluorophenoxy)-4-methylphenyl)piperidine DMJNB8C MI TTVBI8W DMJNB8C MN Dopamine transporter (DAT) DMJNB8C MT DTT DMJNB8C MA Inhibitor DMJNB8C RN Discovery and pharmacological characterization of aryl piperazine and piperidine ethers as dual acting norepinephrine reuptake inhibitors and 5-HT1... Bioorg Med Chem Lett. 2009 Dec 1;19(23):6604-7. DMJNB8C RU https://pubmed.ncbi.nlm.nih.gov/19854053 DMJNB8C DI DMJNB8C DMJNB8C DN 4-(2-(4-fluorophenoxy)-4-methylphenyl)piperidine DMJNB8C MI TTAWNKZ DMJNB8C MN Norepinephrine transporter (NET) DMJNB8C MT DTT DMJNB8C MA Inhibitor DMJNB8C RN Discovery and pharmacological characterization of aryl piperazine and piperidine ethers as dual acting norepinephrine reuptake inhibitors and 5-HT1... Bioorg Med Chem Lett. 2009 Dec 1;19(23):6604-7. DMJNB8C RU https://pubmed.ncbi.nlm.nih.gov/19854053 DMJNB8C DI DMJNB8C DMJNB8C DN 4-(2-(4-fluorophenoxy)-4-methylphenyl)piperidine DMJNB8C MI TT3ROYC DMJNB8C MN Serotonin transporter (SERT) DMJNB8C MT DTT DMJNB8C MA Inhibitor DMJNB8C RN Discovery and pharmacological characterization of aryl piperazine and piperidine ethers as dual acting norepinephrine reuptake inhibitors and 5-HT1... Bioorg Med Chem Lett. 2009 Dec 1;19(23):6604-7. DMJNB8C RU https://pubmed.ncbi.nlm.nih.gov/19854053 DMFQT9O DI DMFQT9O DMFQT9O DN 4-(2-(4-fluorophenoxy)phenyl)piperidine DMFQT9O MI TTSQIFT DMFQT9O MN 5-HT 1A receptor (HTR1A) DMFQT9O MT DTT DMFQT9O MA Inhibitor DMFQT9O RN Discovery and pharmacological characterization of aryl piperazine and piperidine ethers as dual acting norepinephrine reuptake inhibitors and 5-HT1... Bioorg Med Chem Lett. 2009 Dec 1;19(23):6604-7. DMFQT9O RU https://pubmed.ncbi.nlm.nih.gov/19854053 DMFQT9O DI DMFQT9O DMFQT9O DN 4-(2-(4-fluorophenoxy)phenyl)piperidine DMFQT9O MI TTVBI8W DMFQT9O MN Dopamine transporter (DAT) DMFQT9O MT DTT DMFQT9O MA Inhibitor DMFQT9O RN Discovery and pharmacological characterization of aryl piperazine and piperidine ethers as dual acting norepinephrine reuptake inhibitors and 5-HT1... Bioorg Med Chem Lett. 2009 Dec 1;19(23):6604-7. DMFQT9O RU https://pubmed.ncbi.nlm.nih.gov/19854053 DMFQT9O DI DMFQT9O DMFQT9O DN 4-(2-(4-fluorophenoxy)phenyl)piperidine DMFQT9O MI TTAWNKZ DMFQT9O MN Norepinephrine transporter (NET) DMFQT9O MT DTT DMFQT9O MA Inhibitor DMFQT9O RN Discovery and pharmacological characterization of aryl piperazine and piperidine ethers as dual acting norepinephrine reuptake inhibitors and 5-HT1... Bioorg Med Chem Lett. 2009 Dec 1;19(23):6604-7. DMFQT9O RU https://pubmed.ncbi.nlm.nih.gov/19854053 DMFQT9O DI DMFQT9O DMFQT9O DN 4-(2-(4-fluorophenoxy)phenyl)piperidine DMFQT9O MI TT3ROYC DMFQT9O MN Serotonin transporter (SERT) DMFQT9O MT DTT DMFQT9O MA Inhibitor DMFQT9O RN Discovery and pharmacological characterization of aryl piperazine and piperidine ethers as dual acting norepinephrine reuptake inhibitors and 5-HT1... Bioorg Med Chem Lett. 2009 Dec 1;19(23):6604-7. DMFQT9O RU https://pubmed.ncbi.nlm.nih.gov/19854053 DMOX40J DI DMOX40J DMOX40J DN 4-(2-(4-fluorophenyl)ethynyl)-2-methylthiazole DMOX40J MI TTHS256 DMOX40J MN Metabotropic glutamate receptor 5 (mGluR5) DMOX40J MT DTT DMOX40J MA Inhibitor DMOX40J RN Synthesis and structure-activity relationships of 3-[(2-methyl-1,3-thiazol-4-yl)ethynyl]pyridine analogues as potent, noncompetitive metabotropic g... J Med Chem. 2006 Feb 9;49(3):1080-100. DMOX40J RU https://pubmed.ncbi.nlm.nih.gov/16451073 DMFCS8G DI DMFCS8G DMFCS8G DN 4-(2-(4-Methoxyphenylamino)ethyl)-1H-imidazole DMFCS8G MI TT9JNIC DMFCS8G MN Histamine H3 receptor (H3R) DMFCS8G MT DTT DMFCS8G MA Inhibitor DMFCS8G RN Role of hydrophobic substituents on the terminal nitrogen of histamine in receptor binding and agonist activity: development of an orally active hi... J Med Chem. 2010 May 13;53(9):3840-4. DMFCS8G RU https://pubmed.ncbi.nlm.nih.gov/20384344 DMYM72T DI DMYM72T DMYM72T DN 4-(2-(4-Methylphenylamino)ethyl)-1H-imidazole DMYM72T MI TT9JNIC DMYM72T MN Histamine H3 receptor (H3R) DMYM72T MT DTT DMYM72T MA Inhibitor DMYM72T RN Role of hydrophobic substituents on the terminal nitrogen of histamine in receptor binding and agonist activity: development of an orally active hi... J Med Chem. 2010 May 13;53(9):3840-4. DMYM72T RU https://pubmed.ncbi.nlm.nih.gov/20384344 DMK8ROX DI DMK8ROX DMK8ROX DN 4-(2-(4-tert-Butylphenylamino)ethyl)-1H-imidazole DMK8ROX MI TT9JNIC DMK8ROX MN Histamine H3 receptor (H3R) DMK8ROX MT DTT DMK8ROX MA Inhibitor DMK8ROX RN Role of hydrophobic substituents on the terminal nitrogen of histamine in receptor binding and agonist activity: development of an orally active hi... J Med Chem. 2010 May 13;53(9):3840-4. DMK8ROX RU https://pubmed.ncbi.nlm.nih.gov/20384344 DMUYPMO DI DMUYPMO DMUYPMO DN 4-(2-(aminomethyl)phenyl)-1-benzylpiperidin-4-ol DMUYPMO MI TTNT7K8 DMUYPMO MN Nociceptin receptor (OPRL1) DMUYPMO MT DTT DMUYPMO MA Inhibitor DMUYPMO RN Bioorg Med Chem Lett. 2007 Jun 1;17(11):3028-33. Epub 2007 Mar 21.Synthesis and structure-activity relationships of 4-hydroxy-4-phenylpiperidines as nociceptin receptor ligands: Part 2. DMUYPMO RU https://pubmed.ncbi.nlm.nih.gov/17420123 DMM2NHZ DI DMM2NHZ DMM2NHZ DN 4-(2-(benzyloxy)-3-fluorophenyl)piperidine DMM2NHZ MI TTSQIFT DMM2NHZ MN 5-HT 1A receptor (HTR1A) DMM2NHZ MT DTT DMM2NHZ MA Inhibitor DMM2NHZ RN Discovery and pharmacological characterization of aryl piperazine and piperidine ethers as dual acting norepinephrine reuptake inhibitors and 5-HT1... Bioorg Med Chem Lett. 2009 Dec 1;19(23):6604-7. DMM2NHZ RU https://pubmed.ncbi.nlm.nih.gov/19854053 DMM2NHZ DI DMM2NHZ DMM2NHZ DN 4-(2-(benzyloxy)-3-fluorophenyl)piperidine DMM2NHZ MI TTVBI8W DMM2NHZ MN Dopamine transporter (DAT) DMM2NHZ MT DTT DMM2NHZ MA Inhibitor DMM2NHZ RN Discovery and pharmacological characterization of aryl piperazine and piperidine ethers as dual acting norepinephrine reuptake inhibitors and 5-HT1... Bioorg Med Chem Lett. 2009 Dec 1;19(23):6604-7. DMM2NHZ RU https://pubmed.ncbi.nlm.nih.gov/19854053 DMM2NHZ DI DMM2NHZ DMM2NHZ DN 4-(2-(benzyloxy)-3-fluorophenyl)piperidine DMM2NHZ MI TTAWNKZ DMM2NHZ MN Norepinephrine transporter (NET) DMM2NHZ MT DTT DMM2NHZ MA Inhibitor DMM2NHZ RN Discovery and pharmacological characterization of aryl piperazine and piperidine ethers as dual acting norepinephrine reuptake inhibitors and 5-HT1... Bioorg Med Chem Lett. 2009 Dec 1;19(23):6604-7. DMM2NHZ RU https://pubmed.ncbi.nlm.nih.gov/19854053 DMM2NHZ DI DMM2NHZ DMM2NHZ DN 4-(2-(benzyloxy)-3-fluorophenyl)piperidine DMM2NHZ MI TT3ROYC DMM2NHZ MN Serotonin transporter (SERT) DMM2NHZ MT DTT DMM2NHZ MA Inhibitor DMM2NHZ RN Discovery and pharmacological characterization of aryl piperazine and piperidine ethers as dual acting norepinephrine reuptake inhibitors and 5-HT1... Bioorg Med Chem Lett. 2009 Dec 1;19(23):6604-7. DMM2NHZ RU https://pubmed.ncbi.nlm.nih.gov/19854053 DMF3S50 DI DMF3S50 DMF3S50 DN 4-(2-(benzyloxy)-6-fluorophenyl)piperidine DMF3S50 MI TTSQIFT DMF3S50 MN 5-HT 1A receptor (HTR1A) DMF3S50 MT DTT DMF3S50 MA Inhibitor DMF3S50 RN Discovery and pharmacological characterization of aryl piperazine and piperidine ethers as dual acting norepinephrine reuptake inhibitors and 5-HT1... Bioorg Med Chem Lett. 2009 Dec 1;19(23):6604-7. DMF3S50 RU https://pubmed.ncbi.nlm.nih.gov/19854053 DMF3S50 DI DMF3S50 DMF3S50 DN 4-(2-(benzyloxy)-6-fluorophenyl)piperidine DMF3S50 MI TTVBI8W DMF3S50 MN Dopamine transporter (DAT) DMF3S50 MT DTT DMF3S50 MA Inhibitor DMF3S50 RN Discovery and pharmacological characterization of aryl piperazine and piperidine ethers as dual acting norepinephrine reuptake inhibitors and 5-HT1... Bioorg Med Chem Lett. 2009 Dec 1;19(23):6604-7. DMF3S50 RU https://pubmed.ncbi.nlm.nih.gov/19854053 DMF3S50 DI DMF3S50 DMF3S50 DN 4-(2-(benzyloxy)-6-fluorophenyl)piperidine DMF3S50 MI TTAWNKZ DMF3S50 MN Norepinephrine transporter (NET) DMF3S50 MT DTT DMF3S50 MA Inhibitor DMF3S50 RN Discovery and pharmacological characterization of aryl piperazine and piperidine ethers as dual acting norepinephrine reuptake inhibitors and 5-HT1... Bioorg Med Chem Lett. 2009 Dec 1;19(23):6604-7. DMF3S50 RU https://pubmed.ncbi.nlm.nih.gov/19854053 DMF3S50 DI DMF3S50 DMF3S50 DN 4-(2-(benzyloxy)-6-fluorophenyl)piperidine DMF3S50 MI TT3ROYC DMF3S50 MN Serotonin transporter (SERT) DMF3S50 MT DTT DMF3S50 MA Inhibitor DMF3S50 RN Discovery and pharmacological characterization of aryl piperazine and piperidine ethers as dual acting norepinephrine reuptake inhibitors and 5-HT1... Bioorg Med Chem Lett. 2009 Dec 1;19(23):6604-7. DMF3S50 RU https://pubmed.ncbi.nlm.nih.gov/19854053 DMOC7PY DI DMOC7PY DMOC7PY DN 4-(2-(benzyloxy)phenyl)piperidine DMOC7PY MI TTSQIFT DMOC7PY MN 5-HT 1A receptor (HTR1A) DMOC7PY MT DTT DMOC7PY MA Inhibitor DMOC7PY RN Discovery and pharmacological characterization of aryl piperazine and piperidine ethers as dual acting norepinephrine reuptake inhibitors and 5-HT1... Bioorg Med Chem Lett. 2009 Dec 1;19(23):6604-7. DMOC7PY RU https://pubmed.ncbi.nlm.nih.gov/19854053 DMOC7PY DI DMOC7PY DMOC7PY DN 4-(2-(benzyloxy)phenyl)piperidine DMOC7PY MI TTVBI8W DMOC7PY MN Dopamine transporter (DAT) DMOC7PY MT DTT DMOC7PY MA Inhibitor DMOC7PY RN Discovery and pharmacological characterization of aryl piperazine and piperidine ethers as dual acting norepinephrine reuptake inhibitors and 5-HT1... Bioorg Med Chem Lett. 2009 Dec 1;19(23):6604-7. DMOC7PY RU https://pubmed.ncbi.nlm.nih.gov/19854053 DMOC7PY DI DMOC7PY DMOC7PY DN 4-(2-(benzyloxy)phenyl)piperidine DMOC7PY MI TTAWNKZ DMOC7PY MN Norepinephrine transporter (NET) DMOC7PY MT DTT DMOC7PY MA Inhibitor DMOC7PY RN Discovery and pharmacological characterization of aryl piperazine and piperidine ethers as dual acting norepinephrine reuptake inhibitors and 5-HT1... Bioorg Med Chem Lett. 2009 Dec 1;19(23):6604-7. DMOC7PY RU https://pubmed.ncbi.nlm.nih.gov/19854053 DMOC7PY DI DMOC7PY DMOC7PY DN 4-(2-(benzyloxy)phenyl)piperidine DMOC7PY MI TT3ROYC DMOC7PY MN Serotonin transporter (SERT) DMOC7PY MT DTT DMOC7PY MA Inhibitor DMOC7PY RN Discovery and pharmacological characterization of aryl piperazine and piperidine ethers as dual acting norepinephrine reuptake inhibitors and 5-HT1... Bioorg Med Chem Lett. 2009 Dec 1;19(23):6604-7. DMOC7PY RU https://pubmed.ncbi.nlm.nih.gov/19854053 DM1MP96 DI DM1MP96 DM1MP96 DN 4-(2-(Cyclohexylamino)ethyl)-1H-imidazole DM1MP96 MI TT9JNIC DM1MP96 MN Histamine H3 receptor (H3R) DM1MP96 MT DTT DM1MP96 MA Inhibitor DM1MP96 RN Role of hydrophobic substituents on the terminal nitrogen of histamine in receptor binding and agonist activity: development of an orally active hi... J Med Chem. 2010 May 13;53(9):3840-4. DM1MP96 RU https://pubmed.ncbi.nlm.nih.gov/20384344 DMRQ8T9 DI DMRQ8T9 DMRQ8T9 DN 4-(2-(diethylamino)ethylamino)-1-naphthol DMRQ8T9 MI TTZJYKH DMRQ8T9 MN Indoleamine 2,3-dioxygenase 1 (IDO1) DMRQ8T9 MT DTT DMRQ8T9 MA Inhibitor DMRQ8T9 RN Rational design of indoleamine 2,3-dioxygenase inhibitors. J Med Chem. 2010 Feb 11;53(3):1172-89. DMRQ8T9 RU https://pubmed.ncbi.nlm.nih.gov/20055453 DM0OFRQ DI DM0OFRQ DM0OFRQ DN 4-(2-(phenoxymethyl)phenyl)piperidine DM0OFRQ MI TTVBI8W DM0OFRQ MN Dopamine transporter (DAT) DM0OFRQ MT DTT DM0OFRQ MA Inhibitor DM0OFRQ RN Discovery and pharmacological characterization of aryl piperazine and piperidine ethers as dual acting norepinephrine reuptake inhibitors and 5-HT1... Bioorg Med Chem Lett. 2009 Dec 1;19(23):6604-7. DM0OFRQ RU https://pubmed.ncbi.nlm.nih.gov/19854053 DM0OFRQ DI DM0OFRQ DM0OFRQ DN 4-(2-(phenoxymethyl)phenyl)piperidine DM0OFRQ MI TTAWNKZ DM0OFRQ MN Norepinephrine transporter (NET) DM0OFRQ MT DTT DM0OFRQ MA Inhibitor DM0OFRQ RN Discovery and pharmacological characterization of aryl piperazine and piperidine ethers as dual acting norepinephrine reuptake inhibitors and 5-HT1... Bioorg Med Chem Lett. 2009 Dec 1;19(23):6604-7. DM0OFRQ RU https://pubmed.ncbi.nlm.nih.gov/19854053 DM0OFRQ DI DM0OFRQ DM0OFRQ DN 4-(2-(phenoxymethyl)phenyl)piperidine DM0OFRQ MI TT3ROYC DM0OFRQ MN Serotonin transporter (SERT) DM0OFRQ MT DTT DM0OFRQ MA Inhibitor DM0OFRQ RN Discovery and pharmacological characterization of aryl piperazine and piperidine ethers as dual acting norepinephrine reuptake inhibitors and 5-HT1... Bioorg Med Chem Lett. 2009 Dec 1;19(23):6604-7. DM0OFRQ RU https://pubmed.ncbi.nlm.nih.gov/19854053 DMX1HKU DI DMX1HKU DMX1HKU DN 4-(2-(Phenylamino)ethyl)-1H-imidazole DMX1HKU MI TT9JNIC DMX1HKU MN Histamine H3 receptor (H3R) DMX1HKU MT DTT DMX1HKU MA Inhibitor DMX1HKU RN Role of hydrophobic substituents on the terminal nitrogen of histamine in receptor binding and agonist activity: development of an orally active hi... J Med Chem. 2010 May 13;53(9):3840-4. DMX1HKU RU https://pubmed.ncbi.nlm.nih.gov/20384344 DMHWD2C DI DMHWD2C DMHWD2C DN 4-(2-(pyrrolidin-1-yl)ethyl)pyridine DMHWD2C MI TT9JNIC DMHWD2C MN Histamine H3 receptor (H3R) DMHWD2C MT DTT DMHWD2C MA Inhibitor DMHWD2C RN In vitro SAR of pyrrolidine-containing histamine H3 receptor antagonists: trends across multiple chemical series. Bioorg Med Chem Lett. 2008 Jan 1;18(1):355-9. DMHWD2C RU https://pubmed.ncbi.nlm.nih.gov/18077160 DMWN1CM DI DMWN1CM DMWN1CM DN 4-(2-(thiophen-2-yl)-9H-purin-6-yl)morpholine DMWN1CM MI TTCJG29 DMWN1CM MN Serine/threonine-protein kinase mTOR (mTOR) DMWN1CM MT DTT DMWN1CM MA Inhibitor DMWN1CM RN Novel purine and pyrazolo[3,4-d]pyrimidine inhibitors of PI3 kinase-alpha: Hit to lead studies. Bioorg Med Chem Lett. 2010 Jan 15;20(2):636-9. DMWN1CM RU https://pubmed.ncbi.nlm.nih.gov/19969455 DMAO6X9 DI DMAO6X9 DMAO6X9 DN 4-(2-(thiophen-3-yl)-9H-purin-6-yl)morpholine DMAO6X9 MI TTCJG29 DMAO6X9 MN Serine/threonine-protein kinase mTOR (mTOR) DMAO6X9 MT DTT DMAO6X9 MA Inhibitor DMAO6X9 RN Novel purine and pyrazolo[3,4-d]pyrimidine inhibitors of PI3 kinase-alpha: Hit to lead studies. Bioorg Med Chem Lett. 2010 Jan 15;20(2):636-9. DMAO6X9 RU https://pubmed.ncbi.nlm.nih.gov/19969455 DMIL45X DI DMIL45X DMIL45X DN 4-(2'-(trifluoromethoxy)biphenyl-3-yl)oxazole DMIL45X MI TT4G2JS DMIL45X MN Voltage-gated sodium channel alpha Nav1.7 (SCN9A) DMIL45X MT DTT DMIL45X MA Inhibitor DMIL45X RN Substituted biaryl oxazoles, imidazoles, and thiazoles as sodium channel blockers. Bioorg Med Chem Lett. 2010 Sep 15;20(18):5536-40. DMIL45X RU https://pubmed.ncbi.nlm.nih.gov/20709552 DM3R2D1 DI DM3R2D1 DM3R2D1 DN 4-(2'-(trifluoromethoxy)biphenyl-3-yl)thiazole DM3R2D1 MI TT4G2JS DM3R2D1 MN Voltage-gated sodium channel alpha Nav1.7 (SCN9A) DM3R2D1 MT DTT DM3R2D1 MA Inhibitor DM3R2D1 RN Substituted biaryl oxazoles, imidazoles, and thiazoles as sodium channel blockers. Bioorg Med Chem Lett. 2010 Sep 15;20(18):5536-40. DM3R2D1 RU https://pubmed.ncbi.nlm.nih.gov/20709552 DMXC5S0 DI DMXC5S0 DMXC5S0 DN 4-(2'-(trifluoromethyl)biphenyl-3-yl)oxazole DMXC5S0 MI TT4G2JS DMXC5S0 MN Voltage-gated sodium channel alpha Nav1.7 (SCN9A) DMXC5S0 MT DTT DMXC5S0 MA Inhibitor DMXC5S0 RN Substituted biaryl oxazoles, imidazoles, and thiazoles as sodium channel blockers. Bioorg Med Chem Lett. 2010 Sep 15;20(18):5536-40. DMXC5S0 RU https://pubmed.ncbi.nlm.nih.gov/20709552 DMRZY0B DI DMRZY0B DMRZY0B DN 4-(2,2'-bithiophen-5-ylmethyleneamino)phenol DMRZY0B MI TTHY57M DMRZY0B MN Matrix metalloproteinase-13 (MMP-13) DMRZY0B MT DTT DMRZY0B MA Inhibitor DMRZY0B RN High throughput screening of potentially selective MMP-13 exosite inhibitors utilizing a triple-helical FRET substrate. Bioorg Med Chem. 2009 Feb 1;17(3):990-1005. DMRZY0B RU https://pubmed.ncbi.nlm.nih.gov/18358729 DMI638K DI DMI638K DMI638K DN 4-(2,2-Diphenyl-vinyl)-pyridine DMI638K MI TTSZLWK DMI638K MN Aromatase (CYP19A1) DMI638K MT DTT DMI638K MA Inhibitor DMI638K RN Synthesis and evaluation of (pyridylmethylene)tetrahydronaphthalenes/-indanes and structurally modified derivatives: potent and selective inhibitor... J Med Chem. 2005 Mar 10;48(5):1563-75. DMI638K RU https://pubmed.ncbi.nlm.nih.gov/15743198 DMGOHSF DI DMGOHSF DMGOHSF DN 4-(2,3-dichlorobenzylthio)-2-aminobutanoic acid DMGOHSF MI TTFK1JQ DMGOHSF MN Voltage-gated calcium channel alpha-2/delta-1 (CACNA2D1) DMGOHSF MT DTT DMGOHSF MA Inhibitor DMGOHSF RN Structure-activity relationships of alpha-amino acid ligands for the alpha2delta subunit of voltage-gated calcium channels. Bioorg Med Chem Lett. 2006 Mar 1;16(5):1138-41. DMGOHSF RU https://pubmed.ncbi.nlm.nih.gov/16380257 DMVIQ7F DI DMVIQ7F DMVIQ7F DN 4-(2,3-Dihydro-1H-phenalen-1-yl)-1H-imidazole DMVIQ7F MI TTNGILX DMVIQ7F MN Adrenergic receptor alpha-1A (ADRA1A) DMVIQ7F MT DTT DMVIQ7F MA Inhibitor DMVIQ7F RN Medetomidine analogs as alpha 2-adrenergic ligands. 2. Design, synthesis, and biological activity of conformationally restricted naphthalene deriva... J Med Chem. 1996 Jul 19;39(15):3001-13. DMVIQ7F RU https://pubmed.ncbi.nlm.nih.gov/8709134 DMVIQ7F DI DMVIQ7F DMVIQ7F DN 4-(2,3-Dihydro-1H-phenalen-1-yl)-1H-imidazole DMVIQ7F MI TTBRKXS DMVIQ7F MN Adrenergic receptor alpha-1B (ADRA1B) DMVIQ7F MT DTT DMVIQ7F MA Inhibitor DMVIQ7F RN Medetomidine analogs as alpha 2-adrenergic ligands. 2. Design, synthesis, and biological activity of conformationally restricted naphthalene deriva... J Med Chem. 1996 Jul 19;39(15):3001-13. DMVIQ7F RU https://pubmed.ncbi.nlm.nih.gov/8709134 DMVIQ7F DI DMVIQ7F DMVIQ7F DN 4-(2,3-Dihydro-1H-phenalen-1-yl)-1H-imidazole DMVIQ7F MI TT34BHT DMVIQ7F MN Adrenergic receptor alpha-1D (ADRA1D) DMVIQ7F MT DTT DMVIQ7F MA Inhibitor DMVIQ7F RN Medetomidine analogs as alpha 2-adrenergic ligands. 2. Design, synthesis, and biological activity of conformationally restricted naphthalene deriva... J Med Chem. 1996 Jul 19;39(15):3001-13. DMVIQ7F RU https://pubmed.ncbi.nlm.nih.gov/8709134 DM6PMFJ DI DM6PMFJ DM6PMFJ DN 4-(2,3-Dimethoxy-phenoxy)-6,7-dimethoxy-quinoline DM6PMFJ MI TTI7421 DM6PMFJ MN Platelet-derived growth factor receptor beta (PDGFRB) DM6PMFJ MT DTT DM6PMFJ MA Inhibitor DM6PMFJ RN A novel series of 4-phenoxyquinolines: potent and highly selective inhibitors of PDGF receptor autophosphorylation, Bioorg. Med. Chem. Lett. 7(23):2935-2940 (1997). DM6PMFJ RU http://www.sciencedirect.com/science/article/pii/S0960894X97101172 DMPKE6G DI DMPKE6G DMPKE6G DN 4-(2,4-dichloro-phenoxy)-2'-methyl-biphenyl-3-ol DMPKE6G MI TTNX2CS DMPKE6G MN Plasmodium Enoyl-ACP reductase (Malaria fabI) DMPKE6G MT DTT DMPKE6G MA Inhibitor DMPKE6G RN X-ray structural analysis of Plasmodium falciparum enoyl acyl carrier protein reductase as a pathway toward the optimization of triclosan antimalar... J Biol Chem. 2007 Aug 31;282(35):25436-44. DMPKE6G RU https://pubmed.ncbi.nlm.nih.gov/17567585 DMS7POY DI DMS7POY DMS7POY DN 4-(2,4-dichlorophenoxy)-3-hydroxybenzonitrile DMS7POY MI TTNX2CS DMS7POY MN Plasmodium Enoyl-ACP reductase (Malaria fabI) DMS7POY MT DTT DMS7POY MA Inhibitor DMS7POY RN X-ray structural analysis of Plasmodium falciparum enoyl acyl carrier protein reductase as a pathway toward the optimization of triclosan antimalar... J Biol Chem. 2007 Aug 31;282(35):25436-44. DMS7POY RU https://pubmed.ncbi.nlm.nih.gov/17567585 DMY6GWF DI DMY6GWF DMY6GWF DN 4-(2,4-dichlorophenoxy)-3'-methylbiphenyl-3-ol DMY6GWF MI TTNX2CS DMY6GWF MN Plasmodium Enoyl-ACP reductase (Malaria fabI) DMY6GWF MT DTT DMY6GWF MA Inhibitor DMY6GWF RN Design and in silico screening of combinatorial library of antimalarial analogs of triclosan inhibiting Plasmodium falciparum enoyl-acyl carrier pr... Eur J Med Chem. 2009 Jul;44(7):3009-19. DMY6GWF RU https://pubmed.ncbi.nlm.nih.gov/19217192 DMAK789 DI DMAK789 DMAK789 DN 4-(2,4-dichloro-phenoxy)-4'-fluoro-biphenyl-3-ol DMAK789 MI TTNX2CS DMAK789 MN Plasmodium Enoyl-ACP reductase (Malaria fabI) DMAK789 MT DTT DMAK789 MA Inhibitor DMAK789 RN X-ray structural analysis of Plasmodium falciparum enoyl acyl carrier protein reductase as a pathway toward the optimization of triclosan antimalar... J Biol Chem. 2007 Aug 31;282(35):25436-44. DMAK789 RU https://pubmed.ncbi.nlm.nih.gov/17567585 DMRPVO3 DI DMRPVO3 DMRPVO3 DN 4-(2,4-dichlorophenoxy)-4'-methylbiphenyl-3-ol DMRPVO3 MI TTNX2CS DMRPVO3 MN Plasmodium Enoyl-ACP reductase (Malaria fabI) DMRPVO3 MT DTT DMRPVO3 MA Inhibitor DMRPVO3 RN Design and in silico screening of combinatorial library of antimalarial analogs of triclosan inhibiting Plasmodium falciparum enoyl-acyl carrier pr... Eur J Med Chem. 2009 Jul;44(7):3009-19. DMRPVO3 RU https://pubmed.ncbi.nlm.nih.gov/19217192 DMB96SY DI DMB96SY DMB96SY DN 4-(2,4-dichloro-phenoxy)-biphenyl-3-ol DMB96SY MI TTNX2CS DMB96SY MN Plasmodium Enoyl-ACP reductase (Malaria fabI) DMB96SY MT DTT DMB96SY MA Inhibitor DMB96SY RN X-ray structural analysis of Plasmodium falciparum enoyl acyl carrier protein reductase as a pathway toward the optimization of triclosan antimalar... J Biol Chem. 2007 Aug 31;282(35):25436-44. DMB96SY RU https://pubmed.ncbi.nlm.nih.gov/17567585 DMCGOPQ DI DMCGOPQ DMCGOPQ DN 4-(2,4-dichlorophenyl)-1-phenylpyrrolidin-3-amine DMCGOPQ MI TTDIGC1 DMCGOPQ MN Dipeptidyl peptidase 4 (DPP-4) DMCGOPQ MT DTT DMCGOPQ MA Inhibitor DMCGOPQ RN Pyrrolidine-constrained phenethylamines: The design of potent, selective, and pharmacologically efficacious dipeptidyl peptidase IV (DPP4) inhibito... Bioorg Med Chem Lett. 2007 Apr 1;17(7):2005-12. DMCGOPQ RU https://pubmed.ncbi.nlm.nih.gov/17276063 DMRMAOI DI DMRMAOI DMRMAOI DN 4-(2,4-dichlorophenyl)-1-tosylpyrrolidin-3-amine DMRMAOI MI TTDIGC1 DMRMAOI MN Dipeptidyl peptidase 4 (DPP-4) DMRMAOI MT DTT DMRMAOI MA Inhibitor DMRMAOI RN Pyrrolidine-constrained phenethylamines: The design of potent, selective, and pharmacologically efficacious dipeptidyl peptidase IV (DPP4) inhibito... Bioorg Med Chem Lett. 2007 Apr 1;17(7):2005-12. DMRMAOI RU https://pubmed.ncbi.nlm.nih.gov/17276063 DMBLAI1 DI DMBLAI1 DMBLAI1 DN 4-(2,4-diethyl-1H-pyrrol-3-yloxy)benzonitrile DMBLAI1 MI TTUV8G9 DMBLAI1 MN Progesterone receptor (PGR) DMBLAI1 MT DTT DMBLAI1 MA Inhibitor DMBLAI1 RN Optimisation of a pyrazole series of progesterone antagonists; Part 1. Bioorg Med Chem Lett. 2010 Jun 1;20(11):3384-6. DMBLAI1 RU https://pubmed.ncbi.nlm.nih.gov/20430618 DME8BLW DI DME8BLW DME8BLW DN 4-(2,4-Dimethyl-Thiazol-5-Yl)-Pyrimidin-2-Ylamine DME8BLW MI TT7HF4W DME8BLW MN Cyclin-dependent kinase 2 (CDK2) DME8BLW MT DTT DME8BLW MA Inhibitor DME8BLW RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DME8BLW RU https://pubmed.ncbi.nlm.nih.gov/17139284 DM3D8OK DI DM3D8OK DM3D8OK DN 4-(2,5-DIAMINO-5-HYDROXY-PENTYL)-PHENOL DM3D8OK MI TT6L509 DM3D8OK MN Coagulation factor IIa (F2) DM3D8OK MT DTT DM3D8OK MA Inhibitor DM3D8OK RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DM3D8OK RU https://pubmed.ncbi.nlm.nih.gov/10592235 DMKVH90 DI DMKVH90 DMKVH90 DN 4-(2,5-dichlorobenzylthio)-2-aminobutanoic acid DMKVH90 MI TTFK1JQ DMKVH90 MN Voltage-gated calcium channel alpha-2/delta-1 (CACNA2D1) DMKVH90 MT DTT DMKVH90 MA Inhibitor DMKVH90 RN Structure-activity relationships of alpha-amino acid ligands for the alpha2delta subunit of voltage-gated calcium channels. Bioorg Med Chem Lett. 2006 Mar 1;16(5):1138-41. DMKVH90 RU https://pubmed.ncbi.nlm.nih.gov/16380257 DMVYALJ DI DMVYALJ DMVYALJ DN 4-(2,5-Diphenyl-furan-3-yl)-morpholine DMVYALJ MI TTZ97H5 DMVYALJ MN Phosphodiesterase 4A (PDE4A) DMVYALJ MT DTT DMVYALJ MA Inhibitor DMVYALJ RN Substituted furans as inhibitors of the PDE4 enzyme. Bioorg Med Chem Lett. 1999 Feb 8;9(3):323-6. DMVYALJ RU https://pubmed.ncbi.nlm.nih.gov/10091677 DMH3TBQ DI DMH3TBQ DMH3TBQ DN 4-(2,6-diamino-9H-purin-8-yl)-2,6-dimethoxyphenol DMH3TBQ MI TT9SL3Q DMH3TBQ MN Polypeptide deformylase (PDF) DMH3TBQ MT DTT DMH3TBQ MA Inhibitor DMH3TBQ RN CoMFA analysis of tgDHFR and rlDHFR based on antifolates with 6-5 fused ring system using the all-orientation search (AOS) routine and a modified c... Bioorg Med Chem. 2010 Feb 15;18(4):1684-701. DMH3TBQ RU https://pubmed.ncbi.nlm.nih.gov/20117005 DMPLG9Q DI DMPLG9Q DMPLG9Q DN 4-(2,6-dimethylphenylthio)-2-methoxybenzonitrile DMPLG9Q MI TTKPW01 DMPLG9Q MN Androgen receptor messenger RNA (AR mRNA) DMPLG9Q MT DTT DMPLG9Q MA Inhibitor DMPLG9Q RN 4-(Alkylthio)- and 4-(arylthio)-benzonitrile derivatives as androgen receptor antagonists for the topical suppression of sebum production. Bioorg Med Chem Lett. 2009 Mar 1;19(5):1310-3. DMPLG9Q RU https://pubmed.ncbi.nlm.nih.gov/19201190 DMH5CAQ DI DMH5CAQ DMH5CAQ DN 4-(2-amino-1,3-thiazol-4-yl)phenol DMH5CAQ MI TTWHDVK DMH5CAQ MN Fructose-1,6-bisphosphatase (FBP) DMH5CAQ MT DTT DMH5CAQ MA Inhibitor DMH5CAQ RN A library of novel allosteric inhibitors against fructose 1,6-bisphosphatase. Bioorg Med Chem. 2009 Jun 1;17(11):3916-22. DMH5CAQ RU https://pubmed.ncbi.nlm.nih.gov/19419876 DMH5CAQ DI DMH5CAQ DMH5CAQ DN 4-(2-amino-1,3-thiazol-4-yl)phenol DMH5CAQ MI TTXZEAJ DMH5CAQ MN Leukotriene A-4 hydrolase (LTA4H) DMH5CAQ MT DTT DMH5CAQ MA Inhibitor DMH5CAQ RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DMH5CAQ RU https://pubmed.ncbi.nlm.nih.gov/10592235 DMWHDRI DI DMWHDRI DMWHDRI DN 4-(2-Aminoethyl) benzenesulfonyl fluoride DMWHDRI MI DTCSGPB DMWHDRI MN Multidrug resistance-associated protein 4 (ABCC4) DMWHDRI MT DTP DMWHDRI MA Substrate DMWHDRI RN Fluo-cAMP is transported by multidrug resistance-associated protein isoform 4 in rat choroid plexus. J Neurochem. 2010 Oct;115(1):200-8. DMWHDRI RU http://www.ncbi.nlm.nih.gov/pubmed/20649844 DMCS538 DI DMCS538 DMCS538 DN 4-(2-aminoethyl)-1,2,5-oxadiazol-3-ol DMCS538 MI TT1MPAY DMCS538 MN GABA(A) receptor alpha-1 (GABRA1) DMCS538 MT DTT DMCS538 MA Inhibitor DMCS538 RN Hydroxy-1,2,5-oxadiazolyl moiety as bioisoster of the carboxy function. Synthesis, ionization constants, and pharmacological characterization of ga... J Med Chem. 2006 Jul 13;49(14):4442-6. DMCS538 RU https://pubmed.ncbi.nlm.nih.gov/16821803 DMCS538 DI DMCS538 DMCS538 DN 4-(2-aminoethyl)-1,2,5-oxadiazol-3-ol DMCS538 MI TTZA1NY DMCS538 MN GABA(A) receptor beta-2 (GABRB2) DMCS538 MT DTT DMCS538 MA Inhibitor DMCS538 RN Hydroxy-1,2,5-oxadiazolyl moiety as bioisoster of the carboxy function. Synthesis, ionization constants, and pharmacological characterization of ga... J Med Chem. 2006 Jul 13;49(14):4442-6. DMCS538 RU https://pubmed.ncbi.nlm.nih.gov/16821803 DMCS538 DI DMCS538 DMCS538 DN 4-(2-aminoethyl)-1,2,5-oxadiazol-3-ol DMCS538 MI TT06RH5 DMCS538 MN GABA(A) receptor gamma-2 (GABRG2) DMCS538 MT DTT DMCS538 MA Inhibitor DMCS538 RN Hydroxy-1,2,5-oxadiazolyl moiety as bioisoster of the carboxy function. Synthesis, ionization constants, and pharmacological characterization of ga... J Med Chem. 2006 Jul 13;49(14):4442-6. DMCS538 RU https://pubmed.ncbi.nlm.nih.gov/16821803 DMCS538 DI DMCS538 DMCS538 DN 4-(2-aminoethyl)-1,2,5-oxadiazol-3-ol DMCS538 MI TTNJYV2 DMCS538 MN Gamma-aminobutyric acid receptor (GAR) DMCS538 MT DTT DMCS538 MA Inhibitor DMCS538 RN Hydroxy-1,2,5-oxadiazolyl moiety as bioisoster of the carboxy function. Synthesis, ionization constants, and pharmacological characterization of ga... J Med Chem. 2006 Jul 13;49(14):4442-6. DMCS538 RU https://pubmed.ncbi.nlm.nih.gov/16821803 DMZSN1Y DI DMZSN1Y DMZSN1Y DN 4-(2-aminoethyl)-2-cyclohexylphenol DMZSN1Y MI TT8JRS7 DMZSN1Y MN Beta-secretase (BACE) DMZSN1Y MT DTT DMZSN1Y MA Inhibitor DMZSN1Y RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DMZSN1Y RU https://pubmed.ncbi.nlm.nih.gov/10592235 DMF8D5S DI DMF8D5S DMF8D5S DN 4-(2-aminoethyl)-2-ethylphenol DMF8D5S MI TT8JRS7 DMF8D5S MN Beta-secretase (BACE) DMF8D5S MT DTT DMF8D5S MA Inhibitor DMF8D5S RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DMF8D5S RU https://pubmed.ncbi.nlm.nih.gov/10592235 DMEK6WX DI DMEK6WX DMEK6WX DN 4-(2-AMINOETHYL)BENZENESULFONAMIDE DMEK6WX MI TTUNARX DMEK6WX MN Carbonic anhydrase (CA) DMEK6WX MT DTT DMEK6WX MA Inhibitor DMEK6WX RN Carbonic anhydrase inhibitors. Inhibition of the human cytosolic isozyme VII with aromatic and heterocyclic sulfonamides. Bioorg Med Chem Lett. 2005 Feb 15;15(4):971-6. DMEK6WX RU https://pubmed.ncbi.nlm.nih.gov/15686895 DMEK6WX DI DMEK6WX DMEK6WX DN 4-(2-AMINOETHYL)BENZENESULFONAMIDE DMEK6WX MI TTHQPL7 DMEK6WX MN Carbonic anhydrase I (CA-I) DMEK6WX MT DTT DMEK6WX MA Inhibitor DMEK6WX RN Carbonic anhydrase inhibitors. Design of fluorescent sulfonamides as probes of tumor-associated carbonic anhydrase IX that inhibit isozyme IX-media... J Med Chem. 2005 Jul 28;48(15):4834-41. DMEK6WX RU https://pubmed.ncbi.nlm.nih.gov/16033263 DMEK6WX DI DMEK6WX DMEK6WX DN 4-(2-AMINOETHYL)BENZENESULFONAMIDE DMEK6WX MI TTANPDJ DMEK6WX MN Carbonic anhydrase II (CA-II) DMEK6WX MT DTT DMEK6WX MA Inhibitor DMEK6WX RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DMEK6WX RU https://pubmed.ncbi.nlm.nih.gov/10592235 DMEK6WX DI DMEK6WX DMEK6WX DN 4-(2-AMINOETHYL)BENZENESULFONAMIDE DMEK6WX MI TTZHA0O DMEK6WX MN Carbonic anhydrase IV (CA-IV) DMEK6WX MT DTT DMEK6WX MA Inhibitor DMEK6WX RN Carbonic anhydrase inhibitors. Inhibition of the membrane-bound human and bovine isozymes IV with sulfonamides. Bioorg Med Chem Lett. 2005 Feb 15;15(4):1149-54. DMEK6WX RU https://pubmed.ncbi.nlm.nih.gov/15686931 DMEK6WX DI DMEK6WX DMEK6WX DN 4-(2-AMINOETHYL)BENZENESULFONAMIDE DMEK6WX MI TT2LVK8 DMEK6WX MN Carbonic anhydrase IX (CA-IX) DMEK6WX MT DTT DMEK6WX MA Inhibitor DMEK6WX RN Carbonic anhydrase inhibitors. Design of fluorescent sulfonamides as probes of tumor-associated carbonic anhydrase IX that inhibit isozyme IX-media... J Med Chem. 2005 Jul 28;48(15):4834-41. DMEK6WX RU https://pubmed.ncbi.nlm.nih.gov/16033263 DMEK6WX DI DMEK6WX DMEK6WX DN 4-(2-AMINOETHYL)BENZENESULFONAMIDE DMEK6WX MI TTSYM0R DMEK6WX MN Carbonic anhydrase XII (CA-XII) DMEK6WX MT DTT DMEK6WX MA Inhibitor DMEK6WX RN Carbonic anhydrase inhibitors. Inhibition of the transmembrane isozyme XII with sulfonamides-a new target for the design of antitumor and antiglauc... Bioorg Med Chem Lett. 2005 Feb 15;15(4):963-9. DMEK6WX RU https://pubmed.ncbi.nlm.nih.gov/15686894 DMEK6WX DI DMEK6WX DMEK6WX DN 4-(2-AMINOETHYL)BENZENESULFONAMIDE DMEK6WX MI TTEYTKG DMEK6WX MN Carbonic anhydrase XIV (CA-XIV) DMEK6WX MT DTT DMEK6WX MA Inhibitor DMEK6WX RN Carbonic anhydrase inhibitors: inhibition of the transmembrane isozyme XIV with sulfonamides. Bioorg Med Chem Lett. 2005 Sep 1;15(17):3828-33. DMEK6WX RU https://pubmed.ncbi.nlm.nih.gov/16039848 DMWG706 DI DMWG706 DMWG706 DN 4-(2-aminopyrimidin-4-ylamino)benzenesulfonamide DMWG706 MI TTUNARX DMWG706 MN Carbonic anhydrase (CA) DMWG706 MT DTT DMWG706 MA Inhibitor DMWG706 RN Cloning, expression, post-translational modifications and inhibition studies on the latest mammalian carbonic anhydrase isoform, CA XV. J Med Chem. 2009 Feb 12;52(3):646-54. DMWG706 RU https://pubmed.ncbi.nlm.nih.gov/19193158 DMWG706 DI DMWG706 DMWG706 DN 4-(2-aminopyrimidin-4-ylamino)benzenesulfonamide DMWG706 MI TTHQPL7 DMWG706 MN Carbonic anhydrase I (CA-I) DMWG706 MT DTT DMWG706 MA Inhibitor DMWG706 RN Carbonic anhydrase inhibitors. Inhibition studies of a coral secretory isoform by sulfonamides. Bioorg Med Chem. 2009 Jul 15;17(14):5054-8. DMWG706 RU https://pubmed.ncbi.nlm.nih.gov/19520577 DMWG706 DI DMWG706 DMWG706 DN 4-(2-aminopyrimidin-4-ylamino)benzenesulfonamide DMWG706 MI TTANPDJ DMWG706 MN Carbonic anhydrase II (CA-II) DMWG706 MT DTT DMWG706 MA Inhibitor DMWG706 RN Carbonic anhydrase inhibitors. Characterization and inhibition studies of the most active beta-carbonic anhydrase from Mycobacterium tuberculosis, ... Bioorg Med Chem Lett. 2009 Dec 1;19(23):6649-54. DMWG706 RU https://pubmed.ncbi.nlm.nih.gov/19846301 DMWG706 DI DMWG706 DMWG706 DN 4-(2-aminopyrimidin-4-ylamino)benzenesulfonamide DMWG706 MI TT2LVK8 DMWG706 MN Carbonic anhydrase IX (CA-IX) DMWG706 MT DTT DMWG706 MA Inhibitor DMWG706 RN Cloning, expression, post-translational modifications and inhibition studies on the latest mammalian carbonic anhydrase isoform, CA XV. J Med Chem. 2009 Feb 12;52(3):646-54. DMWG706 RU https://pubmed.ncbi.nlm.nih.gov/19193158 DMWG706 DI DMWG706 DMWG706 DN 4-(2-aminopyrimidin-4-ylamino)benzenesulfonamide DMWG706 MI TTCFSPE DMWG706 MN Carbonic anhydrase VI (CA-VI) DMWG706 MT DTT DMWG706 MA Inhibitor DMWG706 RN Cloning, expression, post-translational modifications and inhibition studies on the latest mammalian carbonic anhydrase isoform, CA XV. J Med Chem. 2009 Feb 12;52(3):646-54. DMWG706 RU https://pubmed.ncbi.nlm.nih.gov/19193158 DMAZ0LV DI DMAZ0LV DMAZ0LV DN 4-(2-benzenesulfonylphenyl)piperazine DMAZ0LV MI TTJS8PY DMAZ0LV MN 5-HT 6 receptor (HTR6) DMAZ0LV MT DTT DMAZ0LV MA Inhibitor DMAZ0LV RN Binding of sulfonyl-containing arylalkylamines at human 5-HT6 serotonin receptors. J Med Chem. 2006 Aug 24;49(17):5217-25. DMAZ0LV RU https://pubmed.ncbi.nlm.nih.gov/16913710 DMYVD2E DI DMYVD2E DMYVD2E DN 4-(2-Benzylamino-ethoxy)-1,3-dihydro-indol-2-one DMYVD2E MI TTEX248 DMYVD2E MN Dopamine D2 receptor (D2R) DMYVD2E MT DTT DMYVD2E MA Inhibitor DMYVD2E RN New generation dopaminergic agents. 7. Heterocyclic bioisosteres that exploit the 3-OH-phenoxyethylamine D2 template. Bioorg Med Chem Lett. 1999 Sep 6;9(17):2593-8. DMYVD2E RU https://pubmed.ncbi.nlm.nih.gov/10498215 DMYVD2E DI DMYVD2E DMYVD2E DN 4-(2-Benzylamino-ethoxy)-1,3-dihydro-indol-2-one DMYVD2E MI TT4C8EA DMYVD2E MN Dopamine D3 receptor (D3R) DMYVD2E MT DTT DMYVD2E MA Inhibitor DMYVD2E RN New generation dopaminergic agents. 7. Heterocyclic bioisosteres that exploit the 3-OH-phenoxyethylamine D2 template. Bioorg Med Chem Lett. 1999 Sep 6;9(17):2593-8. DMYVD2E RU https://pubmed.ncbi.nlm.nih.gov/10498215 DMYVD2E DI DMYVD2E DMYVD2E DN 4-(2-Benzylamino-ethoxy)-1,3-dihydro-indol-2-one DMYVD2E MI TTE0A2F DMYVD2E MN Dopamine D4 receptor (D4R) DMYVD2E MT DTT DMYVD2E MA Inhibitor DMYVD2E RN New generation dopaminergic agents. 7. Heterocyclic bioisosteres that exploit the 3-OH-phenoxyethylamine D2 template. Bioorg Med Chem Lett. 1999 Sep 6;9(17):2593-8. DMYVD2E RU https://pubmed.ncbi.nlm.nih.gov/10498215 DMZ9TSR DI DMZ9TSR DMZ9TSR DN 4-(2-bromobenzylthio)-2-aminobutanoic acid DMZ9TSR MI TTFK1JQ DMZ9TSR MN Voltage-gated calcium channel alpha-2/delta-1 (CACNA2D1) DMZ9TSR MT DTT DMZ9TSR MA Inhibitor DMZ9TSR RN Structure-activity relationships of alpha-amino acid ligands for the alpha2delta subunit of voltage-gated calcium channels. Bioorg Med Chem Lett. 2006 Mar 1;16(5):1138-41. DMZ9TSR RU https://pubmed.ncbi.nlm.nih.gov/16380257 DM2MSEF DI DM2MSEF DM2MSEF DN 4'-(2-butylbenzofuran-3-yl)biphenyl-4-ol DM2MSEF MI TTELIN2 DM2MSEF MN PTPN1 messenger RNA (PTPN1 mRNA) DM2MSEF MT DTT DM2MSEF MA Inhibitor DM2MSEF RN Synthesis, activity and molecular modeling of a new series of chromones as low molecular weight protein tyrosine phosphatase inhibitors. Bioorg Med Chem. 2009 Apr 1;17(7):2658-72. DM2MSEF RU https://pubmed.ncbi.nlm.nih.gov/19297174 DM8HLEP DI DM8HLEP DM8HLEP DN 4-(2-Butyl-benzoimidazol-1-ylmethyl)-phenol DM8HLEP MI TT8DBY3 DM8HLEP MN Angiotensin II receptor type-1 (AGTR1) DM8HLEP MT DTT DM8HLEP MA Inhibitor DM8HLEP RN Discovery and development of aryl-fused imidazole-based angiotensin II antagonists, Bioorg. Med. Chem. Lett. 4(1):213-218 (1994). DM8HLEP RU http://www.sciencedirect.com/science/article/pii/S0960894X01811495 DM5L4WP DI DM5L4WP DM5L4WP DN 4-(2-carboxy-5-mercaptopentyl)benzoic acid DM5L4WP MI TT9G4N0 DM5L4WP MN Glutamate carboxypeptidase II (GCPII) DM5L4WP MT DTT DM5L4WP MA Inhibitor DM5L4WP RN Structural optimization of thiol-based inhibitors of glutamate carboxypeptidase II by modification of the P1' side chain. J Med Chem. 2006 May 18;49(10):2876-85. DM5L4WP RU https://pubmed.ncbi.nlm.nih.gov/16686531 DM82D9N DI DM82D9N DM82D9N DN 4-(2-cyanobenzylthio)-2-aminobutanoic acid DM82D9N MI TTFK1JQ DM82D9N MN Voltage-gated calcium channel alpha-2/delta-1 (CACNA2D1) DM82D9N MT DTT DM82D9N MA Inhibitor DM82D9N RN Structure-activity relationships of alpha-amino acid ligands for the alpha2delta subunit of voltage-gated calcium channels. Bioorg Med Chem Lett. 2006 Mar 1;16(5):1138-41. DM82D9N RU https://pubmed.ncbi.nlm.nih.gov/16380257 DMFJW2E DI DMFJW2E DMFJW2E DN 4-(2-Ethyl-4-m-tolyl-thiazol-5-yl)-pyridine DMFJW2E MI TTQBR95 DMFJW2E MN Stress-activated protein kinase 2a (p38 alpha) DMFJW2E MT DTT DMFJW2E MA Inhibitor DMFJW2E RN Novel inhibitor of p38 MAP kinase as an anti-TNF-alpha drug: discovery of N-[4-[2-ethyl-4-(3-methylphenyl)-1,3-thiazol-5-yl]-2-pyridyl]benzamide (T... J Med Chem. 2005 Sep 22;48(19):5966-79. DMFJW2E RU https://pubmed.ncbi.nlm.nih.gov/16162000 DMQUAP2 DI DMQUAP2 DMQUAP2 DN 4-(2-fluoro-6-(2-fluorophenoxy)phenyl)piperidine DMQUAP2 MI TTSQIFT DMQUAP2 MN 5-HT 1A receptor (HTR1A) DMQUAP2 MT DTT DMQUAP2 MA Inhibitor DMQUAP2 RN Design, synthesis, and pharmacological evaluation of phenoxy pyridyl derivatives as dual norepinephrine reuptake inhibitors and 5-HT1A partial agon... Bioorg Med Chem Lett. 2010 Feb 1;20(3):1114-7. DMQUAP2 RU https://pubmed.ncbi.nlm.nih.gov/20031410 DMQUAP2 DI DMQUAP2 DMQUAP2 DN 4-(2-fluoro-6-(2-fluorophenoxy)phenyl)piperidine DMQUAP2 MI TTVBI8W DMQUAP2 MN Dopamine transporter (DAT) DMQUAP2 MT DTT DMQUAP2 MA Inhibitor DMQUAP2 RN Design, synthesis, and pharmacological evaluation of phenoxy pyridyl derivatives as dual norepinephrine reuptake inhibitors and 5-HT1A partial agon... Bioorg Med Chem Lett. 2010 Feb 1;20(3):1114-7. DMQUAP2 RU https://pubmed.ncbi.nlm.nih.gov/20031410 DMQUAP2 DI DMQUAP2 DMQUAP2 DN 4-(2-fluoro-6-(2-fluorophenoxy)phenyl)piperidine DMQUAP2 MI TTAWNKZ DMQUAP2 MN Norepinephrine transporter (NET) DMQUAP2 MT DTT DMQUAP2 MA Inhibitor DMQUAP2 RN Design, synthesis, and pharmacological evaluation of phenoxy pyridyl derivatives as dual norepinephrine reuptake inhibitors and 5-HT1A partial agon... Bioorg Med Chem Lett. 2010 Feb 1;20(3):1114-7. DMQUAP2 RU https://pubmed.ncbi.nlm.nih.gov/20031410 DMQUAP2 DI DMQUAP2 DMQUAP2 DN 4-(2-fluoro-6-(2-fluorophenoxy)phenyl)piperidine DMQUAP2 MI TT3ROYC DMQUAP2 MN Serotonin transporter (SERT) DMQUAP2 MT DTT DMQUAP2 MA Inhibitor DMQUAP2 RN Design, synthesis, and pharmacological evaluation of phenoxy pyridyl derivatives as dual norepinephrine reuptake inhibitors and 5-HT1A partial agon... Bioorg Med Chem Lett. 2010 Feb 1;20(3):1114-7. DMQUAP2 RU https://pubmed.ncbi.nlm.nih.gov/20031410 DMUBHRF DI DMUBHRF DMUBHRF DN 4-(2-fluoro-6-(3-fluorophenoxy)phenyl)piperidine DMUBHRF MI TTSQIFT DMUBHRF MN 5-HT 1A receptor (HTR1A) DMUBHRF MT DTT DMUBHRF MA Inhibitor DMUBHRF RN Discovery and pharmacological characterization of aryl piperazine and piperidine ethers as dual acting norepinephrine reuptake inhibitors and 5-HT1... Bioorg Med Chem Lett. 2009 Dec 1;19(23):6604-7. DMUBHRF RU https://pubmed.ncbi.nlm.nih.gov/19854053 DMUBHRF DI DMUBHRF DMUBHRF DN 4-(2-fluoro-6-(3-fluorophenoxy)phenyl)piperidine DMUBHRF MI TTVBI8W DMUBHRF MN Dopamine transporter (DAT) DMUBHRF MT DTT DMUBHRF MA Inhibitor DMUBHRF RN Discovery and pharmacological characterization of aryl piperazine and piperidine ethers as dual acting norepinephrine reuptake inhibitors and 5-HT1... Bioorg Med Chem Lett. 2009 Dec 1;19(23):6604-7. DMUBHRF RU https://pubmed.ncbi.nlm.nih.gov/19854053 DMUBHRF DI DMUBHRF DMUBHRF DN 4-(2-fluoro-6-(3-fluorophenoxy)phenyl)piperidine DMUBHRF MI TTAWNKZ DMUBHRF MN Norepinephrine transporter (NET) DMUBHRF MT DTT DMUBHRF MA Inhibitor DMUBHRF RN Discovery and pharmacological characterization of aryl piperazine and piperidine ethers as dual acting norepinephrine reuptake inhibitors and 5-HT1... Bioorg Med Chem Lett. 2009 Dec 1;19(23):6604-7. DMUBHRF RU https://pubmed.ncbi.nlm.nih.gov/19854053 DMUBHRF DI DMUBHRF DMUBHRF DN 4-(2-fluoro-6-(3-fluorophenoxy)phenyl)piperidine DMUBHRF MI TT3ROYC DMUBHRF MN Serotonin transporter (SERT) DMUBHRF MT DTT DMUBHRF MA Inhibitor DMUBHRF RN Discovery and pharmacological characterization of aryl piperazine and piperidine ethers as dual acting norepinephrine reuptake inhibitors and 5-HT1... Bioorg Med Chem Lett. 2009 Dec 1;19(23):6604-7. DMUBHRF RU https://pubmed.ncbi.nlm.nih.gov/19854053 DMJ2GW0 DI DMJ2GW0 DMJ2GW0 DN 4-(2-fluoro-6-(4-fluorophenoxy)phenyl)piperidine DMJ2GW0 MI TTSQIFT DMJ2GW0 MN 5-HT 1A receptor (HTR1A) DMJ2GW0 MT DTT DMJ2GW0 MA Inhibitor DMJ2GW0 RN Discovery and pharmacological characterization of aryl piperazine and piperidine ethers as dual acting norepinephrine reuptake inhibitors and 5-HT1... Bioorg Med Chem Lett. 2009 Dec 1;19(23):6604-7. DMJ2GW0 RU https://pubmed.ncbi.nlm.nih.gov/19854053 DMJ2GW0 DI DMJ2GW0 DMJ2GW0 DN 4-(2-fluoro-6-(4-fluorophenoxy)phenyl)piperidine DMJ2GW0 MI TTVBI8W DMJ2GW0 MN Dopamine transporter (DAT) DMJ2GW0 MT DTT DMJ2GW0 MA Inhibitor DMJ2GW0 RN Discovery and pharmacological characterization of aryl piperazine and piperidine ethers as dual acting norepinephrine reuptake inhibitors and 5-HT1... Bioorg Med Chem Lett. 2009 Dec 1;19(23):6604-7. DMJ2GW0 RU https://pubmed.ncbi.nlm.nih.gov/19854053 DMJ2GW0 DI DMJ2GW0 DMJ2GW0 DN 4-(2-fluoro-6-(4-fluorophenoxy)phenyl)piperidine DMJ2GW0 MI TTAWNKZ DMJ2GW0 MN Norepinephrine transporter (NET) DMJ2GW0 MT DTT DMJ2GW0 MA Inhibitor DMJ2GW0 RN Discovery and pharmacological characterization of aryl piperazine and piperidine ethers as dual acting norepinephrine reuptake inhibitors and 5-HT1... Bioorg Med Chem Lett. 2009 Dec 1;19(23):6604-7. DMJ2GW0 RU https://pubmed.ncbi.nlm.nih.gov/19854053 DMJ2GW0 DI DMJ2GW0 DMJ2GW0 DN 4-(2-fluoro-6-(4-fluorophenoxy)phenyl)piperidine DMJ2GW0 MI TT3ROYC DMJ2GW0 MN Serotonin transporter (SERT) DMJ2GW0 MT DTT DMJ2GW0 MA Inhibitor DMJ2GW0 RN Discovery and pharmacological characterization of aryl piperazine and piperidine ethers as dual acting norepinephrine reuptake inhibitors and 5-HT1... Bioorg Med Chem Lett. 2009 Dec 1;19(23):6604-7. DMJ2GW0 RU https://pubmed.ncbi.nlm.nih.gov/19854053 DMXIGWC DI DMXIGWC DMXIGWC DN 4-(2-fluoro-6-phenoxyphenyl)piperidine DMXIGWC MI TTSQIFT DMXIGWC MN 5-HT 1A receptor (HTR1A) DMXIGWC MT DTT DMXIGWC MA Inhibitor DMXIGWC RN Discovery and pharmacological characterization of aryl piperazine and piperidine ethers as dual acting norepinephrine reuptake inhibitors and 5-HT1... Bioorg Med Chem Lett. 2009 Dec 1;19(23):6604-7. DMXIGWC RU https://pubmed.ncbi.nlm.nih.gov/19854053 DMXIGWC DI DMXIGWC DMXIGWC DN 4-(2-fluoro-6-phenoxyphenyl)piperidine DMXIGWC MI TTVBI8W DMXIGWC MN Dopamine transporter (DAT) DMXIGWC MT DTT DMXIGWC MA Inhibitor DMXIGWC RN Discovery and pharmacological characterization of aryl piperazine and piperidine ethers as dual acting norepinephrine reuptake inhibitors and 5-HT1... Bioorg Med Chem Lett. 2009 Dec 1;19(23):6604-7. DMXIGWC RU https://pubmed.ncbi.nlm.nih.gov/19854053 DMXIGWC DI DMXIGWC DMXIGWC DN 4-(2-fluoro-6-phenoxyphenyl)piperidine DMXIGWC MI TTAWNKZ DMXIGWC MN Norepinephrine transporter (NET) DMXIGWC MT DTT DMXIGWC MA Inhibitor DMXIGWC RN Discovery and pharmacological characterization of aryl piperazine and piperidine ethers as dual acting norepinephrine reuptake inhibitors and 5-HT1... Bioorg Med Chem Lett. 2009 Dec 1;19(23):6604-7. DMXIGWC RU https://pubmed.ncbi.nlm.nih.gov/19854053 DMXIGWC DI DMXIGWC DMXIGWC DN 4-(2-fluoro-6-phenoxyphenyl)piperidine DMXIGWC MI TT3ROYC DMXIGWC MN Serotonin transporter (SERT) DMXIGWC MT DTT DMXIGWC MA Inhibitor DMXIGWC RN Discovery and pharmacological characterization of aryl piperazine and piperidine ethers as dual acting norepinephrine reuptake inhibitors and 5-HT1... Bioorg Med Chem Lett. 2009 Dec 1;19(23):6604-7. DMXIGWC RU https://pubmed.ncbi.nlm.nih.gov/19854053 DMCWZF6 DI DMCWZF6 DMCWZF6 DN 4-(2-fluorophenylethynyl)-2-methylthiazole DMCWZF6 MI TTHS256 DMCWZF6 MN Metabotropic glutamate receptor 5 (mGluR5) DMCWZF6 MT DTT DMCWZF6 MA Inhibitor DMCWZF6 RN Synthesis and structure-activity relationships of 3-[(2-methyl-1,3-thiazol-4-yl)ethynyl]pyridine analogues as potent, noncompetitive metabotropic g... J Med Chem. 2006 Feb 9;49(3):1080-100. DMCWZF6 RU https://pubmed.ncbi.nlm.nih.gov/16451073 DM17QG8 DI DM17QG8 DM17QG8 DN 4-(2-Hydroxyethoxy)-1-naphthol DM17QG8 MI TTZJYKH DM17QG8 MN Indoleamine 2,3-dioxygenase 1 (IDO1) DM17QG8 MT DTT DM17QG8 MA Inhibitor DM17QG8 RN Rational design of indoleamine 2,3-dioxygenase inhibitors. J Med Chem. 2010 Feb 11;53(3):1172-89. DM17QG8 RU https://pubmed.ncbi.nlm.nih.gov/20055453 DM1C5U6 DI DM1C5U6 DM1C5U6 DN 4-(2-Hydroxy-ethyl)-benzenesulfonamide DM1C5U6 MI TTUNARX DM1C5U6 MN Carbonic anhydrase (CA) DM1C5U6 MT DTT DM1C5U6 MA Inhibitor DM1C5U6 RN Cloning, expression, post-translational modifications and inhibition studies on the latest mammalian carbonic anhydrase isoform, CA XV. J Med Chem. 2009 Feb 12;52(3):646-54. DM1C5U6 RU https://pubmed.ncbi.nlm.nih.gov/19193158 DM1C5U6 DI DM1C5U6 DM1C5U6 DN 4-(2-Hydroxy-ethyl)-benzenesulfonamide DM1C5U6 MI TTANPDJ DM1C5U6 MN Carbonic anhydrase II (CA-II) DM1C5U6 MT DTT DM1C5U6 MA Inhibitor DM1C5U6 RN Mutation of Phe91 to Asn in human carbonic anhydrase I unexpectedly enhanced both catalytic activity and affinity for sulfonamide inhibitors. Bioorg Med Chem. 2010 Aug 1;18(15):5498-503. DM1C5U6 RU https://pubmed.ncbi.nlm.nih.gov/20624682 DM1C5U6 DI DM1C5U6 DM1C5U6 DN 4-(2-Hydroxy-ethyl)-benzenesulfonamide DM1C5U6 MI TT2LVK8 DM1C5U6 MN Carbonic anhydrase IX (CA-IX) DM1C5U6 MT DTT DM1C5U6 MA Inhibitor DM1C5U6 RN Cloning, expression, post-translational modifications and inhibition studies on the latest mammalian carbonic anhydrase isoform, CA XV. J Med Chem. 2009 Feb 12;52(3):646-54. DM1C5U6 RU https://pubmed.ncbi.nlm.nih.gov/19193158 DM1C5U6 DI DM1C5U6 DM1C5U6 DN 4-(2-Hydroxy-ethyl)-benzenesulfonamide DM1C5U6 MI TTCFSPE DM1C5U6 MN Carbonic anhydrase VI (CA-VI) DM1C5U6 MT DTT DM1C5U6 MA Inhibitor DM1C5U6 RN Cloning, expression, post-translational modifications and inhibition studies on the latest mammalian carbonic anhydrase isoform, CA XV. J Med Chem. 2009 Feb 12;52(3):646-54. DM1C5U6 RU https://pubmed.ncbi.nlm.nih.gov/19193158 DM1C5U6 DI DM1C5U6 DM1C5U6 DN 4-(2-Hydroxy-ethyl)-benzenesulfonamide DM1C5U6 MI TTSYM0R DM1C5U6 MN Carbonic anhydrase XII (CA-XII) DM1C5U6 MT DTT DM1C5U6 MA Inhibitor DM1C5U6 RN Carbonic anhydrase inhibitors. Inhibition of the transmembrane isozyme XII with sulfonamides-a new target for the design of antitumor and antiglauc... Bioorg Med Chem Lett. 2005 Feb 15;15(4):963-9. DM1C5U6 RU https://pubmed.ncbi.nlm.nih.gov/15686894 DM1C5U6 DI DM1C5U6 DM1C5U6 DN 4-(2-Hydroxy-ethyl)-benzenesulfonamide DM1C5U6 MI TTEYTKG DM1C5U6 MN Carbonic anhydrase XIV (CA-XIV) DM1C5U6 MT DTT DM1C5U6 MA Inhibitor DM1C5U6 RN Carbonic anhydrase inhibitors: inhibition of the transmembrane isozyme XIV with sulfonamides. Bioorg Med Chem Lett. 2005 Sep 1;15(17):3828-33. DM1C5U6 RU https://pubmed.ncbi.nlm.nih.gov/16039848 DMB6SNE DI DMB6SNE DMB6SNE DN 4-(2-Imidazol-1-yl-ethoxy)-benzamide DMB6SNE MI TTIQUX7 DMB6SNE MN Steroid 11-beta-hydroxylase (CYP11B1) DMB6SNE MT DTT DMB6SNE MA Inhibitor DMB6SNE RN Selective thromboxane synthetase inhibitors. 1. 1-[(Aryloxy)alkyl]-1H-imidazoles. J Med Chem. 1985 Oct;28(10):1427-32. DMB6SNE RU https://pubmed.ncbi.nlm.nih.gov/3930740 DMNSKXR DI DMNSKXR DMNSKXR DN 4-(2-methoxybenzylthio)-2-aminobutanoic acid DMNSKXR MI TTFK1JQ DMNSKXR MN Voltage-gated calcium channel alpha-2/delta-1 (CACNA2D1) DMNSKXR MT DTT DMNSKXR MA Inhibitor DMNSKXR RN Structure-activity relationships of alpha-amino acid ligands for the alpha2delta subunit of voltage-gated calcium channels. Bioorg Med Chem Lett. 2006 Mar 1;16(5):1138-41. DMNSKXR RU https://pubmed.ncbi.nlm.nih.gov/16380257 DM9WQOJ DI DM9WQOJ DM9WQOJ DN 4-(2-methoxyethoxy)-6-methylpyrimidin-2-amine DM9WQOJ MI TT78R5H DM9WQOJ MN Heat shock protein 90 alpha (HSP90A) DM9WQOJ MT DTT DM9WQOJ MA Inhibitor DM9WQOJ RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DM9WQOJ RU https://pubmed.ncbi.nlm.nih.gov/10592235 DMFVYHI DI DMFVYHI DMFVYHI DN 4-(2-methoxyphenylethynyl)-2-methylthiazole DMFVYHI MI TTHS256 DMFVYHI MN Metabotropic glutamate receptor 5 (mGluR5) DMFVYHI MT DTT DMFVYHI MA Inhibitor DMFVYHI RN Synthesis and structure-activity relationships of 3-[(2-methyl-1,3-thiazol-4-yl)ethynyl]pyridine analogues as potent, noncompetitive metabotropic g... J Med Chem. 2006 Feb 9;49(3):1080-100. DMFVYHI RU https://pubmed.ncbi.nlm.nih.gov/16451073 DM6DSNI DI DM6DSNI DM6DSNI DN 4'-(2-methyl-1-(pyridin-4-yl)propyl)biphenyl-3-ol DM6DSNI MI TTRA5BZ DM6DSNI MN Steroid 17-alpha-monooxygenase (S17AH) DM6DSNI MT DTT DM6DSNI MA Inhibitor DM6DSNI RN Isopropylidene substitution increases activity and selectivity of biphenylmethylene 4-pyridine type CYP17 inhibitors. J Med Chem. 2010 Jul 8;53(13):5049-53. DM6DSNI RU https://pubmed.ncbi.nlm.nih.gov/20550118 DME6DHX DI DME6DHX DME6DHX DN 4-(2-Methyl-8-quinolinoxy)-3-pyridinesulfonamide DME6DHX MI TTHQPL7 DME6DHX MN Carbonic anhydrase I (CA-I) DME6DHX MT DTT DME6DHX MA Inhibitor DME6DHX RN Carbonic anhydrase inhibitors: synthesis and inhibition of the human cytosolic isozymes I and II and transmembrane isozymes IX, XII (cancer-associa... Eur J Med Chem. 2010 Jun;45(6):2396-404. DME6DHX RU https://pubmed.ncbi.nlm.nih.gov/20202722 DME6DHX DI DME6DHX DME6DHX DN 4-(2-Methyl-8-quinolinoxy)-3-pyridinesulfonamide DME6DHX MI TTANPDJ DME6DHX MN Carbonic anhydrase II (CA-II) DME6DHX MT DTT DME6DHX MA Inhibitor DME6DHX RN Carbonic anhydrase inhibitors: synthesis and inhibition of the human cytosolic isozymes I and II and transmembrane isozymes IX, XII (cancer-associa... Eur J Med Chem. 2010 Jun;45(6):2396-404. DME6DHX RU https://pubmed.ncbi.nlm.nih.gov/20202722 DME6DHX DI DME6DHX DME6DHX DN 4-(2-Methyl-8-quinolinoxy)-3-pyridinesulfonamide DME6DHX MI TT2LVK8 DME6DHX MN Carbonic anhydrase IX (CA-IX) DME6DHX MT DTT DME6DHX MA Inhibitor DME6DHX RN Carbonic anhydrase inhibitors: synthesis and inhibition of the human cytosolic isozymes I and II and transmembrane isozymes IX, XII (cancer-associa... Eur J Med Chem. 2010 Jun;45(6):2396-404. DME6DHX RU https://pubmed.ncbi.nlm.nih.gov/20202722 DME6DHX DI DME6DHX DME6DHX DN 4-(2-Methyl-8-quinolinoxy)-3-pyridinesulfonamide DME6DHX MI TTSYM0R DME6DHX MN Carbonic anhydrase XII (CA-XII) DME6DHX MT DTT DME6DHX MA Inhibitor DME6DHX RN Carbonic anhydrase inhibitors: synthesis and inhibition of the human cytosolic isozymes I and II and transmembrane isozymes IX, XII (cancer-associa... Eur J Med Chem. 2010 Jun;45(6):2396-404. DME6DHX RU https://pubmed.ncbi.nlm.nih.gov/20202722 DME6DHX DI DME6DHX DME6DHX DN 4-(2-Methyl-8-quinolinoxy)-3-pyridinesulfonamide DME6DHX MI TTEYTKG DME6DHX MN Carbonic anhydrase XIV (CA-XIV) DME6DHX MT DTT DME6DHX MA Inhibitor DME6DHX RN Carbonic anhydrase inhibitors: synthesis and inhibition of the human cytosolic isozymes I and II and transmembrane isozymes IX, XII (cancer-associa... Eur J Med Chem. 2010 Jun;45(6):2396-404. DME6DHX RU https://pubmed.ncbi.nlm.nih.gov/20202722 DMEAV9Q DI DMEAV9Q DMEAV9Q DN 4-(2-Methyl-thiazol-4-ylethynyl)-pyridine DMEAV9Q MI TTHS256 DMEAV9Q MN Metabotropic glutamate receptor 5 (mGluR5) DMEAV9Q MT DTT DMEAV9Q MA Inhibitor DMEAV9Q RN 5-[(2-Methyl-1,3-thiazol-4-yl)ethynyl]-2,3'-bipyridine: a highly potent, orally active metabotropic glutamate subtype 5 (mGlu5) receptor antagonist... Bioorg Med Chem Lett. 2004 Aug 2;14(15):3993-6. DMEAV9Q RU https://pubmed.ncbi.nlm.nih.gov/15225713 DMC1KEG DI DMC1KEG DMC1KEG DN 4-(2-nitrobenzylthio)-2-aminobutanoic acid DMC1KEG MI TTFK1JQ DMC1KEG MN Voltage-gated calcium channel alpha-2/delta-1 (CACNA2D1) DMC1KEG MT DTT DMC1KEG MA Inhibitor DMC1KEG RN Structure-activity relationships of alpha-amino acid ligands for the alpha2delta subunit of voltage-gated calcium channels. Bioorg Med Chem Lett. 2006 Mar 1;16(5):1138-41. DMC1KEG RU https://pubmed.ncbi.nlm.nih.gov/16380257 DMCHTI0 DI DMCHTI0 DMCHTI0 DN 4-(2-nitroprop-1-enyl)benzene-1,2-diol DMCHTI0 MI TTGKNB4 DMCHTI0 MN Epidermal growth factor receptor (EGFR) DMCHTI0 MT DTT DMCHTI0 MA Inhibitor DMCHTI0 RN Protein-tyrosine kinase inhibition: mechanism-based discovery of antitumor agents. J Nat Prod. 1992 Nov;55(11):1529-60. DMCHTI0 RU https://pubmed.ncbi.nlm.nih.gov/1479375 DM62ZRE DI DM62ZRE DM62ZRE DN 4-(2-nitrovinyl)benzene-1,2-diol DM62ZRE MI TTGKNB4 DM62ZRE MN Epidermal growth factor receptor (EGFR) DM62ZRE MT DTT DM62ZRE MA Inhibitor DM62ZRE RN Protein-tyrosine kinase inhibition: mechanism-based discovery of antitumor agents. J Nat Prod. 1992 Nov;55(11):1529-60. DM62ZRE RU https://pubmed.ncbi.nlm.nih.gov/1479375 DMPTVR2 DI DMPTVR2 DMPTVR2 DN 4-(2-nitrovinyl)phenol DMPTVR2 MI TTGKNB4 DMPTVR2 MN Epidermal growth factor receptor (EGFR) DMPTVR2 MT DTT DMPTVR2 MA Inhibitor DMPTVR2 RN Protein-tyrosine kinase inhibition: mechanism-based discovery of antitumor agents. J Nat Prod. 1992 Nov;55(11):1529-60. DMPTVR2 RU https://pubmed.ncbi.nlm.nih.gov/1479375 DMWIALU DI DMWIALU DMWIALU DN 4-(2-oxo-2H-chromene-3-carboxamido)benzoic acid DMWIALU MI TT3WG5C DMWIALU MN Monoamine oxidase type A (MAO-A) DMWIALU MT DTT DMWIALU MA Inhibitor DMWIALU RN Synthesis, molecular modeling, and selective inhibitory activity against human monoamine oxidases of 3-carboxamido-7-substituted coumarins. J Med Chem. 2009 Apr 9;52(7):1935-42. DMWIALU RU https://pubmed.ncbi.nlm.nih.gov/19267475 DMWIALU DI DMWIALU DMWIALU DN 4-(2-oxo-2H-chromene-3-carboxamido)benzoic acid DMWIALU MI TTGP7BY DMWIALU MN Monoamine oxidase type B (MAO-B) DMWIALU MT DTT DMWIALU MA Inhibitor DMWIALU RN Synthesis, molecular modeling, and selective inhibitory activity against human monoamine oxidases of 3-carboxamido-7-substituted coumarins. J Med Chem. 2009 Apr 9;52(7):1935-42. DMWIALU RU https://pubmed.ncbi.nlm.nih.gov/19267475 DMFPNQ9 DI DMFPNQ9 DMFPNQ9 DN 4-(2-Oxo-2-phenyl-acetyl)-benzoic acid DMFPNQ9 MI TTMF541 DMFPNQ9 MN Liver carboxylesterase (CES1) DMFPNQ9 MT DTT DMFPNQ9 MA Inhibitor DMFPNQ9 RN Identification and characterization of novel benzil (diphenylethane-1,2-dione) analogues as inhibitors of mammalian carboxylesterases. J Med Chem. 2005 Apr 21;48(8):2906-15. DMFPNQ9 RU https://pubmed.ncbi.nlm.nih.gov/15828829 DMBMJC5 DI DMBMJC5 DMBMJC5 DN 4-(2-oxohexadecanamido)butanoic acid DMBMJC5 MI TTT1JVS DMBMJC5 MN Cytosolic phospholipase A2 (GIVA cPLA2) DMBMJC5 MT DTT DMBMJC5 MA Inhibitor DMBMJC5 RN Discovery of Ecopladib, an indole inhibitor of cytosolic phospholipase A2alpha. J Med Chem. 2007 Mar 22;50(6):1380-400. DMBMJC5 RU https://pubmed.ncbi.nlm.nih.gov/17305324 DMB5IFA DI DMB5IFA DMB5IFA DN 4-(2-phenoxyphenyl)piperidine DMB5IFA MI TTSQIFT DMB5IFA MN 5-HT 1A receptor (HTR1A) DMB5IFA MT DTT DMB5IFA MA Inhibitor DMB5IFA RN Discovery and pharmacological characterization of aryl piperazine and piperidine ethers as dual acting norepinephrine reuptake inhibitors and 5-HT1... Bioorg Med Chem Lett. 2009 Dec 1;19(23):6604-7. DMB5IFA RU https://pubmed.ncbi.nlm.nih.gov/19854053 DMB5IFA DI DMB5IFA DMB5IFA DN 4-(2-phenoxyphenyl)piperidine DMB5IFA MI TTVBI8W DMB5IFA MN Dopamine transporter (DAT) DMB5IFA MT DTT DMB5IFA MA Inhibitor DMB5IFA RN Discovery and pharmacological characterization of aryl piperazine and piperidine ethers as dual acting norepinephrine reuptake inhibitors and 5-HT1... Bioorg Med Chem Lett. 2009 Dec 1;19(23):6604-7. DMB5IFA RU https://pubmed.ncbi.nlm.nih.gov/19854053 DMB5IFA DI DMB5IFA DMB5IFA DN 4-(2-phenoxyphenyl)piperidine DMB5IFA MI TTAWNKZ DMB5IFA MN Norepinephrine transporter (NET) DMB5IFA MT DTT DMB5IFA MA Inhibitor DMB5IFA RN Discovery and pharmacological characterization of aryl piperazine and piperidine ethers as dual acting norepinephrine reuptake inhibitors and 5-HT1... Bioorg Med Chem Lett. 2009 Dec 1;19(23):6604-7. DMB5IFA RU https://pubmed.ncbi.nlm.nih.gov/19854053 DMB5IFA DI DMB5IFA DMB5IFA DN 4-(2-phenoxyphenyl)piperidine DMB5IFA MI TT3ROYC DMB5IFA MN Serotonin transporter (SERT) DMB5IFA MT DTT DMB5IFA MA Inhibitor DMB5IFA RN Discovery and pharmacological characterization of aryl piperazine and piperidine ethers as dual acting norepinephrine reuptake inhibitors and 5-HT1... Bioorg Med Chem Lett. 2009 Dec 1;19(23):6604-7. DMB5IFA RU https://pubmed.ncbi.nlm.nih.gov/19854053 DMFQZOI DI DMFQZOI DMFQZOI DN 4-(2-phenyl-1H-benzo[d]imidazol-1-yl)phenol DMFQZOI MI TTZAYWL DMFQZOI MN Estrogen receptor (ESR) DMFQZOI MT DTT DMFQZOI MA Inhibitor DMFQZOI RN Estrogen receptor beta selective ligands: discovery and SAR of novel heterocyclic ligands. Bioorg Med Chem Lett. 2005 Dec 15;15(24):5562-6. DMFQZOI RU https://pubmed.ncbi.nlm.nih.gov/16219463 DMFQZOI DI DMFQZOI DMFQZOI DN 4-(2-phenyl-1H-benzo[d]imidazol-1-yl)phenol DMFQZOI MI TTOM3J0 DMFQZOI MN Estrogen receptor beta (ESR2) DMFQZOI MT DTT DMFQZOI MA Inhibitor DMFQZOI RN Estrogen receptor beta selective ligands: discovery and SAR of novel heterocyclic ligands. Bioorg Med Chem Lett. 2005 Dec 15;15(24):5562-6. DMFQZOI RU https://pubmed.ncbi.nlm.nih.gov/16219463 DMCPSE9 DI DMCPSE9 DMCPSE9 DN 4-(2-phenyl-1H-indol-3-yl)phenol DMCPSE9 MI TTZAYWL DMCPSE9 MN Estrogen receptor (ESR) DMCPSE9 MT DTT DMCPSE9 MA Inhibitor DMCPSE9 RN Estrogen receptor beta selective ligands: discovery and SAR of novel heterocyclic ligands. Bioorg Med Chem Lett. 2005 Dec 15;15(24):5562-6. DMCPSE9 RU https://pubmed.ncbi.nlm.nih.gov/16219463 DMCPSE9 DI DMCPSE9 DMCPSE9 DN 4-(2-phenyl-1H-indol-3-yl)phenol DMCPSE9 MI TTOM3J0 DMCPSE9 MN Estrogen receptor beta (ESR2) DMCPSE9 MT DTT DMCPSE9 MA Inhibitor DMCPSE9 RN Estrogen receptor beta selective ligands: discovery and SAR of novel heterocyclic ligands. Bioorg Med Chem Lett. 2005 Dec 15;15(24):5562-6. DMCPSE9 RU https://pubmed.ncbi.nlm.nih.gov/16219463 DMZ62L3 DI DMZ62L3 DMZ62L3 DN 4-(2-Phenylacetamido)-3-bromobenzenesulfonamide DMZ62L3 MI TTUNARX DMZ62L3 MN Carbonic anhydrase (CA) DMZ62L3 MT DTT DMZ62L3 MA Inhibitor DMZ62L3 RN Carbonic anhydrase inhibitors. Aromatic/heterocyclic sulfonamides incorporating phenacetyl, pyridylacetyl and thienylacetyl tails act as potent inh... Bioorg Med Chem. 2009 Jul 15;17(14):4894-9. DMZ62L3 RU https://pubmed.ncbi.nlm.nih.gov/19539481 DMZ62L3 DI DMZ62L3 DMZ62L3 DN 4-(2-Phenylacetamido)-3-bromobenzenesulfonamide DMZ62L3 MI TTHQPL7 DMZ62L3 MN Carbonic anhydrase I (CA-I) DMZ62L3 MT DTT DMZ62L3 MA Inhibitor DMZ62L3 RN Carbonic anhydrase inhibitors. Aromatic/heterocyclic sulfonamides incorporating phenacetyl, pyridylacetyl and thienylacetyl tails act as potent inh... Bioorg Med Chem. 2009 Jul 15;17(14):4894-9. DMZ62L3 RU https://pubmed.ncbi.nlm.nih.gov/19539481 DMZ62L3 DI DMZ62L3 DMZ62L3 DN 4-(2-Phenylacetamido)-3-bromobenzenesulfonamide DMZ62L3 MI TTANPDJ DMZ62L3 MN Carbonic anhydrase II (CA-II) DMZ62L3 MT DTT DMZ62L3 MA Inhibitor DMZ62L3 RN Carbonic anhydrase inhibitors. Aromatic/heterocyclic sulfonamides incorporating phenacetyl, pyridylacetyl and thienylacetyl tails act as potent inh... Bioorg Med Chem. 2009 Jul 15;17(14):4894-9. DMZ62L3 RU https://pubmed.ncbi.nlm.nih.gov/19539481 DM9GOTA DI DM9GOTA DM9GOTA DN 4-(2-Phenylacetamido)-3-chlorobenzenesulfonamide DM9GOTA MI TTUNARX DM9GOTA MN Carbonic anhydrase (CA) DM9GOTA MT DTT DM9GOTA MA Inhibitor DM9GOTA RN Carbonic anhydrase inhibitors. Aromatic/heterocyclic sulfonamides incorporating phenacetyl, pyridylacetyl and thienylacetyl tails act as potent inh... Bioorg Med Chem. 2009 Jul 15;17(14):4894-9. DM9GOTA RU https://pubmed.ncbi.nlm.nih.gov/19539481 DM9GOTA DI DM9GOTA DM9GOTA DN 4-(2-Phenylacetamido)-3-chlorobenzenesulfonamide DM9GOTA MI TTHQPL7 DM9GOTA MN Carbonic anhydrase I (CA-I) DM9GOTA MT DTT DM9GOTA MA Inhibitor DM9GOTA RN Carbonic anhydrase inhibitors. Aromatic/heterocyclic sulfonamides incorporating phenacetyl, pyridylacetyl and thienylacetyl tails act as potent inh... Bioorg Med Chem. 2009 Jul 15;17(14):4894-9. DM9GOTA RU https://pubmed.ncbi.nlm.nih.gov/19539481 DM9GOTA DI DM9GOTA DM9GOTA DN 4-(2-Phenylacetamido)-3-chlorobenzenesulfonamide DM9GOTA MI TTANPDJ DM9GOTA MN Carbonic anhydrase II (CA-II) DM9GOTA MT DTT DM9GOTA MA Inhibitor DM9GOTA RN Carbonic anhydrase inhibitors. Aromatic/heterocyclic sulfonamides incorporating phenacetyl, pyridylacetyl and thienylacetyl tails act as potent inh... Bioorg Med Chem. 2009 Jul 15;17(14):4894-9. DM9GOTA RU https://pubmed.ncbi.nlm.nih.gov/19539481 DMCOD4N DI DMCOD4N DMCOD4N DN 4-(2-Phenylacetamido)-3-fluorobenzenesulfonamide DMCOD4N MI TTUNARX DMCOD4N MN Carbonic anhydrase (CA) DMCOD4N MT DTT DMCOD4N MA Inhibitor DMCOD4N RN Carbonic anhydrase inhibitors. Aromatic/heterocyclic sulfonamides incorporating phenacetyl, pyridylacetyl and thienylacetyl tails act as potent inh... Bioorg Med Chem. 2009 Jul 15;17(14):4894-9. DMCOD4N RU https://pubmed.ncbi.nlm.nih.gov/19539481 DMCOD4N DI DMCOD4N DMCOD4N DN 4-(2-Phenylacetamido)-3-fluorobenzenesulfonamide DMCOD4N MI TTHQPL7 DMCOD4N MN Carbonic anhydrase I (CA-I) DMCOD4N MT DTT DMCOD4N MA Inhibitor DMCOD4N RN Carbonic anhydrase inhibitors. Aromatic/heterocyclic sulfonamides incorporating phenacetyl, pyridylacetyl and thienylacetyl tails act as potent inh... Bioorg Med Chem. 2009 Jul 15;17(14):4894-9. DMCOD4N RU https://pubmed.ncbi.nlm.nih.gov/19539481 DMCOD4N DI DMCOD4N DMCOD4N DN 4-(2-Phenylacetamido)-3-fluorobenzenesulfonamide DMCOD4N MI TTANPDJ DMCOD4N MN Carbonic anhydrase II (CA-II) DMCOD4N MT DTT DMCOD4N MA Inhibitor DMCOD4N RN Carbonic anhydrase inhibitors. Aromatic/heterocyclic sulfonamides incorporating phenacetyl, pyridylacetyl and thienylacetyl tails act as potent inh... Bioorg Med Chem. 2009 Jul 15;17(14):4894-9. DMCOD4N RU https://pubmed.ncbi.nlm.nih.gov/19539481 DMFYR6H DI DMFYR6H DMFYR6H DN 4-(2-Phenylacetamido)benzenesulfonamide DMFYR6H MI TTUNARX DMFYR6H MN Carbonic anhydrase (CA) DMFYR6H MT DTT DMFYR6H MA Inhibitor DMFYR6H RN Carbonic anhydrase inhibitors. Aromatic/heterocyclic sulfonamides incorporating phenacetyl, pyridylacetyl and thienylacetyl tails act as potent inh... Bioorg Med Chem. 2009 Jul 15;17(14):4894-9. DMFYR6H RU https://pubmed.ncbi.nlm.nih.gov/19539481 DMFYR6H DI DMFYR6H DMFYR6H DN 4-(2-Phenylacetamido)benzenesulfonamide DMFYR6H MI TTHQPL7 DMFYR6H MN Carbonic anhydrase I (CA-I) DMFYR6H MT DTT DMFYR6H MA Inhibitor DMFYR6H RN Carbonic anhydrase inhibitors. Aromatic/heterocyclic sulfonamides incorporating phenacetyl, pyridylacetyl and thienylacetyl tails act as potent inh... Bioorg Med Chem. 2009 Jul 15;17(14):4894-9. DMFYR6H RU https://pubmed.ncbi.nlm.nih.gov/19539481 DMFYR6H DI DMFYR6H DMFYR6H DN 4-(2-Phenylacetamido)benzenesulfonamide DMFYR6H MI TTANPDJ DMFYR6H MN Carbonic anhydrase II (CA-II) DMFYR6H MT DTT DMFYR6H MA Inhibitor DMFYR6H RN Carbonic anhydrase inhibitors. Aromatic/heterocyclic sulfonamides incorporating phenacetyl, pyridylacetyl and thienylacetyl tails act as potent inh... Bioorg Med Chem. 2009 Jul 15;17(14):4894-9. DMFYR6H RU https://pubmed.ncbi.nlm.nih.gov/19539481 DM1JL03 DI DM1JL03 DM1JL03 DN 4-(2-Phenylacetamidoethyl)benzenesulfonamide DM1JL03 MI TTUNARX DM1JL03 MN Carbonic anhydrase (CA) DM1JL03 MT DTT DM1JL03 MA Inhibitor DM1JL03 RN Carbonic anhydrase inhibitors. Aromatic/heterocyclic sulfonamides incorporating phenacetyl, pyridylacetyl and thienylacetyl tails act as potent inh... Bioorg Med Chem. 2009 Jul 15;17(14):4894-9. DM1JL03 RU https://pubmed.ncbi.nlm.nih.gov/19539481 DM1JL03 DI DM1JL03 DM1JL03 DN 4-(2-Phenylacetamidoethyl)benzenesulfonamide DM1JL03 MI TTHQPL7 DM1JL03 MN Carbonic anhydrase I (CA-I) DM1JL03 MT DTT DM1JL03 MA Inhibitor DM1JL03 RN Carbonic anhydrase inhibitors. Aromatic/heterocyclic sulfonamides incorporating phenacetyl, pyridylacetyl and thienylacetyl tails act as potent inh... Bioorg Med Chem. 2009 Jul 15;17(14):4894-9. DM1JL03 RU https://pubmed.ncbi.nlm.nih.gov/19539481 DM1JL03 DI DM1JL03 DM1JL03 DN 4-(2-Phenylacetamidoethyl)benzenesulfonamide DM1JL03 MI TTANPDJ DM1JL03 MN Carbonic anhydrase II (CA-II) DM1JL03 MT DTT DM1JL03 MA Inhibitor DM1JL03 RN Carbonic anhydrase inhibitors. Aromatic/heterocyclic sulfonamides incorporating phenacetyl, pyridylacetyl and thienylacetyl tails act as potent inh... Bioorg Med Chem. 2009 Jul 15;17(14):4894-9. DM1JL03 RU https://pubmed.ncbi.nlm.nih.gov/19539481 DMDYHXE DI DMDYHXE DMDYHXE DN 4-(2-Phenylacetamidomethyl)benzenesulfonamide DMDYHXE MI TTUNARX DMDYHXE MN Carbonic anhydrase (CA) DMDYHXE MT DTT DMDYHXE MA Inhibitor DMDYHXE RN Carbonic anhydrase inhibitors. Aromatic/heterocyclic sulfonamides incorporating phenacetyl, pyridylacetyl and thienylacetyl tails act as potent inh... Bioorg Med Chem. 2009 Jul 15;17(14):4894-9. DMDYHXE RU https://pubmed.ncbi.nlm.nih.gov/19539481 DMDYHXE DI DMDYHXE DMDYHXE DN 4-(2-Phenylacetamidomethyl)benzenesulfonamide DMDYHXE MI TTHQPL7 DMDYHXE MN Carbonic anhydrase I (CA-I) DMDYHXE MT DTT DMDYHXE MA Inhibitor DMDYHXE RN Carbonic anhydrase inhibitors. Aromatic/heterocyclic sulfonamides incorporating phenacetyl, pyridylacetyl and thienylacetyl tails act as potent inh... Bioorg Med Chem. 2009 Jul 15;17(14):4894-9. DMDYHXE RU https://pubmed.ncbi.nlm.nih.gov/19539481 DMDYHXE DI DMDYHXE DMDYHXE DN 4-(2-Phenylacetamidomethyl)benzenesulfonamide DMDYHXE MI TTANPDJ DMDYHXE MN Carbonic anhydrase II (CA-II) DMDYHXE MT DTT DMDYHXE MA Inhibitor DMDYHXE RN Carbonic anhydrase inhibitors. Aromatic/heterocyclic sulfonamides incorporating phenacetyl, pyridylacetyl and thienylacetyl tails act as potent inh... Bioorg Med Chem. 2009 Jul 15;17(14):4894-9. DMDYHXE RU https://pubmed.ncbi.nlm.nih.gov/19539481 DMT9RAC DI DMT9RAC DMT9RAC DN 4-(2-Propynylthio)pyridine-3-sulfonamide DMT9RAC MI TTHQPL7 DMT9RAC MN Carbonic anhydrase I (CA-I) DMT9RAC MT DTT DMT9RAC MA Inhibitor DMT9RAC RN Carbonic anhydrase inhibitors: synthesis and inhibition of the human cytosolic isozymes I and II and transmembrane isozymes IX, XII (cancer-associa... Eur J Med Chem. 2010 Jun;45(6):2396-404. DMT9RAC RU https://pubmed.ncbi.nlm.nih.gov/20202722 DMT9RAC DI DMT9RAC DMT9RAC DN 4-(2-Propynylthio)pyridine-3-sulfonamide DMT9RAC MI TTANPDJ DMT9RAC MN Carbonic anhydrase II (CA-II) DMT9RAC MT DTT DMT9RAC MA Inhibitor DMT9RAC RN Carbonic anhydrase inhibitors: synthesis and inhibition of the human cytosolic isozymes I and II and transmembrane isozymes IX, XII (cancer-associa... Eur J Med Chem. 2010 Jun;45(6):2396-404. DMT9RAC RU https://pubmed.ncbi.nlm.nih.gov/20202722 DMT9RAC DI DMT9RAC DMT9RAC DN 4-(2-Propynylthio)pyridine-3-sulfonamide DMT9RAC MI TT2LVK8 DMT9RAC MN Carbonic anhydrase IX (CA-IX) DMT9RAC MT DTT DMT9RAC MA Inhibitor DMT9RAC RN Carbonic anhydrase inhibitors: synthesis and inhibition of the human cytosolic isozymes I and II and transmembrane isozymes IX, XII (cancer-associa... Eur J Med Chem. 2010 Jun;45(6):2396-404. DMT9RAC RU https://pubmed.ncbi.nlm.nih.gov/20202722 DMT9RAC DI DMT9RAC DMT9RAC DN 4-(2-Propynylthio)pyridine-3-sulfonamide DMT9RAC MI TTSYM0R DMT9RAC MN Carbonic anhydrase XII (CA-XII) DMT9RAC MT DTT DMT9RAC MA Inhibitor DMT9RAC RN Carbonic anhydrase inhibitors: synthesis and inhibition of the human cytosolic isozymes I and II and transmembrane isozymes IX, XII (cancer-associa... Eur J Med Chem. 2010 Jun;45(6):2396-404. DMT9RAC RU https://pubmed.ncbi.nlm.nih.gov/20202722 DMT9RAC DI DMT9RAC DMT9RAC DN 4-(2-Propynylthio)pyridine-3-sulfonamide DMT9RAC MI TTEYTKG DMT9RAC MN Carbonic anhydrase XIV (CA-XIV) DMT9RAC MT DTT DMT9RAC MA Inhibitor DMT9RAC RN Carbonic anhydrase inhibitors: synthesis and inhibition of the human cytosolic isozymes I and II and transmembrane isozymes IX, XII (cancer-associa... Eur J Med Chem. 2010 Jun;45(6):2396-404. DMT9RAC RU https://pubmed.ncbi.nlm.nih.gov/20202722 DM9LKMP DI DM9LKMP DM9LKMP DN 4-(2-Pyridin-2-ylacetamido)benzenesulfonamide DM9LKMP MI TTUNARX DM9LKMP MN Carbonic anhydrase (CA) DM9LKMP MT DTT DM9LKMP MA Inhibitor DM9LKMP RN Carbonic anhydrase inhibitors. Aromatic/heterocyclic sulfonamides incorporating phenacetyl, pyridylacetyl and thienylacetyl tails act as potent inh... Bioorg Med Chem. 2009 Jul 15;17(14):4894-9. DM9LKMP RU https://pubmed.ncbi.nlm.nih.gov/19539481 DM9LKMP DI DM9LKMP DM9LKMP DN 4-(2-Pyridin-2-ylacetamido)benzenesulfonamide DM9LKMP MI TTHQPL7 DM9LKMP MN Carbonic anhydrase I (CA-I) DM9LKMP MT DTT DM9LKMP MA Inhibitor DM9LKMP RN Carbonic anhydrase inhibitors. Aromatic/heterocyclic sulfonamides incorporating phenacetyl, pyridylacetyl and thienylacetyl tails act as potent inh... Bioorg Med Chem. 2009 Jul 15;17(14):4894-9. DM9LKMP RU https://pubmed.ncbi.nlm.nih.gov/19539481 DM9LKMP DI DM9LKMP DM9LKMP DN 4-(2-Pyridin-2-ylacetamido)benzenesulfonamide DM9LKMP MI TTANPDJ DM9LKMP MN Carbonic anhydrase II (CA-II) DM9LKMP MT DTT DM9LKMP MA Inhibitor DM9LKMP RN Carbonic anhydrase inhibitors. Aromatic/heterocyclic sulfonamides incorporating phenacetyl, pyridylacetyl and thienylacetyl tails act as potent inh... Bioorg Med Chem. 2009 Jul 15;17(14):4894-9. DM9LKMP RU https://pubmed.ncbi.nlm.nih.gov/19539481 DMD6AYQ DI DMD6AYQ DMD6AYQ DN 4-(2-Pyridin-4-ylacetamido)benzenesulfonamide DMD6AYQ MI TTUNARX DMD6AYQ MN Carbonic anhydrase (CA) DMD6AYQ MT DTT DMD6AYQ MA Inhibitor DMD6AYQ RN Carbonic anhydrase inhibitors. Aromatic/heterocyclic sulfonamides incorporating phenacetyl, pyridylacetyl and thienylacetyl tails act as potent inh... Bioorg Med Chem. 2009 Jul 15;17(14):4894-9. DMD6AYQ RU https://pubmed.ncbi.nlm.nih.gov/19539481 DMD6AYQ DI DMD6AYQ DMD6AYQ DN 4-(2-Pyridin-4-ylacetamido)benzenesulfonamide DMD6AYQ MI TTHQPL7 DMD6AYQ MN Carbonic anhydrase I (CA-I) DMD6AYQ MT DTT DMD6AYQ MA Inhibitor DMD6AYQ RN Carbonic anhydrase inhibitors. Aromatic/heterocyclic sulfonamides incorporating phenacetyl, pyridylacetyl and thienylacetyl tails act as potent inh... Bioorg Med Chem. 2009 Jul 15;17(14):4894-9. DMD6AYQ RU https://pubmed.ncbi.nlm.nih.gov/19539481 DMD6AYQ DI DMD6AYQ DMD6AYQ DN 4-(2-Pyridin-4-ylacetamido)benzenesulfonamide DMD6AYQ MI TTANPDJ DMD6AYQ MN Carbonic anhydrase II (CA-II) DMD6AYQ MT DTT DMD6AYQ MA Inhibitor DMD6AYQ RN Carbonic anhydrase inhibitors. Aromatic/heterocyclic sulfonamides incorporating phenacetyl, pyridylacetyl and thienylacetyl tails act as potent inh... Bioorg Med Chem. 2009 Jul 15;17(14):4894-9. DMD6AYQ RU https://pubmed.ncbi.nlm.nih.gov/19539481 DMOSDAN DI DMOSDAN DMOSDAN DN 4-(2-pyrrolidin-1-yl-pentanoyl)benzonitrile DMOSDAN MI TTVBI8W DMOSDAN MN Dopamine transporter (DAT) DMOSDAN MT DTT DMOSDAN MA Inhibitor DMOSDAN RN 1-(4-Methylphenyl)-2-pyrrolidin-1-yl-pentan-1-one (Pyrovalerone) analogues: a promising class of monoamine uptake inhibitors. J Med Chem. 2006 Feb 23;49(4):1420-32. DMOSDAN RU https://pubmed.ncbi.nlm.nih.gov/16480278 DMX681M DI DMX681M DMX681M DN 4-(2-Thienyl)-1-(4-Methylbenzyl)-1h-Imidazole DMX681M MI TTVTX4N DMX681M MN Bacterial Fatty acid synthetase I (Bact inhA) DMX681M MT DTT DMX681M MA Inhibitor DMX681M RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMX681M RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMX681M DI DMX681M DMX681M DN 4-(2-Thienyl)-1-(4-Methylbenzyl)-1h-Imidazole DMX681M MI TTNX2CS DMX681M MN Plasmodium Enoyl-ACP reductase (Malaria fabI) DMX681M MT DTT DMX681M MA Inhibitor DMX681M RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMX681M RU https://pubmed.ncbi.nlm.nih.gov/17139284 DM4YWQN DI DM4YWQN DM4YWQN DN 4-(2-thienyl)benzene-1,2-diamine DM4YWQN MI TTQ6VDM DM4YWQN MN Voltage-gated potassium channel Kv11.1 (KCNH2) DM4YWQN MT DTT DM4YWQN MA Inhibitor DM4YWQN RN Parallel medicinal chemistry approaches to selective HDAC1/HDAC2 inhibitor (SHI-1:2) optimization. Bioorg Med Chem Lett. 2009 Feb 15;19(4):1168-72. DM4YWQN RU https://pubmed.ncbi.nlm.nih.gov/19138845 DMR3T2D DI DMR3T2D DMR3T2D DN 4-(3-(4-hydroxyphenyl)-1H-indol-2-yl)phenol DMR3T2D MI TTZAYWL DMR3T2D MN Estrogen receptor (ESR) DMR3T2D MT DTT DMR3T2D MA Inhibitor DMR3T2D RN Estrogen receptor beta selective ligands: discovery and SAR of novel heterocyclic ligands. Bioorg Med Chem Lett. 2005 Dec 15;15(24):5562-6. DMR3T2D RU https://pubmed.ncbi.nlm.nih.gov/16219463 DMR3T2D DI DMR3T2D DMR3T2D DN 4-(3-(4-hydroxyphenyl)-1H-indol-2-yl)phenol DMR3T2D MI TTOM3J0 DMR3T2D MN Estrogen receptor beta (ESR2) DMR3T2D MT DTT DMR3T2D MA Inhibitor DMR3T2D RN Estrogen receptor beta selective ligands: discovery and SAR of novel heterocyclic ligands. Bioorg Med Chem Lett. 2005 Dec 15;15(24):5562-6. DMR3T2D RU https://pubmed.ncbi.nlm.nih.gov/16219463 DMX5V9T DI DMX5V9T DMX5V9T DN 4-(3-(Dimethylamino)propanoyl)-N-hexylbenzamide DMX5V9T MI TTGER3L DMX5V9T MN Thyroid hormone receptor beta (THRB) DMX5V9T MT DTT DMX5V9T MA Inhibitor DMX5V9T RN Improvement of pharmacological properties of irreversible thyroid receptor coactivator binding inhibitors. J Med Chem. 2009 Jul 9;52(13):3892-901. DMX5V9T RU https://pubmed.ncbi.nlm.nih.gov/19469546 DMNUWK2 DI DMNUWK2 DMNUWK2 DN 4-(3,4,5-Trimethoxyphenethyl)aniline DMNUWK2 MI TTSZLWK DMNUWK2 MN Aromatase (CYP19A1) DMNUWK2 MT DTT DMNUWK2 MA Inhibitor DMNUWK2 RN Design, synthesis, and biological evaluation of resveratrol analogues as aromatase and quinone reductase 2 inhibitors for chemoprevention of cancer. Bioorg Med Chem. 2010 Jul 15;18(14):5352-66. DMNUWK2 RU https://pubmed.ncbi.nlm.nih.gov/20558073 DMBEA23 DI DMBEA23 DMBEA23 DN 4-(3,4-dichlorobenzylthio)-2-aminobutanoic acid DMBEA23 MI TTFK1JQ DMBEA23 MN Voltage-gated calcium channel alpha-2/delta-1 (CACNA2D1) DMBEA23 MT DTT DMBEA23 MA Inhibitor DMBEA23 RN Structure-activity relationships of alpha-amino acid ligands for the alpha2delta subunit of voltage-gated calcium channels. Bioorg Med Chem Lett. 2006 Mar 1;16(5):1138-41. DMBEA23 RU https://pubmed.ncbi.nlm.nih.gov/16380257 DMIZXYM DI DMIZXYM DMIZXYM DN 4-(3,4-Diethoxy-benzylamino)-benzamidine DMIZXYM MI TT2WR1T DMIZXYM MN Cationic trypsinogen (PRSS1) DMIZXYM MT DTT DMIZXYM MA Inhibitor DMIZXYM RN Design of selective phenylglycine amide tissue factor/factor VIIa inhibitors. Bioorg Med Chem Lett. 2005 Feb 1;15(3):817-22. DMIZXYM RU https://pubmed.ncbi.nlm.nih.gov/15664864 DMIZXYM DI DMIZXYM DMIZXYM DN 4-(3,4-Diethoxy-benzylamino)-benzamidine DMIZXYM MI TT6L509 DMIZXYM MN Coagulation factor IIa (F2) DMIZXYM MT DTT DMIZXYM MA Inhibitor DMIZXYM RN Design of selective phenylglycine amide tissue factor/factor VIIa inhibitors. Bioorg Med Chem Lett. 2005 Feb 1;15(3):817-22. DMIZXYM RU https://pubmed.ncbi.nlm.nih.gov/15664864 DMIZXYM DI DMIZXYM DMIZXYM DN 4-(3,4-Diethoxy-benzylamino)-benzamidine DMIZXYM MI TTF0EGX DMIZXYM MN Coagulation factor VII (F7) DMIZXYM MT DTT DMIZXYM MA Inhibitor DMIZXYM RN Design of selective phenylglycine amide tissue factor/factor VIIa inhibitors. Bioorg Med Chem Lett. 2005 Feb 1;15(3):817-22. DMIZXYM RU https://pubmed.ncbi.nlm.nih.gov/15664864 DMCOJIL DI DMCOJIL DMCOJIL DN 4-(3,4-Dihydro-1H-isoquinolin-2-yl)-quinoline DMCOJIL MI TTNGILX DMCOJIL MN Adrenergic receptor alpha-1A (ADRA1A) DMCOJIL MT DTT DMCOJIL MA Inhibitor DMCOJIL RN 4-(3,4-dihydro-1H-isoquinolin-2yl)-pyridines and 4-(3,4-dihydro-1H-isoquinolin-2-yl)-quinolines as potent NR1/2B subtype selective NMDA receptor an... Bioorg Med Chem Lett. 2003 May 19;13(10):1759-62. DMCOJIL RU https://pubmed.ncbi.nlm.nih.gov/12729659 DMCOJIL DI DMCOJIL DMCOJIL DN 4-(3,4-Dihydro-1H-isoquinolin-2-yl)-quinoline DMCOJIL MI TTBRKXS DMCOJIL MN Adrenergic receptor alpha-1B (ADRA1B) DMCOJIL MT DTT DMCOJIL MA Inhibitor DMCOJIL RN 4-(3,4-dihydro-1H-isoquinolin-2yl)-pyridines and 4-(3,4-dihydro-1H-isoquinolin-2-yl)-quinolines as potent NR1/2B subtype selective NMDA receptor an... Bioorg Med Chem Lett. 2003 May 19;13(10):1759-62. DMCOJIL RU https://pubmed.ncbi.nlm.nih.gov/12729659 DMCOJIL DI DMCOJIL DMCOJIL DN 4-(3,4-Dihydro-1H-isoquinolin-2-yl)-quinoline DMCOJIL MI TT34BHT DMCOJIL MN Adrenergic receptor alpha-1D (ADRA1D) DMCOJIL MT DTT DMCOJIL MA Inhibitor DMCOJIL RN 4-(3,4-dihydro-1H-isoquinolin-2yl)-pyridines and 4-(3,4-dihydro-1H-isoquinolin-2-yl)-quinolines as potent NR1/2B subtype selective NMDA receptor an... Bioorg Med Chem Lett. 2003 May 19;13(10):1759-62. DMCOJIL RU https://pubmed.ncbi.nlm.nih.gov/12729659 DMCOJIL DI DMCOJIL DMCOJIL DN 4-(3,4-Dihydro-1H-isoquinolin-2-yl)-quinoline DMCOJIL MI TTLD29N DMCOJIL MN Glutamate receptor ionotropic NMDA 1 (NMDAR1) DMCOJIL MT DTT DMCOJIL MA Inhibitor DMCOJIL RN 4-(3,4-dihydro-1H-isoquinolin-2yl)-pyridines and 4-(3,4-dihydro-1H-isoquinolin-2-yl)-quinolines as potent NR1/2B subtype selective NMDA receptor an... Bioorg Med Chem Lett. 2003 May 19;13(10):1759-62. DMCOJIL RU https://pubmed.ncbi.nlm.nih.gov/12729659 DMCOJIL DI DMCOJIL DMCOJIL DN 4-(3,4-Dihydro-1H-isoquinolin-2-yl)-quinoline DMCOJIL MI TTN9D8E DMCOJIL MN Glutamate receptor ionotropic NMDA 2B (NMDAR2B) DMCOJIL MT DTT DMCOJIL MA Inhibitor DMCOJIL RN 4-(3,4-dihydro-1H-isoquinolin-2yl)-pyridines and 4-(3,4-dihydro-1H-isoquinolin-2-yl)-quinolines as potent NR1/2B subtype selective NMDA receptor an... Bioorg Med Chem Lett. 2003 May 19;13(10):1759-62. DMCOJIL RU https://pubmed.ncbi.nlm.nih.gov/12729659 DMBI7MS DI DMBI7MS DMBI7MS DN 4-(3,4-Dimethoxyphenethyl)aniline DMBI7MS MI TTSZLWK DMBI7MS MN Aromatase (CYP19A1) DMBI7MS MT DTT DMBI7MS MA Inhibitor DMBI7MS RN Design, synthesis, and biological evaluation of resveratrol analogues as aromatase and quinone reductase 2 inhibitors for chemoprevention of cancer. Bioorg Med Chem. 2010 Jul 15;18(14):5352-66. DMBI7MS RU https://pubmed.ncbi.nlm.nih.gov/20558073 DMW1H6C DI DMW1H6C DMW1H6C DN 4-(3,4-Dimethoxy-phenoxy)-6,7-dimethoxy-quinoline DMW1H6C MI TT8FYO9 DMW1H6C MN Platelet-derived growth factor receptor alpha (PDGFRA) DMW1H6C MT DTT DMW1H6C MA Inhibitor DMW1H6C RN A novel series of 4-phenoxyquinolines: potent and highly selective inhibitors of PDGF receptor autophosphorylation, Bioorg. Med. Chem. Lett. 7(23):2935-2940 (1997). DMW1H6C RU http://www.sciencedirect.com/science/article/pii/S0960894X97101172 DMW1H6C DI DMW1H6C DMW1H6C DN 4-(3,4-Dimethoxy-phenoxy)-6,7-dimethoxy-quinoline DMW1H6C MI TTI7421 DMW1H6C MN Platelet-derived growth factor receptor beta (PDGFRB) DMW1H6C MT DTT DMW1H6C MA Inhibitor DMW1H6C RN A novel series of 4-phenoxyquinolines: potent and highly selective inhibitors of PDGF receptor autophosphorylation, Bioorg. Med. Chem. Lett. 7(23):2935-2940 (1997). DMW1H6C RU http://www.sciencedirect.com/science/article/pii/S0960894X97101172 DM5ZTXO DI DM5ZTXO DM5ZTXO DN 4-(3,4-dimethylbenzylthio)-2-aminobutanoic acid DM5ZTXO MI TTFK1JQ DM5ZTXO MN Voltage-gated calcium channel alpha-2/delta-1 (CACNA2D1) DM5ZTXO MT DTT DM5ZTXO MA Inhibitor DM5ZTXO RN Structure-activity relationships of alpha-amino acid ligands for the alpha2delta subunit of voltage-gated calcium channels. Bioorg Med Chem Lett. 2006 Mar 1;16(5):1138-41. DM5ZTXO RU https://pubmed.ncbi.nlm.nih.gov/16380257 DMM3F9K DI DMM3F9K DMM3F9K DN 4-(3,5-dichlorobenzylthio)-2-aminobutanoic acid DMM3F9K MI TTFK1JQ DMM3F9K MN Voltage-gated calcium channel alpha-2/delta-1 (CACNA2D1) DMM3F9K MT DTT DMM3F9K MA Inhibitor DMM3F9K RN Structure-activity relationships of alpha-amino acid ligands for the alpha2delta subunit of voltage-gated calcium channels. Bioorg Med Chem Lett. 2006 Mar 1;16(5):1138-41. DMM3F9K RU https://pubmed.ncbi.nlm.nih.gov/16380257 DM48Z5Y DI DM48Z5Y DM48Z5Y DN 4-(3,5-difluorophenylethynyl)-2-methylthiazole DM48Z5Y MI TTHS256 DM48Z5Y MN Metabotropic glutamate receptor 5 (mGluR5) DM48Z5Y MT DTT DM48Z5Y MA Inhibitor DM48Z5Y RN Synthesis and structure-activity relationships of 3-[(2-methyl-1,3-thiazol-4-yl)ethynyl]pyridine analogues as potent, noncompetitive metabotropic g... J Med Chem. 2006 Feb 9;49(3):1080-100. DM48Z5Y RU https://pubmed.ncbi.nlm.nih.gov/16451073 DM4FC9O DI DM4FC9O DM4FC9O DN 4-(3,5-Dimethoxyphenethyl)benzenamine DM4FC9O MI TTSZLWK DM4FC9O MN Aromatase (CYP19A1) DM4FC9O MT DTT DM4FC9O MA Inhibitor DM4FC9O RN Design, synthesis, and biological evaluation of resveratrol analogues as aromatase and quinone reductase 2 inhibitors for chemoprevention of cancer. Bioorg Med Chem. 2010 Jul 15;18(14):5352-66. DM4FC9O RU https://pubmed.ncbi.nlm.nih.gov/20558073 DM5279R DI DM5279R DM5279R DN 4-(3,5-Dimethoxy-phenoxy)-6,7-dimethoxy-quinoline DM5279R MI TTI7421 DM5279R MN Platelet-derived growth factor receptor beta (PDGFRB) DM5279R MT DTT DM5279R MA Inhibitor DM5279R RN A novel series of 4-phenoxyquinolines: potent and highly selective inhibitors of PDGF receptor autophosphorylation, Bioorg. Med. Chem. Lett. 7(23):2935-2940 (1997). DM5279R RU http://www.sciencedirect.com/science/article/pii/S0960894X97101172 DM9MIQB DI DM9MIQB DM9MIQB DN 4-(3,5-dimethylbenzylthio)-2-aminobutanoic acid DM9MIQB MI TTFK1JQ DM9MIQB MN Voltage-gated calcium channel alpha-2/delta-1 (CACNA2D1) DM9MIQB MT DTT DM9MIQB MA Inhibitor DM9MIQB RN Structure-activity relationships of alpha-amino acid ligands for the alpha2delta subunit of voltage-gated calcium channels. Bioorg Med Chem Lett. 2006 Mar 1;16(5):1138-41. DM9MIQB RU https://pubmed.ncbi.nlm.nih.gov/16380257 DMKUAEY DI DMKUAEY DMKUAEY DN 4-(3-Adamantan-1-yl-ureido)-benzoic acid DMKUAEY MI TT7WVHI DMKUAEY MN Soluble epoxide hydrolase (EPHX2) DMKUAEY MT DTT DMKUAEY MA Inhibitor DMKUAEY RN Salicylate-urea-based soluble epoxide hydrolase inhibitors with high metabolic and chemical stabilities. Bioorg Med Chem Lett. 2009 Mar 15;19(6):1784-9. DMKUAEY RU https://pubmed.ncbi.nlm.nih.gov/19216074 DMLVZ6O DI DMLVZ6O DMLVZ6O DN 4-(3-benzenesulfonamidophenyl)piperazine DMLVZ6O MI TTJS8PY DMLVZ6O MN 5-HT 6 receptor (HTR6) DMLVZ6O MT DTT DMLVZ6O MA Inhibitor DMLVZ6O RN Binding of sulfonyl-containing arylalkylamines at human 5-HT6 serotonin receptors. J Med Chem. 2006 Aug 24;49(17):5217-25. DMLVZ6O RU https://pubmed.ncbi.nlm.nih.gov/16913710 DMG4X13 DI DMG4X13 DMG4X13 DN 4-(3-benzenesulfonylphenyl)piperazine DMG4X13 MI TTJS8PY DMG4X13 MN 5-HT 6 receptor (HTR6) DMG4X13 MT DTT DMG4X13 MA Inhibitor DMG4X13 RN Binding of sulfonyl-containing arylalkylamines at human 5-HT6 serotonin receptors. J Med Chem. 2006 Aug 24;49(17):5217-25. DMG4X13 RU https://pubmed.ncbi.nlm.nih.gov/16913710 DMT0EK8 DI DMT0EK8 DMT0EK8 DN 4-(3-Benzoyl-1H-pyrrol-1-yl)butanoic acid DMT0EK8 MI TTFBNVI DMT0EK8 MN Aldose reductase (AKR1B1) DMT0EK8 MT DTT DMT0EK8 MA Inhibitor DMT0EK8 RN Design and synthesis of novel series of pyrrole based chemotypes and their evaluation as selective aldose reductase inhibitors. A case of bioisoste... Bioorg Med Chem. 2010 Mar 15;18(6):2107-2114. DMT0EK8 RU https://pubmed.ncbi.nlm.nih.gov/20189816 DML3VB7 DI DML3VB7 DML3VB7 DN 4-(3-bromobenzylthio)-2-aminobutanoic acid DML3VB7 MI TTFK1JQ DML3VB7 MN Voltage-gated calcium channel alpha-2/delta-1 (CACNA2D1) DML3VB7 MT DTT DML3VB7 MA Inhibitor DML3VB7 RN Structure-activity relationships of alpha-amino acid ligands for the alpha2delta subunit of voltage-gated calcium channels. Bioorg Med Chem Lett. 2006 Mar 1;16(5):1138-41. DML3VB7 RU https://pubmed.ncbi.nlm.nih.gov/16380257 DMNBLQ8 DI DMNBLQ8 DMNBLQ8 DN 4-(3-Bromo-phenoxy)-6,7-dimethoxy-quinazoline DMNBLQ8 MI TTGKNB4 DMNBLQ8 MN Epidermal growth factor receptor (EGFR) DMNBLQ8 MT DTT DMNBLQ8 MA Inhibitor DMNBLQ8 RN A novel series of 4-phenoxyquinolines: potent and highly selective inhibitors of PDGF receptor autophosphorylation, Bioorg. Med. Chem. Lett. 7(23):2935-2940 (1997). DMNBLQ8 RU http://www.sciencedirect.com/science/article/pii/S0960894X97101172 DMNBLQ8 DI DMNBLQ8 DMNBLQ8 DN 4-(3-Bromo-phenoxy)-6,7-dimethoxy-quinazoline DMNBLQ8 MI TTI7421 DMNBLQ8 MN Platelet-derived growth factor receptor beta (PDGFRB) DMNBLQ8 MT DTT DMNBLQ8 MA Inhibitor DMNBLQ8 RN A novel series of 4-phenoxyquinolines: potent and highly selective inhibitors of PDGF receptor autophosphorylation, Bioorg. Med. Chem. Lett. 7(23):2935-2940 (1997). DMNBLQ8 RU http://www.sciencedirect.com/science/article/pii/S0960894X97101172 DMK6JV7 DI DMK6JV7 DMK6JV7 DN 4-(3-Bromo-phenoxy)-6,7-dimethoxy-quinoline DMK6JV7 MI TTGKNB4 DMK6JV7 MN Epidermal growth factor receptor (EGFR) DMK6JV7 MT DTT DMK6JV7 MA Inhibitor DMK6JV7 RN A novel series of 4-phenoxyquinolines: potent and highly selective inhibitors of PDGF receptor autophosphorylation, Bioorg. Med. Chem. Lett. 7(23):2935-2940 (1997). DMK6JV7 RU http://www.sciencedirect.com/science/article/pii/S0960894X97101172 DMK6JV7 DI DMK6JV7 DMK6JV7 DN 4-(3-Bromo-phenoxy)-6,7-dimethoxy-quinoline DMK6JV7 MI TTI7421 DMK6JV7 MN Platelet-derived growth factor receptor beta (PDGFRB) DMK6JV7 MT DTT DMK6JV7 MA Inhibitor DMK6JV7 RN A novel series of 4-phenoxyquinolines: potent and highly selective inhibitors of PDGF receptor autophosphorylation, Bioorg. Med. Chem. Lett. 7(23):2935-2940 (1997). DMK6JV7 RU http://www.sciencedirect.com/science/article/pii/S0960894X97101172 DM3LGOT DI DM3LGOT DM3LGOT DN 4-(3-bromophenoxy)-6-chloroquinazoline DM3LGOT MI TTHS256 DM3LGOT MN Metabotropic glutamate receptor 5 (mGluR5) DM3LGOT MT DTT DM3LGOT MA Inhibitor DM3LGOT RN Discovery and SAR of 6-substituted-4-anilinoquinazolines as non-competitive antagonists of mGlu5. Bioorg Med Chem Lett. 2009 Dec 1;19(23):6623-6. DM3LGOT RU https://pubmed.ncbi.nlm.nih.gov/19854049 DM1Q5KV DI DM1Q5KV DM1Q5KV DN 4-(3-Bromo-phenylamino)-quinazoline-6,7-diol DM1Q5KV MI TTGKNB4 DM1Q5KV MN Epidermal growth factor receptor (EGFR) DM1Q5KV MT DTT DM1Q5KV MA Inhibitor DM1Q5KV RN Tyrosine kinase inhibitors. 9. Synthesis and evaluation of fused tricyclic quinazoline analogues as ATP site inhibitors of the tyrosine kinase acti... J Med Chem. 1996 Feb 16;39(4):918-28. DM1Q5KV RU https://pubmed.ncbi.nlm.nih.gov/8632415 DMQBHF2 DI DMQBHF2 DMQBHF2 DN 4-(3-bromophenylthio)-2-(pyridin-2-yl)pyrimidine DMQBHF2 MI TTHS256 DMQBHF2 MN Metabotropic glutamate receptor 5 (mGluR5) DMQBHF2 MT DTT DMQBHF2 MA Inhibitor DMQBHF2 RN Structure-activity relationship of thiopyrimidines as mGluR5 antagonists. Bioorg Med Chem Lett. 2006 May 1;16(9):2467-9. DMQBHF2 RU https://pubmed.ncbi.nlm.nih.gov/16481165 DML5NF6 DI DML5NF6 DML5NF6 DN 4-(3-bromopyrazolo[1,5-a]pyrimidin-6-yl)phenol DML5NF6 MI TTLAFZV DML5NF6 MN AMP-activated protein kinase (AMPK) DML5NF6 MT DTT DML5NF6 MA Inhibitor DML5NF6 RN The rational design of a novel potent analogue of the 5'-AMP-activated protein kinase inhibitor compound C with improved selectivity and cellular a... Bioorg Med Chem Lett. 2010 Nov 15;20(22):6394-9. DML5NF6 RU https://pubmed.ncbi.nlm.nih.gov/20932747 DMQVXMZ DI DMQVXMZ DMQVXMZ DN 4-(3-chlorobenzylthio)-2-aminobutanoic acid DMQVXMZ MI TTFK1JQ DMQVXMZ MN Voltage-gated calcium channel alpha-2/delta-1 (CACNA2D1) DMQVXMZ MT DTT DMQVXMZ MA Inhibitor DMQVXMZ RN Structure-activity relationships of alpha-amino acid ligands for the alpha2delta subunit of voltage-gated calcium channels. Bioorg Med Chem Lett. 2006 Mar 1;16(5):1138-41. DMQVXMZ RU https://pubmed.ncbi.nlm.nih.gov/16380257 DMDS2LZ DI DMDS2LZ DMDS2LZ DN 4-(3-Chloro-phenoxy)-6,7-dimethoxy-quinazoline DMDS2LZ MI TT860QF DMDS2LZ MN LCK tyrosine protein kinase (LCK) DMDS2LZ MT DTT DMDS2LZ MA Inhibitor DMDS2LZ RN he preparation and sar of 4-(anilino), 4-(phenoxy), and 4-(thiophenoxy)-quinazolines: Inhibitors of p56lck and EGF-R tyrosine kinase activity, Bioorg. Med. Chem. Lett. 7(4):417-420 (1997). DMDS2LZ RU http://www.sciencedirect.com/science/article/pii/S0960894X97000346 DMDTFKL DI DMDTFKL DMDTFKL DN 4-(3-chlorophenylethynyl)-2-methylthiazole DMDTFKL MI TTHS256 DMDTFKL MN Metabotropic glutamate receptor 5 (mGluR5) DMDTFKL MT DTT DMDTFKL MA Inhibitor DMDTFKL RN Synthesis and structure-activity relationships of 3-[(2-methyl-1,3-thiazol-4-yl)ethynyl]pyridine analogues as potent, noncompetitive metabotropic g... J Med Chem. 2006 Feb 9;49(3):1080-100. DMDTFKL RU https://pubmed.ncbi.nlm.nih.gov/16451073 DMJH2OE DI DMJH2OE DMJH2OE DN 4-(3-chlorophenylthio)-2-(pyridin-2-yl)pyrimidine DMJH2OE MI TTHS256 DMJH2OE MN Metabotropic glutamate receptor 5 (mGluR5) DMJH2OE MT DTT DMJH2OE MA Inhibitor DMJH2OE RN Structure-activity relationship of thiopyrimidines as mGluR5 antagonists. Bioorg Med Chem Lett. 2006 May 1;16(9):2467-9. DMJH2OE RU https://pubmed.ncbi.nlm.nih.gov/16481165 DMSUB8D DI DMSUB8D DMSUB8D DN 4-(3-cyanobenzylthio)-2-aminobutanoic acid DMSUB8D MI TTFK1JQ DMSUB8D MN Voltage-gated calcium channel alpha-2/delta-1 (CACNA2D1) DMSUB8D MT DTT DMSUB8D MA Inhibitor DMSUB8D RN Structure-activity relationships of alpha-amino acid ligands for the alpha2delta subunit of voltage-gated calcium channels. Bioorg Med Chem Lett. 2006 Mar 1;16(5):1138-41. DMSUB8D RU https://pubmed.ncbi.nlm.nih.gov/16380257 DMXFLMK DI DMXFLMK DMXFLMK DN 4-(3-cyclohexylureido)butanoic acid DMXFLMK MI TT7WVHI DMXFLMK MN Soluble epoxide hydrolase (EPHX2) DMXFLMK MT DTT DMXFLMK MA Inhibitor DMXFLMK RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DMXFLMK RU https://pubmed.ncbi.nlm.nih.gov/10592235 DMOQE5W DI DMOQE5W DMOQE5W DN 4-(3-Ethoxy-phenoxy)-6,7-dimethoxy-quinoline DMOQE5W MI TTI7421 DMOQE5W MN Platelet-derived growth factor receptor beta (PDGFRB) DMOQE5W MT DTT DMOQE5W MA Inhibitor DMOQE5W RN A novel series of 4-phenoxyquinolines: potent and highly selective inhibitors of PDGF receptor autophosphorylation, Bioorg. Med. Chem. Lett. 7(23):2935-2940 (1997). DMOQE5W RU http://www.sciencedirect.com/science/article/pii/S0960894X97101172 DMFM9SH DI DMFM9SH DMFM9SH DN 4-(3-Ethyl-phenoxy)-6,7-dimethoxy-quinoline DMFM9SH MI TTI7421 DMFM9SH MN Platelet-derived growth factor receptor beta (PDGFRB) DMFM9SH MT DTT DMFM9SH MA Inhibitor DMFM9SH RN A novel series of 4-phenoxyquinolines: potent and highly selective inhibitors of PDGF receptor autophosphorylation, Bioorg. Med. Chem. Lett. 7(23):2935-2940 (1997). DMFM9SH RU http://www.sciencedirect.com/science/article/pii/S0960894X97101172 DM1C3NZ DI DM1C3NZ DM1C3NZ DN 4-(3-fluoro-2-phenoxyphenyl)piperidine DM1C3NZ MI TTSQIFT DM1C3NZ MN 5-HT 1A receptor (HTR1A) DM1C3NZ MT DTT DM1C3NZ MA Inhibitor DM1C3NZ RN Discovery and pharmacological characterization of aryl piperazine and piperidine ethers as dual acting norepinephrine reuptake inhibitors and 5-HT1... Bioorg Med Chem Lett. 2009 Dec 1;19(23):6604-7. DM1C3NZ RU https://pubmed.ncbi.nlm.nih.gov/19854053 DM1C3NZ DI DM1C3NZ DM1C3NZ DN 4-(3-fluoro-2-phenoxyphenyl)piperidine DM1C3NZ MI TTVBI8W DM1C3NZ MN Dopamine transporter (DAT) DM1C3NZ MT DTT DM1C3NZ MA Inhibitor DM1C3NZ RN Discovery and pharmacological characterization of aryl piperazine and piperidine ethers as dual acting norepinephrine reuptake inhibitors and 5-HT1... Bioorg Med Chem Lett. 2009 Dec 1;19(23):6604-7. DM1C3NZ RU https://pubmed.ncbi.nlm.nih.gov/19854053 DM1C3NZ DI DM1C3NZ DM1C3NZ DN 4-(3-fluoro-2-phenoxyphenyl)piperidine DM1C3NZ MI TTAWNKZ DM1C3NZ MN Norepinephrine transporter (NET) DM1C3NZ MT DTT DM1C3NZ MA Inhibitor DM1C3NZ RN Discovery and pharmacological characterization of aryl piperazine and piperidine ethers as dual acting norepinephrine reuptake inhibitors and 5-HT1... Bioorg Med Chem Lett. 2009 Dec 1;19(23):6604-7. DM1C3NZ RU https://pubmed.ncbi.nlm.nih.gov/19854053 DM1C3NZ DI DM1C3NZ DM1C3NZ DN 4-(3-fluoro-2-phenoxyphenyl)piperidine DM1C3NZ MI TT3ROYC DM1C3NZ MN Serotonin transporter (SERT) DM1C3NZ MT DTT DM1C3NZ MA Inhibitor DM1C3NZ RN Discovery and pharmacological characterization of aryl piperazine and piperidine ethers as dual acting norepinephrine reuptake inhibitors and 5-HT1... Bioorg Med Chem Lett. 2009 Dec 1;19(23):6604-7. DM1C3NZ RU https://pubmed.ncbi.nlm.nih.gov/19854053 DMXLC94 DI DMXLC94 DMXLC94 DN 4-(3-fluorobenzylthio)-2-aminobutanoic acid DMXLC94 MI TTFK1JQ DMXLC94 MN Voltage-gated calcium channel alpha-2/delta-1 (CACNA2D1) DMXLC94 MT DTT DMXLC94 MA Inhibitor DMXLC94 RN Structure-activity relationships of alpha-amino acid ligands for the alpha2delta subunit of voltage-gated calcium channels. Bioorg Med Chem Lett. 2006 Mar 1;16(5):1138-41. DMXLC94 RU https://pubmed.ncbi.nlm.nih.gov/16380257 DMER3D9 DI DMER3D9 DMER3D9 DN 4-(3-Fluoro-phenoxy)-6,7-dimethoxy-quinoline DMER3D9 MI TTI7421 DMER3D9 MN Platelet-derived growth factor receptor beta (PDGFRB) DMER3D9 MT DTT DMER3D9 MA Inhibitor DMER3D9 RN A novel series of 4-phenoxyquinolines: potent and highly selective inhibitors of PDGF receptor autophosphorylation, Bioorg. Med. Chem. Lett. 7(23):2935-2940 (1997). DMER3D9 RU http://www.sciencedirect.com/science/article/pii/S0960894X97101172 DM6RV9L DI DM6RV9L DM6RV9L DN 4-(3-fluorophenylethynyl)-2-thiazolylamine DM6RV9L MI TTHS256 DM6RV9L MN Metabotropic glutamate receptor 5 (mGluR5) DM6RV9L MT DTT DM6RV9L MA Inhibitor DM6RV9L RN Synthesis and structure-activity relationships of 3-[(2-methyl-1,3-thiazol-4-yl)ethynyl]pyridine analogues as potent, noncompetitive metabotropic g... J Med Chem. 2006 Feb 9;49(3):1080-100. DM6RV9L RU https://pubmed.ncbi.nlm.nih.gov/16451073 DMZ1TNM DI DMZ1TNM DMZ1TNM DN 4-(3'-furyl)-aniline DMZ1TNM MI TTAWNKZ DMZ1TNM MN Norepinephrine transporter (NET) DMZ1TNM MT DTT DMZ1TNM MA Inhibitor DMZ1TNM RN Designing active template molecules by combining computational de novo design and human chemist's expertise. J Med Chem. 2007 Apr 19;50(8):1925-32. DMZ1TNM RU https://pubmed.ncbi.nlm.nih.gov/17367122 DMC5GAW DI DMC5GAW DMC5GAW DN 4-(3-hexylureido)-N-phenylbenzenesulfonamide DMC5GAW MI TTWDC17 DMC5GAW MN Growth hormone secretagogue receptor 1 (GHSR) DMC5GAW MT DTT DMC5GAW MA Inhibitor DMC5GAW RN Discovery and optimization of novel 4-[(aminocarbonyl)amino]-N-[4-(2-aminoethyl)phenyl]benzenesulfonamide ghrelin receptor antagonists. Bioorg Med Chem Lett. 2009 Nov 1;19(21):6237-40. DMC5GAW RU https://pubmed.ncbi.nlm.nih.gov/19767208 DM3QJVT DI DM3QJVT DM3QJVT DN 4-(3H-Inden-1-ylmethyl)-phenylamine DM3QJVT MI TTJS8PY DM3QJVT MN 5-HT 6 receptor (HTR6) DM3QJVT MT DTT DM3QJVT MA Inhibitor DM3QJVT RN Binding of isotryptamines and indenes at h5-HT6 serotonin receptors. Bioorg Med Chem Lett. 2005 Apr 15;15(8):1987-91. DM3QJVT RU https://pubmed.ncbi.nlm.nih.gov/15808453 DMM8AY5 DI DMM8AY5 DMM8AY5 DN 4-(3H-indol-4-ylamino)-5-styrylnicotinonitrile DMM8AY5 MI TT1MS7X DMM8AY5 MN PKC-theta messenger RNA (PRKCQ mRNA) DMM8AY5 MT DTT DMM8AY5 MA Inhibitor DMM8AY5 RN First generation 5-vinyl-3-pyridinecarbonitrile PKCtheta inhibitors. Bioorg Med Chem Lett. 2009 Oct 15;19(20):5829-32. DMM8AY5 RU https://pubmed.ncbi.nlm.nih.gov/19762237 DMY2OVL DI DMY2OVL DMY2OVL DN 4-(3-hydroxy-benzylideneamino)-benzenesulfonamide DMY2OVL MI TTVKILB DMY2OVL MN Prostaglandin G/H synthase 2 (COX-2) DMY2OVL MT DTT DMY2OVL MA Inhibitor DMY2OVL RN Selective COX-2 inhibitors. Part 2: synthesis and biological evaluation of 4-benzylideneamino- and 4-phenyliminomethyl-benzenesulfonamides. Bioorg Med Chem. 2008 Mar 1;16(5):2697-706. DMY2OVL RU https://pubmed.ncbi.nlm.nih.gov/18063374 DMUQWJZ DI DMUQWJZ DMUQWJZ DN 4-(3-Hydroxy-piperidin-3-yl)-benzene-1,2-diol DMUQWJZ MI TTNGILX DMUQWJZ MN Adrenergic receptor alpha-1A (ADRA1A) DMUQWJZ MT DTT DMUQWJZ MA Inhibitor DMUQWJZ RN Conformational effects on the activity of drugs. 13. A revision of previously proposed models for the activation of alpha- and beta-adrenergic rece... J Med Chem. 1992 Mar 20;35(6):1009-18. DMUQWJZ RU https://pubmed.ncbi.nlm.nih.gov/1313109 DMUQWJZ DI DMUQWJZ DMUQWJZ DN 4-(3-Hydroxy-piperidin-3-yl)-benzene-1,2-diol DMUQWJZ MI TTBRKXS DMUQWJZ MN Adrenergic receptor alpha-1B (ADRA1B) DMUQWJZ MT DTT DMUQWJZ MA Inhibitor DMUQWJZ RN Conformational effects on the activity of drugs. 13. A revision of previously proposed models for the activation of alpha- and beta-adrenergic rece... J Med Chem. 1992 Mar 20;35(6):1009-18. DMUQWJZ RU https://pubmed.ncbi.nlm.nih.gov/1313109 DMUQWJZ DI DMUQWJZ DMUQWJZ DN 4-(3-Hydroxy-piperidin-3-yl)-benzene-1,2-diol DMUQWJZ MI TT34BHT DMUQWJZ MN Adrenergic receptor alpha-1D (ADRA1D) DMUQWJZ MT DTT DMUQWJZ MA Inhibitor DMUQWJZ RN Conformational effects on the activity of drugs. 13. A revision of previously proposed models for the activation of alpha- and beta-adrenergic rece... J Med Chem. 1992 Mar 20;35(6):1009-18. DMUQWJZ RU https://pubmed.ncbi.nlm.nih.gov/1313109 DMO8SQA DI DMO8SQA DMO8SQA DN 4-(3-methoxy-benzylideneamino)-benzenesulfonamide DMO8SQA MI TTVKILB DMO8SQA MN Prostaglandin G/H synthase 2 (COX-2) DMO8SQA MT DTT DMO8SQA MA Inhibitor DMO8SQA RN Selective COX-2 inhibitors. Part 2: synthesis and biological evaluation of 4-benzylideneamino- and 4-phenyliminomethyl-benzenesulfonamides. Bioorg Med Chem. 2008 Mar 1;16(5):2697-706. DMO8SQA RU https://pubmed.ncbi.nlm.nih.gov/18063374 DMTPL0C DI DMTPL0C DMTPL0C DN 4-(3-methoxybenzylthio)-2-aminobutanoic acid DMTPL0C MI TTFK1JQ DMTPL0C MN Voltage-gated calcium channel alpha-2/delta-1 (CACNA2D1) DMTPL0C MT DTT DMTPL0C MA Inhibitor DMTPL0C RN Structure-activity relationships of alpha-amino acid ligands for the alpha2delta subunit of voltage-gated calcium channels. Bioorg Med Chem Lett. 2006 Mar 1;16(5):1138-41. DMTPL0C RU https://pubmed.ncbi.nlm.nih.gov/16380257 DMSUFJZ DI DMSUFJZ DMSUFJZ DN 4-(3-Methoxy-phenyl)-isoxazolidine-3,5-dione DMSUFJZ MI TTFBNVI DMSUFJZ MN Aldose reductase (AKR1B1) DMSUFJZ MT DTT DMSUFJZ MA Inhibitor DMSUFJZ RN Isoxazolidine-3,5-diones as lens aldose reductase inhibitors. J Med Chem. 1982 Jun;25(6):745-7. DMSUFJZ RU https://pubmed.ncbi.nlm.nih.gov/6808134 DMGCPKU DI DMGCPKU DMGCPKU DN 4-(3-methoxyphenylethynyl)-2-methylthiazole DMGCPKU MI TTHS256 DMGCPKU MN Metabotropic glutamate receptor 5 (mGluR5) DMGCPKU MT DTT DMGCPKU MA Inhibitor DMGCPKU RN Synthesis and structure-activity relationships of 3-[(2-methyl-1,3-thiazol-4-yl)ethynyl]pyridine analogues as potent, noncompetitive metabotropic g... J Med Chem. 2006 Feb 9;49(3):1080-100. DMGCPKU RU https://pubmed.ncbi.nlm.nih.gov/16451073 DM67A4U DI DM67A4U DM67A4U DN 4-(3-Methyl-indole-1-sulfonyl)-phenylamine DM67A4U MI TTJS8PY DM67A4U MN 5-HT 6 receptor (HTR6) DM67A4U MT DTT DM67A4U MA Inhibitor DM67A4U RN 1-(1-Naphthyl)piperazine as a novel template for 5-HT6 serotonin receptor ligands. Bioorg Med Chem Lett. 2005 Mar 15;15(6):1707-11. DM67A4U RU https://pubmed.ncbi.nlm.nih.gov/15745826 DM5I6O2 DI DM5I6O2 DM5I6O2 DN 4-(3-methylpyridin-2-yl)-N-p-tolylbenzamide DM5I6O2 MI TTMI6F5 DM5I6O2 MN Transient receptor potential cation channel V1 (TRPV1) DM5I6O2 MT DTT DM5I6O2 MA Inhibitor DM5I6O2 RN From arylureas to biarylamides to aminoquinazolines: discovery of a novel, potent TRPV1 antagonist. Bioorg Med Chem Lett. 2006 Oct 1;16(19):5217-21. DM5I6O2 RU https://pubmed.ncbi.nlm.nih.gov/16870426 DMD94OB DI DMD94OB DMD94OB DN 4-(3-nitro-benzylideneamino)-benzenesulfonamide DMD94OB MI TTVKILB DMD94OB MN Prostaglandin G/H synthase 2 (COX-2) DMD94OB MT DTT DMD94OB MA Inhibitor DMD94OB RN Selective COX-2 inhibitors. Part 2: synthesis and biological evaluation of 4-benzylideneamino- and 4-phenyliminomethyl-benzenesulfonamides. Bioorg Med Chem. 2008 Mar 1;16(5):2697-706. DMD94OB RU https://pubmed.ncbi.nlm.nih.gov/18063374 DM4WI0Y DI DM4WI0Y DM4WI0Y DN 4-(3-nitrobenzylthio)-2-aminobutanoic acid DM4WI0Y MI TTFK1JQ DM4WI0Y MN Voltage-gated calcium channel alpha-2/delta-1 (CACNA2D1) DM4WI0Y MT DTT DM4WI0Y MA Inhibitor DM4WI0Y RN Structure-activity relationships of alpha-amino acid ligands for the alpha2delta subunit of voltage-gated calcium channels. Bioorg Med Chem Lett. 2006 Mar 1;16(5):1138-41. DM4WI0Y RU https://pubmed.ncbi.nlm.nih.gov/16380257 DMEYV1B DI DMEYV1B DMEYV1B DN 4-(3-Pent-1-ynyl-benzyl)-1H-imidazole DMEYV1B MI TTVG215 DMEYV1B MN Debrisoquine 4-hydroxylase (CYP2D6) DMEYV1B MT DTT DMEYV1B MA Inhibitor DMEYV1B RN 4-benzyl-1H-imidazoles with oxazoline termini as histamine H3 receptor agonists. J Med Chem. 2008 May 22;51(10):2944-53. DMEYV1B RU https://pubmed.ncbi.nlm.nih.gov/18433114 DMSXG23 DI DMSXG23 DMSXG23 DN 4-(3-phenoxylphenyl)-5-cyano-2H-1,2,3-triazole DMSXG23 MI TTR5TV4 DMSXG23 MN ERBB2 messenger RNA (HER2 mRNA) DMSXG23 MT DTT DMSXG23 MA Inhibitor DMSXG23 RN Synthesis and biological evaluation of 4-aryl-5-cyano-2H-1,2,3-triazoles as inhibitor of HER2 tyrosine kinase. Bioorg Med Chem. 2007 Feb 1;15(3):1533-8. DMSXG23 RU https://pubmed.ncbi.nlm.nih.gov/17174554 DM5F13I DI DM5F13I DM5F13I DN 4-(3-Phenoxy-propyl)-1H-imidazole DM5F13I MI TT9JNIC DM5F13I MN Histamine H3 receptor (H3R) DM5F13I MT DTT DM5F13I MA Inhibitor DM5F13I RN Different antagonist binding properties of human and rat histamine H3 receptors. Bioorg Med Chem Lett. 2001 Apr 9;11(7):951-4. DM5F13I RU https://pubmed.ncbi.nlm.nih.gov/11294398 DMEJF6V DI DMEJF6V DMEJF6V DN 4-(3-phenyl-1H-indol-2-yl)phenol DMEJF6V MI TTZAYWL DMEJF6V MN Estrogen receptor (ESR) DMEJF6V MT DTT DMEJF6V MA Inhibitor DMEJF6V RN Estrogen receptor beta selective ligands: discovery and SAR of novel heterocyclic ligands. Bioorg Med Chem Lett. 2005 Dec 15;15(24):5562-6. DMEJF6V RU https://pubmed.ncbi.nlm.nih.gov/16219463 DMEJF6V DI DMEJF6V DMEJF6V DN 4-(3-phenyl-1H-indol-2-yl)phenol DMEJF6V MI TTOM3J0 DMEJF6V MN Estrogen receptor beta (ESR2) DMEJF6V MT DTT DMEJF6V MA Inhibitor DMEJF6V RN Estrogen receptor beta selective ligands: discovery and SAR of novel heterocyclic ligands. Bioorg Med Chem Lett. 2005 Dec 15;15(24):5562-6. DMEJF6V RU https://pubmed.ncbi.nlm.nih.gov/16219463 DMS4JVT DI DMS4JVT DMS4JVT DN 4-(3-Phenylethynyl-benzyl)-1H-imidazole DMS4JVT MI TTVG215 DMS4JVT MN Debrisoquine 4-hydroxylase (CYP2D6) DMS4JVT MT DTT DMS4JVT MA Inhibitor DMS4JVT RN 4-benzyl-1H-imidazoles with oxazoline termini as histamine H3 receptor agonists. J Med Chem. 2008 May 22;51(10):2944-53. DMS4JVT RU https://pubmed.ncbi.nlm.nih.gov/18433114 DMRXKMP DI DMRXKMP DMRXKMP DN 4-(3-pyridylethynyl)-2-thiazolylamine DMRXKMP MI TTHS256 DMRXKMP MN Metabotropic glutamate receptor 5 (mGluR5) DMRXKMP MT DTT DMRXKMP MA Inhibitor DMRXKMP RN Synthesis and structure-activity relationships of 3-[(2-methyl-1,3-thiazol-4-yl)ethynyl]pyridine analogues as potent, noncompetitive metabotropic g... J Med Chem. 2006 Feb 9;49(3):1080-100. DMRXKMP RU https://pubmed.ncbi.nlm.nih.gov/16451073 DML4NJU DI DML4NJU DML4NJU DN 4-(3-thienyl)benzene-1,2-diamine) DML4NJU MI TTQ6VDM DML4NJU MN Voltage-gated potassium channel Kv11.1 (KCNH2) DML4NJU MT DTT DML4NJU MA Inhibitor DML4NJU RN Parallel medicinal chemistry approaches to selective HDAC1/HDAC2 inhibitor (SHI-1:2) optimization. Bioorg Med Chem Lett. 2009 Feb 15;19(4):1168-72. DML4NJU RU https://pubmed.ncbi.nlm.nih.gov/19138845 DM0QRJ3 DI DM0QRJ3 DM0QRJ3 DN 4-(4-((phenethylamino)methyl)phenoxy)benzamide DM0QRJ3 MI TT27RFC DM0QRJ3 MN Opioid receptor delta (OPRD1) DM0QRJ3 MT DTT DM0QRJ3 MA Inhibitor DM0QRJ3 RN Structure-activity relationship studies of carboxamido-biaryl ethers as opioid receptor antagonists (OpRAs). Part 1. Bioorg Med Chem Lett. 2007 Oct 1;17(19):5349-52. DM0QRJ3 RU https://pubmed.ncbi.nlm.nih.gov/17720493 DM0QRJ3 DI DM0QRJ3 DM0QRJ3 DN 4-(4-((phenethylamino)methyl)phenoxy)benzamide DM0QRJ3 MI TTQW87Y DM0QRJ3 MN Opioid receptor kappa (OPRK1) DM0QRJ3 MT DTT DM0QRJ3 MA Inhibitor DM0QRJ3 RN Structure-activity relationship studies of carboxamido-biaryl ethers as opioid receptor antagonists (OpRAs). Part 1. Bioorg Med Chem Lett. 2007 Oct 1;17(19):5349-52. DM0QRJ3 RU https://pubmed.ncbi.nlm.nih.gov/17720493 DM0QRJ3 DI DM0QRJ3 DM0QRJ3 DN 4-(4-((phenethylamino)methyl)phenoxy)benzamide DM0QRJ3 MI TTKWM86 DM0QRJ3 MN Opioid receptor mu (MOP) DM0QRJ3 MT DTT DM0QRJ3 MA Inhibitor DM0QRJ3 RN Structure-activity relationship studies of carboxamido-biaryl ethers as opioid receptor antagonists (OpRAs). Part 1. Bioorg Med Chem Lett. 2007 Oct 1;17(19):5349-52. DM0QRJ3 RU https://pubmed.ncbi.nlm.nih.gov/17720493 DMWBVMH DI DMWBVMH DMWBVMH DN 4-(4-(2-nitrovinyl)phenoxysulfonyl)benzoic acid DMWBVMH MI TTGKNB4 DMWBVMH MN Epidermal growth factor receptor (EGFR) DMWBVMH MT DTT DMWBVMH MA Inhibitor DMWBVMH RN Protein-tyrosine kinase inhibition: mechanism-based discovery of antitumor agents. J Nat Prod. 1992 Nov;55(11):1529-60. DMWBVMH RU https://pubmed.ncbi.nlm.nih.gov/1479375 DMA9TCD DI DMA9TCD DMA9TCD DN 4-(4-(4-Nitrophenyl)thiazol-2-ylamino)phenol DMA9TCD MI TTWHDVK DMA9TCD MN Fructose-1,6-bisphosphatase (FBP) DMA9TCD MT DTT DMA9TCD MA Inhibitor DMA9TCD RN A library of novel allosteric inhibitors against fructose 1,6-bisphosphatase. Bioorg Med Chem. 2009 Jun 1;17(11):3916-22. DMA9TCD RU https://pubmed.ncbi.nlm.nih.gov/19419876 DM6KIG0 DI DM6KIG0 DM6KIG0 DN 4-(4-(dec-1-ynyl)phenyl)-4-oxobutanoic acid DM6KIG0 MI TTXZ0KQ DM6KIG0 MN Matrix metalloproteinase-12 (MMP-12) DM6KIG0 MT DTT DM6KIG0 MA Inhibitor DM6KIG0 RN Selective inhibition of matrix metalloproteinase isozymes and in vivo protection against emphysema by substituted gamma-keto carboxylic acids. J Med Chem. 2006 Jan 26;49(2):456-8. DM6KIG0 RU https://pubmed.ncbi.nlm.nih.gov/16420030 DM6KIG0 DI DM6KIG0 DM6KIG0 DN 4-(4-(dec-1-ynyl)phenyl)-4-oxobutanoic acid DM6KIG0 MI TTLM12X DM6KIG0 MN Matrix metalloproteinase-2 (MMP-2) DM6KIG0 MT DTT DM6KIG0 MA Inhibitor DM6KIG0 RN Selective inhibition of matrix metalloproteinase isozymes and in vivo protection against emphysema by substituted gamma-keto carboxylic acids. J Med Chem. 2006 Jan 26;49(2):456-8. DM6KIG0 RU https://pubmed.ncbi.nlm.nih.gov/16420030 DMYXHUO DI DMYXHUO DMYXHUO DN 4-(4-(pentyloxy)phenoxy)phenol DMYXHUO MI TTXZEAJ DMYXHUO MN Leukotriene A-4 hydrolase (LTA4H) DMYXHUO MT DTT DMYXHUO MA Inhibitor DMYXHUO RN Activation and inhibition of leukotriene A4 hydrolase aminopeptidase activity by diphenyl ether and derivatives. Bioorg Med Chem Lett. 2008 Dec 15;18(24):6549-52. DMYXHUO RU https://pubmed.ncbi.nlm.nih.gov/18952425 DMVXJU6 DI DMVXJU6 DMVXJU6 DN 4-(4-(thiophen-2-yl)benzyl)pyridine DMVXJU6 MI TTIQUX7 DMVXJU6 MN Steroid 11-beta-hydroxylase (CYP11B1) DMVXJU6 MT DTT DMVXJU6 MA Inhibitor DMVXJU6 RN Replacement of imidazolyl by pyridyl in biphenylmethylenes results in selective CYP17 and dual CYP17/CYP11B1 inhibitors for the treatment of prosta... J Med Chem. 2010 Aug 12;53(15):5749-58. DMVXJU6 RU https://pubmed.ncbi.nlm.nih.gov/20684610 DMVXJU6 DI DMVXJU6 DMVXJU6 DN 4-(4-(thiophen-2-yl)benzyl)pyridine DMVXJU6 MI TTRA5BZ DMVXJU6 MN Steroid 17-alpha-monooxygenase (S17AH) DMVXJU6 MT DTT DMVXJU6 MA Inhibitor DMVXJU6 RN Replacement of imidazolyl by pyridyl in biphenylmethylenes results in selective CYP17 and dual CYP17/CYP11B1 inhibitors for the treatment of prosta... J Med Chem. 2010 Aug 12;53(15):5749-58. DMVXJU6 RU https://pubmed.ncbi.nlm.nih.gov/20684610 DM7I21V DI DM7I21V DM7I21V DN 4-(4-(thiophen-3-yl)benzyl)pyridine DM7I21V MI TTIQUX7 DM7I21V MN Steroid 11-beta-hydroxylase (CYP11B1) DM7I21V MT DTT DM7I21V MA Inhibitor DM7I21V RN Replacement of imidazolyl by pyridyl in biphenylmethylenes results in selective CYP17 and dual CYP17/CYP11B1 inhibitors for the treatment of prosta... J Med Chem. 2010 Aug 12;53(15):5749-58. DM7I21V RU https://pubmed.ncbi.nlm.nih.gov/20684610 DM7I21V DI DM7I21V DM7I21V DN 4-(4-(thiophen-3-yl)benzyl)pyridine DM7I21V MI TTRA5BZ DM7I21V MN Steroid 17-alpha-monooxygenase (S17AH) DM7I21V MT DTT DM7I21V MA Inhibitor DM7I21V RN Replacement of imidazolyl by pyridyl in biphenylmethylenes results in selective CYP17 and dual CYP17/CYP11B1 inhibitors for the treatment of prosta... J Med Chem. 2010 Aug 12;53(15):5749-58. DM7I21V RU https://pubmed.ncbi.nlm.nih.gov/20684610 DMOF0J1 DI DMOF0J1 DMOF0J1 DN 4-(4,5-dihydrothiazol-2-yl)phenyl butylcarbamate DMOF0J1 MI TTDP1UC DMOF0J1 MN Fatty acid amide hydrolase (FAAH) DMOF0J1 MT DTT DMOF0J1 MA Inhibitor DMOF0J1 RN The synthesis and biological evaluation of para-substituted phenolic N-alkyl carbamates as endocannabinoid hydrolyzing enzyme inhibitors. Eur J Med Chem. 2009 Jul;44(7):2994-3008. DMOF0J1 RU https://pubmed.ncbi.nlm.nih.gov/19232787 DMI1598 DI DMI1598 DMI1598 DN 4-(4,6-dinitro-1H-indol-1-ylsulfonyl)benzenamine DMI1598 MI TTJS8PY DMI1598 MN 5-HT 6 receptor (HTR6) DMI1598 MT DTT DMI1598 MA Inhibitor DMI1598 RN Binding of amine-substituted N1-benzenesulfonylindoles at human 5-HT6 serotonin receptors. Bioorg Med Chem Lett. 2005 Dec 1;15(23):5298-302. DMI1598 RU https://pubmed.ncbi.nlm.nih.gov/16183286 DMETK18 DI DMETK18 DMETK18 DN 4-(4,6-diphenylpyridin-2-yl)phenol DMETK18 MI TTGTQHC DMETK18 MN DNA topoisomerase I (TOP1) DMETK18 MT DTT DMETK18 MA Inhibitor DMETK18 RN Synthesis, topoisomerase I and II inhibitory activity, cytotoxicity, and structure-activity relationship study of hydroxylated 2,4-diphenyl-6-aryl ... Bioorg Med Chem. 2010 May 1;18(9):3066-77. DMETK18 RU https://pubmed.ncbi.nlm.nih.gov/20392646 DMGOTYC DI DMGOTYC DMGOTYC DN 4'-(4-Aminobenzensulfonamide)-4-hydroxychalcone DMGOTYC MI TTULVH8 DMGOTYC MN Tyrosinase (TYR) DMGOTYC MT DTT DMGOTYC MA Inhibitor DMGOTYC RN Evaluation of anti-pigmentary effect of synthetic sulfonylamino chalcone. Eur J Med Chem. 2010 May;45(5):2010-7. DMGOTYC RU https://pubmed.ncbi.nlm.nih.gov/20149498 DMK1IWD DI DMK1IWD DMK1IWD DN 4-(4-aminophenyl)-1H-indazol-3yl-amine DMK1IWD MI TTGJCWZ DMK1IWD MN Fms-like tyrosine kinase 3 (FLT-3) DMK1IWD MT DTT DMK1IWD MA Inhibitor DMK1IWD RN Discovery of N-(4-(3-amino-1H-indazol-4-yl)phenyl)-N'-(2-fluoro-5-methylphenyl)urea (ABT-869), a 3-aminoindazole-based orally active multitargeted ... J Med Chem. 2007 Apr 5;50(7):1584-97. DMK1IWD RU https://pubmed.ncbi.nlm.nih.gov/17343372 DMK1IWD DI DMK1IWD DMK1IWD DN 4-(4-aminophenyl)-1H-indazol-3yl-amine DMK1IWD MI TTX41N9 DMK1IWD MN Tyrosine-protein kinase Kit (KIT) DMK1IWD MT DTT DMK1IWD MA Inhibitor DMK1IWD RN Discovery of N-(4-(3-amino-1H-indazol-4-yl)phenyl)-N'-(2-fluoro-5-methylphenyl)urea (ABT-869), a 3-aminoindazole-based orally active multitargeted ... J Med Chem. 2007 Apr 5;50(7):1584-97. DMK1IWD RU https://pubmed.ncbi.nlm.nih.gov/17343372 DMK1IWD DI DMK1IWD DMK1IWD DN 4-(4-aminophenyl)-1H-indazol-3yl-amine DMK1IWD MI TTUTJGQ DMK1IWD MN Vascular endothelial growth factor receptor 2 (KDR) DMK1IWD MT DTT DMK1IWD MA Inhibitor DMK1IWD RN Discovery of N-(4-(3-amino-1H-indazol-4-yl)phenyl)-N'-(2-fluoro-5-methylphenyl)urea (ABT-869), a 3-aminoindazole-based orally active multitargeted ... J Med Chem. 2007 Apr 5;50(7):1584-97. DMK1IWD RU https://pubmed.ncbi.nlm.nih.gov/17343372 DMP0G1W DI DMP0G1W DMP0G1W DN 4-(4-benzenesulfonamidophenyl)piperazine DMP0G1W MI TTJS8PY DMP0G1W MN 5-HT 6 receptor (HTR6) DMP0G1W MT DTT DMP0G1W MA Inhibitor DMP0G1W RN Binding of sulfonyl-containing arylalkylamines at human 5-HT6 serotonin receptors. J Med Chem. 2006 Aug 24;49(17):5217-25. DMP0G1W RU https://pubmed.ncbi.nlm.nih.gov/16913710 DM0DZFX DI DM0DZFX DM0DZFX DN 4-(4-benzenesulfonylphenyl)piperazine DM0DZFX MI TTJS8PY DM0DZFX MN 5-HT 6 receptor (HTR6) DM0DZFX MT DTT DM0DZFX MA Inhibitor DM0DZFX RN Binding of sulfonyl-containing arylalkylamines at human 5-HT6 serotonin receptors. J Med Chem. 2006 Aug 24;49(17):5217-25. DM0DZFX RU https://pubmed.ncbi.nlm.nih.gov/16913710 DMT2S9U DI DMT2S9U DMT2S9U DN 4-(4-benzyl-1H-1,2,3-triazol-1-yl)phenol DMT2S9U MI TT6804T DMT2S9U MN MIF messenger RNA (MIF mRNA) DMT2S9U MT DTT DMT2S9U MA Inhibitor DMT2S9U RN Receptor agonists of macrophage migration inhibitory factor. Bioorg Med Chem Lett. 2010 Dec 1;20(23):7033-6. DMT2S9U RU https://pubmed.ncbi.nlm.nih.gov/20971005 DME3PUT DI DME3PUT DME3PUT DN 4-(4-Benzyloxy-3-methoxy-benzylamino)-benzamidine DME3PUT MI TT2WR1T DME3PUT MN Cationic trypsinogen (PRSS1) DME3PUT MT DTT DME3PUT MA Inhibitor DME3PUT RN Design of selective phenylglycine amide tissue factor/factor VIIa inhibitors. Bioorg Med Chem Lett. 2005 Feb 1;15(3):817-22. DME3PUT RU https://pubmed.ncbi.nlm.nih.gov/15664864 DME3PUT DI DME3PUT DME3PUT DN 4-(4-Benzyloxy-3-methoxy-benzylamino)-benzamidine DME3PUT MI TT6L509 DME3PUT MN Coagulation factor IIa (F2) DME3PUT MT DTT DME3PUT MA Inhibitor DME3PUT RN Design of selective phenylglycine amide tissue factor/factor VIIa inhibitors. Bioorg Med Chem Lett. 2005 Feb 1;15(3):817-22. DME3PUT RU https://pubmed.ncbi.nlm.nih.gov/15664864 DME3PUT DI DME3PUT DME3PUT DN 4-(4-Benzyloxy-3-methoxy-benzylamino)-benzamidine DME3PUT MI TTF0EGX DME3PUT MN Coagulation factor VII (F7) DME3PUT MT DTT DME3PUT MA Inhibitor DME3PUT RN Design of selective phenylglycine amide tissue factor/factor VIIa inhibitors. Bioorg Med Chem Lett. 2005 Feb 1;15(3):817-22. DME3PUT RU https://pubmed.ncbi.nlm.nih.gov/15664864 DME3PUT DI DME3PUT DME3PUT DN 4-(4-Benzyloxy-3-methoxy-benzylamino)-benzamidine DME3PUT MI TTCIHJA DME3PUT MN Coagulation factor Xa (F10) DME3PUT MT DTT DME3PUT MA Inhibitor DME3PUT RN Design of selective phenylglycine amide tissue factor/factor VIIa inhibitors. Bioorg Med Chem Lett. 2005 Feb 1;15(3):817-22. DME3PUT RU https://pubmed.ncbi.nlm.nih.gov/15664864 DMXAEW9 DI DMXAEW9 DMXAEW9 DN 4-(4-Benzyl-piperazin-1-yl)-1H-benzoimidazole DMXAEW9 MI TTEX248 DMXAEW9 MN Dopamine D2 receptor (D2R) DMXAEW9 MT DTT DMXAEW9 MA Inhibitor DMXAEW9 RN New generation dopaminergic agents. 5. Heterocyclic bioisosteres that exploit the 3-OH-N1-phenylpiperazine dopaminergic template. Bioorg Med Chem Lett. 1998 Oct 6;8(19):2675-80. DMXAEW9 RU https://pubmed.ncbi.nlm.nih.gov/9873601 DMXAEW9 DI DMXAEW9 DMXAEW9 DN 4-(4-Benzyl-piperazin-1-yl)-1H-benzoimidazole DMXAEW9 MI TT4C8EA DMXAEW9 MN Dopamine D3 receptor (D3R) DMXAEW9 MT DTT DMXAEW9 MA Inhibitor DMXAEW9 RN New generation dopaminergic agents. 5. Heterocyclic bioisosteres that exploit the 3-OH-N1-phenylpiperazine dopaminergic template. Bioorg Med Chem Lett. 1998 Oct 6;8(19):2675-80. DMXAEW9 RU https://pubmed.ncbi.nlm.nih.gov/9873601 DMXAEW9 DI DMXAEW9 DMXAEW9 DN 4-(4-Benzyl-piperazin-1-yl)-1H-benzoimidazole DMXAEW9 MI TTE0A2F DMXAEW9 MN Dopamine D4 receptor (D4R) DMXAEW9 MT DTT DMXAEW9 MA Inhibitor DMXAEW9 RN New generation dopaminergic agents. 5. Heterocyclic bioisosteres that exploit the 3-OH-N1-phenylpiperazine dopaminergic template. Bioorg Med Chem Lett. 1998 Oct 6;8(19):2675-80. DMXAEW9 RU https://pubmed.ncbi.nlm.nih.gov/9873601 DMWR0AS DI DMWR0AS DMWR0AS DN 4-(4-Benzyl-piperazin-1-yl)-1H-indole DMWR0AS MI TTEX248 DMWR0AS MN Dopamine D2 receptor (D2R) DMWR0AS MT DTT DMWR0AS MA Inhibitor DMWR0AS RN New generation dopaminergic agents. 5. Heterocyclic bioisosteres that exploit the 3-OH-N1-phenylpiperazine dopaminergic template. Bioorg Med Chem Lett. 1998 Oct 6;8(19):2675-80. DMWR0AS RU https://pubmed.ncbi.nlm.nih.gov/9873601 DMWR0AS DI DMWR0AS DMWR0AS DN 4-(4-Benzyl-piperazin-1-yl)-1H-indole DMWR0AS MI TT4C8EA DMWR0AS MN Dopamine D3 receptor (D3R) DMWR0AS MT DTT DMWR0AS MA Inhibitor DMWR0AS RN New generation dopaminergic agents. 5. Heterocyclic bioisosteres that exploit the 3-OH-N1-phenylpiperazine dopaminergic template. Bioorg Med Chem Lett. 1998 Oct 6;8(19):2675-80. DMWR0AS RU https://pubmed.ncbi.nlm.nih.gov/9873601 DMWR0AS DI DMWR0AS DMWR0AS DN 4-(4-Benzyl-piperazin-1-yl)-1H-indole DMWR0AS MI TTE0A2F DMWR0AS MN Dopamine D4 receptor (D4R) DMWR0AS MT DTT DMWR0AS MA Inhibitor DMWR0AS RN New generation dopaminergic agents. 5. Heterocyclic bioisosteres that exploit the 3-OH-N1-phenylpiperazine dopaminergic template. Bioorg Med Chem Lett. 1998 Oct 6;8(19):2675-80. DMWR0AS RU https://pubmed.ncbi.nlm.nih.gov/9873601 DMZ4237 DI DMZ4237 DMZ4237 DN 4-(4-Benzyl-piperazin-1-yl)-5-chloro-1H-indole DMZ4237 MI TTEX248 DMZ4237 MN Dopamine D2 receptor (D2R) DMZ4237 MT DTT DMZ4237 MA Inhibitor DMZ4237 RN New generation dopaminergic agents. 5. Heterocyclic bioisosteres that exploit the 3-OH-N1-phenylpiperazine dopaminergic template. Bioorg Med Chem Lett. 1998 Oct 6;8(19):2675-80. DMZ4237 RU https://pubmed.ncbi.nlm.nih.gov/9873601 DMZ4237 DI DMZ4237 DMZ4237 DN 4-(4-Benzyl-piperazin-1-yl)-5-chloro-1H-indole DMZ4237 MI TT4C8EA DMZ4237 MN Dopamine D3 receptor (D3R) DMZ4237 MT DTT DMZ4237 MA Inhibitor DMZ4237 RN New generation dopaminergic agents. 5. Heterocyclic bioisosteres that exploit the 3-OH-N1-phenylpiperazine dopaminergic template. Bioorg Med Chem Lett. 1998 Oct 6;8(19):2675-80. DMZ4237 RU https://pubmed.ncbi.nlm.nih.gov/9873601 DMZ4237 DI DMZ4237 DMZ4237 DN 4-(4-Benzyl-piperazin-1-yl)-5-chloro-1H-indole DMZ4237 MI TTE0A2F DMZ4237 MN Dopamine D4 receptor (D4R) DMZ4237 MT DTT DMZ4237 MA Inhibitor DMZ4237 RN New generation dopaminergic agents. 5. Heterocyclic bioisosteres that exploit the 3-OH-N1-phenylpiperazine dopaminergic template. Bioorg Med Chem Lett. 1998 Oct 6;8(19):2675-80. DMZ4237 RU https://pubmed.ncbi.nlm.nih.gov/9873601 DMVAB7U DI DMVAB7U DMVAB7U DN 4-(4-Benzyl-piperazin-1-yl)-7-bromo-1H-indole DMVAB7U MI TTEX248 DMVAB7U MN Dopamine D2 receptor (D2R) DMVAB7U MT DTT DMVAB7U MA Inhibitor DMVAB7U RN New generation dopaminergic agents. 5. Heterocyclic bioisosteres that exploit the 3-OH-N1-phenylpiperazine dopaminergic template. Bioorg Med Chem Lett. 1998 Oct 6;8(19):2675-80. DMVAB7U RU https://pubmed.ncbi.nlm.nih.gov/9873601 DMVAB7U DI DMVAB7U DMVAB7U DN 4-(4-Benzyl-piperazin-1-yl)-7-bromo-1H-indole DMVAB7U MI TT4C8EA DMVAB7U MN Dopamine D3 receptor (D3R) DMVAB7U MT DTT DMVAB7U MA Inhibitor DMVAB7U RN New generation dopaminergic agents. 5. Heterocyclic bioisosteres that exploit the 3-OH-N1-phenylpiperazine dopaminergic template. Bioorg Med Chem Lett. 1998 Oct 6;8(19):2675-80. DMVAB7U RU https://pubmed.ncbi.nlm.nih.gov/9873601 DMVAB7U DI DMVAB7U DMVAB7U DN 4-(4-Benzyl-piperazin-1-yl)-7-bromo-1H-indole DMVAB7U MI TTE0A2F DMVAB7U MN Dopamine D4 receptor (D4R) DMVAB7U MT DTT DMVAB7U MA Inhibitor DMVAB7U RN New generation dopaminergic agents. 5. Heterocyclic bioisosteres that exploit the 3-OH-N1-phenylpiperazine dopaminergic template. Bioorg Med Chem Lett. 1998 Oct 6;8(19):2675-80. DMVAB7U RU https://pubmed.ncbi.nlm.nih.gov/9873601 DMHWIMO DI DMHWIMO DMHWIMO DN 4-(4-bromobenzylthio)-2-aminobutanoic acid DMHWIMO MI TTFK1JQ DMHWIMO MN Voltage-gated calcium channel alpha-2/delta-1 (CACNA2D1) DMHWIMO MT DTT DMHWIMO MA Inhibitor DMHWIMO RN Structure-activity relationships of alpha-amino acid ligands for the alpha2delta subunit of voltage-gated calcium channels. Bioorg Med Chem Lett. 2006 Mar 1;16(5):1138-41. DMHWIMO RU https://pubmed.ncbi.nlm.nih.gov/16380257 DMFEBCO DI DMFEBCO DMFEBCO DN 4-(4-bromophenyl)-5-cyano-2H-1,2,3-triazole DMFEBCO MI TTR5TV4 DMFEBCO MN ERBB2 messenger RNA (HER2 mRNA) DMFEBCO MT DTT DMFEBCO MA Inhibitor DMFEBCO RN Synthesis and biological evaluation of 4-aryl-5-cyano-2H-1,2,3-triazoles as inhibitor of HER2 tyrosine kinase. Bioorg Med Chem. 2007 Feb 1;15(3):1533-8. DMFEBCO RU https://pubmed.ncbi.nlm.nih.gov/17174554 DMI2EM5 DI DMI2EM5 DMI2EM5 DN 4-(4-butoxyphenoxy)phenol DMI2EM5 MI TTXZEAJ DMI2EM5 MN Leukotriene A-4 hydrolase (LTA4H) DMI2EM5 MT DTT DMI2EM5 MA Inhibitor DMI2EM5 RN Activation and inhibition of leukotriene A4 hydrolase aminopeptidase activity by diphenyl ether and derivatives. Bioorg Med Chem Lett. 2008 Dec 15;18(24):6549-52. DMI2EM5 RU https://pubmed.ncbi.nlm.nih.gov/18952425 DMNGDOM DI DMNGDOM DMNGDOM DN 4-(4-Butoxy-phenyl)-N-hydroxy-4-oxo-butyramide DMNGDOM MI TTMX39J DMNGDOM MN Matrix metalloproteinase-1 (MMP-1) DMNGDOM MT DTT DMNGDOM MA Inhibitor DMNGDOM RN Receptor flexibility in de novo ligand design and docking. J Med Chem. 2005 Oct 20;48(21):6585-96. DMNGDOM RU https://pubmed.ncbi.nlm.nih.gov/16220975 DMM9X0G DI DMM9X0G DMM9X0G DN 4-(4-butylpiperidin-1-yl)-1-o-tolylbutan-1-one DMM9X0G MI TTSQIFT DMM9X0G MN 5-HT 1A receptor (HTR1A) DMM9X0G MT DTT DMM9X0G MA Inhibitor DMM9X0G RN Discovery of N-{1-[3-(3-oxo-2,3-dihydrobenzo[1,4]oxazin-4-yl)propyl]piperidin-4-yl}-2-phenylacetamide (Lu AE51090): an allosteric muscarinic M1 rec... J Med Chem. 2010 Sep 9;53(17):6386-97. DMM9X0G RU https://pubmed.ncbi.nlm.nih.gov/20684563 DMM9X0G DI DMM9X0G DMM9X0G DN 4-(4-butylpiperidin-1-yl)-1-o-tolylbutan-1-one DMM9X0G MI TTJQOD7 DMM9X0G MN 5-HT 2A receptor (HTR2A) DMM9X0G MT DTT DMM9X0G MA Inhibitor DMM9X0G RN Discovery of N-{1-[3-(3-oxo-2,3-dihydrobenzo[1,4]oxazin-4-yl)propyl]piperidin-4-yl}-2-phenylacetamide (Lu AE51090): an allosteric muscarinic M1 rec... J Med Chem. 2010 Sep 9;53(17):6386-97. DMM9X0G RU https://pubmed.ncbi.nlm.nih.gov/20684563 DMM9X0G DI DMM9X0G DMM9X0G DN 4-(4-butylpiperidin-1-yl)-1-o-tolylbutan-1-one DMM9X0G MI TT0K1SC DMM9X0G MN 5-HT 2B receptor (HTR2B) DMM9X0G MT DTT DMM9X0G MA Inhibitor DMM9X0G RN Discovery of N-{1-[3-(3-oxo-2,3-dihydrobenzo[1,4]oxazin-4-yl)propyl]piperidin-4-yl}-2-phenylacetamide (Lu AE51090): an allosteric muscarinic M1 rec... J Med Chem. 2010 Sep 9;53(17):6386-97. DMM9X0G RU https://pubmed.ncbi.nlm.nih.gov/20684563 DMM9X0G DI DMM9X0G DMM9X0G DN 4-(4-butylpiperidin-1-yl)-1-o-tolylbutan-1-one DMM9X0G MI TTWJBZ5 DMM9X0G MN 5-HT 2C receptor (HTR2C) DMM9X0G MT DTT DMM9X0G MA Inhibitor DMM9X0G RN Discovery of N-{1-[3-(3-oxo-2,3-dihydrobenzo[1,4]oxazin-4-yl)propyl]piperidin-4-yl}-2-phenylacetamide (Lu AE51090): an allosteric muscarinic M1 rec... J Med Chem. 2010 Sep 9;53(17):6386-97. DMM9X0G RU https://pubmed.ncbi.nlm.nih.gov/20684563 DMM9X0G DI DMM9X0G DMM9X0G DN 4-(4-butylpiperidin-1-yl)-1-o-tolylbutan-1-one DMM9X0G MI TTPC4TU DMM9X0G MN 5-HT 3A receptor (HTR3A) DMM9X0G MT DTT DMM9X0G MA Inhibitor DMM9X0G RN Discovery of N-{1-[3-(3-oxo-2,3-dihydrobenzo[1,4]oxazin-4-yl)propyl]piperidin-4-yl}-2-phenylacetamide (Lu AE51090): an allosteric muscarinic M1 rec... J Med Chem. 2010 Sep 9;53(17):6386-97. DMM9X0G RU https://pubmed.ncbi.nlm.nih.gov/20684563 DMM9X0G DI DMM9X0G DMM9X0G DN 4-(4-butylpiperidin-1-yl)-1-o-tolylbutan-1-one DMM9X0G MI TT07C3Y DMM9X0G MN 5-HT 4 receptor (HTR4) DMM9X0G MT DTT DMM9X0G MA Inhibitor DMM9X0G RN Discovery of N-{1-[3-(3-oxo-2,3-dihydrobenzo[1,4]oxazin-4-yl)propyl]piperidin-4-yl}-2-phenylacetamide (Lu AE51090): an allosteric muscarinic M1 rec... J Med Chem. 2010 Sep 9;53(17):6386-97. DMM9X0G RU https://pubmed.ncbi.nlm.nih.gov/20684563 DMM9X0G DI DMM9X0G DMM9X0G DN 4-(4-butylpiperidin-1-yl)-1-o-tolylbutan-1-one DMM9X0G MI TTO9X1H DMM9X0G MN 5-HT 7 receptor (HTR7) DMM9X0G MT DTT DMM9X0G MA Inhibitor DMM9X0G RN Discovery of N-{1-[3-(3-oxo-2,3-dihydrobenzo[1,4]oxazin-4-yl)propyl]piperidin-4-yl}-2-phenylacetamide (Lu AE51090): an allosteric muscarinic M1 rec... J Med Chem. 2010 Sep 9;53(17):6386-97. DMM9X0G RU https://pubmed.ncbi.nlm.nih.gov/20684563 DMM9X0G DI DMM9X0G DMM9X0G DN 4-(4-butylpiperidin-1-yl)-1-o-tolylbutan-1-one DMM9X0G MI TT1RS9F DMM9X0G MN Acetylcholinesterase (AChE) DMM9X0G MT DTT DMM9X0G MA Inhibitor DMM9X0G RN Discovery of N-{1-[3-(3-oxo-2,3-dihydrobenzo[1,4]oxazin-4-yl)propyl]piperidin-4-yl}-2-phenylacetamide (Lu AE51090): an allosteric muscarinic M1 rec... J Med Chem. 2010 Sep 9;53(17):6386-97. DMM9X0G RU https://pubmed.ncbi.nlm.nih.gov/20684563 DMM9X0G DI DMM9X0G DMM9X0G DN 4-(4-butylpiperidin-1-yl)-1-o-tolylbutan-1-one DMM9X0G MI TTK25J1 DMM9X0G MN Adenosine A1 receptor (ADORA1) DMM9X0G MT DTT DMM9X0G MA Inhibitor DMM9X0G RN Discovery of N-{1-[3-(3-oxo-2,3-dihydrobenzo[1,4]oxazin-4-yl)propyl]piperidin-4-yl}-2-phenylacetamide (Lu AE51090): an allosteric muscarinic M1 rec... J Med Chem. 2010 Sep 9;53(17):6386-97. DMM9X0G RU https://pubmed.ncbi.nlm.nih.gov/20684563 DMM9X0G DI DMM9X0G DMM9X0G DN 4-(4-butylpiperidin-1-yl)-1-o-tolylbutan-1-one DMM9X0G MI TTM2AOE DMM9X0G MN Adenosine A2a receptor (ADORA2A) DMM9X0G MT DTT DMM9X0G MA Inhibitor DMM9X0G RN Discovery of N-{1-[3-(3-oxo-2,3-dihydrobenzo[1,4]oxazin-4-yl)propyl]piperidin-4-yl}-2-phenylacetamide (Lu AE51090): an allosteric muscarinic M1 rec... J Med Chem. 2010 Sep 9;53(17):6386-97. DMM9X0G RU https://pubmed.ncbi.nlm.nih.gov/20684563 DMM9X0G DI DMM9X0G DMM9X0G DN 4-(4-butylpiperidin-1-yl)-1-o-tolylbutan-1-one DMM9X0G MI TTJFY5U DMM9X0G MN Adenosine A3 receptor (ADORA3) DMM9X0G MT DTT DMM9X0G MA Inhibitor DMM9X0G RN Discovery of N-{1-[3-(3-oxo-2,3-dihydrobenzo[1,4]oxazin-4-yl)propyl]piperidin-4-yl}-2-phenylacetamide (Lu AE51090): an allosteric muscarinic M1 rec... J Med Chem. 2010 Sep 9;53(17):6386-97. DMM9X0G RU https://pubmed.ncbi.nlm.nih.gov/20684563 DMM9X0G DI DMM9X0G DMM9X0G DN 4-(4-butylpiperidin-1-yl)-1-o-tolylbutan-1-one DMM9X0G MI TTNGILX DMM9X0G MN Adrenergic receptor alpha-1A (ADRA1A) DMM9X0G MT DTT DMM9X0G MA Inhibitor DMM9X0G RN Discovery of N-{1-[3-(3-oxo-2,3-dihydrobenzo[1,4]oxazin-4-yl)propyl]piperidin-4-yl}-2-phenylacetamide (Lu AE51090): an allosteric muscarinic M1 rec... J Med Chem. 2010 Sep 9;53(17):6386-97. DMM9X0G RU https://pubmed.ncbi.nlm.nih.gov/20684563 DMM9X0G DI DMM9X0G DMM9X0G DN 4-(4-butylpiperidin-1-yl)-1-o-tolylbutan-1-one DMM9X0G MI TTBRKXS DMM9X0G MN Adrenergic receptor alpha-1B (ADRA1B) DMM9X0G MT DTT DMM9X0G MA Inhibitor DMM9X0G RN Discovery of N-{1-[3-(3-oxo-2,3-dihydrobenzo[1,4]oxazin-4-yl)propyl]piperidin-4-yl}-2-phenylacetamide (Lu AE51090): an allosteric muscarinic M1 rec... J Med Chem. 2010 Sep 9;53(17):6386-97. DMM9X0G RU https://pubmed.ncbi.nlm.nih.gov/20684563 DMM9X0G DI DMM9X0G DMM9X0G DN 4-(4-butylpiperidin-1-yl)-1-o-tolylbutan-1-one DMM9X0G MI TT34BHT DMM9X0G MN Adrenergic receptor alpha-1D (ADRA1D) DMM9X0G MT DTT DMM9X0G MA Inhibitor DMM9X0G RN Discovery of N-{1-[3-(3-oxo-2,3-dihydrobenzo[1,4]oxazin-4-yl)propyl]piperidin-4-yl}-2-phenylacetamide (Lu AE51090): an allosteric muscarinic M1 rec... J Med Chem. 2010 Sep 9;53(17):6386-97. DMM9X0G RU https://pubmed.ncbi.nlm.nih.gov/20684563 DMM9X0G DI DMM9X0G DMM9X0G DN 4-(4-butylpiperidin-1-yl)-1-o-tolylbutan-1-one DMM9X0G MI TTWG9A4 DMM9X0G MN Adrenergic receptor alpha-2A (ADRA2A) DMM9X0G MT DTT DMM9X0G MA Inhibitor DMM9X0G RN Discovery of N-{1-[3-(3-oxo-2,3-dihydrobenzo[1,4]oxazin-4-yl)propyl]piperidin-4-yl}-2-phenylacetamide (Lu AE51090): an allosteric muscarinic M1 rec... J Med Chem. 2010 Sep 9;53(17):6386-97. DMM9X0G RU https://pubmed.ncbi.nlm.nih.gov/20684563 DMM9X0G DI DMM9X0G DMM9X0G DN 4-(4-butylpiperidin-1-yl)-1-o-tolylbutan-1-one DMM9X0G MI TTR6W5O DMM9X0G MN Adrenergic receptor beta-1 (ADRB1) DMM9X0G MT DTT DMM9X0G MA Inhibitor DMM9X0G RN Discovery of N-{1-[3-(3-oxo-2,3-dihydrobenzo[1,4]oxazin-4-yl)propyl]piperidin-4-yl}-2-phenylacetamide (Lu AE51090): an allosteric muscarinic M1 rec... J Med Chem. 2010 Sep 9;53(17):6386-97. DMM9X0G RU https://pubmed.ncbi.nlm.nih.gov/20684563 DMM9X0G DI DMM9X0G DMM9X0G DN 4-(4-butylpiperidin-1-yl)-1-o-tolylbutan-1-one DMM9X0G MI TT6OEDT DMM9X0G MN Cannabinoid receptor 1 (CB1) DMM9X0G MT DTT DMM9X0G MA Inhibitor DMM9X0G RN Discovery of N-{1-[3-(3-oxo-2,3-dihydrobenzo[1,4]oxazin-4-yl)propyl]piperidin-4-yl}-2-phenylacetamide (Lu AE51090): an allosteric muscarinic M1 rec... J Med Chem. 2010 Sep 9;53(17):6386-97. DMM9X0G RU https://pubmed.ncbi.nlm.nih.gov/20684563 DMM9X0G DI DMM9X0G DMM9X0G DN 4-(4-butylpiperidin-1-yl)-1-o-tolylbutan-1-one DMM9X0G MI TTZFYLI DMM9X0G MN Dopamine D1 receptor (D1R) DMM9X0G MT DTT DMM9X0G MA Inhibitor DMM9X0G RN Discovery of N-{1-[3-(3-oxo-2,3-dihydrobenzo[1,4]oxazin-4-yl)propyl]piperidin-4-yl}-2-phenylacetamide (Lu AE51090): an allosteric muscarinic M1 rec... J Med Chem. 2010 Sep 9;53(17):6386-97. DMM9X0G RU https://pubmed.ncbi.nlm.nih.gov/20684563 DMM9X0G DI DMM9X0G DMM9X0G DN 4-(4-butylpiperidin-1-yl)-1-o-tolylbutan-1-one DMM9X0G MI TTEX248 DMM9X0G MN Dopamine D2 receptor (D2R) DMM9X0G MT DTT DMM9X0G MA Inhibitor DMM9X0G RN Discovery of N-{1-[3-(3-oxo-2,3-dihydrobenzo[1,4]oxazin-4-yl)propyl]piperidin-4-yl}-2-phenylacetamide (Lu AE51090): an allosteric muscarinic M1 rec... J Med Chem. 2010 Sep 9;53(17):6386-97. DMM9X0G RU https://pubmed.ncbi.nlm.nih.gov/20684563 DMM9X0G DI DMM9X0G DMM9X0G DN 4-(4-butylpiperidin-1-yl)-1-o-tolylbutan-1-one DMM9X0G MI TT4C8EA DMM9X0G MN Dopamine D3 receptor (D3R) DMM9X0G MT DTT DMM9X0G MA Inhibitor DMM9X0G RN Discovery of N-{1-[3-(3-oxo-2,3-dihydrobenzo[1,4]oxazin-4-yl)propyl]piperidin-4-yl}-2-phenylacetamide (Lu AE51090): an allosteric muscarinic M1 rec... J Med Chem. 2010 Sep 9;53(17):6386-97. DMM9X0G RU https://pubmed.ncbi.nlm.nih.gov/20684563 DMM9X0G DI DMM9X0G DMM9X0G DN 4-(4-butylpiperidin-1-yl)-1-o-tolylbutan-1-one DMM9X0G MI TTVBI8W DMM9X0G MN Dopamine transporter (DAT) DMM9X0G MT DTT DMM9X0G MA Inhibitor DMM9X0G RN Discovery of N-{1-[3-(3-oxo-2,3-dihydrobenzo[1,4]oxazin-4-yl)propyl]piperidin-4-yl}-2-phenylacetamide (Lu AE51090): an allosteric muscarinic M1 rec... J Med Chem. 2010 Sep 9;53(17):6386-97. DMM9X0G RU https://pubmed.ncbi.nlm.nih.gov/20684563 DMM9X0G DI DMM9X0G DMM9X0G DN 4-(4-butylpiperidin-1-yl)-1-o-tolylbutan-1-one DMM9X0G MI TTKRD0G DMM9X0G MN Endothelin A receptor (EDNRA) DMM9X0G MT DTT DMM9X0G MA Inhibitor DMM9X0G RN Discovery of N-{1-[3-(3-oxo-2,3-dihydrobenzo[1,4]oxazin-4-yl)propyl]piperidin-4-yl}-2-phenylacetamide (Lu AE51090): an allosteric muscarinic M1 rec... J Med Chem. 2010 Sep 9;53(17):6386-97. DMM9X0G RU https://pubmed.ncbi.nlm.nih.gov/20684563 DMM9X0G DI DMM9X0G DMM9X0G DN 4-(4-butylpiperidin-1-yl)-1-o-tolylbutan-1-one DMM9X0G MI TTVFO0U DMM9X0G MN Gastrin/cholecystokinin type B receptor (CCKBR) DMM9X0G MT DTT DMM9X0G MA Inhibitor DMM9X0G RN Discovery of N-{1-[3-(3-oxo-2,3-dihydrobenzo[1,4]oxazin-4-yl)propyl]piperidin-4-yl}-2-phenylacetamide (Lu AE51090): an allosteric muscarinic M1 rec... J Med Chem. 2010 Sep 9;53(17):6386-97. DMM9X0G RU https://pubmed.ncbi.nlm.nih.gov/20684563 DMM9X0G DI DMM9X0G DMM9X0G DN 4-(4-butylpiperidin-1-yl)-1-o-tolylbutan-1-one DMM9X0G MI TTOZRK6 DMM9X0G MN Glucocorticoid receptor messenger RNA (GCR mRNA) DMM9X0G MT DTT DMM9X0G MA Inhibitor DMM9X0G RN Discovery of N-{1-[3-(3-oxo-2,3-dihydrobenzo[1,4]oxazin-4-yl)propyl]piperidin-4-yl}-2-phenylacetamide (Lu AE51090): an allosteric muscarinic M1 rec... J Med Chem. 2010 Sep 9;53(17):6386-97. DMM9X0G RU https://pubmed.ncbi.nlm.nih.gov/20684563 DMM9X0G DI DMM9X0G DMM9X0G DN 4-(4-butylpiperidin-1-yl)-1-o-tolylbutan-1-one DMM9X0G MI TTTIBOJ DMM9X0G MN Histamine H1 receptor (H1R) DMM9X0G MT DTT DMM9X0G MA Inhibitor DMM9X0G RN Discovery of N-{1-[3-(3-oxo-2,3-dihydrobenzo[1,4]oxazin-4-yl)propyl]piperidin-4-yl}-2-phenylacetamide (Lu AE51090): an allosteric muscarinic M1 rec... J Med Chem. 2010 Sep 9;53(17):6386-97. DMM9X0G RU https://pubmed.ncbi.nlm.nih.gov/20684563 DMM9X0G DI DMM9X0G DMM9X0G DN 4-(4-butylpiperidin-1-yl)-1-o-tolylbutan-1-one DMM9X0G MI TTQHJ1K DMM9X0G MN Histamine H2 receptor (H2R) DMM9X0G MT DTT DMM9X0G MA Inhibitor DMM9X0G RN Discovery of N-{1-[3-(3-oxo-2,3-dihydrobenzo[1,4]oxazin-4-yl)propyl]piperidin-4-yl}-2-phenylacetamide (Lu AE51090): an allosteric muscarinic M1 rec... J Med Chem. 2010 Sep 9;53(17):6386-97. DMM9X0G RU https://pubmed.ncbi.nlm.nih.gov/20684563 DMM9X0G DI DMM9X0G DMM9X0G DN 4-(4-butylpiperidin-1-yl)-1-o-tolylbutan-1-one DMM9X0G MI TT9JNIC DMM9X0G MN Histamine H3 receptor (H3R) DMM9X0G MT DTT DMM9X0G MA Inhibitor DMM9X0G RN Discovery of N-{1-[3-(3-oxo-2,3-dihydrobenzo[1,4]oxazin-4-yl)propyl]piperidin-4-yl}-2-phenylacetamide (Lu AE51090): an allosteric muscarinic M1 rec... J Med Chem. 2010 Sep 9;53(17):6386-97. DMM9X0G RU https://pubmed.ncbi.nlm.nih.gov/20684563 DMM9X0G DI DMM9X0G DMM9X0G DN 4-(4-butylpiperidin-1-yl)-1-o-tolylbutan-1-one DMM9X0G MI TTD0CIQ DMM9X0G MN Melanocortin receptor 4 (MC4R) DMM9X0G MT DTT DMM9X0G MA Inhibitor DMM9X0G RN Discovery of N-{1-[3-(3-oxo-2,3-dihydrobenzo[1,4]oxazin-4-yl)propyl]piperidin-4-yl}-2-phenylacetamide (Lu AE51090): an allosteric muscarinic M1 rec... J Med Chem. 2010 Sep 9;53(17):6386-97. DMM9X0G RU https://pubmed.ncbi.nlm.nih.gov/20684563 DMM9X0G DI DMM9X0G DMM9X0G DN 4-(4-butylpiperidin-1-yl)-1-o-tolylbutan-1-one DMM9X0G MI TT0WAIE DMM9X0G MN Melatonin receptor type 1A (MTNR1A) DMM9X0G MT DTT DMM9X0G MA Inhibitor DMM9X0G RN Discovery of N-{1-[3-(3-oxo-2,3-dihydrobenzo[1,4]oxazin-4-yl)propyl]piperidin-4-yl}-2-phenylacetamide (Lu AE51090): an allosteric muscarinic M1 rec... J Med Chem. 2010 Sep 9;53(17):6386-97. DMM9X0G RU https://pubmed.ncbi.nlm.nih.gov/20684563 DMM9X0G DI DMM9X0G DMM9X0G DN 4-(4-butylpiperidin-1-yl)-1-o-tolylbutan-1-one DMM9X0G MI TTZ9SOR DMM9X0G MN Muscarinic acetylcholine receptor M1 (CHRM1) DMM9X0G MT DTT DMM9X0G MA Inhibitor DMM9X0G RN Pharmacological comparison of muscarinic ligands: historical versus more recent muscarinic M1-preferring receptor agonists. Eur J Pharmacol. 2009 Mar 1;605(1-3):53-6. DMM9X0G RU https://pubmed.ncbi.nlm.nih.gov/19168056 DMM9X0G DI DMM9X0G DMM9X0G DN 4-(4-butylpiperidin-1-yl)-1-o-tolylbutan-1-one DMM9X0G MI TTYEG6Q DMM9X0G MN Muscarinic acetylcholine receptor M2 (CHRM2) DMM9X0G MT DTT DMM9X0G MA Inhibitor DMM9X0G RN Discovery of N-{1-[3-(3-oxo-2,3-dihydrobenzo[1,4]oxazin-4-yl)propyl]piperidin-4-yl}-2-phenylacetamide (Lu AE51090): an allosteric muscarinic M1 rec... J Med Chem. 2010 Sep 9;53(17):6386-97. DMM9X0G RU https://pubmed.ncbi.nlm.nih.gov/20684563 DMM9X0G DI DMM9X0G DMM9X0G DN 4-(4-butylpiperidin-1-yl)-1-o-tolylbutan-1-one DMM9X0G MI TTQ13Z5 DMM9X0G MN Muscarinic acetylcholine receptor M3 (CHRM3) DMM9X0G MT DTT DMM9X0G MA Inhibitor DMM9X0G RN Discovery of N-{1-[3-(3-oxo-2,3-dihydrobenzo[1,4]oxazin-4-yl)propyl]piperidin-4-yl}-2-phenylacetamide (Lu AE51090): an allosteric muscarinic M1 rec... J Med Chem. 2010 Sep 9;53(17):6386-97. DMM9X0G RU https://pubmed.ncbi.nlm.nih.gov/20684563 DMM9X0G DI DMM9X0G DMM9X0G DN 4-(4-butylpiperidin-1-yl)-1-o-tolylbutan-1-one DMM9X0G MI TTQ3JTF DMM9X0G MN Muscarinic acetylcholine receptor M4 (CHRM4) DMM9X0G MT DTT DMM9X0G MA Inhibitor DMM9X0G RN Discovery of N-{1-[3-(3-oxo-2,3-dihydrobenzo[1,4]oxazin-4-yl)propyl]piperidin-4-yl}-2-phenylacetamide (Lu AE51090): an allosteric muscarinic M1 rec... J Med Chem. 2010 Sep 9;53(17):6386-97. DMM9X0G RU https://pubmed.ncbi.nlm.nih.gov/20684563 DMM9X0G DI DMM9X0G DMM9X0G DN 4-(4-butylpiperidin-1-yl)-1-o-tolylbutan-1-one DMM9X0G MI TTH18TF DMM9X0G MN Muscarinic acetylcholine receptor M5 (CHRM5) DMM9X0G MT DTT DMM9X0G MA Inhibitor DMM9X0G RN Discovery of N-{1-[3-(3-oxo-2,3-dihydrobenzo[1,4]oxazin-4-yl)propyl]piperidin-4-yl}-2-phenylacetamide (Lu AE51090): an allosteric muscarinic M1 rec... J Med Chem. 2010 Sep 9;53(17):6386-97. DMM9X0G RU https://pubmed.ncbi.nlm.nih.gov/20684563 DMM9X0G DI DMM9X0G DMM9X0G DN 4-(4-butylpiperidin-1-yl)-1-o-tolylbutan-1-one DMM9X0G MI TT4H1MQ DMM9X0G MN Neuronal acetylcholine receptor alpha-4 (CHRNA4) DMM9X0G MT DTT DMM9X0G MA Inhibitor DMM9X0G RN Discovery of N-{1-[3-(3-oxo-2,3-dihydrobenzo[1,4]oxazin-4-yl)propyl]piperidin-4-yl}-2-phenylacetamide (Lu AE51090): an allosteric muscarinic M1 rec... J Med Chem. 2010 Sep 9;53(17):6386-97. DMM9X0G RU https://pubmed.ncbi.nlm.nih.gov/20684563 DMM9X0G DI DMM9X0G DMM9X0G DN 4-(4-butylpiperidin-1-yl)-1-o-tolylbutan-1-one DMM9X0G MI TT5KPZR DMM9X0G MN Neuronal acetylcholine receptor beta-2 (CHRNB2) DMM9X0G MT DTT DMM9X0G MA Inhibitor DMM9X0G RN Discovery of N-{1-[3-(3-oxo-2,3-dihydrobenzo[1,4]oxazin-4-yl)propyl]piperidin-4-yl}-2-phenylacetamide (Lu AE51090): an allosteric muscarinic M1 rec... J Med Chem. 2010 Sep 9;53(17):6386-97. DMM9X0G RU https://pubmed.ncbi.nlm.nih.gov/20684563 DMM9X0G DI DMM9X0G DMM9X0G DN 4-(4-butylpiperidin-1-yl)-1-o-tolylbutan-1-one DMM9X0G MI TTRK9JT DMM9X0G MN Neuropeptide Y receptor type 1 (NPY1R) DMM9X0G MT DTT DMM9X0G MA Inhibitor DMM9X0G RN Discovery of N-{1-[3-(3-oxo-2,3-dihydrobenzo[1,4]oxazin-4-yl)propyl]piperidin-4-yl}-2-phenylacetamide (Lu AE51090): an allosteric muscarinic M1 rec... J Med Chem. 2010 Sep 9;53(17):6386-97. DMM9X0G RU https://pubmed.ncbi.nlm.nih.gov/20684563 DMM9X0G DI DMM9X0G DMM9X0G DN 4-(4-butylpiperidin-1-yl)-1-o-tolylbutan-1-one DMM9X0G MI TTTUMEP DMM9X0G MN Neurotensin receptor type 1 (NTSR1) DMM9X0G MT DTT DMM9X0G MA Inhibitor DMM9X0G RN Discovery of N-{1-[3-(3-oxo-2,3-dihydrobenzo[1,4]oxazin-4-yl)propyl]piperidin-4-yl}-2-phenylacetamide (Lu AE51090): an allosteric muscarinic M1 rec... J Med Chem. 2010 Sep 9;53(17):6386-97. DMM9X0G RU https://pubmed.ncbi.nlm.nih.gov/20684563 DMM9X0G DI DMM9X0G DMM9X0G DN 4-(4-butylpiperidin-1-yl)-1-o-tolylbutan-1-one DMM9X0G MI TTAWNKZ DMM9X0G MN Norepinephrine transporter (NET) DMM9X0G MT DTT DMM9X0G MA Inhibitor DMM9X0G RN Discovery of N-{1-[3-(3-oxo-2,3-dihydrobenzo[1,4]oxazin-4-yl)propyl]piperidin-4-yl}-2-phenylacetamide (Lu AE51090): an allosteric muscarinic M1 rec... J Med Chem. 2010 Sep 9;53(17):6386-97. DMM9X0G RU https://pubmed.ncbi.nlm.nih.gov/20684563 DMM9X0G DI DMM9X0G DMM9X0G DN 4-(4-butylpiperidin-1-yl)-1-o-tolylbutan-1-one DMM9X0G MI TTKWM86 DMM9X0G MN Opioid receptor mu (MOP) DMM9X0G MT DTT DMM9X0G MA Inhibitor DMM9X0G RN Discovery of N-{1-[3-(3-oxo-2,3-dihydrobenzo[1,4]oxazin-4-yl)propyl]piperidin-4-yl}-2-phenylacetamide (Lu AE51090): an allosteric muscarinic M1 rec... J Med Chem. 2010 Sep 9;53(17):6386-97. DMM9X0G RU https://pubmed.ncbi.nlm.nih.gov/20684563 DMM9X0G DI DMM9X0G DMM9X0G DN 4-(4-butylpiperidin-1-yl)-1-o-tolylbutan-1-one DMM9X0G MI TT3ROYC DMM9X0G MN Serotonin transporter (SERT) DMM9X0G MT DTT DMM9X0G MA Inhibitor DMM9X0G RN Discovery of N-{1-[3-(3-oxo-2,3-dihydrobenzo[1,4]oxazin-4-yl)propyl]piperidin-4-yl}-2-phenylacetamide (Lu AE51090): an allosteric muscarinic M1 rec... J Med Chem. 2010 Sep 9;53(17):6386-97. DMM9X0G RU https://pubmed.ncbi.nlm.nih.gov/20684563 DMM9X0G DI DMM9X0G DMM9X0G DN 4-(4-butylpiperidin-1-yl)-1-o-tolylbutan-1-one DMM9X0G MI TTYO0A3 DMM9X0G MN Substance-K receptor (TACR2) DMM9X0G MT DTT DMM9X0G MA Inhibitor DMM9X0G RN Discovery of N-{1-[3-(3-oxo-2,3-dihydrobenzo[1,4]oxazin-4-yl)propyl]piperidin-4-yl}-2-phenylacetamide (Lu AE51090): an allosteric muscarinic M1 rec... J Med Chem. 2010 Sep 9;53(17):6386-97. DMM9X0G RU https://pubmed.ncbi.nlm.nih.gov/20684563 DMM9X0G DI DMM9X0G DMM9X0G DN 4-(4-butylpiperidin-1-yl)-1-o-tolylbutan-1-one DMM9X0G MI TTZPO1L DMM9X0G MN Substance-P receptor (TACR1) DMM9X0G MT DTT DMM9X0G MA Inhibitor DMM9X0G RN Discovery of N-{1-[3-(3-oxo-2,3-dihydrobenzo[1,4]oxazin-4-yl)propyl]piperidin-4-yl}-2-phenylacetamide (Lu AE51090): an allosteric muscarinic M1 rec... J Med Chem. 2010 Sep 9;53(17):6386-97. DMM9X0G RU https://pubmed.ncbi.nlm.nih.gov/20684563 DM14I6C DI DM14I6C DM14I6C DN 4-(4-chloro-2-cyclohexylphenoxy)butanoic acid DM14I6C MI TTQDMX5 DM14I6C MN Prostaglandin D2 receptor 2 (PTGDR2) DM14I6C MT DTT DM14I6C MA Inhibitor DM14I6C RN 2-Cycloalkyl phenoxyacetic acid CRTh2 receptor antagonists. Bioorg Med Chem Lett. 2007 Aug 1;17(15):4347-50. DM14I6C RU https://pubmed.ncbi.nlm.nih.gov/17531480 DMRBEZD DI DMRBEZD DMRBEZD DN 4-(4-chlorobenzyl)-2-allylphthalazin-1(2H)-one DMRBEZD MI TTNGILX DMRBEZD MN Adrenergic receptor alpha-1A (ADRA1A) DMRBEZD MT DTT DMRBEZD MA Inhibitor DMRBEZD RN Vasorelaxant activity of phthalazinones and related compounds. Bioorg Med Chem Lett. 2006 May 15;16(10):2786-90. DMRBEZD RU https://pubmed.ncbi.nlm.nih.gov/16513345 DMRBEZD DI DMRBEZD DMRBEZD DN 4-(4-chlorobenzyl)-2-allylphthalazin-1(2H)-one DMRBEZD MI TT34BHT DMRBEZD MN Adrenergic receptor alpha-1D (ADRA1D) DMRBEZD MT DTT DMRBEZD MA Inhibitor DMRBEZD RN Vasorelaxant activity of phthalazinones and related compounds. Bioorg Med Chem Lett. 2006 May 15;16(10):2786-90. DMRBEZD RU https://pubmed.ncbi.nlm.nih.gov/16513345 DMNYQGV DI DMNYQGV DMNYQGV DN 4-(4-chlorobenzyl)-2-methylphthalazin-1(2H)-one DMNYQGV MI TTNGILX DMNYQGV MN Adrenergic receptor alpha-1A (ADRA1A) DMNYQGV MT DTT DMNYQGV MA Inhibitor DMNYQGV RN Vasorelaxant activity of phthalazinones and related compounds. Bioorg Med Chem Lett. 2006 May 15;16(10):2786-90. DMNYQGV RU https://pubmed.ncbi.nlm.nih.gov/16513345 DMNYQGV DI DMNYQGV DMNYQGV DN 4-(4-chlorobenzyl)-2-methylphthalazin-1(2H)-one DMNYQGV MI TT34BHT DMNYQGV MN Adrenergic receptor alpha-1D (ADRA1D) DMNYQGV MT DTT DMNYQGV MA Inhibitor DMNYQGV RN Vasorelaxant activity of phthalazinones and related compounds. Bioorg Med Chem Lett. 2006 May 15;16(10):2786-90. DMNYQGV RU https://pubmed.ncbi.nlm.nih.gov/16513345 DM9AEF0 DI DM9AEF0 DM9AEF0 DN 4-(4-chlorobenzyl)phthalazin-1(2H)-one DM9AEF0 MI TTNGILX DM9AEF0 MN Adrenergic receptor alpha-1A (ADRA1A) DM9AEF0 MT DTT DM9AEF0 MA Inhibitor DM9AEF0 RN Vasorelaxant activity of phthalazinones and related compounds. Bioorg Med Chem Lett. 2006 May 15;16(10):2786-90. DM9AEF0 RU https://pubmed.ncbi.nlm.nih.gov/16513345 DM9AEF0 DI DM9AEF0 DM9AEF0 DN 4-(4-chlorobenzyl)phthalazin-1(2H)-one DM9AEF0 MI TT34BHT DM9AEF0 MN Adrenergic receptor alpha-1D (ADRA1D) DM9AEF0 MT DTT DM9AEF0 MA Inhibitor DM9AEF0 RN Vasorelaxant activity of phthalazinones and related compounds. Bioorg Med Chem Lett. 2006 May 15;16(10):2786-90. DM9AEF0 RU https://pubmed.ncbi.nlm.nih.gov/16513345 DMENLUP DI DMENLUP DMENLUP DN 4-(4-chlorobenzylthio)-2-aminobutanoic acid DMENLUP MI TTFK1JQ DMENLUP MN Voltage-gated calcium channel alpha-2/delta-1 (CACNA2D1) DMENLUP MT DTT DMENLUP MA Inhibitor DMENLUP RN Structure-activity relationships of alpha-amino acid ligands for the alpha2delta subunit of voltage-gated calcium channels. Bioorg Med Chem Lett. 2006 Mar 1;16(5):1138-41. DMENLUP RU https://pubmed.ncbi.nlm.nih.gov/16380257 DMJI6QH DI DMJI6QH DMJI6QH DN 4-(4-chlorophenyl)-1-pyrid-2-yl-pyrazole DMJI6QH MI TT1MPAY DMJI6QH MN GABA(A) receptor alpha-1 (GABRA1) DMJI6QH MT DTT DMJI6QH MA Inhibitor DMJI6QH RN Synthesis, pharmacology, and structure-activity relationships of novel imidazolones and pyrrolones as modulators of GABAA receptors. J Med Chem. 2006 Mar 23;49(6):1855-66. DMJI6QH RU https://pubmed.ncbi.nlm.nih.gov/16539371 DMJI6QH DI DMJI6QH DMJI6QH DN 4-(4-chlorophenyl)-1-pyrid-2-yl-pyrazole DMJI6QH MI TTZA1NY DMJI6QH MN GABA(A) receptor beta-2 (GABRB2) DMJI6QH MT DTT DMJI6QH MA Inhibitor DMJI6QH RN Synthesis, pharmacology, and structure-activity relationships of novel imidazolones and pyrrolones as modulators of GABAA receptors. J Med Chem. 2006 Mar 23;49(6):1855-66. DMJI6QH RU https://pubmed.ncbi.nlm.nih.gov/16539371 DMJI6QH DI DMJI6QH DMJI6QH DN 4-(4-chlorophenyl)-1-pyrid-2-yl-pyrazole DMJI6QH MI TT06RH5 DMJI6QH MN GABA(A) receptor gamma-2 (GABRG2) DMJI6QH MT DTT DMJI6QH MA Inhibitor DMJI6QH RN Synthesis, pharmacology, and structure-activity relationships of novel imidazolones and pyrrolones as modulators of GABAA receptors. J Med Chem. 2006 Mar 23;49(6):1855-66. DMJI6QH RU https://pubmed.ncbi.nlm.nih.gov/16539371 DMJI6QH DI DMJI6QH DMJI6QH DN 4-(4-chlorophenyl)-1-pyrid-2-yl-pyrazole DMJI6QH MI TTNJYV2 DMJI6QH MN Gamma-aminobutyric acid receptor (GAR) DMJI6QH MT DTT DMJI6QH MA Inhibitor DMJI6QH RN Synthesis, pharmacology, and structure-activity relationships of novel imidazolones and pyrrolones as modulators of GABAA receptors. J Med Chem. 2006 Mar 23;49(6):1855-66. DMJI6QH RU https://pubmed.ncbi.nlm.nih.gov/16539371 DMODVGN DI DMODVGN DMODVGN DN 4-(4-Chlorophenyl)-5-(4-methoxyphenyl)isothiazole DMODVGN MI TT8NGED DMODVGN MN Prostaglandin G/H synthase 1 (COX-1) DMODVGN MT DTT DMODVGN MA Inhibitor DMODVGN RN Diaryl-dithiolanes and -isothiazoles: COX-1/COX-2 and 5-LOX-inhibitory, *OH scavenging and anti-adhesive activities. Bioorg Med Chem. 2009 Jan 15;17(2):558-68. DMODVGN RU https://pubmed.ncbi.nlm.nih.gov/19097798 DMVN7GC DI DMVN7GC DMVN7GC DN 4-(4-chlorophenyl)-5-cyano-2H-1,2,3-triazole DMVN7GC MI TTR5TV4 DMVN7GC MN ERBB2 messenger RNA (HER2 mRNA) DMVN7GC MT DTT DMVN7GC MA Inhibitor DMVN7GC RN Synthesis and biological evaluation of 4-aryl-5-cyano-2H-1,2,3-triazoles as inhibitor of HER2 tyrosine kinase. Bioorg Med Chem. 2007 Feb 1;15(3):1533-8. DMVN7GC RU https://pubmed.ncbi.nlm.nih.gov/17174554 DMZBEYO DI DMZBEYO DMZBEYO DN 4-(4-Chlorophenyl)-5-p-tolyl-1,2-selenazole DMZBEYO MI TT8NGED DMZBEYO MN Prostaglandin G/H synthase 1 (COX-1) DMZBEYO MT DTT DMZBEYO MA Inhibitor DMZBEYO RN Investigations concerning the COX/5-LOX inhibiting and hydroxyl radical scavenging potencies of novel 4,5-diaryl isoselenazoles. Eur J Med Chem. 2008 Jun;43(6):1152-9. DMZBEYO RU https://pubmed.ncbi.nlm.nih.gov/17976864 DMZBEYO DI DMZBEYO DMZBEYO DN 4-(4-Chlorophenyl)-5-p-tolyl-1,2-selenazole DMZBEYO MI TTVKILB DMZBEYO MN Prostaglandin G/H synthase 2 (COX-2) DMZBEYO MT DTT DMZBEYO MA Inhibitor DMZBEYO RN Investigations concerning the COX/5-LOX inhibiting and hydroxyl radical scavenging potencies of novel 4,5-diaryl isoselenazoles. Eur J Med Chem. 2008 Jun;43(6):1152-9. DMZBEYO RU https://pubmed.ncbi.nlm.nih.gov/17976864 DMVDF9Q DI DMVDF9Q DMVDF9Q DN 4-(4-Chlorophenyl)-5-p-tolyl-3H-1,2-dithiol-3-one DMVDF9Q MI TT8NGED DMVDF9Q MN Prostaglandin G/H synthase 1 (COX-1) DMVDF9Q MT DTT DMVDF9Q MA Inhibitor DMVDF9Q RN Diaryl-dithiolanes and -isothiazoles: COX-1/COX-2 and 5-LOX-inhibitory, *OH scavenging and anti-adhesive activities. Bioorg Med Chem. 2009 Jan 15;17(2):558-68. DMVDF9Q RU https://pubmed.ncbi.nlm.nih.gov/19097798 DMMK9RC DI DMMK9RC DMMK9RC DN 4-(4-Chlorophenyl)-5-p-tolylisothiazole DMMK9RC MI TT8NGED DMMK9RC MN Prostaglandin G/H synthase 1 (COX-1) DMMK9RC MT DTT DMMK9RC MA Inhibitor DMMK9RC RN Diaryl-dithiolanes and -isothiazoles: COX-1/COX-2 and 5-LOX-inhibitory, *OH scavenging and anti-adhesive activities. Bioorg Med Chem. 2009 Jan 15;17(2):558-68. DMMK9RC RU https://pubmed.ncbi.nlm.nih.gov/19097798 DM9YRHW DI DM9YRHW DM9YRHW DN 4-(4-chlorophenylthio)-2-(pyridin-2-yl)pyrimidine DM9YRHW MI TTHS256 DM9YRHW MN Metabotropic glutamate receptor 5 (mGluR5) DM9YRHW MT DTT DM9YRHW MA Inhibitor DM9YRHW RN Structure-activity relationship of thiopyrimidines as mGluR5 antagonists. Bioorg Med Chem Lett. 2006 May 1;16(9):2467-9. DM9YRHW RU https://pubmed.ncbi.nlm.nih.gov/16481165 DMNEAJH DI DMNEAJH DMNEAJH DN 4-(4-Cyanophenoxy)-3-pyridinesulfonamide DMNEAJH MI TTHQPL7 DMNEAJH MN Carbonic anhydrase I (CA-I) DMNEAJH MT DTT DMNEAJH MA Inhibitor DMNEAJH RN Carbonic anhydrase inhibitors: synthesis and inhibition of the human cytosolic isozymes I and II and transmembrane isozymes IX, XII (cancer-associa... Eur J Med Chem. 2010 Jun;45(6):2396-404. DMNEAJH RU https://pubmed.ncbi.nlm.nih.gov/20202722 DMNEAJH DI DMNEAJH DMNEAJH DN 4-(4-Cyanophenoxy)-3-pyridinesulfonamide DMNEAJH MI TTANPDJ DMNEAJH MN Carbonic anhydrase II (CA-II) DMNEAJH MT DTT DMNEAJH MA Inhibitor DMNEAJH RN Carbonic anhydrase inhibitors: synthesis and inhibition of the human cytosolic isozymes I and II and transmembrane isozymes IX, XII (cancer-associa... Eur J Med Chem. 2010 Jun;45(6):2396-404. DMNEAJH RU https://pubmed.ncbi.nlm.nih.gov/20202722 DMNEAJH DI DMNEAJH DMNEAJH DN 4-(4-Cyanophenoxy)-3-pyridinesulfonamide DMNEAJH MI TT2LVK8 DMNEAJH MN Carbonic anhydrase IX (CA-IX) DMNEAJH MT DTT DMNEAJH MA Inhibitor DMNEAJH RN Carbonic anhydrase inhibitors: synthesis and inhibition of the human cytosolic isozymes I and II and transmembrane isozymes IX, XII (cancer-associa... Eur J Med Chem. 2010 Jun;45(6):2396-404. DMNEAJH RU https://pubmed.ncbi.nlm.nih.gov/20202722 DMNEAJH DI DMNEAJH DMNEAJH DN 4-(4-Cyanophenoxy)-3-pyridinesulfonamide DMNEAJH MI TTSYM0R DMNEAJH MN Carbonic anhydrase XII (CA-XII) DMNEAJH MT DTT DMNEAJH MA Inhibitor DMNEAJH RN Carbonic anhydrase inhibitors: synthesis and inhibition of the human cytosolic isozymes I and II and transmembrane isozymes IX, XII (cancer-associa... Eur J Med Chem. 2010 Jun;45(6):2396-404. DMNEAJH RU https://pubmed.ncbi.nlm.nih.gov/20202722 DMSYH8R DI DMSYH8R DMSYH8R DN 4-(4-cyclohexylthiosemicarbazono)methyl-phenol DMSYH8R MI TTHM0R1 DMSYH8R MN Steryl-sulfatase (STS) DMSYH8R MT DTT DMSYH8R MA Inhibitor DMSYH8R RN Thiosemicarbazones of formyl benzoic acids as novel potent inhibitors of estrone sulfatase. J Med Chem. 2007 Jul 26;50(15):3661-6. DMSYH8R RU https://pubmed.ncbi.nlm.nih.gov/17580843 DMCDKHJ DI DMCDKHJ DMCDKHJ DN 4-(4-Decyloxy-phenyl)-1,1,1-trifluoro-butan-2-one DMCDKHJ MI TTT1JVS DMCDKHJ MN Cytosolic phospholipase A2 (GIVA cPLA2) DMCDKHJ MT DTT DMCDKHJ MA Inhibitor DMCDKHJ RN Synthesis of polyfluoro ketones for selective inhibition of human phospholipase A2 enzymes. J Med Chem. 2008 Dec 25;51(24):8027-37. DMCDKHJ RU https://pubmed.ncbi.nlm.nih.gov/19053783 DMA6E28 DI DMA6E28 DMA6E28 DN 4'-(4-Fluorobenzensulfonamide)-4-hydroxychalcone DMA6E28 MI TTULVH8 DMA6E28 MN Tyrosinase (TYR) DMA6E28 MT DTT DMA6E28 MA Inhibitor DMA6E28 RN Evaluation of anti-pigmentary effect of synthetic sulfonylamino chalcone. Eur J Med Chem. 2010 May;45(5):2010-7. DMA6E28 RU https://pubmed.ncbi.nlm.nih.gov/20149498 DMW8IN3 DI DMW8IN3 DMW8IN3 DN 4-(4-FLUOROBENZYL)PIPERIDINE DMW8IN3 MI TT8JRS7 DMW8IN3 MN Beta-secretase (BACE) DMW8IN3 MT DTT DMW8IN3 MA Inhibitor DMW8IN3 RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DMW8IN3 RU https://pubmed.ncbi.nlm.nih.gov/10592235 DM4NEOU DI DM4NEOU DM4NEOU DN 4-(4-Fluoro-benzyl)-piperidine hydrochloride DM4NEOU MI TTJQOD7 DM4NEOU MN 5-HT 2A receptor (HTR2A) DM4NEOU MT DTT DM4NEOU MA Inhibitor DM4NEOU RN Ketanserin analogues: structure-affinity relationships for 5-HT2 and 5-HT1C serotonin receptor binding. J Med Chem. 1992 Dec 25;35(26):4903-10. DM4NEOU RU https://pubmed.ncbi.nlm.nih.gov/1479590 DMRJD75 DI DMRJD75 DMRJD75 DN 4-(4-fluoro-benzylideneamino)-benzenesulfonamide DMRJD75 MI TTVKILB DMRJD75 MN Prostaglandin G/H synthase 2 (COX-2) DMRJD75 MT DTT DMRJD75 MA Inhibitor DMRJD75 RN Selective COX-2 inhibitors. Part 2: synthesis and biological evaluation of 4-benzylideneamino- and 4-phenyliminomethyl-benzenesulfonamides. Bioorg Med Chem. 2008 Mar 1;16(5):2697-706. DMRJD75 RU https://pubmed.ncbi.nlm.nih.gov/18063374 DM52NMU DI DM52NMU DM52NMU DN 4-(4'-Fluoro-biphenyl-4-ylmethyl)pyridine DM52NMU MI TTIQUX7 DM52NMU MN Steroid 11-beta-hydroxylase (CYP11B1) DM52NMU MT DTT DM52NMU MA Inhibitor DM52NMU RN Replacement of imidazolyl by pyridyl in biphenylmethylenes results in selective CYP17 and dual CYP17/CYP11B1 inhibitors for the treatment of prosta... J Med Chem. 2010 Aug 12;53(15):5749-58. DM52NMU RU https://pubmed.ncbi.nlm.nih.gov/20684610 DM52NMU DI DM52NMU DM52NMU DN 4-(4'-Fluoro-biphenyl-4-ylmethyl)pyridine DM52NMU MI TTRA5BZ DM52NMU MN Steroid 17-alpha-monooxygenase (S17AH) DM52NMU MT DTT DM52NMU MA Inhibitor DM52NMU RN Replacement of imidazolyl by pyridyl in biphenylmethylenes results in selective CYP17 and dual CYP17/CYP11B1 inhibitors for the treatment of prosta... J Med Chem. 2010 Aug 12;53(15):5749-58. DM52NMU RU https://pubmed.ncbi.nlm.nih.gov/20684610 DMRJLAP DI DMRJLAP DMRJLAP DN 4-(4-Fluorophenoxy)-3-pyridinesulfonamide DMRJLAP MI TTHQPL7 DMRJLAP MN Carbonic anhydrase I (CA-I) DMRJLAP MT DTT DMRJLAP MA Inhibitor DMRJLAP RN Carbonic anhydrase inhibitors: synthesis and inhibition of the human cytosolic isozymes I and II and transmembrane isozymes IX, XII (cancer-associa... Eur J Med Chem. 2010 Jun;45(6):2396-404. DMRJLAP RU https://pubmed.ncbi.nlm.nih.gov/20202722 DMRJLAP DI DMRJLAP DMRJLAP DN 4-(4-Fluorophenoxy)-3-pyridinesulfonamide DMRJLAP MI TTANPDJ DMRJLAP MN Carbonic anhydrase II (CA-II) DMRJLAP MT DTT DMRJLAP MA Inhibitor DMRJLAP RN Carbonic anhydrase inhibitors: synthesis and inhibition of the human cytosolic isozymes I and II and transmembrane isozymes IX, XII (cancer-associa... Eur J Med Chem. 2010 Jun;45(6):2396-404. DMRJLAP RU https://pubmed.ncbi.nlm.nih.gov/20202722 DMRJLAP DI DMRJLAP DMRJLAP DN 4-(4-Fluorophenoxy)-3-pyridinesulfonamide DMRJLAP MI TT2LVK8 DMRJLAP MN Carbonic anhydrase IX (CA-IX) DMRJLAP MT DTT DMRJLAP MA Inhibitor DMRJLAP RN Carbonic anhydrase inhibitors: synthesis and inhibition of the human cytosolic isozymes I and II and transmembrane isozymes IX, XII (cancer-associa... Eur J Med Chem. 2010 Jun;45(6):2396-404. DMRJLAP RU https://pubmed.ncbi.nlm.nih.gov/20202722 DMRJLAP DI DMRJLAP DMRJLAP DN 4-(4-Fluorophenoxy)-3-pyridinesulfonamide DMRJLAP MI TTSYM0R DMRJLAP MN Carbonic anhydrase XII (CA-XII) DMRJLAP MT DTT DMRJLAP MA Inhibitor DMRJLAP RN Carbonic anhydrase inhibitors: synthesis and inhibition of the human cytosolic isozymes I and II and transmembrane isozymes IX, XII (cancer-associa... Eur J Med Chem. 2010 Jun;45(6):2396-404. DMRJLAP RU https://pubmed.ncbi.nlm.nih.gov/20202722 DMK8DCF DI DMK8DCF DMK8DCF DN 4-(4-fluoro-phenyliminomethyl)-benzenesulfonamide DMK8DCF MI TTVKILB DMK8DCF MN Prostaglandin G/H synthase 2 (COX-2) DMK8DCF MT DTT DMK8DCF MA Inhibitor DMK8DCF RN Selective COX-2 inhibitors. Part 2: synthesis and biological evaluation of 4-benzylideneamino- and 4-phenyliminomethyl-benzenesulfonamides. Bioorg Med Chem. 2008 Mar 1;16(5):2697-706. DMK8DCF RU https://pubmed.ncbi.nlm.nih.gov/18063374 DMR9TBW DI DMR9TBW DMR9TBW DN 4-(4-hexylphenyl)-4-oxobut-2-enoic acid DMR9TBW MI TTTSEPU DMR9TBW MN Thyroid hormone receptor alpha (THRA) DMR9TBW MT DTT DMR9TBW MA Inhibitor DMR9TBW RN Inhibitors of the interaction of a thyroid hormone receptor and coactivators: preliminary structure-activity relationships. J Med Chem. 2007 Nov 1;50(22):5269-80. DMR9TBW RU https://pubmed.ncbi.nlm.nih.gov/17918822 DMR9TBW DI DMR9TBW DMR9TBW DN 4-(4-hexylphenyl)-4-oxobut-2-enoic acid DMR9TBW MI TTGER3L DMR9TBW MN Thyroid hormone receptor beta (THRB) DMR9TBW MT DTT DMR9TBW MA Inhibitor DMR9TBW RN Inhibitors of the interaction of a thyroid hormone receptor and coactivators: preliminary structure-activity relationships. J Med Chem. 2007 Nov 1;50(22):5269-80. DMR9TBW RU https://pubmed.ncbi.nlm.nih.gov/17918822 DMNY0I5 DI DMNY0I5 DMNY0I5 DN 4-(4-hydroxy-benzylideneamino)-benzenesulfonamide DMNY0I5 MI TTANPDJ DMNY0I5 MN Carbonic anhydrase II (CA-II) DMNY0I5 MT DTT DMNY0I5 MA Inhibitor DMNY0I5 RN Carbonic anhydrase II-induced selection of inhibitors from a dynamic combinatorial library of Schiff's bases. Bioorg Med Chem Lett. 2009 Nov 1;19(21):6014-7. DMNY0I5 RU https://pubmed.ncbi.nlm.nih.gov/19796939 DMNY0I5 DI DMNY0I5 DMNY0I5 DN 4-(4-hydroxy-benzylideneamino)-benzenesulfonamide DMNY0I5 MI TTVKILB DMNY0I5 MN Prostaglandin G/H synthase 2 (COX-2) DMNY0I5 MT DTT DMNY0I5 MA Inhibitor DMNY0I5 RN Selective COX-2 inhibitors. Part 2: synthesis and biological evaluation of 4-benzylideneamino- and 4-phenyliminomethyl-benzenesulfonamides. Bioorg Med Chem. 2008 Mar 1;16(5):2697-706. DMNY0I5 RU https://pubmed.ncbi.nlm.nih.gov/18063374 DML357W DI DML357W DML357W DN 4-(4-hydroxybenzylideneamino)benzoic acid DML357W MI TTANPDJ DML357W MN Carbonic anhydrase II (CA-II) DML357W MT DTT DML357W MA Inhibitor DML357W RN Carbonic anhydrase II-induced selection of inhibitors from a dynamic combinatorial library of Schiff's bases. Bioorg Med Chem Lett. 2009 Nov 1;19(21):6014-7. DML357W RU https://pubmed.ncbi.nlm.nih.gov/19796939 DMZT6HL DI DMZT6HL DMZT6HL DN 4-(4-HYDROXYPHENYL)-1-NAPHTHALDEHYDE OXIME DMZT6HL MI TTOM3J0 DMZT6HL MN Estrogen receptor beta (ESR2) DMZT6HL MT DTT DMZT6HL MA Inhibitor DMZT6HL RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DMZT6HL RU https://pubmed.ncbi.nlm.nih.gov/10592235 DMC9Z45 DI DMC9Z45 DMC9Z45 DN 4-(4-Isopropyl-morpholin-2-yl)-benzene-1,2-diol DMC9Z45 MI TTNGILX DMC9Z45 MN Adrenergic receptor alpha-1A (ADRA1A) DMC9Z45 MT DTT DMC9Z45 MA Inhibitor DMC9Z45 RN Conformational effects on the activity of drugs. 13. A revision of previously proposed models for the activation of alpha- and beta-adrenergic rece... J Med Chem. 1992 Mar 20;35(6):1009-18. DMC9Z45 RU https://pubmed.ncbi.nlm.nih.gov/1313109 DMC9Z45 DI DMC9Z45 DMC9Z45 DN 4-(4-Isopropyl-morpholin-2-yl)-benzene-1,2-diol DMC9Z45 MI TTBRKXS DMC9Z45 MN Adrenergic receptor alpha-1B (ADRA1B) DMC9Z45 MT DTT DMC9Z45 MA Inhibitor DMC9Z45 RN Conformational effects on the activity of drugs. 13. A revision of previously proposed models for the activation of alpha- and beta-adrenergic rece... J Med Chem. 1992 Mar 20;35(6):1009-18. DMC9Z45 RU https://pubmed.ncbi.nlm.nih.gov/1313109 DMC9Z45 DI DMC9Z45 DMC9Z45 DN 4-(4-Isopropyl-morpholin-2-yl)-benzene-1,2-diol DMC9Z45 MI TT34BHT DMC9Z45 MN Adrenergic receptor alpha-1D (ADRA1D) DMC9Z45 MT DTT DMC9Z45 MA Inhibitor DMC9Z45 RN Conformational effects on the activity of drugs. 13. A revision of previously proposed models for the activation of alpha- and beta-adrenergic rece... J Med Chem. 1992 Mar 20;35(6):1009-18. DMC9Z45 RU https://pubmed.ncbi.nlm.nih.gov/1313109 DMRGM21 DI DMRGM21 DMRGM21 DN 4-(4-isopropylphenyl)-5-cyano-2H-1,2,3-triazole DMRGM21 MI TTR5TV4 DMRGM21 MN ERBB2 messenger RNA (HER2 mRNA) DMRGM21 MT DTT DMRGM21 MA Inhibitor DMRGM21 RN Synthesis and biological evaluation of 4-aryl-5-cyano-2H-1,2,3-triazoles as inhibitor of HER2 tyrosine kinase. Bioorg Med Chem. 2007 Feb 1;15(3):1533-8. DMRGM21 RU https://pubmed.ncbi.nlm.nih.gov/17174554 DMA7LEO DI DMA7LEO DMA7LEO DN 4-(4-methoxy-1H-indol-1-ylsulfonyl)benzenamine DMA7LEO MI TTJS8PY DMA7LEO MN 5-HT 6 receptor (HTR6) DMA7LEO MT DTT DMA7LEO MA Inhibitor DMA7LEO RN Binding of methoxy-substituted N1-benzenesulfonylindole analogs at human 5-HT6 serotonin receptors. Bioorg Med Chem Lett. 2006 Jul 15;16(14):3793-6. DMA7LEO RU https://pubmed.ncbi.nlm.nih.gov/16709453 DM5PTB9 DI DM5PTB9 DM5PTB9 DN 4-(4-Methoxy-benzenesulfonyl)-butane-2-thiol DM5PTB9 MI TTMX39J DM5PTB9 MN Matrix metalloproteinase-1 (MMP-1) DM5PTB9 MT DTT DM5PTB9 MA Inhibitor DM5PTB9 RN Discovery of a novel series of selective MMP inhibitors: identification of the gamma-sulfone-thiols. Bioorg Med Chem Lett. 1999 Apr 5;9(7):943-8. DM5PTB9 RU https://pubmed.ncbi.nlm.nih.gov/10230616 DM5PTB9 DI DM5PTB9 DM5PTB9 DN 4-(4-Methoxy-benzenesulfonyl)-butane-2-thiol DM5PTB9 MI TTHY57M DM5PTB9 MN Matrix metalloproteinase-13 (MMP-13) DM5PTB9 MT DTT DM5PTB9 MA Inhibitor DM5PTB9 RN Discovery of a novel series of selective MMP inhibitors: identification of the gamma-sulfone-thiols. Bioorg Med Chem Lett. 1999 Apr 5;9(7):943-8. DM5PTB9 RU https://pubmed.ncbi.nlm.nih.gov/10230616 DM2OR8E DI DM2OR8E DM2OR8E DN 4-(4-methoxy-benzylideneamino)-benzenesulfonamide DM2OR8E MI TTVKILB DM2OR8E MN Prostaglandin G/H synthase 2 (COX-2) DM2OR8E MT DTT DM2OR8E MA Inhibitor DM2OR8E RN Selective COX-2 inhibitors. Part 2: synthesis and biological evaluation of 4-benzylideneamino- and 4-phenyliminomethyl-benzenesulfonamides. Bioorg Med Chem. 2008 Mar 1;16(5):2697-706. DM2OR8E RU https://pubmed.ncbi.nlm.nih.gov/18063374 DMZSQ04 DI DMZSQ04 DMZSQ04 DN 4-(4-methyl-benzylideneamino)-benzenesulfonamide DMZSQ04 MI TTVKILB DMZSQ04 MN Prostaglandin G/H synthase 2 (COX-2) DMZSQ04 MT DTT DMZSQ04 MA Inhibitor DMZSQ04 RN Selective COX-2 inhibitors. Part 2: synthesis and biological evaluation of 4-benzylideneamino- and 4-phenyliminomethyl-benzenesulfonamides. Bioorg Med Chem. 2008 Mar 1;16(5):2697-706. DMZSQ04 RU https://pubmed.ncbi.nlm.nih.gov/18063374 DMYZHXR DI DMYZHXR DMYZHXR DN 4-(4-Methyl-indan-1-yl)-1H-imidazole DMYZHXR MI TTNGILX DMYZHXR MN Adrenergic receptor alpha-1A (ADRA1A) DMYZHXR MT DTT DMYZHXR MA Inhibitor DMYZHXR RN Medetomidine analogs as alpha 2-adrenergic ligands. 3. Synthesis and biological evaluation of a new series of medetomidine analogs and their potent... J Med Chem. 1997 Sep 12;40(19):3014-24. DMYZHXR RU https://pubmed.ncbi.nlm.nih.gov/9301663 DMYZHXR DI DMYZHXR DMYZHXR DN 4-(4-Methyl-indan-1-yl)-1H-imidazole DMYZHXR MI TTBRKXS DMYZHXR MN Adrenergic receptor alpha-1B (ADRA1B) DMYZHXR MT DTT DMYZHXR MA Inhibitor DMYZHXR RN Medetomidine analogs as alpha 2-adrenergic ligands. 3. Synthesis and biological evaluation of a new series of medetomidine analogs and their potent... J Med Chem. 1997 Sep 12;40(19):3014-24. DMYZHXR RU https://pubmed.ncbi.nlm.nih.gov/9301663 DMYZHXR DI DMYZHXR DMYZHXR DN 4-(4-Methyl-indan-1-yl)-1H-imidazole DMYZHXR MI TT34BHT DMYZHXR MN Adrenergic receptor alpha-1D (ADRA1D) DMYZHXR MT DTT DMYZHXR MA Inhibitor DMYZHXR RN Medetomidine analogs as alpha 2-adrenergic ligands. 3. Synthesis and biological evaluation of a new series of medetomidine analogs and their potent... J Med Chem. 1997 Sep 12;40(19):3014-24. DMYZHXR RU https://pubmed.ncbi.nlm.nih.gov/9301663 DMYZHXR DI DMYZHXR DMYZHXR DN 4-(4-Methyl-indan-1-yl)-1H-imidazole DMYZHXR MI TTWG9A4 DMYZHXR MN Adrenergic receptor alpha-2A (ADRA2A) DMYZHXR MT DTT DMYZHXR MA Inhibitor DMYZHXR RN Medetomidine analogs as alpha 2-adrenergic ligands. 3. Synthesis and biological evaluation of a new series of medetomidine analogs and their potent... J Med Chem. 1997 Sep 12;40(19):3014-24. DMYZHXR RU https://pubmed.ncbi.nlm.nih.gov/9301663 DMYZHXR DI DMYZHXR DMYZHXR DN 4-(4-Methyl-indan-1-yl)-1H-imidazole DMYZHXR MI TTWM4TY DMYZHXR MN Adrenergic receptor alpha-2B (ADRA2B) DMYZHXR MT DTT DMYZHXR MA Inhibitor DMYZHXR RN Medetomidine analogs as alpha 2-adrenergic ligands. 3. Synthesis and biological evaluation of a new series of medetomidine analogs and their potent... J Med Chem. 1997 Sep 12;40(19):3014-24. DMYZHXR RU https://pubmed.ncbi.nlm.nih.gov/9301663 DMYZHXR DI DMYZHXR DMYZHXR DN 4-(4-Methyl-indan-1-yl)-1H-imidazole DMYZHXR MI TT2NUT5 DMYZHXR MN Adrenergic receptor alpha-2C (ADRA2C) DMYZHXR MT DTT DMYZHXR MA Inhibitor DMYZHXR RN Medetomidine analogs as alpha 2-adrenergic ligands. 3. Synthesis and biological evaluation of a new series of medetomidine analogs and their potent... J Med Chem. 1997 Sep 12;40(19):3014-24. DMYZHXR RU https://pubmed.ncbi.nlm.nih.gov/9301663 DMV0S4U DI DMV0S4U DMV0S4U DN 4-(4-methyl-phenyliminomethyl)-benzenesulfonamide DMV0S4U MI TTVKILB DMV0S4U MN Prostaglandin G/H synthase 2 (COX-2) DMV0S4U MT DTT DMV0S4U MA Inhibitor DMV0S4U RN Selective COX-2 inhibitors. Part 2: synthesis and biological evaluation of 4-benzylideneamino- and 4-phenyliminomethyl-benzenesulfonamides. Bioorg Med Chem. 2008 Mar 1;16(5):2697-706. DMV0S4U RU https://pubmed.ncbi.nlm.nih.gov/18063374 DMS74F2 DI DMS74F2 DMS74F2 DN 4-(4-Morpholin-4-yl-butyl)-2H-phthalazin-1-one DMS74F2 MI TTVDSZ0 DMS74F2 MN Poly [ADP-ribose] polymerase 1 (PARP1) DMS74F2 MT DTT DMS74F2 MA Inhibitor DMS74F2 RN 4-Phenyl-1,2,3,6-tetrahydropyridine, an excellent fragment to improve the potency of PARP-1 inhibitors. Bioorg Med Chem Lett. 2005 Oct 1;15(19):4221-5. DMS74F2 RU https://pubmed.ncbi.nlm.nih.gov/16098744 DM3KCL1 DI DM3KCL1 DM3KCL1 DN 4-(4-m-Tolylamino-phthalazin-1-yl)-benzamide DM3KCL1 MI TTUTJGQ DM3KCL1 MN Vascular endothelial growth factor receptor 2 (KDR) DM3KCL1 MT DTT DM3KCL1 MA Inhibitor DM3KCL1 RN Arylphthalazines: identification of a new phthalazine chemotype as inhibitors of VEGFR kinase. Bioorg Med Chem Lett. 2005 Nov 1;15(21):4696-8. DM3KCL1 RU https://pubmed.ncbi.nlm.nih.gov/16143524 DMHB1N6 DI DMHB1N6 DMHB1N6 DN 4'-(4-Nitrobenzensulfonamide)-4-hydroxychalcone DMHB1N6 MI TTULVH8 DMHB1N6 MN Tyrosinase (TYR) DMHB1N6 MT DTT DMHB1N6 MA Inhibitor DMHB1N6 RN Evaluation of anti-pigmentary effect of synthetic sulfonylamino chalcone. Eur J Med Chem. 2010 May;45(5):2010-7. DMHB1N6 RU https://pubmed.ncbi.nlm.nih.gov/20149498 DMM86YK DI DMM86YK DMM86YK DN 4-(4-nitro-benzylideneamino)-benzenesulfonamide DMM86YK MI TTVKILB DMM86YK MN Prostaglandin G/H synthase 2 (COX-2) DMM86YK MT DTT DMM86YK MA Inhibitor DMM86YK RN Selective COX-2 inhibitors. Part 2: synthesis and biological evaluation of 4-benzylideneamino- and 4-phenyliminomethyl-benzenesulfonamides. Bioorg Med Chem. 2008 Mar 1;16(5):2697-706. DMM86YK RU https://pubmed.ncbi.nlm.nih.gov/18063374 DMGVNE3 DI DMGVNE3 DMGVNE3 DN 4-(4'-N-Methylphenyl)diazenylbenzenesulfonamide DMGVNE3 MI TT2LVK8 DMGVNE3 MN Carbonic anhydrase IX (CA-IX) DMGVNE3 MT DTT DMGVNE3 MA Inhibitor DMGVNE3 RN Carbonic anhydrase inhibitors. Diazenylbenzenesulfonamides are potent and selective inhibitors of the tumor-associated isozymes IX and XII over the... Bioorg Med Chem. 2009 Oct 15;17(20):7093-9. DMGVNE3 RU https://pubmed.ncbi.nlm.nih.gov/19773173 DMGVNE3 DI DMGVNE3 DMGVNE3 DN 4-(4'-N-Methylphenyl)diazenylbenzenesulfonamide DMGVNE3 MI TTSYM0R DMGVNE3 MN Carbonic anhydrase XII (CA-XII) DMGVNE3 MT DTT DMGVNE3 MA Inhibitor DMGVNE3 RN Carbonic anhydrase inhibitors. Diazenylbenzenesulfonamides are potent and selective inhibitors of the tumor-associated isozymes IX and XII over the... Bioorg Med Chem. 2009 Oct 15;17(20):7093-9. DMGVNE3 RU https://pubmed.ncbi.nlm.nih.gov/19773173 DMOHB6U DI DMOHB6U DMOHB6U DN 4-(4-phenoxybenzoyl)benzoic acid DMOHB6U MI TTTU72V DMOHB6U MN Steroid 5-alpha-reductase 1 (SRD5A1) DMOHB6U MT DTT DMOHB6U MA Inhibitor DMOHB6U RN Novel 5alpha-reductase inhibitors: synthesis, structure-activity studies, and pharmacokinetic profile of phenoxybenzoylphenyl acetic acids. J Med Chem. 2006 Jan 26;49(2):748-59. DMOHB6U RU https://pubmed.ncbi.nlm.nih.gov/16420060 DMOHB6U DI DMOHB6U DMOHB6U DN 4-(4-phenoxybenzoyl)benzoic acid DMOHB6U MI TTT02K8 DMOHB6U MN Steroid 5-alpha-reductase 2 (SRD5A2) DMOHB6U MT DTT DMOHB6U MA Inhibitor DMOHB6U RN Novel 5alpha-reductase inhibitors: synthesis, structure-activity studies, and pharmacokinetic profile of phenoxybenzoylphenyl acetic acids. J Med Chem. 2006 Jan 26;49(2):748-59. DMOHB6U RU https://pubmed.ncbi.nlm.nih.gov/16420060 DMQ0JWZ DI DMQ0JWZ DMQ0JWZ DN 4-(4-phenoxybenzoyl)phenylacetic acid DMQ0JWZ MI TTT02K8 DMQ0JWZ MN Steroid 5-alpha-reductase 2 (SRD5A2) DMQ0JWZ MT DTT DMQ0JWZ MA Inhibitor DMQ0JWZ RN Novel 5alpha-reductase inhibitors: synthesis, structure-activity studies, and pharmacokinetic profile of phenoxybenzoylphenyl acetic acids. J Med Chem. 2006 Jan 26;49(2):748-59. DMQ0JWZ RU https://pubmed.ncbi.nlm.nih.gov/16420060 DMKMH5L DI DMKMH5L DMKMH5L DN 4-(4-phenoxybutoxy)-7H-furo[3,2-g]chromen-7-one DMKMH5L MI TTMNI76 DMKMH5L MN Calcium-activated potassium channel (KCN) DMKMH5L MT DTT DMKMH5L MA Inhibitor DMKMH5L RN Inhibitors of potassium channels KV1.3 and IK-1 as immunosuppressants. Bioorg Med Chem Lett. 2009 Apr 15;19(8):2299-304. DMKMH5L RU https://pubmed.ncbi.nlm.nih.gov/19282171 DMKMH5L DI DMKMH5L DMKMH5L DN 4-(4-phenoxybutoxy)-7H-furo[3,2-g]chromen-7-one DMKMH5L MI TTY3UE6 DMKMH5L MN Voltage-gated potassium channel Kv1.3 (KCNA3) DMKMH5L MT DTT DMKMH5L MA Inhibitor DMKMH5L RN Design of PAP-1, a selective small molecule Kv1.3 blocker, for the suppression of effector memory T cells in autoimmune diseases. Mol Pharmacol. 2005 Nov;68(5):1254-70. DMKMH5L RU https://pubmed.ncbi.nlm.nih.gov/16099841 DMKMH5L DI DMKMH5L DMKMH5L DN 4-(4-phenoxybutoxy)-7H-furo[3,2-g]chromen-7-one DMKMH5L MI TTW0CMT DMKMH5L MN Voltage-gated potassium channel Kv1.5 (KCNA5) DMKMH5L MT DTT DMKMH5L MA Inhibitor DMKMH5L RN Substituted N-{3-[(1,1-dioxido-1,2-benzothiazol-3-yl)(phenyl)amino]propyl}benzamide analogs as potent Kv1.3 ion channel blockers. Part 2. Bioorg Med Chem Lett. 2010 Dec 1;20(23):6989-92. DMKMH5L RU https://pubmed.ncbi.nlm.nih.gov/20974533 DMBZHUA DI DMBZHUA DMBZHUA DN 4-(4-propoxyphenoxy)phenol DMBZHUA MI TTXZEAJ DMBZHUA MN Leukotriene A-4 hydrolase (LTA4H) DMBZHUA MT DTT DMBZHUA MA Inhibitor DMBZHUA RN Activation and inhibition of leukotriene A4 hydrolase aminopeptidase activity by diphenyl ether and derivatives. Bioorg Med Chem Lett. 2008 Dec 15;18(24):6549-52. DMBZHUA RU https://pubmed.ncbi.nlm.nih.gov/18952425 DM6ESXB DI DM6ESXB DM6ESXB DN 4-(4-p-Tolylamino-phthalazin-1-yl)-benzamide DM6ESXB MI TTUTJGQ DM6ESXB MN Vascular endothelial growth factor receptor 2 (KDR) DM6ESXB MT DTT DM6ESXB MA Inhibitor DM6ESXB RN Arylphthalazines: identification of a new phthalazine chemotype as inhibitors of VEGFR kinase. Bioorg Med Chem Lett. 2005 Nov 1;15(21):4696-8. DM6ESXB RU https://pubmed.ncbi.nlm.nih.gov/16143524 DMFLH2G DI DMFLH2G DMFLH2G DN 4-(4-tert-butylbenzylideneamino)benzoic acid DMFLH2G MI TTANPDJ DMFLH2G MN Carbonic anhydrase II (CA-II) DMFLH2G MT DTT DMFLH2G MA Inhibitor DMFLH2G RN Carbonic anhydrase II-induced selection of inhibitors from a dynamic combinatorial library of Schiff's bases. Bioorg Med Chem Lett. 2009 Nov 1;19(21):6014-7. DMFLH2G RU https://pubmed.ncbi.nlm.nih.gov/19796939 DMG6DV9 DI DMG6DV9 DMG6DV9 DN 4-(4-tert-butylbenzylthio)-2-aminobutanoic acid DMG6DV9 MI TTFK1JQ DMG6DV9 MN Voltage-gated calcium channel alpha-2/delta-1 (CACNA2D1) DMG6DV9 MT DTT DMG6DV9 MA Inhibitor DMG6DV9 RN Structure-activity relationships of alpha-amino acid ligands for the alpha2delta subunit of voltage-gated calcium channels. Bioorg Med Chem Lett. 2006 Mar 1;16(5):1138-41. DMG6DV9 RU https://pubmed.ncbi.nlm.nih.gov/16380257 DMGHVW7 DI DMGHVW7 DMGHVW7 DN 4-(5-(4-(methylamino)phenyl)thiophen-2-yl)phenol DMGHVW7 MI TTE4KHA DMGHVW7 MN Amyloid beta A4 protein (APP) DMGHVW7 MT DTT DMGHVW7 MA Inhibitor DMGHVW7 RN Design, synthesis, and structure-activity relationship of novel thiophene derivatives for beta-amyloid plaque imaging. Bioorg Med Chem Lett. 2006 Mar 1;16(5):1350-2. DMGHVW7 RU https://pubmed.ncbi.nlm.nih.gov/16325402 DMOGMJ9 DI DMOGMJ9 DMOGMJ9 DN 4-(5-(4-aminophenyl)thiophen-2-yl)benzenamine DMOGMJ9 MI TTE4KHA DMOGMJ9 MN Amyloid beta A4 protein (APP) DMOGMJ9 MT DTT DMOGMJ9 MA Inhibitor DMOGMJ9 RN Design, synthesis, and structure-activity relationship of novel thiophene derivatives for beta-amyloid plaque imaging. Bioorg Med Chem Lett. 2006 Mar 1;16(5):1350-2. DMOGMJ9 RU https://pubmed.ncbi.nlm.nih.gov/16325402 DM1UX89 DI DM1UX89 DM1UX89 DN 4-(5-(4-aminophenyl)thiophen-2-yl)phenol DM1UX89 MI TTE4KHA DM1UX89 MN Amyloid beta A4 protein (APP) DM1UX89 MT DTT DM1UX89 MA Inhibitor DM1UX89 RN Design, synthesis, and structure-activity relationship of novel thiophene derivatives for beta-amyloid plaque imaging. Bioorg Med Chem Lett. 2006 Mar 1;16(5):1350-2. DM1UX89 RU https://pubmed.ncbi.nlm.nih.gov/16325402 DMK1ZF2 DI DMK1ZF2 DMK1ZF2 DN 4-(5-(4-Hydroxyphenyl)isothiazol-4-yl)phenol DMK1ZF2 MI TT8NGED DMK1ZF2 MN Prostaglandin G/H synthase 1 (COX-1) DMK1ZF2 MT DTT DMK1ZF2 MA Inhibitor DMK1ZF2 RN Diaryl-dithiolanes and -isothiazoles: COX-1/COX-2 and 5-LOX-inhibitory, *OH scavenging and anti-adhesive activities. Bioorg Med Chem. 2009 Jan 15;17(2):558-68. DMK1ZF2 RU https://pubmed.ncbi.nlm.nih.gov/19097798 DMO9YH0 DI DMO9YH0 DMO9YH0 DN 4-(5-(4-methoxyphenyl)thiophen-2-yl)benzenamine DMO9YH0 MI TTE4KHA DMO9YH0 MN Amyloid beta A4 protein (APP) DMO9YH0 MT DTT DMO9YH0 MA Inhibitor DMO9YH0 RN Design, synthesis, and structure-activity relationship of novel thiophene derivatives for beta-amyloid plaque imaging. Bioorg Med Chem Lett. 2006 Mar 1;16(5):1350-2. DMO9YH0 RU https://pubmed.ncbi.nlm.nih.gov/16325402 DMCNLBZ DI DMCNLBZ DMCNLBZ DN 4-(5-(4-methoxyphenyl)thiophen-2-yl)phenol DMCNLBZ MI TTE4KHA DMCNLBZ MN Amyloid beta A4 protein (APP) DMCNLBZ MT DTT DMCNLBZ MA Inhibitor DMCNLBZ RN Design, synthesis, and structure-activity relationship of novel thiophene derivatives for beta-amyloid plaque imaging. Bioorg Med Chem Lett. 2006 Mar 1;16(5):1350-2. DMCNLBZ RU https://pubmed.ncbi.nlm.nih.gov/16325402 DMJKUQI DI DMJKUQI DMJKUQI DN 4-(5-bromo-1H-indol-3-yl)pyrimidin-2-amine DMJKUQI MI TTRSMW9 DMJKUQI MN Glycogen synthase kinase-3 beta (GSK-3B) DMJKUQI MT DTT DMJKUQI MA Inhibitor DMJKUQI RN Fragment and knowledge-based design of selective GSK-3beta inhibitors using virtual screening models. Eur J Med Chem. 2009 Jun;44(6):2361-71. DMJKUQI RU https://pubmed.ncbi.nlm.nih.gov/18929433 DMLSGU1 DI DMLSGU1 DMLSGU1 DN 4-(5-Bromoindole-3-yl)-6,7-dimethoxyquinazoline DMLSGU1 MI TTGKNB4 DMLSGU1 MN Epidermal growth factor receptor (EGFR) DMLSGU1 MT DTT DMLSGU1 MA Inhibitor DMLSGU1 RN Syntheses of 4-(indole-3-yl)quinazolines: a new class of epidermal growth factor receptor tyrosine kinase inhibitors. Eur J Med Chem. 2008 Jul;43(7):1478-88. DMLSGU1 RU https://pubmed.ncbi.nlm.nih.gov/17981366 DMDYBIC DI DMDYBIC DMDYBIC DN 4'-(5-Chloro-2-thienyl)biphenyl-3-ol DMDYBIC MI TTIWB6L DMDYBIC MN Estradiol 17 beta-dehydrogenase 1 (17-beta-HSD1) DMDYBIC MT DTT DMDYBIC MA Inhibitor DMDYBIC RN Novel estrone mimetics with high 17beta-HSD1 inhibitory activity. Bioorg Med Chem. 2010 May 15;18(10):3494-505. DMDYBIC RU https://pubmed.ncbi.nlm.nih.gov/20413314 DM1EANV DI DM1EANV DM1EANV DN 4-(5-Hydroxy-benzooxazol-2-yl)-benzene-1,3-diol DM1EANV MI TTZAYWL DM1EANV MN Estrogen receptor (ESR) DM1EANV MT DTT DM1EANV MA Inhibitor DM1EANV RN Design and synthesis of aryl diphenolic azoles as potent and selective estrogen receptor-beta ligands. J Med Chem. 2004 Oct 7;47(21):5021-40. DM1EANV RU https://pubmed.ncbi.nlm.nih.gov/15456246 DM1EANV DI DM1EANV DM1EANV DN 4-(5-Hydroxy-benzooxazol-2-yl)-benzene-1,3-diol DM1EANV MI TTOM3J0 DM1EANV MN Estrogen receptor beta (ESR2) DM1EANV MT DTT DM1EANV MA Inhibitor DM1EANV RN Design and synthesis of aryl diphenolic azoles as potent and selective estrogen receptor-beta ligands. J Med Chem. 2004 Oct 7;47(21):5021-40. DM1EANV RU https://pubmed.ncbi.nlm.nih.gov/15456246 DMIWT60 DI DMIWT60 DMIWT60 DN 4-(5-Methoxy-benzoimidazol-1-yl)-phenylamine DMIWT60 MI TT8FYO9 DMIWT60 MN Platelet-derived growth factor receptor alpha (PDGFRA) DMIWT60 MT DTT DMIWT60 MA Inhibitor DMIWT60 RN Structure-activity relationships for 5-substituted 1-phenylbenzimidazoles as selective inhibitors of the platelet-derived growth factor receptor. J Med Chem. 1999 Jul 1;42(13):2373-82. DMIWT60 RU https://pubmed.ncbi.nlm.nih.gov/10395478 DMIWT60 DI DMIWT60 DMIWT60 DN 4-(5-Methoxy-benzoimidazol-1-yl)-phenylamine DMIWT60 MI TTI7421 DMIWT60 MN Platelet-derived growth factor receptor beta (PDGFRB) DMIWT60 MT DTT DMIWT60 MA Inhibitor DMIWT60 RN Structure-activity relationships for 5-substituted 1-phenylbenzimidazoles as selective inhibitors of the platelet-derived growth factor receptor. J Med Chem. 1999 Jul 1;42(13):2373-82. DMIWT60 RU https://pubmed.ncbi.nlm.nih.gov/10395478 DMKT20Q DI DMKT20Q DMKT20Q DN 4-(5-Methyl-2-pirazolino)-3-pyridinesulfonamide DMKT20Q MI TTHQPL7 DMKT20Q MN Carbonic anhydrase I (CA-I) DMKT20Q MT DTT DMKT20Q MA Inhibitor DMKT20Q RN Carbonic anhydrase inhibitors: synthesis and inhibition of the human cytosolic isozymes I and II and transmembrane isozymes IX, XII (cancer-associa... Eur J Med Chem. 2010 Jun;45(6):2396-404. DMKT20Q RU https://pubmed.ncbi.nlm.nih.gov/20202722 DMKT20Q DI DMKT20Q DMKT20Q DN 4-(5-Methyl-2-pirazolino)-3-pyridinesulfonamide DMKT20Q MI TTANPDJ DMKT20Q MN Carbonic anhydrase II (CA-II) DMKT20Q MT DTT DMKT20Q MA Inhibitor DMKT20Q RN Carbonic anhydrase inhibitors: synthesis and inhibition of the human cytosolic isozymes I and II and transmembrane isozymes IX, XII (cancer-associa... Eur J Med Chem. 2010 Jun;45(6):2396-404. DMKT20Q RU https://pubmed.ncbi.nlm.nih.gov/20202722 DMKT20Q DI DMKT20Q DMKT20Q DN 4-(5-Methyl-2-pirazolino)-3-pyridinesulfonamide DMKT20Q MI TT2LVK8 DMKT20Q MN Carbonic anhydrase IX (CA-IX) DMKT20Q MT DTT DMKT20Q MA Inhibitor DMKT20Q RN Carbonic anhydrase inhibitors: synthesis and inhibition of the human cytosolic isozymes I and II and transmembrane isozymes IX, XII (cancer-associa... Eur J Med Chem. 2010 Jun;45(6):2396-404. DMKT20Q RU https://pubmed.ncbi.nlm.nih.gov/20202722 DMKT20Q DI DMKT20Q DMKT20Q DN 4-(5-Methyl-2-pirazolino)-3-pyridinesulfonamide DMKT20Q MI TTSYM0R DMKT20Q MN Carbonic anhydrase XII (CA-XII) DMKT20Q MT DTT DMKT20Q MA Inhibitor DMKT20Q RN Carbonic anhydrase inhibitors: synthesis and inhibition of the human cytosolic isozymes I and II and transmembrane isozymes IX, XII (cancer-associa... Eur J Med Chem. 2010 Jun;45(6):2396-404. DMKT20Q RU https://pubmed.ncbi.nlm.nih.gov/20202722 DMKT20Q DI DMKT20Q DMKT20Q DN 4-(5-Methyl-2-pirazolino)-3-pyridinesulfonamide DMKT20Q MI TTEYTKG DMKT20Q MN Carbonic anhydrase XIV (CA-XIV) DMKT20Q MT DTT DMKT20Q MA Inhibitor DMKT20Q RN Carbonic anhydrase inhibitors: synthesis and inhibition of the human cytosolic isozymes I and II and transmembrane isozymes IX, XII (cancer-associa... Eur J Med Chem. 2010 Jun;45(6):2396-404. DMKT20Q RU https://pubmed.ncbi.nlm.nih.gov/20202722 DMXHIK5 DI DMXHIK5 DMXHIK5 DN 4-(5-Morpholin-4-yl-pentyl)-2H-phthalazin-1-one DMXHIK5 MI TTVDSZ0 DMXHIK5 MN Poly [ADP-ribose] polymerase 1 (PARP1) DMXHIK5 MT DTT DMXHIK5 MA Inhibitor DMXHIK5 RN 4-Phenyl-1,2,3,6-tetrahydropyridine, an excellent fragment to improve the potency of PARP-1 inhibitors. Bioorg Med Chem Lett. 2005 Oct 1;15(19):4221-5. DMXHIK5 RU https://pubmed.ncbi.nlm.nih.gov/16098744 DMUHQ0J DI DMUHQ0J DMUHQ0J DN 4-(5-Nitro-indol-1-ylmethyl)-benzamidine DMUHQ0J MI TT2WR1T DMUHQ0J MN Cationic trypsinogen (PRSS1) DMUHQ0J MT DTT DMUHQ0J MA Inhibitor DMUHQ0J RN Aromatic amidines: comparison of their ability to block respiratory syncytial virus induced cell fusion and to inhibit plasmin, urokinase, thrombin... J Med Chem. 1983 Feb;26(2):294-8. DMUHQ0J RU https://pubmed.ncbi.nlm.nih.gov/6219223 DM3N9O5 DI DM3N9O5 DM3N9O5 DN 4-(5-Phenyl-oxazol-2-ylamino)-benzenesulfonamide DM3N9O5 MI TTUTJGQ DM3N9O5 MN Vascular endothelial growth factor receptor 2 (KDR) DM3N9O5 MT DTT DM3N9O5 MA Inhibitor DM3N9O5 RN Discovery and evaluation of 2-anilino-5-aryloxazoles as a novel class of VEGFR2 kinase inhibitors. J Med Chem. 2005 Mar 10;48(5):1610-9. DM3N9O5 RU https://pubmed.ncbi.nlm.nih.gov/15743202 DM3N9O5 DI DM3N9O5 DM3N9O5 DN 4-(5-Phenyl-oxazol-2-ylamino)-benzenesulfonamide DM3N9O5 MI TTDCBX5 DM3N9O5 MN Vascular endothelial growth factor receptor 3 (FLT-4) DM3N9O5 MT DTT DM3N9O5 MA Inhibitor DM3N9O5 RN Discovery and evaluation of 2-anilino-5-aryloxazoles as a novel class of VEGFR2 kinase inhibitors. J Med Chem. 2005 Mar 10;48(5):1610-9. DM3N9O5 RU https://pubmed.ncbi.nlm.nih.gov/15743202 DM3N9O5 DI DM3N9O5 DM3N9O5 DN 4-(5-Phenyl-oxazol-2-ylamino)-benzenesulfonamide DM3N9O5 MI TT1VAUK DM3N9O5 MN VEGFR1 messenger RNA (VEGFR1 mRNA) DM3N9O5 MT DTT DM3N9O5 MA Inhibitor DM3N9O5 RN Discovery and evaluation of 2-anilino-5-aryloxazoles as a novel class of VEGFR2 kinase inhibitors. J Med Chem. 2005 Mar 10;48(5):1610-9. DM3N9O5 RU https://pubmed.ncbi.nlm.nih.gov/15743202 DMZ1DW0 DI DMZ1DW0 DMZ1DW0 DN 4-(5-tert-Butyl-[1,3]dithian-2-yl)-benzonitrile DMZ1DW0 MI TTNJYV2 DMZ1DW0 MN Gamma-aminobutyric acid receptor (GAR) DMZ1DW0 MT DTT DMZ1DW0 MA Inhibitor DMZ1DW0 RN Synthesis of carbon-11-, fluorine-18-, and iodine-125-labeled GABAA-gated chloride ion channel blockers: substituted 5-tert-butyl-2-phenyl-1,3-dith... J Med Chem. 1995 Jul 7;38(14):2663-71. DMZ1DW0 RU https://pubmed.ncbi.nlm.nih.gov/7629805 DM8A6UH DI DM8A6UH DM8A6UH DN 4-(6,7-Dimethoxy-quinolin-3-yl)-benzoic acid DM8A6UH MI TT8FYO9 DM8A6UH MN Platelet-derived growth factor receptor alpha (PDGFRA) DM8A6UH MT DTT DM8A6UH MA Inhibitor DM8A6UH RN A new series of PDGF receptor tyrosine kinase inhibitors: 3-substituted quinoline derivatives. J Med Chem. 1994 Jul 8;37(14):2129-37. DM8A6UH RU https://pubmed.ncbi.nlm.nih.gov/8035419 DM8A6UH DI DM8A6UH DM8A6UH DN 4-(6,7-Dimethoxy-quinolin-3-yl)-benzoic acid DM8A6UH MI TTI7421 DM8A6UH MN Platelet-derived growth factor receptor beta (PDGFRB) DM8A6UH MT DTT DM8A6UH MA Inhibitor DM8A6UH RN A new series of PDGF receptor tyrosine kinase inhibitors: 3-substituted quinoline derivatives. J Med Chem. 1994 Jul 8;37(14):2129-37. DM8A6UH RU https://pubmed.ncbi.nlm.nih.gov/8035419 DM9RNUX DI DM9RNUX DM9RNUX DN 4-(6,7-Dimethoxy-quinolin-3-yl)-phenol DM9RNUX MI TT8FYO9 DM9RNUX MN Platelet-derived growth factor receptor alpha (PDGFRA) DM9RNUX MT DTT DM9RNUX MA Inhibitor DM9RNUX RN A new series of PDGF receptor tyrosine kinase inhibitors: 3-substituted quinoline derivatives. J Med Chem. 1994 Jul 8;37(14):2129-37. DM9RNUX RU https://pubmed.ncbi.nlm.nih.gov/8035419 DM9RNUX DI DM9RNUX DM9RNUX DN 4-(6,7-Dimethoxy-quinolin-3-yl)-phenol DM9RNUX MI TTI7421 DM9RNUX MN Platelet-derived growth factor receptor beta (PDGFRB) DM9RNUX MT DTT DM9RNUX MA Inhibitor DM9RNUX RN A new series of PDGF receptor tyrosine kinase inhibitors: 3-substituted quinoline derivatives. J Med Chem. 1994 Jul 8;37(14):2129-37. DM9RNUX RU https://pubmed.ncbi.nlm.nih.gov/8035419 DMPD9GE DI DMPD9GE DMPD9GE DN 4-(6-Cyclohexyl-hex-3-ynyl)-1H-imidazole DMPD9GE MI TT9JNIC DMPD9GE MN Histamine H3 receptor (H3R) DMPD9GE MT DTT DMPD9GE MA Inhibitor DMPD9GE RN New acetylene based histamine H3 receptor antagonists derived from the marine natural product verongamine. Bioorg Med Chem Lett. 1998 May 19;8(10):1133-8. DMPD9GE RU https://pubmed.ncbi.nlm.nih.gov/9871722 DM4EC0J DI DM4EC0J DM4EC0J DN 4-(6-Cyclopentyl-hex-3-ynyl)-1H-imidazole DM4EC0J MI TT9JNIC DM4EC0J MN Histamine H3 receptor (H3R) DM4EC0J MT DTT DM4EC0J MA Inhibitor DM4EC0J RN New acetylene based histamine H3 receptor antagonists derived from the marine natural product verongamine. Bioorg Med Chem Lett. 1998 May 19;8(10):1133-8. DM4EC0J RU https://pubmed.ncbi.nlm.nih.gov/9871722 DMHGRPB DI DMHGRPB DMHGRPB DN 4-(6-HYDROXY-1H-INDAZOL-3-YL)BENZENE-1,3-DIOL DMHGRPB MI TTZAYWL DMHGRPB MN Estrogen receptor (ESR) DMHGRPB MT DTT DMHGRPB MA Inhibitor DMHGRPB RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DMHGRPB RU https://pubmed.ncbi.nlm.nih.gov/10592235 DM38YZ4 DI DM38YZ4 DM38YZ4 DN 4-(6-Hydroxy-benzooxazol-2-yl)-benzene-1,2-diol DM38YZ4 MI TTZAYWL DM38YZ4 MN Estrogen receptor (ESR) DM38YZ4 MT DTT DM38YZ4 MA Inhibitor DM38YZ4 RN Design and synthesis of aryl diphenolic azoles as potent and selective estrogen receptor-beta ligands. J Med Chem. 2004 Oct 7;47(21):5021-40. DM38YZ4 RU https://pubmed.ncbi.nlm.nih.gov/15456246 DM38YZ4 DI DM38YZ4 DM38YZ4 DN 4-(6-Hydroxy-benzooxazol-2-yl)-benzene-1,2-diol DM38YZ4 MI TTOM3J0 DM38YZ4 MN Estrogen receptor beta (ESR2) DM38YZ4 MT DTT DM38YZ4 MA Inhibitor DM38YZ4 RN Design and synthesis of aryl diphenolic azoles as potent and selective estrogen receptor-beta ligands. J Med Chem. 2004 Oct 7;47(21):5021-40. DM38YZ4 RU https://pubmed.ncbi.nlm.nih.gov/15456246 DM07NT9 DI DM07NT9 DM07NT9 DN 4-(6-Hydroxy-benzooxazol-2-yl)-benzene-1,3-diol DM07NT9 MI TTZAYWL DM07NT9 MN Estrogen receptor (ESR) DM07NT9 MT DTT DM07NT9 MA Inhibitor DM07NT9 RN Design and synthesis of aryl diphenolic azoles as potent and selective estrogen receptor-beta ligands. J Med Chem. 2004 Oct 7;47(21):5021-40. DM07NT9 RU https://pubmed.ncbi.nlm.nih.gov/15456246 DM07NT9 DI DM07NT9 DM07NT9 DN 4-(6-Hydroxy-benzooxazol-2-yl)-benzene-1,3-diol DM07NT9 MI TTOM3J0 DM07NT9 MN Estrogen receptor beta (ESR2) DM07NT9 MT DTT DM07NT9 MA Inhibitor DM07NT9 RN Design and synthesis of aryl diphenolic azoles as potent and selective estrogen receptor-beta ligands. J Med Chem. 2004 Oct 7;47(21):5021-40. DM07NT9 RU https://pubmed.ncbi.nlm.nih.gov/15456246 DM4SPV7 DI DM4SPV7 DM4SPV7 DN 4-(6-hydroxynaphthalen-2-yl)benzene-1,3-diol DM4SPV7 MI TTULVH8 DM4SPV7 MN Tyrosinase (TYR) DM4SPV7 MT DTT DM4SPV7 MA Inhibitor DM4SPV7 RN Syntheses of hydroxy substituted 2-phenyl-naphthalenes as inhibitors of tyrosinase. Bioorg Med Chem Lett. 2007 Jan 15;17(2):461-4. DM4SPV7 RU https://pubmed.ncbi.nlm.nih.gov/17064896 DM3L5I6 DI DM3L5I6 DM3L5I6 DN 4-(6-methoxy-1H-indol-1-ylsulfonyl)benzenamine DM3L5I6 MI TTJS8PY DM3L5I6 MN 5-HT 6 receptor (HTR6) DM3L5I6 MT DTT DM3L5I6 MA Inhibitor DM3L5I6 RN Binding of methoxy-substituted N1-benzenesulfonylindole analogs at human 5-HT6 serotonin receptors. Bioorg Med Chem Lett. 2006 Jul 15;16(14):3793-6. DM3L5I6 RU https://pubmed.ncbi.nlm.nih.gov/16709453 DM3ACVD DI DM3ACVD DM3ACVD DN 4-(6-methoxy-3,4-dihydronaphthalen-2-yl)pyridine DM3ACVD MI TTIQUX7 DM3ACVD MN Steroid 11-beta-hydroxylase (CYP11B1) DM3ACVD MT DTT DM3ACVD MA Inhibitor DM3ACVD RN Synthesis and evaluation of heteroaryl-substituted dihydronaphthalenes and indenes: potent and selective inhibitors of aldosterone synthase (CYP11B... J Med Chem. 2006 Apr 6;49(7):2222-31. DM3ACVD RU https://pubmed.ncbi.nlm.nih.gov/16570918 DMRPU0V DI DMRPU0V DMRPU0V DN 4-(6-Methoxy-3-methylnaphthalen-2-yl)isoquinoline DMRPU0V MI TTIQUX7 DMRPU0V MN Steroid 11-beta-hydroxylase (CYP11B1) DMRPU0V MT DTT DMRPU0V MA Inhibitor DMRPU0V RN Overcoming undesirable CYP1A2 inhibition of pyridylnaphthalene-type aldosterone synthase inhibitors: influence of heteroaryl derivatization on pote... J Med Chem. 2008 Aug 28;51(16):5064-74. DMRPU0V RU https://pubmed.ncbi.nlm.nih.gov/18672861 DM51XDA DI DM51XDA DM51XDA DN 4-(6-Methoxynaphthalen-2-yl)isoquinoline DM51XDA MI TTXV4FI DM51XDA MN Albendazole monooxygenase (CYP3A4) DM51XDA MT DTT DM51XDA MA Inhibitor DM51XDA RN Overcoming undesirable CYP1A2 inhibition of pyridylnaphthalene-type aldosterone synthase inhibitors: influence of heteroaryl derivatization on pote... J Med Chem. 2008 Aug 28;51(16):5064-74. DM51XDA RU https://pubmed.ncbi.nlm.nih.gov/18672861 DM51XDA DI DM51XDA DM51XDA DN 4-(6-Methoxynaphthalen-2-yl)isoquinoline DM51XDA MI TTIQUX7 DM51XDA MN Steroid 11-beta-hydroxylase (CYP11B1) DM51XDA MT DTT DM51XDA MA Inhibitor DM51XDA RN Overcoming undesirable CYP1A2 inhibition of pyridylnaphthalene-type aldosterone synthase inhibitors: influence of heteroaryl derivatization on pote... J Med Chem. 2008 Aug 28;51(16):5064-74. DM51XDA RU https://pubmed.ncbi.nlm.nih.gov/18672861 DM4B73F DI DM4B73F DM4B73F DN 4'-(6-Methoxypyridin-3-yl)biphenyl-3-ol DM4B73F MI TTIWB6L DM4B73F MN Estradiol 17 beta-dehydrogenase 1 (17-beta-HSD1) DM4B73F MT DTT DM4B73F MA Inhibitor DM4B73F RN Novel estrone mimetics with high 17beta-HSD1 inhibitory activity. Bioorg Med Chem. 2010 May 15;18(10):3494-505. DM4B73F RU https://pubmed.ncbi.nlm.nih.gov/20413314 DM9O8VY DI DM9O8VY DM9O8VY DN 4-(6-morpholino-4-oxo-4H-pyran-2-yl)benzonitrile DM9O8VY MI TTK3PY9 DM9O8VY MN DNA-dependent protein kinase catalytic (PRKDC) DM9O8VY MT DTT DM9O8VY MA Inhibitor DM9O8VY RN Pyranone, thiopyranone, and pyridone inhibitors of phosphatidylinositol 3-kinase related kinases. Structure-activity relationships for DNA-dependen... J Med Chem. 2007 Apr 19;50(8):1958-72. DM9O8VY RU https://pubmed.ncbi.nlm.nih.gov/17371003 DM1Z3N6 DI DM1Z3N6 DM1Z3N6 DN 4-(6-morpholino-9H-purin-2-yl)phenol DM1Z3N6 MI TTCJG29 DM1Z3N6 MN Serine/threonine-protein kinase mTOR (mTOR) DM1Z3N6 MT DTT DM1Z3N6 MA Inhibitor DM1Z3N6 RN Novel purine and pyrazolo[3,4-d]pyrimidine inhibitors of PI3 kinase-alpha: Hit to lead studies. Bioorg Med Chem Lett. 2010 Jan 15;20(2):636-9. DM1Z3N6 RU https://pubmed.ncbi.nlm.nih.gov/19969455 DMJ81IL DI DMJ81IL DMJ81IL DN 4-(6-phenyl-2,4'-bipyridin-4-yl)phenol DMJ81IL MI TTGTQHC DMJ81IL MN DNA topoisomerase I (TOP1) DMJ81IL MT DTT DMJ81IL MA Inhibitor DMJ81IL RN Synthesis, topoisomerase I and II inhibitory activity, cytotoxicity, and structure-activity relationship study of hydroxylated 2,4-diphenyl-6-aryl ... Bioorg Med Chem. 2010 May 1;18(9):3066-77. DMJ81IL RU https://pubmed.ncbi.nlm.nih.gov/20392646 DMIY5QU DI DMIY5QU DMIY5QU DN 4-(7,7-Dimethyl-oct-3-ynyl)-1H-imidazole DMIY5QU MI TT9JNIC DMIY5QU MN Histamine H3 receptor (H3R) DMIY5QU MT DTT DMIY5QU MA Inhibitor DMIY5QU RN New acetylene based histamine H3 receptor antagonists derived from the marine natural product verongamine. Bioorg Med Chem Lett. 1998 May 19;8(10):1133-8. DMIY5QU RU https://pubmed.ncbi.nlm.nih.gov/9871722 DMUXZOM DI DMUXZOM DMUXZOM DN 4-(7-chloro-1-cyclohexyl-1H-indazol-3-yl)phenol DMUXZOM MI TTZAYWL DMUXZOM MN Estrogen receptor (ESR) DMUXZOM MT DTT DMUXZOM MA Inhibitor DMUXZOM RN Synthesis and activity of substituted 4-(indazol-3-yl)phenols as pathway-selective estrogen receptor ligands useful in the treatment of rheumatoid ... J Med Chem. 2004 Dec 16;47(26):6435-8. DMUXZOM RU https://pubmed.ncbi.nlm.nih.gov/15588074 DM0X5SY DI DM0X5SY DM0X5SY DN 4-(7-chloro-1-cyclopentyl-1H-indazol-3-yl)phenol DM0X5SY MI TTZAYWL DM0X5SY MN Estrogen receptor (ESR) DM0X5SY MT DTT DM0X5SY MA Inhibitor DM0X5SY RN Synthesis and activity of substituted 4-(indazol-3-yl)phenols as pathway-selective estrogen receptor ligands useful in the treatment of rheumatoid ... J Med Chem. 2004 Dec 16;47(26):6435-8. DM0X5SY RU https://pubmed.ncbi.nlm.nih.gov/15588074 DMEYUH0 DI DMEYUH0 DMEYUH0 DN 4-(7-chloro-1-propyl-1H-indazol-3-yl)phenol DMEYUH0 MI TTZAYWL DMEYUH0 MN Estrogen receptor (ESR) DMEYUH0 MT DTT DMEYUH0 MA Inhibitor DMEYUH0 RN Synthesis and activity of substituted 4-(indazol-3-yl)phenols as pathway-selective estrogen receptor ligands useful in the treatment of rheumatoid ... J Med Chem. 2004 Dec 16;47(26):6435-8. DMEYUH0 RU https://pubmed.ncbi.nlm.nih.gov/15588074 DMX2K8R DI DMX2K8R DMX2K8R DN 4-(7-methyl-1-propyl-1H-indazol-3-yl)phenol DMX2K8R MI TTZAYWL DMX2K8R MN Estrogen receptor (ESR) DMX2K8R MT DTT DMX2K8R MA Inhibitor DMX2K8R RN Synthesis and activity of substituted 4-(indazol-3-yl)phenols as pathway-selective estrogen receptor ligands useful in the treatment of rheumatoid ... J Med Chem. 2004 Dec 16;47(26):6435-8. DMX2K8R RU https://pubmed.ncbi.nlm.nih.gov/15588074 DMJ86OS DI DMJ86OS DMJ86OS DN 4-(7-Methyl-oct-3-ynyl)-1H-imidazole DMJ86OS MI TT9JNIC DMJ86OS MN Histamine H3 receptor (H3R) DMJ86OS MT DTT DMJ86OS MA Inhibitor DMJ86OS RN New acetylene based histamine H3 receptor antagonists derived from the marine natural product verongamine. Bioorg Med Chem Lett. 1998 May 19;8(10):1133-8. DMJ86OS RU https://pubmed.ncbi.nlm.nih.gov/9871722 DM27OGL DI DM27OGL DM27OGL DN 4-(8-Phenyl-oct-3-ynyl)-1H-imidazole DM27OGL MI TT9JNIC DM27OGL MN Histamine H3 receptor (H3R) DM27OGL MT DTT DM27OGL MA Inhibitor DM27OGL RN New acetylene based histamine H3 receptor antagonists derived from the marine natural product verongamine. Bioorg Med Chem Lett. 1998 May 19;8(10):1133-8. DM27OGL RU https://pubmed.ncbi.nlm.nih.gov/9871722 DMR37FN DI DMR37FN DMR37FN DN 4-(Acetylamino)-3-Amino Benzoic Acid DMR37FN MI TT50QJ3 DMR37FN MN Influenza Neuraminidase (Influ NA) DMR37FN MT DTT DMR37FN MA Inhibitor DMR37FN RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMR37FN RU https://pubmed.ncbi.nlm.nih.gov/17139284 DM8F0N5 DI DM8F0N5 DM8F0N5 DN 4-(ACETYLAMINO)-3-HYDROXY-5-NITROBENZOIC ACID DM8F0N5 MI TT50QJ3 DM8F0N5 MN Influenza Neuraminidase (Influ NA) DM8F0N5 MT DTT DM8F0N5 MA Inhibitor DM8F0N5 RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DM8F0N5 RU https://pubmed.ncbi.nlm.nih.gov/10592235 DM1DKSV DI DM1DKSV DM1DKSV DN 4-(ACETYLAMINO)-5-AMINO-3-HYDROXYBENZOIC ACID DM1DKSV MI TT50QJ3 DM1DKSV MN Influenza Neuraminidase (Influ NA) DM1DKSV MT DTT DM1DKSV MA Inhibitor DM1DKSV RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DM1DKSV RU https://pubmed.ncbi.nlm.nih.gov/10592235 DM6MQCI DI DM6MQCI DM6MQCI DN 4-(Allylamino)-3-pyridinesulfonamide DM6MQCI MI TTHQPL7 DM6MQCI MN Carbonic anhydrase I (CA-I) DM6MQCI MT DTT DM6MQCI MA Inhibitor DM6MQCI RN Carbonic anhydrase inhibitors: synthesis and inhibition of the human cytosolic isozymes I and II and transmembrane isozymes IX, XII (cancer-associa... Eur J Med Chem. 2010 Jun;45(6):2396-404. DM6MQCI RU https://pubmed.ncbi.nlm.nih.gov/20202722 DM6MQCI DI DM6MQCI DM6MQCI DN 4-(Allylamino)-3-pyridinesulfonamide DM6MQCI MI TTANPDJ DM6MQCI MN Carbonic anhydrase II (CA-II) DM6MQCI MT DTT DM6MQCI MA Inhibitor DM6MQCI RN Carbonic anhydrase inhibitors: synthesis and inhibition of the human cytosolic isozymes I and II and transmembrane isozymes IX, XII (cancer-associa... Eur J Med Chem. 2010 Jun;45(6):2396-404. DM6MQCI RU https://pubmed.ncbi.nlm.nih.gov/20202722 DM6MQCI DI DM6MQCI DM6MQCI DN 4-(Allylamino)-3-pyridinesulfonamide DM6MQCI MI TT2LVK8 DM6MQCI MN Carbonic anhydrase IX (CA-IX) DM6MQCI MT DTT DM6MQCI MA Inhibitor DM6MQCI RN Carbonic anhydrase inhibitors: synthesis and inhibition of the human cytosolic isozymes I and II and transmembrane isozymes IX, XII (cancer-associa... Eur J Med Chem. 2010 Jun;45(6):2396-404. DM6MQCI RU https://pubmed.ncbi.nlm.nih.gov/20202722 DM6MQCI DI DM6MQCI DM6MQCI DN 4-(Allylamino)-3-pyridinesulfonamide DM6MQCI MI TTSYM0R DM6MQCI MN Carbonic anhydrase XII (CA-XII) DM6MQCI MT DTT DM6MQCI MA Inhibitor DM6MQCI RN Carbonic anhydrase inhibitors: synthesis and inhibition of the human cytosolic isozymes I and II and transmembrane isozymes IX, XII (cancer-associa... Eur J Med Chem. 2010 Jun;45(6):2396-404. DM6MQCI RU https://pubmed.ncbi.nlm.nih.gov/20202722 DM6MQCI DI DM6MQCI DM6MQCI DN 4-(Allylamino)-3-pyridinesulfonamide DM6MQCI MI TTEYTKG DM6MQCI MN Carbonic anhydrase XIV (CA-XIV) DM6MQCI MT DTT DM6MQCI MA Inhibitor DM6MQCI RN Carbonic anhydrase inhibitors: synthesis and inhibition of the human cytosolic isozymes I and II and transmembrane isozymes IX, XII (cancer-associa... Eur J Med Chem. 2010 Jun;45(6):2396-404. DM6MQCI RU https://pubmed.ncbi.nlm.nih.gov/20202722 DMTB80W DI DMTB80W DMTB80W DN 4-(Aminomethyl)-7-(benzyloxy)-2H-chromen-2-one DMTB80W MI TT3WG5C DMTB80W MN Monoamine oxidase type A (MAO-A) DMTB80W MT DTT DMTB80W MA Inhibitor DMTB80W RN Discovery of a novel class of potent coumarin monoamine oxidase B inhibitors: development and biopharmacological profiling of 7-[(3-chlorobenzyl)ox... J Med Chem. 2009 Nov 12;52(21):6685-706. DMTB80W RU https://pubmed.ncbi.nlm.nih.gov/19810674 DMTB80W DI DMTB80W DMTB80W DN 4-(Aminomethyl)-7-(benzyloxy)-2H-chromen-2-one DMTB80W MI TTGP7BY DMTB80W MN Monoamine oxidase type B (MAO-B) DMTB80W MT DTT DMTB80W MA Inhibitor DMTB80W RN Discovery of a novel class of potent coumarin monoamine oxidase B inhibitors: development and biopharmacological profiling of 7-[(3-chlorobenzyl)ox... J Med Chem. 2009 Nov 12;52(21):6685-706. DMTB80W RU https://pubmed.ncbi.nlm.nih.gov/19810674 DML2EF4 DI DML2EF4 DML2EF4 DN 4'-(Benzensulfonamide)-4-hydroxychalcone DML2EF4 MI TTULVH8 DML2EF4 MN Tyrosinase (TYR) DML2EF4 MT DTT DML2EF4 MA Inhibitor DML2EF4 RN Evaluation of anti-pigmentary effect of synthetic sulfonylamino chalcone. Eur J Med Chem. 2010 May;45(5):2010-7. DML2EF4 RU https://pubmed.ncbi.nlm.nih.gov/20149498 DMF6S3X DI DMF6S3X DMF6S3X DN 4-(Benzylamino)-1-naphthol DMF6S3X MI TTZJYKH DMF6S3X MN Indoleamine 2,3-dioxygenase 1 (IDO1) DMF6S3X MT DTT DMF6S3X MA Inhibitor DMF6S3X RN Rational design of indoleamine 2,3-dioxygenase inhibitors. J Med Chem. 2010 Feb 11;53(3):1172-89. DMF6S3X RU https://pubmed.ncbi.nlm.nih.gov/20055453 DM03BQD DI DM03BQD DM03BQD DN 4-(benzylideneamino)benzenesulfonamide DM03BQD MI TTANPDJ DM03BQD MN Carbonic anhydrase II (CA-II) DM03BQD MT DTT DM03BQD MA Inhibitor DM03BQD RN Carbonic anhydrase II-induced selection of inhibitors from a dynamic combinatorial library of Schiff's bases. Bioorg Med Chem Lett. 2009 Nov 1;19(21):6014-7. DM03BQD RU https://pubmed.ncbi.nlm.nih.gov/19796939 DM03BQD DI DM03BQD DM03BQD DN 4-(benzylideneamino)benzenesulfonamide DM03BQD MI TTVKILB DM03BQD MN Prostaglandin G/H synthase 2 (COX-2) DM03BQD MT DTT DM03BQD MA Inhibitor DM03BQD RN Selective COX-2 inhibitors. Part 2: synthesis and biological evaluation of 4-benzylideneamino- and 4-phenyliminomethyl-benzenesulfonamides. Bioorg Med Chem. 2008 Mar 1;16(5):2697-706. DM03BQD RU https://pubmed.ncbi.nlm.nih.gov/18063374 DMJM2H1 DI DMJM2H1 DMJM2H1 DN 4-(benzylideneamino)benzoic acid DMJM2H1 MI TTANPDJ DMJM2H1 MN Carbonic anhydrase II (CA-II) DMJM2H1 MT DTT DMJM2H1 MA Inhibitor DMJM2H1 RN Carbonic anhydrase II-induced selection of inhibitors from a dynamic combinatorial library of Schiff's bases. Bioorg Med Chem Lett. 2009 Nov 1;19(21):6014-7. DMJM2H1 RU https://pubmed.ncbi.nlm.nih.gov/19796939 DM1T95Y DI DM1T95Y DM1T95Y DN 4-(biphenyl-3-yl)-5-(piperidin-4-yl)isoxazol-3-ol DM1T95Y MI TT1MPAY DM1T95Y MN GABA(A) receptor alpha-1 (GABRA1) DM1T95Y MT DTT DM1T95Y MA Inhibitor DM1T95Y RN Novel 4-(piperidin-4-yl)-1-hydroxypyrazoles as gamma-aminobutyric acid(A) receptor ligands: synthesis, pharmacology, and structure-activity relatio... J Med Chem. 2010 Apr 22;53(8):3417-21. DM1T95Y RU https://pubmed.ncbi.nlm.nih.gov/20355712 DM1T95Y DI DM1T95Y DM1T95Y DN 4-(biphenyl-3-yl)-5-(piperidin-4-yl)isoxazol-3-ol DM1T95Y MI TTZA1NY DM1T95Y MN GABA(A) receptor beta-2 (GABRB2) DM1T95Y MT DTT DM1T95Y MA Inhibitor DM1T95Y RN Novel 4-(piperidin-4-yl)-1-hydroxypyrazoles as gamma-aminobutyric acid(A) receptor ligands: synthesis, pharmacology, and structure-activity relatio... J Med Chem. 2010 Apr 22;53(8):3417-21. DM1T95Y RU https://pubmed.ncbi.nlm.nih.gov/20355712 DM1T95Y DI DM1T95Y DM1T95Y DN 4-(biphenyl-3-yl)-5-(piperidin-4-yl)isoxazol-3-ol DM1T95Y MI TT06RH5 DM1T95Y MN GABA(A) receptor gamma-2 (GABRG2) DM1T95Y MT DTT DM1T95Y MA Inhibitor DM1T95Y RN Novel 4-(piperidin-4-yl)-1-hydroxypyrazoles as gamma-aminobutyric acid(A) receptor ligands: synthesis, pharmacology, and structure-activity relatio... J Med Chem. 2010 Apr 22;53(8):3417-21. DM1T95Y RU https://pubmed.ncbi.nlm.nih.gov/20355712 DMNE5H7 DI DMNE5H7 DMNE5H7 DN 4-(Bis(2-chloroethyl)amino)-N-p-tolylbenzamide DMNE5H7 MI TTR5TV4 DMNE5H7 MN ERBB2 messenger RNA (HER2 mRNA) DMNE5H7 MT DTT DMNE5H7 MA Inhibitor DMNE5H7 RN Synthesis, biological evaluation and molecular docking studies of amide-coupled benzoic nitrogen mustard derivatives as potential antitumor agents. Bioorg Med Chem. 2010 Jan 15;18(2):880-6. DMNE5H7 RU https://pubmed.ncbi.nlm.nih.gov/20005116 DM3GUFI DI DM3GUFI DM3GUFI DN 4-(butyl(methyl)amino)-N-(quinolin-3-yl)benzamide DM3GUFI MI TTMI6F5 DM3GUFI MN Transient receptor potential cation channel V1 (TRPV1) DM3GUFI MT DTT DM3GUFI MA Inhibitor DM3GUFI RN N-pyridin-3-yl- and N-quinolin-3-yl-benzamides: modulators of human vanilloid receptor 1 (TRPV1). Bioorg Med Chem Lett. 2008 Apr 15;18(8):2730-4. DM3GUFI RU https://pubmed.ncbi.nlm.nih.gov/18359227 DM6SIA4 DI DM6SIA4 DM6SIA4 DN 4-(butylthio)-2-(trifluoromethyl)benzonitrile DM6SIA4 MI TTKPW01 DM6SIA4 MN Androgen receptor messenger RNA (AR mRNA) DM6SIA4 MT DTT DM6SIA4 MA Inhibitor DM6SIA4 RN 4-(Alkylthio)- and 4-(arylthio)-benzonitrile derivatives as androgen receptor antagonists for the topical suppression of sebum production. Bioorg Med Chem Lett. 2009 Mar 1;19(5):1310-3. DM6SIA4 RU https://pubmed.ncbi.nlm.nih.gov/19201190 DMH1AZV DI DMH1AZV DMH1AZV DN 4-(butylthio)-2-methoxybenzonitrile DMH1AZV MI TTKPW01 DMH1AZV MN Androgen receptor messenger RNA (AR mRNA) DMH1AZV MT DTT DMH1AZV MA Inhibitor DMH1AZV RN 4-(Alkylthio)- and 4-(arylthio)-benzonitrile derivatives as androgen receptor antagonists for the topical suppression of sebum production. Bioorg Med Chem Lett. 2009 Mar 1;19(5):1310-3. DMH1AZV RU https://pubmed.ncbi.nlm.nih.gov/19201190 DM12R4M DI DM12R4M DM12R4M DN 4-(Carbamolymethylthio)pyridine-3-sulfonamide DM12R4M MI TTHQPL7 DM12R4M MN Carbonic anhydrase I (CA-I) DM12R4M MT DTT DM12R4M MA Inhibitor DM12R4M RN Carbonic anhydrase inhibitors: synthesis and inhibition of the human cytosolic isozymes I and II and transmembrane isozymes IX, XII (cancer-associa... Eur J Med Chem. 2010 Jun;45(6):2396-404. DM12R4M RU https://pubmed.ncbi.nlm.nih.gov/20202722 DM12R4M DI DM12R4M DM12R4M DN 4-(Carbamolymethylthio)pyridine-3-sulfonamide DM12R4M MI TTANPDJ DM12R4M MN Carbonic anhydrase II (CA-II) DM12R4M MT DTT DM12R4M MA Inhibitor DM12R4M RN Carbonic anhydrase inhibitors: synthesis and inhibition of the human cytosolic isozymes I and II and transmembrane isozymes IX, XII (cancer-associa... Eur J Med Chem. 2010 Jun;45(6):2396-404. DM12R4M RU https://pubmed.ncbi.nlm.nih.gov/20202722 DM12R4M DI DM12R4M DM12R4M DN 4-(Carbamolymethylthio)pyridine-3-sulfonamide DM12R4M MI TT2LVK8 DM12R4M MN Carbonic anhydrase IX (CA-IX) DM12R4M MT DTT DM12R4M MA Inhibitor DM12R4M RN Carbonic anhydrase inhibitors: synthesis and inhibition of the human cytosolic isozymes I and II and transmembrane isozymes IX, XII (cancer-associa... Eur J Med Chem. 2010 Jun;45(6):2396-404. DM12R4M RU https://pubmed.ncbi.nlm.nih.gov/20202722 DM12R4M DI DM12R4M DM12R4M DN 4-(Carbamolymethylthio)pyridine-3-sulfonamide DM12R4M MI TTSYM0R DM12R4M MN Carbonic anhydrase XII (CA-XII) DM12R4M MT DTT DM12R4M MA Inhibitor DM12R4M RN Carbonic anhydrase inhibitors: synthesis and inhibition of the human cytosolic isozymes I and II and transmembrane isozymes IX, XII (cancer-associa... Eur J Med Chem. 2010 Jun;45(6):2396-404. DM12R4M RU https://pubmed.ncbi.nlm.nih.gov/20202722 DM12R4M DI DM12R4M DM12R4M DN 4-(Carbamolymethylthio)pyridine-3-sulfonamide DM12R4M MI TTEYTKG DM12R4M MN Carbonic anhydrase XIV (CA-XIV) DM12R4M MT DTT DM12R4M MA Inhibitor DM12R4M RN Carbonic anhydrase inhibitors: synthesis and inhibition of the human cytosolic isozymes I and II and transmembrane isozymes IX, XII (cancer-associa... Eur J Med Chem. 2010 Jun;45(6):2396-404. DM12R4M RU https://pubmed.ncbi.nlm.nih.gov/20202722 DMSG9LV DI DMSG9LV DMSG9LV DN 4-(Carboxyvin-2-Yl)Phenylboronic Acid DMSG9LV MI TTHI19T DMSG9LV MN Staphylococcus Beta-lactamase (Stap-coc blaZ) DMSG9LV MT DTT DMSG9LV MA Inhibitor DMSG9LV RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMSG9LV RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMZP20H DI DMZP20H DMZP20H DN 4-(Cyanomethylthio)pyridine-3-sulfonamide DMZP20H MI TTHQPL7 DMZP20H MN Carbonic anhydrase I (CA-I) DMZP20H MT DTT DMZP20H MA Inhibitor DMZP20H RN Carbonic anhydrase inhibitors: synthesis and inhibition of the human cytosolic isozymes I and II and transmembrane isozymes IX, XII (cancer-associa... Eur J Med Chem. 2010 Jun;45(6):2396-404. DMZP20H RU https://pubmed.ncbi.nlm.nih.gov/20202722 DMZP20H DI DMZP20H DMZP20H DN 4-(Cyanomethylthio)pyridine-3-sulfonamide DMZP20H MI TTANPDJ DMZP20H MN Carbonic anhydrase II (CA-II) DMZP20H MT DTT DMZP20H MA Inhibitor DMZP20H RN Carbonic anhydrase inhibitors: synthesis and inhibition of the human cytosolic isozymes I and II and transmembrane isozymes IX, XII (cancer-associa... Eur J Med Chem. 2010 Jun;45(6):2396-404. DMZP20H RU https://pubmed.ncbi.nlm.nih.gov/20202722 DMZP20H DI DMZP20H DMZP20H DN 4-(Cyanomethylthio)pyridine-3-sulfonamide DMZP20H MI TT2LVK8 DMZP20H MN Carbonic anhydrase IX (CA-IX) DMZP20H MT DTT DMZP20H MA Inhibitor DMZP20H RN Carbonic anhydrase inhibitors: synthesis and inhibition of the human cytosolic isozymes I and II and transmembrane isozymes IX, XII (cancer-associa... Eur J Med Chem. 2010 Jun;45(6):2396-404. DMZP20H RU https://pubmed.ncbi.nlm.nih.gov/20202722 DMZP20H DI DMZP20H DMZP20H DN 4-(Cyanomethylthio)pyridine-3-sulfonamide DMZP20H MI TTSYM0R DMZP20H MN Carbonic anhydrase XII (CA-XII) DMZP20H MT DTT DMZP20H MA Inhibitor DMZP20H RN Carbonic anhydrase inhibitors: synthesis and inhibition of the human cytosolic isozymes I and II and transmembrane isozymes IX, XII (cancer-associa... Eur J Med Chem. 2010 Jun;45(6):2396-404. DMZP20H RU https://pubmed.ncbi.nlm.nih.gov/20202722 DMZP20H DI DMZP20H DMZP20H DN 4-(Cyanomethylthio)pyridine-3-sulfonamide DMZP20H MI TTEYTKG DMZP20H MN Carbonic anhydrase XIV (CA-XIV) DMZP20H MT DTT DMZP20H MA Inhibitor DMZP20H RN Carbonic anhydrase inhibitors: synthesis and inhibition of the human cytosolic isozymes I and II and transmembrane isozymes IX, XII (cancer-associa... Eur J Med Chem. 2010 Jun;45(6):2396-404. DMZP20H RU https://pubmed.ncbi.nlm.nih.gov/20202722 DMR69K2 DI DMR69K2 DMR69K2 DN 4-(cyclobutylmethylthio)-2-methoxybenzonitrile DMR69K2 MI TTKPW01 DMR69K2 MN Androgen receptor messenger RNA (AR mRNA) DMR69K2 MT DTT DMR69K2 MA Inhibitor DMR69K2 RN 4-(Alkylthio)- and 4-(arylthio)-benzonitrile derivatives as androgen receptor antagonists for the topical suppression of sebum production. Bioorg Med Chem Lett. 2009 Mar 1;19(5):1310-3. DMR69K2 RU https://pubmed.ncbi.nlm.nih.gov/19201190 DMUOQN7 DI DMUOQN7 DMUOQN7 DN 4-(Cyclohexylamino)-1-naphthol DMUOQN7 MI TTZJYKH DMUOQN7 MN Indoleamine 2,3-dioxygenase 1 (IDO1) DMUOQN7 MT DTT DMUOQN7 MA Inhibitor DMUOQN7 RN Rational design of indoleamine 2,3-dioxygenase inhibitors. J Med Chem. 2010 Feb 11;53(3):1172-89. DMUOQN7 RU https://pubmed.ncbi.nlm.nih.gov/20055453 DMWELVK DI DMWELVK DMWELVK DN 4-(cyclohexylamino)-N-(quinolin-3-yl)benzamide DMWELVK MI TTMI6F5 DMWELVK MN Transient receptor potential cation channel V1 (TRPV1) DMWELVK MT DTT DMWELVK MA Inhibitor DMWELVK RN N-pyridin-3-yl- and N-quinolin-3-yl-benzamides: modulators of human vanilloid receptor 1 (TRPV1). Bioorg Med Chem Lett. 2008 Apr 15;18(8):2730-4. DMWELVK RU https://pubmed.ncbi.nlm.nih.gov/18359227 DMWYESB DI DMWYESB DMWYESB DN 4-(cyclohexylmethylcarbamoyloxy)benzoic acid DMWYESB MI TTDP1UC DMWYESB MN Fatty acid amide hydrolase (FAAH) DMWYESB MT DTT DMWYESB MA Inhibitor DMWYESB RN Discovery and development of fatty acid amide hydrolase (FAAH) inhibitors. J Med Chem. 2008 Dec 11;51(23):7327-43. DMWYESB RU https://pubmed.ncbi.nlm.nih.gov/18983142 DMCDZ7E DI DMCDZ7E DMCDZ7E DN 4-(cyclohexyloxy)quinazoline DMCDZ7E MI TTVBPDM DMCDZ7E MN Metabotropic glutamate receptor 1 (mGluR1) DMCDZ7E MT DTT DMCDZ7E MA Inhibitor DMCDZ7E RN In vitro and in vivo SAR of pyrido[3,4-d]pyramid-4-ylamine based mGluR1 antagonists. Bioorg Med Chem Lett. 2009 Apr 15;19(8):2190-4. DMCDZ7E RU https://pubmed.ncbi.nlm.nih.gov/19289283 DM43Z2J DI DM43Z2J DM43Z2J DN 4-(cyclopropylmethylthio)-2-methoxybenzonitrile DM43Z2J MI TTKPW01 DM43Z2J MN Androgen receptor messenger RNA (AR mRNA) DM43Z2J MT DTT DM43Z2J MA Inhibitor DM43Z2J RN 4-(Alkylthio)- and 4-(arylthio)-benzonitrile derivatives as androgen receptor antagonists for the topical suppression of sebum production. Bioorg Med Chem Lett. 2009 Mar 1;19(5):1310-3. DM43Z2J RU https://pubmed.ncbi.nlm.nih.gov/19201190 DM68S9F DI DM68S9F DM68S9F DN 4-(DIMETHYLAMINO)BUTYL IMIDOTHIOCARBAMATE DM68S9F MI TT2B6EV DM68S9F MN Histamine N-methyltransferase (HNMT) DM68S9F MT DTT DM68S9F MA Inhibitor DM68S9F RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DM68S9F RU https://pubmed.ncbi.nlm.nih.gov/10592235 DMJP5YH DI DMJP5YH DMJP5YH DN 4-(dimethylamino)-N-(thiazol-2-yl)benzamide DMJP5YH MI TTSJ6Q4 DMJP5YH MN LOX-5 messenger RNA (ALOX5 mRNA) DMJP5YH MT DTT DMJP5YH MA Inhibitor DMJP5YH RN Identification of natural-product-derived inhibitors of 5-lipoxygenase activity by ligand-based virtual screening. J Med Chem. 2007 May 31;50(11):2640-6. DMJP5YH RU https://pubmed.ncbi.nlm.nih.gov/17461565 DM14C9V DI DM14C9V DM14C9V DN 4-(ethylamino)naphthalen-1-ol DM14C9V MI TTZJYKH DM14C9V MN Indoleamine 2,3-dioxygenase 1 (IDO1) DM14C9V MT DTT DM14C9V MA Inhibitor DM14C9V RN Rational design of indoleamine 2,3-dioxygenase inhibitors. J Med Chem. 2010 Feb 11;53(3):1172-89. DM14C9V RU https://pubmed.ncbi.nlm.nih.gov/20055453 DM0GCEK DI DM0GCEK DM0GCEK DN 4-(ethylthio)-6-phenyl-1,3,5-triazin-2-amine DM0GCEK MI TTK25J1 DM0GCEK MN Adenosine A1 receptor (ADORA1) DM0GCEK MT DTT DM0GCEK MA Inhibitor DM0GCEK RN Identification of non-furan containing A2A antagonists using database mining and molecular similarity approaches. Bioorg Med Chem Lett. 2006 Dec 1;16(23):5993-7. DM0GCEK RU https://pubmed.ncbi.nlm.nih.gov/16971117 DM0GCEK DI DM0GCEK DM0GCEK DN 4-(ethylthio)-6-phenyl-1,3,5-triazin-2-amine DM0GCEK MI TTM2AOE DM0GCEK MN Adenosine A2a receptor (ADORA2A) DM0GCEK MT DTT DM0GCEK MA Inhibitor DM0GCEK RN Identification of non-furan containing A2A antagonists using database mining and molecular similarity approaches. Bioorg Med Chem Lett. 2006 Dec 1;16(23):5993-7. DM0GCEK RU https://pubmed.ncbi.nlm.nih.gov/16971117 DMY7035 DI DMY7035 DMY7035 DN 4-(furan-2-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine DMY7035 MI TTK25J1 DMY7035 MN Adenosine A1 receptor (ADORA1) DMY7035 MT DTT DMY7035 MA Inhibitor DMY7035 RN Antagonists of the human A(2A) adenosine receptor. 4. Design, synthesis, and preclinical evaluation of 7-aryltriazolo[4,5-d]pyrimidines. J Med Chem. 2009 Jan 8;52(1):33-47. DMY7035 RU https://pubmed.ncbi.nlm.nih.gov/19072055 DMY7035 DI DMY7035 DMY7035 DN 4-(furan-2-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine DMY7035 MI TTM2AOE DMY7035 MN Adenosine A2a receptor (ADORA2A) DMY7035 MT DTT DMY7035 MA Inhibitor DMY7035 RN Antagonists of the human A(2A) adenosine receptor. 4. Design, synthesis, and preclinical evaluation of 7-aryltriazolo[4,5-d]pyrimidines. J Med Chem. 2009 Jan 8;52(1):33-47. DMY7035 RU https://pubmed.ncbi.nlm.nih.gov/19072055 DM7LVKP DI DM7LVKP DM7LVKP DN 4-(furan-2-yl)thieno[3,2-d]pyrimidin-2-amine DM7LVKP MI TTK25J1 DM7LVKP MN Adenosine A1 receptor (ADORA1) DM7LVKP MT DTT DM7LVKP MA Inhibitor DM7LVKP RN Antagonists of the human adenosine A2A receptor. Part 3: Design and synthesis of pyrazolo[3,4-d]pyrimidines, pyrrolo[2,3-d]pyrimidines and 6-arylpu... Bioorg Med Chem Lett. 2008 May 1;18(9):2924-9. DM7LVKP RU https://pubmed.ncbi.nlm.nih.gov/18411049 DM7LVKP DI DM7LVKP DM7LVKP DN 4-(furan-2-yl)thieno[3,2-d]pyrimidin-2-amine DM7LVKP MI TTM2AOE DM7LVKP MN Adenosine A2a receptor (ADORA2A) DM7LVKP MT DTT DM7LVKP MA Inhibitor DM7LVKP RN Antagonists of the human adenosine A2A receptor. Part 3: Design and synthesis of pyrazolo[3,4-d]pyrimidines, pyrrolo[2,3-d]pyrimidines and 6-arylpu... Bioorg Med Chem Lett. 2008 May 1;18(9):2924-9. DM7LVKP RU https://pubmed.ncbi.nlm.nih.gov/18411049 DMW4O31 DI DMW4O31 DMW4O31 DN 4-(furan-3-yl)-2,6-di(thiophen-2-yl)pyridine DMW4O31 MI TT0IHXV DMW4O31 MN DNA topoisomerase II (TOP2) DMW4O31 MT DTT DMW4O31 MA Inhibitor DMW4O31 RN 2,6-Dithienyl-4-furyl pyridines: Synthesis, topoisomerase I and II inhibition, cytotoxicity, structure-activity relationship, and docking study. Bioorg Med Chem Lett. 2010 Jan 1;20(1):42-7. DMW4O31 RU https://pubmed.ncbi.nlm.nih.gov/19954977 DM70MRZ DI DM70MRZ DM70MRZ DN 4-(hexyl(methyl)amino)-N-(quinolin-3-yl)benzamide DM70MRZ MI TTMI6F5 DM70MRZ MN Transient receptor potential cation channel V1 (TRPV1) DM70MRZ MT DTT DM70MRZ MA Inhibitor DM70MRZ RN N-pyridin-3-yl- and N-quinolin-3-yl-benzamides: modulators of human vanilloid receptor 1 (TRPV1). Bioorg Med Chem Lett. 2008 Apr 15;18(8):2730-4. DM70MRZ RU https://pubmed.ncbi.nlm.nih.gov/18359227 DMWJN73 DI DMWJN73 DMWJN73 DN 4-(Hydroxymercury)Benzoic Acid DMWJN73 MI TTANPDJ DMWJN73 MN Carbonic anhydrase II (CA-II) DMWJN73 MT DTT DMWJN73 MA Inhibitor DMWJN73 RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMWJN73 RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMR6VWL DI DMR6VWL DMR6VWL DN 4-(hydroxymethyl)benzenesulfonamide DMR6VWL MI TTUNARX DMR6VWL MN Carbonic anhydrase (CA) DMR6VWL MT DTT DMR6VWL MA Inhibitor DMR6VWL RN Cloning, expression, post-translational modifications and inhibition studies on the latest mammalian carbonic anhydrase isoform, CA XV. J Med Chem. 2009 Feb 12;52(3):646-54. DMR6VWL RU https://pubmed.ncbi.nlm.nih.gov/19193158 DMR6VWL DI DMR6VWL DMR6VWL DN 4-(hydroxymethyl)benzenesulfonamide DMR6VWL MI TTHQPL7 DMR6VWL MN Carbonic anhydrase I (CA-I) DMR6VWL MT DTT DMR6VWL MA Inhibitor DMR6VWL RN Carbonic anhydrase inhibitors. Inhibition studies of a coral secretory isoform by sulfonamides. Bioorg Med Chem. 2009 Jul 15;17(14):5054-8. DMR6VWL RU https://pubmed.ncbi.nlm.nih.gov/19520577 DMR6VWL DI DMR6VWL DMR6VWL DN 4-(hydroxymethyl)benzenesulfonamide DMR6VWL MI TTANPDJ DMR6VWL MN Carbonic anhydrase II (CA-II) DMR6VWL MT DTT DMR6VWL MA Inhibitor DMR6VWL RN Carbonic anhydrase inhibitors. Characterization and inhibition studies of the most active beta-carbonic anhydrase from Mycobacterium tuberculosis, ... Bioorg Med Chem Lett. 2009 Dec 1;19(23):6649-54. DMR6VWL RU https://pubmed.ncbi.nlm.nih.gov/19846301 DMR6VWL DI DMR6VWL DMR6VWL DN 4-(hydroxymethyl)benzenesulfonamide DMR6VWL MI TT2LVK8 DMR6VWL MN Carbonic anhydrase IX (CA-IX) DMR6VWL MT DTT DMR6VWL MA Inhibitor DMR6VWL RN Cloning, expression, post-translational modifications and inhibition studies on the latest mammalian carbonic anhydrase isoform, CA XV. J Med Chem. 2009 Feb 12;52(3):646-54. DMR6VWL RU https://pubmed.ncbi.nlm.nih.gov/19193158 DMR6VWL DI DMR6VWL DMR6VWL DN 4-(hydroxymethyl)benzenesulfonamide DMR6VWL MI TTCFSPE DMR6VWL MN Carbonic anhydrase VI (CA-VI) DMR6VWL MT DTT DMR6VWL MA Inhibitor DMR6VWL RN Cloning, expression, post-translational modifications and inhibition studies on the latest mammalian carbonic anhydrase isoform, CA XV. J Med Chem. 2009 Feb 12;52(3):646-54. DMR6VWL RU https://pubmed.ncbi.nlm.nih.gov/19193158 DMR6VWL DI DMR6VWL DMR6VWL DN 4-(hydroxymethyl)benzenesulfonamide DMR6VWL MI TTSYM0R DMR6VWL MN Carbonic anhydrase XII (CA-XII) DMR6VWL MT DTT DMR6VWL MA Inhibitor DMR6VWL RN Carbonic anhydrase inhibitors. Inhibition of the transmembrane isozyme XII with sulfonamides-a new target for the design of antitumor and antiglauc... Bioorg Med Chem Lett. 2005 Feb 15;15(4):963-9. DMR6VWL RU https://pubmed.ncbi.nlm.nih.gov/15686894 DMR6VWL DI DMR6VWL DMR6VWL DN 4-(hydroxymethyl)benzenesulfonamide DMR6VWL MI TTEYTKG DMR6VWL MN Carbonic anhydrase XIV (CA-XIV) DMR6VWL MT DTT DMR6VWL MA Inhibitor DMR6VWL RN Carbonic anhydrase inhibitors: inhibition of the transmembrane isozyme XIV with sulfonamides. Bioorg Med Chem Lett. 2005 Sep 1;15(17):3828-33. DMR6VWL RU https://pubmed.ncbi.nlm.nih.gov/16039848 DMHI50W DI DMHI50W DMHI50W DN 4-(Indan-1-ylsulfanyl)-phenylamine DMHI50W MI TTJS8PY DMHI50W MN 5-HT 6 receptor (HTR6) DMHI50W MT DTT DMHI50W MA Inhibitor DMHI50W RN Binding of isotryptamines and indenes at h5-HT6 serotonin receptors. Bioorg Med Chem Lett. 2005 Apr 15;15(8):1987-91. DMHI50W RU https://pubmed.ncbi.nlm.nih.gov/15808453 DM201UM DI DM201UM DM201UM DN 4-(Indane-1-sulfonyl)-phenylamine DM201UM MI TTJS8PY DM201UM MN 5-HT 6 receptor (HTR6) DM201UM MT DTT DM201UM MA Inhibitor DM201UM RN Binding of isotryptamines and indenes at h5-HT6 serotonin receptors. Bioorg Med Chem Lett. 2005 Apr 15;15(8):1987-91. DM201UM RU https://pubmed.ncbi.nlm.nih.gov/15808453 DMGSZB2 DI DMGSZB2 DMGSZB2 DN 4-(isopentylthio)-2-(trifluoromethyl)benzonitrile DMGSZB2 MI TTKPW01 DMGSZB2 MN Androgen receptor messenger RNA (AR mRNA) DMGSZB2 MT DTT DMGSZB2 MA Inhibitor DMGSZB2 RN 4-(Alkylthio)- and 4-(arylthio)-benzonitrile derivatives as androgen receptor antagonists for the topical suppression of sebum production. Bioorg Med Chem Lett. 2009 Mar 1;19(5):1310-3. DMGSZB2 RU https://pubmed.ncbi.nlm.nih.gov/19201190 DML1G9S DI DML1G9S DML1G9S DN 4-(isopentylthio)-2-methoxybenzonitrile DML1G9S MI TTKPW01 DML1G9S MN Androgen receptor messenger RNA (AR mRNA) DML1G9S MT DTT DML1G9S MA Inhibitor DML1G9S RN 4-(Alkylthio)- and 4-(arylthio)-benzonitrile derivatives as androgen receptor antagonists for the topical suppression of sebum production. Bioorg Med Chem Lett. 2009 Mar 1;19(5):1310-3. DML1G9S RU https://pubmed.ncbi.nlm.nih.gov/19201190 DMJFSTX DI DMJFSTX DMJFSTX DN 4-(Isopropylamino)-1-naphthol DMJFSTX MI TTZJYKH DMJFSTX MN Indoleamine 2,3-dioxygenase 1 (IDO1) DMJFSTX MT DTT DMJFSTX MA Inhibitor DMJFSTX RN Rational design of indoleamine 2,3-dioxygenase inhibitors. J Med Chem. 2010 Feb 11;53(3):1172-89. DMJFSTX RU https://pubmed.ncbi.nlm.nih.gov/20055453 DMVDHX1 DI DMVDHX1 DMVDHX1 DN 4-(isopropylthio)-2-(trifluoromethyl)benzonitrile DMVDHX1 MI TTKPW01 DMVDHX1 MN Androgen receptor messenger RNA (AR mRNA) DMVDHX1 MT DTT DMVDHX1 MA Inhibitor DMVDHX1 RN 4-(Alkylthio)- and 4-(arylthio)-benzonitrile derivatives as androgen receptor antagonists for the topical suppression of sebum production. Bioorg Med Chem Lett. 2009 Mar 1;19(5):1310-3. DMVDHX1 RU https://pubmed.ncbi.nlm.nih.gov/19201190 DMR5HNI DI DMR5HNI DMR5HNI DN 4-(isopropylthio)-2-methoxybenzonitrile DMR5HNI MI TTKPW01 DMR5HNI MN Androgen receptor messenger RNA (AR mRNA) DMR5HNI MT DTT DMR5HNI MA Inhibitor DMR5HNI RN 4-(Alkylthio)- and 4-(arylthio)-benzonitrile derivatives as androgen receptor antagonists for the topical suppression of sebum production. Bioorg Med Chem Lett. 2009 Mar 1;19(5):1310-3. DMR5HNI RU https://pubmed.ncbi.nlm.nih.gov/19201190 DM8LODU DI DM8LODU DM8LODU DN 4-(isoquinolin-5-yl)-N-m-tolylphthalazin-1-amine DM8LODU MI TTUTJGQ DM8LODU MN Vascular endothelial growth factor receptor 2 (KDR) DM8LODU MT DTT DM8LODU MA Inhibitor DM8LODU RN Arylphthalazines. Part 2: 1-(Isoquinolin-5-yl)-4-arylamino phthalazines as potent inhibitors of VEGF receptors I and II. Bioorg Med Chem Lett. 2006 Mar 15;16(6):1579-81. DM8LODU RU https://pubmed.ncbi.nlm.nih.gov/16386418 DM8LODU DI DM8LODU DM8LODU DN 4-(isoquinolin-5-yl)-N-m-tolylphthalazin-1-amine DM8LODU MI TT1VAUK DM8LODU MN VEGFR1 messenger RNA (VEGFR1 mRNA) DM8LODU MT DTT DM8LODU MA Inhibitor DM8LODU RN Arylphthalazines. Part 2: 1-(Isoquinolin-5-yl)-4-arylamino phthalazines as potent inhibitors of VEGF receptors I and II. Bioorg Med Chem Lett. 2006 Mar 15;16(6):1579-81. DM8LODU RU https://pubmed.ncbi.nlm.nih.gov/16386418 DMS30HQ DI DMS30HQ DMS30HQ DN 4-(isoquinolin-5-yl)-N-o-tolylphthalazin-1-amine DMS30HQ MI TTUTJGQ DMS30HQ MN Vascular endothelial growth factor receptor 2 (KDR) DMS30HQ MT DTT DMS30HQ MA Inhibitor DMS30HQ RN Arylphthalazines. Part 2: 1-(Isoquinolin-5-yl)-4-arylamino phthalazines as potent inhibitors of VEGF receptors I and II. Bioorg Med Chem Lett. 2006 Mar 15;16(6):1579-81. DMS30HQ RU https://pubmed.ncbi.nlm.nih.gov/16386418 DMS30HQ DI DMS30HQ DMS30HQ DN 4-(isoquinolin-5-yl)-N-o-tolylphthalazin-1-amine DMS30HQ MI TT1VAUK DMS30HQ MN VEGFR1 messenger RNA (VEGFR1 mRNA) DMS30HQ MT DTT DMS30HQ MA Inhibitor DMS30HQ RN Arylphthalazines. Part 2: 1-(Isoquinolin-5-yl)-4-arylamino phthalazines as potent inhibitors of VEGF receptors I and II. Bioorg Med Chem Lett. 2006 Mar 15;16(6):1579-81. DMS30HQ RU https://pubmed.ncbi.nlm.nih.gov/16386418 DMQG57D DI DMQG57D DMQG57D DN 4-(mesityloxy)-2-(trifluoromethyl)benzonitrile DMQG57D MI TTKPW01 DMQG57D MN Androgen receptor messenger RNA (AR mRNA) DMQG57D MT DTT DMQG57D MA Inhibitor DMQG57D RN Diphenyl ethers as androgen receptor antagonists for the topical suppression of sebum production. Bioorg Med Chem Lett. 2009 Apr 15;19(8):2176-8. DMQG57D RU https://pubmed.ncbi.nlm.nih.gov/19286380 DMAI3NZ DI DMAI3NZ DMAI3NZ DN 4-(mesitylthio)-2-(trifluoromethyl)benzonitrile DMAI3NZ MI TTKPW01 DMAI3NZ MN Androgen receptor messenger RNA (AR mRNA) DMAI3NZ MT DTT DMAI3NZ MA Inhibitor DMAI3NZ RN 4-(Alkylthio)- and 4-(arylthio)-benzonitrile derivatives as androgen receptor antagonists for the topical suppression of sebum production. Bioorg Med Chem Lett. 2009 Mar 1;19(5):1310-3. DMAI3NZ RU https://pubmed.ncbi.nlm.nih.gov/19201190 DM1XK68 DI DM1XK68 DM1XK68 DN 4-(mesitylthio)-2-methoxybenzonitrile DM1XK68 MI TTKPW01 DM1XK68 MN Androgen receptor messenger RNA (AR mRNA) DM1XK68 MT DTT DM1XK68 MA Inhibitor DM1XK68 RN 4-(Alkylthio)- and 4-(arylthio)-benzonitrile derivatives as androgen receptor antagonists for the topical suppression of sebum production. Bioorg Med Chem Lett. 2009 Mar 1;19(5):1310-3. DM1XK68 RU https://pubmed.ncbi.nlm.nih.gov/19201190 DMQCMFU DI DMQCMFU DMQCMFU DN 4-(methyl(4-phenylthiazol-2-yl)amino)phenol DMQCMFU MI TTHY57M DMQCMFU MN Matrix metalloproteinase-13 (MMP-13) DMQCMFU MT DTT DMQCMFU MA Inhibitor DMQCMFU RN High throughput screening of potentially selective MMP-13 exosite inhibitors utilizing a triple-helical FRET substrate. Bioorg Med Chem. 2009 Feb 1;17(3):990-1005. DMQCMFU RU https://pubmed.ncbi.nlm.nih.gov/18358729 DM3TF9Y DI DM3TF9Y DM3TF9Y DN 4-(methyl(nonyl)amino)-N-(quinolin-3-yl)benzamide DM3TF9Y MI TTMI6F5 DM3TF9Y MN Transient receptor potential cation channel V1 (TRPV1) DM3TF9Y MT DTT DM3TF9Y MA Inhibitor DM3TF9Y RN N-pyridin-3-yl- and N-quinolin-3-yl-benzamides: modulators of human vanilloid receptor 1 (TRPV1). Bioorg Med Chem Lett. 2008 Apr 15;18(8):2730-4. DM3TF9Y RU https://pubmed.ncbi.nlm.nih.gov/18359227 DM1I0TA DI DM1I0TA DM1I0TA DN 4-(methyl(octyl)amino)-N-(quinolin-3-yl)benzamide DM1I0TA MI TTMI6F5 DM1I0TA MN Transient receptor potential cation channel V1 (TRPV1) DM1I0TA MT DTT DM1I0TA MA Inhibitor DM1I0TA RN N-pyridin-3-yl- and N-quinolin-3-yl-benzamides: modulators of human vanilloid receptor 1 (TRPV1). Bioorg Med Chem Lett. 2008 Apr 15;18(8):2730-4. DM1I0TA RU https://pubmed.ncbi.nlm.nih.gov/18359227 DMF3O10 DI DMF3O10 DMF3O10 DN 4-(methylamino)naphthalen-1-ol DMF3O10 MI TTZJYKH DMF3O10 MN Indoleamine 2,3-dioxygenase 1 (IDO1) DMF3O10 MT DTT DMF3O10 MA Inhibitor DMF3O10 RN Rational design of indoleamine 2,3-dioxygenase inhibitors. J Med Chem. 2010 Feb 11;53(3):1172-89. DMF3O10 RU https://pubmed.ncbi.nlm.nih.gov/20055453 DM4BPL1 DI DM4BPL1 DM4BPL1 DN 4-(Methylhydrazino)-3-pyridinesulfonamide DM4BPL1 MI TTHQPL7 DM4BPL1 MN Carbonic anhydrase I (CA-I) DM4BPL1 MT DTT DM4BPL1 MA Inhibitor DM4BPL1 RN Carbonic anhydrase inhibitors: synthesis and inhibition of the human cytosolic isozymes I and II and transmembrane isozymes IX, XII (cancer-associa... Eur J Med Chem. 2010 Jun;45(6):2396-404. DM4BPL1 RU https://pubmed.ncbi.nlm.nih.gov/20202722 DM4BPL1 DI DM4BPL1 DM4BPL1 DN 4-(Methylhydrazino)-3-pyridinesulfonamide DM4BPL1 MI TTANPDJ DM4BPL1 MN Carbonic anhydrase II (CA-II) DM4BPL1 MT DTT DM4BPL1 MA Inhibitor DM4BPL1 RN Carbonic anhydrase inhibitors: synthesis and inhibition of the human cytosolic isozymes I and II and transmembrane isozymes IX, XII (cancer-associa... Eur J Med Chem. 2010 Jun;45(6):2396-404. DM4BPL1 RU https://pubmed.ncbi.nlm.nih.gov/20202722 DM4BPL1 DI DM4BPL1 DM4BPL1 DN 4-(Methylhydrazino)-3-pyridinesulfonamide DM4BPL1 MI TT2LVK8 DM4BPL1 MN Carbonic anhydrase IX (CA-IX) DM4BPL1 MT DTT DM4BPL1 MA Inhibitor DM4BPL1 RN Carbonic anhydrase inhibitors: synthesis and inhibition of the human cytosolic isozymes I and II and transmembrane isozymes IX, XII (cancer-associa... Eur J Med Chem. 2010 Jun;45(6):2396-404. DM4BPL1 RU https://pubmed.ncbi.nlm.nih.gov/20202722 DM4BPL1 DI DM4BPL1 DM4BPL1 DN 4-(Methylhydrazino)-3-pyridinesulfonamide DM4BPL1 MI TTSYM0R DM4BPL1 MN Carbonic anhydrase XII (CA-XII) DM4BPL1 MT DTT DM4BPL1 MA Inhibitor DM4BPL1 RN Carbonic anhydrase inhibitors: synthesis and inhibition of the human cytosolic isozymes I and II and transmembrane isozymes IX, XII (cancer-associa... Eur J Med Chem. 2010 Jun;45(6):2396-404. DM4BPL1 RU https://pubmed.ncbi.nlm.nih.gov/20202722 DM4BPL1 DI DM4BPL1 DM4BPL1 DN 4-(Methylhydrazino)-3-pyridinesulfonamide DM4BPL1 MI TTEYTKG DM4BPL1 MN Carbonic anhydrase XIV (CA-XIV) DM4BPL1 MT DTT DM4BPL1 MA Inhibitor DM4BPL1 RN Carbonic anhydrase inhibitors: synthesis and inhibition of the human cytosolic isozymes I and II and transmembrane isozymes IX, XII (cancer-associa... Eur J Med Chem. 2010 Jun;45(6):2396-404. DM4BPL1 RU https://pubmed.ncbi.nlm.nih.gov/20202722 DM8BWZO DI DM8BWZO DM8BWZO DN 4-(m-tolyloxy)-2-(trifluoromethyl)benzonitrile DM8BWZO MI TTKPW01 DM8BWZO MN Androgen receptor messenger RNA (AR mRNA) DM8BWZO MT DTT DM8BWZO MA Inhibitor DM8BWZO RN Diphenyl ethers as androgen receptor antagonists for the topical suppression of sebum production. Bioorg Med Chem Lett. 2009 Apr 15;19(8):2176-8. DM8BWZO RU https://pubmed.ncbi.nlm.nih.gov/19286380 DMI5XB1 DI DMI5XB1 DMI5XB1 DN 4-(Naphthalene-1-sulfonyl)-phenylamine DMI5XB1 MI TTJS8PY DMI5XB1 MN 5-HT 6 receptor (HTR6) DMI5XB1 MT DTT DMI5XB1 MA Inhibitor DMI5XB1 RN 1-(1-Naphthyl)piperazine as a novel template for 5-HT6 serotonin receptor ligands. Bioorg Med Chem Lett. 2005 Mar 15;15(6):1707-11. DMI5XB1 RU https://pubmed.ncbi.nlm.nih.gov/15745826 DMADWTI DI DMADWTI DMADWTI DN 4-(N-Methyl-hydrazino)-benzenesulfonamide DMADWTI MI TTANPDJ DMADWTI MN Carbonic anhydrase II (CA-II) DMADWTI MT DTT DMADWTI MA Inhibitor DMADWTI RN Carbonic anhydrase inhibitors. Inhibition of the transmembrane isozyme XII with sulfonamides-a new target for the design of antitumor and antiglauc... Bioorg Med Chem Lett. 2005 Feb 15;15(4):963-9. DMADWTI RU https://pubmed.ncbi.nlm.nih.gov/15686894 DMADWTI DI DMADWTI DMADWTI DN 4-(N-Methyl-hydrazino)-benzenesulfonamide DMADWTI MI TTSYM0R DMADWTI MN Carbonic anhydrase XII (CA-XII) DMADWTI MT DTT DMADWTI MA Inhibitor DMADWTI RN Carbonic anhydrase inhibitors. Inhibition of the transmembrane isozyme XII with sulfonamides-a new target for the design of antitumor and antiglauc... Bioorg Med Chem Lett. 2005 Feb 15;15(4):963-9. DMADWTI RU https://pubmed.ncbi.nlm.nih.gov/15686894 DMYCV8E DI DMYCV8E DMYCV8E DN 4-(N-Oxide-2-pyridylthio)pyridine-3-sulfonamide DMYCV8E MI TTHQPL7 DMYCV8E MN Carbonic anhydrase I (CA-I) DMYCV8E MT DTT DMYCV8E MA Inhibitor DMYCV8E RN Carbonic anhydrase inhibitors: synthesis and inhibition of the human cytosolic isozymes I and II and transmembrane isozymes IX, XII (cancer-associa... Eur J Med Chem. 2010 Jun;45(6):2396-404. DMYCV8E RU https://pubmed.ncbi.nlm.nih.gov/20202722 DMYCV8E DI DMYCV8E DMYCV8E DN 4-(N-Oxide-2-pyridylthio)pyridine-3-sulfonamide DMYCV8E MI TTANPDJ DMYCV8E MN Carbonic anhydrase II (CA-II) DMYCV8E MT DTT DMYCV8E MA Inhibitor DMYCV8E RN Carbonic anhydrase inhibitors: synthesis and inhibition of the human cytosolic isozymes I and II and transmembrane isozymes IX, XII (cancer-associa... Eur J Med Chem. 2010 Jun;45(6):2396-404. DMYCV8E RU https://pubmed.ncbi.nlm.nih.gov/20202722 DMYCV8E DI DMYCV8E DMYCV8E DN 4-(N-Oxide-2-pyridylthio)pyridine-3-sulfonamide DMYCV8E MI TT2LVK8 DMYCV8E MN Carbonic anhydrase IX (CA-IX) DMYCV8E MT DTT DMYCV8E MA Inhibitor DMYCV8E RN Carbonic anhydrase inhibitors: synthesis and inhibition of the human cytosolic isozymes I and II and transmembrane isozymes IX, XII (cancer-associa... Eur J Med Chem. 2010 Jun;45(6):2396-404. DMYCV8E RU https://pubmed.ncbi.nlm.nih.gov/20202722 DMYCV8E DI DMYCV8E DMYCV8E DN 4-(N-Oxide-2-pyridylthio)pyridine-3-sulfonamide DMYCV8E MI TTSYM0R DMYCV8E MN Carbonic anhydrase XII (CA-XII) DMYCV8E MT DTT DMYCV8E MA Inhibitor DMYCV8E RN Carbonic anhydrase inhibitors: synthesis and inhibition of the human cytosolic isozymes I and II and transmembrane isozymes IX, XII (cancer-associa... Eur J Med Chem. 2010 Jun;45(6):2396-404. DMYCV8E RU https://pubmed.ncbi.nlm.nih.gov/20202722 DMP43HI DI DMP43HI DMP43HI DN 4-(n-propyl)amino-3-nitrobenzoic acid DMP43HI MI TT8WFXV DMP43HI MN Hydroxycarboxylic acid receptor 3 (HCAR3) DMP43HI MT DTT DMP43HI MA Agonist DMP43HI RN 3-Nitro-4-amino benzoic acids and 6-amino nicotinic acids are highly selective agonists of GPR109b. Bioorg Med Chem Lett. 2007 Dec 1;17(23):6619-22. DMP43HI RU https://pubmed.ncbi.nlm.nih.gov/17931863 DM8I4B9 DI DM8I4B9 DM8I4B9 DN 4-(o-tolyloxy)-2-(trifluoromethyl)benzonitrile DM8I4B9 MI TTKPW01 DM8I4B9 MN Androgen receptor messenger RNA (AR mRNA) DM8I4B9 MT DTT DM8I4B9 MA Inhibitor DM8I4B9 RN Diphenyl ethers as androgen receptor antagonists for the topical suppression of sebum production. Bioorg Med Chem Lett. 2009 Apr 15;19(8):2176-8. DM8I4B9 RU https://pubmed.ncbi.nlm.nih.gov/19286380 DM85XP6 DI DM85XP6 DM85XP6 DN 4-(o-tolylthio)-2-(trifluoromethyl)benzonitrile DM85XP6 MI TTKPW01 DM85XP6 MN Androgen receptor messenger RNA (AR mRNA) DM85XP6 MT DTT DM85XP6 MA Inhibitor DM85XP6 RN 4-(Alkylthio)- and 4-(arylthio)-benzonitrile derivatives as androgen receptor antagonists for the topical suppression of sebum production. Bioorg Med Chem Lett. 2009 Mar 1;19(5):1310-3. DM85XP6 RU https://pubmed.ncbi.nlm.nih.gov/19201190 DMHIDY6 DI DMHIDY6 DMHIDY6 DN 4-(Pent-3-ylamino)-1-naphthol DMHIDY6 MI TTZJYKH DMHIDY6 MN Indoleamine 2,3-dioxygenase 1 (IDO1) DMHIDY6 MT DTT DMHIDY6 MA Inhibitor DMHIDY6 RN Rational design of indoleamine 2,3-dioxygenase inhibitors. J Med Chem. 2010 Feb 11;53(3):1172-89. DMHIDY6 RU https://pubmed.ncbi.nlm.nih.gov/20055453 DM54MOP DI DM54MOP DM54MOP DN 4-(phenyldiazenyl)-1H-pyrazole-3,5-diamine DM54MOP MI TTAMQ62 DM54MOP MN Cyclin A2 (CCNA2) DM54MOP MT DTT DM54MOP MA Inhibitor DM54MOP RN 4-arylazo-3,5-diamino-1H-pyrazole CDK inhibitors: SAR study, crystal structure in complex with CDK2, selectivity, and cellular effects. J Med Chem. 2006 Nov 2;49(22):6500-9. DM54MOP RU https://pubmed.ncbi.nlm.nih.gov/17064068 DM54MOP DI DM54MOP DM54MOP DN 4-(phenyldiazenyl)-1H-pyrazole-3,5-diamine DM54MOP MI TT1LVF2 DM54MOP MN Cyclin-dependent kinase 9 (CDK9) DM54MOP MT DTT DM54MOP MA Inhibitor DM54MOP RN 4-arylazo-3,5-diamino-1H-pyrazole CDK inhibitors: SAR study, crystal structure in complex with CDK2, selectivity, and cellular effects. J Med Chem. 2006 Nov 2;49(22):6500-9. DM54MOP RU https://pubmed.ncbi.nlm.nih.gov/17064068 DMM1RCS DI DMM1RCS DMM1RCS DN 4-(piperazin-1-yl)-1H-indole DMM1RCS MI TTJS8PY DMM1RCS MN 5-HT 6 receptor (HTR6) DMM1RCS MT DTT DMM1RCS MA Inhibitor DMM1RCS RN Binding of amine-substituted N1-benzenesulfonylindoles at human 5-HT6 serotonin receptors. Bioorg Med Chem Lett. 2005 Dec 1;15(23):5298-302. DMM1RCS RU https://pubmed.ncbi.nlm.nih.gov/16183286 DM1HM3F DI DM1HM3F DM1HM3F DN 4-(piperazin-1-yl)-3-tosyl-1H-indazole DM1HM3F MI TTJS8PY DM1HM3F MN 5-HT 6 receptor (HTR6) DM1HM3F MT DTT DM1HM3F MA Inhibitor DM1HM3F RN 5-Piperazinyl-3-sulfonylindazoles as potent and selective 5-hydroxytryptamine-6 antagonists. J Med Chem. 2010 Nov 11;53(21):7639-46. DM1HM3F RU https://pubmed.ncbi.nlm.nih.gov/20932009 DMTNVFZ DI DMTNVFZ DMTNVFZ DN 4-(piperazin-1-yl)-7H-pyrrolo[2,3-d]pyrimidine DMTNVFZ MI TTWJBZ5 DMTNVFZ MN 5-HT 2C receptor (HTR2C) DMTNVFZ MT DTT DMTNVFZ MA Inhibitor DMTNVFZ RN Design and synthesis of orally-active and selective azaindane 5HT2c agonist for the treatment of obesity. Bioorg Med Chem Lett. 2010 Jan 1;20(1):266-71. DMTNVFZ RU https://pubmed.ncbi.nlm.nih.gov/19914063 DMNM8VY DI DMNM8VY DMNM8VY DN 4-(piperazin-1-yl)furo[3,2-c]pyridine DMNM8VY MI TTWJBZ5 DMNM8VY MN 5-HT 2C receptor (HTR2C) DMNM8VY MT DTT DMNM8VY MA Inhibitor DMNM8VY RN Design and synthesis of orally-active and selective azaindane 5HT2c agonist for the treatment of obesity. Bioorg Med Chem Lett. 2010 Jan 1;20(1):266-71. DMNM8VY RU https://pubmed.ncbi.nlm.nih.gov/19914063 DMNU2RM DI DMNU2RM DMNU2RM DN 4-(piperazin-1-yl)thieno[2,3-d]pyrimidine DMNU2RM MI TTWJBZ5 DMNU2RM MN 5-HT 2C receptor (HTR2C) DMNU2RM MT DTT DMNU2RM MA Inhibitor DMNU2RM RN Design and synthesis of orally-active and selective azaindane 5HT2c agonist for the treatment of obesity. Bioorg Med Chem Lett. 2010 Jan 1;20(1):266-71. DMNU2RM RU https://pubmed.ncbi.nlm.nih.gov/19914063 DMJGTS7 DI DMJGTS7 DMJGTS7 DN 4-(piperazin-1-yl)thieno[3,2-c]pyridine DMJGTS7 MI TTWJBZ5 DMJGTS7 MN 5-HT 2C receptor (HTR2C) DMJGTS7 MT DTT DMJGTS7 MA Inhibitor DMJGTS7 RN Design and synthesis of orally-active and selective azaindane 5HT2c agonist for the treatment of obesity. Bioorg Med Chem Lett. 2010 Jan 1;20(1):266-71. DMJGTS7 RU https://pubmed.ncbi.nlm.nih.gov/19914063 DM2KAG5 DI DM2KAG5 DM2KAG5 DN 4-(piperazin-1-yl)thieno[3,2-d]pyrimidine DM2KAG5 MI TTWJBZ5 DM2KAG5 MN 5-HT 2C receptor (HTR2C) DM2KAG5 MT DTT DM2KAG5 MA Inhibitor DM2KAG5 RN Design and synthesis of orally-active and selective azaindane 5HT2c agonist for the treatment of obesity. Bioorg Med Chem Lett. 2010 Jan 1;20(1):266-71. DM2KAG5 RU https://pubmed.ncbi.nlm.nih.gov/19914063 DMEAZFJ DI DMEAZFJ DMEAZFJ DN 4-(propylamino)naphthalen-1-ol DMEAZFJ MI TTZJYKH DMEAZFJ MN Indoleamine 2,3-dioxygenase 1 (IDO1) DMEAZFJ MT DTT DMEAZFJ MA Inhibitor DMEAZFJ RN Rational design of indoleamine 2,3-dioxygenase inhibitors. J Med Chem. 2010 Feb 11;53(3):1172-89. DMEAZFJ RU https://pubmed.ncbi.nlm.nih.gov/20055453 DM8BZQ3 DI DM8BZQ3 DM8BZQ3 DN 4-(propylthio)-2-(trifluoromethyl)benzonitrile DM8BZQ3 MI TTKPW01 DM8BZQ3 MN Androgen receptor messenger RNA (AR mRNA) DM8BZQ3 MT DTT DM8BZQ3 MA Inhibitor DM8BZQ3 RN 4-(Alkylthio)- and 4-(arylthio)-benzonitrile derivatives as androgen receptor antagonists for the topical suppression of sebum production. Bioorg Med Chem Lett. 2009 Mar 1;19(5):1310-3. DM8BZQ3 RU https://pubmed.ncbi.nlm.nih.gov/19201190 DM8M0N9 DI DM8M0N9 DM8M0N9 DN 4'-(p-toluenesulfonamide)-3,4-dihydroxy chalcone DM8M0N9 MI TTXWASR DM8M0N9 MN Intestinal maltase-glucoamylase (MGAM) DM8M0N9 MT DTT DM8M0N9 MA Inhibitor DM8M0N9 RN Sulfonamide chalcone as a new class of alpha-glucosidase inhibitors. Bioorg Med Chem Lett. 2005 Dec 15;15(24):5514-6. DM8M0N9 RU https://pubmed.ncbi.nlm.nih.gov/16202584 DMRFWE1 DI DMRFWE1 DMRFWE1 DN 4'-(p-Toluenesulfonamide)-4-hydroxychalcone DMRFWE1 MI TTULVH8 DMRFWE1 MN Tyrosinase (TYR) DMRFWE1 MT DTT DMRFWE1 MA Inhibitor DMRFWE1 RN Evaluation of anti-pigmentary effect of synthetic sulfonylamino chalcone. Eur J Med Chem. 2010 May;45(5):2010-7. DMRFWE1 RU https://pubmed.ncbi.nlm.nih.gov/20149498 DMQA0EJ DI DMQA0EJ DMQA0EJ DN 4-(p-toluidino)-3-isopropylnaphthalene-1,2-dione DMQA0EJ MI TTLZS4Q DMQA0EJ MN M-phase inducer phosphatase 1 (MPIP1) DMQA0EJ MT DTT DMQA0EJ MA Inhibitor DMQA0EJ RN Synthesis of miltirone analogues as inhibitors of Cdc25 phosphatases. Bioorg Med Chem Lett. 2006 Apr 1;16(7):1905-8. DMQA0EJ RU https://pubmed.ncbi.nlm.nih.gov/16434190 DMQA0EJ DI DMQA0EJ DMQA0EJ DN 4-(p-toluidino)-3-isopropylnaphthalene-1,2-dione DMQA0EJ MI TTR0SWN DMQA0EJ MN M-phase inducer phosphatase 2 (MPIP2) DMQA0EJ MT DTT DMQA0EJ MA Inhibitor DMQA0EJ RN Synthesis of miltirone analogues as inhibitors of Cdc25 phosphatases. Bioorg Med Chem Lett. 2006 Apr 1;16(7):1905-8. DMQA0EJ RU https://pubmed.ncbi.nlm.nih.gov/16434190 DMQA0EJ DI DMQA0EJ DMQA0EJ DN 4-(p-toluidino)-3-isopropylnaphthalene-1,2-dione DMQA0EJ MI TTELIN2 DMQA0EJ MN PTPN1 messenger RNA (PTPN1 mRNA) DMQA0EJ MT DTT DMQA0EJ MA Inhibitor DMQA0EJ RN Synthesis of miltirone analogues as inhibitors of Cdc25 phosphatases. Bioorg Med Chem Lett. 2006 Apr 1;16(7):1905-8. DMQA0EJ RU https://pubmed.ncbi.nlm.nih.gov/16434190 DMIOQJD DI DMIOQJD DMIOQJD DN 4-(p-Tolyl)spiro[chromene-2,4'-piperidine] DMIOQJD MI TT27RFC DMIOQJD MN Opioid receptor delta (OPRD1) DMIOQJD MT DTT DMIOQJD MA Inhibitor DMIOQJD RN Potent, orally bioavailable delta opioid receptor agonists for the treatment of pain: discovery of N,N-diethyl-4-(5-hydroxyspiro[chromene-2,4'-pipe... J Med Chem. 2008 Oct 9;51(19):5893-6. DMIOQJD RU https://pubmed.ncbi.nlm.nih.gov/18788723 DMIOQJD DI DMIOQJD DMIOQJD DN 4-(p-Tolyl)spiro[chromene-2,4'-piperidine] DMIOQJD MI TTQW87Y DMIOQJD MN Opioid receptor kappa (OPRK1) DMIOQJD MT DTT DMIOQJD MA Inhibitor DMIOQJD RN Potent, orally bioavailable delta opioid receptor agonists for the treatment of pain: discovery of N,N-diethyl-4-(5-hydroxyspiro[chromene-2,4'-pipe... J Med Chem. 2008 Oct 9;51(19):5893-6. DMIOQJD RU https://pubmed.ncbi.nlm.nih.gov/18788723 DMIOQJD DI DMIOQJD DMIOQJD DN 4-(p-Tolyl)spiro[chromene-2,4'-piperidine] DMIOQJD MI TTQ6VDM DMIOQJD MN Voltage-gated potassium channel Kv11.1 (KCNH2) DMIOQJD MT DTT DMIOQJD MA Inhibitor DMIOQJD RN Potent, orally bioavailable delta opioid receptor agonists for the treatment of pain: discovery of N,N-diethyl-4-(5-hydroxyspiro[chromene-2,4'-pipe... J Med Chem. 2008 Oct 9;51(19):5893-6. DMIOQJD RU https://pubmed.ncbi.nlm.nih.gov/18788723 DMXK56P DI DMXK56P DMXK56P DN 4-(p-tolyloxy)-2-(trifluoromethyl)benzonitrile DMXK56P MI TTKPW01 DMXK56P MN Androgen receptor messenger RNA (AR mRNA) DMXK56P MT DTT DMXK56P MA Inhibitor DMXK56P RN Diphenyl ethers as androgen receptor antagonists for the topical suppression of sebum production. Bioorg Med Chem Lett. 2009 Apr 15;19(8):2176-8. DMXK56P RU https://pubmed.ncbi.nlm.nih.gov/19286380 DMZ0H5X DI DMZ0H5X DMZ0H5X DN 4'-(Pyridin-4-ylmethyl)biphenyl-3,4-diamine DMZ0H5X MI TTIQUX7 DMZ0H5X MN Steroid 11-beta-hydroxylase (CYP11B1) DMZ0H5X MT DTT DMZ0H5X MA Inhibitor DMZ0H5X RN Replacement of imidazolyl by pyridyl in biphenylmethylenes results in selective CYP17 and dual CYP17/CYP11B1 inhibitors for the treatment of prosta... J Med Chem. 2010 Aug 12;53(15):5749-58. DMZ0H5X RU https://pubmed.ncbi.nlm.nih.gov/20684610 DMZ0H5X DI DMZ0H5X DMZ0H5X DN 4'-(Pyridin-4-ylmethyl)biphenyl-3,4-diamine DMZ0H5X MI TTRA5BZ DMZ0H5X MN Steroid 17-alpha-monooxygenase (S17AH) DMZ0H5X MT DTT DMZ0H5X MA Inhibitor DMZ0H5X RN Replacement of imidazolyl by pyridyl in biphenylmethylenes results in selective CYP17 and dual CYP17/CYP11B1 inhibitors for the treatment of prosta... J Med Chem. 2010 Aug 12;53(15):5749-58. DMZ0H5X RU https://pubmed.ncbi.nlm.nih.gov/20684610 DM6Z5EK DI DM6Z5EK DM6Z5EK DN 4'-(Pyridin-4-ylmethyl)biphenyl-3,4-diol DM6Z5EK MI TTSZLWK DM6Z5EK MN Aromatase (CYP19A1) DM6Z5EK MT DTT DM6Z5EK MA Inhibitor DM6Z5EK RN Replacement of imidazolyl by pyridyl in biphenylmethylenes results in selective CYP17 and dual CYP17/CYP11B1 inhibitors for the treatment of prosta... J Med Chem. 2010 Aug 12;53(15):5749-58. DM6Z5EK RU https://pubmed.ncbi.nlm.nih.gov/20684610 DM6Z5EK DI DM6Z5EK DM6Z5EK DN 4'-(Pyridin-4-ylmethyl)biphenyl-3,4-diol DM6Z5EK MI TTIQUX7 DM6Z5EK MN Steroid 11-beta-hydroxylase (CYP11B1) DM6Z5EK MT DTT DM6Z5EK MA Inhibitor DM6Z5EK RN Replacement of imidazolyl by pyridyl in biphenylmethylenes results in selective CYP17 and dual CYP17/CYP11B1 inhibitors for the treatment of prosta... J Med Chem. 2010 Aug 12;53(15):5749-58. DM6Z5EK RU https://pubmed.ncbi.nlm.nih.gov/20684610 DM6Z5EK DI DM6Z5EK DM6Z5EK DN 4'-(Pyridin-4-ylmethyl)biphenyl-3,4-diol DM6Z5EK MI TTRA5BZ DM6Z5EK MN Steroid 17-alpha-monooxygenase (S17AH) DM6Z5EK MT DTT DM6Z5EK MA Inhibitor DM6Z5EK RN Replacement of imidazolyl by pyridyl in biphenylmethylenes results in selective CYP17 and dual CYP17/CYP11B1 inhibitors for the treatment of prosta... J Med Chem. 2010 Aug 12;53(15):5749-58. DM6Z5EK RU https://pubmed.ncbi.nlm.nih.gov/20684610 DMR8O1B DI DMR8O1B DMR8O1B DN 4'-(Pyridin-4-ylmethyl)biphenyl-3-amine DMR8O1B MI TTSZLWK DMR8O1B MN Aromatase (CYP19A1) DMR8O1B MT DTT DMR8O1B MA Inhibitor DMR8O1B RN Replacement of imidazolyl by pyridyl in biphenylmethylenes results in selective CYP17 and dual CYP17/CYP11B1 inhibitors for the treatment of prosta... J Med Chem. 2010 Aug 12;53(15):5749-58. DMR8O1B RU https://pubmed.ncbi.nlm.nih.gov/20684610 DMR8O1B DI DMR8O1B DMR8O1B DN 4'-(Pyridin-4-ylmethyl)biphenyl-3-amine DMR8O1B MI TTIQUX7 DMR8O1B MN Steroid 11-beta-hydroxylase (CYP11B1) DMR8O1B MT DTT DMR8O1B MA Inhibitor DMR8O1B RN Replacement of imidazolyl by pyridyl in biphenylmethylenes results in selective CYP17 and dual CYP17/CYP11B1 inhibitors for the treatment of prosta... J Med Chem. 2010 Aug 12;53(15):5749-58. DMR8O1B RU https://pubmed.ncbi.nlm.nih.gov/20684610 DMR8O1B DI DMR8O1B DMR8O1B DN 4'-(Pyridin-4-ylmethyl)biphenyl-3-amine DMR8O1B MI TTRA5BZ DMR8O1B MN Steroid 17-alpha-monooxygenase (S17AH) DMR8O1B MT DTT DMR8O1B MA Inhibitor DMR8O1B RN Replacement of imidazolyl by pyridyl in biphenylmethylenes results in selective CYP17 and dual CYP17/CYP11B1 inhibitors for the treatment of prosta... J Med Chem. 2010 Aug 12;53(15):5749-58. DMR8O1B RU https://pubmed.ncbi.nlm.nih.gov/20684610 DM8HXYS DI DM8HXYS DM8HXYS DN 4'-(Pyridin-4-ylmethyl)biphenyl-4-amine DM8HXYS MI TTIQUX7 DM8HXYS MN Steroid 11-beta-hydroxylase (CYP11B1) DM8HXYS MT DTT DM8HXYS MA Inhibitor DM8HXYS RN Replacement of imidazolyl by pyridyl in biphenylmethylenes results in selective CYP17 and dual CYP17/CYP11B1 inhibitors for the treatment of prosta... J Med Chem. 2010 Aug 12;53(15):5749-58. DM8HXYS RU https://pubmed.ncbi.nlm.nih.gov/20684610 DM8HXYS DI DM8HXYS DM8HXYS DN 4'-(Pyridin-4-ylmethyl)biphenyl-4-amine DM8HXYS MI TTRA5BZ DM8HXYS MN Steroid 17-alpha-monooxygenase (S17AH) DM8HXYS MT DTT DM8HXYS MA Inhibitor DM8HXYS RN Replacement of imidazolyl by pyridyl in biphenylmethylenes results in selective CYP17 and dual CYP17/CYP11B1 inhibitors for the treatment of prosta... J Med Chem. 2010 Aug 12;53(15):5749-58. DM8HXYS RU https://pubmed.ncbi.nlm.nih.gov/20684610 DMYXMT6 DI DMYXMT6 DMYXMT6 DN 4'-(Pyridin-4-ylmethyl)biphenyl-4-carboxamide DMYXMT6 MI TTRA5BZ DMYXMT6 MN Steroid 17-alpha-monooxygenase (S17AH) DMYXMT6 MT DTT DMYXMT6 MA Inhibitor DMYXMT6 RN Replacement of imidazolyl by pyridyl in biphenylmethylenes results in selective CYP17 and dual CYP17/CYP11B1 inhibitors for the treatment of prosta... J Med Chem. 2010 Aug 12;53(15):5749-58. DMYXMT6 RU https://pubmed.ncbi.nlm.nih.gov/20684610 DM4YFU5 DI DM4YFU5 DM4YFU5 DN 4-(Quinolin-3-yl)-N-p-tolylpyrimidin-2-amine DM4YFU5 MI TTH6V3D DM4YFU5 MN Cyclin-dependent kinase 1 (CDK1) DM4YFU5 MT DTT DM4YFU5 MA Inhibitor DM4YFU5 RN Synthesis and cytotoxic activity of 2-methylimidazo[1,2-a]pyridine- and quinoline-substituted 2-aminopyrimidine derivatives. Eur J Med Chem. 2010 Jan;45(1):379-86. DM4YFU5 RU https://pubmed.ncbi.nlm.nih.gov/19879023 DM4YFU5 DI DM4YFU5 DM4YFU5 DN 4-(Quinolin-3-yl)-N-p-tolylpyrimidin-2-amine DM4YFU5 MI TT9P6OW DM4YFU5 MN G2/mitotic-specific cyclin B1 (CCNB1) DM4YFU5 MT DTT DM4YFU5 MA Inhibitor DM4YFU5 RN Synthesis and cytotoxic activity of 2-methylimidazo[1,2-a]pyridine- and quinoline-substituted 2-aminopyrimidine derivatives. Eur J Med Chem. 2010 Jan;45(1):379-86. DM4YFU5 RU https://pubmed.ncbi.nlm.nih.gov/19879023 DMDW3SX DI DMDW3SX DMDW3SX DN 4-(Quinolin-4-yl)-N-p-tolylpyrimidin-2-amine DMDW3SX MI TTH6V3D DMDW3SX MN Cyclin-dependent kinase 1 (CDK1) DMDW3SX MT DTT DMDW3SX MA Inhibitor DMDW3SX RN Synthesis and cytotoxic activity of 2-methylimidazo[1,2-a]pyridine- and quinoline-substituted 2-aminopyrimidine derivatives. Eur J Med Chem. 2010 Jan;45(1):379-86. DMDW3SX RU https://pubmed.ncbi.nlm.nih.gov/19879023 DMDW3SX DI DMDW3SX DMDW3SX DN 4-(Quinolin-4-yl)-N-p-tolylpyrimidin-2-amine DMDW3SX MI TT9P6OW DMDW3SX MN G2/mitotic-specific cyclin B1 (CCNB1) DMDW3SX MT DTT DMDW3SX MA Inhibitor DMDW3SX RN Synthesis and cytotoxic activity of 2-methylimidazo[1,2-a]pyridine- and quinoline-substituted 2-aminopyrimidine derivatives. Eur J Med Chem. 2010 Jan;45(1):379-86. DMDW3SX RU https://pubmed.ncbi.nlm.nih.gov/19879023 DMPNXFA DI DMPNXFA DMPNXFA DN 4-(Quinolinoxy)-3-pyridinesulfonamide DMPNXFA MI TTHQPL7 DMPNXFA MN Carbonic anhydrase I (CA-I) DMPNXFA MT DTT DMPNXFA MA Inhibitor DMPNXFA RN Carbonic anhydrase inhibitors: synthesis and inhibition of the human cytosolic isozymes I and II and transmembrane isozymes IX, XII (cancer-associa... Eur J Med Chem. 2010 Jun;45(6):2396-404. DMPNXFA RU https://pubmed.ncbi.nlm.nih.gov/20202722 DMPNXFA DI DMPNXFA DMPNXFA DN 4-(Quinolinoxy)-3-pyridinesulfonamide DMPNXFA MI TTANPDJ DMPNXFA MN Carbonic anhydrase II (CA-II) DMPNXFA MT DTT DMPNXFA MA Inhibitor DMPNXFA RN Carbonic anhydrase inhibitors: synthesis and inhibition of the human cytosolic isozymes I and II and transmembrane isozymes IX, XII (cancer-associa... Eur J Med Chem. 2010 Jun;45(6):2396-404. DMPNXFA RU https://pubmed.ncbi.nlm.nih.gov/20202722 DMPNXFA DI DMPNXFA DMPNXFA DN 4-(Quinolinoxy)-3-pyridinesulfonamide DMPNXFA MI TT2LVK8 DMPNXFA MN Carbonic anhydrase IX (CA-IX) DMPNXFA MT DTT DMPNXFA MA Inhibitor DMPNXFA RN Carbonic anhydrase inhibitors: synthesis and inhibition of the human cytosolic isozymes I and II and transmembrane isozymes IX, XII (cancer-associa... Eur J Med Chem. 2010 Jun;45(6):2396-404. DMPNXFA RU https://pubmed.ncbi.nlm.nih.gov/20202722 DMPNXFA DI DMPNXFA DMPNXFA DN 4-(Quinolinoxy)-3-pyridinesulfonamide DMPNXFA MI TTSYM0R DMPNXFA MN Carbonic anhydrase XII (CA-XII) DMPNXFA MT DTT DMPNXFA MA Inhibitor DMPNXFA RN Carbonic anhydrase inhibitors: synthesis and inhibition of the human cytosolic isozymes I and II and transmembrane isozymes IX, XII (cancer-associa... Eur J Med Chem. 2010 Jun;45(6):2396-404. DMPNXFA RU https://pubmed.ncbi.nlm.nih.gov/20202722 DMPNXFA DI DMPNXFA DMPNXFA DN 4-(Quinolinoxy)-3-pyridinesulfonamide DMPNXFA MI TTEYTKG DMPNXFA MN Carbonic anhydrase XIV (CA-XIV) DMPNXFA MT DTT DMPNXFA MA Inhibitor DMPNXFA RN Carbonic anhydrase inhibitors: synthesis and inhibition of the human cytosolic isozymes I and II and transmembrane isozymes IX, XII (cancer-associa... Eur J Med Chem. 2010 Jun;45(6):2396-404. DMPNXFA RU https://pubmed.ncbi.nlm.nih.gov/20202722 DM0XDG6 DI DM0XDG6 DM0XDG6 DN 4-(Spiro[chromene-2,4'-piperidine]-4-yl)benzamide DM0XDG6 MI TTVG215 DM0XDG6 MN Debrisoquine 4-hydroxylase (CYP2D6) DM0XDG6 MT DTT DM0XDG6 MA Inhibitor DM0XDG6 RN Spirocyclic delta opioid receptor agonists for the treatment of pain: discovery of N,N-diethyl-3-hydroxy-4-(spiro[chromene-2,4'-piperidine]-4-yl) b... J Med Chem. 2009 Sep 24;52(18):5685-702. DM0XDG6 RU https://pubmed.ncbi.nlm.nih.gov/19694468 DM0XDG6 DI DM0XDG6 DM0XDG6 DN 4-(Spiro[chromene-2,4'-piperidine]-4-yl)benzamide DM0XDG6 MI TT27RFC DM0XDG6 MN Opioid receptor delta (OPRD1) DM0XDG6 MT DTT DM0XDG6 MA Inhibitor DM0XDG6 RN Spirocyclic delta opioid receptor agonists for the treatment of pain: discovery of N,N-diethyl-3-hydroxy-4-(spiro[chromene-2,4'-piperidine]-4-yl) b... J Med Chem. 2009 Sep 24;52(18):5685-702. DM0XDG6 RU https://pubmed.ncbi.nlm.nih.gov/19694468 DM0XDG6 DI DM0XDG6 DM0XDG6 DN 4-(Spiro[chromene-2,4'-piperidine]-4-yl)benzamide DM0XDG6 MI TTQW87Y DM0XDG6 MN Opioid receptor kappa (OPRK1) DM0XDG6 MT DTT DM0XDG6 MA Inhibitor DM0XDG6 RN Spirocyclic delta opioid receptor agonists for the treatment of pain: discovery of N,N-diethyl-3-hydroxy-4-(spiro[chromene-2,4'-piperidine]-4-yl) b... J Med Chem. 2009 Sep 24;52(18):5685-702. DM0XDG6 RU https://pubmed.ncbi.nlm.nih.gov/19694468 DM0XDG6 DI DM0XDG6 DM0XDG6 DN 4-(Spiro[chromene-2,4'-piperidine]-4-yl)benzamide DM0XDG6 MI TTKWM86 DM0XDG6 MN Opioid receptor mu (MOP) DM0XDG6 MT DTT DM0XDG6 MA Inhibitor DM0XDG6 RN Spirocyclic delta opioid receptor agonists for the treatment of pain: discovery of N,N-diethyl-3-hydroxy-4-(spiro[chromene-2,4'-piperidine]-4-yl) b... J Med Chem. 2009 Sep 24;52(18):5685-702. DM0XDG6 RU https://pubmed.ncbi.nlm.nih.gov/19694468 DM0XDG6 DI DM0XDG6 DM0XDG6 DN 4-(Spiro[chromene-2,4'-piperidine]-4-yl)benzamide DM0XDG6 MI TTQ6VDM DM0XDG6 MN Voltage-gated potassium channel Kv11.1 (KCNH2) DM0XDG6 MT DTT DM0XDG6 MA Inhibitor DM0XDG6 RN Spirocyclic delta opioid receptor agonists for the treatment of pain: discovery of N,N-diethyl-3-hydroxy-4-(spiro[chromene-2,4'-piperidine]-4-yl) b... J Med Chem. 2009 Sep 24;52(18):5685-702. DM0XDG6 RU https://pubmed.ncbi.nlm.nih.gov/19694468 DM8ZRAE DI DM8ZRAE DM8ZRAE DN 4-(Spiro[chromene-2,4'-piperidine]-4-yl)phenol DM8ZRAE MI TT27RFC DM8ZRAE MN Opioid receptor delta (OPRD1) DM8ZRAE MT DTT DM8ZRAE MA Inhibitor DM8ZRAE RN Potent, orally bioavailable delta opioid receptor agonists for the treatment of pain: discovery of N,N-diethyl-4-(5-hydroxyspiro[chromene-2,4'-pipe... J Med Chem. 2008 Oct 9;51(19):5893-6. DM8ZRAE RU https://pubmed.ncbi.nlm.nih.gov/18788723 DM8ZRAE DI DM8ZRAE DM8ZRAE DN 4-(Spiro[chromene-2,4'-piperidine]-4-yl)phenol DM8ZRAE MI TTQW87Y DM8ZRAE MN Opioid receptor kappa (OPRK1) DM8ZRAE MT DTT DM8ZRAE MA Inhibitor DM8ZRAE RN Potent, orally bioavailable delta opioid receptor agonists for the treatment of pain: discovery of N,N-diethyl-4-(5-hydroxyspiro[chromene-2,4'-pipe... J Med Chem. 2008 Oct 9;51(19):5893-6. DM8ZRAE RU https://pubmed.ncbi.nlm.nih.gov/18788723 DM8ZRAE DI DM8ZRAE DM8ZRAE DN 4-(Spiro[chromene-2,4'-piperidine]-4-yl)phenol DM8ZRAE MI TTKWM86 DM8ZRAE MN Opioid receptor mu (MOP) DM8ZRAE MT DTT DM8ZRAE MA Inhibitor DM8ZRAE RN Potent, orally bioavailable delta opioid receptor agonists for the treatment of pain: discovery of N,N-diethyl-4-(5-hydroxyspiro[chromene-2,4'-pipe... J Med Chem. 2008 Oct 9;51(19):5893-6. DM8ZRAE RU https://pubmed.ncbi.nlm.nih.gov/18788723 DM8ZRAE DI DM8ZRAE DM8ZRAE DN 4-(Spiro[chromene-2,4'-piperidine]-4-yl)phenol DM8ZRAE MI TTQ6VDM DM8ZRAE MN Voltage-gated potassium channel Kv11.1 (KCNH2) DM8ZRAE MT DTT DM8ZRAE MA Inhibitor DM8ZRAE RN Potent, orally bioavailable delta opioid receptor agonists for the treatment of pain: discovery of N,N-diethyl-4-(5-hydroxyspiro[chromene-2,4'-pipe... J Med Chem. 2008 Oct 9;51(19):5893-6. DM8ZRAE RU https://pubmed.ncbi.nlm.nih.gov/18788723 DMU5A2B DI DMU5A2B DMU5A2B DN 4-(tert-butylamino)naphthalen-1-ol DMU5A2B MI TTZJYKH DMU5A2B MN Indoleamine 2,3-dioxygenase 1 (IDO1) DMU5A2B MT DTT DMU5A2B MA Inhibitor DMU5A2B RN Rational design of indoleamine 2,3-dioxygenase inhibitors. J Med Chem. 2010 Feb 11;53(3):1172-89. DMU5A2B RU https://pubmed.ncbi.nlm.nih.gov/20055453 DMSUM3C DI DMSUM3C DMSUM3C DN 4-(thiazol-2-yl)phenyl butylcarbamate DMSUM3C MI TTDP1UC DMSUM3C MN Fatty acid amide hydrolase (FAAH) DMSUM3C MT DTT DMSUM3C MA Inhibitor DMSUM3C RN Fatty acid amide hydrolase inhibitors from virtual screening of the endocannabinoid system. J Med Chem. 2006 Jul 27;49(15):4650-6. DMSUM3C RU https://pubmed.ncbi.nlm.nih.gov/16854070 DMK3J8Q DI DMK3J8Q DMK3J8Q DN 4-(thiazol-2-yl)thieno[3,2-d]pyrimidin-2-amine DMK3J8Q MI TTK25J1 DMK3J8Q MN Adenosine A1 receptor (ADORA1) DMK3J8Q MT DTT DMK3J8Q MA Inhibitor DMK3J8Q RN Antagonists of the human adenosine A2A receptor. Part 2: Design and synthesis of 4-arylthieno[3,2-d]pyrimidine derivatives. Bioorg Med Chem Lett. 2008 May 1;18(9):2920-3. DMK3J8Q RU https://pubmed.ncbi.nlm.nih.gov/18407496 DMK3J8Q DI DMK3J8Q DMK3J8Q DN 4-(thiazol-2-yl)thieno[3,2-d]pyrimidin-2-amine DMK3J8Q MI TTM2AOE DMK3J8Q MN Adenosine A2a receptor (ADORA2A) DMK3J8Q MT DTT DMK3J8Q MA Inhibitor DMK3J8Q RN Antagonists of the human adenosine A2A receptor. Part 2: Design and synthesis of 4-arylthieno[3,2-d]pyrimidine derivatives. Bioorg Med Chem Lett. 2008 May 1;18(9):2920-3. DMK3J8Q RU https://pubmed.ncbi.nlm.nih.gov/18407496 DMMWZLC DI DMMWZLC DMMWZLC DN 4'-(trifluoromethyl)-4-biphenylol DMMWZLC MI TTBGTCW DMMWZLC MN Kinesin spindle messenger RNA (KIF11 mRNA) DMMWZLC MT DTT DMMWZLC MA Inhibitor DMMWZLC RN Novel ATP-competitive kinesin spindle protein inhibitors. J Med Chem. 2007 Oct 4;50(20):4939-52. DMMWZLC RU https://pubmed.ncbi.nlm.nih.gov/17725339 DMLP67R DI DMLP67R DMLP67R DN 4'-(trifluoromethyl)-4-biphenylsulfonamide DMLP67R MI TTBGTCW DMLP67R MN Kinesin spindle messenger RNA (KIF11 mRNA) DMLP67R MT DTT DMLP67R MA Inhibitor DMLP67R RN Novel ATP-competitive kinesin spindle protein inhibitors. J Med Chem. 2007 Oct 4;50(20):4939-52. DMLP67R RU https://pubmed.ncbi.nlm.nih.gov/17725339 DMT3BX9 DI DMT3BX9 DMT3BX9 DN 4'-(trifluoromethyl)-4-biphenylyl carbamate DMT3BX9 MI TTBGTCW DMT3BX9 MN Kinesin spindle messenger RNA (KIF11 mRNA) DMT3BX9 MT DTT DMT3BX9 MA Inhibitor DMT3BX9 RN Novel ATP-competitive kinesin spindle protein inhibitors. J Med Chem. 2007 Oct 4;50(20):4939-52. DMT3BX9 RU https://pubmed.ncbi.nlm.nih.gov/17725339 DM8PTNR DI DM8PTNR DM8PTNR DN 4'-(trifluoromethyl)-4-biphenylyl sulfamate DM8PTNR MI TTBGTCW DM8PTNR MN Kinesin spindle messenger RNA (KIF11 mRNA) DM8PTNR MT DTT DM8PTNR MA Inhibitor DM8PTNR RN Novel ATP-competitive kinesin spindle protein inhibitors. J Med Chem. 2007 Oct 4;50(20):4939-52. DM8PTNR RU https://pubmed.ncbi.nlm.nih.gov/17725339 DMZ0AKP DI DMZ0AKP DMZ0AKP DN 4-(trifluoromethyl)biphenyl DMZ0AKP MI TTBGTCW DMZ0AKP MN Kinesin spindle messenger RNA (KIF11 mRNA) DMZ0AKP MT DTT DMZ0AKP MA Inhibitor DMZ0AKP RN Novel ATP-competitive kinesin spindle protein inhibitors. J Med Chem. 2007 Oct 4;50(20):4939-52. DMZ0AKP RU https://pubmed.ncbi.nlm.nih.gov/17725339 DMADZQ9 DI DMADZQ9 DMADZQ9 DN 4-(trifluoromethyl)phenylboronic acid DMADZQ9 MI TTDP1UC DMADZQ9 MN Fatty acid amide hydrolase (FAAH) DMADZQ9 MT DTT DMADZQ9 MA Inhibitor DMADZQ9 RN Discovery of boronic acids as novel and potent inhibitors of fatty acid amide hydrolase. J Med Chem. 2008 Nov 27;51(22):7057-60. DMADZQ9 RU https://pubmed.ncbi.nlm.nih.gov/18983140 DM2YAUX DI DM2YAUX DM2YAUX DN 4(Z)-(5'-Deoxyadenosin-5'-ylidene)butanoic acid DM2YAUX MI TTE2KUJ DM2YAUX MN Adenosylhomocysteinase (AHCY) DM2YAUX MT DTT DM2YAUX MA Inhibitor DM2YAUX RN Synthesis of 5'-functionalized nucleosides: S-Adenosylhomocysteine analogues with the carbon-5' and sulfur atoms replaced by a vinyl or halovinyl u... Bioorg Med Chem. 2008 May 15;16(10):5424-33. DM2YAUX RU https://pubmed.ncbi.nlm.nih.gov/18457953 DMB5RJK DI DMB5RJK DMB5RJK DN 4,10-dimethyl-6H-benzo[c]chromene-3,8-diol DMB5RJK MI TTZAYWL DMB5RJK MN Estrogen receptor (ESR) DMB5RJK MT DTT DMB5RJK MA Inhibitor DMB5RJK RN 6H-Benzo[c]chromen-6-one derivatives as selective ERbeta agonists. Bioorg Med Chem Lett. 2006 Mar 15;16(6):1468-72. DMB5RJK RU https://pubmed.ncbi.nlm.nih.gov/16412638 DMB5RJK DI DMB5RJK DMB5RJK DN 4,10-dimethyl-6H-benzo[c]chromene-3,8-diol DMB5RJK MI TTOM3J0 DMB5RJK MN Estrogen receptor beta (ESR2) DMB5RJK MT DTT DMB5RJK MA Inhibitor DMB5RJK RN 6H-Benzo[c]chromen-6-one derivatives as selective ERbeta agonists. Bioorg Med Chem Lett. 2006 Mar 15;16(6):1468-72. DMB5RJK RU https://pubmed.ncbi.nlm.nih.gov/16412638 DM1XTJC DI DM1XTJC DM1XTJC DN 4,12,17-dehydroxyriccardin C DM1XTJC MI TTECBXN DM1XTJC MN Oxysterols receptor LXR-alpha (NR1H3) DM1XTJC MT DTT DM1XTJC MA Inhibitor DM1XTJC RN Co-existence of alpha-glucosidase-inhibitory and liver X receptor-regulatory activities and their separation by structural development. Bioorg Med Chem. 2008 Apr 15;16(8):4272-85. DM1XTJC RU https://pubmed.ncbi.nlm.nih.gov/18343126 DMIZ0GO DI DMIZ0GO DMIZ0GO DN 4,17-dehydroxyriccardin C DMIZ0GO MI TTECBXN DMIZ0GO MN Oxysterols receptor LXR-alpha (NR1H3) DMIZ0GO MT DTT DMIZ0GO MA Inhibitor DMIZ0GO RN Co-existence of alpha-glucosidase-inhibitory and liver X receptor-regulatory activities and their separation by structural development. Bioorg Med Chem. 2008 Apr 15;16(8):4272-85. DMIZ0GO RU https://pubmed.ncbi.nlm.nih.gov/18343126 DMIZ0GO DI DMIZ0GO DMIZ0GO DN 4,17-dehydroxyriccardin C DMIZ0GO MI TTXA6PH DMIZ0GO MN Oxysterols receptor LXR-beta (NR1H2) DMIZ0GO MT DTT DMIZ0GO MA Inhibitor DMIZ0GO RN Co-existence of alpha-glucosidase-inhibitory and liver X receptor-regulatory activities and their separation by structural development. Bioorg Med Chem. 2008 Apr 15;16(8):4272-85. DMIZ0GO RU https://pubmed.ncbi.nlm.nih.gov/18343126 DMBN4G6 DI DMBN4G6 DMBN4G6 DN 4,3'',5''-trimethoxy-[1,1':2',1'']-terphenyl DMBN4G6 MI TTS7G69 DMBN4G6 MN Fusion protein Bcr-Abl (Bcr-Abl) DMBN4G6 MT DTT DMBN4G6 MA Inhibitor DMBN4G6 RN Identification of a terphenyl derivative that blocks the cell cycle in the G0-G1 phase and induces differentiation in leukemia cells. J Med Chem. 2006 May 18;49(10):3012-8. DMBN4G6 RU https://pubmed.ncbi.nlm.nih.gov/16686543 DMBN4G6 DI DMBN4G6 DMBN4G6 DN 4,3'',5''-trimethoxy-[1,1':2',1'']-terphenyl DMBN4G6 MI TT3OT40 DMBN4G6 MN Multidrug resistance protein 1 (ABCB1) DMBN4G6 MT DTT DMBN4G6 MA Inhibitor DMBN4G6 RN Identification of a terphenyl derivative that blocks the cell cycle in the G0-G1 phase and induces differentiation in leukemia cells. J Med Chem. 2006 May 18;49(10):3012-8. DMBN4G6 RU https://pubmed.ncbi.nlm.nih.gov/16686543 DM40E1T DI DM40E1T DM40E1T DN 4,3'',5''-trimethoxy-[1,1':3',1'']-terphenyl DM40E1T MI TTS7G69 DM40E1T MN Fusion protein Bcr-Abl (Bcr-Abl) DM40E1T MT DTT DM40E1T MA Inhibitor DM40E1T RN Identification of a terphenyl derivative that blocks the cell cycle in the G0-G1 phase and induces differentiation in leukemia cells. J Med Chem. 2006 May 18;49(10):3012-8. DM40E1T RU https://pubmed.ncbi.nlm.nih.gov/16686543 DMJKWFI DI DMJKWFI DMJKWFI DN 4,4'-(4-phenylpyridine-2,6-diyl)diphenol DMJKWFI MI TT0IHXV DMJKWFI MN DNA topoisomerase II (TOP2) DMJKWFI MT DTT DMJKWFI MA Inhibitor DMJKWFI RN Synthesis, topoisomerase I and II inhibitory activity, cytotoxicity, and structure-activity relationship study of hydroxylated 2,4-diphenyl-6-aryl ... Bioorg Med Chem. 2010 May 1;18(9):3066-77. DMJKWFI RU https://pubmed.ncbi.nlm.nih.gov/20392646 DM1NVEI DI DM1NVEI DM1NVEI DN 4,4'-(ethane-1,2-diyl)dibenzene-1,3-diol DM1NVEI MI TTULVH8 DM1NVEI MN Tyrosinase (TYR) DM1NVEI MT DTT DM1NVEI MA Inhibitor DM1NVEI RN Molecular design of potent tyrosinase inhibitors having the bibenzyl skeleton. Bioorg Med Chem Lett. 2008 Oct 1;18(19):5252-4. DM1NVEI RU https://pubmed.ncbi.nlm.nih.gov/18782667 DMFGQ02 DI DMFGQ02 DMFGQ02 DN 4,4'-Biphenyldiboronic Acid DMFGQ02 MI TTHI19T DMFGQ02 MN Staphylococcus Beta-lactamase (Stap-coc blaZ) DMFGQ02 MT DTT DMFGQ02 MA Inhibitor DMFGQ02 RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMFGQ02 RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMFPO16 DI DMFPO16 DMFPO16 DN 4',4-Dihydroxychalcone DMFPO16 MI TTULVH8 DMFPO16 MN Tyrosinase (TYR) DMFPO16 MT DTT DMFPO16 MA Inhibitor DMFPO16 RN Evaluation of anti-pigmentary effect of synthetic sulfonylamino chalcone. Eur J Med Chem. 2010 May;45(5):2010-7. DMFPO16 RU https://pubmed.ncbi.nlm.nih.gov/20149498 DM1ONBT DI DM1ONBT DM1ONBT DN 4,4'-dihydroxyoctafluoroazobenzene DM1ONBT MI TTTU72V DM1ONBT MN Steroid 5-alpha-reductase 1 (SRD5A1) DM1ONBT MT DTT DM1ONBT MA Inhibitor DM1ONBT RN Hydroxyperfluoroazobenzenes: novel inhibitors of enzymes of androgen biosynthesis. J Med Chem. 1990 Sep;33(9):2452-5. DM1ONBT RU https://pubmed.ncbi.nlm.nih.gov/2391687 DM1ONBT DI DM1ONBT DM1ONBT DN 4,4'-dihydroxyoctafluoroazobenzene DM1ONBT MI TTT02K8 DM1ONBT MN Steroid 5-alpha-reductase 2 (SRD5A2) DM1ONBT MT DTT DM1ONBT MA Inhibitor DM1ONBT RN Hydroxyperfluoroazobenzenes: novel inhibitors of enzymes of androgen biosynthesis. J Med Chem. 1990 Sep;33(9):2452-5. DM1ONBT RU https://pubmed.ncbi.nlm.nih.gov/2391687 DMQ0TBX DI DMQ0TBX DMQ0TBX DN 4,4-Diphenylbutan-1-amine DMQ0TBX MI TTJQOD7 DMQ0TBX MN 5-HT 2A receptor (HTR2A) DMQ0TBX MT DTT DMQ0TBX MA Inhibitor DMQ0TBX RN Synthesis, structure-affinity relationships, and modeling of AMDA analogs at 5-HT2A and H1 receptors: structural factors contributing to selectivity. Bioorg Med Chem. 2009 Sep 15;17(18):6496-504. DMQ0TBX RU https://pubmed.ncbi.nlm.nih.gov/19700330 DMQ0TBX DI DMQ0TBX DMQ0TBX DN 4,4-Diphenylbutan-1-amine DMQ0TBX MI TTTIBOJ DMQ0TBX MN Histamine H1 receptor (H1R) DMQ0TBX MT DTT DMQ0TBX MA Inhibitor DMQ0TBX RN Synthesis, structure-affinity relationships, and modeling of AMDA analogs at 5-HT2A and H1 receptors: structural factors contributing to selectivity. Bioorg Med Chem. 2009 Sep 15;17(18):6496-504. DMQ0TBX RU https://pubmed.ncbi.nlm.nih.gov/19700330 DMM0H9Y DI DMM0H9Y DMM0H9Y DN 4,4-Diphenyl-N-(pyridin-3-yl)-butyramide DMM0H9Y MI TT7WVHI DMM0H9Y MN Soluble epoxide hydrolase (EPHX2) DMM0H9Y MT DTT DMM0H9Y MA Inhibitor DMM0H9Y RN Structure-based optimization of arylamides as inhibitors of soluble epoxide hydrolase. J Med Chem. 2009 Oct 8;52(19):5880-95. DMM0H9Y RU https://pubmed.ncbi.nlm.nih.gov/19746975 DM0K5JM DI DM0K5JM DM0K5JM DN 4,4'-thiodipyridine-3-sulfonamide DM0K5JM MI TTHQPL7 DM0K5JM MN Carbonic anhydrase I (CA-I) DM0K5JM MT DTT DM0K5JM MA Inhibitor DM0K5JM RN Carbonic anhydrase inhibitors: synthesis and inhibition of the human cytosolic isozymes I and II and transmembrane isozymes IX, XII (cancer-associa... Eur J Med Chem. 2010 Jun;45(6):2396-404. DM0K5JM RU https://pubmed.ncbi.nlm.nih.gov/20202722 DM0K5JM DI DM0K5JM DM0K5JM DN 4,4'-thiodipyridine-3-sulfonamide DM0K5JM MI TTANPDJ DM0K5JM MN Carbonic anhydrase II (CA-II) DM0K5JM MT DTT DM0K5JM MA Inhibitor DM0K5JM RN Carbonic anhydrase inhibitors: synthesis and inhibition of the human cytosolic isozymes I and II and transmembrane isozymes IX, XII (cancer-associa... Eur J Med Chem. 2010 Jun;45(6):2396-404. DM0K5JM RU https://pubmed.ncbi.nlm.nih.gov/20202722 DM0K5JM DI DM0K5JM DM0K5JM DN 4,4'-thiodipyridine-3-sulfonamide DM0K5JM MI TT2LVK8 DM0K5JM MN Carbonic anhydrase IX (CA-IX) DM0K5JM MT DTT DM0K5JM MA Inhibitor DM0K5JM RN Carbonic anhydrase inhibitors: synthesis and inhibition of the human cytosolic isozymes I and II and transmembrane isozymes IX, XII (cancer-associa... Eur J Med Chem. 2010 Jun;45(6):2396-404. DM0K5JM RU https://pubmed.ncbi.nlm.nih.gov/20202722 DM0K5JM DI DM0K5JM DM0K5JM DN 4,4'-thiodipyridine-3-sulfonamide DM0K5JM MI TTSYM0R DM0K5JM MN Carbonic anhydrase XII (CA-XII) DM0K5JM MT DTT DM0K5JM MA Inhibitor DM0K5JM RN Carbonic anhydrase inhibitors: synthesis and inhibition of the human cytosolic isozymes I and II and transmembrane isozymes IX, XII (cancer-associa... Eur J Med Chem. 2010 Jun;45(6):2396-404. DM0K5JM RU https://pubmed.ncbi.nlm.nih.gov/20202722 DM0K5JM DI DM0K5JM DM0K5JM DN 4,4'-thiodipyridine-3-sulfonamide DM0K5JM MI TTEYTKG DM0K5JM MN Carbonic anhydrase XIV (CA-XIV) DM0K5JM MT DTT DM0K5JM MA Inhibitor DM0K5JM RN Carbonic anhydrase inhibitors: synthesis and inhibition of the human cytosolic isozymes I and II and transmembrane isozymes IX, XII (cancer-associa... Eur J Med Chem. 2010 Jun;45(6):2396-404. DM0K5JM RU https://pubmed.ncbi.nlm.nih.gov/20202722 DMUE4K3 DI DMUE4K3 DMUE4K3 DN 4,5,6,7-tetrabromo-1H-benzimidazole DMUE4K3 MI TTER6YH DMUE4K3 MN Casein kinase II alpha (CSNK2A1) DMUE4K3 MT DTT DMUE4K3 MA Inhibitor DMUE4K3 RN Synthesis of new analogs of benzotriazole, benzimidazole and phthalimide--potential inhibitors of human protein kinase CK2. Bioorg Med Chem. 2009 Feb 15;17(4):1573-8. DMUE4K3 RU https://pubmed.ncbi.nlm.nih.gov/19168362 DMN9YOB DI DMN9YOB DMN9YOB DN 4,5,6,7-tetrabromo-1H-benzo[d][1,2,3]triazole DMN9YOB MI TTLAFZV DMN9YOB MN AMP-activated protein kinase (AMPK) DMN9YOB MT DTT DMN9YOB MA Inhibitor DMN9YOB RN Optimization of protein kinase CK2 inhibitors derived from 4,5,6,7-tetrabromobenzimidazole. J Med Chem. 2004 Dec 2;47(25):6239-47. DMN9YOB RU https://pubmed.ncbi.nlm.nih.gov/15566294 DMN9YOB DI DMN9YOB DMN9YOB DN 4,5,6,7-tetrabromo-1H-benzo[d][1,2,3]triazole DMN9YOB MI TTER6YH DMN9YOB MN Casein kinase II alpha (CSNK2A1) DMN9YOB MT DTT DMN9YOB MA Inhibitor DMN9YOB RN Structural insight into human CK2alpha in complex with the potent inhibitor ellagic acid. Bioorg Med Chem Lett. 2009 Jun 1;19(11):2920-3. DMN9YOB RU https://pubmed.ncbi.nlm.nih.gov/19414254 DMN9YOB DI DMN9YOB DMN9YOB DN 4,5,6,7-tetrabromo-1H-benzo[d][1,2,3]triazole DMN9YOB MI TTTU902 DMN9YOB MN Checkpoint kinase-1 (CHK1) DMN9YOB MT DTT DMN9YOB MA Inhibitor DMN9YOB RN Optimization of protein kinase CK2 inhibitors derived from 4,5,6,7-tetrabromobenzimidazole. J Med Chem. 2004 Dec 2;47(25):6239-47. DMN9YOB RU https://pubmed.ncbi.nlm.nih.gov/15566294 DMN9YOB DI DMN9YOB DMN9YOB DN 4,5,6,7-tetrabromo-1H-benzo[d][1,2,3]triazole DMN9YOB MI TTIDAPM DMN9YOB MN ERK activator kinase 1 (MEK1) DMN9YOB MT DTT DMN9YOB MA Inhibitor DMN9YOB RN Optimization of protein kinase CK2 inhibitors derived from 4,5,6,7-tetrabromobenzimidazole. J Med Chem. 2004 Dec 2;47(25):6239-47. DMN9YOB RU https://pubmed.ncbi.nlm.nih.gov/15566294 DMN9YOB DI DMN9YOB DMN9YOB DN 4,5,6,7-tetrabromo-1H-benzo[d][1,2,3]triazole DMN9YOB MI TT4TQBX DMN9YOB MN Extracellular signal-regulated kinase 2 (ERK2) DMN9YOB MT DTT DMN9YOB MA Inhibitor DMN9YOB RN Optimization of protein kinase CK2 inhibitors derived from 4,5,6,7-tetrabromobenzimidazole. J Med Chem. 2004 Dec 2;47(25):6239-47. DMN9YOB RU https://pubmed.ncbi.nlm.nih.gov/15566294 DMN9YOB DI DMN9YOB DMN9YOB DN 4,5,6,7-tetrabromo-1H-benzo[d][1,2,3]triazole DMN9YOB MI TTRSMW9 DMN9YOB MN Glycogen synthase kinase-3 beta (GSK-3B) DMN9YOB MT DTT DMN9YOB MA Inhibitor DMN9YOB RN Optimization of protein kinase CK2 inhibitors derived from 4,5,6,7-tetrabromobenzimidazole. J Med Chem. 2004 Dec 2;47(25):6239-47. DMN9YOB RU https://pubmed.ncbi.nlm.nih.gov/15566294 DMN9YOB DI DMN9YOB DMN9YOB DN 4,5,6,7-tetrabromo-1H-benzo[d][1,2,3]triazole DMN9YOB MI TT860QF DMN9YOB MN LCK tyrosine protein kinase (LCK) DMN9YOB MT DTT DMN9YOB MA Inhibitor DMN9YOB RN Optimization of protein kinase CK2 inhibitors derived from 4,5,6,7-tetrabromobenzimidazole. J Med Chem. 2004 Dec 2;47(25):6239-47. DMN9YOB RU https://pubmed.ncbi.nlm.nih.gov/15566294 DMN9YOB DI DMN9YOB DMN9YOB DN 4,5,6,7-tetrabromo-1H-benzo[d][1,2,3]triazole DMN9YOB MI TTYT93M DMN9YOB MN MAP kinase p38 (MAPK12) DMN9YOB MT DTT DMN9YOB MA Inhibitor DMN9YOB RN Optimization of protein kinase CK2 inhibitors derived from 4,5,6,7-tetrabromobenzimidazole. J Med Chem. 2004 Dec 2;47(25):6239-47. DMN9YOB RU https://pubmed.ncbi.nlm.nih.gov/15566294 DMN9YOB DI DMN9YOB DMN9YOB DN 4,5,6,7-tetrabromo-1H-benzo[d][1,2,3]triazole DMN9YOB MI TTFJ8Q1 DMN9YOB MN Protein kinase C alpha (PRKCA) DMN9YOB MT DTT DMN9YOB MA Inhibitor DMN9YOB RN Optimization of protein kinase CK2 inhibitors derived from 4,5,6,7-tetrabromobenzimidazole. J Med Chem. 2004 Dec 2;47(25):6239-47. DMN9YOB RU https://pubmed.ncbi.nlm.nih.gov/15566294 DMN9YOB DI DMN9YOB DMN9YOB DN 4,5,6,7-tetrabromo-1H-benzo[d][1,2,3]triazole DMN9YOB MI TTWTSCV DMN9YOB MN RAC-alpha serine/threonine-protein kinase (AKT1) DMN9YOB MT DTT DMN9YOB MA Inhibitor DMN9YOB RN Optimization of protein kinase CK2 inhibitors derived from 4,5,6,7-tetrabromobenzimidazole. J Med Chem. 2004 Dec 2;47(25):6239-47. DMN9YOB RU https://pubmed.ncbi.nlm.nih.gov/15566294 DMN9YOB DI DMN9YOB DMN9YOB DN 4,5,6,7-tetrabromo-1H-benzo[d][1,2,3]triazole DMN9YOB MI TTZN7RP DMN9YOB MN Rho-associated protein kinase 1 (ROCK1) DMN9YOB MT DTT DMN9YOB MA Inhibitor DMN9YOB RN Optimization of protein kinase CK2 inhibitors derived from 4,5,6,7-tetrabromobenzimidazole. J Med Chem. 2004 Dec 2;47(25):6239-47. DMN9YOB RU https://pubmed.ncbi.nlm.nih.gov/15566294 DMN9YOB DI DMN9YOB DMN9YOB DN 4,5,6,7-tetrabromo-1H-benzo[d][1,2,3]triazole DMN9YOB MI TTG0U4H DMN9YOB MN Ribosomal protein S6 kinase beta-1 (S6K1) DMN9YOB MT DTT DMN9YOB MA Inhibitor DMN9YOB RN Optimization of protein kinase CK2 inhibitors derived from 4,5,6,7-tetrabromobenzimidazole. J Med Chem. 2004 Dec 2;47(25):6239-47. DMN9YOB RU https://pubmed.ncbi.nlm.nih.gov/15566294 DMN9YOB DI DMN9YOB DMN9YOB DN 4,5,6,7-tetrabromo-1H-benzo[d][1,2,3]triazole DMN9YOB MI TTTV8EJ DMN9YOB MN Serine/threonine-protein kinase Sgk1 (SGK1) DMN9YOB MT DTT DMN9YOB MA Inhibitor DMN9YOB RN Optimization of protein kinase CK2 inhibitors derived from 4,5,6,7-tetrabromobenzimidazole. J Med Chem. 2004 Dec 2;47(25):6239-47. DMN9YOB RU https://pubmed.ncbi.nlm.nih.gov/15566294 DMN9YOB DI DMN9YOB DMN9YOB DN 4,5,6,7-tetrabromo-1H-benzo[d][1,2,3]triazole DMN9YOB MI TTQBR95 DMN9YOB MN Stress-activated protein kinase 2a (p38 alpha) DMN9YOB MT DTT DMN9YOB MA Inhibitor DMN9YOB RN Optimization of protein kinase CK2 inhibitors derived from 4,5,6,7-tetrabromobenzimidazole. J Med Chem. 2004 Dec 2;47(25):6239-47. DMN9YOB RU https://pubmed.ncbi.nlm.nih.gov/15566294 DMN9YOB DI DMN9YOB DMN9YOB DN 4,5,6,7-tetrabromo-1H-benzo[d][1,2,3]triazole DMN9YOB MI TT73U6C DMN9YOB MN Stress-activated protein kinase 2b (p38 beta) DMN9YOB MT DTT DMN9YOB MA Inhibitor DMN9YOB RN Optimization of protein kinase CK2 inhibitors derived from 4,5,6,7-tetrabromobenzimidazole. J Med Chem. 2004 Dec 2;47(25):6239-47. DMN9YOB RU https://pubmed.ncbi.nlm.nih.gov/15566294 DMN9YOB DI DMN9YOB DMN9YOB DN 4,5,6,7-tetrabromo-1H-benzo[d][1,2,3]triazole DMN9YOB MI TT0K6EO DMN9YOB MN Stress-activated protein kinase JNK1 (JNK1) DMN9YOB MT DTT DMN9YOB MA Inhibitor DMN9YOB RN Optimization of protein kinase CK2 inhibitors derived from 4,5,6,7-tetrabromobenzimidazole. J Med Chem. 2004 Dec 2;47(25):6239-47. DMN9YOB RU https://pubmed.ncbi.nlm.nih.gov/15566294 DMTC7J2 DI DMTC7J2 DMTC7J2 DN 4,5,6,7-tetrafluoro-3-methyl-1H-indazole DMTC7J2 MI TTZUFI5 DMTC7J2 MN Nitric-oxide synthase brain (NOS1) DMTC7J2 MT DTT DMTC7J2 MA Inhibitor DMTC7J2 RN Fluorinated indazoles as novel selective inhibitors of nitric oxide synthase (NOS): synthesis and biological evaluation. Bioorg Med Chem. 2009 Sep 1;17(17):6180-7. DMTC7J2 RU https://pubmed.ncbi.nlm.nih.gov/19679481 DMTC7J2 DI DMTC7J2 DMTC7J2 DN 4,5,6,7-tetrafluoro-3-methyl-1H-indazole DMTC7J2 MI TTF10I9 DMTC7J2 MN Nitric-oxide synthase inducible (NOS2) DMTC7J2 MT DTT DMTC7J2 MA Inhibitor DMTC7J2 RN Fluorinated indazoles as novel selective inhibitors of nitric oxide synthase (NOS): synthesis and biological evaluation. Bioorg Med Chem. 2009 Sep 1;17(17):6180-7. DMTC7J2 RU https://pubmed.ncbi.nlm.nih.gov/19679481 DMZEY31 DI DMZEY31 DMZEY31 DN 4,5,6,7-tetrafluoro-3-perfluorophenyl-1H-indazole DMZEY31 MI TTF10I9 DMZEY31 MN Nitric-oxide synthase inducible (NOS2) DMZEY31 MT DTT DMZEY31 MA Inhibitor DMZEY31 RN Fluorinated indazoles as novel selective inhibitors of nitric oxide synthase (NOS): synthesis and biological evaluation. Bioorg Med Chem. 2009 Sep 1;17(17):6180-7. DMZEY31 RU https://pubmed.ncbi.nlm.nih.gov/19679481 DMDQL24 DI DMDQL24 DMDQL24 DN 4,5,6,7-Tetrahydro-1H-indazole-3-carboxylic acid DMDQL24 MI TTWNV8U DMDQL24 MN Nicotinic acid receptor (HCAR2) DMDQL24 MT DTT DMDQL24 MA Inhibitor DMDQL24 RN Pyrazole derivatives as partial agonists for the nicotinic acid receptor. J Med Chem. 2003 Aug 28;46(18):3945-51. DMDQL24 RU https://pubmed.ncbi.nlm.nih.gov/12930155 DMO91EH DI DMO91EH DMO91EH DN 4,5,6,7-tetrahydroisoxazolo-[5,4-c]-pyridin-3-ol DMO91EH MI TTAN6JD DMO91EH MN Glutamate receptor AMPA (GRIA) DMO91EH MT DTT DMO91EH MA Agonist DMO91EH RN Reduction in potency of selective gamma-aminobutyric acidA agonists and diazepam in CA1 region of in vitro hippocampal slices from chronic flurazepam-treated rats. J Pharmacol Exp Ther. 1992 Jul;262(1):204-11. DMO91EH RU https://pubmed.ncbi.nlm.nih.gov/1320683 DMQFTJ7 DI DMQFTJ7 DMQFTJ7 DN 4,5,6-trihydroxy-3-methylphthalide DMQFTJ7 MI TTWTSCV DMQFTJ7 MN RAC-alpha serine/threonine-protein kinase (AKT1) DMQFTJ7 MT DTT DMQFTJ7 MA Inhibitor DMQFTJ7 RN A phthalide with in vitro growth inhibitory activity from an oidiodendron strain. J Nat Prod. 2004 Dec;67(12):2086-9. DMQFTJ7 RU https://pubmed.ncbi.nlm.nih.gov/15620258 DMXZ9PI DI DMXZ9PI DMXZ9PI DN 4,5,7-Trichloro-3-hydroxy-1H-quinolin-2-one DMXZ9PI MI TTLD29N DMXZ9PI MN Glutamate receptor ionotropic NMDA 1 (NMDAR1) DMXZ9PI MT DTT DMXZ9PI MA Inhibitor DMXZ9PI RN 3-Hydroxy-quinolin-2-ones: Inhibitors of [3H]-glycine binding to the site associated with the NMDA receptor, Bioorg. Med. Chem. Lett. 6(5):499-504 (1996). DMXZ9PI RU http://www.sciencedirect.com/science/article/pii/0960894X96000315 DMXZ9PI DI DMXZ9PI DMXZ9PI DN 4,5,7-Trichloro-3-hydroxy-1H-quinolin-2-one DMXZ9PI MI TTKJEMQ DMXZ9PI MN Glutamate receptor ionotropic NMDA 2A (NMDAR2A) DMXZ9PI MT DTT DMXZ9PI MA Inhibitor DMXZ9PI RN 3-Hydroxy-quinolin-2-ones: Inhibitors of [3H]-glycine binding to the site associated with the NMDA receptor, Bioorg. Med. Chem. Lett. 6(5):499-504 (1996). DMXZ9PI RU http://www.sciencedirect.com/science/article/pii/0960894X96000315 DMXZ9PI DI DMXZ9PI DMXZ9PI DN 4,5,7-Trichloro-3-hydroxy-1H-quinolin-2-one DMXZ9PI MI TTN9D8E DMXZ9PI MN Glutamate receptor ionotropic NMDA 2B (NMDAR2B) DMXZ9PI MT DTT DMXZ9PI MA Inhibitor DMXZ9PI RN 3-Hydroxy-quinolin-2-ones: Inhibitors of [3H]-glycine binding to the site associated with the NMDA receptor, Bioorg. Med. Chem. Lett. 6(5):499-504 (1996). DMXZ9PI RU http://www.sciencedirect.com/science/article/pii/0960894X96000315 DM1RM3H DI DM1RM3H DM1RM3H DN 4',5,7-trihydroxy-6,8-dimethylisoflavone DM1RM3H MI TTZAYWL DM1RM3H MN Estrogen receptor (ESR) DM1RM3H MT DTT DM1RM3H MA Inhibitor DM1RM3H RN Isolation and structure elucidation of an isoflavone and a sesterterpenoic acid from Henriettella fascicularis. J Nat Prod. 2002 Dec;65(12):1749-53. DM1RM3H RU https://pubmed.ncbi.nlm.nih.gov/12502307 DM1RM3H DI DM1RM3H DM1RM3H DN 4',5,7-trihydroxy-6,8-dimethylisoflavone DM1RM3H MI TTOM3J0 DM1RM3H MN Estrogen receptor beta (ESR2) DM1RM3H MT DTT DM1RM3H MA Inhibitor DM1RM3H RN Isolation and structure elucidation of an isoflavone and a sesterterpenoic acid from Henriettella fascicularis. J Nat Prod. 2002 Dec;65(12):1749-53. DM1RM3H RU https://pubmed.ncbi.nlm.nih.gov/12502307 DMIO254 DI DMIO254 DMIO254 DN 4,5-Bis(4-chlorophenyl)-1,2-selenazole DMIO254 MI TT8NGED DMIO254 MN Prostaglandin G/H synthase 1 (COX-1) DMIO254 MT DTT DMIO254 MA Inhibitor DMIO254 RN Investigations concerning the COX/5-LOX inhibiting and hydroxyl radical scavenging potencies of novel 4,5-diaryl isoselenazoles. Eur J Med Chem. 2008 Jun;43(6):1152-9. DMIO254 RU https://pubmed.ncbi.nlm.nih.gov/17976864 DMIO254 DI DMIO254 DMIO254 DN 4,5-Bis(4-chlorophenyl)-1,2-selenazole DMIO254 MI TTVKILB DMIO254 MN Prostaglandin G/H synthase 2 (COX-2) DMIO254 MT DTT DMIO254 MA Inhibitor DMIO254 RN Investigations concerning the COX/5-LOX inhibiting and hydroxyl radical scavenging potencies of novel 4,5-diaryl isoselenazoles. Eur J Med Chem. 2008 Jun;43(6):1152-9. DMIO254 RU https://pubmed.ncbi.nlm.nih.gov/17976864 DMENLFY DI DMENLFY DMENLFY DN 4,5-Bis(4-chlorophenyl)isothiazole DMENLFY MI TT8NGED DMENLFY MN Prostaglandin G/H synthase 1 (COX-1) DMENLFY MT DTT DMENLFY MA Inhibitor DMENLFY RN Diaryl-dithiolanes and -isothiazoles: COX-1/COX-2 and 5-LOX-inhibitory, *OH scavenging and anti-adhesive activities. Bioorg Med Chem. 2009 Jan 15;17(2):558-68. DMENLFY RU https://pubmed.ncbi.nlm.nih.gov/19097798 DMENLFY DI DMENLFY DMENLFY DN 4,5-Bis(4-chlorophenyl)isothiazole DMENLFY MI TTVKILB DMENLFY MN Prostaglandin G/H synthase 2 (COX-2) DMENLFY MT DTT DMENLFY MA Inhibitor DMENLFY RN Diaryl-dithiolanes and -isothiazoles: COX-1/COX-2 and 5-LOX-inhibitory, *OH scavenging and anti-adhesive activities. Bioorg Med Chem. 2009 Jan 15;17(2):558-68. DMENLFY RU https://pubmed.ncbi.nlm.nih.gov/19097798 DMKHD1M DI DMKHD1M DMKHD1M DN 4,5-Bis(4-methoxyphenyl)-1,2-selenazole DMKHD1M MI TT8NGED DMKHD1M MN Prostaglandin G/H synthase 1 (COX-1) DMKHD1M MT DTT DMKHD1M MA Inhibitor DMKHD1M RN Investigations concerning the COX/5-LOX inhibiting and hydroxyl radical scavenging potencies of novel 4,5-diaryl isoselenazoles. Eur J Med Chem. 2008 Jun;43(6):1152-9. DMKHD1M RU https://pubmed.ncbi.nlm.nih.gov/17976864 DMKHD1M DI DMKHD1M DMKHD1M DN 4,5-Bis(4-methoxyphenyl)-1,2-selenazole DMKHD1M MI TTVKILB DMKHD1M MN Prostaglandin G/H synthase 2 (COX-2) DMKHD1M MT DTT DMKHD1M MA Inhibitor DMKHD1M RN Investigations concerning the COX/5-LOX inhibiting and hydroxyl radical scavenging potencies of novel 4,5-diaryl isoselenazoles. Eur J Med Chem. 2008 Jun;43(6):1152-9. DMKHD1M RU https://pubmed.ncbi.nlm.nih.gov/17976864 DMI39QT DI DMI39QT DMI39QT DN 4,5-Bis(4-methoxyphenyl)-3H-1,2-dithiol-3-one DMI39QT MI TT8NGED DMI39QT MN Prostaglandin G/H synthase 1 (COX-1) DMI39QT MT DTT DMI39QT MA Inhibitor DMI39QT RN Diaryl-dithiolanes and -isothiazoles: COX-1/COX-2 and 5-LOX-inhibitory, *OH scavenging and anti-adhesive activities. Bioorg Med Chem. 2009 Jan 15;17(2):558-68. DMI39QT RU https://pubmed.ncbi.nlm.nih.gov/19097798 DMI39QT DI DMI39QT DMI39QT DN 4,5-Bis(4-methoxyphenyl)-3H-1,2-dithiol-3-one DMI39QT MI TTVKILB DMI39QT MN Prostaglandin G/H synthase 2 (COX-2) DMI39QT MT DTT DMI39QT MA Inhibitor DMI39QT RN Diaryl-dithiolanes and -isothiazoles: COX-1/COX-2 and 5-LOX-inhibitory, *OH scavenging and anti-adhesive activities. Bioorg Med Chem. 2009 Jan 15;17(2):558-68. DMI39QT RU https://pubmed.ncbi.nlm.nih.gov/19097798 DMPW145 DI DMPW145 DMPW145 DN 4,5-Bis(4-methoxyphenyl)-3H-1,2-dithiole-3-thione DMPW145 MI TT8NGED DMPW145 MN Prostaglandin G/H synthase 1 (COX-1) DMPW145 MT DTT DMPW145 MA Inhibitor DMPW145 RN Diaryl-dithiolanes and -isothiazoles: COX-1/COX-2 and 5-LOX-inhibitory, *OH scavenging and anti-adhesive activities. Bioorg Med Chem. 2009 Jan 15;17(2):558-68. DMPW145 RU https://pubmed.ncbi.nlm.nih.gov/19097798 DM90DV6 DI DM90DV6 DM90DV6 DN 4,5-Bis(4-methoxyphenyl)isothiazole DM90DV6 MI TT8NGED DM90DV6 MN Prostaglandin G/H synthase 1 (COX-1) DM90DV6 MT DTT DM90DV6 MA Inhibitor DM90DV6 RN Diaryl-dithiolanes and -isothiazoles: COX-1/COX-2 and 5-LOX-inhibitory, *OH scavenging and anti-adhesive activities. Bioorg Med Chem. 2009 Jan 15;17(2):558-68. DM90DV6 RU https://pubmed.ncbi.nlm.nih.gov/19097798 DM90DV6 DI DM90DV6 DM90DV6 DN 4,5-Bis(4-methoxyphenyl)isothiazole DM90DV6 MI TTVKILB DM90DV6 MN Prostaglandin G/H synthase 2 (COX-2) DM90DV6 MT DTT DM90DV6 MA Inhibitor DM90DV6 RN Diaryl-dithiolanes and -isothiazoles: COX-1/COX-2 and 5-LOX-inhibitory, *OH scavenging and anti-adhesive activities. Bioorg Med Chem. 2009 Jan 15;17(2):558-68. DM90DV6 RU https://pubmed.ncbi.nlm.nih.gov/19097798 DMHURXY DI DMHURXY DMHURXY DN 4,5-dibenzylbenzene-1,2-diol DMHURXY MI TTJGNVC DMHURXY MN Apoptosis regulator Bcl-2 (BCL-2) DMHURXY MT DTT DMHURXY MA Inhibitor DMHURXY RN Vaccinia virus virulence factor N1L is a novel promising target for antiviral therapeutic intervention. J Med Chem. 2010 May 27;53(10):3899-906. DMHURXY RU https://pubmed.ncbi.nlm.nih.gov/20441222 DMHURXY DI DMHURXY DMHURXY DN 4,5-dibenzylbenzene-1,2-diol DMHURXY MI TTRE6AX DMHURXY MN Bcl-x messenger RNA (BCL2L1 mRNA) DMHURXY MT DTT DMHURXY MA Inhibitor DMHURXY RN Vaccinia virus virulence factor N1L is a novel promising target for antiviral therapeutic intervention. J Med Chem. 2010 May 27;53(10):3899-906. DMHURXY RU https://pubmed.ncbi.nlm.nih.gov/20441222 DMDM9UV DI DMDM9UV DMDM9UV DN 4,5-Dibromo-1H-pyrrole-2-carboxylic acid amide DMDM9UV MI TTIDAPM DMDM9UV MN ERK activator kinase 1 (MEK1) DMDM9UV MT DTT DMDM9UV MA Inhibitor DMDM9UV RN Aldisine alkaloids from the Philippine sponge Stylissa massa are potent inhibitors of mitogen-activated protein kinase kinase-1 (MEK-1). J Med Chem. 2002 Jan 17;45(2):529-32. DMDM9UV RU https://pubmed.ncbi.nlm.nih.gov/11784156 DMX94EK DI DMX94EK DMX94EK DN 4,5-dichloro-1H-indole-2,3-dione DMX94EK MI TTMF541 DMX94EK MN Liver carboxylesterase (CES1) DMX94EK MT DTT DMX94EK MA Inhibitor DMX94EK RN Selective inhibition of carboxylesterases by isatins, indole-2,3-diones. J Med Chem. 2007 Apr 19;50(8):1876-85. DMX94EK RU https://pubmed.ncbi.nlm.nih.gov/17378546 DMG8KRN DI DMG8KRN DMG8KRN DN 4,5-Dihydroxy-10H-anthracen-9-one DMG8KRN MI TT2J34L DMG8KRN MN Arachidonate 5-lipoxygenase (5-LOX) DMG8KRN MT DTT DMG8KRN MA Inhibitor DMG8KRN RN Simple analogues of anthralin: unusual specificity of structure and antiproliferative activity. J Med Chem. 1997 Nov 7;40(23):3773-80. DMG8KRN RU https://pubmed.ncbi.nlm.nih.gov/9371243 DM34L89 DI DM34L89 DM34L89 DN 4,5-Dimethoxy-10H-anthracen-9-one DM34L89 MI TT2J34L DM34L89 MN Arachidonate 5-lipoxygenase (5-LOX) DM34L89 MT DTT DM34L89 MA Inhibitor DM34L89 RN Simple analogues of anthralin: unusual specificity of structure and antiproliferative activity. J Med Chem. 1997 Nov 7;40(23):3773-80. DM34L89 RU https://pubmed.ncbi.nlm.nih.gov/9371243 DMB9CJM DI DMB9CJM DMB9CJM DN 4,5-Dimethyl-pyrrolidin-(2Z)-ylideneamine DMB9CJM MI TTZUFI5 DMB9CJM MN Nitric-oxide synthase brain (NOS1) DMB9CJM MT DTT DMB9CJM MA Inhibitor DMB9CJM RN Evaluation of pyrrolidin-2-imines and 1,3-thiazolidin-2-imines as inhibitors of nitric oxide synthase. Bioorg Med Chem Lett. 2004 Sep 6;14(17):4539-44. DMB9CJM RU https://pubmed.ncbi.nlm.nih.gov/15357988 DMB9CJM DI DMB9CJM DMB9CJM DN 4,5-Dimethyl-pyrrolidin-(2Z)-ylideneamine DMB9CJM MI TTCM4B3 DMB9CJM MN Nitric-oxide synthase endothelial (NOS3) DMB9CJM MT DTT DMB9CJM MA Inhibitor DMB9CJM RN Evaluation of pyrrolidin-2-imines and 1,3-thiazolidin-2-imines as inhibitors of nitric oxide synthase. Bioorg Med Chem Lett. 2004 Sep 6;14(17):4539-44. DMB9CJM RU https://pubmed.ncbi.nlm.nih.gov/15357988 DMB9CJM DI DMB9CJM DMB9CJM DN 4,5-Dimethyl-pyrrolidin-(2Z)-ylideneamine DMB9CJM MI TTF10I9 DMB9CJM MN Nitric-oxide synthase inducible (NOS2) DMB9CJM MT DTT DMB9CJM MA Inhibitor DMB9CJM RN Evaluation of pyrrolidin-2-imines and 1,3-thiazolidin-2-imines as inhibitors of nitric oxide synthase. Bioorg Med Chem Lett. 2004 Sep 6;14(17):4539-44. DMB9CJM RU https://pubmed.ncbi.nlm.nih.gov/15357988 DMXNP2W DI DMXNP2W DMXNP2W DN 4,5-ISOBUDLEIN A DMXNP2W MI TTSXVID DMXNP2W MN Nuclear factor NF-kappa-B (NFKB) DMXNP2W MT DTT DMXNP2W MA Inhibitor DMXNP2W RN Development of a structural model for NF-kappaB inhibition of sesquiterpene lactones using self-organizing neural networks. J Med Chem. 2006 Apr 6;49(7):2241-52. DMXNP2W RU https://pubmed.ncbi.nlm.nih.gov/16570920 DM6N98E DI DM6N98E DM6N98E DN 4,6,10-trimethyl-6H-benzo[c]chromene-3,8-diol DM6N98E MI TTZAYWL DM6N98E MN Estrogen receptor (ESR) DM6N98E MT DTT DM6N98E MA Inhibitor DM6N98E RN 6H-Benzo[c]chromen-6-one derivatives as selective ERbeta agonists. Bioorg Med Chem Lett. 2006 Mar 15;16(6):1468-72. DM6N98E RU https://pubmed.ncbi.nlm.nih.gov/16412638 DM6N98E DI DM6N98E DM6N98E DN 4,6,10-trimethyl-6H-benzo[c]chromene-3,8-diol DM6N98E MI TTOM3J0 DM6N98E MN Estrogen receptor beta (ESR2) DM6N98E MT DTT DM6N98E MA Inhibitor DM6N98E RN 6H-Benzo[c]chromen-6-one derivatives as selective ERbeta agonists. Bioorg Med Chem Lett. 2006 Mar 15;16(6):1468-72. DM6N98E RU https://pubmed.ncbi.nlm.nih.gov/16412638 DM14VI3 DI DM14VI3 DM14VI3 DN 4,6,6,7-tetramethyl-6H-benzo[c]chromene-3,8-diol DM14VI3 MI TTZAYWL DM14VI3 MN Estrogen receptor (ESR) DM14VI3 MT DTT DM14VI3 MA Inhibitor DM14VI3 RN 6H-Benzo[c]chromen-6-one derivatives as selective ERbeta agonists. Bioorg Med Chem Lett. 2006 Mar 15;16(6):1468-72. DM14VI3 RU https://pubmed.ncbi.nlm.nih.gov/16412638 DM14VI3 DI DM14VI3 DM14VI3 DN 4,6,6,7-tetramethyl-6H-benzo[c]chromene-3,8-diol DM14VI3 MI TTOM3J0 DM14VI3 MN Estrogen receptor beta (ESR2) DM14VI3 MT DTT DM14VI3 MA Inhibitor DM14VI3 RN 6H-Benzo[c]chromen-6-one derivatives as selective ERbeta agonists. Bioorg Med Chem Lett. 2006 Mar 15;16(6):1468-72. DM14VI3 RU https://pubmed.ncbi.nlm.nih.gov/16412638 DMYN25U DI DMYN25U DMYN25U DN 4,6,7,10-tetramethyl-6H-benzo[c]chromene-3,8-diol DMYN25U MI TTZAYWL DMYN25U MN Estrogen receptor (ESR) DMYN25U MT DTT DMYN25U MA Inhibitor DMYN25U RN 6H-Benzo[c]chromen-6-one derivatives as selective ERbeta agonists. Bioorg Med Chem Lett. 2006 Mar 15;16(6):1468-72. DMYN25U RU https://pubmed.ncbi.nlm.nih.gov/16412638 DMYN25U DI DMYN25U DMYN25U DN 4,6,7,10-tetramethyl-6H-benzo[c]chromene-3,8-diol DMYN25U MI TTOM3J0 DMYN25U MN Estrogen receptor beta (ESR2) DMYN25U MT DTT DMYN25U MA Inhibitor DMYN25U RN 6H-Benzo[c]chromen-6-one derivatives as selective ERbeta agonists. Bioorg Med Chem Lett. 2006 Mar 15;16(6):1468-72. DMYN25U RU https://pubmed.ncbi.nlm.nih.gov/16412638 DMFECXI DI DMFECXI DMFECXI DN 4,6,7-trimethyl-6H-benzo[c]chromene-3,8-diol DMFECXI MI TTZAYWL DMFECXI MN Estrogen receptor (ESR) DMFECXI MT DTT DMFECXI MA Inhibitor DMFECXI RN 6H-Benzo[c]chromen-6-one derivatives as selective ERbeta agonists. Bioorg Med Chem Lett. 2006 Mar 15;16(6):1468-72. DMFECXI RU https://pubmed.ncbi.nlm.nih.gov/16412638 DMFECXI DI DMFECXI DMFECXI DN 4,6,7-trimethyl-6H-benzo[c]chromene-3,8-diol DMFECXI MI TTOM3J0 DMFECXI MN Estrogen receptor beta (ESR2) DMFECXI MT DTT DMFECXI MA Inhibitor DMFECXI RN 6H-Benzo[c]chromen-6-one derivatives as selective ERbeta agonists. Bioorg Med Chem Lett. 2006 Mar 15;16(6):1468-72. DMFECXI RU https://pubmed.ncbi.nlm.nih.gov/16412638 DMHBO17 DI DMHBO17 DMHBO17 DN 4,6-dichloro-1H-indole-2,3-dione DMHBO17 MI TTMF541 DMHBO17 MN Liver carboxylesterase (CES1) DMHBO17 MT DTT DMHBO17 MA Inhibitor DMHBO17 RN Selective inhibition of carboxylesterases by isatins, indole-2,3-diones. J Med Chem. 2007 Apr 19;50(8):1876-85. DMHBO17 RU https://pubmed.ncbi.nlm.nih.gov/17378546 DM62XC3 DI DM62XC3 DM62XC3 DN 4,6-Dichloro-1H-indole-2-carboxylic acid DM62XC3 MI TTWHDVK DM62XC3 MN Fructose-1,6-bisphosphatase (FBP) DM62XC3 MT DTT DM62XC3 MA Inhibitor DM62XC3 RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DM62XC3 RU https://pubmed.ncbi.nlm.nih.gov/10592235 DM62XC3 DI DM62XC3 DM62XC3 DN 4,6-Dichloro-1H-indole-2-carboxylic acid DM62XC3 MI TTLD29N DM62XC3 MN Glutamate receptor ionotropic NMDA 1 (NMDAR1) DM62XC3 MT DTT DM62XC3 MA Inhibitor DM62XC3 RN 3-(2-carboxyindol-3-yl)propionic acid derivatives: antagonists of the strychnine-insensitive glycine receptor associated with the N-methyl-D-aspart... J Med Chem. 1990 Nov;33(11):2944-6. DM62XC3 RU https://pubmed.ncbi.nlm.nih.gov/2146391 DM62XC3 DI DM62XC3 DM62XC3 DN 4,6-Dichloro-1H-indole-2-carboxylic acid DM62XC3 MI TTKJEMQ DM62XC3 MN Glutamate receptor ionotropic NMDA 2A (NMDAR2A) DM62XC3 MT DTT DM62XC3 MA Inhibitor DM62XC3 RN 3-(2-carboxyindol-3-yl)propionic acid derivatives: antagonists of the strychnine-insensitive glycine receptor associated with the N-methyl-D-aspart... J Med Chem. 1990 Nov;33(11):2944-6. DM62XC3 RU https://pubmed.ncbi.nlm.nih.gov/2146391 DM62XC3 DI DM62XC3 DM62XC3 DN 4,6-Dichloro-1H-indole-2-carboxylic acid DM62XC3 MI TTN9D8E DM62XC3 MN Glutamate receptor ionotropic NMDA 2B (NMDAR2B) DM62XC3 MT DTT DM62XC3 MA Inhibitor DM62XC3 RN 3-(2-carboxyindol-3-yl)propionic acid derivatives: antagonists of the strychnine-insensitive glycine receptor associated with the N-methyl-D-aspart... J Med Chem. 1990 Nov;33(11):2944-6. DM62XC3 RU https://pubmed.ncbi.nlm.nih.gov/2146391 DMBZIG7 DI DMBZIG7 DMBZIG7 DN 4,6-Dideoxy-4-Amino-Alpha-D-Glucose DMBZIG7 MI TTCGSZ4 DMBZIG7 MN Pancreatic alpha-amylase (AMY2A) DMBZIG7 MT DTT DMBZIG7 MA Inhibitor DMBZIG7 RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMBZIG7 RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMP5M9E DI DMP5M9E DMP5M9E DN 4,6-Dideoxyglucose DMP5M9E MI TTHCF4J DMP5M9E MN Alpha-glucosidase (GLA) DMP5M9E MT DTT DMP5M9E MA Inhibitor DMP5M9E RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMP5M9E RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMIJ4VZ DI DMIJ4VZ DMIJ4VZ DN 4,6-Dinitro salicylic acid DMIJ4VZ MI TTHQPL7 DMIJ4VZ MN Carbonic anhydrase I (CA-I) DMIJ4VZ MT DTT DMIJ4VZ MA Inhibitor DMIJ4VZ RN In vitro inhibition of salicylic acid derivatives on human cytosolic carbonic anhydrase isozymes I and II. Bioorg Med Chem. 2008 Oct 15;16(20):9101-5. DMIJ4VZ RU https://pubmed.ncbi.nlm.nih.gov/18819808 DMIJ4VZ DI DMIJ4VZ DMIJ4VZ DN 4,6-Dinitro salicylic acid DMIJ4VZ MI TTANPDJ DMIJ4VZ MN Carbonic anhydrase II (CA-II) DMIJ4VZ MT DTT DMIJ4VZ MA Inhibitor DMIJ4VZ RN In vitro inhibition of salicylic acid derivatives on human cytosolic carbonic anhydrase isozymes I and II. Bioorg Med Chem. 2008 Oct 15;16(20):9101-5. DMIJ4VZ RU https://pubmed.ncbi.nlm.nih.gov/18819808 DMWDYLR DI DMWDYLR DMWDYLR DN 4,6-dinitrobenzo[c][1,2,5]thiadiazole DMWDYLR MI TTR7UJ3 DMWDYLR MN Cytoplasmic thioredoxin reductase (TXNRD1) DMWDYLR MT DTT DMWDYLR MA Inhibitor DMWDYLR RN Specific inhibitors of Plasmodium falciparum thioredoxin reductase as potential antimalarial agents. Bioorg Med Chem Lett. 2006 Apr 15;16(8):2283-92. DMWDYLR RU https://pubmed.ncbi.nlm.nih.gov/16458512 DMEVK5F DI DMEVK5F DMEVK5F DN 4,7-dichloro-1H-indole-2,3-dione DMEVK5F MI TTMF541 DMEVK5F MN Liver carboxylesterase (CES1) DMEVK5F MT DTT DMEVK5F MA Inhibitor DMEVK5F RN Selective inhibition of carboxylesterases by isatins, indole-2,3-diones. J Med Chem. 2007 Apr 19;50(8):1876-85. DMEVK5F RU https://pubmed.ncbi.nlm.nih.gov/17378546 DM67Z81 DI DM67Z81 DM67Z81 DN 4,7-dimethyl-6H-benzo[c]chromene-3,8-diol DM67Z81 MI TTZAYWL DM67Z81 MN Estrogen receptor (ESR) DM67Z81 MT DTT DM67Z81 MA Inhibitor DM67Z81 RN 6H-Benzo[c]chromen-6-one derivatives as selective ERbeta agonists. Bioorg Med Chem Lett. 2006 Mar 15;16(6):1468-72. DM67Z81 RU https://pubmed.ncbi.nlm.nih.gov/16412638 DM67Z81 DI DM67Z81 DM67Z81 DN 4,7-dimethyl-6H-benzo[c]chromene-3,8-diol DM67Z81 MI TTOM3J0 DM67Z81 MN Estrogen receptor beta (ESR2) DM67Z81 MT DTT DM67Z81 MA Inhibitor DM67Z81 RN 6H-Benzo[c]chromen-6-one derivatives as selective ERbeta agonists. Bioorg Med Chem Lett. 2006 Mar 15;16(6):1468-72. DM67Z81 RU https://pubmed.ncbi.nlm.nih.gov/16412638 DML5302 DI DML5302 DML5302 DN 4,7-Dioxosebacic Acid DML5302 MI TTJHKYD DML5302 MN Delta-aminolevulinic acid dehydratase (ALAD) DML5302 MT DTT DML5302 MA Inhibitor DML5302 RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DML5302 RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMQNXL1 DI DMQNXL1 DMQNXL1 DN 4,8-Dimethyl-7-(2'-oxocyclohexyloxy)coumarin DMQNXL1 MI TT3WG5C DMQNXL1 MN Monoamine oxidase type A (MAO-A) DMQNXL1 MT DTT DMQNXL1 MA Inhibitor DMQNXL1 RN Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors. J Med Chem. 2008 Nov 13;51(21):6740-51. DMQNXL1 RU https://pubmed.ncbi.nlm.nih.gov/18834112 DMQNXL1 DI DMQNXL1 DMQNXL1 DN 4,8-Dimethyl-7-(2'-oxocyclohexyloxy)coumarin DMQNXL1 MI TTGP7BY DMQNXL1 MN Monoamine oxidase type B (MAO-B) DMQNXL1 MT DTT DMQNXL1 MA Inhibitor DMQNXL1 RN Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors. J Med Chem. 2008 Nov 13;51(21):6740-51. DMQNXL1 RU https://pubmed.ncbi.nlm.nih.gov/18834112 DMEKI1B DI DMEKI1B DMEKI1B DN 4,9-anhydro-tetrodotoxin DMEKI1B MI TT54ERL DMEKI1B MN Voltage-gated sodium channel alpha Nav1.6 (SCN8A) DMEKI1B MT DTT DMEKI1B MA Blocker (channel blocker) DMEKI1B RN The TTX metabolite 4,9-anhydro-TTX is a highly specific blocker of the Na(v1.6) voltage-dependent sodium channel. Am J Physiol Cell Physiol. 2007 Aug;293(2):C783-9. DMEKI1B RU https://pubmed.ncbi.nlm.nih.gov/17522141 DM27HMT DI DM27HMT DM27HMT DN 4,9-Dihydro-3H-beta-carboline DM27HMT MI TT3WG5C DM27HMT MN Monoamine oxidase type A (MAO-A) DM27HMT MT DTT DM27HMT MA Inhibitor DM27HMT RN Pyrazino[1,2-a]indoles as novel high-affinity and selective imidazoline I(2) receptor ligands. Bioorg Med Chem Lett. 2004 Feb 23;14(4):1003-5. DM27HMT RU https://pubmed.ncbi.nlm.nih.gov/15013010 DM27HMT DI DM27HMT DM27HMT DN 4,9-Dihydro-3H-beta-carboline DM27HMT MI TTGP7BY DM27HMT MN Monoamine oxidase type B (MAO-B) DM27HMT MT DTT DM27HMT MA Inhibitor DM27HMT RN Pyrazino[1,2-a]indoles as novel high-affinity and selective imidazoline I(2) receptor ligands. Bioorg Med Chem Lett. 2004 Feb 23;14(4):1003-5. DM27HMT RU https://pubmed.ncbi.nlm.nih.gov/15013010 DM8BPTQ DI DM8BPTQ DM8BPTQ DN 4-[(2-Methyl-1H-imidazol-1-yl)methyl]pyridine DM8BPTQ MI TTZUFI5 DM8BPTQ MN Nitric-oxide synthase brain (NOS1) DM8BPTQ MT DTT DM8BPTQ MA Inhibitor DM8BPTQ RN N-Substituted acetamidines and 2-methylimidazole derivatives as selective inhibitors of neuronal nitric oxide synthase. Bioorg Med Chem Lett. 2010 Nov 15;20(22):6495-9. DM8BPTQ RU https://pubmed.ncbi.nlm.nih.gov/20933416 DM8BPTQ DI DM8BPTQ DM8BPTQ DN 4-[(2-Methyl-1H-imidazol-1-yl)methyl]pyridine DM8BPTQ MI TTF10I9 DM8BPTQ MN Nitric-oxide synthase inducible (NOS2) DM8BPTQ MT DTT DM8BPTQ MA Inhibitor DM8BPTQ RN N-Substituted acetamidines and 2-methylimidazole derivatives as selective inhibitors of neuronal nitric oxide synthase. Bioorg Med Chem Lett. 2010 Nov 15;20(22):6495-9. DM8BPTQ RU https://pubmed.ncbi.nlm.nih.gov/20933416 DMSKJ1X DI DMSKJ1X DMSKJ1X DN 4-[(3,5-diamino-1H-pyrazol-4-yl)diazenyl]phenol DMSKJ1X MI TTW4Y2M DMSKJ1X MN cAMP protein kinase type II-beta (PRKAR2B) DMSKJ1X MT DTT DMSKJ1X MA Inhibitor DMSKJ1X RN 4-arylazo-3,5-diamino-1H-pyrazole CDK inhibitors: SAR study, crystal structure in complex with CDK2, selectivity, and cellular effects. J Med Chem. 2006 Nov 2;49(22):6500-9. DMSKJ1X RU https://pubmed.ncbi.nlm.nih.gov/17064068 DMSKJ1X DI DMSKJ1X DMSKJ1X DN 4-[(3,5-diamino-1H-pyrazol-4-yl)diazenyl]phenol DMSKJ1X MI TTER6YH DMSKJ1X MN Casein kinase II alpha (CSNK2A1) DMSKJ1X MT DTT DMSKJ1X MA Inhibitor DMSKJ1X RN 4-arylazo-3,5-diamino-1H-pyrazole CDK inhibitors: SAR study, crystal structure in complex with CDK2, selectivity, and cellular effects. J Med Chem. 2006 Nov 2;49(22):6500-9. DMSKJ1X RU https://pubmed.ncbi.nlm.nih.gov/17064068 DMSKJ1X DI DMSKJ1X DMSKJ1X DN 4-[(3,5-diamino-1H-pyrazol-4-yl)diazenyl]phenol DMSKJ1X MI TTTU902 DMSKJ1X MN Checkpoint kinase-1 (CHK1) DMSKJ1X MT DTT DMSKJ1X MA Inhibitor DMSKJ1X RN 4-arylazo-3,5-diamino-1H-pyrazole CDK inhibitors: SAR study, crystal structure in complex with CDK2, selectivity, and cellular effects. J Med Chem. 2006 Nov 2;49(22):6500-9. DMSKJ1X RU https://pubmed.ncbi.nlm.nih.gov/17064068 DMSKJ1X DI DMSKJ1X DMSKJ1X DN 4-[(3,5-diamino-1H-pyrazol-4-yl)diazenyl]phenol DMSKJ1X MI TTAMQ62 DMSKJ1X MN Cyclin A2 (CCNA2) DMSKJ1X MT DTT DMSKJ1X MA Inhibitor DMSKJ1X RN 4-arylazo-3,5-diamino-1H-pyrazole CDK inhibitors: SAR study, crystal structure in complex with CDK2, selectivity, and cellular effects. J Med Chem. 2006 Nov 2;49(22):6500-9. DMSKJ1X RU https://pubmed.ncbi.nlm.nih.gov/17064068 DMSKJ1X DI DMSKJ1X DMSKJ1X DN 4-[(3,5-diamino-1H-pyrazol-4-yl)diazenyl]phenol DMSKJ1X MI TT7HF4W DMSKJ1X MN Cyclin-dependent kinase 2 (CDK2) DMSKJ1X MT DTT DMSKJ1X MA Inhibitor DMSKJ1X RN 4-arylazo-3,5-diamino-1H-pyrazole CDK inhibitors: SAR study, crystal structure in complex with CDK2, selectivity, and cellular effects. J Med Chem. 2006 Nov 2;49(22):6500-9. DMSKJ1X RU https://pubmed.ncbi.nlm.nih.gov/17064068 DMSKJ1X DI DMSKJ1X DMSKJ1X DN 4-[(3,5-diamino-1H-pyrazol-4-yl)diazenyl]phenol DMSKJ1X MI TT0PG8F DMSKJ1X MN Cyclin-dependent kinase 4 (CDK4) DMSKJ1X MT DTT DMSKJ1X MA Inhibitor DMSKJ1X RN 4-arylazo-3,5-diamino-1H-pyrazole CDK inhibitors: SAR study, crystal structure in complex with CDK2, selectivity, and cellular effects. J Med Chem. 2006 Nov 2;49(22):6500-9. DMSKJ1X RU https://pubmed.ncbi.nlm.nih.gov/17064068 DMSKJ1X DI DMSKJ1X DMSKJ1X DN 4-[(3,5-diamino-1H-pyrazol-4-yl)diazenyl]phenol DMSKJ1X MI TT1LVF2 DMSKJ1X MN Cyclin-dependent kinase 9 (CDK9) DMSKJ1X MT DTT DMSKJ1X MA Inhibitor DMSKJ1X RN 4-arylazo-3,5-diamino-1H-pyrazole CDK inhibitors: SAR study, crystal structure in complex with CDK2, selectivity, and cellular effects. J Med Chem. 2006 Nov 2;49(22):6500-9. DMSKJ1X RU https://pubmed.ncbi.nlm.nih.gov/17064068 DMSKJ1X DI DMSKJ1X DMSKJ1X DN 4-[(3,5-diamino-1H-pyrazol-4-yl)diazenyl]phenol DMSKJ1X MI TT4TQBX DMSKJ1X MN Extracellular signal-regulated kinase 2 (ERK2) DMSKJ1X MT DTT DMSKJ1X MA Inhibitor DMSKJ1X RN 4-arylazo-3,5-diamino-1H-pyrazole CDK inhibitors: SAR study, crystal structure in complex with CDK2, selectivity, and cellular effects. J Med Chem. 2006 Nov 2;49(22):6500-9. DMSKJ1X RU https://pubmed.ncbi.nlm.nih.gov/17064068 DMSKJ1X DI DMSKJ1X DMSKJ1X DN 4-[(3,5-diamino-1H-pyrazol-4-yl)diazenyl]phenol DMSKJ1X MI TTYVI76 DMSKJ1X MN Fungal Protein kinase A (Fung ypkA) DMSKJ1X MT DTT DMSKJ1X MA Inhibitor DMSKJ1X RN 4-arylazo-3,5-diamino-1H-pyrazole CDK inhibitors: SAR study, crystal structure in complex with CDK2, selectivity, and cellular effects. J Med Chem. 2006 Nov 2;49(22):6500-9. DMSKJ1X RU https://pubmed.ncbi.nlm.nih.gov/17064068 DMSKJ1X DI DMSKJ1X DMSKJ1X DN 4-[(3,5-diamino-1H-pyrazol-4-yl)diazenyl]phenol DMSKJ1X MI TTFCJ7S DMSKJ1X MN G1/S-specific cyclin-D1 (CCND1) DMSKJ1X MT DTT DMSKJ1X MA Inhibitor DMSKJ1X RN 4-arylazo-3,5-diamino-1H-pyrazole CDK inhibitors: SAR study, crystal structure in complex with CDK2, selectivity, and cellular effects. J Med Chem. 2006 Nov 2;49(22):6500-9. DMSKJ1X RU https://pubmed.ncbi.nlm.nih.gov/17064068 DMSKJ1X DI DMSKJ1X DMSKJ1X DN 4-[(3,5-diamino-1H-pyrazol-4-yl)diazenyl]phenol DMSKJ1X MI TTCEJ4F DMSKJ1X MN G1/S-specific cyclin-E1 (CCNE1) DMSKJ1X MT DTT DMSKJ1X MA Inhibitor DMSKJ1X RN 4-arylazo-3,5-diamino-1H-pyrazole CDK inhibitors: SAR study, crystal structure in complex with CDK2, selectivity, and cellular effects. J Med Chem. 2006 Nov 2;49(22):6500-9. DMSKJ1X RU https://pubmed.ncbi.nlm.nih.gov/17064068 DMSKJ1X DI DMSKJ1X DMSKJ1X DN 4-[(3,5-diamino-1H-pyrazol-4-yl)diazenyl]phenol DMSKJ1X MI TTRSMW9 DMSKJ1X MN Glycogen synthase kinase-3 beta (GSK-3B) DMSKJ1X MT DTT DMSKJ1X MA Inhibitor DMSKJ1X RN 4-arylazo-3,5-diamino-1H-pyrazole CDK inhibitors: SAR study, crystal structure in complex with CDK2, selectivity, and cellular effects. J Med Chem. 2006 Nov 2;49(22):6500-9. DMSKJ1X RU https://pubmed.ncbi.nlm.nih.gov/17064068 DMSKJ1X DI DMSKJ1X DMSKJ1X DN 4-[(3,5-diamino-1H-pyrazol-4-yl)diazenyl]phenol DMSKJ1X MI TT5U49F DMSKJ1X MN PRKACA messenger RNA (PRKACA mRNA) DMSKJ1X MT DTT DMSKJ1X MA Inhibitor DMSKJ1X RN 4-arylazo-3,5-diamino-1H-pyrazole CDK inhibitors: SAR study, crystal structure in complex with CDK2, selectivity, and cellular effects. J Med Chem. 2006 Nov 2;49(22):6500-9. DMSKJ1X RU https://pubmed.ncbi.nlm.nih.gov/17064068 DMSKJ1X DI DMSKJ1X DMSKJ1X DN 4-[(3,5-diamino-1H-pyrazol-4-yl)diazenyl]phenol DMSKJ1X MI TTWTSCV DMSKJ1X MN RAC-alpha serine/threonine-protein kinase (AKT1) DMSKJ1X MT DTT DMSKJ1X MA Inhibitor DMSKJ1X RN 4-arylazo-3,5-diamino-1H-pyrazole CDK inhibitors: SAR study, crystal structure in complex with CDK2, selectivity, and cellular effects. J Med Chem. 2006 Nov 2;49(22):6500-9. DMSKJ1X RU https://pubmed.ncbi.nlm.nih.gov/17064068 DMSKJ1X DI DMSKJ1X DMSKJ1X DN 4-[(3,5-diamino-1H-pyrazol-4-yl)diazenyl]phenol DMSKJ1X MI TTG0U4H DMSKJ1X MN Ribosomal protein S6 kinase beta-1 (S6K1) DMSKJ1X MT DTT DMSKJ1X MA Inhibitor DMSKJ1X RN 4-arylazo-3,5-diamino-1H-pyrazole CDK inhibitors: SAR study, crystal structure in complex with CDK2, selectivity, and cellular effects. J Med Chem. 2006 Nov 2;49(22):6500-9. DMSKJ1X RU https://pubmed.ncbi.nlm.nih.gov/17064068 DMSKJ1X DI DMSKJ1X DMSKJ1X DN 4-[(3,5-diamino-1H-pyrazol-4-yl)diazenyl]phenol DMSKJ1X MI TTQBR95 DMSKJ1X MN Stress-activated protein kinase 2a (p38 alpha) DMSKJ1X MT DTT DMSKJ1X MA Inhibitor DMSKJ1X RN 4-arylazo-3,5-diamino-1H-pyrazole CDK inhibitors: SAR study, crystal structure in complex with CDK2, selectivity, and cellular effects. J Med Chem. 2006 Nov 2;49(22):6500-9. DMSKJ1X RU https://pubmed.ncbi.nlm.nih.gov/17064068 DMSKJ1X DI DMSKJ1X DMSKJ1X DN 4-[(3,5-diamino-1H-pyrazol-4-yl)diazenyl]phenol DMSKJ1X MI TT3PJMV DMSKJ1X MN Tyrosine-protein kinase ABL1 (ABL) DMSKJ1X MT DTT DMSKJ1X MA Inhibitor DMSKJ1X RN 4-arylazo-3,5-diamino-1H-pyrazole CDK inhibitors: SAR study, crystal structure in complex with CDK2, selectivity, and cellular effects. J Med Chem. 2006 Nov 2;49(22):6500-9. DMSKJ1X RU https://pubmed.ncbi.nlm.nih.gov/17064068 DM04MK7 DI DM04MK7 DM04MK7 DN 4-[(3'-Hydroxybiphenyl-4-yl)methyl]pyridine DM04MK7 MI TTSZLWK DM04MK7 MN Aromatase (CYP19A1) DM04MK7 MT DTT DM04MK7 MA Inhibitor DM04MK7 RN Replacement of imidazolyl by pyridyl in biphenylmethylenes results in selective CYP17 and dual CYP17/CYP11B1 inhibitors for the treatment of prosta... J Med Chem. 2010 Aug 12;53(15):5749-58. DM04MK7 RU https://pubmed.ncbi.nlm.nih.gov/20684610 DM04MK7 DI DM04MK7 DM04MK7 DN 4-[(3'-Hydroxybiphenyl-4-yl)methyl]pyridine DM04MK7 MI TTIQUX7 DM04MK7 MN Steroid 11-beta-hydroxylase (CYP11B1) DM04MK7 MT DTT DM04MK7 MA Inhibitor DM04MK7 RN Replacement of imidazolyl by pyridyl in biphenylmethylenes results in selective CYP17 and dual CYP17/CYP11B1 inhibitors for the treatment of prosta... J Med Chem. 2010 Aug 12;53(15):5749-58. DM04MK7 RU https://pubmed.ncbi.nlm.nih.gov/20684610 DM04MK7 DI DM04MK7 DM04MK7 DN 4-[(3'-Hydroxybiphenyl-4-yl)methyl]pyridine DM04MK7 MI TTRA5BZ DM04MK7 MN Steroid 17-alpha-monooxygenase (S17AH) DM04MK7 MT DTT DM04MK7 MA Inhibitor DM04MK7 RN Replacement of imidazolyl by pyridyl in biphenylmethylenes results in selective CYP17 and dual CYP17/CYP11B1 inhibitors for the treatment of prosta... J Med Chem. 2010 Aug 12;53(15):5749-58. DM04MK7 RU https://pubmed.ncbi.nlm.nih.gov/20684610 DMIEMWA DI DMIEMWA DMIEMWA DN 4-[(4'-Hydroxybiphenyl-4-yl)methyl]pyridine DMIEMWA MI TTSZLWK DMIEMWA MN Aromatase (CYP19A1) DMIEMWA MT DTT DMIEMWA MA Inhibitor DMIEMWA RN Replacement of imidazolyl by pyridyl in biphenylmethylenes results in selective CYP17 and dual CYP17/CYP11B1 inhibitors for the treatment of prosta... J Med Chem. 2010 Aug 12;53(15):5749-58. DMIEMWA RU https://pubmed.ncbi.nlm.nih.gov/20684610 DMIEMWA DI DMIEMWA DMIEMWA DN 4-[(4'-Hydroxybiphenyl-4-yl)methyl]pyridine DMIEMWA MI TTIQUX7 DMIEMWA MN Steroid 11-beta-hydroxylase (CYP11B1) DMIEMWA MT DTT DMIEMWA MA Inhibitor DMIEMWA RN Replacement of imidazolyl by pyridyl in biphenylmethylenes results in selective CYP17 and dual CYP17/CYP11B1 inhibitors for the treatment of prosta... J Med Chem. 2010 Aug 12;53(15):5749-58. DMIEMWA RU https://pubmed.ncbi.nlm.nih.gov/20684610 DMIEMWA DI DMIEMWA DMIEMWA DN 4-[(4'-Hydroxybiphenyl-4-yl)methyl]pyridine DMIEMWA MI TTRA5BZ DMIEMWA MN Steroid 17-alpha-monooxygenase (S17AH) DMIEMWA MT DTT DMIEMWA MA Inhibitor DMIEMWA RN Replacement of imidazolyl by pyridyl in biphenylmethylenes results in selective CYP17 and dual CYP17/CYP11B1 inhibitors for the treatment of prosta... J Med Chem. 2010 Aug 12;53(15):5749-58. DMIEMWA RU https://pubmed.ncbi.nlm.nih.gov/20684610 DMNMC9O DI DMNMC9O DMNMC9O DN 4-[(5-methoxy-2-methylphenoxy)methyl]pyridine DMNMC9O MI TTQO71U DMNMC9O MN Hemoglobin (HB) DMNMC9O MT DTT DMNMC9O MA Inhibitor DMNMC9O RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DMNMC9O RU https://pubmed.ncbi.nlm.nih.gov/10592235 DMGRWEU DI DMGRWEU DMGRWEU DN 4-[(6-chloropyrazin-2-yl)amino]benzenesulfonamide DMGRWEU MI TT7HF4W DMGRWEU MN Cyclin-dependent kinase 2 (CDK2) DMGRWEU MT DTT DMGRWEU MA Inhibitor DMGRWEU RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DMGRWEU RU https://pubmed.ncbi.nlm.nih.gov/10592235 DMT1PM4 DI DMT1PM4 DMT1PM4 DN 4-[(diphenylmethyl)amino]-2-phenylquinazoline DMT1PM4 MI TT8DBY3 DMT1PM4 MN Angiotensin II receptor type-1 (AGTR1) DMT1PM4 MT DTT DMT1PM4 MA Antagonist DMT1PM4 RN Identification of a novel partial inhibitor of dopamine transporter among 4-substituted 2-phenylquinazolines. Bioorg Med Chem Lett. 2002 Aug 19;12(16):2225-8. DMT1PM4 RU https://pubmed.ncbi.nlm.nih.gov/12127543 DMT1PM4 DI DMT1PM4 DMT1PM4 DN 4-[(diphenylmethyl)amino]-2-phenylquinazoline DMT1PM4 MI TTVBI8W DMT1PM4 MN Dopamine transporter (DAT) DMT1PM4 MT DTT DMT1PM4 MA Inhibitor DMT1PM4 RN Identification of a novel partial inhibitor of dopamine transporter among 4-substituted 2-phenylquinazolines. Bioorg Med Chem Lett. 2002 Aug 19;12(16):2225-8. DMT1PM4 RU https://pubmed.ncbi.nlm.nih.gov/12127543 DMXKT6M DI DMXKT6M DMXKT6M DN 4-[(METHYLSULFONYL)AMINO]BENZOIC ACID DMXKT6M MI TTHI19T DMXKT6M MN Staphylococcus Beta-lactamase (Stap-coc blaZ) DMXKT6M MT DTT DMXKT6M MA Inhibitor DMXKT6M RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DMXKT6M RU https://pubmed.ncbi.nlm.nih.gov/10592235 DMTMLXU DI DMTMLXU DMTMLXU DN 4-[1-(4-hydroxyphenyl)-2-phenylbut-1-enyl]phenol DMTMLXU MI TTZAYWL DMTMLXU MN Estrogen receptor (ESR) DMTMLXU MT DTT DMTMLXU MA Inhibitor DMTMLXU RN Investigations on estrogen receptor binding. The estrogenic, antiestrogenic, and cytotoxic properties of C2-alkyl-substituted 1,1-bis(4-hydroxyphen... J Med Chem. 2002 Nov 21;45(24):5358-64. DMTMLXU RU https://pubmed.ncbi.nlm.nih.gov/12431063 DM30421 DI DM30421 DM30421 DN 4-[1-(4-hydroxyphenyl)-2-phenylhex-1-enyl]phenol DM30421 MI TTZAYWL DM30421 MN Estrogen receptor (ESR) DM30421 MT DTT DM30421 MA Inhibitor DM30421 RN Investigations on estrogen receptor binding. The estrogenic, antiestrogenic, and cytotoxic properties of C2-alkyl-substituted 1,1-bis(4-hydroxyphen... J Med Chem. 2002 Nov 21;45(24):5358-64. DM30421 RU https://pubmed.ncbi.nlm.nih.gov/12431063 DMWHKLA DI DMWHKLA DMWHKLA DN 4-[1-(4-hydroxyphenyl)-2-phenylpent-1-enyl]phenol DMWHKLA MI TTZAYWL DMWHKLA MN Estrogen receptor (ESR) DMWHKLA MT DTT DMWHKLA MA Inhibitor DMWHKLA RN Investigations on estrogen receptor binding. The estrogenic, antiestrogenic, and cytotoxic properties of C2-alkyl-substituted 1,1-bis(4-hydroxyphen... J Med Chem. 2002 Nov 21;45(24):5358-64. DMWHKLA RU https://pubmed.ncbi.nlm.nih.gov/12431063 DMH1I32 DI DMH1I32 DMH1I32 DN 4-[1-(4-hydroxyphenyl)-2-phenylprop-1-enyl]phenol DMH1I32 MI TTZAYWL DMH1I32 MN Estrogen receptor (ESR) DMH1I32 MT DTT DMH1I32 MA Inhibitor DMH1I32 RN Investigations on estrogen receptor binding. The estrogenic, antiestrogenic, and cytotoxic properties of C2-alkyl-substituted 1,1-bis(4-hydroxyphen... J Med Chem. 2002 Nov 21;45(24):5358-64. DMH1I32 RU https://pubmed.ncbi.nlm.nih.gov/12431063 DM4BFPE DI DM4BFPE DM4BFPE DN 4-[1-(4-hydroxyphenyl)-2-phenylvinyl]phenol DM4BFPE MI TTZAYWL DM4BFPE MN Estrogen receptor (ESR) DM4BFPE MT DTT DM4BFPE MA Inhibitor DM4BFPE RN Investigations on estrogen receptor binding. The estrogenic, antiestrogenic, and cytotoxic properties of C2-alkyl-substituted 1,1-bis(4-hydroxyphen... J Med Chem. 2002 Nov 21;45(24):5358-64. DM4BFPE RU https://pubmed.ncbi.nlm.nih.gov/12431063 DM8IYG1 DI DM8IYG1 DM8IYG1 DN 4-[1-(4-hydroxyphenyl)-3-methyl-1-butenyl]phenol DM8IYG1 MI TTFJ8Q1 DM8IYG1 MN Protein kinase C alpha (PRKCA) DM8IYG1 MT DTT DM8IYG1 MA Inhibitor DM8IYG1 RN Multivariate analysis by the minimum spanning tree method of the structural determinants of diphenylethylenes and triphenylacrylonitriles implicate... J Med Chem. 1992 Feb 7;35(3):573-83. DM8IYG1 RU https://pubmed.ncbi.nlm.nih.gov/1738150 DM8IYG1 DI DM8IYG1 DM8IYG1 DN 4-[1-(4-hydroxyphenyl)-3-methyl-1-butenyl]phenol DM8IYG1 MI TTYPXQF DM8IYG1 MN Protein kinase C beta (PRKCB) DM8IYG1 MT DTT DM8IYG1 MA Inhibitor DM8IYG1 RN Multivariate analysis by the minimum spanning tree method of the structural determinants of diphenylethylenes and triphenylacrylonitriles implicate... J Med Chem. 1992 Feb 7;35(3):573-83. DM8IYG1 RU https://pubmed.ncbi.nlm.nih.gov/1738150 DM8IYG1 DI DM8IYG1 DM8IYG1 DN 4-[1-(4-hydroxyphenyl)-3-methyl-1-butenyl]phenol DM8IYG1 MI TT9WJ8U DM8IYG1 MN Protein kinase C delta (PRKCD) DM8IYG1 MT DTT DM8IYG1 MA Inhibitor DM8IYG1 RN Multivariate analysis by the minimum spanning tree method of the structural determinants of diphenylethylenes and triphenylacrylonitriles implicate... J Med Chem. 1992 Feb 7;35(3):573-83. DM8IYG1 RU https://pubmed.ncbi.nlm.nih.gov/1738150 DM8IYG1 DI DM8IYG1 DM8IYG1 DN 4-[1-(4-hydroxyphenyl)-3-methyl-1-butenyl]phenol DM8IYG1 MI TTBZ7OD DM8IYG1 MN Protein kinase C epsilon (PRKCE) DM8IYG1 MT DTT DM8IYG1 MA Inhibitor DM8IYG1 RN Multivariate analysis by the minimum spanning tree method of the structural determinants of diphenylethylenes and triphenylacrylonitriles implicate... J Med Chem. 1992 Feb 7;35(3):573-83. DM8IYG1 RU https://pubmed.ncbi.nlm.nih.gov/1738150 DM8IYG1 DI DM8IYG1 DM8IYG1 DN 4-[1-(4-hydroxyphenyl)-3-methyl-1-butenyl]phenol DM8IYG1 MI TTRFOXJ DM8IYG1 MN Protein kinase C gamma (PRKCG) DM8IYG1 MT DTT DM8IYG1 MA Inhibitor DM8IYG1 RN Multivariate analysis by the minimum spanning tree method of the structural determinants of diphenylethylenes and triphenylacrylonitriles implicate... J Med Chem. 1992 Feb 7;35(3):573-83. DM8IYG1 RU https://pubmed.ncbi.nlm.nih.gov/1738150 DM8IYG1 DI DM8IYG1 DM8IYG1 DN 4-[1-(4-hydroxyphenyl)-3-methyl-1-butenyl]phenol DM8IYG1 MI TT8QL1J DM8IYG1 MN Protein kinase C theta (PRKCQ) DM8IYG1 MT DTT DM8IYG1 MA Inhibitor DM8IYG1 RN Multivariate analysis by the minimum spanning tree method of the structural determinants of diphenylethylenes and triphenylacrylonitriles implicate... J Med Chem. 1992 Feb 7;35(3):573-83. DM8IYG1 RU https://pubmed.ncbi.nlm.nih.gov/1738150 DM8IYG1 DI DM8IYG1 DM8IYG1 DN 4-[1-(4-hydroxyphenyl)-3-methyl-1-butenyl]phenol DM8IYG1 MI TTUWGRA DM8IYG1 MN Protein kinase C zeta (PRKCZ) DM8IYG1 MT DTT DM8IYG1 MA Inhibitor DM8IYG1 RN Multivariate analysis by the minimum spanning tree method of the structural determinants of diphenylethylenes and triphenylacrylonitriles implicate... J Med Chem. 1992 Feb 7;35(3):573-83. DM8IYG1 RU https://pubmed.ncbi.nlm.nih.gov/1738150 DMCEABJ DI DMCEABJ DMCEABJ DN 4-[1-(4'-Methoxybiphenyl-4-yl)propyl]pyridine DMCEABJ MI TTRA5BZ DMCEABJ MN Steroid 17-alpha-monooxygenase (S17AH) DMCEABJ MT DTT DMCEABJ MA Inhibitor DMCEABJ RN Replacement of imidazolyl by pyridyl in biphenylmethylenes results in selective CYP17 and dual CYP17/CYP11B1 inhibitors for the treatment of prosta... J Med Chem. 2010 Aug 12;53(15):5749-58. DMCEABJ RU https://pubmed.ncbi.nlm.nih.gov/20684610 DMW1IXY DI DMW1IXY DMW1IXY DN 4-[1,2-bis(4-hydroxyphenyl)but-1-enyl]phenol DMW1IXY MI TTZAYWL DMW1IXY MN Estrogen receptor (ESR) DMW1IXY MT DTT DMW1IXY MA Inhibitor DMW1IXY RN Antiestrogenically active 1,1,2-tris(4-hydroxyphenyl)alkenes without basic side chain: synthesis and biological activity. J Med Chem. 2003 Apr 10;46(8):1484-91. DMW1IXY RU https://pubmed.ncbi.nlm.nih.gov/12672249 DMW1IXY DI DMW1IXY DMW1IXY DN 4-[1,2-bis(4-hydroxyphenyl)but-1-enyl]phenol DMW1IXY MI TTOM3J0 DMW1IXY MN Estrogen receptor beta (ESR2) DMW1IXY MT DTT DMW1IXY MA Inhibitor DMW1IXY RN Antiestrogenically active 1,1,2-tris(4-hydroxyphenyl)alkenes without basic side chain: synthesis and biological activity. J Med Chem. 2003 Apr 10;46(8):1484-91. DMW1IXY RU https://pubmed.ncbi.nlm.nih.gov/12672249 DMTL6ES DI DMTL6ES DMTL6ES DN 4-[1,2-bis(4-hydroxyphenyl)hex-1-enyl]phenol DMTL6ES MI TTZAYWL DMTL6ES MN Estrogen receptor (ESR) DMTL6ES MT DTT DMTL6ES MA Inhibitor DMTL6ES RN Antiestrogenically active 1,1,2-tris(4-hydroxyphenyl)alkenes without basic side chain: synthesis and biological activity. J Med Chem. 2003 Apr 10;46(8):1484-91. DMTL6ES RU https://pubmed.ncbi.nlm.nih.gov/12672249 DMTL6ES DI DMTL6ES DMTL6ES DN 4-[1,2-bis(4-hydroxyphenyl)hex-1-enyl]phenol DMTL6ES MI TTOM3J0 DMTL6ES MN Estrogen receptor beta (ESR2) DMTL6ES MT DTT DMTL6ES MA Inhibitor DMTL6ES RN Antiestrogenically active 1,1,2-tris(4-hydroxyphenyl)alkenes without basic side chain: synthesis and biological activity. J Med Chem. 2003 Apr 10;46(8):1484-91. DMTL6ES RU https://pubmed.ncbi.nlm.nih.gov/12672249 DMTHG0Y DI DMTHG0Y DMTHG0Y DN 4-[1,2-bis(4-hydroxyphenyl)pent-1-enyl]phenol DMTHG0Y MI TTZAYWL DMTHG0Y MN Estrogen receptor (ESR) DMTHG0Y MT DTT DMTHG0Y MA Inhibitor DMTHG0Y RN Antiestrogenically active 1,1,2-tris(4-hydroxyphenyl)alkenes without basic side chain: synthesis and biological activity. J Med Chem. 2003 Apr 10;46(8):1484-91. DMTHG0Y RU https://pubmed.ncbi.nlm.nih.gov/12672249 DMTHG0Y DI DMTHG0Y DMTHG0Y DN 4-[1,2-bis(4-hydroxyphenyl)pent-1-enyl]phenol DMTHG0Y MI TTOM3J0 DMTHG0Y MN Estrogen receptor beta (ESR2) DMTHG0Y MT DTT DMTHG0Y MA Inhibitor DMTHG0Y RN Antiestrogenically active 1,1,2-tris(4-hydroxyphenyl)alkenes without basic side chain: synthesis and biological activity. J Med Chem. 2003 Apr 10;46(8):1484-91. DMTHG0Y RU https://pubmed.ncbi.nlm.nih.gov/12672249 DMR7GP6 DI DMR7GP6 DMR7GP6 DN 4-[1,2-bis(4-hydroxyphenyl)vinyl]phenol DMR7GP6 MI TTZAYWL DMR7GP6 MN Estrogen receptor (ESR) DMR7GP6 MT DTT DMR7GP6 MA Inhibitor DMR7GP6 RN Antiestrogenically active 1,1,2-tris(4-hydroxyphenyl)alkenes without basic side chain: synthesis and biological activity. J Med Chem. 2003 Apr 10;46(8):1484-91. DMR7GP6 RU https://pubmed.ncbi.nlm.nih.gov/12672249 DMR7GP6 DI DMR7GP6 DMR7GP6 DN 4-[1,2-bis(4-hydroxyphenyl)vinyl]phenol DMR7GP6 MI TTOM3J0 DMR7GP6 MN Estrogen receptor beta (ESR2) DMR7GP6 MT DTT DMR7GP6 MA Inhibitor DMR7GP6 RN Antiestrogenically active 1,1,2-tris(4-hydroxyphenyl)alkenes without basic side chain: synthesis and biological activity. J Med Chem. 2003 Apr 10;46(8):1484-91. DMR7GP6 RU https://pubmed.ncbi.nlm.nih.gov/12672249 DM08CG7 DI DM08CG7 DM08CG7 DN 4-[2-(2-Benzyl-phenoxy)-ethyl]-morpholine DM08CG7 MI TTZFYLI DM08CG7 MN Dopamine D1 receptor (D1R) DM08CG7 MT DTT DM08CG7 MA Inhibitor DM08CG7 RN Dopamine/serotonin receptor ligands. 9. Oxygen-containing midsized heterocyclic ring systems and nonrigidized analogues. A step toward dopamine D5 ... J Med Chem. 2004 Aug 12;47(17):4155-8. DM08CG7 RU https://pubmed.ncbi.nlm.nih.gov/15293986 DM08CG7 DI DM08CG7 DM08CG7 DN 4-[2-(2-Benzyl-phenoxy)-ethyl]-morpholine DM08CG7 MI TTE0A2F DM08CG7 MN Dopamine D4 receptor (D4R) DM08CG7 MT DTT DM08CG7 MA Inhibitor DM08CG7 RN Dopamine/serotonin receptor ligands. 9. Oxygen-containing midsized heterocyclic ring systems and nonrigidized analogues. A step toward dopamine D5 ... J Med Chem. 2004 Aug 12;47(17):4155-8. DM08CG7 RU https://pubmed.ncbi.nlm.nih.gov/15293986 DM08CG7 DI DM08CG7 DM08CG7 DN 4-[2-(2-Benzyl-phenoxy)-ethyl]-morpholine DM08CG7 MI TTS2PH3 DM08CG7 MN Dopamine D5 receptor (D5R) DM08CG7 MT DTT DM08CG7 MA Inhibitor DM08CG7 RN Dopamine/serotonin receptor ligands. 9. Oxygen-containing midsized heterocyclic ring systems and nonrigidized analogues. A step toward dopamine D5 ... J Med Chem. 2004 Aug 12;47(17):4155-8. DM08CG7 RU https://pubmed.ncbi.nlm.nih.gov/15293986 DMYESXB DI DMYESXB DMYESXB DN 4-[2-(2-Thienyl)acetamido]benzenesulfonamide DMYESXB MI TTUNARX DMYESXB MN Carbonic anhydrase (CA) DMYESXB MT DTT DMYESXB MA Inhibitor DMYESXB RN Carbonic anhydrase inhibitors. Aromatic/heterocyclic sulfonamides incorporating phenacetyl, pyridylacetyl and thienylacetyl tails act as potent inh... Bioorg Med Chem. 2009 Jul 15;17(14):4894-9. DMYESXB RU https://pubmed.ncbi.nlm.nih.gov/19539481 DMYESXB DI DMYESXB DMYESXB DN 4-[2-(2-Thienyl)acetamido]benzenesulfonamide DMYESXB MI TTHQPL7 DMYESXB MN Carbonic anhydrase I (CA-I) DMYESXB MT DTT DMYESXB MA Inhibitor DMYESXB RN Carbonic anhydrase inhibitors. Aromatic/heterocyclic sulfonamides incorporating phenacetyl, pyridylacetyl and thienylacetyl tails act as potent inh... Bioorg Med Chem. 2009 Jul 15;17(14):4894-9. DMYESXB RU https://pubmed.ncbi.nlm.nih.gov/19539481 DMYESXB DI DMYESXB DMYESXB DN 4-[2-(2-Thienyl)acetamido]benzenesulfonamide DMYESXB MI TTANPDJ DMYESXB MN Carbonic anhydrase II (CA-II) DMYESXB MT DTT DMYESXB MA Inhibitor DMYESXB RN Carbonic anhydrase inhibitors. Aromatic/heterocyclic sulfonamides incorporating phenacetyl, pyridylacetyl and thienylacetyl tails act as potent inh... Bioorg Med Chem. 2009 Jul 15;17(14):4894-9. DMYESXB RU https://pubmed.ncbi.nlm.nih.gov/19539481 DMH3UPO DI DMH3UPO DMH3UPO DN 4-[2-(2-Thienyl)acetamidoethyl]benzenesulfonamide DMH3UPO MI TTUNARX DMH3UPO MN Carbonic anhydrase (CA) DMH3UPO MT DTT DMH3UPO MA Inhibitor DMH3UPO RN Carbonic anhydrase inhibitors. Aromatic/heterocyclic sulfonamides incorporating phenacetyl, pyridylacetyl and thienylacetyl tails act as potent inh... Bioorg Med Chem. 2009 Jul 15;17(14):4894-9. DMH3UPO RU https://pubmed.ncbi.nlm.nih.gov/19539481 DMH3UPO DI DMH3UPO DMH3UPO DN 4-[2-(2-Thienyl)acetamidoethyl]benzenesulfonamide DMH3UPO MI TTHQPL7 DMH3UPO MN Carbonic anhydrase I (CA-I) DMH3UPO MT DTT DMH3UPO MA Inhibitor DMH3UPO RN Carbonic anhydrase inhibitors. Aromatic/heterocyclic sulfonamides incorporating phenacetyl, pyridylacetyl and thienylacetyl tails act as potent inh... Bioorg Med Chem. 2009 Jul 15;17(14):4894-9. DMH3UPO RU https://pubmed.ncbi.nlm.nih.gov/19539481 DMH3UPO DI DMH3UPO DMH3UPO DN 4-[2-(2-Thienyl)acetamidoethyl]benzenesulfonamide DMH3UPO MI TTANPDJ DMH3UPO MN Carbonic anhydrase II (CA-II) DMH3UPO MT DTT DMH3UPO MA Inhibitor DMH3UPO RN Carbonic anhydrase inhibitors. Aromatic/heterocyclic sulfonamides incorporating phenacetyl, pyridylacetyl and thienylacetyl tails act as potent inh... Bioorg Med Chem. 2009 Jul 15;17(14):4894-9. DMH3UPO RU https://pubmed.ncbi.nlm.nih.gov/19539481 DM4ENGI DI DM4ENGI DM4ENGI DN 4-[2-(3,5-Dimethoxy-phenyl)-vinyl]-pyridine DM4ENGI MI TTI84H7 DM4ENGI MN Cytochrome P450 1B1 (CYP1B1) DM4ENGI MT DTT DM4ENGI MA Inhibitor DM4ENGI RN Design, synthesis, and discovery of novel trans-stilbene analogues as potent and selective human cytochrome P450 1B1 inhibitors. J Med Chem. 2002 Jan 3;45(1):160-4. DM4ENGI RU https://pubmed.ncbi.nlm.nih.gov/11754588 DM64WSV DI DM64WSV DM64WSV DN 4-[2-(3-Phenyl-propylamino)-ethyl]-phenol DM64WSV MI TTLD29N DM64WSV MN Glutamate receptor ionotropic NMDA 1 (NMDAR1) DM64WSV MT DTT DM64WSV MA Inhibitor DM64WSV RN Structure-activity relationships for a series of bis(phenylalkyl)amines: potent subtype-selective inhibitors of N-methyl-D-aspartate receptors. J Med Chem. 1998 Aug 27;41(18):3499-506. DM64WSV RU https://pubmed.ncbi.nlm.nih.gov/9719603 DM64WSV DI DM64WSV DM64WSV DN 4-[2-(3-Phenyl-propylamino)-ethyl]-phenol DM64WSV MI TTN9D8E DM64WSV MN Glutamate receptor ionotropic NMDA 2B (NMDAR2B) DM64WSV MT DTT DM64WSV MA Inhibitor DM64WSV RN Structure-activity relationships for a series of bis(phenylalkyl)amines: potent subtype-selective inhibitors of N-methyl-D-aspartate receptors. J Med Chem. 1998 Aug 27;41(18):3499-506. DM64WSV RU https://pubmed.ncbi.nlm.nih.gov/9719603 DMGXM9C DI DMGXM9C DMGXM9C DN 4-[2-(3-Phenyl-ureido)-ethyl]-benzenesulfonamide DMGXM9C MI TTHQPL7 DMGXM9C MN Carbonic anhydrase I (CA-I) DMGXM9C MT DTT DMGXM9C MA Inhibitor DMGXM9C RN Carbonic anhydrase inhibitors: inhibition of the tumor-associated isozymes IX and XII with a library of aromatic and heteroaromatic sulfonamides. Bioorg Med Chem Lett. 2005 Nov 1;15(21):4862-6. DMGXM9C RU https://pubmed.ncbi.nlm.nih.gov/16168653 DMGXM9C DI DMGXM9C DMGXM9C DN 4-[2-(3-Phenyl-ureido)-ethyl]-benzenesulfonamide DMGXM9C MI TTANPDJ DMGXM9C MN Carbonic anhydrase II (CA-II) DMGXM9C MT DTT DMGXM9C MA Inhibitor DMGXM9C RN Carbonic anhydrase inhibitors: inhibition of the tumor-associated isozymes IX and XII with a library of aromatic and heteroaromatic sulfonamides. Bioorg Med Chem Lett. 2005 Nov 1;15(21):4862-6. DMGXM9C RU https://pubmed.ncbi.nlm.nih.gov/16168653 DMGXM9C DI DMGXM9C DMGXM9C DN 4-[2-(3-Phenyl-ureido)-ethyl]-benzenesulfonamide DMGXM9C MI TT2LVK8 DMGXM9C MN Carbonic anhydrase IX (CA-IX) DMGXM9C MT DTT DMGXM9C MA Inhibitor DMGXM9C RN Carbonic anhydrase inhibitors: inhibition of the tumor-associated isozymes IX and XII with a library of aromatic and heteroaromatic sulfonamides. Bioorg Med Chem Lett. 2005 Nov 1;15(21):4862-6. DMGXM9C RU https://pubmed.ncbi.nlm.nih.gov/16168653 DMGXM9C DI DMGXM9C DMGXM9C DN 4-[2-(3-Phenyl-ureido)-ethyl]-benzenesulfonamide DMGXM9C MI TTSYM0R DMGXM9C MN Carbonic anhydrase XII (CA-XII) DMGXM9C MT DTT DMGXM9C MA Inhibitor DMGXM9C RN Carbonic anhydrase inhibitors: inhibition of the tumor-associated isozymes IX and XII with a library of aromatic and heteroaromatic sulfonamides. Bioorg Med Chem Lett. 2005 Nov 1;15(21):4862-6. DMGXM9C RU https://pubmed.ncbi.nlm.nih.gov/16168653 DMDI32S DI DMDI32S DMDI32S DN 4-[2-(4-Benzylphenoxy)ethyl]pyridine DMDI32S MI TTXZEAJ DMDI32S MN Leukotriene A-4 hydrolase (LTA4H) DMDI32S MT DTT DMDI32S MA Inhibitor DMDI32S RN Discovery of 4-[(2S)-2-{[4-(4-chlorophenoxy)phenoxy]methyl}-1-pyrrolidinyl]butanoic acid (DG-051) as a novel leukotriene A4 hydrolase inhibitor of ... J Med Chem. 2010 Jan 28;53(2):573-85. DMDI32S RU https://pubmed.ncbi.nlm.nih.gov/19950900 DM74G6Q DI DM74G6Q DM74G6Q DN 4-[2-(4-Benzyl-piperidin-1-yl)-ethoxy]-phenol DM74G6Q MI TTLD29N DM74G6Q MN Glutamate receptor ionotropic NMDA 1 (NMDAR1) DM74G6Q MT DTT DM74G6Q MA Inhibitor DM74G6Q RN 4-Hydroxy-1-[2-(4-hydroxyphenoxy)ethyl]-4-(4-methylbenzyl)piperidine: a novel, potent, and selective NR1/2B NMDA receptor antagonist. J Med Chem. 1999 Jul 29;42(15):2993-3000. DM74G6Q RU https://pubmed.ncbi.nlm.nih.gov/10425109 DM74G6Q DI DM74G6Q DM74G6Q DN 4-[2-(4-Benzyl-piperidin-1-yl)-ethoxy]-phenol DM74G6Q MI TTN9D8E DM74G6Q MN Glutamate receptor ionotropic NMDA 2B (NMDAR2B) DM74G6Q MT DTT DM74G6Q MA Inhibitor DM74G6Q RN 4-Hydroxy-1-[2-(4-hydroxyphenoxy)ethyl]-4-(4-methylbenzyl)piperidine: a novel, potent, and selective NR1/2B NMDA receptor antagonist. J Med Chem. 1999 Jul 29;42(15):2993-3000. DM74G6Q RU https://pubmed.ncbi.nlm.nih.gov/10425109 DM9UGO0 DI DM9UGO0 DM9UGO0 DN 4-[2-(4-Imidazol-1-yl-phenoxy)-ethyl]-morpholine DM9UGO0 MI TTXV4FI DM9UGO0 MN Albendazole monooxygenase (CYP3A4) DM9UGO0 MT DTT DM9UGO0 MA Inhibitor DM9UGO0 RN Imidazole derivatives as new potent and selective 20-HETE synthase inhibitors. Bioorg Med Chem Lett. 2004 Jan 19;14(2):333-6. DM9UGO0 RU https://pubmed.ncbi.nlm.nih.gov/14698153 DM9UGO0 DI DM9UGO0 DM9UGO0 DN 4-[2-(4-Imidazol-1-yl-phenoxy)-ethyl]-morpholine DM9UGO0 MI TTVG215 DM9UGO0 MN Debrisoquine 4-hydroxylase (CYP2D6) DM9UGO0 MT DTT DM9UGO0 MA Inhibitor DM9UGO0 RN Imidazole derivatives as new potent and selective 20-HETE synthase inhibitors. Bioorg Med Chem Lett. 2004 Jan 19;14(2):333-6. DM9UGO0 RU https://pubmed.ncbi.nlm.nih.gov/14698153 DML8B3T DI DML8B3T DML8B3T DN 4-[2-(4-Phenyl-butoxy)-ethyl]-phenol DML8B3T MI TTLD29N DML8B3T MN Glutamate receptor ionotropic NMDA 1 (NMDAR1) DML8B3T MT DTT DML8B3T MA Inhibitor DML8B3T RN Structure-activity relationships for a series of bis(phenylalkyl)amines: potent subtype-selective inhibitors of N-methyl-D-aspartate receptors. J Med Chem. 1998 Aug 27;41(18):3499-506. DML8B3T RU https://pubmed.ncbi.nlm.nih.gov/9719603 DML8B3T DI DML8B3T DML8B3T DN 4-[2-(4-Phenyl-butoxy)-ethyl]-phenol DML8B3T MI TTN9D8E DML8B3T MN Glutamate receptor ionotropic NMDA 2B (NMDAR2B) DML8B3T MT DTT DML8B3T MA Inhibitor DML8B3T RN Structure-activity relationships for a series of bis(phenylalkyl)amines: potent subtype-selective inhibitors of N-methyl-D-aspartate receptors. J Med Chem. 1998 Aug 27;41(18):3499-506. DML8B3T RU https://pubmed.ncbi.nlm.nih.gov/9719603 DMXLVJW DI DMXLVJW DMXLVJW DN 4-[2-(4-Phenyl-butylamino)-ethyl]-phenol DMXLVJW MI TTLD29N DMXLVJW MN Glutamate receptor ionotropic NMDA 1 (NMDAR1) DMXLVJW MT DTT DMXLVJW MA Inhibitor DMXLVJW RN Structure-activity relationships for a series of bis(phenylalkyl)amines: potent subtype-selective inhibitors of N-methyl-D-aspartate receptors. J Med Chem. 1998 Aug 27;41(18):3499-506. DMXLVJW RU https://pubmed.ncbi.nlm.nih.gov/9719603 DMXLVJW DI DMXLVJW DMXLVJW DN 4-[2-(4-Phenyl-butylamino)-ethyl]-phenol DMXLVJW MI TTKJEMQ DMXLVJW MN Glutamate receptor ionotropic NMDA 2A (NMDAR2A) DMXLVJW MT DTT DMXLVJW MA Inhibitor DMXLVJW RN Structure-activity relationships for a series of bis(phenylalkyl)amines: potent subtype-selective inhibitors of N-methyl-D-aspartate receptors. J Med Chem. 1998 Aug 27;41(18):3499-506. DMXLVJW RU https://pubmed.ncbi.nlm.nih.gov/9719603 DMXLVJW DI DMXLVJW DMXLVJW DN 4-[2-(4-Phenyl-butylamino)-ethyl]-phenol DMXLVJW MI TTN9D8E DMXLVJW MN Glutamate receptor ionotropic NMDA 2B (NMDAR2B) DMXLVJW MT DTT DMXLVJW MA Inhibitor DMXLVJW RN Structure-activity relationships for a series of bis(phenylalkyl)amines: potent subtype-selective inhibitors of N-methyl-D-aspartate receptors. J Med Chem. 1998 Aug 27;41(18):3499-506. DMXLVJW RU https://pubmed.ncbi.nlm.nih.gov/9719603 DM8JM4Q DI DM8JM4Q DM8JM4Q DN 4-[2-(4-Phenyl-piperidin-1-yl)-ethoxy]-phenol DM8JM4Q MI TTLD29N DM8JM4Q MN Glutamate receptor ionotropic NMDA 1 (NMDAR1) DM8JM4Q MT DTT DM8JM4Q MA Inhibitor DM8JM4Q RN 4-Hydroxy-1-[2-(4-hydroxyphenoxy)ethyl]-4-(4-methylbenzyl)piperidine: a novel, potent, and selective NR1/2B NMDA receptor antagonist. J Med Chem. 1999 Jul 29;42(15):2993-3000. DM8JM4Q RU https://pubmed.ncbi.nlm.nih.gov/10425109 DM8JM4Q DI DM8JM4Q DM8JM4Q DN 4-[2-(4-Phenyl-piperidin-1-yl)-ethoxy]-phenol DM8JM4Q MI TTN9D8E DM8JM4Q MN Glutamate receptor ionotropic NMDA 2B (NMDAR2B) DM8JM4Q MT DTT DM8JM4Q MA Inhibitor DM8JM4Q RN 4-Hydroxy-1-[2-(4-hydroxyphenoxy)ethyl]-4-(4-methylbenzyl)piperidine: a novel, potent, and selective NR1/2B NMDA receptor antagonist. J Med Chem. 1999 Jul 29;42(15):2993-3000. DM8JM4Q RU https://pubmed.ncbi.nlm.nih.gov/10425109 DM5J7O8 DI DM5J7O8 DM5J7O8 DN 4-[2-(5-Phenyl-pentylamino)-ethyl]-phenol DM5J7O8 MI TTLD29N DM5J7O8 MN Glutamate receptor ionotropic NMDA 1 (NMDAR1) DM5J7O8 MT DTT DM5J7O8 MA Inhibitor DM5J7O8 RN Structure-activity relationships for a series of bis(phenylalkyl)amines: potent subtype-selective inhibitors of N-methyl-D-aspartate receptors. J Med Chem. 1998 Aug 27;41(18):3499-506. DM5J7O8 RU https://pubmed.ncbi.nlm.nih.gov/9719603 DM5J7O8 DI DM5J7O8 DM5J7O8 DN 4-[2-(5-Phenyl-pentylamino)-ethyl]-phenol DM5J7O8 MI TTKJEMQ DM5J7O8 MN Glutamate receptor ionotropic NMDA 2A (NMDAR2A) DM5J7O8 MT DTT DM5J7O8 MA Inhibitor DM5J7O8 RN Structure-activity relationships for a series of bis(phenylalkyl)amines: potent subtype-selective inhibitors of N-methyl-D-aspartate receptors. J Med Chem. 1998 Aug 27;41(18):3499-506. DM5J7O8 RU https://pubmed.ncbi.nlm.nih.gov/9719603 DM5J7O8 DI DM5J7O8 DM5J7O8 DN 4-[2-(5-Phenyl-pentylamino)-ethyl]-phenol DM5J7O8 MI TTN9D8E DM5J7O8 MN Glutamate receptor ionotropic NMDA 2B (NMDAR2B) DM5J7O8 MT DTT DM5J7O8 MA Inhibitor DM5J7O8 RN Structure-activity relationships for a series of bis(phenylalkyl)amines: potent subtype-selective inhibitors of N-methyl-D-aspartate receptors. J Med Chem. 1998 Aug 27;41(18):3499-506. DM5J7O8 RU https://pubmed.ncbi.nlm.nih.gov/9719603 DMLCIJX DI DMLCIJX DMLCIJX DN 4-[2-(6-Phenyl-hexylamino)-ethyl]-phenol DMLCIJX MI TTLD29N DMLCIJX MN Glutamate receptor ionotropic NMDA 1 (NMDAR1) DMLCIJX MT DTT DMLCIJX MA Inhibitor DMLCIJX RN Structure-activity relationships for a series of bis(phenylalkyl)amines: potent subtype-selective inhibitors of N-methyl-D-aspartate receptors. J Med Chem. 1998 Aug 27;41(18):3499-506. DMLCIJX RU https://pubmed.ncbi.nlm.nih.gov/9719603 DMLCIJX DI DMLCIJX DMLCIJX DN 4-[2-(6-Phenyl-hexylamino)-ethyl]-phenol DMLCIJX MI TTKJEMQ DMLCIJX MN Glutamate receptor ionotropic NMDA 2A (NMDAR2A) DMLCIJX MT DTT DMLCIJX MA Inhibitor DMLCIJX RN Structure-activity relationships for a series of bis(phenylalkyl)amines: potent subtype-selective inhibitors of N-methyl-D-aspartate receptors. J Med Chem. 1998 Aug 27;41(18):3499-506. DMLCIJX RU https://pubmed.ncbi.nlm.nih.gov/9719603 DMLCIJX DI DMLCIJX DMLCIJX DN 4-[2-(6-Phenyl-hexylamino)-ethyl]-phenol DMLCIJX MI TTN9D8E DMLCIJX MN Glutamate receptor ionotropic NMDA 2B (NMDAR2B) DMLCIJX MT DTT DMLCIJX MA Inhibitor DMLCIJX RN Structure-activity relationships for a series of bis(phenylalkyl)amines: potent subtype-selective inhibitors of N-methyl-D-aspartate receptors. J Med Chem. 1998 Aug 27;41(18):3499-506. DMLCIJX RU https://pubmed.ncbi.nlm.nih.gov/9719603 DMS0HV6 DI DMS0HV6 DMS0HV6 DN 4-[2,2-bis(4-hydroxyphenyl)-1-methylvinyl]phenol DMS0HV6 MI TTZAYWL DMS0HV6 MN Estrogen receptor (ESR) DMS0HV6 MT DTT DMS0HV6 MA Inhibitor DMS0HV6 RN Antiestrogenically active 1,1,2-tris(4-hydroxyphenyl)alkenes without basic side chain: synthesis and biological activity. J Med Chem. 2003 Apr 10;46(8):1484-91. DMS0HV6 RU https://pubmed.ncbi.nlm.nih.gov/12672249 DMS0HV6 DI DMS0HV6 DMS0HV6 DN 4-[2,2-bis(4-hydroxyphenyl)-1-methylvinyl]phenol DMS0HV6 MI TTOM3J0 DMS0HV6 MN Estrogen receptor beta (ESR2) DMS0HV6 MT DTT DMS0HV6 MA Inhibitor DMS0HV6 RN Antiestrogenically active 1,1,2-tris(4-hydroxyphenyl)alkenes without basic side chain: synthesis and biological activity. J Med Chem. 2003 Apr 10;46(8):1484-91. DMS0HV6 RU https://pubmed.ncbi.nlm.nih.gov/12672249 DMOPRQ7 DI DMOPRQ7 DMOPRQ7 DN 4-[3-(3-benzyloxy-pyridin-2-yl)-ureido]-benzamide DMOPRQ7 MI TTL2ADK DMOPRQ7 MN Rotamase A (PPIA) DMOPRQ7 MT DTT DMOPRQ7 MA Inhibitor DMOPRQ7 RN Structure-based design, synthesis, and biological evaluation of novel inhibitors of human cyclophilin A. J Med Chem. 2006 Feb 9;49(3):900-10. DMOPRQ7 RU https://pubmed.ncbi.nlm.nih.gov/16451056 DMFKRMG DI DMFKRMG DMFKRMG DN 4-[3-(4-Butyl-phenoxy)-propyl]-1H-imidazole DMFKRMG MI TT9JNIC DMFKRMG MN Histamine H3 receptor (H3R) DMFKRMG MT DTT DMFKRMG MA Inhibitor DMFKRMG RN Analogues and derivatives of ciproxifan, a novel prototype for generating potent histamine H3-receptor antagonists. Bioorg Med Chem Lett. 2000 Oct 16;10(20):2379-82. DMFKRMG RU https://pubmed.ncbi.nlm.nih.gov/11055360 DMJI6AM DI DMJI6AM DMJI6AM DN 4-[3-(4-CHLOROPHENYL)-1H-PYRAZOL-5-YL]PIPERIDINE DMJI6AM MI TT6L509 DMJI6AM MN Coagulation factor IIa (F2) DMJI6AM MT DTT DMJI6AM MA Inhibitor DMJI6AM RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DMJI6AM RU https://pubmed.ncbi.nlm.nih.gov/10592235 DMXBEYQ DI DMXBEYQ DMXBEYQ DN 4-[3-(4-Ethynyl-phenoxy)-propyl]-1H-imidazole DMXBEYQ MI TT9JNIC DMXBEYQ MN Histamine H3 receptor (H3R) DMXBEYQ MT DTT DMXBEYQ MA Inhibitor DMXBEYQ RN Analogues and derivatives of ciproxifan, a novel prototype for generating potent histamine H3-receptor antagonists. Bioorg Med Chem Lett. 2000 Oct 16;10(20):2379-82. DMXBEYQ RU https://pubmed.ncbi.nlm.nih.gov/11055360 DM7LV5A DI DM7LV5A DM7LV5A DN 4-[3-(4-Imidazol-1-yl-phenoxy)-propyl]-pyridine DM7LV5A MI TTXV4FI DM7LV5A MN Albendazole monooxygenase (CYP3A4) DM7LV5A MT DTT DM7LV5A MA Inhibitor DM7LV5A RN Imidazole derivatives as new potent and selective 20-HETE synthase inhibitors. Bioorg Med Chem Lett. 2004 Jan 19;14(2):333-6. DM7LV5A RU https://pubmed.ncbi.nlm.nih.gov/14698153 DM7LV5A DI DM7LV5A DM7LV5A DN 4-[3-(4-Imidazol-1-yl-phenoxy)-propyl]-pyridine DM7LV5A MI TTVG215 DM7LV5A MN Debrisoquine 4-hydroxylase (CYP2D6) DM7LV5A MT DTT DM7LV5A MA Inhibitor DM7LV5A RN Imidazole derivatives as new potent and selective 20-HETE synthase inhibitors. Bioorg Med Chem Lett. 2004 Jan 19;14(2):333-6. DM7LV5A RU https://pubmed.ncbi.nlm.nih.gov/14698153 DM4GU29 DI DM4GU29 DM4GU29 DN 4-[3-(4-Methoxy-phenoxy)-propyl]-1H-imidazole DM4GU29 MI TT9JNIC DM4GU29 MN Histamine H3 receptor (H3R) DM4GU29 MT DTT DM4GU29 MA Inhibitor DM4GU29 RN Different antagonist binding properties of human and rat histamine H3 receptors. Bioorg Med Chem Lett. 2001 Apr 9;11(7):951-4. DM4GU29 RU https://pubmed.ncbi.nlm.nih.gov/11294398 DMOF9YN DI DMOF9YN DMOF9YN DN 4-[3-(4-Phenyl-butylamino)-propyl]-phenol DMOF9YN MI TTLD29N DMOF9YN MN Glutamate receptor ionotropic NMDA 1 (NMDAR1) DMOF9YN MT DTT DMOF9YN MA Inhibitor DMOF9YN RN Structure-activity relationship for a series of 2-substituted 1,2,3,4-tetrahydro-9H-pyrido[3,4-b]indoles: potent subtype-selective inhibitors of N-... Bioorg Med Chem Lett. 1999 Jun 7;9(11):1619-24. DMOF9YN RU https://pubmed.ncbi.nlm.nih.gov/10386947 DMOF9YN DI DMOF9YN DMOF9YN DN 4-[3-(4-Phenyl-butylamino)-propyl]-phenol DMOF9YN MI TTKJEMQ DMOF9YN MN Glutamate receptor ionotropic NMDA 2A (NMDAR2A) DMOF9YN MT DTT DMOF9YN MA Inhibitor DMOF9YN RN Structure-activity relationships for a series of bis(phenylalkyl)amines: potent subtype-selective inhibitors of N-methyl-D-aspartate receptors. J Med Chem. 1998 Aug 27;41(18):3499-506. DMOF9YN RU https://pubmed.ncbi.nlm.nih.gov/9719603 DMOF9YN DI DMOF9YN DMOF9YN DN 4-[3-(4-Phenyl-butylamino)-propyl]-phenol DMOF9YN MI TTN9D8E DMOF9YN MN Glutamate receptor ionotropic NMDA 2B (NMDAR2B) DMOF9YN MT DTT DMOF9YN MA Inhibitor DMOF9YN RN Structure-activity relationship for a series of 2-substituted 1,2,3,4-tetrahydro-9H-pyrido[3,4-b]indoles: potent subtype-selective inhibitors of N-... Bioorg Med Chem Lett. 1999 Jun 7;9(11):1619-24. DMOF9YN RU https://pubmed.ncbi.nlm.nih.gov/10386947 DMKDBHN DI DMKDBHN DMKDBHN DN 4-[3-(5-Phenyl-pentylamino)-propyl]-phenol DMKDBHN MI TTLD29N DMKDBHN MN Glutamate receptor ionotropic NMDA 1 (NMDAR1) DMKDBHN MT DTT DMKDBHN MA Inhibitor DMKDBHN RN Structure-activity relationships for a series of bis(phenylalkyl)amines: potent subtype-selective inhibitors of N-methyl-D-aspartate receptors. J Med Chem. 1998 Aug 27;41(18):3499-506. DMKDBHN RU https://pubmed.ncbi.nlm.nih.gov/9719603 DMKDBHN DI DMKDBHN DMKDBHN DN 4-[3-(5-Phenyl-pentylamino)-propyl]-phenol DMKDBHN MI TTKJEMQ DMKDBHN MN Glutamate receptor ionotropic NMDA 2A (NMDAR2A) DMKDBHN MT DTT DMKDBHN MA Inhibitor DMKDBHN RN Structure-activity relationships for a series of bis(phenylalkyl)amines: potent subtype-selective inhibitors of N-methyl-D-aspartate receptors. J Med Chem. 1998 Aug 27;41(18):3499-506. DMKDBHN RU https://pubmed.ncbi.nlm.nih.gov/9719603 DMKDBHN DI DMKDBHN DMKDBHN DN 4-[3-(5-Phenyl-pentylamino)-propyl]-phenol DMKDBHN MI TTN9D8E DMKDBHN MN Glutamate receptor ionotropic NMDA 2B (NMDAR2B) DMKDBHN MT DTT DMKDBHN MA Inhibitor DMKDBHN RN Structure-activity relationships for a series of bis(phenylalkyl)amines: potent subtype-selective inhibitors of N-methyl-D-aspartate receptors. J Med Chem. 1998 Aug 27;41(18):3499-506. DMKDBHN RU https://pubmed.ncbi.nlm.nih.gov/9719603 DMZU23D DI DMZU23D DMZU23D DN 4-[3-(benzyloxy)benzoyl]benzoic acid DMZU23D MI TTT02K8 DMZU23D MN Steroid 5-alpha-reductase 2 (SRD5A2) DMZU23D MT DTT DMZU23D MA Inhibitor DMZU23D RN Novel 5alpha-reductase inhibitors: synthesis, structure-activity studies, and pharmacokinetic profile of phenoxybenzoylphenyl acetic acids. J Med Chem. 2006 Jan 26;49(2):748-59. DMZU23D RU https://pubmed.ncbi.nlm.nih.gov/16420060 DMTIA27 DI DMTIA27 DMTIA27 DN 4-[3-Hydroxyanilino]-6,7-Dimethoxyquinazoline DMTIA27 MI TT7HF4W DMTIA27 MN Cyclin-dependent kinase 2 (CDK2) DMTIA27 MT DTT DMTIA27 MA Inhibitor DMTIA27 RN DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Nucleic Acids Res. 2011 Jan;39(Database issue):D1035-41. DMTIA27 RU https://pubmed.ncbi.nlm.nih.gov/21059682 DMTIA27 DI DMTIA27 DMTIA27 DN 4-[3-Hydroxyanilino]-6,7-Dimethoxyquinazoline DMTIA27 MI TTUTJGQ DMTIA27 MN Vascular endothelial growth factor receptor 2 (KDR) DMTIA27 MT DTT DMTIA27 MA Inhibitor DMTIA27 RN Pharmacophore modeling and in silico screening for new KDR kinase inhibitors. Bioorg Med Chem Lett. 2007 Apr 15;17(8):2126-33. DMTIA27 RU https://pubmed.ncbi.nlm.nih.gov/17306530 DM62351 DI DM62351 DM62351 DN 4-[4-(6-methoxynaphthalen-2-yl)benzyl]pyridine DM62351 MI TTRA5BZ DM62351 MN Steroid 17-alpha-monooxygenase (S17AH) DM62351 MT DTT DM62351 MA Inhibitor DM62351 RN Replacement of imidazolyl by pyridyl in biphenylmethylenes results in selective CYP17 and dual CYP17/CYP11B1 inhibitors for the treatment of prosta... J Med Chem. 2010 Aug 12;53(15):5749-58. DM62351 RU https://pubmed.ncbi.nlm.nih.gov/20684610 DM8MVE9 DI DM8MVE9 DM8MVE9 DN 4-[4-(benzhydryloxy)benzoyl]benzoic acid DM8MVE9 MI TTTU72V DM8MVE9 MN Steroid 5-alpha-reductase 1 (SRD5A1) DM8MVE9 MT DTT DM8MVE9 MA Inhibitor DM8MVE9 RN Novel 5alpha-reductase inhibitors: synthesis, structure-activity studies, and pharmacokinetic profile of phenoxybenzoylphenyl acetic acids. J Med Chem. 2006 Jan 26;49(2):748-59. DM8MVE9 RU https://pubmed.ncbi.nlm.nih.gov/16420060 DM8MVE9 DI DM8MVE9 DM8MVE9 DN 4-[4-(benzhydryloxy)benzoyl]benzoic acid DM8MVE9 MI TTT02K8 DM8MVE9 MN Steroid 5-alpha-reductase 2 (SRD5A2) DM8MVE9 MT DTT DM8MVE9 MA Inhibitor DM8MVE9 RN Novel 5alpha-reductase inhibitors: synthesis, structure-activity studies, and pharmacokinetic profile of phenoxybenzoylphenyl acetic acids. J Med Chem. 2006 Jan 26;49(2):748-59. DM8MVE9 RU https://pubmed.ncbi.nlm.nih.gov/16420060 DM5Z64L DI DM5Z64L DM5Z64L DN 4-[4-(benzhydryloxy)piperidino]butyl benzoate DM5Z64L MI TT1RS9F DM5Z64L MN Acetylcholinesterase (AChE) DM5Z64L MT DTT DM5Z64L MA Inhibitor DM5Z64L RN Synthesis, in vitro assay, and molecular modeling of new piperidine derivatives having dual inhibitory potency against acetylcholinesterase and Abe... Bioorg Med Chem. 2007 Oct 15;15(20):6596-607. DM5Z64L RU https://pubmed.ncbi.nlm.nih.gov/17681794 DM9VPFL DI DM9VPFL DM9VPFL DN 4-[4-(benzoylamino)benzoyl]benzoic acid DM9VPFL MI TTT02K8 DM9VPFL MN Steroid 5-alpha-reductase 2 (SRD5A2) DM9VPFL MT DTT DM9VPFL MA Inhibitor DM9VPFL RN Novel 5alpha-reductase inhibitors: synthesis, structure-activity studies, and pharmacokinetic profile of phenoxybenzoylphenyl acetic acids. J Med Chem. 2006 Jan 26;49(2):748-59. DM9VPFL RU https://pubmed.ncbi.nlm.nih.gov/16420060 DMQC5EH DI DMQC5EH DMQC5EH DN 4-[4-(benzylamino)benzoyl]benzoic acid DMQC5EH MI TTT02K8 DMQC5EH MN Steroid 5-alpha-reductase 2 (SRD5A2) DMQC5EH MT DTT DMQC5EH MA Inhibitor DMQC5EH RN Novel 5alpha-reductase inhibitors: synthesis, structure-activity studies, and pharmacokinetic profile of phenoxybenzoylphenyl acetic acids. J Med Chem. 2006 Jan 26;49(2):748-59. DMQC5EH RU https://pubmed.ncbi.nlm.nih.gov/16420060 DMTDYHE DI DMTDYHE DMTDYHE DN 4-[4-(benzyloxy)piperidino]butyl benzoate DMTDYHE MI TTEB0GD DMTDYHE MN Cholinesterase (BCHE) DMTDYHE MT DTT DMTDYHE MA Inhibitor DMTDYHE RN Synthesis, in vitro assay, and molecular modeling of new piperidine derivatives having dual inhibitory potency against acetylcholinesterase and Abe... Bioorg Med Chem. 2007 Oct 15;15(20):6596-607. DMTDYHE RU https://pubmed.ncbi.nlm.nih.gov/17681794 DMIXRCS DI DMIXRCS DMIXRCS DN 4-[4-(benzyloxy)piperidino]butyl-3-chlorobenzoate DMIXRCS MI TTEB0GD DMIXRCS MN Cholinesterase (BCHE) DMIXRCS MT DTT DMIXRCS MA Inhibitor DMIXRCS RN Synthesis, in vitro assay, and molecular modeling of new piperidine derivatives having dual inhibitory potency against acetylcholinesterase and Abe... Bioorg Med Chem. 2007 Oct 15;15(20):6596-607. DMIXRCS RU https://pubmed.ncbi.nlm.nih.gov/17681794 DM87AYP DI DM87AYP DM87AYP DN 4-[4-(benzyloxy)piperidino]butyl-3-fluorobenzoate DM87AYP MI TTEB0GD DM87AYP MN Cholinesterase (BCHE) DM87AYP MT DTT DM87AYP MA Inhibitor DM87AYP RN Synthesis, in vitro assay, and molecular modeling of new piperidine derivatives having dual inhibitory potency against acetylcholinesterase and Abe... Bioorg Med Chem. 2007 Oct 15;15(20):6596-607. DM87AYP RU https://pubmed.ncbi.nlm.nih.gov/17681794 DM0V8MA DI DM0V8MA DM0V8MA DN 4-[4-(benzyloxy)piperidino]butyl-4-chlorobenzoate DM0V8MA MI TTEB0GD DM0V8MA MN Cholinesterase (BCHE) DM0V8MA MT DTT DM0V8MA MA Inhibitor DM0V8MA RN Synthesis, in vitro assay, and molecular modeling of new piperidine derivatives having dual inhibitory potency against acetylcholinesterase and Abe... Bioorg Med Chem. 2007 Oct 15;15(20):6596-607. DM0V8MA RU https://pubmed.ncbi.nlm.nih.gov/17681794 DML7UQ1 DI DML7UQ1 DML7UQ1 DN 4-[4-(benzyloxy)piperidino]butyl-4-fluorobenzoate DML7UQ1 MI TTEB0GD DML7UQ1 MN Cholinesterase (BCHE) DML7UQ1 MT DTT DML7UQ1 MA Inhibitor DML7UQ1 RN Synthesis, in vitro assay, and molecular modeling of new piperidine derivatives having dual inhibitory potency against acetylcholinesterase and Abe... Bioorg Med Chem. 2007 Oct 15;15(20):6596-607. DML7UQ1 RU https://pubmed.ncbi.nlm.nih.gov/17681794 DMNOD2Q DI DMNOD2Q DMNOD2Q DN 4-[4-(benzyloxy)piperidino]butyl-4-nitrobenzoate DMNOD2Q MI TTEB0GD DMNOD2Q MN Cholinesterase (BCHE) DMNOD2Q MT DTT DMNOD2Q MA Inhibitor DMNOD2Q RN Synthesis, in vitro assay, and molecular modeling of new piperidine derivatives having dual inhibitory potency against acetylcholinesterase and Abe... Bioorg Med Chem. 2007 Oct 15;15(20):6596-607. DMNOD2Q RU https://pubmed.ncbi.nlm.nih.gov/17681794 DMQ9IN4 DI DMQ9IN4 DMQ9IN4 DN 4-[4-benzyloxy)benzoyl]benzoic acid DMQ9IN4 MI TTTU72V DMQ9IN4 MN Steroid 5-alpha-reductase 1 (SRD5A1) DMQ9IN4 MT DTT DMQ9IN4 MA Inhibitor DMQ9IN4 RN Novel 5alpha-reductase inhibitors: synthesis, structure-activity studies, and pharmacokinetic profile of phenoxybenzoylphenyl acetic acids. J Med Chem. 2006 Jan 26;49(2):748-59. DMQ9IN4 RU https://pubmed.ncbi.nlm.nih.gov/16420060 DMQ9IN4 DI DMQ9IN4 DMQ9IN4 DN 4-[4-benzyloxy)benzoyl]benzoic acid DMQ9IN4 MI TTT02K8 DMQ9IN4 MN Steroid 5-alpha-reductase 2 (SRD5A2) DMQ9IN4 MT DTT DMQ9IN4 MA Inhibitor DMQ9IN4 RN Novel 5alpha-reductase inhibitors: synthesis, structure-activity studies, and pharmacokinetic profile of phenoxybenzoylphenyl acetic acids. J Med Chem. 2006 Jan 26;49(2):748-59. DMQ9IN4 RU https://pubmed.ncbi.nlm.nih.gov/16420060 DMK4ICB DI DMK4ICB DMK4ICB DN 4-[5-(3-Hydroxyphenyl)-2-thienyl)-2-methyl]phenol DMK4ICB MI TTXV4FI DMK4ICB MN Albendazole monooxygenase (CYP3A4) DMK4ICB MT DTT DMK4ICB MA Inhibitor DMK4ICB RN New insights into the SAR and binding modes of bis(hydroxyphenyl)thiophenes and -benzenes: influence of additional substituents on 17beta-hydroxyst... J Med Chem. 2009 Nov 12;52(21):6724-43. DMK4ICB RU https://pubmed.ncbi.nlm.nih.gov/19831396 DMK4ICB DI DMK4ICB DMK4ICB DN 4-[5-(3-Hydroxyphenyl)-2-thienyl)-2-methyl]phenol DMK4ICB MI TTVG215 DMK4ICB MN Debrisoquine 4-hydroxylase (CYP2D6) DMK4ICB MT DTT DMK4ICB MA Inhibitor DMK4ICB RN New insights into the SAR and binding modes of bis(hydroxyphenyl)thiophenes and -benzenes: influence of additional substituents on 17beta-hydroxyst... J Med Chem. 2009 Nov 12;52(21):6724-43. DMK4ICB RU https://pubmed.ncbi.nlm.nih.gov/19831396 DMK4ICB DI DMK4ICB DMK4ICB DN 4-[5-(3-Hydroxyphenyl)-2-thienyl)-2-methyl]phenol DMK4ICB MI TTIWB6L DMK4ICB MN Estradiol 17 beta-dehydrogenase 1 (17-beta-HSD1) DMK4ICB MT DTT DMK4ICB MA Inhibitor DMK4ICB RN New insights into the SAR and binding modes of bis(hydroxyphenyl)thiophenes and -benzenes: influence of additional substituents on 17beta-hydroxyst... J Med Chem. 2009 Nov 12;52(21):6724-43. DMK4ICB RU https://pubmed.ncbi.nlm.nih.gov/19831396 DMZHVFO DI DMZHVFO DMZHVFO DN 4-[5-(3-Hydroxyphenyl)-2-thienyl]benzene-1,2-diol DMZHVFO MI TTIWB6L DMZHVFO MN Estradiol 17 beta-dehydrogenase 1 (17-beta-HSD1) DMZHVFO MT DTT DMZHVFO MA Inhibitor DMZHVFO RN New insights into the SAR and binding modes of bis(hydroxyphenyl)thiophenes and -benzenes: influence of additional substituents on 17beta-hydroxyst... J Med Chem. 2009 Nov 12;52(21):6724-43. DMZHVFO RU https://pubmed.ncbi.nlm.nih.gov/19831396 DM7ERYJ DI DM7ERYJ DM7ERYJ DN 4-[5-(3-Hydroxyphenyl)-3-thienyl]-2-methylphenol DM7ERYJ MI TTXV4FI DM7ERYJ MN Albendazole monooxygenase (CYP3A4) DM7ERYJ MT DTT DM7ERYJ MA Inhibitor DM7ERYJ RN New insights into the SAR and binding modes of bis(hydroxyphenyl)thiophenes and -benzenes: influence of additional substituents on 17beta-hydroxyst... J Med Chem. 2009 Nov 12;52(21):6724-43. DM7ERYJ RU https://pubmed.ncbi.nlm.nih.gov/19831396 DM7ERYJ DI DM7ERYJ DM7ERYJ DN 4-[5-(3-Hydroxyphenyl)-3-thienyl]-2-methylphenol DM7ERYJ MI TTVG215 DM7ERYJ MN Debrisoquine 4-hydroxylase (CYP2D6) DM7ERYJ MT DTT DM7ERYJ MA Inhibitor DM7ERYJ RN New insights into the SAR and binding modes of bis(hydroxyphenyl)thiophenes and -benzenes: influence of additional substituents on 17beta-hydroxyst... J Med Chem. 2009 Nov 12;52(21):6724-43. DM7ERYJ RU https://pubmed.ncbi.nlm.nih.gov/19831396 DM7ERYJ DI DM7ERYJ DM7ERYJ DN 4-[5-(3-Hydroxyphenyl)-3-thienyl]-2-methylphenol DM7ERYJ MI TTIWB6L DM7ERYJ MN Estradiol 17 beta-dehydrogenase 1 (17-beta-HSD1) DM7ERYJ MT DTT DM7ERYJ MA Inhibitor DM7ERYJ RN New insights into the SAR and binding modes of bis(hydroxyphenyl)thiophenes and -benzenes: influence of additional substituents on 17beta-hydroxyst... J Med Chem. 2009 Nov 12;52(21):6724-43. DM7ERYJ RU https://pubmed.ncbi.nlm.nih.gov/19831396 DMI7YAQ DI DMI7YAQ DMI7YAQ DN 4-[5-Bromo-indan-(1E)-ylidenemethyl]-pyridine DMI7YAQ MI TTIQUX7 DMI7YAQ MN Steroid 11-beta-hydroxylase (CYP11B1) DMI7YAQ MT DTT DMI7YAQ MA Inhibitor DMI7YAQ RN Synthesis and evaluation of (pyridylmethylene)tetrahydronaphthalenes/-indanes and structurally modified derivatives: potent and selective inhibitor... J Med Chem. 2005 Mar 10;48(5):1563-75. DMI7YAQ RU https://pubmed.ncbi.nlm.nih.gov/15743198 DMI7YAQ DI DMI7YAQ DMI7YAQ DN 4-[5-Bromo-indan-(1E)-ylidenemethyl]-pyridine DMI7YAQ MI TTRA5BZ DMI7YAQ MN Steroid 17-alpha-monooxygenase (S17AH) DMI7YAQ MT DTT DMI7YAQ MA Inhibitor DMI7YAQ RN Synthesis and evaluation of (pyridylmethylene)tetrahydronaphthalenes/-indanes and structurally modified derivatives: potent and selective inhibitor... J Med Chem. 2005 Mar 10;48(5):1563-75. DMI7YAQ RU https://pubmed.ncbi.nlm.nih.gov/15743198 DMQKHXN DI DMQKHXN DMQKHXN DN 4-[5-Bromo-indan-(1Z)-ylidenemethyl]-pyridine DMQKHXN MI TTSZLWK DMQKHXN MN Aromatase (CYP19A1) DMQKHXN MT DTT DMQKHXN MA Inhibitor DMQKHXN RN Synthesis and evaluation of (pyridylmethylene)tetrahydronaphthalenes/-indanes and structurally modified derivatives: potent and selective inhibitor... J Med Chem. 2005 Mar 10;48(5):1563-75. DMQKHXN RU https://pubmed.ncbi.nlm.nih.gov/15743198 DMQKHXN DI DMQKHXN DMQKHXN DN 4-[5-Bromo-indan-(1Z)-ylidenemethyl]-pyridine DMQKHXN MI TTIQUX7 DMQKHXN MN Steroid 11-beta-hydroxylase (CYP11B1) DMQKHXN MT DTT DMQKHXN MA Inhibitor DMQKHXN RN Synthesis and evaluation of (pyridylmethylene)tetrahydronaphthalenes/-indanes and structurally modified derivatives: potent and selective inhibitor... J Med Chem. 2005 Mar 10;48(5):1563-75. DMQKHXN RU https://pubmed.ncbi.nlm.nih.gov/15743198 DMQKHXN DI DMQKHXN DMQKHXN DN 4-[5-Bromo-indan-(1Z)-ylidenemethyl]-pyridine DMQKHXN MI TTRA5BZ DMQKHXN MN Steroid 17-alpha-monooxygenase (S17AH) DMQKHXN MT DTT DMQKHXN MA Inhibitor DMQKHXN RN Synthesis and evaluation of (pyridylmethylene)tetrahydronaphthalenes/-indanes and structurally modified derivatives: potent and selective inhibitor... J Med Chem. 2005 Mar 10;48(5):1563-75. DMQKHXN RU https://pubmed.ncbi.nlm.nih.gov/15743198 DMZL8KN DI DMZL8KN DMZL8KN DN 4-[5-Chloro-indan-(1E)-ylidenemethyl]-pyridine DMZL8KN MI TTSZLWK DMZL8KN MN Aromatase (CYP19A1) DMZL8KN MT DTT DMZL8KN MA Inhibitor DMZL8KN RN Synthesis and evaluation of (pyridylmethylene)tetrahydronaphthalenes/-indanes and structurally modified derivatives: potent and selective inhibitor... J Med Chem. 2005 Mar 10;48(5):1563-75. DMZL8KN RU https://pubmed.ncbi.nlm.nih.gov/15743198 DMZL8KN DI DMZL8KN DMZL8KN DN 4-[5-Chloro-indan-(1E)-ylidenemethyl]-pyridine DMZL8KN MI TTIQUX7 DMZL8KN MN Steroid 11-beta-hydroxylase (CYP11B1) DMZL8KN MT DTT DMZL8KN MA Inhibitor DMZL8KN RN Synthesis and evaluation of (pyridylmethylene)tetrahydronaphthalenes/-indanes and structurally modified derivatives: potent and selective inhibitor... J Med Chem. 2005 Mar 10;48(5):1563-75. DMZL8KN RU https://pubmed.ncbi.nlm.nih.gov/15743198 DMZL8KN DI DMZL8KN DMZL8KN DN 4-[5-Chloro-indan-(1E)-ylidenemethyl]-pyridine DMZL8KN MI TTRA5BZ DMZL8KN MN Steroid 17-alpha-monooxygenase (S17AH) DMZL8KN MT DTT DMZL8KN MA Inhibitor DMZL8KN RN Synthesis and evaluation of (pyridylmethylene)tetrahydronaphthalenes/-indanes and structurally modified derivatives: potent and selective inhibitor... J Med Chem. 2005 Mar 10;48(5):1563-75. DMZL8KN RU https://pubmed.ncbi.nlm.nih.gov/15743198 DM1Z3DG DI DM1Z3DG DM1Z3DG DN 4-[5-Chloro-indan-(1Z)-ylidenemethyl]-pyridine DM1Z3DG MI TTSZLWK DM1Z3DG MN Aromatase (CYP19A1) DM1Z3DG MT DTT DM1Z3DG MA Inhibitor DM1Z3DG RN Synthesis and evaluation of (pyridylmethylene)tetrahydronaphthalenes/-indanes and structurally modified derivatives: potent and selective inhibitor... J Med Chem. 2005 Mar 10;48(5):1563-75. DM1Z3DG RU https://pubmed.ncbi.nlm.nih.gov/15743198 DM1Z3DG DI DM1Z3DG DM1Z3DG DN 4-[5-Chloro-indan-(1Z)-ylidenemethyl]-pyridine DM1Z3DG MI TTIQUX7 DM1Z3DG MN Steroid 11-beta-hydroxylase (CYP11B1) DM1Z3DG MT DTT DM1Z3DG MA Inhibitor DM1Z3DG RN Synthesis and evaluation of (pyridylmethylene)tetrahydronaphthalenes/-indanes and structurally modified derivatives: potent and selective inhibitor... J Med Chem. 2005 Mar 10;48(5):1563-75. DM1Z3DG RU https://pubmed.ncbi.nlm.nih.gov/15743198 DM1Z3DG DI DM1Z3DG DM1Z3DG DN 4-[5-Chloro-indan-(1Z)-ylidenemethyl]-pyridine DM1Z3DG MI TTRA5BZ DM1Z3DG MN Steroid 17-alpha-monooxygenase (S17AH) DM1Z3DG MT DTT DM1Z3DG MA Inhibitor DM1Z3DG RN Synthesis and evaluation of (pyridylmethylene)tetrahydronaphthalenes/-indanes and structurally modified derivatives: potent and selective inhibitor... J Med Chem. 2005 Mar 10;48(5):1563-75. DM1Z3DG RU https://pubmed.ncbi.nlm.nih.gov/15743198 DMY08FE DI DMY08FE DMY08FE DN 4-[5-Fluoro-indan-(1E)-ylidenemethyl]-pyridine DMY08FE MI TTSZLWK DMY08FE MN Aromatase (CYP19A1) DMY08FE MT DTT DMY08FE MA Inhibitor DMY08FE RN Synthesis and evaluation of (pyridylmethylene)tetrahydronaphthalenes/-indanes and structurally modified derivatives: potent and selective inhibitor... J Med Chem. 2005 Mar 10;48(5):1563-75. DMY08FE RU https://pubmed.ncbi.nlm.nih.gov/15743198 DMY08FE DI DMY08FE DMY08FE DN 4-[5-Fluoro-indan-(1E)-ylidenemethyl]-pyridine DMY08FE MI TTIQUX7 DMY08FE MN Steroid 11-beta-hydroxylase (CYP11B1) DMY08FE MT DTT DMY08FE MA Inhibitor DMY08FE RN Synthesis and evaluation of (pyridylmethylene)tetrahydronaphthalenes/-indanes and structurally modified derivatives: potent and selective inhibitor... J Med Chem. 2005 Mar 10;48(5):1563-75. DMY08FE RU https://pubmed.ncbi.nlm.nih.gov/15743198 DMY08FE DI DMY08FE DMY08FE DN 4-[5-Fluoro-indan-(1E)-ylidenemethyl]-pyridine DMY08FE MI TTRA5BZ DMY08FE MN Steroid 17-alpha-monooxygenase (S17AH) DMY08FE MT DTT DMY08FE MA Inhibitor DMY08FE RN Synthesis and evaluation of (pyridylmethylene)tetrahydronaphthalenes/-indanes and structurally modified derivatives: potent and selective inhibitor... J Med Chem. 2005 Mar 10;48(5):1563-75. DMY08FE RU https://pubmed.ncbi.nlm.nih.gov/15743198 DMHDZUO DI DMHDZUO DMHDZUO DN 4-[5-Fluoro-indan-(1Z)-ylidenemethyl]-pyridine DMHDZUO MI TTSZLWK DMHDZUO MN Aromatase (CYP19A1) DMHDZUO MT DTT DMHDZUO MA Inhibitor DMHDZUO RN Synthesis and evaluation of (pyridylmethylene)tetrahydronaphthalenes/-indanes and structurally modified derivatives: potent and selective inhibitor... J Med Chem. 2005 Mar 10;48(5):1563-75. DMHDZUO RU https://pubmed.ncbi.nlm.nih.gov/15743198 DMHDZUO DI DMHDZUO DMHDZUO DN 4-[5-Fluoro-indan-(1Z)-ylidenemethyl]-pyridine DMHDZUO MI TTIQUX7 DMHDZUO MN Steroid 11-beta-hydroxylase (CYP11B1) DMHDZUO MT DTT DMHDZUO MA Inhibitor DMHDZUO RN Synthesis and evaluation of (pyridylmethylene)tetrahydronaphthalenes/-indanes and structurally modified derivatives: potent and selective inhibitor... J Med Chem. 2005 Mar 10;48(5):1563-75. DMHDZUO RU https://pubmed.ncbi.nlm.nih.gov/15743198 DMHDZUO DI DMHDZUO DMHDZUO DN 4-[5-Fluoro-indan-(1Z)-ylidenemethyl]-pyridine DMHDZUO MI TTRA5BZ DMHDZUO MN Steroid 17-alpha-monooxygenase (S17AH) DMHDZUO MT DTT DMHDZUO MA Inhibitor DMHDZUO RN Synthesis and evaluation of (pyridylmethylene)tetrahydronaphthalenes/-indanes and structurally modified derivatives: potent and selective inhibitor... J Med Chem. 2005 Mar 10;48(5):1563-75. DMHDZUO RU https://pubmed.ncbi.nlm.nih.gov/15743198 DM25GS6 DI DM25GS6 DM25GS6 DN 4-[5-Methoxy-indan-(1E)-ylidenemethyl]-pyridine DM25GS6 MI TTSZLWK DM25GS6 MN Aromatase (CYP19A1) DM25GS6 MT DTT DM25GS6 MA Inhibitor DM25GS6 RN Synthesis and evaluation of (pyridylmethylene)tetrahydronaphthalenes/-indanes and structurally modified derivatives: potent and selective inhibitor... J Med Chem. 2005 Mar 10;48(5):1563-75. DM25GS6 RU https://pubmed.ncbi.nlm.nih.gov/15743198 DMLBX4Q DI DMLBX4Q DMLBX4Q DN 4-[5-Methoxy-indan-(1Z)-ylidenemethyl]-pyridine DMLBX4Q MI TTSZLWK DMLBX4Q MN Aromatase (CYP19A1) DMLBX4Q MT DTT DMLBX4Q MA Inhibitor DMLBX4Q RN Synthesis and evaluation of (pyridylmethylene)tetrahydronaphthalenes/-indanes and structurally modified derivatives: potent and selective inhibitor... J Med Chem. 2005 Mar 10;48(5):1563-75. DMLBX4Q RU https://pubmed.ncbi.nlm.nih.gov/15743198 DM3IR8Y DI DM3IR8Y DM3IR8Y DN 4-[6-Methoxy-indan-(1E)-ylidenemethyl]-pyridine DM3IR8Y MI TTSZLWK DM3IR8Y MN Aromatase (CYP19A1) DM3IR8Y MT DTT DM3IR8Y MA Inhibitor DM3IR8Y RN Synthesis and evaluation of (pyridylmethylene)tetrahydronaphthalenes/-indanes and structurally modified derivatives: potent and selective inhibitor... J Med Chem. 2005 Mar 10;48(5):1563-75. DM3IR8Y RU https://pubmed.ncbi.nlm.nih.gov/15743198 DMIBZJC DI DMIBZJC DMIBZJC DN 4-[6-Methoxy-indan-(1Z)-ylidenemethyl]-pyridine DMIBZJC MI TTSZLWK DMIBZJC MN Aromatase (CYP19A1) DMIBZJC MT DTT DMIBZJC MA Inhibitor DMIBZJC RN Synthesis and evaluation of (pyridylmethylene)tetrahydronaphthalenes/-indanes and structurally modified derivatives: potent and selective inhibitor... J Med Chem. 2005 Mar 10;48(5):1563-75. DMIBZJC RU https://pubmed.ncbi.nlm.nih.gov/15743198 DMYGN1K DI DMYGN1K DMYGN1K DN 4-[6-Methyl-indan-(1E)-ylidenemethyl]-pyridine DMYGN1K MI TTSZLWK DMYGN1K MN Aromatase (CYP19A1) DMYGN1K MT DTT DMYGN1K MA Inhibitor DMYGN1K RN Synthesis and evaluation of (pyridylmethylene)tetrahydronaphthalenes/-indanes and structurally modified derivatives: potent and selective inhibitor... J Med Chem. 2005 Mar 10;48(5):1563-75. DMYGN1K RU https://pubmed.ncbi.nlm.nih.gov/15743198 DM5VN3D DI DM5VN3D DM5VN3D DN 4-[6-Methyl-indan-(1Z)-ylidenemethyl]-pyridine DM5VN3D MI TTSZLWK DM5VN3D MN Aromatase (CYP19A1) DM5VN3D MT DTT DM5VN3D MA Inhibitor DM5VN3D RN Synthesis and evaluation of (pyridylmethylene)tetrahydronaphthalenes/-indanes and structurally modified derivatives: potent and selective inhibitor... J Med Chem. 2005 Mar 10;48(5):1563-75. DM5VN3D RU https://pubmed.ncbi.nlm.nih.gov/15743198 DMMGHNA DI DMMGHNA DMMGHNA DN 4-{2-[(3-Nitrobenzoyl)Amino]Phenoxy}Phthalic Acid DMMGHNA MI TTZHY6R DMMGHNA MN Glycogen phosphorylase muscle form (GP) DMMGHNA MT DTT DMMGHNA MA Inhibitor DMMGHNA RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DMMGHNA RU https://pubmed.ncbi.nlm.nih.gov/10592235 DMA21GM DI DMA21GM DMA21GM DN 4-{2-[Ethyl-(4-phenyl-butyl)-amino]-ethyl}-phenol DMA21GM MI TTLD29N DMA21GM MN Glutamate receptor ionotropic NMDA 1 (NMDAR1) DMA21GM MT DTT DMA21GM MA Inhibitor DMA21GM RN Structure-activity relationships for a series of bis(phenylalkyl)amines: potent subtype-selective inhibitors of N-methyl-D-aspartate receptors. J Med Chem. 1998 Aug 27;41(18):3499-506. DMA21GM RU https://pubmed.ncbi.nlm.nih.gov/9719603 DMA21GM DI DMA21GM DMA21GM DN 4-{2-[Ethyl-(4-phenyl-butyl)-amino]-ethyl}-phenol DMA21GM MI TTN9D8E DMA21GM MN Glutamate receptor ionotropic NMDA 2B (NMDAR2B) DMA21GM MT DTT DMA21GM MA Inhibitor DMA21GM RN Structure-activity relationships for a series of bis(phenylalkyl)amines: potent subtype-selective inhibitors of N-methyl-D-aspartate receptors. J Med Chem. 1998 Aug 27;41(18):3499-506. DMA21GM RU https://pubmed.ncbi.nlm.nih.gov/9719603 DMZUM95 DI DMZUM95 DMZUM95 DN 4-{4-[(aminosulfonyl)oxy]benzoyl}phenyl sulfamate DMZUM95 MI TTHM0R1 DMZUM95 MN Steryl-sulfatase (STS) DMZUM95 MT DTT DMZUM95 MA Inhibitor DMZUM95 RN Chiral aromatase and dual aromatase-steroid sulfatase inhibitors from the letrozole template: synthesis, absolute configuration, and in vitro activ... J Med Chem. 2008 Jul 24;51(14):4226-38. DMZUM95 RU https://pubmed.ncbi.nlm.nih.gov/18590272 DMLE0I7 DI DMLE0I7 DMLE0I7 DN 4557W DMLE0I7 MI TTGKNB4 DMLE0I7 MN Epidermal growth factor receptor (EGFR) DMLE0I7 MT DTT DMLE0I7 MA Inhibitor DMLE0I7 RN Indazolylamino quinazolines and pyridopyrimidines as inhibitors of the EGFr and C-erbB-2. Bioorg Med Chem Lett. 2001 Jun 4;11(11):1401-5. DMLE0I7 RU https://pubmed.ncbi.nlm.nih.gov/11378364 DMLE0I7 DI DMLE0I7 DMLE0I7 DN 4557W DMLE0I7 MI TTR5TV4 DMLE0I7 MN ERBB2 messenger RNA (HER2 mRNA) DMLE0I7 MT DTT DMLE0I7 MA Inhibitor DMLE0I7 RN Indazolylamino quinazolines and pyridopyrimidines as inhibitors of the EGFr and C-erbB-2. Bioorg Med Chem Lett. 2001 Jun 4;11(11):1401-5. DMLE0I7 RU https://pubmed.ncbi.nlm.nih.gov/11378364 DMN2TMS DI DMN2TMS DMN2TMS DN 4-acrylamido-N-(3-bromophenyl)-2-hydroxybenzamide DMN2TMS MI TTGKNB4 DMN2TMS MN Epidermal growth factor receptor (EGFR) DMN2TMS MT DTT DMN2TMS MA Inhibitor DMN2TMS RN Acryloylamino-salicylanilides as EGFR PTK inhibitors. Bioorg Med Chem Lett. 2006 Jan 15;16(2):469-72. DMN2TMS RU https://pubmed.ncbi.nlm.nih.gov/16275081 DME24LV DI DME24LV DME24LV DN 4-adamantyl resorcinol DME24LV MI TTULVH8 DME24LV MN Tyrosinase (TYR) DME24LV MT DTT DME24LV MA Inhibitor DME24LV RN Studies on depigmenting activities of dihydroxyl benzamide derivatives containing adamantane moiety. Bioorg Med Chem Lett. 2009 Mar 1;19(5):1532-3. DME24LV RU https://pubmed.ncbi.nlm.nih.gov/19181523 DM9WT8M DI DM9WT8M DM9WT8M DN 4-Allyl-6-nitro-2-piperazin-1-yl-quinoline DM9WT8M MI TT3ROYC DM9WT8M MN Serotonin transporter (SERT) DM9WT8M MT DTT DM9WT8M MA Inhibitor DM9WT8M RN Syntheses and binding affinities of 6-nitroquipazine analogues for serotonin transporter. Part 2: 4-substituted 6-nitroquipazines. Bioorg Med Chem Lett. 2002 Mar 11;12(5):811-5. DM9WT8M RU https://pubmed.ncbi.nlm.nih.gov/11859009 DMGYK25 DI DMGYK25 DMGYK25 DN 4ALPHA-(HYDROXYMETHYL)-4ALPHA-DEMETHYLTERRITREM B DMGYK25 MI TT1RS9F DMGYK25 MN Acetylcholinesterase (AChE) DMGYK25 MT DTT DMGYK25 MA Inhibitor DMGYK25 RN Structure and anti-acetylcholinesterase activity of 4 alpha-(hydroxymethyl)-4 alpha-demethylterritrem B. J Nat Prod. 1997 Aug;60(8):842-3. DMGYK25 RU https://pubmed.ncbi.nlm.nih.gov/9287420 DMTSPLX DI DMTSPLX DMTSPLX DN 4alpha-PDD DMTSPLX MI TTKP2SU DMTSPLX MN Transient receptor potential cation channel V4 (TRPV4) DMTSPLX MT DTT DMTSPLX MA Activator DMTSPLX RN Activation of TRPV4 channels (hVRL-2/mTRP12) by phorbol derivatives. J Biol Chem. 2002 Apr 19;277(16):13569-77. DMTSPLX RU https://pubmed.ncbi.nlm.nih.gov/11827975 DMUOLES DI DMUOLES DMUOLES DN 4alpha-PDH DMUOLES MI TTKP2SU DMUOLES MN Transient receptor potential cation channel V4 (TRPV4) DMUOLES MT DTT DMUOLES MA Activator DMUOLES RN Modulation of the transient receptor potential vanilloid channel TRPV4 by 4alpha-phorbol esters: a structure-activity study. J Med Chem. 2009 May 14;52(9):2933-9. DMUOLES RU https://pubmed.ncbi.nlm.nih.gov/19361196 DMYNASR DI DMYNASR DMYNASR DN 4-AMBA DMYNASR MI TT5LF3C DMYNASR MN Solute carrier family 15 member 1 (SLC15A1) DMYNASR MT DTT DMYNASR MA Inhibitor DMYNASR RN Activation of vagal afferents in the rat duodenum by protein digests requires PepT1. J Nutr. 2005 Jun;135(6):1491-5. DMYNASR RU https://pubmed.ncbi.nlm.nih.gov/15930458 DMYX34S DI DMYX34S DMYX34S DN 4-Amino Hexanoic Acid DMYX34S MI TTT2LD9 DMYX34S MN GABA transaminase (ABAT) DMYX34S MT DTT DMYX34S MA Inhibitor DMYX34S RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMYX34S RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMNXSM2 DI DMNXSM2 DMNXSM2 DN 4-amino-1,2,5-oxadiazole-3-carboximidamide DMNXSM2 MI TTZJYKH DMNXSM2 MN Indoleamine 2,3-dioxygenase 1 (IDO1) DMNXSM2 MT DTT DMNXSM2 MA Inhibitor DMNXSM2 RN Discovery of potent competitive inhibitors of indoleamine 2,3-dioxygenase with in vivo pharmacodynamic activity and efficacy in a mouse melanoma mo... J Med Chem. 2009 Dec 10;52(23):7364-7. DMNXSM2 RU https://pubmed.ncbi.nlm.nih.gov/19507862 DMU49H6 DI DMU49H6 DMU49H6 DN 4-amino-1,8-naphthalimide DMU49H6 MI TTVDSZ0 DMU49H6 MN Poly [ADP-ribose] polymerase 1 (PARP1) DMU49H6 MT DTT DMU49H6 MA Inhibitor DMU49H6 RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DMU49H6 RU https://pubmed.ncbi.nlm.nih.gov/10592235 DM7X59V DI DM7X59V DM7X59V DN 4-Amino-2,6-diphenyl-pyrimidine-5-carbonitrile DM7X59V MI TTK25J1 DM7X59V MN Adenosine A1 receptor (ADORA1) DM7X59V MT DTT DM7X59V MA Inhibitor DM7X59V RN A new generation of adenosine receptor antagonists: from di- to trisubstituted aminopyrimidines. Bioorg Med Chem. 2008 Mar 15;16(6):2741-52. DM7X59V RU https://pubmed.ncbi.nlm.nih.gov/18258439 DM7X59V DI DM7X59V DM7X59V DN 4-Amino-2,6-diphenyl-pyrimidine-5-carbonitrile DM7X59V MI TTM2AOE DM7X59V MN Adenosine A2a receptor (ADORA2A) DM7X59V MT DTT DM7X59V MA Inhibitor DM7X59V RN A new generation of adenosine receptor antagonists: from di- to trisubstituted aminopyrimidines. Bioorg Med Chem. 2008 Mar 15;16(6):2741-52. DM7X59V RU https://pubmed.ncbi.nlm.nih.gov/18258439 DMINUHD DI DMINUHD DMINUHD DN 4-Amino-2-Deoxy-2,3-Dehydro-N-Neuraminic Acid DMINUHD MI TT50QJ3 DMINUHD MN Influenza Neuraminidase (Influ NA) DMINUHD MT DTT DMINUHD MA Inhibitor DMINUHD RN DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Nucleic Acids Res. 2011 Jan;39(Database issue):D1035-41. DMINUHD RU https://pubmed.ncbi.nlm.nih.gov/21059682 DM3MUF1 DI DM3MUF1 DM3MUF1 DN 4-amino-2H-chromen-2-one DM3MUF1 MI TT8XK6L DM3MUF1 MN Quinone reductase 1 (NQO1) DM3MUF1 MT DTT DM3MUF1 MA Inhibitor DM3MUF1 RN Coumarin-based inhibitors of human NAD(P)H:quinone oxidoreductase-1. Identification, structure-activity, off-target effects and in vitro human panc... J Med Chem. 2007 Dec 13;50(25):6316-25. DM3MUF1 RU https://pubmed.ncbi.nlm.nih.gov/17999461 DMOJTZD DI DMOJTZD DMOJTZD DN 4-amino-2-p-tolylisoindoline-1,3-dione DMOJTZD MI TTM2AOE DMOJTZD MN Adenosine A2a receptor (ADORA2A) DMOJTZD MT DTT DMOJTZD MA Inhibitor DMOJTZD RN Structure-based discovery of novel chemotypes for adenosine A(2A) receptor antagonists. J Med Chem. 2010 Feb 25;53(4):1799-809. DMOJTZD RU https://pubmed.ncbi.nlm.nih.gov/20095623 DMIX81A DI DMIX81A DMIX81A DN 4-Amino-3-(2-chloro-phenyl)-butyric acid DMIX81A MI TTDCVZW DMIX81A MN Gamma-aminobutyric acid B receptor (GABBR) DMIX81A MT DTT DMIX81A MA Inhibitor DMIX81A RN 3-Thienyl- and 3-furylaminobutyric acids. Synthesis and binding GABAB receptor studies. J Med Chem. 1991 Aug;34(8):2557-60. DMIX81A RU https://pubmed.ncbi.nlm.nih.gov/1652022 DMGI0YV DI DMGI0YV DMGI0YV DN 4-amino-3-(4-(hexyloxy)phenyl)-4-oxobutanoic acid DMGI0YV MI TTHY57M DMGI0YV MN Matrix metalloproteinase-13 (MMP-13) DMGI0YV MT DTT DMGI0YV MA Inhibitor DMGI0YV RN Ranking the selectivity of PubChem screening hits by activity-based protein profiling: MMP13 as a case study. Bioorg Med Chem. 2009 Feb 1;17(3):1101-8. DMGI0YV RU https://pubmed.ncbi.nlm.nih.gov/18364257 DMGI0YV DI DMGI0YV DMGI0YV DN 4-amino-3-(4-(hexyloxy)phenyl)-4-oxobutanoic acid DMGI0YV MI TTGA1IV DMGI0YV MN Matrix metalloproteinase-8 (MMP-8) DMGI0YV MT DTT DMGI0YV MA Inhibitor DMGI0YV RN Ranking the selectivity of PubChem screening hits by activity-based protein profiling: MMP13 as a case study. Bioorg Med Chem. 2009 Feb 1;17(3):1101-8. DMGI0YV RU https://pubmed.ncbi.nlm.nih.gov/18364257 DMGI0YV DI DMGI0YV DMGI0YV DN 4-amino-3-(4-(hexyloxy)phenyl)-4-oxobutanoic acid DMGI0YV MI TT6X50U DMGI0YV MN Matrix metalloproteinase-9 (MMP-9) DMGI0YV MT DTT DMGI0YV MA Inhibitor DMGI0YV RN Ranking the selectivity of PubChem screening hits by activity-based protein profiling: MMP13 as a case study. Bioorg Med Chem. 2009 Feb 1;17(3):1101-8. DMGI0YV RU https://pubmed.ncbi.nlm.nih.gov/18364257 DMVKPF1 DI DMVKPF1 DMVKPF1 DN 4-Amino-3-(4-fluoro-phenyl)-butyric acid DMVKPF1 MI TTDCVZW DMVKPF1 MN Gamma-aminobutyric acid B receptor (GABBR) DMVKPF1 MT DTT DMVKPF1 MA Inhibitor DMVKPF1 RN 3-Thienyl- and 3-furylaminobutyric acids. Synthesis and binding GABAB receptor studies. J Med Chem. 1991 Aug;34(8):2557-60. DMVKPF1 RU https://pubmed.ncbi.nlm.nih.gov/1652022 DMTO8NV DI DMTO8NV DMTO8NV DN 4-Amino-3-(5-bromo-thiophen-2-yl)-butyric acid DMTO8NV MI TTDCVZW DMTO8NV MN Gamma-aminobutyric acid B receptor (GABBR) DMTO8NV MT DTT DMTO8NV MA Inhibitor DMTO8NV RN 3-Thienyl- and 3-furylaminobutyric acids. Synthesis and binding GABAB receptor studies. J Med Chem. 1991 Aug;34(8):2557-60. DMTO8NV RU https://pubmed.ncbi.nlm.nih.gov/1652022 DM415DB DI DM415DB DM415DB DN 4-Amino-3-(5-chloro-thiophen-2-yl)-butyric acid DM415DB MI TTDCVZW DM415DB MN Gamma-aminobutyric acid B receptor (GABBR) DM415DB MT DTT DM415DB MA Inhibitor DM415DB RN 3-Thienyl- and 3-furylaminobutyric acids. Synthesis and binding GABAB receptor studies. J Med Chem. 1991 Aug;34(8):2557-60. DM415DB RU https://pubmed.ncbi.nlm.nih.gov/1652022 DMEDRAX DI DMEDRAX DMEDRAX DN 4-Amino-3-(5-methyl-thiophen-2-yl)-butyric acid DMEDRAX MI TTDCVZW DMEDRAX MN Gamma-aminobutyric acid B receptor (GABBR) DMEDRAX MT DTT DMEDRAX MA Inhibitor DMEDRAX RN 3-Thienyl- and 3-furylaminobutyric acids. Synthesis and binding GABAB receptor studies. J Med Chem. 1991 Aug;34(8):2557-60. DMEDRAX RU https://pubmed.ncbi.nlm.nih.gov/1652022 DMDCQAX DI DMDCQAX DMDCQAX DN 4-amino-3,5-dibromobenzenesulfonamide DMDCQAX MI TTUNARX DMDCQAX MN Carbonic anhydrase (CA) DMDCQAX MT DTT DMDCQAX MA Inhibitor DMDCQAX RN Carbonic anhydrase inhibitors: cloning, characterization, and inhibition studies of the cytosolic isozyme III with sulfonamides. Bioorg Med Chem. 2007 Dec 1;15(23):7229-36. DMDCQAX RU https://pubmed.ncbi.nlm.nih.gov/17826101 DM1IHCV DI DM1IHCV DM1IHCV DN 4-Amino-3-benzofuran-2-yl-butyric acid DM1IHCV MI TTDCVZW DM1IHCV MN Gamma-aminobutyric acid B receptor (GABBR) DM1IHCV MT DTT DM1IHCV MA Inhibitor DM1IHCV RN Synthesis and pharmacological evaluation of gamma-aminobutyric acid analogues. New ligand for GABAB sites. J Med Chem. 1987 Apr;30(4):743-6. DM1IHCV RU https://pubmed.ncbi.nlm.nih.gov/3031294 DMVUCZK DI DMVUCZK DMVUCZK DN 4-Amino-3-bromo-benzenesulfonamide DMVUCZK MI TTUNARX DMVUCZK MN Carbonic anhydrase (CA) DMVUCZK MT DTT DMVUCZK MA Inhibitor DMVUCZK RN Cloning, expression, post-translational modifications and inhibition studies on the latest mammalian carbonic anhydrase isoform, CA XV. J Med Chem. 2009 Feb 12;52(3):646-54. DMVUCZK RU https://pubmed.ncbi.nlm.nih.gov/19193158 DMVUCZK DI DMVUCZK DMVUCZK DN 4-Amino-3-bromo-benzenesulfonamide DMVUCZK MI TTHQPL7 DMVUCZK MN Carbonic anhydrase I (CA-I) DMVUCZK MT DTT DMVUCZK MA Inhibitor DMVUCZK RN Carbonic anhydrase inhibitors. Inhibition studies of a coral secretory isoform by sulfonamides. Bioorg Med Chem. 2009 Jul 15;17(14):5054-8. DMVUCZK RU https://pubmed.ncbi.nlm.nih.gov/19520577 DMVUCZK DI DMVUCZK DMVUCZK DN 4-Amino-3-bromo-benzenesulfonamide DMVUCZK MI TTANPDJ DMVUCZK MN Carbonic anhydrase II (CA-II) DMVUCZK MT DTT DMVUCZK MA Inhibitor DMVUCZK RN Carbonic anhydrase inhibitors. Characterization and inhibition studies of the most active beta-carbonic anhydrase from Mycobacterium tuberculosis, ... Bioorg Med Chem Lett. 2009 Dec 1;19(23):6649-54. DMVUCZK RU https://pubmed.ncbi.nlm.nih.gov/19846301 DMVUCZK DI DMVUCZK DMVUCZK DN 4-Amino-3-bromo-benzenesulfonamide DMVUCZK MI TTZHA0O DMVUCZK MN Carbonic anhydrase IV (CA-IV) DMVUCZK MT DTT DMVUCZK MA Inhibitor DMVUCZK RN Carbonic anhydrase inhibitors. Inhibition of the membrane-bound human and bovine isozymes IV with sulfonamides. Bioorg Med Chem Lett. 2005 Feb 15;15(4):1149-54. DMVUCZK RU https://pubmed.ncbi.nlm.nih.gov/15686931 DMVUCZK DI DMVUCZK DMVUCZK DN 4-Amino-3-bromo-benzenesulfonamide DMVUCZK MI TT2LVK8 DMVUCZK MN Carbonic anhydrase IX (CA-IX) DMVUCZK MT DTT DMVUCZK MA Inhibitor DMVUCZK RN Cloning, expression, post-translational modifications and inhibition studies on the latest mammalian carbonic anhydrase isoform, CA XV. J Med Chem. 2009 Feb 12;52(3):646-54. DMVUCZK RU https://pubmed.ncbi.nlm.nih.gov/19193158 DMVUCZK DI DMVUCZK DMVUCZK DN 4-Amino-3-bromo-benzenesulfonamide DMVUCZK MI TTCFSPE DMVUCZK MN Carbonic anhydrase VI (CA-VI) DMVUCZK MT DTT DMVUCZK MA Inhibitor DMVUCZK RN Cloning, expression, post-translational modifications and inhibition studies on the latest mammalian carbonic anhydrase isoform, CA XV. J Med Chem. 2009 Feb 12;52(3):646-54. DMVUCZK RU https://pubmed.ncbi.nlm.nih.gov/19193158 DMVUCZK DI DMVUCZK DMVUCZK DN 4-Amino-3-bromo-benzenesulfonamide DMVUCZK MI TTSYM0R DMVUCZK MN Carbonic anhydrase XII (CA-XII) DMVUCZK MT DTT DMVUCZK MA Inhibitor DMVUCZK RN Carbonic anhydrase inhibitors. Inhibition of the transmembrane isozyme XII with sulfonamides-a new target for the design of antitumor and antiglauc... Bioorg Med Chem Lett. 2005 Feb 15;15(4):963-9. DMVUCZK RU https://pubmed.ncbi.nlm.nih.gov/15686894 DMVUCZK DI DMVUCZK DMVUCZK DN 4-Amino-3-bromo-benzenesulfonamide DMVUCZK MI TTEYTKG DMVUCZK MN Carbonic anhydrase XIV (CA-XIV) DMVUCZK MT DTT DMVUCZK MA Inhibitor DMVUCZK RN Carbonic anhydrase inhibitors: inhibition of the transmembrane isozyme XIV with sulfonamides. Bioorg Med Chem Lett. 2005 Sep 1;15(17):3828-33. DMVUCZK RU https://pubmed.ncbi.nlm.nih.gov/16039848 DMERTQ4 DI DMERTQ4 DMERTQ4 DN 4-Amino-3-chloro-benzenesulfonamide DMERTQ4 MI TTUNARX DMERTQ4 MN Carbonic anhydrase (CA) DMERTQ4 MT DTT DMERTQ4 MA Inhibitor DMERTQ4 RN Cloning, expression, post-translational modifications and inhibition studies on the latest mammalian carbonic anhydrase isoform, CA XV. J Med Chem. 2009 Feb 12;52(3):646-54. DMERTQ4 RU https://pubmed.ncbi.nlm.nih.gov/19193158 DMERTQ4 DI DMERTQ4 DMERTQ4 DN 4-Amino-3-chloro-benzenesulfonamide DMERTQ4 MI TTHQPL7 DMERTQ4 MN Carbonic anhydrase I (CA-I) DMERTQ4 MT DTT DMERTQ4 MA Inhibitor DMERTQ4 RN Carbonic anhydrase inhibitors. Inhibition studies of a coral secretory isoform by sulfonamides. Bioorg Med Chem. 2009 Jul 15;17(14):5054-8. DMERTQ4 RU https://pubmed.ncbi.nlm.nih.gov/19520577 DMERTQ4 DI DMERTQ4 DMERTQ4 DN 4-Amino-3-chloro-benzenesulfonamide DMERTQ4 MI TTANPDJ DMERTQ4 MN Carbonic anhydrase II (CA-II) DMERTQ4 MT DTT DMERTQ4 MA Inhibitor DMERTQ4 RN Carbonic anhydrase inhibitors. Characterization and inhibition studies of the most active beta-carbonic anhydrase from Mycobacterium tuberculosis, ... Bioorg Med Chem Lett. 2009 Dec 1;19(23):6649-54. DMERTQ4 RU https://pubmed.ncbi.nlm.nih.gov/19846301 DMERTQ4 DI DMERTQ4 DMERTQ4 DN 4-Amino-3-chloro-benzenesulfonamide DMERTQ4 MI TTZHA0O DMERTQ4 MN Carbonic anhydrase IV (CA-IV) DMERTQ4 MT DTT DMERTQ4 MA Inhibitor DMERTQ4 RN Carbonic anhydrase inhibitors. Inhibition of the membrane-bound human and bovine isozymes IV with sulfonamides. Bioorg Med Chem Lett. 2005 Feb 15;15(4):1149-54. DMERTQ4 RU https://pubmed.ncbi.nlm.nih.gov/15686931 DMERTQ4 DI DMERTQ4 DMERTQ4 DN 4-Amino-3-chloro-benzenesulfonamide DMERTQ4 MI TT2LVK8 DMERTQ4 MN Carbonic anhydrase IX (CA-IX) DMERTQ4 MT DTT DMERTQ4 MA Inhibitor DMERTQ4 RN Cloning, expression, post-translational modifications and inhibition studies on the latest mammalian carbonic anhydrase isoform, CA XV. J Med Chem. 2009 Feb 12;52(3):646-54. DMERTQ4 RU https://pubmed.ncbi.nlm.nih.gov/19193158 DMERTQ4 DI DMERTQ4 DMERTQ4 DN 4-Amino-3-chloro-benzenesulfonamide DMERTQ4 MI TTCFSPE DMERTQ4 MN Carbonic anhydrase VI (CA-VI) DMERTQ4 MT DTT DMERTQ4 MA Inhibitor DMERTQ4 RN Cloning, expression, post-translational modifications and inhibition studies on the latest mammalian carbonic anhydrase isoform, CA XV. J Med Chem. 2009 Feb 12;52(3):646-54. DMERTQ4 RU https://pubmed.ncbi.nlm.nih.gov/19193158 DMERTQ4 DI DMERTQ4 DMERTQ4 DN 4-Amino-3-chloro-benzenesulfonamide DMERTQ4 MI TTSYM0R DMERTQ4 MN Carbonic anhydrase XII (CA-XII) DMERTQ4 MT DTT DMERTQ4 MA Inhibitor DMERTQ4 RN Carbonic anhydrase inhibitors. Inhibition of the transmembrane isozyme XII with sulfonamides-a new target for the design of antitumor and antiglauc... Bioorg Med Chem Lett. 2005 Feb 15;15(4):963-9. DMERTQ4 RU https://pubmed.ncbi.nlm.nih.gov/15686894 DMERTQ4 DI DMERTQ4 DMERTQ4 DN 4-Amino-3-chloro-benzenesulfonamide DMERTQ4 MI TTEYTKG DMERTQ4 MN Carbonic anhydrase XIV (CA-XIV) DMERTQ4 MT DTT DMERTQ4 MA Inhibitor DMERTQ4 RN Carbonic anhydrase inhibitors: inhibition of the transmembrane isozyme XIV with sulfonamides. Bioorg Med Chem Lett. 2005 Sep 1;15(17):3828-33. DMERTQ4 RU https://pubmed.ncbi.nlm.nih.gov/16039848 DMR9M6H DI DMR9M6H DMR9M6H DN 4-amino-3-fluoro-5-iodobenzenesulfonamide DMR9M6H MI TTUNARX DMR9M6H MN Carbonic anhydrase (CA) DMR9M6H MT DTT DMR9M6H MA Inhibitor DMR9M6H RN Carbonic anhydrase inhibitors: cloning, characterization, and inhibition studies of the cytosolic isozyme III with sulfonamides. Bioorg Med Chem. 2007 Dec 1;15(23):7229-36. DMR9M6H RU https://pubmed.ncbi.nlm.nih.gov/17826101 DMIQ3VR DI DMIQ3VR DMIQ3VR DN 4-Amino-3-fluoro-benzenesulfonamide DMIQ3VR MI TTUNARX DMIQ3VR MN Carbonic anhydrase (CA) DMIQ3VR MT DTT DMIQ3VR MA Inhibitor DMIQ3VR RN Cloning, expression, post-translational modifications and inhibition studies on the latest mammalian carbonic anhydrase isoform, CA XV. J Med Chem. 2009 Feb 12;52(3):646-54. DMIQ3VR RU https://pubmed.ncbi.nlm.nih.gov/19193158 DMIQ3VR DI DMIQ3VR DMIQ3VR DN 4-Amino-3-fluoro-benzenesulfonamide DMIQ3VR MI TTHQPL7 DMIQ3VR MN Carbonic anhydrase I (CA-I) DMIQ3VR MT DTT DMIQ3VR MA Inhibitor DMIQ3VR RN Mutation of Phe91 to Asn in human carbonic anhydrase I unexpectedly enhanced both catalytic activity and affinity for sulfonamide inhibitors. Bioorg Med Chem. 2010 Aug 1;18(15):5498-503. DMIQ3VR RU https://pubmed.ncbi.nlm.nih.gov/20624682 DMIQ3VR DI DMIQ3VR DMIQ3VR DN 4-Amino-3-fluoro-benzenesulfonamide DMIQ3VR MI TTANPDJ DMIQ3VR MN Carbonic anhydrase II (CA-II) DMIQ3VR MT DTT DMIQ3VR MA Inhibitor DMIQ3VR RN Mutation of Phe91 to Asn in human carbonic anhydrase I unexpectedly enhanced both catalytic activity and affinity for sulfonamide inhibitors. Bioorg Med Chem. 2010 Aug 1;18(15):5498-503. DMIQ3VR RU https://pubmed.ncbi.nlm.nih.gov/20624682 DMIQ3VR DI DMIQ3VR DMIQ3VR DN 4-Amino-3-fluoro-benzenesulfonamide DMIQ3VR MI TTZHA0O DMIQ3VR MN Carbonic anhydrase IV (CA-IV) DMIQ3VR MT DTT DMIQ3VR MA Inhibitor DMIQ3VR RN Carbonic anhydrase inhibitors. Inhibition of the membrane-bound human and bovine isozymes IV with sulfonamides. Bioorg Med Chem Lett. 2005 Feb 15;15(4):1149-54. DMIQ3VR RU https://pubmed.ncbi.nlm.nih.gov/15686931 DMIQ3VR DI DMIQ3VR DMIQ3VR DN 4-Amino-3-fluoro-benzenesulfonamide DMIQ3VR MI TT2LVK8 DMIQ3VR MN Carbonic anhydrase IX (CA-IX) DMIQ3VR MT DTT DMIQ3VR MA Inhibitor DMIQ3VR RN Cloning, expression, post-translational modifications and inhibition studies on the latest mammalian carbonic anhydrase isoform, CA XV. J Med Chem. 2009 Feb 12;52(3):646-54. DMIQ3VR RU https://pubmed.ncbi.nlm.nih.gov/19193158 DMIQ3VR DI DMIQ3VR DMIQ3VR DN 4-Amino-3-fluoro-benzenesulfonamide DMIQ3VR MI TTCFSPE DMIQ3VR MN Carbonic anhydrase VI (CA-VI) DMIQ3VR MT DTT DMIQ3VR MA Inhibitor DMIQ3VR RN Cloning, expression, post-translational modifications and inhibition studies on the latest mammalian carbonic anhydrase isoform, CA XV. J Med Chem. 2009 Feb 12;52(3):646-54. DMIQ3VR RU https://pubmed.ncbi.nlm.nih.gov/19193158 DMIQ3VR DI DMIQ3VR DMIQ3VR DN 4-Amino-3-fluoro-benzenesulfonamide DMIQ3VR MI TTSYM0R DMIQ3VR MN Carbonic anhydrase XII (CA-XII) DMIQ3VR MT DTT DMIQ3VR MA Inhibitor DMIQ3VR RN Carbonic anhydrase inhibitors. Inhibition of the transmembrane isozyme XII with sulfonamides-a new target for the design of antitumor and antiglauc... Bioorg Med Chem Lett. 2005 Feb 15;15(4):963-9. DMIQ3VR RU https://pubmed.ncbi.nlm.nih.gov/15686894 DMIQ3VR DI DMIQ3VR DMIQ3VR DN 4-Amino-3-fluoro-benzenesulfonamide DMIQ3VR MI TTEYTKG DMIQ3VR MN Carbonic anhydrase XIV (CA-XIV) DMIQ3VR MT DTT DMIQ3VR MA Inhibitor DMIQ3VR RN Carbonic anhydrase inhibitors: inhibition of the transmembrane isozyme XIV with sulfonamides. Bioorg Med Chem Lett. 2005 Sep 1;15(17):3828-33. DMIQ3VR RU https://pubmed.ncbi.nlm.nih.gov/16039848 DMPY8D3 DI DMPY8D3 DMPY8D3 DN 4-Amino-3-hydroxy-butyric acid DMPY8D3 MI TTNJYV2 DMPY8D3 MN Gamma-aminobutyric acid receptor (GAR) DMPY8D3 MT DTT DMPY8D3 MA Inhibitor DMPY8D3 RN GABA agonists. Resolution, absolute stereochemistry, and enantioselectivity of (S)-(+)- and (R)-(-)-dihydromuscimol. J Med Chem. 1985 Nov;28(11):1612-7. DMPY8D3 RU https://pubmed.ncbi.nlm.nih.gov/2999396 DMCOYHR DI DMCOYHR DMCOYHR DN 4-Amino-3-iodo-benzenesulfonamide DMCOYHR MI TTUNARX DMCOYHR MN Carbonic anhydrase (CA) DMCOYHR MT DTT DMCOYHR MA Inhibitor DMCOYHR RN Cloning, expression, post-translational modifications and inhibition studies on the latest mammalian carbonic anhydrase isoform, CA XV. J Med Chem. 2009 Feb 12;52(3):646-54. DMCOYHR RU https://pubmed.ncbi.nlm.nih.gov/19193158 DMCOYHR DI DMCOYHR DMCOYHR DN 4-Amino-3-iodo-benzenesulfonamide DMCOYHR MI TTHQPL7 DMCOYHR MN Carbonic anhydrase I (CA-I) DMCOYHR MT DTT DMCOYHR MA Inhibitor DMCOYHR RN Carbonic anhydrase inhibitors. Inhibition studies of a coral secretory isoform by sulfonamides. Bioorg Med Chem. 2009 Jul 15;17(14):5054-8. DMCOYHR RU https://pubmed.ncbi.nlm.nih.gov/19520577 DMCOYHR DI DMCOYHR DMCOYHR DN 4-Amino-3-iodo-benzenesulfonamide DMCOYHR MI TTANPDJ DMCOYHR MN Carbonic anhydrase II (CA-II) DMCOYHR MT DTT DMCOYHR MA Inhibitor DMCOYHR RN Carbonic anhydrase inhibitors. Characterization and inhibition studies of the most active beta-carbonic anhydrase from Mycobacterium tuberculosis, ... Bioorg Med Chem Lett. 2009 Dec 1;19(23):6649-54. DMCOYHR RU https://pubmed.ncbi.nlm.nih.gov/19846301 DMCOYHR DI DMCOYHR DMCOYHR DN 4-Amino-3-iodo-benzenesulfonamide DMCOYHR MI TTZHA0O DMCOYHR MN Carbonic anhydrase IV (CA-IV) DMCOYHR MT DTT DMCOYHR MA Inhibitor DMCOYHR RN Carbonic anhydrase inhibitors. Inhibition of the membrane-bound human and bovine isozymes IV with sulfonamides. Bioorg Med Chem Lett. 2005 Feb 15;15(4):1149-54. DMCOYHR RU https://pubmed.ncbi.nlm.nih.gov/15686931 DMCOYHR DI DMCOYHR DMCOYHR DN 4-Amino-3-iodo-benzenesulfonamide DMCOYHR MI TT2LVK8 DMCOYHR MN Carbonic anhydrase IX (CA-IX) DMCOYHR MT DTT DMCOYHR MA Inhibitor DMCOYHR RN Cloning, expression, post-translational modifications and inhibition studies on the latest mammalian carbonic anhydrase isoform, CA XV. J Med Chem. 2009 Feb 12;52(3):646-54. DMCOYHR RU https://pubmed.ncbi.nlm.nih.gov/19193158 DMCOYHR DI DMCOYHR DMCOYHR DN 4-Amino-3-iodo-benzenesulfonamide DMCOYHR MI TTCFSPE DMCOYHR MN Carbonic anhydrase VI (CA-VI) DMCOYHR MT DTT DMCOYHR MA Inhibitor DMCOYHR RN Cloning, expression, post-translational modifications and inhibition studies on the latest mammalian carbonic anhydrase isoform, CA XV. J Med Chem. 2009 Feb 12;52(3):646-54. DMCOYHR RU https://pubmed.ncbi.nlm.nih.gov/19193158 DMCOYHR DI DMCOYHR DMCOYHR DN 4-Amino-3-iodo-benzenesulfonamide DMCOYHR MI TTSYM0R DMCOYHR MN Carbonic anhydrase XII (CA-XII) DMCOYHR MT DTT DMCOYHR MA Inhibitor DMCOYHR RN Carbonic anhydrase inhibitors. Inhibition of the transmembrane isozyme XII with sulfonamides-a new target for the design of antitumor and antiglauc... Bioorg Med Chem Lett. 2005 Feb 15;15(4):963-9. DMCOYHR RU https://pubmed.ncbi.nlm.nih.gov/15686894 DMCOYHR DI DMCOYHR DMCOYHR DN 4-Amino-3-iodo-benzenesulfonamide DMCOYHR MI TTEYTKG DMCOYHR MN Carbonic anhydrase XIV (CA-XIV) DMCOYHR MT DTT DMCOYHR MA Inhibitor DMCOYHR RN Carbonic anhydrase inhibitors: inhibition of the transmembrane isozyme XIV with sulfonamides. Bioorg Med Chem Lett. 2005 Sep 1;15(17):3828-33. DMCOYHR RU https://pubmed.ncbi.nlm.nih.gov/16039848 DMZJS2E DI DMZJS2E DMZJS2E DN 4-Amino-3-thiophen-2-yl-butyric acid DMZJS2E MI TTDCVZW DMZJS2E MN Gamma-aminobutyric acid B receptor (GABBR) DMZJS2E MT DTT DMZJS2E MA Inhibitor DMZJS2E RN 3-Thienyl- and 3-furylaminobutyric acids. Synthesis and binding GABAB receptor studies. J Med Chem. 1991 Aug;34(8):2557-60. DMZJS2E RU https://pubmed.ncbi.nlm.nih.gov/1652022 DMQ6EBR DI DMQ6EBR DMQ6EBR DN 4'-amino-4-(1,1-dimethyl-heptyl)-biphenyl-2-ol DMQ6EBR MI TT6OEDT DMQ6EBR MN Cannabinoid receptor 1 (CB1) DMQ6EBR MT DTT DMQ6EBR MA Inhibitor DMQ6EBR RN Biaryl cannabinoid mimetics--synthesis and structure-activity relationship. Bioorg Med Chem Lett. 2007 Jul 1;17(13):3652-6. DMQ6EBR RU https://pubmed.ncbi.nlm.nih.gov/17507224 DMQ6EBR DI DMQ6EBR DMQ6EBR DN 4'-amino-4-(1,1-dimethyl-heptyl)-biphenyl-2-ol DMQ6EBR MI TTMSFAW DMQ6EBR MN Cannabinoid receptor 2 (CB2) DMQ6EBR MT DTT DMQ6EBR MA Inhibitor DMQ6EBR RN Biaryl cannabinoid mimetics--synthesis and structure-activity relationship. Bioorg Med Chem Lett. 2007 Jul 1;17(13):3652-6. DMQ6EBR RU https://pubmed.ncbi.nlm.nih.gov/17507224 DM9S5V0 DI DM9S5V0 DM9S5V0 DN 4'-Amino-4-hydroxychalcone DM9S5V0 MI TTULVH8 DM9S5V0 MN Tyrosinase (TYR) DM9S5V0 MT DTT DM9S5V0 MA Inhibitor DM9S5V0 RN Evaluation of anti-pigmentary effect of synthetic sulfonylamino chalcone. Eur J Med Chem. 2010 May;45(5):2010-7. DM9S5V0 RU https://pubmed.ncbi.nlm.nih.gov/20149498 DMZRM0Q DI DMZRM0Q DMZRM0Q DN 4-amino-6-(4-octylphenyl)hexanoic acid DMZRM0Q MI TT9JZCK DMZRM0Q MN Sphingosine-1-phosphate receptor 1 (S1PR1) DMZRM0Q MT DTT DMZRM0Q MA Inhibitor DMZRM0Q RN S1P receptor mediated activity of FTY720 phosphate mimics. Bioorg Med Chem Lett. 2010 Mar 1;20(5):1485-7. DMZRM0Q RU https://pubmed.ncbi.nlm.nih.gov/20153186 DMIWGZS DI DMIWGZS DMIWGZS DN 4-amino-6-chlorobenzene-1,3-disulfonamide DMIWGZS MI TTUNARX DMIWGZS MN Carbonic anhydrase (CA) DMIWGZS MT DTT DMIWGZS MA Inhibitor DMIWGZS RN Cloning, expression, post-translational modifications and inhibition studies on the latest mammalian carbonic anhydrase isoform, CA XV. J Med Chem. 2009 Feb 12;52(3):646-54. DMIWGZS RU https://pubmed.ncbi.nlm.nih.gov/19193158 DMIWGZS DI DMIWGZS DMIWGZS DN 4-amino-6-chlorobenzene-1,3-disulfonamide DMIWGZS MI TTHQPL7 DMIWGZS MN Carbonic anhydrase I (CA-I) DMIWGZS MT DTT DMIWGZS MA Inhibitor DMIWGZS RN Mutation of Phe91 to Asn in human carbonic anhydrase I unexpectedly enhanced both catalytic activity and affinity for sulfonamide inhibitors. Bioorg Med Chem. 2010 Aug 1;18(15):5498-503. DMIWGZS RU https://pubmed.ncbi.nlm.nih.gov/20624682 DMIWGZS DI DMIWGZS DMIWGZS DN 4-amino-6-chlorobenzene-1,3-disulfonamide DMIWGZS MI TTANPDJ DMIWGZS MN Carbonic anhydrase II (CA-II) DMIWGZS MT DTT DMIWGZS MA Inhibitor DMIWGZS RN Mutation of Phe91 to Asn in human carbonic anhydrase I unexpectedly enhanced both catalytic activity and affinity for sulfonamide inhibitors. Bioorg Med Chem. 2010 Aug 1;18(15):5498-503. DMIWGZS RU https://pubmed.ncbi.nlm.nih.gov/20624682 DMIWGZS DI DMIWGZS DMIWGZS DN 4-amino-6-chlorobenzene-1,3-disulfonamide DMIWGZS MI TT2LVK8 DMIWGZS MN Carbonic anhydrase IX (CA-IX) DMIWGZS MT DTT DMIWGZS MA Inhibitor DMIWGZS RN Cloning, expression, post-translational modifications and inhibition studies on the latest mammalian carbonic anhydrase isoform, CA XV. J Med Chem. 2009 Feb 12;52(3):646-54. DMIWGZS RU https://pubmed.ncbi.nlm.nih.gov/19193158 DMIWGZS DI DMIWGZS DMIWGZS DN 4-amino-6-chlorobenzene-1,3-disulfonamide DMIWGZS MI TTCFSPE DMIWGZS MN Carbonic anhydrase VI (CA-VI) DMIWGZS MT DTT DMIWGZS MA Inhibitor DMIWGZS RN Cloning, expression, post-translational modifications and inhibition studies on the latest mammalian carbonic anhydrase isoform, CA XV. J Med Chem. 2009 Feb 12;52(3):646-54. DMIWGZS RU https://pubmed.ncbi.nlm.nih.gov/19193158 DMP2GN7 DI DMP2GN7 DMP2GN7 DN 4-aminobenzoic acid hydrazide DMP2GN7 MI TTVCZPI DMP2GN7 MN Myeloperoxidase (MPO) DMP2GN7 MT DTT DMP2GN7 MA Inhibitor DMP2GN7 RN Myeloperoxidase expression as a potential determinant of parthenolide-induced apoptosis in leukemia bulk and leukemia stem cells. J Pharmacol Exp Ther. 2010 Nov;335(2):389-400. DMP2GN7 RU https://pubmed.ncbi.nlm.nih.gov/20699435 DMHDB70 DI DMHDB70 DMHDB70 DN 4-amino-biphenyl-3-carboxylic acid amide DMHDB70 MI TTJ3E9X DMHDB70 MN Inhibitor of nuclear factor kappa-B kinase beta (IKKB) DMHDB70 MT DTT DMHDB70 MA Inhibitor DMHDB70 RN Evolution of the thienopyridine class of inhibitors of IkappaB kinase-beta: part I: hit-to-lead strategies. J Med Chem. 2006 May 18;49(10):2898-908. DMHDB70 RU https://pubmed.ncbi.nlm.nih.gov/16686533 DM6PQ5V DI DM6PQ5V DM6PQ5V DN 4-amino-N-(2-chlorophenyl)benzenesulfonamide DM6PQ5V MI TT8NGED DM6PQ5V MN Prostaglandin G/H synthase 1 (COX-1) DM6PQ5V MT DTT DM6PQ5V MA Inhibitor DM6PQ5V RN Analgesic agents without gastric damage: design and synthesis of structurally simple benzenesulfonanilide-type cyclooxygenase-1-selective inhibitors. Bioorg Med Chem. 2007 Jan 15;15(2):1014-21. DM6PQ5V RU https://pubmed.ncbi.nlm.nih.gov/17079150 DMCUSD4 DI DMCUSD4 DMCUSD4 DN 4-amino-N-(4-chlorophenyl)benzenesulfonamide DMCUSD4 MI TT8NGED DMCUSD4 MN Prostaglandin G/H synthase 1 (COX-1) DMCUSD4 MT DTT DMCUSD4 MA Inhibitor DMCUSD4 RN Analgesic agents without gastric damage: design and synthesis of structurally simple benzenesulfonanilide-type cyclooxygenase-1-selective inhibitors. Bioorg Med Chem. 2007 Jan 15;15(2):1014-21. DMCUSD4 RU https://pubmed.ncbi.nlm.nih.gov/17079150 DMCUSD4 DI DMCUSD4 DMCUSD4 DN 4-amino-N-(4-chlorophenyl)benzenesulfonamide DMCUSD4 MI TTVKILB DMCUSD4 MN Prostaglandin G/H synthase 2 (COX-2) DMCUSD4 MT DTT DMCUSD4 MA Inhibitor DMCUSD4 RN Analgesic agents without gastric damage: design and synthesis of structurally simple benzenesulfonanilide-type cyclooxygenase-1-selective inhibitors. Bioorg Med Chem. 2007 Jan 15;15(2):1014-21. DMCUSD4 RU https://pubmed.ncbi.nlm.nih.gov/17079150 DMN19QP DI DMN19QP DMN19QP DN 4-amino-N-(4-iodophenyl)benzenesulfonamide DMN19QP MI TTVKILB DMN19QP MN Prostaglandin G/H synthase 2 (COX-2) DMN19QP MT DTT DMN19QP MA Inhibitor DMN19QP RN Analgesic agents without gastric damage: design and synthesis of structurally simple benzenesulfonanilide-type cyclooxygenase-1-selective inhibitors. Bioorg Med Chem. 2007 Jan 15;15(2):1014-21. DMN19QP RU https://pubmed.ncbi.nlm.nih.gov/17079150 DMJZNX6 DI DMJZNX6 DMJZNX6 DN 4-amino-N-(4-sulfamoylbenzyl)benzenesulfonamide DMJZNX6 MI TTUNARX DMJZNX6 MN Carbonic anhydrase (CA) DMJZNX6 MT DTT DMJZNX6 MA Inhibitor DMJZNX6 RN Cloning, expression, post-translational modifications and inhibition studies on the latest mammalian carbonic anhydrase isoform, CA XV. J Med Chem. 2009 Feb 12;52(3):646-54. DMJZNX6 RU https://pubmed.ncbi.nlm.nih.gov/19193158 DMJZNX6 DI DMJZNX6 DMJZNX6 DN 4-amino-N-(4-sulfamoylbenzyl)benzenesulfonamide DMJZNX6 MI TTHQPL7 DMJZNX6 MN Carbonic anhydrase I (CA-I) DMJZNX6 MT DTT DMJZNX6 MA Inhibitor DMJZNX6 RN Carbonic anhydrase inhibitors. Inhibition studies of a coral secretory isoform by sulfonamides. Bioorg Med Chem. 2009 Jul 15;17(14):5054-8. DMJZNX6 RU https://pubmed.ncbi.nlm.nih.gov/19520577 DMJZNX6 DI DMJZNX6 DMJZNX6 DN 4-amino-N-(4-sulfamoylbenzyl)benzenesulfonamide DMJZNX6 MI TTANPDJ DMJZNX6 MN Carbonic anhydrase II (CA-II) DMJZNX6 MT DTT DMJZNX6 MA Inhibitor DMJZNX6 RN Carbonic anhydrase inhibitors. Characterization and inhibition studies of the most active beta-carbonic anhydrase from Mycobacterium tuberculosis, ... Bioorg Med Chem Lett. 2009 Dec 1;19(23):6649-54. DMJZNX6 RU https://pubmed.ncbi.nlm.nih.gov/19846301 DMJZNX6 DI DMJZNX6 DMJZNX6 DN 4-amino-N-(4-sulfamoylbenzyl)benzenesulfonamide DMJZNX6 MI TT2LVK8 DMJZNX6 MN Carbonic anhydrase IX (CA-IX) DMJZNX6 MT DTT DMJZNX6 MA Inhibitor DMJZNX6 RN Cloning, expression, post-translational modifications and inhibition studies on the latest mammalian carbonic anhydrase isoform, CA XV. J Med Chem. 2009 Feb 12;52(3):646-54. DMJZNX6 RU https://pubmed.ncbi.nlm.nih.gov/19193158 DMJZNX6 DI DMJZNX6 DMJZNX6 DN 4-amino-N-(4-sulfamoylbenzyl)benzenesulfonamide DMJZNX6 MI TTCFSPE DMJZNX6 MN Carbonic anhydrase VI (CA-VI) DMJZNX6 MT DTT DMJZNX6 MA Inhibitor DMJZNX6 RN Cloning, expression, post-translational modifications and inhibition studies on the latest mammalian carbonic anhydrase isoform, CA XV. J Med Chem. 2009 Feb 12;52(3):646-54. DMJZNX6 RU https://pubmed.ncbi.nlm.nih.gov/19193158 DMDX0VP DI DMDX0VP DMDX0VP DN 4-amino-N-[4-(benzyloxy)phenyl]butanamide DMDX0VP MI TTXZEAJ DMDX0VP MN Leukotriene A-4 hydrolase (LTA4H) DMDX0VP MT DTT DMDX0VP MA Inhibitor DMDX0VP RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DMDX0VP RU https://pubmed.ncbi.nlm.nih.gov/10592235 DMIG82P DI DMIG82P DMIG82P DN 4-aminonaphthalen-1-ol DMIG82P MI TTZJYKH DMIG82P MN Indoleamine 2,3-dioxygenase 1 (IDO1) DMIG82P MT DTT DMIG82P MA Inhibitor DMIG82P RN Rational design of indoleamine 2,3-dioxygenase inhibitors. J Med Chem. 2010 Feb 11;53(3):1172-89. DMIG82P RU https://pubmed.ncbi.nlm.nih.gov/20055453 DMLW651 DI DMLW651 DMLW651 DN 4-amino-N-p-tolylbenzenesulfonamide DMLW651 MI TT8NGED DMLW651 MN Prostaglandin G/H synthase 1 (COX-1) DMLW651 MT DTT DMLW651 MA Inhibitor DMLW651 RN Analgesic agents without gastric damage: design and synthesis of structurally simple benzenesulfonanilide-type cyclooxygenase-1-selective inhibitors. Bioorg Med Chem. 2007 Jan 15;15(2):1014-21. DMLW651 RU https://pubmed.ncbi.nlm.nih.gov/17079150 DMYC1T6 DI DMYC1T6 DMYC1T6 DN 4-AMINOPHENOL DMYC1T6 MI TTUNARX DMYC1T6 MN Carbonic anhydrase (CA) DMYC1T6 MT DTT DMYC1T6 MA Inhibitor DMYC1T6 RN Carbonic anhydrase inhibitors: inhibition of mammalian isoforms I-XIV with a series of substituted phenols including paracetamol and salicylic acid. Bioorg Med Chem. 2008 Aug 1;16(15):7424-8. DMYC1T6 RU https://pubmed.ncbi.nlm.nih.gov/18579385 DMYC1T6 DI DMYC1T6 DMYC1T6 DN 4-AMINOPHENOL DMYC1T6 MI TTEYTKG DMYC1T6 MN Carbonic anhydrase XIV (CA-XIV) DMYC1T6 MT DTT DMYC1T6 MA Inhibitor DMYC1T6 RN Carbonic anhydrase inhibitors: inhibition of mammalian isoforms I-XIV with a series of substituted phenols including paracetamol and salicylic acid. Bioorg Med Chem. 2008 Aug 1;16(15):7424-8. DMYC1T6 RU https://pubmed.ncbi.nlm.nih.gov/18579385 DMSE8NU DI DMSE8NU DMSE8NU DN 4-ANDROSTENE-3-17-DIONE DMSE8NU MI TTSZLWK DMSE8NU MN Aromatase (CYP19A1) DMSE8NU MT DTT DMSE8NU MA Inhibitor DMSE8NU RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DMSE8NU RU https://pubmed.ncbi.nlm.nih.gov/10592235 DMSE8NU DI DMSE8NU DMSE8NU DN 4-ANDROSTENE-3-17-DIONE DMSE8NU MI TT5ZWB6 DMSE8NU MN Dihydrodiol dehydrogenase type I (AKR1C3) DMSE8NU MT DTT DMSE8NU MA Inhibitor DMSE8NU RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMSE8NU RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMSE8NU DI DMSE8NU DMSE8NU DN 4-ANDROSTENE-3-17-DIONE DMSE8NU MI TTIWB6L DMSE8NU MN Estradiol 17 beta-dehydrogenase 1 (17-beta-HSD1) DMSE8NU MT DTT DMSE8NU MA Inhibitor DMSE8NU RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMSE8NU RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMSE8NU DI DMSE8NU DMSE8NU DN 4-ANDROSTENE-3-17-DIONE DMSE8NU MI TTZT9R2 DMSE8NU MN Hydroxysteroid dehydrogenase 3-beta (HSD3B) DMSE8NU MT DTT DMSE8NU MA Agonist DMSE8NU RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMSE8NU RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMSE8NU DI DMSE8NU DMSE8NU DN 4-ANDROSTENE-3-17-DIONE DMSE8NU MI DEX8J7E DMSE8NU MN Testicular 17-beta-hydroxysteroid dehydrogenase (HSD17B3) DMSE8NU MT DME DMSE8NU MA Metabolism DMSE8NU RN 17beta-hydroxysteroid dehydrogenase-3 deficiency: a rare endocrine cause of male-to-female sex reversal. Gynecol Endocrinol. 2006 Sep;22(9):488-94. DMSE8NU RU https://www.ncbi.nlm.nih.gov/pubmed/?term=17071532 DM1UXHE DI DM1UXHE DM1UXHE DN 4-APPES DM1UXHE MI TTXJ47W DM1UXHE MN Metabotropic glutamate receptor 2 (mGluR2) DM1UXHE MT DTT DM1UXHE MA Modulator (allosteric modulator) DM1UXHE RN Metabotropic glutamate 2 receptor potentiators: receptor modulation, frequency-dependent synaptic activity, and efficacy in preclinical anxiety and... Psychopharmacology (Berl). 2005 Apr;179(1):271-83. DM1UXHE RU https://pubmed.ncbi.nlm.nih.gov/15717213 DM3UE42 DI DM3UE42 DM3UE42 DN 4-arylphthalazin-1(2H)-3,4-Di-F DM3UE42 MI TTX4RTB DM3UE42 MN Melanin-concentrating hormone receptor 1 (MCHR1) DM3UE42 MT DTT DM3UE42 MA Antagonist DM3UE42 RN 4-arylphthalazin-1(2H)-one derivatives as potent antagonists of the melanin concentrating hormone receptor 1 (MCH-R1). Bioorg Med Chem Lett. 2012 Jan 1;22(1):427-30. DM3UE42 RU https://pubmed.ncbi.nlm.nih.gov/22137790 DM7EQ06 DI DM7EQ06 DM7EQ06 DN 4-azidobenzenesulfonamide DM7EQ06 MI TTUNARX DM7EQ06 MN Carbonic anhydrase (CA) DM7EQ06 MT DTT DM7EQ06 MA Inhibitor DM7EQ06 RN Inhibition of human mitochondrial carbonic anhydrases VA and VB with para-(4-phenyltriazole-1-yl)-benzenesulfonamide derivatives. Bioorg Med Chem Lett. 2008 Aug 15;18(16):4624-7. DM7EQ06 RU https://pubmed.ncbi.nlm.nih.gov/18644716 DM7EQ06 DI DM7EQ06 DM7EQ06 DN 4-azidobenzenesulfonamide DM7EQ06 MI TTHQPL7 DM7EQ06 MN Carbonic anhydrase I (CA-I) DM7EQ06 MT DTT DM7EQ06 MA Inhibitor DM7EQ06 RN Inhibition of human mitochondrial carbonic anhydrases VA and VB with para-(4-phenyltriazole-1-yl)-benzenesulfonamide derivatives. Bioorg Med Chem Lett. 2008 Aug 15;18(16):4624-7. DM7EQ06 RU https://pubmed.ncbi.nlm.nih.gov/18644716 DM7EQ06 DI DM7EQ06 DM7EQ06 DN 4-azidobenzenesulfonamide DM7EQ06 MI TTANPDJ DM7EQ06 MN Carbonic anhydrase II (CA-II) DM7EQ06 MT DTT DM7EQ06 MA Inhibitor DM7EQ06 RN Inhibition of human mitochondrial carbonic anhydrases VA and VB with para-(4-phenyltriazole-1-yl)-benzenesulfonamide derivatives. Bioorg Med Chem Lett. 2008 Aug 15;18(16):4624-7. DM7EQ06 RU https://pubmed.ncbi.nlm.nih.gov/18644716 DM7EQ06 DI DM7EQ06 DM7EQ06 DN 4-azidobenzenesulfonamide DM7EQ06 MI TT2LVK8 DM7EQ06 MN Carbonic anhydrase IX (CA-IX) DM7EQ06 MT DTT DM7EQ06 MA Inhibitor DM7EQ06 RN Inhibition of carbonic anhydrase isozymes with benzene sulfonamides incorporating thio, sulfinyl and sulfonyl glycoside moieties. Bioorg Med Chem Lett. 2009 Apr 15;19(8):2273-6. DM7EQ06 RU https://pubmed.ncbi.nlm.nih.gov/19286378 DMACRHS DI DMACRHS DMACRHS DN 4-Benzenesulfonyl-1-(3-phenyl-propyl)-piperidine DMACRHS MI TTQ6VDM DMACRHS MN Voltage-gated potassium channel Kv11.1 (KCNH2) DMACRHS MT DTT DMACRHS MA Inhibitor DMACRHS RN 4-(Phenylsulfonyl)piperidines: novel, selective, and bioavailable 5-HT(2A) receptor antagonists. J Med Chem. 2002 Jan 17;45(2):492-503. DMACRHS RU https://pubmed.ncbi.nlm.nih.gov/11784153 DMCKT3Q DI DMCKT3Q DMCKT3Q DN 4-Benzenesulfonyl-1-phenethyl-piperidine DMCKT3Q MI TTQ6VDM DMCKT3Q MN Voltage-gated potassium channel Kv11.1 (KCNH2) DMCKT3Q MT DTT DMCKT3Q MA Inhibitor DMCKT3Q RN 4-(Phenylsulfonyl)piperidines: novel, selective, and bioavailable 5-HT(2A) receptor antagonists. J Med Chem. 2002 Jan 17;45(2):492-503. DMCKT3Q RU https://pubmed.ncbi.nlm.nih.gov/11784153 DMC7HKA DI DMC7HKA DMC7HKA DN 4-Benzenesulfonylamino-benzenesulfonamide DMC7HKA MI TTHQPL7 DMC7HKA MN Carbonic anhydrase I (CA-I) DMC7HKA MT DTT DMC7HKA MA Inhibitor DMC7HKA RN Carbonic anhydrase inhibitors: inhibition of the tumor-associated isozymes IX and XII with a library of aromatic and heteroaromatic sulfonamides. Bioorg Med Chem Lett. 2005 Nov 1;15(21):4862-6. DMC7HKA RU https://pubmed.ncbi.nlm.nih.gov/16168653 DMC7HKA DI DMC7HKA DMC7HKA DN 4-Benzenesulfonylamino-benzenesulfonamide DMC7HKA MI TTANPDJ DMC7HKA MN Carbonic anhydrase II (CA-II) DMC7HKA MT DTT DMC7HKA MA Inhibitor DMC7HKA RN Carbonic anhydrase inhibitors: inhibition of the tumor-associated isozymes IX and XII with a library of aromatic and heteroaromatic sulfonamides. Bioorg Med Chem Lett. 2005 Nov 1;15(21):4862-6. DMC7HKA RU https://pubmed.ncbi.nlm.nih.gov/16168653 DMC7HKA DI DMC7HKA DMC7HKA DN 4-Benzenesulfonylamino-benzenesulfonamide DMC7HKA MI TT2LVK8 DMC7HKA MN Carbonic anhydrase IX (CA-IX) DMC7HKA MT DTT DMC7HKA MA Inhibitor DMC7HKA RN Carbonic anhydrase inhibitors: inhibition of the tumor-associated isozymes IX and XII with a library of aromatic and heteroaromatic sulfonamides. Bioorg Med Chem Lett. 2005 Nov 1;15(21):4862-6. DMC7HKA RU https://pubmed.ncbi.nlm.nih.gov/16168653 DMC7HKA DI DMC7HKA DMC7HKA DN 4-Benzenesulfonylamino-benzenesulfonamide DMC7HKA MI TTSYM0R DMC7HKA MN Carbonic anhydrase XII (CA-XII) DMC7HKA MT DTT DMC7HKA MA Inhibitor DMC7HKA RN Carbonic anhydrase inhibitors: inhibition of the tumor-associated isozymes IX and XII with a library of aromatic and heteroaromatic sulfonamides. Bioorg Med Chem Lett. 2005 Nov 1;15(21):4862-6. DMC7HKA RU https://pubmed.ncbi.nlm.nih.gov/16168653 DMM6UPD DI DMM6UPD DMM6UPD DN 4-Benzenesulfonylamino-N-hydroxy-benzamide DMM6UPD MI TT6R7JZ DMM6UPD MN Histone deacetylase 1 (HDAC1) DMM6UPD MT DTT DMM6UPD MA Inhibitor DMM6UPD RN Design and synthesis of a novel class of histone deacetylase inhibitors. Bioorg Med Chem Lett. 2001 Nov 5;11(21):2847-50. DMM6UPD RU https://pubmed.ncbi.nlm.nih.gov/11597413 DMVSNPB DI DMVSNPB DMVSNPB DN 4-benzhydryl-N-butylpiperazine-1-carboxamide DMVSNPB MI TT6OEDT DMVSNPB MN Cannabinoid receptor 1 (CB1) DMVSNPB MT DTT DMVSNPB MA Inhibitor DMVSNPB RN Discovery of benzhydrylpiperazine derivatives as CB1 receptor inverse agonists via privileged structure-based approach. Eur J Med Chem. 2010 Mar;45(3):1133-9. DMVSNPB RU https://pubmed.ncbi.nlm.nih.gov/20047779 DMVSNPB DI DMVSNPB DMVSNPB DN 4-benzhydryl-N-butylpiperazine-1-carboxamide DMVSNPB MI TTMSFAW DMVSNPB MN Cannabinoid receptor 2 (CB2) DMVSNPB MT DTT DMVSNPB MA Inhibitor DMVSNPB RN Discovery of benzhydrylpiperazine derivatives as CB1 receptor inverse agonists via privileged structure-based approach. Eur J Med Chem. 2010 Mar;45(3):1133-9. DMVSNPB RU https://pubmed.ncbi.nlm.nih.gov/20047779 DMASO86 DI DMASO86 DMASO86 DN 4-benzhydryl-N-cyclohexylpiperazine-1-carboxamide DMASO86 MI TT6OEDT DMASO86 MN Cannabinoid receptor 1 (CB1) DMASO86 MT DTT DMASO86 MA Inhibitor DMASO86 RN Discovery of benzhydrylpiperazine derivatives as CB1 receptor inverse agonists via privileged structure-based approach. Eur J Med Chem. 2010 Mar;45(3):1133-9. DMASO86 RU https://pubmed.ncbi.nlm.nih.gov/20047779 DMASO86 DI DMASO86 DMASO86 DN 4-benzhydryl-N-cyclohexylpiperazine-1-carboxamide DMASO86 MI TTMSFAW DMASO86 MN Cannabinoid receptor 2 (CB2) DMASO86 MT DTT DMASO86 MA Inhibitor DMASO86 RN Discovery of benzhydrylpiperazine derivatives as CB1 receptor inverse agonists via privileged structure-based approach. Eur J Med Chem. 2010 Mar;45(3):1133-9. DMASO86 RU https://pubmed.ncbi.nlm.nih.gov/20047779 DM02Q8N DI DM02Q8N DM02Q8N DN 4-Benzo[b]thiophen-4-yl-1H-imidazole DM02Q8N MI TTNGILX DM02Q8N MN Adrenergic receptor alpha-1A (ADRA1A) DM02Q8N MT DTT DM02Q8N MA Inhibitor DM02Q8N RN alpha(2) Adrenoceptor agonists as potential analgesic agents. 2. Discovery of 4-(4-Imidazo)-1,3-dimethyl-6,7-dihydrothianaphthene [corrected] as a ... J Med Chem. 2000 Mar 9;43(5):765-8. DM02Q8N RU https://pubmed.ncbi.nlm.nih.gov/10715142 DM02Q8N DI DM02Q8N DM02Q8N DN 4-Benzo[b]thiophen-4-yl-1H-imidazole DM02Q8N MI TTBRKXS DM02Q8N MN Adrenergic receptor alpha-1B (ADRA1B) DM02Q8N MT DTT DM02Q8N MA Inhibitor DM02Q8N RN alpha(2) Adrenoceptor agonists as potential analgesic agents. 2. Discovery of 4-(4-Imidazo)-1,3-dimethyl-6,7-dihydrothianaphthene [corrected] as a ... J Med Chem. 2000 Mar 9;43(5):765-8. DM02Q8N RU https://pubmed.ncbi.nlm.nih.gov/10715142 DM02Q8N DI DM02Q8N DM02Q8N DN 4-Benzo[b]thiophen-4-yl-1H-imidazole DM02Q8N MI TT34BHT DM02Q8N MN Adrenergic receptor alpha-1D (ADRA1D) DM02Q8N MT DTT DM02Q8N MA Inhibitor DM02Q8N RN alpha(2) Adrenoceptor agonists as potential analgesic agents. 2. Discovery of 4-(4-Imidazo)-1,3-dimethyl-6,7-dihydrothianaphthene [corrected] as a ... J Med Chem. 2000 Mar 9;43(5):765-8. DM02Q8N RU https://pubmed.ncbi.nlm.nih.gov/10715142 DM02Q8N DI DM02Q8N DM02Q8N DN 4-Benzo[b]thiophen-4-yl-1H-imidazole DM02Q8N MI TTWG9A4 DM02Q8N MN Adrenergic receptor alpha-2A (ADRA2A) DM02Q8N MT DTT DM02Q8N MA Inhibitor DM02Q8N RN Alpha(2) adrenoceptor agonists as potential analgesic agents. 2. Discovery of 4-(4-imidazo)-1,3-dimethyl-6,7-dihydro-thianaphthene as a high-affini... J Med Chem. 2000 Apr 6;43(7):1423-6. DM02Q8N RU https://pubmed.ncbi.nlm.nih.gov/10753480 DM02Q8N DI DM02Q8N DM02Q8N DN 4-Benzo[b]thiophen-4-yl-1H-imidazole DM02Q8N MI TTWM4TY DM02Q8N MN Adrenergic receptor alpha-2B (ADRA2B) DM02Q8N MT DTT DM02Q8N MA Inhibitor DM02Q8N RN alpha(2) Adrenoceptor agonists as potential analgesic agents. 2. Discovery of 4-(4-Imidazo)-1,3-dimethyl-6,7-dihydrothianaphthene [corrected] as a ... J Med Chem. 2000 Mar 9;43(5):765-8. DM02Q8N RU https://pubmed.ncbi.nlm.nih.gov/10715142 DM1UG2A DI DM1UG2A DM1UG2A DN 4-Benzo[d]isoxazol-3-yl-benzene-1,3-diol DM1UG2A MI TTZAYWL DM1UG2A MN Estrogen receptor (ESR) DM1UG2A MT DTT DM1UG2A MA Inhibitor DM1UG2A RN Design and synthesis of aryl diphenolic azoles as potent and selective estrogen receptor-beta ligands. J Med Chem. 2004 Oct 7;47(21):5021-40. DM1UG2A RU https://pubmed.ncbi.nlm.nih.gov/15456246 DM1UG2A DI DM1UG2A DM1UG2A DN 4-Benzo[d]isoxazol-3-yl-benzene-1,3-diol DM1UG2A MI TTOM3J0 DM1UG2A MN Estrogen receptor beta (ESR2) DM1UG2A MT DTT DM1UG2A MA Inhibitor DM1UG2A RN Design and synthesis of aryl diphenolic azoles as potent and selective estrogen receptor-beta ligands. J Med Chem. 2004 Oct 7;47(21):5021-40. DM1UG2A RU https://pubmed.ncbi.nlm.nih.gov/15456246 DM7AOGD DI DM7AOGD DM7AOGD DN 4-Benzoimidazol-1-yl-phenylamine DM7AOGD MI TT8FYO9 DM7AOGD MN Platelet-derived growth factor receptor alpha (PDGFRA) DM7AOGD MT DTT DM7AOGD MA Inhibitor DM7AOGD RN Structure-activity relationships for 1-phenylbenzimidazoles as selective ATP site inhibitors of the platelet-derived growth factor receptor. J Med Chem. 1998 Dec 31;41(27):5457-65. DM7AOGD RU https://pubmed.ncbi.nlm.nih.gov/9876115 DM7AOGD DI DM7AOGD DM7AOGD DN 4-Benzoimidazol-1-yl-phenylamine DM7AOGD MI TTI7421 DM7AOGD MN Platelet-derived growth factor receptor beta (PDGFRB) DM7AOGD MT DTT DM7AOGD MA Inhibitor DM7AOGD RN Structure-activity relationships for 1-phenylbenzimidazoles as selective ATP site inhibitors of the platelet-derived growth factor receptor. J Med Chem. 1998 Dec 31;41(27):5457-65. DM7AOGD RU https://pubmed.ncbi.nlm.nih.gov/9876115 DMA9DHE DI DMA9DHE DMA9DHE DN 4-Benzoxazo-2-yl-1,4-diazabicyclo[3.2.2]nonane DMA9DHE MI TTPC4TU DMA9DHE MN 5-HT 3A receptor (HTR3A) DMA9DHE MT DTT DMA9DHE MA Inhibitor DMA9DHE RN Discovery of 4-(5-methyloxazolo[4,5-b]pyridin-2-yl)-1,4-diazabicyclo[3.2.2]nonane (CP-810,123), a novel alpha 7 nicotinic acetylcholine receptor ag... J Med Chem. 2010 Feb 11;53(3):1222-37. DMA9DHE RU https://pubmed.ncbi.nlm.nih.gov/20043678 DMYBPFS DI DMYBPFS DMYBPFS DN 4-Benzoylamino-N-hydroxy-benzamide DMYBPFS MI TTBH0VX DMYBPFS MN Histone deacetylase (HDAC) DMYBPFS MT DTT DMYBPFS MA Inhibitor DMYBPFS RN Structure-based optimization of phenylbutyrate-derived histone deacetylase inhibitors. J Med Chem. 2005 Aug 25;48(17):5530-5. DMYBPFS RU https://pubmed.ncbi.nlm.nih.gov/16107152 DMYBPFS DI DMYBPFS DMYBPFS DN 4-Benzoylamino-N-hydroxy-benzamide DMYBPFS MI TT6R7JZ DMYBPFS MN Histone deacetylase 1 (HDAC1) DMYBPFS MT DTT DMYBPFS MA Inhibitor DMYBPFS RN Structure-based optimization of phenylbutyrate-derived histone deacetylase inhibitors. J Med Chem. 2005 Aug 25;48(17):5530-5. DMYBPFS RU https://pubmed.ncbi.nlm.nih.gov/16107152 DMYBPFS DI DMYBPFS DMYBPFS DN 4-Benzoylamino-N-hydroxy-benzamide DMYBPFS MI TTYHPU6 DMYBPFS MN Histone deacetylase 10 (HDAC10) DMYBPFS MT DTT DMYBPFS MA Inhibitor DMYBPFS RN Structure-based optimization of phenylbutyrate-derived histone deacetylase inhibitors. J Med Chem. 2005 Aug 25;48(17):5530-5. DMYBPFS RU https://pubmed.ncbi.nlm.nih.gov/16107152 DMYBPFS DI DMYBPFS DMYBPFS DN 4-Benzoylamino-N-hydroxy-benzamide DMYBPFS MI TTSHTOI DMYBPFS MN Histone deacetylase 2 (HDAC2) DMYBPFS MT DTT DMYBPFS MA Inhibitor DMYBPFS RN Structure-based optimization of phenylbutyrate-derived histone deacetylase inhibitors. J Med Chem. 2005 Aug 25;48(17):5530-5. DMYBPFS RU https://pubmed.ncbi.nlm.nih.gov/16107152 DMYBPFS DI DMYBPFS DMYBPFS DN 4-Benzoylamino-N-hydroxy-benzamide DMYBPFS MI TTTQGH8 DMYBPFS MN Histone deacetylase 4 (HDAC4) DMYBPFS MT DTT DMYBPFS MA Inhibitor DMYBPFS RN Structure-based optimization of phenylbutyrate-derived histone deacetylase inhibitors. J Med Chem. 2005 Aug 25;48(17):5530-5. DMYBPFS RU https://pubmed.ncbi.nlm.nih.gov/16107152 DMYBPFS DI DMYBPFS DMYBPFS DN 4-Benzoylamino-N-hydroxy-benzamide DMYBPFS MI TT5ZKDI DMYBPFS MN Histone deacetylase 6 (HDAC6) DMYBPFS MT DTT DMYBPFS MA Inhibitor DMYBPFS RN Structure-based optimization of phenylbutyrate-derived histone deacetylase inhibitors. J Med Chem. 2005 Aug 25;48(17):5530-5. DMYBPFS RU https://pubmed.ncbi.nlm.nih.gov/16107152 DMYBPFS DI DMYBPFS DMYBPFS DN 4-Benzoylamino-N-hydroxy-benzamide DMYBPFS MI TTT6LFV DMYBPFS MN Histone deacetylase 8 (HDAC8) DMYBPFS MT DTT DMYBPFS MA Inhibitor DMYBPFS RN Structure-based optimization of phenylbutyrate-derived histone deacetylase inhibitors. J Med Chem. 2005 Aug 25;48(17):5530-5. DMYBPFS RU https://pubmed.ncbi.nlm.nih.gov/16107152 DMQZ0D6 DI DMQZ0D6 DMQZ0D6 DN 4-Benzyl-1-(2-phenoxy-ethyl)-piperidine DMQZ0D6 MI TTLD29N DMQZ0D6 MN Glutamate receptor ionotropic NMDA 1 (NMDAR1) DMQZ0D6 MT DTT DMQZ0D6 MA Inhibitor DMQZ0D6 RN 4-Hydroxy-1-[2-(4-hydroxyphenoxy)ethyl]-4-(4-methylbenzyl)piperidine: a novel, potent, and selective NR1/2B NMDA receptor antagonist. J Med Chem. 1999 Jul 29;42(15):2993-3000. DMQZ0D6 RU https://pubmed.ncbi.nlm.nih.gov/10425109 DMQZ0D6 DI DMQZ0D6 DMQZ0D6 DN 4-Benzyl-1-(2-phenoxy-ethyl)-piperidine DMQZ0D6 MI TTN9D8E DMQZ0D6 MN Glutamate receptor ionotropic NMDA 2B (NMDAR2B) DMQZ0D6 MT DTT DMQZ0D6 MA Inhibitor DMQZ0D6 RN 4-Hydroxy-1-[2-(4-hydroxyphenoxy)ethyl]-4-(4-methylbenzyl)piperidine: a novel, potent, and selective NR1/2B NMDA receptor antagonist. J Med Chem. 1999 Jul 29;42(15):2993-3000. DMQZ0D6 RU https://pubmed.ncbi.nlm.nih.gov/10425109 DMIX6RG DI DMIX6RG DMIX6RG DN 4-Benzyl-1-[3-phenylpropoxy)propyl]piperidine DMIX6RG MI TT9JNIC DMIX6RG MN Histamine H3 receptor (H3R) DMIX6RG MT DTT DMIX6RG MA Inhibitor DMIX6RG RN Piperidine variations in search for non-imidazole histamine H(3) receptor ligands. Bioorg Med Chem. 2008 Sep 15;16(18):8729-36. DMIX6RG RU https://pubmed.ncbi.nlm.nih.gov/18774720 DM6XLZ0 DI DM6XLZ0 DM6XLZ0 DN 4-Benzyl-1-chroman-2-ylmethyl-piperidine DM6XLZ0 MI TTSQIFT DM6XLZ0 MN 5-HT 1A receptor (HTR1A) DM6XLZ0 MT DTT DM6XLZ0 MA Inhibitor DM6XLZ0 RN Synthesis and structure-activity relationships of 1-aralkyl-4-benzylpiperidine and 1-aralkyl-4-benzylpiperazine derivatives as potent sigma ligands. J Med Chem. 2005 Jan 13;48(1):266-73. DM6XLZ0 RU https://pubmed.ncbi.nlm.nih.gov/15634021 DM6XLZ0 DI DM6XLZ0 DM6XLZ0 DN 4-Benzyl-1-chroman-2-ylmethyl-piperidine DM6XLZ0 MI TTEX248 DM6XLZ0 MN Dopamine D2 receptor (D2R) DM6XLZ0 MT DTT DM6XLZ0 MA Inhibitor DM6XLZ0 RN Synthesis and structure-activity relationships of 1-aralkyl-4-benzylpiperidine and 1-aralkyl-4-benzylpiperazine derivatives as potent sigma ligands. J Med Chem. 2005 Jan 13;48(1):266-73. DM6XLZ0 RU https://pubmed.ncbi.nlm.nih.gov/15634021 DMAZMPF DI DMAZMPF DMAZMPF DN 4-Benzyl-1-chroman-3-ylmethyl-piperidine DMAZMPF MI TTSQIFT DMAZMPF MN 5-HT 1A receptor (HTR1A) DMAZMPF MT DTT DMAZMPF MA Inhibitor DMAZMPF RN Synthesis and structure-activity relationships of 1-aralkyl-4-benzylpiperidine and 1-aralkyl-4-benzylpiperazine derivatives as potent sigma ligands. J Med Chem. 2005 Jan 13;48(1):266-73. DMAZMPF RU https://pubmed.ncbi.nlm.nih.gov/15634021 DMAZMPF DI DMAZMPF DMAZMPF DN 4-Benzyl-1-chroman-3-ylmethyl-piperidine DMAZMPF MI TTEX248 DMAZMPF MN Dopamine D2 receptor (D2R) DMAZMPF MT DTT DMAZMPF MA Inhibitor DMAZMPF RN Synthesis and structure-activity relationships of 1-aralkyl-4-benzylpiperidine and 1-aralkyl-4-benzylpiperazine derivatives as potent sigma ligands. J Med Chem. 2005 Jan 13;48(1):266-73. DMAZMPF RU https://pubmed.ncbi.nlm.nih.gov/15634021 DMES9AJ DI DMES9AJ DMES9AJ DN 4-Benzyl-1-indan-2-ylmethyl-piperidine DMES9AJ MI TTEX248 DMES9AJ MN Dopamine D2 receptor (D2R) DMES9AJ MT DTT DMES9AJ MA Inhibitor DMES9AJ RN Synthesis and structure-activity relationships of 1-aralkyl-4-benzylpiperidine and 1-aralkyl-4-benzylpiperazine derivatives as potent sigma ligands. J Med Chem. 2005 Jan 13;48(1):266-73. DMES9AJ RU https://pubmed.ncbi.nlm.nih.gov/15634021 DMQKCGI DI DMQKCGI DMQKCGI DN 4-Benzyl-1-methyl-piperidine hydrochloride DMQKCGI MI TTJQOD7 DMQKCGI MN 5-HT 2A receptor (HTR2A) DMQKCGI MT DTT DMQKCGI MA Inhibitor DMQKCGI RN Ketanserin analogues: structure-affinity relationships for 5-HT2 and 5-HT1C serotonin receptor binding. J Med Chem. 1992 Dec 25;35(26):4903-10. DMQKCGI RU https://pubmed.ncbi.nlm.nih.gov/1479590 DMAI6X2 DI DMAI6X2 DMAI6X2 DN 4-Benzyl-1-phenethyl-piperidine hydrochloride DMAI6X2 MI TTLD29N DMAI6X2 MN Glutamate receptor ionotropic NMDA 1 (NMDAR1) DMAI6X2 MT DTT DMAI6X2 MA Inhibitor DMAI6X2 RN Structure-activity relationships for a series of bis(phenylalkyl)amines: potent subtype-selective inhibitors of N-methyl-D-aspartate receptors. J Med Chem. 1998 Aug 27;41(18):3499-506. DMAI6X2 RU https://pubmed.ncbi.nlm.nih.gov/9719603 DMAI6X2 DI DMAI6X2 DMAI6X2 DN 4-Benzyl-1-phenethyl-piperidine hydrochloride DMAI6X2 MI TTN9D8E DMAI6X2 MN Glutamate receptor ionotropic NMDA 2B (NMDAR2B) DMAI6X2 MT DTT DMAI6X2 MA Inhibitor DMAI6X2 RN Structure-activity relationships for a series of bis(phenylalkyl)amines: potent subtype-selective inhibitors of N-methyl-D-aspartate receptors. J Med Chem. 1998 Aug 27;41(18):3499-506. DMAI6X2 RU https://pubmed.ncbi.nlm.nih.gov/9719603 DM2Q0VB DI DM2Q0VB DM2Q0VB DN 4-benzyl-2,6-diisobutylamino-pyrimidine DM2Q0VB MI TTZAYWL DM2Q0VB MN Estrogen receptor (ESR) DM2Q0VB MT DTT DM2Q0VB MA Inhibitor DM2Q0VB RN Blocking estrogen signaling after the hormone: pyrimidine-core inhibitors of estrogen receptor-coactivator binding. J Med Chem. 2008 Oct 23;51(20):6512-30. DM2Q0VB RU https://pubmed.ncbi.nlm.nih.gov/18785725 DM8MVU4 DI DM8MVU4 DM8MVU4 DN 4-benzyl-2-methylphthalazin-1(2H)-one DM8MVU4 MI TTNGILX DM8MVU4 MN Adrenergic receptor alpha-1A (ADRA1A) DM8MVU4 MT DTT DM8MVU4 MA Inhibitor DM8MVU4 RN Vasorelaxant activity of phthalazinones and related compounds. Bioorg Med Chem Lett. 2006 May 15;16(10):2786-90. DM8MVU4 RU https://pubmed.ncbi.nlm.nih.gov/16513345 DM8MVU4 DI DM8MVU4 DM8MVU4 DN 4-benzyl-2-methylphthalazin-1(2H)-one DM8MVU4 MI TT34BHT DM8MVU4 MN Adrenergic receptor alpha-1D (ADRA1D) DM8MVU4 MT DTT DM8MVU4 MA Inhibitor DM8MVU4 RN Vasorelaxant activity of phthalazinones and related compounds. Bioorg Med Chem Lett. 2006 May 15;16(10):2786-90. DM8MVU4 RU https://pubmed.ncbi.nlm.nih.gov/16513345 DMZ18OJ DI DMZ18OJ DMZ18OJ DN 4-benzyl-5-(4-piperidyl)isothiazol-3-ol DMZ18OJ MI TT1MPAY DMZ18OJ MN GABA(A) receptor alpha-1 (GABRA1) DMZ18OJ MT DTT DMZ18OJ MA Inhibitor DMZ18OJ RN Potent 4-arylalkyl-substituted 3-isothiazolol GABA(A) competitive/noncompetitive antagonists: synthesis and pharmacology. J Med Chem. 2006 Feb 23;49(4):1388-96. DMZ18OJ RU https://pubmed.ncbi.nlm.nih.gov/16480274 DMZ18OJ DI DMZ18OJ DMZ18OJ DN 4-benzyl-5-(4-piperidyl)isothiazol-3-ol DMZ18OJ MI TT06RH5 DMZ18OJ MN GABA(A) receptor gamma-2 (GABRG2) DMZ18OJ MT DTT DMZ18OJ MA Inhibitor DMZ18OJ RN Potent 4-arylalkyl-substituted 3-isothiazolol GABA(A) competitive/noncompetitive antagonists: synthesis and pharmacology. J Med Chem. 2006 Feb 23;49(4):1388-96. DMZ18OJ RU https://pubmed.ncbi.nlm.nih.gov/16480274 DMZ18OJ DI DMZ18OJ DMZ18OJ DN 4-benzyl-5-(4-piperidyl)isothiazol-3-ol DMZ18OJ MI TTNJYV2 DMZ18OJ MN Gamma-aminobutyric acid receptor (GAR) DMZ18OJ MT DTT DMZ18OJ MA Inhibitor DMZ18OJ RN Potent 4-arylalkyl-substituted 3-isothiazolol GABA(A) competitive/noncompetitive antagonists: synthesis and pharmacology. J Med Chem. 2006 Feb 23;49(4):1388-96. DMZ18OJ RU https://pubmed.ncbi.nlm.nih.gov/16480274 DMA4CZK DI DMA4CZK DMA4CZK DN 4-Benzyl-5-piperidin-4-yl-isoxazol-3-ol DMA4CZK MI TT1MPAY DMA4CZK MN GABA(A) receptor alpha-1 (GABRA1) DMA4CZK MT DTT DMA4CZK MA Inhibitor DMA4CZK RN Potent 4-aryl- or 4-arylalkyl-substituted 3-isoxazolol GABA(A) antagonists: synthesis, pharmacology, and molecular modeling. J Med Chem. 2005 Jan 27;48(2):427-39. DMA4CZK RU https://pubmed.ncbi.nlm.nih.gov/15658856 DMA4CZK DI DMA4CZK DMA4CZK DN 4-Benzyl-5-piperidin-4-yl-isoxazol-3-ol DMA4CZK MI TTZA1NY DMA4CZK MN GABA(A) receptor beta-2 (GABRB2) DMA4CZK MT DTT DMA4CZK MA Inhibitor DMA4CZK RN Potent 4-aryl- or 4-arylalkyl-substituted 3-isoxazolol GABA(A) antagonists: synthesis, pharmacology, and molecular modeling. J Med Chem. 2005 Jan 27;48(2):427-39. DMA4CZK RU https://pubmed.ncbi.nlm.nih.gov/15658856 DMA4CZK DI DMA4CZK DMA4CZK DN 4-Benzyl-5-piperidin-4-yl-isoxazol-3-ol DMA4CZK MI TT06RH5 DMA4CZK MN GABA(A) receptor gamma-2 (GABRG2) DMA4CZK MT DTT DMA4CZK MA Inhibitor DMA4CZK RN Potent 4-aryl- or 4-arylalkyl-substituted 3-isoxazolol GABA(A) antagonists: synthesis, pharmacology, and molecular modeling. J Med Chem. 2005 Jan 27;48(2):427-39. DMA4CZK RU https://pubmed.ncbi.nlm.nih.gov/15658856 DMA4CZK DI DMA4CZK DMA4CZK DN 4-Benzyl-5-piperidin-4-yl-isoxazol-3-ol DMA4CZK MI TTNJYV2 DMA4CZK MN Gamma-aminobutyric acid receptor (GAR) DMA4CZK MT DTT DMA4CZK MA Inhibitor DMA4CZK RN Potent 4-aryl- or 4-arylalkyl-substituted 3-isoxazolol GABA(A) antagonists: synthesis, pharmacology, and molecular modeling. J Med Chem. 2005 Jan 27;48(2):427-39. DMA4CZK RU https://pubmed.ncbi.nlm.nih.gov/15658856 DMOBC0F DI DMOBC0F DMOBC0F DN 4-Benzyl-6-nitro-2-piperazin-1-yl-quinoline DMOBC0F MI TT3ROYC DMOBC0F MN Serotonin transporter (SERT) DMOBC0F MT DTT DMOBC0F MA Inhibitor DMOBC0F RN Syntheses and binding affinities of 6-nitroquipazine analogues for serotonin transporter. Part 2: 4-substituted 6-nitroquipazines. Bioorg Med Chem Lett. 2002 Mar 11;12(5):811-5. DMOBC0F RU https://pubmed.ncbi.nlm.nih.gov/11859009 DMDC7TL DI DMDC7TL DMDC7TL DN 4-benzyloxy-2'-hydroxychalcone DMDC7TL MI TTVKILB DMDC7TL MN Prostaglandin G/H synthase 2 (COX-2) DMDC7TL MT DTT DMDC7TL MA Inhibitor DMDC7TL RN Inhibitory activity of prostaglandin E2 production by the synthetic 2'-hydroxychalcone analogues: Synthesis and SAR study. Bioorg Med Chem Lett. 2009 Mar 15;19(6):1650-3. DMDC7TL RU https://pubmed.ncbi.nlm.nih.gov/19233646 DM0T1NZ DI DM0T1NZ DM0T1NZ DN 4-Benzyloxybenzo[b]thiophene-2-carboxamidine DM0T1NZ MI TTFEZ5Q DM0T1NZ MN Coagulation factor IX (F9) DM0T1NZ MT DTT DM0T1NZ MA Inhibitor DM0T1NZ RN Studies of benzothiophene template as potent factor IXa (FIXa) inhibitors in thrombosis. J Med Chem. 2010 Feb 25;53(4):1465-72. DM0T1NZ RU https://pubmed.ncbi.nlm.nih.gov/20121198 DMA5FEM DI DMA5FEM DMA5FEM DN 4-benzylphthalazin-1(2H)-one DMA5FEM MI TTVDSZ0 DMA5FEM MN Poly [ADP-ribose] polymerase 1 (PARP1) DMA5FEM MT DTT DMA5FEM MA Inhibitor DMA5FEM RN Design, synthesis, and cytoprotective effect of 2-aminothiazole analogues as potent poly(ADP-ribose) polymerase-1 inhibitors. J Med Chem. 2009 Feb 12;52(3):718-25. DMA5FEM RU https://pubmed.ncbi.nlm.nih.gov/19125579 DMI1EFY DI DMI1EFY DMI1EFY DN 4-Benzythiopyridine-3-sulfonamide DMI1EFY MI TTHQPL7 DMI1EFY MN Carbonic anhydrase I (CA-I) DMI1EFY MT DTT DMI1EFY MA Inhibitor DMI1EFY RN Carbonic anhydrase inhibitors: synthesis and inhibition of the human cytosolic isozymes I and II and transmembrane isozymes IX, XII (cancer-associa... Eur J Med Chem. 2010 Jun;45(6):2396-404. DMI1EFY RU https://pubmed.ncbi.nlm.nih.gov/20202722 DMI1EFY DI DMI1EFY DMI1EFY DN 4-Benzythiopyridine-3-sulfonamide DMI1EFY MI TTANPDJ DMI1EFY MN Carbonic anhydrase II (CA-II) DMI1EFY MT DTT DMI1EFY MA Inhibitor DMI1EFY RN Carbonic anhydrase inhibitors: synthesis and inhibition of the human cytosolic isozymes I and II and transmembrane isozymes IX, XII (cancer-associa... Eur J Med Chem. 2010 Jun;45(6):2396-404. DMI1EFY RU https://pubmed.ncbi.nlm.nih.gov/20202722 DMI1EFY DI DMI1EFY DMI1EFY DN 4-Benzythiopyridine-3-sulfonamide DMI1EFY MI TT2LVK8 DMI1EFY MN Carbonic anhydrase IX (CA-IX) DMI1EFY MT DTT DMI1EFY MA Inhibitor DMI1EFY RN Carbonic anhydrase inhibitors: synthesis and inhibition of the human cytosolic isozymes I and II and transmembrane isozymes IX, XII (cancer-associa... Eur J Med Chem. 2010 Jun;45(6):2396-404. DMI1EFY RU https://pubmed.ncbi.nlm.nih.gov/20202722 DMI1EFY DI DMI1EFY DMI1EFY DN 4-Benzythiopyridine-3-sulfonamide DMI1EFY MI TTSYM0R DMI1EFY MN Carbonic anhydrase XII (CA-XII) DMI1EFY MT DTT DMI1EFY MA Inhibitor DMI1EFY RN Carbonic anhydrase inhibitors: synthesis and inhibition of the human cytosolic isozymes I and II and transmembrane isozymes IX, XII (cancer-associa... Eur J Med Chem. 2010 Jun;45(6):2396-404. DMI1EFY RU https://pubmed.ncbi.nlm.nih.gov/20202722 DMI1EFY DI DMI1EFY DMI1EFY DN 4-Benzythiopyridine-3-sulfonamide DMI1EFY MI TTEYTKG DMI1EFY MN Carbonic anhydrase XIV (CA-XIV) DMI1EFY MT DTT DMI1EFY MA Inhibitor DMI1EFY RN Carbonic anhydrase inhibitors: synthesis and inhibition of the human cytosolic isozymes I and II and transmembrane isozymes IX, XII (cancer-associa... Eur J Med Chem. 2010 Jun;45(6):2396-404. DMI1EFY RU https://pubmed.ncbi.nlm.nih.gov/20202722 DMDF3KJ DI DMDF3KJ DMDF3KJ DN 4beta,15-epoxy-miller-9E-enolide DMDF3KJ MI TTSXVID DMDF3KJ MN Nuclear factor NF-kappa-B (NFKB) DMDF3KJ MT DTT DMDF3KJ MA Inhibitor DMDF3KJ RN Development of a structural model for NF-kappaB inhibition of sesquiterpene lactones using self-organizing neural networks. J Med Chem. 2006 Apr 6;49(7):2241-52. DMDF3KJ RU https://pubmed.ncbi.nlm.nih.gov/16570920 DMZ01SV DI DMZ01SV DMZ01SV DN 4beta,15-epoxy-miller-9Z-enolide DMZ01SV MI TTSXVID DMZ01SV MN Nuclear factor NF-kappa-B (NFKB) DMZ01SV MT DTT DMZ01SV MA Inhibitor DMZ01SV RN Development of a structural model for NF-kappaB inhibition of sesquiterpene lactones using self-organizing neural networks. J Med Chem. 2006 Apr 6;49(7):2241-52. DMZ01SV RU https://pubmed.ncbi.nlm.nih.gov/16570920 DM3B2TG DI DM3B2TG DM3B2TG DN 4-Biphenyl-2-ylethynyl-2-methyl-thiazole DM3B2TG MI TTHS256 DM3B2TG MN Metabotropic glutamate receptor 5 (mGluR5) DM3B2TG MT DTT DM3B2TG MA Inhibitor DM3B2TG RN 5-[(2-Methyl-1,3-thiazol-4-yl)ethynyl]-2,3'-bipyridine: a highly potent, orally active metabotropic glutamate subtype 5 (mGlu5) receptor antagonist... Bioorg Med Chem Lett. 2004 Aug 2;14(15):3993-6. DM3B2TG RU https://pubmed.ncbi.nlm.nih.gov/15225713 DMYUL9J DI DMYUL9J DMYUL9J DN 4-biphenyl-2-ylethynyl-6,7-dimethoxy-quinazoline DMYUL9J MI TTGKNB4 DMYUL9J MN Epidermal growth factor receptor (EGFR) DMYUL9J MT DTT DMYUL9J MA Inhibitor DMYUL9J RN Synthesis and inhibitory activity of 4-alkynyl and 4-alkenylquinazolines: identification of new scaffolds for potent EGFR tyrosine kinase inhibitors. Bioorg Med Chem Lett. 2007 Nov 1;17(21):5863-7. DMYUL9J RU https://pubmed.ncbi.nlm.nih.gov/17869510 DML6PTX DI DML6PTX DML6PTX DN 4-Biphenyl-4-yl-2-(1-pentyl-hexyl)-1H-imidazole DML6PTX MI TTRK8B9 DML6PTX MN Sodium channel unspecific (NaC) DML6PTX MT DTT DML6PTX MA Inhibitor DML6PTX RN 2-Alkyl-4-arylimidazoles: structurally novel sodium channel modulators. Bioorg Med Chem Lett. 2004 Jul 5;14(13):3521-3. DML6PTX RU https://pubmed.ncbi.nlm.nih.gov/15177465 DML6PTX DI DML6PTX DML6PTX DN 4-Biphenyl-4-yl-2-(1-pentyl-hexyl)-1H-imidazole DML6PTX MI TTAXZ0K DML6PTX MN Voltage-gated sodium channel alpha Nav1.3 (SCN3A) DML6PTX MT DTT DML6PTX MA Inhibitor DML6PTX RN 2-Alkyl-4-arylimidazoles: structurally novel sodium channel modulators. Bioorg Med Chem Lett. 2004 Jul 5;14(13):3521-3. DML6PTX RU https://pubmed.ncbi.nlm.nih.gov/15177465 DM2I13S DI DM2I13S DM2I13S DN 4-Biphenyl-4-yl-2-(1-propyl-butyl)-1H-imidazole DM2I13S MI TTRK8B9 DM2I13S MN Sodium channel unspecific (NaC) DM2I13S MT DTT DM2I13S MA Inhibitor DM2I13S RN 2-Alkyl-4-arylimidazoles: structurally novel sodium channel modulators. Bioorg Med Chem Lett. 2004 Jul 5;14(13):3521-3. DM2I13S RU https://pubmed.ncbi.nlm.nih.gov/15177465 DM2I13S DI DM2I13S DM2I13S DN 4-Biphenyl-4-yl-2-(1-propyl-butyl)-1H-imidazole DM2I13S MI TTAXZ0K DM2I13S MN Voltage-gated sodium channel alpha Nav1.3 (SCN3A) DM2I13S MT DTT DM2I13S MA Inhibitor DM2I13S RN 2-Alkyl-4-arylimidazoles: structurally novel sodium channel modulators. Bioorg Med Chem Lett. 2004 Jul 5;14(13):3521-3. DM2I13S RU https://pubmed.ncbi.nlm.nih.gov/15177465 DMLSUXD DI DMLSUXD DMLSUXD DN 4-Biphenyl-4-yl-2-cyclohexylmethyl-1H-imidazole DMLSUXD MI TTRK8B9 DMLSUXD MN Sodium channel unspecific (NaC) DMLSUXD MT DTT DMLSUXD MA Inhibitor DMLSUXD RN 2-Alkyl-4-arylimidazoles: structurally novel sodium channel modulators. Bioorg Med Chem Lett. 2004 Jul 5;14(13):3521-3. DMLSUXD RU https://pubmed.ncbi.nlm.nih.gov/15177465 DMLSUXD DI DMLSUXD DMLSUXD DN 4-Biphenyl-4-yl-2-cyclohexylmethyl-1H-imidazole DMLSUXD MI TTAXZ0K DMLSUXD MN Voltage-gated sodium channel alpha Nav1.3 (SCN3A) DMLSUXD MT DTT DMLSUXD MA Inhibitor DMLSUXD RN 2-Alkyl-4-arylimidazoles: structurally novel sodium channel modulators. Bioorg Med Chem Lett. 2004 Jul 5;14(13):3521-3. DMLSUXD RU https://pubmed.ncbi.nlm.nih.gov/15177465 DMPIH4L DI DMPIH4L DMPIH4L DN 4-Biphenyl-4-yl-2-hexyl-1H-imidazole DMPIH4L MI TTRK8B9 DMPIH4L MN Sodium channel unspecific (NaC) DMPIH4L MT DTT DMPIH4L MA Inhibitor DMPIH4L RN 2-Alkyl-4-arylimidazoles: structurally novel sodium channel modulators. Bioorg Med Chem Lett. 2004 Jul 5;14(13):3521-3. DMPIH4L RU https://pubmed.ncbi.nlm.nih.gov/15177465 DMPIH4L DI DMPIH4L DMPIH4L DN 4-Biphenyl-4-yl-2-hexyl-1H-imidazole DMPIH4L MI TTAXZ0K DMPIH4L MN Voltage-gated sodium channel alpha Nav1.3 (SCN3A) DMPIH4L MT DTT DMPIH4L MA Inhibitor DMPIH4L RN 2-Alkyl-4-arylimidazoles: structurally novel sodium channel modulators. Bioorg Med Chem Lett. 2004 Jul 5;14(13):3521-3. DMPIH4L RU https://pubmed.ncbi.nlm.nih.gov/15177465 DMNLC2Y DI DMNLC2Y DMNLC2Y DN 4-Biphenyl-4-yl-2-methyl-1H-imidazole DMNLC2Y MI TTRK8B9 DMNLC2Y MN Sodium channel unspecific (NaC) DMNLC2Y MT DTT DMNLC2Y MA Inhibitor DMNLC2Y RN 2-Alkyl-4-arylimidazoles: structurally novel sodium channel modulators. Bioorg Med Chem Lett. 2004 Jul 5;14(13):3521-3. DMNLC2Y RU https://pubmed.ncbi.nlm.nih.gov/15177465 DMNLC2Y DI DMNLC2Y DMNLC2Y DN 4-Biphenyl-4-yl-2-methyl-1H-imidazole DMNLC2Y MI TTAXZ0K DMNLC2Y MN Voltage-gated sodium channel alpha Nav1.3 (SCN3A) DMNLC2Y MT DTT DMNLC2Y MA Inhibitor DMNLC2Y RN 2-Alkyl-4-arylimidazoles: structurally novel sodium channel modulators. Bioorg Med Chem Lett. 2004 Jul 5;14(13):3521-3. DMNLC2Y RU https://pubmed.ncbi.nlm.nih.gov/15177465 DMCQYKO DI DMCQYKO DMCQYKO DN 4-Biphenyl-4-ylethynyl-2-methyl-thiazole DMCQYKO MI TTHS256 DMCQYKO MN Metabotropic glutamate receptor 5 (mGluR5) DMCQYKO MT DTT DMCQYKO MA Inhibitor DMCQYKO RN 5-[(2-Methyl-1,3-thiazol-4-yl)ethynyl]-2,3'-bipyridine: a highly potent, orally active metabotropic glutamate subtype 5 (mGlu5) receptor antagonist... Bioorg Med Chem Lett. 2004 Aug 2;14(15):3993-6. DMCQYKO RU https://pubmed.ncbi.nlm.nih.gov/15225713 DMS0JVE DI DMS0JVE DMS0JVE DN 4BP-TQS DMS0JVE MI TTLA931 DMS0JVE MN Neuronal acetylcholine receptor alpha-7 (CHRNA7) DMS0JVE MT DTT DMS0JVE MA Agonist DMS0JVE RN Agonist activation of alpha7 nicotinic acetylcholine receptors via an allosteric transmembrane site. Proc Natl Acad Sci U S A. 2011 Apr 5;108(14):5867-72. DMS0JVE RU https://pubmed.ncbi.nlm.nih.gov/21436053 DM81D90 DI DM81D90 DM81D90 DN 4-bromo-1H-indazole DM81D90 MI TTZUFI5 DM81D90 MN Nitric-oxide synthase brain (NOS1) DM81D90 MT DTT DM81D90 MA Inhibitor DM81D90 RN 4-substituted indazoles as new inhibitors of neuronal nitric oxide synthase. Bioorg Med Chem Lett. 2007 Jun 1;17(11):3177-80. DM81D90 RU https://pubmed.ncbi.nlm.nih.gov/17395463 DMMVASI DI DMMVASI DMMVASI DN 4-Bromo-1-imidazol-1-ylmethyl-xanthen-9-one DMMVASI MI TTSZLWK DMMVASI MN Aromatase (CYP19A1) DMMVASI MT DTT DMMVASI MA Inhibitor DMMVASI RN A new class of nonsteroidal aromatase inhibitors: design and synthesis of chromone and xanthone derivatives and inhibition of the P450 enzymes aromatase and 17 alpha-hydroxylase/C17,20-lyase. J Med Chem. 2001 Mar 1;44(5):672-80. DMMVASI RU https://pubmed.ncbi.nlm.nih.gov/11262078 DMMVASI DI DMMVASI DMMVASI DN 4-Bromo-1-imidazol-1-ylmethyl-xanthen-9-one DMMVASI MI TTRA5BZ DMMVASI MN Steroid 17-alpha-monooxygenase (S17AH) DMMVASI MT DTT DMMVASI MA Inhibitor DMMVASI RN A new class of nonsteroidal aromatase inhibitors: design and synthesis of chromone and xanthone derivatives and inhibition of the P450 enzymes aromatase and 17 alpha-hydroxylase/C17,20-lyase. J Med Chem. 2001 Mar 1;44(5):672-80. DMMVASI RU https://pubmed.ncbi.nlm.nih.gov/11262078 DMPSRAC DI DMPSRAC DMPSRAC DN 4-Bromo-2-(4-hydroxy-phenyl)-quinolin-6-ol DMPSRAC MI TTZAYWL DMPSRAC MN Estrogen receptor (ESR) DMPSRAC MT DTT DMPSRAC MA Inhibitor DMPSRAC RN ERbeta ligands. Part 4: Synthesis and structure-activity relationships of a series of 2-phenylquinoline derivatives. Bioorg Med Chem Lett. 2005 Oct 15;15(20):4520-5. DMPSRAC RU https://pubmed.ncbi.nlm.nih.gov/16098741 DMPSRAC DI DMPSRAC DMPSRAC DN 4-Bromo-2-(4-hydroxy-phenyl)-quinolin-6-ol DMPSRAC MI TTOM3J0 DMPSRAC MN Estrogen receptor beta (ESR2) DMPSRAC MT DTT DMPSRAC MA Inhibitor DMPSRAC RN ERbeta ligands. Part 4: Synthesis and structure-activity relationships of a series of 2-phenylquinoline derivatives. Bioorg Med Chem Lett. 2005 Oct 15;15(20):4520-5. DMPSRAC RU https://pubmed.ncbi.nlm.nih.gov/16098741 DMPSRAC DI DMPSRAC DMPSRAC DN 4-Bromo-2-(4-hydroxy-phenyl)-quinolin-6-ol DMPSRAC MI TTPNQAC DMPSRAC MN Estrogen-related receptor-alpha (ESRRA) DMPSRAC MT DTT DMPSRAC MA Inhibitor DMPSRAC RN ERbeta ligands. Part 6: 6H-Chromeno[4,3-b]quinolines as a new series of estrogen receptor beta-selective ligands. Bioorg Med Chem Lett. 2007 Jul 15;17(14):4053-6. DMPSRAC RU https://pubmed.ncbi.nlm.nih.gov/17482813 DMY8TLO DI DMY8TLO DMY8TLO DN 4-Bromo-2,6-diisopropyl-phenol DMY8TLO MI TTNJYV2 DMY8TLO MN Gamma-aminobutyric acid receptor (GAR) DMY8TLO MT DTT DMY8TLO MA Inhibitor DMY8TLO RN Propofol analogues. Synthesis, relationships between structure and affinity at GABAA receptor in rat brain, and differential electrophysiological p... J Med Chem. 1998 May 21;41(11):1846-54. DMY8TLO RU https://pubmed.ncbi.nlm.nih.gov/9599235 DMK2PBJ DI DMK2PBJ DMK2PBJ DN 4'-bromo-3-(imidazolylmethyl)-7-methoxyflavone DMK2PBJ MI TTSZLWK DMK2PBJ MN Aromatase (CYP19A1) DMK2PBJ MT DTT DMK2PBJ MA Inhibitor DMK2PBJ RN Lead optimization providing a series of flavone derivatives as potent nonsteroidal inhibitors of the cytochrome P450 aromatase enzyme. J Med Chem. 2006 Jul 27;49(15):4777-80. DMK2PBJ RU https://pubmed.ncbi.nlm.nih.gov/16854084 DM2V3S8 DI DM2V3S8 DM2V3S8 DN 4'-bromo-3-(imidazolylmethyl)flavone DM2V3S8 MI TTSZLWK DM2V3S8 MN Aromatase (CYP19A1) DM2V3S8 MT DTT DM2V3S8 MA Inhibitor DM2V3S8 RN Lead optimization providing a series of flavone derivatives as potent nonsteroidal inhibitors of the cytochrome P450 aromatase enzyme. J Med Chem. 2006 Jul 27;49(15):4777-80. DM2V3S8 RU https://pubmed.ncbi.nlm.nih.gov/16854084 DMYOCFX DI DMYOCFX DMYOCFX DN 4-Bromo-3-hydroxy-1H-quinolin-2-one DMYOCFX MI TTLD29N DMYOCFX MN Glutamate receptor ionotropic NMDA 1 (NMDAR1) DMYOCFX MT DTT DMYOCFX MA Inhibitor DMYOCFX RN 3-Hydroxy-quinolin-2-ones: Inhibitors of [3H]-glycine binding to the site associated with the NMDA receptor, Bioorg. Med. Chem. Lett. 6(5):499-504 (1996). DMYOCFX RU http://www.sciencedirect.com/science/article/pii/0960894X96000315 DMYOCFX DI DMYOCFX DMYOCFX DN 4-Bromo-3-hydroxy-1H-quinolin-2-one DMYOCFX MI TTKJEMQ DMYOCFX MN Glutamate receptor ionotropic NMDA 2A (NMDAR2A) DMYOCFX MT DTT DMYOCFX MA Inhibitor DMYOCFX RN 3-Hydroxy-quinolin-2-ones: Inhibitors of [3H]-glycine binding to the site associated with the NMDA receptor, Bioorg. Med. Chem. Lett. 6(5):499-504 (1996). DMYOCFX RU http://www.sciencedirect.com/science/article/pii/0960894X96000315 DMYOCFX DI DMYOCFX DMYOCFX DN 4-Bromo-3-hydroxy-1H-quinolin-2-one DMYOCFX MI TTN9D8E DMYOCFX MN Glutamate receptor ionotropic NMDA 2B (NMDAR2B) DMYOCFX MT DTT DMYOCFX MA Inhibitor DMYOCFX RN 3-Hydroxy-quinolin-2-ones: Inhibitors of [3H]-glycine binding to the site associated with the NMDA receptor, Bioorg. Med. Chem. Lett. 6(5):499-504 (1996). DMYOCFX RU http://www.sciencedirect.com/science/article/pii/0960894X96000315 DM2QJ5A DI DM2QJ5A DM2QJ5A DN 4-Bromo-5,7-dichloro-3-hydroxy-1H-quinolin-2-one DM2QJ5A MI TTLD29N DM2QJ5A MN Glutamate receptor ionotropic NMDA 1 (NMDAR1) DM2QJ5A MT DTT DM2QJ5A MA Inhibitor DM2QJ5A RN 3-Hydroxy-quinolin-2-ones: Inhibitors of [3H]-glycine binding to the site associated with the NMDA receptor, Bioorg. Med. Chem. Lett. 6(5):499-504 (1996). DM2QJ5A RU http://www.sciencedirect.com/science/article/pii/0960894X96000315 DM2QJ5A DI DM2QJ5A DM2QJ5A DN 4-Bromo-5,7-dichloro-3-hydroxy-1H-quinolin-2-one DM2QJ5A MI TTKJEMQ DM2QJ5A MN Glutamate receptor ionotropic NMDA 2A (NMDAR2A) DM2QJ5A MT DTT DM2QJ5A MA Inhibitor DM2QJ5A RN 3-Hydroxy-quinolin-2-ones: Inhibitors of [3H]-glycine binding to the site associated with the NMDA receptor, Bioorg. Med. Chem. Lett. 6(5):499-504 (1996). DM2QJ5A RU http://www.sciencedirect.com/science/article/pii/0960894X96000315 DM2QJ5A DI DM2QJ5A DM2QJ5A DN 4-Bromo-5,7-dichloro-3-hydroxy-1H-quinolin-2-one DM2QJ5A MI TTN9D8E DM2QJ5A MN Glutamate receptor ionotropic NMDA 2B (NMDAR2B) DM2QJ5A MT DTT DM2QJ5A MA Inhibitor DM2QJ5A RN 3-Hydroxy-quinolin-2-ones: Inhibitors of [3H]-glycine binding to the site associated with the NMDA receptor, Bioorg. Med. Chem. Lett. 6(5):499-504 (1996). DM2QJ5A RU http://www.sciencedirect.com/science/article/pii/0960894X96000315 DMH6OPI DI DMH6OPI DMH6OPI DN 4-Bromo-6-nitro-2-piperazin-1-yl-quinoline DMH6OPI MI TT3ROYC DMH6OPI MN Serotonin transporter (SERT) DMH6OPI MT DTT DMH6OPI MA Inhibitor DMH6OPI RN Syntheses and binding affinities of 6-nitroquipazine analogues for serotonin transporter. Part 2: 4-substituted 6-nitroquipazines. Bioorg Med Chem Lett. 2002 Mar 11;12(5):811-5. DMH6OPI RU https://pubmed.ncbi.nlm.nih.gov/11859009 DMJFY9Z DI DMJFY9Z DMJFY9Z DN 4-Bromo-N-(4-phenyl-thiazol-2-yl)-benzamide DMJFY9Z MI TTK25J1 DMJFY9Z MN Adenosine A1 receptor (ADORA1) DMJFY9Z MT DTT DMJFY9Z MA Inhibitor DMJFY9Z RN Substituted 4-phenyl-2-(phenylcarboxamido)-1,3-thiazole derivatives as antagonists for the adenosine A(1) receptor. Bioorg Med Chem Lett. 2001 Aug 6;11(15):2017-9. DMJFY9Z RU https://pubmed.ncbi.nlm.nih.gov/11454470 DMF38M5 DI DMF38M5 DMF38M5 DN 4-Bromo-N-hydroxy-benzamide DMF38M5 MI TT2J34L DMF38M5 MN Arachidonate 5-lipoxygenase (5-LOX) DMF38M5 MT DTT DMF38M5 MA Inhibitor DMF38M5 RN Hydroxamic acid inhibitors of 5-lipoxygenase: quantitative structure-activity relationships. J Med Chem. 1990 Mar;33(3):992-8. DMF38M5 RU https://pubmed.ncbi.nlm.nih.gov/2308149 DM2YN37 DI DM2YN37 DM2YN37 DN 4-bromophenylboronic acid DM2YN37 MI TTUNARX DM2YN37 MN Carbonic anhydrase (CA) DM2YN37 MT DTT DM2YN37 MA Inhibitor DM2YN37 RN Carbonic anhydrase inhibitors. Inhibition of the fungal beta-carbonic anhydrases from Candida albicans and Cryptococcus neoformans with boronic acids. Bioorg Med Chem Lett. 2009 May 15;19(10):2642-5. DM2YN37 RU https://pubmed.ncbi.nlm.nih.gov/19375309 DM2YN37 DI DM2YN37 DM2YN37 DN 4-bromophenylboronic acid DM2YN37 MI TTHQPL7 DM2YN37 MN Carbonic anhydrase I (CA-I) DM2YN37 MT DTT DM2YN37 MA Inhibitor DM2YN37 RN Carbonic anhydrase inhibitors. Inhibition of the fungal beta-carbonic anhydrases from Candida albicans and Cryptococcus neoformans with boronic acids. Bioorg Med Chem Lett. 2009 May 15;19(10):2642-5. DM2YN37 RU https://pubmed.ncbi.nlm.nih.gov/19375309 DM2YN37 DI DM2YN37 DM2YN37 DN 4-bromophenylboronic acid DM2YN37 MI TTANPDJ DM2YN37 MN Carbonic anhydrase II (CA-II) DM2YN37 MT DTT DM2YN37 MA Inhibitor DM2YN37 RN Carbonic anhydrase inhibitors. Inhibition of the fungal beta-carbonic anhydrases from Candida albicans and Cryptococcus neoformans with boronic acids. Bioorg Med Chem Lett. 2009 May 15;19(10):2642-5. DM2YN37 RU https://pubmed.ncbi.nlm.nih.gov/19375309 DMMGK2B DI DMMGK2B DMMGK2B DN 4-Butoxy-N-hydroxycarbamoylmethyl-benzamide DMMGK2B MI TTMX39J DMMGK2B MN Matrix metalloproteinase-1 (MMP-1) DMMGK2B MT DTT DMMGK2B MA Inhibitor DMMGK2B RN Receptor flexibility in de novo ligand design and docking. J Med Chem. 2005 Oct 20;48(21):6585-96. DMMGK2B RU https://pubmed.ncbi.nlm.nih.gov/16220975 DMFCB7L DI DMFCB7L DMFCB7L DN 4-Butoxy-N-hydroxy-N-methyl-benzamide DMFCB7L MI TT2J34L DMFCB7L MN Arachidonate 5-lipoxygenase (5-LOX) DMFCB7L MT DTT DMFCB7L MA Inhibitor DMFCB7L RN Hydroxamic acid inhibitors of 5-lipoxygenase: quantitative structure-activity relationships. J Med Chem. 1990 Mar;33(3):992-8. DMFCB7L RU https://pubmed.ncbi.nlm.nih.gov/2308149 DM6ADJM DI DM6ADJM DM6ADJM DN 4-Butyl-1-[3-(phenylpropoxy)propyl]piperidine DM6ADJM MI TT9JNIC DM6ADJM MN Histamine H3 receptor (H3R) DM6ADJM MT DTT DM6ADJM MA Inhibitor DM6ADJM RN Piperidine variations in search for non-imidazole histamine H(3) receptor ligands. Bioorg Med Chem. 2008 Sep 15;16(18):8729-36. DM6ADJM RU https://pubmed.ncbi.nlm.nih.gov/18774720 DMZHGP6 DI DMZHGP6 DMZHGP6 DN 4-butyl-N-(7-hydroxynaphthalen-1-yl)benzamide DMZHGP6 MI TTMI6F5 DMZHGP6 MN Transient receptor potential cation channel V1 (TRPV1) DMZHGP6 MT DTT DMZHGP6 MA Inhibitor DMZHGP6 RN N-pyridin-3-yl- and N-quinolin-3-yl-benzamides: modulators of human vanilloid receptor 1 (TRPV1). Bioorg Med Chem Lett. 2008 Apr 15;18(8):2730-4. DMZHGP6 RU https://pubmed.ncbi.nlm.nih.gov/18359227 DMHLQSE DI DMHLQSE DMHLQSE DN 4-butyl-N-(isoquinolin-5-yl)benzamide DMHLQSE MI TTMI6F5 DMHLQSE MN Transient receptor potential cation channel V1 (TRPV1) DMHLQSE MT DTT DMHLQSE MA Inhibitor DMHLQSE RN N-pyridin-3-yl- and N-quinolin-3-yl-benzamides: modulators of human vanilloid receptor 1 (TRPV1). Bioorg Med Chem Lett. 2008 Apr 15;18(8):2730-4. DMHLQSE RU https://pubmed.ncbi.nlm.nih.gov/18359227 DMGW9XJ DI DMGW9XJ DMGW9XJ DN 4-butyl-N-(pyridin-3-yl)benzamide DMGW9XJ MI TTMI6F5 DMGW9XJ MN Transient receptor potential cation channel V1 (TRPV1) DMGW9XJ MT DTT DMGW9XJ MA Inhibitor DMGW9XJ RN N-pyridin-3-yl- and N-quinolin-3-yl-benzamides: modulators of human vanilloid receptor 1 (TRPV1). Bioorg Med Chem Lett. 2008 Apr 15;18(8):2730-4. DMGW9XJ RU https://pubmed.ncbi.nlm.nih.gov/18359227 DMRMGWF DI DMRMGWF DMRMGWF DN 4-butyl-N-(quinolin-3-yl)benzamide DMRMGWF MI TTMI6F5 DMRMGWF MN Transient receptor potential cation channel V1 (TRPV1) DMRMGWF MT DTT DMRMGWF MA Inhibitor DMRMGWF RN N-pyridin-3-yl- and N-quinolin-3-yl-benzamides: modulators of human vanilloid receptor 1 (TRPV1). Bioorg Med Chem Lett. 2008 Apr 15;18(8):2730-4. DMRMGWF RU https://pubmed.ncbi.nlm.nih.gov/18359227 DMIMW1E DI DMIMW1E DMIMW1E DN 4-butyl-N-phenylbenzamide DMIMW1E MI TTMI6F5 DMIMW1E MN Transient receptor potential cation channel V1 (TRPV1) DMIMW1E MT DTT DMIMW1E MA Inhibitor DMIMW1E RN N-pyridin-3-yl- and N-quinolin-3-yl-benzamides: modulators of human vanilloid receptor 1 (TRPV1). Bioorg Med Chem Lett. 2008 Apr 15;18(8):2730-4. DMIMW1E RU https://pubmed.ncbi.nlm.nih.gov/18359227 DMD9FZW DI DMD9FZW DMD9FZW DN 4-butylphenylboronic acid DMD9FZW MI TTUNARX DMD9FZW MN Carbonic anhydrase (CA) DMD9FZW MT DTT DMD9FZW MA Inhibitor DMD9FZW RN Carbonic anhydrase inhibitors. Inhibition of the fungal beta-carbonic anhydrases from Candida albicans and Cryptococcus neoformans with boronic acids. Bioorg Med Chem Lett. 2009 May 15;19(10):2642-5. DMD9FZW RU https://pubmed.ncbi.nlm.nih.gov/19375309 DMD9FZW DI DMD9FZW DMD9FZW DN 4-butylphenylboronic acid DMD9FZW MI TTHQPL7 DMD9FZW MN Carbonic anhydrase I (CA-I) DMD9FZW MT DTT DMD9FZW MA Inhibitor DMD9FZW RN Carbonic anhydrase inhibitors. Inhibition of the fungal beta-carbonic anhydrases from Candida albicans and Cryptococcus neoformans with boronic acids. Bioorg Med Chem Lett. 2009 May 15;19(10):2642-5. DMD9FZW RU https://pubmed.ncbi.nlm.nih.gov/19375309 DMD9FZW DI DMD9FZW DMD9FZW DN 4-butylphenylboronic acid DMD9FZW MI TTANPDJ DMD9FZW MN Carbonic anhydrase II (CA-II) DMD9FZW MT DTT DMD9FZW MA Inhibitor DMD9FZW RN Carbonic anhydrase inhibitors. Inhibition of the fungal beta-carbonic anhydrases from Candida albicans and Cryptococcus neoformans with boronic acids. Bioorg Med Chem Lett. 2009 May 15;19(10):2642-5. DMD9FZW RU https://pubmed.ncbi.nlm.nih.gov/19375309 DMKU4TR DI DMKU4TR DMKU4TR DN 4-Butyl-thiazolidin-(2E)-ylideneamine DMKU4TR MI TTZUFI5 DMKU4TR MN Nitric-oxide synthase brain (NOS1) DMKU4TR MT DTT DMKU4TR MA Inhibitor DMKU4TR RN Evaluation of pyrrolidin-2-imines and 1,3-thiazolidin-2-imines as inhibitors of nitric oxide synthase. Bioorg Med Chem Lett. 2004 Sep 6;14(17):4539-44. DMKU4TR RU https://pubmed.ncbi.nlm.nih.gov/15357988 DMKU4TR DI DMKU4TR DMKU4TR DN 4-Butyl-thiazolidin-(2E)-ylideneamine DMKU4TR MI TTF10I9 DMKU4TR MN Nitric-oxide synthase inducible (NOS2) DMKU4TR MT DTT DMKU4TR MA Inhibitor DMKU4TR RN Evaluation of pyrrolidin-2-imines and 1,3-thiazolidin-2-imines as inhibitors of nitric oxide synthase. Bioorg Med Chem Lett. 2004 Sep 6;14(17):4539-44. DMKU4TR RU https://pubmed.ncbi.nlm.nih.gov/15357988 DMRY6B4 DI DMRY6B4 DMRY6B4 DN 4-Butyrylamino-N-hydroxy-benzamide DMRY6B4 MI TTBH0VX DMRY6B4 MN Histone deacetylase (HDAC) DMRY6B4 MT DTT DMRY6B4 MA Inhibitor DMRY6B4 RN Zn2+-chelating motif-tethered short-chain fatty acids as a novel class of histone deacetylase inhibitors. J Med Chem. 2004 Jan 15;47(2):467-74. DMRY6B4 RU https://pubmed.ncbi.nlm.nih.gov/14711316 DMRY6B4 DI DMRY6B4 DMRY6B4 DN 4-Butyrylamino-N-hydroxy-benzamide DMRY6B4 MI TT6R7JZ DMRY6B4 MN Histone deacetylase 1 (HDAC1) DMRY6B4 MT DTT DMRY6B4 MA Inhibitor DMRY6B4 RN Zn2+-chelating motif-tethered short-chain fatty acids as a novel class of histone deacetylase inhibitors. J Med Chem. 2004 Jan 15;47(2):467-74. DMRY6B4 RU https://pubmed.ncbi.nlm.nih.gov/14711316 DMRY6B4 DI DMRY6B4 DMRY6B4 DN 4-Butyrylamino-N-hydroxy-benzamide DMRY6B4 MI TTYHPU6 DMRY6B4 MN Histone deacetylase 10 (HDAC10) DMRY6B4 MT DTT DMRY6B4 MA Inhibitor DMRY6B4 RN Zn2+-chelating motif-tethered short-chain fatty acids as a novel class of histone deacetylase inhibitors. J Med Chem. 2004 Jan 15;47(2):467-74. DMRY6B4 RU https://pubmed.ncbi.nlm.nih.gov/14711316 DMRY6B4 DI DMRY6B4 DMRY6B4 DN 4-Butyrylamino-N-hydroxy-benzamide DMRY6B4 MI TTSHTOI DMRY6B4 MN Histone deacetylase 2 (HDAC2) DMRY6B4 MT DTT DMRY6B4 MA Inhibitor DMRY6B4 RN Zn2+-chelating motif-tethered short-chain fatty acids as a novel class of histone deacetylase inhibitors. J Med Chem. 2004 Jan 15;47(2):467-74. DMRY6B4 RU https://pubmed.ncbi.nlm.nih.gov/14711316 DMRY6B4 DI DMRY6B4 DMRY6B4 DN 4-Butyrylamino-N-hydroxy-benzamide DMRY6B4 MI TTTQGH8 DMRY6B4 MN Histone deacetylase 4 (HDAC4) DMRY6B4 MT DTT DMRY6B4 MA Inhibitor DMRY6B4 RN Zn2+-chelating motif-tethered short-chain fatty acids as a novel class of histone deacetylase inhibitors. J Med Chem. 2004 Jan 15;47(2):467-74. DMRY6B4 RU https://pubmed.ncbi.nlm.nih.gov/14711316 DMRY6B4 DI DMRY6B4 DMRY6B4 DN 4-Butyrylamino-N-hydroxy-benzamide DMRY6B4 MI TT5ZKDI DMRY6B4 MN Histone deacetylase 6 (HDAC6) DMRY6B4 MT DTT DMRY6B4 MA Inhibitor DMRY6B4 RN Zn2+-chelating motif-tethered short-chain fatty acids as a novel class of histone deacetylase inhibitors. J Med Chem. 2004 Jan 15;47(2):467-74. DMRY6B4 RU https://pubmed.ncbi.nlm.nih.gov/14711316 DMRY6B4 DI DMRY6B4 DMRY6B4 DN 4-Butyrylamino-N-hydroxy-benzamide DMRY6B4 MI TTT6LFV DMRY6B4 MN Histone deacetylase 8 (HDAC8) DMRY6B4 MT DTT DMRY6B4 MA Inhibitor DMRY6B4 RN Zn2+-chelating motif-tethered short-chain fatty acids as a novel class of histone deacetylase inhibitors. J Med Chem. 2004 Jan 15;47(2):467-74. DMRY6B4 RU https://pubmed.ncbi.nlm.nih.gov/14711316 DM74GWO DI DM74GWO DM74GWO DN 4-Carbazol-9-yl-butyric acid DM74GWO MI TTHWMFZ DM74GWO MN Fatty acid-binding protein 4 (FABP4) DM74GWO MT DTT DM74GWO MA Inhibitor DM74GWO RN Discovery of inhibitors of human adipocyte fatty acid-binding protein, a potential type 2 diabetes target. Bioorg Med Chem Lett. 2004 Sep 6;14(17):4445-8. DM74GWO RU https://pubmed.ncbi.nlm.nih.gov/15357969 DM74GWO DI DM74GWO DM74GWO DN 4-Carbazol-9-yl-butyric acid DM74GWO MI TTNT2S6 DM74GWO MN Fatty acid-binding protein 5 (FABP5) DM74GWO MT DTT DM74GWO MA Inhibitor DM74GWO RN Discovery of inhibitors of human adipocyte fatty acid-binding protein, a potential type 2 diabetes target. Bioorg Med Chem Lett. 2004 Sep 6;14(17):4445-8. DM74GWO RU https://pubmed.ncbi.nlm.nih.gov/15357969 DMBIQV3 DI DMBIQV3 DMBIQV3 DN 4-Carboxycinnamic Acid DMBIQV3 MI TTQO71U DMBIQV3 MN Hemoglobin (HB) DMBIQV3 MT DTT DMBIQV3 MA Inhibitor DMBIQV3 RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DMBIQV3 RU https://pubmed.ncbi.nlm.nih.gov/10592235 DM8A2QO DI DM8A2QO DM8A2QO DN 4-Carboxyphenylboronic Acid DM8A2QO MI TTHI19T DM8A2QO MN Staphylococcus Beta-lactamase (Stap-coc blaZ) DM8A2QO MT DTT DM8A2QO MA Inhibitor DM8A2QO RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DM8A2QO RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMMIA36 DI DMMIA36 DMMIA36 DN 4-chloro-1-guanidino-7-isoquinolinesulphonamide DMMIA36 MI TTGY7WI DMMIA36 MN Urokinase-type plasminogen activator (PLAU) DMMIA36 MT DTT DMMIA36 MA Inhibitor DMMIA36 RN Selective urokinase-type plasminogen activator inhibitors. 4. 1-(7-sulfonamidoisoquinolinyl)guanidines. J Med Chem. 2007 May 17;50(10):2341-51. DMMIA36 RU https://pubmed.ncbi.nlm.nih.gov/17447747 DMHNSXP DI DMHNSXP DMHNSXP DN 4-chloro-1H-indazole DMHNSXP MI TTZUFI5 DMHNSXP MN Nitric-oxide synthase brain (NOS1) DMHNSXP MT DTT DMHNSXP MA Inhibitor DMHNSXP RN 4-substituted indazoles as new inhibitors of neuronal nitric oxide synthase. Bioorg Med Chem Lett. 2007 Jun 1;17(11):3177-80. DMHNSXP RU https://pubmed.ncbi.nlm.nih.gov/17395463 DM9HXPR DI DM9HXPR DM9HXPR DN 4-chloro-1H-indole-2,3-dione DM9HXPR MI TTMF541 DM9HXPR MN Liver carboxylesterase (CES1) DM9HXPR MT DTT DM9HXPR MA Inhibitor DM9HXPR RN Selective inhibition of carboxylesterases by isatins, indole-2,3-diones. J Med Chem. 2007 Apr 19;50(8):1876-85. DM9HXPR RU https://pubmed.ncbi.nlm.nih.gov/17378546 DMKJ18X DI DMKJ18X DMKJ18X DN 4-Chloro-2-(4-hydroxy-phenyl)-quinolin-6-ol DMKJ18X MI TTZAYWL DMKJ18X MN Estrogen receptor (ESR) DMKJ18X MT DTT DMKJ18X MA Inhibitor DMKJ18X RN ERbeta ligands. Part 4: Synthesis and structure-activity relationships of a series of 2-phenylquinoline derivatives. Bioorg Med Chem Lett. 2005 Oct 15;15(20):4520-5. DMKJ18X RU https://pubmed.ncbi.nlm.nih.gov/16098741 DMKJ18X DI DMKJ18X DMKJ18X DN 4-Chloro-2-(4-hydroxy-phenyl)-quinolin-6-ol DMKJ18X MI TTOM3J0 DMKJ18X MN Estrogen receptor beta (ESR2) DMKJ18X MT DTT DMKJ18X MA Inhibitor DMKJ18X RN ERbeta ligands. Part 4: Synthesis and structure-activity relationships of a series of 2-phenylquinoline derivatives. Bioorg Med Chem Lett. 2005 Oct 15;15(20):4520-5. DMKJ18X RU https://pubmed.ncbi.nlm.nih.gov/16098741 DMKJ18X DI DMKJ18X DMKJ18X DN 4-Chloro-2-(4-hydroxy-phenyl)-quinolin-6-ol DMKJ18X MI TTPNQAC DMKJ18X MN Estrogen-related receptor-alpha (ESRRA) DMKJ18X MT DTT DMKJ18X MA Inhibitor DMKJ18X RN ERbeta ligands. Part 6: 6H-Chromeno[4,3-b]quinolines as a new series of estrogen receptor beta-selective ligands. Bioorg Med Chem Lett. 2007 Jul 15;17(14):4053-6. DMKJ18X RU https://pubmed.ncbi.nlm.nih.gov/17482813 DM9VN21 DI DM9VN21 DM9VN21 DN 4-Chloro-2,6-diisopropyl-phenol DM9VN21 MI TTNJYV2 DM9VN21 MN Gamma-aminobutyric acid receptor (GAR) DM9VN21 MT DTT DM9VN21 MA Inhibitor DM9VN21 RN Propofol analogues. Synthesis, relationships between structure and affinity at GABAA receptor in rat brain, and differential electrophysiological p... J Med Chem. 1998 May 21;41(11):1846-54. DM9VN21 RU https://pubmed.ncbi.nlm.nih.gov/9599235 DMIYVJX DI DMIYVJX DMIYVJX DN 4-CHLORO-3',3''-DIBROMOPHENOL-1,8-NAPHTHALEIN DMIYVJX MI TTU6BFZ DMIYVJX MN Candida Thymidylate synthase (Candi TMP1) DMIYVJX MT DTT DMIYVJX MA Inhibitor DMIYVJX RN DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Nucleic Acids Res. 2011 Jan;39(Database issue):D1035-41. DMIYVJX RU https://pubmed.ncbi.nlm.nih.gov/21059682 DMMALY3 DI DMMALY3 DMMALY3 DN 4-Chloro-3-hydroxy-1H-quinolin-2-one DMMALY3 MI TTLD29N DMMALY3 MN Glutamate receptor ionotropic NMDA 1 (NMDAR1) DMMALY3 MT DTT DMMALY3 MA Inhibitor DMMALY3 RN 3-Hydroxy-quinolin-2-ones: Inhibitors of [3H]-glycine binding to the site associated with the NMDA receptor, Bioorg. Med. Chem. Lett. 6(5):499-504 (1996). DMMALY3 RU http://www.sciencedirect.com/science/article/pii/0960894X96000315 DMMALY3 DI DMMALY3 DMMALY3 DN 4-Chloro-3-hydroxy-1H-quinolin-2-one DMMALY3 MI TTKJEMQ DMMALY3 MN Glutamate receptor ionotropic NMDA 2A (NMDAR2A) DMMALY3 MT DTT DMMALY3 MA Inhibitor DMMALY3 RN 3-Hydroxy-quinolin-2-ones: Inhibitors of [3H]-glycine binding to the site associated with the NMDA receptor, Bioorg. Med. Chem. Lett. 6(5):499-504 (1996). DMMALY3 RU http://www.sciencedirect.com/science/article/pii/0960894X96000315 DMMALY3 DI DMMALY3 DMMALY3 DN 4-Chloro-3-hydroxy-1H-quinolin-2-one DMMALY3 MI TTN9D8E DMMALY3 MN Glutamate receptor ionotropic NMDA 2B (NMDAR2B) DMMALY3 MT DTT DMMALY3 MA Inhibitor DMMALY3 RN 3-Hydroxy-quinolin-2-ones: Inhibitors of [3H]-glycine binding to the site associated with the NMDA receptor, Bioorg. Med. Chem. Lett. 6(5):499-504 (1996). DMMALY3 RU http://www.sciencedirect.com/science/article/pii/0960894X96000315 DMI580M DI DMI580M DMI580M DN 4-Chloro-5,7-diphenyl-7H-pyrrolo[2,3-d]pyrimidine DMI580M MI TT6PKBN DMI580M MN Proto-oncogene c-Src (SRC) DMI580M MT DTT DMI580M MA Inhibitor DMI580M RN Substituted 5,7-diphenyl-pyrrolo[2,3d]pyrimidines: potent inhibitors of the tyrosine kinase c-Src. Bioorg Med Chem Lett. 2000 May 1;10(9):945-9. DMI580M RU https://pubmed.ncbi.nlm.nih.gov/10853665 DM04OFE DI DM04OFE DM04OFE DN 4-Chloro-6-nitro-2-piperazin-1-yl-quinoline DM04OFE MI TT3ROYC DM04OFE MN Serotonin transporter (SERT) DM04OFE MT DTT DM04OFE MA Inhibitor DM04OFE RN Syntheses and binding affinities of 6-nitroquipazine analogues for serotonin transporter. Part 2: 4-substituted 6-nitroquipazines. Bioorg Med Chem Lett. 2002 Mar 11;12(5):811-5. DM04OFE RU https://pubmed.ncbi.nlm.nih.gov/11859009 DM16P3N DI DM16P3N DM16P3N DN 4-chloro-7-methyl-1H-indole-2,3-dione DM16P3N MI TTMF541 DM16P3N MN Liver carboxylesterase (CES1) DM16P3N MT DTT DM16P3N MA Inhibitor DM16P3N RN Selective inhibition of carboxylesterases by isatins, indole-2,3-diones. J Med Chem. 2007 Apr 19;50(8):1876-85. DM16P3N RU https://pubmed.ncbi.nlm.nih.gov/17378546 DM9SVEB DI DM9SVEB DM9SVEB DN 4-Chloro-7-methyl-2-phenyl-[1,8]naphthyridine DM9SVEB MI TTK25J1 DM9SVEB MN Adenosine A1 receptor (ADORA1) DM9SVEB MT DTT DM9SVEB MA Inhibitor DM9SVEB RN A novel class of highly potent and selective A1 adenosine antagonists: structure-affinity profile of a series of 1,8-naphthyridine derivatives. J Med Chem. 2000 Jul 27;43(15):2814-23. DM9SVEB RU https://pubmed.ncbi.nlm.nih.gov/10956189 DMKTSPM DI DMKTSPM DMKTSPM DN 4-Chlorobenzenemethanethiol DMKTSPM MI TTZJYKH DMKTSPM MN Indoleamine 2,3-dioxygenase 1 (IDO1) DMKTSPM MT DTT DMKTSPM MA Inhibitor DMKTSPM RN S-benzylisothiourea derivatives as small-molecule inhibitors of indoleamine-2,3-dioxygenase. Bioorg Med Chem Lett. 2010 Sep 1;20(17):5126-9. DMKTSPM RU https://pubmed.ncbi.nlm.nih.gov/20688518 DMHL9V3 DI DMHL9V3 DMHL9V3 DN 4-chloro-N-(2,5-dichlorophenyl)-3-nitrobenzamide DMHL9V3 MI TTVTX4N DMHL9V3 MN Bacterial Fatty acid synthetase I (Bact inhA) DMHL9V3 MT DTT DMHL9V3 MA Inhibitor DMHL9V3 RN Discovery of potential new InhA direct inhibitors based on pharmacophore and 3D-QSAR analysis followed by in silico screening. Eur J Med Chem. 2009 Sep;44(9):3718-30. DMHL9V3 RU https://pubmed.ncbi.nlm.nih.gov/19428156 DMVJ61A DI DMVJ61A DMVJ61A DN 4-Chloro-N-(2-chloro-benzoyl)-benzenesulfonamide DMVJ61A MI TTUTJGQ DMVJ61A MN Vascular endothelial growth factor receptor 2 (KDR) DMVJ61A MT DTT DMVJ61A MA Inhibitor DMVJ61A RN Acyl sulfonamide anti-proliferatives: benzene substituent structure-activity relationships for a novel class of antitumor agents. J Med Chem. 2004 Oct 21;47(22):5367-80. DMVJ61A RU https://pubmed.ncbi.nlm.nih.gov/15481975 DMVJ61A DI DMVJ61A DMVJ61A DN 4-Chloro-N-(2-chloro-benzoyl)-benzenesulfonamide DMVJ61A MI TTDCBX5 DMVJ61A MN Vascular endothelial growth factor receptor 3 (FLT-4) DMVJ61A MT DTT DMVJ61A MA Inhibitor DMVJ61A RN Acyl sulfonamide anti-proliferatives: benzene substituent structure-activity relationships for a novel class of antitumor agents. J Med Chem. 2004 Oct 21;47(22):5367-80. DMVJ61A RU https://pubmed.ncbi.nlm.nih.gov/15481975 DMVJ61A DI DMVJ61A DMVJ61A DN 4-Chloro-N-(2-chloro-benzoyl)-benzenesulfonamide DMVJ61A MI TT1VAUK DMVJ61A MN VEGFR1 messenger RNA (VEGFR1 mRNA) DMVJ61A MT DTT DMVJ61A MA Inhibitor DMVJ61A RN Acyl sulfonamide anti-proliferatives: benzene substituent structure-activity relationships for a novel class of antitumor agents. J Med Chem. 2004 Oct 21;47(22):5367-80. DMVJ61A RU https://pubmed.ncbi.nlm.nih.gov/15481975 DM6SI78 DI DM6SI78 DM6SI78 DN 4-Chloro-N-(2-methyl-benzoyl)-benzenesulfonamide DM6SI78 MI TTUTJGQ DM6SI78 MN Vascular endothelial growth factor receptor 2 (KDR) DM6SI78 MT DTT DM6SI78 MA Inhibitor DM6SI78 RN Acyl sulfonamide anti-proliferatives: benzene substituent structure-activity relationships for a novel class of antitumor agents. J Med Chem. 2004 Oct 21;47(22):5367-80. DM6SI78 RU https://pubmed.ncbi.nlm.nih.gov/15481975 DM6SI78 DI DM6SI78 DM6SI78 DN 4-Chloro-N-(2-methyl-benzoyl)-benzenesulfonamide DM6SI78 MI TTDCBX5 DM6SI78 MN Vascular endothelial growth factor receptor 3 (FLT-4) DM6SI78 MT DTT DM6SI78 MA Inhibitor DM6SI78 RN Acyl sulfonamide anti-proliferatives: benzene substituent structure-activity relationships for a novel class of antitumor agents. J Med Chem. 2004 Oct 21;47(22):5367-80. DM6SI78 RU https://pubmed.ncbi.nlm.nih.gov/15481975 DM6SI78 DI DM6SI78 DM6SI78 DN 4-Chloro-N-(2-methyl-benzoyl)-benzenesulfonamide DM6SI78 MI TT1VAUK DM6SI78 MN VEGFR1 messenger RNA (VEGFR1 mRNA) DM6SI78 MT DTT DM6SI78 MA Inhibitor DM6SI78 RN Acyl sulfonamide anti-proliferatives: benzene substituent structure-activity relationships for a novel class of antitumor agents. J Med Chem. 2004 Oct 21;47(22):5367-80. DM6SI78 RU https://pubmed.ncbi.nlm.nih.gov/15481975 DMVCLP8 DI DMVCLP8 DMVCLP8 DN 4-Chloro-N-(2-morpholinoethyl)nicotinamide DMVCLP8 MI TT3WG5C DMVCLP8 MN Monoamine oxidase type A (MAO-A) DMVCLP8 MT DTT DMVCLP8 MA Inhibitor DMVCLP8 RN Design of novel nicotinamides as potent and selective monoamine oxidase a inhibitors. Bioorg Med Chem. 2010 Feb 15;18(4):1659-64. DMVCLP8 RU https://pubmed.ncbi.nlm.nih.gov/20117937 DMI3OR9 DI DMI3OR9 DMI3OR9 DN 4-Chloro-N-(3-chloro-benzoyl)-benzenesulfonamide DMI3OR9 MI TTUTJGQ DMI3OR9 MN Vascular endothelial growth factor receptor 2 (KDR) DMI3OR9 MT DTT DMI3OR9 MA Inhibitor DMI3OR9 RN Acyl sulfonamide anti-proliferatives: benzene substituent structure-activity relationships for a novel class of antitumor agents. J Med Chem. 2004 Oct 21;47(22):5367-80. DMI3OR9 RU https://pubmed.ncbi.nlm.nih.gov/15481975 DMI3OR9 DI DMI3OR9 DMI3OR9 DN 4-Chloro-N-(3-chloro-benzoyl)-benzenesulfonamide DMI3OR9 MI TTDCBX5 DMI3OR9 MN Vascular endothelial growth factor receptor 3 (FLT-4) DMI3OR9 MT DTT DMI3OR9 MA Inhibitor DMI3OR9 RN Acyl sulfonamide anti-proliferatives: benzene substituent structure-activity relationships for a novel class of antitumor agents. J Med Chem. 2004 Oct 21;47(22):5367-80. DMI3OR9 RU https://pubmed.ncbi.nlm.nih.gov/15481975 DMI3OR9 DI DMI3OR9 DMI3OR9 DN 4-Chloro-N-(3-chloro-benzoyl)-benzenesulfonamide DMI3OR9 MI TT1VAUK DMI3OR9 MN VEGFR1 messenger RNA (VEGFR1 mRNA) DMI3OR9 MT DTT DMI3OR9 MA Inhibitor DMI3OR9 RN Acyl sulfonamide anti-proliferatives: benzene substituent structure-activity relationships for a novel class of antitumor agents. J Med Chem. 2004 Oct 21;47(22):5367-80. DMI3OR9 RU https://pubmed.ncbi.nlm.nih.gov/15481975 DMM8G6H DI DMM8G6H DMM8G6H DN 4-Chloro-N-(3-morpholinopropyl)nicotinamide DMM8G6H MI TT3WG5C DMM8G6H MN Monoamine oxidase type A (MAO-A) DMM8G6H MT DTT DMM8G6H MA Inhibitor DMM8G6H RN Design of novel nicotinamides as potent and selective monoamine oxidase a inhibitors. Bioorg Med Chem. 2010 Feb 15;18(4):1659-64. DMM8G6H RU https://pubmed.ncbi.nlm.nih.gov/20117937 DMTDX2S DI DMTDX2S DMTDX2S DN 4-Chloro-N-(4-chloro-benzoyl)-benzenesulfonamide DMTDX2S MI TTUTJGQ DMTDX2S MN Vascular endothelial growth factor receptor 2 (KDR) DMTDX2S MT DTT DMTDX2S MA Inhibitor DMTDX2S RN Acyl sulfonamide anti-proliferatives: benzene substituent structure-activity relationships for a novel class of antitumor agents. J Med Chem. 2004 Oct 21;47(22):5367-80. DMTDX2S RU https://pubmed.ncbi.nlm.nih.gov/15481975 DMTDX2S DI DMTDX2S DMTDX2S DN 4-Chloro-N-(4-chloro-benzoyl)-benzenesulfonamide DMTDX2S MI TTDCBX5 DMTDX2S MN Vascular endothelial growth factor receptor 3 (FLT-4) DMTDX2S MT DTT DMTDX2S MA Inhibitor DMTDX2S RN Acyl sulfonamide anti-proliferatives: benzene substituent structure-activity relationships for a novel class of antitumor agents. J Med Chem. 2004 Oct 21;47(22):5367-80. DMTDX2S RU https://pubmed.ncbi.nlm.nih.gov/15481975 DMTDX2S DI DMTDX2S DMTDX2S DN 4-Chloro-N-(4-chloro-benzoyl)-benzenesulfonamide DMTDX2S MI TT1VAUK DMTDX2S MN VEGFR1 messenger RNA (VEGFR1 mRNA) DMTDX2S MT DTT DMTDX2S MA Inhibitor DMTDX2S RN Acyl sulfonamide anti-proliferatives: benzene substituent structure-activity relationships for a novel class of antitumor agents. J Med Chem. 2004 Oct 21;47(22):5367-80. DMTDX2S RU https://pubmed.ncbi.nlm.nih.gov/15481975 DMM0TL6 DI DMM0TL6 DMM0TL6 DN 4-Chloro-N-(4-nitro-benzoyl)-benzenesulfonamide DMM0TL6 MI TTUTJGQ DMM0TL6 MN Vascular endothelial growth factor receptor 2 (KDR) DMM0TL6 MT DTT DMM0TL6 MA Inhibitor DMM0TL6 RN Acyl sulfonamide anti-proliferatives: benzene substituent structure-activity relationships for a novel class of antitumor agents. J Med Chem. 2004 Oct 21;47(22):5367-80. DMM0TL6 RU https://pubmed.ncbi.nlm.nih.gov/15481975 DMM0TL6 DI DMM0TL6 DMM0TL6 DN 4-Chloro-N-(4-nitro-benzoyl)-benzenesulfonamide DMM0TL6 MI TTDCBX5 DMM0TL6 MN Vascular endothelial growth factor receptor 3 (FLT-4) DMM0TL6 MT DTT DMM0TL6 MA Inhibitor DMM0TL6 RN Acyl sulfonamide anti-proliferatives: benzene substituent structure-activity relationships for a novel class of antitumor agents. J Med Chem. 2004 Oct 21;47(22):5367-80. DMM0TL6 RU https://pubmed.ncbi.nlm.nih.gov/15481975 DMM0TL6 DI DMM0TL6 DMM0TL6 DN 4-Chloro-N-(4-nitro-benzoyl)-benzenesulfonamide DMM0TL6 MI TT1VAUK DMM0TL6 MN VEGFR1 messenger RNA (VEGFR1 mRNA) DMM0TL6 MT DTT DMM0TL6 MA Inhibitor DMM0TL6 RN Acyl sulfonamide anti-proliferatives: benzene substituent structure-activity relationships for a novel class of antitumor agents. J Med Chem. 2004 Oct 21;47(22):5367-80. DMM0TL6 RU https://pubmed.ncbi.nlm.nih.gov/15481975 DMVKU4L DI DMVKU4L DMVKU4L DN 4-Chloro-N-(4-phenyl-thiazol-2-yl)-benzamide DMVKU4L MI TTK25J1 DMVKU4L MN Adenosine A1 receptor (ADORA1) DMVKU4L MT DTT DMVKU4L MA Inhibitor DMVKU4L RN Substituted 4-phenyl-2-(phenylcarboxamido)-1,3-thiazole derivatives as antagonists for the adenosine A(1) receptor. Bioorg Med Chem Lett. 2001 Aug 6;11(15):2017-9. DMVKU4L RU https://pubmed.ncbi.nlm.nih.gov/11454470 DM5AVG3 DI DM5AVG3 DM5AVG3 DN 4-Chloro-N-(5-hydroxycarbamoyl-pentyl)-benzamide DM5AVG3 MI TTBH0VX DM5AVG3 MN Histone deacetylase (HDAC) DM5AVG3 MT DTT DM5AVG3 MA Inhibitor DM5AVG3 RN Inhibitors of human histone deacetylase: synthesis and enzyme and cellular activity of straight chain hydroxamates. J Med Chem. 2002 Feb 14;45(4):753-7. DM5AVG3 RU https://pubmed.ncbi.nlm.nih.gov/11831887 DM5AVG3 DI DM5AVG3 DM5AVG3 DN 4-Chloro-N-(5-hydroxycarbamoyl-pentyl)-benzamide DM5AVG3 MI TT6R7JZ DM5AVG3 MN Histone deacetylase 1 (HDAC1) DM5AVG3 MT DTT DM5AVG3 MA Inhibitor DM5AVG3 RN Histone deacetylase inhibitors. J Med Chem. 2003 Nov 20;46(24):5097-116. DM5AVG3 RU https://pubmed.ncbi.nlm.nih.gov/14613312 DM5AVG3 DI DM5AVG3 DM5AVG3 DN 4-Chloro-N-(5-hydroxycarbamoyl-pentyl)-benzamide DM5AVG3 MI TTYHPU6 DM5AVG3 MN Histone deacetylase 10 (HDAC10) DM5AVG3 MT DTT DM5AVG3 MA Inhibitor DM5AVG3 RN Inhibitors of human histone deacetylase: synthesis and enzyme and cellular activity of straight chain hydroxamates. J Med Chem. 2002 Feb 14;45(4):753-7. DM5AVG3 RU https://pubmed.ncbi.nlm.nih.gov/11831887 DM5AVG3 DI DM5AVG3 DM5AVG3 DN 4-Chloro-N-(5-hydroxycarbamoyl-pentyl)-benzamide DM5AVG3 MI TTSHTOI DM5AVG3 MN Histone deacetylase 2 (HDAC2) DM5AVG3 MT DTT DM5AVG3 MA Inhibitor DM5AVG3 RN Histone deacetylase inhibitors. J Med Chem. 2003 Nov 20;46(24):5097-116. DM5AVG3 RU https://pubmed.ncbi.nlm.nih.gov/14613312 DM5AVG3 DI DM5AVG3 DM5AVG3 DN 4-Chloro-N-(5-hydroxycarbamoyl-pentyl)-benzamide DM5AVG3 MI TTTQGH8 DM5AVG3 MN Histone deacetylase 4 (HDAC4) DM5AVG3 MT DTT DM5AVG3 MA Inhibitor DM5AVG3 RN Histone deacetylase inhibitors. J Med Chem. 2003 Nov 20;46(24):5097-116. DM5AVG3 RU https://pubmed.ncbi.nlm.nih.gov/14613312 DM5AVG3 DI DM5AVG3 DM5AVG3 DN 4-Chloro-N-(5-hydroxycarbamoyl-pentyl)-benzamide DM5AVG3 MI TT5ZKDI DM5AVG3 MN Histone deacetylase 6 (HDAC6) DM5AVG3 MT DTT DM5AVG3 MA Inhibitor DM5AVG3 RN Histone deacetylase inhibitors. J Med Chem. 2003 Nov 20;46(24):5097-116. DM5AVG3 RU https://pubmed.ncbi.nlm.nih.gov/14613312 DM5AVG3 DI DM5AVG3 DM5AVG3 DN 4-Chloro-N-(5-hydroxycarbamoyl-pentyl)-benzamide DM5AVG3 MI TTT6LFV DM5AVG3 MN Histone deacetylase 8 (HDAC8) DM5AVG3 MT DTT DM5AVG3 MA Inhibitor DM5AVG3 RN Inhibitors of human histone deacetylase: synthesis and enzyme and cellular activity of straight chain hydroxamates. J Med Chem. 2002 Feb 14;45(4):753-7. DM5AVG3 RU https://pubmed.ncbi.nlm.nih.gov/11831887 DM2UYCS DI DM2UYCS DM2UYCS DN 4-Chloro-N-(5-sulfamoyl-indan-2-yl)-benzamide DM2UYCS MI TTHQPL7 DM2UYCS MN Carbonic anhydrase I (CA-I) DM2UYCS MT DTT DM2UYCS MA Inhibitor DM2UYCS RN Carbonic anhydrase inhibitors. Design of anticonvulsant sulfonamides incorporating indane moieties. Bioorg Med Chem Lett. 2004 Dec 6;14(23):5781-6. DM2UYCS RU https://pubmed.ncbi.nlm.nih.gov/15501040 DM2UYCS DI DM2UYCS DM2UYCS DN 4-Chloro-N-(5-sulfamoyl-indan-2-yl)-benzamide DM2UYCS MI TTANPDJ DM2UYCS MN Carbonic anhydrase II (CA-II) DM2UYCS MT DTT DM2UYCS MA Inhibitor DM2UYCS RN Carbonic anhydrase inhibitors. Design of anticonvulsant sulfonamides incorporating indane moieties. Bioorg Med Chem Lett. 2004 Dec 6;14(23):5781-6. DM2UYCS RU https://pubmed.ncbi.nlm.nih.gov/15501040 DMPINBR DI DMPINBR DMPINBR DN 4-chlorophenyl 10H-phenothiazine-10-carboxylate DMPINBR MI TTEB0GD DMPINBR MN Cholinesterase (BCHE) DMPINBR MT DTT DMPINBR MA Inhibitor DMPINBR RN Carbamates with differential mechanism of inhibition toward acetylcholinesterase and butyrylcholinesterase. J Med Chem. 2008 Jul 24;51(14):4200-12. DMPINBR RU https://pubmed.ncbi.nlm.nih.gov/18570368 DMWGF9R DI DMWGF9R DMWGF9R DN 4'-cyano-3-(imidazolylmethyl)-7-methoxyflavone DMWGF9R MI TTSZLWK DMWGF9R MN Aromatase (CYP19A1) DMWGF9R MT DTT DMWGF9R MA Inhibitor DMWGF9R RN Lead optimization providing a series of flavone derivatives as potent nonsteroidal inhibitors of the cytochrome P450 aromatase enzyme. J Med Chem. 2006 Jul 27;49(15):4777-80. DMWGF9R RU https://pubmed.ncbi.nlm.nih.gov/16854084 DMUJS4R DI DMUJS4R DMUJS4R DN 4'-cyano-3-(imidazolylmethyl)flavone DMUJS4R MI TTSZLWK DMUJS4R MN Aromatase (CYP19A1) DMUJS4R MT DTT DMUJS4R MA Inhibitor DMUJS4R RN Lead optimization providing a series of flavone derivatives as potent nonsteroidal inhibitors of the cytochrome P450 aromatase enzyme. J Med Chem. 2006 Jul 27;49(15):4777-80. DMUJS4R RU https://pubmed.ncbi.nlm.nih.gov/16854084 DMJ610E DI DMJ610E DMJ610E DN 4-cyano-N-(1,3-diphenyl-1H-pyrazol-5-yl)benzamide DMJ610E MI TTHS256 DMJ610E MN Metabotropic glutamate receptor 5 (mGluR5) DMJ610E MT DTT DMJ610E MA Inhibitor DMJ610E RN Substituent effects of N-(1,3-diphenyl-1H-pyrazol-5-yl)benzamides on positive allosteric modulation of the metabotropic glutamate-5 receptor in rat... J Med Chem. 2006 Jun 1;49(11):3332-44. DMJ610E RU https://pubmed.ncbi.nlm.nih.gov/16722652 DMN12EX DI DMN12EX DMN12EX DN 4-CYANOPHENOL DMN12EX MI TTUNARX DMN12EX MN Carbonic anhydrase (CA) DMN12EX MT DTT DMN12EX MA Inhibitor DMN12EX RN Carbonic anhydrase inhibitors: inhibition of mammalian isoforms I-XIV with a series of substituted phenols including paracetamol and salicylic acid. Bioorg Med Chem. 2008 Aug 1;16(15):7424-8. DMN12EX RU https://pubmed.ncbi.nlm.nih.gov/18579385 DMN12EX DI DMN12EX DMN12EX DN 4-CYANOPHENOL DMN12EX MI TTANPDJ DMN12EX MN Carbonic anhydrase II (CA-II) DMN12EX MT DTT DMN12EX MA Inhibitor DMN12EX RN Carbonic anhydrase inhibitors: inhibition of mammalian isoforms I-XIV with a series of substituted phenols including paracetamol and salicylic acid. Bioorg Med Chem. 2008 Aug 1;16(15):7424-8. DMN12EX RU https://pubmed.ncbi.nlm.nih.gov/18579385 DMN12EX DI DMN12EX DMN12EX DN 4-CYANOPHENOL DMN12EX MI TTCFSPE DMN12EX MN Carbonic anhydrase VI (CA-VI) DMN12EX MT DTT DMN12EX MA Inhibitor DMN12EX RN Carbonic anhydrase inhibitors: inhibition of mammalian isoforms I-XIV with a series of substituted phenols including paracetamol and salicylic acid. Bioorg Med Chem. 2008 Aug 1;16(15):7424-8. DMN12EX RU https://pubmed.ncbi.nlm.nih.gov/18579385 DMN12EX DI DMN12EX DMN12EX DN 4-CYANOPHENOL DMN12EX MI TTSYM0R DMN12EX MN Carbonic anhydrase XII (CA-XII) DMN12EX MT DTT DMN12EX MA Inhibitor DMN12EX RN Carbonic anhydrase inhibitors: inhibition of mammalian isoforms I-XIV with a series of substituted phenols including paracetamol and salicylic acid. Bioorg Med Chem. 2008 Aug 1;16(15):7424-8. DMN12EX RU https://pubmed.ncbi.nlm.nih.gov/18579385 DMEP80Q DI DMEP80Q DMEP80Q DN 4-cyanophenyl ethyl dodecylphosphonate DMEP80Q MI TT6OEDT DMEP80Q MN Cannabinoid receptor 1 (CB1) DMEP80Q MT DTT DMEP80Q MA Inhibitor DMEP80Q RN Monoacylglycerol lipase regulates 2-arachidonoylglycerol action and arachidonic acid levels. Bioorg Med Chem Lett. 2008 Nov 15;18(22):5875-8. DMEP80Q RU https://pubmed.ncbi.nlm.nih.gov/18752948 DMEP80Q DI DMEP80Q DMEP80Q DN 4-cyanophenyl ethyl dodecylphosphonate DMEP80Q MI TTDP1UC DMEP80Q MN Fatty acid amide hydrolase (FAAH) DMEP80Q MT DTT DMEP80Q MA Inhibitor DMEP80Q RN Monoacylglycerol lipase regulates 2-arachidonoylglycerol action and arachidonic acid levels. Bioorg Med Chem Lett. 2008 Nov 15;18(22):5875-8. DMEP80Q RU https://pubmed.ncbi.nlm.nih.gov/18752948 DMOLFHZ DI DMOLFHZ DMOLFHZ DN 4-cyanophenylboronic acid DMOLFHZ MI TTDP1UC DMOLFHZ MN Fatty acid amide hydrolase (FAAH) DMOLFHZ MT DTT DMOLFHZ MA Inhibitor DMOLFHZ RN Discovery of boronic acids as novel and potent inhibitors of fatty acid amide hydrolase. J Med Chem. 2008 Nov 27;51(22):7057-60. DMOLFHZ RU https://pubmed.ncbi.nlm.nih.gov/18983140 DMNT5BF DI DMNT5BF DMNT5BF DN 4-cycloheptyl-6-propylpyrimidine-2-carbonitrile DMNT5BF MI TTDZN01 DMNT5BF MN Cathepsin K (CTSK) DMNT5BF MT DTT DMNT5BF MA Inhibitor DMNT5BF RN Design and optimization of a series of novel 2-cyano-pyrimidines as cathepsin K inhibitors. Bioorg Med Chem Lett. 2010 Mar 1;20(5):1524-7. DMNT5BF RU https://pubmed.ncbi.nlm.nih.gov/20149657 DMNT5BF DI DMNT5BF DMNT5BF DN 4-cycloheptyl-6-propylpyrimidine-2-carbonitrile DMNT5BF MI TTUMQVO DMNT5BF MN Cathepsin S (CTSS) DMNT5BF MT DTT DMNT5BF MA Inhibitor DMNT5BF RN Design and optimization of a series of novel 2-cyano-pyrimidines as cathepsin K inhibitors. Bioorg Med Chem Lett. 2010 Mar 1;20(5):1524-7. DMNT5BF RU https://pubmed.ncbi.nlm.nih.gov/20149657 DM4LIUC DI DM4LIUC DM4LIUC DN 4-cycloheptyliden(4-hydroxyphenyl)methylphenol DM4LIUC MI TTFJ8Q1 DM4LIUC MN Protein kinase C alpha (PRKCA) DM4LIUC MT DTT DM4LIUC MA Inhibitor DM4LIUC RN Multivariate analysis by the minimum spanning tree method of the structural determinants of diphenylethylenes and triphenylacrylonitriles implicate... J Med Chem. 1992 Feb 7;35(3):573-83. DM4LIUC RU https://pubmed.ncbi.nlm.nih.gov/1738150 DM4LIUC DI DM4LIUC DM4LIUC DN 4-cycloheptyliden(4-hydroxyphenyl)methylphenol DM4LIUC MI TTYPXQF DM4LIUC MN Protein kinase C beta (PRKCB) DM4LIUC MT DTT DM4LIUC MA Inhibitor DM4LIUC RN Multivariate analysis by the minimum spanning tree method of the structural determinants of diphenylethylenes and triphenylacrylonitriles implicate... J Med Chem. 1992 Feb 7;35(3):573-83. DM4LIUC RU https://pubmed.ncbi.nlm.nih.gov/1738150 DM4LIUC DI DM4LIUC DM4LIUC DN 4-cycloheptyliden(4-hydroxyphenyl)methylphenol DM4LIUC MI TT9WJ8U DM4LIUC MN Protein kinase C delta (PRKCD) DM4LIUC MT DTT DM4LIUC MA Inhibitor DM4LIUC RN Multivariate analysis by the minimum spanning tree method of the structural determinants of diphenylethylenes and triphenylacrylonitriles implicate... J Med Chem. 1992 Feb 7;35(3):573-83. DM4LIUC RU https://pubmed.ncbi.nlm.nih.gov/1738150 DM4LIUC DI DM4LIUC DM4LIUC DN 4-cycloheptyliden(4-hydroxyphenyl)methylphenol DM4LIUC MI TTBZ7OD DM4LIUC MN Protein kinase C epsilon (PRKCE) DM4LIUC MT DTT DM4LIUC MA Inhibitor DM4LIUC RN Multivariate analysis by the minimum spanning tree method of the structural determinants of diphenylethylenes and triphenylacrylonitriles implicate... J Med Chem. 1992 Feb 7;35(3):573-83. DM4LIUC RU https://pubmed.ncbi.nlm.nih.gov/1738150 DM4LIUC DI DM4LIUC DM4LIUC DN 4-cycloheptyliden(4-hydroxyphenyl)methylphenol DM4LIUC MI TTRFOXJ DM4LIUC MN Protein kinase C gamma (PRKCG) DM4LIUC MT DTT DM4LIUC MA Inhibitor DM4LIUC RN Multivariate analysis by the minimum spanning tree method of the structural determinants of diphenylethylenes and triphenylacrylonitriles implicate... J Med Chem. 1992 Feb 7;35(3):573-83. DM4LIUC RU https://pubmed.ncbi.nlm.nih.gov/1738150 DM4LIUC DI DM4LIUC DM4LIUC DN 4-cycloheptyliden(4-hydroxyphenyl)methylphenol DM4LIUC MI TT8QL1J DM4LIUC MN Protein kinase C theta (PRKCQ) DM4LIUC MT DTT DM4LIUC MA Inhibitor DM4LIUC RN Multivariate analysis by the minimum spanning tree method of the structural determinants of diphenylethylenes and triphenylacrylonitriles implicate... J Med Chem. 1992 Feb 7;35(3):573-83. DM4LIUC RU https://pubmed.ncbi.nlm.nih.gov/1738150 DM4LIUC DI DM4LIUC DM4LIUC DN 4-cycloheptyliden(4-hydroxyphenyl)methylphenol DM4LIUC MI TTUWGRA DM4LIUC MN Protein kinase C zeta (PRKCZ) DM4LIUC MT DTT DM4LIUC MA Inhibitor DM4LIUC RN Multivariate analysis by the minimum spanning tree method of the structural determinants of diphenylethylenes and triphenylacrylonitriles implicate... J Med Chem. 1992 Feb 7;35(3):573-83. DM4LIUC RU https://pubmed.ncbi.nlm.nih.gov/1738150 DMTFL5J DI DMTFL5J DMTFL5J DN 4-Cyclohexyl-4-hydroxy-but-2-enoic acid DMTFL5J MI TT6TKEN DMTFL5J MN Gamma-hydroxybutyrate receptor (SLC52A2) DMTFL5J MT DTT DMTFL5J MA Inhibitor DMTFL5J RN Analogues of gamma-hydroxybutyric acid. Synthesis and binding studies. J Med Chem. 1988 May;31(5):893-7. DMTFL5J RU https://pubmed.ncbi.nlm.nih.gov/3361576 DM10U6S DI DM10U6S DM10U6S DN 4-cyclohexyl-6-propylpyrimidine-2-carbonitrile DM10U6S MI TTDZN01 DM10U6S MN Cathepsin K (CTSK) DM10U6S MT DTT DM10U6S MA Inhibitor DM10U6S RN Design and optimization of a series of novel 2-cyano-pyrimidines as cathepsin K inhibitors. Bioorg Med Chem Lett. 2010 Mar 1;20(5):1524-7. DM10U6S RU https://pubmed.ncbi.nlm.nih.gov/20149657 DMGVIXW DI DMGVIXW DMGVIXW DN 4-cyclohexylamino-pyrimidine-2-carbonitrile DMGVIXW MI TTDZN01 DMGVIXW MN Cathepsin K (CTSK) DMGVIXW MT DTT DMGVIXW MA Inhibitor DMGVIXW RN 2-Cyano-pyrimidines: a new chemotype for inhibitors of the cysteine protease cathepsin K. J Med Chem. 2007 Feb 22;50(4):591-4. DMGVIXW RU https://pubmed.ncbi.nlm.nih.gov/17256925 DM8BLK2 DI DM8BLK2 DM8BLK2 DN 4-cyclohexyliden(4-hydroxyphenyl)methylphenol DM8BLK2 MI TTFJ8Q1 DM8BLK2 MN Protein kinase C alpha (PRKCA) DM8BLK2 MT DTT DM8BLK2 MA Inhibitor DM8BLK2 RN Multivariate analysis by the minimum spanning tree method of the structural determinants of diphenylethylenes and triphenylacrylonitriles implicate... J Med Chem. 1992 Feb 7;35(3):573-83. DM8BLK2 RU https://pubmed.ncbi.nlm.nih.gov/1738150 DM8BLK2 DI DM8BLK2 DM8BLK2 DN 4-cyclohexyliden(4-hydroxyphenyl)methylphenol DM8BLK2 MI TTYPXQF DM8BLK2 MN Protein kinase C beta (PRKCB) DM8BLK2 MT DTT DM8BLK2 MA Inhibitor DM8BLK2 RN Multivariate analysis by the minimum spanning tree method of the structural determinants of diphenylethylenes and triphenylacrylonitriles implicate... J Med Chem. 1992 Feb 7;35(3):573-83. DM8BLK2 RU https://pubmed.ncbi.nlm.nih.gov/1738150 DM8BLK2 DI DM8BLK2 DM8BLK2 DN 4-cyclohexyliden(4-hydroxyphenyl)methylphenol DM8BLK2 MI TT9WJ8U DM8BLK2 MN Protein kinase C delta (PRKCD) DM8BLK2 MT DTT DM8BLK2 MA Inhibitor DM8BLK2 RN Multivariate analysis by the minimum spanning tree method of the structural determinants of diphenylethylenes and triphenylacrylonitriles implicate... J Med Chem. 1992 Feb 7;35(3):573-83. DM8BLK2 RU https://pubmed.ncbi.nlm.nih.gov/1738150 DM8BLK2 DI DM8BLK2 DM8BLK2 DN 4-cyclohexyliden(4-hydroxyphenyl)methylphenol DM8BLK2 MI TTBZ7OD DM8BLK2 MN Protein kinase C epsilon (PRKCE) DM8BLK2 MT DTT DM8BLK2 MA Inhibitor DM8BLK2 RN Multivariate analysis by the minimum spanning tree method of the structural determinants of diphenylethylenes and triphenylacrylonitriles implicate... J Med Chem. 1992 Feb 7;35(3):573-83. DM8BLK2 RU https://pubmed.ncbi.nlm.nih.gov/1738150 DM8BLK2 DI DM8BLK2 DM8BLK2 DN 4-cyclohexyliden(4-hydroxyphenyl)methylphenol DM8BLK2 MI TTRFOXJ DM8BLK2 MN Protein kinase C gamma (PRKCG) DM8BLK2 MT DTT DM8BLK2 MA Inhibitor DM8BLK2 RN Multivariate analysis by the minimum spanning tree method of the structural determinants of diphenylethylenes and triphenylacrylonitriles implicate... J Med Chem. 1992 Feb 7;35(3):573-83. DM8BLK2 RU https://pubmed.ncbi.nlm.nih.gov/1738150 DM8BLK2 DI DM8BLK2 DM8BLK2 DN 4-cyclohexyliden(4-hydroxyphenyl)methylphenol DM8BLK2 MI TT8QL1J DM8BLK2 MN Protein kinase C theta (PRKCQ) DM8BLK2 MT DTT DM8BLK2 MA Inhibitor DM8BLK2 RN Multivariate analysis by the minimum spanning tree method of the structural determinants of diphenylethylenes and triphenylacrylonitriles implicate... J Med Chem. 1992 Feb 7;35(3):573-83. DM8BLK2 RU https://pubmed.ncbi.nlm.nih.gov/1738150 DM8BLK2 DI DM8BLK2 DM8BLK2 DN 4-cyclohexyliden(4-hydroxyphenyl)methylphenol DM8BLK2 MI TTUWGRA DM8BLK2 MN Protein kinase C zeta (PRKCZ) DM8BLK2 MT DTT DM8BLK2 MA Inhibitor DM8BLK2 RN Multivariate analysis by the minimum spanning tree method of the structural determinants of diphenylethylenes and triphenylacrylonitriles implicate... J Med Chem. 1992 Feb 7;35(3):573-83. DM8BLK2 RU https://pubmed.ncbi.nlm.nih.gov/1738150 DMS42TN DI DMS42TN DMS42TN DN 4-cyclooctyl-6-propylpyrimidine-2-carbonitrile DMS42TN MI TTDZN01 DMS42TN MN Cathepsin K (CTSK) DMS42TN MT DTT DMS42TN MA Inhibitor DMS42TN RN Design and optimization of a series of novel 2-cyano-pyrimidines as cathepsin K inhibitors. Bioorg Med Chem Lett. 2010 Mar 1;20(5):1524-7. DMS42TN RU https://pubmed.ncbi.nlm.nih.gov/20149657 DMS42TN DI DMS42TN DMS42TN DN 4-cyclooctyl-6-propylpyrimidine-2-carbonitrile DMS42TN MI TTUMQVO DMS42TN MN Cathepsin S (CTSS) DMS42TN MT DTT DMS42TN MA Inhibitor DMS42TN RN Design and optimization of a series of novel 2-cyano-pyrimidines as cathepsin K inhibitors. Bioorg Med Chem Lett. 2010 Mar 1;20(5):1524-7. DMS42TN RU https://pubmed.ncbi.nlm.nih.gov/20149657 DM7LN53 DI DM7LN53 DM7LN53 DN 4-cyclopentyliden(4-hydroxyphenyl)methylphenol DM7LN53 MI TTFJ8Q1 DM7LN53 MN Protein kinase C alpha (PRKCA) DM7LN53 MT DTT DM7LN53 MA Inhibitor DM7LN53 RN Multivariate analysis by the minimum spanning tree method of the structural determinants of diphenylethylenes and triphenylacrylonitriles implicate... J Med Chem. 1992 Feb 7;35(3):573-83. DM7LN53 RU https://pubmed.ncbi.nlm.nih.gov/1738150 DM7LN53 DI DM7LN53 DM7LN53 DN 4-cyclopentyliden(4-hydroxyphenyl)methylphenol DM7LN53 MI TTYPXQF DM7LN53 MN Protein kinase C beta (PRKCB) DM7LN53 MT DTT DM7LN53 MA Inhibitor DM7LN53 RN Multivariate analysis by the minimum spanning tree method of the structural determinants of diphenylethylenes and triphenylacrylonitriles implicate... J Med Chem. 1992 Feb 7;35(3):573-83. DM7LN53 RU https://pubmed.ncbi.nlm.nih.gov/1738150 DM7LN53 DI DM7LN53 DM7LN53 DN 4-cyclopentyliden(4-hydroxyphenyl)methylphenol DM7LN53 MI TTRFOXJ DM7LN53 MN Protein kinase C gamma (PRKCG) DM7LN53 MT DTT DM7LN53 MA Inhibitor DM7LN53 RN Multivariate analysis by the minimum spanning tree method of the structural determinants of diphenylethylenes and triphenylacrylonitriles implicate... J Med Chem. 1992 Feb 7;35(3):573-83. DM7LN53 RU https://pubmed.ncbi.nlm.nih.gov/1738150 DMZIUQ2 DI DMZIUQ2 DMZIUQ2 DN 4-DAMP DMZIUQ2 MI TTQ13Z5 DMZIUQ2 MN Muscarinic acetylcholine receptor M3 (CHRM3) DMZIUQ2 MT DTT DMZIUQ2 MA Antagonist DMZIUQ2 RN An increase in intracelluar free calcium ions modulated by cholinergic receptors in rat facial nucleus. Chin Med J (Engl). 2009 May 5;122(9):1049-55. DMZIUQ2 RU https://pubmed.ncbi.nlm.nih.gov/19493439 DMGQTF9 DI DMGQTF9 DMGQTF9 DN 4-decyl-N-(pyridin-3-yl)benzamide DMGQTF9 MI TTMI6F5 DMGQTF9 MN Transient receptor potential cation channel V1 (TRPV1) DMGQTF9 MT DTT DMGQTF9 MA Inhibitor DMGQTF9 RN N-pyridin-3-yl- and N-quinolin-3-yl-benzamides: modulators of human vanilloid receptor 1 (TRPV1). Bioorg Med Chem Lett. 2008 Apr 15;18(8):2730-4. DMGQTF9 RU https://pubmed.ncbi.nlm.nih.gov/18359227 DM93DQG DI DM93DQG DM93DQG DN 4-dehydroxyriccardin C DM93DQG MI TTECBXN DM93DQG MN Oxysterols receptor LXR-alpha (NR1H3) DM93DQG MT DTT DM93DQG MA Inhibitor DM93DQG RN Co-existence of alpha-glucosidase-inhibitory and liver X receptor-regulatory activities and their separation by structural development. Bioorg Med Chem. 2008 Apr 15;16(8):4272-85. DM93DQG RU https://pubmed.ncbi.nlm.nih.gov/18343126 DM93DQG DI DM93DQG DM93DQG DN 4-dehydroxyriccardin C DM93DQG MI TTXA6PH DM93DQG MN Oxysterols receptor LXR-beta (NR1H2) DM93DQG MT DTT DM93DQG MA Inhibitor DM93DQG RN Co-existence of alpha-glucosidase-inhibitory and liver X receptor-regulatory activities and their separation by structural development. Bioorg Med Chem. 2008 Apr 15;16(8):4272-85. DM93DQG RU https://pubmed.ncbi.nlm.nih.gov/18343126 DMQWHLM DI DMQWHLM DMQWHLM DN 4'-Demethyl-4beta-amino-4-desoxypodophyllotoxin DMQWHLM MI TT0IHXV DMQWHLM MN DNA topoisomerase II (TOP2) DMQWHLM MT DTT DMQWHLM MA Inhibitor DMQWHLM RN Antitumor agents, 107. New cytotoxic 4-alkylamino analogues of 4'-demethyl-epipodophyllotoxin as inhibitors of human DNA topoisomerase II. J Nat Prod. 1989 May-Jun;52(3):606-13. DMQWHLM RU https://pubmed.ncbi.nlm.nih.gov/2550587 DMIWX3B DI DMIWX3B DMIWX3B DN 4'-Demethyl-epipodophyllotoxin DMIWX3B MI TT0IHXV DMIWX3B MN DNA topoisomerase II (TOP2) DMIWX3B MT DTT DMIWX3B MA Inhibitor DMIWX3B RN Antitumor agents, 107. New cytotoxic 4-alkylamino analogues of 4'-demethyl-epipodophyllotoxin as inhibitors of human DNA topoisomerase II. J Nat Prod. 1989 May-Jun;52(3):606-13. DMIWX3B RU https://pubmed.ncbi.nlm.nih.gov/2550587 DMEC1PS DI DMEC1PS DMEC1PS DN 4-Dimethylamino-2,6-diisopropyl-phenol DMEC1PS MI TTNJYV2 DMEC1PS MN Gamma-aminobutyric acid receptor (GAR) DMEC1PS MT DTT DMEC1PS MA Inhibitor DMEC1PS RN Propofol analogues. Synthesis, relationships between structure and affinity at GABAA receptor in rat brain, and differential electrophysiological p... J Med Chem. 1998 May 21;41(11):1846-54. DMEC1PS RU https://pubmed.ncbi.nlm.nih.gov/9599235 DM0M8G5 DI DM0M8G5 DM0M8G5 DN 4-Dimethylamino-N-(6-mercapto-hexyl)-benzamide DM0M8G5 MI TTBH0VX DM0M8G5 MN Histone deacetylase (HDAC) DM0M8G5 MT DTT DM0M8G5 MA Inhibitor DM0M8G5 RN Novel inhibitors of human histone deacetylases: design, synthesis, enzyme inhibition, and cancer cell growth inhibition of SAHA-based non-hydroxama... J Med Chem. 2005 Feb 24;48(4):1019-32. DM0M8G5 RU https://pubmed.ncbi.nlm.nih.gov/15715470 DM0M8G5 DI DM0M8G5 DM0M8G5 DN 4-Dimethylamino-N-(6-mercapto-hexyl)-benzamide DM0M8G5 MI TT6R7JZ DM0M8G5 MN Histone deacetylase 1 (HDAC1) DM0M8G5 MT DTT DM0M8G5 MA Inhibitor DM0M8G5 RN Novel inhibitors of human histone deacetylases: design, synthesis, enzyme inhibition, and cancer cell growth inhibition of SAHA-based non-hydroxama... J Med Chem. 2005 Feb 24;48(4):1019-32. DM0M8G5 RU https://pubmed.ncbi.nlm.nih.gov/15715470 DM0M8G5 DI DM0M8G5 DM0M8G5 DN 4-Dimethylamino-N-(6-mercapto-hexyl)-benzamide DM0M8G5 MI TTYHPU6 DM0M8G5 MN Histone deacetylase 10 (HDAC10) DM0M8G5 MT DTT DM0M8G5 MA Inhibitor DM0M8G5 RN Novel inhibitors of human histone deacetylases: design, synthesis, enzyme inhibition, and cancer cell growth inhibition of SAHA-based non-hydroxama... J Med Chem. 2005 Feb 24;48(4):1019-32. DM0M8G5 RU https://pubmed.ncbi.nlm.nih.gov/15715470 DM0M8G5 DI DM0M8G5 DM0M8G5 DN 4-Dimethylamino-N-(6-mercapto-hexyl)-benzamide DM0M8G5 MI TTSHTOI DM0M8G5 MN Histone deacetylase 2 (HDAC2) DM0M8G5 MT DTT DM0M8G5 MA Inhibitor DM0M8G5 RN Novel inhibitors of human histone deacetylases: design, synthesis, enzyme inhibition, and cancer cell growth inhibition of SAHA-based non-hydroxama... J Med Chem. 2005 Feb 24;48(4):1019-32. DM0M8G5 RU https://pubmed.ncbi.nlm.nih.gov/15715470 DM0M8G5 DI DM0M8G5 DM0M8G5 DN 4-Dimethylamino-N-(6-mercapto-hexyl)-benzamide DM0M8G5 MI TTTQGH8 DM0M8G5 MN Histone deacetylase 4 (HDAC4) DM0M8G5 MT DTT DM0M8G5 MA Inhibitor DM0M8G5 RN Novel inhibitors of human histone deacetylases: design, synthesis, enzyme inhibition, and cancer cell growth inhibition of SAHA-based non-hydroxama... J Med Chem. 2005 Feb 24;48(4):1019-32. DM0M8G5 RU https://pubmed.ncbi.nlm.nih.gov/15715470 DM0M8G5 DI DM0M8G5 DM0M8G5 DN 4-Dimethylamino-N-(6-mercapto-hexyl)-benzamide DM0M8G5 MI TT5ZKDI DM0M8G5 MN Histone deacetylase 6 (HDAC6) DM0M8G5 MT DTT DM0M8G5 MA Inhibitor DM0M8G5 RN Novel inhibitors of human histone deacetylases: design, synthesis, enzyme inhibition, and cancer cell growth inhibition of SAHA-based non-hydroxama... J Med Chem. 2005 Feb 24;48(4):1019-32. DM0M8G5 RU https://pubmed.ncbi.nlm.nih.gov/15715470 DM0M8G5 DI DM0M8G5 DM0M8G5 DN 4-Dimethylamino-N-(6-mercapto-hexyl)-benzamide DM0M8G5 MI TTT6LFV DM0M8G5 MN Histone deacetylase 8 (HDAC8) DM0M8G5 MT DTT DM0M8G5 MA Inhibitor DM0M8G5 RN Novel inhibitors of human histone deacetylases: design, synthesis, enzyme inhibition, and cancer cell growth inhibition of SAHA-based non-hydroxama... J Med Chem. 2005 Feb 24;48(4):1019-32. DM0M8G5 RU https://pubmed.ncbi.nlm.nih.gov/15715470 DMKEHLD DI DMKEHLD DMKEHLD DN 4-Dipropylamino-cyclohex-1-enecarbonitrile DMKEHLD MI TT4C8EA DMKEHLD MN Dopamine D3 receptor (D3R) DMKEHLD MT DTT DMKEHLD MA Inhibitor DMKEHLD RN Conjugated enynes as nonaromatic catechol bioisosteres: synthesis, binding experiments, and computational studies of novel dopamine receptor agonis... J Med Chem. 2000 Feb 24;43(4):756-62. DMKEHLD RU https://pubmed.ncbi.nlm.nih.gov/10691700 DMD6ROZ DI DMD6ROZ DMD6ROZ DN 4E2Rcat DMD6ROZ MI TTXQ1JS DMD6ROZ MN HUAMN eIF4E-eIF4G interaction (eIF4E-eIF4G) DMD6ROZ MT DTT DMD6ROZ MA Inhibitor DMD6ROZ RN Blocking eIF4E-eIF4G interaction as a strategy to impair coronavirus replication. J Virol. 2011 Jul;85(13):6381-9. DMD6ROZ RU https://pubmed.ncbi.nlm.nih.gov/21507972 DM8WAOR DI DM8WAOR DM8WAOR DN 4-Ethoxy-3-pyridinesulfonamide DM8WAOR MI TTHQPL7 DM8WAOR MN Carbonic anhydrase I (CA-I) DM8WAOR MT DTT DM8WAOR MA Inhibitor DM8WAOR RN Carbonic anhydrase inhibitors: synthesis and inhibition of the human cytosolic isozymes I and II and transmembrane isozymes IX, XII (cancer-associa... Eur J Med Chem. 2010 Jun;45(6):2396-404. DM8WAOR RU https://pubmed.ncbi.nlm.nih.gov/20202722 DM8WAOR DI DM8WAOR DM8WAOR DN 4-Ethoxy-3-pyridinesulfonamide DM8WAOR MI TTANPDJ DM8WAOR MN Carbonic anhydrase II (CA-II) DM8WAOR MT DTT DM8WAOR MA Inhibitor DM8WAOR RN Carbonic anhydrase inhibitors: synthesis and inhibition of the human cytosolic isozymes I and II and transmembrane isozymes IX, XII (cancer-associa... Eur J Med Chem. 2010 Jun;45(6):2396-404. DM8WAOR RU https://pubmed.ncbi.nlm.nih.gov/20202722 DM8WAOR DI DM8WAOR DM8WAOR DN 4-Ethoxy-3-pyridinesulfonamide DM8WAOR MI TT2LVK8 DM8WAOR MN Carbonic anhydrase IX (CA-IX) DM8WAOR MT DTT DM8WAOR MA Inhibitor DM8WAOR RN Carbonic anhydrase inhibitors: synthesis and inhibition of the human cytosolic isozymes I and II and transmembrane isozymes IX, XII (cancer-associa... Eur J Med Chem. 2010 Jun;45(6):2396-404. DM8WAOR RU https://pubmed.ncbi.nlm.nih.gov/20202722 DM8WAOR DI DM8WAOR DM8WAOR DN 4-Ethoxy-3-pyridinesulfonamide DM8WAOR MI TTSYM0R DM8WAOR MN Carbonic anhydrase XII (CA-XII) DM8WAOR MT DTT DM8WAOR MA Inhibitor DM8WAOR RN Carbonic anhydrase inhibitors: synthesis and inhibition of the human cytosolic isozymes I and II and transmembrane isozymes IX, XII (cancer-associa... Eur J Med Chem. 2010 Jun;45(6):2396-404. DM8WAOR RU https://pubmed.ncbi.nlm.nih.gov/20202722 DM8WAOR DI DM8WAOR DM8WAOR DN 4-Ethoxy-3-pyridinesulfonamide DM8WAOR MI TTEYTKG DM8WAOR MN Carbonic anhydrase XIV (CA-XIV) DM8WAOR MT DTT DM8WAOR MA Inhibitor DM8WAOR RN Carbonic anhydrase inhibitors: synthesis and inhibition of the human cytosolic isozymes I and II and transmembrane isozymes IX, XII (cancer-associa... Eur J Med Chem. 2010 Jun;45(6):2396-404. DM8WAOR RU https://pubmed.ncbi.nlm.nih.gov/20202722 DM8642Z DI DM8642Z DM8642Z DN 4-Ethoxy-7-((E)-styryl)-furo[3,2-g]chromen-5-one DM8642Z MI TTK25J1 DM8642Z MN Adenosine A1 receptor (ADORA1) DM8642Z MT DTT DM8642Z MA Antagonist DM8642Z RN Synthesis and biological activities of flavonoid derivatives as A3 adenosine receptor antagonists. J Med Chem. 1996 Jun 7;39(12):2293-301. DM8642Z RU https://pubmed.ncbi.nlm.nih.gov/8691424 DM8642Z DI DM8642Z DM8642Z DN 4-Ethoxy-7-((E)-styryl)-furo[3,2-g]chromen-5-one DM8642Z MI TTNE7KG DM8642Z MN Adenosine A2b receptor (ADORA2B) DM8642Z MT DTT DM8642Z MA Antagonist DM8642Z RN Synthesis and biological activities of flavonoid derivatives as A3 adenosine receptor antagonists. J Med Chem. 1996 Jun 7;39(12):2293-301. DM8642Z RU https://pubmed.ncbi.nlm.nih.gov/8691424 DM8642Z DI DM8642Z DM8642Z DN 4-Ethoxy-7-((E)-styryl)-furo[3,2-g]chromen-5-one DM8642Z MI TTJFY5U DM8642Z MN Adenosine A3 receptor (ADORA3) DM8642Z MT DTT DM8642Z MA Inhibitor DM8642Z RN Synthesis and biological activities of flavonoid derivatives as A3 adenosine receptor antagonists. J Med Chem. 1996 Jun 7;39(12):2293-301. DM8642Z RU https://pubmed.ncbi.nlm.nih.gov/8691424 DMUN7KC DI DMUN7KC DMUN7KC DN 4-ethoxynaphthalene-1,2-dione DMUN7KC MI TTG8HIM DMUN7KC MN Dual specificity protein phosphatase 1 (DUSP1) DMUN7KC MT DTT DMUN7KC MA Inhibitor DMUN7KC RN Bioactivities of simplified adociaquinone B and naphthoquinone derivatives against Cdc25B, MKP-1, and MKP-3 phosphatases. Bioorg Med Chem. 2009 Mar 15;17(6):2276-81. DMUN7KC RU https://pubmed.ncbi.nlm.nih.gov/19028102 DMUN7KC DI DMUN7KC DMUN7KC DN 4-ethoxynaphthalene-1,2-dione DMUN7KC MI TTR0SWN DMUN7KC MN M-phase inducer phosphatase 2 (MPIP2) DMUN7KC MT DTT DMUN7KC MA Inhibitor DMUN7KC RN Bioactivities of simplified adociaquinone B and naphthoquinone derivatives against Cdc25B, MKP-1, and MKP-3 phosphatases. Bioorg Med Chem. 2009 Mar 15;17(6):2276-81. DMUN7KC RU https://pubmed.ncbi.nlm.nih.gov/19028102 DMTIY89 DI DMTIY89 DMTIY89 DN 4-Ethyl-2-(4-hydroxy-phenyl)-quinolin-6-ol DMTIY89 MI TTZAYWL DMTIY89 MN Estrogen receptor (ESR) DMTIY89 MT DTT DMTIY89 MA Inhibitor DMTIY89 RN ERbeta ligands. Part 4: Synthesis and structure-activity relationships of a series of 2-phenylquinoline derivatives. Bioorg Med Chem Lett. 2005 Oct 15;15(20):4520-5. DMTIY89 RU https://pubmed.ncbi.nlm.nih.gov/16098741 DMTIY89 DI DMTIY89 DMTIY89 DN 4-Ethyl-2-(4-hydroxy-phenyl)-quinolin-6-ol DMTIY89 MI TTOM3J0 DMTIY89 MN Estrogen receptor beta (ESR2) DMTIY89 MT DTT DMTIY89 MA Inhibitor DMTIY89 RN ERbeta ligands. Part 4: Synthesis and structure-activity relationships of a series of 2-phenylquinoline derivatives. Bioorg Med Chem Lett. 2005 Oct 15;15(20):4520-5. DMTIY89 RU https://pubmed.ncbi.nlm.nih.gov/16098741 DMTIY89 DI DMTIY89 DMTIY89 DN 4-Ethyl-2-(4-hydroxy-phenyl)-quinolin-6-ol DMTIY89 MI TTPNQAC DMTIY89 MN Estrogen-related receptor-alpha (ESRRA) DMTIY89 MT DTT DMTIY89 MA Inhibitor DMTIY89 RN ERbeta ligands. Part 6: 6H-Chromeno[4,3-b]quinolines as a new series of estrogen receptor beta-selective ligands. Bioorg Med Chem Lett. 2007 Jul 15;17(14):4053-6. DMTIY89 RU https://pubmed.ncbi.nlm.nih.gov/17482813 DMHDN25 DI DMHDN25 DMHDN25 DN 4-ethyl-3,4-dihydroquinazolin-2-amine DMHDN25 MI TTRUFDT DMHDN25 MN 5-HT 5A receptor (HTR5A) DMHDN25 MT DTT DMHDN25 MA Inhibitor DMHDN25 RN Cyclic guanidines as dual 5-HT5A/5-HT7 receptor ligands: structure-activity relationship elucidation. Bioorg Med Chem Lett. 2008 Jan 1;18(1):256-61. DMHDN25 RU https://pubmed.ncbi.nlm.nih.gov/17998160 DM5G3NU DI DM5G3NU DM5G3NU DN 4-Ethyl-3-methyl-pyrrolidin-(2Z)-ylideneamine DM5G3NU MI TTZUFI5 DM5G3NU MN Nitric-oxide synthase brain (NOS1) DM5G3NU MT DTT DM5G3NU MA Inhibitor DM5G3NU RN Evaluation of pyrrolidin-2-imines and 1,3-thiazolidin-2-imines as inhibitors of nitric oxide synthase. Bioorg Med Chem Lett. 2004 Sep 6;14(17):4539-44. DM5G3NU RU https://pubmed.ncbi.nlm.nih.gov/15357988 DM5G3NU DI DM5G3NU DM5G3NU DN 4-Ethyl-3-methyl-pyrrolidin-(2Z)-ylideneamine DM5G3NU MI TTF10I9 DM5G3NU MN Nitric-oxide synthase inducible (NOS2) DM5G3NU MT DTT DM5G3NU MA Inhibitor DM5G3NU RN Evaluation of pyrrolidin-2-imines and 1,3-thiazolidin-2-imines as inhibitors of nitric oxide synthase. Bioorg Med Chem Lett. 2004 Sep 6;14(17):4539-44. DM5G3NU RU https://pubmed.ncbi.nlm.nih.gov/15357988 DMTM1VD DI DMTM1VD DMTM1VD DN 4-Ethyl-5,6-dihydro-1H-pyridin-(2Z)-ylideneamine DMTM1VD MI TTCM4B3 DMTM1VD MN Nitric-oxide synthase endothelial (NOS3) DMTM1VD MT DTT DMTM1VD MA Inhibitor DMTM1VD RN Design and synthesis of orally bioavailable inhibitors of inducible nitric oxide synthase. Part 1: synthesis and biological evaluation of dihydropy... Bioorg Med Chem Lett. 2002 Sep 2;12(17):2291-4. DMTM1VD RU https://pubmed.ncbi.nlm.nih.gov/12161118 DMOAQ1E DI DMOAQ1E DMOAQ1E DN 4-Ethyl-5-methyl-pyrrolidin-(2Z)-ylideneamine DMOAQ1E MI TTZUFI5 DMOAQ1E MN Nitric-oxide synthase brain (NOS1) DMOAQ1E MT DTT DMOAQ1E MA Inhibitor DMOAQ1E RN Evaluation of pyrrolidin-2-imines and 1,3-thiazolidin-2-imines as inhibitors of nitric oxide synthase. Bioorg Med Chem Lett. 2004 Sep 6;14(17):4539-44. DMOAQ1E RU https://pubmed.ncbi.nlm.nih.gov/15357988 DMOAQ1E DI DMOAQ1E DMOAQ1E DN 4-Ethyl-5-methyl-pyrrolidin-(2Z)-ylideneamine DMOAQ1E MI TTCM4B3 DMOAQ1E MN Nitric-oxide synthase endothelial (NOS3) DMOAQ1E MT DTT DMOAQ1E MA Inhibitor DMOAQ1E RN Evaluation of pyrrolidin-2-imines and 1,3-thiazolidin-2-imines as inhibitors of nitric oxide synthase. Bioorg Med Chem Lett. 2004 Sep 6;14(17):4539-44. DMOAQ1E RU https://pubmed.ncbi.nlm.nih.gov/15357988 DMOAQ1E DI DMOAQ1E DMOAQ1E DN 4-Ethyl-5-methyl-pyrrolidin-(2Z)-ylideneamine DMOAQ1E MI TTF10I9 DMOAQ1E MN Nitric-oxide synthase inducible (NOS2) DMOAQ1E MT DTT DMOAQ1E MA Inhibitor DMOAQ1E RN Evaluation of pyrrolidin-2-imines and 1,3-thiazolidin-2-imines as inhibitors of nitric oxide synthase. Bioorg Med Chem Lett. 2004 Sep 6;14(17):4539-44. DMOAQ1E RU https://pubmed.ncbi.nlm.nih.gov/15357988 DMYO2GP DI DMYO2GP DMYO2GP DN 4-Ethyl-5-piperidin-4-yl-isoxazol-3-ol DMYO2GP MI TTNJYV2 DMYO2GP MN Gamma-aminobutyric acid receptor (GAR) DMYO2GP MT DTT DMYO2GP MA Inhibitor DMYO2GP RN A novel class of potent 3-isoxazolol GABA(A) antagonists: design, synthesis, and pharmacology. J Med Chem. 2000 Dec 28;43(26):4930-3. DMYO2GP RU https://pubmed.ncbi.nlm.nih.gov/11150163 DMG0Y3W DI DMG0Y3W DMG0Y3W DN 4-Ethyl-oxazolidin-(2Z)-ylideneamine DMG0Y3W MI TTZUFI5 DMG0Y3W MN Nitric-oxide synthase brain (NOS1) DMG0Y3W MT DTT DMG0Y3W MA Inhibitor DMG0Y3W RN 4,5-Disubstituted-1,3-oxazolidin-2-imine derivatives: a new class of orally bioavailable nitric oxide synthase inhibitor. Bioorg Med Chem Lett. 2004 Jan 19;14(2):313-6. DMG0Y3W RU https://pubmed.ncbi.nlm.nih.gov/14698148 DMG0Y3W DI DMG0Y3W DMG0Y3W DN 4-Ethyl-oxazolidin-(2Z)-ylideneamine DMG0Y3W MI TTF10I9 DMG0Y3W MN Nitric-oxide synthase inducible (NOS2) DMG0Y3W MT DTT DMG0Y3W MA Inhibitor DMG0Y3W RN 4,5-Disubstituted-1,3-oxazolidin-2-imine derivatives: a new class of orally bioavailable nitric oxide synthase inhibitor. Bioorg Med Chem Lett. 2004 Jan 19;14(2):313-6. DMG0Y3W RU https://pubmed.ncbi.nlm.nih.gov/14698148 DMYIWAH DI DMYIWAH DMYIWAH DN 4-Ethyl-pyrrolidin-(2Z)-ylideneamine DMYIWAH MI TTZUFI5 DMYIWAH MN Nitric-oxide synthase brain (NOS1) DMYIWAH MT DTT DMYIWAH MA Inhibitor DMYIWAH RN Evaluation of pyrrolidin-2-imines and 1,3-thiazolidin-2-imines as inhibitors of nitric oxide synthase. Bioorg Med Chem Lett. 2004 Sep 6;14(17):4539-44. DMYIWAH RU https://pubmed.ncbi.nlm.nih.gov/15357988 DMYIWAH DI DMYIWAH DMYIWAH DN 4-Ethyl-pyrrolidin-(2Z)-ylideneamine DMYIWAH MI TTCM4B3 DMYIWAH MN Nitric-oxide synthase endothelial (NOS3) DMYIWAH MT DTT DMYIWAH MA Inhibitor DMYIWAH RN Evaluation of pyrrolidin-2-imines and 1,3-thiazolidin-2-imines as inhibitors of nitric oxide synthase. Bioorg Med Chem Lett. 2004 Sep 6;14(17):4539-44. DMYIWAH RU https://pubmed.ncbi.nlm.nih.gov/15357988 DMYIWAH DI DMYIWAH DMYIWAH DN 4-Ethyl-pyrrolidin-(2Z)-ylideneamine DMYIWAH MI TTF10I9 DMYIWAH MN Nitric-oxide synthase inducible (NOS2) DMYIWAH MT DTT DMYIWAH MA Inhibitor DMYIWAH RN Evaluation of pyrrolidin-2-imines and 1,3-thiazolidin-2-imines as inhibitors of nitric oxide synthase. Bioorg Med Chem Lett. 2004 Sep 6;14(17):4539-44. DMYIWAH RU https://pubmed.ncbi.nlm.nih.gov/15357988 DMIF1D6 DI DMIF1D6 DMIF1D6 DN 4-ethynyl benzene sulfonamide DMIF1D6 MI TTHQPL7 DMIF1D6 MN Carbonic anhydrase I (CA-I) DMIF1D6 MT DTT DMIF1D6 MA Inhibitor DMIF1D6 RN Inhibition of carbonic anhydrases with glycosyltriazole benzene sulfonamides. J Med Chem. 2008 Mar 27;51(6):1945-53. DMIF1D6 RU https://pubmed.ncbi.nlm.nih.gov/18307288 DMIF1D6 DI DMIF1D6 DMIF1D6 DN 4-ethynyl benzene sulfonamide DMIF1D6 MI TTANPDJ DMIF1D6 MN Carbonic anhydrase II (CA-II) DMIF1D6 MT DTT DMIF1D6 MA Inhibitor DMIF1D6 RN Inhibition of carbonic anhydrases with glycosyltriazole benzene sulfonamides. J Med Chem. 2008 Mar 27;51(6):1945-53. DMIF1D6 RU https://pubmed.ncbi.nlm.nih.gov/18307288 DMIF1D6 DI DMIF1D6 DMIF1D6 DN 4-ethynyl benzene sulfonamide DMIF1D6 MI TT2LVK8 DMIF1D6 MN Carbonic anhydrase IX (CA-IX) DMIF1D6 MT DTT DMIF1D6 MA Inhibitor DMIF1D6 RN Inhibition of carbonic anhydrases with glycosyltriazole benzene sulfonamides. J Med Chem. 2008 Mar 27;51(6):1945-53. DMIF1D6 RU https://pubmed.ncbi.nlm.nih.gov/18307288 DMXLZAT DI DMXLZAT DMXLZAT DN 4-Ethynyl-2-(4-hydroxy-phenyl)-quinolin-6-ol DMXLZAT MI TTZAYWL DMXLZAT MN Estrogen receptor (ESR) DMXLZAT MT DTT DMXLZAT MA Inhibitor DMXLZAT RN ERbeta ligands. Part 4: Synthesis and structure-activity relationships of a series of 2-phenylquinoline derivatives. Bioorg Med Chem Lett. 2005 Oct 15;15(20):4520-5. DMXLZAT RU https://pubmed.ncbi.nlm.nih.gov/16098741 DMXLZAT DI DMXLZAT DMXLZAT DN 4-Ethynyl-2-(4-hydroxy-phenyl)-quinolin-6-ol DMXLZAT MI TTOM3J0 DMXLZAT MN Estrogen receptor beta (ESR2) DMXLZAT MT DTT DMXLZAT MA Inhibitor DMXLZAT RN ERbeta ligands. Part 4: Synthesis and structure-activity relationships of a series of 2-phenylquinoline derivatives. Bioorg Med Chem Lett. 2005 Oct 15;15(20):4520-5. DMXLZAT RU https://pubmed.ncbi.nlm.nih.gov/16098741 DMXLZAT DI DMXLZAT DMXLZAT DN 4-Ethynyl-2-(4-hydroxy-phenyl)-quinolin-6-ol DMXLZAT MI TTPNQAC DMXLZAT MN Estrogen-related receptor-alpha (ESRRA) DMXLZAT MT DTT DMXLZAT MA Inhibitor DMXLZAT RN ERbeta ligands. Part 6: 6H-Chromeno[4,3-b]quinolines as a new series of estrogen receptor beta-selective ligands. Bioorg Med Chem Lett. 2007 Jul 15;17(14):4053-6. DMXLZAT RU https://pubmed.ncbi.nlm.nih.gov/17482813 DMNDS19 DI DMNDS19 DMNDS19 DN 4-Flourobenzenesulfonamide DMNDS19 MI TTANPDJ DMNDS19 MN Carbonic anhydrase II (CA-II) DMNDS19 MT DTT DMNDS19 MA Inhibitor DMNDS19 RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMNDS19 RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMW9I1X DI DMW9I1X DMW9I1X DN 4-Fluoren-9-ylidenemethyl-pyridine DMW9I1X MI TTSZLWK DMW9I1X MN Aromatase (CYP19A1) DMW9I1X MT DTT DMW9I1X MA Inhibitor DMW9I1X RN Synthesis and evaluation of (pyridylmethylene)tetrahydronaphthalenes/-indanes and structurally modified derivatives: potent and selective inhibitor... J Med Chem. 2005 Mar 10;48(5):1563-75. DMW9I1X RU https://pubmed.ncbi.nlm.nih.gov/15743198 DM0INZX DI DM0INZX DM0INZX DN 4-Fluoro-1,1':4',1''-terphenyl-3,3''-diol DM0INZX MI TTIWB6L DM0INZX MN Estradiol 17 beta-dehydrogenase 1 (17-beta-HSD1) DM0INZX MT DTT DM0INZX MA Inhibitor DM0INZX RN New insights into the SAR and binding modes of bis(hydroxyphenyl)thiophenes and -benzenes: influence of additional substituents on 17beta-hydroxyst... J Med Chem. 2009 Nov 12;52(21):6724-43. DM0INZX RU https://pubmed.ncbi.nlm.nih.gov/19831396 DMQ1D9A DI DMQ1D9A DMQ1D9A DN 4'-FLUORO-1,1'-BIPHENYL-4-CARBOXYLIC ACID DMQ1D9A MI TTU1E82 DMQ1D9A MN Apoptosis regulator Bcl-xL (BCL-xL) DMQ1D9A MT DTT DMQ1D9A MA Inhibitor DMQ1D9A RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DMQ1D9A RU https://pubmed.ncbi.nlm.nih.gov/10592235 DM2N4BJ DI DM2N4BJ DM2N4BJ DN 4-fluorobenzaldehyde O-benzoyloxime DM2N4BJ MI TTDNFMT DM2N4BJ MN Platelet-activating factor acetylhydrolase (PLA2G7) DM2N4BJ MT DTT DM2N4BJ MA Inhibitor DM2N4BJ RN Potent inhibitors of lipoprotein-associated phospholipase A(2): benzaldehyde O-heterocycle-4-carbonyloxime. Bioorg Med Chem Lett. 2006 Nov 1;16(21):5576-9. DM2N4BJ RU https://pubmed.ncbi.nlm.nih.gov/16919943 DMS6RHD DI DMS6RHD DMS6RHD DN 4-Fluorobenzenemethanethiol DMS6RHD MI TTZJYKH DMS6RHD MN Indoleamine 2,3-dioxygenase 1 (IDO1) DMS6RHD MT DTT DMS6RHD MA Inhibitor DMS6RHD RN S-benzylisothiourea derivatives as small-molecule inhibitors of indoleamine-2,3-dioxygenase. Bioorg Med Chem Lett. 2010 Sep 1;20(17):5126-9. DMS6RHD RU https://pubmed.ncbi.nlm.nih.gov/20688518 DMWD42N DI DMWD42N DMWD42N DN 4-fluorobenzoyl-Phe-Gly-Leu-Arg-Trp-NH2 DMWD42N MI TT3KBZY DMWD42N MN G-protein coupled receptor 54 (KISS1R) DMWD42N MT DTT DMWD42N MA Inhibitor DMWD42N RN Development of novel G-protein-coupled receptor 54 agonists with resistance to degradation by matrix metalloproteinase. J Med Chem. 2008 Dec 11;51(23):7645-9. DMWD42N RU https://pubmed.ncbi.nlm.nih.gov/19007202 DMV6M5U DI DMV6M5U DMV6M5U DN 4-fluoro-N-(4-(methylsulfonyl)phenyl)aniline DMV6M5U MI TTVKILB DMV6M5U MN Prostaglandin G/H synthase 2 (COX-2) DMV6M5U MT DTT DMV6M5U MA Inhibitor DMV6M5U RN Synthesis, anti-inflammatory activity, and in vitro antitumor effect of a novel class of cyclooxygenase inhibitors: 4-(aryloyl)phenyl methyl sulfones. J Med Chem. 2010 Sep 23;53(18):6560-71. DMV6M5U RU https://pubmed.ncbi.nlm.nih.gov/20804197 DMGBKN7 DI DMGBKN7 DMGBKN7 DN 4-fluoro-N-(4-sulfamoylbenzyl)benzenesulfonamide DMGBKN7 MI TTHQPL7 DMGBKN7 MN Carbonic anhydrase I (CA-I) DMGBKN7 MT DTT DMGBKN7 MA Inhibitor DMGBKN7 RN Ligand-based and structure-based virtual screening to identify carbonic anhydrase IX inhibitors. Bioorg Med Chem. 2009 Jan 15;17(2):553-7. DMGBKN7 RU https://pubmed.ncbi.nlm.nih.gov/19097911 DMGBKN7 DI DMGBKN7 DMGBKN7 DN 4-fluoro-N-(4-sulfamoylbenzyl)benzenesulfonamide DMGBKN7 MI TTANPDJ DMGBKN7 MN Carbonic anhydrase II (CA-II) DMGBKN7 MT DTT DMGBKN7 MA Inhibitor DMGBKN7 RN Ligand-based and structure-based virtual screening to identify carbonic anhydrase IX inhibitors. Bioorg Med Chem. 2009 Jan 15;17(2):553-7. DMGBKN7 RU https://pubmed.ncbi.nlm.nih.gov/19097911 DMGBKN7 DI DMGBKN7 DMGBKN7 DN 4-fluoro-N-(4-sulfamoylbenzyl)benzenesulfonamide DMGBKN7 MI TT2LVK8 DMGBKN7 MN Carbonic anhydrase IX (CA-IX) DMGBKN7 MT DTT DMGBKN7 MA Inhibitor DMGBKN7 RN Ligand-based and structure-based virtual screening to identify carbonic anhydrase IX inhibitors. Bioorg Med Chem. 2009 Jan 15;17(2):553-7. DMGBKN7 RU https://pubmed.ncbi.nlm.nih.gov/19097911 DMZV3MD DI DMZV3MD DMZV3MD DN 4-fluorophenyl 1-(4-butoxyphenyl)propylcarbamate DMZV3MD MI TTDP1UC DMZV3MD MN Fatty acid amide hydrolase (FAAH) DMZV3MD MT DTT DMZV3MD MA Inhibitor DMZV3MD RN Oxime carbamate--discovery of a series of novel FAAH inhibitors. Bioorg Med Chem Lett. 2010 Feb 1;20(3):1272-7. DMZV3MD RU https://pubmed.ncbi.nlm.nih.gov/20036536 DMCRJ54 DI DMCRJ54 DMCRJ54 DN 4-fluorophenyl 4-butoxybenzylcarbamate DMCRJ54 MI TTDP1UC DMCRJ54 MN Fatty acid amide hydrolase (FAAH) DMCRJ54 MT DTT DMCRJ54 MA Inhibitor DMCRJ54 RN Oxime carbamate--discovery of a series of novel FAAH inhibitors. Bioorg Med Chem Lett. 2010 Feb 1;20(3):1272-7. DMCRJ54 RU https://pubmed.ncbi.nlm.nih.gov/20036536 DMI03KV DI DMI03KV DMI03KV DN 4-fluorophenyl-2,2-diphenylacetamide DMI03KV MI TTMNI76 DMI03KV MN Calcium-activated potassium channel (KCN) DMI03KV MT DTT DMI03KV MA Inhibitor DMI03KV RN Novel inhibitors of the Gardos channel for the treatment of sickle cell disease. J Med Chem. 2008 Feb 28;51(4):976-82. DMI03KV RU https://pubmed.ncbi.nlm.nih.gov/18232633 DMD5LXQ DI DMD5LXQ DMD5LXQ DN 4-fluorophenylboronic acid DMD5LXQ MI TTDP1UC DMD5LXQ MN Fatty acid amide hydrolase (FAAH) DMD5LXQ MT DTT DMD5LXQ MA Inhibitor DMD5LXQ RN Discovery of boronic acids as novel and potent inhibitors of fatty acid amide hydrolase. J Med Chem. 2008 Nov 27;51(22):7057-60. DMD5LXQ RU https://pubmed.ncbi.nlm.nih.gov/18983140 DMRC49E DI DMRC49E DMRC49E DN 4-fluoroselegiline DMRC49E MI TTGP7BY DMRC49E MN Monoamine oxidase type B (MAO-B) DMRC49E MT DTT DMRC49E MA Modulator DMRC49E RN Multiple, small dose administration of (-)deprenyl enhances catecholaminergic activity and diminishes serotoninergic activity in the brain and these effects are unrelated to MAO-B inhibition. Arch Int Pharmacodyn Ther. 1994 Jul-Aug;328(1):1-15. DMRC49E RU https://pubmed.ncbi.nlm.nih.gov/7893186 DM1VNEF DI DM1VNEF DM1VNEF DN 4-formylphenyl-O-beta-Dglucopyranoside DM1VNEF MI TT1RS9F DM1VNEF MN Acetylcholinesterase (AChE) DM1VNEF MT DTT DM1VNEF MA Inhibitor DM1VNEF RN Synthesis and biological evaluation of helicid analogues as novel acetylcholinesterase inhibitors. Eur J Med Chem. 2008 Jan;43(1):166-73. DM1VNEF RU https://pubmed.ncbi.nlm.nih.gov/17574306 DM7DW0G DI DM7DW0G DM7DW0G DN 4-formylphenyl-O-beta-D-ribopyranoside DM7DW0G MI TT1RS9F DM7DW0G MN Acetylcholinesterase (AChE) DM7DW0G MT DTT DM7DW0G MA Inhibitor DM7DW0G RN Synthesis and biological evaluation of helicid analogues as novel acetylcholinesterase inhibitors. Eur J Med Chem. 2008 Jan;43(1):166-73. DM7DW0G RU https://pubmed.ncbi.nlm.nih.gov/17574306 DMKT915 DI DMKT915 DMKT915 DN 4-Furan-2-yl-6-nitro-2-piperazin-1-yl-quinoline DMKT915 MI TT3ROYC DMKT915 MN Serotonin transporter (SERT) DMKT915 MT DTT DMKT915 MA Inhibitor DMKT915 RN Syntheses and binding affinities of 6-nitroquipazine analogues for serotonin transporter. Part 2: 4-substituted 6-nitroquipazines. Bioorg Med Chem Lett. 2002 Mar 11;12(5):811-5. DMKT915 RU https://pubmed.ncbi.nlm.nih.gov/11859009 DMRF9NH DI DMRF9NH DMRF9NH DN 4'-GALACTOSYLLACTOSE DMRF9NH MI DELUCK5 DMRF9NH MN Oligosaccharyltransferase (pglB) DMRF9NH MT DME DMRF9NH MA Metabolism DMRF9NH RN Characterization of N-linked protein glycosylation in Helicobacter pullorum. J Bacteriol. 2010 Oct;192(19):5228-36. DMRF9NH RU https://pubmed.ncbi.nlm.nih.gov/20581208 DMRF9NH DI DMRF9NH DMRF9NH DN 4'-GALACTOSYLLACTOSE DMRF9NH MI DETD1FG DMRF9NH MN Oligosaccharyltransferase (pglB) DMRF9NH MT DME DMRF9NH MA Metabolism DMRF9NH RN Characterization of N-linked protein glycosylation in Helicobacter pullorum. J Bacteriol. 2010 Oct;192(19):5228-36. DMRF9NH RU https://pubmed.ncbi.nlm.nih.gov/20581208 DMRF9NH DI DMRF9NH DMRF9NH DN 4'-GALACTOSYLLACTOSE DMRF9NH MI DEZKVM5 DMRF9NH MN Oligosaccharyltransferase (pglB) DMRF9NH MT DME DMRF9NH MA Metabolism DMRF9NH RN Characterization of N-linked protein glycosylation in Helicobacter pullorum. J Bacteriol. 2010 Oct;192(19):5228-36. DMRF9NH RU https://pubmed.ncbi.nlm.nih.gov/20581208 DM5MHO6 DI DM5MHO6 DM5MHO6 DN 4-Hept-3-ynyl-1H-imidazole DM5MHO6 MI TT9JNIC DM5MHO6 MN Histamine H3 receptor (H3R) DM5MHO6 MT DTT DM5MHO6 MA Inhibitor DM5MHO6 RN New acetylene based histamine H3 receptor antagonists derived from the marine natural product verongamine. Bioorg Med Chem Lett. 1998 May 19;8(10):1133-8. DM5MHO6 RU https://pubmed.ncbi.nlm.nih.gov/9871722 DMA3MX5 DI DMA3MX5 DMA3MX5 DN 4-heptyl-N-(pyridin-3-yl)benzamide DMA3MX5 MI TTMI6F5 DMA3MX5 MN Transient receptor potential cation channel V1 (TRPV1) DMA3MX5 MT DTT DMA3MX5 MA Inhibitor DMA3MX5 RN N-pyridin-3-yl- and N-quinolin-3-yl-benzamides: modulators of human vanilloid receptor 1 (TRPV1). Bioorg Med Chem Lett. 2008 Apr 15;18(8):2730-4. DMA3MX5 RU https://pubmed.ncbi.nlm.nih.gov/18359227 DMAHLF6 DI DMAHLF6 DMAHLF6 DN 4-heptyl-N-(quinolin-3-yl)benzamide DMAHLF6 MI TTMI6F5 DMAHLF6 MN Transient receptor potential cation channel V1 (TRPV1) DMAHLF6 MT DTT DMAHLF6 MA Inhibitor DMAHLF6 RN N-pyridin-3-yl- and N-quinolin-3-yl-benzamides: modulators of human vanilloid receptor 1 (TRPV1). Bioorg Med Chem Lett. 2008 Apr 15;18(8):2730-4. DMAHLF6 RU https://pubmed.ncbi.nlm.nih.gov/18359227 DMYNTJ0 DI DMYNTJ0 DMYNTJ0 DN 4-Hex-3-ynyl-1H-imidazole DMYNTJ0 MI TT9JNIC DMYNTJ0 MN Histamine H3 receptor (H3R) DMYNTJ0 MT DTT DMYNTJ0 MA Inhibitor DMYNTJ0 RN New acetylene based histamine H3 receptor antagonists derived from the marine natural product verongamine. Bioorg Med Chem Lett. 1998 May 19;8(10):1133-8. DMYNTJ0 RU https://pubmed.ncbi.nlm.nih.gov/9871722 DM36JUD DI DM36JUD DM36JUD DN 4-hexyl resorcinol DM36JUD MI TTULVH8 DM36JUD MN Tyrosinase (TYR) DM36JUD MT DTT DM36JUD MA Inhibitor DM36JUD RN PEG-immobilization of cardol and soluble polymer-supported synthesis of some cardol-coumarin derivatives: preliminary evaluation of their inhibitor... Bioorg Med Chem Lett. 2009 Jan 1;19(1):36-9. DM36JUD RU https://pubmed.ncbi.nlm.nih.gov/19054671 DM5E03C DI DM5E03C DM5E03C DN 4-hexyl-N-(quinolin-3-yl)benzamide DM5E03C MI TTMI6F5 DM5E03C MN Transient receptor potential cation channel V1 (TRPV1) DM5E03C MT DTT DM5E03C MA Inhibitor DM5E03C RN N-pyridin-3-yl- and N-quinolin-3-yl-benzamides: modulators of human vanilloid receptor 1 (TRPV1). Bioorg Med Chem Lett. 2008 Apr 15;18(8):2730-4. DM5E03C RU https://pubmed.ncbi.nlm.nih.gov/18359227 DMONZ0Y DI DMONZ0Y DMONZ0Y DN 4-hexylphenyl propiolate DMONZ0Y MI TTTSEPU DMONZ0Y MN Thyroid hormone receptor alpha (THRA) DMONZ0Y MT DTT DMONZ0Y MA Inhibitor DMONZ0Y RN Inhibitors of the interaction of a thyroid hormone receptor and coactivators: preliminary structure-activity relationships. J Med Chem. 2007 Nov 1;50(22):5269-80. DMONZ0Y RU https://pubmed.ncbi.nlm.nih.gov/17918822 DMONZ0Y DI DMONZ0Y DMONZ0Y DN 4-hexylphenyl propiolate DMONZ0Y MI TTGER3L DMONZ0Y MN Thyroid hormone receptor beta (THRB) DMONZ0Y MT DTT DMONZ0Y MA Inhibitor DMONZ0Y RN Inhibitors of the interaction of a thyroid hormone receptor and coactivators: preliminary structure-activity relationships. J Med Chem. 2007 Nov 1;50(22):5269-80. DMONZ0Y RU https://pubmed.ncbi.nlm.nih.gov/17918822 DMSZMQU DI DMSZMQU DMSZMQU DN 4-Hydrazino-3-pyridinesulfonamide DMSZMQU MI TTHQPL7 DMSZMQU MN Carbonic anhydrase I (CA-I) DMSZMQU MT DTT DMSZMQU MA Inhibitor DMSZMQU RN Carbonic anhydrase inhibitors: synthesis and inhibition of the human cytosolic isozymes I and II and transmembrane isozymes IX, XII (cancer-associa... Eur J Med Chem. 2010 Jun;45(6):2396-404. DMSZMQU RU https://pubmed.ncbi.nlm.nih.gov/20202722 DMSZMQU DI DMSZMQU DMSZMQU DN 4-Hydrazino-3-pyridinesulfonamide DMSZMQU MI TTANPDJ DMSZMQU MN Carbonic anhydrase II (CA-II) DMSZMQU MT DTT DMSZMQU MA Inhibitor DMSZMQU RN Carbonic anhydrase inhibitors: synthesis and inhibition of the human cytosolic isozymes I and II and transmembrane isozymes IX, XII (cancer-associa... Eur J Med Chem. 2010 Jun;45(6):2396-404. DMSZMQU RU https://pubmed.ncbi.nlm.nih.gov/20202722 DMSZMQU DI DMSZMQU DMSZMQU DN 4-Hydrazino-3-pyridinesulfonamide DMSZMQU MI TT2LVK8 DMSZMQU MN Carbonic anhydrase IX (CA-IX) DMSZMQU MT DTT DMSZMQU MA Inhibitor DMSZMQU RN Carbonic anhydrase inhibitors: synthesis and inhibition of the human cytosolic isozymes I and II and transmembrane isozymes IX, XII (cancer-associa... Eur J Med Chem. 2010 Jun;45(6):2396-404. DMSZMQU RU https://pubmed.ncbi.nlm.nih.gov/20202722 DMSZMQU DI DMSZMQU DMSZMQU DN 4-Hydrazino-3-pyridinesulfonamide DMSZMQU MI TTSYM0R DMSZMQU MN Carbonic anhydrase XII (CA-XII) DMSZMQU MT DTT DMSZMQU MA Inhibitor DMSZMQU RN Carbonic anhydrase inhibitors: synthesis and inhibition of the human cytosolic isozymes I and II and transmembrane isozymes IX, XII (cancer-associa... Eur J Med Chem. 2010 Jun;45(6):2396-404. DMSZMQU RU https://pubmed.ncbi.nlm.nih.gov/20202722 DMSZMQU DI DMSZMQU DMSZMQU DN 4-Hydrazino-3-pyridinesulfonamide DMSZMQU MI TTEYTKG DMSZMQU MN Carbonic anhydrase XIV (CA-XIV) DMSZMQU MT DTT DMSZMQU MA Inhibitor DMSZMQU RN Carbonic anhydrase inhibitors: synthesis and inhibition of the human cytosolic isozymes I and II and transmembrane isozymes IX, XII (cancer-associa... Eur J Med Chem. 2010 Jun;45(6):2396-404. DMSZMQU RU https://pubmed.ncbi.nlm.nih.gov/20202722 DM49B18 DI DM49B18 DM49B18 DN 4-Hydrazino-benzenesulfonamide DM49B18 MI TTUNARX DM49B18 MN Carbonic anhydrase (CA) DM49B18 MT DTT DM49B18 MA Inhibitor DM49B18 RN Cloning, expression, post-translational modifications and inhibition studies on the latest mammalian carbonic anhydrase isoform, CA XV. J Med Chem. 2009 Feb 12;52(3):646-54. DM49B18 RU https://pubmed.ncbi.nlm.nih.gov/19193158 DM49B18 DI DM49B18 DM49B18 DN 4-Hydrazino-benzenesulfonamide DM49B18 MI TTHQPL7 DM49B18 MN Carbonic anhydrase I (CA-I) DM49B18 MT DTT DM49B18 MA Inhibitor DM49B18 RN Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/membrane-associated carbonic anhydrase isozymes I, II, and IX with sulfonamide... J Med Chem. 2005 Mar 24;48(6):2121-5. DM49B18 RU https://pubmed.ncbi.nlm.nih.gov/15771455 DM49B18 DI DM49B18 DM49B18 DN 4-Hydrazino-benzenesulfonamide DM49B18 MI TTANPDJ DM49B18 MN Carbonic anhydrase II (CA-II) DM49B18 MT DTT DM49B18 MA Inhibitor DM49B18 RN Cloning, expression, post-translational modifications and inhibition studies on the latest mammalian carbonic anhydrase isoform, CA XV. J Med Chem. 2009 Feb 12;52(3):646-54. DM49B18 RU https://pubmed.ncbi.nlm.nih.gov/19193158 DM49B18 DI DM49B18 DM49B18 DN 4-Hydrazino-benzenesulfonamide DM49B18 MI TTZHA0O DM49B18 MN Carbonic anhydrase IV (CA-IV) DM49B18 MT DTT DM49B18 MA Inhibitor DM49B18 RN Carbonic anhydrase inhibitors. Inhibition of the membrane-bound human and bovine isozymes IV with sulfonamides. Bioorg Med Chem Lett. 2005 Feb 15;15(4):1149-54. DM49B18 RU https://pubmed.ncbi.nlm.nih.gov/15686931 DM49B18 DI DM49B18 DM49B18 DN 4-Hydrazino-benzenesulfonamide DM49B18 MI TT2LVK8 DM49B18 MN Carbonic anhydrase IX (CA-IX) DM49B18 MT DTT DM49B18 MA Inhibitor DM49B18 RN Cloning, expression, post-translational modifications and inhibition studies on the latest mammalian carbonic anhydrase isoform, CA XV. J Med Chem. 2009 Feb 12;52(3):646-54. DM49B18 RU https://pubmed.ncbi.nlm.nih.gov/19193158 DM49B18 DI DM49B18 DM49B18 DN 4-Hydrazino-benzenesulfonamide DM49B18 MI TTCFSPE DM49B18 MN Carbonic anhydrase VI (CA-VI) DM49B18 MT DTT DM49B18 MA Inhibitor DM49B18 RN Cloning, expression, post-translational modifications and inhibition studies on the latest mammalian carbonic anhydrase isoform, CA XV. J Med Chem. 2009 Feb 12;52(3):646-54. DM49B18 RU https://pubmed.ncbi.nlm.nih.gov/19193158 DM49B18 DI DM49B18 DM49B18 DN 4-Hydrazino-benzenesulfonamide DM49B18 MI TTSYM0R DM49B18 MN Carbonic anhydrase XII (CA-XII) DM49B18 MT DTT DM49B18 MA Inhibitor DM49B18 RN Carbonic anhydrase inhibitors: inhibition of the transmembrane isozyme XIV with sulfonamides. Bioorg Med Chem Lett. 2005 Sep 1;15(17):3828-33. DM49B18 RU https://pubmed.ncbi.nlm.nih.gov/16039848 DM49B18 DI DM49B18 DM49B18 DN 4-Hydrazino-benzenesulfonamide DM49B18 MI TTEYTKG DM49B18 MN Carbonic anhydrase XIV (CA-XIV) DM49B18 MT DTT DM49B18 MA Inhibitor DM49B18 RN Carbonic anhydrase inhibitors: inhibition of the transmembrane isozyme XIV with sulfonamides. Bioorg Med Chem Lett. 2005 Sep 1;15(17):3828-33. DM49B18 RU https://pubmed.ncbi.nlm.nih.gov/16039848 DM8PBEJ DI DM8PBEJ DM8PBEJ DN 4-Hydrazinocarbonyl-benzenesulfonamide DM8PBEJ MI TTHQPL7 DM8PBEJ MN Carbonic anhydrase I (CA-I) DM8PBEJ MT DTT DM8PBEJ MA Inhibitor DM8PBEJ RN Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/membrane-associated carbonic anhydrase isozymes I, II, and IX with sulfonamide... J Med Chem. 2005 Mar 24;48(6):2121-5. DM8PBEJ RU https://pubmed.ncbi.nlm.nih.gov/15771455 DM8PBEJ DI DM8PBEJ DM8PBEJ DN 4-Hydrazinocarbonyl-benzenesulfonamide DM8PBEJ MI TTANPDJ DM8PBEJ MN Carbonic anhydrase II (CA-II) DM8PBEJ MT DTT DM8PBEJ MA Inhibitor DM8PBEJ RN Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/membrane-associated carbonic anhydrase isozymes I, II, and IX with sulfonamide... J Med Chem. 2005 Mar 24;48(6):2121-5. DM8PBEJ RU https://pubmed.ncbi.nlm.nih.gov/15771455 DM8PBEJ DI DM8PBEJ DM8PBEJ DN 4-Hydrazinocarbonyl-benzenesulfonamide DM8PBEJ MI TT2LVK8 DM8PBEJ MN Carbonic anhydrase IX (CA-IX) DM8PBEJ MT DTT DM8PBEJ MA Inhibitor DM8PBEJ RN Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/membrane-associated carbonic anhydrase isozymes I, II, and IX with sulfonamide... J Med Chem. 2005 Mar 24;48(6):2121-5. DM8PBEJ RU https://pubmed.ncbi.nlm.nih.gov/15771455 DM6WJ4K DI DM6WJ4K DM6WJ4K DN 4-Hydroxy-1,2,5-Oxadiazole-3-Carboxylic Acid DM6WJ4K MI TTAZHU0 DM6WJ4K MN L-lactate dehydrogenase (LDH) DM6WJ4K MT DTT DM6WJ4K MA Inhibitor DM6WJ4K RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DM6WJ4K RU https://pubmed.ncbi.nlm.nih.gov/17139284 DME29PX DI DME29PX DME29PX DN 4-Hydroxy-1,2,5-Thiadiazole-3-Carboxylic Acid DME29PX MI TTAZHU0 DME29PX MN L-lactate dehydrogenase (LDH) DME29PX MT DTT DME29PX MA Inhibitor DME29PX RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DME29PX RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMTZ9G3 DI DMTZ9G3 DMTZ9G3 DN 4-hydroxy-1-methyl-4-(4-methylphenyl)-3-piperidyl 4-methylphenyl ketone DMTZ9G3 MI TT8DBY3 DMTZ9G3 MN Angiotensin II receptor type-1 (AGTR1) DMTZ9G3 MT DTT DMTZ9G3 MA Antagonist DMTZ9G3 RN Discovery of a novel dopamine transporter inhibitor, 4-hydroxy-1-methyl-4-(4-methylphenyl)-3-piperidyl 4-methylphenyl ketone, as a potential cocaine antagonist through 3D-database pharmacophore searching. Molecular modeling, structure-activity relationships, and behavioral pharmacological studies. J Med Chem. 2000 Feb 10;43(3):351-60. DMTZ9G3 RU https://pubmed.ncbi.nlm.nih.gov/10669562 DM7BQ65 DI DM7BQ65 DM7BQ65 DN 4-Hydroxy-2-Butanone DM7BQ65 MI TTMW94E DM7BQ65 MN FK506-binding protein 1A (FKBP1A) DM7BQ65 MT DTT DM7BQ65 MA Inhibitor DM7BQ65 RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DM7BQ65 RU https://pubmed.ncbi.nlm.nih.gov/17139284 DM2LJFZ DI DM2LJFZ DM2LJFZ DN 4-hydroxy-2-nonenal DM2LJFZ MI TTRPDBG DM2LJFZ MN Inhibitor of nuclear factor kappa-B kinase (IKK) DM2LJFZ MT DTT DM2LJFZ MA Inhibitor DM2LJFZ RN IkappaB kinase, a molecular target for inhibition by 4-hydroxy-2-nonenal. J Biol Chem. 2001 May 25;276(21):18223-8. DM2LJFZ RU https://pubmed.ncbi.nlm.nih.gov/11359792 DM2LJFZ DI DM2LJFZ DM2LJFZ DN 4-hydroxy-2-nonenal DM2LJFZ MI DE8RYV5 DM2LJFZ MN NADPH:quinone reductase (CRYZ) DM2LJFZ MT DME DM2LJFZ MA Metabolism DM2LJFZ RN Kinetic and structural evidence of the alkenal/one reductase specificity of human crystallin. Cell Mol Life Sci. 2011 Mar;68(6):1065-77. DM2LJFZ RU https://www.ncbi.nlm.nih.gov/pubmed/?term=20835842 DMY3OHK DI DMY3OHK DMY3OHK DN 4-Hydroxy-3-(1-naphthylmethyl)-2H-chromen-2-one DMY3OHK MI TT8XK6L DMY3OHK MN Quinone reductase 1 (NQO1) DMY3OHK MT DTT DMY3OHK MA Inhibitor DMY3OHK RN Synthesis and biological evaluation of coumarin-based inhibitors of NAD(P)H: quinone oxidoreductase-1 (NQO1). J Med Chem. 2009 Nov 26;52(22):7142-56. DMY3OHK RU https://pubmed.ncbi.nlm.nih.gov/19877692 DMM3QPL DI DMM3QPL DMM3QPL DN 4-Hydroxy-3-(2-naphthylmethyl)-2H-chromen-2-one DMM3QPL MI TT8XK6L DMM3QPL MN Quinone reductase 1 (NQO1) DMM3QPL MT DTT DMM3QPL MA Inhibitor DMM3QPL RN Synthesis and biological evaluation of coumarin-based inhibitors of NAD(P)H: quinone oxidoreductase-1 (NQO1). J Med Chem. 2009 Nov 26;52(22):7142-56. DMM3QPL RU https://pubmed.ncbi.nlm.nih.gov/19877692 DM2PS89 DI DM2PS89 DM2PS89 DN 4-Hydroxy-3,5-diisopropyl-benzaldehyde DM2PS89 MI TTNJYV2 DM2PS89 MN Gamma-aminobutyric acid receptor (GAR) DM2PS89 MT DTT DM2PS89 MA Inhibitor DM2PS89 RN Propofol analogues. Synthesis, relationships between structure and affinity at GABAA receptor in rat brain, and differential electrophysiological p... J Med Chem. 1998 May 21;41(11):1846-54. DM2PS89 RU https://pubmed.ncbi.nlm.nih.gov/9599235 DMWDBHC DI DMWDBHC DMWDBHC DN 4-Hydroxy-3-methyl-but-2-enoic acid DMWDBHC MI TT6TKEN DMWDBHC MN Gamma-hydroxybutyrate receptor (SLC52A2) DMWDBHC MT DTT DMWDBHC MA Inhibitor DMWDBHC RN Analogues of gamma-hydroxybutyric acid. Synthesis and binding studies. J Med Chem. 1988 May;31(5):893-7. DMWDBHC RU https://pubmed.ncbi.nlm.nih.gov/3361576 DM6AHO4 DI DM6AHO4 DM6AHO4 DN 4-Hydroxy-3-methyl-butyric acid DM6AHO4 MI TT6TKEN DM6AHO4 MN Gamma-hydroxybutyrate receptor (SLC52A2) DM6AHO4 MT DTT DM6AHO4 MA Inhibitor DM6AHO4 RN Analogues of gamma-hydroxybutyric acid. Synthesis and binding studies. J Med Chem. 1988 May;31(5):893-7. DM6AHO4 RU https://pubmed.ncbi.nlm.nih.gov/3361576 DMR0S8X DI DMR0S8X DMR0S8X DN 4-hydroxy-3-nitrobenzaldehyde DMR0S8X MI TTT2LD9 DMR0S8X MN GABA transaminase (ABAT) DMR0S8X MT DTT DMR0S8X MA Inhibitor DMR0S8X RN Inhibition of GABA shunt enzymes' activity by 4-hydroxybenzaldehyde derivatives. Bioorg Med Chem Lett. 2006 Feb;16(3):592-5. DMR0S8X RU https://pubmed.ncbi.nlm.nih.gov/16290145 DMDEMV8 DI DMDEMV8 DMDEMV8 DN 4-Hydroxy-3-nonanoyl-6-octyl-pyran-2-one DMDEMV8 MI TTPLTSQ DMDEMV8 MN Neutrophil elastase (NE) DMDEMV8 MT DTT DMDEMV8 MA Inhibitor DMDEMV8 RN Inhibition of human sputum elastase by substituted 2-pyrones. J Med Chem. 1987 Jun;30(6):1017-23. DMDEMV8 RU https://pubmed.ncbi.nlm.nih.gov/3647139 DMIVQGW DI DMIVQGW DMIVQGW DN 4-Hydroxy-4-phenyl-but-2-enoic acid DMIVQGW MI TT6TKEN DMIVQGW MN Gamma-hydroxybutyrate receptor (SLC52A2) DMIVQGW MT DTT DMIVQGW MA Inhibitor DMIVQGW RN Analogues of gamma-hydroxybutyric acid. Synthesis and binding studies. J Med Chem. 1988 May;31(5):893-7. DMIVQGW RU https://pubmed.ncbi.nlm.nih.gov/3361576 DMDWGS9 DI DMDWGS9 DMDWGS9 DN 4-Hydroxy-4-phenyl-butyric acid DMDWGS9 MI TT6TKEN DMDWGS9 MN Gamma-hydroxybutyrate receptor (SLC52A2) DMDWGS9 MT DTT DMDWGS9 MA Inhibitor DMDWGS9 RN Analogues of gamma-hydroxybutyric acid. Synthesis and binding studies. J Med Chem. 1988 May;31(5):893-7. DMDWGS9 RU https://pubmed.ncbi.nlm.nih.gov/3361576 DMVFKSX DI DMVFKSX DMVFKSX DN 4-Hydroxy-5-methoxy-10H-anthracen-9-one DMVFKSX MI TT2J34L DMVFKSX MN Arachidonate 5-lipoxygenase (5-LOX) DMVFKSX MT DTT DMVFKSX MA Inhibitor DMVFKSX RN Simple analogues of anthralin: unusual specificity of structure and antiproliferative activity. J Med Chem. 1997 Nov 7;40(23):3773-80. DMVFKSX RU https://pubmed.ncbi.nlm.nih.gov/9371243 DMT3H2X DI DMT3H2X DMT3H2X DN 4-hydroxy-5-phenylthieno[2,3-b]pyridin-6(7H)-one DMT3H2X MI TTLD29N DMT3H2X MN Glutamate receptor ionotropic NMDA 1 (NMDAR1) DMT3H2X MT DTT DMT3H2X MA Inhibitor DMT3H2X RN Synthesis of thieno[2,3-b]pyridinones acting as cytoprotectants and as inhibitors of [3H]glycine binding to the N-methyl-D-aspartate (NMDA) receptor. J Med Chem. 2006 Feb 9;49(3):864-71. DMT3H2X RU https://pubmed.ncbi.nlm.nih.gov/16451052 DMT3H2X DI DMT3H2X DMT3H2X DN 4-hydroxy-5-phenylthieno[2,3-b]pyridin-6(7H)-one DMT3H2X MI TTKJEMQ DMT3H2X MN Glutamate receptor ionotropic NMDA 2A (NMDAR2A) DMT3H2X MT DTT DMT3H2X MA Inhibitor DMT3H2X RN Synthesis of thieno[2,3-b]pyridinones acting as cytoprotectants and as inhibitors of [3H]glycine binding to the N-methyl-D-aspartate (NMDA) receptor. J Med Chem. 2006 Feb 9;49(3):864-71. DMT3H2X RU https://pubmed.ncbi.nlm.nih.gov/16451052 DMT3H2X DI DMT3H2X DMT3H2X DN 4-hydroxy-5-phenylthieno[2,3-b]pyridin-6(7H)-one DMT3H2X MI TTN9D8E DMT3H2X MN Glutamate receptor ionotropic NMDA 2B (NMDAR2B) DMT3H2X MT DTT DMT3H2X MA Inhibitor DMT3H2X RN Synthesis of thieno[2,3-b]pyridinones acting as cytoprotectants and as inhibitors of [3H]glycine binding to the N-methyl-D-aspartate (NMDA) receptor. J Med Chem. 2006 Feb 9;49(3):864-71. DMT3H2X RU https://pubmed.ncbi.nlm.nih.gov/16451052 DM7PWOL DI DM7PWOL DM7PWOL DN 4'-hydroxy-6,3',5'-triprenylisoflavonone DM7PWOL MI TT9V5JH DM7PWOL MN Phospholipase A2 (PLA2G1B) DM7PWOL MT DTT DM7PWOL MA Inhibitor DM7PWOL RN Phospholipase A2 Inhibitors from an Erythrina Species from Samoa J. Nat. Prod. 60(6):537-539 (1997). DM7PWOL RU http://pubs.acs.org/doi/abs/10.1021/np960533e DMH78QU DI DMH78QU DMH78QU DN 4-hydroxy-6-nitro-3-phenylquinolin-2(1H)-one DMH78QU MI TT7AOUD DMH78QU MN Fatty acid synthase (FASN) DMH78QU MT DTT DMH78QU MA Inhibitor DMH78QU RN 3-Aryl-4-hydroxyquinolin-2(1H)-one derivatives as type I fatty acid synthase inhibitors. Bioorg Med Chem Lett. 2006 Sep 1;16(17):4620-3. DMH78QU RU https://pubmed.ncbi.nlm.nih.gov/16784844 DMD3OV8 DI DMD3OV8 DMD3OV8 DN 4-hydroxy-8-nitro-3-phenylquinolin-2(1H)-one DMD3OV8 MI TT7AOUD DMD3OV8 MN Fatty acid synthase (FASN) DMD3OV8 MT DTT DMD3OV8 MA Inhibitor DMD3OV8 RN 3-Aryl-4-hydroxyquinolin-2(1H)-one derivatives as type I fatty acid synthase inhibitors. Bioorg Med Chem Lett. 2006 Sep 1;16(17):4620-3. DMD3OV8 RU https://pubmed.ncbi.nlm.nih.gov/16784844 DMT8L5R DI DMT8L5R DMT8L5R DN 4-Hydroxy-Aconitate Ion DMT8L5R MI TTMTF2P DMT8L5R MN Citrate hydro-lyase (ACO2) DMT8L5R MT DTT DMT8L5R MA Inhibitor DMT8L5R RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMT8L5R RU https://pubmed.ncbi.nlm.nih.gov/17139284 DM7WPGN DI DM7WPGN DM7WPGN DN 4-HYDROXYBENZALDEHYDE O-(CYCLOHEXYLCARBONYL)OXIME DM7WPGN MI TT2AST1 DM7WPGN MN Macrophage migration inhibitory factor (MIF) DM7WPGN MT DTT DM7WPGN MA Inhibitor DM7WPGN RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DM7WPGN RU https://pubmed.ncbi.nlm.nih.gov/10592235 DMJVPF0 DI DMJVPF0 DMJVPF0 DN 4-hydroxybenzylamine DMJVPF0 MI TTT2LD9 DMJVPF0 MN GABA transaminase (ABAT) DMJVPF0 MT DTT DMJVPF0 MA Inhibitor DMJVPF0 RN Inhibition of GABA shunt enzymes' activity by 4-hydroxybenzaldehyde derivatives. Bioorg Med Chem Lett. 2006 Feb;16(3):592-5. DMJVPF0 RU https://pubmed.ncbi.nlm.nih.gov/16290145 DMCA2XQ DI DMCA2XQ DMCA2XQ DN 4-hydroxy-but-2-enoate DMCA2XQ MI TT6TKEN DMCA2XQ MN Gamma-hydroxybutyrate receptor (SLC52A2) DMCA2XQ MT DTT DMCA2XQ MA Inhibitor DMCA2XQ RN Analogues of gamma-hydroxybutyric acid. Synthesis and binding studies. J Med Chem. 1988 May;31(5):893-7. DMCA2XQ RU https://pubmed.ncbi.nlm.nih.gov/3361576 DM36PHM DI DM36PHM DM36PHM DN 4-hydroxylonchocarpin DM36PHM MI TTUMGNO DM36PHM MN Ornithine decarboxylase (ODC1) DM36PHM MT DTT DM36PHM MA Inhibitor DM36PHM RN New bioactive flavonoids and stilbenes in cub resin insecticide. J Nat Prod. 1999 Feb;62(2):205-10. DM36PHM RU https://pubmed.ncbi.nlm.nih.gov/10075742 DMULOHZ DI DMULOHZ DMULOHZ DN 4-Hydroxy-N-(5-hydroxycarbamoyl-pentyl)-benzamide DMULOHZ MI TTBH0VX DMULOHZ MN Histone deacetylase (HDAC) DMULOHZ MT DTT DMULOHZ MA Inhibitor DMULOHZ RN Inhibitors of human histone deacetylase: synthesis and enzyme and cellular activity of straight chain hydroxamates. J Med Chem. 2002 Feb 14;45(4):753-7. DMULOHZ RU https://pubmed.ncbi.nlm.nih.gov/11831887 DMULOHZ DI DMULOHZ DMULOHZ DN 4-Hydroxy-N-(5-hydroxycarbamoyl-pentyl)-benzamide DMULOHZ MI TT6R7JZ DMULOHZ MN Histone deacetylase 1 (HDAC1) DMULOHZ MT DTT DMULOHZ MA Inhibitor DMULOHZ RN Inhibitors of human histone deacetylase: synthesis and enzyme and cellular activity of straight chain hydroxamates. J Med Chem. 2002 Feb 14;45(4):753-7. DMULOHZ RU https://pubmed.ncbi.nlm.nih.gov/11831887 DMULOHZ DI DMULOHZ DMULOHZ DN 4-Hydroxy-N-(5-hydroxycarbamoyl-pentyl)-benzamide DMULOHZ MI TTYHPU6 DMULOHZ MN Histone deacetylase 10 (HDAC10) DMULOHZ MT DTT DMULOHZ MA Inhibitor DMULOHZ RN Inhibitors of human histone deacetylase: synthesis and enzyme and cellular activity of straight chain hydroxamates. J Med Chem. 2002 Feb 14;45(4):753-7. DMULOHZ RU https://pubmed.ncbi.nlm.nih.gov/11831887 DMULOHZ DI DMULOHZ DMULOHZ DN 4-Hydroxy-N-(5-hydroxycarbamoyl-pentyl)-benzamide DMULOHZ MI TTSHTOI DMULOHZ MN Histone deacetylase 2 (HDAC2) DMULOHZ MT DTT DMULOHZ MA Inhibitor DMULOHZ RN Inhibitors of human histone deacetylase: synthesis and enzyme and cellular activity of straight chain hydroxamates. J Med Chem. 2002 Feb 14;45(4):753-7. DMULOHZ RU https://pubmed.ncbi.nlm.nih.gov/11831887 DMULOHZ DI DMULOHZ DMULOHZ DN 4-Hydroxy-N-(5-hydroxycarbamoyl-pentyl)-benzamide DMULOHZ MI TTTQGH8 DMULOHZ MN Histone deacetylase 4 (HDAC4) DMULOHZ MT DTT DMULOHZ MA Inhibitor DMULOHZ RN Inhibitors of human histone deacetylase: synthesis and enzyme and cellular activity of straight chain hydroxamates. J Med Chem. 2002 Feb 14;45(4):753-7. DMULOHZ RU https://pubmed.ncbi.nlm.nih.gov/11831887 DMULOHZ DI DMULOHZ DMULOHZ DN 4-Hydroxy-N-(5-hydroxycarbamoyl-pentyl)-benzamide DMULOHZ MI TT5ZKDI DMULOHZ MN Histone deacetylase 6 (HDAC6) DMULOHZ MT DTT DMULOHZ MA Inhibitor DMULOHZ RN Inhibitors of human histone deacetylase: synthesis and enzyme and cellular activity of straight chain hydroxamates. J Med Chem. 2002 Feb 14;45(4):753-7. DMULOHZ RU https://pubmed.ncbi.nlm.nih.gov/11831887 DMULOHZ DI DMULOHZ DMULOHZ DN 4-Hydroxy-N-(5-hydroxycarbamoyl-pentyl)-benzamide DMULOHZ MI TTT6LFV DMULOHZ MN Histone deacetylase 8 (HDAC8) DMULOHZ MT DTT DMULOHZ MA Inhibitor DMULOHZ RN Inhibitors of human histone deacetylase: synthesis and enzyme and cellular activity of straight chain hydroxamates. J Med Chem. 2002 Feb 14;45(4):753-7. DMULOHZ RU https://pubmed.ncbi.nlm.nih.gov/11831887 DMXPQ5H DI DMXPQ5H DMXPQ5H DN 4-hydroxy-N,N-diphenylbenzenesulfonamide DMXPQ5H MI TTZAYWL DMXPQ5H MN Estrogen receptor (ESR) DMXPQ5H MT DTT DMXPQ5H MA Inhibitor DMXPQ5H RN Substituted 4-hydroxyphenyl sulfonamides as pathway-selective estrogen receptor ligands. Bioorg Med Chem Lett. 2006 Feb 15;16(4):854-8. DMXPQ5H RU https://pubmed.ncbi.nlm.nih.gov/16300947 DMVAP9U DI DMVAP9U DMVAP9U DN 4-hydroxy-N-isopropyl-N-phenylbenzenesulfonamide DMVAP9U MI TTZAYWL DMVAP9U MN Estrogen receptor (ESR) DMVAP9U MT DTT DMVAP9U MA Inhibitor DMVAP9U RN Substituted 4-hydroxyphenyl sulfonamides as pathway-selective estrogen receptor ligands. Bioorg Med Chem Lett. 2006 Feb 15;16(4):854-8. DMVAP9U RU https://pubmed.ncbi.nlm.nih.gov/16300947 DM8XOJC DI DM8XOJC DM8XOJC DN 4-hydroxy-N-neopentyl-N-phenylbenzenesulfonamide DM8XOJC MI TTZAYWL DM8XOJC MN Estrogen receptor (ESR) DM8XOJC MT DTT DM8XOJC MA Inhibitor DM8XOJC RN Substituted 4-hydroxyphenyl sulfonamides as pathway-selective estrogen receptor ligands. Bioorg Med Chem Lett. 2006 Feb 15;16(4):854-8. DM8XOJC RU https://pubmed.ncbi.nlm.nih.gov/16300947 DM5TU98 DI DM5TU98 DM5TU98 DN 4-hydroxy-N-phenyl-N-propylbenzenesulfonamide DM5TU98 MI TTZAYWL DM5TU98 MN Estrogen receptor (ESR) DM5TU98 MT DTT DM5TU98 MA Inhibitor DM5TU98 RN Substituted 4-hydroxyphenyl sulfonamides as pathway-selective estrogen receptor ligands. Bioorg Med Chem Lett. 2006 Feb 15;16(4):854-8. DM5TU98 RU https://pubmed.ncbi.nlm.nih.gov/16300947 DMNMJDL DI DMNMJDL DMNMJDL DN 4-HYDROXY-N-PROPARGYL-1(R)-AMINOINDAN DMNMJDL MI TTGP7BY DMNMJDL MN Monoamine oxidase type B (MAO-B) DMNMJDL MT DTT DMNMJDL MA Inhibitor DMNMJDL RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DMNMJDL RU https://pubmed.ncbi.nlm.nih.gov/10592235 DM5ZQK1 DI DM5ZQK1 DM5ZQK1 DN 4-Hydroxy-pent-2-enoic acid DM5ZQK1 MI TT6TKEN DM5ZQK1 MN Gamma-hydroxybutyrate receptor (SLC52A2) DM5ZQK1 MT DTT DM5ZQK1 MA Inhibitor DM5ZQK1 RN Analogues of gamma-hydroxybutyric acid. Synthesis and binding studies. J Med Chem. 1988 May;31(5):893-7. DM5ZQK1 RU https://pubmed.ncbi.nlm.nih.gov/3361576 DMDGKFV DI DMDGKFV DMDGKFV DN 4-Hydroxy-pentanoic acid DMDGKFV MI TT6TKEN DMDGKFV MN Gamma-hydroxybutyrate receptor (SLC52A2) DMDGKFV MT DTT DMDGKFV MA Inhibitor DMDGKFV RN Analogues of gamma-hydroxybutyric acid. Synthesis and binding studies. J Med Chem. 1988 May;31(5):893-7. DMDGKFV RU https://pubmed.ncbi.nlm.nih.gov/3361576 DMJ7G0E DI DMJ7G0E DMJ7G0E DN 4-hydroxyphenethyl 3,4,5-trihydroxybenzoate DMJ7G0E MI TTULVH8 DMJ7G0E MN Tyrosinase (TYR) DMJ7G0E MT DTT DMJ7G0E MA Inhibitor DMJ7G0E RN Synthetic tyrosyl gallate derivatives as potent melanin formation inhibitors. Bioorg Med Chem Lett. 2007 Oct 1;17(19):5462-4. DMJ7G0E RU https://pubmed.ncbi.nlm.nih.gov/17693086 DM0564K DI DM0564K DM0564K DN 4-hydroxyphenylpyruvic acid DM0564K MI TT6L509 DM0564K MN Coagulation factor IIa (F2) DM0564K MT DTT DM0564K MA Inhibitor DM0564K RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DM0564K RU https://pubmed.ncbi.nlm.nih.gov/10592235 DM0564K DI DM0564K DM0564K DN 4-hydroxyphenylpyruvic acid DM0564K MI TT2AST1 DM0564K MN Macrophage migration inhibitory factor (MIF) DM0564K MT DTT DM0564K MA Inhibitor DM0564K RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DM0564K RU https://pubmed.ncbi.nlm.nih.gov/10592235 DM9VQ0T DI DM9VQ0T DM9VQ0T DN 4-Hydroxy-piperidine-3-carboxylic acid DM9VQ0T MI TTPRKM0 DM9VQ0T MN GABA transporter GAT-1 (SLC6A1) DM9VQ0T MT DTT DM9VQ0T MA Inhibitor DM9VQ0T RN Hydroxy- and amino-substituted piperidinecarboxylic acids as gamma-aminobutyric acid agonists and uptake inhibitors. J Med Chem. 1982 Oct;25(10):1157-62. DM9VQ0T RU https://pubmed.ncbi.nlm.nih.gov/6292417 DM9VQ0T DI DM9VQ0T DM9VQ0T DN 4-Hydroxy-piperidine-3-carboxylic acid DM9VQ0T MI TT8RXO5 DM9VQ0T MN GABA transporter-3 (SLC6A11) DM9VQ0T MT DTT DM9VQ0T MA Inhibitor DM9VQ0T RN Hydroxy- and amino-substituted piperidinecarboxylic acids as gamma-aminobutyric acid agonists and uptake inhibitors. J Med Chem. 1982 Oct;25(10):1157-62. DM9VQ0T RU https://pubmed.ncbi.nlm.nih.gov/6292417 DMPIV6J DI DMPIV6J DMPIV6J DN 4-hydroxysaprothoquinone DMPIV6J MI TTGTQHC DMPIV6J MN DNA topoisomerase I (TOP1) DMPIV6J MT DTT DMPIV6J MA Inhibitor DMPIV6J RN Bioactive abietane and seco-abietane diterpenoids from Salvia prionitis. J Nat Prod. 2002 Jul;65(7):1016-20. DMPIV6J RU https://pubmed.ncbi.nlm.nih.gov/12141863 DMJKF17 DI DMJKF17 DMJKF17 DN 4-Imidazol-1-yl-2-phenyl-chroman-7-ol DMJKF17 MI TTSZLWK DMJKF17 MN Aromatase (CYP19A1) DMJKF17 MT DTT DMJKF17 MA Inhibitor DMJKF17 RN Synthesis and evaluation of 4-triazolylflavans as new aromatase inhibitors. Bioorg Med Chem Lett. 2004 Oct 18;14(20):5215-8. DMJKF17 RU https://pubmed.ncbi.nlm.nih.gov/15380230 DM28DEU DI DM28DEU DM28DEU DN 4-Imidazol-1-ylmethyl-1-nitrothioxanthen-9-one DM28DEU MI TTSZLWK DM28DEU MN Aromatase (CYP19A1) DM28DEU MT DTT DM28DEU MA Inhibitor DM28DEU RN Novel highly potent and selective nonsteroidal aromatase inhibitors: synthesis, biological evaluation and structure-activity relationships investigation. J Med Chem. 2010 Jul 22;53(14):5347-51. DM28DEU RU https://pubmed.ncbi.nlm.nih.gov/20568782 DMZLVIF DI DMZLVIF DMZLVIF DN 4-Imidazol-1-ylmethyl-1-nitro-xanthen-9-one DMZLVIF MI TTSZLWK DMZLVIF MN Aromatase (CYP19A1) DMZLVIF MT DTT DMZLVIF MA Inhibitor DMZLVIF RN A new class of nonsteroidal aromatase inhibitors: design and synthesis of chromone and xanthone derivatives and inhibition of the P450 enzymes aromatase and 17 alpha-hydroxylase/C17,20-lyase. J Med Chem. 2001 Mar 1;44(5):672-80. DMZLVIF RU https://pubmed.ncbi.nlm.nih.gov/11262078 DM6FMO1 DI DM6FMO1 DM6FMO1 DN 4-Imidazol-1-ylmethyl-2-nitroxanthen-9-one DM6FMO1 MI TTSZLWK DM6FMO1 MN Aromatase (CYP19A1) DM6FMO1 MT DTT DM6FMO1 MA Inhibitor DM6FMO1 RN Novel highly potent and selective nonsteroidal aromatase inhibitors: synthesis, biological evaluation and structure-activity relationships investigation. J Med Chem. 2010 Jul 22;53(14):5347-51. DM6FMO1 RU https://pubmed.ncbi.nlm.nih.gov/20568782 DM8KZQN DI DM8KZQN DM8KZQN DN 4-Imidazol-1-ylmethyl-3-nitroxanthen-9-one DM8KZQN MI TTSZLWK DM8KZQN MN Aromatase (CYP19A1) DM8KZQN MT DTT DM8KZQN MA Inhibitor DM8KZQN RN Novel highly potent and selective nonsteroidal aromatase inhibitors: synthesis, biological evaluation and structure-activity relationships investigation. J Med Chem. 2010 Jul 22;53(14):5347-51. DM8KZQN RU https://pubmed.ncbi.nlm.nih.gov/20568782 DMVUSMP DI DMVUSMP DMVUSMP DN 4-Imidazol-1-ylmethylthioxanthen-9-one DMVUSMP MI TTSZLWK DMVUSMP MN Aromatase (CYP19A1) DMVUSMP MT DTT DMVUSMP MA Inhibitor DMVUSMP RN Novel highly potent and selective nonsteroidal aromatase inhibitors: synthesis, biological evaluation and structure-activity relationships investigation. J Med Chem. 2010 Jul 22;53(14):5347-51. DMVUSMP RU https://pubmed.ncbi.nlm.nih.gov/20568782 DMM8HK0 DI DMM8HK0 DMM8HK0 DN 4-Imidazol-1-ylmethylxanthen-9-one DMM8HK0 MI TTSZLWK DMM8HK0 MN Aromatase (CYP19A1) DMM8HK0 MT DTT DMM8HK0 MA Inhibitor DMM8HK0 RN Novel highly potent and selective nonsteroidal aromatase inhibitors: synthesis, biological evaluation and structure-activity relationships investigation. J Med Chem. 2010 Jul 22;53(14):5347-51. DMM8HK0 RU https://pubmed.ncbi.nlm.nih.gov/20568782 DMFRCQS DI DMFRCQS DMFRCQS DN 4-Indan-(1E)-ylidenemethyl-pyridine DMFRCQS MI TTSZLWK DMFRCQS MN Aromatase (CYP19A1) DMFRCQS MT DTT DMFRCQS MA Inhibitor DMFRCQS RN Synthesis and evaluation of (pyridylmethylene)tetrahydronaphthalenes/-indanes and structurally modified derivatives: potent and selective inhibitor... J Med Chem. 2005 Mar 10;48(5):1563-75. DMFRCQS RU https://pubmed.ncbi.nlm.nih.gov/15743198 DM25DR7 DI DM25DR7 DM25DR7 DN 4-Indan-(1Z)-ylidenemethyl-pyridine DM25DR7 MI TTSZLWK DM25DR7 MN Aromatase (CYP19A1) DM25DR7 MT DTT DM25DR7 MA Inhibitor DM25DR7 RN Synthesis and evaluation of (pyridylmethylene)tetrahydronaphthalenes/-indanes and structurally modified derivatives: potent and selective inhibitor... J Med Chem. 2005 Mar 10;48(5):1563-75. DM25DR7 RU https://pubmed.ncbi.nlm.nih.gov/15743198 DM25DR7 DI DM25DR7 DM25DR7 DN 4-Indan-(1Z)-ylidenemethyl-pyridine DM25DR7 MI TTIQUX7 DM25DR7 MN Steroid 11-beta-hydroxylase (CYP11B1) DM25DR7 MT DTT DM25DR7 MA Inhibitor DM25DR7 RN Synthesis and evaluation of (pyridylmethylene)tetrahydronaphthalenes/-indanes and structurally modified derivatives: potent and selective inhibitor... J Med Chem. 2005 Mar 10;48(5):1563-75. DM25DR7 RU https://pubmed.ncbi.nlm.nih.gov/15743198 DM25DR7 DI DM25DR7 DM25DR7 DN 4-Indan-(1Z)-ylidenemethyl-pyridine DM25DR7 MI TTRA5BZ DM25DR7 MN Steroid 17-alpha-monooxygenase (S17AH) DM25DR7 MT DTT DM25DR7 MA Inhibitor DM25DR7 RN Synthesis and evaluation of (pyridylmethylene)tetrahydronaphthalenes/-indanes and structurally modified derivatives: potent and selective inhibitor... J Med Chem. 2005 Mar 10;48(5):1563-75. DM25DR7 RU https://pubmed.ncbi.nlm.nih.gov/15743198 DM6YON7 DI DM6YON7 DM6YON7 DN 4-Indan-1-ylmethyl-phenylamine DM6YON7 MI TTJS8PY DM6YON7 MN 5-HT 6 receptor (HTR6) DM6YON7 MT DTT DM6YON7 MA Inhibitor DM6YON7 RN Binding of isotryptamines and indenes at h5-HT6 serotonin receptors. Bioorg Med Chem Lett. 2005 Apr 15;15(8):1987-91. DM6YON7 RU https://pubmed.ncbi.nlm.nih.gov/15808453 DM23E0R DI DM23E0R DM23E0R DN 4-Inden-(1E)-ylidenemethyl-phenylamine DM23E0R MI TTJS8PY DM23E0R MN 5-HT 6 receptor (HTR6) DM23E0R MT DTT DM23E0R MA Inhibitor DM23E0R RN Binding of isotryptamines and indenes at h5-HT6 serotonin receptors. Bioorg Med Chem Lett. 2005 Apr 15;15(8):1987-91. DM23E0R RU https://pubmed.ncbi.nlm.nih.gov/15808453 DMG9JSK DI DMG9JSK DMG9JSK DN 4-Indol-1-ylmethyl-benzamidine DMG9JSK MI TT2WR1T DMG9JSK MN Cationic trypsinogen (PRSS1) DMG9JSK MT DTT DMG9JSK MA Inhibitor DMG9JSK RN Aromatic amidines: comparison of their ability to block respiratory syncytial virus induced cell fusion and to inhibit plasmin, urokinase, thrombin... J Med Chem. 1983 Feb;26(2):294-8. DMG9JSK RU https://pubmed.ncbi.nlm.nih.gov/6219223 DMKZQ3I DI DMKZQ3I DMKZQ3I DN 4-iodo-1H-indazole DMKZQ3I MI TTZUFI5 DMKZQ3I MN Nitric-oxide synthase brain (NOS1) DMKZQ3I MT DTT DMKZQ3I MA Inhibitor DMKZQ3I RN 4-substituted indazoles as new inhibitors of neuronal nitric oxide synthase. Bioorg Med Chem Lett. 2007 Jun 1;17(11):3177-80. DMKZQ3I RU https://pubmed.ncbi.nlm.nih.gov/17395463 DMIPENJ DI DMIPENJ DMIPENJ DN 4-Iodo-2,6-diisopropyl-phenol DMIPENJ MI TTNJYV2 DMIPENJ MN Gamma-aminobutyric acid receptor (GAR) DMIPENJ MT DTT DMIPENJ MA Inhibitor DMIPENJ RN Propofol analogues. Synthesis, relationships between structure and affinity at GABAA receptor in rat brain, and differential electrophysiological p... J Med Chem. 1998 May 21;41(11):1846-54. DMIPENJ RU https://pubmed.ncbi.nlm.nih.gov/9599235 DMC8D4R DI DMC8D4R DMC8D4R DN 4-Iodo-6-nitro-2-piperazin-1-yl-quinoline DMC8D4R MI TT3ROYC DMC8D4R MN Serotonin transporter (SERT) DMC8D4R MT DTT DMC8D4R MA Inhibitor DMC8D4R RN Syntheses and binding affinities of 6-nitroquipazine analogues for serotonin transporter. Part 2: 4-substituted 6-nitroquipazines. Bioorg Med Chem Lett. 2002 Mar 11;12(5):811-5. DMC8D4R RU https://pubmed.ncbi.nlm.nih.gov/11859009 DMYNVLZ DI DMYNVLZ DMYNVLZ DN 4-iodo-6-phenylpyrimidine DMYNVLZ MI TT6804T DMYNVLZ MN MIF messenger RNA (MIF mRNA) DMYNVLZ MT DTT DMYNVLZ MA Inhibitor DMYNVLZ RN Optimization of N-benzyl-benzoxazol-2-ones as receptor antagonists of macrophage migration inhibitory factor (MIF). Bioorg Med Chem Lett. 2010 Oct 1;20(19):5811-4. DMYNVLZ RU https://pubmed.ncbi.nlm.nih.gov/20728358 DMFSH2I DI DMFSH2I DMFSH2I DN 4-iodo-acetamido phenylboronic acid DMFSH2I MI TTHI19T DMFSH2I MN Staphylococcus Beta-lactamase (Stap-coc blaZ) DMFSH2I MT DTT DMFSH2I MA Inhibitor DMFSH2I RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMFSH2I RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMXAEGF DI DMXAEGF DMXAEGF DN 4-iodobenzo[b]thiophene 2-carboxamidine DMXAEGF MI TT6L509 DMXAEGF MN Coagulation factor IIa (F2) DMXAEGF MT DTT DMXAEGF MA Inhibitor DMXAEGF RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DMXAEGF RU https://pubmed.ncbi.nlm.nih.gov/10592235 DMXAEGF DI DMXAEGF DMXAEGF DN 4-iodobenzo[b]thiophene 2-carboxamidine DMXAEGF MI TTFEZ5Q DMXAEGF MN Coagulation factor IX (F9) DMXAEGF MT DTT DMXAEGF MA Inhibitor DMXAEGF RN Studies of benzothiophene template as potent factor IXa (FIXa) inhibitors in thrombosis. J Med Chem. 2010 Feb 25;53(4):1465-72. DMXAEGF RU https://pubmed.ncbi.nlm.nih.gov/20121198 DMXAEGF DI DMXAEGF DMXAEGF DN 4-iodobenzo[b]thiophene 2-carboxamidine DMXAEGF MI TTGY7WI DMXAEGF MN Urokinase-type plasminogen activator (PLAU) DMXAEGF MT DTT DMXAEGF MA Inhibitor DMXAEGF RN Structural basis for selectivity of a small molecule, S1-binding, submicromolar inhibitor of urokinase-type plasminogen activator. Chem Biol. 2000 Apr;7(4):299-312. DMXAEGF RU https://pubmed.ncbi.nlm.nih.gov/10779411 DMJMOAI DI DMJMOAI DMJMOAI DN 4-iodophenyl-alaninyl-(S)-2-cyano-pyrrolidine DMJMOAI MI TTDIGC1 DMJMOAI MN Dipeptidyl peptidase 4 (DPP-4) DMJMOAI MT DTT DMJMOAI MA Inhibitor DMJMOAI RN Discovery, SAR, and X-ray structure of novel biaryl-based dipeptidyl peptidase IV inhibitors. Bioorg Med Chem Lett. 2006 Jan 1;16(1):123-8. DMJMOAI RU https://pubmed.ncbi.nlm.nih.gov/16236500 DMF3CLX DI DMF3CLX DMF3CLX DN 4-Iodopyrazole DMF3CLX MI TTBK0PU DMF3CLX MN Mycobacterium Cytochrome p450 121 (MycB cyp121) DMF3CLX MT DTT DMF3CLX MA Inhibitor DMF3CLX RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMF3CLX RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMQ95EG DI DMQ95EG DMQ95EG DN 4-Iodyl-benzoic acid DMQ95EG MI TTELIN2 DMQ95EG MN PTPN1 messenger RNA (PTPN1 mRNA) DMQ95EG MT DTT DMQ95EG MA Inhibitor DMQ95EG RN Periodinates: a new class of protein tyrosine phosphatase inhibitors. Bioorg Med Chem Lett. 1999 Feb 8;9(3):353-6. DMQ95EG RU https://pubmed.ncbi.nlm.nih.gov/10091683 DM7F38J DI DM7F38J DM7F38J DN 4-isopropyl-2-(phenoxymethyl)morpholine DM7F38J MI TT9JNIC DM7F38J MN Histamine H3 receptor (H3R) DM7F38J MT DTT DM7F38J MA Inhibitor DM7F38J RN 2-Aryloxymethylmorpholine histamine H(3) antagonists. Bioorg Med Chem Lett. 2008 Nov 1;18(21):5796-9. DM7F38J RU https://pubmed.ncbi.nlm.nih.gov/18922693 DMW1T93 DI DMW1T93 DMW1T93 DN 4-isopropyl-N-(naphthalen-1-yl)thiazol-2-amine DMW1T93 MI TT7HQD0 DMW1T93 MN C-C chemokine receptor type 4 (CCR4) DMW1T93 MT DTT DMW1T93 MA Inhibitor DMW1T93 RN Optimization of 2-aminothiazole derivatives as CCR4 antagonists. Bioorg Med Chem Lett. 2006 May 15;16(10):2800-3. DMW1T93 RU https://pubmed.ncbi.nlm.nih.gov/16497499 DMMDGR2 DI DMMDGR2 DMMDGR2 DN 4-ISOPROPYLPHENSERINE DMMDGR2 MI TT1RS9F DMMDGR2 MN Acetylcholinesterase (AChE) DMMDGR2 MT DTT DMMDGR2 MA Inhibitor DMMDGR2 RN Design, synthesis, evaluation and QSAR analysis of N(1)-substituted norcymserine derivatives as selective butyrylcholinesterase inhibitors. Bioorg Med Chem Lett. 2010 Mar 1;20(5):1718-20. DMMDGR2 RU https://pubmed.ncbi.nlm.nih.gov/20137934 DMMDGR2 DI DMMDGR2 DMMDGR2 DN 4-ISOPROPYLPHENSERINE DMMDGR2 MI TTEB0GD DMMDGR2 MN Cholinesterase (BCHE) DMMDGR2 MT DTT DMMDGR2 MA Inhibitor DMMDGR2 RN A new therapeutic target in Alzheimer's disease treatment: attention to butyrylcholinesterase. Curr Med Res Opin. 2001;17(3):159-65. DMMDGR2 RU https://pubmed.ncbi.nlm.nih.gov/11900310 DMVTEOQ DI DMVTEOQ DMVTEOQ DN 4-Isopropyl-pyrrolidin-(2Z)-ylideneamine DMVTEOQ MI TTZUFI5 DMVTEOQ MN Nitric-oxide synthase brain (NOS1) DMVTEOQ MT DTT DMVTEOQ MA Inhibitor DMVTEOQ RN Evaluation of pyrrolidin-2-imines and 1,3-thiazolidin-2-imines as inhibitors of nitric oxide synthase. Bioorg Med Chem Lett. 2004 Sep 6;14(17):4539-44. DMVTEOQ RU https://pubmed.ncbi.nlm.nih.gov/15357988 DMVTEOQ DI DMVTEOQ DMVTEOQ DN 4-Isopropyl-pyrrolidin-(2Z)-ylideneamine DMVTEOQ MI TTF10I9 DMVTEOQ MN Nitric-oxide synthase inducible (NOS2) DMVTEOQ MT DTT DMVTEOQ MA Inhibitor DMVTEOQ RN Evaluation of pyrrolidin-2-imines and 1,3-thiazolidin-2-imines as inhibitors of nitric oxide synthase. Bioorg Med Chem Lett. 2004 Sep 6;14(17):4539-44. DMVTEOQ RU https://pubmed.ncbi.nlm.nih.gov/15357988 DMBK67H DI DMBK67H DMBK67H DN 4-isothiocyanatobenzenesulfonamide DMBK67H MI TTHQPL7 DMBK67H MN Carbonic anhydrase I (CA-I) DMBK67H MT DTT DMBK67H MA Inhibitor DMBK67H RN Carbonic anhydrase inhibitors: the first on-resin screening of a 4-sulfamoylphenylthiourea library. J Med Chem. 2004 Oct 7;47(21):5224-9. DMBK67H RU https://pubmed.ncbi.nlm.nih.gov/15456265 DMBK67H DI DMBK67H DMBK67H DN 4-isothiocyanatobenzenesulfonamide DMBK67H MI TTANPDJ DMBK67H MN Carbonic anhydrase II (CA-II) DMBK67H MT DTT DMBK67H MA Inhibitor DMBK67H RN Carbonic anhydrase inhibitors: the first on-resin screening of a 4-sulfamoylphenylthiourea library. J Med Chem. 2004 Oct 7;47(21):5224-9. DMBK67H RU https://pubmed.ncbi.nlm.nih.gov/15456265 DMNCVIP DI DMNCVIP DMNCVIP DN 4-MA DMNCVIP MI TTZT9R2 DMNCVIP MN Hydroxysteroid dehydrogenase 3-beta (HSD3B) DMNCVIP MT DTT DMNCVIP MA Inhibitor DMNCVIP RN Activity and inhibition of 3-beta-hydroxysteroid dehydrogenase/delta-5-4-isomerase in human skin. Skin Pharmacol. 1997;10(3):160-8. DMNCVIP RU https://pubmed.ncbi.nlm.nih.gov/9287397 DMPH4C8 DI DMPH4C8 DMPH4C8 DN 4-Methanesulfonylamino-benzenesulfonamide DMPH4C8 MI TTHQPL7 DMPH4C8 MN Carbonic anhydrase I (CA-I) DMPH4C8 MT DTT DMPH4C8 MA Inhibitor DMPH4C8 RN Carbonic anhydrase inhibitors: inhibition of the tumor-associated isozymes IX and XII with a library of aromatic and heteroaromatic sulfonamides. Bioorg Med Chem Lett. 2005 Nov 1;15(21):4862-6. DMPH4C8 RU https://pubmed.ncbi.nlm.nih.gov/16168653 DMPH4C8 DI DMPH4C8 DMPH4C8 DN 4-Methanesulfonylamino-benzenesulfonamide DMPH4C8 MI TTANPDJ DMPH4C8 MN Carbonic anhydrase II (CA-II) DMPH4C8 MT DTT DMPH4C8 MA Inhibitor DMPH4C8 RN Carbonic anhydrase inhibitors: inhibition of the tumor-associated isozymes IX and XII with a library of aromatic and heteroaromatic sulfonamides. Bioorg Med Chem Lett. 2005 Nov 1;15(21):4862-6. DMPH4C8 RU https://pubmed.ncbi.nlm.nih.gov/16168653 DMPH4C8 DI DMPH4C8 DMPH4C8 DN 4-Methanesulfonylamino-benzenesulfonamide DMPH4C8 MI TT2LVK8 DMPH4C8 MN Carbonic anhydrase IX (CA-IX) DMPH4C8 MT DTT DMPH4C8 MA Inhibitor DMPH4C8 RN Carbonic anhydrase inhibitors: inhibition of the tumor-associated isozymes IX and XII with a library of aromatic and heteroaromatic sulfonamides. Bioorg Med Chem Lett. 2005 Nov 1;15(21):4862-6. DMPH4C8 RU https://pubmed.ncbi.nlm.nih.gov/16168653 DMPH4C8 DI DMPH4C8 DMPH4C8 DN 4-Methanesulfonylamino-benzenesulfonamide DMPH4C8 MI TTSYM0R DMPH4C8 MN Carbonic anhydrase XII (CA-XII) DMPH4C8 MT DTT DMPH4C8 MA Inhibitor DMPH4C8 RN Carbonic anhydrase inhibitors: inhibition of the tumor-associated isozymes IX and XII with a library of aromatic and heteroaromatic sulfonamides. Bioorg Med Chem Lett. 2005 Nov 1;15(21):4862-6. DMPH4C8 RU https://pubmed.ncbi.nlm.nih.gov/16168653 DM97B2G DI DM97B2G DM97B2G DN 4-Methoxy-2-phenyl-2H-pyrazolo[4,3-c]quinoline DM97B2G MI TTJFY5U DM97B2G MN Adenosine A3 receptor (ADORA3) DM97B2G MT DTT DM97B2G MA Inhibitor DM97B2G RN New 2-arylpyrazolo[4,3-c]quinoline derivatives as potent and selective human A3 adenosine receptor antagonists. J Med Chem. 2005 Jul 28;48(15):5001-8. DM97B2G RU https://pubmed.ncbi.nlm.nih.gov/16033279 DMJIX7H DI DMJIX7H DMJIX7H DN 4-Methoxy-3-pyridinesulfonamide DMJIX7H MI TTHQPL7 DMJIX7H MN Carbonic anhydrase I (CA-I) DMJIX7H MT DTT DMJIX7H MA Inhibitor DMJIX7H RN Carbonic anhydrase inhibitors: synthesis and inhibition of the human cytosolic isozymes I and II and transmembrane isozymes IX, XII (cancer-associa... Eur J Med Chem. 2010 Jun;45(6):2396-404. DMJIX7H RU https://pubmed.ncbi.nlm.nih.gov/20202722 DMJIX7H DI DMJIX7H DMJIX7H DN 4-Methoxy-3-pyridinesulfonamide DMJIX7H MI TTANPDJ DMJIX7H MN Carbonic anhydrase II (CA-II) DMJIX7H MT DTT DMJIX7H MA Inhibitor DMJIX7H RN Carbonic anhydrase inhibitors: synthesis and inhibition of the human cytosolic isozymes I and II and transmembrane isozymes IX, XII (cancer-associa... Eur J Med Chem. 2010 Jun;45(6):2396-404. DMJIX7H RU https://pubmed.ncbi.nlm.nih.gov/20202722 DMJIX7H DI DMJIX7H DMJIX7H DN 4-Methoxy-3-pyridinesulfonamide DMJIX7H MI TT2LVK8 DMJIX7H MN Carbonic anhydrase IX (CA-IX) DMJIX7H MT DTT DMJIX7H MA Inhibitor DMJIX7H RN Carbonic anhydrase inhibitors: synthesis and inhibition of the human cytosolic isozymes I and II and transmembrane isozymes IX, XII (cancer-associa... Eur J Med Chem. 2010 Jun;45(6):2396-404. DMJIX7H RU https://pubmed.ncbi.nlm.nih.gov/20202722 DMJIX7H DI DMJIX7H DMJIX7H DN 4-Methoxy-3-pyridinesulfonamide DMJIX7H MI TTSYM0R DMJIX7H MN Carbonic anhydrase XII (CA-XII) DMJIX7H MT DTT DMJIX7H MA Inhibitor DMJIX7H RN Carbonic anhydrase inhibitors: synthesis and inhibition of the human cytosolic isozymes I and II and transmembrane isozymes IX, XII (cancer-associa... Eur J Med Chem. 2010 Jun;45(6):2396-404. DMJIX7H RU https://pubmed.ncbi.nlm.nih.gov/20202722 DM5FRV2 DI DM5FRV2 DM5FRV2 DN 4'-Methoxy-5,3'-dipropyl-biphenyl-2ol DM5FRV2 MI TTSJ6Q4 DM5FRV2 MN LOX-5 messenger RNA (ALOX5 mRNA) DM5FRV2 MT DTT DM5FRV2 MA Inhibitor DM5FRV2 RN Design and synthesis of ten biphenyl-neolignan derivatives and their in vitro inhibitory potency against cyclooxygenase-1/2 activity and 5-lipoxyge... Bioorg Med Chem. 2009 Jul 1;17(13):4459-65. DM5FRV2 RU https://pubmed.ncbi.nlm.nih.gov/19481465 DM5FRV2 DI DM5FRV2 DM5FRV2 DN 4'-Methoxy-5,3'-dipropyl-biphenyl-2ol DM5FRV2 MI TT8NGED DM5FRV2 MN Prostaglandin G/H synthase 1 (COX-1) DM5FRV2 MT DTT DM5FRV2 MA Inhibitor DM5FRV2 RN Design and synthesis of ten biphenyl-neolignan derivatives and their in vitro inhibitory potency against cyclooxygenase-1/2 activity and 5-lipoxyge... Bioorg Med Chem. 2009 Jul 1;17(13):4459-65. DM5FRV2 RU https://pubmed.ncbi.nlm.nih.gov/19481465 DMID40H DI DMID40H DMID40H DN 4-Methoxy-5-phenyl-6-thia-10b-aza-benzo[e]azulene DMID40H MI TTPTXIN DMID40H MN Translocator protein (TSPO) DMID40H MT DTT DMID40H MA Inhibitor DMID40H RN A concerted study using binding measurements, X-ray structural data, and molecular modeling on the stereochemical features responsible for the affi... J Med Chem. 1995 Nov 10;38(23):4730-8. DMID40H RU https://pubmed.ncbi.nlm.nih.gov/7473601 DM54A3W DI DM54A3W DM54A3W DN 4-methoxy-9-aminomethyl-9,10-dihydroanthracene DM54A3W MI TTJQOD7 DM54A3W MN 5-HT 2A receptor (HTR2A) DM54A3W MT DTT DM54A3W MA Inhibitor DM54A3W RN Methoxy-substituted 9-aminomethyl-9,10-dihydroanthracene (AMDA) derivatives exhibit differential binding affinities at the 5-HT(2A) receptor. Bioorg Med Chem Lett. 2008 Oct 1;18(19):5268-71. DM54A3W RU https://pubmed.ncbi.nlm.nih.gov/18774714 DMVFLCM DI DMVFLCM DMVFLCM DN 4-Methoxybenzenemethanethiol DMVFLCM MI TTZJYKH DMVFLCM MN Indoleamine 2,3-dioxygenase 1 (IDO1) DMVFLCM MT DTT DMVFLCM MA Inhibitor DMVFLCM RN S-benzylisothiourea derivatives as small-molecule inhibitors of indoleamine-2,3-dioxygenase. Bioorg Med Chem Lett. 2010 Sep 1;20(17):5126-9. DMVFLCM RU https://pubmed.ncbi.nlm.nih.gov/20688518 DMCS83F DI DMCS83F DMCS83F DN 4-Methoxymethyl-3,6-dipropoxy-9H-beta-carboline DMCS83F MI TT1MPAY DMCS83F MN GABA(A) receptor alpha-1 (GABRA1) DMCS83F MT DTT DMCS83F MA Inhibitor DMCS83F RN Synthesis and evaluation of analogues of the partial agonist 6-(propyloxy)-4-(methoxymethyl)-beta-carboline-3-carboxylic acid ethyl ester (6-PBC) a... J Med Chem. 1998 Jul 2;41(14):2537-52. DMCS83F RU https://pubmed.ncbi.nlm.nih.gov/9651158 DMCS83F DI DMCS83F DMCS83F DN 4-Methoxymethyl-3,6-dipropoxy-9H-beta-carboline DMCS83F MI TTNJYV2 DMCS83F MN Gamma-aminobutyric acid receptor (GAR) DMCS83F MT DTT DMCS83F MA Inhibitor DMCS83F RN Synthesis and evaluation of analogues of the partial agonist 6-(propyloxy)-4-(methoxymethyl)-beta-carboline-3-carboxylic acid ethyl ester (6-PBC) a... J Med Chem. 1998 Jul 2;41(14):2537-52. DMCS83F RU https://pubmed.ncbi.nlm.nih.gov/9651158 DMF079L DI DMF079L DMF079L DN 4-methoxy-N'-(2-phenylacetyl)benzohydrazide DMF079L MI TTPLTSQ DMF079L MN Neutrophil elastase (NE) DMF079L MT DTT DMF079L MA Inhibitor DMF079L RN N-benzoylpyrazoles are novel small-molecule inhibitors of human neutrophil elastase. J Med Chem. 2007 Oct 4;50(20):4928-38. DMF079L RU https://pubmed.ncbi.nlm.nih.gov/17850059 DMF079L DI DMF079L DMF079L DN 4-methoxy-N'-(2-phenylacetyl)benzohydrazide DMF079L MI TTGY7WI DMF079L MN Urokinase-type plasminogen activator (PLAU) DMF079L MT DTT DMF079L MA Inhibitor DMF079L RN N-benzoylpyrazoles are novel small-molecule inhibitors of human neutrophil elastase. J Med Chem. 2007 Oct 4;50(20):4928-38. DMF079L RU https://pubmed.ncbi.nlm.nih.gov/17850059 DMFKN1M DI DMFKN1M DMFKN1M DN 4-Methoxy-N-(3-phenyl-isoquinolin-1-yl)-benzamide DMFKN1M MI TTK25J1 DMFKN1M MN Adenosine A1 receptor (ADORA1) DMFKN1M MT DTT DMFKN1M MA Inhibitor DMFKN1M RN Substituted 4-phenyl-2-(phenylcarboxamido)-1,3-thiazole derivatives as antagonists for the adenosine A(1) receptor. Bioorg Med Chem Lett. 2001 Aug 6;11(15):2017-9. DMFKN1M RU https://pubmed.ncbi.nlm.nih.gov/11454470 DMFKN1M DI DMFKN1M DMFKN1M DN 4-Methoxy-N-(3-phenyl-isoquinolin-1-yl)-benzamide DMFKN1M MI TTJFY5U DMFKN1M MN Adenosine A3 receptor (ADORA3) DMFKN1M MT DTT DMFKN1M MA Inhibitor DMFKN1M RN Substituted 4-phenyl-2-(phenylcarboxamido)-1,3-thiazole derivatives as antagonists for the adenosine A(1) receptor. Bioorg Med Chem Lett. 2001 Aug 6;11(15):2017-9. DMFKN1M RU https://pubmed.ncbi.nlm.nih.gov/11454470 DMPQKGY DI DMPQKGY DMPQKGY DN 4-methoxy-N-(thiazol-2-yl)benzamide DMPQKGY MI TTSJ6Q4 DMPQKGY MN LOX-5 messenger RNA (ALOX5 mRNA) DMPQKGY MT DTT DMPQKGY MA Inhibitor DMPQKGY RN Identification of natural-product-derived inhibitors of 5-lipoxygenase activity by ligand-based virtual screening. J Med Chem. 2007 May 31;50(11):2640-6. DMPQKGY RU https://pubmed.ncbi.nlm.nih.gov/17461565 DMBS61O DI DMBS61O DMBS61O DN 4-methoxynaphthalen-1-amine DMBS61O MI TTZJYKH DMBS61O MN Indoleamine 2,3-dioxygenase 1 (IDO1) DMBS61O MT DTT DMBS61O MA Inhibitor DMBS61O RN Rational design of indoleamine 2,3-dioxygenase inhibitors. J Med Chem. 2010 Feb 11;53(3):1172-89. DMBS61O RU https://pubmed.ncbi.nlm.nih.gov/20055453 DM739SQ DI DM739SQ DM739SQ DN 4-methoxyphenyl 1-(4-butoxyphenyl)propylcarbamate DM739SQ MI TTDP1UC DM739SQ MN Fatty acid amide hydrolase (FAAH) DM739SQ MT DTT DM739SQ MA Inhibitor DM739SQ RN Oxime carbamate--discovery of a series of novel FAAH inhibitors. Bioorg Med Chem Lett. 2010 Feb 1;20(3):1272-7. DM739SQ RU https://pubmed.ncbi.nlm.nih.gov/20036536 DM3L76R DI DM3L76R DM3L76R DN 4-methoxyphenyl 10H-phenothiazine-10-carboxylate DM3L76R MI TTEB0GD DM3L76R MN Cholinesterase (BCHE) DM3L76R MT DTT DM3L76R MA Inhibitor DM3L76R RN Carbamates with differential mechanism of inhibition toward acetylcholinesterase and butyrylcholinesterase. J Med Chem. 2008 Jul 24;51(14):4200-12. DM3L76R RU https://pubmed.ncbi.nlm.nih.gov/18570368 DMP5YFQ DI DMP5YFQ DMP5YFQ DN 4-methoxyphenylboronic acid DMP5YFQ MI TTUNARX DMP5YFQ MN Carbonic anhydrase (CA) DMP5YFQ MT DTT DMP5YFQ MA Inhibitor DMP5YFQ RN Carbonic anhydrase inhibitors. Inhibition of the fungal beta-carbonic anhydrases from Candida albicans and Cryptococcus neoformans with boronic acids. Bioorg Med Chem Lett. 2009 May 15;19(10):2642-5. DMP5YFQ RU https://pubmed.ncbi.nlm.nih.gov/19375309 DMP5YFQ DI DMP5YFQ DMP5YFQ DN 4-methoxyphenylboronic acid DMP5YFQ MI TTHQPL7 DMP5YFQ MN Carbonic anhydrase I (CA-I) DMP5YFQ MT DTT DMP5YFQ MA Inhibitor DMP5YFQ RN Carbonic anhydrase inhibitors. Inhibition of the fungal beta-carbonic anhydrases from Candida albicans and Cryptococcus neoformans with boronic acids. Bioorg Med Chem Lett. 2009 May 15;19(10):2642-5. DMP5YFQ RU https://pubmed.ncbi.nlm.nih.gov/19375309 DMP5YFQ DI DMP5YFQ DMP5YFQ DN 4-methoxyphenylboronic acid DMP5YFQ MI TTANPDJ DMP5YFQ MN Carbonic anhydrase II (CA-II) DMP5YFQ MT DTT DMP5YFQ MA Inhibitor DMP5YFQ RN Carbonic anhydrase inhibitors. Inhibition of the fungal beta-carbonic anhydrases from Candida albicans and Cryptococcus neoformans with boronic acids. Bioorg Med Chem Lett. 2009 May 15;19(10):2642-5. DMP5YFQ RU https://pubmed.ncbi.nlm.nih.gov/19375309 DMP5YFQ DI DMP5YFQ DMP5YFQ DN 4-methoxyphenylboronic acid DMP5YFQ MI TTDP1UC DMP5YFQ MN Fatty acid amide hydrolase (FAAH) DMP5YFQ MT DTT DMP5YFQ MA Inhibitor DMP5YFQ RN Discovery of boronic acids as novel and potent inhibitors of fatty acid amide hydrolase. J Med Chem. 2008 Nov 27;51(22):7057-60. DMP5YFQ RU https://pubmed.ncbi.nlm.nih.gov/18983140 DMVW8KN DI DMVW8KN DMVW8KN DN 4-methoxyphenylsulfamide DMVW8KN MI TTANPDJ DMVW8KN MN Carbonic anhydrase II (CA-II) DMVW8KN MT DTT DMVW8KN MA Inhibitor DMVW8KN RN Inhibition of carbonic anhydrase-II by sulfamate and sulfamide groups: an investigation involving direct thermodynamic binding measurements. J Med Chem. 2006 Jun 15;49(12):3496-500. DMVW8KN RU https://pubmed.ncbi.nlm.nih.gov/16759092 DM2IZA3 DI DM2IZA3 DM2IZA3 DN 4-Methyl-1,1':4',1''-terphenyl-3,4''-diol DM2IZA3 MI TTIWB6L DM2IZA3 MN Estradiol 17 beta-dehydrogenase 1 (17-beta-HSD1) DM2IZA3 MT DTT DM2IZA3 MA Inhibitor DM2IZA3 RN New insights into the SAR and binding modes of bis(hydroxyphenyl)thiophenes and -benzenes: influence of additional substituents on 17beta-hydroxyst... J Med Chem. 2009 Nov 12;52(21):6724-43. DM2IZA3 RU https://pubmed.ncbi.nlm.nih.gov/19831396 DMKRHQ3 DI DMKRHQ3 DMKRHQ3 DN 4-methyl-2H-benzofuro[3,2-g]chromen-2-one DMKRHQ3 MI TT3WG5C DMKRHQ3 MN Monoamine oxidase type A (MAO-A) DMKRHQ3 MT DTT DMKRHQ3 MA Inhibitor DMKRHQ3 RN A QSAR model for in silico screening of MAO-A inhibitors. Prediction, synthesis, and biological assay of novel coumarins. J Med Chem. 2006 Feb 9;49(3):1149-56. DMKRHQ3 RU https://pubmed.ncbi.nlm.nih.gov/16451079 DMH6QZO DI DMH6QZO DMH6QZO DN 4-Methyl-3-(2-oxo-azetidin-1-yl)-benzoic acid DMH6QZO MI TTHI19T DMH6QZO MN Staphylococcus Beta-lactamase (Stap-coc blaZ) DMH6QZO MT DTT DMH6QZO MA Inhibitor DMH6QZO RN N-aryl 3-halogenated azetidin-2-ones and benzocarbacephems, inhibitors of beta-lactamases. J Med Chem. 1988 Feb;31(2):370-4. DMH6QZO RU https://pubmed.ncbi.nlm.nih.gov/3257523 DM5FWYG DI DM5FWYG DM5FWYG DN 4-Methyl-3,6-dihydro-1H-pyridin-(2Z)-ylideneamine DM5FWYG MI TTCM4B3 DM5FWYG MN Nitric-oxide synthase endothelial (NOS3) DM5FWYG MT DTT DM5FWYG MA Inhibitor DM5FWYG RN Design and synthesis of orally bioavailable inhibitors of inducible nitric oxide synthase. Part 1: synthesis and biological evaluation of dihydropy... Bioorg Med Chem Lett. 2002 Sep 2;12(17):2291-4. DM5FWYG RU https://pubmed.ncbi.nlm.nih.gov/12161118 DMV19HC DI DMV19HC DMV19HC DN 4-Methyl-5-(4-piperidyl)isothiazol-3-ol DMV19HC MI TT1MPAY DMV19HC MN GABA(A) receptor alpha-1 (GABRA1) DMV19HC MT DTT DMV19HC MA Inhibitor DMV19HC RN Potent 4-arylalkyl-substituted 3-isothiazolol GABA(A) competitive/noncompetitive antagonists: synthesis and pharmacology. J Med Chem. 2006 Feb 23;49(4):1388-96. DMV19HC RU https://pubmed.ncbi.nlm.nih.gov/16480274 DMV19HC DI DMV19HC DMV19HC DN 4-Methyl-5-(4-piperidyl)isothiazol-3-ol DMV19HC MI TT06RH5 DMV19HC MN GABA(A) receptor gamma-2 (GABRG2) DMV19HC MT DTT DMV19HC MA Inhibitor DMV19HC RN Potent 4-arylalkyl-substituted 3-isothiazolol GABA(A) competitive/noncompetitive antagonists: synthesis and pharmacology. J Med Chem. 2006 Feb 23;49(4):1388-96. DMV19HC RU https://pubmed.ncbi.nlm.nih.gov/16480274 DMV19HC DI DMV19HC DMV19HC DN 4-Methyl-5-(4-piperidyl)isothiazol-3-ol DMV19HC MI TTNJYV2 DMV19HC MN Gamma-aminobutyric acid receptor (GAR) DMV19HC MT DTT DMV19HC MA Inhibitor DMV19HC RN Potent 4-arylalkyl-substituted 3-isothiazolol GABA(A) competitive/noncompetitive antagonists: synthesis and pharmacology. J Med Chem. 2006 Feb 23;49(4):1388-96. DMV19HC RU https://pubmed.ncbi.nlm.nih.gov/16480274 DMUP8NS DI DMUP8NS DMUP8NS DN 4-Methyl-5,6-dihydro-1H-pyridin-(2Z)-ylideneamine DMUP8NS MI TTCM4B3 DMUP8NS MN Nitric-oxide synthase endothelial (NOS3) DMUP8NS MT DTT DMUP8NS MA Inhibitor DMUP8NS RN Design and synthesis of orally bioavailable inhibitors of inducible nitric oxide synthase. Part 1: synthesis and biological evaluation of dihydropy... Bioorg Med Chem Lett. 2002 Sep 2;12(17):2291-4. DMUP8NS RU https://pubmed.ncbi.nlm.nih.gov/12161118 DM7LPON DI DM7LPON DM7LPON DN 4-Methyl-5,6-dihydro-pyrido[1,2-a]quinolin-3-one DM7LPON MI TTTU72V DM7LPON MN Steroid 5-alpha-reductase 1 (SRD5A1) DM7LPON MT DTT DM7LPON MA Inhibitor DM7LPON RN Benzo[c]quinolizin-3-ones: a novel class of potent and selective nonsteroidal inhibitors of human steroid 5alpha-reductase 1. J Med Chem. 2000 Oct 5;43(20):3718-35. DM7LPON RU https://pubmed.ncbi.nlm.nih.gov/11020287 DM0ZA7T DI DM0ZA7T DM0ZA7T DN 4-Methyl-5-piperidin-4-yl-isoxazol-3-ol DM0ZA7T MI TTNJYV2 DM0ZA7T MN Gamma-aminobutyric acid receptor (GAR) DM0ZA7T MT DTT DM0ZA7T MA Inhibitor DM0ZA7T RN A novel class of potent 3-isoxazolol GABA(A) antagonists: design, synthesis, and pharmacology. J Med Chem. 2000 Dec 28;43(26):4930-3. DM0ZA7T RU https://pubmed.ncbi.nlm.nih.gov/11150163 DMN8Z3C DI DMN8Z3C DMN8Z3C DN 4-Methyl-5-propyl-pyrrolidin-(2Z)-ylideneamine DMN8Z3C MI TTZUFI5 DMN8Z3C MN Nitric-oxide synthase brain (NOS1) DMN8Z3C MT DTT DMN8Z3C MA Inhibitor DMN8Z3C RN Evaluation of pyrrolidin-2-imines and 1,3-thiazolidin-2-imines as inhibitors of nitric oxide synthase. Bioorg Med Chem Lett. 2004 Sep 6;14(17):4539-44. DMN8Z3C RU https://pubmed.ncbi.nlm.nih.gov/15357988 DMN8Z3C DI DMN8Z3C DMN8Z3C DN 4-Methyl-5-propyl-pyrrolidin-(2Z)-ylideneamine DMN8Z3C MI TTF10I9 DMN8Z3C MN Nitric-oxide synthase inducible (NOS2) DMN8Z3C MT DTT DMN8Z3C MA Inhibitor DMN8Z3C RN Evaluation of pyrrolidin-2-imines and 1,3-thiazolidin-2-imines as inhibitors of nitric oxide synthase. Bioorg Med Chem Lett. 2004 Sep 6;14(17):4539-44. DMN8Z3C RU https://pubmed.ncbi.nlm.nih.gov/15357988 DMW7YHS DI DMW7YHS DMW7YHS DN 4-Methyl-6-(2-methylprop-1-enyl)pyridin-2-amine DMW7YHS MI TTF10I9 DMW7YHS MN Nitric-oxide synthase inducible (NOS2) DMW7YHS MT DTT DMW7YHS MA Inhibitor DMW7YHS RN Design and synthesis of 2-amino-4-methylpyridine analogues as inhibitors for inducible nitric oxide synthase and in vivo evaluation of [18F]6-(2-fl... J Med Chem. 2009 Apr 23;52(8):2443-53. DMW7YHS RU https://pubmed.ncbi.nlm.nih.gov/19323559 DMY04D1 DI DMY04D1 DMY04D1 DN 4-methyl-6-propylpyridin-2-amine DMY04D1 MI TTZUFI5 DMY04D1 MN Nitric-oxide synthase brain (NOS1) DMY04D1 MT DTT DMY04D1 MA Inhibitor DMY04D1 RN Anchored plasticity opens doors for selective inhibitor design in nitric oxide synthase. Nat Chem Biol. 2008 Nov;4(11):700-7. DMY04D1 RU https://pubmed.ncbi.nlm.nih.gov/18849972 DMY04D1 DI DMY04D1 DMY04D1 DN 4-methyl-6-propylpyridin-2-amine DMY04D1 MI TTCM4B3 DMY04D1 MN Nitric-oxide synthase endothelial (NOS3) DMY04D1 MT DTT DMY04D1 MA Inhibitor DMY04D1 RN Anchored plasticity opens doors for selective inhibitor design in nitric oxide synthase. Nat Chem Biol. 2008 Nov;4(11):700-7. DMY04D1 RU https://pubmed.ncbi.nlm.nih.gov/18849972 DMY04D1 DI DMY04D1 DMY04D1 DN 4-methyl-6-propylpyridin-2-amine DMY04D1 MI TTF10I9 DMY04D1 MN Nitric-oxide synthase inducible (NOS2) DMY04D1 MT DTT DMY04D1 MA Inhibitor DMY04D1 RN Anchored plasticity opens doors for selective inhibitor design in nitric oxide synthase. Nat Chem Biol. 2008 Nov;4(11):700-7. DMY04D1 RU https://pubmed.ncbi.nlm.nih.gov/18849972 DM9K7CQ DI DM9K7CQ DM9K7CQ DN 4-methyl-7-(2-oxocyclopentyloxy)-2H-chromen-2-one DM9K7CQ MI TT3WG5C DM9K7CQ MN Monoamine oxidase type A (MAO-A) DM9K7CQ MT DTT DM9K7CQ MA Inhibitor DM9K7CQ RN Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors. J Med Chem. 2008 Nov 13;51(21):6740-51. DM9K7CQ RU https://pubmed.ncbi.nlm.nih.gov/18834112 DM9K7CQ DI DM9K7CQ DM9K7CQ DN 4-methyl-7-(2-oxocyclopentyloxy)-2H-chromen-2-one DM9K7CQ MI TTGP7BY DM9K7CQ MN Monoamine oxidase type B (MAO-B) DM9K7CQ MT DTT DM9K7CQ MA Inhibitor DM9K7CQ RN Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors. J Med Chem. 2008 Nov 13;51(21):6740-51. DM9K7CQ RU https://pubmed.ncbi.nlm.nih.gov/18834112 DM5XMI9 DI DM5XMI9 DM5XMI9 DN 4-Methylamino-benzenesulfonamide DM5XMI9 MI TTANPDJ DM5XMI9 MN Carbonic anhydrase II (CA-II) DM5XMI9 MT DTT DM5XMI9 MA Inhibitor DM5XMI9 RN Carbonic anhydrase inhibitors. Inhibition of the transmembrane isozyme XII with sulfonamides-a new target for the design of antitumor and antiglauc... Bioorg Med Chem Lett. 2005 Feb 15;15(4):963-9. DM5XMI9 RU https://pubmed.ncbi.nlm.nih.gov/15686894 DM5XMI9 DI DM5XMI9 DM5XMI9 DN 4-Methylamino-benzenesulfonamide DM5XMI9 MI TTSYM0R DM5XMI9 MN Carbonic anhydrase XII (CA-XII) DM5XMI9 MT DTT DM5XMI9 MA Inhibitor DM5XMI9 RN Carbonic anhydrase inhibitors. Inhibition of the transmembrane isozyme XII with sulfonamides-a new target for the design of antitumor and antiglauc... Bioorg Med Chem Lett. 2005 Feb 15;15(4):963-9. DM5XMI9 RU https://pubmed.ncbi.nlm.nih.gov/15686894 DMI1L6Q DI DMI1L6Q DMI1L6Q DN 4-methylaminomethyl-7-methoxycoumarin DMI1L6Q MI TTVG215 DMI1L6Q MN Debrisoquine 4-hydroxylase (CYP2D6) DMI1L6Q MT DTT DMI1L6Q MA Inhibitor DMI1L6Q RN Exploration of the amine terminus in a novel series of 1,2,4-triazolo-3-yl-azabicyclo[3.1.0]hexanes as selective dopamine D3 receptor antagonists. J Med Chem. 2010 Oct 14;53(19):7129-39. DMI1L6Q RU https://pubmed.ncbi.nlm.nih.gov/20839775 DM3S2P8 DI DM3S2P8 DM3S2P8 DN 4-Methylbenzenemethanethiol DM3S2P8 MI TTZJYKH DM3S2P8 MN Indoleamine 2,3-dioxygenase 1 (IDO1) DM3S2P8 MT DTT DM3S2P8 MA Inhibitor DM3S2P8 RN S-benzylisothiourea derivatives as small-molecule inhibitors of indoleamine-2,3-dioxygenase. Bioorg Med Chem Lett. 2010 Sep 1;20(17):5126-9. DM3S2P8 RU https://pubmed.ncbi.nlm.nih.gov/20688518 DMABMPQ DI DMABMPQ DMABMPQ DN 4-methylhistamine DMABMPQ MI TTXJ178 DMABMPQ MN Histamine H4 receptor (H4R) DMABMPQ MT DTT DMABMPQ MA Agonist DMABMPQ RN Compared pharmacology of human histamine H3 and H4 receptors: structure-activity relationships of histamine derivatives. Br J Pharmacol. 2006 Apr;147(7):744-54. DMABMPQ RU https://pubmed.ncbi.nlm.nih.gov/16432504 DM45N6U DI DM45N6U DM45N6U DN 4-Methylimidazole DM45N6U MI TTANPDJ DM45N6U MN Carbonic anhydrase II (CA-II) DM45N6U MT DTT DM45N6U MA Inhibitor DM45N6U RN DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Nucleic Acids Res. 2011 Jan;39(Database issue):D1035-41. DM45N6U RU https://pubmed.ncbi.nlm.nih.gov/21059682 DMSF5DR DI DMSF5DR DMSF5DR DN 4-Methyl-N-(4-phenyl-thiazol-2-yl)-benzamide DMSF5DR MI TTK25J1 DMSF5DR MN Adenosine A1 receptor (ADORA1) DMSF5DR MT DTT DMSF5DR MA Inhibitor DMSF5DR RN Substituted 4-phenyl-2-(phenylcarboxamido)-1,3-thiazole derivatives as antagonists for the adenosine A(1) receptor. Bioorg Med Chem Lett. 2001 Aug 6;11(15):2017-9. DMSF5DR RU https://pubmed.ncbi.nlm.nih.gov/11454470 DMFRASQ DI DMFRASQ DMFRASQ DN 4-methyl-N-(naphthalen-1-yl)thiazol-2-amine DMFRASQ MI TT7HQD0 DMFRASQ MN C-C chemokine receptor type 4 (CCR4) DMFRASQ MT DTT DMFRASQ MA Inhibitor DMFRASQ RN Optimization of 2-aminothiazole derivatives as CCR4 antagonists. Bioorg Med Chem Lett. 2006 May 15;16(10):2800-3. DMFRASQ RU https://pubmed.ncbi.nlm.nih.gov/16497499 DMN45EH DI DMN45EH DMN45EH DN 4-methyl-N-propyl-3,4-dihydroquinazolin-2-amine DMN45EH MI TTRUFDT DMN45EH MN 5-HT 5A receptor (HTR5A) DMN45EH MT DTT DMN45EH MA Inhibitor DMN45EH RN Cyclic guanidines as dual 5-HT5A/5-HT7 receptor ligands: optimising brain penetration. Bioorg Med Chem Lett. 2008 Jan 1;18(1):262-6. DMN45EH RU https://pubmed.ncbi.nlm.nih.gov/18023344 DME7W0Q DI DME7W0Q DME7W0Q DN 4-Methyl-oxazolidin-(2Z)-ylideneamine DME7W0Q MI TTZUFI5 DME7W0Q MN Nitric-oxide synthase brain (NOS1) DME7W0Q MT DTT DME7W0Q MA Inhibitor DME7W0Q RN 4,5-Disubstituted-1,3-oxazolidin-2-imine derivatives: a new class of orally bioavailable nitric oxide synthase inhibitor. Bioorg Med Chem Lett. 2004 Jan 19;14(2):313-6. DME7W0Q RU https://pubmed.ncbi.nlm.nih.gov/14698148 DME7W0Q DI DME7W0Q DME7W0Q DN 4-Methyl-oxazolidin-(2Z)-ylideneamine DME7W0Q MI TTF10I9 DME7W0Q MN Nitric-oxide synthase inducible (NOS2) DME7W0Q MT DTT DME7W0Q MA Inhibitor DME7W0Q RN 4,5-Disubstituted-1,3-oxazolidin-2-imine derivatives: a new class of orally bioavailable nitric oxide synthase inhibitor. Bioorg Med Chem Lett. 2004 Jan 19;14(2):313-6. DME7W0Q RU https://pubmed.ncbi.nlm.nih.gov/14698148 DMR5NLM DI DMR5NLM DMR5NLM DN 4-methylphenyl-difluoromethanesulfonamide DMR5NLM MI TTUNARX DMR5NLM MN Carbonic anhydrase (CA) DMR5NLM MT DTT DMR5NLM MA Inhibitor DMR5NLM RN Carbonic anhydrase inhibitors: inhibition of the human isozymes I, II, VA, and IX with a library of substituted difluoromethanesulfonamides. Bioorg Med Chem Lett. 2005 Dec 1;15(23):5192-6. DMR5NLM RU https://pubmed.ncbi.nlm.nih.gov/16203142 DMR5NLM DI DMR5NLM DMR5NLM DN 4-methylphenyl-difluoromethanesulfonamide DMR5NLM MI TTHQPL7 DMR5NLM MN Carbonic anhydrase I (CA-I) DMR5NLM MT DTT DMR5NLM MA Inhibitor DMR5NLM RN Carbonic anhydrase inhibitors: inhibition of the human isozymes I, II, VA, and IX with a library of substituted difluoromethanesulfonamides. Bioorg Med Chem Lett. 2005 Dec 1;15(23):5192-6. DMR5NLM RU https://pubmed.ncbi.nlm.nih.gov/16203142 DMR5NLM DI DMR5NLM DMR5NLM DN 4-methylphenyl-difluoromethanesulfonamide DMR5NLM MI TTANPDJ DMR5NLM MN Carbonic anhydrase II (CA-II) DMR5NLM MT DTT DMR5NLM MA Inhibitor DMR5NLM RN Carbonic anhydrase inhibitors: inhibition of the human isozymes I, II, VA, and IX with a library of substituted difluoromethanesulfonamides. Bioorg Med Chem Lett. 2005 Dec 1;15(23):5192-6. DMR5NLM RU https://pubmed.ncbi.nlm.nih.gov/16203142 DMR5NLM DI DMR5NLM DMR5NLM DN 4-methylphenyl-difluoromethanesulfonamide DMR5NLM MI TT2LVK8 DMR5NLM MN Carbonic anhydrase IX (CA-IX) DMR5NLM MT DTT DMR5NLM MA Inhibitor DMR5NLM RN Carbonic anhydrase inhibitors: inhibition of the human isozymes I, II, VA, and IX with a library of substituted difluoromethanesulfonamides. Bioorg Med Chem Lett. 2005 Dec 1;15(23):5192-6. DMR5NLM RU https://pubmed.ncbi.nlm.nih.gov/16203142 DMNMXCE DI DMNMXCE DMNMXCE DN 4-Methyl-piperidin-(2E)-ylideneamine DMNMXCE MI TTZUFI5 DMNMXCE MN Nitric-oxide synthase brain (NOS1) DMNMXCE MT DTT DMNMXCE MA Inhibitor DMNMXCE RN Bicyclic amidine inhibitors of nitric oxide synthase: discovery of perhydro-iminopyrindine and perhydro-iminoquinoline as potent, orally active inh... Bioorg Med Chem Lett. 2005 Apr 15;15(8):1997-2001. DMNMXCE RU https://pubmed.ncbi.nlm.nih.gov/15808455 DMNMXCE DI DMNMXCE DMNMXCE DN 4-Methyl-piperidin-(2E)-ylideneamine DMNMXCE MI TTCM4B3 DMNMXCE MN Nitric-oxide synthase endothelial (NOS3) DMNMXCE MT DTT DMNMXCE MA Inhibitor DMNMXCE RN Bicyclic amidine inhibitors of nitric oxide synthase: discovery of perhydro-iminopyrindine and perhydro-iminoquinoline as potent, orally active inh... Bioorg Med Chem Lett. 2005 Apr 15;15(8):1997-2001. DMNMXCE RU https://pubmed.ncbi.nlm.nih.gov/15808455 DMNMXCE DI DMNMXCE DMNMXCE DN 4-Methyl-piperidin-(2E)-ylideneamine DMNMXCE MI TTF10I9 DMNMXCE MN Nitric-oxide synthase inducible (NOS2) DMNMXCE MT DTT DMNMXCE MA Inhibitor DMNMXCE RN Bicyclic amidine inhibitors of nitric oxide synthase: discovery of perhydro-iminopyrindine and perhydro-iminoquinoline as potent, orally active inh... Bioorg Med Chem Lett. 2005 Apr 15;15(8):1997-2001. DMNMXCE RU https://pubmed.ncbi.nlm.nih.gov/15808455 DME6UOM DI DME6UOM DME6UOM DN 4-Methyl-pyridine DME6UOM MI TTKNWZ4 DME6UOM MN Thromboxane-A synthase (TBXAS1) DME6UOM MT DTT DME6UOM MA Inhibitor DME6UOM RN Highly selective inhibitors of thromboxane synthetase. 2. Pyridine derivatives. J Med Chem. 1981 Oct;24(10):1149-55. DME6UOM RU https://pubmed.ncbi.nlm.nih.gov/7199089 DM0YS36 DI DM0YS36 DM0YS36 DN 4-Methyl-pyrrolidin-(2Z)-ylideneamine DM0YS36 MI TTZUFI5 DM0YS36 MN Nitric-oxide synthase brain (NOS1) DM0YS36 MT DTT DM0YS36 MA Inhibitor DM0YS36 RN Evaluation of pyrrolidin-2-imines and 1,3-thiazolidin-2-imines as inhibitors of nitric oxide synthase. Bioorg Med Chem Lett. 2004 Sep 6;14(17):4539-44. DM0YS36 RU https://pubmed.ncbi.nlm.nih.gov/15357988 DM0YS36 DI DM0YS36 DM0YS36 DN 4-Methyl-pyrrolidin-(2Z)-ylideneamine DM0YS36 MI TTCM4B3 DM0YS36 MN Nitric-oxide synthase endothelial (NOS3) DM0YS36 MT DTT DM0YS36 MA Inhibitor DM0YS36 RN Evaluation of pyrrolidin-2-imines and 1,3-thiazolidin-2-imines as inhibitors of nitric oxide synthase. Bioorg Med Chem Lett. 2004 Sep 6;14(17):4539-44. DM0YS36 RU https://pubmed.ncbi.nlm.nih.gov/15357988 DM0YS36 DI DM0YS36 DM0YS36 DN 4-Methyl-pyrrolidin-(2Z)-ylideneamine DM0YS36 MI TTF10I9 DM0YS36 MN Nitric-oxide synthase inducible (NOS2) DM0YS36 MT DTT DM0YS36 MA Inhibitor DM0YS36 RN Evaluation of pyrrolidin-2-imines and 1,3-thiazolidin-2-imines as inhibitors of nitric oxide synthase. Bioorg Med Chem Lett. 2004 Sep 6;14(17):4539-44. DM0YS36 RU https://pubmed.ncbi.nlm.nih.gov/15357988 DMVMHBL DI DMVMHBL DMVMHBL DN 4-methylpyrrolo[3,4-c]carbazole-1,3(2H,6H)-dione DMVMHBL MI TTVDSZ0 DMVMHBL MN Poly [ADP-ribose] polymerase 1 (PARP1) DMVMHBL MT DTT DMVMHBL MA Inhibitor DMVMHBL RN Synthesis and structure-activity relationships of novel poly(ADP-ribose) polymerase-1 inhibitors. Bioorg Med Chem Lett. 2006 Feb 15;16(4):938-42. DMVMHBL RU https://pubmed.ncbi.nlm.nih.gov/16290935 DMW0Y29 DI DMW0Y29 DMW0Y29 DN 4-methylstyrylboronic acid DMW0Y29 MI TTHQPL7 DMW0Y29 MN Carbonic anhydrase I (CA-I) DMW0Y29 MT DTT DMW0Y29 MA Inhibitor DMW0Y29 RN Carbonic anhydrase inhibitors. Inhibition of the fungal beta-carbonic anhydrases from Candida albicans and Cryptococcus neoformans with boronic acids. Bioorg Med Chem Lett. 2009 May 15;19(10):2642-5. DMW0Y29 RU https://pubmed.ncbi.nlm.nih.gov/19375309 DMEB5XP DI DMEB5XP DMEB5XP DN 4-Methylthiopyridine-3-sulfonamide DMEB5XP MI TTHQPL7 DMEB5XP MN Carbonic anhydrase I (CA-I) DMEB5XP MT DTT DMEB5XP MA Inhibitor DMEB5XP RN Carbonic anhydrase inhibitors: synthesis and inhibition of the human cytosolic isozymes I and II and transmembrane isozymes IX, XII (cancer-associa... Eur J Med Chem. 2010 Jun;45(6):2396-404. DMEB5XP RU https://pubmed.ncbi.nlm.nih.gov/20202722 DMEB5XP DI DMEB5XP DMEB5XP DN 4-Methylthiopyridine-3-sulfonamide DMEB5XP MI TTANPDJ DMEB5XP MN Carbonic anhydrase II (CA-II) DMEB5XP MT DTT DMEB5XP MA Inhibitor DMEB5XP RN Carbonic anhydrase inhibitors: synthesis and inhibition of the human cytosolic isozymes I and II and transmembrane isozymes IX, XII (cancer-associa... Eur J Med Chem. 2010 Jun;45(6):2396-404. DMEB5XP RU https://pubmed.ncbi.nlm.nih.gov/20202722 DMEB5XP DI DMEB5XP DMEB5XP DN 4-Methylthiopyridine-3-sulfonamide DMEB5XP MI TT2LVK8 DMEB5XP MN Carbonic anhydrase IX (CA-IX) DMEB5XP MT DTT DMEB5XP MA Inhibitor DMEB5XP RN Carbonic anhydrase inhibitors: synthesis and inhibition of the human cytosolic isozymes I and II and transmembrane isozymes IX, XII (cancer-associa... Eur J Med Chem. 2010 Jun;45(6):2396-404. DMEB5XP RU https://pubmed.ncbi.nlm.nih.gov/20202722 DMEB5XP DI DMEB5XP DMEB5XP DN 4-Methylthiopyridine-3-sulfonamide DMEB5XP MI TTSYM0R DMEB5XP MN Carbonic anhydrase XII (CA-XII) DMEB5XP MT DTT DMEB5XP MA Inhibitor DMEB5XP RN Carbonic anhydrase inhibitors: synthesis and inhibition of the human cytosolic isozymes I and II and transmembrane isozymes IX, XII (cancer-associa... Eur J Med Chem. 2010 Jun;45(6):2396-404. DMEB5XP RU https://pubmed.ncbi.nlm.nih.gov/20202722 DMEB5XP DI DMEB5XP DMEB5XP DN 4-Methylthiopyridine-3-sulfonamide DMEB5XP MI TTEYTKG DMEB5XP MN Carbonic anhydrase XIV (CA-XIV) DMEB5XP MT DTT DMEB5XP MA Inhibitor DMEB5XP RN Carbonic anhydrase inhibitors: synthesis and inhibition of the human cytosolic isozymes I and II and transmembrane isozymes IX, XII (cancer-associa... Eur J Med Chem. 2010 Jun;45(6):2396-404. DMEB5XP RU https://pubmed.ncbi.nlm.nih.gov/20202722 DM049QO DI DM049QO DM049QO DN 4-Morpholin-2-yl-benzene-1,2-diol DM049QO MI TTNGILX DM049QO MN Adrenergic receptor alpha-1A (ADRA1A) DM049QO MT DTT DM049QO MA Inhibitor DM049QO RN Conformational effects on the activity of drugs. 13. A revision of previously proposed models for the activation of alpha- and beta-adrenergic rece... J Med Chem. 1992 Mar 20;35(6):1009-18. DM049QO RU https://pubmed.ncbi.nlm.nih.gov/1313109 DM049QO DI DM049QO DM049QO DN 4-Morpholin-2-yl-benzene-1,2-diol DM049QO MI TTBRKXS DM049QO MN Adrenergic receptor alpha-1B (ADRA1B) DM049QO MT DTT DM049QO MA Inhibitor DM049QO RN Conformational effects on the activity of drugs. 13. A revision of previously proposed models for the activation of alpha- and beta-adrenergic rece... J Med Chem. 1992 Mar 20;35(6):1009-18. DM049QO RU https://pubmed.ncbi.nlm.nih.gov/1313109 DM049QO DI DM049QO DM049QO DN 4-Morpholin-2-yl-benzene-1,2-diol DM049QO MI TT34BHT DM049QO MN Adrenergic receptor alpha-1D (ADRA1D) DM049QO MT DTT DM049QO MA Inhibitor DM049QO RN Conformational effects on the activity of drugs. 13. A revision of previously proposed models for the activation of alpha- and beta-adrenergic rece... J Med Chem. 1992 Mar 20;35(6):1009-18. DM049QO RU https://pubmed.ncbi.nlm.nih.gov/1313109 DMEJ6G9 DI DMEJ6G9 DMEJ6G9 DN 4-Morpholin-4-yl-benzo[g]chromen-2-one DMEJ6G9 MI TTK3PY9 DMEJ6G9 MN DNA-dependent protein kinase catalytic (PRKDC) DMEJ6G9 MT DTT DMEJ6G9 MA Inhibitor DMEJ6G9 RN Selective benzopyranone and pyrimido[2,1-a]isoquinolin-4-one inhibitors of DNA-dependent protein kinase: synthesis, structure-activity studies, and... J Med Chem. 2005 Jan 27;48(2):569-85. DMEJ6G9 RU https://pubmed.ncbi.nlm.nih.gov/15658870 DMW2MRP DI DMW2MRP DMW2MRP DN 4-Morpholin-4-yl-benzo[h]chromen-2-one DMW2MRP MI TTK3PY9 DMW2MRP MN DNA-dependent protein kinase catalytic (PRKDC) DMW2MRP MT DTT DMW2MRP MA Inhibitor DMW2MRP RN Selective benzopyranone and pyrimido[2,1-a]isoquinolin-4-one inhibitors of DNA-dependent protein kinase: synthesis, structure-activity studies, and... J Med Chem. 2005 Jan 27;48(2):569-85. DMW2MRP RU https://pubmed.ncbi.nlm.nih.gov/15658870 DM7T3CU DI DM7T3CU DM7T3CU DN 4-Morpholin-4-yl-chromen-2-one DM7T3CU MI TTK3PY9 DM7T3CU MN DNA-dependent protein kinase catalytic (PRKDC) DM7T3CU MT DTT DM7T3CU MA Inhibitor DM7T3CU RN Selective benzopyranone and pyrimido[2,1-a]isoquinolin-4-one inhibitors of DNA-dependent protein kinase: synthesis, structure-activity studies, and... J Med Chem. 2005 Jan 27;48(2):569-85. DM7T3CU RU https://pubmed.ncbi.nlm.nih.gov/15658870 DM8QPTJ DI DM8QPTJ DM8QPTJ DN 4-morpholino-6-phenyl-2H-pyran-2-one DM8QPTJ MI TTK3PY9 DM8QPTJ MN DNA-dependent protein kinase catalytic (PRKDC) DM8QPTJ MT DTT DM8QPTJ MA Inhibitor DM8QPTJ RN Pyranone, thiopyranone, and pyridone inhibitors of phosphatidylinositol 3-kinase related kinases. Structure-activity relationships for DNA-dependen... J Med Chem. 2007 Apr 19;50(8):1958-72. DM8QPTJ RU https://pubmed.ncbi.nlm.nih.gov/17371003 DM4E6HW DI DM4E6HW DM4E6HW DN 4-MPPTS DM4E6HW MI TTXJ47W DM4E6HW MN Metabotropic glutamate receptor 2 (mGluR2) DM4E6HW MT DTT DM4E6HW MA Modulator (allosteric modulator) DM4E6HW RN SAR study of a subtype selective allosteric potentiator of metabotropic glutamate 2 receptor, N-(4-phenoxyphenyl)-N-(3-pyridinylmethyl)ethanesulfonamide. Bioorg Med Chem Lett. 2004 Jun 21;14(12):3099-102. DM4E6HW RU https://pubmed.ncbi.nlm.nih.gov/15149652 DMEIA3L DI DMEIA3L DMEIA3L DN 4-Naphthalen-1-yl-5-piperidin-4-yl-isoxazol-3-ol DMEIA3L MI TT1MPAY DMEIA3L MN GABA(A) receptor alpha-1 (GABRA1) DMEIA3L MT DTT DMEIA3L MA Inhibitor DMEIA3L RN Potent 4-aryl- or 4-arylalkyl-substituted 3-isoxazolol GABA(A) antagonists: synthesis, pharmacology, and molecular modeling. J Med Chem. 2005 Jan 27;48(2):427-39. DMEIA3L RU https://pubmed.ncbi.nlm.nih.gov/15658856 DMEIA3L DI DMEIA3L DMEIA3L DN 4-Naphthalen-1-yl-5-piperidin-4-yl-isoxazol-3-ol DMEIA3L MI TTZA1NY DMEIA3L MN GABA(A) receptor beta-2 (GABRB2) DMEIA3L MT DTT DMEIA3L MA Inhibitor DMEIA3L RN Potent 4-aryl- or 4-arylalkyl-substituted 3-isoxazolol GABA(A) antagonists: synthesis, pharmacology, and molecular modeling. J Med Chem. 2005 Jan 27;48(2):427-39. DMEIA3L RU https://pubmed.ncbi.nlm.nih.gov/15658856 DMEIA3L DI DMEIA3L DMEIA3L DN 4-Naphthalen-1-yl-5-piperidin-4-yl-isoxazol-3-ol DMEIA3L MI TT06RH5 DMEIA3L MN GABA(A) receptor gamma-2 (GABRG2) DMEIA3L MT DTT DMEIA3L MA Inhibitor DMEIA3L RN Potent 4-aryl- or 4-arylalkyl-substituted 3-isoxazolol GABA(A) antagonists: synthesis, pharmacology, and molecular modeling. J Med Chem. 2005 Jan 27;48(2):427-39. DMEIA3L RU https://pubmed.ncbi.nlm.nih.gov/15658856 DMEIA3L DI DMEIA3L DMEIA3L DN 4-Naphthalen-1-yl-5-piperidin-4-yl-isoxazol-3-ol DMEIA3L MI TTNJYV2 DMEIA3L MN Gamma-aminobutyric acid receptor (GAR) DMEIA3L MT DTT DMEIA3L MA Inhibitor DMEIA3L RN Potent 4-aryl- or 4-arylalkyl-substituted 3-isoxazolol GABA(A) antagonists: synthesis, pharmacology, and molecular modeling. J Med Chem. 2005 Jan 27;48(2):427-39. DMEIA3L RU https://pubmed.ncbi.nlm.nih.gov/15658856 DM9O8UM DI DM9O8UM DM9O8UM DN 4-Naphthalen-2-yl-5-piperidin-4-yl-isoxazol-3-ol DM9O8UM MI TT1MPAY DM9O8UM MN GABA(A) receptor alpha-1 (GABRA1) DM9O8UM MT DTT DM9O8UM MA Inhibitor DM9O8UM RN Potent 4-aryl- or 4-arylalkyl-substituted 3-isoxazolol GABA(A) antagonists: synthesis, pharmacology, and molecular modeling. J Med Chem. 2005 Jan 27;48(2):427-39. DM9O8UM RU https://pubmed.ncbi.nlm.nih.gov/15658856 DM9O8UM DI DM9O8UM DM9O8UM DN 4-Naphthalen-2-yl-5-piperidin-4-yl-isoxazol-3-ol DM9O8UM MI TTZA1NY DM9O8UM MN GABA(A) receptor beta-2 (GABRB2) DM9O8UM MT DTT DM9O8UM MA Inhibitor DM9O8UM RN Potent 4-aryl- or 4-arylalkyl-substituted 3-isoxazolol GABA(A) antagonists: synthesis, pharmacology, and molecular modeling. J Med Chem. 2005 Jan 27;48(2):427-39. DM9O8UM RU https://pubmed.ncbi.nlm.nih.gov/15658856 DM9O8UM DI DM9O8UM DM9O8UM DN 4-Naphthalen-2-yl-5-piperidin-4-yl-isoxazol-3-ol DM9O8UM MI TT06RH5 DM9O8UM MN GABA(A) receptor gamma-2 (GABRG2) DM9O8UM MT DTT DM9O8UM MA Inhibitor DM9O8UM RN Potent 4-aryl- or 4-arylalkyl-substituted 3-isoxazolol GABA(A) antagonists: synthesis, pharmacology, and molecular modeling. J Med Chem. 2005 Jan 27;48(2):427-39. DM9O8UM RU https://pubmed.ncbi.nlm.nih.gov/15658856 DM9O8UM DI DM9O8UM DM9O8UM DN 4-Naphthalen-2-yl-5-piperidin-4-yl-isoxazol-3-ol DM9O8UM MI TTNJYV2 DM9O8UM MN Gamma-aminobutyric acid receptor (GAR) DM9O8UM MT DTT DM9O8UM MA Inhibitor DM9O8UM RN Potent 4-aryl- or 4-arylalkyl-substituted 3-isoxazolol GABA(A) antagonists: synthesis, pharmacology, and molecular modeling. J Med Chem. 2005 Jan 27;48(2):427-39. DM9O8UM RU https://pubmed.ncbi.nlm.nih.gov/15658856 DMKPNSH DI DMKPNSH DMKPNSH DN 4-Naphthalen-2-yl-phenol DMKPNSH MI TTZAYWL DMKPNSH MN Estrogen receptor (ESR) DMKPNSH MT DTT DMKPNSH MA Inhibitor DMKPNSH RN ERbeta ligands. 3. Exploiting two binding orientations of the 2-phenylnaphthalene scaffold to achieve ERbeta selectivity. J Med Chem. 2005 Jun 16;48(12):3953-79. DMKPNSH RU https://pubmed.ncbi.nlm.nih.gov/15943471 DMKPNSH DI DMKPNSH DMKPNSH DN 4-Naphthalen-2-yl-phenol DMKPNSH MI TTOM3J0 DMKPNSH MN Estrogen receptor beta (ESR2) DMKPNSH MT DTT DMKPNSH MA Inhibitor DMKPNSH RN ERbeta ligands. 3. Exploiting two binding orientations of the 2-phenylnaphthalene scaffold to achieve ERbeta selectivity. J Med Chem. 2005 Jun 16;48(12):3953-79. DMKPNSH RU https://pubmed.ncbi.nlm.nih.gov/15943471 DMZY8UW DI DMZY8UW DMZY8UW DN 4-Nitro-benzenesulfonamide DMZY8UW MI TTUNARX DMZY8UW MN Carbonic anhydrase (CA) DMZY8UW MT DTT DMZY8UW MA Inhibitor DMZY8UW RN Carbonic anhydrase inhibitors: inhibition of human cytosolic isozyme II and mitochondrial isozyme V with a series of benzene sulfonamide derivatives. Bioorg Med Chem Lett. 2004 Nov 15;14(22):5703-7. DMZY8UW RU https://pubmed.ncbi.nlm.nih.gov/15482952 DMZY8UW DI DMZY8UW DMZY8UW DN 4-Nitro-benzenesulfonamide DMZY8UW MI TTANPDJ DMZY8UW MN Carbonic anhydrase II (CA-II) DMZY8UW MT DTT DMZY8UW MA Inhibitor DMZY8UW RN Carbonic anhydrase inhibitors: inhibition of human cytosolic isozyme II and mitochondrial isozyme V with a series of benzene sulfonamide derivatives. Bioorg Med Chem Lett. 2004 Nov 15;14(22):5703-7. DMZY8UW RU https://pubmed.ncbi.nlm.nih.gov/15482952 DMKZJ1V DI DMKZJ1V DMKZJ1V DN 4-nitrobenzo[c][1,2,5]thiadiazole DMKZJ1V MI TTEP6RV DMKZJ1V MN Glutathione reductase (GR) DMKZJ1V MT DTT DMKZJ1V MA Inhibitor DMKZJ1V RN Specific inhibitors of Plasmodium falciparum thioredoxin reductase as potential antimalarial agents. Bioorg Med Chem Lett. 2006 Apr 15;16(8):2283-92. DMKZJ1V RU https://pubmed.ncbi.nlm.nih.gov/16458512 DMKZUWY DI DMKZUWY DMKZUWY DN 4-Nitro-N-(4-phenyl-thiazol-2-yl)-benzamide DMKZUWY MI TTK25J1 DMKZUWY MN Adenosine A1 receptor (ADORA1) DMKZUWY MT DTT DMKZUWY MA Inhibitor DMKZUWY RN Substituted 4-phenyl-2-(phenylcarboxamido)-1,3-thiazole derivatives as antagonists for the adenosine A(1) receptor. Bioorg Med Chem Lett. 2001 Aug 6;11(15):2017-9. DMKZUWY RU https://pubmed.ncbi.nlm.nih.gov/11454470 DMLJDU5 DI DMLJDU5 DMLJDU5 DN 4-nitro-N-(quinolin-8-yl)benzenesulfonamide DMLJDU5 MI TTSXVID DMLJDU5 MN Nuclear factor NF-kappa-B (NFKB) DMLJDU5 MT DTT DMLJDU5 MA Inhibitor DMLJDU5 RN Identification of N-(quinolin-8-yl)benzenesulfonamides as agents capable of down-regulating NFkappaB activity within two separate high-throughput s... Bioorg Med Chem Lett. 2008 Jan 1;18(1):329-35. DMLJDU5 RU https://pubmed.ncbi.nlm.nih.gov/18024113 DMTJ3F9 DI DMTJ3F9 DMTJ3F9 DN 4-Nitrophenyl 4-Benzylpiperazine-1-carboxylate DMTJ3F9 MI TTDP1UC DMTJ3F9 MN Fatty acid amide hydrolase (FAAH) DMTJ3F9 MT DTT DMTJ3F9 MA Inhibitor DMTJ3F9 RN Characterization of tunable piperidine and piperazine carbamates as inhibitors of endocannabinoid hydrolases. J Med Chem. 2010 Feb 25;53(4):1830-42. DMTJ3F9 RU https://pubmed.ncbi.nlm.nih.gov/20099888 DMBX4UJ DI DMBX4UJ DMBX4UJ DN 4-nitrophenyl phosphate DMBX4UJ MI TTUNARX DMBX4UJ MN Carbonic anhydrase (CA) DMBX4UJ MT DTT DMBX4UJ MA Inhibitor DMBX4UJ RN Paraoxon, 4-nitrophenyl phosphate and acetate are substrates of - but not of -, - and -carbonic anhydrases. Bioorg Med Chem Lett. 2010 Nov 1;20(21):6208-12. DMBX4UJ RU https://pubmed.ncbi.nlm.nih.gov/20833546 DMBX4UJ DI DMBX4UJ DMBX4UJ DN 4-nitrophenyl phosphate DMBX4UJ MI TTHQPL7 DMBX4UJ MN Carbonic anhydrase I (CA-I) DMBX4UJ MT DTT DMBX4UJ MA Inhibitor DMBX4UJ RN Paraoxon, 4-nitrophenyl phosphate and acetate are substrates of - but not of -, - and -carbonic anhydrases. Bioorg Med Chem Lett. 2010 Nov 1;20(21):6208-12. DMBX4UJ RU https://pubmed.ncbi.nlm.nih.gov/20833546 DMBX4UJ DI DMBX4UJ DMBX4UJ DN 4-nitrophenyl phosphate DMBX4UJ MI TTANPDJ DMBX4UJ MN Carbonic anhydrase II (CA-II) DMBX4UJ MT DTT DMBX4UJ MA Inhibitor DMBX4UJ RN Paraoxon, 4-nitrophenyl phosphate and acetate are substrates of - but not of -, - and -carbonic anhydrases. Bioorg Med Chem Lett. 2010 Nov 1;20(21):6208-12. DMBX4UJ RU https://pubmed.ncbi.nlm.nih.gov/20833546 DMBX4UJ DI DMBX4UJ DMBX4UJ DN 4-nitrophenyl phosphate DMBX4UJ MI DE6TFXV DMBX4UJ MN Tyrosine-protein phosphatase non-receptor 1 (PTP1B) DMBX4UJ MT DME DMBX4UJ MA Metabolism DMBX4UJ RN Residues distant from the active site influence protein-tyrosine phosphatase 1B inhibitor binding. J Biol Chem. 2006 Feb 24;281(8):5258-66. DMBX4UJ RU https://www.ncbi.nlm.nih.gov/pubmed/?term=16332678 DMO6XK2 DI DMO6XK2 DMO6XK2 DN 4-nitrophenylboronic acid DMO6XK2 MI TTDP1UC DMO6XK2 MN Fatty acid amide hydrolase (FAAH) DMO6XK2 MT DTT DMO6XK2 MA Inhibitor DMO6XK2 RN Discovery of boronic acids as novel and potent inhibitors of fatty acid amide hydrolase. J Med Chem. 2008 Nov 27;51(22):7057-60. DMO6XK2 RU https://pubmed.ncbi.nlm.nih.gov/18983140 DM9ETMD DI DM9ETMD DM9ETMD DN 4-nitrophenyl-difluoromethanesulfonamide DM9ETMD MI TTUNARX DM9ETMD MN Carbonic anhydrase (CA) DM9ETMD MT DTT DM9ETMD MA Inhibitor DM9ETMD RN Carbonic anhydrase inhibitors: inhibition of the human isozymes I, II, VA, and IX with a library of substituted difluoromethanesulfonamides. Bioorg Med Chem Lett. 2005 Dec 1;15(23):5192-6. DM9ETMD RU https://pubmed.ncbi.nlm.nih.gov/16203142 DM9ETMD DI DM9ETMD DM9ETMD DN 4-nitrophenyl-difluoromethanesulfonamide DM9ETMD MI TTHQPL7 DM9ETMD MN Carbonic anhydrase I (CA-I) DM9ETMD MT DTT DM9ETMD MA Inhibitor DM9ETMD RN Carbonic anhydrase inhibitors: inhibition of the human isozymes I, II, VA, and IX with a library of substituted difluoromethanesulfonamides. Bioorg Med Chem Lett. 2005 Dec 1;15(23):5192-6. DM9ETMD RU https://pubmed.ncbi.nlm.nih.gov/16203142 DM9ETMD DI DM9ETMD DM9ETMD DN 4-nitrophenyl-difluoromethanesulfonamide DM9ETMD MI TTANPDJ DM9ETMD MN Carbonic anhydrase II (CA-II) DM9ETMD MT DTT DM9ETMD MA Inhibitor DM9ETMD RN Carbonic anhydrase inhibitors: inhibition of the human isozymes I, II, VA, and IX with a library of substituted difluoromethanesulfonamides. Bioorg Med Chem Lett. 2005 Dec 1;15(23):5192-6. DM9ETMD RU https://pubmed.ncbi.nlm.nih.gov/16203142 DM9ETMD DI DM9ETMD DM9ETMD DN 4-nitrophenyl-difluoromethanesulfonamide DM9ETMD MI TT2LVK8 DM9ETMD MN Carbonic anhydrase IX (CA-IX) DM9ETMD MT DTT DM9ETMD MA Inhibitor DM9ETMD RN Carbonic anhydrase inhibitors: inhibition of the human isozymes I, II, VA, and IX with a library of substituted difluoromethanesulfonamides. Bioorg Med Chem Lett. 2005 Dec 1;15(23):5192-6. DM9ETMD RU https://pubmed.ncbi.nlm.nih.gov/16203142 DM47IFL DI DM47IFL DM47IFL DN 4-nitrophenylsulfamide DM47IFL MI TTANPDJ DM47IFL MN Carbonic anhydrase II (CA-II) DM47IFL MT DTT DM47IFL MA Inhibitor DM47IFL RN Inhibition of carbonic anhydrase-II by sulfamate and sulfamide groups: an investigation involving direct thermodynamic binding measurements. J Med Chem. 2006 Jun 15;49(12):3496-500. DM47IFL RU https://pubmed.ncbi.nlm.nih.gov/16759092 DMOW8TM DI DMOW8TM DMOW8TM DN 4-nonyl-N-(quinolin-3-yl)benzamide DMOW8TM MI TTMI6F5 DMOW8TM MN Transient receptor potential cation channel V1 (TRPV1) DMOW8TM MT DTT DMOW8TM MA Inhibitor DMOW8TM RN N-pyridin-3-yl- and N-quinolin-3-yl-benzamides: modulators of human vanilloid receptor 1 (TRPV1). Bioorg Med Chem Lett. 2008 Apr 15;18(8):2730-4. DMOW8TM RU https://pubmed.ncbi.nlm.nih.gov/18359227 DMBF5KW DI DMBF5KW DMBF5KW DN 4-nonylphenylboronic acid DMBF5KW MI TTDP1UC DMBF5KW MN Fatty acid amide hydrolase (FAAH) DMBF5KW MT DTT DMBF5KW MA Inhibitor DMBF5KW RN Discovery of boronic acids as novel and potent inhibitors of fatty acid amide hydrolase. J Med Chem. 2008 Nov 27;51(22):7057-60. DMBF5KW RU https://pubmed.ncbi.nlm.nih.gov/18983140 DMNSU1H DI DMNSU1H DMNSU1H DN 4-octyl-N-(pyridin-3-yl)benzamide DMNSU1H MI TTMI6F5 DMNSU1H MN Transient receptor potential cation channel V1 (TRPV1) DMNSU1H MT DTT DMNSU1H MA Inhibitor DMNSU1H RN N-pyridin-3-yl- and N-quinolin-3-yl-benzamides: modulators of human vanilloid receptor 1 (TRPV1). Bioorg Med Chem Lett. 2008 Apr 15;18(8):2730-4. DMNSU1H RU https://pubmed.ncbi.nlm.nih.gov/18359227 DMOGM3H DI DMOGM3H DMOGM3H DN 4-octyl-N-(quinolin-3-yl)benzamide DMOGM3H MI TTMI6F5 DMOGM3H MN Transient receptor potential cation channel V1 (TRPV1) DMOGM3H MT DTT DMOGM3H MA Inhibitor DMOGM3H RN N-pyridin-3-yl- and N-quinolin-3-yl-benzamides: modulators of human vanilloid receptor 1 (TRPV1). Bioorg Med Chem Lett. 2008 Apr 15;18(8):2730-4. DMOGM3H RU https://pubmed.ncbi.nlm.nih.gov/18359227 DM7GW4P DI DM7GW4P DM7GW4P DN 4-oxo-4H-chromene-3-carboxylic acid DM7GW4P MI TTGP7BY DM7GW4P MN Monoamine oxidase type B (MAO-B) DM7GW4P MT DTT DM7GW4P MA Inhibitor DM7GW4P RN Chromone-2- and -3-carboxylic acids inhibit differently monoamine oxidases A and B. Bioorg Med Chem Lett. 2010 May 1;20(9):2709-12. DM7GW4P RU https://pubmed.ncbi.nlm.nih.gov/20382016 DMPX1J9 DI DMPX1J9 DMPX1J9 DN 4-oxo-nonenal DMPX1J9 MI DEGQTXO DMPX1J9 MN Aldo-keto reductase 1C3 (AKR1C3) DMPX1J9 MT DME DMPX1J9 MA Metabolism DMPX1J9 RN Instability of C154Y variant of aldo-keto reductase 1C3. Chem Biol Interact. 2017 Oct 1;276:194-202. DMPX1J9 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=28025170 DMPX1J9 DI DMPX1J9 DMPX1J9 DN 4-oxo-nonenal DMPX1J9 MI TTELV3W DMPX1J9 MN Transformation-sensitive protein p120 (TRPA1) DMPX1J9 MT DTT DMPX1J9 MA Activator DMPX1J9 RN Transient receptor potential A1 is a sensory receptor for multiple products of oxidative stress. J Neurosci. 2008 Mar 5;28(10):2485-94. DMPX1J9 RU https://pubmed.ncbi.nlm.nih.gov/18322093 DMADSUY DI DMADSUY DMADSUY DN 4-Oxosebacic Acid DMADSUY MI TTJHKYD DMADSUY MN Delta-aminolevulinic acid dehydratase (ALAD) DMADSUY MT DTT DMADSUY MA Inhibitor DMADSUY RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMADSUY RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMN1XMK DI DMN1XMK DMN1XMK DN 4-Pentadeca-1,3,6-trienylsulfanyl-butyric acid DMN1XMK MI TT2J34L DMN1XMK MN Arachidonate 5-lipoxygenase (5-LOX) DMN1XMK MT DTT DMN1XMK MA Inhibitor DMN1XMK RN Design, synthesis, and 5-lipoxygenase-inhibiting properties of 1-thio-substituted butadienes. J Med Chem. 1990 Apr;33(4):1163-70. DMN1XMK RU https://pubmed.ncbi.nlm.nih.gov/2319562 DMW198G DI DMW198G DMW198G DN 4-pentyl-N-pyridin-3-yl benzamide DMW198G MI TTMI6F5 DMW198G MN Transient receptor potential cation channel V1 (TRPV1) DMW198G MT DTT DMW198G MA Inhibitor DMW198G RN N-pyridin-3-yl- and N-quinolin-3-yl-benzamides: modulators of human vanilloid receptor 1 (TRPV1). Bioorg Med Chem Lett. 2008 Apr 15;18(8):2730-4. DMW198G RU https://pubmed.ncbi.nlm.nih.gov/18359227 DMIPQTW DI DMIPQTW DMIPQTW DN 4-PHENOXY-N-(PYRIDIN-2-YLMETHYL)BENZAMIDE DMIPQTW MI TTQBR95 DMIPQTW MN Stress-activated protein kinase 2a (p38 alpha) DMIPQTW MT DTT DMIPQTW MA Inhibitor DMIPQTW RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DMIPQTW RU https://pubmed.ncbi.nlm.nih.gov/10592235 DMMWYI9 DI DMMWYI9 DMMWYI9 DN 4-phenoxyphenylboronic acid DMMWYI9 MI TTUNARX DMMWYI9 MN Carbonic anhydrase (CA) DMMWYI9 MT DTT DMMWYI9 MA Inhibitor DMMWYI9 RN Carbonic anhydrase inhibitors. Inhibition of the fungal beta-carbonic anhydrases from Candida albicans and Cryptococcus neoformans with boronic acids. Bioorg Med Chem Lett. 2009 May 15;19(10):2642-5. DMMWYI9 RU https://pubmed.ncbi.nlm.nih.gov/19375309 DMMWYI9 DI DMMWYI9 DMMWYI9 DN 4-phenoxyphenylboronic acid DMMWYI9 MI TTHQPL7 DMMWYI9 MN Carbonic anhydrase I (CA-I) DMMWYI9 MT DTT DMMWYI9 MA Inhibitor DMMWYI9 RN Carbonic anhydrase inhibitors. Inhibition of the fungal beta-carbonic anhydrases from Candida albicans and Cryptococcus neoformans with boronic acids. Bioorg Med Chem Lett. 2009 May 15;19(10):2642-5. DMMWYI9 RU https://pubmed.ncbi.nlm.nih.gov/19375309 DMMWYI9 DI DMMWYI9 DMMWYI9 DN 4-phenoxyphenylboronic acid DMMWYI9 MI TTANPDJ DMMWYI9 MN Carbonic anhydrase II (CA-II) DMMWYI9 MT DTT DMMWYI9 MA Inhibitor DMMWYI9 RN Carbonic anhydrase inhibitors. Inhibition of the fungal beta-carbonic anhydrases from Candida albicans and Cryptococcus neoformans with boronic acids. Bioorg Med Chem Lett. 2009 May 15;19(10):2642-5. DMMWYI9 RU https://pubmed.ncbi.nlm.nih.gov/19375309 DMVCIJB DI DMVCIJB DMVCIJB DN 4-phenyl-1-(1-phenylbutyl)piperidin-4-ol DMVCIJB MI TTNT7K8 DMVCIJB MN Nociceptin receptor (OPRL1) DMVCIJB MT DTT DMVCIJB MA Inhibitor DMVCIJB RN Bioorg Med Chem Lett. 2007 Jun 1;17(11):3023-7. Epub 2007 Mar 23.Synthesis and structure-activity relationships of 4-hydroxy-4-phenylpiperidines as nociceptin receptor ligands: Part 1. DMVCIJB RU https://pubmed.ncbi.nlm.nih.gov/17428659 DMVCIJB DI DMVCIJB DMVCIJB DN 4-phenyl-1-(1-phenylbutyl)piperidin-4-ol DMVCIJB MI TT27RFC DMVCIJB MN Opioid receptor delta (OPRD1) DMVCIJB MT DTT DMVCIJB MA Inhibitor DMVCIJB RN Bioorg Med Chem Lett. 2007 Jun 1;17(11):3023-7. Epub 2007 Mar 23.Synthesis and structure-activity relationships of 4-hydroxy-4-phenylpiperidines as nociceptin receptor ligands: Part 1. DMVCIJB RU https://pubmed.ncbi.nlm.nih.gov/17428659 DMVCIJB DI DMVCIJB DMVCIJB DN 4-phenyl-1-(1-phenylbutyl)piperidin-4-ol DMVCIJB MI TTQW87Y DMVCIJB MN Opioid receptor kappa (OPRK1) DMVCIJB MT DTT DMVCIJB MA Inhibitor DMVCIJB RN Bioorg Med Chem Lett. 2007 Jun 1;17(11):3023-7. Epub 2007 Mar 23.Synthesis and structure-activity relationships of 4-hydroxy-4-phenylpiperidines as nociceptin receptor ligands: Part 1. DMVCIJB RU https://pubmed.ncbi.nlm.nih.gov/17428659 DMVCIJB DI DMVCIJB DMVCIJB DN 4-phenyl-1-(1-phenylbutyl)piperidin-4-ol DMVCIJB MI TTKWM86 DMVCIJB MN Opioid receptor mu (MOP) DMVCIJB MT DTT DMVCIJB MA Inhibitor DMVCIJB RN Bioorg Med Chem Lett. 2007 Jun 1;17(11):3023-7. Epub 2007 Mar 23.Synthesis and structure-activity relationships of 4-hydroxy-4-phenylpiperidines as nociceptin receptor ligands: Part 1. DMVCIJB RU https://pubmed.ncbi.nlm.nih.gov/17428659 DM6EFLV DI DM6EFLV DM6EFLV DN 4-phenyl-1-(1-phenylethyl)piperidin-4-ol DM6EFLV MI TTNT7K8 DM6EFLV MN Nociceptin receptor (OPRL1) DM6EFLV MT DTT DM6EFLV MA Inhibitor DM6EFLV RN Bioorg Med Chem Lett. 2007 Jun 1;17(11):3023-7. Epub 2007 Mar 23.Synthesis and structure-activity relationships of 4-hydroxy-4-phenylpiperidines as nociceptin receptor ligands: Part 1. DM6EFLV RU https://pubmed.ncbi.nlm.nih.gov/17428659 DM6EFLV DI DM6EFLV DM6EFLV DN 4-phenyl-1-(1-phenylethyl)piperidin-4-ol DM6EFLV MI TTQW87Y DM6EFLV MN Opioid receptor kappa (OPRK1) DM6EFLV MT DTT DM6EFLV MA Inhibitor DM6EFLV RN Bioorg Med Chem Lett. 2007 Jun 1;17(11):3023-7. Epub 2007 Mar 23.Synthesis and structure-activity relationships of 4-hydroxy-4-phenylpiperidines as nociceptin receptor ligands: Part 1. DM6EFLV RU https://pubmed.ncbi.nlm.nih.gov/17428659 DM6EFLV DI DM6EFLV DM6EFLV DN 4-phenyl-1-(1-phenylethyl)piperidin-4-ol DM6EFLV MI TTKWM86 DM6EFLV MN Opioid receptor mu (MOP) DM6EFLV MT DTT DM6EFLV MA Inhibitor DM6EFLV RN Bioorg Med Chem Lett. 2007 Jun 1;17(11):3023-7. Epub 2007 Mar 23.Synthesis and structure-activity relationships of 4-hydroxy-4-phenylpiperidines as nociceptin receptor ligands: Part 1. DM6EFLV RU https://pubmed.ncbi.nlm.nih.gov/17428659 DMISTXQ DI DMISTXQ DMISTXQ DN 4-phenyl-1-(1-phenylheptyl)piperidin-4-ol DMISTXQ MI TTNT7K8 DMISTXQ MN Nociceptin receptor (OPRL1) DMISTXQ MT DTT DMISTXQ MA Inhibitor DMISTXQ RN Bioorg Med Chem Lett. 2007 Jun 1;17(11):3023-7. Epub 2007 Mar 23.Synthesis and structure-activity relationships of 4-hydroxy-4-phenylpiperidines as nociceptin receptor ligands: Part 1. DMISTXQ RU https://pubmed.ncbi.nlm.nih.gov/17428659 DMISTXQ DI DMISTXQ DMISTXQ DN 4-phenyl-1-(1-phenylheptyl)piperidin-4-ol DMISTXQ MI TT27RFC DMISTXQ MN Opioid receptor delta (OPRD1) DMISTXQ MT DTT DMISTXQ MA Inhibitor DMISTXQ RN Bioorg Med Chem Lett. 2007 Jun 1;17(11):3023-7. Epub 2007 Mar 23.Synthesis and structure-activity relationships of 4-hydroxy-4-phenylpiperidines as nociceptin receptor ligands: Part 1. DMISTXQ RU https://pubmed.ncbi.nlm.nih.gov/17428659 DMISTXQ DI DMISTXQ DMISTXQ DN 4-phenyl-1-(1-phenylheptyl)piperidin-4-ol DMISTXQ MI TTQW87Y DMISTXQ MN Opioid receptor kappa (OPRK1) DMISTXQ MT DTT DMISTXQ MA Inhibitor DMISTXQ RN Bioorg Med Chem Lett. 2007 Jun 1;17(11):3023-7. Epub 2007 Mar 23.Synthesis and structure-activity relationships of 4-hydroxy-4-phenylpiperidines as nociceptin receptor ligands: Part 1. DMISTXQ RU https://pubmed.ncbi.nlm.nih.gov/17428659 DMISTXQ DI DMISTXQ DMISTXQ DN 4-phenyl-1-(1-phenylheptyl)piperidin-4-ol DMISTXQ MI TTKWM86 DMISTXQ MN Opioid receptor mu (MOP) DMISTXQ MT DTT DMISTXQ MA Inhibitor DMISTXQ RN Bioorg Med Chem Lett. 2007 Jun 1;17(11):3023-7. Epub 2007 Mar 23.Synthesis and structure-activity relationships of 4-hydroxy-4-phenylpiperidines as nociceptin receptor ligands: Part 1. DMISTXQ RU https://pubmed.ncbi.nlm.nih.gov/17428659 DM1GRWY DI DM1GRWY DM1GRWY DN 4-phenyl-1-(1-phenylhexyl)piperidin-4-ol DM1GRWY MI TTNT7K8 DM1GRWY MN Nociceptin receptor (OPRL1) DM1GRWY MT DTT DM1GRWY MA Inhibitor DM1GRWY RN Bioorg Med Chem Lett. 2007 Jun 1;17(11):3023-7. Epub 2007 Mar 23.Synthesis and structure-activity relationships of 4-hydroxy-4-phenylpiperidines as nociceptin receptor ligands: Part 1. DM1GRWY RU https://pubmed.ncbi.nlm.nih.gov/17428659 DM1GRWY DI DM1GRWY DM1GRWY DN 4-phenyl-1-(1-phenylhexyl)piperidin-4-ol DM1GRWY MI TT27RFC DM1GRWY MN Opioid receptor delta (OPRD1) DM1GRWY MT DTT DM1GRWY MA Inhibitor DM1GRWY RN Bioorg Med Chem Lett. 2007 Jun 1;17(11):3023-7. Epub 2007 Mar 23.Synthesis and structure-activity relationships of 4-hydroxy-4-phenylpiperidines as nociceptin receptor ligands: Part 1. DM1GRWY RU https://pubmed.ncbi.nlm.nih.gov/17428659 DM1GRWY DI DM1GRWY DM1GRWY DN 4-phenyl-1-(1-phenylhexyl)piperidin-4-ol DM1GRWY MI TTQW87Y DM1GRWY MN Opioid receptor kappa (OPRK1) DM1GRWY MT DTT DM1GRWY MA Inhibitor DM1GRWY RN Bioorg Med Chem Lett. 2007 Jun 1;17(11):3023-7. Epub 2007 Mar 23.Synthesis and structure-activity relationships of 4-hydroxy-4-phenylpiperidines as nociceptin receptor ligands: Part 1. DM1GRWY RU https://pubmed.ncbi.nlm.nih.gov/17428659 DM1GRWY DI DM1GRWY DM1GRWY DN 4-phenyl-1-(1-phenylhexyl)piperidin-4-ol DM1GRWY MI TTKWM86 DM1GRWY MN Opioid receptor mu (MOP) DM1GRWY MT DTT DM1GRWY MA Inhibitor DM1GRWY RN Bioorg Med Chem Lett. 2007 Jun 1;17(11):3023-7. Epub 2007 Mar 23.Synthesis and structure-activity relationships of 4-hydroxy-4-phenylpiperidines as nociceptin receptor ligands: Part 1. DM1GRWY RU https://pubmed.ncbi.nlm.nih.gov/17428659 DMZQ7DP DI DMZQ7DP DMZQ7DP DN 4-phenyl-1-(1-phenylpentyl)piperidin-4-ol DMZQ7DP MI TTNT7K8 DMZQ7DP MN Nociceptin receptor (OPRL1) DMZQ7DP MT DTT DMZQ7DP MA Inhibitor DMZQ7DP RN Bioorg Med Chem Lett. 2007 Jun 1;17(11):3023-7. Epub 2007 Mar 23.Synthesis and structure-activity relationships of 4-hydroxy-4-phenylpiperidines as nociceptin receptor ligands: Part 1. DMZQ7DP RU https://pubmed.ncbi.nlm.nih.gov/17428659 DMZQ7DP DI DMZQ7DP DMZQ7DP DN 4-phenyl-1-(1-phenylpentyl)piperidin-4-ol DMZQ7DP MI TT27RFC DMZQ7DP MN Opioid receptor delta (OPRD1) DMZQ7DP MT DTT DMZQ7DP MA Inhibitor DMZQ7DP RN Bioorg Med Chem Lett. 2007 Jun 1;17(11):3023-7. Epub 2007 Mar 23.Synthesis and structure-activity relationships of 4-hydroxy-4-phenylpiperidines as nociceptin receptor ligands: Part 1. DMZQ7DP RU https://pubmed.ncbi.nlm.nih.gov/17428659 DMZQ7DP DI DMZQ7DP DMZQ7DP DN 4-phenyl-1-(1-phenylpentyl)piperidin-4-ol DMZQ7DP MI TTQW87Y DMZQ7DP MN Opioid receptor kappa (OPRK1) DMZQ7DP MT DTT DMZQ7DP MA Inhibitor DMZQ7DP RN Bioorg Med Chem Lett. 2007 Jun 1;17(11):3023-7. Epub 2007 Mar 23.Synthesis and structure-activity relationships of 4-hydroxy-4-phenylpiperidines as nociceptin receptor ligands: Part 1. DMZQ7DP RU https://pubmed.ncbi.nlm.nih.gov/17428659 DMZQ7DP DI DMZQ7DP DMZQ7DP DN 4-phenyl-1-(1-phenylpentyl)piperidin-4-ol DMZQ7DP MI TTKWM86 DMZQ7DP MN Opioid receptor mu (MOP) DMZQ7DP MT DTT DMZQ7DP MA Inhibitor DMZQ7DP RN Bioorg Med Chem Lett. 2007 Jun 1;17(11):3023-7. Epub 2007 Mar 23.Synthesis and structure-activity relationships of 4-hydroxy-4-phenylpiperidines as nociceptin receptor ligands: Part 1. DMZQ7DP RU https://pubmed.ncbi.nlm.nih.gov/17428659 DM491FJ DI DM491FJ DM491FJ DN 4-phenyl-1-(1-phenylpropan-2-yl)piperidin-4-ol DM491FJ MI TTNT7K8 DM491FJ MN Nociceptin receptor (OPRL1) DM491FJ MT DTT DM491FJ MA Inhibitor DM491FJ RN Bioorg Med Chem Lett. 2007 Jun 1;17(11):3023-7. Epub 2007 Mar 23.Synthesis and structure-activity relationships of 4-hydroxy-4-phenylpiperidines as nociceptin receptor ligands: Part 1. DM491FJ RU https://pubmed.ncbi.nlm.nih.gov/17428659 DMALIQ8 DI DMALIQ8 DMALIQ8 DN 4-phenyl-1-(1-phenylpropyl)piperidin-4-ol DMALIQ8 MI TTNT7K8 DMALIQ8 MN Nociceptin receptor (OPRL1) DMALIQ8 MT DTT DMALIQ8 MA Inhibitor DMALIQ8 RN Bioorg Med Chem Lett. 2007 Jun 1;17(11):3023-7. Epub 2007 Mar 23.Synthesis and structure-activity relationships of 4-hydroxy-4-phenylpiperidines as nociceptin receptor ligands: Part 1. DMALIQ8 RU https://pubmed.ncbi.nlm.nih.gov/17428659 DMALIQ8 DI DMALIQ8 DMALIQ8 DN 4-phenyl-1-(1-phenylpropyl)piperidin-4-ol DMALIQ8 MI TTQW87Y DMALIQ8 MN Opioid receptor kappa (OPRK1) DMALIQ8 MT DTT DMALIQ8 MA Inhibitor DMALIQ8 RN Bioorg Med Chem Lett. 2007 Jun 1;17(11):3023-7. Epub 2007 Mar 23.Synthesis and structure-activity relationships of 4-hydroxy-4-phenylpiperidines as nociceptin receptor ligands: Part 1. DMALIQ8 RU https://pubmed.ncbi.nlm.nih.gov/17428659 DMALIQ8 DI DMALIQ8 DMALIQ8 DN 4-phenyl-1-(1-phenylpropyl)piperidin-4-ol DMALIQ8 MI TTKWM86 DMALIQ8 MN Opioid receptor mu (MOP) DMALIQ8 MT DTT DMALIQ8 MA Inhibitor DMALIQ8 RN Bioorg Med Chem Lett. 2007 Jun 1;17(11):3023-7. Epub 2007 Mar 23.Synthesis and structure-activity relationships of 4-hydroxy-4-phenylpiperidines as nociceptin receptor ligands: Part 1. DMALIQ8 RU https://pubmed.ncbi.nlm.nih.gov/17428659 DMM8O1X DI DMM8O1X DMM8O1X DN 4-phenyl-1-(3-phenylpropyl)piperidin-4-ol DMM8O1X MI TTNT7K8 DMM8O1X MN Nociceptin receptor (OPRL1) DMM8O1X MT DTT DMM8O1X MA Inhibitor DMM8O1X RN Bioorg Med Chem Lett. 2007 Jun 1;17(11):3023-7. Epub 2007 Mar 23.Synthesis and structure-activity relationships of 4-hydroxy-4-phenylpiperidines as nociceptin receptor ligands: Part 1. DMM8O1X RU https://pubmed.ncbi.nlm.nih.gov/17428659 DMFV0JC DI DMFV0JC DMFV0JC DN 4-phenyl-1-(phenyl(m-tolyl)methyl)piperidin-4-ol DMFV0JC MI TTNT7K8 DMFV0JC MN Nociceptin receptor (OPRL1) DMFV0JC MT DTT DMFV0JC MA Inhibitor DMFV0JC RN Bioorg Med Chem Lett. 2007 Jun 1;17(11):3023-7. Epub 2007 Mar 23.Synthesis and structure-activity relationships of 4-hydroxy-4-phenylpiperidines as nociceptin receptor ligands: Part 1. DMFV0JC RU https://pubmed.ncbi.nlm.nih.gov/17428659 DMFV0JC DI DMFV0JC DMFV0JC DN 4-phenyl-1-(phenyl(m-tolyl)methyl)piperidin-4-ol DMFV0JC MI TT27RFC DMFV0JC MN Opioid receptor delta (OPRD1) DMFV0JC MT DTT DMFV0JC MA Inhibitor DMFV0JC RN Bioorg Med Chem Lett. 2007 Jun 1;17(11):3023-7. Epub 2007 Mar 23.Synthesis and structure-activity relationships of 4-hydroxy-4-phenylpiperidines as nociceptin receptor ligands: Part 1. DMFV0JC RU https://pubmed.ncbi.nlm.nih.gov/17428659 DMFV0JC DI DMFV0JC DMFV0JC DN 4-phenyl-1-(phenyl(m-tolyl)methyl)piperidin-4-ol DMFV0JC MI TTQW87Y DMFV0JC MN Opioid receptor kappa (OPRK1) DMFV0JC MT DTT DMFV0JC MA Inhibitor DMFV0JC RN Bioorg Med Chem Lett. 2007 Jun 1;17(11):3023-7. Epub 2007 Mar 23.Synthesis and structure-activity relationships of 4-hydroxy-4-phenylpiperidines as nociceptin receptor ligands: Part 1. DMFV0JC RU https://pubmed.ncbi.nlm.nih.gov/17428659 DMFV0JC DI DMFV0JC DMFV0JC DN 4-phenyl-1-(phenyl(m-tolyl)methyl)piperidin-4-ol DMFV0JC MI TTKWM86 DMFV0JC MN Opioid receptor mu (MOP) DMFV0JC MT DTT DMFV0JC MA Inhibitor DMFV0JC RN Bioorg Med Chem Lett. 2007 Jun 1;17(11):3023-7. Epub 2007 Mar 23.Synthesis and structure-activity relationships of 4-hydroxy-4-phenylpiperidines as nociceptin receptor ligands: Part 1. DMFV0JC RU https://pubmed.ncbi.nlm.nih.gov/17428659 DM2MPWC DI DM2MPWC DM2MPWC DN 4-phenyl-1-(phenyl(o-tolyl)methyl)piperidin-4-ol DM2MPWC MI TTNT7K8 DM2MPWC MN Nociceptin receptor (OPRL1) DM2MPWC MT DTT DM2MPWC MA Inhibitor DM2MPWC RN Bioorg Med Chem Lett. 2007 Jun 1;17(11):3023-7. Epub 2007 Mar 23.Synthesis and structure-activity relationships of 4-hydroxy-4-phenylpiperidines as nociceptin receptor ligands: Part 1. DM2MPWC RU https://pubmed.ncbi.nlm.nih.gov/17428659 DM2MPWC DI DM2MPWC DM2MPWC DN 4-phenyl-1-(phenyl(o-tolyl)methyl)piperidin-4-ol DM2MPWC MI TT27RFC DM2MPWC MN Opioid receptor delta (OPRD1) DM2MPWC MT DTT DM2MPWC MA Inhibitor DM2MPWC RN Bioorg Med Chem Lett. 2007 Jun 1;17(11):3023-7. Epub 2007 Mar 23.Synthesis and structure-activity relationships of 4-hydroxy-4-phenylpiperidines as nociceptin receptor ligands: Part 1. DM2MPWC RU https://pubmed.ncbi.nlm.nih.gov/17428659 DM2MPWC DI DM2MPWC DM2MPWC DN 4-phenyl-1-(phenyl(o-tolyl)methyl)piperidin-4-ol DM2MPWC MI TTQW87Y DM2MPWC MN Opioid receptor kappa (OPRK1) DM2MPWC MT DTT DM2MPWC MA Inhibitor DM2MPWC RN Bioorg Med Chem Lett. 2007 Jun 1;17(11):3023-7. Epub 2007 Mar 23.Synthesis and structure-activity relationships of 4-hydroxy-4-phenylpiperidines as nociceptin receptor ligands: Part 1. DM2MPWC RU https://pubmed.ncbi.nlm.nih.gov/17428659 DM2MPWC DI DM2MPWC DM2MPWC DN 4-phenyl-1-(phenyl(o-tolyl)methyl)piperidin-4-ol DM2MPWC MI TTKWM86 DM2MPWC MN Opioid receptor mu (MOP) DM2MPWC MT DTT DM2MPWC MA Inhibitor DM2MPWC RN Bioorg Med Chem Lett. 2007 Jun 1;17(11):3023-7. Epub 2007 Mar 23.Synthesis and structure-activity relationships of 4-hydroxy-4-phenylpiperidines as nociceptin receptor ligands: Part 1. DM2MPWC RU https://pubmed.ncbi.nlm.nih.gov/17428659 DM5R6T4 DI DM5R6T4 DM5R6T4 DN 4-phenyl-1-(phenyl(p-tolyl)methyl)piperidin-4-ol DM5R6T4 MI TTNT7K8 DM5R6T4 MN Nociceptin receptor (OPRL1) DM5R6T4 MT DTT DM5R6T4 MA Inhibitor DM5R6T4 RN Bioorg Med Chem Lett. 2007 Jun 1;17(11):3023-7. Epub 2007 Mar 23.Synthesis and structure-activity relationships of 4-hydroxy-4-phenylpiperidines as nociceptin receptor ligands: Part 1. DM5R6T4 RU https://pubmed.ncbi.nlm.nih.gov/17428659 DM5R6T4 DI DM5R6T4 DM5R6T4 DN 4-phenyl-1-(phenyl(p-tolyl)methyl)piperidin-4-ol DM5R6T4 MI TT27RFC DM5R6T4 MN Opioid receptor delta (OPRD1) DM5R6T4 MT DTT DM5R6T4 MA Inhibitor DM5R6T4 RN Bioorg Med Chem Lett. 2007 Jun 1;17(11):3023-7. Epub 2007 Mar 23.Synthesis and structure-activity relationships of 4-hydroxy-4-phenylpiperidines as nociceptin receptor ligands: Part 1. DM5R6T4 RU https://pubmed.ncbi.nlm.nih.gov/17428659 DM5R6T4 DI DM5R6T4 DM5R6T4 DN 4-phenyl-1-(phenyl(p-tolyl)methyl)piperidin-4-ol DM5R6T4 MI TTQW87Y DM5R6T4 MN Opioid receptor kappa (OPRK1) DM5R6T4 MT DTT DM5R6T4 MA Inhibitor DM5R6T4 RN Bioorg Med Chem Lett. 2007 Jun 1;17(11):3023-7. Epub 2007 Mar 23.Synthesis and structure-activity relationships of 4-hydroxy-4-phenylpiperidines as nociceptin receptor ligands: Part 1. DM5R6T4 RU https://pubmed.ncbi.nlm.nih.gov/17428659 DM5R6T4 DI DM5R6T4 DM5R6T4 DN 4-phenyl-1-(phenyl(p-tolyl)methyl)piperidin-4-ol DM5R6T4 MI TTKWM86 DM5R6T4 MN Opioid receptor mu (MOP) DM5R6T4 MT DTT DM5R6T4 MA Inhibitor DM5R6T4 RN Bioorg Med Chem Lett. 2007 Jun 1;17(11):3023-7. Epub 2007 Mar 23.Synthesis and structure-activity relationships of 4-hydroxy-4-phenylpiperidines as nociceptin receptor ligands: Part 1. DM5R6T4 RU https://pubmed.ncbi.nlm.nih.gov/17428659 DMV6WC4 DI DMV6WC4 DMV6WC4 DN 4-phenyl-1,2,3,6-tetrahydropyridine DMV6WC4 MI TTGP7BY DMV6WC4 MN Monoamine oxidase type B (MAO-B) DMV6WC4 MT DTT DMV6WC4 MA Inhibitor DMV6WC4 RN Further explorations of unnatural alkaloids. J Nat Prod. 1985 Nov-Dec;48(6):878-93. DMV6WC4 RU https://pubmed.ncbi.nlm.nih.gov/3879267 DMONKDQ DI DMONKDQ DMONKDQ DN 4-phenyl-2-(phenylamino)pyrimidine-5-carbonitrile DMONKDQ MI TTH6V3D DMONKDQ MN Cyclin-dependent kinase 1 (CDK1) DMONKDQ MT DTT DMONKDQ MA Inhibitor DMONKDQ RN 4-Aryl-5-cyano-2-aminopyrimidines as VEGF-R2 inhibitors: synthesis and biological evaluation. Bioorg Med Chem Lett. 2007 Jun 15;17(12):3266-70. DMONKDQ RU https://pubmed.ncbi.nlm.nih.gov/17481894 DMONKDQ DI DMONKDQ DMONKDQ DN 4-phenyl-2-(phenylamino)pyrimidine-5-carbonitrile DMONKDQ MI TTUTJGQ DMONKDQ MN Vascular endothelial growth factor receptor 2 (KDR) DMONKDQ MT DTT DMONKDQ MA Inhibitor DMONKDQ RN 4-Aryl-5-cyano-2-aminopyrimidines as VEGF-R2 inhibitors: synthesis and biological evaluation. Bioorg Med Chem Lett. 2007 Jun 15;17(12):3266-70. DMONKDQ RU https://pubmed.ncbi.nlm.nih.gov/17481894 DMPY4G1 DI DMPY4G1 DMPY4G1 DN 4-phenyl-4-[1H-imidazol-2-yl]-piperidine DMPY4G1 MI TT27RFC DMPY4G1 MN Opioid receptor delta (OPRD1) DMPY4G1 MT DTT DMPY4G1 MA Inhibitor DMPY4G1 RN 4-Phenyl-4-[1H-imidazol-2-yl]-piperidine derivatives, a novel class of selective delta-opioid agonists. Bioorg Med Chem Lett. 2006 Jan 1;16(1):146-9. DMPY4G1 RU https://pubmed.ncbi.nlm.nih.gov/16236510 DMPY4G1 DI DMPY4G1 DMPY4G1 DN 4-phenyl-4-[1H-imidazol-2-yl]-piperidine DMPY4G1 MI TTQW87Y DMPY4G1 MN Opioid receptor kappa (OPRK1) DMPY4G1 MT DTT DMPY4G1 MA Inhibitor DMPY4G1 RN 4-Phenyl-4-[1H-imidazol-2-yl]-piperidine derivatives, a novel class of selective delta-opioid agonists. Bioorg Med Chem Lett. 2006 Jan 1;16(1):146-9. DMPY4G1 RU https://pubmed.ncbi.nlm.nih.gov/16236510 DM7E4JU DI DM7E4JU DM7E4JU DN 4-Phenyl-5-piperidin-4-yl-isoxazol-3-ol DM7E4JU MI TT1MPAY DM7E4JU MN GABA(A) receptor alpha-1 (GABRA1) DM7E4JU MT DTT DM7E4JU MA Inhibitor DM7E4JU RN Potent 4-aryl- or 4-arylalkyl-substituted 3-isoxazolol GABA(A) antagonists: synthesis, pharmacology, and molecular modeling. J Med Chem. 2005 Jan 27;48(2):427-39. DM7E4JU RU https://pubmed.ncbi.nlm.nih.gov/15658856 DM7E4JU DI DM7E4JU DM7E4JU DN 4-Phenyl-5-piperidin-4-yl-isoxazol-3-ol DM7E4JU MI TTZA1NY DM7E4JU MN GABA(A) receptor beta-2 (GABRB2) DM7E4JU MT DTT DM7E4JU MA Inhibitor DM7E4JU RN Potent 4-aryl- or 4-arylalkyl-substituted 3-isoxazolol GABA(A) antagonists: synthesis, pharmacology, and molecular modeling. J Med Chem. 2005 Jan 27;48(2):427-39. DM7E4JU RU https://pubmed.ncbi.nlm.nih.gov/15658856 DM7E4JU DI DM7E4JU DM7E4JU DN 4-Phenyl-5-piperidin-4-yl-isoxazol-3-ol DM7E4JU MI TT06RH5 DM7E4JU MN GABA(A) receptor gamma-2 (GABRG2) DM7E4JU MT DTT DM7E4JU MA Inhibitor DM7E4JU RN Potent 4-aryl- or 4-arylalkyl-substituted 3-isoxazolol GABA(A) antagonists: synthesis, pharmacology, and molecular modeling. J Med Chem. 2005 Jan 27;48(2):427-39. DM7E4JU RU https://pubmed.ncbi.nlm.nih.gov/15658856 DM7E4JU DI DM7E4JU DM7E4JU DN 4-Phenyl-5-piperidin-4-yl-isoxazol-3-ol DM7E4JU MI TTNJYV2 DM7E4JU MN Gamma-aminobutyric acid receptor (GAR) DM7E4JU MT DTT DM7E4JU MA Inhibitor DM7E4JU RN 4-aryl-5-(4-piperidyl)-3-isoxazolol GABAA antagonists: synthesis, pharmacology, and structure-activity relationships. J Med Chem. 2007 Apr 19;50(8):1988-92. DM7E4JU RU https://pubmed.ncbi.nlm.nih.gov/17375905 DMMIB0R DI DMMIB0R DMMIB0R DN 4-phenyl-6-propylpyrimidine-2-carbonitrile DMMIB0R MI TTDZN01 DMMIB0R MN Cathepsin K (CTSK) DMMIB0R MT DTT DMMIB0R MA Inhibitor DMMIB0R RN 2-Phenyl-9H-purine-6-carbonitrile derivatives as selective cathepsin S inhibitors. Bioorg Med Chem Lett. 2010 Aug 1;20(15):4447-50. DMMIB0R RU https://pubmed.ncbi.nlm.nih.gov/20594841 DMLZSH1 DI DMLZSH1 DMLZSH1 DN 4-Phenyl-benzo[b]thiophene-2-carboxamidine DMLZSH1 MI TTFEZ5Q DMLZSH1 MN Coagulation factor IX (F9) DMLZSH1 MT DTT DMLZSH1 MA Inhibitor DMLZSH1 RN Studies of benzothiophene template as potent factor IXa (FIXa) inhibitors in thrombosis. J Med Chem. 2010 Feb 25;53(4):1465-72. DMLZSH1 RU https://pubmed.ncbi.nlm.nih.gov/20121198 DM871ZE DI DM871ZE DM871ZE DN 4-Phenylbutylcarbamic Acid Biphenyl-3-yl Ester DM871ZE MI TTDP1UC DM871ZE MN Fatty acid amide hydrolase (FAAH) DM871ZE MT DTT DM871ZE MA Inhibitor DM871ZE RN Synthesis and quantitative structure-activity relationship of fatty acid amide hydrolase inhibitors: modulation at the N-portion of biphenyl-3-yl a... J Med Chem. 2008 Jun 26;51(12):3487-98. DM871ZE RU https://pubmed.ncbi.nlm.nih.gov/18507372 DMCZKN7 DI DMCZKN7 DMCZKN7 DN 4-Phenylbutyrohydroxamic acid DMCZKN7 MI TTBH0VX DMCZKN7 MN Histone deacetylase (HDAC) DMCZKN7 MT DTT DMCZKN7 MA Inhibitor DMCZKN7 RN Chemical phylogenetics of histone deacetylases. Nat Chem Biol. 2010 Mar;6(3):238-243. DMCZKN7 RU https://pubmed.ncbi.nlm.nih.gov/20139990 DMCZKN7 DI DMCZKN7 DMCZKN7 DN 4-Phenylbutyrohydroxamic acid DMCZKN7 MI TT6R7JZ DMCZKN7 MN Histone deacetylase 1 (HDAC1) DMCZKN7 MT DTT DMCZKN7 MA Inhibitor DMCZKN7 RN Chemical phylogenetics of histone deacetylases. Nat Chem Biol. 2010 Mar;6(3):238-243. DMCZKN7 RU https://pubmed.ncbi.nlm.nih.gov/20139990 DMCZKN7 DI DMCZKN7 DMCZKN7 DN 4-Phenylbutyrohydroxamic acid DMCZKN7 MI TTSHTOI DMCZKN7 MN Histone deacetylase 2 (HDAC2) DMCZKN7 MT DTT DMCZKN7 MA Inhibitor DMCZKN7 RN Chemical phylogenetics of histone deacetylases. Nat Chem Biol. 2010 Mar;6(3):238-243. DMCZKN7 RU https://pubmed.ncbi.nlm.nih.gov/20139990 DMCZKN7 DI DMCZKN7 DMCZKN7 DN 4-Phenylbutyrohydroxamic acid DMCZKN7 MI TT5ZKDI DMCZKN7 MN Histone deacetylase 6 (HDAC6) DMCZKN7 MT DTT DMCZKN7 MA Inhibitor DMCZKN7 RN Chemical phylogenetics of histone deacetylases. Nat Chem Biol. 2010 Mar;6(3):238-243. DMCZKN7 RU https://pubmed.ncbi.nlm.nih.gov/20139990 DMCZKN7 DI DMCZKN7 DMCZKN7 DN 4-Phenylbutyrohydroxamic acid DMCZKN7 MI TTT6LFV DMCZKN7 MN Histone deacetylase 8 (HDAC8) DMCZKN7 MT DTT DMCZKN7 MA Inhibitor DMCZKN7 RN Chemical phylogenetics of histone deacetylases. Nat Chem Biol. 2010 Mar;6(3):238-243. DMCZKN7 RU https://pubmed.ncbi.nlm.nih.gov/20139990 DM5UNBW DI DM5UNBW DM5UNBW DN 4-Phenylimidazole DM5UNBW MI TTZJYKH DM5UNBW MN Indoleamine 2,3-dioxygenase 1 (IDO1) DM5UNBW MT DTT DM5UNBW MA Inhibitor DM5UNBW RN Structure based development of phenylimidazole-derived inhibitors of indoleamine 2,3-dioxygenase. J Med Chem. 2008 Aug 28;51(16):4968-77. DM5UNBW RU https://pubmed.ncbi.nlm.nih.gov/18665584 DM9J5TZ DI DM9J5TZ DM9J5TZ DN 4-phenyliminomethyl-benzenesulfonamide DM9J5TZ MI TTVKILB DM9J5TZ MN Prostaglandin G/H synthase 2 (COX-2) DM9J5TZ MT DTT DM9J5TZ MA Inhibitor DM9J5TZ RN Selective COX-2 inhibitors. Part 2: synthesis and biological evaluation of 4-benzylideneamino- and 4-phenyliminomethyl-benzenesulfonamides. Bioorg Med Chem. 2008 Mar 1;16(5):2697-706. DM9J5TZ RU https://pubmed.ncbi.nlm.nih.gov/18063374 DMW46K7 DI DMW46K7 DMW46K7 DN 4-Phenylspiro[chromene-2,4'-piperidine] DMW46K7 MI TT27RFC DMW46K7 MN Opioid receptor delta (OPRD1) DMW46K7 MT DTT DMW46K7 MA Inhibitor DMW46K7 RN Potent, orally bioavailable delta opioid receptor agonists for the treatment of pain: discovery of N,N-diethyl-4-(5-hydroxyspiro[chromene-2,4'-pipe... J Med Chem. 2008 Oct 9;51(19):5893-6. DMW46K7 RU https://pubmed.ncbi.nlm.nih.gov/18788723 DMW46K7 DI DMW46K7 DMW46K7 DN 4-Phenylspiro[chromene-2,4'-piperidine] DMW46K7 MI TTQW87Y DMW46K7 MN Opioid receptor kappa (OPRK1) DMW46K7 MT DTT DMW46K7 MA Inhibitor DMW46K7 RN Potent, orally bioavailable delta opioid receptor agonists for the treatment of pain: discovery of N,N-diethyl-4-(5-hydroxyspiro[chromene-2,4'-pipe... J Med Chem. 2008 Oct 9;51(19):5893-6. DMW46K7 RU https://pubmed.ncbi.nlm.nih.gov/18788723 DMW46K7 DI DMW46K7 DMW46K7 DN 4-Phenylspiro[chromene-2,4'-piperidine] DMW46K7 MI TTQ6VDM DMW46K7 MN Voltage-gated potassium channel Kv11.1 (KCNH2) DMW46K7 MT DTT DMW46K7 MA Inhibitor DMW46K7 RN Potent, orally bioavailable delta opioid receptor agonists for the treatment of pain: discovery of N,N-diethyl-4-(5-hydroxyspiro[chromene-2,4'-pipe... J Med Chem. 2008 Oct 9;51(19):5893-6. DMW46K7 RU https://pubmed.ncbi.nlm.nih.gov/18788723 DMHANXD DI DMHANXD DMHANXD DN 4-Phenylsulfanyl-7H-pyrrolo[2,3-d]pyrimidine DMHANXD MI TT860QF DMHANXD MN LCK tyrosine protein kinase (LCK) DMHANXD MT DTT DMHANXD MA Inhibitor DMHANXD RN Synthesis and biological testing of purine derivatives as potential ATP-competitive kinase inhibitors. J Med Chem. 2005 Feb 10;48(3):710-22. DMHANXD RU https://pubmed.ncbi.nlm.nih.gov/15689155 DMHANXD DI DMHANXD DMHANXD DN 4-Phenylsulfanyl-7H-pyrrolo[2,3-d]pyrimidine DMHANXD MI TTQBR95 DMHANXD MN Stress-activated protein kinase 2a (p38 alpha) DMHANXD MT DTT DMHANXD MA Inhibitor DMHANXD RN Synthesis and biological testing of purine derivatives as potential ATP-competitive kinase inhibitors. J Med Chem. 2005 Feb 10;48(3):710-22. DMHANXD RU https://pubmed.ncbi.nlm.nih.gov/15689155 DM3B1CE DI DM3B1CE DM3B1CE DN 4-phenylthiazole-2-thiol DM3B1CE MI TTZJYKH DM3B1CE MN Indoleamine 2,3-dioxygenase 1 (IDO1) DM3B1CE MT DTT DM3B1CE MA Inhibitor DM3B1CE RN Rational design of indoleamine 2,3-dioxygenase inhibitors. J Med Chem. 2010 Feb 11;53(3):1172-89. DM3B1CE RU https://pubmed.ncbi.nlm.nih.gov/20055453 DMW4KXQ DI DMW4KXQ DMW4KXQ DN 4-phospho-D-erythronate DMW4KXQ MI TTZ3IFB DMW4KXQ MN Phosphogluconate dehydrogenase (PGD) DMW4KXQ MT DTT DMW4KXQ MA Inhibitor DMW4KXQ RN Virtual fragment screening for novel inhibitors of 6-phosphogluconate dehydrogenase. Bioorg Med Chem. 2010 Jul 15;18(14):5056-62. DMW4KXQ RU https://pubmed.ncbi.nlm.nih.gov/20598892 DMJ0A4Z DI DMJ0A4Z DMJ0A4Z DN 4'-Phosphopantetheine DMJ0A4Z MI TT4YO0Z DMJ0A4Z MN Phosphopantetheine adenylyltransferase (PPAT) DMJ0A4Z MT DTT DMJ0A4Z MA Inhibitor DMJ0A4Z RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMJ0A4Z RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMOHDRS DI DMOHDRS DMOHDRS DN 4-Piperidin-1-yl-chromen-2-one DMOHDRS MI TTK3PY9 DMOHDRS MN DNA-dependent protein kinase catalytic (PRKDC) DMOHDRS MT DTT DMOHDRS MA Inhibitor DMOHDRS RN Selective benzopyranone and pyrimido[2,1-a]isoquinolin-4-one inhibitors of DNA-dependent protein kinase: synthesis, structure-activity studies, and... J Med Chem. 2005 Jan 27;48(2):569-85. DMOHDRS RU https://pubmed.ncbi.nlm.nih.gov/15658870 DMONGDX DI DMONGDX DMONGDX DN 4-Piperidino-Piperidine DMONGDX MI TTMF541 DMONGDX MN Liver carboxylesterase (CES1) DMONGDX MT DTT DMONGDX MA Inhibitor DMONGDX RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DMONGDX RU https://pubmed.ncbi.nlm.nih.gov/10592235 DMEMN0W DI DMEMN0W DMEMN0W DN 4P-PDOT DMEMN0W MI TT0WAIE DMEMN0W MN Melatonin receptor type 1A (MTNR1A) DMEMN0W MT DTT DMEMN0W MA Antagonist DMEMN0W RN Selective MT2 melatonin receptor antagonists block melatonin-mediated phase advances of circadian rhythms. FASEB J. 1998 Sep;12(12):1211-20. DMEMN0W RU https://pubmed.ncbi.nlm.nih.gov/9737724 DMDBC1K DI DMDBC1K DMDBC1K DN 4-Propyl-1-[3-(phenylpropoxy)propyl]piperidine DMDBC1K MI TT9JNIC DMDBC1K MN Histamine H3 receptor (H3R) DMDBC1K MT DTT DMDBC1K MA Inhibitor DMDBC1K RN Piperidine variations in search for non-imidazole histamine H(3) receptor ligands. Bioorg Med Chem. 2008 Sep 15;16(18):8729-36. DMDBC1K RU https://pubmed.ncbi.nlm.nih.gov/18774720 DMRYCL6 DI DMRYCL6 DMRYCL6 DN 4-propyl-3,4-dihydroquinazolin-2-amine DMRYCL6 MI TTRUFDT DMRYCL6 MN 5-HT 5A receptor (HTR5A) DMRYCL6 MT DTT DMRYCL6 MA Inhibitor DMRYCL6 RN Cyclic guanidines as dual 5-HT5A/5-HT7 receptor ligands: structure-activity relationship elucidation. Bioorg Med Chem Lett. 2008 Jan 1;18(1):256-61. DMRYCL6 RU https://pubmed.ncbi.nlm.nih.gov/17998160 DMNM4GE DI DMNM4GE DMNM4GE DN 4-propyl-6-m-tolylpyrimidine-2-carbonitrile DMNM4GE MI TTDZN01 DMNM4GE MN Cathepsin K (CTSK) DMNM4GE MT DTT DMNM4GE MA Inhibitor DMNM4GE RN 2-Phenyl-9H-purine-6-carbonitrile derivatives as selective cathepsin S inhibitors. Bioorg Med Chem Lett. 2010 Aug 1;20(15):4447-50. DMNM4GE RU https://pubmed.ncbi.nlm.nih.gov/20594841 DMNM4GE DI DMNM4GE DMNM4GE DN 4-propyl-6-m-tolylpyrimidine-2-carbonitrile DMNM4GE MI TTUMQVO DMNM4GE MN Cathepsin S (CTSS) DMNM4GE MT DTT DMNM4GE MA Inhibitor DMNM4GE RN 2-Phenyl-9H-purine-6-carbonitrile derivatives as selective cathepsin S inhibitors. Bioorg Med Chem Lett. 2010 Aug 1;20(15):4447-50. DMNM4GE RU https://pubmed.ncbi.nlm.nih.gov/20594841 DM4FLK6 DI DM4FLK6 DM4FLK6 DN 4-propyl-N-(quinolin-3-yl)benzamide DM4FLK6 MI TTMI6F5 DM4FLK6 MN Transient receptor potential cation channel V1 (TRPV1) DM4FLK6 MT DTT DM4FLK6 MA Inhibitor DM4FLK6 RN N-pyridin-3-yl- and N-quinolin-3-yl-benzamides: modulators of human vanilloid receptor 1 (TRPV1). Bioorg Med Chem Lett. 2008 Apr 15;18(8):2730-4. DM4FLK6 RU https://pubmed.ncbi.nlm.nih.gov/18359227 DMY8ZLM DI DMY8ZLM DMY8ZLM DN 4-Pyridin-2-yl-5-quinolin-2-yl-thiazol-2-ylamine DMY8ZLM MI TTP4520 DMY8ZLM MN TGF-beta receptor type I (TGFBR1) DMY8ZLM MT DTT DMY8ZLM MA Inhibitor DMY8ZLM RN Identification of 1,5-naphthyridine derivatives as a novel series of potent and selective TGF-beta type I receptor inhibitors. J Med Chem. 2004 Aug 26;47(18):4494-506. DMY8ZLM RU https://pubmed.ncbi.nlm.nih.gov/15317461 DM6RVB3 DI DM6RVB3 DM6RVB3 DN 4-Pyridin-2-yl-5-quinolin-4-yl-thiazol-2-ylamine DM6RVB3 MI TTP4520 DM6RVB3 MN TGF-beta receptor type I (TGFBR1) DM6RVB3 MT DTT DM6RVB3 MA Inhibitor DM6RVB3 RN Identification of 1,5-naphthyridine derivatives as a novel series of potent and selective TGF-beta type I receptor inhibitors. J Med Chem. 2004 Aug 26;47(18):4494-506. DM6RVB3 RU https://pubmed.ncbi.nlm.nih.gov/15317461 DMFC8Q4 DI DMFC8Q4 DMFC8Q4 DN 4-Pyridin-2-yl-piperazine-1-carboxylic acid amide DMFC8Q4 MI TTMI6F5 DMFC8Q4 MN Transient receptor potential cation channel V1 (TRPV1) DMFC8Q4 MT DTT DMFC8Q4 MA Inhibitor DMFC8Q4 RN N-4-methansulfonamidobenzyl-N'-2-substituted-4-tert-butyl-benzyl thioureas as potent vanilloid receptor antagonistic ligands. Bioorg Med Chem Lett. 2004 Apr 5;14(7):1693-6. DMFC8Q4 RU https://pubmed.ncbi.nlm.nih.gov/15026052 DMFC8Q4 DI DMFC8Q4 DMFC8Q4 DN 4-Pyridin-2-yl-piperazine-1-carboxylic acid amide DMFC8Q4 MI TTKP2SU DMFC8Q4 MN Transient receptor potential cation channel V4 (TRPV4) DMFC8Q4 MT DTT DMFC8Q4 MA Inhibitor DMFC8Q4 RN N-4-methansulfonamidobenzyl-N'-2-substituted-4-tert-butyl-benzyl thioureas as potent vanilloid receptor antagonistic ligands. Bioorg Med Chem Lett. 2004 Apr 5;14(7):1693-6. DMFC8Q4 RU https://pubmed.ncbi.nlm.nih.gov/15026052 DM06AV8 DI DM06AV8 DM06AV8 DN 4-Pyridin-3-yl-5-quinolin-4-yl-thiazol-2-ylamine DM06AV8 MI TTP4520 DM06AV8 MN TGF-beta receptor type I (TGFBR1) DM06AV8 MT DTT DM06AV8 MA Inhibitor DM06AV8 RN Identification of 1,5-naphthyridine derivatives as a novel series of potent and selective TGF-beta type I receptor inhibitors. J Med Chem. 2004 Aug 26;47(18):4494-506. DM06AV8 RU https://pubmed.ncbi.nlm.nih.gov/15317461 DMUGFS3 DI DMUGFS3 DMUGFS3 DN 4r-Fluoro-N6-Ethanimidoyl-L-Lysine DMUGFS3 MI TTF10I9 DMUGFS3 MN Nitric-oxide synthase inducible (NOS2) DMUGFS3 MT DTT DMUGFS3 MA Inhibitor DMUGFS3 RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMUGFS3 RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMQNT8D DI DMQNT8D DMQNT8D DN 4S-4,5-Diamino-N-(4-phenoxyphenyl)pentanamide DMQNT8D MI TTXZEAJ DMQNT8D MN Leukotriene A-4 hydrolase (LTA4H) DMQNT8D MT DTT DMQNT8D MA Inhibitor DMQNT8D RN Synthesis of glutamic acid analogs as potent inhibitors of leukotriene A4 hydrolase. Bioorg Med Chem. 2008 May 1;16(9):4963-83. DMQNT8D RU https://pubmed.ncbi.nlm.nih.gov/18394906 DMELGKY DI DMELGKY DMELGKY DN 4-substituted 2,4-dioxobutanoic acids DMELGKY MI TTTG60L DMELGKY MN CAP-dependent endonuclease (CDE) DMELGKY MT DTT DMELGKY MA Inhibitor DMELGKY RN Anti-influenza virus activities of 4-substituted 2,4-dioxobutanoic acid inhibitors. Antimicrob Agents Chemother. 1996 May;40(5):1304-7. DMELGKY RU https://pubmed.ncbi.nlm.nih.gov/8723491 DMELGKY DI DMELGKY DMELGKY DN 4-substituted 2,4-dioxobutanoic acids DMELGKY MI TTV9MQG DMELGKY MN Gamma-aminobutyric acid uptake (GABAU) DMELGKY MT DTT DMELGKY MA Inhibitor DMELGKY RN GABA uptake inhibitors. Design, molecular pharmacology and therapeutic aspects. Curr Pharm Des. 2000 Aug;6(12):1193-209. DMELGKY RU https://pubmed.ncbi.nlm.nih.gov/10903390 DMWH2NT DI DMWH2NT DMWH2NT DN 4-Sulfamoyloxy-benzoic acid butyl ester DMWH2NT MI TTHM0R1 DMWH2NT MN Steryl-sulfatase (STS) DMWH2NT MT DTT DMWH2NT MA Inhibitor DMWH2NT RN Inhibition of estrone sulfatase (ES) by alkyl and cycloalkyl ester derivatives of 4-[(aminosulfonyl)oxy] benzoic acid. Bioorg Med Chem Lett. 2004 Feb 9;14(3):605-9. DMWH2NT RU https://pubmed.ncbi.nlm.nih.gov/14741252 DMDNRCU DI DMDNRCU DMDNRCU DN 4-Sulfamoyloxy-benzoic acid cycloheptyl ester DMDNRCU MI TTHM0R1 DMDNRCU MN Steryl-sulfatase (STS) DMDNRCU MT DTT DMDNRCU MA Inhibitor DMDNRCU RN Inhibition of estrone sulfatase (ES) by alkyl and cycloalkyl ester derivatives of 4-[(aminosulfonyl)oxy] benzoic acid. Bioorg Med Chem Lett. 2004 Feb 9;14(3):605-9. DMDNRCU RU https://pubmed.ncbi.nlm.nih.gov/14741252 DMIX0UN DI DMIX0UN DMIX0UN DN 4-Sulfamoyloxy-benzoic acid cyclohexyl ester DMIX0UN MI TTHM0R1 DMIX0UN MN Steryl-sulfatase (STS) DMIX0UN MT DTT DMIX0UN MA Inhibitor DMIX0UN RN Inhibition of estrone sulfatase (ES) by alkyl and cycloalkyl ester derivatives of 4-[(aminosulfonyl)oxy] benzoic acid. Bioorg Med Chem Lett. 2004 Feb 9;14(3):605-9. DMIX0UN RU https://pubmed.ncbi.nlm.nih.gov/14741252 DMG4LD9 DI DMG4LD9 DMG4LD9 DN 4-Sulfamoyloxy-benzoic acid cyclooctyl ester DMG4LD9 MI TTHM0R1 DMG4LD9 MN Steryl-sulfatase (STS) DMG4LD9 MT DTT DMG4LD9 MA Inhibitor DMG4LD9 RN Inhibition of estrone sulfatase (ES) by alkyl and cycloalkyl ester derivatives of 4-[(aminosulfonyl)oxy] benzoic acid. Bioorg Med Chem Lett. 2004 Feb 9;14(3):605-9. DMG4LD9 RU https://pubmed.ncbi.nlm.nih.gov/14741252 DMF3C71 DI DMF3C71 DMF3C71 DN 4-Sulfamoyloxy-benzoic acid cyclopentyl ester DMF3C71 MI TTHM0R1 DMF3C71 MN Steryl-sulfatase (STS) DMF3C71 MT DTT DMF3C71 MA Inhibitor DMF3C71 RN Inhibition of estrone sulfatase (ES) by alkyl and cycloalkyl ester derivatives of 4-[(aminosulfonyl)oxy] benzoic acid. Bioorg Med Chem Lett. 2004 Feb 9;14(3):605-9. DMF3C71 RU https://pubmed.ncbi.nlm.nih.gov/14741252 DMTC25W DI DMTC25W DMTC25W DN 4-Sulfamoyloxy-benzoic acid heptyl ester DMTC25W MI TTHM0R1 DMTC25W MN Steryl-sulfatase (STS) DMTC25W MT DTT DMTC25W MA Inhibitor DMTC25W RN Inhibition of estrone sulfatase (ES) by alkyl and cycloalkyl ester derivatives of 4-[(aminosulfonyl)oxy] benzoic acid. Bioorg Med Chem Lett. 2004 Feb 9;14(3):605-9. DMTC25W RU https://pubmed.ncbi.nlm.nih.gov/14741252 DMU784M DI DMU784M DMU784M DN 4-Sulfamoyloxy-benzoic acid hexyl ester DMU784M MI TTHM0R1 DMU784M MN Steryl-sulfatase (STS) DMU784M MT DTT DMU784M MA Inhibitor DMU784M RN Inhibition of estrone sulfatase (ES) by alkyl and cycloalkyl ester derivatives of 4-[(aminosulfonyl)oxy] benzoic acid. Bioorg Med Chem Lett. 2004 Feb 9;14(3):605-9. DMU784M RU https://pubmed.ncbi.nlm.nih.gov/14741252 DM4Z7TU DI DM4Z7TU DM4Z7TU DN 4-Sulfamoyloxy-benzoic acid nonyl ester DM4Z7TU MI TTHM0R1 DM4Z7TU MN Steryl-sulfatase (STS) DM4Z7TU MT DTT DM4Z7TU MA Inhibitor DM4Z7TU RN Inhibition of estrone sulfatase (ES) by alkyl and cycloalkyl ester derivatives of 4-[(aminosulfonyl)oxy] benzoic acid. Bioorg Med Chem Lett. 2004 Feb 9;14(3):605-9. DM4Z7TU RU https://pubmed.ncbi.nlm.nih.gov/14741252 DMQMSW3 DI DMQMSW3 DMQMSW3 DN 4-Sulfamoyloxy-benzoic acid octyl ester DMQMSW3 MI TTHM0R1 DMQMSW3 MN Steryl-sulfatase (STS) DMQMSW3 MT DTT DMQMSW3 MA Inhibitor DMQMSW3 RN Inhibition of estrone sulfatase (ES) by alkyl and cycloalkyl ester derivatives of 4-[(aminosulfonyl)oxy] benzoic acid. Bioorg Med Chem Lett. 2004 Feb 9;14(3):605-9. DMQMSW3 RU https://pubmed.ncbi.nlm.nih.gov/14741252 DMZIFW7 DI DMZIFW7 DMZIFW7 DN 4-Sulfamoyloxy-benzoic acid pentyl ester DMZIFW7 MI TTHM0R1 DMZIFW7 MN Steryl-sulfatase (STS) DMZIFW7 MT DTT DMZIFW7 MA Inhibitor DMZIFW7 RN Inhibition of estrone sulfatase (ES) by alkyl and cycloalkyl ester derivatives of 4-[(aminosulfonyl)oxy] benzoic acid. Bioorg Med Chem Lett. 2004 Feb 9;14(3):605-9. DMZIFW7 RU https://pubmed.ncbi.nlm.nih.gov/14741252 DMRILJC DI DMRILJC DMRILJC DN 4-Sulfamoyloxy-benzoic acid propyl ester DMRILJC MI TTHM0R1 DMRILJC MN Steryl-sulfatase (STS) DMRILJC MT DTT DMRILJC MA Inhibitor DMRILJC RN Inhibition of estrone sulfatase (ES) by alkyl and cycloalkyl ester derivatives of 4-[(aminosulfonyl)oxy] benzoic acid. Bioorg Med Chem Lett. 2004 Feb 9;14(3):605-9. DMRILJC RU https://pubmed.ncbi.nlm.nih.gov/14741252 DM61CJK DI DM61CJK DM61CJK DN 4-Sulfonamide-[1-(4-Aminobutane)]Benzamide DM61CJK MI TTANPDJ DM61CJK MN Carbonic anhydrase II (CA-II) DM61CJK MT DTT DM61CJK MA Inhibitor DM61CJK RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DM61CJK RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMGCYS1 DI DMGCYS1 DMGCYS1 DN 4-TERT-BUTYLBENZENESULFONIC ACID DMGCYS1 MI TT6L509 DMGCYS1 MN Coagulation factor IIa (F2) DMGCYS1 MT DTT DMGCYS1 MA Inhibitor DMGCYS1 RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DMGCYS1 RU https://pubmed.ncbi.nlm.nih.gov/10592235 DMDWRE5 DI DMDWRE5 DMDWRE5 DN 4-tert-butyl-N-(2-isopropylphenyl)thiazol-2-amine DMDWRE5 MI TT7HQD0 DMDWRE5 MN C-C chemokine receptor type 4 (CCR4) DMDWRE5 MT DTT DMDWRE5 MA Inhibitor DMDWRE5 RN Optimization of 2-aminothiazole derivatives as CCR4 antagonists. Bioorg Med Chem Lett. 2006 May 15;16(10):2800-3. DMDWRE5 RU https://pubmed.ncbi.nlm.nih.gov/16497499 DMLFZ6Q DI DMLFZ6Q DMLFZ6Q DN 4-tert-Butyl-N-(4-phenyl-thiazol-2-yl)-benzamide DMLFZ6Q MI TTK25J1 DMLFZ6Q MN Adenosine A1 receptor (ADORA1) DMLFZ6Q MT DTT DMLFZ6Q MA Inhibitor DMLFZ6Q RN Substituted 4-phenyl-2-(phenylcarboxamido)-1,3-thiazole derivatives as antagonists for the adenosine A(1) receptor. Bioorg Med Chem Lett. 2001 Aug 6;11(15):2017-9. DMLFZ6Q RU https://pubmed.ncbi.nlm.nih.gov/11454470 DM5U6ZW DI DM5U6ZW DM5U6ZW DN 4-tert-butyl-N-(naphthalen-1-yl)oxazol-2-amine DM5U6ZW MI TT7HQD0 DM5U6ZW MN C-C chemokine receptor type 4 (CCR4) DM5U6ZW MT DTT DM5U6ZW MA Inhibitor DM5U6ZW RN Optimization of 2-aminothiazole derivatives as CCR4 antagonists. Bioorg Med Chem Lett. 2006 May 15;16(10):2800-3. DM5U6ZW RU https://pubmed.ncbi.nlm.nih.gov/16497499 DMBUZ75 DI DMBUZ75 DMBUZ75 DN 4-tert-butyl-N-(naphthalen-1-yl)thiazol-2-amine DMBUZ75 MI TT7HQD0 DMBUZ75 MN C-C chemokine receptor type 4 (CCR4) DMBUZ75 MT DTT DMBUZ75 MA Inhibitor DMBUZ75 RN Optimization of 2-aminothiazole derivatives as CCR4 antagonists. Bioorg Med Chem Lett. 2006 May 15;16(10):2800-3. DMBUZ75 RU https://pubmed.ncbi.nlm.nih.gov/16497499 DM1OBHQ DI DM1OBHQ DM1OBHQ DN 4-tert-butyl-N-(quinolin-3-yl)benzamide DM1OBHQ MI TTMI6F5 DM1OBHQ MN Transient receptor potential cation channel V1 (TRPV1) DM1OBHQ MT DTT DM1OBHQ MA Inhibitor DM1OBHQ RN N-pyridin-3-yl- and N-quinolin-3-yl-benzamides: modulators of human vanilloid receptor 1 (TRPV1). Bioorg Med Chem Lett. 2008 Apr 15;18(8):2730-4. DM1OBHQ RU https://pubmed.ncbi.nlm.nih.gov/18359227 DMUWTPX DI DMUWTPX DMUWTPX DN 4-tert-butyl-N-hydroxybenzamide DMUWTPX MI TT6R7JZ DMUWTPX MN Histone deacetylase 1 (HDAC1) DMUWTPX MT DTT DMUWTPX MA Inhibitor DMUWTPX RN Design of novel histone deacetylase inhibitors. Bioorg Med Chem Lett. 2007 Aug 15;17(16):4619-24. DMUWTPX RU https://pubmed.ncbi.nlm.nih.gov/17555962 DM9K27Q DI DM9K27Q DM9K27Q DN 4-tert-butyl-N-m-tolylthiazol-2-amine DM9K27Q MI TT7HQD0 DM9K27Q MN C-C chemokine receptor type 4 (CCR4) DM9K27Q MT DTT DM9K27Q MA Inhibitor DM9K27Q RN Optimization of 2-aminothiazole derivatives as CCR4 antagonists. Bioorg Med Chem Lett. 2006 May 15;16(10):2800-3. DM9K27Q RU https://pubmed.ncbi.nlm.nih.gov/16497499 DMJQFD5 DI DMJQFD5 DMJQFD5 DN 4-tert-butyl-N-o-tolylthiazol-2-amine DMJQFD5 MI TT7HQD0 DMJQFD5 MN C-C chemokine receptor type 4 (CCR4) DMJQFD5 MT DTT DMJQFD5 MA Inhibitor DMJQFD5 RN Optimization of 2-aminothiazole derivatives as CCR4 antagonists. Bioorg Med Chem Lett. 2006 May 15;16(10):2800-3. DMJQFD5 RU https://pubmed.ncbi.nlm.nih.gov/16497499 DM5CPBK DI DM5CPBK DM5CPBK DN 4-tert-butyl-N-phenylthiazol-2-amine DM5CPBK MI TT7HQD0 DM5CPBK MN C-C chemokine receptor type 4 (CCR4) DM5CPBK MT DTT DM5CPBK MA Inhibitor DM5CPBK RN Optimization of 2-aminothiazole derivatives as CCR4 antagonists. Bioorg Med Chem Lett. 2006 May 15;16(10):2800-3. DM5CPBK RU https://pubmed.ncbi.nlm.nih.gov/16497499 DMUGMVI DI DMUGMVI DMUGMVI DN 4-Thiocyanato-benzenesulfonamide DMUGMVI MI TTUNARX DMUGMVI MN Carbonic anhydrase (CA) DMUGMVI MT DTT DMUGMVI MA Inhibitor DMUGMVI RN Carbonic anhydrase inhibitors: inhibition of human cytosolic isozyme II and mitochondrial isozyme V with a series of benzene sulfonamide derivatives. Bioorg Med Chem Lett. 2004 Nov 15;14(22):5703-7. DMUGMVI RU https://pubmed.ncbi.nlm.nih.gov/15482952 DMUGMVI DI DMUGMVI DMUGMVI DN 4-Thiocyanato-benzenesulfonamide DMUGMVI MI TTANPDJ DMUGMVI MN Carbonic anhydrase II (CA-II) DMUGMVI MT DTT DMUGMVI MA Inhibitor DMUGMVI RN Carbonic anhydrase inhibitors: inhibition of human cytosolic isozyme II and mitochondrial isozyme V with a series of benzene sulfonamide derivatives. Bioorg Med Chem Lett. 2004 Nov 15;14(22):5703-7. DMUGMVI RU https://pubmed.ncbi.nlm.nih.gov/15482952 DMA8SHN DI DMA8SHN DMA8SHN DN 4-Thiomorpholin-4-yl-benzo[g]chromen-2-one DMA8SHN MI TTK3PY9 DMA8SHN MN DNA-dependent protein kinase catalytic (PRKDC) DMA8SHN MT DTT DMA8SHN MA Inhibitor DMA8SHN RN Selective benzopyranone and pyrimido[2,1-a]isoquinolin-4-one inhibitors of DNA-dependent protein kinase: synthesis, structure-activity studies, and... J Med Chem. 2005 Jan 27;48(2):569-85. DMA8SHN RU https://pubmed.ncbi.nlm.nih.gov/15658870 DM7YOXW DI DM7YOXW DM7YOXW DN 4-thio-UTP DM7YOXW MI TTOZHQC DM7YOXW MN P2Y purinoceptor 2 (P2RY2) DM7YOXW MT DTT DM7YOXW MA Agonist DM7YOXW RN P2 receptors activated by uracil nucleotides--an update. Curr Med Chem. 2006;13(3):289-312. DM7YOXW RU https://pubmed.ncbi.nlm.nih.gov/16475938 DMT81SD DI DMT81SD DMT81SD DN 4'-trifluoromethyl-biphenyl-4-ylamine DMT81SD MI TTBGTCW DMT81SD MN Kinesin spindle messenger RNA (KIF11 mRNA) DMT81SD MT DTT DMT81SD MA Inhibitor DMT81SD RN Novel ATP-competitive kinesin spindle protein inhibitors. J Med Chem. 2007 Oct 4;50(20):4939-52. DMT81SD RU https://pubmed.ncbi.nlm.nih.gov/17725339 DML4DSG DI DML4DSG DML4DSG DN 5-((1H-imidazol-1-yl)methyl)-7,8-dihydroquinoline DML4DSG MI TTSZLWK DML4DSG MN Aromatase (CYP19A1) DML4DSG MT DTT DML4DSG MA Inhibitor DML4DSG RN Fast three dimensional pharmacophore virtual screening of new potent non-steroid aromatase inhibitors. J Med Chem. 2009 Jan 8;52(1):143-50. DML4DSG RU https://pubmed.ncbi.nlm.nih.gov/19072235 DMBSFLW DI DMBSFLW DMBSFLW DN 5-((6-Methylpyridin-2-yl)ethynyl)nicotinonitrile DMBSFLW MI TTHS256 DMBSFLW MN Metabotropic glutamate receptor 5 (mGluR5) DMBSFLW MT DTT DMBSFLW MA Inhibitor DMBSFLW RN Structure-activity relationships in a novel series of 7-substituted-aryl quinolines and 5-substituted-aryl benzothiazoles at the metabotropic gluta... Bioorg Med Chem. 2010 May 1;18(9):3026-35. DMBSFLW RU https://pubmed.ncbi.nlm.nih.gov/20382541 DMH0QA7 DI DMH0QA7 DMH0QA7 DN 5-((E)-Styryl)-quinazoline-2,4-diamine DMH0QA7 MI TT9SL3Q DMH0QA7 MN Polypeptide deformylase (PDF) DMH0QA7 MT DTT DMH0QA7 MA Inhibitor DMH0QA7 RN 2,4-Diamino-5-substituted-quinazolines as inhibitors of a human dihydrofolate reductase with a site-directed mutation at position 22 and of the dih... J Med Chem. 1995 Mar 3;38(5):745-52. DMH0QA7 RU https://pubmed.ncbi.nlm.nih.gov/7877140 DMT6D5V DI DMT6D5V DMT6D5V DN 5'-([(Z)-4-amino-2-butenyl]methylamino)-5'-deoxyadenosine DMT6D5V MI TTBFROQ DMT6D5V MN S-adenosylmethionine decarboxylase proenzyme (AMD1) DMT6D5V MT DTT DMT6D5V MA Inhibitor DMT6D5V RN S-adenosylmethionine decarboxylase as an enzyme target for therapy. Pharmacol Ther. 1992 Dec;56(3):359-77. DMT6D5V RU https://pubmed.ncbi.nlm.nih.gov/1301596 DMS31H9 DI DMS31H9 DMS31H9 DN 5-(1,1-dimethyl-heptyl)-2-pyridin-3-yl-phenol DMS31H9 MI TT6OEDT DMS31H9 MN Cannabinoid receptor 1 (CB1) DMS31H9 MT DTT DMS31H9 MA Inhibitor DMS31H9 RN Biaryl cannabinoid mimetics--synthesis and structure-activity relationship. Bioorg Med Chem Lett. 2007 Jul 1;17(13):3652-6. DMS31H9 RU https://pubmed.ncbi.nlm.nih.gov/17507224 DMS31H9 DI DMS31H9 DMS31H9 DN 5-(1,1-dimethyl-heptyl)-2-pyridin-3-yl-phenol DMS31H9 MI TTMSFAW DMS31H9 MN Cannabinoid receptor 2 (CB2) DMS31H9 MT DTT DMS31H9 MA Inhibitor DMS31H9 RN Biaryl cannabinoid mimetics--synthesis and structure-activity relationship. Bioorg Med Chem Lett. 2007 Jul 1;17(13):3652-6. DMS31H9 RU https://pubmed.ncbi.nlm.nih.gov/17507224 DMMSK9W DI DMMSK9W DMMSK9W DN 5-(1-Methyl-pyrrolidin-2-yl)-2-phenethyl-pyridine DMMSK9W MI TTF4E0J DMMSK9W MN Neuronal acetylcholine receptor alpha-2 (CHRNA2) DMMSK9W MT DTT DMMSK9W MA Inhibitor DMMSK9W RN 6-(2-Phenylethyl)nicotine: a novel nicotinic cholinergic receptor ligand. Bioorg Med Chem Lett. 2005 Jul 1;15(13):3237-40. DMMSK9W RU https://pubmed.ncbi.nlm.nih.gov/15925512 DMA2GIE DI DMA2GIE DMA2GIE DN 5-(2-(1H-imidazol-1-yl)ethyl)quinoline DMA2GIE MI TTSZLWK DMA2GIE MN Aromatase (CYP19A1) DMA2GIE MT DTT DMA2GIE MA Inhibitor DMA2GIE RN Fast three dimensional pharmacophore virtual screening of new potent non-steroid aromatase inhibitors. J Med Chem. 2009 Jan 8;52(1):143-50. DMA2GIE RU https://pubmed.ncbi.nlm.nih.gov/19072235 DMCFKGW DI DMCFKGW DMCFKGW DN 5-(2-(2,5-dimethylphenyl)ethynyl)pyrimidine DMCFKGW MI TTHS256 DMCFKGW MN Metabotropic glutamate receptor 5 (mGluR5) DMCFKGW MT DTT DMCFKGW MA Inhibitor DMCFKGW RN Synthesis and SAR of a mGluR5 allosteric partial antagonist lead: unexpected modulation of pharmacology with slight structural modifications to a 5... Bioorg Med Chem Lett. 2008 Jul 15;18(14):4098-101. DMCFKGW RU https://pubmed.ncbi.nlm.nih.gov/18550372 DM3XMKJ DI DM3XMKJ DM3XMKJ DN 5-(2-(3,5-difluorophenyl)ethynyl)pyrimidine DM3XMKJ MI TTHS256 DM3XMKJ MN Metabotropic glutamate receptor 5 (mGluR5) DM3XMKJ MT DTT DM3XMKJ MA Inhibitor DM3XMKJ RN Synthesis and SAR of a mGluR5 allosteric partial antagonist lead: unexpected modulation of pharmacology with slight structural modifications to a 5... Bioorg Med Chem Lett. 2008 Jul 15;18(14):4098-101. DM3XMKJ RU https://pubmed.ncbi.nlm.nih.gov/18550372 DM37KG6 DI DM37KG6 DM37KG6 DN 5-(2-(3-chlorophenyl)ethynyl)pyrimidine DM37KG6 MI TTHS256 DM37KG6 MN Metabotropic glutamate receptor 5 (mGluR5) DM37KG6 MT DTT DM37KG6 MA Inhibitor DM37KG6 RN Synthesis and SAR of a mGluR5 allosteric partial antagonist lead: unexpected modulation of pharmacology with slight structural modifications to a 5... Bioorg Med Chem Lett. 2008 Jul 15;18(14):4098-101. DM37KG6 RU https://pubmed.ncbi.nlm.nih.gov/18550372 DMRS1Q5 DI DMRS1Q5 DMRS1Q5 DN 5-(2-(4-fluoro-3-methylphenyl)ethynyl)pyrimidine DMRS1Q5 MI TTHS256 DMRS1Q5 MN Metabotropic glutamate receptor 5 (mGluR5) DMRS1Q5 MT DTT DMRS1Q5 MA Inhibitor DMRS1Q5 RN Synthesis and SAR of a mGluR5 allosteric partial antagonist lead: unexpected modulation of pharmacology with slight structural modifications to a 5... Bioorg Med Chem Lett. 2008 Jul 15;18(14):4098-101. DMRS1Q5 RU https://pubmed.ncbi.nlm.nih.gov/18550372 DMXAF7Y DI DMXAF7Y DMXAF7Y DN 5-(2-(pyrrolidin-1-yl)ethyl)isothiazole DMXAF7Y MI TT9JNIC DMXAF7Y MN Histamine H3 receptor (H3R) DMXAF7Y MT DTT DMXAF7Y MA Inhibitor DMXAF7Y RN In vitro SAR of pyrrolidine-containing histamine H3 receptor antagonists: trends across multiple chemical series. Bioorg Med Chem Lett. 2008 Jan 1;18(1):355-9. DMXAF7Y RU https://pubmed.ncbi.nlm.nih.gov/18077160 DM149IX DI DM149IX DM149IX DN 5-(2-1H-indenyl)-1,3-benzodioxole DM149IX MI TT8NGED DM149IX MN Prostaglandin G/H synthase 1 (COX-1) DM149IX MT DTT DM149IX MA Inhibitor DM149IX RN 'Bridged' stilbene derivatives as selective cyclooxygenase-1 inhibitors. Bioorg Med Chem. 2007 Sep 15;15(18):6109-18. DM149IX RU https://pubmed.ncbi.nlm.nih.gov/17604631 DMJXI65 DI DMJXI65 DMJXI65 DN 5-(2-Amino-ethyl)-2-chloro-phenol hydrobromide DMJXI65 MI TTZFYLI DMJXI65 MN Dopamine D1 receptor (D1R) DMJXI65 MT DTT DMJXI65 MA Inhibitor DMJXI65 RN Synthesis and pharmacological characterization of 2-(4-chloro-3-hydroxyphenyl)ethylamine and N,N-dialkyl derivatives as dopamine receptor ligands. J Med Chem. 1992 Nov 13;35(23):4408-14. DMJXI65 RU https://pubmed.ncbi.nlm.nih.gov/1360027 DMQCYEK DI DMQCYEK DMQCYEK DN 5-(2-fluorobenzyloxy)quinazoline-2,4-diamine DMQCYEK MI TT9SL3Q DMQCYEK MN Polypeptide deformylase (PDF) DMQCYEK MT DTT DMQCYEK MA Inhibitor DMQCYEK RN Synthesis and biological evaluation of novel 2,4-diaminoquinazoline derivatives as SMN2 promoter activators for the potential treatment of spinal m... J Med Chem. 2008 Feb 14;51(3):449-69. DMQCYEK RU https://pubmed.ncbi.nlm.nih.gov/18205293 DMHBD1T DI DMHBD1T DMHBD1T DN 5-(2-hydroxyethyl)nonane-1,9-diol DMHBD1T MI TTQ9RYT DMHBD1T MN Endothelin-converting enzyme 1 (ECE1) DMHBD1T MT DTT DMHBD1T MA Inhibitor DMHBD1T RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DMHBD1T RU https://pubmed.ncbi.nlm.nih.gov/10592235 DMCP5U8 DI DMCP5U8 DMCP5U8 DN 5-(2-Imidazol-1-yl-ethyl)-7,8-dihydro-quinoline DMCP5U8 MI TT8NGED DMCP5U8 MN Prostaglandin G/H synthase 1 (COX-1) DMCP5U8 MT DTT DMCP5U8 MA Inhibitor DMCP5U8 RN 1-imidazolyl(alkyl)-substituted di- and tetrahydroquinolines and analogues: syntheses and evaluation of dual inhibitors of thromboxane A(2) synthas... J Med Chem. 2000 May 4;43(9):1841-51. DMCP5U8 RU https://pubmed.ncbi.nlm.nih.gov/10794700 DMCP5U8 DI DMCP5U8 DMCP5U8 DN 5-(2-Imidazol-1-yl-ethyl)-7,8-dihydro-quinoline DMCP5U8 MI TTVKILB DMCP5U8 MN Prostaglandin G/H synthase 2 (COX-2) DMCP5U8 MT DTT DMCP5U8 MA Inhibitor DMCP5U8 RN 1-imidazolyl(alkyl)-substituted di- and tetrahydroquinolines and analogues: syntheses and evaluation of dual inhibitors of thromboxane A(2) synthas... J Med Chem. 2000 May 4;43(9):1841-51. DMCP5U8 RU https://pubmed.ncbi.nlm.nih.gov/10794700 DMCP5U8 DI DMCP5U8 DMCP5U8 DN 5-(2-Imidazol-1-yl-ethyl)-7,8-dihydro-quinoline DMCP5U8 MI TTKNWZ4 DMCP5U8 MN Thromboxane-A synthase (TBXAS1) DMCP5U8 MT DTT DMCP5U8 MA Inhibitor DMCP5U8 RN 1-imidazolyl(alkyl)-substituted di- and tetrahydroquinolines and analogues: syntheses and evaluation of dual inhibitors of thromboxane A(2) synthas... J Med Chem. 2000 May 4;43(9):1841-51. DMCP5U8 RU https://pubmed.ncbi.nlm.nih.gov/10794700 DMV3KBE DI DMV3KBE DMV3KBE DN 5-(2-methylpiperazin-1-ylsulfonyl)isoquinoline DMV3KBE MI TTNAHEX DMV3KBE MN cAMP-dependent protein kinase A type I (PRKAR1A) DMV3KBE MT DTT DMV3KBE MA Inhibitor DMV3KBE RN Crystal structures of catalytic subunit of cAMP-dependent protein kinase in complex with isoquinolinesulfonyl protein kinase inhibitors H7, H8, and... J Biol Chem. 1996 Oct 18;271(42):26157-64. DMV3KBE RU https://pubmed.ncbi.nlm.nih.gov/8824261 DMIQJM4 DI DMIQJM4 DMIQJM4 DN 5-(2-Methylquinolin-7-yl)-2-phenylbenzonitrile DMIQJM4 MI TTHS256 DMIQJM4 MN Metabotropic glutamate receptor 5 (mGluR5) DMIQJM4 MT DTT DMIQJM4 MA Inhibitor DMIQJM4 RN Structure-activity relationships in a novel series of 7-substituted-aryl quinolines and 5-substituted-aryl benzothiazoles at the metabotropic gluta... Bioorg Med Chem. 2010 May 1;18(9):3026-35. DMIQJM4 RU https://pubmed.ncbi.nlm.nih.gov/20382541 DMO74HX DI DMO74HX DMO74HX DN 5-(2-Methylquinolin-7-yl)-2-phenylnicotinonitrile DMO74HX MI TTHS256 DMO74HX MN Metabotropic glutamate receptor 5 (mGluR5) DMO74HX MT DTT DMO74HX MA Inhibitor DMO74HX RN Structure-activity relationships in a novel series of 7-substituted-aryl quinolines and 5-substituted-aryl benzothiazoles at the metabotropic gluta... Bioorg Med Chem. 2010 May 1;18(9):3026-35. DMO74HX RU https://pubmed.ncbi.nlm.nih.gov/20382541 DMMX69H DI DMMX69H DMMX69H DN 5-(2-methylquinolin-7-yl)isophthalonitrile DMMX69H MI TTHS256 DMMX69H MN Metabotropic glutamate receptor 5 (mGluR5) DMMX69H MT DTT DMMX69H MA Inhibitor DMMX69H RN Rational design of 7-arylquinolines as non-competitive metabotropic glutamate receptor subtype 5 antagonists. Bioorg Med Chem Lett. 2007 Aug 15;17(16):4415-8. DMMX69H RU https://pubmed.ncbi.nlm.nih.gov/17590335 DM8LN2X DI DM8LN2X DM8LN2X DN 5-(2-methylquinolin-7-yl)nicotinonitrile DM8LN2X MI TTHS256 DM8LN2X MN Metabotropic glutamate receptor 5 (mGluR5) DM8LN2X MT DTT DM8LN2X MA Inhibitor DM8LN2X RN Rational design of 7-arylquinolines as non-competitive metabotropic glutamate receptor subtype 5 antagonists. Bioorg Med Chem Lett. 2007 Aug 15;17(16):4415-8. DM8LN2X RU https://pubmed.ncbi.nlm.nih.gov/17590335 DMO5WG8 DI DMO5WG8 DMO5WG8 DN 5-(2-m-tolylethynyl)pyrimidine DMO5WG8 MI TTHS256 DMO5WG8 MN Metabotropic glutamate receptor 5 (mGluR5) DMO5WG8 MT DTT DMO5WG8 MA Inhibitor DMO5WG8 RN Synthesis and SAR of a mGluR5 allosteric partial antagonist lead: unexpected modulation of pharmacology with slight structural modifications to a 5... Bioorg Med Chem Lett. 2008 Jul 15;18(14):4098-101. DMO5WG8 RU https://pubmed.ncbi.nlm.nih.gov/18550372 DMR7OHB DI DMR7OHB DMR7OHB DN 5-(2-oxoindolin-5-yl)-1H-pyrrole-2-carbonitrile DMR7OHB MI TTUV8G9 DMR7OHB MN Progesterone receptor (PGR) DMR7OHB MT DTT DMR7OHB MA Inhibitor DMR7OHB RN Design, synthesis, and SAR of new pyrrole-oxindole progesterone receptor modulators leading to 5-(7-fluoro-3,3-dimethyl-2-oxo-2,3-dihydro-1H-indol-... J Med Chem. 2008 Mar 27;51(6):1861-73. DMR7OHB RU https://pubmed.ncbi.nlm.nih.gov/18318463 DM07P5E DI DM07P5E DM07P5E DN 5-(2-phenethylpiperazin-1-yl)-1H-indazole DM07P5E MI TTXV4FI DM07P5E MN Albendazole monooxygenase (CYP3A4) DM07P5E MT DTT DM07P5E MA Inhibitor DM07P5E RN 2-Substituted N-aryl piperazines as novel triple reuptake inhibitors for the treatment of depression, Bioorg. Med. Chem. Lett. 20(13):3941-3945 (2010). DM07P5E RU http://www.sciencedirect.com/science/article/pii/S0960894X10006372 DMR35OM DI DMR35OM DMR35OM DN 5-(3-(4-fluorobenzyl)pyrrolidin-3-yl)-1H-indole DMR35OM MI TTQ6VDM DMR35OM MN Voltage-gated potassium channel Kv11.1 (KCNH2) DMR35OM MT DTT DMR35OM MA Inhibitor DMR35OM RN Novel 3,3-disubstituted pyrrolidines as selective triple serotonin/norepinephrine/dopamine reuptake inhibitors. Bioorg Med Chem Lett. 2008 Dec 1;18(23):6062-6. DMR35OM RU https://pubmed.ncbi.nlm.nih.gov/18954985 DMRF0PS DI DMRF0PS DMRF0PS DN 5-(3,4-dichlorophenyl)-1H-pyrazol-3-ol DMRF0PS MI TTEAID7 DMRF0PS MN Trypanosoma Cruzipain (Trypano CYSP) DMRF0PS MT DTT DMRF0PS MA Inhibitor DMRF0PS RN Quantitative analyses of aggregation, autofluorescence, and reactivity artifacts in a screen for inhibitors of a thiol protease. J Med Chem. 2010 Jan 14;53(1):37-51. DMRF0PS RU https://pubmed.ncbi.nlm.nih.gov/19908840 DMZK4AH DI DMZK4AH DMZK4AH DN 5-(3-benzylpyrrolidin-3-yl)-1h-indole (structural mix) DMZK4AH MI TTQ6VDM DMZK4AH MN Voltage-gated potassium channel Kv11.1 (KCNH2) DMZK4AH MT DTT DMZK4AH MA Inhibitor DMZK4AH RN Novel 3,3-disubstituted pyrrolidines as selective triple serotonin/norepinephrine/dopamine reuptake inhibitors. Bioorg Med Chem Lett. 2008 Dec 1;18(23):6062-6. DMZK4AH RU https://pubmed.ncbi.nlm.nih.gov/18954985 DM2ZUFO DI DM2ZUFO DM2ZUFO DN 5-(3-benzylpyrrolidin-3-yl)-1-methyl-1H-indole DM2ZUFO MI TTQ6VDM DM2ZUFO MN Voltage-gated potassium channel Kv11.1 (KCNH2) DM2ZUFO MT DTT DM2ZUFO MA Inhibitor DM2ZUFO RN Novel 3,3-disubstituted pyrrolidines as selective triple serotonin/norepinephrine/dopamine reuptake inhibitors. Bioorg Med Chem Lett. 2008 Dec 1;18(23):6062-6. DM2ZUFO RU https://pubmed.ncbi.nlm.nih.gov/18954985 DMPKGJC DI DMPKGJC DMPKGJC DN 5-(3-butylpyrrolidin-3-yl)-1H-indole DMPKGJC MI TTQ6VDM DMPKGJC MN Voltage-gated potassium channel Kv11.1 (KCNH2) DMPKGJC MT DTT DMPKGJC MA Inhibitor DMPKGJC RN Novel 3,3-disubstituted pyrrolidines as selective triple serotonin/norepinephrine/dopamine reuptake inhibitors. Bioorg Med Chem Lett. 2008 Dec 1;18(23):6062-6. DMPKGJC RU https://pubmed.ncbi.nlm.nih.gov/18954985 DMCR9KX DI DMCR9KX DMCR9KX DN 5-(3-Chloro-benzyl)-1H-pyrazole-3-carboxylic acid DMCR9KX MI TTWNV8U DMCR9KX MN Nicotinic acid receptor (HCAR2) DMCR9KX MT DTT DMCR9KX MA Inhibitor DMCR9KX RN Pyrazole derivatives as partial agonists for the nicotinic acid receptor. J Med Chem. 2003 Aug 28;46(18):3945-51. DMCR9KX RU https://pubmed.ncbi.nlm.nih.gov/12930155 DMABSOC DI DMABSOC DMABSOC DN 5-(3-chlorophenylethynyl)-5-methyl[1,2,4]triazine DMABSOC MI TTHS256 DMABSOC MN Metabotropic glutamate receptor 5 (mGluR5) DMABSOC MT DTT DMABSOC MA Inhibitor DMABSOC RN Synthesis and pharmacological evaluation of phenylethynyl[1,2,4]methyltriazines as analogues of 3-methyl-6-(phenylethynyl)pyridine. J Med Chem. 2007 Jul 12;50(14):3388-91. DMABSOC RU https://pubmed.ncbi.nlm.nih.gov/17569516 DMPC9DV DI DMPC9DV DMPC9DV DN 5-(3'-cyanobiphenyl-4-yl)-3-hydroxypentanoic acid DMPC9DV MI TTXZ0KQ DMPC9DV MN Matrix metalloproteinase-12 (MMP-12) DMPC9DV MT DTT DMPC9DV MA Inhibitor DMPC9DV RN The identification of beta-hydroxy carboxylic acids as selective MMP-12 inhibitors. Bioorg Med Chem Lett. 2009 Oct 1;19(19):5760-3. DMPC9DV RU https://pubmed.ncbi.nlm.nih.gov/19703773 DM2H9ND DI DM2H9ND DM2H9ND DN 5-(3-hydroxyphenyl)-1,3,4-oxadiazole-2(3H)-thione DM2H9ND MI TTULVH8 DM2H9ND MN Tyrosinase (TYR) DM2H9ND MT DTT DM2H9ND MA Inhibitor DM2H9ND RN New potent inhibitors of tyrosinase: novel clues to binding of 1,3,4-thiadiazole-2(3H)-thiones, 1,3,4-oxadiazole-2(3H)-thiones, 4-amino-1,2,4-triaz... Bioorg Med Chem. 2010 Jun 1;18(11):4042-8. DM2H9ND RU https://pubmed.ncbi.nlm.nih.gov/20452224 DMPCFA6 DI DMPCFA6 DMPCFA6 DN 5-(3-Phenyl-propyl)-1H-pyrazole-3-carboxylic acid DMPCFA6 MI TTWNV8U DMPCFA6 MN Nicotinic acid receptor (HCAR2) DMPCFA6 MT DTT DMPCFA6 MA Inhibitor DMPCFA6 RN Pyrazole derivatives as partial agonists for the nicotinic acid receptor. J Med Chem. 2003 Aug 28;46(18):3945-51. DMPCFA6 RU https://pubmed.ncbi.nlm.nih.gov/12930155 DMZYE8W DI DMZYE8W DMZYE8W DN 5-(4-((phenethylamino)methyl)phenoxy)picolinamide DMZYE8W MI TT27RFC DMZYE8W MN Opioid receptor delta (OPRD1) DMZYE8W MT DTT DMZYE8W MA Inhibitor DMZYE8W RN Structure-activity relationship studies of carboxamido-biaryl ethers as opioid receptor antagonists (OpRAs). Part 1. Bioorg Med Chem Lett. 2007 Oct 1;17(19):5349-52. DMZYE8W RU https://pubmed.ncbi.nlm.nih.gov/17720493 DMZYE8W DI DMZYE8W DMZYE8W DN 5-(4-((phenethylamino)methyl)phenoxy)picolinamide DMZYE8W MI TTQW87Y DMZYE8W MN Opioid receptor kappa (OPRK1) DMZYE8W MT DTT DMZYE8W MA Inhibitor DMZYE8W RN Structure-activity relationship studies of carboxamido-biaryl ethers as opioid receptor antagonists (OpRAs). Part 1. Bioorg Med Chem Lett. 2007 Oct 1;17(19):5349-52. DMZYE8W RU https://pubmed.ncbi.nlm.nih.gov/17720493 DMZYE8W DI DMZYE8W DMZYE8W DN 5-(4-((phenethylamino)methyl)phenoxy)picolinamide DMZYE8W MI TTKWM86 DMZYE8W MN Opioid receptor mu (MOP) DMZYE8W MT DTT DMZYE8W MA Inhibitor DMZYE8W RN Structure-activity relationship studies of carboxamido-biaryl ethers as opioid receptor antagonists (OpRAs). Part 1. Bioorg Med Chem Lett. 2007 Oct 1;17(19):5349-52. DMZYE8W RU https://pubmed.ncbi.nlm.nih.gov/17720493 DM6KSN9 DI DM6KSN9 DM6KSN9 DN 5-(4'-benzoylbiphenyl-4-yl)-2-furoic acid DM6KSN9 MI TT9INHD DM6KSN9 MN Creatine kinase (CK) DM6KSN9 MT DTT DM6KSN9 MA Inhibitor DM6KSN9 RN NMR screening applied to the fragment-based generation of inhibitors of creatine kinase exploiting a new interaction proximate to the ATP binding s... J Med Chem. 2007 Apr 19;50(8):1865-75. DM6KSN9 RU https://pubmed.ncbi.nlm.nih.gov/17375903 DMT4856 DI DMT4856 DMT4856 DN 5-(4-bromophenyl)-2-furaldehyde thiosemicarbazone DMT4856 MI TTEAID7 DMT4856 MN Trypanosoma Cruzipain (Trypano CYSP) DMT4856 MT DTT DMT4856 MA Inhibitor DMT4856 RN Synthesis and structure-activity relationship study of potent trypanocidal thio semicarbazone inhibitors of the trypanosomal cysteine protease cruz... J Med Chem. 2002 Jun 20;45(13):2695-707. DMT4856 RU https://pubmed.ncbi.nlm.nih.gov/12061873 DMDCNZE DI DMDCNZE DMDCNZE DN 5-(4-Chloro-benzyl)-1H-pyrazole-3-carboxylic acid DMDCNZE MI TTWNV8U DMDCNZE MN Nicotinic acid receptor (HCAR2) DMDCNZE MT DTT DMDCNZE MA Inhibitor DMDCNZE RN Pyrazole derivatives as partial agonists for the nicotinic acid receptor. J Med Chem. 2003 Aug 28;46(18):3945-51. DMDCNZE RU https://pubmed.ncbi.nlm.nih.gov/12930155 DMJKAF0 DI DMJKAF0 DMJKAF0 DN 5-(4-Chloro-phenyl)-1-methyl-piperidin-2-one DMJKAF0 MI TTTU72V DMJKAF0 MN Steroid 5-alpha-reductase 1 (SRD5A1) DMJKAF0 MT DTT DMJKAF0 MA Inhibitor DMJKAF0 RN Simple bi- and tricyclic inhibitors of human steroid 5alpha-reductase. Bioorg Med Chem Lett. 2000 Sep 4;10(17):1909-11. DMJKAF0 RU https://pubmed.ncbi.nlm.nih.gov/10987415 DMQB1UI DI DMQB1UI DMQB1UI DN 5-(4-Chloro-phenyl)-1-methyl-piperidine-2-thione DMQB1UI MI TTTU72V DMQB1UI MN Steroid 5-alpha-reductase 1 (SRD5A1) DMQB1UI MT DTT DMQB1UI MA Inhibitor DMQB1UI RN Simple bi- and tricyclic inhibitors of human steroid 5alpha-reductase. Bioorg Med Chem Lett. 2000 Sep 4;10(17):1909-11. DMQB1UI RU https://pubmed.ncbi.nlm.nih.gov/10987415 DMSTG03 DI DMSTG03 DMSTG03 DN 5-(4-Chlorophenyl)-4-(4-methoxyphenyl)isothiazole DMSTG03 MI TT8NGED DMSTG03 MN Prostaglandin G/H synthase 1 (COX-1) DMSTG03 MT DTT DMSTG03 MA Inhibitor DMSTG03 RN Diaryl-dithiolanes and -isothiazoles: COX-1/COX-2 and 5-LOX-inhibitory, *OH scavenging and anti-adhesive activities. Bioorg Med Chem. 2009 Jan 15;17(2):558-68. DMSTG03 RU https://pubmed.ncbi.nlm.nih.gov/19097798 DMY0P86 DI DMY0P86 DMY0P86 DN 5-(4-Chlorophenyl)-4-p-tolyl-1,2-selenazole DMY0P86 MI TT8NGED DMY0P86 MN Prostaglandin G/H synthase 1 (COX-1) DMY0P86 MT DTT DMY0P86 MA Inhibitor DMY0P86 RN Investigations concerning the COX/5-LOX inhibiting and hydroxyl radical scavenging potencies of novel 4,5-diaryl isoselenazoles. Eur J Med Chem. 2008 Jun;43(6):1152-9. DMY0P86 RU https://pubmed.ncbi.nlm.nih.gov/17976864 DMY0P86 DI DMY0P86 DMY0P86 DN 5-(4-Chlorophenyl)-4-p-tolyl-1,2-selenazole DMY0P86 MI TTVKILB DMY0P86 MN Prostaglandin G/H synthase 2 (COX-2) DMY0P86 MT DTT DMY0P86 MA Inhibitor DMY0P86 RN Investigations concerning the COX/5-LOX inhibiting and hydroxyl radical scavenging potencies of novel 4,5-diaryl isoselenazoles. Eur J Med Chem. 2008 Jun;43(6):1152-9. DMY0P86 RU https://pubmed.ncbi.nlm.nih.gov/17976864 DMFYEL8 DI DMFYEL8 DMFYEL8 DN 5-(4-Chlorophenyl)-4-p-tolyl-3H-1,2-dithiol-3-one DMFYEL8 MI TT8NGED DMFYEL8 MN Prostaglandin G/H synthase 1 (COX-1) DMFYEL8 MT DTT DMFYEL8 MA Inhibitor DMFYEL8 RN Diaryl-dithiolanes and -isothiazoles: COX-1/COX-2 and 5-LOX-inhibitory, *OH scavenging and anti-adhesive activities. Bioorg Med Chem. 2009 Jan 15;17(2):558-68. DMFYEL8 RU https://pubmed.ncbi.nlm.nih.gov/19097798 DMA1N75 DI DMA1N75 DMA1N75 DN 5-(4-Chlorophenyl)-4-p-tolylisothiazole DMA1N75 MI TT8NGED DMA1N75 MN Prostaglandin G/H synthase 1 (COX-1) DMA1N75 MT DTT DMA1N75 MA Inhibitor DMA1N75 RN Diaryl-dithiolanes and -isothiazoles: COX-1/COX-2 and 5-LOX-inhibitory, *OH scavenging and anti-adhesive activities. Bioorg Med Chem. 2009 Jan 15;17(2):558-68. DMA1N75 RU https://pubmed.ncbi.nlm.nih.gov/19097798 DMV7HA1 DI DMV7HA1 DMV7HA1 DN 5-(4-chlorophenyl)-N-(2-methylbenzyl)nicotinamide DMV7HA1 MI TT90XZ8 DMV7HA1 MN Voltage-gated sodium channel alpha Nav1.8 (SCN10A) DMV7HA1 MT DTT DMV7HA1 MA Inhibitor DMV7HA1 RN Subtype-selective Na(v)1.8 sodium channel blockers: identification of potent, orally active nicotinamide derivatives. Bioorg Med Chem Lett. 2010 Nov 15;20(22):6812-5. DMV7HA1 RU https://pubmed.ncbi.nlm.nih.gov/20855211 DM6CRVS DI DM6CRVS DM6CRVS DN 5-(4-Chloro-phenyl)-pentanoic acid hydroxyamide DM6CRVS MI TTBH0VX DM6CRVS MN Histone deacetylase (HDAC) DM6CRVS MT DTT DM6CRVS MA Inhibitor DM6CRVS RN Stereodefined and polyunsaturated inhibitors of histone deacetylase based on (2E,4E)-5-arylpenta-2,4-dienoic acid hydroxyamides. Bioorg Med Chem Lett. 2004 May 17;14(10):2477-81. DM6CRVS RU https://pubmed.ncbi.nlm.nih.gov/15109636 DM6CRVS DI DM6CRVS DM6CRVS DN 5-(4-Chloro-phenyl)-pentanoic acid hydroxyamide DM6CRVS MI TT6R7JZ DM6CRVS MN Histone deacetylase 1 (HDAC1) DM6CRVS MT DTT DM6CRVS MA Inhibitor DM6CRVS RN Stereodefined and polyunsaturated inhibitors of histone deacetylase based on (2E,4E)-5-arylpenta-2,4-dienoic acid hydroxyamides. Bioorg Med Chem Lett. 2004 May 17;14(10):2477-81. DM6CRVS RU https://pubmed.ncbi.nlm.nih.gov/15109636 DM6CRVS DI DM6CRVS DM6CRVS DN 5-(4-Chloro-phenyl)-pentanoic acid hydroxyamide DM6CRVS MI TTYHPU6 DM6CRVS MN Histone deacetylase 10 (HDAC10) DM6CRVS MT DTT DM6CRVS MA Inhibitor DM6CRVS RN Stereodefined and polyunsaturated inhibitors of histone deacetylase based on (2E,4E)-5-arylpenta-2,4-dienoic acid hydroxyamides. Bioorg Med Chem Lett. 2004 May 17;14(10):2477-81. DM6CRVS RU https://pubmed.ncbi.nlm.nih.gov/15109636 DM6CRVS DI DM6CRVS DM6CRVS DN 5-(4-Chloro-phenyl)-pentanoic acid hydroxyamide DM6CRVS MI TTSHTOI DM6CRVS MN Histone deacetylase 2 (HDAC2) DM6CRVS MT DTT DM6CRVS MA Inhibitor DM6CRVS RN Stereodefined and polyunsaturated inhibitors of histone deacetylase based on (2E,4E)-5-arylpenta-2,4-dienoic acid hydroxyamides. Bioorg Med Chem Lett. 2004 May 17;14(10):2477-81. DM6CRVS RU https://pubmed.ncbi.nlm.nih.gov/15109636 DM6CRVS DI DM6CRVS DM6CRVS DN 5-(4-Chloro-phenyl)-pentanoic acid hydroxyamide DM6CRVS MI TTTQGH8 DM6CRVS MN Histone deacetylase 4 (HDAC4) DM6CRVS MT DTT DM6CRVS MA Inhibitor DM6CRVS RN Stereodefined and polyunsaturated inhibitors of histone deacetylase based on (2E,4E)-5-arylpenta-2,4-dienoic acid hydroxyamides. Bioorg Med Chem Lett. 2004 May 17;14(10):2477-81. DM6CRVS RU https://pubmed.ncbi.nlm.nih.gov/15109636 DM6CRVS DI DM6CRVS DM6CRVS DN 5-(4-Chloro-phenyl)-pentanoic acid hydroxyamide DM6CRVS MI TT5ZKDI DM6CRVS MN Histone deacetylase 6 (HDAC6) DM6CRVS MT DTT DM6CRVS MA Inhibitor DM6CRVS RN Stereodefined and polyunsaturated inhibitors of histone deacetylase based on (2E,4E)-5-arylpenta-2,4-dienoic acid hydroxyamides. Bioorg Med Chem Lett. 2004 May 17;14(10):2477-81. DM6CRVS RU https://pubmed.ncbi.nlm.nih.gov/15109636 DM6CRVS DI DM6CRVS DM6CRVS DN 5-(4-Chloro-phenyl)-pentanoic acid hydroxyamide DM6CRVS MI TTT6LFV DM6CRVS MN Histone deacetylase 8 (HDAC8) DM6CRVS MT DTT DM6CRVS MA Inhibitor DM6CRVS RN Stereodefined and polyunsaturated inhibitors of histone deacetylase based on (2E,4E)-5-arylpenta-2,4-dienoic acid hydroxyamides. Bioorg Med Chem Lett. 2004 May 17;14(10):2477-81. DM6CRVS RU https://pubmed.ncbi.nlm.nih.gov/15109636 DMTDNX3 DI DMTDNX3 DMTDNX3 DN 5-(4'-cyanobiphenyl-4-yl)-3-hydroxypentanoic acid DMTDNX3 MI TTXZ0KQ DMTDNX3 MN Matrix metalloproteinase-12 (MMP-12) DMTDNX3 MT DTT DMTDNX3 MA Inhibitor DMTDNX3 RN The identification of beta-hydroxy carboxylic acids as selective MMP-12 inhibitors. Bioorg Med Chem Lett. 2009 Oct 1;19(19):5760-3. DMTDNX3 RU https://pubmed.ncbi.nlm.nih.gov/19703773 DMTDNX3 DI DMTDNX3 DMTDNX3 DN 5-(4'-cyanobiphenyl-4-yl)-3-hydroxypentanoic acid DMTDNX3 MI TTHY57M DMTDNX3 MN Matrix metalloproteinase-13 (MMP-13) DMTDNX3 MT DTT DMTDNX3 MA Inhibitor DMTDNX3 RN The identification of beta-hydroxy carboxylic acids as selective MMP-12 inhibitors. Bioorg Med Chem Lett. 2009 Oct 1;19(19):5760-3. DMTDNX3 RU https://pubmed.ncbi.nlm.nih.gov/19703773 DMISOLU DI DMISOLU DMISOLU DN 5-(4-hydroxy-2,6-dimethylstyryl)nicotinic acid DMISOLU MI TTAN5W2 DMISOLU MN Raf messenger RNA (Raf mRNA) DMISOLU MT DTT DMISOLU MA Inhibitor DMISOLU RN Aza-stilbenes as potent and selective c-RAF inhibitors. Bioorg Med Chem Lett. 2006 Oct 15;16(20):5378-83. DMISOLU RU https://pubmed.ncbi.nlm.nih.gov/16890436 DMB2GLE DI DMB2GLE DMB2GLE DN 5-(4-hydroxyphenyl)-1,3,4-oxadiazole-2(3H)-thione DMB2GLE MI TTULVH8 DMB2GLE MN Tyrosinase (TYR) DMB2GLE MT DTT DMB2GLE MA Inhibitor DMB2GLE RN New potent inhibitors of tyrosinase: novel clues to binding of 1,3,4-thiadiazole-2(3H)-thiones, 1,3,4-oxadiazole-2(3H)-thiones, 4-amino-1,2,4-triaz... Bioorg Med Chem. 2010 Jun 1;18(11):4042-8. DMB2GLE RU https://pubmed.ncbi.nlm.nih.gov/20452224 DM7KQXL DI DM7KQXL DM7KQXL DN 5-(4-hydroxyphenyl)-3H-1,2-dithiole-3-thione DM7KQXL MI TTBH0VX DM7KQXL MN Histone deacetylase (HDAC) DM7KQXL MT DTT DM7KQXL MA Inhibitor DM7KQXL RN New sulfurated derivatives of valproic acid with enhanced histone deacetylase inhibitory activity. Bioorg Med Chem Lett. 2008 Mar 15;18(6):1893-7. DM7KQXL RU https://pubmed.ncbi.nlm.nih.gov/18294844 DM7KQXL DI DM7KQXL DM7KQXL DN 5-(4-hydroxyphenyl)-3H-1,2-dithiole-3-thione DM7KQXL MI TT6R7JZ DM7KQXL MN Histone deacetylase 1 (HDAC1) DM7KQXL MT DTT DM7KQXL MA Inhibitor DM7KQXL RN New sulfurated derivatives of valproic acid with enhanced histone deacetylase inhibitory activity. Bioorg Med Chem Lett. 2008 Mar 15;18(6):1893-7. DM7KQXL RU https://pubmed.ncbi.nlm.nih.gov/18294844 DM7KQXL DI DM7KQXL DM7KQXL DN 5-(4-hydroxyphenyl)-3H-1,2-dithiole-3-thione DM7KQXL MI TTYHPU6 DM7KQXL MN Histone deacetylase 10 (HDAC10) DM7KQXL MT DTT DM7KQXL MA Inhibitor DM7KQXL RN New sulfurated derivatives of valproic acid with enhanced histone deacetylase inhibitory activity. Bioorg Med Chem Lett. 2008 Mar 15;18(6):1893-7. DM7KQXL RU https://pubmed.ncbi.nlm.nih.gov/18294844 DM7KQXL DI DM7KQXL DM7KQXL DN 5-(4-hydroxyphenyl)-3H-1,2-dithiole-3-thione DM7KQXL MI TTSHTOI DM7KQXL MN Histone deacetylase 2 (HDAC2) DM7KQXL MT DTT DM7KQXL MA Inhibitor DM7KQXL RN New sulfurated derivatives of valproic acid with enhanced histone deacetylase inhibitory activity. Bioorg Med Chem Lett. 2008 Mar 15;18(6):1893-7. DM7KQXL RU https://pubmed.ncbi.nlm.nih.gov/18294844 DM7KQXL DI DM7KQXL DM7KQXL DN 5-(4-hydroxyphenyl)-3H-1,2-dithiole-3-thione DM7KQXL MI TTTQGH8 DM7KQXL MN Histone deacetylase 4 (HDAC4) DM7KQXL MT DTT DM7KQXL MA Inhibitor DM7KQXL RN New sulfurated derivatives of valproic acid with enhanced histone deacetylase inhibitory activity. Bioorg Med Chem Lett. 2008 Mar 15;18(6):1893-7. DM7KQXL RU https://pubmed.ncbi.nlm.nih.gov/18294844 DM7KQXL DI DM7KQXL DM7KQXL DN 5-(4-hydroxyphenyl)-3H-1,2-dithiole-3-thione DM7KQXL MI TT5ZKDI DM7KQXL MN Histone deacetylase 6 (HDAC6) DM7KQXL MT DTT DM7KQXL MA Inhibitor DM7KQXL RN New sulfurated derivatives of valproic acid with enhanced histone deacetylase inhibitory activity. Bioorg Med Chem Lett. 2008 Mar 15;18(6):1893-7. DM7KQXL RU https://pubmed.ncbi.nlm.nih.gov/18294844 DM7KQXL DI DM7KQXL DM7KQXL DN 5-(4-hydroxyphenyl)-3H-1,2-dithiole-3-thione DM7KQXL MI TTT6LFV DM7KQXL MN Histone deacetylase 8 (HDAC8) DM7KQXL MT DTT DM7KQXL MA Inhibitor DM7KQXL RN New sulfurated derivatives of valproic acid with enhanced histone deacetylase inhibitory activity. Bioorg Med Chem Lett. 2008 Mar 15;18(6):1893-7. DM7KQXL RU https://pubmed.ncbi.nlm.nih.gov/18294844 DM3SQEY DI DM3SQEY DM3SQEY DN 5-(4-Methoxyphenoxy)-2,4-Quinazolinediamine DM3SQEY MI TT9SL3Q DM3SQEY MN Polypeptide deformylase (PDF) DM3SQEY MT DTT DM3SQEY MA Inhibitor DM3SQEY RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DM3SQEY RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMCMNKA DI DMCMNKA DMCMNKA DN 5-(4-Methoxy-phenyl)-1-phenyl-1H-benzoimidazole DMCMNKA MI TTUTJGQ DMCMNKA MN Vascular endothelial growth factor receptor 2 (KDR) DMCMNKA MT DTT DMCMNKA MA Inhibitor DMCMNKA RN Design and synthesis of 1,5-diarylbenzimidazoles as inhibitors of the VEGF-receptor KDR. Bioorg Med Chem Lett. 2003 Aug 4;13(15):2485-8. DMCMNKA RU https://pubmed.ncbi.nlm.nih.gov/12852948 DMEV8WS DI DMEV8WS DMEV8WS DN 5-(4-Methoxyphenyl)-4-p-tolyl-1,2-selenazole DMEV8WS MI TT8NGED DMEV8WS MN Prostaglandin G/H synthase 1 (COX-1) DMEV8WS MT DTT DMEV8WS MA Inhibitor DMEV8WS RN Investigations concerning the COX/5-LOX inhibiting and hydroxyl radical scavenging potencies of novel 4,5-diaryl isoselenazoles. Eur J Med Chem. 2008 Jun;43(6):1152-9. DMEV8WS RU https://pubmed.ncbi.nlm.nih.gov/17976864 DMEV8WS DI DMEV8WS DMEV8WS DN 5-(4-Methoxyphenyl)-4-p-tolyl-1,2-selenazole DMEV8WS MI TTVKILB DMEV8WS MN Prostaglandin G/H synthase 2 (COX-2) DMEV8WS MT DTT DMEV8WS MA Inhibitor DMEV8WS RN Investigations concerning the COX/5-LOX inhibiting and hydroxyl radical scavenging potencies of novel 4,5-diaryl isoselenazoles. Eur J Med Chem. 2008 Jun;43(6):1152-9. DMEV8WS RU https://pubmed.ncbi.nlm.nih.gov/17976864 DMJSTCK DI DMJSTCK DMJSTCK DN 5-(4-Methoxyphenyl)-4-p-tolylisothiazole DMJSTCK MI TT8NGED DMJSTCK MN Prostaglandin G/H synthase 1 (COX-1) DMJSTCK MT DTT DMJSTCK MA Inhibitor DMJSTCK RN Diaryl-dithiolanes and -isothiazoles: COX-1/COX-2 and 5-LOX-inhibitory, *OH scavenging and anti-adhesive activities. Bioorg Med Chem. 2009 Jan 15;17(2):558-68. DMJSTCK RU https://pubmed.ncbi.nlm.nih.gov/19097798 DMNSIF2 DI DMNSIF2 DMNSIF2 DN 5-(4-Methylpiperazin-1-yl)-3-tosyl-1H-indazole DMNSIF2 MI TTJS8PY DMNSIF2 MN 5-HT 6 receptor (HTR6) DMNSIF2 MT DTT DMNSIF2 MA Inhibitor DMNSIF2 RN 5-Piperazinyl-3-sulfonylindazoles as potent and selective 5-hydroxytryptamine-6 antagonists. J Med Chem. 2010 Nov 11;53(21):7639-46. DMNSIF2 RU https://pubmed.ncbi.nlm.nih.gov/20932009 DM05OMF DI DM05OMF DM05OMF DN 5-(4-Phenoxy-phenyl)-pyrimidine-2,4,6-trione DM05OMF MI TTLM12X DM05OMF MN Matrix metalloproteinase-2 (MMP-2) DM05OMF MT DTT DM05OMF MA Inhibitor DM05OMF RN Novel 5,5-disubstitutedpyrimidine-2,4,6-triones as selective MMP inhibitors. Bioorg Med Chem Lett. 2001 Apr 23;11(8):969-72. DM05OMF RU https://pubmed.ncbi.nlm.nih.gov/11327602 DM05OMF DI DM05OMF DM05OMF DN 5-(4-Phenoxy-phenyl)-pyrimidine-2,4,6-trione DM05OMF MI TT6X50U DM05OMF MN Matrix metalloproteinase-9 (MMP-9) DM05OMF MT DTT DM05OMF MA Inhibitor DM05OMF RN Novel 5,5-disubstitutedpyrimidine-2,4,6-triones as selective MMP inhibitors. Bioorg Med Chem Lett. 2001 Apr 23;11(8):969-72. DM05OMF RU https://pubmed.ncbi.nlm.nih.gov/11327602 DM3QFCV DI DM3QFCV DM3QFCV DN 5-(4-Phenylbutoxy)psoralen DM3QFCV MI TTY3UE6 DM3QFCV MN Voltage-gated potassium channel Kv1.3 (KCNA3) DM3QFCV MT DTT DM3QFCV MA Inhibitor DM3QFCV RN Kv1.3-blocking 5-phenylalkoxypsoralens: a new class of immunomodulators. Mol Pharmacol. 2004 Jun;65(6):1364-74. DM3QFCV RU https://pubmed.ncbi.nlm.nih.gov/15155830 DMZ7K5G DI DMZ7K5G DMZ7K5G DN 5-(4-piperidyl)-4-propylisothiazol-3-ol DMZ7K5G MI TT1MPAY DMZ7K5G MN GABA(A) receptor alpha-1 (GABRA1) DMZ7K5G MT DTT DMZ7K5G MA Inhibitor DMZ7K5G RN Potent 4-arylalkyl-substituted 3-isothiazolol GABA(A) competitive/noncompetitive antagonists: synthesis and pharmacology. J Med Chem. 2006 Feb 23;49(4):1388-96. DMZ7K5G RU https://pubmed.ncbi.nlm.nih.gov/16480274 DMZ7K5G DI DMZ7K5G DMZ7K5G DN 5-(4-piperidyl)-4-propylisothiazol-3-ol DMZ7K5G MI TT06RH5 DMZ7K5G MN GABA(A) receptor gamma-2 (GABRG2) DMZ7K5G MT DTT DMZ7K5G MA Inhibitor DMZ7K5G RN Potent 4-arylalkyl-substituted 3-isothiazolol GABA(A) competitive/noncompetitive antagonists: synthesis and pharmacology. J Med Chem. 2006 Feb 23;49(4):1388-96. DMZ7K5G RU https://pubmed.ncbi.nlm.nih.gov/16480274 DMZ7K5G DI DMZ7K5G DMZ7K5G DN 5-(4-piperidyl)-4-propylisothiazol-3-ol DMZ7K5G MI TTNJYV2 DMZ7K5G MN Gamma-aminobutyric acid receptor (GAR) DMZ7K5G MT DTT DMZ7K5G MA Inhibitor DMZ7K5G RN Potent 4-arylalkyl-substituted 3-isothiazolol GABA(A) competitive/noncompetitive antagonists: synthesis and pharmacology. J Med Chem. 2006 Feb 23;49(4):1388-96. DMZ7K5G RU https://pubmed.ncbi.nlm.nih.gov/16480274 DMVMBG0 DI DMVMBG0 DMVMBG0 DN 5-(6,7-Dimethoxy-quinolin-3-yl)-1H-pyridin-2-one DMVMBG0 MI TT8FYO9 DMVMBG0 MN Platelet-derived growth factor receptor alpha (PDGFRA) DMVMBG0 MT DTT DMVMBG0 MA Inhibitor DMVMBG0 RN A new series of PDGF receptor tyrosine kinase inhibitors: 3-substituted quinoline derivatives. J Med Chem. 1994 Jul 8;37(14):2129-37. DMVMBG0 RU https://pubmed.ncbi.nlm.nih.gov/8035419 DMVMBG0 DI DMVMBG0 DMVMBG0 DN 5-(6,7-Dimethoxy-quinolin-3-yl)-1H-pyridin-2-one DMVMBG0 MI TTI7421 DMVMBG0 MN Platelet-derived growth factor receptor beta (PDGFRB) DMVMBG0 MT DTT DMVMBG0 MA Inhibitor DMVMBG0 RN A new series of PDGF receptor tyrosine kinase inhibitors: 3-substituted quinoline derivatives. J Med Chem. 1994 Jul 8;37(14):2129-37. DMVMBG0 RU https://pubmed.ncbi.nlm.nih.gov/8035419 DM0K7U5 DI DM0K7U5 DM0K7U5 DN 5-(6-chloro-2-hexyl-1H-indol-1-yl)-5-oxo-valeric acid DM0K7U5 MI TT7WBSV DM0K7U5 MN Oxoeicosanoid receptor 1 (OXER1) DM0K7U5 MT DTT DM0K7U5 MA Antagonist DM0K7U5 RN 5-Oxo-ETE receptor antagonists. J Med Chem. 2013 May 9;56(9):3725-32. DM0K7U5 RU https://pubmed.ncbi.nlm.nih.gov/23581530 DMIB9AX DI DMIB9AX DMIB9AX DN 5-(6-hydroxy-2-naphthyl)-1,2,3-benzenetriol DMIB9AX MI TTULVH8 DMIB9AX MN Tyrosinase (TYR) DMIB9AX MT DTT DMIB9AX MA Inhibitor DMIB9AX RN A newly synthesized, potent tyrosinase inhibitor: 5-(6-hydroxy-2-naphthyl)-1,2,3-benzenetriol. Bioorg Med Chem Lett. 2010 Aug 15;20(16):4882-4. DMIB9AX RU https://pubmed.ncbi.nlm.nih.gov/20619644 DMJWIPS DI DMJWIPS DMJWIPS DN 5-(6-hydroxy-2-naphthyl)pyridin-3-ol DMJWIPS MI TTIWB6L DMJWIPS MN Estradiol 17 beta-dehydrogenase 1 (17-beta-HSD1) DMJWIPS MT DTT DMJWIPS MA Inhibitor DMJWIPS RN Design, synthesis, and biological evaluation of (hydroxyphenyl)naphthalene and -quinoline derivatives: potent and selective nonsteroidal inhibitors... J Med Chem. 2008 Apr 10;51(7):2158-69. DMJWIPS RU https://pubmed.ncbi.nlm.nih.gov/18324762 DMJRBKO DI DMJRBKO DMJRBKO DN 5-(6-hydroxynaphthalen-2-yl)benzene-1,3-diol DMJRBKO MI TTULVH8 DMJRBKO MN Tyrosinase (TYR) DMJRBKO MT DTT DMJRBKO MA Inhibitor DMJRBKO RN Syntheses of hydroxy substituted 2-phenyl-naphthalenes as inhibitors of tyrosinase. Bioorg Med Chem Lett. 2007 Jan 15;17(2):461-4. DMJRBKO RU https://pubmed.ncbi.nlm.nih.gov/17064896 DMMPAWD DI DMMPAWD DMMPAWD DN 5-(6-Methoxynaphthalen-2-yl)pyridin-3-ol DMMPAWD MI TTIQUX7 DMMPAWD MN Steroid 11-beta-hydroxylase (CYP11B1) DMMPAWD MT DTT DMMPAWD MA Inhibitor DMMPAWD RN Overcoming undesirable CYP1A2 inhibition of pyridylnaphthalene-type aldosterone synthase inhibitors: influence of heteroaryl derivatization on pote... J Med Chem. 2008 Aug 28;51(16):5064-74. DMMPAWD RU https://pubmed.ncbi.nlm.nih.gov/18672861 DMGIO3R DI DMGIO3R DMGIO3R DN 5-(azepan-1-ylsulfonyl)indoline-2,3-dione DMGIO3R MI TTPF2QI DMGIO3R MN Caspase-3 (CASP3) DMGIO3R MT DTT DMGIO3R MA Inhibitor DMGIO3R RN Design, synthesis, and discovery of novel non-peptide inhibitor of Caspase-3 using ligand based and structure based virtual screening approach. Bioorg Med Chem. 2009 Aug 15;17(16):6040-7. DMGIO3R RU https://pubmed.ncbi.nlm.nih.gov/19631549 DMJIVLY DI DMJIVLY DMJIVLY DN 5-(azetidin-1-ylsulfonyl)indoline-2,3-dione DMJIVLY MI TTPF2QI DMJIVLY MN Caspase-3 (CASP3) DMJIVLY MT DTT DMJIVLY MA Inhibitor DMJIVLY RN Design, synthesis, and discovery of novel non-peptide inhibitor of Caspase-3 using ligand based and structure based virtual screening approach. Bioorg Med Chem. 2009 Aug 15;17(16):6040-7. DMJIVLY RU https://pubmed.ncbi.nlm.nih.gov/19631549 DMJAG7M DI DMJAG7M DMJAG7M DN 5-(biphenyl-4-yl)-3-methoxypentanoic acid DMJAG7M MI TTXZ0KQ DMJAG7M MN Matrix metalloproteinase-12 (MMP-12) DMJAG7M MT DTT DMJAG7M MA Inhibitor DMJAG7M RN The identification of beta-hydroxy carboxylic acids as selective MMP-12 inhibitors. Bioorg Med Chem Lett. 2009 Oct 1;19(19):5760-3. DMJAG7M RU https://pubmed.ncbi.nlm.nih.gov/19703773 DMQKU9H DI DMQKU9H DMQKU9H DN 5-(biphenyl-4-yl)-3-oxopentanoic acid DMQKU9H MI TTXZ0KQ DMQKU9H MN Matrix metalloproteinase-12 (MMP-12) DMQKU9H MT DTT DMQKU9H MA Inhibitor DMQKU9H RN The identification of beta-hydroxy carboxylic acids as selective MMP-12 inhibitors. Bioorg Med Chem Lett. 2009 Oct 1;19(19):5760-3. DMQKU9H RU https://pubmed.ncbi.nlm.nih.gov/19703773 DMPQSZN DI DMPQSZN DMPQSZN DN 5-(Biphenyl-4-yl)-pentanoic acid N-hydroxyamide DMPQSZN MI TTSHTOI DMPQSZN MN Histone deacetylase 2 (HDAC2) DMPQSZN MT DTT DMPQSZN MA Inhibitor DMPQSZN RN Design, synthesis, and evaluation of biphenyl-4-yl-acrylohydroxamic acid derivatives as histone deacetylase (HDAC) inhibitors. Eur J Med Chem. 2009 May;44(5):1900-12. DMPQSZN RU https://pubmed.ncbi.nlm.nih.gov/19084294 DMPFX0S DI DMPFX0S DMPFX0S DN 5-(DIMETHYLAMINO)-2-NAPHTHALENESULFONIC ACID DMPFX0S MI TTXAGYU DMPFX0S MN Tissue-type plasminogen activator (PLAT) DMPFX0S MT DTT DMPFX0S MA Inhibitor DMPFX0S RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DMPFX0S RU https://pubmed.ncbi.nlm.nih.gov/10592235 DM1IGOD DI DM1IGOD DM1IGOD DN 5(E)-(5'-Deoxyadenosin-5'-ylidene)pentanoic acid DM1IGOD MI TTE2KUJ DM1IGOD MN Adenosylhomocysteinase (AHCY) DM1IGOD MT DTT DM1IGOD MA Inhibitor DM1IGOD RN Synthesis of 5'-functionalized nucleosides: S-Adenosylhomocysteine analogues with the carbon-5' and sulfur atoms replaced by a vinyl or halovinyl u... Bioorg Med Chem. 2008 May 15;16(10):5424-33. DM1IGOD RU https://pubmed.ncbi.nlm.nih.gov/18457953 DM45VRX DI DM45VRX DM45VRX DN 5-(isopropylamino)quinolin-8-ol DM45VRX MI TTZJYKH DM45VRX MN Indoleamine 2,3-dioxygenase 1 (IDO1) DM45VRX MT DTT DM45VRX MA Inhibitor DM45VRX RN Rational design of indoleamine 2,3-dioxygenase inhibitors. J Med Chem. 2010 Feb 11;53(3):1172-89. DM45VRX RU https://pubmed.ncbi.nlm.nih.gov/20055453 DMYLIX9 DI DMYLIX9 DMYLIX9 DN 5-(methylthio)thiophene-2-carboxylic acid DMYLIX9 MI TTGX0HR DMYLIX9 MN Bacterial DNA ligase (Bact ligA) DMYLIX9 MT DTT DMYLIX9 MA Inhibitor DMYLIX9 RN Identification and validation of human DNA ligase inhibitors using computer-aided drug design. J Med Chem. 2008 Aug 14;51(15):4553-62. DMYLIX9 RU https://pubmed.ncbi.nlm.nih.gov/18630893 DM3TPMO DI DM3TPMO DM3TPMO DN 5'-(N-ethyl-N-isopropyl)amiloride DM3TPMO MI TTGSEFH DM3TPMO MN Sodium/hydrogen exchanger 1 (SLC9A1) DM3TPMO MT DTT DM3TPMO MA Inhibitor DM3TPMO RN NHE1 inhibition by amiloride- and benzoylguanidine-type compounds. Inhibitor binding loci deduced from chimeras of NHE1 homologues with endogenous ... J Biol Chem. 2007 Jul 6;282(27):19716-27. DM3TPMO RU https://pubmed.ncbi.nlm.nih.gov/17493937 DMG2VQB DI DMG2VQB DMG2VQB DN 5-(pentylthio)thiazolo[4,5-d]pyrimidin-7-ol DMG2VQB MI TT30C9G DMG2VQB MN C-X-C chemokine receptor type 2 (CXCR2) DMG2VQB MT DTT DMG2VQB MA Inhibitor DMG2VQB RN Hit-to-Lead studies: the discovery of potent, orally bioavailable thiazolopyrimidine CXCR2 receptor antagonists. Bioorg Med Chem Lett. 2006 Feb 15;16(4):960-3. DMG2VQB RU https://pubmed.ncbi.nlm.nih.gov/16297626 DMP4RO3 DI DMP4RO3 DMP4RO3 DN 5-(phenylethynyl)pyrimidine DMP4RO3 MI TTHS256 DMP4RO3 MN Metabotropic glutamate receptor 5 (mGluR5) DMP4RO3 MT DTT DMP4RO3 MA Inhibitor DMP4RO3 RN Synthesis and SAR of a mGluR5 allosteric partial antagonist lead: unexpected modulation of pharmacology with slight structural modifications to a 5... Bioorg Med Chem Lett. 2008 Jul 15;18(14):4098-101. DMP4RO3 RU https://pubmed.ncbi.nlm.nih.gov/18550372 DMT60AM DI DMT60AM DMT60AM DN 5-(piperidin-1-ylsulfonyl)indoline-2,3-dione DMT60AM MI TTPF2QI DMT60AM MN Caspase-3 (CASP3) DMT60AM MT DTT DMT60AM MA Inhibitor DMT60AM RN Design, synthesis, and discovery of novel non-peptide inhibitor of Caspase-3 using ligand based and structure based virtual screening approach. Bioorg Med Chem. 2009 Aug 15;17(16):6040-7. DMT60AM RU https://pubmed.ncbi.nlm.nih.gov/19631549 DM4XGFW DI DM4XGFW DM4XGFW DN 5-(piperidin-4-yl)isothiazol-3-ol DM4XGFW MI TT1MPAY DM4XGFW MN GABA(A) receptor alpha-1 (GABRA1) DM4XGFW MT DTT DM4XGFW MA Inhibitor DM4XGFW RN Potent 4-arylalkyl-substituted 3-isothiazolol GABA(A) competitive/noncompetitive antagonists: synthesis and pharmacology. J Med Chem. 2006 Feb 23;49(4):1388-96. DM4XGFW RU https://pubmed.ncbi.nlm.nih.gov/16480274 DM4XGFW DI DM4XGFW DM4XGFW DN 5-(piperidin-4-yl)isothiazol-3-ol DM4XGFW MI TT06RH5 DM4XGFW MN GABA(A) receptor gamma-2 (GABRG2) DM4XGFW MT DTT DM4XGFW MA Inhibitor DM4XGFW RN Potent 4-arylalkyl-substituted 3-isothiazolol GABA(A) competitive/noncompetitive antagonists: synthesis and pharmacology. J Med Chem. 2006 Feb 23;49(4):1388-96. DM4XGFW RU https://pubmed.ncbi.nlm.nih.gov/16480274 DM4XGFW DI DM4XGFW DM4XGFW DN 5-(piperidin-4-yl)isothiazol-3-ol DM4XGFW MI TTNJYV2 DM4XGFW MN Gamma-aminobutyric acid receptor (GAR) DM4XGFW MT DTT DM4XGFW MA Inhibitor DM4XGFW RN Potent 4-arylalkyl-substituted 3-isothiazolol GABA(A) competitive/noncompetitive antagonists: synthesis and pharmacology. J Med Chem. 2006 Feb 23;49(4):1388-96. DM4XGFW RU https://pubmed.ncbi.nlm.nih.gov/16480274 DM6GO2I DI DM6GO2I DM6GO2I DN 5-(piperidin-4-yl)isoxazol-3-ol DM6GO2I MI TT1MPAY DM6GO2I MN GABA(A) receptor alpha-1 (GABRA1) DM6GO2I MT DTT DM6GO2I MA Inhibitor DM6GO2I RN Potent 4-aryl- or 4-arylalkyl-substituted 3-isoxazolol GABA(A) antagonists: synthesis, pharmacology, and molecular modeling. J Med Chem. 2005 Jan 27;48(2):427-39. DM6GO2I RU https://pubmed.ncbi.nlm.nih.gov/15658856 DM6GO2I DI DM6GO2I DM6GO2I DN 5-(piperidin-4-yl)isoxazol-3-ol DM6GO2I MI TTZA1NY DM6GO2I MN GABA(A) receptor beta-2 (GABRB2) DM6GO2I MT DTT DM6GO2I MA Inhibitor DM6GO2I RN Potent 4-aryl- or 4-arylalkyl-substituted 3-isoxazolol GABA(A) antagonists: synthesis, pharmacology, and molecular modeling. J Med Chem. 2005 Jan 27;48(2):427-39. DM6GO2I RU https://pubmed.ncbi.nlm.nih.gov/15658856 DM6GO2I DI DM6GO2I DM6GO2I DN 5-(piperidin-4-yl)isoxazol-3-ol DM6GO2I MI TT06RH5 DM6GO2I MN GABA(A) receptor gamma-2 (GABRG2) DM6GO2I MT DTT DM6GO2I MA Inhibitor DM6GO2I RN Potent 4-aryl- or 4-arylalkyl-substituted 3-isoxazolol GABA(A) antagonists: synthesis, pharmacology, and molecular modeling. J Med Chem. 2005 Jan 27;48(2):427-39. DM6GO2I RU https://pubmed.ncbi.nlm.nih.gov/15658856 DM6GO2I DI DM6GO2I DM6GO2I DN 5-(piperidin-4-yl)isoxazol-3-ol DM6GO2I MI TTNJYV2 DM6GO2I MN Gamma-aminobutyric acid receptor (GAR) DM6GO2I MT DTT DM6GO2I MA Inhibitor DM6GO2I RN 4-aryl-5-(4-piperidyl)-3-isoxazolol GABAA antagonists: synthesis, pharmacology, and structure-activity relationships. J Med Chem. 2007 Apr 19;50(8):1988-92. DM6GO2I RU https://pubmed.ncbi.nlm.nih.gov/17375905 DM93MAX DI DM93MAX DM93MAX DN 5-(pyridin-4-yl)-1,3,4-oxadiazole-2(3H)-thione DM93MAX MI TTULVH8 DM93MAX MN Tyrosinase (TYR) DM93MAX MT DTT DM93MAX MA Inhibitor DM93MAX RN New potent inhibitors of tyrosinase: novel clues to binding of 1,3,4-thiadiazole-2(3H)-thiones, 1,3,4-oxadiazole-2(3H)-thiones, 4-amino-1,2,4-triaz... Bioorg Med Chem. 2010 Jun 1;18(11):4042-8. DM93MAX RU https://pubmed.ncbi.nlm.nih.gov/20452224 DMEL8XU DI DMEL8XU DMEL8XU DN 5-(pyridin-4-yl)-1,3,4-thiadiazole-2(3H)-thione DMEL8XU MI TTULVH8 DMEL8XU MN Tyrosinase (TYR) DMEL8XU MT DTT DMEL8XU MA Inhibitor DMEL8XU RN New potent inhibitors of tyrosinase: novel clues to binding of 1,3,4-thiadiazole-2(3H)-thiones, 1,3,4-oxadiazole-2(3H)-thiones, 4-amino-1,2,4-triaz... Bioorg Med Chem. 2010 Jun 1;18(11):4042-8. DMEL8XU RU https://pubmed.ncbi.nlm.nih.gov/20452224 DMJBK7F DI DMJBK7F DMJBK7F DN 5-(pyrrolidin-1-ylsulfonyl)indoline-2,3-dione DMJBK7F MI TTPF2QI DMJBK7F MN Caspase-3 (CASP3) DMJBK7F MT DTT DMJBK7F MA Inhibitor DMJBK7F RN Design, synthesis, and discovery of novel non-peptide inhibitor of Caspase-3 using ligand based and structure based virtual screening approach. Bioorg Med Chem. 2009 Aug 15;17(16):6040-7. DMJBK7F RU https://pubmed.ncbi.nlm.nih.gov/19631549 DMK3TEV DI DMK3TEV DMK3TEV DN 5-(trifluoromethoxy)-1H-indole-2,3-dione DMK3TEV MI TTMF541 DMK3TEV MN Liver carboxylesterase (CES1) DMK3TEV MT DTT DMK3TEV MA Inhibitor DMK3TEV RN Selective inhibition of carboxylesterases by isatins, indole-2,3-diones. J Med Chem. 2007 Apr 19;50(8):1876-85. DMK3TEV RU https://pubmed.ncbi.nlm.nih.gov/17378546 DMM7N6K DI DMM7N6K DMM7N6K DN 5,10-Dioxy-2-phenyl-benzo[g]pteridin-4-ylamine DMM7N6K MI TTJGNVC DMM7N6K MN Apoptosis regulator Bcl-2 (BCL-2) DMM7N6K MT DTT DMM7N6K MA Inhibitor DMM7N6K RN Discovery of small-molecule inhibitors of Bcl-2 through structure-based computer screening. J Med Chem. 2001 Dec 6;44(25):4313-24. DMM7N6K RU https://pubmed.ncbi.nlm.nih.gov/11728179 DMAQDK9 DI DMAQDK9 DMAQDK9 DN 5,10-Methylene-6-Hydrofolic Acid DMAQDK9 MI TTU6BFZ DMAQDK9 MN Candida Thymidylate synthase (Candi TMP1) DMAQDK9 MT DTT DMAQDK9 MA Inhibitor DMAQDK9 RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMAQDK9 RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMWSLTB DI DMWSLTB DMWSLTB DN 5,11-Dimethyl-6H-pyrido[4,3-b]carbazol-9-ol DMWSLTB MI TTST7KB DMWSLTB MN Fibroblast growth factor receptor 3 (FGFR3) DMWSLTB MT DTT DMWSLTB MA Inhibitor DMWSLTB RN Molecular modeling of wild-type and D816V c-Kit inhibition based on ATP-competitive binding of ellipticine derivatives to tyrosine kinases. J Med Chem. 2005 Oct 6;48(20):6194-201. DMWSLTB RU https://pubmed.ncbi.nlm.nih.gov/16190746 DMWSLTB DI DMWSLTB DMWSLTB DN 5,11-Dimethyl-6H-pyrido[4,3-b]carbazol-9-ol DMWSLTB MI TT8FYO9 DMWSLTB MN Platelet-derived growth factor receptor alpha (PDGFRA) DMWSLTB MT DTT DMWSLTB MA Inhibitor DMWSLTB RN Molecular modeling of wild-type and D816V c-Kit inhibition based on ATP-competitive binding of ellipticine derivatives to tyrosine kinases. J Med Chem. 2005 Oct 6;48(20):6194-201. DMWSLTB RU https://pubmed.ncbi.nlm.nih.gov/16190746 DMWSLTB DI DMWSLTB DMWSLTB DN 5,11-Dimethyl-6H-pyrido[4,3-b]carbazol-9-ol DMWSLTB MI TTX41N9 DMWSLTB MN Tyrosine-protein kinase Kit (KIT) DMWSLTB MT DTT DMWSLTB MA Inhibitor DMWSLTB RN Molecular modeling of wild-type and D816V c-Kit inhibition based on ATP-competitive binding of ellipticine derivatives to tyrosine kinases. J Med Chem. 2005 Oct 6;48(20):6194-201. DMWSLTB RU https://pubmed.ncbi.nlm.nih.gov/16190746 DMJRXLD DI DMJRXLD DMJRXLD DN 5,3'-Dipropyl-biphenyl-2,4'-diol DMJRXLD MI TTSJ6Q4 DMJRXLD MN LOX-5 messenger RNA (ALOX5 mRNA) DMJRXLD MT DTT DMJRXLD MA Inhibitor DMJRXLD RN Design and synthesis of ten biphenyl-neolignan derivatives and their in vitro inhibitory potency against cyclooxygenase-1/2 activity and 5-lipoxyge... Bioorg Med Chem. 2009 Jul 1;17(13):4459-65. DMJRXLD RU https://pubmed.ncbi.nlm.nih.gov/19481465 DMJRXLD DI DMJRXLD DMJRXLD DN 5,3'-Dipropyl-biphenyl-2,4'-diol DMJRXLD MI TT8NGED DMJRXLD MN Prostaglandin G/H synthase 1 (COX-1) DMJRXLD MT DTT DMJRXLD MA Inhibitor DMJRXLD RN Design and synthesis of ten biphenyl-neolignan derivatives and their in vitro inhibitory potency against cyclooxygenase-1/2 activity and 5-lipoxyge... Bioorg Med Chem. 2009 Jul 1;17(13):4459-65. DMJRXLD RU https://pubmed.ncbi.nlm.nih.gov/19481465 DMJRXLD DI DMJRXLD DMJRXLD DN 5,3'-Dipropyl-biphenyl-2,4'-diol DMJRXLD MI TTVKILB DMJRXLD MN Prostaglandin G/H synthase 2 (COX-2) DMJRXLD MT DTT DMJRXLD MA Inhibitor DMJRXLD RN Design and synthesis of ten biphenyl-neolignan derivatives and their in vitro inhibitory potency against cyclooxygenase-1/2 activity and 5-lipoxyge... Bioorg Med Chem. 2009 Jul 1;17(13):4459-65. DMJRXLD RU https://pubmed.ncbi.nlm.nih.gov/19481465 DMWL1UY DI DMWL1UY DMWL1UY DN 5,5-diethyl-2-(phenethylamino)oxazol-4(5H)-one DMWL1UY MI TTN7BL9 DMWL1UY MN Corticosteroid 11-beta-dehydrogenase 1 (HSD11B1) DMWL1UY MT DTT DMWL1UY MA Inhibitor DMWL1UY RN Oxazolones as potent inhibitors of 11beta-hydroxysteroid dehydrogenase type 1. Bioorg Med Chem Lett. 2007 Sep 1;17(17):4837-40. DMWL1UY RU https://pubmed.ncbi.nlm.nih.gov/17600707 DM28LNV DI DM28LNV DM28LNV DN 5,5-Diphenyl-2-iminohydantoin DM28LNV MI TT8JRS7 DM28LNV MN Beta-secretase (BACE) DM28LNV MT DTT DM28LNV MA Inhibitor DM28LNV RN Discovery of cyclic acylguanidines as highly potent and selective beta-site amyloid cleaving enzyme (BACE) inhibitors: Part I--inhibitor design and... J Med Chem. 2010 Feb 11;53(3):951-65. DM28LNV RU https://pubmed.ncbi.nlm.nih.gov/20043696 DMPVBC2 DI DMPVBC2 DMPVBC2 DN 5,5'-methylenebis(1,3,4-oxadiazole-2(3H)-thione) DMPVBC2 MI TTULVH8 DMPVBC2 MN Tyrosinase (TYR) DMPVBC2 MT DTT DMPVBC2 MA Inhibitor DMPVBC2 RN New potent inhibitors of tyrosinase: novel clues to binding of 1,3,4-thiadiazole-2(3H)-thiones, 1,3,4-oxadiazole-2(3H)-thiones, 4-amino-1,2,4-triaz... Bioorg Med Chem. 2010 Jun 1;18(11):4042-8. DMPVBC2 RU https://pubmed.ncbi.nlm.nih.gov/20452224 DMW13SO DI DMW13SO DMW13SO DN 5,5'-methylenebis(1,3,4-thiadiazole-2(3H)-thione) DMW13SO MI TTULVH8 DMW13SO MN Tyrosinase (TYR) DMW13SO MT DTT DMW13SO MA Inhibitor DMW13SO RN New potent inhibitors of tyrosinase: novel clues to binding of 1,3,4-thiadiazole-2(3H)-thiones, 1,3,4-oxadiazole-2(3H)-thiones, 4-amino-1,2,4-triaz... Bioorg Med Chem. 2010 Jun 1;18(11):4042-8. DMW13SO RU https://pubmed.ncbi.nlm.nih.gov/20452224 DMZ693W DI DMZ693W DMZ693W DN 5,5'-methylenebis(3,4-dibromobenzene-1,2-diol) DMZ693W MI TT58ZYW DMZ693W MN Mycobacterium Isocitrate lyase (MycB icl) DMZ693W MT DTT DMZ693W MA Inhibitor DMZ693W RN Bromophenols as Candida albicans isocitrate lyase inhibitors. Bioorg Med Chem Lett. 2010 Nov 15;20(22):6644-8. DMZ693W RU https://pubmed.ncbi.nlm.nih.gov/20888765 DMIQAO9 DI DMIQAO9 DMIQAO9 DN 5,6,7,8-tetrahydroanthracene-1,4-dione DMIQAO9 MI TTR0SWN DMIQAO9 MN M-phase inducer phosphatase 2 (MPIP2) DMIQAO9 MT DTT DMIQAO9 MA Inhibitor DMIQAO9 RN Bioactivities of simplified adociaquinone B and naphthoquinone derivatives against Cdc25B, MKP-1, and MKP-3 phosphatases. Bioorg Med Chem. 2009 Mar 15;17(6):2276-81. DMIQAO9 RU https://pubmed.ncbi.nlm.nih.gov/19028102 DMTL4S9 DI DMTL4S9 DMTL4S9 DN 5,6,7-Trichloro-1,4-dihydro-quinoxaline-2,3-dione DMTL4S9 MI TTLD29N DMTL4S9 MN Glutamate receptor ionotropic NMDA 1 (NMDAR1) DMTL4S9 MT DTT DMTL4S9 MA Inhibitor DMTL4S9 RN 1-Hydroxy-1,4-dihydroquinoxaline-2,3-diones: Novel antagonists at NMDA receptor glycine sites, Bioorg. Med. Chem. Lett. 6(4):439-440 (1996). DMTL4S9 RU http://www.sciencedirect.com/science/article/pii/0960894X96000364 DM53CLY DI DM53CLY DM53CLY DN 5,6,7-Trimethoxy-3-pyridin-4-yl-quinoline DM53CLY MI TT8FYO9 DM53CLY MN Platelet-derived growth factor receptor alpha (PDGFRA) DM53CLY MT DTT DM53CLY MA Inhibitor DM53CLY RN 5,7-Dimethoxy-3-(4-pyridinyl)quinoline is a potent and selective inhibitor of human vascular beta-type platelet-derived growth factor receptor tyro... J Med Chem. 1994 Aug 19;37(17):2627-9. DM53CLY RU https://pubmed.ncbi.nlm.nih.gov/8064792 DM53CLY DI DM53CLY DM53CLY DN 5,6,7-Trimethoxy-3-pyridin-4-yl-quinoline DM53CLY MI TTI7421 DM53CLY MN Platelet-derived growth factor receptor beta (PDGFRB) DM53CLY MT DTT DM53CLY MA Inhibitor DM53CLY RN 5,7-Dimethoxy-3-(4-pyridinyl)quinoline is a potent and selective inhibitor of human vascular beta-type platelet-derived growth factor receptor tyro... J Med Chem. 1994 Aug 19;37(17):2627-9. DM53CLY RU https://pubmed.ncbi.nlm.nih.gov/8064792 DM6VPF4 DI DM6VPF4 DM6VPF4 DN 5,6,7-Trimethyl-2-p-tolyl-chromen-4-one DM6VPF4 MI TTJFY5U DM6VPF4 MN Adenosine A3 receptor (ADORA3) DM6VPF4 MT DTT DM6VPF4 MA Inhibitor DM6VPF4 RN Interactions of flavonoids and other phytochemicals with adenosine receptors. J Med Chem. 1996 Feb 2;39(3):781-8. DM6VPF4 RU https://pubmed.ncbi.nlm.nih.gov/8576921 DMDCE1M DI DMDCE1M DMDCE1M DN 5,6,8-trichloroquinoline-4-one-3-carboxylic acid DMDCE1M MI TTER6YH DMDCE1M MN Casein kinase II alpha (CSNK2A1) DMDCE1M MT DTT DMDCE1M MA Inhibitor DMDCE1M RN Evaluation of 3-carboxy-4(1H)-quinolones as inhibitors of human protein kinase CK2. J Med Chem. 2006 Nov 2;49(22):6443-50. DMDCE1M RU https://pubmed.ncbi.nlm.nih.gov/17064064 DMNHT7Q DI DMNHT7Q DMNHT7Q DN 5,6,8-Trimethoxy-1,4-dimethylquinolin-2(1H)-one DMNHT7Q MI TTJLP0R DMNHT7Q MN Quinone reductase 2 (NQO2) DMNHT7Q MT DTT DMNHT7Q MA Inhibitor DMNHT7Q RN Synthesis of casimiroin and optimization of its quinone reductase 2 and aromatase inhibitory activities. J Med Chem. 2009 Apr 9;52(7):1873-84. DMNHT7Q RU https://pubmed.ncbi.nlm.nih.gov/19265439 DM97XZ1 DI DM97XZ1 DM97XZ1 DN 5,6,8-Trimethoxy-4-methylquinolin-2(1H)-one DM97XZ1 MI TTJLP0R DM97XZ1 MN Quinone reductase 2 (NQO2) DM97XZ1 MT DTT DM97XZ1 MA Inhibitor DM97XZ1 RN Synthesis of casimiroin and optimization of its quinone reductase 2 and aromatase inhibitory activities. J Med Chem. 2009 Apr 9;52(7):1873-84. DM97XZ1 RU https://pubmed.ncbi.nlm.nih.gov/19265439 DM6A4LM DI DM6A4LM DM6A4LM DN 5,6-Bis-p-tolylamino-isoindole-1,3-dione DM6A4LM MI TTGKNB4 DM6A4LM MN Epidermal growth factor receptor (EGFR) DM6A4LM MT DTT DM6A4LM MA Inhibitor DM6A4LM RN Dianilinophthalimides: potent and selective, ATP-competitive inhibitors of the EGF-receptor protein tyrosine kinase. J Med Chem. 1994 Apr 1;37(7):1015-27. DM6A4LM RU https://pubmed.ncbi.nlm.nih.gov/8151612 DMDE7XJ DI DMDE7XJ DMDE7XJ DN 5,6-Cyclic-Tetrahydropteridine DMDE7XJ MI TTCM4B3 DMDE7XJ MN Nitric-oxide synthase endothelial (NOS3) DMDE7XJ MT DTT DMDE7XJ MA Inhibitor DMDE7XJ RN DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Nucleic Acids Res. 2011 Jan;39(Database issue):D1035-41. DMDE7XJ RU https://pubmed.ncbi.nlm.nih.gov/21059682 DM3JB6S DI DM3JB6S DM3JB6S DN 5,6-dichloro-1-beta-D-ribofuranosylbenzimidazole DM3JB6S MI TTER6YH DM3JB6S MN Casein kinase II alpha (CSNK2A1) DM3JB6S MT DTT DM3JB6S MA Inhibitor DM3JB6S RN Structural insight into human CK2alpha in complex with the potent inhibitor ellagic acid. Bioorg Med Chem Lett. 2009 Jun 1;19(11):2920-3. DM3JB6S RU https://pubmed.ncbi.nlm.nih.gov/19414254 DMN1S35 DI DMN1S35 DMN1S35 DN 5,6-dichloro-3,4-dihydroquinazolin-2-amine DMN1S35 MI TTSQIFT DMN1S35 MN 5-HT 1A receptor (HTR1A) DMN1S35 MT DTT DMN1S35 MA Inhibitor DMN1S35 RN Cyclic guanidines as dual 5-HT5A/5-HT7 receptor ligands: structure-activity relationship elucidation. Bioorg Med Chem Lett. 2008 Jan 1;18(1):256-61. DMN1S35 RU https://pubmed.ncbi.nlm.nih.gov/17998160 DMN1S35 DI DMN1S35 DMN1S35 DN 5,6-dichloro-3,4-dihydroquinazolin-2-amine DMN1S35 MI TT6MSOK DMN1S35 MN 5-HT 1D receptor (HTR1D) DMN1S35 MT DTT DMN1S35 MA Inhibitor DMN1S35 RN Cyclic guanidines as dual 5-HT5A/5-HT7 receptor ligands: structure-activity relationship elucidation. Bioorg Med Chem Lett. 2008 Jan 1;18(1):256-61. DMN1S35 RU https://pubmed.ncbi.nlm.nih.gov/17998160 DMN1S35 DI DMN1S35 DMN1S35 DN 5,6-dichloro-3,4-dihydroquinazolin-2-amine DMN1S35 MI TTJQOD7 DMN1S35 MN 5-HT 2A receptor (HTR2A) DMN1S35 MT DTT DMN1S35 MA Inhibitor DMN1S35 RN Cyclic guanidines as dual 5-HT5A/5-HT7 receptor ligands: structure-activity relationship elucidation. Bioorg Med Chem Lett. 2008 Jan 1;18(1):256-61. DMN1S35 RU https://pubmed.ncbi.nlm.nih.gov/17998160 DMN1S35 DI DMN1S35 DMN1S35 DN 5,6-dichloro-3,4-dihydroquinazolin-2-amine DMN1S35 MI TTWJBZ5 DMN1S35 MN 5-HT 2C receptor (HTR2C) DMN1S35 MT DTT DMN1S35 MA Inhibitor DMN1S35 RN Cyclic guanidines as dual 5-HT5A/5-HT7 receptor ligands: structure-activity relationship elucidation. Bioorg Med Chem Lett. 2008 Jan 1;18(1):256-61. DMN1S35 RU https://pubmed.ncbi.nlm.nih.gov/17998160 DMN1S35 DI DMN1S35 DMN1S35 DN 5,6-dichloro-3,4-dihydroquinazolin-2-amine DMN1S35 MI TTPC4TU DMN1S35 MN 5-HT 3A receptor (HTR3A) DMN1S35 MT DTT DMN1S35 MA Inhibitor DMN1S35 RN Cyclic guanidines as dual 5-HT5A/5-HT7 receptor ligands: structure-activity relationship elucidation. Bioorg Med Chem Lett. 2008 Jan 1;18(1):256-61. DMN1S35 RU https://pubmed.ncbi.nlm.nih.gov/17998160 DMN1S35 DI DMN1S35 DMN1S35 DN 5,6-dichloro-3,4-dihydroquinazolin-2-amine DMN1S35 MI TTRUFDT DMN1S35 MN 5-HT 5A receptor (HTR5A) DMN1S35 MT DTT DMN1S35 MA Inhibitor DMN1S35 RN Cyclic guanidines as dual 5-HT5A/5-HT7 receptor ligands: structure-activity relationship elucidation. Bioorg Med Chem Lett. 2008 Jan 1;18(1):256-61. DMN1S35 RU https://pubmed.ncbi.nlm.nih.gov/17998160 DMN1S35 DI DMN1S35 DMN1S35 DN 5,6-dichloro-3,4-dihydroquinazolin-2-amine DMN1S35 MI TTJS8PY DMN1S35 MN 5-HT 6 receptor (HTR6) DMN1S35 MT DTT DMN1S35 MA Inhibitor DMN1S35 RN Cyclic guanidines as dual 5-HT5A/5-HT7 receptor ligands: structure-activity relationship elucidation. Bioorg Med Chem Lett. 2008 Jan 1;18(1):256-61. DMN1S35 RU https://pubmed.ncbi.nlm.nih.gov/17998160 DMN1S35 DI DMN1S35 DMN1S35 DN 5,6-dichloro-3,4-dihydroquinazolin-2-amine DMN1S35 MI TTO9X1H DMN1S35 MN 5-HT 7 receptor (HTR7) DMN1S35 MT DTT DMN1S35 MA Inhibitor DMN1S35 RN Cyclic guanidines as dual 5-HT5A/5-HT7 receptor ligands: structure-activity relationship elucidation. Bioorg Med Chem Lett. 2008 Jan 1;18(1):256-61. DMN1S35 RU https://pubmed.ncbi.nlm.nih.gov/17998160 DMR2OMU DI DMR2OMU DMR2OMU DN 5,6-Dichloro-N-(2-morpholinoethyl)nicotinamide DMR2OMU MI TT3WG5C DMR2OMU MN Monoamine oxidase type A (MAO-A) DMR2OMU MT DTT DMR2OMU MA Inhibitor DMR2OMU RN Design of novel nicotinamides as potent and selective monoamine oxidase a inhibitors. Bioorg Med Chem. 2010 Feb 15;18(4):1659-64. DMR2OMU RU https://pubmed.ncbi.nlm.nih.gov/20117937 DMZL87A DI DMZL87A DMZL87A DN 5,6-Dichloro-N-(3-morpholinopropyl)nicotinamide DMZL87A MI TT3WG5C DMZL87A MN Monoamine oxidase type A (MAO-A) DMZL87A MT DTT DMZL87A MA Inhibitor DMZL87A RN Design of novel nicotinamides as potent and selective monoamine oxidase a inhibitors. Bioorg Med Chem. 2010 Feb 15;18(4):1659-64. DMZL87A RU https://pubmed.ncbi.nlm.nih.gov/20117937 DM94V8D DI DM94V8D DM94V8D DN 5,6-dihydroxy-7-nitro-2,3-dihydroinden-1-one DM94V8D MI TTKWFB8 DM94V8D MN Catechol-O-methyl-transferase (COMT) DM94V8D MT DTT DM94V8D MA Inhibitor DM94V8D RN Synthesis and biological evaluation of a novel series of "ortho-nitrated" inhibitors of catechol-O-methyltransferase. J Med Chem. 2005 Dec 15;48(25):8070-8. DM94V8D RU https://pubmed.ncbi.nlm.nih.gov/16335931 DM07HYA DI DM07HYA DM07HYA DN 5,6-dinitroacenaphthoquinone DM07HYA MI TT1RS9F DM07HYA MN Acetylcholinesterase (AChE) DM07HYA MT DTT DM07HYA MA Inhibitor DM07HYA RN Planarity and constraint of the carbonyl groups in 1,2-diones are determinants for selective inhibition of human carboxylesterase 1. J Med Chem. 2007 Nov 15;50(23):5727-34. DM07HYA RU https://pubmed.ncbi.nlm.nih.gov/17941623 DM07HYA DI DM07HYA DM07HYA DN 5,6-dinitroacenaphthoquinone DM07HYA MI TTEB0GD DM07HYA MN Cholinesterase (BCHE) DM07HYA MT DTT DM07HYA MA Inhibitor DM07HYA RN Planarity and constraint of the carbonyl groups in 1,2-diones are determinants for selective inhibition of human carboxylesterase 1. J Med Chem. 2007 Nov 15;50(23):5727-34. DM07HYA RU https://pubmed.ncbi.nlm.nih.gov/17941623 DM07HYA DI DM07HYA DM07HYA DN 5,6-dinitroacenaphthoquinone DM07HYA MI TTMF541 DM07HYA MN Liver carboxylesterase (CES1) DM07HYA MT DTT DM07HYA MA Inhibitor DM07HYA RN Planarity and constraint of the carbonyl groups in 1,2-diones are determinants for selective inhibition of human carboxylesterase 1. J Med Chem. 2007 Nov 15;50(23):5727-34. DM07HYA RU https://pubmed.ncbi.nlm.nih.gov/17941623 DMXTYCU DI DMXTYCU DMXTYCU DN 5,6-epoxyeicosatrienoic acid DMXTYCU MI TTKP2SU DMXTYCU MN Transient receptor potential cation channel V4 (TRPV4) DMXTYCU MT DTT DMXTYCU MA Activator DMXTYCU RN Anandamide and arachidonic acid use epoxyeicosatrienoic acids to activate TRPV4 channels. Nature. 2003 Jul 24;424(6947):434-8. DMXTYCU RU https://pubmed.ncbi.nlm.nih.gov/12879072 DMA50BQ DI DMA50BQ DMA50BQ DN 5,7-Dibromo-1,4-dihydro-quinoxaline-2,3-dione DMA50BQ MI TTLD29N DMA50BQ MN Glutamate receptor ionotropic NMDA 1 (NMDAR1) DMA50BQ MT DTT DMA50BQ MA Inhibitor DMA50BQ RN 1-Hydroxy-1,4-dihydroquinoxaline-2,3-diones: Novel antagonists at NMDA receptor glycine sites, Bioorg. Med. Chem. Lett. 6(4):439-440 (1996). DMA50BQ RU http://www.sciencedirect.com/science/article/pii/0960894X96000364 DMZLOVB DI DMZLOVB DMZLOVB DN 5,7-dibromo-9H-pyrido[3,4-b]indol-6-ol DMZLOVB MI TTK25J1 DMZLOVB MN Adenosine A1 receptor (ADORA1) DMZLOVB MT DTT DMZLOVB MA Inhibitor DMZLOVB RN Synthesis of eudistomin D analogues and its effects on adenosine receptors. Bioorg Med Chem. 2008 Apr 1;16(7):3825-30. DMZLOVB RU https://pubmed.ncbi.nlm.nih.gov/18262425 DMZLOVB DI DMZLOVB DMZLOVB DN 5,7-dibromo-9H-pyrido[3,4-b]indol-6-ol DMZLOVB MI TTM2AOE DMZLOVB MN Adenosine A2a receptor (ADORA2A) DMZLOVB MT DTT DMZLOVB MA Inhibitor DMZLOVB RN Synthesis of eudistomin D analogues and its effects on adenosine receptors. Bioorg Med Chem. 2008 Apr 1;16(7):3825-30. DMZLOVB RU https://pubmed.ncbi.nlm.nih.gov/18262425 DMZLOVB DI DMZLOVB DMZLOVB DN 5,7-dibromo-9H-pyrido[3,4-b]indol-6-ol DMZLOVB MI TTJFY5U DMZLOVB MN Adenosine A3 receptor (ADORA3) DMZLOVB MT DTT DMZLOVB MA Inhibitor DMZLOVB RN Synthesis of eudistomin D analogues and its effects on adenosine receptors. Bioorg Med Chem. 2008 Apr 1;16(7):3825-30. DMZLOVB RU https://pubmed.ncbi.nlm.nih.gov/18262425 DMOJ5LM DI DMOJ5LM DMOJ5LM DN 5,7-Dichloro-1,4-dihydro-quinoxaline-2,3-dione DMOJ5LM MI TTLD29N DMOJ5LM MN Glutamate receptor ionotropic NMDA 1 (NMDAR1) DMOJ5LM MT DTT DMOJ5LM MA Inhibitor DMOJ5LM RN 1-Hydroxy-1,4-dihydroquinoxaline-2,3-diones: Novel antagonists at NMDA receptor glycine sites, Bioorg. Med. Chem. Lett. 6(4):439-440 (1996). DMOJ5LM RU http://www.sciencedirect.com/science/article/pii/0960894X96000364 DMFHDWG DI DMFHDWG DMFHDWG DN 5,7-dichloro-1H-indole-2,3-dione DMFHDWG MI TTMF541 DMFHDWG MN Liver carboxylesterase (CES1) DMFHDWG MT DTT DMFHDWG MA Inhibitor DMFHDWG RN Selective inhibition of carboxylesterases by isatins, indole-2,3-diones. J Med Chem. 2007 Apr 19;50(8):1876-85. DMFHDWG RU https://pubmed.ncbi.nlm.nih.gov/17378546 DMUADN4 DI DMUADN4 DMUADN4 DN 5,7-Dichloro-3-hydroxy-1H-quinazoline-2,4-dione DMUADN4 MI TTLD29N DMUADN4 MN Glutamate receptor ionotropic NMDA 1 (NMDAR1) DMUADN4 MT DTT DMUADN4 MA Inhibitor DMUADN4 RN 3-hydroxy-quinazoline-2,4-dione as a useful scaffold to obtain selective Gly/NMDA and AMPA receptor antagonists. Bioorg Med Chem Lett. 2004 May 3;14(9):2345-9. DMUADN4 RU https://pubmed.ncbi.nlm.nih.gov/15081038 DMUADN4 DI DMUADN4 DMUADN4 DN 5,7-Dichloro-3-hydroxy-1H-quinazoline-2,4-dione DMUADN4 MI TTKJEMQ DMUADN4 MN Glutamate receptor ionotropic NMDA 2A (NMDAR2A) DMUADN4 MT DTT DMUADN4 MA Inhibitor DMUADN4 RN 3-hydroxy-quinazoline-2,4-dione as a useful scaffold to obtain selective Gly/NMDA and AMPA receptor antagonists. Bioorg Med Chem Lett. 2004 May 3;14(9):2345-9. DMUADN4 RU https://pubmed.ncbi.nlm.nih.gov/15081038 DMUADN4 DI DMUADN4 DMUADN4 DN 5,7-Dichloro-3-hydroxy-1H-quinazoline-2,4-dione DMUADN4 MI TTN9D8E DMUADN4 MN Glutamate receptor ionotropic NMDA 2B (NMDAR2B) DMUADN4 MT DTT DMUADN4 MA Inhibitor DMUADN4 RN 3-hydroxy-quinazoline-2,4-dione as a useful scaffold to obtain selective Gly/NMDA and AMPA receptor antagonists. Bioorg Med Chem Lett. 2004 May 3;14(9):2345-9. DMUADN4 RU https://pubmed.ncbi.nlm.nih.gov/15081038 DMZJKIU DI DMZJKIU DMZJKIU DN 5,7-Dichloro-4-hydroxy-3-phenyl-1H-quinolin-2-one DMZJKIU MI TTLD29N DMZJKIU MN Glutamate receptor ionotropic NMDA 1 (NMDAR1) DMZJKIU MT DTT DMZJKIU MA Inhibitor DMZJKIU RN Amino acid bioisosteres: design of 2-quinolone derivatives as glycine-site N-methyl-D-aspartate receptor antagonists, Bioorg. Med. Chem. Lett. 3(2):299-304 (1993). DMZJKIU RU http://www.sciencedirect.com/science/article/pii/S0960894X01808970 DMZJKIU DI DMZJKIU DMZJKIU DN 5,7-Dichloro-4-hydroxy-3-phenyl-1H-quinolin-2-one DMZJKIU MI TTKJEMQ DMZJKIU MN Glutamate receptor ionotropic NMDA 2A (NMDAR2A) DMZJKIU MT DTT DMZJKIU MA Inhibitor DMZJKIU RN Amino acid bioisosteres: design of 2-quinolone derivatives as glycine-site N-methyl-D-aspartate receptor antagonists, Bioorg. Med. Chem. Lett. 3(2):299-304 (1993). DMZJKIU RU http://www.sciencedirect.com/science/article/pii/S0960894X01808970 DMZJKIU DI DMZJKIU DMZJKIU DN 5,7-Dichloro-4-hydroxy-3-phenyl-1H-quinolin-2-one DMZJKIU MI TTN9D8E DMZJKIU MN Glutamate receptor ionotropic NMDA 2B (NMDAR2B) DMZJKIU MT DTT DMZJKIU MA Inhibitor DMZJKIU RN Amino acid bioisosteres: design of 2-quinolone derivatives as glycine-site N-methyl-D-aspartate receptor antagonists, Bioorg. Med. Chem. Lett. 3(2):299-304 (1993). DMZJKIU RU http://www.sciencedirect.com/science/article/pii/S0960894X01808970 DMHKQ1L DI DMHKQ1L DMHKQ1L DN 5,7-Dichlorokynurenic Acid DMHKQ1L MI TTLD29N DMHKQ1L MN Glutamate receptor ionotropic NMDA 1 (NMDAR1) DMHKQ1L MT DTT DMHKQ1L MA Inhibitor DMHKQ1L RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DMHKQ1L RU https://pubmed.ncbi.nlm.nih.gov/10592235 DMA61I2 DI DMA61I2 DMA61I2 DN 5,7-dihydroxy-3-phenyl-3H-quinazolin-4-one DMA61I2 MI TTOM3J0 DMA61I2 MN Estrogen receptor beta (ESR2) DMA61I2 MT DTT DMA61I2 MA Inhibitor DMA61I2 RN Synthesis and characterization of 3-arylquinazolinone and 3-arylquinazolinethione derivatives as selective estrogen receptor beta modulators. J Med Chem. 2006 Apr 20;49(8):2440-55. DMA61I2 RU https://pubmed.ncbi.nlm.nih.gov/16610787 DM724JF DI DM724JF DM724JF DN 5,7-Dimethoxy-3-pyridin-4-yl-quinoline DM724JF MI TT8FYO9 DM724JF MN Platelet-derived growth factor receptor alpha (PDGFRA) DM724JF MT DTT DM724JF MA Inhibitor DM724JF RN 5,7-Dimethoxy-3-(4-pyridinyl)quinoline is a potent and selective inhibitor of human vascular beta-type platelet-derived growth factor receptor tyro... J Med Chem. 1994 Aug 19;37(17):2627-9. DM724JF RU https://pubmed.ncbi.nlm.nih.gov/8064792 DM724JF DI DM724JF DM724JF DN 5,7-Dimethoxy-3-pyridin-4-yl-quinoline DM724JF MI TTI7421 DM724JF MN Platelet-derived growth factor receptor beta (PDGFRB) DM724JF MT DTT DM724JF MA Inhibitor DM724JF RN 5,7-Dimethoxy-3-(4-pyridinyl)quinoline is a potent and selective inhibitor of human vascular beta-type platelet-derived growth factor receptor tyro... J Med Chem. 1994 Aug 19;37(17):2627-9. DM724JF RU https://pubmed.ncbi.nlm.nih.gov/8064792 DMJAQ41 DI DMJAQ41 DMJAQ41 DN 5,7-Dimethoxy-3-thiophen-3-yl-quinoline DMJAQ41 MI TT8FYO9 DMJAQ41 MN Platelet-derived growth factor receptor alpha (PDGFRA) DMJAQ41 MT DTT DMJAQ41 MA Inhibitor DMJAQ41 RN A new series of PDGF receptor tyrosine kinase inhibitors: 3-substituted quinoline derivatives. J Med Chem. 1994 Jul 8;37(14):2129-37. DMJAQ41 RU https://pubmed.ncbi.nlm.nih.gov/8035419 DMJAQ41 DI DMJAQ41 DMJAQ41 DN 5,7-Dimethoxy-3-thiophen-3-yl-quinoline DMJAQ41 MI TTI7421 DMJAQ41 MN Platelet-derived growth factor receptor beta (PDGFRB) DMJAQ41 MT DTT DMJAQ41 MA Inhibitor DMJAQ41 RN A new series of PDGF receptor tyrosine kinase inhibitors: 3-substituted quinoline derivatives. J Med Chem. 1994 Jul 8;37(14):2129-37. DMJAQ41 RU https://pubmed.ncbi.nlm.nih.gov/8035419 DMU618S DI DMU618S DMU618S DN 5,7-Dimethyl-2-m-tolyl-1H-[1,8]naphthyridin-4-one DMU618S MI TTML2WA DMU618S MN Tubulin (TUB) DMU618S MT DTT DMU618S MA Inhibitor DMU618S RN Antitumor agents. 178. Synthesis and biological evaluation of substituted 2-aryl-1,8-naphthyridin-4(1H)-ones as antitumor agents that inhibit tubul... J Med Chem. 1997 Sep 12;40(19):3049-56. DMU618S RU https://pubmed.ncbi.nlm.nih.gov/9301667 DMU618S DI DMU618S DMU618S DN 5,7-Dimethyl-2-m-tolyl-1H-[1,8]naphthyridin-4-one DMU618S MI TTYFKSZ DMU618S MN Tubulin beta (TUBB) DMU618S MT DTT DMU618S MA Inhibitor DMU618S RN Antitumor agents. 178. Synthesis and biological evaluation of substituted 2-aryl-1,8-naphthyridin-4(1H)-ones as antitumor agents that inhibit tubul... J Med Chem. 1997 Sep 12;40(19):3049-56. DMU618S RU https://pubmed.ncbi.nlm.nih.gov/9301667 DM3P79O DI DM3P79O DM3P79O DN 5,7-Dimethyl-3-thiophen-3-yl-quinoline DM3P79O MI TT8FYO9 DM3P79O MN Platelet-derived growth factor receptor alpha (PDGFRA) DM3P79O MT DTT DM3P79O MA Inhibitor DM3P79O RN A new series of PDGF receptor tyrosine kinase inhibitors: 3-substituted quinoline derivatives. J Med Chem. 1994 Jul 8;37(14):2129-37. DM3P79O RU https://pubmed.ncbi.nlm.nih.gov/8035419 DM3P79O DI DM3P79O DM3P79O DN 5,7-Dimethyl-3-thiophen-3-yl-quinoline DM3P79O MI TTI7421 DM3P79O MN Platelet-derived growth factor receptor beta (PDGFRB) DM3P79O MT DTT DM3P79O MA Inhibitor DM3P79O RN A new series of PDGF receptor tyrosine kinase inhibitors: 3-substituted quinoline derivatives. J Med Chem. 1994 Jul 8;37(14):2129-37. DM3P79O RU https://pubmed.ncbi.nlm.nih.gov/8035419 DMG4UCX DI DMG4UCX DMG4UCX DN 5,7-Dinitro-1,4-dihydro-quinoxaline-2,3-dione DMG4UCX MI TTLD29N DMG4UCX MN Glutamate receptor ionotropic NMDA 1 (NMDAR1) DMG4UCX MT DTT DMG4UCX MA Inhibitor DMG4UCX RN Amino acid bioisosteres: design of 2-quinolone derivatives as glycine-site N-methyl-D-aspartate receptor antagonists, Bioorg. Med. Chem. Lett. 3(2):299-304 (1993). DMG4UCX RU http://www.sciencedirect.com/science/article/pii/S0960894X01808970 DMG4UCX DI DMG4UCX DMG4UCX DN 5,7-Dinitro-1,4-dihydro-quinoxaline-2,3-dione DMG4UCX MI TTKJEMQ DMG4UCX MN Glutamate receptor ionotropic NMDA 2A (NMDAR2A) DMG4UCX MT DTT DMG4UCX MA Inhibitor DMG4UCX RN Amino acid bioisosteres: design of 2-quinolone derivatives as glycine-site N-methyl-D-aspartate receptor antagonists, Bioorg. Med. Chem. Lett. 3(2):299-304 (1993). DMG4UCX RU http://www.sciencedirect.com/science/article/pii/S0960894X01808970 DMG4UCX DI DMG4UCX DMG4UCX DN 5,7-Dinitro-1,4-dihydro-quinoxaline-2,3-dione DMG4UCX MI TTN9D8E DMG4UCX MN Glutamate receptor ionotropic NMDA 2B (NMDAR2B) DMG4UCX MT DTT DMG4UCX MA Inhibitor DMG4UCX RN Amino acid bioisosteres: design of 2-quinolone derivatives as glycine-site N-methyl-D-aspartate receptor antagonists, Bioorg. Med. Chem. Lett. 3(2):299-304 (1993). DMG4UCX RU http://www.sciencedirect.com/science/article/pii/S0960894X01808970 DM4TIXY DI DM4TIXY DM4TIXY DN 5,7-diphenyl-3H-imidazo[4,5-b]pyridin-2-ol DM4TIXY MI TTK25J1 DM4TIXY MN Adenosine A1 receptor (ADORA1) DM4TIXY MT DTT DM4TIXY MA Inhibitor DM4TIXY RN 2,6,8-trisubstituted 1-deazapurines as adenosine receptor antagonists. J Med Chem. 2007 Feb 22;50(4):828-34. DM4TIXY RU https://pubmed.ncbi.nlm.nih.gov/17300165 DM4TIXY DI DM4TIXY DM4TIXY DN 5,7-diphenyl-3H-imidazo[4,5-b]pyridin-2-ol DM4TIXY MI TTM2AOE DM4TIXY MN Adenosine A2a receptor (ADORA2A) DM4TIXY MT DTT DM4TIXY MA Inhibitor DM4TIXY RN 2,6,8-trisubstituted 1-deazapurines as adenosine receptor antagonists. J Med Chem. 2007 Feb 22;50(4):828-34. DM4TIXY RU https://pubmed.ncbi.nlm.nih.gov/17300165 DM4TIXY DI DM4TIXY DM4TIXY DN 5,7-diphenyl-3H-imidazo[4,5-b]pyridin-2-ol DM4TIXY MI TTJFY5U DM4TIXY MN Adenosine A3 receptor (ADORA3) DM4TIXY MT DTT DM4TIXY MA Inhibitor DM4TIXY RN 2,6,8-trisubstituted 1-deazapurines as adenosine receptor antagonists. J Med Chem. 2007 Feb 22;50(4):828-34. DM4TIXY RU https://pubmed.ncbi.nlm.nih.gov/17300165 DMKXIWQ DI DMKXIWQ DMKXIWQ DN 5,7-Diphenyl-7H-pyrrolo[2,3-d]pyrimidin-4-ol DMKXIWQ MI TT6PKBN DMKXIWQ MN Proto-oncogene c-Src (SRC) DMKXIWQ MT DTT DMKXIWQ MA Inhibitor DMKXIWQ RN Substituted 5,7-diphenyl-pyrrolo[2,3d]pyrimidines: potent inhibitors of the tyrosine kinase c-Src. Bioorg Med Chem Lett. 2000 May 1;10(9):945-9. DMKXIWQ RU https://pubmed.ncbi.nlm.nih.gov/10853665 DMOCEPA DI DMOCEPA DMOCEPA DN 5,8-Dihydroxy-1,4-naphthoquinone DMOCEPA MI TT2J34L DMOCEPA MN Arachidonate 5-lipoxygenase (5-LOX) DMOCEPA MT DTT DMOCEPA MA Inhibitor DMOCEPA RN Simple analogues of anthralin: unusual specificity of structure and antiproliferative activity. J Med Chem. 1997 Nov 7;40(23):3773-80. DMOCEPA RU https://pubmed.ncbi.nlm.nih.gov/9371243 DMOCEPA DI DMOCEPA DMOCEPA DN 5,8-Dihydroxy-1,4-naphthoquinone DMOCEPA MI TTR7UJ3 DMOCEPA MN Cytoplasmic thioredoxin reductase (TXNRD1) DMOCEPA MT DTT DMOCEPA MA Inhibitor DMOCEPA RN Novel molecular targets for antimalarial chemotherapy. Int J Antimicrob Agents. 2007 Jul;30(1):4-10. DMOCEPA RU https://pubmed.ncbi.nlm.nih.gov/17339102 DMJ1IRO DI DMJ1IRO DMJ1IRO DN 5,8-dimethoxy-1,4-dimethylquinolin-2(1H)-one DMJ1IRO MI TTJLP0R DMJ1IRO MN Quinone reductase 2 (NQO2) DMJ1IRO MT DTT DMJ1IRO MA Inhibitor DMJ1IRO RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DMJ1IRO RU https://pubmed.ncbi.nlm.nih.gov/10592235 DMEMBKW DI DMEMBKW DMEMBKW DN 5,8-Dimethoxy-4-methylquinolin-2(1H)-one DMEMBKW MI TTJLP0R DMEMBKW MN Quinone reductase 2 (NQO2) DMEMBKW MT DTT DMEMBKW MA Inhibitor DMEMBKW RN Synthesis of casimiroin and optimization of its quinone reductase 2 and aromatase inhibitory activities. J Med Chem. 2009 Apr 9;52(7):1873-84. DMEMBKW RU https://pubmed.ncbi.nlm.nih.gov/19265439 DM1SO62 DI DM1SO62 DM1SO62 DN 5,8-hydroxy-naphthoquinone DM1SO62 MI TT3PQ2Y DM1SO62 MN Plasmodium Dihydroorotate dehydrogenase (Malaria DHOdehase) DM1SO62 MT DTT DM1SO62 MA Inhibitor DM1SO62 RN Kinetics of inhibition of human and rat dihydroorotate dehydrogenase by atovaquone, lawsone derivatives, brequinar sodium and polyporic acid. Chem Biol Interact. 2000 Jan 3;124(1):61-76. DM1SO62 RU https://pubmed.ncbi.nlm.nih.gov/10658902 DM3MSZN DI DM3MSZN DM3MSZN DN 5,N-Dihydroxythalidomide DM3MSZN MI TTUV8G9 DM3MSZN MN Progesterone receptor (PGR) DM3MSZN MT DTT DM3MSZN MA Inhibitor DM3MSZN RN Progesterone receptor antagonists with a 3-phenylquinazoline-2,4-dione/2-phenylisoquinoline-1,3-dione skeleton. Bioorg Med Chem. 2008 Jul 15;16(14):7046-54. DM3MSZN RU https://pubmed.ncbi.nlm.nih.gov/18586498 DM23PL4 DI DM23PL4 DM23PL4 DN 5-[(1R)-1-ammonioethyl]isoxazol-3-olate DM23PL4 MI TT1MPAY DM23PL4 MN GABA(A) receptor alpha-1 (GABRA1) DM23PL4 MT DTT DM23PL4 MA Inhibitor DM23PL4 RN gamma-Aminobutyric acid agonists, antagonists, and uptake inhibitors. Design and therapeutic aspects. J Med Chem. 1981 Dec;24(12):1377-83. DM23PL4 RU https://pubmed.ncbi.nlm.nih.gov/6118436 DM23PL4 DI DM23PL4 DM23PL4 DN 5-[(1R)-1-ammonioethyl]isoxazol-3-olate DM23PL4 MI TTBMV1G DM23PL4 MN GABA(A) receptor alpha-2 (GABRA2) DM23PL4 MT DTT DM23PL4 MA Inhibitor DM23PL4 RN gamma-Aminobutyric acid agonists, antagonists, and uptake inhibitors. Design and therapeutic aspects. J Med Chem. 1981 Dec;24(12):1377-83. DM23PL4 RU https://pubmed.ncbi.nlm.nih.gov/6118436 DM23PL4 DI DM23PL4 DM23PL4 DN 5-[(1R)-1-ammonioethyl]isoxazol-3-olate DM23PL4 MI TT37EDJ DM23PL4 MN GABA(A) receptor alpha-3 (GABRA3) DM23PL4 MT DTT DM23PL4 MA Inhibitor DM23PL4 RN gamma-Aminobutyric acid agonists, antagonists, and uptake inhibitors. Design and therapeutic aspects. J Med Chem. 1981 Dec;24(12):1377-83. DM23PL4 RU https://pubmed.ncbi.nlm.nih.gov/6118436 DM23PL4 DI DM23PL4 DM23PL4 DN 5-[(1R)-1-ammonioethyl]isoxazol-3-olate DM23PL4 MI TTNZPQ1 DM23PL4 MN GABA(A) receptor alpha-5 (GABRA5) DM23PL4 MT DTT DM23PL4 MA Inhibitor DM23PL4 RN gamma-Aminobutyric acid agonists, antagonists, and uptake inhibitors. Design and therapeutic aspects. J Med Chem. 1981 Dec;24(12):1377-83. DM23PL4 RU https://pubmed.ncbi.nlm.nih.gov/6118436 DM23PL4 DI DM23PL4 DM23PL4 DN 5-[(1R)-1-ammonioethyl]isoxazol-3-olate DM23PL4 MI TTZA1NY DM23PL4 MN GABA(A) receptor beta-2 (GABRB2) DM23PL4 MT DTT DM23PL4 MA Inhibitor DM23PL4 RN gamma-Aminobutyric acid agonists, antagonists, and uptake inhibitors. Design and therapeutic aspects. J Med Chem. 1981 Dec;24(12):1377-83. DM23PL4 RU https://pubmed.ncbi.nlm.nih.gov/6118436 DM23PL4 DI DM23PL4 DM23PL4 DN 5-[(1R)-1-ammonioethyl]isoxazol-3-olate DM23PL4 MI TT06RH5 DM23PL4 MN GABA(A) receptor gamma-2 (GABRG2) DM23PL4 MT DTT DM23PL4 MA Inhibitor DM23PL4 RN gamma-Aminobutyric acid agonists, antagonists, and uptake inhibitors. Design and therapeutic aspects. J Med Chem. 1981 Dec;24(12):1377-83. DM23PL4 RU https://pubmed.ncbi.nlm.nih.gov/6118436 DM23PL4 DI DM23PL4 DM23PL4 DN 5-[(1R)-1-ammonioethyl]isoxazol-3-olate DM23PL4 MI TTNJYV2 DM23PL4 MN Gamma-aminobutyric acid receptor (GAR) DM23PL4 MT DTT DM23PL4 MA Inhibitor DM23PL4 RN gamma-Aminobutyric acid agonists, antagonists, and uptake inhibitors. Design and therapeutic aspects. J Med Chem. 1981 Dec;24(12):1377-83. DM23PL4 RU https://pubmed.ncbi.nlm.nih.gov/6118436 DMYAPLT DI DMYAPLT DMYAPLT DN 5-[(1S)-1-ammonioethyl]isoxazol-3-olate DMYAPLT MI TT1MPAY DMYAPLT MN GABA(A) receptor alpha-1 (GABRA1) DMYAPLT MT DTT DMYAPLT MA Inhibitor DMYAPLT RN gamma-Aminobutyric acid agonists, antagonists, and uptake inhibitors. Design and therapeutic aspects. J Med Chem. 1981 Dec;24(12):1377-83. DMYAPLT RU https://pubmed.ncbi.nlm.nih.gov/6118436 DMYAPLT DI DMYAPLT DMYAPLT DN 5-[(1S)-1-ammonioethyl]isoxazol-3-olate DMYAPLT MI TTBMV1G DMYAPLT MN GABA(A) receptor alpha-2 (GABRA2) DMYAPLT MT DTT DMYAPLT MA Inhibitor DMYAPLT RN gamma-Aminobutyric acid agonists, antagonists, and uptake inhibitors. Design and therapeutic aspects. J Med Chem. 1981 Dec;24(12):1377-83. DMYAPLT RU https://pubmed.ncbi.nlm.nih.gov/6118436 DMYAPLT DI DMYAPLT DMYAPLT DN 5-[(1S)-1-ammonioethyl]isoxazol-3-olate DMYAPLT MI TT37EDJ DMYAPLT MN GABA(A) receptor alpha-3 (GABRA3) DMYAPLT MT DTT DMYAPLT MA Inhibitor DMYAPLT RN gamma-Aminobutyric acid agonists, antagonists, and uptake inhibitors. Design and therapeutic aspects. J Med Chem. 1981 Dec;24(12):1377-83. DMYAPLT RU https://pubmed.ncbi.nlm.nih.gov/6118436 DMYAPLT DI DMYAPLT DMYAPLT DN 5-[(1S)-1-ammonioethyl]isoxazol-3-olate DMYAPLT MI TTNZPQ1 DMYAPLT MN GABA(A) receptor alpha-5 (GABRA5) DMYAPLT MT DTT DMYAPLT MA Inhibitor DMYAPLT RN gamma-Aminobutyric acid agonists, antagonists, and uptake inhibitors. Design and therapeutic aspects. J Med Chem. 1981 Dec;24(12):1377-83. DMYAPLT RU https://pubmed.ncbi.nlm.nih.gov/6118436 DMYAPLT DI DMYAPLT DMYAPLT DN 5-[(1S)-1-ammonioethyl]isoxazol-3-olate DMYAPLT MI TTZA1NY DMYAPLT MN GABA(A) receptor beta-2 (GABRB2) DMYAPLT MT DTT DMYAPLT MA Inhibitor DMYAPLT RN gamma-Aminobutyric acid agonists, antagonists, and uptake inhibitors. Design and therapeutic aspects. J Med Chem. 1981 Dec;24(12):1377-83. DMYAPLT RU https://pubmed.ncbi.nlm.nih.gov/6118436 DMYAPLT DI DMYAPLT DMYAPLT DN 5-[(1S)-1-ammonioethyl]isoxazol-3-olate DMYAPLT MI TT06RH5 DMYAPLT MN GABA(A) receptor gamma-2 (GABRG2) DMYAPLT MT DTT DMYAPLT MA Inhibitor DMYAPLT RN gamma-Aminobutyric acid agonists, antagonists, and uptake inhibitors. Design and therapeutic aspects. J Med Chem. 1981 Dec;24(12):1377-83. DMYAPLT RU https://pubmed.ncbi.nlm.nih.gov/6118436 DMYAPLT DI DMYAPLT DMYAPLT DN 5-[(1S)-1-ammonioethyl]isoxazol-3-olate DMYAPLT MI TTNJYV2 DMYAPLT MN Gamma-aminobutyric acid receptor (GAR) DMYAPLT MT DTT DMYAPLT MA Inhibitor DMYAPLT RN gamma-Aminobutyric acid agonists, antagonists, and uptake inhibitors. Design and therapeutic aspects. J Med Chem. 1981 Dec;24(12):1377-83. DMYAPLT RU https://pubmed.ncbi.nlm.nih.gov/6118436 DMM9GCA DI DMM9GCA DMM9GCA DN 5-[(2-methyl-4-thiazolyl)ethynyl]pyrimidine DMM9GCA MI TTHS256 DMM9GCA MN Metabotropic glutamate receptor 5 (mGluR5) DMM9GCA MT DTT DMM9GCA MA Inhibitor DMM9GCA RN Synthesis and structure-activity relationships of 3-[(2-methyl-1,3-thiazol-4-yl)ethynyl]pyridine analogues as potent, noncompetitive metabotropic g... J Med Chem. 2006 Feb 9;49(3):1080-100. DMM9GCA RU https://pubmed.ncbi.nlm.nih.gov/16451073 DMLFY2T DI DMLFY2T DMLFY2T DN 5-[2-(1H-pyrrol-1-yl)ethoxy]-1H-indole DMLFY2T MI TTXZEAJ DMLFY2T MN Leukotriene A-4 hydrolase (LTA4H) DMLFY2T MT DTT DMLFY2T MA Inhibitor DMLFY2T RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DMLFY2T RU https://pubmed.ncbi.nlm.nih.gov/10592235 DM1KO7U DI DM1KO7U DM1KO7U DN 5-[2-(4-hydroxyphenyl)ethyl]benzene-1,3-diol DM1KO7U MI TTXZEAJ DM1KO7U MN Leukotriene A-4 hydrolase (LTA4H) DM1KO7U MT DTT DM1KO7U MA Inhibitor DM1KO7U RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DM1KO7U RU https://pubmed.ncbi.nlm.nih.gov/10592235 DMW8RLN DI DMW8RLN DMW8RLN DN 5-[4-(Pyridin-4-ylmethyl)phenyl]-1H-indole DMW8RLN MI TTIQUX7 DMW8RLN MN Steroid 11-beta-hydroxylase (CYP11B1) DMW8RLN MT DTT DMW8RLN MA Inhibitor DMW8RLN RN Replacement of imidazolyl by pyridyl in biphenylmethylenes results in selective CYP17 and dual CYP17/CYP11B1 inhibitors for the treatment of prosta... J Med Chem. 2010 Aug 12;53(15):5749-58. DMW8RLN RU https://pubmed.ncbi.nlm.nih.gov/20684610 DMW8RLN DI DMW8RLN DMW8RLN DN 5-[4-(Pyridin-4-ylmethyl)phenyl]-1H-indole DMW8RLN MI TTRA5BZ DMW8RLN MN Steroid 17-alpha-monooxygenase (S17AH) DMW8RLN MT DTT DMW8RLN MA Inhibitor DMW8RLN RN Replacement of imidazolyl by pyridyl in biphenylmethylenes results in selective CYP17 and dual CYP17/CYP11B1 inhibitors for the treatment of prosta... J Med Chem. 2010 Aug 12;53(15):5749-58. DMW8RLN RU https://pubmed.ncbi.nlm.nih.gov/20684610 DMV7QU3 DI DMV7QU3 DMV7QU3 DN 5-[5-Bromo-indan-(1E)-ylidenemethyl]-1H-imidazole DMV7QU3 MI TTSZLWK DMV7QU3 MN Aromatase (CYP19A1) DMV7QU3 MT DTT DMV7QU3 MA Inhibitor DMV7QU3 RN Synthesis and evaluation of imidazolylmethylenetetrahydronaphthalenes and imidazolylmethyleneindanes: potent inhibitors of aldosterone synthase. J Med Chem. 2005 Mar 24;48(6):1796-805. DMV7QU3 RU https://pubmed.ncbi.nlm.nih.gov/15771425 DMV7QU3 DI DMV7QU3 DMV7QU3 DN 5-[5-Bromo-indan-(1E)-ylidenemethyl]-1H-imidazole DMV7QU3 MI TTIQUX7 DMV7QU3 MN Steroid 11-beta-hydroxylase (CYP11B1) DMV7QU3 MT DTT DMV7QU3 MA Inhibitor DMV7QU3 RN Synthesis and evaluation of imidazolylmethylenetetrahydronaphthalenes and imidazolylmethyleneindanes: potent inhibitors of aldosterone synthase. J Med Chem. 2005 Mar 24;48(6):1796-805. DMV7QU3 RU https://pubmed.ncbi.nlm.nih.gov/15771425 DMZICL8 DI DMZICL8 DMZICL8 DN 5-[5-Bromo-indan-(1Z)-ylidenemethyl]-1H-imidazole DMZICL8 MI TTSZLWK DMZICL8 MN Aromatase (CYP19A1) DMZICL8 MT DTT DMZICL8 MA Inhibitor DMZICL8 RN Synthesis and evaluation of imidazolylmethylenetetrahydronaphthalenes and imidazolylmethyleneindanes: potent inhibitors of aldosterone synthase. J Med Chem. 2005 Mar 24;48(6):1796-805. DMZICL8 RU https://pubmed.ncbi.nlm.nih.gov/15771425 DMZICL8 DI DMZICL8 DMZICL8 DN 5-[5-Bromo-indan-(1Z)-ylidenemethyl]-1H-imidazole DMZICL8 MI TTIQUX7 DMZICL8 MN Steroid 11-beta-hydroxylase (CYP11B1) DMZICL8 MT DTT DMZICL8 MA Inhibitor DMZICL8 RN Synthesis and evaluation of imidazolylmethylenetetrahydronaphthalenes and imidazolylmethyleneindanes: potent inhibitors of aldosterone synthase. J Med Chem. 2005 Mar 24;48(6):1796-805. DMZICL8 RU https://pubmed.ncbi.nlm.nih.gov/15771425 DM2RIHT DI DM2RIHT DM2RIHT DN 5-[5-Fluoro-indan-(1E)-ylidenemethyl]-pyrimidine DM2RIHT MI TTSZLWK DM2RIHT MN Aromatase (CYP19A1) DM2RIHT MT DTT DM2RIHT MA Inhibitor DM2RIHT RN Synthesis and evaluation of (pyridylmethylene)tetrahydronaphthalenes/-indanes and structurally modified derivatives: potent and selective inhibitor... J Med Chem. 2005 Mar 10;48(5):1563-75. DM2RIHT RU https://pubmed.ncbi.nlm.nih.gov/15743198 DM2RIHT DI DM2RIHT DM2RIHT DN 5-[5-Fluoro-indan-(1E)-ylidenemethyl]-pyrimidine DM2RIHT MI TTIQUX7 DM2RIHT MN Steroid 11-beta-hydroxylase (CYP11B1) DM2RIHT MT DTT DM2RIHT MA Inhibitor DM2RIHT RN Synthesis and evaluation of (pyridylmethylene)tetrahydronaphthalenes/-indanes and structurally modified derivatives: potent and selective inhibitor... J Med Chem. 2005 Mar 10;48(5):1563-75. DM2RIHT RU https://pubmed.ncbi.nlm.nih.gov/15743198 DM2RIHT DI DM2RIHT DM2RIHT DN 5-[5-Fluoro-indan-(1E)-ylidenemethyl]-pyrimidine DM2RIHT MI TTRA5BZ DM2RIHT MN Steroid 17-alpha-monooxygenase (S17AH) DM2RIHT MT DTT DM2RIHT MA Inhibitor DM2RIHT RN Synthesis and evaluation of (pyridylmethylene)tetrahydronaphthalenes/-indanes and structurally modified derivatives: potent and selective inhibitor... J Med Chem. 2005 Mar 10;48(5):1563-75. DM2RIHT RU https://pubmed.ncbi.nlm.nih.gov/15743198 DMQGX2Z DI DMQGX2Z DMQGX2Z DN 5-[5-Fluoro-indan-(1Z)-ylidenemethyl]-pyrimidine DMQGX2Z MI TTSZLWK DMQGX2Z MN Aromatase (CYP19A1) DMQGX2Z MT DTT DMQGX2Z MA Inhibitor DMQGX2Z RN Synthesis and evaluation of (pyridylmethylene)tetrahydronaphthalenes/-indanes and structurally modified derivatives: potent and selective inhibitor... J Med Chem. 2005 Mar 10;48(5):1563-75. DMQGX2Z RU https://pubmed.ncbi.nlm.nih.gov/15743198 DM5FA74 DI DM5FA74 DM5FA74 DN 5-[5-Methoxy-indan-(1E)-ylidenemethyl]-thiazole DM5FA74 MI TTSZLWK DM5FA74 MN Aromatase (CYP19A1) DM5FA74 MT DTT DM5FA74 MA Inhibitor DM5FA74 RN Synthesis and evaluation of (pyridylmethylene)tetrahydronaphthalenes/-indanes and structurally modified derivatives: potent and selective inhibitor... J Med Chem. 2005 Mar 10;48(5):1563-75. DM5FA74 RU https://pubmed.ncbi.nlm.nih.gov/15743198 DMPDN63 DI DMPDN63 DMPDN63 DN 5-[5-Methoxy-indan-(1Z)-ylidenemethyl]-thiazole DMPDN63 MI TTSZLWK DMPDN63 MN Aromatase (CYP19A1) DMPDN63 MT DTT DMPDN63 MA Inhibitor DMPDN63 RN Synthesis and evaluation of (pyridylmethylene)tetrahydronaphthalenes/-indanes and structurally modified derivatives: potent and selective inhibitor... J Med Chem. 2005 Mar 10;48(5):1563-75. DMPDN63 RU https://pubmed.ncbi.nlm.nih.gov/15743198 DMSZ3T6 DI DMSZ3T6 DMSZ3T6 DN 5-{8(Z),11(Z),14-pentadecatrienyl}resorcinol DMSZ3T6 MI TTULVH8 DMSZ3T6 MN Tyrosinase (TYR) DMSZ3T6 MT DTT DMSZ3T6 MA Inhibitor DMSZ3T6 RN Tyrosinase inhibitors from Anacardium occidentale fruits. J Nat Prod. 1994 Apr;57(4):545-51. DMSZ3T6 RU https://pubmed.ncbi.nlm.nih.gov/8021657 DM0EBWR DI DM0EBWR DM0EBWR DN 5-{8(Z),11(Z)-pentadecadienyl}resorcinol DM0EBWR MI TTULVH8 DM0EBWR MN Tyrosinase (TYR) DM0EBWR MT DTT DM0EBWR MA Inhibitor DM0EBWR RN Tyrosinase inhibitors from Anacardium occidentale fruits. J Nat Prod. 1994 Apr;57(4):545-51. DM0EBWR RU https://pubmed.ncbi.nlm.nih.gov/8021657 DMNRWEV DI DMNRWEV DMNRWEV DN 5-{8(Z),-pentadecenyl}resorcinol DMNRWEV MI TTULVH8 DMNRWEV MN Tyrosinase (TYR) DMNRWEV MT DTT DMNRWEV MA Inhibitor DMNRWEV RN Tyrosinase inhibitors from Anacardium occidentale fruits. J Nat Prod. 1994 Apr;57(4):545-51. DMNRWEV RU https://pubmed.ncbi.nlm.nih.gov/8021657 DMB7R95 DI DMB7R95 DMB7R95 DN 5-acrylamido-N-(3-bromophenyl)-2-hydroxybenzamide DMB7R95 MI TTGKNB4 DMB7R95 MN Epidermal growth factor receptor (EGFR) DMB7R95 MT DTT DMB7R95 MA Inhibitor DMB7R95 RN Acryloylamino-salicylanilides as EGFR PTK inhibitors. Bioorg Med Chem Lett. 2006 Jan 15;16(2):469-72. DMB7R95 RU https://pubmed.ncbi.nlm.nih.gov/16275081 DMHI7Y2 DI DMHI7Y2 DMHI7Y2 DN 5alpha-Androstan-3,17-Dione DMHI7Y2 MI TTIWB6L DMHI7Y2 MN Estradiol 17 beta-dehydrogenase 1 (17-beta-HSD1) DMHI7Y2 MT DTT DMHI7Y2 MA Inhibitor DMHI7Y2 RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMHI7Y2 RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMHI7Y2 DI DMHI7Y2 DMHI7Y2 DN 5alpha-Androstan-3,17-Dione DMHI7Y2 MI TTZT9R2 DMHI7Y2 MN Hydroxysteroid dehydrogenase 3-beta (HSD3B) DMHI7Y2 MT DTT DMHI7Y2 MA Inhibitor DMHI7Y2 RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMHI7Y2 RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMGA47N DI DMGA47N DMGA47N DN 5-Amino-[1,3,4]thiadiazole-2-thiol DMGA47N MI TTHQPL7 DMGA47N MN Carbonic anhydrase I (CA-I) DMGA47N MT DTT DMGA47N MA Inhibitor DMGA47N RN Carbonic anhydrase inhibitors. Inhibition of the cytosolic and tumor-associated carbonic anhydrase isozymes I, II, and IX with a series of 1,3,4-th... Bioorg Med Chem Lett. 2005 May 2;15(9):2347-52. DMGA47N RU https://pubmed.ncbi.nlm.nih.gov/15837323 DMGA47N DI DMGA47N DMGA47N DN 5-Amino-[1,3,4]thiadiazole-2-thiol DMGA47N MI TTANPDJ DMGA47N MN Carbonic anhydrase II (CA-II) DMGA47N MT DTT DMGA47N MA Inhibitor DMGA47N RN Carbonic anhydrase inhibitors. Inhibition of the cytosolic and tumor-associated carbonic anhydrase isozymes I, II, and IX with a series of 1,3,4-th... Bioorg Med Chem Lett. 2005 May 2;15(9):2347-52. DMGA47N RU https://pubmed.ncbi.nlm.nih.gov/15837323 DMGA47N DI DMGA47N DMGA47N DN 5-Amino-[1,3,4]thiadiazole-2-thiol DMGA47N MI TT2LVK8 DMGA47N MN Carbonic anhydrase IX (CA-IX) DMGA47N MT DTT DMGA47N MA Inhibitor DMGA47N RN Carbonic anhydrase inhibitors. Inhibition of the cytosolic and tumor-associated carbonic anhydrase isozymes I, II, and IX with a series of 1,3,4-th... Bioorg Med Chem Lett. 2005 May 2;15(9):2347-52. DMGA47N RU https://pubmed.ncbi.nlm.nih.gov/15837323 DMX37ZC DI DMX37ZC DMX37ZC DN 5-amino-2-phenyl-oxazole-4-carboxylic acid amide DMX37ZC MI TTJ3E9X DMX37ZC MN Inhibitor of nuclear factor kappa-B kinase beta (IKKB) DMX37ZC MT DTT DMX37ZC MA Inhibitor DMX37ZC RN Evolution of the thienopyridine class of inhibitors of IkappaB kinase-beta: part I: hit-to-lead strategies. J Med Chem. 2006 May 18;49(10):2898-908. DMX37ZC RU https://pubmed.ncbi.nlm.nih.gov/16686533 DM4SWJ7 DI DM4SWJ7 DM4SWJ7 DN 5-amino-2-p-tolyl-oxazole-4-carboxylic acid amide DM4SWJ7 MI TTJ3E9X DM4SWJ7 MN Inhibitor of nuclear factor kappa-B kinase beta (IKKB) DM4SWJ7 MT DTT DM4SWJ7 MA Inhibitor DM4SWJ7 RN Evolution of the thienopyridine class of inhibitors of IkappaB kinase-beta: part I: hit-to-lead strategies. J Med Chem. 2006 May 18;49(10):2898-908. DM4SWJ7 RU https://pubmed.ncbi.nlm.nih.gov/16686533 DMJKQ5I DI DMJKQ5I DMJKQ5I DN 5-amino-3-(N-methylpiperidin-4-yl)-1H-indole DMJKQ5I MI TTK8CXU DMJKQ5I MN 5-HT 1B receptor (HTR1B) DMJKQ5I MT DTT DMJKQ5I MA Inhibitor DMJKQ5I RN Designing selective, high affinity ligands of 5-HT1D receptor by covalent dimerization of 5-HT1F ligands derived from 4-fluoro-N-[3-(1-methyl-4-pip... J Med Chem. 2008 Jun 26;51(12):3609-16. DMJKQ5I RU https://pubmed.ncbi.nlm.nih.gov/18507369 DMJKQ5I DI DMJKQ5I DMJKQ5I DN 5-amino-3-(N-methylpiperidin-4-yl)-1H-indole DMJKQ5I MI TT6MSOK DMJKQ5I MN 5-HT 1D receptor (HTR1D) DMJKQ5I MT DTT DMJKQ5I MA Inhibitor DMJKQ5I RN Designing selective, high affinity ligands of 5-HT1D receptor by covalent dimerization of 5-HT1F ligands derived from 4-fluoro-N-[3-(1-methyl-4-pip... J Med Chem. 2008 Jun 26;51(12):3609-16. DMJKQ5I RU https://pubmed.ncbi.nlm.nih.gov/18507369 DMR853M DI DMR853M DMR853M DN 5-amino-3,4-dihydroisoquinolin-1(2H)-one DMR853M MI TTVDSZ0 DMR853M MN Poly [ADP-ribose] polymerase 1 (PARP1) DMR853M MT DTT DMR853M MA Inhibitor DMR853M RN Discovery and SAR of novel, potent and selective hexahydrobenzonaphthyridinone inhibitors of poly(ADP-ribose)polymerase-1 (PARP-1). Bioorg Med Chem Lett. 2010 Jan 15;20(2):448-52. DMR853M RU https://pubmed.ncbi.nlm.nih.gov/20015648 DMBF42W DI DMBF42W DMBF42W DN 5'-amino-5'-deoxy-alpha-D-thymidine DMBF42W MI TT5B8AX DMBF42W MN Mycobacterium Thymidine monophosphate kinase (MycB tmk) DMBF42W MT DTT DMBF42W MA Inhibitor DMBF42W RN Rational design of 5'-thiourea-substituted alpha-thymidine analogues as thymidine monophosphate kinase inhibitors capable of inhibiting mycobacteri... J Med Chem. 2007 Nov 1;50(22):5281-92. DMBF42W RU https://pubmed.ncbi.nlm.nih.gov/17910427 DMVPSXW DI DMVPSXW DMVPSXW DN 5-aminoisoquinolin-1(2H)-one DMVPSXW MI TTVDSZ0 DMVPSXW MN Poly [ADP-ribose] polymerase 1 (PARP1) DMVPSXW MT DTT DMVPSXW MA Inhibitor DMVPSXW RN Design, synthesis, and evaluation in vitro of quinoline-8-carboxamides, a new class of poly(adenosine-diphosphate-ribose)polymerase-1 (PARP-1) inhi... J Med Chem. 2009 Feb 12;52(3):868-77. DMVPSXW RU https://pubmed.ncbi.nlm.nih.gov/19117416 DMWDUVC DI DMWDUVC DMWDUVC DN 5-Aminomethyl-3-pyrrol-1-yl-oxazolidin-2-one DMWDUVC MI TTGP7BY DMWDUVC MN Monoamine oxidase type B (MAO-B) DMWDUVC MT DTT DMWDUVC MA Inhibitor DMWDUVC RN 3-(1H-Pyrrol-1-yl)-2-oxazolidinones as reversible, highly potent, and selective inhibitors of monoamine oxidase type A. J Med Chem. 2002 Mar 14;45(6):1180-3. DMWDUVC RU https://pubmed.ncbi.nlm.nih.gov/11881986 DMZK8V5 DI DMZK8V5 DMZK8V5 DN 5-Aminomethyl-4,5-dihydro-isoxazol-3-ol DMZK8V5 MI TTNJYV2 DMZK8V5 MN Gamma-aminobutyric acid receptor (GAR) DMZK8V5 MT DTT DMZK8V5 MA Inhibitor DMZK8V5 RN GABA agonists. Resolution, absolute stereochemistry, and enantioselectivity of (S)-(+)- and (R)-(-)-dihydromuscimol. J Med Chem. 1985 Nov;28(11):1612-7. DMZK8V5 RU https://pubmed.ncbi.nlm.nih.gov/2999396 DMTP9DB DI DMTP9DB DMTP9DB DN 5-Aminomethyl-naphthalen-2-ol DMTP9DB MI TTWG9A4 DMTP9DB MN Adrenergic receptor alpha-2A (ADRA2A) DMTP9DB MT DTT DMTP9DB MA Inhibitor DMTP9DB RN Examination of the role of the acidic hydrogen in imparting selectivity of 7-(aminosulfonyl)-1,2,3,4-tetrahydroisoquinoline (SK&F 29661) toward inh... J Med Chem. 1997 Dec 5;40(25):3997-4005. DMTP9DB RU https://pubmed.ncbi.nlm.nih.gov/9406590 DMTP9DB DI DMTP9DB DMTP9DB DN 5-Aminomethyl-naphthalen-2-ol DMTP9DB MI TTWM4TY DMTP9DB MN Adrenergic receptor alpha-2B (ADRA2B) DMTP9DB MT DTT DMTP9DB MA Inhibitor DMTP9DB RN Examination of the role of the acidic hydrogen in imparting selectivity of 7-(aminosulfonyl)-1,2,3,4-tetrahydroisoquinoline (SK&F 29661) toward inh... J Med Chem. 1997 Dec 5;40(25):3997-4005. DMTP9DB RU https://pubmed.ncbi.nlm.nih.gov/9406590 DMTP9DB DI DMTP9DB DMTP9DB DN 5-Aminomethyl-naphthalen-2-ol DMTP9DB MI TT2NUT5 DMTP9DB MN Adrenergic receptor alpha-2C (ADRA2C) DMTP9DB MT DTT DMTP9DB MA Inhibitor DMTP9DB RN Examination of the role of the acidic hydrogen in imparting selectivity of 7-(aminosulfonyl)-1,2,3,4-tetrahydroisoquinoline (SK&F 29661) toward inh... J Med Chem. 1997 Dec 5;40(25):3997-4005. DMTP9DB RU https://pubmed.ncbi.nlm.nih.gov/9406590 DMYTUNE DI DMYTUNE DMYTUNE DN 5-AMINO-NAPHTALENE-2-MONOSULFONATE DMYTUNE MI TTMY81X DMYTUNE MN Heparin-binding growth factor 1 (FGF1) DMYTUNE MT DTT DMYTUNE MA Inhibitor DMYTUNE RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DMYTUNE RU https://pubmed.ncbi.nlm.nih.gov/10592235 DMIBHP5 DI DMIBHP5 DMIBHP5 DN 5-aminoquinolin-8-ol DMIBHP5 MI TTZJYKH DMIBHP5 MN Indoleamine 2,3-dioxygenase 1 (IDO1) DMIBHP5 MT DTT DMIBHP5 MA Inhibitor DMIBHP5 RN Rational design of indoleamine 2,3-dioxygenase inhibitors. J Med Chem. 2010 Feb 11;53(3):1172-89. DMIBHP5 RU https://pubmed.ncbi.nlm.nih.gov/20055453 DMURTHE DI DMURTHE DMURTHE DN 5-Azido-6-benzyl-2-methyl-[1,8]naphthyridine DMURTHE MI TTM2AOE DMURTHE MN Adenosine A2a receptor (ADORA2A) DMURTHE MT DTT DMURTHE MA Inhibitor DMURTHE RN 1,8-Naphthyridin-4-one derivatives as new ligands of A2A adenosine receptors. Bioorg Med Chem Lett. 2005 Oct 15;15(20):4604-10. DMURTHE RU https://pubmed.ncbi.nlm.nih.gov/16099648 DM0HO6C DI DM0HO6C DM0HO6C DN 5-Azidomethyl-3-pyrrol-1-yl-oxazolidin-2-one DM0HO6C MI TT3WG5C DM0HO6C MN Monoamine oxidase type A (MAO-A) DM0HO6C MT DTT DM0HO6C MA Inhibitor DM0HO6C RN 3-(1H-Pyrrol-1-yl)-2-oxazolidinones as reversible, highly potent, and selective inhibitors of monoamine oxidase type A. J Med Chem. 2002 Mar 14;45(6):1180-3. DM0HO6C RU https://pubmed.ncbi.nlm.nih.gov/11881986 DM65WZ7 DI DM65WZ7 DM65WZ7 DN 5-benzhydryl-1,3,4-oxadiazole-2(3H)-thione DM65WZ7 MI TTULVH8 DM65WZ7 MN Tyrosinase (TYR) DM65WZ7 MT DTT DM65WZ7 MA Inhibitor DM65WZ7 RN New potent inhibitors of tyrosinase: novel clues to binding of 1,3,4-thiadiazole-2(3H)-thiones, 1,3,4-oxadiazole-2(3H)-thiones, 4-amino-1,2,4-triaz... Bioorg Med Chem. 2010 Jun 1;18(11):4042-8. DM65WZ7 RU https://pubmed.ncbi.nlm.nih.gov/20452224 DMBQ5HV DI DMBQ5HV DMBQ5HV DN 5-benzhydryl-1,3,4-thiadiazole-2(3H)-thione DMBQ5HV MI TTULVH8 DMBQ5HV MN Tyrosinase (TYR) DMBQ5HV MT DTT DMBQ5HV MA Inhibitor DMBQ5HV RN New potent inhibitors of tyrosinase: novel clues to binding of 1,3,4-thiadiazole-2(3H)-thiones, 1,3,4-oxadiazole-2(3H)-thiones, 4-amino-1,2,4-triaz... Bioorg Med Chem. 2010 Jun 1;18(11):4042-8. DMBQ5HV RU https://pubmed.ncbi.nlm.nih.gov/20452224 DM8QK2O DI DM8QK2O DM8QK2O DN 5-benzyl-1,3,4-oxadiazole-2(3H)-thione DM8QK2O MI TTULVH8 DM8QK2O MN Tyrosinase (TYR) DM8QK2O MT DTT DM8QK2O MA Inhibitor DM8QK2O RN New potent inhibitors of tyrosinase: novel clues to binding of 1,3,4-thiadiazole-2(3H)-thiones, 1,3,4-oxadiazole-2(3H)-thiones, 4-amino-1,2,4-triaz... Bioorg Med Chem. 2010 Jun 1;18(11):4042-8. DM8QK2O RU https://pubmed.ncbi.nlm.nih.gov/20452224 DMJVGUZ DI DMJVGUZ DMJVGUZ DN 5-Benzyl-1H-pyrazole-3-carboxylic acid DMJVGUZ MI TTWNV8U DMJVGUZ MN Nicotinic acid receptor (HCAR2) DMJVGUZ MT DTT DMJVGUZ MA Inhibitor DMJVGUZ RN Pyrazole derivatives as partial agonists for the nicotinic acid receptor. J Med Chem. 2003 Aug 28;46(18):3945-51. DMJVGUZ RU https://pubmed.ncbi.nlm.nih.gov/12930155 DM5MJ3I DI DM5MJ3I DM5MJ3I DN 5-benzyl-2-(2,4-dichlorophenoxy)phenol DM5MJ3I MI TTNX2CS DM5MJ3I MN Plasmodium Enoyl-ACP reductase (Malaria fabI) DM5MJ3I MT DTT DM5MJ3I MA Inhibitor DM5MJ3I RN Design and in silico screening of combinatorial library of antimalarial analogs of triclosan inhibiting Plasmodium falciparum enoyl-acyl carrier pr... Eur J Med Chem. 2009 Jul;44(7):3009-19. DM5MJ3I RU https://pubmed.ncbi.nlm.nih.gov/19217192 DMCKODQ DI DMCKODQ DMCKODQ DN 5-benzyl-6-chloropyrimidine-2,4(1H,3H)-dione DMCKODQ MI TTO0IB8 DMCKODQ MN Thymidine phosphorylase (TYMP) DMCKODQ MT DTT DMCKODQ MA Inhibitor DMCKODQ RN Discovery of 5-substituted-6-chlorouracils as efficient inhibitors of human thymidine phosphorylase. J Med Chem. 2007 Nov 29;50(24):6016-23. DMCKODQ RU https://pubmed.ncbi.nlm.nih.gov/17963370 DM8WB96 DI DM8WB96 DM8WB96 DN 5-Benzyloxy-benzo[b]thiophene-2-carboxamidine DM8WB96 MI TTFEZ5Q DM8WB96 MN Coagulation factor IX (F9) DM8WB96 MT DTT DM8WB96 MA Inhibitor DM8WB96 RN Studies of benzothiophene template as potent factor IXa (FIXa) inhibitors in thrombosis. J Med Chem. 2010 Feb 25;53(4):1465-72. DM8WB96 RU https://pubmed.ncbi.nlm.nih.gov/20121198 DMOM35G DI DMOM35G DMOM35G DN 5-Benzyloxytryptamine DMOM35G MI TTXDKTO DMOM35G MN Long transient receptor potential channel 8 (TRPM8) DMOM35G MT DTT DMOM35G MA Inhibitor DMOM35G RN 5-benzyloxytryptamine as an antagonist of TRPM8. Bioorg Med Chem Lett. 2010 Dec 1;20(23):7076-9. DMOM35G RU https://pubmed.ncbi.nlm.nih.gov/20965726 DMFAITE DI DMFAITE DMFAITE DN 5-Biphenyl-4-yl-5-ethyl-pyrimidine-2,4,6-trione DMFAITE MI TTLM12X DMFAITE MN Matrix metalloproteinase-2 (MMP-2) DMFAITE MT DTT DMFAITE MA Inhibitor DMFAITE RN Novel 5,5-disubstitutedpyrimidine-2,4,6-triones as selective MMP inhibitors. Bioorg Med Chem Lett. 2001 Apr 23;11(8):969-72. DMFAITE RU https://pubmed.ncbi.nlm.nih.gov/11327602 DMFAITE DI DMFAITE DMFAITE DN 5-Biphenyl-4-yl-5-ethyl-pyrimidine-2,4,6-trione DMFAITE MI TTUZ2L5 DMFAITE MN Matrix metalloproteinase-3 (MMP-3) DMFAITE MT DTT DMFAITE MA Inhibitor DMFAITE RN Novel 5,5-disubstitutedpyrimidine-2,4,6-triones as selective MMP inhibitors. Bioorg Med Chem Lett. 2001 Apr 23;11(8):969-72. DMFAITE RU https://pubmed.ncbi.nlm.nih.gov/11327602 DMFAITE DI DMFAITE DMFAITE DN 5-Biphenyl-4-yl-5-ethyl-pyrimidine-2,4,6-trione DMFAITE MI TT6X50U DMFAITE MN Matrix metalloproteinase-9 (MMP-9) DMFAITE MT DTT DMFAITE MA Inhibitor DMFAITE RN Novel 5,5-disubstitutedpyrimidine-2,4,6-triones as selective MMP inhibitors. Bioorg Med Chem Lett. 2001 Apr 23;11(8):969-72. DMFAITE RU https://pubmed.ncbi.nlm.nih.gov/11327602 DMI2PXO DI DMI2PXO DMI2PXO DN 5-Biphenyl-4-yl-5-hexyl-pyrimidine-2,4,6-trione DMI2PXO MI TTLM12X DMI2PXO MN Matrix metalloproteinase-2 (MMP-2) DMI2PXO MT DTT DMI2PXO MA Inhibitor DMI2PXO RN Novel 5,5-disubstitutedpyrimidine-2,4,6-triones as selective MMP inhibitors. Bioorg Med Chem Lett. 2001 Apr 23;11(8):969-72. DMI2PXO RU https://pubmed.ncbi.nlm.nih.gov/11327602 DMI2PXO DI DMI2PXO DMI2PXO DN 5-Biphenyl-4-yl-5-hexyl-pyrimidine-2,4,6-trione DMI2PXO MI TT6X50U DMI2PXO MN Matrix metalloproteinase-9 (MMP-9) DMI2PXO MT DTT DMI2PXO MA Inhibitor DMI2PXO RN Novel 5,5-disubstitutedpyrimidine-2,4,6-triones as selective MMP inhibitors. Bioorg Med Chem Lett. 2001 Apr 23;11(8):969-72. DMI2PXO RU https://pubmed.ncbi.nlm.nih.gov/11327602 DMMG9PV DI DMMG9PV DMMG9PV DN 5-Biphenyl-4-ylethynyl-pyrimidine DMMG9PV MI TTHS256 DMMG9PV MN Metabotropic glutamate receptor 5 (mGluR5) DMMG9PV MT DTT DMMG9PV MA Inhibitor DMMG9PV RN Synthesis and SAR of a mGluR5 allosteric partial antagonist lead: unexpected modulation of pharmacology with slight structural modifications to a 5... Bioorg Med Chem Lett. 2008 Jul 15;18(14):4098-101. DMMG9PV RU https://pubmed.ncbi.nlm.nih.gov/18550372 DM6W0QI DI DM6W0QI DM6W0QI DN 5-Biphenyl-4-ylmethyl-1-isobutyl-1H-tetrazole DM6W0QI MI TTMSFAW DM6W0QI MN Cannabinoid receptor 2 (CB2) DM6W0QI MT DTT DM6W0QI MA Inhibitor DM6W0QI RN New tetrazole-based selective anandamide uptake inhibitors. Bioorg Med Chem Lett. 2008 May 1;18(9):2820-4. DM6W0QI RU https://pubmed.ncbi.nlm.nih.gov/18424134 DMCPIK5 DI DMCPIK5 DMCPIK5 DN 5-Biphenyl-4-ylmethyl-2-isobutyl-2H-tetrazole DMCPIK5 MI TT6OEDT DMCPIK5 MN Cannabinoid receptor 1 (CB1) DMCPIK5 MT DTT DMCPIK5 MA Inhibitor DMCPIK5 RN New tetrazole-based selective anandamide uptake inhibitors. Bioorg Med Chem Lett. 2008 May 1;18(9):2820-4. DMCPIK5 RU https://pubmed.ncbi.nlm.nih.gov/18424134 DMCPIK5 DI DMCPIK5 DMCPIK5 DN 5-Biphenyl-4-ylmethyl-2-isobutyl-2H-tetrazole DMCPIK5 MI TTMSFAW DMCPIK5 MN Cannabinoid receptor 2 (CB2) DMCPIK5 MT DTT DMCPIK5 MA Inhibitor DMCPIK5 RN New tetrazole-based selective anandamide uptake inhibitors. Bioorg Med Chem Lett. 2008 May 1;18(9):2820-4. DMCPIK5 RU https://pubmed.ncbi.nlm.nih.gov/18424134 DM7BWG5 DI DM7BWG5 DM7BWG5 DN 5-BODMT DM7BWG5 MI TTCPG9S DM7BWG5 MN 5-HT 1E receptor (HTR1E) DM7BWG5 MT DTT DM7BWG5 MA Agonist DM7BWG5 RN Toward selective drug development for the human 5-hydroxytryptamine 1E receptor: a comparison of 5-hydroxytryptamine 1E and 1F receptor structure-affinity relationships. J Pharmacol Exp Ther. 2011 Jun;337(3):860-7. DM7BWG5 RU https://pubmed.ncbi.nlm.nih.gov/21422162 DM7BWG5 DI DM7BWG5 DM7BWG5 DN 5-BODMT DM7BWG5 MI TT0MI3F DM7BWG5 MN 5-HT 1F receptor (HTR1F) DM7BWG5 MT DTT DM7BWG5 MA Agonist DM7BWG5 RN Toward selective drug development for the human 5-hydroxytryptamine 1E receptor: a comparison of 5-hydroxytryptamine 1E and 1F receptor structure-affinity relationships. J Pharmacol Exp Ther. 2011 Jun;337(3):860-7. DM7BWG5 RU https://pubmed.ncbi.nlm.nih.gov/21422162 DMPITR9 DI DMPITR9 DMPITR9 DN 5-boronothiophene-2-carboxylic acid DMPITR9 MI TTLP6GN DMPITR9 MN Bacterial DD-carboxypeptidase (Bact vanYB) DMPITR9 MT DTT DMPITR9 MA Inhibitor DMPITR9 RN Synthesis and evaluation of 3-(dihydroxyboryl)benzoic acids as D,D-carboxypeptidase R39 inhibitors. J Med Chem. 2009 Oct 8;52(19):6097-106. DMPITR9 RU https://pubmed.ncbi.nlm.nih.gov/19731939 DM0HCG6 DI DM0HCG6 DM0HCG6 DN 5-bromo orotate DM0HCG6 MI TT09NOX DM0HCG6 MN Plasmodium Dihydroorotase (Malaria dho) DM0HCG6 MT DTT DM0HCG6 MA Inhibitor DM0HCG6 RN Antimalarial activity of orotate analogs that inhibit dihydroorotase and dihydroorotate dehydrogenase. Biochem Pharmacol. 1992 Mar 17;43(6):1295-301. DM0HCG6 RU https://pubmed.ncbi.nlm.nih.gov/1348618 DM2QPHE DI DM2QPHE DM2QPHE DN 5-bromo-1H-indazole DM2QPHE MI TTZUFI5 DM2QPHE MN Nitric-oxide synthase brain (NOS1) DM2QPHE MT DTT DM2QPHE MA Inhibitor DM2QPHE RN 4-substituted indazoles as new inhibitors of neuronal nitric oxide synthase. Bioorg Med Chem Lett. 2007 Jun 1;17(11):3177-80. DM2QPHE RU https://pubmed.ncbi.nlm.nih.gov/17395463 DM4WVSB DI DM4WVSB DM4WVSB DN 5-bromo-2-(4-chlorophenylsulfonamido)benzoic acid DM4WVSB MI TTZL0OI DM4WVSB MN Methionine aminopeptidase 2 (METAP2) DM4WVSB MT DTT DM4WVSB MA Inhibitor DM4WVSB RN Development of sulfonamide compounds as potent methionine aminopeptidase type II inhibitors with antiproliferative properties. Bioorg Med Chem Lett. 2006 Jul 1;16(13):3574-7. DM4WVSB RU https://pubmed.ncbi.nlm.nih.gov/16632353 DM2YL0T DI DM2YL0T DM2YL0T DN 5-Bromo-2-(4-hydroxy-phenyl)-quinolin-6-ol DM2YL0T MI TTZAYWL DM2YL0T MN Estrogen receptor (ESR) DM2YL0T MT DTT DM2YL0T MA Inhibitor DM2YL0T RN ERbeta ligands. Part 4: Synthesis and structure-activity relationships of a series of 2-phenylquinoline derivatives. Bioorg Med Chem Lett. 2005 Oct 15;15(20):4520-5. DM2YL0T RU https://pubmed.ncbi.nlm.nih.gov/16098741 DM2YL0T DI DM2YL0T DM2YL0T DN 5-Bromo-2-(4-hydroxy-phenyl)-quinolin-6-ol DM2YL0T MI TTOM3J0 DM2YL0T MN Estrogen receptor beta (ESR2) DM2YL0T MT DTT DM2YL0T MA Inhibitor DM2YL0T RN ERbeta ligands. Part 4: Synthesis and structure-activity relationships of a series of 2-phenylquinoline derivatives. Bioorg Med Chem Lett. 2005 Oct 15;15(20):4520-5. DM2YL0T RU https://pubmed.ncbi.nlm.nih.gov/16098741 DMMI4H3 DI DMMI4H3 DMMI4H3 DN 5-Bromo-2,3,4,9-tetrahydro-1H-beta-carboline DMMI4H3 MI TTJQOD7 DMMI4H3 MN 5-HT 2A receptor (HTR2A) DMMI4H3 MT DTT DMMI4H3 MA Inhibitor DMMI4H3 RN Binding of beta-carbolines at 5-HT(2) serotonin receptors. Bioorg Med Chem Lett. 2003 Dec 15;13(24):4421-5. DMMI4H3 RU https://pubmed.ncbi.nlm.nih.gov/14643338 DMMI4H3 DI DMMI4H3 DMMI4H3 DN 5-Bromo-2,3,4,9-tetrahydro-1H-beta-carboline DMMI4H3 MI TT3WG5C DMMI4H3 MN Monoamine oxidase type A (MAO-A) DMMI4H3 MT DTT DMMI4H3 MA Inhibitor DMMI4H3 RN Binding of beta-carbolines at imidazoline I2 receptors: a structure-affinity investigation. Bioorg Med Chem Lett. 2004 Feb 23;14(4):999-1002. DMMI4H3 RU https://pubmed.ncbi.nlm.nih.gov/15013009 DMMI4H3 DI DMMI4H3 DMMI4H3 DN 5-Bromo-2,3,4,9-tetrahydro-1H-beta-carboline DMMI4H3 MI TTGP7BY DMMI4H3 MN Monoamine oxidase type B (MAO-B) DMMI4H3 MT DTT DMMI4H3 MA Inhibitor DMMI4H3 RN Binding of beta-carbolines at imidazoline I2 receptors: a structure-affinity investigation. Bioorg Med Chem Lett. 2004 Feb 23;14(4):999-1002. DMMI4H3 RU https://pubmed.ncbi.nlm.nih.gov/15013009 DM2SEFR DI DM2SEFR DM2SEFR DN 5-Bromo-4,9-dihydro-3H-beta-carboline DM2SEFR MI TT3WG5C DM2SEFR MN Monoamine oxidase type A (MAO-A) DM2SEFR MT DTT DM2SEFR MA Inhibitor DM2SEFR RN Binding of beta-carbolines at imidazoline I2 receptors: a structure-affinity investigation. Bioorg Med Chem Lett. 2004 Feb 23;14(4):999-1002. DM2SEFR RU https://pubmed.ncbi.nlm.nih.gov/15013009 DM2SEFR DI DM2SEFR DM2SEFR DN 5-Bromo-4,9-dihydro-3H-beta-carboline DM2SEFR MI TTGP7BY DM2SEFR MN Monoamine oxidase type B (MAO-B) DM2SEFR MT DTT DM2SEFR MA Inhibitor DM2SEFR RN Binding of beta-carbolines at imidazoline I2 receptors: a structure-affinity investigation. Bioorg Med Chem Lett. 2004 Feb 23;14(4):999-1002. DM2SEFR RU https://pubmed.ncbi.nlm.nih.gov/15013009 DMRY0OL DI DMRY0OL DMRY0OL DN 5-bromo-6-(cyclopropylamino)uracil hydrochloride DMRY0OL MI TTO0IB8 DMRY0OL MN Thymidine phosphorylase (TYMP) DMRY0OL MT DTT DMRY0OL MA Inhibitor DMRY0OL RN Design and synthesis of novel 5,6-disubstituted uracil derivatives as potent inhibitors of thymidine phosphorylase. Bioorg Med Chem Lett. 2006 Mar 1;16(5):1335-7. DMRY0OL RU https://pubmed.ncbi.nlm.nih.gov/16337119 DMZJE6M DI DMZJE6M DMZJE6M DN 5-bromo-6-hydrazinouracil hydrochloride DMZJE6M MI TTO0IB8 DMZJE6M MN Thymidine phosphorylase (TYMP) DMZJE6M MT DTT DMZJE6M MA Inhibitor DMZJE6M RN Design and synthesis of novel 5,6-disubstituted uracil derivatives as potent inhibitors of thymidine phosphorylase. Bioorg Med Chem Lett. 2006 Mar 1;16(5):1335-7. DMZJE6M RU https://pubmed.ncbi.nlm.nih.gov/16337119 DM157OQ DI DM157OQ DM157OQ DN 5-Bromo-6-methoxy-9H-beta-carboline DM157OQ MI TT1F8OQ DM157OQ MN IKKA messenger RNA (IKKA mRNA) DM157OQ MT DTT DM157OQ MA Inhibitor DM157OQ RN Novel IKK inhibitors: beta-carbolines. Bioorg Med Chem Lett. 2003 Jul 21;13(14):2419-22. DM157OQ RU https://pubmed.ncbi.nlm.nih.gov/12824047 DM157OQ DI DM157OQ DM157OQ DN 5-Bromo-6-methoxy-9H-beta-carboline DM157OQ MI TTRPDBG DM157OQ MN Inhibitor of nuclear factor kappa-B kinase (IKK) DM157OQ MT DTT DM157OQ MA Inhibitor DM157OQ RN Novel IKK inhibitors: beta-carbolines. Bioorg Med Chem Lett. 2003 Jul 21;13(14):2419-22. DM157OQ RU https://pubmed.ncbi.nlm.nih.gov/12824047 DM157OQ DI DM157OQ DM157OQ DN 5-Bromo-6-methoxy-9H-beta-carboline DM157OQ MI TTJ3E9X DM157OQ MN Inhibitor of nuclear factor kappa-B kinase beta (IKKB) DM157OQ MT DTT DM157OQ MA Inhibitor DM157OQ RN Novel IKK inhibitors: beta-carbolines. Bioorg Med Chem Lett. 2003 Jul 21;13(14):2419-22. DM157OQ RU https://pubmed.ncbi.nlm.nih.gov/12824047 DMTPRIW DI DMTPRIW DMTPRIW DN 5-Bromo-6-p-tolylamino-1H-pyrimidine-2,4-dione DMTPRIW MI TT2GPK3 DMTPRIW MN DNA topoisomerase (TOP) DMTPRIW MT DTT DMTPRIW MA Inhibitor DMTPRIW RN Inhibitors of Bacillus subtilis DNA polymerase III. Influence of modifications in the pyrimidine ring of anilino- and (benzylamino)pyrimidines. J Med Chem. 1986 May;29(5):676-81. DMTPRIW RU https://pubmed.ncbi.nlm.nih.gov/3084785 DM09Y72 DI DM09Y72 DM09Y72 DN 5-Bromo-8-imidazol-1-ylmethyl-chromen-4-one DM09Y72 MI TTSZLWK DM09Y72 MN Aromatase (CYP19A1) DM09Y72 MT DTT DM09Y72 MA Inhibitor DM09Y72 RN A new class of nonsteroidal aromatase inhibitors: design and synthesis of chromone and xanthone derivatives and inhibition of the P450 enzymes aromatase and 17 alpha-hydroxylase/C17,20-lyase. J Med Chem. 2001 Mar 1;44(5):672-80. DM09Y72 RU https://pubmed.ncbi.nlm.nih.gov/11262078 DMSVCJM DI DMSVCJM DMSVCJM DN 5-Bromo-8-piperazin-1-yl-imidazo[1,2-a]pyrazine DMSVCJM MI TTNGILX DMSVCJM MN Adrenergic receptor alpha-1A (ADRA1A) DMSVCJM MT DTT DMSVCJM MA Inhibitor DMSVCJM RN Synthesis and hypoglycemic activity of substituted 8-(1-piperazinyl)imidazo[1,2-a]pyrazines. J Med Chem. 1992 Oct 16;35(21):3845-57. DMSVCJM RU https://pubmed.ncbi.nlm.nih.gov/1359141 DMSVCJM DI DMSVCJM DMSVCJM DN 5-Bromo-8-piperazin-1-yl-imidazo[1,2-a]pyrazine DMSVCJM MI TT34BHT DMSVCJM MN Adrenergic receptor alpha-1D (ADRA1D) DMSVCJM MT DTT DMSVCJM MA Inhibitor DMSVCJM RN Synthesis and hypoglycemic activity of substituted 8-(1-piperazinyl)imidazo[1,2-a]pyrazines. J Med Chem. 1992 Oct 16;35(21):3845-57. DMSVCJM RU https://pubmed.ncbi.nlm.nih.gov/1359141 DMH908V DI DMH908V DMH908V DN 5-Bromomethyl-oxazolidin-(2Z)-ylideneamine DMH908V MI TTZUFI5 DMH908V MN Nitric-oxide synthase brain (NOS1) DMH908V MT DTT DMH908V MA Inhibitor DMH908V RN 4,5-Disubstituted-1,3-oxazolidin-2-imine derivatives: a new class of orally bioavailable nitric oxide synthase inhibitor. Bioorg Med Chem Lett. 2004 Jan 19;14(2):313-6. DMH908V RU https://pubmed.ncbi.nlm.nih.gov/14698148 DMH908V DI DMH908V DMH908V DN 5-Bromomethyl-oxazolidin-(2Z)-ylideneamine DMH908V MI TTF10I9 DMH908V MN Nitric-oxide synthase inducible (NOS2) DMH908V MT DTT DMH908V MA Inhibitor DMH908V RN 4,5-Disubstituted-1,3-oxazolidin-2-imine derivatives: a new class of orally bioavailable nitric oxide synthase inhibitor. Bioorg Med Chem Lett. 2004 Jan 19;14(2):313-6. DMH908V RU https://pubmed.ncbi.nlm.nih.gov/14698148 DM37T5L DI DM37T5L DM37T5L DN 5-bromo-N-(quinolin-8-yl)thiophene-2-sulfonamide DM37T5L MI TTSXVID DM37T5L MN Nuclear factor NF-kappa-B (NFKB) DM37T5L MT DTT DM37T5L MA Inhibitor DM37T5L RN Identification of N-(quinolin-8-yl)benzenesulfonamides as agents capable of down-regulating NFkappaB activity within two separate high-throughput s... Bioorg Med Chem Lett. 2008 Jan 1;18(1):329-35. DM37T5L RU https://pubmed.ncbi.nlm.nih.gov/18024113 DMZ8X3H DI DMZ8X3H DMZ8X3H DN 5-Bromothienyldeoxyuridine DMZ8X3H MI TTP3QRF DMZ8X3H MN Thymidine kinase 1 (TK1) DMZ8X3H MT DTT DMZ8X3H MA Inhibitor DMZ8X3H RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMZ8X3H RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMEVRH4 DI DMEVRH4 DMEVRH4 DN 5BrUTP DMEVRH4 MI TTOZHQC DMEVRH4 MN P2Y purinoceptor 2 (P2RY2) DMEVRH4 MT DTT DMEVRH4 MA Agonist DMEVRH4 RN Pharmacological selectivity of the cloned human P2U-purinoceptor: potent activation by diadenosine tetraphosphate. Br J Pharmacol. 1995 Sep;116(1):1619-27. DMEVRH4 RU https://pubmed.ncbi.nlm.nih.gov/8564228 DMEVRH4 DI DMEVRH4 DMEVRH4 DN 5BrUTP DMEVRH4 MI TTNVSKA DMEVRH4 MN P2Y purinoceptor 6 (P2RY6) DMEVRH4 MT DTT DMEVRH4 MA Agonist DMEVRH4 RN Cloning, functional expression and tissue distribution of the human P2Y6 receptor. Biochem Biophys Res Commun. 1996 May 15;222(2):303-8. DMEVRH4 RU https://pubmed.ncbi.nlm.nih.gov/8670200 DMXKQFM DI DMXKQFM DMXKQFM DN 5-Butyl-1H-pyrazole-3-carboxylic acid DMXKQFM MI TTWNV8U DMXKQFM MN Nicotinic acid receptor (HCAR2) DMXKQFM MT DTT DMXKQFM MA Inhibitor DMXKQFM RN Pyrazole derivatives as partial agonists for the nicotinic acid receptor. J Med Chem. 2003 Aug 28;46(18):3945-51. DMXKQFM RU https://pubmed.ncbi.nlm.nih.gov/12930155 DMCNU6I DI DMCNU6I DMCNU6I DN 5-butyl-2-(2,4-dichlorophenoxy)phenol DMCNU6I MI TTNX2CS DMCNU6I MN Plasmodium Enoyl-ACP reductase (Malaria fabI) DMCNU6I MT DTT DMCNU6I MA Inhibitor DMCNU6I RN Design and in silico screening of combinatorial library of antimalarial analogs of triclosan inhibiting Plasmodium falciparum enoyl-acyl carrier pr... Eur J Med Chem. 2009 Jul;44(7):3009-19. DMCNU6I RU https://pubmed.ncbi.nlm.nih.gov/19217192 DMI7DSM DI DMI7DSM DMI7DSM DN 5-butyl-2-(phenylsulfonamido)benzoic acid DMI7DSM MI TTZL0OI DMI7DSM MN Methionine aminopeptidase 2 (METAP2) DMI7DSM MT DTT DMI7DSM MA Inhibitor DMI7DSM RN Development of sulfonamide compounds as potent methionine aminopeptidase type II inhibitors with antiproliferative properties. Bioorg Med Chem Lett. 2006 Jul 1;16(13):3574-7. DMI7DSM RU https://pubmed.ncbi.nlm.nih.gov/16632353 DMFKMYV DI DMFKMYV DMFKMYV DN 5-butyl-6-chloropyrimidine-2,4(1H,3H)-dione DMFKMYV MI TTO0IB8 DMFKMYV MN Thymidine phosphorylase (TYMP) DMFKMYV MT DTT DMFKMYV MA Inhibitor DMFKMYV RN Discovery of 5-substituted-6-chlorouracils as efficient inhibitors of human thymidine phosphorylase. J Med Chem. 2007 Nov 29;50(24):6016-23. DMFKMYV RU https://pubmed.ncbi.nlm.nih.gov/17963370 DM2EPFZ DI DM2EPFZ DM2EPFZ DN 5-Butyl-8-phenyl-3H-[1,2,4]triazolo[5,1-i]purine DM2EPFZ MI TTM2AOE DM2EPFZ MN Adenosine A2a receptor (ADORA2A) DM2EPFZ MT DTT DM2EPFZ MA Inhibitor DM2EPFZ RN Facile synthesis of fused 1,2,4-triazolo[1,5-c]pyrimidine derivatives as human adenosine A3 receptor ligands. Bioorg Med Chem Lett. 2004 May 17;14(10):2443-6. DM2EPFZ RU https://pubmed.ncbi.nlm.nih.gov/15109629 DM2EPFZ DI DM2EPFZ DM2EPFZ DN 5-Butyl-8-phenyl-3H-[1,2,4]triazolo[5,1-i]purine DM2EPFZ MI TTJFY5U DM2EPFZ MN Adenosine A3 receptor (ADORA3) DM2EPFZ MT DTT DM2EPFZ MA Inhibitor DM2EPFZ RN Facile synthesis of fused 1,2,4-triazolo[1,5-c]pyrimidine derivatives as human adenosine A3 receptor ligands. Bioorg Med Chem Lett. 2004 May 17;14(10):2443-6. DM2EPFZ RU https://pubmed.ncbi.nlm.nih.gov/15109629 DM0VGCX DI DM0VGCX DM0VGCX DN 5-butyl-methyl immidazole carboxylate 30 DM0VGCX MI TT8DBY3 DM0VGCX MN Angiotensin II receptor type-1 (AGTR1) DM0VGCX MT DTT DM0VGCX MA Antagonist DM0VGCX RN The discovery of new potent non-peptide Angiotensin II AT1 receptor blockers: a concise synthesis, molecular docking studies and biological evaluation of N-substituted 5-butylimidazole derivatives. Eur J Med Chem. 2012 Sep;55:358-74. DM0VGCX RU https://pubmed.ncbi.nlm.nih.gov/22889560 DM04WVH DI DM04WVH DM04WVH DN 5-Carbazol-9-yl-pentanoic acid DM04WVH MI TTHWMFZ DM04WVH MN Fatty acid-binding protein 4 (FABP4) DM04WVH MT DTT DM04WVH MA Inhibitor DM04WVH RN Discovery of inhibitors of human adipocyte fatty acid-binding protein, a potential type 2 diabetes target. Bioorg Med Chem Lett. 2004 Sep 6;14(17):4445-8. DM04WVH RU https://pubmed.ncbi.nlm.nih.gov/15357969 DM04WVH DI DM04WVH DM04WVH DN 5-Carbazol-9-yl-pentanoic acid DM04WVH MI TTNT2S6 DM04WVH MN Fatty acid-binding protein 5 (FABP5) DM04WVH MT DTT DM04WVH MA Inhibitor DM04WVH RN Discovery of inhibitors of human adipocyte fatty acid-binding protein, a potential type 2 diabetes target. Bioorg Med Chem Lett. 2004 Sep 6;14(17):4445-8. DM04WVH RU https://pubmed.ncbi.nlm.nih.gov/15357969 DMIH7W1 DI DMIH7W1 DMIH7W1 DN 5-Chloro-1-(4-chloro-benzyl)-1H-indole-2,3-dione DMIH7W1 MI TTEAID7 DMIH7W1 MN Trypanosoma Cruzipain (Trypano CYSP) DMIH7W1 MT DTT DMIH7W1 MA Inhibitor DMIH7W1 RN Synthesis and evaluation of isatins and thiosemicarbazone derivatives against cruzain, falcipain-2 and rhodesain. Bioorg Med Chem Lett. 2003 Oct 20;13(20):3527-30. DMIH7W1 RU https://pubmed.ncbi.nlm.nih.gov/14505663 DMTJNY0 DI DMTJNY0 DMTJNY0 DN 5-Chloro-1,2,3,4-tetrahydro-acridin-9-ylamine DMTJNY0 MI TT1RS9F DMTJNY0 MN Acetylcholinesterase (AChE) DMTJNY0 MT DTT DMTJNY0 MA Inhibitor DMTJNY0 RN The synthesis and in vitro acetylcholinesterase and butyrylcholinesterase inhibitory activity of tacrine (Cognex ) derivaties, Bioorg. Med. Chem. Lett. 2(8):861-864 (1992). DMTJNY0 RU http://www.sciencedirect.com/science/article/pii/S0960894X00805454 DMOCYDU DI DMOCYDU DMOCYDU DN 5-chloro-1H-indazole DMOCYDU MI TTZUFI5 DMOCYDU MN Nitric-oxide synthase brain (NOS1) DMOCYDU MT DTT DMOCYDU MA Inhibitor DMOCYDU RN 4-substituted indazoles as new inhibitors of neuronal nitric oxide synthase. Bioorg Med Chem Lett. 2007 Jun 1;17(11):3177-80. DMOCYDU RU https://pubmed.ncbi.nlm.nih.gov/17395463 DMQ350F DI DMQ350F DMQ350F DN 5-chloro-1H-indole-2,3-dione DMQ350F MI TTMF541 DMQ350F MN Liver carboxylesterase (CES1) DMQ350F MT DTT DMQ350F MA Inhibitor DMQ350F RN Selective inhibition of carboxylesterases by isatins, indole-2,3-diones. J Med Chem. 2007 Apr 19;50(8):1876-85. DMQ350F RU https://pubmed.ncbi.nlm.nih.gov/17378546 DMDZ8NA DI DMDZ8NA DMDZ8NA DN 5-chloro-2-(2-chloro-4-hydroxyphenoxy)phenol DMDZ8NA MI TTNX2CS DMDZ8NA MN Plasmodium Enoyl-ACP reductase (Malaria fabI) DMDZ8NA MT DTT DMDZ8NA MA Inhibitor DMDZ8NA RN Synthesis, biological activity, and X-ray crystal structural analysis of diaryl ether inhibitors of malarial enoyl acyl carrier protein reductase. ... Bioorg Med Chem Lett. 2005 Dec 1;15(23):5247-52. DMDZ8NA RU https://pubmed.ncbi.nlm.nih.gov/16198563 DMAJ8BS DI DMAJ8BS DMAJ8BS DN 5-chloro-2-(2-chloro-4-nitrophenoxy)phenol DMAJ8BS MI TTNX2CS DMAJ8BS MN Plasmodium Enoyl-ACP reductase (Malaria fabI) DMAJ8BS MT DTT DMAJ8BS MA Inhibitor DMAJ8BS RN Synthesis, biological activity, and X-ray crystal structural analysis of diaryl ether inhibitors of malarial enoyl acyl carrier protein reductase. ... Bioorg Med Chem Lett. 2005 Dec 1;15(23):5247-52. DMAJ8BS RU https://pubmed.ncbi.nlm.nih.gov/16198563 DMH4SLZ DI DMH4SLZ DMH4SLZ DN 5-Chloro-2-(2-methylquinolin-7-yl)benzonitrile DMH4SLZ MI TTHS256 DMH4SLZ MN Metabotropic glutamate receptor 5 (mGluR5) DMH4SLZ MT DTT DMH4SLZ MA Inhibitor DMH4SLZ RN Structure-activity relationships in a novel series of 7-substituted-aryl quinolines and 5-substituted-aryl benzothiazoles at the metabotropic gluta... Bioorg Med Chem. 2010 May 1;18(9):3026-35. DMH4SLZ RU https://pubmed.ncbi.nlm.nih.gov/20382541 DMCFIZN DI DMCFIZN DMCFIZN DN 5-Chloro-2-(4-hydroxy-phenyl)-benzooxazol-6-ol DMCFIZN MI TTZAYWL DMCFIZN MN Estrogen receptor (ESR) DMCFIZN MT DTT DMCFIZN MA Inhibitor DMCFIZN RN Design and synthesis of aryl diphenolic azoles as potent and selective estrogen receptor-beta ligands. J Med Chem. 2004 Oct 7;47(21):5021-40. DMCFIZN RU https://pubmed.ncbi.nlm.nih.gov/15456246 DMCFIZN DI DMCFIZN DMCFIZN DN 5-Chloro-2-(4-hydroxy-phenyl)-benzooxazol-6-ol DMCFIZN MI TTOM3J0 DMCFIZN MN Estrogen receptor beta (ESR2) DMCFIZN MT DTT DMCFIZN MA Inhibitor DMCFIZN RN Design and synthesis of aryl diphenolic azoles as potent and selective estrogen receptor-beta ligands. J Med Chem. 2004 Oct 7;47(21):5021-40. DMCFIZN RU https://pubmed.ncbi.nlm.nih.gov/15456246 DMXNPSB DI DMXNPSB DMXNPSB DN 5-Chloro-2-(4-hydroxy-phenyl)-quinolin-6-ol DMXNPSB MI TTZAYWL DMXNPSB MN Estrogen receptor (ESR) DMXNPSB MT DTT DMXNPSB MA Inhibitor DMXNPSB RN ERbeta ligands. Part 4: Synthesis and structure-activity relationships of a series of 2-phenylquinoline derivatives. Bioorg Med Chem Lett. 2005 Oct 15;15(20):4520-5. DMXNPSB RU https://pubmed.ncbi.nlm.nih.gov/16098741 DMXNPSB DI DMXNPSB DMXNPSB DN 5-Chloro-2-(4-hydroxy-phenyl)-quinolin-6-ol DMXNPSB MI TTOM3J0 DMXNPSB MN Estrogen receptor beta (ESR2) DMXNPSB MT DTT DMXNPSB MA Inhibitor DMXNPSB RN ERbeta ligands. Part 4: Synthesis and structure-activity relationships of a series of 2-phenylquinoline derivatives. Bioorg Med Chem Lett. 2005 Oct 15;15(20):4520-5. DMXNPSB RU https://pubmed.ncbi.nlm.nih.gov/16098741 DM9QBAZ DI DM9QBAZ DM9QBAZ DN 5-chloro-2-(4-phenylbutyl)isoindoline-1,3-dione DM9QBAZ MI TTECBXN DM9QBAZ MN Oxysterols receptor LXR-alpha (NR1H3) DM9QBAZ MT DTT DM9QBAZ MA Inhibitor DM9QBAZ RN Liver X receptor antagonists with a phthalimide skeleton derived from thalidomide-related glucosidase inhibitors. Bioorg Med Chem Lett. 2007 Jul 15;17(14):3957-61. DM9QBAZ RU https://pubmed.ncbi.nlm.nih.gov/17498949 DMJBHR9 DI DMJBHR9 DMJBHR9 DN 5-chloro-2-(pyridin-2-yl)-1H-benzo[d]imidazole DMJBHR9 MI TTZL0OI DMJBHR9 MN Methionine aminopeptidase 2 (METAP2) DMJBHR9 MT DTT DMJBHR9 MA Inhibitor DMJBHR9 RN Subtype-selectivity of metal-dependent methionine aminopeptidase inhibitors, Bioorg. Med. Chem. Lett. 20(14):4038-4044 (2010). DMJBHR9 RU http://www.sciencedirect.com/science/article/pii/S0960894X10007468 DM6YBZR DI DM6YBZR DM6YBZR DN 5-Chloro-2-methyl-3H-quinazolin-4-one DM6YBZR MI TTVDSZ0 DM6YBZR MN Poly [ADP-ribose] polymerase 1 (PARP1) DM6YBZR MT DTT DM6YBZR MA Inhibitor DM6YBZR RN Rational approaches to discovery of orally active and brain-penetrable quinazolinone inhibitors of poly(ADP-ribose)polymerase. J Med Chem. 2004 Aug 12;47(17):4151-4. DM6YBZR RU https://pubmed.ncbi.nlm.nih.gov/15293985 DMKEFJ0 DI DMKEFJ0 DMKEFJ0 DN 5-chloro-3,4-dihydroquinazolin-2-amine DMKEFJ0 MI TTSQIFT DMKEFJ0 MN 5-HT 1A receptor (HTR1A) DMKEFJ0 MT DTT DMKEFJ0 MA Inhibitor DMKEFJ0 RN Cyclic guanidines as dual 5-HT5A/5-HT7 receptor ligands: structure-activity relationship elucidation. Bioorg Med Chem Lett. 2008 Jan 1;18(1):256-61. DMKEFJ0 RU https://pubmed.ncbi.nlm.nih.gov/17998160 DMKEFJ0 DI DMKEFJ0 DMKEFJ0 DN 5-chloro-3,4-dihydroquinazolin-2-amine DMKEFJ0 MI TT6MSOK DMKEFJ0 MN 5-HT 1D receptor (HTR1D) DMKEFJ0 MT DTT DMKEFJ0 MA Inhibitor DMKEFJ0 RN Cyclic guanidines as dual 5-HT5A/5-HT7 receptor ligands: structure-activity relationship elucidation. Bioorg Med Chem Lett. 2008 Jan 1;18(1):256-61. DMKEFJ0 RU https://pubmed.ncbi.nlm.nih.gov/17998160 DMKEFJ0 DI DMKEFJ0 DMKEFJ0 DN 5-chloro-3,4-dihydroquinazolin-2-amine DMKEFJ0 MI TTJQOD7 DMKEFJ0 MN 5-HT 2A receptor (HTR2A) DMKEFJ0 MT DTT DMKEFJ0 MA Inhibitor DMKEFJ0 RN Cyclic guanidines as dual 5-HT5A/5-HT7 receptor ligands: structure-activity relationship elucidation. Bioorg Med Chem Lett. 2008 Jan 1;18(1):256-61. DMKEFJ0 RU https://pubmed.ncbi.nlm.nih.gov/17998160 DMKEFJ0 DI DMKEFJ0 DMKEFJ0 DN 5-chloro-3,4-dihydroquinazolin-2-amine DMKEFJ0 MI TTWJBZ5 DMKEFJ0 MN 5-HT 2C receptor (HTR2C) DMKEFJ0 MT DTT DMKEFJ0 MA Inhibitor DMKEFJ0 RN Cyclic guanidines as dual 5-HT5A/5-HT7 receptor ligands: structure-activity relationship elucidation. Bioorg Med Chem Lett. 2008 Jan 1;18(1):256-61. DMKEFJ0 RU https://pubmed.ncbi.nlm.nih.gov/17998160 DMKEFJ0 DI DMKEFJ0 DMKEFJ0 DN 5-chloro-3,4-dihydroquinazolin-2-amine DMKEFJ0 MI TTPC4TU DMKEFJ0 MN 5-HT 3A receptor (HTR3A) DMKEFJ0 MT DTT DMKEFJ0 MA Inhibitor DMKEFJ0 RN Cyclic guanidines as dual 5-HT5A/5-HT7 receptor ligands: structure-activity relationship elucidation. Bioorg Med Chem Lett. 2008 Jan 1;18(1):256-61. DMKEFJ0 RU https://pubmed.ncbi.nlm.nih.gov/17998160 DMKEFJ0 DI DMKEFJ0 DMKEFJ0 DN 5-chloro-3,4-dihydroquinazolin-2-amine DMKEFJ0 MI TTRUFDT DMKEFJ0 MN 5-HT 5A receptor (HTR5A) DMKEFJ0 MT DTT DMKEFJ0 MA Inhibitor DMKEFJ0 RN Cyclic guanidines as dual 5-HT5A/5-HT7 receptor ligands: structure-activity relationship elucidation. Bioorg Med Chem Lett. 2008 Jan 1;18(1):256-61. DMKEFJ0 RU https://pubmed.ncbi.nlm.nih.gov/17998160 DMKEFJ0 DI DMKEFJ0 DMKEFJ0 DN 5-chloro-3,4-dihydroquinazolin-2-amine DMKEFJ0 MI TTO9X1H DMKEFJ0 MN 5-HT 7 receptor (HTR7) DMKEFJ0 MT DTT DMKEFJ0 MA Inhibitor DMKEFJ0 RN Cyclic guanidines as dual 5-HT5A/5-HT7 receptor ligands: structure-activity relationship elucidation. Bioorg Med Chem Lett. 2008 Jan 1;18(1):256-61. DMKEFJ0 RU https://pubmed.ncbi.nlm.nih.gov/17998160 DM207CQ DI DM207CQ DM207CQ DN 5-Chloro-3-ethyl-1-(4-fluoro-phenyl)-1H-indole DM207CQ MI TTQ6VDM DM207CQ MN Voltage-gated potassium channel Kv11.1 (KCNH2) DM207CQ MT DTT DM207CQ MA Inhibitor DM207CQ RN Characterization of HERG potassium channel inhibition using CoMSiA 3D QSAR and homology modeling approaches. Bioorg Med Chem Lett. 2003 May 19;13(10):1829-35. DM207CQ RU https://pubmed.ncbi.nlm.nih.gov/12729675 DMGDTNI DI DMGDTNI DMGDTNI DN 5-chloro-4-ethyl-3,4-dihydroquinazolin-2-amine DMGDTNI MI TTSQIFT DMGDTNI MN 5-HT 1A receptor (HTR1A) DMGDTNI MT DTT DMGDTNI MA Inhibitor DMGDTNI RN Cyclic guanidines as dual 5-HT5A/5-HT7 receptor ligands: structure-activity relationship elucidation. Bioorg Med Chem Lett. 2008 Jan 1;18(1):256-61. DMGDTNI RU https://pubmed.ncbi.nlm.nih.gov/17998160 DMGDTNI DI DMGDTNI DMGDTNI DN 5-chloro-4-ethyl-3,4-dihydroquinazolin-2-amine DMGDTNI MI TTWJBZ5 DMGDTNI MN 5-HT 2C receptor (HTR2C) DMGDTNI MT DTT DMGDTNI MA Inhibitor DMGDTNI RN Cyclic guanidines as dual 5-HT5A/5-HT7 receptor ligands: structure-activity relationship elucidation. Bioorg Med Chem Lett. 2008 Jan 1;18(1):256-61. DMGDTNI RU https://pubmed.ncbi.nlm.nih.gov/17998160 DMGDTNI DI DMGDTNI DMGDTNI DN 5-chloro-4-ethyl-3,4-dihydroquinazolin-2-amine DMGDTNI MI TTRUFDT DMGDTNI MN 5-HT 5A receptor (HTR5A) DMGDTNI MT DTT DMGDTNI MA Inhibitor DMGDTNI RN Cyclic guanidines as dual 5-HT5A/5-HT7 receptor ligands: structure-activity relationship elucidation. Bioorg Med Chem Lett. 2008 Jan 1;18(1):256-61. DMGDTNI RU https://pubmed.ncbi.nlm.nih.gov/17998160 DMGDTNI DI DMGDTNI DMGDTNI DN 5-chloro-4-ethyl-3,4-dihydroquinazolin-2-amine DMGDTNI MI TTO9X1H DMGDTNI MN 5-HT 7 receptor (HTR7) DMGDTNI MT DTT DMGDTNI MA Inhibitor DMGDTNI RN Cyclic guanidines as dual 5-HT5A/5-HT7 receptor ligands: structure-activity relationship elucidation. Bioorg Med Chem Lett. 2008 Jan 1;18(1):256-61. DMGDTNI RU https://pubmed.ncbi.nlm.nih.gov/17998160 DM7FZU2 DI DM7FZU2 DM7FZU2 DN 5-chloro-4-methyl-3,4-dihydroquinazolin-2-amine DM7FZU2 MI TTSQIFT DM7FZU2 MN 5-HT 1A receptor (HTR1A) DM7FZU2 MT DTT DM7FZU2 MA Inhibitor DM7FZU2 RN Cyclic guanidines as dual 5-HT5A/5-HT7 receptor ligands: structure-activity relationship elucidation. Bioorg Med Chem Lett. 2008 Jan 1;18(1):256-61. DM7FZU2 RU https://pubmed.ncbi.nlm.nih.gov/17998160 DM7FZU2 DI DM7FZU2 DM7FZU2 DN 5-chloro-4-methyl-3,4-dihydroquinazolin-2-amine DM7FZU2 MI TT6MSOK DM7FZU2 MN 5-HT 1D receptor (HTR1D) DM7FZU2 MT DTT DM7FZU2 MA Inhibitor DM7FZU2 RN Cyclic guanidines as dual 5-HT5A/5-HT7 receptor ligands: structure-activity relationship elucidation. Bioorg Med Chem Lett. 2008 Jan 1;18(1):256-61. DM7FZU2 RU https://pubmed.ncbi.nlm.nih.gov/17998160 DM7FZU2 DI DM7FZU2 DM7FZU2 DN 5-chloro-4-methyl-3,4-dihydroquinazolin-2-amine DM7FZU2 MI TTWJBZ5 DM7FZU2 MN 5-HT 2C receptor (HTR2C) DM7FZU2 MT DTT DM7FZU2 MA Inhibitor DM7FZU2 RN Cyclic guanidines as dual 5-HT5A/5-HT7 receptor ligands: structure-activity relationship elucidation. Bioorg Med Chem Lett. 2008 Jan 1;18(1):256-61. DM7FZU2 RU https://pubmed.ncbi.nlm.nih.gov/17998160 DM7FZU2 DI DM7FZU2 DM7FZU2 DN 5-chloro-4-methyl-3,4-dihydroquinazolin-2-amine DM7FZU2 MI TTRUFDT DM7FZU2 MN 5-HT 5A receptor (HTR5A) DM7FZU2 MT DTT DM7FZU2 MA Inhibitor DM7FZU2 RN Cyclic guanidines as dual 5-HT5A/5-HT7 receptor ligands: structure-activity relationship elucidation. Bioorg Med Chem Lett. 2008 Jan 1;18(1):256-61. DM7FZU2 RU https://pubmed.ncbi.nlm.nih.gov/17998160 DM7FZU2 DI DM7FZU2 DM7FZU2 DN 5-chloro-4-methyl-3,4-dihydroquinazolin-2-amine DM7FZU2 MI TTO9X1H DM7FZU2 MN 5-HT 7 receptor (HTR7) DM7FZU2 MT DTT DM7FZU2 MA Inhibitor DM7FZU2 RN Cyclic guanidines as dual 5-HT5A/5-HT7 receptor ligands: structure-activity relationship elucidation. Bioorg Med Chem Lett. 2008 Jan 1;18(1):256-61. DM7FZU2 RU https://pubmed.ncbi.nlm.nih.gov/17998160 DMRS82Q DI DMRS82Q DMRS82Q DN 5-chloro-4-nitrothiophene-2-sulfonamide DMRS82Q MI TTSFWA7 DMRS82Q MN Plasmodium CDK Pfmrk (Malaria Pfmrk) DMRS82Q MT DTT DMRS82Q MA Inhibitor DMRS82Q RN Activity of substituted thiophene sulfonamides against malarial and mammalian cyclin dependent protein kinases, Bioorg. Med. Chem. Lett. 20(13):3863-3867 (2010). DMRS82Q RU http://www.sciencedirect.com/science/article/pii/S0960894X10006803 DMMT7WO DI DMMT7WO DMMT7WO DN 5-chloro-6-hydrazinouracil hydrochloride DMMT7WO MI TTO0IB8 DMMT7WO MN Thymidine phosphorylase (TYMP) DMMT7WO MT DTT DMMT7WO MA Inhibitor DMMT7WO RN Design and synthesis of novel 5,6-disubstituted uracil derivatives as potent inhibitors of thymidine phosphorylase. Bioorg Med Chem Lett. 2006 Mar 1;16(5):1335-7. DMMT7WO RU https://pubmed.ncbi.nlm.nih.gov/16337119 DM2SKP7 DI DM2SKP7 DM2SKP7 DN 5-Chloro-N-(4-ethylphenyl)benzo[d]oxazol-2-amine DM2SKP7 MI TT2J34L DM2SKP7 MN Arachidonate 5-lipoxygenase (5-LOX) DM2SKP7 MT DTT DM2SKP7 MA Inhibitor DM2SKP7 RN Synthesis and evaluation of benzoxazole derivatives as 5-lipoxygenase inhibitors. Bioorg Med Chem. 2010 Nov 1;18(21):7580-5. DM2SKP7 RU https://pubmed.ncbi.nlm.nih.gov/20870413 DMZ5MDY DI DMZ5MDY DMZ5MDY DN 5-chloro-N-(pyridin-3-yl)indoline-1-carboxamide DMZ5MDY MI TTJQOD7 DMZ5MDY MN 5-HT 2A receptor (HTR2A) DMZ5MDY MT DTT DMZ5MDY MA Inhibitor DMZ5MDY RN Synthesis and structure-affinity relationships of novel small molecule natural product derivatives capable of discriminating between serotonin 5-HT1A, 5-HT2A, 5-HT2C receptor subtypes. Bioorg Med Chem. 2010 Jul 1;18(13):4783-92. DMZ5MDY RU https://pubmed.ncbi.nlm.nih.gov/20570529 DMZ5MDY DI DMZ5MDY DMZ5MDY DN 5-chloro-N-(pyridin-3-yl)indoline-1-carboxamide DMZ5MDY MI TTWJBZ5 DMZ5MDY MN 5-HT 2C receptor (HTR2C) DMZ5MDY MT DTT DMZ5MDY MA Inhibitor DMZ5MDY RN Synthesis and structure-affinity relationships of novel small molecule natural product derivatives capable of discriminating between serotonin 5-HT1A, 5-HT2A, 5-HT2C receptor subtypes. Bioorg Med Chem. 2010 Jul 1;18(13):4783-92. DMZ5MDY RU https://pubmed.ncbi.nlm.nih.gov/20570529 DMMV931 DI DMMV931 DMMV931 DN 5-chloro-N-(quinolin-8-yl)thiophene-2-sulfonamide DMMV931 MI TTSXVID DMMV931 MN Nuclear factor NF-kappa-B (NFKB) DMMV931 MT DTT DMMV931 MA Inhibitor DMMV931 RN Identification of N-(quinolin-8-yl)benzenesulfonamides as agents capable of down-regulating NFkappaB activity within two separate high-throughput s... Bioorg Med Chem Lett. 2008 Jan 1;18(1):329-35. DMMV931 RU https://pubmed.ncbi.nlm.nih.gov/18024113 DMVQLFB DI DMVQLFB DMVQLFB DN 5-Chloro-N-phenylbenzo[d]oxazol-2-amine DMVQLFB MI TT2J34L DMVQLFB MN Arachidonate 5-lipoxygenase (5-LOX) DMVQLFB MT DTT DMVQLFB MA Inhibitor DMVQLFB RN Synthesis and evaluation of benzoxazole derivatives as 5-lipoxygenase inhibitors. Bioorg Med Chem. 2010 Nov 1;18(21):7580-5. DMVQLFB RU https://pubmed.ncbi.nlm.nih.gov/20870413 DMH397E DI DMH397E DMH397E DN 5-Chlorosalicylic Acid DMH397E MI TTHQPL7 DMH397E MN Carbonic anhydrase I (CA-I) DMH397E MT DTT DMH397E MA Inhibitor DMH397E RN In vitro inhibition of salicylic acid derivatives on human cytosolic carbonic anhydrase isozymes I and II. Bioorg Med Chem. 2008 Oct 15;16(20):9101-5. DMH397E RU https://pubmed.ncbi.nlm.nih.gov/18819808 DMH397E DI DMH397E DMH397E DN 5-Chlorosalicylic Acid DMH397E MI TTANPDJ DMH397E MN Carbonic anhydrase II (CA-II) DMH397E MT DTT DMH397E MA Inhibitor DMH397E RN In vitro inhibition of salicylic acid derivatives on human cytosolic carbonic anhydrase isozymes I and II. Bioorg Med Chem. 2008 Oct 15;16(20):9101-5. DMH397E RU https://pubmed.ncbi.nlm.nih.gov/18819808 DMWS3D6 DI DMWS3D6 DMWS3D6 DN 5-Chloryl-2,4,6-Quinazolinetriamine DMWS3D6 MI TT9SL3Q DMWS3D6 MN Polypeptide deformylase (PDF) DMWS3D6 MT DTT DMWS3D6 MA Inhibitor DMWS3D6 RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMWS3D6 RU https://pubmed.ncbi.nlm.nih.gov/17139284 DM109IL DI DM109IL DM109IL DN 5-Cl-5-deoxy-(+/-)-ENBA DM109IL MI TTK25J1 DM109IL MN Adenosine A1 receptor (ADORA1) DM109IL MT DTT DM109IL MA Agonist DM109IL RN N6-Cycloalkyl- and N6-bicycloalkyl-C5'(C2')-modified adenosine derivatives as high-affinity and selective agonists at the human A1 adenosine recept... J Med Chem. 2009 Apr 23;52(8):2393-406. DM109IL RU https://pubmed.ncbi.nlm.nih.gov/19317449 DM260KD DI DM260KD DM260KD DN 5-CT DM260KD MI TTSQIFT DM260KD MN 5-HT 1A receptor (HTR1A) DM260KD MT DTT DM260KD MA Agonist DM260KD RN Agonist activity of antimigraine drugs at recombinant human 5-HT1A receptors: potential implications for prophylactic and acute therapy. Naunyn Schmiedebergs Arch Pharmacol. 1997 Jun;355(6):682-8. DM260KD RU https://pubmed.ncbi.nlm.nih.gov/9205951 DM260KD DI DM260KD DM260KD DN 5-CT DM260KD MI TTK8CXU DM260KD MN 5-HT 1B receptor (HTR1B) DM260KD MT DTT DM260KD MA Agonist DM260KD RN Mouse 5HT1B serotonin receptor: cloning, functional expression, and localization in motor control centers. Proc Natl Acad Sci U S A. 1992 Apr 1;89(7):3020-4. DM260KD RU https://pubmed.ncbi.nlm.nih.gov/1557407 DM260KD DI DM260KD DM260KD DN 5-CT DM260KD MI TT6MSOK DM260KD MN 5-HT 1D receptor (HTR1D) DM260KD MT DTT DM260KD MA Agonist DM260KD RN Primary structure and functional characterization of a human 5-HT1D-type serotonin receptor. Mol Pharmacol. 1991 Aug;40(2):143-8. DM260KD RU https://pubmed.ncbi.nlm.nih.gov/1652050 DM260KD DI DM260KD DM260KD DN 5-CT DM260KD MI TTCPG9S DM260KD MN 5-HT 1E receptor (HTR1E) DM260KD MT DTT DM260KD MA Agonist DM260KD RN Molecular cloning and pharmacological characterization of the guinea pig 5-HT1E receptor. Eur J Pharmacol. 2004 Jan 26;484(2-3):127-39. DM260KD RU https://pubmed.ncbi.nlm.nih.gov/14744596 DM260KD DI DM260KD DM260KD DN 5-CT DM260KD MI TT0MI3F DM260KD MN 5-HT 1F receptor (HTR1F) DM260KD MT DTT DM260KD MA Agonist DM260KD RN Cloning and characterization of the guinea pig 5-HT1F receptor subtype: a comparison of the pharmacological profile to the human species homolog. Neuropharmacology. 1997 Apr-May;36(4-5):569-76. DM260KD RU https://pubmed.ncbi.nlm.nih.gov/9225282 DM260KD DI DM260KD DM260KD DN 5-CT DM260KD MI TTJQOD7 DM260KD MN 5-HT 2A receptor (HTR2A) DM260KD MT DTT DM260KD MA Agonist DM260KD RN Pharmacological characterisation of the agonist radioligand binding site of 5-HT(2A), 5-HT(2B) and 5-HT(2C) receptors. Naunyn Schmiedebergs Arch Pharmacol. 2004 Aug;370(2):114-23. DM260KD RU https://pubmed.ncbi.nlm.nih.gov/15322733 DM260KD DI DM260KD DM260KD DN 5-CT DM260KD MI TT0K1SC DM260KD MN 5-HT 2B receptor (HTR2B) DM260KD MT DTT DM260KD MA Agonist DM260KD RN Pharmacological characteristics of the newly cloned rat 5-hydroxytryptamine2F receptor. Mol Pharmacol. 1993 Mar;43(3):419-26. DM260KD RU https://pubmed.ncbi.nlm.nih.gov/8450835 DM260KD DI DM260KD DM260KD DN 5-CT DM260KD MI TTWJBZ5 DM260KD MN 5-HT 2C receptor (HTR2C) DM260KD MT DTT DM260KD MA Agonist DM260KD RN Agonist high and low affinity state ratios predict drug intrinsic activity and a revised ternary complex mechanism at serotonin 5-HT(2A) and 5-HT(2C) receptors. Synapse. 2000 Feb;35(2):144-50. DM260KD RU https://pubmed.ncbi.nlm.nih.gov/10611640 DM260KD DI DM260KD DM260KD DN 5-CT DM260KD MI TTRUFDT DM260KD MN 5-HT 5A receptor (HTR5A) DM260KD MT DTT DM260KD MA Agonist DM260KD RN Expression of functional mouse 5-HT5A serotonin receptor in the methylotrophic yeast Pichia pastoris: pharmacological characterization and localization. FEBS Lett. 1995 Dec 27;377(3):451-6. DM260KD RU https://pubmed.ncbi.nlm.nih.gov/8549774 DM260KD DI DM260KD DM260KD DN 5-CT DM260KD MI TTJS8PY DM260KD MN 5-HT 6 receptor (HTR6) DM260KD MT DTT DM260KD MA Agonist DM260KD RN Cloning, characterization, and chromosomal localization of a human 5-HT6 serotonin receptor. J Neurochem. 1996 Jan;66(1):47-56. DM260KD RU https://pubmed.ncbi.nlm.nih.gov/8522988 DM260KD DI DM260KD DM260KD DN 5-CT DM260KD MI TTO9X1H DM260KD MN 5-HT 7 receptor (HTR7) DM260KD MT DTT DM260KD MA Agonist DM260KD RN Molecular cloning of a mammalian serotonin receptor that activates adenylate cyclase. Mol Pharmacol. 1993 Aug;44(2):229-36. DM260KD RU https://pubmed.ncbi.nlm.nih.gov/8394987 DMMYENH DI DMMYENH DMMYENH DN 5-cyclohexyl-1,3,4-oxadiazole-2(3H)-thione DMMYENH MI TTULVH8 DMMYENH MN Tyrosinase (TYR) DMMYENH MT DTT DMMYENH MA Inhibitor DMMYENH RN New potent inhibitors of tyrosinase: novel clues to binding of 1,3,4-thiadiazole-2(3H)-thiones, 1,3,4-oxadiazole-2(3H)-thiones, 4-amino-1,2,4-triaz... Bioorg Med Chem. 2010 Jun 1;18(11):4042-8. DMMYENH RU https://pubmed.ncbi.nlm.nih.gov/20452224 DMRFH9U DI DMRFH9U DMRFH9U DN 5'-deoxy-4'-hydroxy-5'-methylthio-DADMe-ImmH DMRFH9U MI TTMCF1Y DMRFH9U MN Purine nucleoside phosphorylase (PNP) DMRFH9U MT DTT DMRFH9U MA Inhibitor DMRFH9U RN Immucillins in custom catalytic-site cavities. Bioorg Med Chem Lett. 2008 Nov 15;18(22):5900-3. DMRFH9U RU https://pubmed.ncbi.nlm.nih.gov/18778937 DMR28HG DI DMR28HG DMR28HG DN 5'-Deoxy-5'-(Methylthio)-Tubercidin DMR28HG MI TTFSX6G DMR28HG MN Bacterial MTA/SAH nucleosidase (Bact mtnN) DMR28HG MT DTT DMR28HG MA Inhibitor DMR28HG RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMR28HG RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMR28HG DI DMR28HG DMR28HG DN 5'-Deoxy-5'-(Methylthio)-Tubercidin DMR28HG MI TTDBX7N DMR28HG MN S-methyl-5'-thioadenosine phosphorylase (MTAP) DMR28HG MT DTT DMR28HG MA Inhibitor DMR28HG RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMR28HG RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMOHSY0 DI DMOHSY0 DMOHSY0 DN 5'-Deoxy-5'-(N,N-dimethylamino)-8-methyladenosine DMOHSY0 MI TTBFROQ DMOHSY0 MN S-adenosylmethionine decarboxylase proenzyme (AMD1) DMOHSY0 MT DTT DMOHSY0 MA Inhibitor DMOHSY0 RN New insights into the design of inhibitors of human S-adenosylmethionine decarboxylase: studies of adenine C8 substitution in structural analogues ... J Med Chem. 2009 Mar 12;52(5):1388-407. DMOHSY0 RU https://pubmed.ncbi.nlm.nih.gov/19209891 DMF7JPO DI DMF7JPO DMF7JPO DN 5'-Deoxy-5'-(N,N-dimethylamino)adenosine DMF7JPO MI TTBFROQ DMF7JPO MN S-adenosylmethionine decarboxylase proenzyme (AMD1) DMF7JPO MT DTT DMF7JPO MA Inhibitor DMF7JPO RN New insights into the design of inhibitors of human S-adenosylmethionine decarboxylase: studies of adenine C8 substitution in structural analogues ... J Med Chem. 2009 Mar 12;52(5):1388-407. DMF7JPO RU https://pubmed.ncbi.nlm.nih.gov/19209891 DM6HGUL DI DM6HGUL DM6HGUL DN 5'-deoxy-5'-[(3-hydrazinopropyl)methylamino]adenosine DM6HGUL MI TTVF2BJ DM6HGUL MN Lactosylceramide alpha-2,3-sialyltransferase (ST3GAL5) DM6HGUL MT DTT DM6HGUL MA Inhibitor DM6HGUL RN S-adenosylmethionine decarboxylase as an enzyme target for therapy. Pharmacol Ther. 1992 Dec;56(3):359-77. DM6HGUL RU https://pubmed.ncbi.nlm.nih.gov/1301596 DM6HGUL DI DM6HGUL DM6HGUL DN 5'-deoxy-5'-[(3-hydrazinopropyl)methylamino]adenosine DM6HGUL MI TTBFROQ DM6HGUL MN S-adenosylmethionine decarboxylase proenzyme (AMD1) DM6HGUL MT DTT DM6HGUL MA Inhibitor DM6HGUL RN S-adenosylmethionine decarboxylase as an enzyme target for therapy. Pharmacol Ther. 1992 Dec;56(3):359-77. DM6HGUL RU https://pubmed.ncbi.nlm.nih.gov/1301596 DM1NAMK DI DM1NAMK DM1NAMK DN 5'-Deoxy-5'-dimethylsulfonioadenosine chloride DM1NAMK MI TTBFROQ DM1NAMK MN S-adenosylmethionine decarboxylase proenzyme (AMD1) DM1NAMK MT DTT DM1NAMK MA Inhibitor DM1NAMK RN New insights into the design of inhibitors of human S-adenosylmethionine decarboxylase: studies of adenine C8 substitution in structural analogues ... J Med Chem. 2009 Mar 12;52(5):1388-407. DM1NAMK RU https://pubmed.ncbi.nlm.nih.gov/19209891 DMU4MCK DI DMU4MCK DMU4MCK DN 5'-Deoxy-5'-phenyladenophostin A DMU4MCK MI TTC9IZL DMU4MCK MN Inositol 1,4,5-trisphosphate receptor (ITPR) DMU4MCK MT DTT DMU4MCK MA Inhibitor DMU4MCK RN Synthesis of adenophostin A analogues conjugating an aromatic group at the 5'-position as potent IP3 receptor ligands. J Med Chem. 2006 Sep 21;49(19):5750-8. DMU4MCK RU https://pubmed.ncbi.nlm.nih.gov/16970399 DM65XZJ DI DM65XZJ DM65XZJ DN 5-deoxy-5-phosphono-D-arabinonate DM65XZJ MI TTZ3IFB DM65XZJ MN Phosphogluconate dehydrogenase (PGD) DM65XZJ MT DTT DM65XZJ MA Inhibitor DM65XZJ RN Sugar derivatives as new 6-phosphogluconate dehydrogenase inhibitors selective for the parasite Trypanosoma brucei. Bioorg Med Chem. 2003 Apr 3;11(7):1207-14. DM65XZJ RU https://pubmed.ncbi.nlm.nih.gov/12628648 DM8IQX4 DI DM8IQX4 DM8IQX4 DN 5'-deoxy-5'-ureidoadenosine DM8IQX4 MI TTE2KUJ DM8IQX4 MN Adenosylhomocysteinase (AHCY) DM8IQX4 MT DTT DM8IQX4 MA Inhibitor DM8IQX4 RN Design, synthesis, and molecular modeling studies of 5'-deoxy-5'-ureidoadenosine: 5'-ureido group as multiple hydrogen bonding donor in the active ... Bioorg Med Chem Lett. 2007 Aug 15;17(16):4456-9. DM8IQX4 RU https://pubmed.ncbi.nlm.nih.gov/17582766 DM1Q0BF DI DM1Q0BF DM1Q0BF DN 5-deoxyabyssinin II DM1Q0BF MI TTELIN2 DM1Q0BF MN PTPN1 messenger RNA (PTPN1 mRNA) DM1Q0BF MT DTT DM1Q0BF MA Inhibitor DM1Q0BF RN Isoprenylated flavonoids from the stem bark of Erythrina abyssinica. J Nat Prod. 2007 Jun;70(6):1039-42. DM1Q0BF RU https://pubmed.ncbi.nlm.nih.gov/17489632 DMR48NG DI DMR48NG DMR48NG DN 5'-deoxythymidine DMR48NG MI TT5B8AX DMR48NG MN Mycobacterium Thymidine monophosphate kinase (MycB tmk) DMR48NG MT DTT DMR48NG MA Inhibitor DMR48NG RN Thymidylate kinase as target enzyme for 5'-deoxythymidine and various 5'-deoxy-5'-halogeno pyrimidine nucleosides. Acta Biol Med Ger. 1969;23(6):Suppl:K 19+. DMR48NG RU https://pubmed.ncbi.nlm.nih.gov/5375492 DM6TM1L DI DM6TM1L DM6TM1L DN 5-desgalloylstachyurin DM6TM1L MI TT6L509 DM6TM1L MN Coagulation factor IIa (F2) DM6TM1L MT DTT DM6TM1L MA Inhibitor DM6TM1L RN Effects of tannins from Geum japonicum on the catalytic activity of thrombin and factor Xa of blood coagulation cascade. J Nat Prod. 1998 Nov;61(11):1356-60. DM6TM1L RU https://pubmed.ncbi.nlm.nih.gov/9834152 DM6TM1L DI DM6TM1L DM6TM1L DN 5-desgalloylstachyurin DM6TM1L MI TTCIHJA DM6TM1L MN Coagulation factor Xa (F10) DM6TM1L MT DTT DM6TM1L MA Inhibitor DM6TM1L RN Effects of tannins from Geum japonicum on the catalytic activity of thrombin and factor Xa of blood coagulation cascade. J Nat Prod. 1998 Nov;61(11):1356-60. DM6TM1L RU https://pubmed.ncbi.nlm.nih.gov/9834152 DMX64E3 DI DMX64E3 DMX64E3 DN 5-ethyl-2-(2-(pyrrolidin-1-yl)ethyl)pyridine DMX64E3 MI TT9JNIC DMX64E3 MN Histamine H3 receptor (H3R) DMX64E3 MT DTT DMX64E3 MA Inhibitor DMX64E3 RN In vitro SAR of pyrrolidine-containing histamine H3 receptor antagonists: trends across multiple chemical series. Bioorg Med Chem Lett. 2008 Jan 1;18(1):355-9. DMX64E3 RU https://pubmed.ncbi.nlm.nih.gov/18077160 DM0E9O1 DI DM0E9O1 DM0E9O1 DN 5-ethyl-2-(phenylsulfonamido)benzoic acid DM0E9O1 MI TTZL0OI DM0E9O1 MN Methionine aminopeptidase 2 (METAP2) DM0E9O1 MT DTT DM0E9O1 MA Inhibitor DM0E9O1 RN Development of sulfonamide compounds as potent methionine aminopeptidase type II inhibitors with antiproliferative properties. Bioorg Med Chem Lett. 2006 Jul 1;16(13):3574-7. DM0E9O1 RU https://pubmed.ncbi.nlm.nih.gov/16632353 DMK57W2 DI DMK57W2 DMK57W2 DN 5-Ethyl-3-(2-pyrrolidin-1-yl-ethyl)-1H-indole DMK57W2 MI TTK8CXU DMK57W2 MN 5-HT 1B receptor (HTR1B) DMK57W2 MT DTT DMK57W2 MA Inhibitor DMK57W2 RN 5-Alkyltryptamine derivatives as highly selective and potent 5-HT1D receptor agonists. Bioorg Med Chem Lett. 2000 Aug 7;10(15):1707-9. DMK57W2 RU https://pubmed.ncbi.nlm.nih.gov/10937729 DMK57W2 DI DMK57W2 DMK57W2 DN 5-Ethyl-3-(2-pyrrolidin-1-yl-ethyl)-1H-indole DMK57W2 MI TT6MSOK DMK57W2 MN 5-HT 1D receptor (HTR1D) DMK57W2 MT DTT DMK57W2 MA Inhibitor DMK57W2 RN 5-Alkyltryptamine derivatives as highly selective and potent 5-HT1D receptor agonists. Bioorg Med Chem Lett. 2000 Aug 7;10(15):1707-9. DMK57W2 RU https://pubmed.ncbi.nlm.nih.gov/10937729 DMRIGXA DI DMRIGXA DMRIGXA DN 5-Ethyl-3,4-diphenyl-isoxazole DMRIGXA MI TT8NGED DMRIGXA MN Prostaglandin G/H synthase 1 (COX-1) DMRIGXA MT DTT DMRIGXA MA Inhibitor DMRIGXA RN Novel synthesis of 3,4-diarylisoxazole analogues of valdecoxib: reversal cyclooxygenase-2 selectivity by sulfonamide group removal. J Med Chem. 2004 Sep 23;47(20):4881-90. DMRIGXA RU https://pubmed.ncbi.nlm.nih.gov/15369392 DMRIGXA DI DMRIGXA DMRIGXA DN 5-Ethyl-3,4-diphenyl-isoxazole DMRIGXA MI TTVKILB DMRIGXA MN Prostaglandin G/H synthase 2 (COX-2) DMRIGXA MT DTT DMRIGXA MA Inhibitor DMRIGXA RN Novel synthesis of 3,4-diarylisoxazole analogues of valdecoxib: reversal cyclooxygenase-2 selectivity by sulfonamide group removal. J Med Chem. 2004 Sep 23;47(20):4881-90. DMRIGXA RU https://pubmed.ncbi.nlm.nih.gov/15369392 DMYD8GP DI DMYD8GP DMYD8GP DN 5-Ethyl-3-methyl-5-phenyl-oxazolidine-2,4-dione DMYD8GP MI TTRK8B9 DMYD8GP MN Sodium channel unspecific (NaC) DMYD8GP MT DTT DMYD8GP MA Inhibitor DMYD8GP RN Sodium channel binding and anticonvulsant activities for the enantiomers of a bicyclic 2,4-oxazolidinedione and monocyclic models. J Med Chem. 1989 Jul;32(7):1577-80. DMYD8GP RU https://pubmed.ncbi.nlm.nih.gov/2544727 DMYD8GP DI DMYD8GP DMYD8GP DN 5-Ethyl-3-methyl-5-phenyl-oxazolidine-2,4-dione DMYD8GP MI TTAXZ0K DMYD8GP MN Voltage-gated sodium channel alpha Nav1.3 (SCN3A) DMYD8GP MT DTT DMYD8GP MA Inhibitor DMYD8GP RN Sodium channel binding and anticonvulsant activities for the enantiomers of a bicyclic 2,4-oxazolidinedione and monocyclic models. J Med Chem. 1989 Jul;32(7):1577-80. DMYD8GP RU https://pubmed.ncbi.nlm.nih.gov/2544727 DMS9TFC DI DMS9TFC DMS9TFC DN 5-Ethyl-3-methyl-pyrrolidin-(2Z)-ylideneamine DMS9TFC MI TTZUFI5 DMS9TFC MN Nitric-oxide synthase brain (NOS1) DMS9TFC MT DTT DMS9TFC MA Inhibitor DMS9TFC RN Evaluation of pyrrolidin-2-imines and 1,3-thiazolidin-2-imines as inhibitors of nitric oxide synthase. Bioorg Med Chem Lett. 2004 Sep 6;14(17):4539-44. DMS9TFC RU https://pubmed.ncbi.nlm.nih.gov/15357988 DMS9TFC DI DMS9TFC DMS9TFC DN 5-Ethyl-3-methyl-pyrrolidin-(2Z)-ylideneamine DMS9TFC MI TTCM4B3 DMS9TFC MN Nitric-oxide synthase endothelial (NOS3) DMS9TFC MT DTT DMS9TFC MA Inhibitor DMS9TFC RN Evaluation of pyrrolidin-2-imines and 1,3-thiazolidin-2-imines as inhibitors of nitric oxide synthase. Bioorg Med Chem Lett. 2004 Sep 6;14(17):4539-44. DMS9TFC RU https://pubmed.ncbi.nlm.nih.gov/15357988 DMQWOIG DI DMQWOIG DMQWOIG DN 5-Ethyl-4-methyl-pyrrolidin-(2Z)-ylideneamine DMQWOIG MI TTZUFI5 DMQWOIG MN Nitric-oxide synthase brain (NOS1) DMQWOIG MT DTT DMQWOIG MA Inhibitor DMQWOIG RN Evaluation of pyrrolidin-2-imines and 1,3-thiazolidin-2-imines as inhibitors of nitric oxide synthase. Bioorg Med Chem Lett. 2004 Sep 6;14(17):4539-44. DMQWOIG RU https://pubmed.ncbi.nlm.nih.gov/15357988 DMQWOIG DI DMQWOIG DMQWOIG DN 5-Ethyl-4-methyl-pyrrolidin-(2Z)-ylideneamine DMQWOIG MI TTCM4B3 DMQWOIG MN Nitric-oxide synthase endothelial (NOS3) DMQWOIG MT DTT DMQWOIG MA Inhibitor DMQWOIG RN Evaluation of pyrrolidin-2-imines and 1,3-thiazolidin-2-imines as inhibitors of nitric oxide synthase. Bioorg Med Chem Lett. 2004 Sep 6;14(17):4539-44. DMQWOIG RU https://pubmed.ncbi.nlm.nih.gov/15357988 DMQWOIG DI DMQWOIG DMQWOIG DN 5-Ethyl-4-methyl-pyrrolidin-(2Z)-ylideneamine DMQWOIG MI TTF10I9 DMQWOIG MN Nitric-oxide synthase inducible (NOS2) DMQWOIG MT DTT DMQWOIG MA Inhibitor DMQWOIG RN Evaluation of pyrrolidin-2-imines and 1,3-thiazolidin-2-imines as inhibitors of nitric oxide synthase. Bioorg Med Chem Lett. 2004 Sep 6;14(17):4539-44. DMQWOIG RU https://pubmed.ncbi.nlm.nih.gov/15357988 DMSA8X2 DI DMSA8X2 DMSA8X2 DN 5-Ethyl-4-propyl-pyrrolidin-(2Z)-ylideneamine DMSA8X2 MI TTZUFI5 DMSA8X2 MN Nitric-oxide synthase brain (NOS1) DMSA8X2 MT DTT DMSA8X2 MA Inhibitor DMSA8X2 RN Evaluation of pyrrolidin-2-imines and 1,3-thiazolidin-2-imines as inhibitors of nitric oxide synthase. Bioorg Med Chem Lett. 2004 Sep 6;14(17):4539-44. DMSA8X2 RU https://pubmed.ncbi.nlm.nih.gov/15357988 DMSA8X2 DI DMSA8X2 DMSA8X2 DN 5-Ethyl-4-propyl-pyrrolidin-(2Z)-ylideneamine DMSA8X2 MI TTF10I9 DMSA8X2 MN Nitric-oxide synthase inducible (NOS2) DMSA8X2 MT DTT DMSA8X2 MA Inhibitor DMSA8X2 RN Evaluation of pyrrolidin-2-imines and 1,3-thiazolidin-2-imines as inhibitors of nitric oxide synthase. Bioorg Med Chem Lett. 2004 Sep 6;14(17):4539-44. DMSA8X2 RU https://pubmed.ncbi.nlm.nih.gov/15357988 DM8Y4G5 DI DM8Y4G5 DM8Y4G5 DN 5-Ethyl-oxazolidin-(2Z)-ylideneamine DM8Y4G5 MI TTZUFI5 DM8Y4G5 MN Nitric-oxide synthase brain (NOS1) DM8Y4G5 MT DTT DM8Y4G5 MA Inhibitor DM8Y4G5 RN 4,5-Disubstituted-1,3-oxazolidin-2-imine derivatives: a new class of orally bioavailable nitric oxide synthase inhibitor. Bioorg Med Chem Lett. 2004 Jan 19;14(2):313-6. DM8Y4G5 RU https://pubmed.ncbi.nlm.nih.gov/14698148 DM8Y4G5 DI DM8Y4G5 DM8Y4G5 DN 5-Ethyl-oxazolidin-(2Z)-ylideneamine DM8Y4G5 MI TTF10I9 DM8Y4G5 MN Nitric-oxide synthase inducible (NOS2) DM8Y4G5 MT DTT DM8Y4G5 MA Inhibitor DM8Y4G5 RN 4,5-Disubstituted-1,3-oxazolidin-2-imine derivatives: a new class of orally bioavailable nitric oxide synthase inhibitor. Bioorg Med Chem Lett. 2004 Jan 19;14(2):313-6. DM8Y4G5 RU https://pubmed.ncbi.nlm.nih.gov/14698148 DMLSC10 DI DMLSC10 DMLSC10 DN 5-Fluoro orotate DMLSC10 MI TT09NOX DMLSC10 MN Plasmodium Dihydroorotase (Malaria dho) DMLSC10 MT DTT DMLSC10 MA Inhibitor DMLSC10 RN Antimalarial activity of orotate analogs that inhibit dihydroorotase and dihydroorotate dehydrogenase. Biochem Pharmacol. 1992 Mar 17;43(6):1295-301. DMLSC10 RU https://pubmed.ncbi.nlm.nih.gov/1348618 DMLSC10 DI DMLSC10 DMLSC10 DN 5-Fluoro orotate DMLSC10 MI TT3PQ2Y DMLSC10 MN Plasmodium Dihydroorotate dehydrogenase (Malaria DHOdehase) DMLSC10 MT DTT DMLSC10 MA Inhibitor DMLSC10 RN Antimalarial activity of orotate analogs that inhibit dihydroorotase and dihydroorotate dehydrogenase. Biochem Pharmacol. 1992 Mar 17;43(6):1295-301. DMLSC10 RU https://pubmed.ncbi.nlm.nih.gov/1348618 DM9U1HV DI DM9U1HV DM9U1HV DN 5-fluoro-1H-indole-2-carboxylic acid DM9U1HV MI TTHGL48 DM9U1HV MN AP endonuclease 1 (APEX1) DM9U1HV MT DTT DM9U1HV MA Inhibitor DM9U1HV RN Development and evaluation of human AP endonuclease inhibitors in melanoma and glioma cell lines. Br J Cancer. 2011 Feb 15;104(4):653-63. DM9U1HV RU https://pubmed.ncbi.nlm.nih.gov/21266972 DMEA8WP DI DMEA8WP DMEA8WP DN 5-fluoro-2-(pyridin-2-yl)-1H-benzo[d]imidazole DMEA8WP MI TTZL0OI DMEA8WP MN Methionine aminopeptidase 2 (METAP2) DMEA8WP MT DTT DMEA8WP MA Inhibitor DMEA8WP RN Subtype-selectivity of metal-dependent methionine aminopeptidase inhibitors, Bioorg. Med. Chem. Lett. 20(14):4038-4044 (2010). DMEA8WP RU http://www.sciencedirect.com/science/article/pii/S0960894X10007468 DME1AGO DI DME1AGO DME1AGO DN 5-Fluoro-2'-Deoxyuridine-5'-Monophosphate DME1AGO MI TTU6BFZ DME1AGO MN Candida Thymidylate synthase (Candi TMP1) DME1AGO MT DTT DME1AGO MA Inhibitor DME1AGO RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DME1AGO RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMOI7ME DI DMOI7ME DMOI7ME DN 5-Fluoro-2-hydroxy-N-isopropyl-benzamide DMOI7ME MI TT64EPS DMOI7ME MN Fungal Scytalone dehydratase (Fung SDH1) DMOI7ME MT DTT DMOI7ME MA Inhibitor DMOI7ME RN Binding dynamics of two water molecules constrained within the scytalone dehydratase binding pocket. Bioorg Med Chem Lett. 2000 Jan 3;10(1):23-6. DMOI7ME RU https://pubmed.ncbi.nlm.nih.gov/10636235 DMUCLAV DI DMUCLAV DMUCLAV DN 5-Fluoro-2-sulfanyl-phenylphosphonic acid DMUCLAV MI TTHI19T DMUCLAV MN Staphylococcus Beta-lactamase (Stap-coc blaZ) DMUCLAV MT DTT DMUCLAV MA Inhibitor DMUCLAV RN Mercaptophosphonate compounds as broad-spectrum inhibitors of the metallo-beta-lactamases. J Med Chem. 2010 Jul 8;53(13):4862-76. DMUCLAV RU https://pubmed.ncbi.nlm.nih.gov/20527888 DM0OQTJ DI DM0OQTJ DM0OQTJ DN 5-Fluoro-3-thiophen-3-yl-quinoline DM0OQTJ MI TT8FYO9 DM0OQTJ MN Platelet-derived growth factor receptor alpha (PDGFRA) DM0OQTJ MT DTT DM0OQTJ MA Inhibitor DM0OQTJ RN A new series of PDGF receptor tyrosine kinase inhibitors: 3-substituted quinoline derivatives. J Med Chem. 1994 Jul 8;37(14):2129-37. DM0OQTJ RU https://pubmed.ncbi.nlm.nih.gov/8035419 DMEV0GO DI DMEV0GO DMEV0GO DN 5-fluoro-6-[(2-aminoimidazol-1-yl)methyl]uracil DMEV0GO MI TTO0IB8 DMEV0GO MN Thymidine phosphorylase (TYMP) DMEV0GO MT DTT DMEV0GO MA Inhibitor DMEV0GO RN The role of phosphate in the action of thymidine phosphorylase inhibitors: Implications for the catalytic mechanism. Bioorg Med Chem Lett. 2010 Mar 1;20(5):1648-51. DMEV0GO RU https://pubmed.ncbi.nlm.nih.gov/20138520 DM6QHIA DI DM6QHIA DM6QHIA DN 5-fluoro-6-amino-UMP DM6QHIA MI TTAFJUD DM6QHIA MN Orotidine 5'-monophosphate decarboxylase (UMPS) DM6QHIA MT DTT DM6QHIA MA Inhibitor DM6QHIA RN Structure-activity relationships of orotidine-5'-monophosphate decarboxylase inhibitors as anticancer agents. J Med Chem. 2009 Mar 26;52(6):1648-58. DM6QHIA RU https://pubmed.ncbi.nlm.nih.gov/19260677 DMZLJRS DI DMZLJRS DMZLJRS DN 5-fluoro-6-azido-UMP DMZLJRS MI TTAFJUD DMZLJRS MN Orotidine 5'-monophosphate decarboxylase (UMPS) DMZLJRS MT DTT DMZLJRS MA Inhibitor DMZLJRS RN Structure-activity relationships of orotidine-5'-monophosphate decarboxylase inhibitors as anticancer agents. J Med Chem. 2009 Mar 26;52(6):1648-58. DMZLJRS RU https://pubmed.ncbi.nlm.nih.gov/19260677 DMTAZ71 DI DMTAZ71 DMTAZ71 DN 5-Fluoro-6-ethyluridine-5'-O-monophosphate DMTAZ71 MI TTAFJUD DMTAZ71 MN Orotidine 5'-monophosphate decarboxylase (UMPS) DMTAZ71 MT DTT DMTAZ71 MA Inhibitor DMTAZ71 RN Structure-activity relationships of orotidine-5'-monophosphate decarboxylase inhibitors as anticancer agents. J Med Chem. 2009 Mar 26;52(6):1648-58. DMTAZ71 RU https://pubmed.ncbi.nlm.nih.gov/19260677 DM3LMIS DI DM3LMIS DM3LMIS DN 5-fluoro-6-iodo-UMP DM3LMIS MI TTAFJUD DM3LMIS MN Orotidine 5'-monophosphate decarboxylase (UMPS) DM3LMIS MT DTT DM3LMIS MA Inhibitor DM3LMIS RN Structure-activity relationships of orotidine-5'-monophosphate decarboxylase inhibitors as anticancer agents. J Med Chem. 2009 Mar 26;52(6):1648-58. DM3LMIS RU https://pubmed.ncbi.nlm.nih.gov/19260677 DMDV48S DI DMDV48S DMDV48S DN 5-Fluorolevulinic Acid DMDV48S MI TTJHKYD DMDV48S MN Delta-aminolevulinic acid dehydratase (ALAD) DMDV48S MT DTT DMDV48S MA Inhibitor DMDV48S RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMDV48S RU https://pubmed.ncbi.nlm.nih.gov/17139284 DM371WE DI DM371WE DM371WE DN 5-Formyl-6-Hydrofolic Acid DM371WE MI TT9SL3Q DM371WE MN Polypeptide deformylase (PDF) DM371WE MT DTT DM371WE MA Inhibitor DM371WE RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DM371WE RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMIARG7 DI DMIARG7 DMIARG7 DN 5'-Guanosine-Diphosphate-Monothiophosphate DMIARG7 MI TT4W1VJ DMIARG7 MN Bacterial Celldivision protein FtsZ (Bact ftsZ) DMIARG7 MT DTT DMIARG7 MA Inhibitor DMIARG7 RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMIARG7 RU https://pubmed.ncbi.nlm.nih.gov/17139284 DM1SON5 DI DM1SON5 DM1SON5 DN 5H-6-thia-4,5-diaza-chrysene 6,6-dioxide DM1SON5 MI TTSXVID DM1SON5 MN Nuclear factor NF-kappa-B (NFKB) DM1SON5 MT DTT DM1SON5 MA Inhibitor DM1SON5 RN Identification of N-(quinolin-8-yl)benzenesulfonamides as agents capable of down-regulating NFkappaB activity within two separate high-throughput s... Bioorg Med Chem Lett. 2008 Jan 1;18(1):329-35. DM1SON5 RU https://pubmed.ncbi.nlm.nih.gov/18024113 DMKUT6A DI DMKUT6A DMKUT6A DN 5-HEAT DMKUT6A MI TT0WAIE DMKUT6A MN Melatonin receptor type 1A (MTNR1A) DMKUT6A MT DTT DMKUT6A MA Agonist DMKUT6A RN A new melatonin receptor ligand with mt1-agonist and MT2-antagonist properties. J Pineal Res. 2000 Nov;29(4):234-40. DMKUT6A RU https://pubmed.ncbi.nlm.nih.gov/11068946 DMICKOU DI DMICKOU DMICKOU DN 5-Heptyl-5-phenyl-imidazolidine-2,4-dione DMICKOU MI TTRK8B9 DMICKOU MN Sodium channel unspecific (NaC) DMICKOU MT DTT DMICKOU MA Inhibitor DMICKOU RN Comparative molecular field analysis of hydantoin binding to the neuronal voltage-dependent sodium channel. J Med Chem. 1999 May 6;42(9):1537-45. DMICKOU RU https://pubmed.ncbi.nlm.nih.gov/10229624 DMICKOU DI DMICKOU DMICKOU DN 5-Heptyl-5-phenyl-imidazolidine-2,4-dione DMICKOU MI TTAXZ0K DMICKOU MN Voltage-gated sodium channel alpha Nav1.3 (SCN3A) DMICKOU MT DTT DMICKOU MA Inhibitor DMICKOU RN Comparative molecular field analysis of hydantoin binding to the neuronal voltage-dependent sodium channel. J Med Chem. 1999 May 6;42(9):1537-45. DMICKOU RU https://pubmed.ncbi.nlm.nih.gov/10229624 DM49F6Z DI DM49F6Z DM49F6Z DN 5-heptyl-6-hydroxy-1,3-benzothiazole-4,7-dione DM49F6Z MI TTRAMF0 DM49F6Z MN Plasmodium Cytochrome B (Malaria MT-CYB) DM49F6Z MT DTT DM49F6Z MA Inhibitor DM49F6Z RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DM49F6Z RU https://pubmed.ncbi.nlm.nih.gov/10592235 DMHGQRF DI DMHGQRF DMHGQRF DN 5-Hex-5-enyl-2-nonyl-3,4-dihydro-2H-pyrrole DMHGQRF MI TT1RS9F DMHGQRF MN Acetylcholinesterase (AChE) DMHGQRF MT DTT DMHGQRF MA Inhibitor DMHGQRF RN Acetylcholinesterase inhibition by alkaloids of the ant's venom Monomorium minutum, Bioorg. Med. Chem. Lett. 5(11):1131-1132 (1995). DMHGQRF RU http://www.sciencedirect.com/science/article/pii/0960894X9500179W DM0OJZF DI DM0OJZF DM0OJZF DN 5-hexyl-2-(2-nitrophenoxy)phenol DM0OJZF MI TTVTX4N DM0OJZF MN Bacterial Fatty acid synthetase I (Bact inhA) DM0OJZF MT DTT DM0OJZF MA Inhibitor DM0OJZF RN Synthesis and in vitro antimycobacterial activity of B-ring modified diaryl ether InhA inhibitors. Bioorg Med Chem Lett. 2008 May 15;18(10):3029-33. DM0OJZF RU https://pubmed.ncbi.nlm.nih.gov/18457948 DM7EBQL DI DM7EBQL DM7EBQL DN 5-hexyl-2-(3-nitrophenoxy)phenol DM7EBQL MI TTVTX4N DM7EBQL MN Bacterial Fatty acid synthetase I (Bact inhA) DM7EBQL MT DTT DM7EBQL MA Inhibitor DM7EBQL RN Synthesis and in vitro antimycobacterial activity of B-ring modified diaryl ether InhA inhibitors. Bioorg Med Chem Lett. 2008 May 15;18(10):3029-33. DM7EBQL RU https://pubmed.ncbi.nlm.nih.gov/18457948 DMNBLPA DI DMNBLPA DMNBLPA DN 5-hexyl-2-(4-nitrophenoxy)phenol DMNBLPA MI TTVTX4N DMNBLPA MN Bacterial Fatty acid synthetase I (Bact inhA) DMNBLPA MT DTT DMNBLPA MA Inhibitor DMNBLPA RN Synthesis and in vitro antimycobacterial activity of B-ring modified diaryl ether InhA inhibitors. Bioorg Med Chem Lett. 2008 May 15;18(10):3029-33. DMNBLPA RU https://pubmed.ncbi.nlm.nih.gov/18457948 DM9263J DI DM9263J DM9263J DN 5-hexyl-2-(pyrazin-2-yloxy)phenol DM9263J MI TTVTX4N DM9263J MN Bacterial Fatty acid synthetase I (Bact inhA) DM9263J MT DTT DM9263J MA Inhibitor DM9263J RN Synthesis and in vitro antimycobacterial activity of B-ring modified diaryl ether InhA inhibitors. Bioorg Med Chem Lett. 2008 May 15;18(10):3029-33. DM9263J RU https://pubmed.ncbi.nlm.nih.gov/18457948 DMLIMOP DI DMLIMOP DMLIMOP DN 5-hexyl-2-(pyridin-2-yloxy)phenol DMLIMOP MI TTVTX4N DMLIMOP MN Bacterial Fatty acid synthetase I (Bact inhA) DMLIMOP MT DTT DMLIMOP MA Inhibitor DMLIMOP RN Synthesis and in vitro antimycobacterial activity of B-ring modified diaryl ether InhA inhibitors. Bioorg Med Chem Lett. 2008 May 15;18(10):3029-33. DMLIMOP RU https://pubmed.ncbi.nlm.nih.gov/18457948 DMHZT1S DI DMHZT1S DMHZT1S DN 5-hexyl-2-(pyridin-3-yloxy)phenol DMHZT1S MI TTVTX4N DMHZT1S MN Bacterial Fatty acid synthetase I (Bact inhA) DMHZT1S MT DTT DMHZT1S MA Inhibitor DMHZT1S RN Synthesis and in vitro antimycobacterial activity of B-ring modified diaryl ether InhA inhibitors. Bioorg Med Chem Lett. 2008 May 15;18(10):3029-33. DMHZT1S RU https://pubmed.ncbi.nlm.nih.gov/18457948 DMP6U3L DI DMP6U3L DMP6U3L DN 5-hexyl-2-(pyridin-4-yloxy)phenol DMP6U3L MI TTVTX4N DMP6U3L MN Bacterial Fatty acid synthetase I (Bact inhA) DMP6U3L MT DTT DMP6U3L MA Inhibitor DMP6U3L RN Synthesis and in vitro antimycobacterial activity of B-ring modified diaryl ether InhA inhibitors. Bioorg Med Chem Lett. 2008 May 15;18(10):3029-33. DMP6U3L RU https://pubmed.ncbi.nlm.nih.gov/18457948 DMNYOV3 DI DMNYOV3 DMNYOV3 DN 5-hexyl-2-(pyrimidin-2-yloxy)phenol DMNYOV3 MI TTVTX4N DMNYOV3 MN Bacterial Fatty acid synthetase I (Bact inhA) DMNYOV3 MT DTT DMNYOV3 MA Inhibitor DMNYOV3 RN Synthesis and in vitro antimycobacterial activity of B-ring modified diaryl ether InhA inhibitors. Bioorg Med Chem Lett. 2008 May 15;18(10):3029-33. DMNYOV3 RU https://pubmed.ncbi.nlm.nih.gov/18457948 DMHNRXT DI DMHNRXT DMHNRXT DN 5-hexyl-2-phenoxyphenol DMHNRXT MI TTVTX4N DMHNRXT MN Bacterial Fatty acid synthetase I (Bact inhA) DMHNRXT MT DTT DMHNRXT MA Inhibitor DMHNRXT RN Synthesis and in vitro antimycobacterial activity of B-ring modified diaryl ether InhA inhibitors. Bioorg Med Chem Lett. 2008 May 15;18(10):3029-33. DMHNRXT RU https://pubmed.ncbi.nlm.nih.gov/18457948 DMCDUO1 DI DMCDUO1 DMCDUO1 DN 5-Hexyl-5-phenyl-imidazolidine-2,4-dione DMCDUO1 MI TTRK8B9 DMCDUO1 MN Sodium channel unspecific (NaC) DMCDUO1 MT DTT DMCDUO1 MA Inhibitor DMCDUO1 RN Comparative molecular field analysis of hydantoin binding to the neuronal voltage-dependent sodium channel. J Med Chem. 1999 May 6;42(9):1537-45. DMCDUO1 RU https://pubmed.ncbi.nlm.nih.gov/10229624 DMCDUO1 DI DMCDUO1 DMCDUO1 DN 5-Hexyl-5-phenyl-imidazolidine-2,4-dione DMCDUO1 MI TTAXZ0K DMCDUO1 MN Voltage-gated sodium channel alpha Nav1.3 (SCN3A) DMCDUO1 MT DTT DMCDUO1 MA Inhibitor DMCDUO1 RN Comparative molecular field analysis of hydantoin binding to the neuronal voltage-dependent sodium channel. J Med Chem. 1999 May 6;42(9):1537-45. DMCDUO1 RU https://pubmed.ncbi.nlm.nih.gov/10229624 DM4S86L DI DM4S86L DM4S86L DN 5-Hexyl-5-phenyl-pyrimidine-2,4,6-trione DM4S86L MI TTLM12X DM4S86L MN Matrix metalloproteinase-2 (MMP-2) DM4S86L MT DTT DM4S86L MA Inhibitor DM4S86L RN Novel 5,5-disubstitutedpyrimidine-2,4,6-triones as selective MMP inhibitors. Bioorg Med Chem Lett. 2001 Apr 23;11(8):969-72. DM4S86L RU https://pubmed.ncbi.nlm.nih.gov/11327602 DM4S86L DI DM4S86L DM4S86L DN 5-Hexyl-5-phenyl-pyrimidine-2,4,6-trione DM4S86L MI TT6X50U DM4S86L MN Matrix metalloproteinase-9 (MMP-9) DM4S86L MT DTT DM4S86L MA Inhibitor DM4S86L RN Novel 5,5-disubstitutedpyrimidine-2,4,6-triones as selective MMP inhibitors. Bioorg Med Chem Lett. 2001 Apr 23;11(8):969-72. DM4S86L RU https://pubmed.ncbi.nlm.nih.gov/11327602 DM98OEQ DI DM98OEQ DM98OEQ DN 5-hydroxy-1H-indole-3-acetic acid DM98OEQ MI TTGTQHC DM98OEQ MN DNA topoisomerase I (TOP1) DM98OEQ MT DTT DM98OEQ MA Binder DM98OEQ RN Comparison of responses of DNA topoisomerase I from Candida albicans and human cells to four new agents which stimulate topoisomerase-dependent DNA nicking. FEMS Microbiol Lett. 1996 May 1;138(2-3):105-11. DM98OEQ RU https://pubmed.ncbi.nlm.nih.gov/9026436 DM5RI4H DI DM5RI4H DM5RI4H DN 5-hydroxy-1-tosyl-1H-pyrrol-2(5H)-one DM5RI4H MI TTHQPL7 DM5RI4H MN Carbonic anhydrase I (CA-I) DM5RI4H MT DTT DM5RI4H MA Inhibitor DM5RI4H RN A novel and one-pot synthesis of new 1-tosyl pyrrol-2-one derivatives and analysis of carbonic anhydrase inhibitory potencies. Bioorg Med Chem. 2010 Jun 15;18(12):4468-74. DM5RI4H RU https://pubmed.ncbi.nlm.nih.gov/20554206 DM5RI4H DI DM5RI4H DM5RI4H DN 5-hydroxy-1-tosyl-1H-pyrrol-2(5H)-one DM5RI4H MI TTANPDJ DM5RI4H MN Carbonic anhydrase II (CA-II) DM5RI4H MT DTT DM5RI4H MA Inhibitor DM5RI4H RN A novel and one-pot synthesis of new 1-tosyl pyrrol-2-one derivatives and analysis of carbonic anhydrase inhibitory potencies. Bioorg Med Chem. 2010 Jun 15;18(12):4468-74. DM5RI4H RU https://pubmed.ncbi.nlm.nih.gov/20554206 DM8KON3 DI DM8KON3 DM8KON3 DN 5-hydroxy-2-(4-aminophenyl)benzofuran DM8KON3 MI TTE4KHA DM8KON3 MN Amyloid beta A4 protein (APP) DM8KON3 MT DTT DM8KON3 MA Inhibitor DM8KON3 RN Novel benzofuran derivatives for PET imaging of beta-amyloid plaques in Alzheimer's disease brains. J Med Chem. 2006 May 4;49(9):2725-30. DM8KON3 RU https://pubmed.ncbi.nlm.nih.gov/16640332 DMYL0ZF DI DMYL0ZF DMYL0ZF DN 5-hydroxy-2-(4-dimethylaminophenyl)benzofuran DMYL0ZF MI TTE4KHA DMYL0ZF MN Amyloid beta A4 protein (APP) DMYL0ZF MT DTT DMYL0ZF MA Inhibitor DMYL0ZF RN Novel benzofuran derivatives for PET imaging of beta-amyloid plaques in Alzheimer's disease brains. J Med Chem. 2006 May 4;49(9):2725-30. DMYL0ZF RU https://pubmed.ncbi.nlm.nih.gov/16640332 DM4QC0R DI DM4QC0R DM4QC0R DN 5-hydroxy-2-(4-methylaminophenyl)benzofuran DM4QC0R MI TTE4KHA DM4QC0R MN Amyloid beta A4 protein (APP) DM4QC0R MT DTT DM4QC0R MA Inhibitor DM4QC0R RN Novel benzofuran derivatives for PET imaging of beta-amyloid plaques in Alzheimer's disease brains. J Med Chem. 2006 May 4;49(9):2725-30. DM4QC0R RU https://pubmed.ncbi.nlm.nih.gov/16640332 DMTO2L3 DI DMTO2L3 DMTO2L3 DN 5-hydroxy-2-(pentylthiomethyl)-4H-pyran-4-one DMTO2L3 MI TTULVH8 DMTO2L3 MN Tyrosinase (TYR) DMTO2L3 MT DTT DMTO2L3 MA Inhibitor DMTO2L3 RN Kojyl thioether derivatives having both tyrosinase inhibitory and anti-inflammatory properties. Bioorg Med Chem Lett. 2010 Nov 15;20(22):6569-71. DMTO2L3 RU https://pubmed.ncbi.nlm.nih.gov/20934336 DM7M1RZ DI DM7M1RZ DM7M1RZ DN 5-hydroxy-2-(propylthiomethyl)-4H-pyran-4-one DM7M1RZ MI TTULVH8 DM7M1RZ MN Tyrosinase (TYR) DM7M1RZ MT DTT DM7M1RZ MA Inhibitor DM7M1RZ RN Kojyl thioether derivatives having both tyrosinase inhibitory and anti-inflammatory properties. Bioorg Med Chem Lett. 2010 Nov 15;20(22):6569-71. DM7M1RZ RU https://pubmed.ncbi.nlm.nih.gov/20934336 DMLZKNF DI DMLZKNF DMLZKNF DN 5-hydroxy-2-phenylisoindoline-1,3-dione DMLZKNF MI TTZAYWL DMLZKNF MN Estrogen receptor (ESR) DMLZKNF MT DTT DMLZKNF MA Inhibitor DMLZKNF RN Estrogen receptor beta ligands: design and synthesis of new 2-phenyl-isoindole-1,3-diones. Bioorg Med Chem Lett. 2007 Jan 1;17(1):118-22. DMLZKNF RU https://pubmed.ncbi.nlm.nih.gov/17049855 DMI0GMB DI DMI0GMB DMI0GMB DN 5-hydroxyindole DMI0GMB MI TTPC4TU DMI0GMB MN 5-HT 3A receptor (HTR3A) DMI0GMB MT DTT DMI0GMB MA Modulator (allosteric modulator) DMI0GMB RN The 5-HT3B subunit confers spontaneous channel opening and altered ligand properties of the 5-HT3 receptor. J Biol Chem. 2008 Mar 14;283(11):6826-31. DMI0GMB RU https://pubmed.ncbi.nlm.nih.gov/18187416 DMDWZGJ DI DMDWZGJ DMDWZGJ DN 5-hydroxy-L-tryptophan DMDWZGJ MI TTUYIZW DMDWZGJ MN Solute carrier family 36 member 1 (SLC36A1) DMDWZGJ MT DTT DMDWZGJ MA Inhibitor DMDWZGJ RN Serotonin, L-tryptophan, and tryptamine are effective inhibitors of the amino acid transport system PAT1. FASEB J. 2005 Sep;19(11):1468-73. DMDWZGJ RU https://pubmed.ncbi.nlm.nih.gov/16126914 DMDWZGJ DI DMDWZGJ DMDWZGJ DN 5-hydroxy-L-tryptophan DMDWZGJ MI TT5U0XA DMDWZGJ MN Solute carrier family 36 member 2 (SLC36A2) DMDWZGJ MT DTT DMDWZGJ MA Inhibitor DMDWZGJ RN Amino acid derivatives are substrates or non-transported inhibitors of the amino acid transporter PAT2 (slc36a2). Biochim Biophys Acta. 2011 Jan;1808(1):260-70. DMDWZGJ RU https://pubmed.ncbi.nlm.nih.gov/20691150 DMT9FQN DI DMT9FQN DMT9FQN DN 5-Hydroxymethyl-3-pyrrol-1-yl-oxazolidin-2-one DMT9FQN MI TT3WG5C DMT9FQN MN Monoamine oxidase type A (MAO-A) DMT9FQN MT DTT DMT9FQN MA Inhibitor DMT9FQN RN 3-(1H-Pyrrol-1-yl)-2-oxazolidinones as reversible, highly potent, and selective inhibitors of monoamine oxidase type A. J Med Chem. 2002 Mar 14;45(6):1180-3. DMT9FQN RU https://pubmed.ncbi.nlm.nih.gov/11881986 DMT9FQN DI DMT9FQN DMT9FQN DN 5-Hydroxymethyl-3-pyrrol-1-yl-oxazolidin-2-one DMT9FQN MI TTGP7BY DMT9FQN MN Monoamine oxidase type B (MAO-B) DMT9FQN MT DTT DMT9FQN MA Inhibitor DMT9FQN RN 3-(1H-Pyrrol-1-yl)-2-oxazolidinones as reversible, highly potent, and selective inhibitors of monoamine oxidase type A. J Med Chem. 2002 Mar 14;45(6):1180-3. DMT9FQN RU https://pubmed.ncbi.nlm.nih.gov/11881986 DMN9FPV DI DMN9FPV DMN9FPV DN 5-hydroxymethylbenzo[b]thiophen-2-ylboronic acid DMN9FPV MI TTHI19T DMN9FPV MN Staphylococcus Beta-lactamase (Stap-coc blaZ) DMN9FPV MT DTT DMN9FPV MA Inhibitor DMN9FPV RN Optimizing cell permeation of an antibiotic resistance inhibitor for improved efficacy. J Med Chem. 2007 Nov 15;50(23):5644-54. DMN9FPV RU https://pubmed.ncbi.nlm.nih.gov/17956081 DMZHVRW DI DMZHVRW DMZHVRW DN 5-Hydroxymethyl-Chonduritol DMZHVRW MI TTCGSZ4 DMZHVRW MN Pancreatic alpha-amylase (AMY2A) DMZHVRW MT DTT DMZHVRW MA Inhibitor DMZHVRW RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMZHVRW RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMWVCJ1 DI DMWVCJ1 DMWVCJ1 DN 5-Hydroxymethyluridine-2'-Deoxy-5'-Monophosphate DMWVCJ1 MI TT5B8AX DMWVCJ1 MN Mycobacterium Thymidine monophosphate kinase (MycB tmk) DMWVCJ1 MT DTT DMWVCJ1 MA Inhibitor DMWVCJ1 RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMWVCJ1 RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMMF57V DI DMMF57V DMMF57V DN 5-hydroxynaphthalene-1-sulfonamide DMMF57V MI TT7HF4W DMMF57V MN Cyclin-dependent kinase 2 (CDK2) DMMF57V MT DTT DMMF57V MA Inhibitor DMMF57V RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DMMF57V RU https://pubmed.ncbi.nlm.nih.gov/10592235 DMJQFZH DI DMJQFZH DMJQFZH DN 5-hydroxy-pentanoate DMJQFZH MI TT6TKEN DMJQFZH MN Gamma-hydroxybutyrate receptor (SLC52A2) DMJQFZH MT DTT DMJQFZH MA Inhibitor DMJQFZH RN Analogues of gamma-hydroxybutyric acid. Synthesis and binding studies. J Med Chem. 1988 May;31(5):893-7. DMJQFZH RU https://pubmed.ncbi.nlm.nih.gov/3361576 DMIXQG6 DI DMIXQG6 DMIXQG6 DN 5-hydroxyvaleric acid DMIXQG6 MI TTJHKYD DMIXQG6 MN Delta-aminolevulinic acid dehydratase (ALAD) DMIXQG6 MT DTT DMIXQG6 MA Inhibitor DMIXQG6 RN Structure of yeast 5-aminolaevulinic acid dehydratase complexed with the inhibitor 5-hydroxylaevulinic acid. Acta Crystallogr D Biol Crystallogr. 2005 Sep;61(Pt 9):1222-6. DMIXQG6 RU https://pubmed.ncbi.nlm.nih.gov/16131755 DMVSBHU DI DMVSBHU DMVSBHU DN 5-Imidazol-1-yl-5,6,7,8-tetrahydro-quinoline DMVSBHU MI TTKNWZ4 DMVSBHU MN Thromboxane-A synthase (TBXAS1) DMVSBHU MT DTT DMVSBHU MA Inhibitor DMVSBHU RN 1-imidazolyl(alkyl)-substituted di- and tetrahydroquinolines and analogues: syntheses and evaluation of dual inhibitors of thromboxane A(2) synthas... J Med Chem. 2000 May 4;43(9):1841-51. DMVSBHU RU https://pubmed.ncbi.nlm.nih.gov/10794700 DMW8AOM DI DMW8AOM DMW8AOM DN 5-Indan-(1E)-ylidenemethyl-1H-imidazole DMW8AOM MI TTSZLWK DMW8AOM MN Aromatase (CYP19A1) DMW8AOM MT DTT DMW8AOM MA Inhibitor DMW8AOM RN Synthesis and evaluation of imidazolylmethylenetetrahydronaphthalenes and imidazolylmethyleneindanes: potent inhibitors of aldosterone synthase. J Med Chem. 2005 Mar 24;48(6):1796-805. DMW8AOM RU https://pubmed.ncbi.nlm.nih.gov/15771425 DMW8AOM DI DMW8AOM DMW8AOM DN 5-Indan-(1E)-ylidenemethyl-1H-imidazole DMW8AOM MI TTIQUX7 DMW8AOM MN Steroid 11-beta-hydroxylase (CYP11B1) DMW8AOM MT DTT DMW8AOM MA Inhibitor DMW8AOM RN Synthesis and evaluation of imidazolylmethylenetetrahydronaphthalenes and imidazolylmethyleneindanes: potent inhibitors of aldosterone synthase. J Med Chem. 2005 Mar 24;48(6):1796-805. DMW8AOM RU https://pubmed.ncbi.nlm.nih.gov/15771425 DMKLY20 DI DMKLY20 DMKLY20 DN 5-Indan-(1Z)-ylidenemethyl-1H-imidazole DMKLY20 MI TTSZLWK DMKLY20 MN Aromatase (CYP19A1) DMKLY20 MT DTT DMKLY20 MA Inhibitor DMKLY20 RN Synthesis and evaluation of imidazolylmethylenetetrahydronaphthalenes and imidazolylmethyleneindanes: potent inhibitors of aldosterone synthase. J Med Chem. 2005 Mar 24;48(6):1796-805. DMKLY20 RU https://pubmed.ncbi.nlm.nih.gov/15771425 DMKLY20 DI DMKLY20 DMKLY20 DN 5-Indan-(1Z)-ylidenemethyl-1H-imidazole DMKLY20 MI TTIQUX7 DMKLY20 MN Steroid 11-beta-hydroxylase (CYP11B1) DMKLY20 MT DTT DMKLY20 MA Inhibitor DMKLY20 RN Synthesis and evaluation of imidazolylmethylenetetrahydronaphthalenes and imidazolylmethyleneindanes: potent inhibitors of aldosterone synthase. J Med Chem. 2005 Mar 24;48(6):1796-805. DMKLY20 RU https://pubmed.ncbi.nlm.nih.gov/15771425 DMDKFIO DI DMDKFIO DMDKFIO DN 5-iodo orotate DMDKFIO MI TT09NOX DMDKFIO MN Plasmodium Dihydroorotase (Malaria dho) DMDKFIO MT DTT DMDKFIO MA Inhibitor DMDKFIO RN Antimalarial activity of orotate analogs that inhibit dihydroorotase and dihydroorotate dehydrogenase. Biochem Pharmacol. 1992 Mar 17;43(6):1295-301. DMDKFIO RU https://pubmed.ncbi.nlm.nih.gov/1348618 DMVT2LW DI DMVT2LW DMVT2LW DN 5-iodo,5'-deoxytubercidin DMVT2LW MI TTL732K DMVT2LW MN Adenosine kinase (ADK) DMVT2LW MT DTT DMVT2LW MA Inhibitor DMVT2LW RN Crystal structures of human adenosine kinase inhibitor complexes reveal two distinct binding modes. J Med Chem. 2006 Nov 16;49(23):6726-31. DMVT2LW RU https://pubmed.ncbi.nlm.nih.gov/17154503 DM4NQY6 DI DM4NQY6 DM4NQY6 DN 5-iodo-1H-indazole DM4NQY6 MI TTZUFI5 DM4NQY6 MN Nitric-oxide synthase brain (NOS1) DM4NQY6 MT DTT DM4NQY6 MA Inhibitor DM4NQY6 RN 4-substituted indazoles as new inhibitors of neuronal nitric oxide synthase. Bioorg Med Chem Lett. 2007 Jun 1;17(11):3177-80. DM4NQY6 RU https://pubmed.ncbi.nlm.nih.gov/17395463 DMZACXG DI DMZACXG DMZACXG DN 5-Iodo-2'-Deoxyuridine-5'-Monophosphate DMZACXG MI TTP3QRF DMZACXG MN Thymidine kinase 1 (TK1) DMZACXG MT DTT DMZACXG MA Inhibitor DMZACXG RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMZACXG RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMQINY5 DI DMQINY5 DMQINY5 DN 5'-iodoresiniferatoxin DMQINY5 MI TTKP2SU DMQINY5 MN Transient receptor potential cation channel V4 (TRPV4) DMQINY5 MT DTT DMQINY5 MA Inhibitor DMQINY5 RN N-4-methansulfonamidobenzyl-N'-2-substituted-4-tert-butyl-benzyl thioureas as potent vanilloid receptor antagonistic ligands. Bioorg Med Chem Lett. 2004 Apr 5;14(7):1693-6. DMQINY5 RU https://pubmed.ncbi.nlm.nih.gov/15026052 DML5ZEJ DI DML5ZEJ DML5ZEJ DN 5'-iodotubercidin DML5ZEJ MI TTL732K DML5ZEJ MN Adenosine kinase (ADK) DML5ZEJ MT DTT DML5ZEJ MA Inhibitor DML5ZEJ RN Inhibition of adenosine kinase attenuates interleukin-1- and lipopolysaccharide-induced alterations in articular cartilage metabolism. Osteoarthritis Cartilage. 2005 Mar;13(3):250-7. DML5ZEJ RU https://pubmed.ncbi.nlm.nih.gov/15727892 DM4O6I5 DI DM4O6I5 DM4O6I5 DN 5-Iodouracil DM4O6I5 MI TTZPS91 DM4O6I5 MN Dihydrothymine dehydrogenase (DPYD) DM4O6I5 MT DTT DM4O6I5 MA Inhibitor DM4O6I5 RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DM4O6I5 RU https://pubmed.ncbi.nlm.nih.gov/17139284 DME6BX5 DI DME6BX5 DME6BX5 DN 5-Isopropyl-1H-pyrazole-3-carboxylic acid DME6BX5 MI TTWNV8U DME6BX5 MN Nicotinic acid receptor (HCAR2) DME6BX5 MT DTT DME6BX5 MA Inhibitor DME6BX5 RN Pyrazole derivatives as partial agonists for the nicotinic acid receptor. J Med Chem. 2003 Aug 28;46(18):3945-51. DME6BX5 RU https://pubmed.ncbi.nlm.nih.gov/12930155 DM2TNWO DI DM2TNWO DM2TNWO DN 5-isopropyl-2-(phenylamino)thiazol-4(5H)-one DM2TNWO MI TTN7BL9 DM2TNWO MN Corticosteroid 11-beta-dehydrogenase 1 (HSD11B1) DM2TNWO MT DTT DM2TNWO MA Inhibitor DM2TNWO RN The discovery of 2-anilinothiazolones as 11beta-HSD1 inhibitors. Bioorg Med Chem Lett. 2007 Nov 15;17(22):6056-61. DM2TNWO RU https://pubmed.ncbi.nlm.nih.gov/17919905 DMXGRMB DI DMXGRMB DMXGRMB DN 5-Isopropyl-3-(2-pyrrolidin-1-yl-ethyl)-1H-indole DMXGRMB MI TTK8CXU DMXGRMB MN 5-HT 1B receptor (HTR1B) DMXGRMB MT DTT DMXGRMB MA Inhibitor DMXGRMB RN 5-Alkyltryptamine derivatives as highly selective and potent 5-HT1D receptor agonists. Bioorg Med Chem Lett. 2000 Aug 7;10(15):1707-9. DMXGRMB RU https://pubmed.ncbi.nlm.nih.gov/10937729 DMXGRMB DI DMXGRMB DMXGRMB DN 5-Isopropyl-3-(2-pyrrolidin-1-yl-ethyl)-1H-indole DMXGRMB MI TT6MSOK DMXGRMB MN 5-HT 1D receptor (HTR1D) DMXGRMB MT DTT DMXGRMB MA Inhibitor DMXGRMB RN 5-Alkyltryptamine derivatives as highly selective and potent 5-HT1D receptor agonists. Bioorg Med Chem Lett. 2000 Aug 7;10(15):1707-9. DMXGRMB RU https://pubmed.ncbi.nlm.nih.gov/10937729 DMXVPL1 DI DMXVPL1 DMXVPL1 DN 5-ketodihydromevinolin DMXVPL1 MI TTPADOQ DMXVPL1 MN HMG-CoA reductase (HMGCR) DMXVPL1 MT DTT DMXVPL1 MA Inhibitor DMXVPL1 RN Total synthesis and biological evaluation of structural analogues of compactin and dihydromevinolin. J Med Chem. 1987 Oct;30(10):1858-73. DMXVPL1 RU https://pubmed.ncbi.nlm.nih.gov/3656359 DMFZN7J DI DMFZN7J DMFZN7J DN 5-Me-IAA DMFZN7J MI TT6XFEU DMFZN7J MN GABA(A) receptor rho1 (GABRR1) DMFZN7J MT DTT DMFZN7J MA Agonist DMFZN7J RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 420). DMFZN7J RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=420 DMFZN7J DI DMFZN7J DMFZN7J DN 5-Me-IAA DMFZN7J MI TTQMXLS DMFZN7J MN GABA(A) receptor rho2 (GABRR2) DMFZN7J MT DTT DMFZN7J MA Agonist DMFZN7J RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 421). DMFZN7J RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=421 DMFZN7J DI DMFZN7J DMFZN7J DN 5-Me-IAA DMFZN7J MI TT4N6D8 DMFZN7J MN GABA(A) receptor rho3 (GABRR3) DMFZN7J MT DTT DMFZN7J MA Agonist DMFZN7J RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 422). DMFZN7J RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=422 DMG0EL7 DI DMG0EL7 DMG0EL7 DN 5-MEO-DMT DMG0EL7 MI TTJQOD7 DMG0EL7 MN 5-HT 2A receptor (HTR2A) DMG0EL7 MT DTT DMG0EL7 MA Inhibitor DMG0EL7 RN 1-((S)-2-aminopropyl)-1H-indazol-6-ol: a potent peripherally acting 5-HT2 receptor agonist with ocular hypotensive activity. J Med Chem. 2006 Jan 12;49(1):318-28. DMG0EL7 RU https://pubmed.ncbi.nlm.nih.gov/16392816 DMG0EL7 DI DMG0EL7 DMG0EL7 DN 5-MEO-DMT DMG0EL7 MI TT0K1SC DMG0EL7 MN 5-HT 2B receptor (HTR2B) DMG0EL7 MT DTT DMG0EL7 MA Inhibitor DMG0EL7 RN 1-((S)-2-aminopropyl)-1H-indazol-6-ol: a potent peripherally acting 5-HT2 receptor agonist with ocular hypotensive activity. J Med Chem. 2006 Jan 12;49(1):318-28. DMG0EL7 RU https://pubmed.ncbi.nlm.nih.gov/16392816 DMG0EL7 DI DMG0EL7 DMG0EL7 DN 5-MEO-DMT DMG0EL7 MI TTWJBZ5 DMG0EL7 MN 5-HT 2C receptor (HTR2C) DMG0EL7 MT DTT DMG0EL7 MA Inhibitor DMG0EL7 RN 1-((S)-2-aminopropyl)-1H-indazol-6-ol: a potent peripherally acting 5-HT2 receptor agonist with ocular hypotensive activity. J Med Chem. 2006 Jan 12;49(1):318-28. DMG0EL7 RU https://pubmed.ncbi.nlm.nih.gov/16392816 DMG0EL7 DI DMG0EL7 DMG0EL7 DN 5-MEO-DMT DMG0EL7 MI TTJS8PY DMG0EL7 MN 5-HT 6 receptor (HTR6) DMG0EL7 MT DTT DMG0EL7 MA Inhibitor DMG0EL7 RN Interaction of N1-unsubstituted and N1-benzenesulfonyltryptamines at h5-HT6 receptors. Bioorg Med Chem Lett. 2006 Nov 15;16(22):5832-5. DMG0EL7 RU https://pubmed.ncbi.nlm.nih.gov/16945532 DMG0EL7 DI DMG0EL7 DMG0EL7 DN 5-MEO-DMT DMG0EL7 MI DECB0K3 DMG0EL7 MN Cytochrome P450 2D6 (CYP2D6) DMG0EL7 MT DME DMG0EL7 MA Metabolism DMG0EL7 RN Psychedelic 5-methoxy-N,N-dimethyltryptamine: metabolism, pharmacokinetics, drug interactions, and pharmacological actions. Curr Drug Metab. 2010 Oct;11(8):659-66. DMG0EL7 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=20942780 DM7YGJO DI DM7YGJO DM7YGJO DN 5-Mercapto-pentanoic acid DM7YGJO MI TT9G4N0 DM7YGJO MN Glutamate carboxypeptidase II (GCPII) DM7YGJO MT DTT DM7YGJO MA Inhibitor DM7YGJO RN Synthesis and biological evaluation of thiol-based inhibitors of glutamate carboxypeptidase II: discovery of an orally active GCP II inhibitor. J Med Chem. 2003 May 8;46(10):1989-96. DM7YGJO RU https://pubmed.ncbi.nlm.nih.gov/12723961 DMET3OJ DI DMET3OJ DMET3OJ DN 5-Mercapto-pentanoic acid phenylamide DMET3OJ MI TTBH0VX DMET3OJ MN Histone deacetylase (HDAC) DMET3OJ MT DTT DMET3OJ MA Inhibitor DMET3OJ RN Novel inhibitors of human histone deacetylases: design, synthesis, enzyme inhibition, and cancer cell growth inhibition of SAHA-based non-hydroxama... J Med Chem. 2005 Feb 24;48(4):1019-32. DMET3OJ RU https://pubmed.ncbi.nlm.nih.gov/15715470 DMET3OJ DI DMET3OJ DMET3OJ DN 5-Mercapto-pentanoic acid phenylamide DMET3OJ MI TT6R7JZ DMET3OJ MN Histone deacetylase 1 (HDAC1) DMET3OJ MT DTT DMET3OJ MA Inhibitor DMET3OJ RN Novel inhibitors of human histone deacetylases: design, synthesis, enzyme inhibition, and cancer cell growth inhibition of SAHA-based non-hydroxama... J Med Chem. 2005 Feb 24;48(4):1019-32. DMET3OJ RU https://pubmed.ncbi.nlm.nih.gov/15715470 DMET3OJ DI DMET3OJ DMET3OJ DN 5-Mercapto-pentanoic acid phenylamide DMET3OJ MI TTYHPU6 DMET3OJ MN Histone deacetylase 10 (HDAC10) DMET3OJ MT DTT DMET3OJ MA Inhibitor DMET3OJ RN Novel inhibitors of human histone deacetylases: design, synthesis, enzyme inhibition, and cancer cell growth inhibition of SAHA-based non-hydroxama... J Med Chem. 2005 Feb 24;48(4):1019-32. DMET3OJ RU https://pubmed.ncbi.nlm.nih.gov/15715470 DMET3OJ DI DMET3OJ DMET3OJ DN 5-Mercapto-pentanoic acid phenylamide DMET3OJ MI TTSHTOI DMET3OJ MN Histone deacetylase 2 (HDAC2) DMET3OJ MT DTT DMET3OJ MA Inhibitor DMET3OJ RN Novel inhibitors of human histone deacetylases: design, synthesis, enzyme inhibition, and cancer cell growth inhibition of SAHA-based non-hydroxama... J Med Chem. 2005 Feb 24;48(4):1019-32. DMET3OJ RU https://pubmed.ncbi.nlm.nih.gov/15715470 DMET3OJ DI DMET3OJ DMET3OJ DN 5-Mercapto-pentanoic acid phenylamide DMET3OJ MI TTTQGH8 DMET3OJ MN Histone deacetylase 4 (HDAC4) DMET3OJ MT DTT DMET3OJ MA Inhibitor DMET3OJ RN Novel inhibitors of human histone deacetylases: design, synthesis, enzyme inhibition, and cancer cell growth inhibition of SAHA-based non-hydroxama... J Med Chem. 2005 Feb 24;48(4):1019-32. DMET3OJ RU https://pubmed.ncbi.nlm.nih.gov/15715470 DMET3OJ DI DMET3OJ DMET3OJ DN 5-Mercapto-pentanoic acid phenylamide DMET3OJ MI TT5ZKDI DMET3OJ MN Histone deacetylase 6 (HDAC6) DMET3OJ MT DTT DMET3OJ MA Inhibitor DMET3OJ RN Novel inhibitors of human histone deacetylases: design, synthesis, enzyme inhibition, and cancer cell growth inhibition of SAHA-based non-hydroxama... J Med Chem. 2005 Feb 24;48(4):1019-32. DMET3OJ RU https://pubmed.ncbi.nlm.nih.gov/15715470 DMET3OJ DI DMET3OJ DMET3OJ DN 5-Mercapto-pentanoic acid phenylamide DMET3OJ MI TTT6LFV DMET3OJ MN Histone deacetylase 8 (HDAC8) DMET3OJ MT DTT DMET3OJ MA Inhibitor DMET3OJ RN Novel inhibitors of human histone deacetylases: design, synthesis, enzyme inhibition, and cancer cell growth inhibition of SAHA-based non-hydroxama... J Med Chem. 2005 Feb 24;48(4):1019-32. DMET3OJ RU https://pubmed.ncbi.nlm.nih.gov/15715470 DMPEKWD DI DMPEKWD DMPEKWD DN 5-Methoxy-1-phenyl-1H-benzoimidazole DMPEKWD MI TT8FYO9 DMPEKWD MN Platelet-derived growth factor receptor alpha (PDGFRA) DMPEKWD MT DTT DMPEKWD MA Inhibitor DMPEKWD RN Structure-activity relationships for 1-phenylbenzimidazoles as selective ATP site inhibitors of the platelet-derived growth factor receptor. J Med Chem. 1998 Dec 31;41(27):5457-65. DMPEKWD RU https://pubmed.ncbi.nlm.nih.gov/9876115 DMPEKWD DI DMPEKWD DMPEKWD DN 5-Methoxy-1-phenyl-1H-benzoimidazole DMPEKWD MI TTI7421 DMPEKWD MN Platelet-derived growth factor receptor beta (PDGFRB) DMPEKWD MT DTT DMPEKWD MA Inhibitor DMPEKWD RN Structure-activity relationships for 1-phenylbenzimidazoles as selective ATP site inhibitors of the platelet-derived growth factor receptor. J Med Chem. 1998 Dec 31;41(27):5457-65. DMPEKWD RU https://pubmed.ncbi.nlm.nih.gov/9876115 DMX1LY3 DI DMX1LY3 DMX1LY3 DN 5-methoxy-2-(2-(pyrrolidin-1-yl)ethyl)-1H-indole DMX1LY3 MI TT9JNIC DMX1LY3 MN Histamine H3 receptor (H3R) DMX1LY3 MT DTT DMX1LY3 MA Inhibitor DMX1LY3 RN In vitro SAR of pyrrolidine-containing histamine H3 receptor antagonists: trends across multiple chemical series. Bioorg Med Chem Lett. 2008 Jan 1;18(1):355-9. DMX1LY3 RU https://pubmed.ncbi.nlm.nih.gov/18077160 DMG2HSU DI DMG2HSU DMG2HSU DN 5-methoxy-2-(4-(methylsulfonyl)phenyl)-1H-indole DMG2HSU MI TTVKILB DMG2HSU MN Prostaglandin G/H synthase 2 (COX-2) DMG2HSU MT DTT DMG2HSU MA Inhibitor DMG2HSU RN Synthesis and biological evaluation of new 4-carboxyl quinoline derivatives as cyclooxygenase-2 inhibitors. Bioorg Med Chem. 2009 Jul 15;17(14):5312-7. DMG2HSU RU https://pubmed.ncbi.nlm.nih.gov/19560931 DMW7IXL DI DMW7IXL DMW7IXL DN 5-methoxy-2-(4-aminophenyl)benzofuran DMW7IXL MI TTE4KHA DMW7IXL MN Amyloid beta A4 protein (APP) DMW7IXL MT DTT DMW7IXL MA Inhibitor DMW7IXL RN Novel benzofuran derivatives for PET imaging of beta-amyloid plaques in Alzheimer's disease brains. J Med Chem. 2006 May 4;49(9):2725-30. DMW7IXL RU https://pubmed.ncbi.nlm.nih.gov/16640332 DM3NUMG DI DM3NUMG DM3NUMG DN 5-methoxy-2-(4-dimethylaminophenyl)benzofuran DM3NUMG MI TTE4KHA DM3NUMG MN Amyloid beta A4 protein (APP) DM3NUMG MT DTT DM3NUMG MA Inhibitor DM3NUMG RN Novel benzofuran derivatives for PET imaging of beta-amyloid plaques in Alzheimer's disease brains. J Med Chem. 2006 May 4;49(9):2725-30. DM3NUMG RU https://pubmed.ncbi.nlm.nih.gov/16640332 DM5N1JX DI DM5N1JX DM5N1JX DN 5-methoxy-2-(4-methylaminophenyl)benzofuran DM5N1JX MI TTE4KHA DM5N1JX MN Amyloid beta A4 protein (APP) DM5N1JX MT DTT DM5N1JX MA Inhibitor DM5N1JX RN Novel benzofuran derivatives for PET imaging of beta-amyloid plaques in Alzheimer's disease brains. J Med Chem. 2006 May 4;49(9):2725-30. DM5N1JX RU https://pubmed.ncbi.nlm.nih.gov/16640332 DMNRSYA DI DMNRSYA DMNRSYA DN 5-Methoxy-2,3,4,9-tetrahydro-1H-beta-carboline DMNRSYA MI TTJQOD7 DMNRSYA MN 5-HT 2A receptor (HTR2A) DMNRSYA MT DTT DMNRSYA MA Inhibitor DMNRSYA RN Binding of beta-carbolines at 5-HT(2) serotonin receptors. Bioorg Med Chem Lett. 2003 Dec 15;13(24):4421-5. DMNRSYA RU https://pubmed.ncbi.nlm.nih.gov/14643338 DMNRSYA DI DMNRSYA DMNRSYA DN 5-Methoxy-2,3,4,9-tetrahydro-1H-beta-carboline DMNRSYA MI TT3WG5C DMNRSYA MN Monoamine oxidase type A (MAO-A) DMNRSYA MT DTT DMNRSYA MA Inhibitor DMNRSYA RN Binding of beta-carbolines at imidazoline I2 receptors: a structure-affinity investigation. Bioorg Med Chem Lett. 2004 Feb 23;14(4):999-1002. DMNRSYA RU https://pubmed.ncbi.nlm.nih.gov/15013009 DMNRSYA DI DMNRSYA DMNRSYA DN 5-Methoxy-2,3,4,9-tetrahydro-1H-beta-carboline DMNRSYA MI TTGP7BY DMNRSYA MN Monoamine oxidase type B (MAO-B) DMNRSYA MT DTT DMNRSYA MA Inhibitor DMNRSYA RN Binding of beta-carbolines at imidazoline I2 receptors: a structure-affinity investigation. Bioorg Med Chem Lett. 2004 Feb 23;14(4):999-1002. DMNRSYA RU https://pubmed.ncbi.nlm.nih.gov/15013009 DMW9D30 DI DMW9D30 DMW9D30 DN 5-Methoxy-3-(2-methoxybenzyl)-2H-chromen-2-one DMW9D30 MI TT6OEDT DMW9D30 MN Cannabinoid receptor 1 (CB1) DMW9D30 MT DTT DMW9D30 MA Inhibitor DMW9D30 RN Synthesis and pharmacological evaluation of coumarin derivatives as cannabinoid receptor antagonists and inverse agonists. Bioorg Med Chem. 2009 Apr 1;17(7):2842-51. DMW9D30 RU https://pubmed.ncbi.nlm.nih.gov/19278853 DMW9D30 DI DMW9D30 DMW9D30 DN 5-Methoxy-3-(2-methoxybenzyl)-2H-chromen-2-one DMW9D30 MI TTMSFAW DMW9D30 MN Cannabinoid receptor 2 (CB2) DMW9D30 MT DTT DMW9D30 MA Inhibitor DMW9D30 RN Synthesis and pharmacological evaluation of coumarin derivatives as cannabinoid receptor antagonists and inverse agonists. Bioorg Med Chem. 2009 Apr 1;17(7):2842-51. DMW9D30 RU https://pubmed.ncbi.nlm.nih.gov/19278853 DMBOMZE DI DMBOMZE DMBOMZE DN 5-Methoxy-4,9-dihydro-3H-beta-carboline DMBOMZE MI TTJQOD7 DMBOMZE MN 5-HT 2A receptor (HTR2A) DMBOMZE MT DTT DMBOMZE MA Inhibitor DMBOMZE RN Binding of beta-carbolines at 5-HT(2) serotonin receptors. Bioorg Med Chem Lett. 2003 Dec 15;13(24):4421-5. DMBOMZE RU https://pubmed.ncbi.nlm.nih.gov/14643338 DMBOMZE DI DMBOMZE DMBOMZE DN 5-Methoxy-4,9-dihydro-3H-beta-carboline DMBOMZE MI TT3WG5C DMBOMZE MN Monoamine oxidase type A (MAO-A) DMBOMZE MT DTT DMBOMZE MA Inhibitor DMBOMZE RN Binding of beta-carbolines at imidazoline I2 receptors: a structure-affinity investigation. Bioorg Med Chem Lett. 2004 Feb 23;14(4):999-1002. DMBOMZE RU https://pubmed.ncbi.nlm.nih.gov/15013009 DMBOMZE DI DMBOMZE DMBOMZE DN 5-Methoxy-4,9-dihydro-3H-beta-carboline DMBOMZE MI TTGP7BY DMBOMZE MN Monoamine oxidase type B (MAO-B) DMBOMZE MT DTT DMBOMZE MA Inhibitor DMBOMZE RN Binding of beta-carbolines at imidazoline I2 receptors: a structure-affinity investigation. Bioorg Med Chem Lett. 2004 Feb 23;14(4):999-1002. DMBOMZE RU https://pubmed.ncbi.nlm.nih.gov/15013009 DMCZSP3 DI DMCZSP3 DMCZSP3 DN 5-methoxycarbonylamino-N-acetyltryptamine DMCZSP3 MI TT0WAIE DMCZSP3 MN Melatonin receptor type 1A (MTNR1A) DMCZSP3 MT DTT DMCZSP3 MA Inhibitor DMCZSP3 RN Design and synthesis of benzofuranic derivatives as new ligands at the melatonin-binding site MT3. Bioorg Med Chem. 2008 May 1;16(9):4954-62. DMCZSP3 RU https://pubmed.ncbi.nlm.nih.gov/18372181 DMCZSP3 DI DMCZSP3 DMCZSP3 DN 5-methoxycarbonylamino-N-acetyltryptamine DMCZSP3 MI TT32JK8 DMCZSP3 MN Melatonin receptor type 1B (MTNR1B) DMCZSP3 MT DTT DMCZSP3 MA Inhibitor DMCZSP3 RN Design and synthesis of benzofuranic derivatives as new ligands at the melatonin-binding site MT3. Bioorg Med Chem. 2008 May 1;16(9):4954-62. DMCZSP3 RU https://pubmed.ncbi.nlm.nih.gov/18372181 DMQX3V9 DI DMQX3V9 DMQX3V9 DN 5-Methoxyflavone DMQX3V9 MI TTKPW01 DMQX3V9 MN Androgen receptor messenger RNA (AR mRNA) DMQX3V9 MT DTT DMQX3V9 MA Inhibitor DMQX3V9 RN Effect of flavonoids on androgen and glucocorticoid receptors based on in vitro reporter gene assay. Bioorg Med Chem Lett. 2009 Aug 15;19(16):4706-10. DMQX3V9 RU https://pubmed.ncbi.nlm.nih.gov/19592245 DMUXTWC DI DMUXTWC DMUXTWC DN 5-methoxy-luzindole DMUXTWC MI TT0WAIE DMUXTWC MN Melatonin receptor type 1A (MTNR1A) DMUXTWC MT DTT DMUXTWC MA Agonist DMUXTWC RN Melatonin receptor antagonists that differentiate between the human Mel1a and Mel1b recombinant subtypes are used to assess the pharmacological profile of the rabbit retina ML1 presynaptic heteroreceptor. Naunyn Schmiedebergs Arch Pharmacol. 1997 Mar;355(3):365-75. DMUXTWC RU https://pubmed.ncbi.nlm.nih.gov/9089668 DMJ1HX2 DI DMJ1HX2 DMJ1HX2 DN 5-Methoxymethyl-3-pyrrol-1-yl-oxazolidin-2-one DMJ1HX2 MI TT3WG5C DMJ1HX2 MN Monoamine oxidase type A (MAO-A) DMJ1HX2 MT DTT DMJ1HX2 MA Inhibitor DMJ1HX2 RN 3-(1H-Pyrrol-1-yl)-2-oxazolidinones as reversible, highly potent, and selective inhibitors of monoamine oxidase type A. J Med Chem. 2002 Mar 14;45(6):1180-3. DMJ1HX2 RU https://pubmed.ncbi.nlm.nih.gov/11881986 DM98EQX DI DM98EQX DM98EQX DN 5-Methoxy-N-phenylbenzo[d]oxazol-2-amine DM98EQX MI TT2J34L DM98EQX MN Arachidonate 5-lipoxygenase (5-LOX) DM98EQX MT DTT DM98EQX MA Inhibitor DM98EQX RN Synthesis and evaluation of benzoxazole derivatives as 5-lipoxygenase inhibitors. Bioorg Med Chem. 2010 Nov 1;18(21):7580-5. DM98EQX RU https://pubmed.ncbi.nlm.nih.gov/20870413 DMARCKD DI DMARCKD DMARCKD DN 5-METHOXYTRYPTAMINE DMARCKD MI TTJQOD7 DMARCKD MN 5-HT 2A receptor (HTR2A) DMARCKD MT DTT DMARCKD MA Inhibitor DMARCKD RN Central serotonin receptors as targets for drug research. J Med Chem. 1987 Jan;30(1):1-12. DMARCKD RU https://pubmed.ncbi.nlm.nih.gov/3543362 DMARCKD DI DMARCKD DMARCKD DN 5-METHOXYTRYPTAMINE DMARCKD MI TTJS8PY DMARCKD MN 5-HT 6 receptor (HTR6) DMARCKD MT DTT DMARCKD MA Inhibitor DMARCKD RN Medicinal chemistry driven approaches toward novel and selective serotonin 5-HT6 receptor ligands. J Med Chem. 2005 Mar 24;48(6):1781-95. DMARCKD RU https://pubmed.ncbi.nlm.nih.gov/15771424 DMARCKD DI DMARCKD DMARCKD DN 5-METHOXYTRYPTAMINE DMARCKD MI TTXDKTO DMARCKD MN Long transient receptor potential channel 8 (TRPM8) DMARCKD MT DTT DMARCKD MA Inhibitor DMARCKD RN 5-benzyloxytryptamine as an antagonist of TRPM8. Bioorg Med Chem Lett. 2010 Dec 1;20(23):7076-9. DMARCKD RU https://pubmed.ncbi.nlm.nih.gov/20965726 DM0AIOW DI DM0AIOW DM0AIOW DN 5-methyl nicotinic acid DM0AIOW MI TTWNV8U DM0AIOW MN Nicotinic acid receptor (HCAR2) DM0AIOW MT DTT DM0AIOW MA Agonist DM0AIOW RN Molecular identification of high and low affinity receptors for nicotinic acid. J Biol Chem. 2003 Mar 14;278(11):9869-74. DM0AIOW RU https://pubmed.ncbi.nlm.nih.gov/12522134 DMYNFIP DI DMYNFIP DMYNFIP DN 5-methyl orotate DMYNFIP MI TT09NOX DMYNFIP MN Plasmodium Dihydroorotase (Malaria dho) DMYNFIP MT DTT DMYNFIP MA Inhibitor DMYNFIP RN Antimalarial activity of orotate analogs that inhibit dihydroorotase and dihydroorotate dehydrogenase. Biochem Pharmacol. 1992 Mar 17;43(6):1295-301. DMYNFIP RU https://pubmed.ncbi.nlm.nih.gov/1348618 DM0E1Y9 DI DM0E1Y9 DM0E1Y9 DN 5-Methyl-1,3-dihydro-imidazo[4,5-b]quinolin-2-one DM0E1Y9 MI TT06AWU DM0E1Y9 MN Phosphodiesterase 3A (PDE3A) DM0E1Y9 MT DTT DM0E1Y9 MA Inhibitor DM0E1Y9 RN 1,3-Dihydro-2H-imidazo[4,5-b]quinolin-2-ones--inhibitors of blood platelet cAMP phosphodiesterase and induced aggregation. J Med Chem. 1991 Sep;34(9):2906-16. DM0E1Y9 RU https://pubmed.ncbi.nlm.nih.gov/1654430 DMC10HG DI DMC10HG DMC10HG DN 5-methyl-2-(phenylsulfonamido)benzoic acid DMC10HG MI TTZL0OI DMC10HG MN Methionine aminopeptidase 2 (METAP2) DMC10HG MT DTT DMC10HG MA Inhibitor DMC10HG RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DMC10HG RU https://pubmed.ncbi.nlm.nih.gov/10592235 DMAR4ZF DI DMAR4ZF DMAR4ZF DN 5-methyl-2-(pyridin-2-yl)-1H-benzo[d]imidazole DMAR4ZF MI TTZL0OI DMAR4ZF MN Methionine aminopeptidase 2 (METAP2) DMAR4ZF MT DTT DMAR4ZF MA Inhibitor DMAR4ZF RN Subtype-selectivity of metal-dependent methionine aminopeptidase inhibitors, Bioorg. Med. Chem. Lett. 20(14):4038-4044 (2010). DMAR4ZF RU http://www.sciencedirect.com/science/article/pii/S0960894X10007468 DMH1IVN DI DMH1IVN DMH1IVN DN 5-Methyl-2-m-tolyl-1H-[1,8]naphthyridin-4-one DMH1IVN MI TTML2WA DMH1IVN MN Tubulin (TUB) DMH1IVN MT DTT DMH1IVN MA Inhibitor DMH1IVN RN Antitumor agents. 178. Synthesis and biological evaluation of substituted 2-aryl-1,8-naphthyridin-4(1H)-ones as antitumor agents that inhibit tubul... J Med Chem. 1997 Sep 12;40(19):3049-56. DMH1IVN RU https://pubmed.ncbi.nlm.nih.gov/9301667 DMH1IVN DI DMH1IVN DMH1IVN DN 5-Methyl-2-m-tolyl-1H-[1,8]naphthyridin-4-one DMH1IVN MI TTYFKSZ DMH1IVN MN Tubulin beta (TUBB) DMH1IVN MT DTT DMH1IVN MA Inhibitor DMH1IVN RN Antitumor agents. 178. Synthesis and biological evaluation of substituted 2-aryl-1,8-naphthyridin-4(1H)-ones as antitumor agents that inhibit tubul... J Med Chem. 1997 Sep 12;40(19):3049-56. DMH1IVN RU https://pubmed.ncbi.nlm.nih.gov/9301667 DMIE9BG DI DMIE9BG DMIE9BG DN 5-Methyl-2-p-tolyl-thiazol-4-ol DMIE9BG MI TT2J34L DMIE9BG MN Arachidonate 5-lipoxygenase (5-LOX) DMIE9BG MT DTT DMIE9BG MA Inhibitor DMIE9BG RN 4-hydroxythiazole inhibitors of 5-lipoxygenase. J Med Chem. 1991 Jul;34(7):2158-65. DMIE9BG RU https://pubmed.ncbi.nlm.nih.gov/2066989 DM0G2N5 DI DM0G2N5 DM0G2N5 DN 5-Methyl-3,4-diphenyl-isoxazole DM0G2N5 MI TT8NGED DM0G2N5 MN Prostaglandin G/H synthase 1 (COX-1) DM0G2N5 MT DTT DM0G2N5 MA Inhibitor DM0G2N5 RN Novel synthesis of 3,4-diarylisoxazole analogues of valdecoxib: reversal cyclooxygenase-2 selectivity by sulfonamide group removal. J Med Chem. 2004 Sep 23;47(20):4881-90. DM0G2N5 RU https://pubmed.ncbi.nlm.nih.gov/15369392 DM0G2N5 DI DM0G2N5 DM0G2N5 DN 5-Methyl-3,4-diphenyl-isoxazole DM0G2N5 MI TTVKILB DM0G2N5 MN Prostaglandin G/H synthase 2 (COX-2) DM0G2N5 MT DTT DM0G2N5 MA Inhibitor DM0G2N5 RN Novel synthesis of 3,4-diarylisoxazole analogues of valdecoxib: reversal cyclooxygenase-2 selectivity by sulfonamide group removal. J Med Chem. 2004 Sep 23;47(20):4881-90. DM0G2N5 RU https://pubmed.ncbi.nlm.nih.gov/15369392 DMF0IJ2 DI DMF0IJ2 DMF0IJ2 DN 5-methyl-3-phenylethynyl[1,2,4]triazine DMF0IJ2 MI TTHS256 DMF0IJ2 MN Metabotropic glutamate receptor 5 (mGluR5) DMF0IJ2 MT DTT DMF0IJ2 MA Inhibitor DMF0IJ2 RN Synthesis and pharmacological evaluation of phenylethynyl[1,2,4]methyltriazines as analogues of 3-methyl-6-(phenylethynyl)pyridine. J Med Chem. 2007 Jul 12;50(14):3388-91. DMF0IJ2 RU https://pubmed.ncbi.nlm.nih.gov/17569516 DM6DEOC DI DM6DEOC DM6DEOC DN 5-Methyl-4-propyl-pyrrolidin-(2Z)-ylideneamine DM6DEOC MI TTF10I9 DM6DEOC MN Nitric-oxide synthase inducible (NOS2) DM6DEOC MT DTT DM6DEOC MA Inhibitor DM6DEOC RN Evaluation of pyrrolidin-2-imines and 1,3-thiazolidin-2-imines as inhibitors of nitric oxide synthase. Bioorg Med Chem Lett. 2004 Sep 6;14(17):4539-44. DM6DEOC RU https://pubmed.ncbi.nlm.nih.gov/15357988 DMO37W4 DI DMO37W4 DMO37W4 DN 5-methyl-5-(5-methylthiophen-3-yl)-4-oxo-4,5-dihydrofuran-2-carboxylic acid DMO37W4 MI TT8WFXV DMO37W4 MN Hydroxycarboxylic acid receptor 3 (HCAR3) DMO37W4 MT DTT DMO37W4 MA Agonist DMO37W4 RN Analogues of acifran: agonists of the high and low affinity niacin receptors, GPR109a and GPR109b. J Med Chem. 2007 Apr 5;50(7):1445-8. DMO37W4 RU https://pubmed.ncbi.nlm.nih.gov/17358052 DMRMKXD DI DMRMKXD DMRMKXD DN 5-Methyl-5-phenyl-pyrimidine-2,4,6-trione DMRMKXD MI TT6X50U DMRMKXD MN Matrix metalloproteinase-9 (MMP-9) DMRMKXD MT DTT DMRMKXD MA Inhibitor DMRMKXD RN Novel 5,5-disubstitutedpyrimidine-2,4,6-triones as selective MMP inhibitors. Bioorg Med Chem Lett. 2001 Apr 23;11(8):969-72. DMRMKXD RU https://pubmed.ncbi.nlm.nih.gov/11327602 DMLJVB7 DI DMLJVB7 DMLJVB7 DN 5-methyl-benzo[b]thiophen-2-ylboronic acid DMLJVB7 MI TTHI19T DMLJVB7 MN Staphylococcus Beta-lactamase (Stap-coc blaZ) DMLJVB7 MT DTT DMLJVB7 MA Inhibitor DMLJVB7 RN Optimizing cell permeation of an antibiotic resistance inhibitor for improved efficacy. J Med Chem. 2007 Nov 15;50(23):5644-54. DMLJVB7 RU https://pubmed.ncbi.nlm.nih.gov/17956081 DMRC8SO DI DMRC8SO DMRC8SO DN 5-methyl-cyclosal-d4TMP DMRC8SO MI TTEB0GD DMRC8SO MN Cholinesterase (BCHE) DMRC8SO MT DTT DMRC8SO MA Inhibitor DMRC8SO RN Bis-cycloSal-d4T-monophosphates: drugs that deliver two molecules of bioactive nucleotides. J Med Chem. 2007 Mar 22;50(6):1335-46. DMRC8SO RU https://pubmed.ncbi.nlm.nih.gov/17328534 DMIQ1X3 DI DMIQ1X3 DMIQ1X3 DN 5-methylenearisteromycin DMIQ1X3 MI TTE2KUJ DMIQ1X3 MN Adenosylhomocysteinase (AHCY) DMIQ1X3 MT DTT DMIQ1X3 MA Inhibitor DMIQ1X3 RN Synthesis of 2-modified aristeromycins and their analogs as potent inhibitors against Plasmodium falciparum S-adenosyl-L-homocysteine hydrolase. Bioorg Med Chem. 2008 Apr 1;16(7):3809-15. DMIQ1X3 RU https://pubmed.ncbi.nlm.nih.gov/18295495 DMNJ0XZ DI DMNJ0XZ DMNJ0XZ DN 5-Methyl-N-phenylbenzo[d]oxazol-2-amine DMNJ0XZ MI TT2J34L DMNJ0XZ MN Arachidonate 5-lipoxygenase (5-LOX) DMNJ0XZ MT DTT DMNJ0XZ MA Inhibitor DMNJ0XZ RN Synthesis and evaluation of benzoxazole derivatives as 5-lipoxygenase inhibitors. Bioorg Med Chem. 2010 Nov 1;18(21):7580-5. DMNJ0XZ RU https://pubmed.ncbi.nlm.nih.gov/20870413 DMBQS31 DI DMBQS31 DMBQS31 DN 5-Methyl-oxazolidin-(2Z)-ylideneamine DMBQS31 MI TTZUFI5 DMBQS31 MN Nitric-oxide synthase brain (NOS1) DMBQS31 MT DTT DMBQS31 MA Inhibitor DMBQS31 RN 4,5-Disubstituted-1,3-oxazolidin-2-imine derivatives: a new class of orally bioavailable nitric oxide synthase inhibitor. Bioorg Med Chem Lett. 2004 Jan 19;14(2):313-6. DMBQS31 RU https://pubmed.ncbi.nlm.nih.gov/14698148 DMBQS31 DI DMBQS31 DMBQS31 DN 5-Methyl-oxazolidin-(2Z)-ylideneamine DMBQS31 MI TTF10I9 DMBQS31 MN Nitric-oxide synthase inducible (NOS2) DMBQS31 MT DTT DMBQS31 MA Inhibitor DMBQS31 RN 4,5-Disubstituted-1,3-oxazolidin-2-imine derivatives: a new class of orally bioavailable nitric oxide synthase inhibitor. Bioorg Med Chem Lett. 2004 Jan 19;14(2):313-6. DMBQS31 RU https://pubmed.ncbi.nlm.nih.gov/14698148 DM4QB3G DI DM4QB3G DM4QB3G DN 5-Methyl-pyrrolidin-(2Z)-ylideneamine DM4QB3G MI TTZUFI5 DM4QB3G MN Nitric-oxide synthase brain (NOS1) DM4QB3G MT DTT DM4QB3G MA Inhibitor DM4QB3G RN Evaluation of pyrrolidin-2-imines and 1,3-thiazolidin-2-imines as inhibitors of nitric oxide synthase. Bioorg Med Chem Lett. 2004 Sep 6;14(17):4539-44. DM4QB3G RU https://pubmed.ncbi.nlm.nih.gov/15357988 DM4QB3G DI DM4QB3G DM4QB3G DN 5-Methyl-pyrrolidin-(2Z)-ylideneamine DM4QB3G MI TTCM4B3 DM4QB3G MN Nitric-oxide synthase endothelial (NOS3) DM4QB3G MT DTT DM4QB3G MA Inhibitor DM4QB3G RN Evaluation of pyrrolidin-2-imines and 1,3-thiazolidin-2-imines as inhibitors of nitric oxide synthase. Bioorg Med Chem Lett. 2004 Sep 6;14(17):4539-44. DM4QB3G RU https://pubmed.ncbi.nlm.nih.gov/15357988 DM4QB3G DI DM4QB3G DM4QB3G DN 5-Methyl-pyrrolidin-(2Z)-ylideneamine DM4QB3G MI TTF10I9 DM4QB3G MN Nitric-oxide synthase inducible (NOS2) DM4QB3G MT DTT DM4QB3G MA Inhibitor DM4QB3G RN Evaluation of pyrrolidin-2-imines and 1,3-thiazolidin-2-imines as inhibitors of nitric oxide synthase. Bioorg Med Chem Lett. 2004 Sep 6;14(17):4539-44. DM4QB3G RU https://pubmed.ncbi.nlm.nih.gov/15357988 DMYERNM DI DMYERNM DMYERNM DN 5-methylpyrrolo[3,4-c]carbazole-1,3(2H,6H)-dione DMYERNM MI TTVDSZ0 DMYERNM MN Poly [ADP-ribose] polymerase 1 (PARP1) DMYERNM MT DTT DMYERNM MA Inhibitor DMYERNM RN Synthesis and structure-activity relationships of novel poly(ADP-ribose) polymerase-1 inhibitors. Bioorg Med Chem Lett. 2006 Feb 15;16(4):938-42. DMYERNM RU https://pubmed.ncbi.nlm.nih.gov/16290935 DM3MVSD DI DM3MVSD DM3MVSD DN 5-Methylsulfanyl-thiophene-2-carboxamidine DM3MVSD MI TTGY7WI DM3MVSD MN Urokinase-type plasminogen activator (PLAU) DM3MVSD MT DTT DM3MVSD MA Inhibitor DM3MVSD RN Design and synthesis of 4,5-disubstituted-thiophene-2-amidines as potent urokinase inhibitors. Bioorg Med Chem Lett. 2002 Feb 11;12(3):491-5. DM3MVSD RU https://pubmed.ncbi.nlm.nih.gov/11814826 DM3LY0Q DI DM3LY0Q DM3LY0Q DN 5'-Methylthio-ImmH DM3LY0Q MI TTMCF1Y DM3LY0Q MN Purine nucleoside phosphorylase (PNP) DM3LY0Q MT DTT DM3LY0Q MA Inhibitor DM3LY0Q RN Immucillins in custom catalytic-site cavities. Bioorg Med Chem Lett. 2008 Nov 15;18(22):5900-3. DM3LY0Q RU https://pubmed.ncbi.nlm.nih.gov/18778937 DMK52UH DI DMK52UH DMK52UH DN 5'-methylthio-immucillin-H DMK52UH MI TTMCF1Y DMK52UH MN Purine nucleoside phosphorylase (PNP) DMK52UH MT DTT DMK52UH MA Inhibitor DMK52UH RN Exploring new inhibitors of Plasmodium falciparum purine nucleoside phosphorylase. Eur J Med Chem. 2010 Nov;45(11):5140-9. DMK52UH RU https://pubmed.ncbi.nlm.nih.gov/20817362 DMCX9WN DI DMCX9WN DMCX9WN DN 5-methylurapidil DMCX9WN MI TTBRKXS DMCX9WN MN Adrenergic receptor alpha-1B (ADRA1B) DMCX9WN MT DTT DMCX9WN MA Antagonist DMCX9WN RN Affinity of serotonin receptor antagonists and agonists to recombinant and native alpha1-adrenoceptor subtypes. Jpn J Pharmacol. 2001 Jun;86(2):189-95. DMCX9WN RU https://pubmed.ncbi.nlm.nih.gov/11459121 DMCX9WN DI DMCX9WN DMCX9WN DN 5-methylurapidil DMCX9WN MI TT2NUT5 DMCX9WN MN Adrenergic receptor alpha-2C (ADRA2C) DMCX9WN MT DTT DMCX9WN MA Antagonist DMCX9WN RN Phe-308 and Phe-312 in transmembrane domain 7 are major sites of alpha 1-adrenergic receptor antagonist binding. Imidazoline agonists bind like ant... J Biol Chem. 2001 Jul 6;276(27):25366-71. DMCX9WN RU https://pubmed.ncbi.nlm.nih.gov/11331292 DMX0EAK DI DMX0EAK DMX0EAK DN 5--Monophosphate-9-Beta-D-Ribofuranosyl Xanthine DMX0EAK MI TTBL49X DMX0EAK MN Plasmodium Hypoxanthine-guanine phosphoribosyltransferase (Malaria LACZ) DMX0EAK MT DTT DMX0EAK MA Inhibitor DMX0EAK RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMX0EAK RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMSRGTI DI DMSRGTI DMSRGTI DN 5-MPEP DMSRGTI MI TTHS256 DMSRGTI MN Metabotropic glutamate receptor 5 (mGluR5) DMSRGTI MT DTT DMSRGTI MA Modulator (allosteric modulator) DMSRGTI RN A close structural analog of 2-methyl-6-(phenylethynyl)-pyridine acts as a neutral allosteric site ligand on metabotropic glutamate receptor subtyp... Mol Pharmacol. 2005 Dec;68(6):1793-802. DMSRGTI RU https://pubmed.ncbi.nlm.nih.gov/16155210 DMOSKJ8 DI DMOSKJ8 DMOSKJ8 DN 5-N-Allyl-Arginine DMOSKJ8 MI TTZUFI5 DMOSKJ8 MN Nitric-oxide synthase brain (NOS1) DMOSKJ8 MT DTT DMOSKJ8 MA Inhibitor DMOSKJ8 RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMOSKJ8 RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMK0PAL DI DMK0PAL DMK0PAL DN 5-Naphthalen-2-yl-1H-imidazole DMK0PAL MI TTIQUX7 DMK0PAL MN Steroid 11-beta-hydroxylase (CYP11B1) DMK0PAL MT DTT DMK0PAL MA Inhibitor DMK0PAL RN Heteroaryl-substituted naphthalenes and structurally modified derivatives: selective inhibitors of CYP11B2 for the treatment of congestive heart fa... J Med Chem. 2005 Oct 20;48(21):6632-42. DMK0PAL RU https://pubmed.ncbi.nlm.nih.gov/16220979 DMTH3BW DI DMTH3BW DMTH3BW DN 5-Naphthalen-2-yl-oxazole DMTH3BW MI TTIQUX7 DMTH3BW MN Steroid 11-beta-hydroxylase (CYP11B1) DMTH3BW MT DTT DMTH3BW MA Inhibitor DMTH3BW RN Heteroaryl-substituted naphthalenes and structurally modified derivatives: selective inhibitors of CYP11B2 for the treatment of congestive heart fa... J Med Chem. 2005 Oct 20;48(21):6632-42. DMTH3BW RU https://pubmed.ncbi.nlm.nih.gov/16220979 DMTS06Z DI DMTS06Z DMTS06Z DN 5-Nitro-1H-indole-2,3-dione DMTS06Z MI TTSFWA7 DMTS06Z MN Plasmodium CDK Pfmrk (Malaria Pfmrk) DMTS06Z MT DTT DMTS06Z MA Inhibitor DMTS06Z RN A three-dimensional in silico pharmacophore model for inhibition of Plasmodium falciparum cyclin-dependent kinases and discovery of different class... J Med Chem. 2004 Oct 21;47(22):5418-26. DMTS06Z RU https://pubmed.ncbi.nlm.nih.gov/15481979 DM26MIC DI DM26MIC DM26MIC DN 5-Nitro-2-(4-phenoxy-phenyl)-1H-benzoimidazole DM26MIC MI TT9ABMF DM26MIC MN Serine/threonine-protein kinase Chk2 (RAD53) DM26MIC MT DTT DM26MIC MA Inhibitor DM26MIC RN Checkpoint kinase inhibitors: SAR and radioprotective properties of a series of 2-arylbenzimidazoles. J Med Chem. 2005 Mar 24;48(6):1873-85. DM26MIC RU https://pubmed.ncbi.nlm.nih.gov/15771432 DMH7SIX DI DMH7SIX DMH7SIX DN 5-Nitroindazole DMH7SIX MI TTCM4B3 DMH7SIX MN Nitric-oxide synthase endothelial (NOS3) DMH7SIX MT DTT DMH7SIX MA Inhibitor DMH7SIX RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMH7SIX RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMH7SIX DI DMH7SIX DMH7SIX DN 5-Nitroindazole DMH7SIX MI TTF10I9 DMH7SIX MN Nitric-oxide synthase inducible (NOS2) DMH7SIX MT DTT DMH7SIX MA Inhibitor DMH7SIX RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMH7SIX RU https://pubmed.ncbi.nlm.nih.gov/17139284 DM4K8N2 DI DM4K8N2 DM4K8N2 DN 5-nitroindirubin-3'-oxime DM4K8N2 MI TT7HF4W DM4K8N2 MN Cyclin-dependent kinase 2 (CDK2) DM4K8N2 MT DTT DM4K8N2 MA Inhibitor DM4K8N2 RN 5,5'-substituted indirubin-3'-oxime derivatives as potent cyclin-dependent kinase inhibitors with anticancer activity. J Med Chem. 2010 May 13;53(9):3696-706. DM4K8N2 RU https://pubmed.ncbi.nlm.nih.gov/20361800 DM4K8N2 DI DM4K8N2 DM4K8N2 DN 5-nitroindirubin-3'-oxime DM4K8N2 MI TTCEJ4F DM4K8N2 MN G1/S-specific cyclin-E1 (CCNE1) DM4K8N2 MT DTT DM4K8N2 MA Inhibitor DM4K8N2 RN 5,5'-substituted indirubin-3'-oxime derivatives as potent cyclin-dependent kinase inhibitors with anticancer activity. J Med Chem. 2010 May 13;53(9):3696-706. DM4K8N2 RU https://pubmed.ncbi.nlm.nih.gov/20361800 DM2DWUQ DI DM2DWUQ DM2DWUQ DN 5-Nonyl-5-phenyl-imidazolidine-2,4-dione DM2DWUQ MI TTRK8B9 DM2DWUQ MN Sodium channel unspecific (NaC) DM2DWUQ MT DTT DM2DWUQ MA Inhibitor DM2DWUQ RN Comparative molecular field analysis of hydantoin binding to the neuronal voltage-dependent sodium channel. J Med Chem. 1999 May 6;42(9):1537-45. DM2DWUQ RU https://pubmed.ncbi.nlm.nih.gov/10229624 DM2DWUQ DI DM2DWUQ DM2DWUQ DN 5-Nonyl-5-phenyl-imidazolidine-2,4-dione DM2DWUQ MI TTAXZ0K DM2DWUQ MN Voltage-gated sodium channel alpha Nav1.3 (SCN3A) DM2DWUQ MT DTT DM2DWUQ MA Inhibitor DM2DWUQ RN Comparative molecular field analysis of hydantoin binding to the neuronal voltage-dependent sodium channel. J Med Chem. 1999 May 6;42(9):1537-45. DM2DWUQ RU https://pubmed.ncbi.nlm.nih.gov/10229624 DM74JL8 DI DM74JL8 DM74JL8 DN 5-n-undecyl-6-hydroxy-4,7-dioxobenzothiazole DM74JL8 MI TTRAMF0 DM74JL8 MN Plasmodium Cytochrome B (Malaria MT-CYB) DM74JL8 MT DTT DM74JL8 MA Inhibitor DM74JL8 RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DM74JL8 RU https://pubmed.ncbi.nlm.nih.gov/10592235 DM20X8C DI DM20X8C DM20X8C DN 5'-O-[(L-Methionyl)-Sulphamoyl]Adenosine DM20X8C MI TTOJ46K DM20X8C MN Streptococcus Methionyl-tRNA synthetase (Stre-coc metG) DM20X8C MT DTT DM20X8C MA Inhibitor DM20X8C RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DM20X8C RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMAXHEU DI DMAXHEU DMAXHEU DN 5-octyl-2-phenoxyphenol DMAXHEU MI TTVTX4N DMAXHEU MN Bacterial Fatty acid synthetase I (Bact inhA) DMAXHEU MT DTT DMAXHEU MA Inhibitor DMAXHEU RN Natural products, small molecules, and genetics in tuberculosis drug development. J Med Chem. 2008 May 8;51(9):2606-12. DMAXHEU RU https://pubmed.ncbi.nlm.nih.gov/18393405 DMZT6JR DI DMZT6JR DMZT6JR DN 5-OH-DPAT DMZT6JR MI TTK8CXU DMZT6JR MN 5-HT 1B receptor (HTR1B) DMZT6JR MT DTT DMZT6JR MA Antagonist DMZT6JR RN Mouse 5HT1B serotonin receptor: cloning, functional expression, and localization in motor control centers. Proc Natl Acad Sci U S A. 1992 Apr 1;89(7):3020-4. DMZT6JR RU https://pubmed.ncbi.nlm.nih.gov/1557407 DMZT6JR DI DMZT6JR DMZT6JR DN 5-OH-DPAT DMZT6JR MI TTEX248 DMZT6JR MN Dopamine D2 receptor (D2R) DMZT6JR MT DTT DMZT6JR MA Inhibitor DMZT6JR RN Development of (S)-N6-(2-(4-(isoquinolin-1-yl)piperazin-1-yl)ethyl)-N6-propyl-4,5,6,7-tetrahydrobenzo[d]-thiazole-2,6-diamine and its analogue as a... J Med Chem. 2010 Feb 11;53(3):1023-37. DMZT6JR RU https://pubmed.ncbi.nlm.nih.gov/20038106 DMZT6JR DI DMZT6JR DMZT6JR DN 5-OH-DPAT DMZT6JR MI TT4C8EA DMZT6JR MN Dopamine D3 receptor (D3R) DMZT6JR MT DTT DMZT6JR MA Inhibitor DMZT6JR RN Development of (S)-N6-(2-(4-(isoquinolin-1-yl)piperazin-1-yl)ethyl)-N6-propyl-4,5,6,7-tetrahydrobenzo[d]-thiazole-2,6-diamine and its analogue as a... J Med Chem. 2010 Feb 11;53(3):1023-37. DMZT6JR RU https://pubmed.ncbi.nlm.nih.gov/20038106 DME62OQ DI DME62OQ DME62OQ DN 5-oxo-1-2-4-oxadiazol biphenyl DME62OQ MI TT8DBY3 DME62OQ MN Angiotensin II receptor type-1 (AGTR1) DME62OQ MT DTT DME62OQ MA Antagonist DME62OQ RN Synthesis and biological evaluation of novel potent angiotensin II receptor antagonists with anti-hypertension effect. Bioorg Med Chem. 2012 Apr 15;20(8):2747-61. DME62OQ RU https://pubmed.ncbi.nlm.nih.gov/22410249 DMLABR9 DI DMLABR9 DMLABR9 DN 5-oxo-12-HETE DMLABR9 MI TT7WBSV DMLABR9 MN Oxoeicosanoid receptor 1 (OXER1) DMLABR9 MT DTT DMLABR9 MA Antagonist DMLABR9 RN Biological inactivation of 5-oxo-6,8,11,14-eicosatetraenoic acid by human platelets. Blood. 1999 Feb 1;93(3):1086-96. DMLABR9 RU https://pubmed.ncbi.nlm.nih.gov/9920859 DM9ZC7B DI DM9ZC7B DM9ZC7B DN 5-oxo-15-HETE DM9ZC7B MI TT7WBSV DM9ZC7B MN Oxoeicosanoid receptor 1 (OXER1) DM9ZC7B MT DTT DM9ZC7B MA Agonist DM9ZC7B RN Metabolism and biologic effects of 5-oxoeicosanoids on human neutrophils. J Immunol. 1996 Jan 1;156(1):336-42. DM9ZC7B RU https://pubmed.ncbi.nlm.nih.gov/8598482 DMQ94BX DI DMQ94BX DMQ94BX DN 5-oxo-1-tosyl-2,5-dihydro-1Hpyrrol-2-yl acetate DMQ94BX MI TTHQPL7 DMQ94BX MN Carbonic anhydrase I (CA-I) DMQ94BX MT DTT DMQ94BX MA Inhibitor DMQ94BX RN A novel and one-pot synthesis of new 1-tosyl pyrrol-2-one derivatives and analysis of carbonic anhydrase inhibitory potencies. Bioorg Med Chem. 2010 Jun 15;18(12):4468-74. DMQ94BX RU https://pubmed.ncbi.nlm.nih.gov/20554206 DM493GU DI DM493GU DM493GU DN 5-oxo-20-HETE DM493GU MI TT7WBSV DM493GU MN Oxoeicosanoid receptor 1 (OXER1) DM493GU MT DTT DM493GU MA Agonist DM493GU RN Metabolism and biologic effects of 5-oxoeicosanoids on human neutrophils. J Immunol. 1996 Jan 1;156(1):336-42. DM493GU RU https://pubmed.ncbi.nlm.nih.gov/8598482 DM6FSUW DI DM6FSUW DM6FSUW DN 5-oxo-C20:3 DM6FSUW MI TT7WBSV DM6FSUW MN Oxoeicosanoid receptor 1 (OXER1) DM6FSUW MT DTT DM6FSUW MA Agonist DM6FSUW RN Structural requirements for activation of the 5-oxo-6E,8Z, 11Z,14Z-eicosatetraenoic acid (5-oxo-ETE) receptor: identification of a mead acid metabolite with potent agonist activity. J Pharmacol Exp Ther. 2008 May;325(2):698-707. DM6FSUW RU https://pubmed.ncbi.nlm.nih.gov/18292294 DM56TVA DI DM56TVA DM56TVA DN 5-oxo-ODE DM56TVA MI TT7WBSV DM56TVA MN Oxoeicosanoid receptor 1 (OXER1) DM56TVA MT DTT DM56TVA MA Agonist DM56TVA RN Human neutrophils convert the sebum-derived polyunsaturated fatty acid Sebaleic acid to a potent granulocyte chemoattractant. J Biol Chem. 2008 Apr 25;283(17):11234-43. DM56TVA RU https://pubmed.ncbi.nlm.nih.gov/18287092 DMPLB3S DI DMPLB3S DMPLB3S DN 5PAM523 DMPLB3S MI TTHS256 DMPLB3S MN Metabotropic glutamate receptor 5 (mGluR5) DMPLB3S MT DTT DMPLB3S MA Modulator (allosteric modulator) DMPLB3S RN Mechanism based neurotoxicity of mGlu5 positive allosteric modulators--development challenges for a promising novel antipsychotic target. Neuropharmacology. 2014 Jul;82:161-73. DMPLB3S RU https://pubmed.ncbi.nlm.nih.gov/23291536 DMKHFV4 DI DMKHFV4 DMKHFV4 DN 5-PENTYL-2-PHENOXYPHENOL DMKHFV4 MI TTVTX4N DMKHFV4 MN Bacterial Fatty acid synthetase I (Bact inhA) DMKHFV4 MT DTT DMKHFV4 MA Inhibitor DMKHFV4 RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DMKHFV4 RU https://pubmed.ncbi.nlm.nih.gov/10592235 DMZKJF8 DI DMZKJF8 DMZKJF8 DN 5-Phenethyl-1H-pyrazole-3-carboxylic acid DMZKJF8 MI TTWNV8U DMZKJF8 MN Nicotinic acid receptor (HCAR2) DMZKJF8 MT DTT DMZKJF8 MA Inhibitor DMZKJF8 RN Pyrazole derivatives as partial agonists for the nicotinic acid receptor. J Med Chem. 2003 Aug 28;46(18):3945-51. DMZKJF8 RU https://pubmed.ncbi.nlm.nih.gov/12930155 DMWI7XJ DI DMWI7XJ DMWI7XJ DN 5-Phenethyl-quinazoline-2,4-diamine DMWI7XJ MI TT9SL3Q DMWI7XJ MN Polypeptide deformylase (PDF) DMWI7XJ MT DTT DMWI7XJ MA Inhibitor DMWI7XJ RN 2,4-Diamino-5-substituted-quinazolines as inhibitors of a human dihydrofolate reductase with a site-directed mutation at position 22 and of the dih... J Med Chem. 1995 Mar 3;38(5):745-52. DMWI7XJ RU https://pubmed.ncbi.nlm.nih.gov/7877140 DMZ6TRV DI DMZ6TRV DMZ6TRV DN 5-phenyl-1,3,4-oxadiazole-2(3H)-thione DMZ6TRV MI TTULVH8 DMZ6TRV MN Tyrosinase (TYR) DMZ6TRV MT DTT DMZ6TRV MA Inhibitor DMZ6TRV RN New potent inhibitors of tyrosinase: novel clues to binding of 1,3,4-thiadiazole-2(3H)-thiones, 1,3,4-oxadiazole-2(3H)-thiones, 4-amino-1,2,4-triaz... Bioorg Med Chem. 2010 Jun 1;18(11):4042-8. DMZ6TRV RU https://pubmed.ncbi.nlm.nih.gov/20452224 DMCKBQY DI DMCKBQY DMCKBQY DN 5-phenyl-1,3,4-thiadiazole-2(3H)-thione DMCKBQY MI TTULVH8 DMCKBQY MN Tyrosinase (TYR) DMCKBQY MT DTT DMCKBQY MA Inhibitor DMCKBQY RN New potent inhibitors of tyrosinase: novel clues to binding of 1,3,4-thiadiazole-2(3H)-thiones, 1,3,4-oxadiazole-2(3H)-thiones, 4-amino-1,2,4-triaz... Bioorg Med Chem. 2010 Jun 1;18(11):4042-8. DMCKBQY RU https://pubmed.ncbi.nlm.nih.gov/20452224 DMWF4HX DI DMWF4HX DMWF4HX DN 5-phenyl-1H-1,2,3-triazole DMWF4HX MI TTZJYKH DMWF4HX MN Indoleamine 2,3-dioxygenase 1 (IDO1) DMWF4HX MT DTT DMWF4HX MA Inhibitor DMWF4HX RN Rational design of indoleamine 2,3-dioxygenase inhibitors. J Med Chem. 2010 Feb 11;53(3):1172-89. DMWF4HX RU https://pubmed.ncbi.nlm.nih.gov/20055453 DMJBEIF DI DMJBEIF DMJBEIF DN 5-phenyl-1H-indazol-3-amine DMJBEIF MI TTRMX3V DMJBEIF MN Janus kinase 2 (JAK-2) DMJBEIF MT DTT DMJBEIF MA Inhibitor DMJBEIF RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DMJBEIF RU https://pubmed.ncbi.nlm.nih.gov/10592235 DMQHU0J DI DMQHU0J DMQHU0J DN 5-phenyl-2-(4-(piperidin-1-yl)butyl)oxazole DMQHU0J MI TT9JNIC DMQHU0J MN Histamine H3 receptor (H3R) DMQHU0J MT DTT DMQHU0J MA Inhibitor DMQHU0J RN Azole derivatives as histamine H3 receptor antagonists, part 2: C-C and C-S coupled heterocycles. Bioorg Med Chem Lett. 2010 Oct 1;20(19):5883-6. DMQHU0J RU https://pubmed.ncbi.nlm.nih.gov/20727744 DMLK2VT DI DMLK2VT DMLK2VT DN 5-Phenyl-6-thia-10b-aza-benzo[e]azulen-4-one DMLK2VT MI TTPTXIN DMLK2VT MN Translocator protein (TSPO) DMLK2VT MT DTT DMLK2VT MA Inhibitor DMLK2VT RN Novel ligands specific for mitochondrial benzodiazepine receptors: 6-arylpyrrolo[2,1-d][1,5]benzothiazepine derivatives. Synthesis, structure-activ... J Med Chem. 1994 May 13;37(10):1427-38. DMLK2VT RU https://pubmed.ncbi.nlm.nih.gov/8182701 DMUBCVL DI DMUBCVL DMUBCVL DN 5-Phenyl-6-thia-10b-aza-benzo[e]azulene DMUBCVL MI TTPTXIN DMUBCVL MN Translocator protein (TSPO) DMUBCVL MT DTT DMUBCVL MA Inhibitor DMUBCVL RN A concerted study using binding measurements, X-ray structural data, and molecular modeling on the stereochemical features responsible for the affi... J Med Chem. 1995 Nov 10;38(23):4730-8. DMUBCVL RU https://pubmed.ncbi.nlm.nih.gov/7473601 DMX6R0H DI DMX6R0H DMX6R0H DN 5-phenylamino-4-cyano-3-hydroxy-isothiazole DMX6R0H MI TTIDAPM DMX6R0H MN ERK activator kinase 1 (MEK1) DMX6R0H MT DTT DMX6R0H MA Inhibitor DMX6R0H RN Discovery of 3-hydroxy-4-carboxyalkylamidino-5-arylamino-isothiazoles as potent MEK1 inhibitors. Bioorg Med Chem Lett. 2006 Aug 1;16(15):3975-80. DMX6R0H RU https://pubmed.ncbi.nlm.nih.gov/16725322 DM3B6A8 DI DM3B6A8 DM3B6A8 DN 5-Phenyl-pentanoic acid benzyl-hydroxy-amide DM3B6A8 MI TT8NGED DM3B6A8 MN Prostaglandin G/H synthase 1 (COX-1) DM3B6A8 MT DTT DM3B6A8 MA Inhibitor DM3B6A8 RN Differential effects of a series of hydroxamic acid derivatives on 5-lipoxygenase and cyclooxygenase from neutrophils and 12-lipoxygenase from plat... J Med Chem. 1989 Aug;32(8):1836-42. DM3B6A8 RU https://pubmed.ncbi.nlm.nih.gov/2502629 DM3B6A8 DI DM3B6A8 DM3B6A8 DN 5-Phenyl-pentanoic acid benzyl-hydroxy-amide DM3B6A8 MI TTVKILB DM3B6A8 MN Prostaglandin G/H synthase 2 (COX-2) DM3B6A8 MT DTT DM3B6A8 MA Inhibitor DM3B6A8 RN Differential effects of a series of hydroxamic acid derivatives on 5-lipoxygenase and cyclooxygenase from neutrophils and 12-lipoxygenase from plat... J Med Chem. 1989 Aug;32(8):1836-42. DM3B6A8 RU https://pubmed.ncbi.nlm.nih.gov/2502629 DMMWYFR DI DMMWYFR DMMWYFR DN 5-Phenylsulfanyl-2,4-Quinazolinediamine DMMWYFR MI TT9SL3Q DMMWYFR MN Polypeptide deformylase (PDF) DMMWYFR MT DTT DMMWYFR MA Inhibitor DMMWYFR RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMMWYFR RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMQMZ0Y DI DMQMZ0Y DMQMZ0Y DN 5'-phenylthio-ImmH DMQMZ0Y MI TTMCF1Y DMQMZ0Y MN Purine nucleoside phosphorylase (PNP) DMQMZ0Y MT DTT DMQMZ0Y MA Inhibitor DMQMZ0Y RN Immucillins in custom catalytic-site cavities. Bioorg Med Chem Lett. 2008 Nov 15;18(22):5900-3. DMQMZ0Y RU https://pubmed.ncbi.nlm.nih.gov/18778937 DMGK05W DI DMGK05W DMGK05W DN 5-Phosphoribosyl-1-(Beta-Methylene) Pyrophosphate DMGK05W MI TTH29K0 DMGK05W MN Mycobacterium Nicotinate-nucleotide pyrophosphorylase (MycB nadC) DMGK05W MT DTT DMGK05W MA Inhibitor DMGK05W RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMGK05W RU https://pubmed.ncbi.nlm.nih.gov/17139284 DM6A902 DI DM6A902 DM6A902 DN 5-propenyl-2'-deoxyuridine triphosphate DM6A902 MI TTIU7X1 DM6A902 MN Herpes simplex virus DNA polymerase UL30 (HSV UL30) DM6A902 MT DTT DM6A902 MA Inhibitor DM6A902 RN Inhibition of human hepatitis B virus DNA polymerase and duck hepatitis B virus DNA polymerase by triphosphates of thymidine analogs and pharmacokinetic properties of the corresponding nucleosides. JMed Virol. 1988 Dec;26(4):353-62. DM6A902 RU https://pubmed.ncbi.nlm.nih.gov/3145322 DM762FY DI DM762FY DM762FY DN 5-propenyl-arabinofuranosyluracil 5'-triphosphate DM762FY MI TTIU7X1 DM762FY MN Herpes simplex virus DNA polymerase UL30 (HSV UL30) DM762FY MT DTT DM762FY MA Inhibitor DM762FY RN Inhibition of human hepatitis B virus DNA polymerase and duck hepatitis B virus DNA polymerase by triphosphates of thymidine analogs and pharmacokinetic properties of the corresponding nucleosides. JMed Virol. 1988 Dec;26(4):353-62. DM762FY RU https://pubmed.ncbi.nlm.nih.gov/3145322 DMSPVXM DI DMSPVXM DMSPVXM DN 5-Propyl-1H-pyrazole-3-carboxylic acid DMSPVXM MI TTWNV8U DMSPVXM MN Nicotinic acid receptor (HCAR2) DMSPVXM MT DTT DMSPVXM MA Inhibitor DMSPVXM RN Pyrazole derivatives as partial agonists for the nicotinic acid receptor. J Med Chem. 2003 Aug 28;46(18):3945-51. DMSPVXM RU https://pubmed.ncbi.nlm.nih.gov/12930155 DM9IHV6 DI DM9IHV6 DM9IHV6 DN 5-propyl-2'-deoxyuridine DM9IHV6 MI TTP3QRF DM9IHV6 MN Thymidine kinase 1 (TK1) DM9IHV6 MT DTT DM9IHV6 MA Inhibitor DM9IHV6 RN Sensitivity of monkey B virus (Cercopithecine herpesvirus 1) to antiviral drugs: role of thymidine kinase in antiviral activities of substrate anal... Antimicrob Agents Chemother. 2007 Jun;51(6):2028-34. DM9IHV6 RU https://pubmed.ncbi.nlm.nih.gov/17438061 DM2W0AD DI DM2W0AD DM2W0AD DN 5-p-Tolyl-1H-[1,2,3]triazole DM2W0AD MI TTZL0OI DM2W0AD MN Methionine aminopeptidase 2 (METAP2) DM2W0AD MT DTT DM2W0AD MA Inhibitor DM2W0AD RN 4-Aryl-1,2,3-triazole: a novel template for a reversible methionine aminopeptidase 2 inhibitor, optimized to inhibit angiogenesis in vivo. J Med Chem. 2005 Sep 8;48(18):5644-7. DM2W0AD RU https://pubmed.ncbi.nlm.nih.gov/16134930 DMV4ICS DI DMV4ICS DMV4ICS DN 5-p-Tolylsulfanyl-quinazoline-2,4-diamine DMV4ICS MI TT9SL3Q DMV4ICS MN Polypeptide deformylase (PDF) DMV4ICS MT DTT DMV4ICS MA Inhibitor DMV4ICS RN X-Ray crystal structures of Candida albicans dihydrofolate reductase: high resolution ternary complexes in which the dihydronicotinamide moiety of ... J Med Chem. 2001 Aug 30;44(18):2928-32. DMV4ICS RU https://pubmed.ncbi.nlm.nih.gov/11520201 DMLRM9Z DI DMLRM9Z DMLRM9Z DN 5-Pyridin-3-yl-1,3-dihydro-2H-indol-2-one DMLRM9Z MI TTSZLWK DMLRM9Z MN Aromatase (CYP19A1) DMLRM9Z MT DTT DMLRM9Z MA Inhibitor DMLRM9Z RN In vivo active aldosterone synthase inhibitors with improved selectivity: lead optimization providing a series of pyridine substituted 3,4-dihydro-... J Med Chem. 2008 Dec 25;51(24):8077-87. DMLRM9Z RU https://pubmed.ncbi.nlm.nih.gov/19049427 DMLRM9Z DI DMLRM9Z DMLRM9Z DN 5-Pyridin-3-yl-1,3-dihydro-2H-indol-2-one DMLRM9Z MI TTIQUX7 DMLRM9Z MN Steroid 11-beta-hydroxylase (CYP11B1) DMLRM9Z MT DTT DMLRM9Z MA Inhibitor DMLRM9Z RN In vivo active aldosterone synthase inhibitors with improved selectivity: lead optimization providing a series of pyridine substituted 3,4-dihydro-... J Med Chem. 2008 Dec 25;51(24):8077-87. DMLRM9Z RU https://pubmed.ncbi.nlm.nih.gov/19049427 DMQYIBC DI DMQYIBC DMQYIBC DN 5-Pyridin-3-yl-2,3-dihydro-1H-inden-1-one DMQYIBC MI TTSZLWK DMQYIBC MN Aromatase (CYP19A1) DMQYIBC MT DTT DMQYIBC MA Inhibitor DMQYIBC RN In vivo active aldosterone synthase inhibitors with improved selectivity: lead optimization providing a series of pyridine substituted 3,4-dihydro-... J Med Chem. 2008 Dec 25;51(24):8077-87. DMQYIBC RU https://pubmed.ncbi.nlm.nih.gov/19049427 DMQYIBC DI DMQYIBC DMQYIBC DN 5-Pyridin-3-yl-2,3-dihydro-1H-inden-1-one DMQYIBC MI TTIQUX7 DMQYIBC MN Steroid 11-beta-hydroxylase (CYP11B1) DMQYIBC MT DTT DMQYIBC MA Inhibitor DMQYIBC RN In vivo active aldosterone synthase inhibitors with improved selectivity: lead optimization providing a series of pyridine substituted 3,4-dihydro-... J Med Chem. 2008 Dec 25;51(24):8077-87. DMQYIBC RU https://pubmed.ncbi.nlm.nih.gov/19049427 DMZQPTU DI DMZQPTU DMZQPTU DN 5-Pyridin-3-yl-thiophene-2-carbaldehyde oxime DMZQPTU MI TTXV4FI DMZQPTU MN Albendazole monooxygenase (CYP3A4) DMZQPTU MT DTT DMZQPTU MA Inhibitor DMZQPTU RN 5-substituted, 6-substituted, and unsubstituted 3-heteroaromatic pyridine analogues of nicotine as selective inhibitors of cytochrome P-450 2A6. J Med Chem. 2005 Jan 13;48(1):224-39. DMZQPTU RU https://pubmed.ncbi.nlm.nih.gov/15634016 DMNYQGS DI DMNYQGS DMNYQGS DN 5''-Quinolin-4-yl-[2,4'']bithiazolyl-2''-ylamine DMNYQGS MI TTP4520 DMNYQGS MN TGF-beta receptor type I (TGFBR1) DMNYQGS MT DTT DMNYQGS MA Inhibitor DMNYQGS RN Identification of 1,5-naphthyridine derivatives as a novel series of potent and selective TGF-beta type I receptor inhibitors. J Med Chem. 2004 Aug 26;47(18):4494-506. DMNYQGS RU https://pubmed.ncbi.nlm.nih.gov/15317461 DMVX063 DI DMVX063 DMVX063 DN 5-QUINOXALIN-6-YLMETHYLENE-THIAZOLIDINE-2,4-DIONE DMVX063 MI TTGP7BY DMVX063 MN Monoamine oxidase type B (MAO-B) DMVX063 MT DTT DMVX063 MA Inhibitor DMVX063 RN Identification of novel monoamine oxidase B inhibitors by structure-based virtual screening. Bioorg Med Chem Lett. 2010 Sep 1;20(17):5295-8. DMVX063 RU https://pubmed.ncbi.nlm.nih.gov/20650633 DMVX063 DI DMVX063 DMVX063 DN 5-QUINOXALIN-6-YLMETHYLENE-THIAZOLIDINE-2,4-DIONE DMVX063 MI TTHBTOP DMVX063 MN PI3-kinase gamma (PIK3CG) DMVX063 MT DTT DMVX063 MA Inhibitor DMVX063 RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DMVX063 RU https://pubmed.ncbi.nlm.nih.gov/10592235 DM0PQH1 DI DM0PQH1 DM0PQH1 DN 5'-S-ethyl-5'-thioadenosine DM0PQH1 MI TTE2KUJ DM0PQH1 MN Adenosylhomocysteinase (AHCY) DM0PQH1 MT DTT DM0PQH1 MA Inhibitor DM0PQH1 RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DM0PQH1 RU https://pubmed.ncbi.nlm.nih.gov/10592235 DM3Z6G4 DI DM3Z6G4 DM3Z6G4 DN 5S-HETE DM3Z6G4 MI TT2J34L DM3Z6G4 MN Arachidonate 5-lipoxygenase (5-LOX) DM3Z6G4 MT DTT DM3Z6G4 MA Inhibitor DM3Z6G4 RN Preview of potential therapeutic applications of leukotriene B4 inhibitors in dermatology. Skin Pharmacol Appl Skin Physiol. 2000 Sep-Oct;13(5):235-45. DM3Z6G4 RU https://pubmed.ncbi.nlm.nih.gov/10940813 DM3Z6G4 DI DM3Z6G4 DM3Z6G4 DN 5S-HETE DM3Z6G4 MI TT7WBSV DM3Z6G4 MN Oxoeicosanoid receptor 1 (OXER1) DM3Z6G4 MT DTT DM3Z6G4 MA Agonist DM3Z6G4 RN TG1019/OXE, a Galpha(i/o)-protein-coupled receptor, mediates 5-oxo-eicosatetraenoic acid-induced chemotaxis. Biochem Biophys Res Commun. 2005 Sep 9;334(4):987-95. DM3Z6G4 RU https://pubmed.ncbi.nlm.nih.gov/16039985 DM3Z6G4 DI DM3Z6G4 DM3Z6G4 DN 5S-HETE DM3Z6G4 MI TTMI6F5 DM3Z6G4 MN Transient receptor potential cation channel V1 (TRPV1) DM3Z6G4 MT DTT DM3Z6G4 MA Activator DM3Z6G4 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 507). DM3Z6G4 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=507 DME1304 DI DME1304 DME1304 DN 5S-HPETE DME1304 MI TT7WBSV DME1304 MN Oxoeicosanoid receptor 1 (OXER1) DME1304 MT DTT DME1304 MA Agonist DME1304 RN TG1019/OXE, a Galpha(i/o)-protein-coupled receptor, mediates 5-oxo-eicosatetraenoic acid-induced chemotaxis. Biochem Biophys Res Commun. 2005 Sep 9;334(4):987-95. DME1304 RU https://pubmed.ncbi.nlm.nih.gov/16039985 DME1304 DI DME1304 DME1304 DN 5S-HPETE DME1304 MI TTMI6F5 DME1304 MN Transient receptor potential cation channel V1 (TRPV1) DME1304 MT DTT DME1304 MA Activator DME1304 RN Direct activation of capsaicin receptors by products of lipoxygenases: endogenous capsaicin-like substances. Proc Natl Acad Sci U S A. 2000 May 23;97(11):6155-60. DME1304 RU https://pubmed.ncbi.nlm.nih.gov/10823958 DMCG6EK DI DMCG6EK DMCG6EK DN 5-tert-Butyl-2-(4-ethynyl-phenyl)-[1,3]dithiane DMCG6EK MI TTNJYV2 DMCG6EK MN Gamma-aminobutyric acid receptor (GAR) DMCG6EK MT DTT DMCG6EK MA Inhibitor DMCG6EK RN Synthesis of carbon-11-, fluorine-18-, and iodine-125-labeled GABAA-gated chloride ion channel blockers: substituted 5-tert-butyl-2-phenyl-1,3-dith... J Med Chem. 1995 Jul 7;38(14):2663-71. DMCG6EK RU https://pubmed.ncbi.nlm.nih.gov/7629805 DMQK32F DI DMQK32F DMQK32F DN 5-tert-Butyl-2-(4-fluoro-phenyl)-[1,3]dithiane DMQK32F MI TTNJYV2 DMQK32F MN Gamma-aminobutyric acid receptor (GAR) DMQK32F MT DTT DMQK32F MA Inhibitor DMQK32F RN Synthesis of carbon-11-, fluorine-18-, and iodine-125-labeled GABAA-gated chloride ion channel blockers: substituted 5-tert-butyl-2-phenyl-1,3-dith... J Med Chem. 1995 Jul 7;38(14):2663-71. DMQK32F RU https://pubmed.ncbi.nlm.nih.gov/7629805 DMF4RGW DI DMF4RGW DMF4RGW DN 5-thia-8,11,14,17-eicosatetraenoic acid DMF4RGW MI TTVKILB DMF4RGW MN Prostaglandin G/H synthase 2 (COX-2) DMF4RGW MT DTT DMF4RGW MA Inhibitor DMF4RGW RN Cox-2 inhibitory effects of naturally occurring and modified fatty acids. J Nat Prod. 2001 Jun;64(6):745-9. DMF4RGW RU https://pubmed.ncbi.nlm.nih.gov/11421736 DMTB91D DI DMTB91D DMTB91D DN 5-tosyl-5H-dibenzo[b,d]azepin-7(6H)-one DMTB91D MI TTMNI76 DMTB91D MN Calcium-activated potassium channel (KCN) DMTB91D MT DTT DMTB91D MA Inhibitor DMTB91D RN Inhibitors of potassium channels KV1.3 and IK-1 as immunosuppressants. Bioorg Med Chem Lett. 2009 Apr 15;19(8):2299-304. DMTB91D RU https://pubmed.ncbi.nlm.nih.gov/19282171 DMOR04W DI DMOR04W DMOR04W DN 6-((1H-imidazol-1-yl)methyl)-2H-chromene-2-thione DMOR04W MI TTSZLWK DMOR04W MN Aromatase (CYP19A1) DMOR04W MT DTT DMOR04W MA Inhibitor DMOR04W RN Fast three dimensional pharmacophore virtual screening of new potent non-steroid aromatase inhibitors. J Med Chem. 2009 Jan 8;52(1):143-50. DMOR04W RU https://pubmed.ncbi.nlm.nih.gov/19072235 DM5RX0K DI DM5RX0K DM5RX0K DN 6-(1H-Benzoimidazol-2-yl)-benzocyclohepten-7-one DM5RX0K MI TTUTJGQ DM5RX0K MN Vascular endothelial growth factor receptor 2 (KDR) DM5RX0K MT DTT DM5RX0K MA Inhibitor DM5RX0K RN Optimization of the indolyl quinolinone class of KDR (VEGFR-2) kinase inhibitors: effects of 5-amido- and 5-sulphonamido-indolyl groups on pharmaco... Bioorg Med Chem Lett. 2004 Jan 19;14(2):351-5. DM5RX0K RU https://pubmed.ncbi.nlm.nih.gov/14698157 DM1TOFD DI DM1TOFD DM1TOFD DN 6-(1H-Indole-2-sulfonyl)-2H-pyridazin-3-one DM1TOFD MI TTFBNVI DM1TOFD MN Aldose reductase (AKR1B1) DM1TOFD MT DTT DM1TOFD MA Inhibitor DM1TOFD RN A novel series of non-carboxylic acid, non-hydantoin inhibitors of aldose reductase with potent oral activity in diabetic rat models: 6-(5-chloro-3... J Med Chem. 2005 Oct 6;48(20):6326-39. DM1TOFD RU https://pubmed.ncbi.nlm.nih.gov/16190759 DMRU963 DI DMRU963 DMRU963 DN 6-(2,5-Difluoro-4-hydroxy-phenyl)-naphthalen-2-ol DMRU963 MI TTZAYWL DMRU963 MN Estrogen receptor (ESR) DMRU963 MT DTT DMRU963 MA Inhibitor DMRU963 RN ERbeta ligands. 3. Exploiting two binding orientations of the 2-phenylnaphthalene scaffold to achieve ERbeta selectivity. J Med Chem. 2005 Jun 16;48(12):3953-79. DMRU963 RU https://pubmed.ncbi.nlm.nih.gov/15943471 DMRU963 DI DMRU963 DMRU963 DN 6-(2,5-Difluoro-4-hydroxy-phenyl)-naphthalen-2-ol DMRU963 MI TTOM3J0 DMRU963 MN Estrogen receptor beta (ESR2) DMRU963 MT DTT DMRU963 MA Inhibitor DMRU963 RN ERbeta ligands. 3. Exploiting two binding orientations of the 2-phenylnaphthalene scaffold to achieve ERbeta selectivity. J Med Chem. 2005 Jun 16;48(12):3953-79. DMRU963 RU https://pubmed.ncbi.nlm.nih.gov/15943471 DMFALTY DI DMFALTY DMFALTY DN 6-(2,6-Difluoro-4-hydroxy-phenyl)-naphthalen-2-ol DMFALTY MI TTZAYWL DMFALTY MN Estrogen receptor (ESR) DMFALTY MT DTT DMFALTY MA Inhibitor DMFALTY RN ERbeta ligands. 3. Exploiting two binding orientations of the 2-phenylnaphthalene scaffold to achieve ERbeta selectivity. J Med Chem. 2005 Jun 16;48(12):3953-79. DMFALTY RU https://pubmed.ncbi.nlm.nih.gov/15943471 DMFALTY DI DMFALTY DMFALTY DN 6-(2,6-Difluoro-4-hydroxy-phenyl)-naphthalen-2-ol DMFALTY MI TTOM3J0 DMFALTY MN Estrogen receptor beta (ESR2) DMFALTY MT DTT DMFALTY MA Inhibitor DMFALTY RN ERbeta ligands. 3. Exploiting two binding orientations of the 2-phenylnaphthalene scaffold to achieve ERbeta selectivity. J Med Chem. 2005 Jun 16;48(12):3953-79. DMFALTY RU https://pubmed.ncbi.nlm.nih.gov/15943471 DMA9LFR DI DMA9LFR DMA9LFR DN 6-(2-acetylphenyl)-2-morpholin-4-ylchromen-4-one DMA9LFR MI TTK3PY9 DMA9LFR MN DNA-dependent protein kinase catalytic (PRKDC) DMA9LFR MT DTT DMA9LFR MA Inhibitor DMA9LFR RN Discovery of potent chromen-4-one inhibitors of the DNA-dependent protein kinase (DNA-PK) using a small-molecule library approach. J Med Chem. 2005 Dec 1;48(24):7829-46. DMA9LFR RU https://pubmed.ncbi.nlm.nih.gov/16302822 DMO724D DI DMO724D DMO724D DN 6-(2-Amino-ethyl)-biphenyl-2,3,4'-triol DMO724D MI TTZFYLI DMO724D MN Dopamine D1 receptor (D1R) DMO724D MT DTT DMO724D MA Inhibitor DMO724D RN Synthesis and dopaminergic binding of 2-aryldopamine analogues: phenethylamines, 3-benzazepines, and 9-(aminomethyl)fluorenes. J Med Chem. 1986 Oct;29(10):1904-12. DMO724D RU https://pubmed.ncbi.nlm.nih.gov/3761310 DMI8KOF DI DMI8KOF DMI8KOF DN 6-(2-Amino-ethyl)-biphenyl-2,3-diol DMI8KOF MI TTZFYLI DMI8KOF MN Dopamine D1 receptor (D1R) DMI8KOF MT DTT DMI8KOF MA Inhibitor DMI8KOF RN Synthesis and dopaminergic binding of 2-aryldopamine analogues: phenethylamines, 3-benzazepines, and 9-(aminomethyl)fluorenes. J Med Chem. 1986 Oct;29(10):1904-12. DMI8KOF RU https://pubmed.ncbi.nlm.nih.gov/3761310 DMXFRW9 DI DMXFRW9 DMXFRW9 DN 6-(2-aminophenoxy)benzo[d]isothiazol-3-amine DMXFRW9 MI TTISGCA DMXFRW9 MN Toll-like receptor 4 (TLR4) DMXFRW9 MT DTT DMXFRW9 MA Inhibitor DMXFRW9 RN Small molecule modulators of toll-like receptors. J Med Chem. 2008 Nov 13;51(21):6621-6. DMXFRW9 RU https://pubmed.ncbi.nlm.nih.gov/18828583 DMUD2R9 DI DMUD2R9 DMUD2R9 DN 6-(2-benzylisoindolin-5-yloxy)nicotinamide DMUD2R9 MI TTKWM86 DMUD2R9 MN Opioid receptor mu (MOP) DMUD2R9 MT DTT DMUD2R9 MA Inhibitor DMUD2R9 RN Structure activity relationship studies of carboxamido-biaryl ethers as opioid receptor antagonists (OpRAs). Part 2. Bioorg Med Chem Lett. 2007 Dec 15;17(24):6841-6. DMUD2R9 RU https://pubmed.ncbi.nlm.nih.gov/17980586 DM9LKXD DI DM9LKXD DM9LKXD DN 6-(2-Bromo-acetylamino)-hexanoic acid phenylamide DM9LKXD MI TTBH0VX DM9LKXD MN Histone deacetylase (HDAC) DM9LKXD MT DTT DM9LKXD MA Inhibitor DM9LKXD RN Novel inhibitors of human histone deacetylases: design, synthesis, enzyme inhibition, and cancer cell growth inhibition of SAHA-based non-hydroxama... J Med Chem. 2005 Feb 24;48(4):1019-32. DM9LKXD RU https://pubmed.ncbi.nlm.nih.gov/15715470 DM9LKXD DI DM9LKXD DM9LKXD DN 6-(2-Bromo-acetylamino)-hexanoic acid phenylamide DM9LKXD MI TT6R7JZ DM9LKXD MN Histone deacetylase 1 (HDAC1) DM9LKXD MT DTT DM9LKXD MA Inhibitor DM9LKXD RN Novel inhibitors of human histone deacetylases: design, synthesis, enzyme inhibition, and cancer cell growth inhibition of SAHA-based non-hydroxama... J Med Chem. 2005 Feb 24;48(4):1019-32. DM9LKXD RU https://pubmed.ncbi.nlm.nih.gov/15715470 DM9LKXD DI DM9LKXD DM9LKXD DN 6-(2-Bromo-acetylamino)-hexanoic acid phenylamide DM9LKXD MI TTYHPU6 DM9LKXD MN Histone deacetylase 10 (HDAC10) DM9LKXD MT DTT DM9LKXD MA Inhibitor DM9LKXD RN Novel inhibitors of human histone deacetylases: design, synthesis, enzyme inhibition, and cancer cell growth inhibition of SAHA-based non-hydroxama... J Med Chem. 2005 Feb 24;48(4):1019-32. DM9LKXD RU https://pubmed.ncbi.nlm.nih.gov/15715470 DM9LKXD DI DM9LKXD DM9LKXD DN 6-(2-Bromo-acetylamino)-hexanoic acid phenylamide DM9LKXD MI TTSHTOI DM9LKXD MN Histone deacetylase 2 (HDAC2) DM9LKXD MT DTT DM9LKXD MA Inhibitor DM9LKXD RN Novel inhibitors of human histone deacetylases: design, synthesis, enzyme inhibition, and cancer cell growth inhibition of SAHA-based non-hydroxama... J Med Chem. 2005 Feb 24;48(4):1019-32. DM9LKXD RU https://pubmed.ncbi.nlm.nih.gov/15715470 DM9LKXD DI DM9LKXD DM9LKXD DN 6-(2-Bromo-acetylamino)-hexanoic acid phenylamide DM9LKXD MI TTTQGH8 DM9LKXD MN Histone deacetylase 4 (HDAC4) DM9LKXD MT DTT DM9LKXD MA Inhibitor DM9LKXD RN Novel inhibitors of human histone deacetylases: design, synthesis, enzyme inhibition, and cancer cell growth inhibition of SAHA-based non-hydroxama... J Med Chem. 2005 Feb 24;48(4):1019-32. DM9LKXD RU https://pubmed.ncbi.nlm.nih.gov/15715470 DM9LKXD DI DM9LKXD DM9LKXD DN 6-(2-Bromo-acetylamino)-hexanoic acid phenylamide DM9LKXD MI TT5ZKDI DM9LKXD MN Histone deacetylase 6 (HDAC6) DM9LKXD MT DTT DM9LKXD MA Inhibitor DM9LKXD RN Novel inhibitors of human histone deacetylases: design, synthesis, enzyme inhibition, and cancer cell growth inhibition of SAHA-based non-hydroxama... J Med Chem. 2005 Feb 24;48(4):1019-32. DM9LKXD RU https://pubmed.ncbi.nlm.nih.gov/15715470 DM9LKXD DI DM9LKXD DM9LKXD DN 6-(2-Bromo-acetylamino)-hexanoic acid phenylamide DM9LKXD MI TTT6LFV DM9LKXD MN Histone deacetylase 8 (HDAC8) DM9LKXD MT DTT DM9LKXD MA Inhibitor DM9LKXD RN Novel inhibitors of human histone deacetylases: design, synthesis, enzyme inhibition, and cancer cell growth inhibition of SAHA-based non-hydroxama... J Med Chem. 2005 Feb 24;48(4):1019-32. DM9LKXD RU https://pubmed.ncbi.nlm.nih.gov/15715470 DMYDHLN DI DMYDHLN DMYDHLN DN 6-(2-Bromo-benzenesulfonyl)-2H-pyridazin-3-one DMYDHLN MI TTFBNVI DMYDHLN MN Aldose reductase (AKR1B1) DMYDHLN MT DTT DMYDHLN MA Inhibitor DMYDHLN RN A novel series of non-carboxylic acid, non-hydantoin inhibitors of aldose reductase with potent oral activity in diabetic rat models: 6-(5-chloro-3... J Med Chem. 2005 Oct 6;48(20):6326-39. DMYDHLN RU https://pubmed.ncbi.nlm.nih.gov/16190759 DMTPAMS DI DMTPAMS DMTPAMS DN 6-(2-Chloro-4-hydroxy-phenyl)-naphthalen-2-ol DMTPAMS MI TTZAYWL DMTPAMS MN Estrogen receptor (ESR) DMTPAMS MT DTT DMTPAMS MA Inhibitor DMTPAMS RN ERbeta ligands. 3. Exploiting two binding orientations of the 2-phenylnaphthalene scaffold to achieve ERbeta selectivity. J Med Chem. 2005 Jun 16;48(12):3953-79. DMTPAMS RU https://pubmed.ncbi.nlm.nih.gov/15943471 DMTPAMS DI DMTPAMS DMTPAMS DN 6-(2-Chloro-4-hydroxy-phenyl)-naphthalen-2-ol DMTPAMS MI TTOM3J0 DMTPAMS MN Estrogen receptor beta (ESR2) DMTPAMS MT DTT DMTPAMS MA Inhibitor DMTPAMS RN ERbeta ligands. 3. Exploiting two binding orientations of the 2-phenylnaphthalene scaffold to achieve ERbeta selectivity. J Med Chem. 2005 Jun 16;48(12):3953-79. DMTPAMS RU https://pubmed.ncbi.nlm.nih.gov/15943471 DM2Y9O4 DI DM2Y9O4 DM2Y9O4 DN 6-(2-Chloro-benzenesulfonyl)-2H-pyridazin-3-one DM2Y9O4 MI TTFBNVI DM2Y9O4 MN Aldose reductase (AKR1B1) DM2Y9O4 MT DTT DM2Y9O4 MA Inhibitor DM2Y9O4 RN A novel series of non-carboxylic acid, non-hydantoin inhibitors of aldose reductase with potent oral activity in diabetic rat models: 6-(5-chloro-3... J Med Chem. 2005 Oct 6;48(20):6326-39. DM2Y9O4 RU https://pubmed.ncbi.nlm.nih.gov/16190759 DM3VME7 DI DM3VME7 DM3VME7 DN 6-(2-Dipropylamino-ethyl)-biphenyl-2,3,4'-triol DM3VME7 MI TTZFYLI DM3VME7 MN Dopamine D1 receptor (D1R) DM3VME7 MT DTT DM3VME7 MA Inhibitor DM3VME7 RN Synthesis and dopaminergic binding of 2-aryldopamine analogues: phenethylamines, 3-benzazepines, and 9-(aminomethyl)fluorenes. J Med Chem. 1986 Oct;29(10):1904-12. DM3VME7 RU https://pubmed.ncbi.nlm.nih.gov/3761310 DMNQWZO DI DMNQWZO DMNQWZO DN 6-(2-Dipropylamino-ethyl)-biphenyl-2,3-diol DMNQWZO MI TTZFYLI DMNQWZO MN Dopamine D1 receptor (D1R) DMNQWZO MT DTT DMNQWZO MA Inhibitor DMNQWZO RN Synthesis and dopaminergic binding of 2-aryldopamine analogues: phenethylamines, 3-benzazepines, and 9-(aminomethyl)fluorenes. J Med Chem. 1986 Oct;29(10):1904-12. DMNQWZO RU https://pubmed.ncbi.nlm.nih.gov/3761310 DM6Q3M7 DI DM6Q3M7 DM6Q3M7 DN 6-(2-Fluoro-4-hydroxy-phenyl)-naphthalen-2-ol DM6Q3M7 MI TTZAYWL DM6Q3M7 MN Estrogen receptor (ESR) DM6Q3M7 MT DTT DM6Q3M7 MA Inhibitor DM6Q3M7 RN ERbeta ligands. 3. Exploiting two binding orientations of the 2-phenylnaphthalene scaffold to achieve ERbeta selectivity. J Med Chem. 2005 Jun 16;48(12):3953-79. DM6Q3M7 RU https://pubmed.ncbi.nlm.nih.gov/15943471 DM6Q3M7 DI DM6Q3M7 DM6Q3M7 DN 6-(2-Fluoro-4-hydroxy-phenyl)-naphthalen-2-ol DM6Q3M7 MI TTOM3J0 DM6Q3M7 MN Estrogen receptor beta (ESR2) DM6Q3M7 MT DTT DM6Q3M7 MA Inhibitor DM6Q3M7 RN ERbeta ligands. 3. Exploiting two binding orientations of the 2-phenylnaphthalene scaffold to achieve ERbeta selectivity. J Med Chem. 2005 Jun 16;48(12):3953-79. DM6Q3M7 RU https://pubmed.ncbi.nlm.nih.gov/15943471 DMQKR2W DI DMQKR2W DMQKR2W DN 6-(2-Fluoro-benzenesulfonyl)-2H-pyridazin-3-one DMQKR2W MI TTFBNVI DMQKR2W MN Aldose reductase (AKR1B1) DMQKR2W MT DTT DMQKR2W MA Inhibitor DMQKR2W RN A novel series of non-carboxylic acid, non-hydantoin inhibitors of aldose reductase with potent oral activity in diabetic rat models: 6-(5-chloro-3... J Med Chem. 2005 Oct 6;48(20):6326-39. DMQKR2W RU https://pubmed.ncbi.nlm.nih.gov/16190759 DME1JLM DI DME1JLM DME1JLM DN 6-(2-Fluoropropyl)-4-methylpyridin-2-amine DME1JLM MI TTZUFI5 DME1JLM MN Nitric-oxide synthase brain (NOS1) DME1JLM MT DTT DME1JLM MA Inhibitor DME1JLM RN Design and synthesis of 2-amino-4-methylpyridine analogues as inhibitors for inducible nitric oxide synthase and in vivo evaluation of [18F]6-(2-fl... J Med Chem. 2009 Apr 23;52(8):2443-53. DME1JLM RU https://pubmed.ncbi.nlm.nih.gov/19323559 DME1JLM DI DME1JLM DME1JLM DN 6-(2-Fluoropropyl)-4-methylpyridin-2-amine DME1JLM MI TTCM4B3 DME1JLM MN Nitric-oxide synthase endothelial (NOS3) DME1JLM MT DTT DME1JLM MA Inhibitor DME1JLM RN Design and synthesis of 2-amino-4-methylpyridine analogues as inhibitors for inducible nitric oxide synthase and in vivo evaluation of [18F]6-(2-fl... J Med Chem. 2009 Apr 23;52(8):2443-53. DME1JLM RU https://pubmed.ncbi.nlm.nih.gov/19323559 DME1JLM DI DME1JLM DME1JLM DN 6-(2-Fluoropropyl)-4-methylpyridin-2-amine DME1JLM MI TTF10I9 DME1JLM MN Nitric-oxide synthase inducible (NOS2) DME1JLM MT DTT DME1JLM MA Inhibitor DME1JLM RN Design and synthesis of 2-amino-4-methylpyridine analogues as inhibitors for inducible nitric oxide synthase and in vivo evaluation of [18F]6-(2-fl... J Med Chem. 2009 Apr 23;52(8):2443-53. DME1JLM RU https://pubmed.ncbi.nlm.nih.gov/19323559 DMA2CPG DI DMA2CPG DMA2CPG DN 6-(2-HYDROXY-CYCLOPENTYL)-7-OXO-HEPTANAMIDINE DMA2CPG MI TT6L509 DMA2CPG MN Coagulation factor IIa (F2) DMA2CPG MT DTT DMA2CPG MA Inhibitor DMA2CPG RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DMA2CPG RU https://pubmed.ncbi.nlm.nih.gov/10592235 DMM3798 DI DMM3798 DMM3798 DN 6-(2-Hydroxy-phenyl)-naphthalen-2-ol DMM3798 MI TTOM3J0 DMM3798 MN Estrogen receptor beta (ESR2) DMM3798 MT DTT DMM3798 MA Inhibitor DMM3798 RN ERbeta ligands. 3. Exploiting two binding orientations of the 2-phenylnaphthalene scaffold to achieve ERbeta selectivity. J Med Chem. 2005 Jun 16;48(12):3953-79. DMM3798 RU https://pubmed.ncbi.nlm.nih.gov/15943471 DMXZWOA DI DMXZWOA DMXZWOA DN 6-(2-Imidazol-1-yl-vinyl)-1H-quinolin-2-one DMXZWOA MI TT06AWU DMXZWOA MN Phosphodiesterase 3A (PDE3A) DMXZWOA MT DTT DMXZWOA MA Inhibitor DMXZWOA RN 3,4-Dihydroquinolin-2(1H)-ones as combined inhibitors of thromboxane A2 synthase and cAMP phosphodiesterase. J Med Chem. 1992 Feb 21;35(4):620-8. DMXZWOA RU https://pubmed.ncbi.nlm.nih.gov/1311763 DM9P4LB DI DM9P4LB DM9P4LB DN 6-(2-mercaptoacetamido)-N-phenylhexanamide DM9P4LB MI TTT6LFV DM9P4LB MN Histone deacetylase 8 (HDAC8) DM9P4LB MT DTT DM9P4LB MA Inhibitor DM9P4LB RN Histone deacetylase inhibitors: from bench to clinic. J Med Chem. 2008 Mar 27;51(6):1505-29. DM9P4LB RU https://pubmed.ncbi.nlm.nih.gov/18247554 DMQOJBN DI DMQOJBN DMQOJBN DN 6-(2-phenethylisoindolin-5-yloxy)nicotinamide DMQOJBN MI TT27RFC DMQOJBN MN Opioid receptor delta (OPRD1) DMQOJBN MT DTT DMQOJBN MA Inhibitor DMQOJBN RN Structure activity relationship studies of carboxamido-biaryl ethers as opioid receptor antagonists (OpRAs). Part 2. Bioorg Med Chem Lett. 2007 Dec 15;17(24):6841-6. DMQOJBN RU https://pubmed.ncbi.nlm.nih.gov/17980586 DMQOJBN DI DMQOJBN DMQOJBN DN 6-(2-phenethylisoindolin-5-yloxy)nicotinamide DMQOJBN MI TTKWM86 DMQOJBN MN Opioid receptor mu (MOP) DMQOJBN MT DTT DMQOJBN MA Inhibitor DMQOJBN RN Structure activity relationship studies of carboxamido-biaryl ethers as opioid receptor antagonists (OpRAs). Part 2. Bioorg Med Chem Lett. 2007 Dec 15;17(24):6841-6. DMQOJBN RU https://pubmed.ncbi.nlm.nih.gov/17980586 DMKXNP0 DI DMKXNP0 DMKXNP0 DN 6-(2-Phenylsulfanyl-ethyl)-pteridine-2,4-diamine DMKXNP0 MI TT9SL3Q DMKXNP0 MN Polypeptide deformylase (PDF) DMKXNP0 MT DTT DMKXNP0 MA Inhibitor DMKXNP0 RN Further studies on 2,4-diamino-5-(2',5'-disubstituted benzyl)pyrimidines as potent and selective inhibitors of dihydrofolate reductases from three ... J Med Chem. 2003 Apr 24;46(9):1726-36. DMKXNP0 RU https://pubmed.ncbi.nlm.nih.gov/12699390 DMA8TWC DI DMA8TWC DMA8TWC DN 6-(3-(pyridin-4-yl)phenyl)naphthalen-2-ol DMA8TWC MI TTRA5BZ DMA8TWC MN Steroid 17-alpha-monooxygenase (S17AH) DMA8TWC MT DTT DMA8TWC MA Inhibitor DMA8TWC RN Synthesis, biological evaluation and molecular modelling studies of novel ACD- and ABD-ring steroidomimetics as inhibitors of CYP17. Bioorg Med Chem Lett. 2008 Jan 1;18(1):267-73. DMA8TWC RU https://pubmed.ncbi.nlm.nih.gov/18024111 DMDYQE2 DI DMDYQE2 DMDYQE2 DN 6-(3-(trifluoromethyl)phenyl)picolinonitrile DMDYQE2 MI TTUMQVO DMDYQE2 MN Cathepsin S (CTSS) DMDYQE2 MT DTT DMDYQE2 MA Inhibitor DMDYQE2 RN 4-(3-Trifluoromethylphenyl)-pyrimidine-2-carbonitrile as cathepsin S inhibitors: N3, not N1 is critically important. Bioorg Med Chem Lett. 2010 Aug 1;20(15):4507-10. DMDYQE2 RU https://pubmed.ncbi.nlm.nih.gov/20580231 DMZHFWX DI DMZHFWX DMZHFWX DN 6-(3,4-DICHLOROPHENYL)-1-[1-(METHYLOXY)-3-BUTEN-1-YL]-3-AZABICYCLO[4.1.0]HEPTANE (DIASTEREOMERIC MIX) DMZHFWX MI TTXV4FI DMZHFWX MN Albendazole monooxygenase (CYP3A4) DMZHFWX MT DTT DMZHFWX MA Inhibitor DMZHFWX RN 6-(3,4-dichlorophenyl)-1-[(methyloxy)methyl]-3-azabicyclo[4.1.0]heptane: a new potent and selective triple reuptake inhibitor. J Med Chem. 2010 Jul 8;53(13):4989-5001. DMZHFWX RU https://pubmed.ncbi.nlm.nih.gov/20527970 DMZHFWX DI DMZHFWX DMZHFWX DN 6-(3,4-DICHLOROPHENYL)-1-[1-(METHYLOXY)-3-BUTEN-1-YL]-3-AZABICYCLO[4.1.0]HEPTANE (DIASTEREOMERIC MIX) DMZHFWX MI TTVG215 DMZHFWX MN Debrisoquine 4-hydroxylase (CYP2D6) DMZHFWX MT DTT DMZHFWX MA Inhibitor DMZHFWX RN 6-(3,4-dichlorophenyl)-1-[(methyloxy)methyl]-3-azabicyclo[4.1.0]heptane: a new potent and selective triple reuptake inhibitor. J Med Chem. 2010 Jul 8;53(13):4989-5001. DMZHFWX RU https://pubmed.ncbi.nlm.nih.gov/20527970 DMKJOL6 DI DMKJOL6 DMKJOL6 DN 6-(3,5-Difluoro-4-hydroxy-phenyl)-naphthalen-2-ol DMKJOL6 MI TTZAYWL DMKJOL6 MN Estrogen receptor (ESR) DMKJOL6 MT DTT DMKJOL6 MA Inhibitor DMKJOL6 RN ERbeta ligands. 3. Exploiting two binding orientations of the 2-phenylnaphthalene scaffold to achieve ERbeta selectivity. J Med Chem. 2005 Jun 16;48(12):3953-79. DMKJOL6 RU https://pubmed.ncbi.nlm.nih.gov/15943471 DMKJOL6 DI DMKJOL6 DMKJOL6 DN 6-(3,5-Difluoro-4-hydroxy-phenyl)-naphthalen-2-ol DMKJOL6 MI TTOM3J0 DMKJOL6 MN Estrogen receptor beta (ESR2) DMKJOL6 MT DTT DMKJOL6 MA Inhibitor DMKJOL6 RN ERbeta ligands. 3. Exploiting two binding orientations of the 2-phenylnaphthalene scaffold to achieve ERbeta selectivity. J Med Chem. 2005 Jun 16;48(12):3953-79. DMKJOL6 RU https://pubmed.ncbi.nlm.nih.gov/15943471 DMIXT2L DI DMIXT2L DMIXT2L DN 6-(3,5-dimethoxy-phenyl)-naphthalen-2-ol DMIXT2L MI TT3OT40 DMIXT2L MN Multidrug resistance protein 1 (ABCB1) DMIXT2L MT DTT DMIXT2L MA Inhibitor DMIXT2L RN Identification of a terphenyl derivative that blocks the cell cycle in the G0-G1 phase and induces differentiation in leukemia cells. J Med Chem. 2006 May 18;49(10):3012-8. DMIXT2L RU https://pubmed.ncbi.nlm.nih.gov/16686543 DMJ92W0 DI DMJ92W0 DMJ92W0 DN 6-(3-Amino-benzyloxy)-9H-purin-2-ylamine DMJ92W0 MI TTAMQ62 DMJ92W0 MN Cyclin A2 (CCNA2) DMJ92W0 MT DTT DMJ92W0 MA Inhibitor DMJ92W0 RN Probing the ATP ribose-binding domain of cyclin-dependent kinases 1 and 2 with O(6)-substituted guanine derivatives. J Med Chem. 2002 Aug 1;45(16):3381-93. DMJ92W0 RU https://pubmed.ncbi.nlm.nih.gov/12139449 DMJ92W0 DI DMJ92W0 DMJ92W0 DN 6-(3-Amino-benzyloxy)-9H-purin-2-ylamine DMJ92W0 MI TT7HF4W DMJ92W0 MN Cyclin-dependent kinase 2 (CDK2) DMJ92W0 MT DTT DMJ92W0 MA Inhibitor DMJ92W0 RN Probing the ATP ribose-binding domain of cyclin-dependent kinases 1 and 2 with O(6)-substituted guanine derivatives. J Med Chem. 2002 Aug 1;45(16):3381-93. DMJ92W0 RU https://pubmed.ncbi.nlm.nih.gov/12139449 DMYA4D2 DI DMYA4D2 DMYA4D2 DN 6-(3-aminopropyl)benzo[h]isoquinolin-1(2H)-one DMYA4D2 MI TTTU902 DMYA4D2 MN Checkpoint kinase-1 (CHK1) DMYA4D2 MT DTT DMYA4D2 MA Inhibitor DMYA4D2 RN Synthesis and evaluation of substituted benzoisoquinolinones as potent inhibitors of Chk1 kinase. Bioorg Med Chem Lett. 2007 Nov 15;17(22):6280-5. DMYA4D2 RU https://pubmed.ncbi.nlm.nih.gov/17900896 DMKFDQ7 DI DMKFDQ7 DMKFDQ7 DN 6-(3-aza-bicyclo[3.1.0]hexan-1-yl)quinoline DMKFDQ7 MI TTVBI8W DMKFDQ7 MN Dopamine transporter (DAT) DMKFDQ7 MT DTT DMKFDQ7 MA Inhibitor DMKFDQ7 RN Studies on the structure-activity relationship of bicifadine analogs as monoamine transporter inhibitors. Bioorg Med Chem Lett. 2008 Jul 1;18(13):3682-6. DMKFDQ7 RU https://pubmed.ncbi.nlm.nih.gov/18539031 DMKFDQ7 DI DMKFDQ7 DMKFDQ7 DN 6-(3-aza-bicyclo[3.1.0]hexan-1-yl)quinoline DMKFDQ7 MI TT3ROYC DMKFDQ7 MN Serotonin transporter (SERT) DMKFDQ7 MT DTT DMKFDQ7 MA Inhibitor DMKFDQ7 RN Studies on the structure-activity relationship of bicifadine analogs as monoamine transporter inhibitors. Bioorg Med Chem Lett. 2008 Jul 1;18(13):3682-6. DMKFDQ7 RU https://pubmed.ncbi.nlm.nih.gov/18539031 DMQZTS3 DI DMQZTS3 DMQZTS3 DN 6-(3-Benzoyl-ureido)-hexanoic acid hydroxyamide DMQZTS3 MI TT6R7JZ DMQZTS3 MN Histone deacetylase 1 (HDAC1) DMQZTS3 MT DTT DMQZTS3 MA Inhibitor DMQZTS3 RN Acylurea connected straight chain hydroxamates as novel histone deacetylase inhibitors: Synthesis, SAR, and in vivo antitumor activity. Bioorg Med Chem Lett. 2010 Jun 1;20(11):3314-21. DMQZTS3 RU https://pubmed.ncbi.nlm.nih.gov/20451378 DM89LF5 DI DM89LF5 DM89LF5 DN 6-(3-BROMO-2-NAPHTHYL)-1,3,5-TRIAZINE-2,4-DIAMINE DM89LF5 MI TT78R5H DM89LF5 MN Heat shock protein 90 alpha (HSP90A) DM89LF5 MT DTT DM89LF5 MA Inhibitor DM89LF5 RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DM89LF5 RU https://pubmed.ncbi.nlm.nih.gov/10592235 DMMFWYX DI DMMFWYX DMMFWYX DN 6-(3-Bromo-phenylamino)-1H-pyrimidine-2,4-dione DMMFWYX MI TT2GPK3 DMMFWYX MN DNA topoisomerase (TOP) DMMFWYX MT DTT DMMFWYX MA Inhibitor DMMFWYX RN Inhibitors of Bacillus subtilis DNA polymerase III. 6-Anilinouracils and 6-(alkylamino)uracils. J Med Chem. 1980 Jan;23(1):34-8. DMMFWYX RU https://pubmed.ncbi.nlm.nih.gov/6767030 DM4YP3Q DI DM4YP3Q DM4YP3Q DN 6-(3-Chloro-4-hydroxy-phenyl)-naphthalen-2-ol DM4YP3Q MI TTZAYWL DM4YP3Q MN Estrogen receptor (ESR) DM4YP3Q MT DTT DM4YP3Q MA Inhibitor DM4YP3Q RN ERbeta ligands. 3. Exploiting two binding orientations of the 2-phenylnaphthalene scaffold to achieve ERbeta selectivity. J Med Chem. 2005 Jun 16;48(12):3953-79. DM4YP3Q RU https://pubmed.ncbi.nlm.nih.gov/15943471 DM4YP3Q DI DM4YP3Q DM4YP3Q DN 6-(3-Chloro-4-hydroxy-phenyl)-naphthalen-2-ol DM4YP3Q MI TTOM3J0 DM4YP3Q MN Estrogen receptor beta (ESR2) DM4YP3Q MT DTT DM4YP3Q MA Inhibitor DM4YP3Q RN ERbeta ligands. 3. Exploiting two binding orientations of the 2-phenylnaphthalene scaffold to achieve ERbeta selectivity. J Med Chem. 2005 Jun 16;48(12):3953-79. DM4YP3Q RU https://pubmed.ncbi.nlm.nih.gov/15943471 DMJO4I7 DI DMJO4I7 DMJO4I7 DN 6-(3-Chloro-benzenesulfonyl)-2H-pyridazin-3-one DMJO4I7 MI TTFBNVI DMJO4I7 MN Aldose reductase (AKR1B1) DMJO4I7 MT DTT DMJO4I7 MA Inhibitor DMJO4I7 RN A novel series of non-carboxylic acid, non-hydantoin inhibitors of aldose reductase with potent oral activity in diabetic rat models: 6-(5-chloro-3... J Med Chem. 2005 Oct 6;48(20):6326-39. DMJO4I7 RU https://pubmed.ncbi.nlm.nih.gov/16190759 DMKUHN9 DI DMKUHN9 DMKUHN9 DN 6-(3-Ethyl-phenylamino)-1H-pyrimidine-2,4-dione DMKUHN9 MI TT2GPK3 DMKUHN9 MN DNA topoisomerase (TOP) DMKUHN9 MT DTT DMKUHN9 MA Inhibitor DMKUHN9 RN Inhibitors of Bacillus subtilis DNA polymerase III. 6-Anilinouracils and 6-(alkylamino)uracils. J Med Chem. 1980 Jan;23(1):34-8. DMKUHN9 RU https://pubmed.ncbi.nlm.nih.gov/6767030 DMKUHN9 DI DMKUHN9 DMKUHN9 DN 6-(3-Ethyl-phenylamino)-1H-pyrimidine-2,4-dione DMKUHN9 MI TTIU7X1 DMKUHN9 MN Herpes simplex virus DNA polymerase UL30 (HSV UL30) DMKUHN9 MT DTT DMKUHN9 MA Inhibitor DMKUHN9 RN Inhibitors of Bacillus subtilis DNA polymerase III. 6-Anilinouracils and 6-(alkylamino)uracils. J Med Chem. 1980 Jan;23(1):34-8. DMKUHN9 RU https://pubmed.ncbi.nlm.nih.gov/6767030 DMAJEDG DI DMAJEDG DMAJEDG DN 6-(3-Fluoro-4-hydroxy-phenyl)-naphthalen-2-ol DMAJEDG MI TTZAYWL DMAJEDG MN Estrogen receptor (ESR) DMAJEDG MT DTT DMAJEDG MA Inhibitor DMAJEDG RN ERbeta ligands. 3. Exploiting two binding orientations of the 2-phenylnaphthalene scaffold to achieve ERbeta selectivity. J Med Chem. 2005 Jun 16;48(12):3953-79. DMAJEDG RU https://pubmed.ncbi.nlm.nih.gov/15943471 DMAJEDG DI DMAJEDG DMAJEDG DN 6-(3-Fluoro-4-hydroxy-phenyl)-naphthalen-2-ol DMAJEDG MI TTOM3J0 DMAJEDG MN Estrogen receptor beta (ESR2) DMAJEDG MT DTT DMAJEDG MA Inhibitor DMAJEDG RN ERbeta ligands. 3. Exploiting two binding orientations of the 2-phenylnaphthalene scaffold to achieve ERbeta selectivity. J Med Chem. 2005 Jun 16;48(12):3953-79. DMAJEDG RU https://pubmed.ncbi.nlm.nih.gov/15943471 DMTJPZU DI DMTJPZU DMTJPZU DN 6-(3-Fluoropropyl)-4-methylpyridin-2-amine DMTJPZU MI TTZUFI5 DMTJPZU MN Nitric-oxide synthase brain (NOS1) DMTJPZU MT DTT DMTJPZU MA Inhibitor DMTJPZU RN Design and synthesis of 2-amino-4-methylpyridine analogues as inhibitors for inducible nitric oxide synthase and in vivo evaluation of [18F]6-(2-fl... J Med Chem. 2009 Apr 23;52(8):2443-53. DMTJPZU RU https://pubmed.ncbi.nlm.nih.gov/19323559 DMTJPZU DI DMTJPZU DMTJPZU DN 6-(3-Fluoropropyl)-4-methylpyridin-2-amine DMTJPZU MI TTCM4B3 DMTJPZU MN Nitric-oxide synthase endothelial (NOS3) DMTJPZU MT DTT DMTJPZU MA Inhibitor DMTJPZU RN Design and synthesis of 2-amino-4-methylpyridine analogues as inhibitors for inducible nitric oxide synthase and in vivo evaluation of [18F]6-(2-fl... J Med Chem. 2009 Apr 23;52(8):2443-53. DMTJPZU RU https://pubmed.ncbi.nlm.nih.gov/19323559 DMTJPZU DI DMTJPZU DMTJPZU DN 6-(3-Fluoropropyl)-4-methylpyridin-2-amine DMTJPZU MI TTF10I9 DMTJPZU MN Nitric-oxide synthase inducible (NOS2) DMTJPZU MT DTT DMTJPZU MA Inhibitor DMTJPZU RN Design and synthesis of 2-amino-4-methylpyridine analogues as inhibitors for inducible nitric oxide synthase and in vivo evaluation of [18F]6-(2-fl... J Med Chem. 2009 Apr 23;52(8):2443-53. DMTJPZU RU https://pubmed.ncbi.nlm.nih.gov/19323559 DMMZENV DI DMMZENV DMMZENV DN 6-(3-Hydroxyphenyl)-1-phenyl-2-naphthol DMMZENV MI TTIWB6L DMMZENV MN Estradiol 17 beta-dehydrogenase 1 (17-beta-HSD1) DMMZENV MT DTT DMMZENV MA Inhibitor DMMZENV RN Substituted 6-phenyl-2-naphthols. Potent and selective nonsteroidal inhibitors of 17beta-hydroxysteroid dehydrogenase type 1 (17beta-HSD1): design,... J Med Chem. 2008 Aug 14;51(15):4685-98. DMMZENV RU https://pubmed.ncbi.nlm.nih.gov/18630892 DM28DPY DI DM28DPY DM28DPY DN 6-(3-hydroxyphenyl)-2-morpholino-4H-chromen-4-one DM28DPY MI TTK3PY9 DM28DPY MN DNA-dependent protein kinase catalytic (PRKDC) DM28DPY MT DTT DM28DPY MA Inhibitor DM28DPY RN Discovery of potent chromen-4-one inhibitors of the DNA-dependent protein kinase (DNA-PK) using a small-molecule library approach. J Med Chem. 2005 Dec 1;48(24):7829-46. DM28DPY RU https://pubmed.ncbi.nlm.nih.gov/16302822 DMMHRVO DI DMMHRVO DMMHRVO DN 6-(3-Hydroxy-phenyl)-naphthalen-1-ol DMMHRVO MI TTZAYWL DMMHRVO MN Estrogen receptor (ESR) DMMHRVO MT DTT DMMHRVO MA Inhibitor DMMHRVO RN ERbeta ligands. 3. Exploiting two binding orientations of the 2-phenylnaphthalene scaffold to achieve ERbeta selectivity. J Med Chem. 2005 Jun 16;48(12):3953-79. DMMHRVO RU https://pubmed.ncbi.nlm.nih.gov/15943471 DMMHRVO DI DMMHRVO DMMHRVO DN 6-(3-Hydroxy-phenyl)-naphthalen-1-ol DMMHRVO MI TTOM3J0 DMMHRVO MN Estrogen receptor beta (ESR2) DMMHRVO MT DTT DMMHRVO MA Inhibitor DMMHRVO RN ERbeta ligands. 3. Exploiting two binding orientations of the 2-phenylnaphthalene scaffold to achieve ERbeta selectivity. J Med Chem. 2005 Jun 16;48(12):3953-79. DMMHRVO RU https://pubmed.ncbi.nlm.nih.gov/15943471 DMH8WA2 DI DMH8WA2 DMH8WA2 DN 6-(3-Hydroxy-phenyl)-naphthalen-2-ol DMH8WA2 MI TTXV4FI DMH8WA2 MN Albendazole monooxygenase (CYP3A4) DMH8WA2 MT DTT DMH8WA2 MA Inhibitor DMH8WA2 RN Design, synthesis, and biological evaluation of (hydroxyphenyl)naphthalene and -quinoline derivatives: potent and selective nonsteroidal inhibitors... J Med Chem. 2008 Apr 10;51(7):2158-69. DMH8WA2 RU https://pubmed.ncbi.nlm.nih.gov/18324762 DMH8WA2 DI DMH8WA2 DMH8WA2 DN 6-(3-Hydroxy-phenyl)-naphthalen-2-ol DMH8WA2 MI TTIWB6L DMH8WA2 MN Estradiol 17 beta-dehydrogenase 1 (17-beta-HSD1) DMH8WA2 MT DTT DMH8WA2 MA Inhibitor DMH8WA2 RN Substituted 6-phenyl-2-naphthols. Potent and selective nonsteroidal inhibitors of 17beta-hydroxysteroid dehydrogenase type 1 (17beta-HSD1): design,... J Med Chem. 2008 Aug 14;51(15):4685-98. DMH8WA2 RU https://pubmed.ncbi.nlm.nih.gov/18630892 DMH8WA2 DI DMH8WA2 DMH8WA2 DN 6-(3-Hydroxy-phenyl)-naphthalen-2-ol DMH8WA2 MI TTZAYWL DMH8WA2 MN Estrogen receptor (ESR) DMH8WA2 MT DTT DMH8WA2 MA Inhibitor DMH8WA2 RN ERbeta ligands. 3. Exploiting two binding orientations of the 2-phenylnaphthalene scaffold to achieve ERbeta selectivity. J Med Chem. 2005 Jun 16;48(12):3953-79. DMH8WA2 RU https://pubmed.ncbi.nlm.nih.gov/15943471 DMH8WA2 DI DMH8WA2 DMH8WA2 DN 6-(3-Hydroxy-phenyl)-naphthalen-2-ol DMH8WA2 MI TTOM3J0 DMH8WA2 MN Estrogen receptor beta (ESR2) DMH8WA2 MT DTT DMH8WA2 MA Inhibitor DMH8WA2 RN ERbeta ligands. 3. Exploiting two binding orientations of the 2-phenylnaphthalene scaffold to achieve ERbeta selectivity. J Med Chem. 2005 Jun 16;48(12):3953-79. DMH8WA2 RU https://pubmed.ncbi.nlm.nih.gov/15943471 DMH8WA2 DI DMH8WA2 DMH8WA2 DN 6-(3-Hydroxy-phenyl)-naphthalen-2-ol DMH8WA2 MI TTULVH8 DMH8WA2 MN Tyrosinase (TYR) DMH8WA2 MT DTT DMH8WA2 MA Inhibitor DMH8WA2 RN Syntheses of hydroxy substituted 2-phenyl-naphthalenes as inhibitors of tyrosinase. Bioorg Med Chem Lett. 2007 Jan 15;17(2):461-4. DMH8WA2 RU https://pubmed.ncbi.nlm.nih.gov/17064896 DMISV5A DI DMISV5A DMISV5A DN 6-(3-Iodo-phenylamino)-1H-pyrimidine-2,4-dione DMISV5A MI TT2GPK3 DMISV5A MN DNA topoisomerase (TOP) DMISV5A MT DTT DMISV5A MA Inhibitor DMISV5A RN Inhibitors of Bacillus subtilis DNA polymerase III. 6-Anilinouracils and 6-(alkylamino)uracils. J Med Chem. 1980 Jan;23(1):34-8. DMISV5A RU https://pubmed.ncbi.nlm.nih.gov/6767030 DMSW3KN DI DMSW3KN DMSW3KN DN 6-(3-Methyl-benzyloxy)-9H-purin-2-ylamine DMSW3KN MI TTAMQ62 DMSW3KN MN Cyclin A2 (CCNA2) DMSW3KN MT DTT DMSW3KN MA Inhibitor DMSW3KN RN Probing the ATP ribose-binding domain of cyclin-dependent kinases 1 and 2 with O(6)-substituted guanine derivatives. J Med Chem. 2002 Aug 1;45(16):3381-93. DMSW3KN RU https://pubmed.ncbi.nlm.nih.gov/12139449 DMSW3KN DI DMSW3KN DMSW3KN DN 6-(3-Methyl-benzyloxy)-9H-purin-2-ylamine DMSW3KN MI TT7HF4W DMSW3KN MN Cyclin-dependent kinase 2 (CDK2) DMSW3KN MT DTT DMSW3KN MA Inhibitor DMSW3KN RN Probing the ATP ribose-binding domain of cyclin-dependent kinases 1 and 2 with O(6)-substituted guanine derivatives. J Med Chem. 2002 Aug 1;45(16):3381-93. DMSW3KN RU https://pubmed.ncbi.nlm.nih.gov/12139449 DM83VN6 DI DM83VN6 DM83VN6 DN 6-(3-Nitro-phenyl)-3H-benzothiazol-2-one DM83VN6 MI TTUV8G9 DM83VN6 MN Progesterone receptor (PGR) DM83VN6 MT DTT DM83VN6 MA Inhibitor DM83VN6 RN Synthesis and structure-activity relationship of novel 6-aryl-1,4-dihydrobenzo[d][1,3]oxazine-2-thiones as progesterone receptor modulators leading... J Med Chem. 2005 Aug 11;48(16):5092-5. DM83VN6 RU https://pubmed.ncbi.nlm.nih.gov/16078826 DMEM1BA DI DMEM1BA DMEM1BA DN 6-(4-((benzylamino)methyl)phenoxy)nicotinamide DMEM1BA MI TT27RFC DMEM1BA MN Opioid receptor delta (OPRD1) DMEM1BA MT DTT DMEM1BA MA Inhibitor DMEM1BA RN Structure-activity relationship studies of carboxamido-biaryl ethers as opioid receptor antagonists (OpRAs). Part 1. Bioorg Med Chem Lett. 2007 Oct 1;17(19):5349-52. DMEM1BA RU https://pubmed.ncbi.nlm.nih.gov/17720493 DMEM1BA DI DMEM1BA DMEM1BA DN 6-(4-((benzylamino)methyl)phenoxy)nicotinamide DMEM1BA MI TTQW87Y DMEM1BA MN Opioid receptor kappa (OPRK1) DMEM1BA MT DTT DMEM1BA MA Inhibitor DMEM1BA RN Structure-activity relationship studies of carboxamido-biaryl ethers as opioid receptor antagonists (OpRAs). Part 1. Bioorg Med Chem Lett. 2007 Oct 1;17(19):5349-52. DMEM1BA RU https://pubmed.ncbi.nlm.nih.gov/17720493 DMEM1BA DI DMEM1BA DMEM1BA DN 6-(4-((benzylamino)methyl)phenoxy)nicotinamide DMEM1BA MI TTKWM86 DMEM1BA MN Opioid receptor mu (MOP) DMEM1BA MT DTT DMEM1BA MA Inhibitor DMEM1BA RN Structure-activity relationship studies of carboxamido-biaryl ethers as opioid receptor antagonists (OpRAs). Part 1. Bioorg Med Chem Lett. 2007 Oct 1;17(19):5349-52. DMEM1BA RU https://pubmed.ncbi.nlm.nih.gov/17720493 DM9VD4W DI DM9VD4W DM9VD4W DN 6-(4-((phenethylamino)methyl)phenoxy)nicotinamide DM9VD4W MI TT27RFC DM9VD4W MN Opioid receptor delta (OPRD1) DM9VD4W MT DTT DM9VD4W MA Inhibitor DM9VD4W RN Structure activity relationship studies of carboxamido-biaryl ethers as opioid receptor antagonists (OpRAs). Part 2. Bioorg Med Chem Lett. 2007 Dec 15;17(24):6841-6. DM9VD4W RU https://pubmed.ncbi.nlm.nih.gov/17980586 DM9VD4W DI DM9VD4W DM9VD4W DN 6-(4-((phenethylamino)methyl)phenoxy)nicotinamide DM9VD4W MI TTQW87Y DM9VD4W MN Opioid receptor kappa (OPRK1) DM9VD4W MT DTT DM9VD4W MA Inhibitor DM9VD4W RN Structure activity relationship studies of carboxamido-biaryl ethers as opioid receptor antagonists (OpRAs). Part 2. Bioorg Med Chem Lett. 2007 Dec 15;17(24):6841-6. DM9VD4W RU https://pubmed.ncbi.nlm.nih.gov/17980586 DM9VD4W DI DM9VD4W DM9VD4W DN 6-(4-((phenethylamino)methyl)phenoxy)nicotinamide DM9VD4W MI TTKWM86 DM9VD4W MN Opioid receptor mu (MOP) DM9VD4W MT DTT DM9VD4W MA Inhibitor DM9VD4W RN Structure activity relationship studies of carboxamido-biaryl ethers as opioid receptor antagonists (OpRAs). Part 2. Bioorg Med Chem Lett. 2007 Dec 15;17(24):6841-6. DM9VD4W RU https://pubmed.ncbi.nlm.nih.gov/17980586 DMDKOWP DI DMDKOWP DMDKOWP DN 6-(4-(2-(benzylamino)ethyl)phenoxy)nicotinamide DMDKOWP MI TT27RFC DMDKOWP MN Opioid receptor delta (OPRD1) DMDKOWP MT DTT DMDKOWP MA Inhibitor DMDKOWP RN Structure activity relationship studies of carboxamido-biaryl ethers as opioid receptor antagonists (OpRAs). Part 2. Bioorg Med Chem Lett. 2007 Dec 15;17(24):6841-6. DMDKOWP RU https://pubmed.ncbi.nlm.nih.gov/17980586 DMDKOWP DI DMDKOWP DMDKOWP DN 6-(4-(2-(benzylamino)ethyl)phenoxy)nicotinamide DMDKOWP MI TTQW87Y DMDKOWP MN Opioid receptor kappa (OPRK1) DMDKOWP MT DTT DMDKOWP MA Inhibitor DMDKOWP RN Structure activity relationship studies of carboxamido-biaryl ethers as opioid receptor antagonists (OpRAs). Part 2. Bioorg Med Chem Lett. 2007 Dec 15;17(24):6841-6. DMDKOWP RU https://pubmed.ncbi.nlm.nih.gov/17980586 DMDKOWP DI DMDKOWP DMDKOWP DN 6-(4-(2-(benzylamino)ethyl)phenoxy)nicotinamide DMDKOWP MI TTKWM86 DMDKOWP MN Opioid receptor mu (MOP) DMDKOWP MT DTT DMDKOWP MA Inhibitor DMDKOWP RN Structure activity relationship studies of carboxamido-biaryl ethers as opioid receptor antagonists (OpRAs). Part 2. Bioorg Med Chem Lett. 2007 Dec 15;17(24):6841-6. DMDKOWP RU https://pubmed.ncbi.nlm.nih.gov/17980586 DMOSDM2 DI DMOSDM2 DMOSDM2 DN 6-(4-(2-(benzylamino)ethyl)phenoxy)picolinamide DMOSDM2 MI TTKWM86 DMOSDM2 MN Opioid receptor mu (MOP) DMOSDM2 MT DTT DMOSDM2 MA Inhibitor DMOSDM2 RN Structure-activity relationship studies of carboxamido-biaryl ethers as opioid receptor antagonists (OpRAs). Part 1. Bioorg Med Chem Lett. 2007 Oct 1;17(19):5349-52. DMOSDM2 RU https://pubmed.ncbi.nlm.nih.gov/17720493 DMDTMB7 DI DMDTMB7 DMDTMB7 DN 6-(4-(3-(benzylamino)propyl)phenoxy)nicotinamide DMDTMB7 MI TT27RFC DMDTMB7 MN Opioid receptor delta (OPRD1) DMDTMB7 MT DTT DMDTMB7 MA Inhibitor DMDTMB7 RN Structure-activity relationship studies of carboxamido-biaryl ethers as opioid receptor antagonists (OpRAs). Part 1. Bioorg Med Chem Lett. 2007 Oct 1;17(19):5349-52. DMDTMB7 RU https://pubmed.ncbi.nlm.nih.gov/17720493 DMDTMB7 DI DMDTMB7 DMDTMB7 DN 6-(4-(3-(benzylamino)propyl)phenoxy)nicotinamide DMDTMB7 MI TTQW87Y DMDTMB7 MN Opioid receptor kappa (OPRK1) DMDTMB7 MT DTT DMDTMB7 MA Inhibitor DMDTMB7 RN Structure-activity relationship studies of carboxamido-biaryl ethers as opioid receptor antagonists (OpRAs). Part 1. Bioorg Med Chem Lett. 2007 Oct 1;17(19):5349-52. DMDTMB7 RU https://pubmed.ncbi.nlm.nih.gov/17720493 DMDTMB7 DI DMDTMB7 DMDTMB7 DN 6-(4-(3-(benzylamino)propyl)phenoxy)nicotinamide DMDTMB7 MI TTKWM86 DMDTMB7 MN Opioid receptor mu (MOP) DMDTMB7 MT DTT DMDTMB7 MA Inhibitor DMDTMB7 RN Structure-activity relationship studies of carboxamido-biaryl ethers as opioid receptor antagonists (OpRAs). Part 1. Bioorg Med Chem Lett. 2007 Oct 1;17(19):5349-52. DMDTMB7 RU https://pubmed.ncbi.nlm.nih.gov/17720493 DM9K8DY DI DM9K8DY DM9K8DY DN 6-(4-Bromo-benzenesulfonyl)-2H-pyridazin-3-one DM9K8DY MI TTFBNVI DM9K8DY MN Aldose reductase (AKR1B1) DM9K8DY MT DTT DM9K8DY MA Inhibitor DM9K8DY RN A novel series of non-carboxylic acid, non-hydantoin inhibitors of aldose reductase with potent oral activity in diabetic rat models: 6-(5-chloro-3... J Med Chem. 2005 Oct 6;48(20):6326-39. DM9K8DY RU https://pubmed.ncbi.nlm.nih.gov/16190759 DMCYQDU DI DMCYQDU DMCYQDU DN 6-(4-Bromo-phenylamino)-1H-pyrimidine-2,4-dione DMCYQDU MI TTIU7X1 DMCYQDU MN Herpes simplex virus DNA polymerase UL30 (HSV UL30) DMCYQDU MT DTT DMCYQDU MA Inhibitor DMCYQDU RN Inhibitors of Bacillus subtilis DNA polymerase III. 6-Anilinouracils and 6-(alkylamino)uracils. J Med Chem. 1980 Jan;23(1):34-8. DMCYQDU RU https://pubmed.ncbi.nlm.nih.gov/6767030 DMNAHVB DI DMNAHVB DMNAHVB DN 6-(4-Chloro-benzenesulfonyl)-2H-pyridazin-3-one DMNAHVB MI TTFBNVI DMNAHVB MN Aldose reductase (AKR1B1) DMNAHVB MT DTT DMNAHVB MA Inhibitor DMNAHVB RN A novel series of non-carboxylic acid, non-hydantoin inhibitors of aldose reductase with potent oral activity in diabetic rat models: 6-(5-chloro-3... J Med Chem. 2005 Oct 6;48(20):6326-39. DMNAHVB RU https://pubmed.ncbi.nlm.nih.gov/16190759 DMSO2JW DI DMSO2JW DMSO2JW DN 6-(4-chlorophenyl)-2-morpholin-4-ylpyridin-4-ol DMSO2JW MI TTK3PY9 DMSO2JW MN DNA-dependent protein kinase catalytic (PRKDC) DMSO2JW MT DTT DMSO2JW MA Inhibitor DMSO2JW RN Pyranone, thiopyranone, and pyridone inhibitors of phosphatidylinositol 3-kinase related kinases. Structure-activity relationships for DNA-dependen... J Med Chem. 2007 Apr 19;50(8):1958-72. DMSO2JW RU https://pubmed.ncbi.nlm.nih.gov/17371003 DMMTG7L DI DMMTG7L DMMTG7L DN 6-(4-chlorophenyl)-4-morpholino-2H-pyran-2-one DMMTG7L MI TTK3PY9 DMMTG7L MN DNA-dependent protein kinase catalytic (PRKDC) DMMTG7L MT DTT DMMTG7L MA Inhibitor DMMTG7L RN Pyranone, thiopyranone, and pyridone inhibitors of phosphatidylinositol 3-kinase related kinases. Structure-activity relationships for DNA-dependen... J Med Chem. 2007 Apr 19;50(8):1958-72. DMMTG7L RU https://pubmed.ncbi.nlm.nih.gov/17371003 DM0C1FX DI DM0C1FX DM0C1FX DN 6-(4-CHLOROPHENYL)-7-(2,4-DICHLOROPHENYL)-2,2-DIMETHYL-3,4-DIHYDRO-2H-PYRANO[2,3-B]PYRIDINE-4-CARBOXAMIDE (ENANTIOMERIC MIX) DM0C1FX MI TT6OEDT DM0C1FX MN Cannabinoid receptor 1 (CB1) DM0C1FX MT DTT DM0C1FX MA Inhibitor DM0C1FX RN Dihydro-pyrano[2,3-b]pyridines and tetrahydro-1,8-naphthyridines as CB1 receptor inverse agonists: synthesis, SAR and biological evaluation. Bioorg Med Chem Lett. 2010 Jun 15;20(12):3750-4. DM0C1FX RU https://pubmed.ncbi.nlm.nih.gov/20483606 DM0C1FX DI DM0C1FX DM0C1FX DN 6-(4-CHLOROPHENYL)-7-(2,4-DICHLOROPHENYL)-2,2-DIMETHYL-3,4-DIHYDRO-2H-PYRANO[2,3-B]PYRIDINE-4-CARBOXAMIDE (ENANTIOMERIC MIX) DM0C1FX MI TTMSFAW DM0C1FX MN Cannabinoid receptor 2 (CB2) DM0C1FX MT DTT DM0C1FX MA Inhibitor DM0C1FX RN Dihydro-pyrano[2,3-b]pyridines and tetrahydro-1,8-naphthyridines as CB1 receptor inverse agonists: synthesis, SAR and biological evaluation. Bioorg Med Chem Lett. 2010 Jun 15;20(12):3750-4. DM0C1FX RU https://pubmed.ncbi.nlm.nih.gov/20483606 DM1N46J DI DM1N46J DM1N46J DN 6-(4-CHLOROPHENYL)-7-(2,4-DICHLOROPHENYL)-N-((R)-1-HYDROXYETHYL)-1,2,2-TRIMETHYL-1,2,3,4-TETRAHYDRO-1,8-NAPHTHYRIDINE-4-CARBOXAMIDE (ENANTIOMERIC MIX) DM1N46J MI TT6OEDT DM1N46J MN Cannabinoid receptor 1 (CB1) DM1N46J MT DTT DM1N46J MA Inhibitor DM1N46J RN Dihydro-pyrano[2,3-b]pyridines and tetrahydro-1,8-naphthyridines as CB1 receptor inverse agonists: synthesis, SAR and biological evaluation. Bioorg Med Chem Lett. 2010 Jun 15;20(12):3750-4. DM1N46J RU https://pubmed.ncbi.nlm.nih.gov/20483606 DM1N46J DI DM1N46J DM1N46J DN 6-(4-CHLOROPHENYL)-7-(2,4-DICHLOROPHENYL)-N-((R)-1-HYDROXYETHYL)-1,2,2-TRIMETHYL-1,2,3,4-TETRAHYDRO-1,8-NAPHTHYRIDINE-4-CARBOXAMIDE (ENANTIOMERIC MIX) DM1N46J MI TTMSFAW DM1N46J MN Cannabinoid receptor 2 (CB2) DM1N46J MT DTT DM1N46J MA Inhibitor DM1N46J RN Dihydro-pyrano[2,3-b]pyridines and tetrahydro-1,8-naphthyridines as CB1 receptor inverse agonists: synthesis, SAR and biological evaluation. Bioorg Med Chem Lett. 2010 Jun 15;20(12):3750-4. DM1N46J RU https://pubmed.ncbi.nlm.nih.gov/20483606 DM5H4KE DI DM5H4KE DM5H4KE DN 6-(4-CHLOROPHENYL)-7-(2,4-DICHLOROPHENYL)-N-(1-HYDROXY-2-METHYLPROPAN-2-YL)-2,2-DIMETHYL-3,4-DIHYDRO-2H-PYRANO[2,3-B]PYRIDINE-4-CARBOXAMIDE (ENANTIOMERIC MIX) DM5H4KE MI TT6OEDT DM5H4KE MN Cannabinoid receptor 1 (CB1) DM5H4KE MT DTT DM5H4KE MA Inhibitor DM5H4KE RN Dihydro-pyrano[2,3-b]pyridines and tetrahydro-1,8-naphthyridines as CB1 receptor inverse agonists: synthesis, SAR and biological evaluation. Bioorg Med Chem Lett. 2010 Jun 15;20(12):3750-4. DM5H4KE RU https://pubmed.ncbi.nlm.nih.gov/20483606 DM5H4KE DI DM5H4KE DM5H4KE DN 6-(4-CHLOROPHENYL)-7-(2,4-DICHLOROPHENYL)-N-(1-HYDROXY-2-METHYLPROPAN-2-YL)-2,2-DIMETHYL-3,4-DIHYDRO-2H-PYRANO[2,3-B]PYRIDINE-4-CARBOXAMIDE (ENANTIOMERIC MIX) DM5H4KE MI TTMSFAW DM5H4KE MN Cannabinoid receptor 2 (CB2) DM5H4KE MT DTT DM5H4KE MA Inhibitor DM5H4KE RN Dihydro-pyrano[2,3-b]pyridines and tetrahydro-1,8-naphthyridines as CB1 receptor inverse agonists: synthesis, SAR and biological evaluation. Bioorg Med Chem Lett. 2010 Jun 15;20(12):3750-4. DM5H4KE RU https://pubmed.ncbi.nlm.nih.gov/20483606 DMEJ83H DI DMEJ83H DMEJ83H DN 6-(4-CHLOROPHENYL)-7-(2,4-DICHLOROPHENYL)-N-(HYDROXYMETHYL)-1,2,2-TRIMETHYL-1,2,3,4-TETRAHYDRO-1,8-NAPHTHYRIDINE-4-CARBOXAMIDE (ENANTIOMERIC MIX) DMEJ83H MI TT6OEDT DMEJ83H MN Cannabinoid receptor 1 (CB1) DMEJ83H MT DTT DMEJ83H MA Inhibitor DMEJ83H RN Dihydro-pyrano[2,3-b]pyridines and tetrahydro-1,8-naphthyridines as CB1 receptor inverse agonists: synthesis, SAR and biological evaluation. Bioorg Med Chem Lett. 2010 Jun 15;20(12):3750-4. DMEJ83H RU https://pubmed.ncbi.nlm.nih.gov/20483606 DMEJ83H DI DMEJ83H DMEJ83H DN 6-(4-CHLOROPHENYL)-7-(2,4-DICHLOROPHENYL)-N-(HYDROXYMETHYL)-1,2,2-TRIMETHYL-1,2,3,4-TETRAHYDRO-1,8-NAPHTHYRIDINE-4-CARBOXAMIDE (ENANTIOMERIC MIX) DMEJ83H MI TTMSFAW DMEJ83H MN Cannabinoid receptor 2 (CB2) DMEJ83H MT DTT DMEJ83H MA Inhibitor DMEJ83H RN Dihydro-pyrano[2,3-b]pyridines and tetrahydro-1,8-naphthyridines as CB1 receptor inverse agonists: synthesis, SAR and biological evaluation. Bioorg Med Chem Lett. 2010 Jun 15;20(12):3750-4. DMEJ83H RU https://pubmed.ncbi.nlm.nih.gov/20483606 DMEJ83H DI DMEJ83H DMEJ83H DN 6-(4-CHLOROPHENYL)-7-(2,4-DICHLOROPHENYL)-N-(HYDROXYMETHYL)-1,2,2-TRIMETHYL-1,2,3,4-TETRAHYDRO-1,8-NAPHTHYRIDINE-4-CARBOXAMIDE (ENANTIOMERIC MIX) DMEJ83H MI TTQ6VDM DMEJ83H MN Voltage-gated potassium channel Kv11.1 (KCNH2) DMEJ83H MT DTT DMEJ83H MA Inhibitor DMEJ83H RN Dihydro-pyrano[2,3-b]pyridines and tetrahydro-1,8-naphthyridines as CB1 receptor inverse agonists: synthesis, SAR and biological evaluation. Bioorg Med Chem Lett. 2010 Jun 15;20(12):3750-4. DMEJ83H RU https://pubmed.ncbi.nlm.nih.gov/20483606 DM5LUF4 DI DM5LUF4 DM5LUF4 DN 6-(4-Chloro-phenylamino)-1H-pyrimidine-2,4-dione DM5LUF4 MI TTIU7X1 DM5LUF4 MN Herpes simplex virus DNA polymerase UL30 (HSV UL30) DM5LUF4 MT DTT DM5LUF4 MA Inhibitor DM5LUF4 RN Inhibitors of Bacillus subtilis DNA polymerase III. 6-Anilinouracils and 6-(alkylamino)uracils. J Med Chem. 1980 Jan;23(1):34-8. DM5LUF4 RU https://pubmed.ncbi.nlm.nih.gov/6767030 DMOZFU5 DI DMOZFU5 DMOZFU5 DN 6-(4-chlorophenylamino)-N,N-diethylnicotinamide DMOZFU5 MI TTHS256 DMOZFU5 MN Metabotropic glutamate receptor 5 (mGluR5) DMOZFU5 MT DTT DMOZFU5 MA Inhibitor DMOZFU5 RN Piperidyl amides as novel, potent and orally active mGlu5 receptor antagonists with anxiolytic-like activity. Bioorg Med Chem Lett. 2010 Jan 1;20(1):184-8. DMOZFU5 RU https://pubmed.ncbi.nlm.nih.gov/19931453 DMYQB5R DI DMYQB5R DMYQB5R DN 6-(4-Decyloxy-phenyl)-1,1,1-trifluoro-hexan-2-one DMYQB5R MI TTT1JVS DMYQB5R MN Cytosolic phospholipase A2 (GIVA cPLA2) DMYQB5R MT DTT DMYQB5R MA Inhibitor DMYQB5R RN Synthesis of polyfluoro ketones for selective inhibition of human phospholipase A2 enzymes. J Med Chem. 2008 Dec 25;51(24):8027-37. DMYQB5R RU https://pubmed.ncbi.nlm.nih.gov/19053783 DM7WYNT DI DM7WYNT DM7WYNT DN 6-(4-Fluoro-benzenesulfonyl)-2H-pyridazin-3-one DM7WYNT MI TTFBNVI DM7WYNT MN Aldose reductase (AKR1B1) DM7WYNT MT DTT DM7WYNT MA Inhibitor DM7WYNT RN A novel series of non-carboxylic acid, non-hydantoin inhibitors of aldose reductase with potent oral activity in diabetic rat models: 6-(5-chloro-3... J Med Chem. 2005 Oct 6;48(20):6326-39. DM7WYNT RU https://pubmed.ncbi.nlm.nih.gov/16190759 DM3EDBO DI DM3EDBO DM3EDBO DN 6-(4-Fluorobutyl)-4-methylpyridin-2-amine DM3EDBO MI TTF10I9 DM3EDBO MN Nitric-oxide synthase inducible (NOS2) DM3EDBO MT DTT DM3EDBO MA Inhibitor DM3EDBO RN Design and synthesis of 2-amino-4-methylpyridine analogues as inhibitors for inducible nitric oxide synthase and in vivo evaluation of [18F]6-(2-fl... J Med Chem. 2009 Apr 23;52(8):2443-53. DM3EDBO RU https://pubmed.ncbi.nlm.nih.gov/19323559 DM5JWEY DI DM5JWEY DM5JWEY DN 6-(4-Fluoro-phenylsulfanyl)-9H-purine DM5JWEY MI TTQBR95 DM5JWEY MN Stress-activated protein kinase 2a (p38 alpha) DM5JWEY MT DTT DM5JWEY MA Inhibitor DM5JWEY RN Synthesis and biological testing of purine derivatives as potential ATP-competitive kinase inhibitors. J Med Chem. 2005 Feb 10;48(3):710-22. DM5JWEY RU https://pubmed.ncbi.nlm.nih.gov/15689155 DMKGTRF DI DMKGTRF DMKGTRF DN 6-(4-fluorostyryl)-2-morpholino-4H-chromen-4-one DMKGTRF MI TTK3PY9 DMKGTRF MN DNA-dependent protein kinase catalytic (PRKDC) DMKGTRF MT DTT DMKGTRF MA Inhibitor DMKGTRF RN Discovery of potent chromen-4-one inhibitors of the DNA-dependent protein kinase (DNA-PK) using a small-molecule library approach. J Med Chem. 2005 Dec 1;48(24):7829-46. DMKGTRF RU https://pubmed.ncbi.nlm.nih.gov/16302822 DMYM3EW DI DMYM3EW DMYM3EW DN 6-(4-Hydroxy-2-methoxy-phenyl)-naphthalen-2-ol DMYM3EW MI TTZAYWL DMYM3EW MN Estrogen receptor (ESR) DMYM3EW MT DTT DMYM3EW MA Inhibitor DMYM3EW RN ERbeta ligands. 3. Exploiting two binding orientations of the 2-phenylnaphthalene scaffold to achieve ERbeta selectivity. J Med Chem. 2005 Jun 16;48(12):3953-79. DMYM3EW RU https://pubmed.ncbi.nlm.nih.gov/15943471 DMYM3EW DI DMYM3EW DMYM3EW DN 6-(4-Hydroxy-2-methoxy-phenyl)-naphthalen-2-ol DMYM3EW MI TTOM3J0 DMYM3EW MN Estrogen receptor beta (ESR2) DMYM3EW MT DTT DMYM3EW MA Inhibitor DMYM3EW RN ERbeta ligands. 3. Exploiting two binding orientations of the 2-phenylnaphthalene scaffold to achieve ERbeta selectivity. J Med Chem. 2005 Jun 16;48(12):3953-79. DMYM3EW RU https://pubmed.ncbi.nlm.nih.gov/15943471 DMYEIRH DI DMYEIRH DMYEIRH DN 6-(4-Hydroxy-2-methyl-phenyl)-naphthalen-2-ol DMYEIRH MI TTZAYWL DMYEIRH MN Estrogen receptor (ESR) DMYEIRH MT DTT DMYEIRH MA Inhibitor DMYEIRH RN ERbeta ligands. 3. Exploiting two binding orientations of the 2-phenylnaphthalene scaffold to achieve ERbeta selectivity. J Med Chem. 2005 Jun 16;48(12):3953-79. DMYEIRH RU https://pubmed.ncbi.nlm.nih.gov/15943471 DMYEIRH DI DMYEIRH DMYEIRH DN 6-(4-Hydroxy-2-methyl-phenyl)-naphthalen-2-ol DMYEIRH MI TTOM3J0 DMYEIRH MN Estrogen receptor beta (ESR2) DMYEIRH MT DTT DMYEIRH MA Inhibitor DMYEIRH RN ERbeta ligands. 3. Exploiting two binding orientations of the 2-phenylnaphthalene scaffold to achieve ERbeta selectivity. J Med Chem. 2005 Jun 16;48(12):3953-79. DMYEIRH RU https://pubmed.ncbi.nlm.nih.gov/15943471 DMBG5Y8 DI DMBG5Y8 DMBG5Y8 DN 6-(4-Hydroxy-phenyl)-1-methoxy-naphthalen-2-ol DMBG5Y8 MI TTZAYWL DMBG5Y8 MN Estrogen receptor (ESR) DMBG5Y8 MT DTT DMBG5Y8 MA Inhibitor DMBG5Y8 RN ERbeta ligands. 3. Exploiting two binding orientations of the 2-phenylnaphthalene scaffold to achieve ERbeta selectivity. J Med Chem. 2005 Jun 16;48(12):3953-79. DMBG5Y8 RU https://pubmed.ncbi.nlm.nih.gov/15943471 DMBG5Y8 DI DMBG5Y8 DMBG5Y8 DN 6-(4-Hydroxy-phenyl)-1-methoxy-naphthalen-2-ol DMBG5Y8 MI TTOM3J0 DMBG5Y8 MN Estrogen receptor beta (ESR2) DMBG5Y8 MT DTT DMBG5Y8 MA Inhibitor DMBG5Y8 RN ERbeta ligands. 3. Exploiting two binding orientations of the 2-phenylnaphthalene scaffold to achieve ERbeta selectivity. J Med Chem. 2005 Jun 16;48(12):3953-79. DMBG5Y8 RU https://pubmed.ncbi.nlm.nih.gov/15943471 DMGLT0N DI DMGLT0N DMGLT0N DN 6-(4-Hydroxy-phenyl)-1-methyl-naphthalen-2-ol DMGLT0N MI TTZAYWL DMGLT0N MN Estrogen receptor (ESR) DMGLT0N MT DTT DMGLT0N MA Inhibitor DMGLT0N RN ERbeta ligands. 3. Exploiting two binding orientations of the 2-phenylnaphthalene scaffold to achieve ERbeta selectivity. J Med Chem. 2005 Jun 16;48(12):3953-79. DMGLT0N RU https://pubmed.ncbi.nlm.nih.gov/15943471 DMGLT0N DI DMGLT0N DMGLT0N DN 6-(4-Hydroxy-phenyl)-1-methyl-naphthalen-2-ol DMGLT0N MI TTOM3J0 DMGLT0N MN Estrogen receptor beta (ESR2) DMGLT0N MT DTT DMGLT0N MA Inhibitor DMGLT0N RN ERbeta ligands. 3. Exploiting two binding orientations of the 2-phenylnaphthalene scaffold to achieve ERbeta selectivity. J Med Chem. 2005 Jun 16;48(12):3953-79. DMGLT0N RU https://pubmed.ncbi.nlm.nih.gov/15943471 DMGC84U DI DMGC84U DMGC84U DN 6-(4-Hydroxy-phenyl)-1-nitro-naphthalen-2-ol DMGC84U MI TTZAYWL DMGC84U MN Estrogen receptor (ESR) DMGC84U MT DTT DMGC84U MA Inhibitor DMGC84U RN ERbeta ligands. 3. Exploiting two binding orientations of the 2-phenylnaphthalene scaffold to achieve ERbeta selectivity. J Med Chem. 2005 Jun 16;48(12):3953-79. DMGC84U RU https://pubmed.ncbi.nlm.nih.gov/15943471 DMGC84U DI DMGC84U DMGC84U DN 6-(4-Hydroxy-phenyl)-1-nitro-naphthalen-2-ol DMGC84U MI TTOM3J0 DMGC84U MN Estrogen receptor beta (ESR2) DMGC84U MT DTT DMGC84U MA Inhibitor DMGC84U RN ERbeta ligands. 3. Exploiting two binding orientations of the 2-phenylnaphthalene scaffold to achieve ERbeta selectivity. J Med Chem. 2005 Jun 16;48(12):3953-79. DMGC84U RU https://pubmed.ncbi.nlm.nih.gov/15943471 DMI6UVN DI DMI6UVN DMI6UVN DN 6-(4-Hydroxy-phenyl)-1-phenyl-naphthalen-2-ol DMI6UVN MI TTZAYWL DMI6UVN MN Estrogen receptor (ESR) DMI6UVN MT DTT DMI6UVN MA Inhibitor DMI6UVN RN ERbeta ligands. 3. Exploiting two binding orientations of the 2-phenylnaphthalene scaffold to achieve ERbeta selectivity. J Med Chem. 2005 Jun 16;48(12):3953-79. DMI6UVN RU https://pubmed.ncbi.nlm.nih.gov/15943471 DMI6UVN DI DMI6UVN DMI6UVN DN 6-(4-Hydroxy-phenyl)-1-phenyl-naphthalen-2-ol DMI6UVN MI TTOM3J0 DMI6UVN MN Estrogen receptor beta (ESR2) DMI6UVN MT DTT DMI6UVN MA Inhibitor DMI6UVN RN ERbeta ligands. 3. Exploiting two binding orientations of the 2-phenylnaphthalene scaffold to achieve ERbeta selectivity. J Med Chem. 2005 Jun 16;48(12):3953-79. DMI6UVN RU https://pubmed.ncbi.nlm.nih.gov/15943471 DMTYWCS DI DMTYWCS DMTYWCS DN 6-(4-hydroxyphenyl)-2-morpholino-4H-chromen-4-one DMTYWCS MI TTK3PY9 DMTYWCS MN DNA-dependent protein kinase catalytic (PRKDC) DMTYWCS MT DTT DMTYWCS MA Inhibitor DMTYWCS RN Discovery of potent chromen-4-one inhibitors of the DNA-dependent protein kinase (DNA-PK) using a small-molecule library approach. J Med Chem. 2005 Dec 1;48(24):7829-46. DMTYWCS RU https://pubmed.ncbi.nlm.nih.gov/16302822 DM2V9XI DI DM2V9XI DM2V9XI DN 6-(4-Hydroxy-phenyl)-naphthalen-1-ol DM2V9XI MI TTIWB6L DM2V9XI MN Estradiol 17 beta-dehydrogenase 1 (17-beta-HSD1) DM2V9XI MT DTT DM2V9XI MA Inhibitor DM2V9XI RN Design, synthesis, and biological evaluation of (hydroxyphenyl)naphthalene and -quinoline derivatives: potent and selective nonsteroidal inhibitors... J Med Chem. 2008 Apr 10;51(7):2158-69. DM2V9XI RU https://pubmed.ncbi.nlm.nih.gov/18324762 DM2V9XI DI DM2V9XI DM2V9XI DN 6-(4-Hydroxy-phenyl)-naphthalen-1-ol DM2V9XI MI TTZAYWL DM2V9XI MN Estrogen receptor (ESR) DM2V9XI MT DTT DM2V9XI MA Inhibitor DM2V9XI RN ERbeta ligands. 3. Exploiting two binding orientations of the 2-phenylnaphthalene scaffold to achieve ERbeta selectivity. J Med Chem. 2005 Jun 16;48(12):3953-79. DM2V9XI RU https://pubmed.ncbi.nlm.nih.gov/15943471 DM2V9XI DI DM2V9XI DM2V9XI DN 6-(4-Hydroxy-phenyl)-naphthalen-1-ol DM2V9XI MI TTOM3J0 DM2V9XI MN Estrogen receptor beta (ESR2) DM2V9XI MT DTT DM2V9XI MA Inhibitor DM2V9XI RN ERbeta ligands. 3. Exploiting two binding orientations of the 2-phenylnaphthalene scaffold to achieve ERbeta selectivity. J Med Chem. 2005 Jun 16;48(12):3953-79. DM2V9XI RU https://pubmed.ncbi.nlm.nih.gov/15943471 DM3L2OI DI DM3L2OI DM3L2OI DN 6-(4-Hydroxy-phenyl)-naphthalen-2-ol DM3L2OI MI TTZAYWL DM3L2OI MN Estrogen receptor (ESR) DM3L2OI MT DTT DM3L2OI MA Inhibitor DM3L2OI RN ERbeta ligands. Part 4: Synthesis and structure-activity relationships of a series of 2-phenylquinoline derivatives. Bioorg Med Chem Lett. 2005 Oct 15;15(20):4520-5. DM3L2OI RU https://pubmed.ncbi.nlm.nih.gov/16098741 DM3L2OI DI DM3L2OI DM3L2OI DN 6-(4-Hydroxy-phenyl)-naphthalen-2-ol DM3L2OI MI TTOM3J0 DM3L2OI MN Estrogen receptor beta (ESR2) DM3L2OI MT DTT DM3L2OI MA Inhibitor DM3L2OI RN ERbeta ligands. Part 4: Synthesis and structure-activity relationships of a series of 2-phenylquinoline derivatives. Bioorg Med Chem Lett. 2005 Oct 15;15(20):4520-5. DM3L2OI RU https://pubmed.ncbi.nlm.nih.gov/16098741 DM5LBCH DI DM5LBCH DM5LBCH DN 6-(4-Methoxy-benzenesulfonyl)-2H-pyridazin-3-one DM5LBCH MI TTFBNVI DM5LBCH MN Aldose reductase (AKR1B1) DM5LBCH MT DTT DM5LBCH MA Inhibitor DM5LBCH RN A novel series of non-carboxylic acid, non-hydantoin inhibitors of aldose reductase with potent oral activity in diabetic rat models: 6-(5-chloro-3... J Med Chem. 2005 Oct 6;48(20):6326-39. DM5LBCH RU https://pubmed.ncbi.nlm.nih.gov/16190759 DMUHCO8 DI DMUHCO8 DMUHCO8 DN 6-(4-methoxyphenyl)-4-morpholino-2H-pyran-2-one DMUHCO8 MI TTK3PY9 DMUHCO8 MN DNA-dependent protein kinase catalytic (PRKDC) DMUHCO8 MT DTT DMUHCO8 MA Inhibitor DMUHCO8 RN Pyranone, thiopyranone, and pyridone inhibitors of phosphatidylinositol 3-kinase related kinases. Structure-activity relationships for DNA-dependen... J Med Chem. 2007 Apr 19;50(8):1958-72. DMUHCO8 RU https://pubmed.ncbi.nlm.nih.gov/17371003 DMWITYU DI DMWITYU DMWITYU DN 6-(4-Methylpiperazin-1-yl)-9H-purin-2-amine DMWITYU MI TTXJ178 DMWITYU MN Histamine H4 receptor (H4R) DMWITYU MT DTT DMWITYU MA Inhibitor DMWITYU RN 2,4-Diaminopyrimidines as histamine H4 receptor ligands--Scaffold optimization and pharmacological characterization. Bioorg Med Chem. 2009 Oct 15;17(20):7186-96. DMWITYU RU https://pubmed.ncbi.nlm.nih.gov/19773175 DMA3FQP DI DMA3FQP DMA3FQP DN 6-(4-methylpiperazin-1-yl)-9Hpurine DMA3FQP MI TTXJ178 DMA3FQP MN Histamine H4 receptor (H4R) DMA3FQP MT DTT DMA3FQP MA Inhibitor DMA3FQP RN 2,4-Diaminopyrimidines as histamine H4 receptor ligands--Scaffold optimization and pharmacological characterization. Bioorg Med Chem. 2009 Oct 15;17(20):7186-96. DMA3FQP RU https://pubmed.ncbi.nlm.nih.gov/19773175 DM1HAWR DI DM1HAWR DM1HAWR DN 6-(4-Methyl-piperazin-1-yl)-phenanthridine DM1HAWR MI TTPC4TU DM1HAWR MN 5-HT 3A receptor (HTR3A) DM1HAWR MT DTT DM1HAWR MA Inhibitor DM1HAWR RN Novel potent and selective central 5-HT3 receptor ligands provided with different intrinsic efficacy. 2. Molecular basis of the intrinsic efficacy ... J Med Chem. 1999 May 6;42(9):1556-75. DM1HAWR RU https://pubmed.ncbi.nlm.nih.gov/10229626 DM1HAWR DI DM1HAWR DM1HAWR DN 6-(4-Methyl-piperazin-1-yl)-phenanthridine DM1HAWR MI TTR6K75 DM1HAWR MN 5-HT 3B receptor (HTR3B) DM1HAWR MT DTT DM1HAWR MA Inhibitor DM1HAWR RN Novel potent and selective central 5-HT3 receptor ligands provided with different intrinsic efficacy. 2. Molecular basis of the intrinsic efficacy ... J Med Chem. 1999 May 6;42(9):1556-75. DM1HAWR RU https://pubmed.ncbi.nlm.nih.gov/10229626 DMYAS2V DI DMYAS2V DMYAS2V DN 6-(4-Methylpiperazin-1-yl)pyrimidine-2,4-diamine DMYAS2V MI TTXJ178 DMYAS2V MN Histamine H4 receptor (H4R) DMYAS2V MT DTT DMYAS2V MA Inhibitor DMYAS2V RN 2,4-Diaminopyrimidines as histamine H4 receptor ligands--Scaffold optimization and pharmacological characterization. Bioorg Med Chem. 2009 Oct 15;17(20):7186-96. DMYAS2V RU https://pubmed.ncbi.nlm.nih.gov/19773175 DMTV753 DI DMTV753 DMTV753 DN 6-(4-Methylpyridin-3-yl)-2-naphthonitrile DMTV753 MI TTIQUX7 DMTV753 MN Steroid 11-beta-hydroxylase (CYP11B1) DMTV753 MT DTT DMTV753 MA Inhibitor DMTV753 RN Overcoming undesirable CYP1A2 inhibition of pyridylnaphthalene-type aldosterone synthase inhibitors: influence of heteroaryl derivatization on pote... J Med Chem. 2008 Aug 28;51(16):5064-74. DMTV753 RU https://pubmed.ncbi.nlm.nih.gov/18672861 DMPL5XV DI DMPL5XV DMPL5XV DN 6-(4-Nitro-benzylsulfanyl)-9-phenethyl-9H-purine DMPL5XV MI TTLXAKE DMPL5XV MN Solute carrier family 29 member 1 (SLC29A1) DMPL5XV MT DTT DMPL5XV MA Inhibitor DMPL5XV RN Inhibition of nucleoside transport by new analogues of 4-nitrobenzylthioinosine: replacement of the ribose moiety by substituted benzyl groups. J Med Chem. 2004 Oct 21;47(22):5441-50. DMPL5XV RU https://pubmed.ncbi.nlm.nih.gov/15481982 DMVMDJ3 DI DMVMDJ3 DMVMDJ3 DN 6-(9H-carbazol-9-yl)-N-hydroxyhexanamide DMVMDJ3 MI TT6R7JZ DMVMDJ3 MN Histone deacetylase 1 (HDAC1) DMVMDJ3 MT DTT DMVMDJ3 MA Inhibitor DMVMDJ3 RN Inhibitors selective for HDAC6 in enzymes and cells. Bioorg Med Chem Lett. 2010 Dec 1;20(23):7067-70. DMVMDJ3 RU https://pubmed.ncbi.nlm.nih.gov/20947351 DMVMDJ3 DI DMVMDJ3 DMVMDJ3 DN 6-(9H-carbazol-9-yl)-N-hydroxyhexanamide DMVMDJ3 MI TT5ZKDI DMVMDJ3 MN Histone deacetylase 6 (HDAC6) DMVMDJ3 MT DTT DMVMDJ3 MA Inhibitor DMVMDJ3 RN Inhibitors selective for HDAC6 in enzymes and cells. Bioorg Med Chem Lett. 2010 Dec 1;20(23):7067-70. DMVMDJ3 RU https://pubmed.ncbi.nlm.nih.gov/20947351 DMYMJHF DI DMYMJHF DMYMJHF DN 6-(Allyl-methyl-amino)-4,4-diphenyl-heptan-3-ol DMYMJHF MI TT27RFC DMYMJHF MN Opioid receptor delta (OPRD1) DMYMJHF MT DTT DMYMJHF MA Inhibitor DMYMJHF RN Synthesis of analogues of acetylmethadol and methadol as potential narcotic antagonists. J Med Chem. 1981 Jul;24(7):903-6. DMYMJHF RU https://pubmed.ncbi.nlm.nih.gov/6268789 DMYMJHF DI DMYMJHF DMYMJHF DN 6-(Allyl-methyl-amino)-4,4-diphenyl-heptan-3-ol DMYMJHF MI TTQW87Y DMYMJHF MN Opioid receptor kappa (OPRK1) DMYMJHF MT DTT DMYMJHF MA Inhibitor DMYMJHF RN Synthesis of analogues of acetylmethadol and methadol as potential narcotic antagonists. J Med Chem. 1981 Jul;24(7):903-6. DMYMJHF RU https://pubmed.ncbi.nlm.nih.gov/6268789 DMYMJHF DI DMYMJHF DMYMJHF DN 6-(Allyl-methyl-amino)-4,4-diphenyl-heptan-3-ol DMYMJHF MI TTKWM86 DMYMJHF MN Opioid receptor mu (MOP) DMYMJHF MT DTT DMYMJHF MA Inhibitor DMYMJHF RN Synthesis of analogues of acetylmethadol and methadol as potential narcotic antagonists. J Med Chem. 1981 Jul;24(7):903-6. DMYMJHF RU https://pubmed.ncbi.nlm.nih.gov/6268789 DMJU9TG DI DMJU9TG DMJU9TG DN 6-(aminomethyl)-2H-chromen-2-one DMJU9TG MI TTUNARX DMJU9TG MN Carbonic anhydrase (CA) DMJU9TG MT DTT DMJU9TG MA Inhibitor DMJU9TG RN Deciphering the mechanism of carbonic anhydrase inhibition with coumarins and thiocoumarins. J Med Chem. 2010 Jan 14;53(1):335-44. DMJU9TG RU https://pubmed.ncbi.nlm.nih.gov/19911821 DMJU9TG DI DMJU9TG DMJU9TG DN 6-(aminomethyl)-2H-chromen-2-one DMJU9TG MI TTHQPL7 DMJU9TG MN Carbonic anhydrase I (CA-I) DMJU9TG MT DTT DMJU9TG MA Inhibitor DMJU9TG RN Deciphering the mechanism of carbonic anhydrase inhibition with coumarins and thiocoumarins. J Med Chem. 2010 Jan 14;53(1):335-44. DMJU9TG RU https://pubmed.ncbi.nlm.nih.gov/19911821 DMJU9TG DI DMJU9TG DMJU9TG DN 6-(aminomethyl)-2H-chromen-2-one DMJU9TG MI TTANPDJ DMJU9TG MN Carbonic anhydrase II (CA-II) DMJU9TG MT DTT DMJU9TG MA Inhibitor DMJU9TG RN Deciphering the mechanism of carbonic anhydrase inhibition with coumarins and thiocoumarins. J Med Chem. 2010 Jan 14;53(1):335-44. DMJU9TG RU https://pubmed.ncbi.nlm.nih.gov/19911821 DMJU9TG DI DMJU9TG DMJU9TG DN 6-(aminomethyl)-2H-chromen-2-one DMJU9TG MI TTZHA0O DMJU9TG MN Carbonic anhydrase IV (CA-IV) DMJU9TG MT DTT DMJU9TG MA Inhibitor DMJU9TG RN Deciphering the mechanism of carbonic anhydrase inhibition with coumarins and thiocoumarins. J Med Chem. 2010 Jan 14;53(1):335-44. DMJU9TG RU https://pubmed.ncbi.nlm.nih.gov/19911821 DMJU9TG DI DMJU9TG DMJU9TG DN 6-(aminomethyl)-2H-chromen-2-one DMJU9TG MI TT2LVK8 DMJU9TG MN Carbonic anhydrase IX (CA-IX) DMJU9TG MT DTT DMJU9TG MA Inhibitor DMJU9TG RN Deciphering the mechanism of carbonic anhydrase inhibition with coumarins and thiocoumarins. J Med Chem. 2010 Jan 14;53(1):335-44. DMJU9TG RU https://pubmed.ncbi.nlm.nih.gov/19911821 DMJU9TG DI DMJU9TG DMJU9TG DN 6-(aminomethyl)-2H-chromen-2-one DMJU9TG MI TTCFSPE DMJU9TG MN Carbonic anhydrase VI (CA-VI) DMJU9TG MT DTT DMJU9TG MA Inhibitor DMJU9TG RN Deciphering the mechanism of carbonic anhydrase inhibition with coumarins and thiocoumarins. J Med Chem. 2010 Jan 14;53(1):335-44. DMJU9TG RU https://pubmed.ncbi.nlm.nih.gov/19911821 DMJU9TG DI DMJU9TG DMJU9TG DN 6-(aminomethyl)-2H-chromen-2-one DMJU9TG MI TTSYM0R DMJU9TG MN Carbonic anhydrase XII (CA-XII) DMJU9TG MT DTT DMJU9TG MA Inhibitor DMJU9TG RN Deciphering the mechanism of carbonic anhydrase inhibition with coumarins and thiocoumarins. J Med Chem. 2010 Jan 14;53(1):335-44. DMJU9TG RU https://pubmed.ncbi.nlm.nih.gov/19911821 DMJU9TG DI DMJU9TG DMJU9TG DN 6-(aminomethyl)-2H-chromen-2-one DMJU9TG MI TTEYTKG DMJU9TG MN Carbonic anhydrase XIV (CA-XIV) DMJU9TG MT DTT DMJU9TG MA Inhibitor DMJU9TG RN Deciphering the mechanism of carbonic anhydrase inhibition with coumarins and thiocoumarins. J Med Chem. 2010 Jan 14;53(1):335-44. DMJU9TG RU https://pubmed.ncbi.nlm.nih.gov/19911821 DM2GFI3 DI DM2GFI3 DM2GFI3 DN 6-(Benzofuran-2-sulfonyl)-2H-pyridazin-3-one DM2GFI3 MI TTFBNVI DM2GFI3 MN Aldose reductase (AKR1B1) DM2GFI3 MT DTT DM2GFI3 MA Inhibitor DM2GFI3 RN A novel series of non-carboxylic acid, non-hydantoin inhibitors of aldose reductase with potent oral activity in diabetic rat models: 6-(5-chloro-3... J Med Chem. 2005 Oct 6;48(20):6326-39. DM2GFI3 RU https://pubmed.ncbi.nlm.nih.gov/16190759 DMXLDHR DI DMXLDHR DMXLDHR DN 6-(Benzothiazole-2-sulfonyl)-2H-pyridazin-3-one DMXLDHR MI TTFBNVI DMXLDHR MN Aldose reductase (AKR1B1) DMXLDHR MT DTT DMXLDHR MA Inhibitor DMXLDHR RN A novel series of non-carboxylic acid, non-hydantoin inhibitors of aldose reductase with potent oral activity in diabetic rat models: 6-(5-chloro-3... J Med Chem. 2005 Oct 6;48(20):6326-39. DMXLDHR RU https://pubmed.ncbi.nlm.nih.gov/16190759 DM7BIJH DI DM7BIJH DM7BIJH DN 6-(benzylamino)-9-butyl-9H-purine-2-carbonitrile DM7BIJH MI TT36ETB DM7BIJH MN Cathepsin L (CTSL) DM7BIJH MT DTT DM7BIJH MA Inhibitor DM7BIJH RN Development of potent purine-derived nitrile inhibitors of the trypanosomal protease TbcatB. J Med Chem. 2008 Feb 14;51(3):545-52. DM7BIJH RU https://pubmed.ncbi.nlm.nih.gov/18173229 DM4KMDB DI DM4KMDB DM4KMDB DN 6-(Biphenyl-2-sulfonyl)-2H-pyridazin-3-one DM4KMDB MI TTFBNVI DM4KMDB MN Aldose reductase (AKR1B1) DM4KMDB MT DTT DM4KMDB MA Inhibitor DM4KMDB RN A novel series of non-carboxylic acid, non-hydantoin inhibitors of aldose reductase with potent oral activity in diabetic rat models: 6-(5-chloro-3... J Med Chem. 2005 Oct 6;48(20):6326-39. DM4KMDB RU https://pubmed.ncbi.nlm.nih.gov/16190759 DMAYWIN DI DMAYWIN DMAYWIN DN 6-(Cyclohex-3-enylmethoxy)-9H-purin-2-ylamine DMAYWIN MI TTAMQ62 DMAYWIN MN Cyclin A2 (CCNA2) DMAYWIN MT DTT DMAYWIN MA Inhibitor DMAYWIN RN Probing the ATP ribose-binding domain of cyclin-dependent kinases 1 and 2 with O(6)-substituted guanine derivatives. J Med Chem. 2002 Aug 1;45(16):3381-93. DMAYWIN RU https://pubmed.ncbi.nlm.nih.gov/12139449 DMAYWIN DI DMAYWIN DMAYWIN DN 6-(Cyclohex-3-enylmethoxy)-9H-purin-2-ylamine DMAYWIN MI TT7HF4W DMAYWIN MN Cyclin-dependent kinase 2 (CDK2) DMAYWIN MT DTT DMAYWIN MA Inhibitor DMAYWIN RN Probing the ATP ribose-binding domain of cyclin-dependent kinases 1 and 2 with O(6)-substituted guanine derivatives. J Med Chem. 2002 Aug 1;45(16):3381-93. DMAYWIN RU https://pubmed.ncbi.nlm.nih.gov/12139449 DMQPTL5 DI DMQPTL5 DMQPTL5 DN 6-(Dihydroxy-Isobutyl)-Thymine DMQPTL5 MI TTP3QRF DMQPTL5 MN Thymidine kinase 1 (TK1) DMQPTL5 MT DTT DMQPTL5 MA Inhibitor DMQPTL5 RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMQPTL5 RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMOYCBH DI DMOYCBH DMOYCBH DN 6-(furan-2-yl)-9H-purin-2-amine DMOYCBH MI TTK25J1 DMOYCBH MN Adenosine A1 receptor (ADORA1) DMOYCBH MT DTT DMOYCBH MA Inhibitor DMOYCBH RN Antagonists of the human A(2A) adenosine receptor. 4. Design, synthesis, and preclinical evaluation of 7-aryltriazolo[4,5-d]pyrimidines. J Med Chem. 2009 Jan 8;52(1):33-47. DMOYCBH RU https://pubmed.ncbi.nlm.nih.gov/19072055 DMOYCBH DI DMOYCBH DMOYCBH DN 6-(furan-2-yl)-9H-purin-2-amine DMOYCBH MI TTM2AOE DMOYCBH MN Adenosine A2a receptor (ADORA2A) DMOYCBH MT DTT DMOYCBH MA Inhibitor DMOYCBH RN Antagonists of the human A(2A) adenosine receptor. 4. Design, synthesis, and preclinical evaluation of 7-aryltriazolo[4,5-d]pyrimidines. J Med Chem. 2009 Jan 8;52(1):33-47. DMOYCBH RU https://pubmed.ncbi.nlm.nih.gov/19072055 DM5TOX2 DI DM5TOX2 DM5TOX2 DN 6-(hydroxymethyl)-2H-chromen-2-one DM5TOX2 MI TTUNARX DM5TOX2 MN Carbonic anhydrase (CA) DM5TOX2 MT DTT DM5TOX2 MA Inhibitor DM5TOX2 RN Deciphering the mechanism of carbonic anhydrase inhibition with coumarins and thiocoumarins. J Med Chem. 2010 Jan 14;53(1):335-44. DM5TOX2 RU https://pubmed.ncbi.nlm.nih.gov/19911821 DM5TOX2 DI DM5TOX2 DM5TOX2 DN 6-(hydroxymethyl)-2H-chromen-2-one DM5TOX2 MI TTANPDJ DM5TOX2 MN Carbonic anhydrase II (CA-II) DM5TOX2 MT DTT DM5TOX2 MA Inhibitor DM5TOX2 RN Deciphering the mechanism of carbonic anhydrase inhibition with coumarins and thiocoumarins. J Med Chem. 2010 Jan 14;53(1):335-44. DM5TOX2 RU https://pubmed.ncbi.nlm.nih.gov/19911821 DM5TOX2 DI DM5TOX2 DM5TOX2 DN 6-(hydroxymethyl)-2H-chromen-2-one DM5TOX2 MI TTZHA0O DM5TOX2 MN Carbonic anhydrase IV (CA-IV) DM5TOX2 MT DTT DM5TOX2 MA Inhibitor DM5TOX2 RN Deciphering the mechanism of carbonic anhydrase inhibition with coumarins and thiocoumarins. J Med Chem. 2010 Jan 14;53(1):335-44. DM5TOX2 RU https://pubmed.ncbi.nlm.nih.gov/19911821 DM5TOX2 DI DM5TOX2 DM5TOX2 DN 6-(hydroxymethyl)-2H-chromen-2-one DM5TOX2 MI TT2LVK8 DM5TOX2 MN Carbonic anhydrase IX (CA-IX) DM5TOX2 MT DTT DM5TOX2 MA Inhibitor DM5TOX2 RN Deciphering the mechanism of carbonic anhydrase inhibition with coumarins and thiocoumarins. J Med Chem. 2010 Jan 14;53(1):335-44. DM5TOX2 RU https://pubmed.ncbi.nlm.nih.gov/19911821 DM5TOX2 DI DM5TOX2 DM5TOX2 DN 6-(hydroxymethyl)-2H-chromen-2-one DM5TOX2 MI TTCFSPE DM5TOX2 MN Carbonic anhydrase VI (CA-VI) DM5TOX2 MT DTT DM5TOX2 MA Inhibitor DM5TOX2 RN Deciphering the mechanism of carbonic anhydrase inhibition with coumarins and thiocoumarins. J Med Chem. 2010 Jan 14;53(1):335-44. DM5TOX2 RU https://pubmed.ncbi.nlm.nih.gov/19911821 DM5TOX2 DI DM5TOX2 DM5TOX2 DN 6-(hydroxymethyl)-2H-chromen-2-one DM5TOX2 MI TTSYM0R DM5TOX2 MN Carbonic anhydrase XII (CA-XII) DM5TOX2 MT DTT DM5TOX2 MA Inhibitor DM5TOX2 RN Deciphering the mechanism of carbonic anhydrase inhibition with coumarins and thiocoumarins. J Med Chem. 2010 Jan 14;53(1):335-44. DM5TOX2 RU https://pubmed.ncbi.nlm.nih.gov/19911821 DM5TOX2 DI DM5TOX2 DM5TOX2 DN 6-(hydroxymethyl)-2H-chromen-2-one DM5TOX2 MI TTEYTKG DM5TOX2 MN Carbonic anhydrase XIV (CA-XIV) DM5TOX2 MT DTT DM5TOX2 MA Inhibitor DM5TOX2 RN Deciphering the mechanism of carbonic anhydrase inhibition with coumarins and thiocoumarins. J Med Chem. 2010 Jan 14;53(1):335-44. DM5TOX2 RU https://pubmed.ncbi.nlm.nih.gov/19911821 DMSH107 DI DMSH107 DMSH107 DN 6-(Indan-5-ylamino)-1H-pyrimidine-2,4-dione DMSH107 MI TT2GPK3 DMSH107 MN DNA topoisomerase (TOP) DMSH107 MT DTT DMSH107 MA Inhibitor DMSH107 RN Inhibitors of Bacillus subtilis DNA polymerase III. 6-Anilinouracils and 6-(alkylamino)uracils. J Med Chem. 1980 Jan;23(1):34-8. DMSH107 RU https://pubmed.ncbi.nlm.nih.gov/6767030 DMM2TFX DI DMM2TFX DMM2TFX DN 6-(Naphthalen-2-ylamino)-1H-pyrimidine-2,4-dione DMM2TFX MI TT2GPK3 DMM2TFX MN DNA topoisomerase (TOP) DMM2TFX MT DTT DMM2TFX MA Inhibitor DMM2TFX RN Inhibitors of Bacillus subtilis DNA polymerase III. 6-Anilinouracils and 6-(alkylamino)uracils. J Med Chem. 1980 Jan;23(1):34-8. DMM2TFX RU https://pubmed.ncbi.nlm.nih.gov/6767030 DMXSCQE DI DMXSCQE DMXSCQE DN 6-(Naphthalene-1-sulfonyl)-2H-pyridazin-3-one DMXSCQE MI TTFBNVI DMXSCQE MN Aldose reductase (AKR1B1) DMXSCQE MT DTT DMXSCQE MA Inhibitor DMXSCQE RN A novel series of non-carboxylic acid, non-hydantoin inhibitors of aldose reductase with potent oral activity in diabetic rat models: 6-(5-chloro-3... J Med Chem. 2005 Oct 6;48(20):6326-39. DMXSCQE RU https://pubmed.ncbi.nlm.nih.gov/16190759 DMCIA63 DI DMCIA63 DMCIA63 DN 6-(Naphthalene-2-sulfonyl)-2H-pyridazin-3-one DMCIA63 MI TTFBNVI DMCIA63 MN Aldose reductase (AKR1B1) DMCIA63 MT DTT DMCIA63 MA Inhibitor DMCIA63 RN A novel series of non-carboxylic acid, non-hydantoin inhibitors of aldose reductase with potent oral activity in diabetic rat models: 6-(5-chloro-3... J Med Chem. 2005 Oct 6;48(20):6326-39. DMCIA63 RU https://pubmed.ncbi.nlm.nih.gov/16190759 DMHM0RW DI DMHM0RW DMHM0RW DN 6-(N-Phenylcarbamyl)-2-Naphthalenecarboxamidine DMHM0RW MI TTGY7WI DMHM0RW MN Urokinase-type plasminogen activator (PLAU) DMHM0RW MT DTT DMHM0RW MA Inhibitor DMHM0RW RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMHM0RW RU https://pubmed.ncbi.nlm.nih.gov/17139284 DM1LY0S DI DM1LY0S DM1LY0S DN 6-(Oxalyl-Amino)-1h-Indole-5-Carboxylic Acid DM1LY0S MI TTELIN2 DM1LY0S MN PTPN1 messenger RNA (PTPN1 mRNA) DM1LY0S MT DTT DM1LY0S MA Inhibitor DM1LY0S RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DM1LY0S RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMM9G0J DI DMM9G0J DMM9G0J DN 6-(piperazin-1-yl)-3-tosyl-1H-indazole DMM9G0J MI TTJS8PY DMM9G0J MN 5-HT 6 receptor (HTR6) DMM9G0J MT DTT DMM9G0J MA Inhibitor DMM9G0J RN 5-Piperazinyl-3-sulfonylindazoles as potent and selective 5-hydroxytryptamine-6 antagonists. J Med Chem. 2010 Nov 11;53(21):7639-46. DMM9G0J RU https://pubmed.ncbi.nlm.nih.gov/20932009 DMUNWJR DI DMUNWJR DMUNWJR DN 6-(piperazin-1-yl)-9-propyl-9H-purine DMUNWJR MI TTWJBZ5 DMUNWJR MN 5-HT 2C receptor (HTR2C) DMUNWJR MT DTT DMUNWJR MA Inhibitor DMUNWJR RN Design and synthesis of orally-active and selective azaindane 5HT2c agonist for the treatment of obesity. Bioorg Med Chem Lett. 2010 Jan 1;20(1):266-71. DMUNWJR RU https://pubmed.ncbi.nlm.nih.gov/19914063 DMBQKGY DI DMBQKGY DMBQKGY DN 6-(piperidin-4-ylmethoxy)-2-naphthonitrile DMBQKGY MI TTVBI8W DMBQKGY MN Dopamine transporter (DAT) DMBQKGY MT DTT DMBQKGY MA Inhibitor DMBQKGY RN Design and optimization of selective serotonin re-uptake inhibitors with high synthetic accessibility. Part 1. Bioorg Med Chem Lett. 2009 Apr 15;19(8):2329-32. DMBQKGY RU https://pubmed.ncbi.nlm.nih.gov/19282174 DMBQKGY DI DMBQKGY DMBQKGY DN 6-(piperidin-4-ylmethoxy)-2-naphthonitrile DMBQKGY MI TTAWNKZ DMBQKGY MN Norepinephrine transporter (NET) DMBQKGY MT DTT DMBQKGY MA Inhibitor DMBQKGY RN Design and optimization of selective serotonin re-uptake inhibitors with high synthetic accessibility. Part 1. Bioorg Med Chem Lett. 2009 Apr 15;19(8):2329-32. DMBQKGY RU https://pubmed.ncbi.nlm.nih.gov/19282174 DMBQKGY DI DMBQKGY DMBQKGY DN 6-(piperidin-4-ylmethoxy)-2-naphthonitrile DMBQKGY MI TT3ROYC DMBQKGY MN Serotonin transporter (SERT) DMBQKGY MT DTT DMBQKGY MA Inhibitor DMBQKGY RN Design and optimization of selective serotonin re-uptake inhibitors with high synthetic accessibility. Part 1. Bioorg Med Chem Lett. 2009 Apr 15;19(8):2329-32. DMBQKGY RU https://pubmed.ncbi.nlm.nih.gov/19282174 DMC3SJI DI DMC3SJI DMC3SJI DN 6-(pyridin-3-yl)-2-naphthonitrile DMC3SJI MI TTIQUX7 DMC3SJI MN Steroid 11-beta-hydroxylase (CYP11B1) DMC3SJI MT DTT DMC3SJI MA Inhibitor DMC3SJI RN Overcoming undesirable CYP1A2 inhibition of pyridylnaphthalene-type aldosterone synthase inhibitors: influence of heteroaryl derivatization on pote... J Med Chem. 2008 Aug 28;51(16):5064-74. DMC3SJI RU https://pubmed.ncbi.nlm.nih.gov/18672861 DMC3SJI DI DMC3SJI DMC3SJI DN 6-(pyridin-3-yl)-2-naphthonitrile DMC3SJI MI TTRA5BZ DMC3SJI MN Steroid 17-alpha-monooxygenase (S17AH) DMC3SJI MT DTT DMC3SJI MA Inhibitor DMC3SJI RN In vivo active aldosterone synthase inhibitors with improved selectivity: lead optimization providing a series of pyridine substituted 3,4-dihydro-... J Med Chem. 2008 Dec 25;51(24):8077-87. DMC3SJI RU https://pubmed.ncbi.nlm.nih.gov/19049427 DMV3MF4 DI DMV3MF4 DMV3MF4 DN 6-(Toluene-4-sulfonyl)-2H-pyridazin-3-one DMV3MF4 MI TTFBNVI DMV3MF4 MN Aldose reductase (AKR1B1) DMV3MF4 MT DTT DMV3MF4 MA Inhibitor DMV3MF4 RN A novel series of non-carboxylic acid, non-hydantoin inhibitors of aldose reductase with potent oral activity in diabetic rat models: 6-(5-chloro-3... J Med Chem. 2005 Oct 6;48(20):6326-39. DMV3MF4 RU https://pubmed.ncbi.nlm.nih.gov/16190759 DMSB8WQ DI DMSB8WQ DMSB8WQ DN 6,11-dihydro-5H-benzo[a]carbazole DMSB8WQ MI TT3WG5C DMSB8WQ MN Monoamine oxidase type A (MAO-A) DMSB8WQ MT DTT DMSB8WQ MA Inhibitor DMSB8WQ RN Synthesis and monoamine oxidase inhibitory activity of new pyridazine-, pyrimidine- and 1,2,4-triazine-containing tricyclic derivatives. J Med Chem. 2007 Nov 1;50(22):5364-71. DMSB8WQ RU https://pubmed.ncbi.nlm.nih.gov/17910428 DM0RB53 DI DM0RB53 DM0RB53 DN 6,11-dihydrothiochromeno[4,3-b]indol-8-ol DM0RB53 MI TTS64P2 DM0RB53 MN Androgen receptor (AR) DM0RB53 MT DTT DM0RB53 MA Inhibitor DM0RB53 RN Discovery of indole-containing tetracycles as a new scaffold for androgen receptor ligands. Bioorg Med Chem Lett. 2006 Jun 15;16(12):3233-7. DM0RB53 RU https://pubmed.ncbi.nlm.nih.gov/16603353 DMMZTE3 DI DMMZTE3 DMMZTE3 DN 6,6-dimethyl-1-phenyl-3-aza-bicyclo[3.1.0]hexane DMMZTE3 MI TT3ROYC DMMZTE3 MN Serotonin transporter (SERT) DMMZTE3 MT DTT DMMZTE3 MA Inhibitor DMMZTE3 RN Studies on the structure-activity relationship of bicifadine analogs as monoamine transporter inhibitors. Bioorg Med Chem Lett. 2008 Jul 1;18(13):3682-6. DMMZTE3 RU https://pubmed.ncbi.nlm.nih.gov/18539031 DMOIFAP DI DMOIFAP DMOIFAP DN 6,6-Dimethyl-2-oxa-spiro[4.4]nonan-1-one DMOIFAP MI TT1MPAY DMOIFAP MN GABA(A) receptor alpha-1 (GABRA1) DMOIFAP MT DTT DMOIFAP MA Inhibitor DMOIFAP RN Alpha-spirocyclopentyl- and alpha-spirocyclopropyl-gamma-butyrolactones: conformationally constrained derivatives of anticonvulsant and convulsant ... J Med Chem. 1994 Jan 21;37(2):275-86. DMOIFAP RU https://pubmed.ncbi.nlm.nih.gov/8295215 DMOIFAP DI DMOIFAP DMOIFAP DN 6,6-Dimethyl-2-oxa-spiro[4.4]nonan-1-one DMOIFAP MI TTZA1NY DMOIFAP MN GABA(A) receptor beta-2 (GABRB2) DMOIFAP MT DTT DMOIFAP MA Inhibitor DMOIFAP RN Alpha-spirocyclopentyl- and alpha-spirocyclopropyl-gamma-butyrolactones: conformationally constrained derivatives of anticonvulsant and convulsant ... J Med Chem. 1994 Jan 21;37(2):275-86. DMOIFAP RU https://pubmed.ncbi.nlm.nih.gov/8295215 DMOIFAP DI DMOIFAP DMOIFAP DN 6,6-Dimethyl-2-oxa-spiro[4.4]nonan-1-one DMOIFAP MI TT06RH5 DMOIFAP MN GABA(A) receptor gamma-2 (GABRG2) DMOIFAP MT DTT DMOIFAP MA Inhibitor DMOIFAP RN Alpha-spirocyclopentyl- and alpha-spirocyclopropyl-gamma-butyrolactones: conformationally constrained derivatives of anticonvulsant and convulsant ... J Med Chem. 1994 Jan 21;37(2):275-86. DMOIFAP RU https://pubmed.ncbi.nlm.nih.gov/8295215 DMOIFAP DI DMOIFAP DMOIFAP DN 6,6-Dimethyl-2-oxa-spiro[4.4]nonan-1-one DMOIFAP MI TTNJYV2 DMOIFAP MN Gamma-aminobutyric acid receptor (GAR) DMOIFAP MT DTT DMOIFAP MA Inhibitor DMOIFAP RN Alpha-spirocyclopentyl- and alpha-spirocyclopropyl-gamma-butyrolactones: conformationally constrained derivatives of anticonvulsant and convulsant ... J Med Chem. 1994 Jan 21;37(2):275-86. DMOIFAP RU https://pubmed.ncbi.nlm.nih.gov/8295215 DMNOI7B DI DMNOI7B DMNOI7B DN 6,7,8,9-Tetrahydro-5-thia-8-aza-benzocycloheptene DMNOI7B MI TTWG9A4 DMNOI7B MN Adrenergic receptor alpha-2A (ADRA2A) DMNOI7B MT DTT DMNOI7B MA Inhibitor DMNOI7B RN Effect of ring size or an additional heteroatom on the potency and selectivity of bicyclic benzylamine-type inhibitors of phenylethanolamine N-meth... J Med Chem. 1996 Aug 30;39(18):3539-46. DMNOI7B RU https://pubmed.ncbi.nlm.nih.gov/8784452 DMNOI7B DI DMNOI7B DMNOI7B DN 6,7,8,9-Tetrahydro-5-thia-8-aza-benzocycloheptene DMNOI7B MI TTWM4TY DMNOI7B MN Adrenergic receptor alpha-2B (ADRA2B) DMNOI7B MT DTT DMNOI7B MA Inhibitor DMNOI7B RN Effect of ring size or an additional heteroatom on the potency and selectivity of bicyclic benzylamine-type inhibitors of phenylethanolamine N-meth... J Med Chem. 1996 Aug 30;39(18):3539-46. DMNOI7B RU https://pubmed.ncbi.nlm.nih.gov/8784452 DMNOI7B DI DMNOI7B DMNOI7B DN 6,7,8,9-Tetrahydro-5-thia-8-aza-benzocycloheptene DMNOI7B MI TT2NUT5 DMNOI7B MN Adrenergic receptor alpha-2C (ADRA2C) DMNOI7B MT DTT DMNOI7B MA Inhibitor DMNOI7B RN Effect of ring size or an additional heteroatom on the potency and selectivity of bicyclic benzylamine-type inhibitors of phenylethanolamine N-meth... J Med Chem. 1996 Aug 30;39(18):3539-46. DMNOI7B RU https://pubmed.ncbi.nlm.nih.gov/8784452 DMAMD87 DI DMAMD87 DMAMD87 DN 6,7,8-Trimethoxy-1,4-dimethylquinolin-2(1H)-one DMAMD87 MI TTJLP0R DMAMD87 MN Quinone reductase 2 (NQO2) DMAMD87 MT DTT DMAMD87 MA Inhibitor DMAMD87 RN Synthesis of casimiroin and optimization of its quinone reductase 2 and aromatase inhibitory activities. J Med Chem. 2009 Apr 9;52(7):1873-84. DMAMD87 RU https://pubmed.ncbi.nlm.nih.gov/19265439 DMJX9NQ DI DMJX9NQ DMJX9NQ DN 6,7,8-Trimethoxy-4-methylquinolin-2(1H)-one DMJX9NQ MI TTJLP0R DMJX9NQ MN Quinone reductase 2 (NQO2) DMJX9NQ MT DTT DMJX9NQ MA Inhibitor DMJX9NQ RN Synthesis of casimiroin and optimization of its quinone reductase 2 and aromatase inhibitory activities. J Med Chem. 2009 Apr 9;52(7):1873-84. DMJX9NQ RU https://pubmed.ncbi.nlm.nih.gov/19265439 DMDO083 DI DMDO083 DMDO083 DN 6,7-dibromoquinoline-5,8-dione DMDO083 MI TTR0SWN DMDO083 MN M-phase inducer phosphatase 2 (MPIP2) DMDO083 MT DTT DMDO083 MA Inhibitor DMDO083 RN Novel naphthoquinone and quinolinedione inhibitors of CDC25 phosphatase activity with antiproliferative properties. Bioorg Med Chem. 2008 Oct 1;16(19):9040-9. DMDO083 RU https://pubmed.ncbi.nlm.nih.gov/18789703 DMMX1QJ DI DMMX1QJ DMMX1QJ DN 6,7-Dichloro-1,4-dihydro-quinoxaline-2,3-dione DMMX1QJ MI TTLD29N DMMX1QJ MN Glutamate receptor ionotropic NMDA 1 (NMDAR1) DMMX1QJ MT DTT DMMX1QJ MA Inhibitor DMMX1QJ RN 1-Hydroxy-1,4-dihydroquinoxaline-2,3-diones: Novel antagonists at NMDA receptor glycine sites, Bioorg. Med. Chem. Lett. 6(4):439-440 (1996). DMMX1QJ RU http://www.sciencedirect.com/science/article/pii/0960894X96000364 DMZHDFM DI DMZHDFM DMZHDFM DN 6,7-dichloro-1H-indole-2,3-dione DMZHDFM MI TTMF541 DMZHDFM MN Liver carboxylesterase (CES1) DMZHDFM MT DTT DMZHDFM MA Inhibitor DMZHDFM RN Selective inhibition of carboxylesterases by isatins, indole-2,3-diones. J Med Chem. 2007 Apr 19;50(8):1876-85. DMZHDFM RU https://pubmed.ncbi.nlm.nih.gov/17378546 DM592FB DI DM592FB DM592FB DN 6,7-dichloro-2,3,4,5-tetrahydro-1H-3-benzazepine DM592FB MI TTJQOD7 DM592FB MN 5-HT 2A receptor (HTR2A) DM592FB MT DTT DM592FB MA Inhibitor DM592FB RN Synthesis and structure-activity relationships of a series of benzazepine derivatives as 5-HT2C receptor agonists. Bioorg Med Chem. 2008 Mar 15;16(6):3309-20. DM592FB RU https://pubmed.ncbi.nlm.nih.gov/18083579 DM592FB DI DM592FB DM592FB DN 6,7-dichloro-2,3,4,5-tetrahydro-1H-3-benzazepine DM592FB MI TT0K1SC DM592FB MN 5-HT 2B receptor (HTR2B) DM592FB MT DTT DM592FB MA Inhibitor DM592FB RN Synthesis and structure-activity relationships of a series of benzazepine derivatives as 5-HT2C receptor agonists. Bioorg Med Chem. 2008 Mar 15;16(6):3309-20. DM592FB RU https://pubmed.ncbi.nlm.nih.gov/18083579 DM592FB DI DM592FB DM592FB DN 6,7-dichloro-2,3,4,5-tetrahydro-1H-3-benzazepine DM592FB MI TTWJBZ5 DM592FB MN 5-HT 2C receptor (HTR2C) DM592FB MT DTT DM592FB MA Inhibitor DM592FB RN Synthesis and structure-activity relationships of a series of benzazepine derivatives as 5-HT2C receptor agonists. Bioorg Med Chem. 2008 Mar 15;16(6):3309-20. DM592FB RU https://pubmed.ncbi.nlm.nih.gov/18083579 DMNEJ8W DI DMNEJ8W DMNEJ8W DN 6,7-Dichloro-3-hydroxy-1H-quinazoline-2,4-dione DMNEJ8W MI TTLD29N DMNEJ8W MN Glutamate receptor ionotropic NMDA 1 (NMDAR1) DMNEJ8W MT DTT DMNEJ8W MA Inhibitor DMNEJ8W RN 3-hydroxy-quinazoline-2,4-dione as a useful scaffold to obtain selective Gly/NMDA and AMPA receptor antagonists. Bioorg Med Chem Lett. 2004 May 3;14(9):2345-9. DMNEJ8W RU https://pubmed.ncbi.nlm.nih.gov/15081038 DMNEJ8W DI DMNEJ8W DMNEJ8W DN 6,7-Dichloro-3-hydroxy-1H-quinazoline-2,4-dione DMNEJ8W MI TTKJEMQ DMNEJ8W MN Glutamate receptor ionotropic NMDA 2A (NMDAR2A) DMNEJ8W MT DTT DMNEJ8W MA Inhibitor DMNEJ8W RN 3-hydroxy-quinazoline-2,4-dione as a useful scaffold to obtain selective Gly/NMDA and AMPA receptor antagonists. Bioorg Med Chem Lett. 2004 May 3;14(9):2345-9. DMNEJ8W RU https://pubmed.ncbi.nlm.nih.gov/15081038 DMNEJ8W DI DMNEJ8W DMNEJ8W DN 6,7-Dichloro-3-hydroxy-1H-quinazoline-2,4-dione DMNEJ8W MI TTN9D8E DMNEJ8W MN Glutamate receptor ionotropic NMDA 2B (NMDAR2B) DMNEJ8W MT DTT DMNEJ8W MA Inhibitor DMNEJ8W RN 3-hydroxy-quinazoline-2,4-dione as a useful scaffold to obtain selective Gly/NMDA and AMPA receptor antagonists. Bioorg Med Chem Lett. 2004 May 3;14(9):2345-9. DMNEJ8W RU https://pubmed.ncbi.nlm.nih.gov/15081038 DMJNHSL DI DMJNHSL DMJNHSL DN 6,7-Dichloro-3-thiophen-3-yl-quinoline DMJNHSL MI TT8FYO9 DMJNHSL MN Platelet-derived growth factor receptor alpha (PDGFRA) DMJNHSL MT DTT DMJNHSL MA Inhibitor DMJNHSL RN A new series of PDGF receptor tyrosine kinase inhibitors: 3-substituted quinoline derivatives. J Med Chem. 1994 Jul 8;37(14):2129-37. DMJNHSL RU https://pubmed.ncbi.nlm.nih.gov/8035419 DMJNHSL DI DMJNHSL DMJNHSL DN 6,7-Dichloro-3-thiophen-3-yl-quinoline DMJNHSL MI TTI7421 DMJNHSL MN Platelet-derived growth factor receptor beta (PDGFRB) DMJNHSL MT DTT DMJNHSL MA Inhibitor DMJNHSL RN A new series of PDGF receptor tyrosine kinase inhibitors: 3-substituted quinoline derivatives. J Med Chem. 1994 Jul 8;37(14):2129-37. DMJNHSL RU https://pubmed.ncbi.nlm.nih.gov/8035419 DMI7FVJ DI DMI7FVJ DMI7FVJ DN 6,7-diethoxy-4-(4-phenylbut-1-enyl)quinazoline DMI7FVJ MI TTGKNB4 DMI7FVJ MN Epidermal growth factor receptor (EGFR) DMI7FVJ MT DTT DMI7FVJ MA Inhibitor DMI7FVJ RN Synthesis and inhibitory activity of 4-alkynyl and 4-alkenylquinazolines: identification of new scaffolds for potent EGFR tyrosine kinase inhibitors. Bioorg Med Chem Lett. 2007 Nov 1;17(21):5863-7. DMI7FVJ RU https://pubmed.ncbi.nlm.nih.gov/17869510 DMFVT8A DI DMFVT8A DMFVT8A DN 6,7-diethoxy-4-(5-phenylpent-1-enyl)quinazoline DMFVT8A MI TTGKNB4 DMFVT8A MN Epidermal growth factor receptor (EGFR) DMFVT8A MT DTT DMFVT8A MA Inhibitor DMFVT8A RN Synthesis and inhibitory activity of 4-alkynyl and 4-alkenylquinazolines: identification of new scaffolds for potent EGFR tyrosine kinase inhibitors. Bioorg Med Chem Lett. 2007 Nov 1;17(21):5863-7. DMFVT8A RU https://pubmed.ncbi.nlm.nih.gov/17869510 DMVR4OW DI DMVR4OW DMVR4OW DN 6,7-diethoxy-4-styrylquinazoline DMVR4OW MI TTGKNB4 DMVR4OW MN Epidermal growth factor receptor (EGFR) DMVR4OW MT DTT DMVR4OW MA Inhibitor DMVR4OW RN Synthesis and inhibitory activity of 4-alkynyl and 4-alkenylquinazolines: identification of new scaffolds for potent EGFR tyrosine kinase inhibitors. Bioorg Med Chem Lett. 2007 Nov 1;17(21):5863-7. DMVR4OW RU https://pubmed.ncbi.nlm.nih.gov/17869510 DMUZYXQ DI DMUZYXQ DMUZYXQ DN 6,7-Difluoro-3-thiophen-3-yl-quinoline DMUZYXQ MI TT8FYO9 DMUZYXQ MN Platelet-derived growth factor receptor alpha (PDGFRA) DMUZYXQ MT DTT DMUZYXQ MA Inhibitor DMUZYXQ RN A new series of PDGF receptor tyrosine kinase inhibitors: 3-substituted quinoline derivatives. J Med Chem. 1994 Jul 8;37(14):2129-37. DMUZYXQ RU https://pubmed.ncbi.nlm.nih.gov/8035419 DMUZYXQ DI DMUZYXQ DMUZYXQ DN 6,7-Difluoro-3-thiophen-3-yl-quinoline DMUZYXQ MI TTI7421 DMUZYXQ MN Platelet-derived growth factor receptor beta (PDGFRB) DMUZYXQ MT DTT DMUZYXQ MA Inhibitor DMUZYXQ RN A new series of PDGF receptor tyrosine kinase inhibitors: 3-substituted quinoline derivatives. J Med Chem. 1994 Jul 8;37(14):2129-37. DMUZYXQ RU https://pubmed.ncbi.nlm.nih.gov/8035419 DMF08UT DI DMF08UT DMF08UT DN 6,7-Dihydroxy-2-phenyl-chromen-4-one DMF08UT MI TTFBNVI DMF08UT MN Aldose reductase (AKR1B1) DMF08UT MT DTT DMF08UT MA Inhibitor DMF08UT RN 1-Benzopyran-4-one antioxidants as aldose reductase inhibitors. J Med Chem. 1999 Jun 3;42(11):1881-93. DMF08UT RU https://pubmed.ncbi.nlm.nih.gov/10354396 DM9JLUS DI DM9JLUS DM9JLUS DN 6,7-dihydroxy-8-nitro-1-tetralone DM9JLUS MI TTKWFB8 DM9JLUS MN Catechol-O-methyl-transferase (COMT) DM9JLUS MT DTT DM9JLUS MA Inhibitor DM9JLUS RN Synthesis and biological evaluation of a novel series of "ortho-nitrated" inhibitors of catechol-O-methyltransferase. J Med Chem. 2005 Dec 15;48(25):8070-8. DM9JLUS RU https://pubmed.ncbi.nlm.nih.gov/16335931 DMSM0QV DI DMSM0QV DMSM0QV DN 6,7-Dimethoxy-3-((E)-styryl)-quinoline DMSM0QV MI TT8FYO9 DMSM0QV MN Platelet-derived growth factor receptor alpha (PDGFRA) DMSM0QV MT DTT DMSM0QV MA Inhibitor DMSM0QV RN A new series of PDGF receptor tyrosine kinase inhibitors: 3-substituted quinoline derivatives. J Med Chem. 1994 Jul 8;37(14):2129-37. DMSM0QV RU https://pubmed.ncbi.nlm.nih.gov/8035419 DMSM0QV DI DMSM0QV DMSM0QV DN 6,7-Dimethoxy-3-((E)-styryl)-quinoline DMSM0QV MI TTI7421 DMSM0QV MN Platelet-derived growth factor receptor beta (PDGFRB) DMSM0QV MT DTT DMSM0QV MA Inhibitor DMSM0QV RN A new series of PDGF receptor tyrosine kinase inhibitors: 3-substituted quinoline derivatives. J Med Chem. 1994 Jul 8;37(14):2129-37. DMSM0QV RU https://pubmed.ncbi.nlm.nih.gov/8035419 DMPYGK9 DI DMPYGK9 DMPYGK9 DN 6,7-Dimethoxy-3-(2-methoxy-phenyl)-quinoline DMPYGK9 MI TT8FYO9 DMPYGK9 MN Platelet-derived growth factor receptor alpha (PDGFRA) DMPYGK9 MT DTT DMPYGK9 MA Inhibitor DMPYGK9 RN A new series of PDGF receptor tyrosine kinase inhibitors: 3-substituted quinoline derivatives. J Med Chem. 1994 Jul 8;37(14):2129-37. DMPYGK9 RU https://pubmed.ncbi.nlm.nih.gov/8035419 DMDENVF DI DMDENVF DMDENVF DN 6,7-Dimethoxy-3-(3-methoxy-phenyl)-quinoline DMDENVF MI TT8FYO9 DMDENVF MN Platelet-derived growth factor receptor alpha (PDGFRA) DMDENVF MT DTT DMDENVF MA Inhibitor DMDENVF RN A new series of PDGF receptor tyrosine kinase inhibitors: 3-substituted quinoline derivatives. J Med Chem. 1994 Jul 8;37(14):2129-37. DMDENVF RU https://pubmed.ncbi.nlm.nih.gov/8035419 DMDENVF DI DMDENVF DMDENVF DN 6,7-Dimethoxy-3-(3-methoxy-phenyl)-quinoline DMDENVF MI TTI7421 DMDENVF MN Platelet-derived growth factor receptor beta (PDGFRB) DMDENVF MT DTT DMDENVF MA Inhibitor DMDENVF RN A new series of PDGF receptor tyrosine kinase inhibitors: 3-substituted quinoline derivatives. J Med Chem. 1994 Jul 8;37(14):2129-37. DMDENVF RU https://pubmed.ncbi.nlm.nih.gov/8035419 DM12DVT DI DM12DVT DM12DVT DN 6,7-Dimethoxy-3-(4-methoxy-phenyl)-quinoline DM12DVT MI TT8FYO9 DM12DVT MN Platelet-derived growth factor receptor alpha (PDGFRA) DM12DVT MT DTT DM12DVT MA Inhibitor DM12DVT RN A new series of PDGF receptor tyrosine kinase inhibitors: 3-substituted quinoline derivatives. J Med Chem. 1994 Jul 8;37(14):2129-37. DM12DVT RU https://pubmed.ncbi.nlm.nih.gov/8035419 DM12DVT DI DM12DVT DM12DVT DN 6,7-Dimethoxy-3-(4-methoxy-phenyl)-quinoline DM12DVT MI TTI7421 DM12DVT MN Platelet-derived growth factor receptor beta (PDGFRB) DM12DVT MT DTT DM12DVT MA Inhibitor DM12DVT RN A new series of PDGF receptor tyrosine kinase inhibitors: 3-substituted quinoline derivatives. J Med Chem. 1994 Jul 8;37(14):2129-37. DM12DVT RU https://pubmed.ncbi.nlm.nih.gov/8035419 DMM7NHI DI DMM7NHI DMM7NHI DN 6,7-Dimethoxy-3-(4-nitro-phenyl)-quinoline DMM7NHI MI TT8FYO9 DMM7NHI MN Platelet-derived growth factor receptor alpha (PDGFRA) DMM7NHI MT DTT DMM7NHI MA Inhibitor DMM7NHI RN A new series of PDGF receptor tyrosine kinase inhibitors: 3-substituted quinoline derivatives. J Med Chem. 1994 Jul 8;37(14):2129-37. DMM7NHI RU https://pubmed.ncbi.nlm.nih.gov/8035419 DMM7NHI DI DMM7NHI DMM7NHI DN 6,7-Dimethoxy-3-(4-nitro-phenyl)-quinoline DMM7NHI MI TTI7421 DMM7NHI MN Platelet-derived growth factor receptor beta (PDGFRB) DMM7NHI MT DTT DMM7NHI MA Inhibitor DMM7NHI RN A new series of PDGF receptor tyrosine kinase inhibitors: 3-substituted quinoline derivatives. J Med Chem. 1994 Jul 8;37(14):2129-37. DMM7NHI RU https://pubmed.ncbi.nlm.nih.gov/8035419 DMFRXDT DI DMFRXDT DMFRXDT DN 6,7-Dimethoxy-3-phenylethynyl-quinoline DMFRXDT MI TT8FYO9 DMFRXDT MN Platelet-derived growth factor receptor alpha (PDGFRA) DMFRXDT MT DTT DMFRXDT MA Inhibitor DMFRXDT RN A new series of PDGF receptor tyrosine kinase inhibitors: 3-substituted quinoline derivatives. J Med Chem. 1994 Jul 8;37(14):2129-37. DMFRXDT RU https://pubmed.ncbi.nlm.nih.gov/8035419 DMFRXDT DI DMFRXDT DMFRXDT DN 6,7-Dimethoxy-3-phenylethynyl-quinoline DMFRXDT MI TTI7421 DMFRXDT MN Platelet-derived growth factor receptor beta (PDGFRB) DMFRXDT MT DTT DMFRXDT MA Inhibitor DMFRXDT RN A new series of PDGF receptor tyrosine kinase inhibitors: 3-substituted quinoline derivatives. J Med Chem. 1994 Jul 8;37(14):2129-37. DMFRXDT RU https://pubmed.ncbi.nlm.nih.gov/8035419 DM516B4 DI DM516B4 DM516B4 DN 6,7-Dimethoxy-3-phenyl-quinoline DM516B4 MI TT8FYO9 DM516B4 MN Platelet-derived growth factor receptor alpha (PDGFRA) DM516B4 MT DTT DM516B4 MA Inhibitor DM516B4 RN A new series of PDGF receptor tyrosine kinase inhibitors: 3-substituted quinoline derivatives. J Med Chem. 1994 Jul 8;37(14):2129-37. DM516B4 RU https://pubmed.ncbi.nlm.nih.gov/8035419 DM516B4 DI DM516B4 DM516B4 DN 6,7-Dimethoxy-3-phenyl-quinoline DM516B4 MI TTI7421 DM516B4 MN Platelet-derived growth factor receptor beta (PDGFRB) DM516B4 MT DTT DM516B4 MA Inhibitor DM516B4 RN A new series of PDGF receptor tyrosine kinase inhibitors: 3-substituted quinoline derivatives. J Med Chem. 1994 Jul 8;37(14):2129-37. DM516B4 RU https://pubmed.ncbi.nlm.nih.gov/8035419 DMM7IAK DI DMM7IAK DMM7IAK DN 6,7-Dimethoxy-3-p-tolyl-quinoline DMM7IAK MI TT8FYO9 DMM7IAK MN Platelet-derived growth factor receptor alpha (PDGFRA) DMM7IAK MT DTT DMM7IAK MA Inhibitor DMM7IAK RN A new series of PDGF receptor tyrosine kinase inhibitors: 3-substituted quinoline derivatives. J Med Chem. 1994 Jul 8;37(14):2129-37. DMM7IAK RU https://pubmed.ncbi.nlm.nih.gov/8035419 DMM7IAK DI DMM7IAK DMM7IAK DN 6,7-Dimethoxy-3-p-tolyl-quinoline DMM7IAK MI TTI7421 DMM7IAK MN Platelet-derived growth factor receptor beta (PDGFRB) DMM7IAK MT DTT DMM7IAK MA Inhibitor DMM7IAK RN A new series of PDGF receptor tyrosine kinase inhibitors: 3-substituted quinoline derivatives. J Med Chem. 1994 Jul 8;37(14):2129-37. DMM7IAK RU https://pubmed.ncbi.nlm.nih.gov/8035419 DMSG1AY DI DMSG1AY DMSG1AY DN 6,7-Dimethoxy-3-pyridin-3-yl-quinoline DMSG1AY MI TT8FYO9 DMSG1AY MN Platelet-derived growth factor receptor alpha (PDGFRA) DMSG1AY MT DTT DMSG1AY MA Inhibitor DMSG1AY RN A new series of PDGF receptor tyrosine kinase inhibitors: 3-substituted quinoline derivatives. J Med Chem. 1994 Jul 8;37(14):2129-37. DMSG1AY RU https://pubmed.ncbi.nlm.nih.gov/8035419 DMSG1AY DI DMSG1AY DMSG1AY DN 6,7-Dimethoxy-3-pyridin-3-yl-quinoline DMSG1AY MI TTI7421 DMSG1AY MN Platelet-derived growth factor receptor beta (PDGFRB) DMSG1AY MT DTT DMSG1AY MA Inhibitor DMSG1AY RN A new series of PDGF receptor tyrosine kinase inhibitors: 3-substituted quinoline derivatives. J Med Chem. 1994 Jul 8;37(14):2129-37. DMSG1AY RU https://pubmed.ncbi.nlm.nih.gov/8035419 DMW7K5P DI DMW7K5P DMW7K5P DN 6,7-Dimethoxy-3-pyridin-4-yl-quinoline DMW7K5P MI TT8FYO9 DMW7K5P MN Platelet-derived growth factor receptor alpha (PDGFRA) DMW7K5P MT DTT DMW7K5P MA Inhibitor DMW7K5P RN 5,7-Dimethoxy-3-(4-pyridinyl)quinoline is a potent and selective inhibitor of human vascular beta-type platelet-derived growth factor receptor tyro... J Med Chem. 1994 Aug 19;37(17):2627-9. DMW7K5P RU https://pubmed.ncbi.nlm.nih.gov/8064792 DMW7K5P DI DMW7K5P DMW7K5P DN 6,7-Dimethoxy-3-pyridin-4-yl-quinoline DMW7K5P MI TTI7421 DMW7K5P MN Platelet-derived growth factor receptor beta (PDGFRB) DMW7K5P MT DTT DMW7K5P MA Inhibitor DMW7K5P RN 5,7-Dimethoxy-3-(4-pyridinyl)quinoline is a potent and selective inhibitor of human vascular beta-type platelet-derived growth factor receptor tyro... J Med Chem. 1994 Aug 19;37(17):2627-9. DMW7K5P RU https://pubmed.ncbi.nlm.nih.gov/8064792 DM6WD8T DI DM6WD8T DM6WD8T DN 6,7-Dimethoxy-3-thiophen-2-yl-quinoline DM6WD8T MI TT8FYO9 DM6WD8T MN Platelet-derived growth factor receptor alpha (PDGFRA) DM6WD8T MT DTT DM6WD8T MA Inhibitor DM6WD8T RN A new series of PDGF receptor tyrosine kinase inhibitors: 3-substituted quinoline derivatives. J Med Chem. 1994 Jul 8;37(14):2129-37. DM6WD8T RU https://pubmed.ncbi.nlm.nih.gov/8035419 DM6WD8T DI DM6WD8T DM6WD8T DN 6,7-Dimethoxy-3-thiophen-2-yl-quinoline DM6WD8T MI TTI7421 DM6WD8T MN Platelet-derived growth factor receptor beta (PDGFRB) DM6WD8T MT DTT DM6WD8T MA Inhibitor DM6WD8T RN A new series of PDGF receptor tyrosine kinase inhibitors: 3-substituted quinoline derivatives. J Med Chem. 1994 Jul 8;37(14):2129-37. DM6WD8T RU https://pubmed.ncbi.nlm.nih.gov/8035419 DMU15YV DI DMU15YV DMU15YV DN 6,7-Dimethoxy-4-(2-methoxy-phenoxy)-quinoline DMU15YV MI TTI7421 DMU15YV MN Platelet-derived growth factor receptor beta (PDGFRB) DMU15YV MT DTT DMU15YV MA Inhibitor DMU15YV RN A novel series of 4-phenoxyquinolines: potent and highly selective inhibitors of PDGF receptor autophosphorylation, Bioorg. Med. Chem. Lett. 7(23):2935-2940 (1997). DMU15YV RU http://www.sciencedirect.com/science/article/pii/S0960894X97101172 DMQTHV7 DI DMQTHV7 DMQTHV7 DN 6,7-dimethoxy-4-(2-phenylethynyl)quinazoline DMQTHV7 MI TTGKNB4 DMQTHV7 MN Epidermal growth factor receptor (EGFR) DMQTHV7 MT DTT DMQTHV7 MA Inhibitor DMQTHV7 RN Synthesis and inhibitory activity of 4-alkynyl and 4-alkenylquinazolines: identification of new scaffolds for potent EGFR tyrosine kinase inhibitors. Bioorg Med Chem Lett. 2007 Nov 1;17(21):5863-7. DMQTHV7 RU https://pubmed.ncbi.nlm.nih.gov/17869510 DMPS2GX DI DMPS2GX DMPS2GX DN 6,7-Dimethoxy-4-(3-methoxy-phenoxy)-quinoline DMPS2GX MI TTI7421 DMPS2GX MN Platelet-derived growth factor receptor beta (PDGFRB) DMPS2GX MT DTT DMPS2GX MA Inhibitor DMPS2GX RN A novel series of 4-phenoxyquinolines: potent and highly selective inhibitors of PDGF receptor autophosphorylation, Bioorg. Med. Chem. Lett. 7(23):2935-2940 (1997). DMPS2GX RU http://www.sciencedirect.com/science/article/pii/S0960894X97101172 DM3YSNX DI DM3YSNX DM3YSNX DN 6,7-Dimethoxy-4-(3-nitro-phenoxy)-quinoline DM3YSNX MI TTI7421 DM3YSNX MN Platelet-derived growth factor receptor beta (PDGFRB) DM3YSNX MT DTT DM3YSNX MA Inhibitor DM3YSNX RN A novel series of 4-phenoxyquinolines: potent and highly selective inhibitors of PDGF receptor autophosphorylation, Bioorg. Med. Chem. Lett. 7(23):2935-2940 (1997). DM3YSNX RU http://www.sciencedirect.com/science/article/pii/S0960894X97101172 DMKO8QT DI DMKO8QT DMKO8QT DN 6,7-dimethoxy-4-(3-phenoxyprop-1-ynyl)quinazoline DMKO8QT MI TTGKNB4 DMKO8QT MN Epidermal growth factor receptor (EGFR) DMKO8QT MT DTT DMKO8QT MA Inhibitor DMKO8QT RN Synthesis and inhibitory activity of 4-alkynyl and 4-alkenylquinazolines: identification of new scaffolds for potent EGFR tyrosine kinase inhibitors. Bioorg Med Chem Lett. 2007 Nov 1;17(21):5863-7. DMKO8QT RU https://pubmed.ncbi.nlm.nih.gov/17869510 DMX2VFP DI DMX2VFP DMX2VFP DN 6,7-Dimethoxy-4-(4-methoxy-phenoxy)-quinoline DMX2VFP MI TTI7421 DMX2VFP MN Platelet-derived growth factor receptor beta (PDGFRB) DMX2VFP MT DTT DMX2VFP MA Inhibitor DMX2VFP RN A novel series of 4-phenoxyquinolines: potent and highly selective inhibitors of PDGF receptor autophosphorylation, Bioorg. Med. Chem. Lett. 7(23):2935-2940 (1997). DMX2VFP RU http://www.sciencedirect.com/science/article/pii/S0960894X97101172 DMBI40Y DI DMBI40Y DMBI40Y DN 6,7-dimethoxy-4-(4-phenylbut-1-ynyl)quinazoline DMBI40Y MI TTGKNB4 DMBI40Y MN Epidermal growth factor receptor (EGFR) DMBI40Y MT DTT DMBI40Y MA Inhibitor DMBI40Y RN Synthesis and inhibitory activity of 4-alkynyl and 4-alkenylquinazolines: identification of new scaffolds for potent EGFR tyrosine kinase inhibitors. Bioorg Med Chem Lett. 2007 Nov 1;17(21):5863-7. DMBI40Y RU https://pubmed.ncbi.nlm.nih.gov/17869510 DMEMGPU DI DMEMGPU DMEMGPU DN 6,7-Dimethoxy-4-m-tolyloxy-quinoline DMEMGPU MI TTI7421 DMEMGPU MN Platelet-derived growth factor receptor beta (PDGFRB) DMEMGPU MT DTT DMEMGPU MA Inhibitor DMEMGPU RN A novel series of 4-phenoxyquinolines: potent and highly selective inhibitors of PDGF receptor autophosphorylation, Bioorg. Med. Chem. Lett. 7(23):2935-2940 (1997). DMEMGPU RU http://www.sciencedirect.com/science/article/pii/S0960894X97101172 DMBZP3I DI DMBZP3I DMBZP3I DN 6,7-Dimethoxy-4-phenoxy-quinoline DMBZP3I MI TTI7421 DMBZP3I MN Platelet-derived growth factor receptor beta (PDGFRB) DMBZP3I MT DTT DMBZP3I MA Inhibitor DMBZP3I RN A novel series of 4-phenoxyquinolines: potent and highly selective inhibitors of PDGF receptor autophosphorylation, Bioorg. Med. Chem. Lett. 7(23):2935-2940 (1997). DMBZP3I RU http://www.sciencedirect.com/science/article/pii/S0960894X97101172 DMP8LXB DI DMP8LXB DMP8LXB DN 6,7-dimethoxy-N-m-tolylquinazolin-4-amine DMP8LXB MI TTGKNB4 DMP8LXB MN Epidermal growth factor receptor (EGFR) DMP8LXB MT DTT DMP8LXB MA Inhibitor DMP8LXB RN Computational studies of epidermal growth factor receptor: docking reliability, three-dimensional quantitative structure-activity relationship anal... J Med Chem. 2009 Feb 26;52(4):964-75. DMP8LXB RU https://pubmed.ncbi.nlm.nih.gov/19170633 DM7U8ID DI DM7U8ID DM7U8ID DN 6,7-Diphenyl-pteridine-2,4-diamine DM7U8ID MI TT9SL3Q DM7U8ID MN Polypeptide deformylase (PDF) DM7U8ID MT DTT DM7U8ID MA Inhibitor DM7U8ID RN Further studies on 2,4-diamino-5-(2',5'-disubstituted benzyl)pyrimidines as potent and selective inhibitors of dihydrofolate reductases from three ... J Med Chem. 2003 Apr 24;46(9):1726-36. DM7U8ID RU https://pubmed.ncbi.nlm.nih.gov/12699390 DMT09YC DI DMT09YC DMT09YC DN 6,7'-oxybis(2-phenyl-4H-chromen-4-one) DMT09YC MI TTVKILB DMT09YC MN Prostaglandin G/H synthase 2 (COX-2) DMT09YC MT DTT DMT09YC MA Inhibitor DMT09YC RN Synthesis of biflavones having a 6-O-7'' linkage and effects on cyclooxygenase-2 and inducible nitric oxide synthase. Bioorg Med Chem Lett. 2009 Jan 1;19(1):74-6. DMT09YC RU https://pubmed.ncbi.nlm.nih.gov/19041241 DMUEFDM DI DMUEFDM DMUEFDM DN 6,8-Dichloro-1,2,3,4-tetrahydro-acridin-9-ylamine DMUEFDM MI TT1RS9F DMUEFDM MN Acetylcholinesterase (AChE) DMUEFDM MT DTT DMUEFDM MA Inhibitor DMUEFDM RN Novel and potent tacrine-related hetero- and homobivalent ligands for acetylcholinesterase and butyrylcholinesterase. Bioorg Med Chem Lett. 2001 Jul 9;11(13):1779-82. DMUEFDM RU https://pubmed.ncbi.nlm.nih.gov/11425559 DMAFP18 DI DMAFP18 DMAFP18 DN 6,8-Dimethoxy-1,4-dimethylquinolin-2(1H)-one DMAFP18 MI TTJLP0R DMAFP18 MN Quinone reductase 2 (NQO2) DMAFP18 MT DTT DMAFP18 MA Inhibitor DMAFP18 RN Synthesis of casimiroin and optimization of its quinone reductase 2 and aromatase inhibitory activities. J Med Chem. 2009 Apr 9;52(7):1873-84. DMAFP18 RU https://pubmed.ncbi.nlm.nih.gov/19265439 DMYKSTZ DI DMYKSTZ DMYKSTZ DN 6,8-Dimethoxy-4-methylquinolin-2(1H)-one DMYKSTZ MI TTJLP0R DMYKSTZ MN Quinone reductase 2 (NQO2) DMYKSTZ MT DTT DMYKSTZ MA Inhibitor DMYKSTZ RN Synthesis of casimiroin and optimization of its quinone reductase 2 and aromatase inhibitory activities. J Med Chem. 2009 Apr 9;52(7):1873-84. DMYKSTZ RU https://pubmed.ncbi.nlm.nih.gov/19265439 DME4193 DI DME4193 DME4193 DN 6,8-Dinitro-2-piperazin-1-yl-quinoline DME4193 MI TT3ROYC DME4193 MN Serotonin transporter (SERT) DME4193 MT DTT DME4193 MA Inhibitor DME4193 RN Syntheses and binding affinities of 6-nitroquipazine analogues for serotonin transporter. Part 1. Bioorg Med Chem Lett. 2000 Jul 17;10(14):1559-62. DME4193 RU https://pubmed.ncbi.nlm.nih.gov/10915050 DM7FMWS DI DM7FMWS DM7FMWS DN 6,9-Dimethyl-2-oxa-spiro[4.4]nonan-1-one DM7FMWS MI TT1MPAY DM7FMWS MN GABA(A) receptor alpha-1 (GABRA1) DM7FMWS MT DTT DM7FMWS MA Inhibitor DM7FMWS RN Alpha-spirocyclopentyl- and alpha-spirocyclopropyl-gamma-butyrolactones: conformationally constrained derivatives of anticonvulsant and convulsant ... J Med Chem. 1994 Jan 21;37(2):275-86. DM7FMWS RU https://pubmed.ncbi.nlm.nih.gov/8295215 DM7FMWS DI DM7FMWS DM7FMWS DN 6,9-Dimethyl-2-oxa-spiro[4.4]nonan-1-one DM7FMWS MI TTZA1NY DM7FMWS MN GABA(A) receptor beta-2 (GABRB2) DM7FMWS MT DTT DM7FMWS MA Inhibitor DM7FMWS RN Alpha-spirocyclopentyl- and alpha-spirocyclopropyl-gamma-butyrolactones: conformationally constrained derivatives of anticonvulsant and convulsant ... J Med Chem. 1994 Jan 21;37(2):275-86. DM7FMWS RU https://pubmed.ncbi.nlm.nih.gov/8295215 DM7FMWS DI DM7FMWS DM7FMWS DN 6,9-Dimethyl-2-oxa-spiro[4.4]nonan-1-one DM7FMWS MI TT06RH5 DM7FMWS MN GABA(A) receptor gamma-2 (GABRG2) DM7FMWS MT DTT DM7FMWS MA Inhibitor DM7FMWS RN Alpha-spirocyclopentyl- and alpha-spirocyclopropyl-gamma-butyrolactones: conformationally constrained derivatives of anticonvulsant and convulsant ... J Med Chem. 1994 Jan 21;37(2):275-86. DM7FMWS RU https://pubmed.ncbi.nlm.nih.gov/8295215 DM7FMWS DI DM7FMWS DM7FMWS DN 6,9-Dimethyl-2-oxa-spiro[4.4]nonan-1-one DM7FMWS MI TTNJYV2 DM7FMWS MN Gamma-aminobutyric acid receptor (GAR) DM7FMWS MT DTT DM7FMWS MA Inhibitor DM7FMWS RN Alpha-spirocyclopentyl- and alpha-spirocyclopropyl-gamma-butyrolactones: conformationally constrained derivatives of anticonvulsant and convulsant ... J Med Chem. 1994 Jan 21;37(2):275-86. DM7FMWS RU https://pubmed.ncbi.nlm.nih.gov/8295215 DMDNG8F DI DMDNG8F DMDNG8F DN 6-[(E)-2-(4-Fluoro-phenyl)-vinyl]-9H-purine DMDNG8F MI TT1MG9E DMDNG8F MN Extracellular signal-regulated kinase 1 (ERK1) DMDNG8F MT DTT DMDNG8F MA Inhibitor DMDNG8F RN Synthesis and biological testing of purine derivatives as potential ATP-competitive kinase inhibitors. J Med Chem. 2005 Feb 10;48(3):710-22. DMDNG8F RU https://pubmed.ncbi.nlm.nih.gov/15689155 DMDNG8F DI DMDNG8F DMDNG8F DN 6-[(E)-2-(4-Fluoro-phenyl)-vinyl]-9H-purine DMDNG8F MI TTAN5W2 DMDNG8F MN Raf messenger RNA (Raf mRNA) DMDNG8F MT DTT DMDNG8F MA Inhibitor DMDNG8F RN Synthesis and biological testing of purine derivatives as potential ATP-competitive kinase inhibitors. J Med Chem. 2005 Feb 10;48(3):710-22. DMDNG8F RU https://pubmed.ncbi.nlm.nih.gov/15689155 DMNJPCD DI DMNJPCD DMNJPCD DN 6-[2-(1H-INDOL-6-YL)ETHYL]PYRIDIN-2-AMINE DMNJPCD MI TT8JRS7 DMNJPCD MN Beta-secretase (BACE) DMNJPCD MT DTT DMNJPCD MA Inhibitor DMNJPCD RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DMNJPCD RU https://pubmed.ncbi.nlm.nih.gov/10592235 DM40LQ9 DI DM40LQ9 DM40LQ9 DN 6-[4-(Pyridin-4-ylmethyl)phenyl]naphthalen-2-ol DM40LQ9 MI TTIQUX7 DM40LQ9 MN Steroid 11-beta-hydroxylase (CYP11B1) DM40LQ9 MT DTT DM40LQ9 MA Inhibitor DM40LQ9 RN Replacement of imidazolyl by pyridyl in biphenylmethylenes results in selective CYP17 and dual CYP17/CYP11B1 inhibitors for the treatment of prosta... J Med Chem. 2010 Aug 12;53(15):5749-58. DM40LQ9 RU https://pubmed.ncbi.nlm.nih.gov/20684610 DM40LQ9 DI DM40LQ9 DM40LQ9 DN 6-[4-(Pyridin-4-ylmethyl)phenyl]naphthalen-2-ol DM40LQ9 MI TTRA5BZ DM40LQ9 MN Steroid 17-alpha-monooxygenase (S17AH) DM40LQ9 MT DTT DM40LQ9 MA Inhibitor DM40LQ9 RN Replacement of imidazolyl by pyridyl in biphenylmethylenes results in selective CYP17 and dual CYP17/CYP11B1 inhibitors for the treatment of prosta... J Med Chem. 2010 Aug 12;53(15):5749-58. DM40LQ9 RU https://pubmed.ncbi.nlm.nih.gov/20684610 DM1G7P9 DI DM1G7P9 DM1G7P9 DN 6-{[(CYCLOHEXYLAMINO)CARBONYL]AMINO}HEXANOIC ACID DM1G7P9 MI TT7WVHI DM1G7P9 MN Soluble epoxide hydrolase (EPHX2) DM1G7P9 MT DTT DM1G7P9 MA Inhibitor DM1G7P9 RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DM1G7P9 RU https://pubmed.ncbi.nlm.nih.gov/10592235 DM7D52Z DI DM7D52Z DM7D52Z DN 677T DM7D52Z MI TTQWOU1 DM7D52Z MN MTHFR messenger RNA (MTHFR mRNA) DM7D52Z MT DTT DM7D52Z RN Therapeutic target database update 2012: a resource for facilitating target-oriented drug discovery. Nucleic Acids Res. 2012 Jan;40(Database issue):D1128-36. DM7D52Z RU https://pubmed.ncbi.nlm.nih.gov/21948793 DMERKGH DI DMERKGH DMERKGH DN 6-Acetyl-7-ethoxy-2H-chromen-2-one DMERKGH MI TT2LVK8 DMERKGH MN Carbonic anhydrase IX (CA-IX) DMERKGH MT DTT DMERKGH MA Inhibitor DMERKGH RN 7,8-disubstituted- but not 6,7-disubstituted coumarins selectively inhibit the transmembrane, tumor-associated carbonic anhydrase isoforms IX and X... Bioorg Med Chem Lett. 2010 Dec 15;20(24):7255-8. DMERKGH RU https://pubmed.ncbi.nlm.nih.gov/21067924 DM1K0E2 DI DM1K0E2 DM1K0E2 DN 6-Acetyl-7-hydroxy-2H-chromen-2-one DM1K0E2 MI TT2LVK8 DM1K0E2 MN Carbonic anhydrase IX (CA-IX) DM1K0E2 MT DTT DM1K0E2 MA Inhibitor DM1K0E2 RN 7,8-disubstituted- but not 6,7-disubstituted coumarins selectively inhibit the transmembrane, tumor-associated carbonic anhydrase isoforms IX and X... Bioorg Med Chem Lett. 2010 Dec 15;20(24):7255-8. DM1K0E2 RU https://pubmed.ncbi.nlm.nih.gov/21067924 DMXOB2K DI DMXOB2K DMXOB2K DN 6-acetyl-7-methoxy-2H-chromen-2-one DMXOB2K MI TT2LVK8 DMXOB2K MN Carbonic anhydrase IX (CA-IX) DMXOB2K MT DTT DMXOB2K MA Inhibitor DMXOB2K RN 7,8-disubstituted- but not 6,7-disubstituted coumarins selectively inhibit the transmembrane, tumor-associated carbonic anhydrase isoforms IX and X... Bioorg Med Chem Lett. 2010 Dec 15;20(24):7255-8. DMXOB2K RU https://pubmed.ncbi.nlm.nih.gov/21067924 DMCG8BJ DI DMCG8BJ DMCG8BJ DN 6-acetyl-7-propoxy-2H-chromen-2-one DMCG8BJ MI TT2LVK8 DMCG8BJ MN Carbonic anhydrase IX (CA-IX) DMCG8BJ MT DTT DMCG8BJ MA Inhibitor DMCG8BJ RN 7,8-disubstituted- but not 6,7-disubstituted coumarins selectively inhibit the transmembrane, tumor-associated carbonic anhydrase isoforms IX and X... Bioorg Med Chem Lett. 2010 Dec 15;20(24):7255-8. DMCG8BJ RU https://pubmed.ncbi.nlm.nih.gov/21067924 DMI2XUQ DI DMI2XUQ DMI2XUQ DN 6-Allyloxy-9H-purin-2-ylamine DMI2XUQ MI TTJ8DV7 DMI2XUQ MN O-6-methylguanine-DNA-alkyltransferase (MGMT) DMI2XUQ MT DTT DMI2XUQ MA Inhibitor DMI2XUQ RN Resistance-modifying agents. 8. Inhibition of O(6)-alkylguanine-DNA alkyltransferase by O(6)-alkenyl-, O(6)-cycloalkenyl-, and O(6)-(2-oxoalkyl)gua... J Med Chem. 2000 Nov 2;43(22):4071-83. DMI2XUQ RU https://pubmed.ncbi.nlm.nih.gov/11063604 DMMUE05 DI DMMUE05 DMMUE05 DN 6-Amino-2-(1H-imidazol-4-yl)-hexanoic acid DMMUE05 MI TTP18AY DMMUE05 MN Carboxypeptidase B2 (CPB2) DMMUE05 MT DTT DMMUE05 MA Inhibitor DMMUE05 RN Imidazole acetic acid TAFIa inhibitors: SAR studies centered around the basic P(1)(') group. Bioorg Med Chem Lett. 2004 May 3;14(9):2141-5. DMMUE05 RU https://pubmed.ncbi.nlm.nih.gov/15080996 DMC5M76 DI DMC5M76 DMC5M76 DN 6-amino-4-trifluoromethylquinolin-2(1H)-one DMC5M76 MI TTKPW01 DMC5M76 MN Androgen receptor messenger RNA (AR mRNA) DMC5M76 MT DTT DMC5M76 MA Inhibitor DMC5M76 RN Discovery of 6-N,N-bis(2,2,2-trifluoroethyl)amino- 4-trifluoromethylquinolin-2(1H)-one as a novel selective androgen receptor modulator. J Med Chem. 2006 Oct 19;49(21):6143-6. DMC5M76 RU https://pubmed.ncbi.nlm.nih.gov/17034117 DM5SZHR DI DM5SZHR DM5SZHR DN 6-amino-5-bromouracil DM5SZHR MI TTO0IB8 DM5SZHR MN Thymidine phosphorylase (TYMP) DM5SZHR MT DTT DM5SZHR MA Inhibitor DM5SZHR RN Xanthine oxidase-activated prodrugs of thymidine phosphorylase inhibitors. Eur J Med Chem. 2008 Jun;43(6):1248-60. DM5SZHR RU https://pubmed.ncbi.nlm.nih.gov/17870212 DMFPCSJ DI DMFPCSJ DMFPCSJ DN 6-amino-5-chlorouracil hydrochloride DMFPCSJ MI TTO0IB8 DMFPCSJ MN Thymidine phosphorylase (TYMP) DMFPCSJ MT DTT DMFPCSJ MA Inhibitor DMFPCSJ RN Design and synthesis of novel 5,6-disubstituted uracil derivatives as potent inhibitors of thymidine phosphorylase. Bioorg Med Chem Lett. 2006 Mar 1;16(5):1335-7. DMFPCSJ RU https://pubmed.ncbi.nlm.nih.gov/16337119 DMU1CV4 DI DMU1CV4 DMU1CV4 DN 6-amino-9-methoxy-7H-furo[3,2-g]chromen-7-one DMU1CV4 MI TT3WG5C DMU1CV4 MN Monoamine oxidase type A (MAO-A) DMU1CV4 MT DTT DMU1CV4 MA Inhibitor DMU1CV4 RN Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors. J Med Chem. 2008 Nov 13;51(21):6740-51. DMU1CV4 RU https://pubmed.ncbi.nlm.nih.gov/18834112 DMU1CV4 DI DMU1CV4 DMU1CV4 DN 6-amino-9-methoxy-7H-furo[3,2-g]chromen-7-one DMU1CV4 MI TTGP7BY DMU1CV4 MN Monoamine oxidase type B (MAO-B) DMU1CV4 MT DTT DMU1CV4 MA Inhibitor DMU1CV4 RN Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors. J Med Chem. 2008 Nov 13;51(21):6740-51. DMU1CV4 RU https://pubmed.ncbi.nlm.nih.gov/18834112 DMWPELS DI DMWPELS DMWPELS DN 6-Amino-benzothiazole-2-sulfonic acid amide DMWPELS MI TTHQPL7 DMWPELS MN Carbonic anhydrase I (CA-I) DMWPELS MT DTT DMWPELS MA Inhibitor DMWPELS RN Carbonic anhydrase inhibitors. Synthesis of water-soluble, topically effective, intraocular pressure-lowering aromatic/heterocyclic sulfonamides co... J Med Chem. 1999 Jul 15;42(14):2641-50. DMWPELS RU https://pubmed.ncbi.nlm.nih.gov/10411484 DMWPELS DI DMWPELS DMWPELS DN 6-Amino-benzothiazole-2-sulfonic acid amide DMWPELS MI TTANPDJ DMWPELS MN Carbonic anhydrase II (CA-II) DMWPELS MT DTT DMWPELS MA Inhibitor DMWPELS RN Carbonic anhydrase inhibitors. Synthesis of water-soluble, topically effective, intraocular pressure-lowering aromatic/heterocyclic sulfonamides co... J Med Chem. 1999 Jul 15;42(14):2641-50. DMWPELS RU https://pubmed.ncbi.nlm.nih.gov/10411484 DMEHG2F DI DMEHG2F DMEHG2F DN 6-amino-N-(2,4-dichlorobenzyl)nicotinamide DMEHG2F MI TT7WVHI DMEHG2F MN Soluble epoxide hydrolase (EPHX2) DMEHG2F MT DTT DMEHG2F MA Inhibitor DMEHG2F RN Design and synthesis of substituted nicotinamides as inhibitors of soluble epoxide hydrolase. Bioorg Med Chem Lett. 2009 Oct 15;19(20):5864-8. DMEHG2F RU https://pubmed.ncbi.nlm.nih.gov/19758802 DMYI5GU DI DMYI5GU DMYI5GU DN 6-amino-N-(3,3-diphenylpropyl)nicotinamide DMYI5GU MI TT7WVHI DMYI5GU MN Soluble epoxide hydrolase (EPHX2) DMYI5GU MT DTT DMYI5GU MA Inhibitor DMYI5GU RN Design and synthesis of substituted nicotinamides as inhibitors of soluble epoxide hydrolase. Bioorg Med Chem Lett. 2009 Oct 15;19(20):5864-8. DMYI5GU RU https://pubmed.ncbi.nlm.nih.gov/19758802 DMUZOYN DI DMUZOYN DMUZOYN DN 6-amino-uridine monophosphate DMUZOYN MI TTV7Y40 DMUZOYN MN Mycobacterium Orotidine phosphate decarboxylase (MycB pyrF) DMUZOYN MT DTT DMUZOYN MA Inhibitor DMUZOYN RN Design of inhibitors of orotidine monophosphate decarboxylase using bioisosteric replacement and determination of inhibition kinetics. J Med Chem. 2006 Aug 10;49(16):4937-45. DMUZOYN RU https://pubmed.ncbi.nlm.nih.gov/16884305 DM7WYCM DI DM7WYCM DM7WYCM DN 6-aza-uridine monophosphate DM7WYCM MI TTV7Y40 DM7WYCM MN Mycobacterium Orotidine phosphate decarboxylase (MycB pyrF) DM7WYCM MT DTT DM7WYCM MA Inhibitor DM7WYCM RN Design of inhibitors of orotidine monophosphate decarboxylase using bioisosteric replacement and determination of inhibition kinetics. J Med Chem. 2006 Aug 10;49(16):4937-45. DM7WYCM RU https://pubmed.ncbi.nlm.nih.gov/16884305 DM8BNWH DI DM8BNWH DM8BNWH DN 6-Azido-8-(3-iodo-phenyl)-quinoline DM8BNWH MI TTZ97H5 DM8BNWH MN Phosphodiesterase 4A (PDE4A) DM8BNWH MT DTT DM8BNWH MA Inhibitor DM8BNWH RN Hunting the emesis and efficacy targets of PDE4 inhibitors: identification of the photoaffinity probe 8-(3-azidophenyl)-6- [(4-iodo-1H-1-imidazolyl... J Med Chem. 2000 Oct 19;43(21):3820-3. DM8BNWH RU https://pubmed.ncbi.nlm.nih.gov/11052785 DM2I95Z DI DM2I95Z DM2I95Z DN 6-benzenesulfinylhexanoic acid hydroxamide DM2I95Z MI TTBH0VX DM2I95Z MN Histone deacetylase (HDAC) DM2I95Z MT DTT DM2I95Z MA Inhibitor DM2I95Z RN Aromatic sulfide inhibitors of histone deacetylase based on arylsulfinyl-2,4-hexadienoic acid hydroxyamides. J Med Chem. 2006 Jan 26;49(2):800-5. DM2I95Z RU https://pubmed.ncbi.nlm.nih.gov/16420064 DM2I95Z DI DM2I95Z DM2I95Z DN 6-benzenesulfinylhexanoic acid hydroxamide DM2I95Z MI TT6R7JZ DM2I95Z MN Histone deacetylase 1 (HDAC1) DM2I95Z MT DTT DM2I95Z MA Inhibitor DM2I95Z RN Aromatic sulfide inhibitors of histone deacetylase based on arylsulfinyl-2,4-hexadienoic acid hydroxyamides. J Med Chem. 2006 Jan 26;49(2):800-5. DM2I95Z RU https://pubmed.ncbi.nlm.nih.gov/16420064 DM2I95Z DI DM2I95Z DM2I95Z DN 6-benzenesulfinylhexanoic acid hydroxamide DM2I95Z MI TTYHPU6 DM2I95Z MN Histone deacetylase 10 (HDAC10) DM2I95Z MT DTT DM2I95Z MA Inhibitor DM2I95Z RN Aromatic sulfide inhibitors of histone deacetylase based on arylsulfinyl-2,4-hexadienoic acid hydroxyamides. J Med Chem. 2006 Jan 26;49(2):800-5. DM2I95Z RU https://pubmed.ncbi.nlm.nih.gov/16420064 DM2I95Z DI DM2I95Z DM2I95Z DN 6-benzenesulfinylhexanoic acid hydroxamide DM2I95Z MI TTSHTOI DM2I95Z MN Histone deacetylase 2 (HDAC2) DM2I95Z MT DTT DM2I95Z MA Inhibitor DM2I95Z RN Aromatic sulfide inhibitors of histone deacetylase based on arylsulfinyl-2,4-hexadienoic acid hydroxyamides. J Med Chem. 2006 Jan 26;49(2):800-5. DM2I95Z RU https://pubmed.ncbi.nlm.nih.gov/16420064 DM2I95Z DI DM2I95Z DM2I95Z DN 6-benzenesulfinylhexanoic acid hydroxamide DM2I95Z MI TTTQGH8 DM2I95Z MN Histone deacetylase 4 (HDAC4) DM2I95Z MT DTT DM2I95Z MA Inhibitor DM2I95Z RN Aromatic sulfide inhibitors of histone deacetylase based on arylsulfinyl-2,4-hexadienoic acid hydroxyamides. J Med Chem. 2006 Jan 26;49(2):800-5. DM2I95Z RU https://pubmed.ncbi.nlm.nih.gov/16420064 DM2I95Z DI DM2I95Z DM2I95Z DN 6-benzenesulfinylhexanoic acid hydroxamide DM2I95Z MI TT5ZKDI DM2I95Z MN Histone deacetylase 6 (HDAC6) DM2I95Z MT DTT DM2I95Z MA Inhibitor DM2I95Z RN Aromatic sulfide inhibitors of histone deacetylase based on arylsulfinyl-2,4-hexadienoic acid hydroxyamides. J Med Chem. 2006 Jan 26;49(2):800-5. DM2I95Z RU https://pubmed.ncbi.nlm.nih.gov/16420064 DM2I95Z DI DM2I95Z DM2I95Z DN 6-benzenesulfinylhexanoic acid hydroxamide DM2I95Z MI TTT6LFV DM2I95Z MN Histone deacetylase 8 (HDAC8) DM2I95Z MT DTT DM2I95Z MA Inhibitor DM2I95Z RN Aromatic sulfide inhibitors of histone deacetylase based on arylsulfinyl-2,4-hexadienoic acid hydroxyamides. J Med Chem. 2006 Jan 26;49(2):800-5. DM2I95Z RU https://pubmed.ncbi.nlm.nih.gov/16420064 DM81DTC DI DM81DTC DM81DTC DN 6-Benzenesulfonyl-2H-pyridazin-3-one DM81DTC MI TTFBNVI DM81DTC MN Aldose reductase (AKR1B1) DM81DTC MT DTT DM81DTC MA Inhibitor DM81DTC RN A novel series of non-carboxylic acid, non-hydantoin inhibitors of aldose reductase with potent oral activity in diabetic rat models: 6-(5-chloro-3... J Med Chem. 2005 Oct 6;48(20):6326-39. DM81DTC RU https://pubmed.ncbi.nlm.nih.gov/16190759 DMY9IK8 DI DMY9IK8 DMY9IK8 DN 6-benzenesulfonylhexanoic acid hydroxamide DMY9IK8 MI TTBH0VX DMY9IK8 MN Histone deacetylase (HDAC) DMY9IK8 MT DTT DMY9IK8 MA Inhibitor DMY9IK8 RN Aromatic sulfide inhibitors of histone deacetylase based on arylsulfinyl-2,4-hexadienoic acid hydroxyamides. J Med Chem. 2006 Jan 26;49(2):800-5. DMY9IK8 RU https://pubmed.ncbi.nlm.nih.gov/16420064 DMY9IK8 DI DMY9IK8 DMY9IK8 DN 6-benzenesulfonylhexanoic acid hydroxamide DMY9IK8 MI TT6R7JZ DMY9IK8 MN Histone deacetylase 1 (HDAC1) DMY9IK8 MT DTT DMY9IK8 MA Inhibitor DMY9IK8 RN Aromatic sulfide inhibitors of histone deacetylase based on arylsulfinyl-2,4-hexadienoic acid hydroxyamides. J Med Chem. 2006 Jan 26;49(2):800-5. DMY9IK8 RU https://pubmed.ncbi.nlm.nih.gov/16420064 DMY9IK8 DI DMY9IK8 DMY9IK8 DN 6-benzenesulfonylhexanoic acid hydroxamide DMY9IK8 MI TTYHPU6 DMY9IK8 MN Histone deacetylase 10 (HDAC10) DMY9IK8 MT DTT DMY9IK8 MA Inhibitor DMY9IK8 RN Aromatic sulfide inhibitors of histone deacetylase based on arylsulfinyl-2,4-hexadienoic acid hydroxyamides. J Med Chem. 2006 Jan 26;49(2):800-5. DMY9IK8 RU https://pubmed.ncbi.nlm.nih.gov/16420064 DMY9IK8 DI DMY9IK8 DMY9IK8 DN 6-benzenesulfonylhexanoic acid hydroxamide DMY9IK8 MI TTSHTOI DMY9IK8 MN Histone deacetylase 2 (HDAC2) DMY9IK8 MT DTT DMY9IK8 MA Inhibitor DMY9IK8 RN Aromatic sulfide inhibitors of histone deacetylase based on arylsulfinyl-2,4-hexadienoic acid hydroxyamides. J Med Chem. 2006 Jan 26;49(2):800-5. DMY9IK8 RU https://pubmed.ncbi.nlm.nih.gov/16420064 DMY9IK8 DI DMY9IK8 DMY9IK8 DN 6-benzenesulfonylhexanoic acid hydroxamide DMY9IK8 MI TTTQGH8 DMY9IK8 MN Histone deacetylase 4 (HDAC4) DMY9IK8 MT DTT DMY9IK8 MA Inhibitor DMY9IK8 RN Aromatic sulfide inhibitors of histone deacetylase based on arylsulfinyl-2,4-hexadienoic acid hydroxyamides. J Med Chem. 2006 Jan 26;49(2):800-5. DMY9IK8 RU https://pubmed.ncbi.nlm.nih.gov/16420064 DMY9IK8 DI DMY9IK8 DMY9IK8 DN 6-benzenesulfonylhexanoic acid hydroxamide DMY9IK8 MI TT5ZKDI DMY9IK8 MN Histone deacetylase 6 (HDAC6) DMY9IK8 MT DTT DMY9IK8 MA Inhibitor DMY9IK8 RN Aromatic sulfide inhibitors of histone deacetylase based on arylsulfinyl-2,4-hexadienoic acid hydroxyamides. J Med Chem. 2006 Jan 26;49(2):800-5. DMY9IK8 RU https://pubmed.ncbi.nlm.nih.gov/16420064 DMY9IK8 DI DMY9IK8 DMY9IK8 DN 6-benzenesulfonylhexanoic acid hydroxamide DMY9IK8 MI TTT6LFV DMY9IK8 MN Histone deacetylase 8 (HDAC8) DMY9IK8 MT DTT DMY9IK8 MA Inhibitor DMY9IK8 RN Aromatic sulfide inhibitors of histone deacetylase based on arylsulfinyl-2,4-hexadienoic acid hydroxyamides. J Med Chem. 2006 Jan 26;49(2):800-5. DMY9IK8 RU https://pubmed.ncbi.nlm.nih.gov/16420064 DM0CZ1F DI DM0CZ1F DM0CZ1F DN 6-Benzyl-2-cyclohexylsulfanyl-3H-pyrimidin-4-one DM0CZ1F MI TT84ETX DM0CZ1F MN Human immunodeficiency virus Reverse transcriptase (HIV RT) DM0CZ1F MT DTT DM0CZ1F MA Inhibitor DM0CZ1F RN Synthesis and anti-HIV-1 activity of thio analogues of dihydroalkoxybenzyloxopyrimidines. J Med Chem. 1995 Aug 18;38(17):3258-63. DM0CZ1F RU https://pubmed.ncbi.nlm.nih.gov/7650679 DMZRQEF DI DMZRQEF DMZRQEF DN 6-Benzyl-2-cyclopentylsulfanyl-3H-pyrimidin-4-one DMZRQEF MI TT84ETX DMZRQEF MN Human immunodeficiency virus Reverse transcriptase (HIV RT) DMZRQEF MT DTT DMZRQEF MA Inhibitor DMZRQEF RN 5-Alkyl-2-(alkylthio)-6-(2,6-dihalophenylmethyl)-3, 4-dihydropyrimidin-4(3H)-ones: novel potent and selective dihydro-alkoxy-benzyl-oxopyrimidine d... J Med Chem. 1999 Feb 25;42(4):619-27. DMZRQEF RU https://pubmed.ncbi.nlm.nih.gov/10052969 DMI5RNJ DI DMI5RNJ DMI5RNJ DN 6-Benzyl-2-isobutylsulfanyl-3H-pyrimidin-4-one DMI5RNJ MI TT84ETX DMI5RNJ MN Human immunodeficiency virus Reverse transcriptase (HIV RT) DMI5RNJ MT DTT DMI5RNJ MA Inhibitor DMI5RNJ RN Synthesis and anti-HIV-1 activity of thio analogues of dihydroalkoxybenzyloxopyrimidines. J Med Chem. 1995 Aug 18;38(17):3258-63. DMI5RNJ RU https://pubmed.ncbi.nlm.nih.gov/7650679 DM7ANE3 DI DM7ANE3 DM7ANE3 DN 6-Benzyl-2-sec-butylsulfanyl-3H-pyrimidin-4-one DM7ANE3 MI TT84ETX DM7ANE3 MN Human immunodeficiency virus Reverse transcriptase (HIV RT) DM7ANE3 MT DTT DM7ANE3 MA Inhibitor DM7ANE3 RN 5-Alkyl-2-(alkylthio)-6-(2,6-dihalophenylmethyl)-3, 4-dihydropyrimidin-4(3H)-ones: novel potent and selective dihydro-alkoxy-benzyl-oxopyrimidine d... J Med Chem. 1999 Feb 25;42(4):619-27. DM7ANE3 RU https://pubmed.ncbi.nlm.nih.gov/10052969 DMICRFQ DI DMICRFQ DMICRFQ DN 6-benzyl-3-ethoxycarbonyl-4-quinolone DMICRFQ MI TT1MPAY DMICRFQ MN GABA(A) receptor alpha-1 (GABRA1) DMICRFQ MT DTT DMICRFQ MA Inhibitor DMICRFQ RN 4-quinolone derivatives: high-affinity ligands at the benzodiazepine site of brain GABA A receptors. synthesis, pharmacology, and pharmacophore mod... J Med Chem. 2006 Apr 20;49(8):2526-33. DMICRFQ RU https://pubmed.ncbi.nlm.nih.gov/16610795 DMICRFQ DI DMICRFQ DMICRFQ DN 6-benzyl-3-ethoxycarbonyl-4-quinolone DMICRFQ MI TT37EDJ DMICRFQ MN GABA(A) receptor alpha-3 (GABRA3) DMICRFQ MT DTT DMICRFQ MA Inhibitor DMICRFQ RN 4-quinolone derivatives: high-affinity ligands at the benzodiazepine site of brain GABA A receptors. synthesis, pharmacology, and pharmacophore mod... J Med Chem. 2006 Apr 20;49(8):2526-33. DMICRFQ RU https://pubmed.ncbi.nlm.nih.gov/16610795 DMICRFQ DI DMICRFQ DMICRFQ DN 6-benzyl-3-ethoxycarbonyl-4-quinolone DMICRFQ MI TTZA1NY DMICRFQ MN GABA(A) receptor beta-2 (GABRB2) DMICRFQ MT DTT DMICRFQ MA Inhibitor DMICRFQ RN 4-quinolone derivatives: high-affinity ligands at the benzodiazepine site of brain GABA A receptors. synthesis, pharmacology, and pharmacophore mod... J Med Chem. 2006 Apr 20;49(8):2526-33. DMICRFQ RU https://pubmed.ncbi.nlm.nih.gov/16610795 DMICRFQ DI DMICRFQ DMICRFQ DN 6-benzyl-3-ethoxycarbonyl-4-quinolone DMICRFQ MI TT06RH5 DMICRFQ MN GABA(A) receptor gamma-2 (GABRG2) DMICRFQ MT DTT DMICRFQ MA Inhibitor DMICRFQ RN 4-quinolone derivatives: high-affinity ligands at the benzodiazepine site of brain GABA A receptors. synthesis, pharmacology, and pharmacophore mod... J Med Chem. 2006 Apr 20;49(8):2526-33. DMICRFQ RU https://pubmed.ncbi.nlm.nih.gov/16610795 DMICRFQ DI DMICRFQ DMICRFQ DN 6-benzyl-3-ethoxycarbonyl-4-quinolone DMICRFQ MI TTNJYV2 DMICRFQ MN Gamma-aminobutyric acid receptor (GAR) DMICRFQ MT DTT DMICRFQ MA Inhibitor DMICRFQ RN 4-quinolone derivatives: high-affinity ligands at the benzodiazepine site of brain GABA A receptors. synthesis, pharmacology, and pharmacophore mod... J Med Chem. 2006 Apr 20;49(8):2526-33. DMICRFQ RU https://pubmed.ncbi.nlm.nih.gov/16610795 DMXMI5E DI DMXMI5E DMXMI5E DN 6-benzyl-3-propoxycarbonyl-4-quinolone DMXMI5E MI TT1MPAY DMXMI5E MN GABA(A) receptor alpha-1 (GABRA1) DMXMI5E MT DTT DMXMI5E MA Inhibitor DMXMI5E RN 4-quinolone derivatives: high-affinity ligands at the benzodiazepine site of brain GABA A receptors. synthesis, pharmacology, and pharmacophore mod... J Med Chem. 2006 Apr 20;49(8):2526-33. DMXMI5E RU https://pubmed.ncbi.nlm.nih.gov/16610795 DMXMI5E DI DMXMI5E DMXMI5E DN 6-benzyl-3-propoxycarbonyl-4-quinolone DMXMI5E MI TTZA1NY DMXMI5E MN GABA(A) receptor beta-2 (GABRB2) DMXMI5E MT DTT DMXMI5E MA Inhibitor DMXMI5E RN 4-quinolone derivatives: high-affinity ligands at the benzodiazepine site of brain GABA A receptors. synthesis, pharmacology, and pharmacophore mod... J Med Chem. 2006 Apr 20;49(8):2526-33. DMXMI5E RU https://pubmed.ncbi.nlm.nih.gov/16610795 DMXMI5E DI DMXMI5E DMXMI5E DN 6-benzyl-3-propoxycarbonyl-4-quinolone DMXMI5E MI TT06RH5 DMXMI5E MN GABA(A) receptor gamma-2 (GABRG2) DMXMI5E MT DTT DMXMI5E MA Inhibitor DMXMI5E RN 4-quinolone derivatives: high-affinity ligands at the benzodiazepine site of brain GABA A receptors. synthesis, pharmacology, and pharmacophore mod... J Med Chem. 2006 Apr 20;49(8):2526-33. DMXMI5E RU https://pubmed.ncbi.nlm.nih.gov/16610795 DMXMI5E DI DMXMI5E DMXMI5E DN 6-benzyl-3-propoxycarbonyl-4-quinolone DMXMI5E MI TTNJYV2 DMXMI5E MN Gamma-aminobutyric acid receptor (GAR) DMXMI5E MT DTT DMXMI5E MA Inhibitor DMXMI5E RN 4-quinolone derivatives: high-affinity ligands at the benzodiazepine site of brain GABA A receptors. synthesis, pharmacology, and pharmacophore mod... J Med Chem. 2006 Apr 20;49(8):2526-33. DMXMI5E RU https://pubmed.ncbi.nlm.nih.gov/16610795 DM7HNPJ DI DM7HNPJ DM7HNPJ DN 6-benzyl-3-propylaminocarbonyl-4-quinolone DM7HNPJ MI TT1MPAY DM7HNPJ MN GABA(A) receptor alpha-1 (GABRA1) DM7HNPJ MT DTT DM7HNPJ MA Inhibitor DM7HNPJ RN 4-quinolone derivatives: high-affinity ligands at the benzodiazepine site of brain GABA A receptors. synthesis, pharmacology, and pharmacophore mod... J Med Chem. 2006 Apr 20;49(8):2526-33. DM7HNPJ RU https://pubmed.ncbi.nlm.nih.gov/16610795 DM7HNPJ DI DM7HNPJ DM7HNPJ DN 6-benzyl-3-propylaminocarbonyl-4-quinolone DM7HNPJ MI TTZA1NY DM7HNPJ MN GABA(A) receptor beta-2 (GABRB2) DM7HNPJ MT DTT DM7HNPJ MA Inhibitor DM7HNPJ RN 4-quinolone derivatives: high-affinity ligands at the benzodiazepine site of brain GABA A receptors. synthesis, pharmacology, and pharmacophore mod... J Med Chem. 2006 Apr 20;49(8):2526-33. DM7HNPJ RU https://pubmed.ncbi.nlm.nih.gov/16610795 DM7HNPJ DI DM7HNPJ DM7HNPJ DN 6-benzyl-3-propylaminocarbonyl-4-quinolone DM7HNPJ MI TT06RH5 DM7HNPJ MN GABA(A) receptor gamma-2 (GABRG2) DM7HNPJ MT DTT DM7HNPJ MA Inhibitor DM7HNPJ RN 4-quinolone derivatives: high-affinity ligands at the benzodiazepine site of brain GABA A receptors. synthesis, pharmacology, and pharmacophore mod... J Med Chem. 2006 Apr 20;49(8):2526-33. DM7HNPJ RU https://pubmed.ncbi.nlm.nih.gov/16610795 DM7HNPJ DI DM7HNPJ DM7HNPJ DN 6-benzyl-3-propylaminocarbonyl-4-quinolone DM7HNPJ MI TTNJYV2 DM7HNPJ MN Gamma-aminobutyric acid receptor (GAR) DM7HNPJ MT DTT DM7HNPJ MA Inhibitor DM7HNPJ RN 4-quinolone derivatives: high-affinity ligands at the benzodiazepine site of brain GABA A receptors. synthesis, pharmacology, and pharmacophore mod... J Med Chem. 2006 Apr 20;49(8):2526-33. DM7HNPJ RU https://pubmed.ncbi.nlm.nih.gov/16610795 DM8FUZL DI DM8FUZL DM8FUZL DN 6-Benzylamino-1H-pyrimidine-2,4-dione DM8FUZL MI TT2GPK3 DM8FUZL MN DNA topoisomerase (TOP) DM8FUZL MT DTT DM8FUZL MA Inhibitor DM8FUZL RN Inhibitors of Bacillus subtilis DNA polymerase III. Influence of modifications in the pyrimidine ring of anilino- and (benzylamino)pyrimidines. J Med Chem. 1986 May;29(5):676-81. DM8FUZL RU https://pubmed.ncbi.nlm.nih.gov/3084785 DMGJYWF DI DMGJYWF DMGJYWF DN 6-Benzylamino-5-bromo-1H-pyrimidine-2,4-dione DMGJYWF MI TT2GPK3 DMGJYWF MN DNA topoisomerase (TOP) DMGJYWF MT DTT DMGJYWF MA Inhibitor DMGJYWF RN Inhibitors of Bacillus subtilis DNA polymerase III. Influence of modifications in the pyrimidine ring of anilino- and (benzylamino)pyrimidines. J Med Chem. 1986 May;29(5):676-81. DMGJYWF RU https://pubmed.ncbi.nlm.nih.gov/3084785 DM8FTNC DI DM8FTNC DM8FTNC DN 6-Benzylamino-5-iodo-1H-pyrimidine-2,4-dione DM8FTNC MI TT2GPK3 DM8FTNC MN DNA topoisomerase (TOP) DM8FTNC MT DTT DM8FTNC MA Inhibitor DM8FTNC RN Inhibitors of Bacillus subtilis DNA polymerase III. Influence of modifications in the pyrimidine ring of anilino- and (benzylamino)pyrimidines. J Med Chem. 1986 May;29(5):676-81. DM8FTNC RU https://pubmed.ncbi.nlm.nih.gov/3084785 DMK8XIO DI DMK8XIO DMK8XIO DN 6-Benzyloxy-5-nitro-pyrimidine-2,4-diamine DMK8XIO MI TTJ8DV7 DMK8XIO MN O-6-methylguanine-DNA-alkyltransferase (MGMT) DMK8XIO MT DTT DMK8XIO MA Inhibitor DMK8XIO RN Inhibition of human O6-alkylguanine-DNA alkyltransferase and potentiation of the cytotoxicity of chloroethylnitrosourea by 4(6)-(benzyloxy)-2,6(4)-... J Med Chem. 1998 Feb 12;41(4):503-8. DMK8XIO RU https://pubmed.ncbi.nlm.nih.gov/9484500 DMUFSE2 DI DMUFSE2 DMUFSE2 DN 6-Benzyloxy-5-nitroso-pyrimidine-2,4-diamine DMUFSE2 MI TTJ8DV7 DMUFSE2 MN O-6-methylguanine-DNA-alkyltransferase (MGMT) DMUFSE2 MT DTT DMUFSE2 MA Inhibitor DMUFSE2 RN Inhibition of human O6-alkylguanine-DNA alkyltransferase and potentiation of the cytotoxicity of chloroethylnitrosourea by 4(6)-(benzyloxy)-2,6(4)-... J Med Chem. 1998 Feb 12;41(4):503-8. DMUFSE2 RU https://pubmed.ncbi.nlm.nih.gov/9484500 DMFI7A8 DI DMFI7A8 DMFI7A8 DN 6-Benzyloxy-9H-purin-2-ylamine DMFI7A8 MI DEJGDUW DMFI7A8 MN Cytochrome P450 1A2 (CYP1A2) DMFI7A8 MT DME DMFI7A8 MA Metabolism DMFI7A8 RN Human liver oxidative metabolism of O6-benzylguanine. Biochem Pharmacol. 1995 Oct 26;50(9):1385-9. DMFI7A8 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=7503788 DMFI7A8 DI DMFI7A8 DMFI7A8 DN 6-Benzyloxy-9H-purin-2-ylamine DMFI7A8 MI DE4LYSA DMFI7A8 MN Cytochrome P450 3A4 (CYP3A4) DMFI7A8 MT DME DMFI7A8 MA Metabolism DMFI7A8 RN Human liver oxidative metabolism of O6-benzylguanine. Biochem Pharmacol. 1995 Oct 26;50(9):1385-9. DMFI7A8 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=7503788 DMFI7A8 DI DMFI7A8 DMFI7A8 DN 6-Benzyloxy-9H-purin-2-ylamine DMFI7A8 MI TTJ8DV7 DMFI7A8 MN O-6-methylguanine-DNA-alkyltransferase (MGMT) DMFI7A8 MT DTT DMFI7A8 MA Inhibitor DMFI7A8 RN Inhibition of human O6-alkylguanine-DNA alkyltransferase and potentiation of the cytotoxicity of chloroethylnitrosourea by 4(6)-(benzyloxy)-2,6(4)-... J Med Chem. 1998 Feb 12;41(4):503-8. DMFI7A8 RU https://pubmed.ncbi.nlm.nih.gov/9484500 DMARP3M DI DMARP3M DMARP3M DN 6-Benzyloxybenzo[b]thiophene-2-carboxamidine DMARP3M MI TTFEZ5Q DMARP3M MN Coagulation factor IX (F9) DMARP3M MT DTT DMARP3M MA Inhibitor DMARP3M RN Studies of benzothiophene template as potent factor IXa (FIXa) inhibitors in thrombosis. J Med Chem. 2010 Feb 25;53(4):1465-72. DMARP3M RU https://pubmed.ncbi.nlm.nih.gov/20121198 DMI7FNZ DI DMI7FNZ DMI7FNZ DN 6-Benzylsulfanyl-9H-purine DMI7FNZ MI TTAN5W2 DMI7FNZ MN Raf messenger RNA (Raf mRNA) DMI7FNZ MT DTT DMI7FNZ MA Inhibitor DMI7FNZ RN Synthesis and biological testing of purine derivatives as potential ATP-competitive kinase inhibitors. J Med Chem. 2005 Feb 10;48(3):710-22. DMI7FNZ RU https://pubmed.ncbi.nlm.nih.gov/15689155 DMI7FNZ DI DMI7FNZ DMI7FNZ DN 6-Benzylsulfanyl-9H-purine DMI7FNZ MI TTQBR95 DMI7FNZ MN Stress-activated protein kinase 2a (p38 alpha) DMI7FNZ MT DTT DMI7FNZ MA Inhibitor DMI7FNZ RN Synthesis and biological testing of purine derivatives as potential ATP-competitive kinase inhibitors. J Med Chem. 2005 Feb 10;48(3):710-22. DMI7FNZ RU https://pubmed.ncbi.nlm.nih.gov/15689155 DMNXGZP DI DMNXGZP DMNXGZP DN 6-Benzylthioinosine DMNXGZP MI TTL732K DMNXGZP MN Adenosine kinase (ADK) DMNXGZP MT DTT DMNXGZP MA Inhibitor DMNXGZP RN Structure-activity relationships of carbocyclic 6-benzylthioinosine analogues as subversive substrates of Toxoplasma gondii adenosine kinase. Bioorg Med Chem. 2010 May 15;18(10):3403-12. DMNXGZP RU https://pubmed.ncbi.nlm.nih.gov/20456959 DMZ8PBE DI DMZ8PBE DMZ8PBE DN 6beta-naltrexol HCl DMZ8PBE MI TT27RFC DMZ8PBE MN Opioid receptor delta (OPRD1) DMZ8PBE MT DTT DMZ8PBE MA Inhibitor DMZ8PBE RN Design, synthesis, and characterization of 6beta-naltrexol analogs, and their selectivity for in vitro opioid receptor subtypes. Bioorg Med Chem Lett. 2009 May 15;19(10):2811-4. DMZ8PBE RU https://pubmed.ncbi.nlm.nih.gov/19364645 DMZ8PBE DI DMZ8PBE DMZ8PBE DN 6beta-naltrexol HCl DMZ8PBE MI TTQW87Y DMZ8PBE MN Opioid receptor kappa (OPRK1) DMZ8PBE MT DTT DMZ8PBE MA Inhibitor DMZ8PBE RN Design, synthesis, and characterization of 6beta-naltrexol analogs, and their selectivity for in vitro opioid receptor subtypes. Bioorg Med Chem Lett. 2009 May 15;19(10):2811-4. DMZ8PBE RU https://pubmed.ncbi.nlm.nih.gov/19364645 DMZ8PBE DI DMZ8PBE DMZ8PBE DN 6beta-naltrexol HCl DMZ8PBE MI TTKWM86 DMZ8PBE MN Opioid receptor mu (MOP) DMZ8PBE MT DTT DMZ8PBE MA Inhibitor DMZ8PBE RN Design, synthesis, and characterization of 6beta-naltrexol analogs, and their selectivity for in vitro opioid receptor subtypes. Bioorg Med Chem Lett. 2009 May 15;19(10):2811-4. DMZ8PBE RU https://pubmed.ncbi.nlm.nih.gov/19364645 DMZPY69 DI DMZPY69 DMZPY69 DN 6-biphenyl-2-yl-2-morpholin-4-yl-chromen-4-one DMZPY69 MI TTK3PY9 DMZPY69 MN DNA-dependent protein kinase catalytic (PRKDC) DMZPY69 MT DTT DMZPY69 MA Inhibitor DMZPY69 RN Discovery of potent chromen-4-one inhibitors of the DNA-dependent protein kinase (DNA-PK) using a small-molecule library approach. J Med Chem. 2005 Dec 1;48(24):7829-46. DMZPY69 RU https://pubmed.ncbi.nlm.nih.gov/16302822 DMU9WG0 DI DMU9WG0 DMU9WG0 DN 6-bromo-1H-indazole DMU9WG0 MI TTZUFI5 DMU9WG0 MN Nitric-oxide synthase brain (NOS1) DMU9WG0 MT DTT DMU9WG0 MA Inhibitor DMU9WG0 RN 4-substituted indazoles as new inhibitors of neuronal nitric oxide synthase. Bioorg Med Chem Lett. 2007 Jun 1;17(11):3177-80. DMU9WG0 RU https://pubmed.ncbi.nlm.nih.gov/17395463 DMM9GOR DI DMM9GOR DMM9GOR DN 6-bromo-1-methyl-3-(pyridin-4-yl)-1H-indole DMM9GOR MI TTTB4UP DMM9GOR MN Inosine-5'-monophosphate dehydrogenase 2 (IMPDH2) DMM9GOR MT DTT DMM9GOR MA Inhibitor DMM9GOR RN Low molecular weight indole fragments as IMPDH inhibitors. Bioorg Med Chem Lett. 2006 May 1;16(9):2535-8. DMM9GOR RU https://pubmed.ncbi.nlm.nih.gov/16483769 DM7U58O DI DM7U58O DM7U58O DN 6-Bromo-2-(2-nitro-phenyl)-chromen-4-one DM7U58O MI TT1MPAY DM7U58O MN GABA(A) receptor alpha-1 (GABRA1) DM7U58O MT DTT DM7U58O MA Inhibitor DM7U58O RN 6-Bromo-3 nitroflavone, a new high affinity benzodiazepine receptor agonist recognizes two populations of cerebral cortical binding sites, Bioorg. Med. Chem. Lett. 7(3):373-378 (1997). DM7U58O RU http://www.sciencedirect.com/science/article/pii/S0960894X97000206 DM7U58O DI DM7U58O DM7U58O DN 6-Bromo-2-(2-nitro-phenyl)-chromen-4-one DM7U58O MI TTNJYV2 DM7U58O MN Gamma-aminobutyric acid receptor (GAR) DM7U58O MT DTT DM7U58O MA Inhibitor DM7U58O RN 6-Bromo-3 nitroflavone, a new high affinity benzodiazepine receptor agonist recognizes two populations of cerebral cortical binding sites, Bioorg. Med. Chem. Lett. 7(3):373-378 (1997). DM7U58O RU http://www.sciencedirect.com/science/article/pii/S0960894X97000206 DMTJRF3 DI DMTJRF3 DMTJRF3 DN 6-Bromo-2-(3-bromo-phenyl)-chromen-4-one DMTJRF3 MI TT1MPAY DMTJRF3 MN GABA(A) receptor alpha-1 (GABRA1) DMTJRF3 MT DTT DMTJRF3 MA Inhibitor DMTJRF3 RN Synthesis of halogenated/nitrated flavone derivatives and evaluation of their affinity for the central benzodiazepine receptor, Bioorg. Med. Chem. Lett. 7(15):2003-2008 (1997). DMTJRF3 RU http://www.sciencedirect.com/science/article/pii/S0960894X97003430 DMTJRF3 DI DMTJRF3 DMTJRF3 DN 6-Bromo-2-(3-bromo-phenyl)-chromen-4-one DMTJRF3 MI TTNJYV2 DMTJRF3 MN Gamma-aminobutyric acid receptor (GAR) DMTJRF3 MT DTT DMTJRF3 MA Inhibitor DMTJRF3 RN Synthesis of halogenated/nitrated flavone derivatives and evaluation of their affinity for the central benzodiazepine receptor, Bioorg. Med. Chem. Lett. 7(15):2003-2008 (1997). DMTJRF3 RU http://www.sciencedirect.com/science/article/pii/S0960894X97003430 DMP8ZVS DI DMP8ZVS DMP8ZVS DN 6-Bromo-2-(3-nitro-phenyl)-chromen-4-one DMP8ZVS MI TT1MPAY DMP8ZVS MN GABA(A) receptor alpha-1 (GABRA1) DMP8ZVS MT DTT DMP8ZVS MA Inhibitor DMP8ZVS RN 6-Bromo-3 nitroflavone, a new high affinity benzodiazepine receptor agonist recognizes two populations of cerebral cortical binding sites, Bioorg. Med. Chem. Lett. 7(3):373-378 (1997). DMP8ZVS RU http://www.sciencedirect.com/science/article/pii/S0960894X97000206 DMP8ZVS DI DMP8ZVS DMP8ZVS DN 6-Bromo-2-(3-nitro-phenyl)-chromen-4-one DMP8ZVS MI TTNJYV2 DMP8ZVS MN Gamma-aminobutyric acid receptor (GAR) DMP8ZVS MT DTT DMP8ZVS MA Inhibitor DMP8ZVS RN 6-Bromo-3 nitroflavone, a new high affinity benzodiazepine receptor agonist recognizes two populations of cerebral cortical binding sites, Bioorg. Med. Chem. Lett. 7(3):373-378 (1997). DMP8ZVS RU http://www.sciencedirect.com/science/article/pii/S0960894X97000206 DMCX3TM DI DMCX3TM DMCX3TM DN 6-Bromo-2-(4-nitro-phenyl)-chromen-4-one DMCX3TM MI TT1MPAY DMCX3TM MN GABA(A) receptor alpha-1 (GABRA1) DMCX3TM MT DTT DMCX3TM MA Inhibitor DMCX3TM RN 6-Bromo-3 nitroflavone, a new high affinity benzodiazepine receptor agonist recognizes two populations of cerebral cortical binding sites, Bioorg. Med. Chem. Lett. 7(3):373-378 (1997). DMCX3TM RU http://www.sciencedirect.com/science/article/pii/S0960894X97000206 DMCX3TM DI DMCX3TM DMCX3TM DN 6-Bromo-2-(4-nitro-phenyl)-chromen-4-one DMCX3TM MI TTNJYV2 DMCX3TM MN Gamma-aminobutyric acid receptor (GAR) DMCX3TM MT DTT DMCX3TM MA Inhibitor DMCX3TM RN 6-Bromo-3 nitroflavone, a new high affinity benzodiazepine receptor agonist recognizes two populations of cerebral cortical binding sites, Bioorg. Med. Chem. Lett. 7(3):373-378 (1997). DMCX3TM RU http://www.sciencedirect.com/science/article/pii/S0960894X97000206 DMXQ8K1 DI DMXQ8K1 DMXQ8K1 DN 6-Bromo-2,3,4,9-tetrahydro-1H-beta-carboline DMXQ8K1 MI TT3WG5C DMXQ8K1 MN Monoamine oxidase type A (MAO-A) DMXQ8K1 MT DTT DMXQ8K1 MA Inhibitor DMXQ8K1 RN Binding of beta-carbolines at imidazoline I2 receptors: a structure-affinity investigation. Bioorg Med Chem Lett. 2004 Feb 23;14(4):999-1002. DMXQ8K1 RU https://pubmed.ncbi.nlm.nih.gov/15013009 DMXQ8K1 DI DMXQ8K1 DMXQ8K1 DN 6-Bromo-2,3,4,9-tetrahydro-1H-beta-carboline DMXQ8K1 MI TTGP7BY DMXQ8K1 MN Monoamine oxidase type B (MAO-B) DMXQ8K1 MT DTT DMXQ8K1 MA Inhibitor DMXQ8K1 RN Binding of beta-carbolines at imidazoline I2 receptors: a structure-affinity investigation. Bioorg Med Chem Lett. 2004 Feb 23;14(4):999-1002. DMXQ8K1 RU https://pubmed.ncbi.nlm.nih.gov/15013009 DM39VT6 DI DM39VT6 DM39VT6 DN 6-bromo-2'-de-N-methylaplysinopsin DM39VT6 MI TTWJBZ5 DM39VT6 MN 5-HT 2C receptor (HTR2C) DM39VT6 MT DTT DM39VT6 MA Inhibitor DM39VT6 RN New antiinfective and human 5-HT2 receptor binding natural and semisynthetic compounds from the Jamaican sponge Smenospongia aurea. J Nat Prod. 2002 Apr;65(4):476-80. DM39VT6 RU https://pubmed.ncbi.nlm.nih.gov/11975483 DMMCNQI DI DMMCNQI DMMCNQI DN 6-Bromo-2-phenyl-chromen-4-one DMMCNQI MI TT1MPAY DMMCNQI MN GABA(A) receptor alpha-1 (GABRA1) DMMCNQI MT DTT DMMCNQI MA Inhibitor DMMCNQI RN Synthesis of halogenated/nitrated flavone derivatives and evaluation of their affinity for the central benzodiazepine receptor, Bioorg. Med. Chem. Lett. 7(15):2003-2008 (1997). DMMCNQI RU http://www.sciencedirect.com/science/article/pii/S0960894X97003430 DMMCNQI DI DMMCNQI DMMCNQI DN 6-Bromo-2-phenyl-chromen-4-one DMMCNQI MI TTNJYV2 DMMCNQI MN Gamma-aminobutyric acid receptor (GAR) DMMCNQI MT DTT DMMCNQI MA Inhibitor DMMCNQI RN Synthesis of halogenated/nitrated flavone derivatives and evaluation of their affinity for the central benzodiazepine receptor, Bioorg. Med. Chem. Lett. 7(15):2003-2008 (1997). DMMCNQI RU http://www.sciencedirect.com/science/article/pii/S0960894X97003430 DMLT01H DI DMLT01H DMLT01H DN 6-Bromo-2-piperazin-1-yl-quinoline DMLT01H MI TT3ROYC DMLT01H MN Serotonin transporter (SERT) DMLT01H MT DTT DMLT01H MA Inhibitor DMLT01H RN Syntheses and binding affinities of 6-nitroquipazine analogues for serotonin transporter. Part 1. Bioorg Med Chem Lett. 2000 Jul 17;10(14):1559-62. DMLT01H RU https://pubmed.ncbi.nlm.nih.gov/10915050 DMVWX62 DI DMVWX62 DMVWX62 DN 6-bromo-3-(pyridin-4-yl)-1H-indole DMVWX62 MI TTTB4UP DMVWX62 MN Inosine-5'-monophosphate dehydrogenase 2 (IMPDH2) DMVWX62 MT DTT DMVWX62 MA Inhibitor DMVWX62 RN Low molecular weight indole fragments as IMPDH inhibitors. Bioorg Med Chem Lett. 2006 May 1;16(9):2535-8. DMVWX62 RU https://pubmed.ncbi.nlm.nih.gov/16483769 DM4HRIX DI DM4HRIX DM4HRIX DN 6-bromo-3-ethoxycarbonyl-2-methyl-4-quinolone DM4HRIX MI TT1MPAY DM4HRIX MN GABA(A) receptor alpha-1 (GABRA1) DM4HRIX MT DTT DM4HRIX MA Inhibitor DM4HRIX RN 4-quinolone derivatives: high-affinity ligands at the benzodiazepine site of brain GABA A receptors. synthesis, pharmacology, and pharmacophore mod... J Med Chem. 2006 Apr 20;49(8):2526-33. DM4HRIX RU https://pubmed.ncbi.nlm.nih.gov/16610795 DM4HRIX DI DM4HRIX DM4HRIX DN 6-bromo-3-ethoxycarbonyl-2-methyl-4-quinolone DM4HRIX MI TTZA1NY DM4HRIX MN GABA(A) receptor beta-2 (GABRB2) DM4HRIX MT DTT DM4HRIX MA Inhibitor DM4HRIX RN 4-quinolone derivatives: high-affinity ligands at the benzodiazepine site of brain GABA A receptors. synthesis, pharmacology, and pharmacophore mod... J Med Chem. 2006 Apr 20;49(8):2526-33. DM4HRIX RU https://pubmed.ncbi.nlm.nih.gov/16610795 DM4HRIX DI DM4HRIX DM4HRIX DN 6-bromo-3-ethoxycarbonyl-2-methyl-4-quinolone DM4HRIX MI TT06RH5 DM4HRIX MN GABA(A) receptor gamma-2 (GABRG2) DM4HRIX MT DTT DM4HRIX MA Inhibitor DM4HRIX RN 4-quinolone derivatives: high-affinity ligands at the benzodiazepine site of brain GABA A receptors. synthesis, pharmacology, and pharmacophore mod... J Med Chem. 2006 Apr 20;49(8):2526-33. DM4HRIX RU https://pubmed.ncbi.nlm.nih.gov/16610795 DM4HRIX DI DM4HRIX DM4HRIX DN 6-bromo-3-ethoxycarbonyl-2-methyl-4-quinolone DM4HRIX MI TTNJYV2 DM4HRIX MN Gamma-aminobutyric acid receptor (GAR) DM4HRIX MT DTT DM4HRIX MA Inhibitor DM4HRIX RN 4-quinolone derivatives: high-affinity ligands at the benzodiazepine site of brain GABA A receptors. synthesis, pharmacology, and pharmacophore mod... J Med Chem. 2006 Apr 20;49(8):2526-33. DM4HRIX RU https://pubmed.ncbi.nlm.nih.gov/16610795 DM0MQHP DI DM0MQHP DM0MQHP DN 6-bromo-3-ethoxycarbonyl-4-quinolone DM0MQHP MI TT1MPAY DM0MQHP MN GABA(A) receptor alpha-1 (GABRA1) DM0MQHP MT DTT DM0MQHP MA Inhibitor DM0MQHP RN 4-quinolone derivatives: high-affinity ligands at the benzodiazepine site of brain GABA A receptors. synthesis, pharmacology, and pharmacophore mod... J Med Chem. 2006 Apr 20;49(8):2526-33. DM0MQHP RU https://pubmed.ncbi.nlm.nih.gov/16610795 DM0MQHP DI DM0MQHP DM0MQHP DN 6-bromo-3-ethoxycarbonyl-4-quinolone DM0MQHP MI TT37EDJ DM0MQHP MN GABA(A) receptor alpha-3 (GABRA3) DM0MQHP MT DTT DM0MQHP MA Inhibitor DM0MQHP RN 4-quinolone derivatives: high-affinity ligands at the benzodiazepine site of brain GABA A receptors. synthesis, pharmacology, and pharmacophore mod... J Med Chem. 2006 Apr 20;49(8):2526-33. DM0MQHP RU https://pubmed.ncbi.nlm.nih.gov/16610795 DM0MQHP DI DM0MQHP DM0MQHP DN 6-bromo-3-ethoxycarbonyl-4-quinolone DM0MQHP MI TTZA1NY DM0MQHP MN GABA(A) receptor beta-2 (GABRB2) DM0MQHP MT DTT DM0MQHP MA Inhibitor DM0MQHP RN 4-quinolone derivatives: high-affinity ligands at the benzodiazepine site of brain GABA A receptors. synthesis, pharmacology, and pharmacophore mod... J Med Chem. 2006 Apr 20;49(8):2526-33. DM0MQHP RU https://pubmed.ncbi.nlm.nih.gov/16610795 DM0MQHP DI DM0MQHP DM0MQHP DN 6-bromo-3-ethoxycarbonyl-4-quinolone DM0MQHP MI TT06RH5 DM0MQHP MN GABA(A) receptor gamma-2 (GABRG2) DM0MQHP MT DTT DM0MQHP MA Inhibitor DM0MQHP RN 4-quinolone derivatives: high-affinity ligands at the benzodiazepine site of brain GABA A receptors. synthesis, pharmacology, and pharmacophore mod... J Med Chem. 2006 Apr 20;49(8):2526-33. DM0MQHP RU https://pubmed.ncbi.nlm.nih.gov/16610795 DM0MQHP DI DM0MQHP DM0MQHP DN 6-bromo-3-ethoxycarbonyl-4-quinolone DM0MQHP MI TTNJYV2 DM0MQHP MN Gamma-aminobutyric acid receptor (GAR) DM0MQHP MT DTT DM0MQHP MA Inhibitor DM0MQHP RN 4-quinolone derivatives: high-affinity ligands at the benzodiazepine site of brain GABA A receptors. synthesis, pharmacology, and pharmacophore mod... J Med Chem. 2006 Apr 20;49(8):2526-33. DM0MQHP RU https://pubmed.ncbi.nlm.nih.gov/16610795 DM64KOZ DI DM64KOZ DM64KOZ DN 6-Bromo-4,9-dihydro-3H-beta-carboline DM64KOZ MI TT3WG5C DM64KOZ MN Monoamine oxidase type A (MAO-A) DM64KOZ MT DTT DM64KOZ MA Inhibitor DM64KOZ RN Binding of beta-carbolines at imidazoline I2 receptors: a structure-affinity investigation. Bioorg Med Chem Lett. 2004 Feb 23;14(4):999-1002. DM64KOZ RU https://pubmed.ncbi.nlm.nih.gov/15013009 DM64KOZ DI DM64KOZ DM64KOZ DN 6-Bromo-4,9-dihydro-3H-beta-carboline DM64KOZ MI TTGP7BY DM64KOZ MN Monoamine oxidase type B (MAO-B) DM64KOZ MT DTT DM64KOZ MA Inhibitor DM64KOZ RN Binding of beta-carbolines at imidazoline I2 receptors: a structure-affinity investigation. Bioorg Med Chem Lett. 2004 Feb 23;14(4):999-1002. DM64KOZ RU https://pubmed.ncbi.nlm.nih.gov/15013009 DMFZ2PI DI DMFZ2PI DMFZ2PI DN 6-bromo-5-methyl-1H-indole-2,3-dione DMFZ2PI MI TTMF541 DMFZ2PI MN Liver carboxylesterase (CES1) DMFZ2PI MT DTT DMFZ2PI MA Inhibitor DMFZ2PI RN Selective inhibition of carboxylesterases by isatins, indole-2,3-diones. J Med Chem. 2007 Apr 19;50(8):1876-85. DMFZ2PI RU https://pubmed.ncbi.nlm.nih.gov/17378546 DM8A1ZU DI DM8A1ZU DM8A1ZU DN 6-bromo-5-phenylpyrimidine-2,4(1H,3H)-dione DM8A1ZU MI TTO0IB8 DM8A1ZU MN Thymidine phosphorylase (TYMP) DM8A1ZU MT DTT DM8A1ZU MA Inhibitor DM8A1ZU RN Discovery of 5-substituted-6-chlorouracils as efficient inhibitors of human thymidine phosphorylase. J Med Chem. 2007 Nov 29;50(24):6016-23. DM8A1ZU RU https://pubmed.ncbi.nlm.nih.gov/17963370 DMZJ6M8 DI DMZJ6M8 DMZJ6M8 DN 6-bromo-8-(piperazin-1-yl)imidazo[1,2-a]pyrazine DMZJ6M8 MI TTWJBZ5 DMZJ6M8 MN 5-HT 2C receptor (HTR2C) DMZJ6M8 MT DTT DMZJ6M8 MA Inhibitor DMZJ6M8 RN Design and synthesis of orally-active and selective azaindane 5HT2c agonist for the treatment of obesity. Bioorg Med Chem Lett. 2010 Jan 1;20(1):266-71. DMZJ6M8 RU https://pubmed.ncbi.nlm.nih.gov/19914063 DMQGB70 DI DMQGB70 DMQGB70 DN 6-bromoaplysinopsin DMQGB70 MI TTJQOD7 DMQGB70 MN 5-HT 2A receptor (HTR2A) DMQGB70 MT DTT DMQGB70 MA Inhibitor DMQGB70 RN New antiinfective and human 5-HT2 receptor binding natural and semisynthetic compounds from the Jamaican sponge Smenospongia aurea. J Nat Prod. 2002 Apr;65(4):476-80. DMQGB70 RU https://pubmed.ncbi.nlm.nih.gov/11975483 DMQGB70 DI DMQGB70 DMQGB70 DN 6-bromoaplysinopsin DMQGB70 MI TTWJBZ5 DMQGB70 MN 5-HT 2C receptor (HTR2C) DMQGB70 MT DTT DMQGB70 MA Inhibitor DMQGB70 RN New antiinfective and human 5-HT2 receptor binding natural and semisynthetic compounds from the Jamaican sponge Smenospongia aurea. J Nat Prod. 2002 Apr;65(4):476-80. DMQGB70 RU https://pubmed.ncbi.nlm.nih.gov/11975483 DM12WYV DI DM12WYV DM12WYV DN 6-bromoindirubin-3-oxime DM12WYV MI TT9RTBL DM12WYV MN Aurora B messenger RNA (AURKB mRNA) DM12WYV MT DTT DM12WYV MA Inhibitor DM12WYV RN An integrated computational approach to the phenomenon of potent and selective inhibition of aurora kinases B and C by a series of 7-substituted in... J Med Chem. 2007 Aug 23;50(17):4027-37. DM12WYV RU https://pubmed.ncbi.nlm.nih.gov/17665890 DM12WYV DI DM12WYV DM12WYV DN 6-bromoindirubin-3-oxime DM12WYV MI TTPS3C0 DM12WYV MN Aurora kinase A (AURKA) DM12WYV MT DTT DM12WYV MA Inhibitor DM12WYV RN An integrated computational approach to the phenomenon of potent and selective inhibition of aurora kinases B and C by a series of 7-substituted in... J Med Chem. 2007 Aug 23;50(17):4027-37. DM12WYV RU https://pubmed.ncbi.nlm.nih.gov/17665890 DM12WYV DI DM12WYV DM12WYV DN 6-bromoindirubin-3-oxime DM12WYV MI TTLYXIT DM12WYV MN Aurora kinase C (AURKC) DM12WYV MT DTT DM12WYV MA Inhibitor DM12WYV RN An integrated computational approach to the phenomenon of potent and selective inhibition of aurora kinases B and C by a series of 7-substituted in... J Med Chem. 2007 Aug 23;50(17):4027-37. DM12WYV RU https://pubmed.ncbi.nlm.nih.gov/17665890 DM12WYV DI DM12WYV DM12WYV DN 6-bromoindirubin-3-oxime DM12WYV MI TTRZQE3 DM12WYV MN Glycogen synthase kinase-3 alpha (GSK-3A) DM12WYV MT DTT DM12WYV MA Inhibitor DM12WYV RN Stable generation of serum- and feeder-free embryonic stem cell-derived mice with full germline-competency by using a GSK3 specific inhibitor. Genesis. 2009 Jun;47(6):414-22. DM12WYV RU https://pubmed.ncbi.nlm.nih.gov/19391115 DMP9O7G DI DMP9O7G DMP9O7G DN 6-bromo-N-(3-bromophenyl)quinazolin-4-amine DMP9O7G MI TTHS256 DMP9O7G MN Metabotropic glutamate receptor 5 (mGluR5) DMP9O7G MT DTT DMP9O7G MA Inhibitor DMP9O7G RN Discovery and SAR of 6-substituted-4-anilinoquinazolines as non-competitive antagonists of mGlu5. Bioorg Med Chem Lett. 2009 Dec 1;19(23):6623-6. DMP9O7G RU https://pubmed.ncbi.nlm.nih.gov/19854049 DM0A3DB DI DM0A3DB DM0A3DB DN 6-bromo-N-(3-chlorophenyl)quinazolin-4-amine DM0A3DB MI TTVBPDM DM0A3DB MN Metabotropic glutamate receptor 1 (mGluR1) DM0A3DB MT DTT DM0A3DB MA Inhibitor DM0A3DB RN Discovery and SAR of 6-substituted-4-anilinoquinazolines as non-competitive antagonists of mGlu5. Bioorg Med Chem Lett. 2009 Dec 1;19(23):6623-6. DM0A3DB RU https://pubmed.ncbi.nlm.nih.gov/19854049 DM0A3DB DI DM0A3DB DM0A3DB DN 6-bromo-N-(3-chlorophenyl)quinazolin-4-amine DM0A3DB MI TTHS256 DM0A3DB MN Metabotropic glutamate receptor 5 (mGluR5) DM0A3DB MT DTT DM0A3DB MA Inhibitor DM0A3DB RN Discovery and SAR of 6-substituted-4-anilinoquinazolines as non-competitive antagonists of mGlu5. Bioorg Med Chem Lett. 2009 Dec 1;19(23):6623-6. DM0A3DB RU https://pubmed.ncbi.nlm.nih.gov/19854049 DM2IP5F DI DM2IP5F DM2IP5F DN 6-bromo-N-(3-fluorophenyl)quinazolin-4-amine DM2IP5F MI TTHS256 DM2IP5F MN Metabotropic glutamate receptor 5 (mGluR5) DM2IP5F MT DTT DM2IP5F MA Inhibitor DM2IP5F RN Discovery and SAR of 6-substituted-4-anilinoquinazolines as non-competitive antagonists of mGlu5. Bioorg Med Chem Lett. 2009 Dec 1;19(23):6623-6. DM2IP5F RU https://pubmed.ncbi.nlm.nih.gov/19854049 DM2MJ9F DI DM2MJ9F DM2MJ9F DN 6-bromo-N-m-tolylquinazolin-4-amine DM2MJ9F MI TTHS256 DM2MJ9F MN Metabotropic glutamate receptor 5 (mGluR5) DM2MJ9F MT DTT DM2MJ9F MA Inhibitor DM2MJ9F RN Discovery and SAR of 6-substituted-4-anilinoquinazolines as non-competitive antagonists of mGlu5. Bioorg Med Chem Lett. 2009 Dec 1;19(23):6623-6. DM2MJ9F RU https://pubmed.ncbi.nlm.nih.gov/19854049 DM46GLQ DI DM46GLQ DM46GLQ DN 6-butyl-2,4-dipropylaminopyrimidine DM46GLQ MI TTZAYWL DM46GLQ MN Estrogen receptor (ESR) DM46GLQ MT DTT DM46GLQ MA Inhibitor DM46GLQ RN Blocking estrogen signaling after the hormone: pyrimidine-core inhibitors of estrogen receptor-coactivator binding. J Med Chem. 2008 Oct 23;51(20):6512-30. DM46GLQ RU https://pubmed.ncbi.nlm.nih.gov/18785725 DMWTMDH DI DMWTMDH DMWTMDH DN 6-Carboxyfluorescein DMWTMDH MI DTQ23VB DMWTMDH MN Organic anion transporter 1 (SLC22A6) DMWTMDH MT DTP DMWTMDH MA Substrate DMWTMDH RN Fluorescence-based assay for the interaction of small molecules with the human renal organic anion transporter 1. Anal Biochem. 2000 Jul 15;283(1):49-55. DMWTMDH RU http://www.ncbi.nlm.nih.gov/pubmed/10929807 DM9MPDK DI DM9MPDK DM9MPDK DN 6-Carboxymethyluracil DM9MPDK MI TTZPS91 DM9MPDK MN Dihydrothymine dehydrogenase (DPYD) DM9MPDK MT DTT DM9MPDK MA Inhibitor DM9MPDK RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DM9MPDK RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMW6320 DI DMW6320 DMW6320 DN 6-Chloro-1,2,3,4-tetrahydro-pyrazino[1,2-a]indole DMW6320 MI TTJQOD7 DMW6320 MN 5-HT 2A receptor (HTR2A) DMW6320 MT DTT DMW6320 MA Inhibitor DMW6320 RN Evaluation of isotryptamine derivatives at 5-HT(2) serotonin receptors. Bioorg Med Chem Lett. 2002 Jan 21;12(2):155-8. DMW6320 RU https://pubmed.ncbi.nlm.nih.gov/11755343 DMURJ34 DI DMURJ34 DMURJ34 DN 6-Chloro-1,4-dihydro-quinoxaline-2,3-dione DMURJ34 MI TTLD29N DMURJ34 MN Glutamate receptor ionotropic NMDA 1 (NMDAR1) DMURJ34 MT DTT DMURJ34 MA Inhibitor DMURJ34 RN 5-(N-oxyaza)-7-substituted-1,4-dihydroquinoxaline-2,3-diones: novel, systemically active and broad spectrum antagonists for NMDA/glycine, AMPA, and... J Med Chem. 1997 Oct 24;40(22):3679-86. DMURJ34 RU https://pubmed.ncbi.nlm.nih.gov/9357535 DMURJ34 DI DMURJ34 DMURJ34 DN 6-Chloro-1,4-dihydro-quinoxaline-2,3-dione DMURJ34 MI TTKJEMQ DMURJ34 MN Glutamate receptor ionotropic NMDA 2A (NMDAR2A) DMURJ34 MT DTT DMURJ34 MA Inhibitor DMURJ34 RN 5-(N-oxyaza)-7-substituted-1,4-dihydroquinoxaline-2,3-diones: novel, systemically active and broad spectrum antagonists for NMDA/glycine, AMPA, and... J Med Chem. 1997 Oct 24;40(22):3679-86. DMURJ34 RU https://pubmed.ncbi.nlm.nih.gov/9357535 DMURJ34 DI DMURJ34 DMURJ34 DN 6-Chloro-1,4-dihydro-quinoxaline-2,3-dione DMURJ34 MI TTN9D8E DMURJ34 MN Glutamate receptor ionotropic NMDA 2B (NMDAR2B) DMURJ34 MT DTT DMURJ34 MA Inhibitor DMURJ34 RN 5-(N-oxyaza)-7-substituted-1,4-dihydroquinoxaline-2,3-diones: novel, systemically active and broad spectrum antagonists for NMDA/glycine, AMPA, and... J Med Chem. 1997 Oct 24;40(22):3679-86. DMURJ34 RU https://pubmed.ncbi.nlm.nih.gov/9357535 DMKCBIL DI DMKCBIL DMKCBIL DN 6-chloro-1H-indazole DMKCBIL MI TTZUFI5 DMKCBIL MN Nitric-oxide synthase brain (NOS1) DMKCBIL MT DTT DMKCBIL MA Inhibitor DMKCBIL RN 4-substituted indazoles as new inhibitors of neuronal nitric oxide synthase. Bioorg Med Chem Lett. 2007 Jun 1;17(11):3177-80. DMKCBIL RU https://pubmed.ncbi.nlm.nih.gov/17395463 DMTWBOV DI DMTWBOV DMTWBOV DN 6-Chloro-2-(3-nitro-phenyl)-chromen-4-one DMTWBOV MI TT1MPAY DMTWBOV MN GABA(A) receptor alpha-1 (GABRA1) DMTWBOV MT DTT DMTWBOV MA Inhibitor DMTWBOV RN Synthesis of halogenated/nitrated flavone derivatives and evaluation of their affinity for the central benzodiazepine receptor, Bioorg. Med. Chem. Lett. 7(15):2003-2008 (1997). DMTWBOV RU http://www.sciencedirect.com/science/article/pii/S0960894X97003430 DMTWBOV DI DMTWBOV DMTWBOV DN 6-Chloro-2-(3-nitro-phenyl)-chromen-4-one DMTWBOV MI TTNJYV2 DMTWBOV MN Gamma-aminobutyric acid receptor (GAR) DMTWBOV MT DTT DMTWBOV MA Inhibitor DMTWBOV RN Synthesis of halogenated/nitrated flavone derivatives and evaluation of their affinity for the central benzodiazepine receptor, Bioorg. Med. Chem. Lett. 7(15):2003-2008 (1997). DMTWBOV RU http://www.sciencedirect.com/science/article/pii/S0960894X97003430 DMLMOC0 DI DMLMOC0 DMLMOC0 DN 6-Chloro-2-(4-hydroxy-phenyl)-benzooxazol-5-ol DMLMOC0 MI TTZAYWL DMLMOC0 MN Estrogen receptor (ESR) DMLMOC0 MT DTT DMLMOC0 MA Inhibitor DMLMOC0 RN Design and synthesis of aryl diphenolic azoles as potent and selective estrogen receptor-beta ligands. J Med Chem. 2004 Oct 7;47(21):5021-40. DMLMOC0 RU https://pubmed.ncbi.nlm.nih.gov/15456246 DMLMOC0 DI DMLMOC0 DMLMOC0 DN 6-Chloro-2-(4-hydroxy-phenyl)-benzooxazol-5-ol DMLMOC0 MI TTOM3J0 DMLMOC0 MN Estrogen receptor beta (ESR2) DMLMOC0 MT DTT DMLMOC0 MA Inhibitor DMLMOC0 RN Design and synthesis of aryl diphenolic azoles as potent and selective estrogen receptor-beta ligands. J Med Chem. 2004 Oct 7;47(21):5021-40. DMLMOC0 RU https://pubmed.ncbi.nlm.nih.gov/15456246 DM5FZDI DI DM5FZDI DM5FZDI DN 6-Chloro-2-phenyl-chromen-4-one DM5FZDI MI TT1MPAY DM5FZDI MN GABA(A) receptor alpha-1 (GABRA1) DM5FZDI MT DTT DM5FZDI MA Inhibitor DM5FZDI RN Synthesis of halogenated/nitrated flavone derivatives and evaluation of their affinity for the central benzodiazepine receptor, Bioorg. Med. Chem. Lett. 7(15):2003-2008 (1997). DM5FZDI RU http://www.sciencedirect.com/science/article/pii/S0960894X97003430 DM5FZDI DI DM5FZDI DM5FZDI DN 6-Chloro-2-phenyl-chromen-4-one DM5FZDI MI TTNJYV2 DM5FZDI MN Gamma-aminobutyric acid receptor (GAR) DM5FZDI MT DTT DM5FZDI MA Inhibitor DM5FZDI RN Synthesis of halogenated/nitrated flavone derivatives and evaluation of their affinity for the central benzodiazepine receptor, Bioorg. Med. Chem. Lett. 7(15):2003-2008 (1997). DM5FZDI RU http://www.sciencedirect.com/science/article/pii/S0960894X97003430 DMM41AQ DI DMM41AQ DMM41AQ DN 6-Chloro-2-piperazin-1-yl-quinoline DMM41AQ MI TT3ROYC DMM41AQ MN Serotonin transporter (SERT) DMM41AQ MT DTT DMM41AQ MA Inhibitor DMM41AQ RN Syntheses and binding affinities of 6-nitroquipazine analogues for serotonin transporter. Part 1. Bioorg Med Chem Lett. 2000 Jul 17;10(14):1559-62. DMM41AQ RU https://pubmed.ncbi.nlm.nih.gov/10915050 DMHJIN0 DI DMHJIN0 DMHJIN0 DN 6-Chloro-4-morpholin-4-yl-chromen-2-one DMHJIN0 MI TTK3PY9 DMHJIN0 MN DNA-dependent protein kinase catalytic (PRKDC) DMHJIN0 MT DTT DMHJIN0 MA Inhibitor DMHJIN0 RN Selective benzopyranone and pyrimido[2,1-a]isoquinolin-4-one inhibitors of DNA-dependent protein kinase: synthesis, structure-activity studies, and... J Med Chem. 2005 Jan 27;48(2):569-85. DMHJIN0 RU https://pubmed.ncbi.nlm.nih.gov/15658870 DMSZML2 DI DMSZML2 DMSZML2 DN 6-chloro-5-(2-thienyl)pyrimidine-2,4(1H,3H)-dione DMSZML2 MI TTO0IB8 DMSZML2 MN Thymidine phosphorylase (TYMP) DMSZML2 MT DTT DMSZML2 MA Inhibitor DMSZML2 RN Discovery of 5-substituted-6-chlorouracils as efficient inhibitors of human thymidine phosphorylase. J Med Chem. 2007 Nov 29;50(24):6016-23. DMSZML2 RU https://pubmed.ncbi.nlm.nih.gov/17963370 DMASFR6 DI DMASFR6 DMASFR6 DN 6-chloro-5-heptylpyrimidine-2,4(1H,3H)-dione DMASFR6 MI TTO0IB8 DMASFR6 MN Thymidine phosphorylase (TYMP) DMASFR6 MT DTT DMASFR6 MA Inhibitor DMASFR6 RN Discovery of 5-substituted-6-chlorouracils as efficient inhibitors of human thymidine phosphorylase. J Med Chem. 2007 Nov 29;50(24):6016-23. DMASFR6 RU https://pubmed.ncbi.nlm.nih.gov/17963370 DMP4V8Y DI DMP4V8Y DMP4V8Y DN 6-chloro-5-hexylpyrimidine-2,4(1H,3H)-dione DMP4V8Y MI TTO0IB8 DMP4V8Y MN Thymidine phosphorylase (TYMP) DMP4V8Y MT DTT DMP4V8Y MA Inhibitor DMP4V8Y RN Discovery of 5-substituted-6-chlorouracils as efficient inhibitors of human thymidine phosphorylase. J Med Chem. 2007 Nov 29;50(24):6016-23. DMP4V8Y RU https://pubmed.ncbi.nlm.nih.gov/17963370 DMUJSP7 DI DMUJSP7 DMUJSP7 DN 6-chloro-5-pentylpyrimidine-2,4(1H,3H)-dione DMUJSP7 MI TTO0IB8 DMUJSP7 MN Thymidine phosphorylase (TYMP) DMUJSP7 MT DTT DMUJSP7 MA Inhibitor DMUJSP7 RN Discovery of 5-substituted-6-chlorouracils as efficient inhibitors of human thymidine phosphorylase. J Med Chem. 2007 Nov 29;50(24):6016-23. DMUJSP7 RU https://pubmed.ncbi.nlm.nih.gov/17963370 DM90JMN DI DM90JMN DM90JMN DN 6-chloro-5-phenylpyrimidine-2,4(1H,3H)-dione DM90JMN MI TTO0IB8 DM90JMN MN Thymidine phosphorylase (TYMP) DM90JMN MT DTT DM90JMN MA Inhibitor DM90JMN RN Discovery of 5-substituted-6-chlorouracils as efficient inhibitors of human thymidine phosphorylase. J Med Chem. 2007 Nov 29;50(24):6016-23. DM90JMN RU https://pubmed.ncbi.nlm.nih.gov/17963370 DMB24LJ DI DMB24LJ DMB24LJ DN 6-chloro-5-propylpyrimidine-2,4(1H,3H)-dione DMB24LJ MI TTO0IB8 DMB24LJ MN Thymidine phosphorylase (TYMP) DMB24LJ MT DTT DMB24LJ MA Inhibitor DMB24LJ RN Discovery of 5-substituted-6-chlorouracils as efficient inhibitors of human thymidine phosphorylase. J Med Chem. 2007 Nov 29;50(24):6016-23. DMB24LJ RU https://pubmed.ncbi.nlm.nih.gov/17963370 DM10A9S DI DM10A9S DM10A9S DN 6-Chloro-N-(2-morpholinoethyl)nicotinamide DM10A9S MI TT3WG5C DM10A9S MN Monoamine oxidase type A (MAO-A) DM10A9S MT DTT DM10A9S MA Inhibitor DM10A9S RN Design of novel nicotinamides as potent and selective monoamine oxidase a inhibitors. Bioorg Med Chem. 2010 Feb 15;18(4):1659-64. DM10A9S RU https://pubmed.ncbi.nlm.nih.gov/20117937 DMPIFLA DI DMPIFLA DMPIFLA DN 6-chloro-N-(3-chlorophenyl)quinazolin-4-amine DMPIFLA MI TTGKNB4 DMPIFLA MN Epidermal growth factor receptor (EGFR) DMPIFLA MT DTT DMPIFLA MA Inhibitor DMPIFLA RN Discovery and SAR of 6-substituted-4-anilinoquinazolines as non-competitive antagonists of mGlu5. Bioorg Med Chem Lett. 2009 Dec 1;19(23):6623-6. DMPIFLA RU https://pubmed.ncbi.nlm.nih.gov/19854049 DMPIFLA DI DMPIFLA DMPIFLA DN 6-chloro-N-(3-chlorophenyl)quinazolin-4-amine DMPIFLA MI TTHS256 DMPIFLA MN Metabotropic glutamate receptor 5 (mGluR5) DMPIFLA MT DTT DMPIFLA MA Inhibitor DMPIFLA RN Discovery and SAR of 6-substituted-4-anilinoquinazolines as non-competitive antagonists of mGlu5. Bioorg Med Chem Lett. 2009 Dec 1;19(23):6623-6. DMPIFLA RU https://pubmed.ncbi.nlm.nih.gov/19854049 DM78I4P DI DM78I4P DM78I4P DN 6-Chloro-N-(3-morpholinopropyl)nicotinamide DM78I4P MI TT3WG5C DM78I4P MN Monoamine oxidase type A (MAO-A) DM78I4P MT DTT DM78I4P MA Inhibitor DM78I4P RN Design of novel nicotinamides as potent and selective monoamine oxidase a inhibitors. Bioorg Med Chem. 2010 Feb 15;18(4):1659-64. DM78I4P RU https://pubmed.ncbi.nlm.nih.gov/20117937 DMUY9TF DI DMUY9TF DMUY9TF DN 6-chloro-N-(pyridin-3-yl)indoline-1-carboxamide DMUY9TF MI TTJQOD7 DMUY9TF MN 5-HT 2A receptor (HTR2A) DMUY9TF MT DTT DMUY9TF MA Inhibitor DMUY9TF RN Synthesis and structure-affinity relationships of novel small molecule natural product derivatives capable of discriminating between serotonin 5-HT1A, 5-HT2A, 5-HT2C receptor subtypes. Bioorg Med Chem. 2010 Jul 1;18(13):4783-92. DMUY9TF RU https://pubmed.ncbi.nlm.nih.gov/20570529 DMUY9TF DI DMUY9TF DMUY9TF DN 6-chloro-N-(pyridin-3-yl)indoline-1-carboxamide DMUY9TF MI TTWJBZ5 DMUY9TF MN 5-HT 2C receptor (HTR2C) DMUY9TF MT DTT DMUY9TF MA Inhibitor DMUY9TF RN Synthesis and structure-affinity relationships of novel small molecule natural product derivatives capable of discriminating between serotonin 5-HT1A, 5-HT2A, 5-HT2C receptor subtypes. Bioorg Med Chem. 2010 Jul 1;18(13):4783-92. DMUY9TF RU https://pubmed.ncbi.nlm.nih.gov/20570529 DMWB43U DI DMWB43U DMWB43U DN 6-Chloropurine Riboside, 5'-Monophosphate DMWB43U MI TTZFTY4 DMWB43U MN Amidophosphoribosyltransferase (PPAT) DMWB43U MT DTT DMWB43U MA Inhibitor DMWB43U RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMWB43U RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMWB43U DI DMWB43U DMWB43U DN 6-Chloropurine Riboside, 5'-Monophosphate DMWB43U MI TTTB4UP DMWB43U MN Inosine-5'-monophosphate dehydrogenase 2 (IMPDH2) DMWB43U MT DTT DMWB43U MA Inhibitor DMWB43U RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMWB43U RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMV0C69 DI DMV0C69 DMV0C69 DN 6-chlorotacrine hydrochloride DMV0C69 MI TT1RS9F DMV0C69 MN Acetylcholinesterase (AChE) DMV0C69 MT DTT DMV0C69 MA Inhibitor DMV0C69 RN Pyrano[3,2-c]quinoline-6-chlorotacrine hybrids as a novel family of acetylcholinesterase- and beta-amyloid-directed anti-Alzheimer compounds. J Med Chem. 2009 Sep 10;52(17):5365-79. DMV0C69 RU https://pubmed.ncbi.nlm.nih.gov/19663388 DMV0C69 DI DMV0C69 DMV0C69 DN 6-chlorotacrine hydrochloride DMV0C69 MI TTEB0GD DMV0C69 MN Cholinesterase (BCHE) DMV0C69 MT DTT DMV0C69 MA Inhibitor DMV0C69 RN Pyrano[3,2-c]quinoline-6-chlorotacrine hybrids as a novel family of acetylcholinesterase- and beta-amyloid-directed anti-Alzheimer compounds. J Med Chem. 2009 Sep 10;52(17):5365-79. DMV0C69 RU https://pubmed.ncbi.nlm.nih.gov/19663388 DMPULH3 DI DMPULH3 DMPULH3 DN 6-cinnamoylhernandine DMPULH3 MI TT27RFC DMPULH3 MN Opioid receptor delta (OPRD1) DMPULH3 MT DTT DMPULH3 MA Inhibitor DMPULH3 RN Hasubanan alkaloids with delta-opioid binding affinity from the aerial parts of Stephania japonica. J Nat Prod. 2010 May 28;73(5):988-91. DMPULH3 RU https://pubmed.ncbi.nlm.nih.gov/20426456 DMPXS9F DI DMPXS9F DMPXS9F DN 6-cinnamoyl-N-methylstephasunoline DMPXS9F MI TT27RFC DMPXS9F MN Opioid receptor delta (OPRD1) DMPXS9F MT DTT DMPXS9F MA Inhibitor DMPXS9F RN Hasubanan alkaloids with delta-opioid binding affinity from the aerial parts of Stephania japonica. J Nat Prod. 2010 May 28;73(5):988-91. DMPXS9F RU https://pubmed.ncbi.nlm.nih.gov/20426456 DMNTDFV DI DMNTDFV DMNTDFV DN 6-Cl-IMP DMNTDFV MI TTL7C8Q DMNTDFV MN Inosine-5'-monophosphate dehydrogenase 1 (IMPDH1) DMNTDFV MT DTT DMNTDFV MA Inhibitor DMNTDFV RN Identification of the IMP binding site in the IMP dehydrogenase from Tritrichomonas foetus. Biochemistry. 1995 Oct 24;34(42):13889-94. DMNTDFV RU https://pubmed.ncbi.nlm.nih.gov/7577983 DMNTDFV DI DMNTDFV DMNTDFV DN 6-Cl-IMP DMNTDFV MI TTYQ4AE DMNTDFV MN Plasmodium Adenylosuccinate synthetase (Malaria Adss) DMNTDFV MT DTT DMNTDFV MA Inhibitor DMNTDFV RN High performance liquid chromatography analysis of hypoxanthine metabolism in mouse oocyte-cumulus cell complexes: effects of purine metabolic perturbants. Biol Reprod. 1994 Jun;50(6):1403-12. DMNTDFV RU https://pubmed.ncbi.nlm.nih.gov/8080928 DMKNOLV DI DMKNOLV DMKNOLV DN 6-Cl-MLT DMKNOLV MI TT0WAIE DMKNOLV MN Melatonin receptor type 1A (MTNR1A) DMKNOLV MT DTT DMKNOLV MA Agonist DMKNOLV RN Characterization of a retinal melatonin receptor. J Pharmacol Exp Ther. 1985 Aug;234(2):395-401. DMKNOLV RU https://pubmed.ncbi.nlm.nih.gov/2991499 DMACTDZ DI DMACTDZ DMACTDZ DN 6-CYCLOHEXYLMETHOXY-2-(3'-CHLOROANILINO) PURINE DMACTDZ MI TT7HF4W DMACTDZ MN Cyclin-dependent kinase 2 (CDK2) DMACTDZ MT DTT DMACTDZ MA Inhibitor DMACTDZ RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DMACTDZ RU https://pubmed.ncbi.nlm.nih.gov/10592235 DM9IHYS DI DM9IHYS DM9IHYS DN 6-Cyclohexylmethoxy-pyrimidine-2,4,5-triamine DM9IHYS MI TTAMQ62 DM9IHYS MN Cyclin A2 (CCNA2) DM9IHYS MT DTT DM9IHYS MA Inhibitor DM9IHYS RN 4-Alkoxy-2,6-diaminopyrimidine derivatives: inhibitors of cyclin dependent kinases 1 and 2. Bioorg Med Chem Lett. 2003 Jan 20;13(2):217-22. DM9IHYS RU https://pubmed.ncbi.nlm.nih.gov/12482427 DM9IHYS DI DM9IHYS DM9IHYS DN 6-Cyclohexylmethoxy-pyrimidine-2,4,5-triamine DM9IHYS MI TT7HF4W DM9IHYS MN Cyclin-dependent kinase 2 (CDK2) DM9IHYS MT DTT DM9IHYS MA Inhibitor DM9IHYS RN 4-Alkoxy-2,6-diaminopyrimidine derivatives: inhibitors of cyclin dependent kinases 1 and 2. Bioorg Med Chem Lett. 2003 Jan 20;13(2):217-22. DM9IHYS RU https://pubmed.ncbi.nlm.nih.gov/12482427 DM6UP25 DI DM6UP25 DM6UP25 DN 6-cyclohexylmethyloxy-2-(4'-hydroxyanilino)purine DM6UP25 MI TT7HF4W DM6UP25 MN Cyclin-dependent kinase 2 (CDK2) DM6UP25 MT DTT DM6UP25 MA Inhibitor DM6UP25 RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DM6UP25 RU https://pubmed.ncbi.nlm.nih.gov/10592235 DM9HBY5 DI DM9HBY5 DM9HBY5 DN 6-Deoxy-Alpha-D-Glucose DM9HBY5 MI TTHCF4J DM9HBY5 MN Alpha-glucosidase (GLA) DM9HBY5 MT DTT DM9HBY5 MA Inhibitor DM9HBY5 RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DM9HBY5 RU https://pubmed.ncbi.nlm.nih.gov/17139284 DM9HBY5 DI DM9HBY5 DM9HBY5 DN 6-Deoxy-Alpha-D-Glucose DM9HBY5 MI TTCGSZ4 DM9HBY5 MN Pancreatic alpha-amylase (AMY2A) DM9HBY5 MT DTT DM9HBY5 MA Inhibitor DM9HBY5 RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DM9HBY5 RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMKPWN0 DI DMKPWN0 DMKPWN0 DN 6-deoxymanzamine X DMKPWN0 MI TTRSMW9 DMKPWN0 MN Glycogen synthase kinase-3 beta (GSK-3B) DMKPWN0 MT DTT DMKPWN0 MA Inhibitor DMKPWN0 RN Glycogen synthase kinase-3 (GSK-3) inhibitory activity and structure-activity relationship (SAR) studies of the manzamine alkaloids. Potential for ... J Nat Prod. 2007 Sep;70(9):1397-405. DMKPWN0 RU https://pubmed.ncbi.nlm.nih.gov/17708655 DMGZQNS DI DMGZQNS DMGZQNS DN 6-desoxonaltrexone DMGZQNS MI TT27RFC DMGZQNS MN Opioid receptor delta (OPRD1) DMGZQNS MT DTT DMGZQNS MA Inhibitor DMGZQNS RN Syntheses of novel high affinity ligands for opioid receptors. Bioorg Med Chem Lett. 2009 Apr 15;19(8):2289-94. DMGZQNS RU https://pubmed.ncbi.nlm.nih.gov/19282177 DMGZQNS DI DMGZQNS DMGZQNS DN 6-desoxonaltrexone DMGZQNS MI TTQW87Y DMGZQNS MN Opioid receptor kappa (OPRK1) DMGZQNS MT DTT DMGZQNS MA Inhibitor DMGZQNS RN Syntheses of novel high affinity ligands for opioid receptors. Bioorg Med Chem Lett. 2009 Apr 15;19(8):2289-94. DMGZQNS RU https://pubmed.ncbi.nlm.nih.gov/19282177 DMGZQNS DI DMGZQNS DMGZQNS DN 6-desoxonaltrexone DMGZQNS MI TTKWM86 DMGZQNS MN Opioid receptor mu (MOP) DMGZQNS MT DTT DMGZQNS MA Inhibitor DMGZQNS RN Syntheses of novel high affinity ligands for opioid receptors. Bioorg Med Chem Lett. 2009 Apr 15;19(8):2289-94. DMGZQNS RU https://pubmed.ncbi.nlm.nih.gov/19282177 DML2AC1 DI DML2AC1 DML2AC1 DN 6-Dimethylamino-2-methyl-hex-4-ynal oxime DML2AC1 MI TTZ9SOR DML2AC1 MN Muscarinic acetylcholine receptor M1 (CHRM1) DML2AC1 MT DTT DML2AC1 MA Inhibitor DML2AC1 RN Cholinergic agents: aldehyde, ketone, and oxime analogues of the muscarinic agonist UH5, Bioorg. Med. Chem. Lett. 2(8):803-808 (1992). DML2AC1 RU http://www.sciencedirect.com/science/article/pii/S0960894X00805351 DML2AC1 DI DML2AC1 DML2AC1 DN 6-Dimethylamino-2-methyl-hex-4-ynal oxime DML2AC1 MI TTYEG6Q DML2AC1 MN Muscarinic acetylcholine receptor M2 (CHRM2) DML2AC1 MT DTT DML2AC1 MA Inhibitor DML2AC1 RN Cholinergic agents: aldehyde, ketone, and oxime analogues of the muscarinic agonist UH5, Bioorg. Med. Chem. Lett. 2(8):803-808 (1992). DML2AC1 RU http://www.sciencedirect.com/science/article/pii/S0960894X00805351 DML2AC1 DI DML2AC1 DML2AC1 DN 6-Dimethylamino-2-methyl-hex-4-ynal oxime DML2AC1 MI TTQ13Z5 DML2AC1 MN Muscarinic acetylcholine receptor M3 (CHRM3) DML2AC1 MT DTT DML2AC1 MA Inhibitor DML2AC1 RN Cholinergic agents: aldehyde, ketone, and oxime analogues of the muscarinic agonist UH5, Bioorg. Med. Chem. Lett. 2(8):803-808 (1992). DML2AC1 RU http://www.sciencedirect.com/science/article/pii/S0960894X00805351 DML2AC1 DI DML2AC1 DML2AC1 DN 6-Dimethylamino-2-methyl-hex-4-ynal oxime DML2AC1 MI TTQ3JTF DML2AC1 MN Muscarinic acetylcholine receptor M4 (CHRM4) DML2AC1 MT DTT DML2AC1 MA Inhibitor DML2AC1 RN Cholinergic agents: aldehyde, ketone, and oxime analogues of the muscarinic agonist UH5, Bioorg. Med. Chem. Lett. 2(8):803-808 (1992). DML2AC1 RU http://www.sciencedirect.com/science/article/pii/S0960894X00805351 DML2AC1 DI DML2AC1 DML2AC1 DN 6-Dimethylamino-2-methyl-hex-4-ynal oxime DML2AC1 MI TTH18TF DML2AC1 MN Muscarinic acetylcholine receptor M5 (CHRM5) DML2AC1 MT DTT DML2AC1 MA Inhibitor DML2AC1 RN Cholinergic agents: aldehyde, ketone, and oxime analogues of the muscarinic agonist UH5, Bioorg. Med. Chem. Lett. 2(8):803-808 (1992). DML2AC1 RU http://www.sciencedirect.com/science/article/pii/S0960894X00805351 DMBMRUI DI DMBMRUI DMBMRUI DN 6-ethyl-2,4-diisobutylaminopyrimidine DMBMRUI MI TTZAYWL DMBMRUI MN Estrogen receptor (ESR) DMBMRUI MT DTT DMBMRUI MA Inhibitor DMBMRUI RN Blocking estrogen signaling after the hormone: pyrimidine-core inhibitors of estrogen receptor-coactivator binding. J Med Chem. 2008 Oct 23;51(20):6512-30. DMBMRUI RU https://pubmed.ncbi.nlm.nih.gov/18785725 DMUHOF4 DI DMUHOF4 DMUHOF4 DN 6-Ethyl-2-phenyl-chromen-4-one DMUHOF4 MI TTNJYV2 DMUHOF4 MN Gamma-aminobutyric acid receptor (GAR) DMUHOF4 MT DTT DMUHOF4 MA Inhibitor DMUHOF4 RN Refinement and evaluation of a pharmacophore model for flavone derivatives binding to the benzodiazepine site of the GABA(A) receptor. J Med Chem. 2002 Sep 12;45(19):4188-201. DMUHOF4 RU https://pubmed.ncbi.nlm.nih.gov/12213060 DMLEUP2 DI DMLEUP2 DMLEUP2 DN 6-ethyl-3-(2-ethylbutoxycarbonyl)-4-quinolone DMLEUP2 MI TT1MPAY DMLEUP2 MN GABA(A) receptor alpha-1 (GABRA1) DMLEUP2 MT DTT DMLEUP2 MA Inhibitor DMLEUP2 RN 4-quinolone derivatives: high-affinity ligands at the benzodiazepine site of brain GABA A receptors. synthesis, pharmacology, and pharmacophore mod... J Med Chem. 2006 Apr 20;49(8):2526-33. DMLEUP2 RU https://pubmed.ncbi.nlm.nih.gov/16610795 DMLEUP2 DI DMLEUP2 DMLEUP2 DN 6-ethyl-3-(2-ethylbutoxycarbonyl)-4-quinolone DMLEUP2 MI TTZA1NY DMLEUP2 MN GABA(A) receptor beta-2 (GABRB2) DMLEUP2 MT DTT DMLEUP2 MA Inhibitor DMLEUP2 RN 4-quinolone derivatives: high-affinity ligands at the benzodiazepine site of brain GABA A receptors. synthesis, pharmacology, and pharmacophore mod... J Med Chem. 2006 Apr 20;49(8):2526-33. DMLEUP2 RU https://pubmed.ncbi.nlm.nih.gov/16610795 DMLEUP2 DI DMLEUP2 DMLEUP2 DN 6-ethyl-3-(2-ethylbutoxycarbonyl)-4-quinolone DMLEUP2 MI TT06RH5 DMLEUP2 MN GABA(A) receptor gamma-2 (GABRG2) DMLEUP2 MT DTT DMLEUP2 MA Inhibitor DMLEUP2 RN 4-quinolone derivatives: high-affinity ligands at the benzodiazepine site of brain GABA A receptors. synthesis, pharmacology, and pharmacophore mod... J Med Chem. 2006 Apr 20;49(8):2526-33. DMLEUP2 RU https://pubmed.ncbi.nlm.nih.gov/16610795 DMLEUP2 DI DMLEUP2 DMLEUP2 DN 6-ethyl-3-(2-ethylbutoxycarbonyl)-4-quinolone DMLEUP2 MI TTNJYV2 DMLEUP2 MN Gamma-aminobutyric acid receptor (GAR) DMLEUP2 MT DTT DMLEUP2 MA Inhibitor DMLEUP2 RN 4-quinolone derivatives: high-affinity ligands at the benzodiazepine site of brain GABA A receptors. synthesis, pharmacology, and pharmacophore mod... J Med Chem. 2006 Apr 20;49(8):2526-33. DMLEUP2 RU https://pubmed.ncbi.nlm.nih.gov/16610795 DMESU53 DI DMESU53 DMESU53 DN 6-ethyl-3-(2-methylbutoxycarbonyl)-4-quinolone DMESU53 MI TT1MPAY DMESU53 MN GABA(A) receptor alpha-1 (GABRA1) DMESU53 MT DTT DMESU53 MA Inhibitor DMESU53 RN 4-quinolone derivatives: high-affinity ligands at the benzodiazepine site of brain GABA A receptors. synthesis, pharmacology, and pharmacophore mod... J Med Chem. 2006 Apr 20;49(8):2526-33. DMESU53 RU https://pubmed.ncbi.nlm.nih.gov/16610795 DMESU53 DI DMESU53 DMESU53 DN 6-ethyl-3-(2-methylbutoxycarbonyl)-4-quinolone DMESU53 MI TTZA1NY DMESU53 MN GABA(A) receptor beta-2 (GABRB2) DMESU53 MT DTT DMESU53 MA Inhibitor DMESU53 RN 4-quinolone derivatives: high-affinity ligands at the benzodiazepine site of brain GABA A receptors. synthesis, pharmacology, and pharmacophore mod... J Med Chem. 2006 Apr 20;49(8):2526-33. DMESU53 RU https://pubmed.ncbi.nlm.nih.gov/16610795 DMESU53 DI DMESU53 DMESU53 DN 6-ethyl-3-(2-methylbutoxycarbonyl)-4-quinolone DMESU53 MI TT06RH5 DMESU53 MN GABA(A) receptor gamma-2 (GABRG2) DMESU53 MT DTT DMESU53 MA Inhibitor DMESU53 RN 4-quinolone derivatives: high-affinity ligands at the benzodiazepine site of brain GABA A receptors. synthesis, pharmacology, and pharmacophore mod... J Med Chem. 2006 Apr 20;49(8):2526-33. DMESU53 RU https://pubmed.ncbi.nlm.nih.gov/16610795 DMESU53 DI DMESU53 DMESU53 DN 6-ethyl-3-(2-methylbutoxycarbonyl)-4-quinolone DMESU53 MI TTNJYV2 DMESU53 MN Gamma-aminobutyric acid receptor (GAR) DMESU53 MT DTT DMESU53 MA Inhibitor DMESU53 RN 4-quinolone derivatives: high-affinity ligands at the benzodiazepine site of brain GABA A receptors. synthesis, pharmacology, and pharmacophore mod... J Med Chem. 2006 Apr 20;49(8):2526-33. DMESU53 RU https://pubmed.ncbi.nlm.nih.gov/16610795 DM1POEA DI DM1POEA DM1POEA DN 6-ethyl-3-(3-methylbutoxycarbonyl)-4-quinolone DM1POEA MI TT1MPAY DM1POEA MN GABA(A) receptor alpha-1 (GABRA1) DM1POEA MT DTT DM1POEA MA Inhibitor DM1POEA RN 4-quinolone derivatives: high-affinity ligands at the benzodiazepine site of brain GABA A receptors. synthesis, pharmacology, and pharmacophore mod... J Med Chem. 2006 Apr 20;49(8):2526-33. DM1POEA RU https://pubmed.ncbi.nlm.nih.gov/16610795 DM1POEA DI DM1POEA DM1POEA DN 6-ethyl-3-(3-methylbutoxycarbonyl)-4-quinolone DM1POEA MI TT37EDJ DM1POEA MN GABA(A) receptor alpha-3 (GABRA3) DM1POEA MT DTT DM1POEA MA Inhibitor DM1POEA RN 4-quinolone derivatives: high-affinity ligands at the benzodiazepine site of brain GABA A receptors. synthesis, pharmacology, and pharmacophore mod... J Med Chem. 2006 Apr 20;49(8):2526-33. DM1POEA RU https://pubmed.ncbi.nlm.nih.gov/16610795 DM1POEA DI DM1POEA DM1POEA DN 6-ethyl-3-(3-methylbutoxycarbonyl)-4-quinolone DM1POEA MI TTZA1NY DM1POEA MN GABA(A) receptor beta-2 (GABRB2) DM1POEA MT DTT DM1POEA MA Inhibitor DM1POEA RN 4-quinolone derivatives: high-affinity ligands at the benzodiazepine site of brain GABA A receptors. synthesis, pharmacology, and pharmacophore mod... J Med Chem. 2006 Apr 20;49(8):2526-33. DM1POEA RU https://pubmed.ncbi.nlm.nih.gov/16610795 DM1POEA DI DM1POEA DM1POEA DN 6-ethyl-3-(3-methylbutoxycarbonyl)-4-quinolone DM1POEA MI TT06RH5 DM1POEA MN GABA(A) receptor gamma-2 (GABRG2) DM1POEA MT DTT DM1POEA MA Inhibitor DM1POEA RN 4-quinolone derivatives: high-affinity ligands at the benzodiazepine site of brain GABA A receptors. synthesis, pharmacology, and pharmacophore mod... J Med Chem. 2006 Apr 20;49(8):2526-33. DM1POEA RU https://pubmed.ncbi.nlm.nih.gov/16610795 DM1POEA DI DM1POEA DM1POEA DN 6-ethyl-3-(3-methylbutoxycarbonyl)-4-quinolone DM1POEA MI TTNJYV2 DM1POEA MN Gamma-aminobutyric acid receptor (GAR) DM1POEA MT DTT DM1POEA MA Inhibitor DM1POEA RN 4-quinolone derivatives: high-affinity ligands at the benzodiazepine site of brain GABA A receptors. synthesis, pharmacology, and pharmacophore mod... J Med Chem. 2006 Apr 20;49(8):2526-33. DM1POEA RU https://pubmed.ncbi.nlm.nih.gov/16610795 DMG05V1 DI DMG05V1 DMG05V1 DN 6-ethyl-3-(3-pentoxycarbonyl)-4-quinolone DMG05V1 MI TT1MPAY DMG05V1 MN GABA(A) receptor alpha-1 (GABRA1) DMG05V1 MT DTT DMG05V1 MA Inhibitor DMG05V1 RN 4-quinolone derivatives: high-affinity ligands at the benzodiazepine site of brain GABA A receptors. synthesis, pharmacology, and pharmacophore mod... J Med Chem. 2006 Apr 20;49(8):2526-33. DMG05V1 RU https://pubmed.ncbi.nlm.nih.gov/16610795 DMG05V1 DI DMG05V1 DMG05V1 DN 6-ethyl-3-(3-pentoxycarbonyl)-4-quinolone DMG05V1 MI TTZA1NY DMG05V1 MN GABA(A) receptor beta-2 (GABRB2) DMG05V1 MT DTT DMG05V1 MA Inhibitor DMG05V1 RN 4-quinolone derivatives: high-affinity ligands at the benzodiazepine site of brain GABA A receptors. synthesis, pharmacology, and pharmacophore mod... J Med Chem. 2006 Apr 20;49(8):2526-33. DMG05V1 RU https://pubmed.ncbi.nlm.nih.gov/16610795 DMG05V1 DI DMG05V1 DMG05V1 DN 6-ethyl-3-(3-pentoxycarbonyl)-4-quinolone DMG05V1 MI TT06RH5 DMG05V1 MN GABA(A) receptor gamma-2 (GABRG2) DMG05V1 MT DTT DMG05V1 MA Inhibitor DMG05V1 RN 4-quinolone derivatives: high-affinity ligands at the benzodiazepine site of brain GABA A receptors. synthesis, pharmacology, and pharmacophore mod... J Med Chem. 2006 Apr 20;49(8):2526-33. DMG05V1 RU https://pubmed.ncbi.nlm.nih.gov/16610795 DMG05V1 DI DMG05V1 DMG05V1 DN 6-ethyl-3-(3-pentoxycarbonyl)-4-quinolone DMG05V1 MI TTNJYV2 DMG05V1 MN Gamma-aminobutyric acid receptor (GAR) DMG05V1 MT DTT DMG05V1 MA Inhibitor DMG05V1 RN 4-quinolone derivatives: high-affinity ligands at the benzodiazepine site of brain GABA A receptors. synthesis, pharmacology, and pharmacophore mod... J Med Chem. 2006 Apr 20;49(8):2526-33. DMG05V1 RU https://pubmed.ncbi.nlm.nih.gov/16610795 DML9EU7 DI DML9EU7 DML9EU7 DN 6-ethyl-3-i-propoxycarbonyl-4-quinolone DML9EU7 MI TT1MPAY DML9EU7 MN GABA(A) receptor alpha-1 (GABRA1) DML9EU7 MT DTT DML9EU7 MA Inhibitor DML9EU7 RN 4-quinolone derivatives: high-affinity ligands at the benzodiazepine site of brain GABA A receptors. synthesis, pharmacology, and pharmacophore mod... J Med Chem. 2006 Apr 20;49(8):2526-33. DML9EU7 RU https://pubmed.ncbi.nlm.nih.gov/16610795 DML9EU7 DI DML9EU7 DML9EU7 DN 6-ethyl-3-i-propoxycarbonyl-4-quinolone DML9EU7 MI TTZA1NY DML9EU7 MN GABA(A) receptor beta-2 (GABRB2) DML9EU7 MT DTT DML9EU7 MA Inhibitor DML9EU7 RN 4-quinolone derivatives: high-affinity ligands at the benzodiazepine site of brain GABA A receptors. synthesis, pharmacology, and pharmacophore mod... J Med Chem. 2006 Apr 20;49(8):2526-33. DML9EU7 RU https://pubmed.ncbi.nlm.nih.gov/16610795 DML9EU7 DI DML9EU7 DML9EU7 DN 6-ethyl-3-i-propoxycarbonyl-4-quinolone DML9EU7 MI TT06RH5 DML9EU7 MN GABA(A) receptor gamma-2 (GABRG2) DML9EU7 MT DTT DML9EU7 MA Inhibitor DML9EU7 RN 4-quinolone derivatives: high-affinity ligands at the benzodiazepine site of brain GABA A receptors. synthesis, pharmacology, and pharmacophore mod... J Med Chem. 2006 Apr 20;49(8):2526-33. DML9EU7 RU https://pubmed.ncbi.nlm.nih.gov/16610795 DML9EU7 DI DML9EU7 DML9EU7 DN 6-ethyl-3-i-propoxycarbonyl-4-quinolone DML9EU7 MI TTNJYV2 DML9EU7 MN Gamma-aminobutyric acid receptor (GAR) DML9EU7 MT DTT DML9EU7 MA Inhibitor DML9EU7 RN 4-quinolone derivatives: high-affinity ligands at the benzodiazepine site of brain GABA A receptors. synthesis, pharmacology, and pharmacophore mod... J Med Chem. 2006 Apr 20;49(8):2526-33. DML9EU7 RU https://pubmed.ncbi.nlm.nih.gov/16610795 DMSGJM6 DI DMSGJM6 DMSGJM6 DN 6-ethyl-3-pentoxycarbonyl-4-quinolone DMSGJM6 MI TT1MPAY DMSGJM6 MN GABA(A) receptor alpha-1 (GABRA1) DMSGJM6 MT DTT DMSGJM6 MA Inhibitor DMSGJM6 RN 4-quinolone derivatives: high-affinity ligands at the benzodiazepine site of brain GABA A receptors. synthesis, pharmacology, and pharmacophore mod... J Med Chem. 2006 Apr 20;49(8):2526-33. DMSGJM6 RU https://pubmed.ncbi.nlm.nih.gov/16610795 DMSGJM6 DI DMSGJM6 DMSGJM6 DN 6-ethyl-3-pentoxycarbonyl-4-quinolone DMSGJM6 MI TTZA1NY DMSGJM6 MN GABA(A) receptor beta-2 (GABRB2) DMSGJM6 MT DTT DMSGJM6 MA Inhibitor DMSGJM6 RN 4-quinolone derivatives: high-affinity ligands at the benzodiazepine site of brain GABA A receptors. synthesis, pharmacology, and pharmacophore mod... J Med Chem. 2006 Apr 20;49(8):2526-33. DMSGJM6 RU https://pubmed.ncbi.nlm.nih.gov/16610795 DMSGJM6 DI DMSGJM6 DMSGJM6 DN 6-ethyl-3-pentoxycarbonyl-4-quinolone DMSGJM6 MI TT06RH5 DMSGJM6 MN GABA(A) receptor gamma-2 (GABRG2) DMSGJM6 MT DTT DMSGJM6 MA Inhibitor DMSGJM6 RN 4-quinolone derivatives: high-affinity ligands at the benzodiazepine site of brain GABA A receptors. synthesis, pharmacology, and pharmacophore mod... J Med Chem. 2006 Apr 20;49(8):2526-33. DMSGJM6 RU https://pubmed.ncbi.nlm.nih.gov/16610795 DMSGJM6 DI DMSGJM6 DMSGJM6 DN 6-ethyl-3-pentoxycarbonyl-4-quinolone DMSGJM6 MI TTNJYV2 DMSGJM6 MN Gamma-aminobutyric acid receptor (GAR) DMSGJM6 MT DTT DMSGJM6 MA Inhibitor DMSGJM6 RN 4-quinolone derivatives: high-affinity ligands at the benzodiazepine site of brain GABA A receptors. synthesis, pharmacology, and pharmacophore mod... J Med Chem. 2006 Apr 20;49(8):2526-33. DMSGJM6 RU https://pubmed.ncbi.nlm.nih.gov/16610795 DMGVI08 DI DMGVI08 DMGVI08 DN 6-ethyl-3-propoxycarbonyl-4-quinolone DMGVI08 MI TT1MPAY DMGVI08 MN GABA(A) receptor alpha-1 (GABRA1) DMGVI08 MT DTT DMGVI08 MA Inhibitor DMGVI08 RN 4-quinolone derivatives: high-affinity ligands at the benzodiazepine site of brain GABA A receptors. synthesis, pharmacology, and pharmacophore mod... J Med Chem. 2006 Apr 20;49(8):2526-33. DMGVI08 RU https://pubmed.ncbi.nlm.nih.gov/16610795 DMGVI08 DI DMGVI08 DMGVI08 DN 6-ethyl-3-propoxycarbonyl-4-quinolone DMGVI08 MI TTZA1NY DMGVI08 MN GABA(A) receptor beta-2 (GABRB2) DMGVI08 MT DTT DMGVI08 MA Inhibitor DMGVI08 RN 4-quinolone derivatives: high-affinity ligands at the benzodiazepine site of brain GABA A receptors. synthesis, pharmacology, and pharmacophore mod... J Med Chem. 2006 Apr 20;49(8):2526-33. DMGVI08 RU https://pubmed.ncbi.nlm.nih.gov/16610795 DMGVI08 DI DMGVI08 DMGVI08 DN 6-ethyl-3-propoxycarbonyl-4-quinolone DMGVI08 MI TT06RH5 DMGVI08 MN GABA(A) receptor gamma-2 (GABRG2) DMGVI08 MT DTT DMGVI08 MA Inhibitor DMGVI08 RN 4-quinolone derivatives: high-affinity ligands at the benzodiazepine site of brain GABA A receptors. synthesis, pharmacology, and pharmacophore mod... J Med Chem. 2006 Apr 20;49(8):2526-33. DMGVI08 RU https://pubmed.ncbi.nlm.nih.gov/16610795 DMGVI08 DI DMGVI08 DMGVI08 DN 6-ethyl-3-propoxycarbonyl-4-quinolone DMGVI08 MI TTNJYV2 DMGVI08 MN Gamma-aminobutyric acid receptor (GAR) DMGVI08 MT DTT DMGVI08 MA Inhibitor DMGVI08 RN 4-quinolone derivatives: high-affinity ligands at the benzodiazepine site of brain GABA A receptors. synthesis, pharmacology, and pharmacophore mod... J Med Chem. 2006 Apr 20;49(8):2526-33. DMGVI08 RU https://pubmed.ncbi.nlm.nih.gov/16610795 DMC1F2E DI DMC1F2E DMC1F2E DN 6-ethyl-3-propylaminocarbonyl-4-quinolone DMC1F2E MI TT1MPAY DMC1F2E MN GABA(A) receptor alpha-1 (GABRA1) DMC1F2E MT DTT DMC1F2E MA Inhibitor DMC1F2E RN 4-quinolone derivatives: high-affinity ligands at the benzodiazepine site of brain GABA A receptors. synthesis, pharmacology, and pharmacophore mod... J Med Chem. 2006 Apr 20;49(8):2526-33. DMC1F2E RU https://pubmed.ncbi.nlm.nih.gov/16610795 DMC1F2E DI DMC1F2E DMC1F2E DN 6-ethyl-3-propylaminocarbonyl-4-quinolone DMC1F2E MI TTZA1NY DMC1F2E MN GABA(A) receptor beta-2 (GABRB2) DMC1F2E MT DTT DMC1F2E MA Inhibitor DMC1F2E RN 4-quinolone derivatives: high-affinity ligands at the benzodiazepine site of brain GABA A receptors. synthesis, pharmacology, and pharmacophore mod... J Med Chem. 2006 Apr 20;49(8):2526-33. DMC1F2E RU https://pubmed.ncbi.nlm.nih.gov/16610795 DMC1F2E DI DMC1F2E DMC1F2E DN 6-ethyl-3-propylaminocarbonyl-4-quinolone DMC1F2E MI TT06RH5 DMC1F2E MN GABA(A) receptor gamma-2 (GABRG2) DMC1F2E MT DTT DMC1F2E MA Inhibitor DMC1F2E RN 4-quinolone derivatives: high-affinity ligands at the benzodiazepine site of brain GABA A receptors. synthesis, pharmacology, and pharmacophore mod... J Med Chem. 2006 Apr 20;49(8):2526-33. DMC1F2E RU https://pubmed.ncbi.nlm.nih.gov/16610795 DMC1F2E DI DMC1F2E DMC1F2E DN 6-ethyl-3-propylaminocarbonyl-4-quinolone DMC1F2E MI TTNJYV2 DMC1F2E MN Gamma-aminobutyric acid receptor (GAR) DMC1F2E MT DTT DMC1F2E MA Inhibitor DMC1F2E RN 4-quinolone derivatives: high-affinity ligands at the benzodiazepine site of brain GABA A receptors. synthesis, pharmacology, and pharmacophore mod... J Med Chem. 2006 Apr 20;49(8):2526-33. DMC1F2E RU https://pubmed.ncbi.nlm.nih.gov/16610795 DMOGETD DI DMOGETD DMOGETD DN 6-ethyl-4,7-dimethyl-6H-benzo[c]chromene-3,8-diol DMOGETD MI TTZAYWL DMOGETD MN Estrogen receptor (ESR) DMOGETD MT DTT DMOGETD MA Inhibitor DMOGETD RN 6H-Benzo[c]chromen-6-one derivatives as selective ERbeta agonists. Bioorg Med Chem Lett. 2006 Mar 15;16(6):1468-72. DMOGETD RU https://pubmed.ncbi.nlm.nih.gov/16412638 DMOGETD DI DMOGETD DMOGETD DN 6-ethyl-4,7-dimethyl-6H-benzo[c]chromene-3,8-diol DMOGETD MI TTOM3J0 DMOGETD MN Estrogen receptor beta (ESR2) DMOGETD MT DTT DMOGETD MA Inhibitor DMOGETD RN 6H-Benzo[c]chromen-6-one derivatives as selective ERbeta agonists. Bioorg Med Chem Lett. 2006 Mar 15;16(6):1468-72. DMOGETD RU https://pubmed.ncbi.nlm.nih.gov/16412638 DM9OD7U DI DM9OD7U DM9OD7U DN 6-ETHYL-5-PHENYLPYRIMIDINE-2,4-DIAMINE DM9OD7U MI TTU6BFZ DM9OD7U MN Candida Thymidylate synthase (Candi TMP1) DM9OD7U MT DTT DM9OD7U MA Inhibitor DM9OD7U RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DM9OD7U RU https://pubmed.ncbi.nlm.nih.gov/10592235 DME4GBS DI DME4GBS DME4GBS DN 6-ethylamino-2-(3''-indolyl)ethyloxy)adenosine DME4GBS MI TTK25J1 DME4GBS MN Adenosine A1 receptor (ADORA1) DME4GBS MT DTT DME4GBS MA Inhibitor DME4GBS RN Structure-activity relationships of 2,N(6),5'-substituted adenosine derivatives with potent activity at the A2B adenosine receptor. J Med Chem. 2007 Apr 19;50(8):1810-27. DME4GBS RU https://pubmed.ncbi.nlm.nih.gov/17378544 DME4GBS DI DME4GBS DME4GBS DN 6-ethylamino-2-(3''-indolyl)ethyloxy)adenosine DME4GBS MI TTJFY5U DME4GBS MN Adenosine A3 receptor (ADORA3) DME4GBS MT DTT DME4GBS MA Inhibitor DME4GBS RN Structure-activity relationships of 2,N(6),5'-substituted adenosine derivatives with potent activity at the A2B adenosine receptor. J Med Chem. 2007 Apr 19;50(8):1810-27. DME4GBS RU https://pubmed.ncbi.nlm.nih.gov/17378544 DMPZIV0 DI DMPZIV0 DMPZIV0 DN 6-Fluoro-2-(3-nitro-phenyl)-chromen-4-one DMPZIV0 MI TT1MPAY DMPZIV0 MN GABA(A) receptor alpha-1 (GABRA1) DMPZIV0 MT DTT DMPZIV0 MA Inhibitor DMPZIV0 RN Synthesis of halogenated/nitrated flavone derivatives and evaluation of their affinity for the central benzodiazepine receptor, Bioorg. Med. Chem. Lett. 7(15):2003-2008 (1997). DMPZIV0 RU http://www.sciencedirect.com/science/article/pii/S0960894X97003430 DMPZIV0 DI DMPZIV0 DMPZIV0 DN 6-Fluoro-2-(3-nitro-phenyl)-chromen-4-one DMPZIV0 MI TTNJYV2 DMPZIV0 MN Gamma-aminobutyric acid receptor (GAR) DMPZIV0 MT DTT DMPZIV0 MA Inhibitor DMPZIV0 RN Synthesis of halogenated/nitrated flavone derivatives and evaluation of their affinity for the central benzodiazepine receptor, Bioorg. Med. Chem. Lett. 7(15):2003-2008 (1997). DMPZIV0 RU http://www.sciencedirect.com/science/article/pii/S0960894X97003430 DM2DTHV DI DM2DTHV DM2DTHV DN 6-fluoro-2-methyl-9H-carbazole DM2DTHV MI TTBGTCW DM2DTHV MN Kinesin spindle messenger RNA (KIF11 mRNA) DM2DTHV MT DTT DM2DTHV MA Inhibitor DM2DTHV RN Kinesin spindle protein (KSP) inhibitors with 2,3-fused indole scaffolds. J Med Chem. 2010 Jul 8;53(13):5054-8. DM2DTHV RU https://pubmed.ncbi.nlm.nih.gov/20521839 DM4Q5TX DI DM4Q5TX DM4Q5TX DN 6-fluoro-5-phenylpyrimidine-2,4(1H,3H)-dione DM4Q5TX MI TTO0IB8 DM4Q5TX MN Thymidine phosphorylase (TYMP) DM4Q5TX MT DTT DM4Q5TX MA Inhibitor DM4Q5TX RN Discovery of 5-substituted-6-chlorouracils as efficient inhibitors of human thymidine phosphorylase. J Med Chem. 2007 Nov 29;50(24):6016-23. DM4Q5TX RU https://pubmed.ncbi.nlm.nih.gov/17963370 DMKFUO0 DI DMKFUO0 DMKFUO0 DN 6-Fluoromelatonin DMKFUO0 MI TT0K1SC DMKFUO0 MN 5-HT 2B receptor (HTR2B) DMKFUO0 MT DTT DMKFUO0 MA Inhibitor DMKFUO0 RN Development, validation, and use of quantitative structure-activity relationship models of 5-hydroxytryptamine (2B) receptor ligands to identify no... J Med Chem. 2010 Nov 11;53(21):7573-86. DMKFUO0 RU https://pubmed.ncbi.nlm.nih.gov/20958049 DMPZ92X DI DMPZ92X DMPZ92X DN 6-fluoromevalonate 5-diphosphate DMPZ92X MI TTE5J6X DMPZ92X MN Diphosphomevalonate decarboxylase (MVD) DMPZ92X MT DTT DMPZ92X MA Inhibitor DMPZ92X RN Human mevalonate diphosphate decarboxylase: characterization, investigation of the mevalonate diphosphate binding site, and crystal structure. Arch Biochem Biophys. 2008 Dec 1;480(1):58-67. DMPZ92X RU https://pubmed.ncbi.nlm.nih.gov/18823933 DMZ26LS DI DMZ26LS DMZ26LS DN 6-fluoromevalonate pyrophosphate DMZ26LS MI TTE5J6X DMZ26LS MN Diphosphomevalonate decarboxylase (MVD) DMZ26LS MT DTT DMZ26LS MA Inhibitor DMZ26LS RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 642). DMZ26LS RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=642 DMA1QH0 DI DMA1QH0 DMA1QH0 DN 6-Fluoro-N-(2-morpholinoethyl)nicotinamide DMA1QH0 MI TT3WG5C DMA1QH0 MN Monoamine oxidase type A (MAO-A) DMA1QH0 MT DTT DMA1QH0 MA Inhibitor DMA1QH0 RN Design of novel nicotinamides as potent and selective monoamine oxidase a inhibitors. Bioorg Med Chem. 2010 Feb 15;18(4):1659-64. DMA1QH0 RU https://pubmed.ncbi.nlm.nih.gov/20117937 DMVADTP DI DMVADTP DMVADTP DN 6-fluoro-N-m-tolylquinazolin-4-amine DMVADTP MI TTHS256 DMVADTP MN Metabotropic glutamate receptor 5 (mGluR5) DMVADTP MT DTT DMVADTP MA Inhibitor DMVADTP RN Discovery and SAR of 6-substituted-4-anilinoquinazolines as non-competitive antagonists of mGlu5. Bioorg Med Chem Lett. 2009 Dec 1;19(23):6623-6. DMVADTP RU https://pubmed.ncbi.nlm.nih.gov/19854049 DMF2RGY DI DMF2RGY DMF2RGY DN 6-fluoro-noradrenaline DMF2RGY MI TT2NUT5 DMF2RGY MN Adrenergic receptor alpha-2C (ADRA2C) DMF2RGY MT DTT DMF2RGY MA Agonist DMF2RGY RN Selectivity of agonists for cloned alpha 1-adrenergic receptor subtypes. Mol Pharmacol. 1994 Nov;46(5):929-36. DMF2RGY RU https://pubmed.ncbi.nlm.nih.gov/7969082 DMPWXI8 DI DMPWXI8 DMPWXI8 DN 6-fluoronorepinehprine DMPWXI8 MI TTBRKXS DMPWXI8 MN Adrenergic receptor alpha-1B (ADRA1B) DMPWXI8 MT DTT DMPWXI8 MA Inhibitor DMPWXI8 RN Structural basis of the selectivity of the beta(2)-adrenergic receptor for fluorinated catecholamines. Bioorg Med Chem. 2009 Dec 1;17(23):7987-92. DMPWXI8 RU https://pubmed.ncbi.nlm.nih.gov/19857969 DMS325C DI DMS325C DMS325C DN 6-fluoropyridin-3-ylboronic acid DMS325C MI TTDP1UC DMS325C MN Fatty acid amide hydrolase (FAAH) DMS325C MT DTT DMS325C MA Inhibitor DMS325C RN Discovery of boronic acids as novel and potent inhibitors of fatty acid amide hydrolase. J Med Chem. 2008 Nov 27;51(22):7057-60. DMS325C RU https://pubmed.ncbi.nlm.nih.gov/18983140 DM6YD3U DI DM6YD3U DM6YD3U DN 6-fluorotryptophan DM6YD3U MI TT3KLDP DM6YD3U MN L-Tryptophan hydroxylase 2 (TPH2) DM6YD3U MT DTT DM6YD3U MA Inhibitor DM6YD3U RN (+)-6-fluorotryptophan, an inhibitor of tryptophan hydroxylase: sleep and wakefulness in the rat. Neuropharmacology. 1981 Apr;20(4):335-9. DM6YD3U RU https://pubmed.ncbi.nlm.nih.gov/6457252 DM6YD3U DI DM6YD3U DM6YD3U DN 6-fluorotryptophan DM6YD3U MI TTZSJHV DM6YD3U MN Tryptophan 5-hydroxylase 1 (TPH1) DM6YD3U MT DTT DM6YD3U MA Inhibitor DM6YD3U RN (+)-6-fluorotryptophan, an inhibitor of tryptophan hydroxylase: sleep and wakefulness in the rat. Neuropharmacology. 1981 Apr;20(4):335-9. DM6YD3U RU https://pubmed.ncbi.nlm.nih.gov/6457252 DMN84RM DI DMN84RM DMN84RM DN 6-Formylindolo[3,2-b]carbazole DMN84RM MI TT037IE DMN84RM MN Aryl hydrocarbon receptor (AHR) DMN84RM MT DTT DMN84RM MA Agonist DMN84RM RN 6-Formylindolo(3,2-b)carbazole induced aryl hydrocarbon receptor activation prevents intestinal barrier dysfunction through regulation of claudin-2 expression. Chem Biol Interact. 2018 May 25;288:83-90. DMN84RM RU https://pubmed.ncbi.nlm.nih.gov/29680209 DMOLIW4 DI DMOLIW4 DMOLIW4 DN 6-Furan-2-yl-9-phenethyl-9H-purin-2-ylamine DMOLIW4 MI TTM2AOE DMOLIW4 MN Adenosine A2a receptor (ADORA2A) DMOLIW4 MT DTT DMOLIW4 MA Inhibitor DMOLIW4 RN 6-(2-Furanyl)-9H-purin-2-amine derivatives as A2A adenosine antagonists. Bioorg Med Chem Lett. 2005 Apr 15;15(8):2119-22. DMOLIW4 RU https://pubmed.ncbi.nlm.nih.gov/15808481 DMSJP6T DI DMSJP6T DMSJP6T DN 6-Furan-2-yl-9-phenyl-9H-purin-2-ylamine DMSJP6T MI TTM2AOE DMSJP6T MN Adenosine A2a receptor (ADORA2A) DMSJP6T MT DTT DMSJP6T MA Inhibitor DMSJP6T RN 6-(2-Furanyl)-9H-purin-2-amine derivatives as A2A adenosine antagonists. Bioorg Med Chem Lett. 2005 Apr 15;15(8):2119-22. DMSJP6T RU https://pubmed.ncbi.nlm.nih.gov/15808481 DMM86PK DI DMM86PK DMM86PK DN 6-guanidino-2-(3''-indolylethyloxy)adenosine DMM86PK MI TTK25J1 DMM86PK MN Adenosine A1 receptor (ADORA1) DMM86PK MT DTT DMM86PK MA Inhibitor DMM86PK RN Structure-activity relationships of 2,N(6),5'-substituted adenosine derivatives with potent activity at the A2B adenosine receptor. J Med Chem. 2007 Apr 19;50(8):1810-27. DMM86PK RU https://pubmed.ncbi.nlm.nih.gov/17378544 DMM86PK DI DMM86PK DMM86PK DN 6-guanidino-2-(3''-indolylethyloxy)adenosine DMM86PK MI TTM2AOE DMM86PK MN Adenosine A2a receptor (ADORA2A) DMM86PK MT DTT DMM86PK MA Inhibitor DMM86PK RN Structure-activity relationships of 2,N(6),5'-substituted adenosine derivatives with potent activity at the A2B adenosine receptor. J Med Chem. 2007 Apr 19;50(8):1810-27. DMM86PK RU https://pubmed.ncbi.nlm.nih.gov/17378544 DMM86PK DI DMM86PK DMM86PK DN 6-guanidino-2-(3''-indolylethyloxy)adenosine DMM86PK MI TTJFY5U DMM86PK MN Adenosine A3 receptor (ADORA3) DMM86PK MT DTT DMM86PK MA Inhibitor DMM86PK RN Structure-activity relationships of 2,N(6),5'-substituted adenosine derivatives with potent activity at the A2B adenosine receptor. J Med Chem. 2007 Apr 19;50(8):1810-27. DMM86PK RU https://pubmed.ncbi.nlm.nih.gov/17378544 DMF3W15 DI DMF3W15 DMF3W15 DN 6-Heptyl-4-hydroxy-3-octanoyl-pyran-2-one DMF3W15 MI TTPLTSQ DMF3W15 MN Neutrophil elastase (NE) DMF3W15 MT DTT DMF3W15 MA Inhibitor DMF3W15 RN Inhibition of human sputum elastase by substituted 2-pyrones. J Med Chem. 1987 Jun;30(6):1017-23. DMF3W15 RU https://pubmed.ncbi.nlm.nih.gov/3647139 DMWLN2Y DI DMWLN2Y DMWLN2Y DN 6-hydroxy-1,2,9-trimethyl-9H-beta-carbolin-2-ium DMWLN2Y MI TT1RS9F DMWLN2Y MN Acetylcholinesterase (AChE) DMWLN2Y MT DTT DMWLN2Y MA Inhibitor DMWLN2Y RN 6-Hydroxy- and 6-methoxy-beta-carbolines as acetyl- and butyrylcholinesterase inhibitors. Bioorg Med Chem Lett. 2006 Nov 15;16(22):5840-3. DMWLN2Y RU https://pubmed.ncbi.nlm.nih.gov/16945529 DMWLN2Y DI DMWLN2Y DMWLN2Y DN 6-hydroxy-1,2,9-trimethyl-9H-beta-carbolin-2-ium DMWLN2Y MI TTEB0GD DMWLN2Y MN Cholinesterase (BCHE) DMWLN2Y MT DTT DMWLN2Y MA Inhibitor DMWLN2Y RN 6-Hydroxy- and 6-methoxy-beta-carbolines as acetyl- and butyrylcholinesterase inhibitors. Bioorg Med Chem Lett. 2006 Nov 15;16(22):5840-3. DMWLN2Y RU https://pubmed.ncbi.nlm.nih.gov/16945529 DM20DAG DI DM20DAG DM20DAG DN 6-hydroxy-1,2-dimethyl-9H-beta-carbolin-2-ium DM20DAG MI TT1RS9F DM20DAG MN Acetylcholinesterase (AChE) DM20DAG MT DTT DM20DAG MA Inhibitor DM20DAG RN 6-Hydroxy- and 6-methoxy-beta-carbolines as acetyl- and butyrylcholinesterase inhibitors. Bioorg Med Chem Lett. 2006 Nov 15;16(22):5840-3. DM20DAG RU https://pubmed.ncbi.nlm.nih.gov/16945529 DM20DAG DI DM20DAG DM20DAG DN 6-hydroxy-1,2-dimethyl-9H-beta-carbolin-2-ium DM20DAG MI TTEB0GD DM20DAG MN Cholinesterase (BCHE) DM20DAG MT DTT DM20DAG MA Inhibitor DM20DAG RN 6-Hydroxy- and 6-methoxy-beta-carbolines as acetyl- and butyrylcholinesterase inhibitors. Bioorg Med Chem Lett. 2006 Nov 15;16(22):5840-3. DM20DAG RU https://pubmed.ncbi.nlm.nih.gov/16945529 DMPSOIF DI DMPSOIF DMPSOIF DN 6-HYDROXY-1,3-BENZOTHIAZOLE-2-SULFONAMIDE DMPSOIF MI TTANPDJ DMPSOIF MN Carbonic anhydrase II (CA-II) DMPSOIF MT DTT DMPSOIF MA Inhibitor DMPSOIF RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DMPSOIF RU https://pubmed.ncbi.nlm.nih.gov/10592235 DMPSOIF DI DMPSOIF DMPSOIF DN 6-HYDROXY-1,3-BENZOTHIAZOLE-2-SULFONAMIDE DMPSOIF MI TT2AST1 DMPSOIF MN Macrophage migration inhibitory factor (MIF) DMPSOIF MT DTT DMPSOIF MA Inhibitor DMPSOIF RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DMPSOIF RU https://pubmed.ncbi.nlm.nih.gov/10592235 DMUD1CG DI DMUD1CG DMUD1CG DN 6-Hydroxy-1,6-Dihydro Purine Nucleoside DMUD1CG MI TTLP57V DMUD1CG MN Adenosine deaminase (ADA) DMUD1CG MT DTT DMUD1CG MA Inhibitor DMUD1CG RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMUD1CG RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMU1CGD DI DMU1CGD DMU1CGD DN 6-Hydroxy-2-(4-hydroxy-benzyl)-chromen-4-one DMU1CGD MI TTFBNVI DMU1CGD MN Aldose reductase (AKR1B1) DMU1CGD MT DTT DMU1CGD MA Inhibitor DMU1CGD RN 1-Benzopyran-4-one antioxidants as aldose reductase inhibitors. J Med Chem. 1999 Jun 3;42(11):1881-93. DMU1CGD RU https://pubmed.ncbi.nlm.nih.gov/10354396 DMNA2M6 DI DMNA2M6 DMNA2M6 DN 6-hydroxy-2,9-dimethyl-9H-beta-carbolin-2-ium DMNA2M6 MI TT1RS9F DMNA2M6 MN Acetylcholinesterase (AChE) DMNA2M6 MT DTT DMNA2M6 MA Inhibitor DMNA2M6 RN 6-Hydroxy- and 6-methoxy-beta-carbolines as acetyl- and butyrylcholinesterase inhibitors. Bioorg Med Chem Lett. 2006 Nov 15;16(22):5840-3. DMNA2M6 RU https://pubmed.ncbi.nlm.nih.gov/16945529 DMAK35M DI DMAK35M DMAK35M DN 6-hydroxy-2-methyl-9H-beta-carbolin-2-ium DMAK35M MI TT1RS9F DMAK35M MN Acetylcholinesterase (AChE) DMAK35M MT DTT DMAK35M MA Inhibitor DMAK35M RN 6-Hydroxy- and 6-methoxy-beta-carbolines as acetyl- and butyrylcholinesterase inhibitors. Bioorg Med Chem Lett. 2006 Nov 15;16(22):5840-3. DMAK35M RU https://pubmed.ncbi.nlm.nih.gov/16945529 DMAK35M DI DMAK35M DMAK35M DN 6-hydroxy-2-methyl-9H-beta-carbolin-2-ium DMAK35M MI TTEB0GD DMAK35M MN Cholinesterase (BCHE) DMAK35M MT DTT DMAK35M MA Inhibitor DMAK35M RN 6-Hydroxy- and 6-methoxy-beta-carbolines as acetyl- and butyrylcholinesterase inhibitors. Bioorg Med Chem Lett. 2006 Nov 15;16(22):5840-3. DMAK35M RU https://pubmed.ncbi.nlm.nih.gov/16945529 DM4F5OG DI DM4F5OG DM4F5OG DN 6-hydroxy-3-(3',5'-dihydroxyphenyl)coumarin DM4F5OG MI TT34BHT DM4F5OG MN Adrenergic receptor alpha-1D (ADRA1D) DM4F5OG MT DTT DM4F5OG MA Inhibitor DM4F5OG RN Design, synthesis, and vasorelaxant and platelet antiaggregatory activities of coumarin-resveratrol hybrids. Bioorg Med Chem Lett. 2006 Jan 15;16(2):257-61. DM4F5OG RU https://pubmed.ncbi.nlm.nih.gov/16275073 DM0CVTI DI DM0CVTI DM0CVTI DN 6-Hydroxy-5,7-dimethyl-beta-carboline DM0CVTI MI TTJFY5U DM0CVTI MN Adenosine A3 receptor (ADORA3) DM0CVTI MT DTT DM0CVTI MA Inhibitor DM0CVTI RN Synthesis of eudistomin D analogues and its effects on adenosine receptors. Bioorg Med Chem. 2008 Apr 1;16(7):3825-30. DM0CVTI RU https://pubmed.ncbi.nlm.nih.gov/18262425 DMNM1EZ DI DMNM1EZ DMNM1EZ DN 6-Hydroxy-7,8-Dihydro Purine Nucleoside DMNM1EZ MI TTLP57V DMNM1EZ MN Adenosine deaminase (ADA) DMNM1EZ MT DTT DMNM1EZ MA Inhibitor DMNM1EZ RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMNM1EZ RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMPQTNK DI DMPQTNK DMPQTNK DN 6-hydroxy-7,9-octadecadiynoic acid DMPQTNK MI TTPADOQ DMPQTNK MN HMG-CoA reductase (HMGCR) DMPQTNK MT DTT DMPQTNK MA Inhibitor DMPQTNK RN Novel Acetylenic Acids from the Root Bark of Paramacrolobium caeruleum: Inhibitors of 3-Hydroxy-3-methyl-glutaryl Coenzyme A Reductase J. Nat. Prod. 52(1):153-161 (1989). DMPQTNK RU http://pubs.acs.org/doi/abs/10.1021/np50061a020 DMDRSNH DI DMDRSNH DMDRSNH DN 6-hydroxybenzo[d][1,3]oxathiol-2-one DMDRSNH MI TTANPDJ DMDRSNH MN Carbonic anhydrase II (CA-II) DMDRSNH MT DTT DMDRSNH MA Inhibitor DMDRSNH RN Carbonic anhydrase inhibitors: thioxolone versus sulfonamides for obtaining isozyme-selective inhibitors Bioorg Med Chem Lett. 2008 Jul 15;18(14):3938-41. DMDRSNH RU https://pubmed.ncbi.nlm.nih.gov/18572406 DM2B4S5 DI DM2B4S5 DM2B4S5 DN 6-Hydroxy-benzothiazole-2-sulfonic acid amide DM2B4S5 MI TTUNARX DM2B4S5 MN Carbonic anhydrase (CA) DM2B4S5 MT DTT DM2B4S5 MA Inhibitor DM2B4S5 RN Cloning, expression, post-translational modifications and inhibition studies on the latest mammalian carbonic anhydrase isoform, CA XV. J Med Chem. 2009 Feb 12;52(3):646-54. DM2B4S5 RU https://pubmed.ncbi.nlm.nih.gov/19193158 DM2B4S5 DI DM2B4S5 DM2B4S5 DN 6-Hydroxy-benzothiazole-2-sulfonic acid amide DM2B4S5 MI TTHQPL7 DM2B4S5 MN Carbonic anhydrase I (CA-I) DM2B4S5 MT DTT DM2B4S5 MA Inhibitor DM2B4S5 RN Cloning, expression, post-translational modifications and inhibition studies on the latest mammalian carbonic anhydrase isoform, CA XV. J Med Chem. 2009 Feb 12;52(3):646-54. DM2B4S5 RU https://pubmed.ncbi.nlm.nih.gov/19193158 DM2B4S5 DI DM2B4S5 DM2B4S5 DN 6-Hydroxy-benzothiazole-2-sulfonic acid amide DM2B4S5 MI TTANPDJ DM2B4S5 MN Carbonic anhydrase II (CA-II) DM2B4S5 MT DTT DM2B4S5 MA Inhibitor DM2B4S5 RN Cloning, expression, post-translational modifications and inhibition studies on the latest mammalian carbonic anhydrase isoform, CA XV. J Med Chem. 2009 Feb 12;52(3):646-54. DM2B4S5 RU https://pubmed.ncbi.nlm.nih.gov/19193158 DM2B4S5 DI DM2B4S5 DM2B4S5 DN 6-Hydroxy-benzothiazole-2-sulfonic acid amide DM2B4S5 MI TT2LVK8 DM2B4S5 MN Carbonic anhydrase IX (CA-IX) DM2B4S5 MT DTT DM2B4S5 MA Inhibitor DM2B4S5 RN Cloning, expression, post-translational modifications and inhibition studies on the latest mammalian carbonic anhydrase isoform, CA XV. J Med Chem. 2009 Feb 12;52(3):646-54. DM2B4S5 RU https://pubmed.ncbi.nlm.nih.gov/19193158 DM2B4S5 DI DM2B4S5 DM2B4S5 DN 6-Hydroxy-benzothiazole-2-sulfonic acid amide DM2B4S5 MI TTCFSPE DM2B4S5 MN Carbonic anhydrase VI (CA-VI) DM2B4S5 MT DTT DM2B4S5 MA Inhibitor DM2B4S5 RN Cloning, expression, post-translational modifications and inhibition studies on the latest mammalian carbonic anhydrase isoform, CA XV. J Med Chem. 2009 Feb 12;52(3):646-54. DM2B4S5 RU https://pubmed.ncbi.nlm.nih.gov/19193158 DM2B4S5 DI DM2B4S5 DM2B4S5 DN 6-Hydroxy-benzothiazole-2-sulfonic acid amide DM2B4S5 MI TTSYM0R DM2B4S5 MN Carbonic anhydrase XII (CA-XII) DM2B4S5 MT DTT DM2B4S5 MA Inhibitor DM2B4S5 RN Carbonic anhydrase inhibitors. Inhibition of the transmembrane isozyme XII with sulfonamides-a new target for the design of antitumor and antiglauc... Bioorg Med Chem Lett. 2005 Feb 15;15(4):963-9. DM2B4S5 RU https://pubmed.ncbi.nlm.nih.gov/15686894 DM2B4S5 DI DM2B4S5 DM2B4S5 DN 6-Hydroxy-benzothiazole-2-sulfonic acid amide DM2B4S5 MI TTEYTKG DM2B4S5 MN Carbonic anhydrase XIV (CA-XIV) DM2B4S5 MT DTT DM2B4S5 MA Inhibitor DM2B4S5 RN Carbonic anhydrase inhibitors: inhibition of the transmembrane isozyme XIV with sulfonamides. Bioorg Med Chem Lett. 2005 Sep 1;15(17):3828-33. DM2B4S5 RU https://pubmed.ncbi.nlm.nih.gov/16039848 DM7M58P DI DM7M58P DM7M58P DN 6-hydroxydopa quinone DM7M58P MI TT7HC21 DM7M58P MN Membrane copper amine oxidase (AOC3) DM7M58P MT DTT DM7M58P MA Inhibitor DM7M58P RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DM7M58P RU https://pubmed.ncbi.nlm.nih.gov/17139284 DM6FNVC DI DM6FNVC DM6FNVC DN 6-Hydroxyflavanone DM6FNVC MI TTKPW01 DM6FNVC MN Androgen receptor messenger RNA (AR mRNA) DM6FNVC MT DTT DM6FNVC MA Inhibitor DM6FNVC RN Effect of flavonoids on androgen and glucocorticoid receptors based on in vitro reporter gene assay. Bioorg Med Chem Lett. 2009 Aug 15;19(16):4706-10. DM6FNVC RU https://pubmed.ncbi.nlm.nih.gov/19592245 DM89YV7 DI DM89YV7 DM89YV7 DN 6-hydroxymelatonin DM89YV7 MI TT0WAIE DM89YV7 MN Melatonin receptor type 1A (MTNR1A) DM89YV7 MT DTT DM89YV7 MA Agonist DM89YV7 RN Characterization of a retinal melatonin receptor. J Pharmacol Exp Ther. 1985 Aug;234(2):395-401. DM89YV7 RU https://pubmed.ncbi.nlm.nih.gov/2991499 DMYF60K DI DMYF60K DMYF60K DN 6-Hydroxymethyl-7,8-Dihydropterin DMYF60K MI TTG9CFY DMYF60K MN Bacterial Dihydroneopterinaldolase (Bact folB) DMYF60K MT DTT DMYF60K MA Inhibitor DMYF60K RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMYF60K RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMYF60K DI DMYF60K DMYF60K DN 6-Hydroxymethyl-7,8-Dihydropterin DMYF60K MI TT38ECI DMYF60K MN Bacterial Hydroxymethyl-dihydropterin pyrophosphokinase (Bact folK) DMYF60K MT DTT DMYF60K MA Inhibitor DMYF60K RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMYF60K RU https://pubmed.ncbi.nlm.nih.gov/17139284 DM7EWDN DI DM7EWDN DM7EWDN DN 6-Hydroxymethylpterin DM7EWDN MI TT38ECI DM7EWDN MN Bacterial Hydroxymethyl-dihydropterin pyrophosphokinase (Bact folK) DM7EWDN MT DTT DM7EWDN MA Inhibitor DM7EWDN RN DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Nucleic Acids Res. 2011 Jan;39(Database issue):D1035-41. DM7EWDN RU https://pubmed.ncbi.nlm.nih.gov/21059682 DM6KVO0 DI DM6KVO0 DM6KVO0 DN 6-Hydroxy-N-(2-morpholinoethyl)nicotinamide DM6KVO0 MI TT3WG5C DM6KVO0 MN Monoamine oxidase type A (MAO-A) DM6KVO0 MT DTT DM6KVO0 MA Inhibitor DM6KVO0 RN Design of novel nicotinamides as potent and selective monoamine oxidase a inhibitors. Bioorg Med Chem. 2010 Feb 15;18(4):1659-64. DM6KVO0 RU https://pubmed.ncbi.nlm.nih.gov/20117937 DMVRFU5 DI DMVRFU5 DMVRFU5 DN 6-Hydroxypropylthymine DMVRFU5 MI TTP3QRF DMVRFU5 MN Thymidine kinase 1 (TK1) DMVRFU5 MT DTT DMVRFU5 MA Inhibitor DMVRFU5 RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMVRFU5 RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMDMNQV DI DMDMNQV DMDMNQV DN 6-Hydroxyuridine-5'-Phosphate DMDMNQV MI TTV7Y40 DMDMNQV MN Mycobacterium Orotidine phosphate decarboxylase (MycB pyrF) DMDMNQV MT DTT DMDMNQV MA Inhibitor DMDMNQV RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMDMNQV RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMDMNQV DI DMDMNQV DMDMNQV DN 6-Hydroxyuridine-5'-Phosphate DMDMNQV MI TTAFJUD DMDMNQV MN Orotidine 5'-monophosphate decarboxylase (UMPS) DMDMNQV MT DTT DMDMNQV MA Inhibitor DMDMNQV RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMDMNQV RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMQF8JG DI DMQF8JG DMQF8JG DN 6-ile-ustiloxin DMQF8JG MI TTYFKSZ DMQF8JG MN Tubulin beta (TUBB) DMQF8JG MT DTT DMQF8JG MA Inhibitor DMQF8JG RN Total synthesis and biological evaluation of ustiloxin natural products and two analogs. Bioorg Med Chem Lett. 2006 Sep 15;16(18):4804-7. DMQF8JG RU https://pubmed.ncbi.nlm.nih.gov/16837194 DMQF8JG DI DMQF8JG DMQF8JG DN 6-ile-ustiloxin DMQF8JG MI TTJ2PTI DMQF8JG MN Tubulin beta-2 chain (TUBB2) DMQF8JG MT DTT DMQF8JG MA Inhibitor DMQF8JG RN Total synthesis and biological evaluation of ustiloxin natural products and two analogs. Bioorg Med Chem Lett. 2006 Sep 15;16(18):4804-7. DMQF8JG RU https://pubmed.ncbi.nlm.nih.gov/16837194 DMRMSU5 DI DMRMSU5 DMRMSU5 DN 6-Imidazol-1-yl-3,4-dihydro-1H-quinolin-2-one DMRMSU5 MI TT06AWU DMRMSU5 MN Phosphodiesterase 3A (PDE3A) DMRMSU5 MT DTT DMRMSU5 MA Inhibitor DMRMSU5 RN 3,4-Dihydroquinolin-2(1H)-ones as combined inhibitors of thromboxane A2 synthase and cAMP phosphodiesterase. J Med Chem. 1992 Feb 21;35(4):620-8. DMRMSU5 RU https://pubmed.ncbi.nlm.nih.gov/1311763 DMQXL1Y DI DMQXL1Y DMQXL1Y DN 6-Imidazol-1-yl-isoquinoline DMQXL1Y MI TTSZLWK DMQXL1Y MN Aromatase (CYP19A1) DMQXL1Y MT DTT DMQXL1Y MA Inhibitor DMQXL1Y RN Fast three dimensional pharmacophore virtual screening of new potent non-steroid aromatase inhibitors. J Med Chem. 2009 Jan 8;52(1):143-50. DMQXL1Y RU https://pubmed.ncbi.nlm.nih.gov/19072235 DMQXL1Y DI DMQXL1Y DMQXL1Y DN 6-Imidazol-1-yl-isoquinoline DMQXL1Y MI TTKNWZ4 DMQXL1Y MN Thromboxane-A synthase (TBXAS1) DMQXL1Y MT DTT DMQXL1Y MA Inhibitor DMQXL1Y RN 1-imidazolyl(alkyl)-substituted di- and tetrahydroquinolines and analogues: syntheses and evaluation of dual inhibitors of thromboxane A(2) synthas... J Med Chem. 2000 May 4;43(9):1841-51. DMQXL1Y RU https://pubmed.ncbi.nlm.nih.gov/10794700 DMBQ3HV DI DMBQ3HV DMBQ3HV DN 6-Imidazol-1-ylmethyl-8-phenyl-quinoline DMBQ3HV MI TTZ97H5 DMBQ3HV MN Phosphodiesterase 4A (PDE4A) DMBQ3HV MT DTT DMBQ3HV MA Inhibitor DMBQ3HV RN Hunting the emesis and efficacy targets of PDE4 inhibitors: identification of the photoaffinity probe 8-(3-azidophenyl)-6- [(4-iodo-1H-1-imidazolyl... J Med Chem. 2000 Oct 19;43(21):3820-3. DMBQ3HV RU https://pubmed.ncbi.nlm.nih.gov/11052785 DM31VLA DI DM31VLA DM31VLA DN 6-Iodo-2-piperazin-1-yl-quinoline DM31VLA MI TT3ROYC DM31VLA MN Serotonin transporter (SERT) DM31VLA MT DTT DM31VLA MA Inhibitor DM31VLA RN Syntheses and binding affinities of 6-nitroquipazine analogues for serotonin transporter. Part 1. Bioorg Med Chem Lett. 2000 Jul 17;10(14):1559-62. DM31VLA RU https://pubmed.ncbi.nlm.nih.gov/10915050 DMAL1UH DI DMAL1UH DMAL1UH DN 6-iodo-4'-dimethyaminoflavone DMAL1UH MI TTE4KHA DMAL1UH MN Amyloid beta A4 protein (APP) DMAL1UH MT DTT DMAL1UH MA Inhibitor DMAL1UH RN Radioiodinated flavones for in vivo imaging of beta-amyloid plaques in the brain. J Med Chem. 2005 Nov 17;48(23):7253-60. DMAL1UH RU https://pubmed.ncbi.nlm.nih.gov/16279784 DM5FZBI DI DM5FZBI DM5FZBI DN 6-iodo-4'-hydroxyflavone DM5FZBI MI TTE4KHA DM5FZBI MN Amyloid beta A4 protein (APP) DM5FZBI MT DTT DM5FZBI MA Inhibitor DM5FZBI RN Radioiodinated flavones for in vivo imaging of beta-amyloid plaques in the brain. J Med Chem. 2005 Nov 17;48(23):7253-60. DM5FZBI RU https://pubmed.ncbi.nlm.nih.gov/16279784 DM6U9CY DI DM6U9CY DM6U9CY DN 6-iodo-4'-methoxyflavone DM6U9CY MI TTE4KHA DM6U9CY MN Amyloid beta A4 protein (APP) DM6U9CY MT DTT DM6U9CY MA Inhibitor DM6U9CY RN Radioiodinated flavones for in vivo imaging of beta-amyloid plaques in the brain. J Med Chem. 2005 Nov 17;48(23):7253-60. DM6U9CY RU https://pubmed.ncbi.nlm.nih.gov/16279784 DM9GJAY DI DM9GJAY DM9GJAY DN 6-iodo-4'-methylaminoflavone DM9GJAY MI TTE4KHA DM9GJAY MN Amyloid beta A4 protein (APP) DM9GJAY MT DTT DM9GJAY MA Inhibitor DM9GJAY RN Radioiodinated flavones for in vivo imaging of beta-amyloid plaques in the brain. J Med Chem. 2005 Nov 17;48(23):7253-60. DM9GJAY RU https://pubmed.ncbi.nlm.nih.gov/16279784 DM0GSRL DI DM0GSRL DM0GSRL DN 6'-Iodononivamide DM0GSRL MI TTMI6F5 DM0GSRL MN Transient receptor potential cation channel V1 (TRPV1) DM0GSRL MT DTT DM0GSRL MA Inhibitor DM0GSRL RN Halogenation of 4-hydroxy/amino-3-methoxyphenyl acetamide TRPV1 agonists showed enhanced antagonism to capsaicin. Bioorg Med Chem. 2010 Nov 15;18(22):8092-105. DM0GSRL RU https://pubmed.ncbi.nlm.nih.gov/20937561 DM1S9DB DI DM1S9DB DM1S9DB DN 6-iodo-nordihydrocapsaicin DM1S9DB MI TTMI6F5 DM1S9DB MN Transient receptor potential cation channel V1 (TRPV1) DM1S9DB MT DTT DM1S9DB MA Blocker (channel blocker) DM1S9DB RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 507). DM1S9DB RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=507 DM2XB68 DI DM2XB68 DM2XB68 DN 6-isobutyl-4-methylpyridin-2-amine DM2XB68 MI TTZUFI5 DM2XB68 MN Nitric-oxide synthase brain (NOS1) DM2XB68 MT DTT DM2XB68 MA Inhibitor DM2XB68 RN Design and synthesis of 2-amino-4-methylpyridine analogues as inhibitors for inducible nitric oxide synthase and in vivo evaluation of [18F]6-(2-fl... J Med Chem. 2009 Apr 23;52(8):2443-53. DM2XB68 RU https://pubmed.ncbi.nlm.nih.gov/19323559 DM2XB68 DI DM2XB68 DM2XB68 DN 6-isobutyl-4-methylpyridin-2-amine DM2XB68 MI TTCM4B3 DM2XB68 MN Nitric-oxide synthase endothelial (NOS3) DM2XB68 MT DTT DM2XB68 MA Inhibitor DM2XB68 RN Design and synthesis of 2-amino-4-methylpyridine analogues as inhibitors for inducible nitric oxide synthase and in vivo evaluation of [18F]6-(2-fl... J Med Chem. 2009 Apr 23;52(8):2443-53. DM2XB68 RU https://pubmed.ncbi.nlm.nih.gov/19323559 DM2XB68 DI DM2XB68 DM2XB68 DN 6-isobutyl-4-methylpyridin-2-amine DM2XB68 MI TTF10I9 DM2XB68 MN Nitric-oxide synthase inducible (NOS2) DM2XB68 MT DTT DM2XB68 MA Inhibitor DM2XB68 RN Design and synthesis of 2-amino-4-methylpyridine analogues as inhibitors for inducible nitric oxide synthase and in vivo evaluation of [18F]6-(2-fl... J Med Chem. 2009 Apr 23;52(8):2443-53. DM2XB68 RU https://pubmed.ncbi.nlm.nih.gov/19323559 DMGXMZL DI DMGXMZL DMGXMZL DN 6-isopropyl-2-morpholin-4-yl-4H-thiopyran-4-one DMGXMZL MI TTK3PY9 DMGXMZL MN DNA-dependent protein kinase catalytic (PRKDC) DMGXMZL MT DTT DMGXMZL MA Inhibitor DMGXMZL RN Pyranone, thiopyranone, and pyridone inhibitors of phosphatidylinositol 3-kinase related kinases. Structure-activity relationships for DNA-dependen... J Med Chem. 2007 Apr 19;50(8):1958-72. DMGXMZL RU https://pubmed.ncbi.nlm.nih.gov/17371003 DMO2F8L DI DMO2F8L DMO2F8L DN 6-Isopropyl-2-phenyl-chromen-4-one DMO2F8L MI TTNJYV2 DMO2F8L MN Gamma-aminobutyric acid receptor (GAR) DMO2F8L MT DTT DMO2F8L MA Inhibitor DMO2F8L RN Refinement and evaluation of a pharmacophore model for flavone derivatives binding to the benzodiazepine site of the GABA(A) receptor. J Med Chem. 2002 Sep 12;45(19):4188-201. DMO2F8L RU https://pubmed.ncbi.nlm.nih.gov/12213060 DM2WUZP DI DM2WUZP DM2WUZP DN 6-Isoquinolin-4-yl-3,4-dihydroquinolin-2(1H)-one DM2WUZP MI TTIQUX7 DM2WUZP MN Steroid 11-beta-hydroxylase (CYP11B1) DM2WUZP MT DTT DM2WUZP MA Inhibitor DM2WUZP RN In vivo active aldosterone synthase inhibitors with improved selectivity: lead optimization providing a series of pyridine substituted 3,4-dihydro-... J Med Chem. 2008 Dec 25;51(24):8077-87. DM2WUZP RU https://pubmed.ncbi.nlm.nih.gov/19049427 DMD2FW9 DI DMD2FW9 DMD2FW9 DN 6-Mercapto-hexanoic acid phenylamide DMD2FW9 MI TTBH0VX DMD2FW9 MN Histone deacetylase (HDAC) DMD2FW9 MT DTT DMD2FW9 MA Inhibitor DMD2FW9 RN Novel inhibitors of human histone deacetylases: design, synthesis, enzyme inhibition, and cancer cell growth inhibition of SAHA-based non-hydroxama... J Med Chem. 2005 Feb 24;48(4):1019-32. DMD2FW9 RU https://pubmed.ncbi.nlm.nih.gov/15715470 DMD2FW9 DI DMD2FW9 DMD2FW9 DN 6-Mercapto-hexanoic acid phenylamide DMD2FW9 MI TT6R7JZ DMD2FW9 MN Histone deacetylase 1 (HDAC1) DMD2FW9 MT DTT DMD2FW9 MA Inhibitor DMD2FW9 RN Novel inhibitors of human histone deacetylases: design, synthesis, enzyme inhibition, and cancer cell growth inhibition of SAHA-based non-hydroxama... J Med Chem. 2005 Feb 24;48(4):1019-32. DMD2FW9 RU https://pubmed.ncbi.nlm.nih.gov/15715470 DMD2FW9 DI DMD2FW9 DMD2FW9 DN 6-Mercapto-hexanoic acid phenylamide DMD2FW9 MI TTYHPU6 DMD2FW9 MN Histone deacetylase 10 (HDAC10) DMD2FW9 MT DTT DMD2FW9 MA Inhibitor DMD2FW9 RN Novel inhibitors of human histone deacetylases: design, synthesis, enzyme inhibition, and cancer cell growth inhibition of SAHA-based non-hydroxama... J Med Chem. 2005 Feb 24;48(4):1019-32. DMD2FW9 RU https://pubmed.ncbi.nlm.nih.gov/15715470 DMD2FW9 DI DMD2FW9 DMD2FW9 DN 6-Mercapto-hexanoic acid phenylamide DMD2FW9 MI TTSHTOI DMD2FW9 MN Histone deacetylase 2 (HDAC2) DMD2FW9 MT DTT DMD2FW9 MA Inhibitor DMD2FW9 RN Novel inhibitors of human histone deacetylases: design, synthesis, enzyme inhibition, and cancer cell growth inhibition of SAHA-based non-hydroxama... J Med Chem. 2005 Feb 24;48(4):1019-32. DMD2FW9 RU https://pubmed.ncbi.nlm.nih.gov/15715470 DMD2FW9 DI DMD2FW9 DMD2FW9 DN 6-Mercapto-hexanoic acid phenylamide DMD2FW9 MI TTTQGH8 DMD2FW9 MN Histone deacetylase 4 (HDAC4) DMD2FW9 MT DTT DMD2FW9 MA Inhibitor DMD2FW9 RN Novel inhibitors of human histone deacetylases: design, synthesis, enzyme inhibition, and cancer cell growth inhibition of SAHA-based non-hydroxama... J Med Chem. 2005 Feb 24;48(4):1019-32. DMD2FW9 RU https://pubmed.ncbi.nlm.nih.gov/15715470 DMD2FW9 DI DMD2FW9 DMD2FW9 DN 6-Mercapto-hexanoic acid phenylamide DMD2FW9 MI TT5ZKDI DMD2FW9 MN Histone deacetylase 6 (HDAC6) DMD2FW9 MT DTT DMD2FW9 MA Inhibitor DMD2FW9 RN Novel inhibitors of human histone deacetylases: design, synthesis, enzyme inhibition, and cancer cell growth inhibition of SAHA-based non-hydroxama... J Med Chem. 2005 Feb 24;48(4):1019-32. DMD2FW9 RU https://pubmed.ncbi.nlm.nih.gov/15715470 DMD2FW9 DI DMD2FW9 DMD2FW9 DN 6-Mercapto-hexanoic acid phenylamide DMD2FW9 MI TTT6LFV DMD2FW9 MN Histone deacetylase 8 (HDAC8) DMD2FW9 MT DTT DMD2FW9 MA Inhibitor DMD2FW9 RN Novel inhibitors of human histone deacetylases: design, synthesis, enzyme inhibition, and cancer cell growth inhibition of SAHA-based non-hydroxama... J Med Chem. 2005 Feb 24;48(4):1019-32. DMD2FW9 RU https://pubmed.ncbi.nlm.nih.gov/15715470 DMJUT70 DI DMJUT70 DMJUT70 DN 6-methoxy-1,2-dimethyl-9H-beta-carbolin-2-ium DMJUT70 MI TT1RS9F DMJUT70 MN Acetylcholinesterase (AChE) DMJUT70 MT DTT DMJUT70 MA Inhibitor DMJUT70 RN 6-Hydroxy- and 6-methoxy-beta-carbolines as acetyl- and butyrylcholinesterase inhibitors. Bioorg Med Chem Lett. 2006 Nov 15;16(22):5840-3. DMJUT70 RU https://pubmed.ncbi.nlm.nih.gov/16945529 DMJUT70 DI DMJUT70 DMJUT70 DN 6-methoxy-1,2-dimethyl-9H-beta-carbolin-2-ium DMJUT70 MI TTEB0GD DMJUT70 MN Cholinesterase (BCHE) DMJUT70 MT DTT DMJUT70 MA Inhibitor DMJUT70 RN 6-Hydroxy- and 6-methoxy-beta-carbolines as acetyl- and butyrylcholinesterase inhibitors. Bioorg Med Chem Lett. 2006 Nov 15;16(22):5840-3. DMJUT70 RU https://pubmed.ncbi.nlm.nih.gov/16945529 DMOHWPD DI DMOHWPD DMOHWPD DN 6-methoxy-1,9-dimethyl-9H-pyrido[3,4-b]indole DMOHWPD MI TT1RS9F DMOHWPD MN Acetylcholinesterase (AChE) DMOHWPD MT DTT DMOHWPD MA Inhibitor DMOHWPD RN 6-Hydroxy- and 6-methoxy-beta-carbolines as acetyl- and butyrylcholinesterase inhibitors. Bioorg Med Chem Lett. 2006 Nov 15;16(22):5840-3. DMOHWPD RU https://pubmed.ncbi.nlm.nih.gov/16945529 DMOHWPD DI DMOHWPD DMOHWPD DN 6-methoxy-1,9-dimethyl-9H-pyrido[3,4-b]indole DMOHWPD MI TTEB0GD DMOHWPD MN Cholinesterase (BCHE) DMOHWPD MT DTT DMOHWPD MA Inhibitor DMOHWPD RN 6-Hydroxy- and 6-methoxy-beta-carbolines as acetyl- and butyrylcholinesterase inhibitors. Bioorg Med Chem Lett. 2006 Nov 15;16(22):5840-3. DMOHWPD RU https://pubmed.ncbi.nlm.nih.gov/16945529 DMZP3XJ DI DMZP3XJ DMZP3XJ DN 6-Methoxy-2-(4-phenoxy-benzyl)-1H-benzoimidazole DMZP3XJ MI TTLD29N DMZP3XJ MN Glutamate receptor ionotropic NMDA 1 (NMDAR1) DMZP3XJ MT DTT DMZP3XJ MA Inhibitor DMZP3XJ RN NR2B-selective N-methyl-D-aspartate antagonists: synthesis and evaluation of 5-substituted benzimidazoles. J Med Chem. 2004 Apr 8;47(8):2089-96. DMZP3XJ RU https://pubmed.ncbi.nlm.nih.gov/15056006 DMZP3XJ DI DMZP3XJ DMZP3XJ DN 6-Methoxy-2-(4-phenoxy-benzyl)-1H-benzoimidazole DMZP3XJ MI TTN9D8E DMZP3XJ MN Glutamate receptor ionotropic NMDA 2B (NMDAR2B) DMZP3XJ MT DTT DMZP3XJ MA Inhibitor DMZP3XJ RN NR2B-selective N-methyl-D-aspartate antagonists: synthesis and evaluation of 5-substituted benzimidazoles. J Med Chem. 2004 Apr 8;47(8):2089-96. DMZP3XJ RU https://pubmed.ncbi.nlm.nih.gov/15056006 DMSA367 DI DMSA367 DMSA367 DN 6-Methoxy-2,3,4,9-tetrahydro-1H-beta-carboline DMSA367 MI TTJQOD7 DMSA367 MN 5-HT 2A receptor (HTR2A) DMSA367 MT DTT DMSA367 MA Inhibitor DMSA367 RN Binding of beta-carbolines at 5-HT(2) serotonin receptors. Bioorg Med Chem Lett. 2003 Dec 15;13(24):4421-5. DMSA367 RU https://pubmed.ncbi.nlm.nih.gov/14643338 DMSA367 DI DMSA367 DMSA367 DN 6-Methoxy-2,3,4,9-tetrahydro-1H-beta-carboline DMSA367 MI TT3WG5C DMSA367 MN Monoamine oxidase type A (MAO-A) DMSA367 MT DTT DMSA367 MA Inhibitor DMSA367 RN Pyrazino[1,2-a]indoles as novel high-affinity and selective imidazoline I(2) receptor ligands. Bioorg Med Chem Lett. 2004 Feb 23;14(4):1003-5. DMSA367 RU https://pubmed.ncbi.nlm.nih.gov/15013010 DMSA367 DI DMSA367 DMSA367 DN 6-Methoxy-2,3,4,9-tetrahydro-1H-beta-carboline DMSA367 MI TTGP7BY DMSA367 MN Monoamine oxidase type B (MAO-B) DMSA367 MT DTT DMSA367 MA Inhibitor DMSA367 RN Pyrazino[1,2-a]indoles as novel high-affinity and selective imidazoline I(2) receptor ligands. Bioorg Med Chem Lett. 2004 Feb 23;14(4):1003-5. DMSA367 RU https://pubmed.ncbi.nlm.nih.gov/15013010 DMG3F7D DI DMG3F7D DMG3F7D DN 6-methoxy-2,9-dimethyl-9H-beta-carbolin-2-ium DMG3F7D MI TT1RS9F DMG3F7D MN Acetylcholinesterase (AChE) DMG3F7D MT DTT DMG3F7D MA Inhibitor DMG3F7D RN 6-Hydroxy- and 6-methoxy-beta-carbolines as acetyl- and butyrylcholinesterase inhibitors. Bioorg Med Chem Lett. 2006 Nov 15;16(22):5840-3. DMG3F7D RU https://pubmed.ncbi.nlm.nih.gov/16945529 DMHITF8 DI DMHITF8 DMHITF8 DN 6-methoxy-2-methyl-9H-beta-carbolin-2-ium DMHITF8 MI TT1RS9F DMHITF8 MN Acetylcholinesterase (AChE) DMHITF8 MT DTT DMHITF8 MA Inhibitor DMHITF8 RN 6-Hydroxy- and 6-methoxy-beta-carbolines as acetyl- and butyrylcholinesterase inhibitors. Bioorg Med Chem Lett. 2006 Nov 15;16(22):5840-3. DMHITF8 RU https://pubmed.ncbi.nlm.nih.gov/16945529 DMHITF8 DI DMHITF8 DMHITF8 DN 6-methoxy-2-methyl-9H-beta-carbolin-2-ium DMHITF8 MI TTEB0GD DMHITF8 MN Cholinesterase (BCHE) DMHITF8 MT DTT DMHITF8 MA Inhibitor DMHITF8 RN 6-Hydroxy- and 6-methoxy-beta-carbolines as acetyl- and butyrylcholinesterase inhibitors. Bioorg Med Chem Lett. 2006 Nov 15;16(22):5840-3. DMHITF8 RU https://pubmed.ncbi.nlm.nih.gov/16945529 DM7WH82 DI DM7WH82 DM7WH82 DN 6-methoxy-2-oxo-2H-chromene-3-carboxylic acid DM7WH82 MI TTUNARX DM7WH82 MN Carbonic anhydrase (CA) DM7WH82 MT DTT DM7WH82 MA Inhibitor DM7WH82 RN Deciphering the mechanism of carbonic anhydrase inhibition with coumarins and thiocoumarins. J Med Chem. 2010 Jan 14;53(1):335-44. DM7WH82 RU https://pubmed.ncbi.nlm.nih.gov/19911821 DM7WH82 DI DM7WH82 DM7WH82 DN 6-methoxy-2-oxo-2H-chromene-3-carboxylic acid DM7WH82 MI TTHQPL7 DM7WH82 MN Carbonic anhydrase I (CA-I) DM7WH82 MT DTT DM7WH82 MA Inhibitor DM7WH82 RN Deciphering the mechanism of carbonic anhydrase inhibition with coumarins and thiocoumarins. J Med Chem. 2010 Jan 14;53(1):335-44. DM7WH82 RU https://pubmed.ncbi.nlm.nih.gov/19911821 DM7WH82 DI DM7WH82 DM7WH82 DN 6-methoxy-2-oxo-2H-chromene-3-carboxylic acid DM7WH82 MI TTANPDJ DM7WH82 MN Carbonic anhydrase II (CA-II) DM7WH82 MT DTT DM7WH82 MA Inhibitor DM7WH82 RN Deciphering the mechanism of carbonic anhydrase inhibition with coumarins and thiocoumarins. J Med Chem. 2010 Jan 14;53(1):335-44. DM7WH82 RU https://pubmed.ncbi.nlm.nih.gov/19911821 DM7WH82 DI DM7WH82 DM7WH82 DN 6-methoxy-2-oxo-2H-chromene-3-carboxylic acid DM7WH82 MI TT2LVK8 DM7WH82 MN Carbonic anhydrase IX (CA-IX) DM7WH82 MT DTT DM7WH82 MA Inhibitor DM7WH82 RN Deciphering the mechanism of carbonic anhydrase inhibition with coumarins and thiocoumarins. J Med Chem. 2010 Jan 14;53(1):335-44. DM7WH82 RU https://pubmed.ncbi.nlm.nih.gov/19911821 DM7WH82 DI DM7WH82 DM7WH82 DN 6-methoxy-2-oxo-2H-chromene-3-carboxylic acid DM7WH82 MI TTSYM0R DM7WH82 MN Carbonic anhydrase XII (CA-XII) DM7WH82 MT DTT DM7WH82 MA Inhibitor DM7WH82 RN Deciphering the mechanism of carbonic anhydrase inhibition with coumarins and thiocoumarins. J Med Chem. 2010 Jan 14;53(1):335-44. DM7WH82 RU https://pubmed.ncbi.nlm.nih.gov/19911821 DM7WH82 DI DM7WH82 DM7WH82 DN 6-methoxy-2-oxo-2H-chromene-3-carboxylic acid DM7WH82 MI TTEYTKG DM7WH82 MN Carbonic anhydrase XIV (CA-XIV) DM7WH82 MT DTT DM7WH82 MA Inhibitor DM7WH82 RN Deciphering the mechanism of carbonic anhydrase inhibition with coumarins and thiocoumarins. J Med Chem. 2010 Jan 14;53(1):335-44. DM7WH82 RU https://pubmed.ncbi.nlm.nih.gov/19911821 DM52SDO DI DM52SDO DM52SDO DN 6-Methoxy-3-pyridin-4-yl-quinoline DM52SDO MI TT8FYO9 DM52SDO MN Platelet-derived growth factor receptor alpha (PDGFRA) DM52SDO MT DTT DM52SDO MA Inhibitor DM52SDO RN 5,7-Dimethoxy-3-(4-pyridinyl)quinoline is a potent and selective inhibitor of human vascular beta-type platelet-derived growth factor receptor tyro... J Med Chem. 1994 Aug 19;37(17):2627-9. DM52SDO RU https://pubmed.ncbi.nlm.nih.gov/8064792 DM52SDO DI DM52SDO DM52SDO DN 6-Methoxy-3-pyridin-4-yl-quinoline DM52SDO MI TTI7421 DM52SDO MN Platelet-derived growth factor receptor beta (PDGFRB) DM52SDO MT DTT DM52SDO MA Inhibitor DM52SDO RN 5,7-Dimethoxy-3-(4-pyridinyl)quinoline is a potent and selective inhibitor of human vascular beta-type platelet-derived growth factor receptor tyro... J Med Chem. 1994 Aug 19;37(17):2627-9. DM52SDO RU https://pubmed.ncbi.nlm.nih.gov/8064792 DMOYL71 DI DMOYL71 DMOYL71 DN 6-Methoxy-3-thiophen-3-yl-quinoline DMOYL71 MI TT8FYO9 DMOYL71 MN Platelet-derived growth factor receptor alpha (PDGFRA) DMOYL71 MT DTT DMOYL71 MA Inhibitor DMOYL71 RN A new series of PDGF receptor tyrosine kinase inhibitors: 3-substituted quinoline derivatives. J Med Chem. 1994 Jul 8;37(14):2129-37. DMOYL71 RU https://pubmed.ncbi.nlm.nih.gov/8035419 DMOYL71 DI DMOYL71 DMOYL71 DN 6-Methoxy-3-thiophen-3-yl-quinoline DMOYL71 MI TTI7421 DMOYL71 MN Platelet-derived growth factor receptor beta (PDGFRB) DMOYL71 MT DTT DMOYL71 MA Inhibitor DMOYL71 RN A new series of PDGF receptor tyrosine kinase inhibitors: 3-substituted quinoline derivatives. J Med Chem. 1994 Jul 8;37(14):2129-37. DMOYL71 RU https://pubmed.ncbi.nlm.nih.gov/8035419 DM98FQO DI DM98FQO DM98FQO DN 6-Methoxy-4,9-dihydro-3H-beta-carboline DM98FQO MI TT3WG5C DM98FQO MN Monoamine oxidase type A (MAO-A) DM98FQO MT DTT DM98FQO MA Inhibitor DM98FQO RN Pyrazino[1,2-a]indoles as novel high-affinity and selective imidazoline I(2) receptor ligands. Bioorg Med Chem Lett. 2004 Feb 23;14(4):1003-5. DM98FQO RU https://pubmed.ncbi.nlm.nih.gov/15013010 DM98FQO DI DM98FQO DM98FQO DN 6-Methoxy-4,9-dihydro-3H-beta-carboline DM98FQO MI TTGP7BY DM98FQO MN Monoamine oxidase type B (MAO-B) DM98FQO MT DTT DM98FQO MA Inhibitor DM98FQO RN Pyrazino[1,2-a]indoles as novel high-affinity and selective imidazoline I(2) receptor ligands. Bioorg Med Chem Lett. 2004 Feb 23;14(4):1003-5. DM98FQO RU https://pubmed.ncbi.nlm.nih.gov/15013010 DMPB9MY DI DMPB9MY DMPB9MY DN 6-Methoxy-4-morpholin-4-yl-chromen-2-one DMPB9MY MI TTK3PY9 DMPB9MY MN DNA-dependent protein kinase catalytic (PRKDC) DMPB9MY MT DTT DMPB9MY MA Inhibitor DMPB9MY RN Selective benzopyranone and pyrimido[2,1-a]isoquinolin-4-one inhibitors of DNA-dependent protein kinase: synthesis, structure-activity studies, and... J Med Chem. 2005 Jan 27;48(2):569-85. DMPB9MY RU https://pubmed.ncbi.nlm.nih.gov/15658870 DMHO7TZ DI DMHO7TZ DMHO7TZ DN 6-Methoxy-5-oxazol-5-yl-2-phenyl-1H-indole DMHO7TZ MI TTTB4UP DMHO7TZ MN Inosine-5'-monophosphate dehydrogenase 2 (IMPDH2) DMHO7TZ MT DTT DMHO7TZ MA Inhibitor DMHO7TZ RN Novel indole-based inhibitors of IMPDH: introduction of hydrogen bond acceptors at indole C-3. Bioorg Med Chem Lett. 2003 Apr 7;13(7):1273-6. DMHO7TZ RU https://pubmed.ncbi.nlm.nih.gov/12657262 DM5JB9D DI DM5JB9D DM5JB9D DN 6-methoxykaempferol 3-O-beta-D-robinobioside DM5JB9D MI TTFBNVI DM5JB9D MN Aldose reductase (AKR1B1) DM5JB9D MT DTT DM5JB9D MA Inhibitor DM5JB9D RN Flavonoids with anti-cataract activity from Brickellia arguta. J Nat Prod. 1984 Mar-Apr;47(2):316-9. DM5JB9D RU https://pubmed.ncbi.nlm.nih.gov/6429283 DMOIC64 DI DMOIC64 DMOIC64 DN 6-Methyl-[1,3]dioxolo[4,5-h]quinolin-8(9H)-one DMOIC64 MI TTJLP0R DMOIC64 MN Quinone reductase 2 (NQO2) DMOIC64 MT DTT DMOIC64 MA Inhibitor DMOIC64 RN Synthesis of casimiroin and optimization of its quinone reductase 2 and aromatase inhibitory activities. J Med Chem. 2009 Apr 9;52(7):1873-84. DMOIC64 RU https://pubmed.ncbi.nlm.nih.gov/19265439 DMAQGZR DI DMAQGZR DMAQGZR DN 6-Methyl-2-m-tolyl-1H-[1,8]naphthyridin-4-one DMAQGZR MI TTML2WA DMAQGZR MN Tubulin (TUB) DMAQGZR MT DTT DMAQGZR MA Inhibitor DMAQGZR RN Antitumor agents. 178. Synthesis and biological evaluation of substituted 2-aryl-1,8-naphthyridin-4(1H)-ones as antitumor agents that inhibit tubul... J Med Chem. 1997 Sep 12;40(19):3049-56. DMAQGZR RU https://pubmed.ncbi.nlm.nih.gov/9301667 DMAQGZR DI DMAQGZR DMAQGZR DN 6-Methyl-2-m-tolyl-1H-[1,8]naphthyridin-4-one DMAQGZR MI TTYFKSZ DMAQGZR MN Tubulin beta (TUBB) DMAQGZR MT DTT DMAQGZR MA Inhibitor DMAQGZR RN Antitumor agents. 178. Synthesis and biological evaluation of substituted 2-aryl-1,8-naphthyridin-4(1H)-ones as antitumor agents that inhibit tubul... J Med Chem. 1997 Sep 12;40(19):3049-56. DMAQGZR RU https://pubmed.ncbi.nlm.nih.gov/9301667 DMNJRFP DI DMNJRFP DMNJRFP DN 6-Methyl-2-oxa-spiro[4.4]nonan-1-one DMNJRFP MI TT1MPAY DMNJRFP MN GABA(A) receptor alpha-1 (GABRA1) DMNJRFP MT DTT DMNJRFP MA Inhibitor DMNJRFP RN Alpha-spirocyclopentyl- and alpha-spirocyclopropyl-gamma-butyrolactones: conformationally constrained derivatives of anticonvulsant and convulsant ... J Med Chem. 1994 Jan 21;37(2):275-86. DMNJRFP RU https://pubmed.ncbi.nlm.nih.gov/8295215 DMNJRFP DI DMNJRFP DMNJRFP DN 6-Methyl-2-oxa-spiro[4.4]nonan-1-one DMNJRFP MI TTZA1NY DMNJRFP MN GABA(A) receptor beta-2 (GABRB2) DMNJRFP MT DTT DMNJRFP MA Inhibitor DMNJRFP RN Alpha-spirocyclopentyl- and alpha-spirocyclopropyl-gamma-butyrolactones: conformationally constrained derivatives of anticonvulsant and convulsant ... J Med Chem. 1994 Jan 21;37(2):275-86. DMNJRFP RU https://pubmed.ncbi.nlm.nih.gov/8295215 DMNJRFP DI DMNJRFP DMNJRFP DN 6-Methyl-2-oxa-spiro[4.4]nonan-1-one DMNJRFP MI TT06RH5 DMNJRFP MN GABA(A) receptor gamma-2 (GABRG2) DMNJRFP MT DTT DMNJRFP MA Inhibitor DMNJRFP RN Alpha-spirocyclopentyl- and alpha-spirocyclopropyl-gamma-butyrolactones: conformationally constrained derivatives of anticonvulsant and convulsant ... J Med Chem. 1994 Jan 21;37(2):275-86. DMNJRFP RU https://pubmed.ncbi.nlm.nih.gov/8295215 DMNJRFP DI DMNJRFP DMNJRFP DN 6-Methyl-2-oxa-spiro[4.4]nonan-1-one DMNJRFP MI TTNJYV2 DMNJRFP MN Gamma-aminobutyric acid receptor (GAR) DMNJRFP MT DTT DMNJRFP MA Inhibitor DMNJRFP RN Alpha-spirocyclopentyl- and alpha-spirocyclopropyl-gamma-butyrolactones: conformationally constrained derivatives of anticonvulsant and convulsant ... J Med Chem. 1994 Jan 21;37(2):275-86. DMNJRFP RU https://pubmed.ncbi.nlm.nih.gov/8295215 DMZ6HQL DI DMZ6HQL DMZ6HQL DN 6-methyl-2-oxo-2H-chromene-3-carboxylic acid DMZ6HQL MI TTUNARX DMZ6HQL MN Carbonic anhydrase (CA) DMZ6HQL MT DTT DMZ6HQL MA Inhibitor DMZ6HQL RN Deciphering the mechanism of carbonic anhydrase inhibition with coumarins and thiocoumarins. J Med Chem. 2010 Jan 14;53(1):335-44. DMZ6HQL RU https://pubmed.ncbi.nlm.nih.gov/19911821 DMZ6HQL DI DMZ6HQL DMZ6HQL DN 6-methyl-2-oxo-2H-chromene-3-carboxylic acid DMZ6HQL MI TTHQPL7 DMZ6HQL MN Carbonic anhydrase I (CA-I) DMZ6HQL MT DTT DMZ6HQL MA Inhibitor DMZ6HQL RN Deciphering the mechanism of carbonic anhydrase inhibition with coumarins and thiocoumarins. J Med Chem. 2010 Jan 14;53(1):335-44. DMZ6HQL RU https://pubmed.ncbi.nlm.nih.gov/19911821 DMZ6HQL DI DMZ6HQL DMZ6HQL DN 6-methyl-2-oxo-2H-chromene-3-carboxylic acid DMZ6HQL MI TTANPDJ DMZ6HQL MN Carbonic anhydrase II (CA-II) DMZ6HQL MT DTT DMZ6HQL MA Inhibitor DMZ6HQL RN Deciphering the mechanism of carbonic anhydrase inhibition with coumarins and thiocoumarins. J Med Chem. 2010 Jan 14;53(1):335-44. DMZ6HQL RU https://pubmed.ncbi.nlm.nih.gov/19911821 DMZ6HQL DI DMZ6HQL DMZ6HQL DN 6-methyl-2-oxo-2H-chromene-3-carboxylic acid DMZ6HQL MI TTZHA0O DMZ6HQL MN Carbonic anhydrase IV (CA-IV) DMZ6HQL MT DTT DMZ6HQL MA Inhibitor DMZ6HQL RN Deciphering the mechanism of carbonic anhydrase inhibition with coumarins and thiocoumarins. J Med Chem. 2010 Jan 14;53(1):335-44. DMZ6HQL RU https://pubmed.ncbi.nlm.nih.gov/19911821 DMZ6HQL DI DMZ6HQL DMZ6HQL DN 6-methyl-2-oxo-2H-chromene-3-carboxylic acid DMZ6HQL MI TT2LVK8 DMZ6HQL MN Carbonic anhydrase IX (CA-IX) DMZ6HQL MT DTT DMZ6HQL MA Inhibitor DMZ6HQL RN Deciphering the mechanism of carbonic anhydrase inhibition with coumarins and thiocoumarins. J Med Chem. 2010 Jan 14;53(1):335-44. DMZ6HQL RU https://pubmed.ncbi.nlm.nih.gov/19911821 DMZ6HQL DI DMZ6HQL DMZ6HQL DN 6-methyl-2-oxo-2H-chromene-3-carboxylic acid DMZ6HQL MI TTSYM0R DMZ6HQL MN Carbonic anhydrase XII (CA-XII) DMZ6HQL MT DTT DMZ6HQL MA Inhibitor DMZ6HQL RN Deciphering the mechanism of carbonic anhydrase inhibition with coumarins and thiocoumarins. J Med Chem. 2010 Jan 14;53(1):335-44. DMZ6HQL RU https://pubmed.ncbi.nlm.nih.gov/19911821 DMZ6HQL DI DMZ6HQL DMZ6HQL DN 6-methyl-2-oxo-2H-chromene-3-carboxylic acid DMZ6HQL MI TTEYTKG DMZ6HQL MN Carbonic anhydrase XIV (CA-XIV) DMZ6HQL MT DTT DMZ6HQL MA Inhibitor DMZ6HQL RN Deciphering the mechanism of carbonic anhydrase inhibition with coumarins and thiocoumarins. J Med Chem. 2010 Jan 14;53(1):335-44. DMZ6HQL RU https://pubmed.ncbi.nlm.nih.gov/19911821 DMAXBOU DI DMAXBOU DMAXBOU DN 6-Methyl-2-phenyl-chromen-4-one DMAXBOU MI TTNJYV2 DMAXBOU MN Gamma-aminobutyric acid receptor (GAR) DMAXBOU MT DTT DMAXBOU MA Inhibitor DMAXBOU RN Refinement and evaluation of a pharmacophore model for flavone derivatives binding to the benzodiazepine site of the GABA(A) receptor. J Med Chem. 2002 Sep 12;45(19):4188-201. DMAXBOU RU https://pubmed.ncbi.nlm.nih.gov/12213060 DM8KMEG DI DM8KMEG DM8KMEG DN 6-Methyl-2-p-tolyl-chromen-4-one DM8KMEG MI TTNJYV2 DM8KMEG MN Gamma-aminobutyric acid receptor (GAR) DM8KMEG MT DTT DM8KMEG MA Inhibitor DM8KMEG RN Refinement and evaluation of a pharmacophore model for flavone derivatives binding to the benzodiazepine site of the GABA(A) receptor. J Med Chem. 2002 Sep 12;45(19):4188-201. DM8KMEG RU https://pubmed.ncbi.nlm.nih.gov/12213060 DMFMK6Y DI DMFMK6Y DMFMK6Y DN 6-Methyl-2-pyridin-3-yl-chromen-4-one DMFMK6Y MI TTNJYV2 DMFMK6Y MN Gamma-aminobutyric acid receptor (GAR) DMFMK6Y MT DTT DMFMK6Y MA Inhibitor DMFMK6Y RN Refinement and evaluation of a pharmacophore model for flavone derivatives binding to the benzodiazepine site of the GABA(A) receptor. J Med Chem. 2002 Sep 12;45(19):4188-201. DMFMK6Y RU https://pubmed.ncbi.nlm.nih.gov/12213060 DMOVUP2 DI DMOVUP2 DMOVUP2 DN 6-Methyl-4-(4-benzoylpiperazin-1-yl)coumarin DMOVUP2 MI TT1RS9F DMOVUP2 MN Acetylcholinesterase (AChE) DMOVUP2 MT DTT DMOVUP2 MA Inhibitor DMOVUP2 RN Design, synthesis, and acetylcholinesterase inhibitory activity of novel coumarin analogues. Bioorg Med Chem. 2008 Sep 1;16(17):8011-21. DMOVUP2 RU https://pubmed.ncbi.nlm.nih.gov/18701305 DMN0SYW DI DMN0SYW DMN0SYW DN 6-Methyl-4-(4-o-tolylpiperazin-1-yl)coumarin DMN0SYW MI TT1RS9F DMN0SYW MN Acetylcholinesterase (AChE) DMN0SYW MT DTT DMN0SYW MA Inhibitor DMN0SYW RN Design, synthesis, and acetylcholinesterase inhibitory activity of novel coumarin analogues. Bioorg Med Chem. 2008 Sep 1;16(17):8011-21. DMN0SYW RU https://pubmed.ncbi.nlm.nih.gov/18701305 DMU7E3O DI DMU7E3O DMU7E3O DN 6-Methyl-4-(4-phenylpiperazin-1-yl)coumarin DMU7E3O MI TT1RS9F DMU7E3O MN Acetylcholinesterase (AChE) DMU7E3O MT DTT DMU7E3O MA Inhibitor DMU7E3O RN Design, synthesis, and acetylcholinesterase inhibitory activity of novel coumarin analogues. Bioorg Med Chem. 2008 Sep 1;16(17):8011-21. DMU7E3O RU https://pubmed.ncbi.nlm.nih.gov/18701305 DM1LW62 DI DM1LW62 DM1LW62 DN 6-methyl-4-(piperazin-1-yl)furo[2,3-d]pyrimidine DM1LW62 MI TTWJBZ5 DM1LW62 MN 5-HT 2C receptor (HTR2C) DM1LW62 MT DTT DM1LW62 MA Inhibitor DM1LW62 RN Design and synthesis of orally-active and selective azaindane 5HT2c agonist for the treatment of obesity. Bioorg Med Chem Lett. 2010 Jan 1;20(1):266-71. DM1LW62 RU https://pubmed.ncbi.nlm.nih.gov/19914063 DMO7RPW DI DMO7RPW DMO7RPW DN 6-Methyl-4-morpholin-4-yl-chromen-2-one DMO7RPW MI TTK3PY9 DMO7RPW MN DNA-dependent protein kinase catalytic (PRKDC) DMO7RPW MT DTT DMO7RPW MA Inhibitor DMO7RPW RN Selective benzopyranone and pyrimido[2,1-a]isoquinolin-4-one inhibitors of DNA-dependent protein kinase: synthesis, structure-activity studies, and... J Med Chem. 2005 Jan 27;48(2):569-85. DMO7RPW RU https://pubmed.ncbi.nlm.nih.gov/15658870 DMSLT3I DI DMSLT3I DMSLT3I DN 6-methyl-5,6-dihydro-4H-1,3-thiazin-2-amine DMSLT3I MI TTF10I9 DMSLT3I MN Nitric-oxide synthase inducible (NOS2) DMSLT3I MT DTT DMSLT3I MA Inhibitor DMSLT3I RN Synthesis of biflavones having a 6-O-7'' linkage and effects on cyclooxygenase-2 and inducible nitric oxide synthase. Bioorg Med Chem Lett. 2009 Jan 1;19(1):74-6. DMSLT3I RU https://pubmed.ncbi.nlm.nih.gov/19041241 DMN6IDK DI DMN6IDK DMN6IDK DN 6-Methylamino-5-Nitroisocytosine DMN6IDK MI TT4ILYC DMN6IDK MN Bacterial Dihydropteroate synthetase (Bact folP) DMN6IDK MT DTT DMN6IDK MA Inhibitor DMN6IDK RN DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Nucleic Acids Res. 2011 Jan;39(Database issue):D1035-41. DMN6IDK RU https://pubmed.ncbi.nlm.nih.gov/21059682 DMTG8D0 DI DMTG8D0 DMTG8D0 DN 6'-methylepibatidine DMTG8D0 MI TT4H1MQ DMTG8D0 MN Neuronal acetylcholine receptor alpha-4 (CHRNA4) DMTG8D0 MT DTT DMTG8D0 MA Inhibitor DMTG8D0 RN Synthesis and nicotinic acetylcholine receptor binding properties of bridged and fused ring analogues of epibatidine. J Med Chem. 2007 Dec 13;50(25):6383-91. DMTG8D0 RU https://pubmed.ncbi.nlm.nih.gov/17994682 DMTG8D0 DI DMTG8D0 DMTG8D0 DN 6'-methylepibatidine DMTG8D0 MI TT5KPZR DMTG8D0 MN Neuronal acetylcholine receptor beta-2 (CHRNB2) DMTG8D0 MT DTT DMTG8D0 MA Inhibitor DMTG8D0 RN Synthesis and nicotinic acetylcholine receptor binding properties of bridged and fused ring analogues of epibatidine. J Med Chem. 2007 Dec 13;50(25):6383-91. DMTG8D0 RU https://pubmed.ncbi.nlm.nih.gov/17994682 DMTNZKU DI DMTNZKU DMTNZKU DN 6-MORPHOLIN-4-YL-9H-PURINE DMTNZKU MI TTTU902 DMTNZKU MN Checkpoint kinase-1 (CHK1) DMTNZKU MT DTT DMTNZKU MA Inhibitor DMTNZKU RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DMTNZKU RU https://pubmed.ncbi.nlm.nih.gov/10592235 DMHU78R DI DMHU78R DMHU78R DN 6-m-Tolyl-pteridine-2,4,7-triamine DMHU78R MI TT9SL3Q DMHU78R MN Polypeptide deformylase (PDF) DMHU78R MT DTT DMHU78R MA Inhibitor DMHU78R RN Further studies on 2,4-diamino-5-(2',5'-disubstituted benzyl)pyrimidines as potent and selective inhibitors of dihydrofolate reductases from three ... J Med Chem. 2003 Apr 24;46(9):1726-36. DMHU78R RU https://pubmed.ncbi.nlm.nih.gov/12699390 DM84CTA DI DM84CTA DM84CTA DN 6-Nitro-1,4-dihydro-quinoxaline-2,3-dione DM84CTA MI TTLD29N DM84CTA MN Glutamate receptor ionotropic NMDA 1 (NMDAR1) DM84CTA MT DTT DM84CTA MA Inhibitor DM84CTA RN 5-(N-oxyaza)-7-substituted-1,4-dihydroquinoxaline-2,3-diones: novel, systemically active and broad spectrum antagonists for NMDA/glycine, AMPA, and... J Med Chem. 1997 Oct 24;40(22):3679-86. DM84CTA RU https://pubmed.ncbi.nlm.nih.gov/9357535 DM84CTA DI DM84CTA DM84CTA DN 6-Nitro-1,4-dihydro-quinoxaline-2,3-dione DM84CTA MI TTKJEMQ DM84CTA MN Glutamate receptor ionotropic NMDA 2A (NMDAR2A) DM84CTA MT DTT DM84CTA MA Inhibitor DM84CTA RN 5-(N-oxyaza)-7-substituted-1,4-dihydroquinoxaline-2,3-diones: novel, systemically active and broad spectrum antagonists for NMDA/glycine, AMPA, and... J Med Chem. 1997 Oct 24;40(22):3679-86. DM84CTA RU https://pubmed.ncbi.nlm.nih.gov/9357535 DM84CTA DI DM84CTA DM84CTA DN 6-Nitro-1,4-dihydro-quinoxaline-2,3-dione DM84CTA MI TTN9D8E DM84CTA MN Glutamate receptor ionotropic NMDA 2B (NMDAR2B) DM84CTA MT DTT DM84CTA MA Inhibitor DM84CTA RN 5-(N-oxyaza)-7-substituted-1,4-dihydroquinoxaline-2,3-diones: novel, systemically active and broad spectrum antagonists for NMDA/glycine, AMPA, and... J Med Chem. 1997 Oct 24;40(22):3679-86. DM84CTA RU https://pubmed.ncbi.nlm.nih.gov/9357535 DMRCTBA DI DMRCTBA DMRCTBA DN 6-Nitro-2-(3-nitro-phenyl)-chromen-4-one DMRCTBA MI TT1MPAY DMRCTBA MN GABA(A) receptor alpha-1 (GABRA1) DMRCTBA MT DTT DMRCTBA MA Inhibitor DMRCTBA RN 6,3'-Dinitroflavone, a novel high affinity ligand for the benzodiazepine receptor with potent anxiolytic properties, Bioorg. Med. Chem. Lett. 5(22):2717-2720 (1995). DMRCTBA RU http://www.sciencedirect.com/science/article/pii/0960894X95004645 DMRCTBA DI DMRCTBA DMRCTBA DN 6-Nitro-2-(3-nitro-phenyl)-chromen-4-one DMRCTBA MI TT06RH5 DMRCTBA MN GABA(A) receptor gamma-2 (GABRG2) DMRCTBA MT DTT DMRCTBA MA Inhibitor DMRCTBA RN 6,3'-Dinitroflavone, a novel high affinity ligand for the benzodiazepine receptor with potent anxiolytic properties, Bioorg. Med. Chem. Lett. 5(22):2717-2720 (1995). DMRCTBA RU http://www.sciencedirect.com/science/article/pii/0960894X95004645 DMRCTBA DI DMRCTBA DMRCTBA DN 6-Nitro-2-(3-nitro-phenyl)-chromen-4-one DMRCTBA MI TTNJYV2 DMRCTBA MN Gamma-aminobutyric acid receptor (GAR) DMRCTBA MT DTT DMRCTBA MA Inhibitor DMRCTBA RN 6,3'-Dinitroflavone, a novel high affinity ligand for the benzodiazepine receptor with potent anxiolytic properties, Bioorg. Med. Chem. Lett. 5(22):2717-2720 (1995). DMRCTBA RU http://www.sciencedirect.com/science/article/pii/0960894X95004645 DMM635K DI DMM635K DMM635K DN 6-Nitro-2-(4-nitro-phenyl)-chromen-4-one DMM635K MI TT1MPAY DMM635K MN GABA(A) receptor alpha-1 (GABRA1) DMM635K MT DTT DMM635K MA Inhibitor DMM635K RN 6,3'-Dinitroflavone, a novel high affinity ligand for the benzodiazepine receptor with potent anxiolytic properties, Bioorg. Med. Chem. Lett. 5(22):2717-2720 (1995). DMM635K RU http://www.sciencedirect.com/science/article/pii/0960894X95004645 DMM635K DI DMM635K DMM635K DN 6-Nitro-2-(4-nitro-phenyl)-chromen-4-one DMM635K MI TT06RH5 DMM635K MN GABA(A) receptor gamma-2 (GABRG2) DMM635K MT DTT DMM635K MA Inhibitor DMM635K RN 6,3'-Dinitroflavone, a novel high affinity ligand for the benzodiazepine receptor with potent anxiolytic properties, Bioorg. Med. Chem. Lett. 5(22):2717-2720 (1995). DMM635K RU http://www.sciencedirect.com/science/article/pii/0960894X95004645 DMM635K DI DMM635K DMM635K DN 6-Nitro-2-(4-nitro-phenyl)-chromen-4-one DMM635K MI TTNJYV2 DMM635K MN Gamma-aminobutyric acid receptor (GAR) DMM635K MT DTT DMM635K MA Inhibitor DMM635K RN 6,3'-Dinitroflavone, a novel high affinity ligand for the benzodiazepine receptor with potent anxiolytic properties, Bioorg. Med. Chem. Lett. 5(22):2717-2720 (1995). DMM635K RU http://www.sciencedirect.com/science/article/pii/0960894X95004645 DMZTXDV DI DMZTXDV DMZTXDV DN 6-Nitro-2-(4-phenoxy-benzyl)-1H-benzoimidazole DMZTXDV MI TTLD29N DMZTXDV MN Glutamate receptor ionotropic NMDA 1 (NMDAR1) DMZTXDV MT DTT DMZTXDV MA Inhibitor DMZTXDV RN NR2B-selective N-methyl-D-aspartate antagonists: synthesis and evaluation of 5-substituted benzimidazoles. J Med Chem. 2004 Apr 8;47(8):2089-96. DMZTXDV RU https://pubmed.ncbi.nlm.nih.gov/15056006 DMZTXDV DI DMZTXDV DMZTXDV DN 6-Nitro-2-(4-phenoxy-benzyl)-1H-benzoimidazole DMZTXDV MI TTN9D8E DMZTXDV MN Glutamate receptor ionotropic NMDA 2B (NMDAR2B) DMZTXDV MT DTT DMZTXDV MA Inhibitor DMZTXDV RN NR2B-selective N-methyl-D-aspartate antagonists: synthesis and evaluation of 5-substituted benzimidazoles. J Med Chem. 2004 Apr 8;47(8):2089-96. DMZTXDV RU https://pubmed.ncbi.nlm.nih.gov/15056006 DMVLID9 DI DMVLID9 DMVLID9 DN 6-Nitro-2-phenyl-chromen-4-one DMVLID9 MI TT1MPAY DMVLID9 MN GABA(A) receptor alpha-1 (GABRA1) DMVLID9 MT DTT DMVLID9 MA Inhibitor DMVLID9 RN Synthesis of halogenated/nitrated flavone derivatives and evaluation of their affinity for the central benzodiazepine receptor, Bioorg. Med. Chem. Lett. 7(15):2003-2008 (1997). DMVLID9 RU http://www.sciencedirect.com/science/article/pii/S0960894X97003430 DMVLID9 DI DMVLID9 DMVLID9 DN 6-Nitro-2-phenyl-chromen-4-one DMVLID9 MI TTNJYV2 DMVLID9 MN Gamma-aminobutyric acid receptor (GAR) DMVLID9 MT DTT DMVLID9 MA Inhibitor DMVLID9 RN Synthesis of halogenated/nitrated flavone derivatives and evaluation of their affinity for the central benzodiazepine receptor, Bioorg. Med. Chem. Lett. 7(15):2003-2008 (1997). DMVLID9 RU http://www.sciencedirect.com/science/article/pii/S0960894X97003430 DMAOUQI DI DMAOUQI DMAOUQI DN 6-Nitro-2-piperazin-1-yl-4-vinyl-quinoline DMAOUQI MI TT3ROYC DMAOUQI MN Serotonin transporter (SERT) DMAOUQI MT DTT DMAOUQI MA Inhibitor DMAOUQI RN Syntheses and binding affinities of 6-nitroquipazine analogues for serotonin transporter. Part 2: 4-substituted 6-nitroquipazines. Bioorg Med Chem Lett. 2002 Mar 11;12(5):811-5. DMAOUQI RU https://pubmed.ncbi.nlm.nih.gov/11859009 DMCEG6V DI DMCEG6V DMCEG6V DN 6-Nitro-4-phenyl-2-piperazin-1-yl-quinoline DMCEG6V MI TT3ROYC DMCEG6V MN Serotonin transporter (SERT) DMCEG6V MT DTT DMCEG6V MA Inhibitor DMCEG6V RN Syntheses and binding affinities of 6-nitroquipazine analogues for serotonin transporter. Part 2: 4-substituted 6-nitroquipazines. Bioorg Med Chem Lett. 2002 Mar 11;12(5):811-5. DMCEG6V RU https://pubmed.ncbi.nlm.nih.gov/11859009 DMYP7UG DI DMYP7UG DMYP7UG DN 6-Nitro-benzothiazole-2-sulfonic acid amide DMYP7UG MI TTANPDJ DMYP7UG MN Carbonic anhydrase II (CA-II) DMYP7UG MT DTT DMYP7UG MA Inhibitor DMYP7UG RN Carbonic anhydrase inhibitors: inhibition of human cytosolic isozyme II and mitochondrial isozyme V with a series of benzene sulfonamide derivatives. Bioorg Med Chem Lett. 2004 Nov 15;14(22):5703-7. DMYP7UG RU https://pubmed.ncbi.nlm.nih.gov/15482952 DM2WZCX DI DM2WZCX DM2WZCX DN 6-Nitroindazole DM2WZCX MI TTCM4B3 DM2WZCX MN Nitric-oxide synthase endothelial (NOS3) DM2WZCX MT DTT DM2WZCX MA Inhibitor DM2WZCX RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DM2WZCX RU https://pubmed.ncbi.nlm.nih.gov/17139284 DM2WZCX DI DM2WZCX DM2WZCX DN 6-Nitroindazole DM2WZCX MI TTF10I9 DM2WZCX MN Nitric-oxide synthase inducible (NOS2) DM2WZCX MT DTT DM2WZCX MA Inhibitor DM2WZCX RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DM2WZCX RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMXJFCQ DI DMXJFCQ DMXJFCQ DN 6-n-octylaminouracil DMXJFCQ MI TTG0MQD DMXJFCQ MN Inflammation-related GPCR EX33 (GPR84) DMXJFCQ MT DTT DMXJFCQ MA Agonist DMXJFCQ RN Medium-chain fatty acid-sensing receptor, GPR84, is a proinflammatory receptor. J Biol Chem. 2013 Apr 12;288(15):10684-91. DMXJFCQ RU https://pubmed.ncbi.nlm.nih.gov/23449982 DMDPA2T DI DMDPA2T DMDPA2T DN 6-N-propyl -4-trifluoromethylquinolin-2(1H)-one DMDPA2T MI TTKPW01 DMDPA2T MN Androgen receptor messenger RNA (AR mRNA) DMDPA2T MT DTT DMDPA2T MA Inhibitor DMDPA2T RN Discovery of 6-N,N-bis(2,2,2-trifluoroethyl)amino- 4-trifluoromethylquinolin-2(1H)-one as a novel selective androgen receptor modulator. J Med Chem. 2006 Oct 19;49(21):6143-6. DMDPA2T RU https://pubmed.ncbi.nlm.nih.gov/17034117 DMDIW08 DI DMDIW08 DMDIW08 DN 6-O-Cyclohexylmethyl Guanine DMDIW08 MI TTAMQ62 DMDIW08 MN Cyclin A2 (CCNA2) DMDIW08 MT DTT DMDIW08 MA Inhibitor DMDIW08 RN N2-substituted O6-cyclohexylmethylguanine derivatives: potent inhibitors of cyclin-dependent kinases 1 and 2. J Med Chem. 2004 Jul 15;47(15):3710-22. DMDIW08 RU https://pubmed.ncbi.nlm.nih.gov/15239650 DMDIW08 DI DMDIW08 DMDIW08 DN 6-O-Cyclohexylmethyl Guanine DMDIW08 MI TT7HF4W DMDIW08 MN Cyclin-dependent kinase 2 (CDK2) DMDIW08 MT DTT DMDIW08 MA Inhibitor DMDIW08 RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMDIW08 RU https://pubmed.ncbi.nlm.nih.gov/17139284 DM6YHBR DI DM6YHBR DM6YHBR DN 6-O-Phosphoryl Inosine Monophosphate DM6YHBR MI TTYQ4AE DM6YHBR MN Plasmodium Adenylosuccinate synthetase (Malaria Adss) DM6YHBR MT DTT DM6YHBR MA Inhibitor DM6YHBR RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DM6YHBR RU https://pubmed.ncbi.nlm.nih.gov/17139284 DM4TX9O DI DM4TX9O DM4TX9O DN 6-o-tolylquinazolin-2-amine DM4TX9O MI TTT7PJU DM4TX9O MN Janus kinase 3 (JAK-3) DM4TX9O MT DTT DM4TX9O MA Inhibitor DM4TX9O RN Discovery of aminoquinazolines as potent, orally bioavailable inhibitors of Lck: synthesis, SAR, and in vivo anti-inflammatory activity. J Med Chem. 2006 Sep 21;49(19):5671-86. DM4TX9O RU https://pubmed.ncbi.nlm.nih.gov/16970394 DM4TX9O DI DM4TX9O DM4TX9O DN 6-o-tolylquinazolin-2-amine DM4TX9O MI TT860QF DM4TX9O MN LCK tyrosine protein kinase (LCK) DM4TX9O MT DTT DM4TX9O MA Inhibitor DM4TX9O RN Discovery of aminoquinazolines as potent, orally bioavailable inhibitors of Lck: synthesis, SAR, and in vivo anti-inflammatory activity. J Med Chem. 2006 Sep 21;49(19):5671-86. DM4TX9O RU https://pubmed.ncbi.nlm.nih.gov/16970394 DM4TX9O DI DM4TX9O DM4TX9O DN 6-o-tolylquinazolin-2-amine DM4TX9O MI TTQBR95 DM4TX9O MN Stress-activated protein kinase 2a (p38 alpha) DM4TX9O MT DTT DM4TX9O MA Inhibitor DM4TX9O RN Discovery of aminoquinazolines as potent, orally bioavailable inhibitors of Lck: synthesis, SAR, and in vivo anti-inflammatory activity. J Med Chem. 2006 Sep 21;49(19):5671-86. DM4TX9O RU https://pubmed.ncbi.nlm.nih.gov/16970394 DM4TX9O DI DM4TX9O DM4TX9O DN 6-o-tolylquinazolin-2-amine DM4TX9O MI TTUTJGQ DM4TX9O MN Vascular endothelial growth factor receptor 2 (KDR) DM4TX9O MT DTT DM4TX9O MA Inhibitor DM4TX9O RN Discovery of aminoquinazolines as potent, orally bioavailable inhibitors of Lck: synthesis, SAR, and in vivo anti-inflammatory activity. J Med Chem. 2006 Sep 21;49(19):5671-86. DM4TX9O RU https://pubmed.ncbi.nlm.nih.gov/16970394 DMPBE5H DI DMPBE5H DMPBE5H DN 6-oxo-16-formyl-estrone DMPBE5H MI TTIWB6L DMPBE5H MN Estradiol 17 beta-dehydrogenase 1 (17-beta-HSD1) DMPBE5H MT DTT DMPBE5H MA Inhibitor DMPBE5H RN Modification of estrone at the 6, 16, and 17 positions: novel potent inhibitors of 17beta-hydroxysteroid dehydrogenase type 1. J Med Chem. 2006 Feb 23;49(4):1325-45. DMPBE5H RU https://pubmed.ncbi.nlm.nih.gov/16480268 DMKMYAJ DI DMKMYAJ DMKMYAJ DN 6-oxo-estrone DMKMYAJ MI TTIWB6L DMKMYAJ MN Estradiol 17 beta-dehydrogenase 1 (17-beta-HSD1) DMKMYAJ MT DTT DMKMYAJ MA Inhibitor DMKMYAJ RN Modification of estrone at the 6, 16, and 17 positions: novel potent inhibitors of 17beta-hydroxysteroid dehydrogenase type 1. J Med Chem. 2006 Feb 23;49(4):1325-45. DMKMYAJ RU https://pubmed.ncbi.nlm.nih.gov/16480268 DMVYIN2 DI DMVYIN2 DMVYIN2 DN 6-Phenoxy-hexane-1-thiol DMVYIN2 MI TTBH0VX DMVYIN2 MN Histone deacetylase (HDAC) DMVYIN2 MT DTT DMVYIN2 MA Inhibitor DMVYIN2 RN Novel inhibitors of human histone deacetylases: design, synthesis, enzyme inhibition, and cancer cell growth inhibition of SAHA-based non-hydroxama... J Med Chem. 2005 Feb 24;48(4):1019-32. DMVYIN2 RU https://pubmed.ncbi.nlm.nih.gov/15715470 DMVYIN2 DI DMVYIN2 DMVYIN2 DN 6-Phenoxy-hexane-1-thiol DMVYIN2 MI TT6R7JZ DMVYIN2 MN Histone deacetylase 1 (HDAC1) DMVYIN2 MT DTT DMVYIN2 MA Inhibitor DMVYIN2 RN Novel inhibitors of human histone deacetylases: design, synthesis, enzyme inhibition, and cancer cell growth inhibition of SAHA-based non-hydroxama... J Med Chem. 2005 Feb 24;48(4):1019-32. DMVYIN2 RU https://pubmed.ncbi.nlm.nih.gov/15715470 DMVYIN2 DI DMVYIN2 DMVYIN2 DN 6-Phenoxy-hexane-1-thiol DMVYIN2 MI TTYHPU6 DMVYIN2 MN Histone deacetylase 10 (HDAC10) DMVYIN2 MT DTT DMVYIN2 MA Inhibitor DMVYIN2 RN Novel inhibitors of human histone deacetylases: design, synthesis, enzyme inhibition, and cancer cell growth inhibition of SAHA-based non-hydroxama... J Med Chem. 2005 Feb 24;48(4):1019-32. DMVYIN2 RU https://pubmed.ncbi.nlm.nih.gov/15715470 DMVYIN2 DI DMVYIN2 DMVYIN2 DN 6-Phenoxy-hexane-1-thiol DMVYIN2 MI TTSHTOI DMVYIN2 MN Histone deacetylase 2 (HDAC2) DMVYIN2 MT DTT DMVYIN2 MA Inhibitor DMVYIN2 RN Novel inhibitors of human histone deacetylases: design, synthesis, enzyme inhibition, and cancer cell growth inhibition of SAHA-based non-hydroxama... J Med Chem. 2005 Feb 24;48(4):1019-32. DMVYIN2 RU https://pubmed.ncbi.nlm.nih.gov/15715470 DMVYIN2 DI DMVYIN2 DMVYIN2 DN 6-Phenoxy-hexane-1-thiol DMVYIN2 MI TTTQGH8 DMVYIN2 MN Histone deacetylase 4 (HDAC4) DMVYIN2 MT DTT DMVYIN2 MA Inhibitor DMVYIN2 RN Novel inhibitors of human histone deacetylases: design, synthesis, enzyme inhibition, and cancer cell growth inhibition of SAHA-based non-hydroxama... J Med Chem. 2005 Feb 24;48(4):1019-32. DMVYIN2 RU https://pubmed.ncbi.nlm.nih.gov/15715470 DMVYIN2 DI DMVYIN2 DMVYIN2 DN 6-Phenoxy-hexane-1-thiol DMVYIN2 MI TT5ZKDI DMVYIN2 MN Histone deacetylase 6 (HDAC6) DMVYIN2 MT DTT DMVYIN2 MA Inhibitor DMVYIN2 RN Novel inhibitors of human histone deacetylases: design, synthesis, enzyme inhibition, and cancer cell growth inhibition of SAHA-based non-hydroxama... J Med Chem. 2005 Feb 24;48(4):1019-32. DMVYIN2 RU https://pubmed.ncbi.nlm.nih.gov/15715470 DMVYIN2 DI DMVYIN2 DMVYIN2 DN 6-Phenoxy-hexane-1-thiol DMVYIN2 MI TTT6LFV DMVYIN2 MN Histone deacetylase 8 (HDAC8) DMVYIN2 MT DTT DMVYIN2 MA Inhibitor DMVYIN2 RN Novel inhibitors of human histone deacetylases: design, synthesis, enzyme inhibition, and cancer cell growth inhibition of SAHA-based non-hydroxama... J Med Chem. 2005 Feb 24;48(4):1019-32. DMVYIN2 RU https://pubmed.ncbi.nlm.nih.gov/15715470 DM3UBR5 DI DM3UBR5 DM3UBR5 DN 6-phenyl-3-(pyridin-4-yl)-1H-indole DM3UBR5 MI TTTB4UP DM3UBR5 MN Inosine-5'-monophosphate dehydrogenase 2 (IMPDH2) DM3UBR5 MT DTT DM3UBR5 MA Inhibitor DM3UBR5 RN Novel indole inhibitors of IMPDH from fragments: synthesis and initial structure-activity relationships. Bioorg Med Chem Lett. 2006 May 1;16(9):2539-42. DM3UBR5 RU https://pubmed.ncbi.nlm.nih.gov/16483773 DMG6PZT DI DMG6PZT DMG6PZT DN 6-Phenylaminomethyl-quinazoline-2,4-diamine DMG6PZT MI TT9SL3Q DMG6PZT MN Polypeptide deformylase (PDF) DMG6PZT MT DTT DMG6PZT MA Inhibitor DMG6PZT RN Design and synthesis of dihydrofolate reductase inhibitors encompassing a bridging ester group. Evaluation in a mouse colitis model. J Med Chem. 2003 Jul 31;46(16):3455-62. DMG6PZT RU https://pubmed.ncbi.nlm.nih.gov/12877583 DMIKRP6 DI DMIKRP6 DMIKRP6 DN 6-phenylethynyl-nicotinic acid methyl ester DMIKRP6 MI TTHS256 DMIKRP6 MN Metabotropic glutamate receptor 5 (mGluR5) DMIKRP6 MT DTT DMIKRP6 MA Inhibitor DMIKRP6 RN Positive and negative modulation of group I metabotropic glutamate receptors. J Med Chem. 2008 Feb 14;51(3):634-47. DMIKRP6 RU https://pubmed.ncbi.nlm.nih.gov/18173231 DMLJN8Z DI DMLJN8Z DMLJN8Z DN 6-Phenylhexylcarbamic Acid Biphenyl-3-yl Ester DMLJN8Z MI TTDP1UC DMLJN8Z MN Fatty acid amide hydrolase (FAAH) DMLJN8Z MT DTT DMLJN8Z MA Inhibitor DMLJN8Z RN Synthesis and quantitative structure-activity relationship of fatty acid amide hydrolase inhibitors: modulation at the N-portion of biphenyl-3-yl a... J Med Chem. 2008 Jun 26;51(12):3487-98. DMLJN8Z RU https://pubmed.ncbi.nlm.nih.gov/18507372 DMPA534 DI DMPA534 DMPA534 DN 6-Phenylmethanesulfonyl-2H-pyridazin-3-one DMPA534 MI TTFBNVI DMPA534 MN Aldose reductase (AKR1B1) DMPA534 MT DTT DMPA534 MA Inhibitor DMPA534 RN A novel series of non-carboxylic acid, non-hydantoin inhibitors of aldose reductase with potent oral activity in diabetic rat models: 6-(5-chloro-3... J Med Chem. 2005 Oct 6;48(20):6326-39. DMPA534 RU https://pubmed.ncbi.nlm.nih.gov/16190759 DMEYOF7 DI DMEYOF7 DMEYOF7 DN 6-Phenyl-naphthalen-2-ol DMEYOF7 MI TTZAYWL DMEYOF7 MN Estrogen receptor (ESR) DMEYOF7 MT DTT DMEYOF7 MA Inhibitor DMEYOF7 RN ERbeta ligands. 3. Exploiting two binding orientations of the 2-phenylnaphthalene scaffold to achieve ERbeta selectivity. J Med Chem. 2005 Jun 16;48(12):3953-79. DMEYOF7 RU https://pubmed.ncbi.nlm.nih.gov/15943471 DMEYOF7 DI DMEYOF7 DMEYOF7 DN 6-Phenyl-naphthalen-2-ol DMEYOF7 MI TTOM3J0 DMEYOF7 MN Estrogen receptor beta (ESR2) DMEYOF7 MT DTT DMEYOF7 MA Inhibitor DMEYOF7 RN ERbeta ligands. 3. Exploiting two binding orientations of the 2-phenylnaphthalene scaffold to achieve ERbeta selectivity. J Med Chem. 2005 Jun 16;48(12):3953-79. DMEYOF7 RU https://pubmed.ncbi.nlm.nih.gov/15943471 DMXTV1B DI DMXTV1B DMXTV1B DN 6-phenylpyridazin-3-yl thiophene-2-carboxylate DMXTV1B MI TT6804T DMXTV1B MN MIF messenger RNA (MIF mRNA) DMXTV1B MT DTT DMXTV1B MA Inhibitor DMXTV1B RN An integrative in silico methodology for the identification of modulators of macrophage migration inhibitory factor (MIF) tautomerase activity. Bioorg Med Chem. 2010 Jul 15;18(14):5425-40. DMXTV1B RU https://pubmed.ncbi.nlm.nih.gov/20639113 DMZ76NQ DI DMZ76NQ DMZ76NQ DN 6-Phenylsulfanyl-9H-purine DMZ76NQ MI TTQBR95 DMZ76NQ MN Stress-activated protein kinase 2a (p38 alpha) DMZ76NQ MT DTT DMZ76NQ MA Inhibitor DMZ76NQ RN Synthesis and biological testing of purine derivatives as potential ATP-competitive kinase inhibitors. J Med Chem. 2005 Feb 10;48(3):710-22. DMZ76NQ RU https://pubmed.ncbi.nlm.nih.gov/15689155 DM3OLM6 DI DM3OLM6 DM3OLM6 DN 6-phenylsulfanylhexanoic acid hydroxamide DM3OLM6 MI TTBH0VX DM3OLM6 MN Histone deacetylase (HDAC) DM3OLM6 MT DTT DM3OLM6 MA Inhibitor DM3OLM6 RN Aromatic sulfide inhibitors of histone deacetylase based on arylsulfinyl-2,4-hexadienoic acid hydroxyamides. J Med Chem. 2006 Jan 26;49(2):800-5. DM3OLM6 RU https://pubmed.ncbi.nlm.nih.gov/16420064 DM3OLM6 DI DM3OLM6 DM3OLM6 DN 6-phenylsulfanylhexanoic acid hydroxamide DM3OLM6 MI TT6R7JZ DM3OLM6 MN Histone deacetylase 1 (HDAC1) DM3OLM6 MT DTT DM3OLM6 MA Inhibitor DM3OLM6 RN Aromatic sulfide inhibitors of histone deacetylase based on arylsulfinyl-2,4-hexadienoic acid hydroxyamides. J Med Chem. 2006 Jan 26;49(2):800-5. DM3OLM6 RU https://pubmed.ncbi.nlm.nih.gov/16420064 DM3OLM6 DI DM3OLM6 DM3OLM6 DN 6-phenylsulfanylhexanoic acid hydroxamide DM3OLM6 MI TTYHPU6 DM3OLM6 MN Histone deacetylase 10 (HDAC10) DM3OLM6 MT DTT DM3OLM6 MA Inhibitor DM3OLM6 RN Aromatic sulfide inhibitors of histone deacetylase based on arylsulfinyl-2,4-hexadienoic acid hydroxyamides. J Med Chem. 2006 Jan 26;49(2):800-5. DM3OLM6 RU https://pubmed.ncbi.nlm.nih.gov/16420064 DM3OLM6 DI DM3OLM6 DM3OLM6 DN 6-phenylsulfanylhexanoic acid hydroxamide DM3OLM6 MI TTSHTOI DM3OLM6 MN Histone deacetylase 2 (HDAC2) DM3OLM6 MT DTT DM3OLM6 MA Inhibitor DM3OLM6 RN Aromatic sulfide inhibitors of histone deacetylase based on arylsulfinyl-2,4-hexadienoic acid hydroxyamides. J Med Chem. 2006 Jan 26;49(2):800-5. DM3OLM6 RU https://pubmed.ncbi.nlm.nih.gov/16420064 DM3OLM6 DI DM3OLM6 DM3OLM6 DN 6-phenylsulfanylhexanoic acid hydroxamide DM3OLM6 MI TTTQGH8 DM3OLM6 MN Histone deacetylase 4 (HDAC4) DM3OLM6 MT DTT DM3OLM6 MA Inhibitor DM3OLM6 RN Aromatic sulfide inhibitors of histone deacetylase based on arylsulfinyl-2,4-hexadienoic acid hydroxyamides. J Med Chem. 2006 Jan 26;49(2):800-5. DM3OLM6 RU https://pubmed.ncbi.nlm.nih.gov/16420064 DM3OLM6 DI DM3OLM6 DM3OLM6 DN 6-phenylsulfanylhexanoic acid hydroxamide DM3OLM6 MI TT5ZKDI DM3OLM6 MN Histone deacetylase 6 (HDAC6) DM3OLM6 MT DTT DM3OLM6 MA Inhibitor DM3OLM6 RN Aromatic sulfide inhibitors of histone deacetylase based on arylsulfinyl-2,4-hexadienoic acid hydroxyamides. J Med Chem. 2006 Jan 26;49(2):800-5. DM3OLM6 RU https://pubmed.ncbi.nlm.nih.gov/16420064 DM3OLM6 DI DM3OLM6 DM3OLM6 DN 6-phenylsulfanylhexanoic acid hydroxamide DM3OLM6 MI TTT6LFV DM3OLM6 MN Histone deacetylase 8 (HDAC8) DM3OLM6 MT DTT DM3OLM6 MA Inhibitor DM3OLM6 RN Aromatic sulfide inhibitors of histone deacetylase based on arylsulfinyl-2,4-hexadienoic acid hydroxyamides. J Med Chem. 2006 Jan 26;49(2):800-5. DM3OLM6 RU https://pubmed.ncbi.nlm.nih.gov/16420064 DM6GWRB DI DM6GWRB DM6GWRB DN 6-Phenylsulfanylmethyl-pteridine-2,4-diamine DM6GWRB MI TT9SL3Q DM6GWRB MN Polypeptide deformylase (PDF) DM6GWRB MT DTT DM6GWRB MA Inhibitor DM6GWRB RN Nonclassical 2,4-diamino-8-deazafolate analogues as inhibitors of dihydrofolate reductases from rat liver, Pneumocystis carinii, and Toxoplasma gon... J Med Chem. 1996 Apr 26;39(9):1836-45. DM6GWRB RU https://pubmed.ncbi.nlm.nih.gov/8627607 DME230I DI DME230I DME230I DN 6-phenyl-thieno[3,2-d]pyrimidin-4-ylamine DME230I MI TTJ3E9X DME230I MN Inhibitor of nuclear factor kappa-B kinase beta (IKKB) DME230I MT DTT DME230I MA Inhibitor DME230I RN Evolution of the thienopyridine class of inhibitors of IkappaB kinase-beta: part I: hit-to-lead strategies. J Med Chem. 2006 May 18;49(10):2898-908. DME230I RU https://pubmed.ncbi.nlm.nih.gov/16686533 DMB1QCY DI DMB1QCY DMB1QCY DN 6-Phosphogluconic Acid DMB1QCY MI TTZ3IFB DMB1QCY MN Phosphogluconate dehydrogenase (PGD) DMB1QCY MT DTT DMB1QCY MA Inhibitor DMB1QCY RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMB1QCY RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMIAQUC DI DMIAQUC DMIAQUC DN 6-p-Tolylamino-1H-pyrimidine-2,4-dione DMIAQUC MI TT2GPK3 DMIAQUC MN DNA topoisomerase (TOP) DMIAQUC MT DTT DMIAQUC MA Inhibitor DMIAQUC RN Inhibitors of Bacillus subtilis DNA polymerase III. 6-Anilinouracils and 6-(alkylamino)uracils. J Med Chem. 1980 Jan;23(1):34-8. DMIAQUC RU https://pubmed.ncbi.nlm.nih.gov/6767030 DM86XG5 DI DM86XG5 DM86XG5 DN 6-Pyridin-3-yl-1,2,3,4-tetrahydronaphthalen-2-ol DM86XG5 MI TTIQUX7 DM86XG5 MN Steroid 11-beta-hydroxylase (CYP11B1) DM86XG5 MT DTT DM86XG5 MA Inhibitor DM86XG5 RN In vivo active aldosterone synthase inhibitors with improved selectivity: lead optimization providing a series of pyridine substituted 3,4-dihydro-... J Med Chem. 2008 Dec 25;51(24):8077-87. DM86XG5 RU https://pubmed.ncbi.nlm.nih.gov/19049427 DMG5ABT DI DMG5ABT DMG5ABT DN 6-Pyridin-3-yl-3,4-dihydro-1H-quinolin-2-one DMG5ABT MI TT06AWU DMG5ABT MN Phosphodiesterase 3A (PDE3A) DMG5ABT MT DTT DMG5ABT MA Inhibitor DMG5ABT RN 3,4-Dihydroquinolin-2(1H)-ones as combined inhibitors of thromboxane A2 synthase and cAMP phosphodiesterase. J Med Chem. 1992 Feb 21;35(4):620-8. DMG5ABT RU https://pubmed.ncbi.nlm.nih.gov/1311763 DMG5ABT DI DMG5ABT DMG5ABT DN 6-Pyridin-3-yl-3,4-dihydro-1H-quinolin-2-one DMG5ABT MI TTIQUX7 DMG5ABT MN Steroid 11-beta-hydroxylase (CYP11B1) DMG5ABT MT DTT DMG5ABT MA Inhibitor DMG5ABT RN In vivo active aldosterone synthase inhibitors with improved selectivity: lead optimization providing a series of pyridine substituted 3,4-dihydro-... J Med Chem. 2008 Dec 25;51(24):8077-87. DMG5ABT RU https://pubmed.ncbi.nlm.nih.gov/19049427 DMIM5DL DI DMIM5DL DMIM5DL DN 6-Pyridin-3-yl-3,4-dihydronaphthalen-2(1H)-one DMIM5DL MI TTXV4FI DMIM5DL MN Albendazole monooxygenase (CYP3A4) DMIM5DL MT DTT DMIM5DL MA Inhibitor DMIM5DL RN In vivo active aldosterone synthase inhibitors with improved selectivity: lead optimization providing a series of pyridine substituted 3,4-dihydro-... J Med Chem. 2008 Dec 25;51(24):8077-87. DMIM5DL RU https://pubmed.ncbi.nlm.nih.gov/19049427 DMIM5DL DI DMIM5DL DMIM5DL DN 6-Pyridin-3-yl-3,4-dihydronaphthalen-2(1H)-one DMIM5DL MI TTIQUX7 DMIM5DL MN Steroid 11-beta-hydroxylase (CYP11B1) DMIM5DL MT DTT DMIM5DL MA Inhibitor DMIM5DL RN In vivo active aldosterone synthase inhibitors with improved selectivity: lead optimization providing a series of pyridine substituted 3,4-dihydro-... J Med Chem. 2008 Dec 25;51(24):8077-87. DMIM5DL RU https://pubmed.ncbi.nlm.nih.gov/19049427 DMHAS2B DI DMHAS2B DMHAS2B DN 6-Pyridin-3-yl-3,4-dihydroquinoline-2(1H)-thione DMHAS2B MI TTIQUX7 DMHAS2B MN Steroid 11-beta-hydroxylase (CYP11B1) DMHAS2B MT DTT DMHAS2B MA Inhibitor DMHAS2B RN In vivo active aldosterone synthase inhibitors with improved selectivity: lead optimization providing a series of pyridine substituted 3,4-dihydro-... J Med Chem. 2008 Dec 25;51(24):8077-87. DMHAS2B RU https://pubmed.ncbi.nlm.nih.gov/19049427 DMHAS2B DI DMHAS2B DMHAS2B DN 6-Pyridin-3-yl-3,4-dihydroquinoline-2(1H)-thione DMHAS2B MI TTRA5BZ DMHAS2B MN Steroid 17-alpha-monooxygenase (S17AH) DMHAS2B MT DTT DMHAS2B MA Inhibitor DMHAS2B RN In vivo active aldosterone synthase inhibitors with improved selectivity: lead optimization providing a series of pyridine substituted 3,4-dihydro-... J Med Chem. 2008 Dec 25;51(24):8077-87. DMHAS2B RU https://pubmed.ncbi.nlm.nih.gov/19049427 DMGWNDB DI DMGWNDB DMGWNDB DN 6-Pyridin-3-yl-naphthalen-2-ol DMGWNDB MI TTIQUX7 DMGWNDB MN Steroid 11-beta-hydroxylase (CYP11B1) DMGWNDB MT DTT DMGWNDB MA Inhibitor DMGWNDB RN Heteroaryl-substituted naphthalenes and structurally modified derivatives: selective inhibitors of CYP11B2 for the treatment of congestive heart fa... J Med Chem. 2005 Oct 20;48(21):6632-42. DMGWNDB RU https://pubmed.ncbi.nlm.nih.gov/16220979 DMGWNDB DI DMGWNDB DMGWNDB DN 6-Pyridin-3-yl-naphthalen-2-ol DMGWNDB MI TTRA5BZ DMGWNDB MN Steroid 17-alpha-monooxygenase (S17AH) DMGWNDB MT DTT DMGWNDB MA Inhibitor DMGWNDB RN Heteroaryl-substituted naphthalenes and structurally modified derivatives: selective inhibitors of CYP11B2 for the treatment of congestive heart fa... J Med Chem. 2005 Oct 20;48(21):6632-42. DMGWNDB RU https://pubmed.ncbi.nlm.nih.gov/16220979 DMIA7ND DI DMIA7ND DMIA7ND DN 6s-5,6,7,8-Tetrahydrobiopterin DMIA7ND MI TTCM4B3 DMIA7ND MN Nitric-oxide synthase endothelial (NOS3) DMIA7ND MT DTT DMIA7ND MA Inhibitor DMIA7ND RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMIA7ND RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMDO13Y DI DMDO13Y DMDO13Y DN 6-Styryl-naphthalene-2-carboxamidine DMDO13Y MI TT2WR1T DMDO13Y MN Cationic trypsinogen (PRSS1) DMDO13Y MT DTT DMDO13Y MA Inhibitor DMDO13Y RN Naphthamidine urokinase plasminogen activator inhibitors with improved pharmacokinetic properties. Bioorg Med Chem Lett. 2005 Jan 3;15(1):93-8. DMDO13Y RU https://pubmed.ncbi.nlm.nih.gov/15582418 DMQAG1B DI DMQAG1B DMQAG1B DN 6-tert-Butyl-2-morpholin-4-yl-4H-thiopyran-4-one DMQAG1B MI TTK3PY9 DMQAG1B MN DNA-dependent protein kinase catalytic (PRKDC) DMQAG1B MT DTT DMQAG1B MA Inhibitor DMQAG1B RN Pyranone, thiopyranone, and pyridone inhibitors of phosphatidylinositol 3-kinase related kinases. Structure-activity relationships for DNA-dependen... J Med Chem. 2007 Apr 19;50(8):1958-72. DMQAG1B RU https://pubmed.ncbi.nlm.nih.gov/17371003 DM9EA3C DI DM9EA3C DM9EA3C DN 6-tert-butyl-m-cresol DM9EA3C MI TT946IA DM9EA3C MN Transient receptor potential cation channel V3 (TRPV3) DM9EA3C MT DTT DM9EA3C MA Activator DM9EA3C RN Monoterpenoid agonists of TRPV3. Br J Pharmacol. 2007 Jun;151(4):530-40. DM9EA3C RU https://pubmed.ncbi.nlm.nih.gov/17420775 DMVGC7H DI DMVGC7H DMVGC7H DN 6-Thia-10b-aza-benzo[e]azulen-4-one DMVGC7H MI TTPTXIN DMVGC7H MN Translocator protein (TSPO) DMVGC7H MT DTT DMVGC7H MA Inhibitor DMVGC7H RN Novel ligands specific for mitochondrial benzodiazepine receptors: 6-arylpyrrolo[2,1-d][1,5]benzothiazepine derivatives. Synthesis, structure-activ... J Med Chem. 1994 May 13;37(10):1427-38. DMVGC7H RU https://pubmed.ncbi.nlm.nih.gov/8182701 DMC013U DI DMC013U DMC013U DN 6-Thiophen-2-yl-imidazo[2,1-b]thiazole DMC013U MI TTTJF7V DMC013U MN NADH dehydrogenase (MT-ND3) DMC013U MT DTT DMC013U MA Inhibitor DMC013U RN Thienylimidazo[2,1-b]thiazoles as inhibitors of mitochondrial NADH dehydrogenase. J Med Chem. 1995 Mar 31;38(7):1090-7. DMC013U RU https://pubmed.ncbi.nlm.nih.gov/7707312 DM90VJ6 DI DM90VJ6 DM90VJ6 DN 6-Thiophen-3-yl-imidazo[2,1-b]thiazole DM90VJ6 MI TTTJF7V DM90VJ6 MN NADH dehydrogenase (MT-ND3) DM90VJ6 MT DTT DM90VJ6 MA Inhibitor DM90VJ6 RN Thienylimidazo[2,1-b]thiazoles as inhibitors of mitochondrial NADH dehydrogenase. J Med Chem. 1995 Mar 31;38(7):1090-7. DM90VJ6 RU https://pubmed.ncbi.nlm.nih.gov/7707312 DMVL218 DI DMVL218 DMVL218 DN 6-tosyl-1,2,3,4,5,6-hexahydroazepino[4,5-b]indole DMVL218 MI TTJS8PY DMVL218 MN 5-HT 6 receptor (HTR6) DMVL218 MT DTT DMVL218 MA Inhibitor DMVL218 RN A regiospecific synthesis of a series of 1-sulfonyl azepinoindoles as potent 5-HT6 ligands. Bioorg Med Chem Lett. 2008 Jul 15;18(14):3929-31. DMVL218 RU https://pubmed.ncbi.nlm.nih.gov/18583130 DM2UTEA DI DM2UTEA DM2UTEA DN 7-((1H-imidazol-1-yl)methyl)-2H-chromen-2-one DM2UTEA MI TTSZLWK DM2UTEA MN Aromatase (CYP19A1) DM2UTEA MT DTT DM2UTEA MA Inhibitor DM2UTEA RN Fast three dimensional pharmacophore virtual screening of new potent non-steroid aromatase inhibitors. J Med Chem. 2009 Jan 8;52(1):143-50. DM2UTEA RU https://pubmed.ncbi.nlm.nih.gov/19072235 DMOS4ZQ DI DMOS4ZQ DMOS4ZQ DN 7-((1H-imidazol-1-yl)methyl)-4H-chromen-4-one DMOS4ZQ MI TTSZLWK DMOS4ZQ MN Aromatase (CYP19A1) DMOS4ZQ MT DTT DMOS4ZQ MA Inhibitor DMOS4ZQ RN Fast three dimensional pharmacophore virtual screening of new potent non-steroid aromatase inhibitors. J Med Chem. 2009 Jan 8;52(1):143-50. DMOS4ZQ RU https://pubmed.ncbi.nlm.nih.gov/19072235 DM9ID4T DI DM9ID4T DM9ID4T DN 7-((1H-imidazol-1-yl)methyl)isoquinoline DM9ID4T MI TTSZLWK DM9ID4T MN Aromatase (CYP19A1) DM9ID4T MT DTT DM9ID4T MA Inhibitor DM9ID4T RN Fast three dimensional pharmacophore virtual screening of new potent non-steroid aromatase inhibitors. J Med Chem. 2009 Jan 8;52(1):143-50. DM9ID4T RU https://pubmed.ncbi.nlm.nih.gov/19072235 DMRPFNU DI DMRPFNU DMRPFNU DN 7-(1-(1H-imidazol-1-yl)ethyl)-9H-fluoren-2-ol DMRPFNU MI TTIQUX7 DMRPFNU MN Steroid 11-beta-hydroxylase (CYP11B1) DMRPFNU MT DTT DMRPFNU MA Inhibitor DMRPFNU RN Synthesis, biological evaluation, and molecular modeling studies of methylene imidazole substituted biaryls as inhibitors of human 17alpha-hydroxyl... Bioorg Med Chem. 2008 Aug 15;16(16):7715-27. DMRPFNU RU https://pubmed.ncbi.nlm.nih.gov/18674917 DMRPFNU DI DMRPFNU DMRPFNU DN 7-(1-(1H-imidazol-1-yl)ethyl)-9H-fluoren-2-ol DMRPFNU MI TTRA5BZ DMRPFNU MN Steroid 17-alpha-monooxygenase (S17AH) DMRPFNU MT DTT DMRPFNU MA Inhibitor DMRPFNU RN Synthesis, biological evaluation, and molecular modeling studies of methylene imidazole substituted biaryls as inhibitors of human 17alpha-hydroxyl... Bioorg Med Chem. 2008 Aug 15;16(16):7715-27. DMRPFNU RU https://pubmed.ncbi.nlm.nih.gov/18674917 DMOZV9W DI DMOZV9W DMOZV9W DN 7-(1H-indol-5-yloxy)-N-hydroxyheptanamide DMOZV9W MI TT6R7JZ DMOZV9W MN Histone deacetylase 1 (HDAC1) DMOZV9W MT DTT DMOZV9W MA Inhibitor DMOZV9W RN Structure-activity relationships of aryloxyalkanoic acid hydroxyamides as potent inhibitors of histone deacetylase. Bioorg Med Chem Lett. 2007 Jan 1;17(1):136-41. DMOZV9W RU https://pubmed.ncbi.nlm.nih.gov/17046252 DM4HUO1 DI DM4HUO1 DM4HUO1 DN 7-(2-(1H-imidazol-1-yl)ethoxy)-2H-chromen-2-one DM4HUO1 MI TTSZLWK DM4HUO1 MN Aromatase (CYP19A1) DM4HUO1 MT DTT DM4HUO1 MA Inhibitor DM4HUO1 RN Design, synthesis, and 3D QSAR of novel potent and selective aromatase inhibitors. J Med Chem. 2004 Dec 30;47(27):6792-803. DM4HUO1 RU https://pubmed.ncbi.nlm.nih.gov/15615528 DMPV674 DI DMPV674 DMPV674 DN 7-(2-Amino-ethyl)-4-hydroxy-3H-benzothiazol-2-one DMPV674 MI TTEX248 DMPV674 MN Dopamine D2 receptor (D2R) DMPV674 MT DTT DMPV674 MA Inhibitor DMPV674 RN Synthesis and evaluation of non-catechol D-1 and D-2 dopamine receptor agonists: benzimidazol-2-one, benzoxazol-2-one, and the highly potent benzot... J Med Chem. 1987 Jul;30(7):1166-76. DMPV674 RU https://pubmed.ncbi.nlm.nih.gov/2955118 DMWXGLE DI DMWXGLE DMWXGLE DN 7-(2-Dipropylamino-ethyl)-3H-benzothiazol-2-one DMWXGLE MI TTEX248 DMWXGLE MN Dopamine D2 receptor (D2R) DMWXGLE MT DTT DMWXGLE MA Inhibitor DMWXGLE RN Synthesis and evaluation of non-catechol D-1 and D-2 dopamine receptor agonists: benzimidazol-2-one, benzoxazol-2-one, and the highly potent benzot... J Med Chem. 1987 Jul;30(7):1166-76. DMWXGLE RU https://pubmed.ncbi.nlm.nih.gov/2955118 DMBIY98 DI DMBIY98 DMBIY98 DN 7-(2-Hydroxyethyl)-3-O-rhamnosylicariin DMBIY98 MI TTJ0IQB DMBIY98 MN Phosphodiesterase 5A (PDE5A) DMBIY98 MT DTT DMBIY98 MA Inhibitor DMBIY98 RN Potent inhibition of human phosphodiesterase-5 by icariin derivatives. J Nat Prod. 2008 Sep;71(9):1513-7. DMBIY98 RU https://pubmed.ncbi.nlm.nih.gov/18778098 DMO8DYW DI DMO8DYW DMO8DYW DN 7-(2-methoxyphenyl)-2-methylquinoline DMO8DYW MI TTHS256 DMO8DYW MN Metabotropic glutamate receptor 5 (mGluR5) DMO8DYW MT DTT DMO8DYW MA Inhibitor DMO8DYW RN Rational design of 7-arylquinolines as non-competitive metabotropic glutamate receptor subtype 5 antagonists. Bioorg Med Chem Lett. 2007 Aug 15;17(16):4415-8. DMO8DYW RU https://pubmed.ncbi.nlm.nih.gov/17590335 DMK28IS DI DMK28IS DMK28IS DN 7-(2-Nitro-ethyl)-azepan-(2Z)-ylideneamine DMK28IS MI TTZUFI5 DMK28IS MN Nitric-oxide synthase brain (NOS1) DMK28IS MT DTT DMK28IS MA Inhibitor DMK28IS RN Selective heterocyclic amidine inhibitors of human inducible nitric oxide synthase. Bioorg Med Chem Lett. 2001 Oct 8;11(19):2651-3. DMK28IS RU https://pubmed.ncbi.nlm.nih.gov/11551770 DMK28IS DI DMK28IS DMK28IS DN 7-(2-Nitro-ethyl)-azepan-(2Z)-ylideneamine DMK28IS MI TTCM4B3 DMK28IS MN Nitric-oxide synthase endothelial (NOS3) DMK28IS MT DTT DMK28IS MA Inhibitor DMK28IS RN Selective heterocyclic amidine inhibitors of human inducible nitric oxide synthase. Bioorg Med Chem Lett. 2001 Oct 8;11(19):2651-3. DMK28IS RU https://pubmed.ncbi.nlm.nih.gov/11551770 DMK28IS DI DMK28IS DMK28IS DN 7-(2-Nitro-ethyl)-azepan-(2Z)-ylideneamine DMK28IS MI TTF10I9 DMK28IS MN Nitric-oxide synthase inducible (NOS2) DMK28IS MT DTT DMK28IS MA Inhibitor DMK28IS RN Selective heterocyclic amidine inhibitors of human inducible nitric oxide synthase. Bioorg Med Chem Lett. 2001 Oct 8;11(19):2651-3. DMK28IS RU https://pubmed.ncbi.nlm.nih.gov/11551770 DMYNLOI DI DMYNLOI DMYNLOI DN 7-(3-(methoxymethyl)phenyl)-2-methylquinoline DMYNLOI MI TTHS256 DMYNLOI MN Metabotropic glutamate receptor 5 (mGluR5) DMYNLOI MT DTT DMYNLOI MA Inhibitor DMYNLOI RN Rational design of 7-arylquinolines as non-competitive metabotropic glutamate receptor subtype 5 antagonists. Bioorg Med Chem Lett. 2007 Aug 15;17(16):4415-8. DMYNLOI RU https://pubmed.ncbi.nlm.nih.gov/17590335 DM9BS5L DI DM9BS5L DM9BS5L DN 7-(3,5-dihydroxyphenyl)naphthalene-1,3-diol DM9BS5L MI TTULVH8 DM9BS5L MN Tyrosinase (TYR) DM9BS5L MT DTT DM9BS5L MA Inhibitor DM9BS5L RN Syntheses of hydroxy substituted 2-phenyl-naphthalenes as inhibitors of tyrosinase. Bioorg Med Chem Lett. 2007 Jan 15;17(2):461-4. DM9BS5L RU https://pubmed.ncbi.nlm.nih.gov/17064896 DM2RFOB DI DM2RFOB DM2RFOB DN 7-(3,5-dimethoxyphenyl)-1,6-naphthyridine DM2RFOB MI TTHS256 DM2RFOB MN Metabotropic glutamate receptor 5 (mGluR5) DM2RFOB MT DTT DM2RFOB MA Inhibitor DM2RFOB RN Synthesis and SAR comparison of regioisomeric aryl naphthyridines as potent mGlu5 receptor antagonists. Bioorg Med Chem Lett. 2007 Dec 1;17(23):6525-8. DM2RFOB RU https://pubmed.ncbi.nlm.nih.gov/17936624 DMNQW2B DI DMNQW2B DMNQW2B DN 7-(3,6,9,12-tetraoxatricos-22-enyl)theophylline DMNQW2B MI TTK25J1 DMNQW2B MN Adenosine A1 receptor (ADORA1) DMNQW2B MT DTT DMNQW2B MA Inhibitor DMNQW2B RN Synthesis of theophylline derivatives and study of their activity as antagonists at adenosine receptors. Bioorg Med Chem. 2010 Mar 15;18(6):2081-2088. DMNQW2B RU https://pubmed.ncbi.nlm.nih.gov/20202853 DMCFV0X DI DMCFV0X DMCFV0X DN 7-(3-Benzoyl-ureido)-heptanoic acid hydroxyamide DMCFV0X MI TT6R7JZ DMCFV0X MN Histone deacetylase 1 (HDAC1) DMCFV0X MT DTT DMCFV0X MA Inhibitor DMCFV0X RN Acylurea connected straight chain hydroxamates as novel histone deacetylase inhibitors: Synthesis, SAR, and in vivo antitumor activity. Bioorg Med Chem Lett. 2010 Jun 1;20(11):3314-21. DMCFV0X RU https://pubmed.ncbi.nlm.nih.gov/20451378 DM762G3 DI DM762G3 DM762G3 DN 7-(3-chlorobenzyloxy)-4-carboxaldehyde-coumarin DM762G3 MI TT3WG5C DM762G3 MN Monoamine oxidase type A (MAO-A) DM762G3 MT DTT DM762G3 MA Inhibitor DM762G3 RN Structures of human monoamine oxidase B complexes with selective noncovalent inhibitors: safinamide and coumarin analogs. J Med Chem. 2007 Nov 15;50(23):5848-52. DM762G3 RU https://pubmed.ncbi.nlm.nih.gov/17915852 DM762G3 DI DM762G3 DM762G3 DN 7-(3-chlorobenzyloxy)-4-carboxaldehyde-coumarin DM762G3 MI TTGP7BY DM762G3 MN Monoamine oxidase type B (MAO-B) DM762G3 MT DTT DM762G3 MA Inhibitor DM762G3 RN Structures of human monoamine oxidase B complexes with selective noncovalent inhibitors: safinamide and coumarin analogs. J Med Chem. 2007 Nov 15;50(23):5848-52. DM762G3 RU https://pubmed.ncbi.nlm.nih.gov/17915852 DM0Q56N DI DM0Q56N DM0Q56N DN 7-(3-chlorophenyl)-2-methylquinoline DM0Q56N MI TTHS256 DM0Q56N MN Metabotropic glutamate receptor 5 (mGluR5) DM0Q56N MT DTT DM0Q56N MA Inhibitor DM0Q56N RN Rational design of 7-arylquinolines as non-competitive metabotropic glutamate receptor subtype 5 antagonists. Bioorg Med Chem Lett. 2007 Aug 15;17(16):4415-8. DM0Q56N RU https://pubmed.ncbi.nlm.nih.gov/17590335 DME2VD7 DI DME2VD7 DME2VD7 DN 7-(3-fluoro-5-methylphenyl)-1,6-naphthyridine DME2VD7 MI TTHS256 DME2VD7 MN Metabotropic glutamate receptor 5 (mGluR5) DME2VD7 MT DTT DME2VD7 MA Inhibitor DME2VD7 RN Synthesis and SAR comparison of regioisomeric aryl naphthyridines as potent mGlu5 receptor antagonists. Bioorg Med Chem Lett. 2007 Dec 1;17(23):6525-8. DME2VD7 RU https://pubmed.ncbi.nlm.nih.gov/17936624 DMDXOBH DI DMDXOBH DMDXOBH DN 7-(3-fluorophenyl)-2-methylquinoline DMDXOBH MI TTHS256 DMDXOBH MN Metabotropic glutamate receptor 5 (mGluR5) DMDXOBH MT DTT DMDXOBH MA Inhibitor DMDXOBH RN Rational design of 7-arylquinolines as non-competitive metabotropic glutamate receptor subtype 5 antagonists. Bioorg Med Chem Lett. 2007 Aug 15;17(16):4415-8. DMDXOBH RU https://pubmed.ncbi.nlm.nih.gov/17590335 DM2I91C DI DM2I91C DM2I91C DN 7-(3-Hydroxy-phenyl)-naphthalen-2-ol DM2I91C MI TTIWB6L DM2I91C MN Estradiol 17 beta-dehydrogenase 1 (17-beta-HSD1) DM2I91C MT DTT DM2I91C MA Inhibitor DM2I91C RN Design, synthesis, and biological evaluation of (hydroxyphenyl)naphthalene and -quinoline derivatives: potent and selective nonsteroidal inhibitors... J Med Chem. 2008 Apr 10;51(7):2158-69. DM2I91C RU https://pubmed.ncbi.nlm.nih.gov/18324762 DM2I91C DI DM2I91C DM2I91C DN 7-(3-Hydroxy-phenyl)-naphthalen-2-ol DM2I91C MI TTZAYWL DM2I91C MN Estrogen receptor (ESR) DM2I91C MT DTT DM2I91C MA Inhibitor DM2I91C RN ERbeta ligands. 3. Exploiting two binding orientations of the 2-phenylnaphthalene scaffold to achieve ERbeta selectivity. J Med Chem. 2005 Jun 16;48(12):3953-79. DM2I91C RU https://pubmed.ncbi.nlm.nih.gov/15943471 DM2I91C DI DM2I91C DM2I91C DN 7-(3-Hydroxy-phenyl)-naphthalen-2-ol DM2I91C MI TTOM3J0 DM2I91C MN Estrogen receptor beta (ESR2) DM2I91C MT DTT DM2I91C MA Inhibitor DM2I91C RN ERbeta ligands. 3. Exploiting two binding orientations of the 2-phenylnaphthalene scaffold to achieve ERbeta selectivity. J Med Chem. 2005 Jun 16;48(12):3953-79. DM2I91C RU https://pubmed.ncbi.nlm.nih.gov/15943471 DMEC9YK DI DMEC9YK DMEC9YK DN 7-(3-methoxyphenyl)-2-methyl-1,6-naphthyridine DMEC9YK MI TTHS256 DMEC9YK MN Metabotropic glutamate receptor 5 (mGluR5) DMEC9YK MT DTT DMEC9YK MA Inhibitor DMEC9YK RN Synthesis and SAR comparison of regioisomeric aryl naphthyridines as potent mGlu5 receptor antagonists. Bioorg Med Chem Lett. 2007 Dec 1;17(23):6525-8. DMEC9YK RU https://pubmed.ncbi.nlm.nih.gov/17936624 DMW6LCH DI DMW6LCH DMW6LCH DN 7-(3-methoxyphenyl)-2-methylquinoline DMW6LCH MI TTHS256 DMW6LCH MN Metabotropic glutamate receptor 5 (mGluR5) DMW6LCH MT DTT DMW6LCH MA Inhibitor DMW6LCH RN Rational design of 7-arylquinolines as non-competitive metabotropic glutamate receptor subtype 5 antagonists. Bioorg Med Chem Lett. 2007 Aug 15;17(16):4415-8. DMW6LCH RU https://pubmed.ncbi.nlm.nih.gov/17590335 DM2TNCK DI DM2TNCK DM2TNCK DN 7-(4-(dimethylamino)phenoxy)-N-hydroxyheptanamide DM2TNCK MI TT6R7JZ DM2TNCK MN Histone deacetylase 1 (HDAC1) DM2TNCK MT DTT DM2TNCK MA Inhibitor DM2TNCK RN Structure-activity relationships of aryloxyalkanoic acid hydroxyamides as potent inhibitors of histone deacetylase. Bioorg Med Chem Lett. 2007 Jan 1;17(1):136-41. DM2TNCK RU https://pubmed.ncbi.nlm.nih.gov/17046252 DMHXMY5 DI DMHXMY5 DMHXMY5 DN 7-(4,6-dimethoxypyrimidin-2-yl)-2-methylquinoline DMHXMY5 MI TTHS256 DMHXMY5 MN Metabotropic glutamate receptor 5 (mGluR5) DMHXMY5 MT DTT DMHXMY5 MA Inhibitor DMHXMY5 RN Discovery of heterobicyclic templates for novel metabotropic glutamate receptor subtype 5 antagonists. Bioorg Med Chem Lett. 2007 Jun 1;17(11):2987-91. DMHXMY5 RU https://pubmed.ncbi.nlm.nih.gov/17446071 DMQFBTW DI DMQFBTW DMQFBTW DN 7-(4,6-dimethylpyrimidin-2-yl)-2-methylquinoline DMQFBTW MI TTHS256 DMQFBTW MN Metabotropic glutamate receptor 5 (mGluR5) DMQFBTW MT DTT DMQFBTW MA Inhibitor DMQFBTW RN Discovery of heterobicyclic templates for novel metabotropic glutamate receptor subtype 5 antagonists. Bioorg Med Chem Lett. 2007 Jun 1;17(11):2987-91. DMQFBTW RU https://pubmed.ncbi.nlm.nih.gov/17446071 DMM9IXB DI DMM9IXB DMM9IXB DN 7-(4-Hydroxy-phenyl)-naphthalen-2-ol DMM9IXB MI TTZAYWL DMM9IXB MN Estrogen receptor (ESR) DMM9IXB MT DTT DMM9IXB MA Inhibitor DMM9IXB RN ERbeta ligands. 3. Exploiting two binding orientations of the 2-phenylnaphthalene scaffold to achieve ERbeta selectivity. J Med Chem. 2005 Jun 16;48(12):3953-79. DMM9IXB RU https://pubmed.ncbi.nlm.nih.gov/15943471 DMM9IXB DI DMM9IXB DMM9IXB DN 7-(4-Hydroxy-phenyl)-naphthalen-2-ol DMM9IXB MI TTOM3J0 DMM9IXB MN Estrogen receptor beta (ESR2) DMM9IXB MT DTT DMM9IXB MA Inhibitor DMM9IXB RN ERbeta ligands. 3. Exploiting two binding orientations of the 2-phenylnaphthalene scaffold to achieve ERbeta selectivity. J Med Chem. 2005 Jun 16;48(12):3953-79. DMM9IXB RU https://pubmed.ncbi.nlm.nih.gov/15943471 DMBT1KS DI DMBT1KS DMBT1KS DN 7-(4-methoxyphenyl)-2-methylquinoline DMBT1KS MI TTHS256 DMBT1KS MN Metabotropic glutamate receptor 5 (mGluR5) DMBT1KS MT DTT DMBT1KS MA Inhibitor DMBT1KS RN Rational design of 7-arylquinolines as non-competitive metabotropic glutamate receptor subtype 5 antagonists. Bioorg Med Chem Lett. 2007 Aug 15;17(16):4415-8. DMBT1KS RU https://pubmed.ncbi.nlm.nih.gov/17590335 DMLIYUJ DI DMLIYUJ DMLIYUJ DN 7-(4-methoxyphenyl)pteridine-2,4-diol DMLIYUJ MI TTGX0HR DMLIYUJ MN Bacterial DNA ligase (Bact ligA) DMLIYUJ MT DTT DMLIYUJ MA Inhibitor DMLIYUJ RN Identification and validation of human DNA ligase inhibitors using computer-aided drug design. J Med Chem. 2008 Aug 14;51(15):4553-62. DMLIYUJ RU https://pubmed.ncbi.nlm.nih.gov/18630893 DMSRKF0 DI DMSRKF0 DMSRKF0 DN 7-(4-methoxypyrimidin-2-yl)-2-methylquinoline DMSRKF0 MI TTHS256 DMSRKF0 MN Metabotropic glutamate receptor 5 (mGluR5) DMSRKF0 MT DTT DMSRKF0 MA Inhibitor DMSRKF0 RN Discovery of heterobicyclic templates for novel metabotropic glutamate receptor subtype 5 antagonists. Bioorg Med Chem Lett. 2007 Jun 1;17(11):2987-91. DMSRKF0 RU https://pubmed.ncbi.nlm.nih.gov/17446071 DMTKFPW DI DMTKFPW DMTKFPW DN 7-(benzyloxy)-2H-chromen-2-one DMTKFPW MI TTUNARX DMTKFPW MN Carbonic anhydrase (CA) DMTKFPW MT DTT DMTKFPW MA Inhibitor DMTKFPW RN Deciphering the mechanism of carbonic anhydrase inhibition with coumarins and thiocoumarins. J Med Chem. 2010 Jan 14;53(1):335-44. DMTKFPW RU https://pubmed.ncbi.nlm.nih.gov/19911821 DMTKFPW DI DMTKFPW DMTKFPW DN 7-(benzyloxy)-2H-chromen-2-one DMTKFPW MI TTZHA0O DMTKFPW MN Carbonic anhydrase IV (CA-IV) DMTKFPW MT DTT DMTKFPW MA Inhibitor DMTKFPW RN Deciphering the mechanism of carbonic anhydrase inhibition with coumarins and thiocoumarins. J Med Chem. 2010 Jan 14;53(1):335-44. DMTKFPW RU https://pubmed.ncbi.nlm.nih.gov/19911821 DMTKFPW DI DMTKFPW DMTKFPW DN 7-(benzyloxy)-2H-chromen-2-one DMTKFPW MI TT2LVK8 DMTKFPW MN Carbonic anhydrase IX (CA-IX) DMTKFPW MT DTT DMTKFPW MA Inhibitor DMTKFPW RN Deciphering the mechanism of carbonic anhydrase inhibition with coumarins and thiocoumarins. J Med Chem. 2010 Jan 14;53(1):335-44. DMTKFPW RU https://pubmed.ncbi.nlm.nih.gov/19911821 DMTKFPW DI DMTKFPW DMTKFPW DN 7-(benzyloxy)-2H-chromen-2-one DMTKFPW MI TTSYM0R DMTKFPW MN Carbonic anhydrase XII (CA-XII) DMTKFPW MT DTT DMTKFPW MA Inhibitor DMTKFPW RN Deciphering the mechanism of carbonic anhydrase inhibition with coumarins and thiocoumarins. J Med Chem. 2010 Jan 14;53(1):335-44. DMTKFPW RU https://pubmed.ncbi.nlm.nih.gov/19911821 DMTKFPW DI DMTKFPW DMTKFPW DN 7-(benzyloxy)-2H-chromen-2-one DMTKFPW MI TTEYTKG DMTKFPW MN Carbonic anhydrase XIV (CA-XIV) DMTKFPW MT DTT DMTKFPW MA Inhibitor DMTKFPW RN Deciphering the mechanism of carbonic anhydrase inhibition with coumarins and thiocoumarins. J Med Chem. 2010 Jan 14;53(1):335-44. DMTKFPW RU https://pubmed.ncbi.nlm.nih.gov/19911821 DMLCGSY DI DMLCGSY DMLCGSY DN 7-(Biphenyl-3-yloxy)-1-oxazol-2-yl-heptan-1-one DMLCGSY MI TTBH0VX DMLCGSY MN Histone deacetylase (HDAC) DMLCGSY MT DTT DMLCGSY MA Inhibitor DMLCGSY RN Heterocyclic ketones as inhibitors of histone deacetylase. Bioorg Med Chem Lett. 2003 Nov 17;13(22):3909-13. DMLCGSY RU https://pubmed.ncbi.nlm.nih.gov/14592473 DMLCGSY DI DMLCGSY DMLCGSY DN 7-(Biphenyl-3-yloxy)-1-oxazol-2-yl-heptan-1-one DMLCGSY MI TT6R7JZ DMLCGSY MN Histone deacetylase 1 (HDAC1) DMLCGSY MT DTT DMLCGSY MA Inhibitor DMLCGSY RN Heterocyclic ketones as inhibitors of histone deacetylase. Bioorg Med Chem Lett. 2003 Nov 17;13(22):3909-13. DMLCGSY RU https://pubmed.ncbi.nlm.nih.gov/14592473 DMLCGSY DI DMLCGSY DMLCGSY DN 7-(Biphenyl-3-yloxy)-1-oxazol-2-yl-heptan-1-one DMLCGSY MI TTYHPU6 DMLCGSY MN Histone deacetylase 10 (HDAC10) DMLCGSY MT DTT DMLCGSY MA Inhibitor DMLCGSY RN Heterocyclic ketones as inhibitors of histone deacetylase. Bioorg Med Chem Lett. 2003 Nov 17;13(22):3909-13. DMLCGSY RU https://pubmed.ncbi.nlm.nih.gov/14592473 DMLCGSY DI DMLCGSY DMLCGSY DN 7-(Biphenyl-3-yloxy)-1-oxazol-2-yl-heptan-1-one DMLCGSY MI TTSHTOI DMLCGSY MN Histone deacetylase 2 (HDAC2) DMLCGSY MT DTT DMLCGSY MA Inhibitor DMLCGSY RN Heterocyclic ketones as inhibitors of histone deacetylase. Bioorg Med Chem Lett. 2003 Nov 17;13(22):3909-13. DMLCGSY RU https://pubmed.ncbi.nlm.nih.gov/14592473 DMLCGSY DI DMLCGSY DMLCGSY DN 7-(Biphenyl-3-yloxy)-1-oxazol-2-yl-heptan-1-one DMLCGSY MI TTTQGH8 DMLCGSY MN Histone deacetylase 4 (HDAC4) DMLCGSY MT DTT DMLCGSY MA Inhibitor DMLCGSY RN Heterocyclic ketones as inhibitors of histone deacetylase. Bioorg Med Chem Lett. 2003 Nov 17;13(22):3909-13. DMLCGSY RU https://pubmed.ncbi.nlm.nih.gov/14592473 DMLCGSY DI DMLCGSY DMLCGSY DN 7-(Biphenyl-3-yloxy)-1-oxazol-2-yl-heptan-1-one DMLCGSY MI TT5ZKDI DMLCGSY MN Histone deacetylase 6 (HDAC6) DMLCGSY MT DTT DMLCGSY MA Inhibitor DMLCGSY RN Heterocyclic ketones as inhibitors of histone deacetylase. Bioorg Med Chem Lett. 2003 Nov 17;13(22):3909-13. DMLCGSY RU https://pubmed.ncbi.nlm.nih.gov/14592473 DMLCGSY DI DMLCGSY DMLCGSY DN 7-(Biphenyl-3-yloxy)-1-oxazol-2-yl-heptan-1-one DMLCGSY MI TTT6LFV DMLCGSY MN Histone deacetylase 8 (HDAC8) DMLCGSY MT DTT DMLCGSY MA Inhibitor DMLCGSY RN Heterocyclic ketones as inhibitors of histone deacetylase. Bioorg Med Chem Lett. 2003 Nov 17;13(22):3909-13. DMLCGSY RU https://pubmed.ncbi.nlm.nih.gov/14592473 DM28GZ7 DI DM28GZ7 DM28GZ7 DN 7-(Biphenyl-4-yloxy)-1,1,1-trifluoro-heptan-2-one DM28GZ7 MI TTBH0VX DM28GZ7 MN Histone deacetylase (HDAC) DM28GZ7 MT DTT DM28GZ7 MA Inhibitor DM28GZ7 RN Histone deacetylase inhibitors. J Med Chem. 2003 Nov 20;46(24):5097-116. DM28GZ7 RU https://pubmed.ncbi.nlm.nih.gov/14613312 DM28GZ7 DI DM28GZ7 DM28GZ7 DN 7-(Biphenyl-4-yloxy)-1,1,1-trifluoro-heptan-2-one DM28GZ7 MI TT6R7JZ DM28GZ7 MN Histone deacetylase 1 (HDAC1) DM28GZ7 MT DTT DM28GZ7 MA Inhibitor DM28GZ7 RN Trifluoromethyl ketones as inhibitors of histone deacetylase. Bioorg Med Chem Lett. 2002 Dec 2;12(23):3443-7. DM28GZ7 RU https://pubmed.ncbi.nlm.nih.gov/12419380 DM28GZ7 DI DM28GZ7 DM28GZ7 DN 7-(Biphenyl-4-yloxy)-1,1,1-trifluoro-heptan-2-one DM28GZ7 MI TTYHPU6 DM28GZ7 MN Histone deacetylase 10 (HDAC10) DM28GZ7 MT DTT DM28GZ7 MA Inhibitor DM28GZ7 RN Histone deacetylase inhibitors. J Med Chem. 2003 Nov 20;46(24):5097-116. DM28GZ7 RU https://pubmed.ncbi.nlm.nih.gov/14613312 DM28GZ7 DI DM28GZ7 DM28GZ7 DN 7-(Biphenyl-4-yloxy)-1,1,1-trifluoro-heptan-2-one DM28GZ7 MI TTSHTOI DM28GZ7 MN Histone deacetylase 2 (HDAC2) DM28GZ7 MT DTT DM28GZ7 MA Inhibitor DM28GZ7 RN Trifluoromethyl ketones as inhibitors of histone deacetylase. Bioorg Med Chem Lett. 2002 Dec 2;12(23):3443-7. DM28GZ7 RU https://pubmed.ncbi.nlm.nih.gov/12419380 DM28GZ7 DI DM28GZ7 DM28GZ7 DN 7-(Biphenyl-4-yloxy)-1,1,1-trifluoro-heptan-2-one DM28GZ7 MI TTTQGH8 DM28GZ7 MN Histone deacetylase 4 (HDAC4) DM28GZ7 MT DTT DM28GZ7 MA Inhibitor DM28GZ7 RN Histone deacetylase inhibitors. J Med Chem. 2003 Nov 20;46(24):5097-116. DM28GZ7 RU https://pubmed.ncbi.nlm.nih.gov/14613312 DM28GZ7 DI DM28GZ7 DM28GZ7 DN 7-(Biphenyl-4-yloxy)-1,1,1-trifluoro-heptan-2-one DM28GZ7 MI TT5ZKDI DM28GZ7 MN Histone deacetylase 6 (HDAC6) DM28GZ7 MT DTT DM28GZ7 MA Inhibitor DM28GZ7 RN Histone deacetylase inhibitors. J Med Chem. 2003 Nov 20;46(24):5097-116. DM28GZ7 RU https://pubmed.ncbi.nlm.nih.gov/14613312 DM28GZ7 DI DM28GZ7 DM28GZ7 DN 7-(Biphenyl-4-yloxy)-1,1,1-trifluoro-heptan-2-one DM28GZ7 MI TTT6LFV DM28GZ7 MN Histone deacetylase 8 (HDAC8) DM28GZ7 MT DTT DM28GZ7 MA Inhibitor DM28GZ7 RN Histone deacetylase inhibitors. J Med Chem. 2003 Nov 20;46(24):5097-116. DM28GZ7 RU https://pubmed.ncbi.nlm.nih.gov/14613312 DMY027P DI DMY027P DMY027P DN 7-(Biphenyl-4-yloxy)-1-oxazol-2-yl-heptan-1-one DMY027P MI TTBH0VX DMY027P MN Histone deacetylase (HDAC) DMY027P MT DTT DMY027P MA Inhibitor DMY027P RN Heterocyclic ketones as inhibitors of histone deacetylase. Bioorg Med Chem Lett. 2003 Nov 17;13(22):3909-13. DMY027P RU https://pubmed.ncbi.nlm.nih.gov/14592473 DMY027P DI DMY027P DMY027P DN 7-(Biphenyl-4-yloxy)-1-oxazol-2-yl-heptan-1-one DMY027P MI TT6R7JZ DMY027P MN Histone deacetylase 1 (HDAC1) DMY027P MT DTT DMY027P MA Inhibitor DMY027P RN Heterocyclic ketones as inhibitors of histone deacetylase. Bioorg Med Chem Lett. 2003 Nov 17;13(22):3909-13. DMY027P RU https://pubmed.ncbi.nlm.nih.gov/14592473 DMY027P DI DMY027P DMY027P DN 7-(Biphenyl-4-yloxy)-1-oxazol-2-yl-heptan-1-one DMY027P MI TTYHPU6 DMY027P MN Histone deacetylase 10 (HDAC10) DMY027P MT DTT DMY027P MA Inhibitor DMY027P RN Heterocyclic ketones as inhibitors of histone deacetylase. Bioorg Med Chem Lett. 2003 Nov 17;13(22):3909-13. DMY027P RU https://pubmed.ncbi.nlm.nih.gov/14592473 DMY027P DI DMY027P DMY027P DN 7-(Biphenyl-4-yloxy)-1-oxazol-2-yl-heptan-1-one DMY027P MI TTSHTOI DMY027P MN Histone deacetylase 2 (HDAC2) DMY027P MT DTT DMY027P MA Inhibitor DMY027P RN Heterocyclic ketones as inhibitors of histone deacetylase. Bioorg Med Chem Lett. 2003 Nov 17;13(22):3909-13. DMY027P RU https://pubmed.ncbi.nlm.nih.gov/14592473 DMY027P DI DMY027P DMY027P DN 7-(Biphenyl-4-yloxy)-1-oxazol-2-yl-heptan-1-one DMY027P MI TTTQGH8 DMY027P MN Histone deacetylase 4 (HDAC4) DMY027P MT DTT DMY027P MA Inhibitor DMY027P RN Heterocyclic ketones as inhibitors of histone deacetylase. Bioorg Med Chem Lett. 2003 Nov 17;13(22):3909-13. DMY027P RU https://pubmed.ncbi.nlm.nih.gov/14592473 DMY027P DI DMY027P DMY027P DN 7-(Biphenyl-4-yloxy)-1-oxazol-2-yl-heptan-1-one DMY027P MI TT5ZKDI DMY027P MN Histone deacetylase 6 (HDAC6) DMY027P MT DTT DMY027P MA Inhibitor DMY027P RN Heterocyclic ketones as inhibitors of histone deacetylase. Bioorg Med Chem Lett. 2003 Nov 17;13(22):3909-13. DMY027P RU https://pubmed.ncbi.nlm.nih.gov/14592473 DMY027P DI DMY027P DMY027P DN 7-(Biphenyl-4-yloxy)-1-oxazol-2-yl-heptan-1-one DMY027P MI TTT6LFV DMY027P MN Histone deacetylase 8 (HDAC8) DMY027P MT DTT DMY027P MA Inhibitor DMY027P RN Heterocyclic ketones as inhibitors of histone deacetylase. Bioorg Med Chem Lett. 2003 Nov 17;13(22):3909-13. DMY027P RU https://pubmed.ncbi.nlm.nih.gov/14592473 DMO4YLA DI DMO4YLA DMO4YLA DN 7-(Biphenyl-4-yloxy)-heptanoic acid hydroxyamide DMO4YLA MI TT6R7JZ DMO4YLA MN Histone deacetylase 1 (HDAC1) DMO4YLA MT DTT DMO4YLA MA Inhibitor DMO4YLA RN Alpha-keto amides as inhibitors of histone deacetylase. Bioorg Med Chem Lett. 2003 Oct 6;13(19):3331-5. DMO4YLA RU https://pubmed.ncbi.nlm.nih.gov/12951120 DMO4YLA DI DMO4YLA DMO4YLA DN 7-(Biphenyl-4-yloxy)-heptanoic acid hydroxyamide DMO4YLA MI TTSHTOI DMO4YLA MN Histone deacetylase 2 (HDAC2) DMO4YLA MT DTT DMO4YLA MA Inhibitor DMO4YLA RN Alpha-keto amides as inhibitors of histone deacetylase. Bioorg Med Chem Lett. 2003 Oct 6;13(19):3331-5. DMO4YLA RU https://pubmed.ncbi.nlm.nih.gov/12951120 DMU74R8 DI DMU74R8 DMU74R8 DN 7-(naphthalen-2-yl)benzo[e][1,2,4]triazin-3-amine DMU74R8 MI TT6PKBN DMU74R8 MN Proto-oncogene c-Src (SRC) DMU74R8 MT DTT DMU74R8 MA Inhibitor DMU74R8 RN Discovery and preliminary structure-activity relationship studies of novel benzotriazine based compounds as Src inhibitors. Bioorg Med Chem Lett. 2006 Nov 1;16(21):5546-50. DMU74R8 RU https://pubmed.ncbi.nlm.nih.gov/16931012 DM4VQN8 DI DM4VQN8 DM4VQN8 DN 7-(Naphthalen-2-yloxy)-1-oxazol-2-yl-heptan-1-one DM4VQN8 MI TTBH0VX DM4VQN8 MN Histone deacetylase (HDAC) DM4VQN8 MT DTT DM4VQN8 MA Inhibitor DM4VQN8 RN Heterocyclic ketones as inhibitors of histone deacetylase. Bioorg Med Chem Lett. 2003 Nov 17;13(22):3909-13. DM4VQN8 RU https://pubmed.ncbi.nlm.nih.gov/14592473 DM4VQN8 DI DM4VQN8 DM4VQN8 DN 7-(Naphthalen-2-yloxy)-1-oxazol-2-yl-heptan-1-one DM4VQN8 MI TT6R7JZ DM4VQN8 MN Histone deacetylase 1 (HDAC1) DM4VQN8 MT DTT DM4VQN8 MA Inhibitor DM4VQN8 RN Heterocyclic ketones as inhibitors of histone deacetylase. Bioorg Med Chem Lett. 2003 Nov 17;13(22):3909-13. DM4VQN8 RU https://pubmed.ncbi.nlm.nih.gov/14592473 DM4VQN8 DI DM4VQN8 DM4VQN8 DN 7-(Naphthalen-2-yloxy)-1-oxazol-2-yl-heptan-1-one DM4VQN8 MI TTYHPU6 DM4VQN8 MN Histone deacetylase 10 (HDAC10) DM4VQN8 MT DTT DM4VQN8 MA Inhibitor DM4VQN8 RN Heterocyclic ketones as inhibitors of histone deacetylase. Bioorg Med Chem Lett. 2003 Nov 17;13(22):3909-13. DM4VQN8 RU https://pubmed.ncbi.nlm.nih.gov/14592473 DM4VQN8 DI DM4VQN8 DM4VQN8 DN 7-(Naphthalen-2-yloxy)-1-oxazol-2-yl-heptan-1-one DM4VQN8 MI TTSHTOI DM4VQN8 MN Histone deacetylase 2 (HDAC2) DM4VQN8 MT DTT DM4VQN8 MA Inhibitor DM4VQN8 RN Heterocyclic ketones as inhibitors of histone deacetylase. Bioorg Med Chem Lett. 2003 Nov 17;13(22):3909-13. DM4VQN8 RU https://pubmed.ncbi.nlm.nih.gov/14592473 DM4VQN8 DI DM4VQN8 DM4VQN8 DN 7-(Naphthalen-2-yloxy)-1-oxazol-2-yl-heptan-1-one DM4VQN8 MI TTTQGH8 DM4VQN8 MN Histone deacetylase 4 (HDAC4) DM4VQN8 MT DTT DM4VQN8 MA Inhibitor DM4VQN8 RN Heterocyclic ketones as inhibitors of histone deacetylase. Bioorg Med Chem Lett. 2003 Nov 17;13(22):3909-13. DM4VQN8 RU https://pubmed.ncbi.nlm.nih.gov/14592473 DM4VQN8 DI DM4VQN8 DM4VQN8 DN 7-(Naphthalen-2-yloxy)-1-oxazol-2-yl-heptan-1-one DM4VQN8 MI TT5ZKDI DM4VQN8 MN Histone deacetylase 6 (HDAC6) DM4VQN8 MT DTT DM4VQN8 MA Inhibitor DM4VQN8 RN Heterocyclic ketones as inhibitors of histone deacetylase. Bioorg Med Chem Lett. 2003 Nov 17;13(22):3909-13. DM4VQN8 RU https://pubmed.ncbi.nlm.nih.gov/14592473 DM4VQN8 DI DM4VQN8 DM4VQN8 DN 7-(Naphthalen-2-yloxy)-1-oxazol-2-yl-heptan-1-one DM4VQN8 MI TTT6LFV DM4VQN8 MN Histone deacetylase 8 (HDAC8) DM4VQN8 MT DTT DM4VQN8 MA Inhibitor DM4VQN8 RN Heterocyclic ketones as inhibitors of histone deacetylase. Bioorg Med Chem Lett. 2003 Nov 17;13(22):3909-13. DM4VQN8 RU https://pubmed.ncbi.nlm.nih.gov/14592473 DM6I5K1 DI DM6I5K1 DM6I5K1 DN 7-(piperidin-4-ylmethoxy)-2-naphthonitrile DM6I5K1 MI TTPC4TU DM6I5K1 MN 5-HT 3A receptor (HTR3A) DM6I5K1 MT DTT DM6I5K1 MA Inhibitor DM6I5K1 RN Design and optimization of selective serotonin re-uptake inhibitors with high synthetic accessibility. Part 1. Bioorg Med Chem Lett. 2009 Apr 15;19(8):2329-32. DM6I5K1 RU https://pubmed.ncbi.nlm.nih.gov/19282174 DM6I5K1 DI DM6I5K1 DM6I5K1 DN 7-(piperidin-4-ylmethoxy)-2-naphthonitrile DM6I5K1 MI TTVBI8W DM6I5K1 MN Dopamine transporter (DAT) DM6I5K1 MT DTT DM6I5K1 MA Inhibitor DM6I5K1 RN Design and optimization of selective serotonin re-uptake inhibitors with high synthetic accessibility. Part 1. Bioorg Med Chem Lett. 2009 Apr 15;19(8):2329-32. DM6I5K1 RU https://pubmed.ncbi.nlm.nih.gov/19282174 DM6I5K1 DI DM6I5K1 DM6I5K1 DN 7-(piperidin-4-ylmethoxy)-2-naphthonitrile DM6I5K1 MI TTAWNKZ DM6I5K1 MN Norepinephrine transporter (NET) DM6I5K1 MT DTT DM6I5K1 MA Inhibitor DM6I5K1 RN Design and optimization of selective serotonin re-uptake inhibitors with high synthetic accessibility. Part 1. Bioorg Med Chem Lett. 2009 Apr 15;19(8):2329-32. DM6I5K1 RU https://pubmed.ncbi.nlm.nih.gov/19282174 DM6I5K1 DI DM6I5K1 DM6I5K1 DN 7-(piperidin-4-ylmethoxy)-2-naphthonitrile DM6I5K1 MI TT3ROYC DM6I5K1 MN Serotonin transporter (SERT) DM6I5K1 MT DTT DM6I5K1 MA Inhibitor DM6I5K1 RN Design and optimization of selective serotonin re-uptake inhibitors with high synthetic accessibility. Part 1. Bioorg Med Chem Lett. 2009 Apr 15;19(8):2329-32. DM6I5K1 RU https://pubmed.ncbi.nlm.nih.gov/19282174 DM6I5K1 DI DM6I5K1 DM6I5K1 DN 7-(piperidin-4-ylmethoxy)-2-naphthonitrile DM6I5K1 MI TTQ6VDM DM6I5K1 MN Voltage-gated potassium channel Kv11.1 (KCNH2) DM6I5K1 MT DTT DM6I5K1 MA Inhibitor DM6I5K1 RN Design and optimization of selective serotonin re-uptake inhibitors with high synthetic accessibility. Part 1. Bioorg Med Chem Lett. 2009 Apr 15;19(8):2329-32. DM6I5K1 RU https://pubmed.ncbi.nlm.nih.gov/19282174 DM46VT2 DI DM46VT2 DM46VT2 DN 7-(trifluoromethyl)-1H-indole-2,3-dione DM46VT2 MI TTMF541 DM46VT2 MN Liver carboxylesterase (CES1) DM46VT2 MT DTT DM46VT2 MA Inhibitor DM46VT2 RN Selective inhibition of carboxylesterases by isatins, indole-2,3-diones. J Med Chem. 2007 Apr 19;50(8):1876-85. DM46VT2 RU https://pubmed.ncbi.nlm.nih.gov/17378546 DM3FXRC DI DM3FXRC DM3FXRC DN 7,12-Dihydro-5,7,12-triaza-indeno[1,2-a]fluorene DM3FXRC MI TT1MPAY DM3FXRC MN GABA(A) receptor alpha-1 (GABRA1) DM3FXRC MT DTT DM3FXRC MA Inhibitor DM3FXRC RN Synthesis of 7,12-dihydropyrido[3,4-b:5,4-b']diindoles. A novel class of rigid, planar benzodiazepine receptor ligands. J Med Chem. 1987 Mar;30(3):456-8. DM3FXRC RU https://pubmed.ncbi.nlm.nih.gov/3029372 DM3FXRC DI DM3FXRC DM3FXRC DN 7,12-Dihydro-5,7,12-triaza-indeno[1,2-a]fluorene DM3FXRC MI TTNJYV2 DM3FXRC MN Gamma-aminobutyric acid receptor (GAR) DM3FXRC MT DTT DM3FXRC MA Inhibitor DM3FXRC RN Synthesis of 7,12-dihydropyrido[3,4-b:5,4-b']diindoles. A novel class of rigid, planar benzodiazepine receptor ligands. J Med Chem. 1987 Mar;30(3):456-8. DM3FXRC RU https://pubmed.ncbi.nlm.nih.gov/3029372 DMTZ943 DI DMTZ943 DMTZ943 DN 7,12-Dihydro-7,12-diaza-indeno[1,2-a]fluorene DMTZ943 MI TT1MPAY DMTZ943 MN GABA(A) receptor alpha-1 (GABRA1) DMTZ943 MT DTT DMTZ943 MA Inhibitor DMTZ943 RN Synthesis of novel 3-substituted beta-carbolines as benzodiazepine receptor ligands: probing the benzodiazepine receptor pharmacophore. J Med Chem. 1988 Sep;31(9):1854-61. DMTZ943 RU https://pubmed.ncbi.nlm.nih.gov/2842507 DMTZ943 DI DMTZ943 DMTZ943 DN 7,12-Dihydro-7,12-diaza-indeno[1,2-a]fluorene DMTZ943 MI TTNJYV2 DMTZ943 MN Gamma-aminobutyric acid receptor (GAR) DMTZ943 MT DTT DMTZ943 MA Inhibitor DMTZ943 RN Synthesis of novel 3-substituted beta-carbolines as benzodiazepine receptor ligands: probing the benzodiazepine receptor pharmacophore. J Med Chem. 1988 Sep;31(9):1854-61. DMTZ943 RU https://pubmed.ncbi.nlm.nih.gov/2842507 DM5JV8G DI DM5JV8G DM5JV8G DN 7,3',4'-trihydroxyisoflavone DM5JV8G MI TTULVH8 DM5JV8G MN Tyrosinase (TYR) DM5JV8G MT DTT DM5JV8G MA Inhibitor DM5JV8G RN Natural ortho-dihydroxyisoflavone derivatives from aged Korean fermented soybean paste as potent tyrosinase and melanin formation inhibitors. Bioorg Med Chem Lett. 2010 Feb 1;20(3):1162-4. DM5JV8G RU https://pubmed.ncbi.nlm.nih.gov/20022495 DMXQ1K0 DI DMXQ1K0 DMXQ1K0 DN 7,4'-Dihydroxyflavone DMXQ1K0 MI TTSZLWK DMXQ1K0 MN Aromatase (CYP19A1) DMXQ1K0 MT DTT DMXQ1K0 MA Inhibitor DMXQ1K0 RN Pharmacophore modeling strategies for the development of novel nonsteroidal inhibitors of human aromatase (CYP19). Bioorg Med Chem Lett. 2010 May 15;20(10):3050-64. DMXQ1K0 RU https://pubmed.ncbi.nlm.nih.gov/20413308 DMOBEL9 DI DMOBEL9 DMOBEL9 DN 7,8,3',4'-tetrahydroxyflavone DMOBEL9 MI TTQY2EJ DMOBEL9 MN TERT messenger RNA (TERT mRNA) DMOBEL9 MT DTT DMOBEL9 MA Inhibitor DMOBEL9 RN Catecholic flavonoids acting as telomerase inhibitors. J Med Chem. 2004 Dec 16;47(26):6466-75. DMOBEL9 RU https://pubmed.ncbi.nlm.nih.gov/15588081 DM80GFL DI DM80GFL DM80GFL DN 7,8,4'-trihydroxyisoflavone DM80GFL MI DEEZYQV DM80GFL MN Amylosucrase (AMS) DM80GFL MT DME DM80GFL MA Metabolism DM80GFL RN Potential industrial production of a well-soluble, alkaline-stable, and anti-inflammatory isoflavone glucoside from 8-hydroxydaidzein glucosylated by recombinant amylosucrase of Deinococcus geothermalis. Molecules. 2019 Jun 15;24(12). pii: E2236. DM80GFL RU https://pubmed.ncbi.nlm.nih.gov/31208027 DM80GFL DI DM80GFL DM80GFL DN 7,8,4'-trihydroxyisoflavone DM80GFL MI TTULVH8 DM80GFL MN Tyrosinase (TYR) DM80GFL MT DTT DM80GFL MA Inhibitor DM80GFL RN Natural ortho-dihydroxyisoflavone derivatives from aged Korean fermented soybean paste as potent tyrosinase and melanin formation inhibitors. Bioorg Med Chem Lett. 2010 Feb 1;20(3):1162-4. DM80GFL RU https://pubmed.ncbi.nlm.nih.gov/20022495 DMIMLUO DI DMIMLUO DMIMLUO DN 7,8,9,10-tetrahydro-6H-furo-[2,3-g][3]benzazepine DMIMLUO MI TTJQOD7 DMIMLUO MN 5-HT 2A receptor (HTR2A) DMIMLUO MT DTT DMIMLUO MA Inhibitor DMIMLUO RN Synthesis and structure-activity relationships of a series of benzazepine derivatives as 5-HT2C receptor agonists. Bioorg Med Chem. 2008 Mar 15;16(6):3309-20. DMIMLUO RU https://pubmed.ncbi.nlm.nih.gov/18083579 DMIMLUO DI DMIMLUO DMIMLUO DN 7,8,9,10-tetrahydro-6H-furo-[2,3-g][3]benzazepine DMIMLUO MI TT0K1SC DMIMLUO MN 5-HT 2B receptor (HTR2B) DMIMLUO MT DTT DMIMLUO MA Inhibitor DMIMLUO RN Synthesis and structure-activity relationships of a series of benzazepine derivatives as 5-HT2C receptor agonists. Bioorg Med Chem. 2008 Mar 15;16(6):3309-20. DMIMLUO RU https://pubmed.ncbi.nlm.nih.gov/18083579 DMIMLUO DI DMIMLUO DMIMLUO DN 7,8,9,10-tetrahydro-6H-furo-[2,3-g][3]benzazepine DMIMLUO MI TTWJBZ5 DMIMLUO MN 5-HT 2C receptor (HTR2C) DMIMLUO MT DTT DMIMLUO MA Inhibitor DMIMLUO RN Synthesis and structure-activity relationships of a series of benzazepine derivatives as 5-HT2C receptor agonists. Bioorg Med Chem. 2008 Mar 15;16(6):3309-20. DMIMLUO RU https://pubmed.ncbi.nlm.nih.gov/18083579 DMVZA27 DI DMVZA27 DMVZA27 DN 7,8,9,10-tetrahydro-6H-furo-[3,2-g][3]benzazepine DMVZA27 MI TTJQOD7 DMVZA27 MN 5-HT 2A receptor (HTR2A) DMVZA27 MT DTT DMVZA27 MA Inhibitor DMVZA27 RN Synthesis and structure-activity relationships of a series of benzazepine derivatives as 5-HT2C receptor agonists. Bioorg Med Chem. 2008 Mar 15;16(6):3309-20. DMVZA27 RU https://pubmed.ncbi.nlm.nih.gov/18083579 DMVZA27 DI DMVZA27 DMVZA27 DN 7,8,9,10-tetrahydro-6H-furo-[3,2-g][3]benzazepine DMVZA27 MI TT0K1SC DMVZA27 MN 5-HT 2B receptor (HTR2B) DMVZA27 MT DTT DMVZA27 MA Inhibitor DMVZA27 RN Synthesis and structure-activity relationships of a series of benzazepine derivatives as 5-HT2C receptor agonists. Bioorg Med Chem. 2008 Mar 15;16(6):3309-20. DMVZA27 RU https://pubmed.ncbi.nlm.nih.gov/18083579 DMVZA27 DI DMVZA27 DMVZA27 DN 7,8,9,10-tetrahydro-6H-furo-[3,2-g][3]benzazepine DMVZA27 MI TTWJBZ5 DMVZA27 MN 5-HT 2C receptor (HTR2C) DMVZA27 MT DTT DMVZA27 MA Inhibitor DMVZA27 RN Synthesis and structure-activity relationships of a series of benzazepine derivatives as 5-HT2C receptor agonists. Bioorg Med Chem. 2008 Mar 15;16(6):3309-20. DMVZA27 RU https://pubmed.ncbi.nlm.nih.gov/18083579 DMKNQW4 DI DMKNQW4 DMKNQW4 DN 7,8-dichloroquinoline-4-one-3-carboxylic acid DMKNQW4 MI TTER6YH DMKNQW4 MN Casein kinase II alpha (CSNK2A1) DMKNQW4 MT DTT DMKNQW4 MA Inhibitor DMKNQW4 RN Evaluation of 3-carboxy-4(1H)-quinolones as inhibitors of human protein kinase CK2. J Med Chem. 2006 Nov 2;49(22):6443-50. DMKNQW4 RU https://pubmed.ncbi.nlm.nih.gov/17064064 DMQU4XM DI DMQU4XM DMQU4XM DN 7,8-dihydrobiopterin DMQU4XM MI TTG9CFY DMQU4XM MN Bacterial Dihydroneopterinaldolase (Bact folB) DMQU4XM MT DTT DMQU4XM MA Inhibitor DMQU4XM RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMQU4XM RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMQU4XM DI DMQU4XM DMQU4XM DN 7,8-dihydrobiopterin DMQU4XM MI TTF10I9 DMQU4XM MN Nitric-oxide synthase inducible (NOS2) DMQU4XM MT DTT DMQU4XM MA Inhibitor DMQU4XM RN DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Nucleic Acids Res. 2011 Jan;39(Database issue):D1035-41. DMQU4XM RU https://pubmed.ncbi.nlm.nih.gov/21059682 DMQU4XM DI DMQU4XM DMQU4XM DN 7,8-dihydrobiopterin DMQU4XM MI TTUHP71 DMQU4XM MN Tyrosine 3-monooxygenase (TH) DMQU4XM MT DTT DMQU4XM MA Inhibitor DMQU4XM RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMQU4XM RU https://pubmed.ncbi.nlm.nih.gov/17139284 DM5TXY1 DI DM5TXY1 DM5TXY1 DN 7,8-Dihydroneopterin DM5TXY1 MI TTG9CFY DM5TXY1 MN Bacterial Dihydroneopterinaldolase (Bact folB) DM5TXY1 MT DTT DM5TXY1 MA Inhibitor DM5TXY1 RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DM5TXY1 RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMUB5E8 DI DMUB5E8 DMUB5E8 DN 7,8-dihydroxy-4-phenyl-2H-chromen-2-one DMUB5E8 MI TTKWFB8 DMUB5E8 MN Catechol-O-methyl-transferase (COMT) DMUB5E8 MT DTT DMUB5E8 MA Inhibitor DMUB5E8 RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DMUB5E8 RU https://pubmed.ncbi.nlm.nih.gov/10592235 DMPF6MD DI DMPF6MD DMPF6MD DN 7,8-Dimethoxy-1,4-dimethylquinolin-2(1H)-one DMPF6MD MI TTJLP0R DMPF6MD MN Quinone reductase 2 (NQO2) DMPF6MD MT DTT DMPF6MD MA Inhibitor DMPF6MD RN Synthesis of casimiroin and optimization of its quinone reductase 2 and aromatase inhibitory activities. J Med Chem. 2009 Apr 9;52(7):1873-84. DMPF6MD RU https://pubmed.ncbi.nlm.nih.gov/19265439 DMO8GEI DI DMO8GEI DMO8GEI DN 7,9-octadecadiynoic acid DMO8GEI MI TTPADOQ DMO8GEI MN HMG-CoA reductase (HMGCR) DMO8GEI MT DTT DMO8GEI MA Inhibitor DMO8GEI RN Novel Acetylenic Acids from the Root Bark of Paramacrolobium caeruleum: Inhibitors of 3-Hydroxy-3-methyl-glutaryl Coenzyme A Reductase J. Nat. Prod. 52(1):153-161 (1989). DMO8GEI RU http://pubs.acs.org/doi/abs/10.1021/np50061a020 DMPEXTB DI DMPEXTB DMPEXTB DN 7,9-tetradecadiynoic acid DMPEXTB MI TTPADOQ DMPEXTB MN HMG-CoA reductase (HMGCR) DMPEXTB MT DTT DMPEXTB MA Inhibitor DMPEXTB RN Novel Acetylenic Acids from the Root Bark of Paramacrolobium caeruleum: Inhibitors of 3-Hydroxy-3-methyl-glutaryl Coenzyme A Reductase J. Nat. Prod. 52(1):153-161 (1989). DMPEXTB RU http://pubs.acs.org/doi/abs/10.1021/np50061a020 DMNGLM1 DI DMNGLM1 DMNGLM1 DN 7-[1,2,4]Triazol-4-ylmethyl-chromen-4-one DMNGLM1 MI TTSZLWK DMNGLM1 MN Aromatase (CYP19A1) DMNGLM1 MT DTT DMNGLM1 MA Inhibitor DMNGLM1 RN A new class of nonsteroidal aromatase inhibitors: design and synthesis of chromone and xanthone derivatives and inhibition of the P450 enzymes aromatase and 17 alpha-hydroxylase/C17,20-lyase. J Med Chem. 2001 Mar 1;44(5):672-80. DMNGLM1 RU https://pubmed.ncbi.nlm.nih.gov/11262078 DMQCDT1 DI DMQCDT1 DMQCDT1 DN 7-Acetonyloxy-3,4-cyclohexene-8-methylcoumarin DMQCDT1 MI TT3WG5C DMQCDT1 MN Monoamine oxidase type A (MAO-A) DMQCDT1 MT DTT DMQCDT1 MA Inhibitor DMQCDT1 RN Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors. J Med Chem. 2008 Nov 13;51(21):6740-51. DMQCDT1 RU https://pubmed.ncbi.nlm.nih.gov/18834112 DMQCDT1 DI DMQCDT1 DMQCDT1 DN 7-Acetonyloxy-3,4-cyclohexene-8-methylcoumarin DMQCDT1 MI TTGP7BY DMQCDT1 MN Monoamine oxidase type B (MAO-B) DMQCDT1 MT DTT DMQCDT1 MA Inhibitor DMQCDT1 RN Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors. J Med Chem. 2008 Nov 13;51(21):6740-51. DMQCDT1 RU https://pubmed.ncbi.nlm.nih.gov/18834112 DMQMTSX DI DMQMTSX DMQMTSX DN 7-Acetonyloxy-3,4-cyclopentene-8-methylcoumarin DMQMTSX MI TT3WG5C DMQMTSX MN Monoamine oxidase type A (MAO-A) DMQMTSX MT DTT DMQMTSX MA Inhibitor DMQMTSX RN Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors. J Med Chem. 2008 Nov 13;51(21):6740-51. DMQMTSX RU https://pubmed.ncbi.nlm.nih.gov/18834112 DMQMTSX DI DMQMTSX DMQMTSX DN 7-Acetonyloxy-3,4-cyclopentene-8-methylcoumarin DMQMTSX MI TTGP7BY DMQMTSX MN Monoamine oxidase type B (MAO-B) DMQMTSX MT DTT DMQMTSX MA Inhibitor DMQMTSX RN Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors. J Med Chem. 2008 Nov 13;51(21):6740-51. DMQMTSX RU https://pubmed.ncbi.nlm.nih.gov/18834112 DMYSNQO DI DMYSNQO DMYSNQO DN 7-acetonyloxy-3-acetylamino-8-methoxycoumarin DMYSNQO MI TT3WG5C DMYSNQO MN Monoamine oxidase type A (MAO-A) DMYSNQO MT DTT DMYSNQO MA Inhibitor DMYSNQO RN A QSAR model for in silico screening of MAO-A inhibitors. Prediction, synthesis, and biological assay of novel coumarins. J Med Chem. 2006 Feb 9;49(3):1149-56. DMYSNQO RU https://pubmed.ncbi.nlm.nih.gov/16451079 DMPRBO1 DI DMPRBO1 DMPRBO1 DN 7-Allyl-1,3-dimethyl-3,7-dihydro-purine-2,6-dione DMPRBO1 MI TTM2AOE DMPRBO1 MN Adenosine A2a receptor (ADORA2A) DMPRBO1 MT DTT DMPRBO1 MA Inhibitor DMPRBO1 RN Analogues of caffeine and theophylline: effect of structural alterations on affinity at adenosine receptors. J Med Chem. 1986 Jul;29(7):1305-8. DMPRBO1 RU https://pubmed.ncbi.nlm.nih.gov/3806581 DMHJ6TU DI DMHJ6TU DMHJ6TU DN 7-Allyl-1,3-dipropyl-3,7-dihydro-purine-2,6-dione DMHJ6TU MI TTM2AOE DMHJ6TU MN Adenosine A2a receptor (ADORA2A) DMHJ6TU MT DTT DMHJ6TU MA Inhibitor DMHJ6TU RN Analogues of caffeine and theophylline: effect of structural alterations on affinity at adenosine receptors. J Med Chem. 1986 Jul;29(7):1305-8. DMHJ6TU RU https://pubmed.ncbi.nlm.nih.gov/3806581 DMSRQ1L DI DMSRQ1L DMSRQ1L DN 7-Allyl-2-(4-hydroxy-phenyl)-benzooxazol-5-ol DMSRQ1L MI TTZAYWL DMSRQ1L MN Estrogen receptor (ESR) DMSRQ1L MT DTT DMSRQ1L MA Inhibitor DMSRQ1L RN Design and synthesis of aryl diphenolic azoles as potent and selective estrogen receptor-beta ligands. J Med Chem. 2004 Oct 7;47(21):5021-40. DMSRQ1L RU https://pubmed.ncbi.nlm.nih.gov/15456246 DMSRQ1L DI DMSRQ1L DMSRQ1L DN 7-Allyl-2-(4-hydroxy-phenyl)-benzooxazol-5-ol DMSRQ1L MI TTOM3J0 DMSRQ1L MN Estrogen receptor beta (ESR2) DMSRQ1L MT DTT DMSRQ1L MA Inhibitor DMSRQ1L RN Design and synthesis of aryl diphenolic azoles as potent and selective estrogen receptor-beta ligands. J Med Chem. 2004 Oct 7;47(21):5021-40. DMSRQ1L RU https://pubmed.ncbi.nlm.nih.gov/15456246 DM2N8TW DI DM2N8TW DM2N8TW DN 7alpha,25-dihydroxycholesterol DM2N8TW MI TTME5YJ DM2N8TW MN EBV-induced G-protein coupled receptor 2 (GPR183) DM2N8TW MT DTT DM2N8TW MA Agonist DM2N8TW RN Oxysterols direct immune cell migration via EBI2. Nature. 2011 Jul 27;475(7357):524-7. DM2N8TW RU https://pubmed.ncbi.nlm.nih.gov/21796212 DM52UOM DI DM52UOM DM52UOM DN 7alpha,27-dihydroxycholesterol DM52UOM MI TTME5YJ DM52UOM MN EBV-induced G-protein coupled receptor 2 (GPR183) DM52UOM MT DTT DM52UOM MA Agonist DM52UOM RN Oxysterols direct B-cell migration through EBI2. Nature. 2011 Jul 27;475(7357):519-23. DM52UOM RU https://pubmed.ncbi.nlm.nih.gov/21796211 DMD6UC9 DI DMD6UC9 DMD6UC9 DN 7alpha-Cl-ginkgolide B DMD6UC9 MI TTQL5VC DMD6UC9 MN Platelet-activating factor receptor (PTAFR) DMD6UC9 MT DTT DMD6UC9 MA Antagonist DMD6UC9 RN Preparation of 7-substituted ginkgolide derivatives: potent platelet activating factor (PAF) receptor antagonists. J Med Chem. 2003 Feb 13;46(4):601-8. DMD6UC9 RU https://pubmed.ncbi.nlm.nih.gov/12570381 DMRQ24A DI DMRQ24A DMRQ24A DN 7alpha-F-ginkgolide B DMRQ24A MI TTQL5VC DMRQ24A MN Platelet-activating factor receptor (PTAFR) DMRQ24A MT DTT DMRQ24A MA Antagonist DMRQ24A RN Preparation of 7-substituted ginkgolide derivatives: potent platelet activating factor (PAF) receptor antagonists. J Med Chem. 2003 Feb 13;46(4):601-8. DMRQ24A RU https://pubmed.ncbi.nlm.nih.gov/12570381 DMH6LD0 DI DMH6LD0 DMH6LD0 DN 7alpha-hydroxycholesterol DMH6LD0 MI TTME5YJ DMH6LD0 MN EBV-induced G-protein coupled receptor 2 (GPR183) DMH6LD0 MT DTT DMH6LD0 MA Agonist DMH6LD0 RN Oxysterols direct B-cell migration through EBI2. Nature. 2011 Jul 27;475(7357):519-23. DMH6LD0 RU https://pubmed.ncbi.nlm.nih.gov/21796211 DMGNWBV DI DMGNWBV DMGNWBV DN 7alpha-N3-ginkgolide B DMGNWBV MI TTQL5VC DMGNWBV MN Platelet-activating factor receptor (PTAFR) DMGNWBV MT DTT DMGNWBV MA Antagonist DMGNWBV RN Preparation of 7-substituted ginkgolide derivatives: potent platelet activating factor (PAF) receptor antagonists. J Med Chem. 2003 Feb 13;46(4):601-8. DMGNWBV RU https://pubmed.ncbi.nlm.nih.gov/12570381 DMZUYX1 DI DMZUYX1 DMZUYX1 DN 7alpha-NH2-ginkgolide B DMZUYX1 MI TTQL5VC DMZUYX1 MN Platelet-activating factor receptor (PTAFR) DMZUYX1 MT DTT DMZUYX1 MA Antagonist DMZUYX1 RN Preparation of 7-substituted ginkgolide derivatives: potent platelet activating factor (PAF) receptor antagonists. J Med Chem. 2003 Feb 13;46(4):601-8. DMZUYX1 RU https://pubmed.ncbi.nlm.nih.gov/12570381 DMWAB7F DI DMWAB7F DMWAB7F DN 7alpha-NHEt-ginkgolide B DMWAB7F MI TTQL5VC DMWAB7F MN Platelet-activating factor receptor (PTAFR) DMWAB7F MT DTT DMWAB7F MA Antagonist DMWAB7F RN Preparation of 7-substituted ginkgolide derivatives: potent platelet activating factor (PAF) receptor antagonists. J Med Chem. 2003 Feb 13;46(4):601-8. DMWAB7F RU https://pubmed.ncbi.nlm.nih.gov/12570381 DMSPLYF DI DMSPLYF DMSPLYF DN 7alpha-NHMe-ginkgolide B DMSPLYF MI TTQL5VC DMSPLYF MN Platelet-activating factor receptor (PTAFR) DMSPLYF MT DTT DMSPLYF MA Antagonist DMSPLYF RN Preparation of 7-substituted ginkgolide derivatives: potent platelet activating factor (PAF) receptor antagonists. J Med Chem. 2003 Feb 13;46(4):601-8. DMSPLYF RU https://pubmed.ncbi.nlm.nih.gov/12570381 DMN1U56 DI DMN1U56 DMN1U56 DN 7alpha-OAc-ginkgolide B DMN1U56 MI TTQL5VC DMN1U56 MN Platelet-activating factor receptor (PTAFR) DMN1U56 MT DTT DMN1U56 MA Antagonist DMN1U56 RN Preparation of 7-substituted ginkgolide derivatives: potent platelet activating factor (PAF) receptor antagonists. J Med Chem. 2003 Feb 13;46(4):601-8. DMN1U56 RU https://pubmed.ncbi.nlm.nih.gov/12570381 DMGAPCD DI DMGAPCD DMGAPCD DN 7alpha-OCOCH2Ph-ginkgolide B DMGAPCD MI TTQL5VC DMGAPCD MN Platelet-activating factor receptor (PTAFR) DMGAPCD MT DTT DMGAPCD MA Antagonist DMGAPCD RN Preparation of 7-substituted ginkgolide derivatives: potent platelet activating factor (PAF) receptor antagonists. J Med Chem. 2003 Feb 13;46(4):601-8. DMGAPCD RU https://pubmed.ncbi.nlm.nih.gov/12570381 DMDUB63 DI DMDUB63 DMDUB63 DN 7-amino-4-hydroxy-2-naphthalenesulfonic acid DMDUB63 MI TTGTQHC DMDUB63 MN DNA topoisomerase I (TOP1) DMDUB63 MT DTT DMDUB63 MA Binder DMDUB63 RN Comparison of responses of DNA topoisomerase I from Candida albicans and human cells to four new agents which stimulate topoisomerase-dependent DNA nicking. FEMS Microbiol Lett. 1996 May 1;138(2-3):105-11. DMDUB63 RU https://pubmed.ncbi.nlm.nih.gov/9026436 DMC8O3Z DI DMC8O3Z DMC8O3Z DN 7-AMINO-4-METHYL-CHROMEN-2-ONE DMC8O3Z MI TTL2ADK DMC8O3Z MN Rotamase A (PPIA) DMC8O3Z MT DTT DMC8O3Z MA Inhibitor DMC8O3Z RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DMC8O3Z RU https://pubmed.ncbi.nlm.nih.gov/10592235 DMZDP5S DI DMZDP5S DMZDP5S DN 7-benzoyloxy-2-(morpholin-4-yl)-chromen-4-one DMZDP5S MI TTK3PY9 DMZDP5S MN DNA-dependent protein kinase catalytic (PRKDC) DMZDP5S MT DTT DMZDP5S MA Inhibitor DMZDP5S RN Discovery of potent chromen-4-one inhibitors of the DNA-dependent protein kinase (DNA-PK) using a small-molecule library approach. J Med Chem. 2005 Dec 1;48(24):7829-46. DMZDP5S RU https://pubmed.ncbi.nlm.nih.gov/16302822 DMCJED6 DI DMCJED6 DMCJED6 DN 7-benzylidenenaltrexone DMCJED6 MI TT27RFC DMCJED6 MN Opioid receptor delta (OPRD1) DMCJED6 MT DTT DMCJED6 MA Antagonist DMCJED6 RN Delta-opioid receptor antagonists as a new concept for central acting antitussive drugs. Pulm Pharmacol Ther. 2002;15(3):235-40. DMCJED6 RU https://pubmed.ncbi.nlm.nih.gov/12099770 DMMXAEN DI DMMXAEN DMMXAEN DN 7-benzyloxy-2-(morpholin-4-yl)-chromen-4-one DMMXAEN MI TTK3PY9 DMMXAEN MN DNA-dependent protein kinase catalytic (PRKDC) DMMXAEN MT DTT DMMXAEN MA Inhibitor DMMXAEN RN Discovery of potent chromen-4-one inhibitors of the DNA-dependent protein kinase (DNA-PK) using a small-molecule library approach. J Med Chem. 2005 Dec 1;48(24):7829-46. DMMXAEN RU https://pubmed.ncbi.nlm.nih.gov/16302822 DMYKXWE DI DMYKXWE DMYKXWE DN 7beta, 25-dihydroxycholesterol DMYKXWE MI TTME5YJ DMYKXWE MN EBV-induced G-protein coupled receptor 2 (GPR183) DMYKXWE MT DTT DMYKXWE MA Agonist DMYKXWE RN Oxysterols direct B-cell migration through EBI2. Nature. 2011 Jul 27;475(7357):519-23. DMYKXWE RU https://pubmed.ncbi.nlm.nih.gov/21796211 DMSDINR DI DMSDINR DMSDINR DN 7beta, 27-dihydroxycholesterol DMSDINR MI TTME5YJ DMSDINR MN EBV-induced G-protein coupled receptor 2 (GPR183) DMSDINR MT DTT DMSDINR MA Agonist DMSDINR RN Oxysterols direct B-cell migration through EBI2. Nature. 2011 Jul 27;475(7357):519-23. DMSDINR RU https://pubmed.ncbi.nlm.nih.gov/21796211 DMPHJZU DI DMPHJZU DMPHJZU DN 7beta-hydroxycholesterol DMPHJZU MI TTME5YJ DMPHJZU MN EBV-induced G-protein coupled receptor 2 (GPR183) DMPHJZU MT DTT DMPHJZU MA Agonist DMPHJZU RN Oxysterols direct B-cell migration through EBI2. Nature. 2011 Jul 27;475(7357):519-23. DMPHJZU RU https://pubmed.ncbi.nlm.nih.gov/21796211 DMV54MT DI DMV54MT DMV54MT DN 7-Biphenyl-4-yl-heptanoic acid hydroxyamide DMV54MT MI TT6R7JZ DMV54MT MN Histone deacetylase 1 (HDAC1) DMV54MT MT DTT DMV54MT MA Inhibitor DMV54MT RN A novel series of histone deacetylase inhibitors incorporating hetero aromatic ring systems as connection units. Bioorg Med Chem Lett. 2003 Nov 3;13(21):3817-20. DMV54MT RU https://pubmed.ncbi.nlm.nih.gov/14552787 DMV54MT DI DMV54MT DMV54MT DN 7-Biphenyl-4-yl-heptanoic acid hydroxyamide DMV54MT MI TTSHTOI DMV54MT MN Histone deacetylase 2 (HDAC2) DMV54MT MT DTT DMV54MT MA Inhibitor DMV54MT RN A novel series of histone deacetylase inhibitors incorporating hetero aromatic ring systems as connection units. Bioorg Med Chem Lett. 2003 Nov 3;13(21):3817-20. DMV54MT RU https://pubmed.ncbi.nlm.nih.gov/14552787 DMYBNCO DI DMYBNCO DMYBNCO DN 7-bromo-1H-indazole DMYBNCO MI TTZUFI5 DMYBNCO MN Nitric-oxide synthase brain (NOS1) DMYBNCO MT DTT DMYBNCO MA Inhibitor DMYBNCO RN 4-substituted indazoles as new inhibitors of neuronal nitric oxide synthase. Bioorg Med Chem Lett. 2007 Jun 1;17(11):3177-80. DMYBNCO RU https://pubmed.ncbi.nlm.nih.gov/17395463 DMA8DXG DI DMA8DXG DMA8DXG DN 7-Bromo-2-(4-hydroxy-phenyl)-benzofuran-5-ol DMA8DXG MI TTZAYWL DMA8DXG MN Estrogen receptor (ESR) DMA8DXG MT DTT DMA8DXG MA Inhibitor DMA8DXG RN 7-Substituted 2-phenyl-benzofurans as ER beta selective ligands. Bioorg Med Chem Lett. 2004 Oct 4;14(19):4925-9. DMA8DXG RU https://pubmed.ncbi.nlm.nih.gov/15341953 DMA8DXG DI DMA8DXG DMA8DXG DN 7-Bromo-2-(4-hydroxy-phenyl)-benzofuran-5-ol DMA8DXG MI TTOM3J0 DMA8DXG MN Estrogen receptor beta (ESR2) DMA8DXG MT DTT DMA8DXG MA Inhibitor DMA8DXG RN 7-Substituted 2-phenyl-benzofurans as ER beta selective ligands. Bioorg Med Chem Lett. 2004 Oct 4;14(19):4925-9. DMA8DXG RU https://pubmed.ncbi.nlm.nih.gov/15341953 DMVTH0Q DI DMVTH0Q DMVTH0Q DN 7-Bromo-2,3,4,9-tetrahydro-1H-beta-carboline DMVTH0Q MI TT3WG5C DMVTH0Q MN Monoamine oxidase type A (MAO-A) DMVTH0Q MT DTT DMVTH0Q MA Inhibitor DMVTH0Q RN Binding of beta-carbolines at imidazoline I2 receptors: a structure-affinity investigation. Bioorg Med Chem Lett. 2004 Feb 23;14(4):999-1002. DMVTH0Q RU https://pubmed.ncbi.nlm.nih.gov/15013009 DMVTH0Q DI DMVTH0Q DMVTH0Q DN 7-Bromo-2,3,4,9-tetrahydro-1H-beta-carboline DMVTH0Q MI TTGP7BY DMVTH0Q MN Monoamine oxidase type B (MAO-B) DMVTH0Q MT DTT DMVTH0Q MA Inhibitor DMVTH0Q RN Binding of beta-carbolines at imidazoline I2 receptors: a structure-affinity investigation. Bioorg Med Chem Lett. 2004 Feb 23;14(4):999-1002. DMVTH0Q RU https://pubmed.ncbi.nlm.nih.gov/15013009 DMG8ZJA DI DMG8ZJA DMG8ZJA DN 7-Bromo-2-phenyl-[1,8]naphthyridin-4-ol DMG8ZJA MI TTK25J1 DMG8ZJA MN Adenosine A1 receptor (ADORA1) DMG8ZJA MT DTT DMG8ZJA MA Inhibitor DMG8ZJA RN Study on affinity profile toward native human and bovine adenosine receptors of a series of 1,8-naphthyridine derivatives. J Med Chem. 2004 Jun 3;47(12):3019-31. DMG8ZJA RU https://pubmed.ncbi.nlm.nih.gov/15163184 DMCWYT7 DI DMCWYT7 DMCWYT7 DN 7-Bromo-4,9-dihydro-3H-beta-carboline DMCWYT7 MI TT3WG5C DMCWYT7 MN Monoamine oxidase type A (MAO-A) DMCWYT7 MT DTT DMCWYT7 MA Inhibitor DMCWYT7 RN Binding of beta-carbolines at imidazoline I2 receptors: a structure-affinity investigation. Bioorg Med Chem Lett. 2004 Feb 23;14(4):999-1002. DMCWYT7 RU https://pubmed.ncbi.nlm.nih.gov/15013009 DMCWYT7 DI DMCWYT7 DMCWYT7 DN 7-Bromo-4,9-dihydro-3H-beta-carboline DMCWYT7 MI TTGP7BY DMCWYT7 MN Monoamine oxidase type B (MAO-B) DMCWYT7 MT DTT DMCWYT7 MA Inhibitor DMCWYT7 RN Binding of beta-carbolines at imidazoline I2 receptors: a structure-affinity investigation. Bioorg Med Chem Lett. 2004 Feb 23;14(4):999-1002. DMCWYT7 RU https://pubmed.ncbi.nlm.nih.gov/15013009 DMX85IF DI DMX85IF DMX85IF DN 7-bromo-6H-chromeno[4,3-b]quinoline-3,9-diol DMX85IF MI TTPNQAC DMX85IF MN Estrogen-related receptor-alpha (ESRRA) DMX85IF MT DTT DMX85IF MA Inhibitor DMX85IF RN ERbeta ligands. Part 6: 6H-Chromeno[4,3-b]quinolines as a new series of estrogen receptor beta-selective ligands. Bioorg Med Chem Lett. 2007 Jul 15;17(14):4053-6. DMX85IF RU https://pubmed.ncbi.nlm.nih.gov/17482813 DM3G8I7 DI DM3G8I7 DM3G8I7 DN 7-bromoindirubin-3-acetoxime DM3G8I7 MI TTLYXIT DM3G8I7 MN Aurora kinase C (AURKC) DM3G8I7 MT DTT DM3G8I7 MA Inhibitor DM3G8I7 RN An integrated computational approach to the phenomenon of potent and selective inhibition of aurora kinases B and C by a series of 7-substituted in... J Med Chem. 2007 Aug 23;50(17):4027-37. DM3G8I7 RU https://pubmed.ncbi.nlm.nih.gov/17665890 DM07QD3 DI DM07QD3 DM07QD3 DN 7-bromoindirubin-3-oxime DM07QD3 MI TT9RTBL DM07QD3 MN Aurora B messenger RNA (AURKB mRNA) DM07QD3 MT DTT DM07QD3 MA Inhibitor DM07QD3 RN An integrated computational approach to the phenomenon of potent and selective inhibition of aurora kinases B and C by a series of 7-substituted in... J Med Chem. 2007 Aug 23;50(17):4027-37. DM07QD3 RU https://pubmed.ncbi.nlm.nih.gov/17665890 DM07QD3 DI DM07QD3 DM07QD3 DN 7-bromoindirubin-3-oxime DM07QD3 MI TTLYXIT DM07QD3 MN Aurora kinase C (AURKC) DM07QD3 MT DTT DM07QD3 MA Inhibitor DM07QD3 RN An integrated computational approach to the phenomenon of potent and selective inhibition of aurora kinases B and C by a series of 7-substituted in... J Med Chem. 2007 Aug 23;50(17):4027-37. DM07QD3 RU https://pubmed.ncbi.nlm.nih.gov/17665890 DML8PH7 DI DML8PH7 DML8PH7 DN 7-bromo-N-(3-bromophenyl)isoquinolin-1-amine DML8PH7 MI TTHS256 DML8PH7 MN Metabotropic glutamate receptor 5 (mGluR5) DML8PH7 MT DTT DML8PH7 MA Inhibitor DML8PH7 RN Discovery and SAR of 6-substituted-4-anilinoquinazolines as non-competitive antagonists of mGlu5. Bioorg Med Chem Lett. 2009 Dec 1;19(23):6623-6. DML8PH7 RU https://pubmed.ncbi.nlm.nih.gov/19854049 DM78C5A DI DM78C5A DM78C5A DN 7-butoxy-2H-chromen-2-one DM78C5A MI TTUNARX DM78C5A MN Carbonic anhydrase (CA) DM78C5A MT DTT DM78C5A MA Inhibitor DM78C5A RN Deciphering the mechanism of carbonic anhydrase inhibition with coumarins and thiocoumarins. J Med Chem. 2010 Jan 14;53(1):335-44. DM78C5A RU https://pubmed.ncbi.nlm.nih.gov/19911821 DM78C5A DI DM78C5A DM78C5A DN 7-butoxy-2H-chromen-2-one DM78C5A MI TT2LVK8 DM78C5A MN Carbonic anhydrase IX (CA-IX) DM78C5A MT DTT DM78C5A MA Inhibitor DM78C5A RN Deciphering the mechanism of carbonic anhydrase inhibition with coumarins and thiocoumarins. J Med Chem. 2010 Jan 14;53(1):335-44. DM78C5A RU https://pubmed.ncbi.nlm.nih.gov/19911821 DM78C5A DI DM78C5A DM78C5A DN 7-butoxy-2H-chromen-2-one DM78C5A MI TTCFSPE DM78C5A MN Carbonic anhydrase VI (CA-VI) DM78C5A MT DTT DM78C5A MA Inhibitor DM78C5A RN Deciphering the mechanism of carbonic anhydrase inhibition with coumarins and thiocoumarins. J Med Chem. 2010 Jan 14;53(1):335-44. DM78C5A RU https://pubmed.ncbi.nlm.nih.gov/19911821 DM78C5A DI DM78C5A DM78C5A DN 7-butoxy-2H-chromen-2-one DM78C5A MI TTSYM0R DM78C5A MN Carbonic anhydrase XII (CA-XII) DM78C5A MT DTT DM78C5A MA Inhibitor DM78C5A RN Deciphering the mechanism of carbonic anhydrase inhibition with coumarins and thiocoumarins. J Med Chem. 2010 Jan 14;53(1):335-44. DM78C5A RU https://pubmed.ncbi.nlm.nih.gov/19911821 DM78C5A DI DM78C5A DM78C5A DN 7-butoxy-2H-chromen-2-one DM78C5A MI TTEYTKG DM78C5A MN Carbonic anhydrase XIV (CA-XIV) DM78C5A MT DTT DM78C5A MA Inhibitor DM78C5A RN Deciphering the mechanism of carbonic anhydrase inhibition with coumarins and thiocoumarins. J Med Chem. 2010 Jan 14;53(1):335-44. DM78C5A RU https://pubmed.ncbi.nlm.nih.gov/19911821 DMQ8BIX DI DMQ8BIX DMQ8BIX DN 7-Butyl-2-(4-hydroxy-phenyl)-benzooxazol-5-ol DMQ8BIX MI TTZAYWL DMQ8BIX MN Estrogen receptor (ESR) DMQ8BIX MT DTT DMQ8BIX MA Inhibitor DMQ8BIX RN Design and synthesis of aryl diphenolic azoles as potent and selective estrogen receptor-beta ligands. J Med Chem. 2004 Oct 7;47(21):5021-40. DMQ8BIX RU https://pubmed.ncbi.nlm.nih.gov/15456246 DMQ8BIX DI DMQ8BIX DMQ8BIX DN 7-Butyl-2-(4-hydroxy-phenyl)-benzooxazol-5-ol DMQ8BIX MI TTOM3J0 DMQ8BIX MN Estrogen receptor beta (ESR2) DMQ8BIX MT DTT DMQ8BIX MA Inhibitor DMQ8BIX RN Design and synthesis of aryl diphenolic azoles as potent and selective estrogen receptor-beta ligands. J Med Chem. 2004 Oct 7;47(21):5021-40. DMQ8BIX RU https://pubmed.ncbi.nlm.nih.gov/15456246 DMVTK0A DI DMVTK0A DMVTK0A DN 7-Butyl-azepan-(2Z)-ylideneamine DMVTK0A MI TTZUFI5 DMVTK0A MN Nitric-oxide synthase brain (NOS1) DMVTK0A MT DTT DMVTK0A MA Inhibitor DMVTK0A RN Selective heterocyclic amidine inhibitors of human inducible nitric oxide synthase. Bioorg Med Chem Lett. 2001 Oct 8;11(19):2651-3. DMVTK0A RU https://pubmed.ncbi.nlm.nih.gov/11551770 DMVTK0A DI DMVTK0A DMVTK0A DN 7-Butyl-azepan-(2Z)-ylideneamine DMVTK0A MI TTF10I9 DMVTK0A MN Nitric-oxide synthase inducible (NOS2) DMVTK0A MT DTT DMVTK0A MA Inhibitor DMVTK0A RN Selective heterocyclic amidine inhibitors of human inducible nitric oxide synthase. Bioorg Med Chem Lett. 2001 Oct 8;11(19):2651-3. DMVTK0A RU https://pubmed.ncbi.nlm.nih.gov/11551770 DM1SEXA DI DM1SEXA DM1SEXA DN 7-Chloro-1,2,3,4-tetrahydro-acridin-9-ylamine DM1SEXA MI TT1RS9F DM1SEXA MN Acetylcholinesterase (AChE) DM1SEXA MT DTT DM1SEXA MA Inhibitor DM1SEXA RN The synthesis and in vitro acetylcholinesterase and butyrylcholinesterase inhibitory activity of tacrine (Cognex ) derivaties, Bioorg. Med. Chem. Lett. 2(8):861-864 (1992). DM1SEXA RU http://www.sciencedirect.com/science/article/pii/S0960894X00805454 DMP5JF8 DI DMP5JF8 DMP5JF8 DN 7-Chloro-1,2,3,4-tetrahydro-pyrazino[1,2-a]indole DMP5JF8 MI TTJQOD7 DMP5JF8 MN 5-HT 2A receptor (HTR2A) DMP5JF8 MT DTT DMP5JF8 MA Inhibitor DMP5JF8 RN Evaluation of isotryptamine derivatives at 5-HT(2) serotonin receptors. Bioorg Med Chem Lett. 2002 Jan 21;12(2):155-8. DMP5JF8 RU https://pubmed.ncbi.nlm.nih.gov/11755343 DMWUS5Q DI DMWUS5Q DMWUS5Q DN 7-Chloro-1,3-dihydro-imidazo[4,5-b]quinolin-2-one DMWUS5Q MI TT06AWU DMWUS5Q MN Phosphodiesterase 3A (PDE3A) DMWUS5Q MT DTT DMWUS5Q MA Inhibitor DMWUS5Q RN 1,3-Dihydro-2H-imidazo[4,5-b]quinolin-2-ones--inhibitors of blood platelet cAMP phosphodiesterase and induced aggregation. J Med Chem. 1991 Sep;34(9):2906-16. DMWUS5Q RU https://pubmed.ncbi.nlm.nih.gov/1654430 DMPJWIB DI DMPJWIB DMPJWIB DN 7-chloro-1,3-dihydroxyacridone DMPJWIB MI TT0IHXV DMPJWIB MN DNA topoisomerase II (TOP2) DMPJWIB MT DTT DMPJWIB MA Inhibitor DMPJWIB RN 1,3-Dihydroxyacridone derivatives as inhibitors of herpes virus replication. Antiviral Res. 2000 Feb;45(2):123-34. DMPJWIB RU https://pubmed.ncbi.nlm.nih.gov/10809021 DMX8DZM DI DMX8DZM DMX8DZM DN 7-chloro-1H-indazole DMX8DZM MI TTZUFI5 DMX8DZM MN Nitric-oxide synthase brain (NOS1) DMX8DZM MT DTT DMX8DZM MA Inhibitor DMX8DZM RN 4-substituted indazoles as new inhibitors of neuronal nitric oxide synthase. Bioorg Med Chem Lett. 2007 Jun 1;17(11):3177-80. DMX8DZM RU https://pubmed.ncbi.nlm.nih.gov/17395463 DMCZLKA DI DMCZLKA DMCZLKA DN 7-chloro-1H-indole-2,3-dione DMCZLKA MI TTMF541 DMCZLKA MN Liver carboxylesterase (CES1) DMCZLKA MT DTT DMCZLKA MA Inhibitor DMCZLKA RN Selective inhibition of carboxylesterases by isatins, indole-2,3-diones. J Med Chem. 2007 Apr 19;50(8):1876-85. DMCZLKA RU https://pubmed.ncbi.nlm.nih.gov/17378546 DM38HKE DI DM38HKE DM38HKE DN 7-Chloro-2-(4-hydroxy-phenyl)-benzofuran-5-ol DM38HKE MI TTZAYWL DM38HKE MN Estrogen receptor (ESR) DM38HKE MT DTT DM38HKE MA Inhibitor DM38HKE RN 7-Substituted 2-phenyl-benzofurans as ER beta selective ligands. Bioorg Med Chem Lett. 2004 Oct 4;14(19):4925-9. DM38HKE RU https://pubmed.ncbi.nlm.nih.gov/15341953 DM38HKE DI DM38HKE DM38HKE DN 7-Chloro-2-(4-hydroxy-phenyl)-benzofuran-5-ol DM38HKE MI TTOM3J0 DM38HKE MN Estrogen receptor beta (ESR2) DM38HKE MT DTT DM38HKE MA Inhibitor DM38HKE RN 7-Substituted 2-phenyl-benzofurans as ER beta selective ligands. Bioorg Med Chem Lett. 2004 Oct 4;14(19):4925-9. DM38HKE RU https://pubmed.ncbi.nlm.nih.gov/15341953 DM9TZH4 DI DM9TZH4 DM9TZH4 DN 7-Chloro-2-phenyl-[1,8]naphthyridin-4-ol DM9TZH4 MI TTK25J1 DM9TZH4 MN Adenosine A1 receptor (ADORA1) DM9TZH4 MT DTT DM9TZH4 MA Inhibitor DM9TZH4 RN Study on affinity profile toward native human and bovine adenosine receptors of a series of 1,8-naphthyridine derivatives. J Med Chem. 2004 Jun 3;47(12):3019-31. DM9TZH4 RU https://pubmed.ncbi.nlm.nih.gov/15163184 DM3OMLU DI DM3OMLU DM3OMLU DN 7-chloro-3-hydroxyquinazoline-2,4-dione DM3OMLU MI TTAN6JD DM3OMLU MN Glutamate receptor AMPA (GRIA) DM3OMLU MT DTT DM3OMLU MA Inhibitor DM3OMLU RN Structural investigation of the 7-chloro-3-hydroxy-1H-quinazoline-2,4-dione scaffold to obtain AMPA and kainate receptor selective antagonists. Syn... J Med Chem. 2006 Oct 5;49(20):6015-26. DM3OMLU RU https://pubmed.ncbi.nlm.nih.gov/17004715 DM3OMLU DI DM3OMLU DM3OMLU DN 7-chloro-3-hydroxyquinazoline-2,4-dione DM3OMLU MI TTVPQTF DM3OMLU MN Glutamate receptor AMPA 1 (GRIA1) DM3OMLU MT DTT DM3OMLU MA Inhibitor DM3OMLU RN Structural investigation of the 7-chloro-3-hydroxy-1H-quinazoline-2,4-dione scaffold to obtain AMPA and kainate receptor selective antagonists. Syn... J Med Chem. 2006 Oct 5;49(20):6015-26. DM3OMLU RU https://pubmed.ncbi.nlm.nih.gov/17004715 DM3OMLU DI DM3OMLU DM3OMLU DN 7-chloro-3-hydroxyquinazoline-2,4-dione DM3OMLU MI TTLD29N DM3OMLU MN Glutamate receptor ionotropic NMDA 1 (NMDAR1) DM3OMLU MT DTT DM3OMLU MA Inhibitor DM3OMLU RN Structural investigation of the 7-chloro-3-hydroxy-1H-quinazoline-2,4-dione scaffold to obtain AMPA and kainate receptor selective antagonists. Syn... J Med Chem. 2006 Oct 5;49(20):6015-26. DM3OMLU RU https://pubmed.ncbi.nlm.nih.gov/17004715 DM3OMLU DI DM3OMLU DM3OMLU DN 7-chloro-3-hydroxyquinazoline-2,4-dione DM3OMLU MI TTKJEMQ DM3OMLU MN Glutamate receptor ionotropic NMDA 2A (NMDAR2A) DM3OMLU MT DTT DM3OMLU MA Inhibitor DM3OMLU RN Structural investigation of the 7-chloro-3-hydroxy-1H-quinazoline-2,4-dione scaffold to obtain AMPA and kainate receptor selective antagonists. Syn... J Med Chem. 2006 Oct 5;49(20):6015-26. DM3OMLU RU https://pubmed.ncbi.nlm.nih.gov/17004715 DM3OMLU DI DM3OMLU DM3OMLU DN 7-chloro-3-hydroxyquinazoline-2,4-dione DM3OMLU MI TTN9D8E DM3OMLU MN Glutamate receptor ionotropic NMDA 2B (NMDAR2B) DM3OMLU MT DTT DM3OMLU MA Inhibitor DM3OMLU RN Structural investigation of the 7-chloro-3-hydroxy-1H-quinazoline-2,4-dione scaffold to obtain AMPA and kainate receptor selective antagonists. Syn... J Med Chem. 2006 Oct 5;49(20):6015-26. DM3OMLU RU https://pubmed.ncbi.nlm.nih.gov/17004715 DM53A1R DI DM53A1R DM53A1R DN 7-Chloro-3-pyridin-4-yl-quinoline DM53A1R MI TT8FYO9 DM53A1R MN Platelet-derived growth factor receptor alpha (PDGFRA) DM53A1R MT DTT DM53A1R MA Inhibitor DM53A1R RN 5,7-Dimethoxy-3-(4-pyridinyl)quinoline is a potent and selective inhibitor of human vascular beta-type platelet-derived growth factor receptor tyro... J Med Chem. 1994 Aug 19;37(17):2627-9. DM53A1R RU https://pubmed.ncbi.nlm.nih.gov/8064792 DM53A1R DI DM53A1R DM53A1R DN 7-Chloro-3-pyridin-4-yl-quinoline DM53A1R MI TTI7421 DM53A1R MN Platelet-derived growth factor receptor beta (PDGFRB) DM53A1R MT DTT DM53A1R MA Inhibitor DM53A1R RN 5,7-Dimethoxy-3-(4-pyridinyl)quinoline is a potent and selective inhibitor of human vascular beta-type platelet-derived growth factor receptor tyro... J Med Chem. 1994 Aug 19;37(17):2627-9. DM53A1R RU https://pubmed.ncbi.nlm.nih.gov/8064792 DMRNZYQ DI DMRNZYQ DMRNZYQ DN 7-chloro-6H-chromeno[4,3-b]quinoline-3,9-diol DMRNZYQ MI TTPNQAC DMRNZYQ MN Estrogen-related receptor-alpha (ESRRA) DMRNZYQ MT DTT DMRNZYQ MA Inhibitor DMRNZYQ RN ERbeta ligands. Part 6: 6H-Chromeno[4,3-b]quinolines as a new series of estrogen receptor beta-selective ligands. Bioorg Med Chem Lett. 2007 Jul 15;17(14):4053-6. DMRNZYQ RU https://pubmed.ncbi.nlm.nih.gov/17482813 DM28NAB DI DM28NAB DM28NAB DN 7-chloroindirubin-3-oxime DM28NAB MI TT9RTBL DM28NAB MN Aurora B messenger RNA (AURKB mRNA) DM28NAB MT DTT DM28NAB MA Inhibitor DM28NAB RN An integrated computational approach to the phenomenon of potent and selective inhibition of aurora kinases B and C by a series of 7-substituted in... J Med Chem. 2007 Aug 23;50(17):4027-37. DM28NAB RU https://pubmed.ncbi.nlm.nih.gov/17665890 DM28NAB DI DM28NAB DM28NAB DN 7-chloroindirubin-3-oxime DM28NAB MI TTLYXIT DM28NAB MN Aurora kinase C (AURKC) DM28NAB MT DTT DM28NAB MA Inhibitor DM28NAB RN An integrated computational approach to the phenomenon of potent and selective inhibition of aurora kinases B and C by a series of 7-substituted in... J Med Chem. 2007 Aug 23;50(17):4027-37. DM28NAB RU https://pubmed.ncbi.nlm.nih.gov/17665890 DM2MIJY DI DM2MIJY DM2MIJY DN 7-Cyclopentyloxy-3-(4-hydroxyphenyl)chromen-4-one DM2MIJY MI TTZAYWL DM2MIJY MN Estrogen receptor (ESR) DM2MIJY MT DTT DM2MIJY MA Inhibitor DM2MIJY RN Effects of 7-O substitutions on estrogenic and anti-estrogenic activities of daidzein analogues in MCF-7 breast cancer cells. J Med Chem. 2010 Aug 26;53(16):6153-63. DM2MIJY RU https://pubmed.ncbi.nlm.nih.gov/20669983 DMANYSO DI DMANYSO DMANYSO DN 7-Diazonium-naphthalene-1-sulfonic acid anion DMANYSO MI TTNJYV2 DMANYSO MN Gamma-aminobutyric acid receptor (GAR) DMANYSO MT DTT DMANYSO MA Inhibitor DMANYSO RN Aryl diazo compounds and diazonium salts as potential irreversible probes of the gamma-aminobutyric acid receptor. J Med Chem. 1987 Dec;30(12):2222-7. DMANYSO RU https://pubmed.ncbi.nlm.nih.gov/2824775 DMNEAU0 DI DMNEAU0 DMNEAU0 DN 7-Dimethylamino-2-phenyl-[1,8]naphthyridin-4-ol DMNEAU0 MI TTK25J1 DMNEAU0 MN Adenosine A1 receptor (ADORA1) DMNEAU0 MT DTT DMNEAU0 MA Inhibitor DMNEAU0 RN Study on affinity profile toward native human and bovine adenosine receptors of a series of 1,8-naphthyridine derivatives. J Med Chem. 2004 Jun 3;47(12):3019-31. DMNEAU0 RU https://pubmed.ncbi.nlm.nih.gov/15163184 DMDY2PQ DI DMDY2PQ DMDY2PQ DN 7-Dimethylamino-3-methyl-hept-5-yn-2-one DMDY2PQ MI TTZ9SOR DMDY2PQ MN Muscarinic acetylcholine receptor M1 (CHRM1) DMDY2PQ MT DTT DMDY2PQ MA Inhibitor DMDY2PQ RN Cholinergic agents: aldehyde, ketone, and oxime analogues of the muscarinic agonist UH5, Bioorg. Med. Chem. Lett. 2(8):803-808 (1992). DMDY2PQ RU http://www.sciencedirect.com/science/article/pii/S0960894X00805351 DMDY2PQ DI DMDY2PQ DMDY2PQ DN 7-Dimethylamino-3-methyl-hept-5-yn-2-one DMDY2PQ MI TTYEG6Q DMDY2PQ MN Muscarinic acetylcholine receptor M2 (CHRM2) DMDY2PQ MT DTT DMDY2PQ MA Inhibitor DMDY2PQ RN Cholinergic agents: aldehyde, ketone, and oxime analogues of the muscarinic agonist UH5, Bioorg. Med. Chem. Lett. 2(8):803-808 (1992). DMDY2PQ RU http://www.sciencedirect.com/science/article/pii/S0960894X00805351 DMDY2PQ DI DMDY2PQ DMDY2PQ DN 7-Dimethylamino-3-methyl-hept-5-yn-2-one DMDY2PQ MI TTQ13Z5 DMDY2PQ MN Muscarinic acetylcholine receptor M3 (CHRM3) DMDY2PQ MT DTT DMDY2PQ MA Inhibitor DMDY2PQ RN Cholinergic agents: aldehyde, ketone, and oxime analogues of the muscarinic agonist UH5, Bioorg. Med. Chem. Lett. 2(8):803-808 (1992). DMDY2PQ RU http://www.sciencedirect.com/science/article/pii/S0960894X00805351 DMDY2PQ DI DMDY2PQ DMDY2PQ DN 7-Dimethylamino-3-methyl-hept-5-yn-2-one DMDY2PQ MI TTQ3JTF DMDY2PQ MN Muscarinic acetylcholine receptor M4 (CHRM4) DMDY2PQ MT DTT DMDY2PQ MA Inhibitor DMDY2PQ RN Cholinergic agents: aldehyde, ketone, and oxime analogues of the muscarinic agonist UH5, Bioorg. Med. Chem. Lett. 2(8):803-808 (1992). DMDY2PQ RU http://www.sciencedirect.com/science/article/pii/S0960894X00805351 DMDY2PQ DI DMDY2PQ DMDY2PQ DN 7-Dimethylamino-3-methyl-hept-5-yn-2-one DMDY2PQ MI TTH18TF DMDY2PQ MN Muscarinic acetylcholine receptor M5 (CHRM5) DMDY2PQ MT DTT DMDY2PQ MA Inhibitor DMDY2PQ RN Cholinergic agents: aldehyde, ketone, and oxime analogues of the muscarinic agonist UH5, Bioorg. Med. Chem. Lett. 2(8):803-808 (1992). DMDY2PQ RU http://www.sciencedirect.com/science/article/pii/S0960894X00805351 DMH782V DI DMH782V DMH782V DN 7-Dimethylamino-hept-5-yn-2-one DMH782V MI TTZ9SOR DMH782V MN Muscarinic acetylcholine receptor M1 (CHRM1) DMH782V MT DTT DMH782V MA Inhibitor DMH782V RN Cholinergic agents: aldehyde, ketone, and oxime analogues of the muscarinic agonist UH5, Bioorg. Med. Chem. Lett. 2(8):803-808 (1992). DMH782V RU http://www.sciencedirect.com/science/article/pii/S0960894X00805351 DMH782V DI DMH782V DMH782V DN 7-Dimethylamino-hept-5-yn-2-one DMH782V MI TTYEG6Q DMH782V MN Muscarinic acetylcholine receptor M2 (CHRM2) DMH782V MT DTT DMH782V MA Inhibitor DMH782V RN Cholinergic agents: aldehyde, ketone, and oxime analogues of the muscarinic agonist UH5, Bioorg. Med. Chem. Lett. 2(8):803-808 (1992). DMH782V RU http://www.sciencedirect.com/science/article/pii/S0960894X00805351 DMH782V DI DMH782V DMH782V DN 7-Dimethylamino-hept-5-yn-2-one DMH782V MI TTQ13Z5 DMH782V MN Muscarinic acetylcholine receptor M3 (CHRM3) DMH782V MT DTT DMH782V MA Inhibitor DMH782V RN Cholinergic agents: aldehyde, ketone, and oxime analogues of the muscarinic agonist UH5, Bioorg. Med. Chem. Lett. 2(8):803-808 (1992). DMH782V RU http://www.sciencedirect.com/science/article/pii/S0960894X00805351 DMH782V DI DMH782V DMH782V DN 7-Dimethylamino-hept-5-yn-2-one DMH782V MI TTQ3JTF DMH782V MN Muscarinic acetylcholine receptor M4 (CHRM4) DMH782V MT DTT DMH782V MA Inhibitor DMH782V RN Cholinergic agents: aldehyde, ketone, and oxime analogues of the muscarinic agonist UH5, Bioorg. Med. Chem. Lett. 2(8):803-808 (1992). DMH782V RU http://www.sciencedirect.com/science/article/pii/S0960894X00805351 DMH782V DI DMH782V DMH782V DN 7-Dimethylamino-hept-5-yn-2-one DMH782V MI TTH18TF DMH782V MN Muscarinic acetylcholine receptor M5 (CHRM5) DMH782V MT DTT DMH782V MA Inhibitor DMH782V RN Cholinergic agents: aldehyde, ketone, and oxime analogues of the muscarinic agonist UH5, Bioorg. Med. Chem. Lett. 2(8):803-808 (1992). DMH782V RU http://www.sciencedirect.com/science/article/pii/S0960894X00805351 DMRAZDW DI DMRAZDW DMRAZDW DN 7-epi-ginkgolide C DMRAZDW MI TTQL5VC DMRAZDW MN Platelet-activating factor receptor (PTAFR) DMRAZDW MT DTT DMRAZDW MA Antagonist DMRAZDW RN Preparation of 7-substituted ginkgolide derivatives: potent platelet activating factor (PAF) receptor antagonists. J Med Chem. 2003 Feb 13;46(4):601-8. DMRAZDW RU https://pubmed.ncbi.nlm.nih.gov/12570381 DMI16MD DI DMI16MD DMI16MD DN 7-Ethoxy-1,3-dihydro-imidazo[4,5-b]quinolin-2-one DMI16MD MI TT06AWU DMI16MD MN Phosphodiesterase 3A (PDE3A) DMI16MD MT DTT DMI16MD MA Inhibitor DMI16MD RN 1,3-Dihydro-2H-imidazo[4,5-b]quinolin-2-ones--inhibitors of blood platelet cAMP phosphodiesterase and induced aggregation. J Med Chem. 1991 Sep;34(9):2906-16. DMI16MD RU https://pubmed.ncbi.nlm.nih.gov/1654430 DMYJBPI DI DMYJBPI DMYJBPI DN 7-ethoxy-8-propionyl-2H-chromen-2-one DMYJBPI MI TT2LVK8 DMYJBPI MN Carbonic anhydrase IX (CA-IX) DMYJBPI MT DTT DMYJBPI MA Inhibitor DMYJBPI RN 7,8-disubstituted- but not 6,7-disubstituted coumarins selectively inhibit the transmembrane, tumor-associated carbonic anhydrase isoforms IX and X... Bioorg Med Chem Lett. 2010 Dec 15;20(24):7255-8. DMYJBPI RU https://pubmed.ncbi.nlm.nih.gov/21067924 DMUMN4B DI DMUMN4B DMUMN4B DN 7-Ethyl-2-(4-hydroxy-phenyl)-benzooxazol-5-ol DMUMN4B MI TTZAYWL DMUMN4B MN Estrogen receptor (ESR) DMUMN4B MT DTT DMUMN4B MA Inhibitor DMUMN4B RN Design and synthesis of aryl diphenolic azoles as potent and selective estrogen receptor-beta ligands. J Med Chem. 2004 Oct 7;47(21):5021-40. DMUMN4B RU https://pubmed.ncbi.nlm.nih.gov/15456246 DMUMN4B DI DMUMN4B DMUMN4B DN 7-Ethyl-2-(4-hydroxy-phenyl)-benzooxazol-5-ol DMUMN4B MI TTOM3J0 DMUMN4B MN Estrogen receptor beta (ESR2) DMUMN4B MT DTT DMUMN4B MA Inhibitor DMUMN4B RN Design and synthesis of aryl diphenolic azoles as potent and selective estrogen receptor-beta ligands. J Med Chem. 2004 Oct 7;47(21):5021-40. DMUMN4B RU https://pubmed.ncbi.nlm.nih.gov/15456246 DMSFODU DI DMSFODU DMSFODU DN 7-ethyl-6H-chromeno[4,3-b]quinoline-3,9-diol DMSFODU MI TTPNQAC DMSFODU MN Estrogen-related receptor-alpha (ESRRA) DMSFODU MT DTT DMSFODU MA Inhibitor DMSFODU RN ERbeta ligands. Part 6: 6H-Chromeno[4,3-b]quinolines as a new series of estrogen receptor beta-selective ligands. Bioorg Med Chem Lett. 2007 Jul 15;17(14):4053-6. DMSFODU RU https://pubmed.ncbi.nlm.nih.gov/17482813 DMXM2G7 DI DMXM2G7 DMXM2G7 DN 7-ethyloxyethoxy-2-morpholin-4-yl-chromen-4-one DMXM2G7 MI TTK3PY9 DMXM2G7 MN DNA-dependent protein kinase catalytic (PRKDC) DMXM2G7 MT DTT DMXM2G7 MA Inhibitor DMXM2G7 RN Discovery of potent chromen-4-one inhibitors of the DNA-dependent protein kinase (DNA-PK) using a small-molecule library approach. J Med Chem. 2005 Dec 1;48(24):7829-46. DMXM2G7 RU https://pubmed.ncbi.nlm.nih.gov/16302822 DM92EG5 DI DM92EG5 DM92EG5 DN 7-Ethynyl-2-(4-hydroxy-phenyl)-benzooxazol-5-ol DM92EG5 MI TTZAYWL DM92EG5 MN Estrogen receptor (ESR) DM92EG5 MT DTT DM92EG5 MA Inhibitor DM92EG5 RN Design and synthesis of aryl diphenolic azoles as potent and selective estrogen receptor-beta ligands. J Med Chem. 2004 Oct 7;47(21):5021-40. DM92EG5 RU https://pubmed.ncbi.nlm.nih.gov/15456246 DM92EG5 DI DM92EG5 DM92EG5 DN 7-Ethynyl-2-(4-hydroxy-phenyl)-benzooxazol-5-ol DM92EG5 MI TTOM3J0 DM92EG5 MN Estrogen receptor beta (ESR2) DM92EG5 MT DTT DM92EG5 MA Inhibitor DM92EG5 RN Design and synthesis of aryl diphenolic azoles as potent and selective estrogen receptor-beta ligands. J Med Chem. 2004 Oct 7;47(21):5021-40. DM92EG5 RU https://pubmed.ncbi.nlm.nih.gov/15456246 DMJWCAH DI DMJWCAH DMJWCAH DN 7-ethynyl-6H-chromeno[4,3-b]quinoline-3,9-diol DMJWCAH MI TTPNQAC DMJWCAH MN Estrogen-related receptor-alpha (ESRRA) DMJWCAH MT DTT DMJWCAH MA Inhibitor DMJWCAH RN ERbeta ligands. Part 6: 6H-Chromeno[4,3-b]quinolines as a new series of estrogen receptor beta-selective ligands. Bioorg Med Chem Lett. 2007 Jul 15;17(14):4053-6. DMJWCAH RU https://pubmed.ncbi.nlm.nih.gov/17482813 DMNRCDI DI DMNRCDI DMNRCDI DN 7-Fluoro-1,3-dihydro-imidazo[4,5-b]quinolin-2-one DMNRCDI MI TT06AWU DMNRCDI MN Phosphodiesterase 3A (PDE3A) DMNRCDI MT DTT DMNRCDI MA Inhibitor DMNRCDI RN 1,3-Dihydro-2H-imidazo[4,5-b]quinolin-2-ones--inhibitors of blood platelet cAMP phosphodiesterase and induced aggregation. J Med Chem. 1991 Sep;34(9):2906-16. DMNRCDI RU https://pubmed.ncbi.nlm.nih.gov/1654430 DM4HJZI DI DM4HJZI DM4HJZI DN 7-fluoro-2-(4-fluorophenyl)-4H-chromene-4-thione DM4HJZI MI TTGP7BY DM4HJZI MN Monoamine oxidase type B (MAO-B) DM4HJZI MT DTT DM4HJZI MA Inhibitor DM4HJZI RN A new series of flavones, thioflavones, and flavanones as selective monoamine oxidase-B inhibitors. Bioorg Med Chem. 2010 Feb;18(3):1273-9. DM4HJZI RU https://pubmed.ncbi.nlm.nih.gov/20045650 DMUPXBJ DI DMUPXBJ DMUPXBJ DN 7-fluoro-2-(4-methoxyphenyl)-4H-chromen-4-one DMUPXBJ MI TTGP7BY DMUPXBJ MN Monoamine oxidase type B (MAO-B) DMUPXBJ MT DTT DMUPXBJ MA Inhibitor DMUPXBJ RN A new series of flavones, thioflavones, and flavanones as selective monoamine oxidase-B inhibitors. Bioorg Med Chem. 2010 Feb;18(3):1273-9. DMUPXBJ RU https://pubmed.ncbi.nlm.nih.gov/20045650 DMFOU8G DI DMFOU8G DMFOU8G DN 7-fluoro-2-p-tolyl-4H-chromen-4-one DMFOU8G MI TTGP7BY DMFOU8G MN Monoamine oxidase type B (MAO-B) DMFOU8G MT DTT DMFOU8G MA Inhibitor DMFOU8G RN A new series of flavones, thioflavones, and flavanones as selective monoamine oxidase-B inhibitors. Bioorg Med Chem. 2010 Feb;18(3):1273-9. DMFOU8G RU https://pubmed.ncbi.nlm.nih.gov/20045650 DMJFXKA DI DMJFXKA DMJFXKA DN 7-fluoro-2-p-tolyl-4H-chromene-4-thione DMJFXKA MI TTGP7BY DMJFXKA MN Monoamine oxidase type B (MAO-B) DMJFXKA MT DTT DMJFXKA MA Inhibitor DMJFXKA RN A new series of flavones, thioflavones, and flavanones as selective monoamine oxidase-B inhibitors. Bioorg Med Chem. 2010 Feb;18(3):1273-9. DMJFXKA RU https://pubmed.ncbi.nlm.nih.gov/20045650 DM0QI8V DI DM0QI8V DM0QI8V DN 7-Fluoro-3-thiophen-3-yl-quinoline DM0QI8V MI TT8FYO9 DM0QI8V MN Platelet-derived growth factor receptor alpha (PDGFRA) DM0QI8V MT DTT DM0QI8V MA Inhibitor DM0QI8V RN A new series of PDGF receptor tyrosine kinase inhibitors: 3-substituted quinoline derivatives. J Med Chem. 1994 Jul 8;37(14):2129-37. DM0QI8V RU https://pubmed.ncbi.nlm.nih.gov/8035419 DM0QI8V DI DM0QI8V DM0QI8V DN 7-Fluoro-3-thiophen-3-yl-quinoline DM0QI8V MI TTI7421 DM0QI8V MN Platelet-derived growth factor receptor beta (PDGFRB) DM0QI8V MT DTT DM0QI8V MA Inhibitor DM0QI8V RN A new series of PDGF receptor tyrosine kinase inhibitors: 3-substituted quinoline derivatives. J Med Chem. 1994 Jul 8;37(14):2129-37. DM0QI8V RU https://pubmed.ncbi.nlm.nih.gov/8035419 DMQ2ZTJ DI DMQ2ZTJ DMQ2ZTJ DN 7-fluorochromone-2-carboxamide DMQ2ZTJ MI TTX4RTB DMQ2ZTJ MN Melanin-concentrating hormone receptor 1 (MCHR1) DMQ2ZTJ MT DTT DMQ2ZTJ MA Antagonist DMQ2ZTJ RN Optimization of chromone-2-carboxamide melanin concentrating hormone receptor 1 antagonists: assessment of potency, efficacy, and cardiovascular safety. J Med Chem. 2006 Nov 2;49(22):6569-84. DMQ2ZTJ RU https://pubmed.ncbi.nlm.nih.gov/17064075 DM70I3V DI DM70I3V DM70I3V DN 7-fluoroindirubin-3-acetoxime DM70I3V MI TT9RTBL DM70I3V MN Aurora B messenger RNA (AURKB mRNA) DM70I3V MT DTT DM70I3V MA Inhibitor DM70I3V RN An integrated computational approach to the phenomenon of potent and selective inhibition of aurora kinases B and C by a series of 7-substituted in... J Med Chem. 2007 Aug 23;50(17):4027-37. DM70I3V RU https://pubmed.ncbi.nlm.nih.gov/17665890 DM70I3V DI DM70I3V DM70I3V DN 7-fluoroindirubin-3-acetoxime DM70I3V MI TTLYXIT DM70I3V MN Aurora kinase C (AURKC) DM70I3V MT DTT DM70I3V MA Inhibitor DM70I3V RN An integrated computational approach to the phenomenon of potent and selective inhibition of aurora kinases B and C by a series of 7-substituted in... J Med Chem. 2007 Aug 23;50(17):4027-37. DM70I3V RU https://pubmed.ncbi.nlm.nih.gov/17665890 DMQD34N DI DMQD34N DMQD34N DN 7-fluoroindirubin-3-oxime DMQD34N MI TT9RTBL DMQD34N MN Aurora B messenger RNA (AURKB mRNA) DMQD34N MT DTT DMQD34N MA Inhibitor DMQD34N RN An integrated computational approach to the phenomenon of potent and selective inhibition of aurora kinases B and C by a series of 7-substituted in... J Med Chem. 2007 Aug 23;50(17):4027-37. DMQD34N RU https://pubmed.ncbi.nlm.nih.gov/17665890 DMQD34N DI DMQD34N DMQD34N DN 7-fluoroindirubin-3-oxime DMQD34N MI TTPS3C0 DMQD34N MN Aurora kinase A (AURKA) DMQD34N MT DTT DMQD34N MA Inhibitor DMQD34N RN An integrated computational approach to the phenomenon of potent and selective inhibition of aurora kinases B and C by a series of 7-substituted in... J Med Chem. 2007 Aug 23;50(17):4027-37. DMQD34N RU https://pubmed.ncbi.nlm.nih.gov/17665890 DMQD34N DI DMQD34N DMQD34N DN 7-fluoroindirubin-3-oxime DMQD34N MI TTLYXIT DMQD34N MN Aurora kinase C (AURKC) DMQD34N MT DTT DMQD34N MA Inhibitor DMQD34N RN An integrated computational approach to the phenomenon of potent and selective inhibition of aurora kinases B and C by a series of 7-substituted in... J Med Chem. 2007 Aug 23;50(17):4027-37. DMQD34N RU https://pubmed.ncbi.nlm.nih.gov/17665890 DMEGSZD DI DMEGSZD DMEGSZD DN 7H-Pyrrolo[3,2-f]quinazoline-1,3-diamine DMEGSZD MI TT9SL3Q DMEGSZD MN Polypeptide deformylase (PDF) DMEGSZD MT DTT DMEGSZD MA Inhibitor DMEGSZD RN High-affinity inhibitors of dihydrofolate reductase: antimicrobial and anticancer activities of 7,8-dialkyl-1,3-diaminopyrrolo[3,2-f]quinazolines w... J Med Chem. 1996 Feb 16;39(4):892-903. DMEGSZD RU https://pubmed.ncbi.nlm.nih.gov/8632413 DMKSJE3 DI DMKSJE3 DMKSJE3 DN 7-hydroxy-1,2,9,9a-tetrahydrofluoren-3-one DMKSJE3 MI TTOM3J0 DMKSJE3 MN Estrogen receptor beta (ESR2) DMKSJE3 MT DTT DMKSJE3 MA Inhibitor DMKSJE3 RN The discovery of tetrahydrofluorenones as a new class of estrogen receptor beta-subtype selective ligands. Bioorg Med Chem Lett. 2006 Jul 1;16(13):3489-94. DMKSJE3 RU https://pubmed.ncbi.nlm.nih.gov/16632357 DMXBUNV DI DMXBUNV DMXBUNV DN 7-hydroxy-2-(3-hydroxyphenyl)chroman-4-one DMXBUNV MI TTSZLWK DMXBUNV MN Aromatase (CYP19A1) DMXBUNV MT DTT DMXBUNV MA Inhibitor DMXBUNV RN New 7,8-benzoflavanones as potent aromatase inhibitors: synthesis and biological evaluation. Bioorg Med Chem. 2008 Feb 1;16(3):1474-80. DMXBUNV RU https://pubmed.ncbi.nlm.nih.gov/18042388 DMCB2IM DI DMCB2IM DMCB2IM DN 7-Hydroxy-2-(4-hydroxy-benzyl)-chromen-4-one DMCB2IM MI TTFBNVI DMCB2IM MN Aldose reductase (AKR1B1) DMCB2IM MT DTT DMCB2IM MA Inhibitor DMCB2IM RN 1-Benzopyran-4-one antioxidants as aldose reductase inhibitors. J Med Chem. 1999 Jun 3;42(11):1881-93. DMCB2IM RU https://pubmed.ncbi.nlm.nih.gov/10354396 DM2BV6P DI DM2BV6P DM2BV6P DN 7-Hydroxy-2-(4-methoxy-benzyl)-chromen-4-one DM2BV6P MI TTFBNVI DM2BV6P MN Aldose reductase (AKR1B1) DM2BV6P MT DTT DM2BV6P MA Inhibitor DM2BV6P RN 1-Benzopyran-4-one antioxidants as aldose reductase inhibitors. J Med Chem. 1999 Jun 3;42(11):1881-93. DM2BV6P RU https://pubmed.ncbi.nlm.nih.gov/10354396 DMIKSTL DI DMIKSTL DMIKSTL DN 7-hydroxy-2-(morpholin-4-yl)chromen-4-one DMIKSTL MI TTK3PY9 DMIKSTL MN DNA-dependent protein kinase catalytic (PRKDC) DMIKSTL MT DTT DMIKSTL MA Inhibitor DMIKSTL RN Discovery of potent chromen-4-one inhibitors of the DNA-dependent protein kinase (DNA-PK) using a small-molecule library approach. J Med Chem. 2005 Dec 1;48(24):7829-46. DMIKSTL RU https://pubmed.ncbi.nlm.nih.gov/16302822 DM4UW65 DI DM4UW65 DM4UW65 DN 7-hydroxy-2-phenylchroman-4-one DM4UW65 MI TTSZLWK DM4UW65 MN Aromatase (CYP19A1) DM4UW65 MT DTT DM4UW65 MA Inhibitor DM4UW65 RN New 7,8-benzoflavanones as potent aromatase inhibitors: synthesis and biological evaluation. Bioorg Med Chem. 2008 Feb 1;16(3):1474-80. DM4UW65 RU https://pubmed.ncbi.nlm.nih.gov/18042388 DMS2NZA DI DMS2NZA DMS2NZA DN 7-Hydroxy-3-(3-hydroxyphenyl)-1-naphthonitrile DMS2NZA MI TTIWB6L DMS2NZA MN Estradiol 17 beta-dehydrogenase 1 (17-beta-HSD1) DMS2NZA MT DTT DMS2NZA MA Inhibitor DMS2NZA RN Substituted 6-phenyl-2-naphthols. Potent and selective nonsteroidal inhibitors of 17beta-hydroxysteroid dehydrogenase type 1 (17beta-HSD1): design,... J Med Chem. 2008 Aug 14;51(15):4685-98. DMS2NZA RU https://pubmed.ncbi.nlm.nih.gov/18630892 DM46J2H DI DM46J2H DM46J2H DN 7-hydroxy-3-(4-hydroxyphenyl)-3H-quinazolin-4-one DM46J2H MI TTOM3J0 DM46J2H MN Estrogen receptor beta (ESR2) DM46J2H MT DTT DM46J2H MA Inhibitor DM46J2H RN Synthesis and characterization of 3-arylquinazolinone and 3-arylquinazolinethione derivatives as selective estrogen receptor beta modulators. J Med Chem. 2006 Apr 20;49(8):2440-55. DM46J2H RU https://pubmed.ncbi.nlm.nih.gov/16610787 DM2ZE8U DI DM2ZE8U DM2ZE8U DN 7-hydroxy-3-phenyl-2H-chromen-2-one DM2ZE8U MI TT6804T DM2ZE8U MN MIF messenger RNA (MIF mRNA) DM2ZE8U MT DTT DM2ZE8U MA Inhibitor DM2ZE8U RN Discovery of human macrophage migration inhibitory factor (MIF)-CD74 antagonists via virtual screening. J Med Chem. 2009 Jan 22;52(2):416-24. DM2ZE8U RU https://pubmed.ncbi.nlm.nih.gov/19090668 DM3T612 DI DM3T612 DM3T612 DN 7-Hydroxy-4-phenylcoumarin DM3T612 MI TTFBNVI DM3T612 MN Aldose reductase (AKR1B1) DM3T612 MT DTT DM3T612 MA Inhibitor DM3T612 RN 6,7-Dihydroxy-4-phenylcoumarin as inhibitor of aldose reductase 2. Bioorg Med Chem Lett. 2010 Oct 1;20(19):5630-3. DM3T612 RU https://pubmed.ncbi.nlm.nih.gov/20805028 DM49RWY DI DM49RWY DM49RWY DN 7-Hydroxy-6-nitro-2-phenyl-chromen-4-one DM49RWY MI TTFBNVI DM49RWY MN Aldose reductase (AKR1B1) DM49RWY MT DTT DM49RWY MA Inhibitor DM49RWY RN 1-Benzopyran-4-one antioxidants as aldose reductase inhibitors. J Med Chem. 1999 Jun 3;42(11):1881-93. DM49RWY RU https://pubmed.ncbi.nlm.nih.gov/10354396 DMQ3RVK DI DMQ3RVK DMQ3RVK DN 7-hydroxy-6-propionyl-2H-chromen-2-one DMQ3RVK MI TT2LVK8 DMQ3RVK MN Carbonic anhydrase IX (CA-IX) DMQ3RVK MT DTT DMQ3RVK MA Inhibitor DMQ3RVK RN 7,8-disubstituted- but not 6,7-disubstituted coumarins selectively inhibit the transmembrane, tumor-associated carbonic anhydrase isoforms IX and X... Bioorg Med Chem Lett. 2010 Dec 15;20(24):7255-8. DMQ3RVK RU https://pubmed.ncbi.nlm.nih.gov/21067924 DMFKSMW DI DMFKSMW DMFKSMW DN 7-hydroxy-8-propionyl-2H-chromen-2-one DMFKSMW MI TT2LVK8 DMFKSMW MN Carbonic anhydrase IX (CA-IX) DMFKSMW MT DTT DMFKSMW MA Inhibitor DMFKSMW RN 7,8-disubstituted- but not 6,7-disubstituted coumarins selectively inhibit the transmembrane, tumor-associated carbonic anhydrase isoforms IX and X... Bioorg Med Chem Lett. 2010 Dec 15;20(24):7255-8. DMFKSMW RU https://pubmed.ncbi.nlm.nih.gov/21067924 DMZXMB7 DI DMZXMB7 DMZXMB7 DN 7-hydroxycholesterol DMZXMB7 MI TT1TYN7 DMZXMB7 MN Nuclear receptor ROR-alpha (RORA) DMZXMB7 MT DTT DMZXMB7 MA Agonist DMZXMB7 RN Identification of natural ligands of retinoic acid receptor-related orphan receptor alpha ligand-binding domain expressed in Sf9 cells--a mass spectrometry approach. Anal Biochem. 2003 Dec 1;323(1):139-49. DMZXMB7 RU https://pubmed.ncbi.nlm.nih.gov/14622968 DMV0PT8 DI DMV0PT8 DMV0PT8 DN 7-hydroxycostunolide DMV0PT8 MI TTSXVID DMV0PT8 MN Nuclear factor NF-kappa-B (NFKB) DMV0PT8 MT DTT DMV0PT8 MA Inhibitor DMV0PT8 RN Development of a structural model for NF-kappaB inhibition of sesquiterpene lactones using self-organizing neural networks. J Med Chem. 2006 Apr 6;49(7):2241-52. DMV0PT8 RU https://pubmed.ncbi.nlm.nih.gov/16570920 DMTMNO7 DI DMTMNO7 DMTMNO7 DN 7-hydroxycoumarin DMTMNO7 MI TT2LVK8 DMTMNO7 MN Carbonic anhydrase IX (CA-IX) DMTMNO7 MT DTT DMTMNO7 MA Inhibitor DMTMNO7 RN 7,8-disubstituted- but not 6,7-disubstituted coumarins selectively inhibit the transmembrane, tumor-associated carbonic anhydrase isoforms IX and X... Bioorg Med Chem Lett. 2010 Dec 15;20(24):7255-8. DMTMNO7 RU https://pubmed.ncbi.nlm.nih.gov/21067924 DMTMNO7 DI DMTMNO7 DMTMNO7 DN 7-hydroxycoumarin DMTMNO7 MI TTFCJ7S DMTMNO7 MN G1/S-specific cyclin-D1 (CCND1) DMTMNO7 MT DTT DMTMNO7 MA Inhibitor DMTMNO7 RN Decrease of cyclin D1 in the human lung adenocarcinoma cell line A-427 by 7-hydroxycoumarin. Lung Cancer. 2001 Nov;34(2):185-94. DMTMNO7 RU https://pubmed.ncbi.nlm.nih.gov/11679177 DMV39XT DI DMV39XT DMV39XT DN 7-Hydroxy-Pyrazolo[4,3-D]Pyrimidine DMV39XT MI TTBL49X DMV39XT MN Plasmodium Hypoxanthine-guanine phosphoribosyltransferase (Malaria LACZ) DMV39XT MT DTT DMV39XT MA Inhibitor DMV39XT RN DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Nucleic Acids Res. 2011 Jan;39(Database issue):D1035-41. DMV39XT RU https://pubmed.ncbi.nlm.nih.gov/21059682 DM6K5NF DI DM6K5NF DM6K5NF DN 7-Iodo-1,5-dihydro-imidazo[2,1-b]quinazolin-2-one DM6K5NF MI TT06AWU DM6K5NF MN Phosphodiesterase 3A (PDE3A) DM6K5NF MT DTT DM6K5NF MA Inhibitor DM6K5NF RN Inhibitors of cyclic AMP phosphodiesterase. 3. Synthesis and biological evaluation of pyrido and imidazolyl analogues of 1,2,3,5-tetrahydro-2-oxoim... J Med Chem. 1988 Nov;31(11):2136-45. DM6K5NF RU https://pubmed.ncbi.nlm.nih.gov/2846839 DMNFI02 DI DMNFI02 DMNFI02 DN 7-iodoindirubin-3-oxime DMNFI02 MI TT9RTBL DMNFI02 MN Aurora B messenger RNA (AURKB mRNA) DMNFI02 MT DTT DMNFI02 MA Inhibitor DMNFI02 RN An integrated computational approach to the phenomenon of potent and selective inhibition of aurora kinases B and C by a series of 7-substituted in... J Med Chem. 2007 Aug 23;50(17):4027-37. DMNFI02 RU https://pubmed.ncbi.nlm.nih.gov/17665890 DMNFI02 DI DMNFI02 DMNFI02 DN 7-iodoindirubin-3-oxime DMNFI02 MI TTLYXIT DMNFI02 MN Aurora kinase C (AURKC) DMNFI02 MT DTT DMNFI02 MA Inhibitor DMNFI02 RN An integrated computational approach to the phenomenon of potent and selective inhibition of aurora kinases B and C by a series of 7-substituted in... J Med Chem. 2007 Aug 23;50(17):4027-37. DMNFI02 RU https://pubmed.ncbi.nlm.nih.gov/17665890 DMVSF0O DI DMVSF0O DMVSF0O DN 7-Isopropyl-7H-adenine DMVSF0O MI TTM2AOE DMVSF0O MN Adenosine A2a receptor (ADORA2A) DMVSF0O MT DTT DMVSF0O MA Inhibitor DMVSF0O RN 8-Bromo-9-alkyl adenine derivatives as tools for developing new adenosine A2A and A2B receptors ligands. Bioorg Med Chem. 2009 Apr 1;17(7):2812-22. DMVSF0O RU https://pubmed.ncbi.nlm.nih.gov/19282184 DMPYTHV DI DMPYTHV DMPYTHV DN 7-Mercapto-heptanoic acid benzothiazol-2-ylamide DMPYTHV MI TTBH0VX DMPYTHV MN Histone deacetylase (HDAC) DMPYTHV MT DTT DMPYTHV MA Inhibitor DMPYTHV RN Novel inhibitors of human histone deacetylases: design, synthesis, enzyme inhibition, and cancer cell growth inhibition of SAHA-based non-hydroxama... J Med Chem. 2005 Feb 24;48(4):1019-32. DMPYTHV RU https://pubmed.ncbi.nlm.nih.gov/15715470 DMPYTHV DI DMPYTHV DMPYTHV DN 7-Mercapto-heptanoic acid benzothiazol-2-ylamide DMPYTHV MI TT6R7JZ DMPYTHV MN Histone deacetylase 1 (HDAC1) DMPYTHV MT DTT DMPYTHV MA Inhibitor DMPYTHV RN Novel inhibitors of human histone deacetylases: design, synthesis, enzyme inhibition, and cancer cell growth inhibition of SAHA-based non-hydroxama... J Med Chem. 2005 Feb 24;48(4):1019-32. DMPYTHV RU https://pubmed.ncbi.nlm.nih.gov/15715470 DMPYTHV DI DMPYTHV DMPYTHV DN 7-Mercapto-heptanoic acid benzothiazol-2-ylamide DMPYTHV MI TTYHPU6 DMPYTHV MN Histone deacetylase 10 (HDAC10) DMPYTHV MT DTT DMPYTHV MA Inhibitor DMPYTHV RN Novel inhibitors of human histone deacetylases: design, synthesis, enzyme inhibition, and cancer cell growth inhibition of SAHA-based non-hydroxama... J Med Chem. 2005 Feb 24;48(4):1019-32. DMPYTHV RU https://pubmed.ncbi.nlm.nih.gov/15715470 DMPYTHV DI DMPYTHV DMPYTHV DN 7-Mercapto-heptanoic acid benzothiazol-2-ylamide DMPYTHV MI TTSHTOI DMPYTHV MN Histone deacetylase 2 (HDAC2) DMPYTHV MT DTT DMPYTHV MA Inhibitor DMPYTHV RN Novel inhibitors of human histone deacetylases: design, synthesis, enzyme inhibition, and cancer cell growth inhibition of SAHA-based non-hydroxama... J Med Chem. 2005 Feb 24;48(4):1019-32. DMPYTHV RU https://pubmed.ncbi.nlm.nih.gov/15715470 DMPYTHV DI DMPYTHV DMPYTHV DN 7-Mercapto-heptanoic acid benzothiazol-2-ylamide DMPYTHV MI TTTQGH8 DMPYTHV MN Histone deacetylase 4 (HDAC4) DMPYTHV MT DTT DMPYTHV MA Inhibitor DMPYTHV RN Novel inhibitors of human histone deacetylases: design, synthesis, enzyme inhibition, and cancer cell growth inhibition of SAHA-based non-hydroxama... J Med Chem. 2005 Feb 24;48(4):1019-32. DMPYTHV RU https://pubmed.ncbi.nlm.nih.gov/15715470 DMPYTHV DI DMPYTHV DMPYTHV DN 7-Mercapto-heptanoic acid benzothiazol-2-ylamide DMPYTHV MI TT5ZKDI DMPYTHV MN Histone deacetylase 6 (HDAC6) DMPYTHV MT DTT DMPYTHV MA Inhibitor DMPYTHV RN Novel inhibitors of human histone deacetylases: design, synthesis, enzyme inhibition, and cancer cell growth inhibition of SAHA-based non-hydroxama... J Med Chem. 2005 Feb 24;48(4):1019-32. DMPYTHV RU https://pubmed.ncbi.nlm.nih.gov/15715470 DMPYTHV DI DMPYTHV DMPYTHV DN 7-Mercapto-heptanoic acid benzothiazol-2-ylamide DMPYTHV MI TTT6LFV DMPYTHV MN Histone deacetylase 8 (HDAC8) DMPYTHV MT DTT DMPYTHV MA Inhibitor DMPYTHV RN Novel inhibitors of human histone deacetylases: design, synthesis, enzyme inhibition, and cancer cell growth inhibition of SAHA-based non-hydroxama... J Med Chem. 2005 Feb 24;48(4):1019-32. DMPYTHV RU https://pubmed.ncbi.nlm.nih.gov/15715470 DMEQKPO DI DMEQKPO DMEQKPO DN 7-Mercapto-heptanoic acid biphenyl-3-ylamide DMEQKPO MI TTBH0VX DMEQKPO MN Histone deacetylase (HDAC) DMEQKPO MT DTT DMEQKPO MA Inhibitor DMEQKPO RN Novel inhibitors of human histone deacetylases: design, synthesis, enzyme inhibition, and cancer cell growth inhibition of SAHA-based non-hydroxama... J Med Chem. 2005 Feb 24;48(4):1019-32. DMEQKPO RU https://pubmed.ncbi.nlm.nih.gov/15715470 DMEQKPO DI DMEQKPO DMEQKPO DN 7-Mercapto-heptanoic acid biphenyl-3-ylamide DMEQKPO MI TT6R7JZ DMEQKPO MN Histone deacetylase 1 (HDAC1) DMEQKPO MT DTT DMEQKPO MA Inhibitor DMEQKPO RN Novel inhibitors of human histone deacetylases: design, synthesis, enzyme inhibition, and cancer cell growth inhibition of SAHA-based non-hydroxama... J Med Chem. 2005 Feb 24;48(4):1019-32. DMEQKPO RU https://pubmed.ncbi.nlm.nih.gov/15715470 DMEQKPO DI DMEQKPO DMEQKPO DN 7-Mercapto-heptanoic acid biphenyl-3-ylamide DMEQKPO MI TTYHPU6 DMEQKPO MN Histone deacetylase 10 (HDAC10) DMEQKPO MT DTT DMEQKPO MA Inhibitor DMEQKPO RN Novel inhibitors of human histone deacetylases: design, synthesis, enzyme inhibition, and cancer cell growth inhibition of SAHA-based non-hydroxama... J Med Chem. 2005 Feb 24;48(4):1019-32. DMEQKPO RU https://pubmed.ncbi.nlm.nih.gov/15715470 DMEQKPO DI DMEQKPO DMEQKPO DN 7-Mercapto-heptanoic acid biphenyl-3-ylamide DMEQKPO MI TTSHTOI DMEQKPO MN Histone deacetylase 2 (HDAC2) DMEQKPO MT DTT DMEQKPO MA Inhibitor DMEQKPO RN Novel inhibitors of human histone deacetylases: design, synthesis, enzyme inhibition, and cancer cell growth inhibition of SAHA-based non-hydroxama... J Med Chem. 2005 Feb 24;48(4):1019-32. DMEQKPO RU https://pubmed.ncbi.nlm.nih.gov/15715470 DMEQKPO DI DMEQKPO DMEQKPO DN 7-Mercapto-heptanoic acid biphenyl-3-ylamide DMEQKPO MI TTTQGH8 DMEQKPO MN Histone deacetylase 4 (HDAC4) DMEQKPO MT DTT DMEQKPO MA Inhibitor DMEQKPO RN Novel inhibitors of human histone deacetylases: design, synthesis, enzyme inhibition, and cancer cell growth inhibition of SAHA-based non-hydroxama... J Med Chem. 2005 Feb 24;48(4):1019-32. DMEQKPO RU https://pubmed.ncbi.nlm.nih.gov/15715470 DMEQKPO DI DMEQKPO DMEQKPO DN 7-Mercapto-heptanoic acid biphenyl-3-ylamide DMEQKPO MI TT5ZKDI DMEQKPO MN Histone deacetylase 6 (HDAC6) DMEQKPO MT DTT DMEQKPO MA Inhibitor DMEQKPO RN Novel inhibitors of human histone deacetylases: design, synthesis, enzyme inhibition, and cancer cell growth inhibition of SAHA-based non-hydroxama... J Med Chem. 2005 Feb 24;48(4):1019-32. DMEQKPO RU https://pubmed.ncbi.nlm.nih.gov/15715470 DMEQKPO DI DMEQKPO DMEQKPO DN 7-Mercapto-heptanoic acid biphenyl-3-ylamide DMEQKPO MI TTT6LFV DMEQKPO MN Histone deacetylase 8 (HDAC8) DMEQKPO MT DTT DMEQKPO MA Inhibitor DMEQKPO RN Novel inhibitors of human histone deacetylases: design, synthesis, enzyme inhibition, and cancer cell growth inhibition of SAHA-based non-hydroxama... J Med Chem. 2005 Feb 24;48(4):1019-32. DMEQKPO RU https://pubmed.ncbi.nlm.nih.gov/15715470 DMJMOUK DI DMJMOUK DMJMOUK DN 7-Mercapto-heptanoic acid biphenyl-4-ylamide DMJMOUK MI TTBH0VX DMJMOUK MN Histone deacetylase (HDAC) DMJMOUK MT DTT DMJMOUK MA Inhibitor DMJMOUK RN Novel inhibitors of human histone deacetylases: design, synthesis, enzyme inhibition, and cancer cell growth inhibition of SAHA-based non-hydroxama... J Med Chem. 2005 Feb 24;48(4):1019-32. DMJMOUK RU https://pubmed.ncbi.nlm.nih.gov/15715470 DMJMOUK DI DMJMOUK DMJMOUK DN 7-Mercapto-heptanoic acid biphenyl-4-ylamide DMJMOUK MI TT6R7JZ DMJMOUK MN Histone deacetylase 1 (HDAC1) DMJMOUK MT DTT DMJMOUK MA Inhibitor DMJMOUK RN Novel inhibitors of human histone deacetylases: design, synthesis, enzyme inhibition, and cancer cell growth inhibition of SAHA-based non-hydroxama... J Med Chem. 2005 Feb 24;48(4):1019-32. DMJMOUK RU https://pubmed.ncbi.nlm.nih.gov/15715470 DMJMOUK DI DMJMOUK DMJMOUK DN 7-Mercapto-heptanoic acid biphenyl-4-ylamide DMJMOUK MI TTYHPU6 DMJMOUK MN Histone deacetylase 10 (HDAC10) DMJMOUK MT DTT DMJMOUK MA Inhibitor DMJMOUK RN Novel inhibitors of human histone deacetylases: design, synthesis, enzyme inhibition, and cancer cell growth inhibition of SAHA-based non-hydroxama... J Med Chem. 2005 Feb 24;48(4):1019-32. DMJMOUK RU https://pubmed.ncbi.nlm.nih.gov/15715470 DMJMOUK DI DMJMOUK DMJMOUK DN 7-Mercapto-heptanoic acid biphenyl-4-ylamide DMJMOUK MI TTSHTOI DMJMOUK MN Histone deacetylase 2 (HDAC2) DMJMOUK MT DTT DMJMOUK MA Inhibitor DMJMOUK RN Novel inhibitors of human histone deacetylases: design, synthesis, enzyme inhibition, and cancer cell growth inhibition of SAHA-based non-hydroxama... J Med Chem. 2005 Feb 24;48(4):1019-32. DMJMOUK RU https://pubmed.ncbi.nlm.nih.gov/15715470 DMJMOUK DI DMJMOUK DMJMOUK DN 7-Mercapto-heptanoic acid biphenyl-4-ylamide DMJMOUK MI TTTQGH8 DMJMOUK MN Histone deacetylase 4 (HDAC4) DMJMOUK MT DTT DMJMOUK MA Inhibitor DMJMOUK RN Novel inhibitors of human histone deacetylases: design, synthesis, enzyme inhibition, and cancer cell growth inhibition of SAHA-based non-hydroxama... J Med Chem. 2005 Feb 24;48(4):1019-32. DMJMOUK RU https://pubmed.ncbi.nlm.nih.gov/15715470 DMJMOUK DI DMJMOUK DMJMOUK DN 7-Mercapto-heptanoic acid biphenyl-4-ylamide DMJMOUK MI TT5ZKDI DMJMOUK MN Histone deacetylase 6 (HDAC6) DMJMOUK MT DTT DMJMOUK MA Inhibitor DMJMOUK RN Novel inhibitors of human histone deacetylases: design, synthesis, enzyme inhibition, and cancer cell growth inhibition of SAHA-based non-hydroxama... J Med Chem. 2005 Feb 24;48(4):1019-32. DMJMOUK RU https://pubmed.ncbi.nlm.nih.gov/15715470 DMJMOUK DI DMJMOUK DMJMOUK DN 7-Mercapto-heptanoic acid biphenyl-4-ylamide DMJMOUK MI TTT6LFV DMJMOUK MN Histone deacetylase 8 (HDAC8) DMJMOUK MT DTT DMJMOUK MA Inhibitor DMJMOUK RN Novel inhibitors of human histone deacetylases: design, synthesis, enzyme inhibition, and cancer cell growth inhibition of SAHA-based non-hydroxama... J Med Chem. 2005 Feb 24;48(4):1019-32. DMJMOUK RU https://pubmed.ncbi.nlm.nih.gov/15715470 DM4912P DI DM4912P DM4912P DN 7-Mercapto-heptanoic acid phenylamide DM4912P MI TTBH0VX DM4912P MN Histone deacetylase (HDAC) DM4912P MT DTT DM4912P MA Inhibitor DM4912P RN Novel inhibitors of human histone deacetylases: design, synthesis, enzyme inhibition, and cancer cell growth inhibition of SAHA-based non-hydroxama... J Med Chem. 2005 Feb 24;48(4):1019-32. DM4912P RU https://pubmed.ncbi.nlm.nih.gov/15715470 DM4912P DI DM4912P DM4912P DN 7-Mercapto-heptanoic acid phenylamide DM4912P MI TT6R7JZ DM4912P MN Histone deacetylase 1 (HDAC1) DM4912P MT DTT DM4912P MA Inhibitor DM4912P RN Novel inhibitors of human histone deacetylases: design, synthesis, enzyme inhibition, and cancer cell growth inhibition of SAHA-based non-hydroxama... J Med Chem. 2005 Feb 24;48(4):1019-32. DM4912P RU https://pubmed.ncbi.nlm.nih.gov/15715470 DM4912P DI DM4912P DM4912P DN 7-Mercapto-heptanoic acid phenylamide DM4912P MI TTYHPU6 DM4912P MN Histone deacetylase 10 (HDAC10) DM4912P MT DTT DM4912P MA Inhibitor DM4912P RN Novel inhibitors of human histone deacetylases: design, synthesis, enzyme inhibition, and cancer cell growth inhibition of SAHA-based non-hydroxama... J Med Chem. 2005 Feb 24;48(4):1019-32. DM4912P RU https://pubmed.ncbi.nlm.nih.gov/15715470 DM4912P DI DM4912P DM4912P DN 7-Mercapto-heptanoic acid phenylamide DM4912P MI TTSHTOI DM4912P MN Histone deacetylase 2 (HDAC2) DM4912P MT DTT DM4912P MA Inhibitor DM4912P RN Novel inhibitors of human histone deacetylases: design, synthesis, enzyme inhibition, and cancer cell growth inhibition of SAHA-based non-hydroxama... J Med Chem. 2005 Feb 24;48(4):1019-32. DM4912P RU https://pubmed.ncbi.nlm.nih.gov/15715470 DM4912P DI DM4912P DM4912P DN 7-Mercapto-heptanoic acid phenylamide DM4912P MI TTTQGH8 DM4912P MN Histone deacetylase 4 (HDAC4) DM4912P MT DTT DM4912P MA Inhibitor DM4912P RN Novel inhibitors of human histone deacetylases: design, synthesis, enzyme inhibition, and cancer cell growth inhibition of SAHA-based non-hydroxama... J Med Chem. 2005 Feb 24;48(4):1019-32. DM4912P RU https://pubmed.ncbi.nlm.nih.gov/15715470 DM4912P DI DM4912P DM4912P DN 7-Mercapto-heptanoic acid phenylamide DM4912P MI TT5ZKDI DM4912P MN Histone deacetylase 6 (HDAC6) DM4912P MT DTT DM4912P MA Inhibitor DM4912P RN Novel inhibitors of human histone deacetylases: design, synthesis, enzyme inhibition, and cancer cell growth inhibition of SAHA-based non-hydroxama... J Med Chem. 2005 Feb 24;48(4):1019-32. DM4912P RU https://pubmed.ncbi.nlm.nih.gov/15715470 DM4912P DI DM4912P DM4912P DN 7-Mercapto-heptanoic acid phenylamide DM4912P MI TTT6LFV DM4912P MN Histone deacetylase 8 (HDAC8) DM4912P MT DTT DM4912P MA Inhibitor DM4912P RN Novel inhibitors of human histone deacetylases: design, synthesis, enzyme inhibition, and cancer cell growth inhibition of SAHA-based non-hydroxama... J Med Chem. 2005 Feb 24;48(4):1019-32. DM4912P RU https://pubmed.ncbi.nlm.nih.gov/15715470 DMQ9PLA DI DMQ9PLA DMQ9PLA DN 7-Mercapto-heptanoic acid pyridin-3-ylamide DMQ9PLA MI TTBH0VX DMQ9PLA MN Histone deacetylase (HDAC) DMQ9PLA MT DTT DMQ9PLA MA Inhibitor DMQ9PLA RN Novel inhibitors of human histone deacetylases: design, synthesis, enzyme inhibition, and cancer cell growth inhibition of SAHA-based non-hydroxama... J Med Chem. 2005 Feb 24;48(4):1019-32. DMQ9PLA RU https://pubmed.ncbi.nlm.nih.gov/15715470 DMQ9PLA DI DMQ9PLA DMQ9PLA DN 7-Mercapto-heptanoic acid pyridin-3-ylamide DMQ9PLA MI TT6R7JZ DMQ9PLA MN Histone deacetylase 1 (HDAC1) DMQ9PLA MT DTT DMQ9PLA MA Inhibitor DMQ9PLA RN Novel inhibitors of human histone deacetylases: design, synthesis, enzyme inhibition, and cancer cell growth inhibition of SAHA-based non-hydroxama... J Med Chem. 2005 Feb 24;48(4):1019-32. DMQ9PLA RU https://pubmed.ncbi.nlm.nih.gov/15715470 DMQ9PLA DI DMQ9PLA DMQ9PLA DN 7-Mercapto-heptanoic acid pyridin-3-ylamide DMQ9PLA MI TTYHPU6 DMQ9PLA MN Histone deacetylase 10 (HDAC10) DMQ9PLA MT DTT DMQ9PLA MA Inhibitor DMQ9PLA RN Novel inhibitors of human histone deacetylases: design, synthesis, enzyme inhibition, and cancer cell growth inhibition of SAHA-based non-hydroxama... J Med Chem. 2005 Feb 24;48(4):1019-32. DMQ9PLA RU https://pubmed.ncbi.nlm.nih.gov/15715470 DMQ9PLA DI DMQ9PLA DMQ9PLA DN 7-Mercapto-heptanoic acid pyridin-3-ylamide DMQ9PLA MI TTSHTOI DMQ9PLA MN Histone deacetylase 2 (HDAC2) DMQ9PLA MT DTT DMQ9PLA MA Inhibitor DMQ9PLA RN Novel inhibitors of human histone deacetylases: design, synthesis, enzyme inhibition, and cancer cell growth inhibition of SAHA-based non-hydroxama... J Med Chem. 2005 Feb 24;48(4):1019-32. DMQ9PLA RU https://pubmed.ncbi.nlm.nih.gov/15715470 DMQ9PLA DI DMQ9PLA DMQ9PLA DN 7-Mercapto-heptanoic acid pyridin-3-ylamide DMQ9PLA MI TTTQGH8 DMQ9PLA MN Histone deacetylase 4 (HDAC4) DMQ9PLA MT DTT DMQ9PLA MA Inhibitor DMQ9PLA RN Novel inhibitors of human histone deacetylases: design, synthesis, enzyme inhibition, and cancer cell growth inhibition of SAHA-based non-hydroxama... J Med Chem. 2005 Feb 24;48(4):1019-32. DMQ9PLA RU https://pubmed.ncbi.nlm.nih.gov/15715470 DMQ9PLA DI DMQ9PLA DMQ9PLA DN 7-Mercapto-heptanoic acid pyridin-3-ylamide DMQ9PLA MI TT5ZKDI DMQ9PLA MN Histone deacetylase 6 (HDAC6) DMQ9PLA MT DTT DMQ9PLA MA Inhibitor DMQ9PLA RN Novel inhibitors of human histone deacetylases: design, synthesis, enzyme inhibition, and cancer cell growth inhibition of SAHA-based non-hydroxama... J Med Chem. 2005 Feb 24;48(4):1019-32. DMQ9PLA RU https://pubmed.ncbi.nlm.nih.gov/15715470 DMQ9PLA DI DMQ9PLA DMQ9PLA DN 7-Mercapto-heptanoic acid pyridin-3-ylamide DMQ9PLA MI TTT6LFV DMQ9PLA MN Histone deacetylase 8 (HDAC8) DMQ9PLA MT DTT DMQ9PLA MA Inhibitor DMQ9PLA RN Novel inhibitors of human histone deacetylases: design, synthesis, enzyme inhibition, and cancer cell growth inhibition of SAHA-based non-hydroxama... J Med Chem. 2005 Feb 24;48(4):1019-32. DMQ9PLA RU https://pubmed.ncbi.nlm.nih.gov/15715470 DMTAGJ1 DI DMTAGJ1 DMTAGJ1 DN 7-Mercapto-heptanoic acid quinolin-3-ylamide DMTAGJ1 MI TTBH0VX DMTAGJ1 MN Histone deacetylase (HDAC) DMTAGJ1 MT DTT DMTAGJ1 MA Inhibitor DMTAGJ1 RN Novel inhibitors of human histone deacetylases: design, synthesis, enzyme inhibition, and cancer cell growth inhibition of SAHA-based non-hydroxama... J Med Chem. 2005 Feb 24;48(4):1019-32. DMTAGJ1 RU https://pubmed.ncbi.nlm.nih.gov/15715470 DMTAGJ1 DI DMTAGJ1 DMTAGJ1 DN 7-Mercapto-heptanoic acid quinolin-3-ylamide DMTAGJ1 MI TT6R7JZ DMTAGJ1 MN Histone deacetylase 1 (HDAC1) DMTAGJ1 MT DTT DMTAGJ1 MA Inhibitor DMTAGJ1 RN Novel inhibitors of human histone deacetylases: design, synthesis, enzyme inhibition, and cancer cell growth inhibition of SAHA-based non-hydroxama... J Med Chem. 2005 Feb 24;48(4):1019-32. DMTAGJ1 RU https://pubmed.ncbi.nlm.nih.gov/15715470 DMTAGJ1 DI DMTAGJ1 DMTAGJ1 DN 7-Mercapto-heptanoic acid quinolin-3-ylamide DMTAGJ1 MI TTYHPU6 DMTAGJ1 MN Histone deacetylase 10 (HDAC10) DMTAGJ1 MT DTT DMTAGJ1 MA Inhibitor DMTAGJ1 RN Novel inhibitors of human histone deacetylases: design, synthesis, enzyme inhibition, and cancer cell growth inhibition of SAHA-based non-hydroxama... J Med Chem. 2005 Feb 24;48(4):1019-32. DMTAGJ1 RU https://pubmed.ncbi.nlm.nih.gov/15715470 DMTAGJ1 DI DMTAGJ1 DMTAGJ1 DN 7-Mercapto-heptanoic acid quinolin-3-ylamide DMTAGJ1 MI TTSHTOI DMTAGJ1 MN Histone deacetylase 2 (HDAC2) DMTAGJ1 MT DTT DMTAGJ1 MA Inhibitor DMTAGJ1 RN Novel inhibitors of human histone deacetylases: design, synthesis, enzyme inhibition, and cancer cell growth inhibition of SAHA-based non-hydroxama... J Med Chem. 2005 Feb 24;48(4):1019-32. DMTAGJ1 RU https://pubmed.ncbi.nlm.nih.gov/15715470 DMTAGJ1 DI DMTAGJ1 DMTAGJ1 DN 7-Mercapto-heptanoic acid quinolin-3-ylamide DMTAGJ1 MI TTTQGH8 DMTAGJ1 MN Histone deacetylase 4 (HDAC4) DMTAGJ1 MT DTT DMTAGJ1 MA Inhibitor DMTAGJ1 RN Novel inhibitors of human histone deacetylases: design, synthesis, enzyme inhibition, and cancer cell growth inhibition of SAHA-based non-hydroxama... J Med Chem. 2005 Feb 24;48(4):1019-32. DMTAGJ1 RU https://pubmed.ncbi.nlm.nih.gov/15715470 DMTAGJ1 DI DMTAGJ1 DMTAGJ1 DN 7-Mercapto-heptanoic acid quinolin-3-ylamide DMTAGJ1 MI TT5ZKDI DMTAGJ1 MN Histone deacetylase 6 (HDAC6) DMTAGJ1 MT DTT DMTAGJ1 MA Inhibitor DMTAGJ1 RN Novel inhibitors of human histone deacetylases: design, synthesis, enzyme inhibition, and cancer cell growth inhibition of SAHA-based non-hydroxama... J Med Chem. 2005 Feb 24;48(4):1019-32. DMTAGJ1 RU https://pubmed.ncbi.nlm.nih.gov/15715470 DMTAGJ1 DI DMTAGJ1 DMTAGJ1 DN 7-Mercapto-heptanoic acid quinolin-3-ylamide DMTAGJ1 MI TTT6LFV DMTAGJ1 MN Histone deacetylase 8 (HDAC8) DMTAGJ1 MT DTT DMTAGJ1 MA Inhibitor DMTAGJ1 RN Novel inhibitors of human histone deacetylases: design, synthesis, enzyme inhibition, and cancer cell growth inhibition of SAHA-based non-hydroxama... J Med Chem. 2005 Feb 24;48(4):1019-32. DMTAGJ1 RU https://pubmed.ncbi.nlm.nih.gov/15715470 DM03XYF DI DM03XYF DM03XYF DN 7-mercapto-N-(4-phenylthiazol-2-yl)heptanamide DM03XYF MI TT6R7JZ DM03XYF MN Histone deacetylase 1 (HDAC1) DM03XYF MT DTT DM03XYF MA Inhibitor DM03XYF RN Design, synthesis, structure--selectivity relationship, and effect on human cancer cells of a novel series of histone deacetylase 6-selective inhib... J Med Chem. 2007 Nov 1;50(22):5425-38. DM03XYF RU https://pubmed.ncbi.nlm.nih.gov/17929798 DM03XYF DI DM03XYF DM03XYF DN 7-mercapto-N-(4-phenylthiazol-2-yl)heptanamide DM03XYF MI TTTQGH8 DM03XYF MN Histone deacetylase 4 (HDAC4) DM03XYF MT DTT DM03XYF MA Inhibitor DM03XYF RN Design, synthesis, structure--selectivity relationship, and effect on human cancer cells of a novel series of histone deacetylase 6-selective inhib... J Med Chem. 2007 Nov 1;50(22):5425-38. DM03XYF RU https://pubmed.ncbi.nlm.nih.gov/17929798 DM03XYF DI DM03XYF DM03XYF DN 7-mercapto-N-(4-phenylthiazol-2-yl)heptanamide DM03XYF MI TT5ZKDI DM03XYF MN Histone deacetylase 6 (HDAC6) DM03XYF MT DTT DM03XYF MA Inhibitor DM03XYF RN Design, synthesis, structure--selectivity relationship, and effect on human cancer cells of a novel series of histone deacetylase 6-selective inhib... J Med Chem. 2007 Nov 1;50(22):5425-38. DM03XYF RU https://pubmed.ncbi.nlm.nih.gov/17929798 DMTFBCU DI DMTFBCU DMTFBCU DN 7-Methoxy-1H-indazole DMTFBCU MI TTZUFI5 DMTFBCU MN Nitric-oxide synthase brain (NOS1) DMTFBCU MT DTT DMTFBCU MA Inhibitor DMTFBCU RN Inhibition of neuronal nitric oxide synthase by 7-methoxyindazole and related substituted indazoles. Bioorg Med Chem Lett. 2001 May 7;11(9):1153-6. DMTFBCU RU https://pubmed.ncbi.nlm.nih.gov/11354365 DM3MXI5 DI DM3MXI5 DM3MXI5 DN 7-methoxy-1-naphthylpiperazine DM3MXI5 MI TTSQIFT DM3MXI5 MN 5-HT 1A receptor (HTR1A) DM3MXI5 MT DTT DM3MXI5 MA Agonist DM3MXI5 RN 5-HT1B receptor antagonist properties of novel arylpiperazide derivatives of 1-naphthylpiperazine. J Med Chem. 1997 Nov 21;40(24):3974-8. DM3MXI5 RU https://pubmed.ncbi.nlm.nih.gov/9397179 DM3MXI5 DI DM3MXI5 DM3MXI5 DN 7-methoxy-1-naphthylpiperazine DM3MXI5 MI TTK8CXU DM3MXI5 MN 5-HT 1B receptor (HTR1B) DM3MXI5 MT DTT DM3MXI5 MA Agonist DM3MXI5 RN 5-HT1B receptor antagonist properties of novel arylpiperazide derivatives of 1-naphthylpiperazine. J Med Chem. 1997 Nov 21;40(24):3974-8. DM3MXI5 RU https://pubmed.ncbi.nlm.nih.gov/9397179 DM3MXI5 DI DM3MXI5 DM3MXI5 DN 7-methoxy-1-naphthylpiperazine DM3MXI5 MI TT6MSOK DM3MXI5 MN 5-HT 1D receptor (HTR1D) DM3MXI5 MT DTT DM3MXI5 MA Agonist DM3MXI5 RN 5-HT1B receptor antagonist properties of novel arylpiperazide derivatives of 1-naphthylpiperazine. J Med Chem. 1997 Nov 21;40(24):3974-8. DM3MXI5 RU https://pubmed.ncbi.nlm.nih.gov/9397179 DMQ1BE8 DI DMQ1BE8 DMQ1BE8 DN 7-Methoxy-2,3,4,9-tetrahydro-1H-beta-carboline DMQ1BE8 MI TTJQOD7 DMQ1BE8 MN 5-HT 2A receptor (HTR2A) DMQ1BE8 MT DTT DMQ1BE8 MA Inhibitor DMQ1BE8 RN Binding of beta-carbolines at 5-HT(2) serotonin receptors. Bioorg Med Chem Lett. 2003 Dec 15;13(24):4421-5. DMQ1BE8 RU https://pubmed.ncbi.nlm.nih.gov/14643338 DMQ1BE8 DI DMQ1BE8 DMQ1BE8 DN 7-Methoxy-2,3,4,9-tetrahydro-1H-beta-carboline DMQ1BE8 MI TTWG9A4 DMQ1BE8 MN Adrenergic receptor alpha-2A (ADRA2A) DMQ1BE8 MT DTT DMQ1BE8 MA Inhibitor DMQ1BE8 RN Binding of an imidazopyridoindole at imidazoline I2 receptors. Bioorg Med Chem Lett. 2004 Jan 19;14(2):527-9. DMQ1BE8 RU https://pubmed.ncbi.nlm.nih.gov/14698196 DMQ1BE8 DI DMQ1BE8 DMQ1BE8 DN 7-Methoxy-2,3,4,9-tetrahydro-1H-beta-carboline DMQ1BE8 MI TTWM4TY DMQ1BE8 MN Adrenergic receptor alpha-2B (ADRA2B) DMQ1BE8 MT DTT DMQ1BE8 MA Inhibitor DMQ1BE8 RN Binding of an imidazopyridoindole at imidazoline I2 receptors. Bioorg Med Chem Lett. 2004 Jan 19;14(2):527-9. DMQ1BE8 RU https://pubmed.ncbi.nlm.nih.gov/14698196 DMQ1BE8 DI DMQ1BE8 DMQ1BE8 DN 7-Methoxy-2,3,4,9-tetrahydro-1H-beta-carboline DMQ1BE8 MI TT2NUT5 DMQ1BE8 MN Adrenergic receptor alpha-2C (ADRA2C) DMQ1BE8 MT DTT DMQ1BE8 MA Inhibitor DMQ1BE8 RN Binding of an imidazopyridoindole at imidazoline I2 receptors. Bioorg Med Chem Lett. 2004 Jan 19;14(2):527-9. DMQ1BE8 RU https://pubmed.ncbi.nlm.nih.gov/14698196 DMQ1BE8 DI DMQ1BE8 DMQ1BE8 DN 7-Methoxy-2,3,4,9-tetrahydro-1H-beta-carboline DMQ1BE8 MI TT3WG5C DMQ1BE8 MN Monoamine oxidase type A (MAO-A) DMQ1BE8 MT DTT DMQ1BE8 MA Inhibitor DMQ1BE8 RN Binding of an imidazopyridoindole at imidazoline I2 receptors. Bioorg Med Chem Lett. 2004 Jan 19;14(2):527-9. DMQ1BE8 RU https://pubmed.ncbi.nlm.nih.gov/14698196 DMQ1BE8 DI DMQ1BE8 DMQ1BE8 DN 7-Methoxy-2,3,4,9-tetrahydro-1H-beta-carboline DMQ1BE8 MI TTGP7BY DMQ1BE8 MN Monoamine oxidase type B (MAO-B) DMQ1BE8 MT DTT DMQ1BE8 MA Inhibitor DMQ1BE8 RN Binding of an imidazopyridoindole at imidazoline I2 receptors. Bioorg Med Chem Lett. 2004 Jan 19;14(2):527-9. DMQ1BE8 RU https://pubmed.ncbi.nlm.nih.gov/14698196 DMR713M DI DMR713M DMR713M DN 7-Methoxy-2-morpholin-4-yl-chromen-4-one DMR713M MI TTK3PY9 DMR713M MN DNA-dependent protein kinase catalytic (PRKDC) DMR713M MT DTT DMR713M MA Inhibitor DMR713M RN Selective benzopyranone and pyrimido[2,1-a]isoquinolin-4-one inhibitors of DNA-dependent protein kinase: synthesis, structure-activity studies, and... J Med Chem. 2005 Jan 27;48(2):569-85. DMR713M RU https://pubmed.ncbi.nlm.nih.gov/15658870 DMJITU0 DI DMJITU0 DMJITU0 DN 7-methoxy-2-oxo-2H-chromene-4-carboxylic acid DMJITU0 MI TTUNARX DMJITU0 MN Carbonic anhydrase (CA) DMJITU0 MT DTT DMJITU0 MA Inhibitor DMJITU0 RN Deciphering the mechanism of carbonic anhydrase inhibition with coumarins and thiocoumarins. J Med Chem. 2010 Jan 14;53(1):335-44. DMJITU0 RU https://pubmed.ncbi.nlm.nih.gov/19911821 DMJITU0 DI DMJITU0 DMJITU0 DN 7-methoxy-2-oxo-2H-chromene-4-carboxylic acid DMJITU0 MI TTHQPL7 DMJITU0 MN Carbonic anhydrase I (CA-I) DMJITU0 MT DTT DMJITU0 MA Inhibitor DMJITU0 RN Deciphering the mechanism of carbonic anhydrase inhibition with coumarins and thiocoumarins. J Med Chem. 2010 Jan 14;53(1):335-44. DMJITU0 RU https://pubmed.ncbi.nlm.nih.gov/19911821 DMJITU0 DI DMJITU0 DMJITU0 DN 7-methoxy-2-oxo-2H-chromene-4-carboxylic acid DMJITU0 MI TT2LVK8 DMJITU0 MN Carbonic anhydrase IX (CA-IX) DMJITU0 MT DTT DMJITU0 MA Inhibitor DMJITU0 RN Deciphering the mechanism of carbonic anhydrase inhibition with coumarins and thiocoumarins. J Med Chem. 2010 Jan 14;53(1):335-44. DMJITU0 RU https://pubmed.ncbi.nlm.nih.gov/19911821 DMJITU0 DI DMJITU0 DMJITU0 DN 7-methoxy-2-oxo-2H-chromene-4-carboxylic acid DMJITU0 MI TTSYM0R DMJITU0 MN Carbonic anhydrase XII (CA-XII) DMJITU0 MT DTT DMJITU0 MA Inhibitor DMJITU0 RN Deciphering the mechanism of carbonic anhydrase inhibition with coumarins and thiocoumarins. J Med Chem. 2010 Jan 14;53(1):335-44. DMJITU0 RU https://pubmed.ncbi.nlm.nih.gov/19911821 DMJITU0 DI DMJITU0 DMJITU0 DN 7-methoxy-2-oxo-2H-chromene-4-carboxylic acid DMJITU0 MI TTEYTKG DMJITU0 MN Carbonic anhydrase XIV (CA-XIV) DMJITU0 MT DTT DMJITU0 MA Inhibitor DMJITU0 RN Deciphering the mechanism of carbonic anhydrase inhibition with coumarins and thiocoumarins. J Med Chem. 2010 Jan 14;53(1):335-44. DMJITU0 RU https://pubmed.ncbi.nlm.nih.gov/19911821 DME5WZQ DI DME5WZQ DME5WZQ DN 7-methoxy-2-p-tolyl-4H-chromen-4-one DME5WZQ MI TTGP7BY DME5WZQ MN Monoamine oxidase type B (MAO-B) DME5WZQ MT DTT DME5WZQ MA Inhibitor DME5WZQ RN A new series of flavones, thioflavones, and flavanones as selective monoamine oxidase-B inhibitors. Bioorg Med Chem. 2010 Feb;18(3):1273-9. DME5WZQ RU https://pubmed.ncbi.nlm.nih.gov/20045650 DM4WMGK DI DM4WMGK DM4WMGK DN 7-methoxy-2-p-tolyl-4H-chromene-4-thione DM4WMGK MI TTGP7BY DM4WMGK MN Monoamine oxidase type B (MAO-B) DM4WMGK MT DTT DM4WMGK MA Inhibitor DM4WMGK RN A new series of flavones, thioflavones, and flavanones as selective monoamine oxidase-B inhibitors. Bioorg Med Chem. 2010 Feb;18(3):1273-9. DM4WMGK RU https://pubmed.ncbi.nlm.nih.gov/20045650 DMUZIDT DI DMUZIDT DMUZIDT DN 7-Methoxy-3-pyridin-4-yl-quinoline DMUZIDT MI TT8FYO9 DMUZIDT MN Platelet-derived growth factor receptor alpha (PDGFRA) DMUZIDT MT DTT DMUZIDT MA Inhibitor DMUZIDT RN 5,7-Dimethoxy-3-(4-pyridinyl)quinoline is a potent and selective inhibitor of human vascular beta-type platelet-derived growth factor receptor tyro... J Med Chem. 1994 Aug 19;37(17):2627-9. DMUZIDT RU https://pubmed.ncbi.nlm.nih.gov/8064792 DMUZIDT DI DMUZIDT DMUZIDT DN 7-Methoxy-3-pyridin-4-yl-quinoline DMUZIDT MI TTI7421 DMUZIDT MN Platelet-derived growth factor receptor beta (PDGFRB) DMUZIDT MT DTT DMUZIDT MA Inhibitor DMUZIDT RN 5,7-Dimethoxy-3-(4-pyridinyl)quinoline is a potent and selective inhibitor of human vascular beta-type platelet-derived growth factor receptor tyro... J Med Chem. 1994 Aug 19;37(17):2627-9. DMUZIDT RU https://pubmed.ncbi.nlm.nih.gov/8064792 DM9QKLC DI DM9QKLC DM9QKLC DN 7-Methoxy-3-thiophen-3-yl-quinoline DM9QKLC MI TT8FYO9 DM9QKLC MN Platelet-derived growth factor receptor alpha (PDGFRA) DM9QKLC MT DTT DM9QKLC MA Inhibitor DM9QKLC RN A new series of PDGF receptor tyrosine kinase inhibitors: 3-substituted quinoline derivatives. J Med Chem. 1994 Jul 8;37(14):2129-37. DM9QKLC RU https://pubmed.ncbi.nlm.nih.gov/8035419 DM9QKLC DI DM9QKLC DM9QKLC DN 7-Methoxy-3-thiophen-3-yl-quinoline DM9QKLC MI TTI7421 DM9QKLC MN Platelet-derived growth factor receptor beta (PDGFRB) DM9QKLC MT DTT DM9QKLC MA Inhibitor DM9QKLC RN A new series of PDGF receptor tyrosine kinase inhibitors: 3-substituted quinoline derivatives. J Med Chem. 1994 Jul 8;37(14):2129-37. DM9QKLC RU https://pubmed.ncbi.nlm.nih.gov/8035419 DMNFIZD DI DMNFIZD DMNFIZD DN 7-Methoxy-4-morpholin-4-yl-chromen-2-one DMNFIZD MI TTK3PY9 DMNFIZD MN DNA-dependent protein kinase catalytic (PRKDC) DMNFIZD MT DTT DMNFIZD MA Inhibitor DMNFIZD RN Selective benzopyranone and pyrimido[2,1-a]isoquinolin-4-one inhibitors of DNA-dependent protein kinase: synthesis, structure-activity studies, and... J Med Chem. 2005 Jan 27;48(2):569-85. DMNFIZD RU https://pubmed.ncbi.nlm.nih.gov/15658870 DMH0UVE DI DMH0UVE DMH0UVE DN 7-methoxy-8-propionyl-2H-chromen-2-one DMH0UVE MI TT2LVK8 DMH0UVE MN Carbonic anhydrase IX (CA-IX) DMH0UVE MT DTT DMH0UVE MA Inhibitor DMH0UVE RN 7,8-disubstituted- but not 6,7-disubstituted coumarins selectively inhibit the transmembrane, tumor-associated carbonic anhydrase isoforms IX and X... Bioorg Med Chem Lett. 2010 Dec 15;20(24):7255-8. DMH0UVE RU https://pubmed.ncbi.nlm.nih.gov/21067924 DMHKMU1 DI DMHKMU1 DMHKMU1 DN 7-Methoxy-9H-beta-carboline DMHKMU1 MI TT3WG5C DMHKMU1 MN Monoamine oxidase type A (MAO-A) DMHKMU1 MT DTT DMHKMU1 MA Inhibitor DMHKMU1 RN Binding of beta-carbolines at imidazoline I2 receptors: a structure-affinity investigation. Bioorg Med Chem Lett. 2004 Feb 23;14(4):999-1002. DMHKMU1 RU https://pubmed.ncbi.nlm.nih.gov/15013009 DMHKMU1 DI DMHKMU1 DMHKMU1 DN 7-Methoxy-9H-beta-carboline DMHKMU1 MI TTGP7BY DMHKMU1 MN Monoamine oxidase type B (MAO-B) DMHKMU1 MT DTT DMHKMU1 MA Inhibitor DMHKMU1 RN Binding of beta-carbolines at imidazoline I2 receptors: a structure-affinity investigation. Bioorg Med Chem Lett. 2004 Feb 23;14(4):999-1002. DMHKMU1 RU https://pubmed.ncbi.nlm.nih.gov/15013009 DMUCJA6 DI DMUCJA6 DMUCJA6 DN 7-Methyl-[1,4]thiazepan-(5E)-ylideneamine DMUCJA6 MI TTZUFI5 DMUCJA6 MN Nitric-oxide synthase brain (NOS1) DMUCJA6 MT DTT DMUCJA6 MA Inhibitor DMUCJA6 RN Synthesis of analogs of (1,4)-3- and 5-imino oxazepane, thiazepane, and diazepane as inhibitors of nitric oxide synthases. Bioorg Med Chem Lett. 2004 Dec 6;14(23):5907-11. DMUCJA6 RU https://pubmed.ncbi.nlm.nih.gov/15501067 DMUCJA6 DI DMUCJA6 DMUCJA6 DN 7-Methyl-[1,4]thiazepan-(5E)-ylideneamine DMUCJA6 MI TTCM4B3 DMUCJA6 MN Nitric-oxide synthase endothelial (NOS3) DMUCJA6 MT DTT DMUCJA6 MA Inhibitor DMUCJA6 RN Synthesis of analogs of (1,4)-3- and 5-imino oxazepane, thiazepane, and diazepane as inhibitors of nitric oxide synthases. Bioorg Med Chem Lett. 2004 Dec 6;14(23):5907-11. DMUCJA6 RU https://pubmed.ncbi.nlm.nih.gov/15501067 DMUCJA6 DI DMUCJA6 DMUCJA6 DN 7-Methyl-[1,4]thiazepan-(5E)-ylideneamine DMUCJA6 MI TTF10I9 DMUCJA6 MN Nitric-oxide synthase inducible (NOS2) DMUCJA6 MT DTT DMUCJA6 MA Inhibitor DMUCJA6 RN Synthesis of analogs of (1,4)-3- and 5-imino oxazepane, thiazepane, and diazepane as inhibitors of nitric oxide synthases. Bioorg Med Chem Lett. 2004 Dec 6;14(23):5907-11. DMUCJA6 RU https://pubmed.ncbi.nlm.nih.gov/15501067 DM5EQJU DI DM5EQJU DM5EQJU DN 7-Methyl-1,3-dihydro-imidazo[4,5-b]quinolin-2-one DM5EQJU MI TT06AWU DM5EQJU MN Phosphodiesterase 3A (PDE3A) DM5EQJU MT DTT DM5EQJU MA Inhibitor DM5EQJU RN 1,3-Dihydro-2H-imidazo[4,5-b]quinolin-2-ones--inhibitors of blood platelet cAMP phosphodiesterase and induced aggregation. J Med Chem. 1991 Sep;34(9):2906-16. DM5EQJU RU https://pubmed.ncbi.nlm.nih.gov/1654430 DM7LGDC DI DM7LGDC DM7LGDC DN 7-Methyl-2-m-tolyl-1H-[1,8]naphthyridin-4-one DM7LGDC MI TTML2WA DM7LGDC MN Tubulin (TUB) DM7LGDC MT DTT DM7LGDC MA Inhibitor DM7LGDC RN Antitumor agents. 178. Synthesis and biological evaluation of substituted 2-aryl-1,8-naphthyridin-4(1H)-ones as antitumor agents that inhibit tubul... J Med Chem. 1997 Sep 12;40(19):3049-56. DM7LGDC RU https://pubmed.ncbi.nlm.nih.gov/9301667 DM7LGDC DI DM7LGDC DM7LGDC DN 7-Methyl-2-m-tolyl-1H-[1,8]naphthyridin-4-one DM7LGDC MI TTYFKSZ DM7LGDC MN Tubulin beta (TUBB) DM7LGDC MT DTT DM7LGDC MA Inhibitor DM7LGDC RN Antitumor agents. 178. Synthesis and biological evaluation of substituted 2-aryl-1,8-naphthyridin-4(1H)-ones as antitumor agents that inhibit tubul... J Med Chem. 1997 Sep 12;40(19):3049-56. DM7LGDC RU https://pubmed.ncbi.nlm.nih.gov/9301667 DMCV891 DI DMCV891 DMCV891 DN 7-methyl-2-m-tolylpyrido[2,3-d]pyrimidine DMCV891 MI TTHS256 DMCV891 MN Metabotropic glutamate receptor 5 (mGluR5) DMCV891 MT DTT DMCV891 MA Inhibitor DMCV891 RN Synthesis and SAR of 2-aryl pyrido[2,3-d]pyrimidines as potent mGlu5 receptor antagonists. Bioorg Med Chem Lett. 2007 Oct 1;17(19):5396-9. DMCV891 RU https://pubmed.ncbi.nlm.nih.gov/17723296 DMJ4G27 DI DMJ4G27 DMJ4G27 DN 7-methyl-2-phenylpyrido[2,3-d]pyrimidine DMJ4G27 MI TTHS256 DMJ4G27 MN Metabotropic glutamate receptor 5 (mGluR5) DMJ4G27 MT DTT DMJ4G27 MA Inhibitor DMJ4G27 RN Synthesis and SAR of 2-aryl pyrido[2,3-d]pyrimidines as potent mGlu5 receptor antagonists. Bioorg Med Chem Lett. 2007 Oct 1;17(19):5396-9. DMJ4G27 RU https://pubmed.ncbi.nlm.nih.gov/17723296 DMGB9IE DI DMGB9IE DMGB9IE DN 7-Methyl-2-propyl-[1,8]naphthyridin-4-ol DMGB9IE MI TTK25J1 DMGB9IE MN Adenosine A1 receptor (ADORA1) DMGB9IE MT DTT DMGB9IE MA Inhibitor DMGB9IE RN Study on affinity profile toward native human and bovine adenosine receptors of a series of 1,8-naphthyridine derivatives. J Med Chem. 2004 Jun 3;47(12):3019-31. DMGB9IE RU https://pubmed.ncbi.nlm.nih.gov/15163184 DMB9YA8 DI DMB9YA8 DMB9YA8 DN 7-methyl-2-p-tolyl-4H-chromene-4-thione DMB9YA8 MI TTGP7BY DMB9YA8 MN Monoamine oxidase type B (MAO-B) DMB9YA8 MT DTT DMB9YA8 MA Inhibitor DMB9YA8 RN A new series of flavones, thioflavones, and flavanones as selective monoamine oxidase-B inhibitors. Bioorg Med Chem. 2010 Feb;18(3):1273-9. DMB9YA8 RU https://pubmed.ncbi.nlm.nih.gov/20045650 DMZKO14 DI DMZKO14 DMZKO14 DN 7-Methyl-7H-pyrrolo[3,2-f]quinazoline-1,3-diamine DMZKO14 MI TT9SL3Q DMZKO14 MN Polypeptide deformylase (PDF) DMZKO14 MT DTT DMZKO14 MA Inhibitor DMZKO14 RN High-affinity inhibitors of dihydrofolate reductase: antimicrobial and anticancer activities of 7,8-dialkyl-1,3-diaminopyrrolo[3,2-f]quinazolines w... J Med Chem. 1996 Feb 16;39(4):892-903. DMZKO14 RU https://pubmed.ncbi.nlm.nih.gov/8632413 DMMENDC DI DMMENDC DMMENDC DN 7-METHYL-8-OXO-5-P-TOLYL-7,8-DIHYDRO-[1,7]NAPHTHYRIDINE-6-CARBOXYLIC ACID (3,5-BIS-TRIFLUOROMETHYL-BENZYL)-METHYL-AMIDE (STRUCTURAL MIX) DMMENDC MI TTZPO1L DMMENDC MN Substance-P receptor (TACR1) DMMENDC MT DTT DMMENDC MA Inhibitor DMMENDC RN Axially chiral N-benzyl-N,7-dimethyl-5-phenyl-1, 7-naphthyridine-6-carboxamide derivatives as tachykinin NK1 receptor antagonists: determination of... J Med Chem. 1998 Oct 22;41(22):4232-9. DMMENDC RU https://pubmed.ncbi.nlm.nih.gov/9784098 DMO0RGL DI DMO0RGL DMO0RGL DN 7-METHYL-8-OXO-5-P-TOLYL-7,8-DIHYDRO-[1,7]NAPHTHYRIDINE-6-CARBOXYLIC ACID (S)-[(R)-1-(3,5-BIS-TRIFLUOROMETHYL-PHENYL)-ETHYL]-METHYL-AMIDE (ENANTIOMERIC MIX) DMO0RGL MI TTZPO1L DMO0RGL MN Substance-P receptor (TACR1) DMO0RGL MT DTT DMO0RGL MA Inhibitor DMO0RGL RN Axially chiral N-benzyl-N,7-dimethyl-5-phenyl-1, 7-naphthyridine-6-carboxamide derivatives as tachykinin NK1 receptor antagonists: determination of... J Med Chem. 1998 Oct 22;41(22):4232-9. DMO0RGL RU https://pubmed.ncbi.nlm.nih.gov/9784098 DMOAJ0E DI DMOAJ0E DMOAJ0E DN 7-METHYL-8-OXO-5-P-TOLYL-7,8-DIHYDRO-[1,7]NAPHTHYRIDINE-6-CARBOXYLIC ACID (S)-[(S)-1-(3,5-BIS-TRIFLUOROMETHYL-PHENYL)-ETHYL]-METHYL-AMIDE (ENANTIOMERIC MIX) DMOAJ0E MI TTZPO1L DMOAJ0E MN Substance-P receptor (TACR1) DMOAJ0E MT DTT DMOAJ0E MA Inhibitor DMOAJ0E RN Axially chiral N-benzyl-N,7-dimethyl-5-phenyl-1, 7-naphthyridine-6-carboxamide derivatives as tachykinin NK1 receptor antagonists: determination of... J Med Chem. 1998 Oct 22;41(22):4232-9. DMOAJ0E RU https://pubmed.ncbi.nlm.nih.gov/9784098 DME39U2 DI DME39U2 DME39U2 DN 7-Methyl-Gpppa DME39U2 MI TTZGCP6 DME39U2 MN EIF4E messenger RNA (EIF4E mRNA) DME39U2 MT DTT DME39U2 MA Inhibitor DME39U2 RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DME39U2 RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMCGNUO DI DMCGNUO DMCGNUO DN 7-Methyl-Guanosine-5'-Triphosphate DMCGNUO MI TTZGCP6 DMCGNUO MN EIF4E messenger RNA (EIF4E mRNA) DMCGNUO MT DTT DMCGNUO MA Inhibitor DMCGNUO RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMCGNUO RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMBDFP2 DI DMBDFP2 DMBDFP2 DN 7-m-tolyl-1,6-naphthyridine DMBDFP2 MI TTHS256 DMBDFP2 MN Metabotropic glutamate receptor 5 (mGluR5) DMBDFP2 MT DTT DMBDFP2 MA Inhibitor DMBDFP2 RN Synthesis and SAR comparison of regioisomeric aryl naphthyridines as potent mGlu5 receptor antagonists. Bioorg Med Chem Lett. 2007 Dec 1;17(23):6525-8. DMBDFP2 RU https://pubmed.ncbi.nlm.nih.gov/17936624 DMX3UV1 DI DMX3UV1 DMX3UV1 DN 7-Nitro-1,2,3,4-tetrahydro-isoquinoline DMX3UV1 MI TTWG9A4 DMX3UV1 MN Adrenergic receptor alpha-2A (ADRA2A) DMX3UV1 MT DTT DMX3UV1 MA Inhibitor DMX3UV1 RN Exploring the active site of phenylethanolamine N-methyltransferase with 3-hydroxyethyl- and 3-hydroxypropyl-7-substituted-1,2,3,4-tetrahydroisoqui... Bioorg Med Chem Lett. 2005 Feb 15;15(4):1143-7. DMX3UV1 RU https://pubmed.ncbi.nlm.nih.gov/15686930 DMW4XKQ DI DMW4XKQ DMW4XKQ DN 7-nitro-1H-indazole DMW4XKQ MI TTZUFI5 DMW4XKQ MN Nitric-oxide synthase brain (NOS1) DMW4XKQ MT DTT DMW4XKQ MA Inhibitor DMW4XKQ RN Fluorinated indazoles as novel selective inhibitors of nitric oxide synthase (NOS): synthesis and biological evaluation. Bioorg Med Chem. 2009 Sep 1;17(17):6180-7. DMW4XKQ RU https://pubmed.ncbi.nlm.nih.gov/19679481 DMW4XKQ DI DMW4XKQ DMW4XKQ DN 7-nitro-1H-indazole DMW4XKQ MI TTCM4B3 DMW4XKQ MN Nitric-oxide synthase endothelial (NOS3) DMW4XKQ MT DTT DMW4XKQ MA Inhibitor DMW4XKQ RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMW4XKQ RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMW4XKQ DI DMW4XKQ DMW4XKQ DN 7-nitro-1H-indazole DMW4XKQ MI TTF10I9 DMW4XKQ MN Nitric-oxide synthase inducible (NOS2) DMW4XKQ MT DTT DMW4XKQ MA Inhibitor DMW4XKQ RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMW4XKQ RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMGLWOM DI DMGLWOM DMGLWOM DN 7-Nitroindazole-2-Carboxamidine DMGLWOM MI TTCM4B3 DMGLWOM MN Nitric-oxide synthase endothelial (NOS3) DMGLWOM MT DTT DMGLWOM MA Inhibitor DMGLWOM RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DMGLWOM RU https://pubmed.ncbi.nlm.nih.gov/10592235 DM2403T DI DM2403T DM2403T DN 7n-Methyl-8-Hydroguanosine-5'-Diphosphate DM2403T MI TTZGCP6 DM2403T MN EIF4E messenger RNA (EIF4E mRNA) DM2403T MT DTT DM2403T MA Inhibitor DM2403T RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DM2403T RU https://pubmed.ncbi.nlm.nih.gov/17139284 DM8IY3D DI DM8IY3D DM8IY3D DN 7-O-b-D-Glucopyranosyl-a-homonojirimycin DM8IY3D MI TTLPC70 DM8IY3D MN Lysosomal alpha-glucosidase (GAA) DM8IY3D MT DTT DM8IY3D MA Inhibitor DM8IY3D RN In vitro inhibition of glycogen-degrading enzymes and glycosidases by six-membered sugar mimics and their evaluation in cell cultures. Bioorg Med Chem. 2008 Aug 1;16(15):7330-6. DM8IY3D RU https://pubmed.ncbi.nlm.nih.gov/18595718 DMJZR0A DI DMJZR0A DMJZR0A DN 7-Oxo-7H-dibenzo[de,g]quinoline DMJZR0A MI TT1RS9F DMJZR0A MN Acetylcholinesterase (AChE) DMJZR0A MT DTT DMJZR0A MA Inhibitor DMJZR0A RN Synthesis, biological evaluation and molecular modeling of oxoisoaporphine and oxoaporphine derivatives as new dual inhibitors of acetylcholinester... Eur J Med Chem. 2009 Jun;44(6):2523-32. DMJZR0A RU https://pubmed.ncbi.nlm.nih.gov/19243862 DMJZR0A DI DMJZR0A DMJZR0A DN 7-Oxo-7H-dibenzo[de,g]quinoline DMJZR0A MI TTEB0GD DMJZR0A MN Cholinesterase (BCHE) DMJZR0A MT DTT DMJZR0A MA Inhibitor DMJZR0A RN Synthesis, biological evaluation and molecular modeling of oxoisoaporphine and oxoaporphine derivatives as new dual inhibitors of acetylcholinester... Eur J Med Chem. 2009 Jun;44(6):2523-32. DMJZR0A RU https://pubmed.ncbi.nlm.nih.gov/19243862 DM8Q267 DI DM8Q267 DM8Q267 DN 7-phenethoxy-2H-chromen-2-one DM8Q267 MI TTUNARX DM8Q267 MN Carbonic anhydrase (CA) DM8Q267 MT DTT DM8Q267 MA Inhibitor DM8Q267 RN Deciphering the mechanism of carbonic anhydrase inhibition with coumarins and thiocoumarins. J Med Chem. 2010 Jan 14;53(1):335-44. DM8Q267 RU https://pubmed.ncbi.nlm.nih.gov/19911821 DM8Q267 DI DM8Q267 DM8Q267 DN 7-phenethoxy-2H-chromen-2-one DM8Q267 MI TT2LVK8 DM8Q267 MN Carbonic anhydrase IX (CA-IX) DM8Q267 MT DTT DM8Q267 MA Inhibitor DM8Q267 RN Deciphering the mechanism of carbonic anhydrase inhibition with coumarins and thiocoumarins. J Med Chem. 2010 Jan 14;53(1):335-44. DM8Q267 RU https://pubmed.ncbi.nlm.nih.gov/19911821 DM8Q267 DI DM8Q267 DM8Q267 DN 7-phenethoxy-2H-chromen-2-one DM8Q267 MI TTSYM0R DM8Q267 MN Carbonic anhydrase XII (CA-XII) DM8Q267 MT DTT DM8Q267 MA Inhibitor DM8Q267 RN Deciphering the mechanism of carbonic anhydrase inhibition with coumarins and thiocoumarins. J Med Chem. 2010 Jan 14;53(1):335-44. DM8Q267 RU https://pubmed.ncbi.nlm.nih.gov/19911821 DM8Q267 DI DM8Q267 DM8Q267 DN 7-phenethoxy-2H-chromen-2-one DM8Q267 MI TTEYTKG DM8Q267 MN Carbonic anhydrase XIV (CA-XIV) DM8Q267 MT DTT DM8Q267 MA Inhibitor DM8Q267 RN Deciphering the mechanism of carbonic anhydrase inhibition with coumarins and thiocoumarins. J Med Chem. 2010 Jan 14;53(1):335-44. DM8Q267 RU https://pubmed.ncbi.nlm.nih.gov/19911821 DM1FL5G DI DM1FL5G DM1FL5G DN 7-Phenoxy-heptanoic acid hydroxyamide DM1FL5G MI TT6R7JZ DM1FL5G MN Histone deacetylase 1 (HDAC1) DM1FL5G MT DTT DM1FL5G MA Inhibitor DM1FL5G RN A novel series of histone deacetylase inhibitors incorporating hetero aromatic ring systems as connection units. Bioorg Med Chem Lett. 2003 Nov 3;13(21):3817-20. DM1FL5G RU https://pubmed.ncbi.nlm.nih.gov/14552787 DM1FL5G DI DM1FL5G DM1FL5G DN 7-Phenoxy-heptanoic acid hydroxyamide DM1FL5G MI TTSHTOI DM1FL5G MN Histone deacetylase 2 (HDAC2) DM1FL5G MT DTT DM1FL5G MA Inhibitor DM1FL5G RN A novel series of histone deacetylase inhibitors incorporating hetero aromatic ring systems as connection units. Bioorg Med Chem Lett. 2003 Nov 3;13(21):3817-20. DM1FL5G RU https://pubmed.ncbi.nlm.nih.gov/14552787 DMQMRGD DI DMQMRGD DMQMRGD DN 7-Phenyl-1-(1,3,4-thiadiazol-2-yl)-heptan-1-one DMQMRGD MI TTDP1UC DMQMRGD MN Fatty acid amide hydrolase (FAAH) DMQMRGD MT DTT DMQMRGD MA Inhibitor DMQMRGD RN Optimization of the central heterocycle of alpha-ketoheterocycle inhibitors of fatty acid amide hydrolase. J Med Chem. 2008 Aug 14;51(15):4392-403. DMQMRGD RU https://pubmed.ncbi.nlm.nih.gov/18630870 DMEABGI DI DMEABGI DMEABGI DN 7-Phenyl-1-(2H-tetrazol-5-yl)-heptan-1-one DMEABGI MI TTDP1UC DMEABGI MN Fatty acid amide hydrolase (FAAH) DMEABGI MT DTT DMEABGI MA Inhibitor DMEABGI RN Optimization of the central heterocycle of alpha-ketoheterocycle inhibitors of fatty acid amide hydrolase. J Med Chem. 2008 Aug 14;51(15):4392-403. DMEABGI RU https://pubmed.ncbi.nlm.nih.gov/18630870 DM62PAU DI DM62PAU DM62PAU DN 7-phenyl-1-(4-phenyloxazol-2-yl)heptan-1-one DM62PAU MI TTDP1UC DM62PAU MN Fatty acid amide hydrolase (FAAH) DM62PAU MT DTT DM62PAU MA Inhibitor DM62PAU RN Exploration of a fundamental substituent effect of alpha-ketoheterocycle enzyme inhibitors: Potent and selective inhibitors of fatty acid amide hyd... Bioorg Med Chem Lett. 2008 Nov 15;18(22):5842-6. DM62PAU RU https://pubmed.ncbi.nlm.nih.gov/18639454 DM9SGBW DI DM9SGBW DM9SGBW DN 7-phenyl-1-(5-phenyloxazol-2-yl)heptan-1-one DM9SGBW MI TTDP1UC DM9SGBW MN Fatty acid amide hydrolase (FAAH) DM9SGBW MT DTT DM9SGBW MA Inhibitor DM9SGBW RN Optimization of the central heterocycle of alpha-ketoheterocycle inhibitors of fatty acid amide hydrolase. J Med Chem. 2008 Aug 14;51(15):4392-403. DM9SGBW RU https://pubmed.ncbi.nlm.nih.gov/18630870 DMG1PNX DI DMG1PNX DMG1PNX DN 7-Phenyl-1-(pyridazin-3-yl)-heptan-1-one DMG1PNX MI TTDP1UC DMG1PNX MN Fatty acid amide hydrolase (FAAH) DMG1PNX MT DTT DMG1PNX MA Inhibitor DMG1PNX RN Optimization of the central heterocycle of alpha-ketoheterocycle inhibitors of fatty acid amide hydrolase. J Med Chem. 2008 Aug 14;51(15):4392-403. DMG1PNX RU https://pubmed.ncbi.nlm.nih.gov/18630870 DMLHI5T DI DMLHI5T DMLHI5T DN 7-Phenyl-1-(thiazol-2-yl)-heptan-1-one DMLHI5T MI TTDP1UC DMLHI5T MN Fatty acid amide hydrolase (FAAH) DMLHI5T MT DTT DMLHI5T MA Inhibitor DMLHI5T RN Optimization of the central heterocycle of alpha-ketoheterocycle inhibitors of fatty acid amide hydrolase. J Med Chem. 2008 Aug 14;51(15):4392-403. DMLHI5T RU https://pubmed.ncbi.nlm.nih.gov/18630870 DMEDOFB DI DMEDOFB DMEDOFB DN 7-phenylethoxy-2-morpholin-4-yl-chromen-4-one DMEDOFB MI TTK3PY9 DMEDOFB MN DNA-dependent protein kinase catalytic (PRKDC) DMEDOFB MT DTT DMEDOFB MA Inhibitor DMEDOFB RN Discovery of potent chromen-4-one inhibitors of the DNA-dependent protein kinase (DNA-PK) using a small-molecule library approach. J Med Chem. 2005 Dec 1;48(24):7829-46. DMEDOFB RU https://pubmed.ncbi.nlm.nih.gov/16302822 DM1WJFR DI DM1WJFR DM1WJFR DN 7-Phenyl-naphthalen-2-ol DM1WJFR MI TTZAYWL DM1WJFR MN Estrogen receptor (ESR) DM1WJFR MT DTT DM1WJFR MA Inhibitor DM1WJFR RN ERbeta ligands. 3. Exploiting two binding orientations of the 2-phenylnaphthalene scaffold to achieve ERbeta selectivity. J Med Chem. 2005 Jun 16;48(12):3953-79. DM1WJFR RU https://pubmed.ncbi.nlm.nih.gov/15943471 DM1WJFR DI DM1WJFR DM1WJFR DN 7-Phenyl-naphthalen-2-ol DM1WJFR MI TTOM3J0 DM1WJFR MN Estrogen receptor beta (ESR2) DM1WJFR MT DTT DM1WJFR MA Inhibitor DM1WJFR RN ERbeta ligands. 3. Exploiting two binding orientations of the 2-phenylnaphthalene scaffold to achieve ERbeta selectivity. J Med Chem. 2005 Jun 16;48(12):3953-79. DM1WJFR RU https://pubmed.ncbi.nlm.nih.gov/15943471 DMSBJ4M DI DMSBJ4M DMSBJ4M DN 7-phenyloxyethoxy-2-morpholin-4-yl-chromen-4-one DMSBJ4M MI TTK3PY9 DMSBJ4M MN DNA-dependent protein kinase catalytic (PRKDC) DMSBJ4M MT DTT DMSBJ4M MA Inhibitor DMSBJ4M RN Discovery of potent chromen-4-one inhibitors of the DNA-dependent protein kinase (DNA-PK) using a small-molecule library approach. J Med Chem. 2005 Dec 1;48(24):7829-46. DMSBJ4M RU https://pubmed.ncbi.nlm.nih.gov/16302822 DM19I62 DI DM19I62 DM19I62 DN 7-Phloroethol DM19I62 MI TT8JRS7 DM19I62 MN Beta-secretase (BACE) DM19I62 MT DTT DM19I62 MA Inhibitor DM19I62 RN Molecular docking studies of phlorotannins from Eisenia bicyclis with BACE1 inhibitory activity. Bioorg Med Chem Lett. 2010 Jun 1;20(11):3211-5. DM19I62 RU https://pubmed.ncbi.nlm.nih.gov/20462757 DMO8WB2 DI DMO8WB2 DMO8WB2 DN 7-propoxy-2-(morpholin-4-yl)-chromen-4-one DMO8WB2 MI TTK3PY9 DMO8WB2 MN DNA-dependent protein kinase catalytic (PRKDC) DMO8WB2 MT DTT DMO8WB2 MA Inhibitor DMO8WB2 RN Discovery of potent chromen-4-one inhibitors of the DNA-dependent protein kinase (DNA-PK) using a small-molecule library approach. J Med Chem. 2005 Dec 1;48(24):7829-46. DMO8WB2 RU https://pubmed.ncbi.nlm.nih.gov/16302822 DMD5CB6 DI DMD5CB6 DMD5CB6 DN 7-propoxy-2H-chromen-2-one DMD5CB6 MI TTUNARX DMD5CB6 MN Carbonic anhydrase (CA) DMD5CB6 MT DTT DMD5CB6 MA Inhibitor DMD5CB6 RN Deciphering the mechanism of carbonic anhydrase inhibition with coumarins and thiocoumarins. J Med Chem. 2010 Jan 14;53(1):335-44. DMD5CB6 RU https://pubmed.ncbi.nlm.nih.gov/19911821 DMD5CB6 DI DMD5CB6 DMD5CB6 DN 7-propoxy-2H-chromen-2-one DMD5CB6 MI TT2LVK8 DMD5CB6 MN Carbonic anhydrase IX (CA-IX) DMD5CB6 MT DTT DMD5CB6 MA Inhibitor DMD5CB6 RN Deciphering the mechanism of carbonic anhydrase inhibition with coumarins and thiocoumarins. J Med Chem. 2010 Jan 14;53(1):335-44. DMD5CB6 RU https://pubmed.ncbi.nlm.nih.gov/19911821 DMD5CB6 DI DMD5CB6 DMD5CB6 DN 7-propoxy-2H-chromen-2-one DMD5CB6 MI TTCFSPE DMD5CB6 MN Carbonic anhydrase VI (CA-VI) DMD5CB6 MT DTT DMD5CB6 MA Inhibitor DMD5CB6 RN Deciphering the mechanism of carbonic anhydrase inhibition with coumarins and thiocoumarins. J Med Chem. 2010 Jan 14;53(1):335-44. DMD5CB6 RU https://pubmed.ncbi.nlm.nih.gov/19911821 DMD5CB6 DI DMD5CB6 DMD5CB6 DN 7-propoxy-2H-chromen-2-one DMD5CB6 MI TTSYM0R DMD5CB6 MN Carbonic anhydrase XII (CA-XII) DMD5CB6 MT DTT DMD5CB6 MA Inhibitor DMD5CB6 RN Deciphering the mechanism of carbonic anhydrase inhibition with coumarins and thiocoumarins. J Med Chem. 2010 Jan 14;53(1):335-44. DMD5CB6 RU https://pubmed.ncbi.nlm.nih.gov/19911821 DMD5CB6 DI DMD5CB6 DMD5CB6 DN 7-propoxy-2H-chromen-2-one DMD5CB6 MI TTEYTKG DMD5CB6 MN Carbonic anhydrase XIV (CA-XIV) DMD5CB6 MT DTT DMD5CB6 MA Inhibitor DMD5CB6 RN Deciphering the mechanism of carbonic anhydrase inhibition with coumarins and thiocoumarins. J Med Chem. 2010 Jan 14;53(1):335-44. DMD5CB6 RU https://pubmed.ncbi.nlm.nih.gov/19911821 DM4I0B1 DI DM4I0B1 DM4I0B1 DN 7-Propyl-7H-adenine DM4I0B1 MI TTM2AOE DM4I0B1 MN Adenosine A2a receptor (ADORA2A) DM4I0B1 MT DTT DM4I0B1 MA Inhibitor DM4I0B1 RN 8-Bromo-9-alkyl adenine derivatives as tools for developing new adenosine A2A and A2B receptors ligands. Bioorg Med Chem. 2009 Apr 1;17(7):2812-22. DM4I0B1 RU https://pubmed.ncbi.nlm.nih.gov/19282184 DMW8XME DI DMW8XME DMW8XME DN 7-Pyridin-3-yl-2H-1,4-benzothiazin-3(4H)-one DMW8XME MI TTIQUX7 DMW8XME MN Steroid 11-beta-hydroxylase (CYP11B1) DMW8XME MT DTT DMW8XME MA Inhibitor DMW8XME RN In vivo active aldosterone synthase inhibitors with improved selectivity: lead optimization providing a series of pyridine substituted 3,4-dihydro-... J Med Chem. 2008 Dec 25;51(24):8077-87. DMW8XME RU https://pubmed.ncbi.nlm.nih.gov/19049427 DMQJ26K DI DMQJ26K DMQJ26K DN 7-Pyrrolidin-1-yl-hept-5-yn-2-one DMQJ26K MI TTZ9SOR DMQJ26K MN Muscarinic acetylcholine receptor M1 (CHRM1) DMQJ26K MT DTT DMQJ26K MA Inhibitor DMQJ26K RN Cholinergic agents: aldehyde, ketone, and oxime analogues of the muscarinic agonist UH5, Bioorg. Med. Chem. Lett. 2(8):803-808 (1992). DMQJ26K RU http://www.sciencedirect.com/science/article/pii/S0960894X00805351 DMQJ26K DI DMQJ26K DMQJ26K DN 7-Pyrrolidin-1-yl-hept-5-yn-2-one DMQJ26K MI TTYEG6Q DMQJ26K MN Muscarinic acetylcholine receptor M2 (CHRM2) DMQJ26K MT DTT DMQJ26K MA Inhibitor DMQJ26K RN Cholinergic agents: aldehyde, ketone, and oxime analogues of the muscarinic agonist UH5, Bioorg. Med. Chem. Lett. 2(8):803-808 (1992). DMQJ26K RU http://www.sciencedirect.com/science/article/pii/S0960894X00805351 DMQJ26K DI DMQJ26K DMQJ26K DN 7-Pyrrolidin-1-yl-hept-5-yn-2-one DMQJ26K MI TTQ13Z5 DMQJ26K MN Muscarinic acetylcholine receptor M3 (CHRM3) DMQJ26K MT DTT DMQJ26K MA Inhibitor DMQJ26K RN Cholinergic agents: aldehyde, ketone, and oxime analogues of the muscarinic agonist UH5, Bioorg. Med. Chem. Lett. 2(8):803-808 (1992). DMQJ26K RU http://www.sciencedirect.com/science/article/pii/S0960894X00805351 DMQJ26K DI DMQJ26K DMQJ26K DN 7-Pyrrolidin-1-yl-hept-5-yn-2-one DMQJ26K MI TTQ3JTF DMQJ26K MN Muscarinic acetylcholine receptor M4 (CHRM4) DMQJ26K MT DTT DMQJ26K MA Inhibitor DMQJ26K RN Cholinergic agents: aldehyde, ketone, and oxime analogues of the muscarinic agonist UH5, Bioorg. Med. Chem. Lett. 2(8):803-808 (1992). DMQJ26K RU http://www.sciencedirect.com/science/article/pii/S0960894X00805351 DMQJ26K DI DMQJ26K DMQJ26K DN 7-Pyrrolidin-1-yl-hept-5-yn-2-one DMQJ26K MI TTH18TF DMQJ26K MN Muscarinic acetylcholine receptor M5 (CHRM5) DMQJ26K MT DTT DMQJ26K MA Inhibitor DMQJ26K RN Cholinergic agents: aldehyde, ketone, and oxime analogues of the muscarinic agonist UH5, Bioorg. Med. Chem. Lett. 2(8):803-808 (1992). DMQJ26K RU http://www.sciencedirect.com/science/article/pii/S0960894X00805351 DMSU06X DI DMSU06X DMSU06X DN 7-tert-butyl-2, 3-dihydro-3, 3-dimethyl substituted dihydrofuran 30 (DHDMBF30) DMSU06X MI TT2J34L DMSU06X MN Arachidonate 5-lipoxygenase (5-LOX) DMSU06X MT DTT DMSU06X MA Inhibitor DMSU06X RN Effect of 5-LOX/COX-2 common inhibitor DHDMBF30 on pancreatic cancer cell Capan2. World J Gastroenterol. 2008 Apr 28;14(16):2494-500. DMSU06X RU https://pubmed.ncbi.nlm.nih.gov/18442195 DMSU06X DI DMSU06X DMSU06X DN 7-tert-butyl-2, 3-dihydro-3, 3-dimethyl substituted dihydrofuran 30 (DHDMBF30) DMSU06X MI TTT1MCF DMSU06X MN Permeability pathway (NP pathway) DMSU06X MT DTT DMSU06X MA Inhibitor DMSU06X RN Novel molecular targets for antimalarial drug development. Chem Biol Drug Des. 2008 Apr;71(4):287-97. DMSU06X RU https://pubmed.ncbi.nlm.nih.gov/18298458 DMSU06X DI DMSU06X DMSU06X DN 7-tert-butyl-2, 3-dihydro-3, 3-dimethyl substituted dihydrofuran 30 (DHDMBF30) DMSU06X MI TTMCF1Y DMSU06X MN Purine nucleoside phosphorylase (PNP) DMSU06X MT DTT DMSU06X MA Inhibitor DMSU06X RN Expression of human malaria parasite purine nucleoside phosphorylase in host enzyme-deficient erythrocyte culture. Enzyme characterization and identification of novel inhibitors. J Biol Chem. 1986 Sep 5;261(25):11667-73. DMSU06X RU https://pubmed.ncbi.nlm.nih.gov/3091593 DMD7Q1R DI DMD7Q1R DMD7Q1R DN 7-tert-butyl-9H-carbazole-3-carboxylic acid DMD7Q1R MI TTBGTCW DMD7Q1R MN Kinesin spindle messenger RNA (KIF11 mRNA) DMD7Q1R MT DTT DMD7Q1R MA Inhibitor DMD7Q1R RN Kinesin spindle protein (KSP) inhibitors with 2,3-fused indole scaffolds. J Med Chem. 2010 Jul 8;53(13):5054-8. DMD7Q1R RU https://pubmed.ncbi.nlm.nih.gov/20521839 DMMU5SO DI DMMU5SO DMMU5SO DN 7-Thiophen-3-yl-[1,3]dioxolo[4,5-g]quinoline DMMU5SO MI TT8FYO9 DMMU5SO MN Platelet-derived growth factor receptor alpha (PDGFRA) DMMU5SO MT DTT DMMU5SO MA Inhibitor DMMU5SO RN A new series of PDGF receptor tyrosine kinase inhibitors: 3-substituted quinoline derivatives. J Med Chem. 1994 Jul 8;37(14):2129-37. DMMU5SO RU https://pubmed.ncbi.nlm.nih.gov/8035419 DMMU5SO DI DMMU5SO DMMU5SO DN 7-Thiophen-3-yl-[1,3]dioxolo[4,5-g]quinoline DMMU5SO MI TTI7421 DMMU5SO MN Platelet-derived growth factor receptor beta (PDGFRB) DMMU5SO MT DTT DMMU5SO MA Inhibitor DMMU5SO RN A new series of PDGF receptor tyrosine kinase inhibitors: 3-substituted quinoline derivatives. J Med Chem. 1994 Jul 8;37(14):2129-37. DMMU5SO RU https://pubmed.ncbi.nlm.nih.gov/8035419 DMOQMA0 DI DMOQMA0 DMOQMA0 DN 7-trans-OH-PIPAT DMOQMA0 MI TTEX248 DMOQMA0 MN Dopamine D2 receptor (D2R) DMOQMA0 MT DTT DMOQMA0 MA Agonist DMOQMA0 RN Iodinated 2-aminotetralins and 3-amino-1-benzopyrans: ligands for dopamine D2 and D3 receptors. J Med Chem. 1994 Nov 25;37(24):4245-50. DMOQMA0 RU https://pubmed.ncbi.nlm.nih.gov/7990123 DMOQMA0 DI DMOQMA0 DMOQMA0 DN 7-trans-OH-PIPAT DMOQMA0 MI TT4C8EA DMOQMA0 MN Dopamine D3 receptor (D3R) DMOQMA0 MT DTT DMOQMA0 MA Agonist DMOQMA0 RN Iodinated 2-aminotetralins and 3-amino-1-benzopyrans: ligands for dopamine D2 and D3 receptors. J Med Chem. 1994 Nov 25;37(24):4245-50. DMOQMA0 RU https://pubmed.ncbi.nlm.nih.gov/7990123 DM14OHR DI DM14OHR DM14OHR DN 7-vinyl-6H-chromeno[4,3-b]quinoline-3,9-diol DM14OHR MI TTPNQAC DM14OHR MN Estrogen-related receptor-alpha (ESRRA) DM14OHR MT DTT DM14OHR MA Inhibitor DM14OHR RN ERbeta ligands. Part 6: 6H-Chromeno[4,3-b]quinolines as a new series of estrogen receptor beta-selective ligands. Bioorg Med Chem Lett. 2007 Jul 15;17(14):4053-6. DM14OHR RU https://pubmed.ncbi.nlm.nih.gov/17482813 DMUE15B DI DMUE15B DMUE15B DN 8-(1,2-Dimethyl-propoxy)-quinolin-2-ylamine DMUE15B MI TTX4RTB DMUE15B MN Melanin-concentrating hormone receptor 1 (MCHR1) DMUE15B MT DTT DMUE15B MA Inhibitor DMUE15B RN Synthesis and evaluation of 2-amino-8-alkoxy quinolines as MCHr1 antagonists. Part 1. Bioorg Med Chem Lett. 2004 Oct 4;14(19):4873-7. DMUE15B RU https://pubmed.ncbi.nlm.nih.gov/15341942 DMGS7CE DI DMGS7CE DMGS7CE DN 8-(1,3,3-Trimethyl-butoxy)-quinolin-2-ylamine DMGS7CE MI TTX4RTB DMGS7CE MN Melanin-concentrating hormone receptor 1 (MCHR1) DMGS7CE MT DTT DMGS7CE MA Inhibitor DMGS7CE RN Synthesis and evaluation of 2-amino-8-alkoxy quinolines as MCHr1 antagonists. Part 2. Bioorg Med Chem Lett. 2004 Oct 4;14(19):4879-82. DMGS7CE RU https://pubmed.ncbi.nlm.nih.gov/15341943 DMYERNW DI DMYERNW DMYERNW DN 8-(1-Ethyl-propoxy)-quinolin-2-ylamine DMYERNW MI TTX4RTB DMYERNW MN Melanin-concentrating hormone receptor 1 (MCHR1) DMYERNW MT DTT DMYERNW MA Inhibitor DMYERNW RN Synthesis and evaluation of 2-amino-8-alkoxy quinolines as MCHr1 antagonists. Part 1. Bioorg Med Chem Lett. 2004 Oct 4;14(19):4873-7. DMYERNW RU https://pubmed.ncbi.nlm.nih.gov/15341942 DMMBH9N DI DMMBH9N DMMBH9N DN 8-(1H-indol-5-yl)-2-morpholin-4-ylchromen-4-one DMMBH9N MI TTK3PY9 DMMBH9N MN DNA-dependent protein kinase catalytic (PRKDC) DMMBH9N MT DTT DMMBH9N MA Inhibitor DMMBH9N RN Discovery of potent chromen-4-one inhibitors of the DNA-dependent protein kinase (DNA-PK) using a small-molecule library approach. J Med Chem. 2005 Dec 1;48(24):7829-46. DMMBH9N RU https://pubmed.ncbi.nlm.nih.gov/16302822 DM7VT3P DI DM7VT3P DM7VT3P DN 8-(1-Methyl-butoxy)-quinolin-2-ylamine DM7VT3P MI TTX4RTB DM7VT3P MN Melanin-concentrating hormone receptor 1 (MCHR1) DM7VT3P MT DTT DM7VT3P MA Inhibitor DM7VT3P RN Synthesis and evaluation of 2-amino-8-alkoxy quinolines as MCHr1 antagonists. Part 1. Bioorg Med Chem Lett. 2004 Oct 4;14(19):4873-7. DM7VT3P RU https://pubmed.ncbi.nlm.nih.gov/15341942 DMV5FZO DI DMV5FZO DMV5FZO DN 8-(2,2-dimethylpropyl)naringenin DMV5FZO MI TTZAYWL DMV5FZO MN Estrogen receptor (ESR) DMV5FZO MT DTT DMV5FZO MA Inhibitor DMV5FZO RN Subtle side-chain modifications of the hop phytoestrogen 8-prenylnaringenin result in distinct agonist/antagonist activity profiles for estrogen re... J Med Chem. 2006 Dec 14;49(25):7357-65. DMV5FZO RU https://pubmed.ncbi.nlm.nih.gov/17149865 DMV5FZO DI DMV5FZO DMV5FZO DN 8-(2,2-dimethylpropyl)naringenin DMV5FZO MI TTOM3J0 DMV5FZO MN Estrogen receptor beta (ESR2) DMV5FZO MT DTT DMV5FZO MA Inhibitor DMV5FZO RN Subtle side-chain modifications of the hop phytoestrogen 8-prenylnaringenin result in distinct agonist/antagonist activity profiles for estrogen re... J Med Chem. 2006 Dec 14;49(25):7357-65. DMV5FZO RU https://pubmed.ncbi.nlm.nih.gov/17149865 DM3QV95 DI DM3QV95 DM3QV95 DN 8-(2,3,4-trimethoxyphenyl)-9H-purine-2,6-diamine DM3QV95 MI TT9SL3Q DM3QV95 MN Polypeptide deformylase (PDF) DM3QV95 MT DTT DM3QV95 MA Inhibitor DM3QV95 RN CoMFA analysis of tgDHFR and rlDHFR based on antifolates with 6-5 fused ring system using the all-orientation search (AOS) routine and a modified c... Bioorg Med Chem. 2010 Feb 15;18(4):1684-701. DM3QV95 RU https://pubmed.ncbi.nlm.nih.gov/20117005 DM4KP5M DI DM4KP5M DM4KP5M DN 8-(2,4,5-trimethoxyphenyl)-9H-purine-2,6-diamine DM4KP5M MI TT9SL3Q DM4KP5M MN Polypeptide deformylase (PDF) DM4KP5M MT DTT DM4KP5M MA Inhibitor DM4KP5M RN CoMFA analysis of tgDHFR and rlDHFR based on antifolates with 6-5 fused ring system using the all-orientation search (AOS) routine and a modified c... Bioorg Med Chem. 2010 Feb 15;18(4):1684-701. DM4KP5M RU https://pubmed.ncbi.nlm.nih.gov/20117005 DM5TSJF DI DM5TSJF DM5TSJF DN 8-(2,4,6-trimethoxyphenyl)-9H-purine-2,6-diamine DM5TSJF MI TT9SL3Q DM5TSJF MN Polypeptide deformylase (PDF) DM5TSJF MT DTT DM5TSJF MA Inhibitor DM5TSJF RN CoMFA analysis of tgDHFR and rlDHFR based on antifolates with 6-5 fused ring system using the all-orientation search (AOS) routine and a modified c... Bioorg Med Chem. 2010 Feb 15;18(4):1684-701. DM5TSJF RU https://pubmed.ncbi.nlm.nih.gov/20117005 DMJPYIZ DI DMJPYIZ DMJPYIZ DN 8-(2,4-dimethoxyphenyl)-9H-purine-2,6-diamine DMJPYIZ MI TT9SL3Q DMJPYIZ MN Polypeptide deformylase (PDF) DMJPYIZ MT DTT DMJPYIZ MA Inhibitor DMJPYIZ RN CoMFA analysis of tgDHFR and rlDHFR based on antifolates with 6-5 fused ring system using the all-orientation search (AOS) routine and a modified c... Bioorg Med Chem. 2010 Feb 15;18(4):1684-701. DMJPYIZ RU https://pubmed.ncbi.nlm.nih.gov/20117005 DM0MIGU DI DM0MIGU DM0MIGU DN 8-(2,5-dimethoxyphenyl)-9H-purine-2,6-diamine DM0MIGU MI TT9SL3Q DM0MIGU MN Polypeptide deformylase (PDF) DM0MIGU MT DTT DM0MIGU MA Inhibitor DM0MIGU RN CoMFA analysis of tgDHFR and rlDHFR based on antifolates with 6-5 fused ring system using the all-orientation search (AOS) routine and a modified c... Bioorg Med Chem. 2010 Feb 15;18(4):1684-701. DM0MIGU RU https://pubmed.ncbi.nlm.nih.gov/20117005 DMECWL1 DI DMECWL1 DMECWL1 DN 8-(2,6-Dichloro-phenyl)-9H-purine-2,6-diamine DMECWL1 MI TT9SL3Q DMECWL1 MN Polypeptide deformylase (PDF) DMECWL1 MT DTT DMECWL1 MA Inhibitor DMECWL1 RN Conformationally restricted analogues of trimethoprim: 2,6-diamino-8-substituted purines as potential dihydrofolate reductase inhibitors from Pneum... J Med Chem. 1997 Sep 12;40(19):3032-9. DMECWL1 RU https://pubmed.ncbi.nlm.nih.gov/9301665 DM8SRM0 DI DM8SRM0 DM8SRM0 DN 8-(2-acetylphenyl)-2-morpholin-4-ylchromen-4-one DM8SRM0 MI TTK3PY9 DM8SRM0 MN DNA-dependent protein kinase catalytic (PRKDC) DM8SRM0 MT DTT DM8SRM0 MA Inhibitor DM8SRM0 RN Discovery of potent chromen-4-one inhibitors of the DNA-dependent protein kinase (DNA-PK) using a small-molecule library approach. J Med Chem. 2005 Dec 1;48(24):7829-46. DM8SRM0 RU https://pubmed.ncbi.nlm.nih.gov/16302822 DMJKL3Z DI DMJKL3Z DMJKL3Z DN 8-(2-Cyclopropyl-ethoxy)-quinolin-2-ylamine DMJKL3Z MI TTX4RTB DMJKL3Z MN Melanin-concentrating hormone receptor 1 (MCHR1) DMJKL3Z MT DTT DMJKL3Z MA Inhibitor DMJKL3Z RN Synthesis and evaluation of 2-amino-8-alkoxy quinolines as MCHr1 antagonists. Part 1. Bioorg Med Chem Lett. 2004 Oct 4;14(19):4873-7. DMJKL3Z RU https://pubmed.ncbi.nlm.nih.gov/15341942 DMOB8XT DI DMOB8XT DMOB8XT DN 8-(2-Ethoxy-1-methyl-ethoxy)-quinolin-2-ylamine DMOB8XT MI TTX4RTB DMOB8XT MN Melanin-concentrating hormone receptor 1 (MCHR1) DMOB8XT MT DTT DMOB8XT MA Inhibitor DMOB8XT RN Synthesis and evaluation of 2-amino-8-alkoxy quinolines as MCHr1 antagonists. Part 1. Bioorg Med Chem Lett. 2004 Oct 4;14(19):4873-7. DMOB8XT RU https://pubmed.ncbi.nlm.nih.gov/15341942 DMSKTVW DI DMSKTVW DMSKTVW DN 8-(2-Ethyl-1-methyl-butoxy)-quinolin-2-ylamine DMSKTVW MI TTX4RTB DMSKTVW MN Melanin-concentrating hormone receptor 1 (MCHR1) DMSKTVW MT DTT DMSKTVW MA Inhibitor DMSKTVW RN Synthesis and evaluation of 2-amino-8-alkoxy quinolines as MCHr1 antagonists. Part 1. Bioorg Med Chem Lett. 2004 Oct 4;14(19):4873-7. DMSKTVW RU https://pubmed.ncbi.nlm.nih.gov/15341942 DMA5K04 DI DMA5K04 DMA5K04 DN 8-(2-Methoxy-1-methyl-ethoxy)-quinolin-2-ylamine DMA5K04 MI TTX4RTB DMA5K04 MN Melanin-concentrating hormone receptor 1 (MCHR1) DMA5K04 MT DTT DMA5K04 MA Inhibitor DMA5K04 RN Synthesis and evaluation of 2-amino-8-alkoxy quinolines as MCHr1 antagonists. Part 1. Bioorg Med Chem Lett. 2004 Oct 4;14(19):4873-7. DMA5K04 RU https://pubmed.ncbi.nlm.nih.gov/15341942 DMVBRMF DI DMVBRMF DMVBRMF DN 8-(2-Methyl-butoxy)-quinolin-2-ylamine DMVBRMF MI TTX4RTB DMVBRMF MN Melanin-concentrating hormone receptor 1 (MCHR1) DMVBRMF MT DTT DMVBRMF MA Inhibitor DMVBRMF RN Synthesis and evaluation of 2-amino-8-alkoxy quinolines as MCHr1 antagonists. Part 1. Bioorg Med Chem Lett. 2004 Oct 4;14(19):4873-7. DMVBRMF RU https://pubmed.ncbi.nlm.nih.gov/15341942 DMUIFJY DI DMUIFJY DMUIFJY DN 8-(2-Methyl-cyclohexyloxy)-quinolin-2-ylamine DMUIFJY MI TTX4RTB DMUIFJY MN Melanin-concentrating hormone receptor 1 (MCHR1) DMUIFJY MT DTT DMUIFJY MA Inhibitor DMUIFJY RN Synthesis and evaluation of 2-amino-8-alkoxy quinolines as MCHr1 antagonists. Part 1. Bioorg Med Chem Lett. 2004 Oct 4;14(19):4873-7. DMUIFJY RU https://pubmed.ncbi.nlm.nih.gov/15341942 DMQUZSJ DI DMQUZSJ DMQUZSJ DN 8-(2-methylpropyl)naringenin DMQUZSJ MI TTZAYWL DMQUZSJ MN Estrogen receptor (ESR) DMQUZSJ MT DTT DMQUZSJ MA Inhibitor DMQUZSJ RN Subtle side-chain modifications of the hop phytoestrogen 8-prenylnaringenin result in distinct agonist/antagonist activity profiles for estrogen re... J Med Chem. 2006 Dec 14;49(25):7357-65. DMQUZSJ RU https://pubmed.ncbi.nlm.nih.gov/17149865 DMQUZSJ DI DMQUZSJ DMQUZSJ DN 8-(2-methylpropyl)naringenin DMQUZSJ MI TTOM3J0 DMQUZSJ MN Estrogen receptor beta (ESR2) DMQUZSJ MT DTT DMQUZSJ MA Inhibitor DMQUZSJ RN Subtle side-chain modifications of the hop phytoestrogen 8-prenylnaringenin result in distinct agonist/antagonist activity profiles for estrogen re... J Med Chem. 2006 Dec 14;49(25):7357-65. DMQUZSJ RU https://pubmed.ncbi.nlm.nih.gov/17149865 DMRUP0A DI DMRUP0A DMRUP0A DN 8-(3,3,3-trifluoropropoxy)quinolin-2-amine DMRUP0A MI TTX4RTB DMRUP0A MN Melanin-concentrating hormone receptor 1 (MCHR1) DMRUP0A MT DTT DMRUP0A MA Inhibitor DMRUP0A RN Synthesis and evaluation of 2-amino-8-alkoxy quinolines as MCHr1 antagonists. Part 1. Bioorg Med Chem Lett. 2004 Oct 4;14(19):4873-7. DMRUP0A RU https://pubmed.ncbi.nlm.nih.gov/15341942 DM72EM9 DI DM72EM9 DM72EM9 DN 8-(3,3-Dimethyl-butoxy)-quinolin-2-ylamine DM72EM9 MI TTX4RTB DM72EM9 MN Melanin-concentrating hormone receptor 1 (MCHR1) DM72EM9 MT DTT DM72EM9 MA Inhibitor DM72EM9 RN Synthesis and evaluation of 2-amino-8-alkoxy quinolines as MCHr1 antagonists. Part 1. Bioorg Med Chem Lett. 2004 Oct 4;14(19):4873-7. DM72EM9 RU https://pubmed.ncbi.nlm.nih.gov/15341942 DMV63G1 DI DMV63G1 DMV63G1 DN 8-(3,4,5-trimethoxyphenyl)-9H-purine-2,6-diamine DMV63G1 MI TT9SL3Q DMV63G1 MN Polypeptide deformylase (PDF) DMV63G1 MT DTT DMV63G1 MA Inhibitor DMV63G1 RN CoMFA analysis of tgDHFR and rlDHFR based on antifolates with 6-5 fused ring system using the all-orientation search (AOS) routine and a modified c... Bioorg Med Chem. 2010 Feb 15;18(4):1684-701. DMV63G1 RU https://pubmed.ncbi.nlm.nih.gov/20117005 DMZU0YF DI DMZU0YF DMZU0YF DN 8-(3,4-dichlorophenyl)-9H-purine-2,6-diamine DMZU0YF MI TT9SL3Q DMZU0YF MN Polypeptide deformylase (PDF) DMZU0YF MT DTT DMZU0YF MA Inhibitor DMZU0YF RN CoMFA analysis of tgDHFR and rlDHFR based on antifolates with 6-5 fused ring system using the all-orientation search (AOS) routine and a modified c... Bioorg Med Chem. 2010 Feb 15;18(4):1684-701. DMZU0YF RU https://pubmed.ncbi.nlm.nih.gov/20117005 DMYZC3I DI DMYZC3I DMYZC3I DN 8-(3,4-dimethoxyphenyl)-9H-purine-2,6-diamine DMYZC3I MI TT9SL3Q DMYZC3I MN Polypeptide deformylase (PDF) DMYZC3I MT DTT DMYZC3I MA Inhibitor DMYZC3I RN CoMFA analysis of tgDHFR and rlDHFR based on antifolates with 6-5 fused ring system using the all-orientation search (AOS) routine and a modified c... Bioorg Med Chem. 2010 Feb 15;18(4):1684-701. DMYZC3I RU https://pubmed.ncbi.nlm.nih.gov/20117005 DM920XR DI DM920XR DM920XR DN 8-(3,5-dimethoxyphenyl)-9H-purine-2,6-diamine DM920XR MI TT9SL3Q DM920XR MN Polypeptide deformylase (PDF) DM920XR MT DTT DM920XR MA Inhibitor DM920XR RN CoMFA analysis of tgDHFR and rlDHFR based on antifolates with 6-5 fused ring system using the all-orientation search (AOS) routine and a modified c... Bioorg Med Chem. 2010 Feb 15;18(4):1684-701. DM920XR RU https://pubmed.ncbi.nlm.nih.gov/20117005 DM9J2LT DI DM9J2LT DM9J2LT DN 8-(3-Azido-phenyl)-6-iodo-quinoline DM9J2LT MI TTZ97H5 DM9J2LT MN Phosphodiesterase 4A (PDE4A) DM9J2LT MT DTT DM9J2LT MA Inhibitor DM9J2LT RN Hunting the emesis and efficacy targets of PDE4 inhibitors: identification of the photoaffinity probe 8-(3-azidophenyl)-6- [(4-iodo-1H-1-imidazolyl... J Med Chem. 2000 Oct 19;43(21):3820-3. DM9J2LT RU https://pubmed.ncbi.nlm.nih.gov/11052785 DMON7RZ DI DMON7RZ DMON7RZ DN 8-(3-Azido-phenyl)-6-pyridin-4-ylmethyl-quinoline DMON7RZ MI TTZ97H5 DMON7RZ MN Phosphodiesterase 4A (PDE4A) DMON7RZ MT DTT DMON7RZ MA Inhibitor DMON7RZ RN Hunting the emesis and efficacy targets of PDE4 inhibitors: identification of the photoaffinity probe 8-(3-azidophenyl)-6- [(4-iodo-1H-1-imidazolyl... J Med Chem. 2000 Oct 19;43(21):3820-3. DMON7RZ RU https://pubmed.ncbi.nlm.nih.gov/11052785 DMW2NJR DI DMW2NJR DMW2NJR DN 8-(3-Benzoyl-ureido)-octanoic acid hydroxyamide DMW2NJR MI TT6R7JZ DMW2NJR MN Histone deacetylase 1 (HDAC1) DMW2NJR MT DTT DMW2NJR MA Inhibitor DMW2NJR RN Acylurea connected straight chain hydroxamates as novel histone deacetylase inhibitors: Synthesis, SAR, and in vivo antitumor activity. Bioorg Med Chem Lett. 2010 Jun 1;20(11):3314-21. DMW2NJR RU https://pubmed.ncbi.nlm.nih.gov/20451378 DM2RA4N DI DM2RA4N DM2RA4N DN 8-(3-Bromobenzyloxy)caffeine DM2RA4N MI TT3WG5C DM2RA4N MN Monoamine oxidase type A (MAO-A) DM2RA4N MT DTT DM2RA4N MA Inhibitor DM2RA4N RN Inhibition of monoamine oxidase by 8-benzyloxycaffeine analogues. Bioorg Med Chem. 2010 Feb;18(3):1018-28. DM2RA4N RU https://pubmed.ncbi.nlm.nih.gov/20093036 DM2RA4N DI DM2RA4N DM2RA4N DN 8-(3-Bromobenzyloxy)caffeine DM2RA4N MI TTGP7BY DM2RA4N MN Monoamine oxidase type B (MAO-B) DM2RA4N MT DTT DM2RA4N MA Inhibitor DM2RA4N RN Inhibition of monoamine oxidase by 8-benzyloxycaffeine analogues. Bioorg Med Chem. 2010 Feb;18(3):1018-28. DM2RA4N RU https://pubmed.ncbi.nlm.nih.gov/20093036 DM7HMNP DI DM7HMNP DM7HMNP DN 8-(3-Chlorobenzyloxy)caffeine DM7HMNP MI TT3WG5C DM7HMNP MN Monoamine oxidase type A (MAO-A) DM7HMNP MT DTT DM7HMNP MA Inhibitor DM7HMNP RN Inhibition of monoamine oxidase by 8-benzyloxycaffeine analogues. Bioorg Med Chem. 2010 Feb;18(3):1018-28. DM7HMNP RU https://pubmed.ncbi.nlm.nih.gov/20093036 DM7HMNP DI DM7HMNP DM7HMNP DN 8-(3-Chlorobenzyloxy)caffeine DM7HMNP MI TTGP7BY DM7HMNP MN Monoamine oxidase type B (MAO-B) DM7HMNP MT DTT DM7HMNP MA Inhibitor DM7HMNP RN Inhibition of monoamine oxidase by 8-benzyloxycaffeine analogues. Bioorg Med Chem. 2010 Feb;18(3):1018-28. DM7HMNP RU https://pubmed.ncbi.nlm.nih.gov/20093036 DME85GS DI DME85GS DME85GS DN 8-(3-Fluorobenzyloxy)caffeine DME85GS MI TT3WG5C DME85GS MN Monoamine oxidase type A (MAO-A) DME85GS MT DTT DME85GS MA Inhibitor DME85GS RN Inhibition of monoamine oxidase by 8-benzyloxycaffeine analogues. Bioorg Med Chem. 2010 Feb;18(3):1018-28. DME85GS RU https://pubmed.ncbi.nlm.nih.gov/20093036 DME85GS DI DME85GS DME85GS DN 8-(3-Fluorobenzyloxy)caffeine DME85GS MI TTGP7BY DME85GS MN Monoamine oxidase type B (MAO-B) DME85GS MT DTT DME85GS MA Inhibitor DME85GS RN Inhibition of monoamine oxidase by 8-benzyloxycaffeine analogues. Bioorg Med Chem. 2010 Feb;18(3):1018-28. DME85GS RU https://pubmed.ncbi.nlm.nih.gov/20093036 DMLQPVH DI DMLQPVH DMLQPVH DN 8-(3-Fluoro-phenyl)-9-methyl-9H-purin-6-ylamine DMLQPVH MI TTNE7KG DMLQPVH MN Adenosine A2b receptor (ADORA2B) DMLQPVH MT DTT DMLQPVH MA Inhibitor DMLQPVH RN 2-Alkynyl-8-aryl-9-methyladenines as novel adenosine receptor antagonists: their synthesis and structure-activity relationships toward hepatic gluc... J Med Chem. 2001 Jan 18;44(2):170-9. DMLQPVH RU https://pubmed.ncbi.nlm.nih.gov/11170626 DM15LVG DI DM15LVG DM15LVG DN 8-(3-hydroxyphenyl)-2-morpholin-4-ylchromen-4-one DM15LVG MI TTK3PY9 DM15LVG MN DNA-dependent protein kinase catalytic (PRKDC) DM15LVG MT DTT DM15LVG MA Inhibitor DM15LVG RN Discovery of potent chromen-4-one inhibitors of the DNA-dependent protein kinase (DNA-PK) using a small-molecule library approach. J Med Chem. 2005 Dec 1;48(24):7829-46. DM15LVG RU https://pubmed.ncbi.nlm.nih.gov/16302822 DM3WEQA DI DM3WEQA DM3WEQA DN 8-(3-Methoxy-3-methyl-butoxy)-quinolin-2-ylamine DM3WEQA MI TTX4RTB DM3WEQA MN Melanin-concentrating hormone receptor 1 (MCHR1) DM3WEQA MT DTT DM3WEQA MA Inhibitor DM3WEQA RN Synthesis and evaluation of 2-amino-8-alkoxy quinolines as MCHr1 antagonists. Part 1. Bioorg Med Chem Lett. 2004 Oct 4;14(19):4873-7. DM3WEQA RU https://pubmed.ncbi.nlm.nih.gov/15341942 DMLY46X DI DMLY46X DMLY46X DN 8-(3-Methoxybenzyloxy)caffeine DMLY46X MI TT3WG5C DMLY46X MN Monoamine oxidase type A (MAO-A) DMLY46X MT DTT DMLY46X MA Inhibitor DMLY46X RN Inhibition of monoamine oxidase by 8-benzyloxycaffeine analogues. Bioorg Med Chem. 2010 Feb;18(3):1018-28. DMLY46X RU https://pubmed.ncbi.nlm.nih.gov/20093036 DMLY46X DI DMLY46X DMLY46X DN 8-(3-Methoxybenzyloxy)caffeine DMLY46X MI TTGP7BY DMLY46X MN Monoamine oxidase type B (MAO-B) DMLY46X MT DTT DMLY46X MA Inhibitor DMLY46X RN Inhibition of monoamine oxidase by 8-benzyloxycaffeine analogues. Bioorg Med Chem. 2010 Feb;18(3):1018-28. DMLY46X RU https://pubmed.ncbi.nlm.nih.gov/20093036 DMB9645 DI DMB9645 DMB9645 DN 8-(3-Methylbenzyloxy)caffeine DMB9645 MI TT3WG5C DMB9645 MN Monoamine oxidase type A (MAO-A) DMB9645 MT DTT DMB9645 MA Inhibitor DMB9645 RN Inhibition of monoamine oxidase by 8-benzyloxycaffeine analogues. Bioorg Med Chem. 2010 Feb;18(3):1018-28. DMB9645 RU https://pubmed.ncbi.nlm.nih.gov/20093036 DMB9645 DI DMB9645 DMB9645 DN 8-(3-Methylbenzyloxy)caffeine DMB9645 MI TTGP7BY DMB9645 MN Monoamine oxidase type B (MAO-B) DMB9645 MT DTT DMB9645 MA Inhibitor DMB9645 RN Inhibition of monoamine oxidase by 8-benzyloxycaffeine analogues. Bioorg Med Chem. 2010 Feb;18(3):1018-28. DMB9645 RU https://pubmed.ncbi.nlm.nih.gov/20093036 DMNYPCQ DI DMNYPCQ DMNYPCQ DN 8-(3-Methyl-butoxy)-quinolin-2-ylamine DMNYPCQ MI TTX4RTB DMNYPCQ MN Melanin-concentrating hormone receptor 1 (MCHR1) DMNYPCQ MT DTT DMNYPCQ MA Inhibitor DMNYPCQ RN Synthesis and evaluation of 2-amino-8-alkoxy quinolines as MCHr1 antagonists. Part 1. Bioorg Med Chem Lett. 2004 Oct 4;14(19):4873-7. DMNYPCQ RU https://pubmed.ncbi.nlm.nih.gov/15341942 DM2VAJE DI DM2VAJE DM2VAJE DN 8-(3-methylbutyl)naringenin DM2VAJE MI TTZAYWL DM2VAJE MN Estrogen receptor (ESR) DM2VAJE MT DTT DM2VAJE MA Inhibitor DM2VAJE RN Subtle side-chain modifications of the hop phytoestrogen 8-prenylnaringenin result in distinct agonist/antagonist activity profiles for estrogen re... J Med Chem. 2006 Dec 14;49(25):7357-65. DM2VAJE RU https://pubmed.ncbi.nlm.nih.gov/17149865 DM2VAJE DI DM2VAJE DM2VAJE DN 8-(3-methylbutyl)naringenin DM2VAJE MI TTOM3J0 DM2VAJE MN Estrogen receptor beta (ESR2) DM2VAJE MT DTT DM2VAJE MA Inhibitor DM2VAJE RN Subtle side-chain modifications of the hop phytoestrogen 8-prenylnaringenin result in distinct agonist/antagonist activity profiles for estrogen re... J Med Chem. 2006 Dec 14;49(25):7357-65. DM2VAJE RU https://pubmed.ncbi.nlm.nih.gov/17149865 DMPMJHV DI DMPMJHV DMPMJHV DN 8-(3-Methyl-cyclohexyloxy)-quinolin-2-ylamine DMPMJHV MI TTX4RTB DMPMJHV MN Melanin-concentrating hormone receptor 1 (MCHR1) DMPMJHV MT DTT DMPMJHV MA Inhibitor DMPMJHV RN Synthesis and evaluation of 2-amino-8-alkoxy quinolines as MCHr1 antagonists. Part 1. Bioorg Med Chem Lett. 2004 Oct 4;14(19):4873-7. DMPMJHV RU https://pubmed.ncbi.nlm.nih.gov/15341942 DM8N314 DI DM8N314 DM8N314 DN 8-(3-Methyl-cyclopentyloxy)-quinolin-2-ylamine DM8N314 MI TTX4RTB DM8N314 MN Melanin-concentrating hormone receptor 1 (MCHR1) DM8N314 MT DTT DM8N314 MA Inhibitor DM8N314 RN Synthesis and evaluation of 2-amino-8-alkoxy quinolines as MCHr1 antagonists. Part 1. Bioorg Med Chem Lett. 2004 Oct 4;14(19):4873-7. DM8N314 RU https://pubmed.ncbi.nlm.nih.gov/15341942 DMP6Z3R DI DMP6Z3R DMP6Z3R DN 8-(3-Nitro-phenyl)-6-phenyl-[1,7]naphthyridine DMP6Z3R MI TTZ97H5 DMP6Z3R MN Phosphodiesterase 4A (PDE4A) DMP6Z3R MT DTT DMP6Z3R MA Inhibitor DMP6Z3R RN Palladium-catalyzed cross-coupling reactions for the synthesis of 6, 8-disubstituted 1,7-naphthyridines: a novel class of potent and selective phos... J Med Chem. 2000 Feb 24;43(4):675-82. DMP6Z3R RU https://pubmed.ncbi.nlm.nih.gov/10691693 DMP6Z3R DI DMP6Z3R DMP6Z3R DN 8-(3-Nitro-phenyl)-6-phenyl-[1,7]naphthyridine DMP6Z3R MI TTVIAT9 DMP6Z3R MN Phosphodiesterase 4B (PDE4B) DMP6Z3R MT DTT DMP6Z3R MA Inhibitor DMP6Z3R RN Palladium-catalyzed cross-coupling reactions for the synthesis of 6, 8-disubstituted 1,7-naphthyridines: a novel class of potent and selective phos... J Med Chem. 2000 Feb 24;43(4):675-82. DMP6Z3R RU https://pubmed.ncbi.nlm.nih.gov/10691693 DM0N68L DI DM0N68L DM0N68L DN 8-(3-Nitro-phenyl)-6-pyridin-4-ylmethyl-quinoline DM0N68L MI TTZ97H5 DM0N68L MN Phosphodiesterase 4A (PDE4A) DM0N68L MT DTT DM0N68L MA Inhibitor DM0N68L RN Hunting the emesis and efficacy targets of PDE4 inhibitors: identification of the photoaffinity probe 8-(3-azidophenyl)-6- [(4-iodo-1H-1-imidazolyl... J Med Chem. 2000 Oct 19;43(21):3820-3. DM0N68L RU https://pubmed.ncbi.nlm.nih.gov/11052785 DMAK0P3 DI DMAK0P3 DMAK0P3 DN 8-(4-acetylphenyl)-2-morpholin-4-ylchromen-4-one DMAK0P3 MI TTK3PY9 DMAK0P3 MN DNA-dependent protein kinase catalytic (PRKDC) DMAK0P3 MT DTT DMAK0P3 MA Inhibitor DMAK0P3 RN Discovery of potent chromen-4-one inhibitors of the DNA-dependent protein kinase (DNA-PK) using a small-molecule library approach. J Med Chem. 2005 Dec 1;48(24):7829-46. DMAK0P3 RU https://pubmed.ncbi.nlm.nih.gov/16302822 DMVOCWY DI DMVOCWY DMVOCWY DN 8-(4-bromophenyl)-N-hydroxy-8-oxooctanamide DMVOCWY MI TT6R7JZ DMVOCWY MN Histone deacetylase 1 (HDAC1) DMVOCWY MT DTT DMVOCWY MA Inhibitor DMVOCWY RN 3D-QSAR studies of HDACs inhibitors using pharmacophore-based alignment. Eur J Med Chem. 2009 Jul;44(7):2868-76. DMVOCWY RU https://pubmed.ncbi.nlm.nih.gov/19136179 DM4186A DI DM4186A DM4186A DN 8-(4-chlorophenyl)-2-morpholin-4-ylchromen-4-one DM4186A MI TTK3PY9 DM4186A MN DNA-dependent protein kinase catalytic (PRKDC) DM4186A MT DTT DM4186A MA Inhibitor DM4186A RN Discovery of potent chromen-4-one inhibitors of the DNA-dependent protein kinase (DNA-PK) using a small-molecule library approach. J Med Chem. 2005 Dec 1;48(24):7829-46. DM4186A RU https://pubmed.ncbi.nlm.nih.gov/16302822 DMLANGY DI DMLANGY DMLANGY DN 8-(4-hydroxyphenyl)-2-morpholin-4-ylchromen-4-one DMLANGY MI TTK3PY9 DMLANGY MN DNA-dependent protein kinase catalytic (PRKDC) DMLANGY MT DTT DMLANGY MA Inhibitor DMLANGY RN Discovery of potent chromen-4-one inhibitors of the DNA-dependent protein kinase (DNA-PK) using a small-molecule library approach. J Med Chem. 2005 Dec 1;48(24):7829-46. DMLANGY RU https://pubmed.ncbi.nlm.nih.gov/16302822 DMPVQN3 DI DMPVQN3 DMPVQN3 DN 8-(4-Methyl-cyclohexyloxy)-quinolin-2-ylamine DMPVQN3 MI TTX4RTB DMPVQN3 MN Melanin-concentrating hormone receptor 1 (MCHR1) DMPVQN3 MT DTT DMPVQN3 MA Inhibitor DMPVQN3 RN Synthesis and evaluation of 2-amino-8-alkoxy quinolines as MCHr1 antagonists. Part 1. Bioorg Med Chem Lett. 2004 Oct 4;14(19):4873-7. DMPVQN3 RU https://pubmed.ncbi.nlm.nih.gov/15341942 DMH3SDO DI DMH3SDO DMH3SDO DN 8-(Biphenyl-3-yloxy)-1,1,1-trifluoro-octan-2-one DMH3SDO MI TT6R7JZ DMH3SDO MN Histone deacetylase 1 (HDAC1) DMH3SDO MT DTT DMH3SDO MA Inhibitor DMH3SDO RN Trifluoromethyl ketones as inhibitors of histone deacetylase. Bioorg Med Chem Lett. 2002 Dec 2;12(23):3443-7. DMH3SDO RU https://pubmed.ncbi.nlm.nih.gov/12419380 DMH3SDO DI DMH3SDO DMH3SDO DN 8-(Biphenyl-3-yloxy)-1,1,1-trifluoro-octan-2-one DMH3SDO MI TTSHTOI DMH3SDO MN Histone deacetylase 2 (HDAC2) DMH3SDO MT DTT DMH3SDO MA Inhibitor DMH3SDO RN Trifluoromethyl ketones as inhibitors of histone deacetylase. Bioorg Med Chem Lett. 2002 Dec 2;12(23):3443-7. DMH3SDO RU https://pubmed.ncbi.nlm.nih.gov/12419380 DMD6VSY DI DMD6VSY DMD6VSY DN 8-(biphenyl-4-yl)-N-hydroxy-8-oxooctanamide DMD6VSY MI TT6R7JZ DMD6VSY MN Histone deacetylase 1 (HDAC1) DMD6VSY MT DTT DMD6VSY MA Inhibitor DMD6VSY RN 3D-QSAR studies of HDACs inhibitors using pharmacophore-based alignment. Eur J Med Chem. 2009 Jul;44(7):2868-76. DMD6VSY RU https://pubmed.ncbi.nlm.nih.gov/19136179 DM23XGW DI DM23XGW DM23XGW DN 8-(Biphenyl-4-yloxy)-1,1,1-trifluoro-octan-2-one DM23XGW MI TTBH0VX DM23XGW MN Histone deacetylase (HDAC) DM23XGW MT DTT DM23XGW MA Inhibitor DM23XGW RN Heterocyclic ketones as inhibitors of histone deacetylase. Bioorg Med Chem Lett. 2003 Nov 17;13(22):3909-13. DM23XGW RU https://pubmed.ncbi.nlm.nih.gov/14592473 DM23XGW DI DM23XGW DM23XGW DN 8-(Biphenyl-4-yloxy)-1,1,1-trifluoro-octan-2-one DM23XGW MI TT6R7JZ DM23XGW MN Histone deacetylase 1 (HDAC1) DM23XGW MT DTT DM23XGW MA Inhibitor DM23XGW RN Trifluoromethyl ketones as inhibitors of histone deacetylase. Bioorg Med Chem Lett. 2002 Dec 2;12(23):3443-7. DM23XGW RU https://pubmed.ncbi.nlm.nih.gov/12419380 DM23XGW DI DM23XGW DM23XGW DN 8-(Biphenyl-4-yloxy)-1,1,1-trifluoro-octan-2-one DM23XGW MI TTYHPU6 DM23XGW MN Histone deacetylase 10 (HDAC10) DM23XGW MT DTT DM23XGW MA Inhibitor DM23XGW RN Heterocyclic ketones as inhibitors of histone deacetylase. Bioorg Med Chem Lett. 2003 Nov 17;13(22):3909-13. DM23XGW RU https://pubmed.ncbi.nlm.nih.gov/14592473 DM23XGW DI DM23XGW DM23XGW DN 8-(Biphenyl-4-yloxy)-1,1,1-trifluoro-octan-2-one DM23XGW MI TTSHTOI DM23XGW MN Histone deacetylase 2 (HDAC2) DM23XGW MT DTT DM23XGW MA Inhibitor DM23XGW RN Trifluoromethyl ketones as inhibitors of histone deacetylase. Bioorg Med Chem Lett. 2002 Dec 2;12(23):3443-7. DM23XGW RU https://pubmed.ncbi.nlm.nih.gov/12419380 DM23XGW DI DM23XGW DM23XGW DN 8-(Biphenyl-4-yloxy)-1,1,1-trifluoro-octan-2-one DM23XGW MI TTTQGH8 DM23XGW MN Histone deacetylase 4 (HDAC4) DM23XGW MT DTT DM23XGW MA Inhibitor DM23XGW RN Heterocyclic ketones as inhibitors of histone deacetylase. Bioorg Med Chem Lett. 2003 Nov 17;13(22):3909-13. DM23XGW RU https://pubmed.ncbi.nlm.nih.gov/14592473 DM23XGW DI DM23XGW DM23XGW DN 8-(Biphenyl-4-yloxy)-1,1,1-trifluoro-octan-2-one DM23XGW MI TT5ZKDI DM23XGW MN Histone deacetylase 6 (HDAC6) DM23XGW MT DTT DM23XGW MA Inhibitor DM23XGW RN Heterocyclic ketones as inhibitors of histone deacetylase. Bioorg Med Chem Lett. 2003 Nov 17;13(22):3909-13. DM23XGW RU https://pubmed.ncbi.nlm.nih.gov/14592473 DM23XGW DI DM23XGW DM23XGW DN 8-(Biphenyl-4-yloxy)-1,1,1-trifluoro-octan-2-one DM23XGW MI TTT6LFV DM23XGW MN Histone deacetylase 8 (HDAC8) DM23XGW MT DTT DM23XGW MA Inhibitor DM23XGW RN Heterocyclic ketones as inhibitors of histone deacetylase. Bioorg Med Chem Lett. 2003 Nov 17;13(22):3909-13. DM23XGW RU https://pubmed.ncbi.nlm.nih.gov/14592473 DMDIGPW DI DMDIGPW DMDIGPW DN 8-(Biphenyl-4-yloxy)-2-oxo-octanoic acid DMDIGPW MI TT6R7JZ DMDIGPW MN Histone deacetylase 1 (HDAC1) DMDIGPW MT DTT DMDIGPW MA Inhibitor DMDIGPW RN Alpha-keto amides as inhibitors of histone deacetylase. Bioorg Med Chem Lett. 2003 Oct 6;13(19):3331-5. DMDIGPW RU https://pubmed.ncbi.nlm.nih.gov/12951120 DMDIGPW DI DMDIGPW DMDIGPW DN 8-(Biphenyl-4-yloxy)-2-oxo-octanoic acid DMDIGPW MI TTSHTOI DMDIGPW MN Histone deacetylase 2 (HDAC2) DMDIGPW MT DTT DMDIGPW MA Inhibitor DMDIGPW RN Alpha-keto amides as inhibitors of histone deacetylase. Bioorg Med Chem Lett. 2003 Oct 6;13(19):3331-5. DMDIGPW RU https://pubmed.ncbi.nlm.nih.gov/12951120 DMT1NW2 DI DMT1NW2 DMT1NW2 DN 8(S)-amino-2(R)-methyl-7-oxononanoic acid DMT1NW2 MI TTXZEAJ DMT1NW2 MN Leukotriene A-4 hydrolase (LTA4H) DMT1NW2 MT DTT DMT1NW2 MA Inhibitor DMT1NW2 RN Isolation and structure of leukotriene-A4 hydrolase inhibitor: 8(S)-amino-2(R)-methyl-7-oxononanoic acid produced by Streptomyces diastaticus. J Nat Prod. 1996 Oct;59(10):962-4. DMT1NW2 RU https://pubmed.ncbi.nlm.nih.gov/8904845 DMT3IOB DI DMT3IOB DMT3IOB DN 8-[(3-Trifluoromethyl)benzyloxy]caffeine DMT3IOB MI TT3WG5C DMT3IOB MN Monoamine oxidase type A (MAO-A) DMT3IOB MT DTT DMT3IOB MA Inhibitor DMT3IOB RN Inhibition of monoamine oxidase by 8-benzyloxycaffeine analogues. Bioorg Med Chem. 2010 Feb;18(3):1018-28. DMT3IOB RU https://pubmed.ncbi.nlm.nih.gov/20093036 DMT3IOB DI DMT3IOB DMT3IOB DN 8-[(3-Trifluoromethyl)benzyloxy]caffeine DMT3IOB MI TTGP7BY DMT3IOB MN Monoamine oxidase type B (MAO-B) DMT3IOB MT DTT DMT3IOB MA Inhibitor DMT3IOB RN Inhibition of monoamine oxidase by 8-benzyloxycaffeine analogues. Bioorg Med Chem. 2010 Feb;18(3):1018-28. DMT3IOB RU https://pubmed.ncbi.nlm.nih.gov/20093036 DM4R2EX DI DM4R2EX DM4R2EX DN 8-acetyl-7-(benzyloxy)-2H-chromen-2-one DM4R2EX MI TT2LVK8 DM4R2EX MN Carbonic anhydrase IX (CA-IX) DM4R2EX MT DTT DM4R2EX MA Inhibitor DM4R2EX RN 7,8-disubstituted- but not 6,7-disubstituted coumarins selectively inhibit the transmembrane, tumor-associated carbonic anhydrase isoforms IX and X... Bioorg Med Chem Lett. 2010 Dec 15;20(24):7255-8. DM4R2EX RU https://pubmed.ncbi.nlm.nih.gov/21067924 DMCTWBL DI DMCTWBL DMCTWBL DN 8-acetyl-7-butoxy-2H-chromen-2-one DMCTWBL MI TT2LVK8 DMCTWBL MN Carbonic anhydrase IX (CA-IX) DMCTWBL MT DTT DMCTWBL MA Inhibitor DMCTWBL RN 7,8-disubstituted- but not 6,7-disubstituted coumarins selectively inhibit the transmembrane, tumor-associated carbonic anhydrase isoforms IX and X... Bioorg Med Chem Lett. 2010 Dec 15;20(24):7255-8. DMCTWBL RU https://pubmed.ncbi.nlm.nih.gov/21067924 DMDV8UT DI DMDV8UT DMDV8UT DN 8-acetyl-7-ethoxy-2H-chromen-2-one DMDV8UT MI TT2LVK8 DMDV8UT MN Carbonic anhydrase IX (CA-IX) DMDV8UT MT DTT DMDV8UT MA Inhibitor DMDV8UT RN 7,8-disubstituted- but not 6,7-disubstituted coumarins selectively inhibit the transmembrane, tumor-associated carbonic anhydrase isoforms IX and X... Bioorg Med Chem Lett. 2010 Dec 15;20(24):7255-8. DMDV8UT RU https://pubmed.ncbi.nlm.nih.gov/21067924 DMAMJW2 DI DMAMJW2 DMAMJW2 DN 8-Acetyl-7-hydroxy-2H-chromen-2-one DMAMJW2 MI TT2LVK8 DMAMJW2 MN Carbonic anhydrase IX (CA-IX) DMAMJW2 MT DTT DMAMJW2 MA Inhibitor DMAMJW2 RN 7,8-disubstituted- but not 6,7-disubstituted coumarins selectively inhibit the transmembrane, tumor-associated carbonic anhydrase isoforms IX and X... Bioorg Med Chem Lett. 2010 Dec 15;20(24):7255-8. DMAMJW2 RU https://pubmed.ncbi.nlm.nih.gov/21067924 DMZSJRC DI DMZSJRC DMZSJRC DN 8-acetyl-7-methoxy-2H-chromen-2-one DMZSJRC MI TT2LVK8 DMZSJRC MN Carbonic anhydrase IX (CA-IX) DMZSJRC MT DTT DMZSJRC MA Inhibitor DMZSJRC RN 7,8-disubstituted- but not 6,7-disubstituted coumarins selectively inhibit the transmembrane, tumor-associated carbonic anhydrase isoforms IX and X... Bioorg Med Chem Lett. 2010 Dec 15;20(24):7255-8. DMZSJRC RU https://pubmed.ncbi.nlm.nih.gov/21067924 DMGRK3V DI DMGRK3V DMGRK3V DN 8-acetyl-7-propoxy-2H-chromen-2-one DMGRK3V MI TT2LVK8 DMGRK3V MN Carbonic anhydrase IX (CA-IX) DMGRK3V MT DTT DMGRK3V MA Inhibitor DMGRK3V RN 7,8-disubstituted- but not 6,7-disubstituted coumarins selectively inhibit the transmembrane, tumor-associated carbonic anhydrase isoforms IX and X... Bioorg Med Chem Lett. 2010 Dec 15;20(24):7255-8. DMGRK3V RU https://pubmed.ncbi.nlm.nih.gov/21067924 DM7K2DN DI DM7K2DN DM7K2DN DN 8alpha,19-dihydroxylabd-13 E-en-15-oic acid DM7K2DN MI TTVKILB DM7K2DN MN Prostaglandin G/H synthase 2 (COX-2) DM7K2DN MT DTT DM7K2DN MA Inhibitor DM7K2DN RN Cyclooxygenase (COX)-1 and -2 inhibitory labdane diterpenes from Crassocephalum mannii. J Nat Prod. 2008 Jun;71(6):1070-3. DM7K2DN RU https://pubmed.ncbi.nlm.nih.gov/18473477 DM84D9W DI DM84D9W DM84D9W DN 8-Amino-1,3-Dimethyl-3,7-Dihydropurine-2,6-Dione DM84D9W MI TTG9CFY DM84D9W MN Bacterial Dihydroneopterinaldolase (Bact folB) DM84D9W MT DTT DM84D9W MA Inhibitor DM84D9W RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DM84D9W RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMTRBDP DI DMTRBDP DMTRBDP DN 8-Amino-6H,11H-indeno[1,2-c]isoquinolin-5-one DMTRBDP MI TTVDSZ0 DMTRBDP MN Poly [ADP-ribose] polymerase 1 (PARP1) DMTRBDP MT DTT DMTRBDP MA Inhibitor DMTRBDP RN Discovery of potent poly(ADP-ribose) polymerase-1 inhibitors from the modification of indeno[1,2-c]isoquinolinone. J Med Chem. 2005 Aug 11;48(16):5100-3. DMTRBDP RU https://pubmed.ncbi.nlm.nih.gov/16078828 DMSNG7M DI DMSNG7M DMSNG7M DN 8-amino-9-benzylguanine DMSNG7M MI TTMCF1Y DMSNG7M MN Purine nucleoside phosphorylase (PNP) DMSNG7M MT DTT DMSNG7M MA Inhibitor DMSNG7M RN Expression of human malaria parasite purine nucleoside phosphorylase in host enzyme-deficient erythrocyte culture. Enzyme characterization and identification of novel inhibitors. J Biol Chem. 1986 Sep 5;261(25):11667-73. DMSNG7M RU https://pubmed.ncbi.nlm.nih.gov/3091593 DMYXJG7 DI DMYXJG7 DMYXJG7 DN 8-AMINOGUANINE DMYXJG7 MI TTMCF1Y DMYXJG7 MN Purine nucleoside phosphorylase (PNP) DMYXJG7 MT DTT DMYXJG7 MA Inhibitor DMYXJG7 RN Nucleosides. 5. Synthesis of guanine and formycin B derivatives as potential inhibitors of purine nucleoside phosphorylase. J Med Chem. 1993 Apr 16;36(8):1024-31. DMYXJG7 RU https://pubmed.ncbi.nlm.nih.gov/8478902 DM0JEA6 DI DM0JEA6 DM0JEA6 DN 8-aminoguanosine DM0JEA6 MI TTMCF1Y DM0JEA6 MN Purine nucleoside phosphorylase (PNP) DM0JEA6 MT DTT DM0JEA6 MA Inhibitor DM0JEA6 RN Differential metabolism of guanine nucleosides by human lymphoid cell lines. Proc Soc Exp Biol Med. 1985 Sep;179(4):427-31. DM0JEA6 RU https://pubmed.ncbi.nlm.nih.gov/3875100 DMN8QAF DI DMN8QAF DMN8QAF DN 8-aminoquinolines DMN8QAF MI TTJSZTB DMN8QAF MN Nicotinic acetylcholine receptor (nAChR) DMN8QAF MT DTT DMN8QAF MA Antagonist DMN8QAF RN Opioids induce while nicotine suppresses apoptosis in human lung cancer cells. Cell Growth Differ. 1994 Oct;5(10):1033-40. DMN8QAF RU https://pubmed.ncbi.nlm.nih.gov/7848904 DMN8QAF DI DMN8QAF DMN8QAF DN 8-aminoquinolines DMN8QAF MI TT3PQ2Y DMN8QAF MN Plasmodium Dihydroorotate dehydrogenase (Malaria DHOdehase) DMN8QAF MT DTT DMN8QAF MA Inhibitor DMN8QAF RN The effects of antimalarials on the Plasmodium falciparum dihydroorotate dehydrogenase. Exp Parasitol. 1994 Aug;79(1):50-6. DMN8QAF RU https://pubmed.ncbi.nlm.nih.gov/8050525 DMYBPGA DI DMYBPGA DMYBPGA DN 8-aza-11-deoxyprostaglandin E1 DMYBPGA MI TT79WV3 DMYBPGA MN Prostaglandin E2 receptor EP4 (PTGER4) DMYBPGA MT DTT DMYBPGA MA Inhibitor DMYBPGA RN Lactams as EP4 prostanoid receptor agonists. 3. Discovery of N-ethylbenzoic acid 2-pyrrolidinones as subtype selective agents. J Med Chem. 2004 Dec 2;47(25):6124-7. DMYBPGA RU https://pubmed.ncbi.nlm.nih.gov/15566283 DMQMSZR DI DMQMSZR DMQMSZR DN 8-azabicyclo[3.2.1]octan-3-yloxy-benzamide DMQMSZR MI TT27RFC DMQMSZR MN Opioid receptor delta (OPRD1) DMQMSZR MT DTT DMQMSZR MA Inhibitor DMQMSZR RN SAR development of a series of 8-azabicyclo[3.2.1]octan-3-yloxy-benzamides as kappa opioid receptor antagonists. Part 2. Bioorg Med Chem Lett. 2010 Sep 15;20(18):5405-10. DMQMSZR RU https://pubmed.ncbi.nlm.nih.gov/20719509 DMQMSZR DI DMQMSZR DMQMSZR DN 8-azabicyclo[3.2.1]octan-3-yloxy-benzamide DMQMSZR MI TTQW87Y DMQMSZR MN Opioid receptor kappa (OPRK1) DMQMSZR MT DTT DMQMSZR MA Inhibitor DMQMSZR RN SAR development of a series of 8-azabicyclo[3.2.1]octan-3-yloxy-benzamides as kappa opioid receptor antagonists. Part 2. Bioorg Med Chem Lett. 2010 Sep 15;20(18):5405-10. DMQMSZR RU https://pubmed.ncbi.nlm.nih.gov/20719509 DMQMSZR DI DMQMSZR DMQMSZR DN 8-azabicyclo[3.2.1]octan-3-yloxy-benzamide DMQMSZR MI TTKWM86 DMQMSZR MN Opioid receptor mu (MOP) DMQMSZR MT DTT DMQMSZR MA Inhibitor DMQMSZR RN SAR development of a series of 8-azabicyclo[3.2.1]octan-3-yloxy-benzamides as kappa opioid receptor antagonists. Part 2. Bioorg Med Chem Lett. 2010 Sep 15;20(18):5405-10. DMQMSZR RU https://pubmed.ncbi.nlm.nih.gov/20719509 DMQMSZR DI DMQMSZR DMQMSZR DN 8-azabicyclo[3.2.1]octan-3-yloxy-benzamide DMQMSZR MI TTQ6VDM DMQMSZR MN Voltage-gated potassium channel Kv11.1 (KCNH2) DMQMSZR MT DTT DMQMSZR MA Inhibitor DMQMSZR RN SAR development of a series of 8-azabicyclo[3.2.1]octan-3-yloxy-benzamides as kappa opioid receptor antagonists. Part 2. Bioorg Med Chem Lett. 2010 Sep 15;20(18):5405-10. DMQMSZR RU https://pubmed.ncbi.nlm.nih.gov/20719509 DMBVFKR DI DMBVFKR DMBVFKR DN 8-aza-DADMe-ImmH DMBVFKR MI TTMCF1Y DMBVFKR MN Purine nucleoside phosphorylase (PNP) DMBVFKR MT DTT DMBVFKR MA Inhibitor DMBVFKR RN Achieving the ultimate physiological goal in transition state analogue inhibitors for purine nucleoside phosphorylase. J Biol Chem. 2003 Aug 22;278(34):31465-8. DMBVFKR RU https://pubmed.ncbi.nlm.nih.gov/12842889 DM7VP90 DI DM7VP90 DM7VP90 DN 8-Azaguanine DM7VP90 MI TTMCF1Y DM7VP90 MN Purine nucleoside phosphorylase (PNP) DM7VP90 MT DTT DM7VP90 MA Inhibitor DM7VP90 RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DM7VP90 RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMT8QAP DI DMT8QAP DMT8QAP DN 8-BENZO[1,3]DIOXOL-,5-YLMETHYL-9-BUTYL-9H- DMT8QAP MI TT78R5H DMT8QAP MN Heat shock protein 90 alpha (HSP90A) DMT8QAP MT DTT DMT8QAP MA Inhibitor DMT8QAP RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DMT8QAP RU https://pubmed.ncbi.nlm.nih.gov/10592235 DM32OQB DI DM32OQB DM32OQB DN 8-benzyl-9H-purine-2,6-diamine DM32OQB MI TT9SL3Q DM32OQB MN Polypeptide deformylase (PDF) DM32OQB MT DTT DM32OQB MA Inhibitor DM32OQB RN CoMFA analysis of tgDHFR and rlDHFR based on antifolates with 6-5 fused ring system using the all-orientation search (AOS) routine and a modified c... Bioorg Med Chem. 2010 Feb 15;18(4):1684-701. DM32OQB RU https://pubmed.ncbi.nlm.nih.gov/20117005 DMKHF87 DI DMKHF87 DMKHF87 DN 8-benzylnaringenin DMKHF87 MI TTZAYWL DMKHF87 MN Estrogen receptor (ESR) DMKHF87 MT DTT DMKHF87 MA Inhibitor DMKHF87 RN Subtle side-chain modifications of the hop phytoestrogen 8-prenylnaringenin result in distinct agonist/antagonist activity profiles for estrogen re... J Med Chem. 2006 Dec 14;49(25):7357-65. DMKHF87 RU https://pubmed.ncbi.nlm.nih.gov/17149865 DMKHF87 DI DMKHF87 DMKHF87 DN 8-benzylnaringenin DMKHF87 MI TTOM3J0 DMKHF87 MN Estrogen receptor beta (ESR2) DMKHF87 MT DTT DMKHF87 MA Inhibitor DMKHF87 RN Subtle side-chain modifications of the hop phytoestrogen 8-prenylnaringenin result in distinct agonist/antagonist activity profiles for estrogen re... J Med Chem. 2006 Dec 14;49(25):7357-65. DMKHF87 RU https://pubmed.ncbi.nlm.nih.gov/17149865 DMJQ8AP DI DMJQ8AP DMJQ8AP DN 8-Benzyloxycaffeine DMJQ8AP MI TT3WG5C DMJQ8AP MN Monoamine oxidase type A (MAO-A) DMJQ8AP MT DTT DMJQ8AP MA Inhibitor DMJQ8AP RN Inhibition of monoamine oxidase by 8-benzyloxycaffeine analogues. Bioorg Med Chem. 2010 Feb;18(3):1018-28. DMJQ8AP RU https://pubmed.ncbi.nlm.nih.gov/20093036 DMJQ8AP DI DMJQ8AP DMJQ8AP DN 8-Benzyloxycaffeine DMJQ8AP MI TTGP7BY DMJQ8AP MN Monoamine oxidase type B (MAO-B) DMJQ8AP MT DTT DMJQ8AP MA Inhibitor DMJQ8AP RN Inhibition of monoamine oxidase by 8-benzyloxycaffeine analogues. Bioorg Med Chem. 2010 Feb;18(3):1018-28. DMJQ8AP RU https://pubmed.ncbi.nlm.nih.gov/20093036 DMMCAZG DI DMMCAZG DMMCAZG DN 8-biphenyl-2-yl-2-morpholin-4-ylchromen-4-one DMMCAZG MI TTK3PY9 DMMCAZG MN DNA-dependent protein kinase catalytic (PRKDC) DMMCAZG MT DTT DMMCAZG MA Inhibitor DMMCAZG RN Discovery of potent chromen-4-one inhibitors of the DNA-dependent protein kinase (DNA-PK) using a small-molecule library approach. J Med Chem. 2005 Dec 1;48(24):7829-46. DMMCAZG RU https://pubmed.ncbi.nlm.nih.gov/16302822 DMVPIYG DI DMVPIYG DMVPIYG DN 8-Br-adenine DMVPIYG MI TTM2AOE DMVPIYG MN Adenosine A2a receptor (ADORA2A) DMVPIYG MT DTT DMVPIYG MA Inhibitor DMVPIYG RN 8-Bromo-9-alkyl adenine derivatives as tools for developing new adenosine A2A and A2B receptors ligands. Bioorg Med Chem. 2009 Apr 1;17(7):2812-22. DMVPIYG RU https://pubmed.ncbi.nlm.nih.gov/19282184 DMALRU4 DI DMALRU4 DMALRU4 DN 8-Bromo-2,3,4,9-tetrahydro-1H-beta-carboline DMALRU4 MI TTJQOD7 DMALRU4 MN 5-HT 2A receptor (HTR2A) DMALRU4 MT DTT DMALRU4 MA Inhibitor DMALRU4 RN Binding of beta-carbolines at 5-HT(2) serotonin receptors. Bioorg Med Chem Lett. 2003 Dec 15;13(24):4421-5. DMALRU4 RU https://pubmed.ncbi.nlm.nih.gov/14643338 DMALRU4 DI DMALRU4 DMALRU4 DN 8-Bromo-2,3,4,9-tetrahydro-1H-beta-carboline DMALRU4 MI TT3WG5C DMALRU4 MN Monoamine oxidase type A (MAO-A) DMALRU4 MT DTT DMALRU4 MA Inhibitor DMALRU4 RN Binding of beta-carbolines at imidazoline I2 receptors: a structure-affinity investigation. Bioorg Med Chem Lett. 2004 Feb 23;14(4):999-1002. DMALRU4 RU https://pubmed.ncbi.nlm.nih.gov/15013009 DMALRU4 DI DMALRU4 DMALRU4 DN 8-Bromo-2,3,4,9-tetrahydro-1H-beta-carboline DMALRU4 MI TTGP7BY DMALRU4 MN Monoamine oxidase type B (MAO-B) DMALRU4 MT DTT DMALRU4 MA Inhibitor DMALRU4 RN Binding of beta-carbolines at imidazoline I2 receptors: a structure-affinity investigation. Bioorg Med Chem Lett. 2004 Feb 23;14(4):999-1002. DMALRU4 RU https://pubmed.ncbi.nlm.nih.gov/15013009 DMPVU7H DI DMPVU7H DMPVU7H DN 8-Bromo-3-hydroxy-1H-benzo[b]azepine-2,5-dione DMPVU7H MI TTLD29N DMPVU7H MN Glutamate receptor ionotropic NMDA 1 (NMDAR1) DMPVU7H MT DTT DMPVU7H MA Inhibitor DMPVU7H RN Analogs of 3-hydroxy-1H-1-benzazepine-2,5-dione: structure-activity relationship at N-methyl-D-aspartate receptor glycine sites. J Med Chem. 1996 Nov 8;39(23):4643-53. DMPVU7H RU https://pubmed.ncbi.nlm.nih.gov/8917653 DMPVU7H DI DMPVU7H DMPVU7H DN 8-Bromo-3-hydroxy-1H-benzo[b]azepine-2,5-dione DMPVU7H MI TTKJEMQ DMPVU7H MN Glutamate receptor ionotropic NMDA 2A (NMDAR2A) DMPVU7H MT DTT DMPVU7H MA Inhibitor DMPVU7H RN Analogs of 3-hydroxy-1H-1-benzazepine-2,5-dione: structure-activity relationship at N-methyl-D-aspartate receptor glycine sites. J Med Chem. 1996 Nov 8;39(23):4643-53. DMPVU7H RU https://pubmed.ncbi.nlm.nih.gov/8917653 DMPVU7H DI DMPVU7H DMPVU7H DN 8-Bromo-3-hydroxy-1H-benzo[b]azepine-2,5-dione DMPVU7H MI TTN9D8E DMPVU7H MN Glutamate receptor ionotropic NMDA 2B (NMDAR2B) DMPVU7H MT DTT DMPVU7H MA Inhibitor DMPVU7H RN Analogs of 3-hydroxy-1H-1-benzazepine-2,5-dione: structure-activity relationship at N-methyl-D-aspartate receptor glycine sites. J Med Chem. 1996 Nov 8;39(23):4643-53. DMPVU7H RU https://pubmed.ncbi.nlm.nih.gov/8917653 DM4V5RU DI DM4V5RU DM4V5RU DN 8-Bromo-4,9-dihydro-3H-beta-carboline DM4V5RU MI TTJQOD7 DM4V5RU MN 5-HT 2A receptor (HTR2A) DM4V5RU MT DTT DM4V5RU MA Inhibitor DM4V5RU RN Binding of beta-carbolines at 5-HT(2) serotonin receptors. Bioorg Med Chem Lett. 2003 Dec 15;13(24):4421-5. DM4V5RU RU https://pubmed.ncbi.nlm.nih.gov/14643338 DM4V5RU DI DM4V5RU DM4V5RU DN 8-Bromo-4,9-dihydro-3H-beta-carboline DM4V5RU MI TT3WG5C DM4V5RU MN Monoamine oxidase type A (MAO-A) DM4V5RU MT DTT DM4V5RU MA Inhibitor DM4V5RU RN Binding of beta-carbolines at imidazoline I2 receptors: a structure-affinity investigation. Bioorg Med Chem Lett. 2004 Feb 23;14(4):999-1002. DM4V5RU RU https://pubmed.ncbi.nlm.nih.gov/15013009 DM4V5RU DI DM4V5RU DM4V5RU DN 8-Bromo-4,9-dihydro-3H-beta-carboline DM4V5RU MI TTGP7BY DM4V5RU MN Monoamine oxidase type B (MAO-B) DM4V5RU MT DTT DM4V5RU MA Inhibitor DM4V5RU RN Binding of beta-carbolines at imidazoline I2 receptors: a structure-affinity investigation. Bioorg Med Chem Lett. 2004 Feb 23;14(4):999-1002. DM4V5RU RU https://pubmed.ncbi.nlm.nih.gov/15013009 DM51FL9 DI DM51FL9 DM51FL9 DN 8-Bromo-6-methyl-3-(4'-methoxyphenyl)coumarin DM51FL9 MI TTGP7BY DM51FL9 MN Monoamine oxidase type B (MAO-B) DM51FL9 MT DTT DM51FL9 MA Inhibitor DM51FL9 RN New halogenated 3-phenylcoumarins as potent and selective MAO-B inhibitors. Bioorg Med Chem Lett. 2010 Sep 1;20(17):5157-60. DM51FL9 RU https://pubmed.ncbi.nlm.nih.gov/20659799 DMD1LM8 DI DMD1LM8 DMD1LM8 DN 8-Bromo-6-methyl-3-phenylcoumarin DMD1LM8 MI TTGP7BY DMD1LM8 MN Monoamine oxidase type B (MAO-B) DMD1LM8 MT DTT DMD1LM8 MA Inhibitor DMD1LM8 RN New halogenated 3-phenylcoumarins as potent and selective MAO-B inhibitors. Bioorg Med Chem Lett. 2010 Sep 1;20(17):5157-60. DMD1LM8 RU https://pubmed.ncbi.nlm.nih.gov/20659799 DMKU06T DI DMKU06T DMKU06T DN 8-Bromo-6-styryl-naphthalene-2-carboxamidine DMKU06T MI TT2WR1T DMKU06T MN Cationic trypsinogen (PRSS1) DMKU06T MT DTT DMKU06T MA Inhibitor DMKU06T RN Naphthamidine urokinase plasminogen activator inhibitors with improved pharmacokinetic properties. Bioorg Med Chem Lett. 2005 Jan 3;15(1):93-8. DMKU06T RU https://pubmed.ncbi.nlm.nih.gov/15582418 DMMQ79W DI DMMQ79W DMMQ79W DN 8-Bromo-9-(2,3-dihydroxypropyl)-9H-adenine DMMQ79W MI TTK25J1 DMMQ79W MN Adenosine A1 receptor (ADORA1) DMMQ79W MT DTT DMMQ79W MA Inhibitor DMMQ79W RN 8-Bromo-9-alkyl adenine derivatives as tools for developing new adenosine A2A and A2B receptors ligands. Bioorg Med Chem. 2009 Apr 1;17(7):2812-22. DMMQ79W RU https://pubmed.ncbi.nlm.nih.gov/19282184 DMMQ79W DI DMMQ79W DMMQ79W DN 8-Bromo-9-(2,3-dihydroxypropyl)-9H-adenine DMMQ79W MI TTM2AOE DMMQ79W MN Adenosine A2a receptor (ADORA2A) DMMQ79W MT DTT DMMQ79W MA Inhibitor DMMQ79W RN 8-Bromo-9-alkyl adenine derivatives as tools for developing new adenosine A2A and A2B receptors ligands. Bioorg Med Chem. 2009 Apr 1;17(7):2812-22. DMMQ79W RU https://pubmed.ncbi.nlm.nih.gov/19282184 DMMQ79W DI DMMQ79W DMMQ79W DN 8-Bromo-9-(2,3-dihydroxypropyl)-9H-adenine DMMQ79W MI TTNE7KG DMMQ79W MN Adenosine A2b receptor (ADORA2B) DMMQ79W MT DTT DMMQ79W MA Inhibitor DMMQ79W RN 8-Bromo-9-alkyl adenine derivatives as tools for developing new adenosine A2A and A2B receptors ligands. Bioorg Med Chem. 2009 Apr 1;17(7):2812-22. DMMQ79W RU https://pubmed.ncbi.nlm.nih.gov/19282184 DM5DCPF DI DM5DCPF DM5DCPF DN 8-Bromo-9-(2-butyl)-9H-adenine DM5DCPF MI TTK25J1 DM5DCPF MN Adenosine A1 receptor (ADORA1) DM5DCPF MT DTT DM5DCPF MA Inhibitor DM5DCPF RN 8-Bromo-9-alkyl adenine derivatives as tools for developing new adenosine A2A and A2B receptors ligands. Bioorg Med Chem. 2009 Apr 1;17(7):2812-22. DM5DCPF RU https://pubmed.ncbi.nlm.nih.gov/19282184 DM5DCPF DI DM5DCPF DM5DCPF DN 8-Bromo-9-(2-butyl)-9H-adenine DM5DCPF MI TTM2AOE DM5DCPF MN Adenosine A2a receptor (ADORA2A) DM5DCPF MT DTT DM5DCPF MA Inhibitor DM5DCPF RN 8-Bromo-9-alkyl adenine derivatives as tools for developing new adenosine A2A and A2B receptors ligands. Bioorg Med Chem. 2009 Apr 1;17(7):2812-22. DM5DCPF RU https://pubmed.ncbi.nlm.nih.gov/19282184 DM5DCPF DI DM5DCPF DM5DCPF DN 8-Bromo-9-(2-butyl)-9H-adenine DM5DCPF MI TTNE7KG DM5DCPF MN Adenosine A2b receptor (ADORA2B) DM5DCPF MT DTT DM5DCPF MA Inhibitor DM5DCPF RN 8-Bromo-9-alkyl adenine derivatives as tools for developing new adenosine A2A and A2B receptors ligands. Bioorg Med Chem. 2009 Apr 1;17(7):2812-22. DM5DCPF RU https://pubmed.ncbi.nlm.nih.gov/19282184 DMKW2PE DI DMKW2PE DMKW2PE DN 8-Bromo-9-(2-hydroxypropyl)-9H-adenine DMKW2PE MI TTK25J1 DMKW2PE MN Adenosine A1 receptor (ADORA1) DMKW2PE MT DTT DMKW2PE MA Inhibitor DMKW2PE RN 8-Bromo-9-alkyl adenine derivatives as tools for developing new adenosine A2A and A2B receptors ligands. Bioorg Med Chem. 2009 Apr 1;17(7):2812-22. DMKW2PE RU https://pubmed.ncbi.nlm.nih.gov/19282184 DMKW2PE DI DMKW2PE DMKW2PE DN 8-Bromo-9-(2-hydroxypropyl)-9H-adenine DMKW2PE MI TTM2AOE DMKW2PE MN Adenosine A2a receptor (ADORA2A) DMKW2PE MT DTT DMKW2PE MA Inhibitor DMKW2PE RN 8-Bromo-9-alkyl adenine derivatives as tools for developing new adenosine A2A and A2B receptors ligands. Bioorg Med Chem. 2009 Apr 1;17(7):2812-22. DMKW2PE RU https://pubmed.ncbi.nlm.nih.gov/19282184 DMKW2PE DI DMKW2PE DMKW2PE DN 8-Bromo-9-(2-hydroxypropyl)-9H-adenine DMKW2PE MI TTNE7KG DMKW2PE MN Adenosine A2b receptor (ADORA2B) DMKW2PE MT DTT DMKW2PE MA Inhibitor DMKW2PE RN 8-Bromo-9-alkyl adenine derivatives as tools for developing new adenosine A2A and A2B receptors ligands. Bioorg Med Chem. 2009 Apr 1;17(7):2812-22. DMKW2PE RU https://pubmed.ncbi.nlm.nih.gov/19282184 DMA258T DI DMA258T DMA258T DN 8-Bromo-9-(3-hydroxypropyl)-9H-adenine DMA258T MI TTK25J1 DMA258T MN Adenosine A1 receptor (ADORA1) DMA258T MT DTT DMA258T MA Inhibitor DMA258T RN 8-Bromo-9-alkyl adenine derivatives as tools for developing new adenosine A2A and A2B receptors ligands. Bioorg Med Chem. 2009 Apr 1;17(7):2812-22. DMA258T RU https://pubmed.ncbi.nlm.nih.gov/19282184 DMA258T DI DMA258T DMA258T DN 8-Bromo-9-(3-hydroxypropyl)-9H-adenine DMA258T MI TTM2AOE DMA258T MN Adenosine A2a receptor (ADORA2A) DMA258T MT DTT DMA258T MA Inhibitor DMA258T RN 8-Bromo-9-alkyl adenine derivatives as tools for developing new adenosine A2A and A2B receptors ligands. Bioorg Med Chem. 2009 Apr 1;17(7):2812-22. DMA258T RU https://pubmed.ncbi.nlm.nih.gov/19282184 DMA258T DI DMA258T DMA258T DN 8-Bromo-9-(3-hydroxypropyl)-9H-adenine DMA258T MI TTNE7KG DMA258T MN Adenosine A2b receptor (ADORA2B) DMA258T MT DTT DMA258T MA Inhibitor DMA258T RN 8-Bromo-9-alkyl adenine derivatives as tools for developing new adenosine A2A and A2B receptors ligands. Bioorg Med Chem. 2009 Apr 1;17(7):2812-22. DMA258T RU https://pubmed.ncbi.nlm.nih.gov/19282184 DMA258T DI DMA258T DMA258T DN 8-Bromo-9-(3-hydroxypropyl)-9H-adenine DMA258T MI TTJFY5U DMA258T MN Adenosine A3 receptor (ADORA3) DMA258T MT DTT DMA258T MA Inhibitor DMA258T RN 8-Bromo-9-alkyl adenine derivatives as tools for developing new adenosine A2A and A2B receptors ligands. Bioorg Med Chem. 2009 Apr 1;17(7):2812-22. DMA258T RU https://pubmed.ncbi.nlm.nih.gov/19282184 DMXNF3V DI DMXNF3V DMXNF3V DN 8-Bromo-9-(but-3-enyl)-9H-adenine DMXNF3V MI TTK25J1 DMXNF3V MN Adenosine A1 receptor (ADORA1) DMXNF3V MT DTT DMXNF3V MA Inhibitor DMXNF3V RN 8-Bromo-9-alkyl adenine derivatives as tools for developing new adenosine A2A and A2B receptors ligands. Bioorg Med Chem. 2009 Apr 1;17(7):2812-22. DMXNF3V RU https://pubmed.ncbi.nlm.nih.gov/19282184 DMXNF3V DI DMXNF3V DMXNF3V DN 8-Bromo-9-(but-3-enyl)-9H-adenine DMXNF3V MI TTM2AOE DMXNF3V MN Adenosine A2a receptor (ADORA2A) DMXNF3V MT DTT DMXNF3V MA Inhibitor DMXNF3V RN 8-Bromo-9-alkyl adenine derivatives as tools for developing new adenosine A2A and A2B receptors ligands. Bioorg Med Chem. 2009 Apr 1;17(7):2812-22. DMXNF3V RU https://pubmed.ncbi.nlm.nih.gov/19282184 DMSQPFM DI DMSQPFM DMSQPFM DN 8-Bromo-9-(sec-butyl)-9H-adenine DMSQPFM MI TTK25J1 DMSQPFM MN Adenosine A1 receptor (ADORA1) DMSQPFM MT DTT DMSQPFM MA Inhibitor DMSQPFM RN 8-Bromo-9-alkyl adenine derivatives as tools for developing new adenosine A2A and A2B receptors ligands. Bioorg Med Chem. 2009 Apr 1;17(7):2812-22. DMSQPFM RU https://pubmed.ncbi.nlm.nih.gov/19282184 DMSQPFM DI DMSQPFM DMSQPFM DN 8-Bromo-9-(sec-butyl)-9H-adenine DMSQPFM MI TTM2AOE DMSQPFM MN Adenosine A2a receptor (ADORA2A) DMSQPFM MT DTT DMSQPFM MA Inhibitor DMSQPFM RN 8-Bromo-9-alkyl adenine derivatives as tools for developing new adenosine A2A and A2B receptors ligands. Bioorg Med Chem. 2009 Apr 1;17(7):2812-22. DMSQPFM RU https://pubmed.ncbi.nlm.nih.gov/19282184 DMSQPFM DI DMSQPFM DMSQPFM DN 8-Bromo-9-(sec-butyl)-9H-adenine DMSQPFM MI TTNE7KG DMSQPFM MN Adenosine A2b receptor (ADORA2B) DMSQPFM MT DTT DMSQPFM MA Inhibitor DMSQPFM RN 8-Bromo-9-alkyl adenine derivatives as tools for developing new adenosine A2A and A2B receptors ligands. Bioorg Med Chem. 2009 Apr 1;17(7):2812-22. DMSQPFM RU https://pubmed.ncbi.nlm.nih.gov/19282184 DMSQPFM DI DMSQPFM DMSQPFM DN 8-Bromo-9-(sec-butyl)-9H-adenine DMSQPFM MI TTJFY5U DMSQPFM MN Adenosine A3 receptor (ADORA3) DMSQPFM MT DTT DMSQPFM MA Inhibitor DMSQPFM RN 8-Bromo-9-alkyl adenine derivatives as tools for developing new adenosine A2A and A2B receptors ligands. Bioorg Med Chem. 2009 Apr 1;17(7):2812-22. DMSQPFM RU https://pubmed.ncbi.nlm.nih.gov/19282184 DMUTV76 DI DMUTV76 DMUTV76 DN 8-Bromo-9-cyclobutyl-9H-adenine DMUTV76 MI TTK25J1 DMUTV76 MN Adenosine A1 receptor (ADORA1) DMUTV76 MT DTT DMUTV76 MA Inhibitor DMUTV76 RN 8-Bromo-9-alkyl adenine derivatives as tools for developing new adenosine A2A and A2B receptors ligands. Bioorg Med Chem. 2009 Apr 1;17(7):2812-22. DMUTV76 RU https://pubmed.ncbi.nlm.nih.gov/19282184 DMUTV76 DI DMUTV76 DMUTV76 DN 8-Bromo-9-cyclobutyl-9H-adenine DMUTV76 MI TTM2AOE DMUTV76 MN Adenosine A2a receptor (ADORA2A) DMUTV76 MT DTT DMUTV76 MA Inhibitor DMUTV76 RN 8-Bromo-9-alkyl adenine derivatives as tools for developing new adenosine A2A and A2B receptors ligands. Bioorg Med Chem. 2009 Apr 1;17(7):2812-22. DMUTV76 RU https://pubmed.ncbi.nlm.nih.gov/19282184 DMUTV76 DI DMUTV76 DMUTV76 DN 8-Bromo-9-cyclobutyl-9H-adenine DMUTV76 MI TTNE7KG DMUTV76 MN Adenosine A2b receptor (ADORA2B) DMUTV76 MT DTT DMUTV76 MA Inhibitor DMUTV76 RN 8-Bromo-9-alkyl adenine derivatives as tools for developing new adenosine A2A and A2B receptors ligands. Bioorg Med Chem. 2009 Apr 1;17(7):2812-22. DMUTV76 RU https://pubmed.ncbi.nlm.nih.gov/19282184 DMUTV76 DI DMUTV76 DMUTV76 DN 8-Bromo-9-cyclobutyl-9H-adenine DMUTV76 MI TTJFY5U DMUTV76 MN Adenosine A3 receptor (ADORA3) DMUTV76 MT DTT DMUTV76 MA Inhibitor DMUTV76 RN 8-Bromo-9-alkyl adenine derivatives as tools for developing new adenosine A2A and A2B receptors ligands. Bioorg Med Chem. 2009 Apr 1;17(7):2812-22. DMUTV76 RU https://pubmed.ncbi.nlm.nih.gov/19282184 DMLVCON DI DMLVCON DMLVCON DN 8-Bromo-9-cyclohexyl-9H-adenine DMLVCON MI TTK25J1 DMLVCON MN Adenosine A1 receptor (ADORA1) DMLVCON MT DTT DMLVCON MA Inhibitor DMLVCON RN 8-Bromo-9-alkyl adenine derivatives as tools for developing new adenosine A2A and A2B receptors ligands. Bioorg Med Chem. 2009 Apr 1;17(7):2812-22. DMLVCON RU https://pubmed.ncbi.nlm.nih.gov/19282184 DMLVCON DI DMLVCON DMLVCON DN 8-Bromo-9-cyclohexyl-9H-adenine DMLVCON MI TTM2AOE DMLVCON MN Adenosine A2a receptor (ADORA2A) DMLVCON MT DTT DMLVCON MA Inhibitor DMLVCON RN 8-Bromo-9-alkyl adenine derivatives as tools for developing new adenosine A2A and A2B receptors ligands. Bioorg Med Chem. 2009 Apr 1;17(7):2812-22. DMLVCON RU https://pubmed.ncbi.nlm.nih.gov/19282184 DMLVCON DI DMLVCON DMLVCON DN 8-Bromo-9-cyclohexyl-9H-adenine DMLVCON MI TTJFY5U DMLVCON MN Adenosine A3 receptor (ADORA3) DMLVCON MT DTT DMLVCON MA Inhibitor DMLVCON RN 8-Bromo-9-alkyl adenine derivatives as tools for developing new adenosine A2A and A2B receptors ligands. Bioorg Med Chem. 2009 Apr 1;17(7):2812-22. DMLVCON RU https://pubmed.ncbi.nlm.nih.gov/19282184 DMCK0O1 DI DMCK0O1 DMCK0O1 DN 8-Bromo-9-cyclopentyl-9H-adenine DMCK0O1 MI TTK25J1 DMCK0O1 MN Adenosine A1 receptor (ADORA1) DMCK0O1 MT DTT DMCK0O1 MA Inhibitor DMCK0O1 RN 8-Bromo-9-alkyl adenine derivatives as tools for developing new adenosine A2A and A2B receptors ligands. Bioorg Med Chem. 2009 Apr 1;17(7):2812-22. DMCK0O1 RU https://pubmed.ncbi.nlm.nih.gov/19282184 DMCK0O1 DI DMCK0O1 DMCK0O1 DN 8-Bromo-9-cyclopentyl-9H-adenine DMCK0O1 MI TTM2AOE DMCK0O1 MN Adenosine A2a receptor (ADORA2A) DMCK0O1 MT DTT DMCK0O1 MA Inhibitor DMCK0O1 RN 8-Bromo-9-alkyl adenine derivatives as tools for developing new adenosine A2A and A2B receptors ligands. Bioorg Med Chem. 2009 Apr 1;17(7):2812-22. DMCK0O1 RU https://pubmed.ncbi.nlm.nih.gov/19282184 DMCK0O1 DI DMCK0O1 DMCK0O1 DN 8-Bromo-9-cyclopentyl-9H-adenine DMCK0O1 MI TTNE7KG DMCK0O1 MN Adenosine A2b receptor (ADORA2B) DMCK0O1 MT DTT DMCK0O1 MA Inhibitor DMCK0O1 RN 8-Bromo-9-alkyl adenine derivatives as tools for developing new adenosine A2A and A2B receptors ligands. Bioorg Med Chem. 2009 Apr 1;17(7):2812-22. DMCK0O1 RU https://pubmed.ncbi.nlm.nih.gov/19282184 DMCK0O1 DI DMCK0O1 DMCK0O1 DN 8-Bromo-9-cyclopentyl-9H-adenine DMCK0O1 MI TTJFY5U DMCK0O1 MN Adenosine A3 receptor (ADORA3) DMCK0O1 MT DTT DMCK0O1 MA Inhibitor DMCK0O1 RN 8-Bromo-9-alkyl adenine derivatives as tools for developing new adenosine A2A and A2B receptors ligands. Bioorg Med Chem. 2009 Apr 1;17(7):2812-22. DMCK0O1 RU https://pubmed.ncbi.nlm.nih.gov/19282184 DM4YAD6 DI DM4YAD6 DM4YAD6 DN 8-Bromo-9-ethyl-9H-adenine DM4YAD6 MI TTK25J1 DM4YAD6 MN Adenosine A1 receptor (ADORA1) DM4YAD6 MT DTT DM4YAD6 MA Inhibitor DM4YAD6 RN 8-Bromo-9-alkyl adenine derivatives as tools for developing new adenosine A2A and A2B receptors ligands. Bioorg Med Chem. 2009 Apr 1;17(7):2812-22. DM4YAD6 RU https://pubmed.ncbi.nlm.nih.gov/19282184 DM4YAD6 DI DM4YAD6 DM4YAD6 DN 8-Bromo-9-ethyl-9H-adenine DM4YAD6 MI TTM2AOE DM4YAD6 MN Adenosine A2a receptor (ADORA2A) DM4YAD6 MT DTT DM4YAD6 MA Inhibitor DM4YAD6 RN 8-Bromo-9-alkyl adenine derivatives as tools for developing new adenosine A2A and A2B receptors ligands. Bioorg Med Chem. 2009 Apr 1;17(7):2812-22. DM4YAD6 RU https://pubmed.ncbi.nlm.nih.gov/19282184 DM4YAD6 DI DM4YAD6 DM4YAD6 DN 8-Bromo-9-ethyl-9H-adenine DM4YAD6 MI TTNE7KG DM4YAD6 MN Adenosine A2b receptor (ADORA2B) DM4YAD6 MT DTT DM4YAD6 MA Inhibitor DM4YAD6 RN 8-Bromo-9-alkyl adenine derivatives as tools for developing new adenosine A2A and A2B receptors ligands. Bioorg Med Chem. 2009 Apr 1;17(7):2812-22. DM4YAD6 RU https://pubmed.ncbi.nlm.nih.gov/19282184 DMZF3UN DI DMZF3UN DMZF3UN DN 8-bromo-9-isobutyl-9H-purin-6-amine DMZF3UN MI TTK25J1 DMZF3UN MN Adenosine A1 receptor (ADORA1) DMZF3UN MT DTT DMZF3UN MA Inhibitor DMZF3UN RN Insights into binding modes of adenosine A(2B) antagonists with ligand-based and receptor-based methods. Eur J Med Chem. 2010 Aug;45(8):3459-71. DMZF3UN RU https://pubmed.ncbi.nlm.nih.gov/20537438 DMZF3UN DI DMZF3UN DMZF3UN DN 8-bromo-9-isobutyl-9H-purin-6-amine DMZF3UN MI TTM2AOE DMZF3UN MN Adenosine A2a receptor (ADORA2A) DMZF3UN MT DTT DMZF3UN MA Inhibitor DMZF3UN RN Insights into binding modes of adenosine A(2B) antagonists with ligand-based and receptor-based methods. Eur J Med Chem. 2010 Aug;45(8):3459-71. DMZF3UN RU https://pubmed.ncbi.nlm.nih.gov/20537438 DMZF3UN DI DMZF3UN DMZF3UN DN 8-bromo-9-isobutyl-9H-purin-6-amine DMZF3UN MI TTNE7KG DMZF3UN MN Adenosine A2b receptor (ADORA2B) DMZF3UN MT DTT DMZF3UN MA Inhibitor DMZF3UN RN Insights into binding modes of adenosine A(2B) antagonists with ligand-based and receptor-based methods. Eur J Med Chem. 2010 Aug;45(8):3459-71. DMZF3UN RU https://pubmed.ncbi.nlm.nih.gov/20537438 DMZF3UN DI DMZF3UN DMZF3UN DN 8-bromo-9-isobutyl-9H-purin-6-amine DMZF3UN MI TTJFY5U DMZF3UN MN Adenosine A3 receptor (ADORA3) DMZF3UN MT DTT DMZF3UN MA Inhibitor DMZF3UN RN Insights into binding modes of adenosine A(2B) antagonists with ligand-based and receptor-based methods. Eur J Med Chem. 2010 Aug;45(8):3459-71. DMZF3UN RU https://pubmed.ncbi.nlm.nih.gov/20537438 DMIN9HC DI DMIN9HC DMIN9HC DN 8-Bromo-9-isopropyl-9H-adenine DMIN9HC MI TTK25J1 DMIN9HC MN Adenosine A1 receptor (ADORA1) DMIN9HC MT DTT DMIN9HC MA Inhibitor DMIN9HC RN 8-Bromo-9-alkyl adenine derivatives as tools for developing new adenosine A2A and A2B receptors ligands. Bioorg Med Chem. 2009 Apr 1;17(7):2812-22. DMIN9HC RU https://pubmed.ncbi.nlm.nih.gov/19282184 DMIN9HC DI DMIN9HC DMIN9HC DN 8-Bromo-9-isopropyl-9H-adenine DMIN9HC MI TTM2AOE DMIN9HC MN Adenosine A2a receptor (ADORA2A) DMIN9HC MT DTT DMIN9HC MA Inhibitor DMIN9HC RN 8-Bromo-9-alkyl adenine derivatives as tools for developing new adenosine A2A and A2B receptors ligands. Bioorg Med Chem. 2009 Apr 1;17(7):2812-22. DMIN9HC RU https://pubmed.ncbi.nlm.nih.gov/19282184 DMIN9HC DI DMIN9HC DMIN9HC DN 8-Bromo-9-isopropyl-9H-adenine DMIN9HC MI TTNE7KG DMIN9HC MN Adenosine A2b receptor (ADORA2B) DMIN9HC MT DTT DMIN9HC MA Inhibitor DMIN9HC RN 8-Bromo-9-alkyl adenine derivatives as tools for developing new adenosine A2A and A2B receptors ligands. Bioorg Med Chem. 2009 Apr 1;17(7):2812-22. DMIN9HC RU https://pubmed.ncbi.nlm.nih.gov/19282184 DMIN9HC DI DMIN9HC DMIN9HC DN 8-Bromo-9-isopropyl-9H-adenine DMIN9HC MI TTJFY5U DMIN9HC MN Adenosine A3 receptor (ADORA3) DMIN9HC MT DTT DMIN9HC MA Inhibitor DMIN9HC RN 8-Bromo-9-alkyl adenine derivatives as tools for developing new adenosine A2A and A2B receptors ligands. Bioorg Med Chem. 2009 Apr 1;17(7):2812-22. DMIN9HC RU https://pubmed.ncbi.nlm.nih.gov/19282184 DM1DS3B DI DM1DS3B DM1DS3B DN 8-Bromo-9-methyl-9H-adenine DM1DS3B MI TTK25J1 DM1DS3B MN Adenosine A1 receptor (ADORA1) DM1DS3B MT DTT DM1DS3B MA Inhibitor DM1DS3B RN 8-Bromo-9-alkyl adenine derivatives as tools for developing new adenosine A2A and A2B receptors ligands. Bioorg Med Chem. 2009 Apr 1;17(7):2812-22. DM1DS3B RU https://pubmed.ncbi.nlm.nih.gov/19282184 DM1DS3B DI DM1DS3B DM1DS3B DN 8-Bromo-9-methyl-9H-adenine DM1DS3B MI TTM2AOE DM1DS3B MN Adenosine A2a receptor (ADORA2A) DM1DS3B MT DTT DM1DS3B MA Inhibitor DM1DS3B RN 8-Bromo-9-alkyl adenine derivatives as tools for developing new adenosine A2A and A2B receptors ligands. Bioorg Med Chem. 2009 Apr 1;17(7):2812-22. DM1DS3B RU https://pubmed.ncbi.nlm.nih.gov/19282184 DM1DS3B DI DM1DS3B DM1DS3B DN 8-Bromo-9-methyl-9H-adenine DM1DS3B MI TTNE7KG DM1DS3B MN Adenosine A2b receptor (ADORA2B) DM1DS3B MT DTT DM1DS3B MA Inhibitor DM1DS3B RN 8-Bromo-9-alkyl adenine derivatives as tools for developing new adenosine A2A and A2B receptors ligands. Bioorg Med Chem. 2009 Apr 1;17(7):2812-22. DM1DS3B RU https://pubmed.ncbi.nlm.nih.gov/19282184 DMB7EWZ DI DMB7EWZ DMB7EWZ DN 8-Bromo-9-phenylethyl-9H-adenine DMB7EWZ MI TTK25J1 DMB7EWZ MN Adenosine A1 receptor (ADORA1) DMB7EWZ MT DTT DMB7EWZ MA Inhibitor DMB7EWZ RN 8-Bromo-9-alkyl adenine derivatives as tools for developing new adenosine A2A and A2B receptors ligands. Bioorg Med Chem. 2009 Apr 1;17(7):2812-22. DMB7EWZ RU https://pubmed.ncbi.nlm.nih.gov/19282184 DMB7EWZ DI DMB7EWZ DMB7EWZ DN 8-Bromo-9-phenylethyl-9H-adenine DMB7EWZ MI TTM2AOE DMB7EWZ MN Adenosine A2a receptor (ADORA2A) DMB7EWZ MT DTT DMB7EWZ MA Inhibitor DMB7EWZ RN 8-Bromo-9-alkyl adenine derivatives as tools for developing new adenosine A2A and A2B receptors ligands. Bioorg Med Chem. 2009 Apr 1;17(7):2812-22. DMB7EWZ RU https://pubmed.ncbi.nlm.nih.gov/19282184 DMRIPU5 DI DMRIPU5 DMRIPU5 DN 8-Bromo-9-propyl-9H-adenine DMRIPU5 MI TTK25J1 DMRIPU5 MN Adenosine A1 receptor (ADORA1) DMRIPU5 MT DTT DMRIPU5 MA Inhibitor DMRIPU5 RN 8-Bromo-9-alkyl adenine derivatives as tools for developing new adenosine A2A and A2B receptors ligands. Bioorg Med Chem. 2009 Apr 1;17(7):2812-22. DMRIPU5 RU https://pubmed.ncbi.nlm.nih.gov/19282184 DMRIPU5 DI DMRIPU5 DMRIPU5 DN 8-Bromo-9-propyl-9H-adenine DMRIPU5 MI TTM2AOE DMRIPU5 MN Adenosine A2a receptor (ADORA2A) DMRIPU5 MT DTT DMRIPU5 MA Inhibitor DMRIPU5 RN 8-Bromo-9-alkyl adenine derivatives as tools for developing new adenosine A2A and A2B receptors ligands. Bioorg Med Chem. 2009 Apr 1;17(7):2812-22. DMRIPU5 RU https://pubmed.ncbi.nlm.nih.gov/19282184 DMRIPU5 DI DMRIPU5 DMRIPU5 DN 8-Bromo-9-propyl-9H-adenine DMRIPU5 MI TTNE7KG DMRIPU5 MN Adenosine A2b receptor (ADORA2B) DMRIPU5 MT DTT DMRIPU5 MA Inhibitor DMRIPU5 RN 8-Bromo-9-alkyl adenine derivatives as tools for developing new adenosine A2A and A2B receptors ligands. Bioorg Med Chem. 2009 Apr 1;17(7):2812-22. DMRIPU5 RU https://pubmed.ncbi.nlm.nih.gov/19282184 DM4CV1E DI DM4CV1E DM4CV1E DN 8-Bromo-Adenosine-5'-Monophosphate DM4CV1E MI TTVIAT9 DM4CV1E MN Phosphodiesterase 4B (PDE4B) DM4CV1E MT DTT DM4CV1E MA Inhibitor DM4CV1E RN DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Nucleic Acids Res. 2011 Jan;39(Database issue):D1035-41. DM4CV1E RU https://pubmed.ncbi.nlm.nih.gov/21059682 DM5RFCN DI DM5RFCN DM5RFCN DN 8-Butoxy-quinolin-2-ylamine DM5RFCN MI TTX4RTB DM5RFCN MN Melanin-concentrating hormone receptor 1 (MCHR1) DM5RFCN MT DTT DM5RFCN MA Inhibitor DM5RFCN RN Synthesis and evaluation of 2-amino-8-alkoxy quinolines as MCHr1 antagonists. Part 1. Bioorg Med Chem Lett. 2004 Oct 4;14(19):4873-7. DM5RFCN RU https://pubmed.ncbi.nlm.nih.gov/15341942 DMD18V5 DI DMD18V5 DMD18V5 DN 8-carboxamidocyclazocine DMD18V5 MI TT27RFC DMD18V5 MN Opioid receptor delta (OPRD1) DMD18V5 MT DTT DMD18V5 MA Inhibitor DMD18V5 RN Redefining the structure-activity relationships of 2,6-methano-3-benzazocines. Part 6: Opioid receptor binding properties of cyclic variants of 8-c... Bioorg Med Chem. 2008 May 15;16(10):5653-64. DMD18V5 RU https://pubmed.ncbi.nlm.nih.gov/18417347 DMD18V5 DI DMD18V5 DMD18V5 DN 8-carboxamidocyclazocine DMD18V5 MI TTQW87Y DMD18V5 MN Opioid receptor kappa (OPRK1) DMD18V5 MT DTT DMD18V5 MA Inhibitor DMD18V5 RN Redefining the structure-activity relationships of 2,6-methano-3-benzazocines. Part 6: Opioid receptor binding properties of cyclic variants of 8-c... Bioorg Med Chem. 2008 May 15;16(10):5653-64. DMD18V5 RU https://pubmed.ncbi.nlm.nih.gov/18417347 DMD18V5 DI DMD18V5 DMD18V5 DN 8-carboxamidocyclazocine DMD18V5 MI TTKWM86 DMD18V5 MN Opioid receptor mu (MOP) DMD18V5 MT DTT DMD18V5 MA Inhibitor DMD18V5 RN Redefining the structure-activity relationships of 2,6-methano-3-benzazocines. Part 6: Opioid receptor binding properties of cyclic variants of 8-c... Bioorg Med Chem. 2008 May 15;16(10):5653-64. DMD18V5 RU https://pubmed.ncbi.nlm.nih.gov/18417347 DMS7DA3 DI DMS7DA3 DMS7DA3 DN 8-Chloro-1,2,3,4-tetrahydro-acridin-9-ylamine DMS7DA3 MI TT1RS9F DMS7DA3 MN Acetylcholinesterase (AChE) DMS7DA3 MT DTT DMS7DA3 MA Inhibitor DMS7DA3 RN The synthesis and in vitro acetylcholinesterase and butyrylcholinesterase inhibitory activity of tacrine (Cognex ) derivaties, Bioorg. Med. Chem. Lett. 2(8):861-864 (1992). DMS7DA3 RU http://www.sciencedirect.com/science/article/pii/S0960894X00805454 DMFW6Q0 DI DMFW6Q0 DMFW6Q0 DN 8-Chloro-1,2,3,4-tetrahydro-pyrazino[1,2-a]indole DMFW6Q0 MI TTJQOD7 DMFW6Q0 MN 5-HT 2A receptor (HTR2A) DMFW6Q0 MT DTT DMFW6Q0 MA Inhibitor DMFW6Q0 RN Evaluation of isotryptamine derivatives at 5-HT(2) serotonin receptors. Bioorg Med Chem Lett. 2002 Jan 21;12(2):155-8. DMFW6Q0 RU https://pubmed.ncbi.nlm.nih.gov/11755343 DM5IGOL DI DM5IGOL DM5IGOL DN 8-Chloro-1,3-dihydro-imidazo[4,5-b]quinolin-2-one DM5IGOL MI TT06AWU DM5IGOL MN Phosphodiesterase 3A (PDE3A) DM5IGOL MT DTT DM5IGOL MA Inhibitor DM5IGOL RN 1,3-Dihydro-2H-imidazo[4,5-b]quinolin-2-ones--inhibitors of blood platelet cAMP phosphodiesterase and induced aggregation. J Med Chem. 1991 Sep;34(9):2906-16. DM5IGOL RU https://pubmed.ncbi.nlm.nih.gov/1654430 DM61VJO DI DM61VJO DM61VJO DN 8-chloro-3,4-dihydroquinazolin-2-amine DM61VJO MI TTRUFDT DM61VJO MN 5-HT 5A receptor (HTR5A) DM61VJO MT DTT DM61VJO MA Inhibitor DM61VJO RN Cyclic guanidines as dual 5-HT5A/5-HT7 receptor ligands: structure-activity relationship elucidation. Bioorg Med Chem Lett. 2008 Jan 1;18(1):256-61. DM61VJO RU https://pubmed.ncbi.nlm.nih.gov/17998160 DM842L6 DI DM842L6 DM842L6 DN 8-Chloro-3-hydroxy-1H-benzo[b]azepine-2,5-dione DM842L6 MI TTLD29N DM842L6 MN Glutamate receptor ionotropic NMDA 1 (NMDAR1) DM842L6 MT DTT DM842L6 MA Inhibitor DM842L6 RN Analogs of 3-hydroxy-1H-1-benzazepine-2,5-dione: structure-activity relationship at N-methyl-D-aspartate receptor glycine sites. J Med Chem. 1996 Nov 8;39(23):4643-53. DM842L6 RU https://pubmed.ncbi.nlm.nih.gov/8917653 DM842L6 DI DM842L6 DM842L6 DN 8-Chloro-3-hydroxy-1H-benzo[b]azepine-2,5-dione DM842L6 MI TTKJEMQ DM842L6 MN Glutamate receptor ionotropic NMDA 2A (NMDAR2A) DM842L6 MT DTT DM842L6 MA Inhibitor DM842L6 RN Analogs of 3-hydroxy-1H-1-benzazepine-2,5-dione: structure-activity relationship at N-methyl-D-aspartate receptor glycine sites. J Med Chem. 1996 Nov 8;39(23):4643-53. DM842L6 RU https://pubmed.ncbi.nlm.nih.gov/8917653 DM842L6 DI DM842L6 DM842L6 DN 8-Chloro-3-hydroxy-1H-benzo[b]azepine-2,5-dione DM842L6 MI TTN9D8E DM842L6 MN Glutamate receptor ionotropic NMDA 2B (NMDAR2B) DM842L6 MT DTT DM842L6 MA Inhibitor DM842L6 RN Analogs of 3-hydroxy-1H-1-benzazepine-2,5-dione: structure-activity relationship at N-methyl-D-aspartate receptor glycine sites. J Med Chem. 1996 Nov 8;39(23):4643-53. DM842L6 RU https://pubmed.ncbi.nlm.nih.gov/8917653 DMB76ZN DI DMB76ZN DMB76ZN DN 8-Chloro-6-(4-hydroxy-phenyl)-naphthalen-2-ol DMB76ZN MI TTZAYWL DMB76ZN MN Estrogen receptor (ESR) DMB76ZN MT DTT DMB76ZN MA Inhibitor DMB76ZN RN ERbeta ligands. 3. Exploiting two binding orientations of the 2-phenylnaphthalene scaffold to achieve ERbeta selectivity. J Med Chem. 2005 Jun 16;48(12):3953-79. DMB76ZN RU https://pubmed.ncbi.nlm.nih.gov/15943471 DMB76ZN DI DMB76ZN DMB76ZN DN 8-Chloro-6-(4-hydroxy-phenyl)-naphthalen-2-ol DMB76ZN MI TTOM3J0 DMB76ZN MN Estrogen receptor beta (ESR2) DMB76ZN MT DTT DMB76ZN MA Inhibitor DMB76ZN RN ERbeta ligands. 3. Exploiting two binding orientations of the 2-phenylnaphthalene scaffold to achieve ERbeta selectivity. J Med Chem. 2005 Jun 16;48(12):3953-79. DMB76ZN RU https://pubmed.ncbi.nlm.nih.gov/15943471 DMFNUHQ DI DMFNUHQ DMFNUHQ DN 8-chloro-quinoline-3-carbonitrile DMFNUHQ MI TTGECUM DMFNUHQ MN Cot oncogene messenger RNA (MAP3K8 mRNA) DMFNUHQ MT DTT DMFNUHQ MA Inhibitor DMFNUHQ RN Pharmacologic inhibition of tpl2 blocks inflammatory responses in primary human monocytes, synoviocytes, and blood. J Biol Chem. 2007 Nov 16;282(46):33295-304. DMFNUHQ RU https://pubmed.ncbi.nlm.nih.gov/17848581 DMFNUHQ DI DMFNUHQ DMFNUHQ DN 8-chloro-quinoline-3-carbonitrile DMFNUHQ MI TTUZ2L5 DMFNUHQ MN Matrix metalloproteinase-3 (MMP-3) DMFNUHQ MT DTT DMFNUHQ MA Inhibitor DMFNUHQ RN Pharmacologic inhibition of tpl2 blocks inflammatory responses in primary human monocytes, synoviocytes, and blood. J Biol Chem. 2007 Nov 16;282(46):33295-304. DMFNUHQ RU https://pubmed.ncbi.nlm.nih.gov/17848581 DM4VTM2 DI DM4VTM2 DM4VTM2 DN 8-Cyclobutylmethoxy-quinolin-2-ylamine DM4VTM2 MI TTX4RTB DM4VTM2 MN Melanin-concentrating hormone receptor 1 (MCHR1) DM4VTM2 MT DTT DM4VTM2 MA Inhibitor DM4VTM2 RN Synthesis and evaluation of 2-amino-8-alkoxy quinolines as MCHr1 antagonists. Part 1. Bioorg Med Chem Lett. 2004 Oct 4;14(19):4873-7. DM4VTM2 RU https://pubmed.ncbi.nlm.nih.gov/15341942 DMEBYRW DI DMEBYRW DMEBYRW DN 8-Cycloheptyloxy-quinolin-2-ylamine DMEBYRW MI TTX4RTB DMEBYRW MN Melanin-concentrating hormone receptor 1 (MCHR1) DMEBYRW MT DTT DMEBYRW MA Inhibitor DMEBYRW RN Synthesis and evaluation of 2-amino-8-alkoxy quinolines as MCHr1 antagonists. Part 1. Bioorg Med Chem Lett. 2004 Oct 4;14(19):4873-7. DMEBYRW RU https://pubmed.ncbi.nlm.nih.gov/15341942 DM79VQM DI DM79VQM DM79VQM DN 8-cyclohexyl-6-(4-tolyl)-2-phenyl-9H-purine DM79VQM MI TTK25J1 DM79VQM MN Adenosine A1 receptor (ADORA1) DM79VQM MT DTT DM79VQM MA Inhibitor DM79VQM RN 2,6-disubstituted and 2,6,8-trisubstituted purines as adenosine receptor antagonists. J Med Chem. 2006 May 18;49(10):2861-7. DM79VQM RU https://pubmed.ncbi.nlm.nih.gov/16686529 DMKT0YQ DI DMKT0YQ DMKT0YQ DN 8-Cyclohexyloxy-quinolin-2-ylamine DMKT0YQ MI TTX4RTB DMKT0YQ MN Melanin-concentrating hormone receptor 1 (MCHR1) DMKT0YQ MT DTT DMKT0YQ MA Inhibitor DMKT0YQ RN Synthesis and evaluation of 2-amino-8-alkoxy quinolines as MCHr1 antagonists. Part 1. Bioorg Med Chem Lett. 2004 Oct 4;14(19):4873-7. DMKT0YQ RU https://pubmed.ncbi.nlm.nih.gov/15341942 DM16KZS DI DM16KZS DM16KZS DN 8-Cyclopentylmethoxy-quinolin-2-ylamine DM16KZS MI TTX4RTB DM16KZS MN Melanin-concentrating hormone receptor 1 (MCHR1) DM16KZS MT DTT DM16KZS MA Inhibitor DM16KZS RN Synthesis and evaluation of 2-amino-8-alkoxy quinolines as MCHr1 antagonists. Part 1. Bioorg Med Chem Lett. 2004 Oct 4;14(19):4873-7. DM16KZS RU https://pubmed.ncbi.nlm.nih.gov/15341942 DMMITAJ DI DMMITAJ DMMITAJ DN 8-cyclopentyltheophylline DMMITAJ MI TTK25J1 DMMITAJ MN Adenosine A1 receptor (ADORA1) DMMITAJ MT DTT DMMITAJ MA Antagonist DMMITAJ RN Thermodynamics of full agonist, partial agonist, and antagonist binding to wild-type and mutant adenosine A1 receptors. Biochem Pharmacol. 1998 Dec 1;56(11):1437-45. DMMITAJ RU https://pubmed.ncbi.nlm.nih.gov/9827575 DMEOP4J DI DMEOP4J DMEOP4J DN 8-DEOXYGARTANIN DMEOP4J MI TT50QJ3 DMEOP4J MN Influenza Neuraminidase (Influ NA) DMEOP4J MT DTT DMEOP4J MA Inhibitor DMEOP4J RN Xanthones with neuraminidase inhibitory activity from the seedcases of Garcinia mangostana. Bioorg Med Chem. 2010 Sep 1;18(17):6258-64. DMEOP4J RU https://pubmed.ncbi.nlm.nih.gov/20696581 DM7YW3B DI DM7YW3B DM7YW3B DN 8-deoxy-neodysiherbaine DM7YW3B MI TT0MYE2 DM7YW3B MN Glutamate receptor ionotropic kainate 1 (GRIK1) DM7YW3B MT DTT DM7YW3B MA Agonist DM7YW3B RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 450). DM7YW3B RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=450 DMQJA4F DI DMQJA4F DMQJA4F DN 8-Diazonium-naphthalene-1-sulfonic acid anion DMQJA4F MI TTNJYV2 DMQJA4F MN Gamma-aminobutyric acid receptor (GAR) DMQJA4F MT DTT DMQJA4F MA Inhibitor DMQJA4F RN Aryl diazo compounds and diazonium salts as potential irreversible probes of the gamma-aminobutyric acid receptor. J Med Chem. 1987 Dec;30(12):2222-7. DMQJA4F RU https://pubmed.ncbi.nlm.nih.gov/2824775 DMUR97N DI DMUR97N DMUR97N DN 8-dibenzofuran-4-yl-2-morpholin-4-ylchromen-4-one DMUR97N MI TTK3PY9 DMUR97N MN DNA-dependent protein kinase catalytic (PRKDC) DMUR97N MT DTT DMUR97N MA Inhibitor DMUR97N RN Discovery of potent chromen-4-one inhibitors of the DNA-dependent protein kinase (DNA-PK) using a small-molecule library approach. J Med Chem. 2005 Dec 1;48(24):7829-46. DMUR97N RU https://pubmed.ncbi.nlm.nih.gov/16302822 DMY8W0K DI DMY8W0K DMY8W0K DN 8-Ethyl-3-hydroxy-1H-benzo[b]azepine-2,5-dione DMY8W0K MI TTLD29N DMY8W0K MN Glutamate receptor ionotropic NMDA 1 (NMDAR1) DMY8W0K MT DTT DMY8W0K MA Inhibitor DMY8W0K RN Analogs of 3-hydroxy-1H-1-benzazepine-2,5-dione: structure-activity relationship at N-methyl-D-aspartate receptor glycine sites. J Med Chem. 1996 Nov 8;39(23):4643-53. DMY8W0K RU https://pubmed.ncbi.nlm.nih.gov/8917653 DMY8W0K DI DMY8W0K DMY8W0K DN 8-Ethyl-3-hydroxy-1H-benzo[b]azepine-2,5-dione DMY8W0K MI TTKJEMQ DMY8W0K MN Glutamate receptor ionotropic NMDA 2A (NMDAR2A) DMY8W0K MT DTT DMY8W0K MA Inhibitor DMY8W0K RN Analogs of 3-hydroxy-1H-1-benzazepine-2,5-dione: structure-activity relationship at N-methyl-D-aspartate receptor glycine sites. J Med Chem. 1996 Nov 8;39(23):4643-53. DMY8W0K RU https://pubmed.ncbi.nlm.nih.gov/8917653 DMY8W0K DI DMY8W0K DMY8W0K DN 8-Ethyl-3-hydroxy-1H-benzo[b]azepine-2,5-dione DMY8W0K MI TTN9D8E DMY8W0K MN Glutamate receptor ionotropic NMDA 2B (NMDAR2B) DMY8W0K MT DTT DMY8W0K MA Inhibitor DMY8W0K RN Analogs of 3-hydroxy-1H-1-benzazepine-2,5-dione: structure-activity relationship at N-methyl-D-aspartate receptor glycine sites. J Med Chem. 1996 Nov 8;39(23):4643-53. DMY8W0K RU https://pubmed.ncbi.nlm.nih.gov/8917653 DMBZSAO DI DMBZSAO DMBZSAO DN 8-Fluoro-3-hydroxy-1H-benzo[b]azepine-2,5-dione DMBZSAO MI TTLD29N DMBZSAO MN Glutamate receptor ionotropic NMDA 1 (NMDAR1) DMBZSAO MT DTT DMBZSAO MA Inhibitor DMBZSAO RN Analogs of 3-hydroxy-1H-1-benzazepine-2,5-dione: structure-activity relationship at N-methyl-D-aspartate receptor glycine sites. J Med Chem. 1996 Nov 8;39(23):4643-53. DMBZSAO RU https://pubmed.ncbi.nlm.nih.gov/8917653 DMBZSAO DI DMBZSAO DMBZSAO DN 8-Fluoro-3-hydroxy-1H-benzo[b]azepine-2,5-dione DMBZSAO MI TTKJEMQ DMBZSAO MN Glutamate receptor ionotropic NMDA 2A (NMDAR2A) DMBZSAO MT DTT DMBZSAO MA Inhibitor DMBZSAO RN Analogs of 3-hydroxy-1H-1-benzazepine-2,5-dione: structure-activity relationship at N-methyl-D-aspartate receptor glycine sites. J Med Chem. 1996 Nov 8;39(23):4643-53. DMBZSAO RU https://pubmed.ncbi.nlm.nih.gov/8917653 DMBZSAO DI DMBZSAO DMBZSAO DN 8-Fluoro-3-hydroxy-1H-benzo[b]azepine-2,5-dione DMBZSAO MI TTN9D8E DMBZSAO MN Glutamate receptor ionotropic NMDA 2B (NMDAR2B) DMBZSAO MT DTT DMBZSAO MA Inhibitor DMBZSAO RN Analogs of 3-hydroxy-1H-1-benzazepine-2,5-dione: structure-activity relationship at N-methyl-D-aspartate receptor glycine sites. J Med Chem. 1996 Nov 8;39(23):4643-53. DMBZSAO RU https://pubmed.ncbi.nlm.nih.gov/8917653 DMGJ3L6 DI DMGJ3L6 DMGJ3L6 DN 8-Fluoro-6-(4-hydroxy-phenyl)-naphthalen-2-ol DMGJ3L6 MI TTZAYWL DMGJ3L6 MN Estrogen receptor (ESR) DMGJ3L6 MT DTT DMGJ3L6 MA Inhibitor DMGJ3L6 RN ERbeta ligands. 3. Exploiting two binding orientations of the 2-phenylnaphthalene scaffold to achieve ERbeta selectivity. J Med Chem. 2005 Jun 16;48(12):3953-79. DMGJ3L6 RU https://pubmed.ncbi.nlm.nih.gov/15943471 DMGJ3L6 DI DMGJ3L6 DMGJ3L6 DN 8-Fluoro-6-(4-hydroxy-phenyl)-naphthalen-2-ol DMGJ3L6 MI TTOM3J0 DMGJ3L6 MN Estrogen receptor beta (ESR2) DMGJ3L6 MT DTT DMGJ3L6 MA Inhibitor DMGJ3L6 RN ERbeta ligands. 3. Exploiting two binding orientations of the 2-phenylnaphthalene scaffold to achieve ERbeta selectivity. J Med Chem. 2005 Jun 16;48(12):3953-79. DMGJ3L6 RU https://pubmed.ncbi.nlm.nih.gov/15943471 DMKPMFJ DI DMKPMFJ DMKPMFJ DN 8-Fluoro-6H,11H-indeno[1,2-c]isoquinolin-5-one DMKPMFJ MI TTVDSZ0 DMKPMFJ MN Poly [ADP-ribose] polymerase 1 (PARP1) DMKPMFJ MT DTT DMKPMFJ MA Inhibitor DMKPMFJ RN Discovery of potent poly(ADP-ribose) polymerase-1 inhibitors from the modification of indeno[1,2-c]isoquinolinone. J Med Chem. 2005 Aug 11;48(16):5100-3. DMKPMFJ RU https://pubmed.ncbi.nlm.nih.gov/16078828 DMPY9OI DI DMPY9OI DMPY9OI DN 8-furan-2-yl-2-morpholin-4-ylchromen-4-one DMPY9OI MI TTK3PY9 DMPY9OI MN DNA-dependent protein kinase catalytic (PRKDC) DMPY9OI MT DTT DMPY9OI MA Inhibitor DMPY9OI RN Discovery of potent chromen-4-one inhibitors of the DNA-dependent protein kinase (DNA-PK) using a small-molecule library approach. J Med Chem. 2005 Dec 1;48(24):7829-46. DMPY9OI RU https://pubmed.ncbi.nlm.nih.gov/16302822 DMFNCG8 DI DMFNCG8 DMFNCG8 DN 8-Furan-3-yl-6-styryl-naphthalene-2-carboxamidine DMFNCG8 MI TT2WR1T DMFNCG8 MN Cationic trypsinogen (PRSS1) DMFNCG8 MT DTT DMFNCG8 MA Inhibitor DMFNCG8 RN Naphthamidine urokinase plasminogen activator inhibitors with improved pharmacokinetic properties. Bioorg Med Chem Lett. 2005 Jan 3;15(1):93-8. DMFNCG8 RU https://pubmed.ncbi.nlm.nih.gov/15582418 DM7PJN9 DI DM7PJN9 DM7PJN9 DN 8-Hexyloxy-quinolin-2-ylamine DM7PJN9 MI TTX4RTB DM7PJN9 MN Melanin-concentrating hormone receptor 1 (MCHR1) DM7PJN9 MT DTT DM7PJN9 MA Inhibitor DM7PJN9 RN Synthesis and evaluation of 2-amino-8-alkoxy quinolines as MCHr1 antagonists. Part 1. Bioorg Med Chem Lett. 2004 Oct 4;14(19):4873-7. DM7PJN9 RU https://pubmed.ncbi.nlm.nih.gov/15341942 DMNE52B DI DMNE52B DMNE52B DN 8-Hydroxy-2-(4-nitro-phenyl)-3H-quinazolin-4-one DMNE52B MI TTVDSZ0 DMNE52B MN Poly [ADP-ribose] polymerase 1 (PARP1) DMNE52B MT DTT DMNE52B MA Inhibitor DMNE52B RN Resistance-modifying agents. 5. Synthesis and biological properties of quinazolinone inhibitors of the DNA repair enzyme poly(ADP-ribose) polymeras... J Med Chem. 1998 Dec 17;41(26):5247-56. DMNE52B RU https://pubmed.ncbi.nlm.nih.gov/9857092 DMKD2Q4 DI DMKD2Q4 DMKD2Q4 DN 8-Hydroxy-2-phenyl-3H-quinazolin-4-one DMKD2Q4 MI TTVDSZ0 DMKD2Q4 MN Poly [ADP-ribose] polymerase 1 (PARP1) DMKD2Q4 MT DTT DMKD2Q4 MA Inhibitor DMKD2Q4 RN Resistance-modifying agents. 5. Synthesis and biological properties of quinazolinone inhibitors of the DNA repair enzyme poly(ADP-ribose) polymeras... J Med Chem. 1998 Dec 17;41(26):5247-56. DMKD2Q4 RU https://pubmed.ncbi.nlm.nih.gov/9857092 DMG4W2C DI DMG4W2C DMG4W2C DN 8-Hydroxy-5,7,9-trimethyl-delta-carboline DMG4W2C MI TTJFY5U DMG4W2C MN Adenosine A3 receptor (ADORA3) DMG4W2C MT DTT DMG4W2C MA Inhibitor DMG4W2C RN Synthesis of eudistomin D analogues and its effects on adenosine receptors. Bioorg Med Chem. 2008 Apr 1;16(7):3825-30. DMG4W2C RU https://pubmed.ncbi.nlm.nih.gov/18262425 DMFL46R DI DMFL46R DMFL46R DN 8-Hydroxy-7,9-dimethyl-delta-carboline DMFL46R MI TTJFY5U DMFL46R MN Adenosine A3 receptor (ADORA3) DMFL46R MT DTT DMFL46R MA Inhibitor DMFL46R RN Synthesis of eudistomin D analogues and its effects on adenosine receptors. Bioorg Med Chem. 2008 Apr 1;16(7):3825-30. DMFL46R RU https://pubmed.ncbi.nlm.nih.gov/18262425 DMT9BPN DI DMT9BPN DMT9BPN DN 8-hydroxyguanine DMT9BPN MI TTLSWP6 DMT9BPN MN GTP cyclohydrolase-I (GCH1) DMT9BPN MT DTT DMT9BPN MA Inhibitor DMT9BPN RN GTP cyclohydrolase I feedback regulatory protein-dependent and -independent inhibitors of GTP cyclohydrolase I. Arch Biochem Biophys. 2001 Apr 1;388(1):67-73. DMT9BPN RU https://pubmed.ncbi.nlm.nih.gov/11361142 DMA26L4 DI DMA26L4 DMA26L4 DN 8-Imidazol-1-ylmethyl-5-nitro-chromen-4-one DMA26L4 MI TTSZLWK DMA26L4 MN Aromatase (CYP19A1) DMA26L4 MT DTT DMA26L4 MA Inhibitor DMA26L4 RN A new class of nonsteroidal aromatase inhibitors: design and synthesis of chromone and xanthone derivatives and inhibition of the P450 enzymes aromatase and 17 alpha-hydroxylase/C17,20-lyase. J Med Chem. 2001 Mar 1;44(5):672-80. DMA26L4 RU https://pubmed.ncbi.nlm.nih.gov/11262078 DM3K1EO DI DM3K1EO DM3K1EO DN 8-Iodo-Guanine DM3K1EO MI TTMCF1Y DM3K1EO MN Purine nucleoside phosphorylase (PNP) DM3K1EO MT DTT DM3K1EO MA Inhibitor DM3K1EO RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DM3K1EO RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMBIAGJ DI DMBIAGJ DMBIAGJ DN 8-Isopropoxy-quinolin-2-ylamine DMBIAGJ MI TTX4RTB DMBIAGJ MN Melanin-concentrating hormone receptor 1 (MCHR1) DMBIAGJ MT DTT DMBIAGJ MA Inhibitor DMBIAGJ RN Synthesis and evaluation of 2-amino-8-alkoxy quinolines as MCHr1 antagonists. Part 1. Bioorg Med Chem Lett. 2004 Oct 4;14(19):4873-7. DMBIAGJ RU https://pubmed.ncbi.nlm.nih.gov/15341942 DMD3FWU DI DMD3FWU DMD3FWU DN 8-Mercapto-octanoic acid phenylamide DMD3FWU MI TTBH0VX DMD3FWU MN Histone deacetylase (HDAC) DMD3FWU MT DTT DMD3FWU MA Inhibitor DMD3FWU RN Novel inhibitors of human histone deacetylases: design, synthesis, enzyme inhibition, and cancer cell growth inhibition of SAHA-based non-hydroxama... J Med Chem. 2005 Feb 24;48(4):1019-32. DMD3FWU RU https://pubmed.ncbi.nlm.nih.gov/15715470 DMD3FWU DI DMD3FWU DMD3FWU DN 8-Mercapto-octanoic acid phenylamide DMD3FWU MI TT6R7JZ DMD3FWU MN Histone deacetylase 1 (HDAC1) DMD3FWU MT DTT DMD3FWU MA Inhibitor DMD3FWU RN Novel inhibitors of human histone deacetylases: design, synthesis, enzyme inhibition, and cancer cell growth inhibition of SAHA-based non-hydroxama... J Med Chem. 2005 Feb 24;48(4):1019-32. DMD3FWU RU https://pubmed.ncbi.nlm.nih.gov/15715470 DMD3FWU DI DMD3FWU DMD3FWU DN 8-Mercapto-octanoic acid phenylamide DMD3FWU MI TTYHPU6 DMD3FWU MN Histone deacetylase 10 (HDAC10) DMD3FWU MT DTT DMD3FWU MA Inhibitor DMD3FWU RN Novel inhibitors of human histone deacetylases: design, synthesis, enzyme inhibition, and cancer cell growth inhibition of SAHA-based non-hydroxama... J Med Chem. 2005 Feb 24;48(4):1019-32. DMD3FWU RU https://pubmed.ncbi.nlm.nih.gov/15715470 DMD3FWU DI DMD3FWU DMD3FWU DN 8-Mercapto-octanoic acid phenylamide DMD3FWU MI TTSHTOI DMD3FWU MN Histone deacetylase 2 (HDAC2) DMD3FWU MT DTT DMD3FWU MA Inhibitor DMD3FWU RN Novel inhibitors of human histone deacetylases: design, synthesis, enzyme inhibition, and cancer cell growth inhibition of SAHA-based non-hydroxama... J Med Chem. 2005 Feb 24;48(4):1019-32. DMD3FWU RU https://pubmed.ncbi.nlm.nih.gov/15715470 DMD3FWU DI DMD3FWU DMD3FWU DN 8-Mercapto-octanoic acid phenylamide DMD3FWU MI TTTQGH8 DMD3FWU MN Histone deacetylase 4 (HDAC4) DMD3FWU MT DTT DMD3FWU MA Inhibitor DMD3FWU RN Novel inhibitors of human histone deacetylases: design, synthesis, enzyme inhibition, and cancer cell growth inhibition of SAHA-based non-hydroxama... J Med Chem. 2005 Feb 24;48(4):1019-32. DMD3FWU RU https://pubmed.ncbi.nlm.nih.gov/15715470 DMD3FWU DI DMD3FWU DMD3FWU DN 8-Mercapto-octanoic acid phenylamide DMD3FWU MI TT5ZKDI DMD3FWU MN Histone deacetylase 6 (HDAC6) DMD3FWU MT DTT DMD3FWU MA Inhibitor DMD3FWU RN Novel inhibitors of human histone deacetylases: design, synthesis, enzyme inhibition, and cancer cell growth inhibition of SAHA-based non-hydroxama... J Med Chem. 2005 Feb 24;48(4):1019-32. DMD3FWU RU https://pubmed.ncbi.nlm.nih.gov/15715470 DMD3FWU DI DMD3FWU DMD3FWU DN 8-Mercapto-octanoic acid phenylamide DMD3FWU MI TTT6LFV DMD3FWU MN Histone deacetylase 8 (HDAC8) DMD3FWU MT DTT DMD3FWU MA Inhibitor DMD3FWU RN Novel inhibitors of human histone deacetylases: design, synthesis, enzyme inhibition, and cancer cell growth inhibition of SAHA-based non-hydroxama... J Med Chem. 2005 Feb 24;48(4):1019-32. DMD3FWU RU https://pubmed.ncbi.nlm.nih.gov/15715470 DMY50UR DI DMY50UR DMY50UR DN 8-Methoxy-1,2,3,4-tetrahydro-benzo[h]isoquinoline DMY50UR MI TTWG9A4 DMY50UR MN Adrenergic receptor alpha-2A (ADRA2A) DMY50UR MT DTT DMY50UR MA Inhibitor DMY50UR RN Examination of the role of the acidic hydrogen in imparting selectivity of 7-(aminosulfonyl)-1,2,3,4-tetrahydroisoquinoline (SK&F 29661) toward inh... J Med Chem. 1997 Dec 5;40(25):3997-4005. DMY50UR RU https://pubmed.ncbi.nlm.nih.gov/9406590 DMY50UR DI DMY50UR DMY50UR DN 8-Methoxy-1,2,3,4-tetrahydro-benzo[h]isoquinoline DMY50UR MI TTWM4TY DMY50UR MN Adrenergic receptor alpha-2B (ADRA2B) DMY50UR MT DTT DMY50UR MA Inhibitor DMY50UR RN Examination of the role of the acidic hydrogen in imparting selectivity of 7-(aminosulfonyl)-1,2,3,4-tetrahydroisoquinoline (SK&F 29661) toward inh... J Med Chem. 1997 Dec 5;40(25):3997-4005. DMY50UR RU https://pubmed.ncbi.nlm.nih.gov/9406590 DMY50UR DI DMY50UR DMY50UR DN 8-Methoxy-1,2,3,4-tetrahydro-benzo[h]isoquinoline DMY50UR MI TT2NUT5 DMY50UR MN Adrenergic receptor alpha-2C (ADRA2C) DMY50UR MT DTT DMY50UR MA Inhibitor DMY50UR RN Examination of the role of the acidic hydrogen in imparting selectivity of 7-(aminosulfonyl)-1,2,3,4-tetrahydroisoquinoline (SK&F 29661) toward inh... J Med Chem. 1997 Dec 5;40(25):3997-4005. DMY50UR RU https://pubmed.ncbi.nlm.nih.gov/9406590 DMFOM10 DI DMFOM10 DMFOM10 DN 8-Methoxy-1,2,3,4-tetrahydro-naphthalen-2-ylamine DMFOM10 MI TTSQIFT DMFOM10 MN 5-HT 1A receptor (HTR1A) DMFOM10 MT DTT DMFOM10 MA Inhibitor DMFOM10 RN Synthesis of new derivatives of 8-OH-DPAT: Influence of substitution on the aromatic ring on the pharmacological profile, Bioorg. Med. Chem. Lett. 3(10):2035-2038 (1993). DMFOM10 RU http://www.sciencedirect.com/science/article/pii/S0960894X0181009X DM0Y52J DI DM0Y52J DM0Y52J DN 8-Methoxy-1,4-dimethylquinolin-2(1H)-one DM0Y52J MI TTJLP0R DM0Y52J MN Quinone reductase 2 (NQO2) DM0Y52J MT DTT DM0Y52J MA Inhibitor DM0Y52J RN Synthesis of casimiroin and optimization of its quinone reductase 2 and aromatase inhibitory activities. J Med Chem. 2009 Apr 9;52(7):1873-84. DM0Y52J RU https://pubmed.ncbi.nlm.nih.gov/19265439 DMQIFZC DI DMQIFZC DMQIFZC DN 8-Methoxy-2-(4-methyl-piperazin-1-yl)-quinoline DMQIFZC MI TTSQIFT DMQIFZC MN 5-HT 1A receptor (HTR1A) DMQIFZC MT DTT DMQIFZC MA Inhibitor DMQIFZC RN 5-HT1 and 5-HT2 binding characteristics of some quipazine analogues. J Med Chem. 1986 Nov;29(11):2375-80. DMQIFZC RU https://pubmed.ncbi.nlm.nih.gov/3783595 DMQIFZC DI DMQIFZC DMQIFZC DN 8-Methoxy-2-(4-methyl-piperazin-1-yl)-quinoline DMQIFZC MI TT6MSOK DMQIFZC MN 5-HT 1D receptor (HTR1D) DMQIFZC MT DTT DMQIFZC MA Inhibitor DMQIFZC RN 5-HT1 and 5-HT2 binding characteristics of some quipazine analogues. J Med Chem. 1986 Nov;29(11):2375-80. DMQIFZC RU https://pubmed.ncbi.nlm.nih.gov/3783595 DMQIFZC DI DMQIFZC DMQIFZC DN 8-Methoxy-2-(4-methyl-piperazin-1-yl)-quinoline DMQIFZC MI TTJQOD7 DMQIFZC MN 5-HT 2A receptor (HTR2A) DMQIFZC MT DTT DMQIFZC MA Inhibitor DMQIFZC RN 5-HT1 and 5-HT2 binding characteristics of some quipazine analogues. J Med Chem. 1986 Nov;29(11):2375-80. DMQIFZC RU https://pubmed.ncbi.nlm.nih.gov/3783595 DMSN0ZE DI DMSN0ZE DMSN0ZE DN 8-Methoxy-2-(4-nitro-phenyl)-3H-quinazolin-4-one DMSN0ZE MI TTVDSZ0 DMSN0ZE MN Poly [ADP-ribose] polymerase 1 (PARP1) DMSN0ZE MT DTT DMSN0ZE MA Inhibitor DMSN0ZE RN Resistance-modifying agents. 5. Synthesis and biological properties of quinazolinone inhibitors of the DNA repair enzyme poly(ADP-ribose) polymeras... J Med Chem. 1998 Dec 17;41(26):5247-56. DMSN0ZE RU https://pubmed.ncbi.nlm.nih.gov/9857092 DMHE7J5 DI DMHE7J5 DMHE7J5 DN 8-Methoxy-2,3,4,9-tetrahydro-1H-beta-carboline DMHE7J5 MI TTJQOD7 DMHE7J5 MN 5-HT 2A receptor (HTR2A) DMHE7J5 MT DTT DMHE7J5 MA Inhibitor DMHE7J5 RN Binding of beta-carbolines at 5-HT(2) serotonin receptors. Bioorg Med Chem Lett. 2003 Dec 15;13(24):4421-5. DMHE7J5 RU https://pubmed.ncbi.nlm.nih.gov/14643338 DMHE7J5 DI DMHE7J5 DMHE7J5 DN 8-Methoxy-2,3,4,9-tetrahydro-1H-beta-carboline DMHE7J5 MI TT3WG5C DMHE7J5 MN Monoamine oxidase type A (MAO-A) DMHE7J5 MT DTT DMHE7J5 MA Inhibitor DMHE7J5 RN Binding of beta-carbolines at imidazoline I2 receptors: a structure-affinity investigation. Bioorg Med Chem Lett. 2004 Feb 23;14(4):999-1002. DMHE7J5 RU https://pubmed.ncbi.nlm.nih.gov/15013009 DMHE7J5 DI DMHE7J5 DMHE7J5 DN 8-Methoxy-2,3,4,9-tetrahydro-1H-beta-carboline DMHE7J5 MI TTGP7BY DMHE7J5 MN Monoamine oxidase type B (MAO-B) DMHE7J5 MT DTT DMHE7J5 MA Inhibitor DMHE7J5 RN Binding of beta-carbolines at imidazoline I2 receptors: a structure-affinity investigation. Bioorg Med Chem Lett. 2004 Feb 23;14(4):999-1002. DMHE7J5 RU https://pubmed.ncbi.nlm.nih.gov/15013009 DMOPN4K DI DMOPN4K DMOPN4K DN 8-Methoxy-2-methyl-3H-quinazolin-4-one DMOPN4K MI TTVDSZ0 DMOPN4K MN Poly [ADP-ribose] polymerase 1 (PARP1) DMOPN4K MT DTT DMOPN4K MA Inhibitor DMOPN4K RN Resistance-modifying agents. 5. Synthesis and biological properties of quinazolinone inhibitors of the DNA repair enzyme poly(ADP-ribose) polymeras... J Med Chem. 1998 Dec 17;41(26):5247-56. DMOPN4K RU https://pubmed.ncbi.nlm.nih.gov/9857092 DMYE1X2 DI DMYE1X2 DMYE1X2 DN 8-Methoxy-2-morpholin-4-yl-chromen-4-one DMYE1X2 MI TTK3PY9 DMYE1X2 MN DNA-dependent protein kinase catalytic (PRKDC) DMYE1X2 MT DTT DMYE1X2 MA Inhibitor DMYE1X2 RN Selective benzopyranone and pyrimido[2,1-a]isoquinolin-4-one inhibitors of DNA-dependent protein kinase: synthesis, structure-activity studies, and... J Med Chem. 2005 Jan 27;48(2):569-85. DMYE1X2 RU https://pubmed.ncbi.nlm.nih.gov/15658870 DMHCWY8 DI DMHCWY8 DMHCWY8 DN 8-methoxy-2-oxo-2H-chromene-3-carboxylic acid DMHCWY8 MI TTUNARX DMHCWY8 MN Carbonic anhydrase (CA) DMHCWY8 MT DTT DMHCWY8 MA Inhibitor DMHCWY8 RN Deciphering the mechanism of carbonic anhydrase inhibition with coumarins and thiocoumarins. J Med Chem. 2010 Jan 14;53(1):335-44. DMHCWY8 RU https://pubmed.ncbi.nlm.nih.gov/19911821 DMHCWY8 DI DMHCWY8 DMHCWY8 DN 8-methoxy-2-oxo-2H-chromene-3-carboxylic acid DMHCWY8 MI TTHQPL7 DMHCWY8 MN Carbonic anhydrase I (CA-I) DMHCWY8 MT DTT DMHCWY8 MA Inhibitor DMHCWY8 RN Deciphering the mechanism of carbonic anhydrase inhibition with coumarins and thiocoumarins. J Med Chem. 2010 Jan 14;53(1):335-44. DMHCWY8 RU https://pubmed.ncbi.nlm.nih.gov/19911821 DMHCWY8 DI DMHCWY8 DMHCWY8 DN 8-methoxy-2-oxo-2H-chromene-3-carboxylic acid DMHCWY8 MI TT2LVK8 DMHCWY8 MN Carbonic anhydrase IX (CA-IX) DMHCWY8 MT DTT DMHCWY8 MA Inhibitor DMHCWY8 RN Deciphering the mechanism of carbonic anhydrase inhibition with coumarins and thiocoumarins. J Med Chem. 2010 Jan 14;53(1):335-44. DMHCWY8 RU https://pubmed.ncbi.nlm.nih.gov/19911821 DMHCWY8 DI DMHCWY8 DMHCWY8 DN 8-methoxy-2-oxo-2H-chromene-3-carboxylic acid DMHCWY8 MI TTSYM0R DMHCWY8 MN Carbonic anhydrase XII (CA-XII) DMHCWY8 MT DTT DMHCWY8 MA Inhibitor DMHCWY8 RN Deciphering the mechanism of carbonic anhydrase inhibition with coumarins and thiocoumarins. J Med Chem. 2010 Jan 14;53(1):335-44. DMHCWY8 RU https://pubmed.ncbi.nlm.nih.gov/19911821 DMHCWY8 DI DMHCWY8 DMHCWY8 DN 8-methoxy-2-oxo-2H-chromene-3-carboxylic acid DMHCWY8 MI TTEYTKG DMHCWY8 MN Carbonic anhydrase XIV (CA-XIV) DMHCWY8 MT DTT DMHCWY8 MA Inhibitor DMHCWY8 RN Deciphering the mechanism of carbonic anhydrase inhibition with coumarins and thiocoumarins. J Med Chem. 2010 Jan 14;53(1):335-44. DMHCWY8 RU https://pubmed.ncbi.nlm.nih.gov/19911821 DM56EW7 DI DM56EW7 DM56EW7 DN 8-Methoxy-2-phenyl-3H-quinazolin-4-one DM56EW7 MI TTVDSZ0 DM56EW7 MN Poly [ADP-ribose] polymerase 1 (PARP1) DM56EW7 MT DTT DM56EW7 MA Inhibitor DM56EW7 RN Resistance-modifying agents. 5. Synthesis and biological properties of quinazolinone inhibitors of the DNA repair enzyme poly(ADP-ribose) polymeras... J Med Chem. 1998 Dec 17;41(26):5247-56. DM56EW7 RU https://pubmed.ncbi.nlm.nih.gov/9857092 DMNWC29 DI DMNWC29 DMNWC29 DN 8-Methoxy-2-piperazin-1-yl-quinoline DMNWC29 MI TTSQIFT DMNWC29 MN 5-HT 1A receptor (HTR1A) DMNWC29 MT DTT DMNWC29 MA Inhibitor DMNWC29 RN 5-HT1 and 5-HT2 binding characteristics of some quipazine analogues. J Med Chem. 1986 Nov;29(11):2375-80. DMNWC29 RU https://pubmed.ncbi.nlm.nih.gov/3783595 DMNWC29 DI DMNWC29 DMNWC29 DN 8-Methoxy-2-piperazin-1-yl-quinoline DMNWC29 MI TT6MSOK DMNWC29 MN 5-HT 1D receptor (HTR1D) DMNWC29 MT DTT DMNWC29 MA Inhibitor DMNWC29 RN 5-HT1 and 5-HT2 binding characteristics of some quipazine analogues. J Med Chem. 1986 Nov;29(11):2375-80. DMNWC29 RU https://pubmed.ncbi.nlm.nih.gov/3783595 DMNWC29 DI DMNWC29 DMNWC29 DN 8-Methoxy-2-piperazin-1-yl-quinoline DMNWC29 MI TTJQOD7 DMNWC29 MN 5-HT 2A receptor (HTR2A) DMNWC29 MT DTT DMNWC29 MA Inhibitor DMNWC29 RN 5-HT1 and 5-HT2 binding characteristics of some quipazine analogues. J Med Chem. 1986 Nov;29(11):2375-80. DMNWC29 RU https://pubmed.ncbi.nlm.nih.gov/3783595 DM8MBSN DI DM8MBSN DM8MBSN DN 8-Methoxy-4,9-dihydro-3H-beta-carboline DM8MBSN MI TTJQOD7 DM8MBSN MN 5-HT 2A receptor (HTR2A) DM8MBSN MT DTT DM8MBSN MA Inhibitor DM8MBSN RN Binding of beta-carbolines at 5-HT(2) serotonin receptors. Bioorg Med Chem Lett. 2003 Dec 15;13(24):4421-5. DM8MBSN RU https://pubmed.ncbi.nlm.nih.gov/14643338 DM8MBSN DI DM8MBSN DM8MBSN DN 8-Methoxy-4,9-dihydro-3H-beta-carboline DM8MBSN MI TT3WG5C DM8MBSN MN Monoamine oxidase type A (MAO-A) DM8MBSN MT DTT DM8MBSN MA Inhibitor DM8MBSN RN Binding of beta-carbolines at imidazoline I2 receptors: a structure-affinity investigation. Bioorg Med Chem Lett. 2004 Feb 23;14(4):999-1002. DM8MBSN RU https://pubmed.ncbi.nlm.nih.gov/15013009 DM8MBSN DI DM8MBSN DM8MBSN DN 8-Methoxy-4,9-dihydro-3H-beta-carboline DM8MBSN MI TTGP7BY DM8MBSN MN Monoamine oxidase type B (MAO-B) DM8MBSN MT DTT DM8MBSN MA Inhibitor DM8MBSN RN Binding of beta-carbolines at imidazoline I2 receptors: a structure-affinity investigation. Bioorg Med Chem Lett. 2004 Feb 23;14(4):999-1002. DM8MBSN RU https://pubmed.ncbi.nlm.nih.gov/15013009 DMK6U2V DI DMK6U2V DMK6U2V DN 8-methoxy-4-methyl-3,4-dihydroquinazolin-2-amine DMK6U2V MI TTSQIFT DMK6U2V MN 5-HT 1A receptor (HTR1A) DMK6U2V MT DTT DMK6U2V MA Inhibitor DMK6U2V RN Cyclic guanidines as dual 5-HT5A/5-HT7 receptor ligands: structure-activity relationship elucidation. Bioorg Med Chem Lett. 2008 Jan 1;18(1):256-61. DMK6U2V RU https://pubmed.ncbi.nlm.nih.gov/17998160 DMK6U2V DI DMK6U2V DMK6U2V DN 8-methoxy-4-methyl-3,4-dihydroquinazolin-2-amine DMK6U2V MI TT6MSOK DMK6U2V MN 5-HT 1D receptor (HTR1D) DMK6U2V MT DTT DMK6U2V MA Inhibitor DMK6U2V RN Cyclic guanidines as dual 5-HT5A/5-HT7 receptor ligands: structure-activity relationship elucidation. Bioorg Med Chem Lett. 2008 Jan 1;18(1):256-61. DMK6U2V RU https://pubmed.ncbi.nlm.nih.gov/17998160 DMK6U2V DI DMK6U2V DMK6U2V DN 8-methoxy-4-methyl-3,4-dihydroquinazolin-2-amine DMK6U2V MI TTWJBZ5 DMK6U2V MN 5-HT 2C receptor (HTR2C) DMK6U2V MT DTT DMK6U2V MA Inhibitor DMK6U2V RN Cyclic guanidines as dual 5-HT5A/5-HT7 receptor ligands: structure-activity relationship elucidation. Bioorg Med Chem Lett. 2008 Jan 1;18(1):256-61. DMK6U2V RU https://pubmed.ncbi.nlm.nih.gov/17998160 DMK6U2V DI DMK6U2V DMK6U2V DN 8-methoxy-4-methyl-3,4-dihydroquinazolin-2-amine DMK6U2V MI TTRUFDT DMK6U2V MN 5-HT 5A receptor (HTR5A) DMK6U2V MT DTT DMK6U2V MA Inhibitor DMK6U2V RN Cyclic guanidines as dual 5-HT5A/5-HT7 receptor ligands: structure-activity relationship elucidation. Bioorg Med Chem Lett. 2008 Jan 1;18(1):256-61. DMK6U2V RU https://pubmed.ncbi.nlm.nih.gov/17998160 DMK6U2V DI DMK6U2V DMK6U2V DN 8-methoxy-4-methyl-3,4-dihydroquinazolin-2-amine DMK6U2V MI TTO9X1H DMK6U2V MN 5-HT 7 receptor (HTR7) DMK6U2V MT DTT DMK6U2V MA Inhibitor DMK6U2V RN Cyclic guanidines as dual 5-HT5A/5-HT7 receptor ligands: structure-activity relationship elucidation. Bioorg Med Chem Lett. 2008 Jan 1;18(1):256-61. DMK6U2V RU https://pubmed.ncbi.nlm.nih.gov/17998160 DMHLKAE DI DMHLKAE DMHLKAE DN 8-Methoxy-4-morpholin-4-yl-chromen-2-one DMHLKAE MI TTK3PY9 DMHLKAE MN DNA-dependent protein kinase catalytic (PRKDC) DMHLKAE MT DTT DMHLKAE MA Inhibitor DMHLKAE RN Selective benzopyranone and pyrimido[2,1-a]isoquinolin-4-one inhibitors of DNA-dependent protein kinase: synthesis, structure-activity studies, and... J Med Chem. 2005 Jan 27;48(2):569-85. DMHLKAE RU https://pubmed.ncbi.nlm.nih.gov/15658870 DMHZ5SB DI DMHZ5SB DMHZ5SB DN 8-Methoxy-quinolin-2-ylamine DMHZ5SB MI TTSQIFT DMHZ5SB MN 5-HT 1A receptor (HTR1A) DMHZ5SB MT DTT DMHZ5SB MA Inhibitor DMHZ5SB RN 5-HT1 and 5-HT2 binding characteristics of some quipazine analogues. J Med Chem. 1986 Nov;29(11):2375-80. DMHZ5SB RU https://pubmed.ncbi.nlm.nih.gov/3783595 DMHZ5SB DI DMHZ5SB DMHZ5SB DN 8-Methoxy-quinolin-2-ylamine DMHZ5SB MI TT6MSOK DMHZ5SB MN 5-HT 1D receptor (HTR1D) DMHZ5SB MT DTT DMHZ5SB MA Inhibitor DMHZ5SB RN 5-HT1 and 5-HT2 binding characteristics of some quipazine analogues. J Med Chem. 1986 Nov;29(11):2375-80. DMHZ5SB RU https://pubmed.ncbi.nlm.nih.gov/3783595 DMHZ5SB DI DMHZ5SB DMHZ5SB DN 8-Methoxy-quinolin-2-ylamine DMHZ5SB MI TTX4RTB DMHZ5SB MN Melanin-concentrating hormone receptor 1 (MCHR1) DMHZ5SB MT DTT DMHZ5SB MA Inhibitor DMHZ5SB RN Synthesis and evaluation of 2-amino-8-alkoxy quinolines as MCHr1 antagonists. Part 1. Bioorg Med Chem Lett. 2004 Oct 4;14(19):4873-7. DMHZ5SB RU https://pubmed.ncbi.nlm.nih.gov/15341942 DM92XPO DI DM92XPO DM92XPO DN 8-Methyl-1,3-dihydro-imidazo[4,5-b]quinolin-2-one DM92XPO MI TT06AWU DM92XPO MN Phosphodiesterase 3A (PDE3A) DM92XPO MT DTT DM92XPO MA Inhibitor DM92XPO RN 1,3-Dihydro-2H-imidazo[4,5-b]quinolin-2-ones--inhibitors of blood platelet cAMP phosphodiesterase and induced aggregation. J Med Chem. 1991 Sep;34(9):2906-16. DM92XPO RU https://pubmed.ncbi.nlm.nih.gov/1654430 DM7FSZM DI DM7FSZM DM7FSZM DN 8-Methyl-2-(4-nitro-phenyl)-3H-quinazolin-4-one DM7FSZM MI TTVDSZ0 DM7FSZM MN Poly [ADP-ribose] polymerase 1 (PARP1) DM7FSZM MT DTT DM7FSZM MA Inhibitor DM7FSZM RN Resistance-modifying agents. 5. Synthesis and biological properties of quinazolinone inhibitors of the DNA repair enzyme poly(ADP-ribose) polymeras... J Med Chem. 1998 Dec 17;41(26):5247-56. DM7FSZM RU https://pubmed.ncbi.nlm.nih.gov/9857092 DMLQ90D DI DMLQ90D DMLQ90D DN 8-Methyl-2-morpholin-4-yl-chromen-4-one DMLQ90D MI TTK3PY9 DMLQ90D MN DNA-dependent protein kinase catalytic (PRKDC) DMLQ90D MT DTT DMLQ90D MA Inhibitor DMLQ90D RN Selective benzopyranone and pyrimido[2,1-a]isoquinolin-4-one inhibitors of DNA-dependent protein kinase: synthesis, structure-activity studies, and... J Med Chem. 2005 Jan 27;48(2):569-85. DMLQ90D RU https://pubmed.ncbi.nlm.nih.gov/15658870 DMWZ27A DI DMWZ27A DMWZ27A DN 8-methyl-2-morpholino-7-phenoxy-4H-chromen-4-one DMWZ27A MI TT06AWU DMWZ27A MN Phosphodiesterase 3A (PDE3A) DMWZ27A MT DTT DMWZ27A MA Inhibitor DMWZ27A RN Analysis of anti-PDE3 activity of 2-morpholinochromone derivatives reveals multiple mechanisms of anti-platelet activity. Bioorg Med Chem Lett. 2006 Feb 15;16(4):969-73. DMWZ27A RU https://pubmed.ncbi.nlm.nih.gov/16290931 DMUI1YZ DI DMUI1YZ DMUI1YZ DN 8-methyl-2-morpholino-7-phenyl-4H-chromen-4-one DMUI1YZ MI TT06AWU DMUI1YZ MN Phosphodiesterase 3A (PDE3A) DMUI1YZ MT DTT DMUI1YZ MA Inhibitor DMUI1YZ RN Analysis of anti-PDE3 activity of 2-morpholinochromone derivatives reveals multiple mechanisms of anti-platelet activity. Bioorg Med Chem Lett. 2006 Feb 15;16(4):969-73. DMUI1YZ RU https://pubmed.ncbi.nlm.nih.gov/16290931 DMEM6Q0 DI DMEM6Q0 DMEM6Q0 DN 8-Methyl-2-phenyl-3H-quinazolin-4-one DMEM6Q0 MI TTVDSZ0 DMEM6Q0 MN Poly [ADP-ribose] polymerase 1 (PARP1) DMEM6Q0 MT DTT DMEM6Q0 MA Inhibitor DMEM6Q0 RN Resistance-modifying agents. 5. Synthesis and biological properties of quinazolinone inhibitors of the DNA repair enzyme poly(ADP-ribose) polymeras... J Med Chem. 1998 Dec 17;41(26):5247-56. DMEM6Q0 RU https://pubmed.ncbi.nlm.nih.gov/9857092 DMOM4VS DI DMOM4VS DMOM4VS DN 8-Methyl-3-p-tolyl-8-aza-bicyclo[3.2.1]octane DMOM4VS MI TTVBI8W DMOM4VS MN Dopamine transporter (DAT) DMOM4VS MT DTT DMOM4VS MA Inhibitor DMOM4VS RN 3alpha-(4-Substituted phenyl)nortropane-2beta-carboxylic acid methyl esters show selective binding at the norepinephrine transporter. Bioorg Med Chem Lett. 2000 Nov 6;10(21):2445-7. DMOM4VS RU https://pubmed.ncbi.nlm.nih.gov/11078197 DMOM4VS DI DMOM4VS DMOM4VS DN 8-Methyl-3-p-tolyl-8-aza-bicyclo[3.2.1]octane DMOM4VS MI TTAWNKZ DMOM4VS MN Norepinephrine transporter (NET) DMOM4VS MT DTT DMOM4VS MA Inhibitor DMOM4VS RN 3alpha-(4-Substituted phenyl)nortropane-2beta-carboxylic acid methyl esters show selective binding at the norepinephrine transporter. Bioorg Med Chem Lett. 2000 Nov 6;10(21):2445-7. DMOM4VS RU https://pubmed.ncbi.nlm.nih.gov/11078197 DMOM4VS DI DMOM4VS DMOM4VS DN 8-Methyl-3-p-tolyl-8-aza-bicyclo[3.2.1]octane DMOM4VS MI TT3ROYC DMOM4VS MN Serotonin transporter (SERT) DMOM4VS MT DTT DMOM4VS MA Inhibitor DMOM4VS RN 3alpha-(4-Substituted phenyl)nortropane-2beta-carboxylic acid methyl esters show selective binding at the norepinephrine transporter. Bioorg Med Chem Lett. 2000 Nov 6;10(21):2445-7. DMOM4VS RU https://pubmed.ncbi.nlm.nih.gov/11078197 DMA28OL DI DMA28OL DMA28OL DN 8-methyl-4H,7H-indolo[6,5,4-cd]indol-5-one DMA28OL MI TTUTJGQ DMA28OL MN Vascular endothelial growth factor receptor 2 (KDR) DMA28OL MT DTT DMA28OL MA Inhibitor DMA28OL RN Pharmacophore modeling and in silico screening for new KDR kinase inhibitors. Bioorg Med Chem Lett. 2007 Apr 15;17(8):2126-33. DMA28OL RU https://pubmed.ncbi.nlm.nih.gov/17306530 DMVAOIG DI DMVAOIG DMVAOIG DN 8-Methyl-4-morpholin-4-yl-chromen-2-one DMVAOIG MI TTK3PY9 DMVAOIG MN DNA-dependent protein kinase catalytic (PRKDC) DMVAOIG MT DTT DMVAOIG MA Inhibitor DMVAOIG RN Selective benzopyranone and pyrimido[2,1-a]isoquinolin-4-one inhibitors of DNA-dependent protein kinase: synthesis, structure-activity studies, and... J Med Chem. 2005 Jan 27;48(2):569-85. DMVAOIG RU https://pubmed.ncbi.nlm.nih.gov/15658870 DMK63P2 DI DMK63P2 DMK63P2 DN 8-methylnaringenin DMK63P2 MI TTZAYWL DMK63P2 MN Estrogen receptor (ESR) DMK63P2 MT DTT DMK63P2 MA Inhibitor DMK63P2 RN Subtle side-chain modifications of the hop phytoestrogen 8-prenylnaringenin result in distinct agonist/antagonist activity profiles for estrogen re... J Med Chem. 2006 Dec 14;49(25):7357-65. DMK63P2 RU https://pubmed.ncbi.nlm.nih.gov/17149865 DMK63P2 DI DMK63P2 DMK63P2 DN 8-methylnaringenin DMK63P2 MI TTOM3J0 DMK63P2 MN Estrogen receptor beta (ESR2) DMK63P2 MT DTT DMK63P2 MA Inhibitor DMK63P2 RN Subtle side-chain modifications of the hop phytoestrogen 8-prenylnaringenin result in distinct agonist/antagonist activity profiles for estrogen re... J Med Chem. 2006 Dec 14;49(25):7357-65. DMK63P2 RU https://pubmed.ncbi.nlm.nih.gov/17149865 DMWMVI3 DI DMWMVI3 DMWMVI3 DN 8-n-heptylnaringenin DMWMVI3 MI TTZAYWL DMWMVI3 MN Estrogen receptor (ESR) DMWMVI3 MT DTT DMWMVI3 MA Inhibitor DMWMVI3 RN Subtle side-chain modifications of the hop phytoestrogen 8-prenylnaringenin result in distinct agonist/antagonist activity profiles for estrogen re... J Med Chem. 2006 Dec 14;49(25):7357-65. DMWMVI3 RU https://pubmed.ncbi.nlm.nih.gov/17149865 DMWMVI3 DI DMWMVI3 DMWMVI3 DN 8-n-heptylnaringenin DMWMVI3 MI TTOM3J0 DMWMVI3 MN Estrogen receptor beta (ESR2) DMWMVI3 MT DTT DMWMVI3 MA Inhibitor DMWMVI3 RN Subtle side-chain modifications of the hop phytoestrogen 8-prenylnaringenin result in distinct agonist/antagonist activity profiles for estrogen re... J Med Chem. 2006 Dec 14;49(25):7357-65. DMWMVI3 RU https://pubmed.ncbi.nlm.nih.gov/17149865 DM5L40C DI DM5L40C DM5L40C DN 8-Nitro-6H,11H-indeno[1,2-c]isoquinolin-5-one DM5L40C MI TTVDSZ0 DM5L40C MN Poly [ADP-ribose] polymerase 1 (PARP1) DM5L40C MT DTT DM5L40C MA Inhibitor DM5L40C RN Discovery of potent poly(ADP-ribose) polymerase-1 inhibitors from the modification of indeno[1,2-c]isoquinolinone. J Med Chem. 2005 Aug 11;48(16):5100-3. DM5L40C RU https://pubmed.ncbi.nlm.nih.gov/16078828 DMC2JLQ DI DMC2JLQ DMC2JLQ DN 8-n-nonylnaringenin DMC2JLQ MI TTZAYWL DMC2JLQ MN Estrogen receptor (ESR) DMC2JLQ MT DTT DMC2JLQ MA Inhibitor DMC2JLQ RN Subtle side-chain modifications of the hop phytoestrogen 8-prenylnaringenin result in distinct agonist/antagonist activity profiles for estrogen re... J Med Chem. 2006 Dec 14;49(25):7357-65. DMC2JLQ RU https://pubmed.ncbi.nlm.nih.gov/17149865 DMC2JLQ DI DMC2JLQ DMC2JLQ DN 8-n-nonylnaringenin DMC2JLQ MI TTOM3J0 DMC2JLQ MN Estrogen receptor beta (ESR2) DMC2JLQ MT DTT DMC2JLQ MA Inhibitor DMC2JLQ RN Subtle side-chain modifications of the hop phytoestrogen 8-prenylnaringenin result in distinct agonist/antagonist activity profiles for estrogen re... J Med Chem. 2006 Dec 14;49(25):7357-65. DMC2JLQ RU https://pubmed.ncbi.nlm.nih.gov/17149865 DMRDOP0 DI DMRDOP0 DMRDOP0 DN 8-n-pentylnaringenin DMRDOP0 MI TTZAYWL DMRDOP0 MN Estrogen receptor (ESR) DMRDOP0 MT DTT DMRDOP0 MA Inhibitor DMRDOP0 RN Subtle side-chain modifications of the hop phytoestrogen 8-prenylnaringenin result in distinct agonist/antagonist activity profiles for estrogen re... J Med Chem. 2006 Dec 14;49(25):7357-65. DMRDOP0 RU https://pubmed.ncbi.nlm.nih.gov/17149865 DMRDOP0 DI DMRDOP0 DMRDOP0 DN 8-n-pentylnaringenin DMRDOP0 MI TTOM3J0 DMRDOP0 MN Estrogen receptor beta (ESR2) DMRDOP0 MT DTT DMRDOP0 MA Inhibitor DMRDOP0 RN Subtle side-chain modifications of the hop phytoestrogen 8-prenylnaringenin result in distinct agonist/antagonist activity profiles for estrogen re... J Med Chem. 2006 Dec 14;49(25):7357-65. DMRDOP0 RU https://pubmed.ncbi.nlm.nih.gov/17149865 DMDOW5S DI DMDOW5S DMDOW5S DN 8-n-propylnaringenin DMDOW5S MI TTZAYWL DMDOW5S MN Estrogen receptor (ESR) DMDOW5S MT DTT DMDOW5S MA Inhibitor DMDOW5S RN Subtle side-chain modifications of the hop phytoestrogen 8-prenylnaringenin result in distinct agonist/antagonist activity profiles for estrogen re... J Med Chem. 2006 Dec 14;49(25):7357-65. DMDOW5S RU https://pubmed.ncbi.nlm.nih.gov/17149865 DMDOW5S DI DMDOW5S DMDOW5S DN 8-n-propylnaringenin DMDOW5S MI TTOM3J0 DMDOW5S MN Estrogen receptor beta (ESR2) DMDOW5S MT DTT DMDOW5S MA Inhibitor DMDOW5S RN Subtle side-chain modifications of the hop phytoestrogen 8-prenylnaringenin result in distinct agonist/antagonist activity profiles for estrogen re... J Med Chem. 2006 Dec 14;49(25):7357-65. DMDOW5S RU https://pubmed.ncbi.nlm.nih.gov/17149865 DMXURM8 DI DMXURM8 DMXURM8 DN 8-n-undecylnaringenin DMXURM8 MI TTZAYWL DMXURM8 MN Estrogen receptor (ESR) DMXURM8 MT DTT DMXURM8 MA Inhibitor DMXURM8 RN Subtle side-chain modifications of the hop phytoestrogen 8-prenylnaringenin result in distinct agonist/antagonist activity profiles for estrogen re... J Med Chem. 2006 Dec 14;49(25):7357-65. DMXURM8 RU https://pubmed.ncbi.nlm.nih.gov/17149865 DMXURM8 DI DMXURM8 DMXURM8 DN 8-n-undecylnaringenin DMXURM8 MI TTOM3J0 DMXURM8 MN Estrogen receptor beta (ESR2) DMXURM8 MT DTT DMXURM8 MA Inhibitor DMXURM8 RN Subtle side-chain modifications of the hop phytoestrogen 8-prenylnaringenin result in distinct agonist/antagonist activity profiles for estrogen re... J Med Chem. 2006 Dec 14;49(25):7357-65. DMXURM8 RU https://pubmed.ncbi.nlm.nih.gov/17149865 DMDRPLA DI DMDRPLA DMDRPLA DN 8-O-(4-bromobenzenesulfonyl)manzamine F DMDRPLA MI TTRSMW9 DMDRPLA MN Glycogen synthase kinase-3 beta (GSK-3B) DMDRPLA MT DTT DMDRPLA MA Inhibitor DMDRPLA RN Glycogen synthase kinase-3 (GSK-3) inhibitory activity and structure-activity relationship (SAR) studies of the manzamine alkaloids. Potential for ... J Nat Prod. 2007 Sep;70(9):1397-405. DMDRPLA RU https://pubmed.ncbi.nlm.nih.gov/17708655 DM48JMC DI DM48JMC DM48JMC DN 8-O-(4-chlorobenzenesulfonyl)manzamine F DM48JMC MI TTRSMW9 DM48JMC MN Glycogen synthase kinase-3 beta (GSK-3B) DM48JMC MT DTT DM48JMC MA Inhibitor DM48JMC RN Glycogen synthase kinase-3 (GSK-3) inhibitory activity and structure-activity relationship (SAR) studies of the manzamine alkaloids. Potential for ... J Nat Prod. 2007 Sep;70(9):1397-405. DM48JMC RU https://pubmed.ncbi.nlm.nih.gov/17708655 DM249GI DI DM249GI DM249GI DN 8-O-(4-toluenesulfonyl)manzamine A DM249GI MI TTRSMW9 DM249GI MN Glycogen synthase kinase-3 beta (GSK-3B) DM249GI MT DTT DM249GI MA Inhibitor DM249GI RN Glycogen synthase kinase-3 (GSK-3) inhibitory activity and structure-activity relationship (SAR) studies of the manzamine alkaloids. Potential for ... J Nat Prod. 2007 Sep;70(9):1397-405. DM249GI RU https://pubmed.ncbi.nlm.nih.gov/17708655 DM4Z15M DI DM4Z15M DM4Z15M DN 8-Octyl-benzolactam-V9 DM4Z15M MI TT7A1BO DM4Z15M MN PKC-delta messenger RNA (PRKCD mRNA) DM4Z15M MT DTT DM4Z15M MA Inhibitor DM4Z15M RN Design and synthesis of 8-octyl-benzolactam-V9, a selective activator for protein kinase C epsilon and eta. J Med Chem. 2006 May 4;49(9):2681-8. DM4Z15M RU https://pubmed.ncbi.nlm.nih.gov/16640328 DM4Z15M DI DM4Z15M DM4Z15M DN 8-Octyl-benzolactam-V9 DM4Z15M MI TT57MT2 DM4Z15M MN PKC-epsilon messenger RNA (PRKCE mRNA) DM4Z15M MT DTT DM4Z15M MA Inhibitor DM4Z15M RN Design and synthesis of 8-octyl-benzolactam-V9, a selective activator for protein kinase C epsilon and eta. J Med Chem. 2006 May 4;49(9):2681-8. DM4Z15M RU https://pubmed.ncbi.nlm.nih.gov/16640328 DM4Z15M DI DM4Z15M DM4Z15M DN 8-Octyl-benzolactam-V9 DM4Z15M MI TTONI0R DM4Z15M MN PKC-eta messenger RNA (PRKCH mRNA) DM4Z15M MT DTT DM4Z15M MA Inhibitor DM4Z15M RN Design and synthesis of 8-octyl-benzolactam-V9, a selective activator for protein kinase C epsilon and eta. J Med Chem. 2006 May 4;49(9):2681-8. DM4Z15M RU https://pubmed.ncbi.nlm.nih.gov/16640328 DM4Z15M DI DM4Z15M DM4Z15M DN 8-Octyl-benzolactam-V9 DM4Z15M MI TT1MS7X DM4Z15M MN PKC-theta messenger RNA (PRKCQ mRNA) DM4Z15M MT DTT DM4Z15M MA Inhibitor DM4Z15M RN Design and synthesis of 8-octyl-benzolactam-V9, a selective activator for protein kinase C epsilon and eta. J Med Chem. 2006 May 4;49(9):2681-8. DM4Z15M RU https://pubmed.ncbi.nlm.nih.gov/16640328 DM4Z15M DI DM4Z15M DM4Z15M DN 8-Octyl-benzolactam-V9 DM4Z15M MI TTRFOXJ DM4Z15M MN Protein kinase C gamma (PRKCG) DM4Z15M MT DTT DM4Z15M MA Inhibitor DM4Z15M RN Design and synthesis of 8-octyl-benzolactam-V9, a selective activator for protein kinase C epsilon and eta. J Med Chem. 2006 May 4;49(9):2681-8. DM4Z15M RU https://pubmed.ncbi.nlm.nih.gov/16640328 DM4QYEF DI DM4QYEF DM4QYEF DN 8-OH-MANZAMINE A DM4QYEF MI TTRSMW9 DM4QYEF MN Glycogen synthase kinase-3 beta (GSK-3B) DM4QYEF MT DTT DM4QYEF MA Inhibitor DM4QYEF RN Manzamine B and E and ircinal A related alkaloids from an Indonesian Acanthostrongylophora sponge and their activity against infectious, tropical p... J Nat Prod. 2006 Jul;69(7):1034-40. DM4QYEF RU https://pubmed.ncbi.nlm.nih.gov/16872140 DMXDQ25 DI DMXDQ25 DMXDQ25 DN 8-Oxo-8-phenyl-octanoic acid DMXDQ25 MI TTBH0VX DMXDQ25 MN Histone deacetylase (HDAC) DMXDQ25 MT DTT DMXDQ25 MA Inhibitor DMXDQ25 RN Inhibitors of human histone deacetylase: synthesis and enzyme and cellular activity of straight chain hydroxamates. J Med Chem. 2002 Feb 14;45(4):753-7. DMXDQ25 RU https://pubmed.ncbi.nlm.nih.gov/11831887 DMXDQ25 DI DMXDQ25 DMXDQ25 DN 8-Oxo-8-phenyl-octanoic acid DMXDQ25 MI TT6R7JZ DMXDQ25 MN Histone deacetylase 1 (HDAC1) DMXDQ25 MT DTT DMXDQ25 MA Inhibitor DMXDQ25 RN Inhibitors of human histone deacetylase: synthesis and enzyme and cellular activity of straight chain hydroxamates. J Med Chem. 2002 Feb 14;45(4):753-7. DMXDQ25 RU https://pubmed.ncbi.nlm.nih.gov/11831887 DMXDQ25 DI DMXDQ25 DMXDQ25 DN 8-Oxo-8-phenyl-octanoic acid DMXDQ25 MI TTYHPU6 DMXDQ25 MN Histone deacetylase 10 (HDAC10) DMXDQ25 MT DTT DMXDQ25 MA Inhibitor DMXDQ25 RN Inhibitors of human histone deacetylase: synthesis and enzyme and cellular activity of straight chain hydroxamates. J Med Chem. 2002 Feb 14;45(4):753-7. DMXDQ25 RU https://pubmed.ncbi.nlm.nih.gov/11831887 DMXDQ25 DI DMXDQ25 DMXDQ25 DN 8-Oxo-8-phenyl-octanoic acid DMXDQ25 MI TTSHTOI DMXDQ25 MN Histone deacetylase 2 (HDAC2) DMXDQ25 MT DTT DMXDQ25 MA Inhibitor DMXDQ25 RN Inhibitors of human histone deacetylase: synthesis and enzyme and cellular activity of straight chain hydroxamates. J Med Chem. 2002 Feb 14;45(4):753-7. DMXDQ25 RU https://pubmed.ncbi.nlm.nih.gov/11831887 DMXDQ25 DI DMXDQ25 DMXDQ25 DN 8-Oxo-8-phenyl-octanoic acid DMXDQ25 MI TTTQGH8 DMXDQ25 MN Histone deacetylase 4 (HDAC4) DMXDQ25 MT DTT DMXDQ25 MA Inhibitor DMXDQ25 RN Inhibitors of human histone deacetylase: synthesis and enzyme and cellular activity of straight chain hydroxamates. J Med Chem. 2002 Feb 14;45(4):753-7. DMXDQ25 RU https://pubmed.ncbi.nlm.nih.gov/11831887 DMXDQ25 DI DMXDQ25 DMXDQ25 DN 8-Oxo-8-phenyl-octanoic acid DMXDQ25 MI TT5ZKDI DMXDQ25 MN Histone deacetylase 6 (HDAC6) DMXDQ25 MT DTT DMXDQ25 MA Inhibitor DMXDQ25 RN Inhibitors of human histone deacetylase: synthesis and enzyme and cellular activity of straight chain hydroxamates. J Med Chem. 2002 Feb 14;45(4):753-7. DMXDQ25 RU https://pubmed.ncbi.nlm.nih.gov/11831887 DMXDQ25 DI DMXDQ25 DMXDQ25 DN 8-Oxo-8-phenyl-octanoic acid DMXDQ25 MI TTT6LFV DMXDQ25 MN Histone deacetylase 8 (HDAC8) DMXDQ25 MT DTT DMXDQ25 MA Inhibitor DMXDQ25 RN Inhibitors of human histone deacetylase: synthesis and enzyme and cellular activity of straight chain hydroxamates. J Med Chem. 2002 Feb 14;45(4):753-7. DMXDQ25 RU https://pubmed.ncbi.nlm.nih.gov/11831887 DMWM1UL DI DMWM1UL DMWM1UL DN 8-Oxo-8-phenyl-octanoic acid hydroxyamide DMWM1UL MI TTBH0VX DMWM1UL MN Histone deacetylase (HDAC) DMWM1UL MT DTT DMWM1UL MA Inhibitor DMWM1UL RN Histone deacetylase inhibitors. J Med Chem. 2003 Nov 20;46(24):5097-116. DMWM1UL RU https://pubmed.ncbi.nlm.nih.gov/14613312 DMWM1UL DI DMWM1UL DMWM1UL DN 8-Oxo-8-phenyl-octanoic acid hydroxyamide DMWM1UL MI TT6R7JZ DMWM1UL MN Histone deacetylase 1 (HDAC1) DMWM1UL MT DTT DMWM1UL MA Inhibitor DMWM1UL RN Histone deacetylase inhibitors. J Med Chem. 2003 Nov 20;46(24):5097-116. DMWM1UL RU https://pubmed.ncbi.nlm.nih.gov/14613312 DMWM1UL DI DMWM1UL DMWM1UL DN 8-Oxo-8-phenyl-octanoic acid hydroxyamide DMWM1UL MI TTSHTOI DMWM1UL MN Histone deacetylase 2 (HDAC2) DMWM1UL MT DTT DMWM1UL MA Inhibitor DMWM1UL RN Histone deacetylase inhibitors. J Med Chem. 2003 Nov 20;46(24):5097-116. DMWM1UL RU https://pubmed.ncbi.nlm.nih.gov/14613312 DMWM1UL DI DMWM1UL DMWM1UL DN 8-Oxo-8-phenyl-octanoic acid hydroxyamide DMWM1UL MI TTTQGH8 DMWM1UL MN Histone deacetylase 4 (HDAC4) DMWM1UL MT DTT DMWM1UL MA Inhibitor DMWM1UL RN Histone deacetylase inhibitors. J Med Chem. 2003 Nov 20;46(24):5097-116. DMWM1UL RU https://pubmed.ncbi.nlm.nih.gov/14613312 DMWM1UL DI DMWM1UL DMWM1UL DN 8-Oxo-8-phenyl-octanoic acid hydroxyamide DMWM1UL MI TT5ZKDI DMWM1UL MN Histone deacetylase 6 (HDAC6) DMWM1UL MT DTT DMWM1UL MA Inhibitor DMWM1UL RN Histone deacetylase inhibitors. J Med Chem. 2003 Nov 20;46(24):5097-116. DMWM1UL RU https://pubmed.ncbi.nlm.nih.gov/14613312 DME8S0R DI DME8S0R DME8S0R DN 8-Pentyloxy-quinolin-2-ylamine DME8S0R MI TTX4RTB DME8S0R MN Melanin-concentrating hormone receptor 1 (MCHR1) DME8S0R MT DTT DME8S0R MA Inhibitor DME8S0R RN Synthesis and evaluation of 2-amino-8-alkoxy quinolines as MCHr1 antagonists. Part 1. Bioorg Med Chem Lett. 2004 Oct 4;14(19):4873-7. DME8S0R RU https://pubmed.ncbi.nlm.nih.gov/15341942 DMFGUCY DI DMFGUCY DMFGUCY DN 8-PHENYL THEOPHYLLINE DMFGUCY MI TTK25J1 DMFGUCY MN Adenosine A1 receptor (ADORA1) DMFGUCY MT DTT DMFGUCY MA Inhibitor DMFGUCY RN 1H-imidazo[4,5-c]quinolin-4-amines: novel non-xanthine adenosine antagonists. J Med Chem. 1991 Mar;34(3):1202-6. DMFGUCY RU https://pubmed.ncbi.nlm.nih.gov/2002461 DMFGUCY DI DMFGUCY DMFGUCY DN 8-PHENYL THEOPHYLLINE DMFGUCY MI TTM2AOE DMFGUCY MN Adenosine A2a receptor (ADORA2A) DMFGUCY MT DTT DMFGUCY MA Inhibitor DMFGUCY RN 1H-imidazo[4,5-c]quinolin-4-amines: novel non-xanthine adenosine antagonists. J Med Chem. 1991 Mar;34(3):1202-6. DMFGUCY RU https://pubmed.ncbi.nlm.nih.gov/2002461 DMFGUCY DI DMFGUCY DMFGUCY DN 8-PHENYL THEOPHYLLINE DMFGUCY MI TTNE7KG DMFGUCY MN Adenosine A2b receptor (ADORA2B) DMFGUCY MT DTT DMFGUCY MA Inhibitor DMFGUCY RN 2-Alkynyl-8-aryl-9-methyladenines as novel adenosine receptor antagonists: their synthesis and structure-activity relationships toward hepatic gluc... J Med Chem. 2001 Jan 18;44(2):170-9. DMFGUCY RU https://pubmed.ncbi.nlm.nih.gov/11170626 DMFGUCY DI DMFGUCY DMFGUCY DN 8-PHENYL THEOPHYLLINE DMFGUCY MI TTJFY5U DMFGUCY MN Adenosine A3 receptor (ADORA3) DMFGUCY MT DTT DMFGUCY MA Inhibitor DMFGUCY RN Adenosine receptors: targets for future drugs. J Med Chem. 1982 Mar;25(3):197-207. DMFGUCY RU https://pubmed.ncbi.nlm.nih.gov/6279840 DMHQGOC DI DMHQGOC DMHQGOC DN 8-Phenyl-1-propyl-3,7-dihydro-purine-2,6-dione DMHQGOC MI TTK25J1 DMHQGOC MN Adenosine A1 receptor (ADORA1) DMHQGOC MT DTT DMHQGOC MA Inhibitor DMHQGOC RN Synthesis of paraxanthine analogs (1,7-disubstituted xanthines) and other xanthines unsubstituted at the 3-position: structure-activity relationshi... J Med Chem. 1993 Oct 29;36(22):3341-9. DMHQGOC RU https://pubmed.ncbi.nlm.nih.gov/8230124 DMHQGOC DI DMHQGOC DMHQGOC DN 8-Phenyl-1-propyl-3,7-dihydro-purine-2,6-dione DMHQGOC MI TTM2AOE DMHQGOC MN Adenosine A2a receptor (ADORA2A) DMHQGOC MT DTT DMHQGOC MA Inhibitor DMHQGOC RN Preparation, properties, reactions, and adenosine receptor affinities of sulfophenylxanthine nitrophenyl esters: toward the development of sulfonic... J Med Chem. 2004 Feb 12;47(4):1031-43. DMHQGOC RU https://pubmed.ncbi.nlm.nih.gov/14761205 DMHQGOC DI DMHQGOC DMHQGOC DN 8-Phenyl-1-propyl-3,7-dihydro-purine-2,6-dione DMHQGOC MI TTNE7KG DMHQGOC MN Adenosine A2b receptor (ADORA2B) DMHQGOC MT DTT DMHQGOC MA Inhibitor DMHQGOC RN Preparation, properties, reactions, and adenosine receptor affinities of sulfophenylxanthine nitrophenyl esters: toward the development of sulfonic... J Med Chem. 2004 Feb 12;47(4):1031-43. DMHQGOC RU https://pubmed.ncbi.nlm.nih.gov/14761205 DM29L4D DI DM29L4D DM29L4D DN 8-Phenyl-2-piperidin-1-yl-chromen-4-one DM29L4D MI TTK3PY9 DM29L4D MN DNA-dependent protein kinase catalytic (PRKDC) DM29L4D MT DTT DM29L4D MA Inhibitor DM29L4D RN Selective benzopyranone and pyrimido[2,1-a]isoquinolin-4-one inhibitors of DNA-dependent protein kinase: synthesis, structure-activity studies, and... J Med Chem. 2005 Jan 27;48(2):569-85. DM29L4D RU https://pubmed.ncbi.nlm.nih.gov/15658870 DMJMWOE DI DMJMWOE DMJMWOE DN 8-Phenyl-2-thiomorpholin-4-yl-chromen-4-one DMJMWOE MI TTK3PY9 DMJMWOE MN DNA-dependent protein kinase catalytic (PRKDC) DMJMWOE MT DTT DMJMWOE MA Inhibitor DMJMWOE RN Selective benzopyranone and pyrimido[2,1-a]isoquinolin-4-one inhibitors of DNA-dependent protein kinase: synthesis, structure-activity studies, and... J Med Chem. 2005 Jan 27;48(2):569-85. DMJMWOE RU https://pubmed.ncbi.nlm.nih.gov/15658870 DMJB1NI DI DMJB1NI DMJB1NI DN 8-Phenyl-3,7-dihydro-purine-2,6-dione DMJB1NI MI TTK25J1 DMJB1NI MN Adenosine A1 receptor (ADORA1) DMJB1NI MT DTT DMJB1NI MA Inhibitor DMJB1NI RN Synthesis of paraxanthine analogs (1,7-disubstituted xanthines) and other xanthines unsubstituted at the 3-position: structure-activity relationshi... J Med Chem. 1993 Oct 29;36(22):3341-9. DMJB1NI RU https://pubmed.ncbi.nlm.nih.gov/8230124 DM516NE DI DM516NE DM516NE DN 8-Phenyl-octanoic acid hydroxyamide DM516NE MI TT6R7JZ DM516NE MN Histone deacetylase 1 (HDAC1) DM516NE MT DTT DM516NE MA Inhibitor DM516NE RN A novel series of histone deacetylase inhibitors incorporating hetero aromatic ring systems as connection units. Bioorg Med Chem Lett. 2003 Nov 3;13(21):3817-20. DM516NE RU https://pubmed.ncbi.nlm.nih.gov/14552787 DM516NE DI DM516NE DM516NE DN 8-Phenyl-octanoic acid hydroxyamide DM516NE MI TTSHTOI DM516NE MN Histone deacetylase 2 (HDAC2) DM516NE MT DTT DM516NE MA Inhibitor DM516NE RN A novel series of histone deacetylase inhibitors incorporating hetero aromatic ring systems as connection units. Bioorg Med Chem Lett. 2003 Nov 3;13(21):3817-20. DM516NE RU https://pubmed.ncbi.nlm.nih.gov/14552787 DM4TWRJ DI DM4TWRJ DM4TWRJ DN 8-Phenyloctylcarbamic Acid Biphenyl-3-yl Ester DM4TWRJ MI TTDP1UC DM4TWRJ MN Fatty acid amide hydrolase (FAAH) DM4TWRJ MT DTT DM4TWRJ MA Inhibitor DM4TWRJ RN Synthesis and quantitative structure-activity relationship of fatty acid amide hydrolase inhibitors: modulation at the N-portion of biphenyl-3-yl a... J Med Chem. 2008 Jun 26;51(12):3487-98. DM4TWRJ RU https://pubmed.ncbi.nlm.nih.gov/18507372 DM958EN DI DM958EN DM958EN DN 8-Piperazin-1-yl-imidazo[1,2-a]pyrazine DM958EN MI TTNGILX DM958EN MN Adrenergic receptor alpha-1A (ADRA1A) DM958EN MT DTT DM958EN MA Inhibitor DM958EN RN Synthesis and hypoglycemic activity of substituted 8-(1-piperazinyl)imidazo[1,2-a]pyrazines. J Med Chem. 1992 Oct 16;35(21):3845-57. DM958EN RU https://pubmed.ncbi.nlm.nih.gov/1359141 DM958EN DI DM958EN DM958EN DN 8-Piperazin-1-yl-imidazo[1,2-a]pyrazine DM958EN MI TT34BHT DM958EN MN Adrenergic receptor alpha-1D (ADRA1D) DM958EN MT DTT DM958EN MA Inhibitor DM958EN RN Synthesis and hypoglycemic activity of substituted 8-(1-piperazinyl)imidazo[1,2-a]pyrazines. J Med Chem. 1992 Oct 16;35(21):3845-57. DM958EN RU https://pubmed.ncbi.nlm.nih.gov/1359141 DM2VC0E DI DM2VC0E DM2VC0E DN 8-prenylapigenin DM2VC0E MI TTJ0IQB DM2VC0E MN Phosphodiesterase 5A (PDE5A) DM2VC0E MT DTT DM2VC0E MA Inhibitor DM2VC0E RN Potent inhibition of human phosphodiesterase-5 by icariin derivatives. J Nat Prod. 2008 Sep;71(9):1513-7. DM2VC0E RU https://pubmed.ncbi.nlm.nih.gov/18778098 DMZC1SV DI DMZC1SV DMZC1SV DN 8-prenylquercetin DMZC1SV MI TTJ0IQB DMZC1SV MN Phosphodiesterase 5A (PDE5A) DMZC1SV MT DTT DMZC1SV MA Inhibitor DMZC1SV RN Potent inhibition of human phosphodiesterase-5 by icariin derivatives. J Nat Prod. 2008 Sep;71(9):1513-7. DMZC1SV RU https://pubmed.ncbi.nlm.nih.gov/18778098 DMKWYJX DI DMKWYJX DMKWYJX DN 8-Propionyl-7-propoxy-2H-chromen-2-one DMKWYJX MI TT2LVK8 DMKWYJX MN Carbonic anhydrase IX (CA-IX) DMKWYJX MT DTT DMKWYJX MA Inhibitor DMKWYJX RN 7,8-disubstituted- but not 6,7-disubstituted coumarins selectively inhibit the transmembrane, tumor-associated carbonic anhydrase isoforms IX and X... Bioorg Med Chem Lett. 2010 Dec 15;20(24):7255-8. DMKWYJX RU https://pubmed.ncbi.nlm.nih.gov/21067924 DM0TVL5 DI DM0TVL5 DM0TVL5 DN 8-Propoxy-quinolin-2-ylamine DM0TVL5 MI TTX4RTB DM0TVL5 MN Melanin-concentrating hormone receptor 1 (MCHR1) DM0TVL5 MT DTT DM0TVL5 MA Inhibitor DM0TVL5 RN Synthesis and evaluation of 2-amino-8-alkoxy quinolines as MCHr1 antagonists. Part 1. Bioorg Med Chem Lett. 2004 Oct 4;14(19):4873-7. DM0TVL5 RU https://pubmed.ncbi.nlm.nih.gov/15341942 DMT6YUF DI DMT6YUF DMT6YUF DN 8-propyl-2,6-diphenyl-9H-purine DMT6YUF MI TTK25J1 DMT6YUF MN Adenosine A1 receptor (ADORA1) DMT6YUF MT DTT DMT6YUF MA Inhibitor DMT6YUF RN 2,6-disubstituted and 2,6,8-trisubstituted purines as adenosine receptor antagonists. J Med Chem. 2006 May 18;49(10):2861-7. DMT6YUF RU https://pubmed.ncbi.nlm.nih.gov/16686529 DMT6YUF DI DMT6YUF DMT6YUF DN 8-propyl-2,6-diphenyl-9H-purine DMT6YUF MI TTM2AOE DMT6YUF MN Adenosine A2a receptor (ADORA2A) DMT6YUF MT DTT DMT6YUF MA Inhibitor DMT6YUF RN 2,6-disubstituted and 2,6,8-trisubstituted purines as adenosine receptor antagonists. J Med Chem. 2006 May 18;49(10):2861-7. DMT6YUF RU https://pubmed.ncbi.nlm.nih.gov/16686529 DMT6YUF DI DMT6YUF DMT6YUF DN 8-propyl-2,6-diphenyl-9H-purine DMT6YUF MI TTJFY5U DMT6YUF MN Adenosine A3 receptor (ADORA3) DMT6YUF MT DTT DMT6YUF MA Inhibitor DMT6YUF RN 2,6-disubstituted and 2,6,8-trisubstituted purines as adenosine receptor antagonists. J Med Chem. 2006 May 18;49(10):2861-7. DMT6YUF RU https://pubmed.ncbi.nlm.nih.gov/16686529 DM1I25F DI DM1I25F DM1I25F DN 8-Pyridin-4-yl-9H-purine-2,6-diamine DM1I25F MI TT9SL3Q DM1I25F MN Polypeptide deformylase (PDF) DM1I25F MT DTT DM1I25F MA Inhibitor DM1I25F RN Conformationally restricted analogues of trimethoprim: 2,6-diamino-8-substituted purines as potential dihydrofolate reductase inhibitors from Pneum... J Med Chem. 1997 Sep 12;40(19):3032-9. DM1I25F RU https://pubmed.ncbi.nlm.nih.gov/9301665 DML9HDA DI DML9HDA DML9HDA DN 8R-hydroxylobel-9-ene DML9HDA MI TTVBI8W DML9HDA MN Dopamine transporter (DAT) DML9HDA MT DTT DML9HDA MA Inhibitor DML9HDA RN Lobeline esters as novel ligands for neuronal nicotinic acetylcholine receptors and neurotransmitter transporters. Bioorg Med Chem. 2010 Jan 15;18(2):640-9. DML9HDA RU https://pubmed.ncbi.nlm.nih.gov/20036131 DML9HDA DI DML9HDA DML9HDA DN 8R-hydroxylobel-9-ene DML9HDA MI TT3ROYC DML9HDA MN Serotonin transporter (SERT) DML9HDA MT DTT DML9HDA MA Inhibitor DML9HDA RN Lobeline esters as novel ligands for neuronal nicotinic acetylcholine receptors and neurotransmitter transporters. Bioorg Med Chem. 2010 Jan 15;18(2):640-9. DML9HDA RU https://pubmed.ncbi.nlm.nih.gov/20036131 DMJ82TO DI DMJ82TO DMJ82TO DN 8R-hydroxylobelane DMJ82TO MI TTVBI8W DMJ82TO MN Dopamine transporter (DAT) DMJ82TO MT DTT DMJ82TO MA Inhibitor DMJ82TO RN Des-keto lobeline analogs with increased potency and selectivity at dopamine and serotonin transporters. Bioorg Med Chem Lett. 2006 Oct 1;16(19):5018-21. DMJ82TO RU https://pubmed.ncbi.nlm.nih.gov/16905316 DMJ82TO DI DMJ82TO DMJ82TO DN 8R-hydroxylobelane DMJ82TO MI TT3ROYC DMJ82TO MN Serotonin transporter (SERT) DMJ82TO MT DTT DMJ82TO MA Inhibitor DMJ82TO RN Des-keto lobeline analogs with increased potency and selectivity at dopamine and serotonin transporters. Bioorg Med Chem Lett. 2006 Oct 1;16(19):5018-21. DMJ82TO RU https://pubmed.ncbi.nlm.nih.gov/16905316 DMLK4WO DI DMLK4WO DMLK4WO DN 8R-Lisuride DMLK4WO MI TTTIBOJ DMLK4WO MN Histamine H1 receptor (H1R) DMLK4WO MT DTT DMLK4WO MA Agonist DMLK4WO RN 8R-lisuride is a potent stereospecific histamine H1-receptor partial agonist. Mol Pharmacol. 2004 Mar;65(3):538-49. DMLK4WO RU https://pubmed.ncbi.nlm.nih.gov/14978232 DMFPWJL DI DMFPWJL DMFPWJL DN 8-sec-Butoxy-quinolin-2-ylamine DMFPWJL MI TTX4RTB DMFPWJL MN Melanin-concentrating hormone receptor 1 (MCHR1) DMFPWJL MT DTT DMFPWJL MA Inhibitor DMFPWJL RN Synthesis and evaluation of 2-amino-8-alkoxy quinolines as MCHr1 antagonists. Part 1. Bioorg Med Chem Lett. 2004 Oct 4;14(19):4873-7. DMFPWJL RU https://pubmed.ncbi.nlm.nih.gov/15341942 DMT9SAC DI DMT9SAC DMT9SAC DN 8S-HETE DMT9SAC MI TTJ584C DMT9SAC MN Peroxisome proliferator-activated receptor alpha (PPARA) DMT9SAC MT DTT DMT9SAC MA Agonist DMT9SAC RN Differential activation of peroxisome proliferator-activated receptors by eicosanoids. J Biol Chem. 1995 Oct 13;270(41):23975-83. DMT9SAC RU https://pubmed.ncbi.nlm.nih.gov/7592593 DMRL3BK DI DMRL3BK DMRL3BK DN 8S-hydroxylobel-9-ene DMRL3BK MI TTVBI8W DMRL3BK MN Dopamine transporter (DAT) DMRL3BK MT DTT DMRL3BK MA Inhibitor DMRL3BK RN Des-keto lobeline analogs with increased potency and selectivity at dopamine and serotonin transporters. Bioorg Med Chem Lett. 2006 Oct 1;16(19):5018-21. DMRL3BK RU https://pubmed.ncbi.nlm.nih.gov/16905316 DMRL3BK DI DMRL3BK DMRL3BK DN 8S-hydroxylobel-9-ene DMRL3BK MI TT3ROYC DMRL3BK MN Serotonin transporter (SERT) DMRL3BK MT DTT DMRL3BK MA Inhibitor DMRL3BK RN Des-keto lobeline analogs with increased potency and selectivity at dopamine and serotonin transporters. Bioorg Med Chem Lett. 2006 Oct 1;16(19):5018-21. DMRL3BK RU https://pubmed.ncbi.nlm.nih.gov/16905316 DMLONTS DI DMLONTS DMLONTS DN 8S-hydroxylobelane DMLONTS MI TTVBI8W DMLONTS MN Dopamine transporter (DAT) DMLONTS MT DTT DMLONTS MA Inhibitor DMLONTS RN Des-keto lobeline analogs with increased potency and selectivity at dopamine and serotonin transporters. Bioorg Med Chem Lett. 2006 Oct 1;16(19):5018-21. DMLONTS RU https://pubmed.ncbi.nlm.nih.gov/16905316 DMLONTS DI DMLONTS DMLONTS DN 8S-hydroxylobelane DMLONTS MI TT3ROYC DMLONTS MN Serotonin transporter (SERT) DMLONTS MT DTT DMLONTS MA Inhibitor DMLONTS RN Des-keto lobeline analogs with increased potency and selectivity at dopamine and serotonin transporters. Bioorg Med Chem Lett. 2006 Oct 1;16(19):5018-21. DMLONTS RU https://pubmed.ncbi.nlm.nih.gov/16905316 DMOHB3Z DI DMOHB3Z DMOHB3Z DN 8-sulfophenyl theophylline DMOHB3Z MI TTSLI08 DMOHB3Z MN Adenosine receptor (ADOR) DMOHB3Z MT DTT DMOHB3Z MA Antagonist DMOHB3Z RN Minoxidil-induced hair growth is mediated by adenosine in cultured dermal papilla cells: possible involvement of sulfonylurea receptor 2B as a target of minoxidil. J Invest Dermatol. 2001 Dec;117(6):1594-600. DMOHB3Z RU https://pubmed.ncbi.nlm.nih.gov/11886528 DM4Y9U3 DI DM4Y9U3 DM4Y9U3 DN 9-(2-aminoethyl)-9,10-dihydroanthracene DM4Y9U3 MI TTJQOD7 DM4Y9U3 MN 5-HT 2A receptor (HTR2A) DM4Y9U3 MT DTT DM4Y9U3 MA Inhibitor DM4Y9U3 RN Synthesis, structure-affinity relationships, and modeling of AMDA analogs at 5-HT2A and H1 receptors: structural factors contributing to selectivity. Bioorg Med Chem. 2009 Sep 15;17(18):6496-504. DM4Y9U3 RU https://pubmed.ncbi.nlm.nih.gov/19700330 DM4Y9U3 DI DM4Y9U3 DM4Y9U3 DN 9-(2-aminoethyl)-9,10-dihydroanthracene DM4Y9U3 MI TTTIBOJ DM4Y9U3 MN Histamine H1 receptor (H1R) DM4Y9U3 MT DTT DM4Y9U3 MA Inhibitor DM4Y9U3 RN Synthesis, structure-affinity relationships, and modeling of AMDA analogs at 5-HT2A and H1 receptors: structural factors contributing to selectivity. Bioorg Med Chem. 2009 Sep 15;17(18):6496-504. DM4Y9U3 RU https://pubmed.ncbi.nlm.nih.gov/19700330 DMND39P DI DMND39P DMND39P DN 9-(2-aminopropyl)-9,10-dihydroanthracene DMND39P MI TTJQOD7 DMND39P MN 5-HT 2A receptor (HTR2A) DMND39P MT DTT DMND39P MA Inhibitor DMND39P RN Synthesis, structure-affinity relationships, and modeling of AMDA analogs at 5-HT2A and H1 receptors: structural factors contributing to selectivity. Bioorg Med Chem. 2009 Sep 15;17(18):6496-504. DMND39P RU https://pubmed.ncbi.nlm.nih.gov/19700330 DMND39P DI DMND39P DMND39P DN 9-(2-aminopropyl)-9,10-dihydroanthracene DMND39P MI TTTIBOJ DMND39P MN Histamine H1 receptor (H1R) DMND39P MT DTT DMND39P MA Inhibitor DMND39P RN Synthesis, structure-affinity relationships, and modeling of AMDA analogs at 5-HT2A and H1 receptors: structural factors contributing to selectivity. Bioorg Med Chem. 2009 Sep 15;17(18):6496-504. DMND39P RU https://pubmed.ncbi.nlm.nih.gov/19700330 DMYUMHG DI DMYUMHG DMYUMHG DN 9-(2-Hydroxyethyl)-9H-adenine DMYUMHG MI TTM2AOE DMYUMHG MN Adenosine A2a receptor (ADORA2A) DMYUMHG MT DTT DMYUMHG MA Inhibitor DMYUMHG RN 8-Bromo-9-alkyl adenine derivatives as tools for developing new adenosine A2A and A2B receptors ligands. Bioorg Med Chem. 2009 Apr 1;17(7):2812-22. DMYUMHG RU https://pubmed.ncbi.nlm.nih.gov/19282184 DM2UQ0R DI DM2UQ0R DM2UQ0R DN 9-(2-Hydroxypropyl)-9H-adenine DM2UQ0R MI TTM2AOE DM2UQ0R MN Adenosine A2a receptor (ADORA2A) DM2UQ0R MT DTT DM2UQ0R MA Inhibitor DM2UQ0R RN 8-Bromo-9-alkyl adenine derivatives as tools for developing new adenosine A2A and A2B receptors ligands. Bioorg Med Chem. 2009 Apr 1;17(7):2812-22. DM2UQ0R RU https://pubmed.ncbi.nlm.nih.gov/19282184 DMDYZCH DI DMDYZCH DMDYZCH DN 9-(3-aminobenzyl)-6-(furan-2-yl)-9H-purin-2-amine DMDYZCH MI TTK25J1 DMDYZCH MN Adenosine A1 receptor (ADORA1) DMDYZCH MT DTT DMDYZCH MA Inhibitor DMDYZCH RN Antagonists of the human adenosine A2A receptor. Part 3: Design and synthesis of pyrazolo[3,4-d]pyrimidines, pyrrolo[2,3-d]pyrimidines and 6-arylpu... Bioorg Med Chem Lett. 2008 May 1;18(9):2924-9. DMDYZCH RU https://pubmed.ncbi.nlm.nih.gov/18411049 DMDYZCH DI DMDYZCH DMDYZCH DN 9-(3-aminobenzyl)-6-(furan-2-yl)-9H-purin-2-amine DMDYZCH MI TTM2AOE DMDYZCH MN Adenosine A2a receptor (ADORA2A) DMDYZCH MT DTT DMDYZCH MA Inhibitor DMDYZCH RN Antagonists of the human adenosine A2A receptor. Part 3: Design and synthesis of pyrazolo[3,4-d]pyrimidines, pyrrolo[2,3-d]pyrimidines and 6-arylpu... Bioorg Med Chem Lett. 2008 May 1;18(9):2924-9. DMDYZCH RU https://pubmed.ncbi.nlm.nih.gov/18411049 DM51MRV DI DM51MRV DM51MRV DN 9-(3-aminopropoxy)-7H-furo[3,2-g]chromen-7-one DM51MRV MI TT3WG5C DM51MRV MN Monoamine oxidase type A (MAO-A) DM51MRV MT DTT DM51MRV MA Inhibitor DM51MRV RN A QSAR model for in silico screening of MAO-A inhibitors. Prediction, synthesis, and biological assay of novel coumarins. J Med Chem. 2006 Feb 9;49(3):1149-56. DM51MRV RU https://pubmed.ncbi.nlm.nih.gov/16451079 DM80MTI DI DM80MTI DM80MTI DN 9-(3-Hydroxypropyl)-9H-adenine DM80MTI MI TTM2AOE DM80MTI MN Adenosine A2a receptor (ADORA2A) DM80MTI MT DTT DM80MTI MA Inhibitor DM80MTI RN 8-Bromo-9-alkyl adenine derivatives as tools for developing new adenosine A2A and A2B receptors ligands. Bioorg Med Chem. 2009 Apr 1;17(7):2812-22. DM80MTI RU https://pubmed.ncbi.nlm.nih.gov/19282184 DMOP5AJ DI DMOP5AJ DMOP5AJ DN 9-(3-IODOBENZYLAMINO)-1,2,3,4-TETRAHYDROACRIDINE DMOP5AJ MI TTEB0GD DMOP5AJ MN Cholinesterase (BCHE) DMOP5AJ MT DTT DMOP5AJ MA Inhibitor DMOP5AJ RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DMOP5AJ RU https://pubmed.ncbi.nlm.nih.gov/10592235 DM4X18V DI DM4X18V DM4X18V DN 9-(3-nitrobenzyl)-6-(furan-2-yl)-9H-purin-2-amine DM4X18V MI TTK25J1 DM4X18V MN Adenosine A1 receptor (ADORA1) DM4X18V MT DTT DM4X18V MA Inhibitor DM4X18V RN Antagonists of the human adenosine A2A receptor. Part 3: Design and synthesis of pyrazolo[3,4-d]pyrimidines, pyrrolo[2,3-d]pyrimidines and 6-arylpu... Bioorg Med Chem Lett. 2008 May 1;18(9):2924-9. DM4X18V RU https://pubmed.ncbi.nlm.nih.gov/18411049 DM4X18V DI DM4X18V DM4X18V DN 9-(3-nitrobenzyl)-6-(furan-2-yl)-9H-purin-2-amine DM4X18V MI TTM2AOE DM4X18V MN Adenosine A2a receptor (ADORA2A) DM4X18V MT DTT DM4X18V MA Inhibitor DM4X18V RN Antagonists of the human adenosine A2A receptor. Part 3: Design and synthesis of pyrazolo[3,4-d]pyrimidines, pyrrolo[2,3-d]pyrimidines and 6-arylpu... Bioorg Med Chem Lett. 2008 May 1;18(9):2924-9. DM4X18V RU https://pubmed.ncbi.nlm.nih.gov/18411049 DMUIRS1 DI DMUIRS1 DMUIRS1 DN 9-(3-n-Pentylureido)non-4(Z)-enoic acid DMUIRS1 MI TT7WVHI DMUIRS1 MN Soluble epoxide hydrolase (EPHX2) DMUIRS1 MT DTT DMUIRS1 MA Inhibitor DMUIRS1 RN 14,15-Epoxyeicosa-5,8,11-trienoic acid (14,15-EET) surrogates containing epoxide bioisosteres: influence upon vascular relaxation and soluble epoxi... J Med Chem. 2009 Aug 27;52(16):5069-75. DMUIRS1 RU https://pubmed.ncbi.nlm.nih.gov/19653681 DMJYMFE DI DMJYMFE DMJYMFE DN 9-(3-n-Pentylureido)non-4-ynoic acid DMJYMFE MI TT7WVHI DMJYMFE MN Soluble epoxide hydrolase (EPHX2) DMJYMFE MT DTT DMJYMFE MA Inhibitor DMJYMFE RN 14,15-Epoxyeicosa-5,8,11-trienoic acid (14,15-EET) surrogates containing epoxide bioisosteres: influence upon vascular relaxation and soluble epoxi... J Med Chem. 2009 Aug 27;52(16):5069-75. DMJYMFE RU https://pubmed.ncbi.nlm.nih.gov/19653681 DMW2NY9 DI DMW2NY9 DMW2NY9 DN 9-(4-Fluoro-benzyl)-6-phenylsulfanyl-9H-purine DMW2NY9 MI TTQBR95 DMW2NY9 MN Stress-activated protein kinase 2a (p38 alpha) DMW2NY9 MT DTT DMW2NY9 MA Inhibitor DMW2NY9 RN Synthesis and biological testing of purine derivatives as potential ATP-competitive kinase inhibitors. J Med Chem. 2005 Feb 10;48(3):710-22. DMW2NY9 RU https://pubmed.ncbi.nlm.nih.gov/15689155 DMLKJD9 DI DMLKJD9 DMLKJD9 DN 9-(4-Hydroxybutyl)-N2-Phenylguanine DMLKJD9 MI TTP3QRF DMLKJD9 MN Thymidine kinase 1 (TK1) DMLKJD9 MT DTT DMLKJD9 MA Inhibitor DMLKJD9 RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMLKJD9 RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMOL01E DI DMOL01E DMOL01E DN 9-(4-Hydroxyphenyl)-2,7-Phenanthroline DMOL01E MI TT056SO DMOL01E MN Stress-activated protein kinase JNK3 (JNK3) DMOL01E MT DTT DMOL01E MA Inhibitor DMOL01E RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMOL01E RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMURKL9 DI DMURKL9 DMURKL9 DN 9-(4-nitrobenzyl)-6-(furan-2-yl)-9H-purin-2-amine DMURKL9 MI TTK25J1 DMURKL9 MN Adenosine A1 receptor (ADORA1) DMURKL9 MT DTT DMURKL9 MA Inhibitor DMURKL9 RN Antagonists of the human adenosine A2A receptor. Part 3: Design and synthesis of pyrazolo[3,4-d]pyrimidines, pyrrolo[2,3-d]pyrimidines and 6-arylpu... Bioorg Med Chem Lett. 2008 May 1;18(9):2924-9. DMURKL9 RU https://pubmed.ncbi.nlm.nih.gov/18411049 DMURKL9 DI DMURKL9 DMURKL9 DN 9-(4-nitrobenzyl)-6-(furan-2-yl)-9H-purin-2-amine DMURKL9 MI TTM2AOE DMURKL9 MN Adenosine A2a receptor (ADORA2A) DMURKL9 MT DTT DMURKL9 MA Inhibitor DMURKL9 RN Antagonists of the human adenosine A2A receptor. Part 3: Design and synthesis of pyrazolo[3,4-d]pyrimidines, pyrrolo[2,3-d]pyrimidines and 6-arylpu... Bioorg Med Chem Lett. 2008 May 1;18(9):2924-9. DMURKL9 RU https://pubmed.ncbi.nlm.nih.gov/18411049 DMGFQLE DI DMGFQLE DMGFQLE DN 9-(5,5-Difluoro-5-Phosphonopentyl)Guanine DMGFQLE MI TTMCF1Y DMGFQLE MN Purine nucleoside phosphorylase (PNP) DMGFQLE MT DTT DMGFQLE MA Inhibitor DMGFQLE RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMGFQLE RU https://pubmed.ncbi.nlm.nih.gov/17139284 DM6QDNH DI DM6QDNH DM6QDNH DN 9-(Aminomethyl)-9,10-dihydroanthracene DM6QDNH MI TTJQOD7 DM6QDNH MN 5-HT 2A receptor (HTR2A) DM6QDNH MT DTT DM6QDNH MA Inhibitor DM6QDNH RN Exploring the relationship between binding modes of 9-(aminomethyl)-9,10-dihydroanthracene and cyproheptadine analogues at the 5-HT2A serotonin rec... Bioorg Med Chem Lett. 2001 Feb 26;11(4):563-6. DM6QDNH RU https://pubmed.ncbi.nlm.nih.gov/11229772 DM6QDNH DI DM6QDNH DM6QDNH DN 9-(Aminomethyl)-9,10-dihydroanthracene DM6QDNH MI TTTIBOJ DM6QDNH MN Histamine H1 receptor (H1R) DM6QDNH MT DTT DM6QDNH MA Inhibitor DM6QDNH RN Synthesis, structure-affinity relationships, and modeling of AMDA analogs at 5-HT2A and H1 receptors: structural factors contributing to selectivity. Bioorg Med Chem. 2009 Sep 15;17(18):6496-504. DM6QDNH RU https://pubmed.ncbi.nlm.nih.gov/19700330 DMIY3D6 DI DMIY3D6 DMIY3D6 DN 9-(Biphenyl-4-yloxy)-1,1,1-trifluoro-nonan-2-one DMIY3D6 MI TTBH0VX DMIY3D6 MN Histone deacetylase (HDAC) DMIY3D6 MT DTT DMIY3D6 MA Inhibitor DMIY3D6 RN Histone deacetylase inhibitors. J Med Chem. 2003 Nov 20;46(24):5097-116. DMIY3D6 RU https://pubmed.ncbi.nlm.nih.gov/14613312 DMIY3D6 DI DMIY3D6 DMIY3D6 DN 9-(Biphenyl-4-yloxy)-1,1,1-trifluoro-nonan-2-one DMIY3D6 MI TT6R7JZ DMIY3D6 MN Histone deacetylase 1 (HDAC1) DMIY3D6 MT DTT DMIY3D6 MA Inhibitor DMIY3D6 RN Trifluoromethyl ketones as inhibitors of histone deacetylase. Bioorg Med Chem Lett. 2002 Dec 2;12(23):3443-7. DMIY3D6 RU https://pubmed.ncbi.nlm.nih.gov/12419380 DMIY3D6 DI DMIY3D6 DMIY3D6 DN 9-(Biphenyl-4-yloxy)-1,1,1-trifluoro-nonan-2-one DMIY3D6 MI TTYHPU6 DMIY3D6 MN Histone deacetylase 10 (HDAC10) DMIY3D6 MT DTT DMIY3D6 MA Inhibitor DMIY3D6 RN Histone deacetylase inhibitors. J Med Chem. 2003 Nov 20;46(24):5097-116. DMIY3D6 RU https://pubmed.ncbi.nlm.nih.gov/14613312 DMIY3D6 DI DMIY3D6 DMIY3D6 DN 9-(Biphenyl-4-yloxy)-1,1,1-trifluoro-nonan-2-one DMIY3D6 MI TTSHTOI DMIY3D6 MN Histone deacetylase 2 (HDAC2) DMIY3D6 MT DTT DMIY3D6 MA Inhibitor DMIY3D6 RN Trifluoromethyl ketones as inhibitors of histone deacetylase. Bioorg Med Chem Lett. 2002 Dec 2;12(23):3443-7. DMIY3D6 RU https://pubmed.ncbi.nlm.nih.gov/12419380 DMIY3D6 DI DMIY3D6 DMIY3D6 DN 9-(Biphenyl-4-yloxy)-1,1,1-trifluoro-nonan-2-one DMIY3D6 MI TTTQGH8 DMIY3D6 MN Histone deacetylase 4 (HDAC4) DMIY3D6 MT DTT DMIY3D6 MA Inhibitor DMIY3D6 RN Histone deacetylase inhibitors. J Med Chem. 2003 Nov 20;46(24):5097-116. DMIY3D6 RU https://pubmed.ncbi.nlm.nih.gov/14613312 DMIY3D6 DI DMIY3D6 DMIY3D6 DN 9-(Biphenyl-4-yloxy)-1,1,1-trifluoro-nonan-2-one DMIY3D6 MI TT5ZKDI DMIY3D6 MN Histone deacetylase 6 (HDAC6) DMIY3D6 MT DTT DMIY3D6 MA Inhibitor DMIY3D6 RN Histone deacetylase inhibitors. J Med Chem. 2003 Nov 20;46(24):5097-116. DMIY3D6 RU https://pubmed.ncbi.nlm.nih.gov/14613312 DMIY3D6 DI DMIY3D6 DMIY3D6 DN 9-(Biphenyl-4-yloxy)-1,1,1-trifluoro-nonan-2-one DMIY3D6 MI TTT6LFV DMIY3D6 MN Histone deacetylase 8 (HDAC8) DMIY3D6 MT DTT DMIY3D6 MA Inhibitor DMIY3D6 RN Histone deacetylase inhibitors. J Med Chem. 2003 Nov 20;46(24):5097-116. DMIY3D6 RU https://pubmed.ncbi.nlm.nih.gov/14613312 DMA2RCD DI DMA2RCD DMA2RCD DN 9-(N-benzylaminomethyl)-9,10-dihydroanthracene DMA2RCD MI TTJQOD7 DMA2RCD MN 5-HT 2A receptor (HTR2A) DMA2RCD MT DTT DMA2RCD MA Inhibitor DMA2RCD RN 9-Aminomethyl-9,10-dihydroanthracene (AMDA) analogs as structural probes for steric tolerance in 5-HT2A and H1 receptor binding sites. Bioorg Med Chem Lett. 2010 Feb 1;20(3):935-8. DMA2RCD RU https://pubmed.ncbi.nlm.nih.gov/20045641 DMFKVPA DI DMFKVPA DMFKVPA DN 9-(sec-Butyl)-9H-adenine DMFKVPA MI TTM2AOE DMFKVPA MN Adenosine A2a receptor (ADORA2A) DMFKVPA MT DTT DMFKVPA MA Inhibitor DMFKVPA RN 8-Bromo-9-alkyl adenine derivatives as tools for developing new adenosine A2A and A2B receptors ligands. Bioorg Med Chem. 2009 Apr 1;17(7):2812-22. DMFKVPA RU https://pubmed.ncbi.nlm.nih.gov/19282184 DMFKVPA DI DMFKVPA DMFKVPA DN 9-(sec-Butyl)-9H-adenine DMFKVPA MI TTNE7KG DMFKVPA MN Adenosine A2b receptor (ADORA2B) DMFKVPA MT DTT DMFKVPA MA Inhibitor DMFKVPA RN 8-Bromo-9-alkyl adenine derivatives as tools for developing new adenosine A2A and A2B receptors ligands. Bioorg Med Chem. 2009 Apr 1;17(7):2812-22. DMFKVPA RU https://pubmed.ncbi.nlm.nih.gov/19282184 DMVBCID DI DMVBCID DMVBCID DN 9,9,9-Trifluoro-8-oxo-nonanoic acid phenylamide DMVBCID MI TTBH0VX DMVBCID MN Histone deacetylase (HDAC) DMVBCID MT DTT DMVBCID MA Inhibitor DMVBCID RN Histone deacetylase inhibitors. J Med Chem. 2003 Nov 20;46(24):5097-116. DMVBCID RU https://pubmed.ncbi.nlm.nih.gov/14613312 DMVBCID DI DMVBCID DMVBCID DN 9,9,9-Trifluoro-8-oxo-nonanoic acid phenylamide DMVBCID MI TT6R7JZ DMVBCID MN Histone deacetylase 1 (HDAC1) DMVBCID MT DTT DMVBCID MA Inhibitor DMVBCID RN Trifluoromethyl ketones as inhibitors of histone deacetylase. Bioorg Med Chem Lett. 2002 Dec 2;12(23):3443-7. DMVBCID RU https://pubmed.ncbi.nlm.nih.gov/12419380 DMVBCID DI DMVBCID DMVBCID DN 9,9,9-Trifluoro-8-oxo-nonanoic acid phenylamide DMVBCID MI TTYHPU6 DMVBCID MN Histone deacetylase 10 (HDAC10) DMVBCID MT DTT DMVBCID MA Inhibitor DMVBCID RN Histone deacetylase inhibitors. J Med Chem. 2003 Nov 20;46(24):5097-116. DMVBCID RU https://pubmed.ncbi.nlm.nih.gov/14613312 DMVBCID DI DMVBCID DMVBCID DN 9,9,9-Trifluoro-8-oxo-nonanoic acid phenylamide DMVBCID MI TTSHTOI DMVBCID MN Histone deacetylase 2 (HDAC2) DMVBCID MT DTT DMVBCID MA Inhibitor DMVBCID RN Trifluoromethyl ketones as inhibitors of histone deacetylase. Bioorg Med Chem Lett. 2002 Dec 2;12(23):3443-7. DMVBCID RU https://pubmed.ncbi.nlm.nih.gov/12419380 DMVBCID DI DMVBCID DMVBCID DN 9,9,9-Trifluoro-8-oxo-nonanoic acid phenylamide DMVBCID MI TTTQGH8 DMVBCID MN Histone deacetylase 4 (HDAC4) DMVBCID MT DTT DMVBCID MA Inhibitor DMVBCID RN Histone deacetylase inhibitors. J Med Chem. 2003 Nov 20;46(24):5097-116. DMVBCID RU https://pubmed.ncbi.nlm.nih.gov/14613312 DMVBCID DI DMVBCID DMVBCID DN 9,9,9-Trifluoro-8-oxo-nonanoic acid phenylamide DMVBCID MI TT5ZKDI DMVBCID MN Histone deacetylase 6 (HDAC6) DMVBCID MT DTT DMVBCID MA Inhibitor DMVBCID RN Histone deacetylase inhibitors. J Med Chem. 2003 Nov 20;46(24):5097-116. DMVBCID RU https://pubmed.ncbi.nlm.nih.gov/14613312 DMVBCID DI DMVBCID DMVBCID DN 9,9,9-Trifluoro-8-oxo-nonanoic acid phenylamide DMVBCID MI TTT6LFV DMVBCID MN Histone deacetylase 8 (HDAC8) DMVBCID MT DTT DMVBCID MA Inhibitor DMVBCID RN Histone deacetylase inhibitors. J Med Chem. 2003 Nov 20;46(24):5097-116. DMVBCID RU https://pubmed.ncbi.nlm.nih.gov/14613312 DMOGD42 DI DMOGD42 DMOGD42 DN 9-[2-(1-Phosphonobutan-2-yloxy)ethyl]guanine DMOGD42 MI TTBL49X DMOGD42 MN Plasmodium Hypoxanthine-guanine phosphoribosyltransferase (Malaria LACZ) DMOGD42 MT DTT DMOGD42 MA Inhibitor DMOGD42 RN Synthesis of branched 9-[2-(2-phosphonoethoxy)ethyl]purines as a new class of acyclic nucleoside phosphonates which inhibit Plasmodium falciparum h... Bioorg Med Chem. 2009 Sep 1;17(17):6218-32. DMOGD42 RU https://pubmed.ncbi.nlm.nih.gov/19666228 DMKHXT9 DI DMKHXT9 DMKHXT9 DN 9-[2-(1-Phosphonobutan-2-yloxy)ethyl]hypoxanthine DMKHXT9 MI TTBL49X DMKHXT9 MN Plasmodium Hypoxanthine-guanine phosphoribosyltransferase (Malaria LACZ) DMKHXT9 MT DTT DMKHXT9 MA Inhibitor DMKHXT9 RN Synthesis of branched 9-[2-(2-phosphonoethoxy)ethyl]purines as a new class of acyclic nucleoside phosphonates which inhibit Plasmodium falciparum h... Bioorg Med Chem. 2009 Sep 1;17(17):6218-32. DMKHXT9 RU https://pubmed.ncbi.nlm.nih.gov/19666228 DMCXN6R DI DMCXN6R DMCXN6R DN 9-[2-(1-Phosphonopropan-2-yloxy)ethyl]guanine DMCXN6R MI TTBL49X DMCXN6R MN Plasmodium Hypoxanthine-guanine phosphoribosyltransferase (Malaria LACZ) DMCXN6R MT DTT DMCXN6R MA Inhibitor DMCXN6R RN Synthesis of branched 9-[2-(2-phosphonoethoxy)ethyl]purines as a new class of acyclic nucleoside phosphonates which inhibit Plasmodium falciparum h... Bioorg Med Chem. 2009 Sep 1;17(17):6218-32. DMCXN6R RU https://pubmed.ncbi.nlm.nih.gov/19666228 DMFR3SD DI DMFR3SD DMFR3SD DN 9-[5-(beta-Carboline-9-yl)pentyl]-beta-carboline DMFR3SD MI TTEB0GD DMFR3SD MN Cholinesterase (BCHE) DMFR3SD MT DTT DMFR3SD MA Inhibitor DMFR3SD RN Bivalent beta-carbolines as potential multitarget anti-Alzheimer agents. J Med Chem. 2010 May 13;53(9):3611-7. DMFR3SD RU https://pubmed.ncbi.nlm.nih.gov/20361801 DM6M5A4 DI DM6M5A4 DM6M5A4 DN 9-[9-(beta-Carboline-9-yl)nonyl]-beta-carboline DM6M5A4 MI TTEB0GD DM6M5A4 MN Cholinesterase (BCHE) DM6M5A4 MT DTT DM6M5A4 MA Inhibitor DM6M5A4 RN Bivalent beta-carbolines as potential multitarget anti-Alzheimer agents. J Med Chem. 2010 May 13;53(9):3611-7. DM6M5A4 RU https://pubmed.ncbi.nlm.nih.gov/20361801 DMJ1VAE DI DMJ1VAE DMJ1VAE DN 98mTc-CIM-ANT DMJ1VAE MI TTZ6T9E DMJ1VAE MN Somatostatin receptor type 2 (SSTR2) DMJ1VAE MT DTT DMJ1VAE MA Antagonist DMJ1VAE RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 356). DMJ1VAE RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=356 DMAGTL1 DI DMAGTL1 DMAGTL1 DN 99mTc-EC-0652 DMAGTL1 MI TT9G4N0 DMAGTL1 MN Glutamate carboxypeptidase II (GCPII) DMAGTL1 MT DTT DMAGTL1 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1606). DMAGTL1 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1606 DMQOFX2 DI DMQOFX2 DMQOFX2 DN 99mTc-MIP-1340 DMQOFX2 MI TT9G4N0 DMQOFX2 MN Glutamate carboxypeptidase II (GCPII) DMQOFX2 MT DTT DMQOFX2 MA Modulator DMQOFX2 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1606). DMQOFX2 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1606 DMYPD5L DI DMYPD5L DMYPD5L DN 99mTc-MIP-1407 DMYPD5L MI TTIND6G DMYPD5L MN Somatostatin receptor type 1 (SSTR1) DMYPD5L MT DTT DMYPD5L MA Modulator DMYPD5L RN Nat Rev Drug Discov. 2013 Feb;12(2):87-90. DMYPD5L RU https://pubmed.ncbi.nlm.nih.gov/23370234 DMYPD5L DI DMYPD5L DMYPD5L DN 99mTc-MIP-1407 DMYPD5L MI TTZ6T9E DMYPD5L MN Somatostatin receptor type 2 (SSTR2) DMYPD5L MT DTT DMYPD5L MA Modulator DMYPD5L RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 356). DMYPD5L RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=356 DMYPD5L DI DMYPD5L DMYPD5L DN 99mTc-MIP-1407 DMYPD5L MI TTJX3UE DMYPD5L MN Somatostatin receptor type 3 (SSTR3) DMYPD5L MT DTT DMYPD5L MA Modulator DMYPD5L RN Nat Rev Drug Discov. 2013 Feb;12(2):87-90. DMYPD5L RU https://pubmed.ncbi.nlm.nih.gov/23370234 DMYPD5L DI DMYPD5L DMYPD5L DN 99mTc-MIP-1407 DMYPD5L MI TTAE1BR DMYPD5L MN Somatostatin receptor type 4 (SSTR4) DMYPD5L MT DTT DMYPD5L MA Modulator DMYPD5L RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 358). DMYPD5L RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=358 DMYPD5L DI DMYPD5L DMYPD5L DN 99mTc-MIP-1407 DMYPD5L MI TT2BC4G DMYPD5L MN Somatostatin receptor type 5 (SSTR5) DMYPD5L MT DTT DMYPD5L MA Modulator DMYPD5L RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 359). DMYPD5L RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=359 DM8VZIY DI DM8VZIY DM8VZIY DN 9-Allyl-8-bromo-9H-adenine DM8VZIY MI TTK25J1 DM8VZIY MN Adenosine A1 receptor (ADORA1) DM8VZIY MT DTT DM8VZIY MA Inhibitor DM8VZIY RN 8-Bromo-9-alkyl adenine derivatives as tools for developing new adenosine A2A and A2B receptors ligands. Bioorg Med Chem. 2009 Apr 1;17(7):2812-22. DM8VZIY RU https://pubmed.ncbi.nlm.nih.gov/19282184 DM8VZIY DI DM8VZIY DM8VZIY DN 9-Allyl-8-bromo-9H-adenine DM8VZIY MI TTM2AOE DM8VZIY MN Adenosine A2a receptor (ADORA2A) DM8VZIY MT DTT DM8VZIY MA Inhibitor DM8VZIY RN 8-Bromo-9-alkyl adenine derivatives as tools for developing new adenosine A2A and A2B receptors ligands. Bioorg Med Chem. 2009 Apr 1;17(7):2812-22. DM8VZIY RU https://pubmed.ncbi.nlm.nih.gov/19282184 DM8VZIY DI DM8VZIY DM8VZIY DN 9-Allyl-8-bromo-9H-adenine DM8VZIY MI TTNE7KG DM8VZIY MN Adenosine A2b receptor (ADORA2B) DM8VZIY MT DTT DM8VZIY MA Inhibitor DM8VZIY RN 8-Bromo-9-alkyl adenine derivatives as tools for developing new adenosine A2A and A2B receptors ligands. Bioorg Med Chem. 2009 Apr 1;17(7):2812-22. DM8VZIY RU https://pubmed.ncbi.nlm.nih.gov/19282184 DMO9R6T DI DMO9R6T DMO9R6T DN 9alpha-acetoxy-miller-1(10)Z-enolide DMO9R6T MI TTSXVID DMO9R6T MN Nuclear factor NF-kappa-B (NFKB) DMO9R6T MT DTT DMO9R6T MA Inhibitor DMO9R6T RN Development of a structural model for NF-kappaB inhibition of sesquiterpene lactones using self-organizing neural networks. J Med Chem. 2006 Apr 6;49(7):2241-52. DMO9R6T RU https://pubmed.ncbi.nlm.nih.gov/16570920 DMNHZFG DI DMNHZFG DMNHZFG DN 9-Amino-1,2,3,4-tetrahydro-acridine-1,7-diol DMNHZFG MI TT1RS9F DMNHZFG MN Acetylcholinesterase (AChE) DMNHZFG MT DTT DMNHZFG MA Inhibitor DMNHZFG RN Synthesis and biological activity of putative mono-hydroxylated metabolites of velnacrine, Bioorg. Med. Chem. Lett. 2(8):865-870 (1992). DMNHZFG RU http://www.sciencedirect.com/science/article/pii/S0960894X00805466 DMUL6QR DI DMUL6QR DMUL6QR DN 9-Amino-6H,11H-indeno[1,2-c]isoquinolin-5-one DMUL6QR MI TTVDSZ0 DMUL6QR MN Poly [ADP-ribose] polymerase 1 (PARP1) DMUL6QR MT DTT DMUL6QR MA Inhibitor DMUL6QR RN Discovery of potent poly(ADP-ribose) polymerase-1 inhibitors from the modification of indeno[1,2-c]isoquinolinone. J Med Chem. 2005 Aug 11;48(16):5100-3. DMUL6QR RU https://pubmed.ncbi.nlm.nih.gov/16078828 DMNMVCZ DI DMNMVCZ DMNMVCZ DN 9-amino-7H-dibenzo[de,h]quinolin-7-one DMNMVCZ MI TT1RS9F DMNMVCZ MN Acetylcholinesterase (AChE) DMNMVCZ MT DTT DMNMVCZ MA Inhibitor DMNMVCZ RN Synthesis, biological evaluation and molecular modeling of oxoisoaporphine and oxoaporphine derivatives as new dual inhibitors of acetylcholinester... Eur J Med Chem. 2009 Jun;44(6):2523-32. DMNMVCZ RU https://pubmed.ncbi.nlm.nih.gov/19243862 DM9123M DI DM9123M DM9123M DN 9-Aminomethyl-9H-fluorene-2,5,6-triol DM9123M MI TTZFYLI DM9123M MN Dopamine D1 receptor (D1R) DM9123M MT DTT DM9123M MA Inhibitor DM9123M RN Synthesis and dopaminergic binding of 2-aryldopamine analogues: phenethylamines, 3-benzazepines, and 9-(aminomethyl)fluorenes. J Med Chem. 1986 Oct;29(10):1904-12. DM9123M RU https://pubmed.ncbi.nlm.nih.gov/3761310 DMNG6O7 DI DMNG6O7 DMNG6O7 DN 9-Aminomethyl-9H-fluorene-3,4-diol DMNG6O7 MI TTZFYLI DMNG6O7 MN Dopamine D1 receptor (D1R) DMNG6O7 MT DTT DMNG6O7 MA Inhibitor DMNG6O7 RN Synthesis and dopaminergic binding of 2-aryldopamine analogues: phenethylamines, 3-benzazepines, and 9-(aminomethyl)fluorenes. J Med Chem. 1986 Oct;29(10):1904-12. DMNG6O7 RU https://pubmed.ncbi.nlm.nih.gov/3761310 DMGCVT2 DI DMGCVT2 DMGCVT2 DN 9-anthroic acid DMGCVT2 MI TTOJI4S DMGCVT2 MN Calcium-dependent chloride channel anoctamin (ANO) DMGCVT2 MT DTT DMGCVT2 MA Blocker (channel blocker) DMGCVT2 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 708). DMGCVT2 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=708 DMGCVT2 DI DMGCVT2 DMGCVT2 DN 9-anthroic acid DMGCVT2 MI TTUYAF3 DMGCVT2 MN Chloride channel protein 1 (ClC-1) DMGCVT2 MT DTT DMGCVT2 MA Blocker (channel blocker) DMGCVT2 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 698). DMGCVT2 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=698 DMGCVT2 DI DMGCVT2 DMGCVT2 DN 9-anthroic acid DMGCVT2 MI TT0FC1V DMGCVT2 MN Volume regulated chloride channel (VRAC) DMGCVT2 MT DTT DMGCVT2 MA Blocker (channel blocker) DMGCVT2 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 710). DMGCVT2 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=710 DM8Q0D9 DI DM8Q0D9 DM8Q0D9 DN 9-Benzyl-6-(4-fluoro-phenylsulfanyl)-9H-purine DM8Q0D9 MI TTQBR95 DM8Q0D9 MN Stress-activated protein kinase 2a (p38 alpha) DM8Q0D9 MT DTT DM8Q0D9 MA Inhibitor DM8Q0D9 RN Synthesis and biological testing of purine derivatives as potential ATP-competitive kinase inhibitors. J Med Chem. 2005 Feb 10;48(3):710-22. DM8Q0D9 RU https://pubmed.ncbi.nlm.nih.gov/15689155 DM4JG60 DI DM4JG60 DM4JG60 DN 9-benzyl-6-(4-methylpiperazin-1-yl)-9H-purine DM4JG60 MI TTXJ178 DM4JG60 MN Histamine H4 receptor (H4R) DM4JG60 MT DTT DM4JG60 MA Inhibitor DM4JG60 RN 2,4-Diaminopyrimidines as histamine H4 receptor ligands--Scaffold optimization and pharmacological characterization. Bioorg Med Chem. 2009 Oct 15;17(20):7186-96. DM4JG60 RU https://pubmed.ncbi.nlm.nih.gov/19773175 DMNY5P1 DI DMNY5P1 DMNY5P1 DN 9-Benzyl-6-(4-nitro-benzylsulfanyl)-9H-purine DMNY5P1 MI TTLXAKE DMNY5P1 MN Solute carrier family 29 member 1 (SLC29A1) DMNY5P1 MT DTT DMNY5P1 MA Inhibitor DMNY5P1 RN Inhibition of nucleoside transport by new analogues of 4-nitrobenzylthioinosine: replacement of the ribose moiety by substituted benzyl groups. J Med Chem. 2004 Oct 21;47(22):5441-50. DMNY5P1 RU https://pubmed.ncbi.nlm.nih.gov/15481982 DMUMOE2 DI DMUMOE2 DMUMOE2 DN 9-benzyl-6-(benzylamino)-9H-purine-2-carbonitrile DMUMOE2 MI TT36ETB DMUMOE2 MN Cathepsin L (CTSL) DMUMOE2 MT DTT DMUMOE2 MA Inhibitor DMUMOE2 RN Development of potent purine-derived nitrile inhibitors of the trypanosomal protease TbcatB. J Med Chem. 2008 Feb 14;51(3):545-52. DMUMOE2 RU https://pubmed.ncbi.nlm.nih.gov/18173229 DMO6CB7 DI DMO6CB7 DMO6CB7 DN 9-benzyl-6-(furan-2-yl)-9H-purin-2-amine DMO6CB7 MI TTK25J1 DMO6CB7 MN Adenosine A1 receptor (ADORA1) DMO6CB7 MT DTT DMO6CB7 MA Inhibitor DMO6CB7 RN Antagonists of the human adenosine A2A receptor. Part 3: Design and synthesis of pyrazolo[3,4-d]pyrimidines, pyrrolo[2,3-d]pyrimidines and 6-arylpu... Bioorg Med Chem Lett. 2008 May 1;18(9):2924-9. DMO6CB7 RU https://pubmed.ncbi.nlm.nih.gov/18411049 DMO6CB7 DI DMO6CB7 DMO6CB7 DN 9-benzyl-6-(furan-2-yl)-9H-purin-2-amine DMO6CB7 MI TTM2AOE DMO6CB7 MN Adenosine A2a receptor (ADORA2A) DMO6CB7 MT DTT DMO6CB7 MA Inhibitor DMO6CB7 RN Antagonists of the human adenosine A2A receptor. Part 3: Design and synthesis of pyrazolo[3,4-d]pyrimidines, pyrrolo[2,3-d]pyrimidines and 6-arylpu... Bioorg Med Chem Lett. 2008 May 1;18(9):2924-9. DMO6CB7 RU https://pubmed.ncbi.nlm.nih.gov/18411049 DMNCL5G DI DMNCL5G DMNCL5G DN 9-Benzyl-6-phenylsulfanyl-9H-purine DMNCL5G MI TTQBR95 DMNCL5G MN Stress-activated protein kinase 2a (p38 alpha) DMNCL5G MT DTT DMNCL5G MA Inhibitor DMNCL5G RN Synthesis and biological testing of purine derivatives as potential ATP-competitive kinase inhibitors. J Med Chem. 2005 Feb 10;48(3):710-22. DMNCL5G RU https://pubmed.ncbi.nlm.nih.gov/15689155 DMMWGVI DI DMMWGVI DMMWGVI DN 9-Benzyl-8-bromo-9H-adenine DMMWGVI MI TTK25J1 DMMWGVI MN Adenosine A1 receptor (ADORA1) DMMWGVI MT DTT DMMWGVI MA Inhibitor DMMWGVI RN 8-Bromo-9-alkyl adenine derivatives as tools for developing new adenosine A2A and A2B receptors ligands. Bioorg Med Chem. 2009 Apr 1;17(7):2812-22. DMMWGVI RU https://pubmed.ncbi.nlm.nih.gov/19282184 DMMWGVI DI DMMWGVI DMMWGVI DN 9-Benzyl-8-bromo-9H-adenine DMMWGVI MI TTM2AOE DMMWGVI MN Adenosine A2a receptor (ADORA2A) DMMWGVI MT DTT DMMWGVI MA Inhibitor DMMWGVI RN 8-Bromo-9-alkyl adenine derivatives as tools for developing new adenosine A2A and A2B receptors ligands. Bioorg Med Chem. 2009 Apr 1;17(7):2812-22. DMMWGVI RU https://pubmed.ncbi.nlm.nih.gov/19282184 DMONCUL DI DMONCUL DMONCUL DN 9-BENZYL-9H-ADENINE DMONCUL MI TTM2AOE DMONCUL MN Adenosine A2a receptor (ADORA2A) DMONCUL MT DTT DMONCUL MA Inhibitor DMONCUL RN 8-Bromo-9-alkyl adenine derivatives as tools for developing new adenosine A2A and A2B receptors ligands. Bioorg Med Chem. 2009 Apr 1;17(7):2812-22. DMONCUL RU https://pubmed.ncbi.nlm.nih.gov/19282184 DMQEO7F DI DMQEO7F DMQEO7F DN 9-Bromo-5,11-dimethyl-6H-pyrido[4,3-b]carbazole DMQEO7F MI TTX41N9 DMQEO7F MN Tyrosine-protein kinase Kit (KIT) DMQEO7F MT DTT DMQEO7F MA Inhibitor DMQEO7F RN Molecular modeling of wild-type and D816V c-Kit inhibition based on ATP-competitive binding of ellipticine derivatives to tyrosine kinases. J Med Chem. 2005 Oct 6;48(20):6194-201. DMQEO7F RU https://pubmed.ncbi.nlm.nih.gov/16190746 DMSWQY7 DI DMSWQY7 DMSWQY7 DN 9-But-3-enyl-9H-adenine DMSWQY7 MI TTM2AOE DMSWQY7 MN Adenosine A2a receptor (ADORA2A) DMSWQY7 MT DTT DMSWQY7 MA Inhibitor DMSWQY7 RN 8-Bromo-9-alkyl adenine derivatives as tools for developing new adenosine A2A and A2B receptors ligands. Bioorg Med Chem. 2009 Apr 1;17(7):2812-22. DMSWQY7 RU https://pubmed.ncbi.nlm.nih.gov/19282184 DMXU90T DI DMXU90T DMXU90T DN 9-Butyl-8-(3-Methoxybenzyl)-9h-Purin-6-Amine DMXU90T MI TT78R5H DMXU90T MN Heat shock protein 90 alpha (HSP90A) DMXU90T MT DTT DMXU90T MA Inhibitor DMXU90T RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DMXU90T RU https://pubmed.ncbi.nlm.nih.gov/10592235 DMKHPAE DI DMKHPAE DMKHPAE DN 9-Butyl-8-(4-Methoxybenzyl)-9h-Purin-6-Amine DMKHPAE MI TT78R5H DMKHPAE MN Heat shock protein 90 alpha (HSP90A) DMKHPAE MT DTT DMKHPAE MA Inhibitor DMKHPAE RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DMKHPAE RU https://pubmed.ncbi.nlm.nih.gov/10592235 DMZQLBD DI DMZQLBD DMZQLBD DN 9-Butyl-9H-adenine DMZQLBD MI TTM2AOE DMZQLBD MN Adenosine A2a receptor (ADORA2A) DMZQLBD MT DTT DMZQLBD MA Inhibitor DMZQLBD RN 8-Bromo-9-alkyl adenine derivatives as tools for developing new adenosine A2A and A2B receptors ligands. Bioorg Med Chem. 2009 Apr 1;17(7):2812-22. DMZQLBD RU https://pubmed.ncbi.nlm.nih.gov/19282184 DMK5DUA DI DMK5DUA DMK5DUA DN 9-chloro-5H-6-thia-4,5-diaza-chrysene 6,6-dioxide DMK5DUA MI TTSXVID DMK5DUA MN Nuclear factor NF-kappa-B (NFKB) DMK5DUA MT DTT DMK5DUA MA Inhibitor DMK5DUA RN Identification of N-(quinolin-8-yl)benzenesulfonamides as agents capable of down-regulating NFkappaB activity within two separate high-throughput s... Bioorg Med Chem Lett. 2008 Jan 1;18(1):329-35. DMK5DUA RU https://pubmed.ncbi.nlm.nih.gov/18024113 DM6EFN2 DI DM6EFN2 DM6EFN2 DN 9-chlorobenzo[h]isoquinolin-1(2H)-one DM6EFN2 MI TTTU902 DM6EFN2 MN Checkpoint kinase-1 (CHK1) DM6EFN2 MT DTT DM6EFN2 MA Inhibitor DM6EFN2 RN Synthesis and evaluation of substituted benzoisoquinolinones as potent inhibitors of Chk1 kinase. Bioorg Med Chem Lett. 2007 Nov 15;17(22):6280-5. DM6EFN2 RU https://pubmed.ncbi.nlm.nih.gov/17900896 DM04QWX DI DM04QWX DM04QWX DN 9-Cyclobutyl-9H-adenine DM04QWX MI TTK25J1 DM04QWX MN Adenosine A1 receptor (ADORA1) DM04QWX MT DTT DM04QWX MA Inhibitor DM04QWX RN 8-Bromo-9-alkyl adenine derivatives as tools for developing new adenosine A2A and A2B receptors ligands. Bioorg Med Chem. 2009 Apr 1;17(7):2812-22. DM04QWX RU https://pubmed.ncbi.nlm.nih.gov/19282184 DM04QWX DI DM04QWX DM04QWX DN 9-Cyclobutyl-9H-adenine DM04QWX MI TTM2AOE DM04QWX MN Adenosine A2a receptor (ADORA2A) DM04QWX MT DTT DM04QWX MA Inhibitor DM04QWX RN 8-Bromo-9-alkyl adenine derivatives as tools for developing new adenosine A2A and A2B receptors ligands. Bioorg Med Chem. 2009 Apr 1;17(7):2812-22. DM04QWX RU https://pubmed.ncbi.nlm.nih.gov/19282184 DM04QWX DI DM04QWX DM04QWX DN 9-Cyclobutyl-9H-adenine DM04QWX MI TTNE7KG DM04QWX MN Adenosine A2b receptor (ADORA2B) DM04QWX MT DTT DM04QWX MA Inhibitor DM04QWX RN 8-Bromo-9-alkyl adenine derivatives as tools for developing new adenosine A2A and A2B receptors ligands. Bioorg Med Chem. 2009 Apr 1;17(7):2812-22. DM04QWX RU https://pubmed.ncbi.nlm.nih.gov/19282184 DMP8VM2 DI DMP8VM2 DMP8VM2 DN 9-Cycloheptyl-9H-adenine DMP8VM2 MI TTM2AOE DMP8VM2 MN Adenosine A2a receptor (ADORA2A) DMP8VM2 MT DTT DMP8VM2 MA Inhibitor DMP8VM2 RN 8-Bromo-9-alkyl adenine derivatives as tools for developing new adenosine A2A and A2B receptors ligands. Bioorg Med Chem. 2009 Apr 1;17(7):2812-22. DMP8VM2 RU https://pubmed.ncbi.nlm.nih.gov/19282184 DMSGU2L DI DMSGU2L DMSGU2L DN 9-Cyclopentyl-9H-adenine DMSGU2L MI TTK25J1 DMSGU2L MN Adenosine A1 receptor (ADORA1) DMSGU2L MT DTT DMSGU2L MA Inhibitor DMSGU2L RN N6,9-disubstituted adenines: potent, selective antagonists at the A1 adenosine receptor. J Med Chem. 1991 Sep;34(9):2877-82. DMSGU2L RU https://pubmed.ncbi.nlm.nih.gov/1895305 DMSGU2L DI DMSGU2L DMSGU2L DN 9-Cyclopentyl-9H-adenine DMSGU2L MI TTM2AOE DMSGU2L MN Adenosine A2a receptor (ADORA2A) DMSGU2L MT DTT DMSGU2L MA Inhibitor DMSGU2L RN 8-Bromo-9-alkyl adenine derivatives as tools for developing new adenosine A2A and A2B receptors ligands. Bioorg Med Chem. 2009 Apr 1;17(7):2812-22. DMSGU2L RU https://pubmed.ncbi.nlm.nih.gov/19282184 DMSGU2L DI DMSGU2L DMSGU2L DN 9-Cyclopentyl-9H-adenine DMSGU2L MI TTJFY5U DMSGU2L MN Adenosine A3 receptor (ADORA3) DMSGU2L MT DTT DMSGU2L MA Inhibitor DMSGU2L RN 8-Bromo-9-alkyl adenine derivatives as tools for developing new adenosine A2A and A2B receptors ligands. Bioorg Med Chem. 2009 Apr 1;17(7):2812-22. DMSGU2L RU https://pubmed.ncbi.nlm.nih.gov/19282184 DMAFCZL DI DMAFCZL DMAFCZL DN 9-Cyclopropyl-9H-adenine DMAFCZL MI TTM2AOE DMAFCZL MN Adenosine A2a receptor (ADORA2A) DMAFCZL MT DTT DMAFCZL MA Inhibitor DMAFCZL RN 8-Bromo-9-alkyl adenine derivatives as tools for developing new adenosine A2A and A2B receptors ligands. Bioorg Med Chem. 2009 Apr 1;17(7):2812-22. DMAFCZL RU https://pubmed.ncbi.nlm.nih.gov/19282184 DM68IPZ DI DM68IPZ DM68IPZ DN 9-Deazaguanine DM68IPZ MI TTBL49X DM68IPZ MN Plasmodium Hypoxanthine-guanine phosphoribosyltransferase (Malaria LACZ) DM68IPZ MT DTT DM68IPZ MA Inhibitor DM68IPZ RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DM68IPZ RU https://pubmed.ncbi.nlm.nih.gov/17139284 DM3G6LY DI DM3G6LY DM3G6LY DN 9-Deazahypoxanthine DM3G6LY MI TTMCF1Y DM3G6LY MN Purine nucleoside phosphorylase (PNP) DM3G6LY MT DTT DM3G6LY MA Inhibitor DM3G6LY RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DM3G6LY RU https://pubmed.ncbi.nlm.nih.gov/17139284 DME7ONQ DI DME7ONQ DME7ONQ DN 9-Deazainosine DME7ONQ MI TTMCF1Y DME7ONQ MN Purine nucleoside phosphorylase (PNP) DME7ONQ MT DTT DME7ONQ MA Inhibitor DME7ONQ RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DME7ONQ RU https://pubmed.ncbi.nlm.nih.gov/17139284 DM9BCDT DI DM9BCDT DM9BCDT DN 9-DEAZAINOSINE-2',3'-O-ETHYLIDENEPHOSPHONATE DM9BCDT MI TTMCF1Y DM9BCDT MN Purine nucleoside phosphorylase (PNP) DM9BCDT MT DTT DM9BCDT MA Inhibitor DM9BCDT RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DM9BCDT RU https://pubmed.ncbi.nlm.nih.gov/10592235 DM70MPJ DI DM70MPJ DM70MPJ DN 9-Ethyl-2-methyl-beta-carboline-2-ium iodide DM70MPJ MI TT1RS9F DM70MPJ MN Acetylcholinesterase (AChE) DM70MPJ MT DTT DM70MPJ MA Inhibitor DM70MPJ RN Bivalent beta-carbolines as potential multitarget anti-Alzheimer agents. J Med Chem. 2010 May 13;53(9):3611-7. DM70MPJ RU https://pubmed.ncbi.nlm.nih.gov/20361801 DM70MPJ DI DM70MPJ DM70MPJ DN 9-Ethyl-2-methyl-beta-carboline-2-ium iodide DM70MPJ MI TTEB0GD DM70MPJ MN Cholinesterase (BCHE) DM70MPJ MT DTT DM70MPJ MA Inhibitor DM70MPJ RN Bivalent beta-carbolines as potential multitarget anti-Alzheimer agents. J Med Chem. 2010 May 13;53(9):3611-7. DM70MPJ RU https://pubmed.ncbi.nlm.nih.gov/20361801 DMRVS2D DI DMRVS2D DMRVS2D DN 9-Ethyl-8-phenylethynyl-9H-purin-6-ylamine DMRVS2D MI TTK25J1 DMRVS2D MN Adenosine A1 receptor (ADORA1) DMRVS2D MT DTT DMRVS2D MA Inhibitor DMRVS2D RN Introduction of alkynyl chains on C-8 of adenosine led to very selective antagonists of the A(3) adenosine receptor. Bioorg Med Chem Lett. 2001 Jul 23;11(14):1931-4. DMRVS2D RU https://pubmed.ncbi.nlm.nih.gov/11459663 DMRVS2D DI DMRVS2D DMRVS2D DN 9-Ethyl-8-phenylethynyl-9H-purin-6-ylamine DMRVS2D MI TTM2AOE DMRVS2D MN Adenosine A2a receptor (ADORA2A) DMRVS2D MT DTT DMRVS2D MA Inhibitor DMRVS2D RN Introduction of alkynyl chains on C-8 of adenosine led to very selective antagonists of the A(3) adenosine receptor. Bioorg Med Chem Lett. 2001 Jul 23;11(14):1931-4. DMRVS2D RU https://pubmed.ncbi.nlm.nih.gov/11459663 DMRVS2D DI DMRVS2D DMRVS2D DN 9-Ethyl-8-phenylethynyl-9H-purin-6-ylamine DMRVS2D MI TTJFY5U DMRVS2D MN Adenosine A3 receptor (ADORA3) DMRVS2D MT DTT DMRVS2D MA Inhibitor DMRVS2D RN Introduction of alkynyl chains on C-8 of adenosine led to very selective antagonists of the A(3) adenosine receptor. Bioorg Med Chem Lett. 2001 Jul 23;11(14):1931-4. DMRVS2D RU https://pubmed.ncbi.nlm.nih.gov/11459663 DMWV8YX DI DMWV8YX DMWV8YX DN 9-Ethyl-9H-adenine DMWV8YX MI TTK25J1 DMWV8YX MN Adenosine A1 receptor (ADORA1) DMWV8YX MT DTT DMWV8YX MA Inhibitor DMWV8YX RN 8-Bromo-9-alkyl adenine derivatives as tools for developing new adenosine A2A and A2B receptors ligands. Bioorg Med Chem. 2009 Apr 1;17(7):2812-22. DMWV8YX RU https://pubmed.ncbi.nlm.nih.gov/19282184 DMWV8YX DI DMWV8YX DMWV8YX DN 9-Ethyl-9H-adenine DMWV8YX MI TTM2AOE DMWV8YX MN Adenosine A2a receptor (ADORA2A) DMWV8YX MT DTT DMWV8YX MA Inhibitor DMWV8YX RN 8-Bromo-9-alkyl adenine derivatives as tools for developing new adenosine A2A and A2B receptors ligands. Bioorg Med Chem. 2009 Apr 1;17(7):2812-22. DMWV8YX RU https://pubmed.ncbi.nlm.nih.gov/19282184 DMHKUO9 DI DMHKUO9 DMHKUO9 DN 9-Ethyl-beta-carboline DMHKUO9 MI TT1RS9F DMHKUO9 MN Acetylcholinesterase (AChE) DMHKUO9 MT DTT DMHKUO9 MA Inhibitor DMHKUO9 RN Bivalent beta-carbolines as potential multitarget anti-Alzheimer agents. J Med Chem. 2010 May 13;53(9):3611-7. DMHKUO9 RU https://pubmed.ncbi.nlm.nih.gov/20361801 DMLK0TX DI DMLK0TX DMLK0TX DN 9-fluoro-5H-6-thia-4,5-diaza-chrysene 6,6-dioxide DMLK0TX MI TTSXVID DMLK0TX MN Nuclear factor NF-kappa-B (NFKB) DMLK0TX MT DTT DMLK0TX MA Inhibitor DMLK0TX RN Identification of N-(quinolin-8-yl)benzenesulfonamides as agents capable of down-regulating NFkappaB activity within two separate high-throughput s... Bioorg Med Chem Lett. 2008 Jan 1;18(1):329-35. DMLK0TX RU https://pubmed.ncbi.nlm.nih.gov/18024113 DMGAE9Z DI DMGAE9Z DMGAE9Z DN 9-Fluoro-6H,11H-indeno[1,2-c]isoquinolin-5-one DMGAE9Z MI TTVDSZ0 DMGAE9Z MN Poly [ADP-ribose] polymerase 1 (PARP1) DMGAE9Z MT DTT DMGAE9Z MA Inhibitor DMGAE9Z RN Discovery of potent poly(ADP-ribose) polymerase-1 inhibitors from the modification of indeno[1,2-c]isoquinolinone. J Med Chem. 2005 Aug 11;48(16):5100-3. DMGAE9Z RU https://pubmed.ncbi.nlm.nih.gov/16078828 DMBWAMR DI DMBWAMR DMBWAMR DN 9H-beta-Carbolin-3-ol DMBWAMR MI TT1MPAY DMBWAMR MN GABA(A) receptor alpha-1 (GABRA1) DMBWAMR MT DTT DMBWAMR MA Inhibitor DMBWAMR RN Synthesis of novel 3-substituted beta-carbolines as benzodiazepine receptor ligands: probing the benzodiazepine receptor pharmacophore. J Med Chem. 1988 Sep;31(9):1854-61. DMBWAMR RU https://pubmed.ncbi.nlm.nih.gov/2842507 DMBWAMR DI DMBWAMR DMBWAMR DN 9H-beta-Carbolin-3-ol DMBWAMR MI TTNJYV2 DMBWAMR MN Gamma-aminobutyric acid receptor (GAR) DMBWAMR MT DTT DMBWAMR MA Inhibitor DMBWAMR RN Synthesis of novel 3-substituted beta-carbolines as benzodiazepine receptor ligands: probing the benzodiazepine receptor pharmacophore. J Med Chem. 1988 Sep;31(9):1854-61. DMBWAMR RU https://pubmed.ncbi.nlm.nih.gov/2842507 DMBLEI7 DI DMBLEI7 DMBLEI7 DN 9H-beta-Carbolin-6-ylamine DMBLEI7 MI TT1MPAY DMBLEI7 MN GABA(A) receptor alpha-1 (GABRA1) DMBLEI7 MT DTT DMBLEI7 MA Inhibitor DMBLEI7 RN Synthesis of 6-substituted beta-carbolines that behave as benzodiazepine receptor antagonists or inverse agonists. J Med Chem. 1987 Apr;30(4):750-3. DMBLEI7 RU https://pubmed.ncbi.nlm.nih.gov/3031296 DMBLEI7 DI DMBLEI7 DMBLEI7 DN 9H-beta-Carbolin-6-ylamine DMBLEI7 MI TTNJYV2 DMBLEI7 MN Gamma-aminobutyric acid receptor (GAR) DMBLEI7 MT DTT DMBLEI7 MA Inhibitor DMBLEI7 RN Synthesis of 6-substituted beta-carbolines that behave as benzodiazepine receptor antagonists or inverse agonists. J Med Chem. 1987 Apr;30(4):750-3. DMBLEI7 RU https://pubmed.ncbi.nlm.nih.gov/3031296 DMK459I DI DMK459I DMK459I DN 9H-beta-Carboline-3-carboxylic acid ethyl ester DMK459I MI TT1MPAY DMK459I MN GABA(A) receptor alpha-1 (GABRA1) DMK459I MT DTT DMK459I MA Inhibitor DMK459I RN Design, synthesis, and subtype selectivity of 3,6-disubstituted -carbolines at Bz/GABA(A)ergic receptors. SAR and studies directed toward agents f... Bioorg Med Chem. 2010 Nov 1;18(21):7548-64. DMK459I RU https://pubmed.ncbi.nlm.nih.gov/20888240 DMK459I DI DMK459I DMK459I DN 9H-beta-Carboline-3-carboxylic acid ethyl ester DMK459I MI TTBMV1G DMK459I MN GABA(A) receptor alpha-2 (GABRA2) DMK459I MT DTT DMK459I MA Inhibitor DMK459I RN Design, synthesis, and subtype selectivity of 3,6-disubstituted -carbolines at Bz/GABA(A)ergic receptors. SAR and studies directed toward agents f... Bioorg Med Chem. 2010 Nov 1;18(21):7548-64. DMK459I RU https://pubmed.ncbi.nlm.nih.gov/20888240 DMK459I DI DMK459I DMK459I DN 9H-beta-Carboline-3-carboxylic acid ethyl ester DMK459I MI TT37EDJ DMK459I MN GABA(A) receptor alpha-3 (GABRA3) DMK459I MT DTT DMK459I MA Inhibitor DMK459I RN Design, synthesis, and subtype selectivity of 3,6-disubstituted -carbolines at Bz/GABA(A)ergic receptors. SAR and studies directed toward agents f... Bioorg Med Chem. 2010 Nov 1;18(21):7548-64. DMK459I RU https://pubmed.ncbi.nlm.nih.gov/20888240 DMK459I DI DMK459I DMK459I DN 9H-beta-Carboline-3-carboxylic acid ethyl ester DMK459I MI TTNZPQ1 DMK459I MN GABA(A) receptor alpha-5 (GABRA5) DMK459I MT DTT DMK459I MA Inhibitor DMK459I RN Design, synthesis, and subtype selectivity of 3,6-disubstituted -carbolines at Bz/GABA(A)ergic receptors. SAR and studies directed toward agents f... Bioorg Med Chem. 2010 Nov 1;18(21):7548-64. DMK459I RU https://pubmed.ncbi.nlm.nih.gov/20888240 DMK459I DI DMK459I DMK459I DN 9H-beta-Carboline-3-carboxylic acid ethyl ester DMK459I MI TT06RH5 DMK459I MN GABA(A) receptor gamma-2 (GABRG2) DMK459I MT DTT DMK459I MA Inhibitor DMK459I RN Design, synthesis, and subtype selectivity of 3,6-disubstituted -carbolines at Bz/GABA(A)ergic receptors. SAR and studies directed toward agents f... Bioorg Med Chem. 2010 Nov 1;18(21):7548-64. DMK459I RU https://pubmed.ncbi.nlm.nih.gov/20888240 DMK459I DI DMK459I DMK459I DN 9H-beta-Carboline-3-carboxylic acid ethyl ester DMK459I MI TTNJYV2 DMK459I MN Gamma-aminobutyric acid receptor (GAR) DMK459I MT DTT DMK459I MA Inhibitor DMK459I RN Design, synthesis, and subtype selectivity of 3,6-disubstituted -carbolines at Bz/GABA(A)ergic receptors. SAR and studies directed toward agents f... Bioorg Med Chem. 2010 Nov 1;18(21):7548-64. DMK459I RU https://pubmed.ncbi.nlm.nih.gov/20888240 DMMUH98 DI DMMUH98 DMMUH98 DN 9H-beta-Carboline-3-carboxylic acid propyl ester DMMUH98 MI TT1MPAY DMMUH98 MN GABA(A) receptor alpha-1 (GABRA1) DMMUH98 MT DTT DMMUH98 MA Inhibitor DMMUH98 RN beta-Carbolines as benzodiazepine receptor ligands. 1. Synthesis and benzodiazepine receptor interaction of esters of beta-carboline-3-carboxylic a... J Med Chem. 1983 Apr;26(4):499-503. DMMUH98 RU https://pubmed.ncbi.nlm.nih.gov/6300400 DMMUH98 DI DMMUH98 DMMUH98 DN 9H-beta-Carboline-3-carboxylic acid propyl ester DMMUH98 MI TT06RH5 DMMUH98 MN GABA(A) receptor gamma-2 (GABRG2) DMMUH98 MT DTT DMMUH98 MA Inhibitor DMMUH98 RN beta-Carbolines as benzodiazepine receptor ligands. 1. Synthesis and benzodiazepine receptor interaction of esters of beta-carboline-3-carboxylic a... J Med Chem. 1983 Apr;26(4):499-503. DMMUH98 RU https://pubmed.ncbi.nlm.nih.gov/6300400 DMMUH98 DI DMMUH98 DMMUH98 DN 9H-beta-Carboline-3-carboxylic acid propyl ester DMMUH98 MI TTNJYV2 DMMUH98 MN Gamma-aminobutyric acid receptor (GAR) DMMUH98 MT DTT DMMUH98 MA Inhibitor DMMUH98 RN beta-Carbolines as benzodiazepine receptor ligands. 1. Synthesis and benzodiazepine receptor interaction of esters of beta-carboline-3-carboxylic a... J Med Chem. 1983 Apr;26(4):499-503. DMMUH98 RU https://pubmed.ncbi.nlm.nih.gov/6300400 DM6WHIA DI DM6WHIA DM6WHIA DN 9H-carbazole-2-carbaldehyde DM6WHIA MI TTBGTCW DM6WHIA MN Kinesin spindle messenger RNA (KIF11 mRNA) DM6WHIA MT DTT DM6WHIA MA Inhibitor DM6WHIA RN Kinesin spindle protein (KSP) inhibitors with 2,3-fused indole scaffolds. J Med Chem. 2010 Jul 8;53(13):5054-8. DM6WHIA RU https://pubmed.ncbi.nlm.nih.gov/20521839 DM0HNU3 DI DM0HNU3 DM0HNU3 DN 9H-carbazole-3-carbaldehyde DM0HNU3 MI TTBGTCW DM0HNU3 MN Kinesin spindle messenger RNA (KIF11 mRNA) DM0HNU3 MT DTT DM0HNU3 MA Inhibitor DM0HNU3 RN Kinesin spindle protein (KSP) inhibitors with 2,3-fused indole scaffolds. J Med Chem. 2010 Jul 8;53(13):5054-8. DM0HNU3 RU https://pubmed.ncbi.nlm.nih.gov/20521839 DMF1XLZ DI DMF1XLZ DMF1XLZ DN 9H-purine derivative DMF1XLZ MI TTJFY5U DMF1XLZ MN Adenosine A3 receptor (ADORA3) DMF1XLZ MT DTT DMF1XLZ MA Inhibitor DMF1XLZ RN 2-n-Butyl-9-methyl-8-[1,2,3]triazol-2-yl-9H-purin-6-ylamine and analogues as A2A adenosine receptor antagonists. Design, synthesis, and pharmacolog... J Med Chem. 2005 Nov 3;48(22):6887-96. DMF1XLZ RU https://pubmed.ncbi.nlm.nih.gov/16250647 DMOX21P DI DMOX21P DMOX21P DN 9-hydrazino-1,2,3,4-tetrahydroacridine DMOX21P MI TT1RS9F DMOX21P MN Acetylcholinesterase (AChE) DMOX21P MT DTT DMOX21P MA Inhibitor DMOX21P RN Novel heterobivalent tacrine derivatives as cholinesterase inhibitors with notable selectivity toward butyrylcholinesterase. J Med Chem. 2006 Dec 14;49(25):7540-4. DMOX21P RU https://pubmed.ncbi.nlm.nih.gov/17149883 DMH72MU DI DMH72MU DMH72MU DN 9-Hydroxy-7,8-benzoflavone DMH72MU MI TTSZLWK DMH72MU MN Aromatase (CYP19A1) DMH72MU MT DTT DMH72MU MA Inhibitor DMH72MU RN Pharmacophore modeling strategies for the development of novel nonsteroidal inhibitors of human aromatase (CYP19). Bioorg Med Chem Lett. 2010 May 15;20(10):3050-64. DMH72MU RU https://pubmed.ncbi.nlm.nih.gov/20413308 DM0FWNJ DI DM0FWNJ DM0FWNJ DN 9-hydroxyoctadecadienoic acid DM0FWNJ MI TTNBW4F DM0FWNJ MN G2 accumulation protein (GPR132) DM0FWNJ MT DTT DM0FWNJ MA Agonist DM0FWNJ RN Identification of 9-hydroxyoctadecadienoic acid and other oxidized free fatty acids as ligands of the G protein-coupled receptor G2A. J Biol Chem. 2005 Dec 9;280(49):40676-83. DM0FWNJ RU https://pubmed.ncbi.nlm.nih.gov/16236715 DM0FWNJ DI DM0FWNJ DM0FWNJ DN 9-hydroxyoctadecadienoic acid DM0FWNJ MI TTZMAO3 DM0FWNJ MN Peroxisome proliferator-activated receptor gamma (PPAR-gamma) DM0FWNJ MT DTT DM0FWNJ MA Inhibitor DM0FWNJ RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DM0FWNJ RU https://pubmed.ncbi.nlm.nih.gov/10592235 DMB9FCK DI DMB9FCK DMB9FCK DN 9-Hydroxypropyladenine, R-Isomer DMB9FCK MI TTP3QRF DMB9FCK MN Thymidine kinase 1 (TK1) DMB9FCK MT DTT DMB9FCK MA Inhibitor DMB9FCK RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMB9FCK RU https://pubmed.ncbi.nlm.nih.gov/17139284 DM8QJUH DI DM8QJUH DM8QJUH DN 9-Hydroxypropyladenine, S-Isomer DM8QJUH MI TTP3QRF DM8QJUH MN Thymidine kinase 1 (TK1) DM8QJUH MT DTT DM8QJUH MA Inhibitor DM8QJUH RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DM8QJUH RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMGCX7E DI DMGCX7E DMGCX7E DN 9-hydroxypyrrolo[3,4-c]carbazole-1,3(2H,6H)-dione DMGCX7E MI TTTU902 DMGCX7E MN Checkpoint kinase-1 (CHK1) DMGCX7E MT DTT DMGCX7E MA Inhibitor DMGCX7E RN 4-Phenylpyrrolo[3,4-c]carbazole-1,3(2H,6H)-dione inhibitors of the checkpoint kinase Wee1. Structure-activity relationships for chromophore modific... J Med Chem. 2006 Aug 10;49(16):4896-911. DMGCX7E RU https://pubmed.ncbi.nlm.nih.gov/16884302 DMGCX7E DI DMGCX7E DMGCX7E DN 9-hydroxypyrrolo[3,4-c]carbazole-1,3(2H,6H)-dione DMGCX7E MI TTJFOAL DMGCX7E MN Wee1-like protein kinase (WEE1) DMGCX7E MT DTT DMGCX7E MA Inhibitor DMGCX7E RN Receptor-based 3D-QSAR studies of checkpoint Wee1 kinase inhibitors. Eur J Med Chem. 2009 Apr;44(4):1383-95. DMGCX7E RU https://pubmed.ncbi.nlm.nih.gov/18976834 DMBQLAI DI DMBQLAI DMBQLAI DN 9-Isopropyl-9H-adenine DMBQLAI MI TTK25J1 DMBQLAI MN Adenosine A1 receptor (ADORA1) DMBQLAI MT DTT DMBQLAI MA Inhibitor DMBQLAI RN 8-Bromo-9-alkyl adenine derivatives as tools for developing new adenosine A2A and A2B receptors ligands. Bioorg Med Chem. 2009 Apr 1;17(7):2812-22. DMBQLAI RU https://pubmed.ncbi.nlm.nih.gov/19282184 DMBQLAI DI DMBQLAI DMBQLAI DN 9-Isopropyl-9H-adenine DMBQLAI MI TTM2AOE DMBQLAI MN Adenosine A2a receptor (ADORA2A) DMBQLAI MT DTT DMBQLAI MA Inhibitor DMBQLAI RN 8-Bromo-9-alkyl adenine derivatives as tools for developing new adenosine A2A and A2B receptors ligands. Bioorg Med Chem. 2009 Apr 1;17(7):2812-22. DMBQLAI RU https://pubmed.ncbi.nlm.nih.gov/19282184 DMBQLAI DI DMBQLAI DMBQLAI DN 9-Isopropyl-9H-adenine DMBQLAI MI TTNE7KG DMBQLAI MN Adenosine A2b receptor (ADORA2B) DMBQLAI MT DTT DMBQLAI MA Inhibitor DMBQLAI RN 8-Bromo-9-alkyl adenine derivatives as tools for developing new adenosine A2A and A2B receptors ligands. Bioorg Med Chem. 2009 Apr 1;17(7):2812-22. DMBQLAI RU https://pubmed.ncbi.nlm.nih.gov/19282184 DMW905K DI DMW905K DMW905K DN 9-mercapto-8-oxo-N-phenylnonanamide DMW905K MI TTT6LFV DMW905K MN Histone deacetylase 8 (HDAC8) DMW905K MT DTT DMW905K MA Inhibitor DMW905K RN Histone deacetylase inhibitors: from bench to clinic. J Med Chem. 2008 Mar 27;51(6):1505-29. DMW905K RU https://pubmed.ncbi.nlm.nih.gov/18247554 DMM2GQC DI DMM2GQC DMM2GQC DN 9-Mercaptomethyl-10-oxo-azecane-2-carboxylic acid DMM2GQC MI TT5TKPM DMM2GQC MN Neutral endopeptidase (MME) DMM2GQC MT DTT DMM2GQC MA Inhibitor DMM2GQC RN Design and synthesis of an orally active macrocyclic neutral endopeptidase 24.11 inhibitor. J Med Chem. 1993 Nov 26;36(24):3821-8. DMM2GQC RU https://pubmed.ncbi.nlm.nih.gov/8254611 DM1YK42 DI DM1YK42 DM1YK42 DN 9-Methoxy-1,2,3,4-tetrahydro-anthracen-2-ylamine DM1YK42 MI TTSQIFT DM1YK42 MN 5-HT 1A receptor (HTR1A) DM1YK42 MT DTT DM1YK42 MA Inhibitor DM1YK42 RN Synthesis of new derivatives of 8-OH-DPAT: Influence of substitution on the aromatic ring on the pharmacological profile, Bioorg. Med. Chem. Lett. 3(10):2035-2038 (1993). DM1YK42 RU http://www.sciencedirect.com/science/article/pii/S0960894X0181009X DMDW267 DI DMDW267 DMDW267 DN 9-Methoxy-5,11-dimethyl-6H-pyrido[4,3-b]carbazole DMDW267 MI TTX41N9 DMDW267 MN Tyrosine-protein kinase Kit (KIT) DMDW267 MT DTT DMDW267 MA Inhibitor DMDW267 RN Molecular modeling of wild-type and D816V c-Kit inhibition based on ATP-competitive binding of ellipticine derivatives to tyrosine kinases. J Med Chem. 2005 Oct 6;48(20):6194-201. DMDW267 RU https://pubmed.ncbi.nlm.nih.gov/16190746 DMKLTD5 DI DMKLTD5 DMKLTD5 DN 9-methyl-2-(trifluoromethyl)-9H-carbazole DMKLTD5 MI TTBGTCW DMKLTD5 MN Kinesin spindle messenger RNA (KIF11 mRNA) DMKLTD5 MT DTT DMKLTD5 MA Inhibitor DMKLTD5 RN Kinesin spindle protein (KSP) inhibitors with 2,3-fused indole scaffolds. J Med Chem. 2010 Jul 8;53(13):5054-8. DMKLTD5 RU https://pubmed.ncbi.nlm.nih.gov/20521839 DMF7QS5 DI DMF7QS5 DMF7QS5 DN 9-Methyl-2,3,4,9-tetrahydro-1H-beta-carboline DMF7QS5 MI TT3WG5C DMF7QS5 MN Monoamine oxidase type A (MAO-A) DMF7QS5 MT DTT DMF7QS5 MA Inhibitor DMF7QS5 RN Binding of beta-carbolines at imidazoline I2 receptors: a structure-affinity investigation. Bioorg Med Chem Lett. 2004 Feb 23;14(4):999-1002. DMF7QS5 RU https://pubmed.ncbi.nlm.nih.gov/15013009 DMF7QS5 DI DMF7QS5 DMF7QS5 DN 9-Methyl-2,3,4,9-tetrahydro-1H-beta-carboline DMF7QS5 MI TTGP7BY DMF7QS5 MN Monoamine oxidase type B (MAO-B) DMF7QS5 MT DTT DMF7QS5 MA Inhibitor DMF7QS5 RN Binding of beta-carbolines at imidazoline I2 receptors: a structure-affinity investigation. Bioorg Med Chem Lett. 2004 Feb 23;14(4):999-1002. DMF7QS5 RU https://pubmed.ncbi.nlm.nih.gov/15013009 DMKD0ZP DI DMKD0ZP DMKD0ZP DN 9-methyl-5H-6-thia-4,5-diaza-chrysene 6,6-dioxide DMKD0ZP MI TTSXVID DMKD0ZP MN Nuclear factor NF-kappa-B (NFKB) DMKD0ZP MT DTT DMKD0ZP MA Inhibitor DMKD0ZP RN Identification of N-(quinolin-8-yl)benzenesulfonamides as agents capable of down-regulating NFkappaB activity within two separate high-throughput s... Bioorg Med Chem Lett. 2008 Jan 1;18(1):329-35. DMKD0ZP RU https://pubmed.ncbi.nlm.nih.gov/18024113 DMO4CSP DI DMO4CSP DMO4CSP DN 9-Methyl-8-[1,2,3]triazol-2-yl-9H-purin-6-ylamine DMO4CSP MI TTK25J1 DMO4CSP MN Adenosine A1 receptor (ADORA1) DMO4CSP MT DTT DMO4CSP MA Inhibitor DMO4CSP RN 2-n-Butyl-9-methyl-8-[1,2,3]triazol-2-yl-9H-purin-6-ylamine and analogues as A2A adenosine receptor antagonists. Design, synthesis, and pharmacolog... J Med Chem. 2005 Nov 3;48(22):6887-96. DMO4CSP RU https://pubmed.ncbi.nlm.nih.gov/16250647 DMO4CSP DI DMO4CSP DMO4CSP DN 9-Methyl-8-[1,2,3]triazol-2-yl-9H-purin-6-ylamine DMO4CSP MI TTM2AOE DMO4CSP MN Adenosine A2a receptor (ADORA2A) DMO4CSP MT DTT DMO4CSP MA Inhibitor DMO4CSP RN 2-n-Butyl-9-methyl-8-[1,2,3]triazol-2-yl-9H-purin-6-ylamine and analogues as A2A adenosine receptor antagonists. Design, synthesis, and pharmacolog... J Med Chem. 2005 Nov 3;48(22):6887-96. DMO4CSP RU https://pubmed.ncbi.nlm.nih.gov/16250647 DM6DOVL DI DM6DOVL DM6DOVL DN 9-Methyl-9H-adenine DM6DOVL MI TTK25J1 DM6DOVL MN Adenosine A1 receptor (ADORA1) DM6DOVL MT DTT DM6DOVL MA Inhibitor DM6DOVL RN Novel amino acid derived natural products from the ascidian Atriolum robustum: identification and pharmacological characterization of a unique aden... J Med Chem. 2004 Apr 22;47(9):2243-55. DM6DOVL RU https://pubmed.ncbi.nlm.nih.gov/15084123 DM6DOVL DI DM6DOVL DM6DOVL DN 9-Methyl-9H-adenine DM6DOVL MI TTM2AOE DM6DOVL MN Adenosine A2a receptor (ADORA2A) DM6DOVL MT DTT DM6DOVL MA Inhibitor DM6DOVL RN 8-Bromo-9-alkyl adenine derivatives as tools for developing new adenosine A2A and A2B receptors ligands. Bioorg Med Chem. 2009 Apr 1;17(7):2812-22. DM6DOVL RU https://pubmed.ncbi.nlm.nih.gov/19282184 DM54FRI DI DM54FRI DM54FRI DN 9-Methylguanine DM54FRI MI TTG9CFY DM54FRI MN Bacterial Dihydroneopterinaldolase (Bact folB) DM54FRI MT DTT DM54FRI MA Inhibitor DM54FRI RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DM54FRI RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMPXLEU DI DMPXLEU DMPXLEU DN 9-N-ETHYL-8-ETHOXY-MANZAMINE A DMPXLEU MI TTRSMW9 DMPXLEU MN Glycogen synthase kinase-3 beta (GSK-3B) DMPXLEU MT DTT DMPXLEU MA Inhibitor DMPXLEU RN Glycogen synthase kinase-3 (GSK-3) inhibitory activity and structure-activity relationship (SAR) studies of the manzamine alkaloids. Potential for ... J Nat Prod. 2007 Sep;70(9):1397-405. DMPXLEU RU https://pubmed.ncbi.nlm.nih.gov/17708655 DM8LUYM DI DM8LUYM DM8LUYM DN 9-Nitropaullone DM8LUYM MI TTH6V3D DM8LUYM MN Cyclin-dependent kinase 1 (CDK1) DM8LUYM MT DTT DM8LUYM MA Inhibitor DM8LUYM RN Down-regulation of survivin in nitric oxide-induced cell growth inhibition and apoptosis of the human lung carcinoma cells. J Biol Chem. 2004 May 7;279(19):20267-76. DM8LUYM RU https://pubmed.ncbi.nlm.nih.gov/14988404 DM8LUYM DI DM8LUYM DM8LUYM DN 9-Nitropaullone DM8LUYM MI TT7HF4W DM8LUYM MN Cyclin-dependent kinase 2 (CDK2) DM8LUYM MT DTT DM8LUYM MA Inhibitor DM8LUYM RN Pharmacological inhibitors of cyclin-dependent kinases. Trends Pharmacol Sci. 2002 Sep;23(9):417-25. DM8LUYM RU https://pubmed.ncbi.nlm.nih.gov/12237154 DM8LUYM DI DM8LUYM DM8LUYM DN 9-Nitropaullone DM8LUYM MI TTL4Q97 DM8LUYM MN Cyclin-dependent kinase 5 (CDK5) DM8LUYM MT DTT DM8LUYM MA Inhibitor DM8LUYM RN Pharmacological inhibitors of cyclin-dependent kinases. Trends Pharmacol Sci. 2002 Sep;23(9):417-25. DM8LUYM RU https://pubmed.ncbi.nlm.nih.gov/12237154 DM1YUBX DI DM1YUBX DM1YUBX DN 9-N-METHYL-8-METHOXY-MANZAMINE A DM1YUBX MI TTRSMW9 DM1YUBX MN Glycogen synthase kinase-3 beta (GSK-3B) DM1YUBX MT DTT DM1YUBX MA Inhibitor DM1YUBX RN Glycogen synthase kinase-3 (GSK-3) inhibitory activity and structure-activity relationship (SAR) studies of the manzamine alkaloids. Potential for ... J Nat Prod. 2007 Sep;70(9):1397-405. DM1YUBX RU https://pubmed.ncbi.nlm.nih.gov/17708655 DMGMD1K DI DMGMD1K DMGMD1K DN 9-N-Phenylmethylamino-Tacrine DMGMD1K MI TTEB0GD DMGMD1K MN Cholinesterase (BCHE) DMGMD1K MT DTT DMGMD1K MA Inhibitor DMGMD1K RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMGMD1K RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMYXEJ8 DI DMYXEJ8 DMYXEJ8 DN 9-O-[2-(Phenylol-1-yloxy)ethyl]berberine bromide DMYXEJ8 MI TT1RS9F DMYXEJ8 MN Acetylcholinesterase (AChE) DMYXEJ8 MT DTT DMYXEJ8 MA Inhibitor DMYXEJ8 RN Synthesis, biological evaluation, and molecular modeling of berberine derivatives as potent acetylcholinesterase inhibitors. Bioorg Med Chem. 2010 Feb;18(3):1244-51. DMYXEJ8 RU https://pubmed.ncbi.nlm.nih.gov/20056426 DMYXEJ8 DI DMYXEJ8 DMYXEJ8 DN 9-O-[2-(Phenylol-1-yloxy)ethyl]berberine bromide DMYXEJ8 MI TTEB0GD DMYXEJ8 MN Cholinesterase (BCHE) DMYXEJ8 MT DTT DMYXEJ8 MA Inhibitor DMYXEJ8 RN Synthesis, biological evaluation, and molecular modeling of berberine derivatives as potent acetylcholinesterase inhibitors. Bioorg Med Chem. 2010 Feb;18(3):1244-51. DMYXEJ8 RU https://pubmed.ncbi.nlm.nih.gov/20056426 DM081G2 DI DM081G2 DM081G2 DN 9-O-[2-(Phenylol-1-yloxy)hexyl]berberine bromide DM081G2 MI TT1RS9F DM081G2 MN Acetylcholinesterase (AChE) DM081G2 MT DTT DM081G2 MA Inhibitor DM081G2 RN Synthesis, biological evaluation, and molecular modeling of berberine derivatives as potent acetylcholinesterase inhibitors. Bioorg Med Chem. 2010 Feb;18(3):1244-51. DM081G2 RU https://pubmed.ncbi.nlm.nih.gov/20056426 DM081G2 DI DM081G2 DM081G2 DN 9-O-[2-(Phenylol-1-yloxy)hexyl]berberine bromide DM081G2 MI TTEB0GD DM081G2 MN Cholinesterase (BCHE) DM081G2 MT DTT DM081G2 MA Inhibitor DM081G2 RN Synthesis, biological evaluation, and molecular modeling of berberine derivatives as potent acetylcholinesterase inhibitors. Bioorg Med Chem. 2010 Feb;18(3):1244-51. DM081G2 RU https://pubmed.ncbi.nlm.nih.gov/20056426 DMHRV2A DI DMHRV2A DMHRV2A DN 9-O-[3-(2-Pyridinoxyl)butyl]-berberine bromide DMHRV2A MI TT1RS9F DMHRV2A MN Acetylcholinesterase (AChE) DMHRV2A MT DTT DMHRV2A MA Inhibitor DMHRV2A RN Synthesis and biological evaluation of a new series of berberine derivatives as dual inhibitors of acetylcholinesterase and butyrylcholinesterase. Bioorg Med Chem. 2010 Jun 15;18(12):4475-84. DMHRV2A RU https://pubmed.ncbi.nlm.nih.gov/20471843 DMHRV2A DI DMHRV2A DMHRV2A DN 9-O-[3-(2-Pyridinoxyl)butyl]-berberine bromide DMHRV2A MI TTEB0GD DMHRV2A MN Cholinesterase (BCHE) DMHRV2A MT DTT DMHRV2A MA Inhibitor DMHRV2A RN Synthesis and biological evaluation of a new series of berberine derivatives as dual inhibitors of acetylcholinesterase and butyrylcholinesterase. Bioorg Med Chem. 2010 Jun 15;18(12):4475-84. DMHRV2A RU https://pubmed.ncbi.nlm.nih.gov/20471843 DM4JG9S DI DM4JG9S DM4JG9S DN 9-O-[3-(4-Bromo-phenoxyl)butyl]-berberine bromide DM4JG9S MI TT1RS9F DM4JG9S MN Acetylcholinesterase (AChE) DM4JG9S MT DTT DM4JG9S MA Inhibitor DM4JG9S RN Synthesis and biological evaluation of a new series of berberine derivatives as dual inhibitors of acetylcholinesterase and butyrylcholinesterase. Bioorg Med Chem. 2010 Jun 15;18(12):4475-84. DM4JG9S RU https://pubmed.ncbi.nlm.nih.gov/20471843 DM4JG9S DI DM4JG9S DM4JG9S DN 9-O-[3-(4-Bromo-phenoxyl)butyl]-berberine bromide DM4JG9S MI TTEB0GD DM4JG9S MN Cholinesterase (BCHE) DM4JG9S MT DTT DM4JG9S MA Inhibitor DM4JG9S RN Synthesis and biological evaluation of a new series of berberine derivatives as dual inhibitors of acetylcholinesterase and butyrylcholinesterase. Bioorg Med Chem. 2010 Jun 15;18(12):4475-84. DM4JG9S RU https://pubmed.ncbi.nlm.nih.gov/20471843 DMWVSPH DI DMWVSPH DMWVSPH DN 9-O-[3-(4-Nitro-phenoxyl)butyl]-berberine bromide DMWVSPH MI TT1RS9F DMWVSPH MN Acetylcholinesterase (AChE) DMWVSPH MT DTT DMWVSPH MA Inhibitor DMWVSPH RN Synthesis and biological evaluation of a new series of berberine derivatives as dual inhibitors of acetylcholinesterase and butyrylcholinesterase. Bioorg Med Chem. 2010 Jun 15;18(12):4475-84. DMWVSPH RU https://pubmed.ncbi.nlm.nih.gov/20471843 DMWVSPH DI DMWVSPH DMWVSPH DN 9-O-[3-(4-Nitro-phenoxyl)butyl]-berberine bromide DMWVSPH MI TTEB0GD DMWVSPH MN Cholinesterase (BCHE) DMWVSPH MT DTT DMWVSPH MA Inhibitor DMWVSPH RN Synthesis and biological evaluation of a new series of berberine derivatives as dual inhibitors of acetylcholinesterase and butyrylcholinesterase. Bioorg Med Chem. 2010 Jun 15;18(12):4475-84. DMWVSPH RU https://pubmed.ncbi.nlm.nih.gov/20471843 DMKPUWX DI DMKPUWX DMKPUWX DN 9-O-[3-(Phenylamino)propyl]-berberine bromide DMKPUWX MI TT1RS9F DMKPUWX MN Acetylcholinesterase (AChE) DMKPUWX MT DTT DMKPUWX MA Inhibitor DMKPUWX RN Synthesis and biological evaluation of a new series of berberine derivatives as dual inhibitors of acetylcholinesterase and butyrylcholinesterase. Bioorg Med Chem. 2010 Jun 15;18(12):4475-84. DMKPUWX RU https://pubmed.ncbi.nlm.nih.gov/20471843 DMKPUWX DI DMKPUWX DMKPUWX DN 9-O-[3-(Phenylamino)propyl]-berberine bromide DMKPUWX MI TTEB0GD DMKPUWX MN Cholinesterase (BCHE) DMKPUWX MT DTT DMKPUWX MA Inhibitor DMKPUWX RN Synthesis and biological evaluation of a new series of berberine derivatives as dual inhibitors of acetylcholinesterase and butyrylcholinesterase. Bioorg Med Chem. 2010 Jun 15;18(12):4475-84. DMKPUWX RU https://pubmed.ncbi.nlm.nih.gov/20471843 DM0FNUX DI DM0FNUX DM0FNUX DN 9-O-[3-(Phenylol-1-yloxy)propyl]berberine bromide DM0FNUX MI TT1RS9F DM0FNUX MN Acetylcholinesterase (AChE) DM0FNUX MT DTT DM0FNUX MA Inhibitor DM0FNUX RN Synthesis, biological evaluation, and molecular modeling of berberine derivatives as potent acetylcholinesterase inhibitors. Bioorg Med Chem. 2010 Feb;18(3):1244-51. DM0FNUX RU https://pubmed.ncbi.nlm.nih.gov/20056426 DM0FNUX DI DM0FNUX DM0FNUX DN 9-O-[3-(Phenylol-1-yloxy)propyl]berberine bromide DM0FNUX MI TTEB0GD DM0FNUX MN Cholinesterase (BCHE) DM0FNUX MT DTT DM0FNUX MA Inhibitor DM0FNUX RN Synthesis, biological evaluation, and molecular modeling of berberine derivatives as potent acetylcholinesterase inhibitors. Bioorg Med Chem. 2010 Feb;18(3):1244-51. DM0FNUX RU https://pubmed.ncbi.nlm.nih.gov/20056426 DM58XF6 DI DM58XF6 DM58XF6 DN 9-O-[4-(Phenylol-1-yloxy)butyl]berberine bromide DM58XF6 MI TT1RS9F DM58XF6 MN Acetylcholinesterase (AChE) DM58XF6 MT DTT DM58XF6 MA Inhibitor DM58XF6 RN Synthesis, biological evaluation, and molecular modeling of berberine derivatives as potent acetylcholinesterase inhibitors. Bioorg Med Chem. 2010 Feb;18(3):1244-51. DM58XF6 RU https://pubmed.ncbi.nlm.nih.gov/20056426 DM58XF6 DI DM58XF6 DM58XF6 DN 9-O-[4-(Phenylol-1-yloxy)butyl]berberine bromide DM58XF6 MI TTEB0GD DM58XF6 MN Cholinesterase (BCHE) DM58XF6 MT DTT DM58XF6 MA Inhibitor DM58XF6 RN Synthesis, biological evaluation, and molecular modeling of berberine derivatives as potent acetylcholinesterase inhibitors. Bioorg Med Chem. 2010 Feb;18(3):1244-51. DM58XF6 RU https://pubmed.ncbi.nlm.nih.gov/20056426 DMPZTG9 DI DMPZTG9 DMPZTG9 DN 9-O-[5-(Phenylol-1-yloxy)pentyl]berberine bromide DMPZTG9 MI TT1RS9F DMPZTG9 MN Acetylcholinesterase (AChE) DMPZTG9 MT DTT DMPZTG9 MA Inhibitor DMPZTG9 RN Synthesis, biological evaluation, and molecular modeling of berberine derivatives as potent acetylcholinesterase inhibitors. Bioorg Med Chem. 2010 Feb;18(3):1244-51. DMPZTG9 RU https://pubmed.ncbi.nlm.nih.gov/20056426 DMPZTG9 DI DMPZTG9 DMPZTG9 DN 9-O-[5-(Phenylol-1-yloxy)pentyl]berberine bromide DMPZTG9 MI TTEB0GD DMPZTG9 MN Cholinesterase (BCHE) DMPZTG9 MT DTT DMPZTG9 MA Inhibitor DMPZTG9 RN Synthesis, biological evaluation, and molecular modeling of berberine derivatives as potent acetylcholinesterase inhibitors. Bioorg Med Chem. 2010 Feb;18(3):1244-51. DMPZTG9 RU https://pubmed.ncbi.nlm.nih.gov/20056426 DM1DYU4 DI DM1DYU4 DM1DYU4 DN 9-octadecynoic acid DM1DYU4 MI TTPADOQ DM1DYU4 MN HMG-CoA reductase (HMGCR) DM1DYU4 MT DTT DM1DYU4 MA Inhibitor DM1DYU4 RN Novel Acetylenic Acids from the Root Bark of Paramacrolobium caeruleum: Inhibitors of 3-Hydroxy-3-methyl-glutaryl Coenzyme A Reductase J. Nat. Prod. 52(1):153-161 (1989). DM1DYU4 RU http://pubs.acs.org/doi/abs/10.1021/np50061a020 DMGORXQ DI DMGORXQ DMGORXQ DN 9-OH-risperidone DMGORXQ MI TTSQIFT DMGORXQ MN 5-HT 1A receptor (HTR1A) DMGORXQ MT DTT DMGORXQ MA Antagonist DMGORXQ RN Risperidone compared with new and reference antipsychotic drugs: in vitro and in vivo receptor binding. Psychopharmacology (Berl). 1996 Mar;124(1-2):57-73. DMGORXQ RU https://pubmed.ncbi.nlm.nih.gov/8935801 DMGORXQ DI DMGORXQ DMGORXQ DN 9-OH-risperidone DMGORXQ MI TTK8CXU DMGORXQ MN 5-HT 1B receptor (HTR1B) DMGORXQ MT DTT DMGORXQ MA Antagonist DMGORXQ RN Risperidone compared with new and reference antipsychotic drugs: in vitro and in vivo receptor binding. Psychopharmacology (Berl). 1996 Mar;124(1-2):57-73. DMGORXQ RU https://pubmed.ncbi.nlm.nih.gov/8935801 DMGORXQ DI DMGORXQ DMGORXQ DN 9-OH-risperidone DMGORXQ MI TT6MSOK DMGORXQ MN 5-HT 1D receptor (HTR1D) DMGORXQ MT DTT DMGORXQ MA Antagonist DMGORXQ RN Risperidone compared with new and reference antipsychotic drugs: in vitro and in vivo receptor binding. Psychopharmacology (Berl). 1996 Mar;124(1-2):57-73. DMGORXQ RU https://pubmed.ncbi.nlm.nih.gov/8935801 DMGORXQ DI DMGORXQ DMGORXQ DN 9-OH-risperidone DMGORXQ MI TTCPG9S DMGORXQ MN 5-HT 1E receptor (HTR1E) DMGORXQ MT DTT DMGORXQ MA Antagonist DMGORXQ RN Risperidone compared with new and reference antipsychotic drugs: in vitro and in vivo receptor binding. Psychopharmacology (Berl). 1996 Mar;124(1-2):57-73. DMGORXQ RU https://pubmed.ncbi.nlm.nih.gov/8935801 DMGORXQ DI DMGORXQ DMGORXQ DN 9-OH-risperidone DMGORXQ MI TTJQOD7 DMGORXQ MN 5-HT 2A receptor (HTR2A) DMGORXQ MT DTT DMGORXQ MA Antagonist DMGORXQ RN Risperidone compared with new and reference antipsychotic drugs: in vitro and in vivo receptor binding. Psychopharmacology (Berl). 1996 Mar;124(1-2):57-73. DMGORXQ RU https://pubmed.ncbi.nlm.nih.gov/8935801 DMGORXQ DI DMGORXQ DMGORXQ DN 9-OH-risperidone DMGORXQ MI TTTIBOJ DMGORXQ MN Histamine H1 receptor (H1R) DMGORXQ MT DTT DMGORXQ MA Antagonist DMGORXQ RN Risperidone compared with new and reference antipsychotic drugs: in vitro and in vivo receptor binding. Psychopharmacology (Berl). 1996 Mar;124(1-2):57-73. DMGORXQ RU https://pubmed.ncbi.nlm.nih.gov/8935801 DMJFBQ1 DI DMJFBQ1 DMJFBQ1 DN 9-phenanthrol DMJFBQ1 MI TTJ2HKA DMJFBQ1 MN Long transient receptor potential channel 4 (TRPM4) DMJFBQ1 MT DTT DMJFBQ1 MA Blocker (channel blocker) DMJFBQ1 RN 9-phenanthrol inhibits human TRPM4 but not TRPM5 cationic channels. Br J Pharmacol. 2008 Apr;153(8):1697-705. DMJFBQ1 RU https://pubmed.ncbi.nlm.nih.gov/18297105 DMRCM7Q DI DMRCM7Q DMRCM7Q DN 9-Phenyl-2,3-dihydro-1H-indeno[2,1-c]pyridine DMRCM7Q MI TTTIBOJ DMRCM7Q MN Histamine H1 receptor (H1R) DMRCM7Q MT DTT DMRCM7Q MA Inhibitor DMRCM7Q RN Conformationally-restricted ligands for the histamine H1 receptor. Bioorg Med Chem Lett. 2000 Jun 5;10(11):1277-9. DMRCM7Q RU https://pubmed.ncbi.nlm.nih.gov/10866399 DM73O2A DI DM73O2A DM73O2A DN 9-Phenyl-9H-purin-6-ylamine DM73O2A MI TTK25J1 DM73O2A MN Adenosine A1 receptor (ADORA1) DM73O2A MT DTT DM73O2A MA Inhibitor DM73O2A RN N6,9-disubstituted adenines: potent, selective antagonists at the A1 adenosine receptor. J Med Chem. 1991 Sep;34(9):2877-82. DM73O2A RU https://pubmed.ncbi.nlm.nih.gov/1895305 DMO17J0 DI DMO17J0 DMO17J0 DN 9-Phenylethyl-9H-adenine DMO17J0 MI TTM2AOE DMO17J0 MN Adenosine A2a receptor (ADORA2A) DMO17J0 MT DTT DMO17J0 MA Inhibitor DMO17J0 RN 8-Bromo-9-alkyl adenine derivatives as tools for developing new adenosine A2A and A2B receptors ligands. Bioorg Med Chem. 2009 Apr 1;17(7):2812-22. DMO17J0 RU https://pubmed.ncbi.nlm.nih.gov/19282184 DMQTEPY DI DMQTEPY DMQTEPY DN 9-Propyl-9H-adenine DMQTEPY MI TTK25J1 DMQTEPY MN Adenosine A1 receptor (ADORA1) DMQTEPY MT DTT DMQTEPY MA Inhibitor DMQTEPY RN 8-Bromo-9-alkyl adenine derivatives as tools for developing new adenosine A2A and A2B receptors ligands. Bioorg Med Chem. 2009 Apr 1;17(7):2812-22. DMQTEPY RU https://pubmed.ncbi.nlm.nih.gov/19282184 DMQTEPY DI DMQTEPY DMQTEPY DN 9-Propyl-9H-adenine DMQTEPY MI TTM2AOE DMQTEPY MN Adenosine A2a receptor (ADORA2A) DMQTEPY MT DTT DMQTEPY MA Inhibitor DMQTEPY RN 8-Bromo-9-alkyl adenine derivatives as tools for developing new adenosine A2A and A2B receptors ligands. Bioorg Med Chem. 2009 Apr 1;17(7):2812-22. DMQTEPY RU https://pubmed.ncbi.nlm.nih.gov/19282184 DMQTEPY DI DMQTEPY DMQTEPY DN 9-Propyl-9H-adenine DMQTEPY MI TTNE7KG DMQTEPY MN Adenosine A2b receptor (ADORA2B) DMQTEPY MT DTT DMQTEPY MA Inhibitor DMQTEPY RN 8-Bromo-9-alkyl adenine derivatives as tools for developing new adenosine A2A and A2B receptors ligands. Bioorg Med Chem. 2009 Apr 1;17(7):2812-22. DMQTEPY RU https://pubmed.ncbi.nlm.nih.gov/19282184 DM1H3FJ DI DM1H3FJ DM1H3FJ DN A 137491 DM1H3FJ MI TTQL5VC DM1H3FJ MN Platelet-activating factor receptor (PTAFR) DM1H3FJ MT DTT DM1H3FJ MA Modulator DM1H3FJ RN The role of platelet-activating factor (PAF) and the efficacy of ABT-491, a highly potent and selective PAF antagonist, in experimental allergic rhinitis. J Pharmacol Exp Ther. 1998 Jan;284(1):83-8. DM1H3FJ RU https://pubmed.ncbi.nlm.nih.gov/9435164 DMHSPRE DI DMHSPRE DMHSPRE DN A-058 DMHSPRE MI TTMVBWH DMHSPRE MN Hepatitis C virus RNA-directed RNA polymerase (HCV NS5B) DMHSPRE MT DTT DMHSPRE MA Modulator DMHSPRE RN The ChEMBL database in 2017. Nucleic Acids Res. 2017 Jan 4;45(D1):D945-D954. DMHSPRE RU https://www.ncbi.nlm.nih.gov/pubmed/27899562 DM1DWRN DI DM1DWRN DM1DWRN DN A-119637 DM1DWRN MI TTNGILX DM1DWRN MN Adrenergic receptor alpha-1A (ADRA1A) DM1DWRN MT DTT DM1DWRN MA Inhibitor DM1DWRN RN Pharmacophore identification of alpha(1A)-adrenoceptor antagonists. Bioorg Med Chem Lett. 2005 Feb 1;15(3):657-64. DM1DWRN RU https://pubmed.ncbi.nlm.nih.gov/15664832 DM1DWRN DI DM1DWRN DM1DWRN DN A-119637 DM1DWRN MI TTBRKXS DM1DWRN MN Adrenergic receptor alpha-1B (ADRA1B) DM1DWRN MT DTT DM1DWRN MA Inhibitor DM1DWRN RN Two novel and potent 3-[(o-methoxyphenyl)piperazinylethyl]-5-phenylthien. Bioorg Med Chem Lett. 2001 May 7;11(9):1119-21. DM1DWRN RU https://pubmed.ncbi.nlm.nih.gov/11354357 DMZ51UJ DI DMZ51UJ DMZ51UJ DN A-123189 DMZ51UJ MI TTNGILX DMZ51UJ MN Adrenergic receptor alpha-1A (ADRA1A) DMZ51UJ MT DTT DMZ51UJ MA Inhibitor DMZ51UJ RN Pharmacophore identification of alpha(1A)-adrenoceptor antagonists. Bioorg Med Chem Lett. 2005 Feb 1;15(3):657-64. DMZ51UJ RU https://pubmed.ncbi.nlm.nih.gov/15664832 DMZ51UJ DI DMZ51UJ DMZ51UJ DN A-123189 DMZ51UJ MI TTBRKXS DMZ51UJ MN Adrenergic receptor alpha-1B (ADRA1B) DMZ51UJ MT DTT DMZ51UJ MA Inhibitor DMZ51UJ RN Two novel and potent 3-[(o-methoxyphenyl)piperazinylethyl]-5-phenylthien. Bioorg Med Chem Lett. 2001 May 7;11(9):1119-21. DMZ51UJ RU https://pubmed.ncbi.nlm.nih.gov/11354357 DMV03NS DI DMV03NS DMV03NS DN A-192558 DMV03NS MI TT50QJ3 DMV03NS MN Influenza Neuraminidase (Influ NA) DMV03NS MT DTT DMV03NS MA Inhibitor DMV03NS RN Antiviral agents active against influenza A viruses. Nat Rev Drug Discov. 2006 Dec;5(12):1015-25. DMV03NS RU https://pubmed.ncbi.nlm.nih.gov/17139286 DMV8AH6 DI DMV8AH6 DMV8AH6 DN A192621 DMV8AH6 MI TT3ZTGU DMV8AH6 MN Endothelin B receptor (EDNRB) DMV8AH6 MT DTT DMV8AH6 MA Antagonist DMV8AH6 RN Pyrrolidine-3-carboxylic acids as endothelin antagonists. 4. Side chain conformational restriction leads to ET(B) selectivity. J Med Chem. 1999 Sep 9;42(18):3668-78. DMV8AH6 RU https://pubmed.ncbi.nlm.nih.gov/10479298 DM5VQ8E DI DM5VQ8E DM5VQ8E DN A-224940 DM5VQ8E MI TTX4RTB DM5VQ8E MN Melanin-concentrating hormone receptor 1 (MCHR1) DM5VQ8E MT DTT DM5VQ8E MA Inhibitor DM5VQ8E RN Synthesis and evaluation of 2-amino-8-alkoxy quinolines as MCHr1 antagonists. Part 3. Bioorg Med Chem Lett. 2004 Oct 4;14(19):4883-6. DM5VQ8E RU https://pubmed.ncbi.nlm.nih.gov/15341944 DM98VFW DI DM98VFW DM98VFW DN A-286982 DM98VFW MI TTA1L39 DM98VFW MN ICAM1 messenger RNA (ICAM1 mRNA) DM98VFW MT DTT DM98VFW MA Inhibitor DM98VFW RN Discovery of tetrahydroisoquinoline (THIQ) derivatives as potent and orally bioavailable LFA-1/ICAM-1 antagonists. Bioorg Med Chem Lett. 2010 Sep 1;20(17):5269-73. DM98VFW RU https://pubmed.ncbi.nlm.nih.gov/20655213 DM98VFW DI DM98VFW DM98VFW DN A-286982 DM98VFW MI TT48WR6 DM98VFW MN Integrin alpha-L (ITGAL) DM98VFW MT DTT DM98VFW MA Inhibitor DM98VFW RN Discovery of tetrahydroisoquinoline (THIQ) derivatives as potent and orally bioavailable LFA-1/ICAM-1 antagonists. Bioorg Med Chem Lett. 2010 Sep 1;20(17):5269-73. DM98VFW RU https://pubmed.ncbi.nlm.nih.gov/20655213 DM98VFW DI DM98VFW DM98VFW DN A-286982 DM98VFW MI TTIJWR7 DM98VFW MN Integrin beta-2 (ITGB2) DM98VFW MT DTT DM98VFW MA Inhibitor DM98VFW RN Novel p-arylthio cinnamides as antagonists of leukocyte function-associated antigen-1/intracellular adhesion molecule-1 interaction. 2. Mechanism o... J Med Chem. 2001 Apr 12;44(8):1202-10. DM98VFW RU https://pubmed.ncbi.nlm.nih.gov/11312920 DMK4OD7 DI DMK4OD7 DMK4OD7 DN A2P5P DMK4OD7 MI TTA93TL DMK4OD7 MN P2Y purinoceptor 1 (P2RY1) DMK4OD7 MT DTT DMK4OD7 MA Antagonist DMK4OD7 RN Identification of competitive antagonists of the P2Y1 receptor. Mol Pharmacol. 1996 Nov;50(5):1323-9. DMK4OD7 RU https://pubmed.ncbi.nlm.nih.gov/8913364 DMPI0YX DI DMPI0YX DMPI0YX DN A-304121 DMPI0YX MI TT9JNIC DMPI0YX MN Histamine H3 receptor (H3R) DMPI0YX MT DTT DMPI0YX MA Antagonist DMPI0YX RN Pharmacological and behavioral properties of A-349821, a selective and potent human histamine H3 receptor antagonist. Biochem Pharmacol. 2004 Sep 1;68(5):933-45. DMPI0YX RU https://pubmed.ncbi.nlm.nih.gov/15294456 DML4P6O DI DML4P6O DML4P6O DN A-313326 DML4P6O MI TT7WZIJ DML4P6O MN CAAX farnesyltransferase beta (FNTB) DML4P6O MT DTT DML4P6O MA Inhibitor DML4P6O RN Design and synthesis of o-trifluoromethylbiphenyl substituted 2-amino-nicotinonitriles as inhibitors of farnesyltransferase. Bioorg Med Chem Lett. 2005 Jan 3;15(1):153-8. DML4P6O RU https://pubmed.ncbi.nlm.nih.gov/15582430 DML4P6O DI DML4P6O DML4P6O DN A-313326 DML4P6O MI TTX20QP DML4P6O MN Geranylgeranyl transferase I (GGTase-I) DML4P6O MT DTT DML4P6O MA Inhibitor DML4P6O RN Design and synthesis of o-trifluoromethylbiphenyl substituted 2-amino-nicotinonitriles as inhibitors of farnesyltransferase. Bioorg Med Chem Lett. 2005 Jan 3;15(1):153-8. DML4P6O RU https://pubmed.ncbi.nlm.nih.gov/15582430 DMV8MKP DI DMV8MKP DMV8MKP DN A-315456 DMV8MKP MI TTNGILX DMV8MKP MN Adrenergic receptor alpha-1A (ADRA1A) DMV8MKP MT DTT DMV8MKP MA Inhibitor DMV8MKP RN Pharmacophore identification of alpha(1A)-adrenoceptor antagonists. Bioorg Med Chem Lett. 2005 Feb 1;15(3):657-64. DMV8MKP RU https://pubmed.ncbi.nlm.nih.gov/15664832 DMSQLZF DI DMSQLZF DMSQLZF DN A-315675 DMSQLZF MI TT50QJ3 DMSQLZF MN Influenza Neuraminidase (Influ NA) DMSQLZF MT DTT DMSQLZF MA Inhibitor DMSQLZF RN Antiviral agents active against influenza A viruses. Nat Rev Drug Discov. 2006 Dec;5(12):1015-25. DMSQLZF RU https://pubmed.ncbi.nlm.nih.gov/17139286 DMGWO9J DI DMGWO9J DMGWO9J DN A-317567 DMGWO9J MI TTVMWLP DMGWO9J MN Acid-sensing ion channel 2 (ASIC2) DMGWO9J MT DTT DMGWO9J MA Blocker (channel blocker) DMGWO9J RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 685). DMGWO9J RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=685 DMGWO9J DI DMGWO9J DMGWO9J DN A-317567 DMGWO9J MI TTLGDIS DMGWO9J MN Acid-sensing ion channel 3 (ASIC3) DMGWO9J MT DTT DMGWO9J MA Blocker (channel blocker) DMGWO9J RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 686). DMGWO9J RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=686 DM124K5 DI DM124K5 DM124K5 DN A-317920 DM124K5 MI TT9JNIC DM124K5 MN Histamine H3 receptor (H3R) DM124K5 MT DTT DM124K5 MA Antagonist DM124K5 RN The histamine H3 receptor: from gene cloning to H3 receptor drugs. Nat Rev Drug Discov. 2005 Feb;4(2):107-20. DM124K5 RU https://pubmed.ncbi.nlm.nih.gov/15665857 DMPU3QR DI DMPU3QR DMPU3QR DN A-331440 DMPU3QR MI TT9JNIC DMPU3QR MN Histamine H3 receptor (H3R) DMPU3QR MT DTT DMPU3QR MA Antagonist DMPU3QR RN The histamine H3 receptor: from gene cloning to H3 receptor drugs. Nat Rev Drug Discov. 2005 Feb;4(2):107-20. DMPU3QR RU https://pubmed.ncbi.nlm.nih.gov/15665857 DMFNR3Y DI DMFNR3Y DMFNR3Y DN A35566-A DMFNR3Y MI TTGTQHC DMFNR3Y MN DNA topoisomerase I (TOP1) DMFNR3Y MT DTT DMFNR3Y MA Inhibitor DMFNR3Y RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2636). DMFNR3Y RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2636 DMZHDWN DI DMZHDWN DMZHDWN DN A-357300 DMZHDWN MI TTZL0OI DMZHDWN MN Methionine aminopeptidase 2 (METAP2) DMZHDWN MT DTT DMZHDWN MA Inhibitor DMZHDWN RN Tumor suppression by a rationally designed reversible inhibitor of methionine aminopeptidase-2. Cancer Res. 2003 Nov 15;63(22):7861-9. DMZHDWN RU https://pubmed.ncbi.nlm.nih.gov/14633714 DMI4TVB DI DMI4TVB DMI4TVB DN A-381393 DMI4TVB MI TTE0A2F DMI4TVB MN Dopamine D4 receptor (D4R) DMI4TVB MT DTT DMI4TVB MA Antagonist DMI4TVB RN Dopamine D4 receptor involvement in the discriminative stimulus effects in rats of LSD, but not the phenethylamine hallucinogen DOI. Psychopharmacology (Berl). 2009 Apr;203(2):265-77. DMI4TVB RU https://pubmed.ncbi.nlm.nih.gov/18604600 DMSTZ14 DI DMSTZ14 DMSTZ14 DN A-395 DMSTZ14 MI TTFNJ4R DMSTZ14 MN Embryonic ectoderm development protein (EED) DMSTZ14 MT DTT DMSTZ14 MA Inhibitor DMSTZ14 RN The EED protein-protein interaction inhibitor A-395 inactivates the PRC2 complex. Nat Chem Biol. 2017 Apr;13(4):389-395. DMSTZ14 RU https://pubmed.ncbi.nlm.nih.gov/28135237 DMKY9G5 DI DMKY9G5 DMKY9G5 DN A412997 DMKY9G5 MI TTE0A2F DMKY9G5 MN Dopamine D4 receptor (D4R) DMKY9G5 MT DTT DMKY9G5 MA Agonist DMKY9G5 RN A-412997 is a selective dopamine D4 receptor agonist in rats. Pharmacol Biochem Behav. 2005 Sep;82(1):140-7. DMKY9G5 RU https://pubmed.ncbi.nlm.nih.gov/16153699 DM7HSCI DI DM7HSCI DM7HSCI DN A-420983 DM7HSCI MI TT9VGXW DM7HSCI MN Angiopoietin 1 receptor (TEK) DM7HSCI MT DTT DM7HSCI MA Inhibitor DM7HSCI RN A-420983: a potent, orally active inhibitor of lck with efficacy in a model of transplant rejection. Bioorg Med Chem Lett. 2004 May 17;14(10):2613-6. DM7HSCI RU https://pubmed.ncbi.nlm.nih.gov/15109663 DM7HSCI DI DM7HSCI DM7HSCI DN A-420983 DM7HSCI MI TT860QF DM7HSCI MN LCK tyrosine protein kinase (LCK) DM7HSCI MT DTT DM7HSCI MA Inhibitor DM7HSCI RN A-420983: a potent, orally active inhibitor of lck with efficacy in a model of transplant rejection. Bioorg Med Chem Lett. 2004 May 17;14(10):2613-6. DM7HSCI RU https://pubmed.ncbi.nlm.nih.gov/15109663 DM7HSCI DI DM7HSCI DM7HSCI DN A-420983 DM7HSCI MI TT6PKBN DM7HSCI MN Proto-oncogene c-Src (SRC) DM7HSCI MT DTT DM7HSCI MA Inhibitor DM7HSCI RN A-420983: a potent, orally active inhibitor of lck with efficacy in a model of transplant rejection. Bioorg Med Chem Lett. 2004 May 17;14(10):2613-6. DM7HSCI RU https://pubmed.ncbi.nlm.nih.gov/15109663 DMM5XD6 DI DMM5XD6 DMM5XD6 DN A-425444 DMM5XD6 MI TTE0A2F DMM5XD6 MN Dopamine D4 receptor (D4R) DMM5XD6 MT DTT DMM5XD6 MA Inhibitor DMM5XD6 RN Discovery of 3-methyl-N-(1-oxy-3',4',5',6'-tetrahydro-2'H-[2,4'-bipyridine]-1'-ylmethyl)benzamide (ABT-670), an orally bioavailable dopamine D4 ago... J Med Chem. 2006 Dec 14;49(25):7450-65. DMM5XD6 RU https://pubmed.ncbi.nlm.nih.gov/17149874 DMQHKIA DI DMQHKIA DMQHKIA DN A-432411 DMQHKIA MI TTTU902 DMQHKIA MN Checkpoint kinase-1 (CHK1) DMQHKIA MT DTT DMQHKIA MA Inhibitor DMQHKIA RN Synthesis of selenophene derivatives as novel CHK1 inhibitors. Bioorg Med Chem Lett. 2010 Sep 1;20(17):5065-8. DMQHKIA RU https://pubmed.ncbi.nlm.nih.gov/20674356 DMUBM8X DI DMUBM8X DMUBM8X DN A438079 DMUBM8X MI TT473XN DMUBM8X MN P2X purinoceptor 7 (P2RX7) DMUBM8X MT DTT DMUBM8X MA Antagonist DMUBM8X RN Discovery of P2X7 receptor-selective antagonists offers new insights into P2X7 receptor function and indicates a role in chronic pain states. Br J Pharmacol. 2007 Jul;151(5):571-9. DMUBM8X RU https://pubmed.ncbi.nlm.nih.gov/17471177 DMLMU63 DI DMLMU63 DMLMU63 DN A-443654 DMLMU63 MI TTWTSCV DMLMU63 MN RAC-alpha serine/threonine-protein kinase (AKT1) DMLMU63 MT DTT DMLMU63 MA Inhibitor DMLMU63 RN Syntheses of potent, selective, and orally bioavailable indazole-pyridine series of protein kinase B/Akt inhibitors with reduced hypotension. J Med Chem. 2007 Jun 28;50(13):2990-3003. DMLMU63 RU https://pubmed.ncbi.nlm.nih.gov/17523610 DMN320E DI DMN320E DMN320E DN A-558693 DMN320E MI TTG5QB7 DMN320E MN Calpain-2 (CAPN2) DMN320E MT DTT DMN320E MA Inhibitor DMN320E RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2336). DMN320E RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2336 DM7R8DJ DI DM7R8DJ DM7R8DJ DN A-582941 DM7R8DJ MI TTLA931 DM7R8DJ MN Neuronal acetylcholine receptor alpha-7 (CHRNA7) DM7R8DJ MT DTT DM7R8DJ MA Agonist DM7R8DJ RN Broad-spectrum efficacy across cognitive domains by alpha7 nicotinic acetylcholine receptor agonism correlates with activation of ERK1/2 and CREB phosphorylation pathways. J Neurosci. 2007 Sep 26;27(39):10578-87. DM7R8DJ RU https://pubmed.ncbi.nlm.nih.gov/17898229 DM7W2ME DI DM7W2ME DM7W2ME DN A61603 DM7W2ME MI TT2NUT5 DM7W2ME MN Adrenergic receptor alpha-2C (ADRA2C) DM7W2ME MT DTT DM7W2ME MA Agonist DM7W2ME RN A-61603, a potent alpha 1-adrenergic receptor agonist, selective for the alpha 1A receptor subtype. J Pharmacol Exp Ther. 1995 Jul;274(1):97-103. DM7W2ME RU https://pubmed.ncbi.nlm.nih.gov/7616455 DM9SXDI DI DM9SXDI DM9SXDI DN A-620223 DM9SXDI MI TTVDSZ0 DM9SXDI MN Poly [ADP-ribose] polymerase 1 (PARP1) DM9SXDI MT DTT DM9SXDI MA Inhibitor DM9SXDI RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2771). DM9SXDI RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2771 DMJ6IMZ DI DMJ6IMZ DMJ6IMZ DN A-62824 DMJ6IMZ MI TTFK8YB DMJ6IMZ MN Bacterial DNA topoisomerase 4A (Bact parC) DMJ6IMZ MT DTT DMJ6IMZ MA Inhibitor DMJ6IMZ RN Isothiazoloquinolones containing functionalized aromatic hydrocarbons at the 7-position: synthesis and in vitro activity of a series of potent anti... Bioorg Med Chem Lett. 2006 Mar 1;16(5):1272-6. DMJ6IMZ RU https://pubmed.ncbi.nlm.nih.gov/16337791 DM5JSXI DI DM5JSXI DM5JSXI DN A-641359 DM5JSXI MI TT860QF DM5JSXI MN LCK tyrosine protein kinase (LCK) DM5JSXI MT DTT DM5JSXI MA Inhibitor DM5JSXI RN Discovery of A-770041, a src-family selective orally active lck inhibitor that prevents organ allograft rejection. Bioorg Med Chem Lett. 2006 Jan 1;16(1):118-22. DM5JSXI RU https://pubmed.ncbi.nlm.nih.gov/16216497 DMJ83LK DI DMJ83LK DMJ83LK DN A-674563 DMJ83LK MI TTWTSCV DMJ83LK MN RAC-alpha serine/threonine-protein kinase (AKT1) DMJ83LK MT DTT DMJ83LK MA Inhibitor DMJ83LK RN Comprehensive analysis of kinase inhibitor selectivity. Nat Biotechnol. 2011 Oct 30;29(11):1046-51. DMJ83LK RU https://pubmed.ncbi.nlm.nih.gov/22037378 DMT6A7G DI DMT6A7G DMT6A7G DN A-690344 DMT6A7G MI TTEX248 DMT6A7G MN Dopamine D2 receptor (D2R) DMT6A7G MT DTT DMT6A7G MA Inhibitor DMT6A7G RN Synthesis and SAR of highly potent and selective dopamine D(3)-receptor antagonists: 1H-pyrimidin-2-one derivatives. Bioorg Med Chem Lett. 2006 Feb;16(3):490-4. DMT6A7G RU https://pubmed.ncbi.nlm.nih.gov/16290141 DMT6A7G DI DMT6A7G DMT6A7G DN A-690344 DMT6A7G MI TT4C8EA DMT6A7G MN Dopamine D3 receptor (D3R) DMT6A7G MT DTT DMT6A7G MA Inhibitor DMT6A7G RN Synthesis and SAR of highly potent and selective dopamine D(3)-receptor antagonists: 1H-pyrimidin-2-one derivatives. Bioorg Med Chem Lett. 2006 Feb;16(3):490-4. DMT6A7G RU https://pubmed.ncbi.nlm.nih.gov/16290141 DMXOPFU DI DMXOPFU DMXOPFU DN A-706149 DMXOPFU MI TTEX248 DMXOPFU MN Dopamine D2 receptor (D2R) DMXOPFU MT DTT DMXOPFU MA Inhibitor DMXOPFU RN Synthesis and SAR of highly potent and selective dopamine D(3)-receptor antagonists: Quinolin(di)one and benzazepin(di)one derivatives. herve.genes... Bioorg Med Chem Lett. 2006 Feb;16(3):658-62. DMXOPFU RU https://pubmed.ncbi.nlm.nih.gov/16271293 DMXOPFU DI DMXOPFU DMXOPFU DN A-706149 DMXOPFU MI TT4C8EA DMXOPFU MN Dopamine D3 receptor (D3R) DMXOPFU MT DTT DMXOPFU MA Inhibitor DMXOPFU RN Synthesis and SAR of highly potent and selective dopamine D(3)-receptor antagonists: Quinolin(di)one and benzazepin(di)one derivatives. herve.genes... Bioorg Med Chem Lett. 2006 Feb;16(3):658-62. DMXOPFU RU https://pubmed.ncbi.nlm.nih.gov/16271293 DMI7J1L DI DMI7J1L DMI7J1L DN A-740003 DMI7J1L MI TT473XN DMI7J1L MN P2X purinoceptor 7 (P2RX7) DMI7J1L MT DTT DMI7J1L MA Inhibitor DMI7J1L RN Purinergic P2X(7) receptor antagonists: Chemistry and fundamentals of biological screening. Bioorg Med Chem. 2009 Jul 15;17(14):4861-5. DMI7J1L RU https://pubmed.ncbi.nlm.nih.gov/19540765 DMT9N1I DI DMT9N1I DMT9N1I DN A-76341 DMT9N1I MI TT3C1VN DMT9N1I MN Enzyme unspecific (Enz) DMT9N1I MT DTT DMT9N1I MA Modulator DMT9N1I RN WO patent application no. 2013,1850,32, Nanotherapeutics for drug targeting. DMT9N1I RU http://worldwide.espacenet.com/publicationDetails/biblio?DB=worldwide.espacenet.com&II=0&ND=3&adjacent=true&locale=en_EP&FT=D&date=20131212&CC=WO&NR=2013185032A1&KC=A1 DMP78JY DI DMP78JY DMP78JY DN A-770041 DMP78JY MI TT860QF DMP78JY MN LCK tyrosine protein kinase (LCK) DMP78JY MT DTT DMP78JY MA Inhibitor DMP78JY RN Discovery of A-770041, a src-family selective orally active lck inhibitor that prevents organ allograft rejection. Bioorg Med Chem Lett. 2006 Jan 1;16(1):118-22. DMP78JY RU https://pubmed.ncbi.nlm.nih.gov/16216497 DMP78JY DI DMP78JY DMP78JY DN A-770041 DMP78JY MI TT6PKBN DMP78JY MN Proto-oncogene c-Src (SRC) DMP78JY MT DTT DMP78JY MA Inhibitor DMP78JY RN Discovery of A-770041, a src-family selective orally active lck inhibitor that prevents organ allograft rejection. Bioorg Med Chem Lett. 2006 Jan 1;16(1):118-22. DMP78JY RU https://pubmed.ncbi.nlm.nih.gov/16216497 DMG6ZHO DI DMG6ZHO DMG6ZHO DN A778317 DMG6ZHO MI TTMI6F5 DMG6ZHO MN Transient receptor potential cation channel V1 (TRPV1) DMG6ZHO MT DTT DMG6ZHO MA Blocker (channel blocker) DMG6ZHO RN [3H]A-778317 [1-((R)-5-tert-butyl-indan-1-yl)-3-isoquinolin-5-yl-urea]: a novel, stereoselective, high-affinity antagonist is a useful radioligand ... J Pharmacol Exp Ther. 2007 Oct;323(1):285-93. DMG6ZHO RU https://pubmed.ncbi.nlm.nih.gov/17660385 DM6BRTF DI DM6BRTF DM6BRTF DN A-794278 DM6BRTF MI TTVBPDM DM6BRTF MN Metabotropic glutamate receptor 1 (mGluR1) DM6BRTF MT DTT DM6BRTF MA Modulator (allosteric modulator) DM6BRTF RN Structure-activity relationship of triazafluorenone derivatives as potent and selective mGluR1 antagonists. J Med Chem. 2005 Nov 17;48(23):7374-88. DM6BRTF RU https://pubmed.ncbi.nlm.nih.gov/16279797 DMU965M DI DMU965M DMU965M DN A-794282 DMU965M MI TTVBPDM DMU965M MN Metabotropic glutamate receptor 1 (mGluR1) DMU965M MT DTT DMU965M MA Modulator (allosteric modulator) DMU965M RN Structure-activity relationship of triazafluorenone derivatives as potent and selective mGluR1 antagonists. J Med Chem. 2005 Nov 17;48(23):7374-88. DMU965M RU https://pubmed.ncbi.nlm.nih.gov/16279797 DM2W4IQ DI DM2W4IQ DM2W4IQ DN A-795614 DM2W4IQ MI TTMI6F5 DM2W4IQ MN Transient receptor potential cation channel V1 (TRPV1) DM2W4IQ MT DTT DM2W4IQ MA Inhibitor DM2W4IQ RN Tetrahydropyridine-4-carboxamides as novel, potent transient receptor potential vanilloid 1 (TRPV1) antagonists. Bioorg Med Chem. 2008 Sep 15;16(18):8516-25. DM2W4IQ RU https://pubmed.ncbi.nlm.nih.gov/18722778 DMHFPRJ DI DMHFPRJ DMHFPRJ DN A-796260 DMHFPRJ MI TT6OEDT DMHFPRJ MN Cannabinoid receptor 1 (CB1) DMHFPRJ MT DTT DMHFPRJ MA Inhibitor DMHFPRJ RN Indol-3-ylcycloalkyl ketones: effects of N1 substituted indole side chain variations on CB(2) cannabinoid receptor activity. J Med Chem. 2010 Jan 14;53(1):295-315. DMHFPRJ RU https://pubmed.ncbi.nlm.nih.gov/19921781 DMHFPRJ DI DMHFPRJ DMHFPRJ DN A-796260 DMHFPRJ MI TTMSFAW DMHFPRJ MN Cannabinoid receptor 2 (CB2) DMHFPRJ MT DTT DMHFPRJ MA Inhibitor DMHFPRJ RN Indol-3-ylcycloalkyl ketones: effects of N1 substituted indole side chain variations on CB(2) cannabinoid receptor activity. J Med Chem. 2010 Jan 14;53(1):295-315. DMHFPRJ RU https://pubmed.ncbi.nlm.nih.gov/19921781 DML20N9 DI DML20N9 DML20N9 DN A-80040 DML20N9 MI TTY84UG DML20N9 MN Acetyl-CoA carboxylase 2 (ACACB) DML20N9 MT DTT DML20N9 MA Inhibitor DML20N9 RN Synthesis and structure-activity relationships of N-{3-[2-(4-alkoxyphenoxy)thiazol-5-yl]-1- methylprop-2-ynyl}carboxy derivatives as selective acet... J Med Chem. 2006 Jun 29;49(13):3770-3. DML20N9 RU https://pubmed.ncbi.nlm.nih.gov/16789734 DML20N9 DI DML20N9 DML20N9 DN A-80040 DML20N9 MI TTYAWV0 DML20N9 MN Plasmodium Acetyl-CoA carboxylase 1 (Malaria ACC1) DML20N9 MT DTT DML20N9 MA Inhibitor DML20N9 RN Synthesis and structure-activity relationships of N-{3-[2-(4-alkoxyphenoxy)thiazol-5-yl]-1- methylprop-2-ynyl}carboxy derivatives as selective acet... J Med Chem. 2006 Jun 29;49(13):3770-3. DML20N9 RU https://pubmed.ncbi.nlm.nih.gov/16789734 DMWGRL8 DI DMWGRL8 DMWGRL8 DN A-803467 DMWGRL8 MI TT90XZ8 DMWGRL8 MN Voltage-gated sodium channel alpha Nav1.8 (SCN10A) DMWGRL8 MT DTT DMWGRL8 MA Inhibitor DMWGRL8 RN Sensory neuron voltage-gated sodium channels as analgesic drug targets. Curr Opin Neurobiol. 2008 Aug;18(4):383-8. DMWGRL8 RU https://pubmed.ncbi.nlm.nih.gov/18824099 DMLC7HE DI DMLC7HE DMLC7HE DN A804598 DMLC7HE MI TT473XN DMLC7HE MN P2X purinoceptor 7 (P2RX7) DMLC7HE MT DTT DMLC7HE MA Antagonist DMLC7HE RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 484). DMLC7HE RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=484 DMQ5AJW DI DMQ5AJW DMQ5AJW DN A-82186 DMQ5AJW MI TTGN1ZA DMQ5AJW MN Angiotensin II receptor (AGTR) DMQ5AJW MT DTT DMQ5AJW MA Modulator DMQ5AJW RN WO patent application no. 2011,0583,31, Pemirolast for the treatment of systemic low grade inflammation. DMQ5AJW RU http://worldwide.espacenet.com/publicationDetails/biblio?DB=worldwide.espacenet.com&II=0&ND=3&adjacent=true&locale=en_EP&FT=D&date=20110519&CC=WO&NR=2011058331A1&KC=A1 DMPXKOE DI DMPXKOE DMPXKOE DN A839977 DMPXKOE MI TT473XN DMPXKOE MN P2X purinoceptor 7 (P2RX7) DMPXKOE MT DTT DMPXKOE MA Antagonist DMPXKOE RN The antihyperalgesic activity of a selective P2X7 receptor antagonist, A-839977, is lost in IL-1alphabeta knockout mice. Behav Brain Res. 2009 Dec 1;204(1):77-81. DMPXKOE RU https://pubmed.ncbi.nlm.nih.gov/19464323 DM5TDEW DI DM5TDEW DM5TDEW DN A-846714 DM5TDEW MI TTXJ178 DM5TDEW MN Histamine H4 receptor (H4R) DM5TDEW MT DTT DM5TDEW MA Inhibitor DM5TDEW RN Rotationally constrained 2,4-diamino-5,6-disubstituted pyrimidines: a new class of histamine H4 receptor antagonists with improved druglikeness and... J Med Chem. 2008 Oct 23;51(20):6547-57. DM5TDEW RU https://pubmed.ncbi.nlm.nih.gov/18817367 DMJBPR3 DI DMJBPR3 DMJBPR3 DN A-849531 DMJBPR3 MI TTN7BL9 DMJBPR3 MN Corticosteroid 11-beta-dehydrogenase 1 (HSD11B1) DMJBPR3 MT DTT DMJBPR3 MA Inhibitor DMJBPR3 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2763). DMJBPR3 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2763 DMJCPSD DI DMJCPSD DMJCPSD DN A-850002 DMJCPSD MI TTVBPDM DMJCPSD MN Metabotropic glutamate receptor 1 (mGluR1) DMJCPSD MT DTT DMJCPSD MA Modulator (allosteric modulator) DMJCPSD RN Structure-activity relationship of triazafluorenone derivatives as potent and selective mGluR1 antagonists. J Med Chem. 2005 Nov 17;48(23):7374-88. DMJCPSD RU https://pubmed.ncbi.nlm.nih.gov/16279797 DM96F8U DI DM96F8U DM96F8U DN A-867744 DM96F8U MI TTH18TF DM96F8U MN Muscarinic acetylcholine receptor M5 (CHRM5) DM96F8U MT DTT DM96F8U MA Blocker (channel blocker) DM96F8U RN In vitro pharmacological characterization of a novel allosteric modulator of alpha 7 neuronal acetylcholine receptor, 4-(5-(4-chlorophenyl)-2-methy... J Pharmacol Exp Ther. 2009 Jul;330(1):257-67. DM96F8U RU https://pubmed.ncbi.nlm.nih.gov/19389923 DM96F8U DI DM96F8U DM96F8U DN A-867744 DM96F8U MI TTLA931 DM96F8U MN Neuronal acetylcholine receptor alpha-7 (CHRNA7) DM96F8U MT DTT DM96F8U MA Modulator (allosteric modulator) DM96F8U RN In vitro pharmacological characterization of a novel allosteric modulator of alpha 7 neuronal acetylcholine receptor, 4-(5-(4-chlorophenyl)-2-methy... J Pharmacol Exp Ther. 2009 Jul;330(1):257-67. DM96F8U RU https://pubmed.ncbi.nlm.nih.gov/19389923 DM96F8U DI DM96F8U DM96F8U DN A-867744 DM96F8U MI TT5KPZR DM96F8U MN Neuronal acetylcholine receptor beta-2 (CHRNB2) DM96F8U MT DTT DM96F8U MA Blocker (channel blocker) DM96F8U RN In vitro pharmacological characterization of a novel allosteric modulator of alpha 7 neuronal acetylcholine receptor, 4-(5-(4-chlorophenyl)-2-methy... J Pharmacol Exp Ther. 2009 Jul;330(1):257-67. DM96F8U RU https://pubmed.ncbi.nlm.nih.gov/19389923 DM8IWUE DI DM8IWUE DM8IWUE DN A-887755 DM8IWUE MI TTE4KHA DM8IWUE MN Amyloid beta A4 protein (APP) DM8IWUE MT DTT DM8IWUE MA Inhibitor DM8IWUE RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2402). DM8IWUE RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2402 DMBF1OY DI DMBF1OY DMBF1OY DN A-935142 DMBF1OY MI TTQ6VDM DMBF1OY MN Voltage-gated potassium channel Kv11.1 (KCNH2) DMBF1OY MT DTT DMBF1OY MA Activator DMBF1OY RN Electrophysiologic characterization of a novel hERG channel activator. Biochem Pharmacol. 2009 Apr 15;77(8):1383-90. DMBF1OY RU https://pubmed.ncbi.nlm.nih.gov/19426677 DMROD7Q DI DMROD7Q DMROD7Q DN A-943931 DMROD7Q MI TTXJ178 DMROD7Q MN Histamine H4 receptor (H4R) DMROD7Q MT DTT DMROD7Q MA Inhibitor DMROD7Q RN Rotationally constrained 2,4-diamino-5,6-disubstituted pyrimidines: a new class of histamine H4 receptor antagonists with improved druglikeness and... J Med Chem. 2008 Oct 23;51(20):6547-57. DMROD7Q RU https://pubmed.ncbi.nlm.nih.gov/18817367 DMOY7TF DI DMOY7TF DMOY7TF DN A-967079 DMOY7TF MI TTELV3W DMOY7TF MN Transformation-sensitive protein p120 (TRPA1) DMOY7TF MT DTT DMOY7TF MA Antagonist DMOY7TF RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 485). DMOY7TF RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=485 DMU34BK DI DMU34BK DMU34BK DN A-987306 DMU34BK MI TTSQIFT DMU34BK MN 5-HT 1A receptor (HTR1A) DMU34BK MT DTT DMU34BK MA Inhibitor DMU34BK RN cis-4-(Piperazin-1-yl)-5,6,7a,8,9,10,11,11a-octahydrobenzofuro[2,3-h]quinazolin-2-amine (A-987306), a new histamine H4R antagonist that blocks pain... J Med Chem. 2008 Nov 27;51(22):7094-8. DMU34BK RU https://pubmed.ncbi.nlm.nih.gov/18983139 DMU34BK DI DMU34BK DMU34BK DN A-987306 DMU34BK MI TTK8CXU DMU34BK MN 5-HT 1B receptor (HTR1B) DMU34BK MT DTT DMU34BK MA Inhibitor DMU34BK RN cis-4-(Piperazin-1-yl)-5,6,7a,8,9,10,11,11a-octahydrobenzofuro[2,3-h]quinazolin-2-amine (A-987306), a new histamine H4R antagonist that blocks pain... J Med Chem. 2008 Nov 27;51(22):7094-8. DMU34BK RU https://pubmed.ncbi.nlm.nih.gov/18983139 DMU34BK DI DMU34BK DMU34BK DN A-987306 DMU34BK MI TTJQOD7 DMU34BK MN 5-HT 2A receptor (HTR2A) DMU34BK MT DTT DMU34BK MA Inhibitor DMU34BK RN cis-4-(Piperazin-1-yl)-5,6,7a,8,9,10,11,11a-octahydrobenzofuro[2,3-h]quinazolin-2-amine (A-987306), a new histamine H4R antagonist that blocks pain... J Med Chem. 2008 Nov 27;51(22):7094-8. DMU34BK RU https://pubmed.ncbi.nlm.nih.gov/18983139 DMU34BK DI DMU34BK DMU34BK DN A-987306 DMU34BK MI TT0K1SC DMU34BK MN 5-HT 2B receptor (HTR2B) DMU34BK MT DTT DMU34BK MA Inhibitor DMU34BK RN cis-4-(Piperazin-1-yl)-5,6,7a,8,9,10,11,11a-octahydrobenzofuro[2,3-h]quinazolin-2-amine (A-987306), a new histamine H4R antagonist that blocks pain... J Med Chem. 2008 Nov 27;51(22):7094-8. DMU34BK RU https://pubmed.ncbi.nlm.nih.gov/18983139 DMU34BK DI DMU34BK DMU34BK DN A-987306 DMU34BK MI TTPC4TU DMU34BK MN 5-HT 3A receptor (HTR3A) DMU34BK MT DTT DMU34BK MA Inhibitor DMU34BK RN cis-4-(Piperazin-1-yl)-5,6,7a,8,9,10,11,11a-octahydrobenzofuro[2,3-h]quinazolin-2-amine (A-987306), a new histamine H4R antagonist that blocks pain... J Med Chem. 2008 Nov 27;51(22):7094-8. DMU34BK RU https://pubmed.ncbi.nlm.nih.gov/18983139 DMU34BK DI DMU34BK DMU34BK DN A-987306 DMU34BK MI TTK25J1 DMU34BK MN Adenosine A1 receptor (ADORA1) DMU34BK MT DTT DMU34BK MA Inhibitor DMU34BK RN cis-4-(Piperazin-1-yl)-5,6,7a,8,9,10,11,11a-octahydrobenzofuro[2,3-h]quinazolin-2-amine (A-987306), a new histamine H4R antagonist that blocks pain... J Med Chem. 2008 Nov 27;51(22):7094-8. DMU34BK RU https://pubmed.ncbi.nlm.nih.gov/18983139 DMU34BK DI DMU34BK DMU34BK DN A-987306 DMU34BK MI TTC24WT DMU34BK MN C-C chemokine receptor type 1 (CCR1) DMU34BK MT DTT DMU34BK MA Inhibitor DMU34BK RN cis-4-(Piperazin-1-yl)-5,6,7a,8,9,10,11,11a-octahydrobenzofuro[2,3-h]quinazolin-2-amine (A-987306), a new histamine H4R antagonist that blocks pain... J Med Chem. 2008 Nov 27;51(22):7094-8. DMU34BK RU https://pubmed.ncbi.nlm.nih.gov/18983139 DMU34BK DI DMU34BK DMU34BK DN A-987306 DMU34BK MI TT4C8EA DMU34BK MN Dopamine D3 receptor (D3R) DMU34BK MT DTT DMU34BK MA Inhibitor DMU34BK RN cis-4-(Piperazin-1-yl)-5,6,7a,8,9,10,11,11a-octahydrobenzofuro[2,3-h]quinazolin-2-amine (A-987306), a new histamine H4R antagonist that blocks pain... J Med Chem. 2008 Nov 27;51(22):7094-8. DMU34BK RU https://pubmed.ncbi.nlm.nih.gov/18983139 DMU34BK DI DMU34BK DMU34BK DN A-987306 DMU34BK MI TTZ9SOR DMU34BK MN Muscarinic acetylcholine receptor M1 (CHRM1) DMU34BK MT DTT DMU34BK MA Inhibitor DMU34BK RN cis-4-(Piperazin-1-yl)-5,6,7a,8,9,10,11,11a-octahydrobenzofuro[2,3-h]quinazolin-2-amine (A-987306), a new histamine H4R antagonist that blocks pain... J Med Chem. 2008 Nov 27;51(22):7094-8. DMU34BK RU https://pubmed.ncbi.nlm.nih.gov/18983139 DMU34BK DI DMU34BK DMU34BK DN A-987306 DMU34BK MI TTYEG6Q DMU34BK MN Muscarinic acetylcholine receptor M2 (CHRM2) DMU34BK MT DTT DMU34BK MA Inhibitor DMU34BK RN cis-4-(Piperazin-1-yl)-5,6,7a,8,9,10,11,11a-octahydrobenzofuro[2,3-h]quinazolin-2-amine (A-987306), a new histamine H4R antagonist that blocks pain... J Med Chem. 2008 Nov 27;51(22):7094-8. DMU34BK RU https://pubmed.ncbi.nlm.nih.gov/18983139 DMU34BK DI DMU34BK DMU34BK DN A-987306 DMU34BK MI TTQ13Z5 DMU34BK MN Muscarinic acetylcholine receptor M3 (CHRM3) DMU34BK MT DTT DMU34BK MA Inhibitor DMU34BK RN cis-4-(Piperazin-1-yl)-5,6,7a,8,9,10,11,11a-octahydrobenzofuro[2,3-h]quinazolin-2-amine (A-987306), a new histamine H4R antagonist that blocks pain... J Med Chem. 2008 Nov 27;51(22):7094-8. DMU34BK RU https://pubmed.ncbi.nlm.nih.gov/18983139 DMU34BK DI DMU34BK DMU34BK DN A-987306 DMU34BK MI TTQ3JTF DMU34BK MN Muscarinic acetylcholine receptor M4 (CHRM4) DMU34BK MT DTT DMU34BK MA Inhibitor DMU34BK RN cis-4-(Piperazin-1-yl)-5,6,7a,8,9,10,11,11a-octahydrobenzofuro[2,3-h]quinazolin-2-amine (A-987306), a new histamine H4R antagonist that blocks pain... J Med Chem. 2008 Nov 27;51(22):7094-8. DMU34BK RU https://pubmed.ncbi.nlm.nih.gov/18983139 DMU34BK DI DMU34BK DMU34BK DN A-987306 DMU34BK MI TTYO0A3 DMU34BK MN Substance-K receptor (TACR2) DMU34BK MT DTT DMU34BK MA Inhibitor DMU34BK RN cis-4-(Piperazin-1-yl)-5,6,7a,8,9,10,11,11a-octahydrobenzofuro[2,3-h]quinazolin-2-amine (A-987306), a new histamine H4R antagonist that blocks pain... J Med Chem. 2008 Nov 27;51(22):7094-8. DMU34BK RU https://pubmed.ncbi.nlm.nih.gov/18983139 DMU34BK DI DMU34BK DMU34BK DN A-987306 DMU34BK MI TT4TFGN DMU34BK MN Vasopressin V1a receptor (V1AR) DMU34BK MT DTT DMU34BK MA Inhibitor DMU34BK RN cis-4-(Piperazin-1-yl)-5,6,7a,8,9,10,11,11a-octahydrobenzofuro[2,3-h]quinazolin-2-amine (A-987306), a new histamine H4R antagonist that blocks pain... J Med Chem. 2008 Nov 27;51(22):7094-8. DMU34BK RU https://pubmed.ncbi.nlm.nih.gov/18983139 DME4ULA DI DME4ULA DME4ULA DN A-993610 DME4ULA MI TTMI6F5 DME4ULA MN Transient receptor potential cation channel V1 (TRPV1) DME4ULA MT DTT DME4ULA MA Blocker DME4ULA RN Analgesic potential of TRPV1 antagonists. Biochem Pharmacol. 2009 Aug 1;78(3):211-6. DME4ULA RU https://pubmed.ncbi.nlm.nih.gov/19481638 DMW73A8 DI DMW73A8 DMW73A8 DN AA-123 DMW73A8 MI TTGKF90 DMW73A8 MN Bone morphogenetic protein receptor (BMPR2) DMW73A8 MT DTT DMW73A8 MA Agonist DMW73A8 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1794). DMW73A8 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1794 DM2BMAZ DI DM2BMAZ DM2BMAZ DN AA-166 DM2BMAZ MI TTGKF90 DM2BMAZ MN Bone morphogenetic protein receptor (BMPR2) DM2BMAZ MT DTT DM2BMAZ MA Agonist DM2BMAZ RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1794). DM2BMAZ RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1794 DMCN4ZD DI DMCN4ZD DMCN4ZD DN AA-184 DMCN4ZD MI TTGKF90 DMCN4ZD MN Bone morphogenetic protein receptor (BMPR2) DMCN4ZD MT DTT DMCN4ZD MA Agonist DMCN4ZD RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1794). DMCN4ZD RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1794 DMBGTX9 DI DMBGTX9 DMBGTX9 DN AA-204 DMBGTX9 MI TTGKF90 DMBGTX9 MN Bone morphogenetic protein receptor (BMPR2) DMBGTX9 MT DTT DMBGTX9 MA Agonist DMBGTX9 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1794). DMBGTX9 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1794 DMI59T7 DI DMI59T7 DMI59T7 DN AA-29504 DMI59T7 MI TTEX6LM DMI59T7 MN GABA(A) receptor gamma-3 (GABRG3) DMI59T7 MT DTT DMI59T7 MA Modulator DMI59T7 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 415). DMI59T7 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=415 DMNO51B DI DMNO51B DMNO51B DN AAE-M-PBP-amine DMNO51B MI TT0WAIE DMNO51B MN Melatonin receptor type 1A (MTNR1A) DMNO51B MT DTT DMNO51B MA Agonist DMNO51B RN MT1-selective melatonin receptor ligands: synthesis, pharmacological evaluation, and molecular dynamics investigation of N-{[(3-O-substituted)anilino]alkyl}amides. ChemMedChem. 2012 Nov;7(11):1954-64. DMNO51B RU https://pubmed.ncbi.nlm.nih.gov/22927210 DM35RFH DI DM35RFH DM35RFH DN AAL-993 DM35RFH MI TTRLW2X DM35RFH MN Fibroblast growth factor receptor 1 (FGFR1) DM35RFH MT DTT DM35RFH MA Inhibitor DM35RFH RN Anthranilic acid amides: a novel class of antiangiogenic VEGF receptor kinase inhibitors. J Med Chem. 2002 Dec 19;45(26):5687-93. DM35RFH RU https://pubmed.ncbi.nlm.nih.gov/12477352 DM35RFH DI DM35RFH DM35RFH DN AAL-993 DM35RFH MI TT2Q6G1 DM35RFH MN Vascular endothelial growth factor receptor 1 (FLT-1) DM35RFH MT DTT DM35RFH MA Inhibitor DM35RFH RN Anthranilic acid amides: a novel class of antiangiogenic VEGF receptor kinase inhibitors. J Med Chem. 2002 Dec 19;45(26):5687-93. DM35RFH RU https://pubmed.ncbi.nlm.nih.gov/12477352 DM35RFH DI DM35RFH DM35RFH DN AAL-993 DM35RFH MI TTUTJGQ DM35RFH MN Vascular endothelial growth factor receptor 2 (KDR) DM35RFH MT DTT DM35RFH MA Inhibitor DM35RFH RN Anthranilic acid amides: a novel class of antiangiogenic VEGF receptor kinase inhibitors. J Med Chem. 2002 Dec 19;45(26):5687-93. DM35RFH RU https://pubmed.ncbi.nlm.nih.gov/12477352 DM35RFH DI DM35RFH DM35RFH DN AAL-993 DM35RFH MI TT1VAUK DM35RFH MN VEGFR1 messenger RNA (VEGFR1 mRNA) DM35RFH MT DTT DM35RFH MA Inhibitor DM35RFH RN Inhibitors of VEGF receptors-1 and -2 based on the 2-((pyridin-4-yl)ethyl)pyridine template. Bioorg Med Chem Lett. 2006 Apr 1;16(7):1913-9. DM35RFH RU https://pubmed.ncbi.nlm.nih.gov/16460936 DMDBWT6 DI DMDBWT6 DMDBWT6 DN Abbott 14c DMDBWT6 MI TTWDC17 DMDBWT6 MN Growth hormone secretagogue receptor 1 (GHSR) DMDBWT6 MT DTT DMDBWT6 MA Antagonist DMDBWT6 RN Discovery and pharmacological evaluation of growth hormone secretagogue receptor antagonists. J Med Chem. 2006 Jul 27;49(15):4459-69. DMDBWT6 RU https://pubmed.ncbi.nlm.nih.gov/16854051 DMHRPAM DI DMHRPAM DMHRPAM DN ABBV-744 DMHRPAM MI TTNISW6 DMHRPAM MN HUMAN bromodomain-containing protein 2 (BRD2) DMHRPAM MT DTT DMHRPAM MA Inhibitor DMHRPAM RN Uncovering the Role of BRD2 in COVID-19. 2020-03-19 DMHRPAM RU https://www.caymanchem.com/news/uncovering-the-role-of-brd2-in-covid-19 DMA01OF DI DMA01OF DMA01OF DN ABC-4 DMA01OF MI TT5BR7T DMA01OF MN Fibroblast growth factor receptor 4 (FGFR4) DMA01OF MT DTT DMA01OF RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1811). DMA01OF RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1811 DM2AIE9 DI DM2AIE9 DM2AIE9 DN ABC-7 DM2AIE9 MI TTBQ3OC DM2AIE9 MN Macrophage-stimulating protein receptor (RON) DM2AIE9 MT DTT DM2AIE9 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1816). DM2AIE9 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1816 DMW1Y2G DI DMW1Y2G DMW1Y2G DN Abietic acid DMW1Y2G MI TTN7BL9 DMW1Y2G MN Corticosteroid 11-beta-dehydrogenase 1 (HSD11B1) DMW1Y2G MT DTT DMW1Y2G MA Inhibitor DMW1Y2G RN A rapid screening assay for inhibitors of 11beta-hydroxysteroid dehydrogenases (11beta-HSD): flavanone selectively inhibits 11beta-HSD1 reductase activity. Mol Cell Endocrinol. 2003 Dec 30;212(1-2):41-9. DMW1Y2G RU https://pubmed.ncbi.nlm.nih.gov/14654249 DM0LUOM DI DM0LUOM DM0LUOM DN ABIO 09-01 DM0LUOM MI TTFYL58 DM0LUOM MN CaM-kinase II (CAMK2) DM0LUOM MT DTT DM0LUOM MA Inhibitor DM0LUOM RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1558). DM0LUOM RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1558 DMRC3A5 DI DMRC3A5 DMRC3A5 DN ABL127 DMRC3A5 MI TTXQ54R DMRC3A5 MN Protein phosphatase methylesterase 1 (PME-1) DMRC3A5 MT DTT DMRC3A5 MA Inhibitor DMRC3A5 RN A high-throughput, multiplexed assay for superfamily-wide profiling of enzyme activity. Nat Chem Biol. 2014 Aug;10(8):656-63. DMRC3A5 RU https://pubmed.ncbi.nlm.nih.gov/24997602 DMKN10X DI DMKN10X DMKN10X DN Abloid DMKN10X MI TTE4KHA DMKN10X MN Amyloid beta A4 protein (APP) DMKN10X MT DTT DMKN10X MA Inhibitor DMKN10X RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2402). DMKN10X RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2402 DMQPHFU DI DMQPHFU DMQPHFU DN AB-MECA DMQPHFU MI TTNE7KG DMQPHFU MN Adenosine A2b receptor (ADORA2B) DMQPHFU MT DTT DMQPHFU MA Agonist DMQPHFU RN Comparative pharmacology of human adenosine receptor subtypes - characterization of stably transfected receptors in CHO cells. Naunyn Schmiedebergs Arch Pharmacol. 1998 Jan;357(1):1-9. DMQPHFU RU https://pubmed.ncbi.nlm.nih.gov/9459566 DMQPHFU DI DMQPHFU DMQPHFU DN AB-MECA DMQPHFU MI TTJFY5U DMQPHFU MN Adenosine A3 receptor (ADORA3) DMQPHFU MT DTT DMQPHFU MA Agonist DMQPHFU RN [(3)H]MRE 3008F20: a novel antagonist radioligand for the pharmacological and biochemical characterization of human A(3) adenosine receptors. Mol Pharmacol. 2000 May;57(5):968-75. DMQPHFU RU https://pubmed.ncbi.nlm.nih.gov/10779381 DME8G7F DI DME8G7F DME8G7F DN AB-NECA DME8G7F MI TTNE7KG DME8G7F MN Adenosine A2b receptor (ADORA2B) DME8G7F MT DTT DME8G7F MA Agonist DME8G7F RN Characterization of human A(2B) adenosine receptors: radioligand binding, western blotting, and coupling to G(q) in human embryonic kidney 293 cells and HMC-1 mast cells. Mol Pharmacol. 1999 Oct;56(4):705-13. DME8G7F RU https://pubmed.ncbi.nlm.nih.gov/10496952 DMV6DAO DI DMV6DAO DMV6DAO DN abnormal cannabidiol DMV6DAO MI TTNET8J DMV6DAO MN G-protein coupled receptor 55 (GPR55) DMV6DAO MT DTT DMV6DAO MA Agonist DMV6DAO RN The orphan receptor GPR55 is a novel cannabinoid receptor. Br J Pharmacol. 2007 Dec;152(7):1092-101. DMV6DAO RU https://pubmed.ncbi.nlm.nih.gov/17876302 DMV6DAO DI DMV6DAO DMV6DAO DN abnormal cannabidiol DMV6DAO MI TTSLJAR DMV6DAO MN N-arachidonyl glycine receptor (GPR18) DMV6DAO MT DTT DMV6DAO MA Agonist DMV6DAO RN Delta(9) -Tetrahydrocannabinol and N-arachidonyl glycine are full agonists at GPR18 receptors and induce migration in human endometrial HEC-1B cells. Br J Pharmacol. 2012 Apr;165(8):2414-24. DMV6DAO RU https://pubmed.ncbi.nlm.nih.gov/21595653 DMJ6MUE DI DMJ6MUE DMJ6MUE DN ABT-116 DMJ6MUE MI TTMI6F5 DMJ6MUE MN Transient receptor potential cation channel V1 (TRPV1) DMJ6MUE MT DTT DMJ6MUE MA Antagonist DMJ6MUE RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 507). DMJ6MUE RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=507 DMZ3YTO DI DMZ3YTO DMZ3YTO DN ABT-341 DMZ3YTO MI TTDIGC1 DMZ3YTO MN Dipeptidyl peptidase 4 (DPP-4) DMZ3YTO MT DTT DMZ3YTO MA Inhibitor DMZ3YTO RN Discovery of ((4R,5S)-5-amino-4-(2,4,5- trifluorophenyl)cyclohex-1-enyl)-(3- (trifluoromethyl)-5,6-dihydro- [1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)... J Med Chem. 2006 Nov 2;49(22):6439-42. DMZ3YTO RU https://pubmed.ncbi.nlm.nih.gov/17064063 DM6J57N DI DM6J57N DM6J57N DN ABT-670 DM6J57N MI TTE0A2F DM6J57N MN Dopamine D4 receptor (D4R) DM6J57N MT DTT DM6J57N MA Inhibitor DM6J57N RN Discovery of 3-methyl-N-(1-oxy-3',4',5',6'-tetrahydro-2'H-[2,4'-bipyridine]-1'-ylmethyl)benzamide (ABT-670), an orally bioavailable dopamine D4 ago... J Med Chem. 2006 Dec 14;49(25):7450-65. DM6J57N RU https://pubmed.ncbi.nlm.nih.gov/17149874 DM79DSN DI DM79DSN DM79DSN DN ABTAA DM79DSN MI TT9VGXW DM79DSN MN Angiopoietin 1 receptor (TEK) DM79DSN MT DTT DM79DSN MA Activator DM79DSN RN Amelioration of sepsis by TIE2 activation-induced vascular protection. Sci Transl Med. 2016 Apr 20;8(335):335ra55. DM79DSN RU https://pubmed.ncbi.nlm.nih.gov/27099174 DM79DSN DI DM79DSN DM79DSN DN ABTAA DM79DSN MI TTKLQTJ DM79DSN MN Angiopoietin-2 (ANGPT2) DM79DSN MT DTT DM79DSN MA Binder DM79DSN RN Amelioration of sepsis by TIE2 activation-induced vascular protection. Sci Transl Med. 2016 Apr 20;8(335):335ra55. DM79DSN RU https://pubmed.ncbi.nlm.nih.gov/27099174 DMC02FP DI DMC02FP DMC02FP DN Abyssinin I DMC02FP MI TTELIN2 DMC02FP MN PTPN1 messenger RNA (PTPN1 mRNA) DMC02FP MT DTT DMC02FP MA Inhibitor DMC02FP RN Isoprenylated flavonoids from the stem bark of Erythrina abyssinica. J Nat Prod. 2007 Jun;70(6):1039-42. DMC02FP RU https://pubmed.ncbi.nlm.nih.gov/17489632 DMR7IGZ DI DMR7IGZ DMR7IGZ DN Abyssinin II DMR7IGZ MI TTELIN2 DMR7IGZ MN PTPN1 messenger RNA (PTPN1 mRNA) DMR7IGZ MT DTT DMR7IGZ MA Inhibitor DMR7IGZ RN Isoprenylated flavonoids from the stem bark of Erythrina abyssinica. J Nat Prod. 2007 Jun;70(6):1039-42. DMR7IGZ RU https://pubmed.ncbi.nlm.nih.gov/17489632 DMEYQF9 DI DMEYQF9 DMEYQF9 DN Abyssinoflavanone VI DMEYQF9 MI TTELIN2 DMEYQF9 MN PTPN1 messenger RNA (PTPN1 mRNA) DMEYQF9 MT DTT DMEYQF9 MA Inhibitor DMEYQF9 RN Isoprenylated flavonoids from the stem bark of Erythrina abyssinica. J Nat Prod. 2007 Jun;70(6):1039-42. DMEYQF9 RU https://pubmed.ncbi.nlm.nih.gov/17489632 DMTVQSL DI DMTVQSL DMTVQSL DN Abyssinoflavanone VII DMTVQSL MI TTELIN2 DMTVQSL MN PTPN1 messenger RNA (PTPN1 mRNA) DMTVQSL MT DTT DMTVQSL MA Inhibitor DMTVQSL RN Isoprenylated flavonoids from the stem bark of Erythrina abyssinica. J Nat Prod. 2007 Jun;70(6):1039-42. DMTVQSL RU https://pubmed.ncbi.nlm.nih.gov/17489632 DMH3CK2 DI DMH3CK2 DMH3CK2 DN ABYSSINONE V DMH3CK2 MI TT9V5JH DMH3CK2 MN Phospholipase A2 (PLA2G1B) DMH3CK2 MT DTT DMH3CK2 MA Inhibitor DMH3CK2 RN Phospholipase A2 Inhibitors from an Erythrina Species from Samoa J. Nat. Prod. 60(6):537-539 (1997). DMH3CK2 RU http://pubs.acs.org/doi/abs/10.1021/np960533e DM9YAVX DI DM9YAVX DM9YAVX DN Abyssinone-IV DM9YAVX MI TTELIN2 DM9YAVX MN PTPN1 messenger RNA (PTPN1 mRNA) DM9YAVX MT DTT DM9YAVX MA Inhibitor DM9YAVX RN Protein tyrosine phosphatase-1B inhibitory activity of isoprenylated flavonoids isolated from Erythrina mildbraedii. J Nat Prod. 2006 Nov;69(11):1572-6. DM9YAVX RU https://pubmed.ncbi.nlm.nih.gov/17125223 DMZUY93 DI DMZUY93 DMZUY93 DN Abyssinone-VI-4-O-methyl ether DMZUY93 MI TTELIN2 DMZUY93 MN PTPN1 messenger RNA (PTPN1 mRNA) DMZUY93 MT DTT DMZUY93 MA Inhibitor DMZUY93 RN Protein tyrosine phosphatase-1B inhibitory activity of isoprenylated flavonoids isolated from Erythrina mildbraedii. J Nat Prod. 2006 Nov;69(11):1572-6. DMZUY93 RU https://pubmed.ncbi.nlm.nih.gov/17125223 DMZ0RP5 DI DMZ0RP5 DMZ0RP5 DN AC-(D)PHE-PRO-BOROHOMOLYS-OH DMZ0RP5 MI TT6L509 DMZ0RP5 MN Coagulation factor IIa (F2) DMZ0RP5 MT DTT DMZ0RP5 MA Inhibitor DMZ0RP5 RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DMZ0RP5 RU https://pubmed.ncbi.nlm.nih.gov/10592235 DMPHV7K DI DMPHV7K DMPHV7K DN AC-(D)PHE-PRO-BOROHOMOORNITHINE-OH DMPHV7K MI TT6L509 DMPHV7K MN Coagulation factor IIa (F2) DMPHV7K MT DTT DMPHV7K MA Inhibitor DMPHV7K RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DMPHV7K RU https://pubmed.ncbi.nlm.nih.gov/10592235 DM2YWRL DI DM2YWRL DM2YWRL DN AC-(D)PHE-PRO-BOROLYS-OH DM2YWRL MI TT6L509 DM2YWRL MN Coagulation factor IIa (F2) DM2YWRL MT DTT DM2YWRL MA Inhibitor DM2YWRL RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DM2YWRL RU https://pubmed.ncbi.nlm.nih.gov/10592235 DMRLOGP DI DMRLOGP DMRLOGP DN Ac-[CEHdFRWC]-NH2 DMRLOGP MI TT0MV2T DMRLOGP MN Melanocortin receptor 1 (MC1R) DMRLOGP MT DTT DMRLOGP MA Inhibitor DMRLOGP RN Discovery of a beta-MSH-derived MC-4R selective agonist. J Med Chem. 2005 May 5;48(9):3095-8. DMRLOGP RU https://pubmed.ncbi.nlm.nih.gov/15857110 DMRLOGP DI DMRLOGP DMRLOGP DN Ac-[CEHdFRWC]-NH2 DMRLOGP MI TTNI91K DMRLOGP MN Melanocortin receptor 3 (MC3R) DMRLOGP MT DTT DMRLOGP MA Inhibitor DMRLOGP RN Discovery of a beta-MSH-derived MC-4R selective agonist. J Med Chem. 2005 May 5;48(9):3095-8. DMRLOGP RU https://pubmed.ncbi.nlm.nih.gov/15857110 DMRLOGP DI DMRLOGP DMRLOGP DN Ac-[CEHdFRWC]-NH2 DMRLOGP MI TTD0CIQ DMRLOGP MN Melanocortin receptor 4 (MC4R) DMRLOGP MT DTT DMRLOGP MA Inhibitor DMRLOGP RN Discovery of a beta-MSH-derived MC-4R selective agonist. J Med Chem. 2005 May 5;48(9):3095-8. DMRLOGP RU https://pubmed.ncbi.nlm.nih.gov/15857110 DM9IN4T DI DM9IN4T DM9IN4T DN Ac-[CFWKFC]-NH2 DM9IN4T MI TTW5UDX DM9IN4T MN Urotensin II receptor (UTS2R) DM9IN4T MT DTT DM9IN4T MA Inhibitor DM9IN4T RN Urotensin-II receptor modulators as potential drugs. J Med Chem. 2010 Apr 8;53(7):2695-708. DM9IN4T RU https://pubmed.ncbi.nlm.nih.gov/20043680 DMW24UH DI DMW24UH DMW24UH DN Ac-[CFWkYC]-NH2 DMW24UH MI TTW5UDX DMW24UH MN Urotensin II receptor (UTS2R) DMW24UH MT DTT DMW24UH MA Inhibitor DMW24UH RN Urotensin-II receptor modulators as potential drugs. J Med Chem. 2010 Apr 8;53(7):2695-708. DMW24UH RU https://pubmed.ncbi.nlm.nih.gov/20043680 DMFKV97 DI DMFKV97 DMFKV97 DN AC1LG8KT DMFKV97 MI TT3IVG2 DMFKV97 MN JNK2 messenger RNA (JNK2 mRNA) DMFKV97 MT DTT DMFKV97 MA Inhibitor DMFKV97 RN N-(3-Cyano-4,5,6,7-tetrahydro-1-benzothien-2-yl)amides as potent, selective, inhibitors of JNK2 and JNK3. Bioorg Med Chem Lett. 2007 Mar 1;17(5):1296-301. DMFKV97 RU https://pubmed.ncbi.nlm.nih.gov/17194588 DMFKV97 DI DMFKV97 DMFKV97 DN AC1LG8KT DMFKV97 MI TT056SO DMFKV97 MN Stress-activated protein kinase JNK3 (JNK3) DMFKV97 MT DTT DMFKV97 MA Inhibitor DMFKV97 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1498). DMFKV97 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1498 DMSKE1I DI DMSKE1I DMSKE1I DN AC261066 DMSKE1I MI TTISP28 DMSKE1I MN Retinoic acid receptor beta (RARB) DMSKE1I MT DTT DMSKE1I MA Agonist DMSKE1I RN Discovery of a potent, orally available, and isoform-selective retinoic acid beta2 receptor agonist. J Med Chem. 2005 Dec 1;48(24):7517-9. DMSKE1I RU https://pubmed.ncbi.nlm.nih.gov/16302793 DM4G60V DI DM4G60V DM4G60V DN AC265347 DM4G60V MI TTBUYHA DM4G60V MN Extracellular calcium-sensing receptor (CASR) DM4G60V MT DTT DM4G60V MA Modulator (allosteric modulator) DM4G60V RN Characterization of highly efficacious allosteric agonists of the human calcium-sensing receptor. J Pharmacol Exp Ther. 2011 Apr;337(1):275-84. DM4G60V RU https://pubmed.ncbi.nlm.nih.gov/21239511 DMNUE4H DI DMNUE4H DMNUE4H DN AC-3174 DMNUE4H MI TTVIMDE DMNUE4H MN Glucagon-like peptide 1 receptor (GLP1R) DMNUE4H MT DTT DMNUE4H MA Agonist DMNUE4H RN 2005 approvals: Safety first. Nature Reviews Drug Discovery 5, 92-93 (February 2006). DMNUE4H RU http://www.nature.com/nrd/journal/v11/n1/full/nrd3645.html DM4JNY9 DI DM4JNY9 DM4JNY9 DN AC55649 DM4JNY9 MI TTISP28 DM4JNY9 MN Retinoic acid receptor beta (RARB) DM4JNY9 MT DTT DM4JNY9 MA Agonist DM4JNY9 RN Discovery of a potent, orally available, and isoform-selective retinoic acid beta2 receptor agonist. J Med Chem. 2005 Dec 1;48(24):7517-9. DM4JNY9 RU https://pubmed.ncbi.nlm.nih.gov/16302793 DMXS72J DI DMXS72J DMXS72J DN AC-710 DMXS72J MI TTC70AJ DMXS72J MN Granulocyte colony-stimulating factor receptor (G-CSF-R) DMXS72J MT DTT DMXS72J MA Inhibitor DMXS72J RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1719). DMXS72J RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1719 DM367MF DI DM367MF DM367MF DN AC-7954 DM367MF MI TTW5UDX DM367MF MN Urotensin II receptor (UTS2R) DM367MF MT DTT DM367MF MA Agonist DM367MF RN Isochromanone-based urotensin-II receptor agonists. Bioorg Med Chem. 2005 Apr 15;13(8):3057-68. DM367MF RU https://pubmed.ncbi.nlm.nih.gov/15781415 DM09BJ4 DI DM09BJ4 DM09BJ4 DN AC-8632 DM09BJ4 MI TTY84UG DM09BJ4 MN Acetyl-CoA carboxylase 2 (ACACB) DM09BJ4 MT DTT DM09BJ4 MA Inhibitor DM09BJ4 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1264). DM09BJ4 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1264 DM09BJ4 DI DM09BJ4 DM09BJ4 DN AC-8632 DM09BJ4 MI TTYAWV0 DM09BJ4 MN Plasmodium Acetyl-CoA carboxylase 1 (Malaria ACC1) DM09BJ4 MT DTT DM09BJ4 MA Inhibitor DM09BJ4 RN Reduced food intake and body weight in mice treated with fatty acid synthase inhibitors. Science. 2000 Jun 30;288(5475):2379-81. DM09BJ4 RU https://pubmed.ncbi.nlm.nih.gov/10875926 DMACYPW DI DMACYPW DMACYPW DN ACAA DMACYPW MI TTEBMN7 DMACYPW MN Long transient receptor potential channel 2 (TRPM2) DMACYPW MT DTT DMACYPW MA Blocker (channel blocker) DMACYPW RN Inhibition of TRPM2 cation channels by N-(p-amylcinnamoyl)anthranilic acid. Br J Pharmacol. 2006 Jun;148(3):264-73. DMACYPW RU https://pubmed.ncbi.nlm.nih.gov/16604090 DMACYPW DI DMACYPW DMACYPW DN ACAA DMACYPW MI TTXDKTO DMACYPW MN Long transient receptor potential channel 8 (TRPM8) DMACYPW MT DTT DMACYPW MA Blocker (channel blocker) DMACYPW RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 500). DMACYPW RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=500 DMACYPW DI DMACYPW DMACYPW DN ACAA DMACYPW MI TTNVC34 DMACYPW MN Short transient receptor potential channel 3 (TRPC3) DMACYPW MT DTT DMACYPW MA Blocker (channel blocker) DMACYPW RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 488). DMACYPW RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=488 DMACYPW DI DMACYPW DMACYPW DN ACAA DMACYPW MI TTRBT3W DMACYPW MN Short transient receptor potential channel 6 (TRPC6) DMACYPW MT DTT DMACYPW MA Blocker (channel blocker) DMACYPW RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 491). DMACYPW RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=491 DMQOB0X DI DMQOB0X DMQOB0X DN Acacetin DMQOB0X MI TT2J34L DMQOB0X MN Arachidonate 5-lipoxygenase (5-LOX) DMQOB0X MT DTT DMQOB0X MA Inhibitor DMQOB0X RN Novel and known constituents from Buddleja species and their activity against leukocyte eicosanoid generation. J Nat Prod. 1999 Sep;62(9):1241-5. DMQOB0X RU https://pubmed.ncbi.nlm.nih.gov/10514305 DMQOB0X DI DMQOB0X DMQOB0X DN Acacetin DMQOB0X MI TTI84H7 DMQOB0X MN Cytochrome P450 1B1 (CYP1B1) DMQOB0X MT DTT DMQOB0X MA Inhibitor DMQOB0X RN Selective inhibition of methoxyflavonoids on human CYP1B1 activity. Bioorg Med Chem. 2010 Sep 1;18(17):6310-5. DMQOB0X RU https://pubmed.ncbi.nlm.nih.gov/20696580 DMQOB0X DI DMQOB0X DMQOB0X DN Acacetin DMQOB0X MI TT7RJY8 DMQOB0X MN Xanthine dehydrogenase/oxidase (XDH) DMQOB0X MT DTT DMQOB0X MA Inhibitor DMQOB0X RN Inhibition of cow's milk xanthine oxidase by flavonoids. J Nat Prod. 1988 Mar-Apr;51(2):345-8. DMQOB0X RU https://pubmed.ncbi.nlm.nih.gov/3379415 DMJ3C20 DI DMJ3C20 DMJ3C20 DN Ac-Ala-Pro-Val-(2-benzoxazole) DMJ3C20 MI TTPLTSQ DMJ3C20 MN Neutrophil elastase (NE) DMJ3C20 MT DTT DMJ3C20 MA Inhibitor DMJ3C20 RN Inhibitors of proteases and amide hydrolases that employ an alpha-ketoheterocycle as a key enabling functionality. Bioorg Med Chem. 2008 Feb 15;16(4):1562-95. DMJ3C20 RU https://pubmed.ncbi.nlm.nih.gov/18053726 DMZDFRI DI DMZDFRI DMZDFRI DN Acanthus ilicifolius Linn DMZDFRI MI TT2J34L DMZDFRI MN Arachidonate 5-lipoxygenase (5-LOX) DMZDFRI MT DTT DMZDFRI MA Inhibitor DMZDFRI RN Anti-inflammatory activity of Acanthus ilicifolius. J Ethnopharmacol. 2008 Oct 30;120(1):7-12. DMZDFRI RU https://pubmed.ncbi.nlm.nih.gov/18703126 DMZDFRI DI DMZDFRI DMZDFRI DN Acanthus ilicifolius Linn DMZDFRI MI TTCGSZ4 DMZDFRI MN Pancreatic alpha-amylase (AMY2A) DMZDFRI MT DTT DMZDFRI MA Inhibitor DMZDFRI RN Four acarviosin-containing oligosaccharides identified from Streptomyces coelicoflavus ZG0656 are potent inhibitors of alpha-amylase. Carbohydr Res. 2008 Apr 7;343(5):882-92. DMZDFRI RU https://pubmed.ncbi.nlm.nih.gov/18294624 DMS9COH DI DMS9COH DMS9COH DN Acarbose Derived Hexasaccharide DMS9COH MI TTCGSZ4 DMS9COH MN Pancreatic alpha-amylase (AMY2A) DMS9COH MT DTT DMS9COH MA Inhibitor DMS9COH RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMS9COH RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMYHADT DI DMYHADT DMYHADT DN Ac-Asp-Arg-Leu-Asp-Ser-OH DMYHADT MI TTT1R2L DMYHADT MN Integrin alpha-V (ITGAV) DMYHADT MT DTT DMYHADT MA Inhibitor DMYHADT RN Synthesis and biological evaluation of non-peptide alpha(v)beta(3)/alpha(5)beta(1) integrin dual antagonists containing 5,6-dihydropyridin-2-one sc... Bioorg Med Chem. 2007 Dec 1;15(23):7380-90. DMYHADT RU https://pubmed.ncbi.nlm.nih.gov/17869121 DMYHADT DI DMYHADT DMYHADT DN Ac-Asp-Arg-Leu-Asp-Ser-OH DMYHADT MI TTJA1ZO DMYHADT MN ITGB3 messenger RNA (ITGB3 mRNA) DMYHADT MT DTT DMYHADT MA Inhibitor DMYHADT RN Synthesis and biological evaluation of non-peptide alpha(v)beta(3)/alpha(5)beta(1) integrin dual antagonists containing 5,6-dihydropyridin-2-one sc... Bioorg Med Chem. 2007 Dec 1;15(23):7380-90. DMYHADT RU https://pubmed.ncbi.nlm.nih.gov/17869121 DMT74F5 DI DMT74F5 DMT74F5 DN AcAsp-D-Gla-Leu-Ile-Cha-Cys DMT74F5 MI TTWXB3E DMT74F5 MN Hepatitis C virus NS3 helicase (HCV NS3) DMT74F5 MT DTT DMT74F5 MA Inhibitor DMT74F5 RN Control of hepatitis C: a medicinal chemistry perspective. J Med Chem. 2005 Jan 13;48(1):1-20. DMT74F5 RU https://pubmed.ncbi.nlm.nih.gov/15633995 DMDC71B DI DMDC71B DMDC71B DN AcAsp-D-Glu-Leu-Glu-Cha-Cys DMDC71B MI TTWXB3E DMDC71B MN Hepatitis C virus NS3 helicase (HCV NS3) DMDC71B MT DTT DMDC71B MA Inhibitor DMDC71B RN Inhibition of hepatitis C virus NS3 protease activity by product-based peptides is dependent on helicase domain. Bioorg Med Chem Lett. 2001 Jan 22;11(2):203-6. DMDC71B RU https://pubmed.ncbi.nlm.nih.gov/11206459 DMXQATR DI DMXQATR DMXQATR DN AcAsp-Gla-Leu-Ile-Cha-Cys DMXQATR MI TTWXB3E DMXQATR MN Hepatitis C virus NS3 helicase (HCV NS3) DMXQATR MT DTT DMXQATR MA Inhibitor DMXQATR RN Inhibition of hepatitis C virus NS3 protease activity by product-based peptides is dependent on helicase domain. Bioorg Med Chem Lett. 2001 Jan 22;11(2):203-6. DMXQATR RU https://pubmed.ncbi.nlm.nih.gov/11206459 DMHZ5W3 DI DMHZ5W3 DMHZ5W3 DN AcAsp-Glu-Cha-Val-Prb-Cpg DMHZ5W3 MI TTWXB3E DMHZ5W3 MN Hepatitis C virus NS3 helicase (HCV NS3) DMHZ5W3 MT DTT DMHZ5W3 MA Inhibitor DMHZ5W3 RN Control of hepatitis C: a medicinal chemistry perspective. J Med Chem. 2005 Jan 13;48(1):1-20. DMHZ5W3 RU https://pubmed.ncbi.nlm.nih.gov/15633995 DMDH5EJ DI DMDH5EJ DMDH5EJ DN AcAsp-Glu-Cha-Val-Prb-Cys DMDH5EJ MI TTWXB3E DMDH5EJ MN Hepatitis C virus NS3 helicase (HCV NS3) DMDH5EJ MT DTT DMDH5EJ MA Inhibitor DMDH5EJ RN Control of hepatitis C: a medicinal chemistry perspective. J Med Chem. 2005 Jan 13;48(1):1-20. DMDH5EJ RU https://pubmed.ncbi.nlm.nih.gov/15633995 DMEB8UA DI DMEB8UA DMEB8UA DN AcAsp-Glu-Dif-Glu-Cha-Cys DMEB8UA MI TTWXB3E DMEB8UA MN Hepatitis C virus NS3 helicase (HCV NS3) DMEB8UA MT DTT DMEB8UA MA Inhibitor DMEB8UA RN Control of hepatitis C: a medicinal chemistry perspective. J Med Chem. 2005 Jan 13;48(1):1-20. DMEB8UA RU https://pubmed.ncbi.nlm.nih.gov/15633995 DMPQ8Z9 DI DMPQ8Z9 DMPQ8Z9 DN AcAsp-Glu-Dif-Glu-Cha-Fab DMPQ8Z9 MI TTWXB3E DMPQ8Z9 MN Hepatitis C virus NS3 helicase (HCV NS3) DMPQ8Z9 MT DTT DMPQ8Z9 MA Inhibitor DMPQ8Z9 RN Control of hepatitis C: a medicinal chemistry perspective. J Med Chem. 2005 Jan 13;48(1):1-20. DMPQ8Z9 RU https://pubmed.ncbi.nlm.nih.gov/15633995 DM6IP17 DI DM6IP17 DM6IP17 DN AcAsp-Glu-Dif-Ile-Cha-Cys DM6IP17 MI TTWXB3E DM6IP17 MN Hepatitis C virus NS3 helicase (HCV NS3) DM6IP17 MT DTT DM6IP17 MA Inhibitor DM6IP17 RN Inhibition of hepatitis C virus NS3 protease activity by product-based peptides is dependent on helicase domain. Bioorg Med Chem Lett. 2001 Jan 22;11(2):203-6. DM6IP17 RU https://pubmed.ncbi.nlm.nih.gov/11206459 DM3W68X DI DM3W68X DM3W68X DN AcAsp-Glu-Dif-Ile-Cha-Cys-Iqc-Nle-Thr-TyrNH2 DM3W68X MI TTWXB3E DM3W68X MN Hepatitis C virus NS3 helicase (HCV NS3) DM3W68X MT DTT DM3W68X MA Inhibitor DM3W68X RN Control of hepatitis C: a medicinal chemistry perspective. J Med Chem. 2005 Jan 13;48(1):1-20. DM3W68X RU https://pubmed.ncbi.nlm.nih.gov/15633995 DMCIJ6Q DI DMCIJ6Q DMCIJ6Q DN AcAsp-Glu-Dif-Ile-Cha-Cys-Pro-Cha-Asp-ValNH2 DMCIJ6Q MI TTWXB3E DMCIJ6Q MN Hepatitis C virus NS3 helicase (HCV NS3) DMCIJ6Q MT DTT DMCIJ6Q MA Inhibitor DMCIJ6Q RN Control of hepatitis C: a medicinal chemistry perspective. J Med Chem. 2005 Jan 13;48(1):1-20. DMCIJ6Q RU https://pubmed.ncbi.nlm.nih.gov/15633995 DMA7ZSY DI DMA7ZSY DMA7ZSY DN AcAsp-Glu-Dif-Ile-Cha-Cys-Pro-Nle-Asp-ValNH2 DMA7ZSY MI TTWXB3E DMA7ZSY MN Hepatitis C virus NS3 helicase (HCV NS3) DMA7ZSY MT DTT DMA7ZSY MA Inhibitor DMA7ZSY RN Control of hepatitis C: a medicinal chemistry perspective. J Med Chem. 2005 Jan 13;48(1):1-20. DMA7ZSY RU https://pubmed.ncbi.nlm.nih.gov/15633995 DM6PZ45 DI DM6PZ45 DM6PZ45 DN AcAsp-Glu-Dif-Lys-Cha-Cys DM6PZ45 MI TTWXB3E DM6PZ45 MN Hepatitis C virus NS3 helicase (HCV NS3) DM6PZ45 MT DTT DM6PZ45 MA Inhibitor DM6PZ45 RN Inhibition of hepatitis C virus NS3 protease activity by product-based peptides is dependent on helicase domain. Bioorg Med Chem Lett. 2001 Jan 22;11(2):203-6. DM6PZ45 RU https://pubmed.ncbi.nlm.nih.gov/11206459 DMKDZH4 DI DMKDZH4 DMKDZH4 DN AcAsp-Glu-Leu-Glu-Cha-Cys DMKDZH4 MI TTWXB3E DMKDZH4 MN Hepatitis C virus NS3 helicase (HCV NS3) DMKDZH4 MT DTT DMKDZH4 MA Inhibitor DMKDZH4 RN Inhibition of hepatitis C virus NS3 protease activity by product-based peptides is dependent on helicase domain. Bioorg Med Chem Lett. 2001 Jan 22;11(2):203-6. DMKDZH4 RU https://pubmed.ncbi.nlm.nih.gov/11206459 DMOMI91 DI DMOMI91 DMOMI91 DN AcAsp-Glu-Met-Glu-Cha-Cys DMOMI91 MI TTWXB3E DMOMI91 MN Hepatitis C virus NS3 helicase (HCV NS3) DMOMI91 MT DTT DMOMI91 MA Inhibitor DMOMI91 RN Inhibition of hepatitis C virus NS3 protease activity by product-based peptides is dependent on helicase domain. Bioorg Med Chem Lett. 2001 Jan 22;11(2):203-6. DMOMI91 RU https://pubmed.ncbi.nlm.nih.gov/11206459 DMIVFZE DI DMIVFZE DMIVFZE DN AcAsp-Glu-Met-Glu-Glu-Cys DMIVFZE MI TTWXB3E DMIVFZE MN Hepatitis C virus NS3 helicase (HCV NS3) DMIVFZE MT DTT DMIVFZE MA Inhibitor DMIVFZE RN Control of hepatitis C: a medicinal chemistry perspective. J Med Chem. 2005 Jan 13;48(1):1-20. DMIVFZE RU https://pubmed.ncbi.nlm.nih.gov/15633995 DMBGHX7 DI DMBGHX7 DMBGHX7 DN AcAsp-Glu-Met-Glu-Nal-Cyse DMBGHX7 MI TTWXB3E DMBGHX7 MN Hepatitis C virus NS3 helicase (HCV NS3) DMBGHX7 MT DTT DMBGHX7 MA Inhibitor DMBGHX7 RN Inhibition of hepatitis C virus NS3 protease activity by product-based peptides is dependent on helicase domain. Bioorg Med Chem Lett. 2001 Jan 22;11(2):203-6. DMBGHX7 RU https://pubmed.ncbi.nlm.nih.gov/11206459 DM4KQUS DI DM4KQUS DM4KQUS DN Ac-Asp-Glu-Val-Asp-CHO DM4KQUS MI TTPF2QI DM4KQUS MN Caspase-3 (CASP3) DM4KQUS MT DTT DM4KQUS MA Inhibitor DM4KQUS RN Design and synthesis of a potent and selective peptidomimetic inhibitor of caspase-3. J Med Chem. 2004 Dec 16;47(26):6455-8. DM4KQUS RU https://pubmed.ncbi.nlm.nih.gov/15588079 DM1KDJV DI DM1KDJV DM1KDJV DN Ac-bhg-F-N-Y-Y-W DM1KDJV MI TTKRD0G DM1KDJV MN Endothelin A receptor (EDNRA) DM1KDJV MT DTT DM1KDJV MA Inhibitor DM1KDJV RN Res-701-1, synthesis and a reevaluation of its effects on the endothelin receptors, Bioorg. Med. Chem. Lett. 5(6):621-626 (1995). DM1KDJV RU http://www.sciencedirect.com/science/article/pii/0960894X95000847 DM1KDJV DI DM1KDJV DM1KDJV DN Ac-bhg-F-N-Y-Y-W DM1KDJV MI TT3ZTGU DM1KDJV MN Endothelin B receptor (EDNRB) DM1KDJV MT DTT DM1KDJV MA Inhibitor DM1KDJV RN Res-701-1, synthesis and a reevaluation of its effects on the endothelin receptors, Bioorg. Med. Chem. Lett. 5(6):621-626 (1995). DM1KDJV RU http://www.sciencedirect.com/science/article/pii/0960894X95000847 DMSE29N DI DMSE29N DMSE29N DN Ac-Bth-Thr(PO3H2)-Pip-Nal-Gln-NH2 DMSE29N MI TTJNTSI DMSE29N MN Rotamase Pin1 (PIN1) DMSE29N MT DTT DMSE29N MA Inhibitor DMSE29N RN Nanomolar inhibitors of the peptidyl prolyl cis/trans isomerase Pin1 from combinatorial peptide libraries. J Med Chem. 2006 Apr 6;49(7):2147-50. DMSE29N RU https://pubmed.ncbi.nlm.nih.gov/16570909 DMH0SQC DI DMH0SQC DMH0SQC DN Ac-Cys-Ile-cyclo[Phe-Lys]-Tyr-Tyr DMH0SQC MI TT6PKBN DMH0SQC MN Proto-oncogene c-Src (SRC) DMH0SQC MT DTT DMH0SQC MA Inhibitor DMH0SQC RN Synthesis and structure-activity relationships of linear and conformationally constrained peptide analogues of CIYKYY as Src tyrosine kinase inhibi... J Med Chem. 2006 Jun 1;49(11):3395-401. DMH0SQC RU https://pubmed.ncbi.nlm.nih.gov/16722659 DMG19LW DI DMG19LW DMG19LW DN Ac-Cys-Ile-Phe(4-NO2)-Lys-Phe(4-NO2)-Tyr DMG19LW MI TT6PKBN DMG19LW MN Proto-oncogene c-Src (SRC) DMG19LW MT DTT DMG19LW MA Inhibitor DMG19LW RN Synthesis and structure-activity relationships of linear and conformationally constrained peptide analogues of CIYKYY as Src tyrosine kinase inhibi... J Med Chem. 2006 Jun 1;49(11):3395-401. DMG19LW RU https://pubmed.ncbi.nlm.nih.gov/16722659 DMORPDV DI DMORPDV DMORPDV DN Ac-Cys-Ile-Phe(4-NO2)-Lys-Tyr-Phe(4-NO2) DMORPDV MI TT6PKBN DMORPDV MN Proto-oncogene c-Src (SRC) DMORPDV MT DTT DMORPDV MA Inhibitor DMORPDV RN Synthesis and structure-activity relationships of linear and conformationally constrained peptide analogues of CIYKYY as Src tyrosine kinase inhibi... J Med Chem. 2006 Jun 1;49(11):3395-401. DMORPDV RU https://pubmed.ncbi.nlm.nih.gov/16722659 DMK7YIG DI DMK7YIG DMK7YIG DN Ac-Cys-Ile-Phe(4-NO2)-Lys-Tyr-Tyr DMK7YIG MI TT6PKBN DMK7YIG MN Proto-oncogene c-Src (SRC) DMK7YIG MT DTT DMK7YIG MA Inhibitor DMK7YIG RN Synthesis and structure-activity relationships of linear and conformationally constrained peptide analogues of CIYKYY as Src tyrosine kinase inhibi... J Med Chem. 2006 Jun 1;49(11):3395-401. DMK7YIG RU https://pubmed.ncbi.nlm.nih.gov/16722659 DMUWI2F DI DMUWI2F DMUWI2F DN Ac-Cys-Ile-Tyr-Lys-Phe(4-Cl)-Tyr DMUWI2F MI TT6PKBN DMUWI2F MN Proto-oncogene c-Src (SRC) DMUWI2F MT DTT DMUWI2F MA Inhibitor DMUWI2F RN Synthesis and structure-activity relationships of linear and conformationally constrained peptide analogues of CIYKYY as Src tyrosine kinase inhibi... J Med Chem. 2006 Jun 1;49(11):3395-401. DMUWI2F RU https://pubmed.ncbi.nlm.nih.gov/16722659 DMNW7GR DI DMNW7GR DMNW7GR DN Ac-Cys-Ile-Tyr-Lys-Phe(4-CN)-Tyr DMNW7GR MI TT6PKBN DMNW7GR MN Proto-oncogene c-Src (SRC) DMNW7GR MT DTT DMNW7GR MA Inhibitor DMNW7GR RN Synthesis and structure-activity relationships of linear and conformationally constrained peptide analogues of CIYKYY as Src tyrosine kinase inhibi... J Med Chem. 2006 Jun 1;49(11):3395-401. DMNW7GR RU https://pubmed.ncbi.nlm.nih.gov/16722659 DMO4MYI DI DMO4MYI DMO4MYI DN Ac-Cys-Ile-Tyr-Lys-Phe(4-I)-Tyr DMO4MYI MI TT6PKBN DMO4MYI MN Proto-oncogene c-Src (SRC) DMO4MYI MT DTT DMO4MYI MA Inhibitor DMO4MYI RN Synthesis and structure-activity relationships of linear and conformationally constrained peptide analogues of CIYKYY as Src tyrosine kinase inhibi... J Med Chem. 2006 Jun 1;49(11):3395-401. DMO4MYI RU https://pubmed.ncbi.nlm.nih.gov/16722659 DME4FZD DI DME4FZD DME4FZD DN Ac-Cys-Ile-Tyr-Lys-Phe(4-N3)-Tyr DME4FZD MI TT6PKBN DME4FZD MN Proto-oncogene c-Src (SRC) DME4FZD MT DTT DME4FZD MA Inhibitor DME4FZD RN Synthesis and structure-activity relationships of linear and conformationally constrained peptide analogues of CIYKYY as Src tyrosine kinase inhibi... J Med Chem. 2006 Jun 1;49(11):3395-401. DME4FZD RU https://pubmed.ncbi.nlm.nih.gov/16722659 DM856JM DI DM856JM DM856JM DN Ac-Cys-Ile-Tyr-Lys-Phe(4-NO2)-Phe(4-NO2) DM856JM MI TT6PKBN DM856JM MN Proto-oncogene c-Src (SRC) DM856JM MT DTT DM856JM MA Inhibitor DM856JM RN Synthesis and structure-activity relationships of linear and conformationally constrained peptide analogues of CIYKYY as Src tyrosine kinase inhibi... J Med Chem. 2006 Jun 1;49(11):3395-401. DM856JM RU https://pubmed.ncbi.nlm.nih.gov/16722659 DMU2PT1 DI DMU2PT1 DMU2PT1 DN Ac-Cys-Ile-Tyr-Lys-Phe(4-NO2)-Tyr-Phe DMU2PT1 MI TT6PKBN DMU2PT1 MN Proto-oncogene c-Src (SRC) DMU2PT1 MT DTT DMU2PT1 MA Inhibitor DMU2PT1 RN Synthesis and structure-activity relationships of linear and conformationally constrained peptide analogues of CIYKYY as Src tyrosine kinase inhibi... J Med Chem. 2006 Jun 1;49(11):3395-401. DMU2PT1 RU https://pubmed.ncbi.nlm.nih.gov/16722659 DM4MP69 DI DM4MP69 DM4MP69 DN Ac-Cys-Ile-Tyr-Lys-Tyr-Phe(4-NO2) DM4MP69 MI TT6PKBN DM4MP69 MN Proto-oncogene c-Src (SRC) DM4MP69 MT DTT DM4MP69 MA Inhibitor DM4MP69 RN Synthesis and structure-activity relationships of linear and conformationally constrained peptide analogues of CIYKYY as Src tyrosine kinase inhibi... J Med Chem. 2006 Jun 1;49(11):3395-401. DM4MP69 RU https://pubmed.ncbi.nlm.nih.gov/16722659 DMW02H7 DI DMW02H7 DMW02H7 DN Ac-DEVD-CHO DMW02H7 MI TTZY5KP DMW02H7 MN Caspase (CASP) DMW02H7 MT DTT DMW02H7 MA Inhibitor DMW02H7 RN Synthesis and evaluation of vinyl sulfones as caspase-3 inhibitors. A structure-activity study. Eur J Med Chem. 2010 Sep;45(9):3858-63. DMW02H7 RU https://pubmed.ncbi.nlm.nih.gov/20541849 DMW02H7 DI DMW02H7 DMW02H7 DN Ac-DEVD-CHO DMW02H7 MI TTPF2QI DMW02H7 MN Caspase-3 (CASP3) DMW02H7 MT DTT DMW02H7 MA Inhibitor DMW02H7 RN Synthesis and evaluation of vinyl sulfones as caspase-3 inhibitors. A structure-activity study. Eur J Med Chem. 2010 Sep;45(9):3858-63. DMW02H7 RU https://pubmed.ncbi.nlm.nih.gov/20541849 DMKDEWH DI DMKDEWH DMKDEWH DN AcDif-Glu-Cha-Cys DMKDEWH MI TTWXB3E DMKDEWH MN Hepatitis C virus NS3 helicase (HCV NS3) DMKDEWH MT DTT DMKDEWH MA Inhibitor DMKDEWH RN Inhibition of hepatitis C virus NS3 protease activity by product-based peptides is dependent on helicase domain. Bioorg Med Chem Lett. 2001 Jan 22;11(2):203-6. DMKDEWH RU https://pubmed.ncbi.nlm.nih.gov/11206459 DM1DWCP DI DM1DWCP DM1DWCP DN AcDif-Ile-Cha-Cys DM1DWCP MI TTWXB3E DM1DWCP MN Hepatitis C virus NS3 helicase (HCV NS3) DM1DWCP MT DTT DM1DWCP MA Inhibitor DM1DWCP RN Inhibition of hepatitis C virus NS3 protease activity by product-based peptides is dependent on helicase domain. Bioorg Med Chem Lett. 2001 Jan 22;11(2):203-6. DM1DWCP RU https://pubmed.ncbi.nlm.nih.gov/11206459 DMPMH7Z DI DMPMH7Z DMPMH7Z DN ACDPP DMPMH7Z MI TTHS256 DMPMH7Z MN Metabotropic glutamate receptor 5 (mGluR5) DMPMH7Z MT DTT DMPMH7Z MA Antagonist DMPMH7Z RN Dipyridyl amides: potent metabotropic glutamate subtype 5 (mGlu5) receptor antagonists. Bioorg Med Chem Lett. 2005 Feb 15;15(4):1197-200. DMPMH7Z RU https://pubmed.ncbi.nlm.nih.gov/15686941 DMVDH4I DI DMVDH4I DMVDH4I DN Ac-D-pro-L-Phe-D-trp-L-Phe-NH2 DMVDH4I MI TTKWM86 DMVDH4I MN Opioid receptor mu (MOP) DMVDH4I MT DTT DMVDH4I MA Inhibitor DMVDH4I RN Nascent structure-activity relationship study of a diastereomeric series of kappa opioid receptor antagonists derived from CJ-15,208. Bioorg Med Chem Lett. 2009 Jul 1;19(13):3647-50. DMVDH4I RU https://pubmed.ncbi.nlm.nih.gov/19464172 DM7XY41 DI DM7XY41 DM7XY41 DN Ac-dR[CEHdFRWC]-NH2 DM7XY41 MI TT0MV2T DM7XY41 MN Melanocortin receptor 1 (MC1R) DM7XY41 MT DTT DM7XY41 MA Inhibitor DM7XY41 RN Discovery of a beta-MSH-derived MC-4R selective agonist. J Med Chem. 2005 May 5;48(9):3095-8. DM7XY41 RU https://pubmed.ncbi.nlm.nih.gov/15857110 DM7XY41 DI DM7XY41 DM7XY41 DN Ac-dR[CEHdFRWC]-NH2 DM7XY41 MI TTNI91K DM7XY41 MN Melanocortin receptor 3 (MC3R) DM7XY41 MT DTT DM7XY41 MA Inhibitor DM7XY41 RN Discovery of a beta-MSH-derived MC-4R selective agonist. J Med Chem. 2005 May 5;48(9):3095-8. DM7XY41 RU https://pubmed.ncbi.nlm.nih.gov/15857110 DM7XY41 DI DM7XY41 DM7XY41 DN Ac-dR[CEHdFRWC]-NH2 DM7XY41 MI TTD0CIQ DM7XY41 MN Melanocortin receptor 4 (MC4R) DM7XY41 MT DTT DM7XY41 MA Inhibitor DM7XY41 RN Discovery of a beta-MSH-derived MC-4R selective agonist. J Med Chem. 2005 May 5;48(9):3095-8. DM7XY41 RU https://pubmed.ncbi.nlm.nih.gov/15857110 DM9MDBO DI DM9MDBO DM9MDBO DN AcDRGDS DM9MDBO MI TTT1R2L DM9MDBO MN Integrin alpha-V (ITGAV) DM9MDBO MT DTT DM9MDBO MA Inhibitor DM9MDBO RN Inhibition of cancer cell adhesion by heterochiral Pro-containing RGD mimetics. Bioorg Med Chem Lett. 2007 Apr 15;17(8):2329-33. DM9MDBO RU https://pubmed.ncbi.nlm.nih.gov/17289386 DM9MDBO DI DM9MDBO DM9MDBO DN AcDRGDS DM9MDBO MI TTJA1ZO DM9MDBO MN ITGB3 messenger RNA (ITGB3 mRNA) DM9MDBO MT DTT DM9MDBO MA Inhibitor DM9MDBO RN Inhibition of cancer cell adhesion by heterochiral Pro-containing RGD mimetics. Bioorg Med Chem Lett. 2007 Apr 15;17(8):2329-33. DM9MDBO RU https://pubmed.ncbi.nlm.nih.gov/17289386 DMOJGF3 DI DMOJGF3 DMOJGF3 DN ACE-435 DMOJGF3 MI TTP4520 DMOJGF3 MN TGF-beta receptor type I (TGFBR1) DMOJGF3 MT DTT DMOJGF3 MA Inhibitor DMOJGF3 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1788). DMOJGF3 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1788 DMWX3HT DI DMWX3HT DMWX3HT DN ACEA DMWX3HT MI TT6OEDT DMWX3HT MN Cannabinoid receptor 1 (CB1) DMWX3HT MT DTT DMWX3HT MA Agonist DMWX3HT RN Synthesis and characterization of potent and selective agonists of the neuronal cannabinoid receptor (CB1). J Pharmacol Exp Ther. 1999 Jun;289(3):1427-33. DMWX3HT RU https://pubmed.ncbi.nlm.nih.gov/10336536 DMVTSM8 DI DMVTSM8 DMVTSM8 DN Acefylline DMVTSM8 MI DEJGDUW DMVTSM8 MN Cytochrome P450 1A2 (CYP1A2) DMVTSM8 MT DME DMVTSM8 MA Metabolism DMVTSM8 RN PharmGKB summary: caffeine pathway. Pharmacogenet Genomics. 2012 May;22(5):389-95. DMVTSM8 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=22293536 DMU9O7K DI DMU9O7K DMU9O7K DN Acenanthrene-9,10-dione DMU9O7K MI TTMF541 DMU9O7K MN Liver carboxylesterase (CES1) DMU9O7K MT DTT DMU9O7K MA Inhibitor DMU9O7K RN Planarity and constraint of the carbonyl groups in 1,2-diones are determinants for selective inhibition of human carboxylesterase 1. J Med Chem. 2007 Nov 15;50(23):5727-34. DMU9O7K RU https://pubmed.ncbi.nlm.nih.gov/17941623 DMT3QYZ DI DMT3QYZ DMT3QYZ DN Acenaphthenol DMT3QYZ MI DEGQTXO DMT3QYZ MN Aldo-keto reductase 1C3 (AKR1C3) DMT3QYZ MT DME DMT3QYZ MA Metabolism DMT3QYZ RN Expression and characterization of four recombinant human dihydrodiol dehydrogenase isoforms: oxidation of trans-7, 8-dihydroxy-7,8-dihydrobenzo[a]pyrene to the activated o-quinone metabolite benzo[a]pyrene-7,8-dione. Biochemistry. 1998 May 12;37(19):6781-90. DMT3QYZ RU https://www.ncbi.nlm.nih.gov/pubmed/?term=9578563 DMU3DMH DI DMU3DMH DMU3DMH DN ACENAPHTHOQUINONE DMU3DMH MI TTEB0GD DMU3DMH MN Cholinesterase (BCHE) DMU3DMH MT DTT DMU3DMH MA Inhibitor DMU3DMH RN Planarity and constraint of the carbonyl groups in 1,2-diones are determinants for selective inhibition of human carboxylesterase 1. J Med Chem. 2007 Nov 15;50(23):5727-34. DMU3DMH RU https://pubmed.ncbi.nlm.nih.gov/17941623 DMU3DMH DI DMU3DMH DMU3DMH DN ACENAPHTHOQUINONE DMU3DMH MI TTMF541 DMU3DMH MN Liver carboxylesterase (CES1) DMU3DMH MT DTT DMU3DMH MA Inhibitor DMU3DMH RN Planarity and constraint of the carbonyl groups in 1,2-diones are determinants for selective inhibition of human carboxylesterase 1. J Med Chem. 2007 Nov 15;50(23):5727-34. DMU3DMH RU https://pubmed.ncbi.nlm.nih.gov/17941623 DM4BWMO DI DM4BWMO DM4BWMO DN Acerogenin A DM4BWMO MI TT2UE56 DM4BWMO MN Sodium/glucose cotransporter 1 (SGLT1) DM4BWMO MT DTT DM4BWMO MA Inhibitor DM4BWMO RN Cyclic diarylheptanoids as Na+-glucose cotransporter (SGLT) inhibitors from Acer nikoense. Bioorg Med Chem Lett. 2010 Feb 1;20(3):1070-4. DM4BWMO RU https://pubmed.ncbi.nlm.nih.gov/20036535 DMVQ30P DI DMVQ30P DMVQ30P DN Acerogenin B DMVQ30P MI TTF8JAT DMVQ30P MN SLC5A2 messenger RNA (SLC5A2 mRNA) DMVQ30P MT DTT DMVQ30P MA Inhibitor DMVQ30P RN Cyclic diarylheptanoids as Na+-glucose cotransporter (SGLT) inhibitors from Acer nikoense. Bioorg Med Chem Lett. 2010 Feb 1;20(3):1070-4. DMVQ30P RU https://pubmed.ncbi.nlm.nih.gov/20036535 DMVQ30P DI DMVQ30P DMVQ30P DN Acerogenin B DMVQ30P MI TT2UE56 DMVQ30P MN Sodium/glucose cotransporter 1 (SGLT1) DMVQ30P MT DTT DMVQ30P MA Inhibitor DMVQ30P RN Cyclic diarylheptanoids as Na+-glucose cotransporter (SGLT) inhibitors from Acer nikoense. Bioorg Med Chem Lett. 2010 Feb 1;20(3):1070-4. DMVQ30P RU https://pubmed.ncbi.nlm.nih.gov/20036535 DMNETSX DI DMNETSX DMNETSX DN Acerogenin C DMNETSX MI TTF8JAT DMNETSX MN SLC5A2 messenger RNA (SLC5A2 mRNA) DMNETSX MT DTT DMNETSX MA Inhibitor DMNETSX RN Cyclic diarylheptanoids as Na+-glucose cotransporter (SGLT) inhibitors from Acer nikoense. Bioorg Med Chem Lett. 2010 Feb 1;20(3):1070-4. DMNETSX RU https://pubmed.ncbi.nlm.nih.gov/20036535 DMB2463 DI DMB2463 DMB2463 DN ACET DMB2463 MI TT0MYE2 DMB2463 MN Glutamate receptor ionotropic kainate 1 (GRIK1) DMB2463 MT DTT DMB2463 MA Antagonist DMB2463 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 450). DMB2463 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=450 DMJFKG4 DI DMJFKG4 DMJFKG4 DN Acetaldehyde DMJFKG4 MI DEM1HNL DMJFKG4 MN Alcohol dehydrogenase class-I gamma (ADH1C) DMJFKG4 MT DME DMJFKG4 MA Metabolism DMJFKG4 RN Oxidation of alcohols and reduction of aldehydes derived from methyl- and dimethylpyrenes by cDNA-expressed human alcohol dehydrogenases. Toxicology. 2008 Mar 12;245(1-2):65-75. DMJFKG4 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=18242813 DMJFKG4 DI DMJFKG4 DMJFKG4 DN Acetaldehyde DMJFKG4 MI DEOCWU3 DMJFKG4 MN Alcohol dehydrogenase class-II (ADH4) DMJFKG4 MT DME DMJFKG4 MA Metabolism DMJFKG4 RN Oxidation of alcohols and reduction of aldehydes derived from methyl- and dimethylpyrenes by cDNA-expressed human alcohol dehydrogenases. Toxicology. 2008 Mar 12;245(1-2):65-75. DMJFKG4 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=18242813 DMJFKG4 DI DMJFKG4 DMJFKG4 DN Acetaldehyde DMJFKG4 MI TTELV3W DMJFKG4 MN Transformation-sensitive protein p120 (TRPA1) DMJFKG4 MT DTT DMJFKG4 MA Activator DMJFKG4 RN Transient receptor potential A1 mediates acetaldehyde-evoked pain sensation. Eur J Neurosci. 2007 Nov;26(9):2516-23. DMJFKG4 RU https://pubmed.ncbi.nlm.nih.gov/17970723 DMD08RH DI DMD08RH DMD08RH DN Acetate Ion DMD08RH MI TTL69WB DMD08RH MN Angiotensin-converting enzyme (ACE) DMD08RH MT DTT DMD08RH MA Inhibitor DMD08RH RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMD08RH RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMD08RH DI DMD08RH DMD08RH DN Acetate Ion DMD08RH MI TTY8KJS DMD08RH MN Bacterial Deoxyuridine triphosphate nucleotidohydrolase (Bact dut) DMD08RH MT DTT DMD08RH MA Inhibitor DMD08RH RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMD08RH RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMD08RH DI DMD08RH DMD08RH DN Acetate Ion DMD08RH MI TTC67I0 DMD08RH MN Bacterial Glucosamine-6-phosphate synthase (Bact glmS) DMD08RH MT DTT DMD08RH MA Inhibitor DMD08RH RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMD08RH RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMD08RH DI DMD08RH DMD08RH DN Acetate Ion DMD08RH MI TT38ECI DMD08RH MN Bacterial Hydroxymethyl-dihydropterin pyrophosphokinase (Bact folK) DMD08RH MT DTT DMD08RH MA Inhibitor DMD08RH RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMD08RH RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMD08RH DI DMD08RH DMD08RH DN Acetate Ion DMD08RH MI TTV3NH6 DMD08RH MN Calmodulin (CALM) DMD08RH MT DTT DMD08RH MA Inhibitor DMD08RH RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMD08RH RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMD08RH DI DMD08RH DMD08RH DN Acetate Ion DMD08RH MI TT915ZD DMD08RH MN Candida Mannose-6-phosphate isomerase (Candi PMI1) DMD08RH MT DTT DMD08RH MA Inhibitor DMD08RH RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMD08RH RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMD08RH DI DMD08RH DMD08RH DN Acetate Ion DMD08RH MI TTANPDJ DMD08RH MN Carbonic anhydrase II (CA-II) DMD08RH MT DTT DMD08RH MA Inhibitor DMD08RH RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMD08RH RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMD08RH DI DMD08RH DMD08RH DN Acetate Ion DMD08RH MI TT5ZWB6 DMD08RH MN Dihydrodiol dehydrogenase type I (AKR1C3) DMD08RH MT DTT DMD08RH MA Inhibitor DMD08RH RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMD08RH RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMD08RH DI DMD08RH DMD08RH DN Acetate Ion DMD08RH MI TTOM3J0 DMD08RH MN Estrogen receptor beta (ESR2) DMD08RH MT DTT DMD08RH MA Inhibitor DMD08RH RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMD08RH RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMD08RH DI DMD08RH DMD08RH DN Acetate Ion DMD08RH MI TTT2LD9 DMD08RH MN GABA transaminase (ABAT) DMD08RH MT DTT DMD08RH MA Inhibitor DMD08RH RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMD08RH RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMD08RH DI DMD08RH DMD08RH DN Acetate Ion DMD08RH MI TT8DSFC DMD08RH MN Hydroxyphenylpyruvate dioxygenase (HPD) DMD08RH MT DTT DMD08RH MA Inhibitor DMD08RH RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMD08RH RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMD08RH DI DMD08RH DMD08RH DN Acetate Ion DMD08RH MI TTXZEAJ DMD08RH MN Leukotriene A-4 hydrolase (LTA4H) DMD08RH MT DTT DMD08RH MA Inhibitor DMD08RH RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMD08RH RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMD08RH DI DMD08RH DMD08RH DN Acetate Ion DMD08RH MI TTXZ0KQ DMD08RH MN Matrix metalloproteinase-12 (MMP-12) DMD08RH MT DTT DMD08RH MA Inhibitor DMD08RH RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMD08RH RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMD08RH DI DMD08RH DMD08RH DN Acetate Ion DMD08RH MI TT6TMZU DMD08RH MN Mycobacterium Biosynthetic alanine racemase (MycB alr) DMD08RH MT DTT DMD08RH MA Inhibitor DMD08RH RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMD08RH RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMD08RH DI DMD08RH DMD08RH DN Acetate Ion DMD08RH MI TT5B8AX DMD08RH MN Mycobacterium Thymidine monophosphate kinase (MycB tmk) DMD08RH MT DTT DMD08RH MA Inhibitor DMD08RH RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMD08RH RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMD08RH DI DMD08RH DMD08RH DN Acetate Ion DMD08RH MI TTZUFI5 DMD08RH MN Nitric-oxide synthase brain (NOS1) DMD08RH MT DTT DMD08RH MA Inhibitor DMD08RH RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMD08RH RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMD08RH DI DMD08RH DMD08RH DN Acetate Ion DMD08RH MI TTCM4B3 DMD08RH MN Nitric-oxide synthase endothelial (NOS3) DMD08RH MT DTT DMD08RH MA Inhibitor DMD08RH RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMD08RH RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMD08RH DI DMD08RH DMD08RH DN Acetate Ion DMD08RH MI TT3NKIB DMD08RH MN Pancreatic elastase 1 (CELA1) DMD08RH MT DTT DMD08RH MA Inhibitor DMD08RH RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMD08RH RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMD08RH DI DMD08RH DMD08RH DN Acetate Ion DMD08RH MI TT9V5JH DMD08RH MN Phospholipase A2 (PLA2G1B) DMD08RH MT DTT DMD08RH MA Inhibitor DMD08RH RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMD08RH RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMD08RH DI DMD08RH DMD08RH DN Acetate Ion DMD08RH MI TT3PQ2Y DMD08RH MN Plasmodium Dihydroorotate dehydrogenase (Malaria DHOdehase) DMD08RH MT DTT DMD08RH MA Inhibitor DMD08RH RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMD08RH RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMD08RH DI DMD08RH DMD08RH DN Acetate Ion DMD08RH MI TTBL49X DMD08RH MN Plasmodium Hypoxanthine-guanine phosphoribosyltransferase (Malaria LACZ) DMD08RH MT DTT DMD08RH MA Inhibitor DMD08RH RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMD08RH RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMD08RH DI DMD08RH DMD08RH DN Acetate Ion DMD08RH MI TTELIN2 DMD08RH MN PTPN1 messenger RNA (PTPN1 mRNA) DMD08RH MT DTT DMD08RH MA Inhibitor DMD08RH RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMD08RH RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMD08RH DI DMD08RH DMD08RH DN Acetate Ion DMD08RH MI TTHI19T DMD08RH MN Staphylococcus Beta-lactamase (Stap-coc blaZ) DMD08RH MT DTT DMD08RH MA Inhibitor DMD08RH RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMD08RH RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMD08RH DI DMD08RH DMD08RH DN Acetate Ion DMD08RH MI TTN6GE9 DMD08RH MN Staphylococcus D-amino acid aminotransferase (Stap-coc dat) DMD08RH MT DTT DMD08RH MA Inhibitor DMD08RH RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMD08RH RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMD08RH DI DMD08RH DMD08RH DN Acetate Ion DMD08RH MI TT6RVLG DMD08RH MN Superoxide dismutase Cu-Zn (SOD Cu-Zn) DMD08RH MT DTT DMD08RH MA Inhibitor DMD08RH RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMD08RH RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMD08RH DI DMD08RH DMD08RH DN Acetate Ion DMD08RH MI TTZJ5U9 DMD08RH MN Thioredoxin (TXN) DMD08RH MT DTT DMD08RH MA Inhibitor DMD08RH RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMD08RH RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMBP5L4 DI DMBP5L4 DMBP5L4 DN Acetic acid 2,6-diisopropyl-phenyl ester DMBP5L4 MI TTNJYV2 DMBP5L4 MN Gamma-aminobutyric acid receptor (GAR) DMBP5L4 MT DTT DMBP5L4 MA Inhibitor DMBP5L4 RN Propofol analogues. Synthesis, relationships between structure and affinity at GABAA receptor in rat brain, and differential electrophysiological p... J Med Chem. 1998 May 21;41(11):1846-54. DMBP5L4 RU https://pubmed.ncbi.nlm.nih.gov/9599235 DM97DJL DI DM97DJL DM97DJL DN Acetic acid 2-hept-2-ynylsulfanyl-phenyl ester DM97DJL MI TT8NGED DM97DJL MN Prostaglandin G/H synthase 1 (COX-1) DM97DJL MT DTT DM97DJL MA Inhibitor DM97DJL RN Covalent modification of cyclooxygenase-2 (COX-2) by 2-acetoxyphenyl alkyl sulfides, a new class of selective COX-2 inactivators. J Med Chem. 1998 Nov 19;41(24):4800-18. DM97DJL RU https://pubmed.ncbi.nlm.nih.gov/9822550 DMD89A1 DI DMD89A1 DMD89A1 DN Acetic acid 2-hept-3-ynylsulfanyl-phenyl ester DMD89A1 MI TT8NGED DMD89A1 MN Prostaglandin G/H synthase 1 (COX-1) DMD89A1 MT DTT DMD89A1 MA Inhibitor DMD89A1 RN Covalent modification of cyclooxygenase-2 (COX-2) by 2-acetoxyphenyl alkyl sulfides, a new class of selective COX-2 inactivators. J Med Chem. 1998 Nov 19;41(24):4800-18. DMD89A1 RU https://pubmed.ncbi.nlm.nih.gov/9822550 DM50BTA DI DM50BTA DM50BTA DN Acetic acid 2-heptylselanyl-phenyl ester DM50BTA MI TT8NGED DM50BTA MN Prostaglandin G/H synthase 1 (COX-1) DM50BTA MT DTT DM50BTA MA Inhibitor DM50BTA RN Covalent modification of cyclooxygenase-2 (COX-2) by 2-acetoxyphenyl alkyl sulfides, a new class of selective COX-2 inactivators. J Med Chem. 1998 Nov 19;41(24):4800-18. DM50BTA RU https://pubmed.ncbi.nlm.nih.gov/9822550 DMLPRIG DI DMLPRIG DMLPRIG DN Acetic acid 2-heptylsulfanyl-phenyl ester DMLPRIG MI TT8NGED DMLPRIG MN Prostaglandin G/H synthase 1 (COX-1) DMLPRIG MT DTT DMLPRIG MA Inhibitor DMLPRIG RN Covalent modification of cyclooxygenase-2 (COX-2) by 2-acetoxyphenyl alkyl sulfides, a new class of selective COX-2 inactivators. J Med Chem. 1998 Nov 19;41(24):4800-18. DMLPRIG RU https://pubmed.ncbi.nlm.nih.gov/9822550 DMFQE1C DI DMFQE1C DMFQE1C DN Acetic acid 2-hex-2-ynylsulfanyl-phenyl ester DMFQE1C MI TT8NGED DMFQE1C MN Prostaglandin G/H synthase 1 (COX-1) DMFQE1C MT DTT DMFQE1C MA Inhibitor DMFQE1C RN Covalent modification of cyclooxygenase-2 (COX-2) by 2-acetoxyphenyl alkyl sulfides, a new class of selective COX-2 inactivators. J Med Chem. 1998 Nov 19;41(24):4800-18. DMFQE1C RU https://pubmed.ncbi.nlm.nih.gov/9822550 DMAKNUH DI DMAKNUH DMAKNUH DN Acetic acid 2-hexylsulfanyl-phenyl ester DMAKNUH MI TT8NGED DMAKNUH MN Prostaglandin G/H synthase 1 (COX-1) DMAKNUH MT DTT DMAKNUH MA Inhibitor DMAKNUH RN Covalent modification of cyclooxygenase-2 (COX-2) by 2-acetoxyphenyl alkyl sulfides, a new class of selective COX-2 inactivators. J Med Chem. 1998 Nov 19;41(24):4800-18. DMAKNUH RU https://pubmed.ncbi.nlm.nih.gov/9822550 DMFKRIH DI DMFKRIH DMFKRIH DN Acetic acid 2-pentylsulfanyl-phenyl ester DMFKRIH MI TT8NGED DMFKRIH MN Prostaglandin G/H synthase 1 (COX-1) DMFKRIH MT DTT DMFKRIH MA Inhibitor DMFKRIH RN Covalent modification of cyclooxygenase-2 (COX-2) by 2-acetoxyphenyl alkyl sulfides, a new class of selective COX-2 inactivators. J Med Chem. 1998 Nov 19;41(24):4800-18. DMFKRIH RU https://pubmed.ncbi.nlm.nih.gov/9822550 DMUYKIE DI DMUYKIE DMUYKIE DN Acetic acid 2-phenyl-5-propyl-thiazol-4-yl ester DMUYKIE MI TT2J34L DMUYKIE MN Arachidonate 5-lipoxygenase (5-LOX) DMUYKIE MT DTT DMUYKIE MA Inhibitor DMUYKIE RN 4-hydroxythiazole inhibitors of 5-lipoxygenase. J Med Chem. 1991 Jul;34(7):2158-65. DMUYKIE RU https://pubmed.ncbi.nlm.nih.gov/2066989 DM95QEA DI DM95QEA DM95QEA DN Acetic acid 5-butyl-2-phenyl-thiazol-4-yl ester DM95QEA MI TT2J34L DM95QEA MN Arachidonate 5-lipoxygenase (5-LOX) DM95QEA MT DTT DM95QEA MA Inhibitor DM95QEA RN 4-hydroxythiazole inhibitors of 5-lipoxygenase. J Med Chem. 1991 Jul;34(7):2158-65. DM95QEA RU https://pubmed.ncbi.nlm.nih.gov/2066989 DMVEH40 DI DMVEH40 DMVEH40 DN Acetic acid 8-aza-bicyclo[3.2.1]oct-6-yl ester DMVEH40 MI TTZ9SOR DMVEH40 MN Muscarinic acetylcholine receptor M1 (CHRM1) DMVEH40 MT DTT DMVEH40 MA Inhibitor DMVEH40 RN 6beta-Acetoxynortropane: a potent muscarinic agonist with apparent selectivity toward M2-receptors. J Med Chem. 1998 Jun 4;41(12):2047-55. DMVEH40 RU https://pubmed.ncbi.nlm.nih.gov/9622546 DMVEH40 DI DMVEH40 DMVEH40 DN Acetic acid 8-aza-bicyclo[3.2.1]oct-6-yl ester DMVEH40 MI TTYEG6Q DMVEH40 MN Muscarinic acetylcholine receptor M2 (CHRM2) DMVEH40 MT DTT DMVEH40 MA Inhibitor DMVEH40 RN 6beta-Acetoxynortropane: a potent muscarinic agonist with apparent selectivity toward M2-receptors. J Med Chem. 1998 Jun 4;41(12):2047-55. DMVEH40 RU https://pubmed.ncbi.nlm.nih.gov/9622546 DMVEH40 DI DMVEH40 DMVEH40 DN Acetic acid 8-aza-bicyclo[3.2.1]oct-6-yl ester DMVEH40 MI TTQ13Z5 DMVEH40 MN Muscarinic acetylcholine receptor M3 (CHRM3) DMVEH40 MT DTT DMVEH40 MA Inhibitor DMVEH40 RN 6beta-Acetoxynortropane: a potent muscarinic agonist with apparent selectivity toward M2-receptors. J Med Chem. 1998 Jun 4;41(12):2047-55. DMVEH40 RU https://pubmed.ncbi.nlm.nih.gov/9622546 DMVEH40 DI DMVEH40 DMVEH40 DN Acetic acid 8-aza-bicyclo[3.2.1]oct-6-yl ester DMVEH40 MI TTQ3JTF DMVEH40 MN Muscarinic acetylcholine receptor M4 (CHRM4) DMVEH40 MT DTT DMVEH40 MA Inhibitor DMVEH40 RN 6beta-Acetoxynortropane: a potent muscarinic agonist with apparent selectivity toward M2-receptors. J Med Chem. 1998 Jun 4;41(12):2047-55. DMVEH40 RU https://pubmed.ncbi.nlm.nih.gov/9622546 DMVEH40 DI DMVEH40 DMVEH40 DN Acetic acid 8-aza-bicyclo[3.2.1]oct-6-yl ester DMVEH40 MI TTH18TF DMVEH40 MN Muscarinic acetylcholine receptor M5 (CHRM5) DMVEH40 MT DTT DMVEH40 MA Inhibitor DMVEH40 RN 6beta-Acyloxy(nor)tropanes: affinities for antagonist/agonist binding sites on transfected and native muscarinic receptors. J Med Chem. 2000 Jun 29;43(13):2514-22. DMVEH40 RU https://pubmed.ncbi.nlm.nih.gov/10891110 DMLTNHY DI DMLTNHY DMLTNHY DN Acetic Acid Salicyloyl-Amino-Ester DMLTNHY MI TT8NGED DMLTNHY MN Prostaglandin G/H synthase 1 (COX-1) DMLTNHY MT DTT DMLTNHY MA Inhibitor DMLTNHY RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DMLTNHY RU https://pubmed.ncbi.nlm.nih.gov/10592235 DM3HYU8 DI DM3HYU8 DM3HYU8 DN Acetoacetyl-Coenzyme A DM3HYU8 MI TTS0EZJ DM3HYU8 MN Hydroxymethylglutaryl-CoA synthase 2 (HMGCS2) DM3HYU8 MT DTT DM3HYU8 MA Inhibitor DM3HYU8 RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DM3HYU8 RU https://pubmed.ncbi.nlm.nih.gov/17139284 DM3HYU8 DI DM3HYU8 DM3HYU8 DN Acetoacetyl-Coenzyme A DM3HYU8 MI TT8HWCD DM3HYU8 MN Staphylococcus DHNA-CoA synthase (Stap-coc menB) DM3HYU8 MT DTT DM3HYU8 MA Inhibitor DM3HYU8 RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DM3HYU8 RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMH65Q8 DI DMH65Q8 DMH65Q8 DN Acetyl Coa DMH65Q8 MI DEA742Z DMH65Q8 MN Cysteinyl-conjugate N-acetyltransferase (NAT8) DMH65Q8 MT DME DMH65Q8 MA Metabolism DMH65Q8 RN Molecular identification of NAT8 as the enzyme that acetylates cysteine S-conjugates to mercapturic acids. J Biol Chem. 2010 Jun 11;285(24):18888-98. DMH65Q8 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=20392701 DMUH4N7 DI DMUH4N7 DMUH4N7 DN Acetyl ethylene DMUH4N7 MI DE8RYV5 DMUH4N7 MN NADPH:quinone reductase (CRYZ) DMUH4N7 MT DME DMUH4N7 MA Metabolism DMUH4N7 RN Kinetic and structural evidence of the alkenal/one reductase specificity of human crystallin. Cell Mol Life Sci. 2011 Mar;68(6):1065-77. DMUH4N7 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=20835842 DMFZJRN DI DMFZJRN DMFZJRN DN Acetyl-Ala-Ala-Pro-Ala-trifluromethane DMFZJRN MI TT3NKIB DMFZJRN MN Pancreatic elastase 1 (CELA1) DMFZJRN MT DTT DMFZJRN MA Inhibitor DMFZJRN RN Synthesis of peptidyl fluoromethyl ketones and peptidyl alpha-keto esters as inhibitors of porcine pancreatic elastase, human neutrophil elastase, ... J Med Chem. 1990 Jan;33(1):394-407. DMFZJRN RU https://pubmed.ncbi.nlm.nih.gov/2296031 DM1VE6S DI DM1VE6S DM1VE6S DN Acetyl-Ile-Glu-Thr-Asp-aldehyde DM1VE6S MI TT6SZNG DM1VE6S MN Caspase 8 messenger RNA (CASP8 mRNA) DM1VE6S MT DTT DM1VE6S MA Inhibitor DM1VE6S RN Synthesis and in vitro evaluation of sulfonamide isatin Michael acceptors as small molecule inhibitors of caspase-6. J Med Chem. 2009 Apr 23;52(8):2188-91. DM1VE6S RU https://pubmed.ncbi.nlm.nih.gov/19326941 DM1VE6S DI DM1VE6S DM1VE6S DN Acetyl-Ile-Glu-Thr-Asp-aldehyde DM1VE6S MI TTEVCT0 DM1VE6S MN Caspase-8 (CASP8) DM1VE6S MT DTT DM1VE6S MA Inhibitor DM1VE6S RN The atomic-resolution structure of human caspase-8, a key activator of apoptosis. Structure. 1999 Sep 15;7(9):1135-43. DM1VE6S RU https://pubmed.ncbi.nlm.nih.gov/10508785 DM74HGJ DI DM74HGJ DM74HGJ DN Acetyl-L-carnitine DM74HGJ MI DT3HUVD DM74HGJ MN Organic cation/carnitine transporter 2 (SLC22A5) DM74HGJ MT DTP DM74HGJ MA Substrate DM74HGJ RN Na(+)-dependent carnitine transport by organic cation transporter (OCTN2): its pharmacological and toxicological relevance. J Pharmacol Exp Ther. 1999 Nov;291(2):778-84. DM74HGJ RU http://www.ncbi.nlm.nih.gov/pubmed/10525100 DMGTPFY DI DMGTPFY DMGTPFY DN acetyl-podocarpic dimer DMGTPFY MI TTECBXN DMGTPFY MN Oxysterols receptor LXR-alpha (NR1H3) DMGTPFY MT DTT DMGTPFY MA Agonist DMGTPFY RN A potent synthetic LXR agonist is more effective than cholesterol loading at inducing ABCA1 mRNA and stimulating cholesterol efflux. J Biol Chem. 2002 Mar 22;277(12):10021-7. DMGTPFY RU https://pubmed.ncbi.nlm.nih.gov/11790770 DMGTPFY DI DMGTPFY DMGTPFY DN acetyl-podocarpic dimer DMGTPFY MI TTXA6PH DMGTPFY MN Oxysterols receptor LXR-beta (NR1H2) DMGTPFY MT DTT DMGTPFY MA Agonist DMGTPFY RN A potent synthetic LXR agonist is more effective than cholesterol loading at inducing ABCA1 mRNA and stimulating cholesterol efflux. J Biol Chem. 2002 Mar 22;277(12):10021-7. DMGTPFY RU https://pubmed.ncbi.nlm.nih.gov/11790770 DMN5Z0F DI DMN5Z0F DMN5Z0F DN Acetyl-Pro-Ala-Pro-Ala-trifluoro methane DMN5Z0F MI TT3NKIB DMN5Z0F MN Pancreatic elastase 1 (CELA1) DMN5Z0F MT DTT DMN5Z0F MA Inhibitor DMN5Z0F RN Synthesis of peptidyl fluoromethyl ketones and peptidyl alpha-keto esters as inhibitors of porcine pancreatic elastase, human neutrophil elastase, ... J Med Chem. 1990 Jan;33(1):394-407. DMN5Z0F RU https://pubmed.ncbi.nlm.nih.gov/2296031 DMG8P24 DI DMG8P24 DMG8P24 DN ACETYLSULFANILAMIDE DMG8P24 MI TTANPDJ DMG8P24 MN Carbonic anhydrase II (CA-II) DMG8P24 MT DTT DMG8P24 MA Inhibitor DMG8P24 RN Carbonic anhydrase inhibitors: inhibition of the tumor-associated isozymes IX and XII with a library of aromatic and heteroaromatic sulfonamides. Bioorg Med Chem Lett. 2005 Nov 1;15(21):4862-6. DMG8P24 RU https://pubmed.ncbi.nlm.nih.gov/16168653 DMG8P24 DI DMG8P24 DMG8P24 DN ACETYLSULFANILAMIDE DMG8P24 MI TT2LVK8 DMG8P24 MN Carbonic anhydrase IX (CA-IX) DMG8P24 MT DTT DMG8P24 MA Inhibitor DMG8P24 RN Carbonic anhydrase inhibitors: inhibition of the tumor-associated isozymes IX and XII with a library of aromatic and heteroaromatic sulfonamides. Bioorg Med Chem Lett. 2005 Nov 1;15(21):4862-6. DMG8P24 RU https://pubmed.ncbi.nlm.nih.gov/16168653 DMG8P24 DI DMG8P24 DMG8P24 DN ACETYLSULFANILAMIDE DMG8P24 MI TTSYM0R DMG8P24 MN Carbonic anhydrase XII (CA-XII) DMG8P24 MT DTT DMG8P24 MA Inhibitor DMG8P24 RN Carbonic anhydrase inhibitors: inhibition of the tumor-associated isozymes IX and XII with a library of aromatic and heteroaromatic sulfonamides. Bioorg Med Chem Lett. 2005 Nov 1;15(21):4862-6. DMG8P24 RU https://pubmed.ncbi.nlm.nih.gov/16168653 DM3XHIY DI DM3XHIY DM3XHIY DN Ac-FWKY-NH2 DM3XHIY MI TTW5UDX DM3XHIY MN Urotensin II receptor (UTS2R) DM3XHIY MT DTT DM3XHIY MA Inhibitor DM3XHIY RN Urotensin-II receptor modulators as potential drugs. J Med Chem. 2010 Apr 8;53(7):2695-708. DM3XHIY RU https://pubmed.ncbi.nlm.nih.gov/20043680 DMAI43O DI DMAI43O DMAI43O DN AcGlu-Asp-Val-Val-Leu-Cys-Iqc-Nle-Thr-TyrNH2 DMAI43O MI TTWXB3E DMAI43O MN Hepatitis C virus NS3 helicase (HCV NS3) DMAI43O MT DTT DMAI43O MA Inhibitor DMAI43O RN Control of hepatitis C: a medicinal chemistry perspective. J Med Chem. 2005 Jan 13;48(1):1-20. DMAI43O RU https://pubmed.ncbi.nlm.nih.gov/15633995 DM6T09B DI DM6T09B DM6T09B DN Ac-Glu-Cha-Cys DM6T09B MI TTWXB3E DM6T09B MN Hepatitis C virus NS3 helicase (HCV NS3) DM6T09B MT DTT DM6T09B MA Inhibitor DM6T09B RN Inhibition of hepatitis C virus NS3 protease activity by product-based peptides is dependent on helicase domain. Bioorg Med Chem Lett. 2001 Jan 22;11(2):203-6. DM6T09B RU https://pubmed.ncbi.nlm.nih.gov/11206459 DM0BV9I DI DM0BV9I DM0BV9I DN AcGlu-Dif-Glu-Cha-Cys DM0BV9I MI TTWXB3E DM0BV9I MN Hepatitis C virus NS3 helicase (HCV NS3) DM0BV9I MT DTT DM0BV9I MA Inhibitor DM0BV9I RN Inhibition of hepatitis C virus NS3 protease activity by product-based peptides is dependent on helicase domain. Bioorg Med Chem Lett. 2001 Jan 22;11(2):203-6. DM0BV9I RU https://pubmed.ncbi.nlm.nih.gov/11206459 DMK6HGI DI DMK6HGI DMK6HGI DN AcGlu-Dif-Ile-Cha-Cys DMK6HGI MI TTWXB3E DMK6HGI MN Hepatitis C virus NS3 helicase (HCV NS3) DMK6HGI MT DTT DMK6HGI MA Inhibitor DMK6HGI RN Inhibition of hepatitis C virus NS3 protease activity by product-based peptides is dependent on helicase domain. Bioorg Med Chem Lett. 2001 Jan 22;11(2):203-6. DMK6HGI RU https://pubmed.ncbi.nlm.nih.gov/11206459 DMMNQE3 DI DMMNQE3 DMMNQE3 DN ACH-702 DMMNQE3 MI TTE72ID DMMNQE3 MN Haemophilus influenzae DNA gyrase A (Hae-influ gyrA) DMMNQE3 MT DTT DMMNQE3 MA Inhibitor DMMNQE3 RN In vitro antituberculosis activities of ACH-702, a novel isothiazoloquinolone, against quinolone-susceptible and quinolone-resistant isolates. Antimicrob Agents Chemother. 2010 Aug;54(8):3478-80. DMMNQE3 RU https://pubmed.ncbi.nlm.nih.gov/20516287 DMUEBRN DI DMUEBRN DMUEBRN DN Ac-His-DNal(2)-Arg-Trp-NH2 DMUEBRN MI TTEOSZT DMUEBRN MN Melanocortin receptor (MCR) DMUEBRN MT DTT DMUEBRN MA Inhibitor DMUEBRN RN Melanocortin tetrapeptide Ac-His-DPhe-Arg-Trp-NH2 modified at the para position of the benzyl side chain (DPhe): importance for mouse melanocortin-... J Med Chem. 2008 Sep 25;51(18):5585-93. DMUEBRN RU https://pubmed.ncbi.nlm.nih.gov/18800761 DMR31Z9 DI DMR31Z9 DMR31Z9 DN Ac-His-DPhe(3,4-diCl)-Arg-Trp-NH2 DMR31Z9 MI TTEOSZT DMR31Z9 MN Melanocortin receptor (MCR) DMR31Z9 MT DTT DMR31Z9 MA Inhibitor DMR31Z9 RN Melanocortin tetrapeptide Ac-His-DPhe-Arg-Trp-NH2 modified at the para position of the benzyl side chain (DPhe): importance for mouse melanocortin-... J Med Chem. 2008 Sep 25;51(18):5585-93. DMR31Z9 RU https://pubmed.ncbi.nlm.nih.gov/18800761 DMXU5ZP DI DMXU5ZP DMXU5ZP DN Ac-His-DPhe(pBr)-Arg-Trp-NH2 DMXU5ZP MI TTEOSZT DMXU5ZP MN Melanocortin receptor (MCR) DMXU5ZP MT DTT DMXU5ZP MA Inhibitor DMXU5ZP RN Melanocortin tetrapeptide Ac-His-DPhe-Arg-Trp-NH2 modified at the para position of the benzyl side chain (DPhe): importance for mouse melanocortin-... J Med Chem. 2008 Sep 25;51(18):5585-93. DMXU5ZP RU https://pubmed.ncbi.nlm.nih.gov/18800761 DMTA6I5 DI DMTA6I5 DMTA6I5 DN Ac-His-DPhe(pCF3)-Arg-Trp-NH2 DMTA6I5 MI TTEOSZT DMTA6I5 MN Melanocortin receptor (MCR) DMTA6I5 MT DTT DMTA6I5 MA Inhibitor DMTA6I5 RN Melanocortin tetrapeptide Ac-His-DPhe-Arg-Trp-NH2 modified at the para position of the benzyl side chain (DPhe): importance for mouse melanocortin-... J Med Chem. 2008 Sep 25;51(18):5585-93. DMTA6I5 RU https://pubmed.ncbi.nlm.nih.gov/18800761 DM3GSPX DI DM3GSPX DM3GSPX DN Ac-His-DPhe(pI)-Arg-Trp-NH2 DM3GSPX MI TTEOSZT DM3GSPX MN Melanocortin receptor (MCR) DM3GSPX MT DTT DM3GSPX MA Inhibitor DM3GSPX RN Melanocortin tetrapeptide Ac-His-DPhe-Arg-Trp-NH2 modified at the para position of the benzyl side chain (DPhe): importance for mouse melanocortin-... J Med Chem. 2008 Sep 25;51(18):5585-93. DM3GSPX RU https://pubmed.ncbi.nlm.nih.gov/18800761 DMAQR29 DI DMAQR29 DMAQR29 DN Ac-His-D-Phe-Arg-2-Nal-NHCH3 DMAQR29 MI TT0MV2T DMAQR29 MN Melanocortin receptor 1 (MC1R) DMAQR29 MT DTT DMAQR29 MA Inhibitor DMAQR29 RN Design and synthesis of potent and selective 1,3,4-trisubstituted-2-oxopiperazine based melanocortin-4 receptor agonists. Bioorg Med Chem Lett. 2006 Sep 1;16(17):4668-73. DMAQR29 RU https://pubmed.ncbi.nlm.nih.gov/16766182 DMAQR29 DI DMAQR29 DMAQR29 DN Ac-His-D-Phe-Arg-2-Nal-NHCH3 DMAQR29 MI TTNI91K DMAQR29 MN Melanocortin receptor 3 (MC3R) DMAQR29 MT DTT DMAQR29 MA Inhibitor DMAQR29 RN Design and synthesis of potent and selective 1,3,4-trisubstituted-2-oxopiperazine based melanocortin-4 receptor agonists. Bioorg Med Chem Lett. 2006 Sep 1;16(17):4668-73. DMAQR29 RU https://pubmed.ncbi.nlm.nih.gov/16766182 DMAQR29 DI DMAQR29 DMAQR29 DN Ac-His-D-Phe-Arg-2-Nal-NHCH3 DMAQR29 MI TTD0CIQ DMAQR29 MN Melanocortin receptor 4 (MC4R) DMAQR29 MT DTT DMAQR29 MA Inhibitor DMAQR29 RN Design and synthesis of potent and selective 1,3,4-trisubstituted-2-oxopiperazine based melanocortin-4 receptor agonists. Bioorg Med Chem Lett. 2006 Sep 1;16(17):4668-73. DMAQR29 RU https://pubmed.ncbi.nlm.nih.gov/16766182 DMMP0D8 DI DMMP0D8 DMMP0D8 DN Ac-His-DPhe-Arg-Trp-NH2 DMMP0D8 MI TT0MV2T DMMP0D8 MN Melanocortin receptor 1 (MC1R) DMMP0D8 MT DTT DMMP0D8 MA Inhibitor DMMP0D8 RN Discovery of prototype peptidomimetic agonists at the human melanocortin receptors MC1R and MC4R. J Med Chem. 1997 Jul 4;40(14):2133-9. DMMP0D8 RU https://pubmed.ncbi.nlm.nih.gov/9216831 DMMP0D8 DI DMMP0D8 DMMP0D8 DN Ac-His-DPhe-Arg-Trp-NH2 DMMP0D8 MI TTD0CIQ DMMP0D8 MN Melanocortin receptor 4 (MC4R) DMMP0D8 MT DTT DMMP0D8 MA Inhibitor DMMP0D8 RN Discovery of prototype peptidomimetic agonists at the human melanocortin receptors MC1R and MC4R. J Med Chem. 1997 Jul 4;40(14):2133-9. DMMP0D8 RU https://pubmed.ncbi.nlm.nih.gov/9216831 DMCA4QR DI DMCA4QR DMCA4QR DN Ac-His-Trp-Ala-Val-Ala-His-Leu-Met-NH2 DMCA4QR MI TTC1MVT DMCA4QR MN Gastrin-releasing peptide receptor (GRPR) DMCA4QR MT DTT DMCA4QR MA Inhibitor DMCA4QR RN Gastrin releasing peptide antagonists with improved potency and stability. J Med Chem. 1991 Jul;34(7):2102-7. DMCA4QR RU https://pubmed.ncbi.nlm.nih.gov/2066982 DMUINVT DI DMUINVT DMUINVT DN Ac-His-Trp-Ala-Val-D-Ala-His-Leu-Met-NH2 DMUINVT MI TTC1MVT DMUINVT MN Gastrin-releasing peptide receptor (GRPR) DMUINVT MT DTT DMUINVT MA Inhibitor DMUINVT RN Gastrin releasing peptide antagonists with improved potency and stability. J Med Chem. 1991 Jul;34(7):2102-7. DMUINVT RU https://pubmed.ncbi.nlm.nih.gov/2066982 DMUGO9M DI DMUGO9M DMUGO9M DN Ac-His-Trp-Ala-Val-Gly-His-Leu-Met-NH2 DMUGO9M MI TTC1MVT DMUGO9M MN Gastrin-releasing peptide receptor (GRPR) DMUGO9M MT DTT DMUGO9M MA Inhibitor DMUGO9M RN Gastrin releasing peptide antagonists with improved potency and stability. J Med Chem. 1991 Jul;34(7):2102-7. DMUGO9M RU https://pubmed.ncbi.nlm.nih.gov/2066982 DMZO5Y7 DI DMZO5Y7 DMZO5Y7 DN ACHP DMZO5Y7 MI TTSXVID DMZO5Y7 MN Nuclear factor NF-kappa-B (NFKB) DMZO5Y7 MT DTT DMZO5Y7 MA Inhibitor DMZO5Y7 RN Emerging therapies for multiple myeloma. Expert Opin Emerg Drugs. 2009 Mar;14(1):99-127. DMZO5Y7 RU https://pubmed.ncbi.nlm.nih.gov/19249983 DMU7SBD DI DMU7SBD DMU7SBD DN Ac-hPhe-Leu-Ala-LeuVSMe DMU7SBD MI TTF2LRI DMU7SBD MN Cathepsin B (CTSB) DMU7SBD MT DTT DMU7SBD MA Inhibitor DMU7SBD RN Optimization of subsite binding to the beta5 subunit of the human 20S proteasome using vinyl sulfones and 2-keto-1,3,4-oxadiazoles: syntheses and c... J Med Chem. 2006 May 18;49(10):2953-68. DMU7SBD RU https://pubmed.ncbi.nlm.nih.gov/16686537 DMU7SBD DI DMU7SBD DMU7SBD DN Ac-hPhe-Leu-Ala-LeuVSMe DMU7SBD MI TTUMQVO DMU7SBD MN Cathepsin S (CTSS) DMU7SBD MT DTT DMU7SBD MA Inhibitor DMU7SBD RN Optimization of subsite binding to the beta5 subunit of the human 20S proteasome using vinyl sulfones and 2-keto-1,3,4-oxadiazoles: syntheses and c... J Med Chem. 2006 May 18;49(10):2953-68. DMU7SBD RU https://pubmed.ncbi.nlm.nih.gov/16686537 DMH2SU4 DI DMH2SU4 DMH2SU4 DN Ac-hPhe-Leu-Gly-LeuVSMe DMH2SU4 MI TTUMQVO DMH2SU4 MN Cathepsin S (CTSS) DMH2SU4 MT DTT DMH2SU4 MA Inhibitor DMH2SU4 RN Optimization of subsite binding to the beta5 subunit of the human 20S proteasome using vinyl sulfones and 2-keto-1,3,4-oxadiazoles: syntheses and c... J Med Chem. 2006 May 18;49(10):2953-68. DMH2SU4 RU https://pubmed.ncbi.nlm.nih.gov/16686537 DMMDJPC DI DMMDJPC DMMDJPC DN Ac-hPhe-Leu-Phe-LeuVSMe DMMDJPC MI TTF2LRI DMMDJPC MN Cathepsin B (CTSB) DMMDJPC MT DTT DMMDJPC MA Inhibitor DMMDJPC RN Optimization of subsite binding to the beta5 subunit of the human 20S proteasome using vinyl sulfones and 2-keto-1,3,4-oxadiazoles: syntheses and c... J Med Chem. 2006 May 18;49(10):2953-68. DMMDJPC RU https://pubmed.ncbi.nlm.nih.gov/16686537 DMMDJPC DI DMMDJPC DMMDJPC DN Ac-hPhe-Leu-Phe-LeuVSMe DMMDJPC MI TTUMQVO DMMDJPC MN Cathepsin S (CTSS) DMMDJPC MT DTT DMMDJPC MA Inhibitor DMMDJPC RN Optimization of subsite binding to the beta5 subunit of the human 20S proteasome using vinyl sulfones and 2-keto-1,3,4-oxadiazoles: syntheses and c... J Med Chem. 2006 May 18;49(10):2953-68. DMMDJPC RU https://pubmed.ncbi.nlm.nih.gov/16686537 DMV58GQ DI DMV58GQ DMV58GQ DN Ac-HSDAVFTDQYTRLRKQVAAKKYLQSIKQKRYC DMV58GQ MI TTZC9FV DMV58GQ MN Vasoactive intestinal polypeptide receptor (VIPR) DMV58GQ MT DTT DMV58GQ MA Inhibitor DMV58GQ RN Engineering of a VPAC2 receptor peptide agonist to impart dipeptidyl peptidase IV stability and enhance in vivo glucose disposal. J Med Chem. 2006 Dec 14;49(25):7545-8. DMV58GQ RU https://pubmed.ncbi.nlm.nih.gov/17149884 DMJVRPD DI DMJVRPD DMJVRPD DN Ac-I[CV(1Nal)QDWGAHRC]T DMJVRPD MI TTJGY7A DMJVRPD MN Complement C3 (CO3) DMJVRPD MT DTT DMJVRPD MA Inhibitor DMJVRPD RN Design and NMR characterization of active analogues of compstatin containing non-natural amino acids. J Med Chem. 2005 Jan 13;48(1):274-86. DMJVRPD RU https://pubmed.ncbi.nlm.nih.gov/15634022 DM14DEL DI DM14DEL DM14DEL DN Ac-I[CV(2Igl)QDWGAHRC]T DM14DEL MI TTJGY7A DM14DEL MN Complement C3 (CO3) DM14DEL MT DTT DM14DEL MA Inhibitor DM14DEL RN Design and NMR characterization of active analogues of compstatin containing non-natural amino acids. J Med Chem. 2005 Jan 13;48(1):274-86. DM14DEL RU https://pubmed.ncbi.nlm.nih.gov/15634022 DMQISG6 DI DMQISG6 DMQISG6 DN Ac-I[CV(2Igl)QDWGAHRC]T-NH2 DMQISG6 MI TTJGY7A DMQISG6 MN Complement C3 (CO3) DMQISG6 MT DTT DMQISG6 MA Inhibitor DMQISG6 RN Design and NMR characterization of active analogues of compstatin containing non-natural amino acids. J Med Chem. 2005 Jan 13;48(1):274-86. DMQISG6 RU https://pubmed.ncbi.nlm.nih.gov/15634022 DM20PEO DI DM20PEO DM20PEO DN Ac-I[CV(2Nal)QDWGAHRC]T DM20PEO MI TTJGY7A DM20PEO MN Complement C3 (CO3) DM20PEO MT DTT DM20PEO MA Inhibitor DM20PEO RN Design and NMR characterization of active analogues of compstatin containing non-natural amino acids. J Med Chem. 2005 Jan 13;48(1):274-86. DM20PEO RU https://pubmed.ncbi.nlm.nih.gov/15634022 DMX2IRY DI DMX2IRY DMX2IRY DN Ac-I[CV(2Nal)QDWGAHRC]T-NH2 DMX2IRY MI TTJGY7A DMX2IRY MN Complement C3 (CO3) DMX2IRY MT DTT DMX2IRY MA Inhibitor DMX2IRY RN Design and NMR characterization of active analogues of compstatin containing non-natural amino acids. J Med Chem. 2005 Jan 13;48(1):274-86. DMX2IRY RU https://pubmed.ncbi.nlm.nih.gov/15634022 DMDFKU3 DI DMDFKU3 DMDFKU3 DN Ac-I[CV(Bpa)QDWGAHRC]T DMDFKU3 MI TTJGY7A DMDFKU3 MN Complement C3 (CO3) DMDFKU3 MT DTT DMDFKU3 MA Inhibitor DMDFKU3 RN Design and NMR characterization of active analogues of compstatin containing non-natural amino acids. J Med Chem. 2005 Jan 13;48(1):274-86. DMDFKU3 RU https://pubmed.ncbi.nlm.nih.gov/15634022 DMZG46O DI DMZG46O DMZG46O DN Ac-I[CV(Bpa)QDWGAHRC]T-NH2 DMZG46O MI TTJGY7A DMZG46O MN Complement C3 (CO3) DMZG46O MT DTT DMZG46O MA Inhibitor DMZG46O RN Design and NMR characterization of active analogues of compstatin containing non-natural amino acids. J Med Chem. 2005 Jan 13;48(1):274-86. DMZG46O RU https://pubmed.ncbi.nlm.nih.gov/15634022 DM5NMVP DI DM5NMVP DM5NMVP DN Ac-I[CV(Bta)QDWGAHRC]T DM5NMVP MI TTJGY7A DM5NMVP MN Complement C3 (CO3) DM5NMVP MT DTT DM5NMVP MA Inhibitor DM5NMVP RN Design and NMR characterization of active analogues of compstatin containing non-natural amino acids. J Med Chem. 2005 Jan 13;48(1):274-86. DM5NMVP RU https://pubmed.ncbi.nlm.nih.gov/15634022 DMFLA5T DI DMFLA5T DMFLA5T DN Ac-I[CV(Bta)QDWGAHRC]T-NH2 DMFLA5T MI TTJGY7A DMFLA5T MN Complement C3 (CO3) DMFLA5T MT DTT DMFLA5T MA Inhibitor DMFLA5T RN Design and NMR characterization of active analogues of compstatin containing non-natural amino acids. J Med Chem. 2005 Jan 13;48(1):274-86. DMFLA5T RU https://pubmed.ncbi.nlm.nih.gov/15634022 DMO9VWH DI DMO9VWH DMO9VWH DN Ac-I[CV(Dht)QDWGAHRC]T DMO9VWH MI TTJGY7A DMO9VWH MN Complement C3 (CO3) DMO9VWH MT DTT DMO9VWH MA Inhibitor DMO9VWH RN Design and NMR characterization of active analogues of compstatin containing non-natural amino acids. J Med Chem. 2005 Jan 13;48(1):274-86. DMO9VWH RU https://pubmed.ncbi.nlm.nih.gov/15634022 DMY18ET DI DMY18ET DMY18ET DN Ac-I[CV(Yphs)QDWGAHRC]I-NH2 DMY18ET MI TTJGY7A DMY18ET MN Complement C3 (CO3) DMY18ET MT DTT DMY18ET MA Inhibitor DMY18ET RN Design and NMR characterization of active analogues of compstatin containing non-natural amino acids. J Med Chem. 2005 Jan 13;48(1):274-86. DMY18ET RU https://pubmed.ncbi.nlm.nih.gov/15634022 DMFOTYQ DI DMFOTYQ DMFOTYQ DN Ac-I[CVFQDWGHHRC]T-NH2 DMFOTYQ MI TTJGY7A DMFOTYQ MN Complement C3 (CO3) DMFOTYQ MT DTT DMFOTYQ MA Inhibitor DMFOTYQ RN Design and NMR characterization of active analogues of compstatin containing non-natural amino acids. J Med Chem. 2005 Jan 13;48(1):274-86. DMFOTYQ RU https://pubmed.ncbi.nlm.nih.gov/15634022 DMLU3PZ DI DMLU3PZ DMLU3PZ DN Ac-I[CVHQDWGHHRC]T-NH2 DMLU3PZ MI TTJGY7A DMLU3PZ MN Complement C3 (CO3) DMLU3PZ MT DTT DMLU3PZ MA Inhibitor DMLU3PZ RN Design and NMR characterization of active analogues of compstatin containing non-natural amino acids. J Med Chem. 2005 Jan 13;48(1):274-86. DMLU3PZ RU https://pubmed.ncbi.nlm.nih.gov/15634022 DMDPSBQ DI DMDPSBQ DMDPSBQ DN Ac-I[CVSQDWGHHRC]T-NH2 DMDPSBQ MI TTJGY7A DMDPSBQ MN Complement C3 (CO3) DMDPSBQ MT DTT DMDPSBQ MA Inhibitor DMDPSBQ RN Design and NMR characterization of active analogues of compstatin containing non-natural amino acids. J Med Chem. 2005 Jan 13;48(1):274-86. DMDPSBQ RU https://pubmed.ncbi.nlm.nih.gov/15634022 DMNVMB5 DI DMNVMB5 DMNVMB5 DN Ac-I[CVTQDWGHHRC]T-NH2 DMNVMB5 MI TTJGY7A DMNVMB5 MN Complement C3 (CO3) DMNVMB5 MT DTT DMNVMB5 MA Inhibitor DMNVMB5 RN Design and NMR characterization of active analogues of compstatin containing non-natural amino acids. J Med Chem. 2005 Jan 13;48(1):274-86. DMNVMB5 RU https://pubmed.ncbi.nlm.nih.gov/15634022 DMRSKIY DI DMRSKIY DMRSKIY DN Ac-I[CVVQDWGAHRC]T-NH2 DMRSKIY MI TTJGY7A DMRSKIY MN Complement C3 (CO3) DMRSKIY MT DTT DMRSKIY MA Inhibitor DMRSKIY RN Design and NMR characterization of active analogues of compstatin containing non-natural amino acids. J Med Chem. 2005 Jan 13;48(1):274-86. DMRSKIY RU https://pubmed.ncbi.nlm.nih.gov/15634022 DMUW3T4 DI DMUW3T4 DMUW3T4 DN Ac-I[CVWQDWG(Abu)HRC]T-NH2 DMUW3T4 MI TTJGY7A DMUW3T4 MN Complement C3 (CO3) DMUW3T4 MT DTT DMUW3T4 MA Inhibitor DMUW3T4 RN Design and NMR characterization of active analogues of compstatin containing non-natural amino acids. J Med Chem. 2005 Jan 13;48(1):274-86. DMUW3T4 RU https://pubmed.ncbi.nlm.nih.gov/15634022 DML5ZSJ DI DML5ZSJ DML5ZSJ DN Ac-I[CVWQDWGAHRC]dT DML5ZSJ MI TTJGY7A DML5ZSJ MN Complement C3 (CO3) DML5ZSJ MT DTT DML5ZSJ MA Inhibitor DML5ZSJ RN Design and NMR characterization of active analogues of compstatin containing non-natural amino acids. J Med Chem. 2005 Jan 13;48(1):274-86. DML5ZSJ RU https://pubmed.ncbi.nlm.nih.gov/15634022 DMV3PC7 DI DMV3PC7 DMV3PC7 DN Ac-I[CVWQDWGAHRC]T DMV3PC7 MI TTJGY7A DMV3PC7 MN Complement C3 (CO3) DMV3PC7 MT DTT DMV3PC7 MA Inhibitor DMV3PC7 RN Design and NMR characterization of active analogues of compstatin containing non-natural amino acids. J Med Chem. 2005 Jan 13;48(1):274-86. DMV3PC7 RU https://pubmed.ncbi.nlm.nih.gov/15634022 DMBA1LS DI DMBA1LS DMBA1LS DN Ac-I[CVWQDWGHHRC]T-NH2 DMBA1LS MI TTJGY7A DMBA1LS MN Complement C3 (CO3) DMBA1LS MT DTT DMBA1LS MA Inhibitor DMBA1LS RN Design and NMR characterization of active analogues of compstatin containing non-natural amino acids. J Med Chem. 2005 Jan 13;48(1):274-86. DMBA1LS RU https://pubmed.ncbi.nlm.nih.gov/15634022 DMDIUK6 DI DMDIUK6 DMDIUK6 DN Ac-I[CVWQDWGWHRC]T-NH2 DMDIUK6 MI TTJGY7A DMDIUK6 MN Complement C3 (CO3) DMDIUK6 MT DTT DMDIUK6 MA Inhibitor DMDIUK6 RN Design and NMR characterization of active analogues of compstatin containing non-natural amino acids. J Med Chem. 2005 Jan 13;48(1):274-86. DMDIUK6 RU https://pubmed.ncbi.nlm.nih.gov/15634022 DM3Q5SU DI DM3Q5SU DM3Q5SU DN Ac-I[CVYQDWGAHRC]T-NH2 DM3Q5SU MI TTJGY7A DM3Q5SU MN Complement C3 (CO3) DM3Q5SU MT DTT DM3Q5SU MA Inhibitor DM3Q5SU RN Design and NMR characterization of active analogues of compstatin containing non-natural amino acids. J Med Chem. 2005 Jan 13;48(1):274-86. DM3Q5SU RU https://pubmed.ncbi.nlm.nih.gov/15634022 DMPLNTM DI DMPLNTM DMPLNTM DN ACI-636 DMPLNTM MI TTE4KHA DMPLNTM MN Amyloid beta A4 protein (APP) DMPLNTM MT DTT DMPLNTM MA Inhibitor DMPLNTM RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2402). DMPLNTM RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2402 DM351NL DI DM351NL DM351NL DN Ac-ICV(1MeW)QDWGAHRCT-NH2 DM351NL MI TTJGY7A DM351NL MN Complement C3 (CO3) DM351NL MT DTT DM351NL MA Inhibitor DM351NL RN Hydrophobic effect and hydrogen bonds account for the improved activity of a complement inhibitor, compstatin. J Med Chem. 2006 Jul 27;49(15):4616-22. DM351NL RU https://pubmed.ncbi.nlm.nih.gov/16854067 DMQLPGA DI DMQLPGA DMQLPGA DN Ac-ICV(5fW)QDWGAHRCT-NH2 DMQLPGA MI TTJGY7A DMQLPGA MN Complement C3 (CO3) DMQLPGA MT DTT DMQLPGA MA Inhibitor DMQLPGA RN Hydrophobic effect and hydrogen bonds account for the improved activity of a complement inhibitor, compstatin. J Med Chem. 2006 Jul 27;49(15):4616-22. DMQLPGA RU https://pubmed.ncbi.nlm.nih.gov/16854067 DM52T90 DI DM52T90 DM52T90 DN Ac-ICV(5MeW)QDWGAHRCT-NH2 DM52T90 MI TTJGY7A DM52T90 MN Complement C3 (CO3) DM52T90 MT DTT DM52T90 MA Inhibitor DM52T90 RN Hydrophobic effect and hydrogen bonds account for the improved activity of a complement inhibitor, compstatin. J Med Chem. 2006 Jul 27;49(15):4616-22. DM52T90 RU https://pubmed.ncbi.nlm.nih.gov/16854067 DMPK9LG DI DMPK9LG DMPK9LG DN Ac-ICVWQD(5fW)GAHRCT-NH2 DMPK9LG MI TTJGY7A DMPK9LG MN Complement C3 (CO3) DMPK9LG MT DTT DMPK9LG MA Inhibitor DMPK9LG RN Hydrophobic effect and hydrogen bonds account for the improved activity of a complement inhibitor, compstatin. J Med Chem. 2006 Jul 27;49(15):4616-22. DMPK9LG RU https://pubmed.ncbi.nlm.nih.gov/16854067 DMPSI26 DI DMPSI26 DMPSI26 DN Ac-ICVWQDWGAHRCT-NH2 DMPSI26 MI TTJGY7A DMPSI26 MN Complement C3 (CO3) DMPSI26 MT DTT DMPSI26 MA Inhibitor DMPSI26 RN Hydrophobic effect and hydrogen bonds account for the improved activity of a complement inhibitor, compstatin. J Med Chem. 2006 Jul 27;49(15):4616-22. DMPSI26 RU https://pubmed.ncbi.nlm.nih.gov/16854067 DMCU6XV DI DMCU6XV DMCU6XV DN Acid blue 25 DMCU6XV MI TTK0O6Y DMCU6XV MN Ecto-5'-nucleotidase (CD73) DMCU6XV MT DTT DMCU6XV MA Inhibitor DMCU6XV RN Development of potent and selective inhibitors of ecto-5'-nucleotidase based on an anthraquinone scaffold. J Med Chem. 2010 Mar 11;53(5):2076-86. DMCU6XV RU https://pubmed.ncbi.nlm.nih.gov/20146483 DMCU6XV DI DMCU6XV DMCU6XV DN Acid blue 25 DMCU6XV MI TTOZHQC DMCU6XV MN P2Y purinoceptor 2 (P2RY2) DMCU6XV MT DTT DMCU6XV MA Inhibitor DMCU6XV RN Development of potent and selective inhibitors of ecto-5'-nucleotidase based on an anthraquinone scaffold. J Med Chem. 2010 Mar 11;53(5):2076-86. DMCU6XV RU https://pubmed.ncbi.nlm.nih.gov/20146483 DMTOEJX DI DMTOEJX DMTOEJX DN Acid-activated omeprazole DMTOEJX MI TT30NW6 DMTOEJX MN Chloride channel protein 2 (CLC-2) DMTOEJX MT DTT DMTOEJX MA Activator DMTOEJX RN ClC-2 Cl- channels in human lung epithelia: activation by arachidonic acid, amidation, and acid-activated omeprazole. Am J Physiol Cell Physiol. 2001 Jul;281(1):C46-54. DMTOEJX RU https://pubmed.ncbi.nlm.nih.gov/11401826 DMTOEJX DI DMTOEJX DMTOEJX DN Acid-activated omeprazole DMTOEJX MI TTZN7RP DMTOEJX MN Rho-associated protein kinase 1 (ROCK1) DMTOEJX MT DTT DMTOEJX MA Inhibitor DMTOEJX RN Long-term treatment with a specific Rho-kinase inhibitor suppresses cardiac allograft vasculopathy in mice. Circ Res. 2004 Jan 9;94(1):46-52. DMTOEJX RU https://pubmed.ncbi.nlm.nih.gov/14615290 DMKVU8P DI DMKVU8P DMKVU8P DN Ac-L-Phe-D-trp-L-Phe-D-pro-NH2 DMKVU8P MI TTKWM86 DMKVU8P MN Opioid receptor mu (MOP) DMKVU8P MT DTT DMKVU8P MA Inhibitor DMKVU8P RN Nascent structure-activity relationship study of a diastereomeric series of kappa opioid receptor antagonists derived from CJ-15,208. Bioorg Med Chem Lett. 2009 Jul 1;19(13):3647-50. DMKVU8P RU https://pubmed.ncbi.nlm.nih.gov/19464172 DMIAYTP DI DMIAYTP DMIAYTP DN Ac-Lys-[Leu(8)]-des-Arg(9)-BK DMIAYTP MI TTG5QIA DMIAYTP MN B1 bradykinin receptor (BDKRB1) DMIAYTP MT DTT DMIAYTP MA Antagonist DMIAYTP RN Non-competitive pharmacological antagonism at the rabbit B(1) receptor. Br J Pharmacol. 2000 Nov;131(5):885-92. DMIAYTP RU https://pubmed.ncbi.nlm.nih.gov/11053207 DMRQ70X DI DMRQ70X DMRQ70X DN ACMC-1AKLT DMRQ70X MI DEYGVN4 DMRQ70X MN UDP-glucuronosyltransferase 1A1 (UGT1A1) DMRQ70X MT DME DMRQ70X MA Metabolism DMRQ70X RN Functional characterization of human and cynomolgus monkey UDP-glucuronosyltransferase 1A1 enzymes. Life Sci. 2010 Aug 14;87(7-8):261-8. DMRQ70X RU https://www.ncbi.nlm.nih.gov/pubmed/?term=20620155 DMQCSFB DI DMQCSFB DMQCSFB DN ACMC-209cv7 DMQCSFB MI DEIVKZ8 DMQCSFB MN NADPH-dependent carbonyl reductase 3 (CBR3) DMQCSFB MT DME DMQCSFB MA Metabolism DMQCSFB RN Different functions between human monomeric carbonyl reductase 3 and carbonyl reductase 1. Mol Cell Biochem. 2008 Aug;315(1-2):113-21. DMQCSFB RU https://www.ncbi.nlm.nih.gov/pubmed/?term=18493841 DM3E4QR DI DM3E4QR DM3E4QR DN ACN-1052 DM3E4QR MI TTJFY5U DM3E4QR MN Adenosine A3 receptor (ADORA3) DM3E4QR MT DTT DM3E4QR MA Antagonist DM3E4QR RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 21). DM3E4QR RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=21 DMLYGPW DI DMLYGPW DMLYGPW DN Ac-Nle-c[Asp-His-DNaI(2')-Pro-Trp-Lys]-NH2 DMLYGPW MI TT0MV2T DMLYGPW MN Melanocortin receptor 1 (MC1R) DMLYGPW MT DTT DMLYGPW MA Inhibitor DMLYGPW RN Substitution of arginine with proline and proline derivatives in melanocyte-stimulating hormones leads to selectivity for human melanocortin 4 rece... J Med Chem. 2009 Jun 25;52(12):3627-35. DMLYGPW RU https://pubmed.ncbi.nlm.nih.gov/19473029 DMLYGPW DI DMLYGPW DMLYGPW DN Ac-Nle-c[Asp-His-DNaI(2')-Pro-Trp-Lys]-NH2 DMLYGPW MI TTD0CIQ DMLYGPW MN Melanocortin receptor 4 (MC4R) DMLYGPW MT DTT DMLYGPW MA Inhibitor DMLYGPW RN Substitution of arginine with proline and proline derivatives in melanocyte-stimulating hormones leads to selectivity for human melanocortin 4 rece... J Med Chem. 2009 Jun 25;52(12):3627-35. DMLYGPW RU https://pubmed.ncbi.nlm.nih.gov/19473029 DMOVI7Y DI DMOVI7Y DMOVI7Y DN Ac-Nle-c[Asp-His-DNal(2')-Pro-Trp-Lys]-NH2 DMOVI7Y MI TTEOSZT DMOVI7Y MN Melanocortin receptor (MCR) DMOVI7Y MT DTT DMOVI7Y MA Inhibitor DMOVI7Y RN Substitution of arginine with proline and proline derivatives in melanocyte-stimulating hormones leads to selectivity for human melanocortin 4 rece... J Med Chem. 2009 Jun 25;52(12):3627-35. DMOVI7Y RU https://pubmed.ncbi.nlm.nih.gov/19473029 DMOVI7Y DI DMOVI7Y DMOVI7Y DN Ac-Nle-c[Asp-His-DNal(2')-Pro-Trp-Lys]-NH2 DMOVI7Y MI TT0MV2T DMOVI7Y MN Melanocortin receptor 1 (MC1R) DMOVI7Y MT DTT DMOVI7Y MA Inhibitor DMOVI7Y RN Substitution of arginine with proline and proline derivatives in melanocyte-stimulating hormones leads to selectivity for human melanocortin 4 rece... J Med Chem. 2009 Jun 25;52(12):3627-35. DMOVI7Y RU https://pubmed.ncbi.nlm.nih.gov/19473029 DMOVI7Y DI DMOVI7Y DMOVI7Y DN Ac-Nle-c[Asp-His-DNal(2')-Pro-Trp-Lys]-NH2 DMOVI7Y MI TTNI91K DMOVI7Y MN Melanocortin receptor 3 (MC3R) DMOVI7Y MT DTT DMOVI7Y MA Inhibitor DMOVI7Y RN Substitution of arginine with proline and proline derivatives in melanocyte-stimulating hormones leads to selectivity for human melanocortin 4 rece... J Med Chem. 2009 Jun 25;52(12):3627-35. DMOVI7Y RU https://pubmed.ncbi.nlm.nih.gov/19473029 DMOVI7Y DI DMOVI7Y DMOVI7Y DN Ac-Nle-c[Asp-His-DNal(2')-Pro-Trp-Lys]-NH2 DMOVI7Y MI TTD0CIQ DMOVI7Y MN Melanocortin receptor 4 (MC4R) DMOVI7Y MT DTT DMOVI7Y MA Inhibitor DMOVI7Y RN Substitution of arginine with proline and proline derivatives in melanocyte-stimulating hormones leads to selectivity for human melanocortin 4 rece... J Med Chem. 2009 Jun 25;52(12):3627-35. DMOVI7Y RU https://pubmed.ncbi.nlm.nih.gov/19473029 DMG418C DI DMG418C DMG418C DN AC-Nle-c[Asp-His-DPhe-Pro-Trp-Lys]-NH2 DMG418C MI TTD0CIQ DMG418C MN Melanocortin receptor 4 (MC4R) DMG418C MT DTT DMG418C MA Inhibitor DMG418C RN Substitution of arginine with proline and proline derivatives in melanocyte-stimulating hormones leads to selectivity for human melanocortin 4 rece... J Med Chem. 2009 Jun 25;52(12):3627-35. DMG418C RU https://pubmed.ncbi.nlm.nih.gov/19473029 DMZBOQW DI DMZBOQW DMZBOQW DN AcNPY(25-36) DMZBOQW MI TTJ6WK9 DMZBOQW MN Neuropeptide Y receptor type 2 (NPY2R) DMZBOQW MT DTT DMZBOQW MA Inhibitor DMZBOQW RN Identification of selective neuropeptide Y2 peptide agonists. Bioorg Med Chem Lett. 2007 Jan 15;17(2):538-41. DMZBOQW RU https://pubmed.ncbi.nlm.nih.gov/17055726 DMQ0YW7 DI DMQ0YW7 DMQ0YW7 DN Acocantherin DMQ0YW7 MI TTWNK8B DMQ0YW7 MN HUMAN sodium pump subunit alpha-1 (ATP1A1) DMQ0YW7 MT DTT DMQ0YW7 MA Inhibitor DMQ0YW7 RN Coronaviruses - drug discovery and therapeutic options. Nat Rev Drug Discov. 2016 May;15(5):327-47. DMQ0YW7 RU https://pubmed.ncbi.nlm.nih.gov/26868298 DMJ5U8C DI DMJ5U8C DMJ5U8C DN Aconitate Ion DMJ5U8C MI TTMTF2P DMJ5U8C MN Citrate hydro-lyase (ACO2) DMJ5U8C MT DTT DMJ5U8C MA Inhibitor DMJ5U8C RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMJ5U8C RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMFOZ60 DI DMFOZ60 DMFOZ60 DN aconitine DMFOZ60 MI TTLJTUF DMFOZ60 MN Voltage-gated sodium channel alpha Nav1.2 (SCN2A) DMFOZ60 MT DTT DMFOZ60 MA Activator DMFOZ60 RN Binding of batrachotoxinin A 20-alpha-benzoate to a receptor site associated with sodium channels in synaptic nerve ending particles. J Biol Chem. 1981 Sep 10;256(17):8922-7. DMFOZ60 RU https://pubmed.ncbi.nlm.nih.gov/6114956 DMFOZ60 DI DMFOZ60 DMFOZ60 DN aconitine DMFOZ60 MI TTZOVE0 DMFOZ60 MN Voltage-gated sodium channel alpha Nav1.5 (SCN5A) DMFOZ60 MT DTT DMFOZ60 MA Activator DMFOZ60 RN Properties of aconitine-modified sodium channels in single cells of mouse ventricular myocardium. Gen Physiol Biophys. 1986 Oct;5(5):473-84. DMFOZ60 RU https://pubmed.ncbi.nlm.nih.gov/2433183 DMBVHLT DI DMBVHLT DMBVHLT DN ACP-106 DMBVHLT MI TTJQOD7 DMBVHLT MN 5-HT 2A receptor (HTR2A) DMBVHLT MT DTT DMBVHLT MA Agonist DMBVHLT RN Pharmacological profile of the new potent neuroleptic ocaperidone (R 79,598). J Pharmacol Exp Ther. 1992 Jan;260(1):146-59. DMBVHLT RU https://pubmed.ncbi.nlm.nih.gov/1370538 DMAZLWR DI DMAZLWR DMAZLWR DN ACPC DMAZLWR MI TT9IK2Z DMAZLWR MN N-methyl-D-aspartate receptor (NMDAR) DMAZLWR MT DTT DMAZLWR MA Modulator DMAZLWR RN 1-Aminocyclopropane carboxylic acid (ACPC) prevents mu and delta opioid tolerance. Life Sci. 1994;55(18):1393-8. DMAZLWR RU https://pubmed.ncbi.nlm.nih.gov/7934650 DM6ONY7 DI DM6ONY7 DM6ONY7 DN Ac-Phe-D-Thr(PO3H2)-Pip-Nal-Gln-NH2 DM6ONY7 MI TTJNTSI DM6ONY7 MN Rotamase Pin1 (PIN1) DM6ONY7 MT DTT DM6ONY7 MA Inhibitor DM6ONY7 RN Nanomolar inhibitors of the peptidyl prolyl cis/trans isomerase Pin1 from combinatorial peptide libraries. J Med Chem. 2006 Apr 6;49(7):2147-50. DM6ONY7 RU https://pubmed.ncbi.nlm.nih.gov/16570909 DMDXBQA DI DMDXBQA DMDXBQA DN Ac-Phe-Phe-NH2 DMDXBQA MI TTZPO1L DMDXBQA MN Substance-P receptor (TACR1) DMDXBQA MT DTT DMDXBQA MA Inhibitor DMDXBQA RN Discovery of dipeptides with high affinity to the specific binding site for substance P1-7. J Med Chem. 2010 Mar 25;53(6):2383-9. DMDXBQA RU https://pubmed.ncbi.nlm.nih.gov/20178322 DMSWTPX DI DMSWTPX DMSWTPX DN Ac-Phe-Thr(PO3H2)-Pip-Nal-Gln-NH2 DMSWTPX MI TTJNTSI DMSWTPX MN Rotamase Pin1 (PIN1) DMSWTPX MT DTT DMSWTPX MA Inhibitor DMSWTPX RN Nanomolar inhibitors of the peptidyl prolyl cis/trans isomerase Pin1 from combinatorial peptide libraries. J Med Chem. 2006 Apr 6;49(7):2147-50. DMSWTPX RU https://pubmed.ncbi.nlm.nih.gov/16570909 DM264XN DI DM264XN DM264XN DN ACPT-I DM264XN MI TTICZ1O DM264XN MN Metabotropic glutamate receptor 4 (mGluR4) DM264XN MT DTT DM264XN MA Agonist DM264XN RN Synthesis and pharmacological characterization of aminocyclopentanetricarboxylic acids: new tools to discriminate between metabotropic glutamate receptor subtypes. J Med Chem. 1997 Sep 12;40(19):3119-29. DM264XN RU https://pubmed.ncbi.nlm.nih.gov/9301676 DM264XN DI DM264XN DM264XN DN ACPT-I DM264XN MI TTWRP2F DM264XN MN Metabotropic glutamate receptor 6 (mGluR6) DM264XN MT DTT DM264XN MA Agonist DM264XN RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 294). DM264XN RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=294 DM264XN DI DM264XN DM264XN DN ACPT-I DM264XN MI TT0IFKL DM264XN MN Metabotropic glutamate receptor 8 (mGluR8) DM264XN MT DTT DM264XN MA Agonist DM264XN RN Pharmacological characterization of the rat metabotropic glutamate receptor type 8a revealed strong similarities and slight differences with the type 4a receptor. Eur J Pharmacol. 2000 Apr 7;394(1):17-26. DM264XN RU https://pubmed.ncbi.nlm.nih.gov/10771029 DMDEFPS DI DMDEFPS DMDEFPS DN AcPYY(22-36) DMDEFPS MI TTRK9JT DMDEFPS MN Neuropeptide Y receptor type 1 (NPY1R) DMDEFPS MT DTT DMDEFPS MA Inhibitor DMDEFPS RN Identification of selective neuropeptide Y2 peptide agonists. Bioorg Med Chem Lett. 2007 Jan 15;17(2):538-41. DMDEFPS RU https://pubmed.ncbi.nlm.nih.gov/17055726 DMDEFPS DI DMDEFPS DMDEFPS DN AcPYY(22-36) DMDEFPS MI TTJ6WK9 DMDEFPS MN Neuropeptide Y receptor type 2 (NPY2R) DMDEFPS MT DTT DMDEFPS MA Inhibitor DMDEFPS RN Identification of selective neuropeptide Y2 peptide agonists. Bioorg Med Chem Lett. 2007 Jan 15;17(2):538-41. DMDEFPS RU https://pubmed.ncbi.nlm.nih.gov/17055726 DMRSU2K DI DMRSU2K DMRSU2K DN AcPYY(25-36) DMRSU2K MI TTJ6WK9 DMRSU2K MN Neuropeptide Y receptor type 2 (NPY2R) DMRSU2K MT DTT DMRSU2K MA Inhibitor DMRSU2K RN Identification of selective neuropeptide Y2 peptide agonists. Bioorg Med Chem Lett. 2007 Jan 15;17(2):538-41. DMRSU2K RU https://pubmed.ncbi.nlm.nih.gov/17055726 DM7RELC DI DM7RELC DM7RELC DN AcPYY(26-36) DM7RELC MI TTJ6WK9 DM7RELC MN Neuropeptide Y receptor type 2 (NPY2R) DM7RELC MT DTT DM7RELC MA Inhibitor DM7RELC RN Identification of selective neuropeptide Y2 peptide agonists. Bioorg Med Chem Lett. 2007 Jan 15;17(2):538-41. DM7RELC RU https://pubmed.ncbi.nlm.nih.gov/17055726 DMBFUD0 DI DMBFUD0 DMBFUD0 DN Ac-R[CEHdFRWC]-NH2 DMBFUD0 MI TT0MV2T DMBFUD0 MN Melanocortin receptor 1 (MC1R) DMBFUD0 MT DTT DMBFUD0 MA Inhibitor DMBFUD0 RN Discovery of a beta-MSH-derived MC-4R selective agonist. J Med Chem. 2005 May 5;48(9):3095-8. DMBFUD0 RU https://pubmed.ncbi.nlm.nih.gov/15857110 DMBFUD0 DI DMBFUD0 DMBFUD0 DN Ac-R[CEHdFRWC]-NH2 DMBFUD0 MI TTNI91K DMBFUD0 MN Melanocortin receptor 3 (MC3R) DMBFUD0 MT DTT DMBFUD0 MA Inhibitor DMBFUD0 RN Discovery of a beta-MSH-derived MC-4R selective agonist. J Med Chem. 2005 May 5;48(9):3095-8. DMBFUD0 RU https://pubmed.ncbi.nlm.nih.gov/15857110 DMBFUD0 DI DMBFUD0 DMBFUD0 DN Ac-R[CEHdFRWC]-NH2 DMBFUD0 MI TTD0CIQ DMBFUD0 MN Melanocortin receptor 4 (MC4R) DMBFUD0 MT DTT DMBFUD0 MA Inhibitor DMBFUD0 RN Discovery of a beta-MSH-derived MC-4R selective agonist. J Med Chem. 2005 May 5;48(9):3095-8. DMBFUD0 RU https://pubmed.ncbi.nlm.nih.gov/15857110 DMYZJ5B DI DMYZJ5B DMYZJ5B DN Acriflavinium chloride DMYZJ5B MI DE6OQ3W DMYZJ5B MN Cytochrome P450 1A1 (CYP1A1) DMYZJ5B MT DME DMYZJ5B MA Metabolism DMYZJ5B RN Activation of the antitumor agent aminoflavone (NSC 686288) is mediated by induction of tumor cell cytochrome P450 1A1/1A2. Mol Pharmacol. 2002 Jul;62(1):143-53. DMYZJ5B RU https://www.ncbi.nlm.nih.gov/pubmed/?term=12065765 DMYZJ5B DI DMYZJ5B DMYZJ5B DN Acriflavinium chloride DMYZJ5B MI DEJGDUW DMYZJ5B MN Cytochrome P450 1A2 (CYP1A2) DMYZJ5B MT DME DMYZJ5B MA Metabolism DMYZJ5B RN Activation of the antitumor agent aminoflavone (NSC 686288) is mediated by induction of tumor cell cytochrome P450 1A1/1A2. Mol Pharmacol. 2002 Jul;62(1):143-53. DMYZJ5B RU https://www.ncbi.nlm.nih.gov/pubmed/?term=12065765 DMAMCSR DI DMAMCSR DMAMCSR DN acrolein DMAMCSR MI TTELV3W DMAMCSR MN Transformation-sensitive protein p120 (TRPA1) DMAMCSR MT DTT DMAMCSR MA Activator DMAMCSR RN TRPA1 mediates the inflammatory actions of environmental irritants and proalgesic agents. Cell. 2006 Mar 24;124(6):1269-82. DMAMCSR RU https://pubmed.ncbi.nlm.nih.gov/16564016 DM512OP DI DM512OP DM512OP DN Ac-RYYRIK-GGG-K-(NH2)-YAFGYPS-GG DM512OP MI TTNT7K8 DM512OP MN Nociceptin receptor (OPRL1) DM512OP MT DTT DM512OP MA Inhibitor DM512OP RN Synthesis and receptor binding properties of chimeric peptides containing a mu-opioid receptor ligand and nociceptin/orphanin FQ receptor ligand Ac... Bioorg Med Chem Lett. 2006 Sep 15;16(18):4839-41. DM512OP RU https://pubmed.ncbi.nlm.nih.gov/16814543 DM512OP DI DM512OP DM512OP DN Ac-RYYRIK-GGG-K-(NH2)-YAFGYPS-GG DM512OP MI TTKWM86 DM512OP MN Opioid receptor mu (MOP) DM512OP MT DTT DM512OP MA Inhibitor DM512OP RN Synthesis and receptor binding properties of chimeric peptides containing a mu-opioid receptor ligand and nociceptin/orphanin FQ receptor ligand Ac... Bioorg Med Chem Lett. 2006 Sep 15;16(18):4839-41. DM512OP RU https://pubmed.ncbi.nlm.nih.gov/16814543 DMAHQIV DI DMAHQIV DMAHQIV DN Ac-RYYRIK-GGG-K-(NH2)-YRFB-GGGGG DMAHQIV MI TTNT7K8 DMAHQIV MN Nociceptin receptor (OPRL1) DMAHQIV MT DTT DMAHQIV MA Inhibitor DMAHQIV RN Synthesis and receptor binding properties of chimeric peptides containing a mu-opioid receptor ligand and nociceptin/orphanin FQ receptor ligand Ac... Bioorg Med Chem Lett. 2006 Sep 15;16(18):4839-41. DMAHQIV RU https://pubmed.ncbi.nlm.nih.gov/16814543 DMAHQIV DI DMAHQIV DMAHQIV DN Ac-RYYRIK-GGG-K-(NH2)-YRFB-GGGGG DMAHQIV MI TTKWM86 DMAHQIV MN Opioid receptor mu (MOP) DMAHQIV MT DTT DMAHQIV MA Inhibitor DMAHQIV RN Synthesis and receptor binding properties of chimeric peptides containing a mu-opioid receptor ligand and nociceptin/orphanin FQ receptor ligand Ac... Bioorg Med Chem Lett. 2006 Sep 15;16(18):4839-41. DMAHQIV RU https://pubmed.ncbi.nlm.nih.gov/16814543 DM2ND3U DI DM2ND3U DM2ND3U DN Ac-RYYRIK-K-(NH2)-YAFGYPS DM2ND3U MI TTNT7K8 DM2ND3U MN Nociceptin receptor (OPRL1) DM2ND3U MT DTT DM2ND3U MA Inhibitor DM2ND3U RN Synthesis and receptor binding properties of chimeric peptides containing a mu-opioid receptor ligand and nociceptin/orphanin FQ receptor ligand Ac... Bioorg Med Chem Lett. 2006 Sep 15;16(18):4839-41. DM2ND3U RU https://pubmed.ncbi.nlm.nih.gov/16814543 DM2ND3U DI DM2ND3U DM2ND3U DN Ac-RYYRIK-K-(NH2)-YAFGYPS DM2ND3U MI TTKWM86 DM2ND3U MN Opioid receptor mu (MOP) DM2ND3U MT DTT DM2ND3U MA Inhibitor DM2ND3U RN Synthesis and receptor binding properties of chimeric peptides containing a mu-opioid receptor ligand and nociceptin/orphanin FQ receptor ligand Ac... Bioorg Med Chem Lett. 2006 Sep 15;16(18):4839-41. DM2ND3U RU https://pubmed.ncbi.nlm.nih.gov/16814543 DMNA3F4 DI DMNA3F4 DMNA3F4 DN Ac-RYYRIK-K-(NH2)-YRFB DMNA3F4 MI TTNT7K8 DMNA3F4 MN Nociceptin receptor (OPRL1) DMNA3F4 MT DTT DMNA3F4 MA Inhibitor DMNA3F4 RN Synthesis and receptor binding properties of chimeric peptides containing a mu-opioid receptor ligand and nociceptin/orphanin FQ receptor ligand Ac... Bioorg Med Chem Lett. 2006 Sep 15;16(18):4839-41. DMNA3F4 RU https://pubmed.ncbi.nlm.nih.gov/16814543 DMNA3F4 DI DMNA3F4 DMNA3F4 DN Ac-RYYRIK-K-(NH2)-YRFB DMNA3F4 MI TTKWM86 DMNA3F4 MN Opioid receptor mu (MOP) DMNA3F4 MT DTT DMNA3F4 MA Inhibitor DMNA3F4 RN Synthesis and receptor binding properties of chimeric peptides containing a mu-opioid receptor ligand and nociceptin/orphanin FQ receptor ligand Ac... Bioorg Med Chem Lett. 2006 Sep 15;16(18):4839-41. DMNA3F4 RU https://pubmed.ncbi.nlm.nih.gov/16814543 DMI87UE DI DMI87UE DMI87UE DN Ac-RYYRIK-NH2 DMI87UE MI TTNT7K8 DMI87UE MN Nociceptin receptor (OPRL1) DMI87UE MT DTT DMI87UE MA Inhibitor DMI87UE RN Synthesis and receptor binding properties of chimeric peptides containing a mu-opioid receptor ligand and nociceptin/orphanin FQ receptor ligand Ac... Bioorg Med Chem Lett. 2006 Sep 15;16(18):4839-41. DMI87UE RU https://pubmed.ncbi.nlm.nih.gov/16814543 DM8XBR1 DI DM8XBR1 DM8XBR1 DN Ac-SFWKYS-NH2 DM8XBR1 MI TTW5UDX DM8XBR1 MN Urotensin II receptor (UTS2R) DM8XBR1 MT DTT DM8XBR1 MA Inhibitor DM8XBR1 RN Urotensin-II receptor modulators as potential drugs. J Med Chem. 2010 Apr 8;53(7):2695-708. DM8XBR1 RU https://pubmed.ncbi.nlm.nih.gov/20043680 DMPHSU8 DI DMPHSU8 DMPHSU8 DN ACTB-1003 DMPHSU8 MI TTRLW2X DMPHSU8 MN Fibroblast growth factor receptor 1 (FGFR1) DMPHSU8 MT DTT DMPHSU8 MA Inhibitor DMPHSU8 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1808). DMPHSU8 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1808 DMPHSU8 DI DMPHSU8 DMPHSU8 DN ACTB-1003 DMPHSU8 MI TTGJVQM DMPHSU8 MN Fibroblast growth factor receptor 2 (FGFR2) DMPHSU8 MT DTT DMPHSU8 MA Inhibitor DMPHSU8 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1809). DMPHSU8 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1809 DMPHSU8 DI DMPHSU8 DMPHSU8 DN ACTB-1003 DMPHSU8 MI TTST7KB DMPHSU8 MN Fibroblast growth factor receptor 3 (FGFR3) DMPHSU8 MT DTT DMPHSU8 MA Inhibitor DMPHSU8 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1810). DMPHSU8 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1810 DMPHSU8 DI DMPHSU8 DMPHSU8 DN ACTB-1003 DMPHSU8 MI TT5BR7T DMPHSU8 MN Fibroblast growth factor receptor 4 (FGFR4) DMPHSU8 MT DTT DMPHSU8 MA Inhibitor DMPHSU8 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1811). DMPHSU8 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1811 DMPHSU8 DI DMPHSU8 DMPHSU8 DN ACTB-1003 DMPHSU8 MI TTG0U4H DMPHSU8 MN Ribosomal protein S6 kinase beta-1 (S6K1) DMPHSU8 MT DTT DMPHSU8 MA Inhibitor DMPHSU8 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1525). DMPHSU8 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1525 DMXIDS9 DI DMXIDS9 DMXIDS9 DN ACTINOPLANIC ACID A DMXIDS9 MI TT7WZIJ DMXIDS9 MN CAAX farnesyltransferase beta (FNTB) DMXIDS9 MT DTT DMXIDS9 MA Inhibitor DMXIDS9 RN Ras farnesyltransferase: a new therapeutic target. J Med Chem. 1997 Sep 12;40(19):2971-90. DMXIDS9 RU https://pubmed.ncbi.nlm.nih.gov/9301658 DMXIDS9 DI DMXIDS9 DMXIDS9 DN ACTINOPLANIC ACID A DMXIDS9 MI TTXQKM3 DMXIDS9 MN Farnesyl protein transferase (Ftase) DMXIDS9 MT DTT DMXIDS9 MA Inhibitor DMXIDS9 RN Ras farnesyltransferase: a new therapeutic target. J Med Chem. 1997 Sep 12;40(19):2971-90. DMXIDS9 RU https://pubmed.ncbi.nlm.nih.gov/9301658 DMIH5CD DI DMIH5CD DMIH5CD DN Ac-Tyr-D-Phe-Arg-2-Nal-NHCH3 DMIH5CD MI TT0MV2T DMIH5CD MN Melanocortin receptor 1 (MC1R) DMIH5CD MT DTT DMIH5CD MA Inhibitor DMIH5CD RN Design and synthesis of potent and selective 1,3,4-trisubstituted-2-oxopiperazine based melanocortin-4 receptor agonists. Bioorg Med Chem Lett. 2006 Sep 1;16(17):4668-73. DMIH5CD RU https://pubmed.ncbi.nlm.nih.gov/16766182 DMIH5CD DI DMIH5CD DMIH5CD DN Ac-Tyr-D-Phe-Arg-2-Nal-NHCH3 DMIH5CD MI TTNI91K DMIH5CD MN Melanocortin receptor 3 (MC3R) DMIH5CD MT DTT DMIH5CD MA Inhibitor DMIH5CD RN Design and synthesis of potent and selective 1,3,4-trisubstituted-2-oxopiperazine based melanocortin-4 receptor agonists. Bioorg Med Chem Lett. 2006 Sep 1;16(17):4668-73. DMIH5CD RU https://pubmed.ncbi.nlm.nih.gov/16766182 DMIH5CD DI DMIH5CD DMIH5CD DN Ac-Tyr-D-Phe-Arg-2-Nal-NHCH3 DMIH5CD MI TTD0CIQ DMIH5CD MN Melanocortin receptor 4 (MC4R) DMIH5CD MT DTT DMIH5CD MA Inhibitor DMIH5CD RN Design and synthesis of potent and selective 1,3,4-trisubstituted-2-oxopiperazine based melanocortin-4 receptor agonists. Bioorg Med Chem Lett. 2006 Sep 1;16(17):4668-73. DMIH5CD RU https://pubmed.ncbi.nlm.nih.gov/16766182 DM7ZWRN DI DM7ZWRN DM7ZWRN DN ACU-0101979 DM7ZWRN MI TTE4KHA DM7ZWRN MN Amyloid beta A4 protein (APP) DM7ZWRN MT DTT DM7ZWRN RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2402). DM7ZWRN RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2402 DMR2MUG DI DMR2MUG DMR2MUG DN ACULEACIN A DMR2MUG MI TTZMS1L DMR2MUG MN Fungal Papulacandin B resistance protein 1 (Fung FKS1) DMR2MUG MT DTT DMR2MUG MA Inhibitor DMR2MUG RN Synthesis, anti-fungal and 1,3--D-glucan synthase inhibitory activities of caffeic and quinic acid derivatives. Bioorg Med Chem. 2010 Oct 1;18(19):7009-14. DMR2MUG RU https://pubmed.ncbi.nlm.nih.gov/20813534 DMMQKCV DI DMMQKCV DMMQKCV DN Acurea DMMQKCV MI TTZHY6R DMMQKCV MN Glycogen phosphorylase muscle form (GP) DMMQKCV MT DTT DMMQKCV MA Inhibitor DMMQKCV RN Binding of N-acetyl-N '-beta-D-glucopyranosyl urea and N-benzoyl-N '-beta-D-glucopyranosyl urea to glycogen phosphorylase b: kinetic and crystallographic studies. Eur J Biochem. 2002 Mar;269(6):1684-96. DMMQKCV RU https://pubmed.ncbi.nlm.nih.gov/11895439 DMWOYCZ DI DMWOYCZ DMWOYCZ DN Ac-VEID-CHO DMWOYCZ MI TTKW4ML DMWOYCZ MN Caspase 6 messenger RNA (CASP6 mRNA) DMWOYCZ MT DTT DMWOYCZ MA Inhibitor DMWOYCZ RN Synthesis and in vitro evaluation of sulfonamide isatin Michael acceptors as small molecule inhibitors of caspase-6. J Med Chem. 2009 Apr 23;52(8):2188-91. DMWOYCZ RU https://pubmed.ncbi.nlm.nih.gov/19326941 DML7Z1H DI DML7Z1H DML7Z1H DN ACVR2B DML7Z1H MI TTLFRKS DML7Z1H MN Activin receptor type IIB (ACVR2B) DML7Z1H MT DTT DML7Z1H MA Antagonist DML7Z1H RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1792). DML7Z1H RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1792 DMO0W9V DI DMO0W9V DMO0W9V DN Ac-VTHRLAGLLSRSGGVVKNNFVPTDVGPFAF-NH2 DMO0W9V MI TTVSFJW DMO0W9V MN Calcitonin gene-related peptide 1 (CALCA) DMO0W9V MT DTT DMO0W9V MA Inhibitor DMO0W9V RN Identification of potent, selective, and metabolically stable peptide antagonists to the calcitonin gene-related peptide (CGRP) receptor. J Med Chem. 2008 Dec 25;51(24):7889-97. DMO0W9V RU https://pubmed.ncbi.nlm.nih.gov/19053766 DMWJ2M5 DI DMWJ2M5 DMWJ2M5 DN Ac-VTHRLAGLLSRSGGVVRKNFVPTDVGPFAF-NH2 DMWJ2M5 MI TTVSFJW DMWJ2M5 MN Calcitonin gene-related peptide 1 (CALCA) DMWJ2M5 MT DTT DMWJ2M5 MA Inhibitor DMWJ2M5 RN Identification of potent, selective, and metabolically stable peptide antagonists to the calcitonin gene-related peptide (CGRP) receptor. J Med Chem. 2008 Dec 25;51(24):7889-97. DMWJ2M5 RU https://pubmed.ncbi.nlm.nih.gov/19053766 DMP89K4 DI DMP89K4 DMP89K4 DN Ac-w-F-F-N-Y-Y-W DMP89K4 MI TTKRD0G DMP89K4 MN Endothelin A receptor (EDNRA) DMP89K4 MT DTT DMP89K4 MA Inhibitor DMP89K4 RN Res-701-1, synthesis and a reevaluation of its effects on the endothelin receptors, Bioorg. Med. Chem. Lett. 5(6):621-626 (1995). DMP89K4 RU http://www.sciencedirect.com/science/article/pii/0960894X95000847 DMP89K4 DI DMP89K4 DMP89K4 DN Ac-w-F-F-N-Y-Y-W DMP89K4 MI TT3ZTGU DMP89K4 MN Endothelin B receptor (EDNRB) DMP89K4 MT DTT DMP89K4 MA Inhibitor DMP89K4 RN Res-701-1, synthesis and a reevaluation of its effects on the endothelin receptors, Bioorg. Med. Chem. Lett. 5(6):621-626 (1995). DMP89K4 RU http://www.sciencedirect.com/science/article/pii/0960894X95000847 DM7J9O6 DI DM7J9O6 DM7J9O6 DN Ac-WKY-NH2 DM7J9O6 MI TTW5UDX DM7J9O6 MN Urotensin II receptor (UTS2R) DM7J9O6 MT DTT DM7J9O6 MA Inhibitor DM7J9O6 RN Urotensin-II receptor modulators as potential drugs. J Med Chem. 2010 Apr 8;53(7):2695-708. DM7J9O6 RU https://pubmed.ncbi.nlm.nih.gov/20043680 DM9W21L DI DM9W21L DM9W21L DN Ac-WVEHRLKGELSRKGGVV[hArg]KNFVPTDVGPFAF-NH2 DM9W21L MI TTVSFJW DM9W21L MN Calcitonin gene-related peptide 1 (CALCA) DM9W21L MT DTT DM9W21L MA Inhibitor DM9W21L RN Identification of potent, selective, and metabolically stable peptide antagonists to the calcitonin gene-related peptide (CGRP) receptor. J Med Chem. 2008 Dec 25;51(24):7889-97. DM9W21L RU https://pubmed.ncbi.nlm.nih.gov/19053766 DMJU4AM DI DMJU4AM DMJU4AM DN Ac-WVTH[Cit]LAGLLS[Cit]SGGVVRKNFVPTDVGPFAF-NH2 DMJU4AM MI TTVSFJW DMJU4AM MN Calcitonin gene-related peptide 1 (CALCA) DMJU4AM MT DTT DMJU4AM MA Inhibitor DMJU4AM RN Identification of potent, selective, and metabolically stable peptide antagonists to the calcitonin gene-related peptide (CGRP) receptor. J Med Chem. 2008 Dec 25;51(24):7889-97. DMJU4AM RU https://pubmed.ncbi.nlm.nih.gov/19053766 DMR1N53 DI DMR1N53 DMR1N53 DN Ac-WVTH[Cit]LAGLLSRSGGVVRKNFVPTDVGPFAF-NH2 DMR1N53 MI TTVSFJW DMR1N53 MN Calcitonin gene-related peptide 1 (CALCA) DMR1N53 MT DTT DMR1N53 MA Inhibitor DMR1N53 RN Identification of potent, selective, and metabolically stable peptide antagonists to the calcitonin gene-related peptide (CGRP) receptor. J Med Chem. 2008 Dec 25;51(24):7889-97. DMR1N53 RU https://pubmed.ncbi.nlm.nih.gov/19053766 DM19NMF DI DM19NMF DM19NMF DN Ac-WVTH[hArg]LAGLLS[hArg]SGGVVRKNFVPTDVGPFAF-NH2 DM19NMF MI TTVSFJW DM19NMF MN Calcitonin gene-related peptide 1 (CALCA) DM19NMF MT DTT DM19NMF MA Inhibitor DM19NMF RN Identification of potent, selective, and metabolically stable peptide antagonists to the calcitonin gene-related peptide (CGRP) receptor. J Med Chem. 2008 Dec 25;51(24):7889-97. DM19NMF RU https://pubmed.ncbi.nlm.nih.gov/19053766 DM3BUP6 DI DM3BUP6 DM3BUP6 DN Ac-WVTHQLAGLLSQSGGVVRKNFVPTDVGPFAF-NH2 DM3BUP6 MI TTVSFJW DM3BUP6 MN Calcitonin gene-related peptide 1 (CALCA) DM3BUP6 MT DTT DM3BUP6 MA Inhibitor DM3BUP6 RN Identification of potent, selective, and metabolically stable peptide antagonists to the calcitonin gene-related peptide (CGRP) receptor. J Med Chem. 2008 Dec 25;51(24):7889-97. DM3BUP6 RU https://pubmed.ncbi.nlm.nih.gov/19053766 DMKO982 DI DMKO982 DMKO982 DN Ac-WVTHRLAGLLS[Cit]SGGVVRKNFVPTDVGPFAF-NH2 DMKO982 MI TTVSFJW DMKO982 MN Calcitonin gene-related peptide 1 (CALCA) DMKO982 MT DTT DMKO982 MA Inhibitor DMKO982 RN Identification of potent, selective, and metabolically stable peptide antagonists to the calcitonin gene-related peptide (CGRP) receptor. J Med Chem. 2008 Dec 25;51(24):7889-97. DMKO982 RU https://pubmed.ncbi.nlm.nih.gov/19053766 DMSMVK4 DI DMSMVK4 DMSMVK4 DN Ac-WVTHRLAGLLSRSGGVVRKNFVPTDVGPFAF-NH2 DMSMVK4 MI TTVSFJW DMSMVK4 MN Calcitonin gene-related peptide 1 (CALCA) DMSMVK4 MT DTT DMSMVK4 MA Inhibitor DMSMVK4 RN Identification of potent, selective, and metabolically stable peptide antagonists to the calcitonin gene-related peptide (CGRP) receptor. J Med Chem. 2008 Dec 25;51(24):7889-97. DMSMVK4 RU https://pubmed.ncbi.nlm.nih.gov/19053766 DMAVPXL DI DMAVPXL DMAVPXL DN Ac-YCit[CEHdFRWC]-NH2 DMAVPXL MI TT0MV2T DMAVPXL MN Melanocortin receptor 1 (MC1R) DMAVPXL MT DTT DMAVPXL MA Inhibitor DMAVPXL RN Discovery of a beta-MSH-derived MC-4R selective agonist. J Med Chem. 2005 May 5;48(9):3095-8. DMAVPXL RU https://pubmed.ncbi.nlm.nih.gov/15857110 DMAVPXL DI DMAVPXL DMAVPXL DN Ac-YCit[CEHdFRWC]-NH2 DMAVPXL MI TTNI91K DMAVPXL MN Melanocortin receptor 3 (MC3R) DMAVPXL MT DTT DMAVPXL MA Inhibitor DMAVPXL RN Discovery of a beta-MSH-derived MC-4R selective agonist. J Med Chem. 2005 May 5;48(9):3095-8. DMAVPXL RU https://pubmed.ncbi.nlm.nih.gov/15857110 DMAVPXL DI DMAVPXL DMAVPXL DN Ac-YCit[CEHdFRWC]-NH2 DMAVPXL MI TTD0CIQ DMAVPXL MN Melanocortin receptor 4 (MC4R) DMAVPXL MT DTT DMAVPXL MA Inhibitor DMAVPXL RN Discovery of a beta-MSH-derived MC-4R selective agonist. J Med Chem. 2005 May 5;48(9):3095-8. DMAVPXL RU https://pubmed.ncbi.nlm.nih.gov/15857110 DMC0TU5 DI DMC0TU5 DMC0TU5 DN Ac-YGGFL-NH2 DMC0TU5 MI TTKWM86 DMC0TU5 MN Opioid receptor mu (MOP) DMC0TU5 MT DTT DMC0TU5 MA Inhibitor DMC0TU5 RN Internalisation of the mu-opioid receptor by endomorphin-1 and leu-enkephalin is dependant on aromatic amino acid residues. Bioorg Med Chem. 2008 Apr 15;16(8):4341-6. DMC0TU5 RU https://pubmed.ncbi.nlm.nih.gov/18329886 DM5SJX8 DI DM5SJX8 DM5SJX8 DN Ac-YK[CEHdFRWC]-NH2 DM5SJX8 MI TT0MV2T DM5SJX8 MN Melanocortin receptor 1 (MC1R) DM5SJX8 MT DTT DM5SJX8 MA Inhibitor DM5SJX8 RN Discovery of a beta-MSH-derived MC-4R selective agonist. J Med Chem. 2005 May 5;48(9):3095-8. DM5SJX8 RU https://pubmed.ncbi.nlm.nih.gov/15857110 DM5SJX8 DI DM5SJX8 DM5SJX8 DN Ac-YK[CEHdFRWC]-NH2 DM5SJX8 MI TTNI91K DM5SJX8 MN Melanocortin receptor 3 (MC3R) DM5SJX8 MT DTT DM5SJX8 MA Inhibitor DM5SJX8 RN Discovery of a beta-MSH-derived MC-4R selective agonist. J Med Chem. 2005 May 5;48(9):3095-8. DM5SJX8 RU https://pubmed.ncbi.nlm.nih.gov/15857110 DM5SJX8 DI DM5SJX8 DM5SJX8 DN Ac-YK[CEHdFRWC]-NH2 DM5SJX8 MI TTD0CIQ DM5SJX8 MN Melanocortin receptor 4 (MC4R) DM5SJX8 MT DTT DM5SJX8 MA Inhibitor DM5SJX8 RN Discovery of a beta-MSH-derived MC-4R selective agonist. J Med Chem. 2005 May 5;48(9):3095-8. DM5SJX8 RU https://pubmed.ncbi.nlm.nih.gov/15857110 DMIZ5VO DI DMIZ5VO DMIZ5VO DN Acylated Ceftazidime DMIZ5VO MI TTHI19T DMIZ5VO MN Staphylococcus Beta-lactamase (Stap-coc blaZ) DMIZ5VO MT DTT DMIZ5VO MA Inhibitor DMIZ5VO RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMIZ5VO RU https://pubmed.ncbi.nlm.nih.gov/17139284 DM4CYKE DI DM4CYKE DM4CYKE DN Acylureido penicillin mezlocillin DM4CYKE MI TT85JMW DM4CYKE MN Bacterial Penicillin binding protein 3 (Bact mrcA) DM4CYKE MT DTT DM4CYKE MA Binder DM4CYKE RN Microbiology, pharmacology, and clinical use of mezlocillin sodium. Pharmacotherapy. 1982 Nov-Dec;2(6):300-12. DM4CYKE RU https://pubmed.ncbi.nlm.nih.gov/6220263 DMJK8QZ DI DMJK8QZ DMJK8QZ DN Ac-YR[CE(1-Me-H)dFRWC]-NH2 DMJK8QZ MI TTD0CIQ DMJK8QZ MN Melanocortin receptor 4 (MC4R) DMJK8QZ MT DTT DMJK8QZ MA Inhibitor DMJK8QZ RN Discovery of a beta-MSH-derived MC-4R selective agonist. J Med Chem. 2005 May 5;48(9):3095-8. DMJK8QZ RU https://pubmed.ncbi.nlm.nih.gov/15857110 DMVQ4KG DI DMVQ4KG DMVQ4KG DN Ac-YR[CEH(d-2alpha-Nal)RWC]-NH2 DMVQ4KG MI TTEOSZT DMVQ4KG MN Melanocortin receptor (MCR) DMVQ4KG MT DTT DMVQ4KG MA Inhibitor DMVQ4KG RN Discovery of a beta-MSH-derived MC-4R selective agonist. J Med Chem. 2005 May 5;48(9):3095-8. DMVQ4KG RU https://pubmed.ncbi.nlm.nih.gov/15857110 DMVQ4KG DI DMVQ4KG DMVQ4KG DN Ac-YR[CEH(d-2alpha-Nal)RWC]-NH2 DMVQ4KG MI TT0MV2T DMVQ4KG MN Melanocortin receptor 1 (MC1R) DMVQ4KG MT DTT DMVQ4KG MA Inhibitor DMVQ4KG RN Discovery of a beta-MSH-derived MC-4R selective agonist. J Med Chem. 2005 May 5;48(9):3095-8. DMVQ4KG RU https://pubmed.ncbi.nlm.nih.gov/15857110 DMVQ4KG DI DMVQ4KG DMVQ4KG DN Ac-YR[CEH(d-2alpha-Nal)RWC]-NH2 DMVQ4KG MI TTNI91K DMVQ4KG MN Melanocortin receptor 3 (MC3R) DMVQ4KG MT DTT DMVQ4KG MA Inhibitor DMVQ4KG RN Discovery of a beta-MSH-derived MC-4R selective agonist. J Med Chem. 2005 May 5;48(9):3095-8. DMVQ4KG RU https://pubmed.ncbi.nlm.nih.gov/15857110 DMVQ4KG DI DMVQ4KG DMVQ4KG DN Ac-YR[CEH(d-2alpha-Nal)RWC]-NH2 DMVQ4KG MI TTD0CIQ DMVQ4KG MN Melanocortin receptor 4 (MC4R) DMVQ4KG MT DTT DMVQ4KG MA Inhibitor DMVQ4KG RN Discovery of a beta-MSH-derived MC-4R selective agonist. J Med Chem. 2005 May 5;48(9):3095-8. DMVQ4KG RU https://pubmed.ncbi.nlm.nih.gov/15857110 DM25JXM DI DM25JXM DM25JXM DN Ac-YR[CEH(pCl-dF)RWC]-NH2 DM25JXM MI TTEOSZT DM25JXM MN Melanocortin receptor (MCR) DM25JXM MT DTT DM25JXM MA Inhibitor DM25JXM RN Discovery of a beta-MSH-derived MC-4R selective agonist. J Med Chem. 2005 May 5;48(9):3095-8. DM25JXM RU https://pubmed.ncbi.nlm.nih.gov/15857110 DM25JXM DI DM25JXM DM25JXM DN Ac-YR[CEH(pCl-dF)RWC]-NH2 DM25JXM MI TT0MV2T DM25JXM MN Melanocortin receptor 1 (MC1R) DM25JXM MT DTT DM25JXM MA Inhibitor DM25JXM RN Discovery of a beta-MSH-derived MC-4R selective agonist. J Med Chem. 2005 May 5;48(9):3095-8. DM25JXM RU https://pubmed.ncbi.nlm.nih.gov/15857110 DM25JXM DI DM25JXM DM25JXM DN Ac-YR[CEH(pCl-dF)RWC]-NH2 DM25JXM MI TTNI91K DM25JXM MN Melanocortin receptor 3 (MC3R) DM25JXM MT DTT DM25JXM MA Inhibitor DM25JXM RN Discovery of a beta-MSH-derived MC-4R selective agonist. J Med Chem. 2005 May 5;48(9):3095-8. DM25JXM RU https://pubmed.ncbi.nlm.nih.gov/15857110 DM25JXM DI DM25JXM DM25JXM DN Ac-YR[CEH(pCl-dF)RWC]-NH2 DM25JXM MI TTD0CIQ DM25JXM MN Melanocortin receptor 4 (MC4R) DM25JXM MT DTT DM25JXM MA Inhibitor DM25JXM RN Discovery of a beta-MSH-derived MC-4R selective agonist. J Med Chem. 2005 May 5;48(9):3095-8. DM25JXM RU https://pubmed.ncbi.nlm.nih.gov/15857110 DMXCF9T DI DMXCF9T DMXCF9T DN Ac-YR[CEH(pF-dF)RWC]-NH2 DMXCF9T MI TTEOSZT DMXCF9T MN Melanocortin receptor (MCR) DMXCF9T MT DTT DMXCF9T MA Inhibitor DMXCF9T RN Discovery of a beta-MSH-derived MC-4R selective agonist. J Med Chem. 2005 May 5;48(9):3095-8. DMXCF9T RU https://pubmed.ncbi.nlm.nih.gov/15857110 DMXCF9T DI DMXCF9T DMXCF9T DN Ac-YR[CEH(pF-dF)RWC]-NH2 DMXCF9T MI TT0MV2T DMXCF9T MN Melanocortin receptor 1 (MC1R) DMXCF9T MT DTT DMXCF9T MA Inhibitor DMXCF9T RN Discovery of a beta-MSH-derived MC-4R selective agonist. J Med Chem. 2005 May 5;48(9):3095-8. DMXCF9T RU https://pubmed.ncbi.nlm.nih.gov/15857110 DMXCF9T DI DMXCF9T DMXCF9T DN Ac-YR[CEH(pF-dF)RWC]-NH2 DMXCF9T MI TTNI91K DMXCF9T MN Melanocortin receptor 3 (MC3R) DMXCF9T MT DTT DMXCF9T MA Inhibitor DMXCF9T RN Discovery of a beta-MSH-derived MC-4R selective agonist. J Med Chem. 2005 May 5;48(9):3095-8. DMXCF9T RU https://pubmed.ncbi.nlm.nih.gov/15857110 DMXCF9T DI DMXCF9T DMXCF9T DN Ac-YR[CEH(pF-dF)RWC]-NH2 DMXCF9T MI TTD0CIQ DMXCF9T MN Melanocortin receptor 4 (MC4R) DMXCF9T MT DTT DMXCF9T MA Inhibitor DMXCF9T RN Discovery of a beta-MSH-derived MC-4R selective agonist. J Med Chem. 2005 May 5;48(9):3095-8. DMXCF9T RU https://pubmed.ncbi.nlm.nih.gov/15857110 DMBMY73 DI DMBMY73 DMBMY73 DN Ac-YR[CEHdFRWC]-NH2 DMBMY73 MI TT0MV2T DMBMY73 MN Melanocortin receptor 1 (MC1R) DMBMY73 MT DTT DMBMY73 MA Inhibitor DMBMY73 RN Discovery of a beta-MSH-derived MC-4R selective agonist. J Med Chem. 2005 May 5;48(9):3095-8. DMBMY73 RU https://pubmed.ncbi.nlm.nih.gov/15857110 DMBMY73 DI DMBMY73 DMBMY73 DN Ac-YR[CEHdFRWC]-NH2 DMBMY73 MI TTNI91K DMBMY73 MN Melanocortin receptor 3 (MC3R) DMBMY73 MT DTT DMBMY73 MA Inhibitor DMBMY73 RN Discovery of a beta-MSH-derived MC-4R selective agonist. J Med Chem. 2005 May 5;48(9):3095-8. DMBMY73 RU https://pubmed.ncbi.nlm.nih.gov/15857110 DMBMY73 DI DMBMY73 DMBMY73 DN Ac-YR[CEHdFRWC]-NH2 DMBMY73 MI TTD0CIQ DMBMY73 MN Melanocortin receptor 4 (MC4R) DMBMY73 MT DTT DMBMY73 MA Inhibitor DMBMY73 RN Discovery of a beta-MSH-derived MC-4R selective agonist. J Med Chem. 2005 May 5;48(9):3095-8. DMBMY73 RU https://pubmed.ncbi.nlm.nih.gov/15857110 DMDO468 DI DMDO468 DMDO468 DN Ac-YR[CEHdFRWC]SPPKD-NH2 DMDO468 MI TT0MV2T DMDO468 MN Melanocortin receptor 1 (MC1R) DMDO468 MT DTT DMDO468 MA Inhibitor DMDO468 RN Discovery of a beta-MSH-derived MC-4R selective agonist. J Med Chem. 2005 May 5;48(9):3095-8. DMDO468 RU https://pubmed.ncbi.nlm.nih.gov/15857110 DMDO468 DI DMDO468 DMDO468 DN Ac-YR[CEHdFRWC]SPPKD-NH2 DMDO468 MI TTNI91K DMDO468 MN Melanocortin receptor 3 (MC3R) DMDO468 MT DTT DMDO468 MA Inhibitor DMDO468 RN Discovery of a beta-MSH-derived MC-4R selective agonist. J Med Chem. 2005 May 5;48(9):3095-8. DMDO468 RU https://pubmed.ncbi.nlm.nih.gov/15857110 DMDO468 DI DMDO468 DMDO468 DN Ac-YR[CEHdFRWC]SPPKD-NH2 DMDO468 MI TTD0CIQ DMDO468 MN Melanocortin receptor 4 (MC4R) DMDO468 MT DTT DMDO468 MA Inhibitor DMDO468 RN Discovery of a beta-MSH-derived MC-4R selective agonist. J Med Chem. 2005 May 5;48(9):3095-8. DMDO468 RU https://pubmed.ncbi.nlm.nih.gov/15857110 DMH0EAI DI DMH0EAI DMH0EAI DN Ac-YR[CEHFRWC]-NH2 DMH0EAI MI TT0MV2T DMH0EAI MN Melanocortin receptor 1 (MC1R) DMH0EAI MT DTT DMH0EAI MA Inhibitor DMH0EAI RN Discovery of a beta-MSH-derived MC-4R selective agonist. J Med Chem. 2005 May 5;48(9):3095-8. DMH0EAI RU https://pubmed.ncbi.nlm.nih.gov/15857110 DMH0EAI DI DMH0EAI DMH0EAI DN Ac-YR[CEHFRWC]-NH2 DMH0EAI MI TTD0CIQ DMH0EAI MN Melanocortin receptor 4 (MC4R) DMH0EAI MT DTT DMH0EAI MA Inhibitor DMH0EAI RN Discovery of a beta-MSH-derived MC-4R selective agonist. J Med Chem. 2005 May 5;48(9):3095-8. DMH0EAI RU https://pubmed.ncbi.nlm.nih.gov/15857110 DMWJ8UR DI DMWJ8UR DMWJ8UR DN Ac-YRC(Me)*EHdFRWC(Me)NH2 DMWJ8UR MI TTEOSZT DMWJ8UR MN Melanocortin receptor (MCR) DMWJ8UR MT DTT DMWJ8UR MA Inhibitor DMWJ8UR RN Discovery of a beta-MSH-derived MC-4R selective agonist. J Med Chem. 2005 May 5;48(9):3095-8. DMWJ8UR RU https://pubmed.ncbi.nlm.nih.gov/15857110 DMWJ8UR DI DMWJ8UR DMWJ8UR DN Ac-YRC(Me)*EHdFRWC(Me)NH2 DMWJ8UR MI TT0MV2T DMWJ8UR MN Melanocortin receptor 1 (MC1R) DMWJ8UR MT DTT DMWJ8UR MA Inhibitor DMWJ8UR RN Discovery of a beta-MSH-derived MC-4R selective agonist. J Med Chem. 2005 May 5;48(9):3095-8. DMWJ8UR RU https://pubmed.ncbi.nlm.nih.gov/15857110 DMWJ8UR DI DMWJ8UR DMWJ8UR DN Ac-YRC(Me)*EHdFRWC(Me)NH2 DMWJ8UR MI TTNI91K DMWJ8UR MN Melanocortin receptor 3 (MC3R) DMWJ8UR MT DTT DMWJ8UR MA Inhibitor DMWJ8UR RN Discovery of a beta-MSH-derived MC-4R selective agonist. J Med Chem. 2005 May 5;48(9):3095-8. DMWJ8UR RU https://pubmed.ncbi.nlm.nih.gov/15857110 DMWJ8UR DI DMWJ8UR DMWJ8UR DN Ac-YRC(Me)*EHdFRWC(Me)NH2 DMWJ8UR MI TTD0CIQ DMWJ8UR MN Melanocortin receptor 4 (MC4R) DMWJ8UR MT DTT DMWJ8UR MA Inhibitor DMWJ8UR RN Discovery of a beta-MSH-derived MC-4R selective agonist. J Med Chem. 2005 May 5;48(9):3095-8. DMWJ8UR RU https://pubmed.ncbi.nlm.nih.gov/15857110 DMN2UKC DI DMN2UKC DMN2UKC DN Ac-YRMEHdFRWG-NH2 DMN2UKC MI TTEOSZT DMN2UKC MN Melanocortin receptor (MCR) DMN2UKC MT DTT DMN2UKC MA Inhibitor DMN2UKC RN Discovery of a beta-MSH-derived MC-4R selective agonist. J Med Chem. 2005 May 5;48(9):3095-8. DMN2UKC RU https://pubmed.ncbi.nlm.nih.gov/15857110 DMN2UKC DI DMN2UKC DMN2UKC DN Ac-YRMEHdFRWG-NH2 DMN2UKC MI TT0MV2T DMN2UKC MN Melanocortin receptor 1 (MC1R) DMN2UKC MT DTT DMN2UKC MA Inhibitor DMN2UKC RN Discovery of a beta-MSH-derived MC-4R selective agonist. J Med Chem. 2005 May 5;48(9):3095-8. DMN2UKC RU https://pubmed.ncbi.nlm.nih.gov/15857110 DMN2UKC DI DMN2UKC DMN2UKC DN Ac-YRMEHdFRWG-NH2 DMN2UKC MI TTNI91K DMN2UKC MN Melanocortin receptor 3 (MC3R) DMN2UKC MT DTT DMN2UKC MA Inhibitor DMN2UKC RN Discovery of a beta-MSH-derived MC-4R selective agonist. J Med Chem. 2005 May 5;48(9):3095-8. DMN2UKC RU https://pubmed.ncbi.nlm.nih.gov/15857110 DMN2UKC DI DMN2UKC DMN2UKC DN Ac-YRMEHdFRWG-NH2 DMN2UKC MI TTD0CIQ DMN2UKC MN Melanocortin receptor 4 (MC4R) DMN2UKC MT DTT DMN2UKC MA Inhibitor DMN2UKC RN Discovery of a beta-MSH-derived MC-4R selective agonist. J Med Chem. 2005 May 5;48(9):3095-8. DMN2UKC RU https://pubmed.ncbi.nlm.nih.gov/15857110 DMDH5B3 DI DMDH5B3 DMDH5B3 DN Ac-YRMEHdFRWGSPPKD-NH2 DMDH5B3 MI TTEOSZT DMDH5B3 MN Melanocortin receptor (MCR) DMDH5B3 MT DTT DMDH5B3 MA Inhibitor DMDH5B3 RN Discovery of a beta-MSH-derived MC-4R selective agonist. J Med Chem. 2005 May 5;48(9):3095-8. DMDH5B3 RU https://pubmed.ncbi.nlm.nih.gov/15857110 DMDH5B3 DI DMDH5B3 DMDH5B3 DN Ac-YRMEHdFRWGSPPKD-NH2 DMDH5B3 MI TT0MV2T DMDH5B3 MN Melanocortin receptor 1 (MC1R) DMDH5B3 MT DTT DMDH5B3 MA Inhibitor DMDH5B3 RN Discovery of a beta-MSH-derived MC-4R selective agonist. J Med Chem. 2005 May 5;48(9):3095-8. DMDH5B3 RU https://pubmed.ncbi.nlm.nih.gov/15857110 DMDH5B3 DI DMDH5B3 DMDH5B3 DN Ac-YRMEHdFRWGSPPKD-NH2 DMDH5B3 MI TTNI91K DMDH5B3 MN Melanocortin receptor 3 (MC3R) DMDH5B3 MT DTT DMDH5B3 MA Inhibitor DMDH5B3 RN Discovery of a beta-MSH-derived MC-4R selective agonist. J Med Chem. 2005 May 5;48(9):3095-8. DMDH5B3 RU https://pubmed.ncbi.nlm.nih.gov/15857110 DMDH5B3 DI DMDH5B3 DMDH5B3 DN Ac-YRMEHdFRWGSPPKD-NH2 DMDH5B3 MI TTD0CIQ DMDH5B3 MN Melanocortin receptor 4 (MC4R) DMDH5B3 MT DTT DMDH5B3 MA Inhibitor DMDH5B3 RN Discovery of a beta-MSH-derived MC-4R selective agonist. J Med Chem. 2005 May 5;48(9):3095-8. DMDH5B3 RU https://pubmed.ncbi.nlm.nih.gov/15857110 DM23QND DI DM23QND DM23QND DN AD-0802 DM23QND MI TTE4KHA DM23QND MN Amyloid beta A4 protein (APP) DM23QND MT DTT DM23QND RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2402). DM23QND RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2402 DMYLA29 DI DMYLA29 DMYLA29 DN AD10-1025 DMYLA29 MI TTCBFJO DMYLA29 MN Insulin receptor (INSR) DMYLA29 MT DTT DMYLA29 MA Agonist DMYLA29 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1800). DMYLA29 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1800 DMJMCDP DI DMJMCDP DMJMCDP DN AD-412 DMJMCDP MI TTT7PJU DMJMCDP MN Janus kinase 3 (JAK-3) DMJMCDP MT DTT DMJMCDP MA Inhibitor DMJMCDP RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2049). DMJMCDP RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2049 DM5WV13 DI DM5WV13 DM5WV13 DN AD-5061 DM5WV13 MI TTJ584C DM5WV13 MN Peroxisome proliferator-activated receptor alpha (PPARA) DM5WV13 MT DTT DM5WV13 MA Agonist DM5WV13 RN A novel oxyiminoalkanoic acid derivative, TAK-559, activates human peroxisome proliferator-activated receptor subtypes. Eur J Pharmacol. 2004 Jul 8;495(1):17-26. DM5WV13 RU https://pubmed.ncbi.nlm.nih.gov/15219816 DM5WV13 DI DM5WV13 DM5WV13 DN AD-5061 DM5WV13 MI TTT2SVW DM5WV13 MN PPAR-gamma messenger RNA (PPARG mRNA) DM5WV13 MT DTT DM5WV13 MA Agonist DM5WV13 RN A novel oxyiminoalkanoic acid derivative, TAK-559, activates human peroxisome proliferator-activated receptor subtypes. Eur J Pharmacol. 2004 Jul 8;495(1):17-26. DM5WV13 RU https://pubmed.ncbi.nlm.nih.gov/15219816 DMV48L3 DI DMV48L3 DMV48L3 DN AD5-10 DMV48L3 MI TTW20TU DMV48L3 MN TRAIL receptor 2 (TRAIL-R2) DMV48L3 MT DTT DMV48L3 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1880). DMV48L3 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1880 DMQW612 DI DMQW612 DMQW612 DN Ad5f35-LMPd1-2-transduced autologous dendritic cells DMQW612 MI TT0BI4Q DMQW612 MN Epstein-Barr virus Latent membrane protein 1 (EBV LMP1) DMQW612 MT DTT DMQW612 RN CA patent application no. 876139, Nanotherapeutics for drug targeting. DMQW612 RU http://www.google.com/patents/CA2876139A1?cl=en DMQW612 DI DMQW612 DMQW612 DN Ad5f35-LMPd1-2-transduced autologous dendritic cells DMQW612 MI TTBK351 DMQW612 MN Epstein-Barr virus Latent membrane protein 2 (EBV LMP2) DMQW612 MT DTT DMQW612 RN CA patent application no. 876139, Nanotherapeutics for drug targeting. DMQW612 RU http://www.google.com/patents/CA2876139A1?cl=en DMKDRVZ DI DMKDRVZ DMKDRVZ DN Adamant-1-ylcarbamic Acid Biphenyl-3-yl Ester DMKDRVZ MI TTDP1UC DMKDRVZ MN Fatty acid amide hydrolase (FAAH) DMKDRVZ MT DTT DMKDRVZ MA Inhibitor DMKDRVZ RN Synthesis and quantitative structure-activity relationship of fatty acid amide hydrolase inhibitors: modulation at the N-portion of biphenyl-3-yl a... J Med Chem. 2008 Jun 26;51(12):3487-98. DMKDRVZ RU https://pubmed.ncbi.nlm.nih.gov/18507372 DM4S279 DI DM4S279 DM4S279 DN Adamantan-1-yl-(4-ethyl-piperazin-1-yl)-methanone DM4S279 MI TTN7BL9 DM4S279 MN Corticosteroid 11-beta-dehydrogenase 1 (HSD11B1) DM4S279 MT DTT DM4S279 MA Inhibitor DM4S279 RN Discovery and biological evaluation of adamantyl amide 11beta-HSD1 inhibitors. Bioorg Med Chem Lett. 2007 May 15;17(10):2838-43. DM4S279 RU https://pubmed.ncbi.nlm.nih.gov/17350260 DM5K0EI DI DM5K0EI DM5K0EI DN Adamantan-1-yl-piperazin-1-yl-methanone DM5K0EI MI TTN7BL9 DM5K0EI MN Corticosteroid 11-beta-dehydrogenase 1 (HSD11B1) DM5K0EI MT DTT DM5K0EI MA Inhibitor DM5K0EI RN Discovery and biological evaluation of adamantyl amide 11beta-HSD1 inhibitors. Bioorg Med Chem Lett. 2007 May 15;17(10):2838-43. DM5K0EI RU https://pubmed.ncbi.nlm.nih.gov/17350260 DMTUL9J DI DMTUL9J DMTUL9J DN Adamantan-1-yl-piperidin-1-yl-methanone DMTUL9J MI TTN7BL9 DMTUL9J MN Corticosteroid 11-beta-dehydrogenase 1 (HSD11B1) DMTUL9J MT DTT DMTUL9J MA Inhibitor DMTUL9J RN Discovery and biological evaluation of adamantyl amide 11beta-HSD1 inhibitors. Bioorg Med Chem Lett. 2007 May 15;17(10):2838-43. DMTUL9J RU https://pubmed.ncbi.nlm.nih.gov/17350260 DMAEN9Y DI DMAEN9Y DMAEN9Y DN Adamantan-1-yl-pyrrolidin-1-yl-methanone DMAEN9Y MI TTN7BL9 DMAEN9Y MN Corticosteroid 11-beta-dehydrogenase 1 (HSD11B1) DMAEN9Y MT DTT DMAEN9Y MA Inhibitor DMAEN9Y RN Discovery and biological evaluation of adamantyl amide 11beta-HSD1 inhibitors. Bioorg Med Chem Lett. 2007 May 15;17(10):2838-43. DMAEN9Y RU https://pubmed.ncbi.nlm.nih.gov/17350260 DMBRAV5 DI DMBRAV5 DMBRAV5 DN Adamantan-2-yl-piperidin-1-yl-methanone DMBRAV5 MI TTN7BL9 DMBRAV5 MN Corticosteroid 11-beta-dehydrogenase 1 (HSD11B1) DMBRAV5 MT DTT DMBRAV5 MA Inhibitor DMBRAV5 RN Discovery and biological evaluation of adamantyl amide 11beta-HSD1 inhibitors. Bioorg Med Chem Lett. 2007 May 15;17(10):2838-43. DMBRAV5 RU https://pubmed.ncbi.nlm.nih.gov/17350260 DM1MAVU DI DM1MAVU DM1MAVU DN Ada-RYYRIK-NH2 DM1MAVU MI TTNT7K8 DM1MAVU MN Nociceptin receptor (OPRL1) DM1MAVU MT DTT DM1MAVU MA Inhibitor DM1MAVU RN Designed modification of partial agonist of ORL1 nociceptin receptor for conversion into highly potent antagonist. Bioorg Med Chem. 2008 Mar 1;16(5):2635-44. DM1MAVU RU https://pubmed.ncbi.nlm.nih.gov/18068993 DMJQM7H DI DMJQM7H DMJQM7H DN ADC-1012 DMJQM7H MI TT6H4QR DMJQM7H MN Interleukin 23 receptor (IL23R) DMJQM7H MT DTT DMJQM7H MA Antagonist DMJQM7H RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2293). DMJQM7H RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2293 DMV761D DI DMV761D DMV761D DN ADC-5510 DMV761D MI TTKWM86 DMV761D MN Opioid receptor mu (MOP) DMV761D MT DTT DMV761D MA Antagonist DMV761D RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 319). DMV761D RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=319 DM19KY6 DI DM19KY6 DM19KY6 DN ADC-7828 DM19KY6 MI TTPLTSQ DM19KY6 MN Neutrophil elastase (NE) DM19KY6 MT DTT DM19KY6 MA Inhibitor DM19KY6 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2358). DM19KY6 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2358 DMY6PMJ DI DMY6PMJ DMY6PMJ DN ADC-9971 DMY6PMJ MI TTQDMX5 DMY6PMJ MN Prostaglandin D2 receptor 2 (PTGDR2) DMY6PMJ MT DTT DMY6PMJ MA Antagonist DMY6PMJ RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 339). DMY6PMJ RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=339 DMZYJHV DI DMZYJHV DMZYJHV DN AdcAhxArg4Lys(biotin)-PEG-OMe DMZYJHV MI TTW4Y2M DMZYJHV MN cAMP protein kinase type II-beta (PRKAR2B) DMZYJHV MT DTT DMZYJHV MA Inhibitor DMZYJHV RN Liquid-phase synthesis of a pegylated adenosine-oligoarginine conjugate, cell-permeable inhibitor of cAMP-dependent protein kinase. Bioorg Med Chem Lett. 2003 Sep 15;13(18):3035-9. DMZYJHV RU https://pubmed.ncbi.nlm.nih.gov/12941328 DMZYJHV DI DMZYJHV DMZYJHV DN AdcAhxArg4Lys(biotin)-PEG-OMe DMZYJHV MI TTNAHEX DMZYJHV MN cAMP-dependent protein kinase A type I (PRKAR1A) DMZYJHV MT DTT DMZYJHV MA Inhibitor DMZYJHV RN Liquid-phase synthesis of a pegylated adenosine-oligoarginine conjugate, cell-permeable inhibitor of cAMP-dependent protein kinase. Bioorg Med Chem Lett. 2003 Sep 15;13(18):3035-9. DMZYJHV RU https://pubmed.ncbi.nlm.nih.gov/12941328 DMQ2C8X DI DMQ2C8X DMQ2C8X DN AdcAhxArg4Lys-PEGOMe DMQ2C8X MI TTW4Y2M DMQ2C8X MN cAMP protein kinase type II-beta (PRKAR2B) DMQ2C8X MT DTT DMQ2C8X MA Inhibitor DMQ2C8X RN Liquid-phase synthesis of a pegylated adenosine-oligoarginine conjugate, cell-permeable inhibitor of cAMP-dependent protein kinase. Bioorg Med Chem Lett. 2003 Sep 15;13(18):3035-9. DMQ2C8X RU https://pubmed.ncbi.nlm.nih.gov/12941328 DMQ2C8X DI DMQ2C8X DMQ2C8X DN AdcAhxArg4Lys-PEGOMe DMQ2C8X MI TTNAHEX DMQ2C8X MN cAMP-dependent protein kinase A type I (PRKAR1A) DMQ2C8X MT DTT DMQ2C8X MA Inhibitor DMQ2C8X RN Liquid-phase synthesis of a pegylated adenosine-oligoarginine conjugate, cell-permeable inhibitor of cAMP-dependent protein kinase. Bioorg Med Chem Lett. 2003 Sep 15;13(18):3035-9. DMQ2C8X RU https://pubmed.ncbi.nlm.nih.gov/12941328 DMSYMRJ DI DMSYMRJ DMSYMRJ DN AdcAhxArg4NH(CH2)6NH2 DMSYMRJ MI TTW4Y2M DMSYMRJ MN cAMP protein kinase type II-beta (PRKAR2B) DMSYMRJ MT DTT DMSYMRJ MA Inhibitor DMSYMRJ RN Liquid-phase synthesis of a pegylated adenosine-oligoarginine conjugate, cell-permeable inhibitor of cAMP-dependent protein kinase. Bioorg Med Chem Lett. 2003 Sep 15;13(18):3035-9. DMSYMRJ RU https://pubmed.ncbi.nlm.nih.gov/12941328 DMSYMRJ DI DMSYMRJ DMSYMRJ DN AdcAhxArg4NH(CH2)6NH2 DMSYMRJ MI TTNAHEX DMSYMRJ MN cAMP-dependent protein kinase A type I (PRKAR1A) DMSYMRJ MT DTT DMSYMRJ MA Inhibitor DMSYMRJ RN Liquid-phase synthesis of a pegylated adenosine-oligoarginine conjugate, cell-permeable inhibitor of cAMP-dependent protein kinase. Bioorg Med Chem Lett. 2003 Sep 15;13(18):3035-9. DMSYMRJ RU https://pubmed.ncbi.nlm.nih.gov/12941328 DM7J3K0 DI DM7J3K0 DM7J3K0 DN AdcAhxArg6 DM7J3K0 MI TTW4Y2M DM7J3K0 MN cAMP protein kinase type II-beta (PRKAR2B) DM7J3K0 MT DTT DM7J3K0 MA Inhibitor DM7J3K0 RN Liquid-phase synthesis of a pegylated adenosine-oligoarginine conjugate, cell-permeable inhibitor of cAMP-dependent protein kinase. Bioorg Med Chem Lett. 2003 Sep 15;13(18):3035-9. DM7J3K0 RU https://pubmed.ncbi.nlm.nih.gov/12941328 DM7J3K0 DI DM7J3K0 DM7J3K0 DN AdcAhxArg6 DM7J3K0 MI TTNAHEX DM7J3K0 MN cAMP-dependent protein kinase A type I (PRKAR1A) DM7J3K0 MT DTT DM7J3K0 MA Inhibitor DM7J3K0 RN Liquid-phase synthesis of a pegylated adenosine-oligoarginine conjugate, cell-permeable inhibitor of cAMP-dependent protein kinase. Bioorg Med Chem Lett. 2003 Sep 15;13(18):3035-9. DM7J3K0 RU https://pubmed.ncbi.nlm.nih.gov/12941328 DMV39AW DI DMV39AW DMV39AW DN ADENOPHOSTIN A DMV39AW MI TTC9IZL DMV39AW MN Inositol 1,4,5-trisphosphate receptor (ITPR) DMV39AW MT DTT DMV39AW MA Inhibitor DMV39AW RN Synthesis of adenophostin A analogues conjugating an aromatic group at the 5'-position as potent IP3 receptor ligands. J Med Chem. 2006 Sep 21;49(19):5750-8. DMV39AW RU https://pubmed.ncbi.nlm.nih.gov/16970399 DMFUHKP DI DMFUHKP DMFUHKP DN adenosine diphosphate DMFUHKP MI TTJ2HKA DMFUHKP MN Long transient receptor potential channel 4 (TRPM4) DMFUHKP MT DTT DMFUHKP MA Inhibitor (gating inhibitor) DMFUHKP RN Intracellular nucleotides and polyamines inhibit the Ca2+-activated cation channel TRPM4b. Pflugers Arch. 2004 Apr;448(1):70-5. DMFUHKP RU https://pubmed.ncbi.nlm.nih.gov/14758478 DMFUHKP DI DMFUHKP DMFUHKP DN adenosine diphosphate DMFUHKP MI TTA93TL DMFUHKP MN P2Y purinoceptor 1 (P2RY1) DMFUHKP MT DTT DMFUHKP MA Agonist DMFUHKP RN Quantitation of the P2Y(1) receptor with a high affinity radiolabeled antagonist. Mol Pharmacol. 2002 Nov;62(5):1249-57. DMFUHKP RU https://pubmed.ncbi.nlm.nih.gov/12391289 DMFUHKP DI DMFUHKP DMFUHKP DN adenosine diphosphate DMFUHKP MI TTZ1DT0 DMFUHKP MN P2Y purinoceptor 12 (P2RY12) DMFUHKP MT DTT DMFUHKP MA Agonist DMFUHKP RN P2Y12, a new platelet ADP receptor, target of clopidogrel. Semin Vasc Med. 2003 May;3(2):113-22. DMFUHKP RU https://pubmed.ncbi.nlm.nih.gov/15199474 DMFUHKP DI DMFUHKP DMFUHKP DN adenosine diphosphate DMFUHKP MI TT1FE3L DMFUHKP MN P2Y purinoceptor 13 (P2RY13) DMFUHKP MT DTT DMFUHKP MA Agonist DMFUHKP RN Pharmacological characterization of the human P2Y13 receptor. Mol Pharmacol. 2003 Jul;64(1):104-12. DMFUHKP RU https://pubmed.ncbi.nlm.nih.gov/12815166 DMFUHKP DI DMFUHKP DMFUHKP DN adenosine diphosphate DMFUHKP MI TTNVSKA DMFUHKP MN P2Y purinoceptor 6 (P2RY6) DMFUHKP MT DTT DMFUHKP MA Agonist DMFUHKP RN Cloning, functional expression and tissue distribution of the human P2Y6 receptor. Biochem Biophys Res Commun. 1996 May 15;222(2):303-8. DMFUHKP RU https://pubmed.ncbi.nlm.nih.gov/8670200 DMJZPSX DI DMJZPSX DMJZPSX DN Adenosine Monotungstate DMJZPSX MI TTMS54D DMJZPSX MN Fragile histidine triad protein (FHIT) DMJZPSX MT DTT DMJZPSX MA Inhibitor DMJZPSX RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMJZPSX RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMSOVFD DI DMSOVFD DMSOVFD DN adenosine-3'-5'-bisphosphate DMSOVFD MI TTA93TL DMSOVFD MN P2Y purinoceptor 1 (P2RY1) DMSOVFD MT DTT DMSOVFD MA Antagonist DMSOVFD RN Identification of competitive antagonists of the P2Y1 receptor. Mol Pharmacol. 1996 Nov;50(5):1323-9. DMSOVFD RU https://pubmed.ncbi.nlm.nih.gov/8913364 DM96LBV DI DM96LBV DM96LBV DN Adenosine-5-Diphosphoribose DM96LBV MI TTCNGJ5 DM96LBV MN Candida Elongation factor 2 (Candi EFT2) DM96LBV MT DTT DM96LBV MA Inhibitor DM96LBV RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DM96LBV RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMJDO2F DI DMJDO2F DMJDO2F DN Adenosine-5'-O-(2-thiodiphosphate) DMJDO2F MI TTQD1SA DMJDO2F MN P2Y purinoceptor (P2RY) DMJDO2F MT DTT DMJDO2F MA Agonist DMJDO2F RN Stimulation of insulin secretion and improvement of glucose tolerance in rat and dog by the P2y-purinoceptor agonist, adenosine-5'-O-(2-thiodiphosphate). Br J Pharmacol. 1993 May;109(1):183-7. DMJDO2F RU https://pubmed.ncbi.nlm.nih.gov/8495239 DMKY7T8 DI DMKY7T8 DMKY7T8 DN Adenosine-5'-Rp-Alpha-Thio-Triphosphate DMKY7T8 MI TT2QM9D DMKY7T8 MN Adenylate cyclase (ADCY) DMKY7T8 MT DTT DMKY7T8 MA Inhibitor DMKY7T8 RN DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Nucleic Acids Res. 2011 Jan;39(Database issue):D1035-41. DMKY7T8 RU https://pubmed.ncbi.nlm.nih.gov/21059682 DM0YQ2I DI DM0YQ2I DM0YQ2I DN Adenylylsulfate DM0YQ2I MI DEQ63LA DM0YQ2I MN Dinucleosidetriphosphatase (FHIT) DM0YQ2I MT DME DM0YQ2I MA Metabolism DM0YQ2I RN Adenylylsulfate-ammonia adenylyltransferase activity is another inherent property of Fhit proteins. Biosci Rep. 2015 Jun 25;35(4). pii: e00235. DM0YQ2I RU https://www.ncbi.nlm.nih.gov/pubmed/?term=26181368 DM0YQ2I DI DM0YQ2I DM0YQ2I DN Adenylylsulfate DM0YQ2I MI DEDG68B DM0YQ2I MN Sulfurylase kinase 1 (PAPSS1) DM0YQ2I MT DME DM0YQ2I MA Metabolism DM0YQ2I RN Human 3'-phosphoadenosine 5'-phosphosulfate synthetase (isoform 1, brain): kinetic properties of the adenosine triphosphate sulfurylase and adenosine 5'-phosphosulfate kinase domains. Biochemistry. 2004 Apr 13;43(14):4356-65. DM0YQ2I RU https://www.ncbi.nlm.nih.gov/pubmed/?term=15065880 DM2XI09 DI DM2XI09 DM2XI09 DN Adipate DM2XI09 MI TTTQR47 DM2XI09 MN Solute carrier family 22 member 8 (SLC22A8) DM2XI09 MT DTT DM2XI09 MA Inhibitor DM2XI09 RN Structural variation governs substrate specificity for organic anion transporter (OAT) homologs. Potential remote sensing by OAT family members. J Biol Chem. 2007 Aug 17;282(33):23841-53. DM2XI09 RU https://pubmed.ncbi.nlm.nih.gov/17553798 DMW5HO0 DI DMW5HO0 DMW5HO0 DN AdoC(Ahx)Arg6 DMW5HO0 MI TTW4Y2M DMW5HO0 MN cAMP protein kinase type II-beta (PRKAR2B) DMW5HO0 MT DTT DMW5HO0 MA Inhibitor DMW5HO0 RN Adenosine-5'-carboxylic acid peptidyl derivatives as inhibitors of protein kinases. Bioorg Med Chem Lett. 1999 May 17;9(10):1447-52. DMW5HO0 RU https://pubmed.ncbi.nlm.nih.gov/10360754 DMW5HO0 DI DMW5HO0 DMW5HO0 DN AdoC(Ahx)Arg6 DMW5HO0 MI TTNAHEX DMW5HO0 MN cAMP-dependent protein kinase A type I (PRKAR1A) DMW5HO0 MT DTT DMW5HO0 MA Inhibitor DMW5HO0 RN Adenosine-5'-carboxylic acid peptidyl derivatives as inhibitors of protein kinases. Bioorg Med Chem Lett. 1999 May 17;9(10):1447-52. DMW5HO0 RU https://pubmed.ncbi.nlm.nih.gov/10360754 DMRSCO2 DI DMRSCO2 DMRSCO2 DN AdoC(Aoc)Arg6 DMRSCO2 MI TTW4Y2M DMRSCO2 MN cAMP protein kinase type II-beta (PRKAR2B) DMRSCO2 MT DTT DMRSCO2 MA Inhibitor DMRSCO2 RN Adenosine-5'-carboxylic acid peptidyl derivatives as inhibitors of protein kinases. Bioorg Med Chem Lett. 1999 May 17;9(10):1447-52. DMRSCO2 RU https://pubmed.ncbi.nlm.nih.gov/10360754 DMRSCO2 DI DMRSCO2 DMRSCO2 DN AdoC(Aoc)Arg6 DMRSCO2 MI TTNAHEX DMRSCO2 MN cAMP-dependent protein kinase A type I (PRKAR1A) DMRSCO2 MT DTT DMRSCO2 MA Inhibitor DMRSCO2 RN Adenosine-5'-carboxylic acid peptidyl derivatives as inhibitors of protein kinases. Bioorg Med Chem Lett. 1999 May 17;9(10):1447-52. DMRSCO2 RU https://pubmed.ncbi.nlm.nih.gov/10360754 DMDLHAB DI DMDLHAB DMDLHAB DN AdoC(Aun)Arg6 DMDLHAB MI TTW4Y2M DMDLHAB MN cAMP protein kinase type II-beta (PRKAR2B) DMDLHAB MT DTT DMDLHAB MA Inhibitor DMDLHAB RN Adenosine-5'-carboxylic acid peptidyl derivatives as inhibitors of protein kinases. Bioorg Med Chem Lett. 1999 May 17;9(10):1447-52. DMDLHAB RU https://pubmed.ncbi.nlm.nih.gov/10360754 DMDLHAB DI DMDLHAB DMDLHAB DN AdoC(Aun)Arg6 DMDLHAB MI TTNAHEX DMDLHAB MN cAMP-dependent protein kinase A type I (PRKAR1A) DMDLHAB MT DTT DMDLHAB MA Inhibitor DMDLHAB RN Adenosine-5'-carboxylic acid peptidyl derivatives as inhibitors of protein kinases. Bioorg Med Chem Lett. 1999 May 17;9(10):1447-52. DMDLHAB RU https://pubmed.ncbi.nlm.nih.gov/10360754 DMPUAFC DI DMPUAFC DMPUAFC DN AdoC(beta-Ala)2AlaArg6 DMPUAFC MI TTW4Y2M DMPUAFC MN cAMP protein kinase type II-beta (PRKAR2B) DMPUAFC MT DTT DMPUAFC MA Inhibitor DMPUAFC RN Adenosine-5'-carboxylic acid peptidyl derivatives as inhibitors of protein kinases. Bioorg Med Chem Lett. 1999 May 17;9(10):1447-52. DMPUAFC RU https://pubmed.ncbi.nlm.nih.gov/10360754 DMPUAFC DI DMPUAFC DMPUAFC DN AdoC(beta-Ala)2AlaArg6 DMPUAFC MI TTNAHEX DMPUAFC MN cAMP-dependent protein kinase A type I (PRKAR1A) DMPUAFC MT DTT DMPUAFC MA Inhibitor DMPUAFC RN Adenosine-5'-carboxylic acid peptidyl derivatives as inhibitors of protein kinases. Bioorg Med Chem Lett. 1999 May 17;9(10):1447-52. DMPUAFC RU https://pubmed.ncbi.nlm.nih.gov/10360754 DMO8D4V DI DMO8D4V DMO8D4V DN AdoC(beta-Ala)Arg6 DMO8D4V MI TTW4Y2M DMO8D4V MN cAMP protein kinase type II-beta (PRKAR2B) DMO8D4V MT DTT DMO8D4V MA Inhibitor DMO8D4V RN Adenosine-5'-carboxylic acid peptidyl derivatives as inhibitors of protein kinases. Bioorg Med Chem Lett. 1999 May 17;9(10):1447-52. DMO8D4V RU https://pubmed.ncbi.nlm.nih.gov/10360754 DMO8D4V DI DMO8D4V DMO8D4V DN AdoC(beta-Ala)Arg6 DMO8D4V MI TTNAHEX DMO8D4V MN cAMP-dependent protein kinase A type I (PRKAR1A) DMO8D4V MT DTT DMO8D4V MA Inhibitor DMO8D4V RN Adenosine-5'-carboxylic acid peptidyl derivatives as inhibitors of protein kinases. Bioorg Med Chem Lett. 1999 May 17;9(10):1447-52. DMO8D4V RU https://pubmed.ncbi.nlm.nih.gov/10360754 DM65B7Y DI DM65B7Y DM65B7Y DN AdoC(betaAsp)2AlaArg6 DM65B7Y MI TTW4Y2M DM65B7Y MN cAMP protein kinase type II-beta (PRKAR2B) DM65B7Y MT DTT DM65B7Y MA Inhibitor DM65B7Y RN Adenosine-5'-carboxylic acid peptidyl derivatives as inhibitors of protein kinases. Bioorg Med Chem Lett. 1999 May 17;9(10):1447-52. DM65B7Y RU https://pubmed.ncbi.nlm.nih.gov/10360754 DM65B7Y DI DM65B7Y DM65B7Y DN AdoC(betaAsp)2AlaArg6 DM65B7Y MI TTNAHEX DM65B7Y MN cAMP-dependent protein kinase A type I (PRKAR1A) DM65B7Y MT DTT DM65B7Y MA Inhibitor DM65B7Y RN Adenosine-5'-carboxylic acid peptidyl derivatives as inhibitors of protein kinases. Bioorg Med Chem Lett. 1999 May 17;9(10):1447-52. DM65B7Y RU https://pubmed.ncbi.nlm.nih.gov/10360754 DM2TWSZ DI DM2TWSZ DM2TWSZ DN AdoC(Dpr)2AlaArg6 DM2TWSZ MI TTW4Y2M DM2TWSZ MN cAMP protein kinase type II-beta (PRKAR2B) DM2TWSZ MT DTT DM2TWSZ MA Inhibitor DM2TWSZ RN Adenosine-5'-carboxylic acid peptidyl derivatives as inhibitors of protein kinases. Bioorg Med Chem Lett. 1999 May 17;9(10):1447-52. DM2TWSZ RU https://pubmed.ncbi.nlm.nih.gov/10360754 DM2TWSZ DI DM2TWSZ DM2TWSZ DN AdoC(Dpr)2AlaArg6 DM2TWSZ MI TTNAHEX DM2TWSZ MN cAMP-dependent protein kinase A type I (PRKAR1A) DM2TWSZ MT DTT DM2TWSZ MA Inhibitor DM2TWSZ RN Adenosine-5'-carboxylic acid peptidyl derivatives as inhibitors of protein kinases. Bioorg Med Chem Lett. 1999 May 17;9(10):1447-52. DM2TWSZ RU https://pubmed.ncbi.nlm.nih.gov/10360754 DM2TWSZ DI DM2TWSZ DM2TWSZ DN AdoC(Dpr)2AlaArg6 DM2TWSZ MI TTER6YH DM2TWSZ MN Casein kinase II alpha (CSNK2A1) DM2TWSZ MT DTT DM2TWSZ MA Inhibitor DM2TWSZ RN Adenosine-5'-carboxylic acid peptidyl derivatives as inhibitors of protein kinases. Bioorg Med Chem Lett. 1999 May 17;9(10):1447-52. DM2TWSZ RU https://pubmed.ncbi.nlm.nih.gov/10360754 DMMWNPT DI DMMWNPT DMMWNPT DN AdoC(GABA)Arg6 DMMWNPT MI TTW4Y2M DMMWNPT MN cAMP protein kinase type II-beta (PRKAR2B) DMMWNPT MT DTT DMMWNPT MA Inhibitor DMMWNPT RN Adenosine-5'-carboxylic acid peptidyl derivatives as inhibitors of protein kinases. Bioorg Med Chem Lett. 1999 May 17;9(10):1447-52. DMMWNPT RU https://pubmed.ncbi.nlm.nih.gov/10360754 DMMWNPT DI DMMWNPT DMMWNPT DN AdoC(GABA)Arg6 DMMWNPT MI TTNAHEX DMMWNPT MN cAMP-dependent protein kinase A type I (PRKAR1A) DMMWNPT MT DTT DMMWNPT MA Inhibitor DMMWNPT RN Adenosine-5'-carboxylic acid peptidyl derivatives as inhibitors of protein kinases. Bioorg Med Chem Lett. 1999 May 17;9(10):1447-52. DMMWNPT RU https://pubmed.ncbi.nlm.nih.gov/10360754 DMVQJP0 DI DMVQJP0 DMVQJP0 DN AdoCGlyArg6 DMVQJP0 MI TTW4Y2M DMVQJP0 MN cAMP protein kinase type II-beta (PRKAR2B) DMVQJP0 MT DTT DMVQJP0 MA Inhibitor DMVQJP0 RN Adenosine-5'-carboxylic acid peptidyl derivatives as inhibitors of protein kinases. Bioorg Med Chem Lett. 1999 May 17;9(10):1447-52. DMVQJP0 RU https://pubmed.ncbi.nlm.nih.gov/10360754 DMVQJP0 DI DMVQJP0 DMVQJP0 DN AdoCGlyArg6 DMVQJP0 MI TTNAHEX DMVQJP0 MN cAMP-dependent protein kinase A type I (PRKAR1A) DMVQJP0 MT DTT DMVQJP0 MA Inhibitor DMVQJP0 RN Adenosine-5'-carboxylic acid peptidyl derivatives as inhibitors of protein kinases. Bioorg Med Chem Lett. 1999 May 17;9(10):1447-52. DMVQJP0 RU https://pubmed.ncbi.nlm.nih.gov/10360754 DMPOU86 DI DMPOU86 DMPOU86 DN ADOCIAQUINONE B DMPOU86 MI TTG8HIM DMPOU86 MN Dual specificity protein phosphatase 1 (DUSP1) DMPOU86 MT DTT DMPOU86 MA Inhibitor DMPOU86 RN Bioactivities of simplified adociaquinone B and naphthoquinone derivatives against Cdc25B, MKP-1, and MKP-3 phosphatases. Bioorg Med Chem. 2009 Mar 15;17(6):2276-81. DMPOU86 RU https://pubmed.ncbi.nlm.nih.gov/19028102 DMPOU86 DI DMPOU86 DMPOU86 DN ADOCIAQUINONE B DMPOU86 MI TTR0SWN DMPOU86 MN M-phase inducer phosphatase 2 (MPIP2) DMPOU86 MT DTT DMPOU86 MA Inhibitor DMPOU86 RN Novel naphthoquinone and quinolinedione inhibitors of CDC25 phosphatase activity with antiproliferative properties. Bioorg Med Chem. 2008 Oct 1;16(19):9040-9. DMPOU86 RU https://pubmed.ncbi.nlm.nih.gov/18789703 DM6MRSC DI DM6MRSC DM6MRSC DN Adociasulfate-2 DM6MRSC MI TTBGTCW DM6MRSC MN Kinesin spindle messenger RNA (KIF11 mRNA) DM6MRSC MT DTT DM6MRSC MA Inhibitor DM6MRSC RN Inhibition of kinesin motor proteins by adociasulfate-2. J Med Chem. 2006 Aug 10;49(16):4857-60. DM6MRSC RU https://pubmed.ncbi.nlm.nih.gov/16884297 DM9IBHU DI DM9IBHU DM9IBHU DN Ado-P-Ch2-P-Ps-Ado DM9IBHU MI TTMS54D DM9IBHU MN Fragile histidine triad protein (FHIT) DM9IBHU MT DTT DM9IBHU MA Inhibitor DM9IBHU RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DM9IBHU RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMQ1F7J DI DMQ1F7J DMQ1F7J DN ADP ribose DMQ1F7J MI TTEBMN7 DMQ1F7J MN Long transient receptor potential channel 2 (TRPM2) DMQ1F7J MT DTT DMQ1F7J MA Activator DMQ1F7J RN ADP-ribose gating of the calcium-permeable LTRPC2 channel revealed by Nudix motif homology. Nature. 2001 May 31;411(6837):595-9. DMQ1F7J RU https://pubmed.ncbi.nlm.nih.gov/11385575 DMVWM75 DI DMVWM75 DMVWM75 DN Adp[-Trp-Arg-Nva-Arg-Tyr-NH2]2 DMVWM75 MI TTRK9JT DMVWM75 MN Neuropeptide Y receptor type 1 (NPY1R) DMVWM75 MT DTT DMVWM75 MA Inhibitor DMVWM75 RN Neuropeptide Y (NPY) Y4 receptor selective agonists based on NPY(32-36): development of an anorectic Y4 receptor selective agonist with picomolar a... J Med Chem. 2006 Apr 20;49(8):2661-5. DMVWM75 RU https://pubmed.ncbi.nlm.nih.gov/16610810 DMVWM75 DI DMVWM75 DMVWM75 DN Adp[-Trp-Arg-Nva-Arg-Tyr-NH2]2 DMVWM75 MI TTJ6WK9 DMVWM75 MN Neuropeptide Y receptor type 2 (NPY2R) DMVWM75 MT DTT DMVWM75 MA Inhibitor DMVWM75 RN Neuropeptide Y (NPY) Y4 receptor selective agonists based on NPY(32-36): development of an anorectic Y4 receptor selective agonist with picomolar a... J Med Chem. 2006 Apr 20;49(8):2661-5. DMVWM75 RU https://pubmed.ncbi.nlm.nih.gov/16610810 DMVWM75 DI DMVWM75 DMVWM75 DN Adp[-Trp-Arg-Nva-Arg-Tyr-NH2]2 DMVWM75 MI TTW4N16 DMVWM75 MN Neuropeptide Y receptor type 4 (NPY4R) DMVWM75 MT DTT DMVWM75 MA Inhibitor DMVWM75 RN Neuropeptide Y (NPY) Y4 receptor selective agonists based on NPY(32-36): development of an anorectic Y4 receptor selective agonist with picomolar a... J Med Chem. 2006 Apr 20;49(8):2661-5. DMVWM75 RU https://pubmed.ncbi.nlm.nih.gov/16610810 DMQBCPK DI DMQBCPK DMQBCPK DN ADR58 DMQBCPK MI TTIVXSE DMQBCPK MN Oncostatin-M (OSM) DMQBCPK MT DTT DMQBCPK RN Therapeutic applications of aptamers. Expert Opin Investig Drugs. 2008 Jan;17(1):43-60. DMQBCPK RU https://pubmed.ncbi.nlm.nih.gov/18095918 DMP8NSU DI DMP8NSU DMP8NSU DN ADRENOGLOMERULOTROPIN DMP8NSU MI TT0K1SC DMP8NSU MN 5-HT 2B receptor (HTR2B) DMP8NSU MT DTT DMP8NSU MA Inhibitor DMP8NSU RN Development, validation, and use of quantitative structure-activity relationship models of 5-hydroxytryptamine (2B) receptor ligands to identify no... J Med Chem. 2010 Nov 11;53(21):7573-86. DMP8NSU RU https://pubmed.ncbi.nlm.nih.gov/20958049 DMP7IS0 DI DMP7IS0 DMP7IS0 DN ADS-0101 DMP7IS0 MI TTG043C DMP7IS0 MN Tumor necrosis factor receptor type I (TNF-R1) DMP7IS0 MT DTT DMP7IS0 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1870). DMP7IS0 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1870 DM7U4OT DI DM7U4OT DM7U4OT DN ADS-100380 DM7U4OT MI TT6R7JZ DM7U4OT MN Histone deacetylase 1 (HDAC1) DM7U4OT MT DTT DM7U4OT MA Inhibitor DM7U4OT RN Identification and optimisation of a series of substituted 5-pyridin-2-yl-thiophene-2-hydroxamic acids as potent histone deacetylase (HDAC) inhibit... Bioorg Med Chem Lett. 2007 Jan 15;17(2):363-9. DM7U4OT RU https://pubmed.ncbi.nlm.nih.gov/17107790 DMEU6MH DI DMEU6MH DMEU6MH DN ADS-102550 DMEU6MH MI TT6R7JZ DMEU6MH MN Histone deacetylase 1 (HDAC1) DMEU6MH MT DTT DMEU6MH MA Inhibitor DMEU6MH RN Identification and optimisation of a series of substituted 5-pyridin-2-yl-thiophene-2-hydroxamic acids as potent histone deacetylase (HDAC) inhibit... Bioorg Med Chem Lett. 2007 Jan 15;17(2):363-9. DMEU6MH RU https://pubmed.ncbi.nlm.nih.gov/17107790 DMXD0C3 DI DMXD0C3 DMXD0C3 DN ADS-102891 DMXD0C3 MI TTX4RTB DMXD0C3 MN Melanin-concentrating hormone receptor 1 (MCHR1) DMXD0C3 MT DTT DMXD0C3 MA Inhibitor DMXD0C3 RN Quinazoline and benzimidazole MCH-1R antagonists. Bioorg Med Chem Lett. 2007 Mar 1;17(5):1403-7. DMXD0C3 RU https://pubmed.ncbi.nlm.nih.gov/17178222 DMMYUB9 DI DMMYUB9 DMMYUB9 DN ADS-103168 DMMYUB9 MI TTX4RTB DMMYUB9 MN Melanin-concentrating hormone receptor 1 (MCHR1) DMMYUB9 MT DTT DMMYUB9 MA Inhibitor DMMYUB9 RN Quinazoline and benzimidazole MCH-1R antagonists. Bioorg Med Chem Lett. 2007 Mar 1;17(5):1403-7. DMMYUB9 RU https://pubmed.ncbi.nlm.nih.gov/17178222 DMUMF0B DI DMUMF0B DMUMF0B DN ADS-103214 DMUMF0B MI TTX4RTB DMUMF0B MN Melanin-concentrating hormone receptor 1 (MCHR1) DMUMF0B MT DTT DMUMF0B MA Inhibitor DMUMF0B RN Quinazoline and benzimidazole MCH-1R antagonists. Bioorg Med Chem Lett. 2007 Mar 1;17(5):1403-7. DMUMF0B RU https://pubmed.ncbi.nlm.nih.gov/17178222 DMH9A4S DI DMH9A4S DMH9A4S DN ADS-103253 DMH9A4S MI TT0K1SC DMH9A4S MN 5-HT 2B receptor (HTR2B) DMH9A4S MT DTT DMH9A4S MA Inhibitor DMH9A4S RN Quinazoline and benzimidazole MCH-1R antagonists. Bioorg Med Chem Lett. 2007 Mar 1;17(5):1403-7. DMH9A4S RU https://pubmed.ncbi.nlm.nih.gov/17178222 DMH9A4S DI DMH9A4S DMH9A4S DN ADS-103253 DMH9A4S MI TTX4RTB DMH9A4S MN Melanin-concentrating hormone receptor 1 (MCHR1) DMH9A4S MT DTT DMH9A4S MA Inhibitor DMH9A4S RN Quinazoline and benzimidazole MCH-1R antagonists. Bioorg Med Chem Lett. 2007 Mar 1;17(5):1403-7. DMH9A4S RU https://pubmed.ncbi.nlm.nih.gov/17178222 DMH9A4S DI DMH9A4S DMH9A4S DN ADS-103253 DMH9A4S MI TTQ6VDM DMH9A4S MN Voltage-gated potassium channel Kv11.1 (KCNH2) DMH9A4S MT DTT DMH9A4S MA Inhibitor DMH9A4S RN Quinazoline and benzimidazole MCH-1R antagonists. Bioorg Med Chem Lett. 2007 Mar 1;17(5):1403-7. DMH9A4S RU https://pubmed.ncbi.nlm.nih.gov/17178222 DMLIOV2 DI DMLIOV2 DMLIOV2 DN ADS-103254 DMLIOV2 MI TTX4RTB DMLIOV2 MN Melanin-concentrating hormone receptor 1 (MCHR1) DMLIOV2 MT DTT DMLIOV2 MA Inhibitor DMLIOV2 RN Quinazoline and benzimidazole MCH-1R antagonists. Bioorg Med Chem Lett. 2007 Mar 1;17(5):1403-7. DMLIOV2 RU https://pubmed.ncbi.nlm.nih.gov/17178222 DMBN6IE DI DMBN6IE DMBN6IE DN ADS-103274 DMBN6IE MI TT0K1SC DMBN6IE MN 5-HT 2B receptor (HTR2B) DMBN6IE MT DTT DMBN6IE MA Inhibitor DMBN6IE RN Quinazoline and benzimidazole MCH-1R antagonists. Bioorg Med Chem Lett. 2007 Mar 1;17(5):1403-7. DMBN6IE RU https://pubmed.ncbi.nlm.nih.gov/17178222 DMBN6IE DI DMBN6IE DMBN6IE DN ADS-103274 DMBN6IE MI TTX4RTB DMBN6IE MN Melanin-concentrating hormone receptor 1 (MCHR1) DMBN6IE MT DTT DMBN6IE MA Inhibitor DMBN6IE RN Quinazoline and benzimidazole MCH-1R antagonists. Bioorg Med Chem Lett. 2007 Mar 1;17(5):1403-7. DMBN6IE RU https://pubmed.ncbi.nlm.nih.gov/17178222 DM0C4QD DI DM0C4QD DM0C4QD DN ADS-103293 DM0C4QD MI TTX4RTB DM0C4QD MN Melanin-concentrating hormone receptor 1 (MCHR1) DM0C4QD MT DTT DM0C4QD MA Inhibitor DM0C4QD RN Quinazoline and benzimidazole MCH-1R antagonists. Bioorg Med Chem Lett. 2007 Mar 1;17(5):1403-7. DM0C4QD RU https://pubmed.ncbi.nlm.nih.gov/17178222 DMM2Q9L DI DMM2Q9L DMM2Q9L DN ADS-103294 DMM2Q9L MI TTX4RTB DMM2Q9L MN Melanin-concentrating hormone receptor 1 (MCHR1) DMM2Q9L MT DTT DMM2Q9L MA Inhibitor DMM2Q9L RN Quinazoline and benzimidazole MCH-1R antagonists. Bioorg Med Chem Lett. 2007 Mar 1;17(5):1403-7. DMM2Q9L RU https://pubmed.ncbi.nlm.nih.gov/17178222 DMKCOYE DI DMKCOYE DMKCOYE DN ADS-103316 DMKCOYE MI TTX4RTB DMKCOYE MN Melanin-concentrating hormone receptor 1 (MCHR1) DMKCOYE MT DTT DMKCOYE MA Inhibitor DMKCOYE RN Quinazoline and benzimidazole MCH-1R antagonists. Bioorg Med Chem Lett. 2007 Mar 1;17(5):1403-7. DMKCOYE RU https://pubmed.ncbi.nlm.nih.gov/17178222 DMA74PO DI DMA74PO DMA74PO DN ADX-63365 DMA74PO MI TTHS256 DMA74PO MN Metabotropic glutamate receptor 5 (mGluR5) DMA74PO MT DTT DMA74PO MA Modulator DMA74PO RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 293). DMA74PO RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=293 DM3WAG6 DI DM3WAG6 DM3WAG6 DN ADX71743 DM3WAG6 MI TT0I76D DM3WAG6 MN Metabotropic glutamate receptor 7 (mGluR7) DM3WAG6 MT DTT DM3WAG6 MA Modulator (allosteric modulator) DM3WAG6 RN ADX71743, a potent and selective negative allosteric modulator of metabotropic glutamate receptor 7: in vitro and in vivo characterization. J Pharmacol Exp Ther. 2013 Mar;344(3):624-36. DM3WAG6 RU https://pubmed.ncbi.nlm.nih.gov/23257312 DM70H6P DI DM70H6P DM70H6P DN ADX-88178 DM70H6P MI TTICZ1O DM70H6P MN Metabotropic glutamate receptor 4 (mGluR4) DM70H6P MT DTT DM70H6P MA Modulator DM70H6P RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 292). DM70H6P RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=292 DMANEH2 DI DMANEH2 DMANEH2 DN AE-9C90CB DMANEH2 MI TTQ13Z5 DMANEH2 MN Muscarinic acetylcholine receptor M3 (CHRM3) DMANEH2 MT DTT DMANEH2 MA Antagonist DMANEH2 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 15). DMANEH2 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=15 DMZ8SV3 DI DMZ8SV3 DMZ8SV3 DN AEKKDEGPYRMEHFRWGSPPKD DMZ8SV3 MI TTEOSZT DMZ8SV3 MN Melanocortin receptor (MCR) DMZ8SV3 MT DTT DMZ8SV3 MA Inhibitor DMZ8SV3 RN Discovery of a beta-MSH-derived MC-4R selective agonist. J Med Chem. 2005 May 5;48(9):3095-8. DMZ8SV3 RU https://pubmed.ncbi.nlm.nih.gov/15857110 DMZ8SV3 DI DMZ8SV3 DMZ8SV3 DN AEKKDEGPYRMEHFRWGSPPKD DMZ8SV3 MI TT0MV2T DMZ8SV3 MN Melanocortin receptor 1 (MC1R) DMZ8SV3 MT DTT DMZ8SV3 MA Inhibitor DMZ8SV3 RN Discovery of a beta-MSH-derived MC-4R selective agonist. J Med Chem. 2005 May 5;48(9):3095-8. DMZ8SV3 RU https://pubmed.ncbi.nlm.nih.gov/15857110 DMZ8SV3 DI DMZ8SV3 DMZ8SV3 DN AEKKDEGPYRMEHFRWGSPPKD DMZ8SV3 MI TTNI91K DMZ8SV3 MN Melanocortin receptor 3 (MC3R) DMZ8SV3 MT DTT DMZ8SV3 MA Inhibitor DMZ8SV3 RN Discovery of a beta-MSH-derived MC-4R selective agonist. J Med Chem. 2005 May 5;48(9):3095-8. DMZ8SV3 RU https://pubmed.ncbi.nlm.nih.gov/15857110 DMZ8SV3 DI DMZ8SV3 DMZ8SV3 DN AEKKDEGPYRMEHFRWGSPPKD DMZ8SV3 MI TTD0CIQ DMZ8SV3 MN Melanocortin receptor 4 (MC4R) DMZ8SV3 MT DTT DMZ8SV3 MA Inhibitor DMZ8SV3 RN Discovery of a beta-MSH-derived MC-4R selective agonist. J Med Chem. 2005 May 5;48(9):3095-8. DMZ8SV3 RU https://pubmed.ncbi.nlm.nih.gov/15857110 DME0I6U DI DME0I6U DME0I6U DN Aerophobin-1 DME0I6U MI TT9JNIC DME0I6U MN Histamine H3 receptor (H3R) DME0I6U MT DTT DME0I6U MA Inhibitor DME0I6U RN Verongamine, a novel bromotyrosine-derived histamine H3-antagonist from the marine sponge Verongula gigantea. J Nat Prod. 1994 Jan;57(1):175-7. DME0I6U RU https://pubmed.ncbi.nlm.nih.gov/8158162 DMULWOG DI DMULWOG DMULWOG DN AEZS-115 DMULWOG MI TT8R70G DMULWOG MN Gonadotropin-releasing hormone receptor (GNRHR) DMULWOG MT DTT DMULWOG MA Antagonist DMULWOG RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 256). DMULWOG RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=256 DMM52FD DI DMM52FD DMM52FD DN AEZS-126 DMM52FD MI TTHBTOP DMM52FD MN PI3-kinase gamma (PIK3CG) DMM52FD MT DTT DMM52FD MA Inhibitor DMM52FD RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2155). DMM52FD RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2155 DMN9RE5 DI DMN9RE5 DMN9RE5 DN AEZS-131 DMN9RE5 MI TT4TQBX DMN9RE5 MN Extracellular signal-regulated kinase 2 (ERK2) DMN9RE5 MT DTT DMN9RE5 MA Inhibitor DMN9RE5 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1495). DMN9RE5 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1495 DMOYADT DI DMOYADT DMOYADT DN AF150(S) DMOYADT MI TTZ9SOR DMOYADT MN Muscarinic acetylcholine receptor M1 (CHRM1) DMOYADT MT DTT DMOYADT MA Agonist DMOYADT RN M1 muscarinic agonists target major hallmarks of Alzheimer's disease--an update. Curr Alzheimer Res. 2007 Dec;4(5):577-80. DMOYADT RU https://pubmed.ncbi.nlm.nih.gov/18220527 DM6B9CK DI DM6B9CK DM6B9CK DN AF-3473 DM6B9CK MI TT07C3Y DM6B9CK MN 5-HT 4 receptor (HTR4) DM6B9CK MT DTT DM6B9CK MA Antagonist DM6B9CK RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 9). DM6B9CK RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=9 DMXQ3MO DI DMXQ3MO DMXQ3MO DN AF353 DMXQ3MO MI TT2THBD DMXQ3MO MN P2X purinoceptor 3 (P2RX3) DMXQ3MO MT DTT DMXQ3MO MA Antagonist DMXQ3MO RN AF-353, a novel, potent and orally bioavailable P2X3/P2X2/3 receptor antagonist. Br J Pharmacol. 2010 Jul;160(6):1387-98. DMXQ3MO RU https://pubmed.ncbi.nlm.nih.gov/20590629 DM65TUP DI DM65TUP DM65TUP DN AFC-5128 DM65TUP MI TT473XN DM65TUP MN P2X purinoceptor 7 (P2RX7) DM65TUP MT DTT DM65TUP MA Antagonist DM65TUP RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 484). DM65TUP RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=484 DME9Y8Q DI DME9Y8Q DME9Y8Q DN AFD(R) DME9Y8Q MI TT9JZCK DME9Y8Q MN Sphingosine-1-phosphate receptor 1 (S1PR1) DME9Y8Q MT DTT DME9Y8Q MA Agonist DME9Y8Q RN The immune modulator FTY720 targets sphingosine 1-phosphate receptors. J Biol Chem. 2002 Jun 14;277(24):21453-7. DME9Y8Q RU https://pubmed.ncbi.nlm.nih.gov/11967257 DME9Y8Q DI DME9Y8Q DME9Y8Q DN AFD(R) DME9Y8Q MI TTDYP7I DME9Y8Q MN Sphingosine-1-phosphate receptor 3 (S1PR3) DME9Y8Q MT DTT DME9Y8Q MA Agonist DME9Y8Q RN The immune modulator FTY720 targets sphingosine 1-phosphate receptors. J Biol Chem. 2002 Jun 14;277(24):21453-7. DME9Y8Q RU https://pubmed.ncbi.nlm.nih.gov/11967257 DME9Y8Q DI DME9Y8Q DME9Y8Q DN AFD(R) DME9Y8Q MI TTZ8C5Q DME9Y8Q MN Sphingosine-1-phosphate receptor 4 (S1PR4) DME9Y8Q MT DTT DME9Y8Q MA Agonist DME9Y8Q RN Sphingosine 1-phosphate (S1P) receptor subtypes S1P1 and S1P3, respectively, regulate lymphocyte recirculation and heart rate. J Biol Chem. 2004 Apr 2;279(14):13839-48. DME9Y8Q RU https://pubmed.ncbi.nlm.nih.gov/14732717 DME9Y8Q DI DME9Y8Q DME9Y8Q DN AFD(R) DME9Y8Q MI TTDZCKV DME9Y8Q MN Sphingosine-1-phosphate receptor 5 (S1PR5) DME9Y8Q MT DTT DME9Y8Q MA Agonist DME9Y8Q RN Sphingosine 1-phosphate (S1P) receptor subtypes S1P1 and S1P3, respectively, regulate lymphocyte recirculation and heart rate. J Biol Chem. 2004 Apr 2;279(14):13839-48. DME9Y8Q RU https://pubmed.ncbi.nlm.nih.gov/14732717 DMNY8H7 DI DMNY8H7 DMNY8H7 DN AF-DX-384 DMNY8H7 MI TTOXS3C DMNY8H7 MN Muscarinic acetylcholine receptor (CHRM) DMNY8H7 MT DTT DMNY8H7 MA Antagonist DMNY8H7 RN Binding of [3H]AF-DX 384 to cloned and native muscarinic receptors. J Pharmacol Exp Ther. 1991 Nov;259(2):601-7. DMNY8H7 RU https://pubmed.ncbi.nlm.nih.gov/1941609 DMNY8H7 DI DMNY8H7 DMNY8H7 DN AF-DX-384 DMNY8H7 MI TTYEG6Q DMNY8H7 MN Muscarinic acetylcholine receptor M2 (CHRM2) DMNY8H7 MT DTT DMNY8H7 MA Modulator DMNY8H7 RN M2/M4 muscarinic receptor binding in the anterior cingulate cortex in schizophrenia and mood disorders. Brain Res Bull. 2005 May 15;65(5):397-403. DMNY8H7 RU https://www.ncbi.nlm.nih.gov/pubmed/15833594 DMNY8H7 DI DMNY8H7 DMNY8H7 DN AF-DX-384 DMNY8H7 MI TTQ3JTF DMNY8H7 MN Muscarinic acetylcholine receptor M4 (CHRM4) DMNY8H7 MT DTT DMNY8H7 MA Modulator DMNY8H7 RN M2/M4 muscarinic receptor binding in the anterior cingulate cortex in schizophrenia and mood disorders. Brain Res Bull. 2005 May 15;65(5):397-403. DMNY8H7 RU https://www.ncbi.nlm.nih.gov/pubmed/15833594 DM6D3NQ DI DM6D3NQ DM6D3NQ DN Affinitak + Cisplatin DM6D3NQ MI TT2MI95 DM6D3NQ MN PKC-alpha messenger RNA (PRKCA mRNA) DM6D3NQ MT DTT DM6D3NQ RN Design and development of antisense drugs. Expert Opin. Drug Discov. 2008 3(10):1189-1207. DM6D3NQ RU http://www.informahealthcare.com/doi/abs/10.1517/17460441.3.10.1177 DMU98ES DI DMU98ES DMU98ES DN Affinitak + Gemcitabine DMU98ES MI TT2MI95 DMU98ES MN PKC-alpha messenger RNA (PRKCA mRNA) DMU98ES MT DTT DMU98ES RN Design and development of antisense drugs. Expert Opin. Drug Discov. 2008 3(10):1189-1207. DMU98ES RU http://www.informahealthcare.com/doi/abs/10.1517/17460441.3.10.1177 DM2R5F9 DI DM2R5F9 DM2R5F9 DN AFLATREME DM2R5F9 MI TTNJYV2 DM2R5F9 MN Gamma-aminobutyric acid receptor (GAR) DM2R5F9 MT DTT DM2R5F9 MA Inhibitor DM2R5F9 RN Partial structures of the fungal toxin aflatrem, methyl-substituted 6,8-dioxabicyclo[3.2.1]octan-2-ones have anticonvulsant activity, Bioorg. Med. Chem. Lett. 5(3):265-270 (1995). DM2R5F9 RU http://www.sciencedirect.com/science/article/pii/0960894X9500021K DM8U1IW DI DM8U1IW DM8U1IW DN AFM-21 DM8U1IW MI TTGKNB4 DM8U1IW MN Epidermal growth factor receptor (EGFR) DM8U1IW MT DTT DM8U1IW RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1797). DM8U1IW RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1797 DM4WVMU DI DM4WVMU DM4WVMU DN AFP-07 DM4WVMU MI TTOFYT1 DM4WVMU MN Prostacyclin receptor (PTGIR) DM4WVMU MT DTT DM4WVMU MA Agonist DM4WVMU RN 7,7-Difluoroprostacyclin derivative, AFP-07, a highly selective and potent agonist for the prostacyclin receptor. Prostaglandins. 1997 Feb;53(2):83-90. DM4WVMU RU https://pubmed.ncbi.nlm.nih.gov/9112287 DMF0SPB DI DMF0SPB DMF0SPB DN AG 1024 DMF0SPB MI TTQFBMY DMF0SPB MN IGF1R messenger RNA (IGF1R mRNA) DMF0SPB MT DTT DMF0SPB MA Inhibitor DMF0SPB RN Specific inhibition of insulin-like growth factor-1 and insulin receptor tyrosine kinase activity and biological function by tyrphostins. Endocrinology. 1997 Apr;138(4):1427-33. DMF0SPB RU https://pubmed.ncbi.nlm.nih.gov/9075698 DMDYS0L DI DMDYS0L DMDYS0L DN AG 112 DMDYS0L MI TTGKNB4 DMDYS0L MN Epidermal growth factor receptor (EGFR) DMDYS0L MT DTT DMDYS0L MA Inhibitor DMDYS0L RN Tyrphostins I: synthesis and biological activity of protein tyrosine kinase inhibitors. J Med Chem. 1989 Oct;32(10):2344-52. DMDYS0L RU https://pubmed.ncbi.nlm.nih.gov/2552117 DMSOUI0 DI DMSOUI0 DMSOUI0 DN AG 9 DMSOUI0 MI TTGKNB4 DMSOUI0 MN Epidermal growth factor receptor (EGFR) DMSOUI0 MT DTT DMSOUI0 MA Inhibitor DMSOUI0 RN Tyrphostins I: synthesis and biological activity of protein tyrosine kinase inhibitors. J Med Chem. 1989 Oct;32(10):2344-52. DMSOUI0 RU https://pubmed.ncbi.nlm.nih.gov/2552117 DMHFYNE DI DMHFYNE DMHFYNE DN AG-014376 DMHFYNE MI TTVDSZ0 DMHFYNE MN Poly [ADP-ribose] polymerase 1 (PARP1) DMHFYNE MT DTT DMHFYNE MA Inhibitor DMHFYNE RN Design, synthesis, and evaluation of 3,4-dihydro-2H-[1,4]diazepino[6,7,1-hi]indol-1-ones as inhibitors of poly(ADP-ribose) polymerase. J Med Chem. 2004 Oct 21;47(22):5467-81. DMHFYNE RU https://pubmed.ncbi.nlm.nih.gov/15481984 DMW7H28 DI DMW7H28 DMW7H28 DN AG-09/1 DMW7H28 MI TT5Y4EM DMW7H28 MN N-formyl peptide receptor (FPR1) DMW7H28 MT DTT DMW7H28 MA Agonist DMW7H28 RN Identification of novel small-molecule agonists for human formyl peptide receptors and pharmacophore models of their recognition. Mol Pharmacol. 2010 Feb;77(2):159-70. DMW7H28 RU https://pubmed.ncbi.nlm.nih.gov/19903830 DMZINUY DI DMZINUY DMZINUY DN AG-11/03 DMZINUY MI TT5Y4EM DMZINUY MN N-formyl peptide receptor (FPR1) DMZINUY MT DTT DMZINUY MA Agonist DMZINUY RN Molecular docking of 2-(benzimidazol-2-ylthio)-N-phenylacetamide-derived small-molecule agonists of human formyl peptide receptor 1. J Mol Model. 2012 Jun;18(6):2831-43. DMZINUY RU https://pubmed.ncbi.nlm.nih.gov/22127612 DMVR9G0 DI DMVR9G0 DMVR9G0 DN AG-14 DMVR9G0 MI TT5Y4EM DMVR9G0 MN N-formyl peptide receptor (FPR1) DMVR9G0 MT DTT DMVR9G0 MA Agonist DMVR9G0 RN High-throughput screening for small-molecule activators of neutrophils: identification of novel N-formyl peptide receptor agonists. Mol Pharmacol. 2007 Apr;71(4):1061-74. DMVR9G0 RU https://pubmed.ncbi.nlm.nih.gov/17229869 DMT3ML6 DI DMT3ML6 DMT3ML6 DN AG-213 DMT3ML6 MI TTGKNB4 DMT3ML6 MN Epidermal growth factor receptor (EGFR) DMT3ML6 MT DTT DMT3ML6 MA Inhibitor DMT3ML6 RN Syntheses of 4-(indole-3-yl)quinazolines: a new class of epidermal growth factor receptor tyrosine kinase inhibitors. Eur J Med Chem. 2008 Jul;43(7):1478-88. DMT3ML6 RU https://pubmed.ncbi.nlm.nih.gov/17981366 DMT3ML6 DI DMT3ML6 DMT3ML6 DN AG-213 DMT3ML6 MI TTR5TV4 DMT3ML6 MN ERBB2 messenger RNA (HER2 mRNA) DMT3ML6 MT DTT DMT3ML6 MA Inhibitor DMT3ML6 RN Syntheses of 4-(indole-3-yl)quinazolines: a new class of epidermal growth factor receptor tyrosine kinase inhibitors. Eur J Med Chem. 2008 Jul;43(7):1478-88. DMT3ML6 RU https://pubmed.ncbi.nlm.nih.gov/17981366 DMMFQR2 DI DMMFQR2 DMMFQR2 DN AG-26 DMMFQR2 MI TTOJ1NF DMMFQR2 MN FMLP-related receptor I (FPR2) DMMFQR2 MT DTT DMMFQR2 MA Agonist DMMFQR2 RN Identification of novel small-molecule agonists for human formyl peptide receptors and pharmacophore models of their recognition. Mol Pharmacol. 2010 Feb;77(2):159-70. DMMFQR2 RU https://pubmed.ncbi.nlm.nih.gov/19903830 DM9KIS8 DI DM9KIS8 DM9KIS8 DN AG-538 DM9KIS8 MI TTGKNB4 DM9KIS8 MN Epidermal growth factor receptor (EGFR) DM9KIS8 MT DTT DM9KIS8 MA Inhibitor DM9KIS8 RN Protein-tyrosine kinase inhibition: mechanism-based discovery of antitumor agents. J Nat Prod. 1992 Nov;55(11):1529-60. DM9KIS8 RU https://pubmed.ncbi.nlm.nih.gov/1479375 DMAUJOM DI DMAUJOM DMAUJOM DN agatoxin 489 DMAUJOM MI TTMI6F5 DMAUJOM MN Transient receptor potential cation channel V1 (TRPV1) DMAUJOM MT DTT DMAUJOM MA Blocker (channel blocker) DMAUJOM RN An inhibitor of TRPV1 channels isolated from funnel Web spider venom. Biochemistry. 2005 Nov 29;44(47):15544-9. DMAUJOM RU https://pubmed.ncbi.nlm.nih.gov/16300403 DM83951 DI DM83951 DM83951 DN AG-E-85378 DM83951 MI TTUTJGQ DM83951 MN Vascular endothelial growth factor receptor 2 (KDR) DM83951 MT DTT DM83951 MA Inhibitor DM83951 RN Discovery of N-phenyl nicotinamides as potent inhibitors of Kdr. Bioorg Med Chem Lett. 2007 Nov 1;17(21):6003-8. DM83951 RU https://pubmed.ncbi.nlm.nih.gov/17869515 DMOJ3CW DI DMOJ3CW DMOJ3CW DN AGELADINE A DMOJ3CW MI TTXZ0KQ DMOJ3CW MN Matrix metalloproteinase-12 (MMP-12) DMOJ3CW MT DTT DMOJ3CW MA Inhibitor DMOJ3CW RN Synthesis of novel ageladine A analogs showing more potent matrix metalloproteinase (MMP)-12 inhibitory activity than the natural product. Bioorg Med Chem Lett. 2009 Sep 15;19(18):5461-3. DMOJ3CW RU https://pubmed.ncbi.nlm.nih.gov/19665375 DM26AMU DI DM26AMU DM26AMU DN AGK2 DM26AMU MI TTLKF5M DM26AMU MN NAD-dependent deacetylase sirtuin-2 (SIRT2) DM26AMU MT DTT DM26AMU MA Inhibitor DM26AMU RN Sirtuin 2 inhibitors rescue alpha-synuclein-mediated toxicity in models of Parkinson's disease. Science. 2007 Jul 27;317(5837):516-9. DM26AMU RU https://pubmed.ncbi.nlm.nih.gov/17588900 DMM9A5N DI DMM9A5N DMM9A5N DN AGL 2043 DMM9A5N MI TTI7421 DMM9A5N MN Platelet-derived growth factor receptor beta (PDGFRB) DMM9A5N MT DTT DMM9A5N MA Inhibitor DMM9A5N RN Tricyclic quinoxalines as potent kinase inhibitors of PDGFR kinase, Flt3 and Kit. Bioorg Med Chem. 2003 May 1;11(9):2007-18. DMM9A5N RU https://pubmed.ncbi.nlm.nih.gov/12670652 DMSBZ29 DI DMSBZ29 DMSBZ29 DN Agmatine DMSBZ29 MI TTLGDIS DMSBZ29 MN Acid-sensing ion channel 3 (ASIC3) DMSBZ29 MT DTT DMSBZ29 MA Activator DMSBZ29 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 686). 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DMSBZ29 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=22039822 DMSBZ29 DI DMSBZ29 DMSBZ29 DN Agmatine DMSBZ29 MI DE8LBNO DMSBZ29 MN Poly [ADP-ribose] polymerase 3 (PARP3) DMSBZ29 MT DME DMSBZ29 MA Metabolism DMSBZ29 RN Mono-ADP-ribosylation catalyzed by arginine-specific ADP-ribosyltransferases. Methods Mol Biol. 2018;1813:149-165. DMSBZ29 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=30097866 DMTPV4Y DI DMTPV4Y DMTPV4Y DN AGN 191976 DMTPV4Y MI TT2O84V DMTPV4Y MN Thromboxane A2 receptor (TBXA2R) DMTPV4Y MT DTT DMTPV4Y MA Agonist DMTPV4Y RN Evidence for human thromboxane receptor heterogeneity using a novel series of 9,11-cyclic carbonate derivatives of prostaglandin F2 alpha. Br J Pharmacol. 1996 Mar;117(6):1171-80. DMTPV4Y RU https://pubmed.ncbi.nlm.nih.gov/8882612 DM53R94 DI DM53R94 DM53R94 DN AGN-190383 DM53R94 MI TT9V5JH DM53R94 MN Phospholipase A2 (PLA2G1B) DM53R94 MT DTT DM53R94 MA Modulator DM53R94 RN AGN 190383, a novel phospholipase inhibitor with topical anti-inflammatory activity. Agents Actions. 1991 Sep;34(1-2):70-2. DM53R94 RU https://www.ncbi.nlm.nih.gov/pubmed/1793055 DMIKDAR DI DMIKDAR DMIKDAR DN AGN-190744 DMIKDAR MI TT5HONZ DMIKDAR MN Calcium channel unspecific (CaC) DMIKDAR MT DTT DMIKDAR MA Modulator DMIKDAR RN The antiinflammatory activity of topically applied novel calcium-channel antagonists. Inflammation. 1995 Apr;19(2):261-75. DMIKDAR RU https://www.ncbi.nlm.nih.gov/pubmed/7601508 DMISJXB DI DMISJXB DMISJXB DN AGN192093 DMISJXB MI TT2O84V DMISJXB MN Thromboxane A2 receptor (TBXA2R) DMISJXB MT DTT DMISJXB MA Agonist DMISJXB RN Evidence for human thromboxane receptor heterogeneity using a novel series of 9,11-cyclic carbonate derivatives of prostaglandin F2 alpha. Br J Pharmacol. 1996 Mar;117(6):1171-80. DMISJXB RU https://pubmed.ncbi.nlm.nih.gov/8882612 DM946RA DI DM946RA DM946RA DN AGN-192172 DM946RA MI TTNGILX DM946RA MN Adrenergic receptor alpha-1A (ADRA1A) DM946RA MT DTT DM946RA MA Inhibitor DM946RA RN Analogs of UK 14,304: Structural features responsible for alpha2 adrenoceptor activity, Bioorg. Med. Chem. Lett. 5(15):1745-1750 (1995). DM946RA RU http://www.sciencedirect.com/science/article/pii/0960894X95002955 DM946RA DI DM946RA DM946RA DN AGN-192172 DM946RA MI TTBRKXS DM946RA MN Adrenergic receptor alpha-1B (ADRA1B) DM946RA MT DTT DM946RA MA Inhibitor DM946RA RN Analogs of UK 14,304: Structural features responsible for alpha2 adrenoceptor activity, Bioorg. Med. Chem. Lett. 5(15):1745-1750 (1995). DM946RA RU http://www.sciencedirect.com/science/article/pii/0960894X95002955 DM946RA DI DM946RA DM946RA DN AGN-192172 DM946RA MI TT34BHT DM946RA MN Adrenergic receptor alpha-1D (ADRA1D) DM946RA MT DTT DM946RA MA Inhibitor DM946RA RN Analogs of UK 14,304: Structural features responsible for alpha2 adrenoceptor activity, Bioorg. Med. Chem. Lett. 5(15):1745-1750 (1995). DM946RA RU http://www.sciencedirect.com/science/article/pii/0960894X95002955 DMC0YOE DI DMC0YOE DMC0YOE DN AGN193109 DMC0YOE MI TTW38KT DMC0YOE MN Retinoic acid receptor alpha (RARA) DMC0YOE MT DTT DMC0YOE MA Antagonist DMC0YOE RN Therapeutic applications for ligands of retinoid receptors. Curr Pharm Des. 2000 Jan;6(1):25-58. DMC0YOE RU https://pubmed.ncbi.nlm.nih.gov/10637371 DMC0YOE DI DMC0YOE DMC0YOE DN AGN193109 DMC0YOE MI TTISP28 DMC0YOE MN Retinoic acid receptor beta (RARB) DMC0YOE MT DTT DMC0YOE MA Antagonist DMC0YOE RN Therapeutic applications for ligands of retinoid receptors. Curr Pharm Des. 2000 Jan;6(1):25-58. DMC0YOE RU https://pubmed.ncbi.nlm.nih.gov/10637371 DMC0YOE DI DMC0YOE DMC0YOE DN AGN193109 DMC0YOE MI TT1Q3IE DMC0YOE MN Retinoic acid receptor gamma (RARG) DMC0YOE MT DTT DMC0YOE MA Antagonist DMC0YOE RN Therapeutic applications for ligands of retinoid receptors. Curr Pharm Des. 2000 Jan;6(1):25-58. DMC0YOE RU https://pubmed.ncbi.nlm.nih.gov/10637371 DMEB93D DI DMEB93D DMEB93D DN AGN193836 DMEB93D MI TTW38KT DMEB93D MN Retinoic acid receptor alpha (RARA) DMEB93D MT DTT DMEB93D MA Agonist DMEB93D RN Synthesis and biological activity of retinoic acid receptor-alpha specific amides. Bioorg Med Chem Lett. 2002 Nov 4;12(21):3145-8. DMEB93D RU https://pubmed.ncbi.nlm.nih.gov/12372520 DM5ECDM DI DM5ECDM DM5ECDM DN AGN-34 DM5ECDM MI TTS4UGC DM5ECDM MN Farnesoid X-activated receptor (FXR) DM5ECDM MT DTT DM5ECDM MA Inhibitor DM5ECDM RN Farnesoid X receptor: from structure to potential clinical applications. J Med Chem. 2005 Aug 25;48(17):5383-403. DM5ECDM RU https://pubmed.ncbi.nlm.nih.gov/16107136 DM5ECDM DI DM5ECDM DM5ECDM DN AGN-34 DM5ECDM MI TT6PEUO DM5ECDM MN Retinoic acid receptor RXR-alpha (RXRA) DM5ECDM MT DTT DM5ECDM MA Inhibitor DM5ECDM RN Farnesoid X receptor: from structure to potential clinical applications. J Med Chem. 2005 Aug 25;48(17):5383-403. DM5ECDM RU https://pubmed.ncbi.nlm.nih.gov/16107136 DM5ECDM DI DM5ECDM DM5ECDM DN AGN-34 DM5ECDM MI TTKLV96 DM5ECDM MN Retinoic acid receptor RXR-beta (RXRB) DM5ECDM MT DTT DM5ECDM MA Inhibitor DM5ECDM RN Farnesoid X receptor: from structure to potential clinical applications. J Med Chem. 2005 Aug 25;48(17):5383-403. DM5ECDM RU https://pubmed.ncbi.nlm.nih.gov/16107136 DM5ECDM DI DM5ECDM DM5ECDM DN AGN-34 DM5ECDM MI TTH029C DM5ECDM MN Retinoic acid receptor RXR-gamma (RXRG) DM5ECDM MT DTT DM5ECDM MA Inhibitor DM5ECDM RN Farnesoid X receptor: from structure to potential clinical applications. J Med Chem. 2005 Aug 25;48(17):5383-403. DM5ECDM RU https://pubmed.ncbi.nlm.nih.gov/16107136 DMT9FJZ DI DMT9FJZ DMT9FJZ DN AGROCLAVINE DMT9FJZ MI TTSQIFT DMT9FJZ MN 5-HT 1A receptor (HTR1A) DMT9FJZ MT DTT DMT9FJZ MA Inhibitor DMT9FJZ RN Ergolines as selective 5-HT1 agonists. J Med Chem. 1988 Aug;31(8):1512-9. DMT9FJZ RU https://pubmed.ncbi.nlm.nih.gov/2456389 DMT9FJZ DI DMT9FJZ DMT9FJZ DN AGROCLAVINE DMT9FJZ MI TT6MSOK DMT9FJZ MN 5-HT 1D receptor (HTR1D) DMT9FJZ MT DTT DMT9FJZ MA Inhibitor DMT9FJZ RN Ergolines as selective 5-HT1 agonists. J Med Chem. 1988 Aug;31(8):1512-9. DMT9FJZ RU https://pubmed.ncbi.nlm.nih.gov/2456389 DMP9QW0 DI DMP9QW0 DMP9QW0 DN AGT-2000 DMP9QW0 MI TTGKNB4 DMP9QW0 MN Epidermal growth factor receptor (EGFR) DMP9QW0 MT DTT DMP9QW0 MA Modulator DMP9QW0 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1797). DMP9QW0 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1797 DMMO9YR DI DMMO9YR DMMO9YR DN AGTAD[CFWKYC]V DMMO9YR MI TTW5UDX DMMO9YR MN Urotensin II receptor (UTS2R) DMMO9YR MT DTT DMMO9YR MA Inhibitor DMMO9YR RN Urotensin-II receptor modulators as potential drugs. J Med Chem. 2010 Apr 8;53(7):2695-708. DMMO9YR RU https://pubmed.ncbi.nlm.nih.gov/20043680 DMF7ZYQ DI DMF7ZYQ DMF7ZYQ DN AH 11110 DMF7ZYQ MI TTBRKXS DMF7ZYQ MN Adrenergic receptor alpha-1B (ADRA1B) DMF7ZYQ MT DTT DMF7ZYQ MA Antagonist DMF7ZYQ RN Structure activity relationships of a series of buspirone analogs at alpha-1 adrenoceptors: further evidence that rat aorta alpha-1 adrenoceptors are of the alpha-1D-subtype. J Pharmacol Exp Ther. 1996 Jul;278(1):136-44. DMF7ZYQ RU https://pubmed.ncbi.nlm.nih.gov/8764344 DM2VEHG DI DM2VEHG DM2VEHG DN AH13205 DM2VEHG MI TT1ZAVI DM2VEHG MN Prostaglandin E2 receptor EP2 (PTGER2) DM2VEHG MT DTT DM2VEHG MA Agonist DM2VEHG RN Ligand binding specificities of the eight types and subtypes of the mouse prostanoid receptors expressed in Chinese hamster ovary cells. Br J Pharmacol. 1997 Sep;122(2):217-24. DM2VEHG RU https://pubmed.ncbi.nlm.nih.gov/9313928 DM4S1Y6 DI DM4S1Y6 DM4S1Y6 DN AH23848 DM4S1Y6 MI TT79WV3 DM4S1Y6 MN Prostaglandin E2 receptor EP4 (PTGER4) DM4S1Y6 MT DTT DM4S1Y6 MA Antagonist DM4S1Y6 RN Molecular cloning and characterization of the four rat prostaglandin E2 prostanoid receptor subtypes. Eur J Pharmacol. 1997 Dec 11;340(2-3):227-41. DM4S1Y6 RU https://pubmed.ncbi.nlm.nih.gov/9537820 DM4S1Y6 DI DM4S1Y6 DM4S1Y6 DN AH23848 DM4S1Y6 MI TT2O84V DM4S1Y6 MN Thromboxane A2 receptor (TBXA2R) DM4S1Y6 MT DTT DM4S1Y6 MA Antagonist DM4S1Y6 RN The utilization of recombinant prostanoid receptors to determine the affinities and selectivities of prostaglandins and related analogs. Biochim Biophys Acta. 2000 Jan 17;1483(2):285-93. DM4S1Y6 RU https://pubmed.ncbi.nlm.nih.gov/10634944 DMKN3R9 DI DMKN3R9 DMKN3R9 DN AH6809 DMKN3R9 MI TTNVEIR DMKN3R9 MN Prostaglandin D2 receptor (PTGDR) DMKN3R9 MT DTT DMKN3R9 MA Antagonist DMKN3R9 RN The utilization of recombinant prostanoid receptors to determine the affinities and selectivities of prostaglandins and related analogs. Biochim Biophys Acta. 2000 Jan 17;1483(2):285-93. DMKN3R9 RU https://pubmed.ncbi.nlm.nih.gov/10634944 DMKN3R9 DI DMKN3R9 DMKN3R9 DN AH6809 DMKN3R9 MI TTG1QMU DMKN3R9 MN Prostaglandin E2 receptor EP1 (PTGER1) DMKN3R9 MT DTT DMKN3R9 MA Antagonist DMKN3R9 RN Molecular cloning and characterization of the four rat prostaglandin E2 prostanoid receptor subtypes. Eur J Pharmacol. 1997 Dec 11;340(2-3):227-41. DMKN3R9 RU https://pubmed.ncbi.nlm.nih.gov/9537820 DMKN3R9 DI DMKN3R9 DMKN3R9 DN AH6809 DMKN3R9 MI TT1ZAVI DMKN3R9 MN Prostaglandin E2 receptor EP2 (PTGER2) DMKN3R9 MT DTT DMKN3R9 MA Antagonist DMKN3R9 RN The utilization of recombinant prostanoid receptors to determine the affinities and selectivities of prostaglandins and related analogs. Biochim Biophys Acta. 2000 Jan 17;1483(2):285-93. DMKN3R9 RU https://pubmed.ncbi.nlm.nih.gov/10634944 DMKN3R9 DI DMKN3R9 DMKN3R9 DN AH6809 DMKN3R9 MI TTPNGDE DMKN3R9 MN Prostaglandin E2 receptor EP3 (PTGER3) DMKN3R9 MT DTT DMKN3R9 MA Antagonist DMKN3R9 RN The utilization of recombinant prostanoid receptors to determine the affinities and selectivities of prostaglandins and related analogs. Biochim Biophys Acta. 2000 Jan 17;1483(2):285-93. DMKN3R9 RU https://pubmed.ncbi.nlm.nih.gov/10634944 DMVZLIB DI DMVZLIB DMVZLIB DN AHL DMVZLIB MI TT12KOD DMVZLIB MN P53 messenger RNA (TP53 mRNA) DMVZLIB MT DTT DMVZLIB RN Phase 2 randomized study of p53 antisense oligonucleotide (cenersen) plus idarubicin with or without cytarabine in refractory and relapsed acute myeloid leukemia. Cancer. 2012 Jan 15;118(2):418-27. DMVZLIB RU https://pubmed.ncbi.nlm.nih.gov/21717444 DM8G6O4 DI DM8G6O4 DM8G6O4 DN AHPN DM8G6O4 MI TT1Q3IE DM8G6O4 MN Retinoic acid receptor gamma (RARG) DM8G6O4 MT DTT DM8G6O4 MA Agonist DM8G6O4 RN Synthesis, structure-affinity relationships, and biological activities of ligands binding to retinoic acid receptor subtypes. J Med Chem. 1995 Dec 22;38(26):4993-5006. DM8G6O4 RU https://pubmed.ncbi.nlm.nih.gov/8544175 DM3LCDK DI DM3LCDK DM3LCDK DN AIDA DM3LCDK MI TTVBPDM DM3LCDK MN Metabotropic glutamate receptor 1 (mGluR1) DM3LCDK MT DTT DM3LCDK MA Antagonist DM3LCDK RN [3H]R214127: a novel high-affinity radioligand for the mGlu1 receptor reveals a common binding site shared by multiple allosteric antagonists. Mol Pharmacol. 2003 May;63(5):1082-93. DM3LCDK RU https://pubmed.ncbi.nlm.nih.gov/12695537 DMUQ6XH DI DMUQ6XH DMUQ6XH DN AIKO-151 DMUQ6XH MI TTKWM86 DMUQ6XH MN Opioid receptor mu (MOP) DMUQ6XH MT DTT DMUQ6XH MA Antagonist DMUQ6XH RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 319). DMUQ6XH RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=319 DML5Y1Q DI DML5Y1Q DML5Y1Q DN AIKO-152 DML5Y1Q MI TTKWM86 DML5Y1Q MN Opioid receptor mu (MOP) DML5Y1Q MT DTT DML5Y1Q MA Modulator DML5Y1Q RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 319). DML5Y1Q RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=319 DMHMVOI DI DMHMVOI DMHMVOI DN Ajinomoto 1 DMHMVOI MI TTXHYV6 DMHMVOI MN Voltage-gated L-type calcium channel (L-CaC) DMHMVOI MT DTT DMHMVOI MA Blocker DMHMVOI RN Recent updates of N-type calcium channel blockers with therapeutic potential for neuropathic pain and stroke. Curr Top Med Chem. 2009;9(4):377-95. DMHMVOI RU https://pubmed.ncbi.nlm.nih.gov/19442208 DMZE45V DI DMZE45V DMZE45V DN Ajinomoto 2 DMZE45V MI TTXHYV6 DMZE45V MN Voltage-gated L-type calcium channel (L-CaC) DMZE45V MT DTT DMZE45V MA Blocker DMZE45V RN Recent updates of N-type calcium channel blockers with therapeutic potential for neuropathic pain and stroke. Curr Top Med Chem. 2009;9(4):377-95. DMZE45V RU https://pubmed.ncbi.nlm.nih.gov/19442208 DMG12AE DI DMG12AE DMG12AE DN Ajinomoto 3 DMG12AE MI TTXHYV6 DMG12AE MN Voltage-gated L-type calcium channel (L-CaC) DMG12AE MT DTT DMG12AE MA Blocker DMG12AE RN Recent updates of N-type calcium channel blockers with therapeutic potential for neuropathic pain and stroke. Curr Top Med Chem. 2009;9(4):377-95. DMG12AE RU https://pubmed.ncbi.nlm.nih.gov/19442208 DMWKPJH DI DMWKPJH DMWKPJH DN AK198 DMWKPJH MI TTFBNVI DMWKPJH MN Aldose reductase (AKR1B1) DMWKPJH MT DTT DMWKPJH MA Inhibitor DMWKPJH RN The Effect of Halogen-to-Hydrogen Bond Substitution on Human Aldose Reductase Inhibition. ACS Chem Biol. 2015 Jul 17;10(7):1637-42. DMWKPJH RU https://pubmed.ncbi.nlm.nih.gov/25919404 DMQ90PJ DI DMQ90PJ DMQ90PJ DN AK-41099 DMQ90PJ MI DESN3MD DMQ90PJ MN Trans-L-3-hydroxyproline dehydratase (L3HYPDH) DMQ90PJ MT DME DMQ90PJ MA Metabolism DMQ90PJ RN An enzymatic method to estimate the content of L-hydroxyproline. J Biotechnol. 2015 Apr 10;199:9-16. DMQ90PJ RU https://www.ncbi.nlm.nih.gov/pubmed/?term=25678137 DMANYU5 DI DMANYU5 DMANYU5 DN AKN-028 DMANYU5 MI TTGJCWZ DMANYU5 MN Fms-like tyrosine kinase 3 (FLT-3) DMANYU5 MT DTT DMANYU5 MA Inhibitor DMANYU5 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1807). DMANYU5 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1807 DM4E6H1 DI DM4E6H1 DM4E6H1 DN AKNADILACTAM DM4E6H1 MI TT27RFC DM4E6H1 MN Opioid receptor delta (OPRD1) DM4E6H1 MT DTT DM4E6H1 MA Inhibitor DM4E6H1 RN Hasubanan alkaloids with delta-opioid binding affinity from the aerial parts of Stephania japonica. J Nat Prod. 2010 May 28;73(5):988-91. DM4E6H1 RU https://pubmed.ncbi.nlm.nih.gov/20426456 DMDVIT1 DI DMDVIT1 DMDVIT1 DN Akt inhibitor VIII DMDVIT1 MI TTWTSCV DMDVIT1 MN RAC-alpha serine/threonine-protein kinase (AKT1) DMDVIT1 MT DTT DMDVIT1 MA Inhibitor DMDVIT1 RN Allosteric Akt (PKB) inhibitors: discovery and SAR of isozyme selective inhibitors. Bioorg Med Chem Lett. 2005 Feb 1;15(3):761-4. DMDVIT1 RU https://pubmed.ncbi.nlm.nih.gov/15664853 DMDVIT1 DI DMDVIT1 DMDVIT1 DN Akt inhibitor VIII DMDVIT1 MI TTH24WI DMDVIT1 MN RAC-beta serine/threonine-protein kinase (AKT2) DMDVIT1 MT DTT DMDVIT1 MA Inhibitor DMDVIT1 RN Allosteric Akt (PKB) inhibitors: discovery and SAR of isozyme selective inhibitors. Bioorg Med Chem Lett. 2005 Feb 1;15(3):761-4. DMDVIT1 RU https://pubmed.ncbi.nlm.nih.gov/15664853 DMDVIT1 DI DMDVIT1 DMDVIT1 DN Akt inhibitor VIII DMDVIT1 MI TTAZ05C DMDVIT1 MN RAC-gamma serine/threonine-protein kinase (AKT3) DMDVIT1 MT DTT DMDVIT1 MA Inhibitor DMDVIT1 RN Allosteric Akt (PKB) inhibitors: discovery and SAR of isozyme selective inhibitors. Bioorg Med Chem Lett. 2005 Feb 1;15(3):761-4. DMDVIT1 RU https://pubmed.ncbi.nlm.nih.gov/15664853 DMJW4I5 DI DMJW4I5 DMJW4I5 DN AKUAMMIGINE DMJW4I5 MI TTWG9A4 DMJW4I5 MN Adrenergic receptor alpha-2A (ADRA2A) DMJW4I5 MT DTT DMJW4I5 MA Inhibitor DMJW4I5 RN Alpha- and beta-adrenoceptors: from the gene to the clinic. 2. Structure-activity relationships and therapeutic applications. J Med Chem. 1995 Sep 15;38(19):3681-716. DMJW4I5 RU https://pubmed.ncbi.nlm.nih.gov/7562902 DM8DYWN DI DM8DYWN DM8DYWN DN AKUAMMINE DM8DYWN MI TTKWM86 DM8DYWN MN Opioid receptor mu (MOP) DM8DYWN MT DTT DM8DYWN MA Inhibitor DM8DYWN RN Akuammine and dihydroakuammine, two indolomonoterpene alkaloids displaying affinity for opioid receptors. J Nat Prod. 1992 Mar;55(3):380-4. DM8DYWN RU https://pubmed.ncbi.nlm.nih.gov/1317407 DM0JE4N DI DM0JE4N DM0JE4N DN AL12180 DM0JE4N MI TTT2ZAR DM0JE4N MN Prostaglandin F2-alpha receptor (PTGFR) DM0JE4N MT DTT DM0JE4N MA Agonist DM0JE4N RN Preclinical pharmacology of AL-12182, a new ocular hypotensive 11-oxa prostaglandin analog. J Ocul Pharmacol Ther. 2006 Oct;22(5):291-309. DM0JE4N RU https://pubmed.ncbi.nlm.nih.gov/17076623 DM7XHDC DI DM7XHDC DM7XHDC DN AL-209 DM7XHDC MI TTML2WA DM7XHDC MN Tubulin (TUB) DM7XHDC MT DTT DM7XHDC MA Modulator DM7XHDC RN Protection against tauopathy by the drug candidates NAP (davunetide) and D-SAL: biochemical, cellular and behavioral aspects. Curr Pharm Des. 2011;17(25):2603-12. DM7XHDC RU https://pubmed.ncbi.nlm.nih.gov/21728979 DM69X2Z DI DM69X2Z DM69X2Z DN AL-309 DM69X2Z MI TTML2WA DM69X2Z MN Tubulin (TUB) DM69X2Z MT DTT DM69X2Z MA Modulator DM69X2Z RN Protection against tauopathy by the drug candidates NAP (davunetide) and D-SAL: biochemical, cellular and behavioral aspects. Curr Pharm Des. 2011;17(25):2603-12. DM69X2Z RU https://pubmed.ncbi.nlm.nih.gov/21728979 DMRJ2GK DI DMRJ2GK DMRJ2GK DN AL-37350A DMRJ2GK MI TTJQOD7 DMRJ2GK MN 5-HT 2A receptor (HTR2A) DMRJ2GK MT DTT DMRJ2GK MA Agonist DMRJ2GK RN A novel and selective 5-HT2 receptor agonist with ocular hypotensive activity: (S)-(+)-1-(2-aminopropyl)-8,9-dihydropyrano[3,2-e]indole. J Med Chem. 2003 Sep 11;46(19):4188-95. DMRJ2GK RU https://pubmed.ncbi.nlm.nih.gov/12954071 DMRJ2GK DI DMRJ2GK DMRJ2GK DN AL-37350A DMRJ2GK MI TT0K1SC DMRJ2GK MN 5-HT 2B receptor (HTR2B) DMRJ2GK MT DTT DMRJ2GK MA Agonist DMRJ2GK RN A novel and selective 5-HT2 receptor agonist with ocular hypotensive activity: (S)-(+)-1-(2-aminopropyl)-8,9-dihydropyrano[3,2-e]indole. J Med Chem. 2003 Sep 11;46(19):4188-95. DMRJ2GK RU https://pubmed.ncbi.nlm.nih.gov/12954071 DMRJ2GK DI DMRJ2GK DMRJ2GK DN AL-37350A DMRJ2GK MI TTWJBZ5 DMRJ2GK MN 5-HT 2C receptor (HTR2C) DMRJ2GK MT DTT DMRJ2GK MA Agonist DMRJ2GK RN A novel and selective 5-HT2 receptor agonist with ocular hypotensive activity: (S)-(+)-1-(2-aminopropyl)-8,9-dihydropyrano[3,2-e]indole. J Med Chem. 2003 Sep 11;46(19):4188-95. DMRJ2GK RU https://pubmed.ncbi.nlm.nih.gov/12954071 DM7K360 DI DM7K360 DM7K360 DN AL-408 DM7K360 MI TTS87KH DM7K360 MN Microtubule-associated protein tau (MAPT) DM7K360 MT DTT DM7K360 MA Modulator DM7K360 RN Microtubules (tau) as an emerging therapeutic target: NAP (davunetide). Curr Pharm Des. 2011;17(31):3413-7. DM7K360 RU https://pubmed.ncbi.nlm.nih.gov/21902667 DMLEDHR DI DMLEDHR DMLEDHR DN AL-43 DMLEDHR MI TTKPW01 DMLEDHR MN Androgen receptor messenger RNA (AR mRNA) DMLEDHR MT DTT DMLEDHR MA Inhibitor DMLEDHR RN Nonsteroidal selective glucocorticoid modulators: the effect of C-10 substitution on receptor selectivity and functional potency of 5-allyl-2,5-dih... J Med Chem. 2003 Mar 13;46(6):1016-30. DMLEDHR RU https://pubmed.ncbi.nlm.nih.gov/12620078 DMLEDHR DI DMLEDHR DMLEDHR DN AL-43 DMLEDHR MI TTOZRK6 DMLEDHR MN Glucocorticoid receptor messenger RNA (GCR mRNA) DMLEDHR MT DTT DMLEDHR MA Inhibitor DMLEDHR RN Differentiation of in vitro transcriptional repression and activation profiles of selective glucocorticoid modulators. Bioorg Med Chem Lett. 2004 Apr 5;14(7):1721-7. DMLEDHR RU https://pubmed.ncbi.nlm.nih.gov/15026058 DMLEDHR DI DMLEDHR DMLEDHR DN AL-43 DMLEDHR MI TT26PHO DMLEDHR MN Mineralocorticoid receptor (MR) DMLEDHR MT DTT DMLEDHR MA Inhibitor DMLEDHR RN Nonsteroidal selective glucocorticoid modulators: the effect of C-10 substitution on receptor selectivity and functional potency of 5-allyl-2,5-dih... J Med Chem. 2003 Mar 13;46(6):1016-30. DMLEDHR RU https://pubmed.ncbi.nlm.nih.gov/12620078 DMLEDHR DI DMLEDHR DMLEDHR DN AL-43 DMLEDHR MI TTUV8G9 DMLEDHR MN Progesterone receptor (PGR) DMLEDHR MT DTT DMLEDHR MA Inhibitor DMLEDHR RN Nonsteroidal selective glucocorticoid modulators: the effect of C-10 substitution on receptor selectivity and functional potency of 5-allyl-2,5-dih... J Med Chem. 2003 Mar 13;46(6):1016-30. DMLEDHR RU https://pubmed.ncbi.nlm.nih.gov/12620078 DMHG54F DI DMHG54F DMHG54F DN AL4623 DMHG54F MI TTANPDJ DMHG54F MN Carbonic anhydrase II (CA-II) DMHG54F MT DTT DMHG54F MA Inhibitor DMHG54F RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMHG54F RU https://pubmed.ncbi.nlm.nih.gov/17139284 DM1QJIV DI DM1QJIV DM1QJIV DN AL5300 DM1QJIV MI TTANPDJ DM1QJIV MN Carbonic anhydrase II (CA-II) DM1QJIV MT DTT DM1QJIV MA Inhibitor DM1QJIV RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DM1QJIV RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMSD2U1 DI DMSD2U1 DMSD2U1 DN AL5424 DMSD2U1 MI TTANPDJ DMSD2U1 MN Carbonic anhydrase II (CA-II) DMSD2U1 MT DTT DMSD2U1 MA Inhibitor DMSD2U1 RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMSD2U1 RU https://pubmed.ncbi.nlm.nih.gov/17139284 DM624WO DI DM624WO DM624WO DN AL5927 DM624WO MI TTANPDJ DM624WO MN Carbonic anhydrase II (CA-II) DM624WO MT DTT DM624WO MA Inhibitor DM624WO RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DM624WO RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMPHTX0 DI DMPHTX0 DMPHTX0 DN AL-59640 DMPHTX0 MI TTZ97H5 DMPHTX0 MN Phosphodiesterase 4A (PDE4A) DMPHTX0 MT DTT DMPHTX0 MA Inhibitor DMPHTX0 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1300). DMPHTX0 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1300 DMPHTX0 DI DMPHTX0 DMPHTX0 DN AL-59640 DMPHTX0 MI TTVIAT9 DMPHTX0 MN Phosphodiesterase 4B (PDE4B) DMPHTX0 MT DTT DMPHTX0 MA Modulator DMPHTX0 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1301). DMPHTX0 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1301 DMPHTX0 DI DMPHTX0 DMPHTX0 DN AL-59640 DMPHTX0 MI TTSKMI8 DMPHTX0 MN Phosphodiesterase 4D (PDE4D) DMPHTX0 MT DTT DMPHTX0 MA Modulator DMPHTX0 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1303). DMPHTX0 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1303 DM1JIVR DI DM1JIVR DM1JIVR DN AL6528 DM1JIVR MI TTANPDJ DM1JIVR MN Carbonic anhydrase II (CA-II) DM1JIVR MT DTT DM1JIVR MA Inhibitor DM1JIVR RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DM1JIVR RU https://pubmed.ncbi.nlm.nih.gov/17139284 DM3JNRC DI DM3JNRC DM3JNRC DN AL-6802 DM3JNRC MI TTGKNB4 DM3JNRC MN Epidermal growth factor receptor (EGFR) DM3JNRC MT DTT DM3JNRC MA Modulator DM3JNRC RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1797). DM3JNRC RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1797 DMTXPJI DI DMTXPJI DMTXPJI DN Al7089a DMTXPJI MI TTANPDJ DMTXPJI MN Carbonic anhydrase II (CA-II) DMTXPJI MT DTT DMTXPJI MA Inhibitor DMTXPJI RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMTXPJI RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMRI08C DI DMRI08C DMRI08C DN AL7099A DMRI08C MI TTANPDJ DMRI08C MN Carbonic anhydrase II (CA-II) DMRI08C MT DTT DMRI08C MA Inhibitor DMRI08C RN DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Nucleic Acids Res. 2011 Jan;39(Database issue):D1035-41. DMRI08C RU https://pubmed.ncbi.nlm.nih.gov/21059682 DMG2D4S DI DMG2D4S DMG2D4S DN AL7182 DMG2D4S MI TTANPDJ DMG2D4S MN Carbonic anhydrase II (CA-II) DMG2D4S MT DTT DMG2D4S MA Inhibitor DMG2D4S RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMG2D4S RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMRWLQM DI DMRWLQM DMRWLQM DN AL-8810 DMRWLQM MI TTT2ZAR DMRWLQM MN Prostaglandin F2-alpha receptor (PTGFR) DMRWLQM MT DTT DMRWLQM MA Agonist DMRWLQM RN AL-8810: a novel prostaglandin F2 alpha analog with selective antagonist effects at the prostaglandin F2 alpha (FP) receptor. J Pharmacol Exp Ther. 1999 Sep;290(3):1278-84. DMRWLQM RU https://pubmed.ncbi.nlm.nih.gov/10454504 DMRWUQ5 DI DMRWUQ5 DMRWUQ5 DN Ala(1-naph)-Pro-CN DMRWUQ5 MI TTUA38Z DMRWUQ5 MN Retinoblastoma-binding protein 9 (RBBP9) DMRWUQ5 MT DTT DMRWUQ5 MA Inhibitor DMRWUQ5 RN A high-throughput, multiplexed assay for superfamily-wide profiling of enzyme activity. Nat Chem Biol. 2014 Aug;10(8):656-63. DMRWUQ5 RU https://pubmed.ncbi.nlm.nih.gov/24997602 DMZH4NQ DI DMZH4NQ DMZH4NQ DN Ala11-SRIF-14-amide DMZH4NQ MI TTZ6T9E DMZH4NQ MN Somatostatin receptor type 2 (SSTR2) DMZH4NQ MT DTT DMZH4NQ MA Inhibitor DMZH4NQ RN Replacement of Phe6, Phe7, and Phe11 of D-Trp8-somatostatin-14 with L-pyrazinylalanine. Predicted and observed effects on binding affinities at hSS... J Med Chem. 2005 Jun 16;48(12):4025-30. DMZH4NQ RU https://pubmed.ncbi.nlm.nih.gov/15943475 DMZH4NQ DI DMZH4NQ DMZH4NQ DN Ala11-SRIF-14-amide DMZH4NQ MI TTAE1BR DMZH4NQ MN Somatostatin receptor type 4 (SSTR4) DMZH4NQ MT DTT DMZH4NQ MA Inhibitor DMZH4NQ RN Replacement of Phe6, Phe7, and Phe11 of D-Trp8-somatostatin-14 with L-pyrazinylalanine. Predicted and observed effects on binding affinities at hSS... J Med Chem. 2005 Jun 16;48(12):4025-30. DMZH4NQ RU https://pubmed.ncbi.nlm.nih.gov/15943475 DM9RQ7E DI DM9RQ7E DM9RQ7E DN Ala6-SRIF-14-amide DM9RQ7E MI TTZ6T9E DM9RQ7E MN Somatostatin receptor type 2 (SSTR2) DM9RQ7E MT DTT DM9RQ7E MA Inhibitor DM9RQ7E RN Replacement of Phe6, Phe7, and Phe11 of D-Trp8-somatostatin-14 with L-pyrazinylalanine. Predicted and observed effects on binding affinities at hSS... J Med Chem. 2005 Jun 16;48(12):4025-30. DM9RQ7E RU https://pubmed.ncbi.nlm.nih.gov/15943475 DM9RQ7E DI DM9RQ7E DM9RQ7E DN Ala6-SRIF-14-amide DM9RQ7E MI TTAE1BR DM9RQ7E MN Somatostatin receptor type 4 (SSTR4) DM9RQ7E MT DTT DM9RQ7E MA Inhibitor DM9RQ7E RN Replacement of Phe6, Phe7, and Phe11 of D-Trp8-somatostatin-14 with L-pyrazinylalanine. Predicted and observed effects on binding affinities at hSS... J Med Chem. 2005 Jun 16;48(12):4025-30. DM9RQ7E RU https://pubmed.ncbi.nlm.nih.gov/15943475 DMWF8GN DI DMWF8GN DMWF8GN DN Ala7-SRIF-14-amide DMWF8GN MI TTZ6T9E DMWF8GN MN Somatostatin receptor type 2 (SSTR2) DMWF8GN MT DTT DMWF8GN MA Inhibitor DMWF8GN RN Replacement of Phe6, Phe7, and Phe11 of D-Trp8-somatostatin-14 with L-pyrazinylalanine. Predicted and observed effects on binding affinities at hSS... J Med Chem. 2005 Jun 16;48(12):4025-30. DMWF8GN RU https://pubmed.ncbi.nlm.nih.gov/15943475 DMTWB54 DI DMTWB54 DMTWB54 DN Ala-Pro-Glu DMTWB54 MI TTLD29N DMTWB54 MN Glutamate receptor ionotropic NMDA 1 (NMDAR1) DMTWB54 MT DTT DMTWB54 MA Inhibitor DMTWB54 RN New Gly-Pro-Glu (GPE) analogues: expedite solid-phase synthesis and biological activity. Bioorg Med Chem Lett. 2006 Mar 1;16(5):1392-6. DMTWB54 RU https://pubmed.ncbi.nlm.nih.gov/16321525 DMTWB54 DI DMTWB54 DMTWB54 DN Ala-Pro-Glu DMTWB54 MI TTKJEMQ DMTWB54 MN Glutamate receptor ionotropic NMDA 2A (NMDAR2A) DMTWB54 MT DTT DMTWB54 MA Inhibitor DMTWB54 RN New Gly-Pro-Glu (GPE) analogues: expedite solid-phase synthesis and biological activity. Bioorg Med Chem Lett. 2006 Mar 1;16(5):1392-6. DMTWB54 RU https://pubmed.ncbi.nlm.nih.gov/16321525 DMTWB54 DI DMTWB54 DMTWB54 DN Ala-Pro-Glu DMTWB54 MI TTN9D8E DMTWB54 MN Glutamate receptor ionotropic NMDA 2B (NMDAR2B) DMTWB54 MT DTT DMTWB54 MA Inhibitor DMTWB54 RN New Gly-Pro-Glu (GPE) analogues: expedite solid-phase synthesis and biological activity. Bioorg Med Chem Lett. 2006 Mar 1;16(5):1392-6. DMTWB54 RU https://pubmed.ncbi.nlm.nih.gov/16321525 DMO1ZC2 DI DMO1ZC2 DMO1ZC2 DN ALBAFURAN A DMO1ZC2 MI TTELIN2 DMO1ZC2 MN PTPN1 messenger RNA (PTPN1 mRNA) DMO1ZC2 MT DTT DMO1ZC2 MA Inhibitor DMO1ZC2 RN Protein tyrosine phosphatase 1B inhibitors isolated from Morus bombycis. Bioorg Med Chem Lett. 2009 Dec 1;19(23):6759-61. DMO1ZC2 RU https://pubmed.ncbi.nlm.nih.gov/19846295 DMHIW2L DI DMHIW2L DMHIW2L DN ALBANOL A DMHIW2L MI TTSZLWK DMHIW2L MN Aromatase (CYP19A1) DMHIW2L MT DTT DMHIW2L MA Inhibitor DMHIW2L RN Aromatase inhibitors from Broussonetia papyrifera. J Nat Prod. 2001 Oct;64(10):1286-93. DMHIW2L RU https://pubmed.ncbi.nlm.nih.gov/11678652 DMQXO5G DI DMQXO5G DMQXO5G DN ALD-805 DMQXO5G MI TTNDSF4 DMQXO5G MN Proto-oncogene c-Met (MET) DMQXO5G MT DTT DMQXO5G RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1815). DMQXO5G RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1815 DMWBKH1 DI DMWBKH1 DMWBKH1 DN ALD-806 DMWBKH1 MI TTNDSF4 DMWBKH1 MN Proto-oncogene c-Met (MET) DMWBKH1 MT DTT DMWBKH1 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1815). DMWBKH1 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1815 DMAYGK9 DI DMAYGK9 DMAYGK9 DN ALD-901 DMAYGK9 MI TTEDJN4 DMAYGK9 MN Low-affinity nerve growth factor receptor (NGFR) DMAYGK9 MT DTT DMAYGK9 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1888). DMAYGK9 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1888 DMS80DF DI DMS80DF DMS80DF DN ALDISIN DMS80DF MI TTIDAPM DMS80DF MN ERK activator kinase 1 (MEK1) DMS80DF MT DTT DMS80DF MA Inhibitor DMS80DF RN Aldisine alkaloids from the Philippine sponge Stylissa massa are potent inhibitors of mitogen-activated protein kinase kinase-1 (MEK-1). J Med Chem. 2002 Jan 17;45(2):529-32. DMS80DF RU https://pubmed.ncbi.nlm.nih.gov/11784156 DM83CDK DI DM83CDK DM83CDK DN Alexa-488-telenzepine DM83CDK MI TTOXS3C DM83CDK MN Muscarinic acetylcholine receptor (CHRM) DM83CDK MT DTT DM83CDK MA Antagonist DM83CDK RN Formation and dissociation of M1 muscarinic receptor dimers seen by total internal reflection fluorescence imaging of single molecules. Proc Natl Acad Sci U S A. 2010 Feb 9;107(6):2693-8. DM83CDK RU https://pubmed.ncbi.nlm.nih.gov/20133736 DM53KRA DI DM53KRA DM53KRA DN ALF-421 DM53KRA MI TTG043C DM53KRA MN Tumor necrosis factor receptor type I (TNF-R1) DM53KRA MT DTT DM53KRA MA Modulator DM53KRA RN Secretion of a TNFR:Fc fusion protein following pulmonary administration of pseudotyped adeno-associated virus vectors. J Virol. 2004 Nov;78(22):12355-65. DM53KRA RU https://pubmed.ncbi.nlm.nih.gov/15507622 DMI4OTW DI DMI4OTW DMI4OTW DN ALFAXALONE DMI4OTW MI TTNJYV2 DMI4OTW MN Gamma-aminobutyric acid receptor (GAR) DMI4OTW MT DTT DMI4OTW MA Inhibitor DMI4OTW RN Propofol analogues. Synthesis, relationships between structure and affinity at GABAA receptor in rat brain, and differential electrophysiological p... J Med Chem. 1998 May 21;41(11):1846-54. DMI4OTW RU https://pubmed.ncbi.nlm.nih.gov/9599235 DMWMIRL DI DMWMIRL DMWMIRL DN Alisporivir DMWMIRL MI TTS41ER DMWMIRL MN HUMAN cyclophilin A (CYPA) DMWMIRL MT DTT DMWMIRL MA Inhibitor DMWMIRL RN Therapeutic options for the 2019 novel coronavirus (2019-nCoV). Nat Rev Drug Discov. 2020 Mar;19(3):149-150. DMWMIRL RU https://pubmed.ncbi.nlm.nih.gov/32127666 DM3DERI DI DM3DERI DM3DERI DN alkyl glycerol phosphate 18:1 DM3DERI MI TTABCJ6 DM3DERI MN Lysophosphatidic acid receptor 5 (LPAR5) DM3DERI MT DTT DM3DERI MA Agonist DM3DERI RN Unique ligand selectivity of the GPR92/LPA5 lysophosphatidate receptor indicates role in human platelet activation. J Biol Chem. 2009 Jun 19;284(25):17304-19. DM3DERI RU https://pubmed.ncbi.nlm.nih.gov/19366702 DMM19AO DI DMM19AO DMM19AO DN alkyl OMPT DMM19AO MI TTE2YJR DMM19AO MN Lysophosphatidate-3 receptor (LPAR3) DMM19AO MT DTT DMM19AO MA Agonist DMM19AO RN Phosphorothioate analogues of alkyl lysophosphatidic acid as LPA3 receptor-selective agonists. ChemMedChem. 2006 Mar;1(3):376-83. DMM19AO RU https://pubmed.ncbi.nlm.nih.gov/16892372 DMM19AO DI DMM19AO DMM19AO DN alkyl OMPT DMM19AO MI TTQ6S1K DMM19AO MN Lysophosphatidic acid receptor 1 (LPAR1) DMM19AO MT DTT DMM19AO MA Agonist DMM19AO RN Phosphorothioate analogues of alkyl lysophosphatidic acid as LPA3 receptor-selective agonists. ChemMedChem. 2006 Mar;1(3):376-83. DMM19AO RU https://pubmed.ncbi.nlm.nih.gov/16892372 DMQH481 DI DMQH481 DMQH481 DN alkylbenzene sulfonate DMQH481 MI TTZ8EM9 DMQH481 MN Glycine receptor (GlyR) DMQH481 MT DTT DMQH481 RN Selective actions of a detergent on ligand-gated ion channels expressed in Xenopus oocytes. J Pharmacol Exp Ther. 1998 Jan;284(1):32-6. DMQH481 RU https://pubmed.ncbi.nlm.nih.gov/9435157 DMSOJ6H DI DMSOJ6H DMSOJ6H DN ALLICIN DMSOJ6H MI TT2SUAQ DMSOJ6H MN Cysteine protease (CYP) DMSOJ6H MT DTT DMSOJ6H MA Inhibitor DMSOJ6H RN Allicin and derivates are cysteine protease inhibitors with antiparasitic activity. Bioorg Med Chem Lett. 2010 Sep 15;20(18):5541-3. DMSOJ6H RU https://pubmed.ncbi.nlm.nih.gov/20692829 DM05AYE DI DM05AYE DM05AYE DN alloswitch-1 DM05AYE MI TTHS256 DM05AYE MN Metabotropic glutamate receptor 5 (mGluR5) DM05AYE MT DTT DM05AYE MA Modulator (allosteric modulator) DM05AYE RN An allosteric modulator to control endogenous G protein-coupled receptors with light. Nat Chem Biol. 2014 Oct;10(10):813-5. DM05AYE RU https://pubmed.ncbi.nlm.nih.gov/25173999 DM7U2BE DI DM7U2BE DM7U2BE DN Alloxazine DM7U2BE MI TTM2AOE DM7U2BE MN Adenosine A2a receptor (ADORA2A) DM7U2BE MT DTT DM7U2BE MA Inhibitor DM7U2BE RN 2-n-Butyl-9-methyl-8-[1,2,3]triazol-2-yl-9H-purin-6-ylamine and analogues as A2A adenosine receptor antagonists. Design, synthesis, and pharmacolog... J Med Chem. 2005 Nov 3;48(22):6887-96. DM7U2BE RU https://pubmed.ncbi.nlm.nih.gov/16250647 DM7U2BE DI DM7U2BE DM7U2BE DN Alloxazine DM7U2BE MI TTNE7KG DM7U2BE MN Adenosine A2b receptor (ADORA2B) DM7U2BE MT DTT DM7U2BE MA Inhibitor DM7U2BE RN 2-n-Butyl-9-methyl-8-[1,2,3]triazol-2-yl-9H-purin-6-ylamine and analogues as A2A adenosine receptor antagonists. Design, synthesis, and pharmacolog... J Med Chem. 2005 Nov 3;48(22):6887-96. DM7U2BE RU https://pubmed.ncbi.nlm.nih.gov/16250647 DMM2R1N DI DMM2R1N DMM2R1N DN all-trans-4-oxo-retinoic acid DMM2R1N MI TT2NUT5 DMM2R1N MN Adrenergic receptor alpha-2C (ADRA2C) DMM2R1N MT DTT DMM2R1N MA Antagonist DMM2R1N RN Discovery of new tetracyclic tetrahydrofuran derivatives as potential broad-spectrum psychotropic agents. J Med Chem. 2005 Mar 24;48(6):1709-12. DMM2R1N RU https://pubmed.ncbi.nlm.nih.gov/15771415 DMM2R1N DI DMM2R1N DMM2R1N DN all-trans-4-oxo-retinoic acid DMM2R1N MI TTGB2LZ DMM2R1N MN RAR-related orphan receptor-beta (RORB) DMM2R1N MT DTT DMM2R1N MA Antagonist DMM2R1N RN All-trans retinoic acid is a ligand for the orphan nuclear receptor ROR beta. Nat Struct Biol. 2003 Oct;10(10):820-5. DMM2R1N RU https://pubmed.ncbi.nlm.nih.gov/12958591 DM6CEVB DI DM6CEVB DM6CEVB DN All-trans-retinal DM6CEVB MI DE2JP1Y DM6CEVB MN Aldehyde dehydrogenase 1 (ALDH1) DM6CEVB MT DME DM6CEVB MA Metabolism DM6CEVB RN Retinoic acid biosynthesis catalyzed by retinal dehydrogenases relies on a rate-limiting conformational transition associated with substrate recognition. Chem Biol Interact. 2013 Feb 25;202(1-3):78-84. DM6CEVB RU https://www.ncbi.nlm.nih.gov/pubmed/?term=23220587 DM6CEVB DI DM6CEVB DM6CEVB DN All-trans-retinal DM6CEVB MI TT8SJGB DM6CEVB MN Cyclic nucleotide-gated channel alpha-2 (CNGA2) DM6CEVB MT DTT DM6CEVB MA Inhibitor (gating inhibitor) DM6CEVB RN All-trans-retinal shuts down rod cyclic nucleotide-gated ion channels: a novel role for photoreceptor retinoids in the response to bright light Proc Natl Acad Sci U S A. 2002 Jun 11;99(12):8372-7. DM6CEVB RU https://pubmed.ncbi.nlm.nih.gov/12034887 DM8R5AS DI DM8R5AS DM8R5AS DN Allyl 4-(2-oxohexadecanamido)butanoate DM8R5AS MI TTT1JVS DM8R5AS MN Cytosolic phospholipase A2 (GIVA cPLA2) DM8R5AS MT DTT DM8R5AS MA Inhibitor DM8R5AS RN Structure-activity relationships of natural and non-natural amino acid-based amide and 2-oxoamide inhibitors of human phospholipase A(2) enzymes. Bioorg Med Chem. 2008 Dec 15;16(24):10257-69. DM8R5AS RU https://pubmed.ncbi.nlm.nih.gov/18993078 DMYNKLR DI DMYNKLR DMYNKLR DN Allyl 4-(aminosulfonyl)benzoate DMYNKLR MI TTANPDJ DMYNKLR MN Carbonic anhydrase II (CA-II) DMYNKLR MT DTT DMYNKLR MA Inhibitor DMYNKLR RN Synthesis and structure-activity relationships of novel benzene sulfonamides with potent binding affinity for bovine carbonic anhydrase II. Bioorg Med Chem Lett. 2005 Dec 15;15(24):5429-33. DMYNKLR RU https://pubmed.ncbi.nlm.nih.gov/16213706 DMNFGRV DI DMNFGRV DMNFGRV DN Allylamines DMNFGRV MI TTE14XG DMNFGRV MN Squalene monooxygenase (SQLE) DMNFGRV MT DTT DMNFGRV MA Inhibitor DMNFGRV RN Differential inhibition of fungal amd mammalian squalene epoxidases by the benzylamine SDZ SBA 586 in comparison with the allylamine terbinafine. Arch Biochem Biophys. 1997 Apr 15;340(2):265-9. DMNFGRV RU https://pubmed.ncbi.nlm.nih.gov/9143330 DMJWZB3 DI DMJWZB3 DMJWZB3 DN Allylcarbamic Acid Biphenyl-3-yl Ester DMJWZB3 MI TTDP1UC DMJWZB3 MN Fatty acid amide hydrolase (FAAH) DMJWZB3 MT DTT DMJWZB3 MA Inhibitor DMJWZB3 RN Synthesis and quantitative structure-activity relationship of fatty acid amide hydrolase inhibitors: modulation at the N-portion of biphenyl-3-yl a... J Med Chem. 2008 Jun 26;51(12):3487-98. DMJWZB3 RU https://pubmed.ncbi.nlm.nih.gov/18507372 DM1VHCL DI DM1VHCL DM1VHCL DN Allyl-trimethyl-ammonium DM1VHCL MI TT1RS9F DM1VHCL MN Acetylcholinesterase (AChE) DM1VHCL MT DTT DM1VHCL MA Inhibitor DM1VHCL RN Structure-based alignment and comparative molecular field analysis of acetylcholinesterase inhibitors. J Med Chem. 1996 Dec 20;39(26):5064-71. DM1VHCL RU https://pubmed.ncbi.nlm.nih.gov/8978837 DMY1OG7 DI DMY1OG7 DMY1OG7 DN ALM-301 DMY1OG7 MI TTWTSCV DMY1OG7 MN RAC-alpha serine/threonine-protein kinase (AKT1) DMY1OG7 MT DTT DMY1OG7 MA Inhibitor DMY1OG7 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1479). DMY1OG7 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1479 DMPTY8S DI DMPTY8S DMPTY8S DN Aloe-emodin DMPTY8S MI TTB6UM0 DMPTY8S MN Fatty aldehyde dehydrogenase (ALDH3A2) DMPTY8S MT DTT DMPTY8S MA Inhibitor DMPTY8S RN Elgonica-Dimers A and B, Two Potent Alcohol Metabolism Inhibitory Constituents of Aloe arborescens J. Nat. Prod. 60(11):1180-1182 (1997). DMPTY8S RU http://pubs.acs.org/doi/abs/10.1021/np9703104 DM7HGX8 DI DM7HGX8 DM7HGX8 DN aloisine DM7HGX8 MI TT7HF4W DM7HGX8 MN Cyclin-dependent kinase 2 (CDK2) DM7HGX8 MT DTT DM7HGX8 MA Inhibitor DM7HGX8 RN Identification of binding specificity-determining features in protein families. J Med Chem. 2012 Mar 8;55(5):1926-39. DM7HGX8 RU https://pubmed.ncbi.nlm.nih.gov/22289061 DM7HGX8 DI DM7HGX8 DM7HGX8 DN aloisine DM7HGX8 MI TTTEFBV DM7HGX8 MN Focal adhesion kinase 2 (PTK2B) DM7HGX8 MT DTT DM7HGX8 MA Inhibitor DM7HGX8 RN Identification of binding specificity-determining features in protein families. J Med Chem. 2012 Mar 8;55(5):1926-39. DM7HGX8 RU https://pubmed.ncbi.nlm.nih.gov/22289061 DM7HGX8 DI DM7HGX8 DM7HGX8 DN aloisine DM7HGX8 MI TTUMHT8 DM7HGX8 MN Tyrosine-protein kinase ZAP-70 (ZAP-70) DM7HGX8 MT DTT DM7HGX8 MA Inhibitor DM7HGX8 RN Identification of binding specificity-determining features in protein families. J Med Chem. 2012 Mar 8;55(5):1926-39. DM7HGX8 RU https://pubmed.ncbi.nlm.nih.gov/22289061 DM5U1LN DI DM5U1LN DM5U1LN DN aloisine A DM5U1LN MI TTAMQ62 DM5U1LN MN Cyclin A2 (CCNA2) DM5U1LN MT DTT DM5U1LN MA Inhibitor DM5U1LN RN Aloisines, a new family of CDK/GSK-3 inhibitors. SAR study, crystal structure in complex with CDK2, enzyme selectivity, and cellular effects. J Med Chem. 2003 Jan 16;46(2):222-36. DM5U1LN RU https://pubmed.ncbi.nlm.nih.gov/12519061 DM5U1LN DI DM5U1LN DM5U1LN DN aloisine A DM5U1LN MI TTH6V3D DM5U1LN MN Cyclin-dependent kinase 1 (CDK1) DM5U1LN MT DTT DM5U1LN MA Inhibitor DM5U1LN RN Aloisines, a new family of CDK/GSK-3 inhibitors. SAR study, crystal structure in complex with CDK2, enzyme selectivity, and cellular effects. J Med Chem. 2003 Jan 16;46(2):222-36. DM5U1LN RU https://pubmed.ncbi.nlm.nih.gov/12519061 DM5U1LN DI DM5U1LN DM5U1LN DN aloisine A DM5U1LN MI TT7HF4W DM5U1LN MN Cyclin-dependent kinase 2 (CDK2) DM5U1LN MT DTT DM5U1LN MA Inhibitor DM5U1LN RN Aloisines, a new family of CDK/GSK-3 inhibitors. SAR study, crystal structure in complex with CDK2, enzyme selectivity, and cellular effects. J Med Chem. 2003 Jan 16;46(2):222-36. DM5U1LN RU https://pubmed.ncbi.nlm.nih.gov/12519061 DM5U1LN DI DM5U1LN DM5U1LN DN aloisine A DM5U1LN MI TTL4Q97 DM5U1LN MN Cyclin-dependent kinase 5 (CDK5) DM5U1LN MT DTT DM5U1LN MA Inhibitor DM5U1LN RN Aloisines, a new family of CDK/GSK-3 inhibitors. SAR study, crystal structure in complex with CDK2, enzyme selectivity, and cellular effects. J Med Chem. 2003 Jan 16;46(2):222-36. DM5U1LN RU https://pubmed.ncbi.nlm.nih.gov/12519061 DM5U1LN DI DM5U1LN DM5U1LN DN aloisine A DM5U1LN MI TTCEJ4F DM5U1LN MN G1/S-specific cyclin-E1 (CCNE1) DM5U1LN MT DTT DM5U1LN MA Inhibitor DM5U1LN RN Aloisines, a new family of CDK/GSK-3 inhibitors. SAR study, crystal structure in complex with CDK2, enzyme selectivity, and cellular effects. J Med Chem. 2003 Jan 16;46(2):222-36. DM5U1LN RU https://pubmed.ncbi.nlm.nih.gov/12519061 DM5U1LN DI DM5U1LN DM5U1LN DN aloisine A DM5U1LN MI TTQWAU1 DM5U1LN MN GSK3A messenger RNA (GSK3A mRNA) DM5U1LN MT DTT DM5U1LN MA Inhibitor DM5U1LN RN Aloisines, a new family of CDK/GSK-3 inhibitors. SAR study, crystal structure in complex with CDK2, enzyme selectivity, and cellular effects. J Med Chem. 2003 Jan 16;46(2):222-36. DM5U1LN RU https://pubmed.ncbi.nlm.nih.gov/12519061 DMHRME4 DI DMHRME4 DMHRME4 DN Alpha,beta-methylene-dATP DMHRME4 MI TTIU7X1 DMHRME4 MN Herpes simplex virus DNA polymerase UL30 (HSV UL30) DMHRME4 MT DTT DMHRME4 MA Inhibitor DMHRME4 RN Alpha,beta-methylene-2'-deoxynucleoside 5'-triphosphates as noncleavable substrates for DNA polymerases: isolation, characterization, and stability... J Med Chem. 2008 Oct 23;51(20):6460-70. DMHRME4 RU https://pubmed.ncbi.nlm.nih.gov/18811136 DMJI8TX DI DMJI8TX DMJI8TX DN Alpha,beta-methylene-dCTP DMJI8TX MI TTIU7X1 DMJI8TX MN Herpes simplex virus DNA polymerase UL30 (HSV UL30) DMJI8TX MT DTT DMJI8TX MA Inhibitor DMJI8TX RN Alpha,beta-methylene-2'-deoxynucleoside 5'-triphosphates as noncleavable substrates for DNA polymerases: isolation, characterization, and stability... J Med Chem. 2008 Oct 23;51(20):6460-70. DMJI8TX RU https://pubmed.ncbi.nlm.nih.gov/18811136 DMPZS80 DI DMPZS80 DMPZS80 DN Alpha,beta-methylene-dGTP DMPZS80 MI TTIU7X1 DMPZS80 MN Herpes simplex virus DNA polymerase UL30 (HSV UL30) DMPZS80 MT DTT DMPZS80 MA Inhibitor DMPZS80 RN Alpha,beta-methylene-2'-deoxynucleoside 5'-triphosphates as noncleavable substrates for DNA polymerases: isolation, characterization, and stability... J Med Chem. 2008 Oct 23;51(20):6460-70. DMPZS80 RU https://pubmed.ncbi.nlm.nih.gov/18811136 DMPAHJF DI DMPAHJF DMPAHJF DN Alpha,beta-methylene-dTTP DMPAHJF MI TTIU7X1 DMPAHJF MN Herpes simplex virus DNA polymerase UL30 (HSV UL30) DMPAHJF MT DTT DMPAHJF MA Inhibitor DMPAHJF RN Alpha,beta-methylene-2'-deoxynucleoside 5'-triphosphates as noncleavable substrates for DNA polymerases: isolation, characterization, and stability... J Med Chem. 2008 Oct 23;51(20):6460-70. DMPAHJF RU https://pubmed.ncbi.nlm.nih.gov/18811136 DMLGMTQ DI DMLGMTQ DMLGMTQ DN alpha.beta-methylene-2-thio-UDP DMLGMTQ MI TT72OKI DMLGMTQ MN P2Y purinoceptor 14 (P2RY14) DMLGMTQ MT DTT DMLGMTQ MA Agonist DMLGMTQ RN Human P2Y(14) receptor agonists: truncation of the hexose moiety of uridine-5'-diphosphoglucose and its replacement with alkyl and aryl groups. J Med Chem. 2010 Jan 14;53(1):471-80. DMLGMTQ RU https://pubmed.ncbi.nlm.nih.gov/19902968 DM257WX DI DM257WX DM257WX DN alpha3IA DM257WX MI TTBMV1G DM257WX MN GABA(A) receptor alpha-2 (GABRA2) DM257WX MT DTT DM257WX MA Modulator (allosteric modulator) DM257WX RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 405). DM257WX RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=405 DM257WX DI DM257WX DM257WX DN alpha3IA DM257WX MI TT37EDJ DM257WX MN GABA(A) receptor alpha-3 (GABRA3) DM257WX MT DTT DM257WX MA Modulator (allosteric modulator) DM257WX RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 406). DM257WX RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=406 DM257WX DI DM257WX DM257WX DN alpha3IA DM257WX MI TTNZPQ1 DM257WX MN GABA(A) receptor alpha-5 (GABRA5) DM257WX MT DTT DM257WX MA Modulator (allosteric modulator) DM257WX RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 408). DM257WX RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=408 DM257WX DI DM257WX DM257WX DN alpha3IA DM257WX MI TTEX6LM DM257WX MN GABA(A) receptor gamma-3 (GABRG3) DM257WX MT DTT DM257WX MA Modulator (allosteric modulator) DM257WX RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 415). DM257WX RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=415 DMTU5QR DI DMTU5QR DMTU5QR DN alpha5IA DMTU5QR MI TTBMV1G DMTU5QR MN GABA(A) receptor alpha-2 (GABRA2) DMTU5QR MT DTT DMTU5QR MA Modulator (allosteric modulator) DMTU5QR RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 405). DMTU5QR RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=405 DMTU5QR DI DMTU5QR DMTU5QR DN alpha5IA DMTU5QR MI TT37EDJ DMTU5QR MN GABA(A) receptor alpha-3 (GABRA3) DMTU5QR MT DTT DMTU5QR MA Modulator (allosteric modulator) DMTU5QR RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 406). DMTU5QR RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=406 DMTU5QR DI DMTU5QR DMTU5QR DN alpha5IA DMTU5QR MI TTNZPQ1 DMTU5QR MN GABA(A) receptor alpha-5 (GABRA5) DMTU5QR MT DTT DMTU5QR MA Modulator (allosteric modulator) DMTU5QR RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 408). DMTU5QR RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=408 DMTU5QR DI DMTU5QR DMTU5QR DN alpha5IA DMTU5QR MI TTEX6LM DMTU5QR MN GABA(A) receptor gamma-3 (GABRG3) DMTU5QR MT DTT DMTU5QR MA Modulator (allosteric modulator) DMTU5QR RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 415). DMTU5QR RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=415 DMND5EU DI DMND5EU DMND5EU DN Alpha-7-Deoxyhomonojirimycin DMND5EU MI TTLPC70 DMND5EU MN Lysosomal alpha-glucosidase (GAA) DMND5EU MT DTT DMND5EU MA Inhibitor DMND5EU RN New polyhydroxylated pyrrolidine, piperidine, and pyrrolizidine alkaloids from Scilla sibirica. J Nat Prod. 2002 Dec;65(12):1875-81. DMND5EU RU https://pubmed.ncbi.nlm.nih.gov/12502331 DMHV14R DI DMHV14R DMHV14R DN Alpha-acarviosinyl-(1-->7)-3-alpha-D-glucopyranosylpropen DMHV14R MI TTCGSZ4 DMHV14R MN Pancreatic alpha-amylase (AMY2A) DMHV14R MT DTT DMHV14R MA Inhibitor DMHV14R RN Enzymatic synthesis of a selective inhibitor for alpha-glucosidases: alpha-acarviosinyl-(1-->9)-3-alpha-D-glucopyranosylpropen. J Agric Food Chem. 2008 Jul 9;56(13):5324-30. DMHV14R RU https://pubmed.ncbi.nlm.nih.gov/18553919 DM4IXUQ DI DM4IXUQ DM4IXUQ DN Alpha-acarviosinyl-(1-->9)-3-alpha-D-glucopyranosylpropen DM4IXUQ MI TTCGSZ4 DM4IXUQ MN Pancreatic alpha-amylase (AMY2A) DM4IXUQ MT DTT DM4IXUQ MA Inhibitor DM4IXUQ RN Enzymatic synthesis of a selective inhibitor for alpha-glucosidases: alpha-acarviosinyl-(1-->9)-3-alpha-D-glucopyranosylpropen. J Agric Food Chem. 2008 Jul 9;56(13):5324-30. DM4IXUQ RU https://pubmed.ncbi.nlm.nih.gov/18553919 DMW1LF0 DI DMW1LF0 DMW1LF0 DN Alpha-Aminobutyric Acid DMW1LF0 MI TT3DQUT DMW1LF0 MN Bacterial Lantibiotic mersacidin (Bact glmM) DMW1LF0 MT DTT DMW1LF0 MA Inhibitor DMW1LF0 RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMW1LF0 RU https://pubmed.ncbi.nlm.nih.gov/17139284 DM9GXFJ DI DM9GXFJ DM9GXFJ DN Alpha-Aminoisobutyric Acid DM9GXFJ MI TTA7YIZ DM9GXFJ MN Corticoliberin (CRH) DM9GXFJ MT DTT DM9GXFJ MA Inhibitor DM9GXFJ RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DM9GXFJ RU https://pubmed.ncbi.nlm.nih.gov/10592235 DM9GXFJ DI DM9GXFJ DM9GXFJ DN Alpha-Aminoisobutyric Acid DM9GXFJ MI TT64REZ DM9GXFJ MN Neuropeptide Y (NPY) DM9GXFJ MT DTT DM9GXFJ MA Inhibitor DM9GXFJ RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DM9GXFJ RU https://pubmed.ncbi.nlm.nih.gov/10592235 DMRGFEM DI DMRGFEM DMRGFEM DN alphabeta-methyleneADP DMRGFEM MI TTK0O6Y DMRGFEM MN Ecto-5'-nucleotidase (CD73) DMRGFEM MT DTT DMRGFEM MA Inhibitor DMRGFEM RN 5'-Nucleotidase from smooth muscle of small intestine and from brain. Inhibition of nucleotides. Biochemistry. 1975 Jun 3;14(11):2362-6. DMRGFEM RU https://pubmed.ncbi.nlm.nih.gov/1169962 DMRGFEM DI DMRGFEM DMRGFEM DN alphabeta-methyleneADP DMRGFEM MI TTUTN1I DMRGFEM MN Human Deoxyribonucleic acid (hDNA) DMRGFEM MT DTT DMRGFEM MA Inhibitor DMRGFEM RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMRGFEM RU https://pubmed.ncbi.nlm.nih.gov/17139284 DM96EJ1 DI DM96EJ1 DM96EJ1 DN alpha-conotoxin AuIB DM96EJ1 MI TTH18TF DM96EJ1 MN Muscarinic acetylcholine receptor M5 (CHRM5) DM96EJ1 MT DTT DM96EJ1 MA Antagonist DM96EJ1 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 467). DM96EJ1 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=467 DMHO634 DI DMHO634 DMHO634 DN alpha-conotoxin GI DMHO634 MI TTH18TF DMHO634 MN Muscarinic acetylcholine receptor M5 (CHRM5) DMHO634 MT DTT DMHO634 MA Antagonist DMHO634 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 467). DMHO634 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=467 DM1QOY0 DI DM1QOY0 DM1QOY0 DN alpha-conotoxin PnIA DM1QOY0 MI TTH18TF DM1QOY0 MN Muscarinic acetylcholine receptor M5 (CHRM5) DM1QOY0 MT DTT DM1QOY0 MA Antagonist DM1QOY0 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 467). DM1QOY0 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=467 DM1QOY0 DI DM1QOY0 DM1QOY0 DN alpha-conotoxin PnIA DM1QOY0 MI TTH2QRX DM1QOY0 MN Neuronal acetylcholine receptor alpha-5 (CHRNA5) DM1QOY0 MT DTT DM1QOY0 MA Antagonist DM1QOY0 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 466). DM1QOY0 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=466 DM6VH7A DI DM6VH7A DM6VH7A DN Alpha-D-Fucose DM6VH7A MI TTSZDQU DM6VH7A MN Lactotransferrin (LTF) DM6VH7A MT DTT DM6VH7A MA Inhibitor DM6VH7A RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DM6VH7A RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMD2TPA DI DMD2TPA DMD2TPA DN Alpha-D-Glucopyranosyl-2-Carboxylic Acid Amide DMD2TPA MI TTZHY6R DMD2TPA MN Glycogen phosphorylase muscle form (GP) DMD2TPA MT DTT DMD2TPA MA Inhibitor DMD2TPA RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMD2TPA RU https://pubmed.ncbi.nlm.nih.gov/17139284 DM1X3VQ DI DM1X3VQ DM1X3VQ DN Alpha-D-glucose DM1X3VQ MI DE63NYG DM1X3VQ MN Galactose mutarotase (GALM) DM1X3VQ MT DME DM1X3VQ MA Metabolism DM1X3VQ RN Identification and characterisation of human aldose 1-epimerase. FEBS Lett. 2003 May 22;543(1-3):21-4. DM1X3VQ RU https://www.ncbi.nlm.nih.gov/pubmed/?term=12753898 DMU36HT DI DMU36HT DMU36HT DN Alpha-D-Glucose-1-Phosphate DMU36HT MI TTZHY6R DMU36HT MN Glycogen phosphorylase muscle form (GP) DMU36HT MT DTT DMU36HT MA Inhibitor DMU36HT RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMU36HT RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMU36HT DI DMU36HT DMU36HT DN Alpha-D-Glucose-1-Phosphate DMU36HT MI TTLP3GX DMU36HT MN Pseudomonas Phosphomannomutase/phosphoglucomutase (Pseudo algC) DMU36HT MT DTT DMU36HT MA Inhibitor DMU36HT RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMU36HT RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMR0EVN DI DMR0EVN DMR0EVN DN Alpha-D-Glucose-6-Phosphate DMR0EVN MI TTFBNVI DMR0EVN MN Aldose reductase (AKR1B1) DMR0EVN MT DTT DMR0EVN MA Inhibitor DMR0EVN RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMR0EVN RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMR0EVN DI DMR0EVN DMR0EVN DN Alpha-D-Glucose-6-Phosphate DMR0EVN MI TTC67I0 DMR0EVN MN Bacterial Glucosamine-6-phosphate synthase (Bact glmS) DMR0EVN MT DTT DMR0EVN MA Inhibitor DMR0EVN RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMR0EVN RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMR0EVN DI DMR0EVN DMR0EVN DN Alpha-D-Glucose-6-Phosphate DMR0EVN MI TTZHY6R DMR0EVN MN Glycogen phosphorylase muscle form (GP) DMR0EVN MT DTT DMR0EVN MA Inhibitor DMR0EVN RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMR0EVN RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMR0EVN DI DMR0EVN DMR0EVN DN Alpha-D-Glucose-6-Phosphate DMR0EVN MI TTLP3GX DMR0EVN MN Pseudomonas Phosphomannomutase/phosphoglucomutase (Pseudo algC) DMR0EVN MT DTT DMR0EVN MA Inhibitor DMR0EVN RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMR0EVN RU https://pubmed.ncbi.nlm.nih.gov/17139284 DM6ZTOW DI DM6ZTOW DM6ZTOW DN Alpha-dihydroaldosterone DM6ZTOW MI DEB3CV1 DM6ZTOW MN UDP-glucuronosyltransferase 2B7 (UGT2B7) DM6ZTOW MT DME DM6ZTOW MA Metabolism DM6ZTOW RN Human uridine diphosphate-glucuronosyltransferase UGT2B7 conjugates mineralocorticoid and glucocorticoid metabolites. Endocrinology. 2003 Jun;144(6):2659-68. DM6ZTOW RU https://www.ncbi.nlm.nih.gov/pubmed/?term=12746330 DMF5DLW DI DMF5DLW DMF5DLW DN Alpha-D-Mannose DMF5DLW MI TTQICM2 DMF5DLW MN ADAM metallopeptidase 33 (ADAM33) DMF5DLW MT DTT DMF5DLW MA Inhibitor DMF5DLW RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMF5DLW RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMF5DLW DI DMF5DLW DMF5DLW DN Alpha-D-Mannose DMF5DLW MI TTIS03D DMF5DLW MN Alpha-galactosidase A (GLA) DMF5DLW MT DTT DMF5DLW MA Inhibitor DMF5DLW RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMF5DLW RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMF5DLW DI DMF5DLW DMF5DLW DN Alpha-D-Mannose DMF5DLW MI TT4QPUL DMF5DLW MN Antithrombin-III (ATIII) DMF5DLW MT DTT DMF5DLW MA Inhibitor DMF5DLW RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMF5DLW RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMF5DLW DI DMF5DLW DMF5DLW DN Alpha-D-Mannose DMF5DLW MI TT2OUI9 DMF5DLW MN Beta-2-glycoprotein 1 (APOH) DMF5DLW MT DTT DMF5DLW MA Inhibitor DMF5DLW RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMF5DLW RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMF5DLW DI DMF5DLW DMF5DLW DN Alpha-D-Mannose DMF5DLW MI TTPT2QI DMF5DLW MN Cathepsin D (CTSD) DMF5DLW MT DTT DMF5DLW MA Inhibitor DMF5DLW RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMF5DLW RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMF5DLW DI DMF5DLW DMF5DLW DN Alpha-D-Mannose DMF5DLW MI TTEB0GD DMF5DLW MN Cholinesterase (BCHE) DMF5DLW MT DTT DMF5DLW MA Inhibitor DMF5DLW RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMF5DLW RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMF5DLW DI DMF5DLW DMF5DLW DN Alpha-D-Mannose DMF5DLW MI TTI2S1D DMF5DLW MN Cytotoxic T-lymphocyte protein 4 (CTLA-4) DMF5DLW MT DTT DMF5DLW MA Inhibitor DMF5DLW RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMF5DLW RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMF5DLW DI DMF5DLW DMF5DLW DN Alpha-D-Mannose DMF5DLW MI TTYWGOJ DMF5DLW MN Deoxyribonuclease I (DNASE1) DMF5DLW MT DTT DMF5DLW MA Inhibitor DMF5DLW RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMF5DLW RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMF5DLW DI DMF5DLW DMF5DLW DN Alpha-D-Mannose DMF5DLW MI TTDIGC1 DMF5DLW MN Dipeptidyl peptidase 4 (DPP-4) DMF5DLW MT DTT DMF5DLW MA Inhibitor DMF5DLW RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMF5DLW RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMF5DLW DI DMF5DLW DMF5DLW DN Alpha-D-Mannose DMF5DLW MI TTFC29G DMF5DLW MN Glycoprotein hormones alpha (CGA) DMF5DLW MT DTT DMF5DLW MA Inhibitor DMF5DLW RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMF5DLW RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMF5DLW DI DMF5DLW DMF5DLW DN Alpha-D-Mannose DMF5DLW MI TT8XSKJ DMF5DLW MN Heparin cofactor II (SERPIND1) DMF5DLW MT DTT DMF5DLW MA Inhibitor DMF5DLW RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMF5DLW RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMF5DLW DI DMF5DLW DMF5DLW DN Alpha-D-Mannose DMF5DLW MI TTDGEC0 DMF5DLW MN Immunoglobulin epsilon Fc receptor gamma (FCERG) DMF5DLW MT DTT DMF5DLW MA Inhibitor DMF5DLW RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMF5DLW RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMF5DLW DI DMF5DLW DMF5DLW DN Alpha-D-Mannose DMF5DLW MI TTF4CAM DMF5DLW MN Influenza Hemagglutinin (Influ HA) DMF5DLW MT DTT DMF5DLW MA Inhibitor DMF5DLW RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMF5DLW RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMF5DLW DI DMF5DLW DMF5DLW DN Alpha-D-Mannose DMF5DLW MI TT50QJ3 DMF5DLW MN Influenza Neuraminidase (Influ NA) DMF5DLW MT DTT DMF5DLW MA Inhibitor DMF5DLW RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMF5DLW RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMF5DLW DI DMF5DLW DMF5DLW DN Alpha-D-Mannose DMF5DLW MI TTHRID2 DMF5DLW MN Insulin-like growth factor I receptor (IGF1R) DMF5DLW MT DTT DMF5DLW MA Inhibitor DMF5DLW RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMF5DLW RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMF5DLW DI DMF5DLW DMF5DLW DN Alpha-D-Mannose DMF5DLW MI TT0E5SK DMF5DLW MN Interleukin 6 receptor (IL6R) DMF5DLW MT DTT DMF5DLW MA Inhibitor DMF5DLW RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMF5DLW RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMF5DLW DI DMF5DLW DMF5DLW DN Alpha-D-Mannose DMF5DLW MI TTA0OSE DMF5DLW MN Lactase-phlorizin hydrolase (LCT) DMF5DLW MT DTT DMF5DLW MA Inhibitor DMF5DLW RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMF5DLW RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMF5DLW DI DMF5DLW DMF5DLW DN Alpha-D-Mannose DMF5DLW MI TTSZDQU DMF5DLW MN Lactotransferrin (LTF) DMF5DLW MT DTT DMF5DLW MA Inhibitor DMF5DLW RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMF5DLW RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMF5DLW DI DMF5DLW DMF5DLW DN Alpha-D-Mannose DMF5DLW MI TTMF541 DMF5DLW MN Liver carboxylesterase (CES1) DMF5DLW MT DTT DMF5DLW MA Inhibitor DMF5DLW RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMF5DLW RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMF5DLW DI DMF5DLW DMF5DLW DN Alpha-D-Mannose DMF5DLW MI TTH0DUS DMF5DLW MN Low-density lipoprotein receptor (LDL-R) DMF5DLW MT DTT DMF5DLW MA Inhibitor DMF5DLW RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMF5DLW RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMF5DLW DI DMF5DLW DMF5DLW DN Alpha-D-Mannose DMF5DLW MI TTBXIM9 DMF5DLW MN Membrane-associated lectin type-C (CD209) DMF5DLW MT DTT DMF5DLW MA Inhibitor DMF5DLW RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMF5DLW RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMF5DLW DI DMF5DLW DMF5DLW DN Alpha-D-Mannose DMF5DLW MI TTZUFI5 DMF5DLW MN Nitric-oxide synthase brain (NOS1) DMF5DLW MT DTT DMF5DLW MA Inhibitor DMF5DLW RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMF5DLW RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMF5DLW DI DMF5DLW DMF5DLW DN Alpha-D-Mannose DMF5DLW MI TT9V5JH DMF5DLW MN Phospholipase A2 (PLA2G1B) DMF5DLW MT DTT DMF5DLW MA Inhibitor DMF5DLW RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMF5DLW RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMF5DLW DI DMF5DLW DMF5DLW DN Alpha-D-Mannose DMF5DLW MI TT8NGED DMF5DLW MN Prostaglandin G/H synthase 1 (COX-1) DMF5DLW MT DTT DMF5DLW MA Inhibitor DMF5DLW RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMF5DLW RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMF5DLW DI DMF5DLW DMF5DLW DN Alpha-D-Mannose DMF5DLW MI TTVRZUO DMF5DLW MN Reticulon-4 receptor (RTN4R) DMF5DLW MT DTT DMF5DLW MA Inhibitor DMF5DLW RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMF5DLW RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMF5DLW DI DMF5DLW DMF5DLW DN Alpha-D-Mannose DMF5DLW MI TTH0KSX DMF5DLW MN Rhodopsin (RHO) DMF5DLW MT DTT DMF5DLW MA Inhibitor DMF5DLW RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMF5DLW RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMF5DLW DI DMF5DLW DMF5DLW DN Alpha-D-Mannose DMF5DLW MI TTJDUNO DMF5DLW MN T-cell surface antigen CD2 (CD2) DMF5DLW MT DTT DMF5DLW MA Inhibitor DMF5DLW RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMF5DLW RU https://pubmed.ncbi.nlm.nih.gov/17139284 DM3NCM1 DI DM3NCM1 DM3NCM1 DN Alpha-D-Mannose-6-Phosphate DM3NCM1 MI TT95ICL DM3NCM1 MN Mannose-6-phosphate receptor (M6PR) DM3NCM1 MT DTT DM3NCM1 MA Inhibitor DM3NCM1 RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DM3NCM1 RU https://pubmed.ncbi.nlm.nih.gov/17139284 DM3NCM1 DI DM3NCM1 DM3NCM1 DN Alpha-D-Mannose-6-Phosphate DM3NCM1 MI TTLP3GX DM3NCM1 MN Pseudomonas Phosphomannomutase/phosphoglucomutase (Pseudo algC) DM3NCM1 MT DTT DM3NCM1 MA Inhibitor DM3NCM1 RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DM3NCM1 RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMULXO3 DI DMULXO3 DMULXO3 DN alpha-Emtbl DMULXO3 MI TTZ8EM9 DMULXO3 MN Glycine receptor (GlyR) DMULXO3 MT DTT DMULXO3 RN Subunit-specific action of an anticonvulsant thiobutyrolactone on recombinant glycine receptors involves a residue in the M2 membrane-spanning region. Mol Pharmacol. 2000 Jul;58(1):11-7. DMULXO3 RU https://pubmed.ncbi.nlm.nih.gov/10860922 DMMPOEK DI DMMPOEK DMMPOEK DN alpha-ergocryptine DMMPOEK MI TTJS8PY DMMPOEK MN 5-HT 6 receptor (HTR6) DMMPOEK MT DTT DMMPOEK MA Antagonist DMMPOEK RN Identification of residues in transmembrane regions III and VI that contribute to the ligand binding site of the serotonin 5-HT6 receptor. J Neurochem. 1998 Nov;71(5):2169-77. DMMPOEK RU https://pubmed.ncbi.nlm.nih.gov/9798944 DMYSCQU DI DMYSCQU DMYSCQU DN Alpha-eudesmol DMYSCQU MI TTX4QDJ DMYSCQU MN Voltage-gated calcium channel alpha Cav2.1 (CACNA1A) DMYSCQU MT DTT DMYSCQU MA Blocker DMYSCQU RN Alpha-eudesmol, a P/Q-type Ca(2+) channel blocker, inhibits neurogenic vasodilation and extravasation following electrical stimulation of trigeminal ganglion. Brain Res. 2000 Aug 4;873(1):94-101. DMYSCQU RU https://pubmed.ncbi.nlm.nih.gov/10915814 DM4GLZU DI DM4GLZU DM4GLZU DN alpha-fluoromethylenephosphonate DM4GLZU MI TTE2YJR DM4GLZU MN Lysophosphatidate-3 receptor (LPAR3) DM4GLZU MT DTT DM4GLZU MA Agonist DM4GLZU RN Structure-activity relationships of fluorinated lysophosphatidic acid analogues. J Med Chem. 2005 May 5;48(9):3319-27. DM4GLZU RU https://pubmed.ncbi.nlm.nih.gov/15857137 DMT17H0 DI DMT17H0 DMT17H0 DN Alpha-Homonojirimycin DMT17H0 MI TTLPC70 DMT17H0 MN Lysosomal alpha-glucosidase (GAA) DMT17H0 MT DTT DMT17H0 MA Inhibitor DMT17H0 RN In vitro inhibition of glycogen-degrading enzymes and glycosidases by six-membered sugar mimics and their evaluation in cell cultures. Bioorg Med Chem. 2008 Aug 1;16(15):7330-6. DMT17H0 RU https://pubmed.ncbi.nlm.nih.gov/18595718 DMIH38V DI DMIH38V DMIH38V DN ALPHA-HYDROXYFARNESYLPHOSPHONIC ACID DMIH38V MI TT7WZIJ DMIH38V MN CAAX farnesyltransferase beta (FNTB) DMIH38V MT DTT DMIH38V MA Inhibitor DMIH38V RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DMIH38V RU https://pubmed.ncbi.nlm.nih.gov/10592235 DMIH38V DI DMIH38V DMIH38V DN ALPHA-HYDROXYFARNESYLPHOSPHONIC ACID DMIH38V MI TTXQKM3 DMIH38V MN Farnesyl protein transferase (Ftase) DMIH38V MT DTT DMIH38V MA Inhibitor DMIH38V RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DMIH38V RU https://pubmed.ncbi.nlm.nih.gov/10592235 DMAQBKX DI DMAQBKX DMAQBKX DN Alpha-Hydroxy-Midazolam DMAQBKX MI TTXV4FI DMAQBKX MN Albendazole monooxygenase (CYP3A4) DMAQBKX MT DTT DMAQBKX MA Inhibitor DMAQBKX RN Design and synthesis of a new fluorescent probe for cytochrome P450 3A4 (CYP 3A4). Bioorg Med Chem Lett. 2003 Nov 3;13(21):3643-5. DMAQBKX RU https://pubmed.ncbi.nlm.nih.gov/14552748 DM5LFYN DI DM5LFYN DM5LFYN DN Alpha-ketoglutaric acid DM5LFYN MI DEY1CBW DM5LFYN MN Factor inhibiting HIF-1 (HIF1AN) DM5LFYN MT DME DM5LFYN MA Metabolism DM5LFYN RN The facial triad in the alpha-ketoglutarate dependent oxygenase FIH: a role for sterics in linking substrate binding to O2 activation. J Inorg Biochem. 2017 Jan;166:26-33. DM5LFYN RU https://www.ncbi.nlm.nih.gov/pubmed/?term=27815979 DM5LFYN DI DM5LFYN DM5LFYN DN Alpha-ketoglutaric acid DM5LFYN MI DEWO724 DM5LFYN MN HIF-prolyl hydroxylase 2 (EGLN1) DM5LFYN MT DME DM5LFYN MA Metabolism DM5LFYN RN Characterization of the human prolyl 4-hydroxylases that modify the hypoxia-inducible factor. J Biol Chem. 2003 Aug 15;278(33):30772-80. DM5LFYN RU https://www.ncbi.nlm.nih.gov/pubmed/?term=12788921 DM5LFYN DI DM5LFYN DM5LFYN DN Alpha-ketoglutaric acid DM5LFYN MI DEMQTKH DM5LFYN MN HIF-prolyl hydroxylase 3 (EGLN3) DM5LFYN MT DME DM5LFYN MA Metabolism DM5LFYN RN Characterization of the human prolyl 4-hydroxylases that modify the hypoxia-inducible factor. J Biol Chem. 2003 Aug 15;278(33):30772-80. DM5LFYN RU https://www.ncbi.nlm.nih.gov/pubmed/?term=12788921 DM5LFYN DI DM5LFYN DM5LFYN DN Alpha-ketoglutaric acid DM5LFYN MI DT2UQYR DM5LFYN MN Mitochondrial 2-oxodicarboxylate carrier (SLC25A21) DM5LFYN MT DTP DM5LFYN MA Substrate DM5LFYN RN Mitochondrial oxodicarboxylate carrier deficiency is associated with mitochondrial DNA depletion and spinal muscular atrophy-like disease. Genet Med. 2018 Oct;20(10):1224-1235. DM5LFYN RU http://www.ncbi.nlm.nih.gov/pubmed/29517768 DM5LFYN DI DM5LFYN DM5LFYN DN Alpha-ketoglutaric acid DM5LFYN MI DT0YAUQ DM5LFYN MN Mitochondrial 2-oxoglutarate/malate carrier (SLC25A11) DM5LFYN MT DTP DM5LFYN MA Substrate DM5LFYN RN The mitochondrial dicarboxylate and 2-oxoglutarate carriers do not transport glutathione. FEBS Lett. 2015 Feb 27;589(5):621-8. DM5LFYN RU http://www.ncbi.nlm.nih.gov/pubmed/25637873 DM5LFYN DI DM5LFYN DM5LFYN DN Alpha-ketoglutaric acid DM5LFYN MI TTAS1QK DM5LFYN MN Oxoglutarate receptor (OXGR1) DM5LFYN MT DTT DM5LFYN MA Agonist DM5LFYN RN Screening beta-arrestin recruitment for the identification of natural ligands for orphan G-protein-coupled receptors. J Biomol Screen. 2013 Jun;18(5):599-609. DM5LFYN RU https://pubmed.ncbi.nlm.nih.gov/23396314 DM5LFYN DI DM5LFYN DM5LFYN DN Alpha-ketoglutaric acid DM5LFYN MI DEW527E DM5LFYN MN Prolyl 3-hydroxylase 1 (P3H1) DM5LFYN MT DME DM5LFYN MA Metabolism DM5LFYN RN Characterization of recombinant human prolyl 3-hydroxylase isoenzyme 2, an enzyme modifying the basement membrane collagen IV. J Biol Chem. 2008 Jul 11;283(28):19432-9. DM5LFYN RU https://www.ncbi.nlm.nih.gov/pubmed/?term=18487197 DM5LFYN DI DM5LFYN DM5LFYN DN Alpha-ketoglutaric acid DM5LFYN MI DELB5PA DM5LFYN MN Prolyl 3-hydroxylase 2 (P3H2) DM5LFYN MT DME DM5LFYN MA Metabolism DM5LFYN RN Characterization of recombinant human prolyl 3-hydroxylase isoenzyme 2, an enzyme modifying the basement membrane collagen IV. J Biol Chem. 2008 Jul 11;283(28):19432-9. DM5LFYN RU https://www.ncbi.nlm.nih.gov/pubmed/?term=18487197 DM5LFYN DI DM5LFYN DM5LFYN DN Alpha-ketoglutaric acid DM5LFYN MI DESO5ZY DM5LFYN MN Prolyl 4-hydroxylase alpha-1 (P4HA1) DM5LFYN MT DME DM5LFYN MA Metabolism DM5LFYN RN Prolyl 4-hydroxylases, the key enzymes of collagen biosynthesis. Matrix Biol. 2003 Mar;22(1):15-24. DM5LFYN RU https://www.ncbi.nlm.nih.gov/pubmed/?term=12714038 DM5LFYN DI DM5LFYN DM5LFYN DN Alpha-ketoglutaric acid DM5LFYN MI DE5EGK0 DM5LFYN MN Prolyl 4-hydroxylase alpha-2 (P4HA2) DM5LFYN MT DME DM5LFYN MA Metabolism DM5LFYN RN Prolyl 4-hydroxylases, the key enzymes of collagen biosynthesis. Matrix Biol. 2003 Mar;22(1):15-24. DM5LFYN RU https://www.ncbi.nlm.nih.gov/pubmed/?term=12714038 DM5LFYN DI DM5LFYN DM5LFYN DN Alpha-ketoglutaric acid DM5LFYN MI DE2L4RX DM5LFYN MN Prolyl 4-hydroxylase alpha-3 (P4HA3) DM5LFYN MT DME DM5LFYN MA Metabolism DM5LFYN RN Identification and characterization of a third human, rat, and mouse collagen prolyl 4-hydroxylase isoenzyme. J Biol Chem. 2003 Nov 28;278(48):47685-93. DM5LFYN RU https://www.ncbi.nlm.nih.gov/pubmed/?term=14500733 DM5LFYN DI DM5LFYN DM5LFYN DN Alpha-ketoglutaric acid DM5LFYN MI DTKXTPW DM5LFYN MN Sodium/dicarboxylate cotransporter 3 (SLC13A3) DM5LFYN MT DTP DM5LFYN MA Substrate DM5LFYN RN SLC13A3 variants cause acute reversible leukoencephalopathy and -ketoglutarate accumulation. Ann Neurol. 2019 Mar;85(3):385-395. DM5LFYN RU http://www.ncbi.nlm.nih.gov/pubmed/30635937 DM5LFYN DI DM5LFYN DM5LFYN DN Alpha-ketoglutaric acid DM5LFYN MI DTFPWJ9 DM5LFYN MN Sodium-coupled citrate transporter (SLC13A5) DM5LFYN MT DTP DM5LFYN MA Substrate DM5LFYN RN SLC13 family of Na+ coupled di- and tri-carboxylate/sulfate transporters. Mol Aspects Med. 2013 Apr-Jun;34(2-3):299-312. DM5LFYN RU http://www.ncbi.nlm.nih.gov/pubmed/23506872 DMBZTS5 DI DMBZTS5 DMBZTS5 DN Alpha-ketoisovalerate DMBZTS5 MI TTF9OQ6 DMBZTS5 MN Branched-chain-amino-acid transaminase 2 (BCAT2) DMBZTS5 MT DTT DMBZTS5 MA Inhibitor DMBZTS5 RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMBZTS5 RU https://pubmed.ncbi.nlm.nih.gov/17139284 DM2I564 DI DM2I564 DM2I564 DN Alpha-l-arabinose DM2I564 MI DEBI60T DM2I564 MN L-arabinose isomerase (araA) DM2I564 MT DME DM2I564 MA Metabolism DM2I564 RN Protein purification, crystallization and preliminary X-ray diffraction analysis of L-arabinose isomerase from Lactobacillus fermentum CGMCC2921. Acta Crystallogr F Struct Biol Commun. 2015 Jan 1;71(Pt 1):28-33. DM2I564 RU https://pubmed.ncbi.nlm.nih.gov/25615964 DMY64HE DI DMY64HE DMY64HE DN Alpha-linolenic acid DMY64HE MI DE30GZN DMY64HE MN Carboxylic ester hydrolase (CEH) DMY64HE MT DME DMY64HE MA Metabolism DMY64HE RN Immunogenic inhibition of prominent ruminal bacteria as a means to reduce lipolysis and biohydrogenation activity in vitro. Food Chem. 2017 Mar 1;218:372-377. DMY64HE RU https://pubmed.ncbi.nlm.nih.gov/27719923 DMY64HE DI DMY64HE DMY64HE DN Alpha-linolenic acid DMY64HE MI TTB8FUC DMY64HE MN Free fatty acid receptor 1 (GPR40) DMY64HE MT DTT DMY64HE MA Agonist DMY64HE RN Free fatty acids regulate insulin secretion from pancreatic beta cells through GPR40. Nature. 2003 Mar 13;422(6928):173-6. DMY64HE RU https://pubmed.ncbi.nlm.nih.gov/12629551 DMY64HE DI DMY64HE DMY64HE DN Alpha-linolenic acid DMY64HE MI TT08JVB DMY64HE MN G-protein coupled receptor 120 (GPR120) DMY64HE MT DTT DMY64HE MA Agonist DMY64HE RN Cloning and characterization of the rat free fatty acid receptor GPR120: in vivo effect of the natural ligand on GLP-1 secretion and proliferation of pancreatic beta cells. Naunyn Schmiedebergs Arch Pharmacol. 2008 Jun;377(4-6):515-22. DMY64HE RU https://pubmed.ncbi.nlm.nih.gov/18320172 DMY64HE DI DMY64HE DMY64HE DN Alpha-linolenic acid DMY64HE MI DE073H6 DMY64HE MN Prostaglandin G/H synthase 1 (COX-1) DMY64HE MT DME DMY64HE MA Metabolism DMY64HE RN Divergent cyclooxygenase responses to fatty acid structure and peroxide level in fish and mammalian prostaglandin H synthases. FASEB J. 2006 Jun;20(8):1097-108. DMY64HE RU https://www.ncbi.nlm.nih.gov/pubmed/?term=16770009 DMY64HE DI DMY64HE DMY64HE DN Alpha-linolenic acid DMY64HE MI TTVKILB DMY64HE MN Prostaglandin G/H synthase 2 (COX-2) DMY64HE MT DTT DMY64HE MA Inhibitor DMY64HE RN Cox-2 inhibitory effects of naturally occurring and modified fatty acids. J Nat Prod. 2001 Jun;64(6):745-9. DMY64HE RU https://pubmed.ncbi.nlm.nih.gov/11421736 DMY64HE DI DMY64HE DMY64HE DN Alpha-linolenic acid DMY64HE MI DE492CE DMY64HE MN Prostaglandin G/H synthase 2 (COX-2) DMY64HE MT DME DMY64HE MA Metabolism DMY64HE RN Divergent cyclooxygenase responses to fatty acid structure and peroxide level in fish and mammalian prostaglandin H synthases. FASEB J. 2006 Jun;20(8):1097-108. DMY64HE RU https://www.ncbi.nlm.nih.gov/pubmed/?term=16770009 DMCAYXF DI DMCAYXF DMCAYXF DN alpha-methyl-5-HT DMCAYXF MI TT6MSOK DMCAYXF MN 5-HT 1D receptor (HTR1D) DMCAYXF MT DTT DMCAYXF MA Agonist DMCAYXF RN Alniditan, a new 5-hydroxytryptamine1D agonist and migraine-abortive agent: ligand-binding properties of human 5-hydroxytryptamine1D alpha, human 5-hydroxytryptamine1D beta, and calf 5-hydroxytryptamine1D receptors investigated with [3H]5-hydroxytryptamine and [3H]alniditan. Mol Pharmacol. 1996 Dec;50(6):1567-80. DMCAYXF RU https://pubmed.ncbi.nlm.nih.gov/8967979 DMCAYXF DI DMCAYXF DMCAYXF DN alpha-methyl-5-HT DMCAYXF MI TTCPG9S DMCAYXF MN 5-HT 1E receptor (HTR1E) DMCAYXF MT DTT DMCAYXF MA Agonist DMCAYXF RN Molecular cloning and pharmacological characterization of the guinea pig 5-HT1E receptor. Eur J Pharmacol. 2004 Jan 26;484(2-3):127-39. DMCAYXF RU https://pubmed.ncbi.nlm.nih.gov/14744596 DMCAYXF DI DMCAYXF DMCAYXF DN alpha-methyl-5-HT DMCAYXF MI TT0MI3F DMCAYXF MN 5-HT 1F receptor (HTR1F) DMCAYXF MT DTT DMCAYXF MA Agonist DMCAYXF RN Cloning of another human serotonin receptor (5-HT1F): a fifth 5-HT1 receptor subtype coupled to the inhibition of adenylate cyclase. Proc Natl Acad Sci U S A. 1993 Jan 15;90(2):408-12. DMCAYXF RU https://pubmed.ncbi.nlm.nih.gov/8380639 DMCAYXF DI DMCAYXF DMCAYXF DN alpha-methyl-5-HT DMCAYXF MI TTJQOD7 DMCAYXF MN 5-HT 2A receptor (HTR2A) DMCAYXF MT DTT DMCAYXF MA Agonist DMCAYXF RN Differential modes of agonist binding to 5-hydroxytryptamine(2A) serotonin receptors revealed by mutation and molecular modeling of conserved residues in transmembrane region 5. Mol Pharmacol. 2000 Nov;58(5):877-86. DMCAYXF RU https://pubmed.ncbi.nlm.nih.gov/11040033 DMCAYXF DI DMCAYXF DMCAYXF DN alpha-methyl-5-HT DMCAYXF MI TT0K1SC DMCAYXF MN 5-HT 2B receptor (HTR2B) DMCAYXF MT DTT DMCAYXF MA Agonist DMCAYXF RN The 5-HT4 receptor agonist, tegaserod, is a potent 5-HT2B receptor antagonist in vitro and in vivo. Br J Pharmacol. 2004 Nov;143(5):549-60. DMCAYXF RU https://pubmed.ncbi.nlm.nih.gov/15466450 DMCAYXF DI DMCAYXF DMCAYXF DN alpha-methyl-5-HT DMCAYXF MI TTWJBZ5 DMCAYXF MN 5-HT 2C receptor (HTR2C) DMCAYXF MT DTT DMCAYXF MA Agonist DMCAYXF RN High-affinity agonist binding correlates with efficacy (intrinsic activity) at the human serotonin 5-HT2A and 5-HT2C receptors: evidence favoring the ternary complex and two-state models of agonist action. J Neurochem. 1999 May;72(5):2127-34. DMCAYXF RU https://pubmed.ncbi.nlm.nih.gov/10217294 DMCAYXF DI DMCAYXF DMCAYXF DN alpha-methyl-5-HT DMCAYXF MI TT07C3Y DMCAYXF MN 5-HT 4 receptor (HTR4) DMCAYXF MT DTT DMCAYXF MA Agonist DMCAYXF RN [3H]RS 57639, a high affinity, selective 5-HT4 receptor partial agonist, specifically labels guinea-pig striatal and rat cloned (5-HT4S and 5-HT4L) receptors. Neuropharmacology. 1997 Apr-May;36(4-5):671-9. DMCAYXF RU https://pubmed.ncbi.nlm.nih.gov/9225293 DMCAYXF DI DMCAYXF DMCAYXF DN alpha-methyl-5-HT DMCAYXF MI TTJS8PY DMCAYXF MN 5-HT 6 receptor (HTR6) DMCAYXF MT DTT DMCAYXF MA Agonist DMCAYXF RN Identification of residues in transmembrane regions III and VI that contribute to the ligand binding site of the serotonin 5-HT6 receptor. J Neurochem. 1998 Nov;71(5):2169-77. DMCAYXF RU https://pubmed.ncbi.nlm.nih.gov/9798944 DM7DBTZ DI DM7DBTZ DM7DBTZ DN Alpha-methylalanyl-L-proline butylamide DM7DBTZ MI TTQ7R2V DM7DBTZ MN Tripeptidyl-peptidase II (TPP2) DM7DBTZ MT DTT DM7DBTZ MA Inhibitor DM7DBTZ RN Inhibitors of tripeptidyl peptidase II. 3. Derivation of butabindide by successive structure optimizations leading to a potential general approach ... J Med Chem. 2005 Nov 17;48(23):7333-42. DM7DBTZ RU https://pubmed.ncbi.nlm.nih.gov/16279793 DM892JF DI DM892JF DM892JF DN Alpha-methyl-alpha-phenylsuccinimide (MPS) DM892JF MI TT729IR DM892JF MN Voltage-gated calcium channel alpha Cav3.1 (CACNA1G) DM892JF MT DTT DM892JF MA Blocker DM892JF RN Block of cloned human T-type calcium channels by succinimide antiepileptic drugs. Mol Pharmacol. 2001 Nov;60(5):1121-32. DM892JF RU https://pubmed.ncbi.nlm.nih.gov/11641441 DM0C4GP DI DM0C4GP DM0C4GP DN Alpha-methylcubebin DM0C4GP MI TTXV4FI DM0C4GP MN Albendazole monooxygenase (CYP3A4) DM0C4GP MT DTT DM0C4GP MA Inhibitor DM0C4GP RN Potent CYP3A4 inhibitory constituents of Piper cubeba. J Nat Prod. 2005 Jan;68(1):64-8. DM0C4GP RU https://pubmed.ncbi.nlm.nih.gov/15679319 DM3YGWL DI DM3YGWL DM3YGWL DN Alpha-Methylisocitric Acid DM3YGWL MI TTMTF2P DM3YGWL MN Citrate hydro-lyase (ACO2) DM3YGWL MT DTT DM3YGWL MA Inhibitor DM3YGWL RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DM3YGWL RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMAUH96 DI DMAUH96 DMAUH96 DN alpha-methylphenylalanine DMAUH96 MI TTGSVH2 DMAUH96 MN Phenylalanine hydroxylase (PAH) DMAUH96 MT DTT DMAUH96 MA Inhibitor DMAUH96 RN Alpha-methylphenylalanine, a new inducer of chronic hyperphenylalaninemia in sucling rats. Science. 1976 Jun 4;192(4243):1007-8. DMAUH96 RU https://pubmed.ncbi.nlm.nih.gov/944951 DMCIH1X DI DMCIH1X DMCIH1X DN alpha-methylserine-O-phosphate DMCIH1X MI TTXJ47W DMCIH1X MN Metabotropic glutamate receptor 2 (mGluR2) DMCIH1X MT DTT DMCIH1X MA Antagonist DMCIH1X RN Characterization of [3H]-(2S,2'R,3'R)-2-(2',3'-dicarboxy-cyclopropyl)glycine ([3H]-DCG IV) binding to metabotropic mGlu2 receptor-transfected cell membranes. Br J Pharmacol. 1998 Feb;123(3):497-504. DMCIH1X RU https://pubmed.ncbi.nlm.nih.gov/9504391 DMCIH1X DI DMCIH1X DMCIH1X DN alpha-methylserine-O-phosphate DMCIH1X MI TTWRP2F DMCIH1X MN Metabotropic glutamate receptor 6 (mGluR6) DMCIH1X MT DTT DMCIH1X MA Antagonist DMCIH1X RN The metabotropic glutamate receptors: structure, activation mechanism and pharmacology. Curr Drug Targets CNS Neurol Disord. 2002 Jun;1(3):297-317. DMCIH1X RU https://pubmed.ncbi.nlm.nih.gov/12769621 DMCIH1X DI DMCIH1X DMCIH1X DN alpha-methylserine-O-phosphate DMCIH1X MI TT0I76D DMCIH1X MN Metabotropic glutamate receptor 7 (mGluR7) DMCIH1X MT DTT DMCIH1X MA Antagonist DMCIH1X RN Binding of [3H](2S,1'S,2'S)-2-(9-xanthylmethyl)-2-(2'-carboxycyclopropyl) glycine ([3H]LY341495) to cell membranes expressing recombinant human group III metabotropic glutamate receptor subtypes. Naunyn Schmiedebergs Arch Pharmacol. 2000 Dec;362(6):546-54. DMCIH1X RU https://pubmed.ncbi.nlm.nih.gov/11138847 DMCIH1X DI DMCIH1X DMCIH1X DN alpha-methylserine-O-phosphate DMCIH1X MI TT0IFKL DMCIH1X MN Metabotropic glutamate receptor 8 (mGluR8) DMCIH1X MT DTT DMCIH1X MA Antagonist DMCIH1X RN The metabotropic glutamate receptors: structure, activation mechanism and pharmacology. Curr Drug Targets CNS Neurol Disord. 2002 Jun;1(3):297-317. DMCIH1X RU https://pubmed.ncbi.nlm.nih.gov/12769621 DML7SU3 DI DML7SU3 DML7SU3 DN Alpha-monofluoromethyl-3,4-dehydroornithine DML7SU3 MI TTUMGNO DML7SU3 MN Ornithine decarboxylase (ODC1) DML7SU3 MT DTT DML7SU3 MA Inhibitor DML7SU3 RN Plasmodium falciparum and Plasmodium berghei: effects of ornithine decarboxylase inhibitors on erythrocytic schizogony. Exp Parasitol. 1987 Oct;64(2):237-43. DML7SU3 RU https://pubmed.ncbi.nlm.nih.gov/3115816 DMJTGZV DI DMJTGZV DMJTGZV DN Alpha-monofluoromethyl-3,4-dehydroornithine ethyl ester DMJTGZV MI TTUMGNO DMJTGZV MN Ornithine decarboxylase (ODC1) DMJTGZV MT DTT DMJTGZV MA Inhibitor DMJTGZV RN Plasmodium falciparum and Plasmodium berghei: effects of ornithine decarboxylase inhibitors on erythrocytic schizogony. Exp Parasitol. 1987 Oct;64(2):237-43. DMJTGZV RU https://pubmed.ncbi.nlm.nih.gov/3115816 DMGI9SM DI DMGI9SM DMGI9SM DN Alpha-monofluoromethyl-3,4-dehydroornithine methyl ester DMGI9SM MI TTUMGNO DMGI9SM MN Ornithine decarboxylase (ODC1) DMGI9SM MT DTT DMGI9SM MA Inhibitor DMGI9SM RN Plasmodium falciparum and Plasmodium berghei: effects of ornithine decarboxylase inhibitors on erythrocytic schizogony. Exp Parasitol. 1987 Oct;64(2):237-43. DMGI9SM RU https://pubmed.ncbi.nlm.nih.gov/3115816 DMELOIQ DI DMELOIQ DMELOIQ DN Alpha-naphthoflavone DMELOIQ MI TTSZLWK DMELOIQ MN Aromatase (CYP19A1) DMELOIQ MT DTT DMELOIQ MA Inhibitor DMELOIQ RN Pharmacophore modeling strategies for the development of novel nonsteroidal inhibitors of human aromatase (CYP19). Bioorg Med Chem Lett. 2010 May 15;20(10):3050-64. DMELOIQ RU https://pubmed.ncbi.nlm.nih.gov/20413308 DMELOIQ DI DMELOIQ DMELOIQ DN Alpha-naphthoflavone DMELOIQ MI TTK3PY9 DMELOIQ MN DNA-dependent protein kinase catalytic (PRKDC) DMELOIQ MT DTT DMELOIQ MA Inhibitor DMELOIQ RN Selective benzopyranone and pyrimido[2,1-a]isoquinolin-4-one inhibitors of DNA-dependent protein kinase: synthesis, structure-activity studies, and... J Med Chem. 2005 Jan 27;48(2):569-85. DMELOIQ RU https://pubmed.ncbi.nlm.nih.gov/15658870 DM0KXN4 DI DM0KXN4 DM0KXN4 DN Alpha-oxoadipic acid DM0KXN4 MI DT2UQYR DM0KXN4 MN Mitochondrial 2-oxodicarboxylate carrier (SLC25A21) DM0KXN4 MT DTP DM0KXN4 MA Substrate DM0KXN4 RN Mitochondrial oxodicarboxylate carrier deficiency is associated with mitochondrial DNA depletion and spinal muscular atrophy-like disease. Genet Med. 2018 Oct;20(10):1224-1235. DM0KXN4 RU http://www.ncbi.nlm.nih.gov/pubmed/29517768 DMT6KI7 DI DMT6KI7 DMT6KI7 DN Alpha-Phosphoribosylpyrophosphoric Acid DMT6KI7 MI TTAFJUD DMT6KI7 MN Orotidine 5'-monophosphate decarboxylase (UMPS) DMT6KI7 MT DTT DMT6KI7 MA Inhibitor DMT6KI7 RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DMT6KI7 RU https://pubmed.ncbi.nlm.nih.gov/10592235 DMT6KI7 DI DMT6KI7 DMT6KI7 DN Alpha-Phosphoribosylpyrophosphoric Acid DMT6KI7 MI TTBL49X DMT6KI7 MN Plasmodium Hypoxanthine-guanine phosphoribosyltransferase (Malaria LACZ) DMT6KI7 MT DTT DMT6KI7 MA Inhibitor DMT6KI7 RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DMT6KI7 RU https://pubmed.ncbi.nlm.nih.gov/10592235 DMQKMX3 DI DMQKMX3 DMQKMX3 DN alpha-propyldopacetamide DMQKMX3 MI TT3KLDP DMQKMX3 MN L-Tryptophan hydroxylase 2 (TPH2) DMQKMX3 MT DTT DMQKMX3 MA Inhibitor DMQKMX3 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1242). DMQKMX3 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1242 DMQKMX3 DI DMQKMX3 DMQKMX3 DN alpha-propyldopacetamide DMQKMX3 MI TTZSJHV DMQKMX3 MN Tryptophan 5-hydroxylase 1 (TPH1) DMQKMX3 MT DTT DMQKMX3 MA Inhibitor DMQKMX3 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1241). DMQKMX3 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1241 DMQKMX3 DI DMQKMX3 DMQKMX3 DN alpha-propyldopacetamide DMQKMX3 MI TTUHP71 DMQKMX3 MN Tyrosine 3-monooxygenase (TH) DMQKMX3 MT DTT DMQKMX3 MA Inhibitor DMQKMX3 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1243). DMQKMX3 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1243 DMWL172 DI DMWL172 DMWL172 DN Alpha-Sulfanyl(2,4-dichlorobenzyl)phosphonic acid DMWL172 MI TTHI19T DMWL172 MN Staphylococcus Beta-lactamase (Stap-coc blaZ) DMWL172 MT DTT DMWL172 MA Inhibitor DMWL172 RN Mercaptophosphonate compounds as broad-spectrum inhibitors of the metallo-beta-lactamases. J Med Chem. 2010 Jul 8;53(13):4862-76. DMWL172 RU https://pubmed.ncbi.nlm.nih.gov/20527888 DM42M6I DI DM42M6I DM42M6I DN Alpha-Sulfanyl(2-methoxybenzyl)phosphonic acid DM42M6I MI TTHI19T DM42M6I MN Staphylococcus Beta-lactamase (Stap-coc blaZ) DM42M6I MT DTT DM42M6I MA Inhibitor DM42M6I RN Mercaptophosphonate compounds as broad-spectrum inhibitors of the metallo-beta-lactamases. J Med Chem. 2010 Jul 8;53(13):4862-76. DM42M6I RU https://pubmed.ncbi.nlm.nih.gov/20527888 DMRIWDV DI DMRIWDV DMRIWDV DN Alpha-Sulfanyl(4-bromobenzyl)phosphonic acid DMRIWDV MI TTHI19T DMRIWDV MN Staphylococcus Beta-lactamase (Stap-coc blaZ) DMRIWDV MT DTT DMRIWDV MA Inhibitor DMRIWDV RN Mercaptophosphonate compounds as broad-spectrum inhibitors of the metallo-beta-lactamases. J Med Chem. 2010 Jul 8;53(13):4862-76. DMRIWDV RU https://pubmed.ncbi.nlm.nih.gov/20527888 DMP6GXU DI DMP6GXU DMP6GXU DN Alpha-Sulfanyl(4-chlorobenzyl)phosphonic acid DMP6GXU MI TTHI19T DMP6GXU MN Staphylococcus Beta-lactamase (Stap-coc blaZ) DMP6GXU MT DTT DMP6GXU MA Inhibitor DMP6GXU RN Mercaptophosphonate compounds as broad-spectrum inhibitors of the metallo-beta-lactamases. J Med Chem. 2010 Jul 8;53(13):4862-76. DMP6GXU RU https://pubmed.ncbi.nlm.nih.gov/20527888 DMP9V42 DI DMP9V42 DMP9V42 DN Alpha-Sulfanyl(4-fluorobenzyl)phosphonic acid DMP9V42 MI TTHI19T DMP9V42 MN Staphylococcus Beta-lactamase (Stap-coc blaZ) DMP9V42 MT DTT DMP9V42 MA Inhibitor DMP9V42 RN Mercaptophosphonate compounds as broad-spectrum inhibitors of the metallo-beta-lactamases. J Med Chem. 2010 Jul 8;53(13):4862-76. DMP9V42 RU https://pubmed.ncbi.nlm.nih.gov/20527888 DMWB07I DI DMWB07I DMWB07I DN Alpha-Sulfanylbenzylphosphonic acid DMWB07I MI TTHI19T DMWB07I MN Staphylococcus Beta-lactamase (Stap-coc blaZ) DMWB07I MT DTT DMWB07I MA Inhibitor DMWB07I RN Mercaptophosphonate compounds as broad-spectrum inhibitors of the metallo-beta-lactamases. J Med Chem. 2010 Jul 8;53(13):4862-76. DMWB07I RU https://pubmed.ncbi.nlm.nih.gov/20527888 DM19NAI DI DM19NAI DM19NAI DN Alpha-Sulfanylpropylphosphonic acid DM19NAI MI TTHI19T DM19NAI MN Staphylococcus Beta-lactamase (Stap-coc blaZ) DM19NAI MT DTT DM19NAI MA Inhibitor DM19NAI RN Mercaptophosphonate compounds as broad-spectrum inhibitors of the metallo-beta-lactamases. J Med Chem. 2010 Jul 8;53(13):4862-76. DM19NAI RU https://pubmed.ncbi.nlm.nih.gov/20527888 DMDI2KH DI DMDI2KH DMDI2KH DN alsterpaullone 2-cyanoethyl DMDI2KH MI TTH6V3D DMDI2KH MN Cyclin-dependent kinase 1 (CDK1) DMDI2KH MT DTT DMDI2KH MA Inhibitor DMDI2KH RN A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases. Proc Natl Acad Sci U S A. 2007 Dec 18;104(51):20523-8. DMDI2KH RU https://pubmed.ncbi.nlm.nih.gov/18077363 DMDI2KH DI DMDI2KH DMDI2KH DN alsterpaullone 2-cyanoethyl DMDI2KH MI TTRSMW9 DMDI2KH MN Glycogen synthase kinase-3 beta (GSK-3B) DMDI2KH MT DTT DMDI2KH MA Inhibitor DMDI2KH RN A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases. Proc Natl Acad Sci U S A. 2007 Dec 18;104(51):20523-8. DMDI2KH RU https://pubmed.ncbi.nlm.nih.gov/18077363 DM2FLDJ DI DM2FLDJ DM2FLDJ DN Alstiphyllanine D DM2FLDJ MI TTF8JAT DM2FLDJ MN SLC5A2 messenger RNA (SLC5A2 mRNA) DM2FLDJ MT DTT DM2FLDJ MA Inhibitor DM2FLDJ RN Alstiphyllanines E-H, picraline and ajmaline-type alkaloids from Alstonia macrophylla inhibiting sodium glucose cotransporter. Bioorg Med Chem. 2010 Mar 15;18(6):2152-2158. DM2FLDJ RU https://pubmed.ncbi.nlm.nih.gov/20189404 DM2FLDJ DI DM2FLDJ DM2FLDJ DN Alstiphyllanine D DM2FLDJ MI TT2UE56 DM2FLDJ MN Sodium/glucose cotransporter 1 (SGLT1) DM2FLDJ MT DTT DM2FLDJ MA Inhibitor DM2FLDJ RN Alstiphyllanines E-H, picraline and ajmaline-type alkaloids from Alstonia macrophylla inhibiting sodium glucose cotransporter. Bioorg Med Chem. 2010 Mar 15;18(6):2152-2158. DM2FLDJ RU https://pubmed.ncbi.nlm.nih.gov/20189404 DMTNQ5E DI DMTNQ5E DMTNQ5E DN Alstiphyllanine E DMTNQ5E MI TTF8JAT DMTNQ5E MN SLC5A2 messenger RNA (SLC5A2 mRNA) DMTNQ5E MT DTT DMTNQ5E MA Inhibitor DMTNQ5E RN Alstiphyllanines E-H, picraline and ajmaline-type alkaloids from Alstonia macrophylla inhibiting sodium glucose cotransporter. Bioorg Med Chem. 2010 Mar 15;18(6):2152-2158. DMTNQ5E RU https://pubmed.ncbi.nlm.nih.gov/20189404 DMTNQ5E DI DMTNQ5E DMTNQ5E DN Alstiphyllanine E DMTNQ5E MI TT2UE56 DMTNQ5E MN Sodium/glucose cotransporter 1 (SGLT1) DMTNQ5E MT DTT DMTNQ5E MA Inhibitor DMTNQ5E RN Alstiphyllanines E-H, picraline and ajmaline-type alkaloids from Alstonia macrophylla inhibiting sodium glucose cotransporter. Bioorg Med Chem. 2010 Mar 15;18(6):2152-2158. DMTNQ5E RU https://pubmed.ncbi.nlm.nih.gov/20189404 DMKRAEW DI DMKRAEW DMKRAEW DN Alstiphyllanine F DMKRAEW MI TTF8JAT DMKRAEW MN SLC5A2 messenger RNA (SLC5A2 mRNA) DMKRAEW MT DTT DMKRAEW MA Inhibitor DMKRAEW RN Alstiphyllanines E-H, picraline and ajmaline-type alkaloids from Alstonia macrophylla inhibiting sodium glucose cotransporter. Bioorg Med Chem. 2010 Mar 15;18(6):2152-2158. DMKRAEW RU https://pubmed.ncbi.nlm.nih.gov/20189404 DMKRAEW DI DMKRAEW DMKRAEW DN Alstiphyllanine F DMKRAEW MI TT2UE56 DMKRAEW MN Sodium/glucose cotransporter 1 (SGLT1) DMKRAEW MT DTT DMKRAEW MA Inhibitor DMKRAEW RN Alstiphyllanines E-H, picraline and ajmaline-type alkaloids from Alstonia macrophylla inhibiting sodium glucose cotransporter. Bioorg Med Chem. 2010 Mar 15;18(6):2152-2158. DMKRAEW RU https://pubmed.ncbi.nlm.nih.gov/20189404 DMBGAWI DI DMBGAWI DMBGAWI DN ALTANSERIN DMBGAWI MI TTJQOD7 DMBGAWI MN 5-HT 2A receptor (HTR2A) DMBGAWI MT DTT DMBGAWI MA Inhibitor DMBGAWI RN Synthesis and in vitro affinities of various MDL 100907 derivatives as potential 18F-radioligands for 5-HT2A receptor imaging with PET. Bioorg Med Chem. 2009 Apr 15;17(8):2989-3002. DMBGAWI RU https://pubmed.ncbi.nlm.nih.gov/19329329 DMYCS0B DI DMYCS0B DMYCS0B DN ALTENUSIN DMYCS0B MI TTL53M6 DMYCS0B MN Induced myeloid leukemia cell differentiation protein Mcl-1 (MCL1) DMYCS0B MT DTT DMYCS0B MA Inhibitor DMYCS0B RN In silico identification and biochemical evaluation of novel inhibitors of NRH:quinone oxidoreductase 2 (NQO2). Bioorg Med Chem Lett. 2010 Dec 15;20(24):7331-6. DMYCS0B RU https://pubmed.ncbi.nlm.nih.gov/21074425 DMDLN9S DI DMDLN9S DMDLN9S DN ALTU-236 DMDLN9S MI TTGSVH2 DMDLN9S MN Phenylalanine hydroxylase (PAH) DMDLN9S MT DTT DMDLN9S MA Modulator DMDLN9S RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1240). DMDLN9S RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1240 DMP26K9 DI DMP26K9 DMP26K9 DN Alx 1393 DMP26K9 MI TTI0138 DMP26K9 MN Glycine transporter-2 (SLC6A5) DMP26K9 MT DTT DMP26K9 MA Inhibitor DMP26K9 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 936). DMP26K9 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=936 DMFVGXW DI DMFVGXW DMFVGXW DN AM-1241 DMFVGXW MI TT6OEDT DMFVGXW MN Cannabinoid receptor 1 (CB1) DMFVGXW MT DTT DMFVGXW MA Inhibitor DMFVGXW RN Indol-3-ylcycloalkyl ketones: effects of N1 substituted indole side chain variations on CB(2) cannabinoid receptor activity. J Med Chem. 2010 Jan 14;53(1):295-315. DMFVGXW RU https://pubmed.ncbi.nlm.nih.gov/19921781 DMFVGXW DI DMFVGXW DMFVGXW DN AM-1241 DMFVGXW MI TTMSFAW DMFVGXW MN Cannabinoid receptor 2 (CB2) DMFVGXW MT DTT DMFVGXW MA Inhibitor DMFVGXW RN Indol-3-ylcycloalkyl ketones: effects of N1 substituted indole side chain variations on CB(2) cannabinoid receptor activity. J Med Chem. 2010 Jan 14;53(1):295-315. DMFVGXW RU https://pubmed.ncbi.nlm.nih.gov/19921781 DMGCOQF DI DMGCOQF DMGCOQF DN AM-156 DMGCOQF MI TTQDMX5 DMGCOQF MN Prostaglandin D2 receptor 2 (PTGDR2) DMGCOQF MT DTT DMGCOQF MA Antagonist DMGCOQF RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 339). DMGCOQF RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=339 DMO7QUP DI DMO7QUP DMO7QUP DN AM-1710 DMO7QUP MI TT6OEDT DMO7QUP MN Cannabinoid receptor 1 (CB1) DMO7QUP MT DTT DMO7QUP MA Inhibitor DMO7QUP RN Cannabilactones: a novel class of CB2 selective agonists with peripheral analgesic activity. J Med Chem. 2007 Dec 27;50(26):6493-500. DMO7QUP RU https://pubmed.ncbi.nlm.nih.gov/18038967 DMO7QUP DI DMO7QUP DMO7QUP DN AM-1710 DMO7QUP MI TTMSFAW DMO7QUP MN Cannabinoid receptor 2 (CB2) DMO7QUP MT DTT DMO7QUP MA Inhibitor DMO7QUP RN Cannabilactones: a novel class of CB2 selective agonists with peripheral analgesic activity. J Med Chem. 2007 Dec 27;50(26):6493-500. DMO7QUP RU https://pubmed.ncbi.nlm.nih.gov/18038967 DMW9ERM DI DMW9ERM DMW9ERM DN AM-1714 DMW9ERM MI TT6OEDT DMW9ERM MN Cannabinoid receptor 1 (CB1) DMW9ERM MT DTT DMW9ERM MA Inhibitor DMW9ERM RN Cannabilactones: a novel class of CB2 selective agonists with peripheral analgesic activity. J Med Chem. 2007 Dec 27;50(26):6493-500. DMW9ERM RU https://pubmed.ncbi.nlm.nih.gov/18038967 DMW9ERM DI DMW9ERM DMW9ERM DN AM-1714 DMW9ERM MI TTMSFAW DMW9ERM MN Cannabinoid receptor 2 (CB2) DMW9ERM MT DTT DMW9ERM MA Inhibitor DMW9ERM RN Cannabilactones: a novel class of CB2 selective agonists with peripheral analgesic activity. J Med Chem. 2007 Dec 27;50(26):6493-500. DMW9ERM RU https://pubmed.ncbi.nlm.nih.gov/18038967 DMKJQZ4 DI DMKJQZ4 DMKJQZ4 DN AM-1715 DMKJQZ4 MI TT6OEDT DMKJQZ4 MN Cannabinoid receptor 1 (CB1) DMKJQZ4 MT DTT DMKJQZ4 MA Inhibitor DMKJQZ4 RN Cannabilactones: a novel class of CB2 selective agonists with peripheral analgesic activity. J Med Chem. 2007 Dec 27;50(26):6493-500. DMKJQZ4 RU https://pubmed.ncbi.nlm.nih.gov/18038967 DMKJQZ4 DI DMKJQZ4 DMKJQZ4 DN AM-1715 DMKJQZ4 MI TTMSFAW DMKJQZ4 MN Cannabinoid receptor 2 (CB2) DMKJQZ4 MT DTT DMKJQZ4 MA Inhibitor DMKJQZ4 RN Cannabilactones: a novel class of CB2 selective agonists with peripheral analgesic activity. J Med Chem. 2007 Dec 27;50(26):6493-500. DMKJQZ4 RU https://pubmed.ncbi.nlm.nih.gov/18038967 DMTAWHL DI DMTAWHL DMTAWHL DN AM251 DMTAWHL MI TT6OEDT DMTAWHL MN Cannabinoid receptor 1 (CB1) DMTAWHL MT DTT DMTAWHL MA Antagonist DMTAWHL RN Anandamide is able to inhibit trigeminal neurons using an in vivo model of trigeminovascular-mediated nociception. J Pharmacol Exp Ther. 2004 Apr;309(1):56-63. DMTAWHL RU https://pubmed.ncbi.nlm.nih.gov/14718591 DMOKN27 DI DMOKN27 DMOKN27 DN AM-281 DMOKN27 MI TT6OEDT DMOKN27 MN Cannabinoid receptor 1 (CB1) DMOKN27 MT DTT DMOKN27 MA Inhibitor DMOKN27 RN Synthesis and pharmacological evaluation of coumarin derivatives as cannabinoid receptor antagonists and inverse agonists. Bioorg Med Chem. 2009 Apr 1;17(7):2842-51. DMOKN27 RU https://pubmed.ncbi.nlm.nih.gov/19278853 DMOKN27 DI DMOKN27 DMOKN27 DN AM-281 DMOKN27 MI TTMSFAW DMOKN27 MN Cannabinoid receptor 2 (CB2) DMOKN27 MT DTT DMOKN27 MA Inhibitor DMOKN27 RN Synthesis and pharmacological evaluation of coumarin derivatives as cannabinoid receptor antagonists and inverse agonists. Bioorg Med Chem. 2009 Apr 1;17(7):2842-51. DMOKN27 RU https://pubmed.ncbi.nlm.nih.gov/19278853 DMZ46GI DI DMZ46GI DMZ46GI DN AM-2S DMZ46GI MI TTUZ2L5 DMZ46GI MN Matrix metalloproteinase-3 (MMP-3) DMZ46GI MT DTT DMZ46GI MA Inhibitor DMZ46GI RN Synthesis of hydroxypyrone- and hydroxythiopyrone-based matrix metalloproteinase inhibitors: developing a structure-activity relationship. Bioorg Med Chem Lett. 2009 Apr 1;19(7):1970-6. DMZ46GI RU https://pubmed.ncbi.nlm.nih.gov/19261472 DMZVLJH DI DMZVLJH DMZVLJH DN AM-3701 DMZVLJH MI TTDZN01 DMZVLJH MN Cathepsin K (CTSK) DMZVLJH MT DTT DMZVLJH MA Inhibitor DMZVLJH RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2350). DMZVLJH RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2350 DM2AOF8 DI DM2AOF8 DM2AOF8 DN AM-3840 DM2AOF8 MI TTUMQVO DM2AOF8 MN Cathepsin S (CTSS) DM2AOF8 MT DTT DM2AOF8 MA Inhibitor DM2AOF8 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2353). DM2AOF8 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2353 DMBK9PS DI DMBK9PS DMBK9PS DN AM-404 DMBK9PS MI TT6OEDT DMBK9PS MN Cannabinoid receptor 1 (CB1) DMBK9PS MT DTT DMBK9PS MA Inhibitor DMBK9PS RN Head group analogs of arachidonylethanolamide, the endogenous cannabinoid ligand. J Med Chem. 1996 Oct 25;39(22):4515-9. DMBK9PS RU https://pubmed.ncbi.nlm.nih.gov/8893848 DMBK9PS DI DMBK9PS DMBK9PS DN AM-404 DMBK9PS MI TTMSFAW DMBK9PS MN Cannabinoid receptor 2 (CB2) DMBK9PS MT DTT DMBK9PS MA Inhibitor DMBK9PS RN New analgesics synthetically derived from the paracetamol metabolite N-(4-hydroxyphenyl)-(5Z,8Z,11Z,14Z)-icosatetra-5,8,11,14-enamide. J Med Chem. 2008 Dec 25;51(24):7800-5. DMBK9PS RU https://pubmed.ncbi.nlm.nih.gov/19053765 DMBK9PS DI DMBK9PS DMBK9PS DN AM-404 DMBK9PS MI TTDP1UC DMBK9PS MN Fatty acid amide hydrolase (FAAH) DMBK9PS MT DTT DMBK9PS MA Inhibitor DMBK9PS RN New analgesics synthetically derived from the paracetamol metabolite N-(4-hydroxyphenyl)-(5Z,8Z,11Z,14Z)-icosatetra-5,8,11,14-enamide. J Med Chem. 2008 Dec 25;51(24):7800-5. DMBK9PS RU https://pubmed.ncbi.nlm.nih.gov/19053765 DMU3Y4J DI DMU3Y4J DMU3Y4J DN AM-411 DMU3Y4J MI TT6OEDT DMU3Y4J MN Cannabinoid receptor 1 (CB1) DMU3Y4J MT DTT DMU3Y4J MA Inhibitor DMU3Y4J RN Heteroadamantyl cannabinoids. J Med Chem. 2010 Aug 12;53(15):5656-66. DMU3Y4J RU https://pubmed.ncbi.nlm.nih.gov/20593789 DMU3Y4J DI DMU3Y4J DMU3Y4J DN AM-411 DMU3Y4J MI TTMSFAW DMU3Y4J MN Cannabinoid receptor 2 (CB2) DMU3Y4J MT DTT DMU3Y4J MA Inhibitor DMU3Y4J RN Heteroadamantyl cannabinoids. J Med Chem. 2010 Aug 12;53(15):5656-66. DMU3Y4J RU https://pubmed.ncbi.nlm.nih.gov/20593789 DMETXA8 DI DMETXA8 DMETXA8 DN AM-4768 DMETXA8 MI TT6OEDT DMETXA8 MN Cannabinoid receptor 1 (CB1) DMETXA8 MT DTT DMETXA8 MA Inhibitor DMETXA8 RN Cannabilactones: a novel class of CB2 selective agonists with peripheral analgesic activity. J Med Chem. 2007 Dec 27;50(26):6493-500. DMETXA8 RU https://pubmed.ncbi.nlm.nih.gov/18038967 DMETXA8 DI DMETXA8 DMETXA8 DN AM-4768 DMETXA8 MI TTMSFAW DMETXA8 MN Cannabinoid receptor 2 (CB2) DMETXA8 MT DTT DMETXA8 MA Inhibitor DMETXA8 RN Cannabilactones: a novel class of CB2 selective agonists with peripheral analgesic activity. J Med Chem. 2007 Dec 27;50(26):6493-500. DMETXA8 RU https://pubmed.ncbi.nlm.nih.gov/18038967 DM7R605 DI DM7R605 DM7R605 DN AM-630 DM7R605 MI TT6OEDT DM7R605 MN Cannabinoid receptor 1 (CB1) DM7R605 MT DTT DM7R605 MA Inhibitor DM7R605 RN New 1,8-naphthyridine and quinoline derivatives as CB2 selective agonists. Bioorg Med Chem Lett. 2007 Dec 1;17(23):6505-10. DM7R605 RU https://pubmed.ncbi.nlm.nih.gov/17942307 DM7R605 DI DM7R605 DM7R605 DN AM-630 DM7R605 MI TTMSFAW DM7R605 MN Cannabinoid receptor 2 (CB2) DM7R605 MT DTT DM7R605 MA Inhibitor DM7R605 RN New 1,8-naphthyridine and quinoline derivatives as CB2 selective agonists. Bioorg Med Chem Lett. 2007 Dec 1;17(23):6505-10. DM7R605 RU https://pubmed.ncbi.nlm.nih.gov/17942307 DMYVQFN DI DMYVQFN DMYVQFN DN AM7 DMYVQFN MI TTNDSF4 DMYVQFN MN Proto-oncogene c-Met (MET) DMYVQFN MT DTT DMYVQFN MA Inhibitor DMYVQFN RN c-Met inhibitors with novel binding mode show activity against several hereditary papillary renal cell carcinoma-related mutations. J Biol Chem. 2008 Feb 1;283(5):2675-83. DMYVQFN RU https://pubmed.ncbi.nlm.nih.gov/18055465 DM5JZUB DI DM5JZUB DM5JZUB DN AMA DM5JZUB MI TTV9GOF DM5JZUB MN Histidine decarboxylase (HDC) DM5JZUB MT DTT DM5JZUB MA Inhibitor DM5JZUB RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1274). DM5JZUB RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1274 DMW9TRD DI DMW9TRD DMW9TRD DN AMA-237 DMW9TRD MI TTZN7RP DMW9TRD MN Rho-associated protein kinase 1 (ROCK1) DMW9TRD MT DTT DMW9TRD MA Inhibitor DMW9TRD RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1503). DMW9TRD RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1503 DMW9TRD DI DMW9TRD DMW9TRD DN AMA-237 DMW9TRD MI TTGWKQJ DMW9TRD MN Rho-associated protein kinase 2 (ROCK2) DMW9TRD MT DTT DMW9TRD MA Inhibitor DMW9TRD RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1504). DMW9TRD RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1504 DMIZQOG DI DMIZQOG DMIZQOG DN AMA37 DMIZQOG MI TTK3PY9 DMIZQOG MN DNA-dependent protein kinase catalytic (PRKDC) DMIZQOG MT DTT DMIZQOG MA Inhibitor DMIZQOG RN Inhibition of mammalian target of rapamycin signaling by 2-(morpholin-1-yl)pyrimido[2,1-alpha]isoquinolin-4-one. J Biol Chem. 2007 Aug 17;282(33):24463-70. DMIZQOG RU https://pubmed.ncbi.nlm.nih.gov/17562705 DM59IT4 DI DM59IT4 DM59IT4 DN Amanitin DM59IT4 MI DT9C1TS DM59IT4 MN Organic anion transporting polypeptide 1B3 (SLCO1B3) DM59IT4 MT DTP DM59IT4 MA Substrate DM59IT4 RN Molecular characterization and inhibition of amanitin uptake into human hepatocytes. Toxicol Sci. 2006 May;91(1):140-9. DM59IT4 RU http://www.ncbi.nlm.nih.gov/pubmed/16495352 DML9W2V DI DML9W2V DML9W2V DN Amarylline DML9W2V MI TTOA6YT DML9W2V MN MERS-CoV RNA-directed RNA polymerase (RdRp) DML9W2V MT DTT DML9W2V MA Inhibitor DML9W2V RN Lycorine: A prospective natural lead for anticancer drug discovery. Biomed Pharmacother. 2018 Nov;107:615-624. DML9W2V RU https://pubmed.ncbi.nlm.nih.gov/30114645 DMAVC9T DI DMAVC9T DMAVC9T DN AMBAZONE DMAVC9T MI TTUTN1I DMAVC9T MN Human Deoxyribonucleic acid (hDNA) DMAVC9T MT DTT DMAVC9T MA Binder DMAVC9T RN Ambazone as a membrane active antitumor drug. Biophys Chem. 1990 Apr;35(2-3):287-300. DMAVC9T RU https://pubmed.ncbi.nlm.nih.gov/2204445 DM75UK8 DI DM75UK8 DM75UK8 DN AMD3101 DM75UK8 MI TT2BVUA DM75UK8 MN C-X-C chemokine receptor type 6 (CXCR6) DM75UK8 MT DTT DM75UK8 MA Antagonist DM75UK8 RN Opportunities and challenges in targeting HIV entry. Curr Opin Pharmacol. 2002 Oct;2(5):529-33. DM75UK8 RU https://pubmed.ncbi.nlm.nih.gov/12324254 DMLRNV2 DI DMLRNV2 DMLRNV2 DN AMENTOFLAVONE DMLRNV2 MI TT1MPAY DMLRNV2 MN GABA(A) receptor alpha-1 (GABRA1) DMLRNV2 MT DTT DMLRNV2 MA Inhibitor DMLRNV2 RN Semisynthetic preparation of amentoflavone: A negative modulator at GABA(A) receptors. Bioorg Med Chem Lett. 2003 Jul 21;13(14):2281-4. DMLRNV2 RU https://pubmed.ncbi.nlm.nih.gov/12824018 DMLRNV2 DI DMLRNV2 DMLRNV2 DN AMENTOFLAVONE DMLRNV2 MI TTBMV1G DMLRNV2 MN GABA(A) receptor alpha-2 (GABRA2) DMLRNV2 MT DTT DMLRNV2 MA Inhibitor DMLRNV2 RN Semisynthetic preparation of amentoflavone: A negative modulator at GABA(A) receptors. Bioorg Med Chem Lett. 2003 Jul 21;13(14):2281-4. DMLRNV2 RU https://pubmed.ncbi.nlm.nih.gov/12824018 DMLRNV2 DI DMLRNV2 DMLRNV2 DN AMENTOFLAVONE DMLRNV2 MI TT37EDJ DMLRNV2 MN GABA(A) receptor alpha-3 (GABRA3) DMLRNV2 MT DTT DMLRNV2 MA Inhibitor DMLRNV2 RN Semisynthetic preparation of amentoflavone: A negative modulator at GABA(A) receptors. Bioorg Med Chem Lett. 2003 Jul 21;13(14):2281-4. DMLRNV2 RU https://pubmed.ncbi.nlm.nih.gov/12824018 DMLRNV2 DI DMLRNV2 DMLRNV2 DN AMENTOFLAVONE DMLRNV2 MI TTNZPQ1 DMLRNV2 MN GABA(A) receptor alpha-5 (GABRA5) DMLRNV2 MT DTT DMLRNV2 MA Inhibitor DMLRNV2 RN Semisynthetic preparation of amentoflavone: A negative modulator at GABA(A) receptors. Bioorg Med Chem Lett. 2003 Jul 21;13(14):2281-4. DMLRNV2 RU https://pubmed.ncbi.nlm.nih.gov/12824018 DMLRNV2 DI DMLRNV2 DMLRNV2 DN AMENTOFLAVONE DMLRNV2 MI TTZA1NY DMLRNV2 MN GABA(A) receptor beta-2 (GABRB2) DMLRNV2 MT DTT DMLRNV2 MA Inhibitor DMLRNV2 RN Semisynthetic preparation of amentoflavone: A negative modulator at GABA(A) receptors. Bioorg Med Chem Lett. 2003 Jul 21;13(14):2281-4. DMLRNV2 RU https://pubmed.ncbi.nlm.nih.gov/12824018 DMLRNV2 DI DMLRNV2 DMLRNV2 DN AMENTOFLAVONE DMLRNV2 MI TT06RH5 DMLRNV2 MN GABA(A) receptor gamma-2 (GABRG2) DMLRNV2 MT DTT DMLRNV2 MA Inhibitor DMLRNV2 RN Semisynthetic preparation of amentoflavone: A negative modulator at GABA(A) receptors. Bioorg Med Chem Lett. 2003 Jul 21;13(14):2281-4. DMLRNV2 RU https://pubmed.ncbi.nlm.nih.gov/12824018 DMLRNV2 DI DMLRNV2 DMLRNV2 DN AMENTOFLAVONE DMLRNV2 MI TTNJYV2 DMLRNV2 MN Gamma-aminobutyric acid receptor (GAR) DMLRNV2 MT DTT DMLRNV2 MA Inhibitor DMLRNV2 RN Semisynthetic preparation of amentoflavone: A negative modulator at GABA(A) receptors. Bioorg Med Chem Lett. 2003 Jul 21;13(14):2281-4. DMLRNV2 RU https://pubmed.ncbi.nlm.nih.gov/12824018 DMLRNV2 DI DMLRNV2 DMLRNV2 DN AMENTOFLAVONE DMLRNV2 MI TTL53M6 DMLRNV2 MN Induced myeloid leukemia cell differentiation protein Mcl-1 (MCL1) DMLRNV2 MT DTT DMLRNV2 MA Inhibitor DMLRNV2 RN In silico identification and biochemical evaluation of novel inhibitors of NRH:quinone oxidoreductase 2 (NQO2). Bioorg Med Chem Lett. 2010 Dec 15;20(24):7331-6. DMLRNV2 RU https://pubmed.ncbi.nlm.nih.gov/21074425 DMLRNV2 DI DMLRNV2 DMLRNV2 DN AMENTOFLAVONE DMLRNV2 MI TT7RJY8 DMLRNV2 MN Xanthine dehydrogenase/oxidase (XDH) DMLRNV2 MT DTT DMLRNV2 MA Inhibitor DMLRNV2 RN Inhibition of cow's milk xanthine oxidase by flavonoids. J Nat Prod. 1988 Mar-Apr;51(2):345-8. DMLRNV2 RU https://pubmed.ncbi.nlm.nih.gov/3379415 DMDRSFE DI DMDRSFE DMDRSFE DN Ametantrone DMDRSFE MI TT0IHXV DMDRSFE MN DNA topoisomerase II (TOP2) DMDRSFE MT DTT DMDRSFE MA Intercalator DMDRSFE RN Interactions of antitumor agents Ametantrone and Mitoxantrone (Novatrone) with double-stranded DNA. Biochem Pharmacol. 1985 Dec 15;34(24):4203-13. DMDRSFE RU https://pubmed.ncbi.nlm.nih.gov/4074383 DM589XV DI DM589XV DM589XV DN AMG 9810 DM589XV MI TTMI6F5 DM589XV MN Transient receptor potential cation channel V1 (TRPV1) DM589XV MT DTT DM589XV MA Blocker (channel blocker) DM589XV RN AMG 9810 [(E)-3-(4-t-butylphenyl)-N-(2,3-dihydrobenzo[b][1,4] dioxin-6-yl)acrylamide], a novel vanilloid receptor 1 (TRPV1) antagonist with antihyp... J Pharmacol Exp Ther. 2005 Apr;313(1):474-84. DM589XV RU https://pubmed.ncbi.nlm.nih.gov/15615864 DMUONK5 DI DMUONK5 DMUONK5 DN amg-1 DMUONK5 MI TTZJYKH DMUONK5 MN Indoleamine 2,3-dioxygenase 1 (IDO1) DMUONK5 MT DTT DMUONK5 MA Inhibitor DMUONK5 RN Purification and kinetic characterization of human indoleamine 2,3-dioxygenases 1 and 2 (IDO1 and IDO2) and discovery of selective IDO1 inhibitors. Biochim Biophys Acta. 2011 Dec;1814(12):1947-54. DMUONK5 RU https://pubmed.ncbi.nlm.nih.gov/21835273 DM9H7AZ DI DM9H7AZ DM9H7AZ DN AMG-126737 DM9H7AZ MI TTM1TDX DM9H7AZ MN Tryptase alpha/beta-1 (Tryptase) DM9H7AZ MT DTT DM9H7AZ MA Inhibitor DM9H7AZ RN Tryptase inhibition blocks airway inflammation in a mouse asthma model. J Immunol. 2002 Feb 15;168(4):1992-2000. DM9H7AZ RU https://pubmed.ncbi.nlm.nih.gov/11823536 DMU6WR9 DI DMU6WR9 DMU6WR9 DN AMG-247 DMU6WR9 MI TT9JZCK DMU6WR9 MN Sphingosine-1-phosphate receptor 1 (S1PR1) DMU6WR9 MT DTT DMU6WR9 MA Antagonist DMU6WR9 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 275). DMU6WR9 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=275 DMRD83Q DI DMRD83Q DMRD83Q DN AMG-2504 DMRD83Q MI TTELV3W DMRD83Q MN Transformation-sensitive protein p120 (TRPA1) DMRD83Q MT DTT DMRD83Q MA Inhibitor DMRD83Q RN Transient receptor potential ankyrin 1 (TRPA1) channel as emerging target for novel analgesics and anti-inflammatory agents. J Med Chem. 2010 Jul 22;53(14):5085-107. DMRD83Q RU https://pubmed.ncbi.nlm.nih.gov/20356305 DME04BH DI DME04BH DME04BH DN AMG-429 DME04BH MI TTUTJGQ DME04BH MN Vascular endothelial growth factor receptor 2 (KDR) DME04BH MT DTT DME04BH MA Inhibitor DME04BH RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1813). DME04BH RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1813 DMNEVXT DI DMNEVXT DMNEVXT DN AMG-5445 DMNEVXT MI TTELV3W DMNEVXT MN Transformation-sensitive protein p120 (TRPA1) DMNEVXT MT DTT DMNEVXT MA Inhibitor DMNEVXT RN Transient receptor potential ankyrin 1 (TRPA1) channel as emerging target for novel analgesics and anti-inflammatory agents. J Med Chem. 2010 Jul 22;53(14):5085-107. DMNEVXT RU https://pubmed.ncbi.nlm.nih.gov/20356305 DMI39YX DI DMI39YX DMI39YX DN AMG-628 DMI39YX MI TTMI6F5 DMI39YX MN Transient receptor potential cation channel V1 (TRPV1) DMI39YX MT DTT DMI39YX MA Inhibitor DMI39YX RN Novel vanilloid receptor-1 antagonists: 3. The identification of a second-generation clinical candidate with improved physicochemical and pharmacok... J Med Chem. 2007 Jul 26;50(15):3528-39. DMI39YX RU https://pubmed.ncbi.nlm.nih.gov/17585751 DMEVNZI DI DMEVNZI DMEVNZI DN AMG-7160 DMEVNZI MI TTELV3W DMEVNZI MN Transformation-sensitive protein p120 (TRPA1) DMEVNZI MT DTT DMEVNZI MA Inhibitor DMEVNZI RN Transient receptor potential ankyrin 1 (TRPA1) channel as emerging target for novel analgesics and anti-inflammatory agents. J Med Chem. 2010 Jul 22;53(14):5085-107. DMEVNZI RU https://pubmed.ncbi.nlm.nih.gov/20356305 DMJ6L9U DI DMJ6L9U DMJ6L9U DN AMG7703 DMJ6L9U MI TT0FYAN DMJ6L9U MN Free fatty acid receptor 2 (FFAR2) DMJ6L9U MT DTT DMJ6L9U MA Modulator (allosteric modulator) DMJ6L9U RN Extracellular loop 2 of the free fatty acid receptor 2 mediates allosterism of a phenylacetamide ago-allosteric modulator. Mol Pharmacol. 2011 Jul;80(1):163-73. DMJ6L9U RU https://pubmed.ncbi.nlm.nih.gov/21498659 DMNHM1B DI DMNHM1B DMNHM1B DN AMG-837 DMNHM1B MI TTB8FUC DMNHM1B MN Free fatty acid receptor 1 (GPR40) DMNHM1B MT DTT DMNHM1B MA Agonist DMNHM1B RN Identification and pharmacological characterization of multiple allosteric binding sites on the free fatty acid 1 receptor. Mol Pharmacol. 2012 Nov;82(5):843-59. DMNHM1B RU https://pubmed.ncbi.nlm.nih.gov/22859723 DMU8M0I DI DMU8M0I DMU8M0I DN AMG-8563 DMU8M0I MI TTMI6F5 DMU8M0I MN Transient receptor potential cation channel V1 (TRPV1) DMU8M0I MT DTT DMU8M0I MA Blocker DMU8M0I RN Analgesic potential of TRPV1 antagonists. Biochem Pharmacol. 2009 Aug 1;78(3):211-6. DMU8M0I RU https://pubmed.ncbi.nlm.nih.gov/19481638 DMKP8L9 DI DMKP8L9 DMKP8L9 DN AMG-889436 DMKP8L9 MI TTPJR0G DMKP8L9 MN Glutamate receptor AMPA 4 (GRIA4) DMKP8L9 MT DTT DMKP8L9 MA Agonist DMKP8L9 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 447). DMKP8L9 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=447 DM1J46S DI DM1J46S DM1J46S DN AMG-9090 DM1J46S MI TTELV3W DM1J46S MN Transformation-sensitive protein p120 (TRPA1) DM1J46S MT DTT DM1J46S MA Inhibitor DM1J46S RN Transient receptor potential ankyrin 1 (TRPA1) channel as emerging target for novel analgesics and anti-inflammatory agents. J Med Chem. 2010 Jul 22;53(14):5085-107. DM1J46S RU https://pubmed.ncbi.nlm.nih.gov/20356305 DMSQ49N DI DMSQ49N DMSQ49N DN AMG-JAK2-01 DMSQ49N MI TTRMX3V DMSQ49N MN Janus kinase 2 (JAK-2) DMSQ49N MT DTT DMSQ49N MA Inhibitor DMSQ49N RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2048). DMSQ49N RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2048 DM4MXOB DI DM4MXOB DM4MXOB DN AMI-1 DM4MXOB MI TTVOJAI DM4MXOB MN Protein arginine methyltransferase 1 (PRMT1) DM4MXOB MT DTT DM4MXOB MA Inhibitor DM4MXOB RN Small molecule regulators of protein arginine methyltransferases. J Biol Chem. 2004 Jun 4;279(23):23892-9. DM4MXOB RU https://pubmed.ncbi.nlm.nih.gov/15056663 DMST5VW DI DMST5VW DMST5VW DN amidephrine DMST5VW MI TT2NUT5 DMST5VW MN Adrenergic receptor alpha-2C (ADRA2C) DMST5VW MT DTT DMST5VW MA Agonist DMST5VW RN Selectivity of agonists for cloned alpha 1-adrenergic receptor subtypes. Mol Pharmacol. 1994 Nov;46(5):929-36. DMST5VW RU https://pubmed.ncbi.nlm.nih.gov/7969082 DMJ0BEG DI DMJ0BEG DMJ0BEG DN AMIFLAMINE DMJ0BEG MI TTAWNKZ DMJ0BEG MN Norepinephrine transporter (NET) DMJ0BEG MT DTT DMJ0BEG MA Inhibitor DMJ0BEG RN Selective monoamine oxidase inhibitors. 3. Cyclic compounds related to 4-aminophenethylamine. Preparation and neuron-selective action of some 5-(2-... J Med Chem. 1986 Aug;29(8):1406-12. DMJ0BEG RU https://pubmed.ncbi.nlm.nih.gov/3735309 DMNGW2M DI DMNGW2M DMNGW2M DN Aminobenzoic acid DMNGW2M MI DEZV4AP DMNGW2M MN RNA cytidine acetyltransferase (hALP) DMNGW2M MT DME DMNGW2M MA Metabolism DMNGW2M RN Leukemia inhibitory factor decreases the arylamine N-acetyltransferase activity in human cumulus granulosa cells. J Assist Reprod Genet. 2001 Dec;18(12):660-4. DMNGW2M RU https://www.ncbi.nlm.nih.gov/pubmed/?term=11808848 DMNGW2M DI DMNGW2M DMNGW2M DN Aminobenzoic acid DMNGW2M MI DEYWLRK DMNGW2M MN Sulfotransferase 1A1 (SULT1A1) DMNGW2M MT DME DMNGW2M MA Metabolism DMNGW2M RN Activities of drug metabolizing enzymes in bovine colon epithelial cell cultures. Arch Toxicol. 2003 Nov;77(11):621-9. DMNGW2M RU https://www.ncbi.nlm.nih.gov/pubmed/?term=14508638 DMWYS0Z DI DMWYS0Z DMWYS0Z DN Aminobenzolamide derivative DMWYS0Z MI TTHQPL7 DMWYS0Z MN Carbonic anhydrase I (CA-I) DMWYS0Z MT DTT DMWYS0Z MA Inhibitor DMWYS0Z RN Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, and IX with sulfonamides d... Bioorg Med Chem Lett. 2004 Dec 6;14(23):5775-80. DMWYS0Z RU https://pubmed.ncbi.nlm.nih.gov/15501039 DMWYS0Z DI DMWYS0Z DMWYS0Z DN Aminobenzolamide derivative DMWYS0Z MI TTANPDJ DMWYS0Z MN Carbonic anhydrase II (CA-II) DMWYS0Z MT DTT DMWYS0Z MA Inhibitor DMWYS0Z RN Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, and IX with sulfonamides d... Bioorg Med Chem Lett. 2004 Dec 6;14(23):5775-80. DMWYS0Z RU https://pubmed.ncbi.nlm.nih.gov/15501039 DMWYS0Z DI DMWYS0Z DMWYS0Z DN Aminobenzolamide derivative DMWYS0Z MI TT2LVK8 DMWYS0Z MN Carbonic anhydrase IX (CA-IX) DMWYS0Z MT DTT DMWYS0Z MA Inhibitor DMWYS0Z RN Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, and IX with sulfonamides d... Bioorg Med Chem Lett. 2004 Dec 6;14(23):5775-80. DMWYS0Z RU https://pubmed.ncbi.nlm.nih.gov/15501039 DMCILV7 DI DMCILV7 DMCILV7 DN aminobenzovesamicol DMCILV7 MI TTV8KWS DMCILV7 MN Vesicular acetylcholine transporter (SLC18A3) DMCILV7 MT DTT DMCILV7 MA Inhibitor DMCILV7 RN Vesamicol analogues as sigma ligands. Molecular determinants of selectivity at the vesamicol receptor. Biochem Pharmacol. 1995 Mar 15;49(6):791-7. DMCILV7 RU https://pubmed.ncbi.nlm.nih.gov/7702637 DMT13EW DI DMT13EW DMT13EW DN AMINOBENZTROPINE DMT13EW MI TTVBI8W DMT13EW MN Dopamine transporter (DAT) DMT13EW MT DTT DMT13EW MA Inhibitor DMT13EW RN 3'-Chloro-3 alpha-(diphenylmethoxy)tropane but not 4'-chloro-3 alpha-(diphenylmethoxy)tropane produces a cocaine-like behavioral profile. J Med Chem. 1997 Mar 14;40(6):851-7. DMT13EW RU https://pubmed.ncbi.nlm.nih.gov/9083473 DMT13EW DI DMT13EW DMT13EW DN AMINOBENZTROPINE DMT13EW MI TTZ9SOR DMT13EW MN Muscarinic acetylcholine receptor M1 (CHRM1) DMT13EW MT DTT DMT13EW MA Inhibitor DMT13EW RN 3'-Chloro-3 alpha-(diphenylmethoxy)tropane but not 4'-chloro-3 alpha-(diphenylmethoxy)tropane produces a cocaine-like behavioral profile. J Med Chem. 1997 Mar 14;40(6):851-7. DMT13EW RU https://pubmed.ncbi.nlm.nih.gov/9083473 DMCLVOZ DI DMCLVOZ DMCLVOZ DN Aminocarbonyl dihydrogen phosphate DMCLVOZ MI TTZHA0O DMCLVOZ MN Carbonic anhydrase IV (CA-IV) DMCLVOZ MT DTT DMCLVOZ MA Inhibitor DMCLVOZ RN Carbonic anhydrase inhibitors. Interaction of isozymes I, II, IV, V, and IX with organic phosphates and phosphonates. Bioorg Med Chem Lett. 2005 Mar 15;15(6):1683-6. DMCLVOZ RU https://pubmed.ncbi.nlm.nih.gov/15745821 DM79E2K DI DM79E2K DM79E2K DN Aminodeoxykanamycin DM79E2K MI TT38DW5 DM79E2K MN Bacterial 16S ribosomal RNA (Bact 16S rRNA) DM79E2K MT DTT DM79E2K MA Inhibitor DM79E2K RN RNA as a target for small molecules. Curr Opin Chem Biol. 2000 Dec;4(6):678-86. DM79E2K RU https://pubmed.ncbi.nlm.nih.gov/11102874 DM7Y6AL DI DM7Y6AL DM7Y6AL DN AMINOFENTANYL DM7Y6AL MI TT27RFC DM7Y6AL MN Opioid receptor delta (OPRD1) DM7Y6AL MT DTT DM7Y6AL MA Inhibitor DM7Y6AL RN Synthesis and evaluation of 3-aminopropionyl substituted fentanyl analogues for opioid activity. Bioorg Med Chem Lett. 2006 Sep 15;16(18):4946-50. DM7Y6AL RU https://pubmed.ncbi.nlm.nih.gov/16828552 DM7Y6AL DI DM7Y6AL DM7Y6AL DN AMINOFENTANYL DM7Y6AL MI TTKWM86 DM7Y6AL MN Opioid receptor mu (MOP) DM7Y6AL MT DTT DM7Y6AL MA Inhibitor DM7Y6AL RN Synthesis and evaluation of 3-aminopropionyl substituted fentanyl analogues for opioid activity. Bioorg Med Chem Lett. 2006 Sep 15;16(18):4946-50. DM7Y6AL RU https://pubmed.ncbi.nlm.nih.gov/16828552 DMUN54G DI DMUN54G DMUN54G DN Aminohippuric acid DMUN54G MI DT9NXMV DMUN54G MN ATP-binding cassette sub-family A member 8 (ABCA8) DMUN54G MT DTP DMUN54G MA Substrate DMUN54G RN Functional analysis of ABCA8, a new drug transporter. Biochem Biophys Res Commun. 2002 Oct 18;298(1):41-5. DMUN54G RU http://www.ncbi.nlm.nih.gov/pubmed/12379217 DMUN54G DI DMUN54G DMUN54G DN Aminohippuric acid DMUN54G MI DTSYQGK DMUN54G MN Multidrug resistance-associated protein 1 (ABCC1) DMUN54G MT DTP DMUN54G MA Substrate DMUN54G RN ATP-dependent para-aminohippurate transport by apical multidrug resistance protein MRP2. Kidney Int. 2000 Apr;57(4):1636-42. DMUN54G RU http://www.ncbi.nlm.nih.gov/pubmed/10760098 DMUN54G DI DMUN54G DMUN54G DN Aminohippuric acid DMUN54G MI DTFI42L DMUN54G MN Multidrug resistance-associated protein 2 (ABCC2) DMUN54G MT DTP DMUN54G MA Substrate DMUN54G RN ATP-dependent para-aminohippurate transport by apical multidrug resistance protein MRP2. Kidney Int. 2000 Apr;57(4):1636-42. DMUN54G RU http://www.ncbi.nlm.nih.gov/pubmed/10760098 DMUN54G DI DMUN54G DMUN54G DN Aminohippuric acid DMUN54G MI DTCSGPB DMUN54G MN Multidrug resistance-associated protein 4 (ABCC4) DMUN54G MT DTP DMUN54G MA Substrate DMUN54G RN Contribution of multidrug resistance protein 2 (MRP2/ABCC2) to the renal excretion of p-aminohippurate (PAH) and identification of MRP4 (ABCC4) as a novel PAH transporter. J Am Soc Nephrol. 2004 Nov;15(11):2828-35. DMUN54G RU http://www.ncbi.nlm.nih.gov/pubmed/15504935 DMUN54G DI DMUN54G DMUN54G DN Aminohippuric acid DMUN54G MI DTQ23VB DMUN54G MN Organic anion transporter 1 (SLC22A6) DMUN54G MT DTP DMUN54G MA Substrate DMUN54G RN Interactions of human organic anion transporter 1 (hOAT1) with substances associated with forensic toxicology. Leg Med (Tokyo). 2011 Jul;13(4):180-5. DMUN54G RU http://www.ncbi.nlm.nih.gov/pubmed/21561794 DMUN54G DI DMUN54G DMUN54G DN Aminohippuric acid DMUN54G MI DTVP67E DMUN54G MN Organic anion transporter 3 (SLC22A8) DMUN54G MT DTP DMUN54G MA Substrate DMUN54G RN Identification and characterization of human organic anion transporter 3 expressing predominantly in the kidney. Mol Pharmacol. 2001 May;59(5):1277-86. DMUN54G RU http://www.ncbi.nlm.nih.gov/pubmed/11306713 DMUN54G DI DMUN54G DMUN54G DN Aminohippuric acid DMUN54G MI DTE2B1D DMUN54G MN Organic anion transporting polypeptide 1A2 (SLCO1A2) DMUN54G MT DTP DMUN54G MA Substrate DMUN54G RN Characterization and identification of steroid sulfate transporters of human placenta. Am J Physiol Endocrinol Metab. 2003 Feb;284(2):E390-8. DMUN54G RU http://ajpendo.physiology.org/content/284/2/E390.full DMUN54G DI DMUN54G DMUN54G DN Aminohippuric acid DMUN54G MI DTRF4L3 DMUN54G MN Sodium-dependent phosphate transport protein 3 (SLC17A2) DMUN54G MT DTP DMUN54G MA Substrate DMUN54G RN Wide expression of type I Na+-phosphate cotransporter 3 (NPT3/SLC17A2), a membrane potential-driven organic anion transporter. Am J Physiol Cell Physiol. 2015 Jul 15;309(2):C71-80. DMUN54G RU http://www.ncbi.nlm.nih.gov/pubmed/25972451 DMUN54G DI DMUN54G DMUN54G DN Aminohippuric acid DMUN54G MI DTFOJL7 DMUN54G MN Sodium-dependent phosphate transport protein 4 (SLC17A3) DMUN54G MT DTP DMUN54G MA Substrate DMUN54G RN Human sodium phosphate transporter 4 (hNPT4/SLC17A3) as a common renal secretory pathway for drugs and urate. J Biol Chem. 2010 Nov 5;285(45):35123-32. DMUN54G RU http://www.ncbi.nlm.nih.gov/pubmed/20810651 DMUN54G DI DMUN54G DMUN54G DN Aminohippuric acid DMUN54G MI TTTQR47 DMUN54G MN Solute carrier family 22 member 8 (SLC22A8) DMUN54G MT DTT DMUN54G MA Inhibitor DMUN54G RN Structural variation governs substrate specificity for organic anion transporter (OAT) homologs. Potential remote sensing by OAT family members. J Biol Chem. 2007 Aug 17;282(33):23841-53. DMUN54G RU https://pubmed.ncbi.nlm.nih.gov/17553798 DMNX9FC DI DMNX9FC DMNX9FC DN Aminomethylcyclohexane DMNX9FC MI TTICX3S DMNX9FC MN Bacterial UDP-N-acetylglucosamine carboxyvinyltransferase (Bact murA) DMNX9FC MT DTT DMNX9FC MA Inhibitor DMNX9FC RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMNX9FC RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMHNDTW DI DMHNDTW DMHNDTW DN aminooxyacetic acid DMHNDTW MI TTVZJ7G DMHNDTW MN Cystathionine beta-synthase (CBS) DMHNDTW MT DTT DMHNDTW MA Inhibitor DMHNDTW RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1443). DMHNDTW RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1443 DMHNDTW DI DMHNDTW DMHNDTW DN aminooxyacetic acid DMHNDTW MI TTU507L DMHNDTW MN Cytoplasmic aspartate aminotransferase (GOT1) DMHNDTW MT DTT DMHNDTW MA Inhibitor DMHNDTW RN Aspartate aminotransferase isotope exchange reactions: implications for glutamate/glutamine shuttle hypothesis. Am J Physiol Cell Physiol. 2002 Jun;282(6):C1404-13. DMHNDTW RU https://pubmed.ncbi.nlm.nih.gov/11997255 DMEMCQ9 DI DMEMCQ9 DMEMCQ9 DN Aminophenol DMEMCQ9 MI DED5UR3 DMEMCQ9 MN Sulfotransferase 1B1 (SULT1B1) DMEMCQ9 MT DME DMEMCQ9 MA Metabolism DMEMCQ9 RN Comparison of 2-aminophenol and 4-nitrophenol as in vitro probe substrates for the major human hepatic sulfotransferase, SULT1A1, demonstrates improved selectivity with 2-aminophenol. Biochem Pharmacol. 2007 Jul 15;74(2):352-8. DMEMCQ9 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=17506995 DMT5HOA DI DMT5HOA DMT5HOA DN amino-propylphosphinic acid DMT5HOA MI TTDCVZW DMT5HOA MN Gamma-aminobutyric acid B receptor (GABBR) DMT5HOA MT DTT DMT5HOA MA Agonist DMT5HOA RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 242). DMT5HOA RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=242 DMKLC3O DI DMKLC3O DMKLC3O DN aminopurvalanol A DMKLC3O MI TTH6V3D DMKLC3O MN Cyclin-dependent kinase 1 (CDK1) DMKLC3O MT DTT DMKLC3O MA Inhibitor DMKLC3O RN A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases. Proc Natl Acad Sci U S A. 2007 Dec 18;104(51):20523-8. DMKLC3O RU https://pubmed.ncbi.nlm.nih.gov/18077363 DMKLC3O DI DMKLC3O DMKLC3O DN aminopurvalanol A DMKLC3O MI TT7HF4W DMKLC3O MN Cyclin-dependent kinase 2 (CDK2) DMKLC3O MT DTT DMKLC3O MA Inhibitor DMKLC3O RN A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases. Proc Natl Acad Sci U S A. 2007 Dec 18;104(51):20523-8. DMKLC3O RU https://pubmed.ncbi.nlm.nih.gov/18077363 DMKLC3O DI DMKLC3O DMKLC3O DN aminopurvalanol A DMKLC3O MI TTL4Q97 DMKLC3O MN Cyclin-dependent kinase 5 (CDK5) DMKLC3O MT DTT DMKLC3O MA Inhibitor DMKLC3O RN A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases. Proc Natl Acad Sci U S A. 2007 Dec 18;104(51):20523-8. DMKLC3O RU https://pubmed.ncbi.nlm.nih.gov/18077363 DM94KQP DI DM94KQP DM94KQP DN Aminopyridine deriv. 2 DM94KQP MI TT3IVG2 DM94KQP MN JNK2 messenger RNA (JNK2 mRNA) DM94KQP MT DTT DM94KQP MA Inhibitor DM94KQP RN Aminopyridine-based c-Jun N-terminal kinase inhibitors with cellular activity and minimal cross-kinase activity. J Med Chem. 2006 Jun 15;49(12):3563-80. DM94KQP RU https://pubmed.ncbi.nlm.nih.gov/16759099 DM94KQP DI DM94KQP DM94KQP DN Aminopyridine deriv. 2 DM94KQP MI TT0K6EO DM94KQP MN Stress-activated protein kinase JNK1 (JNK1) DM94KQP MT DTT DM94KQP MA Inhibitor DM94KQP RN Aminopyridine-based c-Jun N-terminal kinase inhibitors with cellular activity and minimal cross-kinase activity. J Med Chem. 2006 Jun 15;49(12):3563-80. DM94KQP RU https://pubmed.ncbi.nlm.nih.gov/16759099 DM94KQP DI DM94KQP DM94KQP DN Aminopyridine deriv. 2 DM94KQP MI TT056SO DM94KQP MN Stress-activated protein kinase JNK3 (JNK3) DM94KQP MT DTT DM94KQP MA Inhibitor DM94KQP RN Aminopyridine-based c-Jun N-terminal kinase inhibitors with cellular activity and minimal cross-kinase activity. J Med Chem. 2006 Jun 15;49(12):3563-80. DM94KQP RU https://pubmed.ncbi.nlm.nih.gov/16759099 DMGEVBH DI DMGEVBH DMGEVBH DN Aminothiazoline DMGEVBH MI TTF10I9 DMGEVBH MN Nitric-oxide synthase inducible (NOS2) DMGEVBH MT DTT DMGEVBH MA Inhibitor DMGEVBH RN The design, synthesis and biological evaluation of 7-alkoxy-4-heteroarylamino-3-cyanoquinolines as dual inhibitors of c-Src and iNOS. Bioorg Med Chem Lett. 2008 Dec 1;18(23):6206-9. DMGEVBH RU https://pubmed.ncbi.nlm.nih.gov/18930653 DMXDUCP DI DMXDUCP DMXDUCP DN AMN082 DMXDUCP MI TT0I76D DMXDUCP MN Metabotropic glutamate receptor 7 (mGluR7) DMXDUCP MT DTT DMXDUCP MA Modulator (allosteric modulator) DMXDUCP RN A selective metabotropic glutamate receptor 7 agonist: activation of receptor signaling via an allosteric site modulates stress parameters in vivo. Proc Natl Acad Sci U S A. 2005 Dec 20;102(51):18712-7. DMXDUCP RU https://pubmed.ncbi.nlm.nih.gov/16339898 DMC15DM DI DMC15DM DMC15DM DN Amooranin DMC15DM MI TTEVCT0 DMC15DM MN Caspase-8 (CASP8) DMC15DM MT DTT DMC15DM MA Inhibitor DMC15DM RN Glionitrin A, a new diketopiperazine disulfide, activates ATM-ATR-Chk1/2 via 53BP1 phosphorylation in DU145 cells and shows antitumor effect in xenograft model. Biol Pharm Bull. 2014;37(3):378-86. DMC15DM RU https://pubmed.ncbi.nlm.nih.gov/24583858 DM64X25 DI DM64X25 DM64X25 DN AMPE4L DM64X25 MI TTVIMDE DM64X25 MN Glucagon-like peptide 1 receptor (GLP1R) DM64X25 MT DTT DM64X25 MA Modulator DM64X25 RN 2005 approvals: Safety first. Nature Reviews Drug Discovery 5, 92-93 (February 2006). DM64X25 RU http://www.nature.com/nrd/journal/v11/n1/full/nrd3645.html DM64X25 DI DM64X25 DM64X25 DN AMPE4L DM64X25 MI TT0HD6V DM64X25 MN Leptin receptor (LEPR) DM64X25 MT DTT DM64X25 MA Modulator DM64X25 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1712). DM64X25 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1712 DMVHOQE DI DMVHOQE DMVHOQE DN AMPPL DMVHOQE MI TT0HD6V DMVHOQE MN Leptin receptor (LEPR) DMVHOQE MT DTT DMVHOQE MA Modulator DMVHOQE RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1712). DMVHOQE RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1712 DMTOK1D DI DMTOK1D DMTOK1D DN AMP-PNP DMTOK1D MI TTSEOPJ DMTOK1D MN Bacterial Pantothenate kinase (Bact coaA) DMTOK1D MT DTT DMTOK1D MA Inhibitor DMTOK1D RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DMTOK1D RU https://pubmed.ncbi.nlm.nih.gov/10592235 DMTOK1D DI DMTOK1D DMTOK1D DN AMP-PNP DMTOK1D MI TTC0G1L DMTOK1D MN DNA repair protein RAD51 homolog 1 (RAD51) DMTOK1D MT DTT DMTOK1D MA Inhibitor DMTOK1D RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DMTOK1D RU https://pubmed.ncbi.nlm.nih.gov/10592235 DMTOK1D DI DMTOK1D DMTOK1D DN AMP-PNP DMTOK1D MI TT0IHXV DMTOK1D MN DNA topoisomerase II (TOP2) DMTOK1D MT DTT DMTOK1D MA Inhibitor DMTOK1D RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DMTOK1D RU https://pubmed.ncbi.nlm.nih.gov/10592235 DMTOK1D DI DMTOK1D DMTOK1D DN AMP-PNP DMTOK1D MI TT4NVEM DMTOK1D MN DNA topoisomerase II beta (TOP2B) DMTOK1D MT DTT DMTOK1D MA Inhibitor DMTOK1D RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DMTOK1D RU https://pubmed.ncbi.nlm.nih.gov/10592235 DMTOK1D DI DMTOK1D DMTOK1D DN AMP-PNP DMTOK1D MI TTRJB2G DMTOK1D MN Ephrin type-A receptor 2 (EPHA2) DMTOK1D MT DTT DMTOK1D MA Inhibitor DMTOK1D RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DMTOK1D RU https://pubmed.ncbi.nlm.nih.gov/10592235 DMTOK1D DI DMTOK1D DMTOK1D DN AMP-PNP DMTOK1D MI TTKPV6O DMTOK1D MN Ephrin type-B receptor 2 (EPHB2) DMTOK1D MT DTT DMTOK1D MA Inhibitor DMTOK1D RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DMTOK1D RU https://pubmed.ncbi.nlm.nih.gov/10592235 DMTOK1D DI DMTOK1D DMTOK1D DN AMP-PNP DMTOK1D MI TTRSMW9 DMTOK1D MN Glycogen synthase kinase-3 beta (GSK-3B) DMTOK1D MT DTT DMTOK1D MA Inhibitor DMTOK1D RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DMTOK1D RU https://pubmed.ncbi.nlm.nih.gov/10592235 DMTOK1D DI DMTOK1D DMTOK1D DN AMP-PNP DMTOK1D MI TTHRID2 DMTOK1D MN Insulin-like growth factor I receptor (IGF1R) DMTOK1D MT DTT DMTOK1D MA Inhibitor DMTOK1D RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DMTOK1D RU https://pubmed.ncbi.nlm.nih.gov/10592235 DMTOK1D DI DMTOK1D DMTOK1D DN AMP-PNP DMTOK1D MI TT860QF DMTOK1D MN LCK tyrosine protein kinase (LCK) DMTOK1D MT DTT DMTOK1D MA Inhibitor DMTOK1D RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DMTOK1D RU https://pubmed.ncbi.nlm.nih.gov/10592235 DMTOK1D DI DMTOK1D DMTOK1D DN AMP-PNP DMTOK1D MI TTJ2HKA DMTOK1D MN Long transient receptor potential channel 4 (TRPM4) DMTOK1D MT DTT DMTOK1D MA Inhibitor (gating inhibitor) DMTOK1D RN Intracellular nucleotides and polyamines inhibit the Ca2+-activated cation channel TRPM4b. Pflugers Arch. 2004 Apr;448(1):70-5. DMTOK1D RU https://pubmed.ncbi.nlm.nih.gov/14758478 DMTOK1D DI DMTOK1D DMTOK1D DN AMP-PNP DMTOK1D MI TTYT93M DMTOK1D MN MAP kinase p38 (MAPK12) DMTOK1D MT DTT DMTOK1D MA Inhibitor DMTOK1D RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DMTOK1D RU https://pubmed.ncbi.nlm.nih.gov/10592235 DMTOK1D DI DMTOK1D DMTOK1D DN AMP-PNP DMTOK1D MI TT5B8AX DMTOK1D MN Mycobacterium Thymidine monophosphate kinase (MycB tmk) DMTOK1D MT DTT DMTOK1D MA Inhibitor DMTOK1D RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DMTOK1D RU https://pubmed.ncbi.nlm.nih.gov/10592235 DMTOK1D DI DMTOK1D DMTOK1D DN AMP-PNP DMTOK1D MI TT056SO DMTOK1D MN Stress-activated protein kinase JNK3 (JNK3) DMTOK1D MT DTT DMTOK1D MA Inhibitor DMTOK1D RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DMTOK1D RU https://pubmed.ncbi.nlm.nih.gov/10592235 DMXRIUT DI DMXRIUT DMXRIUT DN AMPSL DMXRIUT MI TT0HD6V DMXRIUT MN Leptin receptor (LEPR) DMXRIUT MT DTT DMXRIUT MA Modulator DMXRIUT RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1712). DMXRIUT RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1712 DM7WTKJ DI DM7WTKJ DM7WTKJ DN AMR-SIX-1 DM7WTKJ MI TTJS8PY DM7WTKJ MN 5-HT 6 receptor (HTR6) DM7WTKJ MT DTT DM7WTKJ MA Modulator DM7WTKJ RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 11). DM7WTKJ RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=11 DMO7EBX DI DMO7EBX DMO7EBX DN AMSH DMO7EBX MI TTD0CIQ DMO7EBX MN Melanocortin receptor 4 (MC4R) DMO7EBX MT DTT DMO7EBX MA Agonist DMO7EBX RN Designing drugs for the treatment of female sexual dysfunction. Drug Discov Today. 2007 Sep;12(17-18):757-66. DMO7EBX RU https://pubmed.ncbi.nlm.nih.gov/17826689 DM4OCAH DI DM4OCAH DM4OCAH DN AMTB DM4OCAH MI TTXDKTO DM4OCAH MN Long transient receptor potential channel 8 (TRPM8) DM4OCAH MT DTT DM4OCAH MA Blocker (channel blocker) DM4OCAH RN AMTB, a TRPM8 channel blocker: evidence in rats for activity in overactive bladder and painful bladder syndrome. Am J Physiol Renal Physiol. 2008 Sep;295(3):F803-10. DM4OCAH RU https://pubmed.ncbi.nlm.nih.gov/18562636 DMBAX3P DI DMBAX3P DMBAX3P DN amthamine DMBAX3P MI TTQHJ1K DMBAX3P MN Histamine H2 receptor (H2R) DMBAX3P MT DTT DMBAX3P MA Agonist DMBAX3P RN N(G)-acylated aminothiazolylpropylguanidines as potent and selective histamine H(2) receptor agonists. ChemMedChem. 2009 Feb;4(2):232-40. DMBAX3P RU https://pubmed.ncbi.nlm.nih.gov/19072936 DMGHXQE DI DMGHXQE DMGHXQE DN AMX-256 DMGHXQE MI TT1YWO5 DMGHXQE MN Glucagon-like peptide 2 receptor (GLP2R) DMGHXQE MT DTT DMGHXQE MA Modulator DMGHXQE RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 250). DMGHXQE RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=250 DMPSRZ0 DI DMPSRZ0 DMPSRZ0 DN AMXT-1501 DMPSRZ0 MI TTUMGNO DMPSRZ0 MN Ornithine decarboxylase (ODC1) DMPSRZ0 MT DTT DMPSRZ0 MA Inhibitor DMPSRZ0 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1276). DMPSRZ0 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1276 DM7SHQ1 DI DM7SHQ1 DM7SHQ1 DN Amythiamicin DM7SHQ1 MI TTG45NU DM7SHQ1 MN Plasmodium Elongation factor 1-alpha 1 (Malaria MEF-1) DM7SHQ1 MT DTT DM7SHQ1 MA Binder DM7SHQ1 RN The apicoplast as an antimalarial drug target. Drug Resist Updat. 2001 Jun;4(3):145-51. DM7SHQ1 RU https://pubmed.ncbi.nlm.nih.gov/11768328 DMRS0LA DI DMRS0LA DMRS0LA DN AN-207 DMRS0LA MI TT8R70G DMRS0LA MN Gonadotropin-releasing hormone receptor (GNRHR) DMRS0LA MT DTT DMRS0LA MA Inhibitor DMRS0LA RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 256). DMRS0LA RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=256 DMIY134 DI DMIY134 DMIY134 DN ANA-04 DMIY134 MI TT69OHW DMIY134 MN Interleukin 17 receptor (IL17R) DMIY134 MT DTT DMIY134 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2294). DMIY134 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2294 DM3DPSO DI DM3DPSO DM3DPSO DN ANA-5 DM3DPSO MI TTE4KHA DM3DPSO MN Amyloid beta A4 protein (APP) DM3DPSO MT DTT DM3DPSO MA Inhibitor DM3DPSO RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2402). DM3DPSO RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2402 DMAS5BI DI DMAS5BI DMAS5BI DN anacardic acid DMAS5BI MI TTVK7SB DMAS5BI MN Histone acetyltransferase KAT2B (KAT2B) DMAS5BI MT DTT DMAS5BI MA Inhibitor DMAS5BI RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2737). DMAS5BI RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2737 DMAS5BI DI DMAS5BI DMAS5BI DN anacardic acid DMAS5BI MI TTH4VJL DMAS5BI MN Histone acetyltransferase KAT6B (KAT6B) DMAS5BI MT DTT DMAS5BI MA Inhibitor DMAS5BI RN Small molecule modulators of histone acetyltransferase p300. J Biol Chem. 2003 May 23;278(21):19134-40. DMAS5BI RU https://pubmed.ncbi.nlm.nih.gov/12624111 DMMKGT4 DI DMMKGT4 DMMKGT4 DN analog 3 (Vlattas et al., 1996) DMMKGT4 MI TTE5J6X DMMKGT4 MN Diphosphomevalonate decarboxylase (MVD) DMMKGT4 MT DTT DMMKGT4 MA Inhibitor DMMKGT4 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 642). DMMKGT4 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=642 DMYW5JX DI DMYW5JX DMYW5JX DN ANALOG OF DYNORPHIN A DMYW5JX MI TT27RFC DMYW5JX MN Opioid receptor delta (OPRD1) DMYW5JX MT DTT DMYW5JX MA Inhibitor DMYW5JX RN Design and synthesis of highly potent and selective cyclic dynorphin A analogs. 2. New analogs. J Med Chem. 1993 Mar 19;36(6):750-7. DMYW5JX RU https://pubmed.ncbi.nlm.nih.gov/8096246 DM5JN3P DI DM5JN3P DM5JN3P DN ANALOGUE A DM5JN3P MI TTTSOUD DM5JN3P MN Candida Cytochrome P450 51 (Candi ERG11) DM5JN3P MT DTT DM5JN3P MA Inhibitor DM5JN3P RN Three-dimensional quantitative structure-activity relationship analysis of human CYP51 inhibitors. Drug Metab Dispos. 2007 Mar;35(3):493-500. DM5JN3P RU https://pubmed.ncbi.nlm.nih.gov/17194716 DMCKH3P DI DMCKH3P DMCKH3P DN Anandamide DMCKH3P MI TT6OEDT DMCKH3P MN Cannabinoid receptor 1 (CB1) DMCKH3P MT DTT DMCKH3P MA Agonist DMCKH3P RN Opioid receptor and NO/cGMP pathway as a mechanism of peripheral antinociceptive action of the cannabinoid receptor agonist anandamide. Life Sci. 2009 Aug 26;85(9-10):351-6. DMCKH3P RU https://pubmed.ncbi.nlm.nih.gov/19576231 DMX4P5A DI DMX4P5A DMX4P5A DN andarine DMX4P5A MI TTKPW01 DMX4P5A MN Androgen receptor messenger RNA (AR mRNA) DMX4P5A MT DTT DMX4P5A MA Agonist DMX4P5A RN Nonsteroidal selective androgen receptor modulators (SARMs): dissociating the anabolic and androgenic activities of the androgen receptor for therapeutic benefit. J Med Chem. 2009 Jun 25;52(12):3597-617. DMX4P5A RU https://pubmed.ncbi.nlm.nih.gov/19432422 DMHL0ID DI DMHL0ID DMHL0ID DN Andromustine DMHL0ID MI TTS64P2 DMHL0ID MN Androgen receptor (AR) DMHL0ID MT DTT DMHL0ID MA Modulator DMHL0ID RN The ChEMBL database in 2017. Nucleic Acids Res. 2017 Jan 4;45(D1):D945-D954. DMHL0ID RU https://www.ncbi.nlm.nih.gov/pubmed/27899562 DMPXF5I DI DMPXF5I DMPXF5I DN androstanol DMPXF5I MI TTRANFM DMPXF5I MN Orphan nuclear receptor NR1I3 (NR1I3) DMPXF5I MT DTT DMPXF5I MA Antagonist DMPXF5I RN Androstane metabolites bind to and deactivate the nuclear receptor CAR-beta. Nature. 1998 Oct 8;395(6702):612-5. DMPXF5I RU https://pubmed.ncbi.nlm.nih.gov/9783588 DMPL0BA DI DMPL0BA DMPL0BA DN ANDROSTENEDONE DMPL0BA MI TTSZLWK DMPL0BA MN Aromatase (CYP19A1) DMPL0BA MT DTT DMPL0BA MA Inhibitor DMPL0BA RN Effects of steroid D-ring modification on suicide inactivation and competitive inhibition of aromatase by analogues of androsta-1,4-diene-3,17-dione. J Med Chem. 1989 Mar;32(3):651-8. DMPL0BA RU https://pubmed.ncbi.nlm.nih.gov/2918514 DM7RXQ6 DI DM7RXQ6 DM7RXQ6 DN androstenol DM7RXQ6 MI TTRANFM DM7RXQ6 MN Orphan nuclear receptor NR1I3 (NR1I3) DM7RXQ6 MT DTT DM7RXQ6 MA Antagonist DM7RXQ6 RN Androstane metabolites bind to and deactivate the nuclear receptor CAR-beta. Nature. 1998 Oct 8;395(6702):612-5. DM7RXQ6 RU https://pubmed.ncbi.nlm.nih.gov/9783588 DMK1IMC DI DMK1IMC DMK1IMC DN ANG-2004 DMK1IMC MI TT0HD6V DMK1IMC MN Leptin receptor (LEPR) DMK1IMC MT DTT DMK1IMC MA Modulator DMK1IMC RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1712). DMK1IMC RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1712 DMDLVH5 DI DMDLVH5 DMDLVH5 DN ANG-2684 DMDLVH5 MI TTVDSZ0 DMDLVH5 MN Poly [ADP-ribose] polymerase 1 (PARP1) DMDLVH5 MT DTT DMDLVH5 MA Inhibitor DMDLVH5 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2771). DMDLVH5 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2771 DMQ2TNL DI DMQ2TNL DMQ2TNL DN ANG-2864 DMQ2TNL MI TTVDSZ0 DMQ2TNL MN Poly [ADP-ribose] polymerase 1 (PARP1) DMQ2TNL MT DTT DMQ2TNL MA Inhibitor DMQ2TNL RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2771). DMQ2TNL RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2771 DMVI93X DI DMVI93X DMVI93X DN ANG-3407 DMVI93X MI TTRA5BZ DMVI93X MN Steroid 17-alpha-monooxygenase (S17AH) DMVI93X MT DTT DMVI93X MA Inhibitor DMVI93X RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1361). DMVI93X RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1361 DM3KZ7P DI DM3KZ7P DM3KZ7P DN Angiostatin/paclitaxel/carboplatin DM3KZ7P MI TT63KYR DM3KZ7P MN Tubulin beta-1 chain (TUBB1) DM3KZ7P MT DTT DM3KZ7P MA Modulator DM3KZ7P RN Intravenous hydrophobic drug delivery: a porous particle formulation of paclitaxel (AI-850). Pharm Res. 2005 Mar;22(3):347-55. DM3KZ7P RU https://pubmed.ncbi.nlm.nih.gov/15835739 DMYK0Z9 DI DMYK0Z9 DMYK0Z9 DN angiotensin III DMYK0Z9 MI TT8DBY3 DMYK0Z9 MN Angiotensin II receptor type-1 (AGTR1) DMYK0Z9 MT DTT DMYK0Z9 MA Agonist DMYK0Z9 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 34). DMYK0Z9 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=34 DMYK0Z9 DI DMYK0Z9 DMYK0Z9 DN angiotensin III DMYK0Z9 MI TTQVOEI DMYK0Z9 MN Angiotensin II receptor type-2 (AGTR2) DMYK0Z9 MT DTT DMYK0Z9 MA Agonist DMYK0Z9 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 35). DMYK0Z9 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=35 DMR9OD1 DI DMR9OD1 DMR9OD1 DN Angiotensin IV DMR9OD1 MI TTPHMWB DMR9OD1 MN Aminopeptidase N (ANPEP) DMR9OD1 MT DTT DMR9OD1 MA Inhibitor DMR9OD1 RN Ligands to the (IRAP)/AT4 receptor encompassing a 4-hydroxydiphenylmethane scaffold replacing Tyr2. Bioorg Med Chem. 2008 Jul 15;16(14):6924-35. DMR9OD1 RU https://pubmed.ncbi.nlm.nih.gov/18556208 DMGRWA3 DI DMGRWA3 DMGRWA3 DN ANHYDRORYANIDINE DMGRWA3 MI TTU5CIX DMGRWA3 MN Ryanodine receptor 1 (RYR1) DMGRWA3 MT DTT DMGRWA3 MA Inhibitor DMGRWA3 RN Amino- and guanidinoacylryanodines: basic ryanodine esters with enhanced affinity for the sarcoplasmic reticulum Ca(2+)-release channel. J Med Chem. 1993 May 14;36(10):1319-23. DMGRWA3 RU https://pubmed.ncbi.nlm.nih.gov/8388466 DMJX1G9 DI DMJX1G9 DMJX1G9 DN ANIBAMINE DMJX1G9 MI TT2CEJG DMJX1G9 MN C-C chemokine receptor type 5 (CCR5) DMJX1G9 MT DTT DMJX1G9 MA Inhibitor DMJX1G9 RN Isolation and structure of antagonists of chemokine receptor (CCR5). J Nat Prod. 2004 Jun;67(6):1036-8. DMJX1G9 RU https://pubmed.ncbi.nlm.nih.gov/15217290 DMJCWXK DI DMJCWXK DMJCWXK DN Anidulafungin DMJCWXK MI TTV1095 DMJCWXK MN COVID-19 RNA-directed RNA polymerase (RdRp) DMJCWXK MT DTT DMJCWXK MA Inhibitor DMJCWXK RN Suramin, Penciclovir and Anidulafungin bind nsp12, which governs the RNA-dependent-RNA polymerase activity of SARS-CoV-2, with higher interaction energy than Remdesivir, indicating potential in the treatment of Covid-19 infection. April.21.2020. Doi: 10.31219/osf.io/urxwh DMJCWXK RU https://osf.io/urxwh DMLCAR9 DI DMLCAR9 DMLCAR9 DN Aniline DMLCAR9 MI DE4OGUF DMLCAR9 MN Cytochrome P450 102A1 (cyp102) DMLCAR9 MT DME DMLCAR9 MA Metabolism DMLCAR9 RN nan DMLCAR9 RU nan DMHA9S3 DI DMHA9S3 DMHA9S3 DN ANISOCOUMARIN H DMHA9S3 MI TTQW87Y DMHA9S3 MN Opioid receptor kappa (OPRK1) DMHA9S3 MT DTT DMHA9S3 MA Inhibitor DMHA9S3 RN Novel coumarin glycoside and phenethyl vanillate from Notopterygium forbesii and their binding affinities for opioid and dopamine receptors. Bioorg Med Chem. 2008 Mar 15;16(6):3218-23. DMHA9S3 RU https://pubmed.ncbi.nlm.nih.gov/18166466 DMZKC7S DI DMZKC7S DMZKC7S DN Ankinara DMZKC7S MI TTT0Q1F DMZKC7S MN Interleukin-10 (IL10) DMZKC7S MT DTT DMZKC7S MA Activator DMZKC7S RN Emerging drugs for the treatment of chronic obstructive pulmonary disease. Expert Opin Emerg Drugs. 2006 May;11(2):275-91. DMZKC7S RU https://pubmed.ncbi.nlm.nih.gov/16634702 DM0RUQ8 DI DM0RUQ8 DM0RUQ8 DN ANNULIN A DM0RUQ8 MI TTZJYKH DM0RUQ8 MN Indoleamine 2,3-dioxygenase 1 (IDO1) DM0RUQ8 MT DTT DM0RUQ8 MA Inhibitor DM0RUQ8 RN Indoleamine 2,3-dioxygenase inhibitors from the Northeastern Pacific Marine Hydroid Garveia annulata. J Nat Prod. 2006 Oct;69(10):1496-9. DM0RUQ8 RU https://pubmed.ncbi.nlm.nih.gov/17067170 DMDQXJ2 DI DMDQXJ2 DMDQXJ2 DN ANNULIN B DMDQXJ2 MI TTZJYKH DMDQXJ2 MN Indoleamine 2,3-dioxygenase 1 (IDO1) DMDQXJ2 MT DTT DMDQXJ2 MA Inhibitor DMDQXJ2 RN Indoleamine 2,3-dioxygenase inhibitors from the Northeastern Pacific Marine Hydroid Garveia annulata. J Nat Prod. 2006 Oct;69(10):1496-9. DMDQXJ2 RU https://pubmed.ncbi.nlm.nih.gov/17067170 DMTYQDO DI DMTYQDO DMTYQDO DN ANNULIN C DMTYQDO MI TTZJYKH DMTYQDO MN Indoleamine 2,3-dioxygenase 1 (IDO1) DMTYQDO MT DTT DMTYQDO MA Inhibitor DMTYQDO RN Indoleamine 2,3-dioxygenase inhibitors from the Northeastern Pacific Marine Hydroid Garveia annulata. J Nat Prod. 2006 Oct;69(10):1496-9. DMTYQDO RU https://pubmed.ncbi.nlm.nih.gov/17067170 DM6DYZ0 DI DM6DYZ0 DM6DYZ0 DN ANOLOBINE DM6DYZ0 MI TTEX248 DM6DYZ0 MN Dopamine D2 receptor (D2R) DM6DYZ0 MT DTT DM6DYZ0 MA Inhibitor DM6DYZ0 RN Advances in development of dopaminergic aporphinoids. J Med Chem. 2007 Jan 25;50(2):171-81. DM6DYZ0 RU https://pubmed.ncbi.nlm.nih.gov/17228858 DM6DYZ0 DI DM6DYZ0 DM6DYZ0 DN ANOLOBINE DM6DYZ0 MI TTVBI8W DM6DYZ0 MN Dopamine transporter (DAT) DM6DYZ0 MT DTT DM6DYZ0 MA Inhibitor DM6DYZ0 RN Effects of various isoquinoline alkaloids on in vitro 3H-dopamine uptake by rat striatal synaptosomes. J Nat Prod. 1995 Oct;58(10):1475-84. DM6DYZ0 RU https://pubmed.ncbi.nlm.nih.gov/8676127 DMM5PEV DI DMM5PEV DMM5PEV DN ANONAINE DMM5PEV MI TTEX248 DMM5PEV MN Dopamine D2 receptor (D2R) DMM5PEV MT DTT DMM5PEV MA Inhibitor DMM5PEV RN Advances in development of dopaminergic aporphinoids. J Med Chem. 2007 Jan 25;50(2):171-81. DMM5PEV RU https://pubmed.ncbi.nlm.nih.gov/17228858 DMM5PEV DI DMM5PEV DMM5PEV DN ANONAINE DMM5PEV MI TTVBI8W DMM5PEV MN Dopamine transporter (DAT) DMM5PEV MT DTT DMM5PEV MA Inhibitor DMM5PEV RN Effects of various isoquinoline alkaloids on in vitro 3H-dopamine uptake by rat striatal synaptosomes. J Nat Prod. 1995 Oct;58(10):1475-84. DMM5PEV RU https://pubmed.ncbi.nlm.nih.gov/8676127 DMGDZ6Q DI DMGDZ6Q DMGDZ6Q DN Antanal 1 DMGDZ6Q MI TT27RFC DMGDZ6Q MN Opioid receptor delta (OPRD1) DMGDZ6Q MT DTT DMGDZ6Q MA Inhibitor DMGDZ6Q RN Novel opioid peptide derived antagonists containing (2S)-2-methyl-3-(2,6-dimethyl-4-carbamoylphenyl)propanoic acid [(2S)-Mdcp]. J Med Chem. 2008 Sep 25;51(18):5866-70. DMGDZ6Q RU https://pubmed.ncbi.nlm.nih.gov/18800771 DMGDZ6Q DI DMGDZ6Q DMGDZ6Q DN Antanal 1 DMGDZ6Q MI TTKWM86 DMGDZ6Q MN Opioid receptor mu (MOP) DMGDZ6Q MT DTT DMGDZ6Q MA Inhibitor DMGDZ6Q RN Novel opioid peptide derived antagonists containing (2S)-2-methyl-3-(2,6-dimethyl-4-carbamoylphenyl)propanoic acid [(2S)-Mdcp]. J Med Chem. 2008 Sep 25;51(18):5866-70. DMGDZ6Q RU https://pubmed.ncbi.nlm.nih.gov/18800771 DMZSUHY DI DMZSUHY DMZSUHY DN Antanal 2 DMZSUHY MI TT27RFC DMZSUHY MN Opioid receptor delta (OPRD1) DMZSUHY MT DTT DMZSUHY MA Inhibitor DMZSUHY RN Novel opioid peptide derived antagonists containing (2S)-2-methyl-3-(2,6-dimethyl-4-carbamoylphenyl)propanoic acid [(2S)-Mdcp]. J Med Chem. 2008 Sep 25;51(18):5866-70. DMZSUHY RU https://pubmed.ncbi.nlm.nih.gov/18800771 DMZSUHY DI DMZSUHY DMZSUHY DN Antanal 2 DMZSUHY MI TTKWM86 DMZSUHY MN Opioid receptor mu (MOP) DMZSUHY MT DTT DMZSUHY MA Inhibitor DMZSUHY RN Novel opioid peptide derived antagonists containing (2S)-2-methyl-3-(2,6-dimethyl-4-carbamoylphenyl)propanoic acid [(2S)-Mdcp]. J Med Chem. 2008 Sep 25;51(18):5866-70. DMZSUHY RU https://pubmed.ncbi.nlm.nih.gov/18800771 DMA7LUR DI DMA7LUR DMA7LUR DN ANTAQ DMA7LUR MI TT371QC DMA7LUR MN Puromycin-sensitive aminopeptidase (NPEPPS) DMA7LUR MT DTT DMA7LUR MA Inhibitor DMA7LUR RN Fluorescent bioprobes for visualization of puromycin-sensitive aminopeptidase in living cells. Bioorg Med Chem Lett. 2003 Jan 6;13(1):83-6. DMA7LUR RU https://pubmed.ncbi.nlm.nih.gov/12467622 DM7TOGW DI DM7TOGW DM7TOGW DN antarelix DM7TOGW MI TT8R70G DM7TOGW MN Gonadotropin-releasing hormone receptor (GNRHR) DM7TOGW MT DTT DM7TOGW MA Antagonist DM7TOGW RN Characterization of gonadotropin-releasing hormone analogs based on a sensitive cellular luciferase reporter gene assay. Anal Biochem. 1997 Aug 15;251(1):17-23. DM7TOGW RU https://pubmed.ncbi.nlm.nih.gov/9300077 DMRQVW9 DI DMRQVW9 DMRQVW9 DN Anthoptilide C DMRQVW9 MI TTK25J1 DMRQVW9 MN Adenosine A1 receptor (ADORA1) DMRQVW9 MT DTT DMRQVW9 MA Inhibitor DMRQVW9 RN Anthoptilides A-E, new Briarane diterpenes from the Australian sea pen Anthoptilum cf. kukenthali. J Nat Prod. 2000 Mar;63(3):318-21. DMRQVW9 RU https://pubmed.ncbi.nlm.nih.gov/10757710 DMGEMQX DI DMGEMQX DMGEMQX DN Anthracen-10-yl(10H-phenothiazin-10-yl)methanone DMGEMQX MI TTEB0GD DMGEMQX MN Cholinesterase (BCHE) DMGEMQX MT DTT DMGEMQX MA Inhibitor DMGEMQX RN Selective reversible inhibition of human butyrylcholinesterase by aryl amide derivatives of phenothiazine. Bioorg Med Chem. 2007 Oct 1;15(19):6367-78. DMGEMQX RU https://pubmed.ncbi.nlm.nih.gov/17681768 DMRC3OU DI DMRC3OU DMRC3OU DN Anthracene-2-carboxylic acid hydroxyamide DMRC3OU MI TT2J34L DMRC3OU MN Arachidonate 5-lipoxygenase (5-LOX) DMRC3OU MT DTT DMRC3OU MA Inhibitor DMRC3OU RN Hydroxamic acid inhibitors of 5-lipoxygenase: quantitative structure-activity relationships. J Med Chem. 1990 Mar;33(3):992-8. DMRC3OU RU https://pubmed.ncbi.nlm.nih.gov/2308149 DMN1YFU DI DMN1YFU DMN1YFU DN Anthraflavic acid DMN1YFU MI DEYGVN4 DMN1YFU MN UDP-glucuronosyltransferase 1A1 (UGT1A1) DMN1YFU MT DME DMN1YFU MA Metabolism DMN1YFU RN Differential and special properties of the major human UGT1-encoded gastrointestinal UDP-glucuronosyltransferases enhance potential to control chemical uptake. J Biol Chem. 2004 Jan 9;279(2):1429-41. DMN1YFU RU https://www.ncbi.nlm.nih.gov/pubmed/?term=14557274 DMN1YFU DI DMN1YFU DMN1YFU DN Anthraflavic acid DMN1YFU MI DEZO4N3 DMN1YFU MN UDP-glucuronosyltransferase 1A7 (UGT1A7) DMN1YFU MT DME DMN1YFU MA Metabolism DMN1YFU RN Differential and special properties of the major human UGT1-encoded gastrointestinal UDP-glucuronosyltransferases enhance potential to control chemical uptake. J Biol Chem. 2004 Jan 9;279(2):1429-41. DMN1YFU RU https://www.ncbi.nlm.nih.gov/pubmed/?term=14557274 DMN1YFU DI DMN1YFU DMN1YFU DN Anthraflavic acid DMN1YFU MI DE2GB8N DMN1YFU MN UDP-glucuronosyltransferase 1A8 (UGT1A8) DMN1YFU MT DME DMN1YFU MA Metabolism DMN1YFU RN Differential and special properties of the major human UGT1-encoded gastrointestinal UDP-glucuronosyltransferases enhance potential to control chemical uptake. J Biol Chem. 2004 Jan 9;279(2):1429-41. DMN1YFU RU https://www.ncbi.nlm.nih.gov/pubmed/?term=14557274 DMN1YFU DI DMN1YFU DMN1YFU DN Anthraflavic acid DMN1YFU MI DE85D2P DMN1YFU MN UDP-glucuronosyltransferase 1A9 (UGT1A9) DMN1YFU MT DME DMN1YFU MA Metabolism DMN1YFU RN Differential and special properties of the major human UGT1-encoded gastrointestinal UDP-glucuronosyltransferases enhance potential to control chemical uptake. J Biol Chem. 2004 Jan 9;279(2):1429-41. DMN1YFU RU https://www.ncbi.nlm.nih.gov/pubmed/?term=14557274 DMNEGHJ DI DMNEGHJ DMNEGHJ DN Anthramycin DMNEGHJ MI TTJP4SM DMNEGHJ MN Bacterial Penicillin binding protein (Bact PBP) DMNEGHJ MT DTT DMNEGHJ RN Crystal structure of a covalent DNA-drug adduct: anthramycin bound to C-C-A-A-C-G-T-T-G-G and a molecular explanation of specificity. Biochemistry. 1994 Nov 22;33(46):13593-610. DMNEGHJ RU https://pubmed.ncbi.nlm.nih.gov/7947769 DM29I0Y DI DM29I0Y DM29I0Y DN ANTHRAQUINONE DM29I0Y MI TTR0SWN DM29I0Y MN M-phase inducer phosphatase 2 (MPIP2) DM29I0Y MT DTT DM29I0Y MA Inhibitor DM29I0Y RN Bioactivities of simplified adociaquinone B and naphthoquinone derivatives against Cdc25B, MKP-1, and MKP-3 phosphatases. Bioorg Med Chem. 2009 Mar 15;17(6):2276-81. DM29I0Y RU https://pubmed.ncbi.nlm.nih.gov/19028102 DMWZ093 DI DMWZ093 DMWZ093 DN ANTHRONE DMWZ093 MI TT2J34L DMWZ093 MN Arachidonate 5-lipoxygenase (5-LOX) DMWZ093 MT DTT DMWZ093 MA Inhibitor DMWZ093 RN Simple analogues of anthralin: unusual specificity of structure and antiproliferative activity. J Med Chem. 1997 Nov 7;40(23):3773-80. DMWZ093 RU https://pubmed.ncbi.nlm.nih.gov/9371243 DM3IOR0 DI DM3IOR0 DM3IOR0 DN anti-BrP-LPA DM3IOR0 MI TTQ6S1K DM3IOR0 MN Lysophosphatidic acid receptor 1 (LPAR1) DM3IOR0 MT DTT DM3IOR0 MA Antagonist DM3IOR0 RN Dual activity lysophosphatidic acid receptor pan-antagonist/autotaxin inhibitor reduces breast cancer cell migration in vitro and causes tumor regression in vivo. Cancer Res. 2009 Jul 1;69(13):5441-9. DM3IOR0 RU https://pubmed.ncbi.nlm.nih.gov/19509223 DMQJ3ZL DI DMQJ3ZL DMQJ3ZL DN Anticalin DMQJ3ZL MI TTE4KHA DMQJ3ZL MN Amyloid beta A4 protein (APP) DMQJ3ZL MT DTT DMQJ3ZL MA Inhibitor DMQJ3ZL RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2402). DMQJ3ZL RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2402 DMEHRKA DI DMEHRKA DMEHRKA DN Anti-CD20 engineered toxin bodies DMEHRKA MI TTUE541 DMEHRKA MN Leukocyte surface antigen Leu-16 (CD20) DMEHRKA MT DTT DMEHRKA MA Modulator DMEHRKA RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2628). DMEHRKA RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2628 DMCYOPR DI DMCYOPR DMCYOPR DN Anti-CD-20 mab DMCYOPR MI TTUE541 DMCYOPR MN Leukocyte surface antigen Leu-16 (CD20) DMCYOPR MT DTT DMCYOPR MA Inhibitor DMCYOPR RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2628). DMCYOPR RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2628 DM8QIB2 DI DM8QIB2 DM8QIB2 DN Anti-CD22/CD19 mab-toxin conjugate DM8QIB2 MI TTM6QSK DM8QIB2 MN B-cell receptor CD22 (CD22) DM8QIB2 MT DTT DM8QIB2 MA Modulator DM8QIB2 RN Immunotoxins against CD19 and CD22 are effective in killing precursor-B acute lymphoblastic leukemia cells in vitro. Leukemia. 2000 May;14(5):853-8. DM8QIB2 RU https://pubmed.ncbi.nlm.nih.gov/10803517 DM8QIB2 DI DM8QIB2 DM8QIB2 DN Anti-CD22/CD19 mab-toxin conjugate DM8QIB2 MI TTW640A DM8QIB2 MN B-lymphocyte surface antigen B4 (CD19) DM8QIB2 MT DTT DM8QIB2 MA Modulator DM8QIB2 RN Immunotoxins against CD19 and CD22 are effective in killing precursor-B acute lymphoblastic leukemia cells in vitro. Leukemia. 2000 May;14(5):853-8. DM8QIB2 RU https://pubmed.ncbi.nlm.nih.gov/10803517 DM5BH7J DI DM5BH7J DM5BH7J DN Anti-CD28 DM5BH7J MI TTQ13FT DM5BH7J MN T-cell-specific surface glycoprotein CD28 (CD28) DM5BH7J MT DTT DM5BH7J RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2863). DM5BH7J RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2863 DMGZM6V DI DMGZM6V DMGZM6V DN Anti-CD40-XTEN DMGZM6V MI TTN6Y9A DMGZM6V MN CD40L receptor (CD40) DMGZM6V MT DTT DMGZM6V MA Antagonist DMGZM6V RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1874). DMGZM6V RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1874 DM2X1SG DI DM2X1SG DM2X1SG DN Anti-cMET mab DM2X1SG MI TTNDSF4 DM2X1SG MN Proto-oncogene c-Met (MET) DM2X1SG MT DTT DM2X1SG MA Inhibitor DM2X1SG RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1815). DM2X1SG RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1815 DMG7PC0 DI DMG7PC0 DMG7PC0 DN Anti-D DMG7PC0 MI TTEX248 DMG7PC0 MN Dopamine D2 receptor (D2R) DMG7PC0 MT DTT DMG7PC0 MA Antagonist DMG7PC0 RN Emerging drugs for idiopathic thrombocytopenic purpura in adults. Expert Opin Emerg Drugs. 2008 Jun;13(2):237-54. DMG7PC0 RU https://pubmed.ncbi.nlm.nih.gov/18537519 DMWLMV2 DI DMWLMV2 DMWLMV2 DN Anti-EGFR humanized mabs DMWLMV2 MI TTGKNB4 DMWLMV2 MN Epidermal growth factor receptor (EGFR) DMWLMV2 MT DTT DMWLMV2 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1797). DMWLMV2 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1797 DMW85FP DI DMW85FP DMW85FP DN Anti-EGFR mab DMW85FP MI TTGKNB4 DMW85FP MN Epidermal growth factor receptor (EGFR) DMW85FP MT DTT DMW85FP RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1797). DMW85FP RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1797 DMXWHDC DI DMXWHDC DMXWHDC DN Anti-Fas mabs DMXWHDC MI TT7AOUD DMXWHDC MN Fatty acid synthase (FASN) DMXWHDC MT DTT DMXWHDC RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2608). DMXWHDC RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2608 DMP5VZQ DI DMP5VZQ DMP5VZQ DN Anti-FGFR1 mab program DMP5VZQ MI TTRLW2X DMP5VZQ MN Fibroblast growth factor receptor 1 (FGFR1) DMP5VZQ MT DTT DMP5VZQ RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1808). DMP5VZQ RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1808 DMMQ3WX DI DMMQ3WX DMMQ3WX DN Anti-FGFR2 humanized mab DMMQ3WX MI TTGJVQM DMMQ3WX MN Fibroblast growth factor receptor 2 (FGFR2) DMMQ3WX MT DTT DMMQ3WX RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1809). DMMQ3WX RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1809 DM4HKC8 DI DM4HKC8 DM4HKC8 DN Anti-GnRH Spiegelmer DM4HKC8 MI TT0ID4A DM4HKC8 MN Leutinizing-hormone-releasing hormone (GNRH1) DM4HKC8 MT DTT DM4HKC8 MA Inhibitor DM4HKC8 RN In vivo properties of an anti-GnRH Spiegelmer: an example of an oligonucleotide-based therapeutic substance class. Proc Natl Acad Sci U S A. 2002 Jun 25;99(13):8898-902. DM4HKC8 RU https://pubmed.ncbi.nlm.nih.gov/12070349 DMVF2YH DI DMVF2YH DMVF2YH DN Antileukoprotease (ALP) DMVF2YH MI TTE6GTB DMVF2YH MN Kallikrein-7 (KLK7) DMVF2YH MT DTT DMVF2YH MA Inhibitor DMVF2YH RN Expression of the protease inhibitor antileukoprotease and the serine protease stratum corneum chymotryptic enzyme (SCCE) is coordinated in ovarian tumors. Int J Gynecol Cancer. 2001 Nov-Dec;11(6):454-61. DMVF2YH RU https://pubmed.ncbi.nlm.nih.gov/11906548 DMO41UZ DI DMO41UZ DMO41UZ DN Anti-miR-191 modified oligonucleotide DMO41UZ MI TT3ULBR DMO41UZ MN microRNA hsa-miR-191 (MIR191) DMO41UZ MT DTT DMO41UZ RN hsa-miR-191 is a candidate oncogene target for hepatocellular carcinoma therapy. Cancer Res. 2010 Oct 15;70(20):8077-87. DMO41UZ RU https://pubmed.ncbi.nlm.nih.gov/20924108 DM2EMCW DI DM2EMCW DM2EMCW DN Antimycin A DM2EMCW MI TT3PQ2Y DM2EMCW MN Plasmodium Dihydroorotate dehydrogenase (Malaria DHOdehase) DM2EMCW MT DTT DM2EMCW MA Inhibitor DM2EMCW RN Effects of atovaquone and other inhibitors on Pneumocystis carinii dihydroorotate dehydrogenase. Antimicrob Agents Chemother. 1995 Feb;39(2):325-8. DM2EMCW RU https://pubmed.ncbi.nlm.nih.gov/7726490 DMUESP8 DI DMUESP8 DMUESP8 DN ANTIOQUINE DMUESP8 MI TTVBI8W DMUESP8 MN Dopamine transporter (DAT) DMUESP8 MT DTT DMUESP8 MA Inhibitor DMUESP8 RN Effects of various isoquinoline alkaloids on in vitro 3H-dopamine uptake by rat striatal synaptosomes. J Nat Prod. 1995 Oct;58(10):1475-84. DMUESP8 RU https://pubmed.ncbi.nlm.nih.gov/8676127 DM9THZE DI DM9THZE DM9THZE DN Antiproliferative Agent A771726 DM9THZE MI TT3PQ2Y DM9THZE MN Plasmodium Dihydroorotate dehydrogenase (Malaria DHOdehase) DM9THZE MT DTT DM9THZE MA Inhibitor DM9THZE RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DM9THZE RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMO21T7 DI DMO21T7 DMO21T7 DN Anti-PSA mabs DMO21T7 MI TTS78AZ DMO21T7 MN Prostate specific antigen (KLK3) DMO21T7 MT DTT DMO21T7 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2373). DMO21T7 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2373 DMXACM2 DI DMXACM2 DMXACM2 DN Anti-RON receptor mabs DMXACM2 MI TTBQ3OC DMXACM2 MN Macrophage-stimulating protein receptor (RON) DMXACM2 MT DTT DMXACM2 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1816). DMXACM2 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1816 DMN76A4 DI DMN76A4 DMN76A4 DN Anti-TLR3 mabs DMN76A4 MI TTD24Y0 DMN76A4 MN Toll-like receptor 3 (TLR3) DMN76A4 MT DTT DMN76A4 MA Modulator DMN76A4 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1753). DMN76A4 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1753 DMYKTF6 DI DMYKTF6 DMYKTF6 DN Anti-TNF human mabs DMYKTF6 MI TTG043C DMYKTF6 MN Tumor necrosis factor receptor type I (TNF-R1) DMYKTF6 MT DTT DMYKTF6 RN Secretion of a TNFR:Fc fusion protein following pulmonary administration of pseudotyped adeno-associated virus vectors. J Virol. 2004 Nov;78(22):12355-65. DMYKTF6 RU https://pubmed.ncbi.nlm.nih.gov/15507622 DMAJ6TC DI DMAJ6TC DMAJ6TC DN Anti-VEGFR 3 mab DMAJ6TC MI TTDCBX5 DMAJ6TC MN Vascular endothelial growth factor receptor 3 (FLT-4) DMAJ6TC MT DTT DMAJ6TC MA Inhibitor DMAJ6TC RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1814). DMAJ6TC RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1814 DML1PV3 DI DML1PV3 DML1PV3 DN Aom-0763 DML1PV3 MI TT7RJY8 DML1PV3 MN Xanthine dehydrogenase/oxidase (XDH) DML1PV3 MT DTT DML1PV3 MA Inhibitor DML1PV3 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2646). DML1PV3 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2646 DMT4I2W DI DMT4I2W DMT4I2W DN Aom-0890 DMT4I2W MI TTJ0IQB DMT4I2W MN Phosphodiesterase 5A (PDE5A) DMT4I2W MT DTT DMT4I2W MA Inhibitor DMT4I2W RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1304). DMT4I2W RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1304 DMHR3ZG DI DMHR3ZG DMHR3ZG DN AP-101 DMHR3ZG MI TT9VGXW DMHR3ZG MN Angiopoietin 1 receptor (TEK) DMHR3ZG MT DTT DMHR3ZG MA Modulator DMHR3ZG RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1842). DMHR3ZG RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1842 DMRZMKT DI DMRZMKT DMRZMKT DN AP-1189 DMRZMKT MI TT0MV2T DMRZMKT MN Melanocortin receptor 1 (MC1R) DMRZMKT MT DTT DMRZMKT MA Modulator DMRZMKT RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 282). DMRZMKT RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=282 DMCNG74 DI DMCNG74 DMCNG74 DN AP-21967 DMCNG74 MI TTCJG29 DMCNG74 MN Serine/threonine-protein kinase mTOR (mTOR) DMCNG74 MT DTT DMCNG74 MA Inhibitor DMCNG74 RN The rapamycin-binding domain of the protein kinase mammalian target of rapamycin is a destabilizing domain. J Biol Chem. 2007 May 4;282(18):13395-401. DMCNG74 RU https://pubmed.ncbi.nlm.nih.gov/17350953 DMQWIEL DI DMQWIEL DMQWIEL DN AP-2238 DMQWIEL MI TT1RS9F DMQWIEL MN Acetylcholinesterase (AChE) DMQWIEL MT DTT DMQWIEL MA Inhibitor DMQWIEL RN Targeting Alzheimer's disease: Novel indanone hybrids bearing a pharmacophoric fragment of AP2238. Bioorg Med Chem. 2010 Mar 1;18(5):1749-60. DMQWIEL RU https://pubmed.ncbi.nlm.nih.gov/20171894 DMRYL9X DI DMRYL9X DMRYL9X DN AP-2243 DMRYL9X MI TT1RS9F DMRYL9X MN Acetylcholinesterase (AChE) DMRYL9X MT DTT DMRYL9X MA Inhibitor DMRYL9X RN Multi-target-directed coumarin derivatives: hAChE and BACE1 inhibitors as potential anti-Alzheimer compounds. Bioorg Med Chem Lett. 2008 Jan 1;18(1):423-6. DMRYL9X RU https://pubmed.ncbi.nlm.nih.gov/17998161 DMRYL9X DI DMRYL9X DMRYL9X DN AP-2243 DMRYL9X MI TT8JRS7 DMRYL9X MN Beta-secretase (BACE) DMRYL9X MT DTT DMRYL9X MA Inhibitor DMRYL9X RN Multi-target-directed coumarin derivatives: hAChE and BACE1 inhibitors as potential anti-Alzheimer compounds. Bioorg Med Chem Lett. 2008 Jan 1;18(1):423-6. DMRYL9X RU https://pubmed.ncbi.nlm.nih.gov/17998161 DMVT6Y3 DI DMVT6Y3 DMVT6Y3 DN AP-24163 DMVT6Y3 MI TTIV39N DMVT6Y3 MN Fusion protein Bcr-Abl T315I mutant (Bcr-Abl T315I) DMVT6Y3 MT DTT DMVT6Y3 MA Inhibitor DMVT6Y3 RN Discovery of 3-[2-(imidazo[1,2-b]pyridazin-3-yl)ethynyl]-4-methyl-N-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzamide (AP2453... J Med Chem. 2010 Jun 24;53(12):4701-19. DMVT6Y3 RU https://pubmed.ncbi.nlm.nih.gov/20513156 DMVT6Y3 DI DMVT6Y3 DMVT6Y3 DN AP-24163 DMVT6Y3 MI TT6PKBN DMVT6Y3 MN Proto-oncogene c-Src (SRC) DMVT6Y3 MT DTT DMVT6Y3 MA Inhibitor DMVT6Y3 RN 9-(Arenethenyl)purines as dual Src/Abl kinase inhibitors targeting the inactive conformation: design, synthesis, and biological evaluation. J Med Chem. 2009 Aug 13;52(15):4743-56. DMVT6Y3 RU https://pubmed.ncbi.nlm.nih.gov/19572547 DMGTEXD DI DMGTEXD DMGTEXD DN AP-24226 DMGTEXD MI TT6PKBN DMGTEXD MN Proto-oncogene c-Src (SRC) DMGTEXD MT DTT DMGTEXD MA Inhibitor DMGTEXD RN 9-(Arenethenyl)purines as dual Src/Abl kinase inhibitors targeting the inactive conformation: design, synthesis, and biological evaluation. J Med Chem. 2009 Aug 13;52(15):4743-56. DMGTEXD RU https://pubmed.ncbi.nlm.nih.gov/19572547 DMGTEXD DI DMGTEXD DMGTEXD DN AP-24226 DMGTEXD MI TT3PJMV DMGTEXD MN Tyrosine-protein kinase ABL1 (ABL) DMGTEXD MT DTT DMGTEXD MA Inhibitor DMGTEXD RN Discovery of 3-[2-(imidazo[1,2-b]pyridazin-3-yl)ethynyl]-4-methyl-N-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzamide (AP2453... J Med Chem. 2010 Jun 24;53(12):4701-19. DMGTEXD RU https://pubmed.ncbi.nlm.nih.gov/20513156 DMBU942 DI DMBU942 DMBU942 DN AP-7 DMBU942 MI TTLD29N DMBU942 MN Glutamate receptor ionotropic NMDA 1 (NMDAR1) DMBU942 MT DTT DMBU942 MA Inhibitor DMBU942 RN Bioisosteric replacement of the alpha-amino carboxylic acid functionality in 2-amino-5-phosphonopentanoic acid yields unique 3,4-diamino-3-cyclobut... J Med Chem. 1992 Dec 11;35(25):4720-6. DMBU942 RU https://pubmed.ncbi.nlm.nih.gov/1361582 DMBU942 DI DMBU942 DMBU942 DN AP-7 DMBU942 MI TTKJEMQ DMBU942 MN Glutamate receptor ionotropic NMDA 2A (NMDAR2A) DMBU942 MT DTT DMBU942 MA Inhibitor DMBU942 RN Bioisosteric replacement of the alpha-amino carboxylic acid functionality in 2-amino-5-phosphonopentanoic acid yields unique 3,4-diamino-3-cyclobut... J Med Chem. 1992 Dec 11;35(25):4720-6. DMBU942 RU https://pubmed.ncbi.nlm.nih.gov/1361582 DMBU942 DI DMBU942 DMBU942 DN AP-7 DMBU942 MI TTN9D8E DMBU942 MN Glutamate receptor ionotropic NMDA 2B (NMDAR2B) DMBU942 MT DTT DMBU942 MA Inhibitor DMBU942 RN Bioisosteric replacement of the alpha-amino carboxylic acid functionality in 2-amino-5-phosphonopentanoic acid yields unique 3,4-diamino-3-cyclobut... J Med Chem. 1992 Dec 11;35(25):4720-6. DMBU942 RU https://pubmed.ncbi.nlm.nih.gov/1361582 DMILA4P DI DMILA4P DMILA4P DN AP811 DMILA4P MI TTWVLS6 DMILA4P MN Natriuretic peptide receptor (NPR3) DMILA4P MT DTT DMILA4P MA Antagonist DMILA4P RN The discovery of non-basic atrial natriuretic peptide clearance receptor antagonists. Part 1. Bioorg Med Chem Lett. 2000 Sep 4;10(17):1949-52. DMILA4P RU https://pubmed.ncbi.nlm.nih.gov/10987424 DMVG3K1 DI DMVG3K1 DMVG3K1 DN APA DMVG3K1 MI TTUMGNO DMVG3K1 MN Ornithine decarboxylase (ODC1) DMVG3K1 MT DTT DMVG3K1 MA Inhibitor DMVG3K1 RN 2-substituted 3-(aminooxy)propanamines as inhibitors of ornithine decarboxylase: synthesis and biological activity. J Med Chem. 1992 Apr 17;35(8):1339-44. DMVG3K1 RU https://pubmed.ncbi.nlm.nih.gov/1573631 DMYNBK5 DI DMYNBK5 DMYNBK5 DN Apamin DMYNBK5 MI TT9R6BE DMYNBK5 MN Calcium-activated potassium channel KCa2.1 (KCNN1) DMYNBK5 MT DTT DMYNBK5 MA Blocker (channel blocker) DMYNBK5 RN Pharmacological characterization of small-conductance Ca(2+)-activated K(+) channels stably expressed in HEK 293 cells. Br J Pharmacol. 2000 Mar;129(5):991-9. DMYNBK5 RU https://pubmed.ncbi.nlm.nih.gov/10696100 DMYNBK5 DI DMYNBK5 DMYNBK5 DN Apamin DMYNBK5 MI TT2T5M0 DMYNBK5 MN Calcium-activated potassium channel KCa2.2 (KCNN2) DMYNBK5 MT DTT DMYNBK5 MA Blocker (channel blocker) DMYNBK5 RN SK2 encodes the apamin-sensitive Ca(2+)-activated K(+) channels in the human leukemic T cell line, Jurkat. FEBS Lett. 2000 Mar 10;469(2-3):196-202. DMYNBK5 RU https://pubmed.ncbi.nlm.nih.gov/10713270 DMYNBK5 DI DMYNBK5 DMYNBK5 DN Apamin DMYNBK5 MI TT9JH25 DMYNBK5 MN Calcium-activated potassium channel KCa2.3 (KCNN3) DMYNBK5 MT DTT DMYNBK5 MA Blocker (channel blocker) DMYNBK5 RN SK3 is an important component of K(+) channels mediating the afterhyperpolarization in cultured rat SCG neurones. J Physiol. 2001 Sep 1;535(Pt 2):323-34. DMYNBK5 RU https://pubmed.ncbi.nlm.nih.gov/11533126 DMNIEHV DI DMNIEHV DMNIEHV DN APC-300 DMNIEHV MI TTW2R9X DMNIEHV MN GTPase NRas (NRAS) DMNIEHV MT DTT DMNIEHV MA Inhibitor DMNIEHV RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2823). DMNIEHV RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2823 DMT9Z5A DI DMT9Z5A DMT9Z5A DN AP-Cav DMT9Z5A MI TTCM4B3 DMT9Z5A MN Nitric-oxide synthase endothelial (NOS3) DMT9Z5A MT DTT DMT9Z5A MA Inhibitor DMT9Z5A RN Endothelial nitric oxide synthase: the Cinderella of inflammation Trends Pharmacol Sci. 2003 Feb;24(2):91-5. DMT9Z5A RU https://pubmed.ncbi.nlm.nih.gov/12559774 DMNQ9M1 DI DMNQ9M1 DMNQ9M1 DN APCK-110 DMNQ9M1 MI TTX41N9 DMNQ9M1 MN Tyrosine-protein kinase Kit (KIT) DMNQ9M1 MT DTT DMNQ9M1 MA Inhibitor DMNQ9M1 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1805). DMNQ9M1 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1805 DM2CKUZ DI DM2CKUZ DM2CKUZ DN apelin-13 DM2CKUZ MI TTJ8E43 DM2CKUZ MN Apelin receptor (APLNR) DM2CKUZ MT DTT DM2CKUZ MA Agonist DM2CKUZ RN Structural and functional study of the apelin-13 peptide, an endogenous ligand of the HIV-1 coreceptor, APJ. Biochemistry. 2003 Sep 2;42(34):10163-8. DM2CKUZ RU https://pubmed.ncbi.nlm.nih.gov/12939143 DM0JW2V DI DM0JW2V DM0JW2V DN APETX2 DM0JW2V MI TTLGDIS DM0JW2V MN Acid-sensing ion channel 3 (ASIC3) DM0JW2V MT DTT DM0JW2V MA Blocker DM0JW2V RN Challenges in analgesic drug development. Clin Pharmacol Ther. 2009 Oct;86(4):447-50. DM0JW2V RU https://pubmed.ncbi.nlm.nih.gov/19675542 DMR93WE DI DMR93WE DMR93WE DN APG-103 DMR93WE MI TTF0RCZ DMR93WE MN Apoptosis mediating surface antigen FAS (FAS) DMR93WE MT DTT DMR93WE MA Inhibitor DMR93WE RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1875). DMR93WE RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1875 DM0BVJN DI DM0BVJN DM0BVJN DN APG-201 DM0BVJN MI TTDWHC3 DM0BVJN MN Interleukin 4 receptor alpha (IL4R) DM0BVJN MT DTT DM0BVJN MA Antagonist DM0BVJN RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1697). DM0BVJN RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1697 DMBSDTR DI DMBSDTR DMBSDTR DN APG-2305 DMBSDTR MI TT6H4QR DMBSDTR MN Interleukin 23 receptor (IL23R) DMBSDTR MT DTT DMBSDTR MA Inhibitor DMBSDTR RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2293). DMBSDTR RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2293 DMYGKW7 DI DMYGKW7 DMYGKW7 DN APH-0911 DMYGKW7 MI TTYFKSZ DMYGKW7 MN Tubulin beta (TUBB) DMYGKW7 MT DTT DMYGKW7 MA Modulator DMYGKW7 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2640). DMYGKW7 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2640 DM83WVF DI DM83WVF DM83WVF DN Apicidin DM83WVF MI TTBH0VX DM83WVF MN Histone deacetylase (HDAC) DM83WVF MT DTT DM83WVF MA Inhibitor DM83WVF RN Histone deacetylase inhibitors in cancer therapy: latest developments, trends and medicinal chemistry perspective. Anticancer Agents Med Chem. 2007 Sep;7(5):576-92. DM83WVF RU https://pubmed.ncbi.nlm.nih.gov/17896917 DMI3491 DI DMI3491 DMI3491 DN Apigenin DMI3491 MI TTFBNVI DMI3491 MN Aldose reductase (AKR1B1) DMI3491 MT DTT DMI3491 MA Inhibitor DMI3491 RN Erigeroflavanone, a flavanone derivative from the flowers of Erigeron annuus with protein glycation and aldose reductase inhibitory activity. J Nat Prod. 2008 Apr;71(4):713-5. DMI3491 RU https://pubmed.ncbi.nlm.nih.gov/18298080 DMI3491 DI DMI3491 DMI3491 DN Apigenin DMI3491 MI TTKPW01 DMI3491 MN Androgen receptor messenger RNA (AR mRNA) DMI3491 MT DTT DMI3491 MA Inhibitor DMI3491 RN Effect of flavonoids on androgen and glucocorticoid receptors based on in vitro reporter gene assay. Bioorg Med Chem Lett. 2009 Aug 15;19(16):4706-10. DMI3491 RU https://pubmed.ncbi.nlm.nih.gov/19592245 DMI3491 DI DMI3491 DMI3491 DN Apigenin DMI3491 MI TTSZLWK DMI3491 MN Aromatase (CYP19A1) DMI3491 MT DTT DMI3491 MA Inhibitor DMI3491 RN Pharmacophore modeling strategies for the development of novel nonsteroidal inhibitors of human aromatase (CYP19). Bioorg Med Chem Lett. 2010 May 15;20(10):3050-64. DMI3491 RU https://pubmed.ncbi.nlm.nih.gov/20413308 DMI3491 DI DMI3491 DMI3491 DN Apigenin DMI3491 MI TTER6YH DMI3491 MN Casein kinase II alpha (CSNK2A1) DMI3491 MT DTT DMI3491 MA Inhibitor DMI3491 RN Structural insight into human CK2alpha in complex with the potent inhibitor ellagic acid. Bioorg Med Chem Lett. 2009 Jun 1;19(11):2920-3. DMI3491 RU https://pubmed.ncbi.nlm.nih.gov/19414254 DMI3491 DI DMI3491 DMI3491 DN Apigenin DMI3491 MI TTO0FDJ DMI3491 MN Cyclin-dependent kinase 6 (CDK6) DMI3491 MT DTT DMI3491 MA Inhibitor DMI3491 RN Crystal structure of a human cyclin-dependent kinase 6 complex with a flavonol inhibitor, fisetin. J Med Chem. 2005 Feb 10;48(3):737-43. DMI3491 RU https://pubmed.ncbi.nlm.nih.gov/15689157 DMI3491 DI DMI3491 DMI3491 DN Apigenin DMI3491 MI TTI84H7 DMI3491 MN Cytochrome P450 1B1 (CYP1B1) DMI3491 MT DTT DMI3491 MA Inhibitor DMI3491 RN Selective inhibition of methoxyflavonoids on human CYP1B1 activity. Bioorg Med Chem. 2010 Sep 1;18(17):6310-5. DMI3491 RU https://pubmed.ncbi.nlm.nih.gov/20696580 DMI3491 DI DMI3491 DMI3491 DN Apigenin DMI3491 MI TTIWB6L DMI3491 MN Estradiol 17 beta-dehydrogenase 1 (17-beta-HSD1) DMI3491 MT DTT DMI3491 MA Inhibitor DMI3491 RN Discovery of nonsteroidal 17beta-hydroxysteroid dehydrogenase 1 inhibitors by pharmacophore-based screening of virtual compound libraries. J Med Chem. 2008 Jul 24;51(14):4188-99. DMI3491 RU https://pubmed.ncbi.nlm.nih.gov/18533708 DMI3491 DI DMI3491 DMI3491 DN Apigenin DMI3491 MI TT50QJ3 DMI3491 MN Influenza Neuraminidase (Influ NA) DMI3491 MT DTT DMI3491 MA Inhibitor DMI3491 RN Neuraminidase inhibitory activities of flavonols isolated from Rhodiola rosea roots and their in vitro anti-influenza viral activities. Bioorg Med Chem. 2009 Oct 1;17(19):6816-23. DMI3491 RU https://pubmed.ncbi.nlm.nih.gov/19729316 DMI3491 DI DMI3491 DMI3491 DN Apigenin DMI3491 MI TTSFWA7 DMI3491 MN Plasmodium CDK Pfmrk (Malaria Pfmrk) DMI3491 MT DTT DMI3491 MA Inhibitor DMI3491 RN A three-dimensional in silico pharmacophore model for inhibition of Plasmodium falciparum cyclin-dependent kinases and discovery of different class... J Med Chem. 2004 Oct 21;47(22):5418-26. DMI3491 RU https://pubmed.ncbi.nlm.nih.gov/15481979 DMIQOXH DI DMIQOXH DMIQOXH DN Apigenin-7-O-beta-D-glucuronide DMIQOXH MI TTFBNVI DMIQOXH MN Aldose reductase (AKR1B1) DMIQOXH MT DTT DMIQOXH MA Inhibitor DMIQOXH RN Erigeroflavanone, a flavanone derivative from the flowers of Erigeron annuus with protein glycation and aldose reductase inhibitory activity. J Nat Prod. 2008 Apr;71(4):713-5. DMIQOXH RU https://pubmed.ncbi.nlm.nih.gov/18298080 DMP7J0I DI DMP7J0I DMP7J0I DN Apigenin-7-O-beta-D-glucuronide methyl ester DMP7J0I MI TTFBNVI DMP7J0I MN Aldose reductase (AKR1B1) DMP7J0I MT DTT DMP7J0I MA Inhibitor DMP7J0I RN Erigeroflavanone, a flavanone derivative from the flowers of Erigeron annuus with protein glycation and aldose reductase inhibitory activity. J Nat Prod. 2008 Apr;71(4):713-5. DMP7J0I RU https://pubmed.ncbi.nlm.nih.gov/18298080 DM6NM8V DI DM6NM8V DM6NM8V DN APLYSAMINE DM6NM8V MI TT9JNIC DM6NM8V MN Histamine H3 receptor (H3R) DM6NM8V MT DTT DM6NM8V MA Inhibitor DM6NM8V RN The alkaloid conessine and analogues as potent histamine H3 receptor antagonists. J Med Chem. 2008 Sep 11;51(17):5423-30. DM6NM8V RU https://pubmed.ncbi.nlm.nih.gov/18683917 DMUPL3J DI DMUPL3J DMUPL3J DN Aplysinopsin DMUPL3J MI TTJQOD7 DMUPL3J MN 5-HT 2A receptor (HTR2A) DMUPL3J MT DTT DMUPL3J MA Inhibitor DMUPL3J RN Synthesis and structure-affinity relationships of novel small molecule natural product derivatives capable of discriminating between serotonin 5-HT1A, 5-HT2A, 5-HT2C receptor subtypes. Bioorg Med Chem. 2010 Jul 1;18(13):4783-92. DMUPL3J RU https://pubmed.ncbi.nlm.nih.gov/20570529 DMUPL3J DI DMUPL3J DMUPL3J DN Aplysinopsin DMUPL3J MI TTWJBZ5 DMUPL3J MN 5-HT 2C receptor (HTR2C) DMUPL3J MT DTT DMUPL3J MA Inhibitor DMUPL3J RN Synthesis and structure-affinity relationships of novel small molecule natural product derivatives capable of discriminating between serotonin 5-HT1A, 5-HT2A, 5-HT2C receptor subtypes. Bioorg Med Chem. 2010 Jul 1;18(13):4783-92. DMUPL3J RU https://pubmed.ncbi.nlm.nih.gov/20570529 DMW45GK DI DMW45GK DMW45GK DN APNEA DMW45GK MI TTNE7KG DMW45GK MN Adenosine A2b receptor (ADORA2B) DMW45GK MT DTT DMW45GK MA Agonist DMW45GK RN Differences in the order of potency for agonists but not antagonists at human and rat adenosine A2A receptors. Biochem Pharmacol. 1999 Jan 1;57(1):65-75. DMW45GK RU https://pubmed.ncbi.nlm.nih.gov/9920286 DM7OPCH DI DM7OPCH DM7OPCH DN Apogossypol DM7OPCH MI TTJGNVC DM7OPCH MN Apoptosis regulator Bcl-2 (BCL-2) DM7OPCH MT DTT DM7OPCH MA Inhibitor DM7OPCH RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7920). DM7OPCH RU http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=7920 DMPH7EO DI DMPH7EO DMPH7EO DN Apomorphine SL DMPH7EO MI TT0R12H DMPH7EO MN Neuron-specific vesicular protein calcyon (CALY) DMPH7EO MT DTT DMPH7EO MA Activator DMPH7EO RN Dopamine and sexual function. Int J Impot Res. 2001 Aug;13 Suppl 3:S18-28. DMPH7EO RU https://pubmed.ncbi.nlm.nih.gov/11477488 DM0VBUL DI DM0VBUL DM0VBUL DN Aprophen DM0VBUL MI TTH18TF DM0VBUL MN Muscarinic acetylcholine receptor M5 (CHRM5) DM0VBUL MT DTT DM0VBUL MA Antagonist DM0VBUL RN The muscarinic antagonists aprophen and benactyzine are noncompetitive inhibitors of the nicotinic acetylcholine receptor. Mol Pharmacol. 1987 Nov;32(5):678-85. DM0VBUL RU https://pubmed.ncbi.nlm.nih.gov/3683366 DM8DOBG DI DM8DOBG DM8DOBG DN APS-3010 DM8DOBG MI TTNDSF4 DM8DOBG MN Proto-oncogene c-Met (MET) DM8DOBG MT DTT DM8DOBG MA Inhibitor DM8DOBG RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1815). DM8DOBG RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1815 DMF1264 DI DMF1264 DMF1264 DN Aptiganel HCl DMF1264 MI TT9IK2Z DMF1264 MN N-methyl-D-aspartate receptor (NMDAR) DMF1264 MT DTT DMF1264 MA Antagonist DMF1264 RN Neuroprotective agents for the treatment of acute ischemic stroke. Curr Neurol Neurosci Rep. 2003 Jan;3(1):9-20. DMF1264 RU https://pubmed.ncbi.nlm.nih.gov/12507405 DMCOMLS DI DMCOMLS DMCOMLS DN APY29 DMCOMLS MI TTOJ9QL DMCOMLS MN Endoplasmic reticulum to nucleus signaling 1 (ERN1) DMCOMLS MT DTT DMCOMLS MA Inhibitor DMCOMLS RN Quercetin ameliorates HFD-induced NAFLD by promoting hepatic VLDL assembly and lipophagy via the IRE1a/XBP1s pathway. Food Chem Toxicol. 2018 Apr;114:52-60. DMCOMLS RU https://pubmed.ncbi.nlm.nih.gov/29438776 DMK2XB7 DI DMK2XB7 DMK2XB7 DN AR-00341677 DMK2XB7 MI TTWCGQT DMK2XB7 MN Serine/threonine-protein kinase B-raf (BRAF) DMK2XB7 MT DTT DMK2XB7 MA Inhibitor DMK2XB7 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5681). DMK2XB7 RU http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=5681 DMUSYKG DI DMUSYKG DMUSYKG DN AR-129330 DMUSYKG MI TTWG9A4 DMUSYKG MN Adrenergic receptor alpha-2A (ADRA2A) DMUSYKG MT DTT DMUSYKG MA Inhibitor DMUSYKG RN Lead optimization of 4-(dimethylamino)quinazolines, potent and selective antagonists for the melanin-concentrating hormone receptor 1. Bioorg Med Chem Lett. 2005 Sep 1;15(17):3853-6. DMUSYKG RU https://pubmed.ncbi.nlm.nih.gov/16002290 DMUSYKG DI DMUSYKG DMUSYKG DN AR-129330 DMUSYKG MI TTX4RTB DMUSYKG MN Melanin-concentrating hormone receptor 1 (MCHR1) DMUSYKG MT DTT DMUSYKG MA Inhibitor DMUSYKG RN Lead optimization of 4-(dimethylamino)quinazolines, potent and selective antagonists for the melanin-concentrating hormone receptor 1. Bioorg Med Chem Lett. 2005 Sep 1;15(17):3853-6. DMUSYKG RU https://pubmed.ncbi.nlm.nih.gov/16002290 DMUSYKG DI DMUSYKG DMUSYKG DN AR-129330 DMUSYKG MI TTY6EWA DMUSYKG MN Neuropeptide Y receptor type 5 (NPY5R) DMUSYKG MT DTT DMUSYKG MA Inhibitor DMUSYKG RN Lead optimization of 4-(dimethylamino)quinazolines, potent and selective antagonists for the melanin-concentrating hormone receptor 1. Bioorg Med Chem Lett. 2005 Sep 1;15(17):3853-6. DMUSYKG RU https://pubmed.ncbi.nlm.nih.gov/16002290 DMN8W46 DI DMN8W46 DMN8W46 DN AR231453 DMN8W46 MI TT7QNVC DMN8W46 MN Glucose-dependent insulinotropic receptor (GPR119) DMN8W46 MT DTT DMN8W46 MA Agonist DMN8W46 RN A role for beta-cell-expressed G protein-coupled receptor 119 in glycemic control by enhancing glucose-dependent insulin release. Endocrinology. 2007 Jun;148(6):2601-9. DMN8W46 RU https://pubmed.ncbi.nlm.nih.gov/17289847 DMTN10D DI DMTN10D DMTN10D DN AR234960 DMTN10D MI TTOISYB DMTN10D MN Proto-oncogene Mas (MAS) DMTN10D MT DTT DMTN10D MA Agonist DMTN10D RN Inhibition of Mas G-protein signaling improves coronary blood flow, reduces myocardial infarct size, and provides long-term cardioprotection. Am J Physiol Heart Circ Physiol. 2012 Jan 1;302(1):H299-311. DMTN10D RU https://pubmed.ncbi.nlm.nih.gov/22003054 DM68QY0 DI DM68QY0 DM68QY0 DN AR244555 DM68QY0 MI TTOISYB DM68QY0 MN Proto-oncogene Mas (MAS) DM68QY0 MT DTT DM68QY0 MA Antagonist DM68QY0 RN Inhibition of Mas G-protein signaling improves coronary blood flow, reduces myocardial infarct size, and provides long-term cardioprotection. Am J Physiol Heart Circ Physiol. 2012 Jan 1;302(1):H299-311. DM68QY0 RU https://pubmed.ncbi.nlm.nih.gov/22003054 DMNJ632 DI DMNJ632 DMNJ632 DN AR-534 DMNJ632 MI TTRZQE3 DMNJ632 MN Glycogen synthase kinase-3 alpha (GSK-3A) DMNJ632 MT DTT DMNJ632 MA Inhibitor DMNJ632 RN A zebrafish model of tauopathy allows in vivo imaging of neuronal cell death and drug evaluation. J Clin Invest. 2009 May;119(5):1382-95. DMNJ632 RU https://pubmed.ncbi.nlm.nih.gov/19363289 DM34P90 DI DM34P90 DM34P90 DN AR-7947 DM34P90 MI TT7QNVC DM34P90 MN Glucose-dependent insulinotropic receptor (GPR119) DM34P90 MT DTT DM34P90 MA Modulator DM34P90 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 126). DM34P90 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=126 DMAM619 DI DMAM619 DMAM619 DN Arabinose-5-Phosphate DMAM619 MI TTVNA43 DMAM619 MN Bacterial Deoxy-D-manno-octulosonate 8-phosphate synthase (Bact kdsA) DMAM619 MT DTT DMAM619 MA Inhibitor DMAM619 RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMAM619 RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMUOQZD DI DMUOQZD DMUOQZD DN Arachidonic acid DMUOQZD MI DEISPU8 DMUOQZD MN Arachidonate 12-lipoxygenase (ALOX12B) DMUOQZD MT DME DMUOQZD MA Metabolism DMUOQZD RN Mitochondrial uncoupling reveals a novel therapeutic opportunity for p53-defective cancers. Nat Commun. 2018 Sep 26;9(1):3931. DMUOQZD RU https://www.ncbi.nlm.nih.gov/pubmed/?term=30258081 DMUOQZD DI DMUOQZD DMUOQZD DN Arachidonic acid DMUOQZD MI DEH0J8X DMUOQZD MN Arachidonate 15-lipoxygenase (ALOX15) DMUOQZD MT DME DMUOQZD MA Metabolism DMUOQZD RN Effect of human 15-lipoxygenase-1 metabolites on vascular function in mouse mesenteric arteries and hearts. Prostaglandins Other Lipid Mediat. 2013 Oct;106:8-15. DMUOQZD RU https://www.ncbi.nlm.nih.gov/pubmed/?term=23872364 DMUOQZD DI DMUOQZD DMUOQZD DN Arachidonic acid DMUOQZD MI DE87OZS DMUOQZD MN Arachidonate 5-lipoxygenase (ALOX5) DMUOQZD MT DME DMUOQZD MA Metabolism DMUOQZD RN A rat air pouch model for evaluating the efficacy and selectivity of 5-lipoxygenase inhibitors. Eur J Pharmacol. 2008 Apr 14;584(1):166-74. DMUOQZD RU https://www.ncbi.nlm.nih.gov/pubmed/?term=18295198 DMUOQZD DI DMUOQZD DMUOQZD DN Arachidonic acid DMUOQZD MI DE5IED8 DMUOQZD MN Cytochrome P450 2C9 (CYP2C9) DMUOQZD MT DME DMUOQZD MA Metabolism DMUOQZD RN New insights into the structural features and functional relevance of human cytochrome P450 2C9. Part I. Curr Drug Metab. 2009 Dec;10(10):1075-126. DMUOQZD RU https://www.ncbi.nlm.nih.gov/pubmed/?term=20167001 DMUOQZD DI DMUOQZD DMUOQZD DN Arachidonic acid DMUOQZD MI DE3GT9C DMUOQZD MN Cytochrome P450 4F2 (CYP4F2) DMUOQZD MT DME DMUOQZD MA Metabolism DMUOQZD RN Role of cytochrome P450 enzymes in the bioactivation of polyunsaturated fatty acids. Biochim Biophys Acta. 2011 Jan;1814(1):210-22. DMUOQZD RU https://www.ncbi.nlm.nih.gov/pubmed/?term=20869469 DMUOQZD DI DMUOQZD DMUOQZD DN Arachidonic acid DMUOQZD MI TT8NGED DMUOQZD MN Prostaglandin G/H synthase 1 (COX-1) DMUOQZD MT DTT DMUOQZD MA Inhibitor DMUOQZD RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMUOQZD RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMUOQZD DI DMUOQZD DMUOQZD DN Arachidonic acid DMUOQZD MI DE073H6 DMUOQZD MN Prostaglandin G/H synthase 1 (COX-1) DMUOQZD MT DME DMUOQZD MA Metabolism DMUOQZD RN Identification and functional characterization of polymorphisms in human cyclooxygenase-1 (PTGS1). Pharmacogenet Genomics. 2007 Feb;17(2):145-60. DMUOQZD RU https://www.ncbi.nlm.nih.gov/pubmed/?term=17301694 DMUOQZD DI DMUOQZD DMUOQZD DN Arachidonic acid DMUOQZD MI DE492CE DMUOQZD MN Prostaglandin G/H synthase 2 (COX-2) DMUOQZD MT DME DMUOQZD MA Metabolism DMUOQZD RN PharmGKB summary: very important pharmacogene information for PTGS2. Pharmacogenet Genomics. 2011 Sep;21(9):607-13. DMUOQZD RU https://www.ncbi.nlm.nih.gov/pubmed/?term=21063235 DMHL48F DI DMHL48F DMHL48F DN ARACHIDONYL TRIFLUOROMETHYLKETONE DMHL48F MI TTT1JVS DMHL48F MN Cytosolic phospholipase A2 (GIVA cPLA2) DMHL48F MT DTT DMHL48F MA Inhibitor DMHL48F RN 85-kDa cPLA(2) plays a critical role in PPAR-mediated gene transcription in human hepatoma cells. Am J Physiol Gastrointest Liver Physiol. 2002 Apr;282(4):G586-97. DMHL48F RU https://pubmed.ncbi.nlm.nih.gov/11897617 DMHL48F DI DMHL48F DMHL48F DN ARACHIDONYL TRIFLUOROMETHYLKETONE DMHL48F MI TTDP1UC DMHL48F MN Fatty acid amide hydrolase (FAAH) DMHL48F MT DTT DMHL48F MA Inhibitor DMHL48F RN 1-Indol-1-yl-propan-2-ones and related heterocyclic compounds as dual inhibitors of cytosolic phospholipase A(2)alpha and fatty acid amide hydrolase. Bioorg Med Chem. 2010 Jan 15;18(2):945-52. DMHL48F RU https://pubmed.ncbi.nlm.nih.gov/20005725 DMZM5KE DI DMZM5KE DMZM5KE DN arachidonylcyclopropylamide DMZM5KE MI TT6OEDT DMZM5KE MN Cannabinoid receptor 1 (CB1) DMZM5KE MT DTT DMZM5KE MA Agonist DMZM5KE RN Synthesis and characterization of potent and selective agonists of the neuronal cannabinoid receptor (CB1). J Pharmacol Exp Ther. 1999 Jun;289(3):1427-33. DMZM5KE RU https://pubmed.ncbi.nlm.nih.gov/10336536 DMZM5KE DI DMZM5KE DMZM5KE DN arachidonylcyclopropylamide DMZM5KE MI TTSLJAR DMZM5KE MN N-arachidonyl glycine receptor (GPR18) DMZM5KE MT DTT DMZM5KE MA Agonist DMZM5KE RN Delta(9) -Tetrahydrocannabinol and N-arachidonyl glycine are full agonists at GPR18 receptors and induce migration in human endometrial HEC-1B cells. Br J Pharmacol. 2012 Apr;165(8):2414-24. DMZM5KE RU https://pubmed.ncbi.nlm.nih.gov/21595653 DMSM1PV DI DMSM1PV DMSM1PV DN ARC-069 DMSM1PV MI TTE4KHA DMSM1PV MN Amyloid beta A4 protein (APP) DMSM1PV MT DTT DMSM1PV MA Inhibitor DMSM1PV RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2402). DMSM1PV RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2402 DMWVULN DI DMWVULN DMWVULN DN AR-C102222 DMWVULN MI TTZUFI5 DMWVULN MN Nitric-oxide synthase brain (NOS1) DMWVULN MT DTT DMWVULN MA Inhibitor DMWVULN RN Anchored plasticity opens doors for selective inhibitor design in nitric oxide synthase. Nat Chem Biol. 2008 Nov;4(11):700-7. DMWVULN RU https://pubmed.ncbi.nlm.nih.gov/18849972 DMWVULN DI DMWVULN DMWVULN DN AR-C102222 DMWVULN MI TTF10I9 DMWVULN MN Nitric-oxide synthase inducible (NOS2) DMWVULN MT DTT DMWVULN MA Inhibitor DMWVULN RN Anchored plasticity opens doors for selective inhibitor design in nitric oxide synthase. Nat Chem Biol. 2008 Nov;4(11):700-7. DMWVULN RU https://pubmed.ncbi.nlm.nih.gov/18849972 DM0KDTG DI DM0KDTG DM0KDTG DN ARC-1028 DM0KDTG MI TTZC6DR DM0KDTG MN cGMP-dependent protein kinase (cGK) DM0KDTG MT DTT DM0KDTG MA Inhibitor DM0KDTG RN Structural analysis of ARC-type inhibitor (ARC-1034) binding to protein kinase A catalytic subunit and rational design of bisubstrate analogue inhi... J Med Chem. 2009 Jan 22;52(2):308-21. DM0KDTG RU https://pubmed.ncbi.nlm.nih.gov/19143565 DMQCPXL DI DMQCPXL DMQCPXL DN AR-C118925XX DMQCPXL MI TTOZHQC DMQCPXL MN P2Y purinoceptor 2 (P2RY2) DMQCPXL MT DTT DMQCPXL MA Antagonist DMQCPXL RN Nucleotide-mediated mucin secretion from differentiated human bronchial epithelial cells. Am J Respir Cell Mol Biol. 2004 Oct;31(4):446-55. DMQCPXL RU https://pubmed.ncbi.nlm.nih.gov/15231488 DMP1EWV DI DMP1EWV DMP1EWV DN AR-C126313 DMP1EWV MI TTOZHQC DMP1EWV MN P2Y purinoceptor 2 (P2RY2) DMP1EWV MT DTT DMP1EWV MA Antagonist DMP1EWV RN Molecular modeling of the human P2Y2 receptor and design of a selective agonist, 2'-amino-2'-deoxy-2-thiouridine 5'-triphosphate. J Med Chem. 2007 Mar 22;50(6):1166-76. DMP1EWV RU https://pubmed.ncbi.nlm.nih.gov/17302398 DM71WQT DI DM71WQT DM71WQT DN AR-C133057XX DM71WQT MI TTZUFI5 DM71WQT MN Nitric-oxide synthase brain (NOS1) DM71WQT MT DTT DM71WQT MA Inhibitor DM71WQT RN Anchored plasticity opens doors for selective inhibitor design in nitric oxide synthase. Nat Chem Biol. 2008 Nov;4(11):700-7. DM71WQT RU https://pubmed.ncbi.nlm.nih.gov/18849972 DM71WQT DI DM71WQT DM71WQT DN AR-C133057XX DM71WQT MI TTF10I9 DM71WQT MN Nitric-oxide synthase inducible (NOS2) DM71WQT MT DTT DM71WQT MA Inhibitor DM71WQT RN Anchored plasticity opens doors for selective inhibitor design in nitric oxide synthase. Nat Chem Biol. 2008 Nov;4(11):700-7. DM71WQT RU https://pubmed.ncbi.nlm.nih.gov/18849972 DMAZV5D DI DMAZV5D DMAZV5D DN ARC-200 DMAZV5D MI TTYFKSZ DMAZV5D MN Tubulin beta (TUBB) DMAZV5D MT DTT DMAZV5D MA Modulator DMAZV5D RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2640). DMAZV5D RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2640 DMU3A57 DI DMU3A57 DMU3A57 DN AR-C70484XX DMU3A57 MI TTT1JVS DMU3A57 MN Cytosolic phospholipase A2 (GIVA cPLA2) DMU3A57 MT DTT DMU3A57 MA Inhibitor DMU3A57 RN 1-Indol-1-yl-propan-2-ones and related heterocyclic compounds as dual inhibitors of cytosolic phospholipase A(2)alpha and fatty acid amide hydrolase. Bioorg Med Chem. 2010 Jan 15;18(2):945-52. DMU3A57 RU https://pubmed.ncbi.nlm.nih.gov/20005725 DMU3A57 DI DMU3A57 DMU3A57 DN AR-C70484XX DMU3A57 MI TTDP1UC DMU3A57 MN Fatty acid amide hydrolase (FAAH) DMU3A57 MT DTT DMU3A57 MA Inhibitor DMU3A57 RN 1-Indol-1-yl-propan-2-ones and related heterocyclic compounds as dual inhibitors of cytosolic phospholipase A(2)alpha and fatty acid amide hydrolase. Bioorg Med Chem. 2010 Jan 15;18(2):945-52. DMU3A57 RU https://pubmed.ncbi.nlm.nih.gov/20005725 DMXOYK0 DI DMXOYK0 DMXOYK0 DN Arcaine DMXOYK0 MI TTLGDIS DMXOYK0 MN Acid-sensing ion channel 3 (ASIC3) DMXOYK0 MT DTT DMXOYK0 MA Activator DMXOYK0 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 686). DMXOYK0 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=686 DM03E28 DI DM03E28 DM03E28 DN ARD-412 DM03E28 MI TT27RFC DM03E28 MN Opioid receptor delta (OPRD1) DM03E28 MT DTT DM03E28 MA Agonist DM03E28 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 317). DM03E28 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=317 DMSA6IY DI DMSA6IY DMSA6IY DN arecaidine propargyl ester DMSA6IY MI TTOXS3C DMSA6IY MN Muscarinic acetylcholine receptor (CHRM) DMSA6IY MT DTT DMSA6IY MA Agonist DMSA6IY RN Positive cooperativity of acetylcholine and other agonists with allosteric ligands on muscarinic acetylcholine receptors. Mol Pharmacol. 1997 Jul;52(1):172-9. DMSA6IY RU https://pubmed.ncbi.nlm.nih.gov/9224827 DMSA6IY DI DMSA6IY DMSA6IY DN arecaidine propargyl ester DMSA6IY MI TTQ13Z5 DMSA6IY MN Muscarinic acetylcholine receptor M3 (CHRM3) DMSA6IY MT DTT DMSA6IY MA Agonist DMSA6IY RN Positive cooperativity of acetylcholine and other agonists with allosteric ligands on muscarinic acetylcholine receptors. Mol Pharmacol. 1997 Jul;52(1):172-9. DMSA6IY RU https://pubmed.ncbi.nlm.nih.gov/9224827 DM8KN0Q DI DM8KN0Q DM8KN0Q DN ARGENINE VASOPRESSIN DM8KN0Q MI TTSCIUP DM8KN0Q MN Oxytocin receptor (OTR) DM8KN0Q MT DTT DM8KN0Q MA Inhibitor DM8KN0Q RN Design and synthesis of the first selective agonists for the rat vasopressin V(1b) receptor: based on modifications of deamino-[Cys1]arginine vasop... J Med Chem. 2007 Feb 22;50(4):835-47. DM8KN0Q RU https://pubmed.ncbi.nlm.nih.gov/17300166 DM8KN0Q DI DM8KN0Q DM8KN0Q DN ARGENINE VASOPRESSIN DM8KN0Q MI TT4TFGN DM8KN0Q MN Vasopressin V1a receptor (V1AR) DM8KN0Q MT DTT DM8KN0Q MA Inhibitor DM8KN0Q RN Design and synthesis of the first selective agonists for the rat vasopressin V(1b) receptor: based on modifications of deamino-[Cys1]arginine vasop... J Med Chem. 2007 Feb 22;50(4):835-47. DM8KN0Q RU https://pubmed.ncbi.nlm.nih.gov/17300166 DM8KN0Q DI DM8KN0Q DM8KN0Q DN ARGENINE VASOPRESSIN DM8KN0Q MI TTL9MHW DM8KN0Q MN Vasopressin V1b receptor (V1BR) DM8KN0Q MT DTT DM8KN0Q MA Inhibitor DM8KN0Q RN Design and synthesis of the first selective agonists for the rat vasopressin V(1b) receptor: based on modifications of deamino-[Cys1]arginine vasop... J Med Chem. 2007 Feb 22;50(4):835-47. DM8KN0Q RU https://pubmed.ncbi.nlm.nih.gov/17300166 DM8KN0Q DI DM8KN0Q DM8KN0Q DN ARGENINE VASOPRESSIN DM8KN0Q MI TTK8R02 DM8KN0Q MN Vasopressin V2 receptor (V2R) DM8KN0Q MT DTT DM8KN0Q MA Inhibitor DM8KN0Q RN Design and synthesis of the first selective agonists for the rat vasopressin V(1b) receptor: based on modifications of deamino-[Cys1]arginine vasop... J Med Chem. 2007 Feb 22;50(4):835-47. DM8KN0Q RU https://pubmed.ncbi.nlm.nih.gov/17300166 DMQ1DWU DI DMQ1DWU DMQ1DWU DN Argiotoxin-636 DMQ1DWU MI TTVPQTF DMQ1DWU MN Glutamate receptor AMPA 1 (GRIA1) DMQ1DWU MT DTT DMQ1DWU MA Inhibitor DMQ1DWU RN Developing a complete pharmacology for AMPA receptors: a perspective on subtype-selective ligands. Bioorg Med Chem. 2010 Feb 15;18(4):1381-7. DMQ1DWU RU https://pubmed.ncbi.nlm.nih.gov/20096591 DM6PA1S DI DM6PA1S DM6PA1S DN Arg-Pro-Lys-Pro-Ala-Gln-Phe-Phe-Gly-Leu-Met-NH2 DM6PA1S MI TTZPO1L DM6PA1S MN Substance-P receptor (TACR1) DM6PA1S MT DTT DM6PA1S MA Inhibitor DM6PA1S RN Conformational comparisons of a series of tachykinin peptide analogs. J Med Chem. 2007 Dec 27;50(26):6501-6. DM6PA1S RU https://pubmed.ncbi.nlm.nih.gov/18067242 DMYM91S DI DMYM91S DMYM91S DN Arg-Pro-Lys-Pro-Ala-Ser-Phe-Phe-Gly-Leu-Met-NH2 DMYM91S MI TTZPO1L DMYM91S MN Substance-P receptor (TACR1) DMYM91S MT DTT DMYM91S MA Inhibitor DMYM91S RN Conformational comparisons of a series of tachykinin peptide analogs. J Med Chem. 2007 Dec 27;50(26):6501-6. DMYM91S RU https://pubmed.ncbi.nlm.nih.gov/18067242 DMA318X DI DMA318X DMA318X DN Arg-Pro-Lys-Pro-Gln-Ser-Phe-Phe-Gly-Leu-Met-NH2 DMA318X MI TTZPO1L DMA318X MN Substance-P receptor (TACR1) DMA318X MT DTT DMA318X MA Inhibitor DMA318X RN Conformational comparisons of a series of tachykinin peptide analogs. J Med Chem. 2007 Dec 27;50(26):6501-6. DMA318X RU https://pubmed.ncbi.nlm.nih.gov/18067242 DM8NETP DI DM8NETP DM8NETP DN ARH-1029 DM8NETP MI TTF1QVM DM8NETP MN Gastric H(+)/K(+) ATPase alpha (ATP4A) DM8NETP MT DTT DM8NETP MA Modulator DM8NETP RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 849). DM8NETP RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=849 DM2PRHX DI DM2PRHX DM2PRHX DN AR-HO29953XX DM2PRHX MI TTTO43N DM2PRHX MN Endothelial plasminogen activator inhibitor (SERPINE1) DM2PRHX MT DTT DM2PRHX MA Inhibitor DM2PRHX RN Synthesis and SAR of 2-carboxylic acid indoles as inhibitors of plasminogen activator inhibitor-1. Bioorg Med Chem Lett. 2005 Aug 1;15(15):3514-8. DM2PRHX RU https://pubmed.ncbi.nlm.nih.gov/15982877 DMIMD0T DI DMIMD0T DMIMD0T DN ARI-3099 DMIMD0T MI TTYWEDQ DMIMD0T MN Acylamino-acid-releasing enzyme (APEH) DMIMD0T MT DTT DMIMD0T MA Inhibitor DMIMD0T RN A high-throughput, multiplexed assay for superfamily-wide profiling of enzyme activity. Nat Chem Biol. 2014 Aug;10(8):656-63. DMIMD0T RU https://pubmed.ncbi.nlm.nih.gov/24997602 DMIMD0T DI DMIMD0T DMIMD0T DN ARI-3099 DMIMD0T MI TTGPQ0F DMIMD0T MN Prolyl endopeptidase FAP (FAP) DMIMD0T MT DTT DMIMD0T MA Inhibitor DMIMD0T RN Identification of selective and potent inhibitors of fibroblast activation protein and prolyl oligopeptidase. J Med Chem. 2013 May 9;56(9):3467-77. DMIMD0T RU https://pubmed.ncbi.nlm.nih.gov/23594271 DMEO82V DI DMEO82V DMEO82V DN ARI-3531 DMEO82V MI TTNGKET DMEO82V MN Prolyl endopeptidase (PREP) DMEO82V MT DTT DMEO82V MA Inhibitor DMEO82V RN Identification of selective and potent inhibitors of fibroblast activation protein and prolyl oligopeptidase. J Med Chem. 2013 May 9;56(9):3467-77. DMEO82V RU https://pubmed.ncbi.nlm.nih.gov/23594271 DMNPEM4 DI DMNPEM4 DMNPEM4 DN ARL66096 DMNPEM4 MI TTZ1DT0 DMNPEM4 MN P2Y purinoceptor 12 (P2RY12) DMNPEM4 MT DTT DMNPEM4 MA Antagonist DMNPEM4 RN FPL 66096: a novel, highly potent and selective antagonist at human platelet P2T-purinoceptors. Br J Pharmacol. 1994 Nov;113(3):1057-63. DMNPEM4 RU https://pubmed.ncbi.nlm.nih.gov/7858849 DM24MKI DI DM24MKI DM24MKI DN AR-mTOR-26 DM24MKI MI TTCJG29 DM24MKI MN Serine/threonine-protein kinase mTOR (mTOR) DM24MKI MT DTT DM24MKI MA Inhibitor DM24MKI RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2109). DM24MKI RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2109 DMBE0H8 DI DMBE0H8 DMBE0H8 DN ARN-2966 DMBE0H8 MI TTE4KHA DMBE0H8 MN Amyloid beta A4 protein (APP) DMBE0H8 MT DTT DMBE0H8 MA Inhibitor DMBE0H8 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2402). DMBE0H8 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2402 DMMCFEX DI DMMCFEX DMMCFEX DN ARN34 DMMCFEX MI TTS64P2 DMMCFEX MN Androgen receptor (AR) DMMCFEX MT DTT DMMCFEX MA Antagonist DMMCFEX RN Ectopic expression of the amino-terminal peptide of androgen receptor leads to androgen receptor dysfunction and inhibition of androgen receptor-mediated prostate cancer growth. Mol Cell Endocrinol. 2004 Feb 12;214(1-2):175-87. DMMCFEX RU https://pubmed.ncbi.nlm.nih.gov/15062556 DMNAJQY DI DMNAJQY DMNAJQY DN ARO 087 DMNAJQY MI TT0LF7H DMNAJQY MN Fibroblast growth factor receptor (FGFR) DMNAJQY MT DTT DMNAJQY MA Modulator DMNAJQY RN J Clin Oncol 33, 2015 (suppl; abstr 2545). DMNAJQY RU http://meetinglibrary.asco.org/content/149025-156 DM6KQXF DI DM6KQXF DM6KQXF DN ARP100 DM6KQXF MI TT6X50U DM6KQXF MN Matrix metalloproteinase-9 (MMP-9) DM6KQXF MT DTT DM6KQXF MA Inhibitor DM6KQXF RN Amber force field implementation, molecular modelling study, synthesis and MMP-1/MMP-2 inhibition profile of (R)- and (S)-N-hydroxy-2-(N-isopropoxy... Bioorg Med Chem. 2006 Jun 15;14(12):4260-76. DM6KQXF RU https://pubmed.ncbi.nlm.nih.gov/16483784 DMU70YP DI DMU70YP DMU70YP DN ARPFAQK-FAM DMU70YP MI TTK3WBU DMU70YP MN XIAP messenger RNA (XIAP mRNA) DMU70YP MT DTT DMU70YP MA Inhibitor DMU70YP RN Discovery of embelin as a cell-permeable, small-molecular weight inhibitor of XIAP through structure-based computational screening of a traditional... J Med Chem. 2004 May 6;47(10):2430-40. DMU70YP RU https://pubmed.ncbi.nlm.nih.gov/15115387 DMB9PDA DI DMB9PDA DMB9PDA DN arpromidine DMB9PDA MI TTTIBOJ DMB9PDA MN Histamine H1 receptor (H1R) DMB9PDA MT DTT DMB9PDA MA Antagonist DMB9PDA RN Multiple differences in agonist and antagonist pharmacology between human and guinea pig histamine H1-receptor. J Pharmacol Exp Ther. 2003 Jun;305(3):1104-15. DMB9PDA RU https://pubmed.ncbi.nlm.nih.gov/12626648 DMB9PDA DI DMB9PDA DMB9PDA DN arpromidine DMB9PDA MI TTQHJ1K DMB9PDA MN Histamine H2 receptor (H2R) DMB9PDA MT DTT DMB9PDA MA Agonist DMB9PDA RN Probing ligand-specific histamine H1- and H2-receptor conformations with NG-acylated Imidazolylpropylguanidines. J Pharmacol Exp Ther. 2006 Apr;317(1):139-46. DMB9PDA RU https://pubmed.ncbi.nlm.nih.gov/16394198 DMIRTF5 DI DMIRTF5 DMIRTF5 DN ARRY-575 DMIRTF5 MI TTTU902 DMIRTF5 MN Checkpoint kinase-1 (CHK1) DMIRTF5 MT DTT DMIRTF5 MA Inhibitor DMIRTF5 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1987). DMIRTF5 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1987 DMBCO4Q DI DMBCO4Q DMBCO4Q DN Arsenite DMBCO4Q MI DTH6X7Q DMBCO4Q MN Feline leukemia virus subgroup C receptor-related protein 1 (SLC49A1) DMBCO4Q MT DTP DMBCO4Q MA Substrate DMBCO4Q RN The Transporter Classification Database (TCDB): recent advances. Nucleic Acids Res. 2016 Jan 4;44(D1):D372-9. (ID: 2.A.1.28.1) DMBCO4Q RU http://www.tcdb.org/search/result.php?tc=2.A.1.28.1 DMBCO4Q DI DMBCO4Q DMBCO4Q DN Arsenite DMBCO4Q MI DTG3T6X DMBCO4Q MN Glucose transporter type 1, erythrocyte/brain (SLC2A1) DMBCO4Q MT DTP DMBCO4Q MA Substrate DMBCO4Q RN Mammalian glucose permease GLUT1 facilitates transport of arsenic trioxide and methylarsonous acid. Biochem Biophys Res Commun. 2006 Dec 15;351(2):424-30. DMBCO4Q RU http://www.ncbi.nlm.nih.gov/pubmed/17064664 DMBCO4Q DI DMBCO4Q DMBCO4Q DN Arsenite DMBCO4Q MI TTRPDBG DMBCO4Q MN Inhibitor of nuclear factor kappa-B kinase (IKK) DMBCO4Q MT DTT DMBCO4Q MA Inhibitor DMBCO4Q RN Inhibition of NF-kappa B activation by arsenite through reaction with a critical cysteine in the activation loop of Ikappa B kinase. J Biol Chem. 2000 Nov 17;275(46):36062-6. DMBCO4Q RU https://pubmed.ncbi.nlm.nih.gov/10967126 DMBCO4Q DI DMBCO4Q DMBCO4Q DN Arsenite DMBCO4Q MI DTSYQGK DMBCO4Q MN Multidrug resistance-associated protein 1 (ABCC1) DMBCO4Q MT DTP DMBCO4Q MA Substrate DMBCO4Q RN Comparative Molecular Docking Studies with ABCC1 and Aquaporin 9 in the Arsenite Complex Efflux. Bioinformation. 2014 Aug 30;10(8):474-9. DMBCO4Q RU http://www.ncbi.nlm.nih.gov/pubmed/25258480 DMEVT4I DI DMEVT4I DMEVT4I DN ART-144 DMEVT4I MI TTR9XHZ DMEVT4I MN Transforming growth factor beta 1 (TGFB1) DMEVT4I MT DTT DMEVT4I MA Modulator DMEVT4I RN Pharmaceutical products of TORREYA partners. December 2011. DMEVT4I RU http://www.availablepharmaproducts.com/app_dec11.pdf DM8SP4X DI DM8SP4X DM8SP4X DN Arteminolide DM8SP4X MI TT7WZIJ DM8SP4X MN CAAX farnesyltransferase beta (FNTB) DM8SP4X MT DTT DM8SP4X MA Inhibitor DM8SP4X RN Modeling of binding modes and inhibition mechanism of some natural ligands of farnesyl transferase using molecular docking. J Med Chem. 2002 Mar 28;45(7):1460-5. DM8SP4X RU https://pubmed.ncbi.nlm.nih.gov/11906287 DMWCDM8 DI DMWCDM8 DMWCDM8 DN artepillin C DMWCDM8 MI TTELV3W DMWCDM8 MN Transformation-sensitive protein p120 (TRPA1) DMWCDM8 MT DTT DMWCDM8 MA Activator DMWCDM8 RN Artepillin C, a major ingredient of Brazilian propolis, induces a pungent taste by activating TRPA1 channels. PLoS One. 2012;7(11):e48072. DMWCDM8 RU https://pubmed.ncbi.nlm.nih.gov/23133611 DMB9AR7 DI DMB9AR7 DMB9AR7 DN ARTOBILOXANTHONE DMB9AR7 MI TTSXVID DMB9AR7 MN Nuclear factor NF-kappa-B (NFKB) DMB9AR7 MT DTT DMB9AR7 MA Inhibitor DMB9AR7 RN Cytotoxic and NF-kappaB inhibitory constituents of Artocarpus rigida. J Nat Prod. 2010 May 28;73(5):949-55. DMB9AR7 RU https://pubmed.ncbi.nlm.nih.gov/20384315 DMHUXRP DI DMHUXRP DMHUXRP DN ARTORIGIDIN A DMHUXRP MI TTSXVID DMHUXRP MN Nuclear factor NF-kappa-B (NFKB) DMHUXRP MT DTT DMHUXRP MA Inhibitor DMHUXRP RN Cytotoxic and NF-kappaB inhibitory constituents of Artocarpus rigida. J Nat Prod. 2010 May 28;73(5):949-55. DMHUXRP RU https://pubmed.ncbi.nlm.nih.gov/20384315 DMO5LUF DI DMO5LUF DMO5LUF DN arvanil DMO5LUF MI TTMI6F5 DMO5LUF MN Transient receptor potential cation channel V1 (TRPV1) DMO5LUF MT DTT DMO5LUF MA Activator DMO5LUF RN Cloning and pharmacological characterization of mouse TRPV1. Neurosci Lett. 2004 Nov 3;370(1):55-60. DMO5LUF RU https://pubmed.ncbi.nlm.nih.gov/15489017 DM15KLR DI DM15KLR DM15KLR DN ARX-AHD DM15KLR MI TTGKNB4 DM15KLR MN Epidermal growth factor receptor (EGFR) DM15KLR MT DTT DM15KLR RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1797). DM15KLR RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1797 DMWHUKZ DI DMWHUKZ DMWHUKZ DN AR-XYZ DMWHUKZ MI TTMSFAW DMWHUKZ MN Cannabinoid receptor 2 (CB2) DMWHUKZ MT DTT DMWHUKZ MA Agonist DMWHUKZ RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 57). DMWHUKZ RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=57 DMAWJPE DI DMAWJPE DMAWJPE DN AS04 DMAWJPE MI TTISGCA DMAWJPE MN Toll-like receptor 4 (TLR4) DMAWJPE MT DTT DMAWJPE MA Modulator DMAWJPE RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1754). DMAWJPE RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1754 DMXZ8S9 DI DMXZ8S9 DMXZ8S9 DN AS100 DMXZ8S9 MI TTK25J1 DMXZ8S9 MN Adenosine A1 receptor (ADORA1) DMXZ8S9 MT DTT DMXZ8S9 MA Antagonist DMXZ8S9 RN Pharmacological characterization of novel adenosine ligands in recombinant and native human A2B receptors. Biochem Pharmacol. 2005 Nov 25;70(11):1601-12. DMXZ8S9 RU https://pubmed.ncbi.nlm.nih.gov/16219300 DMXZ8S9 DI DMXZ8S9 DMXZ8S9 DN AS100 DMXZ8S9 MI TTNE7KG DMXZ8S9 MN Adenosine A2b receptor (ADORA2B) DMXZ8S9 MT DTT DMXZ8S9 MA Antagonist DMXZ8S9 RN Pharmacological characterization of novel adenosine ligands in recombinant and native human A2B receptors. Biochem Pharmacol. 2005 Nov 25;70(11):1601-12. DMXZ8S9 RU https://pubmed.ncbi.nlm.nih.gov/16219300 DM170G5 DI DM170G5 DM170G5 DN AS1269574 DM170G5 MI TT7QNVC DM170G5 MN Glucose-dependent insulinotropic receptor (GPR119) DM170G5 MT DTT DM170G5 MA Agonist DM170G5 RN Identification of a novel GPR119 agonist, AS1269574, with in vitro and in vivo glucose-stimulated insulin secretion. Biochem Biophys Res Commun. 2010 Sep 24;400(3):437-41. DM170G5 RU https://pubmed.ncbi.nlm.nih.gov/20804735 DMPX5SJ DI DMPX5SJ DMPX5SJ DN AS-1397 DMPX5SJ MI TTEB0GD DMPX5SJ MN Cholinesterase (BCHE) DMPX5SJ MT DTT DMPX5SJ MA Inhibitor DMPX5SJ RN Novel heterobivalent tacrine derivatives as cholinesterase inhibitors with notable selectivity toward butyrylcholinesterase. J Med Chem. 2006 Dec 14;49(25):7540-4. DMPX5SJ RU https://pubmed.ncbi.nlm.nih.gov/17149883 DM7A8PX DI DM7A8PX DM7A8PX DN AS-1522489-00 DM7A8PX MI TTHJTF7 DM7A8PX MN Glycine transporter GlyT-1 (SLC6A9) DM7A8PX MT DTT DM7A8PX MA Inhibitor DM7A8PX RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 935). DM7A8PX RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=935 DMP0A17 DI DMP0A17 DMP0A17 DN AS16 DMP0A17 MI TTNE7KG DMP0A17 MN Adenosine A2b receptor (ADORA2B) DMP0A17 MT DTT DMP0A17 MA Antagonist DMP0A17 RN Pharmacological characterization of novel adenosine ligands in recombinant and native human A2B receptors. Biochem Pharmacol. 2005 Nov 25;70(11):1601-12. DMP0A17 RU https://pubmed.ncbi.nlm.nih.gov/16219300 DM6MWDH DI DM6MWDH DM6MWDH DN AS-1708727 DM6MWDH MI TTHAVTS DM6MWDH MN Forkhead box protein O1A (FOXO1) DM6MWDH MT DTT DM6MWDH MA Modulator DM6MWDH RN Effects of the novel Foxo1 inhibitor AS1708727 on plasma glucose and triglyceride levels in diabetic db/db mice. Eur J Pharmacol. 2010 Oct 25;645(1-3):185-91. DM6MWDH RU https://pubmed.ncbi.nlm.nih.gov/20655898 DMS86PI DI DMS86PI DMS86PI DN AS-1892802 DMS86PI MI TTZN7RP DMS86PI MN Rho-associated protein kinase 1 (ROCK1) DMS86PI MT DTT DMS86PI MA Inhibitor DMS86PI RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1503). DMS86PI RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1503 DMASE5O DI DMASE5O DMASE5O DN AS-19 DMASE5O MI TTO9X1H DMASE5O MN 5-HT 7 receptor (HTR7) DMASE5O MT DTT DMASE5O MA Agonist DMASE5O RN Discovery of aryl-biphenyl-2-ylmethylpiperazines as novel scaffolds for 5-HT(7) ligands and role of the aromatic substituents in binding to the target receptor. Bioorg Med Chem. 2013 May 1;21(9):2568-76. DMASE5O RU https://pubmed.ncbi.nlm.nih.gov/23541835 DM0MAIW DI DM0MAIW DM0MAIW DN AS-1907417 DM0MAIW MI TT7QNVC DM0MAIW MN Glucose-dependent insulinotropic receptor (GPR119) DM0MAIW MT DTT DM0MAIW MA Agonist DM0MAIW RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 126). DM0MAIW RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=126 DMQ95EB DI DMQ95EB DMQ95EB DN AS-601245 DMQ95EB MI TTRSMW9 DMQ95EB MN Glycogen synthase kinase-3 beta (GSK-3B) DMQ95EB MT DTT DMQ95EB MA Inhibitor DMQ95EB RN The selectivity of protein kinase inhibitors: a further update. Biochem J. 2007 Dec 15;408(3):297-315. DMQ95EB RU https://pubmed.ncbi.nlm.nih.gov/17850214 DMQ95EB DI DMQ95EB DMQ95EB DN AS-601245 DMQ95EB MI TT3IVG2 DMQ95EB MN JNK2 messenger RNA (JNK2 mRNA) DMQ95EB MT DTT DMQ95EB MA Inhibitor DMQ95EB RN The selectivity of protein kinase inhibitors: a further update. Biochem J. 2007 Dec 15;408(3):297-315. DMQ95EB RU https://pubmed.ncbi.nlm.nih.gov/17850214 DMQ95EB DI DMQ95EB DMQ95EB DN AS-601245 DMQ95EB MI TT0K6EO DMQ95EB MN Stress-activated protein kinase JNK1 (JNK1) DMQ95EB MT DTT DMQ95EB MA Inhibitor DMQ95EB RN The selectivity of protein kinase inhibitors: a further update. Biochem J. 2007 Dec 15;408(3):297-315. DMQ95EB RU https://pubmed.ncbi.nlm.nih.gov/17850214 DMQ95EB DI DMQ95EB DMQ95EB DN AS-601245 DMQ95EB MI TT056SO DMQ95EB MN Stress-activated protein kinase JNK3 (JNK3) DMQ95EB MT DTT DMQ95EB MA Inhibitor DMQ95EB RN A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases. Proc Natl Acad Sci U S A. 2007 Dec 18;104(51):20523-8. DMQ95EB RU https://pubmed.ncbi.nlm.nih.gov/18077363 DMANU3W DI DMANU3W DMANU3W DN AS-602704 DMANU3W MI TTE4KHA DMANU3W MN Amyloid beta A4 protein (APP) DMANU3W MT DTT DMANU3W MA Modulator DMANU3W RN Transport characteristics of a beta sheet breaker peptide across excised bovine nasal mucosa. Drug Dev Ind Pharm. 2007 Jan;33(1):71-7. DMANU3W RU https://www.ncbi.nlm.nih.gov/pubmed/17192253 DM9IUSM DI DM9IUSM DM9IUSM DN AS-604850 DM9IUSM MI TTHBTOP DM9IUSM MN PI3-kinase gamma (PIK3CG) DM9IUSM MT DTT DM9IUSM MA Inhibitor DM9IUSM RN Blockade of PI3Kgamma suppresses joint inflammation and damage in mouse models of rheumatoid arthritis. Nat Med. 2005 Sep;11(9):936-43. DM9IUSM RU https://pubmed.ncbi.nlm.nih.gov/16127437 DM9V5GS DI DM9V5GS DM9V5GS DN AS604872 DM9V5GS MI TTT2ZAR DM9V5GS MN Prostaglandin F2-alpha receptor (PTGFR) DM9V5GS MT DTT DM9V5GS MA Antagonist DM9V5GS RN Arrest of preterm labor in rat and mouse by an oral and selective nonprostanoid antagonist of the prostaglandin F2alpha receptor (FP). Am J Obstet Gynecol. 2007 Jul;197(1):54.e1-9. DM9V5GS RU https://pubmed.ncbi.nlm.nih.gov/17618756 DM9CIJP DI DM9CIJP DM9CIJP DN AS70 DM9CIJP MI TTK25J1 DM9CIJP MN Adenosine A1 receptor (ADORA1) DM9CIJP MT DTT DM9CIJP MA Antagonist DM9CIJP RN Pharmacological characterization of novel adenosine ligands in recombinant and native human A2B receptors. Biochem Pharmacol. 2005 Nov 25;70(11):1601-12. DM9CIJP RU https://pubmed.ncbi.nlm.nih.gov/16219300 DM9CIJP DI DM9CIJP DM9CIJP DN AS70 DM9CIJP MI TTNE7KG DM9CIJP MN Adenosine A2b receptor (ADORA2B) DM9CIJP MT DTT DM9CIJP MA Antagonist DM9CIJP RN Pharmacological characterization of novel adenosine ligands in recombinant and native human A2B receptors. Biochem Pharmacol. 2005 Nov 25;70(11):1601-12. DM9CIJP RU https://pubmed.ncbi.nlm.nih.gov/16219300 DMZPHKG DI DMZPHKG DMZPHKG DN AS74 DMZPHKG MI TTNE7KG DMZPHKG MN Adenosine A2b receptor (ADORA2B) DMZPHKG MT DTT DMZPHKG MA Antagonist DMZPHKG RN Pharmacological characterization of novel adenosine ligands in recombinant and native human A2B receptors. Biochem Pharmacol. 2005 Nov 25;70(11):1601-12. DMZPHKG RU https://pubmed.ncbi.nlm.nih.gov/16219300 DM7WJ6F DI DM7WJ6F DM7WJ6F DN AS94 DM7WJ6F MI TTNE7KG DM7WJ6F MN Adenosine A2b receptor (ADORA2B) DM7WJ6F MT DTT DM7WJ6F MA Antagonist DM7WJ6F RN Pharmacological characterization of novel adenosine ligands in recombinant and native human A2B receptors. Biochem Pharmacol. 2005 Nov 25;70(11):1601-12. DM7WJ6F RU https://pubmed.ncbi.nlm.nih.gov/16219300 DMN3E9Q DI DMN3E9Q DMN3E9Q DN AS95 DMN3E9Q MI TTNE7KG DMN3E9Q MN Adenosine A2b receptor (ADORA2B) DMN3E9Q MT DTT DMN3E9Q MA Antagonist DMN3E9Q RN Pharmacological characterization of novel adenosine ligands in recombinant and native human A2B receptors. Biochem Pharmacol. 2005 Nov 25;70(11):1601-12. DMN3E9Q RU https://pubmed.ncbi.nlm.nih.gov/16219300 DML6I8J DI DML6I8J DML6I8J DN AS96 DML6I8J MI TTNE7KG DML6I8J MN Adenosine A2b receptor (ADORA2B) DML6I8J MT DTT DML6I8J MA Antagonist DML6I8J RN Pharmacological characterization of novel adenosine ligands in recombinant and native human A2B receptors. Biochem Pharmacol. 2005 Nov 25;70(11):1601-12. DML6I8J RU https://pubmed.ncbi.nlm.nih.gov/16219300 DMR01O4 DI DMR01O4 DMR01O4 DN AS-9705 DMR01O4 MI TT4C8EA DMR01O4 MN Dopamine D3 receptor (D3R) DMR01O4 MT DTT DMR01O4 MA Antagonist DMR01O4 RN Emerging drugs for chemotherapy-induced emesis. Expert Opin Emerg Drugs. 2006 Mar;11(1):137-51. DMR01O4 RU https://pubmed.ncbi.nlm.nih.gov/16503832 DMZ7FJN DI DMZ7FJN DMZ7FJN DN AS99 DMZ7FJN MI TTK25J1 DMZ7FJN MN Adenosine A1 receptor (ADORA1) DMZ7FJN MT DTT DMZ7FJN MA Antagonist DMZ7FJN RN Pharmacological characterization of novel adenosine ligands in recombinant and native human A2B receptors. Biochem Pharmacol. 2005 Nov 25;70(11):1601-12. DMZ7FJN RU https://pubmed.ncbi.nlm.nih.gov/16219300 DMZ7FJN DI DMZ7FJN DMZ7FJN DN AS99 DMZ7FJN MI TTNE7KG DMZ7FJN MN Adenosine A2b receptor (ADORA2B) DMZ7FJN MT DTT DMZ7FJN MA Antagonist DMZ7FJN RN Pharmacological characterization of novel adenosine ligands in recombinant and native human A2B receptors. Biochem Pharmacol. 2005 Nov 25;70(11):1601-12. DMZ7FJN RU https://pubmed.ncbi.nlm.nih.gov/16219300 DM3WVPJ DI DM3WVPJ DM3WVPJ DN Asacolitin DM3WVPJ MI DEFHZW7 DM3WVPJ MN Arylamine N-acetyltransferase (NAT) DM3WVPJ MT DME DM3WVPJ MA Metabolism DM3WVPJ RN Identification and functional characterization of arylamine N-acetyltransferases in eubacteria: evidence for highly selective acetylation of 5-aminosalicylic acid. J Bacteriol. 2001 Jun;183(11):3417-27. DM3WVPJ RU https://www.ncbi.nlm.nih.gov/pubmed/?term=11344150 DM3WVPJ DI DM3WVPJ DM3WVPJ DN Asacolitin DM3WVPJ MI DE97F4R DM3WVPJ MN Arylamine N-acetyltransferase (NAT) DM3WVPJ MT DME DM3WVPJ MA Metabolism DM3WVPJ RN Identification and functional characterization of arylamine N-acetyltransferases in eubacteria: evidence for highly selective acetylation of 5-aminosalicylic acid. J Bacteriol. 2001 Jun;183(11):3417-27. DM3WVPJ RU https://www.ncbi.nlm.nih.gov/pubmed/?term=11344150 DM3WVPJ DI DM3WVPJ DM3WVPJ DN Asacolitin DM3WVPJ MI DEKBP7I DM3WVPJ MN Arylamine N-acetyltransferase (NAT) DM3WVPJ MT DME DM3WVPJ MA Metabolism DM3WVPJ RN Identification and functional characterization of arylamine N-acetyltransferases in eubacteria: evidence for highly selective acetylation of 5-aminosalicylic acid. J Bacteriol. 2001 Jun;183(11):3417-27. DM3WVPJ RU https://www.ncbi.nlm.nih.gov/pubmed/?term=11344150 DM3WVPJ DI DM3WVPJ DM3WVPJ DN Asacolitin DM3WVPJ MI DEPI0ME DM3WVPJ MN Arylamine N-acetyltransferase (NAT) DM3WVPJ MT DME DM3WVPJ MA Metabolism DM3WVPJ RN Identification and functional characterization of arylamine N-acetyltransferases in eubacteria: evidence for highly selective acetylation of 5-aminosalicylic acid. J Bacteriol. 2001 Jun;183(11):3417-27. DM3WVPJ RU https://www.ncbi.nlm.nih.gov/pubmed/?term=11344150 DM3WVPJ DI DM3WVPJ DM3WVPJ DN Asacolitin DM3WVPJ MI DE5DY7B DM3WVPJ MN Arylamine N-acetyltransferase (NAT) DM3WVPJ MT DME DM3WVPJ MA Metabolism DM3WVPJ RN Identification and functional characterization of arylamine N-acetyltransferases in eubacteria: evidence for highly selective acetylation of 5-aminosalicylic acid. J Bacteriol. 2001 Jun;183(11):3417-27. DM3WVPJ RU https://www.ncbi.nlm.nih.gov/pubmed/?term=11344150 DM3WVPJ DI DM3WVPJ DM3WVPJ DN Asacolitin DM3WVPJ MI DE2S6QE DM3WVPJ MN Arylamine N-acetyltransferase (NAT) DM3WVPJ MT DME DM3WVPJ MA Metabolism DM3WVPJ RN Identification and functional characterization of arylamine N-acetyltransferases in eubacteria: evidence for highly selective acetylation of 5-aminosalicylic acid. J Bacteriol. 2001 Jun;183(11):3417-27. DM3WVPJ RU https://www.ncbi.nlm.nih.gov/pubmed/?term=11344150 DM3WVPJ DI DM3WVPJ DM3WVPJ DN Asacolitin DM3WVPJ MI DEF5JD3 DM3WVPJ MN Arylamine N-acetyltransferase (NAT) DM3WVPJ MT DME DM3WVPJ MA Metabolism DM3WVPJ RN Identification and functional characterization of arylamine N-acetyltransferases in eubacteria: evidence for highly selective acetylation of 5-aminosalicylic acid. J Bacteriol. 2001 Jun;183(11):3417-27. DM3WVPJ RU https://www.ncbi.nlm.nih.gov/pubmed/?term=11344150 DM3WVPJ DI DM3WVPJ DM3WVPJ DN Asacolitin DM3WVPJ MI DE6C3R7 DM3WVPJ MN Arylamine N-acetyltransferase (NAT) DM3WVPJ MT DME DM3WVPJ MA Metabolism DM3WVPJ RN Identification and functional characterization of arylamine N-acetyltransferases in eubacteria: evidence for highly selective acetylation of 5-aminosalicylic acid. J Bacteriol. 2001 Jun;183(11):3417-27. DM3WVPJ RU https://www.ncbi.nlm.nih.gov/pubmed/?term=11344150 DM3WVPJ DI DM3WVPJ DM3WVPJ DN Asacolitin DM3WVPJ MI DE14FI7 DM3WVPJ MN Arylamine N-acetyltransferase (NAT) DM3WVPJ MT DME DM3WVPJ MA Metabolism DM3WVPJ RN Identification and functional characterization of arylamine N-acetyltransferases in eubacteria: evidence for highly selective acetylation of 5-aminosalicylic acid. J Bacteriol. 2001 Jun;183(11):3417-27. DM3WVPJ RU https://www.ncbi.nlm.nih.gov/pubmed/?term=11344150 DM3WVPJ DI DM3WVPJ DM3WVPJ DN Asacolitin DM3WVPJ MI DE8V274 DM3WVPJ MN Arylamine N-acetyltransferase (NAT) DM3WVPJ MT DME DM3WVPJ MA Metabolism DM3WVPJ RN Identification and functional characterization of arylamine N-acetyltransferases in eubacteria: evidence for highly selective acetylation of 5-aminosalicylic acid. J Bacteriol. 2001 Jun;183(11):3417-27. DM3WVPJ RU https://www.ncbi.nlm.nih.gov/pubmed/?term=11344150 DM3WVPJ DI DM3WVPJ DM3WVPJ DN Asacolitin DM3WVPJ MI DEG7L5K DM3WVPJ MN Arylamine N-acetyltransferase (NAT) DM3WVPJ MT DME DM3WVPJ MA Metabolism DM3WVPJ RN Identification and functional characterization of arylamine N-acetyltransferases in eubacteria: evidence for highly selective acetylation of 5-aminosalicylic acid. J Bacteriol. 2001 Jun;183(11):3417-27. DM3WVPJ RU https://www.ncbi.nlm.nih.gov/pubmed/?term=11344150 DM3WVPJ DI DM3WVPJ DM3WVPJ DN Asacolitin DM3WVPJ MI DEJ01UG DM3WVPJ MN Arylamine N-acetyltransferase (NAT) DM3WVPJ MT DME DM3WVPJ MA Metabolism DM3WVPJ RN Identification and functional characterization of arylamine N-acetyltransferases in eubacteria: evidence for highly selective acetylation of 5-aminosalicylic acid. J Bacteriol. 2001 Jun;183(11):3417-27. DM3WVPJ RU https://www.ncbi.nlm.nih.gov/pubmed/?term=11344150 DM3WVPJ DI DM3WVPJ DM3WVPJ DN Asacolitin DM3WVPJ MI DE7OAB3 DM3WVPJ MN N-acetyltransferase 1 (NAT1) DM3WVPJ MT DME DM3WVPJ MA Metabolism DM3WVPJ RN Identification and functional characterization of arylamine N-acetyltransferases in eubacteria: evidence for highly selective acetylation of 5-aminosalicylic acid. J Bacteriol. 2001 Jun;183(11):3417-27. DM3WVPJ RU https://www.ncbi.nlm.nih.gov/pubmed/?term=11344150 DM3WVPJ DI DM3WVPJ DM3WVPJ DN Asacolitin DM3WVPJ MI DER7TA0 DM3WVPJ MN N-acetyltransferase 2 (NAT2) DM3WVPJ MT DME DM3WVPJ MA Metabolism DM3WVPJ RN Identification and functional characterization of arylamine N-acetyltransferases in eubacteria: evidence for highly selective acetylation of 5-aminosalicylic acid. J Bacteriol. 2001 Jun;183(11):3417-27. DM3WVPJ RU https://www.ncbi.nlm.nih.gov/pubmed/?term=11344150 DM5WR0L DI DM5WR0L DM5WR0L DN ASC-201 DM5WR0L MI TTDIGC1 DM5WR0L MN Dipeptidyl peptidase 4 (DPP-4) DM5WR0L MT DTT DM5WR0L MA Inhibitor DM5WR0L RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1612). DM5WR0L RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1612 DMYJ87C DI DMYJ87C DMYJ87C DN ASC-JMX2 DMYJ87C MI TTS64P2 DMYJ87C MN Androgen receptor (AR) DMYJ87C MT DTT DMYJ87C MA Antagonist DMYJ87C RN The ChEMBL database in 2017. Nucleic Acids Res. 2017 Jan 4;45(D1):D945-D954. DMYJ87C RU https://www.ncbi.nlm.nih.gov/pubmed/27899562 DMT5LJN DI DMT5LJN DMT5LJN DN ASC-JMZ1 DMT5LJN MI TTS64P2 DMT5LJN MN Androgen receptor (AR) DMT5LJN MT DTT DMT5LJN MA Modulator DMT5LJN RN The ChEMBL database in 2017. Nucleic Acids Res. 2017 Jan 4;45(D1):D945-D954. DMT5LJN RU https://www.ncbi.nlm.nih.gov/pubmed/27899562 DMT8Y65 DI DMT8Y65 DMT8Y65 DN ASIATIC ACID DMT8Y65 MI TTZHY6R DMT8Y65 MN Glycogen phosphorylase muscle form (GP) DMT8Y65 MT DTT DMT8Y65 MA Inhibitor DMT8Y65 RN Naturally occurring pentacyclic triterpenes as inhibitors of glycogen phosphorylase: synthesis, structure-activity relationships, and X-ray crystal... J Med Chem. 2008 Jun 26;51(12):3540-54. DMT8Y65 RU https://pubmed.ncbi.nlm.nih.gov/18517260 DMTBZUC DI DMTBZUC DMTBZUC DN ASKENDOSIDE B DMTBZUC MI TTULVH8 DMTBZUC MN Tyrosinase (TYR) DMTBZUC MT DTT DMTBZUC MA Inhibitor DMTBZUC RN New tyrosinase inhibitors selected by atomic linear indices-based classification models. Bioorg Med Chem Lett. 2006 Jan 15;16(2):324-30. DMTBZUC RU https://pubmed.ncbi.nlm.nih.gov/16275084 DM2DPYQ DI DM2DPYQ DM2DPYQ DN ASKH95 DM2DPYQ MI TTQR74A DM2DPYQ MN Proteinase activated receptor 2 (PAR2) DM2DPYQ MT DTT DM2DPYQ MA Agonist DM2DPYQ RN Essential role for proteinase-activated receptor-2 in arthritis. J Clin Invest. 2003 Jan;111(1):35-41. DM2DPYQ RU https://pubmed.ncbi.nlm.nih.gov/12511586 DMEO3Y4 DI DMEO3Y4 DMEO3Y4 DN ASN02563583 DMEO3Y4 MI TTMPART DMEO3Y4 MN Uracil nucleotide/cysteinyl leukotriene receptor (GPR17) DMEO3Y4 MT DTT DMEO3Y4 MA Agonist DMEO3Y4 RN In silico identification of new ligands for GPR17: a promising therapeutic target for neurodegenerative diseases. J Comput Aided Mol Des. 2011 Aug;25(8):743-52. DMEO3Y4 RU https://pubmed.ncbi.nlm.nih.gov/21744154 DMC82XN DI DMC82XN DMC82XN DN ASN04421891 DMC82XN MI TTMPART DMC82XN MN Uracil nucleotide/cysteinyl leukotriene receptor (GPR17) DMC82XN MT DTT DMC82XN MA Agonist DMC82XN RN In silico identification of new ligands for GPR17: a promising therapeutic target for neurodegenerative diseases. J Comput Aided Mol Des. 2011 Aug;25(8):743-52. DMC82XN RU https://pubmed.ncbi.nlm.nih.gov/21744154 DMKR69T DI DMKR69T DMKR69T DN ASN04450772 DMKR69T MI TTMPART DMKR69T MN Uracil nucleotide/cysteinyl leukotriene receptor (GPR17) DMKR69T MT DTT DMKR69T MA Agonist DMKR69T RN In silico identification of new ligands for GPR17: a promising therapeutic target for neurodegenerative diseases. J Comput Aided Mol Des. 2011 Aug;25(8):743-52. DMKR69T RU https://pubmed.ncbi.nlm.nih.gov/21744154 DMQ0VZ8 DI DMQ0VZ8 DMQ0VZ8 DN ASN04885796 DMQ0VZ8 MI TTMPART DMQ0VZ8 MN Uracil nucleotide/cysteinyl leukotriene receptor (GPR17) DMQ0VZ8 MT DTT DMQ0VZ8 MA Agonist DMQ0VZ8 RN In silico identification of new ligands for GPR17: a promising therapeutic target for neurodegenerative diseases. J Comput Aided Mol Des. 2011 Aug;25(8):743-52. DMQ0VZ8 RU https://pubmed.ncbi.nlm.nih.gov/21744154 DMA20JP DI DMA20JP DMA20JP DN ASN06917370 DMA20JP MI TTMPART DMA20JP MN Uracil nucleotide/cysteinyl leukotriene receptor (GPR17) DMA20JP MT DTT DMA20JP MA Agonist DMA20JP RN In silico identification of new ligands for GPR17: a promising therapeutic target for neurodegenerative diseases. J Comput Aided Mol Des. 2011 Aug;25(8):743-52. DMA20JP RU https://pubmed.ncbi.nlm.nih.gov/21744154 DMFNZOI DI DMFNZOI DMFNZOI DN ASN-11124542 DMFNZOI MI TTXEZJ4 DMFNZOI MN Tyrosine-protein kinase EIF2AK2 (p68) DMFNZOI MT DTT DMFNZOI MA Inhibitor DMFNZOI RN Small molecule inhibitors of the RNA-dependent protein kinase. Biochem Biophys Res Commun. 2003 Aug 15;308(1):50-7. DMFNZOI RU https://pubmed.ncbi.nlm.nih.gov/12890478 DM8XT1Y DI DM8XT1Y DM8XT1Y DN ASOBAMAST DM8XT1Y MI TTMPGNS DM8XT1Y MN Leukotriene biosynthesis (LT synth) DM8XT1Y MT DTT DM8XT1Y MA Modulator DM8XT1Y RN Regulation of leukotriene biosynthesis. Cancer Metastasis Rev. 1994 Dec;13(3-4):257-67. DM8XT1Y RU https://pubmed.ncbi.nlm.nih.gov/7712588 DM3XCM1 DI DM3XCM1 DM3XCM1 DN ASP-2002 DM3XCM1 MI TT4BT06 DM3XCM1 MN Integrin alpha-4 (ITGA4) DM3XCM1 MT DTT DM3XCM1 MA Antagonist DM3XCM1 RN Asphelia to Present at C21 BioVentures Conference in Napa, CA. 10th Annual C21 BioVentures. May 15, 2008. DM3XCM1 RU http://www.businesswire.com/news/home/20080515005310/en/Asphelia-Present-C21-BioVentures-Conference-Napa-CA#.VhskvPmqpBc DMZ9GQR DI DMZ9GQR DMZ9GQR DN ASP-3258 DMZ9GQR MI TTZ97H5 DMZ9GQR MN Phosphodiesterase 4A (PDE4A) DMZ9GQR MT DTT DMZ9GQR MA Inhibitor DMZ9GQR RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1300). DMZ9GQR RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1300 DMZ9GQR DI DMZ9GQR DMZ9GQR DN ASP-3258 DMZ9GQR MI TTVIAT9 DMZ9GQR MN Phosphodiesterase 4B (PDE4B) DMZ9GQR MT DTT DMZ9GQR MA Inhibitor DMZ9GQR RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1301). DMZ9GQR RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1301 DMZ9GQR DI DMZ9GQR DMZ9GQR DN ASP-3258 DMZ9GQR MI TTSKMI8 DMZ9GQR MN Phosphodiesterase 4D (PDE4D) DMZ9GQR MT DTT DMZ9GQR MA Inhibitor DMZ9GQR RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1303). DMZ9GQR RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1303 DMFWTOP DI DMFWTOP DMFWTOP DN ASP-8370 DMFWTOP MI TTMI6F5 DMFWTOP MN Transient receptor potential cation channel V1 (TRPV1) DMFWTOP MT DTT DMFWTOP MA Antagonist DMFWTOP RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 507). DMFWTOP RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=507 DMGB90V DI DMGB90V DMGB90V DN Aspartate Semialdehyde DMGB90V MI TTQWGU9 DMGB90V MN Bacterial Aspartate-semialdehyde dehydrogenase (Bact asd2) DMGB90V MT DTT DMGB90V MA Inhibitor DMGB90V RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMGB90V RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMK7EYA DI DMK7EYA DMK7EYA DN Aspartic acid DMK7EYA MI DT38SZL DMK7EYA MN Organic cation transporter-like 3 (SLC22A13) DMK7EYA MT DTP DMK7EYA MA Substrate DMK7EYA RN SLC22A13 catalyses unidirectional efflux of aspartate and glutamate at the basolateral membrane of type A intercalated cells in the renal collecting duct. Biochem J. 2014 Jan 15;457(2):243-51. DMK7EYA RU http://www.ncbi.nlm.nih.gov/pubmed/24147638 DMK7EYA DI DMK7EYA DMK7EYA DN Aspartic acid DMK7EYA MI DT2LGOY DMK7EYA MN Putative sodium-coupled neutral amino acid transporter 10 (SLC38A10) DMK7EYA MT DTP DMK7EYA MA Substrate DMK7EYA RN The neuronal and astrocytic protein SLC38A10 transports glutamine, glutamate, and aspartate, suggesting a role in neurotransmission. FEBS Open Bio. 2017 Apr 26;7(6):730-746. DMK7EYA RU http://www.ncbi.nlm.nih.gov/pubmed/28593130 DMJEZ62 DI DMJEZ62 DMJEZ62 DN Asp-BrPmp-Leu DMJEZ62 MI TTUS45N DMJEZ62 MN Leukocyte common antigen (PTPRC) DMJEZ62 MT DTT DMJEZ62 MA Inhibitor DMJEZ62 RN A protected l-bromophosphonomethylphenylalanine amino acid derivative (BrPmp) for synthesis of irreversible protein tyrosine phosphatase inhibitors. Bioorg Med Chem. 2010 Dec 15;18(24):8679-86. DMJEZ62 RU https://pubmed.ncbi.nlm.nih.gov/21055952 DMEW37R DI DMEW37R DMEW37R DN Asp-D-Glu-Leu-Glu-Cha-Cys DMEW37R MI TTWXB3E DMEW37R MN Hepatitis C virus NS3 helicase (HCV NS3) DMEW37R MT DTT DMEW37R MA Inhibitor DMEW37R RN Inhibition of hepatitis C virus NS3 protease activity by product-based peptides is dependent on helicase domain. Bioorg Med Chem Lett. 2001 Jan 22;11(2):203-6. DMEW37R RU https://pubmed.ncbi.nlm.nih.gov/11206459 DMAY2N3 DI DMAY2N3 DMAY2N3 DN Asperlicin DMAY2N3 MI TTCG0AL DMAY2N3 MN Cholecystokinin receptor type A (CCKAR) DMAY2N3 MT DTT DMAY2N3 MA Antagonist DMAY2N3 RN Privileged structures: a useful concept for the rational design of new lead drug candidates. Mini Rev Med Chem. 2007 Nov;7(11):1108-19. DMAY2N3 RU https://pubmed.ncbi.nlm.nih.gov/18045214 DMLBSNP DI DMLBSNP DMLBSNP DN aspirin triggered lipoxin A4 DMLBSNP MI TTOJ1NF DMLBSNP MN FMLP-related receptor I (FPR2) DMLBSNP MT DTT DMLBSNP MA Agonist DMLBSNP RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 223). DMLBSNP RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=223 DMOP941 DI DMOP941 DMOP941 DN aspirin-triggered resolvin D1 DMOP941 MI TTOJ1NF DMOP941 MN FMLP-related receptor I (FPR2) DMOP941 MT DTT DMOP941 MA Agonist DMOP941 RN Resolvin D1 receptor stereoselectivity and regulation of inflammation and proresolving microRNAs. Am J Pathol. 2012 May;180(5):2018-27. DMOP941 RU https://pubmed.ncbi.nlm.nih.gov/22449948 DMOP941 DI DMOP941 DMOP941 DN aspirin-triggered resolvin D1 DMOP941 MI TT946IA DMOP941 MN Transient receptor potential cation channel V3 (TRPV3) DMOP941 MT DTT DMOP941 MA Blocker (channel blocker) DMOP941 RN 17(R)-resolvin D1 specifically inhibits transient receptor potential ion channel vanilloid 3 leading to peripheral antinociception. Br J Pharmacol. 2012 Feb;165(3):683-92. DMOP941 RU https://pubmed.ncbi.nlm.nih.gov/21718307 DMKAHYQ DI DMKAHYQ DMKAHYQ DN Asp-Tyr(OSO3H)-Met-Gly-Trp-Met-Asp-Phe DMKAHYQ MI TTCG0AL DMKAHYQ MN Cholecystokinin receptor type A (CCKAR) DMKAHYQ MT DTT DMKAHYQ MA Inhibitor DMKAHYQ RN Toward developing peptidomimetics: Successful replacement of backbone amide bonds in tetrapeptide-based CCK-A receptor agonists, Bioorg. Med. Chem. Lett. 3(5):855-860 (1993). DMKAHYQ RU http://www.sciencedirect.com/science/article/pii/S0960894X00806800 DMKAHYQ DI DMKAHYQ DMKAHYQ DN Asp-Tyr(OSO3H)-Met-Gly-Trp-Met-Asp-Phe DMKAHYQ MI TTVFO0U DMKAHYQ MN Gastrin/cholecystokinin type B receptor (CCKBR) DMKAHYQ MT DTT DMKAHYQ MA Inhibitor DMKAHYQ RN The rational design and synthesis of non-peptide hegnylogues of CCK-26-33 - a novel series of CCK-A selective ligands, Bioorg. Med. Chem. Lett. 3(5):889-894 (1993). DMKAHYQ RU http://www.sciencedirect.com/science/article/pii/S0960894X00806873 DME76KU DI DME76KU DME76KU DN AST-487 DME76KU MI TTGJCWZ DME76KU MN Fms-like tyrosine kinase 3 (FLT-3) DME76KU MT DTT DME76KU MA Inhibitor DME76KU RN Comprehensive analysis of kinase inhibitor selectivity. Nat Biotechnol. 2011 Oct 30;29(11):1046-51. DME76KU RU https://pubmed.ncbi.nlm.nih.gov/22037378 DME76KU DI DME76KU DME76KU DN AST-487 DME76KU MI TT4DXQT DME76KU MN Proto-oncogene c-Ret (RET) DME76KU MT DTT DME76KU MA Inhibitor DME76KU RN The RET kinase inhibitor NVP-AST487 blocks growth and calcitonin gene expression through distinct mechanisms in medullary thyroid cancer cells. Cancer Res. 2007 Jul 15;67(14):6956-64. DME76KU RU https://pubmed.ncbi.nlm.nih.gov/17638907 DME76KU DI DME76KU DME76KU DN AST-487 DME76KU MI TTX41N9 DME76KU MN Tyrosine-protein kinase Kit (KIT) DME76KU MT DTT DME76KU MA Inhibitor DME76KU RN The RET kinase inhibitor NVP-AST487 blocks growth and calcitonin gene expression through distinct mechanisms in medullary thyroid cancer cells. Cancer Res. 2007 Jul 15;67(14):6956-64. DME76KU RU https://pubmed.ncbi.nlm.nih.gov/17638907 DME76KU DI DME76KU DME76KU DN AST-487 DME76KU MI TTUTJGQ DME76KU MN Vascular endothelial growth factor receptor 2 (KDR) DME76KU MT DTT DME76KU MA Inhibitor DME76KU RN The RET kinase inhibitor NVP-AST487 blocks growth and calcitonin gene expression through distinct mechanisms in medullary thyroid cancer cells. Cancer Res. 2007 Jul 15;67(14):6956-64. DME76KU RU https://pubmed.ncbi.nlm.nih.gov/17638907 DMJAPFH DI DMJAPFH DMJAPFH DN Asterric acid DMJAPFH MI TTKRD0G DMJAPFH MN Endothelin A receptor (EDNRA) DMJAPFH MT DTT DMJAPFH MA Inhibitor DMJAPFH RN New chlorinated diphenyl ethers from an Aspergillus species. J Nat Prod. 2002 Jan;65(1):7-10. DMJAPFH RU https://pubmed.ncbi.nlm.nih.gov/11809055 DMZHWPG DI DMZHWPG DMZHWPG DN ASTRAGALIN DMZHWPG MI TTFBNVI DMZHWPG MN Aldose reductase (AKR1B1) DMZHWPG MT DTT DMZHWPG MA Inhibitor DMZHWPG RN Erigeroflavanone, a flavanone derivative from the flowers of Erigeron annuus with protein glycation and aldose reductase inhibitory activity. J Nat Prod. 2008 Apr;71(4):713-5. DMZHWPG RU https://pubmed.ncbi.nlm.nih.gov/18298080 DMZHWPG DI DMZHWPG DMZHWPG DN ASTRAGALIN DMZHWPG MI TTL69WB DMZHWPG MN Angiotensin-converting enzyme (ACE) DMZHWPG MT DTT DMZHWPG MA Inhibitor DMZHWPG RN Inhibitory effects of various flavonoids isolated from leaves of persimmon on angiotensin-converting enzyme activity. J Nat Prod. 1987 Jul-Aug;50(4):680-3. DMZHWPG RU https://pubmed.ncbi.nlm.nih.gov/3430165 DMSFLTK DI DMSFLTK DMSFLTK DN astressin DMSFLTK MI TTIY658 DMSFLTK MN Corticotropin-releasing factor receptor 2 (CRHR2) DMSFLTK MT DTT DMSFLTK MA Antagonist DMSFLTK RN Comparison of an agonist, urocortin, and an antagonist, astressin, as radioligands for characterization of corticotropin-releasing factor receptors. J Pharmacol Exp Ther. 1999 Feb;288(2):729-34. DMSFLTK RU https://pubmed.ncbi.nlm.nih.gov/9918582 DMODLPS DI DMODLPS DMODLPS DN AT-008 DMODLPS MI TT7HQD0 DMODLPS MN C-C chemokine receptor type 4 (CCR4) DMODLPS MT DTT DMODLPS MA Antagonist DMODLPS RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 61). DMODLPS RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=61 DMCO2S4 DI DMCO2S4 DMCO2S4 DN AT-009 DMCO2S4 MI TTBID49 DMCO2S4 MN C-X-C chemokine receptor type 4 (CXCR4) DMCO2S4 MT DTT DMCO2S4 MA Antagonist DMCO2S4 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 71). DMCO2S4 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=71 DMJNQ5G DI DMJNQ5G DMJNQ5G DN ATC0065 DMJNQ5G MI TTX4RTB DMJNQ5G MN Melanin-concentrating hormone receptor 1 (MCHR1) DMJNQ5G MT DTT DMJNQ5G MA Antagonist DMJNQ5G RN Anxiolytic- and antidepressant-like profile of ATC0065 and ATC0175: nonpeptidic and orally active melanin-concentrating hormone receptor 1 antagoni... J Pharmacol Exp Ther. 2005 May;313(2):831-9. DMJNQ5G RU https://pubmed.ncbi.nlm.nih.gov/15677346 DMJNQ5G DI DMJNQ5G DMJNQ5G DN ATC0065 DMJNQ5G MI TTS17MG DMJNQ5G MN Melanin-concentrating hormone receptor 2 (MCHR2) DMJNQ5G MT DTT DMJNQ5G MA Antagonist DMJNQ5G RN Anxiolytic- and antidepressant-like profile of ATC0065 and ATC0175: nonpeptidic and orally active melanin-concentrating hormone receptor 1 antagoni... J Pharmacol Exp Ther. 2005 May;313(2):831-9. DMJNQ5G RU https://pubmed.ncbi.nlm.nih.gov/15677346 DMIA2F1 DI DMIA2F1 DMIA2F1 DN ATC-120 DMIA2F1 MI TTMI6F5 DMIA2F1 MN Transient receptor potential cation channel V1 (TRPV1) DMIA2F1 MT DTT DMIA2F1 MA Inhibitor DMIA2F1 RN Silicon switch approach in TRPV1 antagonist MK-056 and its analogues. Bioorg Med Chem. 2010 Jan 1;18(1):111-6. DMIA2F1 RU https://pubmed.ncbi.nlm.nih.gov/19931463 DMPJRHX DI DMPJRHX DMPJRHX DN ATF-HI-8 DMPJRHX MI TT2WR1T DMPJRHX MN Cationic trypsinogen (PRSS1) DMPJRHX MT DTT DMPJRHX MA Modulator DMPJRHX RN Inhibitory effect of a conjugate between human urokinase and urinary trypsin inhibitor on tumor cell invasion in vitro. J Biol Chem. 1995 Apr 7;270(14):8361-6. DMPJRHX RU https://www.ncbi.nlm.nih.gov/pubmed/7713945 DMPJRHX DI DMPJRHX DMPJRHX DN ATF-HI-8 DMPJRHX MI TTGY7WI DMPJRHX MN Urokinase-type plasminogen activator (PLAU) DMPJRHX MT DTT DMPJRHX MA Modulator DMPJRHX RN Inhibitory effect of a conjugate between human urokinase and urinary trypsin inhibitor on tumor cell invasion in vitro. J Biol Chem. 1995 Apr 7;270(14):8361-6. DMPJRHX RU https://www.ncbi.nlm.nih.gov/pubmed/7713945 DMSNBMQ DI DMSNBMQ DMSNBMQ DN ATH-90879 DMSNBMQ MI TT9JNIC DMSNBMQ MN Histamine H3 receptor (H3R) DMSNBMQ MT DTT DMSNBMQ MA Antagonist DMSNBMQ RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 264). DMSNBMQ RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=264 DMN5VDB DI DMN5VDB DMN5VDB DN ATI-1150 DMN5VDB MI TTGTQHC DMN5VDB MN DNA topoisomerase I (TOP1) DMN5VDB MT DTT DMN5VDB MA Inhibitor DMN5VDB RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2636). DMN5VDB RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2636 DMLDWHP DI DMLDWHP DMLDWHP DN ATI-2341 DMLDWHP MI TTBID49 DMLDWHP MN C-X-C chemokine receptor type 4 (CXCR4) DMLDWHP MT DTT DMLDWHP MA Agonist DMLDWHP RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 71). DMLDWHP RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=71 DMAZ0EQ DI DMAZ0EQ DMAZ0EQ DN ATL-801 DMAZ0EQ MI TTNE7KG DMAZ0EQ MN Adenosine A2b receptor (ADORA2B) DMAZ0EQ MT DTT DMAZ0EQ MA Antagonist DMAZ0EQ RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 20). DMAZ0EQ RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=20 DMYMCQA DI DMYMCQA DMYMCQA DN ATL802 DMYMCQA MI TTK25J1 DMYMCQA MN Adenosine A1 receptor (ADORA1) DMYMCQA MT DTT DMYMCQA MA Antagonist DMYMCQA RN Anilide derivatives of an 8-phenylxanthine carboxylic congener are highly potent and selective antagonists at human A(2B) adenosine receptors. J Med Chem. 2000 Mar 23;43(6):1165-72. DMYMCQA RU https://pubmed.ncbi.nlm.nih.gov/10737749 DMYMCQA DI DMYMCQA DMYMCQA DN ATL802 DMYMCQA MI TTNE7KG DMYMCQA MN Adenosine A2b receptor (ADORA2B) DMYMCQA MT DTT DMYMCQA MA Antagonist DMYMCQA RN Anilide derivatives of an 8-phenylxanthine carboxylic congener are highly potent and selective antagonists at human A(2B) adenosine receptors. J Med Chem. 2000 Mar 23;43(6):1165-72. DMYMCQA RU https://pubmed.ncbi.nlm.nih.gov/10737749 DMYMCQA DI DMYMCQA DMYMCQA DN ATL802 DMYMCQA MI TTJFY5U DMYMCQA MN Adenosine A3 receptor (ADORA3) DMYMCQA MT DTT DMYMCQA MA Antagonist DMYMCQA RN Anilide derivatives of an 8-phenylxanthine carboxylic congener are highly potent and selective antagonists at human A(2B) adenosine receptors. J Med Chem. 2000 Mar 23;43(6):1165-72. DMYMCQA RU https://pubmed.ncbi.nlm.nih.gov/10737749 DM6V9SC DI DM6V9SC DM6V9SC DN ATL-844 DM6V9SC MI TTNE7KG DM6V9SC MN Adenosine A2b receptor (ADORA2B) DM6V9SC MT DTT DM6V9SC MA Antagonist DM6V9SC RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 20). DM6V9SC RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=20 DMA632U DI DMA632U DMA632U DN ATLa2 DMA632U MI TTOJ1NF DMA632U MN FMLP-related receptor I (FPR2) DMA632U MT DTT DMA632U MA Agonist DMA632U RN Novel 3-oxa lipoxin A4 analogues with enhanced chemical and metabolic stability have anti-inflammatory activity in vivo. J Med Chem. 2004 Apr 8;47(8):2157-65. DMA632U RU https://pubmed.ncbi.nlm.nih.gov/15056011 DMR2M7L DI DMR2M7L DMR2M7L DN ATN-658 DMR2M7L MI TTGY7WI DMR2M7L MN Urokinase-type plasminogen activator (PLAU) DMR2M7L MT DTT DMR2M7L MA Activator DMR2M7L RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2393). DMR2M7L RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2393 DM2DAFS DI DM2DAFS DM2DAFS DN ATPA DM2DAFS MI TT0MYE2 DM2DAFS MN Glutamate receptor ionotropic kainate 1 (GRIK1) DM2DAFS MT DTT DM2DAFS MA Agonist DM2DAFS RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 450). DM2DAFS RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=450 DMXHQIN DI DMXHQIN DMXHQIN DN ATPgammaS DMXHQIN MI TTA93TL DMXHQIN MN P2Y purinoceptor 1 (P2RY1) DMXHQIN MT DTT DMXHQIN MA Agonist DMXHQIN RN An examination of deoxyadenosine 5'(alpha-thio)triphosphate as a ligand to define P2Y receptors and its selectivity as a low potency partial agonist of the P2Y1 receptor. Br J Pharmacol. 1997 May;121(2):338-44. DMXHQIN RU https://pubmed.ncbi.nlm.nih.gov/9154346 DMXHQIN DI DMXHQIN DMXHQIN DN ATPgammaS DMXHQIN MI TTYXPCO DMXHQIN MN P2Y purinoceptor 11 (P2RY11) DMXHQIN MT DTT DMXHQIN MA Agonist DMXHQIN RN Pharmacological characterization of the human P2Y11 receptor. Br J Pharmacol. 1999 Nov;128(6):1199-206. DMXHQIN RU https://pubmed.ncbi.nlm.nih.gov/10578132 DMXHQIN DI DMXHQIN DMXHQIN DN ATPgammaS DMXHQIN MI TT1FE3L DMXHQIN MN P2Y purinoceptor 13 (P2RY13) DMXHQIN MT DTT DMXHQIN MA Agonist DMXHQIN RN Pharmacological characterization of the human P2Y13 receptor. Mol Pharmacol. 2003 Jul;64(1):104-12. DMXHQIN RU https://pubmed.ncbi.nlm.nih.gov/12815166 DMXLS78 DI DMXLS78 DMXLS78 DN ATPO DMXLS78 MI TTVPQTF DMXLS78 MN Glutamate receptor AMPA 1 (GRIA1) DMXLS78 MT DTT DMXLS78 MA Antagonist DMXLS78 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 444). DMXLS78 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=444 DMXLS78 DI DMXLS78 DMXLS78 DN ATPO DMXLS78 MI TT9HLZ0 DMXLS78 MN Glutamate receptor AMPA 2 (GRIA2) DMXLS78 MT DTT DMXLS78 MA Antagonist DMXLS78 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 445). DMXLS78 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=445 DMXLS78 DI DMXLS78 DMXLS78 DN ATPO DMXLS78 MI TT82EZV DMXLS78 MN Glutamate receptor AMPA 3 (GRIA3) DMXLS78 MT DTT DMXLS78 MA Antagonist DMXLS78 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 446). DMXLS78 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=446 DMXLS78 DI DMXLS78 DMXLS78 DN ATPO DMXLS78 MI TTPJR0G DMXLS78 MN Glutamate receptor AMPA 4 (GRIA4) DMXLS78 MT DTT DMXLS78 MA Antagonist DMXLS78 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 447). DMXLS78 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=447 DML2MAI DI DML2MAI DML2MAI DN ATRIPLICIOLIDTIGLATE DML2MAI MI TTSXVID DML2MAI MN Nuclear factor NF-kappa-B (NFKB) DML2MAI MT DTT DML2MAI MA Inhibitor DML2MAI RN Quantitative structure-activity relationship of sesquiterpene lactones as inhibitors of the transcription factor NF-kappaB. J Med Chem. 2004 Nov 18;47(24):6042-54. DML2MAI RU https://pubmed.ncbi.nlm.nih.gov/15537359 DML3R5Z DI DML3R5Z DML3R5Z DN Atropisomer 1 DML3R5Z MI TTRMX3V DML3R5Z MN Janus kinase 2 (JAK-2) DML3R5Z MT DTT DML3R5Z MA Inhibitor DML3R5Z RN Janus kinase 2 inhibitors. Synthesis and characterization of a novel polycyclic azaindole. J Med Chem. 2009 Dec 24;52(24):7938-41. DML3R5Z RU https://pubmed.ncbi.nlm.nih.gov/20014869 DML3R5Z DI DML3R5Z DML3R5Z DN Atropisomer 1 DML3R5Z MI TTT7PJU DML3R5Z MN Janus kinase 3 (JAK-3) DML3R5Z MT DTT DML3R5Z MA Inhibitor DML3R5Z RN Janus kinase 2 inhibitors. Synthesis and characterization of a novel polycyclic azaindole. J Med Chem. 2009 Dec 24;52(24):7938-41. DML3R5Z RU https://pubmed.ncbi.nlm.nih.gov/20014869 DMHEK4U DI DMHEK4U DMHEK4U DN ATS-907 DMHEK4U MI TTZN7RP DMHEK4U MN Rho-associated protein kinase 1 (ROCK1) DMHEK4U MT DTT DMHEK4U MA Inhibitor DMHEK4U RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1503). DMHEK4U RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1503 DMHEK4U DI DMHEK4U DMHEK4U DN ATS-907 DMHEK4U MI TTGWKQJ DMHEK4U MN Rho-associated protein kinase 2 (ROCK2) DMHEK4U MT DTT DMHEK4U MA Inhibitor DMHEK4U RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1504). DMHEK4U RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1504 DMKVDAN DI DMKVDAN DMKVDAN DN Augustic acid DMKVDAN MI TTELIN2 DMKVDAN MN PTPN1 messenger RNA (PTPN1 mRNA) DMKVDAN MT DTT DMKVDAN MA Inhibitor DMKVDAN RN Synthesis and biological evaluation of heterocyclic ring-substituted maslinic acid derivatives as novel inhibitors of protein tyrosine phosphatase 1B. Bioorg Med Chem Lett. 2009 Dec 1;19(23):6618-22. DMKVDAN RU https://pubmed.ncbi.nlm.nih.gov/19846303 DMZNUDT DI DMZNUDT DMZNUDT DN Aurachin DMZNUDT MI DE1OW2F DMZNUDT MN Cytochrome P450 RauA (rauA) DMZNUDT MT DME DMZNUDT MA Metabolism DMZNUDT RN nan DMZNUDT RU nan DMDKH8N DI DMDKH8N DMDKH8N DN AURASPERONE A DMDKH8N MI TTQY2EJ DMDKH8N MN TERT messenger RNA (TERT mRNA) DMDKH8N MT DTT DMDKH8N MA Inhibitor DMDKH8N RN New dimeric naphthopyrones from Aspergillus niger. J Nat Prod. 2003 Jan;66(1):136-9. DMDKH8N RU https://pubmed.ncbi.nlm.nih.gov/12542363 DMOIQ4K DI DMOIQ4K DMOIQ4K DN Auryntricarboxylic acid (ATA) DMOIQ4K MI TT3SZBT DMOIQ4K MN von Willebrand factor (VWF) DMOIQ4K MT DTT DMOIQ4K MA Inhibitor DMOIQ4K RN Novel approaches to the treatment of thrombosis. Trends Pharmacol Sci. 2002 Jan;23(1):25-32. DMOIQ4K RU https://pubmed.ncbi.nlm.nih.gov/11804648 DMFS4RD DI DMFS4RD DMFS4RD DN Autoantibody LKM-3 DMFS4RD MI TTO69J7 DMFS4RD MN UDP-glucuronosyltransferase 2B7 (UGT2B7) DMFS4RD MT DTT DMFS4RD MA Inhibitor DMFS4RD RN Characterization of autoantibodies against uridine-diphosphate glucuronosyltransferase in patients with inflammatory liver diseases. Hepatology. 2001 May;33(5):1053-9. DMFS4RD RU https://pubmed.ncbi.nlm.nih.gov/11343231 DMVGIO5 DI DMVGIO5 DMVGIO5 DN AUY954 DMVGIO5 MI TT9JZCK DMVGIO5 MN Sphingosine-1-phosphate receptor 1 (S1PR1) DMVGIO5 MT DTT DMVGIO5 MA Agonist DMVGIO5 RN A monoselective sphingosine-1-phosphate receptor-1 agonist prevents allograft rejection in a stringent rat heart transplantation model. Chem Biol. 2006 Nov;13(11):1227-34. DMVGIO5 RU https://pubmed.ncbi.nlm.nih.gov/17114004 DMVGIO5 DI DMVGIO5 DMVGIO5 DN AUY954 DMVGIO5 MI TTVSMOH DMVGIO5 MN Sphingosine-1-phosphate receptor 2 (S1PR2) DMVGIO5 MT DTT DMVGIO5 MA Agonist DMVGIO5 RN A monoselective sphingosine-1-phosphate receptor-1 agonist prevents allograft rejection in a stringent rat heart transplantation model. Chem Biol. 2006 Nov;13(11):1227-34. DMVGIO5 RU https://pubmed.ncbi.nlm.nih.gov/17114004 DMVGIO5 DI DMVGIO5 DMVGIO5 DN AUY954 DMVGIO5 MI TTDYP7I DMVGIO5 MN Sphingosine-1-phosphate receptor 3 (S1PR3) DMVGIO5 MT DTT DMVGIO5 MA Agonist DMVGIO5 RN Synthesis and biological evaluation of gamma-aminophosphonates as potent, subtype-selective sphingosine 1-phosphate receptor agonists and antagonists. Bioorg Med Chem. 2007 Jan 15;15(2):663-77. DMVGIO5 RU https://pubmed.ncbi.nlm.nih.gov/17113298 DMVGIO5 DI DMVGIO5 DMVGIO5 DN AUY954 DMVGIO5 MI TTZ8C5Q DMVGIO5 MN Sphingosine-1-phosphate receptor 4 (S1PR4) DMVGIO5 MT DTT DMVGIO5 MA Agonist DMVGIO5 RN A monoselective sphingosine-1-phosphate receptor-1 agonist prevents allograft rejection in a stringent rat heart transplantation model. Chem Biol. 2006 Nov;13(11):1227-34. DMVGIO5 RU https://pubmed.ncbi.nlm.nih.gov/17114004 DMVGIO5 DI DMVGIO5 DMVGIO5 DN AUY954 DMVGIO5 MI TTDZCKV DMVGIO5 MN Sphingosine-1-phosphate receptor 5 (S1PR5) DMVGIO5 MT DTT DMVGIO5 MA Agonist DMVGIO5 RN A monoselective sphingosine-1-phosphate receptor-1 agonist prevents allograft rejection in a stringent rat heart transplantation model. Chem Biol. 2006 Nov;13(11):1227-34. DMVGIO5 RU https://pubmed.ncbi.nlm.nih.gov/17114004 DMF1VS9 DI DMF1VS9 DMF1VS9 DN AV-370 DMF1VS9 MI TTST7KB DMF1VS9 MN Fibroblast growth factor receptor 3 (FGFR3) DMF1VS9 MT DTT DMF1VS9 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1810). DMF1VS9 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1810 DM9R3WT DI DM9R3WT DM9R3WT DN AVE 0991 DM9R3WT MI TTOISYB DM9R3WT MN Proto-oncogene Mas (MAS) DM9R3WT MT DTT DM9R3WT MA Agonist DM9R3WT RN Nonpeptide AVE 0991 is an angiotensin-(1-7) receptor Mas agonist in the mouse kidney. Hypertension. 2004 Oct;44(4):490-6. DM9R3WT RU https://pubmed.ncbi.nlm.nih.gov/15326087 DMC0PY5 DI DMC0PY5 DMC0PY5 DN AVE-1876 DMC0PY5 MI TTDCVZW DMC0PY5 MN Gamma-aminobutyric acid B receptor (GABBR) DMC0PY5 MT DTT DMC0PY5 MA Modulator DMC0PY5 RN Company report (Sanofi) DMC0PY5 RU http://en.sanofi.com/Images/16068_AR_2004_EN.pdf DMDTONZ DI DMDTONZ DMDTONZ DN AVP-13546 DMDTONZ MI TT2AST1 DMDTONZ MN Macrophage migration inhibitory factor (MIF) DMDTONZ MT DTT DMDTONZ MA Inhibitor DMDTONZ RN MIF in autoimmunity and novel therapeutic approaches. Autoimmun Rev. 2009 Jan;8(3):244-9. DMDTONZ RU https://pubmed.ncbi.nlm.nih.gov/18721909 DMBNDYK DI DMBNDYK DMBNDYK DN AVP-13748 DMBNDYK MI TT2AST1 DMBNDYK MN Macrophage migration inhibitory factor (MIF) DMBNDYK MT DTT DMBNDYK MA Inhibitor DMBNDYK RN MIF in autoimmunity and novel therapeutic approaches. Autoimmun Rev. 2009 Jan;8(3):244-9. DMBNDYK RU https://pubmed.ncbi.nlm.nih.gov/18721909 DMNQ9R4 DI DMNQ9R4 DMNQ9R4 DN AVPIAQKSEK-FAM DMNQ9R4 MI TTK3WBU DMNQ9R4 MN XIAP messenger RNA (XIAP mRNA) DMNQ9R4 MT DTT DMNQ9R4 MA Inhibitor DMNQ9R4 RN Discovery of embelin as a cell-permeable, small-molecular weight inhibitor of XIAP through structure-based computational screening of a traditional... J Med Chem. 2004 May 6;47(10):2430-40. DMNQ9R4 RU https://pubmed.ncbi.nlm.nih.gov/15115387 DMK9BMQ DI DMK9BMQ DMK9BMQ DN AVVYPWT DMK9BMQ MI TT2THBD DMK9BMQ MN P2X purinoceptor 3 (P2RX3) DMK9BMQ MT DTT DMK9BMQ MA Inhibitor DMK9BMQ RN Structure-activity relationship studies of spinorphin as a potent and selective human P2X(3) receptor antagonist. J Med Chem. 2007 Sep 6;50(18):4543-7. DMK9BMQ RU https://pubmed.ncbi.nlm.nih.gov/17676725 DMG6LJ8 DI DMG6LJ8 DMG6LJ8 DN AW-00430 DMG6LJ8 MI TTG5QB7 DMG6LJ8 MN Calpain-2 (CAPN2) DMG6LJ8 MT DTT DMG6LJ8 MA Inhibitor DMG6LJ8 RN In silico identification and biochemical evaluation of novel inhibitors of NRH:quinone oxidoreductase 2 (NQO2). Bioorg Med Chem Lett. 2010 Dec 15;20(24):7331-6. DMG6LJ8 RU https://pubmed.ncbi.nlm.nih.gov/21074425 DMIWMJP DI DMIWMJP DMIWMJP DN AwFwLL-NH2 DMIWMJP MI TTWDC17 DMIWMJP MN Growth hormone secretagogue receptor 1 (GHSR) DMIWMJP MT DTT DMIWMJP MA Inhibitor DMIWMJP RN Identification of an efficacy switch region in the ghrelin receptor responsible for interchange between agonism and inverse agonism. J Biol Chem. 2007 May 25;282(21):15799-811. DMIWMJP RU https://pubmed.ncbi.nlm.nih.gov/17371869 DMDWCY7 DI DMDWCY7 DMDWCY7 DN AX-006 DMDWCY7 MI TTT1JVS DMDWCY7 MN Cytosolic phospholipase A2 (GIVA cPLA2) DMDWCY7 MT DTT DMDWCY7 MA Inhibitor DMDWCY7 RN 2-Oxoamide inhibitors of phospholipase A2 activity and cellular arachidonate release based on dipeptides and pseudodipeptides. Bioorg Med Chem. 2009 Jul 1;17(13):4833-43. DMDWCY7 RU https://pubmed.ncbi.nlm.nih.gov/19443224 DMIDXSN DI DMIDXSN DMIDXSN DN AX-048 DMIDXSN MI TTT1JVS DMIDXSN MN Cytosolic phospholipase A2 (GIVA cPLA2) DMIDXSN MT DTT DMIDXSN MA Inhibitor DMIDXSN RN 2-Oxoamide inhibitors of phospholipase A2 activity and cellular arachidonate release based on dipeptides and pseudodipeptides. Bioorg Med Chem. 2009 Jul 1;17(13):4833-43. DMIDXSN RU https://pubmed.ncbi.nlm.nih.gov/19443224 DMKCT0M DI DMKCT0M DMKCT0M DN AX-9657 DMKCT0M MI TTPLTSQ DMKCT0M MN Neutrophil elastase (NE) DMKCT0M MT DTT DMKCT0M MA Inhibitor DMKCT0M RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2358). DMKCT0M RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2358 DMT5P8O DI DMT5P8O DMT5P8O DN Axogenesis Factor-1 DMT5P8O MI TTEDJN4 DMT5P8O MN Low-affinity nerve growth factor receptor (NGFR) DMT5P8O MT DTT DMT5P8O MA Modulator DMT5P8O RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1888). DMT5P8O RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1888 DMNO6PL DI DMNO6PL DMNO6PL DN AZ10417808 DMNO6PL MI TTPF2QI DMNO6PL MN Caspase-3 (CASP3) DMNO6PL MT DTT DMNO6PL MA Inhibitor DMNO6PL RN Novel small molecule inhibitors of caspase-3 block cellular and biochemical features of apoptosis. J Pharmacol Exp Ther. 2003 Jan;304(1):433-40. DMNO6PL RU https://pubmed.ncbi.nlm.nih.gov/12490620 DMDRXCP DI DMDRXCP DMDRXCP DN AZ11645373 DMDRXCP MI TT473XN DMDRXCP MN P2X purinoceptor 7 (P2RX7) DMDRXCP MT DTT DMDRXCP MA Modulator (allosteric modulator) DMDRXCP RN Mechanism of action of species-selective P2X(7) receptor antagonists. Br J Pharmacol. 2009 Apr;156(8):1312-25. DMDRXCP RU https://pubmed.ncbi.nlm.nih.gov/19309360 DMRUA0Y DI DMRUA0Y DMRUA0Y DN AZ-11657312 DMRUA0Y MI TT473XN DMRUA0Y MN P2X purinoceptor 7 (P2RX7) DMRUA0Y MT DTT DMRUA0Y MA Antagonist DMRUA0Y RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 484). DMRUA0Y RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=484 DMVX8LO DI DMVX8LO DMVX8LO DN AZ11657312 (salt free) DMVX8LO MI TT473XN DMVX8LO MN P2X purinoceptor 7 (P2RX7) DMVX8LO MT DTT DMVX8LO MA Antagonist DMVX8LO RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 484). DMVX8LO RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=484 DM1IN35 DI DM1IN35 DM1IN35 DN AZ12216052 DM1IN35 MI TT0IFKL DM1IN35 MN Metabotropic glutamate receptor 8 (mGluR8) DM1IN35 MT DTT DM1IN35 MA Modulator (allosteric modulator) DM1IN35 RN Acute pharmacological modulation of mGluR8 reduces measures of anxiety. Behav Brain Res. 2010 Oct 15;212(2):168-73. DM1IN35 RU https://pubmed.ncbi.nlm.nih.gov/20385173 DMQ5H2V DI DMQ5H2V DMQ5H2V DN AZ12260493 DMQ5H2V MI TTECBXN DMQ5H2V MN Oxysterols receptor LXR-alpha (NR1H3) DMQ5H2V MT DTT DMQ5H2V MA Agonist DMQ5H2V RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 602). DMQ5H2V RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=602 DMQ5H2V DI DMQ5H2V DMQ5H2V DN AZ12260493 DMQ5H2V MI TTXA6PH DMQ5H2V MN Oxysterols receptor LXR-beta (NR1H2) DMQ5H2V MT DTT DMQ5H2V MA Agonist DMQ5H2V RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 601). DMQ5H2V RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=601 DMYDWH1 DI DMYDWH1 DMYDWH1 DN AZ13483342 DMYDWH1 MI TTX4RTB DMYDWH1 MN Melanin-concentrating hormone receptor 1 (MCHR1) DMYDWH1 MT DTT DMYDWH1 MA Antagonist DMYDWH1 RN Discovery of cyclopentane- and cyclohexane-trans-1,3-diamines as potent melanin-concentrating hormone receptor 1 antagonists. Bioorg Med Chem Lett. 2007 Aug 1;17(15):4232-41. DMYDWH1 RU https://pubmed.ncbi.nlm.nih.gov/17532215 DMNQ3HV DI DMNQ3HV DMNQ3HV DN AZ20 DMNQ3HV MI TT8ZYBQ DMNQ3HV MN Serine/threonine-protein kinase ATR (FRP1) DMNQ3HV MT DTT DMNQ3HV MA Inhibitor DMNQ3HV RN Discovery of 4-{4-[(3R)-3-Methylmorpholin-4-yl]-6-[1-(methylsulfonyl)cyclopropyl]pyrimidin-2-yl}-1H-indole (AZ20): a potent and selective inhibitor of ATR protein kinase with monotherapy in vivo antitumor activity. J Med Chem. 2013 Mar 14;56(5):2125-38. DMNQ3HV RU https://pubmed.ncbi.nlm.nih.gov/23394205 DMVMW9S DI DMVMW9S DMVMW9S DN AZ3971 DMVMW9S MI TT8JRS7 DMVMW9S MN Beta-secretase (BACE) DMVMW9S MT DTT DMVMW9S MA Inhibitor DMVMW9S RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2330). DMVMW9S RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2330 DMATC5P DI DMATC5P DMATC5P DN AZ4800 DMATC5P MI TTE4KHA DMATC5P MN Amyloid beta A4 protein (APP) DMATC5P MT DTT DMATC5P MA Inhibitor DMATC5P RN First and second generation gamma-secretase modulators (GSMs) modulate amyloid-beta (Abeta) peptide production through different mechanisms. J Biol Chem. 2012 Apr 6;287(15):11810-9. DMATC5P RU https://pubmed.ncbi.nlm.nih.gov/22334705 DM1XE4F DI DM1XE4F DM1XE4F DN AZ-599 DM1XE4F MI TT6OEDT DM1XE4F MN Cannabinoid receptor 1 (CB1) DM1XE4F MT DTT DM1XE4F MA Agonist DM1XE4F RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 56). DM1XE4F RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=56 DMEWQHP DI DMEWQHP DMEWQHP DN AZ-628 DMEWQHP MI TTWCGQT DMEWQHP MN Serine/threonine-protein kinase B-raf (BRAF) DMEWQHP MT DTT DMEWQHP MA Inhibitor DMEWQHP RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 8475). DMEWQHP RU http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=8475 DM95Y82 DI DM95Y82 DM95Y82 DN AZ960 DM95Y82 MI TTRMX3V DM95Y82 MN Janus kinase 2 (JAK-2) DM95Y82 MT DTT DM95Y82 MA Inhibitor DM95Y82 RN Effects of the JAK2 inhibitor, AZ960, on Pim/BAD/BCL-xL survival signaling in the human JAK2 V617F cell line SET-2. J Biol Chem. 2008 Nov 21;283(47):32334-43. DM95Y82 RU https://pubmed.ncbi.nlm.nih.gov/18775810 DMOSI4U DI DMOSI4U DMOSI4U DN Aza-C-nucleosides DMOSI4U MI TTMCF1Y DMOSI4U MN Purine nucleoside phosphorylase (PNP) DMOSI4U MT DTT DMOSI4U MA Inhibitor DMOSI4U RN Exploring structure-activity relationships of transition state analogues of human purine nucleoside phosphorylase. J Med Chem. 2003 Jul 17;46(15):3412-23. DMOSI4U RU https://pubmed.ncbi.nlm.nih.gov/12852771 DM61H07 DI DM61H07 DM61H07 DN AZAKENPAULLONE DM61H07 MI TTH6V3D DM61H07 MN Cyclin-dependent kinase 1 (CDK1) DM61H07 MT DTT DM61H07 MA Inhibitor DM61H07 RN 1-Azakenpaullone is a selective inhibitor of glycogen synthase kinase-3 beta. Bioorg Med Chem Lett. 2004 Jan 19;14(2):413-6. DM61H07 RU https://pubmed.ncbi.nlm.nih.gov/14698171 DM61H07 DI DM61H07 DM61H07 DN AZAKENPAULLONE DM61H07 MI TTL4Q97 DM61H07 MN Cyclin-dependent kinase 5 (CDK5) DM61H07 MT DTT DM61H07 MA Inhibitor DM61H07 RN 1-Azakenpaullone is a selective inhibitor of glycogen synthase kinase-3 beta. Bioorg Med Chem Lett. 2004 Jan 19;14(2):413-6. DM61H07 RU https://pubmed.ncbi.nlm.nih.gov/14698171 DM61H07 DI DM61H07 DM61H07 DN AZAKENPAULLONE DM61H07 MI TT9P6OW DM61H07 MN G2/mitotic-specific cyclin B1 (CCNB1) DM61H07 MT DTT DM61H07 MA Inhibitor DM61H07 RN 1-Azakenpaullone is a selective inhibitor of glycogen synthase kinase-3 beta. Bioorg Med Chem Lett. 2004 Jan 19;14(2):413-6. DM61H07 RU https://pubmed.ncbi.nlm.nih.gov/14698171 DM61H07 DI DM61H07 DM61H07 DN AZAKENPAULLONE DM61H07 MI TTRSMW9 DM61H07 MN Glycogen synthase kinase-3 beta (GSK-3B) DM61H07 MT DTT DM61H07 MA Inhibitor DM61H07 RN 1-Azakenpaullone is a selective inhibitor of glycogen synthase kinase-3 beta. Bioorg Med Chem Lett. 2004 Jan 19;14(2):413-6. DM61H07 RU https://pubmed.ncbi.nlm.nih.gov/14698171 DMN861Q DI DMN861Q DMN861Q DN AZALINE B DMN861Q MI TT8R70G DMN861Q MN Gonadotropin-releasing hormone receptor (GNRHR) DMN861Q MT DTT DMN861Q MA Inhibitor DMN861Q RN Structure-activity relationship studies of gonadotropin-releasing hormone antagonists containing S-aryl/alkyl norcysteines and their oxidized deriv... J Med Chem. 2007 May 3;50(9):2067-77. DMN861Q RU https://pubmed.ncbi.nlm.nih.gov/17402723 DM3BXUJ DI DM3BXUJ DM3BXUJ DN Azapeptide DM3BXUJ MI TTWXB3E DM3BXUJ MN Hepatitis C virus NS3 helicase (HCV NS3) DM3BXUJ MT DTT DM3BXUJ MA Inhibitor DM3BXUJ RN Azapeptides as inhibitors of the hepatitis C virus NS3 serine protease. Bioorg Med Chem Lett. 2002 Apr 8;12(7):1005-8. DM3BXUJ RU https://pubmed.ncbi.nlm.nih.gov/11909704 DMKI2GJ DI DMKI2GJ DMKI2GJ DN Azaperone DMKI2GJ MI TTEX248 DMKI2GJ MN Dopamine D2 receptor (D2R) DMKI2GJ MT DTT DMKI2GJ MA Inhibitor DMKI2GJ RN Evaluation of the effects of the enantiomers of reduced haloperidol, azaperol, and related 4-amino-1-arylbutanols on dopamine and sigma receptors. J Med Chem. 1993 Nov 26;36(24):3929-36. DMKI2GJ RU https://pubmed.ncbi.nlm.nih.gov/7902870 DMKI2GJ DI DMKI2GJ DMKI2GJ DN Azaperone DMKI2GJ MI TT4C8EA DMKI2GJ MN Dopamine D3 receptor (D3R) DMKI2GJ MT DTT DMKI2GJ MA Inhibitor DMKI2GJ RN Evaluation of the effects of the enantiomers of reduced haloperidol, azaperol, and related 4-amino-1-arylbutanols on dopamine and sigma receptors. J Med Chem. 1993 Nov 26;36(24):3929-36. DMKI2GJ RU https://pubmed.ncbi.nlm.nih.gov/7902870 DML70NC DI DML70NC DML70NC DN aza-THIP DML70NC MI TT6XFEU DML70NC MN GABA(A) receptor rho1 (GABRR1) DML70NC MT DTT DML70NC MA Antagonist DML70NC RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 420). DML70NC RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=420 DML70NC DI DML70NC DML70NC DN aza-THIP DML70NC MI TTQMXLS DML70NC MN GABA(A) receptor rho2 (GABRR2) DML70NC MT DTT DML70NC MA Antagonist DML70NC RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 421). DML70NC RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=421 DML70NC DI DML70NC DML70NC DN aza-THIP DML70NC MI TT4N6D8 DML70NC MN GABA(A) receptor rho3 (GABRR3) DML70NC MT DTT DML70NC MA Antagonist DML70NC RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 422). DML70NC RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=422 DM0PVD9 DI DM0PVD9 DM0PVD9 DN AZD1332 DM0PVD9 MI TTKN7QR DM0PVD9 MN BDNF/NT-3 growth factors receptor (TrkB) DM0PVD9 MT DTT DM0PVD9 MA Inhibitor DM0PVD9 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1818). DM0PVD9 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1818 DM0PVD9 DI DM0PVD9 DM0PVD9 DN AZD1332 DM0PVD9 MI TTXABCW DM0PVD9 MN NT-3 growth factor receptor (TrkC) DM0PVD9 MT DTT DM0PVD9 MA Inhibitor DM0PVD9 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1817). DM0PVD9 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1817 DMAX9C3 DI DMAX9C3 DMAX9C3 DN AZD3463 DMAX9C3 MI TTPMQSO DMAX9C3 MN ALK tyrosine kinase receptor (ALK) DMAX9C3 MT DTT DMAX9C3 MA Inhibitor DMAX9C3 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1839). DMAX9C3 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1839 DMAX9C3 DI DMAX9C3 DMAX9C3 DN AZD3463 DMAX9C3 MI TTQFBMY DMAX9C3 MN IGF1R messenger RNA (IGF1R mRNA) DMAX9C3 MT DTT DMAX9C3 MA Inhibitor DMAX9C3 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1801). DMAX9C3 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1801 DMPIHN6 DI DMPIHN6 DMPIHN6 DN AZD5582 DMPIHN6 MI TTQ5LRD DMPIHN6 MN Cellular inhibitor of apoptosis 1 (BIRC2) DMPIHN6 MT DTT DMPIHN6 MA Antagonist DMPIHN6 RN Discovery of a novel class of dimeric Smac mimetics as potent IAP antagonists resulting in a clinical candidate for the treatment of cancer (AZD5582). J Med Chem. 2013 Dec 27;56(24):9897-919. DMPIHN6 RU https://pubmed.ncbi.nlm.nih.gov/24320998 DMPIHN6 DI DMPIHN6 DMPIHN6 DN AZD5582 DMPIHN6 MI TTIRY6K DMPIHN6 MN Cellular inhibitor of apoptosis 2 (BIRC3) DMPIHN6 MT DTT DMPIHN6 MA Antagonist DMPIHN6 RN Discovery of a novel class of dimeric Smac mimetics as potent IAP antagonists resulting in a clinical candidate for the treatment of cancer (AZD5582). J Med Chem. 2013 Dec 27;56(24):9897-919. DMPIHN6 RU https://pubmed.ncbi.nlm.nih.gov/24320998 DMPIHN6 DI DMPIHN6 DMPIHN6 DN AZD5582 DMPIHN6 MI TTK3WBU DMPIHN6 MN XIAP messenger RNA (XIAP mRNA) DMPIHN6 MT DTT DMPIHN6 MA Antagonist DMPIHN6 RN Discovery of a novel class of dimeric Smac mimetics as potent IAP antagonists resulting in a clinical candidate for the treatment of cancer (AZD5582). J Med Chem. 2013 Dec 27;56(24):9897-919. DMPIHN6 RU https://pubmed.ncbi.nlm.nih.gov/24320998 DMD4YO9 DI DMD4YO9 DMD4YO9 DN AZD-6319 DMD4YO9 MI TTLA931 DMD4YO9 MN Neuronal acetylcholine receptor alpha-7 (CHRNA7) DMD4YO9 MT DTT DMD4YO9 MA Agonist DMD4YO9 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 468). DMD4YO9 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=468 DMLJPDW DI DMLJPDW DMLJPDW DN AZD-7507 DMLJPDW MI TTC70AJ DMLJPDW MN Granulocyte colony-stimulating factor receptor (G-CSF-R) DMLJPDW MT DTT DMLJPDW MA Inhibitor DMLJPDW RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1719). DMLJPDW RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1719 DM34W56 DI DM34W56 DM34W56 DN AZD-7806 DM34W56 MI TTPI1M5 DM34W56 MN Ileal sodium/bile acid cotransporter (SLC10A2) DM34W56 MT DTT DM34W56 MA Modulator DM34W56 RN Elobixibat for the treatment of constipation. Expert Opin Investig Drugs. 2013 Feb;22(2):277-84. DM34W56 RU https://pubmed.ncbi.nlm.nih.gov/23215781 DM0HTXO DI DM0HTXO DM0HTXO DN AZD8542 DM0HTXO MI TT8J1S3 DM0HTXO MN Smoothened homolog (SMO) DM0HTXO MT DTT DM0HTXO MA Antagonist DM0HTXO RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 239). DM0HTXO RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=239 DMKSQY1 DI DMKSQY1 DMKSQY1 DN Azelaic bishydroxamic acid DMKSQY1 MI TTBH0VX DMKSQY1 MN Histone deacetylase (HDAC) DMKSQY1 MT DTT DMKSQY1 MA Inhibitor DMKSQY1 RN Anticancer activities of histone deacetylase inhibitors. Nat Rev Drug Discov. 2006 Sep;5(9):769-84. DMKSQY1 RU https://pubmed.ncbi.nlm.nih.gov/16955068 DMZHV39 DI DMZHV39 DMZHV39 DN Azepan-(2Z)-ylideneamine DMZHV39 MI TTZUFI5 DMZHV39 MN Nitric-oxide synthase brain (NOS1) DMZHV39 MT DTT DMZHV39 MA Inhibitor DMZHV39 RN Selective heterocyclic amidine inhibitors of human inducible nitric oxide synthase. Bioorg Med Chem Lett. 2001 Oct 8;11(19):2651-3. DMZHV39 RU https://pubmed.ncbi.nlm.nih.gov/11551770 DMZHV39 DI DMZHV39 DMZHV39 DN Azepan-(2Z)-ylideneamine DMZHV39 MI TTCM4B3 DMZHV39 MN Nitric-oxide synthase endothelial (NOS3) DMZHV39 MT DTT DMZHV39 MA Inhibitor DMZHV39 RN Selective heterocyclic amidine inhibitors of human inducible nitric oxide synthase. Bioorg Med Chem Lett. 2001 Oct 8;11(19):2651-3. DMZHV39 RU https://pubmed.ncbi.nlm.nih.gov/11551770 DMZHV39 DI DMZHV39 DMZHV39 DN Azepan-(2Z)-ylideneamine DMZHV39 MI TTF10I9 DMZHV39 MN Nitric-oxide synthase inducible (NOS2) DMZHV39 MT DTT DMZHV39 MA Inhibitor DMZHV39 RN Selective heterocyclic amidine inhibitors of human inducible nitric oxide synthase. Bioorg Med Chem Lett. 2001 Oct 8;11(19):2651-3. DMZHV39 RU https://pubmed.ncbi.nlm.nih.gov/11551770 DM5XZYB DI DM5XZYB DM5XZYB DN Azide DM5XZYB MI TTHQPL7 DM5XZYB MN Carbonic anhydrase I (CA-I) DM5XZYB MT DTT DM5XZYB MA Inhibitor DM5XZYB RN Carbonic anhydrase inhibitors: inhibition of the membrane-bound human isozyme IV with anions. Bioorg Med Chem Lett. 2004 Dec 6;14(23):5769-73. DM5XZYB RU https://pubmed.ncbi.nlm.nih.gov/15501038 DM5XZYB DI DM5XZYB DM5XZYB DN Azide DM5XZYB MI TTANPDJ DM5XZYB MN Carbonic anhydrase II (CA-II) DM5XZYB MT DTT DM5XZYB MA Inhibitor DM5XZYB RN Carbonic anhydrase inhibitors. Inhibition of the newly isolated murine isozyme XIII with anions. Bioorg Med Chem Lett. 2004 Nov 1;14(21):5435-9. DM5XZYB RU https://pubmed.ncbi.nlm.nih.gov/15454240 DM5XZYB DI DM5XZYB DM5XZYB DN Azide DM5XZYB MI TT2LVK8 DM5XZYB MN Carbonic anhydrase IX (CA-IX) DM5XZYB MT DTT DM5XZYB MA Inhibitor DM5XZYB RN Carbonic anhydrase inhibitors: inhibition of the membrane-bound human isozyme IV with anions. Bioorg Med Chem Lett. 2004 Dec 6;14(23):5769-73. DM5XZYB RU https://pubmed.ncbi.nlm.nih.gov/15501038 DMD0LCA DI DMD0LCA DMD0LCA DN Azidopine DMD0LCA MI DTUGYRD DMD0LCA MN P-glycoprotein 1 (ABCB1) DMD0LCA MT DTP DMD0LCA MA Substrate DMD0LCA RN Mammalian drug efflux transporters of the ATP binding cassette (ABC) family in multidrug resistance: A review of the past decade. Cancer Lett. 2016 Jan 1;370(1):153-64. DMD0LCA RU http://www.ncbi.nlm.nih.gov/pubmed/26499806 DMD0LCA DI DMD0LCA DMD0LCA DN Azidopine DMD0LCA MI TT7RGTM DMD0LCA MN Voltage-gated calcium channel alpha Cav1.3 (CACNA1D) DMD0LCA MT DTT DMD0LCA MA Inhibitor (gating inhibitor) DMD0LCA RN Expression and 1,4-dihydropyridine-binding properties of brain L-type calcium channel isoforms. Mol Pharmacol. 2009 Feb;75(2):407-14. DMD0LCA RU https://pubmed.ncbi.nlm.nih.gov/19029287 DM8ZQG3 DI DM8ZQG3 DM8ZQG3 DN Azithromycinarylalkylhydroxamic Acid DM8ZQG3 MI TT6R7JZ DM8ZQG3 MN Histone deacetylase 1 (HDAC1) DM8ZQG3 MT DTT DM8ZQG3 MA Inhibitor DM8ZQG3 RN Non-peptide macrocyclic histone deacetylase inhibitors. J Med Chem. 2009 Jan 22;52(2):456-68. DM8ZQG3 RU https://pubmed.ncbi.nlm.nih.gov/19093884 DM8ZQG3 DI DM8ZQG3 DM8ZQG3 DN Azithromycinarylalkylhydroxamic Acid DM8ZQG3 MI TTT6LFV DM8ZQG3 MN Histone deacetylase 8 (HDAC8) DM8ZQG3 MT DTT DM8ZQG3 MA Inhibitor DM8ZQG3 RN Non-peptide macrocyclic histone deacetylase inhibitors. J Med Chem. 2009 Jan 22;52(2):456-68. DM8ZQG3 RU https://pubmed.ncbi.nlm.nih.gov/19093884 DMDQ2VN DI DMDQ2VN DMDQ2VN DN Azithromycin-N-benzyltriazolyldecahydroxamic Acid DMDQ2VN MI TT6R7JZ DMDQ2VN MN Histone deacetylase 1 (HDAC1) DMDQ2VN MT DTT DMDQ2VN MA Inhibitor DMDQ2VN RN Non-peptide macrocyclic histone deacetylase inhibitors. J Med Chem. 2009 Jan 22;52(2):456-68. DMDQ2VN RU https://pubmed.ncbi.nlm.nih.gov/19093884 DM7KD5Y DI DM7KD5Y DM7KD5Y DN Azithromycin-N-benzyltriazolylhexahydroxamic Acid DM7KD5Y MI TT6R7JZ DM7KD5Y MN Histone deacetylase 1 (HDAC1) DM7KD5Y MT DTT DM7KD5Y MA Inhibitor DM7KD5Y RN Non-peptide macrocyclic histone deacetylase inhibitors. J Med Chem. 2009 Jan 22;52(2):456-68. DM7KD5Y RU https://pubmed.ncbi.nlm.nih.gov/19093884 DM7KD5Y DI DM7KD5Y DM7KD5Y DN Azithromycin-N-benzyltriazolylhexahydroxamic Acid DM7KD5Y MI TTT6LFV DM7KD5Y MN Histone deacetylase 8 (HDAC8) DM7KD5Y MT DTT DM7KD5Y MA Inhibitor DM7KD5Y RN Non-peptide macrocyclic histone deacetylase inhibitors. J Med Chem. 2009 Jan 22;52(2):456-68. DM7KD5Y RU https://pubmed.ncbi.nlm.nih.gov/19093884 DMW0HXO DI DMW0HXO DMW0HXO DN Azithromycin-N-benzyltriazolylnonahydroxamic Acid DMW0HXO MI TT6R7JZ DMW0HXO MN Histone deacetylase 1 (HDAC1) DMW0HXO MT DTT DMW0HXO MA Inhibitor DMW0HXO RN Non-peptide macrocyclic histone deacetylase inhibitors. J Med Chem. 2009 Jan 22;52(2):456-68. DMW0HXO RU https://pubmed.ncbi.nlm.nih.gov/19093884 DMW0HXO DI DMW0HXO DMW0HXO DN Azithromycin-N-benzyltriazolylnonahydroxamic Acid DMW0HXO MI TTT6LFV DMW0HXO MN Histone deacetylase 8 (HDAC8) DMW0HXO MT DTT DMW0HXO MA Inhibitor DMW0HXO RN Non-peptide macrocyclic histone deacetylase inhibitors. J Med Chem. 2009 Jan 22;52(2):456-68. DMW0HXO RU https://pubmed.ncbi.nlm.nih.gov/19093884 DMAJ4LI DI DMAJ4LI DMAJ4LI DN Azithromycin-N-benzyltriazolyloctahydroxamic Acid DMAJ4LI MI TT6R7JZ DMAJ4LI MN Histone deacetylase 1 (HDAC1) DMAJ4LI MT DTT DMAJ4LI MA Inhibitor DMAJ4LI RN Non-peptide macrocyclic histone deacetylase inhibitors. J Med Chem. 2009 Jan 22;52(2):456-68. DMAJ4LI RU https://pubmed.ncbi.nlm.nih.gov/19093884 DMAJ4LI DI DMAJ4LI DMAJ4LI DN Azithromycin-N-benzyltriazolyloctahydroxamic Acid DMAJ4LI MI TTT6LFV DMAJ4LI MN Histone deacetylase 8 (HDAC8) DMAJ4LI MT DTT DMAJ4LI MA Inhibitor DMAJ4LI RN Non-peptide macrocyclic histone deacetylase inhibitors. J Med Chem. 2009 Jan 22;52(2):456-68. DMAJ4LI RU https://pubmed.ncbi.nlm.nih.gov/19093884 DMQ13PZ DI DMQ13PZ DMQ13PZ DN Azocan-(2Z)-ylideneamine DMQ13PZ MI TTZUFI5 DMQ13PZ MN Nitric-oxide synthase brain (NOS1) DMQ13PZ MT DTT DMQ13PZ MA Inhibitor DMQ13PZ RN Selective heterocyclic amidine inhibitors of human inducible nitric oxide synthase. Bioorg Med Chem Lett. 2001 Oct 8;11(19):2651-3. DMQ13PZ RU https://pubmed.ncbi.nlm.nih.gov/11551770 DMQ13PZ DI DMQ13PZ DMQ13PZ DN Azocan-(2Z)-ylideneamine DMQ13PZ MI TTF10I9 DMQ13PZ MN Nitric-oxide synthase inducible (NOS2) DMQ13PZ MT DTT DMQ13PZ MA Inhibitor DMQ13PZ RN Selective heterocyclic amidine inhibitors of human inducible nitric oxide synthase. Bioorg Med Chem Lett. 2001 Oct 8;11(19):2651-3. DMQ13PZ RU https://pubmed.ncbi.nlm.nih.gov/11551770 DMTQSNK DI DMTQSNK DMTQSNK DN Azonan-(2Z)-ylideneamine DMTQSNK MI TTZUFI5 DMTQSNK MN Nitric-oxide synthase brain (NOS1) DMTQSNK MT DTT DMTQSNK MA Inhibitor DMTQSNK RN 2-Iminopiperidine and other 2-iminoazaheterocycles as potent inhibitors of human nitric oxide synthase isoforms. J Med Chem. 1996 Feb 2;39(3):669-72. DMTQSNK RU https://pubmed.ncbi.nlm.nih.gov/8576908 DMTQSNK DI DMTQSNK DMTQSNK DN Azonan-(2Z)-ylideneamine DMTQSNK MI TTF10I9 DMTQSNK MN Nitric-oxide synthase inducible (NOS2) DMTQSNK MT DTT DMTQSNK MA Inhibitor DMTQSNK RN 2-Iminopiperidine and other 2-iminoazaheterocycles as potent inhibitors of human nitric oxide synthase isoforms. J Med Chem. 1996 Feb 2;39(3):669-72. DMTQSNK RU https://pubmed.ncbi.nlm.nih.gov/8576908 DMD4LGN DI DMD4LGN DMD4LGN DN AZ-TAK1 DMD4LGN MI TTJQT60 DMD4LGN MN TGF-beta-activated kinase 1 (MAP3K7) DMD4LGN MT DTT DMD4LGN MA Inhibitor DMD4LGN RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2082). DMD4LGN RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2082 DMXOGE8 DI DMXOGE8 DMXOGE8 DN AZUMAMIDE B DMXOGE8 MI TT6R7JZ DMXOGE8 MN Histone deacetylase 1 (HDAC1) DMXOGE8 MT DTT DMXOGE8 MA Inhibitor DMXOGE8 RN Evaluation of antiangiogenic activity of azumamides by the in vitro vascular organization model using mouse induced pluripotent stem (iPS) cells. Bioorg Med Chem Lett. 2008 May 1;18(9):2982-4. DMXOGE8 RU https://pubmed.ncbi.nlm.nih.gov/18397826 DMXOGE8 DI DMXOGE8 DMXOGE8 DN AZUMAMIDE B DMXOGE8 MI TTTQGH8 DMXOGE8 MN Histone deacetylase 4 (HDAC4) DMXOGE8 MT DTT DMXOGE8 MA Inhibitor DMXOGE8 RN Evaluation of antiangiogenic activity of azumamides by the in vitro vascular organization model using mouse induced pluripotent stem (iPS) cells. Bioorg Med Chem Lett. 2008 May 1;18(9):2982-4. DMXOGE8 RU https://pubmed.ncbi.nlm.nih.gov/18397826 DMEBA61 DI DMEBA61 DMEBA61 DN AZUMAMIDE C DMEBA61 MI TT6R7JZ DMEBA61 MN Histone deacetylase 1 (HDAC1) DMEBA61 MT DTT DMEBA61 MA Inhibitor DMEBA61 RN Evaluation of antiangiogenic activity of azumamides by the in vitro vascular organization model using mouse induced pluripotent stem (iPS) cells. Bioorg Med Chem Lett. 2008 May 1;18(9):2982-4. DMEBA61 RU https://pubmed.ncbi.nlm.nih.gov/18397826 DMEBA61 DI DMEBA61 DMEBA61 DN AZUMAMIDE C DMEBA61 MI TTTQGH8 DMEBA61 MN Histone deacetylase 4 (HDAC4) DMEBA61 MT DTT DMEBA61 MA Inhibitor DMEBA61 RN Evaluation of antiangiogenic activity of azumamides by the in vitro vascular organization model using mouse induced pluripotent stem (iPS) cells. Bioorg Med Chem Lett. 2008 May 1;18(9):2982-4. DMEBA61 RU https://pubmed.ncbi.nlm.nih.gov/18397826 DMAX06G DI DMAX06G DMAX06G DN AZUMAMIDE E DMAX06G MI TT6R7JZ DMAX06G MN Histone deacetylase 1 (HDAC1) DMAX06G MT DTT DMAX06G MA Inhibitor DMAX06G RN Evaluation of antiangiogenic activity of azumamides by the in vitro vascular organization model using mouse induced pluripotent stem (iPS) cells. Bioorg Med Chem Lett. 2008 May 1;18(9):2982-4. DMAX06G RU https://pubmed.ncbi.nlm.nih.gov/18397826 DMAX06G DI DMAX06G DMAX06G DN AZUMAMIDE E DMAX06G MI TTTQGH8 DMAX06G MN Histone deacetylase 4 (HDAC4) DMAX06G MT DTT DMAX06G MA Inhibitor DMAX06G RN Evaluation of antiangiogenic activity of azumamides by the in vitro vascular organization model using mouse induced pluripotent stem (iPS) cells. Bioorg Med Chem Lett. 2008 May 1;18(9):2982-4. DMAX06G RU https://pubmed.ncbi.nlm.nih.gov/18397826 DMN2XTQ DI DMN2XTQ DMN2XTQ DN B173 DMN2XTQ MI TTCPG9S DMN2XTQ MN 5-HT 1E receptor (HTR1E) DMN2XTQ MT DTT DMN2XTQ MA Agonist DMN2XTQ RN The gamma-aminobutyric acid-B receptor agonist baclofen attenuates responding for ethanol in ethanol-dependent rats. Alcohol Clin Exp Res. 2007 Jan;31(1):11-8. DMN2XTQ RU https://pubmed.ncbi.nlm.nih.gov/17207096 DMEGX8H DI DMEGX8H DMEGX8H DN B-2-Octylglucoside DMEGX8H MI TTRAMF0 DMEGX8H MN Plasmodium Cytochrome B (Malaria MT-CYB) DMEGX8H MT DTT DMEGX8H MA Inhibitor DMEGX8H RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMEGX8H RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMEGX8H DI DMEGX8H DMEGX8H DN B-2-Octylglucoside DMEGX8H MI TTH0KSX DMEGX8H MN Rhodopsin (RHO) DMEGX8H MT DTT DMEGX8H MA Inhibitor DMEGX8H RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMEGX8H RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMV3H0C DI DMV3H0C DMV3H0C DN B3C DMV3H0C MI TTT4N0Q DMV3H0C MN Channel-activating protease 1 (CAP1) DMV3H0C MT DTT DMV3H0C MA Inhibitor DMV3H0C RN Discovery of inhibitors of the channel-activating protease prostasin (CAP1/PRSS8) utilizing structure-based design. Bioorg Med Chem Lett. 2008 Nov 15;18(22):5895-9. DMV3H0C RU https://pubmed.ncbi.nlm.nih.gov/18752942 DMIUD0L DI DMIUD0L DMIUD0L DN B-623 DMIUD0L MI TTGY7WI DMIUD0L MN Urokinase-type plasminogen activator (PLAU) DMIUD0L MT DTT DMIUD0L MA Modulator DMIUD0L RN Angiostatic activity of synthetic inhibitors of urokinase type plasminogen activator. Oncol Rep. 1999 May-Jun;6(3):523-6. DMIUD0L RU https://www.ncbi.nlm.nih.gov/pubmed/10203585 DMCK5DG DI DMCK5DG DMCK5DG DN BADGE DMCK5DG MI TTT2SVW DMCK5DG MN PPAR-gamma messenger RNA (PPARG mRNA) DMCK5DG MT DTT DMCK5DG MA Agonist DMCK5DG RN A synthetic antagonist for the peroxisome proliferator-activated receptor gamma inhibits adipocyte differentiation. J Biol Chem. 2000 Jan 21;275(3):1873-7. DMCK5DG RU https://pubmed.ncbi.nlm.nih.gov/10636887 DMUNK59 DI DMUNK59 DMUNK59 DN Bafilomycin A1 DMUNK59 MI TTTK3BH DMUNK59 MN Vacuolar-type proton ATPase (v-ATPase) DMUNK59 MT DTT DMUNK59 MA Inhibitor DMUNK59 RN Molecular basis of V-ATPase inhibition by bafilomycin A1. Nat Commun. 2021 Mar 19;12(1):1782. DMUNK59 RU https://pubmed.ncbi.nlm.nih.gov/33741963 DMSWQED DI DMSWQED DMSWQED DN bag-1 DMSWQED MI TTHYDUM DMSWQED MN Bombesin receptor (BS) DMSWQED MT DTT DMSWQED MA Agonist DMSWQED RN Regulation of energy homeostasis by bombesin receptor subtype-3: selective receptor agonists for the treatment of obesity. Cell Metab. 2010 Feb 3;11(2):101-12. DMSWQED RU https://pubmed.ncbi.nlm.nih.gov/20096642 DMWC34B DI DMWC34B DMWC34B DN BAG956 DMWC34B MI TTHBTOP DMWC34B MN PI3-kinase gamma (PIK3CG) DMWC34B MT DTT DMWC34B MA Inhibitor DMWC34B RN The PI3K/Akt pathway as a target in the treatment of hematologic malignancies. Anticancer Agents Med Chem. 2009 Jun;9(5):550-9. DMWC34B RU https://pubmed.ncbi.nlm.nih.gov/19519296 DMX6KTO DI DMX6KTO DMX6KTO DN BAN-2203 DMX6KTO MI TTE4KHA DMX6KTO MN Amyloid beta A4 protein (APP) DMX6KTO MT DTT DMX6KTO MA Modulator DMX6KTO RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2402). DMX6KTO RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2402 DM4OT8M DI DM4OT8M DM4OT8M DN bantag-1 DM4OT8M MI TTHYDUM DM4OT8M MN Bombesin receptor (BS) DM4OT8M MT DTT DM4OT8M MA Antagonist DM4OT8M RN Comparative pharmacology of bombesin receptor subtype-3, nonpeptide agonist MK-5046, a universal peptide agonist, and peptide antagonist Bantag-1 for human bombesin receptors. J Pharmacol Exp Ther. 2013 Oct;347(1):100-16. DM4OT8M RU https://pubmed.ncbi.nlm.nih.gov/23892571 DM4OT8M DI DM4OT8M DM4OT8M DN bantag-1 DM4OT8M MI TTC1MVT DM4OT8M MN Gastrin-releasing peptide receptor (GRPR) DM4OT8M MT DTT DM4OT8M MA Antagonist DM4OT8M RN Comparative pharmacology of bombesin receptor subtype-3, nonpeptide agonist MK-5046, a universal peptide agonist, and peptide antagonist Bantag-1 for human bombesin receptors. J Pharmacol Exp Ther. 2013 Oct;347(1):100-16. DM4OT8M RU https://pubmed.ncbi.nlm.nih.gov/23892571 DM9JXIZ DI DM9JXIZ DM9JXIZ DN banyu (I) DM9JXIZ MI TTU3Y87 DM9JXIZ MN CCR3 messenger RNA (CCR3 mRNA) DM9JXIZ MT DTT DM9JXIZ MA Antagonist DM9JXIZ RN Identification of full, partial and inverse CC chemokine receptor 3 agonists using [35S]GTPgammaS binding. Eur J Pharmacol. 2002 Dec 5;456(1-3):1-10. DM9JXIZ RU https://pubmed.ncbi.nlm.nih.gov/12450563 DMD26XN DI DMD26XN DMD26XN DN Banyu Compound-24 DMD26XN MI TTNT7K8 DMD26XN MN Nociceptin receptor (OPRL1) DMD26XN MT DTT DMD26XN MA Antagonist DMD26XN RN Pharmacological characterization of the nociceptin/orphanin FQ receptor non peptide antagonist Compound 24. Eur J Pharmacol. 2009 Jul 1;614(1-3):50-7. DMD26XN RU https://pubmed.ncbi.nlm.nih.gov/19445927 DM2I19P DI DM2I19P DM2I19P DN Barbituric acid derivative DM2I19P MI TT1MPAY DM2I19P MN GABA(A) receptor alpha-1 (GABRA1) DM2I19P MT DTT DM2I19P MA Inhibitor DM2I19P RN Whiting PJ: The GABAA receptor gene family: new opportunities for drug development. Curr Opin Drug Discov Devel. 2003 Sep;6(5):648-57. DM2I19P RU https://pubmed.ncbi.nlm.nih.gov/14579514 DM2I19P DI DM2I19P DM2I19P DN Barbituric acid derivative DM2I19P MI TTBMV1G DM2I19P MN GABA(A) receptor alpha-2 (GABRA2) DM2I19P MT DTT DM2I19P MA Inhibitor DM2I19P RN Whiting PJ: The GABAA receptor gene family: new opportunities for drug development. Curr Opin Drug Discov Devel. 2003 Sep;6(5):648-57. DM2I19P RU https://pubmed.ncbi.nlm.nih.gov/14579514 DM2I19P DI DM2I19P DM2I19P DN Barbituric acid derivative DM2I19P MI TT37EDJ DM2I19P MN GABA(A) receptor alpha-3 (GABRA3) DM2I19P MT DTT DM2I19P MA Inhibitor DM2I19P RN Whiting PJ: The GABAA receptor gene family: new opportunities for drug development. Curr Opin Drug Discov Devel. 2003 Sep;6(5):648-57. DM2I19P RU https://pubmed.ncbi.nlm.nih.gov/14579514 DM2I19P DI DM2I19P DM2I19P DN Barbituric acid derivative DM2I19P MI TTNZPQ1 DM2I19P MN GABA(A) receptor alpha-5 (GABRA5) DM2I19P MT DTT DM2I19P MA Inhibitor DM2I19P RN Whiting PJ: The GABAA receptor gene family: new opportunities for drug development. Curr Opin Drug Discov Devel. 2003 Sep;6(5):648-57. DM2I19P RU https://pubmed.ncbi.nlm.nih.gov/14579514 DM2I19P DI DM2I19P DM2I19P DN Barbituric acid derivative DM2I19P MI TT4H1MQ DM2I19P MN Neuronal acetylcholine receptor alpha-4 (CHRNA4) DM2I19P MT DTT DM2I19P MA Antagonist DM2I19P RN Whiting PJ: The GABAA receptor gene family: new opportunities for drug development. Curr Opin Drug Discov Devel. 2003 Sep;6(5):648-57. DM2I19P RU https://pubmed.ncbi.nlm.nih.gov/14579514 DM2I19P DI DM2I19P DM2I19P DN Barbituric acid derivative DM2I19P MI TTLA931 DM2I19P MN Neuronal acetylcholine receptor alpha-7 (CHRNA7) DM2I19P MT DTT DM2I19P MA Antagonist DM2I19P RN Whiting PJ: The GABAA receptor gene family: new opportunities for drug development. Curr Opin Drug Discov Devel. 2003 Sep;6(5):648-57. DM2I19P RU https://pubmed.ncbi.nlm.nih.gov/14579514 DMU3D2O DI DMU3D2O DMU3D2O DN BARETTIN DMU3D2O MI TTJQOD7 DMU3D2O MN 5-HT 2A receptor (HTR2A) DMU3D2O MT DTT DMU3D2O MA Inhibitor DMU3D2O RN Brominated cyclodipeptides from the marine sponge Geodia barretti as selective 5-HT ligands. J Nat Prod. 2006 Oct;69(10):1421-4. DMU3D2O RU https://pubmed.ncbi.nlm.nih.gov/17067154 DMU3D2O DI DMU3D2O DMU3D2O DN BARETTIN DMU3D2O MI TTWJBZ5 DMU3D2O MN 5-HT 2C receptor (HTR2C) DMU3D2O MT DTT DMU3D2O MA Inhibitor DMU3D2O RN Brominated cyclodipeptides from the marine sponge Geodia barretti as selective 5-HT ligands. J Nat Prod. 2006 Oct;69(10):1421-4. DMU3D2O RU https://pubmed.ncbi.nlm.nih.gov/17067154 DMU3D2O DI DMU3D2O DMU3D2O DN BARETTIN DMU3D2O MI TT07C3Y DMU3D2O MN 5-HT 4 receptor (HTR4) DMU3D2O MT DTT DMU3D2O MA Inhibitor DMU3D2O RN Brominated cyclodipeptides from the marine sponge Geodia barretti as selective 5-HT ligands. J Nat Prod. 2006 Oct;69(10):1421-4. DMU3D2O RU https://pubmed.ncbi.nlm.nih.gov/17067154 DMZPKGS DI DMZPKGS DMZPKGS DN BAS-00387275 DMZPKGS MI TT6PKBN DMZPKGS MN Proto-oncogene c-Src (SRC) DMZPKGS MT DTT DMZPKGS MA Inhibitor DMZPKGS RN A combination of docking/dynamics simulations and pharmacophoric modeling to discover new dual c-Src/Abl kinase inhibitors. J Med Chem. 2006 Jun 1;49(11):3278-86. DMZPKGS RU https://pubmed.ncbi.nlm.nih.gov/16722646 DMZPKGS DI DMZPKGS DMZPKGS DN BAS-00387275 DMZPKGS MI TT3PJMV DMZPKGS MN Tyrosine-protein kinase ABL1 (ABL) DMZPKGS MT DTT DMZPKGS MA Inhibitor DMZPKGS RN A combination of docking/dynamics simulations and pharmacophoric modeling to discover new dual c-Src/Abl kinase inhibitors. J Med Chem. 2006 Jun 1;49(11):3278-86. DMZPKGS RU https://pubmed.ncbi.nlm.nih.gov/16722646 DM4OSFD DI DM4OSFD DM4OSFD DN BAS-00387328 DM4OSFD MI TT6PKBN DM4OSFD MN Proto-oncogene c-Src (SRC) DM4OSFD MT DTT DM4OSFD MA Inhibitor DM4OSFD RN A combination of docking/dynamics simulations and pharmacophoric modeling to discover new dual c-Src/Abl kinase inhibitors. J Med Chem. 2006 Jun 1;49(11):3278-86. DM4OSFD RU https://pubmed.ncbi.nlm.nih.gov/16722646 DM4OSFD DI DM4OSFD DM4OSFD DN BAS-00387328 DM4OSFD MI TT3PJMV DM4OSFD MN Tyrosine-protein kinase ABL1 (ABL) DM4OSFD MT DTT DM4OSFD MA Inhibitor DM4OSFD RN A combination of docking/dynamics simulations and pharmacophoric modeling to discover new dual c-Src/Abl kinase inhibitors. J Med Chem. 2006 Jun 1;49(11):3278-86. DM4OSFD RU https://pubmed.ncbi.nlm.nih.gov/16722646 DMUF28Q DI DMUF28Q DMUF28Q DN BAS-00387347 DMUF28Q MI TT6PKBN DMUF28Q MN Proto-oncogene c-Src (SRC) DMUF28Q MT DTT DMUF28Q MA Inhibitor DMUF28Q RN A combination of docking/dynamics simulations and pharmacophoric modeling to discover new dual c-Src/Abl kinase inhibitors. J Med Chem. 2006 Jun 1;49(11):3278-86. DMUF28Q RU https://pubmed.ncbi.nlm.nih.gov/16722646 DMUF28Q DI DMUF28Q DMUF28Q DN BAS-00387347 DMUF28Q MI TT3PJMV DMUF28Q MN Tyrosine-protein kinase ABL1 (ABL) DMUF28Q MT DTT DMUF28Q MA Inhibitor DMUF28Q RN A combination of docking/dynamics simulations and pharmacophoric modeling to discover new dual c-Src/Abl kinase inhibitors. J Med Chem. 2006 Jun 1;49(11):3278-86. DMUF28Q RU https://pubmed.ncbi.nlm.nih.gov/16722646 DM6R4X8 DI DM6R4X8 DM6R4X8 DN BAS-00672722 DM6R4X8 MI TT6PKBN DM6R4X8 MN Proto-oncogene c-Src (SRC) DM6R4X8 MT DTT DM6R4X8 MA Inhibitor DM6R4X8 RN A combination of docking/dynamics simulations and pharmacophoric modeling to discover new dual c-Src/Abl kinase inhibitors. J Med Chem. 2006 Jun 1;49(11):3278-86. DM6R4X8 RU https://pubmed.ncbi.nlm.nih.gov/16722646 DM6R4X8 DI DM6R4X8 DM6R4X8 DN BAS-00672722 DM6R4X8 MI TT3PJMV DM6R4X8 MN Tyrosine-protein kinase ABL1 (ABL) DM6R4X8 MT DTT DM6R4X8 MA Inhibitor DM6R4X8 RN A combination of docking/dynamics simulations and pharmacophoric modeling to discover new dual c-Src/Abl kinase inhibitors. J Med Chem. 2006 Jun 1;49(11):3278-86. DM6R4X8 RU https://pubmed.ncbi.nlm.nih.gov/16722646 DMNB7CW DI DMNB7CW DMNB7CW DN BAS-01047341 DMNB7CW MI TT6PKBN DMNB7CW MN Proto-oncogene c-Src (SRC) DMNB7CW MT DTT DMNB7CW MA Inhibitor DMNB7CW RN A combination of docking/dynamics simulations and pharmacophoric modeling to discover new dual c-Src/Abl kinase inhibitors. J Med Chem. 2006 Jun 1;49(11):3278-86. DMNB7CW RU https://pubmed.ncbi.nlm.nih.gov/16722646 DMC0FLB DI DMC0FLB DMC0FLB DN BAS-01047655 DMC0FLB MI TT6PKBN DMC0FLB MN Proto-oncogene c-Src (SRC) DMC0FLB MT DTT DMC0FLB MA Inhibitor DMC0FLB RN A combination of docking/dynamics simulations and pharmacophoric modeling to discover new dual c-Src/Abl kinase inhibitors. J Med Chem. 2006 Jun 1;49(11):3278-86. DMC0FLB RU https://pubmed.ncbi.nlm.nih.gov/16722646 DMZBIC3 DI DMZBIC3 DMZBIC3 DN BAS-01373578 DMZBIC3 MI TT6PKBN DMZBIC3 MN Proto-oncogene c-Src (SRC) DMZBIC3 MT DTT DMZBIC3 MA Inhibitor DMZBIC3 RN A combination of docking/dynamics simulations and pharmacophoric modeling to discover new dual c-Src/Abl kinase inhibitors. J Med Chem. 2006 Jun 1;49(11):3278-86. DMZBIC3 RU https://pubmed.ncbi.nlm.nih.gov/16722646 DMZBIC3 DI DMZBIC3 DMZBIC3 DN BAS-01373578 DMZBIC3 MI TT3PJMV DMZBIC3 MN Tyrosine-protein kinase ABL1 (ABL) DMZBIC3 MT DTT DMZBIC3 MA Inhibitor DMZBIC3 RN A combination of docking/dynamics simulations and pharmacophoric modeling to discover new dual c-Src/Abl kinase inhibitors. J Med Chem. 2006 Jun 1;49(11):3278-86. DMZBIC3 RU https://pubmed.ncbi.nlm.nih.gov/16722646 DMZGLHJ DI DMZGLHJ DMZGLHJ DN BAS-0338868 DMZGLHJ MI TT6PKBN DMZGLHJ MN Proto-oncogene c-Src (SRC) DMZGLHJ MT DTT DMZGLHJ MA Inhibitor DMZGLHJ RN Discovery and SAR of 1,3,4-thiadiazole derivatives as potent Abl tyrosine kinase inhibitors and cytodifferentiating agents. Bioorg Med Chem Lett. 2008 Feb 1;18(3):1207-11. DMZGLHJ RU https://pubmed.ncbi.nlm.nih.gov/18078752 DMZK0SC DI DMZK0SC DMZK0SC DN BAS-0338872 DMZK0SC MI TT6PKBN DMZK0SC MN Proto-oncogene c-Src (SRC) DMZK0SC MT DTT DMZK0SC MA Inhibitor DMZK0SC RN Discovery and SAR of 1,3,4-thiadiazole derivatives as potent Abl tyrosine kinase inhibitors and cytodifferentiating agents. Bioorg Med Chem Lett. 2008 Feb 1;18(3):1207-11. DMZK0SC RU https://pubmed.ncbi.nlm.nih.gov/18078752 DMZK0SC DI DMZK0SC DMZK0SC DN BAS-0338872 DMZK0SC MI TT3PJMV DMZK0SC MN Tyrosine-protein kinase ABL1 (ABL) DMZK0SC MT DTT DMZK0SC MA Inhibitor DMZK0SC RN Discovery and SAR of 1,3,4-thiadiazole derivatives as potent Abl tyrosine kinase inhibitors and cytodifferentiating agents. Bioorg Med Chem Lett. 2008 Feb 1;18(3):1207-11. DMZK0SC RU https://pubmed.ncbi.nlm.nih.gov/18078752 DMBS8N9 DI DMBS8N9 DMBS8N9 DN BAS-0338876 DMBS8N9 MI TT3PJMV DMBS8N9 MN Tyrosine-protein kinase ABL1 (ABL) DMBS8N9 MT DTT DMBS8N9 MA Inhibitor DMBS8N9 RN Discovery and SAR of 1,3,4-thiadiazole derivatives as potent Abl tyrosine kinase inhibitors and cytodifferentiating agents. Bioorg Med Chem Lett. 2008 Feb 1;18(3):1207-11. DMBS8N9 RU https://pubmed.ncbi.nlm.nih.gov/18078752 DMFMBZ9 DI DMFMBZ9 DMFMBZ9 DN BAS-09534324 DMFMBZ9 MI TT6PKBN DMFMBZ9 MN Proto-oncogene c-Src (SRC) DMFMBZ9 MT DTT DMFMBZ9 MA Inhibitor DMFMBZ9 RN A combination of docking/dynamics simulations and pharmacophoric modeling to discover new dual c-Src/Abl kinase inhibitors. J Med Chem. 2006 Jun 1;49(11):3278-86. DMFMBZ9 RU https://pubmed.ncbi.nlm.nih.gov/16722646 DMFMBZ9 DI DMFMBZ9 DMFMBZ9 DN BAS-09534324 DMFMBZ9 MI TT3PJMV DMFMBZ9 MN Tyrosine-protein kinase ABL1 (ABL) DMFMBZ9 MT DTT DMFMBZ9 MA Inhibitor DMFMBZ9 RN A combination of docking/dynamics simulations and pharmacophoric modeling to discover new dual c-Src/Abl kinase inhibitors. J Med Chem. 2006 Jun 1;49(11):3278-86. DMFMBZ9 RU https://pubmed.ncbi.nlm.nih.gov/16722646 DMTH1JQ DI DMTH1JQ DMTH1JQ DN BAS-450225 DMTH1JQ MI TT6PKBN DMTH1JQ MN Proto-oncogene c-Src (SRC) DMTH1JQ MT DTT DMTH1JQ MA Inhibitor DMTH1JQ RN A combination of docking/dynamics simulations and pharmacophoric modeling to discover new dual c-Src/Abl kinase inhibitors. J Med Chem. 2006 Jun 1;49(11):3278-86. DMTH1JQ RU https://pubmed.ncbi.nlm.nih.gov/16722646 DMFNAKU DI DMFNAKU DMFNAKU DN BAS-4844343 DMFNAKU MI TT6PKBN DMFNAKU MN Proto-oncogene c-Src (SRC) DMFNAKU MT DTT DMFNAKU MA Inhibitor DMFNAKU RN A combination of docking/dynamics simulations and pharmacophoric modeling to discover new dual c-Src/Abl kinase inhibitors. J Med Chem. 2006 Jun 1;49(11):3278-86. DMFNAKU RU https://pubmed.ncbi.nlm.nih.gov/16722646 DMTQX1G DI DMTQX1G DMTQX1G DN Batimistat DMTQX1G MI TT6AZXG DMTQX1G MN TNF alpha converting enzyme (ADAM17) DMTQX1G MT DTT DMTQX1G MA Inhibitor DMTQX1G RN The secretases that cleave angiotensin converting enzyme and the amyloid precursor protein are distinct from tumour necrosis factor-alpha convertase. FEBS Lett. 1998 Jul 10;431(1):63-5. DMTQX1G RU https://pubmed.ncbi.nlm.nih.gov/9684866 DMYH9SU DI DMYH9SU DMYH9SU DN Batrachotoxin DMYH9SU MI TTANOZH DMYH9SU MN SCN1A messenger RNA (SCN1A mRNA) DMYH9SU MT DTT DMYH9SU MA Activator DMYH9SU RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 578). DMYH9SU RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=578 DMYH9SU DI DMYH9SU DMYH9SU DN Batrachotoxin DMYH9SU MI TTLJTUF DMYH9SU MN Voltage-gated sodium channel alpha Nav1.2 (SCN2A) DMYH9SU MT DTT DMYH9SU MA Activator DMYH9SU RN Interaction of batrachotoxin with the local anesthetic receptor site in transmembrane segment IVS6 of the voltage-gated sodium channel. Proc Natl Acad Sci U S A. 1998 Nov 10;95(23):13947-52. DMYH9SU RU https://pubmed.ncbi.nlm.nih.gov/9811906 DMYH9SU DI DMYH9SU DMYH9SU DN Batrachotoxin DMYH9SU MI TTAXZ0K DMYH9SU MN Voltage-gated sodium channel alpha Nav1.3 (SCN3A) DMYH9SU MT DTT DMYH9SU MA Activator DMYH9SU RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 580). DMYH9SU RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=580 DMYH9SU DI DMYH9SU DMYH9SU DN Batrachotoxin DMYH9SU MI TT84DRB DMYH9SU MN Voltage-gated sodium channel alpha Nav1.4 (SCN4A) DMYH9SU MT DTT DMYH9SU MA Activator DMYH9SU RN Point mutations in segment I-S6 render voltage-gated Na+ channels resistant to batrachotoxin. Proc Natl Acad Sci U S A. 1998 Mar 3;95(5):2653-8. DMYH9SU RU https://pubmed.ncbi.nlm.nih.gov/9482942 DMYH9SU DI DMYH9SU DMYH9SU DN Batrachotoxin DMYH9SU MI TTZOVE0 DMYH9SU MN Voltage-gated sodium channel alpha Nav1.5 (SCN5A) DMYH9SU MT DTT DMYH9SU MA Activator DMYH9SU RN Binding of [3H]batrachotoxinin A benzoate to specific sites on rat cardiac sodium channels. Mol Pharmacol. 1986 Dec;30(6):617-23. DMYH9SU RU https://pubmed.ncbi.nlm.nih.gov/2431264 DMYH9SU DI DMYH9SU DMYH9SU DN Batrachotoxin DMYH9SU MI TT54ERL DMYH9SU MN Voltage-gated sodium channel alpha Nav1.6 (SCN8A) DMYH9SU MT DTT DMYH9SU MA Activator DMYH9SU RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 583). DMYH9SU RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=583 DMYH9SU DI DMYH9SU DMYH9SU DN Batrachotoxin DMYH9SU MI TT4G2JS DMYH9SU MN Voltage-gated sodium channel alpha Nav1.7 (SCN9A) DMYH9SU MT DTT DMYH9SU MA Activator DMYH9SU RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 584). DMYH9SU RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=584 DMYH9SU DI DMYH9SU DMYH9SU DN Batrachotoxin DMYH9SU MI TT90XZ8 DMYH9SU MN Voltage-gated sodium channel alpha Nav1.8 (SCN10A) DMYH9SU MT DTT DMYH9SU MA Activator DMYH9SU RN The poison Dart frog's batrachotoxin modulates Nav1.8. FEBS Lett. 2004 Nov 5;577(1-2):245-8. DMYH9SU RU https://pubmed.ncbi.nlm.nih.gov/15527793 DMVP74I DI DMVP74I DMVP74I DN BAY 367620 DMVP74I MI TTVBPDM DMVP74I MN Metabotropic glutamate receptor 1 (mGluR1) DMVP74I MT DTT DMVP74I MA Modulator (allosteric modulator) DMVP74I RN BAY36-7620: a potent non-competitive mGlu1 receptor antagonist with inverse agonist activity. Mol Pharmacol. 2001 May;59(5):965-73. DMVP74I RU https://pubmed.ncbi.nlm.nih.gov/11306677 DM743XB DI DM743XB DM743XB DN BAY 50-7952 DM743XB MI TTS7LWX DM743XB MN Bacterial DNA gyrase B (Bact gyrB) DM743XB MT DTT DM743XB MA Inhibitor DM743XB RN seco-Cyclothialidines: new concise synthesis, inhibitory activity toward bacterial and human DNA topoisomerases, and antibacterial properties. J Med Chem. 2001 Feb 15;44(4):619-26. DM743XB RU https://pubmed.ncbi.nlm.nih.gov/11170652 DMRWSGO DI DMRWSGO DMRWSGO DN Bay K 8644 DMRWSGO MI TTXHYV6 DMRWSGO MN Voltage-gated L-type calcium channel (L-CaC) DMRWSGO MT DTT DMRWSGO MA Activator DMRWSGO RN Molecular determinants of drug binding and action on L-type calcium channels. Annu Rev Pharmacol Toxicol. 1997;37:361-96. DMRWSGO RU https://pubmed.ncbi.nlm.nih.gov/9131258 DMQNOFA DI DMQNOFA DMQNOFA DN BAY11-7082 DMQNOFA MI TTSXVID DMQNOFA MN Nuclear factor NF-kappa-B (NFKB) DMQNOFA MT DTT DMQNOFA MA Inhibitor DMQNOFA RN Emerging therapies for multiple myeloma. Expert Opin Emerg Drugs. 2009 Mar;14(1):99-127. DMQNOFA RU https://pubmed.ncbi.nlm.nih.gov/19249983 DM0M59T DI DM0M59T DM0M59T DN BAY412272 DM0M59T MI TTWNFC2 DM0M59T MN Soluble guanylyl cyclase (GUCY2D) DM0M59T MT DTT DM0M59T MA Activator DM0M59T RN NO-independent regulatory site on soluble guanylate cyclase. Nature. 2001 Mar 8;410(6825):212-5. DM0M59T RU https://pubmed.ncbi.nlm.nih.gov/11242081 DMQZ7JD DI DMQZ7JD DMQZ7JD DN BAY-60-7550 DMQZ7JD MI TTJGW1Z DMQZ7JD MN Phosphodiesterase 2A (PDE2A) DMQZ7JD MT DTT DMQZ7JD MA Inhibitor DMQZ7JD RN The next generation of phosphodiesterase inhibitors: structural clues to ligand and substrate selectivity of phosphodiesterases. J Med Chem. 2005 May 19;48(10):3449-62. DMQZ7JD RU https://pubmed.ncbi.nlm.nih.gov/15887951 DM5CPJ2 DI DM5CPJ2 DM5CPJ2 DN BAY-73-1449 DM5CPJ2 MI TTOFYT1 DM5CPJ2 MN Prostacyclin receptor (PTGIR) DM5CPJ2 MT DTT DM5CPJ2 MA Antagonist DM5CPJ2 RN Vascular actions of the prostacyclin receptor antagonist BAY 73-1449 in the portal hypertensive rat. Eur J Pharmacol. 2008 Aug 20;590(1-3):322-6. DM5CPJ2 RU https://pubmed.ncbi.nlm.nih.gov/18603238 DMW625B DI DMW625B DMW625B DN BAY-85-3474 DMW625B MI TTNDSF4 DMW625B MN Proto-oncogene c-Met (MET) DMW625B MT DTT DMW625B MA Inhibitor DMW625B RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1815). DMW625B RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1815 DMKFTZA DI DMKFTZA DMKFTZA DN BayCysLT2 DMKFTZA MI TTGKOY9 DMKFTZA MN Leukotriene CysLT1 receptor (CYSLTR1) DMKFTZA MT DTT DMKFTZA MA Antagonist DMKFTZA RN Synthesis of cysteinyl leukotrienes in human endothelial cells: subcellular localization and autocrine signaling through the CysLT2 receptor. FASEB J. 2011 Oct;25(10):3519-28. DMKFTZA RU https://pubmed.ncbi.nlm.nih.gov/21753081 DMKFTZA DI DMKFTZA DMKFTZA DN BayCysLT2 DMKFTZA MI TT0PZR5 DMKFTZA MN Leukotriene CysLT2 receptor (CYSLTR2) DMKFTZA MT DTT DMKFTZA MA Antagonist DMKFTZA RN Synthesis of cysteinyl leukotrienes in human endothelial cells: subcellular localization and autocrine signaling through the CysLT2 receptor. FASEB J. 2011 Oct;25(10):3519-28. DMKFTZA RU https://pubmed.ncbi.nlm.nih.gov/21753081 DMXQ14V DI DMXQ14V DMXQ14V DN BAYu9773 DMXQ14V MI TTGKOY9 DMXQ14V MN Leukotriene CysLT1 receptor (CYSLTR1) DMXQ14V MT DTT DMXQ14V MA Antagonist DMXQ14V RN Molecular cloning and characterization of a second human cysteinyl leukotriene receptor: discovery of a subtype selective agonist. Mol Pharmacol. 2000 Dec;58(6):1601-8. DMXQ14V RU https://pubmed.ncbi.nlm.nih.gov/11093801 DMXQ14V DI DMXQ14V DMXQ14V DN BAYu9773 DMXQ14V MI TT0PZR5 DMXQ14V MN Leukotriene CysLT2 receptor (CYSLTR2) DMXQ14V MT DTT DMXQ14V MA Antagonist DMXQ14V RN BAY u9773, a novel antagonist of cysteinyl-leukotrienes with activity against two receptor subtypes. Eur J Pharmacol. 1994 Nov 3;264(3):317-23. DMXQ14V RU https://pubmed.ncbi.nlm.nih.gov/7698171 DMKDZLG DI DMKDZLG DMKDZLG DN BAZ2-ICR DMKDZLG MI TT2MV0R DMKDZLG MN Bromodomain adjacent to zinc finger 2A (BAZ2A) DMKDZLG MT DTT DMKDZLG MA Inhibitor DMKDZLG RN Structure enabled design of BAZ2-ICR, a chemical probe targeting the bromodomains of BAZ2A and BAZ2B. J Med Chem. 2015 Mar 12;58(5):2553-9. DMKDZLG RU https://pubmed.ncbi.nlm.nih.gov/25719566 DMKDZLG DI DMKDZLG DMKDZLG DN BAZ2-ICR DMKDZLG MI TT6K8YG DMKDZLG MN Bromodomain adjacent to zinc finger 2B (BAZ2B) DMKDZLG MT DTT DMKDZLG MA Inhibitor DMKDZLG RN Structure enabled design of BAZ2-ICR, a chemical probe targeting the bromodomains of BAZ2A and BAZ2B. J Med Chem. 2015 Mar 12;58(5):2553-9. DMKDZLG RU https://pubmed.ncbi.nlm.nih.gov/25719566 DM5SDV9 DI DM5SDV9 DM5SDV9 DN Bb-3497 DM5SDV9 MI TTICO5G DM5SDV9 MN Staphylococcus Peptide deformylase (Stap-coc def) DM5SDV9 MT DTT DM5SDV9 MA Inhibitor DM5SDV9 RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DM5SDV9 RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMFBN9O DI DMFBN9O DMFBN9O DN BB-78484 DMFBN9O MI TT0OFWN DMFBN9O MN Pseudomonas UDP-3-O-acyl-GlcNAc deacetylase (Pseudo lpxC) DMFBN9O MT DTT DMFBN9O MA Inhibitor DMFBN9O RN Antibacterial activities and characterization of novel inhibitors of LpxC. Antimicrob Agents Chemother. 2002 Jun;46(6):1793-9. DMFBN9O RU https://pubmed.ncbi.nlm.nih.gov/12019092 DMJKA3F DI DMJKA3F DMJKA3F DN BB-78485 DMJKA3F MI TT0OFWN DMJKA3F MN Pseudomonas UDP-3-O-acyl-GlcNAc deacetylase (Pseudo lpxC) DMJKA3F MT DTT DMJKA3F MA Inhibitor DMJKA3F RN Antibacterial activities and characterization of novel inhibitors of LpxC. Antimicrob Agents Chemother. 2002 Jun;46(6):1793-9. DMJKA3F RU https://pubmed.ncbi.nlm.nih.gov/12019092 DMZPL63 DI DMZPL63 DMZPL63 DN BB-823 DMZPL63 MI TTQL5VC DMZPL63 MN Platelet-activating factor receptor (PTAFR) DMZPL63 MT DTT DMZPL63 MA Modulator DMZPL63 RN Platelet-activating factor: the effector of protein-rich plasma extravasation and nitric oxide synthase induction in rat immune complex peritonitis. Br J Pharmacol. 1995 Feb;114(4):895-901. DMZPL63 RU https://pubmed.ncbi.nlm.nih.gov/7539698 DMMUIQ6 DI DMMUIQ6 DMMUIQ6 DN BBI-11008 DMMUIQ6 MI TT27RFC DMMUIQ6 MN Opioid receptor delta (OPRD1) DMMUIQ6 MT DTT DMMUIQ6 MA Agonist DMMUIQ6 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 317). DMMUIQ6 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=317 DM85AJ4 DI DM85AJ4 DM85AJ4 DN BB-PTH 1-84 DM85AJ4 MI TTEPJL5 DM85AJ4 MN Parathyroid hormone receptor (PTH2R) DM85AJ4 MT DTT DM85AJ4 MA Modulator DM85AJ4 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 332). DM85AJ4 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=332 DMMJ4I5 DI DMMJ4I5 DMMJ4I5 DN Bbs-Arg-(D-Pip)-Gly-(EQKLISEEDL)-Gly-Hir DMMJ4I5 MI TT6L509 DMMJ4I5 MN Coagulation factor IIa (F2) DMMJ4I5 MT DTT DMMJ4I5 MA Inhibitor DMMJ4I5 RN Transforming bivalent ligands into retractable enzyme inhibitors through polypeptide-protein interactions. Bioorg Med Chem Lett. 2005 Dec 1;15(23):5120-3. DMMJ4I5 RU https://pubmed.ncbi.nlm.nih.gov/16202582 DM8TH4B DI DM8TH4B DM8TH4B DN Bbs-Arg-(D-Pip)-Gly-(SPH(pY)EKVS)-Gly-Hir DM8TH4B MI TT6L509 DM8TH4B MN Coagulation factor IIa (F2) DM8TH4B MT DTT DM8TH4B MA Inhibitor DM8TH4B RN Transforming bivalent ligands into retractable enzyme inhibitors through polypeptide-protein interactions. Bioorg Med Chem Lett. 2005 Dec 1;15(23):5120-3. DM8TH4B RU https://pubmed.ncbi.nlm.nih.gov/16202582 DMQVRHG DI DMQVRHG DMQVRHG DN Bbs-Arg-(D-Pip)-Gly-(SPHYEKVS)-Gly-Hir DMQVRHG MI TT6L509 DMQVRHG MN Coagulation factor IIa (F2) DMQVRHG MT DTT DMQVRHG MA Inhibitor DMQVRHG RN Transforming bivalent ligands into retractable enzyme inhibitors through polypeptide-protein interactions. Bioorg Med Chem Lett. 2005 Dec 1;15(23):5120-3. DMQVRHG RU https://pubmed.ncbi.nlm.nih.gov/16202582 DMXECFJ DI DMXECFJ DMXECFJ DN Bbs-Arg-(D-Pip)-Gly-S-(GS)11-Gly-Hir DMXECFJ MI TT6L509 DMXECFJ MN Coagulation factor IIa (F2) DMXECFJ MT DTT DMXECFJ MA Inhibitor DMXECFJ RN Transforming bivalent ligands into retractable enzyme inhibitors through polypeptide-protein interactions. Bioorg Med Chem Lett. 2005 Dec 1;15(23):5120-3. DMXECFJ RU https://pubmed.ncbi.nlm.nih.gov/16202582 DM5N6YE DI DM5N6YE DM5N6YE DN Bbs-Arg-(D-Pip)-Gly-S-(GS)13-Gly-Hir DM5N6YE MI TT6L509 DM5N6YE MN Coagulation factor IIa (F2) DM5N6YE MT DTT DM5N6YE MA Inhibitor DM5N6YE RN Transforming bivalent ligands into retractable enzyme inhibitors through polypeptide-protein interactions. Bioorg Med Chem Lett. 2005 Dec 1;15(23):5120-3. DM5N6YE RU https://pubmed.ncbi.nlm.nih.gov/16202582 DMTU0HR DI DMTU0HR DMTU0HR DN Bbs-Arg-(D-Pip)-Gly-S-(GS)1-Gly-Hir DMTU0HR MI TT6L509 DMTU0HR MN Coagulation factor IIa (F2) DMTU0HR MT DTT DMTU0HR MA Inhibitor DMTU0HR RN Transforming bivalent ligands into retractable enzyme inhibitors through polypeptide-protein interactions. Bioorg Med Chem Lett. 2005 Dec 1;15(23):5120-3. DMTU0HR RU https://pubmed.ncbi.nlm.nih.gov/16202582 DMEL2GK DI DMEL2GK DMEL2GK DN Bbs-Arg-(D-Pip)-Gly-S-(GS)3-Gly-Hir DMEL2GK MI TT6L509 DMEL2GK MN Coagulation factor IIa (F2) DMEL2GK MT DTT DMEL2GK MA Inhibitor DMEL2GK RN Transforming bivalent ligands into retractable enzyme inhibitors through polypeptide-protein interactions. Bioorg Med Chem Lett. 2005 Dec 1;15(23):5120-3. DMEL2GK RU https://pubmed.ncbi.nlm.nih.gov/16202582 DMCN48J DI DMCN48J DMCN48J DN Bbs-Arg-(D-Pip)-Gly-S-(GS)5-Gly-Hir DMCN48J MI TT6L509 DMCN48J MN Coagulation factor IIa (F2) DMCN48J MT DTT DMCN48J MA Inhibitor DMCN48J RN Transforming bivalent ligands into retractable enzyme inhibitors through polypeptide-protein interactions. Bioorg Med Chem Lett. 2005 Dec 1;15(23):5120-3. DMCN48J RU https://pubmed.ncbi.nlm.nih.gov/16202582 DMLK5I0 DI DMLK5I0 DMLK5I0 DN Bbs-Arg-(D-Pip)-Gly-S-(GS)7-Gly-Hir DMLK5I0 MI TT6L509 DMLK5I0 MN Coagulation factor IIa (F2) DMLK5I0 MT DTT DMLK5I0 MA Inhibitor DMLK5I0 RN Transforming bivalent ligands into retractable enzyme inhibitors through polypeptide-protein interactions. Bioorg Med Chem Lett. 2005 Dec 1;15(23):5120-3. DMLK5I0 RU https://pubmed.ncbi.nlm.nih.gov/16202582 DMLZ5R6 DI DMLZ5R6 DMLZ5R6 DN Bbs-Arg-(D-Pip)-Gly-S-(GS)9-Gly-Hir DMLZ5R6 MI TT6L509 DMLZ5R6 MN Coagulation factor IIa (F2) DMLZ5R6 MT DTT DMLZ5R6 MA Inhibitor DMLZ5R6 RN Transforming bivalent ligands into retractable enzyme inhibitors through polypeptide-protein interactions. Bioorg Med Chem Lett. 2005 Dec 1;15(23):5120-3. DMLZ5R6 RU https://pubmed.ncbi.nlm.nih.gov/16202582 DMT0X6Q DI DMT0X6Q DMT0X6Q DN BBT-007 DMT0X6Q MI TT6MP2Z DMT0X6Q MN GMCSFR-alpha (CSF2RA) DMT0X6Q MT DTT DMT0X6Q MA Stimulator DMT0X6Q RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1707). DMT0X6Q RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1707 DM2YTXL DI DM2YTXL DM2YTXL DN BBT-009 DM2YTXL MI TTAUX24 DM2YTXL MN Erythropoietin Receptor (EPOR) DM2YTXL MT DTT DM2YTXL MA Stimulator DM2YTXL RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1718). DM2YTXL RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1718 DMLIT84 DI DMLIT84 DMLIT84 DN BBT-021 DMLIT84 MI TTAUX24 DMLIT84 MN Erythropoietin Receptor (EPOR) DMLIT84 MT DTT DMLIT84 MA Stimulator DMLIT84 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1718). DMLIT84 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1718 DMQNA7V DI DMQNA7V DMQNA7V DN BC11-38 DMQNA7V MI TTTWC79 DMQNA7V MN Phosphodiesterase 11A (PDE11A) DMQNA7V MT DTT DMQNA7V MA Inhibitor DMQNA7V RN Identification of biologically active PDE11-selective inhibitors using a yeast-based high-throughput screen. Chem Biol. 2012 Jan 27;19(1):155-63. DMQNA7V RU https://pubmed.ncbi.nlm.nih.gov/22284362 DMQWOZ5 DI DMQWOZ5 DMQWOZ5 DN BC-264 DMQWOZ5 MI TTVFO0U DMQWOZ5 MN Gastrin/cholecystokinin type B receptor (CCKBR) DMQWOZ5 MT DTT DMQWOZ5 MA Agonist DMQWOZ5 RN Synthesis and biological characterisation of [3H]BBL454, a new CCK2 selective radiolabelled agonist displaying original pharmacological properties. Bioorg Med Chem Lett. 2004 Jan 19;14(2):369-72. DMQWOZ5 RU https://pubmed.ncbi.nlm.nih.gov/14698161 DM047DQ DI DM047DQ DM047DQ DN BCEAB DM047DQ MI TT8VUE0 DM047DQ MN Chymase (CYM) DM047DQ MT DTT DM047DQ MA Inhibitor DM047DQ RN Development of a chymase inhibitor: pharmacological characterization of a chymase inhibitor in inflamed tissue remodeling and fibrosis. Jpn J Pharmacol. 2002 Nov;90(3):206-9. DM047DQ RU https://pubmed.ncbi.nlm.nih.gov/12499572 DMPG1LJ DI DMPG1LJ DMPG1LJ DN Bcecf-Am DMPG1LJ MI DTUGYRD DMPG1LJ MN P-glycoprotein 1 (ABCB1) DMPG1LJ MT DTP DMPG1LJ MA Substrate DMPG1LJ RN Mammalian drug efflux transporters of the ATP binding cassette (ABC) family in multidrug resistance: A review of the past decade. Cancer Lett. 2016 Jan 1;370(1):153-64. DMPG1LJ RU http://www.ncbi.nlm.nih.gov/pubmed/26499806 DM9IN0U DI DM9IN0U DM9IN0U DN BCH DM9IN0U MI TTPH2JB DM9IN0U MN Large neutral amino acids transporter 1 (SLC7A5) DM9IN0U MT DTT DM9IN0U MA Blocker DM9IN0U RN Amino acid transporter molecule as a drug target. Nippon Yakurigaku Zasshi. 1999 Oct;114 Suppl 1:11P-16P. DM9IN0U RU https://pubmed.ncbi.nlm.nih.gov/10629848 DMT5AGJ DI DMT5AGJ DMT5AGJ DN BCTC DMT5AGJ MI TTMI6F5 DMT5AGJ MN Transient receptor potential cation channel V1 (TRPV1) DMT5AGJ MT DTT DMT5AGJ MA Blocker DMT5AGJ RN Analgesic potential of TRPV1 antagonists. Biochem Pharmacol. 2009 Aug 1;78(3):211-6. DMT5AGJ RU https://pubmed.ncbi.nlm.nih.gov/19481638 DMVOS2C DI DMVOS2C DMVOS2C DN BCX-1827 DMVOS2C MI TT50QJ3 DMVOS2C MN Influenza Neuraminidase (Influ NA) DMVOS2C MT DTT DMVOS2C MA Inhibitor DMVOS2C RN Antiviral agents active against influenza A viruses. Nat Rev Drug Discov. 2006 Dec;5(12):1015-25. DMVOS2C RU https://pubmed.ncbi.nlm.nih.gov/17139286 DM6JB32 DI DM6JB32 DM6JB32 DN BCX-1898 DM6JB32 MI TT50QJ3 DM6JB32 MN Influenza Neuraminidase (Influ NA) DM6JB32 MT DTT DM6JB32 MA Inhibitor DM6JB32 RN Antiviral agents active against influenza A viruses. Nat Rev Drug Discov. 2006 Dec;5(12):1015-25. DM6JB32 RU https://pubmed.ncbi.nlm.nih.gov/17139286 DM8G4HS DI DM8G4HS DM8G4HS DN BCX-1923 DM8G4HS MI TT50QJ3 DM8G4HS MN Influenza Neuraminidase (Influ NA) DM8G4HS MT DTT DM8G4HS MA Inhibitor DM8G4HS RN Antiviral agents active against influenza A viruses. Nat Rev Drug Discov. 2006 Dec;5(12):1015-25. DM8G4HS RU https://pubmed.ncbi.nlm.nih.gov/17139286 DMFIDA0 DI DMFIDA0 DMFIDA0 DN BD-1047 DMFIDA0 MI TT5TPI6 DMFIDA0 MN Opioid receptor sigma 1 (OPRS1) DMFIDA0 MT DTT DMFIDA0 MA Antagonist DMFIDA0 RN Characterization of two novel sigma receptor ligands: antidystonic effects in rats suggest sigma receptor antagonism. Eur J Pharmacol. 1995 Jul 14;280(3):301-10. DMFIDA0 RU https://pubmed.ncbi.nlm.nih.gov/8566098 DMT0S7M DI DMT0S7M DMT0S7M DN BD-NP DMT0S7M MI TTY63XT DMT0S7M MN B-type natriuretic peptide (BNP) DMT0S7M MT DTT DMT0S7M MA Modulator DMT0S7M RN A Novel Designer Natriuretic and Diuretic Peptide Based Upon an Alternatively Spliced BNP Without Vascular Vasodilatory Actions. Circulation, 2006, 114:II_270. DMT0S7M RU http://circ.ahajournals.org/cgi/content/meeting_abstract/114/18_MeetingAbstracts/II_270-a DMZX57Y DI DMZX57Y DMZX57Y DN befetupitant DMZX57Y MI TTZPO1L DMZX57Y MN Substance-P receptor (TACR1) DMZX57Y MT DTT DMZX57Y MA Antagonist DMZX57Y RN Design and synthesis of a novel, achiral class of highly potent and selective, orally active neurokinin-1 receptor antagonists. Bioorg Med Chem Lett. 2006 Mar 1;16(5):1362-5. DMZX57Y RU https://pubmed.ncbi.nlm.nih.gov/16332435 DMV15JC DI DMV15JC DMV15JC DN Befunolol DMV15JC MI DECB0K3 DMV15JC MN Cytochrome P450 2D6 (CYP2D6) DMV15JC MT DME DMV15JC MA Metabolism DMV15JC RN Application of substrate depletion assay to evaluation of CYP isoforms responsible for stereoselective metabolism of carvedilol. Drug Metab Pharmacokinet. 2016 Dec;31(6):425-432. DMV15JC RU https://www.ncbi.nlm.nih.gov/pubmed/?term=27836712 DM0WOS6 DI DM0WOS6 DM0WOS6 DN BELFOSDIL DM0WOS6 MI TT5HONZ DM0WOS6 MN Calcium channel unspecific (CaC) DM0WOS6 MT DTT DM0WOS6 MA Modulator DM0WOS6 RN Determination of belfosdil, a new calcium channel blocker, in human plasma by capillary gas chromatography with nitrogen-phosphorus detection. J Chromatogr. 1990 May 18;527(2):343-50. DM0WOS6 RU https://www.ncbi.nlm.nih.gov/pubmed/2387881 DM7H3VY DI DM7H3VY DM7H3VY DN Bencyclane DM7H3VY MI DE4LYSA DM7H3VY MN Cytochrome P450 3A4 (CYP3A4) DM7H3VY MT DME DM7H3VY MA Metabolism DM7H3VY RN Integrated analysis on the physicochemical properties of dihydropyridine calcium channel blockers in grapefruit juice interactions. Curr Pharm Biotechnol. 2012 Jul;13(9):1705-17. DM7H3VY RU https://www.ncbi.nlm.nih.gov/pubmed/?term=22039822 DMFPSOQ DI DMFPSOQ DMFPSOQ DN Benzaldehyde O-4-(decyloxy)phenylcarbamoyl oxime DMFPSOQ MI TTDP1UC DMFPSOQ MN Fatty acid amide hydrolase (FAAH) DMFPSOQ MT DTT DMFPSOQ MA Inhibitor DMFPSOQ RN Oxime carbamate--discovery of a series of novel FAAH inhibitors. Bioorg Med Chem Lett. 2010 Feb 1;20(3):1272-7. DMFPSOQ RU https://pubmed.ncbi.nlm.nih.gov/20036536 DMU7INH DI DMU7INH DMU7INH DN Benzaldehyde O-4-(heptyloxy)phenylcarbamoyl oxime DMU7INH MI TTDP1UC DMU7INH MN Fatty acid amide hydrolase (FAAH) DMU7INH MT DTT DMU7INH MA Inhibitor DMU7INH RN Oxime carbamate--discovery of a series of novel FAAH inhibitors. Bioorg Med Chem Lett. 2010 Feb 1;20(3):1272-7. DMU7INH RU https://pubmed.ncbi.nlm.nih.gov/20036536 DMOK0U8 DI DMOK0U8 DMOK0U8 DN Benzaldehyde O-4-(hexyloxy)phenylcarbamoyl oxime DMOK0U8 MI TTDP1UC DMOK0U8 MN Fatty acid amide hydrolase (FAAH) DMOK0U8 MT DTT DMOK0U8 MA Inhibitor DMOK0U8 RN Oxime carbamate--discovery of a series of novel FAAH inhibitors. Bioorg Med Chem Lett. 2010 Feb 1;20(3):1272-7. DMOK0U8 RU https://pubmed.ncbi.nlm.nih.gov/20036536 DMIV3S8 DI DMIV3S8 DMIV3S8 DN Benzaldehyde O-4-(nonyloxy)phenylcarbamoyl oxime DMIV3S8 MI TTDP1UC DMIV3S8 MN Fatty acid amide hydrolase (FAAH) DMIV3S8 MT DTT DMIV3S8 MA Inhibitor DMIV3S8 RN Oxime carbamate--discovery of a series of novel FAAH inhibitors. Bioorg Med Chem Lett. 2010 Feb 1;20(3):1272-7. DMIV3S8 RU https://pubmed.ncbi.nlm.nih.gov/20036536 DMBW7PX DI DMBW7PX DMBW7PX DN Benzaldehyde O-4-(octyloxy)phenylcarbamoyl oxime DMBW7PX MI TTDP1UC DMBW7PX MN Fatty acid amide hydrolase (FAAH) DMBW7PX MT DTT DMBW7PX MA Inhibitor DMBW7PX RN Oxime carbamate--discovery of a series of novel FAAH inhibitors. Bioorg Med Chem Lett. 2010 Feb 1;20(3):1272-7. DMBW7PX RU https://pubmed.ncbi.nlm.nih.gov/20036536 DMWEXOY DI DMWEXOY DMWEXOY DN Benzaldehyde O-4-(pentyloxy)phenylcarbamoyl oxime DMWEXOY MI TTDP1UC DMWEXOY MN Fatty acid amide hydrolase (FAAH) DMWEXOY MT DTT DMWEXOY MA Inhibitor DMWEXOY RN Oxime carbamate--discovery of a series of novel FAAH inhibitors. Bioorg Med Chem Lett. 2010 Feb 1;20(3):1272-7. DMWEXOY RU https://pubmed.ncbi.nlm.nih.gov/20036536 DMHUQWN DI DMHUQWN DMHUQWN DN Benzaldehyde O-4-butoxyphenylcarbamoyl oxime DMHUQWN MI TTDP1UC DMHUQWN MN Fatty acid amide hydrolase (FAAH) DMHUQWN MT DTT DMHUQWN MA Inhibitor DMHUQWN RN Oxime carbamate--discovery of a series of novel FAAH inhibitors. Bioorg Med Chem Lett. 2010 Feb 1;20(3):1272-7. DMHUQWN RU https://pubmed.ncbi.nlm.nih.gov/20036536 DMD98YP DI DMD98YP DMD98YP DN Benzaldehyde O-4-ethoxyphenylcarbamoyl oxime DMD98YP MI TTDP1UC DMD98YP MN Fatty acid amide hydrolase (FAAH) DMD98YP MT DTT DMD98YP MA Inhibitor DMD98YP RN Oxime carbamate--discovery of a series of novel FAAH inhibitors. Bioorg Med Chem Lett. 2010 Feb 1;20(3):1272-7. DMD98YP RU https://pubmed.ncbi.nlm.nih.gov/20036536 DMLHKQS DI DMLHKQS DMLHKQS DN Benzaldehyde O-4-methoxyphenylcarbamoyl oxime DMLHKQS MI TTDP1UC DMLHKQS MN Fatty acid amide hydrolase (FAAH) DMLHKQS MT DTT DMLHKQS MA Inhibitor DMLHKQS RN Oxime carbamate--discovery of a series of novel FAAH inhibitors. Bioorg Med Chem Lett. 2010 Feb 1;20(3):1272-7. DMLHKQS RU https://pubmed.ncbi.nlm.nih.gov/20036536 DMARBF9 DI DMARBF9 DMARBF9 DN Benzaldehyde O-4-propoxyphenylcarbamoyl oxime DMARBF9 MI TTDP1UC DMARBF9 MN Fatty acid amide hydrolase (FAAH) DMARBF9 MT DTT DMARBF9 MA Inhibitor DMARBF9 RN Oxime carbamate--discovery of a series of novel FAAH inhibitors. Bioorg Med Chem Lett. 2010 Feb 1;20(3):1272-7. DMARBF9 RU https://pubmed.ncbi.nlm.nih.gov/20036536 DMB7DFT DI DMB7DFT DMB7DFT DN Benzaldehyde O-benzoyloxime DMB7DFT MI TTDNFMT DMB7DFT MN Platelet-activating factor acetylhydrolase (PLA2G7) DMB7DFT MT DTT DMB7DFT MA Inhibitor DMB7DFT RN Potent inhibitors of lipoprotein-associated phospholipase A(2): benzaldehyde O-heterocycle-4-carbonyloxime. Bioorg Med Chem Lett. 2006 Nov 1;16(21):5576-9. DMB7DFT RU https://pubmed.ncbi.nlm.nih.gov/16919943 DM37GWL DI DM37GWL DM37GWL DN Benzamidine DM37GWL MI TT2WR1T DM37GWL MN Cationic trypsinogen (PRSS1) DM37GWL MT DTT DM37GWL MA Inhibitor DM37GWL RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DM37GWL RU https://pubmed.ncbi.nlm.nih.gov/17139284 DM37GWL DI DM37GWL DM37GWL DN Benzamidine DM37GWL MI TTLPF4X DM37GWL MN Kallikrein-6 (KLK6) DM37GWL MT DTT DM37GWL MA Inhibitor DM37GWL RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DM37GWL RU https://pubmed.ncbi.nlm.nih.gov/17139284 DM37GWL DI DM37GWL DM37GWL DN Benzamidine DM37GWL MI TTPRO7W DM37GWL MN Suppressor of tumorigenicity 14 protein (ST14) DM37GWL MT DTT DM37GWL MA Inhibitor DM37GWL RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DM37GWL RU https://pubmed.ncbi.nlm.nih.gov/17139284 DM37GWL DI DM37GWL DM37GWL DN Benzamidine DM37GWL MI TTGY7WI DM37GWL MN Urokinase-type plasminogen activator (PLAU) DM37GWL MT DTT DM37GWL MA Inhibitor DM37GWL RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DM37GWL RU https://pubmed.ncbi.nlm.nih.gov/17139284 DM57SVW DI DM57SVW DM57SVW DN Benzamil DM57SVW MI TTLGDIS DM57SVW MN Acid-sensing ion channel 3 (ASIC3) DM57SVW MT DTT DM57SVW MA Blocker (channel blocker) DM57SVW RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 684). DM57SVW RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=684 DM57SVW DI DM57SVW DM57SVW DN Benzamil DM57SVW MI TTQM7TE DM57SVW MN Amiloride-sensitive sodium channel (ENaC) DM57SVW MT DTT DM57SVW MA Blocker (channel blocker) DM57SVW RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 742). DM57SVW RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=742 DM57SVW DI DM57SVW DM57SVW DN Benzamil DM57SVW MI DTT79CX DM57SVW MN Organic cation transporter 1 (SLC22A1) DM57SVW MT DTP DM57SVW MA Substrate DM57SVW RN Identification of novel substrates and structure-activity relationship of cellular uptake mediated by human organic cation transporters 1 and 2. J Med Chem. 2013 Sep 26;56(18):7232-42. DM57SVW RU http://www.ncbi.nlm.nih.gov/pubmed/23984907 DM57SVW DI DM57SVW DM57SVW DN Benzamil DM57SVW MI TTAHD89 DM57SVW MN Polycystic kidney disease 2-like 1 (TRPP2) DM57SVW MT DTT DM57SVW MA Blocker (channel blocker) DM57SVW RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 505). DM57SVW RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=505 DMK5QYW DI DMK5QYW DMK5QYW DN BENZENEMETHANETHIOL DMK5QYW MI TTZJYKH DMK5QYW MN Indoleamine 2,3-dioxygenase 1 (IDO1) DMK5QYW MT DTT DMK5QYW MA Inhibitor DMK5QYW RN S-benzylisothiourea derivatives as small-molecule inhibitors of indoleamine-2,3-dioxygenase. Bioorg Med Chem Lett. 2010 Sep 1;20(17):5126-9. DMK5QYW RU https://pubmed.ncbi.nlm.nih.gov/20688518 DM3I8A1 DI DM3I8A1 DM3I8A1 DN BENZENESULFONAMIDE DM3I8A1 MI TTHQPL7 DM3I8A1 MN Carbonic anhydrase I (CA-I) DM3I8A1 MT DTT DM3I8A1 MA Inhibitor DM3I8A1 RN Ligand-directed tosyl chemistry for protein labeling in vivo. Nat Chem Biol. 2009 May;5(5):341-3. DM3I8A1 RU https://pubmed.ncbi.nlm.nih.gov/19330012 DMMBYGE DI DMMBYGE DMMBYGE DN Benzenesulfonyl DMMBYGE MI TTXA6PH DMMBYGE MN Oxysterols receptor LXR-beta (NR1H2) DMMBYGE MT DTT DMMBYGE MA Inhibitor DMMBYGE RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMMBYGE RU https://pubmed.ncbi.nlm.nih.gov/17139284 DM5Y2M8 DI DM5Y2M8 DM5Y2M8 DN BENZIL DM5Y2M8 MI TTMF541 DM5Y2M8 MN Liver carboxylesterase (CES1) DM5Y2M8 MT DTT DM5Y2M8 MA Inhibitor DM5Y2M8 RN Influence of sulfur oxidation state and steric bulk upon trifluoromethyl ketone (TFK) binding kinetics to carboxylesterases and fatty acid amide hy... Bioorg Med Chem. 2008 Feb 15;16(4):2114-30. DM5Y2M8 RU https://pubmed.ncbi.nlm.nih.gov/18023188 DM75U9X DI DM75U9X DM75U9X DN Benzimidazole 5-carboxamide DM75U9X MI TT84ETX DM75U9X MN Human immunodeficiency virus Reverse transcriptase (HIV RT) DM75U9X MT DTT DM75U9X MA Inhibitor DM75U9X RN Emerging antiviral drugs. Expert Opin Emerg Drugs. 2008 Sep;13(3):393-416. DM75U9X RU https://pubmed.ncbi.nlm.nih.gov/18764719 DM067NL DI DM067NL DM067NL DN Benzo[1,3]dioxol-5-ylmethyl-quinazolin-4-yl-amine DM067NL MI TTJ0IQB DM067NL MN Phosphodiesterase 5A (PDE5A) DM067NL MT DTT DM067NL MA Inhibitor DM067NL RN Cyclic GMP phosphodiesterase inhibitors. 2. Requirement of 6-substitution of quinazoline derivatives for potent and selective inhibitory activity. J Med Chem. 1994 Jun 24;37(13):2106-11. DM067NL RU https://pubmed.ncbi.nlm.nih.gov/8027992 DMJQSLW DI DMJQSLW DMJQSLW DN Benzo[b]thiophen-2-ylboronic acid DMJQSLW MI TTDP1UC DMJQSLW MN Fatty acid amide hydrolase (FAAH) DMJQSLW MT DTT DMJQSLW MA Inhibitor DMJQSLW RN Discovery of boronic acids as novel and potent inhibitors of fatty acid amide hydrolase. J Med Chem. 2008 Nov 27;51(22):7057-60. DMJQSLW RU https://pubmed.ncbi.nlm.nih.gov/18983140 DMJQSLW DI DMJQSLW DMJQSLW DN Benzo[b]thiophen-2-ylboronic acid DMJQSLW MI TTHI19T DMJQSLW MN Staphylococcus Beta-lactamase (Stap-coc blaZ) DMJQSLW MT DTT DMJQSLW MA Inhibitor DMJQSLW RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMJQSLW RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMZR02J DI DMZR02J DMZR02J DN Benzo[c][1,2]oxaborol-1(3H)-ol DMZR02J MI TTLP6GN DMZR02J MN Bacterial DD-carboxypeptidase (Bact vanYB) DMZR02J MT DTT DMZR02J MA Inhibitor DMZR02J RN Synthesis and evaluation of 3-(dihydroxyboryl)benzoic acids as D,D-carboxypeptidase R39 inhibitors. J Med Chem. 2009 Oct 8;52(19):6097-106. DMZR02J RU https://pubmed.ncbi.nlm.nih.gov/19731939 DMMYGB9 DI DMMYGB9 DMMYGB9 DN Benzo[c][1,5]naphthyridin-6(5H)-one DMMYGB9 MI TTVDSZ0 DMMYGB9 MN Poly [ADP-ribose] polymerase 1 (PARP1) DMMYGB9 MT DTT DMMYGB9 MA Inhibitor DMMYGB9 RN Design, synthesis, and cytoprotective effect of 2-aminothiazole analogues as potent poly(ADP-ribose) polymerase-1 inhibitors. J Med Chem. 2009 Feb 12;52(3):718-25. DMMYGB9 RU https://pubmed.ncbi.nlm.nih.gov/19125579 DMISHTB DI DMISHTB DMISHTB DN Benzo[g]quinazolin-4-yl-(3-bromo-phenyl)-amine DMISHTB MI TTGKNB4 DMISHTB MN Epidermal growth factor receptor (EGFR) DMISHTB MT DTT DMISHTB MA Inhibitor DMISHTB RN Tyrosine kinase inhibitors. 9. Synthesis and evaluation of fused tricyclic quinazoline analogues as ATP site inhibitors of the tyrosine kinase acti... J Med Chem. 1996 Feb 16;39(4):918-28. DMISHTB RU https://pubmed.ncbi.nlm.nih.gov/8632415 DM9H34M DI DM9H34M DM9H34M DN Benzodiazepine DM9H34M MI DE4LYSA DM9H34M MN Cytochrome P450 3A4 (CYP3A4) DM9H34M MT DME DM9H34M MA Metabolism DM9H34M RN Summary of information on human CYP enzymes: human P450 metabolism data. Drug Metab Rev. 2002 Feb-May;34(1-2):83-448. DM9H34M RU https://www.ncbi.nlm.nih.gov/pubmed/?term=11996015 DM9H34M DI DM9H34M DM9H34M DN Benzodiazepine DM9H34M MI TTPTXIN DM9H34M MN Translocator protein (TSPO) DM9H34M MT DTT DM9H34M MA Agonist DM9H34M RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2879). DM9H34M RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2879 DMF1ZE6 DI DMF1ZE6 DMF1ZE6 DN Benzofuran-2-yl(indolin-1-yl)methanone DMF1ZE6 MI TT6804T DMF1ZE6 MN MIF messenger RNA (MIF mRNA) DMF1ZE6 MT DTT DMF1ZE6 MA Inhibitor DMF1ZE6 RN Discovery of human macrophage migration inhibitory factor (MIF)-CD74 antagonists via virtual screening. J Med Chem. 2009 Jan 22;52(2):416-24. DMF1ZE6 RU https://pubmed.ncbi.nlm.nih.gov/19090668 DMQ7I06 DI DMQ7I06 DMQ7I06 DN Benzofuran-2-ylboronic acid DMQ7I06 MI TTDP1UC DMQ7I06 MN Fatty acid amide hydrolase (FAAH) DMQ7I06 MT DTT DMQ7I06 MA Inhibitor DMQ7I06 RN Discovery of boronic acids as novel and potent inhibitors of fatty acid amide hydrolase. J Med Chem. 2008 Nov 27;51(22):7057-60. DMQ7I06 RU https://pubmed.ncbi.nlm.nih.gov/18983140 DMNVG1M DI DMNVG1M DMNVG1M DN Benzofuran-3-yl-(indol-3-yl)maleimides DMNVG1M MI TTRZQE3 DMNVG1M MN Glycogen synthase kinase-3 alpha (GSK-3A) DMNVG1M MT DTT DMNVG1M MA Inhibitor DMNVG1M RN From a natural product lead to the identification of potent and selective benzofuran-3-yl-(indol-3-yl)maleimides as glycogen synthase kinase 3beta inhibitors that suppress proliferation and survival of pancreatic cancer cells. J Med Chem. 2009 Apr 9;52(7):1853-63. DMNVG1M RU https://pubmed.ncbi.nlm.nih.gov/19338355 DMAQK0G DI DMAQK0G DMAQK0G DN Benzoic acid 2,6-diisopropyl-phenyl ester DMAQK0G MI TTNJYV2 DMAQK0G MN Gamma-aminobutyric acid receptor (GAR) DMAQK0G MT DTT DMAQK0G MA Inhibitor DMAQK0G RN Propofol analogues. Synthesis, relationships between structure and affinity at GABAA receptor in rat brain, and differential electrophysiological p... J Med Chem. 1998 May 21;41(11):1846-54. DMAQK0G RU https://pubmed.ncbi.nlm.nih.gov/9599235 DM6T8YM DI DM6T8YM DM6T8YM DN Benzoic acid 8-aza-bicyclo[3.2.1]oct-6-yl ester DM6T8YM MI TTZ9SOR DM6T8YM MN Muscarinic acetylcholine receptor M1 (CHRM1) DM6T8YM MT DTT DM6T8YM MA Inhibitor DM6T8YM RN 6beta-Acyloxy(nor)tropanes: affinities for antagonist/agonist binding sites on transfected and native muscarinic receptors. J Med Chem. 2000 Jun 29;43(13):2514-22. DM6T8YM RU https://pubmed.ncbi.nlm.nih.gov/10891110 DM6T8YM DI DM6T8YM DM6T8YM DN Benzoic acid 8-aza-bicyclo[3.2.1]oct-6-yl ester DM6T8YM MI TTYEG6Q DM6T8YM MN Muscarinic acetylcholine receptor M2 (CHRM2) DM6T8YM MT DTT DM6T8YM MA Inhibitor DM6T8YM RN 6beta-Acyloxy(nor)tropanes: affinities for antagonist/agonist binding sites on transfected and native muscarinic receptors. J Med Chem. 2000 Jun 29;43(13):2514-22. DM6T8YM RU https://pubmed.ncbi.nlm.nih.gov/10891110 DM6T8YM DI DM6T8YM DM6T8YM DN Benzoic acid 8-aza-bicyclo[3.2.1]oct-6-yl ester DM6T8YM MI TTQ13Z5 DM6T8YM MN Muscarinic acetylcholine receptor M3 (CHRM3) DM6T8YM MT DTT DM6T8YM MA Inhibitor DM6T8YM RN 6beta-Acyloxy(nor)tropanes: affinities for antagonist/agonist binding sites on transfected and native muscarinic receptors. J Med Chem. 2000 Jun 29;43(13):2514-22. DM6T8YM RU https://pubmed.ncbi.nlm.nih.gov/10891110 DM6T8YM DI DM6T8YM DM6T8YM DN Benzoic acid 8-aza-bicyclo[3.2.1]oct-6-yl ester DM6T8YM MI TTQ3JTF DM6T8YM MN Muscarinic acetylcholine receptor M4 (CHRM4) DM6T8YM MT DTT DM6T8YM MA Inhibitor DM6T8YM RN 6beta-Acyloxy(nor)tropanes: affinities for antagonist/agonist binding sites on transfected and native muscarinic receptors. J Med Chem. 2000 Jun 29;43(13):2514-22. DM6T8YM RU https://pubmed.ncbi.nlm.nih.gov/10891110 DM6T8YM DI DM6T8YM DM6T8YM DN Benzoic acid 8-aza-bicyclo[3.2.1]oct-6-yl ester DM6T8YM MI TTH18TF DM6T8YM MN Muscarinic acetylcholine receptor M5 (CHRM5) DM6T8YM MT DTT DM6T8YM MA Inhibitor DM6T8YM RN 6beta-Acyloxy(nor)tropanes: affinities for antagonist/agonist binding sites on transfected and native muscarinic receptors. J Med Chem. 2000 Jun 29;43(13):2514-22. DM6T8YM RU https://pubmed.ncbi.nlm.nih.gov/10891110 DM50QMB DI DM50QMB DM50QMB DN Benzoin DM50QMB MI TTMF541 DM50QMB MN Liver carboxylesterase (CES1) DM50QMB MT DTT DM50QMB MA Inhibitor DM50QMB RN Analysis of the inhibition of mammalian carboxylesterases by novel fluorobenzoins and fluorobenzils. Bioorg Med Chem. 2007 Jun 1;15(11):3801-17. DM50QMB RU https://pubmed.ncbi.nlm.nih.gov/17399985 DME5QPX DI DME5QPX DME5QPX DN BENZOLAMIDE DME5QPX MI TTUNARX DME5QPX MN Carbonic anhydrase (CA) DME5QPX MT DTT DME5QPX MA Inhibitor DME5QPX RN Cloning, expression, post-translational modifications and inhibition studies on the latest mammalian carbonic anhydrase isoform, CA XV. J Med Chem. 2009 Feb 12;52(3):646-54. DME5QPX RU https://pubmed.ncbi.nlm.nih.gov/19193158 DME5QPX DI DME5QPX DME5QPX DN BENZOLAMIDE DME5QPX MI TTHQPL7 DME5QPX MN Carbonic anhydrase I (CA-I) DME5QPX MT DTT DME5QPX MA Inhibitor DME5QPX RN Carbonic anhydrase inhibitors. Inhibition studies of a coral secretory isoform by sulfonamides. Bioorg Med Chem. 2009 Jul 15;17(14):5054-8. DME5QPX RU https://pubmed.ncbi.nlm.nih.gov/19520577 DME5QPX DI DME5QPX DME5QPX DN BENZOLAMIDE DME5QPX MI TTANPDJ DME5QPX MN Carbonic anhydrase II (CA-II) DME5QPX MT DTT DME5QPX MA Inhibitor DME5QPX RN Carbonic anhydrase inhibitors. Characterization and inhibition studies of the most active beta-carbonic anhydrase from Mycobacterium tuberculosis, ... Bioorg Med Chem Lett. 2009 Dec 1;19(23):6649-54. DME5QPX RU https://pubmed.ncbi.nlm.nih.gov/19846301 DME5QPX DI DME5QPX DME5QPX DN BENZOLAMIDE DME5QPX MI TTZHA0O DME5QPX MN Carbonic anhydrase IV (CA-IV) DME5QPX MT DTT DME5QPX MA Inhibitor DME5QPX RN Carbonic anhydrase inhibitors: topically acting antiglaucoma sulfonamides incorporating esters and amides of 3- and 4-carboxybenzolamide. Bioorg Med Chem Lett. 2003 Sep 1;13(17):2867-73. DME5QPX RU https://pubmed.ncbi.nlm.nih.gov/14611846 DME5QPX DI DME5QPX DME5QPX DN BENZOLAMIDE DME5QPX MI TT2LVK8 DME5QPX MN Carbonic anhydrase IX (CA-IX) DME5QPX MT DTT DME5QPX MA Inhibitor DME5QPX RN Cloning, expression, post-translational modifications and inhibition studies on the latest mammalian carbonic anhydrase isoform, CA XV. J Med Chem. 2009 Feb 12;52(3):646-54. DME5QPX RU https://pubmed.ncbi.nlm.nih.gov/19193158 DME5QPX DI DME5QPX DME5QPX DN BENZOLAMIDE DME5QPX MI TTCFSPE DME5QPX MN Carbonic anhydrase VI (CA-VI) DME5QPX MT DTT DME5QPX MA Inhibitor DME5QPX RN Cloning, expression, post-translational modifications and inhibition studies on the latest mammalian carbonic anhydrase isoform, CA XV. J Med Chem. 2009 Feb 12;52(3):646-54. DME5QPX RU https://pubmed.ncbi.nlm.nih.gov/19193158 DME5QPX DI DME5QPX DME5QPX DN BENZOLAMIDE DME5QPX MI TTSYM0R DME5QPX MN Carbonic anhydrase XII (CA-XII) DME5QPX MT DTT DME5QPX MA Inhibitor DME5QPX RN Carbonic anhydrase inhibitors. Inhibition of the transmembrane isozyme XII with sulfonamides-a new target for the design of antitumor and antiglauc... Bioorg Med Chem Lett. 2005 Feb 15;15(4):963-9. DME5QPX RU https://pubmed.ncbi.nlm.nih.gov/15686894 DME5QPX DI DME5QPX DME5QPX DN BENZOLAMIDE DME5QPX MI TTEYTKG DME5QPX MN Carbonic anhydrase XIV (CA-XIV) DME5QPX MT DTT DME5QPX MA Inhibitor DME5QPX RN Carbonic anhydrase inhibitors: inhibition of the transmembrane isozyme XIV with sulfonamides. Bioorg Med Chem Lett. 2005 Sep 1;15(17):3828-33. DME5QPX RU https://pubmed.ncbi.nlm.nih.gov/16039848 DMRE96F DI DMRE96F DMRE96F DN Benzomate DMRE96F MI TTHM0R1 DMRE96F MN Steryl-sulfatase (STS) DMRE96F MT DTT DMRE96F MA Inhibitor DMRE96F RN Synthesis, in vitro and in vivo activity of benzophenone-based inhibitors of steroid sulfatase. Bioorg Med Chem. 2004 May 15;12(10):2759-72. DMRE96F RU https://pubmed.ncbi.nlm.nih.gov/15110857 DMMKBFN DI DMMKBFN DMMKBFN DN benzoquinazolinone 12 DMMKBFN MI TTOXS3C DMMKBFN MN Muscarinic acetylcholine receptor (CHRM) DMMKBFN MT DTT DMMKBFN MA Modulator (allosteric modulator) DMMKBFN RN Mechanistic insights into allosteric structure-function relationships at the M1 muscarinic acetylcholine receptor. J Biol Chem. 2014 Nov 28;289(48):33701-11. DMMKBFN RU https://pubmed.ncbi.nlm.nih.gov/25326383 DMNBA0G DI DMNBA0G DMNBA0G DN Benzoquinone DMNBA0G MI TT1RS9F DMNBA0G MN Acetylcholinesterase (AChE) DMNBA0G MT DTT DMNBA0G MA Inhibitor DMNBA0G RN Identification and characterization of novel benzil (diphenylethane-1,2-dione) analogues as inhibitors of mammalian carboxylesterases. J Med Chem. 2005 Apr 21;48(8):2906-15. DMNBA0G RU https://pubmed.ncbi.nlm.nih.gov/15828829 DMNBA0G DI DMNBA0G DMNBA0G DN Benzoquinone DMNBA0G MI TTEB0GD DMNBA0G MN Cholinesterase (BCHE) DMNBA0G MT DTT DMNBA0G MA Inhibitor DMNBA0G RN Identification and characterization of novel benzil (diphenylethane-1,2-dione) analogues as inhibitors of mammalian carboxylesterases. J Med Chem. 2005 Apr 21;48(8):2906-15. DMNBA0G RU https://pubmed.ncbi.nlm.nih.gov/15828829 DMNBA0G DI DMNBA0G DMNBA0G DN Benzoquinone DMNBA0G MI DEAN5EW DMNBA0G MN Nitroreductase (NTR) DMNBA0G MT DME DMNBA0G MA Metabolism DMNBA0G RN Overexpression, isotopic labeling, and spectral characterization of Enterobacter cloacae nitroreductase. Protein Expr Purif. 1998 Jun;13(1):53-60. DMNBA0G RU https://pubmed.ncbi.nlm.nih.gov/9631515 DMNBA0G DI DMNBA0G DMNBA0G DN Benzoquinone DMNBA0G MI DEKVGPX DMNBA0G MN Retro-nitroreductase (rNR) DMNBA0G MT DME DMNBA0G MA Metabolism DMNBA0G RN Retro-nitroreductase, a putative evolutionary precursor to Enterobacter cloacae strain 96-3 nitroreductase. Antioxid Redox Signal. 2001 Oct;3(5):747-55. DMNBA0G RU https://pubmed.ncbi.nlm.nih.gov/11761325 DMNBA0G DI DMNBA0G DMNBA0G DN Benzoquinone DMNBA0G MI DEGLTNR DMNBA0G MN Sulfide-quinone reductase (SQR) DMNBA0G MT DME DMNBA0G MA Metabolism DMNBA0G RN The quinone-binding site of Acidithiobacillus ferrooxidans sulfide: quinone oxidoreductase controls both sulfide oxidation and quinone reduction. Biochem Cell Biol. 2016 Apr;94(2):159-66. DMNBA0G RU https://pubmed.ncbi.nlm.nih.gov/26914540 DM4OKXI DI DM4OKXI DM4OKXI DN Benzotetronic acid DM4OKXI MI DE4LYSA DM4OKXI MN Cytochrome P450 3A4 (CYP3A4) DM4OKXI MT DME DM4OKXI MA Metabolism DM4OKXI RN CYP3A4 and CYP2A6 activities marked by the metabolism of lignocaine and coumarin in patients with liver and kidney diseases and epileptic patients. Br J Clin Pharmacol. 1995 Jan;39(1):71-6. DM4OKXI RU https://www.ncbi.nlm.nih.gov/pubmed/?term=7756103 DMV7MPL DI DMV7MPL DMV7MPL DN BENZOTHIAZOLE DMV7MPL MI TT6L509 DMV7MPL MN Coagulation factor IIa (F2) DMV7MPL MT DTT DMV7MPL MA Inhibitor DMV7MPL RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DMV7MPL RU https://pubmed.ncbi.nlm.nih.gov/10592235 DMROP5Q DI DMROP5Q DMROP5Q DN Benzothiazole-2-sulfonic acid amide DMROP5Q MI TTUNARX DMROP5Q MN Carbonic anhydrase (CA) DMROP5Q MT DTT DMROP5Q MA Inhibitor DMROP5Q RN Carbonic anhydrase inhibitors. Inhibition of the human cytosolic isozyme VII with aromatic and heterocyclic sulfonamides. Bioorg Med Chem Lett. 2005 Feb 15;15(4):971-6. DMROP5Q RU https://pubmed.ncbi.nlm.nih.gov/15686895 DMROP5Q DI DMROP5Q DMROP5Q DN Benzothiazole-2-sulfonic acid amide DMROP5Q MI TTHQPL7 DMROP5Q MN Carbonic anhydrase I (CA-I) DMROP5Q MT DTT DMROP5Q MA Inhibitor DMROP5Q RN Carbonic anhydrase inhibitors. Inhibition of the human cytosolic isozyme VII with aromatic and heterocyclic sulfonamides. Bioorg Med Chem Lett. 2005 Feb 15;15(4):971-6. DMROP5Q RU https://pubmed.ncbi.nlm.nih.gov/15686895 DMROP5Q DI DMROP5Q DMROP5Q DN Benzothiazole-2-sulfonic acid amide DMROP5Q MI TTANPDJ DMROP5Q MN Carbonic anhydrase II (CA-II) DMROP5Q MT DTT DMROP5Q MA Inhibitor DMROP5Q RN Carbonic anhydrase inhibitors. Inhibition of the human cytosolic isozyme VII with aromatic and heterocyclic sulfonamides. Bioorg Med Chem Lett. 2005 Feb 15;15(4):971-6. DMROP5Q RU https://pubmed.ncbi.nlm.nih.gov/15686895 DMC7TNF DI DMC7TNF DMC7TNF DN Benzoyl-Arginine-Alanine-Methyl Ketone DMC7TNF MI TTJOKD1 DMC7TNF MN Cathepsin F (CTSF) DMC7TNF MT DTT DMC7TNF MA Inhibitor DMC7TNF RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMC7TNF RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMC7TNF DI DMC7TNF DMC7TNF DN Benzoyl-Arginine-Alanine-Methyl Ketone DMC7TNF MI TTEAID7 DMC7TNF MN Trypanosoma Cruzipain (Trypano CYSP) DMC7TNF MT DTT DMC7TNF MA Inhibitor DMC7TNF RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMC7TNF RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMY5O1U DI DMY5O1U DMY5O1U DN BENZOYLENUREA DMY5O1U MI TT06AWU DMY5O1U MN Phosphodiesterase 3A (PDE3A) DMY5O1U MT DTT DMY5O1U MA Inhibitor DMY5O1U RN CODES, a novel procedure for ligand-based virtual screening: PDE7 inhibitors as an application example. Eur J Med Chem. 2008 Jul;43(7):1349-59. DMY5O1U RU https://pubmed.ncbi.nlm.nih.gov/18082290 DMIRD8S DI DMIRD8S DMIRD8S DN BENZOYL-TYROSINE-ALANINE-METHYL KETONE DMIRD8S MI TTJOKD1 DMIRD8S MN Cathepsin F (CTSF) DMIRD8S MT DTT DMIRD8S MA Inhibitor DMIRD8S RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DMIRD8S RU https://pubmed.ncbi.nlm.nih.gov/10592235 DMT3JYE DI DMT3JYE DMT3JYE DN Benzyl 2-hydroxyiminoolean-12-en-28-oate DMT3JYE MI TTZHY6R DMT3JYE MN Glycogen phosphorylase muscle form (GP) DMT3JYE MT DTT DMT3JYE MA Inhibitor DMT3JYE RN Synthesis of 3-deoxypentacyclic triterpene derivatives as inhibitors of glycogen phosphorylase. J Nat Prod. 2009 Aug;72(8):1414-8. DMT3JYE RU https://pubmed.ncbi.nlm.nih.gov/19642687 DMOKVAT DI DMOKVAT DMOKVAT DN Benzyl 4-aminobutyl(3-aminopropyl)carbamate DMOKVAT MI TTLD29N DMOKVAT MN Glutamate receptor ionotropic NMDA 1 (NMDAR1) DMOKVAT MT DTT DMOKVAT MA Inhibitor DMOKVAT RN Polyamines and the NMDA receptor: modifying intrinsic activities with aromatic substituents. Bioorg Med Chem Lett. 2006 Jun 1;16(11):2837-41. DMOKVAT RU https://pubmed.ncbi.nlm.nih.gov/16563762 DMOKVAT DI DMOKVAT DMOKVAT DN Benzyl 4-aminobutyl(3-aminopropyl)carbamate DMOKVAT MI TTKJEMQ DMOKVAT MN Glutamate receptor ionotropic NMDA 2A (NMDAR2A) DMOKVAT MT DTT DMOKVAT MA Inhibitor DMOKVAT RN Polyamines and the NMDA receptor: modifying intrinsic activities with aromatic substituents. Bioorg Med Chem Lett. 2006 Jun 1;16(11):2837-41. DMOKVAT RU https://pubmed.ncbi.nlm.nih.gov/16563762 DMOKVAT DI DMOKVAT DMOKVAT DN Benzyl 4-aminobutyl(3-aminopropyl)carbamate DMOKVAT MI TTN9D8E DMOKVAT MN Glutamate receptor ionotropic NMDA 2B (NMDAR2B) DMOKVAT MT DTT DMOKVAT MA Inhibitor DMOKVAT RN Polyamines and the NMDA receptor: modifying intrinsic activities with aromatic substituents. Bioorg Med Chem Lett. 2006 Jun 1;16(11):2837-41. DMOKVAT RU https://pubmed.ncbi.nlm.nih.gov/16563762 DM857X2 DI DM857X2 DM857X2 DN benzyl bromide DM857X2 MI TTELV3W DM857X2 MN Transformation-sensitive protein p120 (TRPA1) DM857X2 MT DTT DM857X2 MA Activator DM857X2 RN Transient receptor potential ankyrin 1 antagonists block the noxious effects of toxic industrial isocyanates and tear gases. FASEB J. 2009 Apr;23(4):1102-14. DM857X2 RU https://pubmed.ncbi.nlm.nih.gov/19036859 DMX8W4G DI DMX8W4G DMX8W4G DN Benzyl derivative of M6G DMX8W4G MI TT27RFC DMX8W4G MN Opioid receptor delta (OPRD1) DMX8W4G MT DTT DMX8W4G MA Inhibitor DMX8W4G RN Synthesis and in vitro biological evaluation of a carbon glycoside analogue of morphine-6-glucuronide. Bioorg Med Chem Lett. 2005 Mar 15;15(6):1583-6. DMX8W4G RU https://pubmed.ncbi.nlm.nih.gov/15745801 DMX8W4G DI DMX8W4G DMX8W4G DN Benzyl derivative of M6G DMX8W4G MI TTQW87Y DMX8W4G MN Opioid receptor kappa (OPRK1) DMX8W4G MT DTT DMX8W4G MA Inhibitor DMX8W4G RN Synthesis and in vitro biological evaluation of a carbon glycoside analogue of morphine-6-glucuronide. Bioorg Med Chem Lett. 2005 Mar 15;15(6):1583-6. DMX8W4G RU https://pubmed.ncbi.nlm.nih.gov/15745801 DMX8W4G DI DMX8W4G DMX8W4G DN Benzyl derivative of M6G DMX8W4G MI TTKWM86 DMX8W4G MN Opioid receptor mu (MOP) DMX8W4G MT DTT DMX8W4G MA Inhibitor DMX8W4G RN Synthesis and in vitro biological evaluation of a carbon glycoside analogue of morphine-6-glucuronide. Bioorg Med Chem Lett. 2005 Mar 15;15(6):1583-6. DMX8W4G RU https://pubmed.ncbi.nlm.nih.gov/15745801 DM6I5MU DI DM6I5MU DM6I5MU DN Benzyl-(2-imidazol-1-yl-quinazolin-4-yl)-amine DM6I5MU MI TTZ97H5 DM6I5MU MN Phosphodiesterase 4A (PDE4A) DM6I5MU MT DTT DM6I5MU MA Inhibitor DM6I5MU RN Discovery of potent cyclic GMP phosphodiesterase inhibitors. 2-Pyridyl- and 2-imidazolylquinazolines possessing cyclic GMP phosphodiesterase and th... J Med Chem. 1995 Sep 1;38(18):3547-57. DM6I5MU RU https://pubmed.ncbi.nlm.nih.gov/7658441 DM6I5MU DI DM6I5MU DM6I5MU DN Benzyl-(2-imidazol-1-yl-quinazolin-4-yl)-amine DM6I5MU MI TTVIAT9 DM6I5MU MN Phosphodiesterase 4B (PDE4B) DM6I5MU MT DTT DM6I5MU MA Inhibitor DM6I5MU RN Discovery of potent cyclic GMP phosphodiesterase inhibitors. 2-Pyridyl- and 2-imidazolylquinazolines possessing cyclic GMP phosphodiesterase and th... J Med Chem. 1995 Sep 1;38(18):3547-57. DM6I5MU RU https://pubmed.ncbi.nlm.nih.gov/7658441 DM3X50C DI DM3X50C DM3X50C DN Benzyl-(2-phenyl-quinazolin-4-yl)-amine DM3X50C MI TTVBI8W DM3X50C MN Dopamine transporter (DAT) DM3X50C MT DTT DM3X50C MA Inhibitor DM3X50C RN Identification of a novel partial inhibitor of dopamine transporter among 4-substituted 2-phenylquinazolines. Bioorg Med Chem Lett. 2002 Aug 19;12(16):2225-8. DM3X50C RU https://pubmed.ncbi.nlm.nih.gov/12127543 DM3X50C DI DM3X50C DM3X50C DN Benzyl-(2-phenyl-quinazolin-4-yl)-amine DM3X50C MI TTZ97H5 DM3X50C MN Phosphodiesterase 4A (PDE4A) DM3X50C MT DTT DM3X50C MA Inhibitor DM3X50C RN Discovery of potent cyclic GMP phosphodiesterase inhibitors. 2-Pyridyl- and 2-imidazolylquinazolines possessing cyclic GMP phosphodiesterase and th... J Med Chem. 1995 Sep 1;38(18):3547-57. DM3X50C RU https://pubmed.ncbi.nlm.nih.gov/7658441 DM3X50C DI DM3X50C DM3X50C DN Benzyl-(2-phenyl-quinazolin-4-yl)-amine DM3X50C MI TTVIAT9 DM3X50C MN Phosphodiesterase 4B (PDE4B) DM3X50C MT DTT DM3X50C MA Inhibitor DM3X50C RN Discovery of potent cyclic GMP phosphodiesterase inhibitors. 2-Pyridyl- and 2-imidazolylquinazolines possessing cyclic GMP phosphodiesterase and th... J Med Chem. 1995 Sep 1;38(18):3547-57. DM3X50C RU https://pubmed.ncbi.nlm.nih.gov/7658441 DMYDGCI DI DMYDGCI DMYDGCI DN Benzyl-(2-pyridin-3-yl-quinazolin-4-yl)-amine DMYDGCI MI TTJGW1Z DMYDGCI MN Phosphodiesterase 2A (PDE2A) DMYDGCI MT DTT DMYDGCI MA Inhibitor DMYDGCI RN Discovery of potent cyclic GMP phosphodiesterase inhibitors. 2-Pyridyl- and 2-imidazolylquinazolines possessing cyclic GMP phosphodiesterase and th... J Med Chem. 1995 Sep 1;38(18):3547-57. DMYDGCI RU https://pubmed.ncbi.nlm.nih.gov/7658441 DMYDGCI DI DMYDGCI DMYDGCI DN Benzyl-(2-pyridin-3-yl-quinazolin-4-yl)-amine DMYDGCI MI TTZ97H5 DMYDGCI MN Phosphodiesterase 4A (PDE4A) DMYDGCI MT DTT DMYDGCI MA Inhibitor DMYDGCI RN Discovery of potent cyclic GMP phosphodiesterase inhibitors. 2-Pyridyl- and 2-imidazolylquinazolines possessing cyclic GMP phosphodiesterase and th... J Med Chem. 1995 Sep 1;38(18):3547-57. DMYDGCI RU https://pubmed.ncbi.nlm.nih.gov/7658441 DMYDGCI DI DMYDGCI DMYDGCI DN Benzyl-(2-pyridin-3-yl-quinazolin-4-yl)-amine DMYDGCI MI TTVIAT9 DMYDGCI MN Phosphodiesterase 4B (PDE4B) DMYDGCI MT DTT DMYDGCI MA Inhibitor DMYDGCI RN Discovery of potent cyclic GMP phosphodiesterase inhibitors. 2-Pyridyl- and 2-imidazolylquinazolines possessing cyclic GMP phosphodiesterase and th... J Med Chem. 1995 Sep 1;38(18):3547-57. DMYDGCI RU https://pubmed.ncbi.nlm.nih.gov/7658441 DMESVWC DI DMESVWC DMESVWC DN Benzyl-(2-pyridin-4-yl-quinazolin-4-yl)-amine DMESVWC MI TTJGW1Z DMESVWC MN Phosphodiesterase 2A (PDE2A) DMESVWC MT DTT DMESVWC MA Inhibitor DMESVWC RN Discovery of potent cyclic GMP phosphodiesterase inhibitors. 2-Pyridyl- and 2-imidazolylquinazolines possessing cyclic GMP phosphodiesterase and th... J Med Chem. 1995 Sep 1;38(18):3547-57. DMESVWC RU https://pubmed.ncbi.nlm.nih.gov/7658441 DMESVWC DI DMESVWC DMESVWC DN Benzyl-(2-pyridin-4-yl-quinazolin-4-yl)-amine DMESVWC MI TTZ97H5 DMESVWC MN Phosphodiesterase 4A (PDE4A) DMESVWC MT DTT DMESVWC MA Inhibitor DMESVWC RN Discovery of potent cyclic GMP phosphodiesterase inhibitors. 2-Pyridyl- and 2-imidazolylquinazolines possessing cyclic GMP phosphodiesterase and th... J Med Chem. 1995 Sep 1;38(18):3547-57. DMESVWC RU https://pubmed.ncbi.nlm.nih.gov/7658441 DMESVWC DI DMESVWC DMESVWC DN Benzyl-(2-pyridin-4-yl-quinazolin-4-yl)-amine DMESVWC MI TTVIAT9 DMESVWC MN Phosphodiesterase 4B (PDE4B) DMESVWC MT DTT DMESVWC MA Inhibitor DMESVWC RN Discovery of potent cyclic GMP phosphodiesterase inhibitors. 2-Pyridyl- and 2-imidazolylquinazolines possessing cyclic GMP phosphodiesterase and th... J Med Chem. 1995 Sep 1;38(18):3547-57. DMESVWC RU https://pubmed.ncbi.nlm.nih.gov/7658441 DMH318X DI DMH318X DMH318X DN Benzyl-(2-thiophen-2-yl-quinazolin-4-yl)-amine DMH318X MI TTZ97H5 DMH318X MN Phosphodiesterase 4A (PDE4A) DMH318X MT DTT DMH318X MA Inhibitor DMH318X RN Discovery of potent cyclic GMP phosphodiesterase inhibitors. 2-Pyridyl- and 2-imidazolylquinazolines possessing cyclic GMP phosphodiesterase and th... J Med Chem. 1995 Sep 1;38(18):3547-57. DMH318X RU https://pubmed.ncbi.nlm.nih.gov/7658441 DMH318X DI DMH318X DMH318X DN Benzyl-(2-thiophen-2-yl-quinazolin-4-yl)-amine DMH318X MI TTVIAT9 DMH318X MN Phosphodiesterase 4B (PDE4B) DMH318X MT DTT DMH318X MA Inhibitor DMH318X RN Discovery of potent cyclic GMP phosphodiesterase inhibitors. 2-Pyridyl- and 2-imidazolylquinazolines possessing cyclic GMP phosphodiesterase and th... J Med Chem. 1995 Sep 1;38(18):3547-57. DMH318X RU https://pubmed.ncbi.nlm.nih.gov/7658441 DMFTIMS DI DMFTIMS DMFTIMS DN Benzyl-(6,7-dimethoxy-quinolin-3-yl)-amine DMFTIMS MI TT8FYO9 DMFTIMS MN Platelet-derived growth factor receptor alpha (PDGFRA) DMFTIMS MT DTT DMFTIMS MA Inhibitor DMFTIMS RN A new series of PDGF receptor tyrosine kinase inhibitors: 3-substituted quinoline derivatives. J Med Chem. 1994 Jul 8;37(14):2129-37. DMFTIMS RU https://pubmed.ncbi.nlm.nih.gov/8035419 DMFTIMS DI DMFTIMS DMFTIMS DN Benzyl-(6,7-dimethoxy-quinolin-3-yl)-amine DMFTIMS MI TTI7421 DMFTIMS MN Platelet-derived growth factor receptor beta (PDGFRB) DMFTIMS MT DTT DMFTIMS MA Inhibitor DMFTIMS RN A new series of PDGF receptor tyrosine kinase inhibitors: 3-substituted quinoline derivatives. J Med Chem. 1994 Jul 8;37(14):2129-37. DMFTIMS RU https://pubmed.ncbi.nlm.nih.gov/8035419 DMW167A DI DMW167A DMW167A DN Benzyl-(9H-beta-carbolin-6-yl)-amine DMW167A MI TT1MPAY DMW167A MN GABA(A) receptor alpha-1 (GABRA1) DMW167A MT DTT DMW167A MA Inhibitor DMW167A RN Synthesis of novel 3-substituted beta-carbolines as benzodiazepine receptor ligands: probing the benzodiazepine receptor pharmacophore. J Med Chem. 1988 Sep;31(9):1854-61. DMW167A RU https://pubmed.ncbi.nlm.nih.gov/2842507 DMW167A DI DMW167A DMW167A DN Benzyl-(9H-beta-carbolin-6-yl)-amine DMW167A MI TTNJYV2 DMW167A MN Gamma-aminobutyric acid receptor (GAR) DMW167A MT DTT DMW167A MA Inhibitor DMW167A RN Synthesis of novel 3-substituted beta-carbolines as benzodiazepine receptor ligands: probing the benzodiazepine receptor pharmacophore. J Med Chem. 1988 Sep;31(9):1854-61. DMW167A RU https://pubmed.ncbi.nlm.nih.gov/2842507 DMNE1M3 DI DMNE1M3 DMNE1M3 DN Benzyl-(9-isopropyl-9H-purin-6-yl)-amine DMNE1M3 MI TT7HF4W DMNE1M3 MN Cyclin-dependent kinase 2 (CDK2) DMNE1M3 MT DTT DMNE1M3 MA Inhibitor DMNE1M3 RN Docking-based development of purine-like inhibitors of cyclin-dependent kinase-2. J Med Chem. 2000 Jun 29;43(13):2506-13. DMNE1M3 RU https://pubmed.ncbi.nlm.nih.gov/10891109 DMTC4G0 DI DMTC4G0 DMTC4G0 DN Benzyl-[2-(1H-indazol-4-yloxy)-ethyl]-amine DMTC4G0 MI TTEX248 DMTC4G0 MN Dopamine D2 receptor (D2R) DMTC4G0 MT DTT DMTC4G0 MA Inhibitor DMTC4G0 RN New generation dopaminergic agents. 7. Heterocyclic bioisosteres that exploit the 3-OH-phenoxyethylamine D2 template. Bioorg Med Chem Lett. 1999 Sep 6;9(17):2593-8. DMTC4G0 RU https://pubmed.ncbi.nlm.nih.gov/10498215 DMTC4G0 DI DMTC4G0 DMTC4G0 DN Benzyl-[2-(1H-indazol-4-yloxy)-ethyl]-amine DMTC4G0 MI TT4C8EA DMTC4G0 MN Dopamine D3 receptor (D3R) DMTC4G0 MT DTT DMTC4G0 MA Inhibitor DMTC4G0 RN New generation dopaminergic agents. 7. Heterocyclic bioisosteres that exploit the 3-OH-phenoxyethylamine D2 template. Bioorg Med Chem Lett. 1999 Sep 6;9(17):2593-8. DMTC4G0 RU https://pubmed.ncbi.nlm.nih.gov/10498215 DMTC4G0 DI DMTC4G0 DMTC4G0 DN Benzyl-[2-(1H-indazol-4-yloxy)-ethyl]-amine DMTC4G0 MI TTE0A2F DMTC4G0 MN Dopamine D4 receptor (D4R) DMTC4G0 MT DTT DMTC4G0 MA Inhibitor DMTC4G0 RN New generation dopaminergic agents. 7. Heterocyclic bioisosteres that exploit the 3-OH-phenoxyethylamine D2 template. Bioorg Med Chem Lett. 1999 Sep 6;9(17):2593-8. DMTC4G0 RU https://pubmed.ncbi.nlm.nih.gov/10498215 DMV6DY7 DI DMV6DY7 DMV6DY7 DN Benzyl-[2-(1H-indol-4-yloxy)-ethyl]-amine DMV6DY7 MI TTEX248 DMV6DY7 MN Dopamine D2 receptor (D2R) DMV6DY7 MT DTT DMV6DY7 MA Inhibitor DMV6DY7 RN New generation dopaminergic agents. 7. Heterocyclic bioisosteres that exploit the 3-OH-phenoxyethylamine D2 template. Bioorg Med Chem Lett. 1999 Sep 6;9(17):2593-8. DMV6DY7 RU https://pubmed.ncbi.nlm.nih.gov/10498215 DMV6DY7 DI DMV6DY7 DMV6DY7 DN Benzyl-[2-(1H-indol-4-yloxy)-ethyl]-amine DMV6DY7 MI TT4C8EA DMV6DY7 MN Dopamine D3 receptor (D3R) DMV6DY7 MT DTT DMV6DY7 MA Inhibitor DMV6DY7 RN New generation dopaminergic agents. 7. Heterocyclic bioisosteres that exploit the 3-OH-phenoxyethylamine D2 template. Bioorg Med Chem Lett. 1999 Sep 6;9(17):2593-8. DMV6DY7 RU https://pubmed.ncbi.nlm.nih.gov/10498215 DMV6DY7 DI DMV6DY7 DMV6DY7 DN Benzyl-[2-(1H-indol-4-yloxy)-ethyl]-amine DMV6DY7 MI TTE0A2F DMV6DY7 MN Dopamine D4 receptor (D4R) DMV6DY7 MT DTT DMV6DY7 MA Inhibitor DMV6DY7 RN New generation dopaminergic agents. 7. Heterocyclic bioisosteres that exploit the 3-OH-phenoxyethylamine D2 template. Bioorg Med Chem Lett. 1999 Sep 6;9(17):2593-8. DMV6DY7 RU https://pubmed.ncbi.nlm.nih.gov/10498215 DMRM6ES DI DMRM6ES DMRM6ES DN Benzylamine DMRM6ES MI DE6SOC5 DMRM6ES MN Copper amine oxidase (AOC3) DMRM6ES MT DME DMRM6ES MA Metabolism DMRM6ES RN The unique substrate specificity of human AOC2, a semicarbazide-sensitive amine oxidase. Cell Mol Life Sci. 2009 Aug;66(16):2743-57. DMRM6ES RU https://www.ncbi.nlm.nih.gov/pubmed/?term=19588076 DMRM6ES DI DMRM6ES DMRM6ES DN Benzylamine DMRM6ES MI DERE4TU DMRM6ES MN Monoamine oxidase type A (MAO-A) DMRM6ES MT DME DMRM6ES MA Metabolism DMRM6ES RN Do monomeric vs dimeric forms of MAO-A make a difference? A direct comparison of the catalytic properties of rat and human MAO-A's. J Neural Transm (Vienna). 2007;114(6):721-4. DMRM6ES RU https://www.ncbi.nlm.nih.gov/pubmed/?term=17401534 DMRM6ES DI DMRM6ES DMRM6ES DN Benzylamine DMRM6ES MI DE8DP90 DMRM6ES MN Semicarbazide-sensitive amine oxidase (AOC2) DMRM6ES MT DME DMRM6ES MA Metabolism DMRM6ES RN The unique substrate specificity of human AOC2, a semicarbazide-sensitive amine oxidase. Cell Mol Life Sci. 2009 Aug;66(16):2743-57. DMRM6ES RU https://www.ncbi.nlm.nih.gov/pubmed/?term=19588076 DMFB4M5 DI DMFB4M5 DMFB4M5 DN Benzyl-biphenyl-4-ylmethyl-imidazol-1-yl-amine DMFB4M5 MI TTSZLWK DMFB4M5 MN Aromatase (CYP19A1) DMFB4M5 MT DTT DMFB4M5 MA Inhibitor DMFB4M5 RN CYP19 (aromatase): exploring the scaffold flexibility for novel selective inhibitors. Bioorg Med Chem. 2008 Sep 15;16(18):8349-58. DMFB4M5 RU https://pubmed.ncbi.nlm.nih.gov/18782670 DM7M9O2 DI DM7M9O2 DM7M9O2 DN Benzylcarbamic Acid Biphenyl-3-yl Ester DM7M9O2 MI TTDP1UC DM7M9O2 MN Fatty acid amide hydrolase (FAAH) DM7M9O2 MT DTT DM7M9O2 MA Inhibitor DM7M9O2 RN Synthesis and quantitative structure-activity relationship of fatty acid amide hydrolase inhibitors: modulation at the N-portion of biphenyl-3-yl a... J Med Chem. 2008 Jun 26;51(12):3487-98. DM7M9O2 RU https://pubmed.ncbi.nlm.nih.gov/18507372 DMTCYHM DI DMTCYHM DMTCYHM DN Benzylcysteine DMTCYHM MI TTJ8DV7 DMTCYHM MN O-6-methylguanine-DNA-alkyltransferase (MGMT) DMTCYHM MT DTT DMTCYHM MA Inhibitor DMTCYHM RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMTCYHM RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMNRHSO DI DMNRHSO DMNRHSO DN BENZYLIMIDAZOLE DMNRHSO MI TTIQUX7 DMNRHSO MN Steroid 11-beta-hydroxylase (CYP11B1) DMNRHSO MT DTT DMNRHSO MA Inhibitor DMNRHSO RN Synthesis, biological evaluation, and molecular modeling of 1-benzyl-1H-imidazoles as selective inhibitors of aldosterone synthase (CYP11B2). J Med Chem. 2010 Feb 25;53(4):1712-25. DMNRHSO RU https://pubmed.ncbi.nlm.nih.gov/20121113 DMQAEOL DI DMQAEOL DMQAEOL DN Benzyl-methyl-[1-(1H-pyrrol-2-yl)-vinyl]-amine DMQAEOL MI TTGP7BY DMQAEOL MN Monoamine oxidase type B (MAO-B) DMQAEOL MT DTT DMQAEOL MA Inhibitor DMQAEOL RN Simple, potent, and selective pyrrole inhibitors of monoamine oxidase types A and B. J Med Chem. 2003 Mar 13;46(6):917-20. DMQAEOL RU https://pubmed.ncbi.nlm.nih.gov/12620068 DMLJMOD DI DMLJMOD DMLJMOD DN Benzyloxycarbonyl-glycylryanodine DMLJMOD MI TTU5CIX DMLJMOD MN Ryanodine receptor 1 (RYR1) DMLJMOD MT DTT DMLJMOD MA Inhibitor DMLJMOD RN Amino- and guanidinoacylryanodines: basic ryanodine esters with enhanced affinity for the sarcoplasmic reticulum Ca(2+)-release channel. J Med Chem. 1993 May 14;36(10):1319-23. DMLJMOD RU https://pubmed.ncbi.nlm.nih.gov/8388466 DM26SR7 DI DM26SR7 DM26SR7 DN Benzyloxyresorufin DM26SR7 MI DE4OGUF DM26SR7 MN Cytochrome P450 102A1 (cyp102) DM26SR7 MT DME DM26SR7 MA Metabolism DM26SR7 RN The bacterial P450 BM3: a prototype for a biocatalyst with human P450 activities. Trends Biotechnol. 2007 Jul;25(7):289-98. DM26SR7 RU https://pubmed.ncbi.nlm.nih.gov/17532492 DM26SR7 DI DM26SR7 DM26SR7 DN Benzyloxyresorufin DM26SR7 MI DE4LYSA DM26SR7 MN Cytochrome P450 3A4 (CYP3A4) DM26SR7 MT DME DM26SR7 MA Metabolism DM26SR7 RN P450 enzyme expression patterns in the NCI human tumor cell line panel. Drug Metab Dispos. 2001 Mar;29(3):304-12. DM26SR7 RU https://pubmed.ncbi.nlm.nih.gov/11181500 DMRW5J4 DI DMRW5J4 DMRW5J4 DN Benzyl-quinazolin-4-yl-amine DMRW5J4 MI TTGKNB4 DMRW5J4 MN Epidermal growth factor receptor (EGFR) DMRW5J4 MT DTT DMRW5J4 MA Inhibitor DMRW5J4 RN Tyrosine kinase inhibitors. 5. Synthesis and structure-activity relationships for 4-[(phenylmethyl)amino]- and 4-(phenylamino)quinazolines as poten... J Med Chem. 1995 Sep 1;38(18):3482-7. DMRW5J4 RU https://pubmed.ncbi.nlm.nih.gov/7658435 DMHIGDM DI DMHIGDM DMHIGDM DN Benzylserine DMHIGDM MI TTF7WRM DMHIGDM MN Alanine/serine/cysteine transporter 2 (SLC1A5) DMHIGDM MT DTT DMHIGDM MA Inhibitor DMHIGDM RN New inhibitors for the neutral amino acid transporter ASCT2 reveal its Na+-dependent anion leak. J Physiol. 2004 Jun 15;557(Pt 3):747-59. DMHIGDM RU https://pubmed.ncbi.nlm.nih.gov/15107471 DM7XK28 DI DM7XK28 DM7XK28 DN Benzylsulfinic Acid DM7XK28 MI TT8VUE0 DM7XK28 MN Chymase (CYM) DM7XK28 MT DTT DM7XK28 MA Inhibitor DM7XK28 RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DM7XK28 RU https://pubmed.ncbi.nlm.nih.gov/10592235 DM7XK28 DI DM7XK28 DM7XK28 DN Benzylsulfinic Acid DM7XK28 MI TT25MVL DM7XK28 MN Serine protease hepsin (HPN) DM7XK28 MT DTT DM7XK28 MA Inhibitor DM7XK28 RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DM7XK28 RU https://pubmed.ncbi.nlm.nih.gov/10592235 DMDITNB DI DMDITNB DMDITNB DN BERGAPTOL DMDITNB MI TTXV4FI DMDITNB MN Albendazole monooxygenase (CYP3A4) DMDITNB MT DTT DMDITNB MA Inhibitor DMDITNB RN Radical scavenging and cytochrome P450 3A4 inhibitory activity of bergaptol and geranylcoumarin from grapefruit. Bioorg Med Chem. 2007 Jun 1;15(11):3684-91. DMDITNB RU https://pubmed.ncbi.nlm.nih.gov/17400460 DMP21ZO DI DMP21ZO DMP21ZO DN Beta-(2-Naphthyl)-Alanine DMP21ZO MI TT6L509 DMP21ZO MN Coagulation factor IIa (F2) DMP21ZO MT DTT DMP21ZO MA Inhibitor DMP21ZO RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DMP21ZO RU https://pubmed.ncbi.nlm.nih.gov/10592235 DMP21ZO DI DMP21ZO DMP21ZO DN Beta-(2-Naphthyl)-Alanine DMP21ZO MI TTJNTSI DMP21ZO MN Rotamase Pin1 (PIN1) DMP21ZO MT DTT DMP21ZO MA Inhibitor DMP21ZO RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DMP21ZO RU https://pubmed.ncbi.nlm.nih.gov/10592235 DM6FHQD DI DM6FHQD DM6FHQD DN Beta,beta-dimethylmelatonin DM6FHQD MI TT0WAIE DM6FHQD MN Melatonin receptor type 1A (MTNR1A) DM6FHQD MT DTT DM6FHQD MA Inhibitor DM6FHQD RN Mapping the melatonin receptor. 7. Subtype selective ligands based on beta-substituted N-acyl-5-methoxytryptamines and beta-substituted N-acyl-5-me... J Med Chem. 2006 Jun 15;49(12):3509-19. DM6FHQD RU https://pubmed.ncbi.nlm.nih.gov/16759094 DM6FHQD DI DM6FHQD DM6FHQD DN Beta,beta-dimethylmelatonin DM6FHQD MI TT32JK8 DM6FHQD MN Melatonin receptor type 1B (MTNR1B) DM6FHQD MT DTT DM6FHQD MA Inhibitor DM6FHQD RN Mapping the melatonin receptor. 7. Subtype selective ligands based on beta-substituted N-acyl-5-methoxytryptamines and beta-substituted N-acyl-5-me... J Med Chem. 2006 Jun 15;49(12):3509-19. DM6FHQD RU https://pubmed.ncbi.nlm.nih.gov/16759094 DM6GTBC DI DM6GTBC DM6GTBC DN Beta-1-C-butenyl-1-deoxygalactonojirimycin DM6GTBC MI TTIS03D DM6GTBC MN Alpha-galactosidase A (GLA) DM6GTBC MT DTT DM6GTBC MA Inhibitor DM6GTBC RN 2,5-Dideoxy-2,5-imino-d-altritol as a new class of pharmacological chaperone for Fabry disease. Bioorg Med Chem. 2010 Jun 1;18(11):3790-4. DM6GTBC RU https://pubmed.ncbi.nlm.nih.gov/20457528 DMMKDEZ DI DMMKDEZ DMMKDEZ DN Beta-1-C-Butyl-1-deoxygalactonojirimycin DMMKDEZ MI TTIS03D DMMKDEZ MN Alpha-galactosidase A (GLA) DMMKDEZ MT DTT DMMKDEZ MA Inhibitor DMMKDEZ RN 2,5-Dideoxy-2,5-imino-d-altritol as a new class of pharmacological chaperone for Fabry disease. Bioorg Med Chem. 2010 Jun 1;18(11):3790-4. DMMKDEZ RU https://pubmed.ncbi.nlm.nih.gov/20457528 DMBAN5P DI DMBAN5P DMBAN5P DN beta3-tetrapeptide DMBAN5P MI TTAE1BR DMBAN5P MN Somatostatin receptor type 4 (SSTR4) DMBAN5P MT DTT DMBAN5P MA Agonist DMBAN5P RN Beta(2)/beta(3)-di- and alpha/beta(3)-tetrapeptide derivatives as potent agonists at somatostatin sst(4) receptors. Naunyn Schmiedebergs Arch Pharmacol. 2003 Feb;367(2):95-103. DMBAN5P RU https://pubmed.ncbi.nlm.nih.gov/12595949 DMC64EI DI DMC64EI DMC64EI DN Beta-alanine DMC64EI MI TT8RXO5 DMC64EI MN GABA transporter-3 (SLC6A11) DMC64EI MT DTT DMC64EI MA Blocker DMC64EI RN Stable expression of a neuronal gamma-aminobutyric acid transporter, GAT-3, in mammalian cells demonstrates unique pharmacological properties and ion dependence. Mol Pharmacol. 1994 Sep;46(3):550-7. DMC64EI RU https://pubmed.ncbi.nlm.nih.gov/7935337 DMC64EI DI DMC64EI DMC64EI DN Beta-alanine DMC64EI MI DTX8KP0 DMC64EI MN Sodium- and chloride-dependent GABA transporter 2 (SLC6A13) DMC64EI MT DTP DMC64EI MA Substrate DMC64EI RN Astrocytic -aminobutyric acid (GABA) transporters mediate guanidinoacetate transport in rat brain. 2018 Feb;113:1-7. DMC64EI RU http://www.ncbi.nlm.nih.gov/pubmed/29175673 DMC64EI DI DMC64EI DMC64EI DN Beta-alanine DMC64EI MI DTXBIQG DMC64EI MN Sodium- and chloride-dependent GABA transporter 3 (SLC6A11) DMC64EI MT DTP DMC64EI MA Substrate DMC64EI RN Astrocytic -aminobutyric acid (GABA) transporters mediate guanidinoacetate transport in rat brain. 2018 Feb;113:1-7. DMC64EI RU http://www.ncbi.nlm.nih.gov/pubmed/29175673 DMC64EI DI DMC64EI DMC64EI DN Beta-alanine DMC64EI MI DTHWCVA DMC64EI MN Sodium- and chloride-dependent taurine transporter (SLC6A6) DMC64EI MT DTP DMC64EI MA Substrate DMC64EI RN Astrocytic -aminobutyric acid (GABA) transporters mediate guanidinoacetate transport in rat brain. 2018 Feb;113:1-7. DMC64EI RU http://www.ncbi.nlm.nih.gov/pubmed/29175673 DMN7DJ5 DI DMN7DJ5 DMN7DJ5 DN BetaARKct DMN7DJ5 MI TTAZ3MN DMN7DJ5 MN Beta-adrenergic receptor kinase 1 (ADRBK1) DMN7DJ5 MT DTT DMN7DJ5 MA Inhibitor DMN7DJ5 RN Gene-mediated inhibition of the b-adrenergic receptor kinase: a new therapeutic strategy for heart failure. Minerva Cardioangiol. 2001 Dec;49(6):389-94. DMN7DJ5 RU https://pubmed.ncbi.nlm.nih.gov/11733734 DM9LT60 DI DM9LT60 DM9LT60 DN Beta-Carboline-3-carboxylic acid t-butyl ester DM9LT60 MI TT1MPAY DM9LT60 MN GABA(A) receptor alpha-1 (GABRA1) DM9LT60 MT DTT DM9LT60 MA Inhibitor DM9LT60 RN Design, synthesis, and subtype selectivity of 3,6-disubstituted -carbolines at Bz/GABA(A)ergic receptors. SAR and studies directed toward agents f... Bioorg Med Chem. 2010 Nov 1;18(21):7548-64. DM9LT60 RU https://pubmed.ncbi.nlm.nih.gov/20888240 DM9LT60 DI DM9LT60 DM9LT60 DN Beta-Carboline-3-carboxylic acid t-butyl ester DM9LT60 MI TTBMV1G DM9LT60 MN GABA(A) receptor alpha-2 (GABRA2) DM9LT60 MT DTT DM9LT60 MA Inhibitor DM9LT60 RN Design, synthesis, and subtype selectivity of 3,6-disubstituted -carbolines at Bz/GABA(A)ergic receptors. SAR and studies directed toward agents f... Bioorg Med Chem. 2010 Nov 1;18(21):7548-64. DM9LT60 RU https://pubmed.ncbi.nlm.nih.gov/20888240 DM9LT60 DI DM9LT60 DM9LT60 DN Beta-Carboline-3-carboxylic acid t-butyl ester DM9LT60 MI TT37EDJ DM9LT60 MN GABA(A) receptor alpha-3 (GABRA3) DM9LT60 MT DTT DM9LT60 MA Inhibitor DM9LT60 RN Design, synthesis, and subtype selectivity of 3,6-disubstituted -carbolines at Bz/GABA(A)ergic receptors. SAR and studies directed toward agents f... Bioorg Med Chem. 2010 Nov 1;18(21):7548-64. DM9LT60 RU https://pubmed.ncbi.nlm.nih.gov/20888240 DM9LT60 DI DM9LT60 DM9LT60 DN Beta-Carboline-3-carboxylic acid t-butyl ester DM9LT60 MI TTNZPQ1 DM9LT60 MN GABA(A) receptor alpha-5 (GABRA5) DM9LT60 MT DTT DM9LT60 MA Inhibitor DM9LT60 RN Design, synthesis, and subtype selectivity of 3,6-disubstituted -carbolines at Bz/GABA(A)ergic receptors. SAR and studies directed toward agents f... Bioorg Med Chem. 2010 Nov 1;18(21):7548-64. DM9LT60 RU https://pubmed.ncbi.nlm.nih.gov/20888240 DM9LT60 DI DM9LT60 DM9LT60 DN Beta-Carboline-3-carboxylic acid t-butyl ester DM9LT60 MI TT06RH5 DM9LT60 MN GABA(A) receptor gamma-2 (GABRG2) DM9LT60 MT DTT DM9LT60 MA Inhibitor DM9LT60 RN Design, synthesis, and subtype selectivity of 3,6-disubstituted -carbolines at Bz/GABA(A)ergic receptors. SAR and studies directed toward agents f... Bioorg Med Chem. 2010 Nov 1;18(21):7548-64. DM9LT60 RU https://pubmed.ncbi.nlm.nih.gov/20888240 DM9LT60 DI DM9LT60 DM9LT60 DN Beta-Carboline-3-carboxylic acid t-butyl ester DM9LT60 MI TTNJYV2 DM9LT60 MN Gamma-aminobutyric acid receptor (GAR) DM9LT60 MT DTT DM9LT60 MA Inhibitor DM9LT60 RN Design, synthesis, and subtype selectivity of 3,6-disubstituted -carbolines at Bz/GABA(A)ergic receptors. SAR and studies directed toward agents f... Bioorg Med Chem. 2010 Nov 1;18(21):7548-64. DM9LT60 RU https://pubmed.ncbi.nlm.nih.gov/20888240 DM1MFTZ DI DM1MFTZ DM1MFTZ DN BETA-CCM DM1MFTZ MI TT1MPAY DM1MFTZ MN GABA(A) receptor alpha-1 (GABRA1) DM1MFTZ MT DTT DM1MFTZ MA Inhibitor DM1MFTZ RN Synthetic routes to 4-amino-3-carboxy-beta-carboline derivatives: incidental formation of novel furo[3,4-c]-beta-carbolin-2-ones displaying high af... J Med Chem. 1995 Jan 6;38(1):189-98. DM1MFTZ RU https://pubmed.ncbi.nlm.nih.gov/7837230 DM1MFTZ DI DM1MFTZ DM1MFTZ DN BETA-CCM DM1MFTZ MI TTZA1NY DM1MFTZ MN GABA(A) receptor beta-2 (GABRB2) DM1MFTZ MT DTT DM1MFTZ MA Inhibitor DM1MFTZ RN Four amino acid exchanges convert a diazepam-insensitive, inverse agonist-preferring GABAA receptor into a diazepam-preferring GABAA receptor. J Med Chem. 1994 Dec 23;37(26):4576-80. DM1MFTZ RU https://pubmed.ncbi.nlm.nih.gov/7799410 DM1MFTZ DI DM1MFTZ DM1MFTZ DN BETA-CCM DM1MFTZ MI TT06RH5 DM1MFTZ MN GABA(A) receptor gamma-2 (GABRG2) DM1MFTZ MT DTT DM1MFTZ MA Inhibitor DM1MFTZ RN beta-Carbolines as benzodiazepine receptor ligands. 1. Synthesis and benzodiazepine receptor interaction of esters of beta-carboline-3-carboxylic a... J Med Chem. 1983 Apr;26(4):499-503. DM1MFTZ RU https://pubmed.ncbi.nlm.nih.gov/6300400 DM1MFTZ DI DM1MFTZ DM1MFTZ DN BETA-CCM DM1MFTZ MI TTNJYV2 DM1MFTZ MN Gamma-aminobutyric acid receptor (GAR) DM1MFTZ MT DTT DM1MFTZ MA Inhibitor DM1MFTZ RN Synthetic routes to 4-amino-3-carboxy-beta-carboline derivatives: incidental formation of novel furo[3,4-c]-beta-carbolin-2-ones displaying high af... J Med Chem. 1995 Jan 6;38(1):189-98. DM1MFTZ RU https://pubmed.ncbi.nlm.nih.gov/7837230 DMZ2BR9 DI DMZ2BR9 DMZ2BR9 DN Beta-D-Glucopyranose Spirohydantoin DMZ2BR9 MI TTZHY6R DMZ2BR9 MN Glycogen phosphorylase muscle form (GP) DMZ2BR9 MT DTT DMZ2BR9 MA Inhibitor DMZ2BR9 RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMZ2BR9 RU https://pubmed.ncbi.nlm.nih.gov/17139284 DM5IHYP DI DM5IHYP DM5IHYP DN Beta-D-Glucose DM5IHYP MI TTHCF4J DM5IHYP MN Alpha-glucosidase (GLA) DM5IHYP MT DTT DM5IHYP MA Inhibitor DM5IHYP RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DM5IHYP RU https://pubmed.ncbi.nlm.nih.gov/17139284 DM5IHYP DI DM5IHYP DM5IHYP DN Beta-D-Glucose DM5IHYP MI TTVTX4N DM5IHYP MN Bacterial Fatty acid synthetase I (Bact inhA) DM5IHYP MT DTT DM5IHYP MA Inhibitor DM5IHYP RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DM5IHYP RU https://pubmed.ncbi.nlm.nih.gov/17139284 DM5IHYP DI DM5IHYP DM5IHYP DN Beta-D-Glucose DM5IHYP MI TTDLNGZ DM5IHYP MN Glucokinase (GCK) DM5IHYP MT DTT DM5IHYP MA Inhibitor DM5IHYP RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DM5IHYP RU https://pubmed.ncbi.nlm.nih.gov/17139284 DM5IHYP DI DM5IHYP DM5IHYP DN Beta-D-Glucose DM5IHYP MI TTZHY6R DM5IHYP MN Glycogen phosphorylase muscle form (GP) DM5IHYP MT DTT DM5IHYP MA Inhibitor DM5IHYP RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DM5IHYP RU https://pubmed.ncbi.nlm.nih.gov/17139284 DM5IHYP DI DM5IHYP DM5IHYP DN Beta-D-Glucose DM5IHYP MI TTUTN1I DM5IHYP MN Human Deoxyribonucleic acid (hDNA) DM5IHYP MT DTT DM5IHYP MA Inhibitor DM5IHYP RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DM5IHYP RU https://pubmed.ncbi.nlm.nih.gov/17139284 DM5IHYP DI DM5IHYP DM5IHYP DN Beta-D-Glucose DM5IHYP MI TTCGSZ4 DM5IHYP MN Pancreatic alpha-amylase (AMY2A) DM5IHYP MT DTT DM5IHYP MA Inhibitor DM5IHYP RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DM5IHYP RU https://pubmed.ncbi.nlm.nih.gov/17139284 DM5IHYP DI DM5IHYP DM5IHYP DN Beta-D-Glucose DM5IHYP MI TTNX2CS DM5IHYP MN Plasmodium Enoyl-ACP reductase (Malaria fabI) DM5IHYP MT DTT DM5IHYP MA Inhibitor DM5IHYP RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DM5IHYP RU https://pubmed.ncbi.nlm.nih.gov/17139284 DM5IHYP DI DM5IHYP DM5IHYP DN Beta-D-Glucose DM5IHYP MI TT8NGED DM5IHYP MN Prostaglandin G/H synthase 1 (COX-1) DM5IHYP MT DTT DM5IHYP MA Inhibitor DM5IHYP RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DM5IHYP RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMNE4C6 DI DMNE4C6 DMNE4C6 DN beta-D-hydroxybutyric acid DMNE4C6 MI TTWNV8U DMNE4C6 MN Nicotinic acid receptor (HCAR2) DMNE4C6 MT DTT DMNE4C6 MA Agonist DMNE4C6 RN (D)-beta-Hydroxybutyrate inhibits adipocyte lipolysis via the nicotinic acid receptor PUMA-G. J Biol Chem. 2005 Jul 22;280(29):26649-52. DMNE4C6 RU https://pubmed.ncbi.nlm.nih.gov/15929991 DMHIG9K DI DMHIG9K DMHIG9K DN Beta-D-Mannose DMHIG9K MI TTEYTKG DMHIG9K MN Carbonic anhydrase XIV (CA-XIV) DMHIG9K MT DTT DMHIG9K MA Inhibitor DMHIG9K RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMHIG9K RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMHIG9K DI DMHIG9K DMHIG9K DN Beta-D-Mannose DMHIG9K MI TTEB0GD DMHIG9K MN Cholinesterase (BCHE) DMHIG9K MT DTT DMHIG9K MA Inhibitor DMHIG9K RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMHIG9K RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMHIG9K DI DMHIG9K DMHIG9K DN Beta-D-Mannose DMHIG9K MI TT50QJ3 DMHIG9K MN Influenza Neuraminidase (Influ NA) DMHIG9K MT DTT DMHIG9K MA Inhibitor DMHIG9K RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMHIG9K RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMHIG9K DI DMHIG9K DMHIG9K DN Beta-D-Mannose DMHIG9K MI TT8NGED DMHIG9K MN Prostaglandin G/H synthase 1 (COX-1) DMHIG9K MT DTT DMHIG9K MA Inhibitor DMHIG9K RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMHIG9K RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMHIG9K DI DMHIG9K DMHIG9K DN Beta-D-Mannose DMHIG9K MI TTH0KSX DMHIG9K MN Rhodopsin (RHO) DMHIG9K MT DTT DMHIG9K MA Inhibitor DMHIG9K RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMHIG9K RU https://pubmed.ncbi.nlm.nih.gov/17139284 DM7XC6B DI DM7XC6B DM7XC6B DN Beta-endorphin DM7XC6B MI TT27RFC DM7XC6B MN Opioid receptor delta (OPRD1) DM7XC6B MT DTT DM7XC6B MA Agonist DM7XC6B RN Cross-linking of human [125I]beta-endorphin to opioid receptors in rat striatal membranes: biochemical evidence for the existence of a mu/delta opioid receptor complex. J Pharmacol Exp Ther. 1990 Apr;253(1):419-26. DM7XC6B RU https://pubmed.ncbi.nlm.nih.gov/2158552 DM7XC6B DI DM7XC6B DM7XC6B DN Beta-endorphin DM7XC6B MI TTQW87Y DM7XC6B MN Opioid receptor kappa (OPRK1) DM7XC6B MT DTT DM7XC6B MA Antagonist DM7XC6B RN Beta-endorphin is a potent inhibitor of thymidine incorporation into DNA via mu- and kappa-opioid receptors in fetal rat brain cell aggregates in culture. J Neurochem. 1993 Feb;60(2):765-7. DM7XC6B RU https://pubmed.ncbi.nlm.nih.gov/8380443 DM7XC6B DI DM7XC6B DM7XC6B DN Beta-endorphin DM7XC6B MI TTKWM86 DM7XC6B MN Opioid receptor mu (MOP) DM7XC6B MT DTT DM7XC6B MA Antagonist DM7XC6B RN Beta-endorphin is a potent inhibitor of thymidine incorporation into DNA via mu- and kappa-opioid receptors in fetal rat brain cell aggregates in culture. J Neurochem. 1993 Feb;60(2):765-7. DM7XC6B RU https://pubmed.ncbi.nlm.nih.gov/8380443 DMU3YXR DI DMU3YXR DMU3YXR DN beta-ergocriptine DMU3YXR MI TTS2PH3 DMU3YXR MN Dopamine D5 receptor (D5R) DMU3YXR MT DTT DMU3YXR MA Agonist DMU3YXR RN Cloning of the gene for a human dopamine D5 receptor with higher affinity for dopamine than D1. Nature. 1991 Apr 18;350(6319):614-9. DMU3YXR RU https://pubmed.ncbi.nlm.nih.gov/1826762 DM25QXM DI DM25QXM DM25QXM DN Beta-fructose phosphate DM25QXM MI DEEY674 DM25QXM MN PFK/FBPase 3 (PFKFB3) DM25QXM MT DME DM25QXM MA Metabolism DM25QXM RN The kinase activity of human brain 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase is regulated via inhibition by phosphoenolpyruvate. Arch Biochem Biophys. 2005 Jun 15;438(2):125-36. DM25QXM RU https://www.ncbi.nlm.nih.gov/pubmed/?term=15896703 DMJORFK DI DMJORFK DMJORFK DN Beta-funaltrexamine DMJORFK MI TTKWM86 DMJORFK MN Opioid receptor mu (MOP) DMJORFK MT DTT DMJORFK MA Inhibitor DMJORFK RN Discovery of dermorphin-based affinity labels with subnanomolar affinity for mu opioid receptors. J Med Chem. 2009 Dec 10;52(23):7372-5. DMJORFK RU https://pubmed.ncbi.nlm.nih.gov/19621878 DMO8LPZ DI DMO8LPZ DMO8LPZ DN Beta-Hydroxy Aspartic Acid DMO8LPZ MI TTCIHJA DMO8LPZ MN Coagulation factor Xa (F10) DMO8LPZ MT DTT DMO8LPZ MA Inhibitor DMO8LPZ RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DMO8LPZ RU https://pubmed.ncbi.nlm.nih.gov/10592235 DMGP9MN DI DMGP9MN DMGP9MN DN BETA-HYDROXYETHYL THEOPHYLLINE DMGP9MN MI TTNE7KG DMGP9MN MN Adenosine A2b receptor (ADORA2B) DMGP9MN MT DTT DMGP9MN MA Inhibitor DMGP9MN RN Insights into binding modes of adenosine A(2B) antagonists with ligand-based and receptor-based methods. Eur J Med Chem. 2010 Aug;45(8):3459-71. DMGP9MN RU https://pubmed.ncbi.nlm.nih.gov/20537438 DM6QV8A DI DM6QV8A DM6QV8A DN Beta-ionone DM6QV8A MI DEKYTSB DM6QV8A MN Cytochrome P450 101B1 (cyp101) DM6QV8A MT DME DM6QV8A MA Metabolism DM6QV8A RN nan DM6QV8A RU nan DM6QV8A DI DM6QV8A DM6QV8A DN Beta-ionone DM6QV8A MI DEGJFHV DM6QV8A MN Cytochrome P450 101C1 (cyp101) DM6QV8A MT DME DM6QV8A MA Metabolism DM6QV8A RN nan DM6QV8A RU nan DM6QV8A DI DM6QV8A DM6QV8A DN Beta-ionone DM6QV8A MI DE06B47 DM6QV8A MN Cytochrome P450 109B1 (cyp109) DM6QV8A MT DME DM6QV8A MA Metabolism DM6QV8A RN nan DM6QV8A RU nan DM3BOQA DI DM3BOQA DM3BOQA DN Beta-L-fucose DM3BOQA MI TT1RS9F DM3BOQA MN Acetylcholinesterase (AChE) DM3BOQA MT DTT DM3BOQA MA Inhibitor DM3BOQA RN DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Nucleic Acids Res. 2011 Jan;39(Database issue):D1035-41. DM3BOQA RU https://pubmed.ncbi.nlm.nih.gov/21059682 DMA9CSG DI DMA9CSG DMA9CSG DN Beta-methoxyamphetamine DMA9CSG MI TTNGILX DMA9CSG MN Adrenergic receptor alpha-1A (ADRA1A) DMA9CSG MT DTT DMA9CSG MA Agonist DMA9CSG RN Differential behavioural and neurochemical effects of para-methoxyamphetamine and 3,4-methylenedioxymethamphetamine in the rat. Prog Neuropsychopharmacol Biol Psychiatry. 2000 Aug;24(6):955-77. DMA9CSG RU https://pubmed.ncbi.nlm.nih.gov/11041537 DMA9CSG DI DMA9CSG DMA9CSG DN Beta-methoxyamphetamine DMA9CSG MI TT34BHT DMA9CSG MN Adrenergic receptor alpha-1D (ADRA1D) DMA9CSG MT DTT DMA9CSG MA Agonist DMA9CSG RN Differential behavioural and neurochemical effects of para-methoxyamphetamine and 3,4-methylenedioxymethamphetamine in the rat. Prog Neuropsychopharmacol Biol Psychiatry. 2000 Aug;24(6):955-77. DMA9CSG RU https://pubmed.ncbi.nlm.nih.gov/11041537 DMA9CSG DI DMA9CSG DMA9CSG DN Beta-methoxyamphetamine DMA9CSG MI TTWG9A4 DMA9CSG MN Adrenergic receptor alpha-2A (ADRA2A) DMA9CSG MT DTT DMA9CSG MA Agonist DMA9CSG RN Differential behavioural and neurochemical effects of para-methoxyamphetamine and 3,4-methylenedioxymethamphetamine in the rat. Prog Neuropsychopharmacol Biol Psychiatry. 2000 Aug;24(6):955-77. DMA9CSG RU https://pubmed.ncbi.nlm.nih.gov/11041537 DMA9CSG DI DMA9CSG DMA9CSG DN Beta-methoxyamphetamine DMA9CSG MI DECB0K3 DMA9CSG MN Cytochrome P450 2D6 (CYP2D6) DMA9CSG MT DME DMA9CSG MA Metabolism DMA9CSG RN Interactions of amphetamine analogs with human liver CYP2D6. Biochem Pharmacol. 1997 Jun 1;53(11):1605-12. DMA9CSG RU https://www.ncbi.nlm.nih.gov/pubmed/?term=9264312 DMA9CSG DI DMA9CSG DMA9CSG DN Beta-methoxyamphetamine DMA9CSG MI TTVBI8W DMA9CSG MN Dopamine transporter (DAT) DMA9CSG MT DTT DMA9CSG MA Antagonist DMA9CSG RN Differential behavioural and neurochemical effects of para-methoxyamphetamine and 3,4-methylenedioxymethamphetamine in the rat. Prog Neuropsychopharmacol Biol Psychiatry. 2000 Aug;24(6):955-77. DMA9CSG RU https://pubmed.ncbi.nlm.nih.gov/11041537 DMA9CSG DI DMA9CSG DMA9CSG DN Beta-methoxyamphetamine DMA9CSG MI TT3WG5C DMA9CSG MN Monoamine oxidase type A (MAO-A) DMA9CSG MT DTT DMA9CSG MA Inhibitor DMA9CSG RN Differential behavioural and neurochemical effects of para-methoxyamphetamine and 3,4-methylenedioxymethamphetamine in the rat. Prog Neuropsychopharmacol Biol Psychiatry. 2000 Aug;24(6):955-77. DMA9CSG RU https://pubmed.ncbi.nlm.nih.gov/11041537 DMA9CSG DI DMA9CSG DMA9CSG DN Beta-methoxyamphetamine DMA9CSG MI TTGP7BY DMA9CSG MN Monoamine oxidase type B (MAO-B) DMA9CSG MT DTT DMA9CSG MA Antagonist DMA9CSG RN Differential behavioural and neurochemical effects of para-methoxyamphetamine and 3,4-methylenedioxymethamphetamine in the rat. Prog Neuropsychopharmacol Biol Psychiatry. 2000 Aug;24(6):955-77. DMA9CSG RU https://pubmed.ncbi.nlm.nih.gov/11041537 DMA9CSG DI DMA9CSG DMA9CSG DN Beta-methoxyamphetamine DMA9CSG MI TT3ROYC DMA9CSG MN Serotonin transporter (SERT) DMA9CSG MT DTT DMA9CSG MA Inhibitor DMA9CSG RN Differential behavioural and neurochemical effects of para-methoxyamphetamine and 3,4-methylenedioxymethamphetamine in the rat. Prog Neuropsychopharmacol Biol Psychiatry. 2000 Aug;24(6):955-77. DMA9CSG RU https://pubmed.ncbi.nlm.nih.gov/11041537 DMA9CSG DI DMA9CSG DMA9CSG DN Beta-methoxyamphetamine DMA9CSG MI TTNZRI3 DMA9CSG MN Synaptic vesicle amine transporter (SLC18A2) DMA9CSG MT DTT DMA9CSG MA Antagonist DMA9CSG RN Differential behavioural and neurochemical effects of para-methoxyamphetamine and 3,4-methylenedioxymethamphetamine in the rat. Prog Neuropsychopharmacol Biol Psychiatry. 2000 Aug;24(6):955-77. DMA9CSG RU https://pubmed.ncbi.nlm.nih.gov/11041537 DMKH32S DI DMKH32S DMKH32S DN Beta-methylmelatonin DMKH32S MI TT0WAIE DMKH32S MN Melatonin receptor type 1A (MTNR1A) DMKH32S MT DTT DMKH32S MA Inhibitor DMKH32S RN Mapping the melatonin receptor. 7. Subtype selective ligands based on beta-substituted N-acyl-5-methoxytryptamines and beta-substituted N-acyl-5-me... J Med Chem. 2006 Jun 15;49(12):3509-19. DMKH32S RU https://pubmed.ncbi.nlm.nih.gov/16759094 DMKH32S DI DMKH32S DMKH32S DN Beta-methylmelatonin DMKH32S MI TT32JK8 DMKH32S MN Melatonin receptor type 1B (MTNR1B) DMKH32S MT DTT DMKH32S MA Inhibitor DMKH32S RN Mapping the melatonin receptor. 7. Subtype selective ligands based on beta-substituted N-acyl-5-methoxytryptamines and beta-substituted N-acyl-5-me... J Med Chem. 2006 Jun 15;49(12):3509-19. DMKH32S RU https://pubmed.ncbi.nlm.nih.gov/16759094 DMZ8Y67 DI DMZ8Y67 DMZ8Y67 DN Beta-naphthylboronic acid DMZ8Y67 MI TTUNARX DMZ8Y67 MN Carbonic anhydrase (CA) DMZ8Y67 MT DTT DMZ8Y67 MA Inhibitor DMZ8Y67 RN Carbonic anhydrase inhibitors. Inhibition of the fungal beta-carbonic anhydrases from Candida albicans and Cryptococcus neoformans with boronic acids. Bioorg Med Chem Lett. 2009 May 15;19(10):2642-5. DMZ8Y67 RU https://pubmed.ncbi.nlm.nih.gov/19375309 DMZ8Y67 DI DMZ8Y67 DMZ8Y67 DN Beta-naphthylboronic acid DMZ8Y67 MI TTHQPL7 DMZ8Y67 MN Carbonic anhydrase I (CA-I) DMZ8Y67 MT DTT DMZ8Y67 MA Inhibitor DMZ8Y67 RN Carbonic anhydrase inhibitors. Inhibition of the fungal beta-carbonic anhydrases from Candida albicans and Cryptococcus neoformans with boronic acids. Bioorg Med Chem Lett. 2009 May 15;19(10):2642-5. DMZ8Y67 RU https://pubmed.ncbi.nlm.nih.gov/19375309 DMZ8Y67 DI DMZ8Y67 DMZ8Y67 DN Beta-naphthylboronic acid DMZ8Y67 MI TTANPDJ DMZ8Y67 MN Carbonic anhydrase II (CA-II) DMZ8Y67 MT DTT DMZ8Y67 MA Inhibitor DMZ8Y67 RN Carbonic anhydrase inhibitors. Inhibition of the fungal beta-carbonic anhydrases from Candida albicans and Cryptococcus neoformans with boronic acids. Bioorg Med Chem Lett. 2009 May 15;19(10):2642-5. DMZ8Y67 RU https://pubmed.ncbi.nlm.nih.gov/19375309 DMQXMKB DI DMQXMKB DMQXMKB DN Beta-phenyl-D-phenylalanyl-N-propyl-L-prolinamide DMQXMKB MI TT6L509 DMQXMKB MN Coagulation factor IIa (F2) DMQXMKB MT DTT DMQXMKB MA Inhibitor DMQXMKB RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DMQXMKB RU https://pubmed.ncbi.nlm.nih.gov/10592235 DM4MZQW DI DM4MZQW DM4MZQW DN BETP DM4MZQW MI TTVIMDE DM4MZQW MN Glucagon-like peptide 1 receptor (GLP1R) DM4MZQW MT DTT DM4MZQW MA Modulator (allosteric modulator) DM4MZQW RN A potentiator of orthosteric ligand activity at GLP-1R acts via covalent modification. Nat Chem Biol. 2014 Aug;10(8):629-31. DM4MZQW RU https://pubmed.ncbi.nlm.nih.gov/24997604 DMGQRON DI DMGQRON DMGQRON DN BETULIN DMGQRON MI TTZHY6R DMGQRON MN Glycogen phosphorylase muscle form (GP) DMGQRON MT DTT DMGQRON MA Inhibitor DMGQRON RN Naturally occurring pentacyclic triterpenes as inhibitors of glycogen phosphorylase: synthesis, structure-activity relationships, and X-ray crystal... J Med Chem. 2008 Jun 26;51(12):3540-54. DMGQRON RU https://pubmed.ncbi.nlm.nih.gov/18517260 DMOQEZK DI DMOQEZK DMOQEZK DN BF/PC-18 DMOQEZK MI TTUMQVO DMOQEZK MN Cathepsin S (CTSS) DMOQEZK MT DTT DMOQEZK MA Inhibitor DMOQEZK RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2353). DMOQEZK RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2353 DMCWB1V DI DMCWB1V DMCWB1V DN BF/PC-21 DMCWB1V MI TTDZN01 DMCWB1V MN Cathepsin K (CTSK) DMCWB1V MT DTT DMCWB1V MA Inhibitor DMCWB1V RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2350). DMCWB1V RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2350 DM4XMZW DI DM4XMZW DM4XMZW DN BH4 DM4XMZW MI TTGSVH2 DM4XMZW MN Phenylalanine hydroxylase (PAH) DM4XMZW MT DTT DM4XMZW MA Modulator DM4XMZW RN Company report of BioMarin DM4XMZW RU http://www.biomarin.com/products/kuvan (Kuvan is the first and only FDA-approved medication for PKU to reduce blood Phe levels in patients with hyperphenylalaninemia (HPA) due to tetrahydrobiopterin (BH4-) responsive PKU.) DMP21ST DI DMP21ST DMP21ST DN BHF-177 DMP21ST MI TTDCVZW DMP21ST MN Gamma-aminobutyric acid B receptor (GABBR) DMP21ST MT DTT DMP21ST MA Modulator DMP21ST RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 241). DMP21ST RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=241 DMVH4LK DI DMVH4LK DMVH4LK DN Bhg-F-N-Y-Y-W DMVH4LK MI TTKRD0G DMVH4LK MN Endothelin A receptor (EDNRA) DMVH4LK MT DTT DMVH4LK MA Inhibitor DMVH4LK RN Res-701-1, synthesis and a reevaluation of its effects on the endothelin receptors, Bioorg. Med. Chem. Lett. 5(6):621-626 (1995). DMVH4LK RU http://www.sciencedirect.com/science/article/pii/0960894X95000847 DMVH4LK DI DMVH4LK DMVH4LK DN Bhg-F-N-Y-Y-W DMVH4LK MI TT3ZTGU DMVH4LK MN Endothelin B receptor (EDNRB) DMVH4LK MT DTT DMVH4LK MA Inhibitor DMVH4LK RN Res-701-1, synthesis and a reevaluation of its effects on the endothelin receptors, Bioorg. Med. Chem. Lett. 5(6):621-626 (1995). DMVH4LK RU http://www.sciencedirect.com/science/article/pii/0960894X95000847 DMZRS7A DI DMZRS7A DMZRS7A DN BHT-3034 DMZRS7A MI TTH18TF DMZRS7A MN Muscarinic acetylcholine receptor M5 (CHRM5) DMZRS7A MT DTT DMZRS7A MA Modulator DMZRS7A RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 467). DMZRS7A RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=467 DMI3ANC DI DMI3ANC DMI3ANC DN BI 7273 DMI3ANC MI TTR7L5Y DMI3ANC MN Bromodomain-containing protein 9 (BRD9) DMI3ANC MT DTT DMI3ANC MA Inhibitor DMI3ANC RN Structure-Based Design of an in Vivo Active Selective BRD9 Inhibitor. J Med Chem. 2016 May 26;59(10):4462-75. DMI3ANC RU https://pubmed.ncbi.nlm.nih.gov/26914985 DMN052T DI DMN052T DMN052T DN BI-32169 DMN052T MI TT9O6WS DMN052T MN Glucagon receptor (GCGR) DMN052T MT DTT DMN052T MA Inhibitor DMN052T RN BI-32169, a bicyclic 19-peptide with strong glucagon receptor antagonist activity from Streptomyces sp. J Nat Prod. 2004 Sep;67(9):1528-31. DMN052T RU https://pubmed.ncbi.nlm.nih.gov/15387654 DMRXK5G DI DMRXK5G DMRXK5G DN BI6015 DMRXK5G MI TT2F3CD DMRXK5G MN Hepatocyte nuclear factor 4-alpha (HNF4A) DMRXK5G MT DTT DMRXK5G MA Antagonist DMRXK5G RN HNF4alpha antagonists discovered by a high-throughput screen for modulators of the human insulin promoter. Chem Biol. 2012 Jul 27;19(7):806-18. DMRXK5G RU https://pubmed.ncbi.nlm.nih.gov/22840769 DM4RZ9A DI DM4RZ9A DM4RZ9A DN BIA DM4RZ9A MI TTKWFB8 DM4RZ9A MN Catechol-O-methyl-transferase (COMT) DM4RZ9A MT DTT DM4RZ9A MA Inhibitor DM4RZ9A RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DM4RZ9A RU https://pubmed.ncbi.nlm.nih.gov/10592235 DMUWO6D DI DMUWO6D DMUWO6D DN BIBF100 DMUWO6D MI TTGKIED DMUWO6D MN Fibroblast growth factor-2 (FGF2) DMUWO6D MT DTT DMUWO6D MA Inhibitor DMUWO6D RN Emerging therapies for multiple myeloma. Expert Opin Emerg Drugs. 2009 Mar;14(1):99-127. DMUWO6D RU https://pubmed.ncbi.nlm.nih.gov/19249983 DMUWO6D DI DMUWO6D DMUWO6D DN BIBF100 DMUWO6D MI TT9HKJA DMUWO6D MN Vascular endothelial growth factor (VEGF) DMUWO6D MT DTT DMUWO6D MA Inhibitor DMUWO6D RN Emerging therapies for multiple myeloma. Expert Opin Emerg Drugs. 2009 Mar;14(1):99-127. DMUWO6D RU https://pubmed.ncbi.nlm.nih.gov/19249983 DMDTLSP DI DMDTLSP DMDTLSP DN BIBF-1202 DMDTLSP MI TTUTJGQ DMDTLSP MN Vascular endothelial growth factor receptor 2 (KDR) DMDTLSP MT DTT DMDTLSP MA Inhibitor DMDTLSP RN Comprehensive analysis of kinase inhibitor selectivity. Nat Biotechnol. 2011 Oct 30;29(11):1046-51. DMDTLSP RU https://pubmed.ncbi.nlm.nih.gov/22037378 DML7HFP DI DML7HFP DML7HFP DN BIBO3304 DML7HFP MI TTRK9JT DML7HFP MN Neuropeptide Y receptor type 1 (NPY1R) DML7HFP MT DTT DML7HFP MA Antagonist DML7HFP RN Neuropeptide Y induced modulation of dopamine synthesis in the striatum. Regul Pept. 2005 Jul 15;129(1-3):73-8. DML7HFP RU https://pubmed.ncbi.nlm.nih.gov/15927700 DMFS2V9 DI DMFS2V9 DMFS2V9 DN BIC1 DMFS2V9 MI TTDP48B DMFS2V9 MN Bromodomain-containing protein 2 (BRD2) DMFS2V9 MT DTT DMFS2V9 MA Inhibitor DMFS2V9 RN Real-time imaging of histone H4K12-specific acetylation determines the modes of action of histone deacetylase and bromodomain inhibitors. Chem Biol. 2011 Apr 22;18(4):495-507. DMFS2V9 RU https://pubmed.ncbi.nlm.nih.gov/21513886 DMT5E36 DI DMT5E36 DMT5E36 DN Bicarbonate DMT5E36 MI DTF7GAL DMT5E36 MN Anion exchange protein 2 (SLC4A2) DMT5E36 MT DTP DMT5E36 MA Substrate DMT5E36 RN HCO3-/Cl- anion exchanger SLC4A2 is required for proper osteoclast differentiation and function. Proc Natl Acad Sci U S A. 2008 Nov 4;105(44):16934-9. DMT5E36 RU http://www.ncbi.nlm.nih.gov/pubmed/18971331 DMT5E36 DI DMT5E36 DMT5E36 DN Bicarbonate DMT5E36 MI DT4X2AH DMT5E36 MN Anion exchange protein 3 (SLC4A3) DMT5E36 MT DTP DMT5E36 MA Substrate DMT5E36 RN The SLC4 family of bicarbonate (HCO??) transporters. Mol Aspects Med. 2013 Apr-Jun;34(2-3):159-82. DMT5E36 RU http://www.ncbi.nlm.nih.gov/pubmed/23506864 DMT5E36 DI DMT5E36 DMT5E36 DN Bicarbonate DMT5E36 MI DTVGOLN DMT5E36 MN Anion exchange transporter (SLC26A6) DMT5E36 MT DTP DMT5E36 MA Substrate DMT5E36 RN Metabolon disruption: a mechanism that regulates bicarbonate transport. EMBO J. 2005 Jul 20;24(14):2499-511. DMT5E36 RU http://www.ncbi.nlm.nih.gov/pubmed/15990874 DMT5E36 DI DMT5E36 DMT5E36 DN Bicarbonate DMT5E36 MI DTOTME4 DMT5E36 MN Anion exchange transporter (SLC26A7) DMT5E36 MT DTP DMT5E36 MA Substrate DMT5E36 RN Vasopressin induces expression of the Cl-/HCO3- exchanger SLC26A7 in kidney medullary collecting ducts of Brattleboro rats. Am J Physiol Renal Physiol. 2006 May;290(5):F1194-201. DMT5E36 RU http://www.ncbi.nlm.nih.gov/pubmed/16352747 DMT5E36 DI DMT5E36 DMT5E36 DN Bicarbonate DMT5E36 MI DT0TZPS DMT5E36 MN Anion transporter/exchanger protein 9 (SLC26A9) DMT5E36 MT DTP DMT5E36 MA Substrate DMT5E36 RN SLC26A9 is expressed in gastric surface epithelial cells, mediates Cl-/HCO3- exchange, and is inhibited by NH4+. Am J Physiol Cell Physiol. 2005 Aug;289(2):C493-505. DMT5E36 RU http://www.ncbi.nlm.nih.gov/pubmed/15800055 DMT5E36 DI DMT5E36 DMT5E36 DN Bicarbonate DMT5E36 MI TT2LVK8 DMT5E36 MN Carbonic anhydrase IX (CA-IX) DMT5E36 MT DTT DMT5E36 MA Inhibitor DMT5E36 RN Carbonic anhydrase inhibitors. Inhibition of isozymes I, II, IV, V, and IX with anions isosteric and isoelectronic with sulfate, nitrate, and carbo... Bioorg Med Chem Lett. 2005 Feb 1;15(3):567-71. DMT5E36 RU https://pubmed.ncbi.nlm.nih.gov/15664814 DMT5E36 DI DMT5E36 DMT5E36 DN Bicarbonate DMT5E36 MI DTJ785O DMT5E36 MN Sulfate anion transporter 1 (SLC26A1) DMT5E36 MT DTP DMT5E36 MA Substrate DMT5E36 RN SLC26A Gene Family Participate in pH Regulation during Enamel Maturation. PLoS One. 2015 Dec 15;10(12):e0144703. DMT5E36 RU http://www.ncbi.nlm.nih.gov/pubmed/26671068 DMTRDPI DI DMTRDPI DMTRDPI DN Bicine DMTRDPI MI TTP86E2 DMTRDPI MN Plasminogen (PLG) DMTRDPI MT DTT DMTRDPI MA Inhibitor DMTRDPI RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMTRDPI RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMA6VQW DI DMA6VQW DMA6VQW DN Bicuculline DMA6VQW MI TTNJYV2 DMA6VQW MN Gamma-aminobutyric acid receptor (GAR) DMA6VQW MT DTT DMA6VQW MA Antagonist DMA6VQW RN GABA receptors inhibited by benzodiazepines mediate fast inhibitory transmission in the central amygdala. J Neurosci. 1999 Nov 15;19(22):9698-704. DMA6VQW RU https://pubmed.ncbi.nlm.nih.gov/10559379 DMA6VQW DI DMA6VQW DMA6VQW DN Bicuculline DMA6VQW MI TTAN6JD DMA6VQW MN Glutamate receptor AMPA (GRIA) DMA6VQW MT DTT DMA6VQW MA Antagonist DMA6VQW RN Effects of subcutaneous administration of the gamma-aminobutyric acid(A) receptor agonist muscimol on water intake in water-deprived rats. Physiol Behav. 2002 Nov;77(2-3):445-50. DMA6VQW RU https://pubmed.ncbi.nlm.nih.gov/12419421 DM4MUXT DI DM4MUXT DM4MUXT DN BIFENOX DM4MUXT MI TTLUQ8E DM4MUXT MN Hormone sensitive lipase (LIPE) DM4MUXT MT DTT DM4MUXT MA Inhibitor DM4MUXT RN Combining ligand-based pharmacophore modeling, quantitative structure-activity relationship analysis and in silico screening for the discovery of n... J Med Chem. 2008 Oct 23;51(20):6478-94. DM4MUXT RU https://pubmed.ncbi.nlm.nih.gov/18808096 DML4DQ3 DI DML4DQ3 DML4DQ3 DN BIIB-513 DML4DQ3 MI TTGSEFH DML4DQ3 MN Sodium/hydrogen exchanger 1 (SLC9A1) DML4DQ3 MT DTT DML4DQ3 MA Inhibitor DML4DQ3 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 948). DML4DQ3 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=948 DMR2SEB DI DMR2SEB DMR2SEB DN BIIE0246 DMR2SEB MI TTJ6WK9 DMR2SEB MN Neuropeptide Y receptor type 2 (NPY2R) DMR2SEB MT DTT DMR2SEB MA Antagonist DMR2SEB RN The peptide YY-preferring receptor mediating inhibition of small intestinal secretion is a peripheral Y(2) receptor: pharmacological evidence and molecular cloning. Mol Pharmacol. 2001 Jul;60(1):124-34. DMR2SEB RU https://pubmed.ncbi.nlm.nih.gov/11408607 DMU09E4 DI DMU09E4 DMU09E4 DN BIIL 260 DMU09E4 MI TTVJX54 DMU09E4 MN Leukotriene B4 receptor 2 (LTB4R2) DMU09E4 MT DTT DMU09E4 MA Antagonist DMU09E4 RN Clinical trial of a leucotriene B4 receptor antagonist, BIIL 284, in patients with rheumatoid arthritis. Ann Rheum Dis. 2007 May;66(5):628-32. DMU09E4 RU https://pubmed.ncbi.nlm.nih.gov/17170051 DMIY2HW DI DMIY2HW DMIY2HW DN Bile acid DMIY2HW MI TTSDVTR DMIY2HW MN G-protein coupled bile acid receptor 1 (GPBAR1) DMIY2HW MT DTT DMIY2HW MA Inhibitor DMIY2HW RN Synthesis and SAR of 2-aryl-3-aminomethylquinolines as agonists of the bile acid receptor TGR5. Bioorg Med Chem Lett. 2010 Oct 1;20(19):5718-21. DMIY2HW RU https://pubmed.ncbi.nlm.nih.gov/20801037 DMI0V4O DI DMI0V4O DMI0V4O DN Bilirubin DMI0V4O MI DTFI42L DMI0V4O MN Multidrug resistance-associated protein 2 (ABCC2) DMI0V4O MT DTP DMI0V4O MA Substrate DMI0V4O RN Transport of monoglucuronosyl and bisglucuronosyl bilirubin by recombinant human and rat multidrug resistance protein 2. Hepatology. 1999 Aug;30(2):485-90. DMI0V4O RU http://www.ncbi.nlm.nih.gov/pubmed/10421658 DMI0V4O DI DMI0V4O DMI0V4O DN Bilirubin DMI0V4O MI DT3D8F0 DMI0V4O MN Organic anion transporting polypeptide 1B1 (SLCO1B1) DMI0V4O MT DTP DMI0V4O MA Substrate DMI0V4O RN Role of organic anion-transporting polypeptides, OATP-A, OATP-C and OATP-8, in the human placenta-maternal liver tandem excretory pathway for foetal bilirubin. Biochem J. 2003 May 1;371(Pt 3):897-905. DMI0V4O RU http://www.ncbi.nlm.nih.gov/pubmed/12568656 DMI0V4O DI DMI0V4O DMI0V4O DN Bilirubin DMI0V4O MI DT9C1TS DMI0V4O MN Organic anion transporting polypeptide 1B3 (SLCO1B3) DMI0V4O MT DTP DMI0V4O MA Substrate DMI0V4O RN Role of organic anion-transporting polypeptides, OATP-A, OATP-C and OATP-8, in the human placenta-maternal liver tandem excretory pathway for foetal bilirubin. Biochem J. 2003 May 1;371(Pt 3):897-905. DMI0V4O RU http://www.ncbi.nlm.nih.gov/pubmed/12568656 DMI0V4O DI DMI0V4O DMI0V4O DN Bilirubin DMI0V4O MI DESD26P DMI0V4O MN UDP-glucuronosyltransferase 1A6 (UGT1A6) DMI0V4O MT DME DMI0V4O MA Metabolism DMI0V4O RN Structural and functional studies of UDP-glucuronosyltransferases. Drug Metab Rev. 1999 Nov;31(4):817-99. DMI0V4O RU https://www.ncbi.nlm.nih.gov/pubmed/?term=10575553 DMCA0WJ DI DMCA0WJ DMCA0WJ DN Biliverdine Ix Alpha DMCA0WJ MI TTI6V2A DMCA0WJ MN Heme oxygenase 1 (HMOX1) DMCA0WJ MT DTT DMCA0WJ MA Inhibitor DMCA0WJ RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMCA0WJ RU https://pubmed.ncbi.nlm.nih.gov/17139284 DM09Z35 DI DM09Z35 DM09Z35 DN bilobalide DM09Z35 MI TTPC4TU DM09Z35 MN 5-HT 3A receptor (HTR3A) DM09Z35 MT DTT DM09Z35 MA Blocker (channel blocker) DM09Z35 RN Binding sites for bilobalide, diltiazem, ginkgolide, and picrotoxinin at the 5-HT3 receptor. Mol Pharmacol. 2011 Jul;80(1):183-90. DM09Z35 RU https://pubmed.ncbi.nlm.nih.gov/21505038 DM09Z35 DI DM09Z35 DM09Z35 DN bilobalide DM09Z35 MI TTR6K75 DM09Z35 MN 5-HT 3B receptor (HTR3B) DM09Z35 MT DTT DM09Z35 MA Blocker (channel blocker) DM09Z35 RN Ginkgolide B and bilobalide block the pore of the 5-HT eceptor at a location that overlaps the picrotoxin binding site. Neuropharmacology. 2011 Feb-Mar;60(2-3):488-95. DM09Z35 RU https://pubmed.ncbi.nlm.nih.gov/21059362 DM09Z35 DI DM09Z35 DM09Z35 DN bilobalide DM09Z35 MI TTZ8EM9 DM09Z35 MN Glycine receptor (GlyR) DM09Z35 MT DTT DM09Z35 MA Antagonist DM09Z35 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 427). DM09Z35 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=427 DMPR14J DI DMPR14J DMPR14J DN Bimetopyrole DMPR14J MI TTVKILB DMPR14J MN Prostaglandin G/H synthase 2 (COX-2) DMPR14J MT DTT DMPR14J MA Inhibitor DMPR14J RN Current status of COX-2 inhibitors. Mini Rev Med Chem. 2008 Jan;8(1):73-90. DMPR14J RU https://pubmed.ncbi.nlm.nih.gov/18220987 DM0HPWY DI DM0HPWY DM0HPWY DN biochanin A DM0HPWY MI TTSZLWK DM0HPWY MN Aromatase (CYP19A1) DM0HPWY MT DTT DM0HPWY MA Inhibitor DM0HPWY RN Pharmacophore modeling strategies for the development of novel nonsteroidal inhibitors of human aromatase (CYP19). Bioorg Med Chem Lett. 2010 May 15;20(10):3050-64. DM0HPWY RU https://pubmed.ncbi.nlm.nih.gov/20413308 DM0HPWY DI DM0HPWY DM0HPWY DN biochanin A DM0HPWY MI TTPNQAC DM0HPWY MN Estrogen-related receptor-alpha (ESRRA) DM0HPWY MT DTT DM0HPWY MA Agonist DM0HPWY RN Flavone and isoflavone phytoestrogens are agonists of estrogen-related receptors. Mol Cancer Res. 2003 Nov;1(13):981-91. DM0HPWY RU https://pubmed.ncbi.nlm.nih.gov/14638870 DM0HPWY DI DM0HPWY DM0HPWY DN biochanin A DM0HPWY MI TTKF0XS DM0HPWY MN Estrogen-related receptor-beta (ESRRB) DM0HPWY MT DTT DM0HPWY MA Agonist DM0HPWY RN Flavone and isoflavone phytoestrogens are agonists of estrogen-related receptors. Mol Cancer Res. 2003 Nov;1(13):981-91. DM0HPWY RU https://pubmed.ncbi.nlm.nih.gov/14638870 DM0HPWY DI DM0HPWY DM0HPWY DN biochanin A DM0HPWY MI TT9ZRHB DM0HPWY MN Estrogen-related receptor-gamma (ESRRG) DM0HPWY MT DTT DM0HPWY MA Agonist DM0HPWY RN Flavone and isoflavone phytoestrogens are agonists of estrogen-related receptors. Mol Cancer Res. 2003 Nov;1(13):981-91. DM0HPWY RU https://pubmed.ncbi.nlm.nih.gov/14638870 DM0HPWY DI DM0HPWY DM0HPWY DN biochanin A DM0HPWY MI TT7AOUD DM0HPWY MN Fatty acid synthase (FASN) DM0HPWY MT DTT DM0HPWY MA Inhibitor DM0HPWY RN Inhibition of Plasmodium falciparum fatty acid biosynthesis: evaluation of FabG, FabZ, and FabI as drug targets for flavonoids. J Med Chem. 2006 Jun 1;49(11):3345-53. DM0HPWY RU https://pubmed.ncbi.nlm.nih.gov/16722653 DM0HPWY DI DM0HPWY DM0HPWY DN biochanin A DM0HPWY MI TTHPFTS DM0HPWY MN Plasmodium Beta-hydroxyacyl-ACP dehydratase (Malaria FabZ) DM0HPWY MT DTT DM0HPWY MA Inhibitor DM0HPWY RN Inhibition of Plasmodium falciparum fatty acid biosynthesis: evaluation of FabG, FabZ, and FabI as drug targets for flavonoids. J Med Chem. 2006 Jun 1;49(11):3345-53. DM0HPWY RU https://pubmed.ncbi.nlm.nih.gov/16722653 DMLNQ2F DI DMLNQ2F DMLNQ2F DN Biopterin DMLNQ2F MI TT9SL3Q DMLNQ2F MN Polypeptide deformylase (PDF) DMLNQ2F MT DTT DMLNQ2F MA Inhibitor DMLNQ2F RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMLNQ2F RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMKMCE1 DI DMKMCE1 DMKMCE1 DN Biotin DMKMCE1 MI DT342ZG DMKMCE1 MN Monocarboxylate transporter 1 (SLC16A1) DMKMCE1 MT DTP DMKMCE1 MA Substrate DMKMCE1 RN Biotin. Biofactors. 2009 Jan-Feb;35(1):36-46. DMKMCE1 RU http://www.ncbi.nlm.nih.gov/pubmed/19319844 DMKMCE1 DI DMKMCE1 DMKMCE1 DN Biotin DMKMCE1 MI DTUGYRD DMKMCE1 MN P-glycoprotein 1 (ABCB1) DMKMCE1 MT DTP DMKMCE1 MA Substrate DMKMCE1 RN Functional characterization of sodium-dependent multivitamin transporter in MDCK-MDR1 cells and its utilization as a target for drug delivery. Mol Pharm. 2006 May-Jun;3(3):329-39. DMKMCE1 RU http://www.ncbi.nlm.nih.gov/pubmed/16749865 DMVOJ0X DI DMVOJ0X DMVOJ0X DN BioVant DMVOJ0X MI TT3J5ZI DMVOJ0X MN Cell mediated immunity response (CMIR) DMVOJ0X MT DTT DMVOJ0X RN Calcium Phosphate Nanoparticle Adjuvant. Clin Diagn Lab Immunol. 2000 November; 7(6): 899-903. DMVOJ0X RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC95982/ DM4D7V6 DI DM4D7V6 DM4D7V6 DN Biphenyl-2-ylmethyl-(S)-pyrrolidin-3-yl-amine DM4D7V6 MI TTVBI8W DM4D7V6 MN Dopamine transporter (DAT) DM4D7V6 MT DTT DM4D7V6 MA Inhibitor DM4D7V6 RN Derivatives of (3S)-N-(biphenyl-2-ylmethyl)pyrrolidin-3-amine as selective noradrenaline reuptake inhibitors: Reducing P-gp mediated efflux by modu... Bioorg Med Chem Lett. 2008 Aug 1;18(15):4355-9. DM4D7V6 RU https://pubmed.ncbi.nlm.nih.gov/18621528 DM4D7V6 DI DM4D7V6 DM4D7V6 DN Biphenyl-2-ylmethyl-(S)-pyrrolidin-3-yl-amine DM4D7V6 MI TTAWNKZ DM4D7V6 MN Norepinephrine transporter (NET) DM4D7V6 MT DTT DM4D7V6 MA Inhibitor DM4D7V6 RN Derivatives of (3S)-N-(biphenyl-2-ylmethyl)pyrrolidin-3-amine as selective noradrenaline reuptake inhibitors: Reducing P-gp mediated efflux by modu... Bioorg Med Chem Lett. 2008 Aug 1;18(15):4355-9. DM4D7V6 RU https://pubmed.ncbi.nlm.nih.gov/18621528 DM4D7V6 DI DM4D7V6 DM4D7V6 DN Biphenyl-2-ylmethyl-(S)-pyrrolidin-3-yl-amine DM4D7V6 MI TT3ROYC DM4D7V6 MN Serotonin transporter (SERT) DM4D7V6 MT DTT DM4D7V6 MA Inhibitor DM4D7V6 RN Derivatives of (3S)-N-(biphenyl-2-ylmethyl)pyrrolidin-3-amine as selective noradrenaline reuptake inhibitors: Reducing P-gp mediated efflux by modu... Bioorg Med Chem Lett. 2008 Aug 1;18(15):4355-9. DM4D7V6 RU https://pubmed.ncbi.nlm.nih.gov/18621528 DMROG71 DI DMROG71 DMROG71 DN Biphenyl-3-carboxylic acid hydroxyamide DMROG71 MI TT2J34L DMROG71 MN Arachidonate 5-lipoxygenase (5-LOX) DMROG71 MT DTT DMROG71 MA Inhibitor DMROG71 RN Hydroxamic acid inhibitors of 5-lipoxygenase: quantitative structure-activity relationships. J Med Chem. 1990 Mar;33(3):992-8. DMROG71 RU https://pubmed.ncbi.nlm.nih.gov/2308149 DMIAUB1 DI DMIAUB1 DMIAUB1 DN Biphenyl-3-ylboronic acid DMIAUB1 MI TTDP1UC DMIAUB1 MN Fatty acid amide hydrolase (FAAH) DMIAUB1 MT DTT DMIAUB1 MA Inhibitor DMIAUB1 RN Discovery of boronic acids as novel and potent inhibitors of fatty acid amide hydrolase. J Med Chem. 2008 Nov 27;51(22):7057-60. DMIAUB1 RU https://pubmed.ncbi.nlm.nih.gov/18983140 DMYCKGH DI DMYCKGH DMYCKGH DN Biphenyl-3-ylcarbamic Acid Biphenyl-3-yl Ester DMYCKGH MI TTDP1UC DMYCKGH MN Fatty acid amide hydrolase (FAAH) DMYCKGH MT DTT DMYCKGH MA Inhibitor DMYCKGH RN Synthesis and quantitative structure-activity relationship of fatty acid amide hydrolase inhibitors: modulation at the N-portion of biphenyl-3-yl a... J Med Chem. 2008 Jun 26;51(12):3487-98. DMYCKGH RU https://pubmed.ncbi.nlm.nih.gov/18507372 DM10AUP DI DM10AUP DM10AUP DN Biphenyl-3-ylcarbamic acid cyclohexyl ester DM10AUP MI TTDP1UC DM10AUP MN Fatty acid amide hydrolase (FAAH) DM10AUP MT DTT DM10AUP MA Inhibitor DM10AUP RN Synthesis and in vitro evaluation of N-substituted maleimide derivatives as selective monoglyceride lipase inhibitors. J Med Chem. 2009 Dec 10;52(23):7410-20. DM10AUP RU https://pubmed.ncbi.nlm.nih.gov/19583260 DMK5VYG DI DMK5VYG DMK5VYG DN Biphenyl-4-carboxylic acid hydroxyamide DMK5VYG MI TT2J34L DMK5VYG MN Arachidonate 5-lipoxygenase (5-LOX) DMK5VYG MT DTT DMK5VYG MA Inhibitor DMK5VYG RN Hydroxamic acid inhibitors of 5-lipoxygenase: quantitative structure-activity relationships. J Med Chem. 1990 Mar;33(3):992-8. DMK5VYG RU https://pubmed.ncbi.nlm.nih.gov/2308149 DM5DPHO DI DM5DPHO DM5DPHO DN BIPHENYL-4-YL-ACETALDEHYDE DM5DPHO MI TT36ETB DM5DPHO MN Cathepsin L (CTSL) DM5DPHO MT DTT DM5DPHO MA Inhibitor DM5DPHO RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DM5DPHO RU https://pubmed.ncbi.nlm.nih.gov/10592235 DMIHMP5 DI DMIHMP5 DMIHMP5 DN Biphenyl-4-ylboronic acid DMIHMP5 MI TTUNARX DMIHMP5 MN Carbonic anhydrase (CA) DMIHMP5 MT DTT DMIHMP5 MA Inhibitor DMIHMP5 RN Carbonic anhydrase inhibitors. Inhibition of the fungal beta-carbonic anhydrases from Candida albicans and Cryptococcus neoformans with boronic acids. Bioorg Med Chem Lett. 2009 May 15;19(10):2642-5. DMIHMP5 RU https://pubmed.ncbi.nlm.nih.gov/19375309 DMIHMP5 DI DMIHMP5 DMIHMP5 DN Biphenyl-4-ylboronic acid DMIHMP5 MI TTHQPL7 DMIHMP5 MN Carbonic anhydrase I (CA-I) DMIHMP5 MT DTT DMIHMP5 MA Inhibitor DMIHMP5 RN Carbonic anhydrase inhibitors. Inhibition of the fungal beta-carbonic anhydrases from Candida albicans and Cryptococcus neoformans with boronic acids. Bioorg Med Chem Lett. 2009 May 15;19(10):2642-5. DMIHMP5 RU https://pubmed.ncbi.nlm.nih.gov/19375309 DMIHMP5 DI DMIHMP5 DMIHMP5 DN Biphenyl-4-ylboronic acid DMIHMP5 MI TTANPDJ DMIHMP5 MN Carbonic anhydrase II (CA-II) DMIHMP5 MT DTT DMIHMP5 MA Inhibitor DMIHMP5 RN Carbonic anhydrase inhibitors. Inhibition of the fungal beta-carbonic anhydrases from Candida albicans and Cryptococcus neoformans with boronic acids. Bioorg Med Chem Lett. 2009 May 15;19(10):2642-5. DMIHMP5 RU https://pubmed.ncbi.nlm.nih.gov/19375309 DMIHMP5 DI DMIHMP5 DMIHMP5 DN Biphenyl-4-ylboronic acid DMIHMP5 MI TTDP1UC DMIHMP5 MN Fatty acid amide hydrolase (FAAH) DMIHMP5 MT DTT DMIHMP5 MA Inhibitor DMIHMP5 RN Discovery of boronic acids as novel and potent inhibitors of fatty acid amide hydrolase. J Med Chem. 2008 Nov 27;51(22):7057-60. DMIHMP5 RU https://pubmed.ncbi.nlm.nih.gov/18983140 DM2MYKC DI DM2MYKC DM2MYKC DN biphenylindanone A DM2MYKC MI TTXJ47W DM2MYKC MN Metabotropic glutamate receptor 2 (mGluR2) DM2MYKC MT DTT DM2MYKC MA Modulator (allosteric modulator) DM2MYKC RN Biphenyl-indanones: allosteric potentiators of the metabotropic glutamate subtype 2 receptor. Bioorg Med Chem Lett. 2005 Oct 1;15(19):4354-8. DM2MYKC RU https://pubmed.ncbi.nlm.nih.gov/16046122 DM4FSXK DI DM4FSXK DM4FSXK DN Bip-tyr(3bzl)-thr-pro-lys-thr DM4FSXK MI TTVBI8W DM4FSXK MN Dopamine transporter (DAT) DM4FSXK MT DTT DM4FSXK MA Inhibitor DM4FSXK RN Development of peptidic dopamine transporter inhibitors via aromatic modification-mediated conformational restriction. J Med Chem. 2006 Jul 13;49(14):4048-51. DM4FSXK RU https://pubmed.ncbi.nlm.nih.gov/16821765 DM0VKA2 DI DM0VKA2 DM0VKA2 DN Bip-tyr-ala-pro-lys-thr(obzl)-gly DM0VKA2 MI TTVBI8W DM0VKA2 MN Dopamine transporter (DAT) DM0VKA2 MT DTT DM0VKA2 MA Inhibitor DM0VKA2 RN Development of peptidic dopamine transporter inhibitors via aromatic modification-mediated conformational restriction. J Med Chem. 2006 Jul 13;49(14):4048-51. DM0VKA2 RU https://pubmed.ncbi.nlm.nih.gov/16821765 DMUWE81 DI DMUWE81 DMUWE81 DN Bip-tyr-thr-ala-pro-phe DMUWE81 MI TTVBI8W DMUWE81 MN Dopamine transporter (DAT) DMUWE81 MT DTT DMUWE81 MA Inhibitor DMUWE81 RN Development of peptidic dopamine transporter inhibitors via aromatic modification-mediated conformational restriction. J Med Chem. 2006 Jul 13;49(14):4048-51. DMUWE81 RU https://pubmed.ncbi.nlm.nih.gov/16821765 DMN38JC DI DMN38JC DMN38JC DN Bip-tyr-thr-pro-ala-thr(obzl)-gly DMN38JC MI TTVBI8W DMN38JC MN Dopamine transporter (DAT) DMN38JC MT DTT DMN38JC MA Inhibitor DMN38JC RN Development of peptidic dopamine transporter inhibitors via aromatic modification-mediated conformational restriction. J Med Chem. 2006 Jul 13;49(14):4048-51. DMN38JC RU https://pubmed.ncbi.nlm.nih.gov/16821765 DM7EKH3 DI DM7EKH3 DM7EKH3 DN Bip-tyr-thr-pro-lys-thr DM7EKH3 MI TTVBI8W DM7EKH3 MN Dopamine transporter (DAT) DM7EKH3 MT DTT DM7EKH3 MA Inhibitor DM7EKH3 RN Development of peptidic dopamine transporter inhibitors via aromatic modification-mediated conformational restriction. J Med Chem. 2006 Jul 13;49(14):4048-51. DM7EKH3 RU https://pubmed.ncbi.nlm.nih.gov/16821765 DMAPX9G DI DMAPX9G DMAPX9G DN Bip-tyr-thr-pro-lys-thr(obzl)-gly DMAPX9G MI TTVBI8W DMAPX9G MN Dopamine transporter (DAT) DMAPX9G MT DTT DMAPX9G MA Inhibitor DMAPX9G RN Development of peptidic dopamine transporter inhibitors via aromatic modification-mediated conformational restriction. J Med Chem. 2006 Jul 13;49(14):4048-51. DMAPX9G RU https://pubmed.ncbi.nlm.nih.gov/16821765 DM4CZ5B DI DM4CZ5B DM4CZ5B DN Bip-tyr-thr-pro-thr(obzl)-gly DM4CZ5B MI TTVBI8W DM4CZ5B MN Dopamine transporter (DAT) DM4CZ5B MT DTT DM4CZ5B MA Inhibitor DM4CZ5B RN Development of peptidic dopamine transporter inhibitors via aromatic modification-mediated conformational restriction. J Med Chem. 2006 Jul 13;49(14):4048-51. DM4CZ5B RU https://pubmed.ncbi.nlm.nih.gov/16821765 DM0WKNI DI DM0WKNI DM0WKNI DN Bis-((-)-N-propargylmorphinan-3-yl) sebacoylate DM0WKNI MI TT27RFC DM0WKNI MN Opioid receptor delta (OPRD1) DM0WKNI MT DTT DM0WKNI MA Inhibitor DM0WKNI RN Synthesis and preliminary in vitro investigation of bivalent ligands containing homo- and heterodimeric pharmacophores at mu, delta, and kappa opio... J Med Chem. 2006 Jan 12;49(1):256-62. DM0WKNI RU https://pubmed.ncbi.nlm.nih.gov/16392810 DM0WKNI DI DM0WKNI DM0WKNI DN Bis-((-)-N-propargylmorphinan-3-yl) sebacoylate DM0WKNI MI TTQW87Y DM0WKNI MN Opioid receptor kappa (OPRK1) DM0WKNI MT DTT DM0WKNI MA Inhibitor DM0WKNI RN Synthesis and preliminary in vitro investigation of bivalent ligands containing homo- and heterodimeric pharmacophores at mu, delta, and kappa opio... J Med Chem. 2006 Jan 12;49(1):256-62. DM0WKNI RU https://pubmed.ncbi.nlm.nih.gov/16392810 DM0WKNI DI DM0WKNI DM0WKNI DN Bis-((-)-N-propargylmorphinan-3-yl) sebacoylate DM0WKNI MI TTKWM86 DM0WKNI MN Opioid receptor mu (MOP) DM0WKNI MT DTT DM0WKNI MA Inhibitor DM0WKNI RN Synthesis and preliminary in vitro investigation of bivalent ligands containing homo- and heterodimeric pharmacophores at mu, delta, and kappa opio... J Med Chem. 2006 Jan 12;49(1):256-62. DM0WKNI RU https://pubmed.ncbi.nlm.nih.gov/16392810 DMWAS4Q DI DMWAS4Q DMWAS4Q DN BIS(12)-HUPERZINE B DMWAS4Q MI TT1RS9F DMWAS4Q MN Acetylcholinesterase (AChE) DMWAS4Q MT DTT DMWAS4Q MA Inhibitor DMWAS4Q RN Bis-huperzine B: highly potent and selective acetylcholinesterase inhibitors. J Med Chem. 2005 Feb 10;48(3):655-7. DMWAS4Q RU https://pubmed.ncbi.nlm.nih.gov/15689148 DM58YDV DI DM58YDV DM58YDV DN Bis(14)-Huperzine B DM58YDV MI TT1RS9F DM58YDV MN Acetylcholinesterase (AChE) DM58YDV MT DTT DM58YDV MA Inhibitor DM58YDV RN Bis-huperzine B: highly potent and selective acetylcholinesterase inhibitors. J Med Chem. 2005 Feb 10;48(3):655-7. DM58YDV RU https://pubmed.ncbi.nlm.nih.gov/15689148 DMYQM3B DI DMYQM3B DMYQM3B DN BIS(16)-HUPERZINE B DMYQM3B MI TT1RS9F DMYQM3B MN Acetylcholinesterase (AChE) DMYQM3B MT DTT DMYQM3B MA Inhibitor DMYQM3B RN Bis-huperzine B: highly potent and selective acetylcholinesterase inhibitors. J Med Chem. 2005 Feb 10;48(3):655-7. DMYQM3B RU https://pubmed.ncbi.nlm.nih.gov/15689148 DM3W1T4 DI DM3W1T4 DM3W1T4 DN BIS(18)-HUPERZINE B DM3W1T4 MI TT1RS9F DM3W1T4 MN Acetylcholinesterase (AChE) DM3W1T4 MT DTT DM3W1T4 MA Inhibitor DM3W1T4 RN Bis-huperzine B: highly potent and selective acetylcholinesterase inhibitors. J Med Chem. 2005 Feb 10;48(3):655-7. DM3W1T4 RU https://pubmed.ncbi.nlm.nih.gov/15689148 DMQ7KR1 DI DMQ7KR1 DMQ7KR1 DN Bis(2,3-dibromo-4,5-dihydroxyphenyl)ether DMQ7KR1 MI TT58ZYW DMQ7KR1 MN Mycobacterium Isocitrate lyase (MycB icl) DMQ7KR1 MT DTT DMQ7KR1 MA Inhibitor DMQ7KR1 RN Bromophenols as Candida albicans isocitrate lyase inhibitors. Bioorg Med Chem Lett. 2010 Nov 15;20(22):6644-8. DMQ7KR1 RU https://pubmed.ncbi.nlm.nih.gov/20888765 DMEW49T DI DMEW49T DMEW49T DN Bis(2,4-dinitrophenyl)sulfane DMEW49T MI TTR7UJ3 DMEW49T MN Cytoplasmic thioredoxin reductase (TXNRD1) DMEW49T MT DTT DMEW49T MA Inhibitor DMEW49T RN Specific inhibitors of Plasmodium falciparum thioredoxin reductase as potential antimalarial agents. Bioorg Med Chem Lett. 2006 Apr 15;16(8):2283-92. DMEW49T RU https://pubmed.ncbi.nlm.nih.gov/16458512 DMHQKCJ DI DMHQKCJ DMHQKCJ DN BIS(20)-HUPERZINE B DMHQKCJ MI TT1RS9F DMHQKCJ MN Acetylcholinesterase (AChE) DMHQKCJ MT DTT DMHQKCJ MA Inhibitor DMHQKCJ RN Bis-huperzine B: highly potent and selective acetylcholinesterase inhibitors. J Med Chem. 2005 Feb 10;48(3):655-7. DMHQKCJ RU https://pubmed.ncbi.nlm.nih.gov/15689148 DMKANOH DI DMKANOH DMKANOH DN Bis(31/31')[[Cys(31), Nva(34)]NPY(27-36)-NH(2)] DMKANOH MI TTKAPQ1 DMKANOH MN Cholecystokinin receptor (CCKR) DMKANOH MT DTT DMKANOH MA Antagonist DMKANOH RN Cholecystokinin receptor antagonist, loxiglumide, inhibits invasiveness of human pancreatic cancer cell lines. FEBS Lett. 1996 Apr 1;383(3):241-4. DMKANOH RU https://pubmed.ncbi.nlm.nih.gov/8925905 DMKANOH DI DMKANOH DMKANOH DN Bis(31/31')[[Cys(31), Nva(34)]NPY(27-36)-NH(2)] DMKANOH MI TTCG0AL DMKANOH MN Cholecystokinin receptor type A (CCKAR) DMKANOH MT DTT DMKANOH MA Antagonist DMKANOH RN Role of CCK(A) receptors in postprandial lower esophageal sphincter function in morbidly obese subjects. Dig Dis Sci. 2002 Nov;47(11):2531-7. DMKANOH RU https://pubmed.ncbi.nlm.nih.gov/12452391 DMKANOH DI DMKANOH DMKANOH DN Bis(31/31')[[Cys(31), Nva(34)]NPY(27-36)-NH(2)] DMKANOH MI TTY6EWA DMKANOH MN Neuropeptide Y receptor type 5 (NPY5R) DMKANOH MT DTT DMKANOH MA Agonist DMKANOH RN Bis(31/31')[[Cys(31), Nva(34)]NPY(27-36)-NH(2)]: a neuropeptide Y (NPY) Y(5) receptor selective agonist with a latent stimulatory effect on food intake in rats. Peptides. 2002 Aug;23(8):1485-90. DMKANOH RU https://pubmed.ncbi.nlm.nih.gov/12182951 DMUN50H DI DMUN50H DMUN50H DN Bis(3-bromo-4,5-dihydroxyphenyl)methanone DMUN50H MI TT58ZYW DMUN50H MN Mycobacterium Isocitrate lyase (MycB icl) DMUN50H MT DTT DMUN50H MA Inhibitor DMUN50H RN Bromophenols as Candida albicans isocitrate lyase inhibitors. Bioorg Med Chem Lett. 2010 Nov 15;20(22):6644-8. DMUN50H RU https://pubmed.ncbi.nlm.nih.gov/20888765 DM784AU DI DM784AU DM784AU DN Bis(3-bromophenyl)(4-hydroxy)thiosemicarbazone DM784AU MI TTF2LRI DM784AU MN Cathepsin B (CTSB) DM784AU MT DTT DM784AU MA Inhibitor DM784AU RN Functionalized benzophenone, thiophene, pyridine, and fluorene thiosemicarbazone derivatives as inhibitors of cathepsin L. Bioorg Med Chem Lett. 2010 Nov 15;20(22):6610-5. DM784AU RU https://pubmed.ncbi.nlm.nih.gov/20933415 DM784AU DI DM784AU DM784AU DN Bis(3-bromophenyl)(4-hydroxy)thiosemicarbazone DM784AU MI TT36ETB DM784AU MN Cathepsin L (CTSL) DM784AU MT DTT DM784AU MA Inhibitor DM784AU RN Functionalized benzophenone, thiophene, pyridine, and fluorene thiosemicarbazone derivatives as inhibitors of cathepsin L. Bioorg Med Chem Lett. 2010 Nov 15;20(22):6610-5. DM784AU RU https://pubmed.ncbi.nlm.nih.gov/20933415 DMASNGX DI DMASNGX DMASNGX DN Bis(3-bromophenyl)(5-hydroxy)thiosemicarbazone DMASNGX MI TT36ETB DMASNGX MN Cathepsin L (CTSL) DMASNGX MT DTT DMASNGX MA Inhibitor DMASNGX RN Functionalized benzophenone, thiophene, pyridine, and fluorene thiosemicarbazone derivatives as inhibitors of cathepsin L. Bioorg Med Chem Lett. 2010 Nov 15;20(22):6610-5. DMASNGX RU https://pubmed.ncbi.nlm.nih.gov/20933415 DMMJ635 DI DMMJ635 DMMJ635 DN Bis(3-Fluorophenyl)-ketone]thiosemicarbazone DMMJ635 MI TT36ETB DMMJ635 MN Cathepsin L (CTSL) DMMJ635 MT DTT DMMJ635 MA Inhibitor DMMJ635 RN Design, synthesis, and biological evaluation of potent thiosemicarbazone based cathepsin L inhibitors. Bioorg Med Chem Lett. 2010 Feb 15;20(4):1415-9. DMMJ635 RU https://pubmed.ncbi.nlm.nih.gov/20089402 DMO6HWJ DI DMO6HWJ DMO6HWJ DN Bis(4-fluorophenyl)-2-fluorophenylacetamide DMO6HWJ MI TTMNI76 DMO6HWJ MN Calcium-activated potassium channel (KCN) DMO6HWJ MT DTT DMO6HWJ MA Inhibitor DMO6HWJ RN Novel inhibitors of the Gardos channel for the treatment of sickle cell disease. J Med Chem. 2008 Feb 28;51(4):976-82. DMO6HWJ RU https://pubmed.ncbi.nlm.nih.gov/18232633 DM36VKH DI DM36VKH DM36VKH DN Bis(5-acetoxybenzo[b]furan-2-yl)methanone DM36VKH MI TTGJCWZ DM36VKH MN Fms-like tyrosine kinase 3 (FLT-3) DM36VKH MT DTT DM36VKH MA Inhibitor DM36VKH RN Inhibition of FLT3 and PDGFR tyrosine kinase activity by bis(benzo[b]furan-2-yl)methanones. Bioorg Med Chem. 2007 Mar 1;15(5):2187-97. DM36VKH RU https://pubmed.ncbi.nlm.nih.gov/17210255 DM36VKH DI DM36VKH DM36VKH DN Bis(5-acetoxybenzo[b]furan-2-yl)methanone DM36VKH MI TTI7421 DM36VKH MN Platelet-derived growth factor receptor beta (PDGFRB) DM36VKH MT DTT DM36VKH MA Inhibitor DM36VKH RN Inhibition of FLT3 and PDGFR tyrosine kinase activity by bis(benzo[b]furan-2-yl)methanones. Bioorg Med Chem. 2007 Mar 1;15(5):2187-97. DM36VKH RU https://pubmed.ncbi.nlm.nih.gov/17210255 DMHRGTY DI DMHRGTY DMHRGTY DN Bis(5-aminobenzo[b]furan-2-yl)methanone DMHRGTY MI TTGJCWZ DMHRGTY MN Fms-like tyrosine kinase 3 (FLT-3) DMHRGTY MT DTT DMHRGTY MA Inhibitor DMHRGTY RN Inhibition of FLT3 and PDGFR tyrosine kinase activity by bis(benzo[b]furan-2-yl)methanones. Bioorg Med Chem. 2007 Mar 1;15(5):2187-97. DMHRGTY RU https://pubmed.ncbi.nlm.nih.gov/17210255 DMHRGTY DI DMHRGTY DMHRGTY DN Bis(5-aminobenzo[b]furan-2-yl)methanone DMHRGTY MI TTI7421 DMHRGTY MN Platelet-derived growth factor receptor beta (PDGFRB) DMHRGTY MT DTT DMHRGTY MA Inhibitor DMHRGTY RN Inhibition of FLT3 and PDGFR tyrosine kinase activity by bis(benzo[b]furan-2-yl)methanones. Bioorg Med Chem. 2007 Mar 1;15(5):2187-97. DMHRGTY RU https://pubmed.ncbi.nlm.nih.gov/17210255 DMTSEXB DI DMTSEXB DMTSEXB DN Bis-(5-hydroxy-1H-indol-2-yl)-methanone DMTSEXB MI TTGJCWZ DMTSEXB MN Fms-like tyrosine kinase 3 (FLT-3) DMTSEXB MT DTT DMTSEXB MA Inhibitor DMTSEXB RN Novel bis(1H-indol-2-yl)methanones as potent inhibitors of FLT3 and platelet-derived growth factor receptor tyrosine kinase. J Med Chem. 2006 Jun 1;49(11):3101-15. DMTSEXB RU https://pubmed.ncbi.nlm.nih.gov/16722630 DMTSEXB DI DMTSEXB DMTSEXB DN Bis-(5-hydroxy-1H-indol-2-yl)-methanone DMTSEXB MI TT8FYO9 DMTSEXB MN Platelet-derived growth factor receptor alpha (PDGFRA) DMTSEXB MT DTT DMTSEXB MA Inhibitor DMTSEXB RN Novel bis(1H-indol-2-yl)methanones as potent inhibitors of FLT3 and platelet-derived growth factor receptor tyrosine kinase. J Med Chem. 2006 Jun 1;49(11):3101-15. DMTSEXB RU https://pubmed.ncbi.nlm.nih.gov/16722630 DMTSEXB DI DMTSEXB DMTSEXB DN Bis-(5-hydroxy-1H-indol-2-yl)-methanone DMTSEXB MI TTI7421 DMTSEXB MN Platelet-derived growth factor receptor beta (PDGFRB) DMTSEXB MT DTT DMTSEXB MA Inhibitor DMTSEXB RN Novel bis(1H-indol-2-yl)methanones as potent inhibitors of FLT3 and platelet-derived growth factor receptor tyrosine kinase. J Med Chem. 2006 Jun 1;49(11):3101-15. DMTSEXB RU https://pubmed.ncbi.nlm.nih.gov/16722630 DMTSEXB DI DMTSEXB DMTSEXB DN Bis-(5-hydroxy-1H-indol-2-yl)-methanone DMTSEXB MI TT3PJMV DMTSEXB MN Tyrosine-protein kinase ABL1 (ABL) DMTSEXB MT DTT DMTSEXB MA Inhibitor DMTSEXB RN Novel bis(1H-indol-2-yl)methanones as potent inhibitors of FLT3 and platelet-derived growth factor receptor tyrosine kinase. J Med Chem. 2006 Jun 1;49(11):3101-15. DMTSEXB RU https://pubmed.ncbi.nlm.nih.gov/16722630 DMTSEXB DI DMTSEXB DMTSEXB DN Bis-(5-hydroxy-1H-indol-2-yl)-methanone DMTSEXB MI TTX41N9 DMTSEXB MN Tyrosine-protein kinase Kit (KIT) DMTSEXB MT DTT DMTSEXB MA Inhibitor DMTSEXB RN Novel bis(1H-indol-2-yl)methanones as potent inhibitors of FLT3 and platelet-derived growth factor receptor tyrosine kinase. J Med Chem. 2006 Jun 1;49(11):3101-15. DMTSEXB RU https://pubmed.ncbi.nlm.nih.gov/16722630 DMGRKDP DI DMGRKDP DMGRKDP DN Bis(5-hydroxybenzo[b]furan-2-yl)methanone DMGRKDP MI TTGJCWZ DMGRKDP MN Fms-like tyrosine kinase 3 (FLT-3) DMGRKDP MT DTT DMGRKDP MA Inhibitor DMGRKDP RN Inhibition of FLT3 and PDGFR tyrosine kinase activity by bis(benzo[b]furan-2-yl)methanones. Bioorg Med Chem. 2007 Mar 1;15(5):2187-97. DMGRKDP RU https://pubmed.ncbi.nlm.nih.gov/17210255 DMGRKDP DI DMGRKDP DMGRKDP DN Bis(5-hydroxybenzo[b]furan-2-yl)methanone DMGRKDP MI TTI7421 DMGRKDP MN Platelet-derived growth factor receptor beta (PDGFRB) DMGRKDP MT DTT DMGRKDP MA Inhibitor DMGRKDP RN Inhibition of FLT3 and PDGFR tyrosine kinase activity by bis(benzo[b]furan-2-yl)methanones. Bioorg Med Chem. 2007 Mar 1;15(5):2187-97. DMGRKDP RU https://pubmed.ncbi.nlm.nih.gov/17210255 DM9XC6A DI DM9XC6A DM9XC6A DN Bis(5-methoxybenzo[b]furan-2-yl)methanone DM9XC6A MI TTI7421 DM9XC6A MN Platelet-derived growth factor receptor beta (PDGFRB) DM9XC6A MT DTT DM9XC6A MA Inhibitor DM9XC6A RN Inhibition of FLT3 and PDGFR tyrosine kinase activity by bis(benzo[b]furan-2-yl)methanones. Bioorg Med Chem. 2007 Mar 1;15(5):2187-97. DM9XC6A RU https://pubmed.ncbi.nlm.nih.gov/17210255 DMQ98H5 DI DMQ98H5 DMQ98H5 DN Bis-(5-pyridin-3-yl-thiophen-2-ylmethyl)-amine DMQ98H5 MI TTVG215 DMQ98H5 MN Debrisoquine 4-hydroxylase (CYP2D6) DMQ98H5 MT DTT DMQ98H5 MA Inhibitor DMQ98H5 RN 5-substituted, 6-substituted, and unsubstituted 3-heteroaromatic pyridine analogues of nicotine as selective inhibitors of cytochrome P-450 2A6. J Med Chem. 2005 Jan 13;48(1):224-39. DMQ98H5 RU https://pubmed.ncbi.nlm.nih.gov/15634016 DMRGNSQ DI DMRGNSQ DMRGNSQ DN Bis(6-hydroxybenzo[b]furan-2-yl)methanone DMRGNSQ MI TTGJCWZ DMRGNSQ MN Fms-like tyrosine kinase 3 (FLT-3) DMRGNSQ MT DTT DMRGNSQ MA Inhibitor DMRGNSQ RN Inhibition of FLT3 and PDGFR tyrosine kinase activity by bis(benzo[b]furan-2-yl)methanones. Bioorg Med Chem. 2007 Mar 1;15(5):2187-97. DMRGNSQ RU https://pubmed.ncbi.nlm.nih.gov/17210255 DMRGNSQ DI DMRGNSQ DMRGNSQ DN Bis(6-hydroxybenzo[b]furan-2-yl)methanone DMRGNSQ MI TTI7421 DMRGNSQ MN Platelet-derived growth factor receptor beta (PDGFRB) DMRGNSQ MT DTT DMRGNSQ MA Inhibitor DMRGNSQ RN Inhibition of FLT3 and PDGFR tyrosine kinase activity by bis(benzo[b]furan-2-yl)methanones. Bioorg Med Chem. 2007 Mar 1;15(5):2187-97. DMRGNSQ RU https://pubmed.ncbi.nlm.nih.gov/17210255 DMER5GT DI DMER5GT DMER5GT DN BIS(8)-HUPERZINE B DMER5GT MI TT1RS9F DMER5GT MN Acetylcholinesterase (AChE) DMER5GT MT DTT DMER5GT MA Inhibitor DMER5GT RN Bis-huperzine B: highly potent and selective acetylcholinesterase inhibitors. J Med Chem. 2005 Feb 10;48(3):655-7. DMER5GT RU https://pubmed.ncbi.nlm.nih.gov/15689148 DM5WFQM DI DM5WFQM DM5WFQM DN BIS(9)-HUPERZINE B DM5WFQM MI TT1RS9F DM5WFQM MN Acetylcholinesterase (AChE) DM5WFQM MT DTT DM5WFQM MA Inhibitor DM5WFQM RN Bis-huperzine B: highly potent and selective acetylcholinesterase inhibitors. J Med Chem. 2005 Feb 10;48(3):655-7. DM5WFQM RU https://pubmed.ncbi.nlm.nih.gov/15689148 DMK2ZG4 DI DMK2ZG4 DMK2ZG4 DN Bis(benzo[b]furan-2-yl)methanone DMK2ZG4 MI TTGJCWZ DMK2ZG4 MN Fms-like tyrosine kinase 3 (FLT-3) DMK2ZG4 MT DTT DMK2ZG4 MA Inhibitor DMK2ZG4 RN Inhibition of FLT3 and PDGFR tyrosine kinase activity by bis(benzo[b]furan-2-yl)methanones. Bioorg Med Chem. 2007 Mar 1;15(5):2187-97. DMK2ZG4 RU https://pubmed.ncbi.nlm.nih.gov/17210255 DMK2ZG4 DI DMK2ZG4 DMK2ZG4 DN Bis(benzo[b]furan-2-yl)methanone DMK2ZG4 MI TTI7421 DMK2ZG4 MN Platelet-derived growth factor receptor beta (PDGFRB) DMK2ZG4 MT DTT DMK2ZG4 MA Inhibitor DMK2ZG4 RN Inhibition of FLT3 and PDGFR tyrosine kinase activity by bis(benzo[b]furan-2-yl)methanones. Bioorg Med Chem. 2007 Mar 1;15(5):2187-97. DMK2ZG4 RU https://pubmed.ncbi.nlm.nih.gov/17210255 DMYSQ2B DI DMYSQ2B DMYSQ2B DN Bis-{[R-(-)-apomorphine-2-oxy]ethyl} ether DMYSQ2B MI TTEX248 DMYSQ2B MN Dopamine D2 receptor (D2R) DMYSQ2B MT DTT DMYSQ2B MA Inhibitor DMYSQ2B RN Synthesis and neuropharmacological characterization of 2-O-substituted apomorphines. Bioorg Med Chem. 2008 Apr 15;16(8):4563-8. DMYSQ2B RU https://pubmed.ncbi.nlm.nih.gov/18313931 DMVNC1R DI DMVNC1R DMVNC1R DN Bis-7-tacrine DMVNC1R MI TT1RS9F DMVNC1R MN Acetylcholinesterase (AChE) DMVNC1R MT DTT DMVNC1R MA Inhibitor DMVNC1R RN Design, synthesis and evaluation of 2,4-disubstituted pyrimidines as cholinesterase inhibitors. Bioorg Med Chem Lett. 2010 Jun 15;20(12):3606-9. DMVNC1R RU https://pubmed.ncbi.nlm.nih.gov/20472431 DMVNC1R DI DMVNC1R DMVNC1R DN Bis-7-tacrine DMVNC1R MI TT8JRS7 DMVNC1R MN Beta-secretase (BACE) DMVNC1R MT DTT DMVNC1R MA Inhibitor DMVNC1R RN Pyrano[3,2-c]quinoline-6-chlorotacrine hybrids as a novel family of acetylcholinesterase- and beta-amyloid-directed anti-Alzheimer compounds. J Med Chem. 2009 Sep 10;52(17):5365-79. DMVNC1R RU https://pubmed.ncbi.nlm.nih.gov/19663388 DMVNC1R DI DMVNC1R DMVNC1R DN Bis-7-tacrine DMVNC1R MI TTEB0GD DMVNC1R MN Cholinesterase (BCHE) DMVNC1R MT DTT DMVNC1R MA Inhibitor DMVNC1R RN Design, synthesis and evaluation of 2,4-disubstituted pyrimidines as cholinesterase inhibitors. Bioorg Med Chem Lett. 2010 Jun 15;20(12):3606-9. DMVNC1R RU https://pubmed.ncbi.nlm.nih.gov/20472431 DMRSKGC DI DMRSKGC DMRSKGC DN bisandrographolide DMRSKGC MI TTKP2SU DMRSKGC MN Transient receptor potential cation channel V4 (TRPV4) DMRSKGC MT DTT DMRSKGC MA Activator DMRSKGC RN Bisandrographolide from Andrographis paniculata activates TRPV4 channels. J Biol Chem. 2006 Oct 6;281(40):29897-904. DMRSKGC RU https://pubmed.ncbi.nlm.nih.gov/16899456 DMF4AHD DI DMF4AHD DMF4AHD DN Bis-cyclosal-d4TMP DMF4AHD MI TTEB0GD DMF4AHD MN Cholinesterase (BCHE) DMF4AHD MT DTT DMF4AHD MA Inhibitor DMF4AHD RN Bis-cycloSal-d4T-monophosphates: drugs that deliver two molecules of bioactive nucleotides. J Med Chem. 2007 Mar 22;50(6):1335-46. DMF4AHD RU https://pubmed.ncbi.nlm.nih.gov/17328534 DMVRXH3 DI DMVRXH3 DMVRXH3 DN Bishydroxy[2h-1-Benzopyran-2-One,1,2-Benzopyrone] DMVRXH3 MI TT8XK6L DMVRXH3 MN Quinone reductase 1 (NQO1) DMVRXH3 MT DTT DMVRXH3 MA Inhibitor DMVRXH3 RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMVRXH3 RU https://pubmed.ncbi.nlm.nih.gov/17139284 DM0MK6D DI DM0MK6D DM0MK6D DN BIS-IMIDE A DM0MK6D MI TTTU902 DM0MK6D MN Checkpoint kinase-1 (CHK1) DM0MK6D MT DTT DM0MK6D MA Inhibitor DM0MK6D RN Synthesis, in vitro antiproliferative activities, and Chk1 inhibitory properties of pyrrolo[3,4-a]carbazole-1,3-diones, pyrrolo[3,4-c]carbazole-1,3... Eur J Med Chem. 2008 Feb;43(2):282-92. DM0MK6D RU https://pubmed.ncbi.nlm.nih.gov/17502122 DMOQJZC DI DMOQJZC DMOQJZC DN Bisindolylmaleimide-I DMOQJZC MI TTIQSC1 DMOQJZC MN Bacterial Lethal factor (Bact lef) DMOQJZC MT DTT DMOQJZC MA Inhibitor DMOQJZC RN Amiodarone and bepridil inhibit anthrax toxin entry into host cells. Antimicrob Agents Chemother. 2007 Jul;51(7):2403-11. DMOQJZC RU https://pubmed.ncbi.nlm.nih.gov/17485504 DMOQJZC DI DMOQJZC DMOQJZC DN Bisindolylmaleimide-I DMOQJZC MI TTTU902 DMOQJZC MN Checkpoint kinase-1 (CHK1) DMOQJZC MT DTT DMOQJZC MA Inhibitor DMOQJZC RN Specificity and mechanism of action of some commonly used protein kinase inhibitors. Biochem J. 2000 Oct 1;351(Pt 1):95-105. DMOQJZC RU https://pubmed.ncbi.nlm.nih.gov/10998351 DMOQJZC DI DMOQJZC DMOQJZC DN Bisindolylmaleimide-I DMOQJZC MI TTH6V3D DMOQJZC MN Cyclin-dependent kinase 1 (CDK1) DMOQJZC MT DTT DMOQJZC MA Inhibitor DMOQJZC RN Design of new inhibitors for cdc2 kinase based on a multiple pseudosubstrate structure. Bioorg Med Chem Lett. 1998 May 5;8(9):1019-22. DMOQJZC RU https://pubmed.ncbi.nlm.nih.gov/9871700 DMOQJZC DI DMOQJZC DMOQJZC DN Bisindolylmaleimide-I DMOQJZC MI TT4TQBX DMOQJZC MN Extracellular signal-regulated kinase 2 (ERK2) DMOQJZC MT DTT DMOQJZC MA Inhibitor DMOQJZC RN Specificity and mechanism of action of some commonly used protein kinase inhibitors. Biochem J. 2000 Oct 1;351(Pt 1):95-105. DMOQJZC RU https://pubmed.ncbi.nlm.nih.gov/10998351 DMOQJZC DI DMOQJZC DMOQJZC DN Bisindolylmaleimide-I DMOQJZC MI TT9P6OW DMOQJZC MN G2/mitotic-specific cyclin B1 (CCNB1) DMOQJZC MT DTT DMOQJZC MA Inhibitor DMOQJZC RN Design of new inhibitors for cdc2 kinase based on a multiple pseudosubstrate structure. Bioorg Med Chem Lett. 1998 May 5;8(9):1019-22. DMOQJZC RU https://pubmed.ncbi.nlm.nih.gov/9871700 DMOQJZC DI DMOQJZC DMOQJZC DN Bisindolylmaleimide-I DMOQJZC MI TTRSMW9 DMOQJZC MN Glycogen synthase kinase-3 beta (GSK-3B) DMOQJZC MT DTT DMOQJZC MA Inhibitor DMOQJZC RN Specificity and mechanism of action of some commonly used protein kinase inhibitors. Biochem J. 2000 Oct 1;351(Pt 1):95-105. DMOQJZC RU https://pubmed.ncbi.nlm.nih.gov/10998351 DMOQJZC DI DMOQJZC DMOQJZC DN Bisindolylmaleimide-I DMOQJZC MI TT860QF DMOQJZC MN LCK tyrosine protein kinase (LCK) DMOQJZC MT DTT DMOQJZC MA Inhibitor DMOQJZC RN Specificity and mechanism of action of some commonly used protein kinase inhibitors. Biochem J. 2000 Oct 1;351(Pt 1):95-105. DMOQJZC RU https://pubmed.ncbi.nlm.nih.gov/10998351 DMOQJZC DI DMOQJZC DMOQJZC DN Bisindolylmaleimide-I DMOQJZC MI TTYT93M DMOQJZC MN MAP kinase p38 (MAPK12) DMOQJZC MT DTT DMOQJZC MA Inhibitor DMOQJZC RN Specificity and mechanism of action of some commonly used protein kinase inhibitors. Biochem J. 2000 Oct 1;351(Pt 1):95-105. DMOQJZC RU https://pubmed.ncbi.nlm.nih.gov/10998351 DMOQJZC DI DMOQJZC DMOQJZC DN Bisindolylmaleimide-I DMOQJZC MI TT7A1BO DMOQJZC MN PKC-delta messenger RNA (PRKCD mRNA) DMOQJZC MT DTT DMOQJZC MA Inhibitor DMOQJZC RN Protein kinase C epsilon regulates gamma-aminobutyrate type A receptor sensitivity to ethanol and benzodiazepines through phosphorylation of gamma2... J Biol Chem. 2007 Nov 9;282(45):33052-63. DMOQJZC RU https://pubmed.ncbi.nlm.nih.gov/17875639 DMOQJZC DI DMOQJZC DMOQJZC DN Bisindolylmaleimide-I DMOQJZC MI TT57MT2 DMOQJZC MN PKC-epsilon messenger RNA (PRKCE mRNA) DMOQJZC MT DTT DMOQJZC MA Inhibitor DMOQJZC RN Protein kinase C epsilon regulates gamma-aminobutyrate type A receptor sensitivity to ethanol and benzodiazepines through phosphorylation of gamma2... J Biol Chem. 2007 Nov 9;282(45):33052-63. DMOQJZC RU https://pubmed.ncbi.nlm.nih.gov/17875639 DMOQJZC DI DMOQJZC DMOQJZC DN Bisindolylmaleimide-I DMOQJZC MI TTYVX59 DMOQJZC MN Protein kinase C (PRKC) DMOQJZC MT DTT DMOQJZC MA Inhibitor DMOQJZC RN Protein kinase epsilon dampens the secretory response of model intestinal epithelia during ischemia. Surgery. 2001 Aug;130(2):310-8. DMOQJZC RU https://pubmed.ncbi.nlm.nih.gov/11490365 DMOQJZC DI DMOQJZC DMOQJZC DN Bisindolylmaleimide-I DMOQJZC MI TTRFOXJ DMOQJZC MN Protein kinase C gamma (PRKCG) DMOQJZC MT DTT DMOQJZC MA Inhibitor DMOQJZC RN Protein kinase C epsilon regulates gamma-aminobutyrate type A receptor sensitivity to ethanol and benzodiazepines through phosphorylation of gamma2... J Biol Chem. 2007 Nov 9;282(45):33052-63. DMOQJZC RU https://pubmed.ncbi.nlm.nih.gov/17875639 DMOQJZC DI DMOQJZC DMOQJZC DN Bisindolylmaleimide-I DMOQJZC MI TTUWGRA DMOQJZC MN Protein kinase C zeta (PRKCZ) DMOQJZC MT DTT DMOQJZC MA Inhibitor DMOQJZC RN Protein kinase C zeta isoform is critical for proliferation in human glioblastoma cell lines. J Neurooncol. 2000 Apr;47(2):109-15. DMOQJZC RU https://pubmed.ncbi.nlm.nih.gov/10982151 DMOQJZC DI DMOQJZC DMOQJZC DN Bisindolylmaleimide-I DMOQJZC MI TTWTSCV DMOQJZC MN RAC-alpha serine/threonine-protein kinase (AKT1) DMOQJZC MT DTT DMOQJZC MA Inhibitor DMOQJZC RN Specificity and mechanism of action of some commonly used protein kinase inhibitors. Biochem J. 2000 Oct 1;351(Pt 1):95-105. DMOQJZC RU https://pubmed.ncbi.nlm.nih.gov/10998351 DMOQJZC DI DMOQJZC DMOQJZC DN Bisindolylmaleimide-I DMOQJZC MI TTZN7RP DMOQJZC MN Rho-associated protein kinase 1 (ROCK1) DMOQJZC MT DTT DMOQJZC MA Inhibitor DMOQJZC RN Specificity and mechanism of action of some commonly used protein kinase inhibitors. Biochem J. 2000 Oct 1;351(Pt 1):95-105. DMOQJZC RU https://pubmed.ncbi.nlm.nih.gov/10998351 DMOQJZC DI DMOQJZC DMOQJZC DN Bisindolylmaleimide-I DMOQJZC MI TTTV8EJ DMOQJZC MN Serine/threonine-protein kinase Sgk1 (SGK1) DMOQJZC MT DTT DMOQJZC MA Inhibitor DMOQJZC RN Specificity and mechanism of action of some commonly used protein kinase inhibitors. Biochem J. 2000 Oct 1;351(Pt 1):95-105. DMOQJZC RU https://pubmed.ncbi.nlm.nih.gov/10998351 DMOQJZC DI DMOQJZC DMOQJZC DN Bisindolylmaleimide-I DMOQJZC MI TTQBR95 DMOQJZC MN Stress-activated protein kinase 2a (p38 alpha) DMOQJZC MT DTT DMOQJZC MA Inhibitor DMOQJZC RN Specificity and mechanism of action of some commonly used protein kinase inhibitors. Biochem J. 2000 Oct 1;351(Pt 1):95-105. DMOQJZC RU https://pubmed.ncbi.nlm.nih.gov/10998351 DMOQJZC DI DMOQJZC DMOQJZC DN Bisindolylmaleimide-I DMOQJZC MI TT73U6C DMOQJZC MN Stress-activated protein kinase 2b (p38 beta) DMOQJZC MT DTT DMOQJZC MA Inhibitor DMOQJZC RN Specificity and mechanism of action of some commonly used protein kinase inhibitors. Biochem J. 2000 Oct 1;351(Pt 1):95-105. DMOQJZC RU https://pubmed.ncbi.nlm.nih.gov/10998351 DMOQJZC DI DMOQJZC DMOQJZC DN Bisindolylmaleimide-I DMOQJZC MI TT0K6EO DMOQJZC MN Stress-activated protein kinase JNK1 (JNK1) DMOQJZC MT DTT DMOQJZC MA Inhibitor DMOQJZC RN Specificity and mechanism of action of some commonly used protein kinase inhibitors. Biochem J. 2000 Oct 1;351(Pt 1):95-105. DMOQJZC RU https://pubmed.ncbi.nlm.nih.gov/10998351 DM0K6QH DI DM0K6QH DM0K6QH DN Bis-Napthyl Beta-Ketophosphonic Acid DM0K6QH MI TTQAJF1 DM0K6QH MN Cathepsin G (CTSG) DM0K6QH MT DTT DM0K6QH MA Inhibitor DM0K6QH RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DM0K6QH RU https://pubmed.ncbi.nlm.nih.gov/17139284 DM2ZLD7 DI DM2ZLD7 DM2ZLD7 DN Bisphenol A DM2ZLD7 MI TTKPW01 DM2ZLD7 MN Androgen receptor messenger RNA (AR mRNA) DM2ZLD7 MT DTT DM2ZLD7 MA Antagonist DM2ZLD7 RN Structure-activity relationships of bisphenol A analogs at estrogen receptors (ERs): discovery of an ERalpha-selective antagonist. Bioorg Med Chem Lett. 2013 Jul 15;23(14):4031-6. DM2ZLD7 RU https://pubmed.ncbi.nlm.nih.gov/23768907 DM2ZLD7 DI DM2ZLD7 DM2ZLD7 DN Bisphenol A DM2ZLD7 MI TTOM3J0 DM2ZLD7 MN Estrogen receptor beta (ESR2) DM2ZLD7 MT DTT DM2ZLD7 MA Agonist DM2ZLD7 RN Structure-activity relationships of bisphenol A analogs at estrogen receptors (ERs): discovery of an ERalpha-selective antagonist. Bioorg Med Chem Lett. 2013 Jul 15;23(14):4031-6. DM2ZLD7 RU https://pubmed.ncbi.nlm.nih.gov/23768907 DM2ZLD7 DI DM2ZLD7 DM2ZLD7 DN Bisphenol A DM2ZLD7 MI DE0P6LK DM2ZLD7 MN Sulfotransferase 2A1 (SULT2A1) DM2ZLD7 MT DME DM2ZLD7 MA Metabolism DM2ZLD7 RN Sulfation of environmental estrogens by cytosolic human sulfotransferases. Drug Metab Pharmacokinet. 2002;17(3):221-8. DM2ZLD7 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=15618673 DMFHY04 DI DMFHY04 DMFHY04 DN BIX 02188 DMFHY04 MI TTV3O87 DMFHY04 MN ERK activator kinase 5 (MAP2K5) DMFHY04 MT DTT DMFHY04 MA Inhibitor DMFHY04 RN Identification of pharmacological inhibitors of the MEK5/ERK5 pathway. Biochem Biophys Res Commun. 2008 Dec 5;377(1):120-5. DMFHY04 RU https://pubmed.ncbi.nlm.nih.gov/18834865 DMNAX1Q DI DMNAX1Q DMNAX1Q DN BIX 02565 DMNAX1Q MI TTUM2ZR DMNAX1Q MN Ribosomal protein S6 kinase alpha-3 (RSK3) DMNAX1Q MT DTT DMNAX1Q MA Inhibitor DMNAX1Q RN Indole RSK inhibitors. Part 2: optimization of cell potency and kinase selectivity. Bioorg Med Chem Lett. 2012 Jan 1;22(1):738-42. DMNAX1Q RU https://pubmed.ncbi.nlm.nih.gov/22056746 DMGULNZ DI DMGULNZ DMGULNZ DN BL-5040 DMGULNZ MI TT0HD6V DMGULNZ MN Leptin receptor (LEPR) DMGULNZ MT DTT DMGULNZ MA Antagonist DMGULNZ RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1712). DMGULNZ RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1712 DMQLJMC DI DMQLJMC DMQLJMC DN BL-6020 DMQLJMC MI TTD0CIQ DMQLJMC MN Melanocortin receptor 4 (MC4R) DMQLJMC MT DTT DMQLJMC MA Antagonist DMQLJMC RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 285). DMQLJMC RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=285 DMBRZ4P DI DMBRZ4P DMBRZ4P DN BLV-0703 DMBRZ4P MI TTS87KH DMBRZ4P MN Microtubule-associated protein tau (MAPT) DMBRZ4P MT DTT DMBRZ4P MA Modulator DMBRZ4P RN Microtubules (tau) as an emerging therapeutic target: NAP (davunetide). Curr Pharm Des. 2011;17(31):3413-7. DMBRZ4P RU https://pubmed.ncbi.nlm.nih.gov/21902667 DMGB9PN DI DMGB9PN DMGB9PN DN BLV-0801 DMGB9PN MI TTZJYKH DMGB9PN MN Indoleamine 2,3-dioxygenase 1 (IDO1) DMGB9PN MT DTT DMGB9PN MA Inhibitor DMGB9PN RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2829). DMGB9PN RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2829 DM728RW DI DM728RW DM728RW DN BLX-301 DM728RW MI TTUE541 DM728RW MN Leukocyte surface antigen Leu-16 (CD20) DM728RW MT DTT DM728RW RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2628). DM728RW RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2628 DMDNPML DI DMDNPML DMDNPML DN BM-162115 DMDNPML MI TT9V5JH DMDNPML MN Phospholipase A2 (PLA2G1B) DMDNPML MT DTT DMDNPML MA Inhibitor DMDNPML RN Investigation on the effect of experimental phospholipase A2 inhibitors on the formyl-methionyl-leucyl-phenylalanine-stimulated chemotaxis of human leukocytes in vitro. Arzneimittelforschung. 1998 Jan;48(1):77-81. DMDNPML RU https://pubmed.ncbi.nlm.nih.gov/9522038 DMD2H7L DI DMD2H7L DMD2H7L DN BM-573 DMD2H7L MI TT2O84V DMD2H7L MN Thromboxane A2 receptor (TBXA2R) DMD2H7L MT DTT DMD2H7L MA Inhibitor DMD2H7L RN Synthesis and pharmacological evaluation of novel nitrobenzenic thromboxane modulators as antiplatelet agents acting on both the alpha and beta iso... J Med Chem. 2006 Jun 15;49(12):3701-9. DMD2H7L RU https://pubmed.ncbi.nlm.nih.gov/16759113 DM8AEQX DI DM8AEQX DM8AEQX DN Bmab-200 DM8AEQX MI TTGKNB4 DM8AEQX MN Epidermal growth factor receptor (EGFR) DM8AEQX MT DTT DM8AEQX RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1797). DM8AEQX RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1797 DMER2WS DI DMER2WS DMER2WS DN BML3-C01 DMER2WS MI DE073H6 DMER2WS MN Prostaglandin G/H synthase 1 (COX-1) DMER2WS MT DME DMER2WS MA Metabolism DMER2WS RN Divergent cyclooxygenase responses to fatty acid structure and peroxide level in fish and mammalian prostaglandin H synthases. FASEB J. 2006 Jun;20(8):1097-108. DMER2WS RU https://www.ncbi.nlm.nih.gov/pubmed/?term=16770009 DMER2WS DI DMER2WS DMER2WS DN BML3-C01 DMER2WS MI DE492CE DMER2WS MN Prostaglandin G/H synthase 2 (COX-2) DMER2WS MT DME DMER2WS MA Metabolism DMER2WS RN Divergent cyclooxygenase responses to fatty acid structure and peroxide level in fish and mammalian prostaglandin H synthases. FASEB J. 2006 Jun;20(8):1097-108. DMER2WS RU https://www.ncbi.nlm.nih.gov/pubmed/?term=16770009 DMYWEO6 DI DMYWEO6 DMYWEO6 DN BMN-103 DMYWEO6 MI TTXWASR DMYWEO6 MN Intestinal maltase-glucoamylase (MGAM) DMYWEO6 MT DTT DMYWEO6 MA Modulator DMYWEO6 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2627). DMYWEO6 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2627 DM0VMZ4 DI DM0VMZ4 DM0VMZ4 DN BMN-168 DM0VMZ4 MI TTGSVH2 DM0VMZ4 MN Phenylalanine hydroxylase (PAH) DM0VMZ4 MT DTT DM0VMZ4 MA Modulator DM0VMZ4 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1240). DM0VMZ4 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1240 DMR82WI DI DMR82WI DMR82WI DN BMS compound 4c DMR82WI MI TTA93TL DMR82WI MN P2Y purinoceptor 1 (P2RY1) DMR82WI MT DTT DMR82WI MA Antagonist DMR82WI RN New azole antagonists with high affinity for the P2Y(1) receptor. Bioorg Med Chem Lett. 2013 Jun 15;23(12):3519-22. DMR82WI RU https://pubmed.ncbi.nlm.nih.gov/23668989 DMJM8OQ DI DMJM8OQ DMJM8OQ DN BMS pyrazole inhibitor 7f DMJM8OQ MI TTIZQFJ DMJM8OQ MN Histone-arginine methyltransferase CARM1 (CARM1) DMJM8OQ MT DTT DMJM8OQ MA Inhibitor DMJM8OQ RN Optimization of pyrazole inhibitors of Coactivator Associated Arginine Methyltransferase 1 (CARM1). Bioorg Med Chem Lett. 2009 Jun 1;19(11):2924-7. DMJM8OQ RU https://pubmed.ncbi.nlm.nih.gov/19419866 DM4D6ZB DI DM4D6ZB DM4D6ZB DN BMS-1 DM4D6ZB MI TTDP1UC DM4D6ZB MN Fatty acid amide hydrolase (FAAH) DM4D6ZB MT DTT DM4D6ZB MA Inhibitor DM4D6ZB RN Synthesis and evaluation of benzothiazole-based analogues as novel, potent, and selective fatty acid amide hydrolase inhibitors. J Med Chem. 2009 Jan 8;52(1):170-80. DM4D6ZB RU https://pubmed.ncbi.nlm.nih.gov/19072118 DMGE82R DI DMGE82R DMGE82R DN BMS184394 DMGE82R MI TT1Q3IE DMGE82R MN Retinoic acid receptor gamma (RARG) DMGE82R MT DTT DMGE82R MA Inhibitor DMGE82R RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMGE82R RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMJ218E DI DMJ218E DMJ218E DN BMS-187308 DMJ218E MI TTKRD0G DMJ218E MN Endothelin A receptor (EDNRA) DMJ218E MT DTT DMJ218E MA Modulator DMJ218E RN Biphenylsulfonamide endothelin antagonists: structure-activity relationships of a series of mono- and disubstituted analogues and pharmacology of t... J Med Chem. 1998 Dec 17;41(26):5198-218. DMJ218E RU https://www.ncbi.nlm.nih.gov/pubmed/9857090 DM7GUDC DI DM7GUDC DM7GUDC DN BMS-189323 DM7GUDC MI TTRK9JT DM7GUDC MN Neuropeptide Y receptor type 1 (NPY1R) DM7GUDC MT DTT DM7GUDC MA Inhibitor DM7GUDC RN Isosteric N-arylpiperazine replacements in a series of dihydropyridine NPY1 receptor antagonists. Bioorg Med Chem Lett. 2004 Dec 20;14(24):5975-8. DM7GUDC RU https://pubmed.ncbi.nlm.nih.gov/15546711 DM1ZBU3 DI DM1ZBU3 DM1ZBU3 DN BMS-193885 DM1ZBU3 MI TTRK9JT DM1ZBU3 MN Neuropeptide Y receptor type 1 (NPY1R) DM1ZBU3 MT DTT DM1ZBU3 MA Antagonist DM1ZBU3 RN Dihydropyridine neuropeptide Y Y(1) receptor antagonists. Bioorg Med Chem Lett. 2002 Feb 11;12(3):379-82. DM1ZBU3 RU https://pubmed.ncbi.nlm.nih.gov/11814801 DM5SNMQ DI DM5SNMQ DM5SNMQ DN BMS-245782 DM5SNMQ MI TTRK9JT DM5SNMQ MN Neuropeptide Y receptor type 1 (NPY1R) DM5SNMQ MT DTT DM5SNMQ MA Inhibitor DM5SNMQ RN Isosteric N-arylpiperazine replacements in a series of dihydropyridine NPY1 receptor antagonists. Bioorg Med Chem Lett. 2004 Dec 20;14(24):5975-8. DM5SNMQ RU https://pubmed.ncbi.nlm.nih.gov/15546711 DMETNA3 DI DMETNA3 DMETNA3 DN BMS-262084 DMETNA3 MI TTNWD8O DMETNA3 MN Delta-tryptase (TPSD1) DMETNA3 MT DTT DMETNA3 MA Inhibitor DMETNA3 RN Synthesis and SAR of 4-carboxy-2-azetidinone mechanism-based tryptase inhibitors. Bioorg Med Chem Lett. 2002 Nov 4;12(21):3229-33. DMETNA3 RU https://pubmed.ncbi.nlm.nih.gov/12372540 DMETNA3 DI DMETNA3 DMETNA3 DN BMS-262084 DMETNA3 MI TTM1TDX DMETNA3 MN Tryptase alpha/beta-1 (Tryptase) DMETNA3 MT DTT DMETNA3 MA Inhibitor DMETNA3 RN Synthesis and SAR of 4-carboxy-2-azetidinone mechanism-based tryptase inhibitors. Bioorg Med Chem Lett. 2002 Nov 4;12(21):3229-33. DMETNA3 RU https://pubmed.ncbi.nlm.nih.gov/12372540 DM6LPIG DI DM6LPIG DM6LPIG DN BMS-265246 DM6LPIG MI TTH6V3D DM6LPIG MN Cyclin-dependent kinase 1 (CDK1) DM6LPIG MT DTT DM6LPIG MA Inhibitor DM6LPIG RN A robust high-content imaging approach for probing the mechanism of action and phenotypic outcomes of cell-cycle modulators. Mol Cancer Ther. 2011 Feb;10(2):242-54. DM6LPIG RU https://pubmed.ncbi.nlm.nih.gov/21216932 DM6LPIG DI DM6LPIG DM6LPIG DN BMS-265246 DM6LPIG MI TT7HF4W DM6LPIG MN Cyclin-dependent kinase 2 (CDK2) DM6LPIG MT DTT DM6LPIG MA Inhibitor DM6LPIG RN A robust high-content imaging approach for probing the mechanism of action and phenotypic outcomes of cell-cycle modulators. Mol Cancer Ther. 2011 Feb;10(2):242-54. DM6LPIG RU https://pubmed.ncbi.nlm.nih.gov/21216932 DMZLE0U DI DMZLE0U DMZLE0U DN BMS-269223 DMZLE0U MI TTCIHJA DMZLE0U MN Coagulation factor Xa (F10) DMZLE0U MT DTT DMZLE0U MA Inhibitor DMZLE0U RN Aroylguanidine-based factor Xa inhibitors: the discovery of BMS-344577. Bioorg Med Chem Lett. 2009 Dec 15;19(24):6882-9. DMZLE0U RU https://pubmed.ncbi.nlm.nih.gov/19896847 DM82SJP DI DM82SJP DM82SJP DN BMS270394 DM82SJP MI TT1Q3IE DM82SJP MN Retinoic acid receptor gamma (RARG) DM82SJP MT DTT DM82SJP MA Agonist DM82SJP RN Enantiomer discrimination illustrated by high-resolution crystal structures of the human nuclear receptor hRARgamma. Proc Natl Acad Sci U S A. 2000 Jun 6;97(12):6322-7. DM82SJP RU https://pubmed.ncbi.nlm.nih.gov/10841540 DMOLCFQ DI DMOLCFQ DMOLCFQ DN BMS-279700 DMOLCFQ MI TT6PKBN DMOLCFQ MN Proto-oncogene c-Src (SRC) DMOLCFQ MT DTT DMOLCFQ MA Inhibitor DMOLCFQ RN Synthesis and c-Src inhibitory activity of imidazo[1,5-a]pyrazine derivatives as an agent for treatment of acute ischemic stroke. Bioorg Med Chem. 2007 Jan 15;15(2):868-85. DMOLCFQ RU https://pubmed.ncbi.nlm.nih.gov/17095233 DM21CYI DI DM21CYI DM21CYI DN BMS-316810 DM21CYI MI TT7WZIJ DM21CYI MN CAAX farnesyltransferase beta (FNTB) DM21CYI MT DTT DM21CYI MA Inhibitor DM21CYI RN Design, synthesis, and structure-activity relationships of tetrahydroquinoline-based farnesyltransferase inhibitors. Bioorg Med Chem Lett. 2005 Apr 1;15(7):1895-9. DM21CYI RU https://pubmed.ncbi.nlm.nih.gov/15780629 DM9WRUG DI DM9WRUG DM9WRUG DN BMS-344577 DM9WRUG MI TT6L509 DM9WRUG MN Coagulation factor IIa (F2) DM9WRUG MT DTT DM9WRUG MA Inhibitor DM9WRUG RN Aroylguanidine-based factor Xa inhibitors: the discovery of BMS-344577. Bioorg Med Chem Lett. 2009 Dec 15;19(24):6882-9. DM9WRUG RU https://pubmed.ncbi.nlm.nih.gov/19896847 DM9WRUG DI DM9WRUG DM9WRUG DN BMS-344577 DM9WRUG MI TTCIHJA DM9WRUG MN Coagulation factor Xa (F10) DM9WRUG MT DTT DM9WRUG MA Inhibitor DM9WRUG RN Aroylguanidine-based factor Xa inhibitors: the discovery of BMS-344577. Bioorg Med Chem Lett. 2009 Dec 15;19(24):6882-9. DM9WRUG RU https://pubmed.ncbi.nlm.nih.gov/19896847 DM9WRUG DI DM9WRUG DM9WRUG DN BMS-344577 DM9WRUG MI TTXAGYU DM9WRUG MN Tissue-type plasminogen activator (PLAT) DM9WRUG MT DTT DM9WRUG MA Inhibitor DM9WRUG RN Aroylguanidine-based factor Xa inhibitors: the discovery of BMS-344577. Bioorg Med Chem Lett. 2009 Dec 15;19(24):6882-9. DM9WRUG RU https://pubmed.ncbi.nlm.nih.gov/19896847 DM7D519 DI DM7D519 DM7D519 DN BMS-345541 DM7D519 MI TTRPDBG DM7D519 MN Inhibitor of nuclear factor kappa-B kinase (IKK) DM7D519 MT DTT DM7D519 MA Inhibitor DM7D519 RN A highly selective inhibitor of I kappa B kinase, BMS-345541, blocks both joint inflammation and destruction in collagen-induced arthritis in mice. Arthritis Rheum. 2003 Sep;48(9):2652-9. DM7D519 RU https://pubmed.ncbi.nlm.nih.gov/13130486 DM1ZDFG DI DM1ZDFG DM1ZDFG DN BMS-404683 DM1ZDFG MI TT7WZIJ DM1ZDFG MN CAAX farnesyltransferase beta (FNTB) DM1ZDFG MT DTT DM1ZDFG MA Inhibitor DM1ZDFG RN Protein farnesyltransferase inhibitors exhibit potent antimalarial activity. J Med Chem. 2005 Jun 2;48(11):3704-13. DM1ZDFG RU https://pubmed.ncbi.nlm.nih.gov/15916422 DM1ZDFG DI DM1ZDFG DM1ZDFG DN BMS-404683 DM1ZDFG MI TTXQKM3 DM1ZDFG MN Farnesyl protein transferase (Ftase) DM1ZDFG MT DTT DM1ZDFG MA Inhibitor DM1ZDFG RN Protein farnesyltransferase inhibitors exhibit potent antimalarial activity. J Med Chem. 2005 Jun 2;48(11):3704-13. DM1ZDFG RU https://pubmed.ncbi.nlm.nih.gov/15916422 DMTPNI4 DI DMTPNI4 DMTPNI4 DN BMS-480404 DMTPNI4 MI TTHWMFZ DMTPNI4 MN Fatty acid-binding protein 4 (FABP4) DMTPNI4 MT DTT DMTPNI4 MA Inhibitor DMTPNI4 RN NMR structure of a potent small molecule inhibitor bound to human keratinocyte fatty acid-binding protein. J Med Chem. 2006 Aug 10;49(16):5013-7. DMTPNI4 RU https://pubmed.ncbi.nlm.nih.gov/16884313 DMTPNI4 DI DMTPNI4 DMTPNI4 DN BMS-480404 DMTPNI4 MI TTNT2S6 DMTPNI4 MN Fatty acid-binding protein 5 (FABP5) DMTPNI4 MT DTT DMTPNI4 MA Inhibitor DMTPNI4 RN NMR structure of a potent small molecule inhibitor bound to human keratinocyte fatty acid-binding protein. J Med Chem. 2006 Aug 10;49(16):5013-7. DMTPNI4 RU https://pubmed.ncbi.nlm.nih.gov/16884313 DM6Y1QF DI DM6Y1QF DM6Y1QF DN BMS-488516 DM6Y1QF MI TT3C80U DM6Y1QF MN T-cell-specific kinase (ITK) DM6Y1QF MT DTT DM6Y1QF MA Inhibitor DM6Y1QF RN Treatment of depersonalization with serotonin reuptake blockers. J Clin Psychopharmacol. 1990 Jun;10(3):200-3. DM6Y1QF RU https://pubmed.ncbi.nlm.nih.gov/2115893 DMGH1LX DI DMGH1LX DMGH1LX DN BMS-509744 DMGH1LX MI TT3C80U DMGH1LX MN T-cell-specific kinase (ITK) DMGH1LX MT DTT DMGH1LX MA Inhibitor DMGH1LX RN Treatment of depersonalization with serotonin reuptake blockers. J Clin Psychopharmacol. 1990 Jun;10(3):200-3. DMGH1LX RU https://pubmed.ncbi.nlm.nih.gov/2115893 DMAY9TM DI DMAY9TM DMAY9TM DN BMS-520 DMAY9TM MI TT9JZCK DMAY9TM MN Sphingosine-1-phosphate receptor 1 (S1PR1) DMAY9TM MT DTT DMAY9TM MA Agonist DMAY9TM RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 275). DMAY9TM RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=275 DMXJB4N DI DMXJB4N DMXJB4N DN BMS-536924 DMXJB4N MI TTXV4FI DMXJB4N MN Albendazole monooxygenase (CYP3A4) DMXJB4N MT DTT DMXJB4N MA Inhibitor DMXJB4N RN Discovery and evaluation of 4-(2-(4-chloro-1H-pyrazol-1-yl)ethylamino)-3-(6-(1-(3-fluoropropyl)piperidin-4-yl)-4-methyl-1H-benzo[d]imidazol-2-yl)py... J Med Chem. 2008 Oct 9;51(19):5897-900. DMXJB4N RU https://pubmed.ncbi.nlm.nih.gov/18763755 DMXJB4N DI DMXJB4N DMXJB4N DN BMS-536924 DMXJB4N MI TT7HF4W DMXJB4N MN Cyclin-dependent kinase 2 (CDK2) DMXJB4N MT DTT DMXJB4N MA Inhibitor DMXJB4N RN Discovery of a (1H-benzoimidazol-2-yl)-1H-pyridin-2-one (BMS-536924) inhibitor of insulin-like growth factor I receptor kinase with in vivo antitum... J Med Chem. 2005 Sep 8;48(18):5639-43. DMXJB4N RU https://pubmed.ncbi.nlm.nih.gov/16134929 DMXJB4N DI DMXJB4N DMXJB4N DN BMS-536924 DMXJB4N MI TTR5TV4 DMXJB4N MN ERBB2 messenger RNA (HER2 mRNA) DMXJB4N MT DTT DMXJB4N MA Inhibitor DMXJB4N RN Discovery of a (1H-benzoimidazol-2-yl)-1H-pyridin-2-one (BMS-536924) inhibitor of insulin-like growth factor I receptor kinase with in vivo antitum... J Med Chem. 2005 Sep 8;48(18):5639-43. DMXJB4N RU https://pubmed.ncbi.nlm.nih.gov/16134929 DMXJB4N DI DMXJB4N DMXJB4N DN BMS-536924 DMXJB4N MI TT4TQBX DMXJB4N MN Extracellular signal-regulated kinase 2 (ERK2) DMXJB4N MT DTT DMXJB4N MA Inhibitor DMXJB4N RN Discovery of a (1H-benzoimidazol-2-yl)-1H-pyridin-2-one (BMS-536924) inhibitor of insulin-like growth factor I receptor kinase with in vivo antitum... J Med Chem. 2005 Sep 8;48(18):5639-43. DMXJB4N RU https://pubmed.ncbi.nlm.nih.gov/16134929 DMXJB4N DI DMXJB4N DMXJB4N DN BMS-536924 DMXJB4N MI TTON5IT DMXJB4N MN Focal adhesion kinase 1 (FAK) DMXJB4N MT DTT DMXJB4N MA Inhibitor DMXJB4N RN Discovery of a (1H-benzoimidazol-2-yl)-1H-pyridin-2-one (BMS-536924) inhibitor of insulin-like growth factor I receptor kinase with in vivo antitum... J Med Chem. 2005 Sep 8;48(18):5639-43. DMXJB4N RU https://pubmed.ncbi.nlm.nih.gov/16134929 DMXJB4N DI DMXJB4N DMXJB4N DN BMS-536924 DMXJB4N MI TTCEJ4F DMXJB4N MN G1/S-specific cyclin-E1 (CCNE1) DMXJB4N MT DTT DMXJB4N MA Inhibitor DMXJB4N RN Discovery of a (1H-benzoimidazol-2-yl)-1H-pyridin-2-one (BMS-536924) inhibitor of insulin-like growth factor I receptor kinase with in vivo antitum... J Med Chem. 2005 Sep 8;48(18):5639-43. DMXJB4N RU https://pubmed.ncbi.nlm.nih.gov/16134929 DMXJB4N DI DMXJB4N DMXJB4N DN BMS-536924 DMXJB4N MI TTHRID2 DMXJB4N MN Insulin-like growth factor I receptor (IGF1R) DMXJB4N MT DTT DMXJB4N MA Inhibitor DMXJB4N RN SAR of PXR transactivation in benzimidazole-based IGF-1R kinase inhibitors. Bioorg Med Chem Lett. 2010 Mar 1;20(5):1744-8. DMXJB4N RU https://pubmed.ncbi.nlm.nih.gov/20153189 DMXJB4N DI DMXJB4N DMXJB4N DN BMS-536924 DMXJB4N MI TT860QF DMXJB4N MN LCK tyrosine protein kinase (LCK) DMXJB4N MT DTT DMXJB4N MA Inhibitor DMXJB4N RN Discovery of a (1H-benzoimidazol-2-yl)-1H-pyridin-2-one (BMS-536924) inhibitor of insulin-like growth factor I receptor kinase with in vivo antitum... J Med Chem. 2005 Sep 8;48(18):5639-43. DMXJB4N RU https://pubmed.ncbi.nlm.nih.gov/16134929 DMXJB4N DI DMXJB4N DMXJB4N DN BMS-536924 DMXJB4N MI TT8FYO9 DMXJB4N MN Platelet-derived growth factor receptor alpha (PDGFRA) DMXJB4N MT DTT DMXJB4N MA Inhibitor DMXJB4N RN Discovery of a (1H-benzoimidazol-2-yl)-1H-pyridin-2-one (BMS-536924) inhibitor of insulin-like growth factor I receptor kinase with in vivo antitum... J Med Chem. 2005 Sep 8;48(18):5639-43. DMXJB4N RU https://pubmed.ncbi.nlm.nih.gov/16134929 DMXJB4N DI DMXJB4N DMXJB4N DN BMS-536924 DMXJB4N MI TTI7421 DMXJB4N MN Platelet-derived growth factor receptor beta (PDGFRB) DMXJB4N MT DTT DMXJB4N MA Inhibitor DMXJB4N RN Discovery of a (1H-benzoimidazol-2-yl)-1H-pyridin-2-one (BMS-536924) inhibitor of insulin-like growth factor I receptor kinase with in vivo antitum... J Med Chem. 2005 Sep 8;48(18):5639-43. DMXJB4N RU https://pubmed.ncbi.nlm.nih.gov/16134929 DMXJB4N DI DMXJB4N DMXJB4N DN BMS-536924 DMXJB4N MI TTNDSF4 DMXJB4N MN Proto-oncogene c-Met (MET) DMXJB4N MT DTT DMXJB4N MA Inhibitor DMXJB4N RN Discovery of a (1H-benzoimidazol-2-yl)-1H-pyridin-2-one (BMS-536924) inhibitor of insulin-like growth factor I receptor kinase with in vivo antitum... J Med Chem. 2005 Sep 8;48(18):5639-43. DMXJB4N RU https://pubmed.ncbi.nlm.nih.gov/16134929 DMXJB4N DI DMXJB4N DMXJB4N DN BMS-536924 DMXJB4N MI TTWTSCV DMXJB4N MN RAC-alpha serine/threonine-protein kinase (AKT1) DMXJB4N MT DTT DMXJB4N MA Inhibitor DMXJB4N RN Discovery of a (1H-benzoimidazol-2-yl)-1H-pyridin-2-one (BMS-536924) inhibitor of insulin-like growth factor I receptor kinase with in vivo antitum... J Med Chem. 2005 Sep 8;48(18):5639-43. DMXJB4N RU https://pubmed.ncbi.nlm.nih.gov/16134929 DMXJB4N DI DMXJB4N DMXJB4N DN BMS-536924 DMXJB4N MI TTUTJGQ DMXJB4N MN Vascular endothelial growth factor receptor 2 (KDR) DMXJB4N MT DTT DMXJB4N MA Inhibitor DMXJB4N RN Discovery of a (1H-benzoimidazol-2-yl)-1H-pyridin-2-one (BMS-536924) inhibitor of insulin-like growth factor I receptor kinase with in vivo antitum... J Med Chem. 2005 Sep 8;48(18):5639-43. DMXJB4N RU https://pubmed.ncbi.nlm.nih.gov/16134929 DM3WBKN DI DM3WBKN DM3WBKN DN BMS-561388 DM3WBKN MI TT7EFHR DM3WBKN MN Corticotropin-releasing factor receptor 1 (CRHR1) DM3WBKN MT DTT DM3WBKN MA Inhibitor DM3WBKN RN 8-(4-Methoxyphenyl)pyrazolo[1,5-a]-1,3,5-triazines: selective and centrally active corticotropin-releasing factor receptor-1 (CRF1) antagonists. J Med Chem. 2009 May 14;52(9):3073-83. DM3WBKN RU https://pubmed.ncbi.nlm.nih.gov/19361210 DMILMHZ DI DMILMHZ DMILMHZ DN BMS-564929 DMILMHZ MI TTKPW01 DMILMHZ MN Androgen receptor messenger RNA (AR mRNA) DMILMHZ MT DTT DMILMHZ MA Inhibitor DMILMHZ RN N-aryl-oxazolidin-2-imine muscle selective androgen receptor modulators enhance potency through pharmacophore reorientation. J Med Chem. 2009 May 14;52(9):2794-8. DMILMHZ RU https://pubmed.ncbi.nlm.nih.gov/19351168 DMZWNO9 DI DMZWNO9 DMZWNO9 DN BMS614 DMZWNO9 MI TTW38KT DMZWNO9 MN Retinoic acid receptor alpha (RARA) DMZWNO9 MT DTT DMZWNO9 MA Antagonist DMZWNO9 RN Co-regulator recruitment and the mechanism of retinoic acid receptor synergy. Nature. 2002 Jan 10;415(6868):187-92. DMZWNO9 RU https://pubmed.ncbi.nlm.nih.gov/11805839 DMRT7G3 DI DMRT7G3 DMRT7G3 DN BMS641 DMRT7G3 MI TTISP28 DMRT7G3 MN Retinoic acid receptor beta (RARB) DMRT7G3 MT DTT DMRT7G3 MA Agonist DMRT7G3 RN Rational design of RAR-selective ligands revealed by RARbeta crystal stucture. EMBO Rep. 2004 Sep;5(9):877-82. DMRT7G3 RU https://pubmed.ncbi.nlm.nih.gov/15319780 DMBTMO9 DI DMBTMO9 DMBTMO9 DN BMS-645737 DMBTMO9 MI TTUTJGQ DMBTMO9 MN Vascular endothelial growth factor receptor 2 (KDR) DMBTMO9 MT DTT DMBTMO9 MA Inhibitor DMBTMO9 RN Discovery and preclinical studies of 5-isopropyl-6-(5-methyl-1,3,4-oxadiazol-2-yl)-N-(2-methyl-1H-pyrrolo[2,3-b]pyridin-5-yl)pyrrolo[2,1-f][1,2,4]t... Bioorg Med Chem Lett. 2008 May 1;18(9):2985-9. DMBTMO9 RU https://pubmed.ncbi.nlm.nih.gov/18395443 DMBTMO9 DI DMBTMO9 DMBTMO9 DN BMS-645737 DMBTMO9 MI TTQ6VDM DMBTMO9 MN Voltage-gated potassium channel Kv11.1 (KCNH2) DMBTMO9 MT DTT DMBTMO9 MA Inhibitor DMBTMO9 RN Discovery and preclinical studies of 5-isopropyl-6-(5-methyl-1,3,4-oxadiazol-2-yl)-N-(2-methyl-1H-pyrrolo[2,3-b]pyridin-5-yl)pyrrolo[2,1-f][1,2,4]t... Bioorg Med Chem Lett. 2008 May 1;18(9):2985-9. DMBTMO9 RU https://pubmed.ncbi.nlm.nih.gov/18395443 DMYAPG5 DI DMYAPG5 DMYAPG5 DN BMS-687453 DMYAPG5 MI TTJ584C DMYAPG5 MN Peroxisome proliferator-activated receptor alpha (PPARA) DMYAPG5 MT DTT DMYAPG5 MA Inhibitor DMYAPG5 RN Discovery of an oxybenzylglycine based peroxisome proliferator activated receptor alpha selective agonist 2-((3-((2-(4-chlorophenyl)-5-methyloxazol... J Med Chem. 2010 Apr 8;53(7):2854-64. DMYAPG5 RU https://pubmed.ncbi.nlm.nih.gov/20218621 DM8PA3U DI DM8PA3U DM8PA3U DN BMS-694153 DM8PA3U MI TTY6O0Q DM8PA3U MN Calcitonin gene-related peptide receptor (CGRPR) DM8PA3U MT DTT DM8PA3U MA Inhibitor DM8PA3U RN Discovery of (R)-4-(8-fluoro-2-oxo-1,2-dihydroquinazolin-3(4H)-yl)-N-(3-(7-methyl-1H-indazol-5-yl)-1-oxo-1-(4-(piperidin-1-yl)piperidin-1-yl)propan... J Med Chem. 2008 Aug 28;51(16):4858-61. DM8PA3U RU https://pubmed.ncbi.nlm.nih.gov/18665579 DM8PA3U DI DM8PA3U DM8PA3U DN BMS-694153 DM8PA3U MI TTVG215 DM8PA3U MN Debrisoquine 4-hydroxylase (CYP2D6) DM8PA3U MT DTT DM8PA3U MA Inhibitor DM8PA3U RN Discovery of (R)-4-(8-fluoro-2-oxo-1,2-dihydroquinazolin-3(4H)-yl)-N-(3-(7-methyl-1H-indazol-5-yl)-1-oxo-1-(4-(piperidin-1-yl)piperidin-1-yl)propan... J Med Chem. 2008 Aug 28;51(16):4858-61. DM8PA3U RU https://pubmed.ncbi.nlm.nih.gov/18665579 DMFODQV DI DMFODQV DMFODQV DN BMS-739562 DMFODQV MI TTLYXIT DMFODQV MN Aurora kinase C (AURKC) DMFODQV MT DTT DMFODQV MA Inhibitor DMFODQV RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1936). DMFODQV RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1936 DMQ24TI DI DMQ24TI DMQ24TI DN BMS-740808 DMQ24TI MI TT6L509 DMQ24TI MN Coagulation factor IIa (F2) DMQ24TI MT DTT DMQ24TI MA Inhibitor DMQ24TI RN Structure-activity relationship and pharmacokinetic profile of 5-ketopyrazole factor Xa inhibitors. Bioorg Med Chem Lett. 2008 Jan 15;18(2):749-54. DMQ24TI RU https://pubmed.ncbi.nlm.nih.gov/18054227 DMQ24TI DI DMQ24TI DMQ24TI DN BMS-740808 DMQ24TI MI TTCIHJA DMQ24TI MN Coagulation factor Xa (F10) DMQ24TI MT DTT DMQ24TI MA Inhibitor DMQ24TI RN Discovery of 1-(4-methoxyphenyl)-7-oxo-6-(4-(2-oxopiperidin-1-yl)phenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxamide (apixaban, BMS... J Med Chem. 2007 Nov 1;50(22):5339-56. DMQ24TI RU https://pubmed.ncbi.nlm.nih.gov/17914785 DMSX1NF DI DMSX1NF DMSX1NF DN BMS753 DMSX1NF MI TTW38KT DMSX1NF MN Retinoic acid receptor alpha (RARA) DMSX1NF MT DTT DMSX1NF MA Agonist DMSX1NF RN Structural basis for engineering of retinoic acid receptor isotype-selective agonists and antagonists. Chem Biol. 1999 Aug;6(8):519-29. DMSX1NF RU https://pubmed.ncbi.nlm.nih.gov/10421757 DM1HBF5 DI DM1HBF5 DM1HBF5 DN BMS-812204 DM1HBF5 MI TT6OEDT DM1HBF5 MN Cannabinoid receptor 1 (CB1) DM1HBF5 MT DTT DM1HBF5 MA Antagonist DM1HBF5 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 56). DM1HBF5 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=56 DMI796T DI DMI796T DMI796T DN BMS-A DMI796T MI TTFZYTO DMI796T MN C-C chemokine receptor type 2 (CCR2) DMI796T MT DTT DMI796T MA Antagonist DMI796T RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 59). DMI796T RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=59 DMT02B8 DI DMT02B8 DMT02B8 DN BMY 45778 DMT02B8 MI TTOFYT1 DMT02B8 MN Prostacyclin receptor (PTGIR) DMT02B8 MT DTT DMT02B8 MA Agonist DMT02B8 RN Relaxant actions of nonprostanoid prostacyclin mimetics on human pulmonary artery. J Cardiovasc Pharmacol. 1997 Apr;29(4):525-35. DMT02B8 RU https://pubmed.ncbi.nlm.nih.gov/9156364 DMAMYWL DI DMAMYWL DMAMYWL DN BMY-27709 DMAMYWL MI TTF4CAM DMAMYWL MN Influenza Hemagglutinin (Influ HA) DMAMYWL MT DTT DMAMYWL MA Inhibitor DMAMYWL RN Structure of influenza hemagglutinin in complex with an inhibitor of membrane fusion. Proc Natl Acad Sci U S A. 2008 Nov 18;105(46):17736-41. DMAMYWL RU https://pubmed.ncbi.nlm.nih.gov/19004788 DM1CNU5 DI DM1CNU5 DM1CNU5 DN BN-81,644 DM1CNU5 MI TTJX3UE DM1CNU5 MN Somatostatin receptor type 3 (SSTR3) DM1CNU5 MT DTT DM1CNU5 MA Agonist DM1CNU5 RN Identification of potent non-peptide somatostatin antagonists with sst(3) selectivity. J Med Chem. 2001 Aug 30;44(18):2990-3000. DM1CNU5 RU https://pubmed.ncbi.nlm.nih.gov/11520208 DM7RPQ4 DI DM7RPQ4 DM7RPQ4 DN BN-81,674 DM7RPQ4 MI TTJX3UE DM7RPQ4 MN Somatostatin receptor type 3 (SSTR3) DM7RPQ4 MT DTT DM7RPQ4 MA Agonist DM7RPQ4 RN Identification of potent non-peptide somatostatin antagonists with sst(3) selectivity. J Med Chem. 2001 Aug 30;44(18):2990-3000. DM7RPQ4 RU https://pubmed.ncbi.nlm.nih.gov/11520208 DMXY574 DI DMXY574 DMXY574 DN BN-82002 DMXY574 MI TTESBNC DMXY574 MN M-phase inducer phosphatase 3 (MPIP3) DMXY574 MT DTT DMXY574 MA Inhibitor DMXY574 RN Synthesis of small molecule CDC25 phosphatases inhibitors. Bioorg Med Chem Lett. 2004 Dec 6;14(23):5809-12. DMXY574 RU https://pubmed.ncbi.nlm.nih.gov/15501045 DMZME4N DI DMZME4N DMZME4N DN BN-82685 DMZME4N MI TTESBNC DMZME4N MN M-phase inducer phosphatase 3 (MPIP3) DMZME4N MT DTT DMZME4N MA Inhibitor DMZME4N RN Synthesis and biological evaluation of novel heterocyclic quinones as inhibitors of the dual specificity protein phosphatase CDC25C. Bioorg Med Chem Lett. 2006 Jan 1;16(1):171-5. DMZME4N RU https://pubmed.ncbi.nlm.nih.gov/16216500 DMJI1EA DI DMJI1EA DMJI1EA DN BND-001 DMJI1EA MI TTNT7K8 DMJI1EA MN Nociceptin receptor (OPRL1) DMJI1EA MT DTT DMJI1EA MA Antagonist DMJI1EA RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 320). DMJI1EA RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=320 DM48VJR DI DM48VJR DM48VJR DN B-Nonylglucoside DM48VJR MI TTXMY0J DM48VJR MN Pancreatic triacylglycerol lipase (PNLIP) DM48VJR MT DTT DM48VJR MA Inhibitor DM48VJR RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DM48VJR RU https://pubmed.ncbi.nlm.nih.gov/10592235 DM48VJR DI DM48VJR DM48VJR DN B-Nonylglucoside DM48VJR MI TTH0KSX DM48VJR MN Rhodopsin (RHO) DM48VJR MT DTT DM48VJR MA Inhibitor DM48VJR RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DM48VJR RU https://pubmed.ncbi.nlm.nih.gov/10592235 DMJY1KR DI DMJY1KR DMJY1KR DN BNP-FIX DMJY1KR MI TTFEZ5Q DMJY1KR MN Coagulation factor IX (F9) DMJY1KR MT DTT DMJY1KR MA Modulator DMJY1KR RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2364). DMJY1KR RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2364 DMIOHMZ DI DMIOHMZ DMIOHMZ DN BNV-222 DMIOHMZ MI TTFBNVI DMIOHMZ MN Aldose reductase (AKR1B1) DMIOHMZ MT DTT DMIOHMZ MA Modulator DMIOHMZ RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2768). DMIOHMZ RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2768 DMCUJH5 DI DMCUJH5 DMCUJH5 DN Bo(15)PZ DMCUJH5 MI TTZ9SOR DMCUJH5 MN Muscarinic acetylcholine receptor M1 (CHRM1) DMCUJH5 MT DTT DMCUJH5 MA Inhibitor DMCUJH5 RN On the use of nonfluorescent dye labeled ligands in FRET-based receptor binding studies. J Med Chem. 2005 Dec 1;48(24):7847-59. DMCUJH5 RU https://pubmed.ncbi.nlm.nih.gov/16302823 DMDX8M3 DI DMDX8M3 DMDX8M3 DN Boc-Agly-Val-Agly-OEt DMDX8M3 MI TTDZN01 DMDX8M3 MN Cathepsin K (CTSK) DMDX8M3 MT DTT DMDX8M3 MA Inhibitor DMDX8M3 RN Azapeptides structurally based upon inhibitory sites of cystatins as potent and selective inhibitors of cysteine proteases. J Med Chem. 2002 Sep 12;45(19):4202-11. DMDX8M3 RU https://pubmed.ncbi.nlm.nih.gov/12213061 DMPJR98 DI DMPJR98 DMPJR98 DN Boc-Asp-Tyr(So3-)-Nle-Gly-Trp-Asp-Phe-NH2 DMPJR98 MI TTCG0AL DMPJR98 MN Cholecystokinin receptor type A (CCKAR) DMPJR98 MT DTT DMPJR98 MA Inhibitor DMPJR98 RN Synthesis and biological activities of pseudopeptide analogues of the C-terminal heptapeptide of cholecystokinin. On the importance of the peptide ... J Med Chem. 1987 Aug;30(8):1366-73. DMPJR98 RU https://pubmed.ncbi.nlm.nih.gov/2441054 DMPJR98 DI DMPJR98 DMPJR98 DN Boc-Asp-Tyr(So3-)-Nle-Gly-Trp-Asp-Phe-NH2 DMPJR98 MI TTVFO0U DMPJR98 MN Gastrin/cholecystokinin type B receptor (CCKBR) DMPJR98 MT DTT DMPJR98 MA Inhibitor DMPJR98 RN Synthesis and biological activities of pseudopeptide analogues of the C-terminal heptapeptide of cholecystokinin. On the importance of the peptide ... J Med Chem. 1987 Aug;30(8):1366-73. DMPJR98 RU https://pubmed.ncbi.nlm.nih.gov/2441054 DMRQVME DI DMRQVME DMRQVME DN Boc-cyclo-(Glu-Tyr-Nle-D-Lys)-Trp-Nle-Asp-Phe-NH2 DMRQVME MI TTCG0AL DMRQVME MN Cholecystokinin receptor type A (CCKAR) DMRQVME MT DTT DMRQVME MA Inhibitor DMRQVME RN Synthesis and binding affinities of cyclic and related linear analogues of CCK8 selective for central receptors. J Med Chem. 1989 Jun;32(6):1184-90. DMRQVME RU https://pubmed.ncbi.nlm.nih.gov/2724293 DMBCPKF DI DMBCPKF DMBCPKF DN Boc-D-Glu-Tyr(SO3H)-Nle-D-Lys-Trp-Nle-Asp-Phe-NH2 DMBCPKF MI TTCG0AL DMBCPKF MN Cholecystokinin receptor type A (CCKAR) DMBCPKF MT DTT DMBCPKF MA Inhibitor DMBCPKF RN Synthesis and binding affinities of cyclic and related linear analogues of CCK8 selective for central receptors. J Med Chem. 1989 Jun;32(6):1184-90. DMBCPKF RU https://pubmed.ncbi.nlm.nih.gov/2724293 DM1IXOG DI DM1IXOG DM1IXOG DN Boc-D-Glu-Tyr(SO3H)-Nle-D-Nle-Trp-Nle-Asp-Phe-NH2 DM1IXOG MI TTCG0AL DM1IXOG MN Cholecystokinin receptor type A (CCKAR) DM1IXOG MT DTT DM1IXOG MA Inhibitor DM1IXOG RN Synthesis and binding affinities of cyclic and related linear analogues of CCK8 selective for central receptors. J Med Chem. 1989 Jun;32(6):1184-90. DM1IXOG RU https://pubmed.ncbi.nlm.nih.gov/2724293 DMFWJC2 DI DMFWJC2 DMFWJC2 DN Boceprevir DMFWJC2 MI TT1D53B DMFWJC2 MN COVID-19 3C-like protease (3CLpro) DMFWJC2 MT DTT DMFWJC2 MA Inhibitor DMFWJC2 RN Boceprevir, GC-376, and calpain inhibitors II, XII inhibit SARS-CoV-2 viral replication by targeting the viral main protease. 2020. April 20. doi: https://doi.org/10.1101/2020.04.20.051581 DMFWJC2 RU https://www.biorxiv.org/content/10.1101/2020.04.20.051581v1 DMN3EU9 DI DMN3EU9 DMN3EU9 DN Boc-Glu-Tyr(SO3H)-Nle-D-Lys-Trp-Nle-Asp-Phe-NH2 DMN3EU9 MI TTCG0AL DMN3EU9 MN Cholecystokinin receptor type A (CCKAR) DMN3EU9 MT DTT DMN3EU9 MA Inhibitor DMN3EU9 RN Synthesis and binding affinities of cyclic and related linear analogues of CCK8 selective for central receptors. J Med Chem. 1989 Jun;32(6):1184-90. DMN3EU9 RU https://pubmed.ncbi.nlm.nih.gov/2724293 DMG35MJ DI DMG35MJ DMG35MJ DN Boc-Ile-Leu-L-(difluoro)aminobutyric aid DMG35MJ MI TTWXB3E DMG35MJ MN Hepatitis C virus NS3 helicase (HCV NS3) DMG35MJ MT DTT DMG35MJ MA Inhibitor DMG35MJ RN Control of hepatitis C: a medicinal chemistry perspective. J Med Chem. 2005 Jan 13;48(1):1-20. DMG35MJ RU https://pubmed.ncbi.nlm.nih.gov/15633995 DMMO75G DI DMMO75G DMMO75G DN B-Octylglucoside DMMO75G MI TTGQA9W DMMO75G MN Apolipoprotein A-II (APOA2) DMMO75G MT DTT DMMO75G MA Inhibitor DMMO75G RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMMO75G RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMMO75G DI DMMO75G DMMO75G DN B-Octylglucoside DMMO75G MI TTKYZA9 DMMO75G MN Gastric triacylglycerol lipase (LIPF) DMMO75G MT DTT DMMO75G MA Inhibitor DMMO75G RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMMO75G RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMMO75G DI DMMO75G DMMO75G DN B-Octylglucoside DMMO75G MI TTYRL6O DMMO75G MN Glucocorticoid receptor (NR3C1) DMMO75G MT DTT DMMO75G MA Inhibitor DMMO75G RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMMO75G RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMMO75G DI DMMO75G DMMO75G DN B-Octylglucoside DMMO75G MI TTO8QRU DMMO75G MN Group IIA phospholipase A2 (GIIA sPLA2) DMMO75G MT DTT DMMO75G MA Inhibitor DMMO75G RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMMO75G RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMMO75G DI DMMO75G DMMO75G DN B-Octylglucoside DMMO75G MI TTXT3PU DMMO75G MN Influenza M2 protein (Influ M) DMMO75G MT DTT DMMO75G MA Inhibitor DMMO75G RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMMO75G RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMMO75G DI DMMO75G DMMO75G DN B-Octylglucoside DMMO75G MI TT7O8ZA DMMO75G MN Lanosterol synthase (LSS) DMMO75G MT DTT DMMO75G MA Inhibitor DMMO75G RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMMO75G RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMMO75G DI DMMO75G DMMO75G DN B-Octylglucoside DMMO75G MI TT26PHO DMMO75G MN Mineralocorticoid receptor (MR) DMMO75G MT DTT DMMO75G MA Inhibitor DMMO75G RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMMO75G RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMMO75G DI DMMO75G DMMO75G DN B-Octylglucoside DMMO75G MI TTF10I9 DMMO75G MN Nitric-oxide synthase inducible (NOS2) DMMO75G MT DTT DMMO75G MA Inhibitor DMMO75G RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMMO75G RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMMO75G DI DMMO75G DMMO75G DN B-Octylglucoside DMMO75G MI TTXMY0J DMMO75G MN Pancreatic triacylglycerol lipase (PNLIP) DMMO75G MT DTT DMMO75G MA Inhibitor DMMO75G RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMMO75G RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMMO75G DI DMMO75G DMMO75G DN B-Octylglucoside DMMO75G MI TTRAMF0 DMMO75G MN Plasmodium Cytochrome B (Malaria MT-CYB) DMMO75G MT DTT DMMO75G MA Inhibitor DMMO75G RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMMO75G RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMMO75G DI DMMO75G DMMO75G DN B-Octylglucoside DMMO75G MI TT3PQ2Y DMMO75G MN Plasmodium Dihydroorotate dehydrogenase (Malaria DHOdehase) DMMO75G MT DTT DMMO75G MA Inhibitor DMMO75G RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMMO75G RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMMO75G DI DMMO75G DMMO75G DN B-Octylglucoside DMMO75G MI TT8NGED DMMO75G MN Prostaglandin G/H synthase 1 (COX-1) DMMO75G MT DTT DMMO75G MA Inhibitor DMMO75G RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMMO75G RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMMO75G DI DMMO75G DMMO75G DN B-Octylglucoside DMMO75G MI TTVKILB DMMO75G MN Prostaglandin G/H synthase 2 (COX-2) DMMO75G MT DTT DMMO75G MA Inhibitor DMMO75G RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMMO75G RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMMO75G DI DMMO75G DMMO75G DN B-Octylglucoside DMMO75G MI TTELIN2 DMMO75G MN PTPN1 messenger RNA (PTPN1 mRNA) DMMO75G MT DTT DMMO75G MA Inhibitor DMMO75G RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMMO75G RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMMO75G DI DMMO75G DMMO75G DN B-Octylglucoside DMMO75G MI TTH0KSX DMMO75G MN Rhodopsin (RHO) DMMO75G MT DTT DMMO75G MA Inhibitor DMMO75G RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMMO75G RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMMO75G DI DMMO75G DMMO75G DN B-Octylglucoside DMMO75G MI TTHM0R1 DMMO75G MN Steryl-sulfatase (STS) DMMO75G MT DTT DMMO75G MA Inhibitor DMMO75G RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMMO75G RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMMO75G DI DMMO75G DMMO75G DN B-Octylglucoside DMMO75G MI TTQBR95 DMMO75G MN Stress-activated protein kinase 2a (p38 alpha) DMMO75G MT DTT DMMO75G MA Inhibitor DMMO75G RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMMO75G RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMAYWTI DI DMAYWTI DMAYWTI DN Boc-Tyr(SO3H)-Nle-Gly-Trp-Nle-Asp-Phe-NH2 DMAYWTI MI TTCG0AL DMAYWTI MN Cholecystokinin receptor type A (CCKAR) DMAYWTI MT DTT DMAYWTI MA Inhibitor DMAYWTI RN Synthesis and binding affinities of cyclic and related linear analogues of CCK8 selective for central receptors. J Med Chem. 1989 Jun;32(6):1184-90. DMAYWTI RU https://pubmed.ncbi.nlm.nih.gov/2724293 DMY7CN3 DI DMY7CN3 DMY7CN3 DN BODIPY-pirenzepine DMY7CN3 MI TTOXS3C DMY7CN3 MN Muscarinic acetylcholine receptor (CHRM) DMY7CN3 MT DTT DMY7CN3 MA Antagonist DMY7CN3 RN Pirenzepine promotes the dimerization of muscarinic M1 receptors through a three-step binding process. J Biol Chem. 2009 Jul 17;284(29):19533-43. DMY7CN3 RU https://pubmed.ncbi.nlm.nih.gov/19451648 DMLCMA3 DI DMLCMA3 DMLCMA3 DN BOHEMINE DMLCMA3 MI TT7HF4W DMLCMA3 MN Cyclin-dependent kinase 2 (CDK2) DMLCMA3 MT DTT DMLCMA3 MA Inhibitor DMLCMA3 RN Docking-based development of purine-like inhibitors of cyclin-dependent kinase-2. J Med Chem. 2000 Jun 29;43(13):2506-13. DMLCMA3 RU https://pubmed.ncbi.nlm.nih.gov/10891109 DM0EKO5 DI DM0EKO5 DM0EKO5 DN Boldenone DM0EKO5 MI TTS64P2 DM0EKO5 MN Androgen receptor (AR) DM0EKO5 MT DTT DM0EKO5 MA Agonist DM0EKO5 RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DM0EKO5 RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMMVB5P DI DMMVB5P DMMVB5P DN BOLDINE DMMVB5P MI TTZFYLI DMMVB5P MN Dopamine D1 receptor (D1R) DMMVB5P MT DTT DMMVB5P MA Inhibitor DMMVB5P RN Halogenated boldine derivatives with enhanced monoamine receptor selectivity. J Nat Prod. 2000 Apr;63(4):480-4. DMMVB5P RU https://pubmed.ncbi.nlm.nih.gov/10785418 DMMVB5P DI DMMVB5P DMMVB5P DN BOLDINE DMMVB5P MI TTEX248 DMMVB5P MN Dopamine D2 receptor (D2R) DMMVB5P MT DTT DMMVB5P MA Inhibitor DMMVB5P RN Halogenated boldine derivatives with enhanced monoamine receptor selectivity. J Nat Prod. 2000 Apr;63(4):480-4. DMMVB5P RU https://pubmed.ncbi.nlm.nih.gov/10785418 DMMVB5P DI DMMVB5P DMMVB5P DN BOLDINE DMMVB5P MI TT4H1MQ DMMVB5P MN Neuronal acetylcholine receptor alpha-4 (CHRNA4) DMMVB5P MT DTT DMMVB5P MA Inhibitor DMMVB5P RN Aporphine metho salts as neuronal nicotinic acetylcholine receptor blockers. Bioorg Med Chem. 2007 May 15;15(10):3368-72. DMMVB5P RU https://pubmed.ncbi.nlm.nih.gov/17391965 DMMVB5P DI DMMVB5P DMMVB5P DN BOLDINE DMMVB5P MI TT5KPZR DMMVB5P MN Neuronal acetylcholine receptor beta-2 (CHRNB2) DMMVB5P MT DTT DMMVB5P MA Inhibitor DMMVB5P RN Aporphine metho salts as neuronal nicotinic acetylcholine receptor blockers. Bioorg Med Chem. 2007 May 15;15(10):3368-72. DMMVB5P RU https://pubmed.ncbi.nlm.nih.gov/17391965 DMVB6UG DI DMVB6UG DMVB6UG DN BOLINAQUINONE DMVB6UG MI TTO8QRU DMVB6UG MN Group IIA phospholipase A2 (GIIA sPLA2) DMVB6UG MT DTT DMVB6UG MA Inhibitor DMVB6UG RN New sesquiterpene derivatives from the sponge Dysidea species with a selective inhibitor profile against human phospholipase A2 and other leukocyte... J Nat Prod. 2001 May;64(5):612-5. DMVB6UG RU https://pubmed.ncbi.nlm.nih.gov/11374954 DMVB6UG DI DMVB6UG DMVB6UG DN BOLINAQUINONE DMVB6UG MI TT9V5JH DMVB6UG MN Phospholipase A2 (PLA2G1B) DMVB6UG MT DTT DMVB6UG MA Inhibitor DMVB6UG RN New sesquiterpene derivatives from the sponge Dysidea species with a selective inhibitor profile against human phospholipase A2 and other leukocyte... J Nat Prod. 2001 May;64(5):612-5. DMVB6UG RU https://pubmed.ncbi.nlm.nih.gov/11374954 DMAW40Y DI DMAW40Y DMAW40Y DN BOMA DMAW40Y MI TTHS256 DMAW40Y MN Metabotropic glutamate receptor 5 (mGluR5) DMAW40Y MT DTT DMAW40Y MA Modulator (allosteric modulator) DMAW40Y RN Discovery of novel modulators of metabotropic glutamate receptor subtype-5. Bioorg Med Chem. 2004 Jan 2;12(1):17-21. DMAW40Y RU https://pubmed.ncbi.nlm.nih.gov/14697765 DMDFQ0Y DI DMDFQ0Y DMDFQ0Y DN bombesin DMDFQ0Y MI TTHYDUM DMDFQ0Y MN Bombesin receptor (BS) DMDFQ0Y MT DTT DMDFQ0Y MA Agonist DMDFQ0Y RN Expression and characterization of cloned human bombesin receptors. Mol Pharmacol. 1995 Jan;47(1):10-20. DMDFQ0Y RU https://pubmed.ncbi.nlm.nih.gov/7838118 DMDFQ0Y DI DMDFQ0Y DMDFQ0Y DN bombesin DMDFQ0Y MI TTC1MVT DMDFQ0Y MN Gastrin-releasing peptide receptor (GRPR) DMDFQ0Y MT DTT DMDFQ0Y MA Agonist DMDFQ0Y RN Expression and characterization of cloned human bombesin receptors. Mol Pharmacol. 1995 Jan;47(1):10-20. DMDFQ0Y RU https://pubmed.ncbi.nlm.nih.gov/7838118 DMI75A3 DI DMI75A3 DMI75A3 DN BOMPPA DMI75A3 MI TT0WAIE DMI75A3 MN Melatonin receptor type 1A (MTNR1A) DMI75A3 MT DTT DMI75A3 MA Agonist DMI75A3 RN Development of substituted N-[3-(3-methoxylphenyl)propyl] amides as MT(2)-selective melatonin agonists: improving metabolic stability. Bioorg Med Chem. 2013 Jan 15;21(2):547-52. DMI75A3 RU https://pubmed.ncbi.nlm.nih.gov/23228808 DMWALXQ DI DMWALXQ DMWALXQ DN bongkrek acid DMWALXQ MI TTU5A6Q DMWALXQ MN Adenine nucleotide translocator 1 (SLC25A4) DMWALXQ MT DTT DMWALXQ MA Inhibitor DMWALXQ RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1062). DMWALXQ RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1062 DMWBV1P DI DMWBV1P DMWBV1P DN borneol DMWBV1P MI TT946IA DMWBV1P MN Transient receptor potential cation channel V3 (TRPV3) DMWBV1P MT DTT DMWBV1P MA Activator DMWBV1P RN Monoterpenoid agonists of TRPV3. Br J Pharmacol. 2007 Jun;151(4):530-40. DMWBV1P RU https://pubmed.ncbi.nlm.nih.gov/17420775 DMR70ZO DI DMR70ZO DMR70ZO DN Bornyl (3,4,5-trihydroxy)-cinnamate DMR70ZO MI TTPLTSQ DMR70ZO MN Neutrophil elastase (NE) DMR70ZO MT DTT DMR70ZO MA Inhibitor DMR70ZO RN Bornyl (3,4,5-trihydroxy)-cinnamate--an optimized human neutrophil elastase inhibitor designed by free energy calculations. Bioorg Med Chem. 2008 Mar 1;16(5):2385-90. DMR70ZO RU https://pubmed.ncbi.nlm.nih.gov/18078761 DMBSQTR DI DMBSQTR DMBSQTR DN Borrelidin DMBSQTR MI TT75YK4 DMBSQTR MN Saccharomyces Cell division control protein 28 (Saccha CDC28) DMBSQTR MT DTT DMBSQTR MA Inhibitor DMBSQTR RN Borrelidin inhibits a cyclin-dependent kinase (CDK), Cdc28/Cln2, of Saccharomyces cerevisiae. J Antibiot (Tokyo). 2001 Jan;54(1):84-90. DMBSQTR RU https://pubmed.ncbi.nlm.nih.gov/11269718 DMRELJ0 DI DMRELJ0 DMRELJ0 DN Bovinic acid DMRELJ0 MI DEVYB4R DMRELJ0 MN Linoleic acid reductase (cla-r) DMRELJ0 MT DME DMRELJ0 MA Metabolism DMRELJ0 RN Effect of linoleic acid concentration on conjugated linoleic acid production by Butyrivibrio fibrisolvens A38. Appl Environ Microbiol. 2000 Dec;66(12):5226-30. DMRELJ0 RU https://pubmed.ncbi.nlm.nih.gov/11097894 DMGEYFB DI DMGEYFB DMGEYFB DN BP-100-1.02 DMGEYFB MI TTFOUV4 DMGEYFB MN BCL-2 messenger RNA (BCL2 mRNA) DMGEYFB MT DTT DMGEYFB RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2844). DMGEYFB RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2844 DMUOS3G DI DMUOS3G DMUOS3G DN BPH-252 DMUOS3G MI TTIKWV4 DMUOS3G MN Geranyltranstransferase (FDPS) DMUOS3G MT DTT DMUOS3G MA Inhibitor DMUOS3G RN Inhibition of geranylgeranyl diphosphate synthase by bisphosphonates: a crystallographic and computational investigation. J Med Chem. 2008 Sep 25;51(18):5594-607. DMUOS3G RU https://pubmed.ncbi.nlm.nih.gov/18800762 DM0NQLI DI DM0NQLI DM0NQLI DN BPH-608 DM0NQLI MI TTIKWV4 DM0NQLI MN Geranyltranstransferase (FDPS) DM0NQLI MT DTT DM0NQLI MA Inhibitor DM0NQLI RN Bisphosphonates target multiple sites in both cis- and trans-prenyltransferases. Proc Natl Acad Sci U S A. 2007 Jun 12;104(24):10022-7. DM0NQLI RU https://pubmed.ncbi.nlm.nih.gov/17535895 DM0TJ6R DI DM0TJ6R DM0TJ6R DN BPH-628 DM0TJ6R MI TTIKWV4 DM0TJ6R MN Geranyltranstransferase (FDPS) DM0TJ6R MT DTT DM0TJ6R MA Inhibitor DM0TJ6R RN Inhibition of geranylgeranyl diphosphate synthase by bisphosphonates: a crystallographic and computational investigation. J Med Chem. 2008 Sep 25;51(18):5594-607. DM0TJ6R RU https://pubmed.ncbi.nlm.nih.gov/18800762 DM49BFM DI DM49BFM DM49BFM DN BPH-629 DM49BFM MI TTIKWV4 DM49BFM MN Geranyltranstransferase (FDPS) DM49BFM MT DTT DM49BFM MA Inhibitor DM49BFM RN Bisphosphonates target multiple sites in both cis- and trans-prenyltransferases. Proc Natl Acad Sci U S A. 2007 Jun 12;104(24):10022-7. DM49BFM RU https://pubmed.ncbi.nlm.nih.gov/17535895 DMX4WI7 DI DMX4WI7 DMX4WI7 DN BPH-652 DMX4WI7 MI TTFQEO5 DMX4WI7 MN Squalene synthetase (FDFT1) DMX4WI7 MT DTT DMX4WI7 MA Inhibitor DMX4WI7 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 645). DMX4WI7 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=645 DM3IPYV DI DM3IPYV DM3IPYV DN BPH-675 DM3IPYV MI TTIKWV4 DM3IPYV MN Geranyltranstransferase (FDPS) DM3IPYV MT DTT DM3IPYV MA Inhibitor DM3IPYV RN Bisphosphonates target multiple sites in both cis- and trans-prenyltransferases. Proc Natl Acad Sci U S A. 2007 Jun 12;104(24):10022-7. DM3IPYV RU https://pubmed.ncbi.nlm.nih.gov/17535895 DMPKAEW DI DMPKAEW DMPKAEW DN BPH-676 DMPKAEW MI TTIKWV4 DMPKAEW MN Geranyltranstransferase (FDPS) DMPKAEW MT DTT DMPKAEW MA Inhibitor DMPKAEW RN Bisphosphonates target multiple sites in both cis- and trans-prenyltransferases. Proc Natl Acad Sci U S A. 2007 Jun 12;104(24):10022-7. DMPKAEW RU https://pubmed.ncbi.nlm.nih.gov/17535895 DMTHW3F DI DMTHW3F DMTHW3F DN BPH-715 DMTHW3F MI TTIKWV4 DMTHW3F MN Geranyltranstransferase (FDPS) DMTHW3F MT DTT DMTHW3F MA Inhibitor DMTHW3F RN Inhibition of geranylgeranyl diphosphate synthase by bisphosphonates: a crystallographic and computational investigation. J Med Chem. 2008 Sep 25;51(18):5594-607. DMTHW3F RU https://pubmed.ncbi.nlm.nih.gov/18800762 DMD0XEO DI DMD0XEO DMD0XEO DN BPH-742 DMD0XEO MI TTIKWV4 DMD0XEO MN Geranyltranstransferase (FDPS) DMD0XEO MT DTT DMD0XEO MA Inhibitor DMD0XEO RN Inhibition of geranylgeranyl diphosphate synthase by bisphosphonates: a crystallographic and computational investigation. J Med Chem. 2008 Sep 25;51(18):5594-607. DMD0XEO RU https://pubmed.ncbi.nlm.nih.gov/18800762 DM15L2J DI DM15L2J DM15L2J DN BPH-830 DM15L2J MI TTFQEO5 DM15L2J MN Squalene synthetase (FDFT1) DM15L2J MT DTT DM15L2J MA Inhibitor DM15L2J RN Inhibition of staphyloxanthin virulence factor biosynthesis in Staphylococcus aureus: in vitro, in vivo, and crystallographic results. J Med Chem. 2009 Jul 9;52(13):3869-80. DM15L2J RU https://pubmed.ncbi.nlm.nih.gov/19456099 DMGQXTR DI DMGQXTR DMGQXTR DN BPI-704001 DMGQXTR MI TTVDSZ0 DMGQXTR MN Poly [ADP-ribose] polymerase 1 (PARP1) DMGQXTR MT DTT DMGQXTR MA Inhibitor DMGQXTR RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2771). DMGQXTR RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2771 DMOSG0Q DI DMOSG0Q DMOSG0Q DN BPI-711001 DMOSG0Q MI TTDIGC1 DMOSG0Q MN Dipeptidyl peptidase 4 (DPP-4) DMOSG0Q MT DTT DMOSG0Q MA Inhibitor DMOSG0Q RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1612). DMOSG0Q RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1612 DMNHEUT DI DMNHEUT DMNHEUT DN BPIQ-I DMNHEUT MI TTGKNB4 DMNHEUT MN Epidermal growth factor receptor (EGFR) DMNHEUT MT DTT DMNHEUT MA Inhibitor DMNHEUT RN Tyrosine kinase inhibitors. 9. Synthesis and evaluation of fused tricyclic quinazoline analogues as ATP site inhibitors of the tyrosine kinase acti... J Med Chem. 1996 Feb 16;39(4):918-28. DMNHEUT RU https://pubmed.ncbi.nlm.nih.gov/8632415 DM5OHIY DI DM5OHIY DM5OHIY DN BPKDi DM5OHIY MI TTSLUMT DM5OHIY MN Protein kinase D (PRKD1) DM5OHIY MT DTT DM5OHIY MA Inhibitor DM5OHIY RN Protein kinase D as a potential new target for cancer therapy. Biochim Biophys Acta. 2010 Dec;1806(2):183-92. DM5OHIY RU https://pubmed.ncbi.nlm.nih.gov/20580776 DMKX6LY DI DMKX6LY DMKX6LY DN BPL-001 DMKX6LY MI TTPADOQ DMKX6LY MN HMG-CoA reductase (HMGCR) DMKX6LY MT DTT DMKX6LY MA Inhibitor DMKX6LY RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 639). DMKX6LY RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=639 DMJPN8Z DI DMJPN8Z DMJPN8Z DN BPR1K-0224 DMJPN8Z MI TTLYXIT DMJPN8Z MN Aurora kinase C (AURKC) DMJPN8Z MT DTT DMJPN8Z MA Inhibitor DMJPN8Z RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1936). DMJPN8Z RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1936 DMQBRSM DI DMQBRSM DMQBRSM DN BQ 3020 DMQBRSM MI TT3ZTGU DMQBRSM MN Endothelin B receptor (EDNRB) DMQBRSM MT DTT DMQBRSM MA Agonist DMQBRSM RN Pharmacological differences between rat and human endothelin B receptors. Biochem Biophys Res Commun. 1995 Apr 17;209(2):506-12. DMQBRSM RU https://pubmed.ncbi.nlm.nih.gov/7733918 DMSGIXK DI DMSGIXK DMSGIXK DN BQCA DMSGIXK MI TTZ9SOR DMSGIXK MN Muscarinic acetylcholine receptor M1 (CHRM1) DMSGIXK MT DTT DMSGIXK MA Agonist DMSGIXK RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5436). DMSGIXK RU http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=5436 DMBTC23 DI DMBTC23 DMBTC23 DN Br-5MPEPy DMBTC23 MI TTHS256 DMBTC23 MN Metabotropic glutamate receptor 5 (mGluR5) DMBTC23 MT DTT DMBTC23 MA Modulator (allosteric modulator) DMBTC23 RN A close structural analog of 2-methyl-6-(phenylethynyl)-pyridine acts as a neutral allosteric site ligand on metabotropic glutamate receptor subtyp... Mol Pharmacol. 2005 Dec;68(6):1793-802. DMBTC23 RU https://pubmed.ncbi.nlm.nih.gov/16155210 DM0DWSR DI DM0DWSR DM0DWSR DN bradyzide DM0DWSR MI TTGY8IW DM0DWSR MN B2 bradykinin receptor (BDKRB2) DM0DWSR MT DTT DM0DWSR MA Antagonist DM0DWSR RN Bradyzide, a potent non-peptide B(2) bradykinin receptor antagonist with long-lasting oral activity in animal models of inflammatory hyperalgesia. Br J Pharmacol. 2000 Jan;129(1):77-86. DM0DWSR RU https://pubmed.ncbi.nlm.nih.gov/10694205 DMIZ9ON DI DMIZ9ON DMIZ9ON DN BRD1240 DMIZ9ON MI TTTK3BH DMIZ9ON MN Vacuolar-type proton ATPase (v-ATPase) DMIZ9ON MT DTT DMIZ9ON MA Inhibitor DMIZ9ON RN Lysosomes as a therapeutic target. Nat Rev Drug Discov. 2019 Dec;18(12):923-948. DMIZ9ON RU https://pubmed.ncbi.nlm.nih.gov/31477883 DMFAVB5 DI DMFAVB5 DMFAVB5 DN BRD9539 DMFAVB5 MI TTS6RZT DMFAVB5 MN Histone-lysine N-methyltransferase EHMT2 (EHMT2) DMFAVB5 MT DTT DMFAVB5 MA Inhibitor DMFAVB5 RN A small-molecule probe of the histone methyltransferase G9a induces cellular senescence in pancreatic adenocarcinoma. ACS Chem Biol. 2012 Jul 20;7(7):1152-7. DMFAVB5 RU https://pubmed.ncbi.nlm.nih.gov/22536950 DM21ZBU DI DM21ZBU DM21ZBU DN Breceptin DM21ZBU MI TTGY8IW DM21ZBU MN B2 bradykinin receptor (BDKRB2) DM21ZBU MT DTT DM21ZBU MA Modulator DM21ZBU RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 42). DM21ZBU RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=42 DM3EIBU DI DM3EIBU DM3EIBU DN BREMAZOCINE DM3EIBU MI TTKWM86 DM3EIBU MN Opioid receptor mu (MOP) DM3EIBU MT DTT DM3EIBU MA Inhibitor DM3EIBU RN Electrophilic alpha-methylene-gamma-lactone and isothiocyanate opioid ligands related to etorphine. J Med Chem. 1990 Aug;33(8):2286-96. DM3EIBU RU https://pubmed.ncbi.nlm.nih.gov/2165166 DM2JPX7 DI DM2JPX7 DM2JPX7 DN BRIFENTANIL DM2JPX7 MI TTN4QDT DM2JPX7 MN Opioid receptor (OPR) DM2JPX7 MT DTT DM2JPX7 MA Modulator DM2JPX7 RN Synthesis and pharmacological evaluation of a series of new 3-methyl-1,4-disubstituted-piperidine analgesics. J Med Chem. 1990 Oct;33(10):2876-82. DM2JPX7 RU https://pubmed.ncbi.nlm.nih.gov/2170652 DMTM7W0 DI DMTM7W0 DMTM7W0 DN BRL 43694A DMTM7W0 MI TTNXLKE DMTM7W0 MN 5-HT 3 receptor (5HT3R) DMTM7W0 MT DTT DMTM7W0 MA Antagonist DMTM7W0 RN BRL 43694A--a 5-hydroxytryptamine receptor blocker as an antiemetic in cytostatic therapy. Schweiz Med Wochenschr. 1989 Jun 10;119(23):831-4. DMTM7W0 RU https://pubmed.ncbi.nlm.nih.gov/2549616 DM3WPO4 DI DM3WPO4 DM3WPO4 DN BRL 44408 DM3WPO4 MI TTWG9A4 DM3WPO4 MN Adrenergic receptor alpha-2A (ADRA2A) DM3WPO4 MT DTT DM3WPO4 MA Antagonist DM3WPO4 RN Potent alpha(2A)-adrenoceptor-mediated vasoconstriction by brimonidine in porcine ciliary arteries. Invest Ophthalmol Vis Sci. 2001 Aug;42(9):2049-55. DM3WPO4 RU https://pubmed.ncbi.nlm.nih.gov/11481271 DM16GUV DI DM16GUV DM16GUV DN BRL 52537 hydrochloride DM16GUV MI TTQW87Y DM16GUV MN Opioid receptor kappa (OPRK1) DM16GUV MT DTT DM16GUV MA Agonist DM16GUV RN Kappa-opioid receptor selectivity for ischemic neuroprotection with BRL 52537 in rats. Anesth Analg. 2003 Dec;97(6):1776-83. DM16GUV RU https://pubmed.ncbi.nlm.nih.gov/14633559 DM6XO72 DI DM6XO72 DM6XO72 DN BRL 52974 DM6XO72 MI TTQW87Y DM6XO72 MN Opioid receptor kappa (OPRK1) DM6XO72 MT DTT DM6XO72 MA Agonist DM6XO72 RN The antitussive activity of delta-opioid receptor stimulation in guinea pigs. J Pharmacol Exp Ther. 2000 Feb;292(2):803-9. DM6XO72 RU https://pubmed.ncbi.nlm.nih.gov/10640321 DMM61Y2 DI DMM61Y2 DMM61Y2 DN BRL-15572 DMM61Y2 MI TTSQIFT DMM61Y2 MN 5-HT 1A receptor (HTR1A) DMM61Y2 MT DTT DMM61Y2 MA Agonist DMM61Y2 RN SB-216641 and BRL-15572--compounds to pharmacologically discriminate h5-HT1B and h5-HT1D receptors. Naunyn Schmiedebergs Arch Pharmacol. 1997 Sep;356(3):312-20. DMM61Y2 RU https://pubmed.ncbi.nlm.nih.gov/9303567 DMM61Y2 DI DMM61Y2 DMM61Y2 DN BRL-15572 DMM61Y2 MI TTK8CXU DMM61Y2 MN 5-HT 1B receptor (HTR1B) DMM61Y2 MT DTT DMM61Y2 MA Agonist DMM61Y2 RN SB-216641 and BRL-15572--compounds to pharmacologically discriminate h5-HT1B and h5-HT1D receptors. Naunyn Schmiedebergs Arch Pharmacol. 1997 Sep;356(3):312-20. DMM61Y2 RU https://pubmed.ncbi.nlm.nih.gov/9303567 DMM61Y2 DI DMM61Y2 DMM61Y2 DN BRL-15572 DMM61Y2 MI TT6MSOK DMM61Y2 MN 5-HT 1D receptor (HTR1D) DMM61Y2 MT DTT DMM61Y2 MA Agonist DMM61Y2 RN SB-216641 and BRL-15572--compounds to pharmacologically discriminate h5-HT1B and h5-HT1D receptors. Naunyn Schmiedebergs Arch Pharmacol. 1997 Sep;356(3):312-20. DMM61Y2 RU https://pubmed.ncbi.nlm.nih.gov/9303567 DMM61Y2 DI DMM61Y2 DMM61Y2 DN BRL-15572 DMM61Y2 MI TTCPG9S DMM61Y2 MN 5-HT 1E receptor (HTR1E) DMM61Y2 MT DTT DMM61Y2 MA Agonist DMM61Y2 RN SB-216641 and BRL-15572--compounds to pharmacologically discriminate h5-HT1B and h5-HT1D receptors. Naunyn Schmiedebergs Arch Pharmacol. 1997 Sep;356(3):312-20. DMM61Y2 RU https://pubmed.ncbi.nlm.nih.gov/9303567 DMM61Y2 DI DMM61Y2 DMM61Y2 DN BRL-15572 DMM61Y2 MI TT0MI3F DMM61Y2 MN 5-HT 1F receptor (HTR1F) DMM61Y2 MT DTT DMM61Y2 MA Agonist DMM61Y2 RN SB-216641 and BRL-15572--compounds to pharmacologically discriminate h5-HT1B and h5-HT1D receptors. Naunyn Schmiedebergs Arch Pharmacol. 1997 Sep;356(3):312-20. DMM61Y2 RU https://pubmed.ncbi.nlm.nih.gov/9303567 DMM61Y2 DI DMM61Y2 DMM61Y2 DN BRL-15572 DMM61Y2 MI TTJQOD7 DMM61Y2 MN 5-HT 2A receptor (HTR2A) DMM61Y2 MT DTT DMM61Y2 MA Agonist DMM61Y2 RN SB-216641 and BRL-15572--compounds to pharmacologically discriminate h5-HT1B and h5-HT1D receptors. Naunyn Schmiedebergs Arch Pharmacol. 1997 Sep;356(3):312-20. DMM61Y2 RU https://pubmed.ncbi.nlm.nih.gov/9303567 DMM61Y2 DI DMM61Y2 DMM61Y2 DN BRL-15572 DMM61Y2 MI TT0K1SC DMM61Y2 MN 5-HT 2B receptor (HTR2B) DMM61Y2 MT DTT DMM61Y2 MA Agonist DMM61Y2 RN SB-216641 and BRL-15572--compounds to pharmacologically discriminate h5-HT1B and h5-HT1D receptors. Naunyn Schmiedebergs Arch Pharmacol. 1997 Sep;356(3):312-20. DMM61Y2 RU https://pubmed.ncbi.nlm.nih.gov/9303567 DMM61Y2 DI DMM61Y2 DMM61Y2 DN BRL-15572 DMM61Y2 MI TTWJBZ5 DMM61Y2 MN 5-HT 2C receptor (HTR2C) DMM61Y2 MT DTT DMM61Y2 MA Agonist DMM61Y2 RN SB-216641 and BRL-15572--compounds to pharmacologically discriminate h5-HT1B and h5-HT1D receptors. Naunyn Schmiedebergs Arch Pharmacol. 1997 Sep;356(3):312-20. DMM61Y2 RU https://pubmed.ncbi.nlm.nih.gov/9303567 DMM61Y2 DI DMM61Y2 DMM61Y2 DN BRL-15572 DMM61Y2 MI TTJS8PY DMM61Y2 MN 5-HT 6 receptor (HTR6) DMM61Y2 MT DTT DMM61Y2 MA Agonist DMM61Y2 RN SB-216641 and BRL-15572--compounds to pharmacologically discriminate h5-HT1B and h5-HT1D receptors. Naunyn Schmiedebergs Arch Pharmacol. 1997 Sep;356(3):312-20. DMM61Y2 RU https://pubmed.ncbi.nlm.nih.gov/9303567 DMSB4EW DI DMSB4EW DMSB4EW DN BRL-24682 DMSB4EW MI TTPC4TU DMSB4EW MN 5-HT 3A receptor (HTR3A) DMSB4EW MT DTT DMSB4EW MA Inhibitor DMSB4EW RN Synthesis and structure-affinity relationships of novel N-(1-ethyl-4-methylhexahydro-1,4-diazepin-6-yl)pyridine-3-carboxamides with potent serotoni... J Med Chem. 2003 Feb 27;46(5):702-15. DMSB4EW RU https://pubmed.ncbi.nlm.nih.gov/12593651 DMSB4EW DI DMSB4EW DMSB4EW DN BRL-24682 DMSB4EW MI TTR6K75 DMSB4EW MN 5-HT 3B receptor (HTR3B) DMSB4EW MT DTT DMSB4EW MA Inhibitor DMSB4EW RN Synthesis and structure-affinity relationships of novel N-(1-ethyl-4-methylhexahydro-1,4-diazepin-6-yl)pyridine-3-carboxamides with potent serotoni... J Med Chem. 2003 Feb 27;46(5):702-15. DMSB4EW RU https://pubmed.ncbi.nlm.nih.gov/12593651 DMD0YL1 DI DMD0YL1 DMD0YL1 DN BRL-25594 DMD0YL1 MI TTEX248 DMD0YL1 MN Dopamine D2 receptor (D2R) DMD0YL1 MT DTT DMD0YL1 MA Inhibitor DMD0YL1 RN Synthesis and structure-affinity relationships of novel N-(1-ethyl-4-methylhexahydro-1,4-diazepin-6-yl)pyridine-3-carboxamides with potent serotoni... J Med Chem. 2003 Feb 27;46(5):702-15. DMD0YL1 RU https://pubmed.ncbi.nlm.nih.gov/12593651 DMQ4MFY DI DMQ4MFY DMQ4MFY DN BRL-26175 DMQ4MFY MI TTEX248 DMQ4MFY MN Dopamine D2 receptor (D2R) DMQ4MFY MT DTT DMQ4MFY MA Inhibitor DMQ4MFY RN 18F-labeled benzamides for studying the dopamine D2 receptor with positron emission tomography. J Med Chem. 1993 Nov 12;36(23):3707-20. DMQ4MFY RU https://pubmed.ncbi.nlm.nih.gov/8246241 DMRI49D DI DMRI49D DMRI49D DN BRL-36378 DMRI49D MI TTL69WB DMRI49D MN Angiotensin-converting enzyme (ACE) DMRI49D MT DTT DMRI49D MA Modulator DMRI49D RN Antihypertensive and angiotensin converting enzyme inhibitory activities of a novel dihydrobenzofuran analogue. Arzneimittelforschung. 1988 Apr;38(4):531-6. DMRI49D RU https://www.ncbi.nlm.nih.gov/pubmed/2840917 DMT4NM5 DI DMT4NM5 DMT4NM5 DN BRL-48482 DMT4NM5 MI TTT2SVW DMT4NM5 MN PPAR-gamma messenger RNA (PPARG mRNA) DMT4NM5 MT DTT DMT4NM5 MA Inhibitor DMT4NM5 RN Non thiazolidinedione antihyperglycaemic agents. 2: alpha-Carbon substituted beta-phenylpropanoic acids1, Bioorg. Med. Chem. Lett. 6(17):2127-2130 (1996). DMT4NM5 RU http://www.sciencedirect.com/science/article/pii/0960894X96003824 DMV2XUM DI DMV2XUM DMV2XUM DN BRL50481 DMV2XUM MI TTWIEY9 DMV2XUM MN Phosphodiesterase 7B (PDE7B) DMV2XUM MT DTT DMV2XUM MA Inhibitor DMV2XUM RN New classes of PDE7 inhibitors identified by a fission yeast-based HTS. J Biomol Screen. 2010 Apr;15(4):359-67. DMV2XUM RU https://pubmed.ncbi.nlm.nih.gov/20228279 DM3TWBU DI DM3TWBU DM3TWBU DN BRL54443 DM3TWBU MI TTCPG9S DM3TWBU MN 5-HT 1E receptor (HTR1E) DM3TWBU MT DTT DM3TWBU MA Agonist DM3TWBU RN Characterization of the serotonin receptor mediating contraction in the mouse thoracic aorta and signal pathway coupling. J Pharmacol Exp Ther. 2001 Apr;297(1):88-95. DM3TWBU RU https://pubmed.ncbi.nlm.nih.gov/11259531 DM2J1FA DI DM2J1FA DM2J1FA DN BRL-54504AX DM2J1FA MI TTNJYV2 DM2J1FA MN Gamma-aminobutyric acid receptor (GAR) DM2J1FA MT DTT DM2J1FA MA Inhibitor DM2J1FA RN Isosteric replacement of the indole nucleus by benzothiophene in a series of pyrido[2,3-b]indoles with potential anxiolytic activity, Bioorg. Med. Chem. Lett. 5(22):2589-2592 (1995). DM2J1FA RU http://www.sciencedirect.com/science/article/pii/0960894X95004508 DMEMZ6Q DI DMEMZ6Q DMEMZ6Q DN BRL-55473 DMEMZ6Q MI TTZ9SOR DMEMZ6Q MN Muscarinic acetylcholine receptor M1 (CHRM1) DMEMZ6Q MT DTT DMEMZ6Q MA Inhibitor DMEMZ6Q RN A novel and selective class of azabicyclic muscarinic agonists incorporating an N-methoxy imidoyl halide or nitrile functionality, Bioorg. Med. Chem. Lett. 2(8):791-796 (1992). DMEMZ6Q RU http://www.sciencedirect.com/science/article/pii/S0960894X00805338 DMEMZ6Q DI DMEMZ6Q DMEMZ6Q DN BRL-55473 DMEMZ6Q MI TTYEG6Q DMEMZ6Q MN Muscarinic acetylcholine receptor M2 (CHRM2) DMEMZ6Q MT DTT DMEMZ6Q MA Inhibitor DMEMZ6Q RN A novel and selective class of azabicyclic muscarinic agonists incorporating an N-methoxy imidoyl halide or nitrile functionality, Bioorg. Med. Chem. Lett. 2(8):791-796 (1992). DMEMZ6Q RU http://www.sciencedirect.com/science/article/pii/S0960894X00805338 DMEMZ6Q DI DMEMZ6Q DMEMZ6Q DN BRL-55473 DMEMZ6Q MI TTQ13Z5 DMEMZ6Q MN Muscarinic acetylcholine receptor M3 (CHRM3) DMEMZ6Q MT DTT DMEMZ6Q MA Inhibitor DMEMZ6Q RN A novel and selective class of azabicyclic muscarinic agonists incorporating an N-methoxy imidoyl halide or nitrile functionality, Bioorg. Med. Chem. Lett. 2(8):791-796 (1992). DMEMZ6Q RU http://www.sciencedirect.com/science/article/pii/S0960894X00805338 DMEMZ6Q DI DMEMZ6Q DMEMZ6Q DN BRL-55473 DMEMZ6Q MI TTQ3JTF DMEMZ6Q MN Muscarinic acetylcholine receptor M4 (CHRM4) DMEMZ6Q MT DTT DMEMZ6Q MA Inhibitor DMEMZ6Q RN A novel and selective class of azabicyclic muscarinic agonists incorporating an N-methoxy imidoyl halide or nitrile functionality, Bioorg. Med. Chem. Lett. 2(8):791-796 (1992). DMEMZ6Q RU http://www.sciencedirect.com/science/article/pii/S0960894X00805338 DMEMZ6Q DI DMEMZ6Q DMEMZ6Q DN BRL-55473 DMEMZ6Q MI TTH18TF DMEMZ6Q MN Muscarinic acetylcholine receptor M5 (CHRM5) DMEMZ6Q MT DTT DMEMZ6Q MA Inhibitor DMEMZ6Q RN A novel and selective class of azabicyclic muscarinic agonists incorporating an N-methoxy imidoyl halide or nitrile functionality, Bioorg. Med. Chem. Lett. 2(8):791-796 (1992). DMEMZ6Q RU http://www.sciencedirect.com/science/article/pii/S0960894X00805338 DMZMWVX DI DMZMWVX DMZMWVX DN BRN-0471734 DMZMWVX MI DED2FW3 DMZMWVX MN Aldo-keto reductase 1A1 (AKR1A1) DMZMWVX MT DME DMZMWVX MA Metabolism DMZMWVX RN The C-terminal loop of aldehyde reductase determines the substrate and inhibitor specificity. Biochemistry. 1996 Nov 12;35(45):14276-80. DMZMWVX RU https://www.ncbi.nlm.nih.gov/pubmed/?term=8916913 DMOTU4P DI DMOTU4P DMOTU4P DN BRN-1980310 DMOTU4P MI DENZ6B1 DMOTU4P MN UDP-glucuronosyltransferase 2B15 (UGT2B15) DMOTU4P MT DME DMOTU4P MA Metabolism DMOTU4P RN Importance of UDP-glucuronosyltransferase 1A10 (UGT1A10) in the detoxification of polycyclic aromatic hydrocarbons: decreased glucuronidative activity of the UGT1A10139Lys isoform. Drug Metab Dispos. 2006 Jun;34(6):943-9. DMOTU4P RU https://www.ncbi.nlm.nih.gov/pubmed/?term=16510539 DMOTU4P DI DMOTU4P DMOTU4P DN BRN-1980310 DMOTU4P MI DEAZDL8 DMOTU4P MN UDP-glucuronosyltransferase 2B17 (UGT2B17) DMOTU4P MT DME DMOTU4P MA Metabolism DMOTU4P RN Importance of UDP-glucuronosyltransferase 1A10 (UGT1A10) in the detoxification of polycyclic aromatic hydrocarbons: decreased glucuronidative activity of the UGT1A10139Lys isoform. Drug Metab Dispos. 2006 Jun;34(6):943-9. DMOTU4P RU https://www.ncbi.nlm.nih.gov/pubmed/?term=16510539 DMC9Q4D DI DMC9Q4D DMC9Q4D DN BRN-1999480 DMC9Q4D MI DESD26P DMC9Q4D MN UDP-glucuronosyltransferase 1A6 (UGT1A6) DMC9Q4D MT DME DMC9Q4D MA Metabolism DMC9Q4D RN Structural and functional studies of UDP-glucuronosyltransferases. Drug Metab Rev. 1999 Nov;31(4):817-99. DMC9Q4D RU https://www.ncbi.nlm.nih.gov/pubmed/?term=10575553 DM87VP6 DI DM87VP6 DM87VP6 DN BRN-2330710 DM87VP6 MI DEM1HNL DM87VP6 MN Alcohol dehydrogenase class-I gamma (ADH1C) DM87VP6 MT DME DM87VP6 MA Metabolism DM87VP6 RN Oxidation of alcohols and reduction of aldehydes derived from methyl- and dimethylpyrenes by cDNA-expressed human alcohol dehydrogenases. Toxicology. 2008 Mar 12;245(1-2):65-75. DM87VP6 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=18242813 DM87VP6 DI DM87VP6 DM87VP6 DN BRN-2330710 DM87VP6 MI DEOCWU3 DM87VP6 MN Alcohol dehydrogenase class-II (ADH4) DM87VP6 MT DME DM87VP6 MA Metabolism DM87VP6 RN Oxidation of alcohols and reduction of aldehydes derived from methyl- and dimethylpyrenes by cDNA-expressed human alcohol dehydrogenases. Toxicology. 2008 Mar 12;245(1-2):65-75. DM87VP6 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=18242813 DM4KXT0 DI DM4KXT0 DM4KXT0 DN BRN-3548355 DM4KXT0 MI DE7P2FB DM4KXT0 MN Aldo-keto reductase 1C1 (AKR1C1) DM4KXT0 MT DME DM4KXT0 MA Metabolism DM4KXT0 RN Characterization of enzymes participating in carbonyl reduction of 4-methylnitrosamino-1-(3-pyridyl)-1-butanone (NNK) in human placenta. Chem Biol Interact. 2001 Jan 30;130-132(1-3):737-48. DM4KXT0 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=11306090 DM4KXT0 DI DM4KXT0 DM4KXT0 DN BRN-3548355 DM4KXT0 MI DEOY5ZM DM4KXT0 MN Aldo-keto reductase 1C2 (AKR1C2) DM4KXT0 MT DME DM4KXT0 MA Metabolism DM4KXT0 RN Characterization of enzymes participating in carbonyl reduction of 4-methylnitrosamino-1-(3-pyridyl)-1-butanone (NNK) in human placenta. Chem Biol Interact. 2001 Jan 30;130-132(1-3):737-48. DM4KXT0 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=11306090 DM4KXT0 DI DM4KXT0 DM4KXT0 DN BRN-3548355 DM4KXT0 MI DEAJN47 DM4KXT0 MN Aldo-keto reductase 1C4 (AKR1C4) DM4KXT0 MT DME DM4KXT0 MA Metabolism DM4KXT0 RN Characterization of enzymes participating in carbonyl reduction of 4-methylnitrosamino-1-(3-pyridyl)-1-butanone (NNK) in human placenta. Chem Biol Interact. 2001 Jan 30;130-132(1-3):737-48. DM4KXT0 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=11306090 DM4KXT0 DI DM4KXT0 DM4KXT0 DN BRN-3548355 DM4KXT0 MI DE9JFMC DM4KXT0 MN NADPH-dependent carbonyl reductase 1 (CBR1) DM4KXT0 MT DME DM4KXT0 MA Metabolism DM4KXT0 RN Characterization of enzymes participating in carbonyl reduction of 4-methylnitrosamino-1-(3-pyridyl)-1-butanone (NNK) in human placenta. Chem Biol Interact. 2001 Jan 30;130-132(1-3):737-48. DM4KXT0 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=11306090 DM9UF02 DI DM9UF02 DM9UF02 DN Brocresine DM9UF02 MI TTV9GOF DM9UF02 MN Histidine decarboxylase (HDC) DM9UF02 MT DTT DM9UF02 MA Inhibitor DM9UF02 RN Histamine in brain--its role in regulation of seizure susceptibility. Epilepsy Res. 1991 Nov-Dec;10(2-3):111-8. DM9UF02 RU https://pubmed.ncbi.nlm.nih.gov/1817952 DM7OF6N DI DM7OF6N DM7OF6N DN Brodimoprim-4,6-Dicarboxylate DM7OF6N MI TT9SL3Q DM7OF6N MN Polypeptide deformylase (PDF) DM7OF6N MT DTT DM7OF6N MA Inhibitor DM7OF6N RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DM7OF6N RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMC4PF0 DI DMC4PF0 DMC4PF0 DN Brolamfetamine DMC4PF0 MI TTSQIFT DMC4PF0 MN 5-HT 1A receptor (HTR1A) DMC4PF0 MT DTT DMC4PF0 MA Inhibitor DMC4PF0 RN 5-HT1 and 5-HT2 binding characteristics of 1-(2,5-dimethoxy-4-bromophenyl)-2-aminopropane analogues. J Med Chem. 1986 Feb;29(2):194-9. DMC4PF0 RU https://pubmed.ncbi.nlm.nih.gov/3950904 DMC4PF0 DI DMC4PF0 DMC4PF0 DN Brolamfetamine DMC4PF0 MI TT6MSOK DMC4PF0 MN 5-HT 1D receptor (HTR1D) DMC4PF0 MT DTT DMC4PF0 MA Inhibitor DMC4PF0 RN 5-HT1 and 5-HT2 binding characteristics of 1-(2,5-dimethoxy-4-bromophenyl)-2-aminopropane analogues. J Med Chem. 1986 Feb;29(2):194-9. DMC4PF0 RU https://pubmed.ncbi.nlm.nih.gov/3950904 DMC4PF0 DI DMC4PF0 DMC4PF0 DN Brolamfetamine DMC4PF0 MI TTJQOD7 DMC4PF0 MN 5-HT 2A receptor (HTR2A) DMC4PF0 MT DTT DMC4PF0 MA Inhibitor DMC4PF0 RN 'Hybrid' benzofuran-benzopyran congeners as rigid analogs of hallucinogenic phenethylamines. Bioorg Med Chem. 2008 Jun 1;16(11):6242-51. DMC4PF0 RU https://pubmed.ncbi.nlm.nih.gov/18467103 DMMC4BY DI DMMC4BY DMMC4BY DN Brominide tartrate DMMC4BY MI TTQ8AFT DMMC4BY MN Adrenergic receptor Alpha-2 (ADRA2) DMMC4BY MT DTT DMMC4BY MA Agonist DMMC4BY RN Alpha(2A)-adrenoceptor: G(alphai1) protein-mediated pertussis toxin-resistant attenuation of G(s) coupling to the cyclic AMP pathway. Biochem Pharmacol. 2000 Jun 15;59(12):1531-8. DMMC4BY RU https://pubmed.ncbi.nlm.nih.gov/10799649 DMTBO7F DI DMTBO7F DMTBO7F DN bromoacetone DMTBO7F MI TTELV3W DMTBO7F MN Transformation-sensitive protein p120 (TRPA1) DMTBO7F MT DTT DMTBO7F MA Activator DMTBO7F RN Transient receptor potential ankyrin 1 antagonists block the noxious effects of toxic industrial isocyanates and tear gases. FASEB J. 2009 Apr;23(4):1102-14. DMTBO7F RU https://pubmed.ncbi.nlm.nih.gov/19036859 DMXTVZ8 DI DMXTVZ8 DMXTVZ8 DN bromocresol green DMXTVZ8 MI TTKVTQO DMXTVZ8 MN Prostaglandin transporter (SLC21A2) DMXTVZ8 MT DTT DMXTVZ8 MA Inhibitor DMXTVZ8 RN Identification and characterization of a prostaglandin transporter. Science. 1995 May 12;268(5212):866-9. DMXTVZ8 RU https://pubmed.ncbi.nlm.nih.gov/7754369 DMX2U7G DI DMX2U7G DMX2U7G DN bromo-deaza-SAH DMX2U7G MI TTSZ8T1 DMX2U7G MN Histone-lysine N-methyltransferase (HLNM) DMX2U7G MT DTT DMX2U7G MA Inhibitor DMX2U7G RN Bromo-deaza-SAH: a potent and selective DOT1L inhibitor. Bioorg Med Chem. 2013 Apr 1;21(7):1787-94. DMX2U7G RU https://pubmed.ncbi.nlm.nih.gov/23433670 DM0D7LA DI DM0D7LA DM0D7LA DN BROMODEOXYURIDINE DM0D7LA MI TT5B8AX DM0D7LA MN Mycobacterium Thymidine monophosphate kinase (MycB tmk) DM0D7LA MT DTT DM0D7LA MA Inhibitor DM0D7LA RN Substituted benzyl-pyrimidines targeting thymidine monophosphate kinase of Mycobacterium tuberculosis: synthesis and in vitro anti-mycobacterial ac... Bioorg Med Chem. 2008 Jun 1;16(11):6075-85. DM0D7LA RU https://pubmed.ncbi.nlm.nih.gov/18467107 DMKQ0CA DI DMKQ0CA DMKQ0CA DN bromoenol lactone DMKQ0CA MI TTDP1UC DMKQ0CA MN Fatty acid amide hydrolase (FAAH) DMKQ0CA MT DTT DMKQ0CA MA Inhibitor DMKQ0CA RN Discovery and development of fatty acid amide hydrolase (FAAH) inhibitors. J Med Chem. 2008 Dec 11;51(23):7327-43. DMKQ0CA RU https://pubmed.ncbi.nlm.nih.gov/18983142 DMKQ0CA DI DMKQ0CA DMKQ0CA DN bromoenol lactone DMKQ0CA MI TT32NQ1 DMKQ0CA MN Short transient receptor potential channel 5 (TRPC5) DMKQ0CA MT DTT DMKQ0CA MA Blocker (channel blocker) DMKQ0CA RN Bromoenol lactone inhibits voltage-gated Ca2+ and transient receptor potential canonical channels. J Pharmacol Exp Ther. 2011 Nov;339(2):329-40. DMKQ0CA RU https://pubmed.ncbi.nlm.nih.gov/21795434 DMKFTW8 DI DMKFTW8 DMKFTW8 DN Bromo-WR99210 DMKFTW8 MI TT9SL3Q DMKFTW8 MN Polypeptide deformylase (PDF) DMKFTW8 MT DTT DMKFTW8 MA Inhibitor DMKFTW8 RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMKFTW8 RU https://pubmed.ncbi.nlm.nih.gov/17139284 DM9W2ZV DI DM9W2ZV DM9W2ZV DN Bromsulphthalein DM9W2ZV MI DTE2B1D DM9W2ZV MN Organic anion transporting polypeptide 1A2 (SLCO1A2) DM9W2ZV MT DTP DM9W2ZV MA Substrate DM9W2ZV RN Organic anion-transporting polypeptide B (OATP-B) and its functional comparison with three other OATPs of human liver. Gastroenterology. 2001 Feb;120(2):525-33. DM9W2ZV RU http://www.ncbi.nlm.nih.gov/pubmed/11159893 DM9W2ZV DI DM9W2ZV DM9W2ZV DN Bromsulphthalein DM9W2ZV MI DT3D8F0 DM9W2ZV MN Organic anion transporting polypeptide 1B1 (SLCO1B1) DM9W2ZV MT DTP DM9W2ZV MA Substrate DM9W2ZV RN Organic anion-transporting polypeptide B (OATP-B) and its functional comparison with three other OATPs of human liver. Gastroenterology. 2001 Feb;120(2):525-33. DM9W2ZV RU http://www.ncbi.nlm.nih.gov/pubmed/11159893 DM9W2ZV DI DM9W2ZV DM9W2ZV DN Bromsulphthalein DM9W2ZV MI DT9C1TS DM9W2ZV MN Organic anion transporting polypeptide 1B3 (SLCO1B3) DM9W2ZV MT DTP DM9W2ZV MA Substrate DM9W2ZV RN Organic anion-transporting polypeptide B (OATP-B) and its functional comparison with three other OATPs of human liver. Gastroenterology. 2001 Feb;120(2):525-33. DM9W2ZV RU http://www.ncbi.nlm.nih.gov/pubmed/11159893 DM9W2ZV DI DM9W2ZV DM9W2ZV DN Bromsulphthalein DM9W2ZV MI DTPFTEQ DM9W2ZV MN Organic anion transporting polypeptide 2B1 (SLCO2B1) DM9W2ZV MT DTP DM9W2ZV MA Substrate DM9W2ZV RN Organic anion-transporting polypeptide (OATP) 2B1 contributes to the cellular uptake of theaflavin. Drug Metab Pharmacokinet. 2017 Apr;32(2):145-150. DM9W2ZV RU http://www.ncbi.nlm.nih.gov/pubmed/28190756 DM9W2ZV DI DM9W2ZV DM9W2ZV DN Bromsulphthalein DM9W2ZV MI TTKVTQO DM9W2ZV MN Prostaglandin transporter (SLC21A2) DM9W2ZV MT DTT DM9W2ZV MA Inhibitor DM9W2ZV RN Identification and characterization of a prostaglandin transporter. Science. 1995 May 12;268(5212):866-9. DM9W2ZV RU https://pubmed.ncbi.nlm.nih.gov/7754369 DMB9SEI DI DMB9SEI DMB9SEI DN Broussoflavonol F DMB9SEI MI TTSZLWK DMB9SEI MN Aromatase (CYP19A1) DMB9SEI MT DTT DMB9SEI MA Inhibitor DMB9SEI RN Aromatase inhibitors from Broussonetia papyrifera. J Nat Prod. 2001 Oct;64(10):1286-93. DMB9SEI RU https://pubmed.ncbi.nlm.nih.gov/11678652 DMXFN6H DI DMXFN6H DMXFN6H DN BROUSSONIN A DMXFN6H MI TTZAYWL DMXFN6H MN Estrogen receptor (ESR) DMXFN6H MT DTT DMXFN6H MA Inhibitor DMXFN6H RN New estrogenic compounds isolated from Broussonetia kazinoki. Bioorg Med Chem Lett. 2010 Jun 15;20(12):3764-7. DMXFN6H RU https://pubmed.ncbi.nlm.nih.gov/20493686 DMXFN6H DI DMXFN6H DMXFN6H DN BROUSSONIN A DMXFN6H MI TTOM3J0 DMXFN6H MN Estrogen receptor beta (ESR2) DMXFN6H MT DTT DMXFN6H MA Inhibitor DMXFN6H RN New estrogenic compounds isolated from Broussonetia kazinoki. Bioorg Med Chem Lett. 2010 Jun 15;20(12):3764-7. DMXFN6H RU https://pubmed.ncbi.nlm.nih.gov/20493686 DMKM9F0 DI DMKM9F0 DMKM9F0 DN Broussonin C DMKM9F0 MI TTULVH8 DMKM9F0 MN Tyrosinase (TYR) DMKM9F0 MT DTT DMKM9F0 MA Inhibitor DMKM9F0 RN Tyrosinase inhibitory effects of 1,3-diphenylpropanes from Broussonetia kazinoki. Bioorg Med Chem. 2009 Jan 1;17(1):35-41. DMKM9F0 RU https://pubmed.ncbi.nlm.nih.gov/19046886 DMPGEO1 DI DMPGEO1 DMPGEO1 DN BrP-LPA DMPGEO1 MI TTQ6S1K DMPGEO1 MN Lysophosphatidic acid receptor 1 (LPAR1) DMPGEO1 MT DTT DMPGEO1 MA Antagonist DMPGEO1 RN Dual activity lysophosphatidic acid receptor pan-antagonist/autotaxin inhibitor reduces breast cancer cell migration in vitro and causes tumor regression in vivo. Cancer Res. 2009 Jul 1;69(13):5441-9. DMPGEO1 RU https://pubmed.ncbi.nlm.nih.gov/19509223 DMPGEO1 DI DMPGEO1 DMPGEO1 DN BrP-LPA DMPGEO1 MI TTB7Y8I DMPGEO1 MN Lysophosphatidic acid receptor 2 (LPAR2) DMPGEO1 MT DTT DMPGEO1 MA Antagonist DMPGEO1 RN Dual activity lysophosphatidic acid receptor pan-antagonist/autotaxin inhibitor reduces breast cancer cell migration in vitro and causes tumor regression in vivo. Cancer Res. 2009 Jul 1;69(13):5441-9. DMPGEO1 RU https://pubmed.ncbi.nlm.nih.gov/19509223 DM50RUD DI DM50RUD DM50RUD DN brucine DM50RUD MI TTOXS3C DM50RUD MN Muscarinic acetylcholine receptor (CHRM) DM50RUD MT DTT DM50RUD MA Modulator (allosteric modulator) DM50RUD RN Subtype-selective positive cooperative interactions between brucine analogues and acetylcholine at muscarinic receptors: radioligand binding studies. Mol Pharmacol. 1998 Mar;53(3):573-89. DM50RUD RU https://pubmed.ncbi.nlm.nih.gov/9495826 DM50RUD DI DM50RUD DM50RUD DN brucine DM50RUD MI TTQ13Z5 DM50RUD MN Muscarinic acetylcholine receptor M3 (CHRM3) DM50RUD MT DTT DM50RUD MA Modulator (allosteric modulator) DM50RUD RN Subtype-selective positive cooperative interactions between brucine analogues and acetylcholine at muscarinic receptors: radioligand binding studies. Mol Pharmacol. 1998 Mar;53(3):573-89. DM50RUD RU https://pubmed.ncbi.nlm.nih.gov/9495826 DMKZM1L DI DMKZM1L DMKZM1L DN Brutieridin DMKZM1L MI TTPADOQ DMKZM1L MN HMG-CoA reductase (HMGCR) DMKZM1L MT DTT DMKZM1L MA Inhibitor DMKZM1L RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 639). DMKZM1L RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=639 DM1VF6H DI DM1VF6H DM1VF6H DN BS 7581 DM1VF6H MI TTVG215 DM1VF6H MN Debrisoquine 4-hydroxylase (CYP2D6) DM1VF6H MT DTT DM1VF6H MA Inhibitor DM1VF6H RN Catalytic site prediction and virtual screening of cytochrome P450 2D6 substrates by consideration of water and rescoring in automated docking. J Med Chem. 2006 Apr 20;49(8):2417-30. DM1VF6H RU https://pubmed.ncbi.nlm.nih.gov/16610785 DMDYNBT DI DMDYNBT DMDYNBT DN BS 7840 DMDYNBT MI TTVG215 DMDYNBT MN Debrisoquine 4-hydroxylase (CYP2D6) DMDYNBT MT DTT DMDYNBT MA Inhibitor DMDYNBT RN Catalytic site prediction and virtual screening of cytochrome P450 2D6 substrates by consideration of water and rescoring in automated docking. J Med Chem. 2006 Apr 20;49(8):2417-30. DMDYNBT RU https://pubmed.ncbi.nlm.nih.gov/16610785 DMQ2FDA DI DMQ2FDA DMQ2FDA DN BS 9106 DMQ2FDA MI TTVG215 DMQ2FDA MN Debrisoquine 4-hydroxylase (CYP2D6) DMQ2FDA MT DTT DMQ2FDA MA Inhibitor DMQ2FDA RN Catalytic site prediction and virtual screening of cytochrome P450 2D6 substrates by consideration of water and rescoring in automated docking. J Med Chem. 2006 Apr 20;49(8):2417-30. DMQ2FDA RU https://pubmed.ncbi.nlm.nih.gov/16610785 DMLXFHD DI DMLXFHD DMLXFHD DN BS-194 DMLXFHD MI TTMBO1Z DMLXFHD MN Cyclin-dependent kinase (CDK) DMLXFHD MT DTT DMLXFHD MA Inhibitor DMLXFHD RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 8176). DMLXFHD RU http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=8176 DMJIKHQ DI DMJIKHQ DMJIKHQ DN BsAb cG7-MICA DMJIKHQ MI TTCTYNP DMJIKHQ MN Small cell lung carcinoma cluster 4 antigen (CD24) DMJIKHQ MT DTT DMJIKHQ RN Targeting CD24 for treatment of colorectal and pancreatic cancer by monoclonal antibodies or small interfering RNA. Cancer Res. 2008 Apr 15;68(8):2803-12. DMJIKHQ RU https://pubmed.ncbi.nlm.nih.gov/217546303 DMNM63G DI DMNM63G DMNM63G DN BTP2 DMNM63G MI TTJ2HKA DMNM63G MN Long transient receptor potential channel 4 (TRPM4) DMNM63G MT DTT DMNM63G MA Activator DMNM63G RN A pyrazole derivative potently inhibits lymphocyte Ca2+ influx and cytokine production by facilitating transient receptor potential melastatin 4 ch... Mol Pharmacol. 2006 Apr;69(4):1413-20. DMNM63G RU https://pubmed.ncbi.nlm.nih.gov/16407466 DMNM63G DI DMNM63G DMNM63G DN BTP2 DMNM63G MI TTNVC34 DMNM63G MN Short transient receptor potential channel 3 (TRPC3) DMNM63G MT DTT DMNM63G MA Blocker (channel blocker) DMNM63G RN A functional link between store-operated and TRPC channels revealed by the 3,5-bis(trifluoromethyl)pyrazole derivative, BTP2. J Biol Chem. 2005 Mar 25;280(12):10997-1006. DMNM63G RU https://pubmed.ncbi.nlm.nih.gov/15647288 DMNM63G DI DMNM63G DMNM63G DN BTP2 DMNM63G MI TT32NQ1 DMNM63G MN Short transient receptor potential channel 5 (TRPC5) DMNM63G MT DTT DMNM63G MA Blocker (channel blocker) DMNM63G RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 490). DMNM63G RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=490 DMGFY4X DI DMGFY4X DMGFY4X DN BUDDLEDIN A DMGFY4X MI TT2J34L DMGFY4X MN Arachidonate 5-lipoxygenase (5-LOX) DMGFY4X MT DTT DMGFY4X MA Inhibitor DMGFY4X RN Novel and known constituents from Buddleja species and their activity against leukocyte eicosanoid generation. J Nat Prod. 1999 Sep;62(9):1241-5. DMGFY4X RU https://pubmed.ncbi.nlm.nih.gov/10514305 DMQVL2U DI DMQVL2U DMQVL2U DN BUDLEIN A DMQVL2U MI TTSXVID DMQVL2U MN Nuclear factor NF-kappa-B (NFKB) DMQVL2U MT DTT DMQVL2U MA Inhibitor DMQVL2U RN Quantitative structure-activity relationship of sesquiterpene lactones as inhibitors of the transcription factor NF-kappaB. J Med Chem. 2004 Nov 18;47(24):6042-54. DMQVL2U RU https://pubmed.ncbi.nlm.nih.gov/15537359 DM1D47I DI DM1D47I DM1D47I DN BU-E 47 DM1D47I MI TTTIBOJ DM1D47I MN Histamine H1 receptor (H1R) DM1D47I MT DTT DM1D47I MA Antagonist DM1D47I RN Multiple differences in agonist and antagonist pharmacology between human and guinea pig histamine H1-receptor. J Pharmacol Exp Ther. 2003 Jun;305(3):1104-15. DM1D47I RU https://pubmed.ncbi.nlm.nih.gov/12626648 DMD1SY9 DI DMD1SY9 DMD1SY9 DN bufotenine DMD1SY9 MI TT6MSOK DMD1SY9 MN 5-HT 1D receptor (HTR1D) DMD1SY9 MT DTT DMD1SY9 MA Antagonist DMD1SY9 RN Alniditan, a new 5-hydroxytryptamine1D agonist and migraine-abortive agent: ligand-binding properties of human 5-hydroxytryptamine1D alpha, human 5-hydroxytryptamine1D beta, and calf 5-hydroxytryptamine1D receptors investigated with [3H]5-hydroxytryptamine and [3H]alniditan. Mol Pharmacol. 1996 Dec;50(6):1567-80. DMD1SY9 RU https://pubmed.ncbi.nlm.nih.gov/8967979 DMD1SY9 DI DMD1SY9 DMD1SY9 DN bufotenine DMD1SY9 MI TTJQOD7 DMD1SY9 MN 5-HT 2A receptor (HTR2A) DMD1SY9 MT DTT DMD1SY9 MA Antagonist DMD1SY9 RN Mapping the binding site pocket of the serotonin 5-Hydroxytryptamine2A receptor. Ser3.36(159) provides a second interaction site for the protonated amine of serotonin but not of lysergic acid diethylamide or bufotenin. J Biol Chem. 1996 Jun 21;271(25):14672-5. DMD1SY9 RU https://pubmed.ncbi.nlm.nih.gov/8663249 DMD1SY9 DI DMD1SY9 DMD1SY9 DN bufotenine DMD1SY9 MI TTRUFDT DMD1SY9 MN 5-HT 5A receptor (HTR5A) DMD1SY9 MT DTT DMD1SY9 MA Antagonist DMD1SY9 RN Expression of functional mouse 5-HT5A serotonin receptor in the methylotrophic yeast Pichia pastoris: pharmacological characterization and localization. FEBS Lett. 1995 Dec 27;377(3):451-6. DMD1SY9 RU https://pubmed.ncbi.nlm.nih.gov/8549774 DMD1SY9 DI DMD1SY9 DMD1SY9 DN bufotenine DMD1SY9 MI TTJS8PY DMD1SY9 MN 5-HT 6 receptor (HTR6) DMD1SY9 MT DTT DMD1SY9 MA Antagonist DMD1SY9 RN Functional and radioligand binding characterization of rat 5-HT6 receptors stably expressed in HEK293 cells. Neuropharmacology. 1997 Apr-May;36(4-5):713-20. DMD1SY9 RU https://pubmed.ncbi.nlm.nih.gov/9225298 DMD1SY9 DI DMD1SY9 DMD1SY9 DN bufotenine DMD1SY9 MI TTO9X1H DMD1SY9 MN 5-HT 7 receptor (HTR7) DMD1SY9 MT DTT DMD1SY9 MA Agonist DMD1SY9 RN Molecular cloning of a mammalian serotonin receptor that activates adenylate cyclase. Mol Pharmacol. 1993 Aug;44(2):229-36. DMD1SY9 RU https://pubmed.ncbi.nlm.nih.gov/8394987 DM61F5W DI DM61F5W DM61F5W DN BUFROLIN DM61F5W MI TTHQENC DM61F5W MN Phosphodiesterase 1 (PDE1) DM61F5W MT DTT DM61F5W MA Inhibitor DM61F5W RN A new generation of phosphodiesterase inhibitors: multiple molecular forms of phosphodiesterase and the potential for drug selectivity. J Med Chem. 1985 May;28(5):537-45. DM61F5W RU https://pubmed.ncbi.nlm.nih.gov/2985781 DMWQ3RH DI DMWQ3RH DMWQ3RH DN bufrudin DMWQ3RH MI TT6L509 DMWQ3RH MN Coagulation factor IIa (F2) DMWQ3RH MT DTT DMWQ3RH MA Modulator DMWQ3RH RN Leech therapeutic applications.Indian J Pharm Sci.2013 Mar;75(2):127-37. DMWQ3RH RU https://www.ncbi.nlm.nih.gov/pubmed/24019559 DMJSC07 DI DMJSC07 DMJSC07 DN Bufuralol DMJSC07 MI DECB0K3 DMJSC07 MN Cytochrome P450 2D6 (CYP2D6) DMJSC07 MT DME DMJSC07 MA Metabolism DMJSC07 RN Cytochrome b5 is a major determinant of human cytochrome P450 CYP2D6 and CYP3A4 activity in vivo. Mol Pharmacol. 2015 Apr;87(4):733-9. DMJSC07 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=25657337 DMUT9IQ DI DMUT9IQ DMUT9IQ DN Bupranolol DMUT9IQ MI DECB0K3 DMUT9IQ MN Cytochrome P450 2D6 (CYP2D6) DMUT9IQ MT DME DMUT9IQ MA Metabolism DMUT9IQ RN Summary of information on human CYP enzymes: human P450 metabolism data. Drug Metab Rev. 2002 Feb-May;34(1-2):83-448. DMUT9IQ RU https://www.ncbi.nlm.nih.gov/pubmed/?term=11996015 DMZ2VYG DI DMZ2VYG DMZ2VYG DN burimamide DMZ2VYG MI TTQHJ1K DMZ2VYG MN Histamine H2 receptor (H2R) DMZ2VYG MT DTT DMZ2VYG MA Agonist DMZ2VYG RN Constitutive activity and structural instability of the wild-type human H2 receptor. J Neurochem. 1998 Aug;71(2):799-807. DMZ2VYG RU https://pubmed.ncbi.nlm.nih.gov/9681472 DMZ2VYG DI DMZ2VYG DMZ2VYG DN burimamide DMZ2VYG MI TT9JNIC DMZ2VYG MN Histamine H3 receptor (H3R) DMZ2VYG MT DTT DMZ2VYG MA Antagonist DMZ2VYG RN Cloning and pharmacological characterization of a fourth histamine receptor (H(4)) expressed in bone marrow. Mol Pharmacol. 2001 Mar;59(3):420-6. DMZ2VYG RU https://pubmed.ncbi.nlm.nih.gov/11179434 DMZ2VYG DI DMZ2VYG DMZ2VYG DN burimamide DMZ2VYG MI TTXJ178 DMZ2VYG MN Histamine H4 receptor (H4R) DMZ2VYG MT DTT DMZ2VYG MA Antagonist DMZ2VYG RN Comparison of human, mouse, rat, and guinea pig histamine H4 receptors reveals substantial pharmacological species variation. J Pharmacol Exp Ther. 2001 Oct;299(1):121-30. DMZ2VYG RU https://pubmed.ncbi.nlm.nih.gov/11561071 DMBO0WI DI DMBO0WI DMBO0WI DN Burnamine-17-O-3',4',5'-trimethoxybenzoate DMBO0WI MI TTF8JAT DMBO0WI MN SLC5A2 messenger RNA (SLC5A2 mRNA) DMBO0WI MT DTT DMBO0WI MA Inhibitor DMBO0WI RN Alstiphyllanines E-H, picraline and ajmaline-type alkaloids from Alstonia macrophylla inhibiting sodium glucose cotransporter. Bioorg Med Chem. 2010 Mar 15;18(6):2152-2158. DMBO0WI RU https://pubmed.ncbi.nlm.nih.gov/20189404 DMBO0WI DI DMBO0WI DMBO0WI DN Burnamine-17-O-3',4',5'-trimethoxybenzoate DMBO0WI MI TT2UE56 DMBO0WI MN Sodium/glucose cotransporter 1 (SGLT1) DMBO0WI MT DTT DMBO0WI MA Inhibitor DMBO0WI RN Alstiphyllanines E-H, picraline and ajmaline-type alkaloids from Alstonia macrophylla inhibiting sodium glucose cotransporter. Bioorg Med Chem. 2010 Mar 15;18(6):2152-2158. DMBO0WI RU https://pubmed.ncbi.nlm.nih.gov/20189404 DMJP0QT DI DMJP0QT DMJP0QT DN BURTTINONE DMJP0QT MI TTELIN2 DMJP0QT MN PTPN1 messenger RNA (PTPN1 mRNA) DMJP0QT MT DTT DMJP0QT MA Inhibitor DMJP0QT RN Flavanones from the stem bark of Erythrina abyssinica. Bioorg Med Chem. 2008 Dec 15;16(24):10356-62. DMJP0QT RU https://pubmed.ncbi.nlm.nih.gov/19008110 DMDC7MT DI DMDC7MT DMDC7MT DN Bu-RYYRIK-NH2 DMDC7MT MI TTNT7K8 DMDC7MT MN Nociceptin receptor (OPRL1) DMDC7MT MT DTT DMDC7MT MA Inhibitor DMDC7MT RN Designed modification of partial agonist of ORL1 nociceptin receptor for conversion into highly potent antagonist. Bioorg Med Chem. 2008 Mar 1;16(5):2635-44. DMDC7MT RU https://pubmed.ncbi.nlm.nih.gov/18068993 DMMHGIN DI DMMHGIN DMMHGIN DN But-3-enyl-trimethyl-ammonium bromide DMMHGIN MI TT1RS9F DMMHGIN MN Acetylcholinesterase (AChE) DMMHGIN MT DTT DMMHGIN MA Inhibitor DMMHGIN RN Structure-based alignment and comparative molecular field analysis of acetylcholinesterase inhibitors. J Med Chem. 1996 Dec 20;39(26):5064-71. DMMHGIN RU https://pubmed.ncbi.nlm.nih.gov/8978837 DMTAJP7 DI DMTAJP7 DMTAJP7 DN Butanoic acid DMTAJP7 MI DTI7UX6 DMTAJP7 MN Breast cancer resistance protein (ABCG2) DMTAJP7 MT DTP DMTAJP7 MA Substrate DMTAJP7 RN The short-chain fatty acid butyrate is a substrate of breast cancer resistance protein. Am J Physiol Cell Physiol. 2011 Nov;301(5):C984-94. DMTAJP7 RU https://doi.org/10.1152/ajpcell.00146.2011 DMTAJP7 DI DMTAJP7 DMTAJP7 DN Butanoic acid DMTAJP7 MI TTEB0GD DMTAJP7 MN Cholinesterase (BCHE) DMTAJP7 MT DTT DMTAJP7 MA Inhibitor DMTAJP7 RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMTAJP7 RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMTAJP7 DI DMTAJP7 DMTAJP7 DN Butanoic acid DMTAJP7 MI DT342ZG DMTAJP7 MN Monocarboxylate transporter 1 (SLC16A1) DMTAJP7 MT DTP DMTAJP7 MA Substrate DMTAJP7 RN Overview of the proton-coupled MCT (SLC16A) family of transporters: characterization, function and role in the transport of the drug of abuse gamma-hydroxybutyric acid. AAPS J. 2008 Jun;10(2):311-21. DMTAJP7 RU https://doi.org/10.1208/s12248-008-9035-6 DM5MZHP DI DM5MZHP DM5MZHP DN butaprost (free acid form) DM5MZHP MI TTOFYT1 DM5MZHP MN Prostacyclin receptor (PTGIR) DM5MZHP MT DTT DM5MZHP MA Agonist DM5MZHP RN The utilization of recombinant prostanoid receptors to determine the affinities and selectivities of prostaglandins and related analogs. Biochim Biophys Acta. 2000 Jan 17;1483(2):285-93. DM5MZHP RU https://pubmed.ncbi.nlm.nih.gov/10634944 DM5MZHP DI DM5MZHP DM5MZHP DN butaprost (free acid form) DM5MZHP MI TTNVEIR DM5MZHP MN Prostaglandin D2 receptor (PTGDR) DM5MZHP MT DTT DM5MZHP MA Agonist DM5MZHP RN The utilization of recombinant prostanoid receptors to determine the affinities and selectivities of prostaglandins and related analogs. Biochim Biophys Acta. 2000 Jan 17;1483(2):285-93. DM5MZHP RU https://pubmed.ncbi.nlm.nih.gov/10634944 DM5MZHP DI DM5MZHP DM5MZHP DN butaprost (free acid form) DM5MZHP MI TT1ZAVI DM5MZHP MN Prostaglandin E2 receptor EP2 (PTGER2) DM5MZHP MT DTT DM5MZHP MA Agonist DM5MZHP RN Importance of the extracellular domain for prostaglandin EP(2) receptor function. Mol Pharmacol. 1999 Sep;56(3):545-51. DM5MZHP RU https://pubmed.ncbi.nlm.nih.gov/10462542 DM5MZHP DI DM5MZHP DM5MZHP DN butaprost (free acid form) DM5MZHP MI TTPNGDE DM5MZHP MN Prostaglandin E2 receptor EP3 (PTGER3) DM5MZHP MT DTT DM5MZHP MA Agonist DM5MZHP RN The utilization of recombinant prostanoid receptors to determine the affinities and selectivities of prostaglandins and related analogs. Biochim Biophys Acta. 2000 Jan 17;1483(2):285-93. DM5MZHP RU https://pubmed.ncbi.nlm.nih.gov/10634944 DM5MZHP DI DM5MZHP DM5MZHP DN butaprost (free acid form) DM5MZHP MI TT79WV3 DM5MZHP MN Prostaglandin E2 receptor EP4 (PTGER4) DM5MZHP MT DTT DM5MZHP MA Agonist DM5MZHP RN Molecular cloning and characterization of the four rat prostaglandin E2 prostanoid receptor subtypes. Eur J Pharmacol. 1997 Dec 11;340(2-3):227-41. DM5MZHP RU https://pubmed.ncbi.nlm.nih.gov/9537820 DM5MZHP DI DM5MZHP DM5MZHP DN butaprost (free acid form) DM5MZHP MI TT2O84V DM5MZHP MN Thromboxane A2 receptor (TBXA2R) DM5MZHP MT DTT DM5MZHP MA Agonist DM5MZHP RN The utilization of recombinant prostanoid receptors to determine the affinities and selectivities of prostaglandins and related analogs. Biochim Biophys Acta. 2000 Jan 17;1483(2):285-93. DM5MZHP RU https://pubmed.ncbi.nlm.nih.gov/10634944 DM8E54P DI DM8E54P DM8E54P DN BUTEIN DM8E54P MI TTL69WB DM8E54P MN Angiotensin-converting enzyme (ACE) DM8E54P MT DTT DM8E54P MA Inhibitor DM8E54P RN The synthesis and angiotensin converting enzyme (ACE) inhibitory activity of chalcones and their pyrazole derivatives. Bioorg Med Chem Lett. 2010 Mar 15;20(6):1990-3. DM8E54P RU https://pubmed.ncbi.nlm.nih.gov/20167484 DM8E54P DI DM8E54P DM8E54P DN BUTEIN DM8E54P MI TTNX2CS DM8E54P MN Plasmodium Enoyl-ACP reductase (Malaria fabI) DM8E54P MT DTT DM8E54P MA Inhibitor DM8E54P RN Green tea catechins potentiate triclosan binding to enoyl-ACP reductase from Plasmodium falciparum (PfENR). J Med Chem. 2007 Feb 22;50(4):765-75. DM8E54P RU https://pubmed.ncbi.nlm.nih.gov/17263522 DMJ46CB DI DMJ46CB DMJ46CB DN Buthionine sulfoximine DMJ46CB MI TTNFESW DMJ46CB MN Glutamate--cysteine ligase modifier (GCLM) DMJ46CB MT DTT DMJ46CB MA Inhibitor DMJ46CB RN Novel molecular targets for antimalarial chemotherapy. Int J Antimicrob Agents. 2007 Jul;30(1):4-10. DMJ46CB RU https://pubmed.ncbi.nlm.nih.gov/17339102 DMR6GJK DI DMR6GJK DMR6GJK DN Butirosin B DMR6GJK MI TT38DW5 DMR6GJK MN Bacterial 16S ribosomal RNA (Bact 16S rRNA) DMR6GJK MT DTT DMR6GJK MA Inhibitor DMR6GJK RN RNA as a target for small molecules. Curr Opin Chem Biol. 2000 Dec;4(6):678-86. DMR6GJK RU https://pubmed.ncbi.nlm.nih.gov/11102874 DM82KPQ DI DM82KPQ DM82KPQ DN BUTORPHAN DM82KPQ MI TT27RFC DM82KPQ MN Opioid receptor delta (OPRD1) DM82KPQ MT DTT DM82KPQ MA Inhibitor DM82KPQ RN Effect of linker substitution on the binding of butorphan univalent and bivalent ligands to opioid receptors. Bioorg Med Chem Lett. 2010 Mar 1;20(5):1507-9. DM82KPQ RU https://pubmed.ncbi.nlm.nih.gov/20144870 DM82KPQ DI DM82KPQ DM82KPQ DN BUTORPHAN DM82KPQ MI TTQW87Y DM82KPQ MN Opioid receptor kappa (OPRK1) DM82KPQ MT DTT DM82KPQ MA Inhibitor DM82KPQ RN Synthesis and opioid receptor affinity of morphinan and benzomorphan derivatives: mixed kappa agonists and mu agonists/antagonists as potential pha... J Med Chem. 2000 Jan 13;43(1):114-22. DM82KPQ RU https://pubmed.ncbi.nlm.nih.gov/10633042 DM82KPQ DI DM82KPQ DM82KPQ DN BUTORPHAN DM82KPQ MI TTKWM86 DM82KPQ MN Opioid receptor mu (MOP) DM82KPQ MT DTT DM82KPQ MA Inhibitor DM82KPQ RN Synthesis and opioid receptor affinity of morphinan and benzomorphan derivatives: mixed kappa agonists and mu agonists/antagonists as potential pha... J Med Chem. 2000 Jan 13;43(1):114-22. DM82KPQ RU https://pubmed.ncbi.nlm.nih.gov/10633042 DM7XN2J DI DM7XN2J DM7XN2J DN Butoxamine DM7XN2J MI TT2CJVK DM7XN2J MN Adrenergic receptor beta-2 (ADRB2) DM7XN2J MT DTT DM7XN2J MA Antagonist DM7XN2J RN Partial agonistic effects of carteolol on atypical beta-adrenoceptors in the guinea pig gastric fundus. Jpn J Pharmacol. 2000 Nov;84(3):287-92. DM7XN2J RU https://pubmed.ncbi.nlm.nih.gov/11138729 DMGHEQV DI DMGHEQV DMGHEQV DN Butyl 10H-phenothiazine-10-carboxylate DMGHEQV MI TTEB0GD DMGHEQV MN Cholinesterase (BCHE) DMGHEQV MT DTT DMGHEQV MA Inhibitor DMGHEQV RN Carbamates with differential mechanism of inhibition toward acetylcholinesterase and butyrylcholinesterase. J Med Chem. 2008 Jul 24;51(14):4200-12. DMGHEQV RU https://pubmed.ncbi.nlm.nih.gov/18570368 DM1CX9Y DI DM1CX9Y DM1CX9Y DN Butyl-indol-1-yl-pyridin-4-yl-amine DM1CX9Y MI TTWG9A4 DM1CX9Y MN Adrenergic receptor alpha-2A (ADRA2A) DM1CX9Y MT DTT DM1CX9Y MA Inhibitor DM1CX9Y RN Synthesis and structure-activity relationships of N-propyl-N-(4-pyridinyl)-1H-indol-1-amine (besipirdine) and related analogs as potential therapeu... J Med Chem. 1996 Jan 19;39(2):570-81. DM1CX9Y RU https://pubmed.ncbi.nlm.nih.gov/8558529 DM1CX9Y DI DM1CX9Y DM1CX9Y DN Butyl-indol-1-yl-pyridin-4-yl-amine DM1CX9Y MI TTWM4TY DM1CX9Y MN Adrenergic receptor alpha-2B (ADRA2B) DM1CX9Y MT DTT DM1CX9Y MA Inhibitor DM1CX9Y RN Synthesis and structure-activity relationships of N-propyl-N-(4-pyridinyl)-1H-indol-1-amine (besipirdine) and related analogs as potential therapeu... J Med Chem. 1996 Jan 19;39(2):570-81. DM1CX9Y RU https://pubmed.ncbi.nlm.nih.gov/8558529 DM1CX9Y DI DM1CX9Y DM1CX9Y DN Butyl-indol-1-yl-pyridin-4-yl-amine DM1CX9Y MI TT2NUT5 DM1CX9Y MN Adrenergic receptor alpha-2C (ADRA2C) DM1CX9Y MT DTT DM1CX9Y MA Inhibitor DM1CX9Y RN Synthesis and structure-activity relationships of N-propyl-N-(4-pyridinyl)-1H-indol-1-amine (besipirdine) and related analogs as potential therapeu... J Med Chem. 1996 Jan 19;39(2):570-81. DM1CX9Y RU https://pubmed.ncbi.nlm.nih.gov/8558529 DMJUTWG DI DMJUTWG DMJUTWG DN Butyl-methyl-prop-2-ynyl-amine hydrochloride DMJUTWG MI TTGP7BY DMJUTWG MN Monoamine oxidase type B (MAO-B) DMJUTWG MT DTT DMJUTWG MA Inhibitor DMJUTWG RN Aliphatic propargylamines: potent, selective, irreversible monoamine oxidase B inhibitors. J Med Chem. 1992 Oct 2;35(20):3705-13. DMJUTWG RU https://pubmed.ncbi.nlm.nih.gov/1433183 DMF5D1N DI DMF5D1N DMF5D1N DN Butylphosphonate DMF5D1N MI TT3GKN5 DMF5D1N MN Lipase unspecific (LIP) DMF5D1N MT DTT DMF5D1N MA Inhibitor DMF5D1N RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMF5D1N RU https://pubmed.ncbi.nlm.nih.gov/17139284 DM9X2FV DI DM9X2FV DM9X2FV DN Butyrfentanyl DM9X2FV MI DECB0K3 DM9X2FV MN Cytochrome P450 2D6 (CYP2D6) DM9X2FV MT DME DM9X2FV MA Metabolism DM9X2FV RN Studies on the metabolism of the fentanyl-derived designer drug butyrfentanyl in human in vitro liver preparations and authentic human samples using liquid chromatography-high resolution mass spectrometry (LC-HRMS). Drug Test Anal. 2017 Jul;9(7):1085-1092. DM9X2FV RU https://www.ncbi.nlm.nih.gov/pubmed/?term=27736030 DM9X2FV DI DM9X2FV DM9X2FV DN Butyrfentanyl DM9X2FV MI DE4LYSA DM9X2FV MN Cytochrome P450 3A4 (CYP3A4) DM9X2FV MT DME DM9X2FV MA Metabolism DM9X2FV RN Metabolism of butyrylfentanyl in fresh human hepatocytes: chemical synthesis of authentic metabolite standards for definitive identification. Biol Pharm Bull. 2019;42(4):623-630. DM9X2FV RU https://www.ncbi.nlm.nih.gov/pubmed/?term=30930421 DMOBYVL DI DMOBYVL DMOBYVL DN Butyrylthiocholine DMOBYVL MI TTEB0GD DMOBYVL MN Cholinesterase (BCHE) DMOBYVL MT DTT DMOBYVL MA Inhibitor DMOBYVL RN DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Nucleic Acids Res. 2011 Jan;39(Database issue):D1035-41. DMOBYVL RU https://pubmed.ncbi.nlm.nih.gov/21059682 DMDTV7A DI DMDTV7A DMDTV7A DN BV-6 DMDTV7A MI TTQ5LRD DMDTV7A MN Cellular inhibitor of apoptosis 1 (BIRC2) DMDTV7A MT DTT DMDTV7A MA Inhibitor DMDTV7A RN IAP antagonists induce autoubiquitination of c-IAPs, NF-kappaB activation, and TNFalpha-dependent apoptosis. Cell. 2007 Nov 16;131(4):669-81. DMDTV7A RU https://pubmed.ncbi.nlm.nih.gov/18022362 DMDTV7A DI DMDTV7A DMDTV7A DN BV-6 DMDTV7A MI TTK3WBU DMDTV7A MN XIAP messenger RNA (XIAP mRNA) DMDTV7A MT DTT DMDTV7A MA Inhibitor DMDTV7A RN IAP antagonists induce autoubiquitination of c-IAPs, NF-kappaB activation, and TNFalpha-dependent apoptosis. Cell. 2007 Nov 16;131(4):669-81. DMDTV7A RU https://pubmed.ncbi.nlm.nih.gov/18022362 DM10UHA DI DM10UHA DM10UHA DN BVB-808 DM10UHA MI TTRMX3V DM10UHA MN Janus kinase 2 (JAK-2) DM10UHA MT DTT DM10UHA MA Inhibitor DM10UHA RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2048). DM10UHA RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2048 DMI1H3Y DI DMI1H3Y DMI1H3Y DN BVDU-MP DMI1H3Y MI TTP3QRF DMI1H3Y MN Thymidine kinase 1 (TK1) DMI1H3Y MT DTT DMI1H3Y MA Inhibitor DMI1H3Y RN Crystal structure of varicella zoster virus thymidine kinase. J Biol Chem. 2003 Jul 4;278(27):24680-7. DMI1H3Y RU https://pubmed.ncbi.nlm.nih.gov/12686543 DM8N7BA DI DM8N7BA DM8N7BA DN BVT 933 DM8N7BA MI TTWJBZ5 DM8N7BA MN 5-HT 2C receptor (HTR2C) DM8N7BA MT DTT DM8N7BA MA Antagonist DM8N7BA RN Obesity: pathophysiology and clinical management. Curr Med Chem. 2009;16(4):506-21. DM8N7BA RU https://pubmed.ncbi.nlm.nih.gov/19199918 DMULZOP DI DMULZOP DMULZOP DN BVT173187 DMULZOP MI TT5Y4EM DMULZOP MN N-formyl peptide receptor (FPR1) DMULZOP MT DTT DMULZOP MA Antagonist DMULZOP RN A non-peptide receptor inhibitor with selectivity for one of the neutrophil formyl peptide receptors, FPR 1. Biochem Pharmacol. 2012 Jun 15;83(12):1655-62. DMULZOP RU https://pubmed.ncbi.nlm.nih.gov/22410002 DMAVDNU DI DMAVDNU DMAVDNU DN BVX-20-CD20 DMAVDNU MI TTUE541 DMAVDNU MN Leukocyte surface antigen Leu-16 (CD20) DMAVDNU MT DTT DMAVDNU RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2628). DMAVDNU RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2628 DMA0FO5 DI DMA0FO5 DMA0FO5 DN BW 245C DMA0FO5 MI TTNVEIR DMA0FO5 MN Prostaglandin D2 receptor (PTGDR) DMA0FO5 MT DTT DMA0FO5 MA Agonist DMA0FO5 RN Ligand binding specificities of the eight types and subtypes of the mouse prostanoid receptors expressed in Chinese hamster ovary cells. Br J Pharmacol. 1997 Sep;122(2):217-24. DMA0FO5 RU https://pubmed.ncbi.nlm.nih.gov/9313928 DMNSLGC DI DMNSLGC DMNSLGC DN BW A360C DMNSLGC MI TT2J34L DMNSLGC MN Arachidonate 5-lipoxygenase (5-LOX) DMNSLGC MT DTT DMNSLGC MA Inhibitor DMNSLGC RN Hydroxamic acids and hydroxyureas as novel, selective 5-lipoxygenase inhibitors for possible use in asthma. Agents Actions Suppl. 1991;34:189-99. DMNSLGC RU https://pubmed.ncbi.nlm.nih.gov/1793063 DMHQP84 DI DMHQP84 DMHQP84 DN BW B218C DMHQP84 MI TT2J34L DMHQP84 MN Arachidonate 5-lipoxygenase (5-LOX) DMHQP84 MT DTT DMHQP84 MA Inhibitor DMHQP84 RN Hydroxamic acids and hydroxyureas as novel, selective 5-lipoxygenase inhibitors for possible use in asthma. Agents Actions Suppl. 1991;34:189-99. DMHQP84 RU https://pubmed.ncbi.nlm.nih.gov/1793063 DMFKXMT DI DMFKXMT DMFKXMT DN BW-202W92 DMFKXMT MI TTRK8B9 DMFKXMT MN Sodium channel unspecific (NaC) DMFKXMT MT DTT DMFKXMT MA Inhibitor DMFKXMT RN Oxadiazolylindazole sodium channel modulators are neuroprotective toward hippocampal neurones. J Med Chem. 2009 May 14;52(9):2694-707. DMFKXMT RU https://pubmed.ncbi.nlm.nih.gov/19341281 DMFKXMT DI DMFKXMT DMFKXMT DN BW-202W92 DMFKXMT MI TTAXZ0K DMFKXMT MN Voltage-gated sodium channel alpha Nav1.3 (SCN3A) DMFKXMT MT DTT DMFKXMT MA Inhibitor DMFKXMT RN Oxadiazolylindazole sodium channel modulators are neuroprotective toward hippocampal neurones. J Med Chem. 2009 May 14;52(9):2694-707. DMFKXMT RU https://pubmed.ncbi.nlm.nih.gov/19341281 DMFKXMT DI DMFKXMT DMFKXMT DN BW-202W92 DMFKXMT MI TT84DRB DMFKXMT MN Voltage-gated sodium channel alpha Nav1.4 (SCN4A) DMFKXMT MT DTT DMFKXMT MA Inhibitor DMFKXMT RN Oxadiazolylindazole sodium channel modulators are neuroprotective toward hippocampal neurones. J Med Chem. 2009 May 14;52(9):2694-707. DMFKXMT RU https://pubmed.ncbi.nlm.nih.gov/19341281 DMFKXMT DI DMFKXMT DMFKXMT DN BW-202W92 DMFKXMT MI TT90XZ8 DMFKXMT MN Voltage-gated sodium channel alpha Nav1.8 (SCN10A) DMFKXMT MT DTT DMFKXMT MA Inhibitor DMFKXMT RN Oxadiazolylindazole sodium channel modulators are neuroprotective toward hippocampal neurones. J Med Chem. 2009 May 14;52(9):2694-707. DMFKXMT RU https://pubmed.ncbi.nlm.nih.gov/19341281 DMQ3AC0 DI DMQ3AC0 DMQ3AC0 DN BW284C51 DMQ3AC0 MI TT1RS9F DMQ3AC0 MN Acetylcholinesterase (AChE) DMQ3AC0 MT DTT DMQ3AC0 MA Inhibitor DMQ3AC0 RN Cholinesterases: new roles in brain function and in Alzheimer's disease. Neurochem Res. 2003 Apr;28(3-4):515-22. DMQ3AC0 RU https://pubmed.ncbi.nlm.nih.gov/12675140 DME15JU DI DME15JU DME15JU DN BW723C86 DME15JU MI TTJQOD7 DME15JU MN 5-HT 2A receptor (HTR2A) DME15JU MT DTT DME15JU MA Agonist DME15JU RN Pharmacological characterisation of the agonist radioligand binding site of 5-HT(2A), 5-HT(2B) and 5-HT(2C) receptors. Naunyn Schmiedebergs Arch Pharmacol. 2004 Aug;370(2):114-23. DME15JU RU https://pubmed.ncbi.nlm.nih.gov/15322733 DME15JU DI DME15JU DME15JU DN BW723C86 DME15JU MI TT0K1SC DME15JU MN 5-HT 2B receptor (HTR2B) DME15JU MT DTT DME15JU MA Agonist DME15JU RN Agonist actions of dihydroergotamine at 5-HT2B and 5-HT2C receptors and their possible relevance to antimigraine efficacy. Br J Pharmacol. 2003 Sep;140(2):277-84. DME15JU RU https://pubmed.ncbi.nlm.nih.gov/12970106 DME15JU DI DME15JU DME15JU DN BW723C86 DME15JU MI TTWJBZ5 DME15JU MN 5-HT 2C receptor (HTR2C) DME15JU MT DTT DME15JU MA Agonist DME15JU RN Agonist actions of dihydroergotamine at 5-HT2B and 5-HT2C receptors and their possible relevance to antimigraine efficacy. Br J Pharmacol. 2003 Sep;140(2):277-84. DME15JU RU https://pubmed.ncbi.nlm.nih.gov/12970106 DMM2WPH DI DMM2WPH DMM2WPH DN BW-858C DMM2WPH MI TT2J34L DMM2WPH MN Arachidonate 5-lipoxygenase (5-LOX) DMM2WPH MT DTT DMM2WPH MA Modulator DMM2WPH RN Effect of BW B70C, a novel inhibitor of arachidonic acid 5-lipoxygenase, on allergen-induced bronchoconstriction and late-phase lung eosinophil accumulation in sensitised guinea-pigs. Agents Actions.1993 Jan;38(1-2):8-18. DMM2WPH RU https://pubmed.ncbi.nlm.nih.gov/8480540 DM7SNU0 DI DM7SNU0 DM7SNU0 DN BW-A137C DM7SNU0 MI TT2J34L DM7SNU0 MN Arachidonate 5-lipoxygenase (5-LOX) DM7SNU0 MT DTT DM7SNU0 MA Modulator DM7SNU0 RN Selective inhibition of arachidonate 5-lipoxygenase by novel acetohydroxamic acids: effects on bronchial anaphylaxis in anaesthetized guinea-pigs. Br J Pharmacol. 1988 Jun;94(2):540-6. DM7SNU0 RU https://www.ncbi.nlm.nih.gov/pubmed/3395791 DMU9LQW DI DMU9LQW DMU9LQW DN BWA868C DMU9LQW MI TTNVEIR DMU9LQW MN Prostaglandin D2 receptor (PTGDR) DMU9LQW MT DTT DMU9LQW MA Antagonist DMU9LQW RN Pharmacology and autoradiography of human DP prostanoid receptors using [(3)H]-BWA868C, a DP receptor-selective antagonist radioligand. Br J Pharmacol. 2000 Nov;131(6):1025-38. DMU9LQW RU https://pubmed.ncbi.nlm.nih.gov/11082108 DMA2B1C DI DMA2B1C DMA2B1C DN BX 048 DMA2B1C MI TTZ1DT0 DMA2B1C MN P2Y purinoceptor 12 (P2RY12) DMA2B1C MT DTT DMA2B1C MA Antagonist DMA2B1C RN Novel P2Y12 adenosine diphosphate receptor antagonists for inhibition of platelet aggregation (II): pharmacodynamic and pharmacokinetic characterization. Thromb Res. 2008;122(4):533-40. DMA2B1C RU https://pubmed.ncbi.nlm.nih.gov/18539312 DM5CGXB DI DM5CGXB DM5CGXB DN BX 471 DM5CGXB MI TTC24WT DM5CGXB MN C-C chemokine receptor type 1 (CCR1) DM5CGXB MT DTT DM5CGXB MA Antagonist DM5CGXB RN Identification and characterization of a potent, selective, and orally active antagonist of the CC chemokine receptor-1. J Biol Chem. 2000 Jun 23;275(25):19000-8. DM5CGXB RU https://pubmed.ncbi.nlm.nih.gov/10748002 DMBKVN9 DI DMBKVN9 DMBKVN9 DN BX 667 DMBKVN9 MI TTZ1DT0 DMBKVN9 MN P2Y purinoceptor 12 (P2RY12) DMBKVN9 MT DTT DMBKVN9 MA Antagonist DMBKVN9 RN Novel P2Y12 adenosine diphosphate receptor antagonists for inhibition of platelet aggregation (II): pharmacodynamic and pharmacokinetic characterization. Thromb Res. 2008;122(4):533-40. DMBKVN9 RU https://pubmed.ncbi.nlm.nih.gov/18539312 DMGK7U5 DI DMGK7U5 DMGK7U5 DN BX-201 DMGK7U5 MI TTYMGWX DMGK7U5 MN PDK-1 messenger RNA (PDK-1 mRNA) DMGK7U5 MT DTT DMGK7U5 MA Inhibitor DMGK7U5 RN Indolinone based phosphoinositide-dependent kinase-1 (PDK1) inhibitors. Part 1: design, synthesis and biological activity. Bioorg Med Chem Lett. 2007 Jul 15;17(14):3814-8. DMGK7U5 RU https://pubmed.ncbi.nlm.nih.gov/17531483 DMBQIEF DI DMBQIEF DMBQIEF DN BX-517 DMBQIEF MI TTYMGWX DMBQIEF MN PDK-1 messenger RNA (PDK-1 mRNA) DMBQIEF MT DTT DMBQIEF MA Inhibitor DMBQIEF RN Indolinone based phosphoinositide-dependent kinase-1 (PDK1) inhibitors. Part 1: design, synthesis and biological activity. Bioorg Med Chem Lett. 2007 Jul 15;17(14):3814-8. DMBQIEF RU https://pubmed.ncbi.nlm.nih.gov/17531483 DMBQIEF DI DMBQIEF DMBQIEF DN BX-517 DMBQIEF MI TTWTSCV DMBQIEF MN RAC-alpha serine/threonine-protein kinase (AKT1) DMBQIEF MT DTT DMBQIEF MA Inhibitor DMBQIEF RN Indolinone based phosphoinositide-dependent kinase-1 (PDK1) inhibitors. Part 1: design, synthesis and biological activity. Bioorg Med Chem Lett. 2007 Jul 15;17(14):3814-8. DMBQIEF RU https://pubmed.ncbi.nlm.nih.gov/17531483 DMRIMLJ DI DMRIMLJ DMRIMLJ DN BX-795 DMRIMLJ MI TTTU902 DMRIMLJ MN Checkpoint kinase-1 (CHK1) DMRIMLJ MT DTT DMRIMLJ MA Inhibitor DMRIMLJ RN Novel small molecule inhibitors of 3-phosphoinositide-dependent kinase-1. J Biol Chem. 2005 May 20;280(20):19867-74. DMRIMLJ RU https://pubmed.ncbi.nlm.nih.gov/15772071 DMRIMLJ DI DMRIMLJ DMRIMLJ DN BX-795 DMRIMLJ MI TT7HF4W DMRIMLJ MN Cyclin-dependent kinase 2 (CDK2) DMRIMLJ MT DTT DMRIMLJ MA Inhibitor DMRIMLJ RN Novel small molecule inhibitors of 3-phosphoinositide-dependent kinase-1. J Biol Chem. 2005 May 20;280(20):19867-74. DMRIMLJ RU https://pubmed.ncbi.nlm.nih.gov/15772071 DMRIMLJ DI DMRIMLJ DMRIMLJ DN BX-795 DMRIMLJ MI TTYVI76 DMRIMLJ MN Fungal Protein kinase A (Fung ypkA) DMRIMLJ MT DTT DMRIMLJ MA Inhibitor DMRIMLJ RN Novel small molecule inhibitors of 3-phosphoinositide-dependent kinase-1. J Biol Chem. 2005 May 20;280(20):19867-74. DMRIMLJ RU https://pubmed.ncbi.nlm.nih.gov/15772071 DMRIMLJ DI DMRIMLJ DMRIMLJ DN BX-795 DMRIMLJ MI TTRSMW9 DMRIMLJ MN Glycogen synthase kinase-3 beta (GSK-3B) DMRIMLJ MT DTT DMRIMLJ MA Inhibitor DMRIMLJ RN Novel small molecule inhibitors of 3-phosphoinositide-dependent kinase-1. J Biol Chem. 2005 May 20;280(20):19867-74. DMRIMLJ RU https://pubmed.ncbi.nlm.nih.gov/15772071 DMRIMLJ DI DMRIMLJ DMRIMLJ DN BX-795 DMRIMLJ MI TT9QBI6 DMRIMLJ MN Phosphoinositide dependent protein kinase-1 (PDPK1) DMRIMLJ MT DTT DMRIMLJ MA Inhibitor DMRIMLJ RN Novel small molecule inhibitors of 3-phosphoinositide-dependent kinase-1. J Biol Chem. 2005 May 20;280(20):19867-74. DMRIMLJ RU https://pubmed.ncbi.nlm.nih.gov/15772071 DMRIMLJ DI DMRIMLJ DMRIMLJ DN BX-795 DMRIMLJ MI TTUTJGQ DMRIMLJ MN Vascular endothelial growth factor receptor 2 (KDR) DMRIMLJ MT DTT DMRIMLJ MA Inhibitor DMRIMLJ RN Novel small molecule inhibitors of 3-phosphoinositide-dependent kinase-1. J Biol Chem. 2005 May 20;280(20):19867-74. DMRIMLJ RU https://pubmed.ncbi.nlm.nih.gov/15772071 DMZA45C DI DMZA45C DMZA45C DN BX-912 DMZA45C MI TTTU902 DMZA45C MN Checkpoint kinase-1 (CHK1) DMZA45C MT DTT DMZA45C MA Inhibitor DMZA45C RN Novel small molecule inhibitors of 3-phosphoinositide-dependent kinase-1. J Biol Chem. 2005 May 20;280(20):19867-74. DMZA45C RU https://pubmed.ncbi.nlm.nih.gov/15772071 DMZA45C DI DMZA45C DMZA45C DN BX-912 DMZA45C MI TT7HF4W DMZA45C MN Cyclin-dependent kinase 2 (CDK2) DMZA45C MT DTT DMZA45C MA Inhibitor DMZA45C RN Novel small molecule inhibitors of 3-phosphoinositide-dependent kinase-1. J Biol Chem. 2005 May 20;280(20):19867-74. DMZA45C RU https://pubmed.ncbi.nlm.nih.gov/15772071 DMZA45C DI DMZA45C DMZA45C DN BX-912 DMZA45C MI TTYVI76 DMZA45C MN Fungal Protein kinase A (Fung ypkA) DMZA45C MT DTT DMZA45C MA Inhibitor DMZA45C RN Novel small molecule inhibitors of 3-phosphoinositide-dependent kinase-1. J Biol Chem. 2005 May 20;280(20):19867-74. DMZA45C RU https://pubmed.ncbi.nlm.nih.gov/15772071 DMZA45C DI DMZA45C DMZA45C DN BX-912 DMZA45C MI TTRSMW9 DMZA45C MN Glycogen synthase kinase-3 beta (GSK-3B) DMZA45C MT DTT DMZA45C MA Inhibitor DMZA45C RN Novel small molecule inhibitors of 3-phosphoinositide-dependent kinase-1. J Biol Chem. 2005 May 20;280(20):19867-74. DMZA45C RU https://pubmed.ncbi.nlm.nih.gov/15772071 DMZA45C DI DMZA45C DMZA45C DN BX-912 DMZA45C MI TT9QBI6 DMZA45C MN Phosphoinositide dependent protein kinase-1 (PDPK1) DMZA45C MT DTT DMZA45C MA Inhibitor DMZA45C RN Novel small molecule inhibitors of 3-phosphoinositide-dependent kinase-1. J Biol Chem. 2005 May 20;280(20):19867-74. DMZA45C RU https://pubmed.ncbi.nlm.nih.gov/15772071 DMZA45C DI DMZA45C DMZA45C DN BX-912 DMZA45C MI TTUTJGQ DMZA45C MN Vascular endothelial growth factor receptor 2 (KDR) DMZA45C MT DTT DMZA45C MA Inhibitor DMZA45C RN Novel small molecule inhibitors of 3-phosphoinositide-dependent kinase-1. J Biol Chem. 2005 May 20;280(20):19867-74. DMZA45C RU https://pubmed.ncbi.nlm.nih.gov/15772071 DMAWMDN DI DMAWMDN DMAWMDN DN BYK-191023 DMAWMDN MI TTF10I9 DMAWMDN MN Nitric-oxide synthase inducible (NOS2) DMAWMDN MT DTT DMAWMDN MA Inhibitor DMAWMDN RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1250). DMAWMDN RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1250 DMN5X17 DI DMN5X17 DMN5X17 DN BZ3 DMN5X17 MI TTVDSZ0 DMN5X17 MN Poly [ADP-ribose] polymerase 1 (PARP1) DMN5X17 MT DTT DMN5X17 MA Inhibitor DMN5X17 RN Identification of potent nontoxic poly(ADP-Ribose) polymerase-1 inhibitors: chemopotentiation and pharmacological studies. Clin Cancer Res. 2003 Jul;9(7):2711-8. DMN5X17 RU https://pubmed.ncbi.nlm.nih.gov/12855651 DMRXPFM DI DMRXPFM DMRXPFM DN BZ5 DMRXPFM MI TTVDSZ0 DMRXPFM MN Poly [ADP-ribose] polymerase 1 (PARP1) DMRXPFM MT DTT DMRXPFM MA Inhibitor DMRXPFM RN Identification of potent nontoxic poly(ADP-Ribose) polymerase-1 inhibitors: chemopotentiation and pharmacological studies. Clin Cancer Res. 2003 Jul;9(7):2711-8. DMRXPFM RU https://pubmed.ncbi.nlm.nih.gov/12855651 DMF8UWE DI DMF8UWE DMF8UWE DN BZ6 DMF8UWE MI TTVDSZ0 DMF8UWE MN Poly [ADP-ribose] polymerase 1 (PARP1) DMF8UWE MT DTT DMF8UWE MA Inhibitor DMF8UWE RN Identification of potent nontoxic poly(ADP-Ribose) polymerase-1 inhibitors: chemopotentiation and pharmacological studies. Clin Cancer Res. 2003 Jul;9(7):2711-8. DMF8UWE RU https://pubmed.ncbi.nlm.nih.gov/12855651 DM37GYA DI DM37GYA DM37GYA DN BzATP DM37GYA MI TTJW7B3 DM37GYA MN P2X purinoceptor 1 (P2RX1) DM37GYA MT DTT DM37GYA MA Agonist DM37GYA RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 478). DM37GYA RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=478 DM37GYA DI DM37GYA DM37GYA DN BzATP DM37GYA MI TT2THBD DM37GYA MN P2X purinoceptor 3 (P2RX3) DM37GYA MT DTT DM37GYA MA Agonist DM37GYA RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 480). DM37GYA RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=480 DM37GYA DI DM37GYA DM37GYA DN BzATP DM37GYA MI TTYXPCO DM37GYA MN P2Y purinoceptor 11 (P2RY11) DM37GYA MT DTT DM37GYA MA Agonist DM37GYA RN Pharmacological characterization of the human P2Y11 receptor. Br J Pharmacol. 1999 Nov;128(6):1199-206. DM37GYA RU https://pubmed.ncbi.nlm.nih.gov/10578132 DMUW87A DI DMUW87A DMUW87A DN Bz--RYYRIK-NH2 DMUW87A MI TTNT7K8 DMUW87A MN Nociceptin receptor (OPRL1) DMUW87A MT DTT DMUW87A MA Inhibitor DMUW87A RN Designed modification of partial agonist of ORL1 nociceptin receptor for conversion into highly potent antagonist. Bioorg Med Chem. 2008 Mar 1;16(5):2635-44. DMUW87A RU https://pubmed.ncbi.nlm.nih.gov/18068993 DMU13BY DI DMU13BY DMU13BY DN BzT-7 DMU13BY MI TTRA6BO DMU13BY MN Bromodomain-containing protein 4 (BRD4) DMU13BY MT DTT DMU13BY MA Inhibitor DMU13BY RN Benzodiazepines and benzotriazepines as protein interaction inhibitors targeting bromodomains of the BET family. Bioorg Med Chem. 2012 Mar 15;20(6):1878-86. DMU13BY RU https://pubmed.ncbi.nlm.nih.gov/22137933 DMA0GSY DI DMA0GSY DMA0GSY DN BZYX DMA0GSY MI TT1RS9F DMA0GSY MN Acetylcholinesterase (AChE) DMA0GSY MT DTT DMA0GSY MA Inhibitor DMA0GSY RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2465). DMA0GSY RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2465 DMMPXHQ DI DMMPXHQ DMMPXHQ DN C-(1-Azido-Alpha-D-Glucopyranosyl) Formamide DMMPXHQ MI TTZHY6R DMMPXHQ MN Glycogen phosphorylase muscle form (GP) DMMPXHQ MT DTT DMMPXHQ MA Inhibitor DMMPXHQ RN DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Nucleic Acids Res. 2011 Jan;39(Database issue):D1035-41. DMMPXHQ RU https://pubmed.ncbi.nlm.nih.gov/21059682 DMDLK9G DI DMDLK9G DMDLK9G DN C-(1H-Indol-3-yl)-methylamine DMDLK9G MI TT3WG5C DMDLK9G MN Monoamine oxidase type A (MAO-A) DMDLK9G MT DTT DMDLK9G MA Inhibitor DMDLK9G RN Binding of beta-carbolines at imidazoline I2 receptors: a structure-affinity investigation. Bioorg Med Chem Lett. 2004 Feb 23;14(4):999-1002. DMDLK9G RU https://pubmed.ncbi.nlm.nih.gov/15013009 DMDLK9G DI DMDLK9G DMDLK9G DN C-(1H-Indol-3-yl)-methylamine DMDLK9G MI TTGP7BY DMDLK9G MN Monoamine oxidase type B (MAO-B) DMDLK9G MT DTT DMDLK9G MA Inhibitor DMDLK9G RN Binding of beta-carbolines at imidazoline I2 receptors: a structure-affinity investigation. Bioorg Med Chem Lett. 2004 Feb 23;14(4):999-1002. DMDLK9G RU https://pubmed.ncbi.nlm.nih.gov/15013009 DM3VF9M DI DM3VF9M DM3VF9M DN C-(1-Hydrogyl-Beta-D-Glucopyranosyl) Formamide DM3VF9M MI TTZHY6R DM3VF9M MN Glycogen phosphorylase muscle form (GP) DM3VF9M MT DTT DM3VF9M MA Inhibitor DM3VF9M RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DM3VF9M RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMNMYWI DI DMNMYWI DMNMYWI DN C-(2'-Chloro-biphenyl-2-yl)-methylamine DMNMYWI MI TTDIGC1 DMNMYWI MN Dipeptidyl peptidase 4 (DPP-4) DMNMYWI MT DTT DMNMYWI MA Inhibitor DMNMYWI RN In silico fragment-based discovery of DPP-IV S1 pocket binders. Bioorg Med Chem Lett. 2006 Mar 1;16(5):1405-9. DMNMYWI RU https://pubmed.ncbi.nlm.nih.gov/16321524 DM0VKFO DI DM0VKFO DM0VKFO DN C-(5-bromo-4,7-dimethoxyindan-1-yl)methylamine DM0VKFO MI TTJQOD7 DM0VKFO MN 5-HT 2A receptor (HTR2A) DM0VKFO MT DTT DM0VKFO MA Inhibitor DM0VKFO RN 1-Aminomethylbenzocycloalkanes: conformationally restricted hallucinogenic phenethylamine analogues as functionally selective 5-HT2A receptor agoni... J Med Chem. 2006 Sep 21;49(19):5794-803. DM0VKFO RU https://pubmed.ncbi.nlm.nih.gov/16970404 DMDHVY0 DI DMDHVY0 DMDHVY0 DN C-(5H-Dibenzo[a,d]cyclohepten-5-yl)-methylamine DMDHVY0 MI TTJQOD7 DMDHVY0 MN 5-HT 2A receptor (HTR2A) DMDHVY0 MT DTT DMDHVY0 MA Inhibitor DMDHVY0 RN Exploring the relationship between binding modes of 9-(aminomethyl)-9,10-dihydroanthracene and cyproheptadine analogues at the 5-HT2A serotonin rec... Bioorg Med Chem Lett. 2001 Feb 26;11(4):563-6. DMDHVY0 RU https://pubmed.ncbi.nlm.nih.gov/11229772 DMJ6SYI DI DMJ6SYI DMJ6SYI DN C-(6-Methoxy-naphthalen-1-yl)-methylamine DMJ6SYI MI TTWG9A4 DMJ6SYI MN Adrenergic receptor alpha-2A (ADRA2A) DMJ6SYI MT DTT DMJ6SYI MA Inhibitor DMJ6SYI RN Examination of the role of the acidic hydrogen in imparting selectivity of 7-(aminosulfonyl)-1,2,3,4-tetrahydroisoquinoline (SK&F 29661) toward inh... J Med Chem. 1997 Dec 5;40(25):3997-4005. DMJ6SYI RU https://pubmed.ncbi.nlm.nih.gov/9406590 DMJ6SYI DI DMJ6SYI DMJ6SYI DN C-(6-Methoxy-naphthalen-1-yl)-methylamine DMJ6SYI MI TTWM4TY DMJ6SYI MN Adrenergic receptor alpha-2B (ADRA2B) DMJ6SYI MT DTT DMJ6SYI MA Inhibitor DMJ6SYI RN Examination of the role of the acidic hydrogen in imparting selectivity of 7-(aminosulfonyl)-1,2,3,4-tetrahydroisoquinoline (SK&F 29661) toward inh... J Med Chem. 1997 Dec 5;40(25):3997-4005. DMJ6SYI RU https://pubmed.ncbi.nlm.nih.gov/9406590 DMJ6SYI DI DMJ6SYI DMJ6SYI DN C-(6-Methoxy-naphthalen-1-yl)-methylamine DMJ6SYI MI TT2NUT5 DMJ6SYI MN Adrenergic receptor alpha-2C (ADRA2C) DMJ6SYI MT DTT DMJ6SYI MA Inhibitor DMJ6SYI RN Examination of the role of the acidic hydrogen in imparting selectivity of 7-(aminosulfonyl)-1,2,3,4-tetrahydroisoquinoline (SK&F 29661) toward inh... J Med Chem. 1997 Dec 5;40(25):3997-4005. DMJ6SYI RU https://pubmed.ncbi.nlm.nih.gov/9406590 DMDMA4Z DI DMDMA4Z DMDMA4Z DN C-(9H-Thioxanthen-9-yl)-methylamine DMDMA4Z MI TTJQOD7 DMDMA4Z MN 5-HT 2A receptor (HTR2A) DMDMA4Z MT DTT DMDMA4Z MA Inhibitor DMDMA4Z RN Exploring the relationship between binding modes of 9-(aminomethyl)-9,10-dihydroanthracene and cyproheptadine analogues at the 5-HT2A serotonin rec... Bioorg Med Chem Lett. 2001 Feb 26;11(4):563-6. DMDMA4Z RU https://pubmed.ncbi.nlm.nih.gov/11229772 DMN5YOR DI DMN5YOR DMN5YOR DN C-(9H-Xanthen-9-yl)-methylamine DMN5YOR MI TTJQOD7 DMN5YOR MN 5-HT 2A receptor (HTR2A) DMN5YOR MT DTT DMN5YOR MA Inhibitor DMN5YOR RN Exploring the relationship between binding modes of 9-(aminomethyl)-9,10-dihydroanthracene and cyproheptadine analogues at the 5-HT2A serotonin rec... Bioorg Med Chem Lett. 2001 Feb 26;11(4):563-6. DMN5YOR RU https://pubmed.ncbi.nlm.nih.gov/11229772 DMHNZGP DI DMHNZGP DMHNZGP DN C(Arg-Gly-Asp-D-Phe-Val) DMHNZGP MI TTT1R2L DMHNZGP MN Integrin alpha-V (ITGAV) DMHNZGP MT DTT DMHNZGP MA Inhibitor DMHNZGP RN Novel and selective alpha(v)beta3 receptor peptide antagonist: design, synthesis, and biological behavior. J Med Chem. 2006 Jun 1;49(11):3416-20. DMHNZGP RU https://pubmed.ncbi.nlm.nih.gov/16722662 DMHNZGP DI DMHNZGP DMHNZGP DN C(Arg-Gly-Asp-D-Phe-Val) DMHNZGP MI TTJA1ZO DMHNZGP MN ITGB3 messenger RNA (ITGB3 mRNA) DMHNZGP MT DTT DMHNZGP MA Inhibitor DMHNZGP RN Novel and selective alpha(v)beta3 receptor peptide antagonist: design, synthesis, and biological behavior. J Med Chem. 2006 Jun 1;49(11):3416-20. DMHNZGP RU https://pubmed.ncbi.nlm.nih.gov/16722662 DMTMJAI DI DMTMJAI DMTMJAI DN C(-GRGDfL-) DMTMJAI MI TTHIZP9 DMTMJAI MN Integrin alpha-5 (ITGA5) DMTMJAI MT DTT DMTMJAI MA Inhibitor DMTMJAI RN Multiple N-methylation by a designed approach enhances receptor selectivity. J Med Chem. 2007 Nov 29;50(24):5878-81. DMTMJAI RU https://pubmed.ncbi.nlm.nih.gov/17973471 DMTMJAI DI DMTMJAI DMTMJAI DN C(-GRGDfL-) DMTMJAI MI TTT1R2L DMTMJAI MN Integrin alpha-V (ITGAV) DMTMJAI MT DTT DMTMJAI MA Inhibitor DMTMJAI RN Multiple N-methylation by a designed approach enhances receptor selectivity. J Med Chem. 2007 Nov 29;50(24):5878-81. DMTMJAI RU https://pubmed.ncbi.nlm.nih.gov/17973471 DMTMJAI DI DMTMJAI DMTMJAI DN C(-GRGDfL-) DMTMJAI MI TTBVIQC DMTMJAI MN Integrin beta-1 (ITGB1) DMTMJAI MT DTT DMTMJAI MA Inhibitor DMTMJAI RN Multiple N-methylation by a designed approach enhances receptor selectivity. J Med Chem. 2007 Nov 29;50(24):5878-81. DMTMJAI RU https://pubmed.ncbi.nlm.nih.gov/17973471 DMTMJAI DI DMTMJAI DMTMJAI DN C(-GRGDfL-) DMTMJAI MI TTJA1ZO DMTMJAI MN ITGB3 messenger RNA (ITGB3 mRNA) DMTMJAI MT DTT DMTMJAI MA Inhibitor DMTMJAI RN Multiple N-methylation by a designed approach enhances receptor selectivity. J Med Chem. 2007 Nov 29;50(24):5878-81. DMTMJAI RU https://pubmed.ncbi.nlm.nih.gov/17973471 DMSLYHQ DI DMSLYHQ DMSLYHQ DN C(his-D-phe-arg-trp-Abu) DMSLYHQ MI TTD0CIQ DMSLYHQ MN Melanocortin receptor 4 (MC4R) DMSLYHQ MT DTT DMSLYHQ MA Inhibitor DMSLYHQ RN Design of cyclic peptides with agonist activity at melanocortin receptor-4. Bioorg Med Chem Lett. 2006 Jul 15;16(14):3723-6. DMSLYHQ RU https://pubmed.ncbi.nlm.nih.gov/16678415 DM0IJFZ DI DM0IJFZ DM0IJFZ DN C(his-D-phe-arg-trp-Ahp) DM0IJFZ MI TTD0CIQ DM0IJFZ MN Melanocortin receptor 4 (MC4R) DM0IJFZ MT DTT DM0IJFZ MA Inhibitor DM0IJFZ RN Design of cyclic peptides with agonist activity at melanocortin receptor-4. Bioorg Med Chem Lett. 2006 Jul 15;16(14):3723-6. DM0IJFZ RU https://pubmed.ncbi.nlm.nih.gov/16678415 DMJKHAB DI DMJKHAB DMJKHAB DN C(his-D-phe-arg-trp-Ahx) DMJKHAB MI TTD0CIQ DMJKHAB MN Melanocortin receptor 4 (MC4R) DMJKHAB MT DTT DMJKHAB MA Inhibitor DMJKHAB RN Design of cyclic peptides with agonist activity at melanocortin receptor-4. Bioorg Med Chem Lett. 2006 Jul 15;16(14):3723-6. DMJKHAB RU https://pubmed.ncbi.nlm.nih.gov/16678415 DM5NQUA DI DM5NQUA DM5NQUA DN C(his-D-phe-arg-trp-Aoc) DM5NQUA MI TTD0CIQ DM5NQUA MN Melanocortin receptor 4 (MC4R) DM5NQUA MT DTT DM5NQUA MA Inhibitor DM5NQUA RN Design of cyclic peptides with agonist activity at melanocortin receptor-4. Bioorg Med Chem Lett. 2006 Jul 15;16(14):3723-6. DM5NQUA RU https://pubmed.ncbi.nlm.nih.gov/16678415 DMEC2PH DI DMEC2PH DMEC2PH DN C(his-L-phe-arg-trp-Aoc) DMEC2PH MI TTD0CIQ DMEC2PH MN Melanocortin receptor 4 (MC4R) DMEC2PH MT DTT DMEC2PH MA Inhibitor DMEC2PH RN Design of cyclic peptides with agonist activity at melanocortin receptor-4. Bioorg Med Chem Lett. 2006 Jul 15;16(14):3723-6. DMEC2PH RU https://pubmed.ncbi.nlm.nih.gov/16678415 DMMBESU DI DMMBESU DMMBESU DN C(RGDfF) DMMBESU MI TTT1R2L DMMBESU MN Integrin alpha-V (ITGAV) DMMBESU MT DTT DMMBESU MA Inhibitor DMMBESU RN Incorporation of the unusual C(alpha)-fluoroalkylamino acids into cyclopeptides: synthesis of arginine-glycine-aspartate (RGD) analogues and study ... J Med Chem. 2006 Mar 9;49(5):1808-17. DMMBESU RU https://pubmed.ncbi.nlm.nih.gov/16509596 DMMBESU DI DMMBESU DMMBESU DN C(RGDfF) DMMBESU MI TTJA1ZO DMMBESU MN ITGB3 messenger RNA (ITGB3 mRNA) DMMBESU MT DTT DMMBESU MA Inhibitor DMMBESU RN Incorporation of the unusual C(alpha)-fluoroalkylamino acids into cyclopeptides: synthesis of arginine-glycine-aspartate (RGD) analogues and study ... J Med Chem. 2006 Mar 9;49(5):1808-17. DMMBESU RU https://pubmed.ncbi.nlm.nih.gov/16509596 DM8DU42 DI DM8DU42 DM8DU42 DN C(RGDfMeF) DM8DU42 MI TTT1R2L DM8DU42 MN Integrin alpha-V (ITGAV) DM8DU42 MT DTT DM8DU42 MA Inhibitor DM8DU42 RN Incorporation of the unusual C(alpha)-fluoroalkylamino acids into cyclopeptides: synthesis of arginine-glycine-aspartate (RGD) analogues and study ... J Med Chem. 2006 Mar 9;49(5):1808-17. DM8DU42 RU https://pubmed.ncbi.nlm.nih.gov/16509596 DM8DU42 DI DM8DU42 DM8DU42 DN C(RGDfMeF) DM8DU42 MI TTJA1ZO DM8DU42 MN ITGB3 messenger RNA (ITGB3 mRNA) DM8DU42 MT DTT DM8DU42 MA Inhibitor DM8DU42 RN Incorporation of the unusual C(alpha)-fluoroalkylamino acids into cyclopeptides: synthesis of arginine-glycine-aspartate (RGD) analogues and study ... J Med Chem. 2006 Mar 9;49(5):1808-17. DM8DU42 RU https://pubmed.ncbi.nlm.nih.gov/16509596 DMY2NU8 DI DMY2NU8 DMY2NU8 DN C-[2-(1H-Imidazol-4-yl)-cyclopropyl]-methylamine DMY2NU8 MI TT9JNIC DMY2NU8 MN Histamine H3 receptor (H3R) DMY2NU8 MT DTT DMY2NU8 MA Inhibitor DMY2NU8 RN Cyclopropane-based conformational restriction of histamine. (1S,2S)-2-(2-aminoethyl)-1-(1H-imidazol-4-yl)cyclopropane, a highly selective agonist f... J Med Chem. 2003 May 8;46(10):1980-8. DMY2NU8 RU https://pubmed.ncbi.nlm.nih.gov/12723960 DMPOIDK DI DMPOIDK DMPOIDK DN C[-Arg-Gly-Asp-Acpca19-] DMPOIDK MI TTT1R2L DMPOIDK MN Integrin alpha-V (ITGAV) DMPOIDK MT DTT DMPOIDK MA Inhibitor DMPOIDK RN Grafting aminocyclopentane carboxylic acids onto the RGD tripeptide sequence generates low nanomolar alphaVbeta3/alphaVbeta5 integrin dual binders. J Med Chem. 2005 Dec 1;48(24):7675-87. DMPOIDK RU https://pubmed.ncbi.nlm.nih.gov/16302808 DMPOIDK DI DMPOIDK DMPOIDK DN C[-Arg-Gly-Asp-Acpca19-] DMPOIDK MI TTJA1ZO DMPOIDK MN ITGB3 messenger RNA (ITGB3 mRNA) DMPOIDK MT DTT DMPOIDK MA Inhibitor DMPOIDK RN Grafting aminocyclopentane carboxylic acids onto the RGD tripeptide sequence generates low nanomolar alphaVbeta3/alphaVbeta5 integrin dual binders. J Med Chem. 2005 Dec 1;48(24):7675-87. DMPOIDK RU https://pubmed.ncbi.nlm.nih.gov/16302808 DMJVW1N DI DMJVW1N DMJVW1N DN C[-Arg-Gly-Asp-Acpca20-] DMJVW1N MI TTT1R2L DMJVW1N MN Integrin alpha-V (ITGAV) DMJVW1N MT DTT DMJVW1N MA Inhibitor DMJVW1N RN Grafting aminocyclopentane carboxylic acids onto the RGD tripeptide sequence generates low nanomolar alphaVbeta3/alphaVbeta5 integrin dual binders. J Med Chem. 2005 Dec 1;48(24):7675-87. DMJVW1N RU https://pubmed.ncbi.nlm.nih.gov/16302808 DMJVW1N DI DMJVW1N DMJVW1N DN C[-Arg-Gly-Asp-Acpca20-] DMJVW1N MI TTJA1ZO DMJVW1N MN ITGB3 messenger RNA (ITGB3 mRNA) DMJVW1N MT DTT DMJVW1N MA Inhibitor DMJVW1N RN Grafting aminocyclopentane carboxylic acids onto the RGD tripeptide sequence generates low nanomolar alphaVbeta3/alphaVbeta5 integrin dual binders. J Med Chem. 2005 Dec 1;48(24):7675-87. DMJVW1N RU https://pubmed.ncbi.nlm.nih.gov/16302808 DMXCUDV DI DMXCUDV DMXCUDV DN C[-Arg-Gly-Asp-Acpca21-] DMXCUDV MI TTT1R2L DMXCUDV MN Integrin alpha-V (ITGAV) DMXCUDV MT DTT DMXCUDV MA Inhibitor DMXCUDV RN Grafting aminocyclopentane carboxylic acids onto the RGD tripeptide sequence generates low nanomolar alphaVbeta3/alphaVbeta5 integrin dual binders. J Med Chem. 2005 Dec 1;48(24):7675-87. DMXCUDV RU https://pubmed.ncbi.nlm.nih.gov/16302808 DMXCUDV DI DMXCUDV DMXCUDV DN C[-Arg-Gly-Asp-Acpca21-] DMXCUDV MI TTJA1ZO DMXCUDV MN ITGB3 messenger RNA (ITGB3 mRNA) DMXCUDV MT DTT DMXCUDV MA Inhibitor DMXCUDV RN Grafting aminocyclopentane carboxylic acids onto the RGD tripeptide sequence generates low nanomolar alphaVbeta3/alphaVbeta5 integrin dual binders. J Med Chem. 2005 Dec 1;48(24):7675-87. DMXCUDV RU https://pubmed.ncbi.nlm.nih.gov/16302808 DM6DV90 DI DM6DV90 DM6DV90 DN C[-Arg-Gly-Asp-Acpca22-] DM6DV90 MI TTT1R2L DM6DV90 MN Integrin alpha-V (ITGAV) DM6DV90 MT DTT DM6DV90 MA Inhibitor DM6DV90 RN Grafting aminocyclopentane carboxylic acids onto the RGD tripeptide sequence generates low nanomolar alphaVbeta3/alphaVbeta5 integrin dual binders. J Med Chem. 2005 Dec 1;48(24):7675-87. DM6DV90 RU https://pubmed.ncbi.nlm.nih.gov/16302808 DM6DV90 DI DM6DV90 DM6DV90 DN C[-Arg-Gly-Asp-Acpca22-] DM6DV90 MI TTJA1ZO DM6DV90 MN ITGB3 messenger RNA (ITGB3 mRNA) DM6DV90 MT DTT DM6DV90 MA Inhibitor DM6DV90 RN Grafting aminocyclopentane carboxylic acids onto the RGD tripeptide sequence generates low nanomolar alphaVbeta3/alphaVbeta5 integrin dual binders. J Med Chem. 2005 Dec 1;48(24):7675-87. DM6DV90 RU https://pubmed.ncbi.nlm.nih.gov/16302808 DML0U8B DI DML0U8B DML0U8B DN C-[-Arg-Gly-Asp-Acpca30-] DML0U8B MI TTT1R2L DML0U8B MN Integrin alpha-V (ITGAV) DML0U8B MT DTT DML0U8B MA Inhibitor DML0U8B RN Grafting aminocyclopentane carboxylic acids onto the RGD tripeptide sequence generates low nanomolar alphaVbeta3/alphaVbeta5 integrin dual binders. J Med Chem. 2005 Dec 1;48(24):7675-87. DML0U8B RU https://pubmed.ncbi.nlm.nih.gov/16302808 DML0U8B DI DML0U8B DML0U8B DN C-[-Arg-Gly-Asp-Acpca30-] DML0U8B MI TTJA1ZO DML0U8B MN ITGB3 messenger RNA (ITGB3 mRNA) DML0U8B MT DTT DML0U8B MA Inhibitor DML0U8B RN Grafting aminocyclopentane carboxylic acids onto the RGD tripeptide sequence generates low nanomolar alphaVbeta3/alphaVbeta5 integrin dual binders. J Med Chem. 2005 Dec 1;48(24):7675-87. DML0U8B RU https://pubmed.ncbi.nlm.nih.gov/16302808 DMKENFU DI DMKENFU DMKENFU DN C-[-Arg-Gly-Asp-Acpca31-] DMKENFU MI TTT1R2L DMKENFU MN Integrin alpha-V (ITGAV) DMKENFU MT DTT DMKENFU MA Inhibitor DMKENFU RN Grafting aminocyclopentane carboxylic acids onto the RGD tripeptide sequence generates low nanomolar alphaVbeta3/alphaVbeta5 integrin dual binders. J Med Chem. 2005 Dec 1;48(24):7675-87. DMKENFU RU https://pubmed.ncbi.nlm.nih.gov/16302808 DMKENFU DI DMKENFU DMKENFU DN C-[-Arg-Gly-Asp-Acpca31-] DMKENFU MI TTJA1ZO DMKENFU MN ITGB3 messenger RNA (ITGB3 mRNA) DMKENFU MT DTT DMKENFU MA Inhibitor DMKENFU RN Grafting aminocyclopentane carboxylic acids onto the RGD tripeptide sequence generates low nanomolar alphaVbeta3/alphaVbeta5 integrin dual binders. J Med Chem. 2005 Dec 1;48(24):7675-87. DMKENFU RU https://pubmed.ncbi.nlm.nih.gov/16302808 DMVM7B2 DI DMVM7B2 DMVM7B2 DN C-[-Arg-Gly-Asp-Acpca32-] DMVM7B2 MI TTT1R2L DMVM7B2 MN Integrin alpha-V (ITGAV) DMVM7B2 MT DTT DMVM7B2 MA Inhibitor DMVM7B2 RN Grafting aminocyclopentane carboxylic acids onto the RGD tripeptide sequence generates low nanomolar alphaVbeta3/alphaVbeta5 integrin dual binders. J Med Chem. 2005 Dec 1;48(24):7675-87. DMVM7B2 RU https://pubmed.ncbi.nlm.nih.gov/16302808 DMVM7B2 DI DMVM7B2 DMVM7B2 DN C-[-Arg-Gly-Asp-Acpca32-] DMVM7B2 MI TTJA1ZO DMVM7B2 MN ITGB3 messenger RNA (ITGB3 mRNA) DMVM7B2 MT DTT DMVM7B2 MA Inhibitor DMVM7B2 RN Grafting aminocyclopentane carboxylic acids onto the RGD tripeptide sequence generates low nanomolar alphaVbeta3/alphaVbeta5 integrin dual binders. J Med Chem. 2005 Dec 1;48(24):7675-87. DMVM7B2 RU https://pubmed.ncbi.nlm.nih.gov/16302808 DMIBGWO DI DMIBGWO DMIBGWO DN C-[-Arg-Gly-Asp-Acpca33-] DMIBGWO MI TTT1R2L DMIBGWO MN Integrin alpha-V (ITGAV) DMIBGWO MT DTT DMIBGWO MA Inhibitor DMIBGWO RN Grafting aminocyclopentane carboxylic acids onto the RGD tripeptide sequence generates low nanomolar alphaVbeta3/alphaVbeta5 integrin dual binders. J Med Chem. 2005 Dec 1;48(24):7675-87. DMIBGWO RU https://pubmed.ncbi.nlm.nih.gov/16302808 DMIBGWO DI DMIBGWO DMIBGWO DN C-[-Arg-Gly-Asp-Acpca33-] DMIBGWO MI TTJA1ZO DMIBGWO MN ITGB3 messenger RNA (ITGB3 mRNA) DMIBGWO MT DTT DMIBGWO MA Inhibitor DMIBGWO RN Grafting aminocyclopentane carboxylic acids onto the RGD tripeptide sequence generates low nanomolar alphaVbeta3/alphaVbeta5 integrin dual binders. J Med Chem. 2005 Dec 1;48(24):7675-87. DMIBGWO RU https://pubmed.ncbi.nlm.nih.gov/16302808 DMKHSAV DI DMKHSAV DMKHSAV DN C[-Arg-Gly-Asp-Acpca34-] DMKHSAV MI TTT1R2L DMKHSAV MN Integrin alpha-V (ITGAV) DMKHSAV MT DTT DMKHSAV MA Inhibitor DMKHSAV RN Grafting aminocyclopentane carboxylic acids onto the RGD tripeptide sequence generates low nanomolar alphaVbeta3/alphaVbeta5 integrin dual binders. J Med Chem. 2005 Dec 1;48(24):7675-87. DMKHSAV RU https://pubmed.ncbi.nlm.nih.gov/16302808 DMKHSAV DI DMKHSAV DMKHSAV DN C[-Arg-Gly-Asp-Acpca34-] DMKHSAV MI TTJA1ZO DMKHSAV MN ITGB3 messenger RNA (ITGB3 mRNA) DMKHSAV MT DTT DMKHSAV MA Inhibitor DMKHSAV RN Grafting aminocyclopentane carboxylic acids onto the RGD tripeptide sequence generates low nanomolar alphaVbeta3/alphaVbeta5 integrin dual binders. J Med Chem. 2005 Dec 1;48(24):7675-87. DMKHSAV RU https://pubmed.ncbi.nlm.nih.gov/16302808 DMQOY3J DI DMQOY3J DMQOY3J DN C[-Arg-Gly-Asp-Acpca35-] DMQOY3J MI TTT1R2L DMQOY3J MN Integrin alpha-V (ITGAV) DMQOY3J MT DTT DMQOY3J MA Inhibitor DMQOY3J RN Grafting aminocyclopentane carboxylic acids onto the RGD tripeptide sequence generates low nanomolar alphaVbeta3/alphaVbeta5 integrin dual binders. J Med Chem. 2005 Dec 1;48(24):7675-87. DMQOY3J RU https://pubmed.ncbi.nlm.nih.gov/16302808 DMQOY3J DI DMQOY3J DMQOY3J DN C[-Arg-Gly-Asp-Acpca35-] DMQOY3J MI TTJA1ZO DMQOY3J MN ITGB3 messenger RNA (ITGB3 mRNA) DMQOY3J MT DTT DMQOY3J MA Inhibitor DMQOY3J RN Grafting aminocyclopentane carboxylic acids onto the RGD tripeptide sequence generates low nanomolar alphaVbeta3/alphaVbeta5 integrin dual binders. J Med Chem. 2005 Dec 1;48(24):7675-87. DMQOY3J RU https://pubmed.ncbi.nlm.nih.gov/16302808 DM7LCPW DI DM7LCPW DM7LCPW DN C[-Arg-Gly-Asp-Acpca36-] DM7LCPW MI TTT1R2L DM7LCPW MN Integrin alpha-V (ITGAV) DM7LCPW MT DTT DM7LCPW MA Inhibitor DM7LCPW RN Grafting aminocyclopentane carboxylic acids onto the RGD tripeptide sequence generates low nanomolar alphaVbeta3/alphaVbeta5 integrin dual binders. J Med Chem. 2005 Dec 1;48(24):7675-87. DM7LCPW RU https://pubmed.ncbi.nlm.nih.gov/16302808 DM7LCPW DI DM7LCPW DM7LCPW DN C[-Arg-Gly-Asp-Acpca36-] DM7LCPW MI TTJA1ZO DM7LCPW MN ITGB3 messenger RNA (ITGB3 mRNA) DM7LCPW MT DTT DM7LCPW MA Inhibitor DM7LCPW RN Grafting aminocyclopentane carboxylic acids onto the RGD tripeptide sequence generates low nanomolar alphaVbeta3/alphaVbeta5 integrin dual binders. J Med Chem. 2005 Dec 1;48(24):7675-87. DM7LCPW RU https://pubmed.ncbi.nlm.nih.gov/16302808 DMISP20 DI DMISP20 DMISP20 DN C[Asp22-Lys26][Gly8]GLP-1(7-37)-NH2 DMISP20 MI TTVIMDE DMISP20 MN Glucagon-like peptide 1 receptor (GLP1R) DMISP20 MT DTT DMISP20 MA Inhibitor DMISP20 RN Design and synthesis of conformationally constrained glucagon-like peptide-1 derivatives with increased plasma stability and prolonged in vivo acti... J Med Chem. 2008 May 8;51(9):2758-65. DMISP20 RU https://pubmed.ncbi.nlm.nih.gov/18412318 DMHARQX DI DMHARQX DMHARQX DN C[CO-(CH2)2-CO-Nle-D-Nal(2)-Arg-Trp-Lys]-NH2 DMHARQX MI TTEOSZT DMHARQX MN Melanocortin receptor (MCR) DMHARQX MT DTT DMHARQX MA Inhibitor DMHARQX RN Structure-activity relationships of cyclic lactam analogues of alpha-melanocyte-stimulating hormone (alpha-MSH) targeting the human melanocortin-3 ... J Med Chem. 2008 Jan 24;51(2):187-95. DMHARQX RU https://pubmed.ncbi.nlm.nih.gov/18088090 DMHARQX DI DMHARQX DMHARQX DN C[CO-(CH2)2-CO-Nle-D-Nal(2)-Arg-Trp-Lys]-NH2 DMHARQX MI TT0MV2T DMHARQX MN Melanocortin receptor 1 (MC1R) DMHARQX MT DTT DMHARQX MA Inhibitor DMHARQX RN Structure-activity relationships of cyclic lactam analogues of alpha-melanocyte-stimulating hormone (alpha-MSH) targeting the human melanocortin-3 ... J Med Chem. 2008 Jan 24;51(2):187-95. DMHARQX RU https://pubmed.ncbi.nlm.nih.gov/18088090 DMHARQX DI DMHARQX DMHARQX DN C[CO-(CH2)2-CO-Nle-D-Nal(2)-Arg-Trp-Lys]-NH2 DMHARQX MI TTNI91K DMHARQX MN Melanocortin receptor 3 (MC3R) DMHARQX MT DTT DMHARQX MA Inhibitor DMHARQX RN Structure-activity relationships of cyclic lactam analogues of alpha-melanocyte-stimulating hormone (alpha-MSH) targeting the human melanocortin-3 ... J Med Chem. 2008 Jan 24;51(2):187-95. DMHARQX RU https://pubmed.ncbi.nlm.nih.gov/18088090 DMHARQX DI DMHARQX DMHARQX DN C[CO-(CH2)2-CO-Nle-D-Nal(2)-Arg-Trp-Lys]-NH2 DMHARQX MI TTD0CIQ DMHARQX MN Melanocortin receptor 4 (MC4R) DMHARQX MT DTT DMHARQX MA Inhibitor DMHARQX RN Structure-activity relationships of cyclic lactam analogues of alpha-melanocyte-stimulating hormone (alpha-MSH) targeting the human melanocortin-3 ... J Med Chem. 2008 Jan 24;51(2):187-95. DMHARQX RU https://pubmed.ncbi.nlm.nih.gov/18088090 DMI3CSJ DI DMI3CSJ DMI3CSJ DN C[CO-(CH2)2-CO-Nle-D-Phe-Arg-Trp-Lys]-NH2 DMI3CSJ MI TTEOSZT DMI3CSJ MN Melanocortin receptor (MCR) DMI3CSJ MT DTT DMI3CSJ MA Inhibitor DMI3CSJ RN Structure-activity relationships of cyclic lactam analogues of alpha-melanocyte-stimulating hormone (alpha-MSH) targeting the human melanocortin-3 ... J Med Chem. 2008 Jan 24;51(2):187-95. DMI3CSJ RU https://pubmed.ncbi.nlm.nih.gov/18088090 DMI3CSJ DI DMI3CSJ DMI3CSJ DN C[CO-(CH2)2-CO-Nle-D-Phe-Arg-Trp-Lys]-NH2 DMI3CSJ MI TTNI91K DMI3CSJ MN Melanocortin receptor 3 (MC3R) DMI3CSJ MT DTT DMI3CSJ MA Inhibitor DMI3CSJ RN Structure-activity relationships of cyclic lactam analogues of alpha-melanocyte-stimulating hormone (alpha-MSH) targeting the human melanocortin-3 ... J Med Chem. 2008 Jan 24;51(2):187-95. DMI3CSJ RU https://pubmed.ncbi.nlm.nih.gov/18088090 DMI3CSJ DI DMI3CSJ DMI3CSJ DN C[CO-(CH2)2-CO-Nle-D-Phe-Arg-Trp-Lys]-NH2 DMI3CSJ MI TTD0CIQ DMI3CSJ MN Melanocortin receptor 4 (MC4R) DMI3CSJ MT DTT DMI3CSJ MA Inhibitor DMI3CSJ RN Structure-activity relationships of cyclic lactam analogues of alpha-melanocyte-stimulating hormone (alpha-MSH) targeting the human melanocortin-3 ... J Med Chem. 2008 Jan 24;51(2):187-95. DMI3CSJ RU https://pubmed.ncbi.nlm.nih.gov/18088090 DMYPHVC DI DMYPHVC DMYPHVC DN C[CO-(CH2)3-CO-Pro-D-Nal(2)-Arg-Trp-Lys]-NH2 DMYPHVC MI TTEOSZT DMYPHVC MN Melanocortin receptor (MCR) DMYPHVC MT DTT DMYPHVC MA Inhibitor DMYPHVC RN Structure-activity relationships of cyclic lactam analogues of alpha-melanocyte-stimulating hormone (alpha-MSH) targeting the human melanocortin-3 ... J Med Chem. 2008 Jan 24;51(2):187-95. DMYPHVC RU https://pubmed.ncbi.nlm.nih.gov/18088090 DMYPHVC DI DMYPHVC DMYPHVC DN C[CO-(CH2)3-CO-Pro-D-Nal(2)-Arg-Trp-Lys]-NH2 DMYPHVC MI TTNI91K DMYPHVC MN Melanocortin receptor 3 (MC3R) DMYPHVC MT DTT DMYPHVC MA Inhibitor DMYPHVC RN Structure-activity relationships of cyclic lactam analogues of alpha-melanocyte-stimulating hormone (alpha-MSH) targeting the human melanocortin-3 ... J Med Chem. 2008 Jan 24;51(2):187-95. DMYPHVC RU https://pubmed.ncbi.nlm.nih.gov/18088090 DMYPHVC DI DMYPHVC DMYPHVC DN C[CO-(CH2)3-CO-Pro-D-Nal(2)-Arg-Trp-Lys]-NH2 DMYPHVC MI TTD0CIQ DMYPHVC MN Melanocortin receptor 4 (MC4R) DMYPHVC MT DTT DMYPHVC MA Inhibitor DMYPHVC RN Structure-activity relationships of cyclic lactam analogues of alpha-melanocyte-stimulating hormone (alpha-MSH) targeting the human melanocortin-3 ... J Med Chem. 2008 Jan 24;51(2):187-95. DMYPHVC RU https://pubmed.ncbi.nlm.nih.gov/18088090 DM0VP79 DI DM0VP79 DM0VP79 DN C[CO-(CH2)3-CO-Pro-D-Phe-Arg-Trp-Lys]-NH2 DM0VP79 MI TTEOSZT DM0VP79 MN Melanocortin receptor (MCR) DM0VP79 MT DTT DM0VP79 MA Inhibitor DM0VP79 RN Structure-activity relationships of cyclic lactam analogues of alpha-melanocyte-stimulating hormone (alpha-MSH) targeting the human melanocortin-3 ... J Med Chem. 2008 Jan 24;51(2):187-95. DM0VP79 RU https://pubmed.ncbi.nlm.nih.gov/18088090 DM0VP79 DI DM0VP79 DM0VP79 DN C[CO-(CH2)3-CO-Pro-D-Phe-Arg-Trp-Lys]-NH2 DM0VP79 MI TTNI91K DM0VP79 MN Melanocortin receptor 3 (MC3R) DM0VP79 MT DTT DM0VP79 MA Inhibitor DM0VP79 RN Structure-activity relationships of cyclic lactam analogues of alpha-melanocyte-stimulating hormone (alpha-MSH) targeting the human melanocortin-3 ... J Med Chem. 2008 Jan 24;51(2):187-95. DM0VP79 RU https://pubmed.ncbi.nlm.nih.gov/18088090 DM1VCJP DI DM1VCJP DM1VCJP DN C[CO-2,3-pyrazine-CO-D-Nal(2)-Arg-Trp-Lys]-NH2 DM1VCJP MI TTEOSZT DM1VCJP MN Melanocortin receptor (MCR) DM1VCJP MT DTT DM1VCJP MA Inhibitor DM1VCJP RN Structure-activity relationships of cyclic lactam analogues of alpha-melanocyte-stimulating hormone (alpha-MSH) targeting the human melanocortin-3 ... J Med Chem. 2008 Jan 24;51(2):187-95. DM1VCJP RU https://pubmed.ncbi.nlm.nih.gov/18088090 DM1VCJP DI DM1VCJP DM1VCJP DN C[CO-2,3-pyrazine-CO-D-Nal(2)-Arg-Trp-Lys]-NH2 DM1VCJP MI TT0MV2T DM1VCJP MN Melanocortin receptor 1 (MC1R) DM1VCJP MT DTT DM1VCJP MA Inhibitor DM1VCJP RN Structure-activity relationships of cyclic lactam analogues of alpha-melanocyte-stimulating hormone (alpha-MSH) targeting the human melanocortin-3 ... J Med Chem. 2008 Jan 24;51(2):187-95. DM1VCJP RU https://pubmed.ncbi.nlm.nih.gov/18088090 DM1VCJP DI DM1VCJP DM1VCJP DN C[CO-2,3-pyrazine-CO-D-Nal(2)-Arg-Trp-Lys]-NH2 DM1VCJP MI TTNI91K DM1VCJP MN Melanocortin receptor 3 (MC3R) DM1VCJP MT DTT DM1VCJP MA Inhibitor DM1VCJP RN Structure-activity relationships of cyclic lactam analogues of alpha-melanocyte-stimulating hormone (alpha-MSH) targeting the human melanocortin-3 ... J Med Chem. 2008 Jan 24;51(2):187-95. DM1VCJP RU https://pubmed.ncbi.nlm.nih.gov/18088090 DM8AMGF DI DM8AMGF DM8AMGF DN C[CO-2,3-pyrazine-CO-D-Phe-Arg-Trp-Lys]-NH2 DM8AMGF MI TT0MV2T DM8AMGF MN Melanocortin receptor 1 (MC1R) DM8AMGF MT DTT DM8AMGF MA Inhibitor DM8AMGF RN Structure-activity relationships of cyclic lactam analogues of alpha-melanocyte-stimulating hormone (alpha-MSH) targeting the human melanocortin-3 ... J Med Chem. 2008 Jan 24;51(2):187-95. DM8AMGF RU https://pubmed.ncbi.nlm.nih.gov/18088090 DM8AMGF DI DM8AMGF DM8AMGF DN C[CO-2,3-pyrazine-CO-D-Phe-Arg-Trp-Lys]-NH2 DM8AMGF MI TTNI91K DM8AMGF MN Melanocortin receptor 3 (MC3R) DM8AMGF MT DTT DM8AMGF MA Inhibitor DM8AMGF RN Structure-activity relationships of cyclic lactam analogues of alpha-melanocyte-stimulating hormone (alpha-MSH) targeting the human melanocortin-3 ... J Med Chem. 2008 Jan 24;51(2):187-95. DM8AMGF RU https://pubmed.ncbi.nlm.nih.gov/18088090 DMD6OW4 DI DMD6OW4 DMD6OW4 DN C[CO-o-C6H4-CO-Pro-D-Nal(2)-Arg-Trp-Lys]-NH2 DMD6OW4 MI TTEOSZT DMD6OW4 MN Melanocortin receptor (MCR) DMD6OW4 MT DTT DMD6OW4 MA Inhibitor DMD6OW4 RN Structure-activity relationships of cyclic lactam analogues of alpha-melanocyte-stimulating hormone (alpha-MSH) targeting the human melanocortin-3 ... J Med Chem. 2008 Jan 24;51(2):187-95. DMD6OW4 RU https://pubmed.ncbi.nlm.nih.gov/18088090 DMD6OW4 DI DMD6OW4 DMD6OW4 DN C[CO-o-C6H4-CO-Pro-D-Nal(2)-Arg-Trp-Lys]-NH2 DMD6OW4 MI TT0MV2T DMD6OW4 MN Melanocortin receptor 1 (MC1R) DMD6OW4 MT DTT DMD6OW4 MA Inhibitor DMD6OW4 RN Structure-activity relationships of cyclic lactam analogues of alpha-melanocyte-stimulating hormone (alpha-MSH) targeting the human melanocortin-3 ... J Med Chem. 2008 Jan 24;51(2):187-95. DMD6OW4 RU https://pubmed.ncbi.nlm.nih.gov/18088090 DMD6OW4 DI DMD6OW4 DMD6OW4 DN C[CO-o-C6H4-CO-Pro-D-Nal(2)-Arg-Trp-Lys]-NH2 DMD6OW4 MI TTNI91K DMD6OW4 MN Melanocortin receptor 3 (MC3R) DMD6OW4 MT DTT DMD6OW4 MA Inhibitor DMD6OW4 RN Structure-activity relationships of cyclic lactam analogues of alpha-melanocyte-stimulating hormone (alpha-MSH) targeting the human melanocortin-3 ... J Med Chem. 2008 Jan 24;51(2):187-95. DMD6OW4 RU https://pubmed.ncbi.nlm.nih.gov/18088090 DMD6OW4 DI DMD6OW4 DMD6OW4 DN C[CO-o-C6H4-CO-Pro-D-Nal(2)-Arg-Trp-Lys]-NH2 DMD6OW4 MI TTD0CIQ DMD6OW4 MN Melanocortin receptor 4 (MC4R) DMD6OW4 MT DTT DMD6OW4 MA Inhibitor DMD6OW4 RN Structure-activity relationships of cyclic lactam analogues of alpha-melanocyte-stimulating hormone (alpha-MSH) targeting the human melanocortin-3 ... J Med Chem. 2008 Jan 24;51(2):187-95. DMD6OW4 RU https://pubmed.ncbi.nlm.nih.gov/18088090 DMNKT8J DI DMNKT8J DMNKT8J DN C[CO-o-C6H4-CO-Pro-D-Phe-Arg-Trp-Lys]-NH2 DMNKT8J MI TTD0CIQ DMNKT8J MN Melanocortin receptor 4 (MC4R) DMNKT8J MT DTT DMNKT8J MA Inhibitor DMNKT8J RN Structure-activity relationships of cyclic lactam analogues of alpha-melanocyte-stimulating hormone (alpha-MSH) targeting the human melanocortin-3 ... J Med Chem. 2008 Jan 24;51(2):187-95. DMNKT8J RU https://pubmed.ncbi.nlm.nih.gov/18088090 DMYIJT1 DI DMYIJT1 DMYIJT1 DN C[Cpa19-Lys26][Gly8]GLP-1(7-37)-NH2 DMYIJT1 MI TTVIMDE DMYIJT1 MN Glucagon-like peptide 1 receptor (GLP1R) DMYIJT1 MT DTT DMYIJT1 MA Inhibitor DMYIJT1 RN Design and synthesis of conformationally constrained glucagon-like peptide-1 derivatives with increased plasma stability and prolonged in vivo acti... J Med Chem. 2008 May 8;51(9):2758-65. DMYIJT1 RU https://pubmed.ncbi.nlm.nih.gov/18412318 DMJR5UD DI DMJR5UD DMJR5UD DN C[Glu18-Lys22][Gly8]GLP-1(7-37)-NH2 DMJR5UD MI TTVIMDE DMJR5UD MN Glucagon-like peptide 1 receptor (GLP1R) DMJR5UD MT DTT DMJR5UD MA Inhibitor DMJR5UD RN Design and synthesis of conformationally constrained glucagon-like peptide-1 derivatives with increased plasma stability and prolonged in vivo acti... J Med Chem. 2008 May 8;51(9):2758-65. DMJR5UD RU https://pubmed.ncbi.nlm.nih.gov/18412318 DM6O4EZ DI DM6O4EZ DM6O4EZ DN C[Glu19-Lys23][Gly8]GLP-1(7-37)-NH2 DM6O4EZ MI TTVIMDE DM6O4EZ MN Glucagon-like peptide 1 receptor (GLP1R) DM6O4EZ MT DTT DM6O4EZ MA Inhibitor DM6O4EZ RN Design and synthesis of conformationally constrained glucagon-like peptide-1 derivatives with increased plasma stability and prolonged in vivo acti... J Med Chem. 2008 May 8;51(9):2758-65. DM6O4EZ RU https://pubmed.ncbi.nlm.nih.gov/18412318 DMA3ZRJ DI DMA3ZRJ DMA3ZRJ DN C[Glu21-Lys25][Gly8]GLP-1(7-37)-NH2 DMA3ZRJ MI TTVIMDE DMA3ZRJ MN Glucagon-like peptide 1 receptor (GLP1R) DMA3ZRJ MT DTT DMA3ZRJ MA Inhibitor DMA3ZRJ RN Design and synthesis of conformationally constrained glucagon-like peptide-1 derivatives with increased plasma stability and prolonged in vivo acti... J Med Chem. 2008 May 8;51(9):2758-65. DMA3ZRJ RU https://pubmed.ncbi.nlm.nih.gov/18412318 DMPK74W DI DMPK74W DMPK74W DN C[Glu21-Lys26][Gly8]GLP-1(7-37)-NH2 DMPK74W MI TTVIMDE DMPK74W MN Glucagon-like peptide 1 receptor (GLP1R) DMPK74W MT DTT DMPK74W MA Inhibitor DMPK74W RN Design and synthesis of conformationally constrained glucagon-like peptide-1 derivatives with increased plasma stability and prolonged in vivo acti... J Med Chem. 2008 May 8;51(9):2758-65. DMPK74W RU https://pubmed.ncbi.nlm.nih.gov/18412318 DM8I0CZ DI DM8I0CZ DM8I0CZ DN C[Glu22-Lys26][Gly8]GLP-1(7-37)-NH2 DM8I0CZ MI TTVIMDE DM8I0CZ MN Glucagon-like peptide 1 receptor (GLP1R) DM8I0CZ MT DTT DM8I0CZ MA Inhibitor DM8I0CZ RN Design and synthesis of conformationally constrained glucagon-like peptide-1 derivatives with increased plasma stability and prolonged in vivo acti... J Med Chem. 2008 May 8;51(9):2758-65. DM8I0CZ RU https://pubmed.ncbi.nlm.nih.gov/18412318 DMMA9GE DI DMMA9GE DMMA9GE DN C[Glu22-Orn26][Gly8]GLP-1(7-37)-NH2 DMMA9GE MI TTVIMDE DMMA9GE MN Glucagon-like peptide 1 receptor (GLP1R) DMMA9GE MT DTT DMMA9GE MA Inhibitor DMMA9GE RN Design and synthesis of conformationally constrained glucagon-like peptide-1 derivatives with increased plasma stability and prolonged in vivo acti... J Med Chem. 2008 May 8;51(9):2758-65. DMMA9GE RU https://pubmed.ncbi.nlm.nih.gov/18412318 DMWYN87 DI DMWYN87 DMWYN87 DN C[Glu23-Lys27][Gly8]GLP-1(7-37)-NH2 DMWYN87 MI TTVIMDE DMWYN87 MN Glucagon-like peptide 1 receptor (GLP1R) DMWYN87 MT DTT DMWYN87 MA Inhibitor DMWYN87 RN Design and synthesis of conformationally constrained glucagon-like peptide-1 derivatives with increased plasma stability and prolonged in vivo acti... J Med Chem. 2008 May 8;51(9):2758-65. DMWYN87 RU https://pubmed.ncbi.nlm.nih.gov/18412318 DMKZXV3 DI DMKZXV3 DMKZXV3 DN C[Glu24-Lys28][Gly8]GLP-1(7-37)-NH2 DMKZXV3 MI TTVIMDE DMKZXV3 MN Glucagon-like peptide 1 receptor (GLP1R) DMKZXV3 MT DTT DMKZXV3 MA Inhibitor DMKZXV3 RN Design and synthesis of conformationally constrained glucagon-like peptide-1 derivatives with increased plasma stability and prolonged in vivo acti... J Med Chem. 2008 May 8;51(9):2758-65. DMKZXV3 RU https://pubmed.ncbi.nlm.nih.gov/18412318 DMX2WCZ DI DMX2WCZ DMX2WCZ DN C[Glu26-Lys30][Gly8]GLP-1(7-37)-NH2 DMX2WCZ MI TTVIMDE DMX2WCZ MN Glucagon-like peptide 1 receptor (GLP1R) DMX2WCZ MT DTT DMX2WCZ MA Inhibitor DMX2WCZ RN Design and synthesis of conformationally constrained glucagon-like peptide-1 derivatives with increased plasma stability and prolonged in vivo acti... J Med Chem. 2008 May 8;51(9):2758-65. DMX2WCZ RU https://pubmed.ncbi.nlm.nih.gov/18412318 DMTP5YZ DI DMTP5YZ DMTP5YZ DN C[hGlu22-Lys26][Gly8]GLP-1(7-37)-NH2 DMTP5YZ MI TTVIMDE DMTP5YZ MN Glucagon-like peptide 1 receptor (GLP1R) DMTP5YZ MT DTT DMTP5YZ MA Inhibitor DMTP5YZ RN Design and synthesis of conformationally constrained glucagon-like peptide-1 derivatives with increased plasma stability and prolonged in vivo acti... J Med Chem. 2008 May 8;51(9):2758-65. DMTP5YZ RU https://pubmed.ncbi.nlm.nih.gov/18412318 DM8HK0J DI DM8HK0J DM8HK0J DN C[homoPhe-Hca-Glu-Gly-Leu-Glu-Glu]-NH2 DM8HK0J MI TT1VAUK DM8HK0J MN VEGFR1 messenger RNA (VEGFR1 mRNA) DM8HK0J MT DTT DM8HK0J MA Inhibitor DM8HK0J RN Rational design, structure, and biological evaluation of cyclic peptides mimicking the vascular endothelial growth factor. J Med Chem. 2007 Oct 18;50(21):5135-46. DM8HK0J RU https://pubmed.ncbi.nlm.nih.gov/17900101 DMHXTWK DI DMHXTWK DMHXTWK DN C[L-Ala-D-pro-L-Phe-D-trp] DMHXTWK MI TTQW87Y DMHXTWK MN Opioid receptor kappa (OPRK1) DMHXTWK MT DTT DMHXTWK MA Inhibitor DMHXTWK RN Nascent structure-activity relationship study of a diastereomeric series of kappa opioid receptor antagonists derived from CJ-15,208. Bioorg Med Chem Lett. 2009 Jul 1;19(13):3647-50. DMHXTWK RU https://pubmed.ncbi.nlm.nih.gov/19464172 DMHXTWK DI DMHXTWK DMHXTWK DN C[L-Ala-D-pro-L-Phe-D-trp] DMHXTWK MI TTKWM86 DMHXTWK MN Opioid receptor mu (MOP) DMHXTWK MT DTT DMHXTWK MA Inhibitor DMHXTWK RN Nascent structure-activity relationship study of a diastereomeric series of kappa opioid receptor antagonists derived from CJ-15,208. Bioorg Med Chem Lett. 2009 Jul 1;19(13):3647-50. DMHXTWK RU https://pubmed.ncbi.nlm.nih.gov/19464172 DMNHSR0 DI DMNHSR0 DMNHSR0 DN C[L-mTyr-D-pro-L-Phe-D-trp] DMNHSR0 MI TT27RFC DMNHSR0 MN Opioid receptor delta (OPRD1) DMNHSR0 MT DTT DMNHSR0 MA Inhibitor DMNHSR0 RN Nascent structure-activity relationship study of a diastereomeric series of kappa opioid receptor antagonists derived from CJ-15,208. Bioorg Med Chem Lett. 2009 Jul 1;19(13):3647-50. DMNHSR0 RU https://pubmed.ncbi.nlm.nih.gov/19464172 DMNHSR0 DI DMNHSR0 DMNHSR0 DN C[L-mTyr-D-pro-L-Phe-D-trp] DMNHSR0 MI TTQW87Y DMNHSR0 MN Opioid receptor kappa (OPRK1) DMNHSR0 MT DTT DMNHSR0 MA Inhibitor DMNHSR0 RN Nascent structure-activity relationship study of a diastereomeric series of kappa opioid receptor antagonists derived from CJ-15,208. Bioorg Med Chem Lett. 2009 Jul 1;19(13):3647-50. DMNHSR0 RU https://pubmed.ncbi.nlm.nih.gov/19464172 DMNHSR0 DI DMNHSR0 DMNHSR0 DN C[L-mTyr-D-pro-L-Phe-D-trp] DMNHSR0 MI TTKWM86 DMNHSR0 MN Opioid receptor mu (MOP) DMNHSR0 MT DTT DMNHSR0 MA Inhibitor DMNHSR0 RN Nascent structure-activity relationship study of a diastereomeric series of kappa opioid receptor antagonists derived from CJ-15,208. Bioorg Med Chem Lett. 2009 Jul 1;19(13):3647-50. DMNHSR0 RU https://pubmed.ncbi.nlm.nih.gov/19464172 DM82ZOM DI DM82ZOM DM82ZOM DN C[L-Phe-D-pro-L-mTyr-D-trp] DM82ZOM MI TT27RFC DM82ZOM MN Opioid receptor delta (OPRD1) DM82ZOM MT DTT DM82ZOM MA Inhibitor DM82ZOM RN Nascent structure-activity relationship study of a diastereomeric series of kappa opioid receptor antagonists derived from CJ-15,208. Bioorg Med Chem Lett. 2009 Jul 1;19(13):3647-50. DM82ZOM RU https://pubmed.ncbi.nlm.nih.gov/19464172 DM82ZOM DI DM82ZOM DM82ZOM DN C[L-Phe-D-pro-L-mTyr-D-trp] DM82ZOM MI TTQW87Y DM82ZOM MN Opioid receptor kappa (OPRK1) DM82ZOM MT DTT DM82ZOM MA Inhibitor DM82ZOM RN Nascent structure-activity relationship study of a diastereomeric series of kappa opioid receptor antagonists derived from CJ-15,208. Bioorg Med Chem Lett. 2009 Jul 1;19(13):3647-50. DM82ZOM RU https://pubmed.ncbi.nlm.nih.gov/19464172 DM82ZOM DI DM82ZOM DM82ZOM DN C[L-Phe-D-pro-L-mTyr-D-trp] DM82ZOM MI TTKWM86 DM82ZOM MN Opioid receptor mu (MOP) DM82ZOM MT DTT DM82ZOM MA Inhibitor DM82ZOM RN Nascent structure-activity relationship study of a diastereomeric series of kappa opioid receptor antagonists derived from CJ-15,208. Bioorg Med Chem Lett. 2009 Jul 1;19(13):3647-50. DM82ZOM RU https://pubmed.ncbi.nlm.nih.gov/19464172 DM0NTU5 DI DM0NTU5 DM0NTU5 DN C[L-Phe-D-pro-L-Phe-D-trp] DM0NTU5 MI TTQW87Y DM0NTU5 MN Opioid receptor kappa (OPRK1) DM0NTU5 MT DTT DM0NTU5 MA Inhibitor DM0NTU5 RN Nascent structure-activity relationship study of a diastereomeric series of kappa opioid receptor antagonists derived from CJ-15,208. Bioorg Med Chem Lett. 2009 Jul 1;19(13):3647-50. DM0NTU5 RU https://pubmed.ncbi.nlm.nih.gov/19464172 DM0NTU5 DI DM0NTU5 DM0NTU5 DN C[L-Phe-D-pro-L-Phe-D-trp] DM0NTU5 MI TTKWM86 DM0NTU5 MN Opioid receptor mu (MOP) DM0NTU5 MT DTT DM0NTU5 MA Inhibitor DM0NTU5 RN Nascent structure-activity relationship study of a diastereomeric series of kappa opioid receptor antagonists derived from CJ-15,208. Bioorg Med Chem Lett. 2009 Jul 1;19(13):3647-50. DM0NTU5 RU https://pubmed.ncbi.nlm.nih.gov/19464172 DMCY4L0 DI DMCY4L0 DMCY4L0 DN C[L-Phe-D-pro-L-Phe-L-trp] DMCY4L0 MI TT27RFC DMCY4L0 MN Opioid receptor delta (OPRD1) DMCY4L0 MT DTT DMCY4L0 MA Inhibitor DMCY4L0 RN Nascent structure-activity relationship study of a diastereomeric series of kappa opioid receptor antagonists derived from CJ-15,208. Bioorg Med Chem Lett. 2009 Jul 1;19(13):3647-50. DMCY4L0 RU https://pubmed.ncbi.nlm.nih.gov/19464172 DMCY4L0 DI DMCY4L0 DMCY4L0 DN C[L-Phe-D-pro-L-Phe-L-trp] DMCY4L0 MI TTQW87Y DMCY4L0 MN Opioid receptor kappa (OPRK1) DMCY4L0 MT DTT DMCY4L0 MA Inhibitor DMCY4L0 RN Nascent structure-activity relationship study of a diastereomeric series of kappa opioid receptor antagonists derived from CJ-15,208. Bioorg Med Chem Lett. 2009 Jul 1;19(13):3647-50. DMCY4L0 RU https://pubmed.ncbi.nlm.nih.gov/19464172 DMCY4L0 DI DMCY4L0 DMCY4L0 DN C[L-Phe-D-pro-L-Phe-L-trp] DMCY4L0 MI TTKWM86 DMCY4L0 MN Opioid receptor mu (MOP) DMCY4L0 MT DTT DMCY4L0 MA Inhibitor DMCY4L0 RN Nascent structure-activity relationship study of a diastereomeric series of kappa opioid receptor antagonists derived from CJ-15,208. Bioorg Med Chem Lett. 2009 Jul 1;19(13):3647-50. DMCY4L0 RU https://pubmed.ncbi.nlm.nih.gov/19464172 DM4M3OP DI DM4M3OP DM4M3OP DN C[L-Phe-D-pro-L-Tyr(OMe)-D-trp] DM4M3OP MI TTQW87Y DM4M3OP MN Opioid receptor kappa (OPRK1) DM4M3OP MT DTT DM4M3OP MA Inhibitor DM4M3OP RN Nascent structure-activity relationship study of a diastereomeric series of kappa opioid receptor antagonists derived from CJ-15,208. Bioorg Med Chem Lett. 2009 Jul 1;19(13):3647-50. DM4M3OP RU https://pubmed.ncbi.nlm.nih.gov/19464172 DM4M3OP DI DM4M3OP DM4M3OP DN C[L-Phe-D-pro-L-Tyr(OMe)-D-trp] DM4M3OP MI TTKWM86 DM4M3OP MN Opioid receptor mu (MOP) DM4M3OP MT DTT DM4M3OP MA Inhibitor DM4M3OP RN Nascent structure-activity relationship study of a diastereomeric series of kappa opioid receptor antagonists derived from CJ-15,208. Bioorg Med Chem Lett. 2009 Jul 1;19(13):3647-50. DM4M3OP RU https://pubmed.ncbi.nlm.nih.gov/19464172 DMADSBT DI DMADSBT DMADSBT DN C[L-Phe-D-pro-L-Tyr-D-trp] DMADSBT MI TTQW87Y DMADSBT MN Opioid receptor kappa (OPRK1) DMADSBT MT DTT DMADSBT MA Inhibitor DMADSBT RN Nascent structure-activity relationship study of a diastereomeric series of kappa opioid receptor antagonists derived from CJ-15,208. Bioorg Med Chem Lett. 2009 Jul 1;19(13):3647-50. DMADSBT RU https://pubmed.ncbi.nlm.nih.gov/19464172 DMADSBT DI DMADSBT DMADSBT DN C[L-Phe-D-pro-L-Tyr-D-trp] DMADSBT MI TTKWM86 DMADSBT MN Opioid receptor mu (MOP) DMADSBT MT DTT DMADSBT MA Inhibitor DMADSBT RN Nascent structure-activity relationship study of a diastereomeric series of kappa opioid receptor antagonists derived from CJ-15,208. Bioorg Med Chem Lett. 2009 Jul 1;19(13):3647-50. DMADSBT RU https://pubmed.ncbi.nlm.nih.gov/19464172 DMLB6UA DI DMLB6UA DMLB6UA DN C[L-Tyr(OMe)-D-pro-L-Phe-D-trp] DMLB6UA MI TTQW87Y DMLB6UA MN Opioid receptor kappa (OPRK1) DMLB6UA MT DTT DMLB6UA MA Inhibitor DMLB6UA RN Nascent structure-activity relationship study of a diastereomeric series of kappa opioid receptor antagonists derived from CJ-15,208. Bioorg Med Chem Lett. 2009 Jul 1;19(13):3647-50. DMLB6UA RU https://pubmed.ncbi.nlm.nih.gov/19464172 DMLB6UA DI DMLB6UA DMLB6UA DN C[L-Tyr(OMe)-D-pro-L-Phe-D-trp] DMLB6UA MI TTKWM86 DMLB6UA MN Opioid receptor mu (MOP) DMLB6UA MT DTT DMLB6UA MA Inhibitor DMLB6UA RN Nascent structure-activity relationship study of a diastereomeric series of kappa opioid receptor antagonists derived from CJ-15,208. Bioorg Med Chem Lett. 2009 Jul 1;19(13):3647-50. DMLB6UA RU https://pubmed.ncbi.nlm.nih.gov/19464172 DM7OIY8 DI DM7OIY8 DM7OIY8 DN C[L-Tyr-D-pro-L-Phe-D-trp] DM7OIY8 MI TTQW87Y DM7OIY8 MN Opioid receptor kappa (OPRK1) DM7OIY8 MT DTT DM7OIY8 MA Inhibitor DM7OIY8 RN Nascent structure-activity relationship study of a diastereomeric series of kappa opioid receptor antagonists derived from CJ-15,208. Bioorg Med Chem Lett. 2009 Jul 1;19(13):3647-50. DM7OIY8 RU https://pubmed.ncbi.nlm.nih.gov/19464172 DM7OIY8 DI DM7OIY8 DM7OIY8 DN C[L-Tyr-D-pro-L-Phe-D-trp] DM7OIY8 MI TTKWM86 DM7OIY8 MN Opioid receptor mu (MOP) DM7OIY8 MT DTT DM7OIY8 MA Inhibitor DM7OIY8 RN Nascent structure-activity relationship study of a diastereomeric series of kappa opioid receptor antagonists derived from CJ-15,208. Bioorg Med Chem Lett. 2009 Jul 1;19(13):3647-50. DM7OIY8 RU https://pubmed.ncbi.nlm.nih.gov/19464172 DMX7IVO DI DMX7IVO DMX7IVO DN C[Nle-Arg-D-Nal(2')-Arg-Trp-Glu]-NH2 DMX7IVO MI TTEOSZT DMX7IVO MN Melanocortin receptor (MCR) DMX7IVO MT DTT DMX7IVO MA Inhibitor DMX7IVO RN Development of cyclic gamma-MSH analogues with selective hMC3R agonist and hMC3R/hMC5R antagonist activities. J Med Chem. 2006 Mar 23;49(6):1946-52. DMX7IVO RU https://pubmed.ncbi.nlm.nih.gov/16539382 DMX7IVO DI DMX7IVO DMX7IVO DN C[Nle-Arg-D-Nal(2')-Arg-Trp-Glu]-NH2 DMX7IVO MI TT0MV2T DMX7IVO MN Melanocortin receptor 1 (MC1R) DMX7IVO MT DTT DMX7IVO MA Inhibitor DMX7IVO RN Development of cyclic gamma-MSH analogues with selective hMC3R agonist and hMC3R/hMC5R antagonist activities. J Med Chem. 2006 Mar 23;49(6):1946-52. DMX7IVO RU https://pubmed.ncbi.nlm.nih.gov/16539382 DMX7IVO DI DMX7IVO DMX7IVO DN C[Nle-Arg-D-Nal(2')-Arg-Trp-Glu]-NH2 DMX7IVO MI TTNI91K DMX7IVO MN Melanocortin receptor 3 (MC3R) DMX7IVO MT DTT DMX7IVO MA Inhibitor DMX7IVO RN Development of cyclic gamma-MSH analogues with selective hMC3R agonist and hMC3R/hMC5R antagonist activities. J Med Chem. 2006 Mar 23;49(6):1946-52. DMX7IVO RU https://pubmed.ncbi.nlm.nih.gov/16539382 DMX7IVO DI DMX7IVO DMX7IVO DN C[Nle-Arg-D-Nal(2')-Arg-Trp-Glu]-NH2 DMX7IVO MI TTD0CIQ DMX7IVO MN Melanocortin receptor 4 (MC4R) DMX7IVO MT DTT DMX7IVO MA Inhibitor DMX7IVO RN Development of cyclic gamma-MSH analogues with selective hMC3R agonist and hMC3R/hMC5R antagonist activities. J Med Chem. 2006 Mar 23;49(6):1946-52. DMX7IVO RU https://pubmed.ncbi.nlm.nih.gov/16539382 DMUESCH DI DMUESCH DMUESCH DN C[Nle-Arg-D-Phe-Arg-Trp-Glu]-NH2 DMUESCH MI TTEOSZT DMUESCH MN Melanocortin receptor (MCR) DMUESCH MT DTT DMUESCH MA Inhibitor DMUESCH RN Development of cyclic gamma-MSH analogues with selective hMC3R agonist and hMC3R/hMC5R antagonist activities. J Med Chem. 2006 Mar 23;49(6):1946-52. DMUESCH RU https://pubmed.ncbi.nlm.nih.gov/16539382 DMUESCH DI DMUESCH DMUESCH DN C[Nle-Arg-D-Phe-Arg-Trp-Glu]-NH2 DMUESCH MI TT0MV2T DMUESCH MN Melanocortin receptor 1 (MC1R) DMUESCH MT DTT DMUESCH MA Inhibitor DMUESCH RN Development of cyclic gamma-MSH analogues with selective hMC3R agonist and hMC3R/hMC5R antagonist activities. J Med Chem. 2006 Mar 23;49(6):1946-52. DMUESCH RU https://pubmed.ncbi.nlm.nih.gov/16539382 DMUESCH DI DMUESCH DMUESCH DN C[Nle-Arg-D-Phe-Arg-Trp-Glu]-NH2 DMUESCH MI TTNI91K DMUESCH MN Melanocortin receptor 3 (MC3R) DMUESCH MT DTT DMUESCH MA Inhibitor DMUESCH RN Development of cyclic gamma-MSH analogues with selective hMC3R agonist and hMC3R/hMC5R antagonist activities. J Med Chem. 2006 Mar 23;49(6):1946-52. DMUESCH RU https://pubmed.ncbi.nlm.nih.gov/16539382 DMUESCH DI DMUESCH DMUESCH DN C[Nle-Arg-D-Phe-Arg-Trp-Glu]-NH2 DMUESCH MI TTD0CIQ DMUESCH MN Melanocortin receptor 4 (MC4R) DMUESCH MT DTT DMUESCH MA Inhibitor DMUESCH RN Development of cyclic gamma-MSH analogues with selective hMC3R agonist and hMC3R/hMC5R antagonist activities. J Med Chem. 2006 Mar 23;49(6):1946-52. DMUESCH RU https://pubmed.ncbi.nlm.nih.gov/16539382 DM8SXLR DI DM8SXLR DM8SXLR DN C[Nle-Asp-D-Nal(2')-Arg-Trp-Glu]-NH2 DM8SXLR MI TTEOSZT DM8SXLR MN Melanocortin receptor (MCR) DM8SXLR MT DTT DM8SXLR MA Inhibitor DM8SXLR RN Development of cyclic gamma-MSH analogues with selective hMC3R agonist and hMC3R/hMC5R antagonist activities. J Med Chem. 2006 Mar 23;49(6):1946-52. DM8SXLR RU https://pubmed.ncbi.nlm.nih.gov/16539382 DM8SXLR DI DM8SXLR DM8SXLR DN C[Nle-Asp-D-Nal(2')-Arg-Trp-Glu]-NH2 DM8SXLR MI TTNI91K DM8SXLR MN Melanocortin receptor 3 (MC3R) DM8SXLR MT DTT DM8SXLR MA Inhibitor DM8SXLR RN Development of cyclic gamma-MSH analogues with selective hMC3R agonist and hMC3R/hMC5R antagonist activities. J Med Chem. 2006 Mar 23;49(6):1946-52. DM8SXLR RU https://pubmed.ncbi.nlm.nih.gov/16539382 DM8SXLR DI DM8SXLR DM8SXLR DN C[Nle-Asp-D-Nal(2')-Arg-Trp-Glu]-NH2 DM8SXLR MI TTD0CIQ DM8SXLR MN Melanocortin receptor 4 (MC4R) DM8SXLR MT DTT DM8SXLR MA Inhibitor DM8SXLR RN Development of cyclic gamma-MSH analogues with selective hMC3R agonist and hMC3R/hMC5R antagonist activities. J Med Chem. 2006 Mar 23;49(6):1946-52. DM8SXLR RU https://pubmed.ncbi.nlm.nih.gov/16539382 DMXJAOI DI DMXJAOI DMXJAOI DN C[Nle-Asp-D-Phe-Arg-Trp-Glu]-NH2 DMXJAOI MI TTD0CIQ DMXJAOI MN Melanocortin receptor 4 (MC4R) DMXJAOI MT DTT DMXJAOI MA Inhibitor DMXJAOI RN Development of cyclic gamma-MSH analogues with selective hMC3R agonist and hMC3R/hMC5R antagonist activities. J Med Chem. 2006 Mar 23;49(6):1946-52. DMXJAOI RU https://pubmed.ncbi.nlm.nih.gov/16539382 DMM19SJ DI DMM19SJ DMM19SJ DN C[Nle-Gln-D-Nal(2')-Arg-Trp-Glu]-NH2 DMM19SJ MI TTEOSZT DMM19SJ MN Melanocortin receptor (MCR) DMM19SJ MT DTT DMM19SJ MA Inhibitor DMM19SJ RN Development of cyclic gamma-MSH analogues with selective hMC3R agonist and hMC3R/hMC5R antagonist activities. J Med Chem. 2006 Mar 23;49(6):1946-52. DMM19SJ RU https://pubmed.ncbi.nlm.nih.gov/16539382 DMM19SJ DI DMM19SJ DMM19SJ DN C[Nle-Gln-D-Nal(2')-Arg-Trp-Glu]-NH2 DMM19SJ MI TT0MV2T DMM19SJ MN Melanocortin receptor 1 (MC1R) DMM19SJ MT DTT DMM19SJ MA Inhibitor DMM19SJ RN Development of cyclic gamma-MSH analogues with selective hMC3R agonist and hMC3R/hMC5R antagonist activities. J Med Chem. 2006 Mar 23;49(6):1946-52. DMM19SJ RU https://pubmed.ncbi.nlm.nih.gov/16539382 DMM19SJ DI DMM19SJ DMM19SJ DN C[Nle-Gln-D-Nal(2')-Arg-Trp-Glu]-NH2 DMM19SJ MI TTNI91K DMM19SJ MN Melanocortin receptor 3 (MC3R) DMM19SJ MT DTT DMM19SJ MA Inhibitor DMM19SJ RN Development of cyclic gamma-MSH analogues with selective hMC3R agonist and hMC3R/hMC5R antagonist activities. J Med Chem. 2006 Mar 23;49(6):1946-52. DMM19SJ RU https://pubmed.ncbi.nlm.nih.gov/16539382 DMM19SJ DI DMM19SJ DMM19SJ DN C[Nle-Gln-D-Nal(2')-Arg-Trp-Glu]-NH2 DMM19SJ MI TTD0CIQ DMM19SJ MN Melanocortin receptor 4 (MC4R) DMM19SJ MT DTT DMM19SJ MA Inhibitor DMM19SJ RN Development of cyclic gamma-MSH analogues with selective hMC3R agonist and hMC3R/hMC5R antagonist activities. J Med Chem. 2006 Mar 23;49(6):1946-52. DMM19SJ RU https://pubmed.ncbi.nlm.nih.gov/16539382 DMSGWZE DI DMSGWZE DMSGWZE DN C[Nle-Gln-D-Phe-Arg-Trp-Glu]-NH2 DMSGWZE MI TTEOSZT DMSGWZE MN Melanocortin receptor (MCR) DMSGWZE MT DTT DMSGWZE MA Inhibitor DMSGWZE RN Development of cyclic gamma-MSH analogues with selective hMC3R agonist and hMC3R/hMC5R antagonist activities. J Med Chem. 2006 Mar 23;49(6):1946-52. DMSGWZE RU https://pubmed.ncbi.nlm.nih.gov/16539382 DMSGWZE DI DMSGWZE DMSGWZE DN C[Nle-Gln-D-Phe-Arg-Trp-Glu]-NH2 DMSGWZE MI TT0MV2T DMSGWZE MN Melanocortin receptor 1 (MC1R) DMSGWZE MT DTT DMSGWZE MA Inhibitor DMSGWZE RN Development of cyclic gamma-MSH analogues with selective hMC3R agonist and hMC3R/hMC5R antagonist activities. J Med Chem. 2006 Mar 23;49(6):1946-52. DMSGWZE RU https://pubmed.ncbi.nlm.nih.gov/16539382 DMSGWZE DI DMSGWZE DMSGWZE DN C[Nle-Gln-D-Phe-Arg-Trp-Glu]-NH2 DMSGWZE MI TTNI91K DMSGWZE MN Melanocortin receptor 3 (MC3R) DMSGWZE MT DTT DMSGWZE MA Inhibitor DMSGWZE RN Development of cyclic gamma-MSH analogues with selective hMC3R agonist and hMC3R/hMC5R antagonist activities. J Med Chem. 2006 Mar 23;49(6):1946-52. DMSGWZE RU https://pubmed.ncbi.nlm.nih.gov/16539382 DMHNCAG DI DMHNCAG DMHNCAG DN C[Nle-Glu-D-Nal(2')-Arg-Trp-Glu]-NH2 DMHNCAG MI TTEOSZT DMHNCAG MN Melanocortin receptor (MCR) DMHNCAG MT DTT DMHNCAG MA Inhibitor DMHNCAG RN Development of cyclic gamma-MSH analogues with selective hMC3R agonist and hMC3R/hMC5R antagonist activities. J Med Chem. 2006 Mar 23;49(6):1946-52. DMHNCAG RU https://pubmed.ncbi.nlm.nih.gov/16539382 DMHNCAG DI DMHNCAG DMHNCAG DN C[Nle-Glu-D-Nal(2')-Arg-Trp-Glu]-NH2 DMHNCAG MI TTNI91K DMHNCAG MN Melanocortin receptor 3 (MC3R) DMHNCAG MT DTT DMHNCAG MA Inhibitor DMHNCAG RN Development of cyclic gamma-MSH analogues with selective hMC3R agonist and hMC3R/hMC5R antagonist activities. J Med Chem. 2006 Mar 23;49(6):1946-52. DMHNCAG RU https://pubmed.ncbi.nlm.nih.gov/16539382 DMHNCAG DI DMHNCAG DMHNCAG DN C[Nle-Glu-D-Nal(2')-Arg-Trp-Glu]-NH2 DMHNCAG MI TTD0CIQ DMHNCAG MN Melanocortin receptor 4 (MC4R) DMHNCAG MT DTT DMHNCAG MA Inhibitor DMHNCAG RN Development of cyclic gamma-MSH analogues with selective hMC3R agonist and hMC3R/hMC5R antagonist activities. J Med Chem. 2006 Mar 23;49(6):1946-52. DMHNCAG RU https://pubmed.ncbi.nlm.nih.gov/16539382 DMVWOPG DI DMVWOPG DMVWOPG DN C[Nle-Glu-D-Phe-Arg-Trp-Glu]-NH2 DMVWOPG MI TTEOSZT DMVWOPG MN Melanocortin receptor (MCR) DMVWOPG MT DTT DMVWOPG MA Inhibitor DMVWOPG RN Development of cyclic gamma-MSH analogues with selective hMC3R agonist and hMC3R/hMC5R antagonist activities. J Med Chem. 2006 Mar 23;49(6):1946-52. DMVWOPG RU https://pubmed.ncbi.nlm.nih.gov/16539382 DMVWOPG DI DMVWOPG DMVWOPG DN C[Nle-Glu-D-Phe-Arg-Trp-Glu]-NH2 DMVWOPG MI TTNI91K DMVWOPG MN Melanocortin receptor 3 (MC3R) DMVWOPG MT DTT DMVWOPG MA Inhibitor DMVWOPG RN Development of cyclic gamma-MSH analogues with selective hMC3R agonist and hMC3R/hMC5R antagonist activities. J Med Chem. 2006 Mar 23;49(6):1946-52. DMVWOPG RU https://pubmed.ncbi.nlm.nih.gov/16539382 DM36HBK DI DM36HBK DM36HBK DN C[Nle-His-D-Nal(2')-Arg-Trp-Glu]-NH2 DM36HBK MI TTEOSZT DM36HBK MN Melanocortin receptor (MCR) DM36HBK MT DTT DM36HBK MA Inhibitor DM36HBK RN Development of cyclic gamma-MSH analogues with selective hMC3R agonist and hMC3R/hMC5R antagonist activities. J Med Chem. 2006 Mar 23;49(6):1946-52. DM36HBK RU https://pubmed.ncbi.nlm.nih.gov/16539382 DM36HBK DI DM36HBK DM36HBK DN C[Nle-His-D-Nal(2')-Arg-Trp-Glu]-NH2 DM36HBK MI TTNI91K DM36HBK MN Melanocortin receptor 3 (MC3R) DM36HBK MT DTT DM36HBK MA Inhibitor DM36HBK RN Development of cyclic gamma-MSH analogues with selective hMC3R agonist and hMC3R/hMC5R antagonist activities. J Med Chem. 2006 Mar 23;49(6):1946-52. DM36HBK RU https://pubmed.ncbi.nlm.nih.gov/16539382 DM36HBK DI DM36HBK DM36HBK DN C[Nle-His-D-Nal(2')-Arg-Trp-Glu]-NH2 DM36HBK MI TTD0CIQ DM36HBK MN Melanocortin receptor 4 (MC4R) DM36HBK MT DTT DM36HBK MA Inhibitor DM36HBK RN Development of cyclic gamma-MSH analogues with selective hMC3R agonist and hMC3R/hMC5R antagonist activities. J Med Chem. 2006 Mar 23;49(6):1946-52. DM36HBK RU https://pubmed.ncbi.nlm.nih.gov/16539382 DM5HRNM DI DM5HRNM DM5HRNM DN C[Nle-His-D-Phe-Arg-Trp-Glu]-NH2 DM5HRNM MI TTEOSZT DM5HRNM MN Melanocortin receptor (MCR) DM5HRNM MT DTT DM5HRNM MA Inhibitor DM5HRNM RN Development of cyclic gamma-MSH analogues with selective hMC3R agonist and hMC3R/hMC5R antagonist activities. J Med Chem. 2006 Mar 23;49(6):1946-52. DM5HRNM RU https://pubmed.ncbi.nlm.nih.gov/16539382 DM5HRNM DI DM5HRNM DM5HRNM DN C[Nle-His-D-Phe-Arg-Trp-Glu]-NH2 DM5HRNM MI TTNI91K DM5HRNM MN Melanocortin receptor 3 (MC3R) DM5HRNM MT DTT DM5HRNM MA Inhibitor DM5HRNM RN Development of cyclic gamma-MSH analogues with selective hMC3R agonist and hMC3R/hMC5R antagonist activities. J Med Chem. 2006 Mar 23;49(6):1946-52. DM5HRNM RU https://pubmed.ncbi.nlm.nih.gov/16539382 DM5HRNM DI DM5HRNM DM5HRNM DN C[Nle-His-D-Phe-Arg-Trp-Glu]-NH2 DM5HRNM MI TTD0CIQ DM5HRNM MN Melanocortin receptor 4 (MC4R) DM5HRNM MT DTT DM5HRNM MA Inhibitor DM5HRNM RN Development of cyclic gamma-MSH analogues with selective hMC3R agonist and hMC3R/hMC5R antagonist activities. J Med Chem. 2006 Mar 23;49(6):1946-52. DM5HRNM RU https://pubmed.ncbi.nlm.nih.gov/16539382 DM73ZMG DI DM73ZMG DM73ZMG DN C[Nle-Nle-D-Nal(2')-Arg-Trp-Glu]-NH2 DM73ZMG MI TTEOSZT DM73ZMG MN Melanocortin receptor (MCR) DM73ZMG MT DTT DM73ZMG MA Inhibitor DM73ZMG RN Development of cyclic gamma-MSH analogues with selective hMC3R agonist and hMC3R/hMC5R antagonist activities. J Med Chem. 2006 Mar 23;49(6):1946-52. DM73ZMG RU https://pubmed.ncbi.nlm.nih.gov/16539382 DM73ZMG DI DM73ZMG DM73ZMG DN C[Nle-Nle-D-Nal(2')-Arg-Trp-Glu]-NH2 DM73ZMG MI TT0MV2T DM73ZMG MN Melanocortin receptor 1 (MC1R) DM73ZMG MT DTT DM73ZMG MA Inhibitor DM73ZMG RN Development of cyclic gamma-MSH analogues with selective hMC3R agonist and hMC3R/hMC5R antagonist activities. J Med Chem. 2006 Mar 23;49(6):1946-52. DM73ZMG RU https://pubmed.ncbi.nlm.nih.gov/16539382 DM73ZMG DI DM73ZMG DM73ZMG DN C[Nle-Nle-D-Nal(2')-Arg-Trp-Glu]-NH2 DM73ZMG MI TTNI91K DM73ZMG MN Melanocortin receptor 3 (MC3R) DM73ZMG MT DTT DM73ZMG MA Inhibitor DM73ZMG RN Development of cyclic gamma-MSH analogues with selective hMC3R agonist and hMC3R/hMC5R antagonist activities. J Med Chem. 2006 Mar 23;49(6):1946-52. DM73ZMG RU https://pubmed.ncbi.nlm.nih.gov/16539382 DM73ZMG DI DM73ZMG DM73ZMG DN C[Nle-Nle-D-Nal(2')-Arg-Trp-Glu]-NH2 DM73ZMG MI TTD0CIQ DM73ZMG MN Melanocortin receptor 4 (MC4R) DM73ZMG MT DTT DM73ZMG MA Inhibitor DM73ZMG RN Development of cyclic gamma-MSH analogues with selective hMC3R agonist and hMC3R/hMC5R antagonist activities. J Med Chem. 2006 Mar 23;49(6):1946-52. DM73ZMG RU https://pubmed.ncbi.nlm.nih.gov/16539382 DMDPBVS DI DMDPBVS DMDPBVS DN C[Nle-Nle-D-Phe-Arg-Trp-Glu]-NH2 DMDPBVS MI TTEOSZT DMDPBVS MN Melanocortin receptor (MCR) DMDPBVS MT DTT DMDPBVS MA Inhibitor DMDPBVS RN Development of cyclic gamma-MSH analogues with selective hMC3R agonist and hMC3R/hMC5R antagonist activities. J Med Chem. 2006 Mar 23;49(6):1946-52. DMDPBVS RU https://pubmed.ncbi.nlm.nih.gov/16539382 DMDPBVS DI DMDPBVS DMDPBVS DN C[Nle-Nle-D-Phe-Arg-Trp-Glu]-NH2 DMDPBVS MI TTNI91K DMDPBVS MN Melanocortin receptor 3 (MC3R) DMDPBVS MT DTT DMDPBVS MA Inhibitor DMDPBVS RN Development of cyclic gamma-MSH analogues with selective hMC3R agonist and hMC3R/hMC5R antagonist activities. J Med Chem. 2006 Mar 23;49(6):1946-52. DMDPBVS RU https://pubmed.ncbi.nlm.nih.gov/16539382 DMDPBVS DI DMDPBVS DMDPBVS DN C[Nle-Nle-D-Phe-Arg-Trp-Glu]-NH2 DMDPBVS MI TTD0CIQ DMDPBVS MN Melanocortin receptor 4 (MC4R) DMDPBVS MT DTT DMDPBVS MA Inhibitor DMDPBVS RN Development of cyclic gamma-MSH analogues with selective hMC3R agonist and hMC3R/hMC5R antagonist activities. J Med Chem. 2006 Mar 23;49(6):1946-52. DMDPBVS RU https://pubmed.ncbi.nlm.nih.gov/16539382 DMPZ4VB DI DMPZ4VB DMPZ4VB DN C[Nle-Pro-D-Nal(2')-Arg-Trp-Glu]-NH2 DMPZ4VB MI TTEOSZT DMPZ4VB MN Melanocortin receptor (MCR) DMPZ4VB MT DTT DMPZ4VB MA Inhibitor DMPZ4VB RN Development of cyclic gamma-MSH analogues with selective hMC3R agonist and hMC3R/hMC5R antagonist activities. J Med Chem. 2006 Mar 23;49(6):1946-52. DMPZ4VB RU https://pubmed.ncbi.nlm.nih.gov/16539382 DMPZ4VB DI DMPZ4VB DMPZ4VB DN C[Nle-Pro-D-Nal(2')-Arg-Trp-Glu]-NH2 DMPZ4VB MI TTNI91K DMPZ4VB MN Melanocortin receptor 3 (MC3R) DMPZ4VB MT DTT DMPZ4VB MA Inhibitor DMPZ4VB RN Development of cyclic gamma-MSH analogues with selective hMC3R agonist and hMC3R/hMC5R antagonist activities. J Med Chem. 2006 Mar 23;49(6):1946-52. DMPZ4VB RU https://pubmed.ncbi.nlm.nih.gov/16539382 DMPZ4VB DI DMPZ4VB DMPZ4VB DN C[Nle-Pro-D-Nal(2')-Arg-Trp-Glu]-NH2 DMPZ4VB MI TTD0CIQ DMPZ4VB MN Melanocortin receptor 4 (MC4R) DMPZ4VB MT DTT DMPZ4VB MA Inhibitor DMPZ4VB RN Development of cyclic gamma-MSH analogues with selective hMC3R agonist and hMC3R/hMC5R antagonist activities. J Med Chem. 2006 Mar 23;49(6):1946-52. DMPZ4VB RU https://pubmed.ncbi.nlm.nih.gov/16539382 DMZWMV0 DI DMZWMV0 DMZWMV0 DN C[Nle-Pro-D-Phe-Arg-Trp-Glu]-NH2 DMZWMV0 MI TTEOSZT DMZWMV0 MN Melanocortin receptor (MCR) DMZWMV0 MT DTT DMZWMV0 MA Inhibitor DMZWMV0 RN Development of cyclic gamma-MSH analogues with selective hMC3R agonist and hMC3R/hMC5R antagonist activities. J Med Chem. 2006 Mar 23;49(6):1946-52. DMZWMV0 RU https://pubmed.ncbi.nlm.nih.gov/16539382 DMZWMV0 DI DMZWMV0 DMZWMV0 DN C[Nle-Pro-D-Phe-Arg-Trp-Glu]-NH2 DMZWMV0 MI TTNI91K DMZWMV0 MN Melanocortin receptor 3 (MC3R) DMZWMV0 MT DTT DMZWMV0 MA Inhibitor DMZWMV0 RN Development of cyclic gamma-MSH analogues with selective hMC3R agonist and hMC3R/hMC5R antagonist activities. J Med Chem. 2006 Mar 23;49(6):1946-52. DMZWMV0 RU https://pubmed.ncbi.nlm.nih.gov/16539382 DMZWMV0 DI DMZWMV0 DMZWMV0 DN C[Nle-Pro-D-Phe-Arg-Trp-Glu]-NH2 DMZWMV0 MI TTD0CIQ DMZWMV0 MN Melanocortin receptor 4 (MC4R) DMZWMV0 MT DTT DMZWMV0 MA Inhibitor DMZWMV0 RN Development of cyclic gamma-MSH analogues with selective hMC3R agonist and hMC3R/hMC5R antagonist activities. J Med Chem. 2006 Mar 23;49(6):1946-52. DMZWMV0 RU https://pubmed.ncbi.nlm.nih.gov/16539382 DMSIGJW DI DMSIGJW DMSIGJW DN C[Nle-Val-D-Nal(2')-Arg-Trp-Glu]-NH2 DMSIGJW MI TTEOSZT DMSIGJW MN Melanocortin receptor (MCR) DMSIGJW MT DTT DMSIGJW MA Inhibitor DMSIGJW RN Development of cyclic gamma-MSH analogues with selective hMC3R agonist and hMC3R/hMC5R antagonist activities. J Med Chem. 2006 Mar 23;49(6):1946-52. DMSIGJW RU https://pubmed.ncbi.nlm.nih.gov/16539382 DMSIGJW DI DMSIGJW DMSIGJW DN C[Nle-Val-D-Nal(2')-Arg-Trp-Glu]-NH2 DMSIGJW MI TT0MV2T DMSIGJW MN Melanocortin receptor 1 (MC1R) DMSIGJW MT DTT DMSIGJW MA Inhibitor DMSIGJW RN Development of cyclic gamma-MSH analogues with selective hMC3R agonist and hMC3R/hMC5R antagonist activities. J Med Chem. 2006 Mar 23;49(6):1946-52. DMSIGJW RU https://pubmed.ncbi.nlm.nih.gov/16539382 DMSIGJW DI DMSIGJW DMSIGJW DN C[Nle-Val-D-Nal(2')-Arg-Trp-Glu]-NH2 DMSIGJW MI TTNI91K DMSIGJW MN Melanocortin receptor 3 (MC3R) DMSIGJW MT DTT DMSIGJW MA Inhibitor DMSIGJW RN Development of cyclic gamma-MSH analogues with selective hMC3R agonist and hMC3R/hMC5R antagonist activities. J Med Chem. 2006 Mar 23;49(6):1946-52. DMSIGJW RU https://pubmed.ncbi.nlm.nih.gov/16539382 DMSIGJW DI DMSIGJW DMSIGJW DN C[Nle-Val-D-Nal(2')-Arg-Trp-Glu]-NH2 DMSIGJW MI TTD0CIQ DMSIGJW MN Melanocortin receptor 4 (MC4R) DMSIGJW MT DTT DMSIGJW MA Inhibitor DMSIGJW RN Development of cyclic gamma-MSH analogues with selective hMC3R agonist and hMC3R/hMC5R antagonist activities. J Med Chem. 2006 Mar 23;49(6):1946-52. DMSIGJW RU https://pubmed.ncbi.nlm.nih.gov/16539382 DM45ZLW DI DM45ZLW DM45ZLW DN C[Nle-Val-D-Phe-Arg-Trp-Glu]-NH2 DM45ZLW MI TTEOSZT DM45ZLW MN Melanocortin receptor (MCR) DM45ZLW MT DTT DM45ZLW MA Inhibitor DM45ZLW RN Development of cyclic gamma-MSH analogues with selective hMC3R agonist and hMC3R/hMC5R antagonist activities. J Med Chem. 2006 Mar 23;49(6):1946-52. DM45ZLW RU https://pubmed.ncbi.nlm.nih.gov/16539382 DM45ZLW DI DM45ZLW DM45ZLW DN C[Nle-Val-D-Phe-Arg-Trp-Glu]-NH2 DM45ZLW MI TTNI91K DM45ZLW MN Melanocortin receptor 3 (MC3R) DM45ZLW MT DTT DM45ZLW MA Inhibitor DM45ZLW RN Development of cyclic gamma-MSH analogues with selective hMC3R agonist and hMC3R/hMC5R antagonist activities. J Med Chem. 2006 Mar 23;49(6):1946-52. DM45ZLW RU https://pubmed.ncbi.nlm.nih.gov/16539382 DM45ZLW DI DM45ZLW DM45ZLW DN C[Nle-Val-D-Phe-Arg-Trp-Glu]-NH2 DM45ZLW MI TTD0CIQ DM45ZLW MN Melanocortin receptor 4 (MC4R) DM45ZLW MT DTT DM45ZLW MA Inhibitor DM45ZLW RN Development of cyclic gamma-MSH analogues with selective hMC3R agonist and hMC3R/hMC5R antagonist activities. J Med Chem. 2006 Mar 23;49(6):1946-52. DM45ZLW RU https://pubmed.ncbi.nlm.nih.gov/16539382 DMF091Y DI DMF091Y DMF091Y DN C[RGD-(R)-alpha-TfmfV] DMF091Y MI TTT1R2L DMF091Y MN Integrin alpha-V (ITGAV) DMF091Y MT DTT DMF091Y MA Inhibitor DMF091Y RN Incorporation of the unusual C(alpha)-fluoroalkylamino acids into cyclopeptides: synthesis of arginine-glycine-aspartate (RGD) analogues and study ... J Med Chem. 2006 Mar 9;49(5):1808-17. DMF091Y RU https://pubmed.ncbi.nlm.nih.gov/16509596 DMF091Y DI DMF091Y DMF091Y DN C[RGD-(R)-alpha-TfmfV] DMF091Y MI TTJA1ZO DMF091Y MN ITGB3 messenger RNA (ITGB3 mRNA) DMF091Y MT DTT DMF091Y MA Inhibitor DMF091Y RN Incorporation of the unusual C(alpha)-fluoroalkylamino acids into cyclopeptides: synthesis of arginine-glycine-aspartate (RGD) analogues and study ... J Med Chem. 2006 Mar 9;49(5):1808-17. DMF091Y RU https://pubmed.ncbi.nlm.nih.gov/16509596 DMC9G2Y DI DMC9G2Y DMC9G2Y DN C[RGD-(S)-alpha-TfmfV] DMC9G2Y MI TTT1R2L DMC9G2Y MN Integrin alpha-V (ITGAV) DMC9G2Y MT DTT DMC9G2Y MA Inhibitor DMC9G2Y RN Incorporation of the unusual C(alpha)-fluoroalkylamino acids into cyclopeptides: synthesis of arginine-glycine-aspartate (RGD) analogues and study ... J Med Chem. 2006 Mar 9;49(5):1808-17. DMC9G2Y RU https://pubmed.ncbi.nlm.nih.gov/16509596 DMC9G2Y DI DMC9G2Y DMC9G2Y DN C[RGD-(S)-alpha-TfmfV] DMC9G2Y MI TTJA1ZO DMC9G2Y MN ITGB3 messenger RNA (ITGB3 mRNA) DMC9G2Y MT DTT DMC9G2Y MA Inhibitor DMC9G2Y RN Incorporation of the unusual C(alpha)-fluoroalkylamino acids into cyclopeptides: synthesis of arginine-glycine-aspartate (RGD) analogues and study ... J Med Chem. 2006 Mar 9;49(5):1808-17. DMC9G2Y RU https://pubmed.ncbi.nlm.nih.gov/16509596 DM1DMR2 DI DM1DMR2 DM1DMR2 DN C[RGDf-(3R)-Carboxymorpholine] DM1DMR2 MI TTT1R2L DM1DMR2 MN Integrin alpha-V (ITGAV) DM1DMR2 MT DTT DM1DMR2 MA Inhibitor DM1DMR2 RN Morpholine-based RGD-cyclopentapeptides as alphavbeta3/alphavbeta5 integrin ligands: role of configuration towards receptor binding affinity. Bioorg Med Chem. 2009 Feb 15;17(4):1542-9. DM1DMR2 RU https://pubmed.ncbi.nlm.nih.gov/19195898 DM0ULZM DI DM0ULZM DM0ULZM DN C[RGDf-(3S)-Carboxymorpholine] DM0ULZM MI TTT1R2L DM0ULZM MN Integrin alpha-V (ITGAV) DM0ULZM MT DTT DM0ULZM MA Inhibitor DM0ULZM RN Morpholine-based RGD-cyclopentapeptides as alphavbeta3/alphavbeta5 integrin ligands: role of configuration towards receptor binding affinity. Bioorg Med Chem. 2009 Feb 15;17(4):1542-9. DM0ULZM RU https://pubmed.ncbi.nlm.nih.gov/19195898 DMXA0JB DI DMXA0JB DMXA0JB DN C[RGDf-(R)-alpha-TfmF] DMXA0JB MI TTT1R2L DMXA0JB MN Integrin alpha-V (ITGAV) DMXA0JB MT DTT DMXA0JB MA Inhibitor DMXA0JB RN Incorporation of the unusual C(alpha)-fluoroalkylamino acids into cyclopeptides: synthesis of arginine-glycine-aspartate (RGD) analogues and study ... J Med Chem. 2006 Mar 9;49(5):1808-17. DMXA0JB RU https://pubmed.ncbi.nlm.nih.gov/16509596 DMXA0JB DI DMXA0JB DMXA0JB DN C[RGDf-(R)-alpha-TfmF] DMXA0JB MI TTJA1ZO DMXA0JB MN ITGB3 messenger RNA (ITGB3 mRNA) DMXA0JB MT DTT DMXA0JB MA Inhibitor DMXA0JB RN Incorporation of the unusual C(alpha)-fluoroalkylamino acids into cyclopeptides: synthesis of arginine-glycine-aspartate (RGD) analogues and study ... J Med Chem. 2006 Mar 9;49(5):1808-17. DMXA0JB RU https://pubmed.ncbi.nlm.nih.gov/16509596 DM8FGMA DI DM8FGMA DM8FGMA DN C[RGDf-(R)-alpha-TfmV] DM8FGMA MI TTT1R2L DM8FGMA MN Integrin alpha-V (ITGAV) DM8FGMA MT DTT DM8FGMA MA Inhibitor DM8FGMA RN Incorporation of the unusual C(alpha)-fluoroalkylamino acids into cyclopeptides: synthesis of arginine-glycine-aspartate (RGD) analogues and study ... J Med Chem. 2006 Mar 9;49(5):1808-17. DM8FGMA RU https://pubmed.ncbi.nlm.nih.gov/16509596 DM8FGMA DI DM8FGMA DM8FGMA DN C[RGDf-(R)-alpha-TfmV] DM8FGMA MI TTJA1ZO DM8FGMA MN ITGB3 messenger RNA (ITGB3 mRNA) DM8FGMA MT DTT DM8FGMA MA Inhibitor DM8FGMA RN Incorporation of the unusual C(alpha)-fluoroalkylamino acids into cyclopeptides: synthesis of arginine-glycine-aspartate (RGD) analogues and study ... J Med Chem. 2006 Mar 9;49(5):1808-17. DM8FGMA RU https://pubmed.ncbi.nlm.nih.gov/16509596 DM4ZWOD DI DM4ZWOD DM4ZWOD DN C[RGDf-(R)-N-Me-alpha-TfmF] DM4ZWOD MI TTT1R2L DM4ZWOD MN Integrin alpha-V (ITGAV) DM4ZWOD MT DTT DM4ZWOD MA Inhibitor DM4ZWOD RN Incorporation of the unusual C(alpha)-fluoroalkylamino acids into cyclopeptides: synthesis of arginine-glycine-aspartate (RGD) analogues and study ... J Med Chem. 2006 Mar 9;49(5):1808-17. DM4ZWOD RU https://pubmed.ncbi.nlm.nih.gov/16509596 DM4ZWOD DI DM4ZWOD DM4ZWOD DN C[RGDf-(R)-N-Me-alpha-TfmF] DM4ZWOD MI TTJA1ZO DM4ZWOD MN ITGB3 messenger RNA (ITGB3 mRNA) DM4ZWOD MT DTT DM4ZWOD MA Inhibitor DM4ZWOD RN Incorporation of the unusual C(alpha)-fluoroalkylamino acids into cyclopeptides: synthesis of arginine-glycine-aspartate (RGD) analogues and study ... J Med Chem. 2006 Mar 9;49(5):1808-17. DM4ZWOD RU https://pubmed.ncbi.nlm.nih.gov/16509596 DMCXJOL DI DMCXJOL DMCXJOL DN C[RGDf-(S)-alpha-TfmF] DMCXJOL MI TTT1R2L DMCXJOL MN Integrin alpha-V (ITGAV) DMCXJOL MT DTT DMCXJOL MA Inhibitor DMCXJOL RN Incorporation of the unusual C(alpha)-fluoroalkylamino acids into cyclopeptides: synthesis of arginine-glycine-aspartate (RGD) analogues and study ... J Med Chem. 2006 Mar 9;49(5):1808-17. DMCXJOL RU https://pubmed.ncbi.nlm.nih.gov/16509596 DMCXJOL DI DMCXJOL DMCXJOL DN C[RGDf-(S)-alpha-TfmF] DMCXJOL MI TTJA1ZO DMCXJOL MN ITGB3 messenger RNA (ITGB3 mRNA) DMCXJOL MT DTT DMCXJOL MA Inhibitor DMCXJOL RN Incorporation of the unusual C(alpha)-fluoroalkylamino acids into cyclopeptides: synthesis of arginine-glycine-aspartate (RGD) analogues and study ... J Med Chem. 2006 Mar 9;49(5):1808-17. DMCXJOL RU https://pubmed.ncbi.nlm.nih.gov/16509596 DMLRYXK DI DMLRYXK DMLRYXK DN C[RGDf-(S)-alpha-TfmV] DMLRYXK MI TTT1R2L DMLRYXK MN Integrin alpha-V (ITGAV) DMLRYXK MT DTT DMLRYXK MA Inhibitor DMLRYXK RN Incorporation of the unusual C(alpha)-fluoroalkylamino acids into cyclopeptides: synthesis of arginine-glycine-aspartate (RGD) analogues and study ... J Med Chem. 2006 Mar 9;49(5):1808-17. DMLRYXK RU https://pubmed.ncbi.nlm.nih.gov/16509596 DMLRYXK DI DMLRYXK DMLRYXK DN C[RGDf-(S)-alpha-TfmV] DMLRYXK MI TTJA1ZO DMLRYXK MN ITGB3 messenger RNA (ITGB3 mRNA) DMLRYXK MT DTT DMLRYXK MA Inhibitor DMLRYXK RN Incorporation of the unusual C(alpha)-fluoroalkylamino acids into cyclopeptides: synthesis of arginine-glycine-aspartate (RGD) analogues and study ... J Med Chem. 2006 Mar 9;49(5):1808-17. DMLRYXK RU https://pubmed.ncbi.nlm.nih.gov/16509596 DMNS3HC DI DMNS3HC DMNS3HC DN C[RGDf-(S)-N-Me-alpha-TfmF] DMNS3HC MI TTT1R2L DMNS3HC MN Integrin alpha-V (ITGAV) DMNS3HC MT DTT DMNS3HC MA Inhibitor DMNS3HC RN Incorporation of the unusual C(alpha)-fluoroalkylamino acids into cyclopeptides: synthesis of arginine-glycine-aspartate (RGD) analogues and study ... J Med Chem. 2006 Mar 9;49(5):1808-17. DMNS3HC RU https://pubmed.ncbi.nlm.nih.gov/16509596 DMNS3HC DI DMNS3HC DMNS3HC DN C[RGDf-(S)-N-Me-alpha-TfmF] DMNS3HC MI TTJA1ZO DMNS3HC MN ITGB3 messenger RNA (ITGB3 mRNA) DMNS3HC MT DTT DMNS3HC MA Inhibitor DMNS3HC RN Incorporation of the unusual C(alpha)-fluoroalkylamino acids into cyclopeptides: synthesis of arginine-glycine-aspartate (RGD) analogues and study ... J Med Chem. 2006 Mar 9;49(5):1808-17. DMNS3HC RU https://pubmed.ncbi.nlm.nih.gov/16509596 DMAILK8 DI DMAILK8 DMAILK8 DN C[RGDf-(S,R)-alpha-Dfm-F] DMAILK8 MI TTT1R2L DMAILK8 MN Integrin alpha-V (ITGAV) DMAILK8 MT DTT DMAILK8 MA Inhibitor DMAILK8 RN Incorporation of the unusual C(alpha)-fluoroalkylamino acids into cyclopeptides: synthesis of arginine-glycine-aspartate (RGD) analogues and study ... J Med Chem. 2006 Mar 9;49(5):1808-17. DMAILK8 RU https://pubmed.ncbi.nlm.nih.gov/16509596 DMAILK8 DI DMAILK8 DMAILK8 DN C[RGDf-(S,R)-alpha-Dfm-F] DMAILK8 MI TTJA1ZO DMAILK8 MN ITGB3 messenger RNA (ITGB3 mRNA) DMAILK8 MT DTT DMAILK8 MA Inhibitor DMAILK8 RN Incorporation of the unusual C(alpha)-fluoroalkylamino acids into cyclopeptides: synthesis of arginine-glycine-aspartate (RGD) analogues and study ... J Med Chem. 2006 Mar 9;49(5):1808-17. DMAILK8 RU https://pubmed.ncbi.nlm.nih.gov/16509596 DMO7BMZ DI DMO7BMZ DMO7BMZ DN C[Ser-Tyr-Thr-His-Dphe-Arg-Trp-Thr-Ile-Pro] DMO7BMZ MI TTD0CIQ DMO7BMZ MN Melanocortin receptor 4 (MC4R) DMO7BMZ MT DTT DMO7BMZ MA Inhibitor DMO7BMZ RN Mapping the binding site of melanocortin 4 receptor agonists: a hydrophobic pocket formed by I3.28(125), I3.32(129), and I7.42(291) is critical for... J Med Chem. 2006 Feb 9;49(3):911-22. DMO7BMZ RU https://pubmed.ncbi.nlm.nih.gov/16451057 DMRY95I DI DMRY95I DMRY95I DN C[Thr-Tyr-Thr-His-DNaf-Arg-Trp-Thr-Ile-Pro] DMRY95I MI TTD0CIQ DMRY95I MN Melanocortin receptor 4 (MC4R) DMRY95I MT DTT DMRY95I MA Inhibitor DMRY95I RN Mapping the binding site of melanocortin 4 receptor agonists: a hydrophobic pocket formed by I3.28(125), I3.32(129), and I7.42(291) is critical for... J Med Chem. 2006 Feb 9;49(3):911-22. DMRY95I RU https://pubmed.ncbi.nlm.nih.gov/16451057 DM0YLPV DI DM0YLPV DM0YLPV DN C[YYAEGLEE]-NH2 DM0YLPV MI TT1VAUK DM0YLPV MN VEGFR1 messenger RNA (VEGFR1 mRNA) DM0YLPV MT DTT DM0YLPV MA Inhibitor DM0YLPV RN Biochemical and structural analysis of the binding determinants of a vascular endothelial growth factor receptor peptidic antagonist. J Med Chem. 2010 Jun 10;53(11):4428-40. DM0YLPV RU https://pubmed.ncbi.nlm.nih.gov/20462213 DMSKW8H DI DMSKW8H DMSKW8H DN C[YYDEGLEE]-NH2 DMSKW8H MI TT1VAUK DMSKW8H MN VEGFR1 messenger RNA (VEGFR1 mRNA) DMSKW8H MT DTT DMSKW8H MA Inhibitor DMSKW8H RN Biochemical and structural analysis of the binding determinants of a vascular endothelial growth factor receptor peptidic antagonist. J Med Chem. 2010 Jun 10;53(11):4428-40. DMSKW8H RU https://pubmed.ncbi.nlm.nih.gov/20462213 DMTHGMR DI DMTHGMR DMTHGMR DN C[YYDEKLEE]-NH2 DMTHGMR MI TT1VAUK DMTHGMR MN VEGFR1 messenger RNA (VEGFR1 mRNA) DMTHGMR MT DTT DMTHGMR MA Inhibitor DMTHGMR RN Biochemical and structural analysis of the binding determinants of a vascular endothelial growth factor receptor peptidic antagonist. J Med Chem. 2010 Jun 10;53(11):4428-40. DMTHGMR RU https://pubmed.ncbi.nlm.nih.gov/20462213 DMD7OQA DI DMD7OQA DMD7OQA DN C-014C DMD7OQA MI TT7HQD0 DMD7OQA MN C-C chemokine receptor type 4 (CCR4) DMD7OQA MT DTT DMD7OQA MA Inhibitor DMD7OQA RN Discovery of potent CCR4 antagonists: Synthesis and structure-activity relationship study of 2,4-diaminoquinazolines. Bioorg Med Chem. 2008 Jul 15;16(14):7021-32. DMD7OQA RU https://pubmed.ncbi.nlm.nih.gov/18539035 DMNV1ST DI DMNV1ST DMNV1ST DN C-10068 DMNV1ST MI TT5TPI6 DMNV1ST MN Opioid receptor sigma 1 (OPRS1) DMNV1ST MT DTT DMNV1ST MA Agonist DMNV1ST RN Antitussives and substance abuse. Subst Abuse Rehabil. 2013 Nov 6;4:75-82. DMNV1ST RU https://pubmed.ncbi.nlm.nih.gov/24648790 DMZXE6O DI DMZXE6O DMZXE6O DN C-16-(S)-3-methylindolerapamycin DMZXE6O MI TTCJG29 DMZXE6O MN Serine/threonine-protein kinase mTOR (mTOR) DMZXE6O MT DTT DMZXE6O MA Inhibitor DMZXE6O RN The rapamycin-binding domain of the protein kinase mammalian target of rapamycin is a destabilizing domain. J Biol Chem. 2007 May 4;282(18):13395-401. DMZXE6O RU https://pubmed.ncbi.nlm.nih.gov/17350953 DM23KNC DI DM23KNC DM23KNC DN C16-Fatty-Acyl-Substrate-Mimic DM23KNC MI TTVTX4N DM23KNC MN Bacterial Fatty acid synthetase I (Bact inhA) DM23KNC MT DTT DM23KNC MA Inhibitor DM23KNC RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DM23KNC RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMKGSRZ DI DMKGSRZ DMKGSRZ DN C-176 DMKGSRZ MI TTT402Y DMKGSRZ MN Stimulator of interferon genes protein (TMEM173) DMKGSRZ MT DTT DMKGSRZ MA Agonist DMKGSRZ RN Stimulator of IFN genes mediates neuroinflammatory injury by suppressing AMPK signal in experimental subarachnoid hemorrhage. J Neuroinflammation. 2020 May 25;17(1):165. DMKGSRZ RU https://pubmed.ncbi.nlm.nih.gov/32450897 DM4FEU8 DI DM4FEU8 DM4FEU8 DN C-178 DM4FEU8 MI TTT402Y DM4FEU8 MN Stimulator of interferon genes protein (TMEM173) DM4FEU8 MT DTT DM4FEU8 MA Agonist DM4FEU8 RN Targeting STING with covalent small-molecule inhibitors. Nature. 2018 Jul;559(7713):269-273. DM4FEU8 RU https://pubmed.ncbi.nlm.nih.gov/29973723 DMCAO3V DI DMCAO3V DMCAO3V DN C-21191 DMCAO3V MI TTEX6LM DMCAO3V MN GABA(A) receptor gamma-3 (GABRG3) DMCAO3V MT DTT DMCAO3V MA Modulator DMCAO3V RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 415). DMCAO3V RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=415 DMS87IF DI DMS87IF DMS87IF DN C2-MAD DMS87IF MI TTTB4UP DMS87IF MN Inosine-5'-monophosphate dehydrogenase 2 (IMPDH2) DMS87IF MT DTT DMS87IF MA Inhibitor DMS87IF RN Novel mycophenolic adenine bis(phosphonate) analogues as potential differentiation agents against human leukemia. J Med Chem. 2002 Jan 31;45(3):703-12. DMS87IF RU https://pubmed.ncbi.nlm.nih.gov/11806722 DMTCOY9 DI DMTCOY9 DMTCOY9 DN C3 DMTCOY9 MI TTX4RTB DMTCOY9 MN Melanin-concentrating hormone receptor 1 (MCHR1) DMTCOY9 MT DTT DMTCOY9 MA Agonist DMTCOY9 RN SLC-1 receptor mediates effect of melanin-concentrating hormone on feeding behavior in rat: a structure-activity study. J Pharmacol Exp Ther. 2001 Oct;299(1):137-46. DMTCOY9 RU https://pubmed.ncbi.nlm.nih.gov/11561073 DMGA9U7 DI DMGA9U7 DMGA9U7 DN C4-MAD DMGA9U7 MI TTTB4UP DMGA9U7 MN Inosine-5'-monophosphate dehydrogenase 2 (IMPDH2) DMGA9U7 MT DTT DMGA9U7 MA Inhibitor DMGA9U7 RN Novel mycophenolic adenine bis(phosphonate) analogues as potential differentiation agents against human leukemia. J Med Chem. 2002 Jan 31;45(3):703-12. DMGA9U7 RU https://pubmed.ncbi.nlm.nih.gov/11806722 DM5971G DI DM5971G DM5971G DN C4X-101 DM5971G MI TT4J8MF DM5971G MN Thyrotropin-releasing hormone receptor (TRHR) DM5971G MT DTT DM5971G MA Inhibitor DM5971G RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 363). DM5971G RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=363 DMEK4HZ DI DMEK4HZ DMEK4HZ DN C5aR pepducins DMEK4HZ MI TTHXFA1 DMEK4HZ MN C5a anaphylatoxin chemotactic receptor (C5AR1) DMEK4HZ MT DTT DMEK4HZ MA Modulator DMEK4HZ RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 32). DMEK4HZ RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=32 DMCOQKH DI DMCOQKH DMCOQKH DN C646 DMCOQKH MI TTH4VJL DMCOQKH MN Histone acetyltransferase KAT6B (KAT6B) DMCOQKH MT DTT DMCOQKH MA Inhibitor DMCOQKH RN Virtual ligand screening of the p300/CBP histone acetyltransferase: identification of a selective small molecule inhibitor. Chem Biol. 2010 May 28;17(5):471-82. DMCOQKH RU https://pubmed.ncbi.nlm.nih.gov/20534345 DM4LIHQ DI DM4LIHQ DM4LIHQ DN C6S DM4LIHQ MI TTKWM86 DM4LIHQ MN Opioid receptor mu (MOP) DM4LIHQ MT DTT DM4LIHQ MA Inhibitor DM4LIHQ RN Opiate receptor binding properties of morphine-, dihydromorphine-, and codeine 6-O-sulfate ester congeners. Bioorg Med Chem Lett. 2006 Aug 15;16(16):4291-5. DM4LIHQ RU https://pubmed.ncbi.nlm.nih.gov/16777416 DM7MNOX DI DM7MNOX DM7MNOX DN C7/3-phth DM7MNOX MI TTOXS3C DM7MNOX MN Muscarinic acetylcholine receptor (CHRM) DM7MNOX MT DTT DM7MNOX MA Modulator (allosteric modulator) DM7MNOX RN Characterization of the subtype selectivity of the allosteric modulator heptane-1,7-bis-(dimethyl-3'-phthalimidopropyl) ammonium bromide (C7/3-phth) at cloned muscarinic acetylcholine receptors. Biochem Pharmacol. 1999 Jan 15;57(2):171-9. DM7MNOX RU https://pubmed.ncbi.nlm.nih.gov/9890565 DMHGX1N DI DMHGX1N DMHGX1N DN C75 DMHGX1N MI TTDL0NY DMHGX1N MN Carnitine O-palmitoyltransferase I (CPT1B) DMHGX1N MT DTT DMHGX1N MA Activator DMHGX1N RN C75 increases peripheral energy utilization and fatty acid oxidation in diet-induced obesity. Proc Natl Acad Sci U S A. 2002 Jul 9;99(14):9498-502. DMHGX1N RU https://pubmed.ncbi.nlm.nih.gov/12060712 DMHGX1N DI DMHGX1N DMHGX1N DN C75 DMHGX1N MI TT7AOUD DMHGX1N MN Fatty acid synthase (FASN) DMHGX1N MT DTT DMHGX1N MA Inhibitor DMHGX1N RN C75 increases peripheral energy utilization and fatty acid oxidation in diet-induced obesity. Proc Natl Acad Sci U S A. 2002 Jul 9;99(14):9498-502. DMHGX1N RU https://pubmed.ncbi.nlm.nih.gov/12060712 DMX85E7 DI DMX85E7 DMX85E7 DN Ca(2+) chelator DMX85E7 MI TTBLN9S DMX85E7 MN Sulfur mustard-stimulated protease (SMSP) DMX85E7 MT DTT DMX85E7 MA Inhibitor DMX85E7 RN Sulfur mustard-stimulated protease: a target for antivesicant drugs. J Appl Toxicol. 2002 Mar-Apr;22(2):139-40. DMX85E7 RU https://pubmed.ncbi.nlm.nih.gov/11920939 DMP5OSK DI DMP5OSK DMP5OSK DN CA-327 DMP5OSK MI TT8ZLTI DMP5OSK MN Programmed cell death 1 ligand 1 (PD-L1) DMP5OSK MT DTT DMP5OSK MA Inhibitor DMP5OSK RN Development of Inhibitors of the Programmed Cell Death-1/Programmed Cell Death-Ligand 1 Signaling Pathway.J Med Chem. 2019 Feb 28;62(4):1715-1730. DMP5OSK RU https://pubmed.ncbi.nlm.nih.gov/30247903 DMCLN6M DI DMCLN6M DMCLN6M DN CA-50040 DMCLN6M MI TTF1QVM DMCLN6M MN Gastric H(+)/K(+) ATPase alpha (ATP4A) DMCLN6M MT DTT DMCLN6M MA Modulator DMCLN6M RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 849). DMCLN6M RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=849 DMQATPN DI DMQATPN DMQATPN DN CAA0225 DMQATPN MI TT36ETB DMQATPN MN Cathepsin L (CTSL) DMQATPN MT DTT DMQATPN MA Inhibitor DMQATPN RN Characterization of CAA0225, a novel inhibitor specific for cathepsin L, as a probe for autophagic proteolysis. Biol Pharm Bull. 2009 Mar;32(3):475-9. DMQATPN RU https://pubmed.ncbi.nlm.nih.gov/19252298 DMPKFYZ DI DMPKFYZ DMPKFYZ DN CACA DMPKFYZ MI TT6XFEU DMPKFYZ MN GABA(A) receptor rho1 (GABRR1) DMPKFYZ MT DTT DMPKFYZ MA Agonist DMPKFYZ RN Characterization of bicuculline/baclofen-insensitive (rho-like) gamma-aminobutyric acid receptors expressed in Xenopus oocytes. II. Pharmacology of gamma-aminobutyric acidA and gamma-aminobutyric acidB receptor agonists and antagonists. Mol Pharmacol. 1993 Apr;43(4):609-25. DMPKFYZ RU https://pubmed.ncbi.nlm.nih.gov/8386310 DMK4XLD DI DMK4XLD DMK4XLD DN Cacodylate Ion DMK4XLD MI TTQWGU9 DMK4XLD MN Bacterial Aspartate-semialdehyde dehydrogenase (Bact asd2) DMK4XLD MT DTT DMK4XLD MA Inhibitor DMK4XLD RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMK4XLD RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMK4XLD DI DMK4XLD DMK4XLD DN Cacodylate Ion DMK4XLD MI TTV3NH6 DMK4XLD MN Calmodulin (CALM) DMK4XLD MT DTT DMK4XLD MA Inhibitor DMK4XLD RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMK4XLD RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMK4XLD DI DMK4XLD DMK4XLD DN Cacodylate Ion DMK4XLD MI TTCM4B3 DMK4XLD MN Nitric-oxide synthase endothelial (NOS3) DMK4XLD MT DTT DMK4XLD MA Inhibitor DMK4XLD RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMK4XLD RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMK4XLD DI DMK4XLD DMK4XLD DN Cacodylate Ion DMK4XLD MI TT0OFWN DMK4XLD MN Pseudomonas UDP-3-O-acyl-GlcNAc deacetylase (Pseudo lpxC) DMK4XLD MT DTT DMK4XLD MA Inhibitor DMK4XLD RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMK4XLD RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMK4XLD DI DMK4XLD DMK4XLD DN Cacodylate Ion DMK4XLD MI TTZJ5U9 DMK4XLD MN Thioredoxin (TXN) DMK4XLD MT DTT DMK4XLD MA Inhibitor DMK4XLD RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMK4XLD RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMK4XLD DI DMK4XLD DMK4XLD DN Cacodylate Ion DMK4XLD MI TTGER3L DMK4XLD MN Thyroid hormone receptor beta (THRB) DMK4XLD MT DTT DMK4XLD MA Inhibitor DMK4XLD RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMK4XLD RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMIPJUS DI DMIPJUS DMIPJUS DN CACOSPONGIONOLIDE DMIPJUS MI TTO8QRU DMIPJUS MN Group IIA phospholipase A2 (GIIA sPLA2) DMIPJUS MT DTT DMIPJUS MA Inhibitor DMIPJUS RN A new cacospongionolide inhibitor of human secretory phospholipase A2 from the Tyrrhenian sponge Fasciospongia cavernosa and absolute configuration... J Nat Prod. 1998 Jul;61(7):931-5. DMIPJUS RU https://pubmed.ncbi.nlm.nih.gov/9677277 DMIPJUS DI DMIPJUS DMIPJUS DN CACOSPONGIONOLIDE DMIPJUS MI TT9V5JH DMIPJUS MN Phospholipase A2 (PLA2G1B) DMIPJUS MT DTT DMIPJUS MA Inhibitor DMIPJUS RN A new cacospongionolide inhibitor of human secretory phospholipase A2 from the Tyrrhenian sponge Fasciospongia cavernosa and absolute configuration... J Nat Prod. 1998 Jul;61(7):931-5. DMIPJUS RU https://pubmed.ncbi.nlm.nih.gov/9677277 DMCSXNW DI DMCSXNW DMCSXNW DN CACOSPONGIONOLIDE B DMCSXNW MI TTO8QRU DMCSXNW MN Group IIA phospholipase A2 (GIIA sPLA2) DMCSXNW MT DTT DMCSXNW MA Inhibitor DMCSXNW RN A new cacospongionolide inhibitor of human secretory phospholipase A2 from the Tyrrhenian sponge Fasciospongia cavernosa and absolute configuration... J Nat Prod. 1998 Jul;61(7):931-5. DMCSXNW RU https://pubmed.ncbi.nlm.nih.gov/9677277 DMCSXNW DI DMCSXNW DMCSXNW DN CACOSPONGIONOLIDE B DMCSXNW MI TT9V5JH DMCSXNW MN Phospholipase A2 (PLA2G1B) DMCSXNW MT DTT DMCSXNW MA Inhibitor DMCSXNW RN A new cacospongionolide inhibitor of human secretory phospholipase A2 from the Tyrrhenian sponge Fasciospongia cavernosa and absolute configuration... J Nat Prod. 1998 Jul;61(7):931-5. DMCSXNW RU https://pubmed.ncbi.nlm.nih.gov/9677277 DM2DYAV DI DM2DYAV DM2DYAV DN Cacospongionolide E DM2DYAV MI TTO8QRU DM2DYAV MN Group IIA phospholipase A2 (GIIA sPLA2) DM2DYAV MT DTT DM2DYAV MA Inhibitor DM2DYAV RN A new cacospongionolide inhibitor of human secretory phospholipase A2 from the Tyrrhenian sponge Fasciospongia cavernosa and absolute configuration... J Nat Prod. 1998 Jul;61(7):931-5. DM2DYAV RU https://pubmed.ncbi.nlm.nih.gov/9677277 DM2DYAV DI DM2DYAV DM2DYAV DN Cacospongionolide E DM2DYAV MI TT9V5JH DM2DYAV MN Phospholipase A2 (PLA2G1B) DM2DYAV MT DTT DM2DYAV MA Inhibitor DM2DYAV RN A new cacospongionolide inhibitor of human secretory phospholipase A2 from the Tyrrhenian sponge Fasciospongia cavernosa and absolute configuration... J Nat Prod. 1998 Jul;61(7):931-5. DM2DYAV RU https://pubmed.ncbi.nlm.nih.gov/9677277 DMLKZQH DI DMLKZQH DMLKZQH DN cADPR DMLKZQH MI TTEBMN7 DMLKZQH MN Long transient receptor potential channel 2 (TRPM2) DMLKZQH MT DTT DMLKZQH MA Activator DMLKZQH RN Nicotinic acid adenine dinucleotide phosphate and cyclic ADP-ribose regulate TRPM2 channels in T lymphocytes. FASEB J. 2006 May;20(7):962-4. DMLKZQH RU https://pubmed.ncbi.nlm.nih.gov/16585058 DMRJKIV DI DMRJKIV DMRJKIV DN Caffeic acid phenethyl ester DMRJKIV MI DEEZYQV DMRJKIV MN Amylosucrase (AMS) DMRJKIV MT DME DMRJKIV MA Metabolism DMRJKIV RN The complete genome and proteome of Laribacter hongkongensis reveal potential mechanisms for adaptations to different temperatures and habitats. PLoS Genet. 2009 Mar;5(3):e1000416. DMRJKIV RU https://pubmed.ncbi.nlm.nih.gov/19283063 DMRJKIV DI DMRJKIV DMRJKIV DN Caffeic acid phenethyl ester DMRJKIV MI DEEPQJ8 DMRJKIV MN Dextransucrase 1 (dsrF1) DMRJKIV MT DME DMRJKIV MA Metabolism DMRJKIV RN Transglycosylation improved caffeic acid phenethyl ester anti-inflammatory activity and water solubility by Leuconostoc mesenteroides dextransucrase. J Agric Food Chem. 2019 Apr 24;67(16):4505-4512. DMRJKIV RU https://pubmed.ncbi.nlm.nih.gov/30915841 DMRJKIV DI DMRJKIV DMRJKIV DN Caffeic acid phenethyl ester DMRJKIV MI DE174E0 DMRJKIV MN Dextransucrase 2 (dsrF2) DMRJKIV MT DME DMRJKIV MA Metabolism DMRJKIV RN Transglycosylation improved caffeic acid phenethyl ester anti-inflammatory activity and water solubility by Leuconostoc mesenteroides dextransucrase. J Agric Food Chem. 2019 Apr 24;67(16):4505-4512. DMRJKIV RU https://pubmed.ncbi.nlm.nih.gov/30915841 DMRJKIV DI DMRJKIV DMRJKIV DN Caffeic acid phenethyl ester DMRJKIV MI DED68N5 DMRJKIV MN Dextransucrase 3 (dsrF3) DMRJKIV MT DME DMRJKIV MA Metabolism DMRJKIV RN Transglycosylation improved caffeic acid phenethyl ester anti-inflammatory activity and water solubility by Leuconostoc mesenteroides dextransucrase. J Agric Food Chem. 2019 Apr 24;67(16):4505-4512. DMRJKIV RU https://pubmed.ncbi.nlm.nih.gov/30915841 DMRJKIV DI DMRJKIV DMRJKIV DN Caffeic acid phenethyl ester DMRJKIV MI DE1KTC4 DMRJKIV MN Dextransucrase 4 (dsrF4) DMRJKIV MT DME DMRJKIV MA Metabolism DMRJKIV RN Transglycosylation improved caffeic acid phenethyl ester anti-inflammatory activity and water solubility by Leuconostoc mesenteroides dextransucrase. J Agric Food Chem. 2019 Apr 24;67(16):4505-4512. DMRJKIV RU https://pubmed.ncbi.nlm.nih.gov/30915841 DMRJKIV DI DMRJKIV DMRJKIV DN Caffeic acid phenethyl ester DMRJKIV MI TTSXVID DMRJKIV MN Nuclear factor NF-kappa-B (NFKB) DMRJKIV MT DTT DMRJKIV MA Inhibitor DMRJKIV RN Beneficial effects of caffeic acid phenethyl ester in a rat model of vascular injury. Br J Pharmacol. 2002 Jun;136(3):353-60. DMRJKIV RU https://pubmed.ncbi.nlm.nih.gov/12023937 DM6NPUM DI DM6NPUM DM6NPUM DN CALCEOLARIOSIDE A DM6NPUM MI TTFJ8Q1 DM6NPUM MN Protein kinase C alpha (PRKCA) DM6NPUM MT DTT DM6NPUM MA Inhibitor DM6NPUM RN Phenylethanoid glycosides from Digitalis purpurea and Penstemon linarioides with PKCalpha-inhibitory activity. J Nat Prod. 1998 Nov;61(11):1410-2. DM6NPUM RU https://pubmed.ncbi.nlm.nih.gov/9834166 DMEAUK5 DI DMEAUK5 DMEAUK5 DN CALCEOLARIOSIDE B DMEAUK5 MI TTFJ8Q1 DMEAUK5 MN Protein kinase C alpha (PRKCA) DMEAUK5 MT DTT DMEAUK5 MA Inhibitor DMEAUK5 RN Phenylethanoid glycosides from Digitalis purpurea and Penstemon linarioides with PKCalpha-inhibitory activity. J Nat Prod. 1998 Nov;61(11):1410-2. DMEAUK5 RU https://pubmed.ncbi.nlm.nih.gov/9834166 DML562D DI DML562D DML562D DN Calcineurin DML562D MI TTHT87J DML562D MN TWIK-related spinal cord potassium channel (TRESK) DML562D MT DTT DML562D MA Activator DML562D RN TRESK channel as a potential target to treat T-cell mediated immune dysfunction. Biochem Biophys Res Commun. 2009 Dec 25;390(4):1102-5. DML562D RU https://pubmed.ncbi.nlm.nih.gov/19852929 DMZ45M6 DI DMZ45M6 DMZ45M6 DN calcitriol-26,23-lactone DMZ45M6 MI TTK59TV DMZ45M6 MN Vitamin D3 receptor (VDR) DMZ45M6 MT DTT DMZ45M6 MA Agonist DMZ45M6 RN Biological activity of 24,24-difluoro-1 alpha, 25-dihydroxyvitamin D3 and 1 alpha, 25-dihydroxyvitamin D3-26,23-lactone in inducing differentiation of human myeloid leukemia cells. Arch Biochem Biophys. 1983 Jan;220(1):90-4. DMZ45M6 RU https://pubmed.ncbi.nlm.nih.gov/6572492 DMJXZD5 DI DMJXZD5 DMJXZD5 DN calhex 231 DMJXZD5 MI TTBUYHA DMJXZD5 MN Extracellular calcium-sensing receptor (CASR) DMJXZD5 MT DTT DMJXZD5 MA Modulator (allosteric modulator) DMJXZD5 RN Modeling and mutagenesis of the binding site of Calhex 231, a novel negative allosteric modulator of the extracellular Ca(2+)-sensing receptor. J Biol Chem. 2003 Dec 5;278(49):49487-94. DMJXZD5 RU https://pubmed.ncbi.nlm.nih.gov/14506236 DMY9P6E DI DMY9P6E DMY9P6E DN calindol DMY9P6E MI TTBUYHA DMY9P6E MN Extracellular calcium-sensing receptor (CASR) DMY9P6E MT DTT DMY9P6E MA Modulator (allosteric modulator) DMY9P6E RN N2-benzyl-N1-(1-(1-naphthyl)ethyl)-3-phenylpropane-1,2-diamines and conformationally restrained indole analogues: development of calindol as a new calcimimetic acting at the calcium sensing receptor.Bioorg Med Chem Lett. 2004 Jun 21;14(12):3345-9. DMY9P6E RU https://pubmed.ncbi.nlm.nih.gov/15149704 DMY9P6E DI DMY9P6E DMY9P6E DN calindol DMY9P6E MI TTI1PRE DMY9P6E MN G-protein coupled receptor GPCR33 (GPRC6A) DMY9P6E MT DTT DMY9P6E MA Modulator (allosteric modulator) DMY9P6E RN Molecular determinants of non-competitive antagonist binding to the mouse GPRC6A receptor. Cell Calcium. 2009 Nov-Dec;46(5-6):323-32. DMY9P6E RU https://pubmed.ncbi.nlm.nih.gov/19836834 DM5ZTJL DI DM5ZTJL DM5ZTJL DN Calmidazolium DM5ZTJL MI TTV3NH6 DM5ZTJL MN Calmodulin (CALM) DM5ZTJL MT DTT DM5ZTJL MA Inhibitor DM5ZTJL RN Calmidazolium evokes high calcium fluctuations in Plasmodium falciparum. Cell Signal. 2016 Mar;28(3):125-135. DM5ZTJL RU https://pubmed.ncbi.nlm.nih.gov/26689736 DMVXKLF DI DMVXKLF DMVXKLF DN CALOPOCARPIN DMVXKLF MI TT50QJ3 DMVXKLF MN Influenza Neuraminidase (Influ NA) DMVXKLF MT DTT DMVXKLF MA Inhibitor DMVXKLF RN Prenylated pterocarpans as bacterial neuraminidase inhibitors. Bioorg Med Chem. 2010 May 1;18(9):3335-44. DMVXKLF RU https://pubmed.ncbi.nlm.nih.gov/20363636 DMR0CNQ DI DMR0CNQ DMR0CNQ DN Calpastatin DMR0CNQ MI TTG5QB7 DMR0CNQ MN Calpain-2 (CAPN2) DMR0CNQ MT DTT DMR0CNQ MA Inhibitor DMR0CNQ RN Calpain in the pathophysiology of spinal cord injury: neuroprotection with calpain inhibitors. Brain Res Brain Res Rev. 2003 May;42(2):169-85. DMR0CNQ RU https://pubmed.ncbi.nlm.nih.gov/12738057 DMBK2S8 DI DMBK2S8 DMBK2S8 DN Calusterone DMBK2S8 MI TTS64P2 DMBK2S8 MN Androgen receptor (AR) DMBK2S8 MT DTT DMBK2S8 MA Inhibitor DMBK2S8 RN MR appearance of intra-abdominal metastatic melanoma. Magn Reson Imaging. 1992;10(4):705-8. DMBK2S8 RU https://pubmed.ncbi.nlm.nih.gov/1501542 DMY29Q8 DI DMY29Q8 DMY29Q8 DN Calyculin-A DMY29Q8 MI TTS087L DMY29Q8 MN Solute carrier family 12 member 1 (SLC12A1) DMY29Q8 MT DTT DMY29Q8 MA Blocker DMY29Q8 RN Involvement of K(+)-Cl(-)-cotransport in the apoptosis induced by N-ethylmaleimide in HepG2 human hepatoblastoma cells. Eur J Pharmacol. 2001 Apr 20;418(1-2):1-5. DMY29Q8 RU https://pubmed.ncbi.nlm.nih.gov/11334858 DMMBA70 DI DMMBA70 DMMBA70 DN CALYSTEGINE B2 DMMBA70 MI TTIS03D DMMBA70 MN Alpha-galactosidase A (GLA) DMMBA70 MT DTT DMMBA70 MA Inhibitor DMMBA70 RN Identification of the glycosidase inhibitors swainsonine and calystegine B2 in Weir vine (Ipomoea sp. Q6 [aff. calobra]) and correlation with toxicity. J Nat Prod. 1995 Jun;58(6):878-86. DMMBA70 RU https://pubmed.ncbi.nlm.nih.gov/7673932 DM4FVDS DI DM4FVDS DM4FVDS DN CAM-2036 DM4FVDS MI TTVIMDE DM4FVDS MN Glucagon-like peptide 1 receptor (GLP1R) DM4FVDS MT DTT DM4FVDS MA Agonist DM4FVDS RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 249). DM4FVDS RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=249 DMVAP4T DI DMVAP4T DMVAP4T DN Camrelizumab DMVAP4T MI TTVLU5N DMVAP4T MN HUMAN programmed cell death protein 1 (PD-1) DMVAP4T MT DTT DMVAP4T MA Inhibitor DMVAP4T RN ClinicalTrials.gov (NCT04268537) Immunoregulatory Therapy for 2019-nCoV. U.S. National Institutes of Health. DMVAP4T RU https://clinicaltrials.gov/ct2/show/NCT04268537 DMNLTGF DI DMNLTGF DMNLTGF DN Canaline DMNLTGF MI TTTSCQ2 DMNLTGF MN Ornithine delta-aminotransferase (OAT) DMNLTGF MT DTT DMNLTGF MA Inhibitor DMNLTGF RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMNLTGF RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMM6A7P DI DMM6A7P DMM6A7P DN cannabinol DMM6A7P MI TT6OEDT DMM6A7P MN Cannabinoid receptor 1 (CB1) DMM6A7P MT DTT DMM6A7P MA Agonist DMM6A7P RN Evaluation of binding in a transfected cell line expressing a peripheral cannabinoid receptor (CB2): identification of cannabinoid receptor subtype selective ligands. J Pharmacol Exp Ther. 1996 Sep;278(3):989-99. DMM6A7P RU https://pubmed.ncbi.nlm.nih.gov/8819477 DMM6A7P DI DMM6A7P DMM6A7P DN cannabinol DMM6A7P MI TTBECWA DMM6A7P MN Transient receptor potential cation channel V2 (TRPV2) DMM6A7P MT DTT DMM6A7P MA Activator DMM6A7P RN TRPV2 is activated by cannabidiol and mediates CGRP release in cultured rat dorsal root ganglion neurons. J Neurosci. 2008 Jun 11;28(24):6231-8. DMM6A7P RU https://pubmed.ncbi.nlm.nih.gov/18550765 DME32XU DI DME32XU DME32XU DN CANTHARIDIC_ACID DME32XU MI TTFLH0E DME32XU MN Serine/threonine PP1-alpha (PPP1CA) DME32XU MT DTT DME32XU MA Inhibitor DME32XU RN Serine-threonine protein phosphatase inhibitors: development of potential therapeutic strategies. J Med Chem. 2002 Mar 14;45(6):1151-75. DME32XU RU https://pubmed.ncbi.nlm.nih.gov/11881984 DM9IG2P DI DM9IG2P DM9IG2P DN Cantide + Cisplatin DM9IG2P MI TTQY2EJ DM9IG2P MN TERT messenger RNA (TERT mRNA) DM9IG2P MT DTT DM9IG2P RN Design and development of antisense drugs. Expert Opin. Drug Discov. 2008 3(10):1189-1207. DM9IG2P RU http://www.informahealthcare.com/doi/abs/10.1517/17460441.3.10.1177 DMDZE8N DI DMDZE8N DMDZE8N DN CAPROCTAMINE DMDZE8N MI TT1RS9F DMDZE8N MN Acetylcholinesterase (AChE) DMDZE8N MT DTT DMDZE8N MA Inhibitor DMDZE8N RN Structure-activity relationships of acetylcholinesterase noncovalent inhibitors based on a polyamine backbone. 4. Further investigation on the inne... J Med Chem. 2008 Nov 27;51(22):7308-12. DMDZE8N RU https://pubmed.ncbi.nlm.nih.gov/18954037 DMDZE8N DI DMDZE8N DMDZE8N DN CAPROCTAMINE DMDZE8N MI TTEB0GD DMDZE8N MN Cholinesterase (BCHE) DMDZE8N MT DTT DMDZE8N MA Inhibitor DMDZE8N RN Structure-activity relationships of acetylcholinesterase noncovalent inhibitors based on a polyamine backbone. 4. Further investigation on the inne... J Med Chem. 2008 Nov 27;51(22):7308-12. DMDZE8N RU https://pubmed.ncbi.nlm.nih.gov/18954037 DMLGS82 DI DMLGS82 DMLGS82 DN Caprylic acid DMLGS82 MI TTPH97Y DMLGS82 MN Mycobacterium 3-oxoacyl-[acyl-carrier-protein] synthase 1 (MycB kasA) DMLGS82 MT DTT DMLGS82 MA Inhibitor DMLGS82 RN Characterization of ochratoxin A transport by human organic anion transporters. Life Sci. 2001 Sep 21;69(18):2123-35. DMLGS82 RU https://pubmed.ncbi.nlm.nih.gov/11669456 DM4ATCI DI DM4ATCI DM4ATCI DN CAPSAZEPINE DM4ATCI MI TTMI6F5 DM4ATCI MN Transient receptor potential cation channel V1 (TRPV1) DM4ATCI MT DTT DM4ATCI MA Inhibitor DM4ATCI RN The potential of transient receptor potential vanilloid type 1 channel modulators for the treatment of pain. J Med Chem. 2007 May 31;50(11):2589-96. DM4ATCI RU https://pubmed.ncbi.nlm.nih.gov/17489570 DM4ATCI DI DM4ATCI DM4ATCI DN CAPSAZEPINE DM4ATCI MI TTKP2SU DM4ATCI MN Transient receptor potential cation channel V4 (TRPV4) DM4ATCI MT DTT DM4ATCI MA Inhibitor DM4ATCI RN Chain-branched acyclic phenethylthiocarbamates as vanilloid receptor antagonists. Bioorg Med Chem Lett. 2003 May 5;13(9):1549-52. DM4ATCI RU https://pubmed.ncbi.nlm.nih.gov/12699752 DMJFPA9 DI DMJFPA9 DMJFPA9 DN CARAMIPEN DMJFPA9 MI TTZ9SOR DMJFPA9 MN Muscarinic acetylcholine receptor M1 (CHRM1) DMJFPA9 MT DTT DMJFPA9 MA Inhibitor DMJFPA9 RN Muscarinic receptor binding profile of para-substituted caramiphen analogues. J Med Chem. 1991 Oct;34(10):2984-9. DMJFPA9 RU https://pubmed.ncbi.nlm.nih.gov/1920350 DMJFPA9 DI DMJFPA9 DMJFPA9 DN CARAMIPEN DMJFPA9 MI TTYEG6Q DMJFPA9 MN Muscarinic acetylcholine receptor M2 (CHRM2) DMJFPA9 MT DTT DMJFPA9 MA Inhibitor DMJFPA9 RN Muscarinic receptor binding profile of para-substituted caramiphen analogues. J Med Chem. 1991 Oct;34(10):2984-9. DMJFPA9 RU https://pubmed.ncbi.nlm.nih.gov/1920350 DMEKI1J DI DMEKI1J DMEKI1J DN Carazolol DMEKI1J MI TTR6W5O DMEKI1J MN Adrenergic receptor beta-1 (ADRB1) DMEKI1J MT DTT DMEKI1J MA Agonist DMEKI1J RN Current therapeutic uses and potential of beta-adrenoceptor agonists and antagonists. Eur J Clin Pharmacol. 1998 Feb;53(6):389-404. DMEKI1J RU https://pubmed.ncbi.nlm.nih.gov/9551698 DMEKI1J DI DMEKI1J DMEKI1J DN Carazolol DMEKI1J MI TTMXGCW DMEKI1J MN Adrenergic receptor beta-3 (ADRB3) DMEKI1J MT DTT DMEKI1J MA Agonist DMEKI1J RN Current therapeutic uses and potential of beta-adrenoceptor agonists and antagonists. Eur J Clin Pharmacol. 1998 Feb;53(6):389-404. DMEKI1J RU https://pubmed.ncbi.nlm.nih.gov/9551698 DMMBQYE DI DMMBQYE DMMBQYE DN carbacyclin DMMBQYE MI TTOFYT1 DMMBQYE MN Prostacyclin receptor (PTGIR) DMMBQYE MT DTT DMMBQYE MA Agonist DMMBQYE RN The utilization of recombinant prostanoid receptors to determine the affinities and selectivities of prostaglandins and related analogs. Biochim Biophys Acta. 2000 Jan 17;1483(2):285-93. DMMBQYE RU https://pubmed.ncbi.nlm.nih.gov/10634944 DMMBQYE DI DMMBQYE DMMBQYE DN carbacyclin DMMBQYE MI TTNVEIR DMMBQYE MN Prostaglandin D2 receptor (PTGDR) DMMBQYE MT DTT DMMBQYE MA Agonist DMMBQYE RN The utilization of recombinant prostanoid receptors to determine the affinities and selectivities of prostaglandins and related analogs. Biochim Biophys Acta. 2000 Jan 17;1483(2):285-93. DMMBQYE RU https://pubmed.ncbi.nlm.nih.gov/10634944 DMMBQYE DI DMMBQYE DMMBQYE DN carbacyclin DMMBQYE MI TTG1QMU DMMBQYE MN Prostaglandin E2 receptor EP1 (PTGER1) DMMBQYE MT DTT DMMBQYE MA Agonist DMMBQYE RN The utilization of recombinant prostanoid receptors to determine the affinities and selectivities of prostaglandins and related analogs. Biochim Biophys Acta. 2000 Jan 17;1483(2):285-93. DMMBQYE RU https://pubmed.ncbi.nlm.nih.gov/10634944 DMMBQYE DI DMMBQYE DMMBQYE DN carbacyclin DMMBQYE MI TT1ZAVI DMMBQYE MN Prostaglandin E2 receptor EP2 (PTGER2) DMMBQYE MT DTT DMMBQYE MA Agonist DMMBQYE RN The utilization of recombinant prostanoid receptors to determine the affinities and selectivities of prostaglandins and related analogs. Biochim Biophys Acta. 2000 Jan 17;1483(2):285-93. DMMBQYE RU https://pubmed.ncbi.nlm.nih.gov/10634944 DMMBQYE DI DMMBQYE DMMBQYE DN carbacyclin DMMBQYE MI TTPNGDE DMMBQYE MN Prostaglandin E2 receptor EP3 (PTGER3) DMMBQYE MT DTT DMMBQYE MA Agonist DMMBQYE RN Ligand binding specificities of the eight types and subtypes of the mouse prostanoid receptors expressed in Chinese hamster ovary cells. Br J Pharmacol. 1997 Sep;122(2):217-24. DMMBQYE RU https://pubmed.ncbi.nlm.nih.gov/9313928 DMMBQYE DI DMMBQYE DMMBQYE DN carbacyclin DMMBQYE MI TT79WV3 DMMBQYE MN Prostaglandin E2 receptor EP4 (PTGER4) DMMBQYE MT DTT DMMBQYE MA Agonist DMMBQYE RN Ligand binding specificities of the eight types and subtypes of the mouse prostanoid receptors expressed in Chinese hamster ovary cells. Br J Pharmacol. 1997 Sep;122(2):217-24. DMMBQYE RU https://pubmed.ncbi.nlm.nih.gov/9313928 DMMBQYE DI DMMBQYE DMMBQYE DN carbacyclin DMMBQYE MI TTT2ZAR DMMBQYE MN Prostaglandin F2-alpha receptor (PTGFR) DMMBQYE MT DTT DMMBQYE MA Agonist DMMBQYE RN The utilization of recombinant prostanoid receptors to determine the affinities and selectivities of prostaglandins and related analogs. Biochim Biophys Acta. 2000 Jan 17;1483(2):285-93. DMMBQYE RU https://pubmed.ncbi.nlm.nih.gov/10634944 DMMBQYE DI DMMBQYE DMMBQYE DN carbacyclin DMMBQYE MI TT2O84V DMMBQYE MN Thromboxane A2 receptor (TBXA2R) DMMBQYE MT DTT DMMBQYE MA Agonist DMMBQYE RN The utilization of recombinant prostanoid receptors to determine the affinities and selectivities of prostaglandins and related analogs. Biochim Biophys Acta. 2000 Jan 17;1483(2):285-93. DMMBQYE RU https://pubmed.ncbi.nlm.nih.gov/10634944 DMJQ3LN DI DMJQ3LN DMJQ3LN DN Carbamic Acid DMJQ3LN MI TTHI19T DMJQ3LN MN Staphylococcus Beta-lactamase (Stap-coc blaZ) DMJQ3LN MT DTT DMJQ3LN MA Inhibitor DMJQ3LN RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMJQ3LN RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMZYK1W DI DMZYK1W DMZYK1W DN Carbamoyl phosphate disodium DMZYK1W MI TTHQPL7 DMZYK1W MN Carbonic anhydrase I (CA-I) DMZYK1W MT DTT DMZYK1W MA Inhibitor DMZYK1W RN Carbonic anhydrase inhibitors. Interaction of isozymes I, II, IV, V, and IX with phosphates, carbamoyl phosphate, and the phosphonate antiviral dru... Bioorg Med Chem Lett. 2004 Dec 6;14(23):5763-7. DMZYK1W RU https://pubmed.ncbi.nlm.nih.gov/15501037 DMZYK1W DI DMZYK1W DMZYK1W DN Carbamoyl phosphate disodium DMZYK1W MI TTZHA0O DMZYK1W MN Carbonic anhydrase IV (CA-IV) DMZYK1W MT DTT DMZYK1W MA Inhibitor DMZYK1W RN Carbonic anhydrase inhibitors. Interaction of isozymes I, II, IV, V, and IX with phosphates, carbamoyl phosphate, and the phosphonate antiviral dru... Bioorg Med Chem Lett. 2004 Dec 6;14(23):5763-7. DMZYK1W RU https://pubmed.ncbi.nlm.nih.gov/15501037 DMGP4M3 DI DMGP4M3 DMGP4M3 DN Carba-Nicotinamide-Adenine-Dinucleotide DMGP4M3 MI TTVDSZ0 DMGP4M3 MN Poly [ADP-ribose] polymerase 1 (PARP1) DMGP4M3 MT DTT DMGP4M3 MA Inhibitor DMGP4M3 RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMGP4M3 RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMGFLI7 DI DMGFLI7 DMGFLI7 DN Carbaphosphonate DMGFLI7 MI TTPS7KA DMGFLI7 MN Bacterial Dehydroquinate synthase (Bact aroB) DMGFLI7 MT DTT DMGFLI7 MA Inhibitor DMGFLI7 RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMGFLI7 RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMO648T DI DMO648T DMO648T DN Carbenoxolone DMO648T MI TTN7BL9 DMO648T MN Corticosteroid 11-beta-dehydrogenase 1 (HSD11B1) DMO648T MT DTT DMO648T MA Inhibitor DMO648T RN Selective inhibition of 11beta-hydroxysteroid dehydrogenase 1 by 18alpha-glycyrrhetinic acid but not 18beta-glycyrrhetinic acid. J Steroid Biochem Mol Biol. 2009 Feb;113(3-5):248-52. DMO648T RU https://pubmed.ncbi.nlm.nih.gov/19429429 DM87SOX DI DM87SOX DM87SOX DN Carbocyclic Peptidomimetic DM87SOX MI TT8JRS7 DM87SOX MN Beta-secretase (BACE) DM87SOX MT DTT DM87SOX MA Inhibitor DM87SOX RN Structure-based design, synthesis, and memapsin 2 (BACE) inhibitory activity of carbocyclic and heterocyclic peptidomimetics. J Med Chem. 2005 Aug 11;48(16):5175-90. DM87SOX RU https://pubmed.ncbi.nlm.nih.gov/16078837 DM87SOX DI DM87SOX DM87SOX DN Carbocyclic Peptidomimetic DM87SOX MI TTPT2QI DM87SOX MN Cathepsin D (CTSD) DM87SOX MT DTT DM87SOX MA Inhibitor DM87SOX RN Structure-based design, synthesis, and memapsin 2 (BACE) inhibitory activity of carbocyclic and heterocyclic peptidomimetics. J Med Chem. 2005 Aug 11;48(16):5175-90. DM87SOX RU https://pubmed.ncbi.nlm.nih.gov/16078837 DMGKSVF DI DMGKSVF DMGKSVF DN carbocyclic thromboxane A2 DMGKSVF MI TT2O84V DMGKSVF MN Thromboxane A2 receptor (TBXA2R) DMGKSVF MT DTT DMGKSVF MA Agonist DMGKSVF RN Effects of KW-3635, a novel dibenzoxepin derivative of a selective thromboxane A2 antagonist, on human, guinea pig and rat platelets. Jpn J Pharmacol. 1992 Jul;59(3):357-64. DMGKSVF RU https://pubmed.ncbi.nlm.nih.gov/1434130 DMA3FZR DI DMA3FZR DMA3FZR DN Carbodine DMA3FZR MI TTN12BZ DMA3FZR MN CTP synthase (CTPS1) DMA3FZR MT DTT DMA3FZR MA Inhibitor DMA3FZR RN Potent activity of 5-fluoro-2'-deoxyuridine and related compounds against thymidine kinase-deficient (TK-) herpes simplex virus: targeted at thymidylate synthase. Mol Pharmacol. 1987 Aug;32(1):286-92. DMA3FZR RU https://pubmed.ncbi.nlm.nih.gov/3039343 DMCNV68 DI DMCNV68 DMCNV68 DN Carboron Cluster with phenol DMCNV68 MI TTZAYWL DMCNV68 MN Estrogen receptor (ESR) DMCNV68 MT DTT DMCNV68 MA Inhibitor DMCNV68 RN Utility of boron clusters for drug design. Relation between estrogen receptor binding affinity and hydrophobicity of phenols bearing various types ... Bioorg Med Chem Lett. 2003 Nov 17;13(22):4089-92. DMCNV68 RU https://pubmed.ncbi.nlm.nih.gov/14592514 DMEORTQ DI DMEORTQ DMEORTQ DN Carboxyatractyloside DMEORTQ MI TTU5A6Q DMEORTQ MN Adenine nucleotide translocator 1 (SLC25A4) DMEORTQ MT DTT DMEORTQ MA Inhibitor DMEORTQ RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMEORTQ RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMTAYMR DI DMTAYMR DMTAYMR DN Carboxydichlorofluorescein DMTAYMR MI DTYVM24 DMTAYMR MN Multidrug resistance-associated protein 5 (ABCC5) DMTAYMR MT DTP DMTAYMR MA Substrate DMTAYMR RN Kinetic validation of the use of carboxydichlorofluorescein as a drug surrogate for MRP5-mediated transport. Eur J Pharm Sci. 2006 Apr;27(5):524-32. DMTAYMR RU http://www.ncbi.nlm.nih.gov/pubmed/16337112 DMI7Q61 DI DMI7Q61 DMI7Q61 DN CARBOXYFENTANYL DMI7Q61 MI TT27RFC DMI7Q61 MN Opioid receptor delta (OPRD1) DMI7Q61 MT DTT DMI7Q61 MA Inhibitor DMI7Q61 RN Development of novel enkephalin analogues that have enhanced opioid activities at both mu and delta opioid receptors. J Med Chem. 2007 Nov 1;50(22):5528-32. DMI7Q61 RU https://pubmed.ncbi.nlm.nih.gov/17927164 DMI7Q61 DI DMI7Q61 DMI7Q61 DN CARBOXYFENTANYL DMI7Q61 MI TTKWM86 DMI7Q61 MN Opioid receptor mu (MOP) DMI7Q61 MT DTT DMI7Q61 MA Inhibitor DMI7Q61 RN Development of novel enkephalin analogues that have enhanced opioid activities at both mu and delta opioid receptors. J Med Chem. 2007 Nov 1;50(22):5528-32. DMI7Q61 RU https://pubmed.ncbi.nlm.nih.gov/17927164 DM105YR DI DM105YR DM105YR DN Carboxylated glucosamine DM105YR MI TT6X50U DM105YR MN Matrix metalloproteinase-9 (MMP-9) DM105YR MT DTT DM105YR MA Inhibitor DM105YR RN Carboxy derivatized glucosamine is a potent inhibitor of matrix metalloproteinase-9 in HT1080 cells. Bioorg Med Chem Lett. 2006 Jun 15;16(12):3105-10. DM105YR RU https://pubmed.ncbi.nlm.nih.gov/16616490 DMCTUR1 DI DMCTUR1 DMCTUR1 DN Carboxylic PRPP DMCTUR1 MI TTBL49X DMCTUR1 MN Plasmodium Hypoxanthine-guanine phosphoribosyltransferase (Malaria LACZ) DMCTUR1 MT DTT DMCTUR1 MA Inhibitor DMCTUR1 RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMCTUR1 RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMQUKBG DI DMQUKBG DMQUKBG DN CARCININE DMQUKBG MI TT9JNIC DMQUKBG MN Histamine H3 receptor (H3R) DMQUKBG MT DTT DMQUKBG MA Inhibitor DMQUKBG RN The alkaloid conessine and analogues as potent histamine H3 receptor antagonists. J Med Chem. 2008 Sep 11;51(17):5423-30. DMQUKBG RU https://pubmed.ncbi.nlm.nih.gov/18683917 DMCSMX4 DI DMCSMX4 DMCSMX4 DN Cardiolipin DMCSMX4 MI TTU5A6Q DMCSMX4 MN Adenine nucleotide translocator 1 (SLC25A4) DMCSMX4 MT DTT DMCSMX4 MA Inhibitor DMCSMX4 RN DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Nucleic Acids Res. 2011 Jan;39(Database issue):D1035-41. DMCSMX4 RU https://pubmed.ncbi.nlm.nih.gov/21059682 DMUSGYQ DI DMUSGYQ DMUSGYQ DN Carinatumins B (2) DMUSGYQ MI TT1RS9F DMUSGYQ MN Acetylcholinesterase (AChE) DMUSGYQ MT DTT DMUSGYQ MA Inhibitor DMUSGYQ RN Carinatumins A-C, new alkaloids from Lycopodium carinatum inhibiting acetylcholinesterase. Bioorg Med Chem. 2007 Feb 15;15(4):1703-7. DMUSGYQ RU https://pubmed.ncbi.nlm.nih.gov/17188496 DMFYCB4 DI DMFYCB4 DMFYCB4 DN Carnosine DMFYCB4 MI DECY3P8 DMFYCB4 MN Carnosine N-methyltransferase (CARNMT1) DMFYCB4 MT DME DMFYCB4 MA Metabolism DMFYCB4 RN UPF0586 protein C9orf41 homolog is anserine-producing methyltransferase. J Biol Chem. 2015 Jul 10;290(28):17190-205. DMFYCB4 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=26001783 DMFYCB4 DI DMFYCB4 DMFYCB4 DN Carnosine DMFYCB4 MI DT9G7XN DMFYCB4 MN Peptide transporter 1 (SLC15A1) DMFYCB4 MT DTP DMFYCB4 MA Substrate DMFYCB4 RN Transforming dietary peptides in promising lead compounds: the case of bioavailable carnosine analogs. Amino Acids. 2012 Jul;43(1):111-26. DMFYCB4 RU https://doi.org/10.1007/s00726-012-1224-z DMBKQ03 DI DMBKQ03 DMBKQ03 DN Carpropamid DMBKQ03 MI TT64EPS DMBKQ03 MN Fungal Scytalone dehydratase (Fung SDH1) DMBKQ03 MT DTT DMBKQ03 MA Inhibitor DMBKQ03 RN Enzymatic characterization of scytalone dehydratase Val75Met variant found in melanin biosynthesis dehydratase inhibitor (MBI-D) resistant strains of the rice blast fungus. Biosci Biotechnol Biochem.2004 Mar;68(3):615-21. DMBKQ03 RU https://pubmed.ncbi.nlm.nih.gov/15056895 DMSKT8G DI DMSKT8G DMSKT8G DN Cartazolate DMSKT8G MI TTJ0IQB DMSKT8G MN Phosphodiesterase 5A (PDE5A) DMSKT8G MT DTT DMSKT8G MA Inhibitor DMSKT8G RN Substituted pyrazolopyridines as potent and selective PDE5 inhibitors: potential agents for treatment of erectile dysfunction. J Med Chem. 2001 Mar 29;44(7):1025-7. DMSKT8G RU https://pubmed.ncbi.nlm.nih.gov/11297448 DMINM2D DI DMINM2D DMINM2D DN carvacrol DMINM2D MI TTFPVZO DMINM2D MN Long transient receptor potential channel 7 (TRPM7) DMINM2D MT DTT DMINM2D MA Blocker (channel blocker) DMINM2D RN Carvacrol is a novel inhibitor of Drosophila TRPL and mammalian TRPM7 channels. Cell Calcium. 2009 Mar;45(3):300-9. DMINM2D RU https://pubmed.ncbi.nlm.nih.gov/19135721 DMINM2D DI DMINM2D DMINM2D DN carvacrol DMINM2D MI TT946IA DMINM2D MN Transient receptor potential cation channel V3 (TRPV3) DMINM2D MT DTT DMINM2D MA Activator DMINM2D RN Oregano, thyme and clove-derived flavors and skin sensitizers activate specific TRP channels. Nat Neurosci. 2006 May;9(5):628-35. DMINM2D RU https://pubmed.ncbi.nlm.nih.gov/16617338 DMXTCE7 DI DMXTCE7 DMXTCE7 DN Carvedilol DMXTCE7 MI TTDBOI7 DMXTCE7 MN HUAMN alpha-1 adrenergic receptor (ADRA1) DMXTCE7 MT DTT DMXTCE7 MA Inhibitor DMXTCE7 RN Carvedilol increases the production of interleukin-12 and interferon-gamma and improves the survival of mice infected with the encephalomyocarditis virus. J Am Coll Cardiol. 2003 Jan 15;41(2):340-5. DMXTCE7 RU https://pubmed.ncbi.nlm.nih.gov/12535832 DMXTCE7 DI DMXTCE7 DMXTCE7 DN Carvedilol DMXTCE7 MI TTJB8UY DMXTCE7 MN HUMAN beta adrenergic receptor (BAR) DMXTCE7 MT DTT DMXTCE7 MA Antagonist DMXTCE7 RN Can beta-adrenergic blockers be used in the treatment of COVID-19 Med Hypotheses. 2020 May 5;142:109809. DMXTCE7 RU https://pubmed.ncbi.nlm.nih.gov/32388480 DMGIZ5U DI DMGIZ5U DMGIZ5U DN carveol DMGIZ5U MI TT946IA DMGIZ5U MN Transient receptor potential cation channel V3 (TRPV3) DMGIZ5U MT DTT DMGIZ5U MA Activator DMGIZ5U RN Monoterpenoid agonists of TRPV3. Br J Pharmacol. 2007 Jun;151(4):530-40. DMGIZ5U RU https://pubmed.ncbi.nlm.nih.gov/17420775 DMVD481 DI DMVD481 DMVD481 DN Carzenide DMVD481 MI TTUNARX DMVD481 MN Carbonic anhydrase (CA) DMVD481 MT DTT DMVD481 MA Inhibitor DMVD481 RN Cloning, expression, post-translational modifications and inhibition studies on the latest mammalian carbonic anhydrase isoform, CA XV. J Med Chem. 2009 Feb 12;52(3):646-54. DMVD481 RU https://pubmed.ncbi.nlm.nih.gov/19193158 DMVD481 DI DMVD481 DMVD481 DN Carzenide DMVD481 MI TTHQPL7 DMVD481 MN Carbonic anhydrase I (CA-I) DMVD481 MT DTT DMVD481 MA Inhibitor DMVD481 RN Ligand-directed tosyl chemistry for protein labeling in vivo. Nat Chem Biol. 2009 May;5(5):341-3. DMVD481 RU https://pubmed.ncbi.nlm.nih.gov/19330012 DMVD481 DI DMVD481 DMVD481 DN Carzenide DMVD481 MI TTANPDJ DMVD481 MN Carbonic anhydrase II (CA-II) DMVD481 MT DTT DMVD481 MA Inhibitor DMVD481 RN Synthesis and structure-activity relationships of novel benzene sulfonamides with potent binding affinity for bovine carbonic anhydrase II. Bioorg Med Chem Lett. 2005 Dec 15;15(24):5429-33. DMVD481 RU https://pubmed.ncbi.nlm.nih.gov/16213706 DMVD481 DI DMVD481 DMVD481 DN Carzenide DMVD481 MI TT2LVK8 DMVD481 MN Carbonic anhydrase IX (CA-IX) DMVD481 MT DTT DMVD481 MA Inhibitor DMVD481 RN Cloning, expression, post-translational modifications and inhibition studies on the latest mammalian carbonic anhydrase isoform, CA XV. J Med Chem. 2009 Feb 12;52(3):646-54. DMVD481 RU https://pubmed.ncbi.nlm.nih.gov/19193158 DMVD481 DI DMVD481 DMVD481 DN Carzenide DMVD481 MI TTCFSPE DMVD481 MN Carbonic anhydrase VI (CA-VI) DMVD481 MT DTT DMVD481 MA Inhibitor DMVD481 RN Cloning, expression, post-translational modifications and inhibition studies on the latest mammalian carbonic anhydrase isoform, CA XV. J Med Chem. 2009 Feb 12;52(3):646-54. DMVD481 RU https://pubmed.ncbi.nlm.nih.gov/19193158 DMVD481 DI DMVD481 DMVD481 DN Carzenide DMVD481 MI TTSYM0R DMVD481 MN Carbonic anhydrase XII (CA-XII) DMVD481 MT DTT DMVD481 MA Inhibitor DMVD481 RN Carbonic anhydrase inhibitors. Inhibition of the transmembrane isozyme XII with sulfonamides-a new target for the design of antitumor and antiglauc... Bioorg Med Chem Lett. 2005 Feb 15;15(4):963-9. DMVD481 RU https://pubmed.ncbi.nlm.nih.gov/15686894 DMVD481 DI DMVD481 DMVD481 DN Carzenide DMVD481 MI TTEYTKG DMVD481 MN Carbonic anhydrase XIV (CA-XIV) DMVD481 MT DTT DMVD481 MA Inhibitor DMVD481 RN Carbonic anhydrase inhibitors: inhibition of the transmembrane isozyme XIV with sulfonamides. Bioorg Med Chem Lett. 2005 Sep 1;15(17):3828-33. DMVD481 RU https://pubmed.ncbi.nlm.nih.gov/16039848 DMW6P4A DI DMW6P4A DMW6P4A DN casp 4 inhib DMW6P4A MI TT3VZ8D DMW6P4A MN Caspase-4 (CASP4) DMW6P4A MT DTT DMW6P4A MA Inhibitor DMW6P4A RN Potent and selective nonpeptide inhibitors of caspases 3 and 7. J Med Chem. 2001 Jun 7;44(12):2015-26. DMW6P4A RU https://pubmed.ncbi.nlm.nih.gov/11384246 DM5E21C DI DM5E21C DM5E21C DN CASUARIIN DM5E21C MI TT6L509 DM5E21C MN Coagulation factor IIa (F2) DM5E21C MT DTT DM5E21C MA Inhibitor DM5E21C RN Effects of tannins from Geum japonicum on the catalytic activity of thrombin and factor Xa of blood coagulation cascade. J Nat Prod. 1998 Nov;61(11):1356-60. DM5E21C RU https://pubmed.ncbi.nlm.nih.gov/9834152 DM5E21C DI DM5E21C DM5E21C DN CASUARIIN DM5E21C MI TTCIHJA DM5E21C MN Coagulation factor Xa (F10) DM5E21C MT DTT DM5E21C MA Inhibitor DM5E21C RN Effects of tannins from Geum japonicum on the catalytic activity of thrombin and factor Xa of blood coagulation cascade. J Nat Prod. 1998 Nov;61(11):1356-60. DM5E21C RU https://pubmed.ncbi.nlm.nih.gov/9834152 DMWHP52 DI DMWHP52 DMWHP52 DN CAT-2200 DMWHP52 MI TT69OHW DMWHP52 MN Interleukin 17 receptor (IL17R) DMWHP52 MT DTT DMWHP52 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2294). DMWHP52 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2294 DMY38SB DI DMY38SB DMY38SB DN CATECHIN DMY38SB MI TTUNARX DMY38SB MN Carbonic anhydrase (CA) DMY38SB MT DTT DMY38SB MA Inhibitor DMY38SB RN Carbonic anhydrase inhibitors. Antioxidant polyphenols effectively inhibit mammalian isoforms I-XV. Bioorg Med Chem Lett. 2010 Sep 1;20(17):5050-3. DMY38SB RU https://pubmed.ncbi.nlm.nih.gov/20674354 DMY38SB DI DMY38SB DMY38SB DN CATECHIN DMY38SB MI TTHQPL7 DMY38SB MN Carbonic anhydrase I (CA-I) DMY38SB MT DTT DMY38SB MA Inhibitor DMY38SB RN Carbonic anhydrase inhibitors. Antioxidant polyphenols effectively inhibit mammalian isoforms I-XV. Bioorg Med Chem Lett. 2010 Sep 1;20(17):5050-3. DMY38SB RU https://pubmed.ncbi.nlm.nih.gov/20674354 DMY38SB DI DMY38SB DMY38SB DN CATECHIN DMY38SB MI TTANPDJ DMY38SB MN Carbonic anhydrase II (CA-II) DMY38SB MT DTT DMY38SB MA Inhibitor DMY38SB RN Carbonic anhydrase inhibitors. Antioxidant polyphenols effectively inhibit mammalian isoforms I-XV. Bioorg Med Chem Lett. 2010 Sep 1;20(17):5050-3. DMY38SB RU https://pubmed.ncbi.nlm.nih.gov/20674354 DMY38SB DI DMY38SB DMY38SB DN CATECHIN DMY38SB MI TTZHA0O DMY38SB MN Carbonic anhydrase IV (CA-IV) DMY38SB MT DTT DMY38SB MA Inhibitor DMY38SB RN Carbonic anhydrase inhibitors. Antioxidant polyphenols effectively inhibit mammalian isoforms I-XV. Bioorg Med Chem Lett. 2010 Sep 1;20(17):5050-3. DMY38SB RU https://pubmed.ncbi.nlm.nih.gov/20674354 DMY38SB DI DMY38SB DMY38SB DN CATECHIN DMY38SB MI TT2LVK8 DMY38SB MN Carbonic anhydrase IX (CA-IX) DMY38SB MT DTT DMY38SB MA Inhibitor DMY38SB RN Carbonic anhydrase inhibitors. Antioxidant polyphenols effectively inhibit mammalian isoforms I-XV. Bioorg Med Chem Lett. 2010 Sep 1;20(17):5050-3. DMY38SB RU https://pubmed.ncbi.nlm.nih.gov/20674354 DMY38SB DI DMY38SB DMY38SB DN CATECHIN DMY38SB MI TTCFSPE DMY38SB MN Carbonic anhydrase VI (CA-VI) DMY38SB MT DTT DMY38SB MA Inhibitor DMY38SB RN Carbonic anhydrase inhibitors. Antioxidant polyphenols effectively inhibit mammalian isoforms I-XV. Bioorg Med Chem Lett. 2010 Sep 1;20(17):5050-3. DMY38SB RU https://pubmed.ncbi.nlm.nih.gov/20674354 DMY38SB DI DMY38SB DMY38SB DN CATECHIN DMY38SB MI TTSYM0R DMY38SB MN Carbonic anhydrase XII (CA-XII) DMY38SB MT DTT DMY38SB MA Inhibitor DMY38SB RN Carbonic anhydrase inhibitors. Antioxidant polyphenols effectively inhibit mammalian isoforms I-XV. Bioorg Med Chem Lett. 2010 Sep 1;20(17):5050-3. DMY38SB RU https://pubmed.ncbi.nlm.nih.gov/20674354 DMY38SB DI DMY38SB DMY38SB DN CATECHIN DMY38SB MI TTEYTKG DMY38SB MN Carbonic anhydrase XIV (CA-XIV) DMY38SB MT DTT DMY38SB MA Inhibitor DMY38SB RN Carbonic anhydrase inhibitors. Antioxidant polyphenols effectively inhibit mammalian isoforms I-XV. Bioorg Med Chem Lett. 2010 Sep 1;20(17):5050-3. DMY38SB RU https://pubmed.ncbi.nlm.nih.gov/20674354 DMY38SB DI DMY38SB DMY38SB DN CATECHIN DMY38SB MI TT8NGED DMY38SB MN Prostaglandin G/H synthase 1 (COX-1) DMY38SB MT DTT DMY38SB MA Inhibitor DMY38SB RN Mechanism-based inactivation of COX-1 by red wine m-hydroquinones: a structure-activity relationship study. J Nat Prod. 2004 Nov;67(11):1777-82. DMY38SB RU https://pubmed.ncbi.nlm.nih.gov/15568761 DML0YEK DI DML0YEK DML0YEK DN Catechol DML0YEK MI TTUNARX DML0YEK MN Carbonic anhydrase (CA) DML0YEK MT DTT DML0YEK MA Inhibitor DML0YEK RN Carbonic anhydrase inhibitors. Inhibition of mammalian isoforms I-XIV with a series of natural product polyphenols and phenolic acids. Bioorg Med Chem. 2010 Mar 15;18(6):2159-2164. DML0YEK RU https://pubmed.ncbi.nlm.nih.gov/20185318 DML0YEK DI DML0YEK DML0YEK DN Catechol DML0YEK MI TTANPDJ DML0YEK MN Carbonic anhydrase II (CA-II) DML0YEK MT DTT DML0YEK MA Inhibitor DML0YEK RN Carbonic anhydrase inhibitors. Inhibition of mammalian isoforms I-XIV with a series of natural product polyphenols and phenolic acids. Bioorg Med Chem. 2010 Mar 15;18(6):2159-2164. DML0YEK RU https://pubmed.ncbi.nlm.nih.gov/20185318 DML0YEK DI DML0YEK DML0YEK DN Catechol DML0YEK MI TTZHA0O DML0YEK MN Carbonic anhydrase IV (CA-IV) DML0YEK MT DTT DML0YEK MA Inhibitor DML0YEK RN Carbonic anhydrase inhibitors. Inhibition of mammalian isoforms I-XIV with a series of natural product polyphenols and phenolic acids. Bioorg Med Chem. 2010 Mar 15;18(6):2159-2164. DML0YEK RU https://pubmed.ncbi.nlm.nih.gov/20185318 DML0YEK DI DML0YEK DML0YEK DN Catechol DML0YEK MI TTSYM0R DML0YEK MN Carbonic anhydrase XII (CA-XII) DML0YEK MT DTT DML0YEK MA Inhibitor DML0YEK RN Carbonic anhydrase inhibitors. Inhibition of mammalian isoforms I-XIV with a series of natural product polyphenols and phenolic acids. Bioorg Med Chem. 2010 Mar 15;18(6):2159-2164. DML0YEK RU https://pubmed.ncbi.nlm.nih.gov/20185318 DML0YEK DI DML0YEK DML0YEK DN Catechol DML0YEK MI DEWRN24 DML0YEK MN Glucansucrase (gtf106B) DML0YEK MT DME DML0YEK MA Metabolism DML0YEK RN Catechol glucosides act as donor/acceptor substrates of glucansucrase enzymes of Lactobacillus reuteri. Appl Microbiol Biotechnol. 2017 Jun;101(11):4495-4505. DML0YEK RU https://pubmed.ncbi.nlm.nih.gov/28258313 DMLEJHF DI DMLEJHF DMLEJHF DN Cation chloride DMLEJHF MI DT1MPHW DMLEJHF MN Electroneutral potassium-chloride cotransporter 4 (SLC12A7) DMLEJHF MT DTP DMLEJHF MA Substrate DMLEJHF RN A molecular analysis of the Na(+)-independent cation chloride cotransporters. Cell Physiol Biochem. 2013;32(7):14-31. DMLEJHF RU http://www.ncbi.nlm.nih.gov/pubmed/24429812 DMF7TBW DI DMF7TBW DMF7TBW DN CATPB DMF7TBW MI TT0FYAN DMF7TBW MN Free fatty acid receptor 2 (FFAR2) DMF7TBW MT DTT DMF7TBW MA Antagonist DMF7TBW RN Extracellular ionic locks determine variation in constitutive activity and ligand potency between species orthologs of the free fatty acid receptors FFA2 and FFA3. J Biol Chem. 2012 Nov 30;287(49):41195-209. DMF7TBW RU https://pubmed.ncbi.nlm.nih.gov/23066016 DM4QKVN DI DM4QKVN DM4QKVN DN CAULERPIN DM4QKVN MI TTELIN2 DM4QKVN MN PTPN1 messenger RNA (PTPN1 mRNA) DM4QKVN MT DTT DM4QKVN MA Inhibitor DM4QKVN RN Two novel aromatic valerenane-type sesquiterpenes from the Chinese green alga Caulerpa taxifolia. Bioorg Med Chem Lett. 2006 Jun 1;16(11):2947-50. DM4QKVN RU https://pubmed.ncbi.nlm.nih.gov/16563751 DM4O69H DI DM4O69H DM4O69H DN CAY 10471 DM4O69H MI TTQDMX5 DM4O69H MN Prostaglandin D2 receptor 2 (PTGDR2) DM4O69H MT DTT DM4O69H MA Agonist DM4O69H RN Minor structural modifications convert the dual TP/CRTH2 antagonist ramatroban into a highly selective and potent CRTH2 antagonist. J Med Chem. 2005 Feb 24;48(4):897-900. DM4O69H RU https://pubmed.ncbi.nlm.nih.gov/15715457 DMT3MBD DI DMT3MBD DMT3MBD DN CAY10583 DMT3MBD MI TTVJX54 DMT3MBD MN Leukotriene B4 receptor 2 (LTB4R2) DMT3MBD MT DTT DMT3MBD MA Agonist DMT3MBD RN Characterization of a mouse second leukotriene B4 receptor, mBLT2: BLT2-dependent ERK activation and cell migration of primary mouse keratinocytes. J Biol Chem. 2005 Jul 1;280(26):24816-23. DMT3MBD RU https://pubmed.ncbi.nlm.nih.gov/15866883 DMSFXZU DI DMSFXZU DMSFXZU DN CB-1922 DMSFXZU MI TT26PHO DMSFXZU MN Mineralocorticoid receptor (MR) DMSFXZU MT DTT DMSFXZU MA Inhibitor DMSFXZU RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 626). DMSFXZU RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=626 DMXON4L DI DMXON4L DMXON4L DN CB-676475 DMXON4L MI TTUTJGQ DMXON4L MN Vascular endothelial growth factor receptor 2 (KDR) DMXON4L MT DTT DMXON4L MA Inhibitor DMXON4L RN Synthesis of a novel biotin-tagged photoaffinity probe for VEGF receptor tyrosine kinases. Bioorg Med Chem Lett. 2006 Jan 1;16(1):129-33. DMXON4L RU https://pubmed.ncbi.nlm.nih.gov/16216503 DMXON4L DI DMXON4L DMXON4L DN CB-676475 DMXON4L MI TTDCBX5 DMXON4L MN Vascular endothelial growth factor receptor 3 (FLT-4) DMXON4L MT DTT DMXON4L MA Inhibitor DMXON4L RN Synthesis of a novel biotin-tagged photoaffinity probe for VEGF receptor tyrosine kinases. Bioorg Med Chem Lett. 2006 Jan 1;16(1):129-33. DMXON4L RU https://pubmed.ncbi.nlm.nih.gov/16216503 DMXON4L DI DMXON4L DMXON4L DN CB-676475 DMXON4L MI TT1VAUK DMXON4L MN VEGFR1 messenger RNA (VEGFR1 mRNA) DMXON4L MT DTT DMXON4L MA Inhibitor DMXON4L RN Synthesis and biological activity of N(4)-phenylsubstituted-6-(2,4-dichloro phenylmethyl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamines as vascular endo... Bioorg Med Chem. 2010 May 15;18(10):3575-87. DMXON4L RU https://pubmed.ncbi.nlm.nih.gov/20403700 DMALVY7 DI DMALVY7 DMALVY7 DN CBiPES DMALVY7 MI TTXJ47W DMALVY7 MN Metabotropic glutamate receptor 2 (mGluR2) DMALVY7 MT DTT DMALVY7 MA Modulator (allosteric modulator) DMALVY7 RN Metabotropic glutamate 2 receptor potentiators: receptor modulation, frequency-dependent synaptic activity, and efficacy in preclinical anxiety and... Psychopharmacology (Berl). 2005 Apr;179(1):271-83. DMALVY7 RU https://pubmed.ncbi.nlm.nih.gov/15717213 DMDIW1M DI DMDIW1M DMDIW1M DN CBIQ DMDIW1M MI TTRLZHP DMDIW1M MN cAMP-dependent chloride channel (CFTR) DMDIW1M MT DTT DMDIW1M MA Activator DMDIW1M RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 707). DMDIW1M RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=707 DMCFR8U DI DMCFR8U DMCFR8U DN CBLB-612 DMCFR8U MI TTY7ZHS DMCFR8U MN Toll-like receptor 2 (TLR2) DMCFR8U MT DTT DMCFR8U MA Modulator DMCFR8U RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1752). DMCFR8U RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1752 DMITY0H DI DMITY0H DMITY0H DN CBOBNEA DMITY0H MI TT0WAIE DMITY0H MN Melatonin receptor type 1A (MTNR1A) DMITY0H MT DTT DMITY0H MA Agonist DMITY0H RN Design, synthesis and pharmacological evaluation of novel naphthalenic derivatives as selective MT(1) melatoninergic ligands. Bioorg Med Chem. 2010 May 15;18(10):3426-36. DMITY0H RU https://pubmed.ncbi.nlm.nih.gov/20444610 DM21JVF DI DM21JVF DM21JVF DN Cbz-Glu(OtBu)-Ala-LeuVSMe DM21JVF MI TTUMQVO DM21JVF MN Cathepsin S (CTSS) DM21JVF MT DTT DM21JVF MA Inhibitor DM21JVF RN Optimization of subsite binding to the beta5 subunit of the human 20S proteasome using vinyl sulfones and 2-keto-1,3,4-oxadiazoles: syntheses and c... J Med Chem. 2006 May 18;49(10):2953-68. DM21JVF RU https://pubmed.ncbi.nlm.nih.gov/16686537 DMV8CJK DI DMV8CJK DMV8CJK DN Cbz-Ile-hPhe-Ala-LeuVSMe DMV8CJK MI TTUMQVO DMV8CJK MN Cathepsin S (CTSS) DMV8CJK MT DTT DMV8CJK MA Inhibitor DMV8CJK RN Optimization of subsite binding to the beta5 subunit of the human 20S proteasome using vinyl sulfones and 2-keto-1,3,4-oxadiazoles: syntheses and c... J Med Chem. 2006 May 18;49(10):2953-68. DMV8CJK RU https://pubmed.ncbi.nlm.nih.gov/16686537 DMBFLHD DI DMBFLHD DMBFLHD DN Cbz-Ile-Leu-Ala-LeuVSMe DMBFLHD MI TTF2LRI DMBFLHD MN Cathepsin B (CTSB) DMBFLHD MT DTT DMBFLHD MA Inhibitor DMBFLHD RN Optimization of subsite binding to the beta5 subunit of the human 20S proteasome using vinyl sulfones and 2-keto-1,3,4-oxadiazoles: syntheses and c... J Med Chem. 2006 May 18;49(10):2953-68. DMBFLHD RU https://pubmed.ncbi.nlm.nih.gov/16686537 DMBFLHD DI DMBFLHD DMBFLHD DN Cbz-Ile-Leu-Ala-LeuVSMe DMBFLHD MI TTUMQVO DMBFLHD MN Cathepsin S (CTSS) DMBFLHD MT DTT DMBFLHD MA Inhibitor DMBFLHD RN Optimization of subsite binding to the beta5 subunit of the human 20S proteasome using vinyl sulfones and 2-keto-1,3,4-oxadiazoles: syntheses and c... J Med Chem. 2006 May 18;49(10):2953-68. DMBFLHD RU https://pubmed.ncbi.nlm.nih.gov/16686537 DMI53WR DI DMI53WR DMI53WR DN Cbz-Ile-Leu-L-(difluoro)aminobutyric acid DMI53WR MI TTWXB3E DMI53WR MN Hepatitis C virus NS3 helicase (HCV NS3) DMI53WR MT DTT DMI53WR MA Inhibitor DMI53WR RN Control of hepatitis C: a medicinal chemistry perspective. J Med Chem. 2005 Jan 13;48(1):1-20. DMI53WR RU https://pubmed.ncbi.nlm.nih.gov/15633995 DMY4M3J DI DMY4M3J DMY4M3J DN Cbz-Ile-MetO2-Ala-LeuVSMe DMY4M3J MI TTUMQVO DMY4M3J MN Cathepsin S (CTSS) DMY4M3J MT DTT DMY4M3J MA Inhibitor DMY4M3J RN Optimization of subsite binding to the beta5 subunit of the human 20S proteasome using vinyl sulfones and 2-keto-1,3,4-oxadiazoles: syntheses and c... J Med Chem. 2006 May 18;49(10):2953-68. DMY4M3J RU https://pubmed.ncbi.nlm.nih.gov/16686537 DM1OAW3 DI DM1OAW3 DM1OAW3 DN Cbz-Ile-Phe-Ala-LeuVSMe DM1OAW3 MI TTUMQVO DM1OAW3 MN Cathepsin S (CTSS) DM1OAW3 MT DTT DM1OAW3 MA Inhibitor DM1OAW3 RN Optimization of subsite binding to the beta5 subunit of the human 20S proteasome using vinyl sulfones and 2-keto-1,3,4-oxadiazoles: syntheses and c... J Med Chem. 2006 May 18;49(10):2953-68. DM1OAW3 RU https://pubmed.ncbi.nlm.nih.gov/16686537 DM1KDWE DI DM1KDWE DM1KDWE DN Cbz-Ile-Pro-Ala-LeuVSMe DM1KDWE MI TTUMQVO DM1KDWE MN Cathepsin S (CTSS) DM1KDWE MT DTT DM1KDWE MA Inhibitor DM1KDWE RN Optimization of subsite binding to the beta5 subunit of the human 20S proteasome using vinyl sulfones and 2-keto-1,3,4-oxadiazoles: syntheses and c... J Med Chem. 2006 May 18;49(10):2953-68. DM1KDWE RU https://pubmed.ncbi.nlm.nih.gov/16686537 DMGTFON DI DMGTFON DMGTFON DN Cbz-Ile-t-ButylGln-Ala-LeuVSMe DMGTFON MI TTUMQVO DMGTFON MN Cathepsin S (CTSS) DMGTFON MT DTT DMGTFON MA Inhibitor DMGTFON RN Optimization of subsite binding to the beta5 subunit of the human 20S proteasome using vinyl sulfones and 2-keto-1,3,4-oxadiazoles: syntheses and c... J Med Chem. 2006 May 18;49(10):2953-68. DMGTFON RU https://pubmed.ncbi.nlm.nih.gov/16686537 DMNKC9J DI DMNKC9J DMNKC9J DN Cbz-Ile-t-ButylhomoGlu-Ala-LeuVSMe DMNKC9J MI TTF2LRI DMNKC9J MN Cathepsin B (CTSB) DMNKC9J MT DTT DMNKC9J MA Inhibitor DMNKC9J RN Optimization of subsite binding to the beta5 subunit of the human 20S proteasome using vinyl sulfones and 2-keto-1,3,4-oxadiazoles: syntheses and c... J Med Chem. 2006 May 18;49(10):2953-68. DMNKC9J RU https://pubmed.ncbi.nlm.nih.gov/16686537 DMNKC9J DI DMNKC9J DMNKC9J DN Cbz-Ile-t-ButylhomoGlu-Ala-LeuVSMe DMNKC9J MI TTUMQVO DMNKC9J MN Cathepsin S (CTSS) DMNKC9J MT DTT DMNKC9J MA Inhibitor DMNKC9J RN Optimization of subsite binding to the beta5 subunit of the human 20S proteasome using vinyl sulfones and 2-keto-1,3,4-oxadiazoles: syntheses and c... J Med Chem. 2006 May 18;49(10):2953-68. DMNKC9J RU https://pubmed.ncbi.nlm.nih.gov/16686537 DM6TYRA DI DM6TYRA DM6TYRA DN Cbz-Val-Pro-Val-(2-benzoxazole) DM6TYRA MI TTPLTSQ DM6TYRA MN Neutrophil elastase (NE) DM6TYRA MT DTT DM6TYRA MA Inhibitor DM6TYRA RN Inhibitors of proteases and amide hydrolases that employ an alpha-ketoheterocycle as a key enabling functionality. Bioorg Med Chem. 2008 Feb 15;16(4):1562-95. DM6TYRA RU https://pubmed.ncbi.nlm.nih.gov/18053726 DMSE20Y DI DMSE20Y DMSE20Y DN CCACSSKWCRDHSRCC DMSE20Y MI TT84DRB DMSE20Y MN Voltage-gated sodium channel alpha Nav1.4 (SCN4A) DMSE20Y MT DTT DMSE20Y MA Inhibitor DMSE20Y RN Structure/function characterization of micro-conotoxin KIIIA, an analgesic, nearly irreversible blocker of mammalian neuronal sodium channels. J Biol Chem. 2007 Oct 19;282(42):30699-706. DMSE20Y RU https://pubmed.ncbi.nlm.nih.gov/17724025 DMUQJ6X DI DMUQJ6X DMUQJ6X DN CCG-50014 DMUQJ6X MI TTGTKX9 DMUQJ6X MN Regulator of G-protein signaling 4 (RGS4) DMUQJ6X MT DTT DMUQJ6X MA Inhibitor DMUQJ6X RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2811). DMUQJ6X RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2811 DMUQJ6X DI DMUQJ6X DMUQJ6X DN CCG-50014 DMUQJ6X MI TTWME23 DMUQJ6X MN Regulator of G-protein signaling 8 (RGS8) DMUQJ6X MT DTT DMUQJ6X MA Inhibitor DMUQJ6X RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2813). DMUQJ6X RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2813 DM1N0ED DI DM1N0ED DM1N0ED DN CCK-33 DM1N0ED MI TTCG0AL DM1N0ED MN Cholecystokinin receptor type A (CCKAR) DM1N0ED MT DTT DM1N0ED MA Agonist DM1N0ED RN Distinct cholecystokinin receptors in brain and pancreas. Proc Natl Acad Sci U S A. 1980 Nov;77(11):6917-21. DM1N0ED RU https://pubmed.ncbi.nlm.nih.gov/6256771 DM1N0ED DI DM1N0ED DM1N0ED DN CCK-33 DM1N0ED MI TTVFO0U DM1N0ED MN Gastrin/cholecystokinin type B receptor (CCKBR) DM1N0ED MT DTT DM1N0ED MA Agonist DM1N0ED RN Functional characterization of a human brain cholecystokinin-B receptor. A trophic effect of cholecystokinin and gastrin. J Biol Chem. 1993 Aug 25;268(24):18300-5. DM1N0ED RU https://pubmed.ncbi.nlm.nih.gov/8349705 DMN0J4W DI DMN0J4W DMN0J4W DN CCK-8 DMN0J4W MI TTCG0AL DMN0J4W MN Cholecystokinin receptor type A (CCKAR) DMN0J4W MT DTT DMN0J4W MA Agonist DMN0J4W RN Development of a class of selective cholecystokinin type B receptor antagonists having potent anxiolytic activity. Proc Natl Acad Sci U S A. 1990 Sep;87(17):6728-32. DMN0J4W RU https://pubmed.ncbi.nlm.nih.gov/1975695 DMN0J4W DI DMN0J4W DMN0J4W DN CCK-8 DMN0J4W MI TTVFO0U DMN0J4W MN Gastrin/cholecystokinin type B receptor (CCKBR) DMN0J4W MT DTT DMN0J4W MA Agonist DMN0J4W RN Functional characterization of a human brain cholecystokinin-B receptor. A trophic effect of cholecystokinin and gastrin. J Biol Chem. 1993 Aug 25;268(24):18300-5. DMN0J4W RU https://pubmed.ncbi.nlm.nih.gov/8349705 DMN0J4W DI DMN0J4W DMN0J4W DN CCK-8 DMN0J4W MI DTFI42L DMN0J4W MN Multidrug resistance-associated protein 2 (ABCC2) DMN0J4W MT DTP DMN0J4W MA Substrate DMN0J4W RN Human hepatobiliary transport of organic anions analyzed by quadruple-transfected cells. Mol Pharmacol. 2005 Oct;68(4):1031-8. DMN0J4W RU http://www.ncbi.nlm.nih.gov/pubmed/16046661 DMN0J4W DI DMN0J4W DMN0J4W DN CCK-8 DMN0J4W MI DT3D8F0 DMN0J4W MN Organic anion transporting polypeptide 1B1 (SLCO1B1) DMN0J4W MT DTP DMN0J4W MA Substrate DMN0J4W RN Organic anion transporting polypeptide 1B1: a genetically polymorphic transporter of major importance for hepatic drug uptake. Pharmacol Rev. 2011 Mar;63(1):157-81. DMN0J4W RU http://www.ncbi.nlm.nih.gov/pubmed/21245207 DMN0J4W DI DMN0J4W DMN0J4W DN CCK-8 DMN0J4W MI DT9C1TS DMN0J4W MN Organic anion transporting polypeptide 1B3 (SLCO1B3) DMN0J4W MT DTP DMN0J4W MA Substrate DMN0J4W RN Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions. J Med Chem. 2012 May 24;55(10):4740-63. DMN0J4W RU http://www.ncbi.nlm.nih.gov/pubmed/22541068 DMRFA5O DI DMRFA5O DMRFA5O DN CCNCASKWCRDHSRCC DMRFA5O MI TT84DRB DMRFA5O MN Voltage-gated sodium channel alpha Nav1.4 (SCN4A) DMRFA5O MT DTT DMRFA5O MA Inhibitor DMRFA5O RN Structure/function characterization of micro-conotoxin KIIIA, an analgesic, nearly irreversible blocker of mammalian neuronal sodium channels. J Biol Chem. 2007 Oct 19;282(42):30699-706. DMRFA5O RU https://pubmed.ncbi.nlm.nih.gov/17724025 DMZKJ37 DI DMZKJ37 DMZKJ37 DN CCNCSAKWCRDHSRCC DMZKJ37 MI TT84DRB DMZKJ37 MN Voltage-gated sodium channel alpha Nav1.4 (SCN4A) DMZKJ37 MT DTT DMZKJ37 MA Inhibitor DMZKJ37 RN Structure/function characterization of micro-conotoxin KIIIA, an analgesic, nearly irreversible blocker of mammalian neuronal sodium channels. J Biol Chem. 2007 Oct 19;282(42):30699-706. DMZKJ37 RU https://pubmed.ncbi.nlm.nih.gov/17724025 DM96YR2 DI DM96YR2 DM96YR2 DN CCNCSSKWCRAHSRCC DM96YR2 MI TT84DRB DM96YR2 MN Voltage-gated sodium channel alpha Nav1.4 (SCN4A) DM96YR2 MT DTT DM96YR2 MA Inhibitor DM96YR2 RN Structure/function characterization of micro-conotoxin KIIIA, an analgesic, nearly irreversible blocker of mammalian neuronal sodium channels. J Biol Chem. 2007 Oct 19;282(42):30699-706. DM96YR2 RU https://pubmed.ncbi.nlm.nih.gov/17724025 DMP0C7B DI DMP0C7B DMP0C7B DN CCNCSSKWCRDHARCC DMP0C7B MI TT84DRB DMP0C7B MN Voltage-gated sodium channel alpha Nav1.4 (SCN4A) DMP0C7B MT DTT DMP0C7B MA Inhibitor DMP0C7B RN Structure/function characterization of micro-conotoxin KIIIA, an analgesic, nearly irreversible blocker of mammalian neuronal sodium channels. J Biol Chem. 2007 Oct 19;282(42):30699-706. DMP0C7B RU https://pubmed.ncbi.nlm.nih.gov/17724025 DMBGHTW DI DMBGHTW DMBGHTW DN CCNCSSKWCRDHSRCC DMBGHTW MI TTAXZ0K DMBGHTW MN Voltage-gated sodium channel alpha Nav1.3 (SCN3A) DMBGHTW MT DTT DMBGHTW MA Inhibitor DMBGHTW RN Structure/function characterization of micro-conotoxin KIIIA, an analgesic, nearly irreversible blocker of mammalian neuronal sodium channels. J Biol Chem. 2007 Oct 19;282(42):30699-706. DMBGHTW RU https://pubmed.ncbi.nlm.nih.gov/17724025 DMBGHTW DI DMBGHTW DMBGHTW DN CCNCSSKWCRDHSRCC DMBGHTW MI TT84DRB DMBGHTW MN Voltage-gated sodium channel alpha Nav1.4 (SCN4A) DMBGHTW MT DTT DMBGHTW MA Inhibitor DMBGHTW RN Structure/function characterization of micro-conotoxin KIIIA, an analgesic, nearly irreversible blocker of mammalian neuronal sodium channels. J Biol Chem. 2007 Oct 19;282(42):30699-706. DMBGHTW RU https://pubmed.ncbi.nlm.nih.gov/17724025 DM2UJM8 DI DM2UJM8 DM2UJM8 DN CCP DM2UJM8 MI TTMN4HY DM2UJM8 MN N-acylethanolamine-hydrolyzing acidamidase (NAAA) DM2UJM8 MT DTT DM2UJM8 MA Inhibitor DM2UJM8 RN N-cyclohexanecarbonylpentadecylamine: a selective inhibitor of the acid amidase hydrolysing N-acylethanolamines, as a tool to distinguish acid amidase from fatty acid amide hydrolase. Biochem J. 2004Apr 1;379(Pt 1):99-106. DM2UJM8 RU https://pubmed.ncbi.nlm.nih.gov/14686878 DMZXFT9 DI DMZXFT9 DMZXFT9 DN CCT-241533 DMZXFT9 MI TT9ABMF DMZXFT9 MN Serine/threonine-protein kinase Chk2 (RAD53) DMZXFT9 MT DTT DMZXFT9 MA Inhibitor DMZXFT9 RN CCT241533 Is a Potent and Selective Inhibitor of CHK2 that Potentiates the Cytotoxicity of PARP Inhibitors. Cancer Res. 2011 Jan 15;71(2):463-72. DMZXFT9 RU https://pubmed.ncbi.nlm.nih.gov/21239475 DMSDH3A DI DMSDH3A DMSDH3A DN CCT244747 DMSDH3A MI TTV6WMQ DMSDH3A MN BR serine/threonine kinase 1 (BRSK1) DMSDH3A MT DTT DMSDH3A MA Inhibitor DMSDH3A RN Discovery of 3-alkoxyamino-5-(pyridin-2-ylamino)pyrazine-2-carbonitriles as selective, orally bioavailable CHK1 inhibitors. J Med Chem. 2012 Nov 26;55(22):10229-40. DMSDH3A RU https://pubmed.ncbi.nlm.nih.gov/23082860 DMSDH3A DI DMSDH3A DMSDH3A DN CCT244747 DMSDH3A MI TTHZN4X DMSDH3A MN BR serine/threonine kinase 2 (BRSK2) DMSDH3A MT DTT DMSDH3A MA Inhibitor DMSDH3A RN Discovery of 3-alkoxyamino-5-(pyridin-2-ylamino)pyrazine-2-carbonitriles as selective, orally bioavailable CHK1 inhibitors. J Med Chem. 2012 Nov 26;55(22):10229-40. DMSDH3A RU https://pubmed.ncbi.nlm.nih.gov/23082860 DMSDH3A DI DMSDH3A DMSDH3A DN CCT244747 DMSDH3A MI TTTU902 DMSDH3A MN Checkpoint kinase-1 (CHK1) DMSDH3A MT DTT DMSDH3A MA Inhibitor DMSDH3A RN Discovery of 3-alkoxyamino-5-(pyridin-2-ylamino)pyrazine-2-carbonitriles as selective, orally bioavailable CHK1 inhibitors. J Med Chem. 2012 Nov 26;55(22):10229-40. DMSDH3A RU https://pubmed.ncbi.nlm.nih.gov/23082860 DM6WX1A DI DM6WX1A DM6WX1A DN CCX-662 DM6WX1A MI TTRQJTC DM6WX1A MN C-X-C chemokine receptor type 7 (ACKR3) DM6WX1A MT DTT DM6WX1A MA Antagonist DM6WX1A RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 80). DM6WX1A RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=80 DM9BMDO DI DM9BMDO DM9BMDO DN CD154 DM9BMDO MI TTN6Y9A DM9BMDO MN CD40L receptor (CD40) DM9BMDO MT DTT DM9BMDO MA Binder DM9BMDO RN Growth-inhibitory effects of CD40 ligand (CD154) and its endogenous expression in human breast cancer. Clin Cancer Res. 2001 Mar;7(3):691-703. DM9BMDO RU https://pubmed.ncbi.nlm.nih.gov/11297266 DMT6M5E DI DMT6M5E DMT6M5E DN CD-160130 DMT6M5E MI TTZ97H5 DMT6M5E MN Phosphodiesterase 4A (PDE4A) DMT6M5E MT DTT DMT6M5E MA Inhibitor DMT6M5E RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1300). DMT6M5E RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1300 DMT6M5E DI DMT6M5E DMT6M5E DN CD-160130 DMT6M5E MI TTVIAT9 DMT6M5E MN Phosphodiesterase 4B (PDE4B) DMT6M5E MT DTT DMT6M5E MA Inhibitor DMT6M5E RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1301). DMT6M5E RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1301 DMT6M5E DI DMT6M5E DMT6M5E DN CD-160130 DMT6M5E MI TTSKMI8 DMT6M5E MN Phosphodiesterase 4D (PDE4D) DMT6M5E MT DTT DMT6M5E MA Inhibitor DMT6M5E RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1303). DMT6M5E RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1303 DM05M9X DI DM05M9X DM05M9X DN CD2665 DM05M9X MI TT1Q3IE DM05M9X MN Retinoic acid receptor gamma (RARG) DM05M9X MT DTT DM05M9X MA Antagonist DM05M9X RN Induction of apoptosis by retinoids and retinoic acid receptor gamma-selective compounds in mouse thymocytes through a novel apoptosis pathway. Mol Pharmacol. 1997 Jun;51(6):972-82. DM05M9X RU https://pubmed.ncbi.nlm.nih.gov/9187263 DM38MU1 DI DM38MU1 DM38MU1 DN CD3254 DM38MU1 MI TT6PEUO DM38MU1 MN Retinoic acid receptor RXR-alpha (RXRA) DM38MU1 MT DTT DM38MU1 MA Agonist DM38MU1 RN Co-regulator recruitment and the mechanism of retinoic acid receptor synergy. Nature. 2002 Jan 10;415(6868):187-92. DM38MU1 RU https://pubmed.ncbi.nlm.nih.gov/11805839 DMIV82T DI DMIV82T DMIV82T DN CD4 red blood cell electroinsertion DMIV82T MI TTBYP1X DMIV82T MN Human immunodeficiency virus Envelope glycoprotein gp120 (HIV gp120) DMIV82T MT DTT DMIV82T MA Modulator DMIV82T RN Red blood cells bearing CD4 bind to gp120 covered plates and aggregate with cells expressing gp120. J Acquir Immune Defic Syndr. 1990;3(11):1041-5. DMIV82T RU https://www.ncbi.nlm.nih.gov/pubmed/1698964 DMFQVLW DI DMFQVLW DMFQVLW DN CD45RB DMFQVLW MI TTE4KHA DMFQVLW MN Amyloid beta A4 protein (APP) DMFQVLW MT DTT DMFQVLW MA Agonist DMFQVLW RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2402). DMFQVLW RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2402 DMZ2LPO DI DMZ2LPO DMZ2LPO DN CD564 DMZ2LPO MI TT1Q3IE DMZ2LPO MN Retinoic acid receptor gamma (RARG) DMZ2LPO MT DTT DMZ2LPO MA Inhibitor DMZ2LPO RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMZ2LPO RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMC8X9Y DI DMC8X9Y DMC8X9Y DN CD666 DMC8X9Y MI TTW38KT DMC8X9Y MN Retinoic acid receptor alpha (RARA) DMC8X9Y MT DTT DMC8X9Y MA Agonist DMC8X9Y RN Identification of synthetic retinoids with selectivity for human nuclear retinoic acid receptor gamma. Biochem Biophys Res Commun. 1992 Jul 31;186(2):977-83. DMC8X9Y RU https://pubmed.ncbi.nlm.nih.gov/1323296 DMC8X9Y DI DMC8X9Y DMC8X9Y DN CD666 DMC8X9Y MI TTISP28 DMC8X9Y MN Retinoic acid receptor beta (RARB) DMC8X9Y MT DTT DMC8X9Y MA Agonist DMC8X9Y RN Identification of synthetic retinoids with selectivity for human nuclear retinoic acid receptor gamma. Biochem Biophys Res Commun. 1992 Jul 31;186(2):977-83. DMC8X9Y RU https://pubmed.ncbi.nlm.nih.gov/1323296 DMC8X9Y DI DMC8X9Y DMC8X9Y DN CD666 DMC8X9Y MI TT1Q3IE DMC8X9Y MN Retinoic acid receptor gamma (RARG) DMC8X9Y MT DTT DMC8X9Y MA Agonist DMC8X9Y RN Identification of synthetic retinoids with selectivity for human nuclear retinoic acid receptor gamma. Biochem Biophys Res Commun. 1992 Jul 31;186(2):977-83. DMC8X9Y RU https://pubmed.ncbi.nlm.nih.gov/1323296 DMWP63C DI DMWP63C DMWP63C DN CD79-targeted immunotoxins DMWP63C MI TTBN5I7 DMWP63C MN B-cell-specific glycoprotein B29 (CD79B) DMWP63C MT DTT DMWP63C RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2852). DMWP63C RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2852 DMFYWE3 DI DMFYWE3 DMFYWE3 DN CD-832.HCL DMFYWE3 MI TT5HONZ DMFYWE3 MN Calcium channel unspecific (CaC) DMFYWE3 MT DTT DMFYWE3 MA Modulator DMFYWE3 RN Actions of a new Ca2+ channel antagonist, CD832, on two types of Ca2+ channels in smooth muscle. Eur J Pharmacol. 1994 Feb 11;252(3):267-74. DMFYWE3 RU https://www.ncbi.nlm.nih.gov/pubmed/8162949 DM03NUV DI DM03NUV DM03NUV DN CDDO DM03NUV MI TTF10I9 DM03NUV MN Nitric-oxide synthase inducible (NOS2) DM03NUV MT DTT DM03NUV MA Inhibitor DM03NUV RN Studies on the reactivity of CDDO, a promising new chemopreventive and chemotherapeutic agent: implications for a molecular mechanism of action. Bioorg Med Chem Lett. 2005 May 2;15(9):2215-9. DM03NUV RU https://pubmed.ncbi.nlm.nih.gov/15837296 DMNW12R DI DMNW12R DMNW12R DN Cdk1 inhibitor DMNW12R MI TTH6V3D DMNW12R MN Cyclin-dependent kinase 1 (CDK1) DMNW12R MT DTT DMNW12R MA Inhibitor DMNW12R RN A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases. Proc Natl Acad Sci U S A. 2007 Dec 18;104(51):20523-8. DMNW12R RU https://pubmed.ncbi.nlm.nih.gov/18077363 DMS62T0 DI DMS62T0 DMS62T0 DN Cdk1/2 inhibitor III DMS62T0 MI TTH6V3D DMS62T0 MN Cyclin-dependent kinase 1 (CDK1) DMS62T0 MT DTT DMS62T0 MA Inhibitor DMS62T0 RN 1-Acyl-1H-[1,2,4]triazole-3,5-diamine analogues as novel and potent anticancer cyclin-dependent kinase inhibitors: synthesis and evaluation of biological activities. J Med Chem. 2005 Jun 30;48(13):4208-11. DMS62T0 RU https://pubmed.ncbi.nlm.nih.gov/15974571 DMS62T0 DI DMS62T0 DMS62T0 DN Cdk1/2 inhibitor III DMS62T0 MI TT7HF4W DMS62T0 MN Cyclin-dependent kinase 2 (CDK2) DMS62T0 MT DTT DMS62T0 MA Inhibitor DMS62T0 RN 1-Acyl-1H-[1,2,4]triazole-3,5-diamine analogues as novel and potent anticancer cyclin-dependent kinase inhibitors: synthesis and evaluation of biological activities. J Med Chem. 2005 Jun 30;48(13):4208-11. DMS62T0 RU https://pubmed.ncbi.nlm.nih.gov/15974571 DMS62T0 DI DMS62T0 DMS62T0 DN Cdk1/2 inhibitor III DMS62T0 MI TT1VAUK DMS62T0 MN VEGFR1 messenger RNA (VEGFR1 mRNA) DMS62T0 MT DTT DMS62T0 MA Inhibitor DMS62T0 RN 1-Acyl-1H-[1,2,4]triazole-3,5-diamine analogues as novel and potent anticancer cyclin-dependent kinase inhibitors: synthesis and evaluation of biological activities. J Med Chem. 2005 Jun 30;48(13):4208-11. DMS62T0 RU https://pubmed.ncbi.nlm.nih.gov/15974571 DMNZJAX DI DMNZJAX DMNZJAX DN Cdk4 inhibitor III DMNZJAX MI TT7HF4W DMNZJAX MN Cyclin-dependent kinase 2 (CDK2) DMNZJAX MT DTT DMNZJAX MA Inhibitor DMNZJAX RN 5-Arylamino-2-methyl-4,7-dioxobenzothiazoles as inhibitors of cyclin-dependent kinase 4 and cytotoxic agents. Bioorg Med Chem Lett. 2000 Mar 6;10(5):461-4. DMNZJAX RU https://pubmed.ncbi.nlm.nih.gov/10743948 DMNZJAX DI DMNZJAX DMNZJAX DN Cdk4 inhibitor III DMNZJAX MI TT0PG8F DMNZJAX MN Cyclin-dependent kinase 4 (CDK4) DMNZJAX MT DTT DMNZJAX MA Inhibitor DMNZJAX RN 5-Arylamino-2-methyl-4,7-dioxobenzothiazoles as inhibitors of cyclin-dependent kinase 4 and cytotoxic agents. Bioorg Med Chem Lett. 2000 Mar 6;10(5):461-4. DMNZJAX RU https://pubmed.ncbi.nlm.nih.gov/10743948 DMQDA5W DI DMQDA5W DMQDA5W DN CDRI-85/92 DMQDA5W MI TTF1QVM DMQDA5W MN Gastric H(+)/K(+) ATPase alpha (ATP4A) DMQDA5W MT DTT DMQDA5W MA Inhibitor DMQDA5W RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 849). DMQDA5W RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=849 DMUKGEA DI DMUKGEA DMUKGEA DN Cebutolol DMUKGEA MI TTR6W5O DMUKGEA MN Adrenergic receptor beta-1 (ADRB1) DMUKGEA MT DTT DMUKGEA MA Antagonist DMUKGEA RN Current therapeutic uses and potential of beta-adrenoceptor agonists and antagonists. Eur J Clin Pharmacol. 1998 Feb;53(6):389-404. DMUKGEA RU https://pubmed.ncbi.nlm.nih.gov/9551698 DMRYX1P DI DMRYX1P DMRYX1P DN CEL-1000 DMRYX1P MI TTN2JFW DMRYX1P MN T-cell surface glycoprotein CD4 (CD4) DMRYX1P MT DTT DMRYX1P RN A small peptide (CEL-1000) derived from the beta-chain of the human major histocompatibility complex class II molecule induces complete protection against malaria in an antigen-independent manner. Antimicrob Agents Chemother. 2004 Jul;48(7):2455-63. DMRYX1P RU https://pubmed.ncbi.nlm.nih.gov/15215094 DMQ0HCT DI DMQ0HCT DMQ0HCT DN CEM-301 DMQ0HCT MI TT953CX DMQ0HCT MN Motilin receptor (MLNR) DMQ0HCT MT DTT DMQ0HCT MA Agonist DMQ0HCT RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 297). DMQ0HCT RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=297 DMCLXO0 DI DMCLXO0 DMCLXO0 DN CENTAUREIDIN DMCLXO0 MI TTML2WA DMCLXO0 MN Tubulin (TUB) DMCLXO0 MT DTT DMCLXO0 MA Inhibitor DMCLXO0 RN Structure-activity requirements for flavone cytotoxicity and binding to tubulin. J Med Chem. 1998 Jun 18;41(13):2333-8. DMCLXO0 RU https://pubmed.ncbi.nlm.nih.gov/9632366 DMCLXO0 DI DMCLXO0 DMCLXO0 DN CENTAUREIDIN DMCLXO0 MI TTYFKSZ DMCLXO0 MN Tubulin beta (TUBB) DMCLXO0 MT DTT DMCLXO0 MA Inhibitor DMCLXO0 RN Structure-activity requirements for flavone cytotoxicity and binding to tubulin. J Med Chem. 1998 Jun 18;41(13):2333-8. DMCLXO0 RU https://pubmed.ncbi.nlm.nih.gov/9632366 DMOHELX DI DMOHELX DMOHELX DN Centratherin DMOHELX MI TTSXVID DMOHELX MN Nuclear factor NF-kappa-B (NFKB) DMOHELX MT DTT DMOHELX MA Inhibitor DMOHELX RN Development of a structural model for NF-kappaB inhibition of sesquiterpene lactones using self-organizing neural networks. J Med Chem. 2006 Apr 6;49(7):2241-52. DMOHELX RU https://pubmed.ncbi.nlm.nih.gov/16570920 DMA7JO4 DI DMA7JO4 DMA7JO4 DN CEP1348 DMA7JO4 MI TT9FN4J DMA7JO4 MN Mixed lineage kinase 2 (MAP3K10) DMA7JO4 MT DTT DMA7JO4 MA Inhibitor DMA7JO4 RN Pharmacological inhibitors of MAPK pathways. Trends Pharmacol Sci. 2002 Jan;23(1):40-5. DMA7JO4 RU https://pubmed.ncbi.nlm.nih.gov/11804650 DMOAZX5 DI DMOAZX5 DMOAZX5 DN CEP1349 DMOAZX5 MI TTETX6Q DMOAZX5 MN Mixed lineage kinase 3 (MAP3K11) DMOAZX5 MT DTT DMOAZX5 MA Inhibitor DMOAZX5 RN Pharmacological inhibitors of MAPK pathways. Trends Pharmacol Sci. 2002 Jan;23(1):40-5. DMOAZX5 RU https://pubmed.ncbi.nlm.nih.gov/11804650 DMCIOSM DI DMCIOSM DMCIOSM DN CEP-18050 DMCIOSM MI TTPMQSO DMCIOSM MN ALK tyrosine kinase receptor (ALK) DMCIOSM MT DTT DMCIOSM MA Inhibitor DMCIOSM RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1839). DMCIOSM RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1839 DMAY04M DI DMAY04M DMAY04M DN CEP-28122 DMAY04M MI TTPMQSO DMAY04M MN ALK tyrosine kinase receptor (ALK) DMAY04M MT DTT DMAY04M MA Inhibitor DMAY04M RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1839). DMAY04M RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1839 DMV43GY DI DMV43GY DMV43GY DN CEP-5104 DMV43GY MI TT2B9KF DMV43GY MN Fyn tyrosine protein kinase (FYN) DMV43GY MT DTT DMV43GY MA Inhibitor DMV43GY RN Mixed-lineage kinase 1 and mixed-lineage kinase 3 subtype-selective dihydronaphthyl[3,4-a]pyrrolo[3,4-c]carbazole-5-ones: optimization, mixed-linea... J Med Chem. 2008 Sep 25;51(18):5680-9. DMV43GY RU https://pubmed.ncbi.nlm.nih.gov/18714982 DMV43GY DI DMV43GY DMV43GY DN CEP-5104 DMV43GY MI TT860QF DMV43GY MN LCK tyrosine protein kinase (LCK) DMV43GY MT DTT DMV43GY MA Inhibitor DMV43GY RN Mixed-lineage kinase 1 and mixed-lineage kinase 3 subtype-selective dihydronaphthyl[3,4-a]pyrrolo[3,4-c]carbazole-5-ones: optimization, mixed-linea... J Med Chem. 2008 Sep 25;51(18):5680-9. DMV43GY RU https://pubmed.ncbi.nlm.nih.gov/18714982 DMV43GY DI DMV43GY DMV43GY DN CEP-5104 DMV43GY MI TTUNSIX DMV43GY MN Mixed lineage kinase 1 (MAP3K9) DMV43GY MT DTT DMV43GY MA Inhibitor DMV43GY RN Mixed-lineage kinase 1 and mixed-lineage kinase 3 subtype-selective dihydronaphthyl[3,4-a]pyrrolo[3,4-c]carbazole-5-ones: optimization, mixed-linea... J Med Chem. 2008 Sep 25;51(18):5680-9. DMV43GY RU https://pubmed.ncbi.nlm.nih.gov/18714982 DMV43GY DI DMV43GY DMV43GY DN CEP-5104 DMV43GY MI TT9FN4J DMV43GY MN Mixed lineage kinase 2 (MAP3K10) DMV43GY MT DTT DMV43GY MA Inhibitor DMV43GY RN Mixed-lineage kinase 1 and mixed-lineage kinase 3 subtype-selective dihydronaphthyl[3,4-a]pyrrolo[3,4-c]carbazole-5-ones: optimization, mixed-linea... J Med Chem. 2008 Sep 25;51(18):5680-9. DMV43GY RU https://pubmed.ncbi.nlm.nih.gov/18714982 DMV43GY DI DMV43GY DMV43GY DN CEP-5104 DMV43GY MI TTETX6Q DMV43GY MN Mixed lineage kinase 3 (MAP3K11) DMV43GY MT DTT DMV43GY MA Inhibitor DMV43GY RN Mixed-lineage kinase 1 and mixed-lineage kinase 3 subtype-selective dihydronaphthyl[3,4-a]pyrrolo[3,4-c]carbazole-5-ones: optimization, mixed-linea... J Med Chem. 2008 Sep 25;51(18):5680-9. DMV43GY RU https://pubmed.ncbi.nlm.nih.gov/18714982 DMV43GY DI DMV43GY DMV43GY DN CEP-5104 DMV43GY MI TTTDVOJ DMV43GY MN Tropomyosin-related kinase A (TrkA) DMV43GY MT DTT DMV43GY MA Inhibitor DMV43GY RN Mixed-lineage kinase 1 and mixed-lineage kinase 3 subtype-selective dihydronaphthyl[3,4-a]pyrrolo[3,4-c]carbazole-5-ones: optimization, mixed-linea... J Med Chem. 2008 Sep 25;51(18):5680-9. DMV43GY RU https://pubmed.ncbi.nlm.nih.gov/18714982 DMV43GY DI DMV43GY DMV43GY DN CEP-5104 DMV43GY MI TTUTJGQ DMV43GY MN Vascular endothelial growth factor receptor 2 (KDR) DMV43GY MT DTT DMV43GY MA Inhibitor DMV43GY RN Mixed-lineage kinase 1 and mixed-lineage kinase 3 subtype-selective dihydronaphthyl[3,4-a]pyrrolo[3,4-c]carbazole-5-ones: optimization, mixed-linea... J Med Chem. 2008 Sep 25;51(18):5680-9. DMV43GY RU https://pubmed.ncbi.nlm.nih.gov/18714982 DMNXBTD DI DMNXBTD DMNXBTD DN CEP-6331 DMNXBTD MI TT2B9KF DMNXBTD MN Fyn tyrosine protein kinase (FYN) DMNXBTD MT DTT DMNXBTD MA Inhibitor DMNXBTD RN Mixed-lineage kinase 1 and mixed-lineage kinase 3 subtype-selective dihydronaphthyl[3,4-a]pyrrolo[3,4-c]carbazole-5-ones: optimization, mixed-linea... J Med Chem. 2008 Sep 25;51(18):5680-9. DMNXBTD RU https://pubmed.ncbi.nlm.nih.gov/18714982 DMNXBTD DI DMNXBTD DMNXBTD DN CEP-6331 DMNXBTD MI TTUNSIX DMNXBTD MN Mixed lineage kinase 1 (MAP3K9) DMNXBTD MT DTT DMNXBTD MA Inhibitor DMNXBTD RN Mixed-lineage kinase 1 and mixed-lineage kinase 3 subtype-selective dihydronaphthyl[3,4-a]pyrrolo[3,4-c]carbazole-5-ones: optimization, mixed-linea... J Med Chem. 2008 Sep 25;51(18):5680-9. DMNXBTD RU https://pubmed.ncbi.nlm.nih.gov/18714982 DMNXBTD DI DMNXBTD DMNXBTD DN CEP-6331 DMNXBTD MI TT9FN4J DMNXBTD MN Mixed lineage kinase 2 (MAP3K10) DMNXBTD MT DTT DMNXBTD MA Inhibitor DMNXBTD RN Mixed-lineage kinase 1 and mixed-lineage kinase 3 subtype-selective dihydronaphthyl[3,4-a]pyrrolo[3,4-c]carbazole-5-ones: optimization, mixed-linea... J Med Chem. 2008 Sep 25;51(18):5680-9. DMNXBTD RU https://pubmed.ncbi.nlm.nih.gov/18714982 DMNXBTD DI DMNXBTD DMNXBTD DN CEP-6331 DMNXBTD MI TTETX6Q DMNXBTD MN Mixed lineage kinase 3 (MAP3K11) DMNXBTD MT DTT DMNXBTD MA Inhibitor DMNXBTD RN Mixed-lineage kinase 1 and mixed-lineage kinase 3 subtype-selective dihydronaphthyl[3,4-a]pyrrolo[3,4-c]carbazole-5-ones: optimization, mixed-linea... J Med Chem. 2008 Sep 25;51(18):5680-9. DMNXBTD RU https://pubmed.ncbi.nlm.nih.gov/18714982 DMNXBTD DI DMNXBTD DMNXBTD DN CEP-6331 DMNXBTD MI TTTDVOJ DMNXBTD MN Tropomyosin-related kinase A (TrkA) DMNXBTD MT DTT DMNXBTD MA Inhibitor DMNXBTD RN Mixed-lineage kinase 1 and mixed-lineage kinase 3 subtype-selective dihydronaphthyl[3,4-a]pyrrolo[3,4-c]carbazole-5-ones: optimization, mixed-linea... J Med Chem. 2008 Sep 25;51(18):5680-9. DMNXBTD RU https://pubmed.ncbi.nlm.nih.gov/18714982 DMNXBTD DI DMNXBTD DMNXBTD DN CEP-6331 DMNXBTD MI TTDCBX5 DMNXBTD MN Vascular endothelial growth factor receptor 3 (FLT-4) DMNXBTD MT DTT DMNXBTD MA Inhibitor DMNXBTD RN Mixed-lineage kinase 1 and mixed-lineage kinase 3 subtype-selective dihydronaphthyl[3,4-a]pyrrolo[3,4-c]carbazole-5-ones: optimization, mixed-linea... J Med Chem. 2008 Sep 25;51(18):5680-9. DMNXBTD RU https://pubmed.ncbi.nlm.nih.gov/18714982 DMS16BD DI DMS16BD DMS16BD DN CEP-6800 DMS16BD MI TTVDSZ0 DMS16BD MN Poly [ADP-ribose] polymerase 1 (PARP1) DMS16BD MT DTT DMS16BD MA Inhibitor DMS16BD RN Novel poly(ADP-ribose) polymerase-1 inhibitors. Bioorg Med Chem Lett. 2007 Jan 15;17(2):542-5. DMS16BD RU https://pubmed.ncbi.nlm.nih.gov/17074482 DMYW3ZG DI DMYW3ZG DMYW3ZG DN Cephalosporin C DMYW3ZG MI TTLP6GN DMYW3ZG MN Bacterial DD-carboxypeptidase (Bact vanYB) DMYW3ZG MT DTT DMYW3ZG MA Inhibitor DMYW3ZG RN DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Nucleic Acids Res. 2011 Jan;39(Database issue):D1035-41. DMYW3ZG RU https://pubmed.ncbi.nlm.nih.gov/21059682 DMYW3ZG DI DMYW3ZG DMYW3ZG DN Cephalosporin C DMYW3ZG MI TT85JMW DMYW3ZG MN Bacterial Penicillin binding protein 3 (Bact mrcA) DMYW3ZG MT DTT DMYW3ZG MA Antagonist DMYW3ZG RN DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Nucleic Acids Res. 2011 Jan;39(Database issue):D1035-41. DMYW3ZG RU https://pubmed.ncbi.nlm.nih.gov/21059682 DMYW3ZG DI DMYW3ZG DMYW3ZG DN Cephalosporin C DMYW3ZG MI TT329FH DMYW3ZG MN Bacterial Penicillin-binding protein 1B (Bact mrcB) DMYW3ZG MT DTT DMYW3ZG MA Antagonist DMYW3ZG RN DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Nucleic Acids Res. 2011 Jan;39(Database issue):D1035-41. DMYW3ZG RU https://pubmed.ncbi.nlm.nih.gov/21059682 DMCE3NA DI DMCE3NA DMCE3NA DN CEPHARANTINE DMCE3NA MI TTRTKPV DMCE3NA MN Trypanosoma Trypanothione reductase (Trypano TPR) DMCE3NA MT DTT DMCE3NA MA Inhibitor DMCE3NA RN The use of natural product scaffolds as leads in the search for trypanothione reductase inhibitors. Bioorg Med Chem. 2008 Jul 15;16(14):6689-95. DMCE3NA RU https://pubmed.ncbi.nlm.nih.gov/18558492 DMY8LBO DI DMY8LBO DMY8LBO DN Ceplene/Peg-Intron/Rebetol DMY8LBO MI TTSYFMA DMY8LBO MN Interferon alpha/beta receptor 1 (IFNAR1) DMY8LBO MT DTT DMY8LBO MA Modulator DMY8LBO RN Resistance to mericitabine, a nucleoside analogue inhibitor of HCV RNA-dependent RNA polymerase. Antivir Ther. 2012;17(3):411-23. DMY8LBO RU https://pubmed.ncbi.nlm.nih.gov/22402762 DMSL4FQ DI DMSL4FQ DMSL4FQ DN CFGGFTCARKSARK DMSL4FQ MI TTNT7K8 DMSL4FQ MN Nociceptin receptor (OPRL1) DMSL4FQ MT DTT DMSL4FQ MA Inhibitor DMSL4FQ RN Structure-activity studies on nociceptin analogues: ORL1 receptor binding and biological activity of cyclic disulfide-containing analogues of nocic... J Med Chem. 2001 Nov 8;44(23):4015-8. DMSL4FQ RU https://pubmed.ncbi.nlm.nih.gov/11689089 DM2B0RX DI DM2B0RX DM2B0RX DN CFGGFTGARKCARK DM2B0RX MI TTNT7K8 DM2B0RX MN Nociceptin receptor (OPRL1) DM2B0RX MT DTT DM2B0RX MA Inhibitor DM2B0RX RN Structure-activity studies on nociceptin analogues: ORL1 receptor binding and biological activity of cyclic disulfide-containing analogues of nocic... J Med Chem. 2001 Nov 8;44(23):4015-8. DM2B0RX RU https://pubmed.ncbi.nlm.nih.gov/11689089 DMN8B1S DI DMN8B1S DMN8B1S DN CFMMC DMN8B1S MI TTVBPDM DMN8B1S MN Metabotropic glutamate receptor 1 (mGluR1) DMN8B1S MT DTT DMN8B1S MA Modulator (allosteric modulator) DMN8B1S RN Identification of a novel transmembrane domain involved in the negative modulation of mGluR1 using a newly discovered allosteric mGluR1 antagonist, 3-cyclohexyl-5-fluoro-6-methyl-7-(2-morpholin-4-ylethoxy)-4H-chromen-4-one. Neuropharmacology. 2009 Sep;57(4):438-45. DMN8B1S RU https://pubmed.ncbi.nlm.nih.gov/19559036 DM9HMP4 DI DM9HMP4 DM9HMP4 DN CFMTI DM9HMP4 MI TTVBPDM DM9HMP4 MN Metabotropic glutamate receptor 1 (mGluR1) DM9HMP4 MT DTT DM9HMP4 MA Modulator (allosteric modulator) DM9HMP4 RN Unique antipsychotic activities of the selective metabotropic glutamate receptor 1 allosteric antagonist 2-cyclopropyl-5-[1-(2-fluoro-3-pyridinyl)-5-methyl-1H-1,2,3-triazol-4-yl]-2,3-dihydro-1H-isoindol-1-one. J Pharmacol Exp Ther. 2009 Jul;330(1):179-90. DM9HMP4 RU https://pubmed.ncbi.nlm.nih.gov/19359526 DM8TJW3 DI DM8TJW3 DM8TJW3 DN CFTRinh-172 DM8TJW3 MI TTRLZHP DM8TJW3 MN cAMP-dependent chloride channel (CFTR) DM8TJW3 MT DTT DM8TJW3 MA Blocker (channel blocker) DM8TJW3 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 707). DM8TJW3 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=707 DMGW9QL DI DMGW9QL DMGW9QL DN CG-103065 DMGW9QL MI TTOU65C DMGW9QL MN Tyrosine-protein kinase SYK (SYK) DMGW9QL MT DTT DMGW9QL MA Inhibitor DMGW9QL RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2230). DMGW9QL RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2230 DMN3YEQ DI DMN3YEQ DMN3YEQ DN CG-1521 DMN3YEQ MI TTBH0VX DMN3YEQ MN Histone deacetylase (HDAC) DMN3YEQ MT DTT DMN3YEQ MA Inhibitor DMN3YEQ RN Anticancer activities of histone deacetylase inhibitors. Nat Rev Drug Discov. 2006 Sep;5(9):769-84. DMN3YEQ RU https://pubmed.ncbi.nlm.nih.gov/16955068 DM4FMPJ DI DM4FMPJ DM4FMPJ DN CGEN-855 DM4FMPJ MI TT5Y4EM DM4FMPJ MN N-formyl peptide receptor (FPR1) DM4FMPJ MT DTT DM4FMPJ MA Agonist DM4FMPJ RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 222). DM4FMPJ RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=222 DMTPRBX DI DMTPRBX DMTPRBX DN CGI-1316 DMTPRBX MI TTGM6VW DMTPRBX MN Tyrosine-protein kinase BTK (ATK) DMTPRBX MT DTT DMTPRBX MA Inhibitor DMTPRBX RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1948). DMTPRBX RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1948 DM8OAN9 DI DM8OAN9 DM8OAN9 DN CGK733 DM8OAN9 MI TTKBM7V DM8OAN9 MN ATM serine/threonine kinase (ATM) DM8OAN9 MT DTT DM8OAN9 MA Inhibitor DM8OAN9 RN Small molecule-based reversible reprogramming of cellular lifespan. Nat Chem Biol. 2006 Jul;2(7):369-74. DM8OAN9 RU https://pubmed.ncbi.nlm.nih.gov/16767085 DM8OAN9 DI DM8OAN9 DM8OAN9 DN CGK733 DM8OAN9 MI TT8ZYBQ DM8OAN9 MN Serine/threonine-protein kinase ATR (FRP1) DM8OAN9 MT DTT DM8OAN9 MA Inhibitor DM8OAN9 RN Small molecule-based reversible reprogramming of cellular lifespan. Nat Chem Biol. 2006 Jul;2(7):369-74. DM8OAN9 RU https://pubmed.ncbi.nlm.nih.gov/16767085 DMQ3SAY DI DMQ3SAY DMQ3SAY DN CGNLSTCBLGTYTQDF[DKFHO]YPQTAIGVGAP-amide DMQ3SAY MI TTLWS2O DMQ3SAY MN Calcitonin receptor (CALCR) DMQ3SAY MT DTT DMQ3SAY MA Inhibitor DMQ3SAY RN Side-chain lactam-bridge conformational constraints differentiate the activities of salmon and human calcitonins and reveal a new design concept fo... J Med Chem. 2002 Feb 28;45(5):1108-21. DMQ3SAY RU https://pubmed.ncbi.nlm.nih.gov/11855991 DMLA384 DI DMLA384 DMLA384 DN CGNLSTCBLGTYTQDFNKFHZYPQTAIGVGAP-amide DMLA384 MI TTLWS2O DMLA384 MN Calcitonin receptor (CALCR) DMLA384 MT DTT DMLA384 MA Inhibitor DMLA384 RN Side-chain lactam-bridge conformational constraints differentiate the activities of salmon and human calcitonins and reveal a new design concept fo... J Med Chem. 2002 Feb 28;45(5):1108-21. DMLA384 RU https://pubmed.ncbi.nlm.nih.gov/11855991 DMUGAYT DI DMUGAYT DMUGAYT DN CGNLSTCMLGTYTQDFc[DKFHK]FPQTAIGVGAP-amide DMUGAYT MI TTLWS2O DMUGAYT MN Calcitonin receptor (CALCR) DMUGAYT MT DTT DMUGAYT MA Inhibitor DMUGAYT RN Side-chain lactam-bridge conformational constraints differentiate the activities of salmon and human calcitonins and reveal a new design concept fo... J Med Chem. 2002 Feb 28;45(5):1108-21. DMUGAYT RU https://pubmed.ncbi.nlm.nih.gov/11855991 DM3FP47 DI DM3FP47 DM3FP47 DN CGNLSTCMLGTYTQDFc[DKFHO]FPQTAIGVGAP-amide DM3FP47 MI TTLWS2O DM3FP47 MN Calcitonin receptor (CALCR) DM3FP47 MT DTT DM3FP47 MA Inhibitor DM3FP47 RN Side-chain lactam-bridge conformational constraints differentiate the activities of salmon and human calcitonins and reveal a new design concept fo... J Med Chem. 2002 Feb 28;45(5):1108-21. DM3FP47 RU https://pubmed.ncbi.nlm.nih.gov/11855991 DMJ9Z31 DI DMJ9Z31 DMJ9Z31 DN CGNLSTCMLGTYTQDFNKFHTFPQTAIGVGAP-amide DMJ9Z31 MI TTLWS2O DMJ9Z31 MN Calcitonin receptor (CALCR) DMJ9Z31 MT DTT DMJ9Z31 MA Inhibitor DMJ9Z31 RN Side-chain lactam-bridge conformational constraints differentiate the activities of salmon and human calcitonins and reveal a new design concept fo... J Med Chem. 2002 Feb 28;45(5):1108-21. DMJ9Z31 RU https://pubmed.ncbi.nlm.nih.gov/11855991 DME84PN DI DME84PN DME84PN DN CGNLSTCMLGTYTQDFNKPHTFPQTAIGVGAP-amide DME84PN MI TTLWS2O DME84PN MN Calcitonin receptor (CALCR) DME84PN MT DTT DME84PN MA Inhibitor DME84PN RN Side-chain lactam-bridge conformational constraints differentiate the activities of salmon and human calcitonins and reveal a new design concept fo... J Med Chem. 2002 Feb 28;45(5):1108-21. DME84PN RU https://pubmed.ncbi.nlm.nih.gov/11855991 DMV7TE4 DI DMV7TE4 DMV7TE4 DN CGNLSTCMLGTYTQDFNPFHTFPQTAIGVGAP-amide DMV7TE4 MI TTLWS2O DMV7TE4 MN Calcitonin receptor (CALCR) DMV7TE4 MT DTT DMV7TE4 MA Inhibitor DMV7TE4 RN Side-chain lactam-bridge conformational constraints differentiate the activities of salmon and human calcitonins and reveal a new design concept fo... J Med Chem. 2002 Feb 28;45(5):1108-21. DMV7TE4 RU https://pubmed.ncbi.nlm.nih.gov/11855991 DMMO8A2 DI DMMO8A2 DMMO8A2 DN CGNLSTCMLGTYTQDFNPKHTFPQTAIGVGAP-amide DMMO8A2 MI TTLWS2O DMMO8A2 MN Calcitonin receptor (CALCR) DMMO8A2 MT DTT DMMO8A2 MA Inhibitor DMMO8A2 RN Side-chain lactam-bridge conformational constraints differentiate the activities of salmon and human calcitonins and reveal a new design concept fo... J Med Chem. 2002 Feb 28;45(5):1108-21. DMMO8A2 RU https://pubmed.ncbi.nlm.nih.gov/11855991 DML79NU DI DML79NU DML79NU DN CGP 20712A DML79NU MI TTR6W5O DML79NU MN Adrenergic receptor beta-1 (ADRB1) DML79NU MT DTT DML79NU MA Antagonist DML79NU RN Distribution of beta 1- and beta 2-adrenoceptor subtypes in various mouse tissues. Neurosci Lett. 1993 Sep 17;160(1):96-100. DML79NU RU https://pubmed.ncbi.nlm.nih.gov/7902545 DMTECXA DI DMTECXA DMTECXA DN CGP 23996 DMTECXA MI TTIND6G DMTECXA MN Somatostatin receptor type 1 (SSTR1) DMTECXA MT DTT DMTECXA MA Agonist DMTECXA RN Characterisation of human recombinant somatostatin receptors. 1. Radioligand binding studies. Naunyn Schmiedebergs Arch Pharmacol. 1999 Nov;360(5):488-99. DMTECXA RU https://pubmed.ncbi.nlm.nih.gov/10598788 DMTECXA DI DMTECXA DMTECXA DN CGP 23996 DMTECXA MI TTZ6T9E DMTECXA MN Somatostatin receptor type 2 (SSTR2) DMTECXA MT DTT DMTECXA MA Agonist DMTECXA RN [125I][Tyr3]octreotide labels human somatostatin sst2 and sst5 receptors. Eur J Pharmacol. 1998 May 8;348(2-3):311-20. DMTECXA RU https://pubmed.ncbi.nlm.nih.gov/9652348 DMTECXA DI DMTECXA DMTECXA DN CGP 23996 DMTECXA MI TTJX3UE DMTECXA MN Somatostatin receptor type 3 (SSTR3) DMTECXA MT DTT DMTECXA MA Agonist DMTECXA RN Characterisation of human recombinant somatostatin receptors. 1. Radioligand binding studies. Naunyn Schmiedebergs Arch Pharmacol. 1999 Nov;360(5):488-99. DMTECXA RU https://pubmed.ncbi.nlm.nih.gov/10598788 DMTECXA DI DMTECXA DMTECXA DN CGP 23996 DMTECXA MI TTAE1BR DMTECXA MN Somatostatin receptor type 4 (SSTR4) DMTECXA MT DTT DMTECXA MA Agonist DMTECXA RN Characterisation of human recombinant somatostatin receptors. 1. Radioligand binding studies. Naunyn Schmiedebergs Arch Pharmacol. 1999 Nov;360(5):488-99. DMTECXA RU https://pubmed.ncbi.nlm.nih.gov/10598788 DMTECXA DI DMTECXA DMTECXA DN CGP 23996 DMTECXA MI TT2BC4G DMTECXA MN Somatostatin receptor type 5 (SSTR5) DMTECXA MT DTT DMTECXA MA Agonist DMTECXA RN [125I][Tyr3]octreotide labels human somatostatin sst2 and sst5 receptors. Eur J Pharmacol. 1998 May 8;348(2-3):311-20. DMTECXA RU https://pubmed.ncbi.nlm.nih.gov/9652348 DMEA5BZ DI DMEA5BZ DMEA5BZ DN CGP 40336A DMEA5BZ MI TTT3ZC9 DMEA5BZ MN Human immunodeficiency virus Tat protein (HIV tat) DMEA5BZ MT DTT DMEA5BZ MA Inhibitor DMEA5BZ RN RNA as a target for small molecules. Curr Opin Chem Biol. 2000 Dec;4(6):678-86. DMEA5BZ RU https://pubmed.ncbi.nlm.nih.gov/11102874 DMXV6RD DI DMXV6RD DMXV6RD DN CGP 46381 DMXV6RD MI TTDCVZW DMXV6RD MN Gamma-aminobutyric acid B receptor (GABBR) DMXV6RD MT DTT DMXV6RD MA Antagonist DMXV6RD RN The human GABA(B1b) and GABA(B2) heterodimeric recombinant receptor shows low sensitivity to phaclofen and saclofen. Br J Pharmacol. 2000 Nov;131(6):1050-4. DMXV6RD RU https://pubmed.ncbi.nlm.nih.gov/11082110 DME39UQ DI DME39UQ DME39UQ DN CGP 47656 DME39UQ MI TTDCVZW DME39UQ MN Gamma-aminobutyric acid B receptor (GABBR) DME39UQ MT DTT DME39UQ MA Agonist DME39UQ RN Expression cloning of GABA(B) receptors uncovers similarity to metabotropic glutamate receptors. Nature. 1997 Mar 20;386(6622):239-46. DME39UQ RU https://pubmed.ncbi.nlm.nih.gov/9069281 DMEHYVS DI DMEHYVS DMEHYVS DN CGP 54626A DMEHYVS MI TTDCVZW DMEHYVS MN Gamma-aminobutyric acid B receptor (GABBR) DMEHYVS MT DTT DMEHYVS MA Antagonist DMEHYVS RN GABA(B) receptors function as a heteromeric assembly of the subunits GABA(B)R1 and GABA(B)R2. Nature. 1998 Dec 17;396(6712):674-9. DMEHYVS RU https://pubmed.ncbi.nlm.nih.gov/9872315 DMNMG0I DI DMNMG0I DMNMG0I DN CGP 55845 DMNMG0I MI TTDCVZW DMNMG0I MN Gamma-aminobutyric acid B receptor (GABBR) DMNMG0I MT DTT DMNMG0I MA Antagonist DMNMG0I RN The human GABA(B1b) and GABA(B2) heterodimeric recombinant receptor shows low sensitivity to phaclofen and saclofen. Br J Pharmacol. 2000 Nov;131(6):1050-4. DMNMG0I RU https://pubmed.ncbi.nlm.nih.gov/11082110 DMR708D DI DMR708D DMR708D DN CGP 56999A DMR708D MI TTDCVZW DMR708D MN Gamma-aminobutyric acid B receptor (GABBR) DMR708D MT DTT DMR708D MA Antagonist DMR708D RN Expression cloning of GABA(B) receptors uncovers similarity to metabotropic glutamate receptors. Nature. 1997 Mar 20;386(6622):239-46. DMR708D RU https://pubmed.ncbi.nlm.nih.gov/9069281 DMYXE39 DI DMYXE39 DMYXE39 DN CGP 62349 DMYXE39 MI TTDCVZW DMYXE39 MN Gamma-aminobutyric acid B receptor (GABBR) DMYXE39 MT DTT DMYXE39 MA Antagonist DMYXE39 RN Characterisation and partial purification of the GABA(B) receptor from the rat cerebellum using the novel antagonist [3H]CGP 62349. Brain Res Mol Brain Res. 1999 Aug 25;71(2):279-89. DMYXE39 RU https://pubmed.ncbi.nlm.nih.gov/10521582 DMR8U1M DI DMR8U1M DMR8U1M DN CGP 64213 DMR8U1M MI TTDCVZW DMR8U1M MN Gamma-aminobutyric acid B receptor (GABBR) DMR8U1M MT DTT DMR8U1M MA Antagonist DMR8U1M RN Expression cloning of GABA(B) receptors uncovers similarity to metabotropic glutamate receptors. Nature. 1997 Mar 20;386(6622):239-46. DMR8U1M RU https://pubmed.ncbi.nlm.nih.gov/9069281 DMJWED7 DI DMJWED7 DMJWED7 DN CGP 71872 DMJWED7 MI TTDCVZW DMJWED7 MN Gamma-aminobutyric acid B receptor (GABBR) DMJWED7 MT DTT DMJWED7 MA Antagonist DMJWED7 RN Expression cloning of GABA(B) receptors uncovers similarity to metabotropic glutamate receptors. Nature. 1997 Mar 20;386(6622):239-46. DMJWED7 RU https://pubmed.ncbi.nlm.nih.gov/9069281 DMXH2R3 DI DMXH2R3 DMXH2R3 DN CGP 77675 DMXH2R3 MI TT6PKBN DMXH2R3 MN Proto-oncogene c-Src (SRC) DMXH2R3 MT DTT DMXH2R3 MA Inhibitor DMXH2R3 RN A novel inhibitor of the tyrosine kinase Src suppresses phosphorylation of its major cellular substrates and reduces bone resorption in vitro and in rodent models in vivo. Bone. 1999 May;24(5):437-49. DMXH2R3 RU https://pubmed.ncbi.nlm.nih.gov/10321903 DMNUQAG DI DMNUQAG DMNUQAG DN CGP-029482 DMNUQAG MI TTER6YH DMNUQAG MN Casein kinase II alpha (CSNK2A1) DMNUQAG MT DTT DMNUQAG MA Inhibitor DMNUQAG RN Structural insight into human CK2alpha in complex with the potent inhibitor ellagic acid. Bioorg Med Chem Lett. 2009 Jun 1;19(11):2920-3. DMNUQAG RU https://pubmed.ncbi.nlm.nih.gov/19414254 DMCE6WJ DI DMCE6WJ DMCE6WJ DN CGP-191 DMCE6WJ MI TT6PKBN DMCE6WJ MN Proto-oncogene c-Src (SRC) DMCE6WJ MT DTT DMCE6WJ MA Inhibitor DMCE6WJ RN Substituted 5,7-diphenyl-pyrrolo[2,3d]pyrimidines: potent inhibitors of the tyrosine kinase c-Src. Bioorg Med Chem Lett. 2000 May 1;10(9):945-9. DMCE6WJ RU https://pubmed.ncbi.nlm.nih.gov/10853665 DMS61KA DI DMS61KA DMS61KA DN CGP-29030A DMS61KA MI TTDCVZW DMS61KA MN Gamma-aminobutyric acid B receptor (GABBR) DMS61KA MT DTT DMS61KA MA Modulator DMS61KA RN Effects of a novel piperazine derivative (CGP 29030A) on nociceptive dorsal horn neurons in the rat. Drugs Exp Clin Res. 1992;18(11-12):447-59. DMS61KA RU https://pubmed.ncbi.nlm.nih.gov/1308469 DM84TSH DI DM84TSH DM84TSH DN CGP-34938 DM84TSH MI TTDCVZW DM84TSH MN Gamma-aminobutyric acid B receptor (GABBR) DM84TSH MT DTT DM84TSH MA Inhibitor DM84TSH RN Phosphinic acid analogues of GABA. 1. New potent and selective GABAB agonists. J Med Chem. 1995 Aug 18;38(17):3297-312. DM84TSH RU https://pubmed.ncbi.nlm.nih.gov/7650684 DMHKETG DI DMHKETG DMHKETG DN CGP-35024 DMHKETG MI TTDCVZW DMHKETG MN Gamma-aminobutyric acid B receptor (GABBR) DMHKETG MT DTT DMHKETG MA Inhibitor DMHKETG RN Inhibition of transient LES relaxations and reflux in ferrets by GABA receptor agonists. Am J Physiol. 1999 Oct;277(4 Pt 1):G867-74. DMHKETG RU https://pubmed.ncbi.nlm.nih.gov/10516154 DM3J6HM DI DM3J6HM DM3J6HM DN CGP-35582 DM3J6HM MI TTDCVZW DM3J6HM MN Gamma-aminobutyric acid B receptor (GABBR) DM3J6HM MT DTT DM3J6HM MA Inhibitor DM3J6HM RN Phosphinic acid analogues of GABA. 1. New potent and selective GABAB agonists. J Med Chem. 1995 Aug 18;38(17):3297-312. DM3J6HM RU https://pubmed.ncbi.nlm.nih.gov/7650684 DM9U8TO DI DM9U8TO DM9U8TO DN CGP-36216 DM9U8TO MI TTDCVZW DM9U8TO MN Gamma-aminobutyric acid B receptor (GABBR) DM9U8TO MT DTT DM9U8TO MA Inhibitor DM9U8TO RN Biological activity of 3-aminopropyl (methyl) phosphinic acid, a potent and selective GABAB agonist with CNS activity, Bioorg. Med. Chem. Lett. 3(4):515-518 (1993). DM9U8TO RU http://www.sciencedirect.com/science/article/pii/S0960894X0181218X DMKF0GH DI DMKF0GH DMKF0GH DN CGP-44532 DMKF0GH MI TTDCVZW DMKF0GH MN Gamma-aminobutyric acid B receptor (GABBR) DMKF0GH MT DTT DMKF0GH MA Agonist DMKF0GH RN Glutamate- and GABA-based CNS therapeutics. Curr Opin Pharmacol. 2006 Feb;6(1):7-17. DMKF0GH RU https://pubmed.ncbi.nlm.nih.gov/16377242 DM5SATN DI DM5SATN DM5SATN DN CGP-49870 DM5SATN MI TT8DBY3 DM5SATN MN Angiotensin II receptor type-1 (AGTR1) DM5SATN MT DTT DM5SATN MA Modulator DM5SATN RN Pharmaceutical compositions comprising NEP-inhibitors, inhibitors of the endogenous endothelin producing system and AT1 receptor antagonists DM5SATN RU https://www.google.com/patents/US20050288272 DMFPOUC DI DMFPOUC DMFPOUC DN CGP-57380 DMFPOUC MI TT9RTBL DMFPOUC MN Aurora B messenger RNA (AURKB mRNA) DMFPOUC MT DTT DMFPOUC MA Inhibitor DMFPOUC RN The selectivity of protein kinase inhibitors: a further update. Biochem J. 2007 Dec 15;408(3):297-315. DMFPOUC RU https://pubmed.ncbi.nlm.nih.gov/17850214 DMFPOUC DI DMFPOUC DMFPOUC DN CGP-57380 DMFPOUC MI TT860QF DMFPOUC MN LCK tyrosine protein kinase (LCK) DMFPOUC MT DTT DMFPOUC MA Inhibitor DMFPOUC RN The selectivity of protein kinase inhibitors: a further update. Biochem J. 2007 Dec 15;408(3):297-315. DMFPOUC RU https://pubmed.ncbi.nlm.nih.gov/17850214 DMFPOUC DI DMFPOUC DMFPOUC DN CGP-57380 DMFPOUC MI TTTV8EJ DMFPOUC MN Serine/threonine-protein kinase Sgk1 (SGK1) DMFPOUC MT DTT DMFPOUC MA Inhibitor DMFPOUC RN The selectivity of protein kinase inhibitors: a further update. Biochem J. 2007 Dec 15;408(3):297-315. DMFPOUC RU https://pubmed.ncbi.nlm.nih.gov/17850214 DMYZ72J DI DMYZ72J DMYZ72J DN CGP-57698 DMYZ72J MI TTGKOY9 DMYZ72J MN Leukotriene CysLT1 receptor (CYSLTR1) DMYZ72J MT DTT DMYZ72J MA Modulator DMYZ72J RN A kinetic binding study to evaluate the pharmacological profile of a specific leukotriene C(4) binding site not coupled to contraction in human lun... Mol Pharmacol. 2000 Jun;57(6):1182-9. DMYZ72J RU https://www.ncbi.nlm.nih.gov/pubmed/10825389 DMYZ72J DI DMYZ72J DMYZ72J DN CGP-57698 DMYZ72J MI TT0PZR5 DMYZ72J MN Leukotriene CysLT2 receptor (CYSLTR2) DMYZ72J MT DTT DMYZ72J MA Modulator DMYZ72J RN A kinetic binding study to evaluate the pharmacological profile of a specific leukotriene C(4) binding site not coupled to contraction in human lun... Mol Pharmacol. 2000 Jun;57(6):1182-9. DMYZ72J RU https://www.ncbi.nlm.nih.gov/pubmed/10825389 DM8KFZH DI DM8KFZH DM8KFZH DN CGP61594 DM8KFZH MI TTLD29N DM8KFZH MN Glutamate receptor ionotropic NMDA 1 (NMDAR1) DM8KFZH MT DTT DM8KFZH MA Antagonist DM8KFZH RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 455). DM8KFZH RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=455 DM8KFZH DI DM8KFZH DM8KFZH DN CGP61594 DM8KFZH MI TTKJEMQ DM8KFZH MN Glutamate receptor ionotropic NMDA 2A (NMDAR2A) DM8KFZH MT DTT DM8KFZH MA Antagonist DM8KFZH RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 456). DM8KFZH RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=456 DM8KFZH DI DM8KFZH DM8KFZH DN CGP61594 DM8KFZH MI TTN9D8E DM8KFZH MN Glutamate receptor ionotropic NMDA 2B (NMDAR2B) DM8KFZH MT DTT DM8KFZH MA Antagonist DM8KFZH RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 457). DM8KFZH RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=457 DM8KFZH DI DM8KFZH DM8KFZH DN CGP61594 DM8KFZH MI TT1M8OW DM8KFZH MN Glutamate receptor ionotropic NMDA 2C (GluN2C) DM8KFZH MT DTT DM8KFZH MA Antagonist DM8KFZH RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 458). DM8KFZH RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=458 DM8KFZH DI DM8KFZH DM8KFZH DN CGP61594 DM8KFZH MI TT5POTG DM8KFZH MN Glutamate receptor ionotropic NMDA 2D (GluN2D) DM8KFZH MT DTT DM8KFZH MA Antagonist DM8KFZH RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 459). DM8KFZH RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=459 DMZ34P1 DI DMZ34P1 DMZ34P1 DN CGP-62464 DMZ34P1 MI TT6PKBN DMZ34P1 MN Proto-oncogene c-Src (SRC) DMZ34P1 MT DTT DMZ34P1 MA Inhibitor DMZ34P1 RN Substituted 5,7-diphenyl-pyrrolo[2,3d]pyrimidines: potent inhibitors of the tyrosine kinase c-Src. Bioorg Med Chem Lett. 2000 May 1;10(9):945-9. DMZ34P1 RU https://pubmed.ncbi.nlm.nih.gov/10853665 DMU5984 DI DMU5984 DMU5984 DN CGP74514A DMU5984 MI TTH6V3D DMU5984 MN Cyclin-dependent kinase 1 (CDK1) DMU5984 MT DTT DMU5984 MA Inhibitor DMU5984 RN 2,6,9-trisubstituted purines: optimization towards highly potent and selective CDK1 inhibitors. Bioorg Med Chem Lett. 1999 Jan 4;9(1):91-6. DMU5984 RU https://pubmed.ncbi.nlm.nih.gov/9990463 DMZ0TGY DI DMZ0TGY DMZ0TGY DN CGS 21680 DMZ0TGY MI TTM2AOE DMZ0TGY MN Adenosine A2a receptor (ADORA2A) DMZ0TGY MT DTT DMZ0TGY MA Agonist DMZ0TGY RN Effects of CGS 21680, a selective adenosine A2A receptor agonist, on allergic airways inflammation in the rat. Eur J Pharmacol. 2002 Mar 8;438(3):183-8. DMZ0TGY RU https://pubmed.ncbi.nlm.nih.gov/11909610 DMZ0TGY DI DMZ0TGY DMZ0TGY DN CGS 21680 DMZ0TGY MI TTNE7KG DMZ0TGY MN Adenosine A2b receptor (ADORA2B) DMZ0TGY MT DTT DMZ0TGY MA Agonist DMZ0TGY RN [3H]CGS 21680, a selective A2 adenosine receptor agonist directly labels A2 receptors in rat brain. J Pharmacol Exp Ther. 1989 Dec;251(3):888-93. DMZ0TGY RU https://pubmed.ncbi.nlm.nih.gov/2600819 DMRU8G7 DI DMRU8G7 DMRU8G7 DN CGS 24012 DMRU8G7 MI TTNE7KG DMRU8G7 MN Adenosine A2b receptor (ADORA2B) DMRU8G7 MT DTT DMRU8G7 MA Agonist DMRU8G7 RN Site-directed mutagenesis identifies residues involved in ligand recognition in the human A2a adenosine receptor. J Biol Chem. 1995 Jun 9;270(23):13987-97. DMRU8G7 RU https://pubmed.ncbi.nlm.nih.gov/7775460 DMCHT27 DI DMCHT27 DMCHT27 DN CGS 35066 DMCHT27 MI TTQ9RYT DMCHT27 MN Endothelin-converting enzyme 1 (ECE1) DMCHT27 MT DTT DMCHT27 MA Inhibitor DMCHT27 RN The therapeutic potential of endothelin-1 receptor antagonists and endothelin-converting enzyme inhibitors on the cardiovascular system. Expert Opin Investig Drugs. 2002 Nov;11(11):1537-52. DMCHT27 RU https://pubmed.ncbi.nlm.nih.gov/12437501 DMCHT27 DI DMCHT27 DMCHT27 DN CGS 35066 DMCHT27 MI TT5U914 DMCHT27 MN Endothelin-converting enzyme 2 (ECE2) DMCHT27 MT DTT DMCHT27 MA Inhibitor DMCHT27 RN The therapeutic potential of endothelin-1 receptor antagonists and endothelin-converting enzyme inhibitors on the cardiovascular system. Expert Opin Investig Drugs. 2002 Nov;11(11):1537-52. DMCHT27 RU https://pubmed.ncbi.nlm.nih.gov/12437501 DM4DSE7 DI DM4DSE7 DM4DSE7 DN CGS-13767 DM4DSE7 MI TT1MPAY DM4DSE7 MN GABA(A) receptor alpha-1 (GABRA1) DM4DSE7 MT DTT DM4DSE7 MA Inhibitor DM4DSE7 RN Synthesis and benzodiazepine binding activity of a series of novel [1,2,4]triazolo[1,5-c]quinazolin-5(6H)-ones. J Med Chem. 1991 Jan;34(1):281-90. DM4DSE7 RU https://pubmed.ncbi.nlm.nih.gov/1846920 DM4DSE7 DI DM4DSE7 DM4DSE7 DN CGS-13767 DM4DSE7 MI TTZA1NY DM4DSE7 MN GABA(A) receptor beta-2 (GABRB2) DM4DSE7 MT DTT DM4DSE7 MA Inhibitor DM4DSE7 RN Synthesis and benzodiazepine binding activity of a series of novel [1,2,4]triazolo[1,5-c]quinazolin-5(6H)-ones. J Med Chem. 1991 Jan;34(1):281-90. DM4DSE7 RU https://pubmed.ncbi.nlm.nih.gov/1846920 DM4DSE7 DI DM4DSE7 DM4DSE7 DN CGS-13767 DM4DSE7 MI TT06RH5 DM4DSE7 MN GABA(A) receptor gamma-2 (GABRG2) DM4DSE7 MT DTT DM4DSE7 MA Inhibitor DM4DSE7 RN Synthesis and benzodiazepine binding activity of a series of novel [1,2,4]triazolo[1,5-c]quinazolin-5(6H)-ones. J Med Chem. 1991 Jan;34(1):281-90. DM4DSE7 RU https://pubmed.ncbi.nlm.nih.gov/1846920 DM4DSE7 DI DM4DSE7 DM4DSE7 DN CGS-13767 DM4DSE7 MI TTNJYV2 DM4DSE7 MN Gamma-aminobutyric acid receptor (GAR) DM4DSE7 MT DTT DM4DSE7 MA Inhibitor DM4DSE7 RN Synthesis and benzodiazepine binding activity of a series of novel [1,2,4]triazolo[1,5-c]quinazolin-5(6H)-ones. J Med Chem. 1991 Jan;34(1):281-90. DM4DSE7 RU https://pubmed.ncbi.nlm.nih.gov/1846920 DM2CS5A DI DM2CS5A DM2CS5A DN CGS-18320B DM2CS5A MI TTSZLWK DM2CS5A MN Aromatase (CYP19A1) DM2CS5A MT DTT DM2CS5A MA Inhibitor DM2CS5A RN Pharmacophore modeling strategies for the development of novel nonsteroidal inhibitors of human aromatase (CYP19). Bioorg Med Chem Lett. 2010 May 15;20(10):3050-64. DM2CS5A RU https://pubmed.ncbi.nlm.nih.gov/20413308 DMDB2KJ DI DMDB2KJ DMDB2KJ DN CGS-19281A DMDB2KJ MI TT3WG5C DMDB2KJ MN Monoamine oxidase type A (MAO-A) DMDB2KJ MT DTT DMDB2KJ MA Inhibitor DMDB2KJ RN Pyrazino[1,2-a]indoles as novel high-affinity and selective imidazoline I(2) receptor ligands. Bioorg Med Chem Lett. 2004 Feb 23;14(4):1003-5. DMDB2KJ RU https://pubmed.ncbi.nlm.nih.gov/15013010 DMDB2KJ DI DMDB2KJ DMDB2KJ DN CGS-19281A DMDB2KJ MI TTGP7BY DMDB2KJ MN Monoamine oxidase type B (MAO-B) DMDB2KJ MT DTT DMDB2KJ MA Inhibitor DMDB2KJ RN Pyrazino[1,2-a]indoles as novel high-affinity and selective imidazoline I(2) receptor ligands. Bioorg Med Chem Lett. 2004 Feb 23;14(4):1003-5. DMDB2KJ RU https://pubmed.ncbi.nlm.nih.gov/15013010 DMC41UH DI DMC41UH DMC41UH DN CGS-19480A DMC41UH MI TTSQIFT DMC41UH MN 5-HT 1A receptor (HTR1A) DMC41UH MT DTT DMC41UH MA Modulator DMC41UH RN WO patent application no. 2012,0025,83, Method for treating schizophrenia and related diseases with a combination therapy. DMC41UH RU http://worldwide.espacenet.com/publicationDetails/biblio?DB=worldwide.espacenet.com&II=0&ND=3&adjacent=true&locale=en_EP&FT=D&date=20120105&CC=WO&NR=2012002583A1&KC=A1 DM5P7TR DI DM5P7TR DM5P7TR DN CGS-23885 DM5P7TR MI TT2J34L DM5P7TR MN Arachidonate 5-lipoxygenase (5-LOX) DM5P7TR MT DTT DM5P7TR MA Modulator DM5P7TR RN Inhibition of LTB4 biosynthesis in situ by CGS 23885, a potent 5-lipoxygenase inhibitor, correlates with its pleural fluid concentrations in an exp... Naunyn Schmiedebergs Arch Pharmacol. 1997 Apr;355(4):470-4. DM5P7TR RU https://www.ncbi.nlm.nih.gov/pubmed/9109363 DM514L0 DI DM514L0 DM514L0 DN CGS-314447 DM514L0 MI TT5TKPM DM514L0 MN Neutral endopeptidase (MME) DM514L0 MT DTT DM514L0 MA Inhibitor DM514L0 RN Potent non-peptidic dual inhibitors of endothelin-converting enzyme and neutral endopeptidase 24.11, Bioorg. Med. Chem. Lett. 7(8):1059-1064 (1997). DM514L0 RU http://www.sciencedirect.com/science/article/pii/S0960894X97001595 DMZKS6Q DI DMZKS6Q DMZKS6Q DN CGS-7181 DMZKS6Q MI TT1VOHK DMZKS6Q MN Potassium channel unspecific (KC) DMZKS6Q MT DTT DMZKS6Q MA Modulator DMZKS6Q RN Molecular mechanism of pharmacological activation of BK channels DMZKS6Q RU https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3295268 DMKY6CU DI DMKY6CU DMKY6CU DN CGS-9895 DMKY6CU MI TT1MPAY DMKY6CU MN GABA(A) receptor alpha-1 (GABRA1) DMKY6CU MT DTT DMKY6CU MA Inhibitor DMKY6CU RN 1,3-Diarylpyrazolo[4,5-c]- and -[5,4-c]quinolin-4-ones. 4. Synthesis and specific inhibition of benzodiazepine receptor binding. J Med Chem. 1987 Oct;30(10):1737-42. DMKY6CU RU https://pubmed.ncbi.nlm.nih.gov/2821257 DMKY6CU DI DMKY6CU DMKY6CU DN CGS-9895 DMKY6CU MI TT06RH5 DMKY6CU MN GABA(A) receptor gamma-2 (GABRG2) DMKY6CU MT DTT DMKY6CU MA Inhibitor DMKY6CU RN 1,3-Diarylpyrazolo[4,5-c]- and -[5,4-c]quinolin-4-ones. 4. Synthesis and specific inhibition of benzodiazepine receptor binding. J Med Chem. 1987 Oct;30(10):1737-42. DMKY6CU RU https://pubmed.ncbi.nlm.nih.gov/2821257 DMKY6CU DI DMKY6CU DMKY6CU DN CGS-9895 DMKY6CU MI TTNJYV2 DMKY6CU MN Gamma-aminobutyric acid receptor (GAR) DMKY6CU MT DTT DMKY6CU MA Inhibitor DMKY6CU RN 1,3-Diarylpyrazolo[4,5-c]- and -[5,4-c]quinolin-4-ones. 4. Synthesis and specific inhibition of benzodiazepine receptor binding. J Med Chem. 1987 Oct;30(10):1737-42. DMKY6CU RU https://pubmed.ncbi.nlm.nih.gov/2821257 DMMJZYC DI DMMJZYC DMMJZYC DN CH-223191 DMMJZYC MI TT037IE DMMJZYC MN Aryl hydrocarbon receptor (AHR) DMMJZYC MT DTT DMMJZYC MA Antagonist DMMJZYC RN Novel compound 2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazo-phenyl)-amide (CH-223191) prevents 2,3,7,8-TCDD-induced toxicity by antagonizing the aryl hydrocarbon receptor. Mol Pharmacol. 2006 Jun;69(6):1871-8. DMMJZYC RU https://pubmed.ncbi.nlm.nih.gov/16540597 DM0RFTJ DI DM0RFTJ DM0RFTJ DN CH-3697 DM0RFTJ MI TTZ97H5 DM0RFTJ MN Phosphodiesterase 4A (PDE4A) DM0RFTJ MT DTT DM0RFTJ MA Inhibitor DM0RFTJ RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1300). DM0RFTJ RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1300 DM0RFTJ DI DM0RFTJ DM0RFTJ DN CH-3697 DM0RFTJ MI TTVIAT9 DM0RFTJ MN Phosphodiesterase 4B (PDE4B) DM0RFTJ MT DTT DM0RFTJ MA Modulator DM0RFTJ RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1301). DM0RFTJ RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1301 DM0RFTJ DI DM0RFTJ DM0RFTJ DN CH-3697 DM0RFTJ MI TTSKMI8 DM0RFTJ MN Phosphodiesterase 4D (PDE4D) DM0RFTJ MT DTT DM0RFTJ MA Modulator DM0RFTJ RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1303). DM0RFTJ RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1303 DMP9UHT DI DMP9UHT DMP9UHT DN CH4474 DMP9UHT MI TT6AZXG DMP9UHT MN TNF alpha converting enzyme (ADAM17) DMP9UHT MT DTT DMP9UHT MA Inhibitor DMP9UHT RN Tumour necrosis factor-alpha converting enzyme (TACE) activity in human colonic epithelial cells. Clin Exp Immunol. 2004 Jan;135(1):146-53. DMP9UHT RU https://pubmed.ncbi.nlm.nih.gov/14678276 DM1ZF3Y DI DM1ZF3Y DM1ZF3Y DN CH-4933468 DM1ZF3Y MI TTS64P2 DM1ZF3Y MN Androgen receptor (AR) DM1ZF3Y MT DTT DM1ZF3Y MA Antagonist DM1ZF3Y RN The ChEMBL database in 2017. Nucleic Acids Res. 2017 Jan 4;45(D1):D945-D954. DM1ZF3Y RU https://www.ncbi.nlm.nih.gov/pubmed/27899562 DMBK86L DI DMBK86L DMBK86L DN chaetocin DMBK86L MI TTUWQTK DMBK86L MN Lysine N-methyltransferase 1A (SUV39H1) DMBK86L MT DTT DMBK86L MA Inhibitor DMBK86L RN Chaetocin is a nonspecific inhibitor of histone lysine methyltransferases. Nat Chem Biol. 2013 Mar;9(3):136-7. DMBK86L RU https://pubmed.ncbi.nlm.nih.gov/23416387 DM16QTM DI DM16QTM DM16QTM DN CHALCONE DM16QTM MI TTGP7BY DM16QTM MN Monoamine oxidase type B (MAO-B) DM16QTM MT DTT DM16QTM MA Inhibitor DM16QTM RN Chalcones: a valid scaffold for monoamine oxidases inhibitors. J Med Chem. 2009 May 14;52(9):2818-24. DM16QTM RU https://pubmed.ncbi.nlm.nih.gov/19378991 DMBZ0QY DI DMBZ0QY DMBZ0QY DN CHAP1 DMBZ0QY MI TTBH0VX DMBZ0QY MN Histone deacetylase (HDAC) DMBZ0QY MT DTT DMBZ0QY MA Inhibitor DMBZ0QY RN Histone deacetylase inhibitors in cancer therapy: latest developments, trends and medicinal chemistry perspective. Anticancer Agents Med Chem. 2007 Sep;7(5):576-92. DMBZ0QY RU https://pubmed.ncbi.nlm.nih.gov/17896917 DMOXRID DI DMOXRID DMOXRID DN CHAP31 DMOXRID MI TTBH0VX DMOXRID MN Histone deacetylase (HDAC) DMOXRID MT DTT DMOXRID MA Inhibitor DMOXRID RN Histone deacetylase inhibitors in cancer therapy: latest developments, trends and medicinal chemistry perspective. Anticancer Agents Med Chem. 2007 Sep;7(5):576-92. DMOXRID RU https://pubmed.ncbi.nlm.nih.gov/17896917 DM0H7AV DI DM0H7AV DM0H7AV DN Chebulagic acid DM0H7AV MI TT2J34L DM0H7AV MN Arachidonate 5-lipoxygenase (5-LOX) DM0H7AV MT DTT DM0H7AV MA Inhibitor DM0H7AV RN Chebulagic acid, a COX-LOX dual inhibitor isolated from the fruits of Terminalia chebula Retz., induces apoptosis in COLO-205 cell line. J Ethnopharmacol. 2009 Jul 30;124(3):506-12. DM0H7AV RU https://pubmed.ncbi.nlm.nih.gov/19481594 DMR8HKC DI DMR8HKC DMR8HKC DN Chebulinic acid DMR8HKC MI TTE14XG DMR8HKC MN Squalene monooxygenase (SQLE) DMR8HKC MT DTT DMR8HKC MA Inhibitor DMR8HKC RN Ellagitannins and hexahydroxydiphenoyl esters as inhibitors of vertebrate squalene epoxidase. J Nat Prod. 2001 Aug;64(8):1010-4. DMR8HKC RU https://pubmed.ncbi.nlm.nih.gov/11520216 DMCP1G9 DI DMCP1G9 DMCP1G9 DN Chelerythrine DMCP1G9 MI TTYVI76 DMCP1G9 MN Fungal Protein kinase A (Fung ypkA) DMCP1G9 MT DTT DMCP1G9 MA Inhibitor DMCP1G9 RN A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases. Proc Natl Acad Sci U S A. 2007 Dec 18;104(51):20523-8. DMCP1G9 RU https://pubmed.ncbi.nlm.nih.gov/18077363 DMCP1G9 DI DMCP1G9 DMCP1G9 DN Chelerythrine DMCP1G9 MI DTFI42L DMCP1G9 MN Multidrug resistance-associated protein 2 (ABCC2) DMCP1G9 MT DTP DMCP1G9 MA Substrate DMCP1G9 RN Human intestinal transporter database: QSAR modeling and virtual profiling of drug uptake, efflux and interactions. Pharm Res. 2013 Apr;30(4):996-1007. DMCP1G9 RU https://doi.org/10.1007/s11095-012-0935-x DMCP1G9 DI DMCP1G9 DMCP1G9 DN Chelerythrine DMCP1G9 MI TT473XN DMCP1G9 MN P2X purinoceptor 7 (P2RX7) DMCP1G9 MT DTT DMCP1G9 MA Modulator (allosteric modulator) DMCP1G9 RN Chelerythrine and other benzophenanthridine alkaloids block the human P2X7 receptor. Br J Pharmacol. 2004 Jul;142(6):1015-9. DMCP1G9 RU https://pubmed.ncbi.nlm.nih.gov/15210579 DMCP1G9 DI DMCP1G9 DMCP1G9 DN Chelerythrine DMCP1G9 MI TT57MT2 DMCP1G9 MN PKC-epsilon messenger RNA (PRKCE mRNA) DMCP1G9 MT DTT DMCP1G9 MA Inhibitor DMCP1G9 RN A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases. Proc Natl Acad Sci U S A. 2007 Dec 18;104(51):20523-8. DMCP1G9 RU https://pubmed.ncbi.nlm.nih.gov/18077363 DMYSG9J DI DMYSG9J DMYSG9J DN Chemosensitizers DMYSG9J MI TT0JLSD DMYSG9J MN Multidrug resistance protein (MDR) DMYSG9J MT DTT DMYSG9J MA Inhibitor DMYSG9J RN P-glycoprotein as a drug target in the treatment of multidrug resistant cancer. Curr Drug Targets. 2000 Jul;1(1):85-99. DMYSG9J RU https://pubmed.ncbi.nlm.nih.gov/11475537 DMLJGVX DI DMLJGVX DMLJGVX DN CHF-2819 DMLJGVX MI TT1RS9F DMLJGVX MN Acetylcholinesterase (AChE) DMLJGVX MT DTT DMLJGVX MA Inhibitor DMLJGVX RN Structural determinants of Torpedo californica acetylcholinesterase inhibition by the novel and orally active carbamate based anti-alzheimer drug g... J Med Chem. 2006 Aug 24;49(17):5051-8. DMLJGVX RU https://pubmed.ncbi.nlm.nih.gov/16913695 DMLJGVX DI DMLJGVX DMLJGVX DN CHF-2819 DMLJGVX MI TTEB0GD DMLJGVX MN Cholinesterase (BCHE) DMLJGVX MT DTT DMLJGVX MA Inhibitor DMLJGVX RN Novel anticholinesterases based on the molecular skeletons of furobenzofuran and methanobenzodioxepine. J Med Chem. 2005 Feb 24;48(4):986-94. DMLJGVX RU https://pubmed.ncbi.nlm.nih.gov/15715468 DM5T64L DI DM5T64L DM5T64L DN CHF-5480 DM5T64L MI TTZ97H5 DM5T64L MN Phosphodiesterase 4A (PDE4A) DM5T64L MT DTT DM5T64L MA Inhibitor DM5T64L RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1300). DM5T64L RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1300 DM5T64L DI DM5T64L DM5T64L DN CHF-5480 DM5T64L MI TTVIAT9 DM5T64L MN Phosphodiesterase 4B (PDE4B) DM5T64L MT DTT DM5T64L MA Inhibitor DM5T64L RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1301). DM5T64L RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1301 DM5T64L DI DM5T64L DM5T64L DN CHF-5480 DM5T64L MI TTSKMI8 DM5T64L MN Phosphodiesterase 4D (PDE4D) DM5T64L MT DTT DM5T64L MA Inhibitor DM5T64L RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1303). DM5T64L RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1303 DMJATBL DI DMJATBL DMJATBL DN Chimeric small nucleolar RNA-TAR decoy DMJATBL MI TTNSXG2 DMJATBL MN Human immunodeficiency virus TAR RNA (HIV TAR-RNA) DMJATBL MT DTT DMJATBL MA Inhibitor DMJATBL RN A nucleolar TAR decoy inhibitor of HIV-1 replication. Proc Natl Acad Sci U S A. 2002 Oct 29;99(22):14047-52. DMJATBL RU https://pubmed.ncbi.nlm.nih.gov/12376617 DMVEBT6 DI DMVEBT6 DMVEBT6 DN CHIR-98014 DMVEBT6 MI TTRSMW9 DMVEBT6 MN Glycogen synthase kinase-3 beta (GSK-3B) DMVEBT6 MT DTT DMVEBT6 MA Inhibitor DMVEBT6 RN Selective glycogen synthase kinase 3 inhibitors potentiate insulin activation of glucose transport and utilization in vitro and in vivo. Diabetes. 2003 Mar;52(3):588-95. DMVEBT6 RU https://pubmed.ncbi.nlm.nih.gov/12606497 DMVEBT6 DI DMVEBT6 DMVEBT6 DN CHIR-98014 DMVEBT6 MI TTQWAU1 DMVEBT6 MN GSK3A messenger RNA (GSK3A mRNA) DMVEBT6 MT DTT DMVEBT6 MA Inhibitor DMVEBT6 RN Selective glycogen synthase kinase 3 inhibitors potentiate insulin activation of glucose transport and utilization in vitro and in vivo. Diabetes. 2003 Mar;52(3):588-95. DMVEBT6 RU https://pubmed.ncbi.nlm.nih.gov/12606497 DMFBW1H DI DMFBW1H DMFBW1H DN CHIR-98023 DMFBW1H MI TTRSMW9 DMFBW1H MN Glycogen synthase kinase-3 beta (GSK-3B) DMFBW1H MT DTT DMFBW1H MA Inhibitor DMFBW1H RN Fragment and knowledge-based design of selective GSK-3beta inhibitors using virtual screening models. Eur J Med Chem. 2009 Jun;44(6):2361-71. DMFBW1H RU https://pubmed.ncbi.nlm.nih.gov/18929433 DMLCZ3D DI DMLCZ3D DMLCZ3D DN Chk1-A DMLCZ3D MI TTTU902 DMLCZ3D MN Checkpoint kinase-1 (CHK1) DMLCZ3D MT DTT DMLCZ3D MA Inhibitor DMLCZ3D RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1987). DMLCZ3D RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1987 DMNSPFG DI DMNSPFG DMNSPFG DN Chk2 inhibitor II DMNSPFG MI TT9ABMF DMNSPFG MN Serine/threonine-protein kinase Chk2 (RAD53) DMNSPFG MT DTT DMNSPFG MA Inhibitor DMNSPFG RN A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases. Proc Natl Acad Sci U S A. 2007 Dec 18;104(51):20523-8. DMNSPFG RU https://pubmed.ncbi.nlm.nih.gov/18077363 DMCHGF1 DI DMCHGF1 DMCHGF1 DN CHLORANIL DMCHGF1 MI TT1RS9F DMCHGF1 MN Acetylcholinesterase (AChE) DMCHGF1 MT DTT DMCHGF1 MA Inhibitor DMCHGF1 RN Identification and characterization of novel benzil (diphenylethane-1,2-dione) analogues as inhibitors of mammalian carboxylesterases. J Med Chem. 2005 Apr 21;48(8):2906-15. DMCHGF1 RU https://pubmed.ncbi.nlm.nih.gov/15828829 DMCHGF1 DI DMCHGF1 DMCHGF1 DN CHLORANIL DMCHGF1 MI TTEB0GD DMCHGF1 MN Cholinesterase (BCHE) DMCHGF1 MT DTT DMCHGF1 MA Inhibitor DMCHGF1 RN Identification and characterization of novel benzil (diphenylethane-1,2-dione) analogues as inhibitors of mammalian carboxylesterases. J Med Chem. 2005 Apr 21;48(8):2906-15. DMCHGF1 RU https://pubmed.ncbi.nlm.nih.gov/15828829 DMCHGF1 DI DMCHGF1 DMCHGF1 DN CHLORANIL DMCHGF1 MI TTMF541 DMCHGF1 MN Liver carboxylesterase (CES1) DMCHGF1 MT DTT DMCHGF1 MA Inhibitor DMCHGF1 RN Identification and characterization of novel benzil (diphenylethane-1,2-dione) analogues as inhibitors of mammalian carboxylesterases. J Med Chem. 2005 Apr 21;48(8):2906-15. DMCHGF1 RU https://pubmed.ncbi.nlm.nih.gov/15828829 DMMHU8G DI DMMHU8G DMMHU8G DN chlordane DMMHU8G MI TTPNQAC DMMHU8G MN Estrogen-related receptor-alpha (ESRRA) DMMHU8G MT DTT DMMHU8G MA Antagonist DMMHU8G RN Two organochlorine pesticides, toxaphene and chlordane, are antagonists for estrogen-related receptor alpha-1 orphan receptor. Cancer Res. 1999 Sep 15;59(18):4519-24. DMMHU8G RU https://pubmed.ncbi.nlm.nih.gov/10493499 DM64K0A DI DM64K0A DM64K0A DN Chlormadinone DM64K0A MI DE4LYSA DM64K0A MN Cytochrome P450 3A4 (CYP3A4) DM64K0A MT DME DM64K0A MA Metabolism DM64K0A RN Drug interactions between rifamycin antibiotics and hormonal contraception: a systematic review. BJOG. 2018 Jun;125(7):804-811. DM64K0A RU https://www.ncbi.nlm.nih.gov/pubmed/?term=29130574 DMY40UB DI DMY40UB DMY40UB DN Chloroben DMY40UB MI DEVDYN7 DMY40UB MN Cytochrome P450 2E1 (CYP2E1) DMY40UB MT DME DMY40UB MA Metabolism DMY40UB RN Cytochrome P450 catalyzed oxidation of monochlorobenzene, 1,2- and 1,4-dichlorobenzene in rat, mouse, and human liver microsomes. Chem Biol Interact. 1998 Aug 14;115(1):53-70. DMY40UB RU https://www.ncbi.nlm.nih.gov/pubmed/?term=9817075 DMLF7MK DI DMLF7MK DMLF7MK DN chlorobenzylidene malononitrile DMLF7MK MI TTELV3W DMLF7MK MN Transformation-sensitive protein p120 (TRPA1) DMLF7MK MT DTT DMLF7MK MA Activator DMLF7MK RN Tear gasses CN, CR, and CS are potent activators of the human TRPA1 receptor. Toxicol Appl Pharmacol. 2008 Sep 1;231(2):150-6. DMLF7MK RU https://pubmed.ncbi.nlm.nih.gov/18501939 DMZA394 DI DMZA394 DMZA394 DN CHLOROCYCLINONE A DMZA394 MI TTT2SVW DMZA394 MN PPAR-gamma messenger RNA (PPARG mRNA) DMZA394 MT DTT DMZA394 MA Inhibitor DMZA394 RN Chlorocyclinones A-D, chlorinated angucyclinones from Streptomyces sp. strongly antagonizing rosiglitazone-induced PPAR-gamma activation. J Nat Prod. 2007 Dec;70(12):1934-8. DMZA394 RU https://pubmed.ncbi.nlm.nih.gov/18044841 DMO78QB DI DMO78QB DMO78QB DN CHLOROCYCLINONE B DMO78QB MI TTT2SVW DMO78QB MN PPAR-gamma messenger RNA (PPARG mRNA) DMO78QB MT DTT DMO78QB MA Inhibitor DMO78QB RN Chlorocyclinones A-D, chlorinated angucyclinones from Streptomyces sp. strongly antagonizing rosiglitazone-induced PPAR-gamma activation. J Nat Prod. 2007 Dec;70(12):1934-8. DMO78QB RU https://pubmed.ncbi.nlm.nih.gov/18044841 DMX2DQ5 DI DMX2DQ5 DMX2DQ5 DN CHLOROCYCLINONE C DMX2DQ5 MI TTT2SVW DMX2DQ5 MN PPAR-gamma messenger RNA (PPARG mRNA) DMX2DQ5 MT DTT DMX2DQ5 MA Inhibitor DMX2DQ5 RN Chlorocyclinones A-D, chlorinated angucyclinones from Streptomyces sp. strongly antagonizing rosiglitazone-induced PPAR-gamma activation. J Nat Prod. 2007 Dec;70(12):1934-8. DMX2DQ5 RU https://pubmed.ncbi.nlm.nih.gov/18044841 DMK7VS1 DI DMK7VS1 DMK7VS1 DN CHLOROCYCLINONE D DMK7VS1 MI TTT2SVW DMK7VS1 MN PPAR-gamma messenger RNA (PPARG mRNA) DMK7VS1 MT DTT DMK7VS1 MA Inhibitor DMK7VS1 RN Chlorocyclinones A-D, chlorinated angucyclinones from Streptomyces sp. strongly antagonizing rosiglitazone-induced PPAR-gamma activation. J Nat Prod. 2007 Dec;70(12):1934-8. DMK7VS1 RU https://pubmed.ncbi.nlm.nih.gov/18044841 DMQT3WJ DI DMQT3WJ DMQT3WJ DN CHLORODEOXYURIDINE DMQT3WJ MI TT5B8AX DMQT3WJ MN Mycobacterium Thymidine monophosphate kinase (MycB tmk) DMQT3WJ MT DTT DMQT3WJ MA Inhibitor DMQT3WJ RN Substituted benzyl-pyrimidines targeting thymidine monophosphate kinase of Mycobacterium tuberculosis: synthesis and in vitro anti-mycobacterial ac... Bioorg Med Chem. 2008 Jun 1;16(11):6075-85. DMQT3WJ RU https://pubmed.ncbi.nlm.nih.gov/18467107 DMGS3FI DI DMGS3FI DMGS3FI DN CHLORODYSINOSIN A DMGS3FI MI TT6L509 DMGS3FI MN Coagulation factor IIa (F2) DMGS3FI MT DTT DMGS3FI MA Inhibitor DMGS3FI RN From natural products to achiral drug prototypes: potent thrombin inhibitors based on P2/P3 dihydropyrid-2-one core motifs. Bioorg Med Chem Lett. 2009 Sep 15;19(18):5429-32. DMGS3FI RU https://pubmed.ncbi.nlm.nih.gov/19674897 DMKZIES DI DMKZIES DMKZIES DN Chloroethylclonidine DMKZIES MI TTWG9A4 DMKZIES MN Adrenergic receptor alpha-2A (ADRA2A) DMKZIES MT DTT DMKZIES MA Agonist DMKZIES RN Selective irreversible binding of chloroethylclonidine at alpha 1- and alpha 2-adrenoceptor subtypes. Mol Pharmacol. 1993 Dec;44(6):1165-70. DMKZIES RU https://pubmed.ncbi.nlm.nih.gov/8264553 DMKZIES DI DMKZIES DMKZIES DN Chloroethylclonidine DMKZIES MI TT2NUT5 DMKZIES MN Adrenergic receptor alpha-2C (ADRA2C) DMKZIES MT DTT DMKZIES MA Agonist DMKZIES RN Selective irreversible binding of chloroethylclonidine at alpha 1- and alpha 2-adrenoceptor subtypes. Mol Pharmacol. 1993 Dec;44(6):1165-70. DMKZIES RU https://pubmed.ncbi.nlm.nih.gov/8264553 DM2Y3P4 DI DM2Y3P4 DM2Y3P4 DN Chlorogenic acid DM2Y3P4 MI TT1KPBZ DM2Y3P4 MN Glucose-6-phosphate translocase (SLC37A4) DM2Y3P4 MT DTT DM2Y3P4 MA Inhibitor DM2Y3P4 RN Chlorogenic acid and synthetic chlorogenic acid derivatives: novel inhibitors of hepatic glucose-6-phosphate translocase. J Med Chem. 1997 Jan 17;40(2):137-45. DM2Y3P4 RU https://pubmed.ncbi.nlm.nih.gov/9003513 DMOA8L2 DI DMOA8L2 DMOA8L2 DN Chlorophenylpiperazine DMOA8L2 MI TTSQIFT DMOA8L2 MN 5-HT 1A receptor (HTR1A) DMOA8L2 MT DTT DMOA8L2 MA Inhibitor DMOA8L2 RN Activity of aromatic substituted phenylpiperazines lacking affinity for dopamine binding sites in a preclinical test of antipsychotic efficacy. J Med Chem. 1989 May;32(5):1052-6. DMOA8L2 RU https://pubmed.ncbi.nlm.nih.gov/2565400 DMOA8L2 DI DMOA8L2 DMOA8L2 DN Chlorophenylpiperazine DMOA8L2 MI TT6MSOK DMOA8L2 MN 5-HT 1D receptor (HTR1D) DMOA8L2 MT DTT DMOA8L2 MA Inhibitor DMOA8L2 RN Activity of aromatic substituted phenylpiperazines lacking affinity for dopamine binding sites in a preclinical test of antipsychotic efficacy. J Med Chem. 1989 May;32(5):1052-6. DMOA8L2 RU https://pubmed.ncbi.nlm.nih.gov/2565400 DMOA8L2 DI DMOA8L2 DMOA8L2 DN Chlorophenylpiperazine DMOA8L2 MI TTJQOD7 DMOA8L2 MN 5-HT 2A receptor (HTR2A) DMOA8L2 MT DTT DMOA8L2 MA Inhibitor DMOA8L2 RN Tricyclic dihydroquinazolinones as novel 5-HT2C selective and orally efficacious anti-obesity agents. Bioorg Med Chem Lett. 2010 Feb 1;20(3):1128-33. DMOA8L2 RU https://pubmed.ncbi.nlm.nih.gov/20022752 DMOA8L2 DI DMOA8L2 DMOA8L2 DN Chlorophenylpiperazine DMOA8L2 MI TT0K1SC DMOA8L2 MN 5-HT 2B receptor (HTR2B) DMOA8L2 MT DTT DMOA8L2 MA Inhibitor DMOA8L2 RN Tricyclic dihydroquinazolinones as novel 5-HT2C selective and orally efficacious anti-obesity agents. Bioorg Med Chem Lett. 2010 Feb 1;20(3):1128-33. DMOA8L2 RU https://pubmed.ncbi.nlm.nih.gov/20022752 DMOA8L2 DI DMOA8L2 DMOA8L2 DN Chlorophenylpiperazine DMOA8L2 MI TTWJBZ5 DMOA8L2 MN 5-HT 2C receptor (HTR2C) DMOA8L2 MT DTT DMOA8L2 MA Inhibitor DMOA8L2 RN Tricyclic dihydroquinazolinones as novel 5-HT2C selective and orally efficacious anti-obesity agents. Bioorg Med Chem Lett. 2010 Feb 1;20(3):1128-33. DMOA8L2 RU https://pubmed.ncbi.nlm.nih.gov/20022752 DMOA8L2 DI DMOA8L2 DMOA8L2 DN Chlorophenylpiperazine DMOA8L2 MI TTJS8PY DMOA8L2 MN 5-HT 6 receptor (HTR6) DMOA8L2 MT DTT DMOA8L2 MA Inhibitor DMOA8L2 RN Higher-end serotonin receptors: 5-HT(5), 5-HT(6), and 5-HT(7). J Med Chem. 2003 Jul 3;46(14):2795-812. DMOA8L2 RU https://pubmed.ncbi.nlm.nih.gov/12825922 DMSGBQA DI DMSGBQA DMSGBQA DN chloropicrin DMSGBQA MI TTELV3W DMSGBQA MN Transformation-sensitive protein p120 (TRPA1) DMSGBQA MT DTT DMSGBQA MA Activator DMSGBQA RN Transient receptor potential ankyrin 1 antagonists block the noxious effects of toxic industrial isocyanates and tear gases. FASEB J. 2009 Apr;23(4):1102-14. DMSGBQA RU https://pubmed.ncbi.nlm.nih.gov/19036859 DM8B0VZ DI DM8B0VZ DM8B0VZ DN CHLOROPUUPEHENONE DM8B0VZ MI TT12ABZ DM8B0VZ MN Arachidonate 12-lipoxygenase (12-LOX) DM8B0VZ MT DTT DM8B0VZ MA Inhibitor DM8B0VZ RN Exploring sponge-derived terpenoids for their potency and selectivity against 12-human, 15-human, and 15-soybean lipoxygenases. J Nat Prod. 2003 Feb;66(2):230-5. DM8B0VZ RU https://pubmed.ncbi.nlm.nih.gov/12608855 DM8B0VZ DI DM8B0VZ DM8B0VZ DN CHLOROPUUPEHENONE DM8B0VZ MI TTN9T81 DM8B0VZ MN Arachidonate 15-lipoxygenase (15-LOX) DM8B0VZ MT DTT DM8B0VZ MA Inhibitor DM8B0VZ RN Exploring sponge-derived terpenoids for their potency and selectivity against 12-human, 15-human, and 15-soybean lipoxygenases. J Nat Prod. 2003 Feb;66(2):230-5. DM8B0VZ RU https://pubmed.ncbi.nlm.nih.gov/12608855 DMM75WZ DI DMM75WZ DMM75WZ DN Chloroxylenol DMM75WZ MI DEJVYAZ DMM75WZ MN Cytochrome P450 2A6 (CYP2A6) DMM75WZ MT DME DMM75WZ MA Metabolism DMM75WZ RN Summary of information on human CYP enzymes: human P450 metabolism data. Drug Metab Rev. 2002 Feb-May;34(1-2):83-448. DMM75WZ RU https://www.ncbi.nlm.nih.gov/pubmed/?term=11996015 DMM75WZ DI DMM75WZ DMM75WZ DN Chloroxylenol DMM75WZ MI DECB0K3 DMM75WZ MN Cytochrome P450 2D6 (CYP2D6) DMM75WZ MT DME DMM75WZ MA Metabolism DMM75WZ RN Summary of information on human CYP enzymes: human P450 metabolism data. Drug Metab Rev. 2002 Feb-May;34(1-2):83-448. DMM75WZ RU https://www.ncbi.nlm.nih.gov/pubmed/?term=11996015 DMM75WZ DI DMM75WZ DMM75WZ DN Chloroxylenol DMM75WZ MI DEVDYN7 DMM75WZ MN Cytochrome P450 2E1 (CYP2E1) DMM75WZ MT DME DMM75WZ MA Metabolism DMM75WZ RN Summary of information on human CYP enzymes: human P450 metabolism data. Drug Metab Rev. 2002 Feb-May;34(1-2):83-448. DMM75WZ RU https://www.ncbi.nlm.nih.gov/pubmed/?term=11996015 DMGBT68 DI DMGBT68 DMGBT68 DN Chlorphrifos oxon DMGBT68 MI TT1RS9F DMGBT68 MN Acetylcholinesterase (AChE) DMGBT68 MT DTT DMGBT68 MA Inhibitor DMGBT68 RN Activation of the endocannabinoid system by organophosphorus nerve agents. Nat Chem Biol. 2008 Jun;4(6):373-8. DMGBT68 RU https://pubmed.ncbi.nlm.nih.gov/18438404 DMGBT68 DI DMGBT68 DMGBT68 DN Chlorphrifos oxon DMGBT68 MI TT6OEDT DMGBT68 MN Cannabinoid receptor 1 (CB1) DMGBT68 MT DTT DMGBT68 MA Inhibitor DMGBT68 RN Monoacylglycerol lipase regulates 2-arachidonoylglycerol action and arachidonic acid levels. Bioorg Med Chem Lett. 2008 Nov 15;18(22):5875-8. DMGBT68 RU https://pubmed.ncbi.nlm.nih.gov/18752948 DMGBT68 DI DMGBT68 DMGBT68 DN Chlorphrifos oxon DMGBT68 MI TTDP1UC DMGBT68 MN Fatty acid amide hydrolase (FAAH) DMGBT68 MT DTT DMGBT68 MA Inhibitor DMGBT68 RN Activation of the endocannabinoid system by organophosphorus nerve agents. Nat Chem Biol. 2008 Jun;4(6):373-8. DMGBT68 RU https://pubmed.ncbi.nlm.nih.gov/18438404 DMKPUI6 DI DMKPUI6 DMKPUI6 DN Chlorpyrifos DMKPUI6 MI TT1RS9F DMKPUI6 MN Acetylcholinesterase (AChE) DMKPUI6 MT DTT DMKPUI6 MA Inhibitor DMKPUI6 RN Synthesis of the novel series of bispyridinium compounds bearing (E)-but-2-ene linker and evaluation of their reactivation activity against chlorpy... Bioorg Med Chem Lett. 2006 Feb;16(3):622-7. DMKPUI6 RU https://pubmed.ncbi.nlm.nih.gov/16288867 DMKPUI6 DI DMKPUI6 DMKPUI6 DN Chlorpyrifos DMKPUI6 MI DEMQRS9 DMKPUI6 MN Cytochrome P450 BM3 (cypBM3) DMKPUI6 MT DME DMKPUI6 MA Metabolism DMKPUI6 RN PEGylation of cytochrome P450 enhances its biocatalytic performance for pesticide transformation. Int J Biol Macromol. 2017 Dec;105(Pt 1):163-170. DMKPUI6 RU https://pubmed.ncbi.nlm.nih.gov/28690168 DMZHO3S DI DMZHO3S DMZHO3S DN CHO793076 DMZHO3S MI TTGTQHC DMZHO3S MN DNA topoisomerase I (TOP1) DMZHO3S MT DTT DMZHO3S MA Inhibitor DMZHO3S RN Synthesis of new camptothecin analogs with improved antitumor activities. Bioorg Med Chem Lett. 2009 Apr 1;19(7):2018-21. DMZHO3S RU https://pubmed.ncbi.nlm.nih.gov/19254843 DMVJMG8 DI DMVJMG8 DMVJMG8 DN Cholecystokinin-9 DMVJMG8 MI TTVFO0U DMVJMG8 MN Gastrin/cholecystokinin type B receptor (CCKBR) DMVJMG8 MT DTT DMVJMG8 MA Inhibitor DMVJMG8 RN 5-(tryptophylamino)-1,3-dioxoperhydropyrido[1,2-c]pyrimidine-based cholecystokinin receptor antagonists: reversal of CCK1 receptor subtype selectiv... J Med Chem. 2004 Oct 7;47(21):5318-29. DMVJMG8 RU https://pubmed.ncbi.nlm.nih.gov/15456276 DMKM3WJ DI DMKM3WJ DMKM3WJ DN cholesten DMKM3WJ MI TTS4UGC DMKM3WJ MN Farnesoid X-activated receptor (FXR) DMKM3WJ MT DTT DMKM3WJ MA Agonist DMKM3WJ RN Identification of farnesoid X receptor beta as a novel mammalian nuclear receptor sensing lanosterol. Mol Cell Biol. 2003 Feb;23(3):864-72. DMKM3WJ RU https://pubmed.ncbi.nlm.nih.gov/12529392 DMR3J6S DI DMR3J6S DMR3J6S DN Cholesterol DMR3J6S MI DT61TWI DMR3J6S MN ATP-binding cassette sub-family A member 1 (ABCA1) DMR3J6S MT DTP DMR3J6S MA Substrate DMR3J6S RN ABCA1 redistributes membrane cholesterol independent of apolipoprotein interactions. J Lipid Res. 2003 Jul;44(7):1373-80. DMR3J6S RU http://www.ncbi.nlm.nih.gov/pubmed/12700343 DMR3J6S DI DMR3J6S DMR3J6S DN Cholesterol DMR3J6S MI DT7LDG0 DMR3J6S MN ATP-binding cassette sub-family A member 12 (ABCA12) DMR3J6S MT DTP DMR3J6S MA Substrate DMR3J6S RN ABCA12 regulates ABCA1-dependent cholesterol efflux from macrophages and the development of atherosclerosis. Cell Metab. 2013 Aug 6;18(2):225-38. DMR3J6S RU http://www.ncbi.nlm.nih.gov/pubmed/23931754 DMR3J6S DI DMR3J6S DMR3J6S DN Cholesterol DMR3J6S MI DTJ4NEG DMR3J6S MN ATP-binding cassette sub-family A member 2 (ABCA2) DMR3J6S MT DTP DMR3J6S MA Substrate DMR3J6S RN The ATP-binding cassette transporter-2 (ABCA2) regulates cholesterol homeostasis and low-density lipoprotein receptor metabolism in N2a neuroblastoma cells. Biochim Biophys Acta. 2011 Dec;1811(12):1152-64. DMR3J6S RU http://www.ncbi.nlm.nih.gov/pubmed/21810484 DMR3J6S DI DMR3J6S DMR3J6S DN Cholesterol DMR3J6S MI DT195NK DMR3J6S MN ATP-binding cassette sub-family A member 5 (ABCA5) DMR3J6S MT DTP DMR3J6S MA Substrate DMR3J6S RN Mutations in the cholesterol transporter gene ABCA5 are associated with excessive hair overgrowth. PLoS Genet. 2014 May 15;10(5):e1004333. DMR3J6S RU http://www.ncbi.nlm.nih.gov/pubmed/24831815 DMR3J6S DI DMR3J6S DMR3J6S DN Cholesterol DMR3J6S MI DTLYEPH DMR3J6S MN ATP-binding cassette sub-family G member 1 (ABCG1) DMR3J6S MT DTP DMR3J6S MA Substrate DMR3J6S RN Role of HDL, ABCA1, and ABCG1 transporters in cholesterol efflux and immune responses. Arterioscler Thromb Vasc Biol. 2010 Feb;30(2):139-43. DMR3J6S RU http://www.ncbi.nlm.nih.gov/pubmed/19797709 DMR3J6S DI DMR3J6S DMR3J6S DN Cholesterol DMR3J6S MI DTI7UX6 DMR3J6S MN Breast cancer resistance protein (ABCG2) DMR3J6S MT DTP DMR3J6S MA Substrate DMR3J6S RN Sterol transport by the human breast cancer resistance protein (ABCG2) expressed in Lactococcus lactis. J Biol Chem. 2003 Jun 6;278(23):20645-51. DMR3J6S RU http://www.ncbi.nlm.nih.gov/pubmed/12668685 DMR3J6S DI DMR3J6S DMR3J6S DN Cholesterol DMR3J6S MI TTUAIKM DMR3J6S MN Cholinephosphate cytidylyltransferase (PCYT1B) DMR3J6S MT DTT DMR3J6S MA Activator DMR3J6S RN Regulation of CTP: phosphocholine cytidylyltransferase activity by the physical properties of lipid membranes: an important role for stored curvature strain energy. Biochemistry. 2001 Sep 4;40(35):10522-31. DMR3J6S RU https://pubmed.ncbi.nlm.nih.gov/11523994 DMR3J6S DI DMR3J6S DMR3J6S DN Cholesterol DMR3J6S MI DT1UMXN DMR3J6S MN Niemann-Pick C1-like protein 1 (SLC65A2) DMR3J6S MT DTP DMR3J6S MA Substrate DMR3J6S RN Niemann-Pick C1 Like 1 protein is critical for intestinal cholesterol absorption. Science. 2004 Feb 20;303(5661):1201-4. DMR3J6S RU http://www.ncbi.nlm.nih.gov/pubmed/14976318 DMR3J6S DI DMR3J6S DMR3J6S DN Cholesterol DMR3J6S MI DTUGYRD DMR3J6S MN P-glycoprotein 1 (ABCB1) DMR3J6S MT DTP DMR3J6S MA Substrate DMR3J6S RN Cholesterol interaction with the daunorubicin binding site of P-glycoprotein. Biochem Biophys Res Commun. 2000 Oct 5;276(3):909-16. DMR3J6S RU https://doi.org/10.1006/bbrc.2000.3554 DM5D9YK DI DM5D9YK DM5D9YK DN Choline DM5D9YK MI DEAHED0 DM5D9YK MN Choline dehydrogenase (CHDH) DM5D9YK MT DME DM5D9YK MA Metabolism DM5D9YK RN Usual choline and betaine dietary intake and incident coronary heart disease: the atherosclerosis risk in communities (ARIC) study. BMC Cardiovasc Disord. 2007 Jul 13;7:20. DM5D9YK RU https://www.ncbi.nlm.nih.gov/pubmed/?term=17629908 DM5D9YK DI DM5D9YK DM5D9YK DN Choline DM5D9YK MI DEMRAYN DM5D9YK MN Choline kinase alpha (CHKA) DM5D9YK MT DME DM5D9YK MA Metabolism DM5D9YK RN Crystal structures of human choline kinase isoforms in complex with hemicholinium-3: single amino acid near the active site influences inhibitor sensitivity. J Biol Chem. 2010 May 21;285(21):16330-40. DM5D9YK RU https://www.ncbi.nlm.nih.gov/pubmed/?term=20299452 DM5D9YK DI DM5D9YK DM5D9YK DN Choline DM5D9YK MI DE5NGOW DM5D9YK MN Choline O-acetyltransferase (CHAT) DM5D9YK MT DME DM5D9YK MA Metabolism DM5D9YK RN The effect of trichlorfon and methylazoxymethanol on the development of guinea pig cerebellum. Toxicol Appl Pharmacol. 2007 Mar;219(2-3):128-35. DM5D9YK RU https://www.ncbi.nlm.nih.gov/pubmed/?term=17150236 DM5D9YK DI DM5D9YK DM5D9YK DN Choline DM5D9YK MI DT3I2SU DM5D9YK MN Choline transporter-like protein 1 (SLC44A1) DM5D9YK MT DTP DM5D9YK MA Substrate DM5D9YK RN Decreased biosynthesis of lung surfactant constituent phosphatidylcholine due to inhibition of choline transporter by gefitinib in lung alveolar cells. Pharm Res. 2008 Feb;25(2):417-27. DM5D9YK RU http://www.ncbi.nlm.nih.gov/pubmed/17624579 DM5D9YK DI DM5D9YK DM5D9YK DN Choline DM5D9YK MI DTSF91X DM5D9YK MN Choline transporter-like protein 2 (SLC44A2) DM5D9YK MT DTP DM5D9YK MA Substrate DM5D9YK RN The choline transporter-like family SLC44: properties and roles in human diseases. Mol Aspects Med. 2013 Apr-Jun;34(2-3):646-54. DM5D9YK RU http://www.ncbi.nlm.nih.gov/pubmed/23506897 DM5D9YK DI DM5D9YK DM5D9YK DN Choline DM5D9YK MI DT8KXR9 DM5D9YK MN Choline transporter-like protein 4 (SLC44A4) DM5D9YK MT DTP DM5D9YK MA Substrate DM5D9YK RN SLC44A4 mutation causes autosomal dominant hereditary postlingual non-syndromic mid-frequency hearing loss. Hum Mol Genet. 2017 Jan 15;26(2):383-394. DM5D9YK RU http://www.ncbi.nlm.nih.gov/pubmed/28013291 DM5D9YK DI DM5D9YK DM5D9YK DN Choline DM5D9YK MI DTU8NCX DM5D9YK MN Choline transporter-like protein 5 (SLC44A5) DM5D9YK MT DTP DM5D9YK MA Substrate DM5D9YK RN The molecular effects of a polymorphism in the 5'UTR of solute carrier family 44, member 5 that is associated with birth weight in Holsteins. PLoS One. 2012;7(7):e41267. DM5D9YK RU http://www.ncbi.nlm.nih.gov/pubmed/22815983 DM5D9YK DI DM5D9YK DM5D9YK DN Choline DM5D9YK MI DEHWR6V DM5D9YK MN Choline/ethanolamine kinase (CHKB) DM5D9YK MT DME DM5D9YK MA Metabolism DM5D9YK RN Crystal structures of human choline kinase isoforms in complex with hemicholinium-3: single amino acid near the active site influences inhibitor sensitivity. J Biol Chem. 2010 May 21;285(21):16330-40. DM5D9YK RU https://www.ncbi.nlm.nih.gov/pubmed/?term=20299452 DM5D9YK DI DM5D9YK DM5D9YK DN Choline DM5D9YK MI DEL87ZT DM5D9YK MN Choline/ethanolaminephosphotransferase 1 (CEPT1) DM5D9YK MT DME DM5D9YK MA Metabolism DM5D9YK RN PC and PE synthesis: mixed micellar analysis of the cholinephosphotransferase and ethanolaminephosphotransferase activities of human choline/ethanolamine phosphotransferase 1 (CEPT1). Lipids. 2002 Jul;37(7):663-72. DM5D9YK RU https://www.ncbi.nlm.nih.gov/pubmed/?term=12216837 DM5D9YK DI DM5D9YK DM5D9YK DN Choline DM5D9YK MI DTBPTJF DM5D9YK MN Na(+)/Cl(-) betaine/GABA transporter (SLC6A12) DM5D9YK MT DTP DM5D9YK MA Substrate DM5D9YK RN Interpreting metabolomic profiles using unbiased pathway models. PLoS Comput Biol. 2010 Feb 26;6(2):e1000692. DM5D9YK RU http://www.ncbi.nlm.nih.gov/pubmed/20195502 DM5D9YK DI DM5D9YK DM5D9YK DN Choline DM5D9YK MI TTF4E0J DM5D9YK MN Neuronal acetylcholine receptor alpha-2 (CHRNA2) DM5D9YK MT DTT DM5D9YK MA Inhibitor DM5D9YK RN Pharmacology of the agonist binding sites of rat neuronal nicotinic receptor subtypes expressed in HEK 293 cells. Bioorg Med Chem Lett. 2004 Apr 19;14(8):1845-8. DM5D9YK RU https://pubmed.ncbi.nlm.nih.gov/15050613 DM5D9YK DI DM5D9YK DM5D9YK DN Choline DM5D9YK MI DTT79CX DM5D9YK MN Organic cation transporter 1 (SLC22A1) DM5D9YK MT DTP DM5D9YK MA Substrate DM5D9YK RN Human intestinal transporter database: QSAR modeling and virtual profiling of drug uptake, efflux and interactions. Pharm Res. 2013 Apr;30(4):996-1007. DM5D9YK RU https://doi.org/10.1007/s11095-012-0935-x DM5D9YK DI DM5D9YK DM5D9YK DN Choline DM5D9YK MI DT9IDPW DM5D9YK MN Organic cation transporter 2 (SLC22A2) DM5D9YK MT DTP DM5D9YK MA Substrate DM5D9YK RN Ventricular choline transport: a role for organic cation transporter 2 expressed in choroid plexus. J Biol Chem. 2001 Nov 9;276(45):41611-9. DM5D9YK RU http://www.ncbi.nlm.nih.gov/pubmed/11553644 DMW6U7K DI DMW6U7K DMW6U7K DN CHOLINE IODIDE DMW6U7K MI TT1RS9F DMW6U7K MN Acetylcholinesterase (AChE) DMW6U7K MT DTT DMW6U7K MA Inhibitor DMW6U7K RN Structure-based alignment and comparative molecular field analysis of acetylcholinesterase inhibitors. J Med Chem. 1996 Dec 20;39(26):5064-71. DMW6U7K RU https://pubmed.ncbi.nlm.nih.gov/8978837 DMVBQ20 DI DMVBQ20 DMVBQ20 DN Cholini alfosceras DMVBQ20 MI DEUL532 DMVBQ20 MN Choline glycerophosphodiester phosphodiesterase (ENPP6) DMVBQ20 MT DME DMVBQ20 MA Metabolism DMVBQ20 RN Biochemical and molecular characterization of a novel choline-specific glycerophosphodiester phosphodiesterase belonging to the nucleotide pyrophosphatase/phosphodiesterase family. J Biol Chem. 2005 Jun 17;280(24):23084-93. DMVBQ20 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=15788404 DMZ956E DI DMZ956E DMZ956E DN CHPG DMZ956E MI TTHS256 DMZ956E MN Metabotropic glutamate receptor 5 (mGluR5) DMZ956E MT DTT DMZ956E MA Agonist DMZ956E RN Characterization of [(3)H]Quisqualate binding to recombinant rat metabotropic glutamate 1a and 5a receptors and to rat and human brain sections. J Neurochem. 2000 Dec;75(6):2590-601. DMZ956E RU https://pubmed.ncbi.nlm.nih.gov/11080213 DMXKU73 DI DMXKU73 DMXKU73 DN CHR-4125 DMXKU73 MI TTIYVQP DMXKU73 MN Polo-like kinase 1 (PLK1) DMXKU73 MT DTT DMXKU73 MA Inhibitor DMXKU73 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2168). DMXKU73 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2168 DMVDB7S DI DMVDB7S DMVDB7S DN chroman 28 DMVDB7S MI TTGY8IW DMVDB7S MN B2 bradykinin receptor (BDKRB2) DMVDB7S MT DTT DMVDB7S MA Antagonist DMVDB7S RN Identification of a nonpeptidic and conformationally restricted bradykinin B1 receptor antagonist with anti-inflammatory activity. J Med Chem. 2007 Feb 22;50(4):607-10. DMVDB7S RU https://pubmed.ncbi.nlm.nih.gov/17243660 DM5JHUN DI DM5JHUN DM5JHUN DN CHROMOTROPATE DM5JHUN MI TTELIN2 DM5JHUN MN PTPN1 messenger RNA (PTPN1 mRNA) DM5JHUN MT DTT DM5JHUN MA Inhibitor DM5JHUN RN Evans Blue and other dyes as protein tyrosine phosphatase inhibitors. Bioorg Med Chem Lett. 2004 Apr 19;14(8):1923-6. DM5JHUN RU https://pubmed.ncbi.nlm.nih.gov/15050628 DMLEXN0 DI DMLEXN0 DMLEXN0 DN Chrysamine -G DMLEXN0 MI TTE4KHA DMLEXN0 MN Amyloid beta A4 protein (APP) DMLEXN0 MT DTT DMLEXN0 MA Inhibitor DMLEXN0 RN Curcumin and dehydrozingerone derivatives: synthesis, radiolabeling, and evaluation for beta-amyloid plaque imaging. J Med Chem. 2006 Oct 5;49(20):6111-9. DMLEXN0 RU https://pubmed.ncbi.nlm.nih.gov/17004725 DM7V2LG DI DM7V2LG DM7V2LG DN Chrysin DM7V2LG MI TTFBNVI DM7V2LG MN Aldose reductase (AKR1B1) DM7V2LG MT DTT DM7V2LG MA Inhibitor DM7V2LG RN Synthesis, characterization and vasculoprotective effects of nitric oxide-donating derivatives of chrysin. Bioorg Med Chem. 2010 May 1;18(9):3020-5. DM7V2LG RU https://pubmed.ncbi.nlm.nih.gov/20395149 DM7V2LG DI DM7V2LG DM7V2LG DN Chrysin DM7V2LG MI TTSZLWK DM7V2LG MN Aromatase (CYP19A1) DM7V2LG MT DTT DM7V2LG MA Inhibitor DM7V2LG RN Pharmacophore modeling strategies for the development of novel nonsteroidal inhibitors of human aromatase (CYP19). Bioorg Med Chem Lett. 2010 May 15;20(10):3050-64. DM7V2LG RU https://pubmed.ncbi.nlm.nih.gov/20413308 DM7V2LG DI DM7V2LG DM7V2LG DN Chrysin DM7V2LG MI DTI7UX6 DM7V2LG MN Breast cancer resistance protein (ABCG2) DM7V2LG MT DTP DM7V2LG MA Substrate DM7V2LG RN Mammalian drug efflux transporters of the ATP binding cassette (ABC) family in multidrug resistance: A review of the past decade. Cancer Lett. 2016 Jan 1;370(1):153-64. DM7V2LG RU http://www.ncbi.nlm.nih.gov/pubmed/26499806 DM7V2LG DI DM7V2LG DM7V2LG DN Chrysin DM7V2LG MI TTO0FDJ DM7V2LG MN Cyclin-dependent kinase 6 (CDK6) DM7V2LG MT DTT DM7V2LG MA Inhibitor DM7V2LG RN Crystal structure of a human cyclin-dependent kinase 6 complex with a flavonol inhibitor, fisetin. J Med Chem. 2005 Feb 10;48(3):737-43. DM7V2LG RU https://pubmed.ncbi.nlm.nih.gov/15689157 DM7V2LG DI DM7V2LG DM7V2LG DN Chrysin DM7V2LG MI TTI84H7 DM7V2LG MN Cytochrome P450 1B1 (CYP1B1) DM7V2LG MT DTT DM7V2LG MA Inhibitor DM7V2LG RN Selective inhibition of methoxyflavonoids on human CYP1B1 activity. Bioorg Med Chem. 2010 Sep 1;18(17):6310-5. DM7V2LG RU https://pubmed.ncbi.nlm.nih.gov/20696580 DM7V2LG DI DM7V2LG DM7V2LG DN Chrysin DM7V2LG MI TTBE4IR DM7V2LG MN Plasmodium Oxoacyl-[acyl-carrier protein] reductase (Malaria fabG) DM7V2LG MT DTT DM7V2LG MA Inhibitor DM7V2LG RN Inhibition of Plasmodium falciparum fatty acid biosynthesis: evaluation of FabG, FabZ, and FabI as drug targets for flavonoids. J Med Chem. 2006 Jun 1;49(11):3345-53. DM7V2LG RU https://pubmed.ncbi.nlm.nih.gov/16722653 DM7V2LG DI DM7V2LG DM7V2LG DN Chrysin DM7V2LG MI DEYGVN4 DM7V2LG MN UDP-glucuronosyltransferase 1A1 (UGT1A1) DM7V2LG MT DME DM7V2LG MA Metabolism DM7V2LG RN Differential and special properties of the major human UGT1-encoded gastrointestinal UDP-glucuronosyltransferases enhance potential to control chemical uptake. J Biol Chem. 2004 Jan 9;279(2):1429-41. DM7V2LG RU https://www.ncbi.nlm.nih.gov/pubmed/?term=14557274 DM7V2LG DI DM7V2LG DM7V2LG DN Chrysin DM7V2LG MI DEZO4N3 DM7V2LG MN UDP-glucuronosyltransferase 1A7 (UGT1A7) DM7V2LG MT DME DM7V2LG MA Metabolism DM7V2LG RN Differential and special properties of the major human UGT1-encoded gastrointestinal UDP-glucuronosyltransferases enhance potential to control chemical uptake. J Biol Chem. 2004 Jan 9;279(2):1429-41. DM7V2LG RU https://www.ncbi.nlm.nih.gov/pubmed/?term=14557274 DM7V2LG DI DM7V2LG DM7V2LG DN Chrysin DM7V2LG MI DE2GB8N DM7V2LG MN UDP-glucuronosyltransferase 1A8 (UGT1A8) DM7V2LG MT DME DM7V2LG MA Metabolism DM7V2LG RN Differential and special properties of the major human UGT1-encoded gastrointestinal UDP-glucuronosyltransferases enhance potential to control chemical uptake. J Biol Chem. 2004 Jan 9;279(2):1429-41. DM7V2LG RU https://www.ncbi.nlm.nih.gov/pubmed/?term=14557274 DM7V2LG DI DM7V2LG DM7V2LG DN Chrysin DM7V2LG MI DE85D2P DM7V2LG MN UDP-glucuronosyltransferase 1A9 (UGT1A9) DM7V2LG MT DME DM7V2LG MA Metabolism DM7V2LG RN Differential and special properties of the major human UGT1-encoded gastrointestinal UDP-glucuronosyltransferases enhance potential to control chemical uptake. J Biol Chem. 2004 Jan 9;279(2):1429-41. DM7V2LG RU https://www.ncbi.nlm.nih.gov/pubmed/?term=14557274 DM96ECL DI DM96ECL DM96ECL DN CHRYSOERIOL DM96ECL MI TTI84H7 DM96ECL MN Cytochrome P450 1B1 (CYP1B1) DM96ECL MT DTT DM96ECL MA Inhibitor DM96ECL RN Selective inhibition of methoxyflavonoids on human CYP1B1 activity. Bioorg Med Chem. 2010 Sep 1;18(17):6310-5. DM96ECL RU https://pubmed.ncbi.nlm.nih.gov/20696580 DM96ECL DI DM96ECL DM96ECL DN CHRYSOERIOL DM96ECL MI TT7RJY8 DM96ECL MN Xanthine dehydrogenase/oxidase (XDH) DM96ECL MT DTT DM96ECL MA Inhibitor DM96ECL RN Inhibition of cow's milk xanthine oxidase by flavonoids. J Nat Prod. 1988 Mar-Apr;51(2):345-8. DM96ECL RU https://pubmed.ncbi.nlm.nih.gov/3379415 DMT27QD DI DMT27QD DMT27QD DN CHYMOSTATIN DMT27QD MI TT8VUE0 DMT27QD MN Chymase (CYM) DMT27QD MT DTT DMT27QD MA Inhibitor DMT27QD RN Identification of 6-substituted 4-arylsulfonyl-1,4-diazepane-2,5-diones as a novel scaffold for human chymase inhibitors. Bioorg Med Chem Lett. 2007 Jun 15;17(12):3431-4. DMT27QD RU https://pubmed.ncbi.nlm.nih.gov/17419055 DMQ5CE1 DI DMQ5CE1 DMQ5CE1 DN CI-1015 DMQ5CE1 MI TTCG0AL DMQ5CE1 MN Cholecystokinin receptor type A (CCKAR) DMQ5CE1 MT DTT DMQ5CE1 MA Antagonist DMQ5CE1 RN Second generation "peptoid" CCK-B receptor antagonists: identification and development of N-(adamantyloxycarbonyl)-alpha-methyl-(R)-tryptophan derivative (CI-1015) with an improved pharmacokinetic profile. J Med Chem. 1998 Jan 1;41(1):38-45. DMQ5CE1 RU https://pubmed.ncbi.nlm.nih.gov/9438020 DMQ5CE1 DI DMQ5CE1 DMQ5CE1 DN CI-1015 DMQ5CE1 MI TTVFO0U DMQ5CE1 MN Gastrin/cholecystokinin type B receptor (CCKBR) DMQ5CE1 MT DTT DMQ5CE1 MA Antagonist DMQ5CE1 RN Second generation "peptoid" CCK-B receptor antagonists: identification and development of N-(adamantyloxycarbonyl)-alpha-methyl-(R)-tryptophan derivative (CI-1015) with an improved pharmacokinetic profile. J Med Chem. 1998 Jan 1;41(1):38-45. DMQ5CE1 RU https://pubmed.ncbi.nlm.nih.gov/9438020 DMTKVDZ DI DMTKVDZ DMTKVDZ DN CI-1031 DMTKVDZ MI TTCIHJA DMTKVDZ MN Coagulation factor Xa (F10) DMTKVDZ MT DTT DMTKVDZ MA Modulator DMTKVDZ RN Effects of ZK-807834, a novel inhibitor of factor Xa, on arterial and venous thrombosis in rabbits. J Cardiovasc Pharmacol. 2000 May;35(5):796-805. DMTKVDZ RU https://www.ncbi.nlm.nih.gov/pubmed/10813384 DMF3DZX DI DMF3DZX DMF3DZX DN CI-1040 DMF3DZX MI TTTU902 DMF3DZX MN Checkpoint kinase-1 (CHK1) DMF3DZX MT DTT DMF3DZX MA Inhibitor DMF3DZX RN Specificity and mechanism of action of some commonly used protein kinase inhibitors. Biochem J. 2000 Oct 1;351(Pt 1):95-105. DMF3DZX RU https://pubmed.ncbi.nlm.nih.gov/10998351 DMF3DZX DI DMF3DZX DMF3DZX DN CI-1040 DMF3DZX MI TT4TQBX DMF3DZX MN Extracellular signal-regulated kinase 2 (ERK2) DMF3DZX MT DTT DMF3DZX MA Inhibitor DMF3DZX RN Specificity and mechanism of action of some commonly used protein kinase inhibitors. Biochem J. 2000 Oct 1;351(Pt 1):95-105. DMF3DZX RU https://pubmed.ncbi.nlm.nih.gov/10998351 DMF3DZX DI DMF3DZX DMF3DZX DN CI-1040 DMF3DZX MI TTRSMW9 DMF3DZX MN Glycogen synthase kinase-3 beta (GSK-3B) DMF3DZX MT DTT DMF3DZX MA Inhibitor DMF3DZX RN Specificity and mechanism of action of some commonly used protein kinase inhibitors. Biochem J. 2000 Oct 1;351(Pt 1):95-105. DMF3DZX RU https://pubmed.ncbi.nlm.nih.gov/10998351 DMF3DZX DI DMF3DZX DMF3DZX DN CI-1040 DMF3DZX MI TT860QF DMF3DZX MN LCK tyrosine protein kinase (LCK) DMF3DZX MT DTT DMF3DZX MA Inhibitor DMF3DZX RN Specificity and mechanism of action of some commonly used protein kinase inhibitors. Biochem J. 2000 Oct 1;351(Pt 1):95-105. DMF3DZX RU https://pubmed.ncbi.nlm.nih.gov/10998351 DMF3DZX DI DMF3DZX DMF3DZX DN CI-1040 DMF3DZX MI TTYT93M DMF3DZX MN MAP kinase p38 (MAPK12) DMF3DZX MT DTT DMF3DZX MA Inhibitor DMF3DZX RN Specificity and mechanism of action of some commonly used protein kinase inhibitors. Biochem J. 2000 Oct 1;351(Pt 1):95-105. DMF3DZX RU https://pubmed.ncbi.nlm.nih.gov/10998351 DMF3DZX DI DMF3DZX DMF3DZX DN CI-1040 DMF3DZX MI TTQBCEJ DMF3DZX MN MAPK/ERK kinase kinase 1 (MAP3K1) DMF3DZX MT DTT DMF3DZX MA Inhibitor DMF3DZX RN Pharmacological inhibitors of MAPK pathways. Trends Pharmacol Sci. 2002 Jan;23(1):40-5. DMF3DZX RU https://pubmed.ncbi.nlm.nih.gov/11804650 DMF3DZX DI DMF3DZX DMF3DZX DN CI-1040 DMF3DZX MI TTK1N5G DMF3DZX MN MAPK/ERK kinase kinase 2 (MAP3K2) DMF3DZX MT DTT DMF3DZX MA Inhibitor DMF3DZX RN Pharmacological inhibitors of MAPK pathways. Trends Pharmacol Sci. 2002 Jan;23(1):40-5. DMF3DZX RU https://pubmed.ncbi.nlm.nih.gov/11804650 DMF3DZX DI DMF3DZX DMF3DZX DN CI-1040 DMF3DZX MI TTFJ8Q1 DMF3DZX MN Protein kinase C alpha (PRKCA) DMF3DZX MT DTT DMF3DZX MA Inhibitor DMF3DZX RN Specificity and mechanism of action of some commonly used protein kinase inhibitors. Biochem J. 2000 Oct 1;351(Pt 1):95-105. DMF3DZX RU https://pubmed.ncbi.nlm.nih.gov/10998351 DMF3DZX DI DMF3DZX DMF3DZX DN CI-1040 DMF3DZX MI TTWTSCV DMF3DZX MN RAC-alpha serine/threonine-protein kinase (AKT1) DMF3DZX MT DTT DMF3DZX MA Inhibitor DMF3DZX RN Specificity and mechanism of action of some commonly used protein kinase inhibitors. Biochem J. 2000 Oct 1;351(Pt 1):95-105. DMF3DZX RU https://pubmed.ncbi.nlm.nih.gov/10998351 DMF3DZX DI DMF3DZX DMF3DZX DN CI-1040 DMF3DZX MI TTZN7RP DMF3DZX MN Rho-associated protein kinase 1 (ROCK1) DMF3DZX MT DTT DMF3DZX MA Inhibitor DMF3DZX RN Specificity and mechanism of action of some commonly used protein kinase inhibitors. Biochem J. 2000 Oct 1;351(Pt 1):95-105. DMF3DZX RU https://pubmed.ncbi.nlm.nih.gov/10998351 DMF3DZX DI DMF3DZX DMF3DZX DN CI-1040 DMF3DZX MI TTG0U4H DMF3DZX MN Ribosomal protein S6 kinase beta-1 (S6K1) DMF3DZX MT DTT DMF3DZX MA Inhibitor DMF3DZX RN Specificity and mechanism of action of some commonly used protein kinase inhibitors. Biochem J. 2000 Oct 1;351(Pt 1):95-105. DMF3DZX RU https://pubmed.ncbi.nlm.nih.gov/10998351 DMF3DZX DI DMF3DZX DMF3DZX DN CI-1040 DMF3DZX MI TTTV8EJ DMF3DZX MN Serine/threonine-protein kinase Sgk1 (SGK1) DMF3DZX MT DTT DMF3DZX MA Inhibitor DMF3DZX RN Specificity and mechanism of action of some commonly used protein kinase inhibitors. Biochem J. 2000 Oct 1;351(Pt 1):95-105. DMF3DZX RU https://pubmed.ncbi.nlm.nih.gov/10998351 DMF3DZX DI DMF3DZX DMF3DZX DN CI-1040 DMF3DZX MI TTQBR95 DMF3DZX MN Stress-activated protein kinase 2a (p38 alpha) DMF3DZX MT DTT DMF3DZX MA Inhibitor DMF3DZX RN Specificity and mechanism of action of some commonly used protein kinase inhibitors. Biochem J. 2000 Oct 1;351(Pt 1):95-105. DMF3DZX RU https://pubmed.ncbi.nlm.nih.gov/10998351 DMF3DZX DI DMF3DZX DMF3DZX DN CI-1040 DMF3DZX MI TT73U6C DMF3DZX MN Stress-activated protein kinase 2b (p38 beta) DMF3DZX MT DTT DMF3DZX MA Inhibitor DMF3DZX RN Specificity and mechanism of action of some commonly used protein kinase inhibitors. Biochem J. 2000 Oct 1;351(Pt 1):95-105. DMF3DZX RU https://pubmed.ncbi.nlm.nih.gov/10998351 DMF3DZX DI DMF3DZX DMF3DZX DN CI-1040 DMF3DZX MI TT0K6EO DMF3DZX MN Stress-activated protein kinase JNK1 (JNK1) DMF3DZX MT DTT DMF3DZX MA Inhibitor DMF3DZX RN Specificity and mechanism of action of some commonly used protein kinase inhibitors. Biochem J. 2000 Oct 1;351(Pt 1):95-105. DMF3DZX RU https://pubmed.ncbi.nlm.nih.gov/10998351 DMG5D6B DI DMG5D6B DMG5D6B DN CI-1044 DMG5D6B MI TTZ97H5 DMG5D6B MN Phosphodiesterase 4A (PDE4A) DMG5D6B MT DTT DMG5D6B MA Inhibitor DMG5D6B RN Synthesis, structure-activity relationships, and pharmacological profile of 9-amino-4-oxo-1-phenyl-3,4,6,7-tetrahydro[1,4]diazepino[6, 7,1-hi]indol... J Med Chem. 2000 Dec 14;43(25):4850-67. DMG5D6B RU https://pubmed.ncbi.nlm.nih.gov/11123995 DMG5D6B DI DMG5D6B DMG5D6B DN CI-1044 DMG5D6B MI TTVIAT9 DMG5D6B MN Phosphodiesterase 4B (PDE4B) DMG5D6B MT DTT DMG5D6B MA Inhibitor DMG5D6B RN Synthesis, structure-activity relationships, and pharmacological profile of 9-amino-4-oxo-1-phenyl-3,4,6,7-tetrahydro[1,4]diazepino[6, 7,1-hi]indol... J Med Chem. 2000 Dec 14;43(25):4850-67. DMG5D6B RU https://pubmed.ncbi.nlm.nih.gov/11123995 DM0RH3S DI DM0RH3S DM0RH3S DN CI-218872 DM0RH3S MI TT1MPAY DM0RH3S MN GABA(A) receptor alpha-1 (GABRA1) DM0RH3S MT DTT DM0RH3S MA Inhibitor DM0RH3S RN Four amino acid exchanges convert a diazepam-insensitive, inverse agonist-preferring GABAA receptor into a diazepam-preferring GABAA receptor. J Med Chem. 1994 Dec 23;37(26):4576-80. DM0RH3S RU https://pubmed.ncbi.nlm.nih.gov/7799410 DM0RH3S DI DM0RH3S DM0RH3S DN CI-218872 DM0RH3S MI TTBMV1G DM0RH3S MN GABA(A) receptor alpha-2 (GABRA2) DM0RH3S MT DTT DM0RH3S MA Inhibitor DM0RH3S RN Design, synthesis, and subtype selectivity of 3,6-disubstituted -carbolines at Bz/GABA(A)ergic receptors. SAR and studies directed toward agents f... Bioorg Med Chem. 2010 Nov 1;18(21):7548-64. DM0RH3S RU https://pubmed.ncbi.nlm.nih.gov/20888240 DM0RH3S DI DM0RH3S DM0RH3S DN CI-218872 DM0RH3S MI TT37EDJ DM0RH3S MN GABA(A) receptor alpha-3 (GABRA3) DM0RH3S MT DTT DM0RH3S MA Inhibitor DM0RH3S RN Design, synthesis, and subtype selectivity of 3,6-disubstituted -carbolines at Bz/GABA(A)ergic receptors. SAR and studies directed toward agents f... Bioorg Med Chem. 2010 Nov 1;18(21):7548-64. DM0RH3S RU https://pubmed.ncbi.nlm.nih.gov/20888240 DM0RH3S DI DM0RH3S DM0RH3S DN CI-218872 DM0RH3S MI TTNZPQ1 DM0RH3S MN GABA(A) receptor alpha-5 (GABRA5) DM0RH3S MT DTT DM0RH3S MA Inhibitor DM0RH3S RN Design, synthesis, and subtype selectivity of 3,6-disubstituted -carbolines at Bz/GABA(A)ergic receptors. SAR and studies directed toward agents f... Bioorg Med Chem. 2010 Nov 1;18(21):7548-64. DM0RH3S RU https://pubmed.ncbi.nlm.nih.gov/20888240 DM0RH3S DI DM0RH3S DM0RH3S DN CI-218872 DM0RH3S MI TTZA1NY DM0RH3S MN GABA(A) receptor beta-2 (GABRB2) DM0RH3S MT DTT DM0RH3S MA Inhibitor DM0RH3S RN Four amino acid exchanges convert a diazepam-insensitive, inverse agonist-preferring GABAA receptor into a diazepam-preferring GABAA receptor. J Med Chem. 1994 Dec 23;37(26):4576-80. DM0RH3S RU https://pubmed.ncbi.nlm.nih.gov/7799410 DM0RH3S DI DM0RH3S DM0RH3S DN CI-218872 DM0RH3S MI TT06RH5 DM0RH3S MN GABA(A) receptor gamma-2 (GABRG2) DM0RH3S MT DTT DM0RH3S MA Inhibitor DM0RH3S RN Four amino acid exchanges convert a diazepam-insensitive, inverse agonist-preferring GABAA receptor into a diazepam-preferring GABAA receptor. J Med Chem. 1994 Dec 23;37(26):4576-80. DM0RH3S RU https://pubmed.ncbi.nlm.nih.gov/7799410 DM0RH3S DI DM0RH3S DM0RH3S DN CI-218872 DM0RH3S MI TTNJYV2 DM0RH3S MN Gamma-aminobutyric acid receptor (GAR) DM0RH3S MT DTT DM0RH3S MA Inhibitor DM0RH3S RN Design, synthesis, and subtype selectivity of 3,6-disubstituted -carbolines at Bz/GABA(A)ergic receptors. SAR and studies directed toward agents f... Bioorg Med Chem. 2010 Nov 1;18(21):7548-64. DM0RH3S RU https://pubmed.ncbi.nlm.nih.gov/20888240 DMWE1N8 DI DMWE1N8 DMWE1N8 DN Cibacron blue DMWE1N8 MI TTCYE56 DMWE1N8 MN Glutathione-dependent PGD synthase (HPGDS) DMWE1N8 MT DTT DMWE1N8 MA Inhibitor DMWE1N8 RN A novel method for screening the glutathione transferase inhibitors. BMC Biochem. 2009 Mar 16;10:6. DMWE1N8 RU https://pubmed.ncbi.nlm.nih.gov/19291299 DM7ZJ4H DI DM7ZJ4H DM7ZJ4H DN cicaprost DM7ZJ4H MI TTOFYT1 DM7ZJ4H MN Prostacyclin receptor (PTGIR) DM7ZJ4H MT DTT DM7ZJ4H MA Agonist DM7ZJ4H RN Ligand binding specificities of the eight types and subtypes of the mouse prostanoid receptors expressed in Chinese hamster ovary cells. Br J Pharmacol. 1997 Sep;122(2):217-24. DM7ZJ4H RU https://pubmed.ncbi.nlm.nih.gov/9313928 DM7ZJ4H DI DM7ZJ4H DM7ZJ4H DN cicaprost DM7ZJ4H MI TTG1QMU DM7ZJ4H MN Prostaglandin E2 receptor EP1 (PTGER1) DM7ZJ4H MT DTT DM7ZJ4H MA Agonist DM7ZJ4H RN The utilization of recombinant prostanoid receptors to determine the affinities and selectivities of prostaglandins and related analogs. Biochim Biophys Acta. 2000 Jan 17;1483(2):285-93. DM7ZJ4H RU https://pubmed.ncbi.nlm.nih.gov/10634944 DM7ZJ4H DI DM7ZJ4H DM7ZJ4H DN cicaprost DM7ZJ4H MI TT1ZAVI DM7ZJ4H MN Prostaglandin E2 receptor EP2 (PTGER2) DM7ZJ4H MT DTT DM7ZJ4H MA Agonist DM7ZJ4H RN Ligand binding specificities of the eight types and subtypes of the mouse prostanoid receptors expressed in Chinese hamster ovary cells. Br J Pharmacol. 1997 Sep;122(2):217-24. DM7ZJ4H RU https://pubmed.ncbi.nlm.nih.gov/9313928 DM7ZJ4H DI DM7ZJ4H DM7ZJ4H DN cicaprost DM7ZJ4H MI TTPNGDE DM7ZJ4H MN Prostaglandin E2 receptor EP3 (PTGER3) DM7ZJ4H MT DTT DM7ZJ4H MA Agonist DM7ZJ4H RN Ligand binding specificities of the eight types and subtypes of the mouse prostanoid receptors expressed in Chinese hamster ovary cells. Br J Pharmacol. 1997 Sep;122(2):217-24. DM7ZJ4H RU https://pubmed.ncbi.nlm.nih.gov/9313928 DM7ZJ4H DI DM7ZJ4H DM7ZJ4H DN cicaprost DM7ZJ4H MI TT79WV3 DM7ZJ4H MN Prostaglandin E2 receptor EP4 (PTGER4) DM7ZJ4H MT DTT DM7ZJ4H MA Agonist DM7ZJ4H RN The utilization of recombinant prostanoid receptors to determine the affinities and selectivities of prostaglandins and related analogs. Biochim Biophys Acta. 2000 Jan 17;1483(2):285-93. DM7ZJ4H RU https://pubmed.ncbi.nlm.nih.gov/10634944 DM27S6E DI DM27S6E DM27S6E DN cicloprolol DM27S6E MI TTMXGCW DM27S6E MN Adrenergic receptor beta-3 (ADRB3) DM27S6E MT DTT DM27S6E MA Antagonist DM27S6E RN LK 204-545, a highly selective beta1-adrenoceptor antagonist at human beta-adrenoceptors. Eur J Pharmacol. 1999 Feb 19;367(2-3):431-5. DM27S6E RU https://pubmed.ncbi.nlm.nih.gov/10079020 DMP6BU3 DI DMP6BU3 DMP6BU3 DN Ciclosporin DMP6BU3 MI TT95SAZ DMP6BU3 MN HUMAN cyclophilin D (CYP3) DMP6BU3 MT DTT DMP6BU3 MA Inhibitor DMP6BU3 RN Therapeutic options for the 2019 novel coronavirus (2019-nCoV). Nat Rev Drug Discov. 2020 Mar;19(3):149-150. DMP6BU3 RU https://pubmed.ncbi.nlm.nih.gov/32127666 DMK6YOP DI DMK6YOP DMK6YOP DN CID1172084 DMK6YOP MI TTNET8J DMK6YOP MN G-protein coupled receptor 55 (GPR55) DMK6YOP MT DTT DMK6YOP MA Agonist DMK6YOP RN Identification of the GPR55 agonist binding site using a novel set of high-potency GPR55 selective ligands. Biochemistry. 2011 Jun 28;50(25):5633-47. DMK6YOP RU https://pubmed.ncbi.nlm.nih.gov/21534610 DMLWZRT DI DMLWZRT DMLWZRT DN CID16020046 DMLWZRT MI TTNET8J DMLWZRT MN G-protein coupled receptor 55 (GPR55) DMLWZRT MT DTT DMLWZRT MA Antagonist DMLWZRT RN A selective antagonist reveals a potential role of G protein-coupled receptor 55 in platelet and endothelial cell function. J Pharmacol Exp Ther. 2013 Jul;346(1):54-66. DMLWZRT RU https://pubmed.ncbi.nlm.nih.gov/23639801 DMP6I98 DI DMP6I98 DMP6I98 DN CID16197121 DMP6I98 MI TT2AP5B DMP6I98 MN Ras converting CAAX endopeptidase 1 (RCE1) DMP6I98 MT DTT DMP6I98 MA Inhibitor DMP6I98 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2412). DMP6I98 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2412 DMEGZY7 DI DMEGZY7 DMEGZY7 DN CID1792197 DMEGZY7 MI TTNET8J DMEGZY7 MN G-protein coupled receptor 55 (GPR55) DMEGZY7 MT DTT DMEGZY7 MA Agonist DMEGZY7 RN Identification of the GPR55 agonist binding site using a novel set of high-potency GPR55 selective ligands. Biochemistry. 2011 Jun 28;50(25):5633-47. DMEGZY7 RU https://pubmed.ncbi.nlm.nih.gov/21534610 DMA3F7S DI DMA3F7S DMA3F7S DN CID2440433 DMA3F7S MI TTNET8J DMA3F7S MN G-protein coupled receptor 55 (GPR55) DMA3F7S MT DTT DMA3F7S MA Agonist DMA3F7S RN Identification of the GPR55 agonist binding site using a novel set of high-potency GPR55 selective ligands. Biochemistry. 2011 Jun 28;50(25):5633-47. DMA3F7S RU https://pubmed.ncbi.nlm.nih.gov/21534610 DMSHIQA DI DMSHIQA DMSHIQA DN CID755673 DMSHIQA MI TTSLUMT DMSHIQA MN Protein kinase D (PRKD1) DMSHIQA MT DTT DMSHIQA MA Inhibitor DMSHIQA RN Protein kinase D as a potential new target for cancer therapy. Biochim Biophys Acta. 2010 Dec;1806(2):183-92. DMSHIQA RU https://pubmed.ncbi.nlm.nih.gov/20580776 DMP35OM DI DMP35OM DMP35OM DN CIFEA DMP35OM MI TT0WAIE DMP35OM MN Melatonin receptor type 1A (MTNR1A) DMP35OM MT DTT DMP35OM MA Agonist DMP35OM RN 1,6-Dihydro-2H-indeno[5,4-b]furan derivatives: design, synthesis, and pharmacological characterization of a novel class of highly potent MT selective agonists. J Med Chem. 2011 May 12;54(9):3436-44. DMP35OM RU https://pubmed.ncbi.nlm.nih.gov/21473625 DMBVIKY DI DMBVIKY DMBVIKY DN Cilostamide DMBVIKY MI TTZCG4L DMBVIKY MN Phosphodiesterase 3 (PDE3) DMBVIKY MT DTT DMBVIKY MA Inhibitor DMBVIKY RN Phosphodiesterase 3 as a potential target for therapy of malignant tumors in the submandibular gland. Anticancer Drugs. 2001 Jan;12(1):79-83. DMBVIKY RU https://pubmed.ncbi.nlm.nih.gov/11272291 DM6TJFU DI DM6TJFU DM6TJFU DN CINANSERIN DM6TJFU MI TTJQOD7 DM6TJFU MN 5-HT 2A receptor (HTR2A) DM6TJFU MT DTT DM6TJFU MA Inhibitor DM6TJFU RN Central serotonin receptors as targets for drug research. J Med Chem. 1987 Jan;30(1):1-12. DM6TJFU RU https://pubmed.ncbi.nlm.nih.gov/3543362 DMOJ917 DI DMOJ917 DMOJ917 DN Cinchoninic acid DMOJ917 MI TT3PQ2Y DMOJ917 MN Plasmodium Dihydroorotate dehydrogenase (Malaria DHOdehase) DMOJ917 MT DTT DMOJ917 MA Inhibitor DMOJ917 RN Kinetics of inhibition of human and rat dihydroorotate dehydrogenase by atovaquone, lawsone derivatives, brequinar sodium and polyporic acid. Chem Biol Interact. 2000 Jan 3;124(1):61-76. DMOJ917 RU https://pubmed.ncbi.nlm.nih.gov/10658902 DMZDUXG DI DMZDUXG DMZDUXG DN cinnamaldehyde DMZDUXG MI TTELV3W DMZDUXG MN Transformation-sensitive protein p120 (TRPA1) DMZDUXG MT DTT DMZDUXG MA Activator DMZDUXG RN Noxious cold ion channel TRPA1 is activated by pungent compounds and bradykinin. Neuron. 2004 Mar 25;41(6):849-57. DMZDUXG RU https://pubmed.ncbi.nlm.nih.gov/15046718 DMZDUXG DI DMZDUXG DMZDUXG DN cinnamaldehyde DMZDUXG MI TT946IA DMZDUXG MN Transient receptor potential cation channel V3 (TRPV3) DMZDUXG MT DTT DMZDUXG MA Activator DMZDUXG RN More than cool: promiscuous relationships of menthol and other sensory compounds. Mol Cell Neurosci. 2006 Aug;32(4):335-43. DMZDUXG RU https://pubmed.ncbi.nlm.nih.gov/16829128 DM340FH DI DM340FH DM340FH DN Cinnamic acid DM340FH MI TTWNV8U DM340FH MN Nicotinic acid receptor (HCAR2) DM340FH MT DTT DM340FH MA Agonist DM340FH RN Phenolic acids suppress adipocyte lipolysis via activation of the nicotinic acid receptor GPR109A (HM74a/PUMA-G). J Lipid Res. 2009 May;50(5):908-14. DM340FH RU https://pubmed.ncbi.nlm.nih.gov/19136666 DM340FH DI DM340FH DM340FH DN Cinnamic acid DM340FH MI TTXMI0C DM340FH MN Phosphomevalonate kinase (PMVK) DM340FH MT DTT DM340FH MA Inhibitor DM340FH RN Inhibition of rat liver mevalonate pyrophosphate decarboxylase and mevalonate phosphate kinase by phenyl and phenolic compounds. Biochem J. 1979 Jul 1;181(1):143-51. DM340FH RU https://pubmed.ncbi.nlm.nih.gov/226078 DMZ2WS9 DI DMZ2WS9 DMZ2WS9 DN CIP-137401 DMZ2WS9 MI TTROQ37 DMZ2WS9 MN MAPK/ERK kinase kinase (MAP3K) DMZ2WS9 MT DTT DMZ2WS9 MA Inhibitor DMZ2WS9 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2063). DMZ2WS9 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2063 DM9N8WM DI DM9N8WM DM9N8WM DN Ciproxifan DM9N8WM MI TTNXLKE DM9N8WM MN 5-HT 3 receptor (5HT3R) DM9N8WM MT DTT DM9N8WM MA Antagonist DM9N8WM RN The histamine H3 receptor: from gene cloning to H3 receptor drugs. Nat Rev Drug Discov. 2005 Feb;4(2):107-20. DM9N8WM RU https://pubmed.ncbi.nlm.nih.gov/15665857 DM9N8WM DI DM9N8WM DM9N8WM DN Ciproxifan DM9N8WM MI TTWG9A4 DM9N8WM MN Adrenergic receptor alpha-2A (ADRA2A) DM9N8WM MT DTT DM9N8WM MA Antagonist DM9N8WM RN The histamine H3 receptor: from gene cloning to H3 receptor drugs. Nat Rev Drug Discov. 2005 Feb;4(2):107-20. DM9N8WM RU https://pubmed.ncbi.nlm.nih.gov/15665857 DM9N8WM DI DM9N8WM DM9N8WM DN Ciproxifan DM9N8WM MI TT2NUT5 DM9N8WM MN Adrenergic receptor alpha-2C (ADRA2C) DM9N8WM MT DTT DM9N8WM MA Antagonist DM9N8WM RN The histamine H3 receptor: from gene cloning to H3 receptor drugs. Nat Rev Drug Discov. 2005 Feb;4(2):107-20. DM9N8WM RU https://pubmed.ncbi.nlm.nih.gov/15665857 DM9N8WM DI DM9N8WM DM9N8WM DN Ciproxifan DM9N8WM MI TT9JNIC DM9N8WM MN Histamine H3 receptor (H3R) DM9N8WM MT DTT DM9N8WM MA Antagonist DM9N8WM RN The histamine H3 receptor: from gene cloning to H3 receptor drugs. Nat Rev Drug Discov. 2005 Feb;4(2):107-20. DM9N8WM RU https://pubmed.ncbi.nlm.nih.gov/15665857 DMU6JOK DI DMU6JOK DMU6JOK DN cirazoline DMU6JOK MI TT2NUT5 DMU6JOK MN Adrenergic receptor alpha-2C (ADRA2C) DMU6JOK MT DTT DMU6JOK MA Agonist DMU6JOK RN Selectivity of agonists for cloned alpha 1-adrenergic receptor subtypes. Mol Pharmacol. 1994 Nov;46(5):929-36. DMU6JOK RU https://pubmed.ncbi.nlm.nih.gov/7969082 DMM10TG DI DMM10TG DMM10TG DN Cirsimarin DMM10TG MI TTK25J1 DMM10TG MN Adenosine A1 receptor (ADORA1) DMM10TG MT DTT DMM10TG MA Inhibitor DMM10TG RN Adenosine-1 active ligands: cirsimarin, a flavone glycoside from Microtea debilis. J Nat Prod. 1997 Jun;60(6):638-41. DMM10TG RU https://pubmed.ncbi.nlm.nih.gov/9214739 DMA3N9R DI DMA3N9R DMA3N9R DN CIRSIMARITIN DMA3N9R MI TTJFY5U DMA3N9R MN Adenosine A3 receptor (ADORA3) DMA3N9R MT DTT DMA3N9R MA Inhibitor DMA3N9R RN Interactions of flavonoids and other phytochemicals with adenosine receptors. J Med Chem. 1996 Feb 2;39(3):781-8. DMA3N9R RU https://pubmed.ncbi.nlm.nih.gov/8576921 DMWX6J0 DI DMWX6J0 DMWX6J0 DN Cis-(+/-)-2-Fluoro-1,2-diphenylcyclopropylamine DMWX6J0 MI TT3WG5C DMWX6J0 MN Monoamine oxidase type A (MAO-A) DMWX6J0 MT DTT DMWX6J0 MA Inhibitor DMWX6J0 RN Fluorinated phenylcyclopropylamines. Part 5: Effects of electron-withdrawing or -donating aryl substituents on the inhibition of monoamine oxidases... Bioorg Med Chem. 2008 Aug 1;16(15):7148-66. DMWX6J0 RU https://pubmed.ncbi.nlm.nih.gov/18640844 DMV3RYK DI DMV3RYK DMV3RYK DN Cis-[PtCl(NH3)2(N7-acyclovir)]+ DMV3RYK MI TTJP4SM DMV3RYK MN Bacterial Penicillin binding protein (Bact PBP) DMV3RYK MT DTT DMV3RYK RN DNA interactions of a novel platinum drug, cis-[PtCl(NH3)2(N7-acyclovir)]+. Mol Pharmacol. 1998 May;53(5):846-55. DMV3RYK RU https://pubmed.ncbi.nlm.nih.gov/9584210 DMP3F0D DI DMP3F0D DMP3F0D DN Cis-1-adamantan-1-yl-3-(4-hydroxycyclohexyl)urea DMP3F0D MI TT7WVHI DMP3F0D MN Soluble epoxide hydrolase (EPHX2) DMP3F0D MT DTT DMP3F0D MA Inhibitor DMP3F0D RN Orally bioavailable potent soluble epoxide hydrolase inhibitors. J Med Chem. 2007 Aug 9;50(16):3825-40. DMP3F0D RU https://pubmed.ncbi.nlm.nih.gov/17616115 DM8NX3Q DI DM8NX3Q DM8NX3Q DN Cis-1-adamantan-1-yl-3-(4-methoxycyclohexyl)urea DM8NX3Q MI TT7WVHI DM8NX3Q MN Soluble epoxide hydrolase (EPHX2) DM8NX3Q MT DTT DM8NX3Q MA Inhibitor DM8NX3Q RN Orally bioavailable potent soluble epoxide hydrolase inhibitors. J Med Chem. 2007 Aug 9;50(16):3825-40. DM8NX3Q RU https://pubmed.ncbi.nlm.nih.gov/17616115 DMVRF9H DI DMVRF9H DMVRF9H DN Cis-2-(4-chlorophenyl)-2-fluorocyclopropanamine DMVRF9H MI TTGP7BY DMVRF9H MN Monoamine oxidase type B (MAO-B) DMVRF9H MT DTT DMVRF9H MA Inhibitor DMVRF9H RN Fluorinated phenylcyclopropylamines. Part 5: Effects of electron-withdrawing or -donating aryl substituents on the inhibition of monoamine oxidases... Bioorg Med Chem. 2008 Aug 1;16(15):7148-66. DMVRF9H RU https://pubmed.ncbi.nlm.nih.gov/18640844 DMPZ1LY DI DMPZ1LY DMPZ1LY DN Cis-2-(para-fluorophenyl)cyclopropylamine DMPZ1LY MI TTGP7BY DMPZ1LY MN Monoamine oxidase type B (MAO-B) DMPZ1LY MT DTT DMPZ1LY MA Inhibitor DMPZ1LY RN Fluorinated phenylcyclopropylamines. Part 5: Effects of electron-withdrawing or -donating aryl substituents on the inhibition of monoamine oxidases... Bioorg Med Chem. 2008 Aug 1;16(15):7148-66. DMPZ1LY RU https://pubmed.ncbi.nlm.nih.gov/18640844 DMJ3HG9 DI DMJ3HG9 DMJ3HG9 DN Cis-2,6-dimethyl-1-methyl sulfonyl piperidine DMJ3HG9 MI TT1RS9F DMJ3HG9 MN Acetylcholinesterase (AChE) DMJ3HG9 MT DTT DMJ3HG9 MA Inhibitor DMJ3HG9 RN Active site directed docking studies: synthesis and pharmacological evaluation of cis-2,6-dimethyl piperidine sulfonamides as inhibitors of acetylc... Eur J Med Chem. 2009 Oct;44(10):4057-62. DMJ3HG9 RU https://pubmed.ncbi.nlm.nih.gov/19493592 DMF10WT DI DMF10WT DMF10WT DN Cis-2-aminocyclohexylcarbamoylphosphonic acid DMF10WT MI TTLM12X DMF10WT MN Matrix metalloproteinase-2 (MMP-2) DMF10WT MT DTT DMF10WT MA Inhibitor DMF10WT RN Carbamoylphosphonate matrix metalloproteinase inhibitors 6: cis-2-aminocyclohexylcarbamoylphosphonic acid, a novel orally active antimetastatic mat... J Med Chem. 2008 Mar 13;51(5):1406-14. DMF10WT RU https://pubmed.ncbi.nlm.nih.gov/18257543 DMNG9B2 DI DMNG9B2 DMNG9B2 DN Cis-2-Fluoro-2-(4-methoxyphenyl)cyclopropylamine DMNG9B2 MI TTGP7BY DMNG9B2 MN Monoamine oxidase type B (MAO-B) DMNG9B2 MT DTT DMNG9B2 MA Inhibitor DMNG9B2 RN Fluorinated phenylcyclopropylamines. Part 5: Effects of electron-withdrawing or -donating aryl substituents on the inhibition of monoamine oxidases... Bioorg Med Chem. 2008 Aug 1;16(15):7148-66. DMNG9B2 RU https://pubmed.ncbi.nlm.nih.gov/18640844 DMFSPHE DI DMFSPHE DMFSPHE DN Cis-2-fluoro-2-phenylcyclopropanamine DMFSPHE MI TTGP7BY DMFSPHE MN Monoamine oxidase type B (MAO-B) DMFSPHE MT DTT DMFSPHE MA Inhibitor DMFSPHE RN Fluorinated phenylcyclopropylamines. Part 5: Effects of electron-withdrawing or -donating aryl substituents on the inhibition of monoamine oxidases... Bioorg Med Chem. 2008 Aug 1;16(15):7148-66. DMFSPHE RU https://pubmed.ncbi.nlm.nih.gov/18640844 DMKZ32J DI DMKZ32J DMKZ32J DN Cis-2-phenylcyclopropylamine DMKZ32J MI TT3WG5C DMKZ32J MN Monoamine oxidase type A (MAO-A) DMKZ32J MT DTT DMKZ32J MA Inhibitor DMKZ32J RN Fluorinated phenylcyclopropylamines. Part 5: Effects of electron-withdrawing or -donating aryl substituents on the inhibition of monoamine oxidases... Bioorg Med Chem. 2008 Aug 1;16(15):7148-66. DMKZ32J RU https://pubmed.ncbi.nlm.nih.gov/18640844 DMKZ32J DI DMKZ32J DMKZ32J DN Cis-2-phenylcyclopropylamine DMKZ32J MI TTGP7BY DMKZ32J MN Monoamine oxidase type B (MAO-B) DMKZ32J MT DTT DMKZ32J MA Inhibitor DMKZ32J RN Fluorinated phenylcyclopropylamines. Part 5: Effects of electron-withdrawing or -donating aryl substituents on the inhibition of monoamine oxidases... Bioorg Med Chem. 2008 Aug 1;16(15):7148-66. DMKZ32J RU https://pubmed.ncbi.nlm.nih.gov/18640844 DMQ0EA7 DI DMQ0EA7 DMQ0EA7 DN cis-3-ACPBPA DMQ0EA7 MI TT6XFEU DMQ0EA7 MN GABA(A) receptor rho1 (GABRR1) DMQ0EA7 MT DTT DMQ0EA7 MA Antagonist DMQ0EA7 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 420). DMQ0EA7 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=420 DMQ0EA7 DI DMQ0EA7 DMQ0EA7 DN cis-3-ACPBPA DMQ0EA7 MI TTQMXLS DMQ0EA7 MN GABA(A) receptor rho2 (GABRR2) DMQ0EA7 MT DTT DMQ0EA7 MA Antagonist DMQ0EA7 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 421). DMQ0EA7 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=421 DMQ0EA7 DI DMQ0EA7 DMQ0EA7 DN cis-3-ACPBPA DMQ0EA7 MI TT4N6D8 DMQ0EA7 MN GABA(A) receptor rho3 (GABRR3) DMQ0EA7 MT DTT DMQ0EA7 MA Antagonist DMQ0EA7 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 422). DMQ0EA7 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=422 DMTH4BG DI DMTH4BG DMTH4BG DN Cis-3-phenoxy-2,3-dihydro-1H-inden-1-amine DMTH4BG MI TTVBI8W DMTH4BG MN Dopamine transporter (DAT) DMTH4BG MT DTT DMTH4BG MA Inhibitor DMTH4BG RN Discovery of a potent, selective, and less flexible selective norepinephrine reuptake inhibitor (sNRI). Bioorg Med Chem Lett. 2008 Jul 15;18(14):4224-7. DMTH4BG RU https://pubmed.ncbi.nlm.nih.gov/18550369 DMTH4BG DI DMTH4BG DMTH4BG DN Cis-3-phenoxy-2,3-dihydro-1H-inden-1-amine DMTH4BG MI TTAWNKZ DMTH4BG MN Norepinephrine transporter (NET) DMTH4BG MT DTT DMTH4BG MA Inhibitor DMTH4BG RN Discovery of a potent, selective, and less flexible selective norepinephrine reuptake inhibitor (sNRI). Bioorg Med Chem Lett. 2008 Jul 15;18(14):4224-7. DMTH4BG RU https://pubmed.ncbi.nlm.nih.gov/18550369 DMX07BG DI DMX07BG DMX07BG DN Cis-4-hydroxynipecotic acid DMX07BG MI TTV9MQG DMX07BG MN Gamma-aminobutyric acid uptake (GABAU) DMX07BG MT DTT DMX07BG MA Inhibitor DMX07BG RN GABA uptake inhibitors. Synthesis and effects on audiogenic seizures of ester prodrugs of nipecotic acid, guvacine and cis-4-hydroxynipecotic acid. Drug Des Deliv. 1987 Sep;2(1):9-21. DMX07BG RU https://pubmed.ncbi.nlm.nih.gov/3509345 DMRFTB5 DI DMRFTB5 DMRFTB5 DN Cis-4-hydroxytamoxifen DMRFTB5 MI DEYGVN4 DMRFTB5 MN UDP-glucuronosyltransferase 1A1 (UGT1A1) DMRFTB5 MT DME DMRFTB5 MA Metabolism DMRFTB5 RN Glucuronidation of active tamoxifen metabolites by the human UDP glucuronosyltransferases. Drug Metab Dispos. 2007 Nov;35(11):2006-14. DMRFTB5 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=17664247 DMRFTB5 DI DMRFTB5 DMRFTB5 DN Cis-4-hydroxytamoxifen DMRFTB5 MI DE2GB8N DMRFTB5 MN UDP-glucuronosyltransferase 1A8 (UGT1A8) DMRFTB5 MT DME DMRFTB5 MA Metabolism DMRFTB5 RN Glucuronidation of active tamoxifen metabolites by the human UDP glucuronosyltransferases. Drug Metab Dispos. 2007 Nov;35(11):2006-14. DMRFTB5 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=17664247 DMQUB19 DI DMQUB19 DMQUB19 DN Cis-H-Tyr-c[D-AllylGly-Gly-Phe-D-Allylgly]-OH DMQUB19 MI TT27RFC DMQUB19 MN Opioid receptor delta (OPRD1) DMQUB19 MT DTT DMQUB19 MA Inhibitor DMQUB19 RN Synthesis of stable and potent delta/mu opioid peptides: analogues of H-Tyr-c[D-Cys-Gly-Phe-D-Cys]-OH by ring-closing metathesis. J Med Chem. 2007 Jun 28;50(13):3138-42. DMQUB19 RU https://pubmed.ncbi.nlm.nih.gov/17539621 DMQUB19 DI DMQUB19 DMQUB19 DN Cis-H-Tyr-c[D-AllylGly-Gly-Phe-D-Allylgly]-OH DMQUB19 MI TTQW87Y DMQUB19 MN Opioid receptor kappa (OPRK1) DMQUB19 MT DTT DMQUB19 MA Inhibitor DMQUB19 RN Synthesis of stable and potent delta/mu opioid peptides: analogues of H-Tyr-c[D-Cys-Gly-Phe-D-Cys]-OH by ring-closing metathesis. J Med Chem. 2007 Jun 28;50(13):3138-42. DMQUB19 RU https://pubmed.ncbi.nlm.nih.gov/17539621 DMQUB19 DI DMQUB19 DMQUB19 DN Cis-H-Tyr-c[D-AllylGly-Gly-Phe-D-Allylgly]-OH DMQUB19 MI TTKWM86 DMQUB19 MN Opioid receptor mu (MOP) DMQUB19 MT DTT DMQUB19 MA Inhibitor DMQUB19 RN Synthesis of stable and potent delta/mu opioid peptides: analogues of H-Tyr-c[D-Cys-Gly-Phe-D-Cys]-OH by ring-closing metathesis. J Med Chem. 2007 Jun 28;50(13):3138-42. DMQUB19 RU https://pubmed.ncbi.nlm.nih.gov/17539621 DM75SO4 DI DM75SO4 DM75SO4 DN Cis-N,5-dibenzyl-6-oxomorpholine-3-carboxamide DM75SO4 MI TT729IR DM75SO4 MN Voltage-gated calcium channel alpha Cav3.1 (CACNA1G) DM75SO4 MT DTT DM75SO4 MA Inhibitor DM75SO4 RN Morpholin-2-one derivatives as novel selective T-type Ca2+ channel blockers. Bioorg Med Chem Lett. 2006 Oct 1;16(19):5244-8. DM75SO4 RU https://pubmed.ncbi.nlm.nih.gov/16876404 DM75SO4 DI DM75SO4 DM75SO4 DN Cis-N,5-dibenzyl-6-oxomorpholine-3-carboxamide DM75SO4 MI TTZPWGN DM75SO4 MN Voltage-gated calcium channel alpha Cav3.2 (CACNA1H) DM75SO4 MT DTT DM75SO4 MA Inhibitor DM75SO4 RN Morpholin-2-one derivatives as novel selective T-type Ca2+ channel blockers. Bioorg Med Chem Lett. 2006 Oct 1;16(19):5244-8. DM75SO4 RU https://pubmed.ncbi.nlm.nih.gov/16876404 DM7TU1I DI DM7TU1I DM7TU1I DN Cis-N-oleoylcyclopropanolamide DM7TU1I MI TT6OEDT DM7TU1I MN Cannabinoid receptor 1 (CB1) DM7TU1I MT DTT DM7TU1I MA Inhibitor DM7TU1I RN Conformationally constrained fatty acid ethanolamides as cannabinoid and vanilloid receptor probes. J Med Chem. 2009 May 14;52(9):3001-9. DM7TU1I RU https://pubmed.ncbi.nlm.nih.gov/19361197 DM7TU1I DI DM7TU1I DM7TU1I DN Cis-N-oleoylcyclopropanolamide DM7TU1I MI TTMSFAW DM7TU1I MN Cannabinoid receptor 2 (CB2) DM7TU1I MT DTT DM7TU1I MA Inhibitor DM7TU1I RN Conformationally constrained fatty acid ethanolamides as cannabinoid and vanilloid receptor probes. J Med Chem. 2009 May 14;52(9):3001-9. DM7TU1I RU https://pubmed.ncbi.nlm.nih.gov/19361197 DM0N634 DI DM0N634 DM0N634 DN CITCO DM0N634 MI TTRANFM DM0N634 MN Orphan nuclear receptor NR1I3 (NR1I3) DM0N634 MT DTT DM0N634 MA Agonist DM0N634 RN Identification of a novel human constitutive androstane receptor (CAR) agonist and its use in the identification of CAR target genes. J Biol Chem. 2003 May 9;278(19):17277-83. DM0N634 RU https://pubmed.ncbi.nlm.nih.gov/12611900 DMCIM9A DI DMCIM9A DMCIM9A DN Citraconic acid DMCIM9A MI TTHDSE2 DMCIM9A MN Bacterial Fumarate reductase flavoprotein (Bact frdA) DMCIM9A MT DTT DMCIM9A MA Inhibitor DMCIM9A RN DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Nucleic Acids Res. 2011 Jan;39(Database issue):D1035-41. DMCIM9A RU https://pubmed.ncbi.nlm.nih.gov/21059682 DM53ZGY DI DM53ZGY DM53ZGY DN citral DM53ZGY MI TTBECWA DM53ZGY MN Transient receptor potential cation channel V2 (TRPV2) DM53ZGY MT DTT DM53ZGY MA Blocker (channel blocker) DM53ZGY RN Citral sensing by Transient [corrected] receptor potential channels in dorsal root ganglion neurons. PLoS One. 2008 May 7;3(5):e2082. DM53ZGY RU https://pubmed.ncbi.nlm.nih.gov/18461159 DM53ZGY DI DM53ZGY DM53ZGY DN citral DM53ZGY MI TT946IA DM53ZGY MN Transient receptor potential cation channel V3 (TRPV3) DM53ZGY MT DTT DM53ZGY MA Activator DM53ZGY RN Citral sensing by Transient [corrected] receptor potential channels in dorsal root ganglion neurons. PLoS One. 2008 May 7;3(5):e2082. DM53ZGY RU https://pubmed.ncbi.nlm.nih.gov/18461159 DM80YI7 DI DM80YI7 DM80YI7 DN citric acid DM80YI7 MI TTTSOUD DM80YI7 MN Candida Cytochrome P450 51 (Candi ERG11) DM80YI7 MT DTT DM80YI7 MA Binder DM80YI7 RN Chemosensitization of fluconazole resistance in Saccharomyces cerevisiae and pathogenic fungi by a D-octapeptide derivative. Antimicrob Agents Chemother. 2004 Apr;48(4):1256-71. DM80YI7 RU https://pubmed.ncbi.nlm.nih.gov/15047528 DM80YI7 DI DM80YI7 DM80YI7 DN citric acid DM80YI7 MI TTAHD89 DM80YI7 MN Polycystic kidney disease 2-like 1 (TRPP2) DM80YI7 MT DTT DM80YI7 MA Activator DM80YI7 RN Transient receptor potential family members PKD1L3 and PKD2L1 form a candidate sour taste receptor. Proc Natl Acad Sci U S A. 2006 Aug 15;103(33):12569-74. DM80YI7 RU https://pubmed.ncbi.nlm.nih.gov/16891422 DM80YI7 DI DM80YI7 DM80YI7 DN citric acid DM80YI7 MI TTKP2SU DM80YI7 MN Transient receptor potential cation channel V4 (TRPV4) DM80YI7 MT DTT DM80YI7 MA Activator DM80YI7 RN Impaired pressure sensation in mice lacking TRPV4. J Biol Chem. 2003 Jun 20;278(25):22664-8. DM80YI7 RU https://pubmed.ncbi.nlm.nih.gov/12692122 DMH204Y DI DMH204Y DMH204Y DN CKD-533 DMH204Y MI TTJ0IQB DMH204Y MN Phosphodiesterase 5A (PDE5A) DMH204Y MT DTT DMH204Y MA Inhibitor DMH204Y RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1304). DMH204Y RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1304 DML8MSC DI DML8MSC DML8MSC DN CL 385319 DML8MSC MI TTF4CAM DML8MSC MN Influenza Hemagglutinin (Influ HA) DML8MSC MT DTT DML8MSC MA Inhibitor DML8MSC RN Structure of influenza hemagglutinin in complex with an inhibitor of membrane fusion. Proc Natl Acad Sci U S A. 2008 Nov 18;105(46):17736-41. DML8MSC RU https://pubmed.ncbi.nlm.nih.gov/19004788 DMB6XUY DI DMB6XUY DMB6XUY DN CL-205086 DMB6XUY MI DEX5D46 DMB6XUY MN Oxygen-insensitive NADPH nitroreductase A (nfsA) DMB6XUY MT DME DMB6XUY MA Metabolism DMB6XUY RN Delamanid is not metabolized by Salmonella or human nitroreductases: a possible mechanism for the lack of mutagenicity. Regul Toxicol Pharmacol. 2017 Mar;84:1-8. DMB6XUY RU https://pubmed.ncbi.nlm.nih.gov/27988333 DMB6XUY DI DMB6XUY DMB6XUY DN CL-205086 DMB6XUY MI DEOWDK1 DMB6XUY MN Oxygen-insensitive NADPH nitroreductase B (nfsB) DMB6XUY MT DME DMB6XUY MA Metabolism DMB6XUY RN Delamanid is not metabolized by Salmonella or human nitroreductases: a possible mechanism for the lack of mutagenicity. Regul Toxicol Pharmacol. 2017 Mar;84:1-8. DMB6XUY RU https://pubmed.ncbi.nlm.nih.gov/27988333 DMW3RLB DI DMW3RLB DMW3RLB DN CL-301 DMW3RLB MI TTS087L DMW3RLB MN Solute carrier family 12 member 1 (SLC12A1) DMW3RLB MT DTT DMW3RLB MA Modulator DMW3RLB RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 969). DMW3RLB RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=969 DMLQZGJ DI DMLQZGJ DMLQZGJ DN CL-385004 DMLQZGJ MI TT4TFGN DMLQZGJ MN Vasopressin V1a receptor (V1AR) DMLQZGJ MT DTT DMLQZGJ MA Antagonist DMLQZGJ RN Nonpeptide vasopressin receptor antagonists: development of selective and orally active V1a, V2 and V1b receptor ligands. Prog Brain Res. 2002;139:197-210. DMLQZGJ RU https://pubmed.ncbi.nlm.nih.gov/12436936 DMLQZGJ DI DMLQZGJ DMLQZGJ DN CL-385004 DMLQZGJ MI TTK8R02 DMLQZGJ MN Vasopressin V2 receptor (V2R) DMLQZGJ MT DTT DMLQZGJ MA Antagonist DMLQZGJ RN Nonpeptide vasopressin receptor antagonists: development of selective and orally active V1a, V2 and V1b receptor ligands. Prog Brain Res. 2002;139:197-210. DMLQZGJ RU https://pubmed.ncbi.nlm.nih.gov/12436936 DMLKFZC DI DMLKFZC DMLKFZC DN CL-387785 DMLKFZC MI TTGKNB4 DMLKFZC MN Epidermal growth factor receptor (EGFR) DMLKFZC MT DTT DMLKFZC MA Inhibitor DMLKFZC RN Computational studies of epidermal growth factor receptor: docking reliability, three-dimensional quantitative structure-activity relationship anal... J Med Chem. 2009 Feb 26;52(4):964-75. DMLKFZC RU https://pubmed.ncbi.nlm.nih.gov/19170633 DMLKFZC DI DMLKFZC DMLKFZC DN CL-387785 DMLKFZC MI TTR5TV4 DMLKFZC MN ERBB2 messenger RNA (HER2 mRNA) DMLKFZC MT DTT DMLKFZC MA Inhibitor DMLKFZC RN Tyrosine kinase inhibitors. 19. 6-Alkynamides of 4-anilinoquinazolines and 4-anilinopyrido[3,4-d]pyrimidines as irreversible inhibitors of the erbB... J Med Chem. 2006 Feb 23;49(4):1475-85. DMLKFZC RU https://pubmed.ncbi.nlm.nih.gov/16480284 DMLKFZC DI DMLKFZC DMLKFZC DN CL-387785 DMLKFZC MI TTWALCO DMLKFZC MN HER4 messenger RNA (ERBB4 mRNA) DMLKFZC MT DTT DMLKFZC MA Inhibitor DMLKFZC RN Tyrosine kinase inhibitors. 19. 6-Alkynamides of 4-anilinoquinazolines and 4-anilinopyrido[3,4-d]pyrimidines as irreversible inhibitors of the erbB... J Med Chem. 2006 Feb 23;49(4):1475-85. DMLKFZC RU https://pubmed.ncbi.nlm.nih.gov/16480284 DM9AFZ3 DI DM9AFZ3 DM9AFZ3 DN CL-5343 DM9AFZ3 MI TTUNARX DM9AFZ3 MN Carbonic anhydrase (CA) DM9AFZ3 MT DTT DM9AFZ3 MA Inhibitor DM9AFZ3 RN Carbonic anhydrase inhibitors. The X-ray crystal structure of human isoform II in adduct with an adamantyl analogue of acetazolamide resides in a l... Bioorg Med Chem Lett. 2010 Aug 1;20(15):4376-81. DM9AFZ3 RU https://pubmed.ncbi.nlm.nih.gov/20605094 DM9AFZ3 DI DM9AFZ3 DM9AFZ3 DN CL-5343 DM9AFZ3 MI TTHQPL7 DM9AFZ3 MN Carbonic anhydrase I (CA-I) DM9AFZ3 MT DTT DM9AFZ3 MA Inhibitor DM9AFZ3 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2597). DM9AFZ3 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2597 DM9AFZ3 DI DM9AFZ3 DM9AFZ3 DN CL-5343 DM9AFZ3 MI TTANPDJ DM9AFZ3 MN Carbonic anhydrase II (CA-II) DM9AFZ3 MT DTT DM9AFZ3 MA Inhibitor DM9AFZ3 RN Synthesis, characterization and antiglaucoma activity of some novel pyrazole derivatives of 5-amino-1,3,4-thiadiazole-2-sulfonamide. Eur J Med Chem. 2010 Nov;45(11):4769-73. DM9AFZ3 RU https://pubmed.ncbi.nlm.nih.gov/20724038 DM9AFZ3 DI DM9AFZ3 DM9AFZ3 DN CL-5343 DM9AFZ3 MI TTZHA0O DM9AFZ3 MN Carbonic anhydrase IV (CA-IV) DM9AFZ3 MT DTT DM9AFZ3 MA Inhibitor DM9AFZ3 RN Carbonic anhydrase inhibitors. The X-ray crystal structure of human isoform II in adduct with an adamantyl analogue of acetazolamide resides in a l... Bioorg Med Chem Lett. 2010 Aug 1;20(15):4376-81. DM9AFZ3 RU https://pubmed.ncbi.nlm.nih.gov/20605094 DM9AFZ3 DI DM9AFZ3 DM9AFZ3 DN CL-5343 DM9AFZ3 MI TT2LVK8 DM9AFZ3 MN Carbonic anhydrase IX (CA-IX) DM9AFZ3 MT DTT DM9AFZ3 MA Inhibitor DM9AFZ3 RN Carbonic anhydrase inhibitors. The X-ray crystal structure of human isoform II in adduct with an adamantyl analogue of acetazolamide resides in a l... Bioorg Med Chem Lett. 2010 Aug 1;20(15):4376-81. DM9AFZ3 RU https://pubmed.ncbi.nlm.nih.gov/20605094 DM9AFZ3 DI DM9AFZ3 DM9AFZ3 DN CL-5343 DM9AFZ3 MI TTCFSPE DM9AFZ3 MN Carbonic anhydrase VI (CA-VI) DM9AFZ3 MT DTT DM9AFZ3 MA Inhibitor DM9AFZ3 RN Carbonic anhydrase inhibitors. The X-ray crystal structure of human isoform II in adduct with an adamantyl analogue of acetazolamide resides in a l... Bioorg Med Chem Lett. 2010 Aug 1;20(15):4376-81. DM9AFZ3 RU https://pubmed.ncbi.nlm.nih.gov/20605094 DM9AFZ3 DI DM9AFZ3 DM9AFZ3 DN CL-5343 DM9AFZ3 MI TTSYM0R DM9AFZ3 MN Carbonic anhydrase XII (CA-XII) DM9AFZ3 MT DTT DM9AFZ3 MA Inhibitor DM9AFZ3 RN Carbonic anhydrase inhibitors. The X-ray crystal structure of human isoform II in adduct with an adamantyl analogue of acetazolamide resides in a l... Bioorg Med Chem Lett. 2010 Aug 1;20(15):4376-81. DM9AFZ3 RU https://pubmed.ncbi.nlm.nih.gov/20605094 DM9AFZ3 DI DM9AFZ3 DM9AFZ3 DN CL-5343 DM9AFZ3 MI TTEYTKG DM9AFZ3 MN Carbonic anhydrase XIV (CA-XIV) DM9AFZ3 MT DTT DM9AFZ3 MA Inhibitor DM9AFZ3 RN Carbonic anhydrase inhibitors. The X-ray crystal structure of human isoform II in adduct with an adamantyl analogue of acetazolamide resides in a l... Bioorg Med Chem Lett. 2010 Aug 1;20(15):4376-81. DM9AFZ3 RU https://pubmed.ncbi.nlm.nih.gov/20605094 DMP3MDS DI DMP3MDS DMP3MDS DN CL82198 DMP3MDS MI TTHY57M DMP3MDS MN Matrix metalloproteinase-13 (MMP-13) DMP3MDS MT DTT DMP3MDS MA Inhibitor DMP3MDS RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1637). DMP3MDS RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1637 DMRV89X DI DMRV89X DMRV89X DN Cl-amidine DMRV89X MI TTSCHFW DMRV89X MN Peptidyl arginine deiminase type III (PADI3) DMRV89X MT DTT DMRV89X MA Inhibitor DMRV89X RN Identification of multiple structurally distinct, nonpeptidic small molecule inhibitors of protein arginine deiminase 3 using a substrate-based fragment method. J Am Chem Soc. 2015 Mar 18;137(10):3616-21. DMRV89X RU https://pubmed.ncbi.nlm.nih.gov/25742366 DMRV89X DI DMRV89X DMRV89X DN Cl-amidine DMRV89X MI TTQHAXM DMRV89X MN Peptidyl arginine deiminase type IV (PADI4) DMRV89X MT DTT DMRV89X MA Inhibitor DMRV89X RN Identification of multiple structurally distinct, nonpeptidic small molecule inhibitors of protein arginine deiminase 3 using a substrate-based fragment method. J Am Chem Soc. 2015 Mar 18;137(10):3616-21. DMRV89X RU https://pubmed.ncbi.nlm.nih.gov/25742366 DMIX347 DI DMIX347 DMIX347 DN CLAVARINONE DMIX347 MI TT7WZIJ DMIX347 MN CAAX farnesyltransferase beta (FNTB) DMIX347 MT DTT DMIX347 MA Inhibitor DMIX347 RN Clavaric acid and steroidal analogues as Ras- and FPP-directed inhibitors of human farnesyl-protein transferase. J Med Chem. 1998 Nov 5;41(23):4492-501. DMIX347 RU https://pubmed.ncbi.nlm.nih.gov/9804689 DMIX347 DI DMIX347 DMIX347 DN CLAVARINONE DMIX347 MI TTXQKM3 DMIX347 MN Farnesyl protein transferase (Ftase) DMIX347 MT DTT DMIX347 MA Inhibitor DMIX347 RN Clavaric acid and steroidal analogues as Ras- and FPP-directed inhibitors of human farnesyl-protein transferase. J Med Chem. 1998 Nov 5;41(23):4492-501. DMIX347 RU https://pubmed.ncbi.nlm.nih.gov/9804689 DMAJNYM DI DMAJNYM DMAJNYM DN Clavulanate+Amoxicillin DMAJNYM MI TTHI19T DMAJNYM MN Staphylococcus Beta-lactamase (Stap-coc blaZ) DMAJNYM MT DTT DMAJNYM MA Inhibitor DMAJNYM RN Emerging therapies for the treatment and prevention of otitis media. Expert Opin Emerg Drugs. 2006 May;11(2):251-64. DMAJNYM RU https://pubmed.ncbi.nlm.nih.gov/16634700 DMTLOU6 DI DMTLOU6 DMTLOU6 DN CLEBOPRIDE DMTLOU6 MI TT1RS9F DMTLOU6 MN Acetylcholinesterase (AChE) DMTLOU6 MT DTT DMTLOU6 MA Inhibitor DMTLOU6 RN Efficient method for high-throughput virtual screening based on flexible docking: discovery of novel acetylcholinesterase inhibitors. J Med Chem. 2004 Sep 23;47(20):4818-28. DMTLOU6 RU https://pubmed.ncbi.nlm.nih.gov/15369385 DMTLOU6 DI DMTLOU6 DMTLOU6 DN CLEBOPRIDE DMTLOU6 MI TTEX248 DMTLOU6 MN Dopamine D2 receptor (D2R) DMTLOU6 MT DTT DMTLOU6 MA Inhibitor DMTLOU6 RN Synthesis and structure-affinity relationships of novel N-(1-ethyl-4-methylhexahydro-1,4-diazepin-6-yl)pyridine-3-carboxamides with potent serotoni... J Med Chem. 2003 Feb 27;46(5):702-15. DMTLOU6 RU https://pubmed.ncbi.nlm.nih.gov/12593651 DM4SKYA DI DM4SKYA DM4SKYA DN CLEMATOMANDSHURICA SAPONIN A DM4SKYA MI TTVKILB DM4SKYA MN Prostaglandin G/H synthase 2 (COX-2) DM4SKYA MT DTT DM4SKYA MA Inhibitor DM4SKYA RN Triterpene saponins from clematis mandshurica. J Nat Prod. 2006 Nov;69(11):1591-5. DM4SKYA RU https://pubmed.ncbi.nlm.nih.gov/17125227 DMNWXOC DI DMNWXOC DMNWXOC DN CLEMATOMANDSHURICA SAPONIN B DMNWXOC MI TTVKILB DMNWXOC MN Prostaglandin G/H synthase 2 (COX-2) DMNWXOC MT DTT DMNWXOC MA Inhibitor DMNWXOC RN Triterpene saponins from clematis mandshurica. J Nat Prod. 2006 Nov;69(11):1591-5. DMNWXOC RU https://pubmed.ncbi.nlm.nih.gov/17125227 DM9WUHD DI DM9WUHD DM9WUHD DN Clik60 DM9WUHD MI TTUMQVO DM9WUHD MN Cathepsin S (CTSS) DM9WUHD MT DTT DM9WUHD MA Inhibitor DM9WUHD RN Cathepsin S inhibitor prevents autoantigen presentation and autoimmunity. J Clin Invest. 2002 Aug;110(3):361-9. DM9WUHD RU https://pubmed.ncbi.nlm.nih.gov/12163455 DMS58P1 DI DMS58P1 DMS58P1 DN Clinopodic acid C DMS58P1 MI TTLM12X DMS58P1 MN Matrix metalloproteinase-2 (MMP-2) DMS58P1 MT DTT DMS58P1 MA Inhibitor DMS58P1 RN Matrix metalloproteinase-2 inhibitors from Clinopodium chinense var. parviflorum. J Nat Prod. 2009 Aug;72(8):1379-84. DMS58P1 RU https://pubmed.ncbi.nlm.nih.gov/19711986 DM537OH DI DM537OH DM537OH DN Clobenpropit DM537OH MI TT9JNIC DM537OH MN Histamine H3 receptor (H3R) DM537OH MT DTT DM537OH MA Antagonist DM537OH RN The histamine H3 receptor: from gene cloning to H3 receptor drugs. Nat Rev Drug Discov. 2005 Feb;4(2):107-20. DM537OH RU https://pubmed.ncbi.nlm.nih.gov/15665857 DM537OH DI DM537OH DM537OH DN Clobenpropit DM537OH MI TTXJ178 DM537OH MN Histamine H4 receptor (H4R) DM537OH MT DTT DM537OH MA Agonist DM537OH RN Clobenpropit analogs as dual activity ligands for the histamine H3 and H4 receptors: synthesis, pharmacological evaluation, and cross-target QSAR s... Bioorg Med Chem. 2009 Jun 1;17(11):3987-94. DM537OH RU https://pubmed.ncbi.nlm.nih.gov/19414267 DMZLMJH DI DMZLMJH DMZLMJH DN Clocinnamox DMZLMJH MI TT27RFC DMZLMJH MN Opioid receptor delta (OPRD1) DMZLMJH MT DTT DMZLMJH MA Inhibitor DMZLMJH RN 14 beta-O-cinnamoylnaltrexone and related dihydrocodeinones are mu opioid receptor partial agonists with predominant antagonist activity. J Med Chem. 2009 Mar 26;52(6):1553-7. DMZLMJH RU https://pubmed.ncbi.nlm.nih.gov/19253983 DMZLMJH DI DMZLMJH DMZLMJH DN Clocinnamox DMZLMJH MI TTQW87Y DMZLMJH MN Opioid receptor kappa (OPRK1) DMZLMJH MT DTT DMZLMJH MA Inhibitor DMZLMJH RN 14 beta-O-cinnamoylnaltrexone and related dihydrocodeinones are mu opioid receptor partial agonists with predominant antagonist activity. J Med Chem. 2009 Mar 26;52(6):1553-7. DMZLMJH RU https://pubmed.ncbi.nlm.nih.gov/19253983 DMZLMJH DI DMZLMJH DMZLMJH DN Clocinnamox DMZLMJH MI TTKWM86 DMZLMJH MN Opioid receptor mu (MOP) DMZLMJH MT DTT DMZLMJH MA Inhibitor DMZLMJH RN 14 beta-O-cinnamoylnaltrexone and related dihydrocodeinones are mu opioid receptor partial agonists with predominant antagonist activity. J Med Chem. 2009 Mar 26;52(6):1553-7. DMZLMJH RU https://pubmed.ncbi.nlm.nih.gov/19253983 DMALRU9 DI DMALRU9 DMALRU9 DN Clodinafop DMALRU9 MI TTYAWV0 DMALRU9 MN Plasmodium Acetyl-CoA carboxylase 1 (Malaria ACC1) DMALRU9 MT DTT DMALRU9 MA Binder DMALRU9 RN The apicoplast as an antimalarial drug target. Drug Resist Updat. 2001 Jun;4(3):145-51. DMALRU9 RU https://pubmed.ncbi.nlm.nih.gov/11768328 DMQ37OP DI DMQ37OP DMQ37OP DN clofilium DMQ37OP MI TTW0CMT DMQ37OP MN Voltage-gated potassium channel Kv1.5 (KCNA5) DMQ37OP MT DTT DMQ37OP MA Blocker (channel blocker) DMQ37OP RN Mechanism of clofilium block of the human Kv1.5 delayed rectifier potassium channel. Mol Pharmacol. 1995 Jan;47(1):198-205. DMQ37OP RU https://pubmed.ncbi.nlm.nih.gov/7838129 DMQ37OP DI DMQ37OP DMQ37OP DN clofilium DMQ37OP MI TT9XKUC DMQ37OP MN Voltage-gated potassium channel Kv10.1 (KCNH1) DMQ37OP MT DTT DMQ37OP MA Blocker (channel blocker) DMQ37OP RN Inhibition of hEAG1 and hERG1 potassium channels by clofilium and its tertiary analogue LY97241. Br J Pharmacol. 2003 Jan;138(1):161-71. DMQ37OP RU https://pubmed.ncbi.nlm.nih.gov/12522086 DMH01JV DI DMH01JV DMH01JV DN cloprostenol DMH01JV MI TTNVEIR DMH01JV MN Prostaglandin D2 receptor (PTGDR) DMH01JV MT DTT DMH01JV MA Agonist DMH01JV RN The utilization of recombinant prostanoid receptors to determine the affinities and selectivities of prostaglandins and related analogs. Biochim Biophys Acta. 2000 Jan 17;1483(2):285-93. DMH01JV RU https://pubmed.ncbi.nlm.nih.gov/10634944 DMH01JV DI DMH01JV DMH01JV DN cloprostenol DMH01JV MI TTG1QMU DMH01JV MN Prostaglandin E2 receptor EP1 (PTGER1) DMH01JV MT DTT DMH01JV MA Agonist DMH01JV RN Cloned human EP1 prostanoid receptor pharmacology characterized using radioligand binding techniques. J Pharm Pharmacol. 2002 Apr;54(4):539-47. DMH01JV RU https://pubmed.ncbi.nlm.nih.gov/11999132 DMH01JV DI DMH01JV DMH01JV DN cloprostenol DMH01JV MI TTPNGDE DMH01JV MN Prostaglandin E2 receptor EP3 (PTGER3) DMH01JV MT DTT DMH01JV MA Agonist DMH01JV RN The utilization of recombinant prostanoid receptors to determine the affinities and selectivities of prostaglandins and related analogs. Biochim Biophys Acta. 2000 Jan 17;1483(2):285-93. DMH01JV RU https://pubmed.ncbi.nlm.nih.gov/10634944 DMH01JV DI DMH01JV DMH01JV DN cloprostenol DMH01JV MI TTT2ZAR DMH01JV MN Prostaglandin F2-alpha receptor (PTGFR) DMH01JV MT DTT DMH01JV MA Agonist DMH01JV RN The utilization of recombinant prostanoid receptors to determine the affinities and selectivities of prostaglandins and related analogs. Biochim Biophys Acta. 2000 Jan 17;1483(2):285-93. DMH01JV RU https://pubmed.ncbi.nlm.nih.gov/10634944 DMH01JV DI DMH01JV DMH01JV DN cloprostenol DMH01JV MI TT2O84V DMH01JV MN Thromboxane A2 receptor (TBXA2R) DMH01JV MT DTT DMH01JV MA Agonist DMH01JV RN The utilization of recombinant prostanoid receptors to determine the affinities and selectivities of prostaglandins and related analogs. Biochim Biophys Acta. 2000 Jan 17;1483(2):285-93. DMH01JV RU https://pubmed.ncbi.nlm.nih.gov/10634944 DMH7GKB DI DMH7GKB DMH7GKB DN Cloranolol DMH7GKB MI DECB0K3 DMH7GKB MN Cytochrome P450 2D6 (CYP2D6) DMH7GKB MT DME DMH7GKB MA Metabolism DMH7GKB RN Application of substrate depletion assay to evaluation of CYP isoforms responsible for stereoselective metabolism of carvedilol. Drug Metab Pharmacokinet. 2016 Dec;31(6):425-432. DMH7GKB RU https://www.ncbi.nlm.nih.gov/pubmed/?term=27836712 DMLPXNC DI DMLPXNC DMLPXNC DN Clorindione DMLPXNC MI DE4LYSA DMLPXNC MN Cytochrome P450 3A4 (CYP3A4) DMLPXNC MT DME DMLPXNC MA Metabolism DMLPXNC RN CYP3A time-dependent inhibition risk assessment validated with 400 reference drugs. Drug Metab Dispos. 2011 Jun;39(6):1039-46. DMLPXNC RU https://www.ncbi.nlm.nih.gov/pubmed/?term=21383203 DMD5FIU DI DMD5FIU DMD5FIU DN Clorobiocin DMD5FIU MI TT0IHXV DMD5FIU MN DNA topoisomerase II (TOP2) DMD5FIU MT DTT DMD5FIU MA Inhibitor DMD5FIU RN The high-resolution crystal structure of a 24-kDa gyrase B fragment from E.coli complexed with one of the most potent coumarin inhibitors, clorobiocin. Proteins. 1997 May;28(1):41-52. DMD5FIU RU https://pubmed.ncbi.nlm.nih.gov/9144789 DMU6FOG DI DMU6FOG DMU6FOG DN Clorsulon DMU6FOG MI TTHJWVK DMU6FOG MN Mycobacterium Bisphosphoglycerate phosphoglycerate mutase (MycB gpmI) DMU6FOG MT DTT DMU6FOG MA Inhibitor DMU6FOG RN Modes of action of anthelmintic drugs. Vet J. 1997 Jul;154(1):11-34. DMU6FOG RU https://pubmed.ncbi.nlm.nih.gov/9265850 DMWTBG8 DI DMWTBG8 DMWTBG8 DN Clostridial collagenase DMWTBG8 MI TTK982E DMWTBG8 MN Collagen (CO) DMWTBG8 MT DTT DMWTBG8 MA Binder DMWTBG8 RN Collagen as a clinical target: nonoperative treatment of Dupuytren's disease. J Hand Surg Am. 2002 Sep;27(5):788-98. DMWTBG8 RU https://pubmed.ncbi.nlm.nih.gov/12239666 DM1B0PY DI DM1B0PY DM1B0PY DN CLP-635 DM1B0PY MI TTH6UZY DM1B0PY MN Solute carrier family 12 member 5 (SLC12A5) DM1B0PY MT DTT DM1B0PY MA Modulator DM1B0PY RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 972). DM1B0PY RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=972 DM9LSOW DI DM9LSOW DM9LSOW DN CLR-151 DM9LSOW MI TTEX248 DM9LSOW MN Dopamine D2 receptor (D2R) DM9LSOW MT DTT DM9LSOW MA Antagonist DM9LSOW RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 215). DM9LSOW RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=215 DM7TX3D DI DM7TX3D DM7TX3D DN CM-156 DM7TX3D MI TT5TPI6 DM7TX3D MN Opioid receptor sigma 1 (OPRS1) DM7TX3D MT DTT DM7TX3D MA Antagonist DM7TX3D RN Antitussives and substance abuse. Subst Abuse Rehabil. 2013 Nov 6;4:75-82. DM7TX3D RU https://pubmed.ncbi.nlm.nih.gov/24648790 DMXA8K1 DI DMXA8K1 DMXA8K1 DN CM-352 DMXA8K1 MI TTXLEG7 DMXA8K1 MN Matrix metalloproteinase-10 (MMP-10) DMXA8K1 MT DTT DMXA8K1 MA Inhibitor DMXA8K1 RN Discovery and safety profiling of a potent preclinical candidate, (4-[4-[[(3R)-3-(hydroxycarbamoyl)-8-azaspiro[4.5]decan-3-yl]sulfonyl]phenoxy]-N-methylbenzamide) (CM-352), for the prevention and treatment of hemorrhage. J Med Chem. 2015 Apr 9;58(7):2941-57. DMXA8K1 RU https://pubmed.ncbi.nlm.nih.gov/25686022 DMXA8K1 DI DMXA8K1 DMXA8K1 DN CM-352 DMXA8K1 MI TTUZ2L5 DMXA8K1 MN Matrix metalloproteinase-3 (MMP-3) DMXA8K1 MT DTT DMXA8K1 MA Inhibitor DMXA8K1 RN Discovery and safety profiling of a potent preclinical candidate, (4-[4-[[(3R)-3-(hydroxycarbamoyl)-8-azaspiro[4.5]decan-3-yl]sulfonyl]phenoxy]-N-methylbenzamide) (CM-352), for the prevention and treatment of hemorrhage. J Med Chem. 2015 Apr 9;58(7):2941-57. DMXA8K1 RU https://pubmed.ncbi.nlm.nih.gov/25686022 DM6PFG0 DI DM6PFG0 DM6PFG0 DN CMET Avimer polypeptides DM6PFG0 MI TTNDSF4 DM6PFG0 MN Proto-oncogene c-Met (MET) DM6PFG0 MT DTT DM6PFG0 MA Inhibitor DM6PFG0 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1815). DM6PFG0 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1815 DMYPG01 DI DMYPG01 DMYPG01 DN CMI-1145 DMYPG01 MI TTYEG6Q DMYPG01 MN Muscarinic acetylcholine receptor M2 (CHRM2) DMYPG01 MT DTT DMYPG01 MA Agonist DMYPG01 RN Evaluation of muscarinic agonist-induced analgesia in muscarinic acetylcholine receptor knockout mice. Mol Pharmacol. 2002 Nov;62(5):1084-93. DMYPG01 RU https://pubmed.ncbi.nlm.nih.gov/12391271 DMYPG01 DI DMYPG01 DMYPG01 DN CMI-1145 DMYPG01 MI TTQ3JTF DMYPG01 MN Muscarinic acetylcholine receptor M4 (CHRM4) DMYPG01 MT DTT DMYPG01 MA Agonist DMYPG01 RN Evaluation of muscarinic agonist-induced analgesia in muscarinic acetylcholine receptor knockout mice. Mol Pharmacol. 2002 Nov;62(5):1084-93. DMYPG01 RU https://pubmed.ncbi.nlm.nih.gov/12391271 DM4PWDJ DI DM4PWDJ DM4PWDJ DN CMI-489 DM4PWDJ MI TT4H1MQ DM4PWDJ MN Neuronal acetylcholine receptor alpha-4 (CHRNA4) DM4PWDJ MT DTT DM4PWDJ MA Inhibitor DM4PWDJ RN Synthesis and nicotinic acetylcholine receptor binding properties of bridged and fused ring analogues of epibatidine. J Med Chem. 2007 Dec 13;50(25):6383-91. DM4PWDJ RU https://pubmed.ncbi.nlm.nih.gov/17994682 DM4PWDJ DI DM4PWDJ DM4PWDJ DN CMI-489 DM4PWDJ MI TT5KPZR DM4PWDJ MN Neuronal acetylcholine receptor beta-2 (CHRNB2) DM4PWDJ MT DTT DM4PWDJ MA Inhibitor DM4PWDJ RN Synthesis and nicotinic acetylcholine receptor binding properties of bridged and fused ring analogues of epibatidine. J Med Chem. 2007 Dec 13;50(25):6383-91. DM4PWDJ RU https://pubmed.ncbi.nlm.nih.gov/17994682 DMT9YKG DI DMT9YKG DMT9YKG DN CMI-936 DMT9YKG MI TTYEG6Q DMT9YKG MN Muscarinic acetylcholine receptor M2 (CHRM2) DMT9YKG MT DTT DMT9YKG MA Agonist DMT9YKG RN Evaluation of muscarinic agonist-induced analgesia in muscarinic acetylcholine receptor knockout mice. Mol Pharmacol. 2002 Nov;62(5):1084-93. DMT9YKG RU https://pubmed.ncbi.nlm.nih.gov/12391271 DMT9YKG DI DMT9YKG DMT9YKG DN CMI-936 DMT9YKG MI TTQ3JTF DMT9YKG MN Muscarinic acetylcholine receptor M4 (CHRM4) DMT9YKG MT DTT DMT9YKG MA Agonist DMT9YKG RN Evaluation of muscarinic agonist-induced analgesia in muscarinic acetylcholine receptor knockout mice. Mol Pharmacol. 2002 Nov;62(5):1084-93. DMT9YKG RU https://pubmed.ncbi.nlm.nih.gov/12391271 DMM9K5S DI DMM9K5S DMM9K5S DN Cmp-2-Keto-3-Deoxy-Octulosonic Acid DMM9K5S MI TTQ8J1V DMM9K5S MN Bacterial Deoxy-manno-octulosonate cytidylyltransferase (Bact kdsB) DMM9K5S MT DTT DMM9K5S MA Inhibitor DMM9K5S RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMM9K5S RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMBT2ZW DI DMBT2ZW DMBT2ZW DN cmp5 DMBT2ZW MI TTR1D7X DMBT2ZW MN Protein arginine methyltransferase 5 (PRMT5) DMBT2ZW MT DTT DMBT2ZW MA Inhibitor DMBT2ZW RN Selective inhibition of protein arginine methyltransferase 5 blocks initiation and maintenance of B-cell transformation. Blood. 2015 Apr 16;125(16):2530-43. DMBT2ZW RU https://pubmed.ncbi.nlm.nih.gov/25742700 DM241YW DI DM241YW DM241YW DN CMP-6 DM241YW MI TTRMX3V DM241YW MN Janus kinase 2 (JAK-2) DM241YW MT DTT DM241YW MA Inhibitor DM241YW RN Photochemical preparation of a pyridone containing tetracycle: a Jak protein kinase inhibitor. Bioorg Med Chem Lett. 2002 Apr 22;12(8):1219-23. DM241YW RU https://pubmed.ncbi.nlm.nih.gov/11934592 DM241YW DI DM241YW DM241YW DN CMP-6 DM241YW MI TTT7PJU DM241YW MN Janus kinase 3 (JAK-3) DM241YW MT DTT DM241YW MA Inhibitor DM241YW RN Photochemical preparation of a pyridone containing tetracycle: a Jak protein kinase inhibitor. Bioorg Med Chem Lett. 2002 Apr 22;12(8):1219-23. DM241YW RU https://pubmed.ncbi.nlm.nih.gov/11934592 DM241YW DI DM241YW DM241YW DN CMP-6 DM241YW MI TTBYWP2 DM241YW MN TYK2 tyrosine kinase (TYK2) DM241YW MT DTT DM241YW MA Inhibitor DM241YW RN A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases. Proc Natl Acad Sci U S A. 2007 Dec 18;104(51):20523-8. DM241YW RU https://pubmed.ncbi.nlm.nih.gov/18077363 DMKNUYF DI DMKNUYF DMKNUYF DN CMPD1 DMKNUYF MI TTMUG9D DMKNUYF MN MAPK-activated protein kinase 2 (MAPKAPK2) DMKNUYF MT DTT DMKNUYF MA Inhibitor DMKNUYF RN Synthesis and in vivo activity of MK2 and MK2 substrate-selective p38alpha(MAPK) inhibitors in Werner syndrome cells. Bioorg Med Chem Lett. 2007 Dec 15;17(24):6832-5. DMKNUYF RU https://pubmed.ncbi.nlm.nih.gov/17964780 DM9IPH4 DI DM9IPH4 DM9IPH4 DN CMPD-167 DM9IPH4 MI TT2CEJG DM9IPH4 MN C-C chemokine receptor type 5 (CCR5) DM9IPH4 MT DTT DM9IPH4 MA Inhibitor DM9IPH4 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 3651). DM9IPH4 RU http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=3651 DMH48YE DI DMH48YE DMH48YE DN CMP-sialic acid DMH48YE MI DTVZIRG DMH48YE MN CMP-sialic acid transporter (SLC35A1) DMH48YE MT DTP DMH48YE MA Substrate DMH48YE RN Disease mutations in CMP-sialic acid transporter SLC35A1 result in abnormal -dystroglycan O-mannosylation, independent from sialic acid. Hum Mol Genet. 2015 Apr 15;24(8):2241-6. DMH48YE RU http://www.ncbi.nlm.nih.gov/pubmed/25552652 DMA5Z2G DI DMA5Z2G DMA5Z2G DN C-myb DMA5Z2G MI TTVKILB DMA5Z2G MN Prostaglandin G/H synthase 2 (COX-2) DMA5Z2G MT DTT DMA5Z2G MA Regulator (upregulator) DMA5Z2G RN Cyclooxygenase-2, a colorectal cancer nonsteroidal anti-inflammatory drug target, is regulated by c-MYB. Cancer Res. 2000 Apr 1;60(7):1805-9. DMA5Z2G RU https://pubmed.ncbi.nlm.nih.gov/10766162 DMJA8I4 DI DMJA8I4 DMJA8I4 DN CN-2097 DMJA8I4 MI TTN9D8E DMJA8I4 MN Glutamate receptor ionotropic NMDA 2B (NMDAR2B) DMJA8I4 MT DTT DMJA8I4 MA Modulator DMJA8I4 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 457). DMJA8I4 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=457 DMFW1JC DI DMFW1JC DMFW1JC DN C-Naphthalen-1-yl-methylamine DMFW1JC MI TTWG9A4 DMFW1JC MN Adrenergic receptor alpha-2A (ADRA2A) DMFW1JC MT DTT DMFW1JC MA Inhibitor DMFW1JC RN Examination of the role of the acidic hydrogen in imparting selectivity of 7-(aminosulfonyl)-1,2,3,4-tetrahydroisoquinoline (SK&F 29661) toward inh... J Med Chem. 1997 Dec 5;40(25):3997-4005. DMFW1JC RU https://pubmed.ncbi.nlm.nih.gov/9406590 DMFW1JC DI DMFW1JC DMFW1JC DN C-Naphthalen-1-yl-methylamine DMFW1JC MI TTWM4TY DMFW1JC MN Adrenergic receptor alpha-2B (ADRA2B) DMFW1JC MT DTT DMFW1JC MA Inhibitor DMFW1JC RN Examination of the role of the acidic hydrogen in imparting selectivity of 7-(aminosulfonyl)-1,2,3,4-tetrahydroisoquinoline (SK&F 29661) toward inh... J Med Chem. 1997 Dec 5;40(25):3997-4005. DMFW1JC RU https://pubmed.ncbi.nlm.nih.gov/9406590 DMFW1JC DI DMFW1JC DMFW1JC DN C-Naphthalen-1-yl-methylamine DMFW1JC MI TT2NUT5 DMFW1JC MN Adrenergic receptor alpha-2C (ADRA2C) DMFW1JC MT DTT DMFW1JC MA Inhibitor DMFW1JC RN Examination of the role of the acidic hydrogen in imparting selectivity of 7-(aminosulfonyl)-1,2,3,4-tetrahydroisoquinoline (SK&F 29661) toward inh... J Med Chem. 1997 Dec 5;40(25):3997-4005. DMFW1JC RU https://pubmed.ncbi.nlm.nih.gov/9406590 DMEVM0J DI DMEVM0J DMEVM0J DN CNICIN DMEVM0J MI TTICX3S DMEVM0J MN Bacterial UDP-N-acetylglucosamine carboxyvinyltransferase (Bact murA) DMEVM0J MT DTT DMEVM0J MA Inhibitor DMEVM0J RN Sesquiterpene lactones are potent and irreversible inhibitors of the antibacterial target enzyme MurA. Bioorg Med Chem Lett. 2006 Nov 1;16(21):5605-9. DMEVM0J RU https://pubmed.ncbi.nlm.nih.gov/16945528 DMTEGNB DI DMTEGNB DMTEGNB DN CNS-1169 DMTEGNB MI TT5TPI6 DMTEGNB MN Opioid receptor sigma 1 (OPRS1) DMTEGNB MT DTT DMTEGNB MA Modulator DMTEGNB RN Antitussives and substance abuse. Subst Abuse Rehabil. 2013 Nov 6;4:75-82. DMTEGNB RU https://pubmed.ncbi.nlm.nih.gov/24648790 DMZ57O1 DI DMZ57O1 DMZ57O1 DN CNTO-736 DMZ57O1 MI TTVIMDE DMZ57O1 MN Glucagon-like peptide 1 receptor (GLP1R) DMZ57O1 MT DTT DMZ57O1 MA Modulator DMZ57O1 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 249). DMZ57O1 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=249 DMDK5BL DI DMDK5BL DMDK5BL DN CNX-010 DMDK5BL MI TTN7BL9 DMDK5BL MN Corticosteroid 11-beta-dehydrogenase 1 (HSD11B1) DMDK5BL MT DTT DMDK5BL MA Inhibitor DMDK5BL RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2763). DMDK5BL RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2763 DM5T401 DI DM5T401 DM5T401 DN CNX-011 DM5T401 MI TTB8FUC DM5T401 MN Free fatty acid receptor 1 (GPR40) DM5T401 MT DTT DM5T401 MA Agonist DM5T401 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 225). DM5T401 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=225 DMTB965 DI DMTB965 DMTB965 DN Cobalt Hexammine Ion DMTB965 MI TTQAOZR DMTB965 MN Bacterial Chorismate synthase (Bact aroC) DMTB965 MT DTT DMTB965 MA Inhibitor DMTB965 RN DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Nucleic Acids Res. 2011 Jan;39(Database issue):D1035-41. DMTB965 RU https://pubmed.ncbi.nlm.nih.gov/21059682 DMJRSIF DI DMJRSIF DMJRSIF DN COCAINE.HCL DMJRSIF MI TTVBI8W DMJRSIF MN Dopamine transporter (DAT) DMJRSIF MT DTT DMJRSIF MA Inhibitor DMJRSIF RN Synthesis and pharmacology of site-specific cocaine abuse treatment agents: restricted rotation analogues of methylphenidate. J Med Chem. 2007 May 31;50(11):2718-31. DMJRSIF RU https://pubmed.ncbi.nlm.nih.gov/17489581 DMJRSIF DI DMJRSIF DMJRSIF DN COCAINE.HCL DMJRSIF MI TT3ROYC DMJRSIF MN Serotonin transporter (SERT) DMJRSIF MT DTT DMJRSIF MA Inhibitor DMJRSIF RN Synthesis and pharmacology of site-specific cocaine abuse treatment agents: restricted rotation analogues of methylphenidate. J Med Chem. 2007 May 31;50(11):2718-31. DMJRSIF RU https://pubmed.ncbi.nlm.nih.gov/17489581 DMCSAIJ DI DMCSAIJ DMCSAIJ DN COCHINCHINENENE B DMCSAIJ MI TT6L509 DMCSAIJ MN Coagulation factor IIa (F2) DMCSAIJ MT DTT DMCSAIJ MA Inhibitor DMCSAIJ RN Anti-Helicobacter pylori and thrombin inhibitory components from Chinese dragon's blood, Dracaena cochinchinensis. J Nat Prod. 2007 Oct;70(10):1570-7. DMCSAIJ RU https://pubmed.ncbi.nlm.nih.gov/17883259 DMIGB7N DI DMIGB7N DMIGB7N DN COCHINCHINENIN B DMIGB7N MI TT6L509 DMIGB7N MN Coagulation factor IIa (F2) DMIGB7N MT DTT DMIGB7N MA Inhibitor DMIGB7N RN Anti-Helicobacter pylori and thrombin inhibitory components from Chinese dragon's blood, Dracaena cochinchinensis. J Nat Prod. 2007 Oct;70(10):1570-7. DMIGB7N RU https://pubmed.ncbi.nlm.nih.gov/17883259 DMOUSWN DI DMOUSWN DMOUSWN DN Cochliobolic acid DMOUSWN MI TTGKNB4 DMOUSWN MN Epidermal growth factor receptor (EGFR) DMOUSWN MT DTT DMOUSWN MA Inhibitor DMOUSWN RN Cochliobolic acid, a novel metabolite produced by Cochliobolus lunatus, inhibits binding of TGF-alpha to the EGF receptor in a SPA assay. J Nat Prod. 1997 Jan;60(1):6-8. DMOUSWN RU https://pubmed.ncbi.nlm.nih.gov/9014347 DMZ1VSI DI DMZ1VSI DMZ1VSI DN COCLAURINE DMZ1VSI MI TTVBI8W DMZ1VSI MN Dopamine transporter (DAT) DMZ1VSI MT DTT DMZ1VSI MA Inhibitor DMZ1VSI RN Effects of various isoquinoline alkaloids on in vitro 3H-dopamine uptake by rat striatal synaptosomes. J Nat Prod. 1995 Oct;58(10):1475-84. DMZ1VSI RU https://pubmed.ncbi.nlm.nih.gov/8676127 DM08WPL DI DM08WPL DM08WPL DN CODEINONE DM08WPL MI TTKWM86 DM08WPL MN Opioid receptor mu (MOP) DM08WPL MT DTT DM08WPL MA Inhibitor DM08WPL RN Live cell monitoring of mu-opioid receptor-mediated G-protein activation reveals strong biological activity of close morphine biosynthetic precursors. J Biol Chem. 2007 Sep 14;282(37):27126-32. DM08WPL RU https://pubmed.ncbi.nlm.nih.gov/17616524 DM1I8LU DI DM1I8LU DM1I8LU DN Coenzyme A DM1I8LU MI TTSEOPJ DM1I8LU MN Bacterial Pantothenate kinase (Bact coaA) DM1I8LU MT DTT DM1I8LU MA Inhibitor DM1I8LU RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DM1I8LU RU https://pubmed.ncbi.nlm.nih.gov/17139284 DM1I8LU DI DM1I8LU DM1I8LU DN Coenzyme A DM1I8LU MI TTC8M31 DM1I8LU MN Carnitine acyltransferase (CRAT) DM1I8LU MT DTT DM1I8LU MA Inhibitor DM1I8LU RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DM1I8LU RU https://pubmed.ncbi.nlm.nih.gov/17139284 DM1I8LU DI DM1I8LU DM1I8LU DN Coenzyme A DM1I8LU MI DTNU9EW DM1I8LU MN Graves disease carrier protein (SLC25A16) DM1I8LU MT DTP DM1I8LU MA Substrate DM1I8LU RN Biochemical characterization of a new mitochondrial transporter of dephosphocoenzyme A in Drosophila melanogaster. Biochim Biophys Acta Bioenerg. 2017 Feb;1858(2):137-146. DM1I8LU RU http://www.ncbi.nlm.nih.gov/pubmed/27836698 DM1I8LU DI DM1I8LU DM1I8LU DN Coenzyme A DM1I8LU MI TTPADOQ DM1I8LU MN HMG-CoA reductase (HMGCR) DM1I8LU MT DTT DM1I8LU MA Inhibitor DM1I8LU RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DM1I8LU RU https://pubmed.ncbi.nlm.nih.gov/17139284 DM1I8LU DI DM1I8LU DM1I8LU DN Coenzyme A DM1I8LU MI DTU4HKJ DM1I8LU MN Mitochondrial coenzyme A transporter SLC25A42 (SLC25A42) DM1I8LU MT DTP DM1I8LU MA Substrate DM1I8LU RN A novel member of solute carrier family 25 (SLC25A42) is a transporter of coenzyme A and adenosine 3',5'-diphosphate in human mitochondria. J Biol Chem. 2009 Jul 3;284(27):18152-9. DM1I8LU RU http://www.ncbi.nlm.nih.gov/pubmed/19429682 DM1I8LU DI DM1I8LU DM1I8LU DN Coenzyme A DM1I8LU MI DTYR5U7 DM1I8LU MN Peroxisomal membrane protein PMP34 (SLC25A17) DM1I8LU MT DTP DM1I8LU MA Substrate DM1I8LU RN The human gene SLC25A17 encodes a peroxisomal transporter of coenzyme A, FAD and NAD+. Biochem J. 2012 Apr 1;443(1):241-7. DM1I8LU RU http://www.ncbi.nlm.nih.gov/pubmed/22185573 DM1I8LU DI DM1I8LU DM1I8LU DN Coenzyme A DM1I8LU MI TT4YO0Z DM1I8LU MN Phosphopantetheine adenylyltransferase (PPAT) DM1I8LU MT DTT DM1I8LU MA Inhibitor DM1I8LU RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DM1I8LU RU https://pubmed.ncbi.nlm.nih.gov/17139284 DM1I8LU DI DM1I8LU DM1I8LU DN Coenzyme A DM1I8LU MI TT8HWCD DM1I8LU MN Staphylococcus DHNA-CoA synthase (Stap-coc menB) DM1I8LU MT DTT DM1I8LU MA Inhibitor DM1I8LU RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DM1I8LU RU https://pubmed.ncbi.nlm.nih.gov/17139284 DM0ACL9 DI DM0ACL9 DM0ACL9 DN Coformycin DM0ACL9 MI TTKZ09F DM0ACL9 MN Adenosine monophosphate deaminase (AMPD) DM0ACL9 MT DTT DM0ACL9 MA Inhibitor DM0ACL9 RN Mechanisms of cell death induced by 2-chloroadenosine in leukemic B-cells. Biochem Pharmacol. 2008 Apr 1;75(7):1451-60. DM0ACL9 RU https://pubmed.ncbi.nlm.nih.gov/18242582 DM326VN DI DM326VN DM326VN DN COLCHINOL DM326VN MI TTML2WA DM326VN MN Tubulin (TUB) DM326VN MT DTT DM326VN MA Inhibitor DM326VN RN Synthesis and structure-activity relationships of 1,2,4-triazoles as a novel class of potent tubulin polymerization inhibitors. Bioorg Med Chem Lett. 2005 Dec 1;15(23):5154-9. DM326VN RU https://pubmed.ncbi.nlm.nih.gov/16198562 DM326VN DI DM326VN DM326VN DN COLCHINOL DM326VN MI TTYFKSZ DM326VN MN Tubulin beta (TUBB) DM326VN MT DTT DM326VN MA Inhibitor DM326VN RN Synthesis and structure-activity relationships of 1,2,4-triazoles as a novel class of potent tubulin polymerization inhibitors. Bioorg Med Chem Lett. 2005 Dec 1;15(23):5154-9. DM326VN RU https://pubmed.ncbi.nlm.nih.gov/16198562 DMIKD8X DI DMIKD8X DMIKD8X DN COMBETASTATIN DMIKD8X MI TTML2WA DMIKD8X MN Tubulin (TUB) DMIKD8X MT DTT DMIKD8X MA Inhibitor DMIKD8X RN Asymmetric synthesis of antimitotic combretadioxolane with potent antitumor activity against multi-drug resistant cells. Bioorg Med Chem Lett. 1998 Aug 4;8(15):1997-2000. DMIKD8X RU https://pubmed.ncbi.nlm.nih.gov/9873473 DMIKD8X DI DMIKD8X DMIKD8X DN COMBETASTATIN DMIKD8X MI TTYFKSZ DMIKD8X MN Tubulin beta (TUBB) DMIKD8X MT DTT DMIKD8X MA Inhibitor DMIKD8X RN Asymmetric synthesis of antimitotic combretadioxolane with potent antitumor activity against multi-drug resistant cells. Bioorg Med Chem Lett. 1998 Aug 4;8(15):1997-2000. DMIKD8X RU https://pubmed.ncbi.nlm.nih.gov/9873473 DMC2IYH DI DMC2IYH DMC2IYH DN Conantokin-G DMC2IYH MI TTN9D8E DMC2IYH MN Glutamate receptor ionotropic NMDA 2B (NMDAR2B) DMC2IYH MT DTT DMC2IYH MA Inhibitor DMC2IYH RN Novel conantokins from Conus parius venom are specific antagonists of N-methyl-D-aspartate receptors. J Biol Chem. 2007 Dec 21;282(51):36905-13. DMC2IYH RU https://pubmed.ncbi.nlm.nih.gov/17962189 DMN4KJI DI DMN4KJI DMN4KJI DN Conantokin-R DMN4KJI MI TTKJEMQ DMN4KJI MN Glutamate receptor ionotropic NMDA 2A (NMDAR2A) DMN4KJI MT DTT DMN4KJI MA Inhibitor DMN4KJI RN Novel conantokins from Conus parius venom are specific antagonists of N-methyl-D-aspartate receptors. J Biol Chem. 2007 Dec 21;282(51):36905-13. DMN4KJI RU https://pubmed.ncbi.nlm.nih.gov/17962189 DMN4KJI DI DMN4KJI DMN4KJI DN Conantokin-R DMN4KJI MI TTN9D8E DMN4KJI MN Glutamate receptor ionotropic NMDA 2B (NMDAR2B) DMN4KJI MT DTT DMN4KJI MA Inhibitor DMN4KJI RN Novel conantokins from Conus parius venom are specific antagonists of N-methyl-D-aspartate receptors. J Biol Chem. 2007 Dec 21;282(51):36905-13. DMN4KJI RU https://pubmed.ncbi.nlm.nih.gov/17962189 DMLHF3E DI DMLHF3E DMLHF3E DN Conantokins G DMLHF3E MI TTN9D8E DMLHF3E MN Glutamate receptor ionotropic NMDA 2B (NMDAR2B) DMLHF3E MT DTT DMLHF3E MA Antagonist DMLHF3E RN Powerful antinociceptive effects of the cone snail venom-derived subtype-selective NMDA receptor antagonists conantokins G and T. Pain. 2003 Jan;101(1-2):109-16. DMLHF3E RU https://pubmed.ncbi.nlm.nih.gov/12507705 DMV6H5S DI DMV6H5S DMV6H5S DN Conantokins T DMV6H5S MI TTN9D8E DMV6H5S MN Glutamate receptor ionotropic NMDA 2B (NMDAR2B) DMV6H5S MT DTT DMV6H5S MA Antagonist DMV6H5S RN Powerful antinociceptive effects of the cone snail venom-derived subtype-selective NMDA receptor antagonists conantokins G and T. Pain. 2003 Jan;101(1-2):109-16. DMV6H5S RU https://pubmed.ncbi.nlm.nih.gov/12507705 DMC5RKY DI DMC5RKY DMC5RKY DN Concatameric CTLA4Ig DMC5RKY MI TTI2S1D DMC5RKY MN Cytotoxic T-lymphocyte protein 4 (CTLA-4) DMC5RKY MT DTT DMC5RKY MA Modulator DMC5RKY RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2743). DMC5RKY RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2743 DMRPV0A DI DMRPV0A DMRPV0A DN Concatameric LAG3Ig DMRPV0A MI TTNVXAW DMRPV0A MN Lymphocyte activation gene 3 protein (LAG3) DMRPV0A MT DTT DMRPV0A MA Modulator DMRPV0A RN IMP321 (sLAG-3), an immunopotentiator for T cell responses against a HBsAg antigen in healthy adults: a single blind randomised controlled phase I study. J Immune Based Ther Vaccines. 2007 Mar 29;5:5. DMRPV0A RU https://pubmed.ncbi.nlm.nih.gov/17394654 DM4VYP0 DI DM4VYP0 DM4VYP0 DN CONESSINE DM4VYP0 MI TT2NUT5 DM4VYP0 MN Adrenergic receptor alpha-2C (ADRA2C) DM4VYP0 MT DTT DM4VYP0 MA Inhibitor DM4VYP0 RN The alkaloid conessine and analogues as potent histamine H3 receptor antagonists. J Med Chem. 2008 Sep 11;51(17):5423-30. DM4VYP0 RU https://pubmed.ncbi.nlm.nih.gov/18683917 DM4VYP0 DI DM4VYP0 DM4VYP0 DN CONESSINE DM4VYP0 MI TT9JNIC DM4VYP0 MN Histamine H3 receptor (H3R) DM4VYP0 MT DTT DM4VYP0 MA Inhibitor DM4VYP0 RN Design of a new histamine H3 receptor antagonist chemotype: (3aR,6aR)-5-alkyl-1-aryl-octahydropyrrolo[3,4-b]pyrroles, synthesis, and structure-acti... J Med Chem. 2009 Aug 13;52(15):4640-9. DM4VYP0 RU https://pubmed.ncbi.nlm.nih.gov/19588934 DM4VYP0 DI DM4VYP0 DM4VYP0 DN CONESSINE DM4VYP0 MI TTRTKPV DM4VYP0 MN Trypanosoma Trypanothione reductase (Trypano TPR) DM4VYP0 MT DTT DM4VYP0 MA Inhibitor DM4VYP0 RN The use of natural product scaffolds as leads in the search for trypanothione reductase inhibitors. Bioorg Med Chem. 2008 Jul 15;16(14):6689-95. DM4VYP0 RU https://pubmed.ncbi.nlm.nih.gov/18558492 DMQG2MC DI DMQG2MC DMQG2MC DN Conotoxin DMQG2MC MI TT4FDG6 DMQG2MC MN Voltage-gated calcium channel alpha Cav2.2 (CACNA1B) DMQG2MC MT DTT DMQG2MC MA Blocker DMQG2MC RN Treatment with conotoxin, an 'N-type' calcium channel blocker, in neuronal hypoxic-ischemic injury. Brain Res. 1990 Dec 24;537(1-2):256-62. DMQG2MC RU https://pubmed.ncbi.nlm.nih.gov/2085777 DM5DTZR DI DM5DTZR DM5DTZR DN COOH DM5DTZR MI TTT2SVW DM5DTZR MN PPAR-gamma messenger RNA (PPARG mRNA) DM5DTZR MT DTT DM5DTZR MA Agonist DM5DTZR RN PPAR-gamma activation mediates adipose depot-specific effects on gene expression and lipoprotein lipase activity: mechanisms for modulation of postprandial lipemia and differential adipose accretion.Diabetes. 2003 Feb;52(2):291-9. DM5DTZR RU https://pubmed.ncbi.nlm.nih.gov/12540599 DMFH5J9 DI DMFH5J9 DMFH5J9 DN cooling agent 10 DMFH5J9 MI TTXDKTO DMFH5J9 MN Long transient receptor potential channel 8 (TRPM8) DMFH5J9 MT DTT DMFH5J9 MA Activator DMFH5J9 RN Characterization of the mouse cold-menthol receptor TRPM8 and vanilloid receptor type-1 VR1 using a fluorometric imaging plate reader (FLIPR) assay. Br J Pharmacol. 2004 Feb;141(4):737-45. DMFH5J9 RU https://pubmed.ncbi.nlm.nih.gov/14757700 DMT5SED DI DMT5SED DMT5SED DN CORDOIN DMT5SED MI TTGP7BY DMT5SED MN Monoamine oxidase type B (MAO-B) DMT5SED MT DTT DMT5SED MA Inhibitor DMT5SED RN Chalcones: a valid scaffold for monoamine oxidases inhibitors. J Med Chem. 2009 May 14;52(9):2818-24. DMT5SED RU https://pubmed.ncbi.nlm.nih.gov/19378991 DM72Y01 DI DM72Y01 DM72Y01 DN Cordycepin DM72Y01 MI DTZAWTH DM72Y01 MN Equilibrative nucleoside transporter 3 (SLC29A3) DM72Y01 MT DTP DM72Y01 MA Substrate DM72Y01 RN Functional characterization of novel human and mouse equilibrative nucleoside transporters (hENT3 and mENT3) located in intracellular membranes. J Biol Chem. 2005 Apr 22;280(16):15880-7. DM72Y01 RU http://www.ncbi.nlm.nih.gov/pubmed/15701636 DMAC698 DI DMAC698 DMAC698 DN CORILAGIN DMAC698 MI TT84ETX DMAC698 MN Human immunodeficiency virus Reverse transcriptase (HIV RT) DMAC698 MT DTT DMAC698 MA Inhibitor DMAC698 RN HIV and reverse transcriptase inhibition by tanninsOriginal Research. Bioorg. Med. Chem. Lett. 2(12):1529-1534 (1992). DMAC698 RU http://www.sciencedirect.com/science/article/pii/S0960894X00804229 DMAC698 DI DMAC698 DMAC698 DN CORILAGIN DMAC698 MI TTE14XG DMAC698 MN Squalene monooxygenase (SQLE) DMAC698 MT DTT DMAC698 MA Inhibitor DMAC698 RN Ellagitannins and hexahydroxydiphenoyl esters as inhibitors of vertebrate squalene epoxidase. J Nat Prod. 2001 Aug;64(8):1010-4. DMAC698 RU https://pubmed.ncbi.nlm.nih.gov/11520216 DMZBUE7 DI DMZBUE7 DMZBUE7 DN CORONARIDINE DMZBUE7 MI TT1RS9F DMZBUE7 MN Acetylcholinesterase (AChE) DMZBUE7 MT DTT DMZBUE7 MA Inhibitor DMZBUE7 RN Indole alkaloids from Ervatamia hainanensis with potent acetylcholinesterase inhibition activities. Bioorg Med Chem Lett. 2010 Nov 1;20(21):6185-7. DMZBUE7 RU https://pubmed.ncbi.nlm.nih.gov/20850311 DM563PZ DI DM563PZ DM563PZ DN Corosolic acid DM563PZ MI TTN7BL9 DM563PZ MN Corticosteroid 11-beta-dehydrogenase 1 (HSD11B1) DM563PZ MT DTT DM563PZ MA Inhibitor DM563PZ RN 11beta-Hydroxysteroid dehydrogenase 1 inhibiting constituents from Eriobotrya japonica revealed by bioactivity-guided isolation and computational a... Bioorg Med Chem. 2010 Feb 15;18(4):1507-15. DM563PZ RU https://pubmed.ncbi.nlm.nih.gov/20100662 DM5ISQK DI DM5ISQK DM5ISQK DN Correloid DM5ISQK MI TTY3UE6 DM5ISQK MN Voltage-gated potassium channel Kv1.3 (KCNA3) DM5ISQK MT DTT DM5ISQK MA Inhibitor DM5ISQK RN Potent Kv1.3 inhibitors from correolide-modification of the C18 position. Bioorg Med Chem Lett. 2005 Jan 17;15(2):447-51. DM5ISQK RU https://pubmed.ncbi.nlm.nih.gov/15603971 DMACH7K DI DMACH7K DMACH7K DN correolide DMACH7K MI TTY3UE6 DMACH7K MN Voltage-gated potassium channel Kv1.3 (KCNA3) DMACH7K MT DTT DMACH7K MA Blocker (channel blocker) DMACH7K RN Identification and biochemical characterization of a novel nortriterpene inhibitor of the human lymphocyte voltage-gated potassium channel, Kv1.3. Biochemistry. 1999 Apr 20;38(16):4922-30. DMACH7K RU https://pubmed.ncbi.nlm.nih.gov/10213593 DM463S2 DI DM463S2 DM463S2 DN CORYMBONE B DM463S2 MI TT4J8MF DM463S2 MN Thyrotropin-releasing hormone receptor (TRHR) DM463S2 MT DTT DM463S2 MA Inhibitor DM463S2 RN Corymbones A and B, phloroglucinols with thyrotropin releasing hormone receptor 2 binding affinity from the flowers of Corymbia peltata. J Nat Prod. 2008 May;71(5):881-3. DM463S2 RU https://pubmed.ncbi.nlm.nih.gov/18412395 DM18CUZ DI DM18CUZ DM18CUZ DN CORYNANTHEINE DM18CUZ MI TTNGILX DM18CUZ MN Adrenergic receptor alpha-1A (ADRA1A) DM18CUZ MT DTT DM18CUZ MA Inhibitor DM18CUZ RN Pharmacophore identification of alpha(1A)-adrenoceptor antagonists. Bioorg Med Chem Lett. 2005 Feb 1;15(3):657-64. DM18CUZ RU https://pubmed.ncbi.nlm.nih.gov/15664832 DM18CUZ DI DM18CUZ DM18CUZ DN CORYNANTHEINE DM18CUZ MI TTBRKXS DM18CUZ MN Adrenergic receptor alpha-1B (ADRA1B) DM18CUZ MT DTT DM18CUZ MA Inhibitor DM18CUZ RN Alpha- and beta-adrenoceptors: from the gene to the clinic. 2. Structure-activity relationships and therapeutic applications. J Med Chem. 1995 Sep 15;38(19):3681-716. DM18CUZ RU https://pubmed.ncbi.nlm.nih.gov/7562902 DM18CUZ DI DM18CUZ DM18CUZ DN CORYNANTHEINE DM18CUZ MI TT34BHT DM18CUZ MN Adrenergic receptor alpha-1D (ADRA1D) DM18CUZ MT DTT DM18CUZ MA Inhibitor DM18CUZ RN Alpha- and beta-adrenoceptors: from the gene to the clinic. 2. Structure-activity relationships and therapeutic applications. J Med Chem. 1995 Sep 15;38(19):3681-716. DM18CUZ RU https://pubmed.ncbi.nlm.nih.gov/7562902 DM18CUZ DI DM18CUZ DM18CUZ DN CORYNANTHEINE DM18CUZ MI TTZIFHC DM18CUZ MN Voltage-gated calcium channel alpha Cav1.2 (CACNA1C) DM18CUZ MT DTT DM18CUZ MA Inhibitor DM18CUZ RN Alpha- and beta-adrenoceptors: from the gene to the clinic. 2. Structure-activity relationships and therapeutic applications. J Med Chem. 1995 Sep 15;38(19):3681-716. DM18CUZ RU https://pubmed.ncbi.nlm.nih.gov/7562902 DMSFXJ8 DI DMSFXJ8 DMSFXJ8 DN Cosalane derivative DMSFXJ8 MI TTC24WT DMSFXJ8 MN C-C chemokine receptor type 1 (CCR1) DMSFXJ8 MT DTT DMSFXJ8 MA Inhibitor DMSFXJ8 RN Inhibition of RANTES/CCR1-mediated chemotaxis by cosalane and related compounds. Bioorg Med Chem Lett. 2001 Jan 8;11(1):59-62. DMSFXJ8 RU https://pubmed.ncbi.nlm.nih.gov/11140734 DMU6OB4 DI DMU6OB4 DMU6OB4 DN Costunolide DMU6OB4 MI TT1EDJZ DMU6OB4 MN Microtubule-associated protein (MAP) DMU6OB4 MT DTT DMU6OB4 MA Binder DMU6OB4 RN A sesquiterpene lactone, costunolide, interacts with microtubule protein and inhibits the growth of MCF-7 cells. Chem Biol Interact. 2004 Jan 15;147(1):79-86. DMU6OB4 RU https://pubmed.ncbi.nlm.nih.gov/14726154 DM7TCPG DI DM7TCPG DM7TCPG DN Coumaranone DM7TCPG MI DESDN74 DM7TCPG MN Serum paraoxonase/arylesterase 1 (PON1) DM7TCPG MT DME DM7TCPG MA Metabolism DM7TCPG RN Human serum paraoxonase (PON1) isozymes Q and R hydrolyze lactones and cyclic carbonate esters. Drug Metab Dispos. 2000 Nov;28(11):1335-42. DM7TCPG RU https://www.ncbi.nlm.nih.gov/pubmed/?term=11038162 DM0N8ZM DI DM0N8ZM DM0N8ZM DN Coumarin DM0N8ZM MI TTUNARX DM0N8ZM MN Carbonic anhydrase (CA) DM0N8ZM MT DTT DM0N8ZM MA Inhibitor DM0N8ZM RN Deciphering the mechanism of carbonic anhydrase inhibition with coumarins and thiocoumarins. J Med Chem. 2010 Jan 14;53(1):335-44. DM0N8ZM RU https://pubmed.ncbi.nlm.nih.gov/19911821 DM0N8ZM DI DM0N8ZM DM0N8ZM DN Coumarin DM0N8ZM MI TTHQPL7 DM0N8ZM MN Carbonic anhydrase I (CA-I) DM0N8ZM MT DTT DM0N8ZM MA Inhibitor DM0N8ZM RN 7,8-disubstituted- but not 6,7-disubstituted coumarins selectively inhibit the transmembrane, tumor-associated carbonic anhydrase isoforms IX and X... Bioorg Med Chem Lett. 2010 Dec 15;20(24):7255-8. DM0N8ZM RU https://pubmed.ncbi.nlm.nih.gov/21067924 DM0N8ZM DI DM0N8ZM DM0N8ZM DN Coumarin DM0N8ZM MI TTANPDJ DM0N8ZM MN Carbonic anhydrase II (CA-II) DM0N8ZM MT DTT DM0N8ZM MA Inhibitor DM0N8ZM RN 7,8-disubstituted- but not 6,7-disubstituted coumarins selectively inhibit the transmembrane, tumor-associated carbonic anhydrase isoforms IX and X... Bioorg Med Chem Lett. 2010 Dec 15;20(24):7255-8. DM0N8ZM RU https://pubmed.ncbi.nlm.nih.gov/21067924 DM0N8ZM DI DM0N8ZM DM0N8ZM DN Coumarin DM0N8ZM MI TTZHA0O DM0N8ZM MN Carbonic anhydrase IV (CA-IV) DM0N8ZM MT DTT DM0N8ZM MA Inhibitor DM0N8ZM RN Deciphering the mechanism of carbonic anhydrase inhibition with coumarins and thiocoumarins. J Med Chem. 2010 Jan 14;53(1):335-44. DM0N8ZM RU https://pubmed.ncbi.nlm.nih.gov/19911821 DM0N8ZM DI DM0N8ZM DM0N8ZM DN Coumarin DM0N8ZM MI TT2LVK8 DM0N8ZM MN Carbonic anhydrase IX (CA-IX) DM0N8ZM MT DTT DM0N8ZM MA Inhibitor DM0N8ZM RN Deciphering the mechanism of carbonic anhydrase inhibition with coumarins and thiocoumarins. J Med Chem. 2010 Jan 14;53(1):335-44. DM0N8ZM RU https://pubmed.ncbi.nlm.nih.gov/19911821 DM0N8ZM DI DM0N8ZM DM0N8ZM DN Coumarin DM0N8ZM MI TTCFSPE DM0N8ZM MN Carbonic anhydrase VI (CA-VI) DM0N8ZM MT DTT DM0N8ZM MA Inhibitor DM0N8ZM RN Deciphering the mechanism of carbonic anhydrase inhibition with coumarins and thiocoumarins. J Med Chem. 2010 Jan 14;53(1):335-44. DM0N8ZM RU https://pubmed.ncbi.nlm.nih.gov/19911821 DM0N8ZM DI DM0N8ZM DM0N8ZM DN Coumarin DM0N8ZM MI TTSYM0R DM0N8ZM MN Carbonic anhydrase XII (CA-XII) DM0N8ZM MT DTT DM0N8ZM MA Inhibitor DM0N8ZM RN Deciphering the mechanism of carbonic anhydrase inhibition with coumarins and thiocoumarins. J Med Chem. 2010 Jan 14;53(1):335-44. DM0N8ZM RU https://pubmed.ncbi.nlm.nih.gov/19911821 DM0N8ZM DI DM0N8ZM DM0N8ZM DN Coumarin DM0N8ZM MI TTEYTKG DM0N8ZM MN Carbonic anhydrase XIV (CA-XIV) DM0N8ZM MT DTT DM0N8ZM MA Inhibitor DM0N8ZM RN Deciphering the mechanism of carbonic anhydrase inhibition with coumarins and thiocoumarins. J Med Chem. 2010 Jan 14;53(1):335-44. DM0N8ZM RU https://pubmed.ncbi.nlm.nih.gov/19911821 DM0N8ZM DI DM0N8ZM DM0N8ZM DN Coumarin DM0N8ZM MI DEUWAV0 DM0N8ZM MN Cytochrome P450 102D1 (cyp102) DM0N8ZM MT DME DM0N8ZM MA Metabolism DM0N8ZM RN The metagenome of Caracolus marginella gut microbiome using culture independent approaches and shotgun sequencing. Data Brief. 2017 Nov 22;16:501-505. DM0N8ZM RU https://pubmed.ncbi.nlm.nih.gov/29270447 DM0N8ZM DI DM0N8ZM DM0N8ZM DN Coumarin DM0N8ZM MI DE5IED8 DM0N8ZM MN Cytochrome P450 2C9 (CYP2C9) DM0N8ZM MT DME DM0N8ZM MA Metabolism DM0N8ZM RN Pharmacogenomics of CYP2C9: functional and clinical considerations. J Pers Med. 2017 Dec 28;8(1). DM0N8ZM RU https://www.ncbi.nlm.nih.gov/pubmed/?term=29283396 DMAJNPS DI DMAJNPS DMAJNPS DN Coumermycin DMAJNPS MI TTS7LWX DMAJNPS MN Bacterial DNA gyrase B (Bact gyrB) DMAJNPS MT DTT DMAJNPS MA Inhibitor DMAJNPS RN Isolation and characterization of an Escherichia coli strain exhibiting partial tolerance to quinolones. Antimicrob Agents Chemother. 1989 May;33(5):705-9. DMAJNPS RU https://pubmed.ncbi.nlm.nih.gov/2665642 DM40TBU DI DM40TBU DM40TBU DN Coumestrol DM40TBU MI DTI7UX6 DM40TBU MN Breast cancer resistance protein (ABCG2) DM40TBU MT DTP DM40TBU MA Substrate DM40TBU RN Effect of breast cancer resistance protein (Bcrp/Abcg2) on the disposition of phytoestrogens. Mol Pharmacol. 2007 Oct;72(4):967-75. DM40TBU RU https://doi.org/10.1124/mol.107.034751 DM40TBU DI DM40TBU DM40TBU DN Coumestrol DM40TBU MI TTZAYWL DM40TBU MN Estrogen receptor (ESR) DM40TBU MT DTT DM40TBU MA Inhibitor DM40TBU RN Structure-based virtual screening for plant-based ERbeta-selective ligands as potential preventative therapy against age-related neurodegenerative ... J Med Chem. 2005 May 19;48(10):3463-6. DM40TBU RU https://pubmed.ncbi.nlm.nih.gov/15887952 DM40TBU DI DM40TBU DM40TBU DN Coumestrol DM40TBU MI TTOM3J0 DM40TBU MN Estrogen receptor beta (ESR2) DM40TBU MT DTT DM40TBU MA Inhibitor DM40TBU RN Structure-based virtual screening for plant-based ERbeta-selective ligands as potential preventative therapy against age-related neurodegenerative ... J Med Chem. 2005 May 19;48(10):3463-6. DM40TBU RU https://pubmed.ncbi.nlm.nih.gov/15887952 DM2LWNF DI DM2LWNF DM2LWNF DN COV08-0064 DM2LWNF MI TTSHG0T DM2LWNF MN Toll-like receptor 9 (TLR9) DM2LWNF MT DTT DM2LWNF MA Agonist DM2LWNF RN The novel TLR9 antagonist COV08-0064 protects from ischemia/reperfusion injury in non-steatotic and steatotic mice livers. Biochem Pharmacol. 2016 Jul 15;112:90-101. DM2LWNF RU https://pubmed.ncbi.nlm.nih.gov/27157410 DMT2RHV DI DMT2RHV DMT2RHV DN CP 4010 DMT2RHV MI TT51ZGC DMT2RHV MN Herpes simplex virus DNA polymerase POL (HSV POL) DMT2RHV MT DTT DMT2RHV MA Modulator DMT2RHV RN Herpes simplex virus type 1 DNA polymerase. Mechanism of inhibition by acyclovir triphosphate. J Biol Chem. 1989 May 5;264(13):7405-11. DMT2RHV RU https://pubmed.ncbi.nlm.nih.gov/2540193 DMSNVKP DI DMSNVKP DMSNVKP DN CP 93129 DMSNVKP MI TTSQIFT DMSNVKP MN 5-HT 1A receptor (HTR1A) DMSNVKP MT DTT DMSNVKP MA Agonist DMSNVKP RN Agonist activity of antimigraine drugs at recombinant human 5-HT1A receptors: potential implications for prophylactic and acute therapy. Naunyn Schmiedebergs Arch Pharmacol. 1997 Jun;355(6):682-8. DMSNVKP RU https://pubmed.ncbi.nlm.nih.gov/9205951 DMLFNTH DI DMLFNTH DMLFNTH DN CP-100263 DMLFNTH MI TTZPO1L DMLFNTH MN Substance-P receptor (TACR1) DMLFNTH MT DTT DMLFNTH MA Antagonist DMLFNTH RN Emerging drugs for chemotherapy-induced emesis. Expert Opin Emerg Drugs. 2006 Mar;11(1):137-51. DMLFNTH RU https://pubmed.ncbi.nlm.nih.gov/16503832 DM3ZIDT DI DM3ZIDT DM3ZIDT DN CP-126998 DM3ZIDT MI TT1RS9F DM3ZIDT MN Acetylcholinesterase (AChE) DM3ZIDT MT DTT DM3ZIDT MA Modulator DM3ZIDT RN PET imaging of brain acetylcholinesterase using [11C]CP-126,998, a brain selective enzyme inhibitor. Synapse. 2002 Jul;45(1):1-9. DM3ZIDT RU https://www.ncbi.nlm.nih.gov/pubmed/12112408 DMYHR74 DI DMYHR74 DMYHR74 DN CP154,526 DMYHR74 MI TT7EFHR DMYHR74 MN Corticotropin-releasing factor receptor 1 (CRHR1) DMYHR74 MT DTT DMYHR74 MA Antagonist DMYHR74 RN A review of drug options in age-related macular degeneration therapy and potential new agents. Expert Opin Pharmacother. 2006 Dec;7(17):2355-68. DMYHR74 RU https://pubmed.ncbi.nlm.nih.gov/17109611 DMGLO2X DI DMGLO2X DMGLO2X DN CP-226269 DMGLO2X MI TTE0A2F DMGLO2X MN Dopamine D4 receptor (D4R) DMGLO2X MT DTT DMGLO2X MA Agonist DMGLO2X RN Certain 1,4-disubstituted aromatic piperidines and piperazines with extreme selectivity for the dopamine D4 receptor interact with a common recepto... Mol Pharmacol. 2004 Dec;66(6):1491-9. DMGLO2X RU https://pubmed.ncbi.nlm.nih.gov/15448188 DMGN38F DI DMGN38F DMGN38F DN CP-271485 DMGN38F MI TTXZ0KQ DMGN38F MN Matrix metalloproteinase-12 (MMP-12) DMGN38F MT DTT DMGN38F MA Inhibitor DMGN38F RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMGN38F RU https://pubmed.ncbi.nlm.nih.gov/17139284 DM6BRLA DI DM6BRLA DM6BRLA DN CP-294838 DM6BRLA MI TTFQEO5 DM6BRLA MN Squalene synthetase (FDFT1) DM6BRLA MT DTT DM6BRLA MA Inhibitor DM6BRLA RN Truncation of human squalene synthase yields active, crystallizable protein. Arch Biochem Biophys. 1998 Feb 15;350(2):283-90. DM6BRLA RU https://pubmed.ncbi.nlm.nih.gov/9473303 DMME6K2 DI DMME6K2 DMME6K2 DN CP-305202 DMME6K2 MI TTB2MXP DMME6K2 MN Angiotensinogenase renin (REN) DMME6K2 MT DTT DMME6K2 MA Inhibitor DMME6K2 RN Direct renin inhibitors as a new therapy for hypertension. J Med Chem. 2010 Nov 11;53(21):7490-520. DMME6K2 RU https://pubmed.ncbi.nlm.nih.gov/20731374 DMY8O0B DI DMY8O0B DMY8O0B DN CP-320626 DMY8O0B MI TTTSOUD DMY8O0B MN Candida Cytochrome P450 51 (Candi ERG11) DMY8O0B MT DTT DMY8O0B MA Inhibitor DMY8O0B RN Three-dimensional quantitative structure-activity relationship analysis of human CYP51 inhibitors. Drug Metab Dispos. 2007 Mar;35(3):493-500. DMY8O0B RU https://pubmed.ncbi.nlm.nih.gov/17194716 DMTJOWH DI DMTJOWH DMTJOWH DN CP-339818 DMTJOWH MI TTY3UE6 DMTJOWH MN Voltage-gated potassium channel Kv1.3 (KCNA3) DMTJOWH MT DTT DMTJOWH MA Inhibitor DMTJOWH RN Angular methoxy-substituted furo- and pyranoquinolinones as blockers of the voltage-gated potassium channel Kv1.3. J Med Chem. 2001 Apr 12;44(8):1249-56. DMTJOWH RU https://pubmed.ncbi.nlm.nih.gov/11312924 DM93CA4 DI DM93CA4 DM93CA4 DN CP-376395 DM93CA4 MI TT7EFHR DM93CA4 MN Corticotropin-releasing factor receptor 1 (CRHR1) DM93CA4 MT DTT DM93CA4 MA Inhibitor DM93CA4 RN 2-aryloxy-4-alkylaminopyridines: discovery of novel corticotropin-releasing factor 1 antagonists. J Med Chem. 2008 Mar 13;51(5):1385-92. DM93CA4 RU https://pubmed.ncbi.nlm.nih.gov/18288792 DMDPH3W DI DMDPH3W DMDPH3W DN CP-394531 DMDPH3W MI TTKPW01 DMDPH3W MN Androgen receptor messenger RNA (AR mRNA) DMDPH3W MT DTT DMDPH3W MA Inhibitor DMDPH3W RN Discovery of potent, nonsteroidal, and highly selective glucocorticoid receptor antagonists. J Med Chem. 2002 Jun 6;45(12):2417-24. DMDPH3W RU https://pubmed.ncbi.nlm.nih.gov/12036351 DMDPH3W DI DMDPH3W DMDPH3W DN CP-394531 DMDPH3W MI TTZAYWL DMDPH3W MN Estrogen receptor (ESR) DMDPH3W MT DTT DMDPH3W MA Inhibitor DMDPH3W RN Discovery of potent, nonsteroidal, and highly selective glucocorticoid receptor antagonists. J Med Chem. 2002 Jun 6;45(12):2417-24. DMDPH3W RU https://pubmed.ncbi.nlm.nih.gov/12036351 DMDPH3W DI DMDPH3W DMDPH3W DN CP-394531 DMDPH3W MI TTOM3J0 DMDPH3W MN Estrogen receptor beta (ESR2) DMDPH3W MT DTT DMDPH3W MA Inhibitor DMDPH3W RN Discovery of potent, nonsteroidal, and highly selective glucocorticoid receptor antagonists. J Med Chem. 2002 Jun 6;45(12):2417-24. DMDPH3W RU https://pubmed.ncbi.nlm.nih.gov/12036351 DMDPH3W DI DMDPH3W DMDPH3W DN CP-394531 DMDPH3W MI TTOZRK6 DMDPH3W MN Glucocorticoid receptor messenger RNA (GCR mRNA) DMDPH3W MT DTT DMDPH3W MA Inhibitor DMDPH3W RN Virtual screening for the identification of novel nonsteroidal glucocorticoid modulators. J Med Chem. 2010 Apr 22;53(8):3065-74. DMDPH3W RU https://pubmed.ncbi.nlm.nih.gov/20334371 DM1U6P7 DI DM1U6P7 DM1U6P7 DN CP-409069 DM1U6P7 MI TTKPW01 DM1U6P7 MN Androgen receptor messenger RNA (AR mRNA) DM1U6P7 MT DTT DM1U6P7 MA Inhibitor DM1U6P7 RN Discovery of potent, nonsteroidal, and highly selective glucocorticoid receptor antagonists. J Med Chem. 2002 Jun 6;45(12):2417-24. DM1U6P7 RU https://pubmed.ncbi.nlm.nih.gov/12036351 DM1U6P7 DI DM1U6P7 DM1U6P7 DN CP-409069 DM1U6P7 MI TTZAYWL DM1U6P7 MN Estrogen receptor (ESR) DM1U6P7 MT DTT DM1U6P7 MA Inhibitor DM1U6P7 RN Discovery of potent, nonsteroidal, and highly selective glucocorticoid receptor antagonists. J Med Chem. 2002 Jun 6;45(12):2417-24. DM1U6P7 RU https://pubmed.ncbi.nlm.nih.gov/12036351 DM1U6P7 DI DM1U6P7 DM1U6P7 DN CP-409069 DM1U6P7 MI TTOM3J0 DM1U6P7 MN Estrogen receptor beta (ESR2) DM1U6P7 MT DTT DM1U6P7 MA Inhibitor DM1U6P7 RN Discovery of potent, nonsteroidal, and highly selective glucocorticoid receptor antagonists. J Med Chem. 2002 Jun 6;45(12):2417-24. DM1U6P7 RU https://pubmed.ncbi.nlm.nih.gov/12036351 DM1U6P7 DI DM1U6P7 DM1U6P7 DN CP-409069 DM1U6P7 MI TTOZRK6 DM1U6P7 MN Glucocorticoid receptor messenger RNA (GCR mRNA) DM1U6P7 MT DTT DM1U6P7 MA Inhibitor DM1U6P7 RN Virtual screening for the identification of novel nonsteroidal glucocorticoid modulators. J Med Chem. 2010 Apr 22;53(8):3065-74. DM1U6P7 RU https://pubmed.ncbi.nlm.nih.gov/20334371 DMROYD7 DI DMROYD7 DMROYD7 DN CP-409092 DMROYD7 MI TTEX6LM DMROYD7 MN GABA(A) receptor gamma-3 (GABRG3) DMROYD7 MT DTT DMROYD7 MA Modulator DMROYD7 RN The ChEMBL database in 2017. Nucleic Acids Res. 2017 Jan 4;45(D1):D945-D954. DMROYD7 RU https://www.ncbi.nlm.nih.gov/pubmed/27899562 DMZMKAQ DI DMZMKAQ DMZMKAQ DN CP-4200 DMZMKAQ MI TT6S2FE DMZMKAQ MN DNA [cytosine-5]-methyltransferase 1 (DNMT1) DMZMKAQ MT DTT DMZMKAQ MA Inhibitor DMZMKAQ RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2605). DMZMKAQ RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2605 DMTHVCA DI DMTHVCA DMTHVCA DN CP-4497 DMTHVCA MI TT6OEDT DMTHVCA MN Cannabinoid receptor 1 (CB1) DMTHVCA MT DTT DMTHVCA MA Inhibitor DMTHVCA RN Synthesis and pharmacology of 1-methoxy analogs of CP-47,497. Bioorg Med Chem. 2010 Aug 1;18(15):5475-82. DMTHVCA RU https://pubmed.ncbi.nlm.nih.gov/20621488 DMS2RHE DI DMS2RHE DMS2RHE DN CP-470,711 DMS2RHE MI TTLSRBZ DMS2RHE MN Sorbitoldehydrogenase (SORD) DMS2RHE MT DTT DMS2RHE MA Inhibitor DMS2RHE RN Sorbitol dehydrogenase: a novel target for adjunctive protection of ischemic myocardium. FASEB J. 2003 Dec;17(15):2331-3. DMS2RHE RU https://pubmed.ncbi.nlm.nih.gov/14525943 DMZT7C1 DI DMZT7C1 DMZT7C1 DN CP-481,715 DMZT7C1 MI TT8KLPT DMZT7C1 MN C-C chemokine receptor (CCR) DMZT7C1 MT DTT DMZT7C1 MA Antagonist DMZT7C1 RN CP-481,715, a potent and selective CCR1 antagonist with potential therapeutic implications for inflammatory diseases. J Biol Chem. 2003 Oct 17;278(42):40473-80. DMZT7C1 RU https://pubmed.ncbi.nlm.nih.gov/12909630 DMKWB31 DI DMKWB31 DMKWB31 DN CP55,244 DMKWB31 MI TTNET8J DMKWB31 MN G-protein coupled receptor 55 (GPR55) DMKWB31 MT DTT DMKWB31 MA Agonist DMKWB31 RN Pharmacology of GPR55 in yeast and identification of GSK494581A as a mixed-activity glycine transporter subtype 1 inhibitor and GPR55 agonist. J Pharmacol Exp Ther. 2011 Apr;337(1):236-46. DMKWB31 RU https://pubmed.ncbi.nlm.nih.gov/21233197 DMNLD6E DI DMNLD6E DMNLD6E DN CP55,667 DMNLD6E MI TTNET8J DMNLD6E MN G-protein coupled receptor 55 (GPR55) DMNLD6E MT DTT DMNLD6E MA Antagonist DMNLD6E RN Pharmacology of GPR55 in yeast and identification of GSK494581A as a mixed-activity glycine transporter subtype 1 inhibitor and GPR55 agonist. J Pharmacol Exp Ther. 2011 Apr;337(1):236-46. DMNLD6E RU https://pubmed.ncbi.nlm.nih.gov/21233197 DMTKO7P DI DMTKO7P DMTKO7P DN CP608,039 DMTKO7P MI TTK25J1 DMTKO7P MN Adenosine A1 receptor (ADORA1) DMTKO7P MT DTT DMTKO7P MA Agonist DMTKO7P RN Adenosine receptors as therapeutic targets. Nat Rev Drug Discov. 2006 Mar;5(3):247-64. DMTKO7P RU https://pubmed.ncbi.nlm.nih.gov/16518376 DMTKO7P DI DMTKO7P DMTKO7P DN CP608,039 DMTKO7P MI TTJFY5U DMTKO7P MN Adenosine A3 receptor (ADORA3) DMTKO7P MT DTT DMTKO7P MA Agonist DMTKO7P RN Novel N6-substituted adenosine 5'-N-methyluronamides with high selectivity for human adenosine A3 receptors reduce ischemic myocardial injury. Am J Physiol Heart Circ Physiol. 2003 Dec;285(6):H2780-7. DMTKO7P RU https://pubmed.ncbi.nlm.nih.gov/12919933 DMO0PS9 DI DMO0PS9 DMO0PS9 DN CP-640186 DMO0PS9 MI TTY84UG DMO0PS9 MN Acetyl-CoA carboxylase 2 (ACACB) DMO0PS9 MT DTT DMO0PS9 MA Inhibitor DMO0PS9 RN (4-Piperidinyl)-piperazine: a new platform for acetyl-CoA carboxylase inhibitors. Bioorg Med Chem Lett. 2009 Dec 1;19(23):6645-8. DMO0PS9 RU https://pubmed.ncbi.nlm.nih.gov/19853443 DMO0PS9 DI DMO0PS9 DMO0PS9 DN CP-640186 DMO0PS9 MI TTYAWV0 DMO0PS9 MN Plasmodium Acetyl-CoA carboxylase 1 (Malaria ACC1) DMO0PS9 MT DTT DMO0PS9 MA Inhibitor DMO0PS9 RN Discovery of small molecule isozyme non-specific inhibitors of mammalian acetyl-CoA carboxylase 1 and 2. Bioorg Med Chem Lett. 2010 Apr 1;20(7):2383-8. DMO0PS9 RU https://pubmed.ncbi.nlm.nih.gov/20219367 DMVBPRO DI DMVBPRO DMVBPRO DN CP-673451 DMVBPRO MI TT8FYO9 DMVBPRO MN Platelet-derived growth factor receptor alpha (PDGFRA) DMVBPRO MT DTT DMVBPRO MA Inhibitor DMVBPRO RN Antiangiogenic and antitumor activity of a selective PDGFR tyrosine kinase inhibitor, CP-673,451. Cancer Res. 2005 Feb 1;65(3):957-66. DMVBPRO RU https://pubmed.ncbi.nlm.nih.gov/15705896 DMVBPRO DI DMVBPRO DMVBPRO DN CP-673451 DMVBPRO MI TTI7421 DMVBPRO MN Platelet-derived growth factor receptor beta (PDGFRB) DMVBPRO MT DTT DMVBPRO MA Inhibitor DMVBPRO RN Antiangiogenic and antitumor activity of a selective PDGFR tyrosine kinase inhibitor, CP-673,451. Cancer Res. 2005 Feb 1;65(3):957-66. DMVBPRO RU https://pubmed.ncbi.nlm.nih.gov/15705896 DMVBPRO DI DMVBPRO DMVBPRO DN CP-673451 DMVBPRO MI TTX41N9 DMVBPRO MN Tyrosine-protein kinase Kit (KIT) DMVBPRO MT DTT DMVBPRO MA Inhibitor DMVBPRO RN Antiangiogenic and antitumor activity of a selective PDGFR tyrosine kinase inhibitor, CP-673,451. Cancer Res. 2005 Feb 1;65(3):957-66. DMVBPRO RU https://pubmed.ncbi.nlm.nih.gov/15705896 DMBQTZG DI DMBQTZG DMBQTZG DN CP-70949 DMBQTZG MI TTRSMW9 DMBQTZG MN Glycogen synthase kinase-3 beta (GSK-3B) DMBQTZG MT DTT DMBQTZG MA Inhibitor DMBQTZG RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2030). DMBQTZG RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2030 DM9LYJT DI DM9LYJT DM9LYJT DN CP734432 DM9LYJT MI TT79WV3 DM9LYJT MN Prostaglandin E2 receptor EP4 (PTGER4) DM9LYJT MT DTT DM9LYJT MA Agonist DM9LYJT RN Ocular pharmacokinetics and hypotensive activity of PF-04475270, an EP4 prostaglandin agonist in preclinical models. Exp Eye Res. 2009 Nov;89(5):608-17. DM9LYJT RU https://pubmed.ncbi.nlm.nih.gov/19445930 DMANV7R DI DMANV7R DMANV7R DN CP-775146 DMANV7R MI TTJ584C DMANV7R MN Peroxisome proliferator-activated receptor alpha (PPARA) DMANV7R MT DTT DMANV7R MA Agonist DMANV7R RN Molecular characterization of novel and selective peroxisome proliferator-activated receptor alpha agonists with robust hypolipidemic activity in vivo. Mol Pharmacol. 2009 Feb;75(2):296-306. DMANV7R RU https://pubmed.ncbi.nlm.nih.gov/18971326 DM3M1LA DI DM3M1LA DM3M1LA DN CP-809101 DM3M1LA MI TTWJBZ5 DM3M1LA MN 5-HT 2C receptor (HTR2C) DM3M1LA MT DTT DM3M1LA MA Agonist DM3M1LA RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 8). DM3M1LA RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=8 DMXDG13 DI DMXDG13 DMXDG13 DN CP-810123 DMXDG13 MI TTPC4TU DMXDG13 MN 5-HT 3A receptor (HTR3A) DMXDG13 MT DTT DMXDG13 MA Inhibitor DMXDG13 RN Discovery of 4-(5-methyloxazolo[4,5-b]pyridin-2-yl)-1,4-diazabicyclo[3.2.2]nonane (CP-810,123), a novel alpha 7 nicotinic acetylcholine receptor ag... J Med Chem. 2010 Feb 11;53(3):1222-37. DMXDG13 RU https://pubmed.ncbi.nlm.nih.gov/20043678 DMXDG13 DI DMXDG13 DMXDG13 DN CP-810123 DMXDG13 MI TTLA931 DMXDG13 MN Neuronal acetylcholine receptor alpha-7 (CHRNA7) DMXDG13 MT DTT DMXDG13 MA Inhibitor DMXDG13 RN Discovery of 4-(5-methyloxazolo[4,5-b]pyridin-2-yl)-1,4-diazabicyclo[3.2.2]nonane (CP-810,123), a novel alpha 7 nicotinic acetylcholine receptor ag... J Med Chem. 2010 Feb 11;53(3):1222-37. DMXDG13 RU https://pubmed.ncbi.nlm.nih.gov/20043678 DMHN2LT DI DMHN2LT DMHN2LT DN CP-94,253 DMHN2LT MI TTK8CXU DMHN2LT MN 5-HT 1B receptor (HTR1B) DMHN2LT MT DTT DMHN2LT MA Agonist DMHN2LT RN Anxiogenic-like effect of serotonin(1B) receptor stimulation in the rat elevated plus-maze. Pharmacol Biochem Behav. 2002 Apr;71(4):581-7. DMHN2LT RU https://pubmed.ncbi.nlm.nih.gov/11888549 DMVJX21 DI DMVJX21 DMVJX21 DN CP-99,994 DMVJX21 MI TTZPO1L DMVJX21 MN Substance-P receptor (TACR1) DMVJX21 MT DTT DMVJX21 MA Antagonist DMVJX21 RN Gabapentin and the neurokinin(1) receptor antagonist CI-1021 act synergistically in two rat models of neuropathic pain. J Pharmacol Exp Ther. 2002 Nov;303(2):730-5. DMVJX21 RU https://pubmed.ncbi.nlm.nih.gov/12388658 DMI4WVE DI DMI4WVE DMI4WVE DN CPCCOEt DMI4WVE MI TTVBPDM DMI4WVE MN Metabotropic glutamate receptor 1 (mGluR1) DMI4WVE MT DTT DMI4WVE MA Modulator (allosteric modulator) DMI4WVE RN [3H]R214127: a novel high-affinity radioligand for the mGlu1 receptor reveals a common binding site shared by multiple allosteric antagonists. Mol Pharmacol. 2003 May;63(5):1082-93. DMI4WVE RU https://pubmed.ncbi.nlm.nih.gov/12695537 DMFE5GX DI DMFE5GX DMFE5GX DN CPFPX DMFE5GX MI TTK25J1 DMFE5GX MN Adenosine A1 receptor (ADORA1) DMFE5GX MT DTT DMFE5GX MA Antagonist DMFE5GX RN Synthesis and evaluation of no-carrier-added 8-cyclopentyl-3-(3-[(18)F]fluoropropyl)-1-propylxanthine ([(18)F]CPFPX): a potent and selective A(1)-adenosine receptor antagonist for in vivo imaging. J Med Chem. 2002 Nov 7;45(23):5150-6. DMFE5GX RU https://pubmed.ncbi.nlm.nih.gov/12408725 DMFE5GX DI DMFE5GX DMFE5GX DN CPFPX DMFE5GX MI TTNE7KG DMFE5GX MN Adenosine A2b receptor (ADORA2B) DMFE5GX MT DTT DMFE5GX MA Antagonist DMFE5GX RN Synthesis and evaluation of no-carrier-added 8-cyclopentyl-3-(3-[(18)F]fluoropropyl)-1-propylxanthine ([(18)F]CPFPX): a potent and selective A(1)-adenosine receptor antagonist for in vivo imaging. J Med Chem. 2002 Nov 7;45(23):5150-6. DMFE5GX RU https://pubmed.ncbi.nlm.nih.gov/12408725 DMXSYTA DI DMXSYTA DMXSYTA DN CPI-203 DMXSYTA MI TTRA6BO DMXSYTA MN Bromodomain-containing protein 4 (BRD4) DMXSYTA MT DTT DMXSYTA MA Inhibitor DMXSYTA RN BRD4 is an atypical kinase that phosphorylates serine2 of the RNA polymerase II carboxy-terminal domain. Proc Natl Acad Sci U S A. 2012 May 1;109(18):6927-32. DMXSYTA RU https://pubmed.ncbi.nlm.nih.gov/22509028 DMVHX5T DI DMVHX5T DMVHX5T DN CPPG DMVHX5T MI TTICZ1O DMVHX5T MN Metabotropic glutamate receptor 4 (mGluR4) DMVHX5T MT DTT DMVHX5T MA Antagonist DMVHX5T RN Ligand binding to the amino-terminal domain of the mGluR4 subtype of metabotropic glutamate receptor. J Biol Chem. 1999 Apr 9;274(15):10008-13. DMVHX5T RU https://pubmed.ncbi.nlm.nih.gov/10187777 DMVHX5T DI DMVHX5T DMVHX5T DN CPPG DMVHX5T MI TT0IFKL DMVHX5T MN Metabotropic glutamate receptor 8 (mGluR8) DMVHX5T MT DTT DMVHX5T MA Antagonist DMVHX5T RN Constraints on proper folding of the amino terminal domains of group III metabotropic glutamate receptors. Brain Res Mol Brain Res. 2000 Mar 10;76(1):180-90. DMVHX5T RU https://pubmed.ncbi.nlm.nih.gov/10719229 DMDG2Y9 DI DMDG2Y9 DMDG2Y9 DN CPPHA DMDG2Y9 MI TTHS256 DMDG2Y9 MN Metabotropic glutamate receptor 5 (mGluR5) DMDG2Y9 MT DTT DMDG2Y9 MA Modulator (allosteric modulator) DMDG2Y9 RN A novel selective allosteric modulator potentiates the activity of native metabotropic glutamate receptor subtype 5 in rat forebrain. J Pharmacol Exp Ther. 2004 May;309(2):568-77. DMDG2Y9 RU https://pubmed.ncbi.nlm.nih.gov/14747613 DM9OWG5 DI DM9OWG5 DM9OWG5 DN CPPZ DM9OWG5 MI TTHS256 DM9OWG5 MN Metabotropic glutamate receptor 5 (mGluR5) DM9OWG5 MT DTT DM9OWG5 MA Modulator (allosteric modulator) DM9OWG5 RN Preclinical profile of a novel metabotropic glutamate receptor 5 positive allosteric modulator. Eur J Pharmacol. 2011 Jun 1;659(2-3):146-54. DM9OWG5 RU https://pubmed.ncbi.nlm.nih.gov/21335002 DMG2NI9 DI DMG2NI9 DMG2NI9 DN CPS125 DMG2NI9 MI TTXDKTO DMG2NI9 MN Long transient receptor potential channel 8 (TRPM8) DMG2NI9 MT DTT DMG2NI9 MA Activator DMG2NI9 RN Characterization of selective TRPM8 ligands and their structure activity response (S.A.R) relationship. J Pharm Pharm Sci. 2010;13(2):242-53. DMG2NI9 RU https://pubmed.ncbi.nlm.nih.gov/20816009 DMM8FUT DI DMM8FUT DMM8FUT DN CPU-228 DMM8FUT MI TTZIFHC DMM8FUT MN Voltage-gated calcium channel alpha Cav1.2 (CACNA1C) DMM8FUT MT DTT DMM8FUT MA Modulator DMM8FUT RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 529). DMM8FUT RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=529 DMM8FUT DI DMM8FUT DMM8FUT DN CPU-228 DMM8FUT MI TT7RGTM DMM8FUT MN Voltage-gated calcium channel alpha Cav1.3 (CACNA1D) DMM8FUT MT DTT DMM8FUT MA Modulator DMM8FUT RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 530). DMM8FUT RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=530 DMM8FUT DI DMM8FUT DMM8FUT DN CPU-228 DMM8FUT MI TTX4QDJ DMM8FUT MN Voltage-gated calcium channel alpha Cav2.1 (CACNA1A) DMM8FUT MT DTT DMM8FUT MA Modulator DMM8FUT RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 532). DMM8FUT RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=532 DMM8FUT DI DMM8FUT DMM8FUT DN CPU-228 DMM8FUT MI TT4FDG6 DMM8FUT MN Voltage-gated calcium channel alpha Cav2.2 (CACNA1B) DMM8FUT MT DTT DMM8FUT MA Modulator DMM8FUT RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 533). DMM8FUT RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=533 DMM8FUT DI DMM8FUT DMM8FUT DN CPU-228 DMM8FUT MI TTYRP0M DMM8FUT MN Voltage-gated calcium channel alpha Cav2.3 (CACNA1E) DMM8FUT MT DTT DMM8FUT MA Modulator DMM8FUT RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 534). DMM8FUT RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=534 DMFG0XS DI DMFG0XS DMFG0XS DN CR-2345 DMFG0XS MI TTCG0AL DMFG0XS MN Cholecystokinin receptor type A (CCKAR) DMFG0XS MT DTT DMFG0XS MA Inhibitor DMFG0XS RN Biological properties of (R)-4-benzamido-5-oxopentanoic basic derivatives as CCK-antagonists, Bioorg. Med. Chem. Lett. 3(5):861-866 (1993). DMFG0XS RU http://www.sciencedirect.com/science/article/pii/S0960894X00806812 DM3M5AW DI DM3M5AW DM3M5AW DN CR-4174 DM3M5AW MI TTVKILB DM3M5AW MN Prostaglandin G/H synthase 2 (COX-2) DM3M5AW MT DTT DM3M5AW MA Inhibitor DM3M5AW RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1376). DM3M5AW RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1376 DMXHIFZ DI DMXHIFZ DMXHIFZ DN CR-4892 DMXHIFZ MI TT90XZ8 DMXHIFZ MN Voltage-gated sodium channel alpha Nav1.8 (SCN10A) DMXHIFZ MT DTT DMXHIFZ MA Blocker DMXHIFZ RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 585). DMXHIFZ RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=585 DME5IJQ DI DME5IJQ DME5IJQ DN CR-5259 DME5IJQ MI TTXSU2Y DME5IJQ MN Aggrecanase (ADAMTS5) DME5IJQ MT DTT DME5IJQ MA Inhibitor DME5IJQ RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1677). DME5IJQ RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1677 DMY2P5C DI DMY2P5C DMY2P5C DN CR-5790 DMY2P5C MI TT79WV3 DMY2P5C MN Prostaglandin E2 receptor EP4 (PTGER4) DMY2P5C MT DTT DMY2P5C MA Antagonist DMY2P5C RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 343). DMY2P5C RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=343 DM70YRT DI DM70YRT DM70YRT DN CRA_10655 DM70YRT MI TTGY7WI DM70YRT MN Urokinase-type plasminogen activator (PLAU) DM70YRT MT DTT DM70YRT MA Inhibitor DM70YRT RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DM70YRT RU https://pubmed.ncbi.nlm.nih.gov/10592235 DMK54RM DI DMK54RM DMK54RM DN CRA_1144 DMK54RM MI TT25MVL DMK54RM MN Serine protease hepsin (HPN) DMK54RM MT DTT DMK54RM MA Inhibitor DMK54RM RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DMK54RM RU https://pubmed.ncbi.nlm.nih.gov/10592235 DM3IZOP DI DM3IZOP DM3IZOP DN CRA_8696 DM3IZOP MI TT6L509 DM3IZOP MN Coagulation factor IIa (F2) DM3IZOP MT DTT DM3IZOP MA Inhibitor DM3IZOP RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DM3IZOP RU https://pubmed.ncbi.nlm.nih.gov/10592235 DM3IZOP DI DM3IZOP DM3IZOP DN CRA_8696 DM3IZOP MI TTGY7WI DM3IZOP MN Urokinase-type plasminogen activator (PLAU) DM3IZOP MT DTT DM3IZOP MA Inhibitor DM3IZOP RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DM3IZOP RU https://pubmed.ncbi.nlm.nih.gov/10592235 DMPWZOK DI DMPWZOK DMPWZOK DN CRB-0022 DMPWZOK MI TTEDJN4 DMPWZOK MN Low-affinity nerve growth factor receptor (NGFR) DMPWZOK MT DTT DMPWZOK RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1888). DMPWZOK RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1888 DMLJOGK DI DMLJOGK DMLJOGK DN Cremastrine DMLJOGK MI TTZ9SOR DMLJOGK MN Muscarinic acetylcholine receptor M1 (CHRM1) DMLJOGK MT DTT DMLJOGK MA Inhibitor DMLJOGK RN Cremastrine, a pyrrolizidine alkaloid from Cremastra appendiculata. J Nat Prod. 2005 Apr;68(4):572-3. DMLJOGK RU https://pubmed.ncbi.nlm.nih.gov/15844951 DMLJOGK DI DMLJOGK DMLJOGK DN Cremastrine DMLJOGK MI TTQ13Z5 DMLJOGK MN Muscarinic acetylcholine receptor M3 (CHRM3) DMLJOGK MT DTT DMLJOGK MA Inhibitor DMLJOGK RN Cremastrine, a pyrrolizidine alkaloid from Cremastra appendiculata. J Nat Prod. 2005 Apr;68(4):572-3. DMLJOGK RU https://pubmed.ncbi.nlm.nih.gov/15844951 DMLJOGK DI DMLJOGK DMLJOGK DN Cremastrine DMLJOGK MI TTQ3JTF DMLJOGK MN Muscarinic acetylcholine receptor M4 (CHRM4) DMLJOGK MT DTT DMLJOGK MA Inhibitor DMLJOGK RN Cremastrine, a pyrrolizidine alkaloid from Cremastra appendiculata. J Nat Prod. 2005 Apr;68(4):572-3. DMLJOGK RU https://pubmed.ncbi.nlm.nih.gov/15844951 DMLJOGK DI DMLJOGK DMLJOGK DN Cremastrine DMLJOGK MI TTH18TF DMLJOGK MN Muscarinic acetylcholine receptor M5 (CHRM5) DMLJOGK MT DTT DMLJOGK MA Inhibitor DMLJOGK RN Cremastrine, a pyrrolizidine alkaloid from Cremastra appendiculata. J Nat Prod. 2005 Apr;68(4):572-3. DMLJOGK RU https://pubmed.ncbi.nlm.nih.gov/15844951 DMY0GXM DI DMY0GXM DMY0GXM DN CRISNATOL MESILATE DMY0GXM MI TTGTQHC DMY0GXM MN DNA topoisomerase I (TOP1) DMY0GXM MT DTT DMY0GXM MA Modulator DMY0GXM RN The ChEMBL database in 2017. Nucleic Acids Res. 2017 Jan 4;45(D1):D945-D954. DMY0GXM RU https://www.ncbi.nlm.nih.gov/pubmed/27899562 DMYPLZ8 DI DMYPLZ8 DMYPLZ8 DN Cristacarpin DMYPLZ8 MI TT50QJ3 DMYPLZ8 MN Influenza Neuraminidase (Influ NA) DMYPLZ8 MT DTT DMYPLZ8 MA Inhibitor DMYPLZ8 RN Prenylated pterocarpans as bacterial neuraminidase inhibitors. Bioorg Med Chem. 2010 May 1;18(9):3335-44. DMYPLZ8 RU https://pubmed.ncbi.nlm.nih.gov/20363636 DMERKU2 DI DMERKU2 DMERKU2 DN CRL-37212 DMERKU2 MI TTPMQSO DMERKU2 MN ALK tyrosine kinase receptor (ALK) DMERKU2 MT DTT DMERKU2 MA Inhibitor DMERKU2 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1839). DMERKU2 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1839 DMELUG5 DI DMELUG5 DMELUG5 DN Crocusatin-K DMELUG5 MI TTULVH8 DMELUG5 MN Tyrosinase (TYR) DMELUG5 MT DTT DMELUG5 MA Inhibitor DMELUG5 RN Antityrosinase principles and constituents of the petals of Crocus sativus. J Nat Prod. 2004 Mar;67(3):437-40. DMELUG5 RU https://pubmed.ncbi.nlm.nih.gov/15043425 DMTWRQI DI DMTWRQI DMTWRQI DN crotylaldehyde DMTWRQI MI TTFLN4T DMTWRQI MN Mitochondrial aldehyde dehydrogenase (ALDH2) DMTWRQI MT DTT DMTWRQI MA Inhibitor DMTWRQI RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMTWRQI RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMTWRQI DI DMTWRQI DMTWRQI DN crotylaldehyde DMTWRQI MI TTELV3W DMTWRQI MN Transformation-sensitive protein p120 (TRPA1) DMTWRQI MT DTT DMTWRQI MA Activator DMTWRQI RN Cigarette smoke-induced neurogenic inflammation is mediated by alpha,beta-unsaturated aldehydes and the TRPA1 receptor in rodents. J Clin Invest. 2008 Jul;118(7):2574-82. DMTWRQI RU https://pubmed.ncbi.nlm.nih.gov/18568077 DMVYSAZ DI DMVYSAZ DMVYSAZ DN CRT-0004592 DMVYSAZ MI TTWJTHX DMVYSAZ MN Protein kinase C iota (PRKCI) DMVYSAZ MT DTT DMVYSAZ MA Inhibitor DMVYSAZ RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1490). DMVYSAZ RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1490 DMX09KI DI DMX09KI DMX09KI DN CRT0066101 DMX09KI MI TTSLUMT DMX09KI MN Protein kinase D (PRKD1) DMX09KI MT DTT DMX09KI MA Inhibitor DMX09KI RN Protein kinase D as a potential new target for cancer therapy. Biochim Biophys Acta. 2010 Dec;1806(2):183-92. DMX09KI RU https://pubmed.ncbi.nlm.nih.gov/20580776 DMBV79R DI DMBV79R DMBV79R DN CRTX-070 DMBV79R MI TTH18TF DMBV79R MN Muscarinic acetylcholine receptor M5 (CHRM5) DMBV79R MT DTT DMBV79R MA Modulator DMBV79R RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 467). DMBV79R RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=467 DMW61UK DI DMW61UK DMW61UK DN CRX-526 DMW61UK MI TTISGCA DMW61UK MN Toll-like receptor 4 (TLR4) DMW61UK MT DTT DMW61UK MA Inhibitor DMW61UK RN The 'Ethereal' nature of TLR4 agonism and antagonism in the AGP class of lipid A mimetics. Bioorg Med Chem Lett. 2008 Oct 15;18(20):5350-4. DMW61UK RU https://pubmed.ncbi.nlm.nih.gov/18835160 DM92IK8 DI DM92IK8 DM92IK8 DN CRYPTADINE B DM92IK8 MI TT1RS9F DM92IK8 MN Acetylcholinesterase (AChE) DM92IK8 MT DTT DM92IK8 MA Inhibitor DM92IK8 RN Cryptadines A and B, novel C27N3-type pentacyclic alkaloids from Lycopodium cryptomerinum. Bioorg Med Chem. 2007 Dec 15;15(24):7803-8. DM92IK8 RU https://pubmed.ncbi.nlm.nih.gov/17904850 DM8W7VL DI DM8W7VL DM8W7VL DN CS-6969 DM8W7VL MI DEEG96X DM8W7VL MN Oxysterol 7-alpha-hydroxylase (CYP39A1) DM8W7VL MT DME DM8W7VL MA Metabolism DM8W7VL RN Association of CYP39A1, RUNX2 and oxidized alpha-1 antitrypsin expression in relation to cholangiocarcinoma progression. Asian Pac J Cancer Prev. 2014;15(23):10187-92. DM8W7VL RU https://pubmed.ncbi.nlm.nih.gov/25556446 DM6K123 DI DM6K123 DM6K123 DN CSC-500297 DM6K123 MI TTWJBZ5 DM6K123 MN 5-HT 2C receptor (HTR2C) DM6K123 MT DTT DM6K123 MA Agonist DM6K123 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 8). DM6K123 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=8 DMTN1P2 DI DMTN1P2 DMTN1P2 DN CSL-324 DMTN1P2 MI TTC70AJ DMTN1P2 MN Granulocyte colony-stimulating factor receptor (G-CSF-R) DMTN1P2 MT DTT DMTN1P2 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1719). DMTN1P2 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1719 DMYDTO8 DI DMYDTO8 DMYDTO8 DN CSNLSTCVLGKLSQELc[DKLHK]YPRTNTGSGTP-amide DMYDTO8 MI TTLWS2O DMYDTO8 MN Calcitonin receptor (CALCR) DMYDTO8 MT DTT DMYDTO8 MA Inhibitor DMYDTO8 RN Side-chain lactam-bridge conformational constraints differentiate the activities of salmon and human calcitonins and reveal a new design concept fo... J Med Chem. 2002 Feb 28;45(5):1108-21. DMYDTO8 RU https://pubmed.ncbi.nlm.nih.gov/11855991 DMQXEHJ DI DMQXEHJ DMQXEHJ DN CSNLSTCVLGKLSQELc[DKLHO]YPRTNTGSGTP-amide DMQXEHJ MI TTLWS2O DMQXEHJ MN Calcitonin receptor (CALCR) DMQXEHJ MT DTT DMQXEHJ MA Inhibitor DMQXEHJ RN Side-chain lactam-bridge conformational constraints differentiate the activities of salmon and human calcitonins and reveal a new design concept fo... J Med Chem. 2002 Feb 28;45(5):1108-21. DMQXEHJ RU https://pubmed.ncbi.nlm.nih.gov/11855991 DMMZK89 DI DMMZK89 DMMZK89 DN CSNLSTCVLGKLSQELc[DKLQK]YPRTNTGSGTP-amide DMMZK89 MI TTLWS2O DMMZK89 MN Calcitonin receptor (CALCR) DMMZK89 MT DTT DMMZK89 MA Inhibitor DMMZK89 RN Side-chain lactam-bridge conformational constraints differentiate the activities of salmon and human calcitonins and reveal a new design concept fo... J Med Chem. 2002 Feb 28;45(5):1108-21. DMMZK89 RU https://pubmed.ncbi.nlm.nih.gov/11855991 DMTL2BA DI DMTL2BA DMTL2BA DN CSNLSTCVLGKLSQELHKLQTYPRTNTGSGTP-amide DMTL2BA MI TTLWS2O DMTL2BA MN Calcitonin receptor (CALCR) DMTL2BA MT DTT DMTL2BA MA Inhibitor DMTL2BA RN Side-chain lactam-bridge conformational constraints differentiate the activities of salmon and human calcitonins and reveal a new design concept fo... J Med Chem. 2002 Feb 28;45(5):1108-21. DMTL2BA RU https://pubmed.ncbi.nlm.nih.gov/11855991 DM61V5W DI DM61V5W DM61V5W DN CSNLSTCVLGKLSQELNKLHBYPRTNTGSGTP-amide DM61V5W MI TTLWS2O DM61V5W MN Calcitonin receptor (CALCR) DM61V5W MT DTT DM61V5W MA Inhibitor DM61V5W RN Side-chain lactam-bridge conformational constraints differentiate the activities of salmon and human calcitonins and reveal a new design concept fo... J Med Chem. 2002 Feb 28;45(5):1108-21. DM61V5W RU https://pubmed.ncbi.nlm.nih.gov/11855991 DM3W6PQ DI DM3W6PQ DM3W6PQ DN CT-003230 DM3W6PQ MI TTE4KHA DM3W6PQ MN Amyloid beta A4 protein (APP) DM3W6PQ MT DTT DM3W6PQ MA Inhibitor DM3W6PQ RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2402). DM3W6PQ RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2402 DMIVNMJ DI DMIVNMJ DMIVNMJ DN CT-10 DMIVNMJ MI TTIKWV4 DMIVNMJ MN Geranyltranstransferase (FDPS) DMIVNMJ MT DTT DMIVNMJ MA Inhibitor DMIVNMJ RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 643). DMIVNMJ RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=643 DMUVQFW DI DMUVQFW DMUVQFW DN CT301 DMUVQFW MI TT4BT06 DMUVQFW MN Integrin alpha-4 (ITGA4) DMUVQFW MT DTT DMUVQFW MA Antagonist DMUVQFW RN Prolonged reversal of chronic experimental allergic encephalomyelitis using a small molecule inhibitor of alpha4 integrin. J Neuroimmunol. 2002 Oct;131(1-2):147-59. DMUVQFW RU https://pubmed.ncbi.nlm.nih.gov/12458046 DM6W9LA DI DM6W9LA DM6W9LA DN CT-5357 DM6W9LA MI TTV5CGO DM6W9LA MN Phosphodiesterase 4 (PDE4) DM6W9LA MT DTT DM6W9LA MA Modulator DM6W9LA RN The ChEMBL database in 2017. Nucleic Acids Res. 2017 Jan 4;45(D1):D945-D954. DM6W9LA RU https://www.ncbi.nlm.nih.gov/pubmed/27899562 DM6F8DM DI DM6F8DM DM6F8DM DN CT-98024 DM6F8DM MI TTRSMW9 DM6F8DM MN Glycogen synthase kinase-3 beta (GSK-3B) DM6F8DM MT DTT DM6F8DM MA Inhibitor DM6F8DM RN Discovery of potent and bioavailable GSK-3beta inhibitors. Bioorg Med Chem Lett. 2010 Mar 1;20(5):1693-6. DM6F8DM RU https://pubmed.ncbi.nlm.nih.gov/20138512 DMLON9K DI DMLON9K DMLON9K DN CTAP DMLON9K MI TT27RFC DMLON9K MN Opioid receptor delta (OPRD1) DMLON9K MT DTT DMLON9K MA Antagonist DMLON9K RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 317). DMLON9K RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=317 DMLON9K DI DMLON9K DMLON9K DN CTAP DMLON9K MI TTKWM86 DMLON9K MN Opioid receptor mu (MOP) DMLON9K MT DTT DMLON9K MA Antagonist DMLON9K RN Potent morphiceptin analogs: structure activity relationships and morphine-like activities. J Pharmacol Exp Ther. 1983 Nov;227(2):403-8. DMLON9K RU https://pubmed.ncbi.nlm.nih.gov/6313901 DMEGZHF DI DMEGZHF DMEGZHF DN CTCE-0324 DMEGZHF MI TTBID49 DMEGZHF MN C-X-C chemokine receptor type 4 (CXCR4) DMEGZHF MT DTT DMEGZHF MA Modulator DMEGZHF RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 71). DMEGZHF RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=71 DMYRVZ8 DI DMYRVZ8 DMYRVZ8 DN CTEP DMYRVZ8 MI TTHS256 DMYRVZ8 MN Metabotropic glutamate receptor 5 (mGluR5) DMYRVZ8 MT DTT DMYRVZ8 MA Antagonist DMYRVZ8 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 293). DMYRVZ8 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=293 DMI3J0F DI DMI3J0F DMI3J0F DN CTK1G9578 DMI3J0F MI DE4LYSA DMI3J0F MN Cytochrome P450 3A4 (CYP3A4) DMI3J0F MT DME DMI3J0F MA Metabolism DMI3J0F RN Structure and mechanism of the complex between cytochrome P4503A4 and ritonavir. Proc Natl Acad Sci U S A. 2010 Oct 26;107(43):18422-7. DMI3J0F RU https://www.ncbi.nlm.nih.gov/pubmed/?term=20937904 DMKEIAS DI DMKEIAS DMKEIAS DN CTLA-4-XTEN DMKEIAS MI TTI2S1D DMKEIAS MN Cytotoxic T-lymphocyte protein 4 (CTLA-4) DMKEIAS MT DTT DMKEIAS MA Modulator DMKEIAS RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2743). DMKEIAS RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2743 DM7VAJX DI DM7VAJX DM7VAJX DN CTOP DM7VAJX MI TT27RFC DM7VAJX MN Opioid receptor delta (OPRD1) DM7VAJX MT DTT DM7VAJX MA Inhibitor DM7VAJX RN Novel opioid peptide derived antagonists containing (2S)-2-methyl-3-(2,6-dimethyl-4-carbamoylphenyl)propanoic acid [(2S)-Mdcp]. J Med Chem. 2008 Sep 25;51(18):5866-70. DM7VAJX RU https://pubmed.ncbi.nlm.nih.gov/18800771 DM7VAJX DI DM7VAJX DM7VAJX DN CTOP DM7VAJX MI TTKWM86 DM7VAJX MN Opioid receptor mu (MOP) DM7VAJX MT DTT DM7VAJX MA Antagonist DM7VAJX RN Pharmacological characterization of the cloned kappa-, delta-, and mu-opioid receptors. Mol Pharmacol. 1994 Feb;45(2):330-4. DM7VAJX RU https://pubmed.ncbi.nlm.nih.gov/8114680 DM4T62U DI DM4T62U DM4T62U DN CTP DM4T62U MI TT24DGP DM4T62U MN P2Y purinoceptor 4 (P2RY4) DM4T62U MT DTT DM4T62U MA Agonist DM4T62U RN ATP, an agonist at the rat P2Y(4) receptor, is an antagonist at the human P2Y(4) receptor. Mol Pharmacol. 2000 May;57(5):926-31. DM4T62U RU https://pubmed.ncbi.nlm.nih.gov/10779375 DMQ5JX8 DI DMQ5JX8 DMQ5JX8 DN CTT-54 DMQ5JX8 MI TT9G4N0 DMQ5JX8 MN Glutamate carboxypeptidase II (GCPII) DMQ5JX8 MT DTT DMQ5JX8 MA Modulator DMQ5JX8 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1606). DMQ5JX8 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1606 DMDPJWF DI DMDPJWF DMDPJWF DN CU201 (B9870) DMDPJWF MI TTDJ4MY DMDPJWF MN Kininogen (KNG1) DMDPJWF MT DTT DMDPJWF MA Inhibitor DMDPJWF RN Bradykinin antagonist dimer, CU201, inhibits the growth of human lung cancer cell lines in vitro and in vivo and produces synergistic growth inhibition in combination with other antitumor agents. Clin Cancer Res. 2002 May;8(5):1280-7. DMDPJWF RU https://pubmed.ncbi.nlm.nih.gov/12006549 DMY1WEM DI DMY1WEM DMY1WEM DN CU-906 DMY1WEM MI TTHBTOP DMY1WEM MN PI3-kinase gamma (PIK3CG) DMY1WEM MT DTT DMY1WEM MA Inhibitor DMY1WEM RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2155). DMY1WEM RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2155 DMY1WEM DI DMY1WEM DMY1WEM DN CU-906 DMY1WEM MI TTCJG29 DMY1WEM MN Serine/threonine-protein kinase mTOR (mTOR) DMY1WEM MT DTT DMY1WEM MA Inhibitor DMY1WEM RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2109). DMY1WEM RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2109 DMBL46A DI DMBL46A DMBL46A DN CUDRATRICUSXANTHONE DMBL46A MI TT50QJ3 DMBL46A MN Influenza Neuraminidase (Influ NA) DMBL46A MT DTT DMBL46A MA Inhibitor DMBL46A RN Characteristic of neuraminidase inhibitory xanthones from Cudrania tricuspidata. Bioorg Med Chem. 2009 Apr 1;17(7):2744-50. DMBL46A RU https://pubmed.ncbi.nlm.nih.gov/19285413 DM10BOC DI DM10BOC DM10BOC DN Cudratricusxanthone F DM10BOC MI TT50QJ3 DM10BOC MN Influenza Neuraminidase (Influ NA) DM10BOC MT DTT DM10BOC MA Inhibitor DM10BOC RN Characteristic of neuraminidase inhibitory xanthones from Cudrania tricuspidata. Bioorg Med Chem. 2009 Apr 1;17(7):2744-50. DM10BOC RU https://pubmed.ncbi.nlm.nih.gov/19285413 DMBQ1VO DI DMBQ1VO DMBQ1VO DN Cudraxanthone D DMBQ1VO MI TT50QJ3 DMBQ1VO MN Influenza Neuraminidase (Influ NA) DMBQ1VO MT DTT DMBQ1VO MA Inhibitor DMBQ1VO RN Characteristic of neuraminidase inhibitory xanthones from Cudrania tricuspidata. Bioorg Med Chem. 2009 Apr 1;17(7):2744-50. DMBQ1VO RU https://pubmed.ncbi.nlm.nih.gov/19285413 DMP1D5Q DI DMP1D5Q DMP1D5Q DN Cudraxanthone L DMP1D5Q MI TT50QJ3 DMP1D5Q MN Influenza Neuraminidase (Influ NA) DMP1D5Q MT DTT DMP1D5Q MA Inhibitor DMP1D5Q RN Characteristic of neuraminidase inhibitory xanthones from Cudrania tricuspidata. Bioorg Med Chem. 2009 Apr 1;17(7):2744-50. DMP1D5Q RU https://pubmed.ncbi.nlm.nih.gov/19285413 DMIQFAU DI DMIQFAU DMIQFAU DN Cudraxanthone M DMIQFAU MI TT50QJ3 DMIQFAU MN Influenza Neuraminidase (Influ NA) DMIQFAU MT DTT DMIQFAU MA Inhibitor DMIQFAU RN Characteristic of neuraminidase inhibitory xanthones from Cudrania tricuspidata. Bioorg Med Chem. 2009 Apr 1;17(7):2744-50. DMIQFAU RU https://pubmed.ncbi.nlm.nih.gov/19285413 DMEB0FX DI DMEB0FX DMEB0FX DN CV-11194 DMEB0FX MI TT8DBY3 DMEB0FX MN Angiotensin II receptor type-1 (AGTR1) DMEB0FX MT DTT DMEB0FX MA Inhibitor DMEB0FX RN Synthesis and angiotensin II receptor antagonistic activities of benzimidazole derivatives bearing acidic heterocycles as novel tetrazole bioisoste... J Med Chem. 1996 Dec 20;39(26):5228-35. DMEB0FX RU https://pubmed.ncbi.nlm.nih.gov/8978851 DM9AL7W DI DM9AL7W DM9AL7W DN CV-1674 DM9AL7W MI TTNE7KG DM9AL7W MN Adenosine A2b receptor (ADORA2B) DM9AL7W MT DTT DM9AL7W MA Agonist DM9AL7W RN Differences in the order of potency for agonists but not antagonists at human and rat adenosine A2A receptors. Biochem Pharmacol. 1999 Jan 1;57(1):65-75. DM9AL7W RU https://pubmed.ncbi.nlm.nih.gov/9920286 DM07VRS DI DM07VRS DM07VRS DN CV-1808 DM07VRS MI TTNE7KG DM07VRS MN Adenosine A2b receptor (ADORA2B) DM07VRS MT DTT DM07VRS MA Agonist DM07VRS RN Characterization of human A2A adenosine receptors with the antagonist radioligand [3H]-SCH 58261. Br J Pharmacol. 1997 Jun;121(3):353-60. DM07VRS RU https://pubmed.ncbi.nlm.nih.gov/9179373 DMM7RAD DI DMM7RAD DMM7RAD DN CV-3988 DMM7RAD MI TTQL5VC DMM7RAD MN Platelet-activating factor receptor (PTAFR) DMM7RAD MT DTT DMM7RAD MA Antagonist DMM7RAD RN Inhibition by CV-3988 of the binding of [3H]-platelet activating factor (PAF) to the platelet. Biochem Pharmacol. 1985 May 1;34(9):1491-5. DMM7RAD RU https://pubmed.ncbi.nlm.nih.gov/2986648 DM983QP DI DM983QP DM983QP DN CV-4093 DM983QP MI DE4LYSA DM983QP MN Cytochrome P450 3A4 (CYP3A4) DM983QP MT DME DM983QP MA Metabolism DM983QP RN Effect of grapefruit juice on the disposition of manidipine enantiomers in healthy subjects. Br J Clin Pharmacol. 2006 May;61(5):533-7. DM983QP RU https://www.ncbi.nlm.nih.gov/pubmed/?term=16669846 DM983QP DI DM983QP DM983QP DN CV-4093 DM983QP MI TTZIFHC DM983QP MN Voltage-gated calcium channel alpha Cav1.2 (CACNA1C) DM983QP MT DTT DM983QP MA Inhibitor DM983QP RN Dihydropyrimidines: novel calcium antagonists with potent and long-lasting vasodilative and antihypertensive activity. J Med Chem. 1989 Oct;32(10):2399-406. DM983QP RU https://pubmed.ncbi.nlm.nih.gov/2552119 DM983QP DI DM983QP DM983QP DN CV-4093 DM983QP MI TT7RGTM DM983QP MN Voltage-gated calcium channel alpha Cav1.3 (CACNA1D) DM983QP MT DTT DM983QP MA Inhibitor DM983QP RN Dihydropyrimidines: novel calcium antagonists with potent and long-lasting vasodilative and antihypertensive activity. J Med Chem. 1989 Oct;32(10):2399-406. DM983QP RU https://pubmed.ncbi.nlm.nih.gov/2552119 DMO9WZN DI DMO9WZN DMO9WZN DN CV-6504.HCL DMO9WZN MI TTKNWZ4 DMO9WZN MN Thromboxane-A synthase (TBXAS1) DMO9WZN MT DTT DMO9WZN MA Modulator DMO9WZN RN Involvement of thromboxane A2, leukotrienes and free radicals in puromycin nephrosis in rats. Kidney Int. 1991 May;39(5):920-9. DMO9WZN RU https://pubmed.ncbi.nlm.nih.gov/2067208 DMO9UMK DI DMO9UMK DMO9UMK DN CVS-1578 DMO9UMK MI TT6L509 DMO9UMK MN Coagulation factor IIa (F2) DMO9UMK MT DTT DMO9UMK MA Modulator DMO9UMK RN Design and construction of novel thrombin inhibitors featuring P3-P4 quaternary lactam dipeptide surrogates. Bioorg Med Chem Lett. 1998 Sep 22;8(18):2501-6. DMO9UMK RU https://www.ncbi.nlm.nih.gov/pubmed/9873569 DMT5R1Q DI DMT5R1Q DMT5R1Q DN CVS-2139 DMT5R1Q MI TT2WR1T DMT5R1Q MN Cationic trypsinogen (PRSS1) DMT5R1Q MT DTT DMT5R1Q MA Inhibitor DMT5R1Q RN Non-covalent thrombin inhibitors featuring P(3)-heterocycles with P(1)-monocyclic arginine surrogates. Bioorg Med Chem Lett. 2002 Apr 22;12(8):1203-8. DMT5R1Q RU https://pubmed.ncbi.nlm.nih.gov/11934589 DM3KB4H DI DM3KB4H DM3KB4H DN CVS-2359 DM3KB4H MI TT2WR1T DM3KB4H MN Cationic trypsinogen (PRSS1) DM3KB4H MT DTT DM3KB4H MA Inhibitor DM3KB4H RN Non-covalent thrombin inhibitors featuring P(3)-heterocycles with P(1)-monocyclic arginine surrogates. Bioorg Med Chem Lett. 2002 Apr 22;12(8):1203-8. DM3KB4H RU https://pubmed.ncbi.nlm.nih.gov/11934589 DMDH6PJ DI DMDH6PJ DMDH6PJ DN CVT-10216 DMDH6PJ MI TTFLN4T DMDH6PJ MN Mitochondrial aldehyde dehydrogenase (ALDH2) DMDH6PJ MT DTT DMDH6PJ MA Antagonist DMDH6PJ RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2595). DMDH6PJ RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2595 DMOCKMZ DI DMOCKMZ DMOCKMZ DN CVT-12012 DMOCKMZ MI TT6RIOV DMOCKMZ MN Acyl-CoA desaturase (SCD) DMOCKMZ MT DTT DMOCKMZ MA Inhibitor DMOCKMZ RN Potent, orally bioavailable, liver-selective stearoyl-CoA desaturase (SCD) inhibitors. Bioorg Med Chem Lett. 2009 Aug 1;19(15):4070-4. DMOCKMZ RU https://pubmed.ncbi.nlm.nih.gov/19577469 DMSEK5W DI DMSEK5W DMSEK5W DN CVT-313 DMSEK5W MI TTH6V3D DMSEK5W MN Cyclin-dependent kinase 1 (CDK1) DMSEK5W MT DTT DMSEK5W MA Inhibitor DMSEK5W RN A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases. Proc Natl Acad Sci U S A. 2007 Dec 18;104(51):20523-8. DMSEK5W RU https://pubmed.ncbi.nlm.nih.gov/18077363 DMSEK5W DI DMSEK5W DMSEK5W DN CVT-313 DMSEK5W MI TT7HF4W DMSEK5W MN Cyclin-dependent kinase 2 (CDK2) DMSEK5W MT DTT DMSEK5W MA Inhibitor DMSEK5W RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1973). DMSEK5W RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1973 DMYC1DW DI DMYC1DW DMYC1DW DN CVT-6694 DMYC1DW MI TTNE7KG DMYC1DW MN Adenosine A2b receptor (ADORA2B) DMYC1DW MT DTT DMYC1DW MA Inhibitor DMYC1DW RN Insights into binding modes of adenosine A(2B) antagonists with ligand-based and receptor-based methods. Eur J Med Chem. 2010 Aug;45(8):3459-71. DMYC1DW RU https://pubmed.ncbi.nlm.nih.gov/20537438 DM53VA8 DI DM53VA8 DM53VA8 DN CVT-7124 DM53VA8 MI TTNE7KG DM53VA8 MN Adenosine A2b receptor (ADORA2B) DM53VA8 MT DTT DM53VA8 MA Inhibitor DM53VA8 RN Insights into binding modes of adenosine A(2B) antagonists with ligand-based and receptor-based methods. Eur J Med Chem. 2010 Aug;45(8):3459-71. DM53VA8 RU https://pubmed.ncbi.nlm.nih.gov/20537438 DMXMIT4 DI DMXMIT4 DMXMIT4 DN CX-02 DMXMIT4 MI TTBID49 DMXMIT4 MN C-X-C chemokine receptor type 4 (CXCR4) DMXMIT4 MT DTT DMXMIT4 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 71). DMXMIT4 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=71 DM7293Q DI DM7293Q DM7293Q DN CX-1001 DM7293Q MI TT3ROYC DM7293Q MN Serotonin transporter (SERT) DM7293Q MT DTT DM7293Q MA Binder DM7293Q RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 928). DM7293Q RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=928 DMCNEXF DI DMCNEXF DMCNEXF DN CX4 DMCNEXF MI TTZ4MTQ DMCNEXF MN Voltage-gated potassium channel Kv12.2 (KCNH3) DMCNEXF MT DTT DMCNEXF MA Inhibitor (gating inhibitor) DMCNEXF RN Deletion of the potassium channel Kv12.2 causes hippocampal hyperexcitability and epilepsy. Nat Neurosci. 2010 Sep;13(9):1056-8. DMCNEXF RU https://pubmed.ncbi.nlm.nih.gov/20676103 DMXD1IN DI DMXD1IN DMXD1IN DN CX-5011 DMXD1IN MI TTER6YH DMXD1IN MN Casein kinase II alpha (CSNK2A1) DMXD1IN MT DTT DMXD1IN MA Inhibitor DMXD1IN RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1549). DMXD1IN RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1549 DMNTAV8 DI DMNTAV8 DMNTAV8 DN CX-7000 DMNTAV8 MI TTER6YH DMNTAV8 MN Casein kinase II alpha (CSNK2A1) DMNTAV8 MT DTT DMNTAV8 MA Inhibitor DMNTAV8 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1549). DMNTAV8 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1549 DM526C9 DI DM526C9 DM526C9 DN CX-9051 DM526C9 MI TTVKILB DM526C9 MN Prostaglandin G/H synthase 2 (COX-2) DM526C9 MT DTT DM526C9 MA Inhibitor DM526C9 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1376). DM526C9 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1376 DMAPRDE DI DMAPRDE DMAPRDE DN CXB-029 DMAPRDE MI TT6OEDT DMAPRDE MN Cannabinoid receptor 1 (CB1) DMAPRDE MT DTT DMAPRDE MA Antagonist DMAPRDE RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 56). DMAPRDE RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=56 DMG1SXD DI DMG1SXD DMG1SXD DN CXCL8 DMG1SXD MI TT30C9G DMG1SXD MN C-X-C chemokine receptor type 2 (CXCR2) DMG1SXD MT DTT DMG1SXD MA Agonist DMG1SXD RN Noncompetitive allosteric inhibitors of the inflammatory chemokine receptors CXCR1 and CXCR2: prevention of reperfusion injury. Proc Natl Acad Sci U S A. 2004 Aug 10;101(32):11791-6. DMG1SXD RU https://pubmed.ncbi.nlm.nih.gov/15282370 DMG1SXD DI DMG1SXD DMG1SXD DN CXCL8 DMG1SXD MI TTBID49 DMG1SXD MN C-X-C chemokine receptor type 4 (CXCR4) DMG1SXD MT DTT DMG1SXD MA Agonist DMG1SXD RN Noncompetitive allosteric inhibitors of the inflammatory chemokine receptors CXCR1 and CXCR2: prevention of reperfusion injury. Proc Natl Acad Sci U S A. 2004 Aug 10;101(32):11791-6. DMG1SXD RU https://pubmed.ncbi.nlm.nih.gov/15282370 DMNSUD9 DI DMNSUD9 DMNSUD9 DN CXCR4 gene disrupted T cells DMNSUD9 MI TTBID49 DMNSUD9 MN C-X-C chemokine receptor type 4 (CXCR4) DMNSUD9 MT DTT DMNSUD9 MA Modulator DMNSUD9 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 71). DMNSUD9 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=71 DMBKTHI DI DMBKTHI DMBKTHI DN Cy3B-telenzepine DMBKTHI MI TTOXS3C DMBKTHI MN Muscarinic acetylcholine receptor (CHRM) DMBKTHI MT DTT DMBKTHI MA Antagonist DMBKTHI RN Formation and dissociation of M1 muscarinic receptor dimers seen by total internal reflection fluorescence imaging of single molecules. Proc Natl Acad Sci U S A. 2010 Feb 9;107(6):2693-8. DMBKTHI RU https://pubmed.ncbi.nlm.nih.gov/20133736 DMZ6YPV DI DMZ6YPV DMZ6YPV DN Cyamemazine DMZ6YPV MI TTSQIFT DMZ6YPV MN 5-HT 1A receptor (HTR1A) DMZ6YPV MT DTT DMZ6YPV MA Antagonist DMZ6YPV RN Affinity of cyamemazine, an anxiolytic antipsychotic drug, for human recombinant dopamine vs. serotonin receptor subtypes. Biochem Pharmacol. 2003 Feb 1;65(3):435-40. DMZ6YPV RU https://pubmed.ncbi.nlm.nih.gov/12527336 DMZ6YPV DI DMZ6YPV DMZ6YPV DN Cyamemazine DMZ6YPV MI TTJQOD7 DMZ6YPV MN 5-HT 2A receptor (HTR2A) DMZ6YPV MT DTT DMZ6YPV MA Antagonist DMZ6YPV RN Affinity of cyamemazine, an anxiolytic antipsychotic drug, for human recombinant dopamine vs. serotonin receptor subtypes. Biochem Pharmacol. 2003 Feb 1;65(3):435-40. DMZ6YPV RU https://pubmed.ncbi.nlm.nih.gov/12527336 DMZ6YPV DI DMZ6YPV DMZ6YPV DN Cyamemazine DMZ6YPV MI TTWJBZ5 DMZ6YPV MN 5-HT 2C receptor (HTR2C) DMZ6YPV MT DTT DMZ6YPV MA Antagonist DMZ6YPV RN Affinity of cyamemazine, an anxiolytic antipsychotic drug, for human recombinant dopamine vs. serotonin receptor subtypes. Biochem Pharmacol. 2003 Feb 1;65(3):435-40. DMZ6YPV RU https://pubmed.ncbi.nlm.nih.gov/12527336 DMZ6YPV DI DMZ6YPV DMZ6YPV DN Cyamemazine DMZ6YPV MI TTO9X1H DMZ6YPV MN 5-HT 7 receptor (HTR7) DMZ6YPV MT DTT DMZ6YPV MA Antagonist DMZ6YPV RN Affinity of cyamemazine, an anxiolytic antipsychotic drug, for human recombinant dopamine vs. serotonin receptor subtypes. Biochem Pharmacol. 2003 Feb 1;65(3):435-40. DMZ6YPV RU https://pubmed.ncbi.nlm.nih.gov/12527336 DMZ6YPV DI DMZ6YPV DMZ6YPV DN Cyamemazine DMZ6YPV MI DEJGDUW DMZ6YPV MN Cytochrome P450 1A2 (CYP1A2) DMZ6YPV MT DME DMZ6YPV MA Metabolism DMZ6YPV RN Characterization of human cytochrome P450 enzymes involved in the metabolism of cyamemazine. Eur J Pharm Sci. 2007 Dec;32(4-5):357-66. DMZ6YPV RU https://www.ncbi.nlm.nih.gov/pubmed/?term=17951033 DMZ6YPV DI DMZ6YPV DMZ6YPV DN Cyamemazine DMZ6YPV MI DES5XRU DMZ6YPV MN Cytochrome P450 2C8 (CYP2C8) DMZ6YPV MT DME DMZ6YPV MA Metabolism DMZ6YPV RN Characterization of human cytochrome P450 enzymes involved in the metabolism of cyamemazine. Eur J Pharm Sci. 2007 Dec;32(4-5):357-66. DMZ6YPV RU https://www.ncbi.nlm.nih.gov/pubmed/?term=17951033 DMZ6YPV DI DMZ6YPV DMZ6YPV DN Cyamemazine DMZ6YPV MI DE5IED8 DMZ6YPV MN Cytochrome P450 2C9 (CYP2C9) DMZ6YPV MT DME DMZ6YPV MA Metabolism DMZ6YPV RN Characterization of human cytochrome P450 enzymes involved in the metabolism of cyamemazine. Eur J Pharm Sci. 2007 Dec;32(4-5):357-66. DMZ6YPV RU https://www.ncbi.nlm.nih.gov/pubmed/?term=17951033 DMZ6YPV DI DMZ6YPV DMZ6YPV DN Cyamemazine DMZ6YPV MI DE4LYSA DMZ6YPV MN Cytochrome P450 3A4 (CYP3A4) DMZ6YPV MT DME DMZ6YPV MA Metabolism DMZ6YPV RN Characterization of human cytochrome P450 enzymes involved in the metabolism of cyamemazine. Eur J Pharm Sci. 2007 Dec;32(4-5):357-66. DMZ6YPV RU https://www.ncbi.nlm.nih.gov/pubmed/?term=17951033 DM6HQDL DI DM6HQDL DM6HQDL DN CYANATE DM6HQDL MI TTHQPL7 DM6HQDL MN Carbonic anhydrase I (CA-I) DM6HQDL MT DTT DM6HQDL MA Inhibitor DM6HQDL RN Carbonic anhydrase inhibitors: inhibition of the membrane-bound human isozyme IV with anions. Bioorg Med Chem Lett. 2004 Dec 6;14(23):5769-73. DM6HQDL RU https://pubmed.ncbi.nlm.nih.gov/15501038 DMJE4HK DI DMJE4HK DMJE4HK DN Cyanide DMJE4HK MI TT3PQ2Y DMJE4HK MN Plasmodium Dihydroorotate dehydrogenase (Malaria DHOdehase) DMJE4HK MT DTT DMJE4HK MA Inhibitor DMJE4HK RN Effects of atovaquone and other inhibitors on Pneumocystis carinii dihydroorotate dehydrogenase. Antimicrob Agents Chemother. 1995 Feb;39(2):325-8. DMJE4HK RU https://pubmed.ncbi.nlm.nih.gov/7726490 DMZBDO1 DI DMZBDO1 DMZBDO1 DN CYANIDIN DMZBDO1 MI TTV9A7R DMZBDO1 MN Lactoylglutathione lyase (GLO1) DMZBDO1 MT DTT DMZBDO1 MA Inhibitor DMZBDO1 RN Delphinidin, a dietary anthocyanidin in berry fruits, inhibits human glyoxalase I. Bioorg Med Chem. 2010 Oct 1;18(19):7029-33. DMZBDO1 RU https://pubmed.ncbi.nlm.nih.gov/20801663 DMIBLGH DI DMIBLGH DMIBLGH DN Cyanopindolol DMIBLGH MI TTWT5K7 DMIBLGH MN 5-HT 1 receptor (5HT1R) DMIBLGH MT DTT DMIBLGH MA Antagonist DMIBLGH RN The inhibitory effect of serotonin on the spontaneous discharge of suprachiasmatic neurons in hypothalamic slice is mediated by 5-HT(7) receptor. Brain Res Bull. 2001 Mar 1;54(4):395-8. DMIBLGH RU https://pubmed.ncbi.nlm.nih.gov/11306191 DMC6DAZ DI DMC6DAZ DMC6DAZ DN CYCLAZOCINE DMC6DAZ MI TT27RFC DMC6DAZ MN Opioid receptor delta (OPRD1) DMC6DAZ MT DTT DMC6DAZ MA Inhibitor DMC6DAZ RN Redefining the structure-activity relationships of 2,6-methano-3-benzazocines. Part 7: syntheses and opioid receptor properties of cyclic variants ... Bioorg Med Chem Lett. 2009 Jan 15;19(2):365-8. DMC6DAZ RU https://pubmed.ncbi.nlm.nih.gov/19091564 DMC6DAZ DI DMC6DAZ DMC6DAZ DN CYCLAZOCINE DMC6DAZ MI TTQW87Y DMC6DAZ MN Opioid receptor kappa (OPRK1) DMC6DAZ MT DTT DMC6DAZ MA Inhibitor DMC6DAZ RN Synthesis and opioid receptor affinity of morphinan and benzomorphan derivatives: mixed kappa agonists and mu agonists/antagonists as potential pha... J Med Chem. 2000 Jan 13;43(1):114-22. DMC6DAZ RU https://pubmed.ncbi.nlm.nih.gov/10633042 DMC6DAZ DI DMC6DAZ DMC6DAZ DN CYCLAZOCINE DMC6DAZ MI TTKWM86 DMC6DAZ MN Opioid receptor mu (MOP) DMC6DAZ MT DTT DMC6DAZ MA Inhibitor DMC6DAZ RN Synthesis and opioid receptor affinity of morphinan and benzomorphan derivatives: mixed kappa agonists and mu agonists/antagonists as potential pha... J Med Chem. 2000 Jan 13;43(1):114-22. DMC6DAZ RU https://pubmed.ncbi.nlm.nih.gov/10633042 DMPXHO8 DI DMPXHO8 DMPXHO8 DN Cyclazosin DMPXHO8 MI TTBRKXS DMPXHO8 MN Adrenergic receptor alpha-1B (ADRA1B) DMPXHO8 MT DTT DMPXHO8 MA Antagonist DMPXHO8 RN Identification of alpha1-adrenoceptor subtypes involved in contraction of young CD rat epididymal vas deferens. Eur J Pharmacol. 2009 Jan 14;602(2-3):388-94. DMPXHO8 RU https://pubmed.ncbi.nlm.nih.gov/19041301 DMVJL8H DI DMVJL8H DMVJL8H DN cyclic CMP DMVJL8H MI TT9EUT4 DMVJL8H MN Hyperpolarization cyclic nucleotide-gated channel 2 (HCN2) DMVJL8H MT DTT DMVJL8H MA Activator DMVJL8H RN Regulation of hyperpolarization-activated cyclic nucleotide-gated (HCN) channel activity by cCMP. J Biol Chem. 2012 Aug 3;287(32):26506-12. DMVJL8H RU https://pubmed.ncbi.nlm.nih.gov/22715094 DMOU93V DI DMOU93V DMOU93V DN Cyclic guanosine monophosphate DMOU93V MI TTNAHEX DMOU93V MN cAMP-dependent protein kinase A type I (PRKAR1A) DMOU93V MT DTT DMOU93V MA Inhibitor DMOU93V RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMOU93V RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMOU93V DI DMOU93V DMOU93V DN Cyclic guanosine monophosphate DMOU93V MI TTJGW1Z DMOU93V MN Phosphodiesterase 2A (PDE2A) DMOU93V MT DTT DMOU93V MA Inhibitor DMOU93V RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMOU93V RU https://pubmed.ncbi.nlm.nih.gov/17139284 DM2JE5F DI DM2JE5F DM2JE5F DN Cyclic LVVYPWT DM2JE5F MI TT2THBD DM2JE5F MN P2X purinoceptor 3 (P2RX3) DM2JE5F MT DTT DM2JE5F MA Inhibitor DM2JE5F RN Structure-activity relationship studies of spinorphin as a potent and selective human P2X(3) receptor antagonist. J Med Chem. 2007 Sep 6;50(18):4543-7. DM2JE5F RU https://pubmed.ncbi.nlm.nih.gov/17676725 DMFUG05 DI DMFUG05 DMFUG05 DN Cyclo(1,10)EIYDPGDDIK DMFUG05 MI TTJDUNO DMFUG05 MN T-cell surface antigen CD2 (CD2) DMFUG05 MT DTT DMFUG05 MA Inhibitor DMFUG05 RN Design of beta-hairpin peptides for modulation of cell adhesion by beta-turn constraint. J Med Chem. 2009 Feb 12;52(3):726-36. DMFUG05 RU https://pubmed.ncbi.nlm.nih.gov/19123855 DM5CBQ9 DI DM5CBQ9 DM5CBQ9 DN Cyclo(1,10)H-EIYDPGDDIK-OH DM5CBQ9 MI TTJDUNO DM5CBQ9 MN T-cell surface antigen CD2 (CD2) DM5CBQ9 MT DTT DM5CBQ9 MA Inhibitor DM5CBQ9 RN Design of beta-hairpin peptides for modulation of cell adhesion by beta-turn constraint. J Med Chem. 2009 Feb 12;52(3):726-36. DM5CBQ9 RU https://pubmed.ncbi.nlm.nih.gov/19123855 DM4A1TF DI DM4A1TF DM4A1TF DN Cyclo(1,11)H-ESIYDPGDDIK-OH DM4A1TF MI TTJDUNO DM4A1TF MN T-cell surface antigen CD2 (CD2) DM4A1TF MT DTT DM4A1TF MA Inhibitor DM4A1TF RN Design of beta-hairpin peptides for modulation of cell adhesion by beta-turn constraint. J Med Chem. 2009 Feb 12;52(3):726-36. DM4A1TF RU https://pubmed.ncbi.nlm.nih.gov/19123855 DMVDS8B DI DMVDS8B DMVDS8B DN Cyclo(1,12)PenIYDTKGKNVLC-OH DMVDS8B MI TTJDUNO DMVDS8B MN T-cell surface antigen CD2 (CD2) DMVDS8B MT DTT DMVDS8B MA Inhibitor DMVDS8B RN Structure-activity studies of peptides from the "hot-spot" region of human CD2 protein: development of peptides for immunomodulation. J Med Chem. 2005 Oct 6;48(20):6236-49. DMVDS8B RU https://pubmed.ncbi.nlm.nih.gov/16190751 DMLY8CU DI DMLY8CU DMLY8CU DN Cyclo(-D-Ala-D-Arg-L-Arg-L-Nal-Gly-) DMLY8CU MI TTBID49 DMLY8CU MN C-X-C chemokine receptor type 4 (CXCR4) DMLY8CU MT DTT DMLY8CU MA Inhibitor DMLY8CU RN Structure-activity relationships of cyclic peptide-based chemokine receptor CXCR4 antagonists: disclosing the importance of side-chain and backbone... J Med Chem. 2007 Jan 25;50(2):192-8. DMLY8CU RU https://pubmed.ncbi.nlm.nih.gov/17228861 DMBKRQ9 DI DMBKRQ9 DMBKRQ9 DN Cyclo(-D-MeTyr-D-Arg-L-Arg-L-Nal-Gly-) DMBKRQ9 MI TTBID49 DMBKRQ9 MN C-X-C chemokine receptor type 4 (CXCR4) DMBKRQ9 MT DTT DMBKRQ9 MA Inhibitor DMBKRQ9 RN Structure-activity relationships of cyclic peptide-based chemokine receptor CXCR4 antagonists: disclosing the importance of side-chain and backbone... J Med Chem. 2007 Jan 25;50(2):192-8. DMBKRQ9 RU https://pubmed.ncbi.nlm.nih.gov/17228861 DMHI0UL DI DMHI0UL DMHI0UL DN Cyclo(-D-MeTyr-L-Arg-L-Arg-L-Nal-Gly-) DMHI0UL MI TTBID49 DMHI0UL MN C-X-C chemokine receptor type 4 (CXCR4) DMHI0UL MT DTT DMHI0UL MA Inhibitor DMHI0UL RN Structure-activity relationships of cyclic peptide-based chemokine receptor CXCR4 antagonists: disclosing the importance of side-chain and backbone... J Med Chem. 2007 Jan 25;50(2):192-8. DMHI0UL RU https://pubmed.ncbi.nlm.nih.gov/17228861 DM82C6Q DI DM82C6Q DM82C6Q DN Cyclo(-D-Tyr-Arg-Arg-Nal-Gly-) DM82C6Q MI TTBID49 DM82C6Q MN C-X-C chemokine receptor type 4 (CXCR4) DM82C6Q MT DTT DM82C6Q MA Inhibitor DM82C6Q RN Identification of novel non-peptide CXCR4 antagonists by ligand-based design approach. Bioorg Med Chem Lett. 2008 Jul 15;18(14):4124-9. DM82C6Q RU https://pubmed.ncbi.nlm.nih.gov/18539453 DM8RKT1 DI DM8RKT1 DM8RKT1 DN Cyclo(-D-Tyr-D-Ala-L-Arg-L-Nal-Gly-) DM8RKT1 MI TTBID49 DM8RKT1 MN C-X-C chemokine receptor type 4 (CXCR4) DM8RKT1 MT DTT DM8RKT1 MA Inhibitor DM8RKT1 RN Structure-activity relationships of cyclic peptide-based chemokine receptor CXCR4 antagonists: disclosing the importance of side-chain and backbone... J Med Chem. 2007 Jan 25;50(2):192-8. DM8RKT1 RU https://pubmed.ncbi.nlm.nih.gov/17228861 DM8XVAW DI DM8XVAW DM8XVAW DN Cyclo(-D-Tyr-D-Arg-L-Arg-L-MeNal-Gly-) DM8XVAW MI TTBID49 DM8XVAW MN C-X-C chemokine receptor type 4 (CXCR4) DM8XVAW MT DTT DM8XVAW MA Inhibitor DM8XVAW RN Structure-activity relationships of cyclic peptide-based chemokine receptor CXCR4 antagonists: disclosing the importance of side-chain and backbone... J Med Chem. 2007 Jan 25;50(2):192-8. DM8XVAW RU https://pubmed.ncbi.nlm.nih.gov/17228861 DMWFITM DI DMWFITM DMWFITM DN Cyclo(-D-Tyr-D-Arg-L-Arg-L-Nal-beta-Ala-) DMWFITM MI TTBID49 DMWFITM MN C-X-C chemokine receptor type 4 (CXCR4) DMWFITM MT DTT DMWFITM MA Inhibitor DMWFITM RN Structure-activity relationships of cyclic peptide-based chemokine receptor CXCR4 antagonists: disclosing the importance of side-chain and backbone... J Med Chem. 2007 Jan 25;50(2):192-8. DMWFITM RU https://pubmed.ncbi.nlm.nih.gov/17228861 DMSA0IW DI DMSA0IW DMSA0IW DN Cyclo(-D-Tyr-D-Arg-L-Arg-L-Nal-D-Ala-) DMSA0IW MI TTBID49 DMSA0IW MN C-X-C chemokine receptor type 4 (CXCR4) DMSA0IW MT DTT DMSA0IW MA Inhibitor DMSA0IW RN Structure-activity relationships of cyclic peptide-based chemokine receptor CXCR4 antagonists: disclosing the importance of side-chain and backbone... J Med Chem. 2007 Jan 25;50(2):192-8. DMSA0IW RU https://pubmed.ncbi.nlm.nih.gov/17228861 DMGOW1E DI DMGOW1E DMGOW1E DN Cyclo(-D-Tyr-D-Arg-L-Arg-L-Nal-Gly-) DMGOW1E MI TTBID49 DMGOW1E MN C-X-C chemokine receptor type 4 (CXCR4) DMGOW1E MT DTT DMGOW1E MA Inhibitor DMGOW1E RN Structure-activity relationships of cyclic peptide-based chemokine receptor CXCR4 antagonists: disclosing the importance of side-chain and backbone... J Med Chem. 2007 Jan 25;50(2):192-8. DMGOW1E RU https://pubmed.ncbi.nlm.nih.gov/17228861 DM3PRHF DI DM3PRHF DM3PRHF DN Cyclo(-D-Tyr-D-Arg-L-Arg-L-Nal-L-Ala-) DM3PRHF MI TTBID49 DM3PRHF MN C-X-C chemokine receptor type 4 (CXCR4) DM3PRHF MT DTT DM3PRHF MA Inhibitor DM3PRHF RN Structure-activity relationships of cyclic peptide-based chemokine receptor CXCR4 antagonists: disclosing the importance of side-chain and backbone... J Med Chem. 2007 Jan 25;50(2):192-8. DM3PRHF RU https://pubmed.ncbi.nlm.nih.gov/17228861 DMS9QHI DI DMS9QHI DMS9QHI DN Cyclo(-D-Tyr-D-Arg-L-Arg-L-Nal-L-Pic-) DMS9QHI MI TTBID49 DMS9QHI MN C-X-C chemokine receptor type 4 (CXCR4) DMS9QHI MT DTT DMS9QHI MA Inhibitor DMS9QHI RN Structure-activity relationships of cyclic peptide-based chemokine receptor CXCR4 antagonists: disclosing the importance of side-chain and backbone... J Med Chem. 2007 Jan 25;50(2):192-8. DMS9QHI RU https://pubmed.ncbi.nlm.nih.gov/17228861 DM3Y1TZ DI DM3Y1TZ DM3Y1TZ DN Cyclo(-D-Tyr-D-Arg-L-Arg-L-Nal-Sar-) DM3Y1TZ MI TTBID49 DM3Y1TZ MN C-X-C chemokine receptor type 4 (CXCR4) DM3Y1TZ MT DTT DM3Y1TZ MA Inhibitor DM3Y1TZ RN Structure-activity relationships of cyclic peptide-based chemokine receptor CXCR4 antagonists: disclosing the importance of side-chain and backbone... J Med Chem. 2007 Jan 25;50(2):192-8. DM3Y1TZ RU https://pubmed.ncbi.nlm.nih.gov/17228861 DMUWC5O DI DMUWC5O DMUWC5O DN Cyclo(-D-Tyr-D-Arg-L-MeArg-L-Nal-Gly-) DMUWC5O MI TTBID49 DMUWC5O MN C-X-C chemokine receptor type 4 (CXCR4) DMUWC5O MT DTT DMUWC5O MA Inhibitor DMUWC5O RN Structure-activity relationships of cyclic peptide-based chemokine receptor CXCR4 antagonists: disclosing the importance of side-chain and backbone... J Med Chem. 2007 Jan 25;50(2):192-8. DMUWC5O RU https://pubmed.ncbi.nlm.nih.gov/17228861 DM8F5DY DI DM8F5DY DM8F5DY DN Cyclo(-D-Tyr-D-MeArg-L-Arg-L-Nal-Gly-) DM8F5DY MI TTBID49 DM8F5DY MN C-X-C chemokine receptor type 4 (CXCR4) DM8F5DY MT DTT DM8F5DY MA Inhibitor DM8F5DY RN Structure-activity relationships of cyclic peptide-based chemokine receptor CXCR4 antagonists: disclosing the importance of side-chain and backbone... J Med Chem. 2007 Jan 25;50(2):192-8. DM8F5DY RU https://pubmed.ncbi.nlm.nih.gov/17228861 DMPW9SD DI DMPW9SD DMPW9SD DN Cyclo(-D-Tyr-L-Ala-L-Arg-L-Nal-Gly-) DMPW9SD MI TTBID49 DMPW9SD MN C-X-C chemokine receptor type 4 (CXCR4) DMPW9SD MT DTT DMPW9SD MA Inhibitor DMPW9SD RN Structure-activity relationships of cyclic peptide-based chemokine receptor CXCR4 antagonists: disclosing the importance of side-chain and backbone... J Med Chem. 2007 Jan 25;50(2):192-8. DMPW9SD RU https://pubmed.ncbi.nlm.nih.gov/17228861 DMOWT4H DI DMOWT4H DMOWT4H DN Cyclo(-D-Tyr-L-Arg-L-Arg-L-Ala-Sar-) DMOWT4H MI TTBID49 DMOWT4H MN C-X-C chemokine receptor type 4 (CXCR4) DMOWT4H MT DTT DMOWT4H MA Inhibitor DMOWT4H RN Structure-activity relationships of cyclic peptide-based chemokine receptor CXCR4 antagonists: disclosing the importance of side-chain and backbone... J Med Chem. 2007 Jan 25;50(2):192-8. DMOWT4H RU https://pubmed.ncbi.nlm.nih.gov/17228861 DMPZ316 DI DMPZ316 DMPZ316 DN Cyclo(-D-Tyr-L-Arg-L-Arg-L-MeNal-Gly-) DMPZ316 MI TTBID49 DMPZ316 MN C-X-C chemokine receptor type 4 (CXCR4) DMPZ316 MT DTT DMPZ316 MA Inhibitor DMPZ316 RN Structure-activity relationships of cyclic peptide-based chemokine receptor CXCR4 antagonists: disclosing the importance of side-chain and backbone... J Med Chem. 2007 Jan 25;50(2):192-8. DMPZ316 RU https://pubmed.ncbi.nlm.nih.gov/17228861 DMNQWBS DI DMNQWBS DMNQWBS DN Cyclo(-D-Tyr-L-Arg-L-Arg-L-Nal-beta-Ala-) DMNQWBS MI TTBID49 DMNQWBS MN C-X-C chemokine receptor type 4 (CXCR4) DMNQWBS MT DTT DMNQWBS MA Inhibitor DMNQWBS RN Structure-activity relationships of cyclic peptide-based chemokine receptor CXCR4 antagonists: disclosing the importance of side-chain and backbone... J Med Chem. 2007 Jan 25;50(2):192-8. DMNQWBS RU https://pubmed.ncbi.nlm.nih.gov/17228861 DMV6C9N DI DMV6C9N DMV6C9N DN Cyclo(-D-Tyr-L-Arg-L-Arg-L-Nal-D-Ala-) DMV6C9N MI TTBID49 DMV6C9N MN C-X-C chemokine receptor type 4 (CXCR4) DMV6C9N MT DTT DMV6C9N MA Inhibitor DMV6C9N RN Structure-activity relationships of cyclic peptide-based chemokine receptor CXCR4 antagonists: disclosing the importance of side-chain and backbone... J Med Chem. 2007 Jan 25;50(2):192-8. DMV6C9N RU https://pubmed.ncbi.nlm.nih.gov/17228861 DMH9VMO DI DMH9VMO DMH9VMO DN Cyclo(-D-Tyr-L-Arg-L-Arg-L-Nal-Gly-) DMH9VMO MI TTBID49 DMH9VMO MN C-X-C chemokine receptor type 4 (CXCR4) DMH9VMO MT DTT DMH9VMO MA Inhibitor DMH9VMO RN Structure-activity relationships of cyclic peptide-based chemokine receptor CXCR4 antagonists: disclosing the importance of side-chain and backbone... J Med Chem. 2007 Jan 25;50(2):192-8. DMH9VMO RU https://pubmed.ncbi.nlm.nih.gov/17228861 DM72HW3 DI DM72HW3 DM72HW3 DN Cyclo(-D-Tyr-L-Arg-L-Arg-L-Nal-L-Ala-) DM72HW3 MI TTBID49 DM72HW3 MN C-X-C chemokine receptor type 4 (CXCR4) DM72HW3 MT DTT DM72HW3 MA Inhibitor DM72HW3 RN Structure-activity relationships of cyclic peptide-based chemokine receptor CXCR4 antagonists: disclosing the importance of side-chain and backbone... J Med Chem. 2007 Jan 25;50(2):192-8. DM72HW3 RU https://pubmed.ncbi.nlm.nih.gov/17228861 DMSPKWD DI DMSPKWD DMSPKWD DN Cyclo(-D-Tyr-L-Arg-L-MeArg-L-Nal-Gly-) DMSPKWD MI TTBID49 DMSPKWD MN C-X-C chemokine receptor type 4 (CXCR4) DMSPKWD MT DTT DMSPKWD MA Inhibitor DMSPKWD RN Structure-activity relationships of cyclic peptide-based chemokine receptor CXCR4 antagonists: disclosing the importance of side-chain and backbone... J Med Chem. 2007 Jan 25;50(2):192-8. DMSPKWD RU https://pubmed.ncbi.nlm.nih.gov/17228861 DMIUVQ6 DI DMIUVQ6 DMIUVQ6 DN Cyclo(-D-Tyr-L-MeArg-L-Arg-L-Nal-Gly-) DMIUVQ6 MI TTBID49 DMIUVQ6 MN C-X-C chemokine receptor type 4 (CXCR4) DMIUVQ6 MT DTT DMIUVQ6 MA Inhibitor DMIUVQ6 RN Structure-activity relationships of cyclic peptide-based chemokine receptor CXCR4 antagonists: disclosing the importance of side-chain and backbone... J Med Chem. 2007 Jan 25;50(2):192-8. DMIUVQ6 RU https://pubmed.ncbi.nlm.nih.gov/17228861 DMZF35W DI DMZF35W DMZF35W DN Cyclo(-L-Am7(S2Py)-A2in-L-Ala-D-Pro-) DMZF35W MI TT6R7JZ DMZF35W MN Histone deacetylase 1 (HDAC1) DMZF35W MT DTT DMZF35W MA Inhibitor DMZF35W RN Molecular design of histone deacetylase inhibitors by aromatic ring shifting in chlamydocin framework. Bioorg Med Chem. 2007 Dec 15;15(24):7830-9. DMZF35W RU https://pubmed.ncbi.nlm.nih.gov/17881232 DMZF35W DI DMZF35W DMZF35W DN Cyclo(-L-Am7(S2Py)-A2in-L-Ala-D-Pro-) DMZF35W MI TTTQGH8 DMZF35W MN Histone deacetylase 4 (HDAC4) DMZF35W MT DTT DMZF35W MA Inhibitor DMZF35W RN Molecular design of histone deacetylase inhibitors by aromatic ring shifting in chlamydocin framework. Bioorg Med Chem. 2007 Dec 15;15(24):7830-9. DMZF35W RU https://pubmed.ncbi.nlm.nih.gov/17881232 DMZF35W DI DMZF35W DMZF35W DN Cyclo(-L-Am7(S2Py)-A2in-L-Ala-D-Pro-) DMZF35W MI TT5ZKDI DMZF35W MN Histone deacetylase 6 (HDAC6) DMZF35W MT DTT DMZF35W MA Inhibitor DMZF35W RN Molecular design of histone deacetylase inhibitors by aromatic ring shifting in chlamydocin framework. Bioorg Med Chem. 2007 Dec 15;15(24):7830-9. DMZF35W RU https://pubmed.ncbi.nlm.nih.gov/17881232 DMIVREK DI DMIVREK DMIVREK DN Cyclo(-L-Am7(S2Py)-Aib-L-Ala-D-Pro-) DMIVREK MI TT6R7JZ DMIVREK MN Histone deacetylase 1 (HDAC1) DMIVREK MT DTT DMIVREK MA Inhibitor DMIVREK RN Molecular design of histone deacetylase inhibitors by aromatic ring shifting in chlamydocin framework. Bioorg Med Chem. 2007 Dec 15;15(24):7830-9. DMIVREK RU https://pubmed.ncbi.nlm.nih.gov/17881232 DMIVREK DI DMIVREK DMIVREK DN Cyclo(-L-Am7(S2Py)-Aib-L-Ala-D-Pro-) DMIVREK MI TTTQGH8 DMIVREK MN Histone deacetylase 4 (HDAC4) DMIVREK MT DTT DMIVREK MA Inhibitor DMIVREK RN Molecular design of histone deacetylase inhibitors by aromatic ring shifting in chlamydocin framework. Bioorg Med Chem. 2007 Dec 15;15(24):7830-9. DMIVREK RU https://pubmed.ncbi.nlm.nih.gov/17881232 DMIVREK DI DMIVREK DMIVREK DN Cyclo(-L-Am7(S2Py)-Aib-L-Ala-D-Pro-) DMIVREK MI TT5ZKDI DMIVREK MN Histone deacetylase 6 (HDAC6) DMIVREK MT DTT DMIVREK MA Inhibitor DMIVREK RN Molecular design of histone deacetylase inhibitors by aromatic ring shifting in chlamydocin framework. Bioorg Med Chem. 2007 Dec 15;15(24):7830-9. DMIVREK RU https://pubmed.ncbi.nlm.nih.gov/17881232 DMLBECR DI DMLBECR DMLBECR DN Cyclo(-L-Am7(S2Py)-Aib-L-Ala-D-Tic-) DMLBECR MI TT6R7JZ DMLBECR MN Histone deacetylase 1 (HDAC1) DMLBECR MT DTT DMLBECR MA Inhibitor DMLBECR RN Molecular design of histone deacetylase inhibitors by aromatic ring shifting in chlamydocin framework. Bioorg Med Chem. 2007 Dec 15;15(24):7830-9. DMLBECR RU https://pubmed.ncbi.nlm.nih.gov/17881232 DMLBECR DI DMLBECR DMLBECR DN Cyclo(-L-Am7(S2Py)-Aib-L-Ala-D-Tic-) DMLBECR MI TTTQGH8 DMLBECR MN Histone deacetylase 4 (HDAC4) DMLBECR MT DTT DMLBECR MA Inhibitor DMLBECR RN Molecular design of histone deacetylase inhibitors by aromatic ring shifting in chlamydocin framework. Bioorg Med Chem. 2007 Dec 15;15(24):7830-9. DMLBECR RU https://pubmed.ncbi.nlm.nih.gov/17881232 DMLBECR DI DMLBECR DMLBECR DN Cyclo(-L-Am7(S2Py)-Aib-L-Ala-D-Tic-) DMLBECR MI TT5ZKDI DMLBECR MN Histone deacetylase 6 (HDAC6) DMLBECR MT DTT DMLBECR MA Inhibitor DMLBECR RN Molecular design of histone deacetylase inhibitors by aromatic ring shifting in chlamydocin framework. Bioorg Med Chem. 2007 Dec 15;15(24):7830-9. DMLBECR RU https://pubmed.ncbi.nlm.nih.gov/17881232 DMA76KW DI DMA76KW DMA76KW DN Cyclo(-L-Am7(S2Py)-Aib-L-Ph4-D-Pro-) DMA76KW MI TT6R7JZ DMA76KW MN Histone deacetylase 1 (HDAC1) DMA76KW MT DTT DMA76KW MA Inhibitor DMA76KW RN Molecular design of histone deacetylase inhibitors by aromatic ring shifting in chlamydocin framework. Bioorg Med Chem. 2007 Dec 15;15(24):7830-9. DMA76KW RU https://pubmed.ncbi.nlm.nih.gov/17881232 DMA76KW DI DMA76KW DMA76KW DN Cyclo(-L-Am7(S2Py)-Aib-L-Ph4-D-Pro-) DMA76KW MI TTTQGH8 DMA76KW MN Histone deacetylase 4 (HDAC4) DMA76KW MT DTT DMA76KW MA Inhibitor DMA76KW RN Molecular design of histone deacetylase inhibitors by aromatic ring shifting in chlamydocin framework. Bioorg Med Chem. 2007 Dec 15;15(24):7830-9. DMA76KW RU https://pubmed.ncbi.nlm.nih.gov/17881232 DMA76KW DI DMA76KW DMA76KW DN Cyclo(-L-Am7(S2Py)-Aib-L-Ph4-D-Pro-) DMA76KW MI TT5ZKDI DMA76KW MN Histone deacetylase 6 (HDAC6) DMA76KW MT DTT DMA76KW MA Inhibitor DMA76KW RN Molecular design of histone deacetylase inhibitors by aromatic ring shifting in chlamydocin framework. Bioorg Med Chem. 2007 Dec 15;15(24):7830-9. DMA76KW RU https://pubmed.ncbi.nlm.nih.gov/17881232 DMLNJ0O DI DMLNJ0O DMLNJ0O DN Cyclo(-L-Am7(S2Py)-Aib-L-Ph5-D-Pro-) DMLNJ0O MI TT6R7JZ DMLNJ0O MN Histone deacetylase 1 (HDAC1) DMLNJ0O MT DTT DMLNJ0O MA Inhibitor DMLNJ0O RN Molecular design of histone deacetylase inhibitors by aromatic ring shifting in chlamydocin framework. Bioorg Med Chem. 2007 Dec 15;15(24):7830-9. DMLNJ0O RU https://pubmed.ncbi.nlm.nih.gov/17881232 DMLNJ0O DI DMLNJ0O DMLNJ0O DN Cyclo(-L-Am7(S2Py)-Aib-L-Ph5-D-Pro-) DMLNJ0O MI TTTQGH8 DMLNJ0O MN Histone deacetylase 4 (HDAC4) DMLNJ0O MT DTT DMLNJ0O MA Inhibitor DMLNJ0O RN Molecular design of histone deacetylase inhibitors by aromatic ring shifting in chlamydocin framework. Bioorg Med Chem. 2007 Dec 15;15(24):7830-9. DMLNJ0O RU https://pubmed.ncbi.nlm.nih.gov/17881232 DMLNJ0O DI DMLNJ0O DMLNJ0O DN Cyclo(-L-Am7(S2Py)-Aib-L-Ph5-D-Pro-) DMLNJ0O MI TT5ZKDI DMLNJ0O MN Histone deacetylase 6 (HDAC6) DMLNJ0O MT DTT DMLNJ0O MA Inhibitor DMLNJ0O RN Molecular design of histone deacetylase inhibitors by aromatic ring shifting in chlamydocin framework. Bioorg Med Chem. 2007 Dec 15;15(24):7830-9. DMLNJ0O RU https://pubmed.ncbi.nlm.nih.gov/17881232 DMTVMWA DI DMTVMWA DMTVMWA DN Cyclo(-L-Am7(S2Py)-Aib-L-Phe-D-Pro-) DMTVMWA MI TT6R7JZ DMTVMWA MN Histone deacetylase 1 (HDAC1) DMTVMWA MT DTT DMTVMWA MA Inhibitor DMTVMWA RN Molecular design of histone deacetylase inhibitors by aromatic ring shifting in chlamydocin framework. Bioorg Med Chem. 2007 Dec 15;15(24):7830-9. DMTVMWA RU https://pubmed.ncbi.nlm.nih.gov/17881232 DMTVMWA DI DMTVMWA DMTVMWA DN Cyclo(-L-Am7(S2Py)-Aib-L-Phe-D-Pro-) DMTVMWA MI TTTQGH8 DMTVMWA MN Histone deacetylase 4 (HDAC4) DMTVMWA MT DTT DMTVMWA MA Inhibitor DMTVMWA RN Molecular design of histone deacetylase inhibitors by aromatic ring shifting in chlamydocin framework. Bioorg Med Chem. 2007 Dec 15;15(24):7830-9. DMTVMWA RU https://pubmed.ncbi.nlm.nih.gov/17881232 DMTVMWA DI DMTVMWA DMTVMWA DN Cyclo(-L-Am7(S2Py)-Aib-L-Phe-D-Pro-) DMTVMWA MI TT5ZKDI DMTVMWA MN Histone deacetylase 6 (HDAC6) DMTVMWA MT DTT DMTVMWA MA Inhibitor DMTVMWA RN Molecular design of histone deacetylase inhibitors by aromatic ring shifting in chlamydocin framework. Bioorg Med Chem. 2007 Dec 15;15(24):7830-9. DMTVMWA RU https://pubmed.ncbi.nlm.nih.gov/17881232 DMUSEDF DI DMUSEDF DMUSEDF DN Cyclo(-L-Am7(S2Py)-Aib-L-Phg-D-Pro-) DMUSEDF MI TT6R7JZ DMUSEDF MN Histone deacetylase 1 (HDAC1) DMUSEDF MT DTT DMUSEDF MA Inhibitor DMUSEDF RN Molecular design of histone deacetylase inhibitors by aromatic ring shifting in chlamydocin framework. Bioorg Med Chem. 2007 Dec 15;15(24):7830-9. DMUSEDF RU https://pubmed.ncbi.nlm.nih.gov/17881232 DMUSEDF DI DMUSEDF DMUSEDF DN Cyclo(-L-Am7(S2Py)-Aib-L-Phg-D-Pro-) DMUSEDF MI TTTQGH8 DMUSEDF MN Histone deacetylase 4 (HDAC4) DMUSEDF MT DTT DMUSEDF MA Inhibitor DMUSEDF RN Molecular design of histone deacetylase inhibitors by aromatic ring shifting in chlamydocin framework. Bioorg Med Chem. 2007 Dec 15;15(24):7830-9. DMUSEDF RU https://pubmed.ncbi.nlm.nih.gov/17881232 DMUSEDF DI DMUSEDF DMUSEDF DN Cyclo(-L-Am7(S2Py)-Aib-L-Phg-D-Pro-) DMUSEDF MI TT5ZKDI DMUSEDF MN Histone deacetylase 6 (HDAC6) DMUSEDF MT DTT DMUSEDF MA Inhibitor DMUSEDF RN Molecular design of histone deacetylase inhibitors by aromatic ring shifting in chlamydocin framework. Bioorg Med Chem. 2007 Dec 15;15(24):7830-9. DMUSEDF RU https://pubmed.ncbi.nlm.nih.gov/17881232 DMSEQ0W DI DMSEQ0W DMSEQ0W DN Cyclo(-L-Am7(S2Py)-Aib-L-Ser(Bzl)-D-Pro-) DMSEQ0W MI TT6R7JZ DMSEQ0W MN Histone deacetylase 1 (HDAC1) DMSEQ0W MT DTT DMSEQ0W MA Inhibitor DMSEQ0W RN Molecular design of histone deacetylase inhibitors by aromatic ring shifting in chlamydocin framework. Bioorg Med Chem. 2007 Dec 15;15(24):7830-9. DMSEQ0W RU https://pubmed.ncbi.nlm.nih.gov/17881232 DMSEQ0W DI DMSEQ0W DMSEQ0W DN Cyclo(-L-Am7(S2Py)-Aib-L-Ser(Bzl)-D-Pro-) DMSEQ0W MI TTTQGH8 DMSEQ0W MN Histone deacetylase 4 (HDAC4) DMSEQ0W MT DTT DMSEQ0W MA Inhibitor DMSEQ0W RN Molecular design of histone deacetylase inhibitors by aromatic ring shifting in chlamydocin framework. Bioorg Med Chem. 2007 Dec 15;15(24):7830-9. DMSEQ0W RU https://pubmed.ncbi.nlm.nih.gov/17881232 DMSEQ0W DI DMSEQ0W DMSEQ0W DN Cyclo(-L-Am7(S2Py)-Aib-L-Ser(Bzl)-D-Pro-) DMSEQ0W MI TT5ZKDI DMSEQ0W MN Histone deacetylase 6 (HDAC6) DMSEQ0W MT DTT DMSEQ0W MA Inhibitor DMSEQ0W RN Molecular design of histone deacetylase inhibitors by aromatic ring shifting in chlamydocin framework. Bioorg Med Chem. 2007 Dec 15;15(24):7830-9. DMSEQ0W RU https://pubmed.ncbi.nlm.nih.gov/17881232 DMBKP48 DI DMBKP48 DMBKP48 DN Cyclo(-L-Am7(S2Py)-Aib-L-Ser-D-Pro-) DMBKP48 MI TT6R7JZ DMBKP48 MN Histone deacetylase 1 (HDAC1) DMBKP48 MT DTT DMBKP48 MA Inhibitor DMBKP48 RN Molecular design of histone deacetylase inhibitors by aromatic ring shifting in chlamydocin framework. Bioorg Med Chem. 2007 Dec 15;15(24):7830-9. DMBKP48 RU https://pubmed.ncbi.nlm.nih.gov/17881232 DMBKP48 DI DMBKP48 DMBKP48 DN Cyclo(-L-Am7(S2Py)-Aib-L-Ser-D-Pro-) DMBKP48 MI TTTQGH8 DMBKP48 MN Histone deacetylase 4 (HDAC4) DMBKP48 MT DTT DMBKP48 MA Inhibitor DMBKP48 RN Molecular design of histone deacetylase inhibitors by aromatic ring shifting in chlamydocin framework. Bioorg Med Chem. 2007 Dec 15;15(24):7830-9. DMBKP48 RU https://pubmed.ncbi.nlm.nih.gov/17881232 DMBKP48 DI DMBKP48 DMBKP48 DN Cyclo(-L-Am7(S2Py)-Aib-L-Ser-D-Pro-) DMBKP48 MI TT5ZKDI DMBKP48 MN Histone deacetylase 6 (HDAC6) DMBKP48 MT DTT DMBKP48 MA Inhibitor DMBKP48 RN Molecular design of histone deacetylase inhibitors by aromatic ring shifting in chlamydocin framework. Bioorg Med Chem. 2007 Dec 15;15(24):7830-9. DMBKP48 RU https://pubmed.ncbi.nlm.nih.gov/17881232 DMVY89X DI DMVY89X DMVY89X DN Cyclo(-L-Am7(S2Py)-D-2MePhe-L-Ala-D-Pro-) DMVY89X MI TT6R7JZ DMVY89X MN Histone deacetylase 1 (HDAC1) DMVY89X MT DTT DMVY89X MA Inhibitor DMVY89X RN Molecular design of histone deacetylase inhibitors by aromatic ring shifting in chlamydocin framework. Bioorg Med Chem. 2007 Dec 15;15(24):7830-9. DMVY89X RU https://pubmed.ncbi.nlm.nih.gov/17881232 DMVY89X DI DMVY89X DMVY89X DN Cyclo(-L-Am7(S2Py)-D-2MePhe-L-Ala-D-Pro-) DMVY89X MI TTTQGH8 DMVY89X MN Histone deacetylase 4 (HDAC4) DMVY89X MT DTT DMVY89X MA Inhibitor DMVY89X RN Molecular design of histone deacetylase inhibitors by aromatic ring shifting in chlamydocin framework. Bioorg Med Chem. 2007 Dec 15;15(24):7830-9. DMVY89X RU https://pubmed.ncbi.nlm.nih.gov/17881232 DMVY89X DI DMVY89X DMVY89X DN Cyclo(-L-Am7(S2Py)-D-2MePhe-L-Ala-D-Pro-) DMVY89X MI TT5ZKDI DMVY89X MN Histone deacetylase 6 (HDAC6) DMVY89X MT DTT DMVY89X MA Inhibitor DMVY89X RN Molecular design of histone deacetylase inhibitors by aromatic ring shifting in chlamydocin framework. Bioorg Med Chem. 2007 Dec 15;15(24):7830-9. DMVY89X RU https://pubmed.ncbi.nlm.nih.gov/17881232 DMTDIM9 DI DMTDIM9 DMTDIM9 DN Cyclo(-L-Am7(S2Py)-D-A1in-L-Ala-D-Pro-) DMTDIM9 MI TT6R7JZ DMTDIM9 MN Histone deacetylase 1 (HDAC1) DMTDIM9 MT DTT DMTDIM9 MA Inhibitor DMTDIM9 RN Molecular design of histone deacetylase inhibitors by aromatic ring shifting in chlamydocin framework. Bioorg Med Chem. 2007 Dec 15;15(24):7830-9. DMTDIM9 RU https://pubmed.ncbi.nlm.nih.gov/17881232 DMTDIM9 DI DMTDIM9 DMTDIM9 DN Cyclo(-L-Am7(S2Py)-D-A1in-L-Ala-D-Pro-) DMTDIM9 MI TTTQGH8 DMTDIM9 MN Histone deacetylase 4 (HDAC4) DMTDIM9 MT DTT DMTDIM9 MA Inhibitor DMTDIM9 RN Molecular design of histone deacetylase inhibitors by aromatic ring shifting in chlamydocin framework. Bioorg Med Chem. 2007 Dec 15;15(24):7830-9. DMTDIM9 RU https://pubmed.ncbi.nlm.nih.gov/17881232 DMTDIM9 DI DMTDIM9 DMTDIM9 DN Cyclo(-L-Am7(S2Py)-D-A1in-L-Ala-D-Pro-) DMTDIM9 MI TT5ZKDI DMTDIM9 MN Histone deacetylase 6 (HDAC6) DMTDIM9 MT DTT DMTDIM9 MA Inhibitor DMTDIM9 RN Molecular design of histone deacetylase inhibitors by aromatic ring shifting in chlamydocin framework. Bioorg Med Chem. 2007 Dec 15;15(24):7830-9. DMTDIM9 RU https://pubmed.ncbi.nlm.nih.gov/17881232 DMV23XD DI DMV23XD DMV23XD DN Cyclo(-L-Am7(S2Py)-L-2MePhe-L-Ala-D-Pro-) DMV23XD MI TT6R7JZ DMV23XD MN Histone deacetylase 1 (HDAC1) DMV23XD MT DTT DMV23XD MA Inhibitor DMV23XD RN Molecular design of histone deacetylase inhibitors by aromatic ring shifting in chlamydocin framework. Bioorg Med Chem. 2007 Dec 15;15(24):7830-9. DMV23XD RU https://pubmed.ncbi.nlm.nih.gov/17881232 DMV23XD DI DMV23XD DMV23XD DN Cyclo(-L-Am7(S2Py)-L-2MePhe-L-Ala-D-Pro-) DMV23XD MI TTTQGH8 DMV23XD MN Histone deacetylase 4 (HDAC4) DMV23XD MT DTT DMV23XD MA Inhibitor DMV23XD RN Molecular design of histone deacetylase inhibitors by aromatic ring shifting in chlamydocin framework. Bioorg Med Chem. 2007 Dec 15;15(24):7830-9. DMV23XD RU https://pubmed.ncbi.nlm.nih.gov/17881232 DMV23XD DI DMV23XD DMV23XD DN Cyclo(-L-Am7(S2Py)-L-2MePhe-L-Ala-D-Pro-) DMV23XD MI TT5ZKDI DMV23XD MN Histone deacetylase 6 (HDAC6) DMV23XD MT DTT DMV23XD MA Inhibitor DMV23XD RN Molecular design of histone deacetylase inhibitors by aromatic ring shifting in chlamydocin framework. Bioorg Med Chem. 2007 Dec 15;15(24):7830-9. DMV23XD RU https://pubmed.ncbi.nlm.nih.gov/17881232 DM0VIH4 DI DM0VIH4 DM0VIH4 DN Cyclo(-L-Am7(S2Py)-L-A1in-L-Ala-D-Pro-) DM0VIH4 MI TT6R7JZ DM0VIH4 MN Histone deacetylase 1 (HDAC1) DM0VIH4 MT DTT DM0VIH4 MA Inhibitor DM0VIH4 RN Molecular design of histone deacetylase inhibitors by aromatic ring shifting in chlamydocin framework. Bioorg Med Chem. 2007 Dec 15;15(24):7830-9. DM0VIH4 RU https://pubmed.ncbi.nlm.nih.gov/17881232 DM0VIH4 DI DM0VIH4 DM0VIH4 DN Cyclo(-L-Am7(S2Py)-L-A1in-L-Ala-D-Pro-) DM0VIH4 MI TTTQGH8 DM0VIH4 MN Histone deacetylase 4 (HDAC4) DM0VIH4 MT DTT DM0VIH4 MA Inhibitor DM0VIH4 RN Molecular design of histone deacetylase inhibitors by aromatic ring shifting in chlamydocin framework. Bioorg Med Chem. 2007 Dec 15;15(24):7830-9. DM0VIH4 RU https://pubmed.ncbi.nlm.nih.gov/17881232 DM0VIH4 DI DM0VIH4 DM0VIH4 DN Cyclo(-L-Am7(S2Py)-L-A1in-L-Ala-D-Pro-) DM0VIH4 MI TT5ZKDI DM0VIH4 MN Histone deacetylase 6 (HDAC6) DM0VIH4 MT DTT DM0VIH4 MA Inhibitor DM0VIH4 RN Molecular design of histone deacetylase inhibitors by aromatic ring shifting in chlamydocin framework. Bioorg Med Chem. 2007 Dec 15;15(24):7830-9. DM0VIH4 RU https://pubmed.ncbi.nlm.nih.gov/17881232 DM3QVOB DI DM3QVOB DM3QVOB DN Cyclo(RGDfV) (control) DM3QVOB MI TTT1R2L DM3QVOB MN Integrin alpha-V (ITGAV) DM3QVOB MT DTT DM3QVOB MA Inhibitor DM3QVOB RN Design, synthesis, and evaluation of near infrared fluorescent multimeric RGD peptides for targeting tumors. J Med Chem. 2006 Apr 6;49(7):2268-75. DM3QVOB RU https://pubmed.ncbi.nlm.nih.gov/16570923 DM3QVOB DI DM3QVOB DM3QVOB DN Cyclo(RGDfV) (control) DM3QVOB MI TTJA1ZO DM3QVOB MN ITGB3 messenger RNA (ITGB3 mRNA) DM3QVOB MT DTT DM3QVOB MA Inhibitor DM3QVOB RN Design, synthesis, and evaluation of near infrared fluorescent multimeric RGD peptides for targeting tumors. J Med Chem. 2006 Apr 6;49(7):2268-75. DM3QVOB RU https://pubmed.ncbi.nlm.nih.gov/16570923 DM9ZCWV DI DM9ZCWV DM9ZCWV DN Cyclo[(6-bromotryptophan)arginine] DM9ZCWV MI TTWJBZ5 DM9ZCWV MN 5-HT 2C receptor (HTR2C) DM9ZCWV MT DTT DM9ZCWV MA Inhibitor DM9ZCWV RN Brominated cyclodipeptides from the marine sponge Geodia barretti as selective 5-HT ligands. J Nat Prod. 2006 Oct;69(10):1421-4. DM9ZCWV RU https://pubmed.ncbi.nlm.nih.gov/17067154 DM67CAY DI DM67CAY DM67CAY DN Cyclo[Ac-Cys-Ile-Phe]-Lys-Tyr-Tyr DM67CAY MI TT6PKBN DM67CAY MN Proto-oncogene c-Src (SRC) DM67CAY MT DTT DM67CAY MA Inhibitor DM67CAY RN Synthesis and structure-activity relationships of linear and conformationally constrained peptide analogues of CIYKYY as Src tyrosine kinase inhibi... J Med Chem. 2006 Jun 1;49(11):3395-401. DM67CAY RU https://pubmed.ncbi.nlm.nih.gov/16722659 DMB2DV1 DI DMB2DV1 DMB2DV1 DN Cyclo[Ac-Cys-Ile-Tyr-Lys-Tyr-Phe] DMB2DV1 MI TT6PKBN DMB2DV1 MN Proto-oncogene c-Src (SRC) DMB2DV1 MT DTT DMB2DV1 MA Inhibitor DMB2DV1 RN Synthesis and structure-activity relationships of linear and conformationally constrained peptide analogues of CIYKYY as Src tyrosine kinase inhibi... J Med Chem. 2006 Jun 1;49(11):3395-401. DMB2DV1 RU https://pubmed.ncbi.nlm.nih.gov/16722659 DMO5V9M DI DMO5V9M DMO5V9M DN Cyclo[Ac-Cys-Ile-Tyr-Lys-Tyr-Tyr] DMO5V9M MI TT6PKBN DMO5V9M MN Proto-oncogene c-Src (SRC) DMO5V9M MT DTT DMO5V9M MA Inhibitor DMO5V9M RN Synthesis and structure-activity relationships of linear and conformationally constrained peptide analogues of CIYKYY as Src tyrosine kinase inhibi... J Med Chem. 2006 Jun 1;49(11):3395-401. DMO5V9M RU https://pubmed.ncbi.nlm.nih.gov/16722659 DMVXPUB DI DMVXPUB DMVXPUB DN Cyclo-[-Arg-Gly-Asp-Amp21-] DMVXPUB MI TTT1R2L DMVXPUB MN Integrin alpha-V (ITGAV) DMVXPUB MT DTT DMVXPUB MA Inhibitor DMVXPUB RN Discovery of subnanomolar arginine-glycine-aspartate-based alphaVbeta3/alphaVbeta5 integrin binders embedding 4-aminoproline residues. J Med Chem. 2008 Mar 27;51(6):1771-82. DMVXPUB RU https://pubmed.ncbi.nlm.nih.gov/18303826 DMVXPUB DI DMVXPUB DMVXPUB DN Cyclo-[-Arg-Gly-Asp-Amp21-] DMVXPUB MI TTJA1ZO DMVXPUB MN ITGB3 messenger RNA (ITGB3 mRNA) DMVXPUB MT DTT DMVXPUB MA Inhibitor DMVXPUB RN Discovery of subnanomolar arginine-glycine-aspartate-based alphaVbeta3/alphaVbeta5 integrin binders embedding 4-aminoproline residues. J Med Chem. 2008 Mar 27;51(6):1771-82. DMVXPUB RU https://pubmed.ncbi.nlm.nih.gov/18303826 DMBELJK DI DMBELJK DMBELJK DN Cyclo-[-Arg-Gly-Asp-Amp22-] DMBELJK MI TTT1R2L DMBELJK MN Integrin alpha-V (ITGAV) DMBELJK MT DTT DMBELJK MA Inhibitor DMBELJK RN Discovery of subnanomolar arginine-glycine-aspartate-based alphaVbeta3/alphaVbeta5 integrin binders embedding 4-aminoproline residues. J Med Chem. 2008 Mar 27;51(6):1771-82. DMBELJK RU https://pubmed.ncbi.nlm.nih.gov/18303826 DMBELJK DI DMBELJK DMBELJK DN Cyclo-[-Arg-Gly-Asp-Amp22-] DMBELJK MI TTJA1ZO DMBELJK MN ITGB3 messenger RNA (ITGB3 mRNA) DMBELJK MT DTT DMBELJK MA Inhibitor DMBELJK RN Discovery of subnanomolar arginine-glycine-aspartate-based alphaVbeta3/alphaVbeta5 integrin binders embedding 4-aminoproline residues. J Med Chem. 2008 Mar 27;51(6):1771-82. DMBELJK RU https://pubmed.ncbi.nlm.nih.gov/18303826 DMT29VJ DI DMT29VJ DMT29VJ DN Cyclo-[-Arg-Gly-Asp-Amp23-] DMT29VJ MI TTT1R2L DMT29VJ MN Integrin alpha-V (ITGAV) DMT29VJ MT DTT DMT29VJ MA Inhibitor DMT29VJ RN Discovery of subnanomolar arginine-glycine-aspartate-based alphaVbeta3/alphaVbeta5 integrin binders embedding 4-aminoproline residues. J Med Chem. 2008 Mar 27;51(6):1771-82. DMT29VJ RU https://pubmed.ncbi.nlm.nih.gov/18303826 DMT29VJ DI DMT29VJ DMT29VJ DN Cyclo-[-Arg-Gly-Asp-Amp23-] DMT29VJ MI TTJA1ZO DMT29VJ MN ITGB3 messenger RNA (ITGB3 mRNA) DMT29VJ MT DTT DMT29VJ MA Inhibitor DMT29VJ RN Discovery of subnanomolar arginine-glycine-aspartate-based alphaVbeta3/alphaVbeta5 integrin binders embedding 4-aminoproline residues. J Med Chem. 2008 Mar 27;51(6):1771-82. DMT29VJ RU https://pubmed.ncbi.nlm.nih.gov/18303826 DM35ZLK DI DM35ZLK DM35ZLK DN Cyclo-[-Arg-Gly-Asp-Amp24-] DM35ZLK MI TTT1R2L DM35ZLK MN Integrin alpha-V (ITGAV) DM35ZLK MT DTT DM35ZLK MA Inhibitor DM35ZLK RN Discovery of subnanomolar arginine-glycine-aspartate-based alphaVbeta3/alphaVbeta5 integrin binders embedding 4-aminoproline residues. J Med Chem. 2008 Mar 27;51(6):1771-82. DM35ZLK RU https://pubmed.ncbi.nlm.nih.gov/18303826 DM35ZLK DI DM35ZLK DM35ZLK DN Cyclo-[-Arg-Gly-Asp-Amp24-] DM35ZLK MI TTJA1ZO DM35ZLK MN ITGB3 messenger RNA (ITGB3 mRNA) DM35ZLK MT DTT DM35ZLK MA Inhibitor DM35ZLK RN Discovery of subnanomolar arginine-glycine-aspartate-based alphaVbeta3/alphaVbeta5 integrin binders embedding 4-aminoproline residues. J Med Chem. 2008 Mar 27;51(6):1771-82. DM35ZLK RU https://pubmed.ncbi.nlm.nih.gov/18303826 DMEIXUQ DI DMEIXUQ DMEIXUQ DN Cyclo-[-Arg-Gly-Asp-Amp25-] DMEIXUQ MI TTT1R2L DMEIXUQ MN Integrin alpha-V (ITGAV) DMEIXUQ MT DTT DMEIXUQ MA Inhibitor DMEIXUQ RN Discovery of subnanomolar arginine-glycine-aspartate-based alphaVbeta3/alphaVbeta5 integrin binders embedding 4-aminoproline residues. J Med Chem. 2008 Mar 27;51(6):1771-82. DMEIXUQ RU https://pubmed.ncbi.nlm.nih.gov/18303826 DMEIXUQ DI DMEIXUQ DMEIXUQ DN Cyclo-[-Arg-Gly-Asp-Amp25-] DMEIXUQ MI TTJA1ZO DMEIXUQ MN ITGB3 messenger RNA (ITGB3 mRNA) DMEIXUQ MT DTT DMEIXUQ MA Inhibitor DMEIXUQ RN Discovery of subnanomolar arginine-glycine-aspartate-based alphaVbeta3/alphaVbeta5 integrin binders embedding 4-aminoproline residues. J Med Chem. 2008 Mar 27;51(6):1771-82. DMEIXUQ RU https://pubmed.ncbi.nlm.nih.gov/18303826 DME5HRW DI DME5HRW DME5HRW DN Cyclo-[-Arg-Gly-Asp-Amp26-] DME5HRW MI TTT1R2L DME5HRW MN Integrin alpha-V (ITGAV) DME5HRW MT DTT DME5HRW MA Inhibitor DME5HRW RN Discovery of subnanomolar arginine-glycine-aspartate-based alphaVbeta3/alphaVbeta5 integrin binders embedding 4-aminoproline residues. J Med Chem. 2008 Mar 27;51(6):1771-82. DME5HRW RU https://pubmed.ncbi.nlm.nih.gov/18303826 DME5HRW DI DME5HRW DME5HRW DN Cyclo-[-Arg-Gly-Asp-Amp26-] DME5HRW MI TTJA1ZO DME5HRW MN ITGB3 messenger RNA (ITGB3 mRNA) DME5HRW MT DTT DME5HRW MA Inhibitor DME5HRW RN Discovery of subnanomolar arginine-glycine-aspartate-based alphaVbeta3/alphaVbeta5 integrin binders embedding 4-aminoproline residues. J Med Chem. 2008 Mar 27;51(6):1771-82. DME5HRW RU https://pubmed.ncbi.nlm.nih.gov/18303826 DMBNJZ0 DI DMBNJZ0 DMBNJZ0 DN Cyclo-[-Arg-Gly-Asp-Amp27-] DMBNJZ0 MI TTT1R2L DMBNJZ0 MN Integrin alpha-V (ITGAV) DMBNJZ0 MT DTT DMBNJZ0 MA Inhibitor DMBNJZ0 RN Discovery of subnanomolar arginine-glycine-aspartate-based alphaVbeta3/alphaVbeta5 integrin binders embedding 4-aminoproline residues. J Med Chem. 2008 Mar 27;51(6):1771-82. DMBNJZ0 RU https://pubmed.ncbi.nlm.nih.gov/18303826 DMBNJZ0 DI DMBNJZ0 DMBNJZ0 DN Cyclo-[-Arg-Gly-Asp-Amp27-] DMBNJZ0 MI TTJA1ZO DMBNJZ0 MN ITGB3 messenger RNA (ITGB3 mRNA) DMBNJZ0 MT DTT DMBNJZ0 MA Inhibitor DMBNJZ0 RN Discovery of subnanomolar arginine-glycine-aspartate-based alphaVbeta3/alphaVbeta5 integrin binders embedding 4-aminoproline residues. J Med Chem. 2008 Mar 27;51(6):1771-82. DMBNJZ0 RU https://pubmed.ncbi.nlm.nih.gov/18303826 DMJMHAV DI DMJMHAV DMJMHAV DN Cyclo-[-Arg-Gly-Asp-Amp28-] DMJMHAV MI TTT1R2L DMJMHAV MN Integrin alpha-V (ITGAV) DMJMHAV MT DTT DMJMHAV MA Inhibitor DMJMHAV RN Discovery of subnanomolar arginine-glycine-aspartate-based alphaVbeta3/alphaVbeta5 integrin binders embedding 4-aminoproline residues. J Med Chem. 2008 Mar 27;51(6):1771-82. DMJMHAV RU https://pubmed.ncbi.nlm.nih.gov/18303826 DMJMHAV DI DMJMHAV DMJMHAV DN Cyclo-[-Arg-Gly-Asp-Amp28-] DMJMHAV MI TTJA1ZO DMJMHAV MN ITGB3 messenger RNA (ITGB3 mRNA) DMJMHAV MT DTT DMJMHAV MA Inhibitor DMJMHAV RN Discovery of subnanomolar arginine-glycine-aspartate-based alphaVbeta3/alphaVbeta5 integrin binders embedding 4-aminoproline residues. J Med Chem. 2008 Mar 27;51(6):1771-82. DMJMHAV RU https://pubmed.ncbi.nlm.nih.gov/18303826 DMWD5RK DI DMWD5RK DMWD5RK DN Cyclo-[Asp6,Lys10]N/OFQ(1-13)NH2 DMWD5RK MI TTNT7K8 DMWD5RK MN Nociceptin receptor (OPRL1) DMWD5RK MT DTT DMWD5RK MA Inhibitor DMWD5RK RN High affinity conformationally constrained nociceptin/orphanin FQ(1-13) amide analogues. J Med Chem. 2008 Aug 14;51(15):4385-7. DMWD5RK RU https://pubmed.ncbi.nlm.nih.gov/18624395 DMSMH6T DI DMSMH6T DMSMH6T DN Cyclo[Cys6,Cys10]N/OFQ(1-13)NH2 DMSMH6T MI TTNT7K8 DMSMH6T MN Nociceptin receptor (OPRL1) DMSMH6T MT DTT DMSMH6T MA Inhibitor DMSMH6T RN High affinity conformationally constrained nociceptin/orphanin FQ(1-13) amide analogues. J Med Chem. 2008 Aug 14;51(15):4385-7. DMSMH6T RU https://pubmed.ncbi.nlm.nih.gov/18624395 DMI9C57 DI DMI9C57 DMI9C57 DN Cyclo[Cys7,Cys10]N/OFQ(1-13)NH2 DMI9C57 MI TTNT7K8 DMI9C57 MN Nociceptin receptor (OPRL1) DMI9C57 MT DTT DMI9C57 MA Inhibitor DMI9C57 RN High affinity conformationally constrained nociceptin/orphanin FQ(1-13) amide analogues. J Med Chem. 2008 Aug 14;51(15):4385-7. DMI9C57 RU https://pubmed.ncbi.nlm.nih.gov/18624395 DM39UMT DI DM39UMT DM39UMT DN Cyclo[DAsp7,Lys10]N/OFQ(1-13)NH2 DM39UMT MI TTNT7K8 DM39UMT MN Nociceptin receptor (OPRL1) DM39UMT MT DTT DM39UMT MA Inhibitor DM39UMT RN High affinity conformationally constrained nociceptin/orphanin FQ(1-13) amide analogues. J Med Chem. 2008 Aug 14;51(15):4385-7. DM39UMT RU https://pubmed.ncbi.nlm.nih.gov/18624395 DMWYFLD DI DMWYFLD DMWYFLD DN Cyclo[RGDfK(cypate)] DMWYFLD MI TTT1R2L DMWYFLD MN Integrin alpha-V (ITGAV) DMWYFLD MT DTT DMWYFLD MA Inhibitor DMWYFLD RN Design, synthesis, and evaluation of near infrared fluorescent multimeric RGD peptides for targeting tumors. J Med Chem. 2006 Apr 6;49(7):2268-75. DMWYFLD RU https://pubmed.ncbi.nlm.nih.gov/16570923 DMWYFLD DI DMWYFLD DMWYFLD DN Cyclo[RGDfK(cypate)] DMWYFLD MI TTJA1ZO DMWYFLD MN ITGB3 messenger RNA (ITGB3 mRNA) DMWYFLD MT DTT DMWYFLD MA Inhibitor DMWYFLD RN Design, synthesis, and evaluation of near infrared fluorescent multimeric RGD peptides for targeting tumors. J Med Chem. 2006 Apr 6;49(7):2268-75. DMWYFLD RU https://pubmed.ncbi.nlm.nih.gov/16570923 DM35PIJ DI DM35PIJ DM35PIJ DN Cyclobutyl DM35PIJ MI TTJS7O4 DM35PIJ MN Entamoeba Alcohol dehydrogenase 2 (Entamo ADH2) DM35PIJ MT DTT DM35PIJ MA Inhibitor DM35PIJ RN Entamoeba histolytica alcohol dehydrogenase 2 (EhADH2) as a target for anti-amoebic agents. J Antimicrob Chemother. 2004 Jul;54(1):56-9. DM35PIJ RU https://pubmed.ncbi.nlm.nih.gov/15150165 DMYLA7F DI DMYLA7F DMYLA7F DN Cyclobutylcarbamic Acid Biphenyl-3-yl Ester DMYLA7F MI TTDP1UC DMYLA7F MN Fatty acid amide hydrolase (FAAH) DMYLA7F MT DTT DMYLA7F MA Inhibitor DMYLA7F RN Synthesis and quantitative structure-activity relationship of fatty acid amide hydrolase inhibitors: modulation at the N-portion of biphenyl-3-yl a... J Med Chem. 2008 Jun 26;51(12):3487-98. DMYLA7F RU https://pubmed.ncbi.nlm.nih.gov/18507372 DMC520D DI DMC520D DMC520D DN Cycloguanil DMC520D MI TT9SL3Q DMC520D MN Polypeptide deformylase (PDF) DMC520D MT DTT DMC520D MA Inhibitor DMC520D RN Opportunities and challenges in antiparasitic drug discovery. Nat Rev Drug Discov. 2005 Sep;4(9):727-40. DMC520D RU https://pubmed.ncbi.nlm.nih.gov/16138106 DMGDA3C DI DMGDA3C DMGDA3C DN Cycloheximide DMGDA3C MI DTUGYRD DMGDA3C MN P-glycoprotein 1 (ABCB1) DMGDA3C MT DTP DMGDA3C MA Substrate DMGDA3C RN Carotenoids reverse multidrug resistance in cancer cells by interfering with ABC-transporters. Phytomedicine. 2012 Aug 15;19(11):977-87. DMGDA3C RU https://doi.org/10.1016/j.phymed.2012.05.010 DMZKH4R DI DMZKH4R DMZKH4R DN Cyclohexyl biphenyl-4-ylcarbamate DMZKH4R MI TTDP1UC DMZKH4R MN Fatty acid amide hydrolase (FAAH) DMZKH4R MT DTT DMZKH4R MA Inhibitor DMZKH4R RN The synthesis and biological evaluation of para-substituted phenolic N-alkyl carbamates as endocannabinoid hydrolyzing enzyme inhibitors. Eur J Med Chem. 2009 Jul;44(7):2994-3008. DMZKH4R RU https://pubmed.ncbi.nlm.nih.gov/19232787 DM84ZX5 DI DM84ZX5 DM84ZX5 DN Cyclohexyl-(2-phenoxy-9H-purin-6-yl)-amine DM84ZX5 MI TTM2AOE DM84ZX5 MN Adenosine A2a receptor (ADORA2A) DM84ZX5 MT DTT DM84ZX5 MA Inhibitor DM84ZX5 RN Reversine and its 2-substituted adenine derivatives as potent and selective A3 adenosine receptor antagonists. J Med Chem. 2005 Jul 28;48(15):4910-8. DM84ZX5 RU https://pubmed.ncbi.nlm.nih.gov/16033270 DM84ZX5 DI DM84ZX5 DM84ZX5 DN Cyclohexyl-(2-phenoxy-9H-purin-6-yl)-amine DM84ZX5 MI TTJFY5U DM84ZX5 MN Adenosine A3 receptor (ADORA3) DM84ZX5 MT DTT DM84ZX5 MA Inhibitor DM84ZX5 RN Reversine and its 2-substituted adenine derivatives as potent and selective A3 adenosine receptor antagonists. J Med Chem. 2005 Jul 28;48(15):4910-8. DM84ZX5 RU https://pubmed.ncbi.nlm.nih.gov/16033270 DMLREDJ DI DMLREDJ DMLREDJ DN Cyclohexyl-(2-phenylsulfanyl-9H-purin-6-yl)-amine DMLREDJ MI TTK25J1 DMLREDJ MN Adenosine A1 receptor (ADORA1) DMLREDJ MT DTT DMLREDJ MA Inhibitor DMLREDJ RN Reversine and its 2-substituted adenine derivatives as potent and selective A3 adenosine receptor antagonists. J Med Chem. 2005 Jul 28;48(15):4910-8. DMLREDJ RU https://pubmed.ncbi.nlm.nih.gov/16033270 DMLREDJ DI DMLREDJ DMLREDJ DN Cyclohexyl-(2-phenylsulfanyl-9H-purin-6-yl)-amine DMLREDJ MI TTM2AOE DMLREDJ MN Adenosine A2a receptor (ADORA2A) DMLREDJ MT DTT DMLREDJ MA Inhibitor DMLREDJ RN Reversine and its 2-substituted adenine derivatives as potent and selective A3 adenosine receptor antagonists. J Med Chem. 2005 Jul 28;48(15):4910-8. DMLREDJ RU https://pubmed.ncbi.nlm.nih.gov/16033270 DMLREDJ DI DMLREDJ DMLREDJ DN Cyclohexyl-(2-phenylsulfanyl-9H-purin-6-yl)-amine DMLREDJ MI TTJFY5U DMLREDJ MN Adenosine A3 receptor (ADORA3) DMLREDJ MT DTT DMLREDJ MA Inhibitor DMLREDJ RN Reversine and its 2-substituted adenine derivatives as potent and selective A3 adenosine receptor antagonists. J Med Chem. 2005 Jul 28;48(15):4910-8. DMLREDJ RU https://pubmed.ncbi.nlm.nih.gov/16033270 DMJEN45 DI DMJEN45 DMJEN45 DN Cyclohexyl-(3,4-dichloro-phenyl)-acetonitrile DMJEN45 MI TT3ROYC DMJEN45 MN Serotonin transporter (SERT) DMJEN45 MT DTT DMJEN45 MA Inhibitor DMJEN45 RN Synthesis and evaluation of dopamine and serotonin transporter inhibition by oxacyclic and carbacyclic analogues of methylphenidate. J Med Chem. 2003 Apr 10;46(8):1538-45. DMJEN45 RU https://pubmed.ncbi.nlm.nih.gov/12672255 DM1F7I5 DI DM1F7I5 DM1F7I5 DN Cyclohexyl-(9-ethyl-9H-purin-6-yl)-amine DM1F7I5 MI TTK25J1 DM1F7I5 MN Adenosine A1 receptor (ADORA1) DM1F7I5 MT DTT DM1F7I5 MA Inhibitor DM1F7I5 RN N6,9-disubstituted adenines: potent, selective antagonists at the A1 adenosine receptor. J Med Chem. 1991 Sep;34(9):2877-82. DM1F7I5 RU https://pubmed.ncbi.nlm.nih.gov/1895305 DMIUCSW DI DMIUCSW DMIUCSW DN Cyclohexyl-(9-methyl-9H-purin-6-yl)-amine DMIUCSW MI TTK25J1 DMIUCSW MN Adenosine A1 receptor (ADORA1) DMIUCSW MT DTT DMIUCSW MA Inhibitor DMIUCSW RN N6,9-disubstituted adenines: potent, selective antagonists at the A1 adenosine receptor. J Med Chem. 1991 Sep;34(9):2877-82. DMIUCSW RU https://pubmed.ncbi.nlm.nih.gov/1895305 DMYQH2N DI DMYQH2N DMYQH2N DN Cyclohexylammonium Ion DMYQH2N MI TTICX3S DMYQH2N MN Bacterial UDP-N-acetylglucosamine carboxyvinyltransferase (Bact murA) DMYQH2N MT DTT DMYQH2N MA Inhibitor DMYQH2N RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMYQH2N RU https://pubmed.ncbi.nlm.nih.gov/17139284 DM06OLY DI DM06OLY DM06OLY DN Cyclohexylcarbamic acidbiphenyl-3-yl ester DM06OLY MI TTDP1UC DM06OLY MN Fatty acid amide hydrolase (FAAH) DM06OLY MT DTT DM06OLY MA Inhibitor DM06OLY RN Synthesis and quantitative structure-activity relationship of fatty acid amide hydrolase inhibitors: modulation at the N-portion of biphenyl-3-yl a... J Med Chem. 2008 Jun 26;51(12):3487-98. DM06OLY RU https://pubmed.ncbi.nlm.nih.gov/18507372 DMNG4B1 DI DMNG4B1 DMNG4B1 DN Cyclohexylglycine-(2S)-cyanopyrrolidine DMNG4B1 MI TTDIGC1 DMNG4B1 MN Dipeptidyl peptidase 4 (DPP-4) DMNG4B1 MT DTT DMNG4B1 MA Inhibitor DMNG4B1 RN 2-[3-[2-[(2S)-2-Cyano-1-pyrrolidinyl]-2-oxoethylamino]-3-methyl-1-oxobutyl]- 1,2,3,4-tetrahydroisoquinoline: a potent, selective, and orally bioava... J Med Chem. 2006 Jan 12;49(1):373-80. DMNG4B1 RU https://pubmed.ncbi.nlm.nih.gov/16392822 DMEW7AY DI DMEW7AY DMEW7AY DN Cyclohexylmethylcarbamic Acid Biphenyl-3-yl Ester DMEW7AY MI TTDP1UC DMEW7AY MN Fatty acid amide hydrolase (FAAH) DMEW7AY MT DTT DMEW7AY MA Inhibitor DMEW7AY RN Synthesis and quantitative structure-activity relationship of fatty acid amide hydrolase inhibitors: modulation at the N-portion of biphenyl-3-yl a... J Med Chem. 2008 Jun 26;51(12):3487-98. DMEW7AY RU https://pubmed.ncbi.nlm.nih.gov/18507372 DM0L6E1 DI DM0L6E1 DM0L6E1 DN Cycloleucine DM0L6E1 MI TTLD29N DM0L6E1 MN Glutamate receptor ionotropic NMDA 1 (NMDAR1) DM0L6E1 MT DTT DM0L6E1 MA Inhibitor DM0L6E1 RN Effects of D-cycloserine and cycloleucine, ligands for the NMDA-associated strychnine-insensitive glycine site, on brain-stimulation reward and spontaneous locomotion. Pharmacol Biochem Behav. 1990 Aug;36(4):735-8. DM0L6E1 RU https://pubmed.ncbi.nlm.nih.gov/2170997 DMEM2SW DI DMEM2SW DMEM2SW DN CYCLOPAMINE DMEM2SW MI TT8J1S3 DMEM2SW MN Smoothened homolog (SMO) DMEM2SW MT DTT DMEM2SW MA Inhibitor DMEM2SW RN Identification and structure-activity relationships of ortho-biphenyl carboxamides as potent Smoothened antagonists inhibiting the Hedgehog signali... Bioorg Med Chem Lett. 2009 Jan 15;19(2):328-31. DMEM2SW RU https://pubmed.ncbi.nlm.nih.gov/19091559 DM78PR5 DI DM78PR5 DM78PR5 DN Cyclopentane amide derivatives 1 DM78PR5 MI TT50QJ3 DM78PR5 MN Influenza Neuraminidase (Influ NA) DM78PR5 MT DTT DM78PR5 MA Inhibitor DM78PR5 RN Antiviral agents active against influenza A viruses. Nat Rev Drug Discov. 2006 Dec;5(12):1015-25. DM78PR5 RU https://pubmed.ncbi.nlm.nih.gov/17139286 DMGU97P DI DMGU97P DMGU97P DN Cyclopentane amide derivatives 2 DMGU97P MI TT50QJ3 DMGU97P MN Influenza Neuraminidase (Influ NA) DMGU97P MT DTT DMGU97P MA Inhibitor DMGU97P RN Antiviral agents active against influenza A viruses. Nat Rev Drug Discov. 2006 Dec;5(12):1015-25. DMGU97P RU https://pubmed.ncbi.nlm.nih.gov/17139286 DMHTVRL DI DMHTVRL DMHTVRL DN Cyclopentane amide derivatives 3 DMHTVRL MI TT50QJ3 DMHTVRL MN Influenza Neuraminidase (Influ NA) DMHTVRL MT DTT DMHTVRL MA Inhibitor DMHTVRL RN Antiviral agents active against influenza A viruses. Nat Rev Drug Discov. 2006 Dec;5(12):1015-25. DMHTVRL RU https://pubmed.ncbi.nlm.nih.gov/17139286 DMOA7EP DI DMOA7EP DMOA7EP DN Cyclopentane amide derivatives 4 DMOA7EP MI TT50QJ3 DMOA7EP MN Influenza Neuraminidase (Influ NA) DMOA7EP MT DTT DMOA7EP MA Inhibitor DMOA7EP RN Antiviral agents active against influenza A viruses. Nat Rev Drug Discov. 2006 Dec;5(12):1015-25. DMOA7EP RU https://pubmed.ncbi.nlm.nih.gov/17139286 DMMV2LN DI DMMV2LN DMMV2LN DN Cyclopentyl 10H-phenothiazine-10-carboxylate DMMV2LN MI TTEB0GD DMMV2LN MN Cholinesterase (BCHE) DMMV2LN MT DTT DMMV2LN MA Inhibitor DMMV2LN RN Carbamates with differential mechanism of inhibition toward acetylcholinesterase and butyrylcholinesterase. J Med Chem. 2008 Jul 24;51(14):4200-12. DMMV2LN RU https://pubmed.ncbi.nlm.nih.gov/18570368 DMAKT65 DI DMAKT65 DMAKT65 DN Cyclopentyl-(3,4-dichloro-phenyl)-acetonitrile DMAKT65 MI TT3ROYC DMAKT65 MN Serotonin transporter (SERT) DMAKT65 MT DTT DMAKT65 MA Inhibitor DMAKT65 RN Synthesis and evaluation of dopamine and serotonin transporter inhibition by oxacyclic and carbacyclic analogues of methylphenidate. J Med Chem. 2003 Apr 10;46(8):1538-45. DMAKT65 RU https://pubmed.ncbi.nlm.nih.gov/12672255 DM0J9I5 DI DM0J9I5 DM0J9I5 DN Cyclopentyl(5-(pyridin-2-yl)oxazol-2-yl)methanone DM0J9I5 MI TTDP1UC DM0J9I5 MN Fatty acid amide hydrolase (FAAH) DM0J9I5 MT DTT DM0J9I5 MA Inhibitor DM0J9I5 RN Structure-activity relationships of alpha-ketooxazole inhibitors of fatty acid amide hydrolase. J Med Chem. 2007 Jul 12;50(14):3359-68. DM0J9I5 RU https://pubmed.ncbi.nlm.nih.gov/17559203 DMBDTFQ DI DMBDTFQ DMBDTFQ DN Cyclopentyl-(9-cyclopentyl-9H-purin-6-yl)-amine DMBDTFQ MI TTK25J1 DMBDTFQ MN Adenosine A1 receptor (ADORA1) DMBDTFQ MT DTT DMBDTFQ MA Inhibitor DMBDTFQ RN N6,9-disubstituted adenines: potent, selective antagonists at the A1 adenosine receptor. J Med Chem. 1991 Sep;34(9):2877-82. DMBDTFQ RU https://pubmed.ncbi.nlm.nih.gov/1895305 DMQ6BS2 DI DMQ6BS2 DMQ6BS2 DN Cyclopentyl-(9-ethyl-9H-purin-6-yl)-amine DMQ6BS2 MI TTK25J1 DMQ6BS2 MN Adenosine A1 receptor (ADORA1) DMQ6BS2 MT DTT DMQ6BS2 MA Inhibitor DMQ6BS2 RN N6,9-disubstituted adenines: potent, selective antagonists at the A1 adenosine receptor. J Med Chem. 1991 Sep;34(9):2877-82. DMQ6BS2 RU https://pubmed.ncbi.nlm.nih.gov/1895305 DM9DHNZ DI DM9DHNZ DM9DHNZ DN Cyclopentyl-(9-methyl-9H-purin-6-yl)-amine DM9DHNZ MI TTK25J1 DM9DHNZ MN Adenosine A1 receptor (ADORA1) DM9DHNZ MT DTT DM9DHNZ MA Inhibitor DM9DHNZ RN N6,9-disubstituted adenines: potent, selective antagonists at the A1 adenosine receptor. J Med Chem. 1991 Sep;34(9):2877-82. DM9DHNZ RU https://pubmed.ncbi.nlm.nih.gov/1895305 DMBJV90 DI DMBJV90 DMBJV90 DN Cyclopentyl-(9-phenyl-9H-purin-6-yl)-amine DMBJV90 MI TTK25J1 DMBJV90 MN Adenosine A1 receptor (ADORA1) DMBJV90 MT DTT DMBJV90 MA Inhibitor DMBJV90 RN N6,9-disubstituted adenines: potent, selective antagonists at the A1 adenosine receptor. J Med Chem. 1991 Sep;34(9):2877-82. DMBJV90 RU https://pubmed.ncbi.nlm.nih.gov/1895305 DMQLGFH DI DMQLGFH DMQLGFH DN Cyclopentylcarbamic Acid Biphenyl-3-yl Ester DMQLGFH MI TTDP1UC DMQLGFH MN Fatty acid amide hydrolase (FAAH) DMQLGFH MT DTT DMQLGFH MA Inhibitor DMQLGFH RN Synthesis and quantitative structure-activity relationship of fatty acid amide hydrolase inhibitors: modulation at the N-portion of biphenyl-3-yl a... J Med Chem. 2008 Jun 26;51(12):3487-98. DMQLGFH RU https://pubmed.ncbi.nlm.nih.gov/18507372 DM4KZ1W DI DM4KZ1W DM4KZ1W DN Cyclopentylcytosine DM4KZ1W MI TTN12BZ DM4KZ1W MN CTP synthase (CTPS1) DM4KZ1W MT DTT DM4KZ1W MA Inhibitor DM4KZ1W RN Molecular approaches for the treatment of hemorrhagic fever virus infections. Antiviral Res. 1993 Sep;22(1):45-75. DM4KZ1W RU https://pubmed.ncbi.nlm.nih.gov/8250543 DMPJ08G DI DMPJ08G DMPJ08G DN Cyclopiazonic acid DMPJ08G MI TTZVSJ2 DMPJ08G MN Sarcoplasmic/endoplasmic reticulum calcium ATPase (ATP2A) DMPJ08G MT DTT DMPJ08G MA Inhibitor DMPJ08G RN Expression and functional characterization of a Plasmodium falciparum Ca2+-ATPase (PfATP4) belonging to a subclass unique to apicomplexan organisms. J Biol Chem. 2001 Apr 6;276(14):10782-7. DMPJ08G RU https://pubmed.ncbi.nlm.nih.gov/11145964 DMGFEPJ DI DMGFEPJ DMGFEPJ DN Cyclopropyl DMGFEPJ MI TTJS7O4 DMGFEPJ MN Entamoeba Alcohol dehydrogenase 2 (Entamo ADH2) DMGFEPJ MT DTT DMGFEPJ MA Inhibitor DMGFEPJ RN Entamoeba histolytica alcohol dehydrogenase 2 (EhADH2) as a target for anti-amoebic agents. J Antimicrob Chemother. 2004 Jul;54(1):56-9. DMGFEPJ RU https://pubmed.ncbi.nlm.nih.gov/15150165 DMGZ0KM DI DMGZ0KM DMGZ0KM DN Cyclorgdfv DMGZ0KM MI TTT1R2L DMGZ0KM MN Integrin alpha-V (ITGAV) DMGZ0KM MT DTT DMGZ0KM MA Inhibitor DMGZ0KM RN Antiangiogenic effect of dual/selective alpha(5)beta(1)/alpha(v)beta(3) integrin antagonists designed on partially modified retro-inverso cyclotetr... J Med Chem. 2010 Jan 14;53(1):106-18. DMGZ0KM RU https://pubmed.ncbi.nlm.nih.gov/20055426 DMGZ0KM DI DMGZ0KM DMGZ0KM DN Cyclorgdfv DMGZ0KM MI TTJA1ZO DMGZ0KM MN ITGB3 messenger RNA (ITGB3 mRNA) DMGZ0KM MT DTT DMGZ0KM MA Inhibitor DMGZ0KM RN Antiangiogenic effect of dual/selective alpha(5)beta(1)/alpha(v)beta(3) integrin antagonists designed on partially modified retro-inverso cyclotetr... J Med Chem. 2010 Jan 14;53(1):106-18. DMGZ0KM RU https://pubmed.ncbi.nlm.nih.gov/20055426 DMB1U8V DI DMB1U8V DMB1U8V DN CYCLORPHAN DMB1U8V MI TT27RFC DMB1U8V MN Opioid receptor delta (OPRD1) DMB1U8V MT DTT DMB1U8V MA Inhibitor DMB1U8V RN Synthesis and opioid receptor binding affinities of 2-substituted and 3-aminomorphinans: ligands for mu, kappa, and delta opioid receptors. J Med Chem. 2010 Jan 14;53(1):402-18. DMB1U8V RU https://pubmed.ncbi.nlm.nih.gov/19928862 DMB1U8V DI DMB1U8V DMB1U8V DN CYCLORPHAN DMB1U8V MI TTQW87Y DMB1U8V MN Opioid receptor kappa (OPRK1) DMB1U8V MT DTT DMB1U8V MA Inhibitor DMB1U8V RN Synthesis and opioid receptor affinity of morphinan and benzomorphan derivatives: mixed kappa agonists and mu agonists/antagonists as potential pha... J Med Chem. 2000 Jan 13;43(1):114-22. DMB1U8V RU https://pubmed.ncbi.nlm.nih.gov/10633042 DMB1U8V DI DMB1U8V DMB1U8V DN CYCLORPHAN DMB1U8V MI TTKWM86 DMB1U8V MN Opioid receptor mu (MOP) DMB1U8V MT DTT DMB1U8V MA Inhibitor DMB1U8V RN Synthesis and opioid receptor affinity of morphinan and benzomorphan derivatives: mixed kappa agonists and mu agonists/antagonists as potential pha... J Med Chem. 2000 Jan 13;43(1):114-22. DMB1U8V RU https://pubmed.ncbi.nlm.nih.gov/10633042 DMLC041 DI DMLC041 DMLC041 DN Cyclosal-d4TMP DMLC041 MI TTEB0GD DMLC041 MN Cholinesterase (BCHE) DMLC041 MT DTT DMLC041 MA Inhibitor DMLC041 RN Bis-cycloSal-d4T-monophosphates: drugs that deliver two molecules of bioactive nucleotides. J Med Chem. 2007 Mar 22;50(6):1335-46. DMLC041 RU https://pubmed.ncbi.nlm.nih.gov/17328534 DMFTDPQ DI DMFTDPQ DMFTDPQ DN Cyclostellettamine derivative DMFTDPQ MI TTBH0VX DMFTDPQ MN Histone deacetylase (HDAC) DMFTDPQ MT DTT DMFTDPQ MA Inhibitor DMFTDPQ RN Three new cyclostellettamines, which inhibit histone deacetylase, from a marine sponge of the genus Xestospongia. Bioorg Med Chem Lett. 2004 May 17;14(10):2617-20. DMFTDPQ RU https://pubmed.ncbi.nlm.nih.gov/15109664 DMFTDPQ DI DMFTDPQ DMFTDPQ DN Cyclostellettamine derivative DMFTDPQ MI TT6R7JZ DMFTDPQ MN Histone deacetylase 1 (HDAC1) DMFTDPQ MT DTT DMFTDPQ MA Inhibitor DMFTDPQ RN Three new cyclostellettamines, which inhibit histone deacetylase, from a marine sponge of the genus Xestospongia. Bioorg Med Chem Lett. 2004 May 17;14(10):2617-20. DMFTDPQ RU https://pubmed.ncbi.nlm.nih.gov/15109664 DMFTDPQ DI DMFTDPQ DMFTDPQ DN Cyclostellettamine derivative DMFTDPQ MI TTYHPU6 DMFTDPQ MN Histone deacetylase 10 (HDAC10) DMFTDPQ MT DTT DMFTDPQ MA Inhibitor DMFTDPQ RN Three new cyclostellettamines, which inhibit histone deacetylase, from a marine sponge of the genus Xestospongia. Bioorg Med Chem Lett. 2004 May 17;14(10):2617-20. DMFTDPQ RU https://pubmed.ncbi.nlm.nih.gov/15109664 DMFTDPQ DI DMFTDPQ DMFTDPQ DN Cyclostellettamine derivative DMFTDPQ MI TTSHTOI DMFTDPQ MN Histone deacetylase 2 (HDAC2) DMFTDPQ MT DTT DMFTDPQ MA Inhibitor DMFTDPQ RN Three new cyclostellettamines, which inhibit histone deacetylase, from a marine sponge of the genus Xestospongia. Bioorg Med Chem Lett. 2004 May 17;14(10):2617-20. DMFTDPQ RU https://pubmed.ncbi.nlm.nih.gov/15109664 DMFTDPQ DI DMFTDPQ DMFTDPQ DN Cyclostellettamine derivative DMFTDPQ MI TTTQGH8 DMFTDPQ MN Histone deacetylase 4 (HDAC4) DMFTDPQ MT DTT DMFTDPQ MA Inhibitor DMFTDPQ RN Three new cyclostellettamines, which inhibit histone deacetylase, from a marine sponge of the genus Xestospongia. Bioorg Med Chem Lett. 2004 May 17;14(10):2617-20. DMFTDPQ RU https://pubmed.ncbi.nlm.nih.gov/15109664 DMFTDPQ DI DMFTDPQ DMFTDPQ DN Cyclostellettamine derivative DMFTDPQ MI TT5ZKDI DMFTDPQ MN Histone deacetylase 6 (HDAC6) DMFTDPQ MT DTT DMFTDPQ MA Inhibitor DMFTDPQ RN Three new cyclostellettamines, which inhibit histone deacetylase, from a marine sponge of the genus Xestospongia. Bioorg Med Chem Lett. 2004 May 17;14(10):2617-20. DMFTDPQ RU https://pubmed.ncbi.nlm.nih.gov/15109664 DMFTDPQ DI DMFTDPQ DMFTDPQ DN Cyclostellettamine derivative DMFTDPQ MI TTT6LFV DMFTDPQ MN Histone deacetylase 8 (HDAC8) DMFTDPQ MT DTT DMFTDPQ MA Inhibitor DMFTDPQ RN Three new cyclostellettamines, which inhibit histone deacetylase, from a marine sponge of the genus Xestospongia. Bioorg Med Chem Lett. 2004 May 17;14(10):2617-20. DMFTDPQ RU https://pubmed.ncbi.nlm.nih.gov/15109664 DM8HG0K DI DM8HG0K DM8HG0K DN Cyclotheonamide E DM8HG0K MI TT6L509 DM8HG0K MN Coagulation factor IIa (F2) DM8HG0K MT DTT DM8HG0K MA Inhibitor DM8HG0K RN Cyclotheonamide E4 and E5, new potent tryptase inhibitors from an Ircinia species of sponge. J Nat Prod. 2002 Mar;65(3):259-61. DM8HG0K RU https://pubmed.ncbi.nlm.nih.gov/11908961 DM2E5VZ DI DM2E5VZ DM2E5VZ DN Cyclotheonamide E4 DM2E5VZ MI TT6L509 DM2E5VZ MN Coagulation factor IIa (F2) DM2E5VZ MT DTT DM2E5VZ MA Inhibitor DM2E5VZ RN Cyclotheonamide E4 and E5, new potent tryptase inhibitors from an Ircinia species of sponge. J Nat Prod. 2002 Mar;65(3):259-61. DM2E5VZ RU https://pubmed.ncbi.nlm.nih.gov/11908961 DMCA76M DI DMCA76M DMCA76M DN Cyclotheonamide E5 DMCA76M MI TT6L509 DMCA76M MN Coagulation factor IIa (F2) DMCA76M MT DTT DMCA76M MA Inhibitor DMCA76M RN Cyclotheonamide E4 and E5, new potent tryptase inhibitors from an Ircinia species of sponge. J Nat Prod. 2002 Mar;65(3):259-61. DMCA76M RU https://pubmed.ncbi.nlm.nih.gov/11908961 DMTS8D5 DI DMTS8D5 DMTS8D5 DN CYLINDOL A DMTS8D5 MI TT2J34L DMTS8D5 MN Arachidonate 5-lipoxygenase (5-LOX) DMTS8D5 MT DTT DMTS8D5 MA Inhibitor DMTS8D5 RN Cylindol A, a novel biphenyl ether with 5-lipoxygenase inhibitory activity, and a related compound from Imperata Cylindrica. J Nat Prod. 1994 Sep;57(9):1290-3. DMTS8D5 RU https://pubmed.ncbi.nlm.nih.gov/7798964 DMCRU4H DI DMCRU4H DMCRU4H DN CYLINDROL A DMCRU4H MI TT7WZIJ DMCRU4H MN CAAX farnesyltransferase beta (FNTB) DMCRU4H MT DTT DMCRU4H MA Inhibitor DMCRU4H RN Ras farnesyltransferase: a new therapeutic target. J Med Chem. 1997 Sep 12;40(19):2971-90. DMCRU4H RU https://pubmed.ncbi.nlm.nih.gov/9301658 DMQWLIC DI DMQWLIC DMQWLIC DN Cylopentenyl cytosine DMQWLIC MI TTN12BZ DMQWLIC MN CTP synthase (CTPS1) DMQWLIC MT DTT DMQWLIC MA Inhibitor DMQWLIC RN Comments on: cylopentenyl cytosine inhibits cytidine triphosphate synthetase in paediatric acute non-lymphocytic leukaemia: a promising target for chemotherapy. A.C. Verschuur et al. Eur J Cancer 2000, 36, 627-635. Eur J Cancer. 2001 Jan;37(2):290. DMQWLIC RU https://pubmed.ncbi.nlm.nih.gov/11243234 DM5NFEA DI DM5NFEA DM5NFEA DN CYM2503 DM5NFEA MI TTOPAY7 DM5NFEA MN Galanin receptor (GAL-R) DM5NFEA MT DTT DM5NFEA MA Modulator (allosteric modulator) DM5NFEA RN GalR2-positive allosteric modulator exhibits anticonvulsant effects in animal models. Proc Natl Acad Sci U S A. 2010 Aug 24;107(34):15229-34. DM5NFEA RU https://pubmed.ncbi.nlm.nih.gov/20660766 DMGTZ9Q DI DMGTZ9Q DMGTZ9Q DN CYM5181 DMGTZ9Q MI TT9JZCK DMGTZ9Q MN Sphingosine-1-phosphate receptor 1 (S1PR1) DMGTZ9Q MT DTT DMGTZ9Q MA Agonist DMGTZ9Q RN Full pharmacological efficacy of a novel S1P1 agonist that does not require S1P-like headgroup interactions. Mol Pharmacol. 2008 Nov;74(5):1308-18. DMGTZ9Q RU https://pubmed.ncbi.nlm.nih.gov/18708635 DMURD2E DI DMURD2E DMURD2E DN CYM5442 DMURD2E MI TT9JZCK DMURD2E MN Sphingosine-1-phosphate receptor 1 (S1PR1) DMURD2E MT DTT DMURD2E MA Agonist DMURD2E RN Full pharmacological efficacy of a novel S1P1 agonist that does not require S1P-like headgroup interactions. Mol Pharmacol. 2008 Nov;74(5):1308-18. DMURD2E RU https://pubmed.ncbi.nlm.nih.gov/18708635 DMG0PHU DI DMG0PHU DMG0PHU DN CYNAROPICRIN DMG0PHU MI TTICX3S DMG0PHU MN Bacterial UDP-N-acetylglucosamine carboxyvinyltransferase (Bact murA) DMG0PHU MT DTT DMG0PHU MA Inhibitor DMG0PHU RN Sesquiterpene lactones are potent and irreversible inhibitors of the antibacterial target enzyme MurA. Bioorg Med Chem Lett. 2006 Nov 1;16(21):5605-9. DMG0PHU RU https://pubmed.ncbi.nlm.nih.gov/16945528 DMZCA15 DI DMZCA15 DMZCA15 DN Cynooxide anion DMZCA15 MI TTHQPL7 DMZCA15 MN Carbonic anhydrase I (CA-I) DMZCA15 MT DTT DMZCA15 MA Inhibitor DMZCA15 RN Carbonic anhydrase inhibitors. Inhibition of the beta-class enzyme from the methanoarchaeon Methanobacterium thermoautotrophicum (Cab) with anions. Bioorg Med Chem Lett. 2004 Sep 6;14(17):4563-7. DMZCA15 RU https://pubmed.ncbi.nlm.nih.gov/15357993 DMBTU7G DI DMBTU7G DMBTU7G DN Cypate-[(RGD)2-NH2]1 DMBTU7G MI TTT1R2L DMBTU7G MN Integrin alpha-V (ITGAV) DMBTU7G MT DTT DMBTU7G MA Inhibitor DMBTU7G RN Design, synthesis, and evaluation of near infrared fluorescent multimeric RGD peptides for targeting tumors. J Med Chem. 2006 Apr 6;49(7):2268-75. DMBTU7G RU https://pubmed.ncbi.nlm.nih.gov/16570923 DMBTU7G DI DMBTU7G DMBTU7G DN Cypate-[(RGD)2-NH2]1 DMBTU7G MI TTJA1ZO DMBTU7G MN ITGB3 messenger RNA (ITGB3 mRNA) DMBTU7G MT DTT DMBTU7G MA Inhibitor DMBTU7G RN Design, synthesis, and evaluation of near infrared fluorescent multimeric RGD peptides for targeting tumors. J Med Chem. 2006 Apr 6;49(7):2268-75. DMBTU7G RU https://pubmed.ncbi.nlm.nih.gov/16570923 DMJNW9P DI DMJNW9P DMJNW9P DN Cypate-[(RGD)2-NH2]2 DMJNW9P MI TTT1R2L DMJNW9P MN Integrin alpha-V (ITGAV) DMJNW9P MT DTT DMJNW9P MA Inhibitor DMJNW9P RN Design, synthesis, and evaluation of near infrared fluorescent multimeric RGD peptides for targeting tumors. J Med Chem. 2006 Apr 6;49(7):2268-75. DMJNW9P RU https://pubmed.ncbi.nlm.nih.gov/16570923 DMJNW9P DI DMJNW9P DMJNW9P DN Cypate-[(RGD)2-NH2]2 DMJNW9P MI TTJA1ZO DMJNW9P MN ITGB3 messenger RNA (ITGB3 mRNA) DMJNW9P MT DTT DMJNW9P MA Inhibitor DMJNW9P RN Design, synthesis, and evaluation of near infrared fluorescent multimeric RGD peptides for targeting tumors. J Med Chem. 2006 Apr 6;49(7):2268-75. DMJNW9P RU https://pubmed.ncbi.nlm.nih.gov/16570923 DMWINK5 DI DMWINK5 DMWINK5 DN Cypate-[(RGD)3-NH2]1 DMWINK5 MI TTT1R2L DMWINK5 MN Integrin alpha-V (ITGAV) DMWINK5 MT DTT DMWINK5 MA Inhibitor DMWINK5 RN Design, synthesis, and evaluation of near infrared fluorescent multimeric RGD peptides for targeting tumors. J Med Chem. 2006 Apr 6;49(7):2268-75. DMWINK5 RU https://pubmed.ncbi.nlm.nih.gov/16570923 DMWINK5 DI DMWINK5 DMWINK5 DN Cypate-[(RGD)3-NH2]1 DMWINK5 MI TTJA1ZO DMWINK5 MN ITGB3 messenger RNA (ITGB3 mRNA) DMWINK5 MT DTT DMWINK5 MA Inhibitor DMWINK5 RN Design, synthesis, and evaluation of near infrared fluorescent multimeric RGD peptides for targeting tumors. J Med Chem. 2006 Apr 6;49(7):2268-75. DMWINK5 RU https://pubmed.ncbi.nlm.nih.gov/16570923 DM1SAIX DI DM1SAIX DM1SAIX DN Cypate-[(RGD)3-NH2]2 DM1SAIX MI TTT1R2L DM1SAIX MN Integrin alpha-V (ITGAV) DM1SAIX MT DTT DM1SAIX MA Inhibitor DM1SAIX RN Design, synthesis, and evaluation of near infrared fluorescent multimeric RGD peptides for targeting tumors. J Med Chem. 2006 Apr 6;49(7):2268-75. DM1SAIX RU https://pubmed.ncbi.nlm.nih.gov/16570923 DM1SAIX DI DM1SAIX DM1SAIX DN Cypate-[(RGD)3-NH2]2 DM1SAIX MI TTJA1ZO DM1SAIX MN ITGB3 messenger RNA (ITGB3 mRNA) DM1SAIX MT DTT DM1SAIX MA Inhibitor DM1SAIX RN Design, synthesis, and evaluation of near infrared fluorescent multimeric RGD peptides for targeting tumors. J Med Chem. 2006 Apr 6;49(7):2268-75. DM1SAIX RU https://pubmed.ncbi.nlm.nih.gov/16570923 DM3GLMP DI DM3GLMP DM3GLMP DN Cypate-[(RGD)4-NH2]1 DM3GLMP MI TTT1R2L DM3GLMP MN Integrin alpha-V (ITGAV) DM3GLMP MT DTT DM3GLMP MA Inhibitor DM3GLMP RN Design, synthesis, and evaluation of near infrared fluorescent multimeric RGD peptides for targeting tumors. J Med Chem. 2006 Apr 6;49(7):2268-75. DM3GLMP RU https://pubmed.ncbi.nlm.nih.gov/16570923 DM3GLMP DI DM3GLMP DM3GLMP DN Cypate-[(RGD)4-NH2]1 DM3GLMP MI TTJA1ZO DM3GLMP MN ITGB3 messenger RNA (ITGB3 mRNA) DM3GLMP MT DTT DM3GLMP MA Inhibitor DM3GLMP RN Design, synthesis, and evaluation of near infrared fluorescent multimeric RGD peptides for targeting tumors. J Med Chem. 2006 Apr 6;49(7):2268-75. DM3GLMP RU https://pubmed.ncbi.nlm.nih.gov/16570923 DMR74OM DI DMR74OM DMR74OM DN Cypate-[(RGD)4-NH2]2 DMR74OM MI TTT1R2L DMR74OM MN Integrin alpha-V (ITGAV) DMR74OM MT DTT DMR74OM MA Inhibitor DMR74OM RN Design, synthesis, and evaluation of near infrared fluorescent multimeric RGD peptides for targeting tumors. J Med Chem. 2006 Apr 6;49(7):2268-75. DMR74OM RU https://pubmed.ncbi.nlm.nih.gov/16570923 DMR74OM DI DMR74OM DMR74OM DN Cypate-[(RGD)4-NH2]2 DMR74OM MI TTJA1ZO DMR74OM MN ITGB3 messenger RNA (ITGB3 mRNA) DMR74OM MT DTT DMR74OM MA Inhibitor DMR74OM RN Design, synthesis, and evaluation of near infrared fluorescent multimeric RGD peptides for targeting tumors. J Med Chem. 2006 Apr 6;49(7):2268-75. DMR74OM RU https://pubmed.ncbi.nlm.nih.gov/16570923 DM64L9I DI DM64L9I DM64L9I DN CyPPA DM64L9I MI TT2T5M0 DM64L9I MN Calcium-activated potassium channel KCa2.2 (KCNN2) DM64L9I MT DTT DM64L9I MA Activator DM64L9I RN Selective positive modulation of the SK3 and SK2 subtypes of small conductance Ca2+-activated K+ channels. Br J Pharmacol. 2007 Jul;151(5):655-65. DM64L9I RU https://pubmed.ncbi.nlm.nih.gov/17486140 DM64L9I DI DM64L9I DM64L9I DN CyPPA DM64L9I MI TT9JH25 DM64L9I MN Calcium-activated potassium channel KCa2.3 (KCNN3) DM64L9I MT DTT DM64L9I MA Activator DM64L9I RN Selective positive modulation of the SK3 and SK2 subtypes of small conductance Ca2+-activated K+ channels. Br J Pharmacol. 2007 Jul;151(5):655-65. DM64L9I RU https://pubmed.ncbi.nlm.nih.gov/17486140 DME9LPO DI DME9LPO DME9LPO DN cyPPTS DME9LPO MI TTXJ47W DME9LPO MN Metabotropic glutamate receptor 2 (mGluR2) DME9LPO MT DTT DME9LPO MA Modulator (allosteric modulator) DME9LPO RN Metabotropic glutamate 2 receptor potentiators: receptor modulation, frequency-dependent synaptic activity, and efficacy in preclinical anxiety and... Psychopharmacology (Berl). 2005 Apr;179(1):271-83. DME9LPO RU https://pubmed.ncbi.nlm.nih.gov/15717213 DMJXCVA DI DMJXCVA DMJXCVA DN CYPRODIME DMJXCVA MI TTKWM86 DMJXCVA MN Opioid receptor mu (MOP) DMJXCVA MT DTT DMJXCVA MA Inhibitor DMJXCVA RN Synthesis and biological evaluation of 14-alkoxymorphinans. 21. Novel 4-alkoxy and 14-phenylpropoxy derivatives of the mu opioid receptor antagonis... J Med Chem. 2004 Jun 3;47(12):3242-7. DMJXCVA RU https://pubmed.ncbi.nlm.nih.gov/15163203 DM7T96M DI DM7T96M DM7T96M DN Cyprodine DM7T96M MI TTN4QDT DM7T96M MN Opioid receptor (OPR) DM7T96M MT DTT DM7T96M MA Antagonist DM7T96M RN Novel pharmacological targets for the treatment of Parkinson's disease. Nat Rev Drug Discov. 2006 Oct;5(10):845-54. DM7T96M RU https://pubmed.ncbi.nlm.nih.gov/17016425 DMS5DHY DI DMS5DHY DMS5DHY DN Cystamine DMS5DHY MI TTNFESW DMS5DHY MN Glutamate--cysteine ligase modifier (GCLM) DMS5DHY MT DTT DMS5DHY MA Inhibitor DMS5DHY RN The gamma-glutamylcysteine synthetase of Onchocerca volvulus. Mol Biochem Parasitol. 2000 Dec;111(2):243-51. DMS5DHY RU https://pubmed.ncbi.nlm.nih.gov/11163433 DM4GZUJ DI DM4GZUJ DM4GZUJ DN Cysteine Sulfenic Acid DM4GZUJ MI TTJGY7A DM4GZUJ MN Complement C3 (CO3) DM4GZUJ MT DTT DM4GZUJ MA Inhibitor DM4GZUJ RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DM4GZUJ RU https://pubmed.ncbi.nlm.nih.gov/17139284 DM4GZUJ DI DM4GZUJ DM4GZUJ DN Cysteine Sulfenic Acid DM4GZUJ MI TTR0SWN DM4GZUJ MN M-phase inducer phosphatase 2 (MPIP2) DM4GZUJ MT DTT DM4GZUJ MA Inhibitor DM4GZUJ RN DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Nucleic Acids Res. 2011 Jan;39(Database issue):D1035-41. DM4GZUJ RU https://pubmed.ncbi.nlm.nih.gov/21059682 DM4GZUJ DI DM4GZUJ DM4GZUJ DN Cysteine Sulfenic Acid DM4GZUJ MI TT6PKBN DM4GZUJ MN Proto-oncogene c-Src (SRC) DM4GZUJ MT DTT DM4GZUJ MA Inhibitor DM4GZUJ RN DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Nucleic Acids Res. 2011 Jan;39(Database issue):D1035-41. DM4GZUJ RU https://pubmed.ncbi.nlm.nih.gov/21059682 DM4GZUJ DI DM4GZUJ DM4GZUJ DN Cysteine Sulfenic Acid DM4GZUJ MI TTELIN2 DM4GZUJ MN PTPN1 messenger RNA (PTPN1 mRNA) DM4GZUJ MT DTT DM4GZUJ MA Inhibitor DM4GZUJ RN DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Nucleic Acids Res. 2011 Jan;39(Database issue):D1035-41. DM4GZUJ RU https://pubmed.ncbi.nlm.nih.gov/21059682 DMXI8FP DI DMXI8FP DMXI8FP DN Cysteinesulfonic Acid DMXI8FP MI TT36ETB DMXI8FP MN Cathepsin L (CTSL) DMXI8FP MT DTT DMXI8FP MA Inhibitor DMXI8FP RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMXI8FP RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMXI8FP DI DMXI8FP DMXI8FP DN Cysteinesulfonic Acid DMXI8FP MI TTR0SWN DMXI8FP MN M-phase inducer phosphatase 2 (MPIP2) DMXI8FP MT DTT DMXI8FP MA Inhibitor DMXI8FP RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMXI8FP RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMXI8FP DI DMXI8FP DMXI8FP DN Cysteinesulfonic Acid DMXI8FP MI TTELIN2 DMXI8FP MN PTPN1 messenger RNA (PTPN1 mRNA) DMXI8FP MT DTT DMXI8FP MA Inhibitor DMXI8FP RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMXI8FP RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMXI8FP DI DMXI8FP DMXI8FP DN Cysteinesulfonic Acid DMXI8FP MI TTICO5G DMXI8FP MN Staphylococcus Peptide deformylase (Stap-coc def) DMXI8FP MT DTT DMXI8FP MA Inhibitor DMXI8FP RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMXI8FP RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMK0W8E DI DMK0W8E DMK0W8E DN Cytidine DMK0W8E MI DENV24I DMK0W8E MN Nicotinamide riboside kinase 1 (NRK1) DMK0W8E MT DME DMK0W8E MA Metabolism DMK0W8E RN Nicotinamide riboside kinase structures reveal new pathways to NAD+. PLoS Biol. 2007 Oct 2;5(10):e263. DMK0W8E RU https://www.ncbi.nlm.nih.gov/pubmed/?term=17914902 DMK0W8E DI DMK0W8E DMK0W8E DN Cytidine DMK0W8E MI DE8DJ3N DMK0W8E MN Nicotinamide riboside kinase 2 (NRK2) DMK0W8E MT DME DMK0W8E MA Metabolism DMK0W8E RN Nicotinamide riboside kinase structures reveal new pathways to NAD+. PLoS Biol. 2007 Oct 2;5(10):e263. DMK0W8E RU https://www.ncbi.nlm.nih.gov/pubmed/?term=17914902 DMK0W8E DI DMK0W8E DMK0W8E DN Cytidine DMK0W8E MI DE478BP DMK0W8E MN Uridine-cytidine kinase 1 (UCK1) DMK0W8E MT DME DMK0W8E MA Metabolism DMK0W8E RN Phosphorylation of uridine and cytidine nucleoside analogs by two human uridine-cytidine kinases. Mol Pharmacol. 2001 May;59(5):1181-6. DMK0W8E RU https://www.ncbi.nlm.nih.gov/pubmed/?term=11306702 DMK0W8E DI DMK0W8E DMK0W8E DN Cytidine DMK0W8E MI DETN1O0 DMK0W8E MN Uridine-cytidine kinase 2 (UCK2) DMK0W8E MT DME DMK0W8E MA Metabolism DMK0W8E RN Phosphorylation of uridine and cytidine nucleoside analogs by two human uridine-cytidine kinases. Mol Pharmacol. 2001 May;59(5):1181-6. DMK0W8E RU https://www.ncbi.nlm.nih.gov/pubmed/?term=11306702 DMA5FGS DI DMA5FGS DMA5FGS DN Cytidine-5'-Diphosphate DMA5FGS MI TTQ8J1V DMA5FGS MN Bacterial Deoxy-manno-octulosonate cytidylyltransferase (Bact kdsB) DMA5FGS MT DTT DMA5FGS MA Inhibitor DMA5FGS RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMA5FGS RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMA5FGS DI DMA5FGS DMA5FGS DN Cytidine-5'-Diphosphate DMA5FGS MI TTMFYEC DMA5FGS MN Streptococcus Cytidylate kinase (Stre-coc cmk) DMA5FGS MT DTT DMA5FGS MA Inhibitor DMA5FGS RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMA5FGS RU https://pubmed.ncbi.nlm.nih.gov/17139284 DM6PAXD DI DM6PAXD DM6PAXD DN Cytidine-5'-Monophosphate DM6PAXD MI TTQ8J1V DM6PAXD MN Bacterial Deoxy-manno-octulosonate cytidylyltransferase (Bact kdsB) DM6PAXD MT DTT DM6PAXD MA Inhibitor DM6PAXD RN DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Nucleic Acids Res. 2011 Jan;39(Database issue):D1035-41. DM6PAXD RU https://pubmed.ncbi.nlm.nih.gov/21059682 DM6PAXD DI DM6PAXD DM6PAXD DN Cytidine-5'-Monophosphate DM6PAXD MI TTMFYEC DM6PAXD MN Streptococcus Cytidylate kinase (Stre-coc cmk) DM6PAXD MT DTT DM6PAXD MA Inhibitor DM6PAXD RN DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Nucleic Acids Res. 2011 Jan;39(Database issue):D1035-41. DM6PAXD RU https://pubmed.ncbi.nlm.nih.gov/21059682 DMPT4WM DI DMPT4WM DMPT4WM DN Cytosine Arabinose-5'-Phosphate DMPT4WM MI TTMFYEC DMPT4WM MN Streptococcus Cytidylate kinase (Stre-coc cmk) DMPT4WM MT DTT DMPT4WM MA Inhibitor DMPT4WM RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMPT4WM RU https://pubmed.ncbi.nlm.nih.gov/17139284 DM7SVLZ DI DM7SVLZ DM7SVLZ DN Cytotoxin Peptide Conjugate DM7SVLZ MI TTIND6G DM7SVLZ MN Somatostatin receptor type 1 (SSTR1) DM7SVLZ MT DTT DM7SVLZ MA Inhibitor DM7SVLZ RN An adjustable release rate linking strategy for cytotoxin-peptide conjugates. Bioorg Med Chem Lett. 2003 Mar 10;13(5):799-803. DM7SVLZ RU https://pubmed.ncbi.nlm.nih.gov/12617894 DM7SVLZ DI DM7SVLZ DM7SVLZ DN Cytotoxin Peptide Conjugate DM7SVLZ MI TTZ6T9E DM7SVLZ MN Somatostatin receptor type 2 (SSTR2) DM7SVLZ MT DTT DM7SVLZ MA Inhibitor DM7SVLZ RN An adjustable release rate linking strategy for cytotoxin-peptide conjugates. Bioorg Med Chem Lett. 2003 Mar 10;13(5):799-803. DM7SVLZ RU https://pubmed.ncbi.nlm.nih.gov/12617894 DM7SVLZ DI DM7SVLZ DM7SVLZ DN Cytotoxin Peptide Conjugate DM7SVLZ MI TTJX3UE DM7SVLZ MN Somatostatin receptor type 3 (SSTR3) DM7SVLZ MT DTT DM7SVLZ MA Inhibitor DM7SVLZ RN An adjustable release rate linking strategy for cytotoxin-peptide conjugates. Bioorg Med Chem Lett. 2003 Mar 10;13(5):799-803. DM7SVLZ RU https://pubmed.ncbi.nlm.nih.gov/12617894 DM7SVLZ DI DM7SVLZ DM7SVLZ DN Cytotoxin Peptide Conjugate DM7SVLZ MI TTAE1BR DM7SVLZ MN Somatostatin receptor type 4 (SSTR4) DM7SVLZ MT DTT DM7SVLZ MA Inhibitor DM7SVLZ RN An adjustable release rate linking strategy for cytotoxin-peptide conjugates. Bioorg Med Chem Lett. 2003 Mar 10;13(5):799-803. DM7SVLZ RU https://pubmed.ncbi.nlm.nih.gov/12617894 DM7SVLZ DI DM7SVLZ DM7SVLZ DN Cytotoxin Peptide Conjugate DM7SVLZ MI TT2BC4G DM7SVLZ MN Somatostatin receptor type 5 (SSTR5) DM7SVLZ MT DTT DM7SVLZ MA Inhibitor DM7SVLZ RN An adjustable release rate linking strategy for cytotoxin-peptide conjugates. Bioorg Med Chem Lett. 2003 Mar 10;13(5):799-803. DM7SVLZ RU https://pubmed.ncbi.nlm.nih.gov/12617894 DMLBYFG DI DMLBYFG DMLBYFG DN CZC 24832 DMLBYFG MI TTHBTOP DMLBYFG MN PI3-kinase gamma (PIK3CG) DMLBYFG MT DTT DMLBYFG MA Inhibitor DMLBYFG RN A selective inhibitor reveals PI3Kgamma dependence of T(H)17 cell differentiation. Nat Chem Biol. 2012 Apr 29;8(6):576-82. DMLBYFG RU https://pubmed.ncbi.nlm.nih.gov/22544264 DMYBL5G DI DMYBL5G DMYBL5G DN CZC-19091 DMYBL5G MI TTHBTOP DMYBL5G MN PI3-kinase gamma (PIK3CG) DMYBL5G MT DTT DMYBL5G MA Inhibitor DMYBL5G RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2156). DMYBL5G RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2156 DM1E5C4 DI DM1E5C4 DM1E5C4 DN D 2343 DM1E5C4 MI TT2CJVK DM1E5C4 MN Adrenergic receptor beta-2 (ADRB2) DM1E5C4 MT DTT DM1E5C4 MA Agonist DM1E5C4 RN A new beta 2-adrenoceptor agonist--D 2343--with long duration. Inhalation comparison with terbutaline in asthmatics. Allergy. 1984 Aug;39(6):485-9. DM1E5C4 RU https://pubmed.ncbi.nlm.nih.gov/6437263 DMAX7LW DI DMAX7LW DMAX7LW DN d(CH2)5[D-Ile2,Ile4]AVP DMAX7LW MI TTK8R02 DMAX7LW MN Vasopressin V2 receptor (V2R) DMAX7LW MT DTT DMAX7LW MA Antagonist DMAX7LW RN Binding properties of a selective tritiated vasopressin V2 receptor antagonist, [H]-SR 121463. Kidney Int. 2000 Oct;58(4):1613-22. DMAX7LW RU https://pubmed.ncbi.nlm.nih.gov/11012895 DMVHMGA DI DMVHMGA DMVHMGA DN D(CH2)5[Tyr(Me)2,Thr4,Orn8(5/6C-Flu),Tyr-NH29]VT DMVHMGA MI TTSCIUP DMVHMGA MN Oxytocin receptor (OTR) DMVHMGA MT DTT DMVHMGA MA Inhibitor DMVHMGA RN Synthesis and characterization of fluorescent antagonists and agonists for human oxytocin and vasopressin V(1)(a) receptors. J Med Chem. 2002 Jun 6;45(12):2579-88. DMVHMGA RU https://pubmed.ncbi.nlm.nih.gov/12036367 DMVHMGA DI DMVHMGA DMVHMGA DN D(CH2)5[Tyr(Me)2,Thr4,Orn8(5/6C-Flu),Tyr-NH29]VT DMVHMGA MI TT4TFGN DMVHMGA MN Vasopressin V1a receptor (V1AR) DMVHMGA MT DTT DMVHMGA MA Inhibitor DMVHMGA RN Synthesis and characterization of fluorescent antagonists and agonists for human oxytocin and vasopressin V(1)(a) receptors. J Med Chem. 2002 Jun 6;45(12):2579-88. DMVHMGA RU https://pubmed.ncbi.nlm.nih.gov/12036367 DM1BMT7 DI DM1BMT7 DM1BMT7 DN D(CH2)5[Tyr(Me)2,Thr4,Orn8,Tyr9-NH2]VT DM1BMT7 MI TTSCIUP DM1BMT7 MN Oxytocin receptor (OTR) DM1BMT7 MT DTT DM1BMT7 MA Inhibitor DM1BMT7 RN Synthesis and characterization of fluorescent antagonists and agonists for human oxytocin and vasopressin V(1)(a) receptors. J Med Chem. 2002 Jun 6;45(12):2579-88. DM1BMT7 RU https://pubmed.ncbi.nlm.nih.gov/12036367 DM1BMT7 DI DM1BMT7 DM1BMT7 DN D(CH2)5[Tyr(Me)2,Thr4,Orn8,Tyr9-NH2]VT DM1BMT7 MI TT4TFGN DM1BMT7 MN Vasopressin V1a receptor (V1AR) DM1BMT7 MT DTT DM1BMT7 MA Inhibitor DM1BMT7 RN Synthesis and characterization of fluorescent antagonists and agonists for human oxytocin and vasopressin V(1)(a) receptors. J Med Chem. 2002 Jun 6;45(12):2579-88. DM1BMT7 RU https://pubmed.ncbi.nlm.nih.gov/12036367 DM1BMT7 DI DM1BMT7 DM1BMT7 DN D(CH2)5[Tyr(Me)2,Thr4,Orn8,Tyr9-NH2]VT DM1BMT7 MI TTK8R02 DM1BMT7 MN Vasopressin V2 receptor (V2R) DM1BMT7 MT DTT DM1BMT7 MA Inhibitor DM1BMT7 RN Synthesis and characterization of fluorescent antagonists and agonists for human oxytocin and vasopressin V(1)(a) receptors. J Med Chem. 2002 Jun 6;45(12):2579-88. DM1BMT7 RU https://pubmed.ncbi.nlm.nih.gov/12036367 DMHTSAX DI DMHTSAX DMHTSAX DN d(CH2)5[Tyr(Me)2]AVP DMHTSAX MI TTSCIUP DMHTSAX MN Oxytocin receptor (OTR) DMHTSAX MT DTT DMHTSAX MA Antagonist DMHTSAX RN Characterization of the human oxytocin receptor stably expressed in 293 human embryonic kidney cells. Life Sci. 1995;57(24):2253-61. DMHTSAX RU https://pubmed.ncbi.nlm.nih.gov/7475979 DMHTSAX DI DMHTSAX DMHTSAX DN d(CH2)5[Tyr(Me)2]AVP DMHTSAX MI TT4TFGN DMHTSAX MN Vasopressin V1a receptor (V1AR) DMHTSAX MT DTT DMHTSAX MA Antagonist DMHTSAX RN Conserved aromatic residues in the transmembrane region VI of the V1a vasopressin receptor differentiate agonist vs. antagonist ligand binding. Eur J Biochem. 2000 Jul;267(13):4253-63. DMHTSAX RU https://pubmed.ncbi.nlm.nih.gov/10866830 DMHTSAX DI DMHTSAX DMHTSAX DN d(CH2)5[Tyr(Me)2]AVP DMHTSAX MI TTL9MHW DMHTSAX MN Vasopressin V1b receptor (V1BR) DMHTSAX MT DTT DMHTSAX MA Antagonist DMHTSAX RN 1-desamino-8-D-arginine vasopressin (DDAVP) as an agonist on V1b vasopressin receptor. Biochem Pharmacol. 1997 Jun 1;53(11):1711-7. DMHTSAX RU https://pubmed.ncbi.nlm.nih.gov/9264324 DMHTSAX DI DMHTSAX DMHTSAX DN d(CH2)5[Tyr(Me)2]AVP DMHTSAX MI TTK8R02 DMHTSAX MN Vasopressin V2 receptor (V2R) DMHTSAX MT DTT DMHTSAX MA Antagonist DMHTSAX RN Binding properties of a selective tritiated vasopressin V2 receptor antagonist, [H]-SR 121463. Kidney Int. 2000 Oct;58(4):1613-22. DMHTSAX RU https://pubmed.ncbi.nlm.nih.gov/11012895 DMCU8HK DI DMCU8HK DMCU8HK DN D[Arg4,Dab8]VP DMCU8HK MI TTSCIUP DMCU8HK MN Oxytocin receptor (OTR) DMCU8HK MT DTT DMCU8HK MA Inhibitor DMCU8HK RN Design and synthesis of the first selective agonists for the rat vasopressin V(1b) receptor: based on modifications of deamino-[Cys1]arginine vasop... J Med Chem. 2007 Feb 22;50(4):835-47. DMCU8HK RU https://pubmed.ncbi.nlm.nih.gov/17300166 DMCU8HK DI DMCU8HK DMCU8HK DN D[Arg4,Dab8]VP DMCU8HK MI TT4TFGN DMCU8HK MN Vasopressin V1a receptor (V1AR) DMCU8HK MT DTT DMCU8HK MA Inhibitor DMCU8HK RN Design and synthesis of the first selective agonists for the rat vasopressin V(1b) receptor: based on modifications of deamino-[Cys1]arginine vasop... J Med Chem. 2007 Feb 22;50(4):835-47. DMCU8HK RU https://pubmed.ncbi.nlm.nih.gov/17300166 DMCU8HK DI DMCU8HK DMCU8HK DN D[Arg4,Dab8]VP DMCU8HK MI TTL9MHW DMCU8HK MN Vasopressin V1b receptor (V1BR) DMCU8HK MT DTT DMCU8HK MA Inhibitor DMCU8HK RN Design and synthesis of the first selective agonists for the rat vasopressin V(1b) receptor: based on modifications of deamino-[Cys1]arginine vasop... J Med Chem. 2007 Feb 22;50(4):835-47. DMCU8HK RU https://pubmed.ncbi.nlm.nih.gov/17300166 DMCU8HK DI DMCU8HK DMCU8HK DN D[Arg4,Dab8]VP DMCU8HK MI TTK8R02 DMCU8HK MN Vasopressin V2 receptor (V2R) DMCU8HK MT DTT DMCU8HK MA Inhibitor DMCU8HK RN Design and synthesis of the first selective agonists for the rat vasopressin V(1b) receptor: based on modifications of deamino-[Cys1]arginine vasop... J Med Chem. 2007 Feb 22;50(4):835-47. DMCU8HK RU https://pubmed.ncbi.nlm.nih.gov/17300166 DM69OVM DI DM69OVM DM69OVM DN D[Arg4,Lys8]VP DM69OVM MI TTSCIUP DM69OVM MN Oxytocin receptor (OTR) DM69OVM MT DTT DM69OVM MA Inhibitor DM69OVM RN Design and synthesis of the first selective agonists for the rat vasopressin V(1b) receptor: based on modifications of deamino-[Cys1]arginine vasop... J Med Chem. 2007 Feb 22;50(4):835-47. DM69OVM RU https://pubmed.ncbi.nlm.nih.gov/17300166 DM69OVM DI DM69OVM DM69OVM DN D[Arg4,Lys8]VP DM69OVM MI TT4TFGN DM69OVM MN Vasopressin V1a receptor (V1AR) DM69OVM MT DTT DM69OVM MA Inhibitor DM69OVM RN Design and synthesis of the first selective agonists for the rat vasopressin V(1b) receptor: based on modifications of deamino-[Cys1]arginine vasop... J Med Chem. 2007 Feb 22;50(4):835-47. DM69OVM RU https://pubmed.ncbi.nlm.nih.gov/17300166 DM69OVM DI DM69OVM DM69OVM DN D[Arg4,Lys8]VP DM69OVM MI TTL9MHW DM69OVM MN Vasopressin V1b receptor (V1BR) DM69OVM MT DTT DM69OVM MA Inhibitor DM69OVM RN Design and synthesis of the first selective agonists for the rat vasopressin V(1b) receptor: based on modifications of deamino-[Cys1]arginine vasop... J Med Chem. 2007 Feb 22;50(4):835-47. DM69OVM RU https://pubmed.ncbi.nlm.nih.gov/17300166 DM69OVM DI DM69OVM DM69OVM DN D[Arg4,Lys8]VP DM69OVM MI TTK8R02 DM69OVM MN Vasopressin V2 receptor (V2R) DM69OVM MT DTT DM69OVM MA Inhibitor DM69OVM RN Design and synthesis of the first selective agonists for the rat vasopressin V(1b) receptor: based on modifications of deamino-[Cys1]arginine vasop... J Med Chem. 2007 Feb 22;50(4):835-47. DM69OVM RU https://pubmed.ncbi.nlm.nih.gov/17300166 DM8D4QT DI DM8D4QT DM8D4QT DN D[Arg4,Orn8]VP DM8D4QT MI TTSCIUP DM8D4QT MN Oxytocin receptor (OTR) DM8D4QT MT DTT DM8D4QT MA Inhibitor DM8D4QT RN Design and synthesis of the first selective agonists for the rat vasopressin V(1b) receptor: based on modifications of deamino-[Cys1]arginine vasop... J Med Chem. 2007 Feb 22;50(4):835-47. DM8D4QT RU https://pubmed.ncbi.nlm.nih.gov/17300166 DM8D4QT DI DM8D4QT DM8D4QT DN D[Arg4,Orn8]VP DM8D4QT MI TT4TFGN DM8D4QT MN Vasopressin V1a receptor (V1AR) DM8D4QT MT DTT DM8D4QT MA Inhibitor DM8D4QT RN Design and synthesis of the first selective agonists for the rat vasopressin V(1b) receptor: based on modifications of deamino-[Cys1]arginine vasop... J Med Chem. 2007 Feb 22;50(4):835-47. DM8D4QT RU https://pubmed.ncbi.nlm.nih.gov/17300166 DM8D4QT DI DM8D4QT DM8D4QT DN D[Arg4,Orn8]VP DM8D4QT MI TTL9MHW DM8D4QT MN Vasopressin V1b receptor (V1BR) DM8D4QT MT DTT DM8D4QT MA Inhibitor DM8D4QT RN Design and synthesis of the first selective agonists for the rat vasopressin V(1b) receptor: based on modifications of deamino-[Cys1]arginine vasop... J Med Chem. 2007 Feb 22;50(4):835-47. DM8D4QT RU https://pubmed.ncbi.nlm.nih.gov/17300166 DM8D4QT DI DM8D4QT DM8D4QT DN D[Arg4,Orn8]VP DM8D4QT MI TTK8R02 DM8D4QT MN Vasopressin V2 receptor (V2R) DM8D4QT MT DTT DM8D4QT MA Inhibitor DM8D4QT RN Design and synthesis of the first selective agonists for the rat vasopressin V(1b) receptor: based on modifications of deamino-[Cys1]arginine vasop... J Med Chem. 2007 Feb 22;50(4):835-47. DM8D4QT RU https://pubmed.ncbi.nlm.nih.gov/17300166 DM76Q2B DI DM76Q2B DM76Q2B DN D[Arg4]AVP DM76Q2B MI TTSCIUP DM76Q2B MN Oxytocin receptor (OTR) DM76Q2B MT DTT DM76Q2B MA Inhibitor DM76Q2B RN Design and synthesis of the first selective agonists for the rat vasopressin V(1b) receptor: based on modifications of deamino-[Cys1]arginine vasop... J Med Chem. 2007 Feb 22;50(4):835-47. DM76Q2B RU https://pubmed.ncbi.nlm.nih.gov/17300166 DM76Q2B DI DM76Q2B DM76Q2B DN D[Arg4]AVP DM76Q2B MI TT4TFGN DM76Q2B MN Vasopressin V1a receptor (V1AR) DM76Q2B MT DTT DM76Q2B MA Inhibitor DM76Q2B RN Design and synthesis of the first selective agonists for the rat vasopressin V(1b) receptor: based on modifications of deamino-[Cys1]arginine vasop... J Med Chem. 2007 Feb 22;50(4):835-47. DM76Q2B RU https://pubmed.ncbi.nlm.nih.gov/17300166 DM76Q2B DI DM76Q2B DM76Q2B DN D[Arg4]AVP DM76Q2B MI TTL9MHW DM76Q2B MN Vasopressin V1b receptor (V1BR) DM76Q2B MT DTT DM76Q2B MA Inhibitor DM76Q2B RN Design and synthesis of the first selective agonists for the rat vasopressin V(1b) receptor: based on modifications of deamino-[Cys1]arginine vasop... J Med Chem. 2007 Feb 22;50(4):835-47. DM76Q2B RU https://pubmed.ncbi.nlm.nih.gov/17300166 DM76Q2B DI DM76Q2B DM76Q2B DN D[Arg4]AVP DM76Q2B MI TTK8R02 DM76Q2B MN Vasopressin V2 receptor (V2R) DM76Q2B MT DTT DM76Q2B MA Inhibitor DM76Q2B RN Design and synthesis of the first selective agonists for the rat vasopressin V(1b) receptor: based on modifications of deamino-[Cys1]arginine vasop... J Med Chem. 2007 Feb 22;50(4):835-47. DM76Q2B RU https://pubmed.ncbi.nlm.nih.gov/17300166 DMCLUXI DI DMCLUXI DMCLUXI DN D[Cha4,Dab8]VP DMCLUXI MI TTSCIUP DMCLUXI MN Oxytocin receptor (OTR) DMCLUXI MT DTT DMCLUXI MA Inhibitor DMCLUXI RN Design and synthesis of the first selective agonists for the rat vasopressin V(1b) receptor: based on modifications of deamino-[Cys1]arginine vasop... J Med Chem. 2007 Feb 22;50(4):835-47. DMCLUXI RU https://pubmed.ncbi.nlm.nih.gov/17300166 DMCLUXI DI DMCLUXI DMCLUXI DN D[Cha4,Dab8]VP DMCLUXI MI TT4TFGN DMCLUXI MN Vasopressin V1a receptor (V1AR) DMCLUXI MT DTT DMCLUXI MA Inhibitor DMCLUXI RN Design and synthesis of the first selective agonists for the rat vasopressin V(1b) receptor: based on modifications of deamino-[Cys1]arginine vasop... J Med Chem. 2007 Feb 22;50(4):835-47. DMCLUXI RU https://pubmed.ncbi.nlm.nih.gov/17300166 DMCLUXI DI DMCLUXI DMCLUXI DN D[Cha4,Dab8]VP DMCLUXI MI TTL9MHW DMCLUXI MN Vasopressin V1b receptor (V1BR) DMCLUXI MT DTT DMCLUXI MA Inhibitor DMCLUXI RN Design and synthesis of the first selective agonists for the rat vasopressin V(1b) receptor: based on modifications of deamino-[Cys1]arginine vasop... J Med Chem. 2007 Feb 22;50(4):835-47. DMCLUXI RU https://pubmed.ncbi.nlm.nih.gov/17300166 DMCLUXI DI DMCLUXI DMCLUXI DN D[Cha4,Dab8]VP DMCLUXI MI TTK8R02 DMCLUXI MN Vasopressin V2 receptor (V2R) DMCLUXI MT DTT DMCLUXI MA Inhibitor DMCLUXI RN Design and synthesis of the first selective agonists for the rat vasopressin V(1b) receptor: based on modifications of deamino-[Cys1]arginine vasop... J Med Chem. 2007 Feb 22;50(4):835-47. DMCLUXI RU https://pubmed.ncbi.nlm.nih.gov/17300166 DMAPZKB DI DMAPZKB DMAPZKB DN D[Cha4,Dap8]VP DMAPZKB MI TTSCIUP DMAPZKB MN Oxytocin receptor (OTR) DMAPZKB MT DTT DMAPZKB MA Inhibitor DMAPZKB RN Design and synthesis of the first selective agonists for the rat vasopressin V(1b) receptor: based on modifications of deamino-[Cys1]arginine vasop... J Med Chem. 2007 Feb 22;50(4):835-47. DMAPZKB RU https://pubmed.ncbi.nlm.nih.gov/17300166 DMAPZKB DI DMAPZKB DMAPZKB DN D[Cha4,Dap8]VP DMAPZKB MI TT4TFGN DMAPZKB MN Vasopressin V1a receptor (V1AR) DMAPZKB MT DTT DMAPZKB MA Inhibitor DMAPZKB RN Design and synthesis of the first selective agonists for the rat vasopressin V(1b) receptor: based on modifications of deamino-[Cys1]arginine vasop... J Med Chem. 2007 Feb 22;50(4):835-47. DMAPZKB RU https://pubmed.ncbi.nlm.nih.gov/17300166 DMAPZKB DI DMAPZKB DMAPZKB DN D[Cha4,Dap8]VP DMAPZKB MI TTL9MHW DMAPZKB MN Vasopressin V1b receptor (V1BR) DMAPZKB MT DTT DMAPZKB MA Inhibitor DMAPZKB RN Design and synthesis of the first selective agonists for the rat vasopressin V(1b) receptor: based on modifications of deamino-[Cys1]arginine vasop... J Med Chem. 2007 Feb 22;50(4):835-47. DMAPZKB RU https://pubmed.ncbi.nlm.nih.gov/17300166 DMAPZKB DI DMAPZKB DMAPZKB DN D[Cha4,Dap8]VP DMAPZKB MI TTK8R02 DMAPZKB MN Vasopressin V2 receptor (V2R) DMAPZKB MT DTT DMAPZKB MA Inhibitor DMAPZKB RN Design and synthesis of the first selective agonists for the rat vasopressin V(1b) receptor: based on modifications of deamino-[Cys1]arginine vasop... J Med Chem. 2007 Feb 22;50(4):835-47. DMAPZKB RU https://pubmed.ncbi.nlm.nih.gov/17300166 DM0GO7U DI DM0GO7U DM0GO7U DN D[Cha4,Lys8]VP DM0GO7U MI TTSCIUP DM0GO7U MN Oxytocin receptor (OTR) DM0GO7U MT DTT DM0GO7U MA Inhibitor DM0GO7U RN Design and synthesis of the first selective agonists for the rat vasopressin V(1b) receptor: based on modifications of deamino-[Cys1]arginine vasop... J Med Chem. 2007 Feb 22;50(4):835-47. DM0GO7U RU https://pubmed.ncbi.nlm.nih.gov/17300166 DM0GO7U DI DM0GO7U DM0GO7U DN D[Cha4,Lys8]VP DM0GO7U MI TT4TFGN DM0GO7U MN Vasopressin V1a receptor (V1AR) DM0GO7U MT DTT DM0GO7U MA Inhibitor DM0GO7U RN Design and synthesis of the first selective agonists for the rat vasopressin V(1b) receptor: based on modifications of deamino-[Cys1]arginine vasop... J Med Chem. 2007 Feb 22;50(4):835-47. DM0GO7U RU https://pubmed.ncbi.nlm.nih.gov/17300166 DM0GO7U DI DM0GO7U DM0GO7U DN D[Cha4,Lys8]VP DM0GO7U MI TTL9MHW DM0GO7U MN Vasopressin V1b receptor (V1BR) DM0GO7U MT DTT DM0GO7U MA Inhibitor DM0GO7U RN Design and synthesis of the first selective agonists for the rat vasopressin V(1b) receptor: based on modifications of deamino-[Cys1]arginine vasop... J Med Chem. 2007 Feb 22;50(4):835-47. DM0GO7U RU https://pubmed.ncbi.nlm.nih.gov/17300166 DM0GO7U DI DM0GO7U DM0GO7U DN D[Cha4,Lys8]VP DM0GO7U MI TTK8R02 DM0GO7U MN Vasopressin V2 receptor (V2R) DM0GO7U MT DTT DM0GO7U MA Inhibitor DM0GO7U RN Design and synthesis of the first selective agonists for the rat vasopressin V(1b) receptor: based on modifications of deamino-[Cys1]arginine vasop... J Med Chem. 2007 Feb 22;50(4):835-47. DM0GO7U RU https://pubmed.ncbi.nlm.nih.gov/17300166 DMZWTJK DI DMZWTJK DMZWTJK DN D[Cha4,Orn8]VP DMZWTJK MI TTSCIUP DMZWTJK MN Oxytocin receptor (OTR) DMZWTJK MT DTT DMZWTJK MA Inhibitor DMZWTJK RN Design and synthesis of the first selective agonists for the rat vasopressin V(1b) receptor: based on modifications of deamino-[Cys1]arginine vasop... J Med Chem. 2007 Feb 22;50(4):835-47. DMZWTJK RU https://pubmed.ncbi.nlm.nih.gov/17300166 DMZWTJK DI DMZWTJK DMZWTJK DN D[Cha4,Orn8]VP DMZWTJK MI TT4TFGN DMZWTJK MN Vasopressin V1a receptor (V1AR) DMZWTJK MT DTT DMZWTJK MA Inhibitor DMZWTJK RN Design and synthesis of the first selective agonists for the rat vasopressin V(1b) receptor: based on modifications of deamino-[Cys1]arginine vasop... J Med Chem. 2007 Feb 22;50(4):835-47. DMZWTJK RU https://pubmed.ncbi.nlm.nih.gov/17300166 DMZWTJK DI DMZWTJK DMZWTJK DN D[Cha4,Orn8]VP DMZWTJK MI TTL9MHW DMZWTJK MN Vasopressin V1b receptor (V1BR) DMZWTJK MT DTT DMZWTJK MA Inhibitor DMZWTJK RN Design and synthesis of the first selective agonists for the rat vasopressin V(1b) receptor: based on modifications of deamino-[Cys1]arginine vasop... J Med Chem. 2007 Feb 22;50(4):835-47. DMZWTJK RU https://pubmed.ncbi.nlm.nih.gov/17300166 DMZWTJK DI DMZWTJK DMZWTJK DN D[Cha4,Orn8]VP DMZWTJK MI TTK8R02 DMZWTJK MN Vasopressin V2 receptor (V2R) DMZWTJK MT DTT DMZWTJK MA Inhibitor DMZWTJK RN Design and synthesis of the first selective agonists for the rat vasopressin V(1b) receptor: based on modifications of deamino-[Cys1]arginine vasop... J Med Chem. 2007 Feb 22;50(4):835-47. DMZWTJK RU https://pubmed.ncbi.nlm.nih.gov/17300166 DM8FCX5 DI DM8FCX5 DM8FCX5 DN D[Cha4]AVP DM8FCX5 MI TTSCIUP DM8FCX5 MN Oxytocin receptor (OTR) DM8FCX5 MT DTT DM8FCX5 MA Inhibitor DM8FCX5 RN Design and synthesis of the first selective agonists for the rat vasopressin V(1b) receptor: based on modifications of deamino-[Cys1]arginine vasop... J Med Chem. 2007 Feb 22;50(4):835-47. DM8FCX5 RU https://pubmed.ncbi.nlm.nih.gov/17300166 DM8FCX5 DI DM8FCX5 DM8FCX5 DN D[Cha4]AVP DM8FCX5 MI TT4TFGN DM8FCX5 MN Vasopressin V1a receptor (V1AR) DM8FCX5 MT DTT DM8FCX5 MA Inhibitor DM8FCX5 RN Design and synthesis of the first selective agonists for the rat vasopressin V(1b) receptor: based on modifications of deamino-[Cys1]arginine vasop... J Med Chem. 2007 Feb 22;50(4):835-47. DM8FCX5 RU https://pubmed.ncbi.nlm.nih.gov/17300166 DM8FCX5 DI DM8FCX5 DM8FCX5 DN D[Cha4]AVP DM8FCX5 MI TTL9MHW DM8FCX5 MN Vasopressin V1b receptor (V1BR) DM8FCX5 MT DTT DM8FCX5 MA Inhibitor DM8FCX5 RN Design and synthesis of the first selective agonists for the rat vasopressin V(1b) receptor: based on modifications of deamino-[Cys1]arginine vasop... J Med Chem. 2007 Feb 22;50(4):835-47. DM8FCX5 RU https://pubmed.ncbi.nlm.nih.gov/17300166 DM8FCX5 DI DM8FCX5 DM8FCX5 DN D[Cha4]AVP DM8FCX5 MI TTK8R02 DM8FCX5 MN Vasopressin V2 receptor (V2R) DM8FCX5 MT DTT DM8FCX5 MA Inhibitor DM8FCX5 RN Design and synthesis of the first selective agonists for the rat vasopressin V(1b) receptor: based on modifications of deamino-[Cys1]arginine vasop... J Med Chem. 2007 Feb 22;50(4):835-47. DM8FCX5 RU https://pubmed.ncbi.nlm.nih.gov/17300166 DMD4V6U DI DMD4V6U DMD4V6U DN D[D-3-Pal2]AVP DMD4V6U MI TT4TFGN DMD4V6U MN Vasopressin V1a receptor (V1AR) DMD4V6U MT DTT DMD4V6U MA Inhibitor DMD4V6U RN Design and synthesis of the first selective agonists for the rat vasopressin V(1b) receptor: based on modifications of deamino-[Cys1]arginine vasop... J Med Chem. 2007 Feb 22;50(4):835-47. DMD4V6U RU https://pubmed.ncbi.nlm.nih.gov/17300166 DMD4V6U DI DMD4V6U DMD4V6U DN D[D-3-Pal2]AVP DMD4V6U MI TTL9MHW DMD4V6U MN Vasopressin V1b receptor (V1BR) DMD4V6U MT DTT DMD4V6U MA Inhibitor DMD4V6U RN Design and synthesis of the first selective agonists for the rat vasopressin V(1b) receptor: based on modifications of deamino-[Cys1]arginine vasop... J Med Chem. 2007 Feb 22;50(4):835-47. DMD4V6U RU https://pubmed.ncbi.nlm.nih.gov/17300166 DMD4V6U DI DMD4V6U DMD4V6U DN D[D-3-Pal2]AVP DMD4V6U MI TTK8R02 DMD4V6U MN Vasopressin V2 receptor (V2R) DMD4V6U MT DTT DMD4V6U MA Inhibitor DMD4V6U RN Design and synthesis of the first selective agonists for the rat vasopressin V(1b) receptor: based on modifications of deamino-[Cys1]arginine vasop... J Med Chem. 2007 Feb 22;50(4):835-47. DMD4V6U RU https://pubmed.ncbi.nlm.nih.gov/17300166 DMNSXG9 DI DMNSXG9 DMNSXG9 DN D[Leu4,Dab8]VP DMNSXG9 MI TTSCIUP DMNSXG9 MN Oxytocin receptor (OTR) DMNSXG9 MT DTT DMNSXG9 MA Inhibitor DMNSXG9 RN Design and synthesis of the first selective agonists for the rat vasopressin V(1b) receptor: based on modifications of deamino-[Cys1]arginine vasop... J Med Chem. 2007 Feb 22;50(4):835-47. DMNSXG9 RU https://pubmed.ncbi.nlm.nih.gov/17300166 DMNSXG9 DI DMNSXG9 DMNSXG9 DN D[Leu4,Dab8]VP DMNSXG9 MI TT4TFGN DMNSXG9 MN Vasopressin V1a receptor (V1AR) DMNSXG9 MT DTT DMNSXG9 MA Inhibitor DMNSXG9 RN Design and synthesis of the first selective agonists for the rat vasopressin V(1b) receptor: based on modifications of deamino-[Cys1]arginine vasop... J Med Chem. 2007 Feb 22;50(4):835-47. DMNSXG9 RU https://pubmed.ncbi.nlm.nih.gov/17300166 DMNSXG9 DI DMNSXG9 DMNSXG9 DN D[Leu4,Dab8]VP DMNSXG9 MI TTL9MHW DMNSXG9 MN Vasopressin V1b receptor (V1BR) DMNSXG9 MT DTT DMNSXG9 MA Inhibitor DMNSXG9 RN Design and synthesis of the first selective agonists for the rat vasopressin V(1b) receptor: based on modifications of deamino-[Cys1]arginine vasop... J Med Chem. 2007 Feb 22;50(4):835-47. DMNSXG9 RU https://pubmed.ncbi.nlm.nih.gov/17300166 DMNSXG9 DI DMNSXG9 DMNSXG9 DN D[Leu4,Dab8]VP DMNSXG9 MI TTK8R02 DMNSXG9 MN Vasopressin V2 receptor (V2R) DMNSXG9 MT DTT DMNSXG9 MA Inhibitor DMNSXG9 RN Design and synthesis of the first selective agonists for the rat vasopressin V(1b) receptor: based on modifications of deamino-[Cys1]arginine vasop... J Med Chem. 2007 Feb 22;50(4):835-47. DMNSXG9 RU https://pubmed.ncbi.nlm.nih.gov/17300166 DME3HK8 DI DME3HK8 DME3HK8 DN D[Leu4,Dap8]VP DME3HK8 MI TTSCIUP DME3HK8 MN Oxytocin receptor (OTR) DME3HK8 MT DTT DME3HK8 MA Inhibitor DME3HK8 RN Design and synthesis of the first selective agonists for the rat vasopressin V(1b) receptor: based on modifications of deamino-[Cys1]arginine vasop... J Med Chem. 2007 Feb 22;50(4):835-47. DME3HK8 RU https://pubmed.ncbi.nlm.nih.gov/17300166 DME3HK8 DI DME3HK8 DME3HK8 DN D[Leu4,Dap8]VP DME3HK8 MI TT4TFGN DME3HK8 MN Vasopressin V1a receptor (V1AR) DME3HK8 MT DTT DME3HK8 MA Inhibitor DME3HK8 RN Design and synthesis of the first selective agonists for the rat vasopressin V(1b) receptor: based on modifications of deamino-[Cys1]arginine vasop... J Med Chem. 2007 Feb 22;50(4):835-47. DME3HK8 RU https://pubmed.ncbi.nlm.nih.gov/17300166 DME3HK8 DI DME3HK8 DME3HK8 DN D[Leu4,Dap8]VP DME3HK8 MI TTL9MHW DME3HK8 MN Vasopressin V1b receptor (V1BR) DME3HK8 MT DTT DME3HK8 MA Inhibitor DME3HK8 RN Design and synthesis of the first selective agonists for the rat vasopressin V(1b) receptor: based on modifications of deamino-[Cys1]arginine vasop... J Med Chem. 2007 Feb 22;50(4):835-47. DME3HK8 RU https://pubmed.ncbi.nlm.nih.gov/17300166 DME3HK8 DI DME3HK8 DME3HK8 DN D[Leu4,Dap8]VP DME3HK8 MI TTK8R02 DME3HK8 MN Vasopressin V2 receptor (V2R) DME3HK8 MT DTT DME3HK8 MA Inhibitor DME3HK8 RN Design and synthesis of the first selective agonists for the rat vasopressin V(1b) receptor: based on modifications of deamino-[Cys1]arginine vasop... J Med Chem. 2007 Feb 22;50(4):835-47. DME3HK8 RU https://pubmed.ncbi.nlm.nih.gov/17300166 DMDBU7Q DI DMDBU7Q DMDBU7Q DN D[Leu4,Lys8]VP DMDBU7Q MI TTSCIUP DMDBU7Q MN Oxytocin receptor (OTR) DMDBU7Q MT DTT DMDBU7Q MA Inhibitor DMDBU7Q RN Design and synthesis of the first selective agonists for the rat vasopressin V(1b) receptor: based on modifications of deamino-[Cys1]arginine vasop... J Med Chem. 2007 Feb 22;50(4):835-47. DMDBU7Q RU https://pubmed.ncbi.nlm.nih.gov/17300166 DMDBU7Q DI DMDBU7Q DMDBU7Q DN D[Leu4,Lys8]VP DMDBU7Q MI TT4TFGN DMDBU7Q MN Vasopressin V1a receptor (V1AR) DMDBU7Q MT DTT DMDBU7Q MA Inhibitor DMDBU7Q RN Design and synthesis of the first selective agonists for the rat vasopressin V(1b) receptor: based on modifications of deamino-[Cys1]arginine vasop... J Med Chem. 2007 Feb 22;50(4):835-47. DMDBU7Q RU https://pubmed.ncbi.nlm.nih.gov/17300166 DMDBU7Q DI DMDBU7Q DMDBU7Q DN D[Leu4,Lys8]VP DMDBU7Q MI TTL9MHW DMDBU7Q MN Vasopressin V1b receptor (V1BR) DMDBU7Q MT DTT DMDBU7Q MA Inhibitor DMDBU7Q RN Design and synthesis of the first selective agonists for the rat vasopressin V(1b) receptor: based on modifications of deamino-[Cys1]arginine vasop... J Med Chem. 2007 Feb 22;50(4):835-47. DMDBU7Q RU https://pubmed.ncbi.nlm.nih.gov/17300166 DMDBU7Q DI DMDBU7Q DMDBU7Q DN D[Leu4,Lys8]VP DMDBU7Q MI TTK8R02 DMDBU7Q MN Vasopressin V2 receptor (V2R) DMDBU7Q MT DTT DMDBU7Q MA Inhibitor DMDBU7Q RN Design and synthesis of the first selective agonists for the rat vasopressin V(1b) receptor: based on modifications of deamino-[Cys1]arginine vasop... J Med Chem. 2007 Feb 22;50(4):835-47. DMDBU7Q RU https://pubmed.ncbi.nlm.nih.gov/17300166 DMJCW8Y DI DMJCW8Y DMJCW8Y DN D[Leu4,Orn8]VP DMJCW8Y MI TTSCIUP DMJCW8Y MN Oxytocin receptor (OTR) DMJCW8Y MT DTT DMJCW8Y MA Inhibitor DMJCW8Y RN Design and synthesis of the first selective agonists for the rat vasopressin V(1b) receptor: based on modifications of deamino-[Cys1]arginine vasop... J Med Chem. 2007 Feb 22;50(4):835-47. DMJCW8Y RU https://pubmed.ncbi.nlm.nih.gov/17300166 DMJCW8Y DI DMJCW8Y DMJCW8Y DN D[Leu4,Orn8]VP DMJCW8Y MI TT4TFGN DMJCW8Y MN Vasopressin V1a receptor (V1AR) DMJCW8Y MT DTT DMJCW8Y MA Inhibitor DMJCW8Y RN Design and synthesis of the first selective agonists for the rat vasopressin V(1b) receptor: based on modifications of deamino-[Cys1]arginine vasop... J Med Chem. 2007 Feb 22;50(4):835-47. DMJCW8Y RU https://pubmed.ncbi.nlm.nih.gov/17300166 DMJCW8Y DI DMJCW8Y DMJCW8Y DN D[Leu4,Orn8]VP DMJCW8Y MI TTL9MHW DMJCW8Y MN Vasopressin V1b receptor (V1BR) DMJCW8Y MT DTT DMJCW8Y MA Inhibitor DMJCW8Y RN Design and synthesis of the first selective agonists for the rat vasopressin V(1b) receptor: based on modifications of deamino-[Cys1]arginine vasop... J Med Chem. 2007 Feb 22;50(4):835-47. DMJCW8Y RU https://pubmed.ncbi.nlm.nih.gov/17300166 DMJCW8Y DI DMJCW8Y DMJCW8Y DN D[Leu4,Orn8]VP DMJCW8Y MI TTK8R02 DMJCW8Y MN Vasopressin V2 receptor (V2R) DMJCW8Y MT DTT DMJCW8Y MA Inhibitor DMJCW8Y RN Design and synthesis of the first selective agonists for the rat vasopressin V(1b) receptor: based on modifications of deamino-[Cys1]arginine vasop... J Med Chem. 2007 Feb 22;50(4):835-47. DMJCW8Y RU https://pubmed.ncbi.nlm.nih.gov/17300166 DMREZT7 DI DMREZT7 DMREZT7 DN D[Leu4]AVP DMREZT7 MI TTSCIUP DMREZT7 MN Oxytocin receptor (OTR) DMREZT7 MT DTT DMREZT7 MA Inhibitor DMREZT7 RN Design and synthesis of the first selective agonists for the rat vasopressin V(1b) receptor: based on modifications of deamino-[Cys1]arginine vasop... J Med Chem. 2007 Feb 22;50(4):835-47. DMREZT7 RU https://pubmed.ncbi.nlm.nih.gov/17300166 DMREZT7 DI DMREZT7 DMREZT7 DN D[Leu4]AVP DMREZT7 MI TT4TFGN DMREZT7 MN Vasopressin V1a receptor (V1AR) DMREZT7 MT DTT DMREZT7 MA Inhibitor DMREZT7 RN Design and synthesis of the first selective agonists for the rat vasopressin V(1b) receptor: based on modifications of deamino-[Cys1]arginine vasop... J Med Chem. 2007 Feb 22;50(4):835-47. DMREZT7 RU https://pubmed.ncbi.nlm.nih.gov/17300166 DMREZT7 DI DMREZT7 DMREZT7 DN D[Leu4]AVP DMREZT7 MI TTL9MHW DMREZT7 MN Vasopressin V1b receptor (V1BR) DMREZT7 MT DTT DMREZT7 MA Inhibitor DMREZT7 RN Design and synthesis of the first selective agonists for the rat vasopressin V(1b) receptor: based on modifications of deamino-[Cys1]arginine vasop... J Med Chem. 2007 Feb 22;50(4):835-47. DMREZT7 RU https://pubmed.ncbi.nlm.nih.gov/17300166 DMREZT7 DI DMREZT7 DMREZT7 DN D[Leu4]AVP DMREZT7 MI TTK8R02 DMREZT7 MN Vasopressin V2 receptor (V2R) DMREZT7 MT DTT DMREZT7 MA Inhibitor DMREZT7 RN Design and synthesis of the first selective agonists for the rat vasopressin V(1b) receptor: based on modifications of deamino-[Cys1]arginine vasop... J Med Chem. 2007 Feb 22;50(4):835-47. DMREZT7 RU https://pubmed.ncbi.nlm.nih.gov/17300166 DME2PKB DI DME2PKB DME2PKB DN D[Lys8(5/6-Flu)]VT DME2PKB MI TTSCIUP DME2PKB MN Oxytocin receptor (OTR) DME2PKB MT DTT DME2PKB MA Inhibitor DME2PKB RN Synthesis and characterization of fluorescent antagonists and agonists for human oxytocin and vasopressin V(1)(a) receptors. J Med Chem. 2002 Jun 6;45(12):2579-88. DME2PKB RU https://pubmed.ncbi.nlm.nih.gov/12036367 DME2PKB DI DME2PKB DME2PKB DN D[Lys8(5/6-Flu)]VT DME2PKB MI TT4TFGN DME2PKB MN Vasopressin V1a receptor (V1AR) DME2PKB MT DTT DME2PKB MA Inhibitor DME2PKB RN Synthesis and characterization of fluorescent antagonists and agonists for human oxytocin and vasopressin V(1)(a) receptors. J Med Chem. 2002 Jun 6;45(12):2579-88. DME2PKB RU https://pubmed.ncbi.nlm.nih.gov/12036367 DME2PKB DI DME2PKB DME2PKB DN D[Lys8(5/6-Flu)]VT DME2PKB MI TTL9MHW DME2PKB MN Vasopressin V1b receptor (V1BR) DME2PKB MT DTT DME2PKB MA Inhibitor DME2PKB RN Synthesis and characterization of fluorescent antagonists and agonists for human oxytocin and vasopressin V(1)(a) receptors. J Med Chem. 2002 Jun 6;45(12):2579-88. DME2PKB RU https://pubmed.ncbi.nlm.nih.gov/12036367 DMNQTBU DI DMNQTBU DMNQTBU DN D[Orn4,Lys8]VP DMNQTBU MI TTSCIUP DMNQTBU MN Oxytocin receptor (OTR) DMNQTBU MT DTT DMNQTBU MA Inhibitor DMNQTBU RN Design and synthesis of the first selective agonists for the rat vasopressin V(1b) receptor: based on modifications of deamino-[Cys1]arginine vasop... J Med Chem. 2007 Feb 22;50(4):835-47. DMNQTBU RU https://pubmed.ncbi.nlm.nih.gov/17300166 DMNQTBU DI DMNQTBU DMNQTBU DN D[Orn4,Lys8]VP DMNQTBU MI TT4TFGN DMNQTBU MN Vasopressin V1a receptor (V1AR) DMNQTBU MT DTT DMNQTBU MA Inhibitor DMNQTBU RN Design and synthesis of the first selective agonists for the rat vasopressin V(1b) receptor: based on modifications of deamino-[Cys1]arginine vasop... J Med Chem. 2007 Feb 22;50(4):835-47. DMNQTBU RU https://pubmed.ncbi.nlm.nih.gov/17300166 DMNQTBU DI DMNQTBU DMNQTBU DN D[Orn4,Lys8]VP DMNQTBU MI TTL9MHW DMNQTBU MN Vasopressin V1b receptor (V1BR) DMNQTBU MT DTT DMNQTBU MA Inhibitor DMNQTBU RN Design and synthesis of the first selective agonists for the rat vasopressin V(1b) receptor: based on modifications of deamino-[Cys1]arginine vasop... J Med Chem. 2007 Feb 22;50(4):835-47. DMNQTBU RU https://pubmed.ncbi.nlm.nih.gov/17300166 DMNQTBU DI DMNQTBU DMNQTBU DN D[Orn4,Lys8]VP DMNQTBU MI TTK8R02 DMNQTBU MN Vasopressin V2 receptor (V2R) DMNQTBU MT DTT DMNQTBU MA Inhibitor DMNQTBU RN Design and synthesis of the first selective agonists for the rat vasopressin V(1b) receptor: based on modifications of deamino-[Cys1]arginine vasop... J Med Chem. 2007 Feb 22;50(4):835-47. DMNQTBU RU https://pubmed.ncbi.nlm.nih.gov/17300166 DMONV0M DI DMONV0M DMONV0M DN D[Orn4,Orn8]VP DMONV0M MI TTSCIUP DMONV0M MN Oxytocin receptor (OTR) DMONV0M MT DTT DMONV0M MA Inhibitor DMONV0M RN Design and synthesis of the first selective agonists for the rat vasopressin V(1b) receptor: based on modifications of deamino-[Cys1]arginine vasop... J Med Chem. 2007 Feb 22;50(4):835-47. DMONV0M RU https://pubmed.ncbi.nlm.nih.gov/17300166 DMONV0M DI DMONV0M DMONV0M DN D[Orn4,Orn8]VP DMONV0M MI TT4TFGN DMONV0M MN Vasopressin V1a receptor (V1AR) DMONV0M MT DTT DMONV0M MA Inhibitor DMONV0M RN Design and synthesis of the first selective agonists for the rat vasopressin V(1b) receptor: based on modifications of deamino-[Cys1]arginine vasop... J Med Chem. 2007 Feb 22;50(4):835-47. DMONV0M RU https://pubmed.ncbi.nlm.nih.gov/17300166 DMONV0M DI DMONV0M DMONV0M DN D[Orn4,Orn8]VP DMONV0M MI TTL9MHW DMONV0M MN Vasopressin V1b receptor (V1BR) DMONV0M MT DTT DMONV0M MA Inhibitor DMONV0M RN Design and synthesis of the first selective agonists for the rat vasopressin V(1b) receptor: based on modifications of deamino-[Cys1]arginine vasop... J Med Chem. 2007 Feb 22;50(4):835-47. DMONV0M RU https://pubmed.ncbi.nlm.nih.gov/17300166 DMONV0M DI DMONV0M DMONV0M DN D[Orn4,Orn8]VP DMONV0M MI TTK8R02 DMONV0M MN Vasopressin V2 receptor (V2R) DMONV0M MT DTT DMONV0M MA Inhibitor DMONV0M RN Design and synthesis of the first selective agonists for the rat vasopressin V(1b) receptor: based on modifications of deamino-[Cys1]arginine vasop... J Med Chem. 2007 Feb 22;50(4):835-47. DMONV0M RU https://pubmed.ncbi.nlm.nih.gov/17300166 DMJNT95 DI DMJNT95 DMJNT95 DN D[Orn4]AVP DMJNT95 MI TTSCIUP DMJNT95 MN Oxytocin receptor (OTR) DMJNT95 MT DTT DMJNT95 MA Inhibitor DMJNT95 RN Design and synthesis of the first selective agonists for the rat vasopressin V(1b) receptor: based on modifications of deamino-[Cys1]arginine vasop... J Med Chem. 2007 Feb 22;50(4):835-47. DMJNT95 RU https://pubmed.ncbi.nlm.nih.gov/17300166 DMJNT95 DI DMJNT95 DMJNT95 DN D[Orn4]AVP DMJNT95 MI TT4TFGN DMJNT95 MN Vasopressin V1a receptor (V1AR) DMJNT95 MT DTT DMJNT95 MA Inhibitor DMJNT95 RN Design and synthesis of the first selective agonists for the rat vasopressin V(1b) receptor: based on modifications of deamino-[Cys1]arginine vasop... J Med Chem. 2007 Feb 22;50(4):835-47. DMJNT95 RU https://pubmed.ncbi.nlm.nih.gov/17300166 DMJNT95 DI DMJNT95 DMJNT95 DN D[Orn4]AVP DMJNT95 MI TTL9MHW DMJNT95 MN Vasopressin V1b receptor (V1BR) DMJNT95 MT DTT DMJNT95 MA Inhibitor DMJNT95 RN Design and synthesis of the first selective agonists for the rat vasopressin V(1b) receptor: based on modifications of deamino-[Cys1]arginine vasop... J Med Chem. 2007 Feb 22;50(4):835-47. DMJNT95 RU https://pubmed.ncbi.nlm.nih.gov/17300166 DMJNT95 DI DMJNT95 DMJNT95 DN D[Orn4]AVP DMJNT95 MI TTK8R02 DMJNT95 MN Vasopressin V2 receptor (V2R) DMJNT95 MT DTT DMJNT95 MA Inhibitor DMJNT95 RN Design and synthesis of the first selective agonists for the rat vasopressin V(1b) receptor: based on modifications of deamino-[Cys1]arginine vasop... J Med Chem. 2007 Feb 22;50(4):835-47. DMJNT95 RU https://pubmed.ncbi.nlm.nih.gov/17300166 DMH791N DI DMH791N DMH791N DN D[Orn8(5/6C-Flu)]VT DMH791N MI TTSCIUP DMH791N MN Oxytocin receptor (OTR) DMH791N MT DTT DMH791N MA Inhibitor DMH791N RN Synthesis and characterization of fluorescent antagonists and agonists for human oxytocin and vasopressin V(1)(a) receptors. J Med Chem. 2002 Jun 6;45(12):2579-88. DMH791N RU https://pubmed.ncbi.nlm.nih.gov/12036367 DMH791N DI DMH791N DMH791N DN D[Orn8(5/6C-Flu)]VT DMH791N MI TT4TFGN DMH791N MN Vasopressin V1a receptor (V1AR) DMH791N MT DTT DMH791N MA Inhibitor DMH791N RN Synthesis and characterization of fluorescent antagonists and agonists for human oxytocin and vasopressin V(1)(a) receptors. J Med Chem. 2002 Jun 6;45(12):2579-88. DMH791N RU https://pubmed.ncbi.nlm.nih.gov/12036367 DMH791N DI DMH791N DMH791N DN D[Orn8(5/6C-Flu)]VT DMH791N MI TTL9MHW DMH791N MN Vasopressin V1b receptor (V1BR) DMH791N MT DTT DMH791N MA Inhibitor DMH791N RN Synthesis and characterization of fluorescent antagonists and agonists for human oxytocin and vasopressin V(1)(a) receptors. J Med Chem. 2002 Jun 6;45(12):2579-88. DMH791N RU https://pubmed.ncbi.nlm.nih.gov/12036367 DMT8KI6 DI DMT8KI6 DMT8KI6 DN d[Pen1,Tyr(Me)2]AVP DMT8KI6 MI TT4TFGN DMT8KI6 MN Vasopressin V1a receptor (V1AR) DMT8KI6 MT DTT DMT8KI6 MA Antagonist DMT8KI6 RN Pharmacological characterization of the human vasopressin receptor subtypes stably expressed in Chinese hamster ovary cells. Br J Pharmacol. 1998 Dec;125(7):1463-70. DMT8KI6 RU https://pubmed.ncbi.nlm.nih.gov/9884074 DMT8KI6 DI DMT8KI6 DMT8KI6 DN d[Pen1,Tyr(Me)2]AVP DMT8KI6 MI TTL9MHW DMT8KI6 MN Vasopressin V1b receptor (V1BR) DMT8KI6 MT DTT DMT8KI6 MA Antagonist DMT8KI6 RN Pharmacological characterization of the human vasopressin receptor subtypes stably expressed in Chinese hamster ovary cells. Br J Pharmacol. 1998 Dec;125(7):1463-70. DMT8KI6 RU https://pubmed.ncbi.nlm.nih.gov/9884074 DMT8KI6 DI DMT8KI6 DMT8KI6 DN d[Pen1,Tyr(Me)2]AVP DMT8KI6 MI TTK8R02 DMT8KI6 MN Vasopressin V2 receptor (V2R) DMT8KI6 MT DTT DMT8KI6 MA Antagonist DMT8KI6 RN Binding properties of a selective tritiated vasopressin V2 receptor antagonist, [H]-SR 121463. Kidney Int. 2000 Oct;58(4):1613-22. DMT8KI6 RU https://pubmed.ncbi.nlm.nih.gov/11012895 DMS4F8O DI DMS4F8O DMS4F8O DN D[Thr4,Lys8(5/6C-Flu)]VT DMS4F8O MI TTSCIUP DMS4F8O MN Oxytocin receptor (OTR) DMS4F8O MT DTT DMS4F8O MA Inhibitor DMS4F8O RN Synthesis and characterization of fluorescent antagonists and agonists for human oxytocin and vasopressin V(1)(a) receptors. J Med Chem. 2002 Jun 6;45(12):2579-88. DMS4F8O RU https://pubmed.ncbi.nlm.nih.gov/12036367 DMS4F8O DI DMS4F8O DMS4F8O DN D[Thr4,Lys8(5/6C-Flu)]VT DMS4F8O MI TT4TFGN DMS4F8O MN Vasopressin V1a receptor (V1AR) DMS4F8O MT DTT DMS4F8O MA Inhibitor DMS4F8O RN Synthesis and characterization of fluorescent antagonists and agonists for human oxytocin and vasopressin V(1)(a) receptors. J Med Chem. 2002 Jun 6;45(12):2579-88. DMS4F8O RU https://pubmed.ncbi.nlm.nih.gov/12036367 DMS4F8O DI DMS4F8O DMS4F8O DN D[Thr4,Lys8(5/6C-Flu)]VT DMS4F8O MI TTL9MHW DMS4F8O MN Vasopressin V1b receptor (V1BR) DMS4F8O MT DTT DMS4F8O MA Inhibitor DMS4F8O RN Synthesis and characterization of fluorescent antagonists and agonists for human oxytocin and vasopressin V(1)(a) receptors. J Med Chem. 2002 Jun 6;45(12):2579-88. DMS4F8O RU https://pubmed.ncbi.nlm.nih.gov/12036367 DMBDZQA DI DMBDZQA DMBDZQA DN D[Thr4,Orn8(5/6C-Flu)]VT DMBDZQA MI TTSCIUP DMBDZQA MN Oxytocin receptor (OTR) DMBDZQA MT DTT DMBDZQA MA Inhibitor DMBDZQA RN Synthesis and characterization of fluorescent antagonists and agonists for human oxytocin and vasopressin V(1)(a) receptors. J Med Chem. 2002 Jun 6;45(12):2579-88. DMBDZQA RU https://pubmed.ncbi.nlm.nih.gov/12036367 DMBDZQA DI DMBDZQA DMBDZQA DN D[Thr4,Orn8(5/6C-Flu)]VT DMBDZQA MI TT4TFGN DMBDZQA MN Vasopressin V1a receptor (V1AR) DMBDZQA MT DTT DMBDZQA MA Inhibitor DMBDZQA RN Synthesis and characterization of fluorescent antagonists and agonists for human oxytocin and vasopressin V(1)(a) receptors. J Med Chem. 2002 Jun 6;45(12):2579-88. DMBDZQA RU https://pubmed.ncbi.nlm.nih.gov/12036367 DMBDZQA DI DMBDZQA DMBDZQA DN D[Thr4,Orn8(5/6C-Flu)]VT DMBDZQA MI TTL9MHW DMBDZQA MN Vasopressin V1b receptor (V1BR) DMBDZQA MT DTT DMBDZQA MA Inhibitor DMBDZQA RN Synthesis and characterization of fluorescent antagonists and agonists for human oxytocin and vasopressin V(1)(a) receptors. J Med Chem. 2002 Jun 6;45(12):2579-88. DMBDZQA RU https://pubmed.ncbi.nlm.nih.gov/12036367 DM3GM8E DI DM3GM8E DM3GM8E DN D[Val4]AVP DM3GM8E MI TTSCIUP DM3GM8E MN Oxytocin receptor (OTR) DM3GM8E MT DTT DM3GM8E MA Inhibitor DM3GM8E RN Design and synthesis of the first selective agonists for the rat vasopressin V(1b) receptor: based on modifications of deamino-[Cys1]arginine vasop... J Med Chem. 2007 Feb 22;50(4):835-47. DM3GM8E RU https://pubmed.ncbi.nlm.nih.gov/17300166 DM3GM8E DI DM3GM8E DM3GM8E DN D[Val4]AVP DM3GM8E MI TT4TFGN DM3GM8E MN Vasopressin V1a receptor (V1AR) DM3GM8E MT DTT DM3GM8E MA Inhibitor DM3GM8E RN Design and synthesis of the first selective agonists for the rat vasopressin V(1b) receptor: based on modifications of deamino-[Cys1]arginine vasop... J Med Chem. 2007 Feb 22;50(4):835-47. DM3GM8E RU https://pubmed.ncbi.nlm.nih.gov/17300166 DM3GM8E DI DM3GM8E DM3GM8E DN D[Val4]AVP DM3GM8E MI TTL9MHW DM3GM8E MN Vasopressin V1b receptor (V1BR) DM3GM8E MT DTT DM3GM8E MA Inhibitor DM3GM8E RN Design and synthesis of the first selective agonists for the rat vasopressin V(1b) receptor: based on modifications of deamino-[Cys1]arginine vasop... J Med Chem. 2007 Feb 22;50(4):835-47. DM3GM8E RU https://pubmed.ncbi.nlm.nih.gov/17300166 DM3GM8E DI DM3GM8E DM3GM8E DN D[Val4]AVP DM3GM8E MI TTK8R02 DM3GM8E MN Vasopressin V2 receptor (V2R) DM3GM8E MT DTT DM3GM8E MA Inhibitor DM3GM8E RN Design and synthesis of the first selective agonists for the rat vasopressin V(1b) receptor: based on modifications of deamino-[Cys1]arginine vasop... J Med Chem. 2007 Feb 22;50(4):835-47. DM3GM8E RU https://pubmed.ncbi.nlm.nih.gov/17300166 DMQJD4P DI DMQJD4P DMQJD4P DN D-166A DMQJD4P MI TTVBI8W DMQJD4P MN Dopamine transporter (DAT) DMQJD4P MT DTT DMQJD4P MA Inhibitor DMQJD4P RN Further structural optimization of cis-(6-benzhydryl-piperidin-3-yl)-benzylamine and 1,4-diazabicyclo[3.3.1]nonane derivatives by introducing an ex... Bioorg Med Chem. 2008 Mar 15;16(6):2769-78. DMQJD4P RU https://pubmed.ncbi.nlm.nih.gov/18249549 DMQJD4P DI DMQJD4P DMQJD4P DN D-166A DMQJD4P MI TTAWNKZ DMQJD4P MN Norepinephrine transporter (NET) DMQJD4P MT DTT DMQJD4P MA Inhibitor DMQJD4P RN Further structural optimization of cis-(6-benzhydryl-piperidin-3-yl)-benzylamine and 1,4-diazabicyclo[3.3.1]nonane derivatives by introducing an ex... Bioorg Med Chem. 2008 Mar 15;16(6):2769-78. DMQJD4P RU https://pubmed.ncbi.nlm.nih.gov/18249549 DMQJD4P DI DMQJD4P DMQJD4P DN D-166A DMQJD4P MI TT3ROYC DMQJD4P MN Serotonin transporter (SERT) DMQJD4P MT DTT DMQJD4P MA Inhibitor DMQJD4P RN Further structural optimization of cis-(6-benzhydryl-piperidin-3-yl)-benzylamine and 1,4-diazabicyclo[3.3.1]nonane derivatives by introducing an ex... Bioorg Med Chem. 2008 Mar 15;16(6):2769-78. DMQJD4P RU https://pubmed.ncbi.nlm.nih.gov/18249549 DMSON1P DI DMSON1P DMSON1P DN D17.4 DMSON1P MI TTYJQTF DMSON1P MN Immunoglobulin E (IgE) DMSON1P MT DTT DMSON1P RN Therapeutic applications of aptamers. Expert Opin Investig Drugs. 2008 Jan;17(1):43-60. DMSON1P RU https://pubmed.ncbi.nlm.nih.gov/18095918 DMU8BJH DI DMU8BJH DMU8BJH DN D-189 DMU8BJH MI TTEX248 DMU8BJH MN Dopamine D2 receptor (D2R) DMU8BJH MT DTT DMU8BJH MA Inhibitor DMU8BJH RN Bioisosteric heterocyclic versions of 7-{[2-(4-phenyl-piperazin-1-yl)ethyl]propylamino}-5,6,7,8-tetrahydronaphthalen-2-ol: identification of highly... J Med Chem. 2008 May 22;51(10):3005-19. DMU8BJH RU https://pubmed.ncbi.nlm.nih.gov/18410082 DMU8BJH DI DMU8BJH DMU8BJH DN D-189 DMU8BJH MI TT4C8EA DMU8BJH MN Dopamine D3 receptor (D3R) DMU8BJH MT DTT DMU8BJH MA Inhibitor DMU8BJH RN Bioisosteric heterocyclic versions of 7-{[2-(4-phenyl-piperazin-1-yl)ethyl]propylamino}-5,6,7,8-tetrahydronaphthalen-2-ol: identification of highly... J Med Chem. 2008 May 22;51(10):3005-19. DMU8BJH RU https://pubmed.ncbi.nlm.nih.gov/18410082 DMUMNSW DI DMUMNSW DMUMNSW DN D-190 DMUMNSW MI TTEX248 DMUMNSW MN Dopamine D2 receptor (D2R) DMUMNSW MT DTT DMUMNSW MA Inhibitor DMUMNSW RN Bioisosteric heterocyclic versions of 7-{[2-(4-phenyl-piperazin-1-yl)ethyl]propylamino}-5,6,7,8-tetrahydronaphthalen-2-ol: identification of highly... J Med Chem. 2008 May 22;51(10):3005-19. DMUMNSW RU https://pubmed.ncbi.nlm.nih.gov/18410082 DMUMNSW DI DMUMNSW DMUMNSW DN D-190 DMUMNSW MI TT4C8EA DMUMNSW MN Dopamine D3 receptor (D3R) DMUMNSW MT DTT DMUMNSW MA Inhibitor DMUMNSW RN Bioisosteric heterocyclic versions of 7-{[2-(4-phenyl-piperazin-1-yl)ethyl]propylamino}-5,6,7,8-tetrahydronaphthalen-2-ol: identification of highly... J Med Chem. 2008 May 22;51(10):3005-19. DMUMNSW RU https://pubmed.ncbi.nlm.nih.gov/18410082 DM8D26T DI DM8D26T DM8D26T DN D-192 DM8D26T MI TTEX248 DM8D26T MN Dopamine D2 receptor (D2R) DM8D26T MT DTT DM8D26T MA Inhibitor DM8D26T RN Bioisosteric heterocyclic versions of 7-{[2-(4-phenyl-piperazin-1-yl)ethyl]propylamino}-5,6,7,8-tetrahydronaphthalen-2-ol: identification of highly... J Med Chem. 2008 May 22;51(10):3005-19. DM8D26T RU https://pubmed.ncbi.nlm.nih.gov/18410082 DM8D26T DI DM8D26T DM8D26T DN D-192 DM8D26T MI TT4C8EA DM8D26T MN Dopamine D3 receptor (D3R) DM8D26T MT DTT DM8D26T MA Inhibitor DM8D26T RN Bioisosteric heterocyclic versions of 7-{[2-(4-phenyl-piperazin-1-yl)ethyl]propylamino}-5,6,7,8-tetrahydronaphthalen-2-ol: identification of highly... J Med Chem. 2008 May 22;51(10):3005-19. DM8D26T RU https://pubmed.ncbi.nlm.nih.gov/18410082 DMU83T7 DI DMU83T7 DMU83T7 DN D-193 DMU83T7 MI TTEX248 DMU83T7 MN Dopamine D2 receptor (D2R) DMU83T7 MT DTT DMU83T7 MA Inhibitor DMU83T7 RN Bioisosteric heterocyclic versions of 7-{[2-(4-phenyl-piperazin-1-yl)ethyl]propylamino}-5,6,7,8-tetrahydronaphthalen-2-ol: identification of highly... J Med Chem. 2008 May 22;51(10):3005-19. DMU83T7 RU https://pubmed.ncbi.nlm.nih.gov/18410082 DMU83T7 DI DMU83T7 DMU83T7 DN D-193 DMU83T7 MI TT4C8EA DMU83T7 MN Dopamine D3 receptor (D3R) DMU83T7 MT DTT DMU83T7 MA Inhibitor DMU83T7 RN Bioisosteric heterocyclic versions of 7-{[2-(4-phenyl-piperazin-1-yl)ethyl]propylamino}-5,6,7,8-tetrahydronaphthalen-2-ol: identification of highly... J Med Chem. 2008 May 22;51(10):3005-19. DMU83T7 RU https://pubmed.ncbi.nlm.nih.gov/18410082 DMKPIH0 DI DMKPIH0 DMKPIH0 DN D-203 DMKPIH0 MI TTEX248 DMKPIH0 MN Dopamine D2 receptor (D2R) DMKPIH0 MT DTT DMKPIH0 MA Inhibitor DMKPIH0 RN Bioisosteric heterocyclic versions of 7-{[2-(4-phenyl-piperazin-1-yl)ethyl]propylamino}-5,6,7,8-tetrahydronaphthalen-2-ol: identification of highly... J Med Chem. 2008 May 22;51(10):3005-19. DMKPIH0 RU https://pubmed.ncbi.nlm.nih.gov/18410082 DMKPIH0 DI DMKPIH0 DMKPIH0 DN D-203 DMKPIH0 MI TT4C8EA DMKPIH0 MN Dopamine D3 receptor (D3R) DMKPIH0 MT DTT DMKPIH0 MA Inhibitor DMKPIH0 RN Bioisosteric heterocyclic versions of 7-{[2-(4-phenyl-piperazin-1-yl)ethyl]propylamino}-5,6,7,8-tetrahydronaphthalen-2-ol: identification of highly... J Med Chem. 2008 May 22;51(10):3005-19. DMKPIH0 RU https://pubmed.ncbi.nlm.nih.gov/18410082 DMNLE4S DI DMNLE4S DMNLE4S DN D-210 DMNLE4S MI TTEX248 DMNLE4S MN Dopamine D2 receptor (D2R) DMNLE4S MT DTT DMNLE4S MA Inhibitor DMNLE4S RN Bioisosteric heterocyclic versions of 7-{[2-(4-phenyl-piperazin-1-yl)ethyl]propylamino}-5,6,7,8-tetrahydronaphthalen-2-ol: identification of highly... J Med Chem. 2008 May 22;51(10):3005-19. DMNLE4S RU https://pubmed.ncbi.nlm.nih.gov/18410082 DMNLE4S DI DMNLE4S DMNLE4S DN D-210 DMNLE4S MI TT4C8EA DMNLE4S MN Dopamine D3 receptor (D3R) DMNLE4S MT DTT DMNLE4S MA Inhibitor DMNLE4S RN Bioisosteric heterocyclic versions of 7-{[2-(4-phenyl-piperazin-1-yl)ethyl]propylamino}-5,6,7,8-tetrahydronaphthalen-2-ol: identification of highly... J Med Chem. 2008 May 22;51(10):3005-19. DMNLE4S RU https://pubmed.ncbi.nlm.nih.gov/18410082 DMIBOAK DI DMIBOAK DMIBOAK DN D-211A DMIBOAK MI TTVBI8W DMIBOAK MN Dopamine transporter (DAT) DMIBOAK MT DTT DMIBOAK MA Inhibitor DMIBOAK RN Further structural optimization of cis-(6-benzhydryl-piperidin-3-yl)-benzylamine and 1,4-diazabicyclo[3.3.1]nonane derivatives by introducing an ex... Bioorg Med Chem. 2008 Mar 15;16(6):2769-78. DMIBOAK RU https://pubmed.ncbi.nlm.nih.gov/18249549 DMIBOAK DI DMIBOAK DMIBOAK DN D-211A DMIBOAK MI TTAWNKZ DMIBOAK MN Norepinephrine transporter (NET) DMIBOAK MT DTT DMIBOAK MA Inhibitor DMIBOAK RN Further structural optimization of cis-(6-benzhydryl-piperidin-3-yl)-benzylamine and 1,4-diazabicyclo[3.3.1]nonane derivatives by introducing an ex... Bioorg Med Chem. 2008 Mar 15;16(6):2769-78. DMIBOAK RU https://pubmed.ncbi.nlm.nih.gov/18249549 DMIBOAK DI DMIBOAK DMIBOAK DN D-211A DMIBOAK MI TT3ROYC DMIBOAK MN Serotonin transporter (SERT) DMIBOAK MT DTT DMIBOAK MA Inhibitor DMIBOAK RN Further structural optimization of cis-(6-benzhydryl-piperidin-3-yl)-benzylamine and 1,4-diazabicyclo[3.3.1]nonane derivatives by introducing an ex... Bioorg Med Chem. 2008 Mar 15;16(6):2769-78. DMIBOAK RU https://pubmed.ncbi.nlm.nih.gov/18249549 DM54CKZ DI DM54CKZ DM54CKZ DN D-211B DM54CKZ MI TTVBI8W DM54CKZ MN Dopamine transporter (DAT) DM54CKZ MT DTT DM54CKZ MA Inhibitor DM54CKZ RN Further structural optimization of cis-(6-benzhydryl-piperidin-3-yl)-benzylamine and 1,4-diazabicyclo[3.3.1]nonane derivatives by introducing an ex... Bioorg Med Chem. 2008 Mar 15;16(6):2769-78. DM54CKZ RU https://pubmed.ncbi.nlm.nih.gov/18249549 DM54CKZ DI DM54CKZ DM54CKZ DN D-211B DM54CKZ MI TTAWNKZ DM54CKZ MN Norepinephrine transporter (NET) DM54CKZ MT DTT DM54CKZ MA Inhibitor DM54CKZ RN Further structural optimization of cis-(6-benzhydryl-piperidin-3-yl)-benzylamine and 1,4-diazabicyclo[3.3.1]nonane derivatives by introducing an ex... Bioorg Med Chem. 2008 Mar 15;16(6):2769-78. DM54CKZ RU https://pubmed.ncbi.nlm.nih.gov/18249549 DM54CKZ DI DM54CKZ DM54CKZ DN D-211B DM54CKZ MI TT3ROYC DM54CKZ MN Serotonin transporter (SERT) DM54CKZ MT DTT DM54CKZ MA Inhibitor DM54CKZ RN Further structural optimization of cis-(6-benzhydryl-piperidin-3-yl)-benzylamine and 1,4-diazabicyclo[3.3.1]nonane derivatives by introducing an ex... Bioorg Med Chem. 2008 Mar 15;16(6):2769-78. DM54CKZ RU https://pubmed.ncbi.nlm.nih.gov/18249549 DMQLT84 DI DMQLT84 DMQLT84 DN D-218 DMQLT84 MI TTEX248 DMQLT84 MN Dopamine D2 receptor (D2R) DMQLT84 MT DTT DMQLT84 MA Inhibitor DMQLT84 RN Bioisosteric heterocyclic versions of 7-{[2-(4-phenyl-piperazin-1-yl)ethyl]propylamino}-5,6,7,8-tetrahydronaphthalen-2-ol: identification of highly... J Med Chem. 2008 May 22;51(10):3005-19. DMQLT84 RU https://pubmed.ncbi.nlm.nih.gov/18410082 DMQLT84 DI DMQLT84 DMQLT84 DN D-218 DMQLT84 MI TT4C8EA DMQLT84 MN Dopamine D3 receptor (D3R) DMQLT84 MT DTT DMQLT84 MA Inhibitor DMQLT84 RN Bioisosteric heterocyclic versions of 7-{[2-(4-phenyl-piperazin-1-yl)ethyl]propylamino}-5,6,7,8-tetrahydronaphthalen-2-ol: identification of highly... J Med Chem. 2008 May 22;51(10):3005-19. DMQLT84 RU https://pubmed.ncbi.nlm.nih.gov/18410082 DMQ2U4G DI DMQ2U4G DMQ2U4G DN D-219 DMQ2U4G MI TTEX248 DMQ2U4G MN Dopamine D2 receptor (D2R) DMQ2U4G MT DTT DMQ2U4G MA Inhibitor DMQ2U4G RN Bioisosteric heterocyclic versions of 7-{[2-(4-phenyl-piperazin-1-yl)ethyl]propylamino}-5,6,7,8-tetrahydronaphthalen-2-ol: identification of highly... J Med Chem. 2008 May 22;51(10):3005-19. DMQ2U4G RU https://pubmed.ncbi.nlm.nih.gov/18410082 DMQ2U4G DI DMQ2U4G DMQ2U4G DN D-219 DMQ2U4G MI TT4C8EA DMQ2U4G MN Dopamine D3 receptor (D3R) DMQ2U4G MT DTT DMQ2U4G MA Inhibitor DMQ2U4G RN Bioisosteric heterocyclic versions of 7-{[2-(4-phenyl-piperazin-1-yl)ethyl]propylamino}-5,6,7,8-tetrahydronaphthalen-2-ol: identification of highly... J Med Chem. 2008 May 22;51(10):3005-19. DMQ2U4G RU https://pubmed.ncbi.nlm.nih.gov/18410082 DMTUJWN DI DMTUJWN DMTUJWN DN D-220 DMTUJWN MI TTEX248 DMTUJWN MN Dopamine D2 receptor (D2R) DMTUJWN MT DTT DMTUJWN MA Inhibitor DMTUJWN RN Bioisosteric heterocyclic versions of 7-{[2-(4-phenyl-piperazin-1-yl)ethyl]propylamino}-5,6,7,8-tetrahydronaphthalen-2-ol: identification of highly... J Med Chem. 2008 May 22;51(10):3005-19. DMTUJWN RU https://pubmed.ncbi.nlm.nih.gov/18410082 DMTUJWN DI DMTUJWN DMTUJWN DN D-220 DMTUJWN MI TT4C8EA DMTUJWN MN Dopamine D3 receptor (D3R) DMTUJWN MT DTT DMTUJWN MA Inhibitor DMTUJWN RN Bioisosteric heterocyclic versions of 7-{[2-(4-phenyl-piperazin-1-yl)ethyl]propylamino}-5,6,7,8-tetrahydronaphthalen-2-ol: identification of highly... J Med Chem. 2008 May 22;51(10):3005-19. DMTUJWN RU https://pubmed.ncbi.nlm.nih.gov/18410082 DMGA48T DI DMGA48T DMGA48T DN D-237 DMGA48T MI TTEX248 DMGA48T MN Dopamine D2 receptor (D2R) DMGA48T MT DTT DMGA48T MA Inhibitor DMGA48T RN Structurally constrained hybrid derivatives containing octahydrobenzo[g or f]quinoline moieties for dopamine D2 and D3 receptors: binding character... J Med Chem. 2008 Dec 25;51(24):7806-19. DMGA48T RU https://pubmed.ncbi.nlm.nih.gov/19053758 DMGA48T DI DMGA48T DMGA48T DN D-237 DMGA48T MI TT4C8EA DMGA48T MN Dopamine D3 receptor (D3R) DMGA48T MT DTT DMGA48T MA Inhibitor DMGA48T RN Structurally constrained hybrid derivatives containing octahydrobenzo[g or f]quinoline moieties for dopamine D2 and D3 receptors: binding character... J Med Chem. 2008 Dec 25;51(24):7806-19. DMGA48T RU https://pubmed.ncbi.nlm.nih.gov/19053758 DM6KFCO DI DM6KFCO DM6KFCO DN D-254C DM6KFCO MI TTVBI8W DM6KFCO MN Dopamine transporter (DAT) DM6KFCO MT DTT DM6KFCO MA Inhibitor DM6KFCO RN Further structural optimization of cis-(6-benzhydryl-piperidin-3-yl)-benzylamine and 1,4-diazabicyclo[3.3.1]nonane derivatives by introducing an ex... Bioorg Med Chem. 2008 Mar 15;16(6):2769-78. DM6KFCO RU https://pubmed.ncbi.nlm.nih.gov/18249549 DM6KFCO DI DM6KFCO DM6KFCO DN D-254C DM6KFCO MI TTAWNKZ DM6KFCO MN Norepinephrine transporter (NET) DM6KFCO MT DTT DM6KFCO MA Inhibitor DM6KFCO RN Further structural optimization of cis-(6-benzhydryl-piperidin-3-yl)-benzylamine and 1,4-diazabicyclo[3.3.1]nonane derivatives by introducing an ex... Bioorg Med Chem. 2008 Mar 15;16(6):2769-78. DM6KFCO RU https://pubmed.ncbi.nlm.nih.gov/18249549 DM6KFCO DI DM6KFCO DM6KFCO DN D-254C DM6KFCO MI TT3ROYC DM6KFCO MN Serotonin transporter (SERT) DM6KFCO MT DTT DM6KFCO MA Inhibitor DM6KFCO RN Further structural optimization of cis-(6-benzhydryl-piperidin-3-yl)-benzylamine and 1,4-diazabicyclo[3.3.1]nonane derivatives by introducing an ex... Bioorg Med Chem. 2008 Mar 15;16(6):2769-78. DM6KFCO RU https://pubmed.ncbi.nlm.nih.gov/18249549 DMN7E6Y DI DMN7E6Y DMN7E6Y DN D-257A DMN7E6Y MI TTVBI8W DMN7E6Y MN Dopamine transporter (DAT) DMN7E6Y MT DTT DMN7E6Y MA Inhibitor DMN7E6Y RN Further structural optimization of cis-(6-benzhydryl-piperidin-3-yl)-benzylamine and 1,4-diazabicyclo[3.3.1]nonane derivatives by introducing an ex... Bioorg Med Chem. 2008 Mar 15;16(6):2769-78. DMN7E6Y RU https://pubmed.ncbi.nlm.nih.gov/18249549 DMN7E6Y DI DMN7E6Y DMN7E6Y DN D-257A DMN7E6Y MI TTAWNKZ DMN7E6Y MN Norepinephrine transporter (NET) DMN7E6Y MT DTT DMN7E6Y MA Inhibitor DMN7E6Y RN Further structural optimization of cis-(6-benzhydryl-piperidin-3-yl)-benzylamine and 1,4-diazabicyclo[3.3.1]nonane derivatives by introducing an ex... Bioorg Med Chem. 2008 Mar 15;16(6):2769-78. DMN7E6Y RU https://pubmed.ncbi.nlm.nih.gov/18249549 DMN7E6Y DI DMN7E6Y DMN7E6Y DN D-257A DMN7E6Y MI TT3ROYC DMN7E6Y MN Serotonin transporter (SERT) DMN7E6Y MT DTT DMN7E6Y MA Inhibitor DMN7E6Y RN Further structural optimization of cis-(6-benzhydryl-piperidin-3-yl)-benzylamine and 1,4-diazabicyclo[3.3.1]nonane derivatives by introducing an ex... Bioorg Med Chem. 2008 Mar 15;16(6):2769-78. DMN7E6Y RU https://pubmed.ncbi.nlm.nih.gov/18249549 DM5GLJ2 DI DM5GLJ2 DM5GLJ2 DN D-257C DM5GLJ2 MI TTVBI8W DM5GLJ2 MN Dopamine transporter (DAT) DM5GLJ2 MT DTT DM5GLJ2 MA Inhibitor DM5GLJ2 RN Further structural optimization of cis-(6-benzhydryl-piperidin-3-yl)-benzylamine and 1,4-diazabicyclo[3.3.1]nonane derivatives by introducing an ex... Bioorg Med Chem. 2008 Mar 15;16(6):2769-78. DM5GLJ2 RU https://pubmed.ncbi.nlm.nih.gov/18249549 DM5GLJ2 DI DM5GLJ2 DM5GLJ2 DN D-257C DM5GLJ2 MI TTAWNKZ DM5GLJ2 MN Norepinephrine transporter (NET) DM5GLJ2 MT DTT DM5GLJ2 MA Inhibitor DM5GLJ2 RN Further structural optimization of cis-(6-benzhydryl-piperidin-3-yl)-benzylamine and 1,4-diazabicyclo[3.3.1]nonane derivatives by introducing an ex... Bioorg Med Chem. 2008 Mar 15;16(6):2769-78. DM5GLJ2 RU https://pubmed.ncbi.nlm.nih.gov/18249549 DM5GLJ2 DI DM5GLJ2 DM5GLJ2 DN D-257C DM5GLJ2 MI TT3ROYC DM5GLJ2 MN Serotonin transporter (SERT) DM5GLJ2 MT DTT DM5GLJ2 MA Inhibitor DM5GLJ2 RN Further structural optimization of cis-(6-benzhydryl-piperidin-3-yl)-benzylamine and 1,4-diazabicyclo[3.3.1]nonane derivatives by introducing an ex... Bioorg Med Chem. 2008 Mar 15;16(6):2769-78. DM5GLJ2 RU https://pubmed.ncbi.nlm.nih.gov/18249549 DMWLHBQ DI DMWLHBQ DMWLHBQ DN D-264 DMWLHBQ MI TTEX248 DMWLHBQ MN Dopamine D2 receptor (D2R) DMWLHBQ MT DTT DMWLHBQ MA Inhibitor DMWLHBQ RN Investigation of various N-heterocyclic substituted piperazine versions of 5/7-{[2-(4-aryl-piperazin-1-yl)-ethyl]-propyl-amino}-5,6,7,8-tetrahydro-... Bioorg Med Chem. 2009 Jun 1;17(11):3923-33. DMWLHBQ RU https://pubmed.ncbi.nlm.nih.gov/19427222 DMWLHBQ DI DMWLHBQ DMWLHBQ DN D-264 DMWLHBQ MI TT4C8EA DMWLHBQ MN Dopamine D3 receptor (D3R) DMWLHBQ MT DTT DMWLHBQ MA Inhibitor DMWLHBQ RN Investigation of various N-heterocyclic substituted piperazine versions of 5/7-{[2-(4-aryl-piperazin-1-yl)-ethyl]-propyl-amino}-5,6,7,8-tetrahydro-... Bioorg Med Chem. 2009 Jun 1;17(11):3923-33. DMWLHBQ RU https://pubmed.ncbi.nlm.nih.gov/19427222 DMG1CD5 DI DMG1CD5 DMG1CD5 DN D-315 DMG1CD5 MI TTEX248 DMG1CD5 MN Dopamine D2 receptor (D2R) DMG1CD5 MT DTT DMG1CD5 MA Inhibitor DMG1CD5 RN Further delineation of hydrophobic binding sites in dopamine D(2)/D(3) receptors for N-4 substituents on the piperazine ring of the hybrid template... Bioorg Med Chem. 2010 Aug 1;18(15):5661-74. DMG1CD5 RU https://pubmed.ncbi.nlm.nih.gov/20605099 DMG1CD5 DI DMG1CD5 DMG1CD5 DN D-315 DMG1CD5 MI TT4C8EA DMG1CD5 MN Dopamine D3 receptor (D3R) DMG1CD5 MT DTT DMG1CD5 MA Inhibitor DMG1CD5 RN Further delineation of hydrophobic binding sites in dopamine D(2)/D(3) receptors for N-4 substituents on the piperazine ring of the hybrid template... Bioorg Med Chem. 2010 Aug 1;18(15):5661-74. DMG1CD5 RU https://pubmed.ncbi.nlm.nih.gov/20605099 DMZAM3G DI DMZAM3G DMZAM3G DN D-366 DMZAM3G MI TTEX248 DMZAM3G MN Dopamine D2 receptor (D2R) DMZAM3G MT DTT DMZAM3G MA Inhibitor DMZAM3G RN Development of (S)-N6-(2-(4-(isoquinolin-1-yl)piperazin-1-yl)ethyl)-N6-propyl-4,5,6,7-tetrahydrobenzo[d]-thiazole-2,6-diamine and its analogue as a... J Med Chem. 2010 Feb 11;53(3):1023-37. DMZAM3G RU https://pubmed.ncbi.nlm.nih.gov/20038106 DMZAM3G DI DMZAM3G DMZAM3G DN D-366 DMZAM3G MI TT4C8EA DMZAM3G MN Dopamine D3 receptor (D3R) DMZAM3G MT DTT DMZAM3G MA Inhibitor DMZAM3G RN Development of (S)-N6-(2-(4-(isoquinolin-1-yl)piperazin-1-yl)ethyl)-N6-propyl-4,5,6,7-tetrahydrobenzo[d]-thiazole-2,6-diamine and its analogue as a... J Med Chem. 2010 Feb 11;53(3):1023-37. DMZAM3G RU https://pubmed.ncbi.nlm.nih.gov/20038106 DM048OG DI DM048OG DM048OG DN D-420720 DM048OG MI TTDIGC1 DM048OG MN Dipeptidyl peptidase 4 (DPP-4) DM048OG MT DTT DM048OG MA Inhibitor DM048OG RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1612). DM048OG RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1612 DM0M81E DI DM0M81E DM0M81E DN D609 DM0M81E MI TT6ERZB DM0M81E MN Bacterial Phosphatidylcholine-specificphospholipase C (Bact plcN) DM0M81E MT DTT DM0M81E MA Inhibitor DM0M81E RN Function of the p55 tumor necrosis factor receptor "death domain" mediated by phosphatidylcholine-specific phospholipase C. J Exp Med. 1996 Aug 1;184(2):725-33. DM0M81E RU https://pubmed.ncbi.nlm.nih.gov/8760826 DM0A54V DI DM0A54V DM0A54V DN D-65476 DM0A54V MI TT8FYO9 DM0A54V MN Platelet-derived growth factor receptor alpha (PDGFRA) DM0A54V MT DTT DM0A54V MA Inhibitor DM0A54V RN Bis(1H-2-indolyl)methanones as a novel class of inhibitors of the platelet-derived growth factor receptor kinase. J Med Chem. 2002 Feb 28;45(5):1002-18. DM0A54V RU https://pubmed.ncbi.nlm.nih.gov/11855980 DM54T8J DI DM54T8J DM54T8J DN DAB-486-IL-2 DM54T8J MI TT9721Y DM54T8J MN Interleukin 2 receptor beta (IL2RB) DM54T8J MT DTT DM54T8J MA Modulator DM54T8J RN Interleukin 2 receptor targeted fusion toxin (DAB486-IL-2) treatment blocks diabetogenic autoimmunity in non-obese diabetic mice. Eur J Immunol. 1992 Mar;22(3):697-702. DM54T8J RU https://www.ncbi.nlm.nih.gov/pubmed/1547815 DMHZKMG DI DMHZKMG DMHZKMG DN DABCO DMHZKMG MI TTODZF1 DMHZKMG MN Voltage-gated potassium channel Kv3.4 (KCNC4) DMHZKMG MT DTT DMHZKMG MA Blocker (channel blocker) DMHZKMG RN 1,4-Diazabicyclo[2.2.2]octane derivatives: a novel class of voltage-gated potassium channel blockers. Mol Pharmacol. 2006 Mar;69(3):718-26. DMHZKMG RU https://pubmed.ncbi.nlm.nih.gov/16317109 DMN3GTF DI DMN3GTF DMN3GTF DN DABCO-C16 DMN3GTF MI TT5OEKU DMN3GTF MN Voltage-gated potassium channel Kv2.1 (KCNB1) DMN3GTF MT DTT DMN3GTF MA Blocker (channel blocker) DMN3GTF RN 1,4-Diazabicyclo[2.2.2]octane derivatives: a novel class of voltage-gated potassium channel blockers. Mol Pharmacol. 2006 Mar;69(3):718-26. DMN3GTF RU https://pubmed.ncbi.nlm.nih.gov/16317109 DMN3GTF DI DMN3GTF DMN3GTF DN DABCO-C16 DMN3GTF MI TTODZF1 DMN3GTF MN Voltage-gated potassium channel Kv3.4 (KCNC4) DMN3GTF MT DTT DMN3GTF MA Blocker (channel blocker) DMN3GTF RN 1,4-Diazabicyclo[2.2.2]octane derivatives: a novel class of voltage-gated potassium channel blockers. Mol Pharmacol. 2006 Mar;69(3):718-26. DMN3GTF RU https://pubmed.ncbi.nlm.nih.gov/16317109 DMCNAME DI DMCNAME DMCNAME DN DACTHF DMCNAME MI DECWT2V DMCNAME MN Folylpolyglutamate synthase (FPGS) DMCNAME MT DME DMCNAME MA Metabolism DMCNAME RN Role of folylpolyglutamate synthetase in the metabolism and cytotoxicity of 5-deazaacyclotetrahydrofolate, an anti-purine drug. J Biol Chem. 1994 Apr 1;269(13):9714-20. DMCNAME RU https://www.ncbi.nlm.nih.gov/pubmed/?term=8144562 DMRM0OW DI DMRM0OW DMRM0OW DN Dadle DMRM0OW MI TT27RFC DMRM0OW MN Opioid receptor delta (OPRD1) DMRM0OW MT DTT DMRM0OW MA Agonist DMRM0OW RN Delta opioid receptor stimulation mimics ischemic preconditioning in human heart muscle. J Am Coll Cardiol. 2000 Dec;36(7):2296-302. DMRM0OW RU https://pubmed.ncbi.nlm.nih.gov/11127476 DMRM0OW DI DMRM0OW DMRM0OW DN Dadle DMRM0OW MI TTKWM86 DMRM0OW MN Opioid receptor mu (MOP) DMRM0OW MT DTT DMRM0OW MA Inhibitor DMRM0OW RN Design, synthesis, and biological evaluation of novel bifunctional C-terminal-modified peptides for delta/mu opioid receptor agonists and neurokini... J Med Chem. 2007 Jun 14;50(12):2779-86. DMRM0OW RU https://pubmed.ncbi.nlm.nih.gov/17516639 DMRM0OW DI DMRM0OW DMRM0OW DN Dadle DMRM0OW MI DT3D8F0 DMRM0OW MN Organic anion transporting polypeptide 1B1 (SLCO1B1) DMRM0OW MT DTP DMRM0OW MA Substrate DMRM0OW RN Organic anion transporting polypeptide 1B1: a genetically polymorphic transporter of major importance for hepatic drug uptake. Pharmacol Rev. 2011 Mar;63(1):157-81. DMRM0OW RU http://www.ncbi.nlm.nih.gov/pubmed/21245207 DMJIFY3 DI DMJIFY3 DMJIFY3 DN DADMe-ImmG DMJIFY3 MI TTMCF1Y DMJIFY3 MN Purine nucleoside phosphorylase (PNP) DMJIFY3 MT DTT DMJIFY3 MA Inhibitor DMJIFY3 RN Achieving the ultimate physiological goal in transition state analogue inhibitors for purine nucleoside phosphorylase. J Biol Chem. 2003 Aug 22;278(34):31465-8. DMJIFY3 RU https://pubmed.ncbi.nlm.nih.gov/12842889 DMWR3XL DI DMWR3XL DMWR3XL DN DAEDALIN A DMWR3XL MI TTULVH8 DMWR3XL MN Tyrosinase (TYR) DMWR3XL MT DTT DMWR3XL MA Inhibitor DMWR3XL RN Asymmetric syntheses of daedalin A and quercinol and their tyrosinase inhibitory activity. Bioorg Med Chem Lett. 2010 Feb 1;20(3):1063-4. DMWR3XL RU https://pubmed.ncbi.nlm.nih.gov/20036119 DMRFTJX DI DMRFTJX DMRFTJX DN Daidzein DMRFTJX MI TTFBNVI DMRFTJX MN Aldose reductase (AKR1B1) DMRFTJX MT DTT DMRFTJX MA Inhibitor DMRFTJX RN 1-Benzopyran-4-one antioxidants as aldose reductase inhibitors. J Med Chem. 1999 Jun 3;42(11):1881-93. DMRFTJX RU https://pubmed.ncbi.nlm.nih.gov/10354396 DMRFTJX DI DMRFTJX DMRFTJX DN Daidzein DMRFTJX MI DTI7UX6 DMRFTJX MN Breast cancer resistance protein (ABCG2) DMRFTJX MT DTP DMRFTJX MA Substrate DMRFTJX RN Effect of breast cancer resistance protein (Bcrp/Abcg2) on the disposition of phytoestrogens. Mol Pharmacol. 2007 Oct;72(4):967-75. DMRFTJX RU https://doi.org/10.1124/mol.107.034751 DMRFTJX DI DMRFTJX DMRFTJX DN Daidzein DMRFTJX MI DEUWAV0 DMRFTJX MN Cytochrome P450 102D1 (cyp102) DMRFTJX MT DME DMRFTJX MA Metabolism DMRFTJX RN The metagenome of Caracolus marginella gut microbiome using culture independent approaches and shotgun sequencing. Data Brief. 2017 Nov 22;16:501-505. DMRFTJX RU https://pubmed.ncbi.nlm.nih.gov/29270447 DMRFTJX DI DMRFTJX DMRFTJX DN Daidzein DMRFTJX MI TTZAYWL DMRFTJX MN Estrogen receptor (ESR) DMRFTJX MT DTT DMRFTJX MA Inhibitor DMRFTJX RN Isolation and structure elucidation of an isoflavone and a sesterterpenoic acid from Henriettella fascicularis. J Nat Prod. 2002 Dec;65(12):1749-53. DMRFTJX RU https://pubmed.ncbi.nlm.nih.gov/12502307 DMRFTJX DI DMRFTJX DMRFTJX DN Daidzein DMRFTJX MI TTOM3J0 DMRFTJX MN Estrogen receptor beta (ESR2) DMRFTJX MT DTT DMRFTJX MA Inhibitor DMRFTJX RN Isolation and structure elucidation of an isoflavone and a sesterterpenoic acid from Henriettella fascicularis. J Nat Prod. 2002 Dec;65(12):1749-53. DMRFTJX RU https://pubmed.ncbi.nlm.nih.gov/12502307 DMRFTJX DI DMRFTJX DMRFTJX DN Daidzein DMRFTJX MI TTPNQAC DMRFTJX MN Estrogen-related receptor-alpha (ESRRA) DMRFTJX MT DTT DMRFTJX MA Agonist DMRFTJX RN Flavone and isoflavone phytoestrogens are agonists of estrogen-related receptors. Mol Cancer Res. 2003 Nov;1(13):981-91. DMRFTJX RU https://pubmed.ncbi.nlm.nih.gov/14638870 DMRFTJX DI DMRFTJX DMRFTJX DN Daidzein DMRFTJX MI TTKF0XS DMRFTJX MN Estrogen-related receptor-beta (ESRRB) DMRFTJX MT DTT DMRFTJX MA Agonist DMRFTJX RN Flavone and isoflavone phytoestrogens are agonists of estrogen-related receptors. Mol Cancer Res. 2003 Nov;1(13):981-91. DMRFTJX RU https://pubmed.ncbi.nlm.nih.gov/14638870 DMRFTJX DI DMRFTJX DMRFTJX DN Daidzein DMRFTJX MI TT9ZRHB DMRFTJX MN Estrogen-related receptor-gamma (ESRRG) DMRFTJX MT DTT DMRFTJX MA Agonist DMRFTJX RN Flavone and isoflavone phytoestrogens are agonists of estrogen-related receptors. Mol Cancer Res. 2003 Nov;1(13):981-91. DMRFTJX RU https://pubmed.ncbi.nlm.nih.gov/14638870 DMRFTJX DI DMRFTJX DMRFTJX DN Daidzein DMRFTJX MI TT32NQ1 DMRFTJX MN Short transient receptor potential channel 5 (TRPC5) DMRFTJX MT DTT DMRFTJX MA Activator DMRFTJX RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 490). DMRFTJX RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=490 DMRFTJX DI DMRFTJX DMRFTJX DN Daidzein DMRFTJX MI DE0P6LK DMRFTJX MN Sulfotransferase 2A1 (SULT2A1) DMRFTJX MT DME DMRFTJX MA Metabolism DMRFTJX RN Sulfation of environmental estrogens by cytosolic human sulfotransferases. Drug Metab Pharmacokinet. 2002;17(3):221-8. DMRFTJX RU https://www.ncbi.nlm.nih.gov/pubmed/?term=15618673 DM3M652 DI DM3M652 DM3M652 DN Daio-Orengedokuto (DOT) DM3M652 MI TTXMY0J DM3M652 MN Pancreatic triacylglycerol lipase (PNLIP) DM3M652 MT DTT DM3M652 MA Inhibitor DM3M652 RN Daio-Orengedokuto inhibits HMG-CoA reductase and pancreatic lipase. Biol Pharm Bull. 2002 Nov;25(11):1442-5. DM3M652 RU https://pubmed.ncbi.nlm.nih.gov/12419956 DMVIDQL DI DMVIDQL DMVIDQL DN D-alanine DMVIDQL MI TTLP6GN DMVIDQL MN Bacterial DD-carboxypeptidase (Bact vanYB) DMVIDQL MT DTT DMVIDQL MA Inhibitor DMVIDQL RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMVIDQL RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMS1DVA DI DMS1DVA DMS1DVA DN DAMGO DMS1DVA MI TT27RFC DMS1DVA MN Opioid receptor delta (OPRD1) DMS1DVA MT DTT DMS1DVA MA Inhibitor DMS1DVA RN Evaluation of N-substitution in 6,7-benzomorphan compounds. Bioorg Med Chem. 2010 Jul 15;18(14):4975-82. DMS1DVA RU https://pubmed.ncbi.nlm.nih.gov/20599386 DMS1DVA DI DMS1DVA DMS1DVA DN DAMGO DMS1DVA MI TTQW87Y DMS1DVA MN Opioid receptor kappa (OPRK1) DMS1DVA MT DTT DMS1DVA MA Inhibitor DMS1DVA RN Opiate receptor binding properties of morphine-, dihydromorphine-, and codeine 6-O-sulfate ester congeners. Bioorg Med Chem Lett. 2006 Aug 15;16(16):4291-5. DMS1DVA RU https://pubmed.ncbi.nlm.nih.gov/16777416 DMS1DVA DI DMS1DVA DMS1DVA DN DAMGO DMS1DVA MI TTKWM86 DMS1DVA MN Opioid receptor mu (MOP) DMS1DVA MT DTT DMS1DVA MA Inhibitor DMS1DVA RN Evaluation of N-substitution in 6,7-benzomorphan compounds. Bioorg Med Chem. 2010 Jul 15;18(14):4975-82. DMS1DVA RU https://pubmed.ncbi.nlm.nih.gov/20599386 DMXM7JR DI DMXM7JR DMXM7JR DN daminozide DMXM7JR MI TT81PFE DMXM7JR MN Histone lysine demethylase PHF8 (PHF8) DMXM7JR MT DTT DMXM7JR MA Inhibitor DMXM7JR RN Plant growth regulator daminozide is a selective inhibitor of human KDM2/7 histone demethylases. J Med Chem. 2012 Jul 26;55(14):6639-43. DMXM7JR RU https://pubmed.ncbi.nlm.nih.gov/22724510 DMXM7JR DI DMXM7JR DMXM7JR DN daminozide DMXM7JR MI TT8XTY2 DMXM7JR MN Lysine-specific demethylase 2A (KDM2A) DMXM7JR MT DTT DMXM7JR MA Inhibitor DMXM7JR RN Plant growth regulator daminozide is a selective inhibitor of human KDM2/7 histone demethylases. J Med Chem. 2012 Jul 26;55(14):6639-43. DMXM7JR RU https://pubmed.ncbi.nlm.nih.gov/22724510 DMXM7JR DI DMXM7JR DMXM7JR DN daminozide DMXM7JR MI TT0NYMP DMXM7JR MN Lysine-specific demethylase 7A (KDM7A) DMXM7JR MT DTT DMXM7JR MA Inhibitor DMXM7JR RN Plant growth regulator daminozide is a selective inhibitor of human KDM2/7 histone demethylases. J Med Chem. 2012 Jul 26;55(14):6639-43. DMXM7JR RU https://pubmed.ncbi.nlm.nih.gov/22724510 DMQ4L1I DI DMQ4L1I DMQ4L1I DN Dansylamide DMQ4L1I MI TTANPDJ DMQ4L1I MN Carbonic anhydrase II (CA-II) DMQ4L1I MT DTT DMQ4L1I MA Inhibitor DMQ4L1I RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMQ4L1I RU https://pubmed.ncbi.nlm.nih.gov/17139284 DM2WS8B DI DM2WS8B DM2WS8B DN D-AP4 DM2WS8B MI TT0IFKL DM2WS8B MN Metabotropic glutamate receptor 8 (mGluR8) DM2WS8B MT DTT DM2WS8B MA Agonist DM2WS8B RN Group III human metabotropic glutamate receptors 4, 7 and 8: molecular cloning, functional expression, and comparison of pharmacological properties in RGT cells. Brain Res Mol Brain Res. 1998 Jan;53(1-2):88-97. DM2WS8B RU https://pubmed.ncbi.nlm.nih.gov/9473604 DMY5OTN DI DMY5OTN DMY5OTN DN d-AP5 DMY5OTN MI TTKJEMQ DMY5OTN MN Glutamate receptor ionotropic NMDA 2A (NMDAR2A) DMY5OTN MT DTT DMY5OTN MA Antagonist DMY5OTN RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 456). DMY5OTN RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=456 DMY5OTN DI DMY5OTN DMY5OTN DN d-AP5 DMY5OTN MI TTN9D8E DMY5OTN MN Glutamate receptor ionotropic NMDA 2B (NMDAR2B) DMY5OTN MT DTT DMY5OTN MA Antagonist DMY5OTN RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 457). DMY5OTN RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=457 DMY5OTN DI DMY5OTN DMY5OTN DN d-AP5 DMY5OTN MI TT1M8OW DMY5OTN MN Glutamate receptor ionotropic NMDA 2C (GluN2C) DMY5OTN MT DTT DMY5OTN MA Antagonist DMY5OTN RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 458). DMY5OTN RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=458 DMY5OTN DI DMY5OTN DMY5OTN DN d-AP5 DMY5OTN MI TT5POTG DMY5OTN MN Glutamate receptor ionotropic NMDA 2D (GluN2D) DMY5OTN MT DTT DMY5OTN MA Antagonist DMY5OTN RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 459). DMY5OTN RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=459 DMZ4Q0B DI DMZ4Q0B DMZ4Q0B DN Dasatinib DMZ4Q0B MI TTE63HY DMZ4Q0B MN HUMAN fusion protein Bcr-Abl (Bcr-Abl) DMZ4Q0B MT DTT DMZ4Q0B MA Inhibitor DMZ4Q0B RN Coronaviruses - drug discovery and therapeutic options. Nat Rev Drug Discov. 2016 May;15(5):327-47. DMZ4Q0B RU https://pubmed.ncbi.nlm.nih.gov/26868298 DM7Z892 DI DM7Z892 DM7Z892 DN D-aspartic acid DM7Z892 MI TT8WRDA DM7Z892 MN Excitatory amino acid transporter 1 (SLC1A3) DM7Z892 MT DTT DM7Z892 MA Modulator DM7Z892 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 868). DM7Z892 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=868 DM7Z892 DI DM7Z892 DM7Z892 DN D-aspartic acid DM7Z892 MI TT2F078 DM7Z892 MN Excitatory amino acid transporter 2 (SLC1A2) DM7Z892 MT DTT DM7Z892 MA Modulator DM7Z892 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 869). DM7Z892 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=869 DM7Z892 DI DM7Z892 DM7Z892 DN D-aspartic acid DM7Z892 MI TTG2A6F DM7Z892 MN Excitatory amino acid transporter 3 (SLC1A1) DM7Z892 MT DTT DM7Z892 MA Modulator DM7Z892 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 870). DM7Z892 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=870 DM7Z892 DI DM7Z892 DM7Z892 DN D-aspartic acid DM7Z892 MI TT6KMPN DM7Z892 MN Excitatory amino acid transporter 4 (SLC1A6) DM7Z892 MT DTT DM7Z892 MA Modulator DM7Z892 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 871). DM7Z892 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=871 DM7Z892 DI DM7Z892 DM7Z892 DN D-aspartic acid DM7Z892 MI TTK41DM DM7Z892 MN Excitatory amino acid transporter 5 (SLC1A7) DM7Z892 MT DTT DM7Z892 MA Modulator DM7Z892 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 872). DM7Z892 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=872 DM7Z892 DI DM7Z892 DM7Z892 DN D-aspartic acid DM7Z892 MI TTLD29N DM7Z892 MN Glutamate receptor ionotropic NMDA 1 (NMDAR1) DM7Z892 MT DTT DM7Z892 MA Agonist DM7Z892 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 455). DM7Z892 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=455 DM7Z892 DI DM7Z892 DM7Z892 DN D-aspartic acid DM7Z892 MI TTKJEMQ DM7Z892 MN Glutamate receptor ionotropic NMDA 2A (NMDAR2A) DM7Z892 MT DTT DM7Z892 MA Agonist DM7Z892 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 456). DM7Z892 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=456 DM7Z892 DI DM7Z892 DM7Z892 DN D-aspartic acid DM7Z892 MI TTN9D8E DM7Z892 MN Glutamate receptor ionotropic NMDA 2B (NMDAR2B) DM7Z892 MT DTT DM7Z892 MA Agonist DM7Z892 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 457). DM7Z892 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=457 DM7Z892 DI DM7Z892 DM7Z892 DN D-aspartic acid DM7Z892 MI TT1M8OW DM7Z892 MN Glutamate receptor ionotropic NMDA 2C (GluN2C) DM7Z892 MT DTT DM7Z892 MA Agonist DM7Z892 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 458). DM7Z892 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=458 DM7Z892 DI DM7Z892 DM7Z892 DN D-aspartic acid DM7Z892 MI TT5POTG DM7Z892 MN Glutamate receptor ionotropic NMDA 2D (GluN2D) DM7Z892 MT DTT DM7Z892 MA Agonist DM7Z892 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 459). DM7Z892 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=459 DMMXFBJ DI DMMXFBJ DMMXFBJ DN dATP DMMXFBJ MI TTYXPCO DMMXFBJ MN P2Y purinoceptor 11 (P2RY11) DMMXFBJ MT DTT DMMXFBJ MA Agonist DMMXFBJ RN Pharmacological characterization of the human P2Y11 receptor. Br J Pharmacol. 1999 Nov;128(6):1199-206. DMMXFBJ RU https://pubmed.ncbi.nlm.nih.gov/10578132 DMRDX8U DI DMRDX8U DMRDX8U DN dATPalphaS DMRDX8U MI TTA93TL DMRDX8U MN P2Y purinoceptor 1 (P2RY1) DMRDX8U MT DTT DMRDX8U MA Agonist DMRDX8U RN An examination of deoxyadenosine 5'(alpha-thio)triphosphate as a ligand to define P2Y receptors and its selectivity as a low potency partial agonist of the P2Y1 receptor. Br J Pharmacol. 1997 May;121(2):338-44. DMRDX8U RU https://pubmed.ncbi.nlm.nih.gov/9154346 DMT14A7 DI DMT14A7 DMT14A7 DN DAU-5750 DMT14A7 MI TTZ9SOR DMT14A7 MN Muscarinic acetylcholine receptor M1 (CHRM1) DMT14A7 MT DTT DMT14A7 MA Modulator DMT14A7 RN Synthesis, absolute configuration, conformational analysis and binding affinity properties of enantiomeric forms of DAU 5750, a novel M1-M3 muscari... Bioorg Med Chem. 1994 Dec;2(12):1375-83. DMT14A7 RU https://www.ncbi.nlm.nih.gov/pubmed/7788300 DMT14A7 DI DMT14A7 DMT14A7 DN DAU-5750 DMT14A7 MI TTQ13Z5 DMT14A7 MN Muscarinic acetylcholine receptor M3 (CHRM3) DMT14A7 MT DTT DMT14A7 MA Modulator DMT14A7 RN Synthesis, absolute configuration, conformational analysis and binding affinity properties of enantiomeric forms of DAU 5750, a novel M1-M3 muscari... Bioorg Med Chem. 1994 Dec;2(12):1375-83. DMT14A7 RU https://www.ncbi.nlm.nih.gov/pubmed/7788300 DMEZVGK DI DMEZVGK DMEZVGK DN DAU-5884 DMEZVGK MI TTZ9SOR DMEZVGK MN Muscarinic acetylcholine receptor M1 (CHRM1) DMEZVGK MT DTT DMEZVGK MA Modulator DMEZVGK RN Doi: 10.1038/bjp.2008.208 DMEZVGK RU http://onlinelibrary.wiley.com/doi/10.1038/bjp.2008.208/pdf DMEZVGK DI DMEZVGK DMEZVGK DN DAU-5884 DMEZVGK MI TTQ13Z5 DMEZVGK MN Muscarinic acetylcholine receptor M3 (CHRM3) DMEZVGK MT DTT DMEZVGK MA Modulator DMEZVGK RN Doi: 10.1038/bjp.2008.208 DMEZVGK RU http://onlinelibrary.wiley.com/doi/10.1038/bjp.2008.208/pdf DMM5SI1 DI DMM5SI1 DMM5SI1 DN DAU-6202 DMM5SI1 MI TTZ9SOR DMM5SI1 MN Muscarinic acetylcholine receptor M1 (CHRM1) DMM5SI1 MT DTT DMM5SI1 MA Modulator DMM5SI1 RN Characterization of muscarinic receptors in guinea-pig uterus. Eur J Pharmacol. 1993 Dec 7;250(2):223-30. DMM5SI1 RU https://www.ncbi.nlm.nih.gov/pubmed/8112383 DMEST0R DI DMEST0R DMEST0R DN DB-160 DMEST0R MI TTDIGC1 DMEST0R MN Dipeptidyl peptidase 4 (DPP-4) DMEST0R MT DTT DMEST0R MA Inhibitor DMEST0R RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1612). DMEST0R RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1612 DMGRUN1 DI DMGRUN1 DMGRUN1 DN DB-900 DMGRUN1 MI TTJ584C DMGRUN1 MN Peroxisome proliferator-activated receptor alpha (PPARA) DMGRUN1 MT DTT DMGRUN1 MA Agonist DMGRUN1 RN CN patent application no. 102459215, 3-(4-aminophenyl)-2-furancarboxylic acid derivative and pharmaceutically acceptable salt thereof. DMGRUN1 RU http://www.google.com/patents/CN102459215A?cl=en DMGRUN1 DI DMGRUN1 DMGRUN1 DN DB-900 DMGRUN1 MI TT2JWF6 DMGRUN1 MN Peroxisome proliferator-activated receptor delta (PPARD) DMGRUN1 MT DTT DMGRUN1 MA Agonist DMGRUN1 RN CN patent application no. 102459215, 3-(4-aminophenyl)-2-furancarboxylic acid derivative and pharmaceutically acceptable salt thereof. DMGRUN1 RU http://www.google.com/patents/CN102459215A?cl=en DMGRUN1 DI DMGRUN1 DMGRUN1 DN DB-900 DMGRUN1 MI TTZMAO3 DMGRUN1 MN Peroxisome proliferator-activated receptor gamma (PPAR-gamma) DMGRUN1 MT DTT DMGRUN1 MA Agonist DMGRUN1 RN CN patent application no. 102459215, 3-(4-aminophenyl)-2-furancarboxylic acid derivative and pharmaceutically acceptable salt thereof. DMGRUN1 RU http://www.google.com/patents/CN102459215A?cl=en DMFYCQ1 DI DMFYCQ1 DMFYCQ1 DN DBT-066 DMFYCQ1 MI TTMO9HF DMFYCQ1 MN Advanced glycosylation end product receptor (AGER) DMFYCQ1 MT DTT DMFYCQ1 MA Modulator DMFYCQ1 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2843). DMFYCQ1 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2843 DM09YI7 DI DM09YI7 DM09YI7 DN DBT-1339 DM09YI7 MI TTE4KHA DM09YI7 MN Amyloid beta A4 protein (APP) DM09YI7 MT DTT DM09YI7 MA Inhibitor DM09YI7 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2402). DM09YI7 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2402 DMX9FOB DI DMX9FOB DMX9FOB DN DC6S DMX9FOB MI TTKWM86 DMX9FOB MN Opioid receptor mu (MOP) DMX9FOB MT DTT DMX9FOB MA Inhibitor DMX9FOB RN Opiate receptor binding properties of morphine-, dihydromorphine-, and codeine 6-O-sulfate ester congeners. Bioorg Med Chem Lett. 2006 Aug 15;16(16):4291-5. DMX9FOB RU https://pubmed.ncbi.nlm.nih.gov/16777416 DM62IBX DI DM62IBX DM62IBX DN DC-9703 DM62IBX MI TTCBFJO DM62IBX MN Insulin receptor (INSR) DM62IBX MT DTT DM62IBX MA Modulator DM62IBX RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1800). DM62IBX RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1800 DMHNAJ7 DI DMHNAJ7 DMHNAJ7 DN D-carnitine DMHNAJ7 MI DT3HUVD DMHNAJ7 MN Organic cation/carnitine transporter 2 (SLC22A5) DMHNAJ7 MT DTP DMHNAJ7 MA Substrate DMHNAJ7 RN Functional and pharmacological characterization of human Na(+)-carnitine cotransporter hOCTN2. Am J Physiol Renal Physiol. 2000 Sep;279(3):F584-91. DMHNAJ7 RU http://www.ncbi.nlm.nih.gov/pubmed/10966938 DMPRYTW DI DMPRYTW DMPRYTW DN DCB-3503 DMPRYTW MI TTS7IR5 DMPRYTW MN c-Jun messenger RNA (c-Jun mRNA) DMPRYTW MT DTT DMPRYTW MA Inhibitor DMPRYTW RN Structure-activity studies of phenanthroindolizidine alkaloids as potential antitumor agents. Bioorg Med Chem Lett. 2007 Aug 1;17(15):4338-42. DMPRYTW RU https://pubmed.ncbi.nlm.nih.gov/17531481 DM36D0F DI DM36D0F DM36D0F DN d-CCPene DM36D0F MI TTKJEMQ DM36D0F MN Glutamate receptor ionotropic NMDA 2A (NMDAR2A) DM36D0F MT DTT DM36D0F MA Antagonist DM36D0F RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 456). DM36D0F RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=456 DM36D0F DI DM36D0F DM36D0F DN d-CCPene DM36D0F MI TTN9D8E DM36D0F MN Glutamate receptor ionotropic NMDA 2B (NMDAR2B) DM36D0F MT DTT DM36D0F MA Antagonist DM36D0F RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 457). DM36D0F RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=457 DM36D0F DI DM36D0F DM36D0F DN d-CCPene DM36D0F MI TT1M8OW DM36D0F MN Glutamate receptor ionotropic NMDA 2C (GluN2C) DM36D0F MT DTT DM36D0F MA Antagonist DM36D0F RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 458). DM36D0F RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=458 DM36D0F DI DM36D0F DM36D0F DN d-CCPene DM36D0F MI TT5POTG DM36D0F MN Glutamate receptor ionotropic NMDA 2D (GluN2D) DM36D0F MT DTT DM36D0F MA Antagonist DM36D0F RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 459). DM36D0F RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=459 DMG9BFR DI DMG9BFR DMG9BFR DN DCDPC DMG9BFR MI TTOJI4S DMG9BFR MN Calcium-dependent chloride channel anoctamin (ANO) DMG9BFR MT DTT DMG9BFR MA Blocker (channel blocker) DMG9BFR RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 708). DMG9BFR RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=708 DM2T5OV DI DM2T5OV DM2T5OV DN DC-EBIO DM2T5OV MI TT2T5M0 DM2T5OV MN Calcium-activated potassium channel KCa2.2 (KCNN2) DM2T5OV MT DTT DM2T5OV MA Activator DM2T5OV RN Specific enhancement of SK channel activity selectively potentiates the afterhyperpolarizing current I(AHP) and modulates the firing properties of ... J Biol Chem. 2005 Dec 16;280(50):41404-11. DM2T5OV RU https://pubmed.ncbi.nlm.nih.gov/16239218 DM2T5OV DI DM2T5OV DM2T5OV DN DC-EBIO DM2T5OV MI TT9JH25 DM2T5OV MN Calcium-activated potassium channel KCa2.3 (KCNN3) DM2T5OV MT DTT DM2T5OV MA Activator DM2T5OV RN Modulators of small- and intermediate-conductance calcium-activated potassium channels and their therapeutic indications. Curr Med Chem. 2007;14(13):1437-57. DM2T5OV RU https://pubmed.ncbi.nlm.nih.gov/17584055 DM2T5OV DI DM2T5OV DM2T5OV DN DC-EBIO DM2T5OV MI TT7M9I6 DM2T5OV MN Calcium-activated potassium channel KCa3.1 (KCNN4) DM2T5OV MT DTT DM2T5OV MA Activator DM2T5OV RN Benzimidazolone activators of chloride secretion: potential therapeutics for cystic fibrosis and chronic obstructive pulmonary disease. J Pharmacol Exp Ther. 2001 Feb;296(2):600-11. DM2T5OV RU https://pubmed.ncbi.nlm.nih.gov/11160649 DM9HG1Y DI DM9HG1Y DM9HG1Y DN DCG IV DM9HG1Y MI TTXJ47W DM9HG1Y MN Metabotropic glutamate receptor 2 (mGluR2) DM9HG1Y MT DTT DM9HG1Y MA Agonist DM9HG1Y RN Attenuation of seizures induced by homocysteic acid in immature rats by metabotropic glutamate group II and group III receptor agonists. Brain Res. 2001 Jul 27;908(2):120-9. DM9HG1Y RU https://pubmed.ncbi.nlm.nih.gov/11454322 DMU287Q DI DMU287Q DMU287Q DN Dcp-c[D-Cys-Gly-Phe(pNO2)-D-Cys]NH2 DMU287Q MI TT27RFC DMU287Q MN Opioid receptor delta (OPRD1) DMU287Q MT DTT DMU287Q MA Inhibitor DMU287Q RN Replacement of the N-terminal tyrosine residue in opioid peptides with 3-(2,6-dimethyl-4-carbamoylphenyl)propanoic acid (Dcp) results in novel opio... J Med Chem. 2006 Aug 24;49(17):5382-5. DMU287Q RU https://pubmed.ncbi.nlm.nih.gov/16913729 DMU287Q DI DMU287Q DMU287Q DN Dcp-c[D-Cys-Gly-Phe(pNO2)-D-Cys]NH2 DMU287Q MI TTQW87Y DMU287Q MN Opioid receptor kappa (OPRK1) DMU287Q MT DTT DMU287Q MA Inhibitor DMU287Q RN Replacement of the N-terminal tyrosine residue in opioid peptides with 3-(2,6-dimethyl-4-carbamoylphenyl)propanoic acid (Dcp) results in novel opio... J Med Chem. 2006 Aug 24;49(17):5382-5. DMU287Q RU https://pubmed.ncbi.nlm.nih.gov/16913729 DMU287Q DI DMU287Q DMU287Q DN Dcp-c[D-Cys-Gly-Phe(pNO2)-D-Cys]NH2 DMU287Q MI TTKWM86 DMU287Q MN Opioid receptor mu (MOP) DMU287Q MT DTT DMU287Q MA Inhibitor DMU287Q RN Replacement of the N-terminal tyrosine residue in opioid peptides with 3-(2,6-dimethyl-4-carbamoylphenyl)propanoic acid (Dcp) results in novel opio... J Med Chem. 2006 Aug 24;49(17):5382-5. DMU287Q RU https://pubmed.ncbi.nlm.nih.gov/16913729 DM9NMIY DI DM9NMIY DM9NMIY DN DCPIB DM9NMIY MI TT0FC1V DM9NMIY MN Volume regulated chloride channel (VRAC) DM9NMIY MT DTT DM9NMIY MA Blocker (channel blocker) DM9NMIY RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 710). DM9NMIY RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=710 DMV0JQG DI DMV0JQG DMV0JQG DN DD7 DMV0JQG MI TTPLTSQ DMV0JQG MN Neutrophil elastase (NE) DMV0JQG MT DTT DMV0JQG RN Therapeutic applications of aptamers. Expert Opin Investig Drugs. 2008 Jan;17(1):43-60. DMV0JQG RU https://pubmed.ncbi.nlm.nih.gov/18095918 DM6GWAC DI DM6GWAC DM6GWAC DN DDATHF DM6GWAC MI TTCSJBZ DM6GWAC MN GAR transformylase (GART) DM6GWAC MT DTT DM6GWAC MA Modulator DM6GWAC RN Rational design, synthesis, evaluation, and crystal structure of a potent inhibitor of human GAR Tfase: 10-(trifluoroacetyl)-5,10-dideazaacyclic-5,... Biochemistry. 2003 May 27;42(20):6043-56. DM6GWAC RU https://www.ncbi.nlm.nih.gov/pubmed/12755606 DM6GWAC DI DM6GWAC DM6GWAC DN DDATHF DM6GWAC MI TT9SL3Q DM6GWAC MN Polypeptide deformylase (PDF) DM6GWAC MT DTT DM6GWAC MA Inhibitor DM6GWAC RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DM6GWAC RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMHLNA2 DI DMHLNA2 DMHLNA2 DN DdCTP SODIUM DMHLNA2 MI TTIU7X1 DMHLNA2 MN Herpes simplex virus DNA polymerase UL30 (HSV UL30) DMHLNA2 MT DTT DMHLNA2 MA Inhibitor DMHLNA2 RN Acylphloroglucinol derivatives from Mahurea palustris. J Nat Prod. 2005 Jul;68(7):979-84. DMHLNA2 RU https://pubmed.ncbi.nlm.nih.gov/16038535 DMDFRTI DI DMDFRTI DMDFRTI DN Deamido-NAD DMDFRTI MI TT1NFO3 DMDFRTI MN Bacterial Nicotinate-nucleotide adenylyltransferase (Bact nadD) DMDFRTI MT DTT DMDFRTI MA Binder DMDFRTI RN Crystal structures of E. coli nicotinate mononucleotide adenylyltransferase and its complex with deamido-NAD. Structure. 2002 Jan;10(1):69-79. DMDFRTI RU https://pubmed.ncbi.nlm.nih.gov/11796112 DMFTNAP DI DMFTNAP DMFTNAP DN Debio-0930 DMFTNAP MI TTLAFZV DMFTNAP MN AMP-activated protein kinase (AMPK) DMFTNAP MT DTT DMFTNAP MA Stimulator DMFTNAP RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1540). DMFTNAP RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1540 DMDLER8 DI DMDLER8 DMDLER8 DN DEBROMOHYMENIALDISINE DMDLER8 MI TTTU902 DMDLER8 MN Checkpoint kinase-1 (CHK1) DMDLER8 MT DTT DMDLER8 MA Inhibitor DMDLER8 RN Potent inhibition of checkpoint kinase activity by a hymenialdisine-derived indoloazepine. Bioorg Med Chem Lett. 2004 Aug 16;14(16):4319-21. DMDLER8 RU https://pubmed.ncbi.nlm.nih.gov/15261294 DMDLER8 DI DMDLER8 DMDLER8 DN DEBROMOHYMENIALDISINE DMDLER8 MI TTIDAPM DMDLER8 MN ERK activator kinase 1 (MEK1) DMDLER8 MT DTT DMDLER8 MA Inhibitor DMDLER8 RN Aldisine alkaloids from the Philippine sponge Stylissa massa are potent inhibitors of mitogen-activated protein kinase kinase-1 (MEK-1). J Med Chem. 2002 Jan 17;45(2):529-32. DMDLER8 RU https://pubmed.ncbi.nlm.nih.gov/11784156 DMDLER8 DI DMDLER8 DMDLER8 DN DEBROMOHYMENIALDISINE DMDLER8 MI TT4TQBX DMDLER8 MN Extracellular signal-regulated kinase 2 (ERK2) DMDLER8 MT DTT DMDLER8 MA Inhibitor DMDLER8 RN Potent inhibition of checkpoint kinase activity by a hymenialdisine-derived indoloazepine. Bioorg Med Chem Lett. 2004 Aug 16;14(16):4319-21. DMDLER8 RU https://pubmed.ncbi.nlm.nih.gov/15261294 DMDLER8 DI DMDLER8 DMDLER8 DN DEBROMOHYMENIALDISINE DMDLER8 MI TTAN5W2 DMDLER8 MN Raf messenger RNA (Raf mRNA) DMDLER8 MT DTT DMDLER8 MA Inhibitor DMDLER8 RN Aldisine alkaloids from the Philippine sponge Stylissa massa are potent inhibitors of mitogen-activated protein kinase kinase-1 (MEK-1). J Med Chem. 2002 Jan 17;45(2):529-32. DMDLER8 RU https://pubmed.ncbi.nlm.nih.gov/11784156 DMDLER8 DI DMDLER8 DMDLER8 DN DEBROMOHYMENIALDISINE DMDLER8 MI TT9ABMF DMDLER8 MN Serine/threonine-protein kinase Chk2 (RAD53) DMDLER8 MT DTT DMDLER8 MA Inhibitor DMDLER8 RN Potent inhibition of checkpoint kinase activity by a hymenialdisine-derived indoloazepine. Bioorg Med Chem Lett. 2004 Aug 16;14(16):4319-21. DMDLER8 RU https://pubmed.ncbi.nlm.nih.gov/15261294 DMWZKLM DI DMWZKLM DMWZKLM DN Decanal DMWZKLM MI DE2JP1Y DMWZKLM MN Aldehyde dehydrogenase 1 (ALDH1) DMWZKLM MT DME DMWZKLM MA Metabolism DMWZKLM RN Retinoic acid biosynthesis catalyzed by retinal dehydrogenases relies on a rate-limiting conformational transition associated with substrate recognition. Chem Biol Interact. 2013 Feb 25;202(1-3):78-84. DMWZKLM RU https://www.ncbi.nlm.nih.gov/pubmed/?term=23220587 DM1ESVR DI DM1ESVR DM1ESVR DN Decane-1,10-diyl disulfamate DM1ESVR MI TTUNARX DM1ESVR MN Carbonic anhydrase (CA) DM1ESVR MT DTT DM1ESVR MA Inhibitor DM1ESVR RN Carbonic anhydrase inhibitors. Comparison of aliphatic sulfamate/bis-sulfamate adducts with isozymes II and IX as a platform for designing tight-bi... J Med Chem. 2009 Oct 8;52(19):5990-8. DM1ESVR RU https://pubmed.ncbi.nlm.nih.gov/19731956 DM1ESVR DI DM1ESVR DM1ESVR DN Decane-1,10-diyl disulfamate DM1ESVR MI TTHQPL7 DM1ESVR MN Carbonic anhydrase I (CA-I) DM1ESVR MT DTT DM1ESVR MA Inhibitor DM1ESVR RN Carbonic anhydrase inhibitors. Comparison of aliphatic sulfamate/bis-sulfamate adducts with isozymes II and IX as a platform for designing tight-bi... J Med Chem. 2009 Oct 8;52(19):5990-8. DM1ESVR RU https://pubmed.ncbi.nlm.nih.gov/19731956 DM1ESVR DI DM1ESVR DM1ESVR DN Decane-1,10-diyl disulfamate DM1ESVR MI TTANPDJ DM1ESVR MN Carbonic anhydrase II (CA-II) DM1ESVR MT DTT DM1ESVR MA Inhibitor DM1ESVR RN Carbonic anhydrase inhibitors. Comparison of aliphatic sulfamate/bis-sulfamate adducts with isozymes II and IX as a platform for designing tight-bi... J Med Chem. 2009 Oct 8;52(19):5990-8. DM1ESVR RU https://pubmed.ncbi.nlm.nih.gov/19731956 DM1ESVR DI DM1ESVR DM1ESVR DN Decane-1,10-diyl disulfamate DM1ESVR MI TTZHA0O DM1ESVR MN Carbonic anhydrase IV (CA-IV) DM1ESVR MT DTT DM1ESVR MA Inhibitor DM1ESVR RN Carbonic anhydrase inhibitors. Comparison of aliphatic sulfamate/bis-sulfamate adducts with isozymes II and IX as a platform for designing tight-bi... J Med Chem. 2009 Oct 8;52(19):5990-8. DM1ESVR RU https://pubmed.ncbi.nlm.nih.gov/19731956 DM1ESVR DI DM1ESVR DM1ESVR DN Decane-1,10-diyl disulfamate DM1ESVR MI TT2LVK8 DM1ESVR MN Carbonic anhydrase IX (CA-IX) DM1ESVR MT DTT DM1ESVR MA Inhibitor DM1ESVR RN Carbonic anhydrase inhibitors. Comparison of aliphatic sulfamate/bis-sulfamate adducts with isozymes II and IX as a platform for designing tight-bi... J Med Chem. 2009 Oct 8;52(19):5990-8. DM1ESVR RU https://pubmed.ncbi.nlm.nih.gov/19731956 DM1ESVR DI DM1ESVR DM1ESVR DN Decane-1,10-diyl disulfamate DM1ESVR MI TTCFSPE DM1ESVR MN Carbonic anhydrase VI (CA-VI) DM1ESVR MT DTT DM1ESVR MA Inhibitor DM1ESVR RN Carbonic anhydrase inhibitors. Comparison of aliphatic sulfamate/bis-sulfamate adducts with isozymes II and IX as a platform for designing tight-bi... J Med Chem. 2009 Oct 8;52(19):5990-8. DM1ESVR RU https://pubmed.ncbi.nlm.nih.gov/19731956 DM1ESVR DI DM1ESVR DM1ESVR DN Decane-1,10-diyl disulfamate DM1ESVR MI TTSYM0R DM1ESVR MN Carbonic anhydrase XII (CA-XII) DM1ESVR MT DTT DM1ESVR MA Inhibitor DM1ESVR RN Carbonic anhydrase inhibitors. Comparison of aliphatic sulfamate/bis-sulfamate adducts with isozymes II and IX as a platform for designing tight-bi... J Med Chem. 2009 Oct 8;52(19):5990-8. DM1ESVR RU https://pubmed.ncbi.nlm.nih.gov/19731956 DM1ESVR DI DM1ESVR DM1ESVR DN Decane-1,10-diyl disulfamate DM1ESVR MI TTEYTKG DM1ESVR MN Carbonic anhydrase XIV (CA-XIV) DM1ESVR MT DTT DM1ESVR MA Inhibitor DM1ESVR RN Carbonic anhydrase inhibitors. Comparison of aliphatic sulfamate/bis-sulfamate adducts with isozymes II and IX as a platform for designing tight-bi... J Med Chem. 2009 Oct 8;52(19):5990-8. DM1ESVR RU https://pubmed.ncbi.nlm.nih.gov/19731956 DM8FMYL DI DM8FMYL DM8FMYL DN Decanoic Acid DM8FMYL MI TTPH97Y DM8FMYL MN Mycobacterium 3-oxoacyl-[acyl-carrier-protein] synthase 1 (MycB kasA) DM8FMYL MT DTT DM8FMYL MA Inhibitor DM8FMYL RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DM8FMYL RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMLT1N3 DI DMLT1N3 DMLT1N3 DN decavanadate DMLT1N3 MI TT5HWAT DMLT1N3 MN IP3 receptor isoform 1 (ITPR1) DMLT1N3 MT DTT DMLT1N3 MA Antagonist DMLT1N3 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 743). DMLT1N3 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=743 DMLT1N3 DI DMLT1N3 DMLT1N3 DN decavanadate DMLT1N3 MI TTK9OV3 DMLT1N3 MN IP3 receptor isoform 2 (IP3R2) DMLT1N3 MT DTT DMLT1N3 MA Antagonist DMLT1N3 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 744). DMLT1N3 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=744 DMLT1N3 DI DMLT1N3 DMLT1N3 DN decavanadate DMLT1N3 MI TTH1769 DMLT1N3 MN IP3 receptor isoform 3 (ITPR3) DMLT1N3 MT DTT DMLT1N3 MA Antagonist DMLT1N3 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 745). DMLT1N3 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=745 DMLT1N3 DI DMLT1N3 DMLT1N3 DN decavanadate DMLT1N3 MI TTJ2HKA DMLT1N3 MN Long transient receptor potential channel 4 (TRPM4) DMLT1N3 MT DTT DMLT1N3 MA Activator DMLT1N3 RN Decavanadate modulates gating of TRPM4 cation channels. J Physiol. 2004 Nov 1;560(Pt 3):753-65. DMLT1N3 RU https://pubmed.ncbi.nlm.nih.gov/15331675 DMLT1N3 DI DMLT1N3 DMLT1N3 DN decavanadate DMLT1N3 MI TT473XN DMLT1N3 MN P2X purinoceptor 7 (P2RX7) DMLT1N3 MT DTT DMLT1N3 MA Antagonist DMLT1N3 RN Decavanadate, a P2X receptor antagonist, and its use to study ligand interactions with P2X7 receptors. Eur J Pharmacol. 2006 Mar 18;534(1-3):19-29. DMLT1N3 RU https://pubmed.ncbi.nlm.nih.gov/16487507 DM4SWYX DI DM4SWYX DM4SWYX DN DECIDIUM DM4SWYX MI TT1RS9F DM4SWYX MN Acetylcholinesterase (AChE) DM4SWYX MT DTT DM4SWYX MA Inhibitor DM4SWYX RN Exploiting protein fluctuations at the active-site gorge of human cholinesterases: further optimization of the design strategy to develop extremely... J Med Chem. 2008 Jun 12;51(11):3154-70. DM4SWYX RU https://pubmed.ncbi.nlm.nih.gov/18479118 DMHO3N1 DI DMHO3N1 DMHO3N1 DN Decoyinine DMHO3N1 MI TTCFP0V DMHO3N1 MN Glutamine amidotransferase (GMPS) DMHO3N1 MT DTT DMHO3N1 MA Inhibitor DMHO3N1 RN High-level production from a baculovirus expression system and biochemical characterization of human GMP synthetase. Protein Expr Purif. 1995 Aug;6(4):487-95. DMHO3N1 RU https://pubmed.ncbi.nlm.nih.gov/8527935 DMNKDT5 DI DMNKDT5 DMNKDT5 DN decyl dihydrogen phosphate DMNKDT5 MI TTB7Y8I DMNKDT5 MN Lysophosphatidic acid receptor 2 (LPAR2) DMNKDT5 MT DTT DMNKDT5 MA Agonist DMNKDT5 RN Fatty alcohol phosphates are subtype-selective agonists and antagonists of lysophosphatidic acid receptors. Mol Pharmacol. 2003 May;63(5):1032-42. DMNKDT5 RU https://pubmed.ncbi.nlm.nih.gov/12695531 DMIERWO DI DMIERWO DMIERWO DN Decyl sulfamate DMIERWO MI TTUNARX DMIERWO MN Carbonic anhydrase (CA) DMIERWO MT DTT DMIERWO MA Inhibitor DMIERWO RN Carbonic anhydrase inhibitors. Comparison of aliphatic sulfamate/bis-sulfamate adducts with isozymes II and IX as a platform for designing tight-bi... J Med Chem. 2009 Oct 8;52(19):5990-8. DMIERWO RU https://pubmed.ncbi.nlm.nih.gov/19731956 DMIERWO DI DMIERWO DMIERWO DN Decyl sulfamate DMIERWO MI TTHQPL7 DMIERWO MN Carbonic anhydrase I (CA-I) DMIERWO MT DTT DMIERWO MA Inhibitor DMIERWO RN Carbonic anhydrase inhibitors. Comparison of aliphatic sulfamate/bis-sulfamate adducts with isozymes II and IX as a platform for designing tight-bi... J Med Chem. 2009 Oct 8;52(19):5990-8. DMIERWO RU https://pubmed.ncbi.nlm.nih.gov/19731956 DMIERWO DI DMIERWO DMIERWO DN Decyl sulfamate DMIERWO MI TTANPDJ DMIERWO MN Carbonic anhydrase II (CA-II) DMIERWO MT DTT DMIERWO MA Inhibitor DMIERWO RN Carbonic anhydrase inhibitors. Comparison of aliphatic sulfamate/bis-sulfamate adducts with isozymes II and IX as a platform for designing tight-bi... J Med Chem. 2009 Oct 8;52(19):5990-8. DMIERWO RU https://pubmed.ncbi.nlm.nih.gov/19731956 DMIERWO DI DMIERWO DMIERWO DN Decyl sulfamate DMIERWO MI TTZHA0O DMIERWO MN Carbonic anhydrase IV (CA-IV) DMIERWO MT DTT DMIERWO MA Inhibitor DMIERWO RN Carbonic anhydrase inhibitors. Comparison of aliphatic sulfamate/bis-sulfamate adducts with isozymes II and IX as a platform for designing tight-bi... J Med Chem. 2009 Oct 8;52(19):5990-8. DMIERWO RU https://pubmed.ncbi.nlm.nih.gov/19731956 DMIERWO DI DMIERWO DMIERWO DN Decyl sulfamate DMIERWO MI TT2LVK8 DMIERWO MN Carbonic anhydrase IX (CA-IX) DMIERWO MT DTT DMIERWO MA Inhibitor DMIERWO RN Carbonic anhydrase inhibitors. Comparison of aliphatic sulfamate/bis-sulfamate adducts with isozymes II and IX as a platform for designing tight-bi... J Med Chem. 2009 Oct 8;52(19):5990-8. DMIERWO RU https://pubmed.ncbi.nlm.nih.gov/19731956 DMIERWO DI DMIERWO DMIERWO DN Decyl sulfamate DMIERWO MI TTCFSPE DMIERWO MN Carbonic anhydrase VI (CA-VI) DMIERWO MT DTT DMIERWO MA Inhibitor DMIERWO RN Carbonic anhydrase inhibitors. Comparison of aliphatic sulfamate/bis-sulfamate adducts with isozymes II and IX as a platform for designing tight-bi... J Med Chem. 2009 Oct 8;52(19):5990-8. DMIERWO RU https://pubmed.ncbi.nlm.nih.gov/19731956 DMIERWO DI DMIERWO DMIERWO DN Decyl sulfamate DMIERWO MI TTSYM0R DMIERWO MN Carbonic anhydrase XII (CA-XII) DMIERWO MT DTT DMIERWO MA Inhibitor DMIERWO RN Carbonic anhydrase inhibitors. Comparison of aliphatic sulfamate/bis-sulfamate adducts with isozymes II and IX as a platform for designing tight-bi... J Med Chem. 2009 Oct 8;52(19):5990-8. DMIERWO RU https://pubmed.ncbi.nlm.nih.gov/19731956 DMIERWO DI DMIERWO DMIERWO DN Decyl sulfamate DMIERWO MI TTEYTKG DMIERWO MN Carbonic anhydrase XIV (CA-XIV) DMIERWO MT DTT DMIERWO MA Inhibitor DMIERWO RN Carbonic anhydrase inhibitors. Comparison of aliphatic sulfamate/bis-sulfamate adducts with isozymes II and IX as a platform for designing tight-bi... J Med Chem. 2009 Oct 8;52(19):5990-8. DMIERWO RU https://pubmed.ncbi.nlm.nih.gov/19731956 DMQMR3P DI DMQMR3P DMQMR3P DN DECYL(DIMETHYL)PHOSPHINE OXIDE DMQMR3P MI TT3WG5C DMQMR3P MN Monoamine oxidase type A (MAO-A) DMQMR3P MT DTT DMQMR3P MA Inhibitor DMQMR3P RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DMQMR3P RU https://pubmed.ncbi.nlm.nih.gov/10592235 DM2WEB9 DI DM2WEB9 DM2WEB9 DN Decylamine-N,N-Dimethyl-N-Oxide DM2WEB9 MI TT3PQ2Y DM2WEB9 MN Plasmodium Dihydroorotate dehydrogenase (Malaria DHOdehase) DM2WEB9 MT DTT DM2WEB9 MA Inhibitor DM2WEB9 RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DM2WEB9 RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMFT3J2 DI DMFT3J2 DMFT3J2 DN Decyl-phosphonic acid DMFT3J2 MI TTQ6S1K DMFT3J2 MN Lysophosphatidic acid receptor 1 (LPAR1) DMFT3J2 MT DTT DMFT3J2 MA Inhibitor DMFT3J2 RN Synthesis, structure-activity relationships, and biological evaluation of fatty alcohol phosphates as lysophosphatidic acid receptor ligands, activ... J Med Chem. 2005 Jul 28;48(15):4919-30. DMFT3J2 RU https://pubmed.ncbi.nlm.nih.gov/16033271 DM1ITJ5 DI DM1ITJ5 DM1ITJ5 DN Decyltrimethylammonium DM1ITJ5 MI TTT1MCF DM1ITJ5 MN Permeability pathway (NP pathway) DM1ITJ5 MT DTT DM1ITJ5 MA Inhibitor DM1ITJ5 RN Novel molecular targets for antimalarial drug development. Chem Biol Drug Des. 2008 Apr;71(4):287-97. DM1ITJ5 RU https://pubmed.ncbi.nlm.nih.gov/18298458 DMWCTZ7 DI DMWCTZ7 DMWCTZ7 DN Decynium 22 DMWCTZ7 MI TTJLP0R DMWCTZ7 MN Quinone reductase 2 (NQO2) DMWCTZ7 MT DTT DMWCTZ7 MA Inhibitor DMWCTZ7 RN In silico identification and biochemical evaluation of novel inhibitors of NRH:quinone oxidoreductase 2 (NQO2). Bioorg Med Chem Lett. 2010 Dec 15;20(24):7331-6. DMWCTZ7 RU https://pubmed.ncbi.nlm.nih.gov/21074425 DMWCTZ7 DI DMWCTZ7 DMWCTZ7 DN Decynium 22 DMWCTZ7 MI TTTR957 DMWCTZ7 MN Solute carrier family 29 member 4 (SLC29A4) DMWCTZ7 MT DTT DMWCTZ7 MA Inhibitor DMWCTZ7 RN Interaction of organic cations with a newly identified plasma membrane monoamine transporter. Mol Pharmacol. 2005 Nov;68(5):1397-407. DMWCTZ7 RU https://pubmed.ncbi.nlm.nih.gov/16099839 DMKRT20 DI DMKRT20 DMKRT20 DN Degraded Cephaloridine DMKRT20 MI TTHI19T DMKRT20 MN Staphylococcus Beta-lactamase (Stap-coc blaZ) DMKRT20 MT DTT DMKRT20 MA Inhibitor DMKRT20 RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMKRT20 RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMXT7WG DI DMXT7WG DMXT7WG DN Deguelin DMXT7WG MI TT5LS6T DMXT7WG MN Aurora kinase B (AURKB) DMXT7WG MT DTT DMXT7WG MA Inhibitor DMXT7WG RN An Electrophilic Deguelin Analogue Inhibits STAT3 Signaling in H- Ras-Transformed Human Mammary Epithelial Cells: The Cysteine 259 Residue as a Potential Target. Biomedicines. 2020 Oct 12;8(10):407. DMXT7WG RU https://pubmed.ncbi.nlm.nih.gov/33053804 DMKYQO4 DI DMKYQO4 DMKYQO4 DN Dehydroascorbic acid DMKYQO4 MI DTG3T6X DMKYQO4 MN Glucose transporter type 1, erythrocyte/brain (SLC2A1) DMKYQO4 MT DTP DMKYQO4 MA Substrate DMKYQO4 RN Glucose transporter isoforms GLUT1 and GLUT3 transport dehydroascorbic acid. J Biol Chem. 1997 Jul 25;272(30):18982-9. DMKYQO4 RU http://www.ncbi.nlm.nih.gov/pubmed/9228080 DMKYQO4 DI DMKYQO4 DMKYQO4 DN Dehydroascorbic acid DMKYQO4 MI DT18YD9 DMKYQO4 MN Glucose transporter type 14 (SLC2A14) DMKYQO4 MT DTP DMKYQO4 MA Substrate DMKYQO4 RN The SLC2A14 gene, encoding the novel glucose/dehydroascorbate transporter GLUT14, is associated with inflammatory bowel disease. Am J Clin Nutr. 2017 Dec;106(6):1508-1513. DMKYQO4 RU http://www.ncbi.nlm.nih.gov/pubmed/28971850 DMKYQO4 DI DMKYQO4 DMKYQO4 DN Dehydroascorbic acid DMKYQO4 MI DEZSNJD DMKYQO4 MN Glutathione S-transferase omega-1 (GSTO1) DMKYQO4 MT DME DMKYQO4 MA Metabolism DMKYQO4 RN Structural insights into the dehydroascorbate reductase activity of human omega-class glutathione transferases. J Mol Biol. 2012 Jul 13;420(3):190-203. DMKYQO4 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=22522127 DMKYQO4 DI DMKYQO4 DMKYQO4 DN Dehydroascorbic acid DMKYQO4 MI DEHMPZR DMKYQO4 MN Glutathione S-transferase omega-2 (GSTO2) DMKYQO4 MT DME DMKYQO4 MA Metabolism DMKYQO4 RN Structural insights into the dehydroascorbate reductase activity of human omega-class glutathione transferases. J Mol Biol. 2012 Jul 13;420(3):190-203. DMKYQO4 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=22522127 DMCDLH2 DI DMCDLH2 DMCDLH2 DN Dehydrocholic acid DMCDLH2 MI DEOMLHG DMCDLH2 MN Beta-hydroxysteroid dehydrogenase (hdhB) DMCDLH2 MT DME DMCDLH2 MA Metabolism DMCDLH2 RN Identification, cloning, heterologous expression, and characterization of a NADPH-dependent 7beta-hydroxysteroid dehydrogenase from Collinsella aerofaciens. Appl Microbiol Biotechnol. 2011 Apr;90(1):127-35. DMCDLH2 RU https://pubmed.ncbi.nlm.nih.gov/21181147 DM48KMB DI DM48KMB DM48KMB DN Dehydrocorticosterone DM48KMB MI DEZDRQO DM48KMB MN Corticosteroid 11-beta-dehydrogenase 1 (HSD11B1) DM48KMB MT DME DM48KMB MA Metabolism DM48KMB RN Comparative enzymology of 11beta-hydroxysteroid dehydrogenase type 1 from six species. J Mol Endocrinol. 2005 Aug;35(1):89-101. DM48KMB RU https://www.ncbi.nlm.nih.gov/pubmed/?term=16087724 DM48KMB DI DM48KMB DM48KMB DN Dehydrocorticosterone DM48KMB MI DEDH7FP DM48KMB MN Corticosteroid 11-beta-dehydrogenase 2 (HSD11B2) DM48KMB MT DME DM48KMB MA Metabolism DM48KMB RN Comparative enzymology of 11beta-hydroxysteroid dehydrogenase type 1 from six species. J Mol Endocrinol. 2005 Aug;35(1):89-101. DM48KMB RU https://www.ncbi.nlm.nih.gov/pubmed/?term=16087724 DM0V1NH DI DM0V1NH DM0V1NH DN DEHYDROLEUCODIN DM0V1NH MI TTSZLWK DM0V1NH MN Aromatase (CYP19A1) DM0V1NH MT DTT DM0V1NH MA Inhibitor DM0V1NH RN Pharmacophore modeling strategies for the development of novel nonsteroidal inhibitors of human aromatase (CYP19). Bioorg Med Chem Lett. 2010 May 15;20(10):3050-64. DM0V1NH RU https://pubmed.ncbi.nlm.nih.gov/20413308 DMIOA9M DI DMIOA9M DMIOA9M DN Dehydropipernonaline DMIOA9M MI TTA1L39 DMIOA9M MN ICAM1 messenger RNA (ICAM1 mRNA) DMIOA9M MT DTT DMIOA9M MA Inhibitor DMIOA9M RN Alkamides from the fruits of Piper longum and Piper nigrum displaying potent cell adhesion inhibition. Bioorg Med Chem Lett. 2008 Aug 15;18(16):4544-6. DMIOA9M RU https://pubmed.ncbi.nlm.nih.gov/18672369 DM9TWR7 DI DM9TWR7 DM9TWR7 DN DEHYDROZINGERONE DM9TWR7 MI TTE4KHA DM9TWR7 MN Amyloid beta A4 protein (APP) DM9TWR7 MT DTT DM9TWR7 MA Inhibitor DM9TWR7 RN Curcumin and dehydrozingerone derivatives: synthesis, radiolabeling, and evaluation for beta-amyloid plaque imaging. J Med Chem. 2006 Oct 5;49(20):6111-9. DM9TWR7 RU https://pubmed.ncbi.nlm.nih.gov/17004725 DMGZ2H5 DI DMGZ2H5 DMGZ2H5 DN Del 60 tetramer DMGZ2H5 MI TTI2S1D DMGZ2H5 MN Cytotoxic T-lymphocyte protein 4 (CTLA-4) DMGZ2H5 MT DTT DMGZ2H5 RN Therapeutic applications of aptamers. Expert Opin Investig Drugs. 2008 Jan;17(1):43-60. DMGZ2H5 RU https://pubmed.ncbi.nlm.nih.gov/18095918 DM5ARHI DI DM5ARHI DM5ARHI DN DELTA 8-TETRAHYDROCANNOBINOL DM5ARHI MI TT6OEDT DM5ARHI MN Cannabinoid receptor 1 (CB1) DM5ARHI MT DTT DM5ARHI MA Inhibitor DM5ARHI RN Bornyl- and isobornyl-Delta8-tetrahydrocannabinols: a novel class of cannabinergic ligands. J Med Chem. 2008 Oct 23;51(20):6393-9. DM5ARHI RU https://pubmed.ncbi.nlm.nih.gov/18826296 DM5ARHI DI DM5ARHI DM5ARHI DN DELTA 8-TETRAHYDROCANNOBINOL DM5ARHI MI TTMSFAW DM5ARHI MN Cannabinoid receptor 2 (CB2) DM5ARHI MT DTT DM5ARHI MA Inhibitor DM5ARHI RN Bornyl- and isobornyl-Delta8-tetrahydrocannabinols: a novel class of cannabinergic ligands. J Med Chem. 2008 Oct 23;51(20):6393-9. DM5ARHI RU https://pubmed.ncbi.nlm.nih.gov/18826296 DMB6ADI DI DMB6ADI DMB6ADI DN Delta12-PGJ2 DMB6ADI MI TTNVEIR DMB6ADI MN Prostaglandin D2 receptor (PTGDR) DMB6ADI MT DTT DMB6ADI MA Agonist DMB6ADI RN Characterization of the recombinant human prostanoid DP receptor and identification of L-644,698, a novel selective DP agonist. Br J Pharmacol. 1998 Apr;123(7):1317-24. DMB6ADI RU https://pubmed.ncbi.nlm.nih.gov/9579725 DMB6ADI DI DMB6ADI DMB6ADI DN Delta12-PGJ2 DMB6ADI MI TTQDMX5 DMB6ADI MN Prostaglandin D2 receptor 2 (PTGDR2) DMB6ADI MT DTT DMB6ADI MA Agonist DMB6ADI RN Molecular pharmacology of the human prostaglandin D2 receptor, CRTH2. Br J Pharmacol. 2002 Dec;137(8):1163-72. DMB6ADI RU https://pubmed.ncbi.nlm.nih.gov/12466225 DML6MVH DI DML6MVH DML6MVH DN Delta1-dihydrotestosterone DML6MVH MI TTS64P2 DML6MVH MN Androgen receptor (AR) DML6MVH MT DTT DML6MVH MA Agonist DML6MVH RN 17beta-hydroxy-5alpha-androst-1-en-3-one (1-testosterone) is a potent androgen with anabolic properties. Toxicol Lett. 2006 Aug 20;165(2):149-55. DML6MVH RU https://pubmed.ncbi.nlm.nih.gov/16621347 DMV7IAK DI DMV7IAK DMV7IAK DN Delta-Amino Valeric Acid DMV7IAK MI TTJHKYD DMV7IAK MN Delta-aminolevulinic acid dehydratase (ALAD) DMV7IAK MT DTT DMV7IAK MA Inhibitor DMV7IAK RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMV7IAK RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMHOT9P DI DMHOT9P DMHOT9P DN DELTORPHIN DMHOT9P MI TT27RFC DMHOT9P MN Opioid receptor delta (OPRD1) DMHOT9P MT DTT DMHOT9P MA Inhibitor DMHOT9P RN Cyclic enkephalin analogs with exceptional potency at peripheral delta opioid receptors. J Med Chem. 1994 Jan 7;37(1):146-50. DMHOT9P RU https://pubmed.ncbi.nlm.nih.gov/8289188 DMHOT9P DI DMHOT9P DMHOT9P DN DELTORPHIN DMHOT9P MI TTKWM86 DMHOT9P MN Opioid receptor mu (MOP) DMHOT9P MT DTT DMHOT9P MA Inhibitor DMHOT9P RN Synthesis and structure-activity relationships of deltorphin analogues. J Med Chem. 1991 May;34(5):1656-61. DMHOT9P RU https://pubmed.ncbi.nlm.nih.gov/1851843 DM9ZWRK DI DM9ZWRK DM9ZWRK DN DELTORPHIN-II DM9ZWRK MI TT27RFC DM9ZWRK MN Opioid receptor delta (OPRD1) DM9ZWRK MT DTT DM9ZWRK MA Inhibitor DM9ZWRK RN Role of 2',6'-dimethyl-l-tyrosine (Dmt) in some opioid lead compounds. Bioorg Med Chem. 2010 Aug 15;18(16):6024-30. DM9ZWRK RU https://pubmed.ncbi.nlm.nih.gov/20637637 DM9ZWRK DI DM9ZWRK DM9ZWRK DN DELTORPHIN-II DM9ZWRK MI TTKWM86 DM9ZWRK MN Opioid receptor mu (MOP) DM9ZWRK MT DTT DM9ZWRK MA Inhibitor DM9ZWRK RN Role of 2',6'-dimethyl-l-tyrosine (Dmt) in some opioid lead compounds. Bioorg Med Chem. 2010 Aug 15;18(16):6024-30. DM9ZWRK RU https://pubmed.ncbi.nlm.nih.gov/20637637 DMO5UGV DI DMO5UGV DMO5UGV DN DEMETHOXYCURCUMIN DMO5UGV MI TT8NGED DMO5UGV MN Prostaglandin G/H synthase 1 (COX-1) DMO5UGV MT DTT DMO5UGV MA Inhibitor DMO5UGV RN Design, synthesis, biological evaluation and molecular docking of curcumin analogues as antioxidant, cyclooxygenase inhibitory and anti-inflammator... Bioorg Med Chem Lett. 2005 Apr 1;15(7):1793-7. DMO5UGV RU https://pubmed.ncbi.nlm.nih.gov/15780608 DMJBAEP DI DMJBAEP DMJBAEP DN DEMETHYLDEBROMOFLUSTRAMINE B DMJBAEP MI TTEB0GD DMJBAEP MN Cholinesterase (BCHE) DMJBAEP MT DTT DMJBAEP MA Inhibitor DMJBAEP RN Synthesis and biological evaluation of (-)- and (+)-debromoflustramine B and its analogues as selective butyrylcholinesterase inhibitors. J Med Chem. 2008 Sep 11;51(17):5271-84. DMJBAEP RU https://pubmed.ncbi.nlm.nih.gov/18686941 DMUVR5T DI DMUVR5T DMUVR5T DN DEMETHYLMEDICARPIN DMUVR5T MI TT50QJ3 DMUVR5T MN Influenza Neuraminidase (Influ NA) DMUVR5T MT DTT DMUVR5T MA Inhibitor DMUVR5T RN Prenylated pterocarpans as bacterial neuraminidase inhibitors. Bioorg Med Chem. 2010 May 1;18(9):3335-44. DMUVR5T RU https://pubmed.ncbi.nlm.nih.gov/20363636 DMAMS7R DI DMAMS7R DMAMS7R DN DEMETHYLZEYLASTERONE DMAMS7R MI TT0IHXV DMAMS7R MN DNA topoisomerase II (TOP2) DMAMS7R MT DTT DMAMS7R MA Inhibitor DMAMS7R RN Catalytic inhibition of topoisomerase IIalpha by demethylzeylasterone, a 6-oxophenolic triterpenoid from Kokoona zeylanica. J Nat Prod. 2001 Oct;64(10):1294-6. DMAMS7R RU https://pubmed.ncbi.nlm.nih.gov/11678653 DMRICV6 DI DMRICV6 DMRICV6 DN Demotensin 1 DMRICV6 MI TTTUMEP DMRICV6 MN Neurotensin receptor type 1 (NTSR1) DMRICV6 MT DTT DMRICV6 MA Inhibitor DMRICV6 RN Toward stable N4-modified neurotensins for NTS1-receptor-targeted tumor imaging with 99mTc. J Med Chem. 2006 Jul 27;49(15):4767-76. DMRICV6 RU https://pubmed.ncbi.nlm.nih.gov/16854083 DMW2GA4 DI DMW2GA4 DMW2GA4 DN Demotensin 2 DMW2GA4 MI TTTUMEP DMW2GA4 MN Neurotensin receptor type 1 (NTSR1) DMW2GA4 MT DTT DMW2GA4 MA Inhibitor DMW2GA4 RN Toward stable N4-modified neurotensins for NTS1-receptor-targeted tumor imaging with 99mTc. J Med Chem. 2006 Jul 27;49(15):4767-76. DMW2GA4 RU https://pubmed.ncbi.nlm.nih.gov/16854083 DMS0V84 DI DMS0V84 DMS0V84 DN Demotensin 3 DMS0V84 MI TTTUMEP DMS0V84 MN Neurotensin receptor type 1 (NTSR1) DMS0V84 MT DTT DMS0V84 MA Inhibitor DMS0V84 RN Toward stable N4-modified neurotensins for NTS1-receptor-targeted tumor imaging with 99mTc. J Med Chem. 2006 Jul 27;49(15):4767-76. DMS0V84 RU https://pubmed.ncbi.nlm.nih.gov/16854083 DMB2HXM DI DMB2HXM DMB2HXM DN Demotensin 4 DMB2HXM MI TTTUMEP DMB2HXM MN Neurotensin receptor type 1 (NTSR1) DMB2HXM MT DTT DMB2HXM MA Inhibitor DMB2HXM RN Toward stable N4-modified neurotensins for NTS1-receptor-targeted tumor imaging with 99mTc. J Med Chem. 2006 Jul 27;49(15):4767-76. DMB2HXM RU https://pubmed.ncbi.nlm.nih.gov/16854083 DMNWRV9 DI DMNWRV9 DMNWRV9 DN De-O-sulfonated kotalanol DMNWRV9 MI TTXWASR DMNWRV9 MN Intestinal maltase-glucoamylase (MGAM) DMNWRV9 MT DTT DMNWRV9 MA Inhibitor DMNWRV9 RN Probing the active-site requirements of human intestinal N-terminal maltase-glucoamylase: Synthesis and enzyme inhibitory activities of a six-membe... Bioorg Med Chem. 2010 Nov 15;18(22):7794-8. DMNWRV9 RU https://pubmed.ncbi.nlm.nih.gov/20970346 DM5JFKX DI DM5JFKX DM5JFKX DN DEOXY SALVINORIN A DM5JFKX MI TTQW87Y DM5JFKX MN Opioid receptor kappa (OPRK1) DM5JFKX MT DTT DM5JFKX MA Inhibitor DM5JFKX RN Synthesis and in vitro evaluation of salvinorin A analogues: effect of configuration at C(2) and substitution at C(18). Bioorg Med Chem Lett. 2006 Sep 1;16(17):4679-85. DM5JFKX RU https://pubmed.ncbi.nlm.nih.gov/16777411 DMS6X1I DI DMS6X1I DMS6X1I DN DEOXYADENOSINE DMS6X1I MI TT2QM9D DMS6X1I MN Adenylate cyclase (ADCY) DMS6X1I MT DTT DMS6X1I MA Inhibitor DMS6X1I RN Synthesis of 2',5'-dideoxy-2-fluoroadenosine and 2',5'-dideoxy-2,5'-difluoroadenosine: potent P-site inhibitors of adenylyl cyclase. J Med Chem. 2004 Feb 26;47(5):1207-13. DMS6X1I RU https://pubmed.ncbi.nlm.nih.gov/14971900 DMYAJCG DI DMYAJCG DMYAJCG DN Deoxy-Bigchap DMYAJCG MI TTJ584C DMYAJCG MN Peroxisome proliferator-activated receptor alpha (PPARA) DMYAJCG MT DTT DMYAJCG MA Inhibitor DMYAJCG RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMYAJCG RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMW6YLS DI DMW6YLS DMW6YLS DN Deoxycorticosterone DMW6YLS MI DE6TYUK DMW6YLS MN Aldosterone synthase (CYP11B2) DMW6YLS MT DME DMW6YLS MA Metabolism DMW6YLS RN Functional expression of human mitochondrial CYP11B2 in fission yeast and identification of a new internal electron transfer protein, etp1. Biochemistry. 2002 Feb 19;41(7):2311-21. DMW6YLS RU https://www.ncbi.nlm.nih.gov/pubmed/?term=11841224 DMW6YLS DI DMW6YLS DMW6YLS DN Deoxycorticosterone DMW6YLS MI TTOZRK6 DMW6YLS MN Glucocorticoid receptor messenger RNA (GCR mRNA) DMW6YLS MT DTT DMW6YLS MA Agonist DMW6YLS RN Functional probing of the human glucocorticoid receptor steroid-interacting surface by site-directed mutagenesis. Gln-642 plays an important role in steroid recognition and binding. J Biol Chem. 2000Jun 23;275(25):19041-9. DMW6YLS RU https://pubmed.ncbi.nlm.nih.gov/10747884 DMW6YLS DI DMW6YLS DMW6YLS DN Deoxycorticosterone DMW6YLS MI TT26PHO DMW6YLS MN Mineralocorticoid receptor (MR) DMW6YLS MT DTT DMW6YLS MA Agonist DMW6YLS RN Pharmacological and functional characterization of human mineralocorticoid and glucocorticoid receptor ligands. Eur J Pharmacol. 1993 Oct 15;247(2):145-54. DMW6YLS RU https://pubmed.ncbi.nlm.nih.gov/8282004 DMW6YLS DI DMW6YLS DMW6YLS DN Deoxycorticosterone DMW6YLS MI DEPE0RD DMW6YLS MN Steroid 11-beta-hydroxylase (CYP11B1) DMW6YLS MT DME DMW6YLS MA Metabolism DMW6YLS RN Summary of information on human CYP enzymes: human P450 metabolism data. Drug Metab Rev. 2002 Feb-May;34(1-2):83-448. DMW6YLS RU https://www.ncbi.nlm.nih.gov/pubmed/?term=11996015 DMKFMRY DI DMKFMRY DMKFMRY DN Deoxyfluorothymidine DMKFMRY MI TT84ETX DMKFMRY MN Human immunodeficiency virus Reverse transcriptase (HIV RT) DMKFMRY MT DTT DMKFMRY MA Inhibitor DMKFMRY RN Current use of anti-HIV drugs in AIDS. J Antimicrob Chemother. 1993 Jul;32 Suppl A:133-8. DMKFMRY RU https://pubmed.ncbi.nlm.nih.gov/8407695 DMR90HY DI DMR90HY DMR90HY DN Deoxythymidine DMR90HY MI TT5B8AX DMR90HY MN Mycobacterium Thymidine monophosphate kinase (MycB tmk) DMR90HY MT DTT DMR90HY MA Inhibitor DMR90HY RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMR90HY RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMR90HY DI DMR90HY DMR90HY DN Deoxythymidine DMR90HY MI TTP3QRF DMR90HY MN Thymidine kinase 1 (TK1) DMR90HY MT DTT DMR90HY MA Inhibitor DMR90HY RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMR90HY RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMR90HY DI DMR90HY DMR90HY DN Deoxythymidine DMR90HY MI DE4HCYL DMR90HY MN Thymidine phosphorylase (TYMP) DMR90HY MT DME DMR90HY MA Metabolism DMR90HY RN Thymidine catabolism as a metabolic strategy for cancer survival. Cell Rep. 2017 May 16;19(7):1313-1321. DMR90HY RU https://www.ncbi.nlm.nih.gov/pubmed/?term=28514652 DMIFMDC DI DMIFMDC DMIFMDC DN Deoxyuridine-5'-Diphosphate DMIFMDC MI TTY8KJS DMIFMDC MN Bacterial Deoxyuridine triphosphate nucleotidohydrolase (Bact dut) DMIFMDC MT DTT DMIFMDC MA Inhibitor DMIFMDC RN DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Nucleic Acids Res. 2011 Jan;39(Database issue):D1035-41. DMIFMDC RU https://pubmed.ncbi.nlm.nih.gov/21059682 DMCG5V2 DI DMCG5V2 DMCG5V2 DN Deoxyuridine-5'-Triphosphate DMCG5V2 MI TTY8KJS DMCG5V2 MN Bacterial Deoxyuridine triphosphate nucleotidohydrolase (Bact dut) DMCG5V2 MT DTT DMCG5V2 MA Inhibitor DMCG5V2 RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMCG5V2 RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMGHM1L DI DMGHM1L DMGHM1L DN Dephospho Coenzyme A DMGHM1L MI TT4YO0Z DMGHM1L MN Phosphopantetheine adenylyltransferase (PPAT) DMGHM1L MT DTT DMGHM1L MA Inhibitor DMGHM1L RN DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Nucleic Acids Res. 2011 Jan;39(Database issue):D1035-41. DMGHM1L RU https://pubmed.ncbi.nlm.nih.gov/21059682 DMRFBD0 DI DMRFBD0 DMRFBD0 DN Deprenyl DMRFBD0 MI TTGP7BY DMRFBD0 MN Monoamine oxidase type B (MAO-B) DMRFBD0 MT DTT DMRFBD0 MA Inhibitor DMRFBD0 RN The effect of deprenyl washout in patients with long-standing Parkinson's disease. J Neural Transm. 2002 May;109(5-6):797-803. DMRFBD0 RU https://pubmed.ncbi.nlm.nih.gov/12111469 DMH340E DI DMH340E DMH340E DN Deprotected cogener of M6G DMH340E MI TT27RFC DMH340E MN Opioid receptor delta (OPRD1) DMH340E MT DTT DMH340E MA Inhibitor DMH340E RN Synthesis and in vitro biological evaluation of a carbon glycoside analogue of morphine-6-glucuronide. Bioorg Med Chem Lett. 2005 Mar 15;15(6):1583-6. DMH340E RU https://pubmed.ncbi.nlm.nih.gov/15745801 DMH340E DI DMH340E DMH340E DN Deprotected cogener of M6G DMH340E MI TTQW87Y DMH340E MN Opioid receptor kappa (OPRK1) DMH340E MT DTT DMH340E MA Inhibitor DMH340E RN Synthesis and in vitro biological evaluation of a carbon glycoside analogue of morphine-6-glucuronide. Bioorg Med Chem Lett. 2005 Mar 15;15(6):1583-6. DMH340E RU https://pubmed.ncbi.nlm.nih.gov/15745801 DMH340E DI DMH340E DMH340E DN Deprotected cogener of M6G DMH340E MI TTKWM86 DMH340E MN Opioid receptor mu (MOP) DMH340E MT DTT DMH340E MA Inhibitor DMH340E RN Synthesis and in vitro biological evaluation of a carbon glycoside analogue of morphine-6-glucuronide. Bioorg Med Chem Lett. 2005 Mar 15;15(6):1583-6. DMH340E RU https://pubmed.ncbi.nlm.nih.gov/15745801 DM4JM50 DI DM4JM50 DM4JM50 DN DEPX DM4JM50 MI TTK25J1 DM4JM50 MN Adenosine A1 receptor (ADORA1) DM4JM50 MT DTT DM4JM50 MA Inhibitor DM4JM50 RN 125I-labeled 8-phenylxanthine derivatives: antagonist radioligands for adenosine A1 receptors. J Med Chem. 1988 Apr;31(4):745-51. DM4JM50 RU https://pubmed.ncbi.nlm.nih.gov/3351850 DM4JM50 DI DM4JM50 DM4JM50 DN DEPX DM4JM50 MI TTNE7KG DM4JM50 MN Adenosine A2b receptor (ADORA2B) DM4JM50 MT DTT DM4JM50 MA Antagonist DM4JM50 RN Characterization of human A(2B) adenosine receptors: radioligand binding, western blotting, and coupling to G(q) in human embryonic kidney 293 cells and HMC-1 mast cells. Mol Pharmacol. 1999 Oct;56(4):705-13. DM4JM50 RU https://pubmed.ncbi.nlm.nih.gov/10496952 DM2XT7S DI DM2XT7S DM2XT7S DN D-Eritadenine DM2XT7S MI TTE2KUJ DM2XT7S MN Adenosylhomocysteinase (AHCY) DM2XT7S MT DTT DM2XT7S MA Inhibitor DM2XT7S RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DM2XT7S RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMCYQHO DI DMCYQHO DMCYQHO DN DERMORPHIN DMCYQHO MI TT27RFC DMCYQHO MN Opioid receptor delta (OPRD1) DMCYQHO MT DTT DMCYQHO MA Inhibitor DMCYQHO RN Conversion of the potent delta-opioid agonist H-Dmt-Tic-NH-CH(2)-bid into delta-opioid antagonists by N(1)-benzimidazole alkylation(1). J Med Chem. 2005 Dec 29;48(26):8112-4. DMCYQHO RU https://pubmed.ncbi.nlm.nih.gov/16366592 DMCYQHO DI DMCYQHO DMCYQHO DN DERMORPHIN DMCYQHO MI TTKWM86 DMCYQHO MN Opioid receptor mu (MOP) DMCYQHO MT DTT DMCYQHO MA Inhibitor DMCYQHO RN Synthesis and receptor binding properties of chimeric peptides containing a mu-opioid receptor ligand and nociceptin/orphanin FQ receptor ligand Ac... Bioorg Med Chem Lett. 2006 Sep 15;16(18):4839-41. DMCYQHO RU https://pubmed.ncbi.nlm.nih.gov/16814543 DMMWDC5 DI DMMWDC5 DMMWDC5 DN Des-AA1,2,4,12,13-[D-Trp8]SRIF DMMWDC5 MI TTIND6G DMMWDC5 MN Somatostatin receptor type 1 (SSTR1) DMMWDC5 MT DTT DMMWDC5 MA Inhibitor DMMWDC5 RN Somatostatin receptor 1 selective analogues: 3. Dicyclic peptides. J Med Chem. 2005 Jan 27;48(2):515-22. DMMWDC5 RU https://pubmed.ncbi.nlm.nih.gov/15658865 DMMWDC5 DI DMMWDC5 DMMWDC5 DN Des-AA1,2,4,12,13-[D-Trp8]SRIF DMMWDC5 MI TTZ6T9E DMMWDC5 MN Somatostatin receptor type 2 (SSTR2) DMMWDC5 MT DTT DMMWDC5 MA Inhibitor DMMWDC5 RN Somatostatin receptor 1 selective analogues: 3. Dicyclic peptides. J Med Chem. 2005 Jan 27;48(2):515-22. DMMWDC5 RU https://pubmed.ncbi.nlm.nih.gov/15658865 DMMWDC5 DI DMMWDC5 DMMWDC5 DN Des-AA1,2,4,12,13-[D-Trp8]SRIF DMMWDC5 MI TTJX3UE DMMWDC5 MN Somatostatin receptor type 3 (SSTR3) DMMWDC5 MT DTT DMMWDC5 MA Inhibitor DMMWDC5 RN Somatostatin receptor 1 selective analogues: 3. Dicyclic peptides. J Med Chem. 2005 Jan 27;48(2):515-22. DMMWDC5 RU https://pubmed.ncbi.nlm.nih.gov/15658865 DMMWDC5 DI DMMWDC5 DMMWDC5 DN Des-AA1,2,4,12,13-[D-Trp8]SRIF DMMWDC5 MI TTAE1BR DMMWDC5 MN Somatostatin receptor type 4 (SSTR4) DMMWDC5 MT DTT DMMWDC5 MA Inhibitor DMMWDC5 RN Somatostatin receptor 1 selective analogues: 3. Dicyclic peptides. J Med Chem. 2005 Jan 27;48(2):515-22. DMMWDC5 RU https://pubmed.ncbi.nlm.nih.gov/15658865 DMMWDC5 DI DMMWDC5 DMMWDC5 DN Des-AA1,2,4,12,13-[D-Trp8]SRIF DMMWDC5 MI TT2BC4G DMMWDC5 MN Somatostatin receptor type 5 (SSTR5) DMMWDC5 MT DTT DMMWDC5 MA Inhibitor DMMWDC5 RN Somatostatin receptor 1 selective analogues: 3. Dicyclic peptides. J Med Chem. 2005 Jan 27;48(2):515-22. DMMWDC5 RU https://pubmed.ncbi.nlm.nih.gov/15658865 DMR6Z2N DI DMR6Z2N DMR6Z2N DN Des-AA1,2,4,13-[D-Trp8]SRIF DMR6Z2N MI TTIND6G DMR6Z2N MN Somatostatin receptor type 1 (SSTR1) DMR6Z2N MT DTT DMR6Z2N MA Inhibitor DMR6Z2N RN Somatostatin receptor 1 selective analogues: 3. Dicyclic peptides. J Med Chem. 2005 Jan 27;48(2):515-22. DMR6Z2N RU https://pubmed.ncbi.nlm.nih.gov/15658865 DMR6Z2N DI DMR6Z2N DMR6Z2N DN Des-AA1,2,4,13-[D-Trp8]SRIF DMR6Z2N MI TTZ6T9E DMR6Z2N MN Somatostatin receptor type 2 (SSTR2) DMR6Z2N MT DTT DMR6Z2N MA Inhibitor DMR6Z2N RN Somatostatin receptor 1 selective analogues: 3. Dicyclic peptides. J Med Chem. 2005 Jan 27;48(2):515-22. DMR6Z2N RU https://pubmed.ncbi.nlm.nih.gov/15658865 DMR6Z2N DI DMR6Z2N DMR6Z2N DN Des-AA1,2,4,13-[D-Trp8]SRIF DMR6Z2N MI TTJX3UE DMR6Z2N MN Somatostatin receptor type 3 (SSTR3) DMR6Z2N MT DTT DMR6Z2N MA Inhibitor DMR6Z2N RN Somatostatin receptor 1 selective analogues: 3. Dicyclic peptides. J Med Chem. 2005 Jan 27;48(2):515-22. DMR6Z2N RU https://pubmed.ncbi.nlm.nih.gov/15658865 DMR6Z2N DI DMR6Z2N DMR6Z2N DN Des-AA1,2,4,13-[D-Trp8]SRIF DMR6Z2N MI TTAE1BR DMR6Z2N MN Somatostatin receptor type 4 (SSTR4) DMR6Z2N MT DTT DMR6Z2N MA Inhibitor DMR6Z2N RN Somatostatin receptor 1 selective analogues: 3. Dicyclic peptides. J Med Chem. 2005 Jan 27;48(2):515-22. DMR6Z2N RU https://pubmed.ncbi.nlm.nih.gov/15658865 DMR6Z2N DI DMR6Z2N DMR6Z2N DN Des-AA1,2,4,13-[D-Trp8]SRIF DMR6Z2N MI TT2BC4G DMR6Z2N MN Somatostatin receptor type 5 (SSTR5) DMR6Z2N MT DTT DMR6Z2N MA Inhibitor DMR6Z2N RN Somatostatin receptor 1 selective analogues: 3. Dicyclic peptides. J Med Chem. 2005 Jan 27;48(2):515-22. DMR6Z2N RU https://pubmed.ncbi.nlm.nih.gov/15658865 DMEVOD2 DI DMEVOD2 DMEVOD2 DN Des-AA1,2,4,5,10,12,13-[D-Trp8]SRIF DMEVOD2 MI TTJX3UE DMEVOD2 MN Somatostatin receptor type 3 (SSTR3) DMEVOD2 MT DTT DMEVOD2 MA Inhibitor DMEVOD2 RN Somatostatin receptor 1 selective analogues: 3. Dicyclic peptides. J Med Chem. 2005 Jan 27;48(2):515-22. DMEVOD2 RU https://pubmed.ncbi.nlm.nih.gov/15658865 DMEVOD2 DI DMEVOD2 DMEVOD2 DN Des-AA1,2,4,5,10,12,13-[D-Trp8]SRIF DMEVOD2 MI TTAE1BR DMEVOD2 MN Somatostatin receptor type 4 (SSTR4) DMEVOD2 MT DTT DMEVOD2 MA Inhibitor DMEVOD2 RN Somatostatin receptor 1 selective analogues: 3. Dicyclic peptides. J Med Chem. 2005 Jan 27;48(2):515-22. DMEVOD2 RU https://pubmed.ncbi.nlm.nih.gov/15658865 DMJI6BK DI DMJI6BK DMJI6BK DN Des-AA1,2,4,5,11,12,13-[D-Trp8]SRIF DMJI6BK MI TTZ6T9E DMJI6BK MN Somatostatin receptor type 2 (SSTR2) DMJI6BK MT DTT DMJI6BK MA Inhibitor DMJI6BK RN Somatostatin receptor 1 selective analogues: 3. Dicyclic peptides. J Med Chem. 2005 Jan 27;48(2):515-22. DMJI6BK RU https://pubmed.ncbi.nlm.nih.gov/15658865 DMYZXEO DI DMYZXEO DMYZXEO DN Des-AA1,2,4,5,13-[D-Trp8]-SRIF DMYZXEO MI TTIND6G DMYZXEO MN Somatostatin receptor type 1 (SSTR1) DMYZXEO MT DTT DMYZXEO MA Inhibitor DMYZXEO RN Somatostatin receptor 1 selective analogues: 3. Dicyclic peptides. J Med Chem. 2005 Jan 27;48(2):515-22. DMYZXEO RU https://pubmed.ncbi.nlm.nih.gov/15658865 DMYZXEO DI DMYZXEO DMYZXEO DN Des-AA1,2,4,5,13-[D-Trp8]-SRIF DMYZXEO MI TTZ6T9E DMYZXEO MN Somatostatin receptor type 2 (SSTR2) DMYZXEO MT DTT DMYZXEO MA Inhibitor DMYZXEO RN Somatostatin receptor 1 selective analogues: 3. Dicyclic peptides. J Med Chem. 2005 Jan 27;48(2):515-22. DMYZXEO RU https://pubmed.ncbi.nlm.nih.gov/15658865 DMYZXEO DI DMYZXEO DMYZXEO DN Des-AA1,2,4,5,13-[D-Trp8]-SRIF DMYZXEO MI TTJX3UE DMYZXEO MN Somatostatin receptor type 3 (SSTR3) DMYZXEO MT DTT DMYZXEO MA Inhibitor DMYZXEO RN Somatostatin receptor 1 selective analogues: 3. Dicyclic peptides. J Med Chem. 2005 Jan 27;48(2):515-22. DMYZXEO RU https://pubmed.ncbi.nlm.nih.gov/15658865 DMYZXEO DI DMYZXEO DMYZXEO DN Des-AA1,2,4,5,13-[D-Trp8]-SRIF DMYZXEO MI TTAE1BR DMYZXEO MN Somatostatin receptor type 4 (SSTR4) DMYZXEO MT DTT DMYZXEO MA Inhibitor DMYZXEO RN Somatostatin receptor 1 selective analogues: 3. Dicyclic peptides. J Med Chem. 2005 Jan 27;48(2):515-22. DMYZXEO RU https://pubmed.ncbi.nlm.nih.gov/15658865 DMYZXEO DI DMYZXEO DMYZXEO DN Des-AA1,2,4,5,13-[D-Trp8]-SRIF DMYZXEO MI TT2BC4G DMYZXEO MN Somatostatin receptor type 5 (SSTR5) DMYZXEO MT DTT DMYZXEO MA Inhibitor DMYZXEO RN Somatostatin receptor 1 selective analogues: 3. Dicyclic peptides. J Med Chem. 2005 Jan 27;48(2):515-22. DMYZXEO RU https://pubmed.ncbi.nlm.nih.gov/15658865 DM6HZ8D DI DM6HZ8D DM6HZ8D DN Des-AA1,2,4,5,6,12,13-[D-Trp8]SRIF DM6HZ8D MI TTZ6T9E DM6HZ8D MN Somatostatin receptor type 2 (SSTR2) DM6HZ8D MT DTT DM6HZ8D MA Inhibitor DM6HZ8D RN Somatostatin receptor 1 selective analogues: 3. Dicyclic peptides. J Med Chem. 2005 Jan 27;48(2):515-22. DM6HZ8D RU https://pubmed.ncbi.nlm.nih.gov/15658865 DM6HZ8D DI DM6HZ8D DM6HZ8D DN Des-AA1,2,4,5,6,12,13-[D-Trp8]SRIF DM6HZ8D MI TTAE1BR DM6HZ8D MN Somatostatin receptor type 4 (SSTR4) DM6HZ8D MT DTT DM6HZ8D MA Inhibitor DM6HZ8D RN Somatostatin receptor 1 selective analogues: 3. Dicyclic peptides. J Med Chem. 2005 Jan 27;48(2):515-22. DM6HZ8D RU https://pubmed.ncbi.nlm.nih.gov/15658865 DMEN4G8 DI DMEN4G8 DMEN4G8 DN Des-AA1,2,4,5-[D-Trp8]SRIF DMEN4G8 MI TTIND6G DMEN4G8 MN Somatostatin receptor type 1 (SSTR1) DMEN4G8 MT DTT DMEN4G8 MA Inhibitor DMEN4G8 RN Somatostatin receptor 1 selective analogues: 3. Dicyclic peptides. J Med Chem. 2005 Jan 27;48(2):515-22. DMEN4G8 RU https://pubmed.ncbi.nlm.nih.gov/15658865 DMEN4G8 DI DMEN4G8 DMEN4G8 DN Des-AA1,2,4,5-[D-Trp8]SRIF DMEN4G8 MI TTZ6T9E DMEN4G8 MN Somatostatin receptor type 2 (SSTR2) DMEN4G8 MT DTT DMEN4G8 MA Inhibitor DMEN4G8 RN Somatostatin receptor 1 selective analogues: 3. Dicyclic peptides. J Med Chem. 2005 Jan 27;48(2):515-22. DMEN4G8 RU https://pubmed.ncbi.nlm.nih.gov/15658865 DMEN4G8 DI DMEN4G8 DMEN4G8 DN Des-AA1,2,4,5-[D-Trp8]SRIF DMEN4G8 MI TTJX3UE DMEN4G8 MN Somatostatin receptor type 3 (SSTR3) DMEN4G8 MT DTT DMEN4G8 MA Inhibitor DMEN4G8 RN Somatostatin receptor 1 selective analogues: 3. Dicyclic peptides. J Med Chem. 2005 Jan 27;48(2):515-22. DMEN4G8 RU https://pubmed.ncbi.nlm.nih.gov/15658865 DMEN4G8 DI DMEN4G8 DMEN4G8 DN Des-AA1,2,4,5-[D-Trp8]SRIF DMEN4G8 MI TTAE1BR DMEN4G8 MN Somatostatin receptor type 4 (SSTR4) DMEN4G8 MT DTT DMEN4G8 MA Inhibitor DMEN4G8 RN Somatostatin receptor 1 selective analogues: 3. Dicyclic peptides. J Med Chem. 2005 Jan 27;48(2):515-22. DMEN4G8 RU https://pubmed.ncbi.nlm.nih.gov/15658865 DMEN4G8 DI DMEN4G8 DMEN4G8 DN Des-AA1,2,4,5-[D-Trp8]SRIF DMEN4G8 MI TT2BC4G DMEN4G8 MN Somatostatin receptor type 5 (SSTR5) DMEN4G8 MT DTT DMEN4G8 MA Inhibitor DMEN4G8 RN Somatostatin receptor 1 selective analogues: 3. Dicyclic peptides. J Med Chem. 2005 Jan 27;48(2):515-22. DMEN4G8 RU https://pubmed.ncbi.nlm.nih.gov/15658865 DMZPXGY DI DMZPXGY DMZPXGY DN Des-AA1,2,5,12,13-[D-Trp8,IAmp9]SRIF DMZPXGY MI TTIND6G DMZPXGY MN Somatostatin receptor type 1 (SSTR1) DMZPXGY MT DTT DMZPXGY MA Inhibitor DMZPXGY RN Somatostatin receptor 1 selective analogues: 3. Dicyclic peptides. J Med Chem. 2005 Jan 27;48(2):515-22. DMZPXGY RU https://pubmed.ncbi.nlm.nih.gov/15658865 DMZPXGY DI DMZPXGY DMZPXGY DN Des-AA1,2,5,12,13-[D-Trp8,IAmp9]SRIF DMZPXGY MI TTJX3UE DMZPXGY MN Somatostatin receptor type 3 (SSTR3) DMZPXGY MT DTT DMZPXGY MA Inhibitor DMZPXGY RN Somatostatin receptor 1 selective analogues: 3. Dicyclic peptides. J Med Chem. 2005 Jan 27;48(2):515-22. DMZPXGY RU https://pubmed.ncbi.nlm.nih.gov/15658865 DMZPXGY DI DMZPXGY DMZPXGY DN Des-AA1,2,5,12,13-[D-Trp8,IAmp9]SRIF DMZPXGY MI TTAE1BR DMZPXGY MN Somatostatin receptor type 4 (SSTR4) DMZPXGY MT DTT DMZPXGY MA Inhibitor DMZPXGY RN Somatostatin receptor 1 selective analogues: 3. Dicyclic peptides. J Med Chem. 2005 Jan 27;48(2):515-22. DMZPXGY RU https://pubmed.ncbi.nlm.nih.gov/15658865 DM1KJAE DI DM1KJAE DM1KJAE DN Des-AA1,2,5,12,13-[D-Trp8]SRIF DM1KJAE MI TTIND6G DM1KJAE MN Somatostatin receptor type 1 (SSTR1) DM1KJAE MT DTT DM1KJAE MA Inhibitor DM1KJAE RN Somatostatin receptor 1 selective analogues: 3. Dicyclic peptides. J Med Chem. 2005 Jan 27;48(2):515-22. DM1KJAE RU https://pubmed.ncbi.nlm.nih.gov/15658865 DM1KJAE DI DM1KJAE DM1KJAE DN Des-AA1,2,5,12,13-[D-Trp8]SRIF DM1KJAE MI TTZ6T9E DM1KJAE MN Somatostatin receptor type 2 (SSTR2) DM1KJAE MT DTT DM1KJAE MA Inhibitor DM1KJAE RN Somatostatin receptor 1 selective analogues: 3. Dicyclic peptides. J Med Chem. 2005 Jan 27;48(2):515-22. DM1KJAE RU https://pubmed.ncbi.nlm.nih.gov/15658865 DM1KJAE DI DM1KJAE DM1KJAE DN Des-AA1,2,5,12,13-[D-Trp8]SRIF DM1KJAE MI TTJX3UE DM1KJAE MN Somatostatin receptor type 3 (SSTR3) DM1KJAE MT DTT DM1KJAE MA Inhibitor DM1KJAE RN Somatostatin receptor 1 selective analogues: 3. Dicyclic peptides. J Med Chem. 2005 Jan 27;48(2):515-22. DM1KJAE RU https://pubmed.ncbi.nlm.nih.gov/15658865 DM1KJAE DI DM1KJAE DM1KJAE DN Des-AA1,2,5,12,13-[D-Trp8]SRIF DM1KJAE MI TTAE1BR DM1KJAE MN Somatostatin receptor type 4 (SSTR4) DM1KJAE MT DTT DM1KJAE MA Inhibitor DM1KJAE RN Somatostatin receptor 1 selective analogues: 3. Dicyclic peptides. J Med Chem. 2005 Jan 27;48(2):515-22. DM1KJAE RU https://pubmed.ncbi.nlm.nih.gov/15658865 DM1KJAE DI DM1KJAE DM1KJAE DN Des-AA1,2,5,12,13-[D-Trp8]SRIF DM1KJAE MI TT2BC4G DM1KJAE MN Somatostatin receptor type 5 (SSTR5) DM1KJAE MT DTT DM1KJAE MA Inhibitor DM1KJAE RN Somatostatin receptor 1 selective analogues: 3. Dicyclic peptides. J Med Chem. 2005 Jan 27;48(2):515-22. DM1KJAE RU https://pubmed.ncbi.nlm.nih.gov/15658865 DMVYHGI DI DMVYHGI DMVYHGI DN Des-AA1,2,5-[(NalphaMe)Cys3,D-Nal8,IAmp9]SRIF DMVYHGI MI TTIND6G DMVYHGI MN Somatostatin receptor type 1 (SSTR1) DMVYHGI MT DTT DMVYHGI MA Inhibitor DMVYHGI RN Somatostatin receptor 1 selective analogues: 2. N(alpha)-Methylated scan. J Med Chem. 2005 Jan 27;48(2):507-14. DMVYHGI RU https://pubmed.ncbi.nlm.nih.gov/15658864 DMY6NID DI DMY6NID DMY6NID DN Des-AA1,2,5-[(NalphaMe)Cys3,D-Trp8,IAmp9]SRIF DMY6NID MI TTIND6G DMY6NID MN Somatostatin receptor type 1 (SSTR1) DMY6NID MT DTT DMY6NID MA Inhibitor DMY6NID RN Somatostatin receptor 1 selective analogues: 2. N(alpha)-Methylated scan. J Med Chem. 2005 Jan 27;48(2):507-14. DMY6NID RU https://pubmed.ncbi.nlm.nih.gov/15658864 DMQPVGO DI DMQPVGO DMQPVGO DN Des-AA1,2,5-[(NalphaMe)D-Nal8,IAmp9]SRIF DMQPVGO MI TTIND6G DMQPVGO MN Somatostatin receptor type 1 (SSTR1) DMQPVGO MT DTT DMQPVGO MA Inhibitor DMQPVGO RN Somatostatin receptor 1 selective analogues: 2. N(alpha)-Methylated scan. J Med Chem. 2005 Jan 27;48(2):507-14. DMQPVGO RU https://pubmed.ncbi.nlm.nih.gov/15658864 DM478XZ DI DM478XZ DM478XZ DN Des-AA1,2,5-[(NalphaMe)Lys4,D-Nal8,IAmp9]SRIF DM478XZ MI TTIND6G DM478XZ MN Somatostatin receptor type 1 (SSTR1) DM478XZ MT DTT DM478XZ MA Inhibitor DM478XZ RN Somatostatin receptor 1 selective analogues: 2. N(alpha)-Methylated scan. J Med Chem. 2005 Jan 27;48(2):507-14. DM478XZ RU https://pubmed.ncbi.nlm.nih.gov/15658864 DMQOL73 DI DMQOL73 DMQOL73 DN Des-AA1,2,5-[D-Nal8,(NalphaMe)IAmp9,Tyr11]SRIF DMQOL73 MI TTIND6G DMQOL73 MN Somatostatin receptor type 1 (SSTR1) DMQOL73 MT DTT DMQOL73 MA Inhibitor DMQOL73 RN Somatostatin receptor 1 selective analogues: 2. N(alpha)-Methylated scan. J Med Chem. 2005 Jan 27;48(2):507-14. DMQOL73 RU https://pubmed.ncbi.nlm.nih.gov/15658864 DMN4ZYO DI DMN4ZYO DMN4ZYO DN Des-AA1,2,5-[D-Nal8,(NalphaMe)IAmp9]SRIF DMN4ZYO MI TTIND6G DMN4ZYO MN Somatostatin receptor type 1 (SSTR1) DMN4ZYO MT DTT DMN4ZYO MA Inhibitor DMN4ZYO RN Somatostatin receptor 1 selective analogues: 2. N(alpha)-Methylated scan. J Med Chem. 2005 Jan 27;48(2):507-14. DMN4ZYO RU https://pubmed.ncbi.nlm.nih.gov/15658864 DMXD60K DI DMXD60K DMXD60K DN Des-AA1,2,5-[D-Nal8,IAmp9,(NalphaMe)Cys14]SRIF DMXD60K MI TTIND6G DMXD60K MN Somatostatin receptor type 1 (SSTR1) DMXD60K MT DTT DMXD60K MA Inhibitor DMXD60K RN Somatostatin receptor 1 selective analogues: 2. N(alpha)-Methylated scan. J Med Chem. 2005 Jan 27;48(2):507-14. DMXD60K RU https://pubmed.ncbi.nlm.nih.gov/15658864 DM0574W DI DM0574W DM0574W DN Des-AA1,2,5-[D-Nal8,IAmp9,(NalphaMe)Phe11]SRIF DM0574W MI TTIND6G DM0574W MN Somatostatin receptor type 1 (SSTR1) DM0574W MT DTT DM0574W MA Inhibitor DM0574W RN Somatostatin receptor 1 selective analogues: 2. N(alpha)-Methylated scan. J Med Chem. 2005 Jan 27;48(2):507-14. DM0574W RU https://pubmed.ncbi.nlm.nih.gov/15658864 DMOZ9WC DI DMOZ9WC DMOZ9WC DN Des-AA1,2,5-[D-Nal8,IAmp9,(NalphaMe)Ser13]SRIF DMOZ9WC MI TTIND6G DMOZ9WC MN Somatostatin receptor type 1 (SSTR1) DMOZ9WC MT DTT DMOZ9WC MA Inhibitor DMOZ9WC RN Somatostatin receptor 1 selective analogues: 2. N(alpha)-Methylated scan. J Med Chem. 2005 Jan 27;48(2):507-14. DMOZ9WC RU https://pubmed.ncbi.nlm.nih.gov/15658864 DMYFCB0 DI DMYFCB0 DMYFCB0 DN Des-AA1,2,5-[D-Nal8,IAmp9,(NalphaMe)Thr12]SRIF DMYFCB0 MI TTIND6G DMYFCB0 MN Somatostatin receptor type 1 (SSTR1) DMYFCB0 MT DTT DMYFCB0 MA Inhibitor DMYFCB0 RN Somatostatin receptor 1 selective analogues: 2. N(alpha)-Methylated scan. J Med Chem. 2005 Jan 27;48(2):507-14. DMYFCB0 RU https://pubmed.ncbi.nlm.nih.gov/15658864 DMYFCB0 DI DMYFCB0 DMYFCB0 DN Des-AA1,2,5-[D-Nal8,IAmp9,(NalphaMe)Thr12]SRIF DMYFCB0 MI TTAE1BR DMYFCB0 MN Somatostatin receptor type 4 (SSTR4) DMYFCB0 MT DTT DMYFCB0 MA Inhibitor DMYFCB0 RN Somatostatin receptor 1 selective analogues: 2. N(alpha)-Methylated scan. J Med Chem. 2005 Jan 27;48(2):507-14. DMYFCB0 RU https://pubmed.ncbi.nlm.nih.gov/15658864 DM6JAFM DI DM6JAFM DM6JAFM DN Des-AA1,2,5-[D-Nal8,IAmp9]SRIF DM6JAFM MI TTIND6G DM6JAFM MN Somatostatin receptor type 1 (SSTR1) DM6JAFM MT DTT DM6JAFM MA Inhibitor DM6JAFM RN Somatostatin receptor 1 selective analogues: 2. N(alpha)-Methylated scan. J Med Chem. 2005 Jan 27;48(2):507-14. DM6JAFM RU https://pubmed.ncbi.nlm.nih.gov/15658864 DMLHUPY DI DMLHUPY DMLHUPY DN Des-AA1,2,5-[D-Trp8,(NalphaMe)IAmp9,Tyr11]SRIF DMLHUPY MI TTIND6G DMLHUPY MN Somatostatin receptor type 1 (SSTR1) DMLHUPY MT DTT DMLHUPY MA Inhibitor DMLHUPY RN Somatostatin receptor 1 selective analogues: 2. N(alpha)-Methylated scan. J Med Chem. 2005 Jan 27;48(2):507-14. DMLHUPY RU https://pubmed.ncbi.nlm.nih.gov/15658864 DMX2I4P DI DMX2I4P DMX2I4P DN Des-AA1,2,5-[D-Trp8,(NalphaMe)IAmp9]SRIF DMX2I4P MI TTIND6G DMX2I4P MN Somatostatin receptor type 1 (SSTR1) DMX2I4P MT DTT DMX2I4P MA Inhibitor DMX2I4P RN Somatostatin receptor 1 selective analogues: 2. N(alpha)-Methylated scan. J Med Chem. 2005 Jan 27;48(2):507-14. DMX2I4P RU https://pubmed.ncbi.nlm.nih.gov/15658864 DMX2I4P DI DMX2I4P DMX2I4P DN Des-AA1,2,5-[D-Trp8,(NalphaMe)IAmp9]SRIF DMX2I4P MI TTJX3UE DMX2I4P MN Somatostatin receptor type 3 (SSTR3) DMX2I4P MT DTT DMX2I4P MA Inhibitor DMX2I4P RN Somatostatin receptor 1 selective analogues: 2. N(alpha)-Methylated scan. J Med Chem. 2005 Jan 27;48(2):507-14. DMX2I4P RU https://pubmed.ncbi.nlm.nih.gov/15658864 DMX2I4P DI DMX2I4P DMX2I4P DN Des-AA1,2,5-[D-Trp8,(NalphaMe)IAmp9]SRIF DMX2I4P MI TTAE1BR DMX2I4P MN Somatostatin receptor type 4 (SSTR4) DMX2I4P MT DTT DMX2I4P MA Inhibitor DMX2I4P RN Somatostatin receptor 1 selective analogues: 2. N(alpha)-Methylated scan. J Med Chem. 2005 Jan 27;48(2):507-14. DMX2I4P RU https://pubmed.ncbi.nlm.nih.gov/15658864 DMFXKRO DI DMFXKRO DMFXKRO DN Des-AA1,2,5-[D-Trp8,IAmp9,(NalphaMe)Cys14]SRIF DMFXKRO MI TTIND6G DMFXKRO MN Somatostatin receptor type 1 (SSTR1) DMFXKRO MT DTT DMFXKRO MA Inhibitor DMFXKRO RN Somatostatin receptor 1 selective analogues: 2. N(alpha)-Methylated scan. J Med Chem. 2005 Jan 27;48(2):507-14. DMFXKRO RU https://pubmed.ncbi.nlm.nih.gov/15658864 DM9EN01 DI DM9EN01 DM9EN01 DN Des-AA1,2,5-[D-Trp8,IAmp9,(NalphaMe)Ser13]SRIF DM9EN01 MI TTIND6G DM9EN01 MN Somatostatin receptor type 1 (SSTR1) DM9EN01 MT DTT DM9EN01 MA Inhibitor DM9EN01 RN Somatostatin receptor 1 selective analogues: 2. N(alpha)-Methylated scan. J Med Chem. 2005 Jan 27;48(2):507-14. DM9EN01 RU https://pubmed.ncbi.nlm.nih.gov/15658864 DMB10GV DI DMB10GV DMB10GV DN Des-AA1,2,5-[D-Trp8,IAmp9,(NalphaMe)Thr12]SRIF DMB10GV MI TTIND6G DMB10GV MN Somatostatin receptor type 1 (SSTR1) DMB10GV MT DTT DMB10GV MA Inhibitor DMB10GV RN Somatostatin receptor 1 selective analogues: 2. N(alpha)-Methylated scan. J Med Chem. 2005 Jan 27;48(2):507-14. DMB10GV RU https://pubmed.ncbi.nlm.nih.gov/15658864 DMH0DLZ DI DMH0DLZ DMH0DLZ DN Des-AA1,2,5-[D-Trp8,IAmp9,m-I-Tyr11]Cbm-SRIF DMH0DLZ MI TTIND6G DMH0DLZ MN Somatostatin receptor type 1 (SSTR1) DMH0DLZ MT DTT DMH0DLZ MA Inhibitor DMH0DLZ RN Somatostatin receptor 1 selective analogues: 2. N(alpha)-Methylated scan. J Med Chem. 2005 Jan 27;48(2):507-14. DMH0DLZ RU https://pubmed.ncbi.nlm.nih.gov/15658864 DMH0DLZ DI DMH0DLZ DMH0DLZ DN Des-AA1,2,5-[D-Trp8,IAmp9,m-I-Tyr11]Cbm-SRIF DMH0DLZ MI TTJX3UE DMH0DLZ MN Somatostatin receptor type 3 (SSTR3) DMH0DLZ MT DTT DMH0DLZ MA Inhibitor DMH0DLZ RN Somatostatin receptor 1 selective analogues: 2. N(alpha)-Methylated scan. J Med Chem. 2005 Jan 27;48(2):507-14. DMH0DLZ RU https://pubmed.ncbi.nlm.nih.gov/15658864 DMXWF2Z DI DMXWF2Z DMXWF2Z DN Des-AA1,2,5-[D-Trp8,IAmp9,Tyr11]Cbm-SRIF DMXWF2Z MI TTIND6G DMXWF2Z MN Somatostatin receptor type 1 (SSTR1) DMXWF2Z MT DTT DMXWF2Z MA Inhibitor DMXWF2Z RN Somatostatin receptor 1 selective analogues: 2. N(alpha)-Methylated scan. J Med Chem. 2005 Jan 27;48(2):507-14. DMXWF2Z RU https://pubmed.ncbi.nlm.nih.gov/15658864 DMSXILZ DI DMSXILZ DMSXILZ DN Des-AA1,2,5-[D-Trp8,IAmp9]SRIF CH-275 DMSXILZ MI TTIND6G DMSXILZ MN Somatostatin receptor type 1 (SSTR1) DMSXILZ MT DTT DMSXILZ MA Inhibitor DMSXILZ RN Somatostatin receptor 1 selective analogues: 2. N(alpha)-Methylated scan. J Med Chem. 2005 Jan 27;48(2):507-14. DMSXILZ RU https://pubmed.ncbi.nlm.nih.gov/15658864 DMSXILZ DI DMSXILZ DMSXILZ DN Des-AA1,2,5-[D-Trp8,IAmp9]SRIF CH-275 DMSXILZ MI TTJX3UE DMSXILZ MN Somatostatin receptor type 3 (SSTR3) DMSXILZ MT DTT DMSXILZ MA Inhibitor DMSXILZ RN Somatostatin receptor 1 selective analogues: 2. N(alpha)-Methylated scan. J Med Chem. 2005 Jan 27;48(2):507-14. DMSXILZ RU https://pubmed.ncbi.nlm.nih.gov/15658864 DM7MZ2V DI DM7MZ2V DM7MZ2V DN Des-AA1,2,5-[D-Trp8,Tyr11]SRIF DM7MZ2V MI TTIND6G DM7MZ2V MN Somatostatin receptor type 1 (SSTR1) DM7MZ2V MT DTT DM7MZ2V MA Inhibitor DM7MZ2V RN Somatostatin receptor 1 selective analogues: 2. N(alpha)-Methylated scan. J Med Chem. 2005 Jan 27;48(2):507-14. DM7MZ2V RU https://pubmed.ncbi.nlm.nih.gov/15658864 DM7MZ2V DI DM7MZ2V DM7MZ2V DN Des-AA1,2,5-[D-Trp8,Tyr11]SRIF DM7MZ2V MI TTZ6T9E DM7MZ2V MN Somatostatin receptor type 2 (SSTR2) DM7MZ2V MT DTT DM7MZ2V MA Inhibitor DM7MZ2V RN Somatostatin receptor 1 selective analogues: 2. N(alpha)-Methylated scan. J Med Chem. 2005 Jan 27;48(2):507-14. DM7MZ2V RU https://pubmed.ncbi.nlm.nih.gov/15658864 DM7MZ2V DI DM7MZ2V DM7MZ2V DN Des-AA1,2,5-[D-Trp8,Tyr11]SRIF DM7MZ2V MI TTJX3UE DM7MZ2V MN Somatostatin receptor type 3 (SSTR3) DM7MZ2V MT DTT DM7MZ2V MA Inhibitor DM7MZ2V RN Somatostatin receptor 1 selective analogues: 2. N(alpha)-Methylated scan. J Med Chem. 2005 Jan 27;48(2):507-14. DM7MZ2V RU https://pubmed.ncbi.nlm.nih.gov/15658864 DM7MZ2V DI DM7MZ2V DM7MZ2V DN Des-AA1,2,5-[D-Trp8,Tyr11]SRIF DM7MZ2V MI TTAE1BR DM7MZ2V MN Somatostatin receptor type 4 (SSTR4) DM7MZ2V MT DTT DM7MZ2V MA Inhibitor DM7MZ2V RN Somatostatin receptor 1 selective analogues: 2. N(alpha)-Methylated scan. J Med Chem. 2005 Jan 27;48(2):507-14. DM7MZ2V RU https://pubmed.ncbi.nlm.nih.gov/15658864 DM7MZ2V DI DM7MZ2V DM7MZ2V DN Des-AA1,2,5-[D-Trp8,Tyr11]SRIF DM7MZ2V MI TT2BC4G DM7MZ2V MN Somatostatin receptor type 5 (SSTR5) DM7MZ2V MT DTT DM7MZ2V MA Inhibitor DM7MZ2V RN Somatostatin receptor 1 selective analogues: 2. N(alpha)-Methylated scan. J Med Chem. 2005 Jan 27;48(2):507-14. DM7MZ2V RU https://pubmed.ncbi.nlm.nih.gov/15658864 DMQRUF6 DI DMQRUF6 DMQRUF6 DN Des-AA1,2,5-[IAmp9,Tyr11]-SRIF DMQRUF6 MI TTIND6G DMQRUF6 MN Somatostatin receptor type 1 (SSTR1) DMQRUF6 MT DTT DMQRUF6 MA Inhibitor DMQRUF6 RN Somatostatin receptor 1 selective analogues: 2. N(alpha)-Methylated scan. J Med Chem. 2005 Jan 27;48(2):507-14. DMQRUF6 RU https://pubmed.ncbi.nlm.nih.gov/15658864 DMQRUF6 DI DMQRUF6 DMQRUF6 DN Des-AA1,2,5-[IAmp9,Tyr11]-SRIF DMQRUF6 MI TTAE1BR DMQRUF6 MN Somatostatin receptor type 4 (SSTR4) DMQRUF6 MT DTT DMQRUF6 MA Inhibitor DMQRUF6 RN Somatostatin receptor 1 selective analogues: 2. N(alpha)-Methylated scan. J Med Chem. 2005 Jan 27;48(2):507-14. DMQRUF6 RU https://pubmed.ncbi.nlm.nih.gov/15658864 DMPMAXI DI DMPMAXI DMPMAXI DN Des-AA1,4,5,13-[Tyr2,D-Trp8]-SRIF DMPMAXI MI TTIND6G DMPMAXI MN Somatostatin receptor type 1 (SSTR1) DMPMAXI MT DTT DMPMAXI MA Inhibitor DMPMAXI RN Somatostatin receptor 1 selective analogues: 3. Dicyclic peptides. J Med Chem. 2005 Jan 27;48(2):515-22. DMPMAXI RU https://pubmed.ncbi.nlm.nih.gov/15658865 DMPMAXI DI DMPMAXI DMPMAXI DN Des-AA1,4,5,13-[Tyr2,D-Trp8]-SRIF DMPMAXI MI TTJX3UE DMPMAXI MN Somatostatin receptor type 3 (SSTR3) DMPMAXI MT DTT DMPMAXI MA Inhibitor DMPMAXI RN Somatostatin receptor 1 selective analogues: 3. Dicyclic peptides. J Med Chem. 2005 Jan 27;48(2):515-22. DMPMAXI RU https://pubmed.ncbi.nlm.nih.gov/15658865 DMFCA05 DI DMFCA05 DMFCA05 DN Des-AA1,5-[Tyr2,D-Trp8,(NalphaMe)IAmp9]Cbm-SRIF DMFCA05 MI TTIND6G DMFCA05 MN Somatostatin receptor type 1 (SSTR1) DMFCA05 MT DTT DMFCA05 MA Inhibitor DMFCA05 RN Somatostatin receptor 1 selective analogues: 2. N(alpha)-Methylated scan. J Med Chem. 2005 Jan 27;48(2):507-14. DMFCA05 RU https://pubmed.ncbi.nlm.nih.gov/15658864 DMFCA05 DI DMFCA05 DMFCA05 DN Des-AA1,5-[Tyr2,D-Trp8,(NalphaMe)IAmp9]Cbm-SRIF DMFCA05 MI TTAE1BR DMFCA05 MN Somatostatin receptor type 4 (SSTR4) DMFCA05 MT DTT DMFCA05 MA Inhibitor DMFCA05 RN Somatostatin receptor 1 selective analogues: 2. N(alpha)-Methylated scan. J Med Chem. 2005 Jan 27;48(2):507-14. DMFCA05 RU https://pubmed.ncbi.nlm.nih.gov/15658864 DMW56NI DI DMW56NI DMW56NI DN Des-AA1,5-[Tyr2,D-Trp8,(NalphaMe)IAmp9]SRIF DMW56NI MI TTIND6G DMW56NI MN Somatostatin receptor type 1 (SSTR1) DMW56NI MT DTT DMW56NI MA Inhibitor DMW56NI RN Somatostatin receptor 1 selective analogues: 2. N(alpha)-Methylated scan. J Med Chem. 2005 Jan 27;48(2):507-14. DMW56NI RU https://pubmed.ncbi.nlm.nih.gov/15658864 DMW56NI DI DMW56NI DMW56NI DN Des-AA1,5-[Tyr2,D-Trp8,(NalphaMe)IAmp9]SRIF DMW56NI MI TTAE1BR DMW56NI MN Somatostatin receptor type 4 (SSTR4) DMW56NI MT DTT DMW56NI MA Inhibitor DMW56NI RN Somatostatin receptor 1 selective analogues: 2. N(alpha)-Methylated scan. J Med Chem. 2005 Jan 27;48(2):507-14. DMW56NI RU https://pubmed.ncbi.nlm.nih.gov/15658864 DMV8EWF DI DMV8EWF DMV8EWF DN Des-AA1,5-[Tyr2,D-Trp8,IAmp9]Cbm-SRIF DMV8EWF MI TTIND6G DMV8EWF MN Somatostatin receptor type 1 (SSTR1) DMV8EWF MT DTT DMV8EWF MA Inhibitor DMV8EWF RN Somatostatin receptor 1 selective analogues: 2. N(alpha)-Methylated scan. J Med Chem. 2005 Jan 27;48(2):507-14. DMV8EWF RU https://pubmed.ncbi.nlm.nih.gov/15658864 DMV8EWF DI DMV8EWF DMV8EWF DN Des-AA1,5-[Tyr2,D-Trp8,IAmp9]Cbm-SRIF DMV8EWF MI TTJX3UE DMV8EWF MN Somatostatin receptor type 3 (SSTR3) DMV8EWF MT DTT DMV8EWF MA Inhibitor DMV8EWF RN Somatostatin receptor 1 selective analogues: 2. N(alpha)-Methylated scan. J Med Chem. 2005 Jan 27;48(2):507-14. DMV8EWF RU https://pubmed.ncbi.nlm.nih.gov/15658864 DMLY7DC DI DMLY7DC DMLY7DC DN Des-AA1,5-[Tyr2,D-Trp8,IAmp9]SRIF CH-288 DMLY7DC MI TTIND6G DMLY7DC MN Somatostatin receptor type 1 (SSTR1) DMLY7DC MT DTT DMLY7DC MA Inhibitor DMLY7DC RN Somatostatin receptor 1 selective analogues: 3. Dicyclic peptides. J Med Chem. 2005 Jan 27;48(2):515-22. DMLY7DC RU https://pubmed.ncbi.nlm.nih.gov/15658865 DMO3CFV DI DMO3CFV DMO3CFV DN Des-AA5-[D-Trp8]SRIF DMO3CFV MI TTIND6G DMO3CFV MN Somatostatin receptor type 1 (SSTR1) DMO3CFV MT DTT DMO3CFV MA Inhibitor DMO3CFV RN Somatostatin receptor 1 selective analogues: 2. N(alpha)-Methylated scan. J Med Chem. 2005 Jan 27;48(2):507-14. DMO3CFV RU https://pubmed.ncbi.nlm.nih.gov/15658864 DMO3CFV DI DMO3CFV DMO3CFV DN Des-AA5-[D-Trp8]SRIF DMO3CFV MI TTZ6T9E DMO3CFV MN Somatostatin receptor type 2 (SSTR2) DMO3CFV MT DTT DMO3CFV MA Inhibitor DMO3CFV RN Somatostatin receptor 1 selective analogues: 2. N(alpha)-Methylated scan. J Med Chem. 2005 Jan 27;48(2):507-14. DMO3CFV RU https://pubmed.ncbi.nlm.nih.gov/15658864 DMO3CFV DI DMO3CFV DMO3CFV DN Des-AA5-[D-Trp8]SRIF DMO3CFV MI TTJX3UE DMO3CFV MN Somatostatin receptor type 3 (SSTR3) DMO3CFV MT DTT DMO3CFV MA Inhibitor DMO3CFV RN Somatostatin receptor 1 selective analogues: 2. N(alpha)-Methylated scan. J Med Chem. 2005 Jan 27;48(2):507-14. DMO3CFV RU https://pubmed.ncbi.nlm.nih.gov/15658864 DMO3CFV DI DMO3CFV DMO3CFV DN Des-AA5-[D-Trp8]SRIF DMO3CFV MI TTAE1BR DMO3CFV MN Somatostatin receptor type 4 (SSTR4) DMO3CFV MT DTT DMO3CFV MA Inhibitor DMO3CFV RN Somatostatin receptor 1 selective analogues: 2. N(alpha)-Methylated scan. J Med Chem. 2005 Jan 27;48(2):507-14. DMO3CFV RU https://pubmed.ncbi.nlm.nih.gov/15658864 DMO3CFV DI DMO3CFV DMO3CFV DN Des-AA5-[D-Trp8]SRIF DMO3CFV MI TT2BC4G DMO3CFV MN Somatostatin receptor type 5 (SSTR5) DMO3CFV MT DTT DMO3CFV MA Inhibitor DMO3CFV RN Somatostatin receptor 1 selective analogues: 2. N(alpha)-Methylated scan. J Med Chem. 2005 Jan 27;48(2):507-14. DMO3CFV RU https://pubmed.ncbi.nlm.nih.gov/15658864 DMVX9I0 DI DMVX9I0 DMVX9I0 DN Des-Arg(9)-[Leu(8)]-BK DMVX9I0 MI TTG5QIA DMVX9I0 MN B1 bradykinin receptor (BDKRB1) DMVX9I0 MT DTT DMVX9I0 MA Antagonist DMVX9I0 RN Evidence for the participation of kinins in Freund's adjuvant-induced inflammatory and nociceptive responses in kinin B1 and B2 receptor knockout mice. Neuropharmacology. 2001 Dec;41(8):1006-12. DMVX9I0 RU https://pubmed.ncbi.nlm.nih.gov/11747905 DMVX9I0 DI DMVX9I0 DMVX9I0 DN Des-Arg(9)-[Leu(8)]-BK DMVX9I0 MI TT7EFHR DMVX9I0 MN Corticotropin-releasing factor receptor 1 (CRHR1) DMVX9I0 MT DTT DMVX9I0 MA Antagonist DMVX9I0 RN A review of drug options in age-related macular degeneration therapy and potential new agents. Expert Opin Pharmacother. 2006 Dec;7(17):2355-68. DMVX9I0 RU https://pubmed.ncbi.nlm.nih.gov/17109611 DMZ5Y94 DI DMZ5Y94 DMZ5Y94 DN Des-Arg10-Kallidin DMZ5Y94 MI TTG5QIA DMZ5Y94 MN B1 bradykinin receptor (BDKRB1) DMZ5Y94 MT DTT DMZ5Y94 MA Inhibitor DMZ5Y94 RN Development of an efficient and selective radioligand for bradykinin B1 receptor occupancy studies. Bioorg Med Chem Lett. 2004 Dec 20;14(24):6045-8. DMZ5Y94 RU https://pubmed.ncbi.nlm.nih.gov/15546726 DMWO4EI DI DMWO4EI DMWO4EI DN Des-Arg10-Leu9-Kallidin DMWO4EI MI TTG5QIA DMWO4EI MN B1 bradykinin receptor (BDKRB1) DMWO4EI MT DTT DMWO4EI MA Inhibitor DMWO4EI RN Development of an efficient and selective radioligand for bradykinin B1 receptor occupancy studies. Bioorg Med Chem Lett. 2004 Dec 20;14(24):6045-8. DMWO4EI RU https://pubmed.ncbi.nlm.nih.gov/15546726 DMIKUBY DI DMIKUBY DMIKUBY DN Des-bromoaplysamine-1 DMIKUBY MI TT9JNIC DMIKUBY MN Histamine H3 receptor (H3R) DMIKUBY MT DTT DMIKUBY MA Inhibitor DMIKUBY RN Aplysamine-1 and related analogs as histamine H3 receptor antagonists. Bioorg Med Chem Lett. 2006 Feb 15;16(4):897-900. DMIKUBY RU https://pubmed.ncbi.nlm.nih.gov/16300945 DMQER8D DI DMQER8D DMQER8D DN Deschloroflavopiridol DMQER8D MI TTO0FDJ DMQER8D MN Cyclin-dependent kinase 6 (CDK6) DMQER8D MT DTT DMQER8D MA Inhibitor DMQER8D RN Pharmacological inhibitors of cyclin-dependent kinases. Trends Pharmacol Sci. 2002 Sep;23(9):417-25. DMQER8D RU https://pubmed.ncbi.nlm.nih.gov/12237154 DMQER8D DI DMQER8D DMQER8D DN Deschloroflavopiridol DMQER8D MI TT1LVF2 DMQER8D MN Cyclin-dependent kinase 9 (CDK9) DMQER8D MT DTT DMQER8D MA Binder DMQER8D RN Pharmacological inhibitors of cyclin-dependent kinases. Trends Pharmacol Sci. 2002 Sep;23(9):417-25. DMQER8D RU https://pubmed.ncbi.nlm.nih.gov/12237154 DMAB9KG DI DMAB9KG DMAB9KG DN Desclasinose Azithromycinarylalkyl Hydroxamate DMAB9KG MI TT6R7JZ DMAB9KG MN Histone deacetylase 1 (HDAC1) DMAB9KG MT DTT DMAB9KG MA Inhibitor DMAB9KG RN Non-peptide macrocyclic histone deacetylase inhibitors. J Med Chem. 2009 Jan 22;52(2):456-68. DMAB9KG RU https://pubmed.ncbi.nlm.nih.gov/19093884 DMAB9KG DI DMAB9KG DMAB9KG DN Desclasinose Azithromycinarylalkyl Hydroxamate DMAB9KG MI TTT6LFV DMAB9KG MN Histone deacetylase 8 (HDAC8) DMAB9KG MT DTT DMAB9KG MA Inhibitor DMAB9KG RN Non-peptide macrocyclic histone deacetylase inhibitors. J Med Chem. 2009 Jan 22;52(2):456-68. DMAB9KG RU https://pubmed.ncbi.nlm.nih.gov/19093884 DM47JFS DI DM47JFS DM47JFS DN Desethyl isoquine DM47JFS MI TTVG215 DM47JFS MN Debrisoquine 4-hydroxylase (CYP2D6) DM47JFS MT DTT DM47JFS MA Inhibitor DM47JFS RN Candidate selection and preclinical evaluation of N-tert-butyl isoquine (GSK369796), an affordable and effective 4-aminoquinoline antimalarial for ... J Med Chem. 2009 Mar 12;52(5):1408-15. DM47JFS RU https://pubmed.ncbi.nlm.nih.gov/19222165 DMJK0H5 DI DMJK0H5 DMJK0H5 DN DesGly-NH2,d(CH2)5[D-Tyr2,Thr4,Orn8(5/6C-Flu)]VT DMJK0H5 MI TTSCIUP DMJK0H5 MN Oxytocin receptor (OTR) DMJK0H5 MT DTT DMJK0H5 MA Inhibitor DMJK0H5 RN Synthesis and characterization of fluorescent antagonists and agonists for human oxytocin and vasopressin V(1)(a) receptors. J Med Chem. 2002 Jun 6;45(12):2579-88. DMJK0H5 RU https://pubmed.ncbi.nlm.nih.gov/12036367 DMJK0H5 DI DMJK0H5 DMJK0H5 DN DesGly-NH2,d(CH2)5[D-Tyr2,Thr4,Orn8(5/6C-Flu)]VT DMJK0H5 MI TT4TFGN DMJK0H5 MN Vasopressin V1a receptor (V1AR) DMJK0H5 MT DTT DMJK0H5 MA Inhibitor DMJK0H5 RN Synthesis and characterization of fluorescent antagonists and agonists for human oxytocin and vasopressin V(1)(a) receptors. J Med Chem. 2002 Jun 6;45(12):2579-88. DMJK0H5 RU https://pubmed.ncbi.nlm.nih.gov/12036367 DMGTAZ4 DI DMGTAZ4 DMGTAZ4 DN Des-His1[Glu9]glucagon-NH2 DMGTAZ4 MI TT9O6WS DMGTAZ4 MN Glucagon receptor (GCGR) DMGTAZ4 MT DTT DMGTAZ4 MA Inhibitor DMGTAZ4 RN Discovery and investigation of a novel class of thiophene-derived antagonists of the human glucagon receptor. Bioorg Med Chem Lett. 2005 Mar 1;15(5):1401-5. DMGTAZ4 RU https://pubmed.ncbi.nlm.nih.gov/15713396 DMB07WE DI DMB07WE DMB07WE DN Desirudine DMB07WE MI TT6L509 DMB07WE MN Coagulation factor IIa (F2) DMB07WE MT DTT DMB07WE MA Inhibitor DMB07WE RN New antithrombotic drugs (excluding plasminogen activators. Arch Mal Coeur Vaiss. 2001 Nov;94(11 Suppl):1225-32. DMB07WE RU https://pubmed.ncbi.nlm.nih.gov/11794963 DM58XJN DI DM58XJN DM58XJN DN Desmethylastemizole DM58XJN MI DERSX5P DM58XJN MN Cytochrome P450 2J2 (CYP2J2) DM58XJN MT DME DM58XJN MA Metabolism DM58XJN RN Involvement of CYP2J2 on the intestinal first-pass metabolism of antihistamine drug, astemizole. Drug Metab Dispos. 2002 Nov;30(11):1240-5. DM58XJN RU https://www.ncbi.nlm.nih.gov/pubmed/?term=12386130 DM58XJN DI DM58XJN DM58XJN DN Desmethylastemizole DM58XJN MI TTQ6VDM DM58XJN MN Voltage-gated potassium channel Kv11.1 (KCNH2) DM58XJN MT DTT DM58XJN MA Blocker DM58XJN RN Block of HERG potassium channels by the antihistamine astemizole and its metabolites desmethylastemizole and norastemizole. J Cardiovasc Electrophysiol. 1999 Jun;10(6):836-43. DM58XJN RU https://pubmed.ncbi.nlm.nih.gov/10376921 DMIESYM DI DMIESYM DMIESYM DN Desmethylclomipramine DMIESYM MI TTJXYQ6 DMIESYM MN Monoamine uptake (MA uptake) DMIESYM MT DTT DMIESYM MA Inhibitor DMIESYM RN Do alpha2-adrenoceptors play an integral role in the antinociceptive mechanism of action of antidepressant compounds Eur J Pharmacol. 1999 Aug 6;378(2):161-8. DMIESYM RU https://pubmed.ncbi.nlm.nih.gov/10478628 DMLKBNR DI DMLKBNR DMLKBNR DN DESMETHYLOLANZAPINE DMLKBNR MI TTQ6VDM DMLKBNR MN Voltage-gated potassium channel Kv11.1 (KCNH2) DMLKBNR MT DTT DMLKBNR MA Inhibitor DMLKBNR RN Side chain flexibilities in the human ether-a-go-go related gene potassium channel (hERG) together with matched-pair binding studies suggest a new ... J Med Chem. 2009 Jul 23;52(14):4266-76. DMLKBNR RU https://pubmed.ncbi.nlm.nih.gov/19534531 DMV8SUM DI DMV8SUM DMV8SUM DN Desmosterol DMV8SUM MI DEAXY04 DMV8SUM MN Delta(24)-sterol reductase (DHCR24) DMV8SUM MT DME DMV8SUM MA Metabolism DMV8SUM RN Alzheimer's disease: brain desmosterol levels. J Alzheimers Dis. 2013;33(3):881-8. DMV8SUM RU https://www.ncbi.nlm.nih.gov/pubmed/?term=23042211 DMV8SUM DI DMV8SUM DMV8SUM DN Desmosterol DMV8SUM MI TTS4UGC DMV8SUM MN Farnesoid X-activated receptor (FXR) DMV8SUM MT DTT DMV8SUM MA Agonist DMV8SUM RN Identification of farnesoid X receptor beta as a novel mammalian nuclear receptor sensing lanosterol. Mol Cell Biol. 2003 Feb;23(3):864-72. DMV8SUM RU https://pubmed.ncbi.nlm.nih.gov/12529392 DMV8SUM DI DMV8SUM DMV8SUM DN Desmosterol DMV8SUM MI TTECBXN DMV8SUM MN Oxysterols receptor LXR-alpha (NR1H3) DMV8SUM MT DTT DMV8SUM MA Agonist DMV8SUM RN Sterol intermediates from cholesterol biosynthetic pathway as liver X receptor ligands. J Biol Chem. 2006 Sep 22;281(38):27816-26. DMV8SUM RU https://pubmed.ncbi.nlm.nih.gov/16857673 DMV8SUM DI DMV8SUM DMV8SUM DN Desmosterol DMV8SUM MI TTXA6PH DMV8SUM MN Oxysterols receptor LXR-beta (NR1H2) DMV8SUM MT DTT DMV8SUM MA Agonist DMV8SUM RN Sterol intermediates from cholesterol biosynthetic pathway as liver X receptor ligands. J Biol Chem. 2006 Sep 22;281(38):27816-26. DMV8SUM RU https://pubmed.ncbi.nlm.nih.gov/16857673 DMV8SUM DI DMV8SUM DMV8SUM DN Desmosterol DMV8SUM MI DEL7GFA DMV8SUM MN Sterol Delta(7)-reductase (DHCR7) DMV8SUM MT DME DMV8SUM MA Metabolism DMV8SUM RN Inhibitors of 7-dehydrocholesterol reductase: screening of a collection of pharmacologically active compounds in Neuro2a cells. Chem Res Toxicol. 2016 May 16;29(5):892-900. DMV8SUM RU https://www.ncbi.nlm.nih.gov/pubmed/?term=27097157 DMW740T DI DMW740T DMW740T DN desulfated cholecystokinin-8 DMW740T MI TTVFO0U DMW740T MN Gastrin/cholecystokinin type B receptor (CCKBR) DMW740T MT DTT DMW740T MA Agonist DMW740T RN The human brain cholecystokinin-B/gastrin receptor. Cloning and characterization. J Biol Chem. 1993 Apr 15;268(11):8164-9. DMW740T RU https://pubmed.ncbi.nlm.nih.gov/7681836 DMFWDNJ DI DMFWDNJ DMFWDNJ DN detirelix DMFWDNJ MI TT8R70G DMFWDNJ MN Gonadotropin-releasing hormone receptor (GNRHR) DMFWDNJ MT DTT DMFWDNJ MA Modulator DMFWDNJ RN Inhibition of follicular development by a potent antagonistic analog of gonadotropin-releasing hormone (detirelix). J Clin Endocrinol Metab. 1991 Apr;72(4):927-33. DMFWDNJ RU https://www.ncbi.nlm.nih.gov/pubmed/2005220 DMPCRSY DI DMPCRSY DMPCRSY DN Detrothyronine DMPCRSY MI TTTSEPU DMPCRSY MN Thyroid hormone receptor alpha (THRA) DMPCRSY MT DTT DMPCRSY MA Inhibitor DMPCRSY RN Thyroid receptor ligands. Part 5: novel bicyclic agonist ligands selective for the thyroid hormone receptor beta. Bioorg Med Chem Lett. 2006 Mar 1;16(5):1240-4. DMPCRSY RU https://pubmed.ncbi.nlm.nih.gov/16338239 DMPCRSY DI DMPCRSY DMPCRSY DN Detrothyronine DMPCRSY MI TTGER3L DMPCRSY MN Thyroid hormone receptor beta (THRB) DMPCRSY MT DTT DMPCRSY MA Inhibitor DMPCRSY RN Thyroid receptor ligands. Part 5: novel bicyclic agonist ligands selective for the thyroid hormone receptor beta. Bioorg Med Chem Lett. 2006 Mar 1;16(5):1240-4. DMPCRSY RU https://pubmed.ncbi.nlm.nih.gov/16338239 DMD4N2F DI DMD4N2F DMD4N2F DN Devazepide DMD4N2F MI TTCG0AL DMD4N2F MN Cholecystokinin receptor type A (CCKAR) DMD4N2F MT DTT DMD4N2F MA Antagonist DMD4N2F RN Privileged structures: a useful concept for the rational design of new lead drug candidates. Mini Rev Med Chem. 2007 Nov;7(11):1108-19. DMD4N2F RU https://pubmed.ncbi.nlm.nih.gov/18045214 DM9P4JW DI DM9P4JW DM9P4JW DN Dexverapamil DM9P4JW MI DE4LYSA DM9P4JW MN Cytochrome P450 3A4 (CYP3A4) DM9P4JW MT DME DM9P4JW MA Metabolism DM9P4JW RN Integrated analysis on the physicochemical properties of dihydropyridine calcium channel blockers in grapefruit juice interactions. Curr Pharm Biotechnol. 2012 Jul;13(9):1705-17. DM9P4JW RU https://www.ncbi.nlm.nih.gov/pubmed/?term=22039822 DMR8M19 DI DMR8M19 DMR8M19 DN DFGYVAE DMR8M19 MI TTPADOQ DMR8M19 MN HMG-CoA reductase (HMGCR) DMR8M19 MT DTT DMR8M19 MA Inhibitor DMR8M19 RN Peptide fragmentation as an approach in modeling of an active peptide and designing a competitive inhibitory peptide for HMG-CoA reductase. Bioorg Med Chem. 2010 Jun 15;18(12):4300-9. DMR8M19 RU https://pubmed.ncbi.nlm.nih.gov/20494585 DMNX5VI DI DMNX5VI DMNX5VI DN D-fructose DMNX5VI MI DEA2SU9 DMNX5VI MN D-psicose 3-epimerase (DPEase) DMNX5VI MT DME DMNX5VI MA Metabolism DMNX5VI RN nan DMNX5VI RU nan DMUM84K DI DMUM84K DMUM84K DN DFU DMUM84K MI TTVKILB DMUM84K MN Prostaglandin G/H synthase 2 (COX-2) DMUM84K MT DTT DMUM84K MA Inhibitor DMUM84K RN Inhibition of cyclooxygenase-2 improves cardiac function in myocardial infarction. Biochem Biophys Res Commun. 2000 Jul 5;273(2):772-5. DMUM84K RU https://pubmed.ncbi.nlm.nih.gov/10873679 DM527XP DI DM527XP DM527XP DN D-Gluconhydroximo-1,5-Lactam DM527XP MI TTA0OSE DM527XP MN Lactase-phlorizin hydrolase (LCT) DM527XP MT DTT DM527XP MA Inhibitor DM527XP RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DM527XP RU https://pubmed.ncbi.nlm.nih.gov/10592235 DMPMYTE DI DMPMYTE DMPMYTE DN D-glucosamine-phosphate DMPMYTE MI DE8451N DMPMYTE MN Glucosamine-6-phosphate deaminase 1 (GNPDA1) DMPMYTE MT DME DMPMYTE MA Metabolism DMPMYTE RN Allosteric kinetics of the isoform 1 of human glucosamine-6-phosphate deaminase. Biochim Biophys Acta. 2011 Dec;1814(12):1846-53. DMPMYTE RU https://www.ncbi.nlm.nih.gov/pubmed/?term=21807125 DMPMYTE DI DMPMYTE DMPMYTE DN D-glucosamine-phosphate DMPMYTE MI DEPJGQB DMPMYTE MN Glucosamine-6-phosphate deaminase 2 (GNPDA2) DMPMYTE MT DME DMPMYTE MA Metabolism DMPMYTE RN Allosteric kinetics of the isoform 1 of human glucosamine-6-phosphate deaminase. Biochim Biophys Acta. 2011 Dec;1814(12):1846-53. DMPMYTE RU https://www.ncbi.nlm.nih.gov/pubmed/?term=21807125 DMMG2TO DI DMMG2TO DMMG2TO DN D-glucose DMMG2TO MI DENZGO4 DMMG2TO MN ADP-dependent glucokinase (ADPGK) DMMG2TO MT DME DMMG2TO MA Metabolism DMMG2TO RN The Structural and functional characterization of mammalian ADP-dependent glucokinase. J Biol Chem. 2016 Feb 19;291(8):3694-704. DMMG2TO RU https://www.ncbi.nlm.nih.gov/pubmed/?term=26555263 DMMG2TO DI DMMG2TO DMMG2TO DN D-glucose DMMG2TO MI DEKU5HL DMMG2TO MN Alcohol dehydrogenase (ADH) DMMG2TO MT DME DMMG2TO MA Metabolism DMMG2TO RN 1,3-Propanediol:NAD+ oxidoreductases of Lactobacillus brevis and Lactobacillus buchneri. Appl Environ Microbiol. 1992 Jun;58(6):2005-10. DMMG2TO RU https://pubmed.ncbi.nlm.nih.gov/1622279 DMMG2TO DI DMMG2TO DMMG2TO DN D-glucose DMMG2TO MI DEAMSKV DMMG2TO MN Alpha-glucosidase (aglA) DMMG2TO MT DME DMMG2TO MA Metabolism DMMG2TO RN Administration of Lactobacillus paracasei ameliorates type 2 diabetes in mice. Food Funct. 2018 Jul 17;9(7):3630-3639. DMMG2TO RU https://pubmed.ncbi.nlm.nih.gov/29961787 DMMG2TO DI DMMG2TO DMMG2TO DN D-glucose DMMG2TO MI DEDMAGE DMMG2TO MN Brain form hexokinase (HK1) DMMG2TO MT DME DMMG2TO MA Metabolism DMMG2TO RN Nonaggregating mutant of recombinant human hexokinase I exhibits wild-type kinetics and rod-like conformations in solution. Biochemistry. 1999 Jun 29;38(26):8359-66. DMMG2TO RU https://www.ncbi.nlm.nih.gov/pubmed/?term=10387081 DMMG2TO DI DMMG2TO DMMG2TO DN D-glucose DMMG2TO MI DEQUGC0 DMMG2TO MN D-Lactate dehydrogenase (ldhA) DMMG2TO MT DME DMMG2TO MA Metabolism DMMG2TO RN Presence of lactate dehydrogenase and lactate racemase in Megasphaera elsdenii grown on glucose or lactate. Appl Environ Microbiol. 1993 Jan;59(1):255-9. DMMG2TO RU https://pubmed.ncbi.nlm.nih.gov/8439152 DMMG2TO DI DMMG2TO DMMG2TO DN D-glucose DMMG2TO MI DTG3T6X DMMG2TO MN Glucose transporter type 1, erythrocyte/brain (SLC2A1) DMMG2TO MT DTP DMMG2TO MA Substrate DMMG2TO RN The SLC2 (GLUT) family of membrane transporters. Mol Aspects Med. 2013 Apr-Jun;34(2-3):121-38. DMMG2TO RU http://www.ncbi.nlm.nih.gov/pubmed/23506862 DMMG2TO DI DMMG2TO DMMG2TO DN D-glucose DMMG2TO MI DTKNH2D DMMG2TO MN Sodium/glucose cotransporter 2 (SLC5A2) DMMG2TO MT DTP DMMG2TO MA Substrate DMMG2TO RN The role of SGLT1 and GLUT2 in intestinal glucose transport and sensing. PLoS One. 2014 Feb 26;9(2):e89977. DMMG2TO RU http://www.ncbi.nlm.nih.gov/pubmed/24587162 DMPW46G DI DMPW46G DMPW46G DN D-glucose 1-phosphate DMPW46G MI DEJFMQ8 DMPW46G MN Phosphomannomutase 1 (PMM1) DMPW46G MT DME DMPW46G MA Metabolism DMPW46G RN The X-ray crystal structures of human alpha-phosphomannomutase 1 reveal the structural basis of congenital disorder of glycosylation type 1a. J Biol Chem. 2006 May 26;281(21):14918-26. DMPW46G RU https://www.ncbi.nlm.nih.gov/pubmed/?term=16540464 DMPW46G DI DMPW46G DMPW46G DN D-glucose 1-phosphate DMPW46G MI DEBRX3L DMPW46G MN Phosphomannomutase 2 (PMM2) DMPW46G MT DME DMPW46G MA Metabolism DMPW46G RN The X-ray crystal structures of human alpha-phosphomannomutase 1 reveal the structural basis of congenital disorder of glycosylation type 1a. J Biol Chem. 2006 May 26;281(21):14918-26. DMPW46G RU https://www.ncbi.nlm.nih.gov/pubmed/?term=16540464 DMPW46G DI DMPW46G DMPW46G DN D-glucose 1-phosphate DMPW46G MI DE4U39Y DMPW46G MN UDP-glucose pyrophosphorylase (UGPase) DMPW46G MT DME DMPW46G MA Metabolism DMPW46G RN The crystal structure of human UDP-glucose pyrophosphorylase reveals a latch effect that influences enzymatic activity. Biochem J. 2012 Mar 1;442(2):283-91. DMPW46G RU https://www.ncbi.nlm.nih.gov/pubmed/?term=22132858 DMNRW57 DI DMNRW57 DMNRW57 DN D-glucose 6-phosphate DMNRW57 MI DEE1B8O DMNRW57 MN Glucose-6-phosphatase beta (G6PC3) DMNRW57 MT DME DMNRW57 MA Metabolism DMNRW57 RN Identification and characterisation of a new human glucose-6-phosphatase isoform. FEBS Lett. 2003 Sep 11;551(1-3):159-64. DMNRW57 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=12965222 DM1YBTC DI DM1YBTC DM1YBTC DN D-glucuronate DM1YBTC MI DED2FW3 DM1YBTC MN Aldo-keto reductase 1A1 (AKR1A1) DM1YBTC MT DME DM1YBTC MA Metabolism DM1YBTC RN The C-terminal loop of aldehyde reductase determines the substrate and inhibitor specificity. Biochemistry. 1996 Nov 12;35(45):14276-80. DM1YBTC RU https://www.ncbi.nlm.nih.gov/pubmed/?term=8916913 DMAYPLE DI DMAYPLE DMAYPLE DN D-glyceraldehyde DMAYPLE MI DEX9ZJQ DMAYPLE MN Triokinase/FMN cyclase (TKFC) DMAYPLE MT DME DMAYPLE MA Metabolism DMAYPLE RN Bifunctional homodimeric triokinase/FMN cyclase: contribution of protein domains to the activities of the human enzyme and molecular dynamics simulation of domain movements. J Biol Chem. 2014 Apr 11;289(15):10620-36. DMAYPLE RU https://www.ncbi.nlm.nih.gov/pubmed/?term=24569995 DM7UVOD DI DM7UVOD DM7UVOD DN DH97 DM7UVOD MI TT0WAIE DM7UVOD MN Melatonin receptor type 1A (MTNR1A) DM7UVOD MT DTT DM7UVOD MA Antagonist DM7UVOD RN Comparison of the structure-activity relationships of melatonin receptor agonists and antagonists: lengthening the N-acyl side-chain has differing effects on potency on Xenopus melanophores. Naunyn Schmiedebergs Arch Pharmacol. 1998 Nov;358(5):522-8. DM7UVOD RU https://pubmed.ncbi.nlm.nih.gov/9840420 DMSN87T DI DMSN87T DMSN87T DN Dhp-c[D-Cys-Gly-Phe(pNO2)-D-Cys]NH2 DMSN87T MI TT27RFC DMSN87T MN Opioid receptor delta (OPRD1) DMSN87T MT DTT DMSN87T MA Inhibitor DMSN87T RN Replacement of the N-terminal tyrosine residue in opioid peptides with 3-(2,6-dimethyl-4-carbamoylphenyl)propanoic acid (Dcp) results in novel opio... J Med Chem. 2006 Aug 24;49(17):5382-5. DMSN87T RU https://pubmed.ncbi.nlm.nih.gov/16913729 DMSN87T DI DMSN87T DMSN87T DN Dhp-c[D-Cys-Gly-Phe(pNO2)-D-Cys]NH2 DMSN87T MI TTQW87Y DMSN87T MN Opioid receptor kappa (OPRK1) DMSN87T MT DTT DMSN87T MA Inhibitor DMSN87T RN Replacement of the N-terminal tyrosine residue in opioid peptides with 3-(2,6-dimethyl-4-carbamoylphenyl)propanoic acid (Dcp) results in novel opio... J Med Chem. 2006 Aug 24;49(17):5382-5. DMSN87T RU https://pubmed.ncbi.nlm.nih.gov/16913729 DMSN87T DI DMSN87T DMSN87T DN Dhp-c[D-Cys-Gly-Phe(pNO2)-D-Cys]NH2 DMSN87T MI TTKWM86 DMSN87T MN Opioid receptor mu (MOP) DMSN87T MT DTT DMSN87T MA Inhibitor DMSN87T RN Replacement of the N-terminal tyrosine residue in opioid peptides with 3-(2,6-dimethyl-4-carbamoylphenyl)propanoic acid (Dcp) results in novel opio... J Med Chem. 2006 Aug 24;49(17):5382-5. DMSN87T RU https://pubmed.ncbi.nlm.nih.gov/16913729 DM3DR6J DI DM3DR6J DM3DR6J DN Di(1H-indol-2-yl)methanone DM3DR6J MI TTGJCWZ DM3DR6J MN Fms-like tyrosine kinase 3 (FLT-3) DM3DR6J MT DTT DM3DR6J MA Inhibitor DM3DR6J RN Novel bis(1H-indol-2-yl)methanones as potent inhibitors of FLT3 and platelet-derived growth factor receptor tyrosine kinase. J Med Chem. 2006 Jun 1;49(11):3101-15. DM3DR6J RU https://pubmed.ncbi.nlm.nih.gov/16722630 DM3DR6J DI DM3DR6J DM3DR6J DN Di(1H-indol-2-yl)methanone DM3DR6J MI TT8FYO9 DM3DR6J MN Platelet-derived growth factor receptor alpha (PDGFRA) DM3DR6J MT DTT DM3DR6J MA Inhibitor DM3DR6J RN Novel bis(1H-indol-2-yl)methanones as potent inhibitors of FLT3 and platelet-derived growth factor receptor tyrosine kinase. J Med Chem. 2006 Jun 1;49(11):3101-15. DM3DR6J RU https://pubmed.ncbi.nlm.nih.gov/16722630 DM3DR6J DI DM3DR6J DM3DR6J DN Di(1H-indol-2-yl)methanone DM3DR6J MI TTI7421 DM3DR6J MN Platelet-derived growth factor receptor beta (PDGFRB) DM3DR6J MT DTT DM3DR6J MA Inhibitor DM3DR6J RN Novel bis(1H-indol-2-yl)methanones as potent inhibitors of FLT3 and platelet-derived growth factor receptor tyrosine kinase. J Med Chem. 2006 Jun 1;49(11):3101-15. DM3DR6J RU https://pubmed.ncbi.nlm.nih.gov/16722630 DMG21PZ DI DMG21PZ DMG21PZ DN Di(2,6-diisopropylphenol) DMG21PZ MI TTANPDJ DMG21PZ MN Carbonic anhydrase II (CA-II) DMG21PZ MT DTT DMG21PZ MA Inhibitor DMG21PZ RN Carbonic anhydrase inhibitors. Inhibition of human erythrocyte isozymes I and II with a series of antioxidant phenols. Bioorg Med Chem. 2009 Apr 15;17(8):3207-11. DMG21PZ RU https://pubmed.ncbi.nlm.nih.gov/19231207 DMZ3EML DI DMZ3EML DMZ3EML DN Di(2,6-dimethylphenol) DMZ3EML MI TTANPDJ DMZ3EML MN Carbonic anhydrase II (CA-II) DMZ3EML MT DTT DMZ3EML MA Inhibitor DMZ3EML RN Carbonic anhydrase inhibitors. Inhibition of human erythrocyte isozymes I and II with a series of antioxidant phenols. Bioorg Med Chem. 2009 Apr 15;17(8):3207-11. DMZ3EML RU https://pubmed.ncbi.nlm.nih.gov/19231207 DMO6Z02 DI DMO6Z02 DMO6Z02 DN Di(2,6-di-t-butylphenol) DMO6Z02 MI TTANPDJ DMO6Z02 MN Carbonic anhydrase II (CA-II) DMO6Z02 MT DTT DMO6Z02 MA Inhibitor DMO6Z02 RN Carbonic anhydrase inhibitors. Inhibition of human erythrocyte isozymes I and II with a series of antioxidant phenols. Bioorg Med Chem. 2009 Apr 15;17(8):3207-11. DMO6Z02 RU https://pubmed.ncbi.nlm.nih.gov/19231207 DMOCQ9J DI DMOCQ9J DMOCQ9J DN Diamide DMOCQ9J MI TTWC6MY DMOCQ9J MN Protein tyrosine phosphatase (PTP) DMOCQ9J MT DTT DMOCQ9J MA Inhibitor DMOCQ9J RN Induction of endothelial cell surface adhesion molecules by tumor necrosis factor is blocked by protein tyrosine phosphatase inhibitors: role of the nuclear transcription factor NF-kappa B. Eur J Immunol. 1997 Sep;27(9):2172-9. DMOCQ9J RU https://pubmed.ncbi.nlm.nih.gov/9341756 DM4EX8Y DI DM4EX8Y DM4EX8Y DN diamide 7 DM4EX8Y MI TT5Y4EM DM4EX8Y MN N-formyl peptide receptor (FPR1) DM4EX8Y MT DTT DM4EX8Y MA Antagonist DM4EX8Y RN Discovery of small molecule human FPR1 receptor antagonists. Bioorg Med Chem Lett. 2011 May 15;21(10):2991-7. DM4EX8Y RU https://pubmed.ncbi.nlm.nih.gov/21486695 DMDGIT6 DI DMDGIT6 DMDGIT6 DN Diaminopropyl sulfate DMDGIT6 MI TT6LDTK DMDGIT6 MN Bacterial Glutamate-1-semialdehyde aminomutase (Bact hemL) DMDGIT6 MT DTT DMDGIT6 MA Inhibitor DMDGIT6 RN Reactions of glutamate 1-semialdehyde aminomutase with R- and S-enantiomers of a novel, mechanism-based inhibitor, 2,3-diaminopropyl sulfate. Biochemistry. 2000 Mar 21;39(11):3091-6. DMDGIT6 RU https://pubmed.ncbi.nlm.nih.gov/10715130 DM14X29 DI DM14X29 DM14X29 DN diarylpropionitril DM14X29 MI TTOM3J0 DM14X29 MN Estrogen receptor beta (ESR2) DM14X29 MT DTT DM14X29 MA Agonist DM14X29 RN Estrogen receptor-beta potency-selective ligands: structure-activity relationship studies of diarylpropionitriles and their acetylene and polar analogues. J Med Chem. 2001 Nov 22;44(24):4230-51. DM14X29 RU https://pubmed.ncbi.nlm.nih.gov/11708925 DM3CQV6 DI DM3CQV6 DM3CQV6 DN DIASTEREOMER 2 DM3CQV6 MI TTNVEIR DM3CQV6 MN Prostaglandin D2 receptor (PTGDR) DM3CQV6 MT DTT DM3CQV6 MA Inhibitor DM3CQV6 RN Discovery of a potent and selective prostaglandin D2 receptor antagonist, [(3R)-4-(4-chloro-benzyl)-7-fluoro-5-(methylsulfonyl)-1,2,3,4-tetrahydroc... J Med Chem. 2007 Feb 22;50(4):794-806. DM3CQV6 RU https://pubmed.ncbi.nlm.nih.gov/17300164 DM5UFZX DI DM5UFZX DM5UFZX DN Diazaborines DM5UFZX MI TTCH81V DM5UFZX MN Bacterial NADH-dependent enoyl-ACP reductase 1 (Bact fabI1) DM5UFZX MT DTT DM5UFZX MA Inhibitor DM5UFZX RN Lipid biosynthesis as a target for antibacterial agents. Prog Lipid Res. 2001 Nov;40(6):467-97. DM5UFZX RU https://pubmed.ncbi.nlm.nih.gov/11591436 DM5UFZX DI DM5UFZX DM5UFZX DN Diazaborines DM5UFZX MI TT283NK DM5UFZX MN Bacterial NADH-dependent enoyl-ACP reductase 2 (Bact fabI2) DM5UFZX MT DTT DM5UFZX MA Inhibitor DM5UFZX RN Lipid biosynthesis as a target for antibacterial agents. Prog Lipid Res. 2001 Nov;40(6):467-97. DM5UFZX RU https://pubmed.ncbi.nlm.nih.gov/11591436 DM5UFZX DI DM5UFZX DM5UFZX DN Diazaborines DM5UFZX MI TTNSXG2 DM5UFZX MN Human immunodeficiency virus TAR RNA (HIV TAR-RNA) DM5UFZX MT DTT DM5UFZX MA Inhibitor DM5UFZX RN Neomycin B-arginine conjugate, a novel HIV-1 Tat antagonist: synthesis and anti-HIV activities. Biochemistry. 2001 Dec 25;40(51):15612-23. DM5UFZX RU https://pubmed.ncbi.nlm.nih.gov/11747436 DM5UFZX DI DM5UFZX DM5UFZX DN Diazaborines DM5UFZX MI TTNX2CS DM5UFZX MN Plasmodium Enoyl-ACP reductase (Malaria fabI) DM5UFZX MT DTT DM5UFZX MA Inhibitor DM5UFZX RN Lipid biosynthesis as a target for antibacterial agents. Prog Lipid Res. 2001 Nov;40(6):467-97. DM5UFZX RU https://pubmed.ncbi.nlm.nih.gov/11591436 DM5DPM4 DI DM5DPM4 DM5DPM4 DN Diazacholesterol DM5DPM4 MI TTTK0NH DM5DPM4 MN Delta(24)-sterol reductase (DHCR24) DM5DPM4 MT DTT DM5DPM4 MA Inhibitor DM5DPM4 RN Antilipemic drug-induced skin manifestations. Hautarzt. 1995 Feb;46(2):76-80. DM5DPM4 RU https://pubmed.ncbi.nlm.nih.gov/7706076 DM9KPHZ DI DM9KPHZ DM9KPHZ DN diBA-(5)-C4 DM9KPHZ MI TT0FC1V DM9KPHZ MN Volume regulated chloride channel (VRAC) DM9KPHZ MT DTT DM9KPHZ MA Blocker (channel blocker) DM9KPHZ RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 710). DM9KPHZ RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=710 DMOKNXE DI DMOKNXE DMOKNXE DN Dibenzo-p-dioxin-2-carboxylic acid DMOKNXE MI TTGTQHC DMOKNXE MN DNA topoisomerase I (TOP1) DMOKNXE MT DTT DMOKNXE MA Binder DMOKNXE RN Comparison of responses of DNA topoisomerase I from Candida albicans and human cells to four new agents which stimulate topoisomerase-dependent DNA nicking. FEMS Microbiol Lett. 1996 May 1;138(2-3):105-11. DMOKNXE RU https://pubmed.ncbi.nlm.nih.gov/9026436 DMEDKA3 DI DMEDKA3 DMEDKA3 DN Dibenzothiazepines DMEDKA3 MI TT6OEDT DMEDKA3 MN Cannabinoid receptor 1 (CB1) DMEDKA3 MT DTT DMEDKA3 MA Agonist DMEDKA3 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 56). DMEDKA3 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=56 DMD8TWC DI DMD8TWC DMD8TWC DN dibenzoxazepine DMD8TWC MI TTELV3W DMD8TWC MN Transformation-sensitive protein p120 (TRPA1) DMD8TWC MT DTT DMD8TWC MA Activator DMD8TWC RN Tear gasses CN, CR, and CS are potent activators of the human TRPA1 receptor. Toxicol Appl Pharmacol. 2008 Sep 1;231(2):150-6. DMD8TWC RU https://pubmed.ncbi.nlm.nih.gov/18501939 DMAYSGI DI DMAYSGI DMAYSGI DN Di-Benzyloxycarbonyl-guanidino acetylryanodine DMAYSGI MI TTU5CIX DMAYSGI MN Ryanodine receptor 1 (RYR1) DMAYSGI MT DTT DMAYSGI MA Inhibitor DMAYSGI RN Amino- and guanidinoacylryanodines: basic ryanodine esters with enhanced affinity for the sarcoplasmic reticulum Ca(2+)-release channel. J Med Chem. 1993 May 14;36(10):1319-23. DMAYSGI RU https://pubmed.ncbi.nlm.nih.gov/8388466 DM2G8ON DI DM2G8ON DM2G8ON DN Dibutyl 2,2,2-trifluoro-1-phenylethyl phosphate DM2G8ON MI TTMF541 DM2G8ON MN Liver carboxylesterase (CES1) DM2G8ON MT DTT DM2G8ON MA Inhibitor DM2G8ON RN Synthesis of organophosphates with fluorine-containing leaving groups as serine esterase inhibitors with potential for Alzheimer disease therapeutics. Bioorg Med Chem Lett. 2009 Oct 1;19(19):5528-30. DM2G8ON RU https://pubmed.ncbi.nlm.nih.gov/19717305 DMEDGKO DI DMEDGKO DMEDGKO DN Dibutyl phthalate DMEDGKO MI DE9QHP6 DMEDGKO MN Cytochrome P450 1B1 (CYP1B1) DMEDGKO MT DME DMEDGKO MA Metabolism DMEDGKO RN Inhibition of human cytochrome p450 1b1 further clarifies its role in the activation of dibenzo[a,l]pyrene in cells in culture. J Biochem Mol Toxicol. 2007;21(3):101-9. DMEDGKO RU https://www.ncbi.nlm.nih.gov/pubmed/?term=17623886 DMEDGKO DI DMEDGKO DMEDGKO DN Dibutyl phthalate DMEDGKO MI TTELV3W DMEDGKO MN Transformation-sensitive protein p120 (TRPA1) DMEDGKO MT DTT DMEDGKO MA Activator DMEDGKO RN TRPA1 and TRPV1 activation is a novel adjuvant effect mechanism in contact hypersensitivity. J Neuroimmunol. 2009 Feb 15;207(1-2):66-74. DMEDGKO RU https://pubmed.ncbi.nlm.nih.gov/19135264 DM4I5Z3 DI DM4I5Z3 DM4I5Z3 DN Dicaffeoylquinic acids DM4I5Z3 MI TT5FH9Y DM4I5Z3 MN Human immunodeficiency virus Integrase (HIV IN) DM4I5Z3 MT DTT DM4I5Z3 MA Inhibitor DM4I5Z3 RN Dicaffeoylquinic and dicaffeoyltartaric acids are selective inhibitors of human immunodeficiency virus type 1 integrase. Antimicrob Agents Chemother. 1998 Jan;42(1):140-6. DM4I5Z3 RU https://pubmed.ncbi.nlm.nih.gov/9449274 DMAV0BX DI DMAV0BX DMAV0BX DN Dicaffeoyltartaric acids DMAV0BX MI TT5FH9Y DMAV0BX MN Human immunodeficiency virus Integrase (HIV IN) DMAV0BX MT DTT DMAV0BX MA Inhibitor DMAV0BX RN Dicaffeoylquinic and dicaffeoyltartaric acids are selective inhibitors of human immunodeficiency virus type 1 integrase. Antimicrob Agents Chemother. 1998 Jan;42(1):140-6. DMAV0BX RU https://pubmed.ncbi.nlm.nih.gov/9449274 DML3HEM DI DML3HEM DML3HEM DN Dicarboxylate DML3HEM MI DTUO05P DML3HEM MN Sodium/dicarboxylate cotransporter 1 (SLC13A2) DML3HEM MT DTP DML3HEM MA Substrate DML3HEM RN Evidence for epistatic interaction between VDR and SLC13A2 genes in the pathogenesis of hypocitraturia in recurrent calcium oxalate stone formers. J Nephrol. 2017 Jun;30(3):411-418. DML3HEM RU http://www.ncbi.nlm.nih.gov/pubmed/27639591 DML3HEM DI DML3HEM DML3HEM DN Dicarboxylate DML3HEM MI DTKXTPW DML3HEM MN Sodium/dicarboxylate cotransporter 3 (SLC13A3) DML3HEM MT DTP DML3HEM MA Substrate DML3HEM RN SLC13A3 variants cause acute reversible leukoencephalopathy and -ketoglutarate accumulation. Ann Neurol. 2019 Mar;85(3):385-395. DML3HEM RU http://www.ncbi.nlm.nih.gov/pubmed/30635937 DMXGV63 DI DMXGV63 DMXGV63 DN Dichloroallyl lawsone DMXGV63 MI TT3PQ2Y DMXGV63 MN Plasmodium Dihydroorotate dehydrogenase (Malaria DHOdehase) DMXGV63 MT DTT DMXGV63 MA Inhibitor DMXGV63 RN Malarial dihydroorotate dehydrogenase. Substrate and inhibitor specificity. J Biol Chem. 2002 Nov 1;277(44):41827-34. DMXGV63 RU https://pubmed.ncbi.nlm.nih.gov/12189151 DMAU5VM DI DMAU5VM DMAU5VM DN Dichloroally-lawsone DMAU5VM MI TT3PQ2Y DMAU5VM MN Plasmodium Dihydroorotate dehydrogenase (Malaria DHOdehase) DMAU5VM MT DTT DMAU5VM MA Inhibitor DMAU5VM RN Kinetics of inhibition of human and rat dihydroorotate dehydrogenase by atovaquone, lawsone derivatives, brequinar sodium and polyporic acid. Chem Biol Interact. 2000 Jan 3;124(1):61-76. DMAU5VM RU https://pubmed.ncbi.nlm.nih.gov/10658902 DMAEI51 DI DMAEI51 DMAEI51 DN Dichloroindophenol DMAEI51 MI DE6NIY9 DMAEI51 MN Methionine synthase reductase (MTRR) DMAEI51 MT DME DMAEI51 MA Metabolism DMAEI51 RN Differences in the efficiency of reductive activation of methionine synthase and exogenous electron acceptors between the common polymorphic variants of human methionine synthase reductase. Biochemistry. 2002 Nov 12;41(45):13378-85. DMAEI51 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=12416982 DMSZ7UE DI DMSZ7UE DMSZ7UE DN Dichloroisoproterenol DMSZ7UE MI TTR6W5O DMSZ7UE MN Adrenergic receptor beta-1 (ADRB1) DMSZ7UE MT DTT DMSZ7UE MA Inhibitor DMSZ7UE RN The [(methyloxy)imino]methyl moiety as a bioisoster of aryl. A novel class of completely aliphatic beta-adrenergic receptor antagonists. J Med Chem. 1994 May 13;37(10):1518-25. DMSZ7UE RU https://pubmed.ncbi.nlm.nih.gov/7910217 DMSZ7UE DI DMSZ7UE DMSZ7UE DN Dichloroisoproterenol DMSZ7UE MI TT2CJVK DMSZ7UE MN Adrenergic receptor beta-2 (ADRB2) DMSZ7UE MT DTT DMSZ7UE MA Inhibitor DMSZ7UE RN The [(methyloxy)imino]methyl moiety as a bioisoster of aryl. A novel class of completely aliphatic beta-adrenergic receptor antagonists. J Med Chem. 1994 May 13;37(10):1518-25. DMSZ7UE RU https://pubmed.ncbi.nlm.nih.gov/7910217 DMWADLM DI DMWADLM DMWADLM DN Diclofenac glucuronide DMWADLM MI DE9EXRN DMWADLM MN Beta-glucuronidase (uidA) DMWADLM MT DME DMWADLM MA Metabolism DMWADLM RN tructure, function, and inhibition of drug reactivating human gut microbial beta-glucuronidases. Sci Rep. 2019 Jan 29;9(1):825. DMWADLM RU https://pubmed.ncbi.nlm.nih.gov/30696850 DMWADLM DI DMWADLM DMWADLM DN Diclofenac glucuronide DMWADLM MI DE7Y39R DMWADLM MN Beta-glucuronidase (uidA) DMWADLM MT DME DMWADLM MA Metabolism DMWADLM RN tructure, function, and inhibition of drug reactivating human gut microbial beta-glucuronidases. Sci Rep. 2019 Jan 29;9(1):825. DMWADLM RU https://pubmed.ncbi.nlm.nih.gov/30696850 DMWADLM DI DMWADLM DMWADLM DN Diclofenac glucuronide DMWADLM MI DECW8T2 DMWADLM MN Beta-glucuronidase (uidA) DMWADLM MT DME DMWADLM MA Metabolism DMWADLM RN tructure, function, and inhibition of drug reactivating human gut microbial beta-glucuronidases. Sci Rep. 2019 Jan 29;9(1):825. DMWADLM RU https://pubmed.ncbi.nlm.nih.gov/30696850 DMWADLM DI DMWADLM DMWADLM DN Diclofenac glucuronide DMWADLM MI DEB8PZ0 DMWADLM MN Beta-glucuronidase (uidA) DMWADLM MT DME DMWADLM MA Metabolism DMWADLM RN tructure, function, and inhibition of drug reactivating human gut microbial beta-glucuronidases. Sci Rep. 2019 Jan 29;9(1):825. DMWADLM RU https://pubmed.ncbi.nlm.nih.gov/30696850 DMO3KU5 DI DMO3KU5 DMO3KU5 DN Diclosan DMO3KU5 MI TTVTX4N DMO3KU5 MN Bacterial Fatty acid synthetase I (Bact inhA) DMO3KU5 MT DTT DMO3KU5 MA Inhibitor DMO3KU5 RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMO3KU5 RU https://pubmed.ncbi.nlm.nih.gov/17139284 DM9WU3R DI DM9WU3R DM9WU3R DN Dideazaacyclotetrahydrofolic acid DM9WU3R MI TTEXB9Z DM9WU3R MN Glycinamide ribonucleotide formyltransferase (GART) DM9WU3R MT DTT DM9WU3R MA Inhibitor DM9WU3R RN Asymmetric synthesis of inhibitors of glycinamide ribonucleotide transformylase. J Med Chem. 2008 Sep 11;51(17):5441-8. DM9WU3R RU https://pubmed.ncbi.nlm.nih.gov/18686942 DMAIOC9 DI DMAIOC9 DMAIOC9 DN Dideazafolate DMAIOC9 MI TTEXB9Z DMAIOC9 MN Glycinamide ribonucleotide formyltransferase (GART) DMAIOC9 MT DTT DMAIOC9 MA Inhibitor DMAIOC9 RN N10-substituted 5,8-dideazafolate inhibitors of glycinamide ribonucleotide transformylase. J Med Chem. 1987 Jul;30(7):1254-6. DMAIOC9 RU https://pubmed.ncbi.nlm.nih.gov/3599031 DM2FLRQ DI DM2FLRQ DM2FLRQ DN DIDODECANOYLPHLOROGLUCINOL DM2FLRQ MI TTO8QRU DM2FLRQ MN Group IIA phospholipase A2 (GIIA sPLA2) DM2FLRQ MT DTT DM2FLRQ MA Inhibitor DM2FLRQ RN Simplified YM-26734 inhibitors of secreted phospholipase A2 group IIA. Bioorg Med Chem Lett. 2008 Oct 15;18(20):5415-9. DM2FLRQ RU https://pubmed.ncbi.nlm.nih.gov/18818074 DMKSQUB DI DMKSQUB DMKSQUB DN DIDS DMKSQUB MI TTOJI4S DMKSQUB MN Calcium-dependent chloride channel anoctamin (ANO) DMKSQUB MT DTT DMKSQUB MA Blocker (channel blocker) DMKSQUB RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 708). DMKSQUB RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=708 DMKSQUB DI DMKSQUB DMKSQUB DN DIDS DMKSQUB MI TTCJRDO DMKSQUB MN Chloride channel protein 6 (ClC-6) DMKSQUB MT DTT DMKSQUB MA Blocker (channel blocker) DMKSQUB RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 705). DMKSQUB RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=705 DMKSQUB DI DMKSQUB DMKSQUB DN DIDS DMKSQUB MI TTST1AJ DMKSQUB MN Chloride channel protein 7 (ClC-7) DMKSQUB MT DTT DMKSQUB MA Blocker (channel blocker) DMKSQUB RN The G215R mutation in the Cl-/H+-antiporter ClC-7 found in ADO II osteopetrosis does not abolish function but causes a severe trafficking defect. PLoS One. 2010 Sep 7;5(9):e12585. DMKSQUB RU https://pubmed.ncbi.nlm.nih.gov/20830208 DMKSQUB DI DMKSQUB DMKSQUB DN DIDS DMKSQUB MI TT823N1 DMKSQUB MN Chloride channel protein ClC-Ka (ClC-K1) DMKSQUB MT DTT DMKSQUB MA Blocker (channel blocker) DMKSQUB RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 700). DMKSQUB RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=700 DMKSQUB DI DMKSQUB DMKSQUB DN DIDS DMKSQUB MI TTR68GQ DMKSQUB MN Chloride channel protein ClC-Kb (ClC-K2) DMKSQUB MT DTT DMKSQUB MA Blocker (channel blocker) DMKSQUB RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 701). DMKSQUB RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=701 DMKSQUB DI DMKSQUB DMKSQUB DN DIDS DMKSQUB MI TT0FC1V DMKSQUB MN Volume regulated chloride channel (VRAC) DMKSQUB MT DTT DMKSQUB MA Blocker (channel blocker) DMKSQUB RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 710). DMKSQUB RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=710 DMBCK4G DI DMBCK4G DMBCK4G DN DIECKOL DMBCK4G MI TT8JRS7 DMBCK4G MN Beta-secretase (BACE) DMBCK4G MT DTT DMBCK4G MA Inhibitor DMBCK4G RN Molecular docking studies of phlorotannins from Eisenia bicyclis with BACE1 inhibitory activity. Bioorg Med Chem Lett. 2010 Jun 1;20(11):3211-5. DMBCK4G RU https://pubmed.ncbi.nlm.nih.gov/20462757 DMK7QXA DI DMK7QXA DMK7QXA DN DIETHOXYFLOURESCEIN DMK7QXA MI TTXV4FI DMK7QXA MN Albendazole monooxygenase (CYP3A4) DMK7QXA MT DTT DMK7QXA MA Inhibitor DMK7QXA RN Exploration of the amine terminus in a novel series of 1,2,4-triazolo-3-yl-azabicyclo[3.1.0]hexanes as selective dopamine D3 receptor antagonists. J Med Chem. 2010 Oct 14;53(19):7129-39. DMK7QXA RU https://pubmed.ncbi.nlm.nih.gov/20839775 DM7YHBR DI DM7YHBR DM7YHBR DN Diethyl 2-((biphenyl-3-ylamino)methylene)malonate DM7YHBR MI TT3PQ2Y DM7YHBR MN Plasmodium Dihydroorotate dehydrogenase (Malaria DHOdehase) DM7YHBR MT DTT DM7YHBR MA Inhibitor DM7YHBR RN Design and synthesis of potent inhibitors of the malaria parasite dihydroorotate dehydrogenase. J Med Chem. 2007 Jan 25;50(2):186-91. DM7YHBR RU https://pubmed.ncbi.nlm.nih.gov/17228860 DMDJ9QA DI DMDJ9QA DMDJ9QA DN Diethyl 2,2,2-trifluoro-1-phenylethyl phosphate DMDJ9QA MI TTMF541 DMDJ9QA MN Liver carboxylesterase (CES1) DMDJ9QA MT DTT DMDJ9QA MA Inhibitor DMDJ9QA RN Synthesis of organophosphates with fluorine-containing leaving groups as serine esterase inhibitors with potential for Alzheimer disease therapeutics. Bioorg Med Chem Lett. 2009 Oct 1;19(19):5528-30. DMDJ9QA RU https://pubmed.ncbi.nlm.nih.gov/19717305 DMM4QFL DI DMM4QFL DMM4QFL DN Diethylphosphono Group DMM4QFL MI TTEB0GD DMM4QFL MN Cholinesterase (BCHE) DMM4QFL MT DTT DMM4QFL MA Inhibitor DMM4QFL RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMM4QFL RU https://pubmed.ncbi.nlm.nih.gov/17139284 DM8AZQ3 DI DM8AZQ3 DM8AZQ3 DN difluoroagomelatine DM8AZQ3 MI TT0WAIE DM8AZQ3 MN Melatonin receptor type 1A (MTNR1A) DM8AZQ3 MT DTT DM8AZQ3 MA Agonist DM8AZQ3 RN Design, synthesis and pharmacological evaluation of new series of naphthalenic analogues as melatoninergic (MT1/MT2) and serotoninergic 5-HT2C dual ligands (I). Eur J Med Chem. 2012 Mar;49:310-23. DM8AZQ3 RU https://pubmed.ncbi.nlm.nih.gov/22301214 DM8ABD6 DI DM8ABD6 DM8ABD6 DN Difluorobenztropine DM8ABD6 MI TTVBI8W DM8ABD6 MN Dopamine transporter (DAT) DM8ABD6 MT DTT DM8ABD6 MA Inhibitor DM8ABD6 RN Structure-activity relationship studies on a novel series of (S)-2beta-substituted 3alpha-[bis(4-fluoro- or 4-chlorophenyl)methoxy]tropane analogue... J Med Chem. 2006 Oct 19;49(21):6391-9. DM8ABD6 RU https://pubmed.ncbi.nlm.nih.gov/17034144 DM8ABD6 DI DM8ABD6 DM8ABD6 DN Difluorobenztropine DM8ABD6 MI TTZ9SOR DM8ABD6 MN Muscarinic acetylcholine receptor M1 (CHRM1) DM8ABD6 MT DTT DM8ABD6 MA Inhibitor DM8ABD6 RN Structure-activity relationship studies on a novel series of (S)-2beta-substituted 3alpha-[bis(4-fluoro- or 4-chlorophenyl)methoxy]tropane analogue... J Med Chem. 2006 Oct 19;49(21):6391-9. DM8ABD6 RU https://pubmed.ncbi.nlm.nih.gov/17034144 DM8ABD6 DI DM8ABD6 DM8ABD6 DN Difluorobenztropine DM8ABD6 MI TTAWNKZ DM8ABD6 MN Norepinephrine transporter (NET) DM8ABD6 MT DTT DM8ABD6 MA Inhibitor DM8ABD6 RN Structure-activity relationship studies on a novel series of (S)-2beta-substituted 3alpha-[bis(4-fluoro- or 4-chlorophenyl)methoxy]tropane analogue... J Med Chem. 2006 Oct 19;49(21):6391-9. DM8ABD6 RU https://pubmed.ncbi.nlm.nih.gov/17034144 DM8ABD6 DI DM8ABD6 DM8ABD6 DN Difluorobenztropine DM8ABD6 MI TT3ROYC DM8ABD6 MN Serotonin transporter (SERT) DM8ABD6 MT DTT DM8ABD6 MA Inhibitor DM8ABD6 RN Structure-activity relationship studies on a novel series of (S)-2beta-substituted 3alpha-[bis(4-fluoro- or 4-chlorophenyl)methoxy]tropane analogue... J Med Chem. 2006 Oct 19;49(21):6391-9. DM8ABD6 RU https://pubmed.ncbi.nlm.nih.gov/17034144 DM8TG41 DI DM8TG41 DM8TG41 DN Difluoromethionine DM8TG41 MI TTOJ46K DM8TG41 MN Streptococcus Methionyl-tRNA synthetase (Stre-coc metG) DM8TG41 MT DTT DM8TG41 MA Inhibitor DM8TG41 RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DM8TG41 RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMXK8BH DI DMXK8BH DMXK8BH DN digeranyl bisphosphonate DMXK8BH MI TTIKWV4 DMXK8BH MN Geranyltranstransferase (FDPS) DMXK8BH MT DTT DMXK8BH MA Inhibitor DMXK8BH RN Inhibition of geranylgeranyl diphosphate synthase by bisphosphonates: a crystallographic and computational investigation. J Med Chem. 2008 Sep 25;51(18):5594-607. DMXK8BH RU https://pubmed.ncbi.nlm.nih.gov/18800762 DM5AOFW DI DM5AOFW DM5AOFW DN Digitoxigenin DM5AOFW MI TTWK8D0 DM5AOFW MN Sodium pump subunit alpha-1 (ATP1A1) DM5AOFW MT DTT DM5AOFW MA Inhibitor DM5AOFW RN 17beta-O-Aminoalkyloximes of 5beta-androstane-3beta,14beta-diol with digitalis-like activity: synthesis, cardiotonic activity, structure-activity r... J Med Chem. 2000 Jun 15;43(12):2332-49. DM5AOFW RU https://pubmed.ncbi.nlm.nih.gov/10882359 DMBAY7P DI DMBAY7P DMBAY7P DN Diheptan-3-yl 5-(hydroxymethyl)isophthalate DMBAY7P MI TT7A1BO DMBAY7P MN PKC-delta messenger RNA (PRKCD mRNA) DMBAY7P MT DTT DMBAY7P MA Inhibitor DMBAY7P RN Design, synthesis, and biological activity of isophthalic acid derivatives targeted to the C1 domain of protein kinase C. J Med Chem. 2009 Jul 9;52(13):3969-81. DMBAY7P RU https://pubmed.ncbi.nlm.nih.gov/19438240 DMBAY7P DI DMBAY7P DMBAY7P DN Diheptan-3-yl 5-(hydroxymethyl)isophthalate DMBAY7P MI TTFJ8Q1 DMBAY7P MN Protein kinase C alpha (PRKCA) DMBAY7P MT DTT DMBAY7P MA Inhibitor DMBAY7P RN Design, synthesis, and biological activity of isophthalic acid derivatives targeted to the C1 domain of protein kinase C. J Med Chem. 2009 Jul 9;52(13):3969-81. DMBAY7P RU https://pubmed.ncbi.nlm.nih.gov/19438240 DM8TBQ9 DI DM8TBQ9 DM8TBQ9 DN Dihexan-3-yl 5-(hydroxymethyl)isophthalate DM8TBQ9 MI TT7A1BO DM8TBQ9 MN PKC-delta messenger RNA (PRKCD mRNA) DM8TBQ9 MT DTT DM8TBQ9 MA Inhibitor DM8TBQ9 RN Design, synthesis, and biological activity of isophthalic acid derivatives targeted to the C1 domain of protein kinase C. J Med Chem. 2009 Jul 9;52(13):3969-81. DM8TBQ9 RU https://pubmed.ncbi.nlm.nih.gov/19438240 DM8TBQ9 DI DM8TBQ9 DM8TBQ9 DN Dihexan-3-yl 5-(hydroxymethyl)isophthalate DM8TBQ9 MI TTFJ8Q1 DM8TBQ9 MN Protein kinase C alpha (PRKCA) DM8TBQ9 MT DTT DM8TBQ9 MA Inhibitor DM8TBQ9 RN Design, synthesis, and biological activity of isophthalic acid derivatives targeted to the C1 domain of protein kinase C. J Med Chem. 2009 Jul 9;52(13):3969-81. DM8TBQ9 RU https://pubmed.ncbi.nlm.nih.gov/19438240 DMW1ALX DI DMW1ALX DMW1ALX DN DIHYDROAKUAMMINE DMW1ALX MI TTKWM86 DMW1ALX MN Opioid receptor mu (MOP) DMW1ALX MT DTT DMW1ALX MA Inhibitor DMW1ALX RN Akuammine and dihydroakuammine, two indolomonoterpene alkaloids displaying affinity for opioid receptors. J Nat Prod. 1992 Mar;55(3):380-4. DMW1ALX RU https://pubmed.ncbi.nlm.nih.gov/1317407 DMS4U68 DI DMS4U68 DMS4U68 DN dihydrocarveol DMS4U68 MI TT946IA DMS4U68 MN Transient receptor potential cation channel V3 (TRPV3) DMS4U68 MT DTT DMS4U68 MA Activator DMS4U68 RN Monoterpenoid agonists of TRPV3. Br J Pharmacol. 2007 Jun;151(4):530-40. DMS4U68 RU https://pubmed.ncbi.nlm.nih.gov/17420775 DMGLX1R DI DMGLX1R DMGLX1R DN Dihydrocoumarin DMGLX1R MI DESDN74 DMGLX1R MN Serum paraoxonase/arylesterase 1 (PON1) DMGLX1R MT DME DMGLX1R MA Metabolism DMGLX1R RN Human serum paraoxonase (PON1) isozymes Q and R hydrolyze lactones and cyclic carbonate esters. Drug Metab Dispos. 2000 Nov;28(11):1335-42. DMGLX1R RU https://www.ncbi.nlm.nih.gov/pubmed/?term=11038162 DMZL7R6 DI DMZL7R6 DMZL7R6 DN DIHYDROCUBEBIN DMZL7R6 MI TTXV4FI DMZL7R6 MN Albendazole monooxygenase (CYP3A4) DMZL7R6 MT DTT DMZL7R6 MA Inhibitor DMZL7R6 RN Potent CYP3A4 inhibitory constituents of Piper cubeba. J Nat Prod. 2005 Jan;68(1):64-8. DMZL7R6 RU https://pubmed.ncbi.nlm.nih.gov/15679319 DMZL7R6 DI DMZL7R6 DMZL7R6 DN DIHYDROCUBEBIN DMZL7R6 MI TTVG215 DMZL7R6 MN Debrisoquine 4-hydroxylase (CYP2D6) DMZL7R6 MT DTT DMZL7R6 MA Inhibitor DMZL7R6 RN Potent CYP3A4 inhibitory constituents of Piper cubeba. J Nat Prod. 2005 Jan;68(1):64-8. DMZL7R6 RU https://pubmed.ncbi.nlm.nih.gov/15679319 DMDW2NL DI DMDW2NL DMDW2NL DN dihydroergocryptine DMDW2NL MI TT0K1SC DMDW2NL MN 5-HT 2B receptor (HTR2B) DMDW2NL MT DTT DMDW2NL MA Agonist DMDW2NL RN Structural features for functional selectivity at serotonin receptors. Science. 2013 May 3;340(6132):615-9. DMDW2NL RU https://pubmed.ncbi.nlm.nih.gov/23519215 DMDW2NL DI DMDW2NL DMDW2NL DN dihydroergocryptine DMDW2NL MI TTO9X1H DMDW2NL MN 5-HT 7 receptor (HTR7) DMDW2NL MT DTT DMDW2NL MA Antagonist DMDW2NL RN Molecular cloning of a mammalian serotonin receptor that activates adenylate cyclase. Mol Pharmacol. 1993 Aug;44(2):229-36. DMDW2NL RU https://pubmed.ncbi.nlm.nih.gov/8394987 DM1BDM8 DI DM1BDM8 DM1BDM8 DN Dihydrofolic Acid DM1BDM8 MI TT9SL3Q DM1BDM8 MN Polypeptide deformylase (PDF) DM1BDM8 MT DTT DM1BDM8 MA Inhibitor DM1BDM8 RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DM1BDM8 RU https://pubmed.ncbi.nlm.nih.gov/17139284 DM73OTF DI DM73OTF DM73OTF DN DIHYDROKAEMPFEROL DM73OTF MI TT7RJY8 DM73OTF MN Xanthine dehydrogenase/oxidase (XDH) DM73OTF MT DTT DM73OTF MA Inhibitor DM73OTF RN Inhibition of cow's milk xanthine oxidase by flavonoids. J Nat Prod. 1988 Mar-Apr;51(2):345-8. DM73OTF RU https://pubmed.ncbi.nlm.nih.gov/3379415 DM9NO6F DI DM9NO6F DM9NO6F DN DIHYDROKAINATE DM9NO6F MI TT0MYE2 DM9NO6F MN Glutamate receptor ionotropic kainate 1 (GRIK1) DM9NO6F MT DTT DM9NO6F MA Inhibitor DM9NO6F RN Chemo-enzymatic synthesis of (2S,4R)-2-amino-4-(3-(2,2-diphenylethylamino)-3-oxopropyl)pentanedioic acid: a novel selective inhibitor of human exci... J Med Chem. 2008 Jul 24;51(14):4085-92. DM9NO6F RU https://pubmed.ncbi.nlm.nih.gov/18578477 DMG0PXI DI DMG0PXI DMG0PXI DN Dihydrolanosterol DMG0PXI MI DEZNP5G DMG0PXI MN Cytochrome P450 51B1 (cyp51) DMG0PXI MT DME DMG0PXI MA Metabolism DMG0PXI RN Function, essentiality, and expression of cytochrome P450 enzymes and their cognate redox partners in Mycobacterium tuberculosis: are they drug targets? Appl Microbiol Biotechnol. 2019 May;103(9):3597-3614. DMG0PXI RU https://pubmed.ncbi.nlm.nih.gov/30810776 DMG0PXI DI DMG0PXI DMG0PXI DN Dihydrolanosterol DMG0PXI MI DEVSF75 DMG0PXI MN Cytochrome P450 monooxygenase 51A (cyp51A) DMG0PXI MT DME DMG0PXI MA Metabolism DMG0PXI RN nan DMG0PXI RU nan DM4TR0D DI DM4TR0D DM4TR0D DN Dihydromorphine DM4TR0D MI TT21AKM DM4TR0D MN Corticotropin-lipotropin (POMC) DM4TR0D MT DTT DM4TR0D MA Agonist DM4TR0D RN Opiate receptor binding properties of morphine-, dihydromorphine-, and codeine 6-O-sulfate ester congeners. Bioorg Med Chem Lett. 2006 Aug 15;16(16):4291-5. DM4TR0D RU https://pubmed.ncbi.nlm.nih.gov/16777416 DM4TR0D DI DM4TR0D DM4TR0D DN Dihydromorphine DM4TR0D MI TT27RFC DM4TR0D MN Opioid receptor delta (OPRD1) DM4TR0D MT DTT DM4TR0D MA Agonist DM4TR0D RN Opiate receptor binding properties of morphine-, dihydromorphine-, and codeine 6-O-sulfate ester congeners. Bioorg Med Chem Lett. 2006 Aug 15;16(16):4291-5. DM4TR0D RU https://pubmed.ncbi.nlm.nih.gov/16777416 DM4TR0D DI DM4TR0D DM4TR0D DN Dihydromorphine DM4TR0D MI TTQW87Y DM4TR0D MN Opioid receptor kappa (OPRK1) DM4TR0D MT DTT DM4TR0D MA Agonist DM4TR0D RN Opiate receptor binding properties of morphine-, dihydromorphine-, and codeine 6-O-sulfate ester congeners. Bioorg Med Chem Lett. 2006 Aug 15;16(16):4291-5. DM4TR0D RU https://pubmed.ncbi.nlm.nih.gov/16777416 DM4TR0D DI DM4TR0D DM4TR0D DN Dihydromorphine DM4TR0D MI TTKWM86 DM4TR0D MN Opioid receptor mu (MOP) DM4TR0D MT DTT DM4TR0D MA Agonist DM4TR0D RN Opiate receptor binding properties of morphine-, dihydromorphine-, and codeine 6-O-sulfate ester congeners. Bioorg Med Chem Lett. 2006 Aug 15;16(16):4291-5. DM4TR0D RU https://pubmed.ncbi.nlm.nih.gov/16777416 DM76BGZ DI DM76BGZ DM76BGZ DN Dihydroorotate DM76BGZ MI TT09NOX DM76BGZ MN Plasmodium Dihydroorotase (Malaria dho) DM76BGZ MT DTT DM76BGZ MA Inhibitor DM76BGZ RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DM76BGZ RU https://pubmed.ncbi.nlm.nih.gov/17139284 DM76BGZ DI DM76BGZ DM76BGZ DN Dihydroorotate DM76BGZ MI TT3PQ2Y DM76BGZ MN Plasmodium Dihydroorotate dehydrogenase (Malaria DHOdehase) DM76BGZ MT DTT DM76BGZ MA Inhibitor DM76BGZ RN Structure-activity relationships of pyrimidines as dihydroorotate dehydrogenase inhibitors. Biochem Pharmacol. 1988 Oct 15;37(20):3807-16. DM76BGZ RU https://pubmed.ncbi.nlm.nih.gov/2847745 DM0W64U DI DM0W64U DM0W64U DN Dihydropyridines DM0W64U MI TTXHYV6 DM0W64U MN Voltage-gated L-type calcium channel (L-CaC) DM0W64U MT DTT DM0W64U MA Blocker DM0W64U RN Pharmacology of N-type Ca2+ channels distributed in cardiovascular system (Review). Int J Mol Med. 1999 May;3(5):455-66. DM0W64U RU https://pubmed.ncbi.nlm.nih.gov/10202175 DMYSPMH DI DMYSPMH DMYSPMH DN Dihydropyrone DMYSPMH MI TT84ETX DMYSPMH MN Human immunodeficiency virus Reverse transcriptase (HIV RT) DMYSPMH MT DTT DMYSPMH MA Inhibitor DMYSPMH RN Emerging antiviral drugs. Expert Opin Emerg Drugs. 2008 Sep;13(3):393-416. DMYSPMH RU https://pubmed.ncbi.nlm.nih.gov/18764719 DM9UK6D DI DM9UK6D DM9UK6D DN Dihydro-quinolinone DM9UK6D MI TTQBR95 DM9UK6D MN Stress-activated protein kinase 2a (p38 alpha) DM9UK6D MT DTT DM9UK6D MA Inhibitor DM9UK6D RN In silico search for multi-target anti-inflammatories in Chinese herbs and formulas. Bioorg Med Chem. 2010 Mar 15;18(6):2204-2218. DM9UK6D RU https://pubmed.ncbi.nlm.nih.gov/20188577 DM70OIC DI DM70OIC DM70OIC DN DIHYDRORALOXIFENE DM70OIC MI TTZAYWL DM70OIC MN Estrogen receptor (ESR) DM70OIC MT DTT DM70OIC MA Inhibitor DM70OIC RN Synthesis and biological activity of trans-2,3-dihydroraloxifene. Bioorg Med Chem Lett. 1999 Apr 19;9(8):1137-40. DM70OIC RU https://pubmed.ncbi.nlm.nih.gov/10328300 DM70OIC DI DM70OIC DM70OIC DN DIHYDRORALOXIFENE DM70OIC MI TTOM3J0 DM70OIC MN Estrogen receptor beta (ESR2) DM70OIC MT DTT DM70OIC MA Inhibitor DM70OIC RN Synthesis and biological activity of trans-2,3-dihydroraloxifene. Bioorg Med Chem Lett. 1999 Apr 19;9(8):1137-40. DM70OIC RU https://pubmed.ncbi.nlm.nih.gov/10328300 DM58KHY DI DM58KHY DM58KHY DN dihydrosphingosine-1-phosphate DM58KHY MI TT2D5VM DM58KHY MN G-protein coupled receptor 63 (GPR63) DM58KHY MT DTT DM58KHY MA Agonist DM58KHY RN Sphingosine 1-phosphate and dioleoylphosphatidic acid are low affinity agonists for the orphan receptor GPR63. Cell Signal. 2003 Apr;15(4):435-46. DM58KHY RU https://pubmed.ncbi.nlm.nih.gov/12618218 DM58KHY DI DM58KHY DM58KHY DN dihydrosphingosine-1-phosphate DM58KHY MI TTZ8C5Q DM58KHY MN Sphingosine-1-phosphate receptor 4 (S1PR4) DM58KHY MT DTT DM58KHY MA Agonist DM58KHY RN Phytosphingosine 1-phosphate: a high affinity ligand for the S1P(4)/Edg-6 receptor. Biochem Biophys Res Commun. 2002 Sep 27;297(3):600-6. DM58KHY RU https://pubmed.ncbi.nlm.nih.gov/12270137 DMPDQSV DI DMPDQSV DMPDQSV DN Dihydrostreptomycin DMPDQSV MI DE4LYSA DMPDQSV MN Cytochrome P450 3A4 (CYP3A4) DMPDQSV MT DME DMPDQSV MA Metabolism DMPDQSV RN Troglitazone induces CYP3A4 activity leading to falsely abnormal dexamethasone suppression test. J Clin Endocrinol Metab. 2003 Jul;88(7):3113-6. DMPDQSV RU https://www.ncbi.nlm.nih.gov/pubmed/?term=12843151 DMFKWRM DI DMFKWRM DMFKWRM DN DIHYDROXANTHOHUMOL DMFKWRM MI TTG5QB7 DMFKWRM MN Calpain-2 (CAPN2) DMFKWRM MT DTT DMFKWRM MA Inhibitor DMFKWRM RN In silico identification and biochemical evaluation of novel inhibitors of NRH:quinone oxidoreductase 2 (NQO2). Bioorg Med Chem Lett. 2010 Dec 15;20(24):7331-6. DMFKWRM RU https://pubmed.ncbi.nlm.nih.gov/21074425 DME4NH1 DI DME4NH1 DME4NH1 DN Di-imidazole lexitropsin DME4NH1 MI TTOVXHF DME4NH1 MN Human Deoxyribonucleic acid minor groove (hDNA min) DME4NH1 MT DTT DME4NH1 MA Binder (minor groove binder) DME4NH1 RN Defining GC-specificity in the minor groove: side-by-side binding of the di-imidazole lexitropsin to C-A-T-G-G-C-C-A-T-G. Structure. 1997 Aug 15;5(8):1033-46. DME4NH1 RU https://pubmed.ncbi.nlm.nih.gov/9309219 DM917FE DI DM917FE DM917FE DN Diiodo-l-thyronine DM917FE MI DEYWLRK DM917FE MN Sulfotransferase 1A1 (SULT1A1) DM917FE MT DME DM917FE MA Metabolism DM917FE RN Characterization of human liver thermostable phenol sulfotransferase (SULT1A1) allozymes with 3,3',5-triiodothyronine as the substrate. J Endocrinol. 2001 Dec;171(3):525-32. DM917FE RU https://www.ncbi.nlm.nih.gov/pubmed/?term=11739018 DMNR439 DI DMNR439 DMNR439 DN Diisopropyl 1-mercaptopropylphosphonate DMNR439 MI TTHI19T DMNR439 MN Staphylococcus Beta-lactamase (Stap-coc blaZ) DMNR439 MT DTT DMNR439 MA Inhibitor DMNR439 RN Mercaptophosphonate compounds as broad-spectrum inhibitors of the metallo-beta-lactamases. J Med Chem. 2010 Jul 8;53(13):4862-76. DMNR439 RU https://pubmed.ncbi.nlm.nih.gov/20527888 DMVFJAH DI DMVFJAH DMVFJAH DN Diisopropyl 2-(sulfanylmethyl)phenylphosphonate DMVFJAH MI TTHI19T DMVFJAH MN Staphylococcus Beta-lactamase (Stap-coc blaZ) DMVFJAH MT DTT DMVFJAH MA Inhibitor DMVFJAH RN Mercaptophosphonate compounds as broad-spectrum inhibitors of the metallo-beta-lactamases. J Med Chem. 2010 Jul 8;53(13):4862-76. DMVFJAH RU https://pubmed.ncbi.nlm.nih.gov/20527888 DMHKE3M DI DMHKE3M DMHKE3M DN Diisopropyl mercapto(phenyl)methylphosphonate DMHKE3M MI TTHI19T DMHKE3M MN Staphylococcus Beta-lactamase (Stap-coc blaZ) DMHKE3M MT DTT DMHKE3M MA Inhibitor DMHKE3M RN Mercaptophosphonate compounds as broad-spectrum inhibitors of the metallo-beta-lactamases. J Med Chem. 2010 Jul 8;53(13):4862-76. DMHKE3M RU https://pubmed.ncbi.nlm.nih.gov/20527888 DMND2AS DI DMND2AS DMND2AS DN Diisopropylphosphono Group DMND2AS MI TTDIGC1 DMND2AS MN Dipeptidyl peptidase 4 (DPP-4) DMND2AS MT DTT DMND2AS MA Inhibitor DMND2AS RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMND2AS RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMPKQER DI DMPKQER DMPKQER DN Diketonitrile DMPKQER MI TT8DSFC DMPKQER MN Hydroxyphenylpyruvate dioxygenase (HPD) DMPKQER MT DTT DMPKQER MA Inhibitor DMPKQER RN 4-Hydroxyphenylpyruvate dioxygenase as a drug discovery target. Drug News Perspect. 2003 Oct;16(8):493-6. DMPKQER RU https://pubmed.ncbi.nlm.nih.gov/14668946 DMOD5Y0 DI DMOD5Y0 DMOD5Y0 DN Dilazep DMOD5Y0 MI TTLXAKE DMOD5Y0 MN Solute carrier family 29 member 1 (SLC29A1) DMOD5Y0 MT DTT DMOD5Y0 MA Inhibitor DMOD5Y0 RN Residues Met89 and Ser160 in the human equilibrative nucleoside transporter 1 affect its affinity for adenosine, guanosine, S6-(4-nitrobenzyl)-merc... Mol Pharmacol. 2005 Mar;67(3):837-44. DMOD5Y0 RU https://pubmed.ncbi.nlm.nih.gov/15557207 DMA4NI2 DI DMA4NI2 DMA4NI2 DN Dimaprit DMA4NI2 MI TTQHJ1K DMA4NI2 MN Histamine H2 receptor (H2R) DMA4NI2 MT DTT DMA4NI2 MA Agonist DMA4NI2 RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015 DMA4NI2 RU https://www.accessdata.fda.gov/scripts/cder/drugsatfda/ DMV8ZQG DI DMV8ZQG DMV8ZQG DN DIMEBOLIN DMV8ZQG MI TTJS8PY DMV8ZQG MN 5-HT 6 receptor (HTR6) DMV8ZQG MT DTT DMV8ZQG MA Inhibitor DMV8ZQG RN 8-Sulfonyl-substituted tetrahydro-1H-pyrido[4,3-b]indoles as 5-HT6 receptor antagonists. Eur J Med Chem. 2010 Feb;45(2):782-9. DMV8ZQG RU https://pubmed.ncbi.nlm.nih.gov/19939513 DMV8ZQG DI DMV8ZQG DMV8ZQG DN DIMEBOLIN DMV8ZQG MI TTTIBOJ DMV8ZQG MN Histamine H1 receptor (H1R) DMV8ZQG MT DTT DMV8ZQG MA Inhibitor DMV8ZQG RN Synthesis and biological activity of 5-styryl and 5-phenethyl-substituted 2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indoles. Bioorg Med Chem Lett. 2010 Jan 1;20(1):78-82. DMV8ZQG RU https://pubmed.ncbi.nlm.nih.gov/19945877 DM2Q3CL DI DM2Q3CL DM2Q3CL DN Dimemorfan DM2Q3CL MI TT5TPI6 DM2Q3CL MN Opioid receptor sigma 1 (OPRS1) DM2Q3CL MT DTT DM2Q3CL MA Agonist DM2Q3CL RN Dimemorfan protects rats against ischemic stroke through activation of sigma-1 receptor-mediated mechanisms by decreasing glutamate accumulation. J Neurochem. 2008 Jan;104(2):558-72. DM2Q3CL RU https://pubmed.ncbi.nlm.nih.gov/18173806 DMRMHE8 DI DMRMHE8 DMRMHE8 DN Dimepheptanol DMRMHE8 MI TT27RFC DMRMHE8 MN Opioid receptor delta (OPRD1) DMRMHE8 MT DTT DMRMHE8 MA Inhibitor DMRMHE8 RN Synthesis of analogues of acetylmethadol and methadol as potential narcotic antagonists. J Med Chem. 1981 Jul;24(7):903-6. DMRMHE8 RU https://pubmed.ncbi.nlm.nih.gov/6268789 DMRMHE8 DI DMRMHE8 DMRMHE8 DN Dimepheptanol DMRMHE8 MI TTQW87Y DMRMHE8 MN Opioid receptor kappa (OPRK1) DMRMHE8 MT DTT DMRMHE8 MA Inhibitor DMRMHE8 RN Synthesis of analogues of acetylmethadol and methadol as potential narcotic antagonists. J Med Chem. 1981 Jul;24(7):903-6. DMRMHE8 RU https://pubmed.ncbi.nlm.nih.gov/6268789 DMRMHE8 DI DMRMHE8 DMRMHE8 DN Dimepheptanol DMRMHE8 MI TTKWM86 DMRMHE8 MN Opioid receptor mu (MOP) DMRMHE8 MT DTT DMRMHE8 MA Inhibitor DMRMHE8 RN Synthesis of analogues of acetylmethadol and methadol as potential narcotic antagonists. J Med Chem. 1981 Jul;24(7):903-6. DMRMHE8 RU https://pubmed.ncbi.nlm.nih.gov/6268789 DMTVA49 DI DMTVA49 DMTVA49 DN Dimethyl 2,2,2-trifluoro-1-phenylethyl phosphate DMTVA49 MI TTMF541 DMTVA49 MN Liver carboxylesterase (CES1) DMTVA49 MT DTT DMTVA49 MA Inhibitor DMTVA49 RN Synthesis of organophosphates with fluorine-containing leaving groups as serine esterase inhibitors with potential for Alzheimer disease therapeutics. Bioorg Med Chem Lett. 2009 Oct 1;19(19):5528-30. DMTVA49 RU https://pubmed.ncbi.nlm.nih.gov/19717305 DMP5I47 DI DMP5I47 DMP5I47 DN Dimethylallyl Diphosphate DMP5I47 MI TTIKWV4 DMP5I47 MN Geranyltranstransferase (FDPS) DMP5I47 MT DTT DMP5I47 MA Inhibitor DMP5I47 RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DMP5I47 RU https://pubmed.ncbi.nlm.nih.gov/10592235 DM2HYEN DI DM2HYEN DM2HYEN DN dimethylethylamine DM2HYEN MI TTCO25G DM2HYEN MN Trace amine receptor 5 (TAAR5) DM2HYEN MT DTT DM2HYEN MA Agonist DM2HYEN RN Trace amine-associated receptors and their ligands. Br J Pharmacol. 2006 Dec;149(8):967-78. DM2HYEN RU https://pubmed.ncbi.nlm.nih.gov/17088868 DML6O4N DI DML6O4N DML6O4N DN Dimethylformamide DML6O4N MI TTB2MXP DML6O4N MN Angiotensinogenase renin (REN) DML6O4N MT DTT DML6O4N MA Inhibitor DML6O4N RN Liver disease associated with occupational exposure to the solvent dimethylformamide. Ann Intern Med. 1988 May;108(5):680-6. DML6O4N RU https://pubmed.ncbi.nlm.nih.gov/3358569 DML6O4N DI DML6O4N DML6O4N DN Dimethylformamide DML6O4N MI DEVDYN7 DML6O4N MN Cytochrome P450 2E1 (CYP2E1) DML6O4N MT DME DML6O4N MA Metabolism DML6O4N RN Association between CYP2E1 and GOT2 gene polymorphisms and susceptibility and low-dose N,N-dimethylformamide occupational exposure-induced liver injury. Int Arch Occup Environ Health. 2019 Oct;92(7):967-975. DML6O4N RU https://www.ncbi.nlm.nih.gov/pubmed/?term=30993423 DML6O4N DI DML6O4N DML6O4N DN Dimethylformamide DML6O4N MI TT3NKIB DML6O4N MN Pancreatic elastase 1 (CELA1) DML6O4N MT DTT DML6O4N MA Inhibitor DML6O4N RN Liver disease associated with occupational exposure to the solvent dimethylformamide. Ann Intern Med. 1988 May;108(5):680-6. DML6O4N RU https://pubmed.ncbi.nlm.nih.gov/3358569 DMW0MTV DI DMW0MTV DMW0MTV DN DIMETHYLGRISABINE DMW0MTV MI TTVBI8W DMW0MTV MN Dopamine transporter (DAT) DMW0MTV MT DTT DMW0MTV MA Inhibitor DMW0MTV RN Effects of various isoquinoline alkaloids on in vitro 3H-dopamine uptake by rat striatal synaptosomes. J Nat Prod. 1995 Oct;58(10):1475-84. DMW0MTV RU https://pubmed.ncbi.nlm.nih.gov/8676127 DMY0FVU DI DMY0FVU DMY0FVU DN dimethylhistaprodifen DMY0FVU MI TTTIBOJ DMY0FVU MN Histamine H1 receptor (H1R) DMY0FVU MT DTT DMY0FVU MA Agonist DMY0FVU RN Multiple differences in agonist and antagonist pharmacology between human and guinea pig histamine H1-receptor. J Pharmacol Exp Ther. 2003 Jun;305(3):1104-15. DMY0FVU RU https://pubmed.ncbi.nlm.nih.gov/12626648 DMG3WTE DI DMG3WTE DMG3WTE DN Dimethylnordihydroguarierate acid DMG3WTE MI TT12ABZ DMG3WTE MN Arachidonate 12-lipoxygenase (12-LOX) DMG3WTE MT DTT DMG3WTE MA Inhibitor DMG3WTE RN Exploring sponge-derived terpenoids for their potency and selectivity against 12-human, 15-human, and 15-soybean lipoxygenases. J Nat Prod. 2003 Feb;66(2):230-5. DMG3WTE RU https://pubmed.ncbi.nlm.nih.gov/12608855 DMG3WTE DI DMG3WTE DMG3WTE DN Dimethylnordihydroguarierate acid DMG3WTE MI TTN9T81 DMG3WTE MN Arachidonate 15-lipoxygenase (15-LOX) DMG3WTE MT DTT DMG3WTE MA Inhibitor DMG3WTE RN Exploring sponge-derived terpenoids for their potency and selectivity against 12-human, 15-human, and 15-soybean lipoxygenases. J Nat Prod. 2003 Feb;66(2):230-5. DMG3WTE RU https://pubmed.ncbi.nlm.nih.gov/12608855 DMO0UI8 DI DMO0UI8 DMO0UI8 DN Dimethyl-pent-4-enyl-ammonium bromide DMO0UI8 MI TT1RS9F DMO0UI8 MN Acetylcholinesterase (AChE) DMO0UI8 MT DTT DMO0UI8 MA Inhibitor DMO0UI8 RN Structure-based alignment and comparative molecular field analysis of acetylcholinesterase inhibitors. J Med Chem. 1996 Dec 20;39(26):5064-71. DMO0UI8 RU https://pubmed.ncbi.nlm.nih.gov/8978837 DM1OKN0 DI DM1OKN0 DM1OKN0 DN DIMETHYLSPINGOSINE DM1OKN0 MI TTCN0M9 DM1OKN0 MN Sphingosine kinase 2 (SPHK2) DM1OKN0 MT DTT DM1OKN0 MA Inhibitor DM1OKN0 RN Synthesis and evaluation of sphingosine analogues as inhibitors of sphingosine kinases. J Med Chem. 2009 Jun 25;52(12):3618-26. DM1OKN0 RU https://pubmed.ncbi.nlm.nih.gov/19469544 DM7EKAF DI DM7EKAF DM7EKAF DN Dimethylthiambutene DM7EKAF MI TT27RFC DM7EKAF MN Opioid receptor delta (OPRD1) DM7EKAF MT DTT DM7EKAF MA Agonist DM7EKAF RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DM7EKAF RU https://pubmed.ncbi.nlm.nih.gov/17139284 DM7EKAF DI DM7EKAF DM7EKAF DN Dimethylthiambutene DM7EKAF MI TTKWM86 DM7EKAF MN Opioid receptor mu (MOP) DM7EKAF MT DTT DM7EKAF MA Agonist DM7EKAF RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DM7EKAF RU https://pubmed.ncbi.nlm.nih.gov/17139284 DM2Y0AI DI DM2Y0AI DM2Y0AI DN Diminazene DM2Y0AI MI TTM3B5R DM2Y0AI MN Diamine oxidase (AOC1) DM2Y0AI MT DTT DM2Y0AI MA Inhibitor DM2Y0AI RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DM2Y0AI RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMJGKND DI DMJGKND DMJGKND DN DIMS-9054 DMJGKND MI TTSHG0T DMJGKND MN Toll-like receptor 9 (TLR9) DMJGKND MT DTT DMJGKND MA Modulator DMJGKND RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1759). DMJGKND RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1759 DM8CSOJ DI DM8CSOJ DM8CSOJ DN Dinoterb DM8CSOJ MI DEMQRS9 DM8CSOJ MN Cytochrome P450 BM3 (cypBM3) DM8CSOJ MT DME DM8CSOJ MA Metabolism DM8CSOJ RN PEGylation of cytochrome P450 enhances its biocatalytic performance for pesticide transformation. Int J Biol Macromol. 2017 Dec;105(Pt 1):163-170. DM8CSOJ RU https://pubmed.ncbi.nlm.nih.gov/28690168 DMBKJL8 DI DMBKJL8 DMBKJL8 DN DIOA DMBKJL8 MI TTJ8C67 DMBKJL8 MN Solute carrier family 12 member 4 (SLC12A4) DMBKJL8 MT DTT DMBKJL8 MA Inhibitor DMBKJL8 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 971). DMBKJL8 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=971 DMBKJL8 DI DMBKJL8 DMBKJL8 DN DIOA DMBKJL8 MI TTH6UZY DMBKJL8 MN Solute carrier family 12 member 5 (SLC12A5) DMBKJL8 MT DTT DMBKJL8 MA Inhibitor DMBKJL8 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 972). DMBKJL8 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=972 DMBKJL8 DI DMBKJL8 DMBKJL8 DN DIOA DMBKJL8 MI TT8DFHE DMBKJL8 MN Solute carrier family 12 member 6 (SLC12A6) DMBKJL8 MT DTT DMBKJL8 MA Inhibitor DMBKJL8 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 973). DMBKJL8 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=973 DMBKJL8 DI DMBKJL8 DMBKJL8 DN DIOA DMBKJL8 MI TTU2PCD DMBKJL8 MN Solute carrier family 12 member 7 (SLC12A7) DMBKJL8 MT DTT DMBKJL8 MA Inhibitor DMBKJL8 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 974). DMBKJL8 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=974 DM0QY1V DI DM0QY1V DM0QY1V DN dioctanoylglycerol pyrophosphate DM0QY1V MI TTO897C DM0QY1V MN G protein coupled receptor 87 (GPR87) DM0QY1V MT DTT DM0QY1V MA Antagonist DM0QY1V RN The orphan GPCR GPR87 was deorphanized and shown to be a lysophosphatidic acid receptor. Biochem Biophys Res Commun. 2007 Nov 23;363(3):861-6. DM0QY1V RU https://pubmed.ncbi.nlm.nih.gov/17905198 DM0QY1V DI DM0QY1V DM0QY1V DN dioctanoylglycerol pyrophosphate DM0QY1V MI TTE2YJR DM0QY1V MN Lysophosphatidate-3 receptor (LPAR3) DM0QY1V MT DTT DM0QY1V MA Antagonist DM0QY1V RN Short-chain phosphatidates are subtype-selective antagonists of lysophosphatidic acid receptors. Mol Pharmacol. 2001 Oct;60(4):776-84. DM0QY1V RU https://pubmed.ncbi.nlm.nih.gov/11562440 DM0QY1V DI DM0QY1V DM0QY1V DN dioctanoylglycerol pyrophosphate DM0QY1V MI TTQ6S1K DM0QY1V MN Lysophosphatidic acid receptor 1 (LPAR1) DM0QY1V MT DTT DM0QY1V MA Antagonist DM0QY1V RN Short-chain phosphatidates are subtype-selective antagonists of lysophosphatidic acid receptors. Mol Pharmacol. 2001 Oct;60(4):776-84. DM0QY1V RU https://pubmed.ncbi.nlm.nih.gov/11562440 DM0QY1V DI DM0QY1V DM0QY1V DN dioctanoylglycerol pyrophosphate DM0QY1V MI TTMFOU6 DM0QY1V MN P2Y purinoceptor 10 (P2RY10) DM0QY1V MT DTT DM0QY1V MA Antagonist DM0QY1V RN Identification of the orphan GPCR, P2Y(10) receptor as the sphingosine-1-phosphate and lysophosphatidic acid receptor. Biochem Biophys Res Commun. 2008 Jul 11;371(4):707-12. DM0QY1V RU https://pubmed.ncbi.nlm.nih.gov/18466763 DM7D6JV DI DM7D6JV DM7D6JV DN dioleoylphosphatidic acid DM7D6JV MI TT2D5VM DM7D6JV MN G-protein coupled receptor 63 (GPR63) DM7D6JV MT DTT DM7D6JV MA Agonist DM7D6JV RN Sphingosine 1-phosphate and dioleoylphosphatidic acid are low affinity agonists for the orphan receptor GPR63. Cell Signal. 2003 Apr;15(4):435-46. DM7D6JV RU https://pubmed.ncbi.nlm.nih.gov/12618218 DM5G4O7 DI DM5G4O7 DM5G4O7 DN DI-O-METHYLENDIANDRIN A DM5G4O7 MI TTOZRK6 DM5G4O7 MN Glucocorticoid receptor messenger RNA (GCR mRNA) DM5G4O7 MT DTT DM5G4O7 MA Inhibitor DM5G4O7 RN Endiandrin A, a potent glucocorticoid receptor binder isolated from the Australian plant Endiandra anthropophagorum. J Nat Prod. 2007 Jul;70(7):1118-21. DM5G4O7 RU https://pubmed.ncbi.nlm.nih.gov/17583952 DM4KXIM DI DM4KXIM DM4KXIM DN DIOSMETIN DM4KXIM MI TTI84H7 DM4KXIM MN Cytochrome P450 1B1 (CYP1B1) DM4KXIM MT DTT DM4KXIM MA Inhibitor DM4KXIM RN Selective inhibition of methoxyflavonoids on human CYP1B1 activity. Bioorg Med Chem. 2010 Sep 1;18(17):6310-5. DM4KXIM RU https://pubmed.ncbi.nlm.nih.gov/20696580 DML2B04 DI DML2B04 DML2B04 DN DIOXINODEHYDROECKOL DML2B04 MI TT8JRS7 DML2B04 MN Beta-secretase (BACE) DML2B04 MT DTT DML2B04 MA Inhibitor DML2B04 RN Molecular docking studies of phlorotannins from Eisenia bicyclis with BACE1 inhibitory activity. Bioorg Med Chem Lett. 2010 Jun 1;20(11):3211-5. DML2B04 RU https://pubmed.ncbi.nlm.nih.gov/20462757 DM93MAB DI DM93MAB DM93MAB DN Dioxothiomolybdenum(VI) ion DM93MAB MI TT7RJY8 DM93MAB MN Xanthine dehydrogenase/oxidase (XDH) DM93MAB MT DTT DM93MAB MA Inhibitor DM93MAB RN DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Nucleic Acids Res. 2011 Jan;39(Database issue):D1035-41. DM93MAB RU https://pubmed.ncbi.nlm.nih.gov/21059682 DMO4XUC DI DMO4XUC DMO4XUC DN Diphenyl(piperidin-4-yl)methanol DMO4XUC MI TTTIBOJ DMO4XUC MN Histamine H1 receptor (H1R) DMO4XUC MT DTT DMO4XUC MA Inhibitor DMO4XUC RN Structural determinants for histamine H(1) affinity, hERG affinity and QTc prolongation in a series of terfenadine analogs. Bioorg Med Chem Lett. 2009 Sep 1;19(17):5043-7. DMO4XUC RU https://pubmed.ncbi.nlm.nih.gov/19660947 DMP6IHR DI DMP6IHR DMP6IHR DN Diphenylacetic Acid DMP6IHR MI TTF2LRI DMP6IHR MN Cathepsin B (CTSB) DMP6IHR MT DTT DMP6IHR MA Inhibitor DMP6IHR RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMP6IHR RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMBV19T DI DMBV19T DMBV19T DN diphenylamine-2-carboxylic acid DMBV19T MI TT30NW6 DMBV19T MN Chloride channel protein 2 (CLC-2) DMBV19T MT DTT DMBV19T MA Blocker (channel blocker) DMBV19T RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 699). DMBV19T RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=699 DMBV19T DI DMBV19T DMBV19T DN diphenylamine-2-carboxylic acid DMBV19T MI TTST1AJ DMBV19T MN Chloride channel protein 7 (ClC-7) DMBV19T MT DTT DMBV19T MA Blocker (channel blocker) DMBV19T RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 709). DMBV19T RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=709 DMRQZTS DI DMRQZTS DMRQZTS DN diphenylboronic anhydride DMRQZTS MI TTMI6F5 DMRQZTS MN Transient receptor potential cation channel V1 (TRPV1) DMRQZTS MT DTT DMRQZTS MA Activator DMRQZTS RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 507). DMRQZTS RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=507 DMRQZTS DI DMRQZTS DMRQZTS DN diphenylboronic anhydride DMRQZTS MI TTBECWA DMRQZTS MN Transient receptor potential cation channel V2 (TRPV2) DMRQZTS MT DTT DMRQZTS MA Activator DMRQZTS RN Pharmacological characterization and molecular determinants of the activation of transient receptor potential V2 channel orthologs by 2-aminoethoxy... Mol Pharmacol. 2007 Nov;72(5):1258-68. DMRQZTS RU https://pubmed.ncbi.nlm.nih.gov/17673572 DMRQZTS DI DMRQZTS DMRQZTS DN diphenylboronic anhydride DMRQZTS MI TT946IA DMRQZTS MN Transient receptor potential cation channel V3 (TRPV3) DMRQZTS MT DTT DMRQZTS MA Activator DMRQZTS RN Biphasic currents evoked by chemical or thermal activation of the heat-gated ion channel, TRPV3. J Biol Chem. 2005 Apr 22;280(16):15928-41. DMRQZTS RU https://pubmed.ncbi.nlm.nih.gov/15722340 DMB75PV DI DMB75PV DMB75PV DN diphenyleneiodonium chloride DMB75PV MI TTHZVSK DMB75PV MN G protein-coupled receptor 3 (GPR3) DMB75PV MT DTT DMB75PV MA Agonist DMB75PV RN Identification of a novel small-molecule agonist for human G protein-coupled receptor 3. J Pharmacol Exp Ther. 2014 Jun;349(3):437-43. DMB75PV RU https://pubmed.ncbi.nlm.nih.gov/24633425 DMK8T61 DI DMK8T61 DMK8T61 DN diphenyltetrahydrofuran DMK8T61 MI TT946IA DMK8T61 MN Transient receptor potential cation channel V3 (TRPV3) DMK8T61 MT DTT DMK8T61 MA Blocker (channel blocker) DMK8T61 RN Biphasic currents evoked by chemical or thermal activation of the heat-gated ion channel, TRPV3. J Biol Chem. 2005 Apr 22;280(16):15928-41. DMK8T61 RU https://pubmed.ncbi.nlm.nih.gov/15722340 DMHY30B DI DMHY30B DMHY30B DN Diphosphate DMHY30B MI TT8WCXO DMHY30B MN Bacterial NH(3)-dependent NAD(+) synthetase (Bact nadE) DMHY30B MT DTT DMHY30B MA Inhibitor DMHY30B RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMHY30B RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMHY30B DI DMHY30B DMHY30B DN Diphosphate DMHY30B MI TT5B8AX DMHY30B MN Mycobacterium Thymidine monophosphate kinase (MycB tmk) DMHY30B MT DTT DMHY30B MA Inhibitor DMHY30B RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMHY30B RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMHY30B DI DMHY30B DMHY30B DN Diphosphate DMHY30B MI TTYQ4AE DMHY30B MN Plasmodium Adenylosuccinate synthetase (Malaria Adss) DMHY30B MT DTT DMHY30B MA Inhibitor DMHY30B RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMHY30B RU https://pubmed.ncbi.nlm.nih.gov/17139284 DM28NIU DI DM28NIU DM28NIU DN diphosphoglycolyl proline DM28NIU MI TTE5J6X DM28NIU MN Diphosphomevalonate decarboxylase (MVD) DM28NIU MT DTT DM28NIU MA Inhibitor DM28NIU RN Human mevalonate diphosphate decarboxylase: characterization, investigation of the mevalonate diphosphate binding site, and crystal structure. Arch Biochem Biophys. 2008 Dec 1;480(1):58-67. DM28NIU RU https://pubmed.ncbi.nlm.nih.gov/18823933 DMYWL89 DI DMYWL89 DMYWL89 DN diphosphoric acid DMYWL89 MI TTIKWV4 DMYWL89 MN Geranyltranstransferase (FDPS) DMYWL89 MT DTT DMYWL89 MA Inhibitor DMYWL89 RN Structure-activity relationships among the nitrogen containing bisphosphonates in clinical use and other analogues: time-dependent inhibition of hu... J Med Chem. 2008 Apr 10;51(7):2187-95. DMYWL89 RU https://pubmed.ncbi.nlm.nih.gov/18327899 DMRWD9M DI DMRWD9M DMRWD9M DN Diphthamide DMRWD9M MI TTCNGJ5 DMRWD9M MN Candida Elongation factor 2 (Candi EFT2) DMRWD9M MT DTT DMRWD9M MA Inhibitor DMRWD9M RN DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Nucleic Acids Res. 2011 Jan;39(Database issue):D1035-41. DMRWD9M RU https://pubmed.ncbi.nlm.nih.gov/21059682 DMIXPU6 DI DMIXPU6 DMIXPU6 DN Diprenorphine DMIXPU6 MI TT27RFC DMIXPU6 MN Opioid receptor delta (OPRD1) DMIXPU6 MT DTT DMIXPU6 MA Antagonist DMIXPU6 RN [6-O-methyl-11C]Diprenorphine Molecular Imaging and Contrast Agent Database (MICAD) [Internet]. DMIXPU6 RU https://pubmed.ncbi.nlm.nih.gov/20641600 DMIXPU6 DI DMIXPU6 DMIXPU6 DN Diprenorphine DMIXPU6 MI TTQW87Y DMIXPU6 MN Opioid receptor kappa (OPRK1) DMIXPU6 MT DTT DMIXPU6 MA Antagonist DMIXPU6 RN [6-O-methyl-11C]Diprenorphine Molecular Imaging and Contrast Agent Database (MICAD) [Internet]. DMIXPU6 RU https://pubmed.ncbi.nlm.nih.gov/20641600 DMIXPU6 DI DMIXPU6 DMIXPU6 DN Diprenorphine DMIXPU6 MI TTKWM86 DMIXPU6 MN Opioid receptor mu (MOP) DMIXPU6 MT DTT DMIXPU6 MA Antagonist DMIXPU6 RN [6-O-methyl-11C]Diprenorphine Molecular Imaging and Contrast Agent Database (MICAD) [Internet]. DMIXPU6 RU https://pubmed.ncbi.nlm.nih.gov/20641600 DM9VKXC DI DM9VKXC DM9VKXC DN dipropyl-5-CT DM9VKXC MI TTK8CXU DM9VKXC MN 5-HT 1B receptor (HTR1B) DM9VKXC MT DTT DM9VKXC MA Agonist DM9VKXC RN Human serotonin 1D receptor is encoded by a subfamily of two distinct genes: 5-HT1D alpha and 5-HT1D beta. Proc Natl Acad Sci U S A. 1992 Apr 15;89(8):3630-4. DM9VKXC RU https://pubmed.ncbi.nlm.nih.gov/1565658 DM9VKXC DI DM9VKXC DM9VKXC DN dipropyl-5-CT DM9VKXC MI TT6MSOK DM9VKXC MN 5-HT 1D receptor (HTR1D) DM9VKXC MT DTT DM9VKXC MA Agonist DM9VKXC RN Human serotonin 1D receptor is encoded by a subfamily of two distinct genes: 5-HT1D alpha and 5-HT1D beta. Proc Natl Acad Sci U S A. 1992 Apr 15;89(8):3630-4. DM9VKXC RU https://pubmed.ncbi.nlm.nih.gov/1565658 DM9VKXC DI DM9VKXC DM9VKXC DN dipropyl-5-CT DM9VKXC MI TT0MI3F DM9VKXC MN 5-HT 1F receptor (HTR1F) DM9VKXC MT DTT DM9VKXC MA Agonist DM9VKXC RN Cloning of another human serotonin receptor (5-HT1F): a fifth 5-HT1 receptor subtype coupled to the inhibition of adenylate cyclase. Proc Natl Acad Sci U S A. 1993 Jan 15;90(2):408-12. DM9VKXC RU https://pubmed.ncbi.nlm.nih.gov/8380639 DM9VKXC DI DM9VKXC DM9VKXC DN dipropyl-5-CT DM9VKXC MI TTO9X1H DM9VKXC MN 5-HT 7 receptor (HTR7) DM9VKXC MT DTT DM9VKXC MA Agonist DM9VKXC RN Cloning, expression and pharmacology of a truncated splice variant of the human 5-HT7 receptor (h5-HT7b). Br J Pharmacol. 1997 Sep;122(1):126-32. DM9VKXC RU https://pubmed.ncbi.nlm.nih.gov/9298538 DMGBCP0 DI DMGBCP0 DMGBCP0 DN DIPROTIN A DMGBCP0 MI TTDIGC1 DMGBCP0 MN Dipeptidyl peptidase 4 (DPP-4) DMGBCP0 MT DTT DMGBCP0 MA Inhibitor DMGBCP0 RN Inhibition of dipeptidyl peptidase-IV (DPP-IV) by atorvastatin. Bioorg Med Chem Lett. 2008 Jan 15;18(2):479-84. DMGBCP0 RU https://pubmed.ncbi.nlm.nih.gov/18068977 DM2MV9O DI DM2MV9O DM2MV9O DN DIRLOTAPIDE DM2MV9O MI TTUS1RD DM2MV9O MN Microsomal triglyceride transfer protein (MTTP) DM2MV9O MT DTT DM2MV9O MA Inhibitor DM2MV9O RN In vitro and in vivo profile of 5-[(4'-trifluoromethyl-biphenyl-2-carbonyl)-amino]-1H-indole-2-carboxylic acid benzylmethyl carbamoylamide (dirlota... Bioorg Med Chem Lett. 2007 Apr 1;17(7):1996-9. DM2MV9O RU https://pubmed.ncbi.nlm.nih.gov/17276061 DMPVNDK DI DMPVNDK DMPVNDK DN Distamycin A DMPVNDK MI TTOVXHF DMPVNDK MN Human Deoxyribonucleic acid minor groove (hDNA min) DMPVNDK MT DTT DMPVNDK MA Binder (minor groove binder) DMPVNDK RN Development of distamycin-related DNA binding anticancer drugs. Expert Opin Investig Drugs. 2001 Sep;10(9):1703-14. DMPVNDK RU https://pubmed.ncbi.nlm.nih.gov/11772279 DM0GQJ2 DI DM0GQJ2 DM0GQJ2 DN Di-Stearoyl-3-Sn-Phosphatidylcholine DM0GQJ2 MI TTU5A6Q DM0GQJ2 MN Adenine nucleotide translocator 1 (SLC25A4) DM0GQJ2 MT DTT DM0GQJ2 MA Inhibitor DM0GQJ2 RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DM0GQJ2 RU https://pubmed.ncbi.nlm.nih.gov/17139284 DM6TVAX DI DM6TVAX DM6TVAX DN Disulergine DM6TVAX MI TTO9X1H DM6TVAX MN 5-HT 7 receptor (HTR7) DM6TVAX MT DTT DM6TVAX MA Inhibitor DM6TVAX RN Higher-end serotonin receptors: 5-HT(5), 5-HT(6), and 5-HT(7). J Med Chem. 2003 Jul 3;46(14):2795-812. DM6TVAX RU https://pubmed.ncbi.nlm.nih.gov/12825922 DMVJYKG DI DMVJYKG DMVJYKG DN Dithiazoline DMVJYKG MI DE0KTEM DMVJYKG MN L,D-carboxypeptidase A (ldcA) DMVJYKG MT DME DMVJYKG MA Metabolism DMVJYKG RN Selective inhibition of Neisseria gonorrhoeae by a dithiazoline in mixed infections with Lactobacillus gasseri. Antimicrob Agents Chemother. 2018 Nov 26;62(12). pii: e00826-18. DMVJYKG RU https://pubmed.ncbi.nlm.nih.gov/30275084 DMVJYKG DI DMVJYKG DMVJYKG DN Dithiazoline DMVJYKG MI DE19C8A DMVJYKG MN L,D-carboxypeptidase A (ldcA) DMVJYKG MT DME DMVJYKG MA Metabolism DMVJYKG RN Selective inhibition of Neisseria gonorrhoeae by a dithiazoline in mixed infections with Lactobacillus gasseri. Antimicrob Agents Chemother. 2018 Nov 26;62(12). pii: e00826-18. DMVJYKG RU https://pubmed.ncbi.nlm.nih.gov/30275084 DMK0VFS DI DMK0VFS DMK0VFS DN dithiipin-1,1,4,4-tetroxide analogue 7 DMK0VFS MI TTOPAY7 DMK0VFS MN Galanin receptor (GAL-R) DMK0VFS MT DTT DMK0VFS MA Antagonist DMK0VFS RN 2,3-Dihydro-dithiin and -dithiepine-1,1,4,4-tetroxides: small molecule non-peptide antagonists of the human galanin hGAL-1 receptor. Bioorg Med Chem. 2000 Jun;8(6):1383-91. DMK0VFS RU https://pubmed.ncbi.nlm.nih.gov/10896115 DM0QZ6I DI DM0QZ6I DM0QZ6I DN D-kynurenine DM0QZ6I MI TT8WFXV DM0QZ6I MN Hydroxycarboxylic acid receptor 3 (HCAR3) DM0QZ6I MT DTT DM0QZ6I MA Agonist DM0QZ6I RN Aromatic D-amino acids act as chemoattractant factors for human leukocytes through a G protein-coupled receptor, GPR109B. Proc Natl Acad Sci U S A. 2009 Mar 10;106(10):3930-4. DM0QZ6I RU https://pubmed.ncbi.nlm.nih.gov/19237584 DME9ODX DI DME9ODX DME9ODX DN DL-3 DME9ODX MI TTS64P2 DME9ODX MN Androgen receptor (AR) DME9ODX MT DTT DME9ODX MA Antagonist DME9ODX RN The ChEMBL database in 2017. Nucleic Acids Res. 2017 Jan 4;45(D1):D945-D954. DME9ODX RU https://www.ncbi.nlm.nih.gov/pubmed/27899562 DMBNFQ8 DI DMBNFQ8 DMBNFQ8 DN D-lactic acid DMBNFQ8 MI TTVK4ZO DMBNFQ8 MN G protein coupled receptor 81 (HCAR1) DMBNFQ8 MT DTT DMBNFQ8 MA Agonist DMBNFQ8 RN Role of GPR81 in lactate-mediated reduction of adipose lipolysis. Biochem Biophys Res Commun. 2008 Dec 19;377(3):987-91. DMBNFQ8 RU https://pubmed.ncbi.nlm.nih.gov/18952058 DMBNFQ8 DI DMBNFQ8 DMBNFQ8 DN D-lactic acid DMBNFQ8 MI DEINPMH DMBNFQ8 MN Lactate racemase (Lsa784) DMBNFQ8 MT DME DMBNFQ8 MA Metabolism DMBNFQ8 RN The effect of sodium acetate on the growth yield, the production of L- and D-lactic acid, and the activity of some enzymes of the glycolytic pathway of Lactobacillus sakei NRIC 1071(T) and Lactobacillus plantarum NRIC 1067(T). J Gen Appl Microbiol. 2002 Apr;48(2):91-102. DMBNFQ8 RU https://pubmed.ncbi.nlm.nih.gov/12469305 DMHI9ZJ DI DMHI9ZJ DMHI9ZJ DN DL-benzylsuccinic acid DMHI9ZJ MI TT3LJ6G DMHI9ZJ MN Carboxypeptidase A1 (CPA1) DMHI9ZJ MT DTT DMHI9ZJ MA Inhibitor DMHI9ZJ RN A new type of five-membered heterocyclic inhibitors of basic metallocarboxypeptidases. Eur J Med Chem. 2009 Aug;44(8):3266-71. DMHI9ZJ RU https://pubmed.ncbi.nlm.nih.gov/19386397 DMHI9ZJ DI DMHI9ZJ DMHI9ZJ DN DL-benzylsuccinic acid DMHI9ZJ MI TTP18AY DMHI9ZJ MN Carboxypeptidase B2 (CPB2) DMHI9ZJ MT DTT DMHI9ZJ MA Inhibitor DMHI9ZJ RN A new type of five-membered heterocyclic inhibitors of basic metallocarboxypeptidases. Eur J Med Chem. 2009 Aug;44(8):3266-71. DMHI9ZJ RU https://pubmed.ncbi.nlm.nih.gov/19386397 DMVN93B DI DMVN93B DMVN93B DN D-leucyl-N-(3-chlorobenzyl)-L-prolinamide DMVN93B MI TT6L509 DMVN93B MN Coagulation factor IIa (F2) DMVN93B MT DTT DMVN93B MA Inhibitor DMVN93B RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DMVN93B RU https://pubmed.ncbi.nlm.nih.gov/10592235 DMIFCHL DI DMIFCHL DMIFCHL DN D-leucyl-N-(4-carbamimidoylbenzyl)-L-prolinamide DMIFCHL MI TT6L509 DMIFCHL MN Coagulation factor IIa (F2) DMIFCHL MT DTT DMIFCHL MA Inhibitor DMIFCHL RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DMIFCHL RU https://pubmed.ncbi.nlm.nih.gov/10592235 DMM1GXI DI DMM1GXI DMM1GXI DN DL-guanidinoethylmercaptosuccinic acid DMM1GXI MI TTP18AY DMM1GXI MN Carboxypeptidase B2 (CPB2) DMM1GXI MT DTT DMM1GXI MA Inhibitor DMM1GXI RN A new type of five-membered heterocyclic inhibitors of basic metallocarboxypeptidases. Eur J Med Chem. 2009 Aug;44(8):3266-71. DMM1GXI RU https://pubmed.ncbi.nlm.nih.gov/19386397 DM2HGNU DI DM2HGNU DM2HGNU DN DL-TBOA DM2HGNU MI TT8WRDA DM2HGNU MN Excitatory amino acid transporter 1 (SLC1A3) DM2HGNU MT DTT DM2HGNU MA Inhibitor DM2HGNU RN DL-threo-beta-benzyloxyaspartate, a potent blocker of excitatory amino acid transporters. Mol Pharmacol. 1998 Feb;53(2):195-201. DM2HGNU RU https://pubmed.ncbi.nlm.nih.gov/9463476 DM2HGNU DI DM2HGNU DM2HGNU DN DL-TBOA DM2HGNU MI TT2F078 DM2HGNU MN Excitatory amino acid transporter 2 (SLC1A2) DM2HGNU MT DTT DM2HGNU MA Inhibitor DM2HGNU RN DL-threo-beta-benzyloxyaspartate, a potent blocker of excitatory amino acid transporters. Mol Pharmacol. 1998 Feb;53(2):195-201. DM2HGNU RU https://pubmed.ncbi.nlm.nih.gov/9463476 DM2HGNU DI DM2HGNU DM2HGNU DN DL-TBOA DM2HGNU MI TTG2A6F DM2HGNU MN Excitatory amino acid transporter 3 (SLC1A1) DM2HGNU MT DTT DM2HGNU MA Inhibitor DM2HGNU RN Syntheses of optically pure beta-hydroxyaspartate derivatives as glutamate transporter blockers. Bioorg Med Chem Lett. 2000 Nov 6;10(21):2407-10. DM2HGNU RU https://pubmed.ncbi.nlm.nih.gov/11078189 DM2HGNU DI DM2HGNU DM2HGNU DN DL-TBOA DM2HGNU MI TT6KMPN DM2HGNU MN Excitatory amino acid transporter 4 (SLC1A6) DM2HGNU MT DTT DM2HGNU MA Inhibitor DM2HGNU RN Effects of threo-beta-hydroxyaspartate derivatives on excitatory amino acid transporters (EAAT4 and EAAT5). J Neurochem. 2001 Oct;79(2):297-302. DM2HGNU RU https://pubmed.ncbi.nlm.nih.gov/11677257 DM2HGNU DI DM2HGNU DM2HGNU DN DL-TBOA DM2HGNU MI TTK41DM DM2HGNU MN Excitatory amino acid transporter 5 (SLC1A7) DM2HGNU MT DTT DM2HGNU MA Inhibitor DM2HGNU RN Effects of threo-beta-hydroxyaspartate derivatives on excitatory amino acid transporters (EAAT4 and EAAT5). J Neurochem. 2001 Oct;79(2):297-302. DM2HGNU RU https://pubmed.ncbi.nlm.nih.gov/11677257 DMPD2XF DI DMPD2XF DMPD2XF DN DLX-521 DMPD2XF MI TTPMQSO DMPD2XF MN ALK tyrosine kinase receptor (ALK) DMPD2XF MT DTT DMPD2XF RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1839). DMPD2XF RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1839 DMRYQVJ DI DMRYQVJ DMRYQVJ DN DM-107 DMRYQVJ MI TTJLNAW DMRYQVJ MN Tissue kallikrein (KLK2) DMRYQVJ MT DTT DMRYQVJ MA Inhibitor DMRYQVJ RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2372). DMRYQVJ RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2372 DMM0VDK DI DMM0VDK DMM0VDK DN DM-1451 DMM0VDK MI TTJS8PY DMM0VDK MN 5-HT 6 receptor (HTR6) DMM0VDK MT DTT DMM0VDK MA Agonist DMM0VDK RN Interactions of the novel antipsychotic aripiprazole (OPC-14597) with dopamine and serotonin receptor subtypes. Neuropsychopharmacology. 1999 Jun;20(6):612-27. DMM0VDK RU https://pubmed.ncbi.nlm.nih.gov/10327430 DMM0VDK DI DMM0VDK DMM0VDK DN DM-1451 DMM0VDK MI TTO9X1H DMM0VDK MN 5-HT 7 receptor (HTR7) DMM0VDK MT DTT DMM0VDK MA Agonist DMM0VDK RN Interactions of the novel antipsychotic aripiprazole (OPC-14597) with dopamine and serotonin receptor subtypes. Neuropsychopharmacology. 1999 Jun;20(6):612-27. DMM0VDK RU https://pubmed.ncbi.nlm.nih.gov/10327430 DMSXI6W DI DMSXI6W DMSXI6W DN DM-204 DMSXI6W MI TTRSMW9 DMSXI6W MN Glycogen synthase kinase-3 beta (GSK-3B) DMSXI6W MT DTT DMSXI6W RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2030). DMSXI6W RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2030 DM7YXKL DI DM7YXKL DM7YXKL DN DM3A6S DM7YXKL MI TTKWM86 DM7YXKL MN Opioid receptor mu (MOP) DM7YXKL MT DTT DM7YXKL MA Inhibitor DM7YXKL RN Opiate receptor binding properties of morphine-, dihydromorphine-, and codeine 6-O-sulfate ester congeners. Bioorg Med Chem Lett. 2006 Aug 15;16(16):4291-5. DM7YXKL RU https://pubmed.ncbi.nlm.nih.gov/16777416 DML68UF DI DML68UF DML68UF DN DM3B6S DML68UF MI TTKWM86 DML68UF MN Opioid receptor mu (MOP) DML68UF MT DTT DML68UF MA Inhibitor DML68UF RN Opiate receptor binding properties of morphine-, dihydromorphine-, and codeine 6-O-sulfate ester congeners. Bioorg Med Chem Lett. 2006 Aug 15;16(16):4291-5. DML68UF RU https://pubmed.ncbi.nlm.nih.gov/16777416 DMAJ0Q8 DI DMAJ0Q8 DMAJ0Q8 DN DM6S DMAJ0Q8 MI TTQW87Y DMAJ0Q8 MN Opioid receptor kappa (OPRK1) DMAJ0Q8 MT DTT DMAJ0Q8 MA Inhibitor DMAJ0Q8 RN Opiate receptor binding properties of morphine-, dihydromorphine-, and codeine 6-O-sulfate ester congeners. Bioorg Med Chem Lett. 2006 Aug 15;16(16):4291-5. DMAJ0Q8 RU https://pubmed.ncbi.nlm.nih.gov/16777416 DMAJ0Q8 DI DMAJ0Q8 DMAJ0Q8 DN DM6S DMAJ0Q8 MI TTKWM86 DMAJ0Q8 MN Opioid receptor mu (MOP) DMAJ0Q8 MT DTT DMAJ0Q8 MA Inhibitor DMAJ0Q8 RN Opiate receptor binding properties of morphine-, dihydromorphine-, and codeine 6-O-sulfate ester congeners. Bioorg Med Chem Lett. 2006 Aug 15;16(16):4291-5. DMAJ0Q8 RU https://pubmed.ncbi.nlm.nih.gov/16777416 DMT6X03 DI DMT6X03 DMT6X03 DN D-mannose DMT6X03 MI DE26IS8 DMT6X03 MN Beta-galactosidase (bgaB) DMT6X03 MT DME DMT6X03 MA Metabolism DMT6X03 RN Genetic diversity of Leptotrichia and description of Leptotrichia goodfellowii sp. nov., Leptotrichia hofstadii sp. nov., Leptotrichia shahii sp. nov. and Leptotrichia wadei sp. nov. Int J Syst Evol Microbiol. 2004 Mar;54(Pt 2):583-592. DMT6X03 RU https://pubmed.ncbi.nlm.nih.gov/15023979 DMT6X03 DI DMT6X03 DMT6X03 DN D-mannose DMT6X03 MI DEXTCU0 DMT6X03 MN Beta-galactosidase (bgaB) DMT6X03 MT DME DMT6X03 MA Metabolism DMT6X03 RN Genetic diversity of Leptotrichia and description of Leptotrichia goodfellowii sp. nov., Leptotrichia hofstadii sp. nov., Leptotrichia shahii sp. nov. and Leptotrichia wadei sp. nov. Int J Syst Evol Microbiol. 2004 Mar;54(Pt 2):583-592. DMT6X03 RU https://pubmed.ncbi.nlm.nih.gov/15023979 DMT6X03 DI DMT6X03 DMT6X03 DN D-mannose DMT6X03 MI DEVSIE6 DMT6X03 MN Glyceraldehyde-3-phosphate dehydrogenase (gap) DMT6X03 MT DME DMT6X03 MA Metabolism DMT6X03 RN Cloning, expression and characterization of a mucin-binding GAPDH from Lactobacillus acidophilus. Int J Biol Macromol. 2016 Oct;91:338-46. DMT6X03 RU https://pubmed.ncbi.nlm.nih.gov/27180300 DMT6X03 DI DMT6X03 DMT6X03 DN D-mannose DMT6X03 MI DT1CP40 DMT6X03 MN Sodium/glucose cotransporter 4 (SLC5A9) DMT6X03 MT DTP DMT6X03 MA Substrate DMT6X03 RN SLC5A9/SGLT4, a new Na+-dependent glucose transporter, is an essential transporter for mannose, 1,5-anhydro-D-glucitol, and fructose. Life Sci. 2005 Jan 14;76(9):1039-50. DMT6X03 RU http://www.ncbi.nlm.nih.gov/pubmed/15607332 DM7O1IW DI DM7O1IW DM7O1IW DN D-mannose 1-phosphate DM7O1IW MI DEJFMQ8 DM7O1IW MN Phosphomannomutase 1 (PMM1) DM7O1IW MT DME DM7O1IW MA Metabolism DM7O1IW RN The X-ray crystal structures of human alpha-phosphomannomutase 1 reveal the structural basis of congenital disorder of glycosylation type 1a. J Biol Chem. 2006 May 26;281(21):14918-26. DM7O1IW RU https://www.ncbi.nlm.nih.gov/pubmed/?term=16540464 DM7O1IW DI DM7O1IW DM7O1IW DN D-mannose 1-phosphate DM7O1IW MI DEBRX3L DM7O1IW MN Phosphomannomutase 2 (PMM2) DM7O1IW MT DME DM7O1IW MA Metabolism DM7O1IW RN The X-ray crystal structures of human alpha-phosphomannomutase 1 reveal the structural basis of congenital disorder of glycosylation type 1a. J Biol Chem. 2006 May 26;281(21):14918-26. DM7O1IW RU https://www.ncbi.nlm.nih.gov/pubmed/?term=16540464 DM7O1IW DI DM7O1IW DM7O1IW DN D-mannose 1-phosphate DM7O1IW MI TTLP3GX DM7O1IW MN Pseudomonas Phosphomannomutase/phosphoglucomutase (Pseudo algC) DM7O1IW MT DTT DM7O1IW MA Inhibitor DM7O1IW RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DM7O1IW RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMK3WY4 DI DMK3WY4 DMK3WY4 DN DMCM DMK3WY4 MI TTBMV1G DMK3WY4 MN GABA(A) receptor alpha-2 (GABRA2) DMK3WY4 MT DTT DMK3WY4 MA Modulator (allosteric modulator) DMK3WY4 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 405). DMK3WY4 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=405 DMK3WY4 DI DMK3WY4 DMK3WY4 DN DMCM DMK3WY4 MI TT37EDJ DMK3WY4 MN GABA(A) receptor alpha-3 (GABRA3) DMK3WY4 MT DTT DMK3WY4 MA Modulator (allosteric modulator) DMK3WY4 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 406). DMK3WY4 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=406 DMK3WY4 DI DMK3WY4 DMK3WY4 DN DMCM DMK3WY4 MI TTNZPQ1 DMK3WY4 MN GABA(A) receptor alpha-5 (GABRA5) DMK3WY4 MT DTT DMK3WY4 MA Modulator (allosteric modulator) DMK3WY4 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 408). DMK3WY4 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=408 DMK3WY4 DI DMK3WY4 DMK3WY4 DN DMCM DMK3WY4 MI TTEX6LM DMK3WY4 MN GABA(A) receptor gamma-3 (GABRG3) DMK3WY4 MT DTT DMK3WY4 MA Modulator (allosteric modulator) DMK3WY4 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 415). DMK3WY4 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=415 DMOJ92D DI DMOJ92D DMOJ92D DN DMI-bisphosphate DMOJ92D MI DEBJ2NL DMOJ92D MN Inositol polyphosphate 4-phosphatase I (INPP4A) DMOJ92D MT DME DMOJ92D MA Metabolism DMOJ92D RN The cDNA cloning and characterization of inositol polyphosphate 4-phosphatase type II. Evidence for conserved alternative splicing in the 4-phosphatase family. J Biol Chem. 1997 Sep 19;272(38):23859-64. DMOJ92D RU https://www.ncbi.nlm.nih.gov/pubmed/?term=9295334 DM3GYFZ DI DM3GYFZ DM3GYFZ DN DMI-trisphosphate DM3GYFZ MI DEBJ2NL DM3GYFZ MN Inositol polyphosphate 4-phosphatase I (INPP4A) DM3GYFZ MT DME DM3GYFZ MA Metabolism DM3GYFZ RN The cDNA cloning and characterization of inositol polyphosphate 4-phosphatase type II. Evidence for conserved alternative splicing in the 4-phosphatase family. J Biol Chem. 1997 Sep 19;272(38):23859-64. DM3GYFZ RU https://www.ncbi.nlm.nih.gov/pubmed/?term=9295334 DMNRLA7 DI DMNRLA7 DMNRLA7 DN DMP-695/696 DMNRLA7 MI TT7EFHR DMNRLA7 MN Corticotropin-releasing factor receptor 1 (CRHR1) DMNRLA7 MT DTT DMNRLA7 MA Antagonist DMNRLA7 RN A review of drug options in age-related macular degeneration therapy and potential new agents. Expert Opin Pharmacother. 2006 Dec;7(17):2355-68. DMNRLA7 RU https://pubmed.ncbi.nlm.nih.gov/17109611 DMUGPD1 DI DMUGPD1 DMUGPD1 DN DM-PPP DMUGPD1 MI TTVBPDM DMUGPD1 MN Metabotropic glutamate receptor 1 (mGluR1) DMUGPD1 MT DTT DMUGPD1 MA Modulator (allosteric modulator) DMUGPD1 RN Synthesis and pharmacological characterisation of 2,4-dicarboxy-pyrroles as selective non-competitive mGluR1 antagonists. Bioorg Med Chem. 2003 Jan 17;11(2):171-83. DMUGPD1 RU https://pubmed.ncbi.nlm.nih.gov/12470711 DM5WEFK DI DM5WEFK DM5WEFK DN Dmt-Pro-3,5Dmp-Phe-NH2 DM5WEFK MI TT27RFC DM5WEFK MN Opioid receptor delta (OPRD1) DM5WEFK MT DTT DM5WEFK MA Inhibitor DM5WEFK RN Bifunctional [2',6'-dimethyl-L-tyrosine1]endomorphin-2 analogues substituted at position 3 with alkylated phenylalanine derivatives yield potent mi... J Med Chem. 2007 Jun 14;50(12):2753-66. DM5WEFK RU https://pubmed.ncbi.nlm.nih.gov/17497839 DM5WEFK DI DM5WEFK DM5WEFK DN Dmt-Pro-3,5Dmp-Phe-NH2 DM5WEFK MI TTQW87Y DM5WEFK MN Opioid receptor kappa (OPRK1) DM5WEFK MT DTT DM5WEFK MA Inhibitor DM5WEFK RN Bifunctional [2',6'-dimethyl-L-tyrosine1]endomorphin-2 analogues substituted at position 3 with alkylated phenylalanine derivatives yield potent mi... J Med Chem. 2007 Jun 14;50(12):2753-66. DM5WEFK RU https://pubmed.ncbi.nlm.nih.gov/17497839 DM5WEFK DI DM5WEFK DM5WEFK DN Dmt-Pro-3,5Dmp-Phe-NH2 DM5WEFK MI TTKWM86 DM5WEFK MN Opioid receptor mu (MOP) DM5WEFK MT DTT DM5WEFK MA Inhibitor DM5WEFK RN Bifunctional [2',6'-dimethyl-L-tyrosine1]endomorphin-2 analogues substituted at position 3 with alkylated phenylalanine derivatives yield potent mi... J Med Chem. 2007 Jun 14;50(12):2753-66. DM5WEFK RU https://pubmed.ncbi.nlm.nih.gov/17497839 DMGUIR1 DI DMGUIR1 DMGUIR1 DN Dmt-Pro-Dmp-Phe-NH2 DMGUIR1 MI TT27RFC DMGUIR1 MN Opioid receptor delta (OPRD1) DMGUIR1 MT DTT DMGUIR1 MA Inhibitor DMGUIR1 RN Bifunctional [2',6'-dimethyl-L-tyrosine1]endomorphin-2 analogues substituted at position 3 with alkylated phenylalanine derivatives yield potent mi... J Med Chem. 2007 Jun 14;50(12):2753-66. DMGUIR1 RU https://pubmed.ncbi.nlm.nih.gov/17497839 DMGUIR1 DI DMGUIR1 DMGUIR1 DN Dmt-Pro-Dmp-Phe-NH2 DMGUIR1 MI TTQW87Y DMGUIR1 MN Opioid receptor kappa (OPRK1) DMGUIR1 MT DTT DMGUIR1 MA Inhibitor DMGUIR1 RN Bifunctional [2',6'-dimethyl-L-tyrosine1]endomorphin-2 analogues substituted at position 3 with alkylated phenylalanine derivatives yield potent mi... J Med Chem. 2007 Jun 14;50(12):2753-66. DMGUIR1 RU https://pubmed.ncbi.nlm.nih.gov/17497839 DMGUIR1 DI DMGUIR1 DMGUIR1 DN Dmt-Pro-Dmp-Phe-NH2 DMGUIR1 MI TTKWM86 DMGUIR1 MN Opioid receptor mu (MOP) DMGUIR1 MT DTT DMGUIR1 MA Inhibitor DMGUIR1 RN Bifunctional [2',6'-dimethyl-L-tyrosine1]endomorphin-2 analogues substituted at position 3 with alkylated phenylalanine derivatives yield potent mi... J Med Chem. 2007 Jun 14;50(12):2753-66. DMGUIR1 RU https://pubmed.ncbi.nlm.nih.gov/17497839 DM4VEU2 DI DM4VEU2 DM4VEU2 DN Dmt-Pro-Dmt-Phe-NH2 DM4VEU2 MI TT27RFC DM4VEU2 MN Opioid receptor delta (OPRD1) DM4VEU2 MT DTT DM4VEU2 MA Inhibitor DM4VEU2 RN Bifunctional [2',6'-dimethyl-L-tyrosine1]endomorphin-2 analogues substituted at position 3 with alkylated phenylalanine derivatives yield potent mi... J Med Chem. 2007 Jun 14;50(12):2753-66. DM4VEU2 RU https://pubmed.ncbi.nlm.nih.gov/17497839 DM4VEU2 DI DM4VEU2 DM4VEU2 DN Dmt-Pro-Dmt-Phe-NH2 DM4VEU2 MI TTQW87Y DM4VEU2 MN Opioid receptor kappa (OPRK1) DM4VEU2 MT DTT DM4VEU2 MA Inhibitor DM4VEU2 RN Bifunctional [2',6'-dimethyl-L-tyrosine1]endomorphin-2 analogues substituted at position 3 with alkylated phenylalanine derivatives yield potent mi... J Med Chem. 2007 Jun 14;50(12):2753-66. DM4VEU2 RU https://pubmed.ncbi.nlm.nih.gov/17497839 DM4VEU2 DI DM4VEU2 DM4VEU2 DN Dmt-Pro-Dmt-Phe-NH2 DM4VEU2 MI TTKWM86 DM4VEU2 MN Opioid receptor mu (MOP) DM4VEU2 MT DTT DM4VEU2 MA Inhibitor DM4VEU2 RN Bifunctional [2',6'-dimethyl-L-tyrosine1]endomorphin-2 analogues substituted at position 3 with alkylated phenylalanine derivatives yield potent mi... J Med Chem. 2007 Jun 14;50(12):2753-66. DM4VEU2 RU https://pubmed.ncbi.nlm.nih.gov/17497839 DM06VGY DI DM06VGY DM06VGY DN Dmt-Pro-Emp-Phe-NH2 DM06VGY MI TT27RFC DM06VGY MN Opioid receptor delta (OPRD1) DM06VGY MT DTT DM06VGY MA Inhibitor DM06VGY RN Bifunctional [2',6'-dimethyl-L-tyrosine1]endomorphin-2 analogues substituted at position 3 with alkylated phenylalanine derivatives yield potent mi... J Med Chem. 2007 Jun 14;50(12):2753-66. DM06VGY RU https://pubmed.ncbi.nlm.nih.gov/17497839 DM06VGY DI DM06VGY DM06VGY DN Dmt-Pro-Emp-Phe-NH2 DM06VGY MI TTQW87Y DM06VGY MN Opioid receptor kappa (OPRK1) DM06VGY MT DTT DM06VGY MA Inhibitor DM06VGY RN Bifunctional [2',6'-dimethyl-L-tyrosine1]endomorphin-2 analogues substituted at position 3 with alkylated phenylalanine derivatives yield potent mi... J Med Chem. 2007 Jun 14;50(12):2753-66. DM06VGY RU https://pubmed.ncbi.nlm.nih.gov/17497839 DM06VGY DI DM06VGY DM06VGY DN Dmt-Pro-Emp-Phe-NH2 DM06VGY MI TTKWM86 DM06VGY MN Opioid receptor mu (MOP) DM06VGY MT DTT DM06VGY MA Inhibitor DM06VGY RN Bifunctional [2',6'-dimethyl-L-tyrosine1]endomorphin-2 analogues substituted at position 3 with alkylated phenylalanine derivatives yield potent mi... J Med Chem. 2007 Jun 14;50(12):2753-66. DM06VGY RU https://pubmed.ncbi.nlm.nih.gov/17497839 DMXUI1J DI DMXUI1J DMXUI1J DN Dmt-Pro-Imp-Phe-NH2 DMXUI1J MI TT27RFC DMXUI1J MN Opioid receptor delta (OPRD1) DMXUI1J MT DTT DMXUI1J MA Inhibitor DMXUI1J RN Bifunctional [2',6'-dimethyl-L-tyrosine1]endomorphin-2 analogues substituted at position 3 with alkylated phenylalanine derivatives yield potent mi... J Med Chem. 2007 Jun 14;50(12):2753-66. DMXUI1J RU https://pubmed.ncbi.nlm.nih.gov/17497839 DMXUI1J DI DMXUI1J DMXUI1J DN Dmt-Pro-Imp-Phe-NH2 DMXUI1J MI TTQW87Y DMXUI1J MN Opioid receptor kappa (OPRK1) DMXUI1J MT DTT DMXUI1J MA Inhibitor DMXUI1J RN Bifunctional [2',6'-dimethyl-L-tyrosine1]endomorphin-2 analogues substituted at position 3 with alkylated phenylalanine derivatives yield potent mi... J Med Chem. 2007 Jun 14;50(12):2753-66. DMXUI1J RU https://pubmed.ncbi.nlm.nih.gov/17497839 DMXUI1J DI DMXUI1J DMXUI1J DN Dmt-Pro-Imp-Phe-NH2 DMXUI1J MI TTKWM86 DMXUI1J MN Opioid receptor mu (MOP) DMXUI1J MT DTT DMXUI1J MA Inhibitor DMXUI1J RN Bifunctional [2',6'-dimethyl-L-tyrosine1]endomorphin-2 analogues substituted at position 3 with alkylated phenylalanine derivatives yield potent mi... J Med Chem. 2007 Jun 14;50(12):2753-66. DMXUI1J RU https://pubmed.ncbi.nlm.nih.gov/17497839 DM78PFN DI DM78PFN DM78PFN DN Dmt-Pro-Mmp-Phe-NH2 DM78PFN MI TT27RFC DM78PFN MN Opioid receptor delta (OPRD1) DM78PFN MT DTT DM78PFN MA Inhibitor DM78PFN RN Bifunctional [2',6'-dimethyl-L-tyrosine1]endomorphin-2 analogues substituted at position 3 with alkylated phenylalanine derivatives yield potent mi... J Med Chem. 2007 Jun 14;50(12):2753-66. DM78PFN RU https://pubmed.ncbi.nlm.nih.gov/17497839 DM78PFN DI DM78PFN DM78PFN DN Dmt-Pro-Mmp-Phe-NH2 DM78PFN MI TTQW87Y DM78PFN MN Opioid receptor kappa (OPRK1) DM78PFN MT DTT DM78PFN MA Inhibitor DM78PFN RN Bifunctional [2',6'-dimethyl-L-tyrosine1]endomorphin-2 analogues substituted at position 3 with alkylated phenylalanine derivatives yield potent mi... J Med Chem. 2007 Jun 14;50(12):2753-66. DM78PFN RU https://pubmed.ncbi.nlm.nih.gov/17497839 DM78PFN DI DM78PFN DM78PFN DN Dmt-Pro-Mmp-Phe-NH2 DM78PFN MI TTKWM86 DM78PFN MN Opioid receptor mu (MOP) DM78PFN MT DTT DM78PFN MA Inhibitor DM78PFN RN Bifunctional [2',6'-dimethyl-L-tyrosine1]endomorphin-2 analogues substituted at position 3 with alkylated phenylalanine derivatives yield potent mi... J Med Chem. 2007 Jun 14;50(12):2753-66. DM78PFN RU https://pubmed.ncbi.nlm.nih.gov/17497839 DM0VCWA DI DM0VCWA DM0VCWA DN Dmt-Pro-Phe-D-1-Nal-NH2 DM0VCWA MI TT27RFC DM0VCWA MN Opioid receptor delta (OPRD1) DM0VCWA MT DTT DM0VCWA MA Inhibitor DM0VCWA RN Synthesis and characterization of potent and selective mu-opioid receptor antagonists, [Dmt(1), D-2-Nal(4)]endomorphin-1 (Antanal-1) and [Dmt(1), D... J Med Chem. 2007 Feb 8;50(3):512-20. DM0VCWA RU https://pubmed.ncbi.nlm.nih.gov/17266203 DM0VCWA DI DM0VCWA DM0VCWA DN Dmt-Pro-Phe-D-1-Nal-NH2 DM0VCWA MI TTKWM86 DM0VCWA MN Opioid receptor mu (MOP) DM0VCWA MT DTT DM0VCWA MA Inhibitor DM0VCWA RN Synthesis and characterization of potent and selective mu-opioid receptor antagonists, [Dmt(1), D-2-Nal(4)]endomorphin-1 (Antanal-1) and [Dmt(1), D... J Med Chem. 2007 Feb 8;50(3):512-20. DM0VCWA RU https://pubmed.ncbi.nlm.nih.gov/17266203 DMRJVE8 DI DMRJVE8 DMRJVE8 DN Dmt-Pro-Phe-D-2-Nal-NH2 DMRJVE8 MI TT27RFC DMRJVE8 MN Opioid receptor delta (OPRD1) DMRJVE8 MT DTT DMRJVE8 MA Inhibitor DMRJVE8 RN Synthesis and characterization of potent and selective mu-opioid receptor antagonists, [Dmt(1), D-2-Nal(4)]endomorphin-1 (Antanal-1) and [Dmt(1), D... J Med Chem. 2007 Feb 8;50(3):512-20. DMRJVE8 RU https://pubmed.ncbi.nlm.nih.gov/17266203 DMRJVE8 DI DMRJVE8 DMRJVE8 DN Dmt-Pro-Phe-D-2-Nal-NH2 DMRJVE8 MI TTKWM86 DMRJVE8 MN Opioid receptor mu (MOP) DMRJVE8 MT DTT DMRJVE8 MA Inhibitor DMRJVE8 RN Synthesis and characterization of potent and selective mu-opioid receptor antagonists, [Dmt(1), D-2-Nal(4)]endomorphin-1 (Antanal-1) and [Dmt(1), D... J Med Chem. 2007 Feb 8;50(3):512-20. DMRJVE8 RU https://pubmed.ncbi.nlm.nih.gov/17266203 DMM8BIE DI DMM8BIE DMM8BIE DN Dmt-Pro-Phe-Phe-NH2 DMM8BIE MI TT27RFC DMM8BIE MN Opioid receptor delta (OPRD1) DMM8BIE MT DTT DMM8BIE MA Inhibitor DMM8BIE RN Bifunctional [2',6'-dimethyl-L-tyrosine1]endomorphin-2 analogues substituted at position 3 with alkylated phenylalanine derivatives yield potent mi... J Med Chem. 2007 Jun 14;50(12):2753-66. DMM8BIE RU https://pubmed.ncbi.nlm.nih.gov/17497839 DMM8BIE DI DMM8BIE DMM8BIE DN Dmt-Pro-Phe-Phe-NH2 DMM8BIE MI TTQW87Y DMM8BIE MN Opioid receptor kappa (OPRK1) DMM8BIE MT DTT DMM8BIE MA Inhibitor DMM8BIE RN Bifunctional [2',6'-dimethyl-L-tyrosine1]endomorphin-2 analogues substituted at position 3 with alkylated phenylalanine derivatives yield potent mi... J Med Chem. 2007 Jun 14;50(12):2753-66. DMM8BIE RU https://pubmed.ncbi.nlm.nih.gov/17497839 DMM8BIE DI DMM8BIE DMM8BIE DN Dmt-Pro-Phe-Phe-NH2 DMM8BIE MI TTKWM86 DMM8BIE MN Opioid receptor mu (MOP) DMM8BIE MT DTT DMM8BIE MA Inhibitor DMM8BIE RN Bifunctional [2',6'-dimethyl-L-tyrosine1]endomorphin-2 analogues substituted at position 3 with alkylated phenylalanine derivatives yield potent mi... J Med Chem. 2007 Jun 14;50(12):2753-66. DMM8BIE RU https://pubmed.ncbi.nlm.nih.gov/17497839 DMEMQAK DI DMEMQAK DMEMQAK DN Dmt-Pro-Tmp-Phe-NH2 DMEMQAK MI TT27RFC DMEMQAK MN Opioid receptor delta (OPRD1) DMEMQAK MT DTT DMEMQAK MA Inhibitor DMEMQAK RN Bifunctional [2',6'-dimethyl-L-tyrosine1]endomorphin-2 analogues substituted at position 3 with alkylated phenylalanine derivatives yield potent mi... J Med Chem. 2007 Jun 14;50(12):2753-66. DMEMQAK RU https://pubmed.ncbi.nlm.nih.gov/17497839 DMEMQAK DI DMEMQAK DMEMQAK DN Dmt-Pro-Tmp-Phe-NH2 DMEMQAK MI TTQW87Y DMEMQAK MN Opioid receptor kappa (OPRK1) DMEMQAK MT DTT DMEMQAK MA Inhibitor DMEMQAK RN Bifunctional [2',6'-dimethyl-L-tyrosine1]endomorphin-2 analogues substituted at position 3 with alkylated phenylalanine derivatives yield potent mi... J Med Chem. 2007 Jun 14;50(12):2753-66. DMEMQAK RU https://pubmed.ncbi.nlm.nih.gov/17497839 DMEMQAK DI DMEMQAK DMEMQAK DN Dmt-Pro-Tmp-Phe-NH2 DMEMQAK MI TTKWM86 DMEMQAK MN Opioid receptor mu (MOP) DMEMQAK MT DTT DMEMQAK MA Inhibitor DMEMQAK RN Bifunctional [2',6'-dimethyl-L-tyrosine1]endomorphin-2 analogues substituted at position 3 with alkylated phenylalanine derivatives yield potent mi... J Med Chem. 2007 Jun 14;50(12):2753-66. DMEMQAK RU https://pubmed.ncbi.nlm.nih.gov/17497839 DMKEV5U DI DMKEV5U DMKEV5U DN Dmt-Pro-Trp-D-2-Nal-NH2 DMKEV5U MI TT27RFC DMKEV5U MN Opioid receptor delta (OPRD1) DMKEV5U MT DTT DMKEV5U MA Inhibitor DMKEV5U RN Synthesis and characterization of potent and selective mu-opioid receptor antagonists, [Dmt(1), D-2-Nal(4)]endomorphin-1 (Antanal-1) and [Dmt(1), D... J Med Chem. 2007 Feb 8;50(3):512-20. DMKEV5U RU https://pubmed.ncbi.nlm.nih.gov/17266203 DMKEV5U DI DMKEV5U DMKEV5U DN Dmt-Pro-Trp-D-2-Nal-NH2 DMKEV5U MI TTKWM86 DMKEV5U MN Opioid receptor mu (MOP) DMKEV5U MT DTT DMKEV5U MA Inhibitor DMKEV5U RN Synthesis and characterization of potent and selective mu-opioid receptor antagonists, [Dmt(1), D-2-Nal(4)]endomorphin-1 (Antanal-1) and [Dmt(1), D... J Med Chem. 2007 Feb 8;50(3):512-20. DMKEV5U RU https://pubmed.ncbi.nlm.nih.gov/17266203 DMHRT0F DI DMHRT0F DMHRT0F DN Dmt-Sar-Phe-D-2-Nal-NH DMHRT0F MI TTKWM86 DMHRT0F MN Opioid receptor mu (MOP) DMHRT0F MT DTT DMHRT0F MA Inhibitor DMHRT0F RN Novel highly potent mu-opioid receptor antagonist based on endomorphin-2 structure. Bioorg Med Chem Lett. 2008 Feb 15;18(4):1350-3. DMHRT0F RU https://pubmed.ncbi.nlm.nih.gov/18207400 DMNUKIX DI DMNUKIX DMNUKIX DN D-myo-inositol 1,4,5-trisphosphate DMNUKIX MI TTC9IZL DMNUKIX MN Inositol 1,4,5-trisphosphate receptor (ITPR) DMNUKIX MT DTT DMNUKIX MA Inhibitor DMNUKIX RN DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Nucleic Acids Res. 2011 Jan;39(Database issue):D1035-41. DMNUKIX RU https://pubmed.ncbi.nlm.nih.gov/21059682 DMNUKIX DI DMNUKIX DMNUKIX DN D-myo-inositol 1,4,5-trisphosphate DMNUKIX MI DESA9EX DMNUKIX MN Inositol polyphosphate multikinase (IPMK) DMNUKIX MT DME DMNUKIX MA Metabolism DMNUKIX RN The human homologue of yeast ArgRIII protein is an inositol phosphate multikinase with predominantly nuclear localization. Biochem J. 2002 Sep 1;366(Pt 2):549-56. DMNUKIX RU https://www.ncbi.nlm.nih.gov/pubmed/?term=12027805 DMQXPA5 DI DMQXPA5 DMQXPA5 DN DNQX DMQXPA5 MI TTAN6JD DMQXPA5 MN Glutamate receptor AMPA (GRIA) DMQXPA5 MT DTT DMQXPA5 MA Inhibitor DMQXPA5 RN Synthesis of chiral 1-(2'-amino-2'-carboxyethyl)-1,4-dihydro-6,7-quinoxaline-2,3-diones: alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate recep... J Med Chem. 1996 Oct 25;39(22):4430-8. DMQXPA5 RU https://pubmed.ncbi.nlm.nih.gov/8893837 DMQXPA5 DI DMQXPA5 DMQXPA5 DN DNQX DMQXPA5 MI TTVPQTF DMQXPA5 MN Glutamate receptor AMPA 1 (GRIA1) DMQXPA5 MT DTT DMQXPA5 MA Inhibitor DMQXPA5 RN Synthesis of chiral 1-(2'-amino-2'-carboxyethyl)-1,4-dihydro-6,7-quinoxaline-2,3-diones: alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate recep... J Med Chem. 1996 Oct 25;39(22):4430-8. DMQXPA5 RU https://pubmed.ncbi.nlm.nih.gov/8893837 DMQXPA5 DI DMQXPA5 DMQXPA5 DN DNQX DMQXPA5 MI TT0MYE2 DMQXPA5 MN Glutamate receptor ionotropic kainate 1 (GRIK1) DMQXPA5 MT DTT DMQXPA5 MA Inhibitor DMQXPA5 RN Synthesis of chiral 1-(2'-amino-2'-carboxyethyl)-1,4-dihydro-6,7-quinoxaline-2,3-diones: alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate recep... J Med Chem. 1996 Oct 25;39(22):4430-8. DMQXPA5 RU https://pubmed.ncbi.nlm.nih.gov/8893837 DMQXPA5 DI DMQXPA5 DMQXPA5 DN DNQX DMQXPA5 MI TTLD29N DMQXPA5 MN Glutamate receptor ionotropic NMDA 1 (NMDAR1) DMQXPA5 MT DTT DMQXPA5 MA Inhibitor DMQXPA5 RN Kynurenic acid derivatives. Structure-activity relationships for excitatory amino acid antagonism and identification of potent and selective antago... J Med Chem. 1991 Apr;34(4):1243-52. DMQXPA5 RU https://pubmed.ncbi.nlm.nih.gov/1826744 DMQXPA5 DI DMQXPA5 DMQXPA5 DN DNQX DMQXPA5 MI TTKJEMQ DMQXPA5 MN Glutamate receptor ionotropic NMDA 2A (NMDAR2A) DMQXPA5 MT DTT DMQXPA5 MA Inhibitor DMQXPA5 RN Kynurenic acid derivatives. Structure-activity relationships for excitatory amino acid antagonism and identification of potent and selective antago... J Med Chem. 1991 Apr;34(4):1243-52. DMQXPA5 RU https://pubmed.ncbi.nlm.nih.gov/1826744 DMQXPA5 DI DMQXPA5 DMQXPA5 DN DNQX DMQXPA5 MI TTN9D8E DMQXPA5 MN Glutamate receptor ionotropic NMDA 2B (NMDAR2B) DMQXPA5 MT DTT DMQXPA5 MA Inhibitor DMQXPA5 RN Kynurenic acid derivatives. Structure-activity relationships for excitatory amino acid antagonism and identification of potent and selective antago... J Med Chem. 1991 Apr;34(4):1243-52. DMQXPA5 RU https://pubmed.ncbi.nlm.nih.gov/1826744 DMC5RL7 DI DMC5RL7 DMC5RL7 DN DNX-2000 DMC5RL7 MI TTOU65C DMC5RL7 MN Tyrosine-protein kinase SYK (SYK) DMC5RL7 MT DTT DMC5RL7 MA Inhibitor DMC5RL7 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2230). DMC5RL7 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2230 DMVCP6X DI DMVCP6X DMVCP6X DN Docosapentaenoic acid DMVCP6X MI TTSZLWK DMVCP6X MN Aromatase (CYP19A1) DMVCP6X MT DTT DMVCP6X MA Inhibitor DMVCP6X RN Interference by naturally occurring fatty acids in a noncellular enzyme-based aromatase bioassay. J Nat Prod. 2006 Apr;69(4):700-3. DMVCP6X RU https://pubmed.ncbi.nlm.nih.gov/16643058 DMEKU71 DI DMEKU71 DMEKU71 DN Dodeca-2E,4E-dienoic acid isobutylamide DMEKU71 MI TTMSFAW DMEKU71 MN Cannabinoid receptor 2 (CB2) DMEKU71 MT DTT DMEKU71 MA Inhibitor DMEKU71 RN Self-assembling cannabinomimetics: supramolecular structures of N-alkyl amides. J Nat Prod. 2007 Jun;70(6):1010-5. DMEKU71 RU https://pubmed.ncbi.nlm.nih.gov/17497806 DME9CGK DI DME9CGK DME9CGK DN Dodecane-1-sulfonyl fluoride DME9CGK MI TT6OEDT DME9CGK MN Cannabinoid receptor 1 (CB1) DME9CGK MT DTT DME9CGK MA Inhibitor DME9CGK RN Monoacylglycerol lipase regulates 2-arachidonoylglycerol action and arachidonic acid levels. Bioorg Med Chem Lett. 2008 Nov 15;18(22):5875-8. DME9CGK RU https://pubmed.ncbi.nlm.nih.gov/18752948 DME9CGK DI DME9CGK DME9CGK DN Dodecane-1-sulfonyl fluoride DME9CGK MI TTDP1UC DME9CGK MN Fatty acid amide hydrolase (FAAH) DME9CGK MT DTT DME9CGK MA Inhibitor DME9CGK RN Monoacylglycerol lipase regulates 2-arachidonoylglycerol action and arachidonic acid levels. Bioorg Med Chem Lett. 2008 Nov 15;18(22):5875-8. DME9CGK RU https://pubmed.ncbi.nlm.nih.gov/18752948 DMCNFEL DI DMCNFEL DMCNFEL DN Dodecanesulfonate ion DMCNFEL MI TTEB0GD DMCNFEL MN Cholinesterase (BCHE) DMCNFEL MT DTT DMCNFEL MA Inhibitor DMCNFEL RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DMCNFEL RU https://pubmed.ncbi.nlm.nih.gov/10592235 DMUPMCZ DI DMUPMCZ DMUPMCZ DN Dodecane-Trimethylamine DMUPMCZ MI TT7WUAV DMUPMCZ MN Protein-tyrosine phosphatase SHP-2 (PTPN11) DMUPMCZ MT DTT DMUPMCZ MA Inhibitor DMUPMCZ RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMUPMCZ RU https://pubmed.ncbi.nlm.nih.gov/17139284 DM6TIQX DI DM6TIQX DM6TIQX DN Dodecanoic acid adamantan-1-ylamide DM6TIQX MI TT7WVHI DM6TIQX MN Soluble epoxide hydrolase (EPHX2) DM6TIQX MT DTT DM6TIQX MA Inhibitor DM6TIQX RN Optimization of amide-based inhibitors of soluble epoxide hydrolase with improved water solubility. J Med Chem. 2005 May 19;48(10):3621-9. DM6TIQX RU https://pubmed.ncbi.nlm.nih.gov/15887969 DMMDG92 DI DMMDG92 DMMDG92 DN Dodecyl-Alpha-D-Maltoside DMMDG92 MI TT1Q3IE DMMDG92 MN Retinoic acid receptor gamma (RARG) DMMDG92 MT DTT DMMDG92 MA Inhibitor DMMDG92 RN DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Nucleic Acids Res. 2011 Jan;39(Database issue):D1035-41. DMMDG92 RU https://pubmed.ncbi.nlm.nih.gov/21059682 DMPCLTW DI DMPCLTW DMPCLTW DN dodecylphosphate DMPCLTW MI TTE2YJR DMPCLTW MN Lysophosphatidate-3 receptor (LPAR3) DMPCLTW MT DTT DMPCLTW MA Antagonist DMPCLTW RN Fatty alcohol phosphates are subtype-selective agonists and antagonists of lysophosphatidic acid receptors. Mol Pharmacol. 2003 May;63(5):1032-42. DMPCLTW RU https://pubmed.ncbi.nlm.nih.gov/12695531 DMPCLTW DI DMPCLTW DMPCLTW DN dodecylphosphate DMPCLTW MI TTB7Y8I DMPCLTW MN Lysophosphatidic acid receptor 2 (LPAR2) DMPCLTW MT DTT DMPCLTW MA Agonist DMPCLTW RN Fatty alcohol phosphates are subtype-selective agonists and antagonists of lysophosphatidic acid receptors. Mol Pharmacol. 2003 May;63(5):1032-42. DMPCLTW RU https://pubmed.ncbi.nlm.nih.gov/12695531 DMLHKI9 DI DMLHKI9 DMLHKI9 DN Dodecyl-phosphonic acid DMLHKI9 MI TTQ6S1K DMLHKI9 MN Lysophosphatidic acid receptor 1 (LPAR1) DMLHKI9 MT DTT DMLHKI9 MA Inhibitor DMLHKI9 RN Synthesis, structure-activity relationships, and biological evaluation of fatty alcohol phosphates as lysophosphatidic acid receptor ligands, activ... J Med Chem. 2005 Jul 28;48(15):4919-30. DMLHKI9 RU https://pubmed.ncbi.nlm.nih.gov/16033271 DMAJVPI DI DMAJVPI DMAJVPI DN dodecyl-thiophosphate DMAJVPI MI TTE2YJR DMAJVPI MN Lysophosphatidate-3 receptor (LPAR3) DMAJVPI MT DTT DMAJVPI MA Antagonist DMAJVPI RN Synthesis, structure-activity relationships, and biological evaluation of fatty alcohol phosphates as lysophosphatidic acid receptor ligands, activ... J Med Chem. 2005 Jul 28;48(15):4919-30. DMAJVPI RU https://pubmed.ncbi.nlm.nih.gov/16033271 DMAJVPI DI DMAJVPI DMAJVPI DN dodecyl-thiophosphate DMAJVPI MI TTQ6S1K DMAJVPI MN Lysophosphatidic acid receptor 1 (LPAR1) DMAJVPI MT DTT DMAJVPI MA Inhibitor DMAJVPI RN Synthesis, structure-activity relationships, and biological evaluation of fatty alcohol phosphates as lysophosphatidic acid receptor ligands, activ... J Med Chem. 2005 Jul 28;48(15):4919-30. DMAJVPI RU https://pubmed.ncbi.nlm.nih.gov/16033271 DMAJVPI DI DMAJVPI DMAJVPI DN dodecyl-thiophosphate DMAJVPI MI TTB7Y8I DMAJVPI MN Lysophosphatidic acid receptor 2 (LPAR2) DMAJVPI MT DTT DMAJVPI MA Agonist DMAJVPI RN Synthesis, structure-activity relationships, and biological evaluation of fatty alcohol phosphates as lysophosphatidic acid receptor ligands, activ... J Med Chem. 2005 Jul 28;48(15):4919-30. DMAJVPI RU https://pubmed.ncbi.nlm.nih.gov/16033271 DM1YCQF DI DM1YCQF DM1YCQF DN dolichol phosphate DM1YCQF MI TT5DFHW DM1YCQF MN Mevalonate kinase (MVK) DM1YCQF MT DTT DM1YCQF MA Inhibitor DM1YCQF RN Post-translational regulation of mevalonate kinase by intermediates of the cholesterol and nonsterol isoprene biosynthetic pathways. J Lipid Res. 1997 Nov;38(11):2216-23. DM1YCQF RU https://pubmed.ncbi.nlm.nih.gov/9392419 DM53KZX DI DM53KZX DM53KZX DN DOM DM53KZX MI TTJQOD7 DM53KZX MN 5-HT 2A receptor (HTR2A) DM53KZX MT DTT DM53KZX MA Inhibitor DM53KZX RN The role of lipophilicity in determining binding affinity and functional activity for 5-HT2A receptor ligands. Bioorg Med Chem. 2008 Apr 15;16(8):4661-9. DM53KZX RU https://pubmed.ncbi.nlm.nih.gov/18296055 DMXJOYH DI DMXJOYH DMXJOYH DN DOM-0215 DMXJOYH MI TTF8CQI DMXJOYH MN Tumor necrosis factor (TNF) DMXJOYH MT DTT DMXJOYH MA Modulator DMXJOYH RN The ChEMBL database in 2017. Nucleic Acids Res. 2017 Jan 4;45(D1):D945-D954. DMXJOYH RU https://www.ncbi.nlm.nih.gov/pubmed/27899562 DMYPVO0 DI DMYPVO0 DMYPVO0 DN domoic acid DMYPVO0 MI TT0MYE2 DMYPVO0 MN Glutamate receptor ionotropic kainate 1 (GRIK1) DMYPVO0 MT DTT DMYPVO0 MA Agonist DMYPVO0 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 450). DMYPVO0 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=450 DMYPVO0 DI DMYPVO0 DMYPVO0 DN domoic acid DMYPVO0 MI TT0K5RG DMYPVO0 MN Glutamate receptor ionotropic kainate 2 (GRIK2) DMYPVO0 MT DTT DMYPVO0 MA Agonist DMYPVO0 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 451). DMYPVO0 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=451 DMYPVO0 DI DMYPVO0 DMYPVO0 DN domoic acid DMYPVO0 MI TTQV6BO DMYPVO0 MN Glutamate receptor ionotropic kainate 4 (GluK4) DMYPVO0 MT DTT DMYPVO0 MA Agonist DMYPVO0 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 453). DMYPVO0 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=453 DMYPVO0 DI DMYPVO0 DMYPVO0 DN domoic acid DMYPVO0 MI TTO6LI7 DMYPVO0 MN Glutamate receptor ionotropic kainate 5 (GRIK5) DMYPVO0 MT DTT DMYPVO0 MA Agonist DMYPVO0 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 454). DMYPVO0 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=454 DMOJF6D DI DMOJF6D DMOJF6D DN Domoric acid DMOJF6D MI TT0MYE2 DMOJF6D MN Glutamate receptor ionotropic kainate 1 (GRIK1) DMOJF6D MT DTT DMOJF6D MA Inhibitor DMOJF6D RN Chemo-enzymatic synthesis of a series of 2,4-syn-functionalized (S)-glutamate analogues: new insight into the structure-activity relation of ionotr... J Med Chem. 2008 Jul 24;51(14):4093-103. DMOJF6D RU https://pubmed.ncbi.nlm.nih.gov/18578478 DMKYXJW DI DMKYXJW DMKYXJW DN Dorsomorphin DMKYXJW MI TTLAFZV DMKYXJW MN AMP-activated protein kinase (AMPK) DMKYXJW MT DTT DMKYXJW MA Inhibitor DMKYXJW RN The rational design of a novel potent analogue of the 5'-AMP-activated protein kinase inhibitor compound C with improved selectivity and cellular a... Bioorg Med Chem Lett. 2010 Nov 15;20(22):6394-9. DMKYXJW RU https://pubmed.ncbi.nlm.nih.gov/20932747 DM6TU84 DI DM6TU84 DM6TU84 DN Double Oxidized Cysteine DM6TU84 MI TTHCF4J DM6TU84 MN Alpha-glucosidase (GLA) DM6TU84 MT DTT DM6TU84 MA Inhibitor DM6TU84 RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DM6TU84 RU https://pubmed.ncbi.nlm.nih.gov/17139284 DM6TU84 DI DM6TU84 DM6TU84 DN Double Oxidized Cysteine DM6TU84 MI TTDS503 DM6TU84 MN Beta-crystallin B1 (CRYBB1) DM6TU84 MT DTT DM6TU84 MA Inhibitor DM6TU84 RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DM6TU84 RU https://pubmed.ncbi.nlm.nih.gov/17139284 DM6TU84 DI DM6TU84 DM6TU84 DN Double Oxidized Cysteine DM6TU84 MI TT7HF4W DM6TU84 MN Cyclin-dependent kinase 2 (CDK2) DM6TU84 MT DTT DM6TU84 MA Inhibitor DM6TU84 RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DM6TU84 RU https://pubmed.ncbi.nlm.nih.gov/17139284 DM6TU84 DI DM6TU84 DM6TU84 DN Double Oxidized Cysteine DM6TU84 MI TTXWASR DM6TU84 MN Intestinal maltase-glucoamylase (MGAM) DM6TU84 MT DTT DM6TU84 MA Inhibitor DM6TU84 RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DM6TU84 RU https://pubmed.ncbi.nlm.nih.gov/17139284 DM6TU84 DI DM6TU84 DM6TU84 DN Double Oxidized Cysteine DM6TU84 MI TTR0SWN DM6TU84 MN M-phase inducer phosphatase 2 (MPIP2) DM6TU84 MT DTT DM6TU84 MA Inhibitor DM6TU84 RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DM6TU84 RU https://pubmed.ncbi.nlm.nih.gov/17139284 DM6TU84 DI DM6TU84 DM6TU84 DN Double Oxidized Cysteine DM6TU84 MI TTNGKET DM6TU84 MN Prolyl endopeptidase (PREP) DM6TU84 MT DTT DM6TU84 MA Inhibitor DM6TU84 RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DM6TU84 RU https://pubmed.ncbi.nlm.nih.gov/17139284 DM6TU84 DI DM6TU84 DM6TU84 DN Double Oxidized Cysteine DM6TU84 MI TTELIN2 DM6TU84 MN PTPN1 messenger RNA (PTPN1 mRNA) DM6TU84 MT DTT DM6TU84 MA Inhibitor DM6TU84 RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DM6TU84 RU https://pubmed.ncbi.nlm.nih.gov/17139284 DM6TU84 DI DM6TU84 DM6TU84 DN Double Oxidized Cysteine DM6TU84 MI TTICO5G DM6TU84 MN Staphylococcus Peptide deformylase (Stap-coc def) DM6TU84 MT DTT DM6TU84 MA Inhibitor DM6TU84 RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DM6TU84 RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMQIK9S DI DMQIK9S DMQIK9S DN DOV-51892 DMQIK9S MI TTEX6LM DMQIK9S MN GABA(A) receptor gamma-3 (GABRG3) DMQIK9S MT DTT DMQIK9S MA Modulator DMQIK9S RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 415). DMQIK9S RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=415 DMJF6AQ DI DMJF6AQ DMJF6AQ DN Doxorubicin-Formaldehyde Conjugate DMJF6AQ MI TTZAYWL DMJF6AQ MN Estrogen receptor (ESR) DMJF6AQ MT DTT DMJF6AQ MA Inhibitor DMJF6AQ RN Design, synthesis, and biological evaluation of doxorubicin-formaldehyde conjugates targeted to breast cancer cells. J Med Chem. 2004 Feb 26;47(5):1193-206. DMJF6AQ RU https://pubmed.ncbi.nlm.nih.gov/14971899 DMJF6AQ DI DMJF6AQ DMJF6AQ DN Doxorubicin-Formaldehyde Conjugate DMJF6AQ MI TTOM3J0 DMJF6AQ MN Estrogen receptor beta (ESR2) DMJF6AQ MT DTT DMJF6AQ MA Inhibitor DMJF6AQ RN Design, synthesis, and biological evaluation of doxorubicin-formaldehyde conjugates targeted to breast cancer cells. J Med Chem. 2004 Feb 26;47(5):1193-206. DMJF6AQ RU https://pubmed.ncbi.nlm.nih.gov/14971899 DMNJBF8 DI DMNJBF8 DMNJBF8 DN doxorubicin-LL2 conjugate DMNJBF8 MI TT0IHXV DMNJBF8 MN DNA topoisomerase II (TOP2) DMNJBF8 MT DTT DMNJBF8 MA Modulator DMNJBF8 RN The ChEMBL database in 2017. Nucleic Acids Res. 2017 Jan 4;45(D1):D945-D954. DMNJBF8 RU https://www.ncbi.nlm.nih.gov/pubmed/27899562 DMNJBF8 DI DMNJBF8 DMNJBF8 DN doxorubicin-LL2 conjugate DMNJBF8 MI TTUTN1I DMNJBF8 MN Human Deoxyribonucleic acid (hDNA) DMNJBF8 MT DTT DMNJBF8 MA Modulator DMNJBF8 RN The ChEMBL database in 2017. Nucleic Acids Res. 2017 Jan 4;45(D1):D945-D954. DMNJBF8 RU https://www.ncbi.nlm.nih.gov/pubmed/27899562 DM2OCZ8 DI DM2OCZ8 DM2OCZ8 DN doxorubicin-peptide-PEG conjugate DM2OCZ8 MI TT0IHXV DM2OCZ8 MN DNA topoisomerase II (TOP2) DM2OCZ8 MT DTT DM2OCZ8 MA Modulator DM2OCZ8 RN The ChEMBL database in 2017. Nucleic Acids Res. 2017 Jan 4;45(D1):D945-D954. DM2OCZ8 RU https://www.ncbi.nlm.nih.gov/pubmed/27899562 DM2OCZ8 DI DM2OCZ8 DM2OCZ8 DN doxorubicin-peptide-PEG conjugate DM2OCZ8 MI TTUTN1I DM2OCZ8 MN Human Deoxyribonucleic acid (hDNA) DM2OCZ8 MT DTT DM2OCZ8 MA Modulator DM2OCZ8 RN The ChEMBL database in 2017. Nucleic Acids Res. 2017 Jan 4;45(D1):D945-D954. DM2OCZ8 RU https://www.ncbi.nlm.nih.gov/pubmed/27899562 DMXEVA2 DI DMXEVA2 DMXEVA2 DN DP-3005 DMXEVA2 MI TTZPWGN DMXEVA2 MN Voltage-gated calcium channel alpha Cav3.2 (CACNA1H) DMXEVA2 MT DTT DMXEVA2 MA Blocker DMXEVA2 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 536). DMXEVA2 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=536 DMFZML9 DI DMFZML9 DMFZML9 DN DP-3590 DMFZML9 MI TTNDSF4 DMFZML9 MN Proto-oncogene c-Met (MET) DMFZML9 MT DTT DMFZML9 MA Inhibitor DMFZML9 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1815). DMFZML9 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1815 DMARTC2 DI DMARTC2 DMARTC2 DN DP-802 DMARTC2 MI TTQBR95 DMARTC2 MN Stress-activated protein kinase 2a (p38 alpha) DMARTC2 MT DTT DMARTC2 MA Inhibitor DMARTC2 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1499). DMARTC2 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1499 DMIRSNA DI DMIRSNA DMIRSNA DN DPDPE DMIRSNA MI TT27RFC DMIRSNA MN Opioid receptor delta (OPRD1) DMIRSNA MT DTT DMIRSNA MA Inhibitor DMIRSNA RN Evaluation of N-substitution in 6,7-benzomorphan compounds. Bioorg Med Chem. 2010 Jul 15;18(14):4975-82. DMIRSNA RU https://pubmed.ncbi.nlm.nih.gov/20599386 DMIRSNA DI DMIRSNA DMIRSNA DN DPDPE DMIRSNA MI TTQW87Y DMIRSNA MN Opioid receptor kappa (OPRK1) DMIRSNA MT DTT DMIRSNA MA Inhibitor DMIRSNA RN Opioid agonist and antagonist activities of morphindoles related to naltrindole. J Med Chem. 1992 Nov 13;35(23):4325-9. DMIRSNA RU https://pubmed.ncbi.nlm.nih.gov/1333013 DMIRSNA DI DMIRSNA DMIRSNA DN DPDPE DMIRSNA MI TTKWM86 DMIRSNA MN Opioid receptor mu (MOP) DMIRSNA MT DTT DMIRSNA MA Inhibitor DMIRSNA RN Evaluation of N-substitution in 6,7-benzomorphan compounds. Bioorg Med Chem. 2010 Jul 15;18(14):4975-82. DMIRSNA RU https://pubmed.ncbi.nlm.nih.gov/20599386 DMLK428 DI DMLK428 DMLK428 DN D-Phe-Arg-2-Nal-NHCH3 DMLK428 MI TT0MV2T DMLK428 MN Melanocortin receptor 1 (MC1R) DMLK428 MT DTT DMLK428 MA Inhibitor DMLK428 RN Design, synthesis, and evaluation of proline and pyrrolidine based melanocortin receptor agonists. A conformationally restricted dipeptide mimic ap... J Med Chem. 2006 Jul 27;49(15):4745-61. DMLK428 RU https://pubmed.ncbi.nlm.nih.gov/16854081 DMLK428 DI DMLK428 DMLK428 DN D-Phe-Arg-2-Nal-NHCH3 DMLK428 MI TTD0CIQ DMLK428 MN Melanocortin receptor 4 (MC4R) DMLK428 MT DTT DMLK428 MA Inhibitor DMLK428 RN Design, synthesis, and evaluation of proline and pyrrolidine based melanocortin receptor agonists. A conformationally restricted dipeptide mimic ap... J Med Chem. 2006 Jul 27;49(15):4745-61. DMLK428 RU https://pubmed.ncbi.nlm.nih.gov/16854081 DM0YQHM DI DM0YQHM DM0YQHM DN D-Phe-c[Cys-Tyr-D-Trp-Lys-Val-Cys]-Asp-NH2 DM0YQHM MI TTZ6T9E DM0YQHM MN Somatostatin receptor type 2 (SSTR2) DM0YQHM MT DTT DM0YQHM MA Inhibitor DM0YQHM RN Discovery of iodinated somatostatin analogues selective for hsst2 and hsst5 with excellent inhibition of growth hormone and prolactin release from ... J Med Chem. 2005 Oct 20;48(21):6643-52. DM0YQHM RU https://pubmed.ncbi.nlm.nih.gov/16220980 DM0YQHM DI DM0YQHM DM0YQHM DN D-Phe-c[Cys-Tyr-D-Trp-Lys-Val-Cys]-Asp-NH2 DM0YQHM MI TT2BC4G DM0YQHM MN Somatostatin receptor type 5 (SSTR5) DM0YQHM MT DTT DM0YQHM MA Inhibitor DM0YQHM RN Discovery of iodinated somatostatin analogues selective for hsst2 and hsst5 with excellent inhibition of growth hormone and prolactin release from ... J Med Chem. 2005 Oct 20;48(21):6643-52. DM0YQHM RU https://pubmed.ncbi.nlm.nih.gov/16220980 DM2EFLA DI DM2EFLA DM2EFLA DN D-Phe-Cys-Tyr-D-Trp-Arg-Thr-Pen-Thr-NH2(CTAP) DM2EFLA MI TT27RFC DM2EFLA MN Opioid receptor delta (OPRD1) DM2EFLA MT DTT DM2EFLA MA Inhibitor DM2EFLA RN Design and synthesis of conformationally constrained somatostatin analogues with high potency and specificity for mu opioid receptors. J Med Chem. 1986 Nov;29(11):2370-5. DM2EFLA RU https://pubmed.ncbi.nlm.nih.gov/2878079 DM2EFLA DI DM2EFLA DM2EFLA DN D-Phe-Cys-Tyr-D-Trp-Arg-Thr-Pen-Thr-NH2(CTAP) DM2EFLA MI TTKWM86 DM2EFLA MN Opioid receptor mu (MOP) DM2EFLA MT DTT DM2EFLA MA Inhibitor DM2EFLA RN Design and synthesis of conformationally constrained somatostatin analogues with high potency and specificity for mu opioid receptors. J Med Chem. 1986 Nov;29(11):2370-5. DM2EFLA RU https://pubmed.ncbi.nlm.nih.gov/2878079 DMPQHRC DI DMPQHRC DMPQHRC DN D-Phe-Cys-Tyr-D-Trp-Lys-Thr-Pen-Thr-NH2(CTP) DMPQHRC MI TT27RFC DMPQHRC MN Opioid receptor delta (OPRD1) DMPQHRC MT DTT DMPQHRC MA Inhibitor DMPQHRC RN Design and synthesis of conformationally constrained somatostatin analogues with high potency and specificity for mu opioid receptors. J Med Chem. 1986 Nov;29(11):2370-5. DMPQHRC RU https://pubmed.ncbi.nlm.nih.gov/2878079 DMPQHRC DI DMPQHRC DMPQHRC DN D-Phe-Cys-Tyr-D-Trp-Lys-Thr-Pen-Thr-NH2(CTP) DMPQHRC MI TTKWM86 DMPQHRC MN Opioid receptor mu (MOP) DMPQHRC MT DTT DMPQHRC MA Inhibitor DMPQHRC RN Design and synthesis of conformationally constrained somatostatin analogues with high potency and specificity for mu opioid receptors. J Med Chem. 1986 Nov;29(11):2370-5. DMPQHRC RU https://pubmed.ncbi.nlm.nih.gov/2878079 DMX1IYO DI DMX1IYO DMX1IYO DN D-Phe-Cys-Tyr-D-Trp-Orn-Thr-Pen-Thr-NH2(CTOP) DMX1IYO MI TT27RFC DMX1IYO MN Opioid receptor delta (OPRD1) DMX1IYO MT DTT DMX1IYO MA Inhibitor DMX1IYO RN Design and synthesis of conformationally constrained somatostatin analogues with high potency and specificity for mu opioid receptors. J Med Chem. 1986 Nov;29(11):2370-5. DMX1IYO RU https://pubmed.ncbi.nlm.nih.gov/2878079 DMUJC97 DI DMUJC97 DMUJC97 DN D-Phe-Cys-Tyr--Trp-Lys-Thr-Pen-Thr-NH2 DMUJC97 MI TTKWM86 DMUJC97 MN Opioid receptor mu (MOP) DMUJC97 MT DTT DMUJC97 MA Inhibitor DMUJC97 RN Design and synthesis of conformationally constrained somatostatin analogues with high potency and specificity for mu opioid receptors. J Med Chem. 1986 Nov;29(11):2370-5. DMUJC97 RU https://pubmed.ncbi.nlm.nih.gov/2878079 DMTUHFX DI DMTUHFX DMTUHFX DN D-Phenylalanine DMTUHFX MI TTA7YIZ DMTUHFX MN Corticoliberin (CRH) DMTUHFX MT DTT DMTUHFX MA Inhibitor DMTUHFX RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMTUHFX RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMGD7JM DI DMGD7JM DMGD7JM DN D-phenylalanyl-N-(3-chlorobenzyl)-L-prolinamide DMGD7JM MI TT6L509 DMGD7JM MN Coagulation factor IIa (F2) DMGD7JM MT DTT DMGD7JM MA Inhibitor DMGD7JM RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DMGD7JM RU https://pubmed.ncbi.nlm.nih.gov/10592235 DM5XHA6 DI DM5XHA6 DM5XHA6 DN D-phenylalanyl-N-(3-fluorobenzyl)-L-prolinamide DM5XHA6 MI TT6L509 DM5XHA6 MN Coagulation factor IIa (F2) DM5XHA6 MT DTT DM5XHA6 MA Inhibitor DM5XHA6 RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DM5XHA6 RU https://pubmed.ncbi.nlm.nih.gov/10592235 DMV9RAN DI DMV9RAN DMV9RAN DN D-phenylalanyl-N-(3-methylbenzyl)-L-prolinamide DMV9RAN MI TT6L509 DMV9RAN MN Coagulation factor IIa (F2) DMV9RAN MT DTT DMV9RAN MA Inhibitor DMV9RAN RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DMV9RAN RU https://pubmed.ncbi.nlm.nih.gov/10592235 DMHNR63 DI DMHNR63 DMHNR63 DN D-phenylalanyl-N-benzyl-L-prolinamide DMHNR63 MI TT6L509 DMHNR63 MN Coagulation factor IIa (F2) DMHNR63 MT DTT DMHNR63 MA Inhibitor DMHNR63 RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DMHNR63 RU https://pubmed.ncbi.nlm.nih.gov/10592235 DMMXA5K DI DMMXA5K DMMXA5K DN D-PhGly-Cys-Tyr-D-Trp-Lys-Thr-Pen-Thr-NH2 DMMXA5K MI TT27RFC DMMXA5K MN Opioid receptor delta (OPRD1) DMMXA5K MT DTT DMMXA5K MA Inhibitor DMMXA5K RN Design and synthesis of conformationally constrained somatostatin analogues with high potency and specificity for mu opioid receptors. J Med Chem. 1986 Nov;29(11):2370-5. DMMXA5K RU https://pubmed.ncbi.nlm.nih.gov/2878079 DMMXA5K DI DMMXA5K DMMXA5K DN D-PhGly-Cys-Tyr-D-Trp-Lys-Thr-Pen-Thr-NH2 DMMXA5K MI TTKWM86 DMMXA5K MN Opioid receptor mu (MOP) DMMXA5K MT DTT DMMXA5K MA Inhibitor DMMXA5K RN Design and synthesis of conformationally constrained somatostatin analogues with high potency and specificity for mu opioid receptors. J Med Chem. 1986 Nov;29(11):2370-5. DMMXA5K RU https://pubmed.ncbi.nlm.nih.gov/2878079 DME5S3C DI DME5S3C DME5S3C DN DPI-221 DME5S3C MI TT27RFC DME5S3C MN Opioid receptor delta (OPRD1) DME5S3C MT DTT DME5S3C MA Agonist DME5S3C RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 317). DME5S3C RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=317 DMTHZ3B DI DMTHZ3B DMTHZ3B DN DPI59 DMTHZ3B MI TT6PKBN DMTHZ3B MN Proto-oncogene c-Src (SRC) DMTHZ3B MT DTT DMTHZ3B MA Inhibitor DMTHZ3B RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DMTHZ3B RU https://pubmed.ncbi.nlm.nih.gov/10592235 DMSRUKQ DI DMSRUKQ DMSRUKQ DN DPN-205-734 DMSRUKQ MI TTUST1O DMSRUKQ MN Phosphodiesterase (PDE) DMSRUKQ MT DTT DMSRUKQ MA Inhibitor DMSRUKQ RN Pharmacological actions of DPN 205-734, a novel cardiotonic agent. J Cardiovasc Pharmacol. 1988 Oct;12(4):451-60. DMSRUKQ RU https://pubmed.ncbi.nlm.nih.gov/2465446 DMHCZP0 DI DMHCZP0 DMHCZP0 DN DPO-1 DMHCZP0 MI TTW0CMT DMHCZP0 MN Voltage-gated potassium channel Kv1.5 (KCNA5) DMHCZP0 MT DTT DMHCZP0 MA Antagonist DMHCZP0 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 542). DMHCZP0 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=542 DMRJQ8X DI DMRJQ8X DMRJQ8X DN D-Pro-Phe-Arg chloromethyl ketone DMRJQ8X MI TT6L509 DMRJQ8X MN Coagulation factor IIa (F2) DMRJQ8X MT DTT DMRJQ8X MA Inhibitor DMRJQ8X RN Novel 3-carboxamide-coumarins as potent and selective FXIIa inhibitors. J Med Chem. 2008 Jun 12;51(11):3077-80. DMRJQ8X RU https://pubmed.ncbi.nlm.nih.gov/18459730 DMRJQ8X DI DMRJQ8X DMRJQ8X DN D-Pro-Phe-Arg chloromethyl ketone DMRJQ8X MI TTCIHJA DMRJQ8X MN Coagulation factor Xa (F10) DMRJQ8X MT DTT DMRJQ8X MA Inhibitor DMRJQ8X RN Novel 3-carboxamide-coumarins as potent and selective FXIIa inhibitors. J Med Chem. 2008 Jun 12;51(11):3077-80. DMRJQ8X RU https://pubmed.ncbi.nlm.nih.gov/18459730 DMRJQ8X DI DMRJQ8X DMRJQ8X DN D-Pro-Phe-Arg chloromethyl ketone DMRJQ8X MI TTMF8H9 DMRJQ8X MN Plasma kallikrein (KLKB1) DMRJQ8X MT DTT DMRJQ8X MA Inhibitor DMRJQ8X RN Novel 3-carboxamide-coumarins as potent and selective FXIIa inhibitors. J Med Chem. 2008 Jun 12;51(11):3077-80. DMRJQ8X RU https://pubmed.ncbi.nlm.nih.gov/18459730 DMRJQ8X DI DMRJQ8X DMRJQ8X DN D-Pro-Phe-Arg chloromethyl ketone DMRJQ8X MI TT38MDJ DMRJQ8X MN Tissue factor (F3) DMRJQ8X MT DTT DMRJQ8X MA Inhibitor DMRJQ8X RN Novel 3-carboxamide-coumarins as potent and selective FXIIa inhibitors. J Med Chem. 2008 Jun 12;51(11):3077-80. DMRJQ8X RU https://pubmed.ncbi.nlm.nih.gov/18459730 DM35CKE DI DM35CKE DM35CKE DN DprwFwLL-NH2 DM35CKE MI TTWDC17 DM35CKE MN Growth hormone secretagogue receptor 1 (GHSR) DM35CKE MT DTT DM35CKE MA Inhibitor DM35CKE RN Identification of an efficacy switch region in the ghrelin receptor responsible for interchange between agonism and inverse agonism. J Biol Chem. 2007 May 25;282(21):15799-811. DM35CKE RU https://pubmed.ncbi.nlm.nih.gov/17371869 DMQLJ3Y DI DMQLJ3Y DMQLJ3Y DN DQP-1105 DMQLJ3Y MI TTN9D8E DMQLJ3Y MN Glutamate receptor ionotropic NMDA 2B (NMDAR2B) DMQLJ3Y MT DTT DMQLJ3Y MA Modulator (allosteric modulator) DMQLJ3Y RN Mechanism for noncompetitive inhibition by novel GluN2C/D N-methyl-D-aspartate receptor subunit-selective modulators. Mol Pharmacol. 2011 Nov;80(5):782-95. DMQLJ3Y RU https://pubmed.ncbi.nlm.nih.gov/21807990 DMQLJ3Y DI DMQLJ3Y DMQLJ3Y DN DQP-1105 DMQLJ3Y MI TT1M8OW DMQLJ3Y MN Glutamate receptor ionotropic NMDA 2C (GluN2C) DMQLJ3Y MT DTT DMQLJ3Y MA Modulator (allosteric modulator) DMQLJ3Y RN Mechanism for noncompetitive inhibition by novel GluN2C/D N-methyl-D-aspartate receptor subunit-selective modulators. Mol Pharmacol. 2011 Nov;80(5):782-95. DMQLJ3Y RU https://pubmed.ncbi.nlm.nih.gov/21807990 DMQLJ3Y DI DMQLJ3Y DMQLJ3Y DN DQP-1105 DMQLJ3Y MI TT5POTG DMQLJ3Y MN Glutamate receptor ionotropic NMDA 2D (GluN2D) DMQLJ3Y MT DTT DMQLJ3Y MA Modulator (allosteric modulator) DMQLJ3Y RN Mechanism for noncompetitive inhibition by novel GluN2C/D N-methyl-D-aspartate receptor subunit-selective modulators. Mol Pharmacol. 2011 Nov;80(5):782-95. DMQLJ3Y RU https://pubmed.ncbi.nlm.nih.gov/21807990 DM1AV5R DI DM1AV5R DM1AV5R DN DR2313 DM1AV5R MI TTVDSZ0 DM1AV5R MN Poly [ADP-ribose] polymerase 1 (PARP1) DM1AV5R MT DTT DM1AV5R MA Inhibitor DM1AV5R RN Poly(ADP-ribose) polymerase and the therapeutic effects of its inhibitors. Nat Rev Drug Discov. 2005 May;4(5):421-40. DM1AV5R RU https://pubmed.ncbi.nlm.nih.gov/15864271 DMW8ORN DI DMW8ORN DMW8ORN DN DR-4004 DMW8ORN MI TTO9X1H DMW8ORN MN 5-HT 7 receptor (HTR7) DMW8ORN MT DTT DMW8ORN MA Antagonist DMW8ORN RN Higher-end serotonin receptors: 5-HT(5), 5-HT(6), and 5-HT(7). J Med Chem. 2003 Jul 3;46(14):2795-812. DMW8ORN RU https://pubmed.ncbi.nlm.nih.gov/12825922 DMX2TZD DI DMX2TZD DMX2TZD DN DR-5/DR-4 cross reactive mabs DMX2TZD MI TT5WLRX DMX2TZD MN TRAIL receptor 1 (TRAIL-R1) DMX2TZD MT DTT DMX2TZD RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1879). DMX2TZD RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1879 DMX2TZD DI DMX2TZD DMX2TZD DN DR-5/DR-4 cross reactive mabs DMX2TZD MI TTW20TU DMX2TZD MN TRAIL receptor 2 (TRAIL-R2) DMX2TZD MT DTT DMX2TZD RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1880). DMX2TZD RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1880 DMTFQG3 DI DMTFQG3 DMTFQG3 DN DRF 2519 DMTFQG3 MI TTJ584C DMTFQG3 MN Peroxisome proliferator-activated receptor alpha (PPARA) DMTFQG3 MT DTT DMTFQG3 MA Agonist DMTFQG3 RN Antidiabetic and hypolipidemic potential of DRF 2519--a dual activator of PPAR-alpha and PPAR-gamma. Eur J Pharmacol. 2004 May 3;491(2-3):195-206. DMTFQG3 RU https://pubmed.ncbi.nlm.nih.gov/15140637 DMTFQG3 DI DMTFQG3 DMTFQG3 DN DRF 2519 DMTFQG3 MI TTT2SVW DMTFQG3 MN PPAR-gamma messenger RNA (PPARG mRNA) DMTFQG3 MT DTT DMTFQG3 MA Agonist DMTFQG3 RN Antidiabetic and hypolipidemic potential of DRF 2519--a dual activator of PPAR-alpha and PPAR-gamma. Eur J Pharmacol. 2004 May 3;491(2-3):195-206. DMTFQG3 RU https://pubmed.ncbi.nlm.nih.gov/15140637 DMYOLEV DI DMYOLEV DMYOLEV DN D-ribosylnicotinate DMYOLEV MI DENV24I DMYOLEV MN Nicotinamide riboside kinase 1 (NRK1) DMYOLEV MT DME DMYOLEV MA Metabolism DMYOLEV RN Nicotinamide riboside kinase structures reveal new pathways to NAD+. PLoS Biol. 2007 Oct 2;5(10):e263. DMYOLEV RU https://www.ncbi.nlm.nih.gov/pubmed/?term=17914902 DMYOLEV DI DMYOLEV DMYOLEV DN D-ribosylnicotinate DMYOLEV MI DE8DJ3N DMYOLEV MN Nicotinamide riboside kinase 2 (NRK2) DMYOLEV MT DME DMYOLEV MA Metabolism DMYOLEV RN Nicotinamide riboside kinase structures reveal new pathways to NAD+. PLoS Biol. 2007 Oct 2;5(10):e263. DMYOLEV RU https://www.ncbi.nlm.nih.gov/pubmed/?term=17914902 DM5IA9W DI DM5IA9W DM5IA9W DN droxinostat DM5IA9W MI TT4YWTO DM5IA9W MN Histone deacetylase 3 (HDAC3) DM5IA9W MT DTT DM5IA9W MA Inhibitor DM5IA9W RN Selective inhibition of histone deacetylases sensitizes malignant cells to death receptor ligands. Mol Cancer Ther. 2010 Jan;9(1):246-56. DM5IA9W RU https://pubmed.ncbi.nlm.nih.gov/20053768 DM5IA9W DI DM5IA9W DM5IA9W DN droxinostat DM5IA9W MI TT5ZKDI DM5IA9W MN Histone deacetylase 6 (HDAC6) DM5IA9W MT DTT DM5IA9W MA Inhibitor DM5IA9W RN Selective inhibition of histone deacetylases sensitizes malignant cells to death receptor ligands. Mol Cancer Ther. 2010 Jan;9(1):246-56. DM5IA9W RU https://pubmed.ncbi.nlm.nih.gov/20053768 DM5IA9W DI DM5IA9W DM5IA9W DN droxinostat DM5IA9W MI TTT6LFV DM5IA9W MN Histone deacetylase 8 (HDAC8) DM5IA9W MT DTT DM5IA9W MA Inhibitor DM5IA9W RN Selective inhibition of histone deacetylases sensitizes malignant cells to death receptor ligands. Mol Cancer Ther. 2010 Jan;9(1):246-56. DM5IA9W RU https://pubmed.ncbi.nlm.nih.gov/20053768 DMBUH02 DI DMBUH02 DMBUH02 DN DRP-049 DMBUH02 MI TTP4520 DMBUH02 MN TGF-beta receptor type I (TGFBR1) DMBUH02 MT DTT DMBUH02 MA Inhibitor DMBUH02 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1788). DMBUH02 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1788 DM5QUJV DI DM5QUJV DM5QUJV DN Drug 311383 DM5QUJV MI TT9W8GU DM5QUJV MN Gamma-secretase (GS) DM5QUJV MT DTT DM5QUJV MA Inhibitor DM5QUJV RN Discovery of a Subnanomolar helical D-tridecapeptide inhibitor of gamma-secretase. J Med Chem. 2004 Jul 29;47(16):3931-3. DM5QUJV RU https://pubmed.ncbi.nlm.nih.gov/15267231 DM5QUJV DI DM5QUJV DM5QUJV DN Drug 311383 DM5QUJV MI TTZ3S8C DM5QUJV MN Presenilin 1 (PSEN1) DM5QUJV MT DTT DM5QUJV MA Inhibitor DM5QUJV RN Discovery of a Subnanomolar helical D-tridecapeptide inhibitor of gamma-secretase. J Med Chem. 2004 Jul 29;47(16):3931-3. DM5QUJV RU https://pubmed.ncbi.nlm.nih.gov/15267231 DM5QUJV DI DM5QUJV DM5QUJV DN Drug 311383 DM5QUJV MI TTWN3F4 DM5QUJV MN Presenilin 2 (PSEN2) DM5QUJV MT DTT DM5QUJV MA Inhibitor DM5QUJV RN Discovery of a Subnanomolar helical D-tridecapeptide inhibitor of gamma-secretase. J Med Chem. 2004 Jul 29;47(16):3931-3. DM5QUJV RU https://pubmed.ncbi.nlm.nih.gov/15267231 DMOIFBK DI DMOIFBK DMOIFBK DN Drug 311440 DMOIFBK MI TT9W8GU DMOIFBK MN Gamma-secretase (GS) DMOIFBK MT DTT DMOIFBK MA Inhibitor DMOIFBK RN Discovery of a Subnanomolar helical D-tridecapeptide inhibitor of gamma-secretase. J Med Chem. 2004 Jul 29;47(16):3931-3. DMOIFBK RU https://pubmed.ncbi.nlm.nih.gov/15267231 DMOIFBK DI DMOIFBK DMOIFBK DN Drug 311440 DMOIFBK MI TTZ3S8C DMOIFBK MN Presenilin 1 (PSEN1) DMOIFBK MT DTT DMOIFBK MA Inhibitor DMOIFBK RN Discovery of a Subnanomolar helical D-tridecapeptide inhibitor of gamma-secretase. J Med Chem. 2004 Jul 29;47(16):3931-3. DMOIFBK RU https://pubmed.ncbi.nlm.nih.gov/15267231 DMOIFBK DI DMOIFBK DMOIFBK DN Drug 311440 DMOIFBK MI TTWN3F4 DMOIFBK MN Presenilin 2 (PSEN2) DMOIFBK MT DTT DMOIFBK MA Inhibitor DMOIFBK RN Discovery of a Subnanomolar helical D-tridecapeptide inhibitor of gamma-secretase. J Med Chem. 2004 Jul 29;47(16):3931-3. DMOIFBK RU https://pubmed.ncbi.nlm.nih.gov/15267231 DMXTCJ1 DI DMXTCJ1 DMXTCJ1 DN Drug 311951 DMXTCJ1 MI TT9W8GU DMXTCJ1 MN Gamma-secretase (GS) DMXTCJ1 MT DTT DMXTCJ1 MA Inhibitor DMXTCJ1 RN Discovery of a Subnanomolar helical D-tridecapeptide inhibitor of gamma-secretase. J Med Chem. 2004 Jul 29;47(16):3931-3. DMXTCJ1 RU https://pubmed.ncbi.nlm.nih.gov/15267231 DMXTCJ1 DI DMXTCJ1 DMXTCJ1 DN Drug 311951 DMXTCJ1 MI TTZ3S8C DMXTCJ1 MN Presenilin 1 (PSEN1) DMXTCJ1 MT DTT DMXTCJ1 MA Inhibitor DMXTCJ1 RN Discovery of a Subnanomolar helical D-tridecapeptide inhibitor of gamma-secretase. J Med Chem. 2004 Jul 29;47(16):3931-3. DMXTCJ1 RU https://pubmed.ncbi.nlm.nih.gov/15267231 DMXTCJ1 DI DMXTCJ1 DMXTCJ1 DN Drug 311951 DMXTCJ1 MI TTWN3F4 DMXTCJ1 MN Presenilin 2 (PSEN2) DMXTCJ1 MT DTT DMXTCJ1 MA Inhibitor DMXTCJ1 RN Discovery of a Subnanomolar helical D-tridecapeptide inhibitor of gamma-secretase. J Med Chem. 2004 Jul 29;47(16):3931-3. DMXTCJ1 RU https://pubmed.ncbi.nlm.nih.gov/15267231 DM27ILS DI DM27ILS DM27ILS DN Drug 311952 DM27ILS MI TT9W8GU DM27ILS MN Gamma-secretase (GS) DM27ILS MT DTT DM27ILS MA Inhibitor DM27ILS RN Discovery of a Subnanomolar helical D-tridecapeptide inhibitor of gamma-secretase. J Med Chem. 2004 Jul 29;47(16):3931-3. DM27ILS RU https://pubmed.ncbi.nlm.nih.gov/15267231 DM27ILS DI DM27ILS DM27ILS DN Drug 311952 DM27ILS MI TTZ3S8C DM27ILS MN Presenilin 1 (PSEN1) DM27ILS MT DTT DM27ILS MA Inhibitor DM27ILS RN Discovery of a Subnanomolar helical D-tridecapeptide inhibitor of gamma-secretase. J Med Chem. 2004 Jul 29;47(16):3931-3. DM27ILS RU https://pubmed.ncbi.nlm.nih.gov/15267231 DM27ILS DI DM27ILS DM27ILS DN Drug 311952 DM27ILS MI TTWN3F4 DM27ILS MN Presenilin 2 (PSEN2) DM27ILS MT DTT DM27ILS MA Inhibitor DM27ILS RN Discovery of a Subnanomolar helical D-tridecapeptide inhibitor of gamma-secretase. J Med Chem. 2004 Jul 29;47(16):3931-3. DM27ILS RU https://pubmed.ncbi.nlm.nih.gov/15267231 DML4V73 DI DML4V73 DML4V73 DN Drug 7684380 DML4V73 MI TTQW87Y DML4V73 MN Opioid receptor kappa (OPRK1) DML4V73 MT DTT DML4V73 MA Antagonist DML4V73 RN FK-506-binding protein: three-dimensional structure of the complex with the antagonist L-685,818. J Biol Chem. 1993 May 25;268(15):11335-9. DML4V73 RU https://pubmed.ncbi.nlm.nih.gov/7684380 DME3WBQ DI DME3WBQ DME3WBQ DN DS-437 DME3WBQ MI TTR1D7X DME3WBQ MN Protein arginine methyltransferase 5 (PRMT5) DME3WBQ MT DTT DME3WBQ MA Inhibitor DME3WBQ RN Discovery of a Dual PRMT5-PRMT7 Inhibitor. ACS Med Chem Lett. 2015 Mar 2;6(4):408-12. DME3WBQ RU https://pubmed.ncbi.nlm.nih.gov/25893041 DME3WBQ DI DME3WBQ DME3WBQ DN DS-437 DME3WBQ MI TTAR2P0 DME3WBQ MN Protein arginine methyltransferase 7 (PRMT7) DME3WBQ MT DTT DME3WBQ MA Inhibitor DME3WBQ RN Discovery of a Dual PRMT5-PRMT7 Inhibitor. ACS Med Chem Lett. 2015 Mar 2;6(4):408-12. DME3WBQ RU https://pubmed.ncbi.nlm.nih.gov/25893041 DMZGWQA DI DMZGWQA DMZGWQA DN DS-AH-14 DMZGWQA MI TTOXS3C DMZGWQA MN Muscarinic acetylcholine receptor (CHRM) DMZGWQA MT DTT DMZGWQA MA Modulator DMZGWQA RN US patent application no. 5,446,057, Substituted tetrahydropyridine and piperidine carboxylic acids as muscarinic antagonists. DMZGWQA RU http://www.google.com/patents/US5446057 DMSTOB0 DI DMSTOB0 DMSTOB0 DN DSLET DMSTOB0 MI TT27RFC DMSTOB0 MN Opioid receptor delta (OPRD1) DMSTOB0 MT DTT DMSTOB0 MA Agonist DMSTOB0 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 317). DMSTOB0 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=317 DMSTOB0 DI DMSTOB0 DMSTOB0 DN DSLET DMSTOB0 MI TTKWM86 DMSTOB0 MN Opioid receptor mu (MOP) DMSTOB0 MT DTT DMSTOB0 MA Agonist DMSTOB0 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 319). DMSTOB0 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=319 DM1LK0C DI DM1LK0C DM1LK0C DN DSM1 DM1LK0C MI TT3PQ2Y DM1LK0C MN Plasmodium Dihydroorotate dehydrogenase (Malaria DHOdehase) DM1LK0C MT DTT DM1LK0C MA Inhibitor DM1LK0C RN Plasmodium dihydroorotate dehydrogenase: a promising target for novel anti-malarial chemotherapy. Infect Disord Drug Targets. 2010 Jun;10(3):226-39. DM1LK0C RU https://pubmed.ncbi.nlm.nih.gov/20334617 DMZYQOB DI DMZYQOB DMZYQOB DN DSM2 DMZYQOB MI TT3PQ2Y DMZYQOB MN Plasmodium Dihydroorotate dehydrogenase (Malaria DHOdehase) DMZYQOB MT DTT DMZYQOB MA Inhibitor DMZYQOB RN Plasmodium dihydroorotate dehydrogenase: a promising target for novel anti-malarial chemotherapy. Infect Disord Drug Targets. 2010 Jun;10(3):226-39. DMZYQOB RU https://pubmed.ncbi.nlm.nih.gov/20334617 DM4EKHR DI DM4EKHR DM4EKHR DN DSR-17759 DM4EKHR MI TT9O6WS DM4EKHR MN Glucagon receptor (GCGR) DM4EKHR MT DTT DM4EKHR MA Antagonist DM4EKHR RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 251). DM4EKHR RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=251 DMSVP1K DI DMSVP1K DMSVP1K DN DSTBULET DMSVP1K MI TT27RFC DMSVP1K MN Opioid receptor delta (OPRD1) DMSVP1K MT DTT DMSVP1K MA Agonist DMSVP1K RN [3H][D-Ser2(O-tert-butyl),Leu5]enkephalyl-Thr6 and [D-Ser2(O-tert-butyl),Leu5]enkephalyl-Thr6(O-tert-butyl). Two new enkephalin analogs with both a good selectivity and a high affinity toward delta-opioid binding sites. J Biol Chem. 1988 Mar 25;263(9):4124-30. DMSVP1K RU https://pubmed.ncbi.nlm.nih.gov/2831220 DMCKQF7 DI DMCKQF7 DMCKQF7 DN DT-2228 DMCKQF7 MI TTXJ47W DMCKQF7 MN Metabotropic glutamate receptor 2 (mGluR2) DMCKQF7 MT DTT DMCKQF7 MA Modulator DMCKQF7 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 290). DMCKQF7 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=290 DM3TMUK DI DM3TMUK DM3TMUK DN DT-831j DM3TMUK MI TTCIHJA DM3TMUK MN Coagulation factor Xa (F10) DM3TMUK MT DTT DM3TMUK MA Antagonist DM3TMUK RN Semuloparin for the prevention of venous thromboembolic events in cancer patients. Drugs Today (Barc). 2012 Jul;48(7):451-7. DM3TMUK RU https://pubmed.ncbi.nlm.nih.gov/22844656 DM376J2 DI DM376J2 DM376J2 DN D-tartaric acid DM376J2 MI TTHZQP0 DM376J2 MN Triggering receptor expressed on monocytes 1 (TREM1) DM376J2 MT DTT DM376J2 MA Inhibitor DM376J2 RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DM376J2 RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMPKTB4 DI DMPKTB4 DMPKTB4 DN DTD DMPKTB4 MI TTSXVID DMPKTB4 MN Nuclear factor NF-kappa-B (NFKB) DMPKTB4 MT DTT DMPKTB4 MA Inhibitor DMPKTB4 RN A new ditriazine inhibitor of NF-kappaB modulates chronic inflammation and angiogenesis. Naunyn Schmiedebergs Arch Pharmacol. 2002 May;365(5):357-64. DMPKTB4 RU https://pubmed.ncbi.nlm.nih.gov/12012021 DMNS265 DI DMNS265 DMNS265 DN DTPA Conjugate DMNS265 MI TTN53ZF DMNS265 MN Leukotriene B4 receptor 1 (LTB4R) DMNS265 MT DTT DMNS265 MA Inhibitor DMNS265 RN Synthesis of leukotriene B4 antagonists labeled with In-111 or Tc-99m to image infectious and inflammatory foci. J Med Chem. 2005 Oct 6;48(20):6442-53. DMNS265 RU https://pubmed.ncbi.nlm.nih.gov/16190770 DM1JL5W DI DM1JL5W DM1JL5W DN D-Trp8-SRIF-14 DM1JL5W MI TTAE1BR DM1JL5W MN Somatostatin receptor type 4 (SSTR4) DM1JL5W MT DTT DM1JL5W MA Inhibitor DM1JL5W RN Replacement of Phe6, Phe7, and Phe11 of D-Trp8-somatostatin-14 with L-pyrazinylalanine. Predicted and observed effects on binding affinities at hSS... J Med Chem. 2005 Jun 16;48(12):4025-30. DM1JL5W RU https://pubmed.ncbi.nlm.nih.gov/15943475 DMKIML1 DI DMKIML1 DMKIML1 DN D-tryptophan DMKIML1 MI TT8WFXV DMKIML1 MN Hydroxycarboxylic acid receptor 3 (HCAR3) DMKIML1 MT DTT DMKIML1 MA Agonist DMKIML1 RN Aromatic D-amino acids act as chemoattractant factors for human leukocytes through a G protein-coupled receptor, GPR109B. Proc Natl Acad Sci U S A. 2009 Mar 10;106(10):3930-4. DMKIML1 RU https://pubmed.ncbi.nlm.nih.gov/19237584 DM7PNOK DI DM7PNOK DM7PNOK DN DTS-108 DM7PNOK MI TTGTQHC DM7PNOK MN DNA topoisomerase I (TOP1) DM7PNOK MT DTT DM7PNOK MA Inhibitor DM7PNOK RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2636). DM7PNOK RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2636 DMUKPO3 DI DMUKPO3 DMUKPO3 DN Duo3 DMUKPO3 MI TTOXS3C DMUKPO3 MN Muscarinic acetylcholine receptor (CHRM) DMUKPO3 MT DTT DMUKPO3 MA Modulator (allosteric modulator) DMUKPO3 RN Atypical muscarinic allosteric modulation: cooperativity between modulators and their atypical binding topology in muscarinic M2 and M2/M5 chimeric... Mol Pharmacol. 2005 Dec;68(6):1597-610. DMUKPO3 RU https://pubmed.ncbi.nlm.nih.gov/16157694 DM0CQIP DI DM0CQIP DM0CQIP DN Duocarmycin DM0CQIP MI TTOVXHF DM0CQIP MN Human Deoxyribonucleic acid minor groove (hDNA min) DM0CQIP MT DTT DM0CQIP MA Breaker DM0CQIP RN Structural studies of atom-specific anticancer drugs acting on DNA. Pharmacol Ther. 1999 Sep;83(3):181-215. DM0CQIP RU https://pubmed.ncbi.nlm.nih.gov/10576292 DM29PTO DI DM29PTO DM29PTO DN Durhamycin A DM29PTO MI TTT3ZC9 DM29PTO MN Human immunodeficiency virus Tat protein (HIV tat) DM29PTO MT DTT DM29PTO MA Inhibitor DM29PTO RN Durhamycin A, a potent inhibitor of HIV Tat transactivation. J Nat Prod. 2002 Aug;65(8):1091-5. DM29PTO RU https://pubmed.ncbi.nlm.nih.gov/12193009 DML7YPS DI DML7YPS DML7YPS DN Duroquinone DML7YPS MI TT8XK6L DML7YPS MN Quinone reductase 1 (NQO1) DML7YPS MT DTT DML7YPS MA Inhibitor DML7YPS RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DML7YPS RU https://pubmed.ncbi.nlm.nih.gov/17139284 DML4G6K DI DML4G6K DML4G6K DN D-Val-L-boroPro DML4G6K MI TTDIGC1 DML4G6K MN Dipeptidyl peptidase 4 (DPP-4) DML4G6K MT DTT DML4G6K MA Inhibitor DML4G6K RN Synthesis and characterization of constrained peptidomimetic dipeptidyl peptidase IV inhibitors: amino-lactam boroalanines. J Med Chem. 2007 May 17;50(10):2391-8. DML4G6K RU https://pubmed.ncbi.nlm.nih.gov/17458948 DM53079 DI DM53079 DM53079 DN DVDAVP DM53079 MI TT4TFGN DM53079 MN Vasopressin V1a receptor (V1AR) DM53079 MT DTT DM53079 MA Inhibitor DM53079 RN Design and synthesis of the first selective agonists for the rat vasopressin V(1b) receptor: based on modifications of deamino-[Cys1]arginine vasop... J Med Chem. 2007 Feb 22;50(4):835-47. DM53079 RU https://pubmed.ncbi.nlm.nih.gov/17300166 DM53079 DI DM53079 DM53079 DN DVDAVP DM53079 MI TTK8R02 DM53079 MN Vasopressin V2 receptor (V2R) DM53079 MT DTT DM53079 MA Inhibitor DM53079 RN Design and synthesis of the first selective agonists for the rat vasopressin V(1b) receptor: based on modifications of deamino-[Cys1]arginine vasop... J Med Chem. 2007 Feb 22;50(4):835-47. DM53079 RU https://pubmed.ncbi.nlm.nih.gov/17300166 DMWF9GQ DI DMWF9GQ DMWF9GQ DN DVD-Ig DMWF9GQ MI TTRYK0X DMWF9GQ MN Interleukin-1 beta (IL1B) DMWF9GQ MT DTT DMWF9GQ MA Modulator DMWF9GQ RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2623). DMWF9GQ RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2623 DMEUVIP DI DMEUVIP DMEUVIP DN DwFwLL-NH2 DMEUVIP MI TTWDC17 DMEUVIP MN Growth hormone secretagogue receptor 1 (GHSR) DMEUVIP MT DTT DMEUVIP MA Inhibitor DMEUVIP RN Identification of an efficacy switch region in the ghrelin receptor responsible for interchange between agonism and inverse agonism. J Biol Chem. 2007 May 25;282(21):15799-811. DMEUVIP RU https://pubmed.ncbi.nlm.nih.gov/17371869 DMW9GT7 DI DMW9GT7 DMW9GT7 DN DwLIP-GCGRrx DMW9GT7 MI TT9O6WS DMW9GT7 MN Glucagon receptor (GCGR) DMW9GT7 MT DTT DMW9GT7 MA Binder DMW9GT7 RN Clinical pipeline report, company report or official report of ISIS Pharmaceuticals (2009). DMW9GT7 RU http://www.isispharm.com/Pipeline/index.htm DMF9M06 DI DMF9M06 DMF9M06 DN DX-2400 DMF9M06 MI TTJ4QE7 DMF9M06 MN Matrix metalloproteinase-14 (MMP-14) DMF9M06 MT DTT DMF9M06 MA Inhibitor DMF9M06 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1638). DMF9M06 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1638 DM3BWTM DI DM3BWTM DM3BWTM DN DX-2500 DM3BWTM MI TTPY4SE DM3BWTM MN Immunoglobulin Fc receptor (FCR) DM3BWTM MT DTT DM3BWTM RN Fully Human Monoclonal Antibody Inhibitors of the Neonatal Fc Receptor Reduce Circulating IgG in Non-Human Primates. Front Immunol. 2015; 6: 176. DM3BWTM RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4407741/ DMZWAQ3 DI DMZWAQ3 DMZWAQ3 DN DXL-625 DMZWAQ3 MI TTUE541 DMZWAQ3 MN Leukocyte surface antigen Leu-16 (CD20) DMZWAQ3 MT DTT DMZWAQ3 MA Modulator DMZWAQ3 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2628). DMZWAQ3 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2628 DM1ROU7 DI DM1ROU7 DM1ROU7 DN D-xylulose DM1ROU7 MI DECFU6W DM1ROU7 MN Xylulose kinase (XYLB) DM1ROU7 MT DME DM1ROU7 MA Metabolism DM1ROU7 RN Structure and function of human xylulokinase, an enzyme with important roles in carbohydrate metabolism. J Biol Chem. 2013 Jan 18;288(3):1643-52. DM1ROU7 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=23179721 DMFJ3VC DI DMFJ3VC DMFJ3VC DN DY131 DMFJ3VC MI TTKF0XS DMFJ3VC MN Estrogen-related receptor-beta (ESRRB) DMFJ3VC MT DTT DMFJ3VC MA Agonist DMFJ3VC RN Identification of an agonist ligand for estrogen-related receptors ERRbeta/gamma. Bioorg Med Chem Lett. 2005 Mar 1;15(5):1311-3. DMFJ3VC RU https://pubmed.ncbi.nlm.nih.gov/15713377 DMFJ3VC DI DMFJ3VC DMFJ3VC DN DY131 DMFJ3VC MI TT9ZRHB DMFJ3VC MN Estrogen-related receptor-gamma (ESRRG) DMFJ3VC MT DTT DMFJ3VC MA Agonist DMFJ3VC RN Identification and structure-activity relationship of phenolic acyl hydrazones as selective agonists for the estrogen-related orphan nuclear receptors ERRbeta and ERRgamma. J Med Chem. 2005 May 5;48(9):3107-9. DMFJ3VC RU https://pubmed.ncbi.nlm.nih.gov/15857113 DMSPVLM DI DMSPVLM DMSPVLM DN dynorphin B DMSPVLM MI TT27RFC DMSPVLM MN Opioid receptor delta (OPRD1) DMSPVLM MT DTT DMSPVLM MA Agonist DMSPVLM RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 317). DMSPVLM RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=317 DMSPVLM DI DMSPVLM DMSPVLM DN dynorphin B DMSPVLM MI TTQW87Y DMSPVLM MN Opioid receptor kappa (OPRK1) DMSPVLM MT DTT DMSPVLM MA Agonist DMSPVLM RN Cloning and functional comparison of kappa and delta opioid receptors from mouse brain. Proc Natl Acad Sci U S A. 1993 Jul 15;90(14):6736-40. DMSPVLM RU https://pubmed.ncbi.nlm.nih.gov/8393575 DMSPVLM DI DMSPVLM DMSPVLM DN dynorphin B DMSPVLM MI TTKWM86 DMSPVLM MN Opioid receptor mu (MOP) DMSPVLM MT DTT DMSPVLM MA Agonist DMSPVLM RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 319). DMSPVLM RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=319 DMM92LG DI DMM92LG DMM92LG DN Dynorphin(1-8) DMM92LG MI TTQW87Y DMM92LG MN Opioid receptor kappa (OPRK1) DMM92LG MT DTT DMM92LG MA Inhibitor DMM92LG RN Peptides as receptor selectivity modulators of opiate pharmacophores. J Med Chem. 1986 Jul;29(7):1222-5. DMM92LG RU https://pubmed.ncbi.nlm.nih.gov/2879914 DMM92LG DI DMM92LG DMM92LG DN Dynorphin(1-8) DMM92LG MI TTKWM86 DMM92LG MN Opioid receptor mu (MOP) DMM92LG MT DTT DMM92LG MA Inhibitor DMM92LG RN Peptides as receptor selectivity modulators of opiate pharmacophores. J Med Chem. 1986 Jul;29(7):1222-5. DMM92LG RU https://pubmed.ncbi.nlm.nih.gov/2879914 DMIZQTX DI DMIZQTX DMIZQTX DN DYSIDENIN DMIZQTX MI TT12ABZ DMIZQTX MN Arachidonate 12-lipoxygenase (12-LOX) DMIZQTX MT DTT DMIZQTX MA Inhibitor DMIZQTX RN Discovery of platelet-type 12-human lipoxygenase selective inhibitors by high-throughput screening of structurally diverse libraries. Bioorg Med Chem. 2007 Nov 15;15(22):6900-8. DMIZQTX RU https://pubmed.ncbi.nlm.nih.gov/17826100 DMIZQTX DI DMIZQTX DMIZQTX DN DYSIDENIN DMIZQTX MI TTN9T81 DMIZQTX MN Arachidonate 15-lipoxygenase (15-LOX) DMIZQTX MT DTT DMIZQTX MA Inhibitor DMIZQTX RN Discovery of platelet-type 12-human lipoxygenase selective inhibitors by high-throughput screening of structurally diverse libraries. Bioorg Med Chem. 2007 Nov 15;15(22):6900-8. DMIZQTX RU https://pubmed.ncbi.nlm.nih.gov/17826100 DMNYQL9 DI DMNYQL9 DMNYQL9 DN DYSIDINE DMNYQL9 MI TTO8QRU DMNYQL9 MN Group IIA phospholipase A2 (GIIA sPLA2) DMNYQL9 MT DTT DMNYQL9 MA Inhibitor DMNYQL9 RN New sesquiterpene derivatives from the sponge Dysidea species with a selective inhibitor profile against human phospholipase A2 and other leukocyte... J Nat Prod. 2001 May;64(5):612-5. DMNYQL9 RU https://pubmed.ncbi.nlm.nih.gov/11374954 DMNYQL9 DI DMNYQL9 DMNYQL9 DN DYSIDINE DMNYQL9 MI TTELIN2 DMNYQL9 MN PTPN1 messenger RNA (PTPN1 mRNA) DMNYQL9 MT DTT DMNYQL9 MA Inhibitor DMNYQL9 RN A novel sesquiterpene quinone from Hainan sponge Dysidea villosa. Bioorg Med Chem Lett. 2009 Jan 15;19(2):390-2. DMNYQL9 RU https://pubmed.ncbi.nlm.nih.gov/19091557 DM0EBAF DI DM0EBAF DM0EBAF DN dysiherbaine DM0EBAF MI TT0MYE2 DM0EBAF MN Glutamate receptor ionotropic kainate 1 (GRIK1) DM0EBAF MT DTT DM0EBAF MA Agonist DM0EBAF RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 450). DM0EBAF RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=450 DM0EBAF DI DM0EBAF DM0EBAF DN dysiherbaine DM0EBAF MI TT0K5RG DM0EBAF MN Glutamate receptor ionotropic kainate 2 (GRIK2) DM0EBAF MT DTT DM0EBAF MA Agonist DM0EBAF RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 451). DM0EBAF RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=451 DM0EBAF DI DM0EBAF DM0EBAF DN dysiherbaine DM0EBAF MI TTNP6O2 DM0EBAF MN Glutamate receptor ionotropic kainate 3 (GluK3) DM0EBAF MT DTT DM0EBAF MA Agonist DM0EBAF RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 452). DM0EBAF RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=452 DM0EBAF DI DM0EBAF DM0EBAF DN dysiherbaine DM0EBAF MI TTQV6BO DM0EBAF MN Glutamate receptor ionotropic kainate 4 (GluK4) DM0EBAF MT DTT DM0EBAF MA Agonist DM0EBAF RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 453). DM0EBAF RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=453 DM0EBAF DI DM0EBAF DM0EBAF DN dysiherbaine DM0EBAF MI TTO6LI7 DM0EBAF MN Glutamate receptor ionotropic kainate 5 (GRIK5) DM0EBAF MT DTT DM0EBAF MA Agonist DM0EBAF RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 454). DM0EBAF RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=454 DMU42C1 DI DMU42C1 DMU42C1 DN DYSINOSIN A DMU42C1 MI TT6L509 DMU42C1 MN Coagulation factor IIa (F2) DMU42C1 MT DTT DMU42C1 MA Inhibitor DMU42C1 RN From natural products to achiral drug prototypes: potent thrombin inhibitors based on P2/P3 dihydropyrid-2-one core motifs. Bioorg Med Chem Lett. 2009 Sep 15;19(18):5429-32. DMU42C1 RU https://pubmed.ncbi.nlm.nih.gov/19674897 DM0JXBK DI DM0JXBK DM0JXBK DN DZNep DM0JXBK MI TTE2KUJ DM0JXBK MN Adenosylhomocysteinase (AHCY) DM0JXBK MT DTT DM0JXBK MA Inhibitor DM0JXBK RN 3-Deazaneplanocin: a new and potent inhibitor of S-adenosylhomocysteine hydrolase and its effects on human promyelocytic leukemia cell line HL-60. Biochem Biophys Res Commun. 1986 Mar 13;135(2):688-94. DM0JXBK RU https://pubmed.ncbi.nlm.nih.gov/3457563 DM76UJY DI DM76UJY DM76UJY DN E[c(RGDyK)]2 DM76UJY MI TTT1R2L DM76UJY MN Integrin alpha-V (ITGAV) DM76UJY MT DTT DM76UJY MA Inhibitor DM76UJY RN Synthesis and biological evaluation of dimeric RGD peptide-paclitaxel conjugate as a model for integrin-targeted drug delivery. J Med Chem. 2005 Feb 24;48(4):1098-106. DM76UJY RU https://pubmed.ncbi.nlm.nih.gov/15715477 DM76UJY DI DM76UJY DM76UJY DN E[c(RGDyK)]2 DM76UJY MI TTJA1ZO DM76UJY MN ITGB3 messenger RNA (ITGB3 mRNA) DM76UJY MT DTT DM76UJY MA Inhibitor DM76UJY RN Synthesis and biological evaluation of dimeric RGD peptide-paclitaxel conjugate as a model for integrin-targeted drug delivery. J Med Chem. 2005 Feb 24;48(4):1098-106. DM76UJY RU https://pubmed.ncbi.nlm.nih.gov/15715477 DMS1LZI DI DMS1LZI DMS1LZI DN E[c(RGDyK)]2-PTX conjugate DMS1LZI MI TTT1R2L DMS1LZI MN Integrin alpha-V (ITGAV) DMS1LZI MT DTT DMS1LZI MA Inhibitor DMS1LZI RN Synthesis and biological evaluation of dimeric RGD peptide-paclitaxel conjugate as a model for integrin-targeted drug delivery. J Med Chem. 2005 Feb 24;48(4):1098-106. DMS1LZI RU https://pubmed.ncbi.nlm.nih.gov/15715477 DMS1LZI DI DMS1LZI DMS1LZI DN E[c(RGDyK)]2-PTX conjugate DMS1LZI MI TTJA1ZO DMS1LZI MN ITGB3 messenger RNA (ITGB3 mRNA) DMS1LZI MT DTT DMS1LZI MA Inhibitor DMS1LZI RN Synthesis and biological evaluation of dimeric RGD peptide-paclitaxel conjugate as a model for integrin-targeted drug delivery. J Med Chem. 2005 Feb 24;48(4):1098-106. DMS1LZI RU https://pubmed.ncbi.nlm.nih.gov/15715477 DMA9CZV DI DMA9CZV DMA9CZV DN E-003 DMA9CZV MI TTU1E82 DMA9CZV MN Apoptosis regulator Bcl-xL (BCL-xL) DMA9CZV MT DTT DMA9CZV MA Modulator DMA9CZV RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2845). DMA9CZV RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2845 DMHPFMV DI DMHPFMV DMHPFMV DN E-1455 DMHPFMV MI TTE0A2F DMHPFMV MN Dopamine D4 receptor (D4R) DMHPFMV MT DTT DMHPFMV MA Modulator DMHPFMV RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 217). DMHPFMV RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=217 DME5JBH DI DME5JBH DME5JBH DN E-3024 DME5JBH MI TTDIGC1 DME5JBH MN Dipeptidyl peptidase 4 (DPP-4) DME5JBH MT DTT DME5JBH MA Modulator DME5JBH RN E3024, 3-but-2-ynyl-5-methyl-2-piperazin-1-yl-3,5-dihydro-4H-imidazo[4,5-d]pyridazin-4-o ne tosylate, is a novel, selective and competitive dipeptidyl peptidase-IV inhibitor.Eur J Pharmacol.2006 Oct 24;548(1-3):181-7. DME5JBH RU https://www.ncbi.nlm.nih.gov/pubmed/16973152 DMGPRT7 DI DMGPRT7 DMGPRT7 DN E339-3D6 DMGPRT7 MI TTJ8E43 DMGPRT7 MN Apelin receptor (APLNR) DMGPRT7 MT DTT DMGPRT7 MA Agonist DMGPRT7 RN Identification and pharmacological properties of E339-3D6, the first nonpeptidic apelin receptor agonist. FASEB J. 2010 May;24(5):1506-17. DMGPRT7 RU https://pubmed.ncbi.nlm.nih.gov/20040517 DMLZU09 DI DMLZU09 DMLZU09 DN E-52862 DMLZU09 MI TTTPE1L DMLZU09 MN HUMAN opioid receptor sigma 1 (OPRS1) DMLZU09 MT DTT DMLZU09 MA Antagonist DMLZU09 RN A SARS-CoV-2 protein interaction map reveals targets for drug repurposing DMLZU09 RU https://www.nature.com/articles/s41586-020-2286-9 DM0O8KR DI DM0O8KR DM0O8KR DN E55888 DM0O8KR MI TTO9X1H DM0O8KR MN 5-HT 7 receptor (HTR7) DM0O8KR MT DTT DM0O8KR MA Agonist DM0O8KR RN 5-HT7 receptor activation inhibits mechanical hypersensitivity secondary to capsaicin sensitization in mice. Pain. 2009 Feb;141(3):239-47. DM0O8KR RU https://pubmed.ncbi.nlm.nih.gov/19118950 DM8LPBF DI DM8LPBF DM8LPBF DN E5700 DM8LPBF MI TTFQEO5 DM8LPBF MN Squalene synthetase (FDFT1) DM8LPBF MT DTT DM8LPBF MA Inhibitor DM8LPBF RN Kinetic characterization of squalene synthase from Trypanosoma cruzi: selective inhibition by quinuclidine derivatives. Antimicrob Agents Chemother. 2007 Jun;51(6):2123-9. DM8LPBF RU https://pubmed.ncbi.nlm.nih.gov/17371809 DMMOPAK DI DMMOPAK DMMOPAK DN E-64 DMMOPAK MI TTUMQVO DMMOPAK MN Cathepsin S (CTSS) DMMOPAK MT DTT DMMOPAK MA Inhibitor DMMOPAK RN Baculoviral expression and characterization of rodent cathepsin S. Protein Expr Purif. 2001 Oct;23(1):45-54. DMMOPAK RU https://pubmed.ncbi.nlm.nih.gov/11570845 DMMOPAK DI DMMOPAK DMMOPAK DN E-64 DMMOPAK MI TTH9VL3 DMMOPAK MN Plasmodium Plasmepsin 1 (Malaria PLA1) DMMOPAK MT DTT DMMOPAK MA Inhibitor DMMOPAK RN Antimalarial synergy of cysteine and aspartic protease inhibitors. Antimicrob Agents Chemother. 1998 Sep;42(9):2254-8. DMMOPAK RU https://pubmed.ncbi.nlm.nih.gov/9736544 DMMOPAK DI DMMOPAK DMMOPAK DN E-64 DMMOPAK MI TTXMNHO DMMOPAK MN Plasmodium Plasmepsin 2 (Malaria PLA2) DMMOPAK MT DTT DMMOPAK MA Inhibitor DMMOPAK RN Antimalarial synergy of cysteine and aspartic protease inhibitors. Antimicrob Agents Chemother. 1998 Sep;42(9):2254-8. DMMOPAK RU https://pubmed.ncbi.nlm.nih.gov/9736544 DMMOPAK DI DMMOPAK DMMOPAK DN E-64 DMMOPAK MI TTREV7X DMMOPAK MN Virus Cysteine proteinase (Viru VCATH) DMMOPAK MT DTT DMMOPAK MA Inhibitor DMMOPAK RN Characterization of a cysteine proteinase from Taenia crassiceps cysts. Mol Biochem Parasitol. 1997 Apr;85(2):243-53. DMMOPAK RU https://pubmed.ncbi.nlm.nih.gov/9106197 DM7LGAF DI DM7LGAF DM7LGAF DN E6801 DM7LGAF MI TTJS8PY DM7LGAF MN 5-HT 6 receptor (HTR6) DM7LGAF MT DTT DM7LGAF MA Agonist DM7LGAF RN Medicinal chemistry driven approaches toward novel and selective serotonin 5-HT6 receptor ligands. J Med Chem. 2005 Mar 24;48(6):1781-95. DM7LGAF RU https://pubmed.ncbi.nlm.nih.gov/15771424 DMJ2P0N DI DMJ2P0N DMJ2P0N DN E-6837 DMJ2P0N MI TTJS8PY DMJ2P0N MN 5-HT 6 receptor (HTR6) DMJ2P0N MT DTT DMJ2P0N MA Inhibitor DMJ2P0N RN Indene-based scaffolds. 2. An indole-indene switch: discovery of novel indenylsulfonamides as 5-HT6 serotonin receptor agonists. J Med Chem. 2009 Feb 12;52(3):675-87. DMJ2P0N RU https://pubmed.ncbi.nlm.nih.gov/19159187 DM7ROJI DI DM7ROJI DM7ROJI DN E-6-O-p-methoxycinnamoyl scandoside methyl ester DM7ROJI MI TTPLTSQ DM7ROJI MN Neutrophil elastase (NE) DM7ROJI MT DTT DM7ROJI MA Inhibitor DM7ROJI RN Evaluation of human neutrophil elastase inhibitory effect of iridoid glycosides from Hedyotis diffusa. Bioorg Med Chem Lett. 2010 Jan 15;20(2):513-5. DM7ROJI RU https://pubmed.ncbi.nlm.nih.gov/20004577 DMY6DM5 DI DMY6DM5 DMY6DM5 DN E-758 DMY6DM5 MI TTGTQHC DMY6DM5 MN DNA topoisomerase I (TOP1) DMY6DM5 MT DTT DMY6DM5 MA Inhibitor DMY6DM5 RN Lycobetaine acts as a selective topoisomerase IIbeta poison and inhibits the growth of human tumour cells. Br J Cancer. 2001 November; 85(10): 1585-1591. DMY6DM5 RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2363954/ DMB7685 DI DMB7685 DMB7685 DN EAPB0203 DMB7685 MI TTU1E82 DMB7685 MN Apoptosis regulator Bcl-xL (BCL-xL) DMB7685 MT DTT DMB7685 MA Inhibitor DMB7685 RN EAPB0203, a member of the imidazoquinoxaline family, inhibits growth and induces caspase-dependent apoptosis in T-cell lymphomas and HTLV-I-associated adult T-cell leukemia/lymphoma. Blood. 2008 Apr 1;111(7):3770-7. DMB7685 RU https://pubmed.ncbi.nlm.nih.gov/18218850 DMB7685 DI DMB7685 DMB7685 DN EAPB0203 DMB7685 MI TTQ5LRD DMB7685 MN Cellular inhibitor of apoptosis 1 (BIRC2) DMB7685 MT DTT DMB7685 MA Inhibitor DMB7685 RN EAPB0203, a member of the imidazoquinoxaline family, inhibits growth and induces caspase-dependent apoptosis in T-cell lymphomas and HTLV-I-associated adult T-cell leukemia/lymphoma. Blood. 2008 Apr 1;111(7):3770-7. DMB7685 RU https://pubmed.ncbi.nlm.nih.gov/18218850 DM4UZ6V DI DM4UZ6V DM4UZ6V DN EB-47 DM4UZ6V MI TTVDSZ0 DM4UZ6V MN Poly [ADP-ribose] polymerase 1 (PARP1) DM4UZ6V MT DTT DM4UZ6V MA Inhibitor DM4UZ6V RN Poly(ADP-ribose) polymerase and the therapeutic effects of its inhibitors. Nat Rev Drug Discov. 2005 May;4(5):421-40. DM4UZ6V RU https://pubmed.ncbi.nlm.nih.gov/15864271 DMPKI0N DI DMPKI0N DMPKI0N DN EBIO DMPKI0N MI TT9R6BE DMPKI0N MN Calcium-activated potassium channel KCa2.1 (KCNN1) DMPKI0N MT DTT DMPKI0N MA Activator DMPKI0N RN Small conductance calcium-activated potassium channels: from structure to function. Prog Neurobiol. 2010 Jul;91(3):242-55. DMPKI0N RU https://pubmed.ncbi.nlm.nih.gov/20359520 DMPKI0N DI DMPKI0N DMPKI0N DN EBIO DMPKI0N MI TT2T5M0 DMPKI0N MN Calcium-activated potassium channel KCa2.2 (KCNN2) DMPKI0N MT DTT DMPKI0N MA Activator DMPKI0N RN Small conductance calcium-activated potassium channels: from structure to function. Prog Neurobiol. 2010 Jul;91(3):242-55. DMPKI0N RU https://pubmed.ncbi.nlm.nih.gov/20359520 DMPKI0N DI DMPKI0N DMPKI0N DN EBIO DMPKI0N MI TT9JH25 DMPKI0N MN Calcium-activated potassium channel KCa2.3 (KCNN3) DMPKI0N MT DTT DMPKI0N MA Activator DMPKI0N RN Small conductance calcium-activated potassium channels: from structure to function. Prog Neurobiol. 2010 Jul;91(3):242-55. DMPKI0N RU https://pubmed.ncbi.nlm.nih.gov/20359520 DMPKI0N DI DMPKI0N DMPKI0N DN EBIO DMPKI0N MI TT7M9I6 DMPKI0N MN Calcium-activated potassium channel KCa3.1 (KCNN4) DMPKI0N MT DTT DMPKI0N MA Activator DMPKI0N RN Small conductance calcium-activated potassium channels: from structure to function. Prog Neurobiol. 2010 Jul;91(3):242-55. DMPKI0N RU https://pubmed.ncbi.nlm.nih.gov/20359520 DMIC372 DI DMIC372 DMIC372 DN EC-0565 DMIC372 MI TTCJG29 DMIC372 MN Serine/threonine-protein kinase mTOR (mTOR) DMIC372 MT DTT DMIC372 MA Inhibitor DMIC372 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2109). DMIC372 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2109 DMK6E10 DI DMK6E10 DMK6E10 DN EC-0845 DMK6E10 MI TTCJG29 DMK6E10 MN Serine/threonine-protein kinase mTOR (mTOR) DMK6E10 MT DTT DMK6E10 MA Modulator DMK6E10 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2109). DMK6E10 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2109 DM61FB0 DI DM61FB0 DM61FB0 DN EC18 DM61FB0 MI TTQP04A DM61FB0 MN Hyperpolarization cyclic nucleotide-gated channel 4 (HCN4) DM61FB0 MT DTT DM61FB0 MA Blocker (channel blocker) DM61FB0 RN Novel blockers of hyperpolarization-activated current with isoform selectivity in recombinant cells and native tissue. Br J Pharmacol. 2012 May;166(2):602-16. DM61FB0 RU https://pubmed.ncbi.nlm.nih.gov/22091830 DM67549 DI DM67549 DM67549 DN EC33 DM67549 MI TT9PBIL DM67549 MN Glutamyl aminopeptidase (ENPEP) DM67549 MT DTT DM67549 MA Inhibitor DM67549 RN Aminopeptidase A, which generates one of the main effector peptides of the brain renin-angiotensin system, angiotensin III, has a key role in central control of arterial blood pressure. Biochem Soc Trans. 2000;28(4):435-40. DM67549 RU https://pubmed.ncbi.nlm.nih.gov/10961935 DMIVY0Q DI DMIVY0Q DMIVY0Q DN Eckol DMIVY0Q MI TT8JRS7 DMIVY0Q MN Beta-secretase (BACE) DMIVY0Q MT DTT DMIVY0Q MA Inhibitor DMIVY0Q RN Molecular docking studies of phlorotannins from Eisenia bicyclis with BACE1 inhibitory activity. Bioorg Med Chem Lett. 2010 Jun 1;20(11):3211-5. DMIVY0Q RU https://pubmed.ncbi.nlm.nih.gov/20462757 DMWKS29 DI DMWKS29 DMWKS29 DN ECOPLADIB DMWKS29 MI TTT1JVS DMWKS29 MN Cytosolic phospholipase A2 (GIVA cPLA2) DMWKS29 MT DTT DMWKS29 MA Inhibitor DMWKS29 RN Reactions of functionalized sulfonamides: application to lowering the lipophilicity of cytosolic phospholipase A2alpha inhibitors. J Med Chem. 2009 Feb 26;52(4):1156-71. DMWKS29 RU https://pubmed.ncbi.nlm.nih.gov/19178292 DMYZVLN DI DMYZVLN DMYZVLN DN EC-SOD DMYZVLN MI TT6RVLG DMYZVLN MN Superoxide dismutase Cu-Zn (SOD Cu-Zn) DMYZVLN MT DTT DMYZVLN MA Modulator DMYZVLN RN Extracellular superoxide dismutase (ecSOD) in vascular biology: an update on exogenous gene transfer and endogenous regulators of ecSOD.Transl Res.2008 Feb;151(2):68-78. DMYZVLN RU https://www.ncbi.nlm.nih.gov/pubmed/18201674 DM5QS17 DI DM5QS17 DM5QS17 DN ED1 DM5QS17 MI TTPLTSQ DM5QS17 MN Neutrophil elastase (NE) DM5QS17 MT DTT DM5QS17 RN Therapeutic applications of aptamers. Expert Opin Investig Drugs. 2008 Jan;17(1):43-60. DM5QS17 RU https://pubmed.ncbi.nlm.nih.gov/18095918 DMX32JY DI DMX32JY DMX32JY DN ED45 DMX32JY MI TTPLTSQ DMX32JY MN Neutrophil elastase (NE) DMX32JY MT DTT DMX32JY RN Therapeutic applications of aptamers. Expert Opin Investig Drugs. 2008 Jan;17(1):43-60. DMX32JY RU https://pubmed.ncbi.nlm.nih.gov/18095918 DM32O0L DI DM32O0L DM32O0L DN Edatrexate DM32O0L MI TT9SL3Q DM32O0L MN Polypeptide deformylase (PDF) DM32O0L MT DTT DM32O0L MA Inhibitor DM32O0L RN Loss of folylpoly-gamma-glutamate synthetase activity is a dominant mechanism of resistance to polyglutamylation-dependent novel antifolates in multiple human leukemia sublines. Int J Cancer. 2003 Feb 20;103(5):587-99. DM32O0L RU https://pubmed.ncbi.nlm.nih.gov/12494465 DM10D85 DI DM10D85 DM10D85 DN Edetic acid DM10D85 MI TT0VH8G DM10D85 MN Elegans Endoprotease bli-4 (Elegans bli-4) DM10D85 MT DTT DM10D85 MA Inhibitor DM10D85 RN Removal of the glycosylphosphatidylinositol anchor from PrP(Sc) by cathepsin D does not reduce prion infectivity. Biochem J. 2006 Apr 15;395(2):443-8. DM10D85 RU https://pubmed.ncbi.nlm.nih.gov/16441239 DMS3AXK DI DMS3AXK DMS3AXK DN EDMT DMS3AXK MI TTSQIFT DMS3AXK MN 5-HT 1A receptor (HTR1A) DMS3AXK MT DTT DMS3AXK MA Agonist DMS3AXK RN 2-Substituted tryptamines: agents with selectivity for 5-HT(6) serotonin receptors. J Med Chem. 2000 Mar 9;43(5):1011-8. DMS3AXK RU https://pubmed.ncbi.nlm.nih.gov/10715164 DMS3AXK DI DMS3AXK DMS3AXK DN EDMT DMS3AXK MI TT6MSOK DMS3AXK MN 5-HT 1D receptor (HTR1D) DMS3AXK MT DTT DMS3AXK MA Agonist DMS3AXK RN 2-Substituted tryptamines: agents with selectivity for 5-HT(6) serotonin receptors. J Med Chem. 2000 Mar 9;43(5):1011-8. DMS3AXK RU https://pubmed.ncbi.nlm.nih.gov/10715164 DMS3AXK DI DMS3AXK DMS3AXK DN EDMT DMS3AXK MI TTCPG9S DMS3AXK MN 5-HT 1E receptor (HTR1E) DMS3AXK MT DTT DMS3AXK MA Agonist DMS3AXK RN 2-Substituted tryptamines: agents with selectivity for 5-HT(6) serotonin receptors. J Med Chem. 2000 Mar 9;43(5):1011-8. DMS3AXK RU https://pubmed.ncbi.nlm.nih.gov/10715164 DMS3AXK DI DMS3AXK DMS3AXK DN EDMT DMS3AXK MI TTRUFDT DMS3AXK MN 5-HT 5A receptor (HTR5A) DMS3AXK MT DTT DMS3AXK MA Agonist DMS3AXK RN 2-Substituted tryptamines: agents with selectivity for 5-HT(6) serotonin receptors. J Med Chem. 2000 Mar 9;43(5):1011-8. DMS3AXK RU https://pubmed.ncbi.nlm.nih.gov/10715164 DMS3AXK DI DMS3AXK DMS3AXK DN EDMT DMS3AXK MI TTJS8PY DMS3AXK MN 5-HT 6 receptor (HTR6) DMS3AXK MT DTT DMS3AXK MA Inhibitor DMS3AXK RN 2-Substituted tryptamines: agents with selectivity for 5-HT(6) serotonin receptors. J Med Chem. 2000 Mar 9;43(5):1011-8. DMS3AXK RU https://pubmed.ncbi.nlm.nih.gov/10715164 DMS3AXK DI DMS3AXK DMS3AXK DN EDMT DMS3AXK MI TTO9X1H DMS3AXK MN 5-HT 7 receptor (HTR7) DMS3AXK MT DTT DMS3AXK MA Agonist DMS3AXK RN 2-Substituted tryptamines: agents with selectivity for 5-HT(6) serotonin receptors. J Med Chem. 2000 Mar 9;43(5):1011-8. DMS3AXK RU https://pubmed.ncbi.nlm.nih.gov/10715164 DMHCGIS DI DMHCGIS DMHCGIS DN EDN-OL1 DMHCGIS MI TTE4KHA DMHCGIS MN Amyloid beta A4 protein (APP) DMHCGIS MT DTT DMHCGIS MA Modulator DMHCGIS RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2402). DMHCGIS RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2402 DMC7DYX DI DMC7DYX DMC7DYX DN Edoxudine DMC7DYX MI TTP3QRF DMC7DYX MN Thymidine kinase 1 (TK1) DMC7DYX MT DTT DMC7DYX MA Inhibitor DMC7DYX RN Sensitivity of monkey B virus (Cercopithecine herpesvirus 1) to antiviral drugs: role of thymidine kinase in antiviral activities of substrate anal... Antimicrob Agents Chemother. 2007 Jun;51(6):2028-34. DMC7DYX RU https://pubmed.ncbi.nlm.nih.gov/17438061 DMLSMBI DI DMLSMBI DMLSMBI DN EDP-13 DMLSMBI MI TTGKNB4 DMLSMBI MN Epidermal growth factor receptor (EGFR) DMLSMBI MT DTT DMLSMBI MA Antagonist DMLSMBI RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1797). DMLSMBI RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1797 DMTVRKG DI DMTVRKG DMTVRKG DN EDP-18 DMTVRKG MI TT946IA DMTVRKG MN Transient receptor potential cation channel V3 (TRPV3) DMTVRKG MT DTT DMTVRKG MA Agonist DMTVRKG RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 509). DMTVRKG RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=509 DMMN0GO DI DMMN0GO DMMN0GO DN EDP-21 DMMN0GO MI TT0HD6V DMMN0GO MN Leptin receptor (LEPR) DMMN0GO MT DTT DMMN0GO MA Agonist DMMN0GO RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1712). DMMN0GO RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1712 DMN8JKX DI DMN8JKX DMN8JKX DN E-EBU-dM DMN8JKX MI TT84ETX DMN8JKX MN Human immunodeficiency virus Reverse transcriptase (HIV RT) DMN8JKX MT DTT DMN8JKX MA Modulator DMN8JKX RN Construction of the chimeric reverse transcriptase of simian immunodeficiency virus sensitive to nonnucleoside reverse transcriptase inhibitor. Microbiol Immunol. 1998;42(3):195-202. DMN8JKX RU https://www.ncbi.nlm.nih.gov/pubmed/9570285 DMXZRND DI DMXZRND DMXZRND DN EFFUSOL DMXZRND MI TTZAYWL DMXZRND MN Estrogen receptor (ESR) DMXZRND MT DTT DMXZRND MA Inhibitor DMXZRND RN 6H-Benzo[c]chromen-6-one derivatives as selective ERbeta agonists. Bioorg Med Chem Lett. 2006 Mar 15;16(6):1468-72. DMXZRND RU https://pubmed.ncbi.nlm.nih.gov/16412638 DMXZRND DI DMXZRND DMXZRND DN EFFUSOL DMXZRND MI TTOM3J0 DMXZRND MN Estrogen receptor beta (ESR2) DMXZRND MT DTT DMXZRND MA Inhibitor DMXZRND RN 6H-Benzo[c]chromen-6-one derivatives as selective ERbeta agonists. Bioorg Med Chem Lett. 2006 Mar 15;16(6):1468-72. DMXZRND RU https://pubmed.ncbi.nlm.nih.gov/16412638 DMOKX76 DI DMOKX76 DMOKX76 DN Efomycine M DMOKX76 MI TTAU4D6 DMOKX76 MN E-selectin (SELE) DMOKX76 MT DTT DMOKX76 MA Inhibitor DMOKX76 RN Interfering with leukocyte rolling--a promising therapeutic approach in inflammatory skin disorders Trends Pharmacol Sci. 2003 Feb;24(2):49-52. DMOKX76 RU https://pubmed.ncbi.nlm.nih.gov/12559762 DMOKX76 DI DMOKX76 DMOKX76 DN Efomycine M DMOKX76 MI TTE5VG0 DMOKX76 MN P-selectin (SELP) DMOKX76 MT DTT DMOKX76 MA Inhibitor DMOKX76 RN Interfering with leukocyte rolling--a promising therapeutic approach in inflammatory skin disorders Trends Pharmacol Sci. 2003 Feb;24(2):49-52. DMOKX76 RU https://pubmed.ncbi.nlm.nih.gov/12559762 DMZ2XOH DI DMZ2XOH DMZ2XOH DN EFPPEA DMZ2XOH MI TT0WAIE DMZ2XOH MN Melatonin receptor type 1A (MTNR1A) DMZ2XOH MT DTT DMZ2XOH MA Agonist DMZ2XOH RN Synthesis of a novel series of tricyclic dihydrofuran derivatives: discovery of 8,9-dihydrofuro[3,2-c]pyrazolo[1,5-a]pyridines as melatonin receptor (MT1/MT2) ligands. J Med Chem. 2011 Jun 23;54(12):4207-18. DMZ2XOH RU https://pubmed.ncbi.nlm.nih.gov/21568291 DMRP9K3 DI DMRP9K3 DMRP9K3 DN EG-10 DMRP9K3 MI TTJTRMK DMRP9K3 MN Interleukin 10 receptor (IL10RB) DMRP9K3 MT DTT DMRP9K3 MA Modulator DMRP9K3 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1900). DMRP9K3 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1900 DM7AYH4 DI DM7AYH4 DM7AYH4 DN EGFR inhibitor DM7AYH4 MI TTGKNB4 DM7AYH4 MN Epidermal growth factor receptor (EGFR) DM7AYH4 MT DTT DM7AYH4 MA Inhibitor DM7AYH4 RN A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases. Proc Natl Acad Sci U S A. 2007 Dec 18;104(51):20523-8. DM7AYH4 RU https://pubmed.ncbi.nlm.nih.gov/18077363 DMLK4X5 DI DMLK4X5 DMLK4X5 DN EGIS-7625 DMLK4X5 MI TTJQOD7 DMLK4X5 MN 5-HT 2A receptor (HTR2A) DMLK4X5 MT DTT DMLK4X5 MA Antagonist DMLK4X5 RN Effects of EGIS-7625, a selective and competitive 5-HT2B receptor antagonist. Cardiovasc Drugs Ther. 2003 Sep-Nov;17(5-6):427-34. DMLK4X5 RU https://pubmed.ncbi.nlm.nih.gov/15107597 DMLK4X5 DI DMLK4X5 DMLK4X5 DN EGIS-7625 DMLK4X5 MI TT0K1SC DMLK4X5 MN 5-HT 2B receptor (HTR2B) DMLK4X5 MT DTT DMLK4X5 MA Antagonist DMLK4X5 RN Effects of EGIS-7625, a selective and competitive 5-HT2B receptor antagonist. Cardiovasc Drugs Ther. 2003 Sep-Nov;17(5-6):427-34. DMLK4X5 RU https://pubmed.ncbi.nlm.nih.gov/15107597 DMLK4X5 DI DMLK4X5 DMLK4X5 DN EGIS-7625 DMLK4X5 MI TTWJBZ5 DMLK4X5 MN 5-HT 2C receptor (HTR2C) DMLK4X5 MT DTT DMLK4X5 MA Antagonist DMLK4X5 RN Effects of EGIS-7625, a selective and competitive 5-HT2B receptor antagonist. Cardiovasc Drugs Ther. 2003 Sep-Nov;17(5-6):427-34. DMLK4X5 RU https://pubmed.ncbi.nlm.nih.gov/15107597 DMKW0Q3 DI DMKW0Q3 DMKW0Q3 DN eGlu DMKW0Q3 MI TTXJ47W DMKW0Q3 MN Metabotropic glutamate receptor 2 (mGluR2) DMKW0Q3 MT DTT DMKW0Q3 MA Antagonist DMKW0Q3 RN Characterization of [(3)H]-LY354740 binding to rat mGlu2 and mGlu3 receptors expressed in CHO cells using semliki forest virus vectors. Neuropharmacology. 2000 Jul 24;39(10):1700-6. DMKW0Q3 RU https://pubmed.ncbi.nlm.nih.gov/10884552 DMKW0Q3 DI DMKW0Q3 DMKW0Q3 DN eGlu DMKW0Q3 MI TT8A9EF DMKW0Q3 MN Metabotropic glutamate receptor 3 (mGluR3) DMKW0Q3 MT DTT DMKW0Q3 MA Antagonist DMKW0Q3 RN Characterization of [(3)H]-LY354740 binding to rat mGlu2 and mGlu3 receptors expressed in CHO cells using semliki forest virus vectors. Neuropharmacology. 2000 Jul 24;39(10):1700-6. DMKW0Q3 RU https://pubmed.ncbi.nlm.nih.gov/10884552 DMW9MRO DI DMW9MRO DMW9MRO DN EGTA DMW9MRO MI TTBLN9S DMW9MRO MN Sulfur mustard-stimulated protease (SMSP) DMW9MRO MT DTT DMW9MRO MA Inhibitor DMW9MRO RN Sulfur mustard-stimulated protease: a target for antivesicant drugs. J Appl Toxicol. 2002 Mar-Apr;22(2):139-40. DMW9MRO RU https://pubmed.ncbi.nlm.nih.gov/11920939 DM014WS DI DM014WS DM014WS DN EHNA DM014WS MI TTLP57V DM014WS MN Adenosine deaminase (ADA) DM014WS MT DTT DM014WS MA Inhibitor DM014WS RN Tight-binding inhibitors--IV. Inhibition of adenosine deaminases by various inhibitors. Biochem Pharmacol. 1977 Mar 1;26(5):359-67. DM014WS RU https://pubmed.ncbi.nlm.nih.gov/849330 DM014WS DI DM014WS DM014WS DN EHNA DM014WS MI TTJGW1Z DM014WS MN Phosphodiesterase 2A (PDE2A) DM014WS MT DTT DM014WS MA Inhibitor DM014WS RN Rapid regulation of PDE-2 and PDE-4 cyclic AMP phosphodiesterase activity following ligation of the T cell antigen receptor on thymocytes: analysis using the selective inhibitors erythro-9-(2-hydroxy-3-nonyl)-adenine (EHNA) and rolipram. Cell Signal. 1996 Feb;8(2):97-110. DM014WS RU https://pubmed.ncbi.nlm.nih.gov/8730511 DMBQCMU DI DMBQCMU DMBQCMU DN EI1 DMBQCMU MI TT9MZCQ DMBQCMU MN Enhancer of zeste homolog 2 (EZH2) DMBQCMU MT DTT DMBQCMU MA Inhibitor DMBQCMU RN Selective inhibition of Ezh2 by a small molecule inhibitor blocks tumor cells proliferation. Proc Natl Acad Sci U S A. 2012 Dec 26;109(52):21360-5. DMBQCMU RU https://pubmed.ncbi.nlm.nih.gov/23236167 DMVJK9W DI DMVJK9W DMVJK9W DN Eicosadienoic acid DMVJK9W MI DE073H6 DMVJK9W MN Prostaglandin G/H synthase 1 (COX-1) DMVJK9W MT DME DMVJK9W MA Metabolism DMVJK9W RN Divergent cyclooxygenase responses to fatty acid structure and peroxide level in fish and mammalian prostaglandin H synthases. FASEB J. 2006 Jun;20(8):1097-108. DMVJK9W RU https://www.ncbi.nlm.nih.gov/pubmed/?term=16770009 DMVJK9W DI DMVJK9W DMVJK9W DN Eicosadienoic acid DMVJK9W MI DE492CE DMVJK9W MN Prostaglandin G/H synthase 2 (COX-2) DMVJK9W MT DME DMVJK9W MA Metabolism DMVJK9W RN Divergent cyclooxygenase responses to fatty acid structure and peroxide level in fish and mammalian prostaglandin H synthases. FASEB J. 2006 Jun;20(8):1097-108. DMVJK9W RU https://www.ncbi.nlm.nih.gov/pubmed/?term=16770009 DMAKP20 DI DMAKP20 DMAKP20 DN eicosatetranoic acid DMAKP20 MI TTJ584C DMAKP20 MN Peroxisome proliferator-activated receptor alpha (PPARA) DMAKP20 MT DTT DMAKP20 MA Agonist DMAKP20 RN PPAR alpha structure-function relationships derived from species-specific differences in responsiveness to hypolipidemic agents. Biol Chem. 1997 Jul;378(7):651-5. DMAKP20 RU https://pubmed.ncbi.nlm.nih.gov/9278144 DM03X7D DI DM03X7D DM03X7D DN EISAI-1 DM03X7D MI TTTUMEP DM03X7D MN Neurotensin receptor type 1 (NTSR1) DM03X7D MT DTT DM03X7D MA Agonist DM03X7D RN Differential involvement of intracellular domains of the rat NTS1 neurotensin receptor in coupling to G proteins: a molecular basis for agonist-directed trafficking of receptor stimulus. Mol Pharmacol. 2003 Aug;64(2):421-9. DM03X7D RU https://pubmed.ncbi.nlm.nih.gov/12869647 DMRHSCQ DI DMRHSCQ DMRHSCQ DN ELAEOCARPENINE DMRHSCQ MI TT27RFC DMRHSCQ MN Opioid receptor delta (OPRD1) DMRHSCQ MT DTT DMRHSCQ MA Inhibitor DMRHSCQ RN Synthesis and evaluation of opioid receptor-binding affinity of elaeocarpenine and its analogs. Bioorg Med Chem Lett. 2010 Mar 1;20(5):1601-3. DMRHSCQ RU https://pubmed.ncbi.nlm.nih.gov/20144865 DMRHSCQ DI DMRHSCQ DMRHSCQ DN ELAEOCARPENINE DMRHSCQ MI TTQW87Y DMRHSCQ MN Opioid receptor kappa (OPRK1) DMRHSCQ MT DTT DMRHSCQ MA Inhibitor DMRHSCQ RN Synthesis and evaluation of opioid receptor-binding affinity of elaeocarpenine and its analogs. Bioorg Med Chem Lett. 2010 Mar 1;20(5):1601-3. DMRHSCQ RU https://pubmed.ncbi.nlm.nih.gov/20144865 DMRHSCQ DI DMRHSCQ DMRHSCQ DN ELAEOCARPENINE DMRHSCQ MI TTKWM86 DMRHSCQ MN Opioid receptor mu (MOP) DMRHSCQ MT DTT DMRHSCQ MA Inhibitor DMRHSCQ RN Synthesis and evaluation of opioid receptor-binding affinity of elaeocarpenine and its analogs. Bioorg Med Chem Lett. 2010 Mar 1;20(5):1601-3. DMRHSCQ RU https://pubmed.ncbi.nlm.nih.gov/20144865 DMP8VDT DI DMP8VDT DMP8VDT DN Elaidoylamide DMP8VDT MI TTO9X1H DMP8VDT MN 5-HT 7 receptor (HTR7) DMP8VDT MT DTT DMP8VDT MA Modulator (allosteric modulator) DMP8VDT RN Allosteric regulation by oleamide of the binding properties of 5-hydroxytryptamine7 receptors. Biochem Pharmacol. 1999 Dec 1;58(11):1807-13. DMP8VDT RU https://pubmed.ncbi.nlm.nih.gov/10571256 DMP8VDT DI DMP8VDT DMP8VDT DN Elaidoylamide DMP8VDT MI TTO8QRU DMP8VDT MN Group IIA phospholipase A2 (GIIA sPLA2) DMP8VDT MT DTT DMP8VDT MA Inhibitor DMP8VDT RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMP8VDT RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMEOJ9W DI DMEOJ9W DMEOJ9W DN eledoisin DMEOJ9W MI TTBPGLU DMEOJ9W MN Neuromedin-K receptor (TACR3) DMEOJ9W MT DTT DMEOJ9W MA Agonist DMEOJ9W RN Molecular characterisation, expression and localisation of human neurokinin-3 receptor. FEBS Lett. 1992 Mar 24;299(1):90-5. DMEOJ9W RU https://pubmed.ncbi.nlm.nih.gov/1312036 DMEOJ9W DI DMEOJ9W DMEOJ9W DN eledoisin DMEOJ9W MI TTZPO1L DMEOJ9W MN Substance-P receptor (TACR1) DMEOJ9W MT DTT DMEOJ9W MA Agonist DMEOJ9W RN The unpredicted high affinities of a large number of naturally occurring tachykinins for chimeric NK1/NK3 receptors suggest a role for an inhibitory domain in determining receptor specificity. J BiolChem. 1996 Aug 23;271(34):20250-7. DMEOJ9W RU https://pubmed.ncbi.nlm.nih.gov/8702757 DMMVZU0 DI DMMVZU0 DMMVZU0 DN Eleutherobin DMMVZU0 MI TTML2WA DMMVZU0 MN Tubulin (TUB) DMMVZU0 MT DTT DMMVZU0 MA Inducer DMMVZU0 RN Eleutherobin, a novel cytotoxic agent that induces tubulin polymerization, is similar to paclitaxel (Taxol). Cancer Res. 1998 Mar 15;58(6):1111-5. DMMVZU0 RU https://pubmed.ncbi.nlm.nih.gov/9515790 DMX8BS5 DI DMX8BS5 DMX8BS5 DN ELLAGIC ACID DMX8BS5 MI TTUNARX DMX8BS5 MN Carbonic anhydrase (CA) DMX8BS5 MT DTT DMX8BS5 MA Inhibitor DMX8BS5 RN Carbonic anhydrase inhibitors. Inhibition of mammalian isoforms I-XIV with a series of natural product polyphenols and phenolic acids. Bioorg Med Chem. 2010 Mar 15;18(6):2159-2164. DMX8BS5 RU https://pubmed.ncbi.nlm.nih.gov/20185318 DMX8BS5 DI DMX8BS5 DMX8BS5 DN ELLAGIC ACID DMX8BS5 MI TTHQPL7 DMX8BS5 MN Carbonic anhydrase I (CA-I) DMX8BS5 MT DTT DMX8BS5 MA Inhibitor DMX8BS5 RN Carbonic anhydrase inhibitors. Inhibition of mammalian isoforms I-XIV with a series of natural product polyphenols and phenolic acids. Bioorg Med Chem. 2010 Mar 15;18(6):2159-2164. DMX8BS5 RU https://pubmed.ncbi.nlm.nih.gov/20185318 DMX8BS5 DI DMX8BS5 DMX8BS5 DN ELLAGIC ACID DMX8BS5 MI TTANPDJ DMX8BS5 MN Carbonic anhydrase II (CA-II) DMX8BS5 MT DTT DMX8BS5 MA Inhibitor DMX8BS5 RN Carbonic anhydrase inhibitors. Inhibition of mammalian isoforms I-XIV with a series of natural product polyphenols and phenolic acids. Bioorg Med Chem. 2010 Mar 15;18(6):2159-2164. DMX8BS5 RU https://pubmed.ncbi.nlm.nih.gov/20185318 DMX8BS5 DI DMX8BS5 DMX8BS5 DN ELLAGIC ACID DMX8BS5 MI TTZHA0O DMX8BS5 MN Carbonic anhydrase IV (CA-IV) DMX8BS5 MT DTT DMX8BS5 MA Inhibitor DMX8BS5 RN Carbonic anhydrase inhibitors. Inhibition of mammalian isoforms I-XIV with a series of natural product polyphenols and phenolic acids. Bioorg Med Chem. 2010 Mar 15;18(6):2159-2164. DMX8BS5 RU https://pubmed.ncbi.nlm.nih.gov/20185318 DMX8BS5 DI DMX8BS5 DMX8BS5 DN ELLAGIC ACID DMX8BS5 MI TT2LVK8 DMX8BS5 MN Carbonic anhydrase IX (CA-IX) DMX8BS5 MT DTT DMX8BS5 MA Inhibitor DMX8BS5 RN Carbonic anhydrase inhibitors. Inhibition of mammalian isoforms I-XIV with a series of natural product polyphenols and phenolic acids. Bioorg Med Chem. 2010 Mar 15;18(6):2159-2164. DMX8BS5 RU https://pubmed.ncbi.nlm.nih.gov/20185318 DMX8BS5 DI DMX8BS5 DMX8BS5 DN ELLAGIC ACID DMX8BS5 MI TTCFSPE DMX8BS5 MN Carbonic anhydrase VI (CA-VI) DMX8BS5 MT DTT DMX8BS5 MA Inhibitor DMX8BS5 RN Carbonic anhydrase inhibitors. Inhibition of mammalian isoforms I-XIV with a series of natural product polyphenols and phenolic acids. Bioorg Med Chem. 2010 Mar 15;18(6):2159-2164. DMX8BS5 RU https://pubmed.ncbi.nlm.nih.gov/20185318 DMX8BS5 DI DMX8BS5 DMX8BS5 DN ELLAGIC ACID DMX8BS5 MI TTSYM0R DMX8BS5 MN Carbonic anhydrase XII (CA-XII) DMX8BS5 MT DTT DMX8BS5 MA Inhibitor DMX8BS5 RN Carbonic anhydrase inhibitors. Inhibition of mammalian isoforms I-XIV with a series of natural product polyphenols and phenolic acids. Bioorg Med Chem. 2010 Mar 15;18(6):2159-2164. DMX8BS5 RU https://pubmed.ncbi.nlm.nih.gov/20185318 DMX8BS5 DI DMX8BS5 DMX8BS5 DN ELLAGIC ACID DMX8BS5 MI TTEYTKG DMX8BS5 MN Carbonic anhydrase XIV (CA-XIV) DMX8BS5 MT DTT DMX8BS5 MA Inhibitor DMX8BS5 RN Carbonic anhydrase inhibitors. Inhibition of mammalian isoforms I-XIV with a series of natural product polyphenols and phenolic acids. Bioorg Med Chem. 2010 Mar 15;18(6):2159-2164. DMX8BS5 RU https://pubmed.ncbi.nlm.nih.gov/20185318 DMX8BS5 DI DMX8BS5 DMX8BS5 DN ELLAGIC ACID DMX8BS5 MI TTER6YH DMX8BS5 MN Casein kinase II alpha (CSNK2A1) DMX8BS5 MT DTT DMX8BS5 MA Inhibitor DMX8BS5 RN Structural insight into human CK2alpha in complex with the potent inhibitor ellagic acid. Bioorg Med Chem Lett. 2009 Jun 1;19(11):2920-3. DMX8BS5 RU https://pubmed.ncbi.nlm.nih.gov/19414254 DMX8BS5 DI DMX8BS5 DMX8BS5 DN ELLAGIC ACID DMX8BS5 MI TTRSMW9 DMX8BS5 MN Glycogen synthase kinase-3 beta (GSK-3B) DMX8BS5 MT DTT DMX8BS5 MA Inhibitor DMX8BS5 RN Identification of ellagic acid as potent inhibitor of protein kinase CK2: a successful example of a virtual screening application. J Med Chem. 2006 Apr 20;49(8):2363-6. DMX8BS5 RU https://pubmed.ncbi.nlm.nih.gov/16610779 DMX8BS5 DI DMX8BS5 DMX8BS5 DN ELLAGIC ACID DMX8BS5 MI TTHYBIX DMX8BS5 MN Heat shock protein 70 (HSP70) DMX8BS5 MT DTT DMX8BS5 MA Inhibitor DMX8BS5 RN In silico identification and biochemical evaluation of novel inhibitors of NRH:quinone oxidoreductase 2 (NQO2). Bioorg Med Chem Lett. 2010 Dec 15;20(24):7331-6. DMX8BS5 RU https://pubmed.ncbi.nlm.nih.gov/21074425 DMX8BS5 DI DMX8BS5 DMX8BS5 DN ELLAGIC ACID DMX8BS5 MI TTHQZV7 DMX8BS5 MN Mothers against decapentaplegic homolog 3 (SMAD3) DMX8BS5 MT DTT DMX8BS5 MA Inhibitor DMX8BS5 RN In silico identification and biochemical evaluation of novel inhibitors of NRH:quinone oxidoreductase 2 (NQO2). Bioorg Med Chem Lett. 2010 Dec 15;20(24):7331-6. DMX8BS5 RU https://pubmed.ncbi.nlm.nih.gov/21074425 DMX8BS5 DI DMX8BS5 DMX8BS5 DN ELLAGIC ACID DMX8BS5 MI TTE14XG DMX8BS5 MN Squalene monooxygenase (SQLE) DMX8BS5 MT DTT DMX8BS5 MA Inhibitor DMX8BS5 RN Ellagitannins and hexahydroxydiphenoyl esters as inhibitors of vertebrate squalene epoxidase. J Nat Prod. 2001 Aug;64(8):1010-4. DMX8BS5 RU https://pubmed.ncbi.nlm.nih.gov/11520216 DMX8BS5 DI DMX8BS5 DMX8BS5 DN ELLAGIC ACID DMX8BS5 MI TTOU65C DMX8BS5 MN Tyrosine-protein kinase SYK (SYK) DMX8BS5 MT DTT DMX8BS5 MA Inhibitor DMX8BS5 RN Identification of ellagic acid as potent inhibitor of protein kinase CK2: a successful example of a virtual screening application. J Med Chem. 2006 Apr 20;49(8):2363-6. DMX8BS5 RU https://pubmed.ncbi.nlm.nih.gov/16610779 DMHPYSM DI DMHPYSM DMHPYSM DN Ellipticine DMHPYSM MI TT0IHXV DMHPYSM MN DNA topoisomerase II (TOP2) DMHPYSM MT DTT DMHPYSM MA Inhibitor DMHPYSM RN In vitro sensitivity of Trichomonas vaginalis to DNA topoisomerase II inhibitors. Southeast Asian J Trop Med Public Health. 2000 Mar;31(1):118-22. DMHPYSM RU https://pubmed.ncbi.nlm.nih.gov/11023077 DM2DERW DI DM2DERW DM2DERW DN ELN-864709 DM2DERW MI TT056SO DM2DERW MN Stress-activated protein kinase JNK3 (JNK3) DM2DERW MT DTT DM2DERW MA Inhibitor DM2DERW RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1498). DM2DERW RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1498 DM5G1SF DI DM5G1SF DM5G1SF DN ELND-007 DM5G1SF MI TTE4KHA DM5G1SF MN Amyloid beta A4 protein (APP) DM5G1SF MT DTT DM5G1SF MA Inhibitor DM5G1SF RN Inhibition of APP gamma-secretase restores Sonic Hedgehog signaling and neurogenesis in the Ts65Dn mouse model of Down syndrome. Neurobiology of Disease Volume 82, October 2015, Pages 385-396. DM5G1SF RU http://www.sciencedirect.com/science/article/pii/S096999611530022X DMQ63J2 DI DMQ63J2 DMQ63J2 DN EM-101 DMQ63J2 MI TTCJG29 DMQ63J2 MN Serine/threonine-protein kinase mTOR (mTOR) DMQ63J2 MT DTT DMQ63J2 MA Inhibitor DMQ63J2 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2109). DMQ63J2 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2109 DMZ2EL1 DI DMZ2EL1 DMZ2EL1 DN EM1396 DMZ2EL1 MI TT5ZWB6 DMZ2EL1 MN Dihydrodiol dehydrogenase type I (AKR1C3) DMZ2EL1 MT DTT DMZ2EL1 MA Inhibitor DMZ2EL1 RN Structure-based inhibitor design for an enzyme that binds different steroids: a potent inhibitor for human type 5 17beta-hydroxysteroid dehydrogenase. J Biol Chem. 2007 Mar 16;282(11):8368-79. DMZ2EL1 RU https://pubmed.ncbi.nlm.nih.gov/17166832 DMSLHDN DI DMSLHDN DMSLHDN DN EM-1424 DMSLHDN MI TT5ZWB6 DMSLHDN MN Dihydrodiol dehydrogenase type I (AKR1C3) DMSLHDN MT DTT DMSLHDN MA Inhibitor DMSLHDN RN Structure-based inhibitor design for an enzyme that binds different steroids: a potent inhibitor for human type 5 17beta-hydroxysteroid dehydrogenase. J Biol Chem. 2007 Mar 16;282(11):8368-79. DMSLHDN RU https://pubmed.ncbi.nlm.nih.gov/17166832 DM3RSYO DI DM3RSYO DM3RSYO DN EM-1745 DM3RSYO MI TTIWB6L DM3RSYO MN Estradiol 17 beta-dehydrogenase 1 (17-beta-HSD1) DM3RSYO MT DTT DM3RSYO MA Inhibitor DM3RSYO RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DM3RSYO RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMC4XJ6 DI DMC4XJ6 DMC4XJ6 DN EM-523 DMC4XJ6 MI TT953CX DMC4XJ6 MN Motilin receptor (MLNR) DMC4XJ6 MT DTT DMC4XJ6 MA Agonist DMC4XJ6 RN Desensitization of the human motilin receptor by motilides. J Pharmacol Exp Ther. 2005 Jun;313(3):1397-405. DMC4XJ6 RU https://pubmed.ncbi.nlm.nih.gov/15764739 DMFQX1U DI DMFQX1U DMFQX1U DN EMATE DMFQX1U MI TTANPDJ DMFQX1U MN Carbonic anhydrase II (CA-II) DMFQX1U MT DTT DMFQX1U MA Inhibitor DMFQX1U RN 2-substituted estradiol bis-sulfamates, multitargeted antitumor agents: synthesis, in vitro SAR, protein crystallography, and in vivo activity. J Med Chem. 2006 Dec 28;49(26):7683-96. DMFQX1U RU https://pubmed.ncbi.nlm.nih.gov/17181151 DMFQX1U DI DMFQX1U DMFQX1U DN EMATE DMFQX1U MI TTHM0R1 DMFQX1U MN Steryl-sulfatase (STS) DMFQX1U MT DTT DMFQX1U MA Inhibitor DMFQX1U RN Thiosemicarbazones of formyl benzoic acids as novel potent inhibitors of estrone sulfatase. J Med Chem. 2007 Jul 26;50(15):3661-6. DMFQX1U RU https://pubmed.ncbi.nlm.nih.gov/17580843 DMUH1JX DI DMUH1JX DMUH1JX DN EMC-0901 DMUH1JX MI TTDIGC1 DMUH1JX MN Dipeptidyl peptidase 4 (DPP-4) DMUH1JX MT DTT DMUH1JX MA Inhibitor DMUH1JX RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1612). DMUH1JX RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1612 DM4SEMA DI DM4SEMA DM4SEMA DN EMD 56551 DM4SEMA MI TTSQIFT DM4SEMA MN 5-HT 1A receptor (HTR1A) DM4SEMA MT DTT DM4SEMA MA Modulator DM4SEMA RN Diagnosis of migraine with aura, depression and anxiety from allelic variations in dopaminergic genes DM4SEMA RU https://www.google.com/patents/WO1998007426A1 DM3AGUQ DI DM3AGUQ DM3AGUQ DN EMD-386088 DM3AGUQ MI TTJS8PY DM3AGUQ MN 5-HT 6 receptor (HTR6) DM3AGUQ MT DTT DM3AGUQ MA Agonist DM3AGUQ RN 2-Alkyl-3-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indoles as novel 5-HT6 receptor agonists. Bioorg Med Chem Lett. 2005 Oct 1;15(19):4230-4. DM3AGUQ RU https://pubmed.ncbi.nlm.nih.gov/16055331 DM6O2BR DI DM6O2BR DM6O2BR DN EMPA DM6O2BR MI TT9N02I DM6O2BR MN Orexin receptor type 2 (HCRTR2) DM6O2BR MT DTT DM6O2BR MA Antagonist DM6O2BR RN Biochemical and behavioural characterization of EMPA, a novel high-affinity, selective antagonist for the OX(2) receptor. Br J Pharmacol. 2009 Apr;156(8):1326-41. DM6O2BR RU https://pubmed.ncbi.nlm.nih.gov/19751316 DMQLNZC DI DMQLNZC DMQLNZC DN Empagli ozin DMQLNZC MI TTLWPVF DMQLNZC MN Sodium/glucose cotransporter 2 (SGLT2) DMQLNZC MT DTT DMQLNZC MA Modulator DMQLNZC RN 2014 FDA drug approvals. Nat Rev Drug Discov. 2015 Feb;14(2):77-81. DMQLNZC RU https://pubmed.ncbi.nlm.nih.gov/25633781 DMASQWV DI DMASQWV DMASQWV DN enantio PAF C-16 DMASQWV MI TTQL5VC DMASQWV MN Platelet-activating factor receptor (PTAFR) DMASQWV MT DTT DMASQWV MA Agonist DMASQWV RN A radioreceptor binding assay for platelet-activating factor (PAF) using membranes from CHO cells expressing human PAF receptor. J Immunol Methods. 1995 Oct 26;186(2):225-31. DMASQWV RU https://pubmed.ncbi.nlm.nih.gov/7594622 DMUCZPJ DI DMUCZPJ DMUCZPJ DN ENDG-4010 DMUCZPJ MI TT3ZTGU DMUCZPJ MN Endothelin B receptor (EDNRB) DMUCZPJ MT DTT DMUCZPJ MA Modulator DMUCZPJ RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 220). DMUCZPJ RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=220 DM7RDGH DI DM7RDGH DM7RDGH DN ENDIANDRIN A DM7RDGH MI TTOZRK6 DM7RDGH MN Glucocorticoid receptor messenger RNA (GCR mRNA) DM7RDGH MT DTT DM7RDGH MA Inhibitor DM7RDGH RN Endiandrin A, a potent glucocorticoid receptor binder isolated from the Australian plant Endiandra anthropophagorum. J Nat Prod. 2007 Jul;70(7):1118-21. DM7RDGH RU https://pubmed.ncbi.nlm.nih.gov/17583952 DM4AI91 DI DM4AI91 DM4AI91 DN Endo-CD DM4AI91 MI TT63DI9 DM4AI91 MN Endostatin (COL18A1) DM4AI91 MT DTT DM4AI91 MA Modulator DM4AI91 RN Dual targeting of tumor angiogenesis and chemotherapy by endostatin-cytosine deaminase-uracil phosphoribosyltransferase.Mol Cancer Ther.2011 Aug;10(8):1327-36. DM4AI91 RU https://www.ncbi.nlm.nih.gov/pubmed/21610170 DMOQWBU DI DMOQWBU DMOQWBU DN ENDOMORPHIN 2 DMOQWBU MI TT27RFC DMOQWBU MN Opioid receptor delta (OPRD1) DMOQWBU MT DTT DMOQWBU MA Inhibitor DMOQWBU RN Synthesis and activity of endomorphin-2 and morphiceptin analogues with proline surrogates in position 2. Eur J Med Chem. 2010 Oct;45(10):4594-600. DMOQWBU RU https://pubmed.ncbi.nlm.nih.gov/20692738 DMOQWBU DI DMOQWBU DMOQWBU DN ENDOMORPHIN 2 DMOQWBU MI TTQW87Y DMOQWBU MN Opioid receptor kappa (OPRK1) DMOQWBU MT DTT DMOQWBU MA Inhibitor DMOQWBU RN Structure-activity study on the Phe side chain arrangement of endomorphins using conformationally constrained analogues. J Med Chem. 2004 Jan 29;47(3):735-43. DMOQWBU RU https://pubmed.ncbi.nlm.nih.gov/14736254 DMOQWBU DI DMOQWBU DMOQWBU DN ENDOMORPHIN 2 DMOQWBU MI TTKWM86 DMOQWBU MN Opioid receptor mu (MOP) DMOQWBU MT DTT DMOQWBU MA Inhibitor DMOQWBU RN Synthesis and activity of endomorphin-2 and morphiceptin analogues with proline surrogates in position 2. Eur J Med Chem. 2010 Oct;45(10):4594-600. DMOQWBU RU https://pubmed.ncbi.nlm.nih.gov/20692738 DMOQWBU DI DMOQWBU DMOQWBU DN ENDOMORPHIN 2 DMOQWBU MI TTZPO1L DMOQWBU MN Substance-P receptor (TACR1) DMOQWBU MT DTT DMOQWBU MA Inhibitor DMOQWBU RN Discovery of dipeptides with high affinity to the specific binding site for substance P1-7. J Med Chem. 2010 Mar 25;53(6):2383-9. DMOQWBU RU https://pubmed.ncbi.nlm.nih.gov/20178322 DMBJUEM DI DMBJUEM DMBJUEM DN ENDOMORPHIN-1 DMBJUEM MI TT27RFC DMBJUEM MN Opioid receptor delta (OPRD1) DMBJUEM MT DTT DMBJUEM MA Inhibitor DMBJUEM RN New endomorphin analogues containing alicyclic beta-amino acids: influence on bioactive conformation and pharmacological profile. J Med Chem. 2008 Jul 24;51(14):4270-9. DMBJUEM RU https://pubmed.ncbi.nlm.nih.gov/18572932 DMBJUEM DI DMBJUEM DMBJUEM DN ENDOMORPHIN-1 DMBJUEM MI TTQW87Y DMBJUEM MN Opioid receptor kappa (OPRK1) DMBJUEM MT DTT DMBJUEM MA Inhibitor DMBJUEM RN Structure-activity study on the Phe side chain arrangement of endomorphins using conformationally constrained analogues. J Med Chem. 2004 Jan 29;47(3):735-43. DMBJUEM RU https://pubmed.ncbi.nlm.nih.gov/14736254 DMBJUEM DI DMBJUEM DMBJUEM DN ENDOMORPHIN-1 DMBJUEM MI TTKWM86 DMBJUEM MN Opioid receptor mu (MOP) DMBJUEM MT DTT DMBJUEM MA Inhibitor DMBJUEM RN Synthesis and evaluation of new endomorphin analogues modified at the Pro(2) residue. Bioorg Med Chem Lett. 2009 Aug 1;19(15):4115-8. DMBJUEM RU https://pubmed.ncbi.nlm.nih.gov/19560919 DMI2RQS DI DMI2RQS DMI2RQS DN Endomorphins DMI2RQS MI TTKWM86 DMI2RQS MN Opioid receptor mu (MOP) DMI2RQS MT DTT DMI2RQS MA Modulator DMI2RQS RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 319). DMI2RQS RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=319 DMOEIYQ DI DMOEIYQ DMOEIYQ DN Endothelin-2 DMOEIYQ MI TTKRD0G DMOEIYQ MN Endothelin A receptor (EDNRA) DMOEIYQ MT DTT DMOEIYQ MA Inhibitor DMOEIYQ RN 5-OHKF and NorKA, depsipeptides from a Hawaiian collection of Bryopsis pennata: binding properties for NorKA to the human neuropeptide Y Y1 receptor. J Nat Prod. 2009 Dec;72(12):2172-6. DMOEIYQ RU https://pubmed.ncbi.nlm.nih.gov/19916528 DM0DM6X DI DM0DM6X DM0DM6X DN Endothelin-3 DM0DM6X MI TT3ZTGU DM0DM6X MN Endothelin B receptor (EDNRB) DM0DM6X MT DTT DM0DM6X MA Inhibitor DM0DM6X RN cis-4-(Piperazin-1-yl)-5,6,7a,8,9,10,11,11a-octahydrobenzofuro[2,3-h]quinazolin-2-amine (A-987306), a new histamine H4R antagonist that blocks pain... J Med Chem. 2008 Nov 27;51(22):7094-8. DM0DM6X RU https://pubmed.ncbi.nlm.nih.gov/18983139 DM0STFR DI DM0STFR DM0STFR DN ENHYDRIN DM0STFR MI TTSXVID DM0STFR MN Nuclear factor NF-kappa-B (NFKB) DM0STFR MT DTT DM0STFR MA Inhibitor DM0STFR RN Development of a structural model for NF-kappaB inhibition of sesquiterpene lactones using self-organizing neural networks. J Med Chem. 2006 Apr 6;49(7):2241-52. DM0STFR RU https://pubmed.ncbi.nlm.nih.gov/16570920 DMYJ8ZB DI DMYJ8ZB DMYJ8ZB DN Enoxaprin DMYJ8ZB MI TT6L509 DMYJ8ZB MN Coagulation factor IIa (F2) DMYJ8ZB MT DTT DMYJ8ZB MA Inhibitor DMYJ8ZB RN Low molecular weight heparins and their use in obstetrics and gynecology. Obstet Gynecol Surv. 1994 Jun;49(6):424-31. DMYJ8ZB RU https://pubmed.ncbi.nlm.nih.gov/8090379 DMSPIF2 DI DMSPIF2 DMSPIF2 DN EP 157 DMSPIF2 MI TTOFYT1 DMSPIF2 MN Prostacyclin receptor (PTGIR) DMSPIF2 MT DTT DMSPIF2 MA Agonist DMSPIF2 RN Prostaglandin endoperoxide analogues which are both thromboxane receptor antagonists and prostacyclin mimetics. Br J Pharmacol. 1986 Mar;87(3):543-51. DMSPIF2 RU https://pubmed.ncbi.nlm.nih.gov/3026540 DM7YION DI DM7YION DM7YION DN EP 171 DM7YION MI TT2O84V DM7YION MN Thromboxane A2 receptor (TBXA2R) DM7YION MT DTT DM7YION MA Agonist DM7YION RN EP 171: a high affinity thromboxane A2-mimetic, the actions of which are slowly reversed by receptor blockade. Br J Pharmacol. 1989 Apr;96(4):875-87. DM7YION RU https://pubmed.ncbi.nlm.nih.gov/2743082 DMAURX5 DI DMAURX5 DMAURX5 DN EP-200 DMAURX5 MI TT2O4W9 DMAURX5 MN Luteinizing hormone receptor (LHCGR) DMAURX5 MT DTT DMAURX5 MA Modulator DMAURX5 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 254). DMAURX5 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=254 DMHN82B DI DMHN82B DMHN82B DN EP-37 DMHN82B MI TTCIHJA DMHN82B MN Coagulation factor Xa (F10) DMHN82B MT DTT DMHN82B MA Antagonist DMHN82B RN Semuloparin for the prevention of venous thromboembolic events in cancer patients. Drugs Today (Barc). 2012 Jul;48(7):451-7. DMHN82B RU https://pubmed.ncbi.nlm.nih.gov/22844656 DM01MW7 DI DM01MW7 DM01MW7 DN EPALRESTATE DM01MW7 MI TTFBNVI DM01MW7 MN Aldose reductase (AKR1B1) DM01MW7 MT DTT DM01MW7 MA Inhibitor DM01MW7 RN Erigeroflavanone, a flavanone derivative from the flowers of Erigeron annuus with protein glycation and aldose reductase inhibitory activity. J Nat Prod. 2008 Apr;71(4):713-5. DM01MW7 RU https://pubmed.ncbi.nlm.nih.gov/18298080 DMBLSX3 DI DMBLSX3 DMBLSX3 DN EPB-415 DMBLSX3 MI TTCAQMW DMBLSX3 MN Inosine-5'-monophosphate dehydrogenase (IMPDH) DMBLSX3 MT DTT DMBLSX3 MA Modulator DMBLSX3 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2625). DMBLSX3 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2625 DMT7RXZ DI DMT7RXZ DMT7RXZ DN E-pentenylbutanedioic acid 32 DMT7RXZ MI TT5VER7 DMT7RXZ MN Bacterial Undecaprenyl pyrophosphate synthetase (Bact ispU) DMT7RXZ MT DTT DMT7RXZ MA Inhibitor DMT7RXZ RN Synthesis and biological activity of isopentenyl diphosphate analogues. Bioorg Med Chem. 2004 Feb 15;12(4):763-70. DMT7RXZ RU https://pubmed.ncbi.nlm.nih.gov/14759736 DM3F427 DI DM3F427 DM3F427 DN EphB4-131 DM3F427 MI TTI4ZX2 DM3F427 MN Ephrin type-B receptor 4 (EPHB4) DM3F427 MT DTT DM3F427 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1833). DM3F427 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1833 DMYWV81 DI DMYWV81 DMYWV81 DN EPI-001 DMYWV81 MI TTS64P2 DMYWV81 MN Androgen receptor (AR) DMYWV81 MT DTT DMYWV81 MA Modulator DMYWV81 RN EPI-001 is a selective peroxisome proliferator-activated receptor-gamma modulator with inhibitory effects on androgen receptor expression and activity in prostate cancer. Oncotarget. 2015 Feb 28;6(6):3811-24. DMYWV81 RU https://pubmed.ncbi.nlm.nih.gov/25669987 DM72DO1 DI DM72DO1 DM72DO1 DN EPI-0030 DM72DO1 MI TTUTJGQ DM72DO1 MN Vascular endothelial growth factor receptor 2 (KDR) DM72DO1 MT DTT DM72DO1 MA Modulator DM72DO1 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1813). DM72DO1 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1813 DMAGZD8 DI DMAGZD8 DMAGZD8 DN Epibatidine DMAGZD8 MI TTJSZTB DMAGZD8 MN Nicotinic acetylcholine receptor (nAChR) DMAGZD8 MT DTT DMAGZD8 MA Agonist DMAGZD8 RN The potential of subtype-selective neuronal nicotinic acetylcholine receptor agonists as therapeutic agents. Life Sci. 1998;62(17-18):1601-6. DMAGZD8 RU https://pubmed.ncbi.nlm.nih.gov/9585143 DMFMWA7 DI DMFMWA7 DMFMWA7 DN EpiCept DMFMWA7 MI TT85JO3 DMFMWA7 MN 5-HT receptor (5HTR) DMFMWA7 MT DTT DMFMWA7 MA Antagonist DMFMWA7 RN Emerging therapies for neuropathic pain. Expert Opin Emerg Drugs. 2005 Feb;10(1):95-108. DMFMWA7 RU https://pubmed.ncbi.nlm.nih.gov/15757406 DMGKIYE DI DMGKIYE DMGKIYE DN EPIDEPRIDE DMGKIYE MI TTEX248 DMGKIYE MN Dopamine D2 receptor (D2R) DMGKIYE MT DTT DMGKIYE MA Inhibitor DMGKIYE RN Fluorinated and iodinated dopamine agents: D2 imaging agents for PET and SPECT. J Med Chem. 1993 Jan 22;36(2):221-8. DMGKIYE RU https://pubmed.ncbi.nlm.nih.gov/8093734 DMVZW92 DI DMVZW92 DMVZW92 DN Epierenone DMVZW92 MI TTKPW01 DMVZW92 MN Androgen receptor messenger RNA (AR mRNA) DMVZW92 MT DTT DMVZW92 MA Inhibitor DMVZW92 RN (S)-N-{3-[1-cyclopropyl-1-(2,4-difluoro-phenyl)-ethyl]-1H-indol-7-yl}-methanesulfonamide: a potent, nonsteroidal, functional antagonist of the mine... J Med Chem. 2007 Dec 27;50(26):6443-5. DMVZW92 RU https://pubmed.ncbi.nlm.nih.gov/18038968 DMVZW92 DI DMVZW92 DMVZW92 DN Epierenone DMVZW92 MI TTOZRK6 DMVZW92 MN Glucocorticoid receptor messenger RNA (GCR mRNA) DMVZW92 MT DTT DMVZW92 MA Inhibitor DMVZW92 RN (S)-N-{3-[1-cyclopropyl-1-(2,4-difluoro-phenyl)-ethyl]-1H-indol-7-yl}-methanesulfonamide: a potent, nonsteroidal, functional antagonist of the mine... J Med Chem. 2007 Dec 27;50(26):6443-5. DMVZW92 RU https://pubmed.ncbi.nlm.nih.gov/18038968 DMVZW92 DI DMVZW92 DMVZW92 DN Epierenone DMVZW92 MI TT26PHO DMVZW92 MN Mineralocorticoid receptor (MR) DMVZW92 MT DTT DMVZW92 MA Inhibitor DMVZW92 RN (S)-N-{3-[1-cyclopropyl-1-(2,4-difluoro-phenyl)-ethyl]-1H-indol-7-yl}-methanesulfonamide: a potent, nonsteroidal, functional antagonist of the mine... J Med Chem. 2007 Dec 27;50(26):6443-5. DMVZW92 RU https://pubmed.ncbi.nlm.nih.gov/18038968 DMQAEU8 DI DMQAEU8 DMQAEU8 DN EPIMER A DMQAEU8 MI TTY6O0Q DMQAEU8 MN Calcitonin gene-related peptide receptor (CGRPR) DMQAEU8 MT DTT DMQAEU8 MA Inhibitor DMQAEU8 RN The identification of potent, orally bioavailable tricyclic CGRP receptor antagonists. Bioorg Med Chem Lett. 2009 Aug 15;19(16):4740-2. DMQAEU8 RU https://pubmed.ncbi.nlm.nih.gov/19577468 DMW271Q DI DMW271Q DMW271Q DN epipregnanolone sulphate DMW271Q MI TTO3TD8 DMW271Q MN Long transient receptor potential channel 3 (TRPM3) DMW271Q MT DTT DMW271Q MA Activator DMW271Q RN Cis-isomerism and other chemical requirements of steroidal agonists and partial agonists acting at TRPM3 channels. Br J Pharmacol. 2010 Sep;161(2):430-41. DMW271Q RU https://pubmed.ncbi.nlm.nih.gov/20735426 DM1C8FW DI DM1C8FW DM1C8FW DN Epitinib DM1C8FW MI TTGKNB4 DM1C8FW MN Epidermal growth factor receptor (EGFR) DM1C8FW MT DTT DM1C8FW MA Inhibitor DM1C8FW RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1797). DM1C8FW RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1797 DMVOD03 DI DMVOD03 DMVOD03 DN Eplerenone DMVOD03 MI TT9P1CK DMVOD03 MN HUMAN mineralocorticoid receptor (MR) DMVOD03 MT DTT DMVOD03 MA Antagonist DMVOD03 RN Network-based drug repurposing for novel coronavirus 2019-nCoV/SARS-CoV-2. Cell Discov. 2020 Mar 16;6:14. DMVOD03 RU https://pubmed.ncbi.nlm.nih.gov/32194980 DMDOR0L DI DMDOR0L DMDOR0L DN EPLIVANSERIN MESILATE DMDOR0L MI TTJQOD7 DMDOR0L MN 5-HT 2A receptor (HTR2A) DMDOR0L MT DTT DMDOR0L MA Modulator DMDOR0L RN Role of 5-HT2A receptor antagonists in the treatment of insomnia DMDOR0L RU https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3630942 DMP2QF0 DI DMP2QF0 DMP2QF0 DN EPO peptide mimetics DMP2QF0 MI TTAUX24 DMP2QF0 MN Erythropoietin Receptor (EPOR) DMP2QF0 MT DTT DMP2QF0 MA Modulator DMP2QF0 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1718). DMP2QF0 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1718 DMHQDLX DI DMHQDLX DMHQDLX DN EPO-derived peptide DMHQDLX MI TTAUX24 DMHQDLX MN Erythropoietin Receptor (EPOR) DMHQDLX MT DTT DMHQDLX MA Modulator DMHQDLX RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1718). DMHQDLX RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1718 DMV8PB4 DI DMV8PB4 DMV8PB4 DN Epostane DMV8PB4 MI TTZT9R2 DMV8PB4 MN Hydroxysteroid dehydrogenase 3-beta (HSD3B) DMV8PB4 MT DTT DMV8PB4 MA Inhibitor DMV8PB4 RN Termination of early pregnancy by the 3 beta-hydroxysteroid dehydrogenase inhibitor epostane. N Engl J Med. 1988 Sep 29;319(13):813-7. DMV8PB4 RU https://pubmed.ncbi.nlm.nih.gov/3166108 DMK3VID DI DMK3VID DMK3VID DN EPPTB DMK3VID MI TTIU98M DMK3VID MN Trace amine-associated receptor-1 (TAAR1) DMK3VID MT DTT DMK3VID MA Antagonist DMK3VID RN The selective antagonist EPPTB reveals TAAR1-mediated regulatory mechanisms in dopaminergic neurons of the mesolimbic system. Proc Natl Acad Sci U S A. 2009 Nov 24;106(47):20081-6. DMK3VID RU https://pubmed.ncbi.nlm.nih.gov/19892733 DMLN4V5 DI DMLN4V5 DMLN4V5 DN EPZ-004777 DMLN4V5 MI TTSZ8T1 DMLN4V5 MN Histone-lysine N-methyltransferase (HLNM) DMLN4V5 MT DTT DMLN4V5 MA Inhibitor DMLN4V5 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7377). DMLN4V5 RU http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=7377 DMYISTE DI DMYISTE DMYISTE DN EPZ005687 DMYISTE MI TT9MZCQ DMYISTE MN Enhancer of zeste homolog 2 (EZH2) DMYISTE MT DTT DMYISTE MA Inhibitor DMYISTE RN A selective inhibitor of EZH2 blocks H3K27 methylation and kills mutant lymphoma cells. Nat Chem Biol. 2012 Nov;8(11):890-6. DMYISTE RU https://pubmed.ncbi.nlm.nih.gov/23023262 DM3INX7 DI DM3INX7 DM3INX7 DN EPZ015666 DM3INX7 MI TTR1D7X DM3INX7 MN Protein arginine methyltransferase 5 (PRMT5) DM3INX7 MT DTT DM3INX7 MA Inhibitor DM3INX7 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1256). DM3INX7 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1256 DM2KMNU DI DM2KMNU DM2KMNU DN EQ-1280 DM2KMNU MI TTN7BL9 DM2KMNU MN Corticosteroid 11-beta-dehydrogenase 1 (HSD11B1) DM2KMNU MT DTT DM2KMNU MA Inhibitor DM2KMNU RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2763). DM2KMNU RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2763 DMHO56W DI DMHO56W DMHO56W DN Equilenin DMHO56W MI DE4LYSA DMHO56W MN Cytochrome P450 3A4 (CYP3A4) DMHO56W MT DME DMHO56W MA Metabolism DMHO56W RN The naphthol selective estrogen receptor modulator (SERM), LY2066948, is oxidized to an o-quinone analogous to the naphthol equine estrogen, equilenin. Chem Biol Interact. 2012 Mar 5;196(1-2):1-10. DMHO56W RU https://www.ncbi.nlm.nih.gov/pubmed/?term=22290292 DMHO56W DI DMHO56W DMHO56W DN Equilenin DMHO56W MI TTZT9R2 DMHO56W MN Hydroxysteroid dehydrogenase 3-beta (HSD3B) DMHO56W MT DTT DMHO56W MA Inhibitor DMHO56W RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMHO56W RU https://pubmed.ncbi.nlm.nih.gov/17139284 DM9PT03 DI DM9PT03 DM9PT03 DN Equilin DM9PT03 MI TTIWB6L DM9PT03 MN Estradiol 17 beta-dehydrogenase 1 (17-beta-HSD1) DM9PT03 MT DTT DM9PT03 MA Inhibitor DM9PT03 RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DM9PT03 RU https://pubmed.ncbi.nlm.nih.gov/17139284 DM2Q19U DI DM2Q19U DM2Q19U DN Equilin DM2Q19U MI TTAHMI6 DM2Q19U MN HUMAN estrogen receptor (ESR1) DM2Q19U MT DTT DM2Q19U MA Inhibitor DM2Q19U RN Prevention and therapy of COVID-19 via exogenous estrogen treatment for both male and female patients. J Pharm Pharm Sci. 2020;23(1):75-85. DM2Q19U RU https://pubmed.ncbi.nlm.nih.gov/32324533 DMIQ801 DI DMIQ801 DMIQ801 DN ER-119884 DMIQ801 MI TTFQEO5 DMIQ801 MN Squalene synthetase (FDFT1) DMIQ801 MT DTT DMIQ801 MA Inhibitor DMIQ801 RN Kinetic characterization of squalene synthase from Trypanosoma cruzi: selective inhibition by quinuclidine derivatives. Antimicrob Agents Chemother. 2007 Jun;51(6):2123-9. DMIQ801 RU https://pubmed.ncbi.nlm.nih.gov/17371809 DMUNO4R DI DMUNO4R DMUNO4R DN ER-21018 DMUNO4R MI TT07C3Y DMUNO4R MN 5-HT 4 receptor (HTR4) DMUNO4R MT DTT DMUNO4R MA Agonist DMUNO4R RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 9). DMUNO4R RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=9 DMAO6JS DI DMAO6JS DMAO6JS DN ER-23006 DMAO6JS MI TTMXGCW DMAO6JS MN Adrenergic receptor beta-3 (ADRB3) DMAO6JS MT DTT DMAO6JS MA Modulator DMAO6JS RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 29). DMAO6JS RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=29 DMSG91J DI DMSG91J DMSG91J DN ER819762 DMSG91J MI TT79WV3 DMSG91J MN Prostaglandin E2 receptor EP4 (PTGER4) DMSG91J MT DTT DMSG91J MA Antagonist DMSG91J RN A novel antagonist of the prostaglandin E(2) EP(4) receptor inhibits Th1 differentiation and Th17 expansion and is orally active in arthritis models. Br J Pharmacol. 2010 May;160(2):292-310. DMSG91J RU https://pubmed.ncbi.nlm.nih.gov/20423341 DMYRDBX DI DMYRDBX DMYRDBX DN ERB-002 DMYRDBX MI TTOM3J0 DMYRDBX MN Estrogen receptor beta (ESR2) DMYRDBX MT DTT DMYRDBX MA Agonist DMYRDBX RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 621). DMYRDBX RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=621 DMD3BEQ DI DMD3BEQ DMD3BEQ DN ERIODICTYOL DMD3BEQ MI TTI84H7 DMD3BEQ MN Cytochrome P450 1B1 (CYP1B1) DMD3BEQ MT DTT DMD3BEQ MA Inhibitor DMD3BEQ RN Selective inhibition of methoxyflavonoids on human CYP1B1 activity. Bioorg Med Chem. 2010 Sep 1;18(17):6310-5. DMD3BEQ RU https://pubmed.ncbi.nlm.nih.gov/20696580 DMB3ROZ DI DMB3ROZ DMB3ROZ DN ERK inhibitor III DMB3ROZ MI TT4TQBX DMB3ROZ MN Extracellular signal-regulated kinase 2 (ERK2) DMB3ROZ MT DTT DMB3ROZ MA Inhibitor DMB3ROZ RN Characterization of ATP-independent ERK inhibitors identified through in silico analysis of the active ERK2 structure. Bioorg Med Chem Lett. 2006 Dec 15;16(24):6281-7. DMB3ROZ RU https://pubmed.ncbi.nlm.nih.gov/17000106 DM27FRY DI DM27FRY DM27FRY DN Erybreadin b DM27FRY MI TTELIN2 DM27FRY MN PTPN1 messenger RNA (PTPN1 mRNA) DM27FRY MT DTT DM27FRY MA Inhibitor DM27FRY RN Cytotoxic and PTP1B inhibitory activities from Erythrina abyssinica. Bioorg Med Chem Lett. 2009 Dec 1;19(23):6745-9. DM27FRY RU https://pubmed.ncbi.nlm.nih.gov/19836230 DMNS976 DI DMNS976 DMNS976 DN Erybreadin C DMNS976 MI TTELIN2 DMNS976 MN PTPN1 messenger RNA (PTPN1 mRNA) DMNS976 MT DTT DMNS976 MA Inhibitor DMNS976 RN Cytotoxic and PTP1B inhibitory activities from Erythrina abyssinica. Bioorg Med Chem Lett. 2009 Dec 1;19(23):6745-9. DMNS976 RU https://pubmed.ncbi.nlm.nih.gov/19836230 DMYG7BM DI DMYG7BM DMYG7BM DN Erybreadin D DMYG7BM MI TTELIN2 DMYG7BM MN PTPN1 messenger RNA (PTPN1 mRNA) DMYG7BM MT DTT DMYG7BM MA Inhibitor DMYG7BM RN Cytotoxic and PTP1B inhibitory activities from Erythrina abyssinica. Bioorg Med Chem Lett. 2009 Dec 1;19(23):6745-9. DMYG7BM RU https://pubmed.ncbi.nlm.nih.gov/19836230 DMCHVIG DI DMCHVIG DMCHVIG DN ERYSTAGALLIN A DMCHVIG MI TT50QJ3 DMCHVIG MN Influenza Neuraminidase (Influ NA) DMCHVIG MT DTT DMCHVIG MA Inhibitor DMCHVIG RN Prenylated pterocarpans as bacterial neuraminidase inhibitors. Bioorg Med Chem. 2010 May 1;18(9):3335-44. DMCHVIG RU https://pubmed.ncbi.nlm.nih.gov/20363636 DMVA9F7 DI DMVA9F7 DMVA9F7 DN Erysubin D DMVA9F7 MI TT50QJ3 DMVA9F7 MN Influenza Neuraminidase (Influ NA) DMVA9F7 MT DTT DMVA9F7 MA Inhibitor DMVA9F7 RN Prenylated pterocarpans as bacterial neuraminidase inhibitors. Bioorg Med Chem. 2010 May 1;18(9):3335-44. DMVA9F7 RU https://pubmed.ncbi.nlm.nih.gov/20363636 DMXWK1A DI DMXWK1A DMXWK1A DN Erysubin E DMXWK1A MI TT50QJ3 DMXWK1A MN Influenza Neuraminidase (Influ NA) DMXWK1A MT DTT DMXWK1A MA Inhibitor DMXWK1A RN Prenylated pterocarpans as bacterial neuraminidase inhibitors. Bioorg Med Chem. 2010 May 1;18(9):3335-44. DMXWK1A RU https://pubmed.ncbi.nlm.nih.gov/20363636 DMXWK1A DI DMXWK1A DMXWK1A DN Erysubin E DMXWK1A MI TTELIN2 DMXWK1A MN PTPN1 messenger RNA (PTPN1 mRNA) DMXWK1A MT DTT DMXWK1A MA Inhibitor DMXWK1A RN Cytotoxic and PTP1B inhibitory activities from Erythrina abyssinica. Bioorg Med Chem Lett. 2009 Dec 1;19(23):6745-9. DMXWK1A RU https://pubmed.ncbi.nlm.nih.gov/19836230 DMLT7FQ DI DMLT7FQ DMLT7FQ DN Erythose-4-Phosphate DMLT7FQ MI TTVNA43 DMLT7FQ MN Bacterial Deoxy-D-manno-octulosonate 8-phosphate synthase (Bact kdsA) DMLT7FQ MT DTT DMLT7FQ MA Inhibitor DMLT7FQ RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMLT7FQ RU https://pubmed.ncbi.nlm.nih.gov/17139284 DM5GEUN DI DM5GEUN DM5GEUN DN ERYTHRIBYSSIN A DM5GEUN MI TTELIN2 DM5GEUN MN PTPN1 messenger RNA (PTPN1 mRNA) DM5GEUN MT DTT DM5GEUN MA Inhibitor DM5GEUN RN Cytotoxic and PTP1B inhibitory activities from Erythrina abyssinica. Bioorg Med Chem Lett. 2009 Dec 1;19(23):6745-9. DM5GEUN RU https://pubmed.ncbi.nlm.nih.gov/19836230 DMBVSKZ DI DMBVSKZ DMBVSKZ DN Erythribyssin D DMBVSKZ MI TT50QJ3 DMBVSKZ MN Influenza Neuraminidase (Influ NA) DMBVSKZ MT DTT DMBVSKZ MA Inhibitor DMBVSKZ RN Prenylated pterocarpans as bacterial neuraminidase inhibitors. Bioorg Med Chem. 2010 May 1;18(9):3335-44. DMBVSKZ RU https://pubmed.ncbi.nlm.nih.gov/20363636 DMUL4AP DI DMUL4AP DMUL4AP DN Erythribyssin L DMUL4AP MI TT50QJ3 DMUL4AP MN Influenza Neuraminidase (Influ NA) DMUL4AP MT DTT DMUL4AP MA Inhibitor DMUL4AP RN Prenylated pterocarpans as bacterial neuraminidase inhibitors. Bioorg Med Chem. 2010 May 1;18(9):3335-44. DMUL4AP RU https://pubmed.ncbi.nlm.nih.gov/20363636 DMWEK8I DI DMWEK8I DMWEK8I DN Erythribyssin M DMWEK8I MI TT50QJ3 DMWEK8I MN Influenza Neuraminidase (Influ NA) DMWEK8I MT DTT DMWEK8I MA Inhibitor DMWEK8I RN Prenylated pterocarpans as bacterial neuraminidase inhibitors. Bioorg Med Chem. 2010 May 1;18(9):3335-44. DMWEK8I RU https://pubmed.ncbi.nlm.nih.gov/20363636 DM8LEJ4 DI DM8LEJ4 DM8LEJ4 DN Erythribyssin O DM8LEJ4 MI TT50QJ3 DM8LEJ4 MN Influenza Neuraminidase (Influ NA) DM8LEJ4 MT DTT DM8LEJ4 MA Inhibitor DM8LEJ4 RN Prenylated pterocarpans as bacterial neuraminidase inhibitors. Bioorg Med Chem. 2010 May 1;18(9):3335-44. DM8LEJ4 RU https://pubmed.ncbi.nlm.nih.gov/20363636 DM8UVI3 DI DM8UVI3 DM8UVI3 DN Erythro-3,4-dichloromethylphenidate hydrochloride DM8UVI3 MI TTVBI8W DM8UVI3 MN Dopamine transporter (DAT) DM8UVI3 MT DTT DM8UVI3 MA Inhibitor DM8UVI3 RN Synthesis and pharmacology of site-specific cocaine abuse treatment agents: restricted rotation analogues of methylphenidate. J Med Chem. 2007 May 31;50(11):2718-31. DM8UVI3 RU https://pubmed.ncbi.nlm.nih.gov/17489581 DM8UVI3 DI DM8UVI3 DM8UVI3 DN Erythro-3,4-dichloromethylphenidate hydrochloride DM8UVI3 MI TT3ROYC DM8UVI3 MN Serotonin transporter (SERT) DM8UVI3 MT DTT DM8UVI3 MA Inhibitor DM8UVI3 RN Synthesis and pharmacology of site-specific cocaine abuse treatment agents: restricted rotation analogues of methylphenidate. J Med Chem. 2007 May 31;50(11):2718-31. DM8UVI3 RU https://pubmed.ncbi.nlm.nih.gov/17489581 DM0PHEW DI DM0PHEW DM0PHEW DN Erythromycin salnacedin DM0PHEW MI TTUWYEA DM0PHEW MN Bacterial 50S ribosomal RNA (Bact 50S rRNA) DM0PHEW MT DTT DM0PHEW MA Modulator DM0PHEW RN The ChEMBL database in 2017. Nucleic Acids Res. 2017 Jan 4;45(D1):D945-D954. DM0PHEW RU https://www.ncbi.nlm.nih.gov/pubmed/27899562 DM0PHEW DI DM0PHEW DM0PHEW DN Erythromycin salnacedin DM0PHEW MI DE4LYSA DM0PHEW MN Cytochrome P450 3A4 (CYP3A4) DM0PHEW MT DME DM0PHEW MA Metabolism DM0PHEW RN Effect of the CYP3A4 inhibitor erythromycin on the pharmacokinetics of lignocaine and its pharmacologically active metabolites in subjects with normal and impaired liver function. Br J Clin Pharmacol. 2003 Jan;55(1):86-93. DM0PHEW RU https://www.ncbi.nlm.nih.gov/pubmed/?term=12534644 DM0PHEW DI DM0PHEW DM0PHEW DN Erythromycin salnacedin DM0PHEW MI DEIBDNY DM0PHEW MN Cytochrome P450 3A5 (CYP3A5) DM0PHEW MT DME DM0PHEW MA Metabolism DM0PHEW RN Differential regulation of CYP3A4 and CYP3A5 and its implication in drug discovery. Curr Drug Metab. 2017;18(12):1095-1105. DM0PHEW RU https://www.ncbi.nlm.nih.gov/pubmed/?term=28558634 DM0PHEW DI DM0PHEW DM0PHEW DN Erythromycin salnacedin DM0PHEW MI DERD86B DM0PHEW MN Cytochrome P450 3A7 (CYP3A7) DM0PHEW MT DME DM0PHEW MA Metabolism DM0PHEW RN Helices F-G are important for the substrate specificities of CYP3A7. Drug Metab Dispos. 2007 Mar;35(3):484-92. DM0PHEW RU https://www.ncbi.nlm.nih.gov/pubmed/?term=17178770 DM3R8YL DI DM3R8YL DM3R8YL DN Erythropoietin DM3R8YL MI TTAUX24 DM3R8YL MN Erythropoietin Receptor (EPOR) DM3R8YL MT DTT DM3R8YL MA Stimulator DM3R8YL RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1718). DM3R8YL RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1718 DM8BS5C DI DM8BS5C DM8BS5C DN Eryvarin D DM8BS5C MI TT50QJ3 DM8BS5C MN Influenza Neuraminidase (Influ NA) DM8BS5C MT DTT DM8BS5C MA Inhibitor DM8BS5C RN Prenylated pterocarpans as bacterial neuraminidase inhibitors. Bioorg Med Chem. 2010 May 1;18(9):3335-44. DM8BS5C RU https://pubmed.ncbi.nlm.nih.gov/20363636 DMSNM5O DI DMSNM5O DMSNM5O DN ES-6864 DMSNM5O MI TTB2MXP DMSNM5O MN Angiotensinogenase renin (REN) DMSNM5O MT DTT DMSNM5O MA Inhibitor DMSNM5O RN A highly potent and long-acting oral inhibitor of human renin. Hypertension. 1988 Jun;11(6 Pt 2):708-12. DMSNM5O RU https://pubmed.ncbi.nlm.nih.gov/3134306 DMIVZ3W DI DMIVZ3W DMIVZ3W DN ES-936 DMIVZ3W MI TT8XK6L DMIVZ3W MN Quinone reductase 1 (NQO1) DMIVZ3W MT DTT DMIVZ3W MA Inhibitor DMIVZ3W RN Synthesis and evaluation of 3-aryloxymethyl-1,2-dimethylindole-4,7-diones as mechanism-based inhibitors of NAD(P)H:quinone oxidoreductase 1 (NQO1) ... J Med Chem. 2007 Nov 15;50(23):5780-9. DMIVZ3W RU https://pubmed.ncbi.nlm.nih.gov/17944451 DMPTDHC DI DMPTDHC DMPTDHC DN ESCHOLTZINE DMPTDHC MI TTSQIFT DMPTDHC MN 5-HT 1A receptor (HTR1A) DMPTDHC MT DTT DMPTDHC MA Inhibitor DMPTDHC RN Alkaloids from Eschscholzia californica and their capacity to inhibit binding of [3H]8-Hydroxy-2-(di-N-propylamino)tetralin to 5-HT1A receptors in ... J Nat Prod. 2006 Mar;69(3):432-5. DMPTDHC RU https://pubmed.ncbi.nlm.nih.gov/16562853 DMANEC9 DI DMANEC9 DMANEC9 DN Esculin DMANEC9 MI DEX0NP3 DMANEC9 MN Beta-glucosidase (bglA) DMANEC9 MT DME DMANEC9 MA Metabolism DMANEC9 RN A prodrug approach to the use of coumarins as potential therapeutics for superficial mycoses. PLoS One. 2013 Nov 18;8(11):e80760. DMANEC9 RU https://pubmed.ncbi.nlm.nih.gov/24260474 DMANEC9 DI DMANEC9 DMANEC9 DN Esculin DMANEC9 MI DESLN2J DMANEC9 MN Beta-glucosidase (bglA) DMANEC9 MT DME DMANEC9 MA Metabolism DMANEC9 RN Physiological and molecular characterization of atypical isolates of Malassezia furfur. J Clin Microbiol. 2009 Jan;47(1):48-53. DMANEC9 RU https://pubmed.ncbi.nlm.nih.gov/18971363 DMANEC9 DI DMANEC9 DMANEC9 DN Esculin DMANEC9 MI DEAZSKX DMANEC9 MN Beta-glucosidase (bglA) DMANEC9 MT DME DMANEC9 MA Metabolism DMANEC9 RN A prodrug approach to the use of coumarins as potential therapeutics for superficial mycoses. PLoS One. 2013 Nov 18;8(11):e80760. DMANEC9 RU https://pubmed.ncbi.nlm.nih.gov/24260474 DMANEC9 DI DMANEC9 DMANEC9 DN Esculin DMANEC9 MI DETQXR5 DMANEC9 MN Beta-glucosidase (bglA) DMANEC9 MT DME DMANEC9 MA Metabolism DMANEC9 RN nan DMANEC9 RU nan DMANEC9 DI DMANEC9 DMANEC9 DN Esculin DMANEC9 MI DE3E0VT DMANEC9 MN L-glutamine amidohydrolase (GLS) DMANEC9 MT DME DMANEC9 MA Metabolism DMANEC9 RN KEGG: new perspectives on genomes, pathways, diseases and drugs. Nucleic Acids Res. 2017 Jan 4;45(D1):D353-D361. (cpd:C09264) DMANEC9 RU http://www.genome.jp/dbget-bin/www_bget?cpd:C09264 DMTJDXY DI DMTJDXY DMTJDXY DN ESI-09 DMTJDXY MI TTOS63B DMTJDXY MN Rap guanine nucleotide exchange factor 4 (EPAC2) DMTJDXY MT DTT DMTJDXY MA Inhibitor DMTJDXY RN A novel EPAC-specific inhibitor suppresses pancreatic cancer cell migration and invasion. Mol Pharmacol. 2013 Jan;83(1):122-8. DMTJDXY RU https://pubmed.ncbi.nlm.nih.gov/23066090 DM7K14V DI DM7K14V DM7K14V DN Estradiol 17-O-sulfamate DM7K14V MI TTHM0R1 DM7K14V MN Steryl-sulfatase (STS) DM7K14V MT DTT DM7K14V MA Inhibitor DM7K14V RN 2-substituted estradiol bis-sulfamates, multitargeted antitumor agents: synthesis, in vitro SAR, protein crystallography, and in vivo activity. J Med Chem. 2006 Dec 28;49(26):7683-96. DM7K14V RU https://pubmed.ncbi.nlm.nih.gov/17181151 DMPM8I5 DI DMPM8I5 DMPM8I5 DN Estradiol 3,17-O,O-bis-sulfamate DMPM8I5 MI TTHM0R1 DMPM8I5 MN Steryl-sulfatase (STS) DMPM8I5 MT DTT DMPM8I5 MA Inhibitor DMPM8I5 RN 2-substituted estradiol bis-sulfamates, multitargeted antitumor agents: synthesis, in vitro SAR, protein crystallography, and in vivo activity. J Med Chem. 2006 Dec 28;49(26):7683-96. DMPM8I5 RU https://pubmed.ncbi.nlm.nih.gov/17181151 DMNXO9C DI DMNXO9C DMNXO9C DN Estriol E3 DMNXO9C MI TTZAYWL DMNXO9C MN Estrogen receptor (ESR) DMNXO9C MT DTT DMNXO9C MA Modulator DMNXO9C RN Estrogen: estrone (E1), estradiol (E2), estriol (E3) and estetrol (E4). Nihon Rinsho. 2010 Jul;68 Suppl 7:448-61. DMNXO9C RU https://pubmed.ncbi.nlm.nih.gov/20960812 DMH4MBW DI DMH4MBW DMH4MBW DN ET bromodomain inhibitor DMH4MBW MI TTDP48B DMH4MBW MN Bromodomain-containing protein 2 (BRD2) DMH4MBW MT DTT DMH4MBW MA Inhibitor DMH4MBW RN Chemical biology. A bump-and-hole approach to engineer controlled selectivity of BET bromodomain chemical probes. Science. 2014 Oct 31;346(6209):638-41. DMH4MBW RU https://pubmed.ncbi.nlm.nih.gov/25323695 DM0IYLS DI DM0IYLS DM0IYLS DN EtBut-RYYRIK-NH2 DM0IYLS MI TTNT7K8 DM0IYLS MN Nociceptin receptor (OPRL1) DM0IYLS MT DTT DM0IYLS MA Inhibitor DM0IYLS RN Designed modification of partial agonist of ORL1 nociceptin receptor for conversion into highly potent antagonist. Bioorg Med Chem. 2008 Mar 1;16(5):2635-44. DM0IYLS RU https://pubmed.ncbi.nlm.nih.gov/18068993 DMMEQUR DI DMMEQUR DMMEQUR DN Ethidium DMMEQUR MI TTUTN1I DMMEQUR MN Human Deoxyribonucleic acid (hDNA) DMMEQUR MT DTT DMMEQUR MA Intercalator DMMEQUR RN 31P NMR spectra of ethidium, quinacrine, and daunomycin complexes with poly(adenylic acid).poly(uridylic acid) RNA duplex and calf thymus DNA. Biochemistry. 1989 Apr 4;28(7):2804-12. DMMEQUR RU https://pubmed.ncbi.nlm.nih.gov/2472832 DMQTEDP DI DMQTEDP DMQTEDP DN ETHIOFENCARB DMQTEDP MI TTLUQ8E DMQTEDP MN Hormone sensitive lipase (LIPE) DMQTEDP MT DTT DMQTEDP MA Inhibitor DMQTEDP RN Combining ligand-based pharmacophore modeling, quantitative structure-activity relationship analysis and in silico screening for the discovery of n... J Med Chem. 2008 Oct 23;51(20):6478-94. DMQTEDP RU https://pubmed.ncbi.nlm.nih.gov/18808096 DMGESUH DI DMGESUH DMGESUH DN ETHIONINE DMGESUH MI TTFK1JQ DMGESUH MN Voltage-gated calcium channel alpha-2/delta-1 (CACNA2D1) DMGESUH MT DTT DMGESUH MA Inhibitor DMGESUH RN Structure-activity relationships of alpha-amino acid ligands for the alpha2delta subunit of voltage-gated calcium channels. Bioorg Med Chem Lett. 2006 Mar 1;16(5):1138-41. DMGESUH RU https://pubmed.ncbi.nlm.nih.gov/16380257 DMDXRP1 DI DMDXRP1 DMDXRP1 DN ETHISTERONE DMDXRP1 MI TTULVH8 DMDXRP1 MN Tyrosinase (TYR) DMDXRP1 MT DTT DMDXRP1 MA Inhibitor DMDXRP1 RN TOMOCOMD-CARDD descriptors-based virtual screening of tyrosinase inhibitors: evaluation of different classification model combinations using bond-b... Bioorg Med Chem. 2007 Feb 1;15(3):1483-503. DMDXRP1 RU https://pubmed.ncbi.nlm.nih.gov/17110117 DM1MGTX DI DM1MGTX DM1MGTX DN ETHOXYCLUSIN DM1MGTX MI TTXV4FI DM1MGTX MN Albendazole monooxygenase (CYP3A4) DM1MGTX MT DTT DM1MGTX MA Inhibitor DM1MGTX RN Potent CYP3A4 inhibitory constituents of Piper cubeba. J Nat Prod. 2005 Jan;68(1):64-8. DM1MGTX RU https://pubmed.ncbi.nlm.nih.gov/15679319 DMSKU4M DI DMSKU4M DMSKU4M DN ETHOXYCOUMARIN DMSKU4M MI TTUNARX DMSKU4M MN Carbonic anhydrase (CA) DMSKU4M MT DTT DMSKU4M MA Inhibitor DMSKU4M RN Deciphering the mechanism of carbonic anhydrase inhibition with coumarins and thiocoumarins. J Med Chem. 2010 Jan 14;53(1):335-44. DMSKU4M RU https://pubmed.ncbi.nlm.nih.gov/19911821 DMSKU4M DI DMSKU4M DMSKU4M DN ETHOXYCOUMARIN DMSKU4M MI TT2LVK8 DMSKU4M MN Carbonic anhydrase IX (CA-IX) DMSKU4M MT DTT DMSKU4M MA Inhibitor DMSKU4M RN Deciphering the mechanism of carbonic anhydrase inhibition with coumarins and thiocoumarins. J Med Chem. 2010 Jan 14;53(1):335-44. DMSKU4M RU https://pubmed.ncbi.nlm.nih.gov/19911821 DMSKU4M DI DMSKU4M DMSKU4M DN ETHOXYCOUMARIN DMSKU4M MI TTSYM0R DMSKU4M MN Carbonic anhydrase XII (CA-XII) DMSKU4M MT DTT DMSKU4M MA Inhibitor DMSKU4M RN Deciphering the mechanism of carbonic anhydrase inhibition with coumarins and thiocoumarins. J Med Chem. 2010 Jan 14;53(1):335-44. DMSKU4M RU https://pubmed.ncbi.nlm.nih.gov/19911821 DMSKU4M DI DMSKU4M DMSKU4M DN ETHOXYCOUMARIN DMSKU4M MI TTEYTKG DMSKU4M MN Carbonic anhydrase XIV (CA-XIV) DMSKU4M MT DTT DMSKU4M MA Inhibitor DMSKU4M RN Deciphering the mechanism of carbonic anhydrase inhibition with coumarins and thiocoumarins. J Med Chem. 2010 Jan 14;53(1):335-44. DMSKU4M RU https://pubmed.ncbi.nlm.nih.gov/19911821 DMNOTH5 DI DMNOTH5 DMNOTH5 DN ETHOXY-IDAZOXAN DMNOTH5 MI TT2NUT5 DMNOTH5 MN Adrenergic receptor alpha-2C (ADRA2C) DMNOTH5 MT DTT DMNOTH5 MA Modulator DMNOTH5 RN Discriminative stimulus properties of ethoxy idazoxan. J Psychopharmacol. 1995 Jan;9(3):228-33. DMNOTH5 RU https://pubmed.ncbi.nlm.nih.gov/22297762 DM7390Y DI DM7390Y DM7390Y DN ethyketazocine DM7390Y MI TT27RFC DM7390Y MN Opioid receptor delta (OPRD1) DM7390Y MT DTT DM7390Y MA Agonist DM7390Y RN Cloning and functional comparison of kappa and delta opioid receptors from mouse brain. Proc Natl Acad Sci U S A. 1993 Jul 15;90(14):6736-40. DM7390Y RU https://pubmed.ncbi.nlm.nih.gov/8393575 DM7390Y DI DM7390Y DM7390Y DN ethyketazocine DM7390Y MI TTQW87Y DM7390Y MN Opioid receptor kappa (OPRK1) DM7390Y MT DTT DM7390Y MA Agonist DM7390Y RN Activation of the cloned human kappa opioid receptor by agonists enhances [35S]GTPgammaS binding to membranes: determination of potencies and efficacies of ligands. J Pharmacol Exp Ther. 1997 Aug;282(2):676-84. DM7390Y RU https://pubmed.ncbi.nlm.nih.gov/9262330 DM0O4A2 DI DM0O4A2 DM0O4A2 DN ETHYL (1E)-2-PHENYL-N-(SULFOOXY)ETHANIMIDOTHIOATE DM0O4A2 MI TTA0OSE DM0O4A2 MN Lactase-phlorizin hydrolase (LCT) DM0O4A2 MT DTT DM0O4A2 MA Inhibitor DM0O4A2 RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DM0O4A2 RU https://pubmed.ncbi.nlm.nih.gov/10592235 DM3FH02 DI DM3FH02 DM3FH02 DN Ethyl 1-[(1H-benzimidazol-2(3H)one-5-yl)sulfonyl]-1H-pyrrole-2-carboxylate DM3FH02 MI TTK3PY9 DM3FH02 MN DNA-dependent protein kinase catalytic (PRKDC) DM3FH02 MT DTT DM3FH02 MA Inhibitor DM3FH02 RN Discovery of potent chromen-4-one inhibitors of the DNA-dependent protein kinase (DNA-PK) using a small-molecule library approach. J Med Chem. 2005 Dec 1;48(24):7829-46. DM3FH02 RU https://pubmed.ncbi.nlm.nih.gov/16302822 DM3FH02 DI DM3FH02 DM3FH02 DN Ethyl 1-[(1H-benzimidazol-2(3H)one-5-yl)sulfonyl]-1H-pyrrole-2-carboxylate DM3FH02 MI TT84ETX DM3FH02 MN Human immunodeficiency virus Reverse transcriptase (HIV RT) DM3FH02 MT DTT DM3FH02 MA Inhibitor DM3FH02 RN Computer-assisted design, synthesis and biological evaluation of novel pyrrolyl heteroaryl sulfones targeted at HIV-1 reverse transcriptase as non-nucleoside inhibitors. Bioorg Med Chem. 2000 Sep;8(9):2305-9. DM3FH02 RU https://pubmed.ncbi.nlm.nih.gov/11026542 DM3FH02 DI DM3FH02 DM3FH02 DN Ethyl 1-[(1H-benzimidazol-2(3H)one-5-yl)sulfonyl]-1H-pyrrole-2-carboxylate DM3FH02 MI TT9H4P3 DM3FH02 MN PI3K p110 beta messenger RNA (PIK3CB mRNA) DM3FH02 MT DTT DM3FH02 MA Inhibitor DM3FH02 RN LY294002-geldanamycin heterodimers as selective inhibitors of the PI3K and PI3K-related family. Bioorg Med Chem Lett. 2001 Apr 9;11(7):909-13. DM3FH02 RU https://pubmed.ncbi.nlm.nih.gov/11294389 DM3FH02 DI DM3FH02 DM3FH02 DN Ethyl 1-[(1H-benzimidazol-2(3H)one-5-yl)sulfonyl]-1H-pyrrole-2-carboxylate DM3FH02 MI TTGBPJE DM3FH02 MN PI3-kinase delta (PIK3CD) DM3FH02 MT DTT DM3FH02 MA Inhibitor DM3FH02 RN LY294002-geldanamycin heterodimers as selective inhibitors of the PI3K and PI3K-related family. Bioorg Med Chem Lett. 2001 Apr 9;11(7):909-13. DM3FH02 RU https://pubmed.ncbi.nlm.nih.gov/11294389 DM3FH02 DI DM3FH02 DM3FH02 DN Ethyl 1-[(1H-benzimidazol-2(3H)one-5-yl)sulfonyl]-1H-pyrrole-2-carboxylate DM3FH02 MI TTHBTOP DM3FH02 MN PI3-kinase gamma (PIK3CG) DM3FH02 MT DTT DM3FH02 MA Inhibitor DM3FH02 RN LY294002-geldanamycin heterodimers as selective inhibitors of the PI3K and PI3K-related family. Bioorg Med Chem Lett. 2001 Apr 9;11(7):909-13. DM3FH02 RU https://pubmed.ncbi.nlm.nih.gov/11294389 DM3FH02 DI DM3FH02 DM3FH02 DN Ethyl 1-[(1H-benzimidazol-2(3H)one-5-yl)sulfonyl]-1H-pyrrole-2-carboxylate DM3FH02 MI TTCJG29 DM3FH02 MN Serine/threonine-protein kinase mTOR (mTOR) DM3FH02 MT DTT DM3FH02 MA Inhibitor DM3FH02 RN Selective benzopyranone and pyrimido[2,1-a]isoquinolin-4-one inhibitors of DNA-dependent protein kinase: synthesis, structure-activity studies, and... J Med Chem. 2005 Jan 27;48(2):569-85. DM3FH02 RU https://pubmed.ncbi.nlm.nih.gov/15658870 DMQ0XYH DI DMQ0XYH DMQ0XYH DN Ethyl 1-[(1H-benzimidazol-5(6)-yl)sulfonyl]-1H-pyrrole-2-carboxylate DMQ0XYH MI TT84ETX DMQ0XYH MN Human immunodeficiency virus Reverse transcriptase (HIV RT) DMQ0XYH MT DTT DMQ0XYH MA Inhibitor DMQ0XYH RN Computer-assisted design, synthesis and biological evaluation of novel pyrrolyl heteroaryl sulfones targeted at HIV-1 reverse transcriptase as non-nucleoside inhibitors. Bioorg Med Chem. 2000 Sep;8(9):2305-9. DMQ0XYH RU https://pubmed.ncbi.nlm.nih.gov/11026542 DM82X3J DI DM82X3J DM82X3J DN Ethyl 1-[(1H-benzotriazol-5(6)-yl)sulfonyl]-1H-pyrrole-2-carboxylate DM82X3J MI TT84ETX DM82X3J MN Human immunodeficiency virus Reverse transcriptase (HIV RT) DM82X3J MT DTT DM82X3J MA Inhibitor DM82X3J RN Computer-assisted design, synthesis and biological evaluation of novel pyrrolyl heteroaryl sulfones targeted at HIV-1 reverse transcriptase as non-nucleoside inhibitors. Bioorg Med Chem. 2000 Sep;8(9):2305-9. DM82X3J RU https://pubmed.ncbi.nlm.nih.gov/11026542 DM762HQ DI DM762HQ DM762HQ DN Ethyl 2-(2-oxohexadecanamido)acetate DM762HQ MI TTT1JVS DM762HQ MN Cytosolic phospholipase A2 (GIVA cPLA2) DM762HQ MT DTT DM762HQ MA Inhibitor DM762HQ RN Structure-activity relationships of natural and non-natural amino acid-based amide and 2-oxoamide inhibitors of human phospholipase A(2) enzymes. Bioorg Med Chem. 2008 Dec 15;16(24):10257-69. DM762HQ RU https://pubmed.ncbi.nlm.nih.gov/18993078 DMPUCMV DI DMPUCMV DMPUCMV DN Ethyl 2beta-hydroxyolean-12-en-28-oate DMPUCMV MI TTZHY6R DMPUCMV MN Glycogen phosphorylase muscle form (GP) DMPUCMV MT DTT DMPUCMV MA Inhibitor DMPUCMV RN Synthesis of 3-deoxypentacyclic triterpene derivatives as inhibitors of glycogen phosphorylase. J Nat Prod. 2009 Aug;72(8):1414-8. DMPUCMV RU https://pubmed.ncbi.nlm.nih.gov/19642687 DM06AQZ DI DM06AQZ DM06AQZ DN Ethyl 2-cyano-2-(quinoxalin-2(1H)-ylidene)acetate DM06AQZ MI TTHY57M DM06AQZ MN Matrix metalloproteinase-13 (MMP-13) DM06AQZ MT DTT DM06AQZ MA Inhibitor DM06AQZ RN High throughput screening of potentially selective MMP-13 exosite inhibitors utilizing a triple-helical FRET substrate. Bioorg Med Chem. 2009 Feb 1;17(3):990-1005. DM06AQZ RU https://pubmed.ncbi.nlm.nih.gov/18358729 DM5XYFN DI DM5XYFN DM5XYFN DN Ethyl 3-(biphenyl-3-ylamino)-2-cyanoacrylate DM5XYFN MI TT3PQ2Y DM5XYFN MN Plasmodium Dihydroorotate dehydrogenase (Malaria DHOdehase) DM5XYFN MT DTT DM5XYFN MA Inhibitor DM5XYFN RN Design and synthesis of potent inhibitors of the malaria parasite dihydroorotate dehydrogenase. J Med Chem. 2007 Jan 25;50(2):186-91. DM5XYFN RU https://pubmed.ncbi.nlm.nih.gov/17228860 DM4UWYF DI DM4UWYF DM4UWYF DN Ethyl 3-(pyridin-4-yl)-1H-indole-6-carboxylate DM4UWYF MI TTTB4UP DM4UWYF MN Inosine-5'-monophosphate dehydrogenase 2 (IMPDH2) DM4UWYF MT DTT DM4UWYF MA Inhibitor DM4UWYF RN Novel indole inhibitors of IMPDH from fragments: synthesis and initial structure-activity relationships. Bioorg Med Chem Lett. 2006 May 1;16(9):2539-42. DM4UWYF RU https://pubmed.ncbi.nlm.nih.gov/16483773 DMKJGLO DI DMKJGLO DMKJGLO DN ETHYL 3-[4-(AMINOSULFONYL)PHENYL]PROPANOATE DMKJGLO MI TTHQPL7 DMKJGLO MN Carbonic anhydrase I (CA-I) DMKJGLO MT DTT DMKJGLO MA Inhibitor DMKJGLO RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DMKJGLO RU https://pubmed.ncbi.nlm.nih.gov/10592235 DMKJGLO DI DMKJGLO DMKJGLO DN ETHYL 3-[4-(AMINOSULFONYL)PHENYL]PROPANOATE DMKJGLO MI TTANPDJ DMKJGLO MN Carbonic anhydrase II (CA-II) DMKJGLO MT DTT DMKJGLO MA Inhibitor DMKJGLO RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DMKJGLO RU https://pubmed.ncbi.nlm.nih.gov/10592235 DM5GLP7 DI DM5GLP7 DM5GLP7 DN Ethyl 4-(1-benzyl-1H-indazol-3-yl)benzoate DM5GLP7 MI TTD0652 DM5GLP7 MN Proteinase activated receptor 4 (F2RL3) DM5GLP7 MT DTT DM5GLP7 MA Inhibitor DM5GLP7 RN Synthesis and antiplatelet activity of ethyl 4-(1-benzyl-1H-indazol-3-yl)benzoate (YD-3) derivatives. Bioorg Med Chem. 2008 Feb 1;16(3):1262-78. DM5GLP7 RU https://pubmed.ncbi.nlm.nih.gov/17988878 DMQ3LMF DI DMQ3LMF DMQ3LMF DN Ethyl 4-(2-oxo-2H-chromene-3-carboxamido)benzoate DMQ3LMF MI TT3WG5C DMQ3LMF MN Monoamine oxidase type A (MAO-A) DMQ3LMF MT DTT DMQ3LMF MA Inhibitor DMQ3LMF RN Synthesis, molecular modeling, and selective inhibitory activity against human monoamine oxidases of 3-carboxamido-7-substituted coumarins. J Med Chem. 2009 Apr 9;52(7):1935-42. DMQ3LMF RU https://pubmed.ncbi.nlm.nih.gov/19267475 DMB12M7 DI DMB12M7 DMB12M7 DN Ethyl 4-(2-oxohexadecanamido)benzoate DMB12M7 MI TTT1JVS DMB12M7 MN Cytosolic phospholipase A2 (GIVA cPLA2) DMB12M7 MT DTT DMB12M7 MA Inhibitor DMB12M7 RN Structure-activity relationships of natural and non-natural amino acid-based amide and 2-oxoamide inhibitors of human phospholipase A(2) enzymes. Bioorg Med Chem. 2008 Dec 15;16(24):10257-69. DMB12M7 RU https://pubmed.ncbi.nlm.nih.gov/18993078 DMK4T5Y DI DMK4T5Y DMK4T5Y DN Ethyl 5-benzoyl-4-phenylthiazol-2-ylcarbamate DMK4T5Y MI TTK25J1 DMK4T5Y MN Adenosine A1 receptor (ADORA1) DMK4T5Y MT DTT DMK4T5Y MA Inhibitor DMK4T5Y RN 2-Amino-5-benzoyl-4-phenylthiazoles: Development of potent and selective adenosine A1 receptor antagonists. Bioorg Med Chem. 2010 Mar 15;18(6):2195-2203. DMK4T5Y RU https://pubmed.ncbi.nlm.nih.gov/20188574 DMK4T5Y DI DMK4T5Y DMK4T5Y DN Ethyl 5-benzoyl-4-phenylthiazol-2-ylcarbamate DMK4T5Y MI TTM2AOE DMK4T5Y MN Adenosine A2a receptor (ADORA2A) DMK4T5Y MT DTT DMK4T5Y MA Inhibitor DMK4T5Y RN 2-Amino-5-benzoyl-4-phenylthiazoles: Development of potent and selective adenosine A1 receptor antagonists. Bioorg Med Chem. 2010 Mar 15;18(6):2195-2203. DMK4T5Y RU https://pubmed.ncbi.nlm.nih.gov/20188574 DMK4T5Y DI DMK4T5Y DMK4T5Y DN Ethyl 5-benzoyl-4-phenylthiazol-2-ylcarbamate DMK4T5Y MI TTNE7KG DMK4T5Y MN Adenosine A2b receptor (ADORA2B) DMK4T5Y MT DTT DMK4T5Y MA Inhibitor DMK4T5Y RN 2-Amino-5-benzoyl-4-phenylthiazoles: Development of potent and selective adenosine A1 receptor antagonists. Bioorg Med Chem. 2010 Mar 15;18(6):2195-2203. DMK4T5Y RU https://pubmed.ncbi.nlm.nih.gov/20188574 DMK4T5Y DI DMK4T5Y DMK4T5Y DN Ethyl 5-benzoyl-4-phenylthiazol-2-ylcarbamate DMK4T5Y MI TTJFY5U DMK4T5Y MN Adenosine A3 receptor (ADORA3) DMK4T5Y MT DTT DMK4T5Y MA Inhibitor DMK4T5Y RN 2-Amino-5-benzoyl-4-phenylthiazoles: Development of potent and selective adenosine A1 receptor antagonists. Bioorg Med Chem. 2010 Mar 15;18(6):2195-2203. DMK4T5Y RU https://pubmed.ncbi.nlm.nih.gov/20188574 DM5G91Z DI DM5G91Z DM5G91Z DN Ethyl 6-iodo-9H-pyrido[3,4-b]indole-3-carboxylate DM5G91Z MI TT1MPAY DM5G91Z MN GABA(A) receptor alpha-1 (GABRA1) DM5G91Z MT DTT DM5G91Z MA Inhibitor DM5G91Z RN Design, synthesis, and subtype selectivity of 3,6-disubstituted -carbolines at Bz/GABA(A)ergic receptors. SAR and studies directed toward agents f... Bioorg Med Chem. 2010 Nov 1;18(21):7548-64. DM5G91Z RU https://pubmed.ncbi.nlm.nih.gov/20888240 DM5G91Z DI DM5G91Z DM5G91Z DN Ethyl 6-iodo-9H-pyrido[3,4-b]indole-3-carboxylate DM5G91Z MI TTBMV1G DM5G91Z MN GABA(A) receptor alpha-2 (GABRA2) DM5G91Z MT DTT DM5G91Z MA Inhibitor DM5G91Z RN Design, synthesis, and subtype selectivity of 3,6-disubstituted -carbolines at Bz/GABA(A)ergic receptors. SAR and studies directed toward agents f... Bioorg Med Chem. 2010 Nov 1;18(21):7548-64. DM5G91Z RU https://pubmed.ncbi.nlm.nih.gov/20888240 DM5G91Z DI DM5G91Z DM5G91Z DN Ethyl 6-iodo-9H-pyrido[3,4-b]indole-3-carboxylate DM5G91Z MI TT37EDJ DM5G91Z MN GABA(A) receptor alpha-3 (GABRA3) DM5G91Z MT DTT DM5G91Z MA Inhibitor DM5G91Z RN Design, synthesis, and subtype selectivity of 3,6-disubstituted -carbolines at Bz/GABA(A)ergic receptors. SAR and studies directed toward agents f... Bioorg Med Chem. 2010 Nov 1;18(21):7548-64. DM5G91Z RU https://pubmed.ncbi.nlm.nih.gov/20888240 DM5G91Z DI DM5G91Z DM5G91Z DN Ethyl 6-iodo-9H-pyrido[3,4-b]indole-3-carboxylate DM5G91Z MI TTNZPQ1 DM5G91Z MN GABA(A) receptor alpha-5 (GABRA5) DM5G91Z MT DTT DM5G91Z MA Inhibitor DM5G91Z RN Design, synthesis, and subtype selectivity of 3,6-disubstituted -carbolines at Bz/GABA(A)ergic receptors. SAR and studies directed toward agents f... Bioorg Med Chem. 2010 Nov 1;18(21):7548-64. DM5G91Z RU https://pubmed.ncbi.nlm.nih.gov/20888240 DM5G91Z DI DM5G91Z DM5G91Z DN Ethyl 6-iodo-9H-pyrido[3,4-b]indole-3-carboxylate DM5G91Z MI TT06RH5 DM5G91Z MN GABA(A) receptor gamma-2 (GABRG2) DM5G91Z MT DTT DM5G91Z MA Inhibitor DM5G91Z RN Design, synthesis, and subtype selectivity of 3,6-disubstituted -carbolines at Bz/GABA(A)ergic receptors. SAR and studies directed toward agents f... Bioorg Med Chem. 2010 Nov 1;18(21):7548-64. DM5G91Z RU https://pubmed.ncbi.nlm.nih.gov/20888240 DM5G91Z DI DM5G91Z DM5G91Z DN Ethyl 6-iodo-9H-pyrido[3,4-b]indole-3-carboxylate DM5G91Z MI TTNJYV2 DM5G91Z MN Gamma-aminobutyric acid receptor (GAR) DM5G91Z MT DTT DM5G91Z MA Inhibitor DM5G91Z RN Design, synthesis, and subtype selectivity of 3,6-disubstituted -carbolines at Bz/GABA(A)ergic receptors. SAR and studies directed toward agents f... Bioorg Med Chem. 2010 Nov 1;18(21):7548-64. DM5G91Z RU https://pubmed.ncbi.nlm.nih.gov/20888240 DM7FPX8 DI DM7FPX8 DM7FPX8 DN Ethyl 7-hydroxy-2-oxo-2H-chromene-3-carboxylate DM7FPX8 MI TT6804T DM7FPX8 MN MIF messenger RNA (MIF mRNA) DM7FPX8 MT DTT DM7FPX8 MA Inhibitor DM7FPX8 RN Discovery of human macrophage migration inhibitory factor (MIF)-CD74 antagonists via virtual screening. J Med Chem. 2009 Jan 22;52(2):416-24. DM7FPX8 RU https://pubmed.ncbi.nlm.nih.gov/19090668 DMWIB0V DI DMWIB0V DMWIB0V DN Ethyl 7-methoxy-2-oxo-2H-chromene-3-carboxylate DMWIB0V MI TTUNARX DMWIB0V MN Carbonic anhydrase (CA) DMWIB0V MT DTT DMWIB0V MA Inhibitor DMWIB0V RN Deciphering the mechanism of carbonic anhydrase inhibition with coumarins and thiocoumarins. J Med Chem. 2010 Jan 14;53(1):335-44. DMWIB0V RU https://pubmed.ncbi.nlm.nih.gov/19911821 DMWIB0V DI DMWIB0V DMWIB0V DN Ethyl 7-methoxy-2-oxo-2H-chromene-3-carboxylate DMWIB0V MI TTZHA0O DMWIB0V MN Carbonic anhydrase IV (CA-IV) DMWIB0V MT DTT DMWIB0V MA Inhibitor DMWIB0V RN Deciphering the mechanism of carbonic anhydrase inhibition with coumarins and thiocoumarins. J Med Chem. 2010 Jan 14;53(1):335-44. DMWIB0V RU https://pubmed.ncbi.nlm.nih.gov/19911821 DMWIB0V DI DMWIB0V DMWIB0V DN Ethyl 7-methoxy-2-oxo-2H-chromene-3-carboxylate DMWIB0V MI TT2LVK8 DMWIB0V MN Carbonic anhydrase IX (CA-IX) DMWIB0V MT DTT DMWIB0V MA Inhibitor DMWIB0V RN Deciphering the mechanism of carbonic anhydrase inhibition with coumarins and thiocoumarins. J Med Chem. 2010 Jan 14;53(1):335-44. DMWIB0V RU https://pubmed.ncbi.nlm.nih.gov/19911821 DMWIB0V DI DMWIB0V DMWIB0V DN Ethyl 7-methoxy-2-oxo-2H-chromene-3-carboxylate DMWIB0V MI TTCFSPE DMWIB0V MN Carbonic anhydrase VI (CA-VI) DMWIB0V MT DTT DMWIB0V MA Inhibitor DMWIB0V RN Deciphering the mechanism of carbonic anhydrase inhibition with coumarins and thiocoumarins. J Med Chem. 2010 Jan 14;53(1):335-44. DMWIB0V RU https://pubmed.ncbi.nlm.nih.gov/19911821 DMWIB0V DI DMWIB0V DMWIB0V DN Ethyl 7-methoxy-2-oxo-2H-chromene-3-carboxylate DMWIB0V MI TTSYM0R DMWIB0V MN Carbonic anhydrase XII (CA-XII) DMWIB0V MT DTT DMWIB0V MA Inhibitor DMWIB0V RN Deciphering the mechanism of carbonic anhydrase inhibition with coumarins and thiocoumarins. J Med Chem. 2010 Jan 14;53(1):335-44. DMWIB0V RU https://pubmed.ncbi.nlm.nih.gov/19911821 DMWIB0V DI DMWIB0V DMWIB0V DN Ethyl 7-methoxy-2-oxo-2H-chromene-3-carboxylate DMWIB0V MI TTEYTKG DMWIB0V MN Carbonic anhydrase XIV (CA-XIV) DMWIB0V MT DTT DMWIB0V MA Inhibitor DMWIB0V RN Deciphering the mechanism of carbonic anhydrase inhibition with coumarins and thiocoumarins. J Med Chem. 2010 Jan 14;53(1):335-44. DMWIB0V RU https://pubmed.ncbi.nlm.nih.gov/19911821 DMJQTIK DI DMJQTIK DMJQTIK DN Ethyl Bis(4-hydroxy-2-oxo-2H-chromen-3-yl)acetate DMJQTIK MI TT8XK6L DMJQTIK MN Quinone reductase 1 (NQO1) DMJQTIK MT DTT DMJQTIK MA Inhibitor DMJQTIK RN Synthesis and biological evaluation of coumarin-based inhibitors of NAD(P)H: quinone oxidoreductase-1 (NQO1). J Med Chem. 2009 Nov 26;52(22):7142-56. DMJQTIK RU https://pubmed.ncbi.nlm.nih.gov/19877692 DMR5Z2A DI DMR5Z2A DMR5Z2A DN Ethyl biscoumacetate DMR5Z2A MI DE4LYSA DMR5Z2A MN Cytochrome P450 3A4 (CYP3A4) DMR5Z2A MT DME DMR5Z2A MA Metabolism DMR5Z2A RN Diet Drug Porfimer sodium Safe, Effective, Study Finds. DMR5Z2A RU http://pastande.org/diet-drug-porfimer-sodium-safe-effective-study-finds/ DMW0J3D DI DMW0J3D DMW0J3D DN Ethyl Dihydrogen Phosphate DMW0J3D MI TTEB0GD DMW0J3D MN Cholinesterase (BCHE) DMW0J3D MT DTT DMW0J3D MA Inhibitor DMW0J3D RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMW0J3D RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMXTLJE DI DMXTLJE DMXTLJE DN Ethyl estrone-16-methylcarboxylate DMXTLJE MI TTIWB6L DMXTLJE MN Estradiol 17 beta-dehydrogenase 1 (17-beta-HSD1) DMXTLJE MT DTT DMXTLJE MA Inhibitor DMXTLJE RN Modification of estrone at the 6, 16, and 17 positions: novel potent inhibitors of 17beta-hydroxysteroid dehydrogenase type 1. J Med Chem. 2006 Feb 23;49(4):1325-45. DMXTLJE RU https://pubmed.ncbi.nlm.nih.gov/16480268 DMT4XJM DI DMT4XJM DMT4XJM DN ETHYL HYDROGEN DIETHYLAMIDOPHOSPHATE DMT4XJM MI TTEB0GD DMT4XJM MN Cholinesterase (BCHE) DMT4XJM MT DTT DMT4XJM MA Inhibitor DMT4XJM RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DMT4XJM RU https://pubmed.ncbi.nlm.nih.gov/10592235 DMXMRK7 DI DMXMRK7 DMXMRK7 DN Ethyl octylfluorophosphonate DMXMRK7 MI TT1RS9F DMXMRK7 MN Acetylcholinesterase (AChE) DMXMRK7 MT DTT DMXMRK7 MA Inhibitor DMXMRK7 RN Activation of the endocannabinoid system by organophosphorus nerve agents. Nat Chem Biol. 2008 Jun;4(6):373-8. DMXMRK7 RU https://pubmed.ncbi.nlm.nih.gov/18438404 DMXMRK7 DI DMXMRK7 DMXMRK7 DN Ethyl octylfluorophosphonate DMXMRK7 MI TTDP1UC DMXMRK7 MN Fatty acid amide hydrolase (FAAH) DMXMRK7 MT DTT DMXMRK7 MA Inhibitor DMXMRK7 RN Activation of the endocannabinoid system by organophosphorus nerve agents. Nat Chem Biol. 2008 Jun;4(6):373-8. DMXMRK7 RU https://pubmed.ncbi.nlm.nih.gov/18438404 DM9KF0H DI DM9KF0H DM9KF0H DN Ethyl Oxo(Piperidin-1-Yl)Acetate DM9KF0H MI TTL2ADK DM9KF0H MN Rotamase A (PPIA) DM9KF0H MT DTT DM9KF0H MA Inhibitor DM9KF0H RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DM9KF0H RU https://pubmed.ncbi.nlm.nih.gov/10592235 DMYFK4L DI DMYFK4L DMYFK4L DN Ethyl-(4,5,6,7-tetrahydro-2H-indazol-5-yl)-amine DMYFK4L MI TTEX248 DMYFK4L MN Dopamine D2 receptor (D2R) DMYFK4L MT DTT DMYFK4L MA Inhibitor DMYFK4L RN Substituted 5-amino-4,5,6,7-tetrahydroindazoles as partial ergoline structures with dopaminergic activity. J Med Chem. 1989 Oct;32(10):2388-96. DMYFK4L RU https://pubmed.ncbi.nlm.nih.gov/2571732 DMBULX4 DI DMBULX4 DMBULX4 DN Ethylene diamine DMBULX4 MI TT4ILYC DMBULX4 MN Bacterial Dihydropteroate synthetase (Bact folP) DMBULX4 MT DTT DMBULX4 MA Inhibitor DMBULX4 RN Novel agents in the management of Mycobacterium tuberculosis disease. Curr Med Chem. 2007;14(18):2000-8. DMBULX4 RU https://pubmed.ncbi.nlm.nih.gov/17691942 DMBULX4 DI DMBULX4 DMBULX4 DN Ethylene diamine DMBULX4 MI DEMWO83 DMBULX4 MN Putrescine acetyltransferase (SSAT1) DMBULX4 MT DME DMBULX4 MA Metabolism DMBULX4 RN Mechanistic and structural analysis of human spermidine/spermine N1-acetyltransferase. Biochemistry. 2007 Jun 19;46(24):7187-95. DMBULX4 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=17516632 DMJ6PB8 DI DMJ6PB8 DMJ6PB8 DN Ethylgallate DMJ6PB8 MI DEWRN24 DMJ6PB8 MN Glucansucrase (gtf106B) DMJ6PB8 MT DME DMJ6PB8 MA Metabolism DMJ6PB8 RN Exploring the effects of plant odors, from tree species of differing host quality, on the response of Lymantria dispar males to female sex pheromones. J Chem Ecol. 2017 Mar;43(3):243-253. DMJ6PB8 RU https://pubmed.ncbi.nlm.nih.gov/28258317 DMJ6PB8 DI DMJ6PB8 DMJ6PB8 DN Ethylgallate DMJ6PB8 MI TTE14XG DMJ6PB8 MN Squalene monooxygenase (SQLE) DMJ6PB8 MT DTT DMJ6PB8 MA Inhibitor DMJ6PB8 RN Ellagitannins and hexahydroxydiphenoyl esters as inhibitors of vertebrate squalene epoxidase. J Nat Prod. 2001 Aug;64(8):1010-4. DMJ6PB8 RU https://pubmed.ncbi.nlm.nih.gov/11520216 DM3CWFR DI DM3CWFR DM3CWFR DN Ethyl-indol-1-yl-pyridin-4-yl-amine DM3CWFR MI TTWG9A4 DM3CWFR MN Adrenergic receptor alpha-2A (ADRA2A) DM3CWFR MT DTT DM3CWFR MA Inhibitor DM3CWFR RN Synthesis and structure-activity relationships of N-propyl-N-(4-pyridinyl)-1H-indol-1-amine (besipirdine) and related analogs as potential therapeu... J Med Chem. 1996 Jan 19;39(2):570-81. DM3CWFR RU https://pubmed.ncbi.nlm.nih.gov/8558529 DM3CWFR DI DM3CWFR DM3CWFR DN Ethyl-indol-1-yl-pyridin-4-yl-amine DM3CWFR MI TTWM4TY DM3CWFR MN Adrenergic receptor alpha-2B (ADRA2B) DM3CWFR MT DTT DM3CWFR MA Inhibitor DM3CWFR RN Synthesis and structure-activity relationships of N-propyl-N-(4-pyridinyl)-1H-indol-1-amine (besipirdine) and related analogs as potential therapeu... J Med Chem. 1996 Jan 19;39(2):570-81. DM3CWFR RU https://pubmed.ncbi.nlm.nih.gov/8558529 DM3CWFR DI DM3CWFR DM3CWFR DN Ethyl-indol-1-yl-pyridin-4-yl-amine DM3CWFR MI TT2NUT5 DM3CWFR MN Adrenergic receptor alpha-2C (ADRA2C) DM3CWFR MT DTT DM3CWFR MA Inhibitor DM3CWFR RN Synthesis and structure-activity relationships of N-propyl-N-(4-pyridinyl)-1H-indol-1-amine (besipirdine) and related analogs as potential therapeu... J Med Chem. 1996 Jan 19;39(2):570-81. DM3CWFR RU https://pubmed.ncbi.nlm.nih.gov/8558529 DMV9OCU DI DMV9OCU DMV9OCU DN Ethylisothiourea DMV9OCU MI TTCM4B3 DMV9OCU MN Nitric-oxide synthase endothelial (NOS3) DMV9OCU MT DTT DMV9OCU MA Inhibitor DMV9OCU RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMV9OCU RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMV9OCU DI DMV9OCU DMV9OCU DN Ethylisothiourea DMV9OCU MI TTF10I9 DMV9OCU MN Nitric-oxide synthase inducible (NOS2) DMV9OCU MT DTT DMV9OCU MA Inhibitor DMV9OCU RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMV9OCU RU https://pubmed.ncbi.nlm.nih.gov/17139284 DM9YRCU DI DM9YRCU DM9YRCU DN ethylketocyclazocine DM9YRCU MI TT27RFC DM9YRCU MN Opioid receptor delta (OPRD1) DM9YRCU MT DTT DM9YRCU MA Agonist DM9YRCU RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 317). DM9YRCU RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=317 DM9YRCU DI DM9YRCU DM9YRCU DN ethylketocyclazocine DM9YRCU MI TTQW87Y DM9YRCU MN Opioid receptor kappa (OPRK1) DM9YRCU MT DTT DM9YRCU MA Agonist DM9YRCU RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 318). DM9YRCU RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=318 DM9YRCU DI DM9YRCU DM9YRCU DN ethylketocyclazocine DM9YRCU MI TTKWM86 DM9YRCU MN Opioid receptor mu (MOP) DM9YRCU MT DTT DM9YRCU MA Agonist DM9YRCU RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 319). DM9YRCU RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=319 DM0YROF DI DM0YROF DM0YROF DN Ethylmorphine DM0YROF MI DEPKLMQ DM0YROF MN Cytochrome P450 2B6 (CYP2B6) DM0YROF MT DME DM0YROF MA Metabolism DM0YROF RN Inhibitory monoclonal antibody to human cytochrome P450 2B6. Biochem Pharmacol. 1998 May 15;55(10):1633-40. DM0YROF RU https://www.ncbi.nlm.nih.gov/pubmed/?term=9633999 DM0YROF DI DM0YROF DM0YROF DN Ethylmorphine DM0YROF MI DECB0K3 DM0YROF MN Cytochrome P450 2D6 (CYP2D6) DM0YROF MT DME DM0YROF MA Metabolism DM0YROF RN A sensitive LC-MS/MS assay for the determination of dextromethorphan and metabolites in human urine--application for drug interaction studies assessing potential CYP3A and CYP2D6 inhibition. J Pharm Biomed Anal. 2002 Aug 22;30(1):113-24. DM0YROF RU https://www.ncbi.nlm.nih.gov/pubmed/?term=12151071 DM0YROF DI DM0YROF DM0YROF DN Ethylmorphine DM0YROF MI DE4LYSA DM0YROF MN Cytochrome P450 3A4 (CYP3A4) DM0YROF MT DME DM0YROF MA Metabolism DM0YROF RN Metabolic activation of aromatic amines by human pancreas. Carcinogenesis. 1997 May;18(5):1085-92. DM0YROF RU https://www.ncbi.nlm.nih.gov/pubmed/?term=9163700 DM0YROF DI DM0YROF DM0YROF DN Ethylmorphine DM0YROF MI DERD86B DM0YROF MN Cytochrome P450 3A7 (CYP3A7) DM0YROF MT DME DM0YROF MA Metabolism DM0YROF RN Summary of information on human CYP enzymes: human P450 metabolism data. Drug Metab Rev. 2002 Feb-May;34(1-2):83-448. DM0YROF RU https://www.ncbi.nlm.nih.gov/pubmed/?term=11996015 DM0YROF DI DM0YROF DM0YROF DN Ethylmorphine DM0YROF MI DEIZLTN DM0YROF MN Docosahexaenoic acid omega-hydroxylase (CYP4F11) DM0YROF MT DME DM0YROF MA Metabolism DM0YROF RN Expression and characterization of human cytochrome P450 4F11: putative role in the metabolism of therapeutic drugs and eicosanoids. Toxicol Appl Pharmacol. 2004 Sep 15;199(3):295-304. DM0YROF RU https://pubmed.ncbi.nlm.nih.gov/15364545 DM0YROF DI DM0YROF DM0YROF DN Ethylmorphine DM0YROF MI TTKWM86 DM0YROF MN Opioid receptor mu (MOP) DM0YROF MT DTT DM0YROF MA Agonist DM0YROF RN Biotransformation and pharmacokinetics of ethylmorphine after a single oral dose. Br J Clin Pharmacol. 1995 Jun;39(6):611-20. DM0YROF RU https://pubmed.ncbi.nlm.nih.gov/7654478 DMT51QD DI DMT51QD DMT51QD DN ETHYLPHENSERINE DMT51QD MI TT1RS9F DMT51QD MN Acetylcholinesterase (AChE) DMT51QD MT DTT DMT51QD MA Inhibitor DMT51QD RN Novel carbamates as orally active acetylcholinesterase inhibitors found to improve scopolamine-induced cognition impairment: pharmacophore-based vi... J Med Chem. 2010 Sep 9;53(17):6490-505. DMT51QD RU https://pubmed.ncbi.nlm.nih.gov/20684567 DM4FW3H DI DM4FW3H DM4FW3H DN ETICLOPRIDE DM4FW3H MI TTEX248 DM4FW3H MN Dopamine D2 receptor (D2R) DM4FW3H MT DTT DM4FW3H MA Inhibitor DM4FW3H RN Potential antipsychotic agents 5. Synthesis and antidopaminergic properties of substituted 5,6-dimethoxysalicylamides and related compounds. J Med Chem. 1990 Apr;33(4):1155-63. DM4FW3H RU https://pubmed.ncbi.nlm.nih.gov/1969484 DMR9YL6 DI DMR9YL6 DMR9YL6 DN Etilamfetamine DMR9YL6 MI DECB0K3 DMR9YL6 MN Cytochrome P450 2D6 (CYP2D6) DMR9YL6 MT DME DMR9YL6 MA Metabolism DMR9YL6 RN Involvement of CYP2D6 in the in vitro metabolism of amphetamine, two N-alkylamphetamines and their 4-methoxylated derivatives. Xenobiotica. 1999 Jul;29(7):719-32. DMR9YL6 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=10456690 DMVI9DM DI DMVI9DM DMVI9DM DN ETIOCHOLANOLONE DMVI9DM MI TTNJYV2 DMVI9DM MN Gamma-aminobutyric acid receptor (GAR) DMVI9DM MT DTT DMVI9DM MA Inhibitor DMVI9DM RN Neurosteroid analogues. 11. Alternative ring system scaffolds: gamma-aminobutyric acid receptor modulation and anesthetic actions of benz[f]indenes. J Med Chem. 2006 Jul 27;49(15):4595-605. DMVI9DM RU https://pubmed.ncbi.nlm.nih.gov/16854065 DMKH8TC DI DMKH8TC DMKH8TC DN Etisulergine DMKH8TC MI TTSQIFT DMKH8TC MN 5-HT 1A receptor (HTR1A) DMKH8TC MT DTT DMKH8TC MA Inhibitor DMKH8TC RN Resolution and absolute configuration of the potent dopamine agonist N,N-diethyl-N'-[(3 alpha, 4a alpha, 10a beta)-1,2,3,4,4a,5,10,10a- -octahydro-... J Med Chem. 1985 Oct;28(10):1540-2. DMKH8TC RU https://pubmed.ncbi.nlm.nih.gov/4045929 DMKH8TC DI DMKH8TC DMKH8TC DN Etisulergine DMKH8TC MI TT6MSOK DMKH8TC MN 5-HT 1D receptor (HTR1D) DMKH8TC MT DTT DMKH8TC MA Inhibitor DMKH8TC RN Resolution and absolute configuration of the potent dopamine agonist N,N-diethyl-N'-[(3 alpha, 4a alpha, 10a beta)-1,2,3,4,4a,5,10,10a- -octahydro-... J Med Chem. 1985 Oct;28(10):1540-2. DMKH8TC RU https://pubmed.ncbi.nlm.nih.gov/4045929 DMKH8TC DI DMKH8TC DMKH8TC DN Etisulergine DMKH8TC MI TTJQOD7 DMKH8TC MN 5-HT 2A receptor (HTR2A) DMKH8TC MT DTT DMKH8TC MA Inhibitor DMKH8TC RN Resolution and absolute configuration of the potent dopamine agonist N,N-diethyl-N'-[(3 alpha, 4a alpha, 10a beta)-1,2,3,4,4a,5,10,10a- -octahydro-... J Med Chem. 1985 Oct;28(10):1540-2. DMKH8TC RU https://pubmed.ncbi.nlm.nih.gov/4045929 DMDOX1Z DI DMDOX1Z DMDOX1Z DN Etoloxamine DMDOX1Z MI TTZFYLI DMDOX1Z MN Dopamine D1 receptor (D1R) DMDOX1Z MT DTT DMDOX1Z MA Inhibitor DMDOX1Z RN Dopamine/serotonin receptor ligands. 9. Oxygen-containing midsized heterocyclic ring systems and nonrigidized analogues. A step toward dopamine D5 ... J Med Chem. 2004 Aug 12;47(17):4155-8. DMDOX1Z RU https://pubmed.ncbi.nlm.nih.gov/15293986 DMDOX1Z DI DMDOX1Z DMDOX1Z DN Etoloxamine DMDOX1Z MI TTEX248 DMDOX1Z MN Dopamine D2 receptor (D2R) DMDOX1Z MT DTT DMDOX1Z MA Inhibitor DMDOX1Z RN Dopamine/serotonin receptor ligands. 9. Oxygen-containing midsized heterocyclic ring systems and nonrigidized analogues. A step toward dopamine D5 ... J Med Chem. 2004 Aug 12;47(17):4155-8. DMDOX1Z RU https://pubmed.ncbi.nlm.nih.gov/15293986 DMDOX1Z DI DMDOX1Z DMDOX1Z DN Etoloxamine DMDOX1Z MI TT4C8EA DMDOX1Z MN Dopamine D3 receptor (D3R) DMDOX1Z MT DTT DMDOX1Z MA Inhibitor DMDOX1Z RN Dopamine/serotonin receptor ligands. 9. Oxygen-containing midsized heterocyclic ring systems and nonrigidized analogues. A step toward dopamine D5 ... J Med Chem. 2004 Aug 12;47(17):4155-8. DMDOX1Z RU https://pubmed.ncbi.nlm.nih.gov/15293986 DMFR1SE DI DMFR1SE DMFR1SE DN ETONITAZENE DMFR1SE MI TT27RFC DMFR1SE MN Opioid receptor delta (OPRD1) DMFR1SE MT DTT DMFR1SE MA Inhibitor DMFR1SE RN Photoactivatable opiate derivatives as irreversible probes of the mu-opioid receptor. J Med Chem. 1990 Sep;33(9):2456-64. DMFR1SE RU https://pubmed.ncbi.nlm.nih.gov/2167979 DMFR1SE DI DMFR1SE DMFR1SE DN ETONITAZENE DMFR1SE MI TTQW87Y DMFR1SE MN Opioid receptor kappa (OPRK1) DMFR1SE MT DTT DMFR1SE MA Inhibitor DMFR1SE RN Photoactivatable opiate derivatives as irreversible probes of the mu-opioid receptor. J Med Chem. 1990 Sep;33(9):2456-64. DMFR1SE RU https://pubmed.ncbi.nlm.nih.gov/2167979 DMFR1SE DI DMFR1SE DMFR1SE DN ETONITAZENE DMFR1SE MI TTKWM86 DMFR1SE MN Opioid receptor mu (MOP) DMFR1SE MT DTT DMFR1SE MA Inhibitor DMFR1SE RN Ligand binding to nucleic acids and proteins: Does selectivity increase with strength Eur J Med Chem. 2008 Nov;43(11):2307-15. DMFR1SE RU https://pubmed.ncbi.nlm.nih.gov/18403056 DM79YZN DI DM79YZN DM79YZN DN Etorphine DM79YZN MI TT27RFC DM79YZN MN Opioid receptor delta (OPRD1) DM79YZN MT DTT DM79YZN MA Agonist DM79YZN RN Agonist-, antagonist-, and inverse agonist-regulated trafficking of the delta-opioid receptor correlates with, but does not require, G protein activation. J Pharmacol Exp Ther. 2001 Sep;298(3):1015-20. DM79YZN RU https://pubmed.ncbi.nlm.nih.gov/11504798 DM79YZN DI DM79YZN DM79YZN DN Etorphine DM79YZN MI TTKWM86 DM79YZN MN Opioid receptor mu (MOP) DM79YZN MT DTT DM79YZN MA Agonist DM79YZN RN Internalization of mu-opioid receptors produced by etorphine in the rat locus coeruleus. Neuroscience. 2001;108(3):467-77. DM79YZN RU https://pubmed.ncbi.nlm.nih.gov/11738260 DM79XSF DI DM79XSF DM79XSF DN ETP-45658 DM79XSF MI TTWR6YK DM79XSF MN PI3-kinase (PIK3C) DM79XSF MT DTT DM79XSF MA Inhibitor DM79XSF RN A novel phosphatidylinositol 3-kinase (PI3K) inhibitor directs a potent FOXO-dependent, p53-independent cell cycle arrest phenotype characterized by the differential induction of a subset of FOXO-regulated genes. Breast Cancer Res. 2014 Dec 9;16(6):482. DM79XSF RU https://pubmed.ncbi.nlm.nih.gov/25488803 DMO2PY8 DI DMO2PY8 DMO2PY8 DN ETP-46321 DMO2PY8 MI TTEUNMR DMO2PY8 MN PI3-kinase alpha (PIK3CA) DMO2PY8 MT DTT DMO2PY8 MA Inhibitor DMO2PY8 RN ETP-46321, a dual p110alpha/ class IA phosphoinositide 3-kinase inhibitor modulates T lymphocyte activation and collagen-induced arthritis. Biochem Pharmacol. 2016 Apr 15;106:56-69. DMO2PY8 RU https://pubmed.ncbi.nlm.nih.gov/26883061 DMO2PY8 DI DMO2PY8 DMO2PY8 DN ETP-46321 DMO2PY8 MI TTGBPJE DMO2PY8 MN PI3-kinase delta (PIK3CD) DMO2PY8 MT DTT DMO2PY8 MA Inhibitor DMO2PY8 RN ETP-46321, a dual p110alpha/ class IA phosphoinositide 3-kinase inhibitor modulates T lymphocyte activation and collagen-induced arthritis. Biochem Pharmacol. 2016 Apr 15;106:56-69. DMO2PY8 RU https://pubmed.ncbi.nlm.nih.gov/26883061 DMZ1FCJ DI DMZ1FCJ DMZ1FCJ DN EU-517 DMZ1FCJ MI TTL53M6 DMZ1FCJ MN Induced myeloid leukemia cell differentiation protein Mcl-1 (MCL1) DMZ1FCJ MT DTT DMZ1FCJ MA Inhibitor DMZ1FCJ RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2847). DMZ1FCJ RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2847 DMR3487 DI DMR3487 DMR3487 DN EU-C-001 DMR3487 MI TTZPO1L DMR3487 MN Substance-P receptor (TACR1) DMR3487 MT DTT DMR3487 MA Modulator DMR3487 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 360). DMR3487 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=360 DME5CK3 DI DME5CK3 DME5CK3 DN eucalyptol DME5CK3 MI TTXDKTO DME5CK3 MN Long transient receptor potential channel 8 (TRPM8) DME5CK3 MT DTT DME5CK3 MA Activator DME5CK3 RN Identification of a cold receptor reveals a general role for TRP channels in thermosensation. Nature. 2002 Mar 7;416(6876):52-8. DME5CK3 RU https://pubmed.ncbi.nlm.nih.gov/11882888 DMUA485 DI DMUA485 DMUA485 DN EUGENIIN DMUA485 MI TTE14XG DMUA485 MN Squalene monooxygenase (SQLE) DMUA485 MT DTT DMUA485 MA Inhibitor DMUA485 RN Ellagitannins and hexahydroxydiphenoyl esters as inhibitors of vertebrate squalene epoxidase. J Nat Prod. 2001 Aug;64(8):1010-4. DMUA485 RU https://pubmed.ncbi.nlm.nih.gov/11520216 DMLXKZH DI DMLXKZH DMLXKZH DN EUPAFOLIN DMLXKZH MI TT86VZE DMLXKZH MN Plasmodium M1-family aminopeptidase (Malaria MFA) DMLXKZH MT DTT DMLXKZH MA Inhibitor DMLXKZH RN In silico identification and biochemical evaluation of novel inhibitors of NRH:quinone oxidoreductase 2 (NQO2). Bioorg Med Chem Lett. 2010 Dec 15;20(24):7331-6. DMLXKZH RU https://pubmed.ncbi.nlm.nih.gov/21074425 DM068CY DI DM068CY DM068CY DN EUPATORIOPICRIN DM068CY MI TTICX3S DM068CY MN Bacterial UDP-N-acetylglucosamine carboxyvinyltransferase (Bact murA) DM068CY MT DTT DM068CY MA Inhibitor DM068CY RN Sesquiterpene lactones are potent and irreversible inhibitors of the antibacterial target enzyme MurA. Bioorg Med Chem Lett. 2006 Nov 1;16(21):5605-9. DM068CY RU https://pubmed.ncbi.nlm.nih.gov/16945528 DMO3AZ6 DI DMO3AZ6 DMO3AZ6 DN Euro-Celtique 1 DMO3AZ6 MI TTXHYV6 DMO3AZ6 MN Voltage-gated L-type calcium channel (L-CaC) DMO3AZ6 MT DTT DMO3AZ6 MA Blocker DMO3AZ6 RN Recent updates of N-type calcium channel blockers with therapeutic potential for neuropathic pain and stroke. Curr Top Med Chem. 2009;9(4):377-95. DMO3AZ6 RU https://pubmed.ncbi.nlm.nih.gov/19442208 DMJH4BF DI DMJH4BF DMJH4BF DN Euro-Celtique 2 DMJH4BF MI TTXHYV6 DMJH4BF MN Voltage-gated L-type calcium channel (L-CaC) DMJH4BF MT DTT DMJH4BF MA Blocker DMJH4BF RN Recent updates of N-type calcium channel blockers with therapeutic potential for neuropathic pain and stroke. Curr Top Med Chem. 2009;9(4):377-95. DMJH4BF RU https://pubmed.ncbi.nlm.nih.gov/19442208 DM8VI3T DI DM8VI3T DM8VI3T DN Euro-Celtique 3 DM8VI3T MI TTXHYV6 DM8VI3T MN Voltage-gated L-type calcium channel (L-CaC) DM8VI3T MT DTT DM8VI3T MA Blocker DM8VI3T RN Recent updates of N-type calcium channel blockers with therapeutic potential for neuropathic pain and stroke. Curr Top Med Chem. 2009;9(4):377-95. DM8VI3T RU https://pubmed.ncbi.nlm.nih.gov/19442208 DMO4CEL DI DMO4CEL DMO4CEL DN Euro-Celtique 4 DMO4CEL MI TTXHYV6 DMO4CEL MN Voltage-gated L-type calcium channel (L-CaC) DMO4CEL MT DTT DMO4CEL MA Blocker DMO4CEL RN Recent updates of N-type calcium channel blockers with therapeutic potential for neuropathic pain and stroke. Curr Top Med Chem. 2009;9(4):377-95. DMO4CEL RU https://pubmed.ncbi.nlm.nih.gov/19442208 DMXBGSL DI DMXBGSL DMXBGSL DN EUSYNSTYELAMIDE B DMXBGSL MI TTZUFI5 DMXBGSL MN Nitric-oxide synthase brain (NOS1) DMXBGSL MT DTT DMXBGSL MA Inhibitor DMXBGSL RN Eusynstyelamides A, B, and C, nNOS inhibitors, from the ascidian Eusynstyela latericius. J Nat Prod. 2009 Jun;72(6):1115-20. DMXBGSL RU https://pubmed.ncbi.nlm.nih.gov/19505081 DM6ODAS DI DM6ODAS DM6ODAS DN Eusynstyelamide C DM6ODAS MI TTZUFI5 DM6ODAS MN Nitric-oxide synthase brain (NOS1) DM6ODAS MT DTT DM6ODAS MA Inhibitor DM6ODAS RN Eusynstyelamides A, B, and C, nNOS inhibitors, from the ascidian Eusynstyela latericius. J Nat Prod. 2009 Jun;72(6):1115-20. DM6ODAS RU https://pubmed.ncbi.nlm.nih.gov/19505081 DMNMEAW DI DMNMEAW DMNMEAW DN Evatak DMNMEAW MI TTMSB0A DMNMEAW MN Integrin alpha-2/beta-1 (ITGA2/B1) DMNMEAW MT DTT DMNMEAW MA Modulator DMNMEAW RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2578). DMNMEAW RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2578 DM17TYR DI DM17TYR DM17TYR DN Everolimus DM17TYR MI TT7HQAF DM17TYR MN HUMAN mammalian target of rapamycin (mTOR) DM17TYR MT DTT DM17TYR MA Inhibitor DM17TYR RN Coronaviruses - drug discovery and therapeutic options. Nat Rev Drug Discov. 2016 May;15(5):327-47. DM17TYR RU https://pubmed.ncbi.nlm.nih.gov/26868298 DMHMFKE DI DMHMFKE DMHMFKE DN EVP-4473 DMHMFKE MI TTLA931 DMHMFKE MN Neuronal acetylcholine receptor alpha-7 (CHRNA7) DMHMFKE MT DTT DMHMFKE MA Agonist DMHMFKE RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 468). DMHMFKE RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=468 DM4Q2HZ DI DM4Q2HZ DM4Q2HZ DN EVT-501 DM4Q2HZ MI TT9JNIC DM4Q2HZ MN Histamine H3 receptor (H3R) DM4Q2HZ MT DTT DM4Q2HZ MA Antagonist DM4Q2HZ RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 264). DM4Q2HZ RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=264 DMBKM30 DI DMBKM30 DMBKM30 DN EX-1311 DMBKM30 MI TTWDC17 DMBKM30 MN Growth hormone secretagogue receptor 1 (GHSR) DMBKM30 MT DTT DMBKM30 MA Antagonist DMBKM30 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 246). DMBKM30 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=246 DMWF8U5 DI DMWF8U5 DMWF8U5 DN EX-1314 DMWF8U5 MI TTWDC17 DMWF8U5 MN Growth hormone secretagogue receptor 1 (GHSR) DMWF8U5 MT DTT DMWF8U5 MA Agonist DMWF8U5 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 246). DMWF8U5 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=246 DMNI6YU DI DMNI6YU DMNI6YU DN EX5 DMNI6YU MI TTQWOU1 DMNI6YU MN MTHFR messenger RNA (MTHFR mRNA) DMNI6YU MT DTT DMNI6YU RN Therapeutic target database update 2012: a resource for facilitating target-oriented drug discovery. Nucleic Acids Res. 2012 Jan;40(Database issue):D1128-36. DMNI6YU RU https://pubmed.ncbi.nlm.nih.gov/21948793 DMSG8RI DI DMSG8RI DMSG8RI DN example 131 [WO2009133348] DMSG8RI MI TT5T3P6 DMSG8RI MN Tissue kallikrein (KLK1) DMSG8RI MT DTT DMSG8RI MA Inhibitor DMSG8RI RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2865). DMSG8RI RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2865 DMY3CKG DI DMY3CKG DMY3CKG DN example 166 (WO2014154727) DMY3CKG MI TT5NILS DMY3CKG MN Cathepsin A (CTSA) DMY3CKG MT DTT DMY3CKG MA Inhibitor DMY3CKG RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1581). DMY3CKG RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1581 DMU25HZ DI DMU25HZ DMU25HZ DN example 2 (WO2013004676) DMU25HZ MI TT8JRS7 DMU25HZ MN Beta-secretase (BACE) DMU25HZ MT DTT DMU25HZ MA Inhibitor DMU25HZ RN Cyclopropyl-Fused 1,3-Thiazepines as BACE1 and BACE2 Inhibitors. ACS Med Chem Lett. 2013 Mar 15;4(4):379-80. DMU25HZ RU https://pubmed.ncbi.nlm.nih.gov/24900681 DMU25HZ DI DMU25HZ DMU25HZ DN example 2 (WO2013004676) DMU25HZ MI TT69DB8 DMU25HZ MN Beta-site APP-cleaving enzyme 2 (BACE2) DMU25HZ MT DTT DMU25HZ MA Inhibitor DMU25HZ RN Cyclopropyl-Fused 1,3-Thiazepines as BACE1 and BACE2 Inhibitors. ACS Med Chem Lett. 2013 Mar 15;4(4):379-80. DMU25HZ RU https://pubmed.ncbi.nlm.nih.gov/24900681 DMF9W41 DI DMF9W41 DMF9W41 DN example 20 (WO2010128058) DMF9W41 MI TT69DB8 DMF9W41 MN Beta-site APP-cleaving enzyme 2 (BACE2) DMF9W41 MT DTT DMF9W41 MA Inhibitor DMF9W41 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2331). DMF9W41 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2331 DMP8A5R DI DMP8A5R DMP8A5R DN example 373 [WO2012093101] DMP8A5R MI TT8D13I DMP8A5R MN Complement factor D (CFD) DMP8A5R MT DTT DMP8A5R MA Inhibitor DMP8A5R RN Factor D Inhibitors for the Treatment of AMD: Patent Highlight. ACS Med Chem Lett. 2012 Aug 27;3(10):781-2. DMP8A5R RU https://pubmed.ncbi.nlm.nih.gov/24900375 DM2N9Y8 DI DM2N9Y8 DM2N9Y8 DN example 41 (WO2012028563) DM2N9Y8 MI TT69DB8 DM2N9Y8 MN Beta-site APP-cleaving enzyme 2 (BACE2) DM2N9Y8 MT DTT DM2N9Y8 MA Inhibitor DM2N9Y8 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2331). DM2N9Y8 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2331 DMFSHXW DI DMFSHXW DMFSHXW DN example 8 [WO1999033801A1] DMFSHXW MI TTQ7R2V DMFSHXW MN Tripeptidyl-peptidase II (TPP2) DMFSHXW MT DTT DMFSHXW MA Inhibitor DMFSHXW RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2423). DMFSHXW RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2423 DMU42CR DI DMU42CR DMU42CR DN example 92 (WO2012095521) DMU42CR MI TT69DB8 DMU42CR MN Beta-site APP-cleaving enzyme 2 (BACE2) DMU42CR MT DTT DMU42CR MA Inhibitor DMU42CR RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2331). DMU42CR RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2331 DMMZH3Q DI DMMZH3Q DMMZH3Q DN Exiguamine A DMMZH3Q MI TTZJYKH DMMZH3Q MN Indoleamine 2,3-dioxygenase 1 (IDO1) DMMZH3Q MT DTT DMMZH3Q MA Inhibitor DMMZH3Q RN Synthesis of indoleamine 2,3-dioxygenase inhibitory analogues of the sponge alkaloid exiguamine A. J Med Chem. 2008 May 8;51(9):2634-7. DMMZH3Q RU https://pubmed.ncbi.nlm.nih.gov/18393489 DME1TGM DI DME1TGM DME1TGM DN EXIGUAMINE B DME1TGM MI TTZJYKH DME1TGM MN Indoleamine 2,3-dioxygenase 1 (IDO1) DME1TGM MT DTT DME1TGM MA Inhibitor DME1TGM RN Biomimetic synthesis of the IDO inhibitors exiguamine A and B. Nat Chem Biol. 2008 Sep;4(9):535-7. DME1TGM RU https://pubmed.ncbi.nlm.nih.gov/18677305 DMWIBFM DI DMWIBFM DMWIBFM DN EXP3174 DMWIBFM MI TT8DBY3 DMWIBFM MN Angiotensin II receptor type-1 (AGTR1) DMWIBFM MT DTT DMWIBFM MA Antagonist DMWIBFM RN Angiotensin II receptors and angiotensin II receptor antagonists. Pharmacol Rev. 1993 Jun;45(2):205-51. DMWIBFM RU https://pubmed.ncbi.nlm.nih.gov/8372104 DMY96KO DI DMY96KO DMY96KO DN EXRD-4605 DMY96KO MI TT7WVHI DMY96KO MN Soluble epoxide hydrolase (EPHX2) DMY96KO MT DTT DMY96KO MA Inhibitor DMY96KO RN Soluble epoxide hydrolase inhibition does not prevent cardiac remodeling and dysfunction after aortic constriction in rats and mice. J Cardiovasc Pharmacol. 2013 Apr;61(4):291-301. DMY96KO RU https://pubmed.ncbi.nlm.nih.gov/23232840 DM5V3S7 DI DM5V3S7 DM5V3S7 DN Ezetimibe-glucuronide DM5V3S7 MI TTPD1CN DM5V3S7 MN Niemann-Pick C1-like protein 1 (NPC1L1) DM5V3S7 MT DTT DM5V3S7 MA Inhibitor DM5V3S7 RN Spiroimidazolidinone NPC1L1 inhibitors. 1: Discovery by 3D-similarity-based virtual screening. Bioorg Med Chem Lett. 2009 Jun 1;19(11):2965-8. DM5V3S7 RU https://pubmed.ncbi.nlm.nih.gov/19410454 DMXV5PM DI DMXV5PM DMXV5PM DN EZN-3920 DMXV5PM MI TTSINU2 DMXV5PM MN ERBB3 messenger RNA (ERBB3 mRNA) DMXV5PM MT DTT DMXV5PM MA Inhibitor DMXV5PM RN Downregulation of HER3 by a novel antisense oligonucleotide, EZN-3920, improves the antitumor activity of EGFR and HER2 tyrosine kinase inhibitors in animal models. Mol Cancer Ther. 2013 Apr;12(4):427-37. DMXV5PM RU https://pubmed.ncbi.nlm.nih.gov/23395887 DMTW571 DI DMTW571 DMTW571 DN F(4-Fluoro)VAE DMTW571 MI TTPADOQ DMTW571 MN HMG-CoA reductase (HMGCR) DMTW571 MT DTT DMTW571 MA Inhibitor DMTW571 RN Binding effect and design of a competitive inhibitory peptide for HMG-CoA reductase through modeling of an active peptide backbone. Bioorg Med Chem. 2008 Feb 1;16(3):1309-18. DMTW571 RU https://pubmed.ncbi.nlm.nih.gov/17977732 DMXHKE3 DI DMXHKE3 DMXHKE3 DN F-12458 DMXHKE3 MI TT7WZIJ DMXHKE3 MN CAAX farnesyltransferase beta (FNTB) DMXHKE3 MT DTT DMXHKE3 MA Inhibitor DMXHKE3 RN Recent progress in protein farnesyltransferase inhibition. IDrugs. 2000 Nov;3(11):1336-45. DMXHKE3 RU https://pubmed.ncbi.nlm.nih.gov/16047255 DMHETZN DI DMHETZN DMHETZN DN F-18 exendin-4 derivative PET tracers DMHETZN MI TTVIMDE DMHETZN MN Glucagon-like peptide 1 receptor (GLP1R) DMHETZN MT DTT DMHETZN MA Modulator DMHETZN RN 2005 approvals: Safety first. Nature Reviews Drug Discovery 5, 92-93 (February 2006). DMHETZN RU http://www.nature.com/nrd/journal/v11/n1/full/nrd3645.html DM69MKU DI DM69MKU DM69MKU DN F3 DM69MKU MI TTTIBVP DM69MKU MN Inward rectifier potassium channel Kir3.2 (KCNJ6) DM69MKU MT DTT DM69MKU MA Inhibitor (gating inhibitor) DM69MKU RN Differential effects of general anesthetics on G protein-coupled inwardly rectifying and other potassium channels. Anesthesiology. 2001 Jul;95(1):144-53. DM69MKU RU https://pubmed.ncbi.nlm.nih.gov/11465552 DMD7HO8 DI DMD7HO8 DMD7HO8 DN F61F12 DMD7HO8 MI TTF0RCZ DMD7HO8 MN Apoptosis mediating surface antigen FAS (FAS) DMD7HO8 MT DTT DMD7HO8 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1875). DMD7HO8 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1875 DMYWERO DI DMYWERO DMYWERO DN F-9TG DMYWERO MI TTFEZ5Q DMYWERO MN Coagulation factor IX (F9) DMYWERO MT DTT DMYWERO MA Modulator DMYWERO RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2364). DMYWERO RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2364 DMDBO89 DI DMDBO89 DMDBO89 DN FA-70 DMDBO89 MI TT3WG5C DMDBO89 MN Monoamine oxidase type A (MAO-A) DMDBO89 MT DTT DMDBO89 MA Inhibitor DMDBO89 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2489). DMDBO89 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2489 DMSQ3I9 DI DMSQ3I9 DMSQ3I9 DN Factor IX-XTEN DMSQ3I9 MI TTFEZ5Q DMSQ3I9 MN Coagulation factor IX (F9) DMSQ3I9 MT DTT DMSQ3I9 MA Modulator DMSQ3I9 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2364). DMSQ3I9 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2364 DM1AYVU DI DM1AYVU DM1AYVU DN Factor VIII-XTEN DM1AYVU MI TT1290U DM1AYVU MN Coagulation factor VIII (F8) DM1AYVU MT DTT DM1AYVU MA Modulator DM1AYVU RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2607). DM1AYVU RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2607 DMDWSH1 DI DMDWSH1 DMDWSH1 DN Factor-VIIa-XTEN DMDWSH1 MI TTF0EGX DMDWSH1 MN Coagulation factor VII (F7) DMDWSH1 MT DTT DMDWSH1 MA Modulator DMDWSH1 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2363). DMDWSH1 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2363 DMJFKSU DI DMJFKSU DMJFKSU DN FAICAR DMJFKSU MI TT9NVXQ DMJFKSU MN Phosphoribosylaminoimidazolecarboxamide formyltransferase (ATIC) DMJFKSU MT DTT DMJFKSU MA Inhibitor DMJFKSU RN Structure-based design, synthesis, evaluation, and crystal structures of transition state analogue inhibitors of inosine monophosphate cyclohydrolase. J Biol Chem. 2007 Apr 27;282(17):13033-46. DMJFKSU RU https://pubmed.ncbi.nlm.nih.gov/17324932 DMLOV18 DI DMLOV18 DMLOV18 DN FALCARINDIOL DMLOV18 MI TTO9X1H DMLOV18 MN 5-HT 7 receptor (HTR7) DMLOV18 MT DTT DMLOV18 MA Inhibitor DMLOV18 RN Serotonergic activity-guided phytochemical investigation of the roots of Angelica sinensis. J Nat Prod. 2006 Apr;69(4):536-41. DMLOV18 RU https://pubmed.ncbi.nlm.nih.gov/16643021 DMLOV18 DI DMLOV18 DMLOV18 DN FALCARINDIOL DMLOV18 MI TTZFYLI DMLOV18 MN Dopamine D1 receptor (D1R) DMLOV18 MT DTT DMLOV18 MA Inhibitor DMLOV18 RN Novel coumarin glycoside and phenethyl vanillate from Notopterygium forbesii and their binding affinities for opioid and dopamine receptors. Bioorg Med Chem. 2008 Mar 15;16(6):3218-23. DMLOV18 RU https://pubmed.ncbi.nlm.nih.gov/18166466 DMLOV18 DI DMLOV18 DMLOV18 DN FALCARINDIOL DMLOV18 MI TT27RFC DMLOV18 MN Opioid receptor delta (OPRD1) DMLOV18 MT DTT DMLOV18 MA Inhibitor DMLOV18 RN Novel coumarin glycoside and phenethyl vanillate from Notopterygium forbesii and their binding affinities for opioid and dopamine receptors. Bioorg Med Chem. 2008 Mar 15;16(6):3218-23. DMLOV18 RU https://pubmed.ncbi.nlm.nih.gov/18166466 DMLOV18 DI DMLOV18 DMLOV18 DN FALCARINDIOL DMLOV18 MI TTQW87Y DMLOV18 MN Opioid receptor kappa (OPRK1) DMLOV18 MT DTT DMLOV18 MA Inhibitor DMLOV18 RN Novel coumarin glycoside and phenethyl vanillate from Notopterygium forbesii and their binding affinities for opioid and dopamine receptors. Bioorg Med Chem. 2008 Mar 15;16(6):3218-23. DMLOV18 RU https://pubmed.ncbi.nlm.nih.gov/18166466 DMLOV18 DI DMLOV18 DMLOV18 DN FALCARINDIOL DMLOV18 MI TTKWM86 DMLOV18 MN Opioid receptor mu (MOP) DMLOV18 MT DTT DMLOV18 MA Inhibitor DMLOV18 RN Novel coumarin glycoside and phenethyl vanillate from Notopterygium forbesii and their binding affinities for opioid and dopamine receptors. Bioorg Med Chem. 2008 Mar 15;16(6):3218-23. DMLOV18 RU https://pubmed.ncbi.nlm.nih.gov/18166466 DMJYNMC DI DMJYNMC DMJYNMC DN FAMOXADONE DMJYNMC MI TTRAMF0 DMJYNMC MN Plasmodium Cytochrome B (Malaria MT-CYB) DMJYNMC MT DTT DMJYNMC MA Inhibitor DMJYNMC RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DMJYNMC RU https://pubmed.ncbi.nlm.nih.gov/10592235 DM45K8W DI DM45K8W DM45K8W DN FANA DM45K8W MI TT50QJ3 DM45K8W MN Influenza Neuraminidase (Influ NA) DM45K8W MT DTT DM45K8W MA Inhibitor DM45K8W RN Antiviral agents active against influenza A viruses. Nat Rev Drug Discov. 2006 Dec;5(12):1015-25. DM45K8W RU https://pubmed.ncbi.nlm.nih.gov/17139286 DMV2X1B DI DMV2X1B DMV2X1B DN Farnesol DMV2X1B MI TTGP7BY DMV2X1B MN Monoamine oxidase type B (MAO-B) DMV2X1B MT DTT DMV2X1B MA Inhibitor DMV2X1B RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DMV2X1B RU https://pubmed.ncbi.nlm.nih.gov/10592235 DMXYWD7 DI DMXYWD7 DMXYWD7 DN FARNESYL DMXYWD7 MI TT7WZIJ DMXYWD7 MN CAAX farnesyltransferase beta (FNTB) DMXYWD7 MT DTT DMXYWD7 MA Inhibitor DMXYWD7 RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DMXYWD7 RU https://pubmed.ncbi.nlm.nih.gov/10592235 DMXYWD7 DI DMXYWD7 DMXYWD7 DN FARNESYL DMXYWD7 MI TTXQKM3 DMXYWD7 MN Farnesyl protein transferase (Ftase) DMXYWD7 MT DTT DMXYWD7 MA Inhibitor DMXYWD7 RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DMXYWD7 RU https://pubmed.ncbi.nlm.nih.gov/10592235 DMRMI0V DI DMRMI0V DMRMI0V DN FAS-031 DMRMI0V MI TT7AOUD DMRMI0V MN Fatty acid synthase (FASN) DMRMI0V MT DTT DMRMI0V MA Inhibitor DMRMI0V RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2608). DMRMI0V RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2608 DMG5OZP DI DMG5OZP DMG5OZP DN Fascaplysin DMG5OZP MI TT0PG8F DMG5OZP MN Cyclin-dependent kinase 4 (CDK4) DMG5OZP MT DTT DMG5OZP MA Inhibitor DMG5OZP RN Pharmacological inhibitors of cyclin-dependent kinases. Trends Pharmacol Sci. 2002 Sep;23(9):417-25. DMG5OZP RU https://pubmed.ncbi.nlm.nih.gov/12237154 DMG5OZP DI DMG5OZP DMG5OZP DN Fascaplysin DMG5OZP MI TTO0FDJ DMG5OZP MN Cyclin-dependent kinase 6 (CDK6) DMG5OZP MT DTT DMG5OZP MA Inhibitor DMG5OZP RN Pharmacological inhibitors of cyclin-dependent kinases. Trends Pharmacol Sci. 2002 Sep;23(9):417-25. DMG5OZP RU https://pubmed.ncbi.nlm.nih.gov/12237154 DMC8G7X DI DMC8G7X DMC8G7X DN fasidotrilat DMC8G7X MI TTL69WB DMC8G7X MN Angiotensin-converting enzyme (ACE) DMC8G7X MT DTT DMC8G7X MA Inhibitor DMC8G7X RN Protease inhibitors in the clinic. Med Chem. 2005 Jan;1(1):71-104. DMC8G7X RU https://pubmed.ncbi.nlm.nih.gov/16789888 DMC8G7X DI DMC8G7X DMC8G7X DN fasidotrilat DMC8G7X MI TT5TKPM DMC8G7X MN Neutral endopeptidase (MME) DMC8G7X MT DTT DMC8G7X MA Inhibitor DMC8G7X RN Modelling of aldose reductase inhibitory activity of pyrrol-1-yl-acetic acid derivatives by means of multivariate statistics. Med Chem. 2005 Jul;1(4):321-6. DMC8G7X RU https://pubmed.ncbi.nlm.nih.gov/16789889 DMTCNOM DI DMTCNOM DMTCNOM DN Fasudil DMTCNOM MI TTZN7RP DMTCNOM MN Rho-associated protein kinase 1 (ROCK1) DMTCNOM MT DTT DMTCNOM MA Inhibitor DMTCNOM RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DMTCNOM RU https://pubmed.ncbi.nlm.nih.gov/10592235 DMC6J3B DI DMC6J3B DMC6J3B DN FAUC 113 DMC6J3B MI TTE0A2F DMC6J3B MN Dopamine D4 receptor (D4R) DMC6J3B MT DTT DMC6J3B MA Antagonist DMC6J3B RN Comparative molecular field analysis of dopamine D4 receptor antagonists including 3-[4-(4-chlorophenyl)piperazin-1-ylmethyl]pyrazolo[1,5-a]pyridine (FAUC 113), 3-[4-(4-chlorophenyl)piperazin-1-ylmethyl]-1H-pyrrolo-[2,3-b]pyridine (L-745,870), and clozapine. J Med Chem. 2001 Apr 12;44(8):1151-7. DMC6J3B RU https://pubmed.ncbi.nlm.nih.gov/11312915 DM1LMFG DI DM1LMFG DM1LMFG DN FAUC213 DM1LMFG MI TTE0A2F DM1LMFG MN Dopamine D4 receptor (D4R) DM1LMFG MT DTT DM1LMFG MA Agonist DM1LMFG RN Certain 1,4-disubstituted aromatic piperidines and piperazines with extreme selectivity for the dopamine D4 receptor interact with a common recepto... Mol Pharmacol. 2004 Dec;66(6):1491-9. DM1LMFG RU https://pubmed.ncbi.nlm.nih.gov/15448188 DM7IEL2 DI DM7IEL2 DM7IEL2 DN FD-1 DM7IEL2 MI TT8R70G DM7IEL2 MN Gonadotropin-releasing hormone receptor (GNRHR) DM7IEL2 MT DTT DM7IEL2 MA Antagonist DM7IEL2 RN Amiloride derivatives and a nonpeptidic antagonist bind at two distinct allosteric sites in the human gonadotropin-releasing hormone receptor. Mol Pharmacol. 2008 Jun;73(6):1808-15. DM7IEL2 RU https://pubmed.ncbi.nlm.nih.gov/18344315 DMYXA7E DI DMYXA7E DMYXA7E DN FdG DMYXA7E MI TTSUKYD DMYXA7E MN Virus RNA-dependent RNA polymerase (Viru RdRP) DMYXA7E MT DTT DMYXA7E MA Inhibitor DMYXA7E RN Activity of T-705 in a hamster model of yellow fever virus infection in comparison with that of a chemically related compound, T-1106. Antimicrob Agents Chemother. 2009 Jan;53(1):202-9. DMYXA7E RU https://pubmed.ncbi.nlm.nih.gov/18955536 DMKVA6Z DI DMKVA6Z DMKVA6Z DN FE 999011 DMKVA6Z MI TTDIGC1 DMKVA6Z MN Dipeptidyl peptidase 4 (DPP-4) DMKVA6Z MT DTT DMKVA6Z MA Inhibitor DMKVA6Z RN Chronic inhibition of circulating dipeptidyl peptidase IV by FE 999011 delays the occurrence of diabetes in male zucker diabetic fatty rats. Diabetes. 2002 May;51(5):1461-9. DMKVA6Z RU https://pubmed.ncbi.nlm.nih.gov/11978643 DMBX81R DI DMBX81R DMBX81R DN FE-203799 DMBX81R MI TT1YWO5 DMBX81R MN Glucagon-like peptide 2 receptor (GLP2R) DMBX81R MT DTT DMBX81R MA Modulator DMBX81R RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 250). DMBX81R RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=250 DM3UCWM DI DM3UCWM DM3UCWM DN FE-999040 DM3UCWM MI TTGPQ0F DM3UCWM MN Prolyl endopeptidase FAP (FAP) DM3UCWM MT DTT DM3UCWM MA Inhibitor DM3UCWM RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2365). DM3UCWM RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2365 DMN1579 DI DMN1579 DMN1579 DN Fedratinib DMN1579 MI TT0F5HE DMN1579 MN HUMAN janus kinase 2 (JAK-2) DMN1579 MT DTT DMN1579 MA Inhibitor DMN1579 RN TH17 responses in cytokine storm of COVID-19: An emerging target of JAK2 inhibitor Fedratinib. J Microbiol Immunol Infect. 2020 Mar 11. pii: S1684-1182(20)30065-7. DMN1579 RU https://pubmed.ncbi.nlm.nih.gov/32205092 DMUBO3E DI DMUBO3E DMUBO3E DN fenclonine DMUBO3E MI TT3KLDP DMUBO3E MN L-Tryptophan hydroxylase 2 (TPH2) DMUBO3E MT DTT DMUBO3E MA Inhibitor DMUBO3E RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1242). DMUBO3E RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1242 DMUBO3E DI DMUBO3E DMUBO3E DN fenclonine DMUBO3E MI TTGSVH2 DMUBO3E MN Phenylalanine hydroxylase (PAH) DMUBO3E MT DTT DMUBO3E MA Inhibitor DMUBO3E RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1240). DMUBO3E RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1240 DMUBO3E DI DMUBO3E DMUBO3E DN fenclonine DMUBO3E MI TTZSJHV DMUBO3E MN Tryptophan 5-hydroxylase 1 (TPH1) DMUBO3E MT DTT DMUBO3E MA Inhibitor DMUBO3E RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1241). DMUBO3E RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1241 DM34V5W DI DM34V5W DM34V5W DN Fenethylline DM34V5W MI DEJGDUW DM34V5W MN Cytochrome P450 1A2 (CYP1A2) DM34V5W MT DME DM34V5W MA Metabolism DM34V5W RN PharmGKB summary: caffeine pathway. Pharmacogenet Genomics. 2012 May;22(5):389-95. DM34V5W RU https://www.ncbi.nlm.nih.gov/pubmed/?term=22293536 DMKEG49 DI DMKEG49 DMKEG49 DN Fenthion DMKEG49 MI DEJVYAZ DMKEG49 MN Cytochrome P450 2A6 (CYP2A6) DMKEG49 MT DME DMKEG49 MA Metabolism DMKEG49 RN The participation of human hepatic P450 isoforms, flavin-containing monooxygenases and aldehyde oxidase in the biotransformation of the insecticide fenthion. Toxicol Appl Pharmacol. 2008 Dec 1;233(2):343-52. DMKEG49 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=18845175 DM4OLRS DI DM4OLRS DM4OLRS DN Fenthion sulfoxide DM4OLRS MI DEJVYAZ DM4OLRS MN Cytochrome P450 2A6 (CYP2A6) DM4OLRS MT DME DM4OLRS MA Metabolism DM4OLRS RN The participation of human hepatic P450 isoforms, flavin-containing monooxygenases and aldehyde oxidase in the biotransformation of the insecticide fenthion. Toxicol Appl Pharmacol. 2008 Dec 1;233(2):343-52. DM4OLRS RU https://www.ncbi.nlm.nih.gov/pubmed/?term=18845175 DM1TH08 DI DM1TH08 DM1TH08 DN Ferricyanide DM1TH08 MI DE4A3BL DM1TH08 MN Diaphorase-1 (CYB5R3) DM1TH08 MT DME DM1TH08 MA Metabolism DM1TH08 RN Expression of a novel P275L variant of NADH:cytochrome b5 reductase gives functional insight into the conserved motif important for pyridine nucleotide binding. Arch Biochem Biophys. 2006 Mar 1;447(1):59-67. DM1TH08 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=16469290 DM1TH08 DI DM1TH08 DM1TH08 DN Ferricyanide DM1TH08 MI DE6NIY9 DM1TH08 MN Methionine synthase reductase (MTRR) DM1TH08 MT DME DM1TH08 MA Metabolism DM1TH08 RN Differences in the efficiency of reductive activation of methionine synthase and exogenous electron acceptors between the common polymorphic variants of human methionine synthase reductase. Biochemistry. 2002 Nov 12;41(45):13378-85. DM1TH08 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=12416982 DMO1N2T DI DMO1N2T DMO1N2T DN FETAV DMO1N2T MI TT9PB26 DMO1N2T MN Presynaptic density protein 95 (DLG4) DMO1N2T MT DTT DMO1N2T MA Inhibitor DMO1N2T RN Modified peptides as potent inhibitors of the postsynaptic density-95/N-methyl-D-aspartate receptor interaction. J Med Chem. 2008 Oct 23;51(20):6450-9. DMO1N2T RU https://pubmed.ncbi.nlm.nih.gov/18811137 DMWCLQ5 DI DMWCLQ5 DMWCLQ5 DN Fexaramine DMWCLQ5 MI TTS4UGC DMWCLQ5 MN Farnesoid X-activated receptor (FXR) DMWCLQ5 MT DTT DMWCLQ5 MA Inhibitor DMWCLQ5 RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMWCLQ5 RU https://pubmed.ncbi.nlm.nih.gov/17139284 DM1NL3Z DI DM1NL3Z DM1NL3Z DN FG-5893 DM1NL3Z MI TTSQIFT DM1NL3Z MN 5-HT 1A receptor (HTR1A) DM1NL3Z MT DTT DM1NL3Z MA Agonist DM1NL3Z RN Agonist and antagonist actions of antipsychotic agents at 5-HT1A receptors: a [35S]GTPgammaS binding study. Eur J Pharmacol. 1998 Aug 21;355(2-3):245-56. DM1NL3Z RU https://pubmed.ncbi.nlm.nih.gov/9760039 DML9IGY DI DML9IGY DML9IGY DN FGGFTCARKCARK DML9IGY MI TTNT7K8 DML9IGY MN Nociceptin receptor (OPRL1) DML9IGY MT DTT DML9IGY MA Inhibitor DML9IGY RN Structure-activity studies on nociceptin analogues: ORL1 receptor binding and biological activity of cyclic disulfide-containing analogues of nocic... J Med Chem. 2001 Nov 8;44(23):4015-8. DML9IGY RU https://pubmed.ncbi.nlm.nih.gov/11689089 DMMV061 DI DMMV061 DMMV061 DN F-G-G-F-T-G-Aib-R-K-S-Aib-R-K-L-A-N-Q-CONH2 DMMV061 MI TTNT7K8 DMMV061 MN Nociceptin receptor (OPRL1) DMMV061 MT DTT DMMV061 MA Inhibitor DMMV061 RN Novel, potent ORL-1 receptor agonist peptides containing alpha-Helix-promoting conformational constraints. J Med Chem. 2002 Nov 21;45(24):5280-6. DMMV061 RU https://pubmed.ncbi.nlm.nih.gov/12431054 DMN7501 DI DMN7501 DMN7501 DN F-G-G-F-T-G-Aib-R-K-S-A-R-K-L-A-N-Q-CONH2 DMN7501 MI TTNT7K8 DMN7501 MN Nociceptin receptor (OPRL1) DMN7501 MT DTT DMN7501 MA Inhibitor DMN7501 RN Novel, potent ORL-1 receptor agonist peptides containing alpha-Helix-promoting conformational constraints. J Med Chem. 2002 Nov 21;45(24):5280-6. DMN7501 RU https://pubmed.ncbi.nlm.nih.gov/12431054 DMU3IJL DI DMU3IJL DMU3IJL DN F-G-G-F-T-G-Aib-R-K-S-A-R-K-L-A-N-Q-COOH DMU3IJL MI TTNT7K8 DMU3IJL MN Nociceptin receptor (OPRL1) DMU3IJL MT DTT DMU3IJL MA Inhibitor DMU3IJL RN Novel, potent ORL-1 receptor agonist peptides containing alpha-Helix-promoting conformational constraints. J Med Chem. 2002 Nov 21;45(24):5280-6. DMU3IJL RU https://pubmed.ncbi.nlm.nih.gov/12431054 DMTEO35 DI DMTEO35 DMTEO35 DN FGGFTGARKCARKC DMTEO35 MI TTNT7K8 DMTEO35 MN Nociceptin receptor (OPRL1) DMTEO35 MT DTT DMTEO35 MA Inhibitor DMTEO35 RN Structure-activity studies on nociceptin analogues: ORL1 receptor binding and biological activity of cyclic disulfide-containing analogues of nocic... J Med Chem. 2001 Nov 8;44(23):4015-8. DMTEO35 RU https://pubmed.ncbi.nlm.nih.gov/11689089 DMIFKPE DI DMIFKPE DMIFKPE DN FGGFTGARKRKRKLANQ DMIFKPE MI TTNT7K8 DMIFKPE MN Nociceptin receptor (OPRL1) DMIFKPE MT DTT DMIFKPE MA Inhibitor DMIFKPE RN Synergistic effect of basic residues at positions 14-15 of nociceptin on binding affinity and receptor activation. Bioorg Med Chem. 2008 Oct 15;16(20):9261-7. DMIFKPE RU https://pubmed.ncbi.nlm.nih.gov/18818087 DM9H80P DI DM9H80P DM9H80P DN F-G-G-F-T-G-A-R-K-S-Aib-R-K-L-A-N-Q-CONH2 DM9H80P MI TTNT7K8 DM9H80P MN Nociceptin receptor (OPRL1) DM9H80P MT DTT DM9H80P MA Inhibitor DM9H80P RN Novel, potent ORL-1 receptor agonist peptides containing alpha-Helix-promoting conformational constraints. J Med Chem. 2002 Nov 21;45(24):5280-6. DM9H80P RU https://pubmed.ncbi.nlm.nih.gov/12431054 DMPRZ8N DI DMPRZ8N DMPRZ8N DN F-G-G-F-T-G-A-R-K-S-Aib-R-K-L-A-N-Q-COOH DMPRZ8N MI TTNT7K8 DMPRZ8N MN Nociceptin receptor (OPRL1) DMPRZ8N MT DTT DMPRZ8N MA Inhibitor DMPRZ8N RN Novel, potent ORL-1 receptor agonist peptides containing alpha-Helix-promoting conformational constraints. J Med Chem. 2002 Nov 21;45(24):5280-6. DMPRZ8N RU https://pubmed.ncbi.nlm.nih.gov/12431054 DM5W1VF DI DM5W1VF DM5W1VF DN FGGFTGARKSARKAANQ DM5W1VF MI TTNT7K8 DM5W1VF MN Nociceptin receptor (OPRL1) DM5W1VF MT DTT DM5W1VF MA Inhibitor DM5W1VF RN Synergistic effect of basic residues at positions 14-15 of nociceptin on binding affinity and receptor activation. Bioorg Med Chem. 2008 Oct 15;16(20):9261-7. DM5W1VF RU https://pubmed.ncbi.nlm.nih.gov/18818087 DMYJTZ7 DI DMYJTZ7 DMYJTZ7 DN FGGFTGARKSARKFANQ DMYJTZ7 MI TTNT7K8 DMYJTZ7 MN Nociceptin receptor (OPRL1) DMYJTZ7 MT DTT DMYJTZ7 MA Inhibitor DMYJTZ7 RN Synergistic effect of basic residues at positions 14-15 of nociceptin on binding affinity and receptor activation. Bioorg Med Chem. 2008 Oct 15;16(20):9261-7. DMYJTZ7 RU https://pubmed.ncbi.nlm.nih.gov/18818087 DMHG2TB DI DMHG2TB DMHG2TB DN FGGFTGARKSARKKANQ DMHG2TB MI TTNT7K8 DMHG2TB MN Nociceptin receptor (OPRL1) DMHG2TB MT DTT DMHG2TB MA Inhibitor DMHG2TB RN Synergistic effect of basic residues at positions 14-15 of nociceptin on binding affinity and receptor activation. Bioorg Med Chem. 2008 Oct 15;16(20):9261-7. DMHG2TB RU https://pubmed.ncbi.nlm.nih.gov/18818087 DMY347Q DI DMY347Q DMY347Q DN FGGFTGARKSARKKKNQ DMY347Q MI TTNT7K8 DMY347Q MN Nociceptin receptor (OPRL1) DMY347Q MT DTT DMY347Q MA Inhibitor DMY347Q RN Synergistic effect of basic residues at positions 14-15 of nociceptin on binding affinity and receptor activation. Bioorg Med Chem. 2008 Oct 15;16(20):9261-7. DMY347Q RU https://pubmed.ncbi.nlm.nih.gov/18818087 DMPG8NC DI DMPG8NC DMPG8NC DN FGGFTGARKSARKKRNQ DMPG8NC MI TTNT7K8 DMPG8NC MN Nociceptin receptor (OPRL1) DMPG8NC MT DTT DMPG8NC MA Inhibitor DMPG8NC RN Synergistic effect of basic residues at positions 14-15 of nociceptin on binding affinity and receptor activation. Bioorg Med Chem. 2008 Oct 15;16(20):9261-7. DMPG8NC RU https://pubmed.ncbi.nlm.nih.gov/18818087 DMHD6N7 DI DMHD6N7 DMHD6N7 DN FGGFTGARKSARKKWNQ DMHD6N7 MI TTNT7K8 DMHD6N7 MN Nociceptin receptor (OPRL1) DMHD6N7 MT DTT DMHD6N7 MA Inhibitor DMHD6N7 RN Discriminatory synergistic effect of Trp-substitutions in superagonist [(Arg/Lys)(14), (Arg/Lys)(15)]nociceptin on ORL1 receptor binding and activa... Bioorg Med Chem. 2009 Aug 1;17(15):5683-7. DMHD6N7 RU https://pubmed.ncbi.nlm.nih.gov/19577933 DM78I2W DI DM78I2W DM78I2W DN FGGFTGARKSARKL DM78I2W MI TTNT7K8 DM78I2W MN Nociceptin receptor (OPRL1) DM78I2W MT DTT DM78I2W MA Inhibitor DM78I2W RN Structure-activity studies on nociceptin analogues: ORL1 receptor binding and biological activity of cyclic disulfide-containing analogues of nocic... J Med Chem. 2001 Nov 8;44(23):4015-8. DM78I2W RU https://pubmed.ncbi.nlm.nih.gov/11689089 DMS5AH4 DI DMS5AH4 DMS5AH4 DN FGGFTGARKSARKLADE DMS5AH4 MI TTNT7K8 DMS5AH4 MN Nociceptin receptor (OPRL1) DMS5AH4 MT DTT DMS5AH4 MA Inhibitor DMS5AH4 RN Structure-activity studies on nociceptin analogues: ORL1 receptor binding and biological activity of cyclic disulfide-containing analogues of nocic... J Med Chem. 2001 Nov 8;44(23):4015-8. DMS5AH4 RU https://pubmed.ncbi.nlm.nih.gov/11689089 DMKLSBN DI DMKLSBN DMKLSBN DN F-G-G-F-T-G-A-R-K-S-A-R-K-L-Aib-N-Q-CONH2 DMKLSBN MI TTNT7K8 DMKLSBN MN Nociceptin receptor (OPRL1) DMKLSBN MT DTT DMKLSBN MA Inhibitor DMKLSBN RN Novel, potent ORL-1 receptor agonist peptides containing alpha-Helix-promoting conformational constraints. J Med Chem. 2002 Nov 21;45(24):5280-6. DMKLSBN RU https://pubmed.ncbi.nlm.nih.gov/12431054 DMPDMFA DI DMPDMFA DMPDMFA DN F-G-G-F-T-G-A-R-K-S-A-R-K-L-Aib-N-Q-COOH DMPDMFA MI TTNT7K8 DMPDMFA MN Nociceptin receptor (OPRL1) DMPDMFA MT DTT DMPDMFA MA Inhibitor DMPDMFA RN Novel, potent ORL-1 receptor agonist peptides containing alpha-Helix-promoting conformational constraints. J Med Chem. 2002 Nov 21;45(24):5280-6. DMPDMFA RU https://pubmed.ncbi.nlm.nih.gov/12431054 DMSMK70 DI DMSMK70 DMSMK70 DN FGGFTGARKSARKLARK DMSMK70 MI TTNT7K8 DMSMK70 MN Nociceptin receptor (OPRL1) DMSMK70 MT DTT DMSMK70 MA Inhibitor DMSMK70 RN Synergistic effect of basic residues at positions 14-15 of nociceptin on binding affinity and receptor activation. Bioorg Med Chem. 2008 Oct 15;16(20):9261-7. DMSMK70 RU https://pubmed.ncbi.nlm.nih.gov/18818087 DMLDWFE DI DMLDWFE DMLDWFE DN FGGFTGARKSARKLFNQ DMLDWFE MI TTNT7K8 DMLDWFE MN Nociceptin receptor (OPRL1) DMLDWFE MT DTT DMLDWFE MA Inhibitor DMLDWFE RN Synergistic effect of basic residues at positions 14-15 of nociceptin on binding affinity and receptor activation. Bioorg Med Chem. 2008 Oct 15;16(20):9261-7. DMLDWFE RU https://pubmed.ncbi.nlm.nih.gov/18818087 DMIA2XJ DI DMIA2XJ DMIA2XJ DN FGGFTGARKSARKLKNQ DMIA2XJ MI TTNT7K8 DMIA2XJ MN Nociceptin receptor (OPRL1) DMIA2XJ MT DTT DMIA2XJ MA Inhibitor DMIA2XJ RN Synergistic effect of basic residues at positions 14-15 of nociceptin on binding affinity and receptor activation. Bioorg Med Chem. 2008 Oct 15;16(20):9261-7. DMIA2XJ RU https://pubmed.ncbi.nlm.nih.gov/18818087 DMRVSXG DI DMRVSXG DMRVSXG DN FGGFTGARKSARKLLNQ DMRVSXG MI TTNT7K8 DMRVSXG MN Nociceptin receptor (OPRL1) DMRVSXG MT DTT DMRVSXG MA Inhibitor DMRVSXG RN Synergistic effect of basic residues at positions 14-15 of nociceptin on binding affinity and receptor activation. Bioorg Med Chem. 2008 Oct 15;16(20):9261-7. DMRVSXG RU https://pubmed.ncbi.nlm.nih.gov/18818087 DMD9SOF DI DMD9SOF DMD9SOF DN F-G-G-F-T-G-A-R-K-S-A-R-K-L-MeA-N-Q-CONH2 DMD9SOF MI TTNT7K8 DMD9SOF MN Nociceptin receptor (OPRL1) DMD9SOF MT DTT DMD9SOF MA Inhibitor DMD9SOF RN Novel, potent ORL-1 receptor agonist peptides containing alpha-Helix-promoting conformational constraints. J Med Chem. 2002 Nov 21;45(24):5280-6. DMD9SOF RU https://pubmed.ncbi.nlm.nih.gov/12431054 DMCSN9M DI DMCSN9M DMCSN9M DN F-G-G-F-T-G-A-R-K-S-A-R-K-L-MeA-N-Q-COOH DMCSN9M MI TTNT7K8 DMCSN9M MN Nociceptin receptor (OPRL1) DMCSN9M MT DTT DMCSN9M MA Inhibitor DMCSN9M RN Novel, potent ORL-1 receptor agonist peptides containing alpha-Helix-promoting conformational constraints. J Med Chem. 2002 Nov 21;45(24):5280-6. DMCSN9M RU https://pubmed.ncbi.nlm.nih.gov/12431054 DMCSTP5 DI DMCSTP5 DMCSTP5 DN FGGFTGARKSARKLRNQ DMCSTP5 MI TTNT7K8 DMCSTP5 MN Nociceptin receptor (OPRL1) DMCSTP5 MT DTT DMCSTP5 MA Inhibitor DMCSTP5 RN Synergistic effect of basic residues at positions 14-15 of nociceptin on binding affinity and receptor activation. Bioorg Med Chem. 2008 Oct 15;16(20):9261-7. DMCSTP5 RU https://pubmed.ncbi.nlm.nih.gov/18818087 DMDEJS6 DI DMDEJS6 DMDEJS6 DN FGGFTGARKSARKLVNQ DMDEJS6 MI TTNT7K8 DMDEJS6 MN Nociceptin receptor (OPRL1) DMDEJS6 MT DTT DMDEJS6 MA Inhibitor DMDEJS6 RN Synergistic effect of basic residues at positions 14-15 of nociceptin on binding affinity and receptor activation. Bioorg Med Chem. 2008 Oct 15;16(20):9261-7. DMDEJS6 RU https://pubmed.ncbi.nlm.nih.gov/18818087 DMV34KQ DI DMV34KQ DMV34KQ DN FGGFTGARKSARKLWNQ DMV34KQ MI TTNT7K8 DMV34KQ MN Nociceptin receptor (OPRL1) DMV34KQ MT DTT DMV34KQ MA Inhibitor DMV34KQ RN Discriminatory synergistic effect of Trp-substitutions in superagonist [(Arg/Lys)(14), (Arg/Lys)(15)]nociceptin on ORL1 receptor binding and activa... Bioorg Med Chem. 2009 Aug 1;17(15):5683-7. DMV34KQ RU https://pubmed.ncbi.nlm.nih.gov/19577933 DMG5LXT DI DMG5LXT DMG5LXT DN FGGFTGARKSARKLYNQ DMG5LXT MI TTNT7K8 DMG5LXT MN Nociceptin receptor (OPRL1) DMG5LXT MT DTT DMG5LXT MA Inhibitor DMG5LXT RN Synergistic effect of basic residues at positions 14-15 of nociceptin on binding affinity and receptor activation. Bioorg Med Chem. 2008 Oct 15;16(20):9261-7. DMG5LXT RU https://pubmed.ncbi.nlm.nih.gov/18818087 DM21XBO DI DM21XBO DM21XBO DN FGGFTGARKSARKRANQ DM21XBO MI TTNT7K8 DM21XBO MN Nociceptin receptor (OPRL1) DM21XBO MT DTT DM21XBO MA Inhibitor DM21XBO RN Synergistic effect of basic residues at positions 14-15 of nociceptin on binding affinity and receptor activation. Bioorg Med Chem. 2008 Oct 15;16(20):9261-7. DM21XBO RU https://pubmed.ncbi.nlm.nih.gov/18818087 DM9RHXC DI DM9RHXC DM9RHXC DN FGGFTGARKSARKRKNQ DM9RHXC MI TTNT7K8 DM9RHXC MN Nociceptin receptor (OPRL1) DM9RHXC MT DTT DM9RHXC MA Inhibitor DM9RHXC RN Discriminatory synergistic effect of Trp-substitutions in superagonist [(Arg/Lys)(14), (Arg/Lys)(15)]nociceptin on ORL1 receptor binding and activa... Bioorg Med Chem. 2009 Aug 1;17(15):5683-7. DM9RHXC RU https://pubmed.ncbi.nlm.nih.gov/19577933 DMWK0Z6 DI DMWK0Z6 DMWK0Z6 DN FGGFTGARKSARKRKRK DMWK0Z6 MI TTNT7K8 DMWK0Z6 MN Nociceptin receptor (OPRL1) DMWK0Z6 MT DTT DMWK0Z6 MA Inhibitor DMWK0Z6 RN Synergistic effect of basic residues at positions 14-15 of nociceptin on binding affinity and receptor activation. Bioorg Med Chem. 2008 Oct 15;16(20):9261-7. DMWK0Z6 RU https://pubmed.ncbi.nlm.nih.gov/18818087 DMDMT5U DI DMDMT5U DMDMT5U DN FGGFTGARKSARKRRNQ DMDMT5U MI TTNT7K8 DMDMT5U MN Nociceptin receptor (OPRL1) DMDMT5U MT DTT DMDMT5U MA Inhibitor DMDMT5U RN Synergistic effect of basic residues at positions 14-15 of nociceptin on binding affinity and receptor activation. Bioorg Med Chem. 2008 Oct 15;16(20):9261-7. DMDMT5U RU https://pubmed.ncbi.nlm.nih.gov/18818087 DMEGW7F DI DMEGW7F DMEGW7F DN FGGFTGARKSARKRWNQ DMEGW7F MI TTNT7K8 DMEGW7F MN Nociceptin receptor (OPRL1) DMEGW7F MT DTT DMEGW7F MA Inhibitor DMEGW7F RN Discriminatory synergistic effect of Trp-substitutions in superagonist [(Arg/Lys)(14), (Arg/Lys)(15)]nociceptin on ORL1 receptor binding and activa... Bioorg Med Chem. 2009 Aug 1;17(15):5683-7. DMEGW7F RU https://pubmed.ncbi.nlm.nih.gov/19577933 DM1QTN5 DI DM1QTN5 DM1QTN5 DN FGGFTGARKSARKVANQ DM1QTN5 MI TTNT7K8 DM1QTN5 MN Nociceptin receptor (OPRL1) DM1QTN5 MT DTT DM1QTN5 MA Inhibitor DM1QTN5 RN Synergistic effect of basic residues at positions 14-15 of nociceptin on binding affinity and receptor activation. Bioorg Med Chem. 2008 Oct 15;16(20):9261-7. DM1QTN5 RU https://pubmed.ncbi.nlm.nih.gov/18818087 DMM17AO DI DMM17AO DMM17AO DN FGGFTGARKSARKWANQ DMM17AO MI TTNT7K8 DMM17AO MN Nociceptin receptor (OPRL1) DMM17AO MT DTT DMM17AO MA Inhibitor DMM17AO RN Discriminatory synergistic effect of Trp-substitutions in superagonist [(Arg/Lys)(14), (Arg/Lys)(15)]nociceptin on ORL1 receptor binding and activa... Bioorg Med Chem. 2009 Aug 1;17(15):5683-7. DMM17AO RU https://pubmed.ncbi.nlm.nih.gov/19577933 DM1YN0F DI DM1YN0F DM1YN0F DN FGGFTGARKSARKWKNQ DM1YN0F MI TTNT7K8 DM1YN0F MN Nociceptin receptor (OPRL1) DM1YN0F MT DTT DM1YN0F MA Inhibitor DM1YN0F RN Discriminatory synergistic effect of Trp-substitutions in superagonist [(Arg/Lys)(14), (Arg/Lys)(15)]nociceptin on ORL1 receptor binding and activa... Bioorg Med Chem. 2009 Aug 1;17(15):5683-7. DM1YN0F RU https://pubmed.ncbi.nlm.nih.gov/19577933 DMRLZKJ DI DMRLZKJ DMRLZKJ DN FGGFTGARKSARKWRNQ DMRLZKJ MI TTNT7K8 DMRLZKJ MN Nociceptin receptor (OPRL1) DMRLZKJ MT DTT DMRLZKJ MA Inhibitor DMRLZKJ RN Discriminatory synergistic effect of Trp-substitutions in superagonist [(Arg/Lys)(14), (Arg/Lys)(15)]nociceptin on ORL1 receptor binding and activa... Bioorg Med Chem. 2009 Aug 1;17(15):5683-7. DMRLZKJ RU https://pubmed.ncbi.nlm.nih.gov/19577933 DM5FRXN DI DM5FRXN DM5FRXN DN FGGFTGARKSARKYANQ DM5FRXN MI TTNT7K8 DM5FRXN MN Nociceptin receptor (OPRL1) DM5FRXN MT DTT DM5FRXN MA Inhibitor DM5FRXN RN Synergistic effect of basic residues at positions 14-15 of nociceptin on binding affinity and receptor activation. Bioorg Med Chem. 2008 Oct 15;16(20):9261-7. DM5FRXN RU https://pubmed.ncbi.nlm.nih.gov/18818087 DMV3ZF1 DI DMV3ZF1 DMV3ZF1 DN F-G-G-F-T-G-A-R-K-S-MeA-R-K-L-A-N-Q-CONH2 DMV3ZF1 MI TTNT7K8 DMV3ZF1 MN Nociceptin receptor (OPRL1) DMV3ZF1 MT DTT DMV3ZF1 MA Inhibitor DMV3ZF1 RN Novel, potent ORL-1 receptor agonist peptides containing alpha-Helix-promoting conformational constraints. J Med Chem. 2002 Nov 21;45(24):5280-6. DMV3ZF1 RU https://pubmed.ncbi.nlm.nih.gov/12431054 DMZI6RD DI DMZI6RD DMZI6RD DN F-G-G-F-T-G-A-R-K-S-MeA-R-K-L-A-N-Q-COOH DMZI6RD MI TTNT7K8 DMZI6RD MN Nociceptin receptor (OPRL1) DMZI6RD MT DTT DMZI6RD MA Inhibitor DMZI6RD RN Novel, potent ORL-1 receptor agonist peptides containing alpha-Helix-promoting conformational constraints. J Med Chem. 2002 Nov 21;45(24):5280-6. DMZI6RD RU https://pubmed.ncbi.nlm.nih.gov/12431054 DM2PYE7 DI DM2PYE7 DM2PYE7 DN FGGFTGCRKSARKC DM2PYE7 MI TTNT7K8 DM2PYE7 MN Nociceptin receptor (OPRL1) DM2PYE7 MT DTT DM2PYE7 MA Inhibitor DM2PYE7 RN Structure-activity studies on nociceptin analogues: ORL1 receptor binding and biological activity of cyclic disulfide-containing analogues of nocic... J Med Chem. 2001 Nov 8;44(23):4015-8. DM2PYE7 RU https://pubmed.ncbi.nlm.nih.gov/11689089 DMQX2GK DI DMQX2GK DMQX2GK DN FGGFTGCRKSCRK DMQX2GK MI TTNT7K8 DMQX2GK MN Nociceptin receptor (OPRL1) DMQX2GK MT DTT DMQX2GK MA Inhibitor DMQX2GK RN Structure-activity studies on nociceptin analogues: ORL1 receptor binding and biological activity of cyclic disulfide-containing analogues of nocic... J Med Chem. 2001 Nov 8;44(23):4015-8. DMQX2GK RU https://pubmed.ncbi.nlm.nih.gov/11689089 DMPHIBZ DI DMPHIBZ DMPHIBZ DN F-G-G-F-T-G-MeA-R-K-S-A-R-K-L-A-N-Q-CONH2 DMPHIBZ MI TTNT7K8 DMPHIBZ MN Nociceptin receptor (OPRL1) DMPHIBZ MT DTT DMPHIBZ MA Inhibitor DMPHIBZ RN Novel, potent ORL-1 receptor agonist peptides containing alpha-Helix-promoting conformational constraints. J Med Chem. 2002 Nov 21;45(24):5280-6. DMPHIBZ RU https://pubmed.ncbi.nlm.nih.gov/12431054 DMXH2D8 DI DMXH2D8 DMXH2D8 DN F-G-G-F-T-G-MeA-R-K-S-A-R-K-L-A-N-Q-COOH DMXH2D8 MI TTNT7K8 DMXH2D8 MN Nociceptin receptor (OPRL1) DMXH2D8 MT DTT DMXH2D8 MA Inhibitor DMXH2D8 RN Novel, potent ORL-1 receptor agonist peptides containing alpha-Helix-promoting conformational constraints. J Med Chem. 2002 Nov 21;45(24):5280-6. DMXH2D8 RU https://pubmed.ncbi.nlm.nih.gov/12431054 DMD9UQN DI DMD9UQN DMD9UQN DN FGGFTRKRKSARKLANQ DMD9UQN MI TTNT7K8 DMD9UQN MN Nociceptin receptor (OPRL1) DMD9UQN MT DTT DMD9UQN MA Inhibitor DMD9UQN RN Synergistic effect of basic residues at positions 14-15 of nociceptin on binding affinity and receptor activation. Bioorg Med Chem. 2008 Oct 15;16(20):9261-7. DMD9UQN RU https://pubmed.ncbi.nlm.nih.gov/18818087 DM4T5DY DI DM4T5DY DM4T5DY DN FGIN-1-27 DM4T5DY MI TTPTXIN DM4T5DY MN Translocator protein (TSPO) DM4T5DY MT DTT DM4T5DY MA Binder DM4T5DY RN Specific ligands of the peripheral benzodiazepine receptor induce apoptosis and cell cycle arrest in human colorectal cancer cells. Br J Cancer. 2001 Nov 30;85(11):1771-80. DM4T5DY RU https://pubmed.ncbi.nlm.nih.gov/11742501 DMH7LDX DI DMH7LDX DMH7LDX DN FHT-2107 DMH7LDX MI TTGKNB4 DMH7LDX MN Epidermal growth factor receptor (EGFR) DMH7LDX MT DTT DMH7LDX RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1797). DMH7LDX RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1797 DMFNTMY DI DMFNTMY DMFNTMY DN Fibrates DMFNTMY MI TTJ584C DMFNTMY MN Peroxisome proliferator-activated receptor alpha (PPARA) DMFNTMY MT DTT DMFNTMY MA Agonist DMFNTMY RN Emerging antidyslipidemic drugs. Expert Opin Emerg Drugs. 2008 Jun;13(2):363-81. DMFNTMY RU https://pubmed.ncbi.nlm.nih.gov/18537526 DMUX702 DI DMUX702 DMUX702 DN Fibronectin extra domain A DMUX702 MI TTISGCA DMUX702 MN Toll-like receptor 4 (TLR4) DMUX702 MT DTT DMUX702 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1754). DMUX702 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1754 DMETVLB DI DMETVLB DMETVLB DN Fidarestat(Stereoisomer) DMETVLB MI TTFBNVI DMETVLB MN Aldose reductase (AKR1B1) DMETVLB MT DTT DMETVLB MA Inhibitor DMETVLB RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMETVLB RU https://pubmed.ncbi.nlm.nih.gov/17139284 DM29TVC DI DM29TVC DM29TVC DN FIG 1 DM29TVC MI TTN7BL9 DM29TVC MN Corticosteroid 11-beta-dehydrogenase 1 (HSD11B1) DM29TVC MT DTT DM29TVC MA Inhibitor DM29TVC RN 4-Methyl-5-phenyl triazoles as selective inhibitors of 11beta-hydroxysteroid dehydrogenase type I. Bioorg Med Chem Lett. 2008 Jun 1;18(11):3405-11. DM29TVC RU https://pubmed.ncbi.nlm.nih.gov/18440811 DMP6GNY DI DMP6GNY DMP6GNY DN Firocoxib DMP6GNY MI TTVKILB DMP6GNY MN Prostaglandin G/H synthase 2 (COX-2) DMP6GNY MT DTT DMP6GNY MA Inhibitor DMP6GNY RN SAR in the alkoxy lactone series: the discovery of DFP, a potent and orally active COX-2 inhibitor. Bioorg Med Chem Lett. 1999 Aug 2;9(15):2207-12. DMP6GNY RU https://pubmed.ncbi.nlm.nih.gov/10465547 DMW2VOX DI DMW2VOX DMW2VOX DN FITC-LMNNAEHINQFYMFI DMW2VOX MI TT7EASG DMW2VOX MN Plasmodium Cysteine protease falcipain-2 (Malaria CPF2) DMW2VOX MT DTT DMW2VOX MA Inhibitor DMW2VOX RN A prodomain peptide of Plasmodium falciparum cysteine protease (falcipain-2) inhibits malaria parasite development. J Med Chem. 2008 Jun 12;51(11):3116-23. DMW2VOX RU https://pubmed.ncbi.nlm.nih.gov/18461922 DM9K834 DI DM9K834 DM9K834 DN FKB-001 DM9K834 MI TTMW94E DM9K834 MN FK506-binding protein 1A (FKBP1A) DM9K834 MT DTT DM9K834 MA Inhibitor DM9K834 RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DM9K834 RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMO7U62 DI DMO7U62 DMO7U62 DN FL104 DMO7U62 MI TTW5UDX DMO7U62 MN Urotensin II receptor (UTS2R) DMO7U62 MT DTT DMO7U62 MA Agonist DMO7U62 RN Novel and potent small-molecule urotensin II receptor agonists. Bioorg Med Chem. 2009 Jul 1;17(13):4657-65. DMO7U62 RU https://pubmed.ncbi.nlm.nih.gov/19481466 DMNWIYM DI DMNWIYM DMNWIYM DN Flavanone DMNWIYM MI DEUX61H DMNWIYM MN Biphenyl dioxygenase (bphC) DMNWIYM MT DME DMNWIYM MA Metabolism DMNWIYM RN Flavonoids biotransformation by bacterial non-heme dioxygenases, biphenyl and naphthalene dioxygenase. Appl Microbiol Biotechnol. 2011 Jul;91(2):219-28. DMNWIYM RU https://pubmed.ncbi.nlm.nih.gov/21626021 DMNWIYM DI DMNWIYM DMNWIYM DN Flavanone DMNWIYM MI TTN7BL9 DMNWIYM MN Corticosteroid 11-beta-dehydrogenase 1 (HSD11B1) DMNWIYM MT DTT DMNWIYM MA Inhibitor DMNWIYM RN A rapid screening assay for inhibitors of 11beta-hydroxysteroid dehydrogenases (11beta-HSD): flavanone selectively inhibits 11beta-HSD1 reductase activity. Mol Cell Endocrinol. 2003 Dec 30;212(1-2):41-9. DMNWIYM RU https://pubmed.ncbi.nlm.nih.gov/14654249 DMNWIYM DI DMNWIYM DMNWIYM DN Flavanone DMNWIYM MI TTGP7BY DMNWIYM MN Monoamine oxidase type B (MAO-B) DMNWIYM MT DTT DMNWIYM MA Inhibitor DMNWIYM RN A new series of flavones, thioflavones, and flavanones as selective monoamine oxidase-B inhibitors. Bioorg Med Chem. 2010 Feb;18(3):1273-9. DMNWIYM RU https://pubmed.ncbi.nlm.nih.gov/20045650 DM5S4GK DI DM5S4GK DM5S4GK DN Flavin-Adenine Dinucleotide DM5S4GK MI TTNAW8S DM5S4GK MN Bacterial Flavohemoglobin (Bact hmp) DM5S4GK MT DTT DM5S4GK MA Inhibitor DM5S4GK RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DM5S4GK RU https://pubmed.ncbi.nlm.nih.gov/17139284 DM5S4GK DI DM5S4GK DM5S4GK DN Flavin-Adenine Dinucleotide DM5S4GK MI TTHDSE2 DM5S4GK MN Bacterial Fumarate reductase flavoprotein (Bact frdA) DM5S4GK MT DTT DM5S4GK MA Inhibitor DM5S4GK RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DM5S4GK RU https://pubmed.ncbi.nlm.nih.gov/17139284 DM5S4GK DI DM5S4GK DM5S4GK DN Flavin-Adenine Dinucleotide DM5S4GK MI TTAEOJ4 DM5S4GK MN Bacterial UDP-N-acetylenolpyruvylglucosamine reductase (Bact murB) DM5S4GK MT DTT DM5S4GK MA Inhibitor DM5S4GK RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DM5S4GK RU https://pubmed.ncbi.nlm.nih.gov/17139284 DM5S4GK DI DM5S4GK DM5S4GK DN Flavin-Adenine Dinucleotide DM5S4GK MI TTR7UJ3 DM5S4GK MN Cytoplasmic thioredoxin reductase (TXNRD1) DM5S4GK MT DTT DM5S4GK MA Inhibitor DM5S4GK RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DM5S4GK RU https://pubmed.ncbi.nlm.nih.gov/17139284 DM5S4GK DI DM5S4GK DM5S4GK DN Flavin-Adenine Dinucleotide DM5S4GK MI TTZPS91 DM5S4GK MN Dihydrothymine dehydrogenase (DPYD) DM5S4GK MT DTT DM5S4GK MA Inhibitor DM5S4GK RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DM5S4GK RU https://pubmed.ncbi.nlm.nih.gov/17139284 DM5S4GK DI DM5S4GK DM5S4GK DN Flavin-Adenine Dinucleotide DM5S4GK MI TTEP6RV DM5S4GK MN Glutathione reductase (GR) DM5S4GK MT DTT DM5S4GK MA Inhibitor DM5S4GK RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DM5S4GK RU https://pubmed.ncbi.nlm.nih.gov/17139284 DM5S4GK DI DM5S4GK DM5S4GK DN Flavin-Adenine Dinucleotide DM5S4GK MI TT3WG5C DM5S4GK MN Monoamine oxidase type A (MAO-A) DM5S4GK MT DTT DM5S4GK MA Inhibitor DM5S4GK RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DM5S4GK RU https://pubmed.ncbi.nlm.nih.gov/17139284 DM5S4GK DI DM5S4GK DM5S4GK DN Flavin-Adenine Dinucleotide DM5S4GK MI TTGP7BY DM5S4GK MN Monoamine oxidase type B (MAO-B) DM5S4GK MT DTT DM5S4GK MA Inhibitor DM5S4GK RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DM5S4GK RU https://pubmed.ncbi.nlm.nih.gov/17139284 DM5S4GK DI DM5S4GK DM5S4GK DN Flavin-Adenine Dinucleotide DM5S4GK MI TTZUFI5 DM5S4GK MN Nitric-oxide synthase brain (NOS1) DM5S4GK MT DTT DM5S4GK MA Inhibitor DM5S4GK RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DM5S4GK RU https://pubmed.ncbi.nlm.nih.gov/17139284 DM5S4GK DI DM5S4GK DM5S4GK DN Flavin-Adenine Dinucleotide DM5S4GK MI TT8XK6L DM5S4GK MN Quinone reductase 1 (NQO1) DM5S4GK MT DTT DM5S4GK MA Inhibitor DM5S4GK RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DM5S4GK RU https://pubmed.ncbi.nlm.nih.gov/17139284 DM5S4GK DI DM5S4GK DM5S4GK DN Flavin-Adenine Dinucleotide DM5S4GK MI TTJLP0R DM5S4GK MN Quinone reductase 2 (NQO2) DM5S4GK MT DTT DM5S4GK MA Inhibitor DM5S4GK RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DM5S4GK RU https://pubmed.ncbi.nlm.nih.gov/17139284 DM5S4GK DI DM5S4GK DM5S4GK DN Flavin-Adenine Dinucleotide DM5S4GK MI TTBKQL3 DM5S4GK MN Trypanosoma Dihydrolipoamide dehydrogenase (Trypano LPD) DM5S4GK MT DTT DM5S4GK MA Inhibitor DM5S4GK RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DM5S4GK RU https://pubmed.ncbi.nlm.nih.gov/17139284 DM5S4GK DI DM5S4GK DM5S4GK DN Flavin-Adenine Dinucleotide DM5S4GK MI TTRTKPV DM5S4GK MN Trypanosoma Trypanothione reductase (Trypano TPR) DM5S4GK MT DTT DM5S4GK MA Inhibitor DM5S4GK RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DM5S4GK RU https://pubmed.ncbi.nlm.nih.gov/17139284 DM5S4GK DI DM5S4GK DM5S4GK DN Flavin-Adenine Dinucleotide DM5S4GK MI TT7RJY8 DM5S4GK MN Xanthine dehydrogenase/oxidase (XDH) DM5S4GK MT DTT DM5S4GK MA Inhibitor DM5S4GK RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DM5S4GK RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMEQH6J DI DMEQH6J DMEQH6J DN Flavone DMEQH6J MI TTK25J1 DMEQH6J MN Adenosine A1 receptor (ADORA1) DMEQH6J MT DTT DMEQH6J MA Antagonist DMEQH6J RN Synthesis and biological activities of flavonoid derivatives as A3 adenosine receptor antagonists. J Med Chem. 1996 Jun 7;39(12):2293-301. DMEQH6J RU https://pubmed.ncbi.nlm.nih.gov/8691424 DMEQH6J DI DMEQH6J DMEQH6J DN Flavone DMEQH6J MI TTNE7KG DMEQH6J MN Adenosine A2b receptor (ADORA2B) DMEQH6J MT DTT DMEQH6J MA Antagonist DMEQH6J RN Synthesis and biological activities of flavonoid derivatives as A3 adenosine receptor antagonists. J Med Chem. 1996 Jun 7;39(12):2293-301. DMEQH6J RU https://pubmed.ncbi.nlm.nih.gov/8691424 DMEQH6J DI DMEQH6J DMEQH6J DN Flavone DMEQH6J MI TTJFY5U DMEQH6J MN Adenosine A3 receptor (ADORA3) DMEQH6J MT DTT DMEQH6J MA Antagonist DMEQH6J RN Synthesis and biological activities of flavonoid derivatives as A3 adenosine receptor antagonists. J Med Chem. 1996 Jun 7;39(12):2293-301. DMEQH6J RU https://pubmed.ncbi.nlm.nih.gov/8691424 DMEQH6J DI DMEQH6J DMEQH6J DN Flavone DMEQH6J MI TTKPW01 DMEQH6J MN Androgen receptor messenger RNA (AR mRNA) DMEQH6J MT DTT DMEQH6J MA Inhibitor DMEQH6J RN Effect of flavonoids on androgen and glucocorticoid receptors based on in vitro reporter gene assay. Bioorg Med Chem Lett. 2009 Aug 15;19(16):4706-10. DMEQH6J RU https://pubmed.ncbi.nlm.nih.gov/19592245 DMEQH6J DI DMEQH6J DMEQH6J DN Flavone DMEQH6J MI TTSZLWK DMEQH6J MN Aromatase (CYP19A1) DMEQH6J MT DTT DMEQH6J MA Inhibitor DMEQH6J RN Pharmacophore modeling strategies for the development of novel nonsteroidal inhibitors of human aromatase (CYP19). Bioorg Med Chem Lett. 2010 May 15;20(10):3050-64. DMEQH6J RU https://pubmed.ncbi.nlm.nih.gov/20413308 DMEQH6J DI DMEQH6J DMEQH6J DN Flavone DMEQH6J MI DEUX61H DMEQH6J MN Biphenyl dioxygenase (bphC) DMEQH6J MT DME DMEQH6J MA Metabolism DMEQH6J RN Flavonoids biotransformation by bacterial non-heme dioxygenases, biphenyl and naphthalene dioxygenase. Appl Microbiol Biotechnol. 2011 Jul;91(2):219-28. DMEQH6J RU https://pubmed.ncbi.nlm.nih.gov/21626021 DMEQH6J DI DMEQH6J DMEQH6J DN Flavone DMEQH6J MI DEJVYAZ DMEQH6J MN Cytochrome P450 2A6 (CYP2A6) DMEQH6J MT DME DMEQH6J MA Metabolism DMEQH6J RN Site-specific oxidation of flavanone and flavone by cytochrome P450 2A6 in human liver microsomes. Xenobiotica. 2019 Jul;49(7):791-802. DMEQH6J RU https://pubmed.ncbi.nlm.nih.gov/30048196 DMEQH6J DI DMEQH6J DMEQH6J DN Flavone DMEQH6J MI TT1MPAY DMEQH6J MN GABA(A) receptor alpha-1 (GABRA1) DMEQH6J MT DTT DMEQH6J MA Inhibitor DMEQH6J RN Synthesis of halogenated/nitrated flavone derivatives and evaluation of their affinity for the central benzodiazepine receptor, Bioorg. Med. Chem. Lett. 7(15):2003-2008 (1997). DMEQH6J RU http://www.sciencedirect.com/science/article/pii/S0960894X97003430 DMEQH6J DI DMEQH6J DMEQH6J DN Flavone DMEQH6J MI TTNJYV2 DMEQH6J MN Gamma-aminobutyric acid receptor (GAR) DMEQH6J MT DTT DMEQH6J MA Inhibitor DMEQH6J RN Refinement and evaluation of a pharmacophore model for flavone derivatives binding to the benzodiazepine site of the GABA(A) receptor. J Med Chem. 2002 Sep 12;45(19):4188-201. DMEQH6J RU https://pubmed.ncbi.nlm.nih.gov/12213060 DMEQH6J DI DMEQH6J DMEQH6J DN Flavone DMEQH6J MI DEE76YZ DMEQH6J MN Naphthalene dioxygenase (doxB) DMEQH6J MT DME DMEQH6J MA Metabolism DMEQH6J RN Flavonoids biotransformation by bacterial non-heme dioxygenases, biphenyl and naphthalene dioxygenase. Appl Microbiol Biotechnol. 2011 Jul;91(2):219-28. DMEQH6J RU https://pubmed.ncbi.nlm.nih.gov/21626021 DMQSDM7 DI DMQSDM7 DMQSDM7 DN FLUANISONE DMQSDM7 MI TTJQOD7 DMQSDM7 MN 5-HT 2A receptor (HTR2A) DMQSDM7 MT DTT DMQSDM7 MA Inhibitor DMQSDM7 RN 2-Phenylpyrroles as conformationally restricted benzamide analogues. A new class of potential antipsychotics. 1. J Med Chem. 1987 Nov;30(11):2099-104. DMQSDM7 RU https://pubmed.ncbi.nlm.nih.gov/2889830 DMQSDM7 DI DMQSDM7 DMQSDM7 DN FLUANISONE DMQSDM7 MI TTNGILX DMQSDM7 MN Adrenergic receptor alpha-1A (ADRA1A) DMQSDM7 MT DTT DMQSDM7 MA Inhibitor DMQSDM7 RN 2-Phenylpyrroles as conformationally restricted benzamide analogues. A new class of potential antipsychotics. 1. J Med Chem. 1987 Nov;30(11):2099-104. DMQSDM7 RU https://pubmed.ncbi.nlm.nih.gov/2889830 DMQSDM7 DI DMQSDM7 DMQSDM7 DN FLUANISONE DMQSDM7 MI TTBRKXS DMQSDM7 MN Adrenergic receptor alpha-1B (ADRA1B) DMQSDM7 MT DTT DMQSDM7 MA Inhibitor DMQSDM7 RN 2-Phenylpyrroles as conformationally restricted benzamide analogues. A new class of potential antipsychotics. 1. J Med Chem. 1987 Nov;30(11):2099-104. DMQSDM7 RU https://pubmed.ncbi.nlm.nih.gov/2889830 DMQSDM7 DI DMQSDM7 DMQSDM7 DN FLUANISONE DMQSDM7 MI TT34BHT DMQSDM7 MN Adrenergic receptor alpha-1D (ADRA1D) DMQSDM7 MT DTT DMQSDM7 MA Inhibitor DMQSDM7 RN 2-Phenylpyrroles as conformationally restricted benzamide analogues. A new class of potential antipsychotics. 1. J Med Chem. 1987 Nov;30(11):2099-104. DMQSDM7 RU https://pubmed.ncbi.nlm.nih.gov/2889830 DMQSDM7 DI DMQSDM7 DMQSDM7 DN FLUANISONE DMQSDM7 MI TTEX248 DMQSDM7 MN Dopamine D2 receptor (D2R) DMQSDM7 MT DTT DMQSDM7 MA Inhibitor DMQSDM7 RN 2-Phenylpyrroles as conformationally restricted benzamide analogues. A new class of potential antipsychotics. 1. J Med Chem. 1987 Nov;30(11):2099-104. DMQSDM7 RU https://pubmed.ncbi.nlm.nih.gov/2889830 DMN8AP0 DI DMN8AP0 DMN8AP0 DN flufenamate DMN8AP0 MI TTAHD89 DMN8AP0 MN Polycystic kidney disease 2-like 1 (TRPP2) DMN8AP0 MT DTT DMN8AP0 MA Blocker (channel blocker) DMN8AP0 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 505). DMN8AP0 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=505 DMN8AP0 DI DMN8AP0 DMN8AP0 DN flufenamate DMN8AP0 MI TTRBT3W DMN8AP0 MN Short transient receptor potential channel 6 (TRPC6) DMN8AP0 MT DTT DMN8AP0 MA Activator DMN8AP0 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 491). DMN8AP0 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=491 DMW0HOG DI DMW0HOG DMW0HOG DN FLUMEZAPINE DMW0HOG MI TTZFYLI DMW0HOG MN Dopamine D1 receptor (D1R) DMW0HOG MT DTT DMW0HOG MA Inhibitor DMW0HOG RN Effects of conformationally restricted 4-piperazinyl-10H-thienobenzodiazepine neuroleptics on central dopaminergic and cholinergic systems. J Med Chem. 1982 Oct;25(10):1133-40. DMW0HOG RU https://pubmed.ncbi.nlm.nih.gov/6128416 DMW0HOG DI DMW0HOG DMW0HOG DN FLUMEZAPINE DMW0HOG MI TTEX248 DMW0HOG MN Dopamine D2 receptor (D2R) DMW0HOG MT DTT DMW0HOG MA Inhibitor DMW0HOG RN Synthesis and pharmacological evaluation of a series of 4-piperazinylpyrazolo[3,4-b]- and -[4,3-b][1,5]benzodiazepines as potential anxiolytics. J Med Chem. 1989 Dec;32(12):2573-82. DMW0HOG RU https://pubmed.ncbi.nlm.nih.gov/2573732 DMW0HOG DI DMW0HOG DMW0HOG DN FLUMEZAPINE DMW0HOG MI TT4C8EA DMW0HOG MN Dopamine D3 receptor (D3R) DMW0HOG MT DTT DMW0HOG MA Inhibitor DMW0HOG RN Effects of conformationally restricted 4-piperazinyl-10H-thienobenzodiazepine neuroleptics on central dopaminergic and cholinergic systems. J Med Chem. 1982 Oct;25(10):1133-40. DMW0HOG RU https://pubmed.ncbi.nlm.nih.gov/6128416 DMW0HOG DI DMW0HOG DMW0HOG DN FLUMEZAPINE DMW0HOG MI TTE0A2F DMW0HOG MN Dopamine D4 receptor (D4R) DMW0HOG MT DTT DMW0HOG MA Inhibitor DMW0HOG RN Effects of conformationally restricted 4-piperazinyl-10H-thienobenzodiazepine neuroleptics on central dopaminergic and cholinergic systems. J Med Chem. 1982 Oct;25(10):1133-40. DMW0HOG RU https://pubmed.ncbi.nlm.nih.gov/6128416 DMW0HOG DI DMW0HOG DMW0HOG DN FLUMEZAPINE DMW0HOG MI TTS2PH3 DMW0HOG MN Dopamine D5 receptor (D5R) DMW0HOG MT DTT DMW0HOG MA Inhibitor DMW0HOG RN Effects of conformationally restricted 4-piperazinyl-10H-thienobenzodiazepine neuroleptics on central dopaminergic and cholinergic systems. J Med Chem. 1982 Oct;25(10):1133-40. DMW0HOG RU https://pubmed.ncbi.nlm.nih.gov/6128416 DMW0HOG DI DMW0HOG DMW0HOG DN FLUMEZAPINE DMW0HOG MI TTZ9SOR DMW0HOG MN Muscarinic acetylcholine receptor M1 (CHRM1) DMW0HOG MT DTT DMW0HOG MA Inhibitor DMW0HOG RN Synthesis and pharmacological evaluation of a series of 4-piperazinylpyrazolo[3,4-b]- and -[4,3-b][1,5]benzodiazepines as potential anxiolytics. J Med Chem. 1989 Dec;32(12):2573-82. DMW0HOG RU https://pubmed.ncbi.nlm.nih.gov/2573732 DMW0HOG DI DMW0HOG DMW0HOG DN FLUMEZAPINE DMW0HOG MI TTYEG6Q DMW0HOG MN Muscarinic acetylcholine receptor M2 (CHRM2) DMW0HOG MT DTT DMW0HOG MA Inhibitor DMW0HOG RN Synthesis and pharmacological evaluation of a series of 4-piperazinylpyrazolo[3,4-b]- and -[4,3-b][1,5]benzodiazepines as potential anxiolytics. J Med Chem. 1989 Dec;32(12):2573-82. DMW0HOG RU https://pubmed.ncbi.nlm.nih.gov/2573732 DMW0HOG DI DMW0HOG DMW0HOG DN FLUMEZAPINE DMW0HOG MI TTQ13Z5 DMW0HOG MN Muscarinic acetylcholine receptor M3 (CHRM3) DMW0HOG MT DTT DMW0HOG MA Inhibitor DMW0HOG RN Synthesis and pharmacological evaluation of a series of 4-piperazinylpyrazolo[3,4-b]- and -[4,3-b][1,5]benzodiazepines as potential anxiolytics. J Med Chem. 1989 Dec;32(12):2573-82. DMW0HOG RU https://pubmed.ncbi.nlm.nih.gov/2573732 DMW0HOG DI DMW0HOG DMW0HOG DN FLUMEZAPINE DMW0HOG MI TTQ3JTF DMW0HOG MN Muscarinic acetylcholine receptor M4 (CHRM4) DMW0HOG MT DTT DMW0HOG MA Inhibitor DMW0HOG RN Synthesis and pharmacological evaluation of a series of 4-piperazinylpyrazolo[3,4-b]- and -[4,3-b][1,5]benzodiazepines as potential anxiolytics. J Med Chem. 1989 Dec;32(12):2573-82. DMW0HOG RU https://pubmed.ncbi.nlm.nih.gov/2573732 DMW0HOG DI DMW0HOG DMW0HOG DN FLUMEZAPINE DMW0HOG MI TTH18TF DMW0HOG MN Muscarinic acetylcholine receptor M5 (CHRM5) DMW0HOG MT DTT DMW0HOG MA Inhibitor DMW0HOG RN Synthesis and pharmacological evaluation of a series of 4-piperazinylpyrazolo[3,4-b]- and -[4,3-b][1,5]benzodiazepines as potential anxiolytics. J Med Chem. 1989 Dec;32(12):2573-82. DMW0HOG RU https://pubmed.ncbi.nlm.nih.gov/2573732 DMLO9FU DI DMLO9FU DMLO9FU DN Fluo-3 DMLO9FU MI DTSYQGK DMLO9FU MN Multidrug resistance-associated protein 1 (ABCC1) DMLO9FU MT DTP DMLO9FU MA Substrate DMLO9FU RN Export pumps for anionic conjugates encoded by MRP genes. Adv Enzyme Regul. 1999;39:237-46. DMLO9FU RU http://www.ncbi.nlm.nih.gov/pubmed/10470375 DMLO9FU DI DMLO9FU DMLO9FU DN Fluo-3 DMLO9FU MI DT3D8F0 DMLO9FU MN Organic anion transporting polypeptide 1B1 (SLCO1B1) DMLO9FU MT DTP DMLO9FU MA Substrate DMLO9FU RN Effect of pregnane X receptor ligands on transport mediated by human OATP1B1 and OATP1B3. Eur J Pharmacol. 2008 Apr 14;584(1):57-65. DMLO9FU RU http://www.ncbi.nlm.nih.gov/pubmed/18321482 DMLO9FU DI DMLO9FU DMLO9FU DN Fluo-3 DMLO9FU MI DT9C1TS DMLO9FU MN Organic anion transporting polypeptide 1B3 (SLCO1B3) DMLO9FU MT DTP DMLO9FU MA Substrate DMLO9FU RN Effect of pregnane X receptor ligands on transport mediated by human OATP1B1 and OATP1B3. Eur J Pharmacol. 2008 Apr 14;584(1):57-65. DMLO9FU RU http://www.ncbi.nlm.nih.gov/pubmed/18321482 DMJS62X DI DMJS62X DMJS62X DN Fluoro loxoprofen DMJS62X MI TTVKILB DMJS62X MN Prostaglandin G/H synthase 2 (COX-2) DMJS62X MT DTT DMJS62X MA Inhibitor DMJS62X RN Properties and synthesis of 2-{2-fluoro (or bromo)-4-[(2-oxocyclopentyl)methyl]phenyl}propanoic acid: nonsteroidal anti-inflammatory drugs with low... J Med Chem. 2010 Nov 11;53(21):7879-82. DMJS62X RU https://pubmed.ncbi.nlm.nih.gov/20954731 DM0LR7G DI DM0LR7G DM0LR7G DN FLUORO-NEPLANOCIN A DM0LR7G MI TTE2KUJ DM0LR7G MN Adenosylhomocysteinase (AHCY) DM0LR7G MT DTT DM0LR7G MA Inhibitor DM0LR7G RN Synthesis of 5'-substituted fluoro-neplanocin A analogues: importance of a hydrogen bonding donor at 5'-position for the inhibitory activity of S-a... Bioorg Med Chem Lett. 2004 Nov 15;14(22):5641-4. DM0LR7G RU https://pubmed.ncbi.nlm.nih.gov/15482939 DMIRBYE DI DMIRBYE DMIRBYE DN Fluoro-Phosphite Ion DMIRBYE MI TTZHY6R DMIRBYE MN Glycogen phosphorylase muscle form (GP) DMIRBYE MT DTT DMIRBYE MA Inhibitor DMIRBYE RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMIRBYE RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMELB5S DI DMELB5S DMELB5S DN Flupentixole DMELB5S MI TTPC4TU DMELB5S MN 5-HT 3A receptor (HTR3A) DMELB5S MT DTT DMELB5S MA Inhibitor DMELB5S RN Molecular properties of psychopharmacological drugs determining non-competitive inhibition of 5-HT3A receptors. Eur J Med Chem. 2009 Jun;44(6):2667-72. DMELB5S RU https://pubmed.ncbi.nlm.nih.gov/19144451 DMELB5S DI DMELB5S DMELB5S DN Flupentixole DMELB5S MI DTUGYRD DMELB5S MN P-glycoprotein 1 (ABCB1) DMELB5S MT DTP DMELB5S MA Substrate DMELB5S RN Mammalian drug efflux transporters of the ATP binding cassette (ABC) family in multidrug resistance: A review of the past decade. Cancer Lett. 2016 Jan 1;370(1):153-64. DMELB5S RU http://www.ncbi.nlm.nih.gov/pubmed/26499806 DMEGL84 DI DMEGL84 DMEGL84 DN FLUPERAMIDE DMEGL84 MI TTNT7K8 DMEGL84 MN Nociceptin receptor (OPRL1) DMEGL84 MT DTT DMEGL84 MA Inhibitor DMEGL84 RN Design and synthesis of 4-phenyl piperidine compounds targeting the mu receptor. Bioorg Med Chem Lett. 2004 Nov 1;14(21):5275-9. DMEGL84 RU https://pubmed.ncbi.nlm.nih.gov/15454210 DMEGL84 DI DMEGL84 DMEGL84 DN FLUPERAMIDE DMEGL84 MI TTKWM86 DMEGL84 MN Opioid receptor mu (MOP) DMEGL84 MT DTT DMEGL84 MA Inhibitor DMEGL84 RN Design and synthesis of 4-phenyl piperidine compounds targeting the mu receptor. Bioorg Med Chem Lett. 2004 Nov 1;14(21):5275-9. DMEGL84 RU https://pubmed.ncbi.nlm.nih.gov/15454210 DM9KIPU DI DM9KIPU DM9KIPU DN fluperlapine DM9KIPU MI TTJS8PY DM9KIPU MN 5-HT 6 receptor (HTR6) DM9KIPU MT DTT DM9KIPU MA Antagonist DM9KIPU RN Binding of typical and atypical antipsychotic agents to 5-hydroxytryptamine-6 and 5-hydroxytryptamine-7 receptors. J Pharmacol Exp Ther. 1994 Mar;268(3):1403-10. DM9KIPU RU https://pubmed.ncbi.nlm.nih.gov/7908055 DM9KIPU DI DM9KIPU DM9KIPU DN fluperlapine DM9KIPU MI TTO9X1H DM9KIPU MN 5-HT 7 receptor (HTR7) DM9KIPU MT DTT DM9KIPU MA Antagonist DM9KIPU RN Binding of typical and atypical antipsychotic agents to 5-hydroxytryptamine-6 and 5-hydroxytryptamine-7 receptors. J Pharmacol Exp Ther. 1994 Mar;268(3):1403-10. DM9KIPU RU https://pubmed.ncbi.nlm.nih.gov/7908055 DM496RP DI DM496RP DM496RP DN Fluphenazine DM496RP MI TTAIY2U DM496RP MN HUMAN clathrin-mediated endocytosis (RME) DM496RP MT DTT DM496RP MA Inhibitor DM496RP RN Repurposing of clinically developed drugs for treatment of Middle East respiratory syndrome coronavirus infection. Antimicrob Agents Chemother. 2014 Aug;58(8):4885-93. DM496RP RU https://pubmed.ncbi.nlm.nih.gov/24841273 DM9Q2PG DI DM9Q2PG DM9Q2PG DN fluprostenol DM9Q2PG MI TTPNGDE DM9Q2PG MN Prostaglandin E2 receptor EP3 (PTGER3) DM9Q2PG MT DTT DM9Q2PG MA Agonist DM9Q2PG RN The utilization of recombinant prostanoid receptors to determine the affinities and selectivities of prostaglandins and related analogs. Biochim Biophys Acta. 2000 Jan 17;1483(2):285-93. DM9Q2PG RU https://pubmed.ncbi.nlm.nih.gov/10634944 DM9Q2PG DI DM9Q2PG DM9Q2PG DN fluprostenol DM9Q2PG MI TTT2ZAR DM9Q2PG MN Prostaglandin F2-alpha receptor (PTGFR) DM9Q2PG MT DTT DM9Q2PG MA Agonist DM9Q2PG RN Ligand binding specificities of the eight types and subtypes of the mouse prostanoid receptors expressed in Chinese hamster ovary cells. Br J Pharmacol. 1997 Sep;122(2):217-24. DM9Q2PG RU https://pubmed.ncbi.nlm.nih.gov/9313928 DM9Q2PG DI DM9Q2PG DM9Q2PG DN fluprostenol DM9Q2PG MI TT2O84V DM9Q2PG MN Thromboxane A2 receptor (TBXA2R) DM9Q2PG MT DTT DM9Q2PG MA Agonist DM9Q2PG RN The utilization of recombinant prostanoid receptors to determine the affinities and selectivities of prostaglandins and related analogs. Biochim Biophys Acta. 2000 Jan 17;1483(2):285-93. DM9Q2PG RU https://pubmed.ncbi.nlm.nih.gov/10634944 DMUOHVL DI DMUOHVL DMUOHVL DN FLUTROLINE DMUOHVL MI TTZFYLI DMUOHVL MN Dopamine D1 receptor (D1R) DMUOHVL MT DTT DMUOHVL MA Inhibitor DMUOHVL RN Neuroleptic activity in 5-aryltetrahydro-gamma-carbolines. J Med Chem. 1980 Jun;23(6):635-43. DMUOHVL RU https://pubmed.ncbi.nlm.nih.gov/6104732 DMUOHVL DI DMUOHVL DMUOHVL DN FLUTROLINE DMUOHVL MI TTEX248 DMUOHVL MN Dopamine D2 receptor (D2R) DMUOHVL MT DTT DMUOHVL MA Inhibitor DMUOHVL RN Neuroleptic activity in 5-aryltetrahydro-gamma-carbolines. J Med Chem. 1980 Jun;23(6):635-43. DMUOHVL RU https://pubmed.ncbi.nlm.nih.gov/6104732 DMUOHVL DI DMUOHVL DMUOHVL DN FLUTROLINE DMUOHVL MI TT4C8EA DMUOHVL MN Dopamine D3 receptor (D3R) DMUOHVL MT DTT DMUOHVL MA Inhibitor DMUOHVL RN Neuroleptic activity in 5-aryltetrahydro-gamma-carbolines. J Med Chem. 1980 Jun;23(6):635-43. DMUOHVL RU https://pubmed.ncbi.nlm.nih.gov/6104732 DMUOHVL DI DMUOHVL DMUOHVL DN FLUTROLINE DMUOHVL MI TTE0A2F DMUOHVL MN Dopamine D4 receptor (D4R) DMUOHVL MT DTT DMUOHVL MA Inhibitor DMUOHVL RN Neuroleptic activity in 5-aryltetrahydro-gamma-carbolines. J Med Chem. 1980 Jun;23(6):635-43. DMUOHVL RU https://pubmed.ncbi.nlm.nih.gov/6104732 DMUOHVL DI DMUOHVL DMUOHVL DN FLUTROLINE DMUOHVL MI TTS2PH3 DMUOHVL MN Dopamine D5 receptor (D5R) DMUOHVL MT DTT DMUOHVL MA Inhibitor DMUOHVL RN Neuroleptic activity in 5-aryltetrahydro-gamma-carbolines. J Med Chem. 1980 Jun;23(6):635-43. DMUOHVL RU https://pubmed.ncbi.nlm.nih.gov/6104732 DMXK6EI DI DMXK6EI DMXK6EI DN FM-101 DMXK6EI MI TT0E5SK DMXK6EI MN Interleukin 6 receptor (IL6R) DMXK6EI MT DTT DMXK6EI MA Modulator DMXK6EI RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2310). DMXK6EI RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2310 DM5782Z DI DM5782Z DM5782Z DN FM1-10 DM5782Z MI TTZ9SOR DM5782Z MN Muscarinic acetylcholine receptor M1 (CHRM1) DM5782Z MT DTT DM5782Z MA Inhibitor DM5782Z RN Design and synthesis of a fluorescent muscarinic antagonist. Bioorg Med Chem Lett. 2008 Jan 15;18(2):825-7. DM5782Z RU https://pubmed.ncbi.nlm.nih.gov/18042383 DM5782Z DI DM5782Z DM5782Z DN FM1-10 DM5782Z MI TTYEG6Q DM5782Z MN Muscarinic acetylcholine receptor M2 (CHRM2) DM5782Z MT DTT DM5782Z MA Inhibitor DM5782Z RN Design and synthesis of a fluorescent muscarinic antagonist. Bioorg Med Chem Lett. 2008 Jan 15;18(2):825-7. DM5782Z RU https://pubmed.ncbi.nlm.nih.gov/18042383 DM5782Z DI DM5782Z DM5782Z DN FM1-10 DM5782Z MI TTQ13Z5 DM5782Z MN Muscarinic acetylcholine receptor M3 (CHRM3) DM5782Z MT DTT DM5782Z MA Inhibitor DM5782Z RN Design and synthesis of a fluorescent muscarinic antagonist. Bioorg Med Chem Lett. 2008 Jan 15;18(2):825-7. DM5782Z RU https://pubmed.ncbi.nlm.nih.gov/18042383 DM5782Z DI DM5782Z DM5782Z DN FM1-10 DM5782Z MI TTQ3JTF DM5782Z MN Muscarinic acetylcholine receptor M4 (CHRM4) DM5782Z MT DTT DM5782Z MA Inhibitor DM5782Z RN Design and synthesis of a fluorescent muscarinic antagonist. Bioorg Med Chem Lett. 2008 Jan 15;18(2):825-7. DM5782Z RU https://pubmed.ncbi.nlm.nih.gov/18042383 DM5782Z DI DM5782Z DM5782Z DN FM1-10 DM5782Z MI TTH18TF DM5782Z MN Muscarinic acetylcholine receptor M5 (CHRM5) DM5782Z MT DTT DM5782Z MA Inhibitor DM5782Z RN Design and synthesis of a fluorescent muscarinic antagonist. Bioorg Med Chem Lett. 2008 Jan 15;18(2):825-7. DM5782Z RU https://pubmed.ncbi.nlm.nih.gov/18042383 DMAP8VY DI DMAP8VY DMAP8VY DN FM1-43 DMAP8VY MI TTZ9SOR DMAP8VY MN Muscarinic acetylcholine receptor M1 (CHRM1) DMAP8VY MT DTT DMAP8VY MA Inhibitor DMAP8VY RN Design and synthesis of a fluorescent muscarinic antagonist. Bioorg Med Chem Lett. 2008 Jan 15;18(2):825-7. DMAP8VY RU https://pubmed.ncbi.nlm.nih.gov/18042383 DMAP8VY DI DMAP8VY DMAP8VY DN FM1-43 DMAP8VY MI TTYEG6Q DMAP8VY MN Muscarinic acetylcholine receptor M2 (CHRM2) DMAP8VY MT DTT DMAP8VY MA Inhibitor DMAP8VY RN Design and synthesis of a fluorescent muscarinic antagonist. Bioorg Med Chem Lett. 2008 Jan 15;18(2):825-7. DMAP8VY RU https://pubmed.ncbi.nlm.nih.gov/18042383 DMAP8VY DI DMAP8VY DMAP8VY DN FM1-43 DMAP8VY MI TTQ13Z5 DMAP8VY MN Muscarinic acetylcholine receptor M3 (CHRM3) DMAP8VY MT DTT DMAP8VY MA Inhibitor DMAP8VY RN Design and synthesis of a fluorescent muscarinic antagonist. Bioorg Med Chem Lett. 2008 Jan 15;18(2):825-7. DMAP8VY RU https://pubmed.ncbi.nlm.nih.gov/18042383 DMAP8VY DI DMAP8VY DMAP8VY DN FM1-43 DMAP8VY MI TTQ3JTF DMAP8VY MN Muscarinic acetylcholine receptor M4 (CHRM4) DMAP8VY MT DTT DMAP8VY MA Inhibitor DMAP8VY RN Design and synthesis of a fluorescent muscarinic antagonist. Bioorg Med Chem Lett. 2008 Jan 15;18(2):825-7. DMAP8VY RU https://pubmed.ncbi.nlm.nih.gov/18042383 DMAP8VY DI DMAP8VY DMAP8VY DN FM1-43 DMAP8VY MI TTH18TF DMAP8VY MN Muscarinic acetylcholine receptor M5 (CHRM5) DMAP8VY MT DTT DMAP8VY MA Inhibitor DMAP8VY RN Design and synthesis of a fluorescent muscarinic antagonist. Bioorg Med Chem Lett. 2008 Jan 15;18(2):825-7. DMAP8VY RU https://pubmed.ncbi.nlm.nih.gov/18042383 DMZRI6H DI DMZRI6H DMZRI6H DN FM-303 DMZRI6H MI TT6H4QR DMZRI6H MN Interleukin 23 receptor (IL23R) DMZRI6H MT DTT DMZRI6H RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2293). DMZRI6H RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2293 DMQ391A DI DMQ391A DMQ391A DN Fmet-leu-phe DMQ391A MI TTOJ1NF DMQ391A MN FMLP-related receptor I (FPR2) DMQ391A MT DTT DMQ391A MA Agonist DMQ391A RN Multiple domains of the N-formyl peptide receptor are required for high-affinity ligand binding. Construction and analysis of chimeric N-formyl peptide receptors. J Biol Chem. 1993 Aug 25;268(24):18167-75. DMQ391A RU https://pubmed.ncbi.nlm.nih.gov/8349692 DMQ391A DI DMQ391A DMQ391A DN Fmet-leu-phe DMQ391A MI TT5Y4EM DMQ391A MN N-formyl peptide receptor (FPR1) DMQ391A MT DTT DMQ391A MA Agonist DMQ391A RN Further studies on the structural requirements for synthetic peptide chemoattractants. Biochemistry. 1980 May 27;19(11):2404-10. DMQ391A RU https://pubmed.ncbi.nlm.nih.gov/7387981 DMW5V9U DI DMW5V9U DMW5V9U DN FMP-825 DMW5V9U MI TTMXGCW DMW5V9U MN Adrenergic receptor beta-3 (ADRB3) DMW5V9U MT DTT DMW5V9U MA Agonist DMW5V9U RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 30). DMW5V9U RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=30 DMQBTL3 DI DMQBTL3 DMQBTL3 DN FMS586 DMQBTL3 MI TTY6EWA DMQBTL3 MN Neuropeptide Y receptor type 5 (NPY5R) DMQBTL3 MT DTT DMQBTL3 MA Antagonist DMQBTL3 RN Pharmacological characterization and feeding-suppressive property of FMS586 [3-(5,6,7,8-tetrahydro-9-isopropyl-carbazol-3-yl)-1-methyl-1-(2-pyridin... J Pharmacol Exp Ther. 2006 May;317(2):562-70. DMQBTL3 RU https://pubmed.ncbi.nlm.nih.gov/16436501 DMJ4F3Q DI DMJ4F3Q DMJ4F3Q DN Folate gamma-hydroxamic acid DMJ4F3Q MI TTLM12X DMJ4F3Q MN Matrix metalloproteinase-2 (MMP-2) DMJ4F3Q MT DTT DMJ4F3Q MA Inhibitor DMJ4F3Q RN Methotrexate gamma-hydroxamate derivatives as potential dual target antitumor drugs. Bioorg Med Chem. 2007 Feb 1;15(3):1266-74. DMJ4F3Q RU https://pubmed.ncbi.nlm.nih.gov/17127067 DMJ4F3Q DI DMJ4F3Q DMJ4F3Q DN Folate gamma-hydroxamic acid DMJ4F3Q MI TTMTWOS DMJ4F3Q MN Matrix metalloproteinase-7 (MMP-7) DMJ4F3Q MT DTT DMJ4F3Q MA Inhibitor DMJ4F3Q RN Methotrexate gamma-hydroxamate derivatives as potential dual target antitumor drugs. Bioorg Med Chem. 2007 Feb 1;15(3):1266-74. DMJ4F3Q RU https://pubmed.ncbi.nlm.nih.gov/17127067 DMJ4F3Q DI DMJ4F3Q DMJ4F3Q DN Folate gamma-hydroxamic acid DMJ4F3Q MI TT6X50U DMJ4F3Q MN Matrix metalloproteinase-9 (MMP-9) DMJ4F3Q MT DTT DMJ4F3Q MA Inhibitor DMJ4F3Q RN Methotrexate gamma-hydroxamate derivatives as potential dual target antitumor drugs. Bioorg Med Chem. 2007 Feb 1;15(3):1266-74. DMJ4F3Q RU https://pubmed.ncbi.nlm.nih.gov/17127067 DM76AUO DI DM76AUO DM76AUO DN Folate gamma-L-phenylalaninehydroxamic acid DM76AUO MI TTMTWOS DM76AUO MN Matrix metalloproteinase-7 (MMP-7) DM76AUO MT DTT DM76AUO MA Inhibitor DM76AUO RN Methotrexate gamma-hydroxamate derivatives as potential dual target antitumor drugs. Bioorg Med Chem. 2007 Feb 1;15(3):1266-74. DM76AUO RU https://pubmed.ncbi.nlm.nih.gov/17127067 DMH5SQV DI DMH5SQV DMH5SQV DN Folate gamma-L-proline-hydroxamic acid DMH5SQV MI TTLM12X DMH5SQV MN Matrix metalloproteinase-2 (MMP-2) DMH5SQV MT DTT DMH5SQV MA Inhibitor DMH5SQV RN Methotrexate gamma-hydroxamate derivatives as potential dual target antitumor drugs. Bioorg Med Chem. 2007 Feb 1;15(3):1266-74. DMH5SQV RU https://pubmed.ncbi.nlm.nih.gov/17127067 DMH5SQV DI DMH5SQV DMH5SQV DN Folate gamma-L-proline-hydroxamic acid DMH5SQV MI TTMTWOS DMH5SQV MN Matrix metalloproteinase-7 (MMP-7) DMH5SQV MT DTT DMH5SQV MA Inhibitor DMH5SQV RN Methotrexate gamma-hydroxamate derivatives as potential dual target antitumor drugs. Bioorg Med Chem. 2007 Feb 1;15(3):1266-74. DMH5SQV RU https://pubmed.ncbi.nlm.nih.gov/17127067 DMEPZ2I DI DMEPZ2I DMEPZ2I DN folipastatin DMEPZ2I MI TT9V5JH DMEPZ2I MN Phospholipase A2 (PLA2G1B) DMEPZ2I MT DTT DMEPZ2I MA Modulator DMEPZ2I RN Folipastatin, a new depsidone compound from Aspergillus unguis as an inhibitor of phospholipase A2.Taxonomy, fermentation, isolation, structure determination and biological properties.J Antibiot (Tokyo).1992 Aug;45(8):1195-201. DMEPZ2I RU https://www.ncbi.nlm.nih.gov/pubmed/1399838 DMSBQL0 DI DMSBQL0 DMSBQL0 DN FOLITENOL DMSBQL0 MI TTELIN2 DMSBQL0 MN PTPN1 messenger RNA (PTPN1 mRNA) DMSBQL0 MT DTT DMSBQL0 MA Inhibitor DMSBQL0 RN Cytotoxic and PTP1B inhibitory activities from Erythrina abyssinica. Bioorg Med Chem Lett. 2009 Dec 1;19(23):6745-9. DMSBQL0 RU https://pubmed.ncbi.nlm.nih.gov/19836230 DM7Q6M0 DI DM7Q6M0 DM7Q6M0 DN Formaldehyde DM7Q6M0 MI TTLP6GN DM7Q6M0 MN Bacterial DD-carboxypeptidase (Bact vanYB) DM7Q6M0 MT DTT DM7Q6M0 MA Inhibitor DM7Q6M0 RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DM7Q6M0 RU https://pubmed.ncbi.nlm.nih.gov/17139284 DM7Q6M0 DI DM7Q6M0 DM7Q6M0 DN Formaldehyde DM7Q6M0 MI TTELV3W DM7Q6M0 MN Transformation-sensitive protein p120 (TRPA1) DM7Q6M0 MT DTT DM7Q6M0 MA Activator DM7Q6M0 RN An ion channel essential for sensing chemical damage. J Neurosci. 2007 Oct 17;27(42):11412-5. DM7Q6M0 RU https://pubmed.ncbi.nlm.nih.gov/17942735 DMNFZC6 DI DMNFZC6 DMNFZC6 DN Formic Acid DMNFZC6 MI TTB30PF DMNFZC6 MN Bacterial Phosphoshikimate1-carboxyvinyltransferase (Bact aroA) DMNFZC6 MT DTT DMNFZC6 MA Inhibitor DMNFZC6 RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMNFZC6 RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMNFZC6 DI DMNFZC6 DMNFZC6 DN Formic Acid DMNFZC6 MI TT915ZD DMNFZC6 MN Candida Mannose-6-phosphate isomerase (Candi PMI1) DMNFZC6 MT DTT DMNFZC6 MA Inhibitor DMNFZC6 RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMNFZC6 RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMNFZC6 DI DMNFZC6 DMNFZC6 DN Formic Acid DMNFZC6 MI TTANPDJ DMNFZC6 MN Carbonic anhydrase II (CA-II) DMNFZC6 MT DTT DMNFZC6 MA Inhibitor DMNFZC6 RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMNFZC6 RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMNFZC6 DI DMNFZC6 DMNFZC6 DN Formic Acid DMNFZC6 MI TTJHKYD DMNFZC6 MN Delta-aminolevulinic acid dehydratase (ALAD) DMNFZC6 MT DTT DMNFZC6 MA Inhibitor DMNFZC6 RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMNFZC6 RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMNFZC6 DI DMNFZC6 DMNFZC6 DN Formic Acid DMNFZC6 MI TTCYE56 DMNFZC6 MN Glutathione-dependent PGD synthase (HPGDS) DMNFZC6 MT DTT DMNFZC6 MA Inhibitor DMNFZC6 RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMNFZC6 RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMNFZC6 DI DMNFZC6 DMNFZC6 DN Formic Acid DMNFZC6 MI TTI6V2A DMNFZC6 MN Heme oxygenase 1 (HMOX1) DMNFZC6 MT DTT DMNFZC6 MA Inhibitor DMNFZC6 RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMNFZC6 RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMNFZC6 DI DMNFZC6 DMNFZC6 DN Formic Acid DMNFZC6 MI TTMY81X DMNFZC6 MN Heparin-binding growth factor 1 (FGF1) DMNFZC6 MT DTT DMNFZC6 MA Inhibitor DMNFZC6 RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMNFZC6 RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMNFZC6 DI DMNFZC6 DMNFZC6 DN Formic Acid DMNFZC6 MI TTZUFI5 DMNFZC6 MN Nitric-oxide synthase brain (NOS1) DMNFZC6 MT DTT DMNFZC6 MA Inhibitor DMNFZC6 RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMNFZC6 RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMNFZC6 DI DMNFZC6 DMNFZC6 DN Formic Acid DMNFZC6 MI TTBL49X DMNFZC6 MN Plasmodium Hypoxanthine-guanine phosphoribosyltransferase (Malaria LACZ) DMNFZC6 MT DTT DMNFZC6 MA Inhibitor DMNFZC6 RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMNFZC6 RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMNFZC6 DI DMNFZC6 DMNFZC6 DN Formic Acid DMNFZC6 MI TTICO5G DMNFZC6 MN Staphylococcus Peptide deformylase (Stap-coc def) DMNFZC6 MT DTT DMNFZC6 MA Inhibitor DMNFZC6 RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMNFZC6 RU https://pubmed.ncbi.nlm.nih.gov/17139284 DM7WFZ8 DI DM7WFZ8 DM7WFZ8 DN Formononetin DM7WFZ8 MI TTF8JAT DM7WFZ8 MN SLC5A2 messenger RNA (SLC5A2 mRNA) DM7WFZ8 MT DTT DM7WFZ8 MA Inhibitor DM7WFZ8 RN Na+-glucose cotransporter (SGLT) inhibitory flavonoids from the roots of Sophora flavescens. Bioorg Med Chem. 2007 May 15;15(10):3445-9. DM7WFZ8 RU https://pubmed.ncbi.nlm.nih.gov/17374486 DMWG0P3 DI DMWG0P3 DMWG0P3 DN Formycin DMWG0P3 MI TTFSX6G DMWG0P3 MN Bacterial MTA/SAH nucleosidase (Bact mtnN) DMWG0P3 MT DTT DMWG0P3 MA Inhibitor DMWG0P3 RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMWG0P3 RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMWG0P3 DI DMWG0P3 DMWG0P3 DN Formycin DMWG0P3 MI TTDBX7N DMWG0P3 MN S-methyl-5'-thioadenosine phosphorylase (MTAP) DMWG0P3 MT DTT DMWG0P3 MA Inhibitor DMWG0P3 RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMWG0P3 RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMHLYUM DI DMHLYUM DMHLYUM DN Formycin B DMHLYUM MI TTBL49X DMHLYUM MN Plasmodium Hypoxanthine-guanine phosphoribosyltransferase (Malaria LACZ) DMHLYUM MT DTT DMHLYUM MA Inhibitor DMHLYUM RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMHLYUM RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMFOU92 DI DMFOU92 DMFOU92 DN FORMYLCHROMONE DMFOU92 MI TTELIN2 DMFOU92 MN PTPN1 messenger RNA (PTPN1 mRNA) DMFOU92 MT DTT DMFOU92 MA Inhibitor DMFOU92 RN Synthesis and evaluation of some novel dibenzo[b,d]furan carboxylic acids as potential anti-diabetic agents. Eur J Med Chem. 2010 Sep;45(9):3709-18. DMFOU92 RU https://pubmed.ncbi.nlm.nih.gov/20627471 DMVBGAT DI DMVBGAT DMVBGAT DN For-RYYRIK-NH2 DMVBGAT MI TTNT7K8 DMVBGAT MN Nociceptin receptor (OPRL1) DMVBGAT MT DTT DMVBGAT MA Inhibitor DMVBGAT RN Designed modification of partial agonist of ORL1 nociceptin receptor for conversion into highly potent antagonist. Bioorg Med Chem. 2008 Mar 1;16(5):2635-44. DMVBGAT RU https://pubmed.ncbi.nlm.nih.gov/18068993 DM6ITNG DI DM6ITNG DM6ITNG DN Forskolin DM6ITNG MI TTBQ9IM DM6ITNG MN Adenylate cyclase type 2 (ADCY2) DM6ITNG MT DTT DM6ITNG MA Inhibitor DM6ITNG RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DM6ITNG RU https://pubmed.ncbi.nlm.nih.gov/10592235 DMPC568 DI DMPC568 DMPC568 DN FORSYTHIASIDE DMPC568 MI TTFJ8Q1 DMPC568 MN Protein kinase C alpha (PRKCA) DMPC568 MT DTT DMPC568 MA Inhibitor DMPC568 RN Phenylethanoid glycosides from Digitalis purpurea and Penstemon linarioides with PKCalpha-inhibitory activity. J Nat Prod. 1998 Nov;61(11):1410-2. DMPC568 RU https://pubmed.ncbi.nlm.nih.gov/9834166 DMYBQN9 DI DMYBQN9 DMYBQN9 DN FP0429 DMYBQN9 MI TTICZ1O DMYBQN9 MN Metabotropic glutamate receptor 4 (mGluR4) DMYBQN9 MT DTT DMYBQN9 MA Agonist DMYBQN9 RN Amino-pyrrolidine tricarboxylic acids give new insight into group III metabotropic glutamate receptor activation mechanism. Mol Pharmacol. 2007 Mar;71(3):704-12. DMYBQN9 RU https://pubmed.ncbi.nlm.nih.gov/17167031 DMGID4T DI DMGID4T DMGID4T DN FP-1102 DMGID4T MI TT7HC21 DMGID4T MN Membrane copper amine oxidase (AOC3) DMGID4T MT DTT DMGID4T MA Inhibitor DMGID4T RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2767). DMGID4T RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2767 DMB8U4F DI DMB8U4F DMB8U4F DN FPL64176 DMB8U4F MI TT94HRF DMB8U4F MN Voltage-gated calcium channel alpha Cav1.1 (CACNA1S) DMB8U4F MT DTT DMB8U4F MA Activator DMB8U4F RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 528). DMB8U4F RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=528 DMB8U4F DI DMB8U4F DMB8U4F DN FPL64176 DMB8U4F MI TTZIFHC DMB8U4F MN Voltage-gated calcium channel alpha Cav1.2 (CACNA1C) DMB8U4F MT DTT DMB8U4F MA Activator DMB8U4F RN The calcium channel ligand FPL 64176 enhances L-type but inhibits N-type neuronal calcium currents. Neuropharmacology. 2003 Aug;45(2):281-92. DMB8U4F RU https://pubmed.ncbi.nlm.nih.gov/12842134 DM0T2LQ DI DM0T2LQ DM0T2LQ DN FPT-038 DM0T2LQ MI TTCBFJO DM0T2LQ MN Insulin receptor (INSR) DM0T2LQ MT DTT DM0T2LQ MA Modulator DM0T2LQ RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1800). DM0T2LQ RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1800 DMR2NBK DI DMR2NBK DMR2NBK DN FPTQ DMR2NBK MI TTVBPDM DMR2NBK MN Metabotropic glutamate receptor 1 (mGluR1) DMR2NBK MT DTT DMR2NBK MA Modulator (allosteric modulator) DMR2NBK RN Synthesis and evaluation of 6-[1-(2-[(18)F]fluoro-3-pyridyl)-5-methyl-1H-1,2,3-triazol-4-yl]quinoline for positron emission tomography imaging of the metabotropic glutamate receptor type 1 in brain. Bioorg Med Chem. 2011 Jan 1;19(1):102-10. DMR2NBK RU https://pubmed.ncbi.nlm.nih.gov/21172734 DMDUR4C DI DMDUR4C DMDUR4C DN FPYVAE peptide DMDUR4C MI TTPADOQ DMDUR4C MN HMG-CoA reductase (HMGCR) DMDUR4C MT DTT DMDUR4C MA Inhibitor DMDUR4C RN Peptide fragmentation as an approach in modeling of an active peptide and designing a competitive inhibitory peptide for HMG-CoA reductase. Bioorg Med Chem. 2010 Jun 15;18(12):4300-9. DMDUR4C RU https://pubmed.ncbi.nlm.nih.gov/20494585 DM7UP4E DI DM7UP4E DM7UP4E DN FR-104 DM7UP4E MI TTQ13FT DM7UP4E MN T-cell-specific surface glycoprotein CD28 (CD28) DM7UP4E MT DTT DM7UP4E RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2863). DM7UP4E RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2863 DM6UWVB DI DM6UWVB DM6UWVB DN FR117016 DM6UWVB MI TTLP57V DM6UWVB MN Adenosine deaminase (ADA) DM6UWVB MT DTT DM6UWVB MA Inhibitor DM6UWVB RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DM6UWVB RU https://pubmed.ncbi.nlm.nih.gov/10592235 DMAYTWN DI DMAYTWN DMAYTWN DN FR122047 DMAYTWN MI TT8NGED DMAYTWN MN Prostaglandin G/H synthase 1 (COX-1) DMAYTWN MT DTT DMAYTWN MA Inhibitor DMAYTWN RN The analgesic effect profile of FR122047, a selective cyclooxygenase-1 inhibitor, in chemical nociceptive models. Eur J Pharmacol. 2000 Mar 10;391(1-2):49-54. DMAYTWN RU https://pubmed.ncbi.nlm.nih.gov/10720634 DMNMO83 DI DMNMO83 DMNMO83 DN FR-122788 DMNMO83 MI TT2J34L DMNMO83 MN Arachidonate 5-lipoxygenase (5-LOX) DMNMO83 MT DTT DMNMO83 MA Modulator DMNMO83 RN Studies on 5-lipoxygenase inhibitors. I. Synthesis and 5-lipoxygenase-inhibitory activity of novel hydroxamic acid derivatives. Chem Pharm Bull (Tokyo). 1998 Jun;46(6):966-72. DMNMO83 RU https://www.ncbi.nlm.nih.gov/pubmed/9658575 DMZSFEP DI DMZSFEP DMZSFEP DN FR161282 DMZSFEP MI TTK8R02 DMZSFEP MN Vasopressin V2 receptor (V2R) DMZSFEP MT DTT DMZSFEP MA Antagonist DMZSFEP RN Nonpeptide vasopressin receptor antagonists: development of selective and orally active V1a, V2 and V1b receptor ligands. Prog Brain Res. 2002;139:197-210. DMZSFEP RU https://pubmed.ncbi.nlm.nih.gov/12436936 DMPCBXT DI DMPCBXT DMPCBXT DN FR-166124 DMPCBXT MI TTK25J1 DMPCBXT MN Adenosine A1 receptor (ADORA1) DMPCBXT MT DTT DMPCBXT MA Inhibitor DMPCBXT RN Discovery of FR166124, a novel water-soluble pyrazolo-[1,5-a]pyridine adenosine A1 receptor antagonist. Bioorg Med Chem Lett. 1999 Jul 19;9(14):1979-84. DMPCBXT RU https://pubmed.ncbi.nlm.nih.gov/10450966 DMPCBXT DI DMPCBXT DMPCBXT DN FR-166124 DMPCBXT MI TTM2AOE DMPCBXT MN Adenosine A2a receptor (ADORA2A) DMPCBXT MT DTT DMPCBXT MA Inhibitor DMPCBXT RN Discovery of FR166124, a novel water-soluble pyrazolo-[1,5-a]pyridine adenosine A1 receptor antagonist. Bioorg Med Chem Lett. 1999 Jul 19;9(14):1979-84. DMPCBXT RU https://pubmed.ncbi.nlm.nih.gov/10450966 DM2W5VA DI DM2W5VA DM2W5VA DN FR167344 DM2W5VA MI TTGY8IW DM2W5VA MN B2 bradykinin receptor (BDKRB2) DM2W5VA MT DTT DM2W5VA MA Antagonist DM2W5VA RN Novel subtype-selective nonpeptide bradykinin receptor antagonists FR167344 and FR173657. Mol Pharmacol. 1997 Feb;51(2):171-6. DM2W5VA RU https://pubmed.ncbi.nlm.nih.gov/9203620 DMQDP23 DI DMQDP23 DMQDP23 DN FR-175985 DMQDP23 MI TTCG0AL DMQDP23 MN Cholecystokinin receptor type A (CCKAR) DMQDP23 MT DTT DMQDP23 MA Inhibitor DMQDP23 RN Dual CCK-A and -B receptor antagonists (I) C9-methyl-1,4-benzodiazepines, Bioorg. Med. Chem. Lett. 7(2):169-174 (1997). DMQDP23 RU http://www.sciencedirect.com/science/article/pii/S0960894X96006099 DM051PI DI DM051PI DM051PI DN FR-180204 DM051PI MI TT4TQBX DM051PI MN Extracellular signal-regulated kinase 2 (ERK2) DM051PI MT DTT DM051PI MA Inhibitor DM051PI RN Crystal structure of human ERK2 complexed with a pyrazolo[3,4-c]pyridazine derivative. Bioorg Med Chem Lett. 2006 Jan 1;16(1):55-8. DM051PI RU https://pubmed.ncbi.nlm.nih.gov/16242327 DM2V7U1 DI DM2V7U1 DM2V7U1 DN FR-181157 DM2V7U1 MI TTOFYT1 DM2V7U1 MN Prostacyclin receptor (PTGIR) DM2V7U1 MT DTT DM2V7U1 MA Inhibitor DM2V7U1 RN Replacing the cyclohexene-linker of FR181157 leading to novel IP receptor agonists: orally active prostacyclin mimetics. Part 6. Bioorg Med Chem Lett. 2006 Sep 15;16(18):4861-4. DM2V7U1 RU https://pubmed.ncbi.nlm.nih.gov/16837197 DM2V7U1 DI DM2V7U1 DM2V7U1 DN FR-181157 DM2V7U1 MI TTPNGDE DM2V7U1 MN Prostaglandin E2 receptor EP3 (PTGER3) DM2V7U1 MT DTT DM2V7U1 MA Inhibitor DM2V7U1 RN Metabolism investigation leading to novel drug design: orally active prostacyclin mimetics. Part 4. Bioorg Med Chem Lett. 2005 Jul 1;15(13):3284-7. DM2V7U1 RU https://pubmed.ncbi.nlm.nih.gov/15935659 DM2V7U1 DI DM2V7U1 DM2V7U1 DN FR-181157 DM2V7U1 MI TT79WV3 DM2V7U1 MN Prostaglandin E2 receptor EP4 (PTGER4) DM2V7U1 MT DTT DM2V7U1 MA Inhibitor DM2V7U1 RN Discovery of diphenyloxazole and Ndelta-Z-ornithine derivatives as highly potent and selective human prostaglandin EP(4) receptor antagonists. J Med Chem. 2005 May 5;48(9):3103-6. DM2V7U1 RU https://pubmed.ncbi.nlm.nih.gov/15857112 DM0G4HP DI DM0G4HP DM0G4HP DN FR190997 DM0G4HP MI TTGY8IW DM0G4HP MN B2 bradykinin receptor (BDKRB2) DM0G4HP MT DTT DM0G4HP MA Agonist DM0G4HP RN Nonpeptide mimic of bradykinin with long-acting properties at the bradykinin B2 receptor. Mol Pharmacol. 1997 Jul;52(1):16-20. DM0G4HP RU https://pubmed.ncbi.nlm.nih.gov/9224807 DM75VHN DI DM75VHN DM75VHN DN FR191413 DM75VHN MI TTGY8IW DM75VHN MN B2 bradykinin receptor (BDKRB2) DM75VHN MT DTT DM75VHN MA Agonist DM75VHN RN Discovery of the first non-peptide full agonists for the human bradykinin B(2) receptor incorporating 4-(2-picolyloxy)quinoline and 1-(2-picolyl)benzimidazole frameworks. J Med Chem. 2004 May 20;47(11):2853-63. DM75VHN RU https://pubmed.ncbi.nlm.nih.gov/15139763 DM9BS3W DI DM9BS3W DM9BS3W DN FR-193262 DM9BS3W MI TTOFYT1 DM9BS3W MN Prostacyclin receptor (PTGIR) DM9BS3W MT DTT DM9BS3W MA Inhibitor DM9BS3W RN Discovery of new diphenyloxazole derivatives containing a pyrrolidine ring: orally active prostacyclin mimetics. Part 2. Bioorg Med Chem Lett. 2005 Jul 1;15(13):3279-83. DM9BS3W RU https://pubmed.ncbi.nlm.nih.gov/15935660 DMISP7G DI DMISP7G DMISP7G DN FR194921 DMISP7G MI TTK25J1 DMISP7G MN Adenosine A1 receptor (ADORA1) DMISP7G MT DTT DMISP7G MA Antagonist DMISP7G RN Pharmacological characterization of FR194921, a new potent, selective, and orally active antagonist for central adenosine A1 receptors. J Pharmacol Sci. 2004 Sep;96(1):42-52. DMISP7G RU https://pubmed.ncbi.nlm.nih.gov/15351792 DM70UQR DI DM70UQR DM70UQR DN FR221647 DM70UQR MI TTLP57V DM70UQR MN Adenosine deaminase (ADA) DM70UQR MT DTT DM70UQR MA Inhibitor DM70UQR RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DM70UQR RU https://pubmed.ncbi.nlm.nih.gov/10592235 DMBY3T5 DI DMBY3T5 DMBY3T5 DN FR-226928 DMBY3T5 MI TTY6EWA DMBY3T5 MN Neuropeptide Y receptor type 5 (NPY5R) DMBY3T5 MT DTT DMBY3T5 MA Inhibitor DMBY3T5 RN Novel potent antagonists of human neuropeptide Y Y5 receptors. Part 3: 7-methoxy-1-hydroxy-1-substituted tetraline derivatives. Bioorg Med Chem Lett. 2002 Mar 11;12(5):799-802. DMBY3T5 RU https://pubmed.ncbi.nlm.nih.gov/11859006 DMKJQWR DI DMKJQWR DMKJQWR DN FR-230481 DMKJQWR MI TTY6EWA DMKJQWR MN Neuropeptide Y receptor type 5 (NPY5R) DMKJQWR MT DTT DMKJQWR MA Inhibitor DMKJQWR RN Novel potent antagonists of human neuropeptide Y Y5 receptors. Part 3: 7-methoxy-1-hydroxy-1-substituted tetraline derivatives. Bioorg Med Chem Lett. 2002 Mar 11;12(5):799-802. DMKJQWR RU https://pubmed.ncbi.nlm.nih.gov/11859006 DM3V0HA DI DM3V0HA DM3V0HA DN FR230513 DM3V0HA MI TTLP57V DM3V0HA MN Adenosine deaminase (ADA) DM3V0HA MT DTT DM3V0HA MA Inhibitor DM3V0HA RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DM3V0HA RU https://pubmed.ncbi.nlm.nih.gov/10592235 DMPD16N DI DMPD16N DMPD16N DN FR-233118 DMPD16N MI TTY6EWA DMPD16N MN Neuropeptide Y receptor type 5 (NPY5R) DMPD16N MT DTT DMPD16N MA Inhibitor DMPD16N RN Novel potent antagonists of human neuropeptide Y Y5 receptors. Part 3: 7-methoxy-1-hydroxy-1-substituted tetraline derivatives. Bioorg Med Chem Lett. 2002 Mar 11;12(5):799-802. DMPD16N RU https://pubmed.ncbi.nlm.nih.gov/11859006 DMR251H DI DMR251H DMR251H DN FR233623 DMR251H MI TTLP57V DMR251H MN Adenosine deaminase (ADA) DMR251H MT DTT DMR251H MA Inhibitor DMR251H RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DMR251H RU https://pubmed.ncbi.nlm.nih.gov/10592235 DMLH546 DI DMLH546 DMLH546 DN FR236913 DMLH546 MI TTLP57V DMLH546 MN Adenosine deaminase (ADA) DMLH546 MT DTT DMLH546 MA Inhibitor DMLH546 RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DMLH546 RU https://pubmed.ncbi.nlm.nih.gov/10592235 DMMJDXT DI DMMJDXT DMMJDXT DN FR239087 DMMJDXT MI TTLP57V DMMJDXT MN Adenosine deaminase (ADA) DMMJDXT MT DTT DMMJDXT MA Inhibitor DMMJDXT RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DMMJDXT RU https://pubmed.ncbi.nlm.nih.gov/10592235 DMSQ6CV DI DMSQ6CV DMSQ6CV DN FR260010 DMSQ6CV MI TTWJBZ5 DMSQ6CV MN 5-HT 2C receptor (HTR2C) DMSQ6CV MT DTT DMSQ6CV MA Antagonist DMSQ6CV RN Anxiolytic activity of a novel potent serotonin 5-HT2C receptor antagonist FR260010: a comparison with diazepam and buspirone. Eur J Pharmacol. 2006 Dec 28;553(1-3):171-84. DMSQ6CV RU https://pubmed.ncbi.nlm.nih.gov/17074317 DMV0UM2 DI DMV0UM2 DMV0UM2 DN FR-73966 DMV0UM2 MI TTY6EWA DMV0UM2 MN Neuropeptide Y receptor type 5 (NPY5R) DMV0UM2 MT DTT DMV0UM2 MA Inhibitor DMV0UM2 RN Novel potent antagonists of human neuropeptide Y Y5 receptors. Part 3: 7-methoxy-1-hydroxy-1-substituted tetraline derivatives. Bioorg Med Chem Lett. 2002 Mar 11;12(5):799-802. DMV0UM2 RU https://pubmed.ncbi.nlm.nih.gov/11859006 DMMGWXQ DI DMMGWXQ DMMGWXQ DN FR-900452 DMMGWXQ MI TTQL5VC DMMGWXQ MN Platelet-activating factor receptor (PTAFR) DMMGWXQ MT DTT DMMGWXQ MA Modulator DMMGWXQ RN FR-900452, a specific antagonist of platelet activating factor (PAF) produced by Streptomyces phaeofaciens. I. Taxonomy, fermentation, isolation, a... J Antibiot (Tokyo). 1986 Feb;39(2):198-204. DMMGWXQ RU https://www.ncbi.nlm.nih.gov/pubmed/3082838 DMEYNGP DI DMEYNGP DMEYNGP DN frescolat MGA DMEYNGP MI TTXDKTO DMEYNGP MN Long transient receptor potential channel 8 (TRPM8) DMEYNGP MT DTT DMEYNGP MA Activator DMEYNGP RN Characterization of the mouse cold-menthol receptor TRPM8 and vanilloid receptor type-1 VR1 using a fluorometric imaging plate reader (FLIPR) assay. Br J Pharmacol. 2004 Feb;141(4):737-45. DMEYNGP RU https://pubmed.ncbi.nlm.nih.gov/14757700 DMIBCZJ DI DMIBCZJ DMIBCZJ DN frescolat ML DMIBCZJ MI TTXDKTO DMIBCZJ MN Long transient receptor potential channel 8 (TRPM8) DMIBCZJ MT DTT DMIBCZJ MA Activator DMIBCZJ RN Characterization of the mouse cold-menthol receptor TRPM8 and vanilloid receptor type-1 VR1 using a fluorometric imaging plate reader (FLIPR) assay. Br J Pharmacol. 2004 Feb;141(4):737-45. DMIBCZJ RU https://pubmed.ncbi.nlm.nih.gov/14757700 DMU5SAF DI DMU5SAF DMU5SAF DN Fructose-6-phosphate DMU5SAF MI DEUZYD1 DMU5SAF MN ATP-dependent 6-phosphofructokinase (pfkA) DMU5SAF MT DME DMU5SAF MA Metabolism DMU5SAF RN Purification and properties of the phosphofructokinase from Lactobacillus bulgaricus. A non-allosteric analog of the enzyme from Escherichia coli. Eur J Biochem. 1991 Jun 15;198(3):683-7. DMU5SAF RU https://pubmed.ncbi.nlm.nih.gov/1828763 DMU5SAF DI DMU5SAF DMU5SAF DN Fructose-6-phosphate DMU5SAF MI TTWHDVK DMU5SAF MN Fructose-1,6-bisphosphatase (FBP) DMU5SAF MT DTT DMU5SAF MA Inhibitor DMU5SAF RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMU5SAF RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMPRMOD DI DMPRMOD DMPRMOD DN FSHR NAM DMPRMOD MI TTZFDBT DMPRMOD MN Follicle-stimulating hormone receptor (FSHR) DMPRMOD MT DTT DMPRMOD MA Modulator DMPRMOD RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 253). DMPRMOD RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=253 DM2KUEV DI DM2KUEV DM2KUEV DN Fsn-0503 DM2KUEV MI TTUMQVO DM2KUEV MN Cathepsin S (CTSS) DM2KUEV MT DTT DM2KUEV RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2353). DM2KUEV RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2353 DMN2Q7Y DI DMN2Q7Y DMN2Q7Y DN FTI 276 DMN2Q7Y MI TT7WZIJ DMN2Q7Y MN CAAX farnesyltransferase beta (FNTB) DMN2Q7Y MT DTT DMN2Q7Y MA Inhibitor DMN2Q7Y RN Ras CAAX peptidomimetic FTI-277 selectively blocks oncogenic Ras signaling by inducing cytoplasmic accumulation of inactive Ras-Raf complexes. J Biol Chem. 1995 Nov 10;270(45):26802-6. DMN2Q7Y RU https://pubmed.ncbi.nlm.nih.gov/7592920 DM65VLB DI DM65VLB DM65VLB DN FTIDC DM65VLB MI TTVBPDM DM65VLB MN Metabotropic glutamate receptor 1 (mGluR1) DM65VLB MT DTT DM65VLB MA Modulator (allosteric modulator) DM65VLB RN Pharmacological characterization of a new, orally active and potent allosteric metabotropic glutamate receptor 1 antagonist, 4-[1-(2-fluoropyridin-... J Pharmacol Exp Ther. 2007 Jun;321(3):1144-53. DM65VLB RU https://pubmed.ncbi.nlm.nih.gov/17360958 DMDZBQH DI DMDZBQH DMDZBQH DN FTY720-phosphate DMDZBQH MI TT9JZCK DMDZBQH MN Sphingosine-1-phosphate receptor 1 (S1PR1) DMDZBQH MT DTT DMDZBQH MA Agonist DMDZBQH RN The immune modulator FTY720 targets sphingosine 1-phosphate receptors. J Biol Chem. 2002 Jun 14;277(24):21453-7. DMDZBQH RU https://pubmed.ncbi.nlm.nih.gov/11967257 DMDZBQH DI DMDZBQH DMDZBQH DN FTY720-phosphate DMDZBQH MI TTDYP7I DMDZBQH MN Sphingosine-1-phosphate receptor 3 (S1PR3) DMDZBQH MT DTT DMDZBQH MA Agonist DMDZBQH RN Immune cell regulation and cardiovascular effects of sphingosine 1-phosphate receptor agonists in rodents are mediated via distinct receptor subtypes. J Pharmacol Exp Ther. 2004 May;309(2):758-68. DMDZBQH RU https://pubmed.ncbi.nlm.nih.gov/14747617 DMDZBQH DI DMDZBQH DMDZBQH DN FTY720-phosphate DMDZBQH MI TTZ8C5Q DMDZBQH MN Sphingosine-1-phosphate receptor 4 (S1PR4) DMDZBQH MT DTT DMDZBQH MA Agonist DMDZBQH RN The immune modulator FTY720 targets sphingosine 1-phosphate receptors. J Biol Chem. 2002 Jun 14;277(24):21453-7. DMDZBQH RU https://pubmed.ncbi.nlm.nih.gov/11967257 DMDZBQH DI DMDZBQH DMDZBQH DN FTY720-phosphate DMDZBQH MI TTDZCKV DMDZBQH MN Sphingosine-1-phosphate receptor 5 (S1PR5) DMDZBQH MT DTT DMDZBQH MA Agonist DMDZBQH RN Immune cell regulation and cardiovascular effects of sphingosine 1-phosphate receptor agonists in rodents are mediated via distinct receptor subtypes. J Pharmacol Exp Ther. 2004 May;309(2):758-68. DMDZBQH RU https://pubmed.ncbi.nlm.nih.gov/14747617 DMUAYWX DI DMUAYWX DMUAYWX DN FUB 349 DMUAYWX MI TT9JNIC DMUAYWX MN Histamine H3 receptor (H3R) DMUAYWX MT DTT DMUAYWX MA Antagonist DMUAYWX RN Distinct pharmacology of rat and human histamine H(3) receptors: role of two amino acids in the third transmembrane domain. Br J Pharmacol. 2000 Dec;131(7):1247-50. DMUAYWX RU https://pubmed.ncbi.nlm.nih.gov/11090094 DMCLSE0 DI DMCLSE0 DMCLSE0 DN FUB-130 DMCLSE0 MI TT9JNIC DMCLSE0 MN Histamine H3 receptor (H3R) DMCLSE0 MT DTT DMCLSE0 MA Antagonist DMCLSE0 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 264). DMCLSE0 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=264 DMAHMSV DI DMAHMSV DMAHMSV DN Fucose DMAHMSV MI TT1RS9F DMAHMSV MN Acetylcholinesterase (AChE) DMAHMSV MT DTT DMAHMSV MA Inhibitor DMAHMSV RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMAHMSV RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMAHMSV DI DMAHMSV DMAHMSV DN Fucose DMAHMSV MI TTIS03D DMAHMSV MN Alpha-galactosidase A (GLA) DMAHMSV MT DTT DMAHMSV MA Inhibitor DMAHMSV RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMAHMSV RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMAHMSV DI DMAHMSV DMAHMSV DN Fucose DMAHMSV MI TTUMQVO DMAHMSV MN Cathepsin S (CTSS) DMAHMSV MT DTT DMAHMSV MA Inhibitor DMAHMSV RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMAHMSV RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMAHMSV DI DMAHMSV DMAHMSV DN Fucose DMAHMSV MI TTEB0GD DMAHMSV MN Cholinesterase (BCHE) DMAHMSV MT DTT DMAHMSV MA Inhibitor DMAHMSV RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMAHMSV RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMAHMSV DI DMAHMSV DMAHMSV DN Fucose DMAHMSV MI TTF0EGX DMAHMSV MN Coagulation factor VII (F7) DMAHMSV MT DTT DMAHMSV MA Inhibitor DMAHMSV RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMAHMSV RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMAHMSV DI DMAHMSV DMAHMSV DN Fucose DMAHMSV MI TT7LRQH DMAHMSV MN Complement C1s component (C1S) DMAHMSV MT DTT DMAHMSV MA Inhibitor DMAHMSV RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMAHMSV RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMAHMSV DI DMAHMSV DMAHMSV DN Fucose DMAHMSV MI TTI2S1D DMAHMSV MN Cytotoxic T-lymphocyte protein 4 (CTLA-4) DMAHMSV MT DTT DMAHMSV MA Inhibitor DMAHMSV RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMAHMSV RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMAHMSV DI DMAHMSV DMAHMSV DN Fucose DMAHMSV MI TTDIGC1 DMAHMSV MN Dipeptidyl peptidase 4 (DPP-4) DMAHMSV MT DTT DMAHMSV MA Inhibitor DMAHMSV RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMAHMSV RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMAHMSV DI DMAHMSV DMAHMSV DN Fucose DMAHMSV MI TTAU4D6 DMAHMSV MN E-selectin (SELE) DMAHMSV MT DTT DMAHMSV MA Inhibitor DMAHMSV RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMAHMSV RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMAHMSV DI DMAHMSV DMAHMSV DN Fucose DMAHMSV MI TTDGEC0 DMAHMSV MN Immunoglobulin epsilon Fc receptor gamma (FCERG) DMAHMSV MT DTT DMAHMSV MA Inhibitor DMAHMSV RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMAHMSV RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMAHMSV DI DMAHMSV DMAHMSV DN Fucose DMAHMSV MI TT50QJ3 DMAHMSV MN Influenza Neuraminidase (Influ NA) DMAHMSV MT DTT DMAHMSV MA Inhibitor DMAHMSV RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMAHMSV RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMAHMSV DI DMAHMSV DMAHMSV DN Fucose DMAHMSV MI TTHRID2 DMAHMSV MN Insulin-like growth factor I receptor (IGF1R) DMAHMSV MT DTT DMAHMSV MA Inhibitor DMAHMSV RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMAHMSV RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMAHMSV DI DMAHMSV DMAHMSV DN Fucose DMAHMSV MI TTA0OSE DMAHMSV MN Lactase-phlorizin hydrolase (LCT) DMAHMSV MT DTT DMAHMSV MA Inhibitor DMAHMSV RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMAHMSV RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMAHMSV DI DMAHMSV DMAHMSV DN Fucose DMAHMSV MI TTSZDQU DMAHMSV MN Lactotransferrin (LTF) DMAHMSV MT DTT DMAHMSV MA Inhibitor DMAHMSV RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMAHMSV RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMAHMSV DI DMAHMSV DMAHMSV DN Fucose DMAHMSV MI TTBXIM9 DMAHMSV MN Membrane-associated lectin type-C (CD209) DMAHMSV MT DTT DMAHMSV MA Inhibitor DMAHMSV RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMAHMSV RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMAHMSV DI DMAHMSV DMAHMSV DN Fucose DMAHMSV MI TTPLTSQ DMAHMSV MN Neutrophil elastase (NE) DMAHMSV MT DTT DMAHMSV MA Inhibitor DMAHMSV RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMAHMSV RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMAHMSV DI DMAHMSV DMAHMSV DN Fucose DMAHMSV MI TTE5VG0 DMAHMSV MN P-selectin (SELP) DMAHMSV MT DTT DMAHMSV MA Inhibitor DMAHMSV RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMAHMSV RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMAHMSV DI DMAHMSV DMAHMSV DN Fucose DMAHMSV MI DTOKC04 DMAHMSV MN Sodium/glucose cotransporter 1 (SLC5A1) DMAHMSV MT DTP DMAHMSV MA Substrate DMAHMSV RN The role of SGLT1 and GLUT2 in intestinal glucose transport and sensing. PLoS One. 2014 Feb 26;9(2):e89977. DMAHMSV RU http://www.ncbi.nlm.nih.gov/pubmed/24587162 DMAHMSV DI DMAHMSV DMAHMSV DN Fucose DMAHMSV MI TTGY7WI DMAHMSV MN Urokinase-type plasminogen activator (PLAU) DMAHMSV MT DTT DMAHMSV MA Inhibitor DMAHMSV RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMAHMSV RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMWF82O DI DMWF82O DMWF82O DN FUKUGETIN DMWF82O MI TT7RJY8 DMWF82O MN Xanthine dehydrogenase/oxidase (XDH) DMWF82O MT DTT DMWF82O MA Inhibitor DMWF82O RN Inhibition of cow's milk xanthine oxidase by flavonoids. J Nat Prod. 1988 Mar-Apr;51(2):345-8. DMWF82O RU https://pubmed.ncbi.nlm.nih.gov/3379415 DM4M91Z DI DM4M91Z DM4M91Z DN Full-length Factor VIII molecule DM4M91Z MI TT1290U DM4M91Z MN Coagulation factor VIII (F8) DM4M91Z MT DTT DM4M91Z MA Modulator DM4M91Z RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2607). DM4M91Z RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2607 DMA3Y8C DI DMA3Y8C DMA3Y8C DN Fumagillin DMA3Y8C MI TTZL0OI DMA3Y8C MN Methionine aminopeptidase 2 (METAP2) DMA3Y8C MT DTT DMA3Y8C MA Binder DMA3Y8C RN Homology modeling and calculation of the cobalt cluster charges of the Encephazlitozoon cuniculi methionine aminopeptidase, a potential target for drug design. Biophys Chem. 2003 Aug 1;105(1):29-43. DMA3Y8C RU https://pubmed.ncbi.nlm.nih.gov/12932577 DM9VLS2 DI DM9VLS2 DM9VLS2 DN Fumarate DM9VLS2 MI TTHDSE2 DM9VLS2 MN Bacterial Fumarate reductase flavoprotein (Bact frdA) DM9VLS2 MT DTT DM9VLS2 MA Inhibitor DM9VLS2 RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DM9VLS2 RU https://pubmed.ncbi.nlm.nih.gov/17139284 DM9VLS2 DI DM9VLS2 DM9VLS2 DN Fumarate DM9VLS2 MI DEQUXZ5 DM9VLS2 MN Fumarate reductase flavoprotein (frdA) DM9VLS2 MT DME DM9VLS2 MA Metabolism DM9VLS2 RN Wolinella succinogenes quinol:fumarate reductase and its comparison to E. coli succinate:quinone reductase. FEBS Lett. 2003 Nov 27;555(1):21-8. DM9VLS2 RU https://pubmed.ncbi.nlm.nih.gov/14630313 DMCFEBW DI DMCFEBW DMCFEBW DN furan-1 DMCFEBW MI TT8R70G DMCFEBW MN Gonadotropin-releasing hormone receptor (GNRHR) DMCFEBW MT DTT DMCFEBW MA Antagonist DMCFEBW RN Biological characterization of a novel, orally active small molecule gonadotropin-releasing hormone (GnRH) antagonist using castrated and intact rats. J Pharmacol Exp Ther. 2003 May;305(2):688-95. DMCFEBW RU https://pubmed.ncbi.nlm.nih.gov/12606616 DM9XPUN DI DM9XPUN DM9XPUN DN Furan-2-ylmethylcarbamic Acid Biphenyl-3-yl Ester DM9XPUN MI TTDP1UC DM9XPUN MN Fatty acid amide hydrolase (FAAH) DM9XPUN MT DTT DM9XPUN MA Inhibitor DM9XPUN RN Synthesis and quantitative structure-activity relationship of fatty acid amide hydrolase inhibitors: modulation at the N-portion of biphenyl-3-yl a... J Med Chem. 2008 Jun 26;51(12):3487-98. DM9XPUN RU https://pubmed.ncbi.nlm.nih.gov/18507372 DMPC6YL DI DMPC6YL DMPC6YL DN Furan-3-yl(4-(methylsulfonyl)phenyl)methanone DMPC6YL MI TTVKILB DMPC6YL MN Prostaglandin G/H synthase 2 (COX-2) DMPC6YL MT DTT DMPC6YL MA Inhibitor DMPC6YL RN Synthesis, anti-inflammatory activity, and in vitro antitumor effect of a novel class of cyclooxygenase inhibitors: 4-(aryloyl)phenyl methyl sulfones. J Med Chem. 2010 Sep 23;53(18):6560-71. DMPC6YL RU https://pubmed.ncbi.nlm.nih.gov/20804197 DM78NOM DI DM78NOM DM78NOM DN furin inhibitor peptide DM78NOM MI TTH9WF6 DM78NOM MN Dibasic-processing enzyme (Furin) DM78NOM MT DTT DM78NOM MA Inhibitor DM78NOM RN Targeting host cell furin proprotein convertases as a therapeutic strategy against bacterial toxins and viral pathogens. J Biol Chem. 2007 Jul 20;282(29):20847-53. DM78NOM RU https://pubmed.ncbi.nlm.nih.gov/17537721 DM78NOM DI DM78NOM DM78NOM DN furin inhibitor peptide DM78NOM MI TTK3VYC DM78NOM MN Proprotein convertase subtilisin/kexin type 4 (PCSK4) DM78NOM MT DTT DM78NOM MA Inhibitor DM78NOM RN Targeting host cell furin proprotein convertases as a therapeutic strategy against bacterial toxins and viral pathogens. J Biol Chem. 2007 Jul 20;282(29):20847-53. DM78NOM RU https://pubmed.ncbi.nlm.nih.gov/17537721 DM78NOM DI DM78NOM DM78NOM DN furin inhibitor peptide DM78NOM MI TTPFWHU DM78NOM MN Proprotein convertase subtilisin/kexin type 5 (PCSK5) DM78NOM MT DTT DM78NOM MA Inhibitor DM78NOM RN Targeting host cell furin proprotein convertases as a therapeutic strategy against bacterial toxins and viral pathogens. J Biol Chem. 2007 Jul 20;282(29):20847-53. DM78NOM RU https://pubmed.ncbi.nlm.nih.gov/17537721 DM78NOM DI DM78NOM DM78NOM DN furin inhibitor peptide DM78NOM MI TT75LN9 DM78NOM MN Proprotein convertase subtilisin/kexin type 6 (PCSK6) DM78NOM MT DTT DM78NOM MA Inhibitor DM78NOM RN Targeting host cell furin proprotein convertases as a therapeutic strategy against bacterial toxins and viral pathogens. J Biol Chem. 2007 Jul 20;282(29):20847-53. DM78NOM RU https://pubmed.ncbi.nlm.nih.gov/17537721 DM78NOM DI DM78NOM DM78NOM DN furin inhibitor peptide DM78NOM MI TTD30LY DM78NOM MN Proprotein convertase subtilisin/kexin type 7 (PCSK7) DM78NOM MT DTT DM78NOM MA Inhibitor DM78NOM RN Targeting host cell furin proprotein convertases as a therapeutic strategy against bacterial toxins and viral pathogens. J Biol Chem. 2007 Jul 20;282(29):20847-53. DM78NOM RU https://pubmed.ncbi.nlm.nih.gov/17537721 DMVYEZ1 DI DMVYEZ1 DMVYEZ1 DN Furo[2,3d]Pyrimidine Antifolate DMVYEZ1 MI TT9SL3Q DMVYEZ1 MN Polypeptide deformylase (PDF) DMVYEZ1 MT DTT DMVYEZ1 MA Inhibitor DMVYEZ1 RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMVYEZ1 RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMVT0JO DI DMVT0JO DMVT0JO DN FUROSIN DMVT0JO MI TTE14XG DMVT0JO MN Squalene monooxygenase (SQLE) DMVT0JO MT DTT DMVT0JO MA Inhibitor DMVT0JO RN Ellagitannins and hexahydroxydiphenoyl esters as inhibitors of vertebrate squalene epoxidase. J Nat Prod. 2001 Aug;64(8):1010-4. DMVT0JO RU https://pubmed.ncbi.nlm.nih.gov/11520216 DM4M3C8 DI DM4M3C8 DM4M3C8 DN furtrethonium DM4M3C8 MI TTOXS3C DM4M3C8 MN Muscarinic acetylcholine receptor (CHRM) DM4M3C8 MT DTT DM4M3C8 MA Agonist DM4M3C8 RN Positive cooperativity of acetylcholine and other agonists with allosteric ligands on muscarinic acetylcholine receptors. Mol Pharmacol. 1997 Jul;52(1):172-9. DM4M3C8 RU https://pubmed.ncbi.nlm.nih.gov/9224827 DM4M3C8 DI DM4M3C8 DM4M3C8 DN furtrethonium DM4M3C8 MI TTQ13Z5 DM4M3C8 MN Muscarinic acetylcholine receptor M3 (CHRM3) DM4M3C8 MT DTT DM4M3C8 MA Agonist DM4M3C8 RN Positive cooperativity of acetylcholine and other agonists with allosteric ligands on muscarinic acetylcholine receptors. Mol Pharmacol. 1997 Jul;52(1):172-9. DM4M3C8 RU https://pubmed.ncbi.nlm.nih.gov/9224827 DMP3BZH DI DMP3BZH DMP3BZH DN Fusion peptide EK1 DMP3BZH MI TT854FJ DMP3BZH MN MERS-CoV spike glycoprotein S2' HR1 region (S S2'HR1) DMP3BZH MT DTT DMP3BZH MA Inhibitor DMP3BZH RN A pan-coronavirus fusion inhibitor targeting the HR1 domain of human coronavirus spike. Sci Adv. 2019 Apr 10;5(4):eaav4580. DMP3BZH RU https://pubmed.ncbi.nlm.nih.gov/30989115 DMP3BZH DI DMP3BZH DMP3BZH DN Fusion peptide EK1 DMP3BZH MI TTXMITO DMP3BZH MN SARS-CoV spike glycoprotein S2' HR1 region (S S2'HR1) DMP3BZH MT DTT DMP3BZH MA Inhibitor DMP3BZH RN A pan-coronavirus fusion inhibitor targeting the HR1 domain of human coronavirus spike. Sci Adv. 2019 Apr 10;5(4):eaav4580. DMP3BZH RU https://pubmed.ncbi.nlm.nih.gov/30989115 DMFBP7C DI DMFBP7C DMFBP7C DN FUTOENONE DMFBP7C MI TTUZ2L5 DMFBP7C MN Matrix metalloproteinase-3 (MMP-3) DMFBP7C MT DTT DMFBP7C MA Inhibitor DMFBP7C RN Inhibition of metalloproteinase by futoenone derivatives, Bioorg. Med. Chem. Lett. 5(15):1637-1642 (1995). DMFBP7C RU http://www.sciencedirect.com/science/article/pii/0960894X9500282X DMEI890 DI DMEI890 DMEI890 DN FV-Aib-TDVGPFAF DMEI890 MI TTVSFJW DMEI890 MN Calcitonin gene-related peptide 1 (CALCA) DMEI890 MT DTT DMEI890 MA Inhibitor DMEI890 RN Identification of potent, selective, and metabolically stable peptide antagonists to the calcitonin gene-related peptide (CGRP) receptor. J Med Chem. 2008 Dec 25;51(24):7889-97. DMEI890 RU https://pubmed.ncbi.nlm.nih.gov/19053766 DMEI890 DI DMEI890 DMEI890 DN FV-Aib-TDVGPFAF DMEI890 MI TTY6O0Q DMEI890 MN Calcitonin gene-related peptide receptor (CGRPR) DMEI890 MT DTT DMEI890 MA Inhibitor DMEI890 RN Identification of the key residue of calcitonin gene related peptide (CGRP) 27-37 to obtain antagonists with picomolar affinity at the CGRP receptor. J Med Chem. 2006 Jan 26;49(2):616-24. DMEI890 RU https://pubmed.ncbi.nlm.nih.gov/16420047 DMDG1ZX DI DMDG1ZX DMDG1ZX DN FVATDVGPFAF DMDG1ZX MI TTY6O0Q DMDG1ZX MN Calcitonin gene-related peptide receptor (CGRPR) DMDG1ZX MT DTT DMDG1ZX MA Inhibitor DMDG1ZX RN Identification of the key residue of calcitonin gene related peptide (CGRP) 27-37 to obtain antagonists with picomolar affinity at the CGRP receptor. J Med Chem. 2006 Jan 26;49(2):616-24. DMDG1ZX RU https://pubmed.ncbi.nlm.nih.gov/16420047 DMXQC6H DI DMXQC6H DMXQC6H DN FV-Hyp-TDVGPFAF DMXQC6H MI TTY6O0Q DMXQC6H MN Calcitonin gene-related peptide receptor (CGRPR) DMXQC6H MT DTT DMXQC6H MA Inhibitor DMXQC6H RN Identification of the key residue of calcitonin gene related peptide (CGRP) 27-37 to obtain antagonists with picomolar affinity at the CGRP receptor. J Med Chem. 2006 Jan 26;49(2):616-24. DMXQC6H RU https://pubmed.ncbi.nlm.nih.gov/16420047 DMSD7B1 DI DMSD7B1 DMSD7B1 DN FVPTDVGAFAF DMSD7B1 MI TTY6O0Q DMSD7B1 MN Calcitonin gene-related peptide receptor (CGRPR) DMSD7B1 MT DTT DMSD7B1 MA Inhibitor DMSD7B1 RN Identification of the key residue of calcitonin gene related peptide (CGRP) 27-37 to obtain antagonists with picomolar affinity at the CGRP receptor. J Med Chem. 2006 Jan 26;49(2):616-24. DMSD7B1 RU https://pubmed.ncbi.nlm.nih.gov/16420047 DMUVXZQ DI DMUVXZQ DMUVXZQ DN FVPTDVGPFAF DMUVXZQ MI TTY6O0Q DMUVXZQ MN Calcitonin gene-related peptide receptor (CGRPR) DMUVXZQ MT DTT DMUVXZQ MA Inhibitor DMUVXZQ RN Identification of the key residue of calcitonin gene related peptide (CGRP) 27-37 to obtain antagonists with picomolar affinity at the CGRP receptor. J Med Chem. 2006 Jan 26;49(2):616-24. DMUVXZQ RU https://pubmed.ncbi.nlm.nih.gov/16420047 DM58JFR DI DM58JFR DM58JFR DN FVPTDVG-Tic-FAF-Tic DM58JFR MI TTY6O0Q DM58JFR MN Calcitonin gene-related peptide receptor (CGRPR) DM58JFR MT DTT DM58JFR MA Inhibitor DM58JFR RN Identification of the key residue of calcitonin gene related peptide (CGRP) 27-37 to obtain antagonists with picomolar affinity at the CGRP receptor. J Med Chem. 2006 Jan 26;49(2):616-24. DM58JFR RU https://pubmed.ncbi.nlm.nih.gov/16420047 DMBOE1U DI DMBOE1U DMBOE1U DN FV-Tic-TDVGPFAF DMBOE1U MI TTY6O0Q DMBOE1U MN Calcitonin gene-related peptide receptor (CGRPR) DMBOE1U MT DTT DMBOE1U MA Inhibitor DMBOE1U RN Identification of the key residue of calcitonin gene related peptide (CGRP) 27-37 to obtain antagonists with picomolar affinity at the CGRP receptor. J Med Chem. 2006 Jan 26;49(2):616-24. DMBOE1U RU https://pubmed.ncbi.nlm.nih.gov/16420047 DMAZ1NW DI DMAZ1NW DMAZ1NW DN FXI-AS1 DMAZ1NW MI TTDM4ZU DMAZ1NW MN Factor XI messenger RNA (F11 mRNA) DMAZ1NW MT DTT DMAZ1NW RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2360). DMAZ1NW RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2360 DMUC0F5 DI DMUC0F5 DMUC0F5 DN G(D-Pen)-G-H-R-G-D-L-R-C-A DMUC0F5 MI TTT1R2L DMUC0F5 MN Integrin alpha-V (ITGAV) DMUC0F5 MT DTT DMUC0F5 MA Inhibitor DMUC0F5 RN Design and synthesis of novel cyclic RGD-containing peptides as highly potent and selective integrin alpha IIb beta 3 antagonists. J Med Chem. 1994 Jan 7;37(1):1-8. DMUC0F5 RU https://pubmed.ncbi.nlm.nih.gov/7507165 DMXZGKI DI DMXZGKI DMXZGKI DN G009 DMXZGKI MI TTV0YFR DMXZGKI MN Lipid peroxidation (LPO) DMXZGKI MT DTT DMXZGKI MA Inhibitor DMXZGKI RN Inhibition of lipid peroxidation and oxidative DNA damage by Ganoderma lucidum. Phytother Res. 2001 May;15(3):245-9. DMXZGKI RU https://pubmed.ncbi.nlm.nih.gov/11351361 DMMEC9D DI DMMEC9D DMMEC9D DN G15 DMMEC9D MI TTDSB34 DMMEC9D MN G-protein coupled estrogen receptor 1 (GPER1) DMMEC9D MT DTT DMMEC9D MA Antagonist DMMEC9D RN In vivo effects of a GPR30 antagonist. Nat Chem Biol. 2009 Jun;5(6):421-7. DMMEC9D RU https://pubmed.ncbi.nlm.nih.gov/19430488 DMADOK6 DI DMADOK6 DMADOK6 DN G-25 DMADOK6 MI TTCS8WB DMADOK6 MN Plasmodium Choline transporter (Malaria CT) DMADOK6 MT DTT DMADOK6 MA Blocker DMADOK6 RN Novel molecular targets for antimalarial drug development. Chem Biol Drug Des. 2008 Apr;71(4):287-97. DMADOK6 RU https://pubmed.ncbi.nlm.nih.gov/18298458 DM3ZBGQ DI DM3ZBGQ DM3ZBGQ DN G3139 + cytarabine (ARA-C) DM3ZBGQ MI TTFOUV4 DM3ZBGQ MN BCL-2 messenger RNA (BCL2 mRNA) DM3ZBGQ MT DTT DM3ZBGQ RN Design and development of antisense drugs. Expert Opin. Drug Discov. 2008 3(10):1189-1207. DM3ZBGQ RU http://www.informahealthcare.com/doi/abs/10.1517/17460441.3.10.1177 DMFJ1EI DI DMFJ1EI DMFJ1EI DN G3139 + Dacarbazine DMFJ1EI MI TTFOUV4 DMFJ1EI MN BCL-2 messenger RNA (BCL2 mRNA) DMFJ1EI MT DTT DMFJ1EI RN Design and development of antisense drugs. Expert Opin. Drug Discov. 2008 3(10):1189-1207. DMFJ1EI RU http://www.informahealthcare.com/doi/abs/10.1517/17460441.3.10.1177 DMJ9DN3 DI DMJ9DN3 DMJ9DN3 DN G3139 + Dexamethasone DMJ9DN3 MI TTFOUV4 DMJ9DN3 MN BCL-2 messenger RNA (BCL2 mRNA) DMJ9DN3 MT DTT DMJ9DN3 RN Design and development of antisense drugs. Expert Opin. Drug Discov. 2008 3(10):1189-1207. DMJ9DN3 RU http://www.informahealthcare.com/doi/abs/10.1517/17460441.3.10.1177 DMRVLZ4 DI DMRVLZ4 DMRVLZ4 DN G3139 + Fludarabine DMRVLZ4 MI TTFOUV4 DMRVLZ4 MN BCL-2 messenger RNA (BCL2 mRNA) DMRVLZ4 MT DTT DMRVLZ4 RN Design and development of antisense drugs. Expert Opin. Drug Discov. 2008 3(10):1189-1207. DMRVLZ4 RU http://www.informahealthcare.com/doi/abs/10.1517/17460441.3.10.1177 DMH6UOL DI DMH6UOL DMH6UOL DN G3139 + G-CSF DMH6UOL MI TTFOUV4 DMH6UOL MN BCL-2 messenger RNA (BCL2 mRNA) DMH6UOL MT DTT DMH6UOL RN Design and development of antisense drugs. Expert Opin. Drug Discov. 2008 3(10):1189-1207. DMH6UOL RU http://www.informahealthcare.com/doi/abs/10.1517/17460441.3.10.1177 DMZLJ21 DI DMZLJ21 DMZLJ21 DN G3139 + Irinotecan DMZLJ21 MI TTFOUV4 DMZLJ21 MN BCL-2 messenger RNA (BCL2 mRNA) DMZLJ21 MT DTT DMZLJ21 RN Design and development of antisense drugs. Expert Opin. Drug Discov. 2008 3(10):1189-1207. DMZLJ21 RU http://www.informahealthcare.com/doi/abs/10.1517/17460441.3.10.1177 DM3MK9Z DI DM3MK9Z DM3MK9Z DN G3139 + Paclitaxel DM3MK9Z MI TTFOUV4 DM3MK9Z MN BCL-2 messenger RNA (BCL2 mRNA) DM3MK9Z MT DTT DM3MK9Z RN Design and development of antisense drugs. Expert Opin. Drug Discov. 2008 3(10):1189-1207. DM3MK9Z RU http://www.informahealthcare.com/doi/abs/10.1517/17460441.3.10.1177 DM5KO80 DI DM5KO80 DM5KO80 DN G3139 + Thalidomide DM5KO80 MI TTFOUV4 DM5KO80 MN BCL-2 messenger RNA (BCL2 mRNA) DM5KO80 MT DTT DM5KO80 RN Design and development of antisense drugs. Expert Opin. Drug Discov. 2008 3(10):1189-1207. DM5KO80 RU http://www.informahealthcare.com/doi/abs/10.1517/17460441.3.10.1177 DMDJCIP DI DMDJCIP DMDJCIP DN G36 DMDJCIP MI TTDSB34 DMDJCIP MN G-protein coupled estrogen receptor 1 (GPER1) DMDJCIP MT DTT DMDJCIP MA Antagonist DMDJCIP RN Identification of a GPER/GPR30 antagonist with improved estrogen receptor counterselectivity. J Steroid Biochem Mol Biol. 2011 Nov;127(3-5):358-66. DMDJCIP RU https://pubmed.ncbi.nlm.nih.gov/21782022 DMKTJBU DI DMKTJBU DMKTJBU DN G418 DMKTJBU MI TT38DW5 DMKTJBU MN Bacterial 16S ribosomal RNA (Bact 16S rRNA) DMKTJBU MT DTT DMKTJBU MA Inhibitor DMKTJBU RN RNA as a target for small molecules. Curr Opin Chem Biol. 2000 Dec;4(6):678-86. DMKTJBU RU https://pubmed.ncbi.nlm.nih.gov/11102874 DMKTJBU DI DMKTJBU DMKTJBU DN G418 DMKTJBU MI TTUMGNO DMKTJBU MN Ornithine decarboxylase (ODC1) DMKTJBU MT DTT DMKTJBU MA Inhibitor DMKTJBU RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMKTJBU RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMKTJBU DI DMKTJBU DMKTJBU DN G418 DMKTJBU MI DTUGYRD DMKTJBU MN P-glycoprotein 1 (ABCB1) DMKTJBU MT DTP DMKTJBU MA Substrate DMKTJBU RN ATP-binding cassette transporters as pitfalls in selection of transgenic cells. Anal Biochem. 2010 Apr 15;399(2):246-50. DMKTJBU RU https://doi.org/10.1016/j.ab.2009.12.014 DMC54UG DI DMC54UG DMC54UG DN G-573 DMC54UG MI TTROQ37 DMC54UG MN MAPK/ERK kinase kinase (MAP3K) DMC54UG MT DTT DMC54UG MA Inhibitor DMC54UG RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2063). DMC54UG RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2063 DMEZO4M DI DMEZO4M DMEZO4M DN G6976 DMEZO4M MI TTSXVID DMEZO4M MN Nuclear factor NF-kappa-B (NFKB) DMEZO4M MT DTT DMEZO4M MA Inhibitor DMEZO4M RN Epidermal growth factor-induced nuclear factor kappa B activation: A major pathway of cell-cycle progression in estrogen-receptor negative breast cancer cells. Proc Natl Acad Sci U S A. 2000 Jul 18;97(15):8542-7. DMEZO4M RU https://pubmed.ncbi.nlm.nih.gov/10900013 DMEZO4M DI DMEZO4M DMEZO4M DN G6976 DMEZO4M MI TTYVX59 DMEZO4M MN Protein kinase C (PRKC) DMEZO4M MT DTT DMEZO4M MA Inhibitor DMEZO4M RN The protein kinase C inhibitor G 6976 is a potent inhibitor of DNA damage-induced S and G2 cell cycle checkpoints. Cancer Res. 2003 Jan 1;63(1):31-5. DMEZO4M RU https://pubmed.ncbi.nlm.nih.gov/12517773 DMEZO4M DI DMEZO4M DMEZO4M DN G6976 DMEZO4M MI TTUWGRA DMEZO4M MN Protein kinase C zeta (PRKCZ) DMEZO4M MT DTT DMEZO4M MA Inhibitor DMEZO4M RN Protein kinase C zeta isoform is critical for proliferation in human glioblastoma cell lines. J Neurooncol. 2000 Apr;47(2):109-15. DMEZO4M RU https://pubmed.ncbi.nlm.nih.gov/10982151 DMEZO4M DI DMEZO4M DMEZO4M DN G6976 DMEZO4M MI TTSLUMT DMEZO4M MN Protein kinase D (PRKD1) DMEZO4M MT DTT DMEZO4M MA Inhibitor DMEZO4M RN Protein kinase D as a potential new target for cancer therapy. Biochim Biophys Acta. 2010 Dec;1806(2):183-92. DMEZO4M RU https://pubmed.ncbi.nlm.nih.gov/20580776 DMC7HIS DI DMC7HIS DMC7HIS DN G749 DMC7HIS MI TTGJCWZ DMC7HIS MN Fms-like tyrosine kinase 3 (FLT-3) DMC7HIS MT DTT DMC7HIS MA Inhibitor DMC7HIS RN G-749, a novel FLT3 kinase inhibitor, can overcome drug resistance for the treatment of acute myeloid leukemia. Blood. 2014 Apr 3;123(14):2209-19. DMC7HIS RU https://pubmed.ncbi.nlm.nih.gov/24532805 DMC7HIS DI DMC7HIS DMC7HIS DN G749 DMC7HIS MI TTO7LKR DMC7HIS MN Tyrosine-protein kinase Mer (MERTK) DMC7HIS MT DTT DMC7HIS MA Inhibitor DMC7HIS RN G-749, a novel FLT3 kinase inhibitor, can overcome drug resistance for the treatment of acute myeloid leukemia. Blood. 2014 Apr 3;123(14):2209-19. DMC7HIS RU https://pubmed.ncbi.nlm.nih.gov/24532805 DMOF7JL DI DMOF7JL DMOF7JL DN GABA-B receptor PAM DMOF7JL MI TTDCVZW DMOF7JL MN Gamma-aminobutyric acid B receptor (GABBR) DMOF7JL MT DTT DMOF7JL MA Modulator DMOF7JL RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 241). DMOF7JL RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=241 DMDEAWS DI DMDEAWS DMDEAWS DN Gababutin DMDEAWS MI TTFK1JQ DMDEAWS MN Voltage-gated calcium channel alpha-2/delta-1 (CACNA2D1) DMDEAWS MT DTT DMDEAWS MA Inhibitor DMDEAWS RN Synthesis and in vivo evaluation of 3-substituted gababutins. Bioorg Med Chem Lett. 2010 Jan 1;20(1):362-5. DMDEAWS RU https://pubmed.ncbi.nlm.nih.gov/19897364 DMH17MU DI DMH17MU DMH17MU DN Gabaculine DMH17MU MI TT6LDTK DMH17MU MN Bacterial Glutamate-1-semialdehyde aminomutase (Bact hemL) DMH17MU MT DTT DMH17MU MA Inhibitor DMH17MU RN A suicide vector for allelic recombination involving the gene for glutamate 1-semialdehyde aminotransferase in the cyanobacterium Synechococcus PCC 7942. Mol Gen Genet. 1997 Jul;255(4):392-9. DMH17MU RU https://pubmed.ncbi.nlm.nih.gov/9267435 DM5TQ2O DI DM5TQ2O DM5TQ2O DN Galangin DM5TQ2O MI TTM2AOE DM5TQ2O MN Adenosine A2a receptor (ADORA2A) DM5TQ2O MT DTT DM5TQ2O MA Inhibitor DM5TQ2O RN Mutagenesis reveals structure-activity parallels between human A2A adenosine receptors and biogenic amine G protein-coupled receptors. J Med Chem. 1997 Aug 1;40(16):2588-95. DM5TQ2O RU https://pubmed.ncbi.nlm.nih.gov/9258366 DM5TQ2O DI DM5TQ2O DM5TQ2O DN Galangin DM5TQ2O MI TTJFY5U DM5TQ2O MN Adenosine A3 receptor (ADORA3) DM5TQ2O MT DTT DM5TQ2O MA Inhibitor DM5TQ2O RN Interactions of flavonoids and other phytochemicals with adenosine receptors. J Med Chem. 1996 Feb 2;39(3):781-8. DM5TQ2O RU https://pubmed.ncbi.nlm.nih.gov/8576921 DM5TQ2O DI DM5TQ2O DM5TQ2O DN Galangin DM5TQ2O MI TTI84H7 DM5TQ2O MN Cytochrome P450 1B1 (CYP1B1) DM5TQ2O MT DTT DM5TQ2O MA Inhibitor DM5TQ2O RN Selective inhibition of methoxyflavonoids on human CYP1B1 activity. Bioorg Med Chem. 2010 Sep 1;18(17):6310-5. DM5TQ2O RU https://pubmed.ncbi.nlm.nih.gov/20696580 DMHPV8A DI DMHPV8A DMHPV8A DN GALANIN DMHPV8A MI TTX3HNZ DMHPV8A MN Galanin receptor type 1 (GAL1-R) DMHPV8A MT DTT DMHPV8A MA Inhibitor DMHPV8A RN cis-4-(Piperazin-1-yl)-5,6,7a,8,9,10,11,11a-octahydrobenzofuro[2,3-h]quinazolin-2-amine (A-987306), a new histamine H4R antagonist that blocks pain... J Med Chem. 2008 Nov 27;51(22):7094-8. DMHPV8A RU https://pubmed.ncbi.nlm.nih.gov/18983139 DMHPV8A DI DMHPV8A DMHPV8A DN GALANIN DMHPV8A MI TTBPW3J DMHPV8A MN Galanin receptor type 2 (GAL2-R) DMHPV8A MT DTT DMHPV8A MA Inhibitor DMHPV8A RN Identification of a potent, selective, and orally active leukotriene a4 hydrolase inhibitor with anti-inflammatory activity. J Med Chem. 2008 Jul 24;51(14):4150-69. DMHPV8A RU https://pubmed.ncbi.nlm.nih.gov/18588282 DMAFE24 DI DMAFE24 DMAFE24 DN Galanthamine derivative DMAFE24 MI TT1RS9F DMAFE24 MN Acetylcholinesterase (AChE) DMAFE24 MT DTT DMAFE24 MA Inhibitor DMAFE24 RN Exploiting protein fluctuations at the active-site gorge of human cholinesterases: further optimization of the design strategy to develop extremely... J Med Chem. 2008 Jun 12;51(11):3154-70. DMAFE24 RU https://pubmed.ncbi.nlm.nih.gov/18479118 DMDZHEO DI DMDZHEO DMDZHEO DN GALANTIDE DMDZHEO MI TTX3HNZ DMDZHEO MN Galanin receptor type 1 (GAL1-R) DMDZHEO MT DTT DMDZHEO MA Inhibitor DMDZHEO RN Engineering galanin analogues that discriminate between GalR1 and GalR2 receptor subtypes and exhibit anticonvulsant activity following systemic de... J Med Chem. 2010 Feb 25;53(4):1871-5. DMDZHEO RU https://pubmed.ncbi.nlm.nih.gov/20121116 DMDZHEO DI DMDZHEO DMDZHEO DN GALANTIDE DMDZHEO MI TTBPW3J DMDZHEO MN Galanin receptor type 2 (GAL2-R) DMDZHEO MT DTT DMDZHEO MA Inhibitor DMDZHEO RN Engineering galanin analogues that discriminate between GalR1 and GalR2 receptor subtypes and exhibit anticonvulsant activity following systemic de... J Med Chem. 2010 Feb 25;53(4):1871-5. DMDZHEO RU https://pubmed.ncbi.nlm.nih.gov/20121116 DMGX6UH DI DMGX6UH DMGX6UH DN GalB2 DMGX6UH MI TTX3HNZ DMGX6UH MN Galanin receptor type 1 (GAL1-R) DMGX6UH MT DTT DMGX6UH MA Inhibitor DMGX6UH RN Engineering galanin analogues that discriminate between GalR1 and GalR2 receptor subtypes and exhibit anticonvulsant activity following systemic de... J Med Chem. 2010 Feb 25;53(4):1871-5. DMGX6UH RU https://pubmed.ncbi.nlm.nih.gov/20121116 DMGX6UH DI DMGX6UH DMGX6UH DN GalB2 DMGX6UH MI TTBPW3J DMGX6UH MN Galanin receptor type 2 (GAL2-R) DMGX6UH MT DTT DMGX6UH MA Inhibitor DMGX6UH RN Engineering galanin analogues that discriminate between GalR1 and GalR2 receptor subtypes and exhibit anticonvulsant activity following systemic de... J Med Chem. 2010 Feb 25;53(4):1871-5. DMGX6UH RU https://pubmed.ncbi.nlm.nih.gov/20121116 DM7PR5E DI DM7PR5E DM7PR5E DN Gal-B5 DM7PR5E MI TTX3HNZ DM7PR5E MN Galanin receptor type 1 (GAL1-R) DM7PR5E MT DTT DM7PR5E MA Inhibitor DM7PR5E RN Engineering galanin analogues that discriminate between GalR1 and GalR2 receptor subtypes and exhibit anticonvulsant activity following systemic de... J Med Chem. 2010 Feb 25;53(4):1871-5. DM7PR5E RU https://pubmed.ncbi.nlm.nih.gov/20121116 DM7PR5E DI DM7PR5E DM7PR5E DN Gal-B5 DM7PR5E MI TTBPW3J DM7PR5E MN Galanin receptor type 2 (GAL2-R) DM7PR5E MT DTT DM7PR5E MA Inhibitor DM7PR5E RN Engineering galanin analogues that discriminate between GalR1 and GalR2 receptor subtypes and exhibit anticonvulsant activity following systemic de... J Med Chem. 2010 Feb 25;53(4):1871-5. DM7PR5E RU https://pubmed.ncbi.nlm.nih.gov/20121116 DMNWU83 DI DMNWU83 DMNWU83 DN Gallic acid 5,6-dihydroxy-3-carboxyphenylester DMNWU83 MI TTIU7X1 DMNWU83 MN Herpes simplex virus DNA polymerase UL30 (HSV UL30) DMNWU83 MT DTT DMNWU83 MA Inhibitor DMNWU83 RN Differential inhibition of reverse transcriptase and various DNA polymerases by digallic acid and its derivatives. J Nat Prod. 1990 Sep-Oct;53(5):1234-40. DMNWU83 RU https://pubmed.ncbi.nlm.nih.gov/1705574 DM6Y3A0 DI DM6Y3A0 DM6Y3A0 DN GALLICACID DM6Y3A0 MI TTUNARX DM6Y3A0 MN Carbonic anhydrase (CA) DM6Y3A0 MT DTT DM6Y3A0 MA Inhibitor DM6Y3A0 RN Carbonic anhydrase inhibitors. Inhibition of mammalian isoforms I-XIV with a series of natural product polyphenols and phenolic acids. Bioorg Med Chem. 2010 Mar 15;18(6):2159-2164. DM6Y3A0 RU https://pubmed.ncbi.nlm.nih.gov/20185318 DM6Y3A0 DI DM6Y3A0 DM6Y3A0 DN GALLICACID DM6Y3A0 MI TTHQPL7 DM6Y3A0 MN Carbonic anhydrase I (CA-I) DM6Y3A0 MT DTT DM6Y3A0 MA Inhibitor DM6Y3A0 RN Carbonic anhydrase inhibitors. Inhibition of mammalian isoforms I-XIV with a series of natural product polyphenols and phenolic acids. Bioorg Med Chem. 2010 Mar 15;18(6):2159-2164. DM6Y3A0 RU https://pubmed.ncbi.nlm.nih.gov/20185318 DM6Y3A0 DI DM6Y3A0 DM6Y3A0 DN GALLICACID DM6Y3A0 MI TTANPDJ DM6Y3A0 MN Carbonic anhydrase II (CA-II) DM6Y3A0 MT DTT DM6Y3A0 MA Inhibitor DM6Y3A0 RN Carbonic anhydrase inhibitors. Inhibition of mammalian isoforms I-XIV with a series of natural product polyphenols and phenolic acids. Bioorg Med Chem. 2010 Mar 15;18(6):2159-2164. DM6Y3A0 RU https://pubmed.ncbi.nlm.nih.gov/20185318 DM6Y3A0 DI DM6Y3A0 DM6Y3A0 DN GALLICACID DM6Y3A0 MI TTZHA0O DM6Y3A0 MN Carbonic anhydrase IV (CA-IV) DM6Y3A0 MT DTT DM6Y3A0 MA Inhibitor DM6Y3A0 RN Carbonic anhydrase inhibitors. Inhibition of mammalian isoforms I-XIV with a series of natural product polyphenols and phenolic acids. Bioorg Med Chem. 2010 Mar 15;18(6):2159-2164. DM6Y3A0 RU https://pubmed.ncbi.nlm.nih.gov/20185318 DM6Y3A0 DI DM6Y3A0 DM6Y3A0 DN GALLICACID DM6Y3A0 MI TT2LVK8 DM6Y3A0 MN Carbonic anhydrase IX (CA-IX) DM6Y3A0 MT DTT DM6Y3A0 MA Inhibitor DM6Y3A0 RN Carbonic anhydrase inhibitors. Inhibition of mammalian isoforms I-XIV with a series of natural product polyphenols and phenolic acids. Bioorg Med Chem. 2010 Mar 15;18(6):2159-2164. DM6Y3A0 RU https://pubmed.ncbi.nlm.nih.gov/20185318 DM6Y3A0 DI DM6Y3A0 DM6Y3A0 DN GALLICACID DM6Y3A0 MI TTCFSPE DM6Y3A0 MN Carbonic anhydrase VI (CA-VI) DM6Y3A0 MT DTT DM6Y3A0 MA Inhibitor DM6Y3A0 RN Carbonic anhydrase inhibitors. Inhibition of mammalian isoforms I-XIV with a series of natural product polyphenols and phenolic acids. Bioorg Med Chem. 2010 Mar 15;18(6):2159-2164. DM6Y3A0 RU https://pubmed.ncbi.nlm.nih.gov/20185318 DM6Y3A0 DI DM6Y3A0 DM6Y3A0 DN GALLICACID DM6Y3A0 MI TTSYM0R DM6Y3A0 MN Carbonic anhydrase XII (CA-XII) DM6Y3A0 MT DTT DM6Y3A0 MA Inhibitor DM6Y3A0 RN Carbonic anhydrase inhibitors. Inhibition of mammalian isoforms I-XIV with a series of natural product polyphenols and phenolic acids. Bioorg Med Chem. 2010 Mar 15;18(6):2159-2164. DM6Y3A0 RU https://pubmed.ncbi.nlm.nih.gov/20185318 DM6Y3A0 DI DM6Y3A0 DM6Y3A0 DN GALLICACID DM6Y3A0 MI TTEYTKG DM6Y3A0 MN Carbonic anhydrase XIV (CA-XIV) DM6Y3A0 MT DTT DM6Y3A0 MA Inhibitor DM6Y3A0 RN Carbonic anhydrase inhibitors. Inhibition of mammalian isoforms I-XIV with a series of natural product polyphenols and phenolic acids. Bioorg Med Chem. 2010 Mar 15;18(6):2159-2164. DM6Y3A0 RU https://pubmed.ncbi.nlm.nih.gov/20185318 DM6Y3A0 DI DM6Y3A0 DM6Y3A0 DN GALLICACID DM6Y3A0 MI TTE5VG0 DM6Y3A0 MN P-selectin (SELP) DM6Y3A0 MT DTT DM6Y3A0 MA Inhibitor DM6Y3A0 RN Rational design of novel, potent small molecule pan-selectin antagonists. J Med Chem. 2007 Mar 22;50(6):1101-15. DM6Y3A0 RU https://pubmed.ncbi.nlm.nih.gov/17302397 DMX2084 DI DMX2084 DMX2084 DN GALLOCATECHIN GALLATE DMX2084 MI TT7AOUD DMX2084 MN Fatty acid synthase (FASN) DMX2084 MT DTT DMX2084 MA Inhibitor DMX2084 RN Inhibition of Plasmodium falciparum fatty acid biosynthesis: evaluation of FabG, FabZ, and FabI as drug targets for flavonoids. J Med Chem. 2006 Jun 1;49(11):3345-53. DMX2084 RU https://pubmed.ncbi.nlm.nih.gov/16722653 DMX2084 DI DMX2084 DMX2084 DN GALLOCATECHIN GALLATE DMX2084 MI TTHPFTS DMX2084 MN Plasmodium Beta-hydroxyacyl-ACP dehydratase (Malaria FabZ) DMX2084 MT DTT DMX2084 MA Inhibitor DMX2084 RN Inhibition of Plasmodium falciparum fatty acid biosynthesis: evaluation of FabG, FabZ, and FabI as drug targets for flavonoids. J Med Chem. 2006 Jun 1;49(11):3345-53. DMX2084 RU https://pubmed.ncbi.nlm.nih.gov/16722653 DMX2084 DI DMX2084 DMX2084 DN GALLOCATECHIN GALLATE DMX2084 MI TTNX2CS DMX2084 MN Plasmodium Enoyl-ACP reductase (Malaria fabI) DMX2084 MT DTT DMX2084 MA Inhibitor DMX2084 RN Inhibition of Plasmodium falciparum fatty acid biosynthesis: evaluation of FabG, FabZ, and FabI as drug targets for flavonoids. J Med Chem. 2006 Jun 1;49(11):3345-53. DMX2084 RU https://pubmed.ncbi.nlm.nih.gov/16722653 DMX2084 DI DMX2084 DMX2084 DN GALLOCATECHIN GALLATE DMX2084 MI TTBE4IR DMX2084 MN Plasmodium Oxoacyl-[acyl-carrier protein] reductase (Malaria fabG) DMX2084 MT DTT DMX2084 MA Inhibitor DMX2084 RN Inhibition of Plasmodium falciparum fatty acid biosynthesis: evaluation of FabG, FabZ, and FabI as drug targets for flavonoids. J Med Chem. 2006 Jun 1;49(11):3345-53. DMX2084 RU https://pubmed.ncbi.nlm.nih.gov/16722653 DML9DH8 DI DML9DH8 DML9DH8 DN galmic DML9DH8 MI TTOPAY7 DML9DH8 MN Galanin receptor (GAL-R) DML9DH8 MT DTT DML9DH8 MA Agonist DML9DH8 RN Galmic, a nonpeptide galanin receptor agonist, affects behaviors in seizure, pain, and forced-swim tests. Proc Natl Acad Sci U S A. 2004 Jul 13;101(28):10470-5. DML9DH8 RU https://pubmed.ncbi.nlm.nih.gov/15240875 DMB8HCW DI DMB8HCW DMB8HCW DN Galnon DMB8HCW MI TTX3HNZ DMB8HCW MN Galanin receptor type 1 (GAL1-R) DMB8HCW MT DTT DMB8HCW MA Agonist DMB8HCW RN Anticonvulsant activity of a nonpeptide galanin receptor agonist. Proc Natl Acad Sci U S A. 2002 May 14;99(10):7136-41. DMB8HCW RU https://pubmed.ncbi.nlm.nih.gov/12011470 DMI7RPT DI DMI7RPT DMI7RPT DN GalR3ant DMI7RPT MI TTOPAY7 DMI7RPT MN Galanin receptor (GAL-R) DMI7RPT MT DTT DMI7RPT MA Antagonist DMI7RPT RN Galanin (2-11) binds to GalR3 in transfected cell lines: limitations for pharmacological definition of receptor subtypes. Neuropeptides. 2005 Jun;39(3):165-7. DMI7RPT RU https://pubmed.ncbi.nlm.nih.gov/15944007 DMFSXOM DI DMFSXOM DMFSXOM DN Gamma-acetylenic GABA DMFSXOM MI TTT2LD9 DMFSXOM MN GABA transaminase (ABAT) DMFSXOM MT DTT DMFSXOM MA Inhibitor DMFSXOM RN Treatment of Huntington disease with gamma-acetylenic GABA an irreversible inhibitor of GABA-transaminase: increased CSF GABA and homocarnosine without clinical amelioration. Neurology. 1981 Feb;31(2):207-11. DMFSXOM RU https://pubmed.ncbi.nlm.nih.gov/6258106 DMDCZWY DI DMDCZWY DMDCZWY DN Gamma-butyrolactone DMDCZWY MI DESDN74 DMDCZWY MN Serum paraoxonase/arylesterase 1 (PON1) DMDCZWY MT DME DMDCZWY MA Metabolism DMDCZWY RN Human serum paraoxonase (PON1) isozymes Q and R hydrolyze lactones and cyclic carbonate esters. Drug Metab Dispos. 2000 Nov;28(11):1335-42. DMDCZWY RU https://www.ncbi.nlm.nih.gov/pubmed/?term=11038162 DMZMCT0 DI DMZMCT0 DMZMCT0 DN Gamma-Carboxy-Glutamic Acid DMZMCT0 MI TT6L509 DMZMCT0 MN Coagulation factor IIa (F2) DMZMCT0 MT DTT DMZMCT0 MA Inhibitor DMZMCT0 RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMZMCT0 RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMZMCT0 DI DMZMCT0 DMZMCT0 DN Gamma-Carboxy-Glutamic Acid DMZMCT0 MI TTFEZ5Q DMZMCT0 MN Coagulation factor IX (F9) DMZMCT0 MT DTT DMZMCT0 MA Inhibitor DMZMCT0 RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMZMCT0 RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMZMCT0 DI DMZMCT0 DMZMCT0 DN Gamma-Carboxy-Glutamic Acid DMZMCT0 MI TTCIHJA DMZMCT0 MN Coagulation factor Xa (F10) DMZMCT0 MT DTT DMZMCT0 MA Inhibitor DMZMCT0 RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMZMCT0 RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMHNJDE DI DMHNJDE DMHNJDE DN Gamma-Glutamyl[S-(2-Iodobenzyl)Cysteinyl]Glycine DMHNJDE MI TTJ0IQB DMHNJDE MN Phosphodiesterase 5A (PDE5A) DMHNJDE MT DTT DMHNJDE MA Inhibitor DMHNJDE RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMHNJDE RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMC0OVP DI DMC0OVP DMC0OVP DN Gamma-mangostin DMC0OVP MI TTSZLWK DMC0OVP MN Aromatase (CYP19A1) DMC0OVP MT DTT DMC0OVP MA Inhibitor DMC0OVP RN Xanthones from the botanical dietary supplement mangosteen (Garcinia mangostana) with aromatase inhibitory activity. J Nat Prod. 2008 Jul;71(7):1161-6. DMC0OVP RU https://pubmed.ncbi.nlm.nih.gov/18558747 DMC0OVP DI DMC0OVP DMC0OVP DN Gamma-mangostin DMC0OVP MI TT50QJ3 DMC0OVP MN Influenza Neuraminidase (Influ NA) DMC0OVP MT DTT DMC0OVP MA Inhibitor DMC0OVP RN Xanthones with neuraminidase inhibitory activity from the seedcases of Garcinia mangostana. Bioorg Med Chem. 2010 Sep 1;18(17):6258-64. DMC0OVP RU https://pubmed.ncbi.nlm.nih.gov/20696581 DMG7UPR DI DMG7UPR DMG7UPR DN Gamma-secretase modulators DMG7UPR MI TTE4KHA DMG7UPR MN Amyloid beta A4 protein (APP) DMG7UPR MT DTT DMG7UPR MA Modulator DMG7UPR RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2402). DMG7UPR RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2402 DM83HUI DI DM83HUI DM83HUI DN Gamma-thiobutyrolactone DM83HUI MI DESDN74 DM83HUI MN Serum paraoxonase/arylesterase 1 (PON1) DM83HUI MT DME DM83HUI MA Metabolism DM83HUI RN Human serum paraoxonase (PON1) isozymes Q and R hydrolyze lactones and cyclic carbonate esters. Drug Metab Dispos. 2000 Nov;28(11):1335-42. DM83HUI RU https://www.ncbi.nlm.nih.gov/pubmed/?term=11038162 DM42EVG DI DM42EVG DM42EVG DN Ganoderic acid A DM42EVG MI TT9H85R DM42EVG MN Corticosteroid 11-beta-dehydrogenase 2 (HSD11B2) DM42EVG MT DTT DM42EVG MA Inhibitor DM42EVG RN 11beta-Hydroxysteroid dehydrogenase 1 inhibiting constituents from Eriobotrya japonica revealed by bioactivity-guided isolation and computational a... Bioorg Med Chem. 2010 Feb 15;18(4):1507-15. DM42EVG RU https://pubmed.ncbi.nlm.nih.gov/20100662 DMFT4GU DI DMFT4GU DMFT4GU DN GANSTIGMINE DMFT4GU MI TT1RS9F DMFT4GU MN Acetylcholinesterase (AChE) DMFT4GU MT DTT DMFT4GU MA Inhibitor DMFT4GU RN Exploiting protein fluctuations at the active-site gorge of human cholinesterases: further optimization of the design strategy to develop extremely... J Med Chem. 2008 Jun 12;51(11):3154-70. DMFT4GU RU https://pubmed.ncbi.nlm.nih.gov/18479118 DM6B9ZG DI DM6B9ZG DM6B9ZG DN garcinol DM6B9ZG MI TTVK7SB DM6B9ZG MN Histone acetyltransferase KAT2B (KAT2B) DM6B9ZG MT DTT DM6B9ZG MA Inhibitor DM6B9ZG RN Polyisoprenylated benzophenone, garcinol, a natural histone acetyltransferase inhibitor, represses chromatin transcription and alters global gene e... J Biol Chem. 2004 Aug 6;279(32):33716-26. DM6B9ZG RU https://pubmed.ncbi.nlm.nih.gov/15155757 DM6B9ZG DI DM6B9ZG DM6B9ZG DN garcinol DM6B9ZG MI TTH4VJL DM6B9ZG MN Histone acetyltransferase KAT6B (KAT6B) DM6B9ZG MT DTT DM6B9ZG MA Inhibitor DM6B9ZG RN Polyisoprenylated benzophenone, garcinol, a natural histone acetyltransferase inhibitor, represses chromatin transcription and alters global gene e... J Biol Chem. 2004 Aug 6;279(32):33716-26. DM6B9ZG RU https://pubmed.ncbi.nlm.nih.gov/15155757 DMQDV3U DI DMQDV3U DMQDV3U DN GARCINONE D DMQDV3U MI TTSZLWK DMQDV3U MN Aromatase (CYP19A1) DMQDV3U MT DTT DMQDV3U MA Inhibitor DMQDV3U RN Xanthones from the botanical dietary supplement mangosteen (Garcinia mangostana) with aromatase inhibitory activity. J Nat Prod. 2008 Jul;71(7):1161-6. DMQDV3U RU https://pubmed.ncbi.nlm.nih.gov/18558747 DMQDV3U DI DMQDV3U DMQDV3U DN GARCINONE D DMQDV3U MI TT50QJ3 DMQDV3U MN Influenza Neuraminidase (Influ NA) DMQDV3U MT DTT DMQDV3U MA Inhibitor DMQDV3U RN Xanthones with neuraminidase inhibitory activity from the seedcases of Garcinia mangostana. Bioorg Med Chem. 2010 Sep 1;18(17):6258-64. DMQDV3U RU https://pubmed.ncbi.nlm.nih.gov/20696581 DMZ5AD8 DI DMZ5AD8 DMZ5AD8 DN GARTANIN DMZ5AD8 MI TT50QJ3 DMZ5AD8 MN Influenza Neuraminidase (Influ NA) DMZ5AD8 MT DTT DMZ5AD8 MA Inhibitor DMZ5AD8 RN Xanthones with neuraminidase inhibitory activity from the seedcases of Garcinia mangostana. Bioorg Med Chem. 2010 Sep 1;18(17):6258-64. DMZ5AD8 RU https://pubmed.ncbi.nlm.nih.gov/20696581 DM7GX1S DI DM7GX1S DM7GX1S DN GARVEATIN A DM7GX1S MI TTZJYKH DM7GX1S MN Indoleamine 2,3-dioxygenase 1 (IDO1) DM7GX1S MT DTT DM7GX1S MA Inhibitor DM7GX1S RN Indoleamine 2,3-dioxygenase inhibitors from the Northeastern Pacific Marine Hydroid Garveia annulata. J Nat Prod. 2006 Oct;69(10):1496-9. DM7GX1S RU https://pubmed.ncbi.nlm.nih.gov/17067170 DMXNQ15 DI DMXNQ15 DMXNQ15 DN Garveatin C DMXNQ15 MI TTZJYKH DMXNQ15 MN Indoleamine 2,3-dioxygenase 1 (IDO1) DMXNQ15 MT DTT DMXNQ15 MA Inhibitor DMXNQ15 RN Indoleamine 2,3-dioxygenase inhibitors from the Northeastern Pacific Marine Hydroid Garveia annulata. J Nat Prod. 2006 Oct;69(10):1496-9. DMXNQ15 RU https://pubmed.ncbi.nlm.nih.gov/17067170 DMUFZ18 DI DMUFZ18 DMUFZ18 DN Garveatin E DMUFZ18 MI TTZJYKH DMUFZ18 MN Indoleamine 2,3-dioxygenase 1 (IDO1) DMUFZ18 MT DTT DMUFZ18 MA Inhibitor DMUFZ18 RN Indoleamine 2,3-dioxygenase inhibitors from the Northeastern Pacific Marine Hydroid Garveia annulata. J Nat Prod. 2006 Oct;69(10):1496-9. DMUFZ18 RU https://pubmed.ncbi.nlm.nih.gov/17067170 DMWFYJ4 DI DMWFYJ4 DMWFYJ4 DN GB110 DMWFYJ4 MI TTQR74A DMWFYJ4 MN Proteinase activated receptor 2 (PAR2) DMWFYJ4 MT DTT DMWFYJ4 MA Agonist DMWFYJ4 RN Novel agonists and antagonists for human protease activated receptor 2. J Med Chem. 2010 Oct 28;53(20):7428-40. DMWFYJ4 RU https://pubmed.ncbi.nlm.nih.gov/20873792 DM7B5HA DI DM7B5HA DM7B5HA DN GB-12819 DM7B5HA MI TTVG215 DM7B5HA MN Debrisoquine 4-hydroxylase (CYP2D6) DM7B5HA MT DTT DM7B5HA MA Inhibitor DM7B5HA RN Catalytic site prediction and virtual screening of cytochrome P450 2D6 substrates by consideration of water and rescoring in automated docking. J Med Chem. 2006 Apr 20;49(8):2417-30. DM7B5HA RU https://pubmed.ncbi.nlm.nih.gov/16610785 DM7B5HA DI DM7B5HA DM7B5HA DN GB-12819 DM7B5HA MI TTVBI8W DM7B5HA MN Dopamine transporter (DAT) DM7B5HA MT DTT DM7B5HA MA Inhibitor DM7B5HA RN Synthesis and dopamine transporter binding affinities of 3alpha-benzyl-8-(diarylmethoxyethyl)-8-azabicyclo[3.2.1]octanes. Bioorg Med Chem Lett. 2002 Sep 2;12(17):2387-90. DM7B5HA RU https://pubmed.ncbi.nlm.nih.gov/12161139 DMLDVFM DI DMLDVFM DMLDVFM DN GB88 DMLDVFM MI TTQR74A DMLDVFM MN Proteinase activated receptor 2 (PAR2) DMLDVFM MT DTT DMLDVFM MA Antagonist DMLDVFM RN Modulating human proteinase activated receptor 2 with a novel antagonist (GB88) and agonist (GB110). Br J Pharmacol. 2012 Mar;165(5):1413-23. DMLDVFM RU https://pubmed.ncbi.nlm.nih.gov/21806599 DMPOML4 DI DMPOML4 DMPOML4 DN GBR 12530 DMPOML4 MI TTVG215 DMPOML4 MN Debrisoquine 4-hydroxylase (CYP2D6) DMPOML4 MT DTT DMPOML4 MA Inhibitor DMPOML4 RN Catalytic site prediction and virtual screening of cytochrome P450 2D6 substrates by consideration of water and rescoring in automated docking. J Med Chem. 2006 Apr 20;49(8):2417-30. DMPOML4 RU https://pubmed.ncbi.nlm.nih.gov/16610785 DM2CUNP DI DM2CUNP DM2CUNP DN GBR-12289 DM2CUNP MI TTVG215 DM2CUNP MN Debrisoquine 4-hydroxylase (CYP2D6) DM2CUNP MT DTT DM2CUNP MA Inhibitor DM2CUNP RN Catalytic site prediction and virtual screening of cytochrome P450 2D6 substrates by consideration of water and rescoring in automated docking. J Med Chem. 2006 Apr 20;49(8):2417-30. DM2CUNP RU https://pubmed.ncbi.nlm.nih.gov/16610785 DMYMGBA DI DMYMGBA DMYMGBA DN GC-14 DMYMGBA MI TTQWUPT DMYMGBA MN Thyroid hormone receptor (THR) DMYMGBA MT DTT DMYMGBA MA Antagonist DMYMGBA RN Design of thyroid hormone receptor antagonists from first principles. J Steroid Biochem Mol Biol. 2002 Dec;83(1-5):59-73. DMYMGBA RU https://pubmed.ncbi.nlm.nih.gov/12650702 DM46HAS DI DM46HAS DM46HAS DN GC-2107 DM46HAS MI TTCIHJA DM46HAS MN Coagulation factor Xa (F10) DM46HAS MT DTT DM46HAS MA Inhibitor DM46HAS RN Semuloparin for the prevention of venous thromboembolic events in cancer patients. Drugs Today (Barc). 2012 Jul;48(7):451-7. DM46HAS RU https://pubmed.ncbi.nlm.nih.gov/22844656 DMSF8B9 DI DMSF8B9 DMSF8B9 DN GC-24 DMSF8B9 MI TTGER3L DMSF8B9 MN Thyroid hormone receptor beta (THRB) DMSF8B9 MT DTT DMSF8B9 MA Inhibitor DMSF8B9 RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMSF8B9 RU https://pubmed.ncbi.nlm.nih.gov/17139284 DM4BZEC DI DM4BZEC DM4BZEC DN GCCSHPACAGNNQHIC* DM4BZEC MI TTLA931 DM4BZEC MN Neuronal acetylcholine receptor alpha-7 (CHRNA7) DM4BZEC MT DTT DM4BZEC MA Inhibitor DM4BZEC RN Neuronal nicotinic acetylcholine receptors: structural revelations, target identifications, and therapeutic inspirations. J Med Chem. 2005 Jul 28;48(15):4705-45. DM4BZEC RU https://pubmed.ncbi.nlm.nih.gov/16033252 DM4BZEC DI DM4BZEC DM4BZEC DN GCCSHPACAGNNQHIC* DM4BZEC MI TT5KPZR DM4BZEC MN Neuronal acetylcholine receptor beta-2 (CHRNB2) DM4BZEC MT DTT DM4BZEC MA Inhibitor DM4BZEC RN Neuronal nicotinic acetylcholine receptors: structural revelations, target identifications, and therapeutic inspirations. J Med Chem. 2005 Jul 28;48(15):4705-45. DM4BZEC RU https://pubmed.ncbi.nlm.nih.gov/16033252 DMJ0ICN DI DMJ0ICN DMJ0ICN DN GCCSNPVCHLEHSNLC* DMJ0ICN MI TTLA931 DMJ0ICN MN Neuronal acetylcholine receptor alpha-7 (CHRNA7) DMJ0ICN MT DTT DMJ0ICN MA Inhibitor DMJ0ICN RN Neuronal nicotinic acetylcholine receptors: structural revelations, target identifications, and therapeutic inspirations. J Med Chem. 2005 Jul 28;48(15):4705-45. DMJ0ICN RU https://pubmed.ncbi.nlm.nih.gov/16033252 DMJ0ICN DI DMJ0ICN DMJ0ICN DN GCCSNPVCHLEHSNLC* DMJ0ICN MI TT5KPZR DMJ0ICN MN Neuronal acetylcholine receptor beta-2 (CHRNB2) DMJ0ICN MT DTT DMJ0ICN MA Inhibitor DMJ0ICN RN Neuronal nicotinic acetylcholine receptors: structural revelations, target identifications, and therapeutic inspirations. J Med Chem. 2005 Jul 28;48(15):4705-45. DMJ0ICN RU https://pubmed.ncbi.nlm.nih.gov/16033252 DMJ0ICN DI DMJ0ICN DMJ0ICN DN GCCSNPVCHLEHSNLC* DMJ0ICN MI TTTVAFQ DMJ0ICN MN Neuronal acetylcholine receptor beta-4 (CHRNB4) DMJ0ICN MT DTT DMJ0ICN MA Inhibitor DMJ0ICN RN Neuronal nicotinic acetylcholine receptors: structural revelations, target identifications, and therapeutic inspirations. J Med Chem. 2005 Jul 28;48(15):4705-45. DMJ0ICN RU https://pubmed.ncbi.nlm.nih.gov/16033252 DMVFDYU DI DMVFDYU DMVFDYU DN G-CSF DMVFDYU MI TTC70AJ DMVFDYU MN Granulocyte colony-stimulating factor receptor (G-CSF-R) DMVFDYU MT DTT DMVFDYU MA Stimulator DMVFDYU RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1719). DMVFDYU RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1719 DMF6MUB DI DMF6MUB DMF6MUB DN GDP-alpha-D-glucose DMF6MUB MI DE9P5K7 DMF6MUB MN GDP-D-glucose phosphorylase 1 (GDPGP1) DMF6MUB MT DME DMF6MUB MA Metabolism DMF6MUB RN A novel GDP-D-glucose phosphorylase involved in quality control of the nucleoside diphosphate sugar pool in Caenorhabditis elegans and mammals. J Biol Chem. 2011 Jun 17;286(24):21511-23. DMF6MUB RU https://www.ncbi.nlm.nih.gov/pubmed/?term=21507950 DMZMULS DI DMZMULS DMZMULS DN Gdp-Fucose DMZMULS MI DT3LZWR DMZMULS MN GDP-fucose transporter 1 (SLC35C1) DMZMULS MT DTP DMZMULS MA Substrate DMZMULS RN Golgi GDP-fucose transporter-deficient mice mimic congenital disorder of glycosylation IIc/leukocyte adhesion deficiency II. J Biol Chem. 2007 Apr 6;282(14):10762-72. DMZMULS RU http://www.ncbi.nlm.nih.gov/pubmed/17276979 DM9ARQ1 DI DM9ARQ1 DM9ARQ1 DN GDP-l-fucose DM9ARQ1 MI DEP8X02 DM9ARQ1 MN Fucosyltransferase X (FUT10) DM9ARQ1 MT DME DM9ARQ1 MA Metabolism DM9ARQ1 RN Activity, splice variants, conserved peptide motifs, and phylogeny of two new alpha1,3-fucosyltransferase families (FUT10 and FUT11). J Biol Chem. 2009 Feb 13;284(7):4723-38. DM9ARQ1 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=19088067 DM9ARQ1 DI DM9ARQ1 DM9ARQ1 DN GDP-l-fucose DM9ARQ1 MI DERG61P DM9ARQ1 MN Fucosyltransferase XI (FUT11) DM9ARQ1 MT DME DM9ARQ1 MA Metabolism DM9ARQ1 RN Activity, splice variants, conserved peptide motifs, and phylogeny of two new alpha1,3-fucosyltransferase families (FUT10 and FUT11). J Biol Chem. 2009 Feb 13;284(7):4723-38. DM9ARQ1 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=19088067 DMOC25M DI DMOC25M DMOC25M DN GDP-mannose DMOC25M MI DE8K7F3 DMOC25M MN GDP-mannose 4,6-dehydratase (GMDS) DMOC25M MT DME DMOC25M MA Metabolism DMOC25M RN Structural and enzymatic characterization of human recombinant GDP-D-mannose-4,6-dehydratase. FEBS Lett. 1999 Aug 13;456(3):370-4. DMOC25M RU https://www.ncbi.nlm.nih.gov/pubmed/?term=10462046 DMB813H DI DMB813H DMB813H DN GE-137 DMB813H MI TTNDSF4 DMB813H MN Proto-oncogene c-Met (MET) DMB813H MT DTT DMB813H MA Modulator DMB813H RN Detection of colorectal polyps in humans using an intravenously administered fluorescent peptide targeted against c-Met. Nat Med. 2015 Aug;21(8):955-61. DMB813H RU https://pubmed.ncbi.nlm.nih.gov/26168295 DMBGWEK DI DMBGWEK DMBGWEK DN GEA 3162 DMBGWEK MI TTEBMN7 DMBGWEK MN Long transient receptor potential channel 2 (TRPM2) DMBGWEK MT DTT DMBGWEK MA Activator DMBGWEK RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 494). DMBGWEK RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=494 DMUSJ96 DI DMUSJ96 DMUSJ96 DN Geldanamycin-estradiol hybrid DMUSJ96 MI TTR5TV4 DMUSJ96 MN ERBB2 messenger RNA (HER2 mRNA) DMUSJ96 MT DTT DMUSJ96 MA Inhibitor DMUSJ96 RN Synthesis and evaluation of geldanamycin-estradiol hybrids. Bioorg Med Chem Lett. 1999 May 3;9(9):1233-8. DMUSJ96 RU https://pubmed.ncbi.nlm.nih.gov/10340605 DMUSJ96 DI DMUSJ96 DMUSJ96 DN Geldanamycin-estradiol hybrid DMUSJ96 MI TTZAYWL DMUSJ96 MN Estrogen receptor (ESR) DMUSJ96 MT DTT DMUSJ96 MA Inhibitor DMUSJ96 RN Synthesis and evaluation of geldanamycin-estradiol hybrids. Bioorg Med Chem Lett. 1999 May 3;9(9):1233-8. DMUSJ96 RU https://pubmed.ncbi.nlm.nih.gov/10340605 DMUSJ96 DI DMUSJ96 DMUSJ96 DN Geldanamycin-estradiol hybrid DMUSJ96 MI TTOM3J0 DMUSJ96 MN Estrogen receptor beta (ESR2) DMUSJ96 MT DTT DMUSJ96 MA Inhibitor DMUSJ96 RN Synthesis and evaluation of geldanamycin-estradiol hybrids. Bioorg Med Chem Lett. 1999 May 3;9(9):1233-8. DMUSJ96 RU https://pubmed.ncbi.nlm.nih.gov/10340605 DMUSJ96 DI DMUSJ96 DMUSJ96 DN Geldanamycin-estradiol hybrid DMUSJ96 MI TT78R5H DMUSJ96 MN Heat shock protein 90 alpha (HSP90A) DMUSJ96 MT DTT DMUSJ96 MA Inhibitor DMUSJ96 RN Synthesis and evaluation of geldanamycin-estradiol hybrids. Bioorg Med Chem Lett. 1999 May 3;9(9):1233-8. DMUSJ96 RU https://pubmed.ncbi.nlm.nih.gov/10340605 DML0OUY DI DML0OUY DML0OUY DN Gelsolin DML0OUY MI TTE4KHA DML0OUY MN Amyloid beta A4 protein (APP) DML0OUY MT DTT DML0OUY RN Novel therapeutic approach for the treatment of Alzheimer's disease by peripheral administration of agents with an affinity to beta-amyloid. J Neurosci. 2003 Jan 1;23(1):29-33. DML0OUY RU https://pubmed.ncbi.nlm.nih.gov/12514198 DMETRIS DI DMETRIS DMETRIS DN gemini DMETRIS MI TTK59TV DMETRIS MN Vitamin D3 receptor (VDR) DMETRIS MT DTT DMETRIS MA Agonist DMETRIS RN Novel Gemini analogs of 1alpha,25-dihydroxyvitamin D(3) with enhanced transcriptional activity. Biochem Pharmacol. 2004 Apr 1;67(7):1327-36. DMETRIS RU https://pubmed.ncbi.nlm.nih.gov/15013848 DMAUFLQ DI DMAUFLQ DMAUFLQ DN GENESERINE DMAUFLQ MI TT1RS9F DMAUFLQ MN Acetylcholinesterase (AChE) DMAUFLQ MT DTT DMAUFLQ MA Inhibitor DMAUFLQ RN Structural determinants of Torpedo californica acetylcholinesterase inhibition by the novel and orally active carbamate based anti-alzheimer drug g... J Med Chem. 2006 Aug 24;49(17):5051-8. DMAUFLQ RU https://pubmed.ncbi.nlm.nih.gov/16913695 DMMLNTW DI DMMLNTW DMMLNTW DN Genistein-7-glucoside DMMLNTW MI DTFI42L DMMLNTW MN Multidrug resistance-associated protein 2 (ABCC2) DMMLNTW MT DTP DMMLNTW MA Substrate DMMLNTW RN Mammalian drug efflux transporters of the ATP binding cassette (ABC) family in multidrug resistance: A review of the past decade. Cancer Lett. 2016 Jan 1;370(1):153-64. DMMLNTW RU http://www.ncbi.nlm.nih.gov/pubmed/26499806 DMB70WC DI DMB70WC DMB70WC DN Genz-10850 DMB70WC MI TTVTX4N DMB70WC MN Bacterial Fatty acid synthetase I (Bact inhA) DMB70WC MT DTT DMB70WC MA Inhibitor DMB70WC RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMB70WC RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMB5I03 DI DMB5I03 DMB5I03 DN GERANIIN DMB5I03 MI TTE14XG DMB5I03 MN Squalene monooxygenase (SQLE) DMB5I03 MT DTT DMB5I03 MA Inhibitor DMB5I03 RN Ellagitannins and hexahydroxydiphenoyl esters as inhibitors of vertebrate squalene epoxidase. J Nat Prod. 2001 Aug;64(8):1010-4. DMB5I03 RU https://pubmed.ncbi.nlm.nih.gov/11520216 DMS3CBD DI DMS3CBD DMS3CBD DN geraniol DMS3CBD MI TTXDKTO DMS3CBD MN Long transient receptor potential channel 8 (TRPM8) DMS3CBD MT DTT DMS3CBD MA Activator DMS3CBD RN Characterization of the mouse cold-menthol receptor TRPM8 and vanilloid receptor type-1 VR1 using a fluorometric imaging plate reader (FLIPR) assay. Br J Pharmacol. 2004 Feb;141(4):737-45. DMS3CBD RU https://pubmed.ncbi.nlm.nih.gov/14757700 DMB9LE1 DI DMB9LE1 DMB9LE1 DN Geranyl Diphosphate DMB9LE1 MI TTIKWV4 DMB9LE1 MN Geranyltranstransferase (FDPS) DMB9LE1 MT DTT DMB9LE1 MA Inhibitor DMB9LE1 RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMB9LE1 RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMRPWGL DI DMRPWGL DMRPWGL DN Geranylcoumarin DMRPWGL MI TTXV4FI DMRPWGL MN Albendazole monooxygenase (CYP3A4) DMRPWGL MT DTT DMRPWGL MA Inhibitor DMRPWGL RN Radical scavenging and cytochrome P450 3A4 inhibitory activity of bergaptol and geranylcoumarin from grapefruit. Bioorg Med Chem. 2007 Jun 1;15(11):3684-91. DMRPWGL RU https://pubmed.ncbi.nlm.nih.gov/17400460 DMJZ0AM DI DMJZ0AM DMJZ0AM DN GERANYLGERANYL DIPHOSPHATE DMJZ0AM MI TT7WZIJ DMJZ0AM MN CAAX farnesyltransferase beta (FNTB) DMJZ0AM MT DTT DMJZ0AM MA Inhibitor DMJZ0AM RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DMJZ0AM RU https://pubmed.ncbi.nlm.nih.gov/10592235 DMJZ0AM DI DMJZ0AM DMJZ0AM DN GERANYLGERANYL DIPHOSPHATE DMJZ0AM MI TTXQKM3 DMJZ0AM MN Farnesyl protein transferase (Ftase) DMJZ0AM MT DTT DMJZ0AM MA Inhibitor DMJZ0AM RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DMJZ0AM RU https://pubmed.ncbi.nlm.nih.gov/10592235 DMJZ0AM DI DMJZ0AM DMJZ0AM DN GERANYLGERANYL DIPHOSPHATE DMJZ0AM MI TTIKWV4 DMJZ0AM MN Geranyltranstransferase (FDPS) DMJZ0AM MT DTT DMJZ0AM MA Inhibitor DMJZ0AM RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DMJZ0AM RU https://pubmed.ncbi.nlm.nih.gov/10592235 DMLM02I DI DMLM02I DMLM02I DN GFPDGG DMLM02I MI TTPADOQ DMLM02I MN HMG-CoA reductase (HMGCR) DMLM02I MT DTT DMLM02I MA Inhibitor DMLM02I RN Binding effect and design of a competitive inhibitory peptide for HMG-CoA reductase through modeling of an active peptide backbone. Bioorg Med Chem. 2008 Feb 1;16(3):1309-18. DMLM02I RU https://pubmed.ncbi.nlm.nih.gov/17977732 DMGZTQW DI DMGZTQW DMGZTQW DN GFPEGG DMGZTQW MI TTPADOQ DMGZTQW MN HMG-CoA reductase (HMGCR) DMGZTQW MT DTT DMGZTQW MA Inhibitor DMGZTQW RN Binding effect and design of a competitive inhibitory peptide for HMG-CoA reductase through modeling of an active peptide backbone. Bioorg Med Chem. 2008 Feb 1;16(3):1309-18. DMGZTQW RU https://pubmed.ncbi.nlm.nih.gov/17977732 DM9D8VH DI DM9D8VH DM9D8VH DN GFPTGG DM9D8VH MI TTPADOQ DM9D8VH MN HMG-CoA reductase (HMGCR) DM9D8VH MT DTT DM9D8VH MA Inhibitor DM9D8VH RN Binding effect and design of a competitive inhibitory peptide for HMG-CoA reductase through modeling of an active peptide backbone. Bioorg Med Chem. 2008 Feb 1;16(3):1309-18. DM9D8VH RU https://pubmed.ncbi.nlm.nih.gov/17977732 DMU82JV DI DMU82JV DMU82JV DN GG-818 DMU82JV MI TTNGILX DMU82JV MN Adrenergic receptor alpha-1A (ADRA1A) DMU82JV MT DTT DMU82JV MA Antagonist DMU82JV RN In situ salt screening--a useful technique for discovery support and preformulation studies. Pharm Dev Technol. 1998 May;3(2):215-23. DMU82JV RU https://pubmed.ncbi.nlm.nih.gov/9653759 DMU92RC DI DMU92RC DMU92RC DN GI-3000 DMU92RC MI TTGKNB4 DMU92RC MN Epidermal growth factor receptor (EGFR) DMU92RC MT DTT DMU92RC RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1797). DMU92RC RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1797 DMASR6T DI DMASR6T DMASR6T DN GIDAZEPAM DMASR6T MI TTEX6LM DMASR6T MN GABA(A) receptor gamma-3 (GABRG3) DMASR6T MT DTT DMASR6T MA Modulator DMASR6T RN Discriminative effects of phenazepam and gidazepam in rats: comparison with other GABA-related drugs. Pharmacol Biochem Behav. 1999 Oct;64(2):397-401. DMASR6T RU https://pubmed.ncbi.nlm.nih.gov/10515320 DMNXYSM DI DMNXYSM DMNXYSM DN gingerol DMNXYSM MI TTELV3W DMNXYSM MN Transformation-sensitive protein p120 (TRPA1) DMNXYSM MT DTT DMNXYSM MA Activator DMNXYSM RN Noxious cold ion channel TRPA1 is activated by pungent compounds and bradykinin. Neuron. 2004 Mar 25;41(6):849-57. DMNXYSM RU https://pubmed.ncbi.nlm.nih.gov/15046718 DMKZJ7T DI DMKZJ7T DMKZJ7T DN GINKGOLIDE A DMKZJ7T MI TTZ8EM9 DMKZJ7T MN Glycine receptor (GlyR) DMKZJ7T MT DTT DMKZJ7T MA Inhibitor DMKZJ7T RN Probing the pharmacophore of ginkgolides as glycine receptor antagonists. J Med Chem. 2007 Apr 5;50(7):1610-7. DMKZJ7T RU https://pubmed.ncbi.nlm.nih.gov/17352465 DMKZJ7T DI DMKZJ7T DMKZJ7T DN GINKGOLIDE A DMKZJ7T MI TTF45NW DMKZJ7T MN Strychnine-binding glycine receptor (GLRA1) DMKZJ7T MT DTT DMKZJ7T MA Inhibitor DMKZJ7T RN Probing the pharmacophore of ginkgolides as glycine receptor antagonists. J Med Chem. 2007 Apr 5;50(7):1610-7. DMKZJ7T RU https://pubmed.ncbi.nlm.nih.gov/17352465 DMVN374 DI DMVN374 DMVN374 DN Ginkgolide C DMVN374 MI TTZ8EM9 DMVN374 MN Glycine receptor (GlyR) DMVN374 MT DTT DMVN374 MA Inhibitor DMVN374 RN Probing the pharmacophore of ginkgolides as glycine receptor antagonists. J Med Chem. 2007 Apr 5;50(7):1610-7. DMVN374 RU https://pubmed.ncbi.nlm.nih.gov/17352465 DMVN374 DI DMVN374 DMVN374 DN Ginkgolide C DMVN374 MI TTF45NW DMVN374 MN Strychnine-binding glycine receptor (GLRA1) DMVN374 MT DTT DMVN374 MA Inhibitor DMVN374 RN Probing the pharmacophore of ginkgolides as glycine receptor antagonists. J Med Chem. 2007 Apr 5;50(7):1610-7. DMVN374 RU https://pubmed.ncbi.nlm.nih.gov/17352465 DMUOMP1 DI DMUOMP1 DMUOMP1 DN Ginkgolide J DMUOMP1 MI TTZ8EM9 DMUOMP1 MN Glycine receptor (GlyR) DMUOMP1 MT DTT DMUOMP1 MA Inhibitor DMUOMP1 RN Probing the pharmacophore of ginkgolides as glycine receptor antagonists. J Med Chem. 2007 Apr 5;50(7):1610-7. DMUOMP1 RU https://pubmed.ncbi.nlm.nih.gov/17352465 DMUOMP1 DI DMUOMP1 DMUOMP1 DN Ginkgolide J DMUOMP1 MI TTF45NW DMUOMP1 MN Strychnine-binding glycine receptor (GLRA1) DMUOMP1 MT DTT DMUOMP1 MA Inhibitor DMUOMP1 RN Probing the pharmacophore of ginkgolides as glycine receptor antagonists. J Med Chem. 2007 Apr 5;50(7):1610-7. DMUOMP1 RU https://pubmed.ncbi.nlm.nih.gov/17352465 DMHWIG6 DI DMHWIG6 DMHWIG6 DN Ginkgolide M DMHWIG6 MI TTZ8EM9 DMHWIG6 MN Glycine receptor (GlyR) DMHWIG6 MT DTT DMHWIG6 MA Inhibitor DMHWIG6 RN Probing the pharmacophore of ginkgolides as glycine receptor antagonists. J Med Chem. 2007 Apr 5;50(7):1610-7. DMHWIG6 RU https://pubmed.ncbi.nlm.nih.gov/17352465 DMHWIG6 DI DMHWIG6 DMHWIG6 DN Ginkgolide M DMHWIG6 MI TTF45NW DMHWIG6 MN Strychnine-binding glycine receptor (GLRA1) DMHWIG6 MT DTT DMHWIG6 MA Inhibitor DMHWIG6 RN Probing the pharmacophore of ginkgolides as glycine receptor antagonists. J Med Chem. 2007 Apr 5;50(7):1610-7. DMHWIG6 RU https://pubmed.ncbi.nlm.nih.gov/17352465 DMK543E DI DMK543E DMK543E DN ginkgolide X DMK543E MI TTZ8EM9 DMK543E MN Glycine receptor (GlyR) DMK543E MT DTT DMK543E MA Antagonist DMK543E RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 427). DMK543E RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=427 DMF70AB DI DMF70AB DMF70AB DN Ginsenoside Rb1 DMF70AB MI DEUO7V8 DMF70AB MN Beta-glucosidase (bglA) DMF70AB MT DME DMF70AB MA Metabolism DMF70AB RN Constitutive beta-glucosidases hydrolyzing ginsenoside Rb1 and Rb2 from human intestinal bacteria. Biol Pharm Bull. 2000 Dec;23(12):1481-5. DMF70AB RU https://pubmed.ncbi.nlm.nih.gov/11145182 DMF70AB DI DMF70AB DMF70AB DN Ginsenoside Rb1 DMF70AB MI DE4LKZ9 DMF70AB MN Beta-glucosidase (bglA) DMF70AB MT DME DMF70AB MA Metabolism DMF70AB RN Constitutive beta-glucosidases hydrolyzing ginsenoside Rb1 and Rb2 from human intestinal bacteria. Biol Pharm Bull. 2000 Dec;23(12):1481-5. DMF70AB RU https://pubmed.ncbi.nlm.nih.gov/11145182 DMF70AB DI DMF70AB DMF70AB DN Ginsenoside Rb1 DMF70AB MI DEM6GYO DMF70AB MN Beta-glucosidase (bglA) DMF70AB MT DME DMF70AB MA Metabolism DMF70AB RN nan DMF70AB RU nan DMF70AB DI DMF70AB DMF70AB DN Ginsenoside Rb1 DMF70AB MI DE9N4OU DMF70AB MN Beta-glucosidase (bglA) DMF70AB MT DME DMF70AB MA Metabolism DMF70AB RN Characterization of the ginsenoside-transforming recombinant beta-glucosidase from Actinosynnema mirum and bioconversion of major ginsenosides into minor ginsenosides. Appl Microbiol Biotechnol. 2013 Jan;97(2):649-59. DMF70AB RU https://pubmed.ncbi.nlm.nih.gov/22911093 DMF70AB DI DMF70AB DMF70AB DN Ginsenoside Rb1 DMF70AB MI DERPJZ6 DMF70AB MN Beta-glucosidase (bglA) DMF70AB MT DME DMF70AB MA Metabolism DMF70AB RN Fermentation of protopanaxadiol type ginsenosides (PD) with probiotic Bifidobacterium lactis and Lactobacillus rhamnosus. Appl Microbiol Biotechnol. 2017 Jul;101(13):5427-5437. DMF70AB RU https://pubmed.ncbi.nlm.nih.gov/28478490 DMF70AB DI DMF70AB DMF70AB DN Ginsenoside Rb1 DMF70AB MI DEVLXCG DMF70AB MN Beta-glucosidase (bglA) DMF70AB MT DME DMF70AB MA Metabolism DMF70AB RN Constitutive beta-glucosidases hydrolyzing ginsenoside Rb1 and Rb2 from human intestinal bacteria. Biol Pharm Bull. 2000 Dec;23(12):1481-5. DMF70AB RU https://pubmed.ncbi.nlm.nih.gov/11145182 DMF70AB DI DMF70AB DMF70AB DN Ginsenoside Rb1 DMF70AB MI DEUQTKA DMF70AB MN Beta-glucosidase (bglA) DMF70AB MT DME DMF70AB MA Metabolism DMF70AB RN Fermentation of protopanaxadiol type ginsenosides (PD) with probiotic Bifidobacterium lactis and Lactobacillus rhamnosus. Appl Microbiol Biotechnol. 2017 Jul;101(13):5427-5437. DMF70AB RU https://pubmed.ncbi.nlm.nih.gov/28478490 DMF70AB DI DMF70AB DMF70AB DN Ginsenoside Rb1 DMF70AB MI DEXRUS1 DMF70AB MN Beta-glucosidase (bglA) DMF70AB MT DME DMF70AB MA Metabolism DMF70AB RN Developing a metagenomic view of xenobiotic metabolism. Pharmacol Res. 2013 Mar;69(1):21-31. DMF70AB RU https://pubmed.ncbi.nlm.nih.gov/22902524 DMF70AB DI DMF70AB DMF70AB DN Ginsenoside Rb1 DMF70AB MI DERX7ML DMF70AB MN Beta-glucosidase (bglA) DMF70AB MT DME DMF70AB MA Metabolism DMF70AB RN Developing a metagenomic view of xenobiotic metabolism. Pharmacol Res. 2013 Mar;69(1):21-31. DMF70AB RU https://pubmed.ncbi.nlm.nih.gov/22902524 DMF70AB DI DMF70AB DMF70AB DN Ginsenoside Rb1 DMF70AB MI DEOHI3U DMF70AB MN Beta-glucosidase (bglA) DMF70AB MT DME DMF70AB MA Metabolism DMF70AB RN Developing a metagenomic view of xenobiotic metabolism. Pharmacol Res. 2013 Mar;69(1):21-31. DMF70AB RU https://pubmed.ncbi.nlm.nih.gov/22902524 DMF70AB DI DMF70AB DMF70AB DN Ginsenoside Rb1 DMF70AB MI DE46IH1 DMF70AB MN Beta-glucosidase (bglA) DMF70AB MT DME DMF70AB MA Metabolism DMF70AB RN Genus Enhydrobacter Staley et al. 1987 should be recognized as a member of the family Rhodospirillaceae within the class Alphaproteobacteria. Microbiol Immunol. 2012 Jan;56(1):21-6. DMF70AB RU https://pubmed.ncbi.nlm.nih.gov/22145860 DMF70AB DI DMF70AB DMF70AB DN Ginsenoside Rb1 DMF70AB MI DEE8WXK DMF70AB MN Beta-glucosidase (bglA) DMF70AB MT DME DMF70AB MA Metabolism DMF70AB RN Developing a metagenomic view of xenobiotic metabolism. Pharmacol Res. 2013 Mar;69(1):21-31. DMF70AB RU https://pubmed.ncbi.nlm.nih.gov/22902524 DMF70AB DI DMF70AB DMF70AB DN Ginsenoside Rb1 DMF70AB MI DECBSVP DMF70AB MN Beta-glucosidase (bglA) DMF70AB MT DME DMF70AB MA Metabolism DMF70AB RN Developing a metagenomic view of xenobiotic metabolism. Pharmacol Res. 2013 Mar;69(1):21-31. DMF70AB RU https://pubmed.ncbi.nlm.nih.gov/22902524 DMF70AB DI DMF70AB DMF70AB DN Ginsenoside Rb1 DMF70AB MI DEAVLU4 DMF70AB MN Beta-glucosidase (bglA) DMF70AB MT DME DMF70AB MA Metabolism DMF70AB RN Developing a metagenomic view of xenobiotic metabolism. Pharmacol Res. 2013 Mar;69(1):21-31. DMF70AB RU https://pubmed.ncbi.nlm.nih.gov/22902524 DMF70AB DI DMF70AB DMF70AB DN Ginsenoside Rb1 DMF70AB MI DEPBQES DMF70AB MN Beta-glucosidase (bglA) DMF70AB MT DME DMF70AB MA Metabolism DMF70AB RN Developing a metagenomic view of xenobiotic metabolism. Pharmacol Res. 2013 Mar;69(1):21-31. DMF70AB RU https://pubmed.ncbi.nlm.nih.gov/22902524 DMF70AB DI DMF70AB DMF70AB DN Ginsenoside Rb1 DMF70AB MI DEGVUWH DMF70AB MN Beta-glucosidase (bglA) DMF70AB MT DME DMF70AB MA Metabolism DMF70AB RN Developing a metagenomic view of xenobiotic metabolism. Pharmacol Res. 2013 Mar;69(1):21-31. DMF70AB RU https://pubmed.ncbi.nlm.nih.gov/22902524 DMF70AB DI DMF70AB DMF70AB DN Ginsenoside Rb1 DMF70AB MI DEE8RS0 DMF70AB MN Beta-glucosidase (bglA) DMF70AB MT DME DMF70AB MA Metabolism DMF70AB RN Developing a metagenomic view of xenobiotic metabolism. Pharmacol Res. 2013 Mar;69(1):21-31. DMF70AB RU https://pubmed.ncbi.nlm.nih.gov/22902524 DMF70AB DI DMF70AB DMF70AB DN Ginsenoside Rb1 DMF70AB MI DEC0M8H DMF70AB MN Beta-glucosidase (bglA) DMF70AB MT DME DMF70AB MA Metabolism DMF70AB RN Developing a metagenomic view of xenobiotic metabolism. Pharmacol Res. 2013 Mar;69(1):21-31. DMF70AB RU https://pubmed.ncbi.nlm.nih.gov/22902524 DMF70AB DI DMF70AB DMF70AB DN Ginsenoside Rb1 DMF70AB MI DE2OMS0 DMF70AB MN Beta-glucosidase (bglA) DMF70AB MT DME DMF70AB MA Metabolism DMF70AB RN Developing a metagenomic view of xenobiotic metabolism. Pharmacol Res. 2013 Mar;69(1):21-31. DMF70AB RU https://pubmed.ncbi.nlm.nih.gov/22902524 DMF70AB DI DMF70AB DMF70AB DN Ginsenoside Rb1 DMF70AB MI DEPUNVR DMF70AB MN Beta-glucosidase (bglA) DMF70AB MT DME DMF70AB MA Metabolism DMF70AB RN Developing a metagenomic view of xenobiotic metabolism. Pharmacol Res. 2013 Mar;69(1):21-31. DMF70AB RU https://pubmed.ncbi.nlm.nih.gov/22902524 DMF70AB DI DMF70AB DMF70AB DN Ginsenoside Rb1 DMF70AB MI DEX7SAW DMF70AB MN Beta-glucosidase (bglA) DMF70AB MT DME DMF70AB MA Metabolism DMF70AB RN Developing a metagenomic view of xenobiotic metabolism. Pharmacol Res. 2013 Mar;69(1):21-31. DMF70AB RU https://pubmed.ncbi.nlm.nih.gov/22902524 DMF70AB DI DMF70AB DMF70AB DN Ginsenoside Rb1 DMF70AB MI DEE3I1P DMF70AB MN Beta-glucosidase (bglA) DMF70AB MT DME DMF70AB MA Metabolism DMF70AB RN Developing a metagenomic view of xenobiotic metabolism. Pharmacol Res. 2013 Mar;69(1):21-31. DMF70AB RU https://pubmed.ncbi.nlm.nih.gov/22902524 DMF70AB DI DMF70AB DMF70AB DN Ginsenoside Rb1 DMF70AB MI DEASJG5 DMF70AB MN Beta-glucosidase (bglA) DMF70AB MT DME DMF70AB MA Metabolism DMF70AB RN Developing a metagenomic view of xenobiotic metabolism. Pharmacol Res. 2013 Mar;69(1):21-31. DMF70AB RU https://pubmed.ncbi.nlm.nih.gov/22902524 DMES9Q2 DI DMES9Q2 DMES9Q2 DN Ginsenoside Rc DMES9Q2 MI DERPJZ6 DMES9Q2 MN Beta-glucosidase (bglA) DMES9Q2 MT DME DMES9Q2 MA Metabolism DMES9Q2 RN Fermentation of protopanaxadiol type ginsenosides (PD) with probiotic Bifidobacterium lactis and Lactobacillus rhamnosus. Appl Microbiol Biotechnol. 2017 Jul;101(13):5427-5437. DMES9Q2 RU https://pubmed.ncbi.nlm.nih.gov/28478490 DMES9Q2 DI DMES9Q2 DMES9Q2 DN Ginsenoside Rc DMES9Q2 MI DEUQTKA DMES9Q2 MN Beta-glucosidase (bglA) DMES9Q2 MT DME DMES9Q2 MA Metabolism DMES9Q2 RN Fermentation of protopanaxadiol type ginsenosides (PD) with probiotic Bifidobacterium lactis and Lactobacillus rhamnosus. Appl Microbiol Biotechnol. 2017 Jul;101(13):5427-5437. DMES9Q2 RU https://pubmed.ncbi.nlm.nih.gov/28478490 DM46FVD DI DM46FVD DM46FVD DN Ginsenoside Re DM46FVD MI DEBI82Z DM46FVD MN Alpha-L-rhamnosidase (lrA) DM46FVD MT DME DM46FVD MA Metabolism DM46FVD RN Metabolism of rutin and poncirin by human intestinal microbiota and cloning of their metabolizing alpha-L-rhamnosidase from Bifidobacterium dentium. J Microbiol Biotechnol. 2015 Jan;25(1):18-25. DM46FVD RU https://pubmed.ncbi.nlm.nih.gov/25179902 DM46FVD DI DM46FVD DM46FVD DN Ginsenoside Re DM46FVD MI DE9N4OU DM46FVD MN Beta-glucosidase (bglA) DM46FVD MT DME DM46FVD MA Metabolism DM46FVD RN Characterization of the ginsenoside-transforming recombinant beta-glucosidase from Actinosynnema mirum and bioconversion of major ginsenosides into minor ginsenosides. Appl Microbiol Biotechnol. 2013 Jan;97(2):649-59. DM46FVD RU https://pubmed.ncbi.nlm.nih.gov/22911093 DMYE2SR DI DMYE2SR DMYE2SR DN Ginsenoside Rg1 DMYE2SR MI DE9N4OU DMYE2SR MN Beta-glucosidase (bglA) DMYE2SR MT DME DMYE2SR MA Metabolism DMYE2SR RN Characterization of the ginsenoside-transforming recombinant beta-glucosidase from Actinosynnema mirum and bioconversion of major ginsenosides into minor ginsenosides. Appl Microbiol Biotechnol. 2013 Jan;97(2):649-59. DMYE2SR RU https://pubmed.ncbi.nlm.nih.gov/22911093 DMFN58T DI DMFN58T DMFN58T DN Ginsenoside RG3 DMFN58T MI TTQ6VDM DMFN58T MN Voltage-gated potassium channel Kv11.1 (KCNH2) DMFN58T MT DTT DMFN58T MA Activator DMFN58T RN Ginsenoside Rg(3) decelerates hERG K(+) channel deactivation through Ser631 residue interaction. Eur J Pharmacol. 2011 Aug 1;663(1-3):59-67. DMFN58T RU https://pubmed.ncbi.nlm.nih.gov/21586280 DM9P62Y DI DM9P62Y DM9P62Y DN GKA1 DM9P62Y MI TTDLNGZ DM9P62Y MN Glucokinase (GCK) DM9P62Y MT DTT DM9P62Y MA Activator DM9P62Y RN Stimulation of hepatocyte glucose metabolism by novel small molecule glucokinase activators. Diabetes. 2004 Mar;53(3):535-41. DM9P62Y RU https://pubmed.ncbi.nlm.nih.gov/14988235 DMIENSW DI DMIENSW DMIENSW DN GKA-23 DMIENSW MI TTDLNGZ DMIENSW MN Glucokinase (GCK) DMIENSW MT DTT DMIENSW MA Activator DMIENSW RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2798). DMIENSW RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2798 DMSP7V8 DI DMSP7V8 DMSP7V8 DN GLAUCINE DMSP7V8 MI TTZFYLI DMSP7V8 MN Dopamine D1 receptor (D1R) DMSP7V8 MT DTT DMSP7V8 MA Inhibitor DMSP7V8 RN Advances in development of dopaminergic aporphinoids. J Med Chem. 2007 Jan 25;50(2):171-81. DMSP7V8 RU https://pubmed.ncbi.nlm.nih.gov/17228858 DMSP7V8 DI DMSP7V8 DMSP7V8 DN GLAUCINE DMSP7V8 MI TTEX248 DMSP7V8 MN Dopamine D2 receptor (D2R) DMSP7V8 MT DTT DMSP7V8 MA Inhibitor DMSP7V8 RN Advances in development of dopaminergic aporphinoids. J Med Chem. 2007 Jan 25;50(2):171-81. DMSP7V8 RU https://pubmed.ncbi.nlm.nih.gov/17228858 DM4QJPU DI DM4QJPU DM4QJPU DN Glaxo-11p DM4QJPU MI TTCG0AL DM4QJPU MN Cholecystokinin receptor type A (CCKAR) DM4QJPU MT DTT DM4QJPU MA Agonist DM4QJPU RN Discovery of 1,5-benzodiazepines with peripheral cholecystokinin (CCK-A) receptor agonist activity. 1. Optimization of the agonist "trigger". J Med Chem. 1996 Jan 19;39(2):562-9. DM4QJPU RU https://pubmed.ncbi.nlm.nih.gov/8558528 DMNEML0 DI DMNEML0 DMNEML0 DN GlaxoSmithKline compound 5h DMNEML0 MI TTA93TL DMNEML0 MN P2Y purinoceptor 1 (P2RY1) DMNEML0 MT DTT DMNEML0 MA Antagonist DMNEML0 RN Benzofuran-substituted urea derivatives as novel P2Y(1) receptor antagonists. Bioorg Med Chem Lett. 2010 Jul 15;20(14):4104-7. DMNEML0 RU https://pubmed.ncbi.nlm.nih.gov/20542694 DM1UAWP DI DM1UAWP DM1UAWP DN GlaxoSmithKline compound 6i DM1UAWP MI TTA93TL DM1UAWP MN P2Y purinoceptor 1 (P2RY1) DM1UAWP MT DTT DM1UAWP MA Antagonist DM1UAWP RN Tetrahydro-4-quinolinamines identified as novel P2Y(1) receptor antagonists. Bioorg Med Chem Lett. 2008 Dec 1;18(23):6222-6. DM1UAWP RU https://pubmed.ncbi.nlm.nih.gov/18926700 DM98CSW DI DM98CSW DM98CSW DN Glionitrin A DM98CSW MI TTPF2QI DM98CSW MN Caspase-3 (CASP3) DM98CSW MT DTT DM98CSW MA Modulator DM98CSW RN Glionitrin A, a new diketopiperazine disulfide, activates ATM-ATR-Chk1/2 via 53BP1 phosphorylation in DU145 cells and shows antitumor effect in xenograft model. Biol Pharm Bull. 2014;37(3):378-86. DM98CSW RU https://pubmed.ncbi.nlm.nih.gov/24583858 DM98CSW DI DM98CSW DM98CSW DN Glionitrin A DM98CSW MI TTEVCT0 DM98CSW MN Caspase-8 (CASP8) DM98CSW MT DTT DM98CSW MA Modulator DM98CSW RN Glionitrin A, a new diketopiperazine disulfide, activates ATM-ATR-Chk1/2 via 53BP1 phosphorylation in DU145 cells and shows antitumor effect in xenograft model. Biol Pharm Bull. 2014;37(3):378-86. DM98CSW RU https://pubmed.ncbi.nlm.nih.gov/24583858 DM98CSW DI DM98CSW DM98CSW DN Glionitrin A DM98CSW MI TTB6T7O DM98CSW MN Caspase-9 (CASP9) DM98CSW MT DTT DM98CSW MA Modulator DM98CSW RN Glionitrin A, a new diketopiperazine disulfide, activates ATM-ATR-Chk1/2 via 53BP1 phosphorylation in DU145 cells and shows antitumor effect in xenograft model. Biol Pharm Bull. 2014;37(3):378-86. DM98CSW RU https://pubmed.ncbi.nlm.nih.gov/24583858 DMBH18C DI DMBH18C DMBH18C DN GLP-17-(7-36) derivative DMBH18C MI TTVIMDE DMBH18C MN Glucagon-like peptide 1 receptor (GLP1R) DMBH18C MT DTT DMBH18C MA Inhibitor DMBH18C RN Identification of CJC-1131-albumin bioconjugate as a stable and bioactive GLP-1(7-36) analog. Bioorg Med Chem Lett. 2004 Sep 6;14(17):4395-8. DMBH18C RU https://pubmed.ncbi.nlm.nih.gov/15357960 DMGTPDA DI DMGTPDA DMGTPDA DN GLPDGG peptide DMGTPDA MI TTPADOQ DMGTPDA MN HMG-CoA reductase (HMGCR) DMGTPDA MT DTT DMGTPDA MA Inhibitor DMGTPDA RN Peptide fragmentation as an approach in modeling of an active peptide and designing a competitive inhibitory peptide for HMG-CoA reductase. Bioorg Med Chem. 2010 Jun 15;18(12):4300-9. DMGTPDA RU https://pubmed.ncbi.nlm.nih.gov/20494585 DME2YL6 DI DME2YL6 DME2YL6 DN GLPTGG DME2YL6 MI TTPADOQ DME2YL6 MN HMG-CoA reductase (HMGCR) DME2YL6 MT DTT DME2YL6 MA Inhibitor DME2YL6 RN Binding effect and design of a competitive inhibitory peptide for HMG-CoA reductase through modeling of an active peptide backbone. Bioorg Med Chem. 2008 Feb 1;16(3):1309-18. DME2YL6 RU https://pubmed.ncbi.nlm.nih.gov/17977732 DM0HWB1 DI DM0HWB1 DM0HWB1 DN Glu20-Lys24][Gly8][GLP-1(7-37)-NH2 DM0HWB1 MI TTVIMDE DM0HWB1 MN Glucagon-like peptide 1 receptor (GLP1R) DM0HWB1 MT DTT DM0HWB1 MA Inhibitor DM0HWB1 RN Design and synthesis of conformationally constrained glucagon-like peptide-1 derivatives with increased plasma stability and prolonged in vivo acti... J Med Chem. 2008 May 8;51(9):2758-65. DM0HWB1 RU https://pubmed.ncbi.nlm.nih.gov/18412318 DMVWDHM DI DMVWDHM DMVWDHM DN glucagon-(1-6) DMVWDHM MI TT9O6WS DMVWDHM MN Glucagon receptor (GCGR) DMVWDHM MT DTT DMVWDHM MA Agonist DMVWDHM RN Glucagon1-6 binds to the glucagon receptor and activates hepatic adenylate cyclase. J Biol Chem. 1979 Jan 25;254(2):268-9. DMVWDHM RU https://pubmed.ncbi.nlm.nih.gov/216670 DMZLRY2 DI DMZLRY2 DMZLRY2 DN Glucagon-like peptide-1 analog DMZLRY2 MI TTVIMDE DMZLRY2 MN Glucagon-like peptide 1 receptor (GLP1R) DMZLRY2 MT DTT DMZLRY2 MA Modulator DMZLRY2 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 249). DMZLRY2 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=249 DMO071E DI DMO071E DMO071E DN Gluconolactone DMO071E MI TTA0OSE DMO071E MN Lactase-phlorizin hydrolase (LCT) DMO071E MT DTT DMO071E MA Inhibitor DMO071E RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DMO071E RU https://pubmed.ncbi.nlm.nih.gov/10592235 DMRHYU8 DI DMRHYU8 DMRHYU8 DN Glucopyranosyl oleanolate DMRHYU8 MI DEVLXCG DMRHYU8 MN Beta-glucosidase (bglA) DMRHYU8 MT DME DMRHYU8 MA Metabolism DMRHYU8 RN Constitutive beta-glucosidases hydrolyzing ginsenoside Rb1 and Rb2 from human intestinal bacteria. Biol Pharm Bull. 2000 Dec;23(12):1481-5. DMRHYU8 RU https://pubmed.ncbi.nlm.nih.gov/11145182 DMY590Q DI DMY590Q DMY590Q DN Glucosamine 6-Phosphate DMY590Q MI TTC67I0 DMY590Q MN Bacterial Glucosamine-6-phosphate synthase (Bact glmS) DMY590Q MT DTT DMY590Q MA Inhibitor DMY590Q RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMY590Q RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMLISP2 DI DMLISP2 DMLISP2 DN Glucose analogue DMLISP2 MI TTYXA6Z DMLISP2 MN Plasmodium Hexose transporter 1 (Malaria ht1) DMLISP2 MT DTT DMLISP2 MA Binder DMLISP2 RN Opportunities and challenges in antiparasitic drug discovery. Nat Rev Drug Discov. 2005 Sep;4(9):727-40. DMLISP2 RU https://pubmed.ncbi.nlm.nih.gov/16138106 DMMJQ7O DI DMMJQ7O DMMJQ7O DN Glucose-bisphosphate DMMJQ7O MI DESR17C DMMJQ7O MN L-Lactate dehydrogenase (ldh) DMMJQ7O MT DME DMMJQ7O MA Metabolism DMMJQ7O RN Purification, properties and immunological relationship of L (+)-lactate dehydrogenase from Lactobacillus casei. Eur J Biochem. 1976 Aug 16;67(2):543-55. DMMJQ7O RU https://pubmed.ncbi.nlm.nih.gov/823016 DMXBQRJ DI DMXBQRJ DMXBQRJ DN Glu-Leu-Asp-Leu-(CHOH-CH2)-Ala-Ala-Glu-Phe DMXBQRJ MI TT8JRS7 DMXBQRJ MN Beta-secretase (BACE) DMXBQRJ MT DTT DMXBQRJ MA Inhibitor DMXBQRJ RN Efficient evaluation of binding free energy using continuum electrostatics solvation. J Med Chem. 2004 Nov 4;47(23):5791-7. DMXBQRJ RU https://pubmed.ncbi.nlm.nih.gov/15509178 DM6EA9B DI DM6EA9B DM6EA9B DN Glu-Pro-Gln-F2Pmp-Glu-Glu-Ile-Pro-Ile-Tyr-Leu DM6EA9B MI TT6PKBN DM6EA9B MN Proto-oncogene c-Src (SRC) DM6EA9B MT DTT DM6EA9B MA Inhibitor DM6EA9B RN The Role of 4-phosphonodifluoromethyl- and 4-phosphono-phenylalanine in the selectivity and cellular uptake of SH2 domain ligands, Bioorg. Med. Chem. Lett. 7(14):1909-1914 (1997). DM6EA9B RU http://www.sciencedirect.com/science/article/pii/S0960894X9700334X DMYZO37 DI DMYZO37 DMYZO37 DN Glu-Pro-Gln-pTyr-Glu-Glu-Ile-Pro-Ile-Tyr-Leu DMYZO37 MI TT6PKBN DMYZO37 MN Proto-oncogene c-Src (SRC) DMYZO37 MT DTT DMYZO37 MA Inhibitor DMYZO37 RN The Role of 4-phosphonodifluoromethyl- and 4-phosphono-phenylalanine in the selectivity and cellular uptake of SH2 domain ligands, Bioorg. Med. Chem. Lett. 7(14):1909-1914 (1997). DMYZO37 RU http://www.sciencedirect.com/science/article/pii/S0960894X9700334X DMT7K0U DI DMT7K0U DMT7K0U DN Glutamine Hydroxamate DMT7K0U MI TTC67I0 DMT7K0U MN Bacterial Glucosamine-6-phosphate synthase (Bact glmS) DMT7K0U MT DTT DMT7K0U MA Inhibitor DMT7K0U RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMT7K0U RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMPUFDS DI DMPUFDS DMPUFDS DN Glutarate DMPUFDS MI DTQ23VB DMPUFDS MN Organic anion transporter 1 (SLC22A6) DMPUFDS MT DTP DMPUFDS MA Substrate DMPUFDS RN Fluorescence-based assay for the interaction of small molecules with the human renal organic anion transporter 1. Anal Biochem. 2000 Jul 15;283(1):49-55. DMPUFDS RU http://www.ncbi.nlm.nih.gov/pubmed/10929807 DMPUFDS DI DMPUFDS DMPUFDS DN Glutarate DMPUFDS MI TTTQR47 DMPUFDS MN Solute carrier family 22 member 8 (SLC22A8) DMPUFDS MT DTT DMPUFDS MA Inhibitor DMPUFDS RN Structural variation governs substrate specificity for organic anion transporter (OAT) homologs. Potential remote sensing by OAT family members. J Biol Chem. 2007 Aug 17;282(33):23841-53. DMPUFDS RU https://pubmed.ncbi.nlm.nih.gov/17553798 DMAV2I7 DI DMAV2I7 DMAV2I7 DN Glutathione ester DMAV2I7 MI DEPT1ME DMAV2I7 MN Gamma-glutamyltranspeptidase 1 (GGT1) DMAV2I7 MT DME DMAV2I7 MA Metabolism DMAV2I7 RN Gamma-glutamyl compounds: substrate specificity of gamma-glutamyl transpeptidase enzymes. Anal Biochem. 2011 Jul 15;414(2):208-14. DMAV2I7 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=21447318 DMAV2I7 DI DMAV2I7 DMAV2I7 DN Glutathione ester DMAV2I7 MI DEH6CAO DMAV2I7 MN Gamma-glutamyltranspeptidase 5 (GGT5) DMAV2I7 MT DME DMAV2I7 MA Metabolism DMAV2I7 RN Gamma-glutamyl compounds: substrate specificity of gamma-glutamyl transpeptidase enzymes. Anal Biochem. 2011 Jul 15;414(2):208-14. DMAV2I7 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=21447318 DMPX7FR DI DMPX7FR DMPX7FR DN Glutathionylspermidine Disulfide DMPX7FR MI TTEP6RV DMPX7FR MN Glutathione reductase (GR) DMPX7FR MT DTT DMPX7FR MA Inhibitor DMPX7FR RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMPX7FR RU https://pubmed.ncbi.nlm.nih.gov/17139284 DM1Q83B DI DM1Q83B DM1Q83B DN Glu-Trp-Pro-Arg-Pro-Gln-Ile-Pro-Pro DM1Q83B MI TTB2MXP DM1Q83B MN Angiotensinogenase renin (REN) DM1Q83B MT DTT DM1Q83B MA Inhibitor DM1Q83B RN Inhibition of the renin-angiotensin system. A new approach to the therapy of hypertension. J Med Chem. 1981 Apr;24(4):355-61. DM1Q83B RU https://pubmed.ncbi.nlm.nih.gov/6267277 DMO8LAC DI DMO8LAC DMO8LAC DN Gly-Amp-Glu DMO8LAC MI TTLD29N DMO8LAC MN Glutamate receptor ionotropic NMDA 1 (NMDAR1) DMO8LAC MT DTT DMO8LAC MA Inhibitor DMO8LAC RN New Gly-Pro-Glu (GPE) analogues: expedite solid-phase synthesis and biological activity. Bioorg Med Chem Lett. 2006 Mar 1;16(5):1392-6. DMO8LAC RU https://pubmed.ncbi.nlm.nih.gov/16321525 DMO8LAC DI DMO8LAC DMO8LAC DN Gly-Amp-Glu DMO8LAC MI TTKJEMQ DMO8LAC MN Glutamate receptor ionotropic NMDA 2A (NMDAR2A) DMO8LAC MT DTT DMO8LAC MA Inhibitor DMO8LAC RN New Gly-Pro-Glu (GPE) analogues: expedite solid-phase synthesis and biological activity. Bioorg Med Chem Lett. 2006 Mar 1;16(5):1392-6. DMO8LAC RU https://pubmed.ncbi.nlm.nih.gov/16321525 DMO8LAC DI DMO8LAC DMO8LAC DN Gly-Amp-Glu DMO8LAC MI TTN9D8E DMO8LAC MN Glutamate receptor ionotropic NMDA 2B (NMDAR2B) DMO8LAC MT DTT DMO8LAC MA Inhibitor DMO8LAC RN New Gly-Pro-Glu (GPE) analogues: expedite solid-phase synthesis and biological activity. Bioorg Med Chem Lett. 2006 Mar 1;16(5):1392-6. DMO8LAC RU https://pubmed.ncbi.nlm.nih.gov/16321525 DMACT8D DI DMACT8D DMACT8D DN Gly-Arg-Gly-Asp-Ser DMACT8D MI TTT1R2L DMACT8D MN Integrin alpha-V (ITGAV) DMACT8D MT DTT DMACT8D MA Inhibitor DMACT8D RN alphavbeta3 Integrin-targeting Arg-Gly-Asp (RGD) peptidomimetics containing oligoethylene glycol (OEG) spacers. J Med Chem. 2009 Nov 26;52(22):7029-43. DMACT8D RU https://pubmed.ncbi.nlm.nih.gov/19860432 DMACT8D DI DMACT8D DMACT8D DN Gly-Arg-Gly-Asp-Ser DMACT8D MI TTJA1ZO DMACT8D MN ITGB3 messenger RNA (ITGB3 mRNA) DMACT8D MT DTT DMACT8D MA Inhibitor DMACT8D RN alphavbeta3 Integrin-targeting Arg-Gly-Asp (RGD) peptidomimetics containing oligoethylene glycol (OEG) spacers. J Med Chem. 2009 Nov 26;52(22):7029-43. DMACT8D RU https://pubmed.ncbi.nlm.nih.gov/19860432 DMGOIME DI DMGOIME DMGOIME DN Gly-Arg-Gly-Asp-Ser-Pro-Lys DMGOIME MI TTT1R2L DMGOIME MN Integrin alpha-V (ITGAV) DMGOIME MT DTT DMGOIME MA Inhibitor DMGOIME RN N-Methylated cyclic RGD peptides as highly active and selective alpha(V)beta(3) integrin antagonists. J Med Chem. 1999 Aug 12;42(16):3033-40. DMGOIME RU https://pubmed.ncbi.nlm.nih.gov/10447947 DMGOIME DI DMGOIME DMGOIME DN Gly-Arg-Gly-Asp-Ser-Pro-Lys DMGOIME MI TTJA1ZO DMGOIME MN ITGB3 messenger RNA (ITGB3 mRNA) DMGOIME MT DTT DMGOIME MA Inhibitor DMGOIME RN N-Methylated cyclic RGD peptides as highly active and selective alpha(V)beta(3) integrin antagonists. J Med Chem. 1999 Aug 12;42(16):3033-40. DMGOIME RU https://pubmed.ncbi.nlm.nih.gov/10447947 DM8L09J DI DM8L09J DM8L09J DN Gly-b7Pro-Glu DM8L09J MI TTLD29N DM8L09J MN Glutamate receptor ionotropic NMDA 1 (NMDAR1) DM8L09J MT DTT DM8L09J MA Inhibitor DM8L09J RN New Gly-Pro-Glu (GPE) analogues: expedite solid-phase synthesis and biological activity. Bioorg Med Chem Lett. 2006 Mar 1;16(5):1392-6. DM8L09J RU https://pubmed.ncbi.nlm.nih.gov/16321525 DM8L09J DI DM8L09J DM8L09J DN Gly-b7Pro-Glu DM8L09J MI TTKJEMQ DM8L09J MN Glutamate receptor ionotropic NMDA 2A (NMDAR2A) DM8L09J MT DTT DM8L09J MA Inhibitor DM8L09J RN New Gly-Pro-Glu (GPE) analogues: expedite solid-phase synthesis and biological activity. Bioorg Med Chem Lett. 2006 Mar 1;16(5):1392-6. DM8L09J RU https://pubmed.ncbi.nlm.nih.gov/16321525 DM8L09J DI DM8L09J DM8L09J DN Gly-b7Pro-Glu DM8L09J MI TTN9D8E DM8L09J MN Glutamate receptor ionotropic NMDA 2B (NMDAR2B) DM8L09J MT DTT DM8L09J MA Inhibitor DM8L09J RN New Gly-Pro-Glu (GPE) analogues: expedite solid-phase synthesis and biological activity. Bioorg Med Chem Lett. 2006 Mar 1;16(5):1392-6. DM8L09J RU https://pubmed.ncbi.nlm.nih.gov/16321525 DM0J5KF DI DM0J5KF DM0J5KF DN Glycerol-2-Phosphate DM0J5KF MI TTNS6X4 DM0J5KF MN Bacterial Triosephosphate isomerase (Bact TPI) DM0J5KF MT DTT DM0J5KF MA Inhibitor DM0J5KF RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DM0J5KF RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMTCEFV DI DMTCEFV DMTCEFV DN Glycinamid DMTCEFV MI TTGA1IV DMTCEFV MN Matrix metalloproteinase-8 (MMP-8) DMTCEFV MT DTT DMTCEFV MA Inhibitor DMTCEFV RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMTCEFV RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMW180Y DI DMW180Y DMW180Y DN Glycinamide Ribonucleotide DMW180Y MI TTEXB9Z DMW180Y MN Glycinamide ribonucleotide formyltransferase (GART) DMW180Y MT DTT DMW180Y MA Inhibitor DMW180Y RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMW180Y RU https://pubmed.ncbi.nlm.nih.gov/17139284 DM0SXNM DI DM0SXNM DM0SXNM DN Glycocholic acid DM0SXNM MI DTI7UX6 DM0SXNM MN Breast cancer resistance protein (ABCG2) DM0SXNM MT DTP DM0SXNM MA Substrate DM0SXNM RN Characterization of the role of ABCG2 as a bile acid transporter in liver and placenta. Mol Pharmacol. 2012 Feb;81(2):273-83. DM0SXNM RU https://doi.org/10.1124/mol.111.075143 DM0SXNM DI DM0SXNM DM0SXNM DN Glycocholic acid DM0SXNM MI DTFI42L DM0SXNM MN Multidrug resistance-associated protein 2 (ABCC2) DM0SXNM MT DTP DM0SXNM MA Substrate DM0SXNM RN Differential modulation of the human liver conjugate transporters MRP2 and MRP3 by bile acids and organic anions. J Biol Chem. 2003 Jun 27;278(26):23529-37. DM0SXNM RU https://doi.org/10.1074/jbc.M303515200 DM0SXNM DI DM0SXNM DM0SXNM DN Glycocholic acid DM0SXNM MI DTQ3ZHF DM0SXNM MN Multidrug resistance-associated protein 3 (ABCC3) DM0SXNM MT DTP DM0SXNM MA Substrate DM0SXNM RN Measurement of transport activities of bile acids in human multidrug resistance-associated protein 3 using liquid chromatography-tandem mass spectrometry. Anal Sci. 2010;26(3):317-23. DM0SXNM RU https://doi.org/10.2116/analsci.26.317 DM0SXNM DI DM0SXNM DM0SXNM DN Glycocholic acid DM0SXNM MI DTCSGPB DM0SXNM MN Multidrug resistance-associated protein 4 (ABCC4) DM0SXNM MT DTP DM0SXNM MA Substrate DM0SXNM RN Human intestinal transporter database: QSAR modeling and virtual profiling of drug uptake, efflux and interactions. Pharm Res. 2013 Apr;30(4):996-1007. DM0SXNM RU https://doi.org/10.1007/s11095-012-0935-x DM0SXNM DI DM0SXNM DM0SXNM DN Glycocholic acid DM0SXNM MI DTE2B1D DM0SXNM MN Organic anion transporting polypeptide 1A2 (SLCO1A2) DM0SXNM MT DTP DM0SXNM MA Substrate DM0SXNM RN Organic anion-transporting polypeptide B (OATP-B) and its functional comparison with three other OATPs of human liver. Gastroenterology. 2001 Feb;120(2):525-33. DM0SXNM RU http://www.ncbi.nlm.nih.gov/pubmed/11159893 DM0SXNM DI DM0SXNM DM0SXNM DN Glycocholic acid DM0SXNM MI DT3D8F0 DM0SXNM MN Organic anion transporting polypeptide 1B1 (SLCO1B1) DM0SXNM MT DTP DM0SXNM MA Substrate DM0SXNM RN Organic anion transporting polypeptide 1B1: a genetically polymorphic transporter of major importance for hepatic drug uptake. Pharmacol Rev. 2011 Mar;63(1):157-81. DM0SXNM RU http://www.ncbi.nlm.nih.gov/pubmed/21245207 DM0SXNM DI DM0SXNM DM0SXNM DN Glycocholic acid DM0SXNM MI DT9C1TS DM0SXNM MN Organic anion transporting polypeptide 1B3 (SLCO1B3) DM0SXNM MT DTP DM0SXNM MA Substrate DM0SXNM RN Organic anion-transporting polypeptide B (OATP-B) and its functional comparison with three other OATPs of human liver. Gastroenterology. 2001 Feb;120(2):525-33. DM0SXNM RU http://www.ncbi.nlm.nih.gov/pubmed/11159893 DM1XEJV DI DM1XEJV DM1XEJV DN Glycodeoxycholic acid DM1XEJV MI DT7JELC DM1XEJV MN Apical sodium-dependent bile acid transporter (SLC10A2) DM1XEJV MT DTP DM1XEJV MA Substrate DM1XEJV RN Expression and transport properties of the human ileal and renal sodium-dependent bile acid transporter. Am J Physiol. 1998 Jan;274(1):G157-69. DM1XEJV RU http://ajpgi.physiology.org/content/274/1/G157.long DM1XEJV DI DM1XEJV DM1XEJV DN Glycodeoxycholic acid DM1XEJV MI DTCSGPB DM1XEJV MN Multidrug resistance-associated protein 4 (ABCC4) DM1XEJV MT DTP DM1XEJV MA Substrate DM1XEJV RN Human intestinal transporter database: QSAR modeling and virtual profiling of drug uptake, efflux and interactions. Pharm Res. 2013 Apr;30(4):996-1007. DM1XEJV RU https://doi.org/10.1007/s11095-012-0935-x DM0SCK8 DI DM0SCK8 DM0SCK8 DN Glycyl-H 1152 DM0SCK8 MI TTLYXIT DM0SCK8 MN Aurora kinase C (AURKC) DM0SCK8 MT DTT DM0SCK8 MA Inhibitor DM0SCK8 RN Development of specific Rho-kinase inhibitors and their clinical application. Biochim Biophys Acta. 2005 Dec 30;1754(1-2):245-52. DM0SCK8 RU https://pubmed.ncbi.nlm.nih.gov/16213195 DM0SCK8 DI DM0SCK8 DM0SCK8 DN Glycyl-H 1152 DM0SCK8 MI TTGWKQJ DM0SCK8 MN Rho-associated protein kinase 2 (ROCK2) DM0SCK8 MT DTT DM0SCK8 MA Inhibitor DM0SCK8 RN Development of specific Rho-kinase inhibitors and their clinical application. Biochim Biophys Acta. 2005 Dec 30;1754(1-2):245-52. DM0SCK8 RU https://pubmed.ncbi.nlm.nih.gov/16213195 DM8FTJN DI DM8FTJN DM8FTJN DN Glycyl-L-Alpha-Amino-Epsilon-Pimelyl-D-Alanine DM8FTJN MI TTLP6GN DM8FTJN MN Bacterial DD-carboxypeptidase (Bact vanYB) DM8FTJN MT DTT DM8FTJN MA Inhibitor DM8FTJN RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DM8FTJN RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMTOCXZ DI DMTOCXZ DMTOCXZ DN GLYCYLRYANODINE DMTOCXZ MI TTU5CIX DMTOCXZ MN Ryanodine receptor 1 (RYR1) DMTOCXZ MT DTT DMTOCXZ MA Inhibitor DMTOCXZ RN Amino- and guanidinoacylryanodines: basic ryanodine esters with enhanced affinity for the sarcoplasmic reticulum Ca(2+)-release channel. J Med Chem. 1993 May 14;36(10):1319-23. DMTOCXZ RU https://pubmed.ncbi.nlm.nih.gov/8388466 DM67FQ1 DI DM67FQ1 DM67FQ1 DN GlyH-101 DM67FQ1 MI TTRLZHP DM67FQ1 MN cAMP-dependent chloride channel (CFTR) DM67FQ1 MT DTT DM67FQ1 MA Blocker (channel blocker) DM67FQ1 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 707). DM67FQ1 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=707 DM8XR4Y DI DM8XR4Y DM8XR4Y DN Gly-Hyp-Glu DM8XR4Y MI TTLD29N DM8XR4Y MN Glutamate receptor ionotropic NMDA 1 (NMDAR1) DM8XR4Y MT DTT DM8XR4Y MA Inhibitor DM8XR4Y RN New Gly-Pro-Glu (GPE) analogues: expedite solid-phase synthesis and biological activity. Bioorg Med Chem Lett. 2006 Mar 1;16(5):1392-6. DM8XR4Y RU https://pubmed.ncbi.nlm.nih.gov/16321525 DM8XR4Y DI DM8XR4Y DM8XR4Y DN Gly-Hyp-Glu DM8XR4Y MI TTKJEMQ DM8XR4Y MN Glutamate receptor ionotropic NMDA 2A (NMDAR2A) DM8XR4Y MT DTT DM8XR4Y MA Inhibitor DM8XR4Y RN New Gly-Pro-Glu (GPE) analogues: expedite solid-phase synthesis and biological activity. Bioorg Med Chem Lett. 2006 Mar 1;16(5):1392-6. DM8XR4Y RU https://pubmed.ncbi.nlm.nih.gov/16321525 DM8XR4Y DI DM8XR4Y DM8XR4Y DN Gly-Hyp-Glu DM8XR4Y MI TTN9D8E DM8XR4Y MN Glutamate receptor ionotropic NMDA 2B (NMDAR2B) DM8XR4Y MT DTT DM8XR4Y MA Inhibitor DM8XR4Y RN New Gly-Pro-Glu (GPE) analogues: expedite solid-phase synthesis and biological activity. Bioorg Med Chem Lett. 2006 Mar 1;16(5):1392-6. DM8XR4Y RU https://pubmed.ncbi.nlm.nih.gov/16321525 DMQUP7O DI DMQUP7O DMQUP7O DN Glyoxalate, Glyoxylate DMQUP7O MI TT58ZYW DMQUP7O MN Mycobacterium Isocitrate lyase (MycB icl) DMQUP7O MT DTT DMQUP7O MA Inhibitor DMQUP7O RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMQUP7O RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMJ9XZO DI DMJ9XZO DMJ9XZO DN Glyoxylate DMJ9XZO MI DER5HFI DMJ9XZO MN Alanine aminotransferase 1 (GPT) DMJ9XZO MT DME DMJ9XZO MA Metabolism DMJ9XZO RN Recombinant production of eight human cytosolic aminotransferases and assessment of their potential involvement in glyoxylate metabolism. Biochem J. 2009 Aug 13;422(2):265-72. DMJ9XZO RU https://www.ncbi.nlm.nih.gov/pubmed/?term=19545238 DMJ9XZO DI DMJ9XZO DMJ9XZO DN Glyoxylate DMJ9XZO MI DEBS17P DMJ9XZO MN Phosphoserine aminotransferase (PSAT1) DMJ9XZO MT DME DMJ9XZO MA Metabolism DMJ9XZO RN Recombinant production of eight human cytosolic aminotransferases and assessment of their potential involvement in glyoxylate metabolism. Biochem J. 2009 Aug 13;422(2):265-72. DMJ9XZO RU https://www.ncbi.nlm.nih.gov/pubmed/?term=19545238 DM0AFY7 DI DM0AFY7 DM0AFY7 DN Glyphosate DM0AFY7 MI TTB30PF DM0AFY7 MN Bacterial Phosphoshikimate1-carboxyvinyltransferase (Bact aroA) DM0AFY7 MT DTT DM0AFY7 MA Inhibitor DM0AFY7 RN Novel molecular targets for antimalarial chemotherapy. Int J Antimicrob Agents. 2007 Jul;30(1):4-10. DM0AFY7 RU https://pubmed.ncbi.nlm.nih.gov/17339102 DM0AFY7 DI DM0AFY7 DM0AFY7 DN Glyphosate DM0AFY7 MI TTVL895 DM0AFY7 MN Plasmodium Enopyruvyl shikimate phosphate synthase (Malaria ESPS) DM0AFY7 MT DTT DM0AFY7 MA Inhibitor DM0AFY7 RN The apicoplast as an antimalarial drug target. Drug Resist Updat. 2001 Jun;4(3):145-51. DM0AFY7 RU https://pubmed.ncbi.nlm.nih.gov/11768328 DMM0JA4 DI DMM0JA4 DMM0JA4 DN Gly-Pip-Glu DMM0JA4 MI TTLD29N DMM0JA4 MN Glutamate receptor ionotropic NMDA 1 (NMDAR1) DMM0JA4 MT DTT DMM0JA4 MA Inhibitor DMM0JA4 RN New Gly-Pro-Glu (GPE) analogues: expedite solid-phase synthesis and biological activity. Bioorg Med Chem Lett. 2006 Mar 1;16(5):1392-6. DMM0JA4 RU https://pubmed.ncbi.nlm.nih.gov/16321525 DMM0JA4 DI DMM0JA4 DMM0JA4 DN Gly-Pip-Glu DMM0JA4 MI TTKJEMQ DMM0JA4 MN Glutamate receptor ionotropic NMDA 2A (NMDAR2A) DMM0JA4 MT DTT DMM0JA4 MA Inhibitor DMM0JA4 RN New Gly-Pro-Glu (GPE) analogues: expedite solid-phase synthesis and biological activity. Bioorg Med Chem Lett. 2006 Mar 1;16(5):1392-6. DMM0JA4 RU https://pubmed.ncbi.nlm.nih.gov/16321525 DMM0JA4 DI DMM0JA4 DMM0JA4 DN Gly-Pip-Glu DMM0JA4 MI TTN9D8E DMM0JA4 MN Glutamate receptor ionotropic NMDA 2B (NMDAR2B) DMM0JA4 MT DTT DMM0JA4 MA Inhibitor DMM0JA4 RN New Gly-Pro-Glu (GPE) analogues: expedite solid-phase synthesis and biological activity. Bioorg Med Chem Lett. 2006 Mar 1;16(5):1392-6. DMM0JA4 RU https://pubmed.ncbi.nlm.nih.gov/16321525 DMMDU0K DI DMMDU0K DMMDU0K DN GM-109 DMMDU0K MI TT953CX DMMDU0K MN Motilin receptor (MLNR) DMMDU0K MT DTT DMMDU0K MA Antagonist DMMDU0K RN Design and synthesis of motilin antagonists derived from the [1-4] fragment of porcine motilin. J Med Chem. 2002 Jan 31;45(3):670-5. DMMDU0K RU https://pubmed.ncbi.nlm.nih.gov/11806718 DMM0ZKQ DI DMM0ZKQ DMM0ZKQ DN GMQ DMM0ZKQ MI TTLGDIS DMM0ZKQ MN Acid-sensing ion channel 3 (ASIC3) DMM0ZKQ MT DTT DMM0ZKQ MA Activator DMM0ZKQ RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 686). DMM0ZKQ RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=686 DMYWM56 DI DMYWM56 DMYWM56 DN GNE-7915 DMYWM56 MI TTP7EGM DMYWM56 MN Dual specificity protein kinase TTK (MPS1) DMYWM56 MT DTT DMYWM56 MA Inhibitor DMYWM56 RN Discovery of highly potent, selective, and brain-penetrant aminopyrazole leucine-rich repeat kinase 2 (LRRK2) small molecule inhibitors. J Med Chem. 2014 Feb 13;57(3):921-36. DMYWM56 RU https://pubmed.ncbi.nlm.nih.gov/24354345 DMYWM56 DI DMYWM56 DMYWM56 DN GNE-7915 DMYWM56 MI TTK0FEA DMYWM56 MN Leucine-rich repeat kinase 2 (LRRK2) DMYWM56 MT DTT DMYWM56 MA Inhibitor DMYWM56 RN Discovery of highly potent, selective, and brain-penetrant aminopyrazole leucine-rich repeat kinase 2 (LRRK2) small molecule inhibitors. J Med Chem. 2014 Feb 13;57(3):921-36. DMYWM56 RU https://pubmed.ncbi.nlm.nih.gov/24354345 DMLXR90 DI DMLXR90 DMLXR90 DN GNE-9605 DMLXR90 MI TTK0FEA DMLXR90 MN Leucine-rich repeat kinase 2 (LRRK2) DMLXR90 MT DTT DMLXR90 MA Inhibitor DMLXR90 RN Discovery of highly potent, selective, and brain-penetrant aminopyrazole leucine-rich repeat kinase 2 (LRRK2) small molecule inhibitors. J Med Chem. 2014 Feb 13;57(3):921-36. DMLXR90 RU https://pubmed.ncbi.nlm.nih.gov/24354345 DMGLIPV DI DMGLIPV DMGLIPV DN GNF-5 DMGLIPV MI TT6B75U DMGLIPV MN ABL messenger RNA (ABL mRNA) DMGLIPV MT DTT DMGLIPV MA Inhibitor DMGLIPV RN Targeting Bcr-Abl by combining allosteric with ATP-binding-site inhibitors. Nature. 2010 Jan 28;463(7280):501-6. DMGLIPV RU https://pubmed.ncbi.nlm.nih.gov/20072125 DMYJO13 DI DMYJO13 DMYJO13 DN GNF-5837 DMYJO13 MI TTKN7QR DMYJO13 MN BDNF/NT-3 growth factors receptor (TrkB) DMYJO13 MT DTT DMYJO13 MA Inhibitor DMYJO13 RN Discovery of GNF-5837, a Selective TRK Inhibitor with Efficacy in Rodent Cancer Tumor Models. ACS Med Chem Lett. 2012 Jan 1;3(2):140-5. DMYJO13 RU https://pubmed.ncbi.nlm.nih.gov/24900443 DMYJO13 DI DMYJO13 DMYJO13 DN GNF-5837 DMYJO13 MI TTXABCW DMYJO13 MN NT-3 growth factor receptor (TrkC) DMYJO13 MT DTT DMYJO13 MA Inhibitor DMYJO13 RN Discovery of GNF-5837, a Selective TRK Inhibitor with Efficacy in Rodent Cancer Tumor Models. ACS Med Chem Lett. 2012 Jan 1;3(2):140-5. DMYJO13 RU https://pubmed.ncbi.nlm.nih.gov/24900443 DM3INUK DI DM3INUK DM3INUK DN GNF-PF-117 DM3INUK MI TTML2WA DM3INUK MN Tubulin (TUB) DM3INUK MT DTT DM3INUK MA Inhibitor DM3INUK RN Synthesis and cytotoxicity of 1,6,7,8-substituted 2-(4'-substituted phenyl)-4-quinolones and related compounds: identification as antimitotic agent... J Med Chem. 1993 Apr 30;36(9):1146-56. DM3INUK RU https://pubmed.ncbi.nlm.nih.gov/8387598 DM3INUK DI DM3INUK DM3INUK DN GNF-PF-117 DM3INUK MI TTYFKSZ DM3INUK MN Tubulin beta (TUBB) DM3INUK MT DTT DM3INUK MA Inhibitor DM3INUK RN Synthesis and cytotoxicity of 1,6,7,8-substituted 2-(4'-substituted phenyl)-4-quinolones and related compounds: identification as antimitotic agent... J Med Chem. 1993 Apr 30;36(9):1146-56. DM3INUK RU https://pubmed.ncbi.nlm.nih.gov/8387598 DM183RV DI DM183RV DM183RV DN GNF-PF-1399 DM183RV MI TTH8FZW DM183RV MN Signal transducer and activator of transcription 3 (STAT3) DM183RV MT DTT DM183RV MA Inhibitor DM183RV RN In silico identification and biochemical evaluation of novel inhibitors of NRH:quinone oxidoreductase 2 (NQO2). Bioorg Med Chem Lett. 2010 Dec 15;20(24):7331-6. DM183RV RU https://pubmed.ncbi.nlm.nih.gov/21074425 DMVUBGF DI DMVUBGF DMVUBGF DN GNF-PF-1550 DMVUBGF MI TTX4RTB DMVUBGF MN Melanin-concentrating hormone receptor 1 (MCHR1) DMVUBGF MT DTT DMVUBGF MA Inhibitor DMVUBGF RN 6-Acylamino-2-aminoquinolines as potent melanin-concentrating hormone 1 receptor antagonists. Identification, structure-activity relationship, and ... J Med Chem. 2005 Sep 8;48(18):5684-97. DMVUBGF RU https://pubmed.ncbi.nlm.nih.gov/16134937 DMHCGBZ DI DMHCGBZ DMHCGBZ DN GNF-PF-1591 DMHCGBZ MI TTL53M6 DMHCGBZ MN Induced myeloid leukemia cell differentiation protein Mcl-1 (MCL1) DMHCGBZ MT DTT DMHCGBZ MA Inhibitor DMHCGBZ RN In silico identification and biochemical evaluation of novel inhibitors of NRH:quinone oxidoreductase 2 (NQO2). Bioorg Med Chem Lett. 2010 Dec 15;20(24):7331-6. DMHCGBZ RU https://pubmed.ncbi.nlm.nih.gov/21074425 DM4JZ9A DI DM4JZ9A DM4JZ9A DN GNF-PF-1694 DM4JZ9A MI TT2CJVK DM4JZ9A MN Adrenergic receptor beta-2 (ADRB2) DM4JZ9A MT DTT DM4JZ9A MA Inhibitor DM4JZ9A RN Use of the X-ray structure of the beta2-adrenergic receptor for drug discovery. Part 2: Identification of active compounds. Bioorg Med Chem Lett. 2008 Oct 15;18(20):5391-5. DM4JZ9A RU https://pubmed.ncbi.nlm.nih.gov/18829308 DMUSAYG DI DMUSAYG DMUSAYG DN GNF-PF-173 DMUSAYG MI TT9SL3Q DMUSAYG MN Polypeptide deformylase (PDF) DMUSAYG MT DTT DMUSAYG MA Inhibitor DMUSAYG RN Synthesis and biological evaluation of poly-gamma-glutamyl metabolites of 10-deazaaminopterin and 10-ethyl-10-deazaaminopterin. J Med Chem. 1988 Jan;31(1):181-5. DMUSAYG RU https://pubmed.ncbi.nlm.nih.gov/2447278 DMGSRLA DI DMGSRLA DMGSRLA DN GNF-PF-1967 DMGSRLA MI TTZPWGN DMGSRLA MN Voltage-gated calcium channel alpha Cav3.2 (CACNA1H) DMGSRLA MT DTT DMGSRLA MA Inhibitor DMGSRLA RN 3D pharmacophore based virtual screening of T-type calcium channel blockers. Bioorg Med Chem. 2007 Jan 15;15(2):1091-105. DMGSRLA RU https://pubmed.ncbi.nlm.nih.gov/17074493 DM9J35R DI DM9J35R DM9J35R DN GNF-PF-2094 DM9J35R MI TTVG215 DM9J35R MN Debrisoquine 4-hydroxylase (CYP2D6) DM9J35R MT DTT DM9J35R MA Inhibitor DM9J35R RN Synthesis and antiplasmodial activity of novel 2,4-diaminopyrimidines. Bioorg Med Chem Lett. 2010 Jan 1;20(1):228-31. DM9J35R RU https://pubmed.ncbi.nlm.nih.gov/19914064 DM26UKN DI DM26UKN DM26UKN DN GNF-PF-2224 DM26UKN MI TTK25J1 DM26UKN MN Adenosine A1 receptor (ADORA1) DM26UKN MT DTT DM26UKN MA Inhibitor DM26UKN RN Minoxidil-induced hair growth is mediated by adenosine in cultured dermal papilla cells: possible involvement of sulfonylurea receptor 2B as a target of minoxidil. J Invest Dermatol. 2001 Dec;117(6):1594-600. DM26UKN RU https://pubmed.ncbi.nlm.nih.gov/11886528 DM26UKN DI DM26UKN DM26UKN DN GNF-PF-2224 DM26UKN MI TTM2AOE DM26UKN MN Adenosine A2a receptor (ADORA2A) DM26UKN MT DTT DM26UKN MA Inhibitor DM26UKN RN Synthesis and theoretical studies on energetics of novel N- and O- perfluoroalkyl triazole tagged thienopyrimidines--their potential as adenosine r... Eur J Med Chem. 2010 May;45(5):1739-45. DM26UKN RU https://pubmed.ncbi.nlm.nih.gov/20116907 DM26UKN DI DM26UKN DM26UKN DN GNF-PF-2224 DM26UKN MI TTNE7KG DM26UKN MN Adenosine A2b receptor (ADORA2B) DM26UKN MT DTT DM26UKN MA Inhibitor DM26UKN RN Discovery of FK453, a novel non-xanthine adenosine A1 receptor antagonist, Bioorg. Med. Chem. Lett. 6(17):2059-2062 (1996). DM26UKN RU http://www.sciencedirect.com/science/article/pii/0960894X9600368X DM26UKN DI DM26UKN DM26UKN DN GNF-PF-2224 DM26UKN MI TTJFY5U DM26UKN MN Adenosine A3 receptor (ADORA3) DM26UKN MT DTT DM26UKN MA Inhibitor DM26UKN RN Pyrazolo[1',5':1,6]pyrimido[4,5-d]pyridazin-4(3H)-ones as selective human A(1) adenosine receptor ligands. Bioorg Med Chem. 2010 Nov 15;18(22):7890-9. DM26UKN RU https://pubmed.ncbi.nlm.nih.gov/20937560 DM26UKN DI DM26UKN DM26UKN DN GNF-PF-2224 DM26UKN MI TTSLI08 DM26UKN MN Adenosine receptor (ADOR) DM26UKN MT DTT DM26UKN MA Antagonist DM26UKN RN Minoxidil-induced hair growth is mediated by adenosine in cultured dermal papilla cells: possible involvement of sulfonylurea receptor 2B as a target of minoxidil. J Invest Dermatol. 2001 Dec;117(6):1594-600. DM26UKN RU https://pubmed.ncbi.nlm.nih.gov/11886528 DMONK0F DI DMONK0F DMONK0F DN GNF-PF-2272 DMONK0F MI TT915ZD DMONK0F MN Candida Mannose-6-phosphate isomerase (Candi PMI1) DMONK0F MT DTT DMONK0F MA Inhibitor DMONK0F RN In silico identification and biochemical evaluation of novel inhibitors of NRH:quinone oxidoreductase 2 (NQO2). Bioorg Med Chem Lett. 2010 Dec 15;20(24):7331-6. DMONK0F RU https://pubmed.ncbi.nlm.nih.gov/21074425 DMONK0F DI DMONK0F DMONK0F DN GNF-PF-2272 DMONK0F MI TTHQZV7 DMONK0F MN Mothers against decapentaplegic homolog 3 (SMAD3) DMONK0F MT DTT DMONK0F MA Inhibitor DMONK0F RN In silico identification and biochemical evaluation of novel inhibitors of NRH:quinone oxidoreductase 2 (NQO2). Bioorg Med Chem Lett. 2010 Dec 15;20(24):7331-6. DMONK0F RU https://pubmed.ncbi.nlm.nih.gov/21074425 DMP6DBX DI DMP6DBX DMP6DBX DN GNF-PF-2307 DMP6DBX MI TT8DBY3 DMP6DBX MN Angiotensin II receptor type-1 (AGTR1) DMP6DBX MT DTT DMP6DBX MA Inhibitor DMP6DBX RN In silico identification and biochemical evaluation of novel inhibitors of NRH:quinone oxidoreductase 2 (NQO2). Bioorg Med Chem Lett. 2010 Dec 15;20(24):7331-6. DMP6DBX RU https://pubmed.ncbi.nlm.nih.gov/21074425 DMW93IO DI DMW93IO DMW93IO DN GNF-PF-2322 DMW93IO MI TTX4RTB DMW93IO MN Melanin-concentrating hormone receptor 1 (MCHR1) DMW93IO MT DTT DMW93IO MA Inhibitor DMW93IO RN 6-Acylamino-2-aminoquinolines as potent melanin-concentrating hormone 1 receptor antagonists. Identification, structure-activity relationship, and ... J Med Chem. 2005 Sep 8;48(18):5684-97. DMW93IO RU https://pubmed.ncbi.nlm.nih.gov/16134937 DMC56YJ DI DMC56YJ DMC56YJ DN GNF-PF-2700 DMC56YJ MI TTK25J1 DMC56YJ MN Adenosine A1 receptor (ADORA1) DMC56YJ MT DTT DMC56YJ MA Inhibitor DMC56YJ RN Insights into binding modes of adenosine A(2B) antagonists with ligand-based and receptor-based methods. Eur J Med Chem. 2010 Aug;45(8):3459-71. DMC56YJ RU https://pubmed.ncbi.nlm.nih.gov/20537438 DMC56YJ DI DMC56YJ DMC56YJ DN GNF-PF-2700 DMC56YJ MI TTM2AOE DMC56YJ MN Adenosine A2a receptor (ADORA2A) DMC56YJ MT DTT DMC56YJ MA Inhibitor DMC56YJ RN Insights into binding modes of adenosine A(2B) antagonists with ligand-based and receptor-based methods. Eur J Med Chem. 2010 Aug;45(8):3459-71. DMC56YJ RU https://pubmed.ncbi.nlm.nih.gov/20537438 DMC56YJ DI DMC56YJ DMC56YJ DN GNF-PF-2700 DMC56YJ MI TTNE7KG DMC56YJ MN Adenosine A2b receptor (ADORA2B) DMC56YJ MT DTT DMC56YJ MA Inhibitor DMC56YJ RN Insights into binding modes of adenosine A(2B) antagonists with ligand-based and receptor-based methods. Eur J Med Chem. 2010 Aug;45(8):3459-71. DMC56YJ RU https://pubmed.ncbi.nlm.nih.gov/20537438 DMD1QOH DI DMD1QOH DMD1QOH DN GNF-PF-2812 DMD1QOH MI TT8DBY3 DMD1QOH MN Angiotensin II receptor type-1 (AGTR1) DMD1QOH MT DTT DMD1QOH MA Inhibitor DMD1QOH RN In silico identification and biochemical evaluation of novel inhibitors of NRH:quinone oxidoreductase 2 (NQO2). Bioorg Med Chem Lett. 2010 Dec 15;20(24):7331-6. DMD1QOH RU https://pubmed.ncbi.nlm.nih.gov/21074425 DML5QFZ DI DML5QFZ DML5QFZ DN GNF-PF-2857 DML5QFZ MI TTWG9A4 DML5QFZ MN Adrenergic receptor alpha-2A (ADRA2A) DML5QFZ MT DTT DML5QFZ MA Inhibitor DML5QFZ RN Structure-activity relationship of quinoline derivatives as potent and selective alpha(2C)-adrenoceptor antagonists. J Med Chem. 2006 Oct 19;49(21):6351-63. DML5QFZ RU https://pubmed.ncbi.nlm.nih.gov/17034141 DML5QFZ DI DML5QFZ DML5QFZ DN GNF-PF-2857 DML5QFZ MI TTWM4TY DML5QFZ MN Adrenergic receptor alpha-2B (ADRA2B) DML5QFZ MT DTT DML5QFZ MA Inhibitor DML5QFZ RN Structure-activity relationship of quinoline derivatives as potent and selective alpha(2C)-adrenoceptor antagonists. J Med Chem. 2006 Oct 19;49(21):6351-63. DML5QFZ RU https://pubmed.ncbi.nlm.nih.gov/17034141 DML5QFZ DI DML5QFZ DML5QFZ DN GNF-PF-2857 DML5QFZ MI TT2NUT5 DML5QFZ MN Adrenergic receptor alpha-2C (ADRA2C) DML5QFZ MT DTT DML5QFZ MA Inhibitor DML5QFZ RN Structure-activity relationship of quinoline derivatives as potent and selective alpha(2C)-adrenoceptor antagonists. J Med Chem. 2006 Oct 19;49(21):6351-63. DML5QFZ RU https://pubmed.ncbi.nlm.nih.gov/17034141 DMLP241 DI DMLP241 DMLP241 DN GNF-PF-2893 DMLP241 MI TTT2SVW DMLP241 MN PPAR-gamma messenger RNA (PPARG mRNA) DMLP241 MT DTT DMLP241 MA Inhibitor DMLP241 RN In silico identification and biochemical evaluation of novel inhibitors of NRH:quinone oxidoreductase 2 (NQO2). Bioorg Med Chem Lett. 2010 Dec 15;20(24):7331-6. DMLP241 RU https://pubmed.ncbi.nlm.nih.gov/21074425 DM4RZSB DI DM4RZSB DM4RZSB DN GNF-PF-3037 DM4RZSB MI TTOM3J0 DM4RZSB MN Estrogen receptor beta (ESR2) DM4RZSB MT DTT DM4RZSB MA Inhibitor DM4RZSB RN In silico identification and biochemical evaluation of novel inhibitors of NRH:quinone oxidoreductase 2 (NQO2). Bioorg Med Chem Lett. 2010 Dec 15;20(24):7331-6. DM4RZSB RU https://pubmed.ncbi.nlm.nih.gov/21074425 DM4RZSB DI DM4RZSB DM4RZSB DN GNF-PF-3037 DM4RZSB MI TTT2SVW DM4RZSB MN PPAR-gamma messenger RNA (PPARG mRNA) DM4RZSB MT DTT DM4RZSB MA Inhibitor DM4RZSB RN In silico identification and biochemical evaluation of novel inhibitors of NRH:quinone oxidoreductase 2 (NQO2). Bioorg Med Chem Lett. 2010 Dec 15;20(24):7331-6. DM4RZSB RU https://pubmed.ncbi.nlm.nih.gov/21074425 DMWAKHD DI DMWAKHD DMWAKHD DN GNF-PF-3464 DMWAKHD MI TTWXB3E DMWAKHD MN Hepatitis C virus NS3 helicase (HCV NS3) DMWAKHD MT DTT DMWAKHD MA Inhibitor DMWAKHD RN In silico identification and biochemical evaluation of novel inhibitors of NRH:quinone oxidoreductase 2 (NQO2). Bioorg Med Chem Lett. 2010 Dec 15;20(24):7331-6. DMWAKHD RU https://pubmed.ncbi.nlm.nih.gov/21074425 DMWAKHD DI DMWAKHD DMWAKHD DN GNF-PF-3464 DMWAKHD MI TT4FDG6 DMWAKHD MN Voltage-gated calcium channel alpha Cav2.2 (CACNA1B) DMWAKHD MT DTT DMWAKHD MA Inhibitor DMWAKHD RN In silico identification and biochemical evaluation of novel inhibitors of NRH:quinone oxidoreductase 2 (NQO2). Bioorg Med Chem Lett. 2010 Dec 15;20(24):7331-6. DMWAKHD RU https://pubmed.ncbi.nlm.nih.gov/21074425 DM17GIV DI DM17GIV DM17GIV DN GNF-PF-3645 DM17GIV MI TT1MPAY DM17GIV MN GABA(A) receptor alpha-1 (GABRA1) DM17GIV MT DTT DM17GIV MA Inhibitor DM17GIV RN 4-quinolone derivatives: high-affinity ligands at the benzodiazepine site of brain GABA A receptors. synthesis, pharmacology, and pharmacophore mod... J Med Chem. 2006 Apr 20;49(8):2526-33. DM17GIV RU https://pubmed.ncbi.nlm.nih.gov/16610795 DM17GIV DI DM17GIV DM17GIV DN GNF-PF-3645 DM17GIV MI TTZA1NY DM17GIV MN GABA(A) receptor beta-2 (GABRB2) DM17GIV MT DTT DM17GIV MA Inhibitor DM17GIV RN 4-quinolone derivatives: high-affinity ligands at the benzodiazepine site of brain GABA A receptors. synthesis, pharmacology, and pharmacophore mod... J Med Chem. 2006 Apr 20;49(8):2526-33. DM17GIV RU https://pubmed.ncbi.nlm.nih.gov/16610795 DM17GIV DI DM17GIV DM17GIV DN GNF-PF-3645 DM17GIV MI TT06RH5 DM17GIV MN GABA(A) receptor gamma-2 (GABRG2) DM17GIV MT DTT DM17GIV MA Inhibitor DM17GIV RN 4-quinolone derivatives: high-affinity ligands at the benzodiazepine site of brain GABA A receptors. synthesis, pharmacology, and pharmacophore mod... J Med Chem. 2006 Apr 20;49(8):2526-33. DM17GIV RU https://pubmed.ncbi.nlm.nih.gov/16610795 DM17GIV DI DM17GIV DM17GIV DN GNF-PF-3645 DM17GIV MI TTNJYV2 DM17GIV MN Gamma-aminobutyric acid receptor (GAR) DM17GIV MT DTT DM17GIV MA Inhibitor DM17GIV RN 4-quinolone derivatives: high-affinity ligands at the benzodiazepine site of brain GABA A receptors. synthesis, pharmacology, and pharmacophore mod... J Med Chem. 2006 Apr 20;49(8):2526-33. DM17GIV RU https://pubmed.ncbi.nlm.nih.gov/16610795 DMIY79U DI DMIY79U DMIY79U DN GNF-PF-3832 DMIY79U MI TT8DBY3 DMIY79U MN Angiotensin II receptor type-1 (AGTR1) DMIY79U MT DTT DMIY79U MA Inhibitor DMIY79U RN In silico identification and biochemical evaluation of novel inhibitors of NRH:quinone oxidoreductase 2 (NQO2). Bioorg Med Chem Lett. 2010 Dec 15;20(24):7331-6. DMIY79U RU https://pubmed.ncbi.nlm.nih.gov/21074425 DM7BXHQ DI DM7BXHQ DM7BXHQ DN GNF-PF-3878 DM7BXHQ MI TTWG9A4 DM7BXHQ MN Adrenergic receptor alpha-2A (ADRA2A) DM7BXHQ MT DTT DM7BXHQ MA Inhibitor DM7BXHQ RN Structure-activity relationship of quinoline derivatives as potent and selective alpha(2C)-adrenoceptor antagonists. J Med Chem. 2006 Oct 19;49(21):6351-63. DM7BXHQ RU https://pubmed.ncbi.nlm.nih.gov/17034141 DM7BXHQ DI DM7BXHQ DM7BXHQ DN GNF-PF-3878 DM7BXHQ MI TTWM4TY DM7BXHQ MN Adrenergic receptor alpha-2B (ADRA2B) DM7BXHQ MT DTT DM7BXHQ MA Inhibitor DM7BXHQ RN Structure-activity relationship of quinoline derivatives as potent and selective alpha(2C)-adrenoceptor antagonists. J Med Chem. 2006 Oct 19;49(21):6351-63. DM7BXHQ RU https://pubmed.ncbi.nlm.nih.gov/17034141 DM7BXHQ DI DM7BXHQ DM7BXHQ DN GNF-PF-3878 DM7BXHQ MI TT2NUT5 DM7BXHQ MN Adrenergic receptor alpha-2C (ADRA2C) DM7BXHQ MT DTT DM7BXHQ MA Inhibitor DM7BXHQ RN Structure-activity relationship of quinoline derivatives as potent and selective alpha(2C)-adrenoceptor antagonists. J Med Chem. 2006 Oct 19;49(21):6351-63. DM7BXHQ RU https://pubmed.ncbi.nlm.nih.gov/17034141 DMOJL61 DI DMOJL61 DMOJL61 DN GNF-PF-3955 DMOJL61 MI TTL53M6 DMOJL61 MN Induced myeloid leukemia cell differentiation protein Mcl-1 (MCL1) DMOJL61 MT DTT DMOJL61 MA Inhibitor DMOJL61 RN In silico identification and biochemical evaluation of novel inhibitors of NRH:quinone oxidoreductase 2 (NQO2). Bioorg Med Chem Lett. 2010 Dec 15;20(24):7331-6. DMOJL61 RU https://pubmed.ncbi.nlm.nih.gov/21074425 DMXWYMH DI DMXWYMH DMXWYMH DN GNF-PF-4292 DMXWYMH MI TTVG215 DMXWYMH MN Debrisoquine 4-hydroxylase (CYP2D6) DMXWYMH MT DTT DMXWYMH MA Inhibitor DMXWYMH RN Development of a pharmacophore for inhibition of human liver cytochrome P-450 2D6: molecular modeling and inhibition studies. J Med Chem. 1993 Apr 30;36(9):1136-45. DMXWYMH RU https://pubmed.ncbi.nlm.nih.gov/8487254 DMV10UH DI DMV10UH DMV10UH DN GNF-PF-4421 DMV10UH MI TT1MPAY DMV10UH MN GABA(A) receptor alpha-1 (GABRA1) DMV10UH MT DTT DMV10UH MA Inhibitor DMV10UH RN 4-quinolone derivatives: high-affinity ligands at the benzodiazepine site of brain GABA A receptors. synthesis, pharmacology, and pharmacophore mod... J Med Chem. 2006 Apr 20;49(8):2526-33. DMV10UH RU https://pubmed.ncbi.nlm.nih.gov/16610795 DMV10UH DI DMV10UH DMV10UH DN GNF-PF-4421 DMV10UH MI TTZA1NY DMV10UH MN GABA(A) receptor beta-2 (GABRB2) DMV10UH MT DTT DMV10UH MA Inhibitor DMV10UH RN 4-quinolone derivatives: high-affinity ligands at the benzodiazepine site of brain GABA A receptors. synthesis, pharmacology, and pharmacophore mod... J Med Chem. 2006 Apr 20;49(8):2526-33. DMV10UH RU https://pubmed.ncbi.nlm.nih.gov/16610795 DMV10UH DI DMV10UH DMV10UH DN GNF-PF-4421 DMV10UH MI TT06RH5 DMV10UH MN GABA(A) receptor gamma-2 (GABRG2) DMV10UH MT DTT DMV10UH MA Inhibitor DMV10UH RN 4-quinolone derivatives: high-affinity ligands at the benzodiazepine site of brain GABA A receptors. synthesis, pharmacology, and pharmacophore mod... J Med Chem. 2006 Apr 20;49(8):2526-33. DMV10UH RU https://pubmed.ncbi.nlm.nih.gov/16610795 DMV10UH DI DMV10UH DMV10UH DN GNF-PF-4421 DMV10UH MI TTNJYV2 DMV10UH MN Gamma-aminobutyric acid receptor (GAR) DMV10UH MT DTT DMV10UH MA Inhibitor DMV10UH RN 4-quinolone derivatives: high-affinity ligands at the benzodiazepine site of brain GABA A receptors. synthesis, pharmacology, and pharmacophore mod... J Med Chem. 2006 Apr 20;49(8):2526-33. DMV10UH RU https://pubmed.ncbi.nlm.nih.gov/16610795 DMPYIA3 DI DMPYIA3 DMPYIA3 DN GNF-PF-4453 DMPYIA3 MI TTG5QB7 DMPYIA3 MN Calpain-2 (CAPN2) DMPYIA3 MT DTT DMPYIA3 MA Inhibitor DMPYIA3 RN In silico identification and biochemical evaluation of novel inhibitors of NRH:quinone oxidoreductase 2 (NQO2). Bioorg Med Chem Lett. 2010 Dec 15;20(24):7331-6. DMPYIA3 RU https://pubmed.ncbi.nlm.nih.gov/21074425 DMCDU8K DI DMCDU8K DMCDU8K DN GNF-PF-4478 DMCDU8K MI TT2EDHU DMCDU8K MN Insulin-degrading enzyme (IDE) DMCDU8K MT DTT DMCDU8K MA Inhibitor DMCDU8K RN In silico identification and biochemical evaluation of novel inhibitors of NRH:quinone oxidoreductase 2 (NQO2). Bioorg Med Chem Lett. 2010 Dec 15;20(24):7331-6. DMCDU8K RU https://pubmed.ncbi.nlm.nih.gov/21074425 DMCDU8K DI DMCDU8K DMCDU8K DN GNF-PF-4478 DMCDU8K MI TTEAID7 DMCDU8K MN Trypanosoma Cruzipain (Trypano CYSP) DMCDU8K MT DTT DMCDU8K MA Inhibitor DMCDU8K RN Complementarity between a docking and a high-throughput screen in discovering new cruzain inhibitors. J Med Chem. 2010 Jul 8;53(13):4891-905. DMCDU8K RU https://pubmed.ncbi.nlm.nih.gov/20540517 DM1ZMUN DI DM1ZMUN DM1ZMUN DN GNF-PF-4599 DM1ZMUN MI TTZPWGN DM1ZMUN MN Voltage-gated calcium channel alpha Cav3.2 (CACNA1H) DM1ZMUN MT DTT DM1ZMUN MA Inhibitor DM1ZMUN RN 3D pharmacophore based virtual screening of T-type calcium channel blockers. Bioorg Med Chem. 2007 Jan 15;15(2):1091-105. DM1ZMUN RU https://pubmed.ncbi.nlm.nih.gov/17074493 DM7850H DI DM7850H DM7850H DN GNF-PF-5134 DM7850H MI TT915ZD DM7850H MN Candida Mannose-6-phosphate isomerase (Candi PMI1) DM7850H MT DTT DM7850H MA Inhibitor DM7850H RN In silico identification and biochemical evaluation of novel inhibitors of NRH:quinone oxidoreductase 2 (NQO2). Bioorg Med Chem Lett. 2010 Dec 15;20(24):7331-6. DM7850H RU https://pubmed.ncbi.nlm.nih.gov/21074425 DM7850H DI DM7850H DM7850H DN GNF-PF-5134 DM7850H MI TTL53M6 DM7850H MN Induced myeloid leukemia cell differentiation protein Mcl-1 (MCL1) DM7850H MT DTT DM7850H MA Inhibitor DM7850H RN In silico identification and biochemical evaluation of novel inhibitors of NRH:quinone oxidoreductase 2 (NQO2). Bioorg Med Chem Lett. 2010 Dec 15;20(24):7331-6. DM7850H RU https://pubmed.ncbi.nlm.nih.gov/21074425 DMVI4JG DI DMVI4JG DMVI4JG DN GNF-PF-5188 DMVI4JG MI TTMSFAW DMVI4JG MN Cannabinoid receptor 2 (CB2) DMVI4JG MT DTT DMVI4JG MA Inhibitor DMVI4JG RN Discovery of novel CB2 receptor ligands by a pharmacophore-based virtual screening workflow. J Med Chem. 2009 Jan 22;52(2):369-78. DMVI4JG RU https://pubmed.ncbi.nlm.nih.gov/19143566 DMZNAEQ DI DMZNAEQ DMZNAEQ DN GNF-PF-5411 DMZNAEQ MI TTVG215 DMZNAEQ MN Debrisoquine 4-hydroxylase (CYP2D6) DMZNAEQ MT DTT DMZNAEQ MA Inhibitor DMZNAEQ RN Development of a pharmacophore for inhibition of human liver cytochrome P-450 2D6: molecular modeling and inhibition studies. J Med Chem. 1993 Apr 30;36(9):1136-45. DMZNAEQ RU https://pubmed.ncbi.nlm.nih.gov/8487254 DMZNAEQ DI DMZNAEQ DMZNAEQ DN GNF-PF-5411 DMZNAEQ MI DTUGYRD DMZNAEQ MN P-glycoprotein 1 (ABCB1) DMZNAEQ MT DTP DMZNAEQ MA Substrate DMZNAEQ RN Human intestinal transporter database: QSAR modeling and virtual profiling of drug uptake, efflux and interactions. Pharm Res. 2013 Apr;30(4):996-1007. DMZNAEQ RU https://doi.org/10.1007/s11095-012-0935-x DMP9AIH DI DMP9AIH DMP9AIH DN GNF-PF-5434 DMP9AIH MI TTF2LRI DMP9AIH MN Cathepsin B (CTSB) DMP9AIH MT DTT DMP9AIH MA Inhibitor DMP9AIH RN Substrate optimization for monitoring cathepsin C activity in live cells. Bioorg Med Chem. 2009 Feb 1;17(3):1064-70. DMP9AIH RU https://pubmed.ncbi.nlm.nih.gov/18313933 DMP9AIH DI DMP9AIH DMP9AIH DN GNF-PF-5434 DMP9AIH MI TTDZN01 DMP9AIH MN Cathepsin K (CTSK) DMP9AIH MT DTT DMP9AIH MA Inhibitor DMP9AIH RN Substrate optimization for monitoring cathepsin C activity in live cells. Bioorg Med Chem. 2009 Feb 1;17(3):1064-70. DMP9AIH RU https://pubmed.ncbi.nlm.nih.gov/18313933 DMP9AIH DI DMP9AIH DMP9AIH DN GNF-PF-5434 DMP9AIH MI TTUMQVO DMP9AIH MN Cathepsin S (CTSS) DMP9AIH MT DTT DMP9AIH MA Inhibitor DMP9AIH RN Substrate optimization for monitoring cathepsin C activity in live cells. Bioorg Med Chem. 2009 Feb 1;17(3):1064-70. DMP9AIH RU https://pubmed.ncbi.nlm.nih.gov/18313933 DMP9AIH DI DMP9AIH DMP9AIH DN GNF-PF-5434 DMP9AIH MI TT4H0V2 DMP9AIH MN Dipeptidyl peptidase I (CTSC) DMP9AIH MT DTT DMP9AIH MA Inhibitor DMP9AIH RN Substrate optimization for monitoring cathepsin C activity in live cells. Bioorg Med Chem. 2009 Feb 1;17(3):1064-70. DMP9AIH RU https://pubmed.ncbi.nlm.nih.gov/18313933 DMT8VUS DI DMT8VUS DMT8VUS DN GNF-PF-5618 DMT8VUS MI TTZ9SOR DMT8VUS MN Muscarinic acetylcholine receptor M1 (CHRM1) DMT8VUS MT DTT DMT8VUS MA Inhibitor DMT8VUS RN Nocardimicins A, B, C, D, E, and F, siderophores with muscarinic M3 receptor inhibiting activity from Nocardia sp. TP-A0674. J Nat Prod. 2005 Jul;68(7):1061-5. DMT8VUS RU https://pubmed.ncbi.nlm.nih.gov/16038549 DMT8VUS DI DMT8VUS DMT8VUS DN GNF-PF-5618 DMT8VUS MI TTYEG6Q DMT8VUS MN Muscarinic acetylcholine receptor M2 (CHRM2) DMT8VUS MT DTT DMT8VUS MA Inhibitor DMT8VUS RN Nocardimicins A, B, C, D, E, and F, siderophores with muscarinic M3 receptor inhibiting activity from Nocardia sp. TP-A0674. J Nat Prod. 2005 Jul;68(7):1061-5. DMT8VUS RU https://pubmed.ncbi.nlm.nih.gov/16038549 DMT8VUS DI DMT8VUS DMT8VUS DN GNF-PF-5618 DMT8VUS MI TTQ13Z5 DMT8VUS MN Muscarinic acetylcholine receptor M3 (CHRM3) DMT8VUS MT DTT DMT8VUS MA Inhibitor DMT8VUS RN Nocardimicins A, B, C, D, E, and F, siderophores with muscarinic M3 receptor inhibiting activity from Nocardia sp. TP-A0674. J Nat Prod. 2005 Jul;68(7):1061-5. DMT8VUS RU https://pubmed.ncbi.nlm.nih.gov/16038549 DMT8VUS DI DMT8VUS DMT8VUS DN GNF-PF-5618 DMT8VUS MI TTQ3JTF DMT8VUS MN Muscarinic acetylcholine receptor M4 (CHRM4) DMT8VUS MT DTT DMT8VUS MA Inhibitor DMT8VUS RN Nocardimicins A, B, C, D, E, and F, siderophores with muscarinic M3 receptor inhibiting activity from Nocardia sp. TP-A0674. J Nat Prod. 2005 Jul;68(7):1061-5. DMT8VUS RU https://pubmed.ncbi.nlm.nih.gov/16038549 DMT8VUS DI DMT8VUS DMT8VUS DN GNF-PF-5618 DMT8VUS MI TTH18TF DMT8VUS MN Muscarinic acetylcholine receptor M5 (CHRM5) DMT8VUS MT DTT DMT8VUS MA Inhibitor DMT8VUS RN Nocardimicins A, B, C, D, E, and F, siderophores with muscarinic M3 receptor inhibiting activity from Nocardia sp. TP-A0674. J Nat Prod. 2005 Jul;68(7):1061-5. DMT8VUS RU https://pubmed.ncbi.nlm.nih.gov/16038549 DMWGXBF DI DMWGXBF DMWGXBF DN GNF-PF-600 DMWGXBF MI TTIQSC1 DMWGXBF MN Bacterial Lethal factor (Bact lef) DMWGXBF MT DTT DMWGXBF MA Inhibitor DMWGXBF RN Anthrax lethal factor protease inhibitors: synthesis, SAR, and structure-based 3D QSAR studies. J Med Chem. 2006 Jan 12;49(1):27-30. DMWGXBF RU https://pubmed.ncbi.nlm.nih.gov/16392787 DMJXE6K DI DMJXE6K DMJXE6K DN GNF-PF-607 DMJXE6K MI TT9SL3Q DMJXE6K MN Polypeptide deformylase (PDF) DMJXE6K MT DTT DMJXE6K MA Inhibitor DMJXE6K RN CoMFA and CoMSIA analyses of Pneumocystis carinii dihydrofolate reductase, Toxoplasma gondii dihydrofolate reductase, and rat liver dihydrofolate r... J Med Chem. 2005 Mar 10;48(5):1448-69. DMJXE6K RU https://pubmed.ncbi.nlm.nih.gov/15743188 DM3SYH5 DI DM3SYH5 DM3SYH5 DN GNF-PF-67 DM3SYH5 MI TT78R5H DM3SYH5 MN Heat shock protein 90 alpha (HSP90A) DM3SYH5 MT DTT DM3SYH5 MA Inhibitor DM3SYH5 RN In silico identification and biochemical evaluation of novel inhibitors of NRH:quinone oxidoreductase 2 (NQO2). Bioorg Med Chem Lett. 2010 Dec 15;20(24):7331-6. DM3SYH5 RU https://pubmed.ncbi.nlm.nih.gov/21074425 DM7SPRJ DI DM7SPRJ DM7SPRJ DN GNF-PF-78 DM7SPRJ MI TT124R0 DM7SPRJ MN Nuclear receptor coactivator 3 (NCOA3) DM7SPRJ MT DTT DM7SPRJ MA Inhibitor DM7SPRJ RN In silico identification and biochemical evaluation of novel inhibitors of NRH:quinone oxidoreductase 2 (NQO2). Bioorg Med Chem Lett. 2010 Dec 15;20(24):7331-6. DM7SPRJ RU https://pubmed.ncbi.nlm.nih.gov/21074425 DM7SPRJ DI DM7SPRJ DM7SPRJ DN GNF-PF-78 DM7SPRJ MI TT9JZCK DM7SPRJ MN Sphingosine-1-phosphate receptor 1 (S1PR1) DM7SPRJ MT DTT DM7SPRJ MA Inhibitor DM7SPRJ RN In silico identification and biochemical evaluation of novel inhibitors of NRH:quinone oxidoreductase 2 (NQO2). Bioorg Med Chem Lett. 2010 Dec 15;20(24):7331-6. DM7SPRJ RU https://pubmed.ncbi.nlm.nih.gov/21074425 DM37ORC DI DM37ORC DM37ORC DN GNF-PF-826 DM37ORC MI TT124R0 DM37ORC MN Nuclear receptor coactivator 3 (NCOA3) DM37ORC MT DTT DM37ORC MA Inhibitor DM37ORC RN In silico identification and biochemical evaluation of novel inhibitors of NRH:quinone oxidoreductase 2 (NQO2). Bioorg Med Chem Lett. 2010 Dec 15;20(24):7331-6. DM37ORC RU https://pubmed.ncbi.nlm.nih.gov/21074425 DM37ORC DI DM37ORC DM37ORC DN GNF-PF-826 DM37ORC MI TT9JZCK DM37ORC MN Sphingosine-1-phosphate receptor 1 (S1PR1) DM37ORC MT DTT DM37ORC MA Inhibitor DM37ORC RN In silico identification and biochemical evaluation of novel inhibitors of NRH:quinone oxidoreductase 2 (NQO2). Bioorg Med Chem Lett. 2010 Dec 15;20(24):7331-6. DM37ORC RU https://pubmed.ncbi.nlm.nih.gov/21074425 DMB6FN7 DI DMB6FN7 DMB6FN7 DN GNF-PF-85 DMB6FN7 MI TT3PQ2Y DMB6FN7 MN Plasmodium Dihydroorotate dehydrogenase (Malaria DHOdehase) DMB6FN7 MT DTT DMB6FN7 MA Inhibitor DMB6FN7 RN Triazolopyrimidine-based dihydroorotate dehydrogenase inhibitors with potent and selective activity against the malaria parasite Plasmodium falcipa... J Med Chem. 2008 Jun 26;51(12):3649-53. DMB6FN7 RU https://pubmed.ncbi.nlm.nih.gov/18522386 DMKVTZN DI DMKVTZN DMKVTZN DN Go 6983 DMKVTZN MI TT7A1BO DMKVTZN MN PKC-delta messenger RNA (PRKCD mRNA) DMKVTZN MT DTT DMKVTZN MA Inhibitor DMKVTZN RN Inhibition of protein kinase C mu by various inhibitors. Differentiation from protein kinase c isoenzymes. FEBS Lett. 1996 Aug 26;392(2):77-80. DMKVTZN RU https://pubmed.ncbi.nlm.nih.gov/8772178 DMKVTZN DI DMKVTZN DMKVTZN DN Go 6983 DMKVTZN MI TTBSN0L DMKVTZN MN PKC-zeta messenger RNA (PRKCZ mRNA) DMKVTZN MT DTT DMKVTZN MA Inhibitor DMKVTZN RN Inhibition of protein kinase C mu by various inhibitors. Differentiation from protein kinase c isoenzymes. FEBS Lett. 1996 Aug 26;392(2):77-80. DMKVTZN RU https://pubmed.ncbi.nlm.nih.gov/8772178 DMKVTZN DI DMKVTZN DMKVTZN DN Go 6983 DMKVTZN MI TTFJ8Q1 DMKVTZN MN Protein kinase C alpha (PRKCA) DMKVTZN MT DTT DMKVTZN MA Inhibitor DMKVTZN RN Inhibition of protein kinase C mu by various inhibitors. Differentiation from protein kinase c isoenzymes. FEBS Lett. 1996 Aug 26;392(2):77-80. DMKVTZN RU https://pubmed.ncbi.nlm.nih.gov/8772178 DMKVTZN DI DMKVTZN DMKVTZN DN Go 6983 DMKVTZN MI TTYPXQF DMKVTZN MN Protein kinase C beta (PRKCB) DMKVTZN MT DTT DMKVTZN MA Inhibitor DMKVTZN RN Inhibition of protein kinase C mu by various inhibitors. Differentiation from protein kinase c isoenzymes. FEBS Lett. 1996 Aug 26;392(2):77-80. DMKVTZN RU https://pubmed.ncbi.nlm.nih.gov/8772178 DMKVTZN DI DMKVTZN DMKVTZN DN Go 6983 DMKVTZN MI TTRFOXJ DMKVTZN MN Protein kinase C gamma (PRKCG) DMKVTZN MT DTT DMKVTZN MA Inhibitor DMKVTZN RN Inhibition of protein kinase C mu by various inhibitors. Differentiation from protein kinase c isoenzymes. FEBS Lett. 1996 Aug 26;392(2):77-80. DMKVTZN RU https://pubmed.ncbi.nlm.nih.gov/8772178 DMS91OR DI DMS91OR DMS91OR DN Go7874 DMS91OR MI TTOXS3C DMS91OR MN Muscarinic acetylcholine receptor (CHRM) DMS91OR MT DTT DMS91OR MA Modulator (allosteric modulator) DMS91OR RN Allosteric interactions of staurosporine and other indolocarbazoles with N-[methyl-(3)H]scopolamine and acetylcholine at muscarinic receptor subtypes: identification of a second allosteric site. Mol Pharmacol. 2000 Jul;58(1):194-207. DMS91OR RU https://pubmed.ncbi.nlm.nih.gov/10860942 DMS91OR DI DMS91OR DMS91OR DN Go7874 DMS91OR MI TTQ13Z5 DMS91OR MN Muscarinic acetylcholine receptor M3 (CHRM3) DMS91OR MT DTT DMS91OR MA Modulator (allosteric modulator) DMS91OR RN Allosteric interactions of staurosporine and other indolocarbazoles with N-[methyl-(3)H]scopolamine and acetylcholine at muscarinic receptor subtypes: identification of a second allosteric site. Mol Pharmacol. 2000 Jul;58(1):194-207. DMS91OR RU https://pubmed.ncbi.nlm.nih.gov/10860942 DMS97A1 DI DMS97A1 DMS97A1 DN Gold trichloride sodium chloride DMS97A1 MI TTF2LRI DMS97A1 MN Cathepsin B (CTSB) DMS97A1 MT DTT DMS97A1 MA Inhibitor DMS97A1 RN Inhibition of lysosomal cysteine proteases by chrysotherapeutic compounds: a possible mechanism for the antiarthritic activity of Au(I). Bioorg Med Chem Lett. 2004 Oct 18;14(20):5113-6. DMS97A1 RU https://pubmed.ncbi.nlm.nih.gov/15380210 DMMT05U DI DMMT05U DMMT05U DN GOSSYPETIN DMMT05U MI TTSZLWK DMMT05U MN Aromatase (CYP19A1) DMMT05U MT DTT DMMT05U MA Inhibitor DMMT05U RN Screening of herbal constituents for aromatase inhibitory activity. Bioorg Med Chem. 2008 Sep 15;16(18):8466-70. DMMT05U RU https://pubmed.ncbi.nlm.nih.gov/18778944 DMMT05U DI DMMT05U DMMT05U DN GOSSYPETIN DMMT05U MI TT50QJ3 DMMT05U MN Influenza Neuraminidase (Influ NA) DMMT05U MT DTT DMMT05U MA Inhibitor DMMT05U RN Neuraminidase inhibitory activities of flavonols isolated from Rhodiola rosea roots and their in vitro anti-influenza viral activities. Bioorg Med Chem. 2009 Oct 1;17(19):6816-23. DMMT05U RU https://pubmed.ncbi.nlm.nih.gov/19729316 DMZNUAD DI DMZNUAD DMZNUAD DN Go-Y022 DMZNUAD MI TTVG215 DMZNUAD MN Debrisoquine 4-hydroxylase (CYP2D6) DMZNUAD MT DTT DMZNUAD MA Inhibitor DMZNUAD RN Structure-activity relationships for the inhibition of recombinant human cytochromes P450 by curcumin analogues. Eur J Med Chem. 2008 Aug;43(8):1621-31. DMZNUAD RU https://pubmed.ncbi.nlm.nih.gov/18249473 DMUNSLJ DI DMUNSLJ DMUNSLJ DN Go-Y026 DMUNSLJ MI TTXV4FI DMUNSLJ MN Albendazole monooxygenase (CYP3A4) DMUNSLJ MT DTT DMUNSLJ MA Inhibitor DMUNSLJ RN Structure-activity relationships for the inhibition of recombinant human cytochromes P450 by curcumin analogues. Eur J Med Chem. 2008 Aug;43(8):1621-31. DMUNSLJ RU https://pubmed.ncbi.nlm.nih.gov/18249473 DMRUIX3 DI DMRUIX3 DMRUIX3 DN GP515 DMRUIX3 MI TTL732K DMRUIX3 MN Adenosine kinase (ADK) DMRUIX3 MT DTT DMRUIX3 MA Inhibitor DMRUIX3 RN Adenosine kinase inhibitor GP515 improves experimental colitis in mice. J Pharmacol Exp Ther. 2001 Jan;296(1):99-105. DMRUIX3 RU https://pubmed.ncbi.nlm.nih.gov/11123368 DMRUIX3 DI DMRUIX3 DMRUIX3 DN GP515 DMRUIX3 MI TTTU72V DMRUIX3 MN Steroid 5-alpha-reductase 1 (SRD5A1) DMRUIX3 MT DTT DMRUIX3 MA Inhibitor DMRUIX3 RN 19-nor-10-azasteroids: a novel class of inhibitors for human steroid 5alpha-reductases 1 and 2. J Med Chem. 1997 Mar 28;40(7):1112-29. DMRUIX3 RU https://pubmed.ncbi.nlm.nih.gov/9089333 DMRUIX3 DI DMRUIX3 DMRUIX3 DN GP515 DMRUIX3 MI TTT02K8 DMRUIX3 MN Steroid 5-alpha-reductase 2 (SRD5A2) DMRUIX3 MT DTT DMRUIX3 MA Inhibitor DMRUIX3 RN 19-nor-10-azasteroids: a novel class of inhibitors for human steroid 5alpha-reductases 1 and 2. J Med Chem. 1997 Mar 28;40(7):1112-29. DMRUIX3 RU https://pubmed.ncbi.nlm.nih.gov/9089333 DM1W5G9 DI DM1W5G9 DM1W5G9 DN GPCR39 pepducins DM1W5G9 MI TTTPCNU DM1W5G9 MN G-protein coupled receptor 39 (GPR39) DM1W5G9 MT DTT DM1W5G9 MA Modulator DM1W5G9 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 105). DM1W5G9 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=105 DMRJ5OD DI DMRJ5OD DMRJ5OD DN GPG-290 DMRJ5OD MI TT1290U DMRJ5OD MN Coagulation factor VIII (F8) DMRJ5OD MT DTT DMRJ5OD MA Inhibitor DMRJ5OD RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2607). DMRJ5OD RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2607 DMAY48N DI DMAY48N DMAY48N DN GPI 18214 DMAY48N MI TT39J16 DMAY48N MN Poly [ADP-ribose] glycohydrolase (PARG) DMAY48N MT DTT DMAY48N MA Inhibitor DMAY48N RN Treatment with a novel poly(ADP-ribose) glycohydrolase inhibitor reduces development of septic shock-like syndrome induced by zymosan in mice. Crit Care Med. 2004 Jun;32(6):1365-74. DMAY48N RU https://pubmed.ncbi.nlm.nih.gov/15187521 DMLRTPH DI DMLRTPH DMLRTPH DN GPYRMEHFRWGSPPKD-NH2 DMLRTPH MI TTEOSZT DMLRTPH MN Melanocortin receptor (MCR) DMLRTPH MT DTT DMLRTPH MA Inhibitor DMLRTPH RN Discovery of a beta-MSH-derived MC-4R selective agonist. J Med Chem. 2005 May 5;48(9):3095-8. DMLRTPH RU https://pubmed.ncbi.nlm.nih.gov/15857110 DMLRTPH DI DMLRTPH DMLRTPH DN GPYRMEHFRWGSPPKD-NH2 DMLRTPH MI TT0MV2T DMLRTPH MN Melanocortin receptor 1 (MC1R) DMLRTPH MT DTT DMLRTPH MA Inhibitor DMLRTPH RN Discovery of a beta-MSH-derived MC-4R selective agonist. J Med Chem. 2005 May 5;48(9):3095-8. DMLRTPH RU https://pubmed.ncbi.nlm.nih.gov/15857110 DMLRTPH DI DMLRTPH DMLRTPH DN GPYRMEHFRWGSPPKD-NH2 DMLRTPH MI TTNI91K DMLRTPH MN Melanocortin receptor 3 (MC3R) DMLRTPH MT DTT DMLRTPH MA Inhibitor DMLRTPH RN Discovery of a beta-MSH-derived MC-4R selective agonist. J Med Chem. 2005 May 5;48(9):3095-8. DMLRTPH RU https://pubmed.ncbi.nlm.nih.gov/15857110 DMLRTPH DI DMLRTPH DMLRTPH DN GPYRMEHFRWGSPPKD-NH2 DMLRTPH MI TTD0CIQ DMLRTPH MN Melanocortin receptor 4 (MC4R) DMLRTPH MT DTT DMLRTPH MA Inhibitor DMLRTPH RN Discovery of a beta-MSH-derived MC-4R selective agonist. J Med Chem. 2005 May 5;48(9):3095-8. DMLRTPH RU https://pubmed.ncbi.nlm.nih.gov/15857110 DMMX7KL DI DMMX7KL DMMX7KL DN GR 125,743 DMMX7KL MI TTSQIFT DMMX7KL MN 5-HT 1A receptor (HTR1A) DMMX7KL MT DTT DMMX7KL MA Antagonist DMMX7KL RN Agonist activity of antimigraine drugs at recombinant human 5-HT1A receptors: potential implications for prophylactic and acute therapy. Naunyn Schmiedebergs Arch Pharmacol. 1997 Jun;355(6):682-8. DMMX7KL RU https://pubmed.ncbi.nlm.nih.gov/9205951 DM72B86 DI DM72B86 DM72B86 DN GR 125487 DM72B86 MI TT07C3Y DM72B86 MN 5-HT 4 receptor (HTR4) DM72B86 MT DTT DM72B86 MA Antagonist DM72B86 RN Cloning, expression and pharmacology of the mouse 5-HT(4L) receptor. FEBS Lett. 1996 Nov 25;398(1):19-25. DM72B86 RU https://pubmed.ncbi.nlm.nih.gov/8946946 DMAI9Y0 DI DMAI9Y0 DMAI9Y0 DN GR 128107 DMAI9Y0 MI TT0WAIE DMAI9Y0 MN Melatonin receptor type 1A (MTNR1A) DMAI9Y0 MT DTT DMAI9Y0 MA Agonist DMAI9Y0 RN The putative melatonin receptor antagonist GR128107 is a partial agonist on Xenopus laevis melanophores. Br J Pharmacol. 1999 Mar;126(5):1237-45. DMAI9Y0 RU https://pubmed.ncbi.nlm.nih.gov/10205014 DMHAWYJ DI DMHAWYJ DMHAWYJ DN GR 196429 DMHAWYJ MI TT0WAIE DMHAWYJ MN Melatonin receptor type 1A (MTNR1A) DMHAWYJ MT DTT DMHAWYJ MA Agonist DMHAWYJ RN GR196429: a nonindolic agonist at high-affinity melatonin receptors. J Pharmacol Exp Ther. 1998 Jun;285(3):1239-45. DMHAWYJ RU https://pubmed.ncbi.nlm.nih.gov/9618428 DMP1DO4 DI DMP1DO4 DMP1DO4 DN GR100679 DMP1DO4 MI TTYO0A3 DMP1DO4 MN Substance-K receptor (TACR2) DMP1DO4 MT DTT DMP1DO4 MA Antagonist DMP1DO4 RN Characterisation, CNS distribution and function of NK2 receptors studied using potent NK2 receptor antagonists. Regul Pept. 1993 Jul 2;46(1-2):9-19. DMP1DO4 RU https://pubmed.ncbi.nlm.nih.gov/8210508 DMFU9VH DI DMFU9VH DMFU9VH DN GR-113808 DMFU9VH MI TT07C3Y DMFU9VH MN 5-HT 4 receptor (HTR4) DMFU9VH MT DTT DMFU9VH MA Inhibitor DMFU9VH RN Synthesis of specific bivalent probes that functionally interact with 5-HT(4) receptor dimers. J Med Chem. 2007 Sep 6;50(18):4482-92. DMFU9VH RU https://pubmed.ncbi.nlm.nih.gov/17676726 DMQH8PK DI DMQH8PK DMQH8PK DN GR-133686 DMQH8PK MI TT2WR1T DMQH8PK MN Cationic trypsinogen (PRSS1) DMQH8PK MT DTT DMQH8PK MA Inhibitor DMQH8PK RN 5,5-trans lactone-containing inhibitors of serine proteases: identification of a novel, acylating thrombin inhibitor. Bioorg Med Chem Lett. 1998 Nov 3;8(21):2955-60. DMQH8PK RU https://pubmed.ncbi.nlm.nih.gov/9873654 DMQH8PK DI DMQH8PK DMQH8PK DN GR-133686 DMQH8PK MI TT6L509 DMQH8PK MN Coagulation factor IIa (F2) DMQH8PK MT DTT DMQH8PK MA Inhibitor DMQH8PK RN 5,5-trans lactone-containing inhibitors of serine proteases: identification of a novel, acylating thrombin inhibitor. Bioorg Med Chem Lett. 1998 Nov 3;8(21):2955-60. DMQH8PK RU https://pubmed.ncbi.nlm.nih.gov/9873654 DMW8YDR DI DMW8YDR DMW8YDR DN GR138676 DMW8YDR MI TTBPGLU DMW8YDR MN Neuromedin-K receptor (TACR3) DMW8YDR MT DTT DMW8YDR MA Antagonist DMW8YDR RN GR138676, a novel peptidic tachykinin antagonist which is potent at NK3 receptors. Neuropeptides. 1994 Dec;27(6):333-41. DMW8YDR RU https://pubmed.ncbi.nlm.nih.gov/7534879 DMIY9UF DI DMIY9UF DMIY9UF DN GR-38414 DMIY9UF MI TTQW87Y DMIY9UF MN Opioid receptor kappa (OPRK1) DMIY9UF MT DTT DMIY9UF MA Modulator DMIY9UF RN A series of novel, highly potent and selective agonists for the kappa-opioid receptor. Br J Pharmacol. 1990 Dec;101(4):944-8. DMIY9UF RU https://www.ncbi.nlm.nih.gov/pubmed/1964823 DM5UOYM DI DM5UOYM DM5UOYM DN GR-45809 DM5UOYM MI TTQW87Y DM5UOYM MN Opioid receptor kappa (OPRK1) DM5UOYM MT DTT DM5UOYM MA Modulator DM5UOYM RN J. Med. Chem. 1993,36, 2075-2083 DM5UOYM RU http://pubs.acs.org/doi/pdf/10.1021/jm00067a004 DM8L1Z2 DI DM8L1Z2 DM8L1Z2 DN GR55562 DM8L1Z2 MI TTK8CXU DM8L1Z2 MN 5-HT 1B receptor (HTR1B) DM8L1Z2 MT DTT DM8L1Z2 MA Antagonist DM8L1Z2 RN 5-hydroxytryptamine receptors mediating contraction in human small muscular pulmonary arteries: importance of the 5-HT1B receptor. Br J Pharmacol. 1999 Oct;128(3):730-4. DM8L1Z2 RU https://pubmed.ncbi.nlm.nih.gov/10516655 DMEO7CP DI DMEO7CP DMEO7CP DN GR-86014 DMEO7CP MI TTQW87Y DMEO7CP MN Opioid receptor kappa (OPRK1) DMEO7CP MT DTT DMEO7CP MA Modulator DMEO7CP RN Neuroprotective actions of GR89696, a highly potent and selective kappa-opioid receptor agonist. DMEO7CP RU https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1907793 DM9WY1D DI DM9WY1D DM9WY1D DN GR-91272 DM9WY1D MI TTQW87Y DM9WY1D MN Opioid receptor kappa (OPRK1) DM9WY1D MT DTT DM9WY1D MA Modulator DM9WY1D RN Neuroprotective actions of GR89696, a highly potent and selective kappa-opioid receptor agonist. DM9WY1D RU https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1907793 DMBYK0X DI DMBYK0X DMBYK0X DN GR94800 DMBYK0X MI TTYO0A3 DMBYK0X MN Substance-K receptor (TACR2) DMBYK0X MT DTT DMBYK0X MA Antagonist DMBYK0X RN Synthesis and characterization of selective fluorescent ligands for the neurokinin NK2 receptor. J Med Chem. 1994 Jun 24;37(13):1991-5. DMBYK0X RU https://pubmed.ncbi.nlm.nih.gov/8027981 DMVLQUP DI DMVLQUP DMVLQUP DN Grandisine C DMVLQUP MI TT27RFC DMVLQUP MN Opioid receptor delta (OPRD1) DMVLQUP MT DTT DMVLQUP MA Inhibitor DMVLQUP RN Grandisines C-G, indolizidine alkaloids from the Australian rainforest tree Elaeocarpus grandis. J Nat Prod. 2006 Sep;69(9):1295-9. DMVLQUP RU https://pubmed.ncbi.nlm.nih.gov/16989522 DM0JHYF DI DM0JHYF DM0JHYF DN Grandisine D DM0JHYF MI TT27RFC DM0JHYF MN Opioid receptor delta (OPRD1) DM0JHYF MT DTT DM0JHYF MA Inhibitor DM0JHYF RN Grandisines C-G, indolizidine alkaloids from the Australian rainforest tree Elaeocarpus grandis. J Nat Prod. 2006 Sep;69(9):1295-9. DM0JHYF RU https://pubmed.ncbi.nlm.nih.gov/16989522 DM04S2P DI DM04S2P DM04S2P DN Grandisine F DM04S2P MI TT27RFC DM04S2P MN Opioid receptor delta (OPRD1) DM04S2P MT DTT DM04S2P MA Inhibitor DM04S2P RN Grandisines C-G, indolizidine alkaloids from the Australian rainforest tree Elaeocarpus grandis. J Nat Prod. 2006 Sep;69(9):1295-9. DM04S2P RU https://pubmed.ncbi.nlm.nih.gov/16989522 DM65SQK DI DM65SQK DM65SQK DN GRANULATIMIDE DM65SQK MI TTTU902 DM65SQK MN Checkpoint kinase-1 (CHK1) DM65SQK MT DTT DM65SQK MA Inhibitor DM65SQK RN Synthesis, in vitro antiproliferative activities, and Chk1 inhibitory properties of pyrrolo[3,4-a]carbazole-1,3-diones, pyrrolo[3,4-c]carbazole-1,3... Eur J Med Chem. 2008 Feb;43(2):282-92. DM65SQK RU https://pubmed.ncbi.nlm.nih.gov/17502122 DM1PWX2 DI DM1PWX2 DM1PWX2 DN Grassystatin a DM1PWX2 MI TT6KIOT DM1PWX2 MN Caspase-11 (CASP11) DM1PWX2 MT DTT DM1PWX2 MA Inhibitor DM1PWX2 RN Grassystatins A-C from marine cyanobacteria, potent cathepsin E inhibitors that reduce antigen presentation. J Med Chem. 2009 Sep 24;52(18):5732-47. DM1PWX2 RU https://pubmed.ncbi.nlm.nih.gov/19715320 DM1PWX2 DI DM1PWX2 DM1PWX2 DN Grassystatin a DM1PWX2 MI TTPT2QI DM1PWX2 MN Cathepsin D (CTSD) DM1PWX2 MT DTT DM1PWX2 MA Inhibitor DM1PWX2 RN Grassystatins A-C from marine cyanobacteria, potent cathepsin E inhibitors that reduce antigen presentation. J Med Chem. 2009 Sep 24;52(18):5732-47. DM1PWX2 RU https://pubmed.ncbi.nlm.nih.gov/19715320 DM1PWX2 DI DM1PWX2 DM1PWX2 DN Grassystatin a DM1PWX2 MI TT2WR1T DM1PWX2 MN Cationic trypsinogen (PRSS1) DM1PWX2 MT DTT DM1PWX2 MA Inhibitor DM1PWX2 RN Grassystatins A-C from marine cyanobacteria, potent cathepsin E inhibitors that reduce antigen presentation. J Med Chem. 2009 Sep 24;52(18):5732-47. DM1PWX2 RU https://pubmed.ncbi.nlm.nih.gov/19715320 DM1PWX2 DI DM1PWX2 DM1PWX2 DN Grassystatin a DM1PWX2 MI TT3NKIB DM1PWX2 MN Pancreatic elastase 1 (CELA1) DM1PWX2 MT DTT DM1PWX2 MA Inhibitor DM1PWX2 RN Grassystatins A-C from marine cyanobacteria, potent cathepsin E inhibitors that reduce antigen presentation. J Med Chem. 2009 Sep 24;52(18):5732-47. DM1PWX2 RU https://pubmed.ncbi.nlm.nih.gov/19715320 DM1PWX2 DI DM1PWX2 DM1PWX2 DN Grassystatin a DM1PWX2 MI TTP86E2 DM1PWX2 MN Plasminogen (PLG) DM1PWX2 MT DTT DM1PWX2 MA Inhibitor DM1PWX2 RN Grassystatins A-C from marine cyanobacteria, potent cathepsin E inhibitors that reduce antigen presentation. J Med Chem. 2009 Sep 24;52(18):5732-47. DM1PWX2 RU https://pubmed.ncbi.nlm.nih.gov/19715320 DM1PWX2 DI DM1PWX2 DM1PWX2 DN Grassystatin a DM1PWX2 MI TTM1TDX DM1PWX2 MN Tryptase alpha/beta-1 (Tryptase) DM1PWX2 MT DTT DM1PWX2 MA Inhibitor DM1PWX2 RN Grassystatins A-C from marine cyanobacteria, potent cathepsin E inhibitors that reduce antigen presentation. J Med Chem. 2009 Sep 24;52(18):5732-47. DM1PWX2 RU https://pubmed.ncbi.nlm.nih.gov/19715320 DMXSWF6 DI DMXSWF6 DMXSWF6 DN grayanotoxin III DMXSWF6 MI TT84DRB DMXSWF6 MN Voltage-gated sodium channel alpha Nav1.4 (SCN4A) DMXSWF6 MT DTT DMXSWF6 MA Activator DMXSWF6 RN Novel site on sodium channel alpha-subunit responsible for the differential sensitivity of grayanotoxin in skeletal and cardiac muscle. Mol Pharmacol. 2001 Oct;60(4):865-72. DMXSWF6 RU https://pubmed.ncbi.nlm.nih.gov/11562450 DMQHJTF DI DMQHJTF DMQHJTF DN Green tea DMQHJTF MI TTYEG6Q DMQHJTF MN Muscarinic acetylcholine receptor M2 (CHRM2) DMQHJTF MT DTT DMQHJTF MA Agonist DMQHJTF RN Evaluation of muscarinic agonist-induced analgesia in muscarinic acetylcholine receptor knockout mice. Mol Pharmacol. 2002 Nov;62(5):1084-93. DMQHJTF RU https://pubmed.ncbi.nlm.nih.gov/12391271 DMQHJTF DI DMQHJTF DMQHJTF DN Green tea DMQHJTF MI TTE14XG DMQHJTF MN Squalene monooxygenase (SQLE) DMQHJTF MT DTT DMQHJTF MA Inhibitor DMQHJTF RN Squalene epoxidase as hypocholesterolemic drug target revisited. Prog Lipid Res. 2003 Jan;42(1):37-50. DMQHJTF RU https://pubmed.ncbi.nlm.nih.gov/12467639 DM3A0TE DI DM3A0TE DM3A0TE DN GRI977143 DM3A0TE MI TTB7Y8I DM3A0TE MN Lysophosphatidic acid receptor 2 (LPAR2) DM3A0TE MT DTT DM3A0TE MA Agonist DM3A0TE RN Virtual screening for LPA2-specific agonists identifies a nonlipid compound with antiapoptotic actions. Mol Pharmacol. 2012 Dec;82(6):1162-73. DM3A0TE RU https://pubmed.ncbi.nlm.nih.gov/22968304 DMGTRZE DI DMGTRZE DMGTRZE DN grifolic acid DMGTRZE MI TT08JVB DMGTRZE MN G-protein coupled receptor 120 (GPR120) DMGTRZE MT DTT DMGTRZE MA Agonist DMGTRZE RN Novel selective ligands for free fatty acid receptors GPR120 and GPR40. Naunyn Schmiedebergs Arch Pharmacol. 2009 Sep;380(3):247-55. DMGTRZE RU https://pubmed.ncbi.nlm.nih.gov/19471906 DML09OS DI DML09OS DML09OS DN GRL-0667 DML09OS MI TTRGHB2 DML09OS MN SARS-CoV papain-like proteinase (PL-PRO) DML09OS MT DTT DML09OS MA Inhibitor DML09OS RN Severe acute respiratory syndrome coronavirus papain-like novel protease inhibitors: design, synthesis, protein-ligand X-ray structure and biologic... J Med Chem. 2010 Jul 8;53(13):4968-79. DML09OS RU https://pubmed.ncbi.nlm.nih.gov/20527968 DMR93MK DI DMR93MK DMR93MK DN GRL-7234 DMR93MK MI TT8JRS7 DMR93MK MN Beta-secretase (BACE) DMR93MK MT DTT DMR93MK MA Inhibitor DMR93MK RN Design, synthesis, and X-ray structure of potent memapsin 2 (beta-secretase) inhibitors with isophthalamide derivatives as the P2-P3-ligands. J Med Chem. 2007 May 17;50(10):2399-407. DMR93MK RU https://pubmed.ncbi.nlm.nih.gov/17432843 DMR93MK DI DMR93MK DMR93MK DN GRL-7234 DMR93MK MI TTPT2QI DMR93MK MN Cathepsin D (CTSD) DMR93MK MT DTT DMR93MK MA Inhibitor DMR93MK RN Design, synthesis, and X-ray structure of potent memapsin 2 (beta-secretase) inhibitors with isophthalamide derivatives as the P2-P3-ligands. J Med Chem. 2007 May 17;50(10):2399-407. DMR93MK RU https://pubmed.ncbi.nlm.nih.gov/17432843 DMJ47DM DI DMJ47DM DMJ47DM DN GRN-529 DMJ47DM MI TTHS256 DMJ47DM MN Metabotropic glutamate receptor 5 (mGluR5) DMJ47DM MT DTT DMJ47DM MA Modulator DMJ47DM RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 293). DMJ47DM RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=293 DMO6IM1 DI DMO6IM1 DMO6IM1 DN group E 1682-2106 DMO6IM1 MI TT5Y4EM DMO6IM1 MN N-formyl peptide receptor (FPR1) DMO6IM1 MT DTT DMO6IM1 MA Antagonist DMO6IM1 RN Integration of virtual screening with high-throughput flow cytometry to identify novel small molecule formylpeptide receptor antagonists. Mol Pharmacol. 2005 Nov;68(5):1301-10. DMO6IM1 RU https://pubmed.ncbi.nlm.nih.gov/16118363 DMG0OUD DI DMG0OUD DMG0OUD DN GS4071 DMG0OUD MI TT50QJ3 DMG0OUD MN Influenza Neuraminidase (Influ NA) DMG0OUD MT DTT DMG0OUD MA Inhibitor DMG0OUD RN Antiviral agents active against influenza A viruses. Nat Rev Drug Discov. 2006 Dec;5(12):1015-25. DMG0OUD RU https://pubmed.ncbi.nlm.nih.gov/17139286 DMEGY3Q DI DMEGY3Q DMEGY3Q DN GS-9256 + tegobuvir DMEGY3Q MI TTMVBWH DMEGY3Q MN Hepatitis C virus RNA-directed RNA polymerase (HCV NS5B) DMEGY3Q MT DTT DMEGY3Q MA Modulator DMEGY3Q RN The ChEMBL database in 2017. Nucleic Acids Res. 2017 Jan 4;45(D1):D945-D954. DMEGY3Q RU https://www.ncbi.nlm.nih.gov/pubmed/27899562 DMTKGA3 DI DMTKGA3 DMTKGA3 DN GSC-1 DMTKGA3 MI TTXWASR DMTKGA3 MN Intestinal maltase-glucoamylase (MGAM) DMTKGA3 MT DTT DMTKGA3 MA Inhibitor DMTKGA3 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2627). DMTKGA3 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2627 DMC2ZF6 DI DMC2ZF6 DMC2ZF6 DN GSK-008A DMC2ZF6 MI TTUV8G9 DMC2ZF6 MN Progesterone receptor (PGR) DMC2ZF6 MT DTT DMC2ZF6 MA Agonist DMC2ZF6 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 627). DMC2ZF6 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=627 DMNIVOX DI DMNIVOX DMNIVOX DN GSK-0660 DMNIVOX MI TT2JWF6 DMNIVOX MN Peroxisome proliferator-activated receptor delta (PPARD) DMNIVOX MT DTT DMNIVOX MA Inhibitor DMNIVOX RN Identification and characterization of 4-chloro-N-(2-{[5-trifluoromethyl)-2-pyridyl]sulfonyl}ethyl)benzamide (GSK3787), a selective and irreversibl... J Med Chem. 2010 Feb 25;53(4):1857-61. DMNIVOX RU https://pubmed.ncbi.nlm.nih.gov/20128594 DMDHZR1 DI DMDHZR1 DMDHZR1 DN GSK1016790A DMDHZR1 MI TTKP2SU DMDHZR1 MN Transient receptor potential cation channel V4 (TRPV4) DMDHZR1 MT DTT DMDHZR1 MA Activator DMDHZR1 RN N-((1S)-1-{[4-((2S)-2-{[(2,4-dichlorophenyl)sulfonyl]amino}-3-hydroxypropanoyl)-1-piperazinyl]carbonyl}-3-methylbutyl)-1-benzothiophene-2-carboxamide (GSK1016790A), a novel and potent transient receptor potential vanilloid 4 channel agonist induces urinary bladder contraction and hyperactivity: Part I. J Pharmacol Exp Ther. 2008 Aug;326(2):432-42. DMDHZR1 RU https://pubmed.ncbi.nlm.nih.gov/18499743 DMIWY7Q DI DMIWY7Q DMIWY7Q DN GSK1331268 DMIWY7Q MI TTXJ47W DMIWY7Q MN Metabotropic glutamate receptor 2 (mGluR2) DMIWY7Q MT DTT DMIWY7Q MA Modulator (allosteric modulator) DMIWY7Q RN The identification of structurally novel, selective, orally bioavailable positive modulators of mGluR2. Bioorg Med Chem Lett. 2010 Jan 15;20(2):759-62. DMIWY7Q RU https://pubmed.ncbi.nlm.nih.gov/20005096 DMHBUG5 DI DMHBUG5 DMHBUG5 DN GSK-1344386B DMHBUG5 MI TTFZYTO DMHBUG5 MN C-C chemokine receptor type 2 (CCR2) DMHBUG5 MT DTT DMHBUG5 MA Antagonist DMHBUG5 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 59). DMHBUG5 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=59 DMZUTXW DI DMZUTXW DMZUTXW DN GSK1511931 DMZUTXW MI TTQFBMY DMZUTXW MN IGF1R messenger RNA (IGF1R mRNA) DMZUTXW MT DTT DMZUTXW MA Inhibitor DMZUTXW RN Optimization of a series of 4,6-bis-anilino-1H-pyrrolo[2,3-d]pyrimidine inhibitors of IGF-1R: elimination of an acid-mediated decomposition pathway. Bioorg Med Chem Lett. 2009 Jan 15;19(2):373-7. DMZUTXW RU https://pubmed.ncbi.nlm.nih.gov/19081716 DMKN76P DI DMKN76P DMKN76P DN GSK-1564023A DMKN76P MI TTUV8G9 DMKN76P MN Progesterone receptor (PGR) DMKN76P MT DTT DMKN76P MA Inhibitor DMKN76P RN The identification a novel, selective, non-steroidal, functional glucocorticoid receptor antagonist. Bioorg Med Chem Lett. 2010 Apr 1;20(7):2340-3. DMKN76P RU https://pubmed.ncbi.nlm.nih.gov/20202837 DMG6TL7 DI DMG6TL7 DMG6TL7 DN GSK1614343 DMG6TL7 MI TTWDC17 DMG6TL7 MN Growth hormone secretagogue receptor 1 (GHSR) DMG6TL7 MT DTT DMG6TL7 MA Antagonist DMG6TL7 RN Discovery process and characterization of novel carbohydrazide derivatives as potent and selective GHSR1a antagonists. ChemMedChem. 2010 Sep 3;5(9):1450-5. DMG6TL7 RU https://pubmed.ncbi.nlm.nih.gov/20593439 DM9IZNP DI DM9IZNP DM9IZNP DN GSK-172981 DM9IZNP MI TTBPGLU DM9IZNP MN Neuromedin-K receptor (TACR3) DM9IZNP MT DTT DM9IZNP MA Antagonist DM9IZNP RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 362). DM9IZNP RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=362 DM4HLK3 DI DM4HLK3 DM4HLK3 DN GSK-1838705A DM4HLK3 MI TTPMQSO DM4HLK3 MN ALK tyrosine kinase receptor (ALK) DM4HLK3 MT DTT DM4HLK3 MA Inhibitor DM4HLK3 RN GSK1838705A inhibits the insulin-like growth factor-1 receptor and anaplastic lymphoma kinase and shows antitumor activity in experimental models of human cancers. Mol Cancer Ther. 2009 Oct;8(10):2811-20. DM4HLK3 RU https://pubmed.ncbi.nlm.nih.gov/19825801 DM4HLK3 DI DM4HLK3 DM4HLK3 DN GSK-1838705A DM4HLK3 MI TTQFBMY DM4HLK3 MN IGF1R messenger RNA (IGF1R mRNA) DM4HLK3 MT DTT DM4HLK3 MA Inhibitor DM4HLK3 RN Comprehensive analysis of kinase inhibitor selectivity. Nat Biotechnol. 2011 Oct 30;29(11):1046-51. DM4HLK3 RU https://pubmed.ncbi.nlm.nih.gov/22037378 DM4HLK3 DI DM4HLK3 DM4HLK3 DN GSK-1838705A DM4HLK3 MI TTCBFJO DM4HLK3 MN Insulin receptor (INSR) DM4HLK3 MT DTT DM4HLK3 MA Inhibitor DM4HLK3 RN GSK1838705A inhibits the insulin-like growth factor-1 receptor and anaplastic lymphoma kinase and shows antitumor activity in experimental models of human cancers. Mol Cancer Ther. 2009 Oct;8(10):2811-20. DM4HLK3 RU https://pubmed.ncbi.nlm.nih.gov/19825801 DM4HLK3 DI DM4HLK3 DM4HLK3 DN GSK-1838705A DM4HLK3 MI TTIXKA4 DM4HLK3 MN Ribosomal protein S6 kinase alpha-1 (RSK1) DM4HLK3 MT DTT DM4HLK3 MA Inhibitor DM4HLK3 RN GSK1838705A inhibits the insulin-like growth factor-1 receptor and anaplastic lymphoma kinase and shows antitumor activity in experimental models of human cancers. Mol Cancer Ther. 2009 Oct;8(10):2811-20. DM4HLK3 RU https://pubmed.ncbi.nlm.nih.gov/19825801 DM2KT17 DI DM2KT17 DM2KT17 DN GSK-1842799C DM2KT17 MI TT9JZCK DM2KT17 MN Sphingosine-1-phosphate receptor 1 (S1PR1) DM2KT17 MT DTT DM2KT17 MA Agonist DM2KT17 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 275). DM2KT17 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=275 DMMWBU6 DI DMMWBU6 DMMWBU6 DN GSK-188909 DMMWBU6 MI TT8JRS7 DMMWBU6 MN Beta-secretase (BACE) DMMWBU6 MT DTT DMMWBU6 MA Inhibitor DMMWBU6 RN Second generation of BACE-1 inhibitors. Part 1: The need for improved pharmacokinetics. Bioorg Med Chem Lett. 2009 Jul 1;19(13):3664-8. DMMWBU6 RU https://pubmed.ncbi.nlm.nih.gov/19428244 DMKXPOL DI DMKXPOL DMKXPOL DN GSK189254A DMKXPOL MI TT9JNIC DMKXPOL MN Histamine H3 receptor (H3R) DMKXPOL MT DTT DMKXPOL MA Antagonist DMKXPOL RN The histamine H3 receptor: from gene cloning to H3 receptor drugs. Nat Rev Drug Discov. 2005 Feb;4(2):107-20. DMKXPOL RU https://pubmed.ncbi.nlm.nih.gov/15665857 DM9GPAU DI DM9GPAU DM9GPAU DN GSK2033 DM9GPAU MI TTECBXN DM9GPAU MN Oxysterols receptor LXR-alpha (NR1H3) DM9GPAU MT DTT DM9GPAU MA Antagonist DM9GPAU RN Discovery of tertiary sulfonamides as potent liver X receptor antagonists. J Med Chem. 2010 Apr 22;53(8):3412-6. DM9GPAU RU https://pubmed.ncbi.nlm.nih.gov/20345102 DM9GPAU DI DM9GPAU DM9GPAU DN GSK2033 DM9GPAU MI TTXA6PH DM9GPAU MN Oxysterols receptor LXR-beta (NR1H2) DM9GPAU MT DTT DM9GPAU MA Antagonist DM9GPAU RN Discovery of tertiary sulfonamides as potent liver X receptor antagonists. J Med Chem. 2010 Apr 22;53(8):3412-6. DM9GPAU RU https://pubmed.ncbi.nlm.nih.gov/20345102 DMY2XV3 DI DMY2XV3 DMY2XV3 DN GSK2193874 DMY2XV3 MI TTKP2SU DMY2XV3 MN Transient receptor potential cation channel V4 (TRPV4) DMY2XV3 MT DTT DMY2XV3 MA Blocker (channel blocker) DMY2XV3 RN An orally active TRPV4 channel blocker prevents and resolves pulmonary edema induced by heart failure. Sci Transl Med. 2012 Nov 7;4(159):159ra148. DMY2XV3 RU https://pubmed.ncbi.nlm.nih.gov/23136043 DMZ2TD9 DI DMZ2TD9 DMZ2TD9 DN GSK2194069 DMZ2TD9 MI TT7AOUD DMZ2TD9 MN Fatty acid synthase (FASN) DMZ2TD9 MT DTT DMZ2TD9 MA Inhibitor DMZ2TD9 RN A human fatty acid synthase inhibitor binds beta-ketoacyl reductase in the keto-substrate site. Nat Chem Biol. 2014 Sep;10(9):774-9. DMZ2TD9 RU https://pubmed.ncbi.nlm.nih.gov/25086508 DM0DKQN DI DM0DKQN DM0DKQN DN GSK-2210875 DM0DKQN MI TTHS256 DM0DKQN MN Metabotropic glutamate receptor 5 (mGluR5) DM0DKQN MT DTT DM0DKQN MA Antagonist DM0DKQN RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 293). DM0DKQN RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=293 DM3BI7R DI DM3BI7R DM3BI7R DN GSK-2334470 DM3BI7R MI TT9QBI6 DM3BI7R MN Phosphoinositide dependent protein kinase-1 (PDPK1) DM3BI7R MT DTT DM3BI7R MA Inhibitor DM3BI7R RN Genetic inactivation or pharmacological inhibition of Pdk1 delays development and inhibits metastasis of Braf(V600E)::Pten(-/-) melanoma. Oncogene. 2014 Aug 21;33(34):4330-9. DM3BI7R RU https://pubmed.ncbi.nlm.nih.gov/24037523 DMLASOF DI DMLASOF DMLASOF DN GSK2606414 DMLASOF MI TTHLGB2 DMLASOF MN Myosin light chain kinase 2 (MYLK2) DMLASOF MT DTT DMLASOF MA Inhibitor DMLASOF RN Discovery of 7-methyl-5-(1-{[3-(trifluoromethyl)phenyl]acetyl}-2,3-dihydro-1H-indol-5-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine (GSK2606414), a potent and selective first-in-class inhibitor of protein kinase R (PKR)-like endoplasmic reticulum kinase (PERK). J Med Chem. 2012 Aug 23;55(16):7193-207. DMLASOF RU https://pubmed.ncbi.nlm.nih.gov/22827572 DMLASOF DI DMLASOF DMLASOF DN GSK2606414 DMLASOF MI TT5OU0D DMLASOF MN PRKR-like endoplasmic reticulum kinase (PERK) DMLASOF MT DTT DMLASOF MA Inhibitor DMLASOF RN Discovery of 7-methyl-5-(1-{[3-(trifluoromethyl)phenyl]acetyl}-2,3-dihydro-1H-indol-5-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine (GSK2606414), a potent and selective first-in-class inhibitor of protein kinase R (PKR)-like endoplasmic reticulum kinase (PERK). J Med Chem. 2012 Aug 23;55(16):7193-207. DMLASOF RU https://pubmed.ncbi.nlm.nih.gov/22827572 DM325YR DI DM325YR DM325YR DN GSK-280 DM325YR MI TTQBR95 DM325YR MN Stress-activated protein kinase 2a (p38 alpha) DM325YR MT DTT DM325YR MA Inhibitor DM325YR RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1499). DM325YR RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1499 DMDSK9N DI DMDSK9N DMDSK9N DN GSK2801 DMDSK9N MI TT2MV0R DMDSK9N MN Bromodomain adjacent to zinc finger 2A (BAZ2A) DMDSK9N MT DTT DMDSK9N MA Inhibitor DMDSK9N RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2721). DMDSK9N RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2721 DMDSK9N DI DMDSK9N DMDSK9N DN GSK2801 DMDSK9N MI TT6K8YG DMDSK9N MN Bromodomain adjacent to zinc finger 2B (BAZ2B) DMDSK9N MT DTT DMDSK9N MA Inhibitor DMDSK9N RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2722). DMDSK9N RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2722 DM1865H DI DM1865H DM1865H DN GSK-325971A DM1865H MI TTUV8G9 DM1865H MN Progesterone receptor (PGR) DM1865H MT DTT DM1865H MA Inhibitor DM1865H RN The identification a novel, selective, non-steroidal, functional glucocorticoid receptor antagonist. Bioorg Med Chem Lett. 2010 Apr 1;20(7):2340-3. DM1865H RU https://pubmed.ncbi.nlm.nih.gov/20202837 DM5EO3F DI DM5EO3F DM5EO3F DN GSK-334429 DM5EO3F MI TT9JNIC DM5EO3F MN Histamine H3 receptor (H3R) DM5EO3F MT DTT DM5EO3F MA Antagonist DM5EO3F RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 264). DM5EO3F RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=264 DM9QU5Y DI DM9QU5Y DM9QU5Y DN GSK343 DM9QU5Y MI TTNJA0C DM9QU5Y MN Enhancer of zeste homolog 1 (EZH1) DM9QU5Y MT DTT DM9QU5Y MA Inhibitor DM9QU5Y RN Identification of Potent, Selective, Cell-Active Inhibitors of the Histone Lysine Methyltransferase EZH2. ACS Med Chem Lett. 2012 Oct 19;3(12):1091-6. DM9QU5Y RU https://pubmed.ncbi.nlm.nih.gov/24900432 DM9QU5Y DI DM9QU5Y DM9QU5Y DN GSK343 DM9QU5Y MI TT9MZCQ DM9QU5Y MN Enhancer of zeste homolog 2 (EZH2) DM9QU5Y MT DTT DM9QU5Y MA Inhibitor DM9QU5Y RN Identification of Potent, Selective, Cell-Active Inhibitors of the Histone Lysine Methyltransferase EZH2. ACS Med Chem Lett. 2012 Oct 19;3(12):1091-6. DM9QU5Y RU https://pubmed.ncbi.nlm.nih.gov/24900432 DMKDLB7 DI DMKDLB7 DMKDLB7 DN GSK-3787 DMKDLB7 MI TT2JWF6 DMKDLB7 MN Peroxisome proliferator-activated receptor delta (PPARD) DMKDLB7 MT DTT DMKDLB7 MA Inhibitor DMKDLB7 RN Identification and characterization of 4-chloro-N-(2-{[5-trifluoromethyl)-2-pyridyl]sulfonyl}ethyl)benzamide (GSK3787), a selective and irreversibl... J Med Chem. 2010 Feb 25;53(4):1857-61. DMKDLB7 RU https://pubmed.ncbi.nlm.nih.gov/20128594 DMQR7TZ DI DMQR7TZ DMQR7TZ DN GSK-3beta inhibitor II DMQR7TZ MI TTRSMW9 DMQR7TZ MN Glycogen synthase kinase-3 beta (GSK-3B) DMQR7TZ MT DTT DMQR7TZ MA Inhibitor DMQR7TZ RN Scaffold hopping and optimization towards libraries of glycogen synthase kinase-3 inhibitors. Bioorg Med Chem Lett. 2002 Jun 3;12(11):1525-8. DMQR7TZ RU https://pubmed.ncbi.nlm.nih.gov/12031334 DM734QB DI DM734QB DM734QB DN GSK-3beta inhibitor XI DM734QB MI TTRSMW9 DM734QB MN Glycogen synthase kinase-3 beta (GSK-3B) DM734QB MT DTT DM734QB MA Inhibitor DM734QB RN Design, synthesis, and biological evaluation of novel 7-azaindolyl-heteroaryl-maleimides as potent and selective glycogen synthase kinase-3beta (GSK-3beta) inhibitors. Bioorg Med Chem. 2004 Jun 15;12(12):3167-85. DM734QB RU https://pubmed.ncbi.nlm.nih.gov/15158785 DMHUMP9 DI DMHUMP9 DMHUMP9 DN GSK4716 DMHUMP9 MI TT9ZRHB DMHUMP9 MN Estrogen-related receptor-gamma (ESRRG) DMHUMP9 MT DTT DMHUMP9 MA Agonist DMHUMP9 RN Identification and structure-activity relationship of phenolic acyl hydrazones as selective agonists for the estrogen-related orphan nuclear receptors ERRbeta and ERRgamma. J Med Chem. 2005 May 5;48(9):3107-9. DMHUMP9 RU https://pubmed.ncbi.nlm.nih.gov/15857113 DMMIWHV DI DMMIWHV DMMIWHV DN GSK494581A DMMIWHV MI TTNET8J DMMIWHV MN G-protein coupled receptor 55 (GPR55) DMMIWHV MT DTT DMMIWHV MA Agonist DMMIWHV RN Pharmacology of GPR55 in yeast and identification of GSK494581A as a mixed-activity glycine transporter subtype 1 inhibitor and GPR55 agonist. J Pharmacol Exp Ther. 2011 Apr;337(1):236-46. DMMIWHV RU https://pubmed.ncbi.nlm.nih.gov/21233197 DMNGEAY DI DMNGEAY DMNGEAY DN GSK-5182 DMNGEAY MI TTZAYWL DMNGEAY MN Estrogen receptor (ESR) DMNGEAY MT DTT DMNGEAY MA Inhibitor DMNGEAY RN Structure-guided synthesis of tamoxifen analogs with improved selectivity for the orphan ERRgamma. Bioorg Med Chem Lett. 2006 Feb 15;16(4):821-4. DMNGEAY RU https://pubmed.ncbi.nlm.nih.gov/16307879 DM1I0AN DI DM1I0AN DM1I0AN DN GSK575594A DM1I0AN MI TTNET8J DM1I0AN MN G-protein coupled receptor 55 (GPR55) DM1I0AN MT DTT DM1I0AN MA Agonist DM1I0AN RN Pharmacology of GPR55 in yeast and identification of GSK494581A as a mixed-activity glycine transporter subtype 1 inhibitor and GPR55 agonist. J Pharmacol Exp Ther. 2011 Apr;337(1):236-46. DM1I0AN RU https://pubmed.ncbi.nlm.nih.gov/21233197 DMJXHU8 DI DMJXHU8 DMJXHU8 DN GSK579289A DMJXHU8 MI TT3VZ24 DMJXHU8 MN NIMA-related kinase 2 (NEK2) DMJXHU8 MT DTT DMJXHU8 MA Inhibitor DMJXHU8 RN Design of potent thiophene inhibitors of polo-like kinase 1 with improved solubility and reduced protein binding. Bioorg Med Chem Lett. 2009 Mar 15;19(6):1694-7. DMJXHU8 RU https://pubmed.ncbi.nlm.nih.gov/19237286 DMJXHU8 DI DMJXHU8 DMJXHU8 DN GSK579289A DMJXHU8 MI TTIYVQP DMJXHU8 MN Polo-like kinase 1 (PLK1) DMJXHU8 MT DTT DMJXHU8 MA Inhibitor DMJXHU8 RN Design of potent thiophene inhibitors of polo-like kinase 1 with improved solubility and reduced protein binding. Bioorg Med Chem Lett. 2009 Mar 15;19(6):1694-7. DMJXHU8 RU https://pubmed.ncbi.nlm.nih.gov/19237286 DMNRP2L DI DMNRP2L DMNRP2L DN GSK-650394 DMNRP2L MI TTTV8EJ DMNRP2L MN Serine/threonine-protein kinase Sgk1 (SGK1) DMNRP2L MT DTT DMNRP2L MA Inhibitor DMNRP2L RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 8040). DMNRP2L RU http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=8040 DMGW42V DI DMGW42V DMGW42V DN GSK-8062 DMGW42V MI TTXV4FI DMGW42V MN Albendazole monooxygenase (CYP3A4) DMGW42V MT DTT DMGW42V MA Inhibitor DMGW42V RN Conformationally constrained farnesoid X receptor (FXR) agonists: Naphthoic acid-based analogs of GW 4064. Bioorg Med Chem Lett. 2008 Aug 1;18(15):4339-43. DMGW42V RU https://pubmed.ncbi.nlm.nih.gov/18621523 DMT98PA DI DMT98PA DMT98PA DN GSK-812397 DMT98PA MI TTBID49 DMT98PA MN C-X-C chemokine receptor type 4 (CXCR4) DMT98PA MT DTT DMT98PA MA Antagonist DMT98PA RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 71). DMT98PA RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=71 DMSOWPE DI DMSOWPE DMSOWPE DN GSK-894281 DMSOWPE MI TTWDC17 DMSOWPE MN Growth hormone secretagogue receptor 1 (GHSR) DMSOWPE MT DTT DMSOWPE MA Agonist DMSOWPE RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 246). DMSOWPE RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=246 DMIDQ8B DI DMIDQ8B DMIDQ8B DN GSK931145 DMIDQ8B MI TTHJTF7 DMIDQ8B MN Glycine transporter GlyT-1 (SLC6A9) DMIDQ8B MT DTT DMIDQ8B MA Inhibitor DMIDQ8B RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 935). DMIDQ8B RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=935 DMW9AN1 DI DMW9AN1 DMW9AN1 DN GSK-9578 DMW9AN1 MI TTJ584C DMW9AN1 MN Peroxisome proliferator-activated receptor alpha (PPARA) DMW9AN1 MT DTT DMW9AN1 MA Inhibitor DMW9AN1 RN Peroxisome proliferator-activated receptor alpha activators improve insulin sensitivity and reduce adiposity. J Biol Chem. 2000 Jun 2;275(22):16638-42. DMW9AN1 RU https://pubmed.ncbi.nlm.nih.gov/10828060 DMNOU59 DI DMNOU59 DMNOU59 DN GSK'963 DMNOU59 MI TTAIQSN DMNOU59 MN Receptor-interacting protein 1 (RIPK1) DMNOU59 MT DTT DMNOU59 MA Inhibitor DMNOU59 RN Characterization of GSK'963: a structurally distinct, potent and selective inhibitor of RIP1 kinase. Cell Death Discov. 2015 Jul 27;1:15009. DMNOU59 RU https://pubmed.ncbi.nlm.nih.gov/27551444 DM4WS3R DI DM4WS3R DM4WS3R DN GSK-9772 DM4WS3R MI TTECBXN DM4WS3R MN Oxysterols receptor LXR-alpha (NR1H3) DM4WS3R MT DTT DM4WS3R MA Inhibitor DM4WS3R RN Structure-guided design of N-phenyl tertiary amines as transrepression-selective liver X receptor modulators with anti-inflammatory activity. J Med Chem. 2008 Sep 25;51(18):5758-65. DM4WS3R RU https://pubmed.ncbi.nlm.nih.gov/18800767 DM4WS3R DI DM4WS3R DM4WS3R DN GSK-9772 DM4WS3R MI TTXA6PH DM4WS3R MN Oxysterols receptor LXR-beta (NR1H2) DM4WS3R MT DTT DM4WS3R MA Inhibitor DM4WS3R RN Structure-guided design of N-phenyl tertiary amines as transrepression-selective liver X receptor modulators with anti-inflammatory activity. J Med Chem. 2008 Sep 25;51(18):5758-65. DM4WS3R RU https://pubmed.ncbi.nlm.nih.gov/18800767 DMY3SEN DI DMY3SEN DMY3SEN DN GSK-J1 DMY3SEN MI TTDIJUQ DMY3SEN MN Lysine-specific demethylase 6B (KDM6B) DMY3SEN MT DTT DMY3SEN MA Inhibitor DMY3SEN RN A selective jumonji H3K27 demethylase inhibitor modulates the proinflammatory macrophage response. Nature. 2012 Aug 16;488(7411):404-8. DMY3SEN RU https://pubmed.ncbi.nlm.nih.gov/22842901 DMHJU7A DI DMHJU7A DMHJU7A DN GSK-LSD1 DMHJU7A MI TTNR0UQ DMHJU7A MN Lysine-specific histone demethylase 1 (LSD) DMHJU7A MT DTT DMHJU7A MA Inhibitor DMHJU7A RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2669). DMHJU7A RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2669 DMNMITH DI DMNMITH DMNMITH DN GT-1282 DMNMITH MI TT2CEJG DMNMITH MN C-C chemokine receptor type 5 (CCR5) DMNMITH MT DTT DMNMITH MA Inhibitor DMNMITH RN Reduced cardiac side-effect potential by introduction of polar groups: discovery of NIBR-1282, an orally bioavailable CCR5 antagonist which is acti... Bioorg Med Chem Lett. 2008 Mar 15;18(6):2000-5. DMNMITH RU https://pubmed.ncbi.nlm.nih.gov/18267361 DMH3PDG DI DMH3PDG DMH3PDG DN GT2394 DMH3PDG MI TT9JNIC DMH3PDG MN Histamine H3 receptor (H3R) DMH3PDG MT DTT DMH3PDG MA Antagonist DMH3PDG RN Characteristics of recombinantly expressed rat and human histamine H3 receptors. Eur J Pharmacol. 2002 Oct 18;453(1):33-41. DMH3PDG RU https://pubmed.ncbi.nlm.nih.gov/12393057 DMW23Y9 DI DMW23Y9 DMW23Y9 DN GTP-14564 DMW23Y9 MI TTVW6QL DMW23Y9 MN CSF1R messenger RNA (CSF1R mRNA) DMW23Y9 MT DTT DMW23Y9 MA Inhibitor DMW23Y9 RN Selective cytotoxic mechanism of GTP-14564, a novel tyrosine kinase inhibitor in leukemia cells expressing a constitutively active Fms-like tyrosin... J Biol Chem. 2003 Aug 29;278(35):32892-8. DMW23Y9 RU https://pubmed.ncbi.nlm.nih.gov/12815052 DMW23Y9 DI DMW23Y9 DMW23Y9 DN GTP-14564 DMW23Y9 MI TTGJCWZ DMW23Y9 MN Fms-like tyrosine kinase 3 (FLT-3) DMW23Y9 MT DTT DMW23Y9 MA Inhibitor DMW23Y9 RN Selective cytotoxic mechanism of GTP-14564, a novel tyrosine kinase inhibitor in leukemia cells expressing a constitutively active Fms-like tyrosin... J Biol Chem. 2003 Aug 29;278(35):32892-8. DMW23Y9 RU https://pubmed.ncbi.nlm.nih.gov/12815052 DMW23Y9 DI DMW23Y9 DMW23Y9 DN GTP-14564 DMW23Y9 MI TTI7421 DMW23Y9 MN Platelet-derived growth factor receptor beta (PDGFRB) DMW23Y9 MT DTT DMW23Y9 MA Inhibitor DMW23Y9 RN Selective cytotoxic mechanism of GTP-14564, a novel tyrosine kinase inhibitor in leukemia cells expressing a constitutively active Fms-like tyrosin... J Biol Chem. 2003 Aug 29;278(35):32892-8. DMW23Y9 RU https://pubmed.ncbi.nlm.nih.gov/12815052 DMW23Y9 DI DMW23Y9 DMW23Y9 DN GTP-14564 DMW23Y9 MI TTX41N9 DMW23Y9 MN Tyrosine-protein kinase Kit (KIT) DMW23Y9 MT DTT DMW23Y9 MA Inhibitor DMW23Y9 RN Selective cytotoxic mechanism of GTP-14564, a novel tyrosine kinase inhibitor in leukemia cells expressing a constitutively active Fms-like tyrosin... J Biol Chem. 2003 Aug 29;278(35):32892-8. DMW23Y9 RU https://pubmed.ncbi.nlm.nih.gov/12815052 DMJUXKY DI DMJUXKY DMJUXKY DN GTPgammaS DMJUXKY MI TTST1AJ DMJUXKY MN Chloride channel protein 7 (ClC-7) DMJUXKY MT DTT DMJUXKY MA Activator DMJUXKY RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 709). DMJUXKY RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=709 DMJUXKY DI DMJUXKY DMJUXKY DN GTPgammaS DMJUXKY MI TT0FC1V DMJUXKY MN Volume regulated chloride channel (VRAC) DMJUXKY MT DTT DMJUXKY MA Activator DMJUXKY RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 710). DMJUXKY RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=710 DMZQETV DI DMZQETV DMZQETV DN GTPL8662 DMZQETV MI TTUV8G9 DMZQETV MN Progesterone receptor (PGR) DMZQETV MT DTT DMZQETV MA Antagonist DMZQETV RN A new strategy for selective targeting of progesterone receptor with passive antagonists. Mol Endocrinol. 2013 Jun;27(6):909-24. DMZQETV RU https://pubmed.ncbi.nlm.nih.gov/23579486 DM315VL DI DM315VL DM315VL DN GTx-027 DM315VL MI TTS64P2 DM315VL MN Androgen receptor (AR) DM315VL MT DTT DM315VL MA Modulator DM315VL RN Selective androgen receptor modulators (SARMs) negatively regulate triple-negative breast cancer growth and epithelial:mesenchymal stem cell signaling. PLoS One. 2014 Jul 29;9(7):e103202. DM315VL RU https://pubmed.ncbi.nlm.nih.gov/25072326 DMEIMVW DI DMEIMVW DMEIMVW DN GTx-822 DMEIMVW MI TTOM3J0 DMEIMVW MN Estrogen receptor beta (ESR2) DMEIMVW MT DTT DMEIMVW MA Modulator DMEIMVW RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 621). DMEIMVW RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=621 DMP9OGC DI DMP9OGC DMP9OGC DN GTx-878 DMP9OGC MI TTOM3J0 DMP9OGC MN Estrogen receptor beta (ESR2) DMP9OGC MT DTT DMP9OGC MA Agonist DMP9OGC RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 621). DMP9OGC RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=621 DMGYMW4 DI DMGYMW4 DMGYMW4 DN Guajazulen DMGYMW4 MI DEJGDUW DMGYMW4 MN Cytochrome P450 1A2 (CYP1A2) DMGYMW4 MT DME DMGYMW4 MA Metabolism DMGYMW4 RN The influence of the sparteine/debrisoquine genetic polymorphism on the disposition of dexfenfluramine. Br J Clin Pharmacol. 1996 Apr;41(4):311-7. DMGYMW4 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=8730977 DM4GO8H DI DM4GO8H DM4GO8H DN Guanidine DM4GO8H MI DT6201N DM4GO8H MN Organic cation transporter 3 (SLC22A3) DM4GO8H MT DTP DM4GO8H MA Substrate DM4GO8H RN Structure, function, and regional distribution of the organic cation transporter OCT3 in the kidney. Am J Physiol Renal Physiol. 2000 Sep;279(3):F449-58. DM4GO8H RU http://www.ncbi.nlm.nih.gov/pubmed/10966924 DMCN56S DI DMCN56S DMCN56S DN GUANOSINE-2',3'-O-ETHYLIDENEPHOSPHONATE DMCN56S MI TTMCF1Y DMCN56S MN Purine nucleoside phosphorylase (PNP) DMCN56S MT DTT DMCN56S MA Inhibitor DMCN56S RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DMCN56S RU https://pubmed.ncbi.nlm.nih.gov/10592235 DMRITFU DI DMRITFU DMRITFU DN GUANOSINE-2',3'-O-METHYLIDENEPHOSPHONATE DMRITFU MI TTMCF1Y DMRITFU MN Purine nucleoside phosphorylase (PNP) DMRITFU MT DTT DMRITFU MA Inhibitor DMRITFU RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DMRITFU RU https://pubmed.ncbi.nlm.nih.gov/10592235 DMG2ZFV DI DMG2ZFV DMG2ZFV DN Guanosine-5',3'-Tetraphosphate DMG2ZFV MI TTBL49X DMG2ZFV MN Plasmodium Hypoxanthine-guanine phosphoribosyltransferase (Malaria LACZ) DMG2ZFV MT DTT DMG2ZFV MA Inhibitor DMG2ZFV RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMG2ZFV RU https://pubmed.ncbi.nlm.nih.gov/17139284 DM0MUKQ DI DM0MUKQ DM0MUKQ DN Guanosine-5'-Diphosphate DM0MUKQ MI TT4W1VJ DM0MUKQ MN Bacterial Celldivision protein FtsZ (Bact ftsZ) DM0MUKQ MT DTT DM0MUKQ MA Inhibitor DM0MUKQ RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DM0MUKQ RU https://pubmed.ncbi.nlm.nih.gov/17139284 DM0MUKQ DI DM0MUKQ DM0MUKQ DN Guanosine-5'-Diphosphate DM0MUKQ MI TTO3MV6 DM0MUKQ MN Bacterial GTP-binding protein YihA (Bact engB) DM0MUKQ MT DTT DM0MUKQ MA Inhibitor DM0MUKQ RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DM0MUKQ RU https://pubmed.ncbi.nlm.nih.gov/17139284 DM0MUKQ DI DM0MUKQ DM0MUKQ DN Guanosine-5'-Diphosphate DM0MUKQ MI TTCNGJ5 DM0MUKQ MN Candida Elongation factor 2 (Candi EFT2) DM0MUKQ MT DTT DM0MUKQ MA Inhibitor DM0MUKQ RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DM0MUKQ RU https://pubmed.ncbi.nlm.nih.gov/17139284 DM0MUKQ DI DM0MUKQ DM0MUKQ DN Guanosine-5'-Diphosphate DM0MUKQ MI TTYQ4AE DM0MUKQ MN Plasmodium Adenylosuccinate synthetase (Malaria Adss) DM0MUKQ MT DTT DM0MUKQ MA Inhibitor DM0MUKQ RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DM0MUKQ RU https://pubmed.ncbi.nlm.nih.gov/17139284 DM0MUKQ DI DM0MUKQ DM0MUKQ DN Guanosine-5'-Diphosphate DM0MUKQ MI TTG45NU DM0MUKQ MN Plasmodium Elongation factor 1-alpha 1 (Malaria MEF-1) DM0MUKQ MT DTT DM0MUKQ MA Inhibitor DM0MUKQ RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DM0MUKQ RU https://pubmed.ncbi.nlm.nih.gov/17139284 DM0MUKQ DI DM0MUKQ DM0MUKQ DN Guanosine-5'-Diphosphate DM0MUKQ MI TT958S6 DM0MUKQ MN Ras-related protein Rab-9A (RAB9A) DM0MUKQ MT DTT DM0MUKQ MA Inhibitor DM0MUKQ RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DM0MUKQ RU https://pubmed.ncbi.nlm.nih.gov/17139284 DM0MUKQ DI DM0MUKQ DM0MUKQ DN Guanosine-5'-Diphosphate DM0MUKQ MI TT6HP1T DM0MUKQ MN Streptococcus Elongation factor G (Stre-coc fusA) DM0MUKQ MT DTT DM0MUKQ MA Inhibitor DM0MUKQ RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DM0MUKQ RU https://pubmed.ncbi.nlm.nih.gov/17139284 DM0MUKQ DI DM0MUKQ DM0MUKQ DN Guanosine-5'-Diphosphate DM0MUKQ MI TT2F4OL DM0MUKQ MN Tissue transglutaminase (TG2) DM0MUKQ MT DTT DM0MUKQ MA Inhibitor DM0MUKQ RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DM0MUKQ RU https://pubmed.ncbi.nlm.nih.gov/17139284 DM3SLZK DI DM3SLZK DM3SLZK DN Guanosine-5'-Monophosphate DM3SLZK MI TT1U2YM DM3SLZK MN Cytomegalovirus DNA polymerase (CMV UL54) DM3SLZK MT DTT DM3SLZK MA Inhibitor DM3SLZK RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DM3SLZK RU https://pubmed.ncbi.nlm.nih.gov/17139284 DM3SLZK DI DM3SLZK DM3SLZK DN Guanosine-5'-Monophosphate DM3SLZK MI TTIU7X1 DM3SLZK MN Herpes simplex virus DNA polymerase UL30 (HSV UL30) DM3SLZK MT DTT DM3SLZK MA Inhibitor DM3SLZK RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DM3SLZK RU https://pubmed.ncbi.nlm.nih.gov/17139284 DM3SLZK DI DM3SLZK DM3SLZK DN Guanosine-5'-Monophosphate DM3SLZK MI TTJ0IQB DM3SLZK MN Phosphodiesterase 5A (PDE5A) DM3SLZK MT DTT DM3SLZK MA Inhibitor DM3SLZK RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DM3SLZK RU https://pubmed.ncbi.nlm.nih.gov/17139284 DM3SLZK DI DM3SLZK DM3SLZK DN Guanosine-5'-Monophosphate DM3SLZK MI TTBL49X DM3SLZK MN Plasmodium Hypoxanthine-guanine phosphoribosyltransferase (Malaria LACZ) DM3SLZK MT DTT DM3SLZK MA Inhibitor DM3SLZK RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DM3SLZK RU https://pubmed.ncbi.nlm.nih.gov/17139284 DM3SLZK DI DM3SLZK DM3SLZK DN Guanosine-5'-Monophosphate DM3SLZK MI TT9PB26 DM3SLZK MN Presynaptic density protein 95 (DLG4) DM3SLZK MT DTT DM3SLZK MA Inhibitor DM3SLZK RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DM3SLZK RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMV2OJX DI DMV2OJX DMV2OJX DN Guanosine-5'-Triphosphate DMV2OJX MI TTO3MV6 DMV2OJX MN Bacterial GTP-binding protein YihA (Bact engB) DMV2OJX MT DTT DMV2OJX MA Inhibitor DMV2OJX RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMV2OJX RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMV2OJX DI DMV2OJX DMV2OJX DN Guanosine-5'-Triphosphate DMV2OJX MI TTLSWP6 DMV2OJX MN GTP cyclohydrolase-I (GCH1) DMV2OJX MT DTT DMV2OJX MA Inhibitor DMV2OJX RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMV2OJX RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMV2OJX DI DMV2OJX DMV2OJX DN Guanosine-5'-Triphosphate DMV2OJX MI TTSUKYD DMV2OJX MN Virus RNA-dependent RNA polymerase (Viru RdRP) DMV2OJX MT DTT DMV2OJX MA Inhibitor DMV2OJX RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMV2OJX RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMOUQLB DI DMOUQLB DMOUQLB DN guanylpirenzepine DMOUQLB MI TTOXS3C DMOUQLB MN Muscarinic acetylcholine receptor (CHRM) DMOUQLB MT DTT DMOUQLB MA Antagonist DMOUQLB RN Subtypes of muscarinic receptors in rat duodenum: a comparison with rabbit vas deferens, rat atria, guinea-pig ileum and gallbladder by using imperialine. Gen Pharmacol. 1999 Apr;32(4):505-11. DMOUQLB RU https://pubmed.ncbi.nlm.nih.gov/10323493 DMOUQLB DI DMOUQLB DMOUQLB DN guanylpirenzepine DMOUQLB MI TTQ13Z5 DMOUQLB MN Muscarinic acetylcholine receptor M3 (CHRM3) DMOUQLB MT DTT DMOUQLB MA Antagonist DMOUQLB RN Binding of the labelled muscarinic toxin 125I-MT1 to rat brain muscarinic M1 receptors. Eur J Pharmacol. 1996 Jun 3;305(1-3):187-92. DMOUQLB RU https://pubmed.ncbi.nlm.nih.gov/8813552 DM89KNT DI DM89KNT DM89KNT DN Gue1654 DM89KNT MI TT7WBSV DM89KNT MN Oxoeicosanoid receptor 1 (OXER1) DM89KNT MT DTT DM89KNT MA Modulator (allosteric modulator) DM89KNT RN A biased ligand for OXE-R uncouples Galpha and Gbetagamma signaling within a heterotrimer. Nat Chem Biol. 2012 Jul;8(7):631-8. DM89KNT RU https://pubmed.ncbi.nlm.nih.gov/22634634 DMBXGVH DI DMBXGVH DMBXGVH DN Guttiferone I DMBXGVH MI TTECBXN DMBXGVH MN Oxysterols receptor LXR-alpha (NR1H3) DMBXGVH MT DTT DMBXGVH MA Inhibitor DMBXGVH RN Guttiferone I, a new prenylated benzophenone from Garcinia humilis as a liver X receptor ligand. J Nat Prod. 2005 Apr;68(4):617-9. DMBXGVH RU https://pubmed.ncbi.nlm.nih.gov/15844964 DM78KYC DI DM78KYC DM78KYC DN GW 627368 DM78KYC MI TT79WV3 DM78KYC MN Prostaglandin E2 receptor EP4 (PTGER4) DM78KYC MT DTT DM78KYC MA Antagonist DM78KYC RN Piglet saphenous vein contains multiple relaxatory prostanoid receptors: evidence for EP4, EP2, DP and IP receptor subtypes. Br J Pharmacol. 2005 Feb;144(3):405-15. DM78KYC RU https://pubmed.ncbi.nlm.nih.gov/15655509 DM3D2R4 DI DM3D2R4 DM3D2R4 DN GW0072 DM3D2R4 MI TTT2SVW DM3D2R4 MN PPAR-gamma messenger RNA (PPARG mRNA) DM3D2R4 MT DTT DM3D2R4 MA Agonist DM3D2R4 RN A peroxisome proliferator-activated receptor gamma ligand inhibits adipocyte differentiation. Proc Natl Acad Sci U S A. 1999 May 25;96(11):6102-6. DM3D2R4 RU https://pubmed.ncbi.nlm.nih.gov/10339548 DMGKEO5 DI DMGKEO5 DMGKEO5 DN GW0742X DMGKEO5 MI TT2JWF6 DMGKEO5 MN Peroxisome proliferator-activated receptor delta (PPARD) DMGKEO5 MT DTT DMGKEO5 MA Agonist DMGKEO5 RN Novel selective small molecule agonists for peroxisome proliferator-activated receptor delta (PPARdelta)--synthesis and biological activity. Bioorg Med Chem Lett. 2003 May 5;13(9):1517-21. DMGKEO5 RU https://pubmed.ncbi.nlm.nih.gov/12699745 DM3DXM0 DI DM3DXM0 DM3DXM0 DN GW1100 DM3DXM0 MI TTB8FUC DM3DXM0 MN Free fatty acid receptor 1 (GPR40) DM3DXM0 MT DTT DM3DXM0 MA Antagonist DM3DXM0 RN Pharmacological regulation of insulin secretion in MIN6 cells through the fatty acid receptor GPR40: identification of agonist and antagonist small... Br J Pharmacol. 2006 Jul;148(5):619-28. DM3DXM0 RU https://pubmed.ncbi.nlm.nih.gov/16702987 DMOV980 DI DMOV980 DMOV980 DN GW1929 DMOV980 MI TTT2SVW DMOV980 MN PPAR-gamma messenger RNA (PPARG mRNA) DMOV980 MT DTT DMOV980 MA Agonist DMOV980 RN A novel N-aryl tyrosine activator of peroxisome proliferator-activated receptor-gamma reverses the diabetic phenotype of the Zucker diabetic fatty rat. Diabetes. 1999 Jul;48(7):1415-24. DMOV980 RU https://pubmed.ncbi.nlm.nih.gov/10389847 DMM8V9E DI DMM8V9E DMM8V9E DN GW-2331 DMM8V9E MI TTJ584C DMM8V9E MN Peroxisome proliferator-activated receptor alpha (PPARA) DMM8V9E MT DTT DMM8V9E MA Modulator DMM8V9E RN PPAR-alpha and -gamma but not -delta agonists inhibit airway inflammation in a murine model of asthma: in vitro evidence for an NF-kappaB-independe... Br J Pharmacol. 2003 May;139(1):163-71. DMM8V9E RU https://www.ncbi.nlm.nih.gov/pubmed/12746235 DMM8V9E DI DMM8V9E DMM8V9E DN GW-2331 DMM8V9E MI TTZMAO3 DMM8V9E MN Peroxisome proliferator-activated receptor gamma (PPAR-gamma) DMM8V9E MT DTT DMM8V9E MA Modulator DMM8V9E RN PPAR-alpha and -gamma but not -delta agonists inhibit airway inflammation in a murine model of asthma: in vitro evidence for an NF-kappaB-independe... Br J Pharmacol. 2003 May;139(1):163-71. DMM8V9E RU https://www.ncbi.nlm.nih.gov/pubmed/12746235 DMEAIQC DI DMEAIQC DMEAIQC DN GW2433 DMEAIQC MI TT2JWF6 DMEAIQC MN Peroxisome proliferator-activated receptor delta (PPARD) DMEAIQC MT DTT DMEAIQC MA Agonist DMEAIQC RN Identification of peroxisome proliferator-activated receptor ligands from a biased chemical library. Chem Biol. 1997 Dec;4(12):909-18. DMEAIQC RU https://pubmed.ncbi.nlm.nih.gov/9427656 DMTW9GM DI DMTW9GM DMTW9GM DN GW-2580 DMTW9GM MI TTVW6QL DMTW9GM MN CSF1R messenger RNA (CSF1R mRNA) DMTW9GM MT DTT DMTW9GM MA Inhibitor DMTW9GM RN Inhibition of colony-stimulating-factor-1 signaling in vivo with the orally bioavailable cFMS kinase inhibitor GW2580. Proc Natl Acad Sci U S A. 2005 Nov 1;102(44):16078-83. DMTW9GM RU https://pubmed.ncbi.nlm.nih.gov/16249345 DMG60ET DI DMG60ET DMG60ET DN GW-3965 DMG60ET MI TTECBXN DMG60ET MN Oxysterols receptor LXR-alpha (NR1H3) DMG60ET MT DTT DMG60ET MA Inhibitor DMG60ET RN Indazole-based liver X receptor (LXR) modulators with maintained atherosclerotic lesion reduction activity but diminished stimulation of hepatic tr... J Med Chem. 2008 Nov 27;51(22):7161-8. DMG60ET RU https://pubmed.ncbi.nlm.nih.gov/18973288 DMG60ET DI DMG60ET DMG60ET DN GW-3965 DMG60ET MI TTXA6PH DMG60ET MN Oxysterols receptor LXR-beta (NR1H2) DMG60ET MT DTT DMG60ET MA Inhibitor DMG60ET RN Indazole-based liver X receptor (LXR) modulators with maintained atherosclerotic lesion reduction activity but diminished stimulation of hepatic tr... J Med Chem. 2008 Nov 27;51(22):7161-8. DMG60ET RU https://pubmed.ncbi.nlm.nih.gov/18973288 DMFRP7H DI DMFRP7H DMFRP7H DN GW4065 DMFRP7H MI TTS4UGC DMFRP7H MN Farnesoid X-activated receptor (FXR) DMFRP7H MT DTT DMFRP7H MA Agonist DMFRP7H RN Lithocholic acid decreases expression of bile salt export pump through farnesoid X receptor antagonist activity. J Biol Chem. 2002 Aug 30;277(35):31441-7. DMFRP7H RU https://pubmed.ncbi.nlm.nih.gov/12052824 DMIHOYF DI DMIHOYF DMIHOYF DN GW-5074 DMIHOYF MI TTAN5W2 DMIHOYF MN Raf messenger RNA (Raf mRNA) DMIHOYF MT DTT DMIHOYF MA Inhibitor DMIHOYF RN Discovery and in vitro evaluation of potent TrkA kinase inhibitors: oxindole and aza-oxindoles. Bioorg Med Chem Lett. 2004 Feb 23;14(4):953-7. DMIHOYF RU https://pubmed.ncbi.nlm.nih.gov/15013000 DMIHOYF DI DMIHOYF DMIHOYF DN GW-5074 DMIHOYF MI TTTDVOJ DMIHOYF MN Tropomyosin-related kinase A (TrkA) DMIHOYF MT DTT DMIHOYF MA Inhibitor DMIHOYF RN Discovery and in vitro evaluation of potent TrkA kinase inhibitors: oxindole and aza-oxindoles. Bioorg Med Chem Lett. 2004 Feb 23;14(4):953-7. DMIHOYF RU https://pubmed.ncbi.nlm.nih.gov/15013000 DMGRKT4 DI DMGRKT4 DMGRKT4 DN GW-559768X DMGRKT4 MI TT4DXQT DMGRKT4 MN Proto-oncogene c-Ret (RET) DMGRKT4 MT DTT DMGRKT4 MA Inhibitor DMGRKT4 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2185). DMGRKT4 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2185 DMCOYF9 DI DMCOYF9 DMCOYF9 DN GW-5823 DMCOYF9 MI TTCG0AL DMCOYF9 MN Cholecystokinin receptor type A (CCKAR) DMCOYF9 MT DTT DMCOYF9 MA Agonist DMCOYF9 RN Optimization of 3-(1H-indazol-3-ylmethyl)-1,5-benzodiazepines as potent, orally active CCK-A agonists. J Med Chem. 1997 Aug 15;40(17):2706-25. DMCOYF9 RU https://pubmed.ncbi.nlm.nih.gov/9276016 DMCOYF9 DI DMCOYF9 DMCOYF9 DN GW-5823 DMCOYF9 MI TTVFO0U DMCOYF9 MN Gastrin/cholecystokinin type B receptor (CCKBR) DMCOYF9 MT DTT DMCOYF9 MA Antagonist DMCOYF9 RN Optimization of 3-(1H-indazol-3-ylmethyl)-1,5-benzodiazepines as potent, orally active CCK-A agonists. J Med Chem. 1997 Aug 15;40(17):2706-25. DMCOYF9 RU https://pubmed.ncbi.nlm.nih.gov/9276016 DMX59A0 DI DMX59A0 DMX59A0 DN GW-637185X DMX59A0 MI TTVKILB DMX59A0 MN Prostaglandin G/H synthase 2 (COX-2) DMX59A0 MT DTT DMX59A0 MA Inhibitor DMX59A0 RN Identification of [4-[4-(methylsulfonyl)phenyl]-6-(trifluoromethyl)-2-pyrimidinyl] amines and ethers as potent and selective cyclooxygenase-2 inhib... Bioorg Med Chem Lett. 2009 Aug 1;19(15):4504-8. DMX59A0 RU https://pubmed.ncbi.nlm.nih.gov/19520573 DMCA4RM DI DMCA4RM DMCA4RM DN GW7604 DMCA4RM MI TTZAYWL DMCA4RM MN Estrogen receptor (ESR) DMCA4RM MT DTT DMCA4RM MA Antagonist DMCA4RM RN Molecular mechanism of action at estrogen receptor alpha of a new clinically relevant antiestrogen (GW7604) related to tamoxifen. Endocrinology. 2001 Feb;142(2):838-46. DMCA4RM RU https://pubmed.ncbi.nlm.nih.gov/11159857 DM9RD0C DI DM9RD0C DM9RD0C DN GW7647 DM9RD0C MI TTJ584C DM9RD0C MN Peroxisome proliferator-activated receptor alpha (PPARA) DM9RD0C MT DTT DM9RD0C MA Agonist DM9RD0C RN Identification of a subtype selective human PPARalpha agonist through parallel-array synthesis. Bioorg Med Chem Lett. 2001 May 7;11(9):1225-7. DM9RD0C RU https://pubmed.ncbi.nlm.nih.gov/11354382 DMEK2I4 DI DMEK2I4 DMEK2I4 DN GW7845 DMEK2I4 MI TTZMAO3 DMEK2I4 MN Peroxisome proliferator-activated receptor gamma (PPAR-gamma) DMEK2I4 MT DTT DMEK2I4 MA Agonist DMEK2I4 RN A new ligand for the peroxisome proliferator-activated receptor-gamma (PPAR-gamma), GW7845, inhibits rat mammary carcinogenesis. Cancer Res. 1999 Nov 15;59(22):5671-3. DMEK2I4 RU https://pubmed.ncbi.nlm.nih.gov/10582681 DMIBUW5 DI DMIBUW5 DMIBUW5 DN GW-788388 DMIBUW5 MI TT860QF DMIBUW5 MN LCK tyrosine protein kinase (LCK) DMIBUW5 MT DTT DMIBUW5 MA Inhibitor DMIBUW5 RN Discovery of 4-{4-[3-(pyridin-2-yl)-1H-pyrazol-4-yl]pyridin-2-yl}-N-(tetrahydro-2H- pyran-4-yl)benzamide (GW788388): a potent, selective, and orall... J Med Chem. 2006 Apr 6;49(7):2210-21. DMIBUW5 RU https://pubmed.ncbi.nlm.nih.gov/16570917 DMIBUW5 DI DMIBUW5 DMIBUW5 DN GW-788388 DMIBUW5 MI TTQBR95 DMIBUW5 MN Stress-activated protein kinase 2a (p38 alpha) DMIBUW5 MT DTT DMIBUW5 MA Inhibitor DMIBUW5 RN Discovery of 4-{4-[3-(pyridin-2-yl)-1H-pyrazol-4-yl]pyridin-2-yl}-N-(tetrahydro-2H- pyran-4-yl)benzamide (GW788388): a potent, selective, and orall... J Med Chem. 2006 Apr 6;49(7):2210-21. DMIBUW5 RU https://pubmed.ncbi.nlm.nih.gov/16570917 DMIBUW5 DI DMIBUW5 DMIBUW5 DN GW-788388 DMIBUW5 MI TTP4520 DMIBUW5 MN TGF-beta receptor type I (TGFBR1) DMIBUW5 MT DTT DMIBUW5 MA Inhibitor DMIBUW5 RN Discovery of 4-{4-[3-(pyridin-2-yl)-1H-pyrazol-4-yl]pyridin-2-yl}-N-(tetrahydro-2H- pyran-4-yl)benzamide (GW788388): a potent, selective, and orall... J Med Chem. 2006 Apr 6;49(7):2210-21. DMIBUW5 RU https://pubmed.ncbi.nlm.nih.gov/16570917 DMWAEJ3 DI DMWAEJ3 DMWAEJ3 DN GW803430 DMWAEJ3 MI TTX4RTB DMWAEJ3 MN Melanin-concentrating hormone receptor 1 (MCHR1) DMWAEJ3 MT DTT DMWAEJ3 MA Antagonist DMWAEJ3 RN The discovery and optimization of pyrimidinone-containing MCH R1 antagonists. Bioorg Med Chem Lett. 2006 Sep 15;16(18):4723-7. DMWAEJ3 RU https://pubmed.ncbi.nlm.nih.gov/16870432 DMWAEJ3 DI DMWAEJ3 DMWAEJ3 DN GW803430 DMWAEJ3 MI TTQ6VDM DMWAEJ3 MN Voltage-gated potassium channel Kv11.1 (KCNH2) DMWAEJ3 MT DTT DMWAEJ3 MA Inhibitor DMWAEJ3 RN Novel approach for chemotype hopping based on annotated databases of chemically feasible fragments and a prospective case study: new melanin concen... J Med Chem. 2009 Apr 9;52(7):2076-89. DMWAEJ3 RU https://pubmed.ncbi.nlm.nih.gov/19290642 DMRL9IN DI DMRL9IN DMRL9IN DN GW841819X DMRL9IN MI TTDP48B DMRL9IN MN Bromodomain-containing protein 2 (BRD2) DMRL9IN MT DTT DMRL9IN MA Inhibitor DMRL9IN RN Discovery and characterization of small molecule inhibitors of the BET family bromodomains. J Med Chem. 2011 Jun 9;54(11):3827-38. DMRL9IN RU https://pubmed.ncbi.nlm.nih.gov/21568322 DMRL9IN DI DMRL9IN DMRL9IN DN GW841819X DMRL9IN MI TTHE657 DMRL9IN MN Bromodomain-containing protein 3 (BRD3) DMRL9IN MT DTT DMRL9IN MA Inhibitor DMRL9IN RN Discovery and characterization of small molecule inhibitors of the BET family bromodomains. J Med Chem. 2011 Jun 9;54(11):3827-38. DMRL9IN RU https://pubmed.ncbi.nlm.nih.gov/21568322 DMRL9IN DI DMRL9IN DMRL9IN DN GW841819X DMRL9IN MI TTRA6BO DMRL9IN MN Bromodomain-containing protein 4 (BRD4) DMRL9IN MT DTT DMRL9IN MA Inhibitor DMRL9IN RN Discovery and characterization of small molecule inhibitors of the BET family bromodomains. J Med Chem. 2011 Jun 9;54(11):3827-38. DMRL9IN RU https://pubmed.ncbi.nlm.nih.gov/21568322 DMXA5M9 DI DMXA5M9 DMXA5M9 DN GW848687X DMXA5M9 MI TTG1QMU DMXA5M9 MN Prostaglandin E2 receptor EP1 (PTGER1) DMXA5M9 MT DTT DMXA5M9 MA Antagonist DMXA5M9 RN The discovery of 6-[2-(5-chloro-2-{[(2,4-difluorophenyl)methyl]oxy}phenyl)-1-cyclopenten-1-yl]-2-pyridinecarboxylic acid, GW848687X, a potent and s... Bioorg Med Chem Lett. 2007 Jan 15;17(2):385-9. DMXA5M9 RU https://pubmed.ncbi.nlm.nih.gov/17084082 DML4UMT DI DML4UMT DML4UMT DN GW-8510 DML4UMT MI TTAMQ62 DML4UMT MN Cyclin A2 (CCNA2) DML4UMT MT DTT DML4UMT MA Inhibitor DML4UMT RN Discovery and in vitro evaluation of potent TrkA kinase inhibitors: oxindole and aza-oxindoles. Bioorg Med Chem Lett. 2004 Feb 23;14(4):953-7. DML4UMT RU https://pubmed.ncbi.nlm.nih.gov/15013000 DML4UMT DI DML4UMT DML4UMT DN GW-8510 DML4UMT MI TT7HF4W DML4UMT MN Cyclin-dependent kinase 2 (CDK2) DML4UMT MT DTT DML4UMT MA Inhibitor DML4UMT RN Discovery and in vitro evaluation of potent TrkA kinase inhibitors: oxindole and aza-oxindoles. Bioorg Med Chem Lett. 2004 Feb 23;14(4):953-7. DML4UMT RU https://pubmed.ncbi.nlm.nih.gov/15013000 DMITKX8 DI DMITKX8 DMITKX8 DN GW853606 DMITKX8 MI TTIYVQP DMITKX8 MN Polo-like kinase 1 (PLK1) DMITKX8 MT DTT DMITKX8 MA Inhibitor DMITKX8 RN Discovery of thiophene inhibitors of polo-like kinase. Bioorg Med Chem Lett. 2009 Feb 1;19(3):1018-21. DMITKX8 RU https://pubmed.ncbi.nlm.nih.gov/19097784 DMVKZ5I DI DMVKZ5I DMVKZ5I DN GW9508 DMVKZ5I MI TTB8FUC DMVKZ5I MN Free fatty acid receptor 1 (GPR40) DMVKZ5I MT DTT DMVKZ5I MA Agonist DMVKZ5I RN Pharmacological regulation of insulin secretion in MIN6 cells through the fatty acid receptor GPR40: identification of agonist and antagonist small... Br J Pharmacol. 2006 Jul;148(5):619-28. DMVKZ5I RU https://pubmed.ncbi.nlm.nih.gov/16702987 DMVKZ5I DI DMVKZ5I DMVKZ5I DN GW9508 DMVKZ5I MI TT08JVB DMVKZ5I MN G-protein coupled receptor 120 (GPR120) DMVKZ5I MT DTT DMVKZ5I MA Agonist DMVKZ5I RN Free fatty acid receptors and drug discovery. Biol Pharm Bull. 2008 Oct;31(10):1847-51. DMVKZ5I RU https://pubmed.ncbi.nlm.nih.gov/18827341 DMPIRE0 DI DMPIRE0 DMPIRE0 DN GwTLNSAGYLLGPHAVGNHRSFSDKNGLTS-CONH2 DMPIRE0 MI TTX3HNZ DMPIRE0 MN Galanin receptor type 1 (GAL1-R) DMPIRE0 MT DTT DMPIRE0 MA Inhibitor DMPIRE0 RN Engineering galanin analogues that discriminate between GalR1 and GalR2 receptor subtypes and exhibit anticonvulsant activity following systemic de... J Med Chem. 2010 Feb 25;53(4):1871-5. DMPIRE0 RU https://pubmed.ncbi.nlm.nih.gov/20121116 DMPIRE0 DI DMPIRE0 DMPIRE0 DN GwTLNSAGYLLGPHAVGNHRSFSDKNGLTS-CONH2 DMPIRE0 MI TTBPW3J DMPIRE0 MN Galanin receptor type 2 (GAL2-R) DMPIRE0 MT DTT DMPIRE0 MA Inhibitor DMPIRE0 RN Engineering galanin analogues that discriminate between GalR1 and GalR2 receptor subtypes and exhibit anticonvulsant activity following systemic de... J Med Chem. 2010 Feb 25;53(4):1871-5. DMPIRE0 RU https://pubmed.ncbi.nlm.nih.gov/20121116 DMZPRIG DI DMZPRIG DMZPRIG DN GWTLNSAGYLLGPHAV-NH2 DMZPRIG MI TTX3HNZ DMZPRIG MN Galanin receptor type 1 (GAL1-R) DMZPRIG MT DTT DMZPRIG MA Inhibitor DMZPRIG RN Design, synthesis, and characterization of high-affinity, systemically-active galanin analogues with potent anticonvulsant activities. J Med Chem. 2008 Dec 25;51(24):8038-47. DMZPRIG RU https://pubmed.ncbi.nlm.nih.gov/19053761 DMZPRIG DI DMZPRIG DMZPRIG DN GWTLNSAGYLLGPHAV-NH2 DMZPRIG MI TTBPW3J DMZPRIG MN Galanin receptor type 2 (GAL2-R) DMZPRIG MT DTT DMZPRIG MA Inhibitor DMZPRIG RN Design, synthesis, and characterization of high-affinity, systemically-active galanin analogues with potent anticonvulsant activities. J Med Chem. 2008 Dec 25;51(24):8038-47. DMZPRIG RU https://pubmed.ncbi.nlm.nih.gov/19053761 DMKFMQ5 DI DMKFMQ5 DMKFMQ5 DN GWTLNSAGYLLGPPPALALA-CONH2 DMKFMQ5 MI TTX3HNZ DMKFMQ5 MN Galanin receptor type 1 (GAL1-R) DMKFMQ5 MT DTT DMKFMQ5 MA Inhibitor DMKFMQ5 RN Engineering galanin analogues that discriminate between GalR1 and GalR2 receptor subtypes and exhibit anticonvulsant activity following systemic de... J Med Chem. 2010 Feb 25;53(4):1871-5. DMKFMQ5 RU https://pubmed.ncbi.nlm.nih.gov/20121116 DMKFMQ5 DI DMKFMQ5 DMKFMQ5 DN GWTLNSAGYLLGPPPALALA-CONH2 DMKFMQ5 MI TTBPW3J DMKFMQ5 MN Galanin receptor type 2 (GAL2-R) DMKFMQ5 MT DTT DMKFMQ5 MA Inhibitor DMKFMQ5 RN Engineering galanin analogues that discriminate between GalR1 and GalR2 receptor subtypes and exhibit anticonvulsant activity following systemic de... J Med Chem. 2010 Feb 25;53(4):1871-5. DMKFMQ5 RU https://pubmed.ncbi.nlm.nih.gov/20121116 DMVWGM2 DI DMVWGM2 DMVWGM2 DN GWTLNSAGYLLGPPPGFSPFR-CONH2 DMVWGM2 MI TTX3HNZ DMVWGM2 MN Galanin receptor type 1 (GAL1-R) DMVWGM2 MT DTT DMVWGM2 MA Inhibitor DMVWGM2 RN Engineering galanin analogues that discriminate between GalR1 and GalR2 receptor subtypes and exhibit anticonvulsant activity following systemic de... J Med Chem. 2010 Feb 25;53(4):1871-5. DMVWGM2 RU https://pubmed.ncbi.nlm.nih.gov/20121116 DMVWGM2 DI DMVWGM2 DMVWGM2 DN GWTLNSAGYLLGPPPGFSPFR-CONH2 DMVWGM2 MI TTBPW3J DMVWGM2 MN Galanin receptor type 2 (GAL2-R) DMVWGM2 MT DTT DMVWGM2 MA Inhibitor DMVWGM2 RN Engineering galanin analogues that discriminate between GalR1 and GalR2 receptor subtypes and exhibit anticonvulsant activity following systemic de... J Med Chem. 2010 Feb 25;53(4):1871-5. DMVWGM2 RU https://pubmed.ncbi.nlm.nih.gov/20121116 DM5YR4S DI DM5YR4S DM5YR4S DN GWTLNSAGYLLGPRHYINLITRQRY-CONH2 DM5YR4S MI TTX3HNZ DM5YR4S MN Galanin receptor type 1 (GAL1-R) DM5YR4S MT DTT DM5YR4S MA Inhibitor DM5YR4S RN Engineering galanin analogues that discriminate between GalR1 and GalR2 receptor subtypes and exhibit anticonvulsant activity following systemic de... J Med Chem. 2010 Feb 25;53(4):1871-5. DM5YR4S RU https://pubmed.ncbi.nlm.nih.gov/20121116 DM5YR4S DI DM5YR4S DM5YR4S DN GWTLNSAGYLLGPRHYINLITRQRY-CONH2 DM5YR4S MI TTBPW3J DM5YR4S MN Galanin receptor type 2 (GAL2-R) DM5YR4S MT DTT DM5YR4S MA Inhibitor DM5YR4S RN Engineering galanin analogues that discriminate between GalR1 and GalR2 receptor subtypes and exhibit anticonvulsant activity following systemic de... J Med Chem. 2010 Feb 25;53(4):1871-5. DM5YR4S RU https://pubmed.ncbi.nlm.nih.gov/20121116 DM48AV3 DI DM48AV3 DM48AV3 DN GWTLNSAGYLLGPrPKPQQwFwLL-CONH2 DM48AV3 MI TTX3HNZ DM48AV3 MN Galanin receptor type 1 (GAL1-R) DM48AV3 MT DTT DM48AV3 MA Inhibitor DM48AV3 RN Engineering galanin analogues that discriminate between GalR1 and GalR2 receptor subtypes and exhibit anticonvulsant activity following systemic de... J Med Chem. 2010 Feb 25;53(4):1871-5. DM48AV3 RU https://pubmed.ncbi.nlm.nih.gov/20121116 DM48AV3 DI DM48AV3 DM48AV3 DN GWTLNSAGYLLGPrPKPQQwFwLL-CONH2 DM48AV3 MI TTBPW3J DM48AV3 MN Galanin receptor type 2 (GAL2-R) DM48AV3 MT DTT DM48AV3 MA Inhibitor DM48AV3 RN Engineering galanin analogues that discriminate between GalR1 and GalR2 receptor subtypes and exhibit anticonvulsant activity following systemic de... J Med Chem. 2010 Feb 25;53(4):1871-5. DM48AV3 RU https://pubmed.ncbi.nlm.nih.gov/20121116 DM8GFJP DI DM8GFJP DM8GFJP DN GX-C4 DM8GFJP MI TTI2S1D DM8GFJP MN Cytotoxic T-lymphocyte protein 4 (CTLA-4) DM8GFJP MT DTT DM8GFJP RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2743). DM8GFJP RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2743 DM1RY6Q DI DM1RY6Q DM1RY6Q DN GX-G6 DM1RY6Q MI TTVIMDE DM1RY6Q MN Glucagon-like peptide 1 receptor (GLP1R) DM1RY6Q MT DTT DM1RY6Q RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 249). DM1RY6Q RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=249 DM7SLAM DI DM7SLAM DM7SLAM DN Gymnochrome E DM7SLAM MI TT6R7JZ DM7SLAM MN Histone deacetylase 1 (HDAC1) DM7SLAM MT DTT DM7SLAM MA Inhibitor DM7SLAM RN Gymnochromes E and F, cytotoxic phenanthroperylenequinones from a deep-water crinoid, Holopus rangii. J Nat Prod. 2010 Apr 23;73(4):712-5. DM7SLAM RU https://pubmed.ncbi.nlm.nih.gov/20158243 DM8ENQZ DI DM8ENQZ DM8ENQZ DN Gypenoside XVII DM8ENQZ MI DEVLXCG DM8ENQZ MN Beta-glucosidase (bglA) DM8ENQZ MT DME DM8ENQZ MA Metabolism DM8ENQZ RN Constitutive beta-glucosidases hydrolyzing ginsenoside Rb1 and Rb2 from human intestinal bacteria. Biol Pharm Bull. 2000 Dec;23(12):1481-5. DM8ENQZ RU https://pubmed.ncbi.nlm.nih.gov/11145182 DM9XK05 DI DM9XK05 DM9XK05 DN H-[Trp-Arg-Nva-Arg-Tyr]2-NH2 DM9XK05 MI TTRK9JT DM9XK05 MN Neuropeptide Y receptor type 1 (NPY1R) DM9XK05 MT DTT DM9XK05 MA Inhibitor DM9XK05 RN Neuropeptide Y (NPY) Y4 receptor selective agonists based on NPY(32-36): development of an anorectic Y4 receptor selective agonist with picomolar a... J Med Chem. 2006 Apr 20;49(8):2661-5. DM9XK05 RU https://pubmed.ncbi.nlm.nih.gov/16610810 DM9XK05 DI DM9XK05 DM9XK05 DN H-[Trp-Arg-Nva-Arg-Tyr]2-NH2 DM9XK05 MI TTJ6WK9 DM9XK05 MN Neuropeptide Y receptor type 2 (NPY2R) DM9XK05 MT DTT DM9XK05 MA Inhibitor DM9XK05 RN Neuropeptide Y (NPY) Y4 receptor selective agonists based on NPY(32-36): development of an anorectic Y4 receptor selective agonist with picomolar a... J Med Chem. 2006 Apr 20;49(8):2661-5. DM9XK05 RU https://pubmed.ncbi.nlm.nih.gov/16610810 DM9XK05 DI DM9XK05 DM9XK05 DN H-[Trp-Arg-Nva-Arg-Tyr]2-NH2 DM9XK05 MI TTW4N16 DM9XK05 MN Neuropeptide Y receptor type 4 (NPY4R) DM9XK05 MT DTT DM9XK05 MA Inhibitor DM9XK05 RN Neuropeptide Y (NPY) Y4 receptor selective agonists based on NPY(32-36): development of an anorectic Y4 receptor selective agonist with picomolar a... J Med Chem. 2006 Apr 20;49(8):2661-5. DM9XK05 RU https://pubmed.ncbi.nlm.nih.gov/16610810 DMKH8PF DI DMKH8PF DMKH8PF DN H-[Trp-Arg-Nva-Arg-Tyr]3-NH2 DMKH8PF MI TTRK9JT DMKH8PF MN Neuropeptide Y receptor type 1 (NPY1R) DMKH8PF MT DTT DMKH8PF MA Inhibitor DMKH8PF RN Neuropeptide Y (NPY) Y4 receptor selective agonists based on NPY(32-36): development of an anorectic Y4 receptor selective agonist with picomolar a... J Med Chem. 2006 Apr 20;49(8):2661-5. DMKH8PF RU https://pubmed.ncbi.nlm.nih.gov/16610810 DMKH8PF DI DMKH8PF DMKH8PF DN H-[Trp-Arg-Nva-Arg-Tyr]3-NH2 DMKH8PF MI TTJ6WK9 DMKH8PF MN Neuropeptide Y receptor type 2 (NPY2R) DMKH8PF MT DTT DMKH8PF MA Inhibitor DMKH8PF RN Neuropeptide Y (NPY) Y4 receptor selective agonists based on NPY(32-36): development of an anorectic Y4 receptor selective agonist with picomolar a... J Med Chem. 2006 Apr 20;49(8):2661-5. DMKH8PF RU https://pubmed.ncbi.nlm.nih.gov/16610810 DMKH8PF DI DMKH8PF DMKH8PF DN H-[Trp-Arg-Nva-Arg-Tyr]3-NH2 DMKH8PF MI TTW4N16 DMKH8PF MN Neuropeptide Y receptor type 4 (NPY4R) DMKH8PF MT DTT DMKH8PF MA Inhibitor DMKH8PF RN Neuropeptide Y (NPY) Y4 receptor selective agonists based on NPY(32-36): development of an anorectic Y4 receptor selective agonist with picomolar a... J Med Chem. 2006 Apr 20;49(8):2661-5. DMKH8PF RU https://pubmed.ncbi.nlm.nih.gov/16610810 DMYOADQ DI DMYOADQ DMYOADQ DN H-2',6'-dimethyltyrosine-Tic-OH DMYOADQ MI TT27RFC DMYOADQ MN Opioid receptor delta (OPRD1) DMYOADQ MT DTT DMYOADQ MA Inhibitor DMYOADQ RN Agonist vs antagonist behavior of delta opioid peptides containing novel phenylalanine analogues in place of Tyr(1). J Med Chem. 2009 Nov 12;52(21):6941-5. DMYOADQ RU https://pubmed.ncbi.nlm.nih.gov/19827750 DMYOADQ DI DMYOADQ DMYOADQ DN H-2',6'-dimethyltyrosine-Tic-OH DMYOADQ MI TTKWM86 DMYOADQ MN Opioid receptor mu (MOP) DMYOADQ MT DTT DMYOADQ MA Inhibitor DMYOADQ RN Agonist vs antagonist behavior of delta opioid peptides containing novel phenylalanine analogues in place of Tyr(1). J Med Chem. 2009 Nov 12;52(21):6941-5. DMYOADQ RU https://pubmed.ncbi.nlm.nih.gov/19827750 DM7IEU2 DI DM7IEU2 DM7IEU2 DN H-2',6'-dimethyltyrosine-Tic-Phe-Phe-OH DM7IEU2 MI TT27RFC DM7IEU2 MN Opioid receptor delta (OPRD1) DM7IEU2 MT DTT DM7IEU2 MA Inhibitor DM7IEU2 RN Agonist vs antagonist behavior of delta opioid peptides containing novel phenylalanine analogues in place of Tyr(1). J Med Chem. 2009 Nov 12;52(21):6941-5. DM7IEU2 RU https://pubmed.ncbi.nlm.nih.gov/19827750 DM7IEU2 DI DM7IEU2 DM7IEU2 DN H-2',6'-dimethyltyrosine-Tic-Phe-Phe-OH DM7IEU2 MI TTKWM86 DM7IEU2 MN Opioid receptor mu (MOP) DM7IEU2 MT DTT DM7IEU2 MA Inhibitor DM7IEU2 RN Agonist vs antagonist behavior of delta opioid peptides containing novel phenylalanine analogues in place of Tyr(1). J Med Chem. 2009 Nov 12;52(21):6941-5. DM7IEU2 RU https://pubmed.ncbi.nlm.nih.gov/19827750 DMOJI0N DI DMOJI0N DMOJI0N DN H22xKi-4 DMOJI0N MI TT2GM5R DMOJI0N MN Lymphocyte activation antigen CD30 (TNFRSF8) DMOJI0N MT DTT DMOJI0N RN Phase 1 trial of the novel bispecific molecule H22xKi-4 in patients with refractory Hodgkin lymphoma. Blood. 2002 Nov 1;100(9):3101-7. DMOJI0N RU https://pubmed.ncbi.nlm.nih.gov/12384405 DM80QF9 DI DM80QF9 DM80QF9 DN H-8 DM80QF9 MI TTHIQMC DM80QF9 MN Cyclic nucleotide-gated channel alpha-1 (CNGA1) DM80QF9 MT DTT DM80QF9 MA Blocker (channel blocker) DM80QF9 RN Direct blockade of both cloned rat rod photoreceptor cyclic nucleotide-gated non-selective cation (CNG) channel alpha-subunit and native CNG channels from Xenopus rod outer segments by H-8, a non-specific cyclic nucleotide-dependent protein kinase inhibitor. Neurosci Lett. 1997 Sep 12;233(1):37-40. DM80QF9 RU https://pubmed.ncbi.nlm.nih.gov/9324234 DM43ODJ DI DM43ODJ DM43ODJ DN H87/07 DM43ODJ MI TTMXGCW DM43ODJ MN Adrenergic receptor beta-3 (ADRB3) DM43ODJ MT DTT DM43ODJ MA Antagonist DM43ODJ RN LK 204-545, a highly selective beta1-adrenoceptor antagonist at human beta-adrenoceptors. Eur J Pharmacol. 1999 Feb 19;367(2-3):431-5. DM43ODJ RU https://pubmed.ncbi.nlm.nih.gov/10079020 DM4RVGO DI DM4RVGO DM4RVGO DN H-89 DM4RVGO MI TT5U49F DM4RVGO MN PRKACA messenger RNA (PRKACA mRNA) DM4RVGO MT DTT DM4RVGO MA Inhibitor DM4RVGO RN Inhibition of forskolin-induced neurite outgrowth and protein phosphorylation by a newly synthesized selective inhibitor of cyclic AMP-dependent protein kinase, N-[2-(p-bromocinnamylamino)ethyl]-5-isoquinolinesulfonamide (H-89), of PC12D pheochromocytoma cells. J Biol Chem. 1990 Mar 25;265(9):5267-72. DM4RVGO RU https://pubmed.ncbi.nlm.nih.gov/2156866 DM61G0I DI DM61G0I DM61G0I DN H-Aba-ala-Gly-Phe-leu-OH DM61G0I MI TT27RFC DM61G0I MN Opioid receptor delta (OPRD1) DM61G0I MT DTT DM61G0I MA Inhibitor DM61G0I RN Further studies of tyrosine surrogates in opioid receptor peptide ligands. Bioorg Med Chem Lett. 2007 May 1;17(9):2656-60. DM61G0I RU https://pubmed.ncbi.nlm.nih.gov/17350835 DM61G0I DI DM61G0I DM61G0I DN H-Aba-ala-Gly-Phe-leu-OH DM61G0I MI TTKWM86 DM61G0I MN Opioid receptor mu (MOP) DM61G0I MT DTT DM61G0I MA Inhibitor DM61G0I RN Further studies of tyrosine surrogates in opioid receptor peptide ligands. Bioorg Med Chem Lett. 2007 May 1;17(9):2656-60. DM61G0I RU https://pubmed.ncbi.nlm.nih.gov/17350835 DMKD94Q DI DMKD94Q DMKD94Q DN H-Aba-ala-Gly-Phe-Met-OH DMKD94Q MI TT27RFC DMKD94Q MN Opioid receptor delta (OPRD1) DMKD94Q MT DTT DMKD94Q MA Inhibitor DMKD94Q RN Further studies of tyrosine surrogates in opioid receptor peptide ligands. Bioorg Med Chem Lett. 2007 May 1;17(9):2656-60. DMKD94Q RU https://pubmed.ncbi.nlm.nih.gov/17350835 DMKD94Q DI DMKD94Q DMKD94Q DN H-Aba-ala-Gly-Phe-Met-OH DMKD94Q MI TTKWM86 DMKD94Q MN Opioid receptor mu (MOP) DMKD94Q MT DTT DMKD94Q MA Inhibitor DMKD94Q RN Further studies of tyrosine surrogates in opioid receptor peptide ligands. Bioorg Med Chem Lett. 2007 May 1;17(9):2656-60. DMKD94Q RU https://pubmed.ncbi.nlm.nih.gov/17350835 DMH1L3P DI DMH1L3P DMH1L3P DN H-Aba-Gly-Gly-Phe-Leu-OH DMH1L3P MI TT27RFC DMH1L3P MN Opioid receptor delta (OPRD1) DMH1L3P MT DTT DMH1L3P MA Inhibitor DMH1L3P RN Further studies of tyrosine surrogates in opioid receptor peptide ligands. Bioorg Med Chem Lett. 2007 May 1;17(9):2656-60. DMH1L3P RU https://pubmed.ncbi.nlm.nih.gov/17350835 DMH1L3P DI DMH1L3P DMH1L3P DN H-Aba-Gly-Gly-Phe-Leu-OH DMH1L3P MI TTKWM86 DMH1L3P MN Opioid receptor mu (MOP) DMH1L3P MT DTT DMH1L3P MA Inhibitor DMH1L3P RN Further studies of tyrosine surrogates in opioid receptor peptide ligands. Bioorg Med Chem Lett. 2007 May 1;17(9):2656-60. DMH1L3P RU https://pubmed.ncbi.nlm.nih.gov/17350835 DMFE3J4 DI DMFE3J4 DMFE3J4 DN H-Aba-ser-Gly-Phe-Leu-Thr-OH DMFE3J4 MI TT27RFC DMFE3J4 MN Opioid receptor delta (OPRD1) DMFE3J4 MT DTT DMFE3J4 MA Inhibitor DMFE3J4 RN Further studies of tyrosine surrogates in opioid receptor peptide ligands. Bioorg Med Chem Lett. 2007 May 1;17(9):2656-60. DMFE3J4 RU https://pubmed.ncbi.nlm.nih.gov/17350835 DMFE3J4 DI DMFE3J4 DMFE3J4 DN H-Aba-ser-Gly-Phe-Leu-Thr-OH DMFE3J4 MI TTKWM86 DMFE3J4 MN Opioid receptor mu (MOP) DMFE3J4 MT DTT DMFE3J4 MA Inhibitor DMFE3J4 RN Further studies of tyrosine surrogates in opioid receptor peptide ligands. Bioorg Med Chem Lett. 2007 May 1;17(9):2656-60. DMFE3J4 RU https://pubmed.ncbi.nlm.nih.gov/17350835 DMQCGRI DI DMQCGRI DMQCGRI DN HAEGTFTSDVSSYLEGQAAKEFIAWLVKGRG-NH2 DMQCGRI MI TTVIMDE DMQCGRI MN Glucagon-like peptide 1 receptor (GLP1R) DMQCGRI MT DTT DMQCGRI MA Inhibitor DMQCGRI RN Design and synthesis of conformationally constrained glucagon-like peptide-1 derivatives with increased plasma stability and prolonged in vivo acti... J Med Chem. 2008 May 8;51(9):2758-65. DMQCGRI RU https://pubmed.ncbi.nlm.nih.gov/18412318 DMN54LS DI DMN54LS DMN54LS DN HAEGTFTSDVSSYLEGQAAKEIFAWLVKGR DMN54LS MI TTVIMDE DMN54LS MN Glucagon-like peptide 1 receptor (GLP1R) DMN54LS MT DTT DMN54LS MA Inhibitor DMN54LS RN Search for alpha-helical propensity in the receptor-bound conformation of glucagon-like peptide-1. Bioorg Med Chem. 2008 Dec 1;16(23):10106-12. DMN54LS RU https://pubmed.ncbi.nlm.nih.gov/18952440 DMO6MGJ DI DMO6MGJ DMO6MGJ DN Haempatch DMO6MGJ MI TT6L509 DMO6MGJ MN Coagulation factor IIa (F2) DMO6MGJ MT DTT DMO6MGJ MA Inhibitor DMO6MGJ RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2362). DMO6MGJ RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2362 DM5S4AO DI DM5S4AO DM5S4AO DN H-Ala-Pro-Phe-Phe-NH2 DM5S4AO MI TTZPO1L DM5S4AO MN Substance-P receptor (TACR1) DM5S4AO MT DTT DM5S4AO MA Inhibitor DM5S4AO RN Discovery of dipeptides with high affinity to the specific binding site for substance P1-7. J Med Chem. 2010 Mar 25;53(6):2383-9. DM5S4AO RU https://pubmed.ncbi.nlm.nih.gov/20178322 DMJB87Q DI DMJB87Q DMJB87Q DN Halisulfate 1 DMJB87Q MI TTN9T81 DMJB87Q MN Arachidonate 15-lipoxygenase (15-LOX) DMJB87Q MT DTT DMJB87Q MA Inhibitor DMJB87Q RN Exploring sponge-derived terpenoids for their potency and selectivity against 12-human, 15-human, and 15-soybean lipoxygenases. J Nat Prod. 2003 Feb;66(2):230-5. DMJB87Q RU https://pubmed.ncbi.nlm.nih.gov/12608855 DMJB87Q DI DMJB87Q DMJB87Q DN Halisulfate 1 DMJB87Q MI TT58ZYW DMJB87Q MN Mycobacterium Isocitrate lyase (MycB icl) DMJB87Q MT DTT DMJB87Q MA Inhibitor DMJB87Q RN Sesterterpene sulfates as isocitrate lyase inhibitors from tropical sponge Hippospongia sp. Bioorg Med Chem Lett. 2007 May 1;17(9):2483-6. DMJB87Q RU https://pubmed.ncbi.nlm.nih.gov/17317180 DMF6V8W DI DMF6V8W DMF6V8W DN HALOPEMIDE DMF6V8W MI TTQW170 DMF6V8W MN Phospholipase D (PLD) DMF6V8W MT DTT DMF6V8W MA Inhibitor DMF6V8W RN Design of isoform-selective phospholipase D inhibitors that modulate cancer cell invasiveness. Nat Chem Biol. 2009 Feb;5(2):108-17. DMF6V8W RU https://pubmed.ncbi.nlm.nih.gov/19136975 DMF6V8W DI DMF6V8W DMF6V8W DN HALOPEMIDE DMF6V8W MI TT3T17P DMF6V8W MN Phospholipase D1 (PLD1) DMF6V8W MT DTT DMF6V8W MA Inhibitor DMF6V8W RN Design of isoform-selective phospholipase D inhibitors that modulate cancer cell invasiveness. Nat Chem Biol. 2009 Feb;5(2):108-17. DMF6V8W RU https://pubmed.ncbi.nlm.nih.gov/19136975 DMWCXPK DI DMWCXPK DMWCXPK DN Haloperidol DMWCXPK MI TTTPE1L DMWCXPK MN HUMAN opioid receptor sigma 1 (OPRS1) DMWCXPK MT DTT DMWCXPK MA Modulator DMWCXPK RN A SARS-CoV-2 protein interaction map reveals targets for drug repurposing DMWCXPK RU https://www.nature.com/articles/s41586-020-2286-9 DMWCXPK DI DMWCXPK DMWCXPK DN Haloperidol DMWCXPK MI TTIS0R2 DMWCXPK MN HUMAN sigma intracellular receptor 2 (TMEM97) DMWCXPK MT DTT DMWCXPK MA Modulator DMWCXPK RN A SARS-CoV-2 protein interaction map reveals targets for drug repurposing DMWCXPK RU https://www.nature.com/articles/s41586-020-2286-9 DM5SULN DI DM5SULN DM5SULN DN Haloxyfop DM5SULN MI TTYAWV0 DM5SULN MN Plasmodium Acetyl-CoA carboxylase 1 (Malaria ACC1) DM5SULN MT DTT DM5SULN MA Binder DM5SULN RN The apicoplast as an antimalarial drug target. Drug Resist Updat. 2001 Jun;4(3):145-51. DM5SULN RU https://pubmed.ncbi.nlm.nih.gov/11768328 DM4AEGQ DI DM4AEGQ DM4AEGQ DN HALOXYSTEROL A DM4AEGQ MI TT1RS9F DM4AEGQ MN Acetylcholinesterase (AChE) DM4AEGQ MT DTT DM4AEGQ MA Inhibitor DM4AEGQ RN Isolation and cholinesterase-inhibition studies of sterols from Haloxylon recurvum. Bioorg Med Chem Lett. 2006 Feb;16(3):573-80. DM4AEGQ RU https://pubmed.ncbi.nlm.nih.gov/16274989 DM4AEGQ DI DM4AEGQ DM4AEGQ DN HALOXYSTEROL A DM4AEGQ MI TTEB0GD DM4AEGQ MN Cholinesterase (BCHE) DM4AEGQ MT DTT DM4AEGQ MA Inhibitor DM4AEGQ RN Isolation and cholinesterase-inhibition studies of sterols from Haloxylon recurvum. Bioorg Med Chem Lett. 2006 Feb;16(3):573-80. DM4AEGQ RU https://pubmed.ncbi.nlm.nih.gov/16274989 DMD8O7S DI DMD8O7S DMD8O7S DN HALOXYSTEROL B DMD8O7S MI TT1RS9F DMD8O7S MN Acetylcholinesterase (AChE) DMD8O7S MT DTT DMD8O7S MA Inhibitor DMD8O7S RN Isolation and cholinesterase-inhibition studies of sterols from Haloxylon recurvum. Bioorg Med Chem Lett. 2006 Feb;16(3):573-80. DMD8O7S RU https://pubmed.ncbi.nlm.nih.gov/16274989 DMD8O7S DI DMD8O7S DMD8O7S DN HALOXYSTEROL B DMD8O7S MI TTEB0GD DMD8O7S MN Cholinesterase (BCHE) DMD8O7S MT DTT DMD8O7S MA Inhibitor DMD8O7S RN Isolation and cholinesterase-inhibition studies of sterols from Haloxylon recurvum. Bioorg Med Chem Lett. 2006 Feb;16(3):573-80. DMD8O7S RU https://pubmed.ncbi.nlm.nih.gov/16274989 DMU1DHM DI DMU1DHM DMU1DHM DN Haloxysterol C DMU1DHM MI TT1RS9F DMU1DHM MN Acetylcholinesterase (AChE) DMU1DHM MT DTT DMU1DHM MA Inhibitor DMU1DHM RN Isolation and cholinesterase-inhibition studies of sterols from Haloxylon recurvum. Bioorg Med Chem Lett. 2006 Feb;16(3):573-80. DMU1DHM RU https://pubmed.ncbi.nlm.nih.gov/16274989 DMU1DHM DI DMU1DHM DMU1DHM DN Haloxysterol C DMU1DHM MI TTEB0GD DMU1DHM MN Cholinesterase (BCHE) DMU1DHM MT DTT DMU1DHM MA Inhibitor DMU1DHM RN Isolation and cholinesterase-inhibition studies of sterols from Haloxylon recurvum. Bioorg Med Chem Lett. 2006 Feb;16(3):573-80. DMU1DHM RU https://pubmed.ncbi.nlm.nih.gov/16274989 DMWCZLT DI DMWCZLT DMWCZLT DN Haloxysterol D DMWCZLT MI TT1RS9F DMWCZLT MN Acetylcholinesterase (AChE) DMWCZLT MT DTT DMWCZLT MA Inhibitor DMWCZLT RN Isolation and cholinesterase-inhibition studies of sterols from Haloxylon recurvum. Bioorg Med Chem Lett. 2006 Feb;16(3):573-80. DMWCZLT RU https://pubmed.ncbi.nlm.nih.gov/16274989 DMWCZLT DI DMWCZLT DMWCZLT DN Haloxysterol D DMWCZLT MI TTEB0GD DMWCZLT MN Cholinesterase (BCHE) DMWCZLT MT DTT DMWCZLT MA Inhibitor DMWCZLT RN Isolation and cholinesterase-inhibition studies of sterols from Haloxylon recurvum. Bioorg Med Chem Lett. 2006 Feb;16(3):573-80. DMWCZLT RU https://pubmed.ncbi.nlm.nih.gov/16274989 DMJN0BL DI DMJN0BL DMJN0BL DN HAMI3379 DMJN0BL MI TT0PZR5 DMJN0BL MN Leukotriene CysLT2 receptor (CYSLTR2) DMJN0BL MT DTT DMJN0BL MA Antagonist DMJN0BL RN Pharmacological characterization of the first potent and selective antagonist at the cysteinyl leukotriene 2 (CysLT(2)) receptor. Br J Pharmacol. 2010 May;160(2):399-409. DMJN0BL RU https://pubmed.ncbi.nlm.nih.gov/20423349 DM5SUYP DI DM5SUYP DM5SUYP DN H-Apa-ala-Gly-Phe-leu-OH DM5SUYP MI TT27RFC DM5SUYP MN Opioid receptor delta (OPRD1) DM5SUYP MT DTT DM5SUYP MA Inhibitor DM5SUYP RN Further studies of tyrosine surrogates in opioid receptor peptide ligands. Bioorg Med Chem Lett. 2007 May 1;17(9):2656-60. DM5SUYP RU https://pubmed.ncbi.nlm.nih.gov/17350835 DM5SUYP DI DM5SUYP DM5SUYP DN H-Apa-ala-Gly-Phe-leu-OH DM5SUYP MI TTKWM86 DM5SUYP MN Opioid receptor mu (MOP) DM5SUYP MT DTT DM5SUYP MA Inhibitor DM5SUYP RN Further studies of tyrosine surrogates in opioid receptor peptide ligands. Bioorg Med Chem Lett. 2007 May 1;17(9):2656-60. DM5SUYP RU https://pubmed.ncbi.nlm.nih.gov/17350835 DM9K6H5 DI DM9K6H5 DM9K6H5 DN HAp-IFN DM9K6H5 MI TTSIUJ9 DM9K6H5 MN Interferon-alpha 2 (IFNA2) DM9K6H5 MT DTT DM9K6H5 MA Modulator DM9K6H5 RN CN patent application no. 1921880, Protein drug sustained-release microparticle preparation for injection and process for producing the same. DM9K6H5 RU http://www.google.com/patents/CN1921880A?cl=en DMENVKA DI DMENVKA DMENVKA DN H-Arg-Arg-Pro-Tyr-Ile-Aac-OH DMENVKA MI TTTUMEP DMENVKA MN Neurotensin receptor type 1 (NTSR1) DMENVKA MT DTT DMENVKA MA Inhibitor DMENVKA RN Novel insights into GPCR-peptide interactions: mutations in extracellular loop 1, ligand backbone methylations and molecular modeling of neurotensi... Bioorg Med Chem. 2008 Oct 15;16(20):9359-68. DMENVKA RU https://pubmed.ncbi.nlm.nih.gov/18809332 DM4FKR1 DI DM4FKR1 DM4FKR1 DN H-Arg-Arg-Pro-Tyr-Ile-N-Me-Leu-OH DM4FKR1 MI TTTUMEP DM4FKR1 MN Neurotensin receptor type 1 (NTSR1) DM4FKR1 MT DTT DM4FKR1 MA Inhibitor DM4FKR1 RN Novel insights into GPCR-peptide interactions: mutations in extracellular loop 1, ligand backbone methylations and molecular modeling of neurotensi... Bioorg Med Chem. 2008 Oct 15;16(20):9359-68. DM4FKR1 RU https://pubmed.ncbi.nlm.nih.gov/18809332 DM107RT DI DM107RT DM107RT DN H-Arg-Arg-Pro-Tyr-N-Me-Ile-Leu-OH DM107RT MI TTTUMEP DM107RT MN Neurotensin receptor type 1 (NTSR1) DM107RT MT DTT DM107RT MA Inhibitor DM107RT RN Novel insights into GPCR-peptide interactions: mutations in extracellular loop 1, ligand backbone methylations and molecular modeling of neurotensi... Bioorg Med Chem. 2008 Oct 15;16(20):9359-68. DM107RT RU https://pubmed.ncbi.nlm.nih.gov/18809332 DMSXLKJ DI DMSXLKJ DMSXLKJ DN H-Arg-N-Me-Arg-Pro-Tyr-Ile-Leu-OH DMSXLKJ MI TTTUMEP DMSXLKJ MN Neurotensin receptor type 1 (NTSR1) DMSXLKJ MT DTT DMSXLKJ MA Inhibitor DMSXLKJ RN Novel insights into GPCR-peptide interactions: mutations in extracellular loop 1, ligand backbone methylations and molecular modeling of neurotensi... Bioorg Med Chem. 2008 Oct 15;16(20):9359-68. DMSXLKJ RU https://pubmed.ncbi.nlm.nih.gov/18809332 DMJ6N1X DI DMJ6N1X DMJ6N1X DN H-Arg-Pro-Lys-Pro-Gln-Gln-Phe-OH DMJ6N1X MI TTZPO1L DMJ6N1X MN Substance-P receptor (TACR1) DMJ6N1X MT DTT DMJ6N1X MA Inhibitor DMJ6N1X RN Discovery of dipeptides with high affinity to the specific binding site for substance P1-7. J Med Chem. 2010 Mar 25;53(6):2383-9. DMJ6N1X RU https://pubmed.ncbi.nlm.nih.gov/20178322 DM5VDU2 DI DM5VDU2 DM5VDU2 DN HBN-2 DM5VDU2 MI TTTUMEP DM5VDU2 MN Neurotensin receptor type 1 (NTSR1) DM5VDU2 MT DTT DM5VDU2 MA Modulator DM5VDU2 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 309). DM5VDU2 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=309 DMKDBFL DI DMKDBFL DMKDBFL DN HBR-985 DMKDBFL MI TTP835K DMKDBFL MN ATP-binding cassette transporter C8 (ABCC8) DMKDBFL MT DTT DMKDBFL MA Inhibitor DMKDBFL RN Cardioselective K(ATP) channel blockers derived from a new series of m-anisamidoethylbenzenesulfonylthioureas. J Med Chem. 2001 Mar 29;44(7):1085-98. DMKDBFL RU https://pubmed.ncbi.nlm.nih.gov/11297455 DMKDBFL DI DMKDBFL DMKDBFL DN HBR-985 DMKDBFL MI TT329V4 DMKDBFL MN Inward rectifier potassium channel Kir6.2 (KCNJ11) DMKDBFL MT DTT DMKDBFL MA Inhibitor DMKDBFL RN Cardioselective K(ATP) channel blockers derived from a new series of m-anisamidoethylbenzenesulfonylthioureas. J Med Chem. 2001 Mar 29;44(7):1085-98. DMKDBFL RU https://pubmed.ncbi.nlm.nih.gov/11297455 DMCQH23 DI DMCQH23 DMCQH23 DN H-c[Cys-Phe-DTrp-Lys-Thr-Cys]-OH DMCQH23 MI TTZ6T9E DMCQH23 MN Somatostatin receptor type 2 (SSTR2) DMCQH23 MT DTT DMCQH23 MA Inhibitor DMCQH23 RN Novel sst2-selective somatostatin agonists. Three-dimensional consensus structure by NMR. J Med Chem. 2006 Jul 27;49(15):4487-96. DMCQH23 RU https://pubmed.ncbi.nlm.nih.gov/16854054 DMOY2AI DI DMOY2AI DMOY2AI DN HC-030031 DMOY2AI MI TT79AOF DMOY2AI MN Transient receptor potential channel (TRP channel) DMOY2AI MT DTT DMOY2AI MA Inhibitor DMOY2AI RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4211). DMOY2AI RU http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=4211 DMOG1Q4 DI DMOG1Q4 DMOG1Q4 DN HC-056456 DMOG1Q4 MI TT5CISB DMOG1Q4 MN Cation channel sperm-associated protein 1 (CatSper1) DMOG1Q4 MT DTT DMOG1Q4 MA Blocker (channel blocker) DMOG1Q4 RN Pharmacological targeting of native CatSper channels reveals a required role in maintenance of sperm hyperactivation. PLoS One. 2009 Aug 31;4(8):e6844. DMOG1Q4 RU https://pubmed.ncbi.nlm.nih.gov/19718436 DMIXY1O DI DMIXY1O DMIXY1O DN HC067047 DMIXY1O MI TTKP2SU DMIXY1O MN Transient receptor potential cation channel V4 (TRPV4) DMIXY1O MT DTT DMIXY1O MA Blocker (channel blocker) DMIXY1O RN Inhibition of the cation channel TRPV4 improves bladder function in mice and rats with cyclophosphamide-induced cystitis. Proc Natl Acad Sci U S A. 2010 Nov 2;107(44):19084-9. DMIXY1O RU https://pubmed.ncbi.nlm.nih.gov/20956320 DM1BLCX DI DM1BLCX DM1BLCX DN HC3-1496 DM1BLCX MI TT8D13I DM1BLCX MN Complement factor D (CFD) DM1BLCX MT DTT DM1BLCX MA Modulator DM1BLCX RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2842). DM1BLCX RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2842 DMV751G DI DMV751G DMV751G DN H-Cdp-ala-Gly-Phe-leu-OH DMV751G MI TT27RFC DMV751G MN Opioid receptor delta (OPRD1) DMV751G MT DTT DMV751G MA Inhibitor DMV751G RN Further studies of tyrosine surrogates in opioid receptor peptide ligands. Bioorg Med Chem Lett. 2007 May 1;17(9):2656-60. DMV751G RU https://pubmed.ncbi.nlm.nih.gov/17350835 DMV751G DI DMV751G DMV751G DN H-Cdp-ala-Gly-Phe-leu-OH DMV751G MI TTQW87Y DMV751G MN Opioid receptor kappa (OPRK1) DMV751G MT DTT DMV751G MA Inhibitor DMV751G RN Further studies of tyrosine surrogates in opioid receptor peptide ligands. Bioorg Med Chem Lett. 2007 May 1;17(9):2656-60. DMV751G RU https://pubmed.ncbi.nlm.nih.gov/17350835 DMV751G DI DMV751G DMV751G DN H-Cdp-ala-Gly-Phe-leu-OH DMV751G MI TTKWM86 DMV751G MN Opioid receptor mu (MOP) DMV751G MT DTT DMV751G MA Inhibitor DMV751G RN Further studies of tyrosine surrogates in opioid receptor peptide ligands. Bioorg Med Chem Lett. 2007 May 1;17(9):2656-60. DMV751G RU https://pubmed.ncbi.nlm.nih.gov/17350835 DMVEB8C DI DMVEB8C DMVEB8C DN H-Cdp-Gly-Gly-Phe-Leu-OH DMVEB8C MI TT27RFC DMVEB8C MN Opioid receptor delta (OPRD1) DMVEB8C MT DTT DMVEB8C MA Inhibitor DMVEB8C RN Further studies of tyrosine surrogates in opioid receptor peptide ligands. Bioorg Med Chem Lett. 2007 May 1;17(9):2656-60. DMVEB8C RU https://pubmed.ncbi.nlm.nih.gov/17350835 DMVEB8C DI DMVEB8C DMVEB8C DN H-Cdp-Gly-Gly-Phe-Leu-OH DMVEB8C MI TTQW87Y DMVEB8C MN Opioid receptor kappa (OPRK1) DMVEB8C MT DTT DMVEB8C MA Inhibitor DMVEB8C RN Further studies of tyrosine surrogates in opioid receptor peptide ligands. Bioorg Med Chem Lett. 2007 May 1;17(9):2656-60. DMVEB8C RU https://pubmed.ncbi.nlm.nih.gov/17350835 DMVEB8C DI DMVEB8C DMVEB8C DN H-Cdp-Gly-Gly-Phe-Leu-OH DMVEB8C MI TTKWM86 DMVEB8C MN Opioid receptor mu (MOP) DMVEB8C MT DTT DMVEB8C MA Inhibitor DMVEB8C RN Further studies of tyrosine surrogates in opioid receptor peptide ligands. Bioorg Med Chem Lett. 2007 May 1;17(9):2656-60. DMVEB8C RU https://pubmed.ncbi.nlm.nih.gov/17350835 DMCDLTV DI DMCDLTV DMCDLTV DN H-Cdp-ser-Gly-Phe-Leu-Thr-OH DMCDLTV MI TT27RFC DMCDLTV MN Opioid receptor delta (OPRD1) DMCDLTV MT DTT DMCDLTV MA Inhibitor DMCDLTV RN Further studies of tyrosine surrogates in opioid receptor peptide ligands. Bioorg Med Chem Lett. 2007 May 1;17(9):2656-60. DMCDLTV RU https://pubmed.ncbi.nlm.nih.gov/17350835 DMCDLTV DI DMCDLTV DMCDLTV DN H-Cdp-ser-Gly-Phe-Leu-Thr-OH DMCDLTV MI TTKWM86 DMCDLTV MN Opioid receptor mu (MOP) DMCDLTV MT DTT DMCDLTV MA Inhibitor DMCDLTV RN Further studies of tyrosine surrogates in opioid receptor peptide ligands. Bioorg Med Chem Lett. 2007 May 1;17(9):2656-60. DMCDLTV RU https://pubmed.ncbi.nlm.nih.gov/17350835 DM415ZX DI DM415ZX DM415ZX DN HCGRPalpha DM415ZX MI TTY6O0Q DM415ZX MN Calcitonin gene-related peptide receptor (CGRPR) DM415ZX MT DTT DM415ZX MA Inhibitor DM415ZX RN cis-4-(Piperazin-1-yl)-5,6,7a,8,9,10,11,11a-octahydrobenzofuro[2,3-h]quinazolin-2-amine (A-987306), a new histamine H4R antagonist that blocks pain... J Med Chem. 2008 Nov 27;51(22):7094-8. DM415ZX RU https://pubmed.ncbi.nlm.nih.gov/18983139 DM3V4XG DI DM3V4XG DM3V4XG DN H-Cpa-c[pen-Gly-Phe-pen]OH DM3V4XG MI TT27RFC DM3V4XG MN Opioid receptor delta (OPRD1) DM3V4XG MT DTT DM3V4XG MA Inhibitor DM3V4XG RN Further studies of tyrosine surrogates in opioid receptor peptide ligands. Bioorg Med Chem Lett. 2007 May 1;17(9):2656-60. DM3V4XG RU https://pubmed.ncbi.nlm.nih.gov/17350835 DMU6PV8 DI DMU6PV8 DMU6PV8 DN H-Cpa-Gly-Gly-Phe-Met-NH2 DMU6PV8 MI TT27RFC DMU6PV8 MN Opioid receptor delta (OPRD1) DMU6PV8 MT DTT DMU6PV8 MA Inhibitor DMU6PV8 RN Further studies of tyrosine surrogates in opioid receptor peptide ligands. Bioorg Med Chem Lett. 2007 May 1;17(9):2656-60. DMU6PV8 RU https://pubmed.ncbi.nlm.nih.gov/17350835 DMU6PV8 DI DMU6PV8 DMU6PV8 DN H-Cpa-Gly-Gly-Phe-Met-NH2 DMU6PV8 MI TTQW87Y DMU6PV8 MN Opioid receptor kappa (OPRK1) DMU6PV8 MT DTT DMU6PV8 MA Inhibitor DMU6PV8 RN Further studies of tyrosine surrogates in opioid receptor peptide ligands. Bioorg Med Chem Lett. 2007 May 1;17(9):2656-60. DMU6PV8 RU https://pubmed.ncbi.nlm.nih.gov/17350835 DMU6PV8 DI DMU6PV8 DMU6PV8 DN H-Cpa-Gly-Gly-Phe-Met-NH2 DMU6PV8 MI TTKWM86 DMU6PV8 MN Opioid receptor mu (MOP) DMU6PV8 MT DTT DMU6PV8 MA Inhibitor DMU6PV8 RN Further studies of tyrosine surrogates in opioid receptor peptide ligands. Bioorg Med Chem Lett. 2007 May 1;17(9):2656-60. DMU6PV8 RU https://pubmed.ncbi.nlm.nih.gov/17350835 DM154G2 DI DM154G2 DM154G2 DN H-Cpa-Gly-Gly-Phe-Met-OH DM154G2 MI TT27RFC DM154G2 MN Opioid receptor delta (OPRD1) DM154G2 MT DTT DM154G2 MA Inhibitor DM154G2 RN Further studies of tyrosine surrogates in opioid receptor peptide ligands. Bioorg Med Chem Lett. 2007 May 1;17(9):2656-60. DM154G2 RU https://pubmed.ncbi.nlm.nih.gov/17350835 DM154G2 DI DM154G2 DM154G2 DN H-Cpa-Gly-Gly-Phe-Met-OH DM154G2 MI TTQW87Y DM154G2 MN Opioid receptor kappa (OPRK1) DM154G2 MT DTT DM154G2 MA Inhibitor DM154G2 RN Further studies of tyrosine surrogates in opioid receptor peptide ligands. Bioorg Med Chem Lett. 2007 May 1;17(9):2656-60. DM154G2 RU https://pubmed.ncbi.nlm.nih.gov/17350835 DM154G2 DI DM154G2 DM154G2 DN H-Cpa-Gly-Gly-Phe-Met-OH DM154G2 MI TTKWM86 DM154G2 MN Opioid receptor mu (MOP) DM154G2 MT DTT DM154G2 MA Inhibitor DM154G2 RN Further studies of tyrosine surrogates in opioid receptor peptide ligands. Bioorg Med Chem Lett. 2007 May 1;17(9):2656-60. DM154G2 RU https://pubmed.ncbi.nlm.nih.gov/17350835 DMPL0BR DI DMPL0BR DMPL0BR DN H-Cxp-ala-Gly-Phe-leu-OH DMPL0BR MI TT27RFC DMPL0BR MN Opioid receptor delta (OPRD1) DMPL0BR MT DTT DMPL0BR MA Inhibitor DMPL0BR RN Further studies of tyrosine surrogates in opioid receptor peptide ligands. Bioorg Med Chem Lett. 2007 May 1;17(9):2656-60. DMPL0BR RU https://pubmed.ncbi.nlm.nih.gov/17350835 DM6839G DI DM6839G DM6839G DN H-DArg-Arg-Pro-Hyp-Gly-Igl-Ser-D-BT-OH(JMV1638) DM6839G MI TTG5QIA DM6839G MN B1 bradykinin receptor (BDKRB1) DM6839G MT DTT DM6839G MA Inhibitor DM6839G RN Synthesis and biological evaluation of bradykinin B(1)/B(2) and selective B(1) receptor antagonists. J Med Chem. 2000 Jun 15;43(12):2382-6. DM6839G RU https://pubmed.ncbi.nlm.nih.gov/10882364 DM6839G DI DM6839G DM6839G DN H-DArg-Arg-Pro-Hyp-Gly-Igl-Ser-D-BT-OH(JMV1638) DM6839G MI TTGY8IW DM6839G MN B2 bradykinin receptor (BDKRB2) DM6839G MT DTT DM6839G MA Inhibitor DM6839G RN Synthesis and biological evaluation of bradykinin B(1)/B(2) and selective B(1) receptor antagonists. J Med Chem. 2000 Jun 15;43(12):2382-6. DM6839G RU https://pubmed.ncbi.nlm.nih.gov/10882364 DM9WJZK DI DM9WJZK DM9WJZK DN H-Dmt-Aba-Gly-NH-CH2-Bid DM9WJZK MI TT27RFC DM9WJZK MN Opioid receptor delta (OPRD1) DM9WJZK MT DTT DM9WJZK MA Inhibitor DM9WJZK RN New 2',6'-dimethyl-L-tyrosine (Dmt) opioid peptidomimetics based on the Aba-Gly scaffold. Development of unique mu-opioid receptor ligands. J Med Chem. 2006 Jun 29;49(13):3990-3. DM9WJZK RU https://pubmed.ncbi.nlm.nih.gov/16789756 DM9WJZK DI DM9WJZK DM9WJZK DN H-Dmt-Aba-Gly-NH-CH2-Bid DM9WJZK MI TTKWM86 DM9WJZK MN Opioid receptor mu (MOP) DM9WJZK MT DTT DM9WJZK MA Inhibitor DM9WJZK RN New 2',6'-dimethyl-L-tyrosine (Dmt) opioid peptidomimetics based on the Aba-Gly scaffold. Development of unique mu-opioid receptor ligands. J Med Chem. 2006 Jun 29;49(13):3990-3. DM9WJZK RU https://pubmed.ncbi.nlm.nih.gov/16789756 DM61CMS DI DM61CMS DM61CMS DN H-Dmt-Aba-Gly-NH-CH2-Ph DM61CMS MI TT27RFC DM61CMS MN Opioid receptor delta (OPRD1) DM61CMS MT DTT DM61CMS MA Inhibitor DM61CMS RN New 2',6'-dimethyl-L-tyrosine (Dmt) opioid peptidomimetics based on the Aba-Gly scaffold. Development of unique mu-opioid receptor ligands. J Med Chem. 2006 Jun 29;49(13):3990-3. DM61CMS RU https://pubmed.ncbi.nlm.nih.gov/16789756 DM61CMS DI DM61CMS DM61CMS DN H-Dmt-Aba-Gly-NH-CH2-Ph DM61CMS MI TTKWM86 DM61CMS MN Opioid receptor mu (MOP) DM61CMS MT DTT DM61CMS MA Inhibitor DM61CMS RN New 2',6'-dimethyl-L-tyrosine (Dmt) opioid peptidomimetics based on the Aba-Gly scaffold. Development of unique mu-opioid receptor ligands. J Med Chem. 2006 Jun 29;49(13):3990-3. DM61CMS RU https://pubmed.ncbi.nlm.nih.gov/16789756 DMCQYIJ DI DMCQYIJ DMCQYIJ DN H-Dmt-Aba-Gly-NH-Ph DMCQYIJ MI TT27RFC DMCQYIJ MN Opioid receptor delta (OPRD1) DMCQYIJ MT DTT DMCQYIJ MA Inhibitor DMCQYIJ RN New 2',6'-dimethyl-L-tyrosine (Dmt) opioid peptidomimetics based on the Aba-Gly scaffold. Development of unique mu-opioid receptor ligands. J Med Chem. 2006 Jun 29;49(13):3990-3. DMCQYIJ RU https://pubmed.ncbi.nlm.nih.gov/16789756 DMCQYIJ DI DMCQYIJ DMCQYIJ DN H-Dmt-Aba-Gly-NH-Ph DMCQYIJ MI TTKWM86 DMCQYIJ MN Opioid receptor mu (MOP) DMCQYIJ MT DTT DMCQYIJ MA Inhibitor DMCQYIJ RN New 2',6'-dimethyl-L-tyrosine (Dmt) opioid peptidomimetics based on the Aba-Gly scaffold. Development of unique mu-opioid receptor ligands. J Med Chem. 2006 Jun 29;49(13):3990-3. DMCQYIJ RU https://pubmed.ncbi.nlm.nih.gov/16789756 DMHK70B DI DMHK70B DMHK70B DN H-Dmt-D-Arg(NO2)-Phe-Lys(Z)-NH2 DMHK70B MI TT27RFC DMHK70B MN Opioid receptor delta (OPRD1) DMHK70B MT DTT DMHK70B MA Inhibitor DMHK70B RN From the potent and selective mu opioid receptor agonist H-Dmt-d-Arg-Phe-Lys-NH(2) to the potent delta antagonist H-Dmt-Tic-Phe-Lys(Z)-OH. J Med Chem. 2005 Aug 25;48(17):5608-11. DMHK70B RU https://pubmed.ncbi.nlm.nih.gov/16107162 DMHK70B DI DMHK70B DMHK70B DN H-Dmt-D-Arg(NO2)-Phe-Lys(Z)-NH2 DMHK70B MI TTKWM86 DMHK70B MN Opioid receptor mu (MOP) DMHK70B MT DTT DMHK70B MA Inhibitor DMHK70B RN From the potent and selective mu opioid receptor agonist H-Dmt-d-Arg-Phe-Lys-NH(2) to the potent delta antagonist H-Dmt-Tic-Phe-Lys(Z)-OH. J Med Chem. 2005 Aug 25;48(17):5608-11. DMHK70B RU https://pubmed.ncbi.nlm.nih.gov/16107162 DMM9EPQ DI DMM9EPQ DMM9EPQ DN H-Dmt-D-Arg(NO2)-Phe-Lys(Z)-OH DMM9EPQ MI TT27RFC DMM9EPQ MN Opioid receptor delta (OPRD1) DMM9EPQ MT DTT DMM9EPQ MA Inhibitor DMM9EPQ RN From the potent and selective mu opioid receptor agonist H-Dmt-d-Arg-Phe-Lys-NH(2) to the potent delta antagonist H-Dmt-Tic-Phe-Lys(Z)-OH. J Med Chem. 2005 Aug 25;48(17):5608-11. DMM9EPQ RU https://pubmed.ncbi.nlm.nih.gov/16107162 DMM9EPQ DI DMM9EPQ DMM9EPQ DN H-Dmt-D-Arg(NO2)-Phe-Lys(Z)-OH DMM9EPQ MI TTKWM86 DMM9EPQ MN Opioid receptor mu (MOP) DMM9EPQ MT DTT DMM9EPQ MA Inhibitor DMM9EPQ RN From the potent and selective mu opioid receptor agonist H-Dmt-d-Arg-Phe-Lys-NH(2) to the potent delta antagonist H-Dmt-Tic-Phe-Lys(Z)-OH. J Med Chem. 2005 Aug 25;48(17):5608-11. DMM9EPQ RU https://pubmed.ncbi.nlm.nih.gov/16107162 DM1ZDJ6 DI DM1ZDJ6 DM1ZDJ6 DN H-Dmt-Tic-(2R,3R)-beta-MeCha-Phe-NH2 DM1ZDJ6 MI TT27RFC DM1ZDJ6 MN Opioid receptor delta (OPRD1) DM1ZDJ6 MT DTT DM1ZDJ6 MA Inhibitor DM1ZDJ6 RN Beta-methyl substitution of cyclohexylalanine in Dmt-Tic-Cha-Phe peptides results in highly potent delta opioid antagonists. J Med Chem. 2007 Jan 25;50(2):328-33. DM1ZDJ6 RU https://pubmed.ncbi.nlm.nih.gov/17228874 DM1ZDJ6 DI DM1ZDJ6 DM1ZDJ6 DN H-Dmt-Tic-(2R,3R)-beta-MeCha-Phe-NH2 DM1ZDJ6 MI TTKWM86 DM1ZDJ6 MN Opioid receptor mu (MOP) DM1ZDJ6 MT DTT DM1ZDJ6 MA Inhibitor DM1ZDJ6 RN Beta-methyl substitution of cyclohexylalanine in Dmt-Tic-Cha-Phe peptides results in highly potent delta opioid antagonists. J Med Chem. 2007 Jan 25;50(2):328-33. DM1ZDJ6 RU https://pubmed.ncbi.nlm.nih.gov/17228874 DMC3APN DI DMC3APN DMC3APN DN H-Dmt-Tic-(2R,3R)-beta-MeCha-Phe-OH DMC3APN MI TT27RFC DMC3APN MN Opioid receptor delta (OPRD1) DMC3APN MT DTT DMC3APN MA Inhibitor DMC3APN RN Beta-methyl substitution of cyclohexylalanine in Dmt-Tic-Cha-Phe peptides results in highly potent delta opioid antagonists. J Med Chem. 2007 Jan 25;50(2):328-33. DMC3APN RU https://pubmed.ncbi.nlm.nih.gov/17228874 DMC3APN DI DMC3APN DMC3APN DN H-Dmt-Tic-(2R,3R)-beta-MeCha-Phe-OH DMC3APN MI TTKWM86 DMC3APN MN Opioid receptor mu (MOP) DMC3APN MT DTT DMC3APN MA Inhibitor DMC3APN RN Beta-methyl substitution of cyclohexylalanine in Dmt-Tic-Cha-Phe peptides results in highly potent delta opioid antagonists. J Med Chem. 2007 Jan 25;50(2):328-33. DMC3APN RU https://pubmed.ncbi.nlm.nih.gov/17228874 DMY97TN DI DMY97TN DMY97TN DN H-Dmt-Tic-(2R,3S)-beta-MeCha-Phe-NH2 DMY97TN MI TT27RFC DMY97TN MN Opioid receptor delta (OPRD1) DMY97TN MT DTT DMY97TN MA Inhibitor DMY97TN RN Beta-methyl substitution of cyclohexylalanine in Dmt-Tic-Cha-Phe peptides results in highly potent delta opioid antagonists. J Med Chem. 2007 Jan 25;50(2):328-33. DMY97TN RU https://pubmed.ncbi.nlm.nih.gov/17228874 DMY97TN DI DMY97TN DMY97TN DN H-Dmt-Tic-(2R,3S)-beta-MeCha-Phe-NH2 DMY97TN MI TTKWM86 DMY97TN MN Opioid receptor mu (MOP) DMY97TN MT DTT DMY97TN MA Inhibitor DMY97TN RN Beta-methyl substitution of cyclohexylalanine in Dmt-Tic-Cha-Phe peptides results in highly potent delta opioid antagonists. J Med Chem. 2007 Jan 25;50(2):328-33. DMY97TN RU https://pubmed.ncbi.nlm.nih.gov/17228874 DMGPAM0 DI DMGPAM0 DMGPAM0 DN H-Dmt-Tic-(2R,3S)-beta-MeCha-Phe-OH DMGPAM0 MI TT27RFC DMGPAM0 MN Opioid receptor delta (OPRD1) DMGPAM0 MT DTT DMGPAM0 MA Inhibitor DMGPAM0 RN Beta-methyl substitution of cyclohexylalanine in Dmt-Tic-Cha-Phe peptides results in highly potent delta opioid antagonists. J Med Chem. 2007 Jan 25;50(2):328-33. DMGPAM0 RU https://pubmed.ncbi.nlm.nih.gov/17228874 DMGPAM0 DI DMGPAM0 DMGPAM0 DN H-Dmt-Tic-(2R,3S)-beta-MeCha-Phe-OH DMGPAM0 MI TTKWM86 DMGPAM0 MN Opioid receptor mu (MOP) DMGPAM0 MT DTT DMGPAM0 MA Inhibitor DMGPAM0 RN Beta-methyl substitution of cyclohexylalanine in Dmt-Tic-Cha-Phe peptides results in highly potent delta opioid antagonists. J Med Chem. 2007 Jan 25;50(2):328-33. DMGPAM0 RU https://pubmed.ncbi.nlm.nih.gov/17228874 DMOI1U5 DI DMOI1U5 DMOI1U5 DN H-Dmt-Tic-(2S,3R)-beta-MeCha-Phe-NH2 DMOI1U5 MI TT27RFC DMOI1U5 MN Opioid receptor delta (OPRD1) DMOI1U5 MT DTT DMOI1U5 MA Inhibitor DMOI1U5 RN Beta-methyl substitution of cyclohexylalanine in Dmt-Tic-Cha-Phe peptides results in highly potent delta opioid antagonists. J Med Chem. 2007 Jan 25;50(2):328-33. DMOI1U5 RU https://pubmed.ncbi.nlm.nih.gov/17228874 DMOI1U5 DI DMOI1U5 DMOI1U5 DN H-Dmt-Tic-(2S,3R)-beta-MeCha-Phe-NH2 DMOI1U5 MI TTKWM86 DMOI1U5 MN Opioid receptor mu (MOP) DMOI1U5 MT DTT DMOI1U5 MA Inhibitor DMOI1U5 RN Beta-methyl substitution of cyclohexylalanine in Dmt-Tic-Cha-Phe peptides results in highly potent delta opioid antagonists. J Med Chem. 2007 Jan 25;50(2):328-33. DMOI1U5 RU https://pubmed.ncbi.nlm.nih.gov/17228874 DMZBFJ5 DI DMZBFJ5 DMZBFJ5 DN H-Dmt-Tic-(2S,3R)-beta-MeCha-Phe-OH DMZBFJ5 MI TT27RFC DMZBFJ5 MN Opioid receptor delta (OPRD1) DMZBFJ5 MT DTT DMZBFJ5 MA Inhibitor DMZBFJ5 RN Beta-methyl substitution of cyclohexylalanine in Dmt-Tic-Cha-Phe peptides results in highly potent delta opioid antagonists. J Med Chem. 2007 Jan 25;50(2):328-33. DMZBFJ5 RU https://pubmed.ncbi.nlm.nih.gov/17228874 DMZBFJ5 DI DMZBFJ5 DMZBFJ5 DN H-Dmt-Tic-(2S,3R)-beta-MeCha-Phe-OH DMZBFJ5 MI TTKWM86 DMZBFJ5 MN Opioid receptor mu (MOP) DMZBFJ5 MT DTT DMZBFJ5 MA Inhibitor DMZBFJ5 RN Beta-methyl substitution of cyclohexylalanine in Dmt-Tic-Cha-Phe peptides results in highly potent delta opioid antagonists. J Med Chem. 2007 Jan 25;50(2):328-33. DMZBFJ5 RU https://pubmed.ncbi.nlm.nih.gov/17228874 DMNS1GX DI DMNS1GX DMNS1GX DN H-Dmt-Tic-(2S,3S)-beta-MeCha-Phe-NH2 DMNS1GX MI TT27RFC DMNS1GX MN Opioid receptor delta (OPRD1) DMNS1GX MT DTT DMNS1GX MA Inhibitor DMNS1GX RN Beta-methyl substitution of cyclohexylalanine in Dmt-Tic-Cha-Phe peptides results in highly potent delta opioid antagonists. J Med Chem. 2007 Jan 25;50(2):328-33. DMNS1GX RU https://pubmed.ncbi.nlm.nih.gov/17228874 DMNS1GX DI DMNS1GX DMNS1GX DN H-Dmt-Tic-(2S,3S)-beta-MeCha-Phe-NH2 DMNS1GX MI TTKWM86 DMNS1GX MN Opioid receptor mu (MOP) DMNS1GX MT DTT DMNS1GX MA Inhibitor DMNS1GX RN Beta-methyl substitution of cyclohexylalanine in Dmt-Tic-Cha-Phe peptides results in highly potent delta opioid antagonists. J Med Chem. 2007 Jan 25;50(2):328-33. DMNS1GX RU https://pubmed.ncbi.nlm.nih.gov/17228874 DMM9TUR DI DMM9TUR DMM9TUR DN H-Dmt-Tic-(2S,3S)-beta-MeCha-Phe-OH DMM9TUR MI TT27RFC DMM9TUR MN Opioid receptor delta (OPRD1) DMM9TUR MT DTT DMM9TUR MA Inhibitor DMM9TUR RN Beta-methyl substitution of cyclohexylalanine in Dmt-Tic-Cha-Phe peptides results in highly potent delta opioid antagonists. J Med Chem. 2007 Jan 25;50(2):328-33. DMM9TUR RU https://pubmed.ncbi.nlm.nih.gov/17228874 DMM9TUR DI DMM9TUR DMM9TUR DN H-Dmt-Tic-(2S,3S)-beta-MeCha-Phe-OH DMM9TUR MI TTKWM86 DMM9TUR MN Opioid receptor mu (MOP) DMM9TUR MT DTT DMM9TUR MA Inhibitor DMM9TUR RN Beta-methyl substitution of cyclohexylalanine in Dmt-Tic-Cha-Phe peptides results in highly potent delta opioid antagonists. J Med Chem. 2007 Jan 25;50(2):328-33. DMM9TUR RU https://pubmed.ncbi.nlm.nih.gov/17228874 DM4JP8L DI DM4JP8L DM4JP8L DN H-Dmt-Tic-Asp-N(Me)-Ph DM4JP8L MI TT27RFC DM4JP8L MN Opioid receptor delta (OPRD1) DM4JP8L MT DTT DM4JP8L MA Inhibitor DM4JP8L RN Further studies on lead compounds containing the opioid pharmacophore Dmt-Tic. J Med Chem. 2008 Aug 28;51(16):5109-17. DM4JP8L RU https://pubmed.ncbi.nlm.nih.gov/18680274 DM4JP8L DI DM4JP8L DM4JP8L DN H-Dmt-Tic-Asp-N(Me)-Ph DM4JP8L MI TTKWM86 DM4JP8L MN Opioid receptor mu (MOP) DM4JP8L MT DTT DM4JP8L MA Inhibitor DM4JP8L RN Further studies on lead compounds containing the opioid pharmacophore Dmt-Tic. J Med Chem. 2008 Aug 28;51(16):5109-17. DM4JP8L RU https://pubmed.ncbi.nlm.nih.gov/18680274 DMBKOJG DI DMBKOJG DMBKOJG DN H-Dmt-Tic-Asp-NH-Bzl DMBKOJG MI TT27RFC DMBKOJG MN Opioid receptor delta (OPRD1) DMBKOJG MT DTT DMBKOJG MA Inhibitor DMBKOJG RN Further studies on lead compounds containing the opioid pharmacophore Dmt-Tic. J Med Chem. 2008 Aug 28;51(16):5109-17. DMBKOJG RU https://pubmed.ncbi.nlm.nih.gov/18680274 DMBKOJG DI DMBKOJG DMBKOJG DN H-Dmt-Tic-Asp-NH-Bzl DMBKOJG MI TTKWM86 DMBKOJG MN Opioid receptor mu (MOP) DMBKOJG MT DTT DMBKOJG MA Inhibitor DMBKOJG RN Further studies on lead compounds containing the opioid pharmacophore Dmt-Tic. J Med Chem. 2008 Aug 28;51(16):5109-17. DMBKOJG RU https://pubmed.ncbi.nlm.nih.gov/18680274 DM3W9FQ DI DM3W9FQ DM3W9FQ DN H-Dmt-Tic-Asp-NH-Ph DM3W9FQ MI TT27RFC DM3W9FQ MN Opioid receptor delta (OPRD1) DM3W9FQ MT DTT DM3W9FQ MA Inhibitor DM3W9FQ RN Further studies on lead compounds containing the opioid pharmacophore Dmt-Tic. J Med Chem. 2008 Aug 28;51(16):5109-17. DM3W9FQ RU https://pubmed.ncbi.nlm.nih.gov/18680274 DM3W9FQ DI DM3W9FQ DM3W9FQ DN H-Dmt-Tic-Asp-NH-Ph DM3W9FQ MI TTKWM86 DM3W9FQ MN Opioid receptor mu (MOP) DM3W9FQ MT DTT DM3W9FQ MA Inhibitor DM3W9FQ RN Further studies on lead compounds containing the opioid pharmacophore Dmt-Tic. J Med Chem. 2008 Aug 28;51(16):5109-17. DM3W9FQ RU https://pubmed.ncbi.nlm.nih.gov/18680274 DM483BG DI DM483BG DM483BG DN H-Dmt-Tic-D-Asp-N(Me)-Ph DM483BG MI TT27RFC DM483BG MN Opioid receptor delta (OPRD1) DM483BG MT DTT DM483BG MA Inhibitor DM483BG RN Further studies on lead compounds containing the opioid pharmacophore Dmt-Tic. J Med Chem. 2008 Aug 28;51(16):5109-17. DM483BG RU https://pubmed.ncbi.nlm.nih.gov/18680274 DM483BG DI DM483BG DM483BG DN H-Dmt-Tic-D-Asp-N(Me)-Ph DM483BG MI TTKWM86 DM483BG MN Opioid receptor mu (MOP) DM483BG MT DTT DM483BG MA Inhibitor DM483BG RN Further studies on lead compounds containing the opioid pharmacophore Dmt-Tic. J Med Chem. 2008 Aug 28;51(16):5109-17. DM483BG RU https://pubmed.ncbi.nlm.nih.gov/18680274 DMUG7X1 DI DMUG7X1 DMUG7X1 DN H-Dmt-Tic-D-Asp-NH-Ph DMUG7X1 MI TT27RFC DMUG7X1 MN Opioid receptor delta (OPRD1) DMUG7X1 MT DTT DMUG7X1 MA Inhibitor DMUG7X1 RN Further studies on lead compounds containing the opioid pharmacophore Dmt-Tic. J Med Chem. 2008 Aug 28;51(16):5109-17. DMUG7X1 RU https://pubmed.ncbi.nlm.nih.gov/18680274 DMUG7X1 DI DMUG7X1 DMUG7X1 DN H-Dmt-Tic-D-Asp-NH-Ph DMUG7X1 MI TTKWM86 DMUG7X1 MN Opioid receptor mu (MOP) DMUG7X1 MT DTT DMUG7X1 MA Inhibitor DMUG7X1 RN Further studies on lead compounds containing the opioid pharmacophore Dmt-Tic. J Med Chem. 2008 Aug 28;51(16):5109-17. DMUG7X1 RU https://pubmed.ncbi.nlm.nih.gov/18680274 DMQSRPD DI DMQSRPD DMQSRPD DN H-Dmt-Tic-Glu-Dap(6DMN)-NH(2) DMQSRPD MI TT27RFC DMQSRPD MN Opioid receptor delta (OPRD1) DMQSRPD MT DTT DMQSRPD MA Inhibitor DMQSRPD RN 6-N,N-dimethylamino-2,3-naphthalimide: a new environment-sensitive fluorescent probe in delta- and mu-selective opioid peptides. J Med Chem. 2006 Jun 15;49(12):3653-8. DMQSRPD RU https://pubmed.ncbi.nlm.nih.gov/16759107 DMQSRPD DI DMQSRPD DMQSRPD DN H-Dmt-Tic-Glu-Dap(6DMN)-NH(2) DMQSRPD MI TTKWM86 DMQSRPD MN Opioid receptor mu (MOP) DMQSRPD MT DTT DMQSRPD MA Inhibitor DMQSRPD RN 6-N,N-dimethylamino-2,3-naphthalimide: a new environment-sensitive fluorescent probe in delta- and mu-selective opioid peptides. J Med Chem. 2006 Jun 15;49(12):3653-8. DMQSRPD RU https://pubmed.ncbi.nlm.nih.gov/16759107 DMF52SH DI DMF52SH DMF52SH DN H-Dmt-Tic-Glu-NH-(CH2)5-NH2 DMF52SH MI TT27RFC DMF52SH MN Opioid receptor delta (OPRD1) DMF52SH MT DTT DMF52SH MA Inhibitor DMF52SH RN Highly selective fluorescent analogue of the potent delta-opioid receptor antagonist Dmt-Tic. J Med Chem. 2004 Dec 16;47(26):6541-6. DMF52SH RU https://pubmed.ncbi.nlm.nih.gov/15588089 DMF52SH DI DMF52SH DMF52SH DN H-Dmt-Tic-Glu-NH-(CH2)5-NH2 DMF52SH MI TTKWM86 DMF52SH MN Opioid receptor mu (MOP) DMF52SH MT DTT DMF52SH MA Inhibitor DMF52SH RN Highly selective fluorescent analogue of the potent delta-opioid receptor antagonist Dmt-Tic. J Med Chem. 2004 Dec 16;47(26):6541-6. DMF52SH RU https://pubmed.ncbi.nlm.nih.gov/15588089 DM8A573 DI DM8A573 DM8A573 DN H-Dmt-Tic-Glu-NH2 DM8A573 MI TT27RFC DM8A573 MN Opioid receptor delta (OPRD1) DM8A573 MT DTT DM8A573 MA Inhibitor DM8A573 RN Highly selective fluorescent analogue of the potent delta-opioid receptor antagonist Dmt-Tic. J Med Chem. 2004 Dec 16;47(26):6541-6. DM8A573 RU https://pubmed.ncbi.nlm.nih.gov/15588089 DM8A573 DI DM8A573 DM8A573 DN H-Dmt-Tic-Glu-NH2 DM8A573 MI TTKWM86 DM8A573 MN Opioid receptor mu (MOP) DM8A573 MT DTT DM8A573 MA Inhibitor DM8A573 RN Highly selective fluorescent analogue of the potent delta-opioid receptor antagonist Dmt-Tic. J Med Chem. 2004 Dec 16;47(26):6541-6. DM8A573 RU https://pubmed.ncbi.nlm.nih.gov/15588089 DMHYKBC DI DMHYKBC DMHYKBC DN H-Dmt-Tic-Gly-N(Me)-Ph DMHYKBC MI TT27RFC DMHYKBC MN Opioid receptor delta (OPRD1) DMHYKBC MT DTT DMHYKBC MA Inhibitor DMHYKBC RN Further studies on lead compounds containing the opioid pharmacophore Dmt-Tic. J Med Chem. 2008 Aug 28;51(16):5109-17. DMHYKBC RU https://pubmed.ncbi.nlm.nih.gov/18680274 DMHYKBC DI DMHYKBC DMHYKBC DN H-Dmt-Tic-Gly-N(Me)-Ph DMHYKBC MI TTKWM86 DMHYKBC MN Opioid receptor mu (MOP) DMHYKBC MT DTT DMHYKBC MA Inhibitor DMHYKBC RN Further studies on lead compounds containing the opioid pharmacophore Dmt-Tic. J Med Chem. 2008 Aug 28;51(16):5109-17. DMHYKBC RU https://pubmed.ncbi.nlm.nih.gov/18680274 DMM39YW DI DMM39YW DMM39YW DN H-Dmt-Tic-Gly-NH-Bzl DMM39YW MI TT27RFC DMM39YW MN Opioid receptor delta (OPRD1) DMM39YW MT DTT DMM39YW MA Inhibitor DMM39YW RN Further studies on lead compounds containing the opioid pharmacophore Dmt-Tic. J Med Chem. 2008 Aug 28;51(16):5109-17. DMM39YW RU https://pubmed.ncbi.nlm.nih.gov/18680274 DMM39YW DI DMM39YW DMM39YW DN H-Dmt-Tic-Gly-NH-Bzl DMM39YW MI TTKWM86 DMM39YW MN Opioid receptor mu (MOP) DMM39YW MT DTT DMM39YW MA Inhibitor DMM39YW RN Further studies on lead compounds containing the opioid pharmacophore Dmt-Tic. J Med Chem. 2008 Aug 28;51(16):5109-17. DMM39YW RU https://pubmed.ncbi.nlm.nih.gov/18680274 DMH6JOU DI DMH6JOU DMH6JOU DN H-Dmt-Tic-Gly-NH-CH2-Bid DMH6JOU MI TT27RFC DMH6JOU MN Opioid receptor delta (OPRD1) DMH6JOU MT DTT DMH6JOU MA Inhibitor DMH6JOU RN New 2',6'-dimethyl-L-tyrosine (Dmt) opioid peptidomimetics based on the Aba-Gly scaffold. Development of unique mu-opioid receptor ligands. J Med Chem. 2006 Jun 29;49(13):3990-3. DMH6JOU RU https://pubmed.ncbi.nlm.nih.gov/16789756 DMH6JOU DI DMH6JOU DMH6JOU DN H-Dmt-Tic-Gly-NH-CH2-Bid DMH6JOU MI TTKWM86 DMH6JOU MN Opioid receptor mu (MOP) DMH6JOU MT DTT DMH6JOU MA Inhibitor DMH6JOU RN New 2',6'-dimethyl-L-tyrosine (Dmt) opioid peptidomimetics based on the Aba-Gly scaffold. Development of unique mu-opioid receptor ligands. J Med Chem. 2006 Jun 29;49(13):3990-3. DMH6JOU RU https://pubmed.ncbi.nlm.nih.gov/16789756 DMIZ28H DI DMIZ28H DMIZ28H DN H-Dmt-Tic-Gly-NH-Ph DMIZ28H MI TT27RFC DMIZ28H MN Opioid receptor delta (OPRD1) DMIZ28H MT DTT DMIZ28H MA Inhibitor DMIZ28H RN Further studies on lead compounds containing the opioid pharmacophore Dmt-Tic. J Med Chem. 2008 Aug 28;51(16):5109-17. DMIZ28H RU https://pubmed.ncbi.nlm.nih.gov/18680274 DMIZ28H DI DMIZ28H DMIZ28H DN H-Dmt-Tic-Gly-NH-Ph DMIZ28H MI TTKWM86 DMIZ28H MN Opioid receptor mu (MOP) DMIZ28H MT DTT DMIZ28H MA Inhibitor DMIZ28H RN Further studies on lead compounds containing the opioid pharmacophore Dmt-Tic. J Med Chem. 2008 Aug 28;51(16):5109-17. DMIZ28H RU https://pubmed.ncbi.nlm.nih.gov/18680274 DM2TY43 DI DM2TY43 DM2TY43 DN H-Dmt-Tic-Lys(Ac)-NH-CH2-Ph DM2TY43 MI TT27RFC DM2TY43 MN Opioid receptor delta (OPRD1) DM2TY43 MT DTT DM2TY43 MA Inhibitor DM2TY43 RN Effect of lysine at C-terminus of the Dmt-Tic opioid pharmacophore. J Med Chem. 2006 Sep 7;49(18):5610-7. DM2TY43 RU https://pubmed.ncbi.nlm.nih.gov/16942034 DM2TY43 DI DM2TY43 DM2TY43 DN H-Dmt-Tic-Lys(Ac)-NH-CH2-Ph DM2TY43 MI TTKWM86 DM2TY43 MN Opioid receptor mu (MOP) DM2TY43 MT DTT DM2TY43 MA Inhibitor DM2TY43 RN Effect of lysine at C-terminus of the Dmt-Tic opioid pharmacophore. J Med Chem. 2006 Sep 7;49(18):5610-7. DM2TY43 RU https://pubmed.ncbi.nlm.nih.gov/16942034 DMZH9P5 DI DMZH9P5 DMZH9P5 DN H-Dmt-Tic-Lys(Ac)-NH-Ph DMZH9P5 MI TT27RFC DMZH9P5 MN Opioid receptor delta (OPRD1) DMZH9P5 MT DTT DMZH9P5 MA Inhibitor DMZH9P5 RN Effect of lysine at C-terminus of the Dmt-Tic opioid pharmacophore. J Med Chem. 2006 Sep 7;49(18):5610-7. DMZH9P5 RU https://pubmed.ncbi.nlm.nih.gov/16942034 DMZH9P5 DI DMZH9P5 DMZH9P5 DN H-Dmt-Tic-Lys(Ac)-NH-Ph DMZH9P5 MI TTKWM86 DMZH9P5 MN Opioid receptor mu (MOP) DMZH9P5 MT DTT DMZH9P5 MA Inhibitor DMZH9P5 RN Effect of lysine at C-terminus of the Dmt-Tic opioid pharmacophore. J Med Chem. 2006 Sep 7;49(18):5610-7. DMZH9P5 RU https://pubmed.ncbi.nlm.nih.gov/16942034 DMP8HFA DI DMP8HFA DMP8HFA DN H-Dmt-Tic-Lys(Z)-NH-CH2-Ph DMP8HFA MI TT27RFC DMP8HFA MN Opioid receptor delta (OPRD1) DMP8HFA MT DTT DMP8HFA MA Inhibitor DMP8HFA RN Effect of lysine at C-terminus of the Dmt-Tic opioid pharmacophore. J Med Chem. 2006 Sep 7;49(18):5610-7. DMP8HFA RU https://pubmed.ncbi.nlm.nih.gov/16942034 DMP8HFA DI DMP8HFA DMP8HFA DN H-Dmt-Tic-Lys(Z)-NH-CH2-Ph DMP8HFA MI TTKWM86 DMP8HFA MN Opioid receptor mu (MOP) DMP8HFA MT DTT DMP8HFA MA Inhibitor DMP8HFA RN Effect of lysine at C-terminus of the Dmt-Tic opioid pharmacophore. J Med Chem. 2006 Sep 7;49(18):5610-7. DMP8HFA RU https://pubmed.ncbi.nlm.nih.gov/16942034 DMBXGLA DI DMBXGLA DMBXGLA DN H-Dmt-Tic-Lys(Z)-NH-Ph DMBXGLA MI TT27RFC DMBXGLA MN Opioid receptor delta (OPRD1) DMBXGLA MT DTT DMBXGLA MA Inhibitor DMBXGLA RN Effect of lysine at C-terminus of the Dmt-Tic opioid pharmacophore. J Med Chem. 2006 Sep 7;49(18):5610-7. DMBXGLA RU https://pubmed.ncbi.nlm.nih.gov/16942034 DMBXGLA DI DMBXGLA DMBXGLA DN H-Dmt-Tic-Lys(Z)-NH-Ph DMBXGLA MI TTKWM86 DMBXGLA MN Opioid receptor mu (MOP) DMBXGLA MT DTT DMBXGLA MA Inhibitor DMBXGLA RN Effect of lysine at C-terminus of the Dmt-Tic opioid pharmacophore. J Med Chem. 2006 Sep 7;49(18):5610-7. DMBXGLA RU https://pubmed.ncbi.nlm.nih.gov/16942034 DMDJ9PE DI DMDJ9PE DMDJ9PE DN H-Dmt-Tic-Lys-NH-CH2-Ph DMDJ9PE MI TT27RFC DMDJ9PE MN Opioid receptor delta (OPRD1) DMDJ9PE MT DTT DMDJ9PE MA Inhibitor DMDJ9PE RN Effect of lysine at C-terminus of the Dmt-Tic opioid pharmacophore. J Med Chem. 2006 Sep 7;49(18):5610-7. DMDJ9PE RU https://pubmed.ncbi.nlm.nih.gov/16942034 DMDJ9PE DI DMDJ9PE DMDJ9PE DN H-Dmt-Tic-Lys-NH-CH2-Ph DMDJ9PE MI TTKWM86 DMDJ9PE MN Opioid receptor mu (MOP) DMDJ9PE MT DTT DMDJ9PE MA Inhibitor DMDJ9PE RN Effect of lysine at C-terminus of the Dmt-Tic opioid pharmacophore. J Med Chem. 2006 Sep 7;49(18):5610-7. DMDJ9PE RU https://pubmed.ncbi.nlm.nih.gov/16942034 DMT3Y6E DI DMT3Y6E DMT3Y6E DN H-Dmt-Tic-Lys-NH-Ph DMT3Y6E MI TT27RFC DMT3Y6E MN Opioid receptor delta (OPRD1) DMT3Y6E MT DTT DMT3Y6E MA Inhibitor DMT3Y6E RN Effect of lysine at C-terminus of the Dmt-Tic opioid pharmacophore. J Med Chem. 2006 Sep 7;49(18):5610-7. DMT3Y6E RU https://pubmed.ncbi.nlm.nih.gov/16942034 DMT3Y6E DI DMT3Y6E DMT3Y6E DN H-Dmt-Tic-Lys-NH-Ph DMT3Y6E MI TTKWM86 DMT3Y6E MN Opioid receptor mu (MOP) DMT3Y6E MT DTT DMT3Y6E MA Inhibitor DMT3Y6E RN Effect of lysine at C-terminus of the Dmt-Tic opioid pharmacophore. J Med Chem. 2006 Sep 7;49(18):5610-7. DMT3Y6E RU https://pubmed.ncbi.nlm.nih.gov/16942034 DMMJ9YN DI DMMJ9YN DMMJ9YN DN H-Dmt-Tic-NH-(CH2)6-NH-Dmt-H DMMJ9YN MI TT27RFC DMMJ9YN MN Opioid receptor delta (OPRD1) DMMJ9YN MT DTT DMMJ9YN MA Inhibitor DMMJ9YN RN New series of potent delta-opioid antagonists containing the H-Dmt-Tic-NH-hexyl-NH-R motif. Bioorg Med Chem Lett. 2005 Dec 15;15(24):5517-20. DMMJ9YN RU https://pubmed.ncbi.nlm.nih.gov/16183273 DMMJ9YN DI DMMJ9YN DMMJ9YN DN H-Dmt-Tic-NH-(CH2)6-NH-Dmt-H DMMJ9YN MI TTKWM86 DMMJ9YN MN Opioid receptor mu (MOP) DMMJ9YN MT DTT DMMJ9YN MA Inhibitor DMMJ9YN RN New series of potent delta-opioid antagonists containing the H-Dmt-Tic-NH-hexyl-NH-R motif. Bioorg Med Chem Lett. 2005 Dec 15;15(24):5517-20. DMMJ9YN RU https://pubmed.ncbi.nlm.nih.gov/16183273 DM0BGNE DI DM0BGNE DM0BGNE DN H-Dmt-Tic-NH-(CH2)6-NH-Phe-H DM0BGNE MI TT27RFC DM0BGNE MN Opioid receptor delta (OPRD1) DM0BGNE MT DTT DM0BGNE MA Inhibitor DM0BGNE RN New series of potent delta-opioid antagonists containing the H-Dmt-Tic-NH-hexyl-NH-R motif. Bioorg Med Chem Lett. 2005 Dec 15;15(24):5517-20. DM0BGNE RU https://pubmed.ncbi.nlm.nih.gov/16183273 DM0BGNE DI DM0BGNE DM0BGNE DN H-Dmt-Tic-NH-(CH2)6-NH-Phe-H DM0BGNE MI TTKWM86 DM0BGNE MN Opioid receptor mu (MOP) DM0BGNE MT DTT DM0BGNE MA Inhibitor DM0BGNE RN New series of potent delta-opioid antagonists containing the H-Dmt-Tic-NH-hexyl-NH-R motif. Bioorg Med Chem Lett. 2005 Dec 15;15(24):5517-20. DM0BGNE RU https://pubmed.ncbi.nlm.nih.gov/16183273 DMQ586T DI DMQ586T DMQ586T DN H-Dmt-Tic-NH-(CH2)6-NH-Tic-H DMQ586T MI TT27RFC DMQ586T MN Opioid receptor delta (OPRD1) DMQ586T MT DTT DMQ586T MA Inhibitor DMQ586T RN New series of potent delta-opioid antagonists containing the H-Dmt-Tic-NH-hexyl-NH-R motif. Bioorg Med Chem Lett. 2005 Dec 15;15(24):5517-20. DMQ586T RU https://pubmed.ncbi.nlm.nih.gov/16183273 DMQ586T DI DMQ586T DMQ586T DN H-Dmt-Tic-NH-(CH2)6-NH-Tic-H DMQ586T MI TTKWM86 DMQ586T MN Opioid receptor mu (MOP) DMQ586T MT DTT DMQ586T MA Inhibitor DMQ586T RN New series of potent delta-opioid antagonists containing the H-Dmt-Tic-NH-hexyl-NH-R motif. Bioorg Med Chem Lett. 2005 Dec 15;15(24):5517-20. DMQ586T RU https://pubmed.ncbi.nlm.nih.gov/16183273 DMAU2H6 DI DMAU2H6 DMAU2H6 DN H-Dmt-Tic-NH-(D)-CH[(CH2)4-NH-Z]-Bid DMAU2H6 MI TT27RFC DMAU2H6 MN Opioid receptor delta (OPRD1) DMAU2H6 MT DTT DMAU2H6 MA Inhibitor DMAU2H6 RN Effect of lysine at C-terminus of the Dmt-Tic opioid pharmacophore. J Med Chem. 2006 Sep 7;49(18):5610-7. DMAU2H6 RU https://pubmed.ncbi.nlm.nih.gov/16942034 DMAU2H6 DI DMAU2H6 DMAU2H6 DN H-Dmt-Tic-NH-(D)-CH[(CH2)4-NH-Z]-Bid DMAU2H6 MI TTKWM86 DMAU2H6 MN Opioid receptor mu (MOP) DMAU2H6 MT DTT DMAU2H6 MA Inhibitor DMAU2H6 RN Effect of lysine at C-terminus of the Dmt-Tic opioid pharmacophore. J Med Chem. 2006 Sep 7;49(18):5610-7. DMAU2H6 RU https://pubmed.ncbi.nlm.nih.gov/16942034 DM5TZ1J DI DM5TZ1J DM5TZ1J DN H-Dmt-Tic-NH-(R)CH(CH2-COOH)-Bid DM5TZ1J MI TT27RFC DM5TZ1J MN Opioid receptor delta (OPRD1) DM5TZ1J MT DTT DM5TZ1J MA Inhibitor DM5TZ1J RN Further studies on lead compounds containing the opioid pharmacophore Dmt-Tic. J Med Chem. 2008 Aug 28;51(16):5109-17. DM5TZ1J RU https://pubmed.ncbi.nlm.nih.gov/18680274 DM5TZ1J DI DM5TZ1J DM5TZ1J DN H-Dmt-Tic-NH-(R)CH(CH2-COOH)-Bid DM5TZ1J MI TTKWM86 DM5TZ1J MN Opioid receptor mu (MOP) DM5TZ1J MT DTT DM5TZ1J MA Inhibitor DM5TZ1J RN Further studies on lead compounds containing the opioid pharmacophore Dmt-Tic. J Med Chem. 2008 Aug 28;51(16):5109-17. DM5TZ1J RU https://pubmed.ncbi.nlm.nih.gov/18680274 DMIDLPT DI DMIDLPT DMIDLPT DN H-Dmt-Tic-NH-(R)CH(CH2-COOH)-Bid(N1-Me) DMIDLPT MI TT27RFC DMIDLPT MN Opioid receptor delta (OPRD1) DMIDLPT MT DTT DMIDLPT MA Inhibitor DMIDLPT RN Further studies on lead compounds containing the opioid pharmacophore Dmt-Tic. J Med Chem. 2008 Aug 28;51(16):5109-17. DMIDLPT RU https://pubmed.ncbi.nlm.nih.gov/18680274 DMIDLPT DI DMIDLPT DMIDLPT DN H-Dmt-Tic-NH-(R)CH(CH2-COOH)-Bid(N1-Me) DMIDLPT MI TTKWM86 DMIDLPT MN Opioid receptor mu (MOP) DMIDLPT MT DTT DMIDLPT MA Inhibitor DMIDLPT RN Further studies on lead compounds containing the opioid pharmacophore Dmt-Tic. J Med Chem. 2008 Aug 28;51(16):5109-17. DMIDLPT RU https://pubmed.ncbi.nlm.nih.gov/18680274 DMNEAQ9 DI DMNEAQ9 DMNEAQ9 DN H-Dmt-Tic-NH-(S)CH(CH2-COOH)-Bid(N1-Me) DMNEAQ9 MI TT27RFC DMNEAQ9 MN Opioid receptor delta (OPRD1) DMNEAQ9 MT DTT DMNEAQ9 MA Inhibitor DMNEAQ9 RN Further studies on lead compounds containing the opioid pharmacophore Dmt-Tic. J Med Chem. 2008 Aug 28;51(16):5109-17. DMNEAQ9 RU https://pubmed.ncbi.nlm.nih.gov/18680274 DMNEAQ9 DI DMNEAQ9 DMNEAQ9 DN H-Dmt-Tic-NH-(S)CH(CH2-COOH)-Bid(N1-Me) DMNEAQ9 MI TTKWM86 DMNEAQ9 MN Opioid receptor mu (MOP) DMNEAQ9 MT DTT DMNEAQ9 MA Inhibitor DMNEAQ9 RN Further studies on lead compounds containing the opioid pharmacophore Dmt-Tic. J Med Chem. 2008 Aug 28;51(16):5109-17. DMNEAQ9 RU https://pubmed.ncbi.nlm.nih.gov/18680274 DMQEDP5 DI DMQEDP5 DMQEDP5 DN H-Dmt-Tic-NH-CH[(CH2)4-NH2]-Bid DMQEDP5 MI TT27RFC DMQEDP5 MN Opioid receptor delta (OPRD1) DMQEDP5 MT DTT DMQEDP5 MA Inhibitor DMQEDP5 RN Effect of lysine at C-terminus of the Dmt-Tic opioid pharmacophore. J Med Chem. 2006 Sep 7;49(18):5610-7. DMQEDP5 RU https://pubmed.ncbi.nlm.nih.gov/16942034 DMQEDP5 DI DMQEDP5 DMQEDP5 DN H-Dmt-Tic-NH-CH[(CH2)4-NH2]-Bid DMQEDP5 MI TTKWM86 DMQEDP5 MN Opioid receptor mu (MOP) DMQEDP5 MT DTT DMQEDP5 MA Inhibitor DMQEDP5 RN Effect of lysine at C-terminus of the Dmt-Tic opioid pharmacophore. J Med Chem. 2006 Sep 7;49(18):5610-7. DMQEDP5 RU https://pubmed.ncbi.nlm.nih.gov/16942034 DM8PJ92 DI DM8PJ92 DM8PJ92 DN H-Dmt-Tic-NH-CH[(CH2)4-NH-Ac]-Bid DM8PJ92 MI TT27RFC DM8PJ92 MN Opioid receptor delta (OPRD1) DM8PJ92 MT DTT DM8PJ92 MA Inhibitor DM8PJ92 RN Effect of lysine at C-terminus of the Dmt-Tic opioid pharmacophore. J Med Chem. 2006 Sep 7;49(18):5610-7. DM8PJ92 RU https://pubmed.ncbi.nlm.nih.gov/16942034 DM8PJ92 DI DM8PJ92 DM8PJ92 DN H-Dmt-Tic-NH-CH[(CH2)4-NH-Ac]-Bid DM8PJ92 MI TTKWM86 DM8PJ92 MN Opioid receptor mu (MOP) DM8PJ92 MT DTT DM8PJ92 MA Inhibitor DM8PJ92 RN Effect of lysine at C-terminus of the Dmt-Tic opioid pharmacophore. J Med Chem. 2006 Sep 7;49(18):5610-7. DM8PJ92 RU https://pubmed.ncbi.nlm.nih.gov/16942034 DMQ4ILK DI DMQ4ILK DMQ4ILK DN H-Dmt-Tic-NH-CH[(CH2)4-NH-Z]-Bid DMQ4ILK MI TT27RFC DMQ4ILK MN Opioid receptor delta (OPRD1) DMQ4ILK MT DTT DMQ4ILK MA Inhibitor DMQ4ILK RN Effect of lysine at C-terminus of the Dmt-Tic opioid pharmacophore. J Med Chem. 2006 Sep 7;49(18):5610-7. DMQ4ILK RU https://pubmed.ncbi.nlm.nih.gov/16942034 DMQ4ILK DI DMQ4ILK DMQ4ILK DN H-Dmt-Tic-NH-CH[(CH2)4-NH-Z]-Bid DMQ4ILK MI TTKWM86 DMQ4ILK MN Opioid receptor mu (MOP) DMQ4ILK MT DTT DMQ4ILK MA Inhibitor DMQ4ILK RN Effect of lysine at C-terminus of the Dmt-Tic opioid pharmacophore. J Med Chem. 2006 Sep 7;49(18):5610-7. DMQ4ILK RU https://pubmed.ncbi.nlm.nih.gov/16942034 DM4IUCW DI DM4IUCW DM4IUCW DN H-Dmt-Tic-NH-CH2-Boa DM4IUCW MI TT27RFC DM4IUCW MN Opioid receptor delta (OPRD1) DM4IUCW MT DTT DM4IUCW MA Inhibitor DM4IUCW RN Role of benzimidazole (Bid) in the delta-opioid agonist pseudopeptide H-Dmt-Tic-NH-CH(2)-Bid (UFP-502). Bioorg Med Chem. 2008 Mar 15;16(6):3032-8. DM4IUCW RU https://pubmed.ncbi.nlm.nih.gov/18178091 DM4IUCW DI DM4IUCW DM4IUCW DN H-Dmt-Tic-NH-CH2-Boa DM4IUCW MI TTKWM86 DM4IUCW MN Opioid receptor mu (MOP) DM4IUCW MT DTT DM4IUCW MA Inhibitor DM4IUCW RN Role of benzimidazole (Bid) in the delta-opioid agonist pseudopeptide H-Dmt-Tic-NH-CH(2)-Bid (UFP-502). Bioorg Med Chem. 2008 Mar 15;16(6):3032-8. DM4IUCW RU https://pubmed.ncbi.nlm.nih.gov/18178091 DMZ8C0U DI DMZ8C0U DMZ8C0U DN H-Dmt-Tic-NH-CH2-Bta DMZ8C0U MI TT27RFC DMZ8C0U MN Opioid receptor delta (OPRD1) DMZ8C0U MT DTT DMZ8C0U MA Inhibitor DMZ8C0U RN Role of benzimidazole (Bid) in the delta-opioid agonist pseudopeptide H-Dmt-Tic-NH-CH(2)-Bid (UFP-502). Bioorg Med Chem. 2008 Mar 15;16(6):3032-8. DMZ8C0U RU https://pubmed.ncbi.nlm.nih.gov/18178091 DMZ8C0U DI DMZ8C0U DMZ8C0U DN H-Dmt-Tic-NH-CH2-Bta DMZ8C0U MI TTKWM86 DMZ8C0U MN Opioid receptor mu (MOP) DMZ8C0U MT DTT DMZ8C0U MA Inhibitor DMZ8C0U RN Role of benzimidazole (Bid) in the delta-opioid agonist pseudopeptide H-Dmt-Tic-NH-CH(2)-Bid (UFP-502). Bioorg Med Chem. 2008 Mar 15;16(6):3032-8. DMZ8C0U RU https://pubmed.ncbi.nlm.nih.gov/18178091 DMYJAW4 DI DMYJAW4 DMYJAW4 DN H-Dmt-Tic-NH-CH2-CH2-NH2 DMYJAW4 MI TT27RFC DMYJAW4 MN Opioid receptor delta (OPRD1) DMYJAW4 MT DTT DMYJAW4 MA Inhibitor DMYJAW4 RN A new opioid designed multiple ligand derived from the micro opioid agonist endomorphin-2 and the delta opioid antagonist pharmacophore Dmt-Tic. Bioorg Med Chem. 2007 Nov 15;15(22):6876-81. DMYJAW4 RU https://pubmed.ncbi.nlm.nih.gov/17851080 DMYJAW4 DI DMYJAW4 DMYJAW4 DN H-Dmt-Tic-NH-CH2-CH2-NH2 DMYJAW4 MI TTKWM86 DMYJAW4 MN Opioid receptor mu (MOP) DMYJAW4 MT DTT DMYJAW4 MA Inhibitor DMYJAW4 RN A new opioid designed multiple ligand derived from the micro opioid agonist endomorphin-2 and the delta opioid antagonist pharmacophore Dmt-Tic. Bioorg Med Chem. 2007 Nov 15;15(22):6876-81. DMYJAW4 RU https://pubmed.ncbi.nlm.nih.gov/17851080 DMJ2F8M DI DMJ2F8M DMJ2F8M DN H-Dmt-Tic-NH-CH2-Imid DMJ2F8M MI TT27RFC DMJ2F8M MN Opioid receptor delta (OPRD1) DMJ2F8M MT DTT DMJ2F8M MA Inhibitor DMJ2F8M RN Role of benzimidazole (Bid) in the delta-opioid agonist pseudopeptide H-Dmt-Tic-NH-CH(2)-Bid (UFP-502). Bioorg Med Chem. 2008 Mar 15;16(6):3032-8. DMJ2F8M RU https://pubmed.ncbi.nlm.nih.gov/18178091 DMJ2F8M DI DMJ2F8M DMJ2F8M DN H-Dmt-Tic-NH-CH2-Imid DMJ2F8M MI TTKWM86 DMJ2F8M MN Opioid receptor mu (MOP) DMJ2F8M MT DTT DMJ2F8M MA Inhibitor DMJ2F8M RN Role of benzimidazole (Bid) in the delta-opioid agonist pseudopeptide H-Dmt-Tic-NH-CH(2)-Bid (UFP-502). Bioorg Med Chem. 2008 Mar 15;16(6):3032-8. DMJ2F8M RU https://pubmed.ncbi.nlm.nih.gov/18178091 DMKGIQJ DI DMKGIQJ DMKGIQJ DN H-Dmt-Tic-NH-CH2-ImidPh DMKGIQJ MI TT27RFC DMKGIQJ MN Opioid receptor delta (OPRD1) DMKGIQJ MT DTT DMKGIQJ MA Inhibitor DMKGIQJ RN Role of benzimidazole (Bid) in the delta-opioid agonist pseudopeptide H-Dmt-Tic-NH-CH(2)-Bid (UFP-502). Bioorg Med Chem. 2008 Mar 15;16(6):3032-8. DMKGIQJ RU https://pubmed.ncbi.nlm.nih.gov/18178091 DMKGIQJ DI DMKGIQJ DMKGIQJ DN H-Dmt-Tic-NH-CH2-ImidPh DMKGIQJ MI TTKWM86 DMKGIQJ MN Opioid receptor mu (MOP) DMKGIQJ MT DTT DMKGIQJ MA Inhibitor DMKGIQJ RN Role of benzimidazole (Bid) in the delta-opioid agonist pseudopeptide H-Dmt-Tic-NH-CH(2)-Bid (UFP-502). Bioorg Med Chem. 2008 Mar 15;16(6):3032-8. DMKGIQJ RU https://pubmed.ncbi.nlm.nih.gov/18178091 DMNY3A1 DI DMNY3A1 DMNY3A1 DN H-Dmt-Tic-NH-CH2-Indl DMNY3A1 MI TT27RFC DMNY3A1 MN Opioid receptor delta (OPRD1) DMNY3A1 MT DTT DMNY3A1 MA Inhibitor DMNY3A1 RN Role of benzimidazole (Bid) in the delta-opioid agonist pseudopeptide H-Dmt-Tic-NH-CH(2)-Bid (UFP-502). Bioorg Med Chem. 2008 Mar 15;16(6):3032-8. DMNY3A1 RU https://pubmed.ncbi.nlm.nih.gov/18178091 DMNY3A1 DI DMNY3A1 DMNY3A1 DN H-Dmt-Tic-NH-CH2-Indl DMNY3A1 MI TTKWM86 DMNY3A1 MN Opioid receptor mu (MOP) DMNY3A1 MT DTT DMNY3A1 MA Inhibitor DMNY3A1 RN Role of benzimidazole (Bid) in the delta-opioid agonist pseudopeptide H-Dmt-Tic-NH-CH(2)-Bid (UFP-502). Bioorg Med Chem. 2008 Mar 15;16(6):3032-8. DMNY3A1 RU https://pubmed.ncbi.nlm.nih.gov/18178091 DMZWUFK DI DMZWUFK DMZWUFK DN H-Dmt-Tic-NH-CH2-Indn DMZWUFK MI TT27RFC DMZWUFK MN Opioid receptor delta (OPRD1) DMZWUFK MT DTT DMZWUFK MA Inhibitor DMZWUFK RN Role of benzimidazole (Bid) in the delta-opioid agonist pseudopeptide H-Dmt-Tic-NH-CH(2)-Bid (UFP-502). Bioorg Med Chem. 2008 Mar 15;16(6):3032-8. DMZWUFK RU https://pubmed.ncbi.nlm.nih.gov/18178091 DMZWUFK DI DMZWUFK DMZWUFK DN H-Dmt-Tic-NH-CH2-Indn DMZWUFK MI TTKWM86 DMZWUFK MN Opioid receptor mu (MOP) DMZWUFK MT DTT DMZWUFK MA Inhibitor DMZWUFK RN Role of benzimidazole (Bid) in the delta-opioid agonist pseudopeptide H-Dmt-Tic-NH-CH(2)-Bid (UFP-502). Bioorg Med Chem. 2008 Mar 15;16(6):3032-8. DMZWUFK RU https://pubmed.ncbi.nlm.nih.gov/18178091 DML8S7J DI DML8S7J DML8S7J DN H-D-Phe-c[Cys-Ala-D-Trp-Lys-Thr-Cys]-Thr-NH2 DML8S7J MI TTZ6T9E DML8S7J MN Somatostatin receptor type 2 (SSTR2) DML8S7J MT DTT DML8S7J MA Inhibitor DML8S7J RN Novel sst2-selective somatostatin agonists. Three-dimensional consensus structure by NMR. J Med Chem. 2006 Jul 27;49(15):4487-96. DML8S7J RU https://pubmed.ncbi.nlm.nih.gov/16854054 DML8S7J DI DML8S7J DML8S7J DN H-D-Phe-c[Cys-Ala-D-Trp-Lys-Thr-Cys]-Thr-NH2 DML8S7J MI TTJX3UE DML8S7J MN Somatostatin receptor type 3 (SSTR3) DML8S7J MT DTT DML8S7J MA Inhibitor DML8S7J RN Novel sst2-selective somatostatin agonists. Three-dimensional consensus structure by NMR. J Med Chem. 2006 Jul 27;49(15):4487-96. DML8S7J RU https://pubmed.ncbi.nlm.nih.gov/16854054 DML8S7J DI DML8S7J DML8S7J DN H-D-Phe-c[Cys-Ala-D-Trp-Lys-Thr-Cys]-Thr-NH2 DML8S7J MI TT2BC4G DML8S7J MN Somatostatin receptor type 5 (SSTR5) DML8S7J MT DTT DML8S7J MA Inhibitor DML8S7J RN Novel sst2-selective somatostatin agonists. Three-dimensional consensus structure by NMR. J Med Chem. 2006 Jul 27;49(15):4487-96. DML8S7J RU https://pubmed.ncbi.nlm.nih.gov/16854054 DMLCIZ8 DI DMLCIZ8 DMLCIZ8 DN H-DPhe-c[Cys-Phe-DTrp-Lys-Thr-Cys]-Thr-NH2 DMLCIZ8 MI TTZ6T9E DMLCIZ8 MN Somatostatin receptor type 2 (SSTR2) DMLCIZ8 MT DTT DMLCIZ8 MA Inhibitor DMLCIZ8 RN Novel sst2-selective somatostatin agonists. Three-dimensional consensus structure by NMR. J Med Chem. 2006 Jul 27;49(15):4487-96. DMLCIZ8 RU https://pubmed.ncbi.nlm.nih.gov/16854054 DMLCIZ8 DI DMLCIZ8 DMLCIZ8 DN H-DPhe-c[Cys-Phe-DTrp-Lys-Thr-Cys]-Thr-NH2 DMLCIZ8 MI TTJX3UE DMLCIZ8 MN Somatostatin receptor type 3 (SSTR3) DMLCIZ8 MT DTT DMLCIZ8 MA Inhibitor DMLCIZ8 RN Novel sst2-selective somatostatin agonists. Three-dimensional consensus structure by NMR. J Med Chem. 2006 Jul 27;49(15):4487-96. DMLCIZ8 RU https://pubmed.ncbi.nlm.nih.gov/16854054 DMLCIZ8 DI DMLCIZ8 DMLCIZ8 DN H-DPhe-c[Cys-Phe-DTrp-Lys-Thr-Cys]-Thr-NH2 DMLCIZ8 MI TT2BC4G DMLCIZ8 MN Somatostatin receptor type 5 (SSTR5) DMLCIZ8 MT DTT DMLCIZ8 MA Inhibitor DMLCIZ8 RN Novel sst2-selective somatostatin agonists. Three-dimensional consensus structure by NMR. J Med Chem. 2006 Jul 27;49(15):4487-96. DMLCIZ8 RU https://pubmed.ncbi.nlm.nih.gov/16854054 DM1EGC3 DI DM1EGC3 DM1EGC3 DN H-D-Phe-Cys-Tyr-D-Trp-Lys-Val-Cys-Thr-NH2 DM1EGC3 MI TTZ6T9E DM1EGC3 MN Somatostatin receptor type 2 (SSTR2) DM1EGC3 MT DTT DM1EGC3 MA Inhibitor DM1EGC3 RN Discovery of iodinated somatostatin analogues selective for hsst2 and hsst5 with excellent inhibition of growth hormone and prolactin release from ... J Med Chem. 2005 Oct 20;48(21):6643-52. DM1EGC3 RU https://pubmed.ncbi.nlm.nih.gov/16220980 DM1EGC3 DI DM1EGC3 DM1EGC3 DN H-D-Phe-Cys-Tyr-D-Trp-Lys-Val-Cys-Thr-NH2 DM1EGC3 MI TT2BC4G DM1EGC3 MN Somatostatin receptor type 5 (SSTR5) DM1EGC3 MT DTT DM1EGC3 MA Inhibitor DM1EGC3 RN Discovery of iodinated somatostatin analogues selective for hsst2 and hsst5 with excellent inhibition of growth hormone and prolactin release from ... J Med Chem. 2005 Oct 20;48(21):6643-52. DM1EGC3 RU https://pubmed.ncbi.nlm.nih.gov/16220980 DMLRUVA DI DMLRUVA DMLRUVA DN HDS-029 DMLRUVA MI TTGKNB4 DMLRUVA MN Epidermal growth factor receptor (EGFR) DMLRUVA MT DTT DMLRUVA MA Inhibitor DMLRUVA RN Tyrosine kinase inhibitors. 19. 6-Alkynamides of 4-anilinoquinazolines and 4-anilinopyrido[3,4-d]pyrimidines as irreversible inhibitors of the erbB... J Med Chem. 2006 Feb 23;49(4):1475-85. DMLRUVA RU https://pubmed.ncbi.nlm.nih.gov/16480284 DMLRUVA DI DMLRUVA DMLRUVA DN HDS-029 DMLRUVA MI TTR5TV4 DMLRUVA MN ERBB2 messenger RNA (HER2 mRNA) DMLRUVA MT DTT DMLRUVA MA Inhibitor DMLRUVA RN Tyrosine kinase inhibitors. 19. 6-Alkynamides of 4-anilinoquinazolines and 4-anilinopyrido[3,4-d]pyrimidines as irreversible inhibitors of the erbB... J Med Chem. 2006 Feb 23;49(4):1475-85. DMLRUVA RU https://pubmed.ncbi.nlm.nih.gov/16480284 DMLRUVA DI DMLRUVA DMLRUVA DN HDS-029 DMLRUVA MI TT0JESD DMLRUVA MN Erbb4 tyrosine kinase receptor (Erbb-4) DMLRUVA MT DTT DMLRUVA MA Inhibitor DMLRUVA RN Tyrosine kinase inhibitors. 19. 6-Alkynamides of 4-anilinoquinazolines and 4-anilinopyrido[3,4-d]pyrimidines as irreversible inhibitors of the erbB... J Med Chem. 2006 Feb 23;49(4):1475-85. DMLRUVA RU https://pubmed.ncbi.nlm.nih.gov/16480284 DMY4QE6 DI DMY4QE6 DMY4QE6 DN H-D-Tca-c[Cys-Tyr-D-Trp-Arg-Thr-Pen]-Thr-NH2 DMY4QE6 MI TT27RFC DMY4QE6 MN Opioid receptor delta (OPRD1) DMY4QE6 MT DTT DMY4QE6 MA Inhibitor DMY4QE6 RN Opiate aromatic pharmacophore structure-activity relationships in CTAP analogues determined by topographical bias, two-dimensional NMR, and biologi... J Med Chem. 2000 Feb 24;43(4):569-80. DMY4QE6 RU https://pubmed.ncbi.nlm.nih.gov/10691683 DMY4QE6 DI DMY4QE6 DMY4QE6 DN H-D-Tca-c[Cys-Tyr-D-Trp-Arg-Thr-Pen]-Thr-NH2 DMY4QE6 MI TTKWM86 DMY4QE6 MN Opioid receptor mu (MOP) DMY4QE6 MT DTT DMY4QE6 MA Inhibitor DMY4QE6 RN Opiate aromatic pharmacophore structure-activity relationships in CTAP analogues determined by topographical bias, two-dimensional NMR, and biologi... J Med Chem. 2000 Feb 24;43(4):569-80. DMY4QE6 RU https://pubmed.ncbi.nlm.nih.gov/10691683 DM8GC36 DI DM8GC36 DM8GC36 DN H-D-Tic-c[Cys-Tyr-D-Trp-Arg-Thr-Pen]-Thr-NH2 DM8GC36 MI TT27RFC DM8GC36 MN Opioid receptor delta (OPRD1) DM8GC36 MT DTT DM8GC36 MA Inhibitor DM8GC36 RN Opiate aromatic pharmacophore structure-activity relationships in CTAP analogues determined by topographical bias, two-dimensional NMR, and biologi... J Med Chem. 2000 Feb 24;43(4):569-80. DM8GC36 RU https://pubmed.ncbi.nlm.nih.gov/10691683 DM8GC36 DI DM8GC36 DM8GC36 DN H-D-Tic-c[Cys-Tyr-D-Trp-Arg-Thr-Pen]-Thr-NH2 DM8GC36 MI TTKWM86 DM8GC36 MN Opioid receptor mu (MOP) DM8GC36 MT DTT DM8GC36 MA Inhibitor DM8GC36 RN Opiate aromatic pharmacophore structure-activity relationships in CTAP analogues determined by topographical bias, two-dimensional NMR, and biologi... J Med Chem. 2000 Feb 24;43(4):569-80. DM8GC36 RU https://pubmed.ncbi.nlm.nih.gov/10691683 DMNAE6J DI DMNAE6J DMNAE6J DN H-D-Trp-c[Cys-Tyr-D-Trp-Arg-Thr-Pen]-Thr-NH2 DMNAE6J MI TT27RFC DMNAE6J MN Opioid receptor delta (OPRD1) DMNAE6J MT DTT DMNAE6J MA Inhibitor DMNAE6J RN Opiate aromatic pharmacophore structure-activity relationships in CTAP analogues determined by topographical bias, two-dimensional NMR, and biologi... J Med Chem. 2000 Feb 24;43(4):569-80. DMNAE6J RU https://pubmed.ncbi.nlm.nih.gov/10691683 DMNAE6J DI DMNAE6J DMNAE6J DN H-D-Trp-c[Cys-Tyr-D-Trp-Arg-Thr-Pen]-Thr-NH2 DMNAE6J MI TTKWM86 DMNAE6J MN Opioid receptor mu (MOP) DMNAE6J MT DTT DMNAE6J MA Inhibitor DMNAE6J RN Opiate aromatic pharmacophore structure-activity relationships in CTAP analogues determined by topographical bias, two-dimensional NMR, and biologi... J Med Chem. 2000 Feb 24;43(4):569-80. DMNAE6J RU https://pubmed.ncbi.nlm.nih.gov/10691683 DM9I5Y0 DI DM9I5Y0 DM9I5Y0 DN Heberkinasa DM9I5Y0 MI TT2VCLI DM9I5Y0 MN Streptococcus Streptokinase (Stre-coc skc) DM9I5Y0 MT DTT DM9I5Y0 MA Modulator DM9I5Y0 RN Biological Activity Analysis of Native and Recombinant Streptokinase Using Clot Lysis and Chromogenic Substrate Assay DM9I5Y0 RU https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3813160 DMZ4A0R DI DMZ4A0R DMZ4A0R DN Hebervis DMZ4A0R MI TTED8JB DMZ4A0R MN Epidermal growth factor (EGF) DMZ4A0R MT DTT DMZ4A0R MA Modulator DMZ4A0R RN Leadership in BioBusiness. Dr Gurinder S Shahi. Page(36). DMZ4A0R RU https://books.google.com.hk/books?id=6qF0AgAAQBAJ&pg=PA36&lpg=PA36&dq=Hebervis++++Epidermal+growth+factor&source=bl&ots=RD745hdy84&sig=5Z2dTG5PlEIIoiJHRtoqvbq5ny8&hl=zh-CN&sa=X&ved=0CB4Q6AEwAWoVChMI6tqlvJDCyAIVUZGOCh1qkgCl#v=onepage&q=Hebervis%20%20%20%20Epidermal%20growth%20factor&f=false DMQPCDG DI DMQPCDG DMQPCDG DN Helenalin-2-methylbutyrate DMQPCDG MI TTSXVID DMQPCDG MN Nuclear factor NF-kappa-B (NFKB) DMQPCDG MT DTT DMQPCDG MA Inhibitor DMQPCDG RN Development of a structural model for NF-kappaB inhibition of sesquiterpene lactones using self-organizing neural networks. J Med Chem. 2006 Apr 6;49(7):2241-52. DMQPCDG RU https://pubmed.ncbi.nlm.nih.gov/16570920 DMPOALD DI DMPOALD DMPOALD DN HELENALINMETHACRYLATE DMPOALD MI TTSXVID DMPOALD MN Nuclear factor NF-kappa-B (NFKB) DMPOALD MT DTT DMPOALD MA Inhibitor DMPOALD RN Development of a structural model for NF-kappaB inhibition of sesquiterpene lactones using self-organizing neural networks. J Med Chem. 2006 Apr 6;49(7):2241-52. DMPOALD RU https://pubmed.ncbi.nlm.nih.gov/16570920 DM5MOLY DI DM5MOLY DM5MOLY DN HELENAQUINONE DM5MOLY MI TT9V5JH DM5MOLY MN Phospholipase A2 (PLA2G1B) DM5MOLY MT DTT DM5MOLY MA Inhibitor DM5MOLY RN New bioactive halenaquinone derivatives from South Pacific marine sponges of the genus Xestospongia. Bioorg Med Chem. 2010 Aug 15;18(16):6006-11. DM5MOLY RU https://pubmed.ncbi.nlm.nih.gov/20634081 DMIUABO DI DMIUABO DMIUABO DN helodermin DMIUABO MI TT4O5P0 DMIUABO MN Helodermin-preferring VIP receptor (VIPR2) DMIUABO MT DTT DMIUABO MA Agonist DMIUABO RN Analogues of VIP, helodermin, and PACAP discriminate between rat and human VIP1 and VIP2 receptors. Ann N Y Acad Sci. 1998 Dec 11;865:247-52. DMIUABO RU https://pubmed.ncbi.nlm.nih.gov/9928018 DMIUABO DI DMIUABO DMIUABO DN helodermin DMIUABO MI TTCL30I DMIUABO MN Vasoactive intestinal polypeptide receptor 1 (VIPR1) DMIUABO MT DTT DMIUABO MA Agonist DMIUABO RN Stable expression of the recombinant human VIP1 receptor in clonal Chinese hamster ovary cells: pharmacological, functional and molecular properties. Eur J Pharmacol. 1996 Apr 29;302(1-3):207-14. DMIUABO RU https://pubmed.ncbi.nlm.nih.gov/8791009 DMVK36Q DI DMVK36Q DMVK36Q DN Hematoporphyrin DMVK36Q MI DTI7UX6 DMVK36Q MN Breast cancer resistance protein (ABCG2) DMVK36Q MT DTP DMVK36Q MA Substrate DMVK36Q RN Cellular phototoxicity evoked through the inhibition of human ABC transporter ABCG2 by cyclin-dependent kinase inhibitors in vitro. Pharm Res. 2009 Feb;26(2):449-58. DMVK36Q RU http://www.ncbi.nlm.nih.gov/pubmed/18841444 DMGC287 DI DMGC287 DMGC287 DN Heme DMGC287 MI TTXV4FI DMGC287 MN Albendazole monooxygenase (CYP3A4) DMGC287 MT DTT DMGC287 MA Inhibitor DMGC287 RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DMGC287 RU https://pubmed.ncbi.nlm.nih.gov/10592235 DMGC287 DI DMGC287 DMGC287 DN Heme DMGC287 MI TT2J34L DMGC287 MN Arachidonate 5-lipoxygenase (5-LOX) DMGC287 MT DTT DMGC287 MA Inhibitor DMGC287 RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DMGC287 RU https://pubmed.ncbi.nlm.nih.gov/10592235 DMGC287 DI DMGC287 DMGC287 DN Heme DMGC287 MI TTNAW8S DMGC287 MN Bacterial Flavohemoglobin (Bact hmp) DMGC287 MT DTT DMGC287 MA Inhibitor DMGC287 RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DMGC287 RU https://pubmed.ncbi.nlm.nih.gov/10592235 DMGC287 DI DMGC287 DMGC287 DN Heme DMGC287 MI TTHDSE2 DMGC287 MN Bacterial Fumarate reductase flavoprotein (Bact frdA) DMGC287 MT DTT DMGC287 MA Inhibitor DMGC287 RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DMGC287 RU https://pubmed.ncbi.nlm.nih.gov/10592235 DMGC287 DI DMGC287 DMGC287 DN Heme DMGC287 MI TTVZJ7G DMGC287 MN Cystathionine beta-synthase (CBS) DMGC287 MT DTT DMGC287 MA Inhibitor DMGC287 RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DMGC287 RU https://pubmed.ncbi.nlm.nih.gov/10592235 DMGC287 DI DMGC287 DMGC287 DN Heme DMGC287 MI TTI6V2A DMGC287 MN Heme oxygenase 1 (HMOX1) DMGC287 MT DTT DMGC287 MA Inhibitor DMGC287 RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DMGC287 RU https://pubmed.ncbi.nlm.nih.gov/10592235 DMGC287 DI DMGC287 DMGC287 DN Heme DMGC287 MI TTQO71U DMGC287 MN Hemoglobin (HB) DMGC287 MT DTT DMGC287 MA Inhibitor DMGC287 RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DMGC287 RU https://pubmed.ncbi.nlm.nih.gov/10592235 DMGC287 DI DMGC287 DMGC287 DN Heme DMGC287 MI TTBK0PU DMGC287 MN Mycobacterium Cytochrome p450 121 (MycB cyp121) DMGC287 MT DTT DMGC287 MA Inhibitor DMGC287 RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DMGC287 RU https://pubmed.ncbi.nlm.nih.gov/10592235 DMGC287 DI DMGC287 DMGC287 DN Heme DMGC287 MI TTZUFI5 DMGC287 MN Nitric-oxide synthase brain (NOS1) DMGC287 MT DTT DMGC287 MA Inhibitor DMGC287 RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DMGC287 RU https://pubmed.ncbi.nlm.nih.gov/10592235 DMGC287 DI DMGC287 DMGC287 DN Heme DMGC287 MI TTCM4B3 DMGC287 MN Nitric-oxide synthase endothelial (NOS3) DMGC287 MT DTT DMGC287 MA Inhibitor DMGC287 RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DMGC287 RU https://pubmed.ncbi.nlm.nih.gov/10592235 DMGC287 DI DMGC287 DMGC287 DN Heme DMGC287 MI TTF10I9 DMGC287 MN Nitric-oxide synthase inducible (NOS2) DMGC287 MT DTT DMGC287 MA Inhibitor DMGC287 RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DMGC287 RU https://pubmed.ncbi.nlm.nih.gov/10592235 DMGC287 DI DMGC287 DMGC287 DN Heme DMGC287 MI TT8NGED DMGC287 MN Prostaglandin G/H synthase 1 (COX-1) DMGC287 MT DTT DMGC287 MA Inhibitor DMGC287 RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DMGC287 RU https://pubmed.ncbi.nlm.nih.gov/10592235 DMGC287 DI DMGC287 DMGC287 DN Heme DMGC287 MI TTVKILB DMGC287 MN Prostaglandin G/H synthase 2 (COX-2) DMGC287 MT DTT DMGC287 MA Inhibitor DMGC287 RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DMGC287 RU https://pubmed.ncbi.nlm.nih.gov/10592235 DMXP276 DI DMXP276 DMXP276 DN Hemi-Babim DMXP276 MI TT6L509 DMXP276 MN Coagulation factor IIa (F2) DMXP276 MT DTT DMXP276 MA Inhibitor DMXP276 RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DMXP276 RU https://pubmed.ncbi.nlm.nih.gov/10592235 DMF7X31 DI DMF7X31 DMF7X31 DN Hemoparatide DMF7X31 MI TTEPJL5 DMF7X31 MN Parathyroid hormone receptor (PTH2R) DMF7X31 MT DTT DMF7X31 MA Modulator DMF7X31 RN The ChEMBL database in 2017. Nucleic Acids Res. 2017 Jan 4;45(D1):D945-D954. DMF7X31 RU https://www.ncbi.nlm.nih.gov/pubmed/27899562 DMY16VG DI DMY16VG DMY16VG DN Heparin Pentasaccharide DMY16VG MI TT4QPUL DMY16VG MN Antithrombin-III (ATIII) DMY16VG MT DTT DMY16VG MA Inhibitor DMY16VG RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMY16VG RU https://pubmed.ncbi.nlm.nih.gov/17139284 DM7U491 DI DM7U491 DM7U491 DN Heparin-Cantithrombin III DM7U491 MI TT6L509 DM7U491 MN Coagulation factor IIa (F2) DM7U491 MT DTT DM7U491 MA Inhibitor DM7U491 RN Thrombin inhibitors in acute coronary artery disease. Eur Heart J. 2002 Aug;23(15):1142-4. DM7U491 RU https://pubmed.ncbi.nlm.nih.gov/12127916 DMK846H DI DMK846H DMK846H DN HEPT DMK846H MI TT84ETX DMK846H MN Human immunodeficiency virus Reverse transcriptase (HIV RT) DMK846H MT DTT DMK846H MA Inhibitor DMK846H RN 5-Alkyl-2-[(aryl and alkyloxylcarbonylmethyl)thio]-6-(1-naphthylmethyl) pyrimidin-4(3H)-ones as an unique HIV reverse transcriptase inhibitors of S... Bioorg Med Chem Lett. 2004 Jun 21;14(12):3173-6. DMK846H RU https://pubmed.ncbi.nlm.nih.gov/15149669 DMV4GDI DI DMV4GDI DMV4GDI DN Heptane-1,2,3-Triol DMV4GDI MI TTH0KSX DMV4GDI MN Rhodopsin (RHO) DMV4GDI MT DTT DMV4GDI MA Inhibitor DMV4GDI RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMV4GDI RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMCFTB8 DI DMCFTB8 DMCFTB8 DN Heptane-2,3-dione DMCFTB8 MI TTMF541 DMCFTB8 MN Liver carboxylesterase (CES1) DMCFTB8 MT DTT DMCFTB8 MA Inhibitor DMCFTB8 RN Identification and characterization of novel benzil (diphenylethane-1,2-dione) analogues as inhibitors of mammalian carboxylesterases. J Med Chem. 2005 Apr 21;48(8):2906-15. DMCFTB8 RU https://pubmed.ncbi.nlm.nih.gov/15828829 DMGEO8N DI DMGEO8N DMGEO8N DN HEPTANOATE DMGEO8N MI TTTQR47 DMGEO8N MN Solute carrier family 22 member 8 (SLC22A8) DMGEO8N MT DTT DMGEO8N MA Inhibitor DMGEO8N RN Structural variation governs substrate specificity for organic anion transporter (OAT) homologs. Potential remote sensing by OAT family members. J Biol Chem. 2007 Aug 17;282(33):23841-53. DMGEO8N RU https://pubmed.ncbi.nlm.nih.gov/17553798 DM4NY9H DI DM4NY9H DM4NY9H DN Heptanoic Acid DM4NY9H MI TT9V5JH DM4NY9H MN Phospholipase A2 (PLA2G1B) DM4NY9H MT DTT DM4NY9H MA Inhibitor DM4NY9H RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DM4NY9H RU https://pubmed.ncbi.nlm.nih.gov/10592235 DMIAQX4 DI DMIAQX4 DMIAQX4 DN Heptulose-2-Phosphate DMIAQX4 MI TTZHY6R DMIAQX4 MN Glycogen phosphorylase muscle form (GP) DMIAQX4 MT DTT DMIAQX4 MA Inhibitor DMIAQX4 RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMIAQX4 RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMKF762 DI DMKF762 DMKF762 DN Heptyl 1-Thiohexopyranoside DMKF762 MI TTH0KSX DMKF762 MN Rhodopsin (RHO) DMKF762 MT DTT DMKF762 MA Inhibitor DMKF762 RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DMKF762 RU https://pubmed.ncbi.nlm.nih.gov/10592235 DMPQBN0 DI DMPQBN0 DMPQBN0 DN Heptyl-Beta-D-Glucopyranoside DMPQBN0 MI TTMW94E DMPQBN0 MN FK506-binding protein 1A (FKBP1A) DMPQBN0 MT DTT DMPQBN0 MA Inhibitor DMPQBN0 RN DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Nucleic Acids Res. 2011 Jan;39(Database issue):D1035-41. DMPQBN0 RU https://pubmed.ncbi.nlm.nih.gov/21059682 DMPQBN0 DI DMPQBN0 DMPQBN0 DN Heptyl-Beta-D-Glucopyranoside DMPQBN0 MI TT2JWF6 DMPQBN0 MN Peroxisome proliferator-activated receptor delta (PPARD) DMPQBN0 MT DTT DMPQBN0 MA Inhibitor DMPQBN0 RN DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Nucleic Acids Res. 2011 Jan;39(Database issue):D1035-41. DMPQBN0 RU https://pubmed.ncbi.nlm.nih.gov/21059682 DM1NUO5 DI DM1NUO5 DM1NUO5 DN Heptyl-methyl-prop-2-ynyl-amine hydrochloride DM1NUO5 MI TTGP7BY DM1NUO5 MN Monoamine oxidase type B (MAO-B) DM1NUO5 MT DTT DM1NUO5 MA Inhibitor DM1NUO5 RN Aliphatic propargylamines: potent, selective, irreversible monoamine oxidase B inhibitors. J Med Chem. 1992 Oct 2;35(20):3705-13. DM1NUO5 RU https://pubmed.ncbi.nlm.nih.gov/1433183 DM0VC84 DI DM0VC84 DM0VC84 DN Her2- and PSA-targeted TGX-D1 DM0VC84 MI TTHBTOP DM0VC84 MN PI3-kinase gamma (PIK3CG) DM0VC84 MT DTT DM0VC84 MA Inhibitor DM0VC84 RN Development of a peptide-drug conjugate for prostate cancer therapy. Mol Pharm. 2011 Jun 6;8(3):901-12. DM0VC84 RU https://pubmed.ncbi.nlm.nih.gov/21510670 DM8MD52 DI DM8MD52 DM8MD52 DN HERBACETIN DM8MD52 MI TT50QJ3 DM8MD52 MN Influenza Neuraminidase (Influ NA) DM8MD52 MT DTT DM8MD52 MA Inhibitor DM8MD52 RN Neuraminidase inhibitory activities of flavonols isolated from Rhodiola rosea roots and their in vitro anti-influenza viral activities. Bioorg Med Chem. 2009 Oct 1;17(19):6816-23. DM8MD52 RU https://pubmed.ncbi.nlm.nih.gov/19729316 DMJXBWV DI DMJXBWV DMJXBWV DN HERKINORIN DMJXBWV MI TT27RFC DMJXBWV MN Opioid receptor delta (OPRD1) DMJXBWV MT DTT DMJXBWV MA Inhibitor DMJXBWV RN Herkinorin analogues with differential beta-arrestin-2 interactions. J Med Chem. 2008 Apr 24;51(8):2421-31. DMJXBWV RU https://pubmed.ncbi.nlm.nih.gov/18380425 DMJXBWV DI DMJXBWV DMJXBWV DN HERKINORIN DMJXBWV MI TTQW87Y DMJXBWV MN Opioid receptor kappa (OPRK1) DMJXBWV MT DTT DMJXBWV MA Inhibitor DMJXBWV RN Herkinorin analogues with differential beta-arrestin-2 interactions. J Med Chem. 2008 Apr 24;51(8):2421-31. DMJXBWV RU https://pubmed.ncbi.nlm.nih.gov/18380425 DMJXBWV DI DMJXBWV DMJXBWV DN HERKINORIN DMJXBWV MI TTKWM86 DMJXBWV MN Opioid receptor mu (MOP) DMJXBWV MT DTT DMJXBWV MA Inhibitor DMJXBWV RN Herkinorin analogues with differential beta-arrestin-2 interactions. J Med Chem. 2008 Apr 24;51(8):2421-31. DMJXBWV RU https://pubmed.ncbi.nlm.nih.gov/18380425 DM9UASM DI DM9UASM DM9UASM DN HERNIARIN DM9UASM MI TTUNARX DM9UASM MN Carbonic anhydrase (CA) DM9UASM MT DTT DM9UASM MA Inhibitor DM9UASM RN Deciphering the mechanism of carbonic anhydrase inhibition with coumarins and thiocoumarins. J Med Chem. 2010 Jan 14;53(1):335-44. DM9UASM RU https://pubmed.ncbi.nlm.nih.gov/19911821 DM9UASM DI DM9UASM DM9UASM DN HERNIARIN DM9UASM MI TTHQPL7 DM9UASM MN Carbonic anhydrase I (CA-I) DM9UASM MT DTT DM9UASM MA Inhibitor DM9UASM RN Deciphering the mechanism of carbonic anhydrase inhibition with coumarins and thiocoumarins. J Med Chem. 2010 Jan 14;53(1):335-44. DM9UASM RU https://pubmed.ncbi.nlm.nih.gov/19911821 DM9UASM DI DM9UASM DM9UASM DN HERNIARIN DM9UASM MI TTZHA0O DM9UASM MN Carbonic anhydrase IV (CA-IV) DM9UASM MT DTT DM9UASM MA Inhibitor DM9UASM RN Deciphering the mechanism of carbonic anhydrase inhibition with coumarins and thiocoumarins. J Med Chem. 2010 Jan 14;53(1):335-44. DM9UASM RU https://pubmed.ncbi.nlm.nih.gov/19911821 DM9UASM DI DM9UASM DM9UASM DN HERNIARIN DM9UASM MI TT2LVK8 DM9UASM MN Carbonic anhydrase IX (CA-IX) DM9UASM MT DTT DM9UASM MA Inhibitor DM9UASM RN Deciphering the mechanism of carbonic anhydrase inhibition with coumarins and thiocoumarins. J Med Chem. 2010 Jan 14;53(1):335-44. DM9UASM RU https://pubmed.ncbi.nlm.nih.gov/19911821 DM9UASM DI DM9UASM DM9UASM DN HERNIARIN DM9UASM MI TTCFSPE DM9UASM MN Carbonic anhydrase VI (CA-VI) DM9UASM MT DTT DM9UASM MA Inhibitor DM9UASM RN Deciphering the mechanism of carbonic anhydrase inhibition with coumarins and thiocoumarins. J Med Chem. 2010 Jan 14;53(1):335-44. DM9UASM RU https://pubmed.ncbi.nlm.nih.gov/19911821 DM9UASM DI DM9UASM DM9UASM DN HERNIARIN DM9UASM MI TTSYM0R DM9UASM MN Carbonic anhydrase XII (CA-XII) DM9UASM MT DTT DM9UASM MA Inhibitor DM9UASM RN Deciphering the mechanism of carbonic anhydrase inhibition with coumarins and thiocoumarins. J Med Chem. 2010 Jan 14;53(1):335-44. DM9UASM RU https://pubmed.ncbi.nlm.nih.gov/19911821 DM9UASM DI DM9UASM DM9UASM DN HERNIARIN DM9UASM MI TTEYTKG DM9UASM MN Carbonic anhydrase XIV (CA-XIV) DM9UASM MT DTT DM9UASM MA Inhibitor DM9UASM RN Deciphering the mechanism of carbonic anhydrase inhibition with coumarins and thiocoumarins. J Med Chem. 2010 Jan 14;53(1):335-44. DM9UASM RU https://pubmed.ncbi.nlm.nih.gov/19911821 DM2CK7B DI DM2CK7B DM2CK7B DN HESPERADIN DM2CK7B MI TT9RTBL DM2CK7B MN Aurora B messenger RNA (AURKB mRNA) DM2CK7B MT DTT DM2CK7B MA Inhibitor DM2CK7B RN Discovery of novel and potent thiazoloquinazolines as selective Aurora A and B kinase inhibitors. J Med Chem. 2006 Feb 9;49(3):955-70. DM2CK7B RU https://pubmed.ncbi.nlm.nih.gov/16451062 DMJCHE1 DI DMJCHE1 DMJCHE1 DN Hexadecanal DMJCHE1 MI TTH0KSX DMJCHE1 MN Rhodopsin (RHO) DMJCHE1 MT DTT DMJCHE1 MA Inhibitor DMJCHE1 RN DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Nucleic Acids Res. 2011 Jan;39(Database issue):D1035-41. DMJCHE1 RU https://pubmed.ncbi.nlm.nih.gov/21059682 DMWUXDZ DI DMWUXDZ DMWUXDZ DN Hexadecanoic acid DMWUXDZ MI TTHWMFZ DMWUXDZ MN Fatty acid-binding protein 4 (FABP4) DMWUXDZ MT DTT DMWUXDZ MA Inhibitor DMWUXDZ RN Discovery of inhibitors of human adipocyte fatty acid-binding protein, a potential type 2 diabetes target. Bioorg Med Chem Lett. 2004 Sep 6;14(17):4445-8. DMWUXDZ RU https://pubmed.ncbi.nlm.nih.gov/15357969 DMWUXDZ DI DMWUXDZ DMWUXDZ DN Hexadecanoic acid DMWUXDZ MI TTNT2S6 DMWUXDZ MN Fatty acid-binding protein 5 (FABP5) DMWUXDZ MT DTT DMWUXDZ MA Inhibitor DMWUXDZ RN Discovery of inhibitors of human adipocyte fatty acid-binding protein, a potential type 2 diabetes target. Bioorg Med Chem Lett. 2004 Sep 6;14(17):4445-8. DMWUXDZ RU https://pubmed.ncbi.nlm.nih.gov/15357969 DMWUXDZ DI DMWUXDZ DMWUXDZ DN Hexadecanoic acid DMWUXDZ MI TTH0KSX DMWUXDZ MN Rhodopsin (RHO) DMWUXDZ MT DTT DMWUXDZ MA Inhibitor DMWUXDZ RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMWUXDZ RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMNZLD6 DI DMNZLD6 DMNZLD6 DN Hexahydro-cyclopenta[b]pyrrol-(2Z)-ylideneamine DMNZLD6 MI TTZUFI5 DMNZLD6 MN Nitric-oxide synthase brain (NOS1) DMNZLD6 MT DTT DMNZLD6 MA Inhibitor DMNZLD6 RN Evaluation of pyrrolidin-2-imines and 1,3-thiazolidin-2-imines as inhibitors of nitric oxide synthase. Bioorg Med Chem Lett. 2004 Sep 6;14(17):4539-44. DMNZLD6 RU https://pubmed.ncbi.nlm.nih.gov/15357988 DMG0UVT DI DMG0UVT DMG0UVT DN Hexahydro-cyclopenta[c]pyrrol-(1Z)-ylideneamine DMG0UVT MI TTZUFI5 DMG0UVT MN Nitric-oxide synthase brain (NOS1) DMG0UVT MT DTT DMG0UVT MA Inhibitor DMG0UVT RN Evaluation of pyrrolidin-2-imines and 1,3-thiazolidin-2-imines as inhibitors of nitric oxide synthase. Bioorg Med Chem Lett. 2004 Sep 6;14(17):4539-44. DMG0UVT RU https://pubmed.ncbi.nlm.nih.gov/15357988 DMG0UVT DI DMG0UVT DMG0UVT DN Hexahydro-cyclopenta[c]pyrrol-(1Z)-ylideneamine DMG0UVT MI TTCM4B3 DMG0UVT MN Nitric-oxide synthase endothelial (NOS3) DMG0UVT MT DTT DMG0UVT MA Inhibitor DMG0UVT RN Evaluation of pyrrolidin-2-imines and 1,3-thiazolidin-2-imines as inhibitors of nitric oxide synthase. Bioorg Med Chem Lett. 2004 Sep 6;14(17):4539-44. DMG0UVT RU https://pubmed.ncbi.nlm.nih.gov/15357988 DMG0UVT DI DMG0UVT DMG0UVT DN Hexahydro-cyclopenta[c]pyrrol-(1Z)-ylideneamine DMG0UVT MI TTF10I9 DMG0UVT MN Nitric-oxide synthase inducible (NOS2) DMG0UVT MT DTT DMG0UVT MA Inhibitor DMG0UVT RN Evaluation of pyrrolidin-2-imines and 1,3-thiazolidin-2-imines as inhibitors of nitric oxide synthase. Bioorg Med Chem Lett. 2004 Sep 6;14(17):4539-44. DMG0UVT RU https://pubmed.ncbi.nlm.nih.gov/15357988 DMH25OD DI DMH25OD DMH25OD DN hexahydrodifenidol DMH25OD MI TTOXS3C DMH25OD MN Muscarinic acetylcholine receptor (CHRM) DMH25OD MT DTT DMH25OD MA Antagonist DMH25OD RN Antagonist binding properties of five cloned muscarinic receptors expressed in CHO-K1 cells. Mol Pharmacol. 1989 Apr;35(4):469-76. DMH25OD RU https://pubmed.ncbi.nlm.nih.gov/2704370 DMH25OD DI DMH25OD DMH25OD DN hexahydrodifenidol DMH25OD MI TTQ13Z5 DMH25OD MN Muscarinic acetylcholine receptor M3 (CHRM3) DMH25OD MT DTT DMH25OD MA Antagonist DMH25OD RN Antagonist binding properties of five cloned muscarinic receptors expressed in CHO-K1 cells. Mol Pharmacol. 1989 Apr;35(4):469-76. DMH25OD RU https://pubmed.ncbi.nlm.nih.gov/2704370 DMIB3J2 DI DMIB3J2 DMIB3J2 DN Hexahydro-pyrrolizin-(3E)-ylideneamine DMIB3J2 MI TTZUFI5 DMIB3J2 MN Nitric-oxide synthase brain (NOS1) DMIB3J2 MT DTT DMIB3J2 MA Inhibitor DMIB3J2 RN Evaluation of pyrrolidin-2-imines and 1,3-thiazolidin-2-imines as inhibitors of nitric oxide synthase. Bioorg Med Chem Lett. 2004 Sep 6;14(17):4539-44. DMIB3J2 RU https://pubmed.ncbi.nlm.nih.gov/15357988 DM6UAV7 DI DM6UAV7 DM6UAV7 DN hexahydrosiladifenidol DM6UAV7 MI TTOXS3C DM6UAV7 MN Muscarinic acetylcholine receptor (CHRM) DM6UAV7 MT DTT DM6UAV7 MA Antagonist DM6UAV7 RN Antagonist binding properties of five cloned muscarinic receptors expressed in CHO-K1 cells. Mol Pharmacol. 1989 Apr;35(4):469-76. DM6UAV7 RU https://pubmed.ncbi.nlm.nih.gov/2704370 DM6UAV7 DI DM6UAV7 DM6UAV7 DN hexahydrosiladifenidol DM6UAV7 MI TTQ13Z5 DM6UAV7 MN Muscarinic acetylcholine receptor M3 (CHRM3) DM6UAV7 MT DTT DM6UAV7 MA Antagonist DM6UAV7 RN Antagonist binding properties of five cloned muscarinic receptors expressed in CHO-K1 cells. Mol Pharmacol. 1989 Apr;35(4):469-76. DM6UAV7 RU https://pubmed.ncbi.nlm.nih.gov/2704370 DMSHF0K DI DMSHF0K DMSHF0K DN Hexane-1,6-diamine DMSHF0K MI TTUNARX DMSHF0K MN Carbonic anhydrase (CA) DMSHF0K MT DTT DMSHF0K MA Inhibitor DMSHF0K RN Polyamines inhibit carbonic anhydrases by anchoring to the zinc-coordinated water molecule. J Med Chem. 2010 Aug 12;53(15):5511-22. DMSHF0K RU https://pubmed.ncbi.nlm.nih.gov/20590092 DMSHF0K DI DMSHF0K DMSHF0K DN Hexane-1,6-diamine DMSHF0K MI TTHQPL7 DMSHF0K MN Carbonic anhydrase I (CA-I) DMSHF0K MT DTT DMSHF0K MA Inhibitor DMSHF0K RN Polyamines inhibit carbonic anhydrases by anchoring to the zinc-coordinated water molecule. J Med Chem. 2010 Aug 12;53(15):5511-22. DMSHF0K RU https://pubmed.ncbi.nlm.nih.gov/20590092 DMSHF0K DI DMSHF0K DMSHF0K DN Hexane-1,6-diamine DMSHF0K MI TTZHA0O DMSHF0K MN Carbonic anhydrase IV (CA-IV) DMSHF0K MT DTT DMSHF0K MA Inhibitor DMSHF0K RN Polyamines inhibit carbonic anhydrases by anchoring to the zinc-coordinated water molecule. J Med Chem. 2010 Aug 12;53(15):5511-22. DMSHF0K RU https://pubmed.ncbi.nlm.nih.gov/20590092 DMSHF0K DI DMSHF0K DMSHF0K DN Hexane-1,6-diamine DMSHF0K MI TT2LVK8 DMSHF0K MN Carbonic anhydrase IX (CA-IX) DMSHF0K MT DTT DMSHF0K MA Inhibitor DMSHF0K RN Polyamines inhibit carbonic anhydrases by anchoring to the zinc-coordinated water molecule. J Med Chem. 2010 Aug 12;53(15):5511-22. DMSHF0K RU https://pubmed.ncbi.nlm.nih.gov/20590092 DMSHF0K DI DMSHF0K DMSHF0K DN Hexane-1,6-diamine DMSHF0K MI TTCFSPE DMSHF0K MN Carbonic anhydrase VI (CA-VI) DMSHF0K MT DTT DMSHF0K MA Inhibitor DMSHF0K RN Polyamines inhibit carbonic anhydrases by anchoring to the zinc-coordinated water molecule. J Med Chem. 2010 Aug 12;53(15):5511-22. DMSHF0K RU https://pubmed.ncbi.nlm.nih.gov/20590092 DMSHF0K DI DMSHF0K DMSHF0K DN Hexane-1,6-diamine DMSHF0K MI TTSYM0R DMSHF0K MN Carbonic anhydrase XII (CA-XII) DMSHF0K MT DTT DMSHF0K MA Inhibitor DMSHF0K RN Polyamines inhibit carbonic anhydrases by anchoring to the zinc-coordinated water molecule. J Med Chem. 2010 Aug 12;53(15):5511-22. DMSHF0K RU https://pubmed.ncbi.nlm.nih.gov/20590092 DMSHF0K DI DMSHF0K DMSHF0K DN Hexane-1,6-diamine DMSHF0K MI TTEYTKG DMSHF0K MN Carbonic anhydrase XIV (CA-XIV) DMSHF0K MT DTT DMSHF0K MA Inhibitor DMSHF0K RN Polyamines inhibit carbonic anhydrases by anchoring to the zinc-coordinated water molecule. J Med Chem. 2010 Aug 12;53(15):5511-22. DMSHF0K RU https://pubmed.ncbi.nlm.nih.gov/20590092 DMWAPGI DI DMWAPGI DMWAPGI DN Hexane-1,6-Diol DMWAPGI MI TTYRL6O DMWAPGI MN Glucocorticoid receptor (NR3C1) DMWAPGI MT DTT DMWAPGI MA Inhibitor DMWAPGI RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMWAPGI RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMWAPGI DI DMWAPGI DMWAPGI DN Hexane-1,6-Diol DMWAPGI MI TT9V5JH DMWAPGI MN Phospholipase A2 (PLA2G1B) DMWAPGI MT DTT DMWAPGI MA Inhibitor DMWAPGI RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMWAPGI RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMJOZYG DI DMJOZYG DMJOZYG DN Hexanoic Acid (2,6-diphenylpyrimidin-4-yl)amide DMJOZYG MI TTK25J1 DMJOZYG MN Adenosine A1 receptor (ADORA1) DMJOZYG MT DTT DMJOZYG MA Inhibitor DMJOZYG RN 2,4,6-trisubstituted pyrimidines as a new class of selective adenosine A1 receptor antagonists. J Med Chem. 2004 Dec 16;47(26):6529-40. DMJOZYG RU https://pubmed.ncbi.nlm.nih.gov/15588088 DMJOZYG DI DMJOZYG DMJOZYG DN Hexanoic Acid (2,6-diphenylpyrimidin-4-yl)amide DMJOZYG MI TTJFY5U DMJOZYG MN Adenosine A3 receptor (ADORA3) DMJOZYG MT DTT DMJOZYG MA Inhibitor DMJOZYG RN 2,4,6-trisubstituted pyrimidines as a new class of selective adenosine A1 receptor antagonists. J Med Chem. 2004 Dec 16;47(26):6529-40. DMJOZYG RU https://pubmed.ncbi.nlm.nih.gov/15588088 DM4U0L1 DI DM4U0L1 DM4U0L1 DN Hexanoic acid 2,5-diphenyl-thiazol-4-yl ester DM4U0L1 MI TT2J34L DM4U0L1 MN Arachidonate 5-lipoxygenase (5-LOX) DM4U0L1 MT DTT DM4U0L1 MA Inhibitor DM4U0L1 RN 4-hydroxythiazole inhibitors of 5-lipoxygenase. J Med Chem. 1991 Jul;34(7):2158-65. DM4U0L1 RU https://pubmed.ncbi.nlm.nih.gov/2066989 DM0HS7L DI DM0HS7L DM0HS7L DN hexocyclium DM0HS7L MI TTZ9SOR DM0HS7L MN Muscarinic acetylcholine receptor M1 (CHRM1) DM0HS7L MT DTT DM0HS7L MA Modulator DM0HS7L RN Hexocyclium derivatives with a high selectivity for smooth muscle muscarinic receptors. Br J Pharmacol. 1990 May;100(1):150-2. DM0HS7L RU https://www.ncbi.nlm.nih.gov/pubmed/2372655 DMHTWN9 DI DMHTWN9 DMHTWN9 DN Hex-RYYRIK-NH2 DMHTWN9 MI TTNT7K8 DMHTWN9 MN Nociceptin receptor (OPRL1) DMHTWN9 MT DTT DMHTWN9 MA Inhibitor DMHTWN9 RN Designed modification of partial agonist of ORL1 nociceptin receptor for conversion into highly potent antagonist. Bioorg Med Chem. 2008 Mar 1;16(5):2635-44. DMHTWN9 RU https://pubmed.ncbi.nlm.nih.gov/18068993 DMBC8KM DI DMBC8KM DMBC8KM DN Hexylacrolein DMBC8KM MI DE8RYV5 DMBC8KM MN NADPH:quinone reductase (CRYZ) DMBC8KM MT DME DMBC8KM MA Metabolism DMBC8KM RN Kinetic and structural evidence of the alkenal/one reductase specificity of human crystallin. Cell Mol Life Sci. 2011 Mar;68(6):1065-77. DMBC8KM RU https://www.ncbi.nlm.nih.gov/pubmed/?term=20835842 DM3YFG9 DI DM3YFG9 DM3YFG9 DN Hexylcarbamoyl fluorouracil DM3YFG9 MI TTNHMO8 DM3YFG9 MN COVID-19 papain-like proteinase (PL-PRO) DM3YFG9 MT DTT DM3YFG9 MA Inhibitor DM3YFG9 RN Structure of Mpro from COVID-19 virus and discovery of its inhibitors. Nature. 2020 Apr 9. DM3YFG9 RU https://pubmed.ncbi.nlm.nih.gov/32272481 DM9EW7V DI DM9EW7V DM9EW7V DN Hexyl-trimethyl-ammonium DM9EW7V MI TT1RS9F DM9EW7V MN Acetylcholinesterase (AChE) DM9EW7V MT DTT DM9EW7V MA Inhibitor DM9EW7V RN Structure-based alignment and comparative molecular field analysis of acetylcholinesterase inhibitors. J Med Chem. 1996 Dec 20;39(26):5064-71. DM9EW7V RU https://pubmed.ncbi.nlm.nih.gov/8978837 DMM4JCA DI DMM4JCA DMM4JCA DN HG-1051 DMM4JCA MI TTPW9LJ DMM4JCA MN Co-stimulatory molecule 4-1BB (CD137) DMM4JCA MT DTT DMM4JCA MA Modulator DMM4JCA RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1878). DMM4JCA RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1878 DM8FD3Z DI DM8FD3Z DM8FD3Z DN HG-9-91-01 DM8FD3Z MI TT1H6LC DM8FD3Z MN Salt-inducible kinase 1 (SIK1) DM8FD3Z MT DTT DM8FD3Z MA Inhibitor DM8FD3Z RN Phosphorylation of CRTC3 by the salt-inducible kinases controls the interconversion of classically activated and regulatory macrophages. Proc Natl Acad Sci U S A. 2012 Oct 16;109(42):16986-91. DM8FD3Z RU https://pubmed.ncbi.nlm.nih.gov/23033494 DM8FD3Z DI DM8FD3Z DM8FD3Z DN HG-9-91-01 DM8FD3Z MI TTCUGZR DM8FD3Z MN Salt-inducible kinase 2 (SIK2) DM8FD3Z MT DTT DM8FD3Z MA Inhibitor DM8FD3Z RN Phosphorylation of CRTC3 by the salt-inducible kinases controls the interconversion of classically activated and regulatory macrophages. Proc Natl Acad Sci U S A. 2012 Oct 16;109(42):16986-91. DM8FD3Z RU https://pubmed.ncbi.nlm.nih.gov/23033494 DM8FD3Z DI DM8FD3Z DM8FD3Z DN HG-9-91-01 DM8FD3Z MI TTW6L4V DM8FD3Z MN SIK family kinase 3 (SIK3) DM8FD3Z MT DTT DM8FD3Z MA Inhibitor DM8FD3Z RN Phosphorylation of CRTC3 by the salt-inducible kinases controls the interconversion of classically activated and regulatory macrophages. Proc Natl Acad Sci U S A. 2012 Oct 16;109(42):16986-91. DM8FD3Z RU https://pubmed.ncbi.nlm.nih.gov/23033494 DMOIPYD DI DMOIPYD DMOIPYD DN hGCGR antagonist DMOIPYD MI TT9O6WS DMOIPYD MN Glucagon receptor (GCGR) DMOIPYD MT DTT DMOIPYD MA Antagonist DMOIPYD RN A novel glucagon receptor antagonist inhibits glucagon-mediated biological effects. Diabetes. 2004 Dec;53(12):3267-73. DMOIPYD RU https://pubmed.ncbi.nlm.nih.gov/15561959 DMX2TGD DI DMX2TGD DMX2TGD DN H-Gly-D-dmP-Glu-OH DMX2TGD MI TTLD29N DMX2TGD MN Glutamate receptor ionotropic NMDA 1 (NMDAR1) DMX2TGD MT DTT DMX2TGD MA Inhibitor DMX2TGD RN The neuroprotective activity of GPE tripeptide analogues does not correlate with glutamate receptor binding affinity. Bioorg Med Chem Lett. 2006 Jul 1;16(13):3396-400. DMX2TGD RU https://pubmed.ncbi.nlm.nih.gov/16650992 DMX2TGD DI DMX2TGD DMX2TGD DN H-Gly-D-dmP-Glu-OH DMX2TGD MI TTKJEMQ DMX2TGD MN Glutamate receptor ionotropic NMDA 2A (NMDAR2A) DMX2TGD MT DTT DMX2TGD MA Inhibitor DMX2TGD RN The neuroprotective activity of GPE tripeptide analogues does not correlate with glutamate receptor binding affinity. Bioorg Med Chem Lett. 2006 Jul 1;16(13):3396-400. DMX2TGD RU https://pubmed.ncbi.nlm.nih.gov/16650992 DMX2TGD DI DMX2TGD DMX2TGD DN H-Gly-D-dmP-Glu-OH DMX2TGD MI TTN9D8E DMX2TGD MN Glutamate receptor ionotropic NMDA 2B (NMDAR2B) DMX2TGD MT DTT DMX2TGD MA Inhibitor DMX2TGD RN The neuroprotective activity of GPE tripeptide analogues does not correlate with glutamate receptor binding affinity. Bioorg Med Chem Lett. 2006 Jul 1;16(13):3396-400. DMX2TGD RU https://pubmed.ncbi.nlm.nih.gov/16650992 DMOYQPM DI DMOYQPM DMOYQPM DN H-Gly-dmP-Glu-OH DMOYQPM MI TTLD29N DMOYQPM MN Glutamate receptor ionotropic NMDA 1 (NMDAR1) DMOYQPM MT DTT DMOYQPM MA Inhibitor DMOYQPM RN The neuroprotective activity of GPE tripeptide analogues does not correlate with glutamate receptor binding affinity. Bioorg Med Chem Lett. 2006 Jul 1;16(13):3396-400. DMOYQPM RU https://pubmed.ncbi.nlm.nih.gov/16650992 DMOYQPM DI DMOYQPM DMOYQPM DN H-Gly-dmP-Glu-OH DMOYQPM MI TTKJEMQ DMOYQPM MN Glutamate receptor ionotropic NMDA 2A (NMDAR2A) DMOYQPM MT DTT DMOYQPM MA Inhibitor DMOYQPM RN The neuroprotective activity of GPE tripeptide analogues does not correlate with glutamate receptor binding affinity. Bioorg Med Chem Lett. 2006 Jul 1;16(13):3396-400. DMOYQPM RU https://pubmed.ncbi.nlm.nih.gov/16650992 DMOYQPM DI DMOYQPM DMOYQPM DN H-Gly-dmP-Glu-OH DMOYQPM MI TTN9D8E DMOYQPM MN Glutamate receptor ionotropic NMDA 2B (NMDAR2B) DMOYQPM MT DTT DMOYQPM MA Inhibitor DMOYQPM RN The neuroprotective activity of GPE tripeptide analogues does not correlate with glutamate receptor binding affinity. Bioorg Med Chem Lett. 2006 Jul 1;16(13):3396-400. DMOYQPM RU https://pubmed.ncbi.nlm.nih.gov/16650992 DMCKAWY DI DMCKAWY DMCKAWY DN HI-172 DMCKAWY MI TT84ETX DMCKAWY MN Human immunodeficiency virus Reverse transcriptase (HIV RT) DMCKAWY MT DTT DMCKAWY MA Inhibitor DMCKAWY RN Rational design of N-[2-(2,5-dimethoxyphenylethyl)]-N'-[2-(5-bromopyridyl)]-thiourea (HI-236) as a potent non-nucleoside inhibitor of drug-resistan... Bioorg Med Chem Lett. 1999 Jun 7;9(11):1593-8. DMCKAWY RU https://pubmed.ncbi.nlm.nih.gov/10386942 DM3R4ZF DI DM3R4ZF DM3R4ZF DN HI-236 DM3R4ZF MI TT84ETX DM3R4ZF MN Human immunodeficiency virus Reverse transcriptase (HIV RT) DM3R4ZF MT DTT DM3R4ZF MA Inhibitor DM3R4ZF RN Antioxidant function of phenethyl-5-bromo-pyridyl thiourea compounds with potent anti-HIV activity. Bioorg Med Chem Lett. 2000 Jan 3;10(1):87-90. DM3R4ZF RU https://pubmed.ncbi.nlm.nih.gov/10636251 DMQK5RM DI DMQK5RM DMQK5RM DN HI-240 DMQK5RM MI TT84ETX DMQK5RM MN Human immunodeficiency virus Reverse transcriptase (HIV RT) DMQK5RM MT DTT DMQK5RM MA Inhibitor DMQK5RM RN N'-[2-(2-thiophene)ethyl]-N'-[2-(5-bromopyridyl)] thiourea as a potent inhibitor of NNI-resistant and multidrug-resistant human immunodeficiency vi... Bioorg Med Chem Lett. 1999 Dec 20;9(24):3411-6. DMQK5RM RU https://pubmed.ncbi.nlm.nih.gov/10617082 DMTKCW6 DI DMTKCW6 DMTKCW6 DN HI-241 DMTKCW6 MI TT84ETX DMTKCW6 MN Human immunodeficiency virus Reverse transcriptase (HIV RT) DMTKCW6 MT DTT DMTKCW6 MA Inhibitor DMTKCW6 RN Antioxidant function of phenethyl-5-bromo-pyridyl thiourea compounds with potent anti-HIV activity. Bioorg Med Chem Lett. 2000 Jan 3;10(1):87-90. DMTKCW6 RU https://pubmed.ncbi.nlm.nih.gov/10636251 DM0QYLP DI DM0QYLP DM0QYLP DN HI-242 DM0QYLP MI TT84ETX DM0QYLP MN Human immunodeficiency virus Reverse transcriptase (HIV RT) DM0QYLP MT DTT DM0QYLP MA Inhibitor DM0QYLP RN Antioxidant function of phenethyl-5-bromo-pyridyl thiourea compounds with potent anti-HIV activity. Bioorg Med Chem Lett. 2000 Jan 3;10(1):87-90. DM0QYLP RU https://pubmed.ncbi.nlm.nih.gov/10636251 DMG36BD DI DMG36BD DMG36BD DN HI-244 DMG36BD MI TT84ETX DMG36BD MN Human immunodeficiency virus Reverse transcriptase (HIV RT) DMG36BD MT DTT DMG36BD MA Inhibitor DMG36BD RN Anti-HIV activity of aromatic and heterocyclic thiazolyl thiourea compounds. Bioorg Med Chem Lett. 2001 Feb 26;11(4):523-8. DMG36BD RU https://pubmed.ncbi.nlm.nih.gov/11229762 DME4SML DI DME4SML DME4SML DN HI-280 DME4SML MI TT84ETX DME4SML MN Human immunodeficiency virus Reverse transcriptase (HIV RT) DME4SML MT DTT DME4SML MA Inhibitor DME4SML RN Rational design of N-[2-(2,5-dimethoxyphenylethyl)]-N'-[2-(5-bromopyridyl)]-thiourea (HI-236) as a potent non-nucleoside inhibitor of drug-resistan... Bioorg Med Chem Lett. 1999 Jun 7;9(11):1593-8. DME4SML RU https://pubmed.ncbi.nlm.nih.gov/10386942 DM7K0PH DI DM7K0PH DM7K0PH DN HI-281 DM7K0PH MI TT84ETX DM7K0PH MN Human immunodeficiency virus Reverse transcriptase (HIV RT) DM7K0PH MT DTT DM7K0PH MA Inhibitor DM7K0PH RN Rational design of N-[2-(2,5-dimethoxyphenylethyl)]-N'-[2-(5-bromopyridyl)]-thiourea (HI-236) as a potent non-nucleoside inhibitor of drug-resistan... Bioorg Med Chem Lett. 1999 Jun 7;9(11):1593-8. DM7K0PH RU https://pubmed.ncbi.nlm.nih.gov/10386942 DMSUWD8 DI DMSUWD8 DMSUWD8 DN HI-443 DMSUWD8 MI TT84ETX DMSUWD8 MN Human immunodeficiency virus Reverse transcriptase (HIV RT) DMSUWD8 MT DTT DMSUWD8 MA Inhibitor DMSUWD8 RN N'-[2-(2-thiophene)ethyl]-N'-[2-(5-bromopyridyl)] thiourea as a potent inhibitor of NNI-resistant and multidrug-resistant human immunodeficiency vi... Bioorg Med Chem Lett. 1999 Dec 20;9(24):3411-6. DMSUWD8 RU https://pubmed.ncbi.nlm.nih.gov/10617082 DMYP0DE DI DMYP0DE DMYP0DE DN HI-445 DMYP0DE MI TT84ETX DMYP0DE MN Human immunodeficiency virus Reverse transcriptase (HIV RT) DMYP0DE MT DTT DMYP0DE MA Inhibitor DMYP0DE RN Rational design of N-[2-(2,5-dimethoxyphenylethyl)]-N'-[2-(5-bromopyridyl)]-thiourea (HI-236) as a potent non-nucleoside inhibitor of drug-resistan... Bioorg Med Chem Lett. 1999 Jun 7;9(11):1593-8. DMYP0DE RU https://pubmed.ncbi.nlm.nih.gov/10386942 DMD6NZO DI DMD6NZO DMD6NZO DN Hinokinin DMD6NZO MI TTXV4FI DMD6NZO MN Albendazole monooxygenase (CYP3A4) DMD6NZO MT DTT DMD6NZO MA Inhibitor DMD6NZO RN Potent CYP3A4 inhibitory constituents of Piper cubeba. J Nat Prod. 2005 Jan;68(1):64-8. DMD6NZO RU https://pubmed.ncbi.nlm.nih.gov/15679319 DMHL9Y6 DI DMHL9Y6 DMHL9Y6 DN HINOKITIOL DMHL9Y6 MI TTULVH8 DMHL9Y6 MN Tyrosinase (TYR) DMHL9Y6 MT DTT DMHL9Y6 MA Inhibitor DMHL9Y6 RN Structural insights into the hot spot amino acid residues of mushroom tyrosinase for the bindings of thujaplicins. Bioorg Med Chem. 2010 Nov 15;18(22):8112-8. DMHL9Y6 RU https://pubmed.ncbi.nlm.nih.gov/20947360 DM0PV2Y DI DM0PV2Y DM0PV2Y DN Hippuristanol DM0PV2Y MI TTIGYVZ DM0PV2Y MN HUMAN eukaryotic initiation factor-4A (eIF4A) DM0PV2Y MT DTT DM0PV2Y MA Inhibitor DM0PV2Y RN Effects of hippuristanol, an inhibitor of eIF4A, on adult T-cell leukemia. Biochem Pharmacol. 2011 Mar 15;81(6):713-22. DM0PV2Y RU https://pubmed.ncbi.nlm.nih.gov/21219881 DMRJGOP DI DMRJGOP DMRJGOP DN His-DPhe-Arg-Trp DMRJGOP MI TTD0CIQ DMRJGOP MN Melanocortin receptor 4 (MC4R) DMRJGOP MT DTT DMRJGOP MA Inhibitor DMRJGOP RN Squalene-derived flexible linkers for bioactive peptides. Bioorg Med Chem Lett. 2007 Jun 15;17(12):3310-3. DMRJGOP RU https://pubmed.ncbi.nlm.nih.gov/17448660 DMA9YIB DI DMA9YIB DMA9YIB DN histaprodifen DMA9YIB MI TTTIBOJ DMA9YIB MN Histamine H1 receptor (H1R) DMA9YIB MT DTT DMA9YIB MA Agonist DMA9YIB RN Evaluation of histamine H1-, H2-, and H3-receptor ligands at the human histamine H4 receptor: identification of 4-methylhistamine as the first pote... J Pharmacol Exp Ther. 2005 Sep;314(3):1310-21. DMA9YIB RU https://pubmed.ncbi.nlm.nih.gov/15947036 DM7MUJ3 DI DM7MUJ3 DM7MUJ3 DN HITOPK-032 DM7MUJ3 MI TTMY6BZ DM7MUJ3 MN PDZ binding kinase (PBK) DM7MUJ3 MT DTT DM7MUJ3 MA Inhibitor DM7MUJ3 RN PDZ binding kinase (PBK) is a theranostic target for nasopharyngeal carcinoma: driving tumor growth via ROS signaling and correlating with patient survival.Oncotarget. 2016 May 3;7(18):26604-16. DM7MUJ3 RU https://pubmed.ncbi.nlm.nih.gov/27049917 DMNI5FW DI DMNI5FW DMNI5FW DN HJC 0350 DMNI5FW MI TTOS63B DMNI5FW MN Rap guanine nucleotide exchange factor 4 (EPAC2) DMNI5FW MT DTT DMNI5FW MA Inhibitor DMNI5FW RN Identification and characterization of small molecules as potent and specific EPAC2 antagonists. J Med Chem. 2013 Feb 14;56(3):952-62. DMNI5FW RU https://pubmed.ncbi.nlm.nih.gov/23286832 DMWIOCY DI DMWIOCY DMWIOCY DN HJP-272 DMWIOCY MI TTKRD0G DMWIOCY MN Endothelin A receptor (EDNRA) DMWIOCY MT DTT DMWIOCY MA Antagonist DMWIOCY RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 219). DMWIOCY RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=219 DME13RQ DI DME13RQ DME13RQ DN hK2p01 derivative KLK2 inhibitor DME13RQ MI TTJLNAW DME13RQ MN Tissue kallikrein (KLK2) DME13RQ MT DTT DME13RQ MA Inhibitor DME13RQ RN Novel peptide inhibitors of human kallikrein 2. J Biol Chem. 2006 May 5;281(18):12555-60. DME13RQ RU https://pubmed.ncbi.nlm.nih.gov/16527822 DM5LR2B DI DM5LR2B DM5LR2B DN HKI-9924129 DM5LR2B MI TT4ILYC DM5LR2B MN Bacterial Dihydropteroate synthetase (Bact folP) DM5LR2B MT DTT DM5LR2B MA Inhibitor DM5LR2B RN Emerging drugs for bacterial urinary tract infections. Expert Opin Emerg Drugs. 2005 May;10(2):275-98. DM5LR2B RU https://pubmed.ncbi.nlm.nih.gov/15934867 DM5LR2B DI DM5LR2B DM5LR2B DN HKI-9924129 DM5LR2B MI TTGKNB4 DM5LR2B MN Epidermal growth factor receptor (EGFR) DM5LR2B MT DTT DM5LR2B MA Inhibitor DM5LR2B RN Biochemical and cellular effects of c-Src kinase-selective pyrido[2, 3-d]pyrimidine tyrosine kinase inhibitors. Biochem Pharmacol. 2000 Oct 1;60(7):885-98. DM5LR2B RU https://pubmed.ncbi.nlm.nih.gov/10974196 DM5LR2B DI DM5LR2B DM5LR2B DN HKI-9924129 DM5LR2B MI TTRLW2X DM5LR2B MN Fibroblast growth factor receptor 1 (FGFR1) DM5LR2B MT DTT DM5LR2B MA Inhibitor DM5LR2B RN Biochemical and cellular effects of c-Src kinase-selective pyrido[2, 3-d]pyrimidine tyrosine kinase inhibitors. Biochem Pharmacol. 2000 Oct 1;60(7):885-98. DM5LR2B RU https://pubmed.ncbi.nlm.nih.gov/10974196 DM5LR2B DI DM5LR2B DM5LR2B DN HKI-9924129 DM5LR2B MI TTS7G69 DM5LR2B MN Fusion protein Bcr-Abl (Bcr-Abl) DM5LR2B MT DTT DM5LR2B MA Inhibitor DM5LR2B RN Activity of the Bcr-Abl kinase inhibitor PD180970 against clinically relevant Bcr-Abl isoforms that cause resistance to imatinib mesylate (Gleevec, STI571). Cancer Res. 2002 Dec 15;62(24):7149-53. DM5LR2B RU https://pubmed.ncbi.nlm.nih.gov/12499247 DM5LR2B DI DM5LR2B DM5LR2B DN HKI-9924129 DM5LR2B MI TT860QF DM5LR2B MN LCK tyrosine protein kinase (LCK) DM5LR2B MT DTT DM5LR2B MA Inhibitor DM5LR2B RN Biochemical and cellular effects of c-Src kinase-selective pyrido[2, 3-d]pyrimidine tyrosine kinase inhibitors. Biochem Pharmacol. 2000 Oct 1;60(7):885-98. DM5LR2B RU https://pubmed.ncbi.nlm.nih.gov/10974196 DM5LR2B DI DM5LR2B DM5LR2B DN HKI-9924129 DM5LR2B MI TT8FYO9 DM5LR2B MN Platelet-derived growth factor receptor alpha (PDGFRA) DM5LR2B MT DTT DM5LR2B MA Inhibitor DM5LR2B RN Biochemical and cellular effects of c-Src kinase-selective pyrido[2, 3-d]pyrimidine tyrosine kinase inhibitors. Biochem Pharmacol. 2000 Oct 1;60(7):885-98. DM5LR2B RU https://pubmed.ncbi.nlm.nih.gov/10974196 DM5LR2B DI DM5LR2B DM5LR2B DN HKI-9924129 DM5LR2B MI TTI7421 DM5LR2B MN Platelet-derived growth factor receptor beta (PDGFRB) DM5LR2B MT DTT DM5LR2B MA Inhibitor DM5LR2B RN Biochemical and cellular effects of c-Src kinase-selective pyrido[2, 3-d]pyrimidine tyrosine kinase inhibitors. Biochem Pharmacol. 2000 Oct 1;60(7):885-98. DM5LR2B RU https://pubmed.ncbi.nlm.nih.gov/10974196 DM5LR2B DI DM5LR2B DM5LR2B DN HKI-9924129 DM5LR2B MI TT6PKBN DM5LR2B MN Proto-oncogene c-Src (SRC) DM5LR2B MT DTT DM5LR2B MA Inhibitor DM5LR2B RN Biochemical and cellular effects of c-Src kinase-selective pyrido[2, 3-d]pyrimidine tyrosine kinase inhibitors. Biochem Pharmacol. 2000 Oct 1;60(7):885-98. DM5LR2B RU https://pubmed.ncbi.nlm.nih.gov/10974196 DMDINX9 DI DMDINX9 DMDINX9 DN H-KPPR-OH DMDINX9 MI TTIPJCB DMDINX9 MN Neuropilin-1 (NRP1) DMDINX9 MT DTT DMDINX9 MA Inhibitor DMDINX9 RN Small molecule inhibitors of the neuropilin-1 vascular endothelial growth factor A (VEGF-A) interaction. J Med Chem. 2010 Mar 11;53(5):2215-26. DMDINX9 RU https://pubmed.ncbi.nlm.nih.gov/20151671 DMMW0OF DI DMMW0OF DMMW0OF DN HL-034 DMMW0OF MI TTIHYA4 DMMW0OF MN Thrombopoietin receptor (MPL) DMMW0OF MT DTT DMMW0OF MA Antagonist DMMW0OF RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1722). DMMW0OF RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1722 DMAPWC2 DI DMAPWC2 DMAPWC2 DN H-Leu-Phe-NH2 DMAPWC2 MI TTZPO1L DMAPWC2 MN Substance-P receptor (TACR1) DMAPWC2 MT DTT DMAPWC2 MA Inhibitor DMAPWC2 RN Discovery of dipeptides with high affinity to the specific binding site for substance P1-7. J Med Chem. 2010 Mar 25;53(6):2383-9. DMAPWC2 RU https://pubmed.ncbi.nlm.nih.gov/20178322 DM2URWO DI DM2URWO DM2URWO DN HLL1-Fab-A3B3 DM2URWO MI TTY6DTE DM2URWO MN Carcinoembryonic antigen CEA (CD66e) DM2URWO MT DTT DM2URWO RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2836). DM2URWO RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2836 DMDXIS7 DI DMDXIS7 DMDXIS7 DN H-Lys-Arg-Pro-Hyp-Gly-Igl-Ser-D-BT-OH(JMV1645) DMDXIS7 MI TTG5QIA DMDXIS7 MN B1 bradykinin receptor (BDKRB1) DMDXIS7 MT DTT DMDXIS7 MA Inhibitor DMDXIS7 RN Synthesis and biological evaluation of bradykinin B(1)/B(2) and selective B(1) receptor antagonists. J Med Chem. 2000 Jun 15;43(12):2382-6. DMDXIS7 RU https://pubmed.ncbi.nlm.nih.gov/10882364 DMDXIS7 DI DMDXIS7 DMDXIS7 DN H-Lys-Arg-Pro-Hyp-Gly-Igl-Ser-D-BT-OH(JMV1645) DMDXIS7 MI TTGY8IW DMDXIS7 MN B2 bradykinin receptor (BDKRB2) DMDXIS7 MT DTT DMDXIS7 MA Inhibitor DMDXIS7 RN Synthesis and biological evaluation of bradykinin B(1)/B(2) and selective B(1) receptor antagonists. J Med Chem. 2000 Jun 15;43(12):2382-6. DMDXIS7 RU https://pubmed.ncbi.nlm.nih.gov/10882364 DMTGU0L DI DMTGU0L DMTGU0L DN H-Lys-Arg-Pro-Hyp-Gly-Thi-Ser-D-BT-OH(JMV1669) DMTGU0L MI TTG5QIA DMTGU0L MN B1 bradykinin receptor (BDKRB1) DMTGU0L MT DTT DMTGU0L MA Inhibitor DMTGU0L RN Synthesis and biological evaluation of bradykinin B(1)/B(2) and selective B(1) receptor antagonists. J Med Chem. 2000 Jun 15;43(12):2382-6. DMTGU0L RU https://pubmed.ncbi.nlm.nih.gov/10882364 DMTGU0L DI DMTGU0L DMTGU0L DN H-Lys-Arg-Pro-Hyp-Gly-Thi-Ser-D-BT-OH(JMV1669) DMTGU0L MI TTGY8IW DMTGU0L MN B2 bradykinin receptor (BDKRB2) DMTGU0L MT DTT DMTGU0L MA Inhibitor DMTGU0L RN Synthesis and biological evaluation of bradykinin B(1)/B(2) and selective B(1) receptor antagonists. J Med Chem. 2000 Jun 15;43(12):2382-6. DMTGU0L RU https://pubmed.ncbi.nlm.nih.gov/10882364 DMKHVUE DI DMKHVUE DMKHVUE DN HM-5016699 DMKHVUE MI TTHBTOP DMKHVUE MN PI3-kinase gamma (PIK3CG) DMKHVUE MT DTT DMKHVUE MA Inhibitor DMKHVUE RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2155). DMKHVUE RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2155 DMKHVUE DI DMKHVUE DMKHVUE DN HM-5016699 DMKHVUE MI TTCJG29 DMKHVUE MN Serine/threonine-protein kinase mTOR (mTOR) DMKHVUE MT DTT DMKHVUE MA Inhibitor DMKHVUE RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2109). DMKHVUE RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2109 DMNOFTX DI DMNOFTX DMNOFTX DN HM-61713B DMNOFTX MI TTGKNB4 DMNOFTX MN Epidermal growth factor receptor (EGFR) DMNOFTX MT DTT DMNOFTX MA Inhibitor DMNOFTX RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1797). DMNOFTX RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1797 DM17QMV DI DM17QMV DM17QMV DN H-mCpa-ala-Gly-Phe-leu-OH DM17QMV MI TT27RFC DM17QMV MN Opioid receptor delta (OPRD1) DM17QMV MT DTT DM17QMV MA Inhibitor DM17QMV RN Further studies of tyrosine surrogates in opioid receptor peptide ligands. Bioorg Med Chem Lett. 2007 May 1;17(9):2656-60. DM17QMV RU https://pubmed.ncbi.nlm.nih.gov/17350835 DM17QMV DI DM17QMV DM17QMV DN H-mCpa-ala-Gly-Phe-leu-OH DM17QMV MI TTKWM86 DM17QMV MN Opioid receptor mu (MOP) DM17QMV MT DTT DM17QMV MA Inhibitor DM17QMV RN Further studies of tyrosine surrogates in opioid receptor peptide ligands. Bioorg Med Chem Lett. 2007 May 1;17(9):2656-60. DM17QMV RU https://pubmed.ncbi.nlm.nih.gov/17350835 DMKAEQP DI DMKAEQP DMKAEQP DN H-mCpa-Gly-Gly-Phe-Leu-OH DMKAEQP MI TT27RFC DMKAEQP MN Opioid receptor delta (OPRD1) DMKAEQP MT DTT DMKAEQP MA Inhibitor DMKAEQP RN Further studies of tyrosine surrogates in opioid receptor peptide ligands. Bioorg Med Chem Lett. 2007 May 1;17(9):2656-60. DMKAEQP RU https://pubmed.ncbi.nlm.nih.gov/17350835 DM8OUHV DI DM8OUHV DM8OUHV DN H-mCpa-ser-Gly-Phe-Leu-Thr-OH DM8OUHV MI TT27RFC DM8OUHV MN Opioid receptor delta (OPRD1) DM8OUHV MT DTT DM8OUHV MA Inhibitor DM8OUHV RN Further studies of tyrosine surrogates in opioid receptor peptide ligands. Bioorg Med Chem Lett. 2007 May 1;17(9):2656-60. DM8OUHV RU https://pubmed.ncbi.nlm.nih.gov/17350835 DM8OUHV DI DM8OUHV DM8OUHV DN H-mCpa-ser-Gly-Phe-Leu-Thr-OH DM8OUHV MI TTKWM86 DM8OUHV MN Opioid receptor mu (MOP) DM8OUHV MT DTT DM8OUHV MA Inhibitor DM8OUHV RN Further studies of tyrosine surrogates in opioid receptor peptide ligands. Bioorg Med Chem Lett. 2007 May 1;17(9):2656-60. DM8OUHV RU https://pubmed.ncbi.nlm.nih.gov/17350835 DMXMTA9 DI DMXMTA9 DMXMTA9 DN HMR-1556 DMXMTA9 MI TT846HF DMXMTA9 MN Voltage-gated potassium channel Kv7.1 (KCNQ1) DMXMTA9 MT DTT DMXMTA9 MA Inhibitor DMXMTA9 RN Selective optimization of side activities: another way for drug discovery. J Med Chem. 2004 Mar 11;47(6):1303-14. DMXMTA9 RU https://pubmed.ncbi.nlm.nih.gov/14998318 DMNXR17 DI DMNXR17 DMNXR17 DN HMR1883 DMNXR17 MI TT1VOHK DMNXR17 MN Potassium channel unspecific (KC) DMNXR17 MT DTT DMNXR17 MA Modulator DMNXR17 RN Clamikalant (Aventis). IDrugs. 2000 Nov;3(11):1353-7. DMNXR17 RU https://www.ncbi.nlm.nih.gov/pubmed/16047257 DMUPS48 DI DMUPS48 DMUPS48 DN HMS3229G13 DMUPS48 MI TTK0FEA DMUPS48 MN Leucine-rich repeat kinase 2 (LRRK2) DMUPS48 MT DTT DMUPS48 MA Inhibitor DMUPS48 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2059). DMUPS48 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2059 DMKOMP2 DI DMKOMP2 DMKOMP2 DN HOE-33258 DMKOMP2 MI TTQY2EJ DMKOMP2 MN TERT messenger RNA (TERT mRNA) DMKOMP2 MT DTT DMKOMP2 MA Inhibitor DMKOMP2 RN Nucleic acid-binding ligands identify new mechanisms to inhibit telomerase. Bioorg Med Chem Lett. 2004 Jul 5;14(13):3467-71. DMKOMP2 RU https://pubmed.ncbi.nlm.nih.gov/15177454 DMJQI7A DI DMJQI7A DMJQI7A DN HO-LVA DMJQI7A MI TT4TFGN DMJQI7A MN Vasopressin V1a receptor (V1AR) DMJQI7A MT DTT DMJQI7A MA Inhibitor DMJQI7A RN Toward efficient drug screening by homogeneous assays based on the development of new fluorescent vasopressin and oxytocin receptor ligands. J Med Chem. 2007 Oct 4;50(20):4976-85. DMJQI7A RU https://pubmed.ncbi.nlm.nih.gov/17850055 DMZYB3S DI DMZYB3S DMZYB3S DN Hombreol DMZYB3S MI DE36TMY DMZYB3S MN Cytochrome P450 7B1 (CYP7B1) DMZYB3S MT DME DMZYB3S MA Metabolism DMZYB3S RN CYP7B1-mediated metabolism of dehydroepiandrosterone and 5alpha-androstane-3beta,17beta-diol--potential role(s) for estrogen signaling. FEBS J. 2008 Apr;275(8):1778-89. DMZYB3S RU https://pubmed.ncbi.nlm.nih.gov/18331353 DMZYB3S DI DMZYB3S DMZYB3S DN Hombreol DMZYB3S MI DEPFD73 DMZYB3S MN Dehydrogenase/reductase retSDR2 (HSD17B11) DMZYB3S MT DME DMZYB3S MA Metabolism DMZYB3S RN Transcriptional regulation of type 11 17beta-hydroxysteroid dehydrogenase expression in prostate cancer cells. Mol Cell Endocrinol. 2011 Jun 6;339(1-2):45-53. DMZYB3S RU https://pubmed.ncbi.nlm.nih.gov/21549806 DMH96AI DI DMH96AI DMH96AI DN homo-AMPA DMH96AI MI TTWRP2F DMH96AI MN Metabotropic glutamate receptor 6 (mGluR6) DMH96AI MT DTT DMH96AI MA Agonist DMH96AI RN A new highly selective metabotropic excitatory amino acid agonist: 2-amino-4-(3-hydroxy-5-methylisoxazol-4-yl)butyric acid. J Med Chem. 1996 Aug 2;39(16):3188-94. DMH96AI RU https://pubmed.ncbi.nlm.nih.gov/8759641 DMIHFQY DI DMIHFQY DMIHFQY DN HOMOAROMOLINE DMIHFQY MI TTVBI8W DMIHFQY MN Dopamine transporter (DAT) DMIHFQY MT DTT DMIHFQY MA Inhibitor DMIHFQY RN Effects of various isoquinoline alkaloids on in vitro 3H-dopamine uptake by rat striatal synaptosomes. J Nat Prod. 1995 Oct;58(10):1475-84. DMIHFQY RU https://pubmed.ncbi.nlm.nih.gov/8676127 DMCIRY0 DI DMCIRY0 DMCIRY0 DN Homocamptothecins (hCPTs) DMCIRY0 MI TTGTQHC DMCIRY0 MN DNA topoisomerase I (TOP1) DMCIRY0 MT DTT DMCIRY0 MA Inhibitor DMCIRY0 RN Homocamptothecins: potent topoisomerase I inhibitors and promising anticancer drugs. Crit Rev Oncol Hematol. 2003 Jan;45(1):91-108. DMCIRY0 RU https://pubmed.ncbi.nlm.nih.gov/12482574 DM1SDN8 DI DM1SDN8 DM1SDN8 DN HOMOERIODICTYOL DM1SDN8 MI TTI84H7 DM1SDN8 MN Cytochrome P450 1B1 (CYP1B1) DM1SDN8 MT DTT DM1SDN8 MA Inhibitor DM1SDN8 RN Selective inhibition of methoxyflavonoids on human CYP1B1 activity. Bioorg Med Chem. 2010 Sep 1;18(17):6310-5. DM1SDN8 RU https://pubmed.ncbi.nlm.nih.gov/20696580 DMQD0YW DI DMQD0YW DMQD0YW DN Homogentisic acid DMQD0YW MI DESDN74 DMQD0YW MN Serum paraoxonase/arylesterase 1 (PON1) DMQD0YW MT DME DMQD0YW MA Metabolism DMQD0YW RN Human serum paraoxonase (PON1) isozymes Q and R hydrolyze lactones and cyclic carbonate esters. Drug Metab Dispos. 2000 Nov;28(11):1335-42. DMQD0YW RU https://www.ncbi.nlm.nih.gov/pubmed/?term=11038162 DMVBTHA DI DMVBTHA DMVBTHA DN HOMOPHENYLALANINYLMETHANE DMVBTHA MI TTJOKD1 DMVBTHA MN Cathepsin F (CTSF) DMVBTHA MT DTT DMVBTHA MA Inhibitor DMVBTHA RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DMVBTHA RU https://pubmed.ncbi.nlm.nih.gov/10592235 DMBW5DU DI DMBW5DU DMBW5DU DN homoquinolinic acid DMBW5DU MI TTLD29N DMBW5DU MN Glutamate receptor ionotropic NMDA 1 (NMDAR1) DMBW5DU MT DTT DMBW5DU MA Agonist DMBW5DU RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 455). DMBW5DU RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=455 DMBW5DU DI DMBW5DU DMBW5DU DN homoquinolinic acid DMBW5DU MI TTKJEMQ DMBW5DU MN Glutamate receptor ionotropic NMDA 2A (NMDAR2A) DMBW5DU MT DTT DMBW5DU MA Agonist DMBW5DU RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 456). DMBW5DU RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=456 DMBW5DU DI DMBW5DU DMBW5DU DN homoquinolinic acid DMBW5DU MI TTN9D8E DMBW5DU MN Glutamate receptor ionotropic NMDA 2B (NMDAR2B) DMBW5DU MT DTT DMBW5DU MA Agonist DMBW5DU RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 457). DMBW5DU RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=457 DMBW5DU DI DMBW5DU DMBW5DU DN homoquinolinic acid DMBW5DU MI TT1M8OW DMBW5DU MN Glutamate receptor ionotropic NMDA 2C (GluN2C) DMBW5DU MT DTT DMBW5DU MA Agonist DMBW5DU RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 458). DMBW5DU RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=458 DMBW5DU DI DMBW5DU DMBW5DU DN homoquinolinic acid DMBW5DU MI TT5POTG DMBW5DU MN Glutamate receptor ionotropic NMDA 2D (GluN2D) DMBW5DU MT DTT DMBW5DU MA Agonist DMBW5DU RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 459). DMBW5DU RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=459 DMX8DC2 DI DMX8DC2 DMX8DC2 DN Homorisedronate DMX8DC2 MI TTIKWV4 DMX8DC2 MN Geranyltranstransferase (FDPS) DMX8DC2 MT DTT DMX8DC2 MA Inhibitor DMX8DC2 RN Bisphosphonates are potent inhibitors of Trypanosoma cruzi farnesyl pyrophosphate synthase. J Biol Chem. 2001 Sep 7;276(36):33930-7. DMX8DC2 RU https://pubmed.ncbi.nlm.nih.gov/11435429 DMTKN4A DI DMTKN4A DMTKN4A DN Homoserine Lactone DMTKN4A MI TTGSEFH DMTKN4A MN Sodium/hydrogen exchanger 1 (SLC9A1) DMTKN4A MT DTT DMTKN4A MA Inhibitor DMTKN4A RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMTKN4A RU https://pubmed.ncbi.nlm.nih.gov/17139284 DM0SHPY DI DM0SHPY DM0SHPY DN Homovanillic acid DM0SHPY MI DEJOCPK DM0SHPY MN Homogentisate 1,2-dioxygenase (hmgA) DM0SHPY MT DME DM0SHPY MA Metabolism DM0SHPY RN nan DM0SHPY RU nan DMI7258 DI DMI7258 DMI7258 DN Homspera DMI7258 MI TTZPO1L DMI7258 MN Substance-P receptor (TACR1) DMI7258 MT DTT DMI7258 MA Agonist DMI7258 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 360). DMI7258 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=360 DMJWT3X DI DMJWT3X DMJWT3X DN HONOKIOL DMJWT3X MI TTSJ6Q4 DMJWT3X MN LOX-5 messenger RNA (ALOX5 mRNA) DMJWT3X MT DTT DMJWT3X MA Inhibitor DMJWT3X RN Design and synthesis of ten biphenyl-neolignan derivatives and their in vitro inhibitory potency against cyclooxygenase-1/2 activity and 5-lipoxyge... Bioorg Med Chem. 2009 Jul 1;17(13):4459-65. DMJWT3X RU https://pubmed.ncbi.nlm.nih.gov/19481465 DMJWT3X DI DMJWT3X DMJWT3X DN HONOKIOL DMJWT3X MI TT8NGED DMJWT3X MN Prostaglandin G/H synthase 1 (COX-1) DMJWT3X MT DTT DMJWT3X MA Inhibitor DMJWT3X RN Design and synthesis of ten biphenyl-neolignan derivatives and their in vitro inhibitory potency against cyclooxygenase-1/2 activity and 5-lipoxyge... Bioorg Med Chem. 2009 Jul 1;17(13):4459-65. DMJWT3X RU https://pubmed.ncbi.nlm.nih.gov/19481465 DMJWT3X DI DMJWT3X DMJWT3X DN HONOKIOL DMJWT3X MI TTVKILB DMJWT3X MN Prostaglandin G/H synthase 2 (COX-2) DMJWT3X MT DTT DMJWT3X MA Inhibitor DMJWT3X RN Design and synthesis of ten biphenyl-neolignan derivatives and their in vitro inhibitory potency against cyclooxygenase-1/2 activity and 5-lipoxyge... Bioorg Med Chem. 2009 Jul 1;17(13):4459-65. DMJWT3X RU https://pubmed.ncbi.nlm.nih.gov/19481465 DMHW2DU DI DMHW2DU DMHW2DU DN Hoo-Phe-Orn-Pro-hle-Pff-Phe-NH2 DMHW2DU MI TTD0CIQ DMHW2DU MN Melanocortin receptor 4 (MC4R) DMHW2DU MT DTT DMHW2DU MA Inhibitor DMHW2DU RN Peptidomimetic C5a receptor antagonists with hydrophobic substitutions at the C-terminus: increased receptor specificity and in vivo activity. Bioorg Med Chem Lett. 2006 Oct 1;16(19):5088-92. DMHW2DU RU https://pubmed.ncbi.nlm.nih.gov/16876401 DMHW2DU DI DMHW2DU DMHW2DU DN Hoo-Phe-Orn-Pro-hle-Pff-Phe-NH2 DMHW2DU MI TTYO0A3 DMHW2DU MN Substance-K receptor (TACR2) DMHW2DU MT DTT DMHW2DU MA Inhibitor DMHW2DU RN Peptidomimetic C5a receptor antagonists with hydrophobic substitutions at the C-terminus: increased receptor specificity and in vivo activity. Bioorg Med Chem Lett. 2006 Oct 1;16(19):5088-92. DMHW2DU RU https://pubmed.ncbi.nlm.nih.gov/16876401 DMHW2DU DI DMHW2DU DMHW2DU DN Hoo-Phe-Orn-Pro-hle-Pff-Phe-NH2 DMHW2DU MI TT4TFGN DMHW2DU MN Vasopressin V1a receptor (V1AR) DMHW2DU MT DTT DMHW2DU MA Inhibitor DMHW2DU RN Peptidomimetic C5a receptor antagonists with hydrophobic substitutions at the C-terminus: increased receptor specificity and in vivo activity. Bioorg Med Chem Lett. 2006 Oct 1;16(19):5088-92. DMHW2DU RU https://pubmed.ncbi.nlm.nih.gov/16876401 DM2OZBL DI DM2OZBL DM2OZBL DN Howiinol A (GHM-10) DM2OZBL MI TT0IHXV DM2OZBL MN DNA topoisomerase II (TOP2) DM2OZBL MT DTT DM2OZBL MA Inhibitor DM2OZBL RN Anticancer effect of Howiinol A and its mechanism of action. J Asian Nat Prod Res. 1999;2(1):1-19. DM2OZBL RU https://pubmed.ncbi.nlm.nih.gov/11261201 DM9IODG DI DM9IODG DM9IODG DN H-Phe-NH2 DM9IODG MI TTZPO1L DM9IODG MN Substance-P receptor (TACR1) DM9IODG MT DTT DM9IODG MA Inhibitor DM9IODG RN Discovery of dipeptides with high affinity to the specific binding site for substance P1-7. J Med Chem. 2010 Mar 25;53(6):2383-9. DM9IODG RU https://pubmed.ncbi.nlm.nih.gov/20178322 DM0KFW2 DI DM0KFW2 DM0KFW2 DN H-Phe-Phe-NH2 DM0KFW2 MI TTZPO1L DM0KFW2 MN Substance-P receptor (TACR1) DM0KFW2 MT DTT DM0KFW2 MA Inhibitor DM0KFW2 RN Discovery of dipeptides with high affinity to the specific binding site for substance P1-7. J Med Chem. 2010 Mar 25;53(6):2383-9. DM0KFW2 RU https://pubmed.ncbi.nlm.nih.gov/20178322 DME1CT9 DI DME1CT9 DME1CT9 DN H-Poa-ser-Gly-Phe-Leu-Thr-OH DME1CT9 MI TT27RFC DME1CT9 MN Opioid receptor delta (OPRD1) DME1CT9 MT DTT DME1CT9 MA Inhibitor DME1CT9 RN Further studies of tyrosine surrogates in opioid receptor peptide ligands. Bioorg Med Chem Lett. 2007 May 1;17(9):2656-60. DME1CT9 RU https://pubmed.ncbi.nlm.nih.gov/17350835 DMXKPQR DI DMXKPQR DMXKPQR DN H-Pro-Phe-Phe-NH2 DMXKPQR MI TTZPO1L DMXKPQR MN Substance-P receptor (TACR1) DMXKPQR MT DTT DMXKPQR MA Inhibitor DMXKPQR RN Discovery of dipeptides with high affinity to the specific binding site for substance P1-7. J Med Chem. 2010 Mar 25;53(6):2383-9. DMXKPQR RU https://pubmed.ncbi.nlm.nih.gov/20178322 DMRPZD4 DI DMRPZD4 DMRPZD4 DN HPTE DMRPZD4 MI TTOM3J0 DMRPZD4 MN Estrogen receptor beta (ESR2) DMRPZD4 MT DTT DMRPZD4 MA Antagonist DMRPZD4 RN Signalling by CXC-chemokine receptors 1 and 2 expressed in CHO cells: a comparison of calcium mobilization, inhibition of adenylyl cyclase and stimulation of GTPgammaS binding induced by IL-8 and GROalpha. Br J Pharmacol. 1999 Feb;126(3):810-8. DMRPZD4 RU https://pubmed.ncbi.nlm.nih.gov/10188995 DMSHYQ3 DI DMSHYQ3 DMSHYQ3 DN HQL-79 DMSHYQ3 MI TTCYE56 DMSHYQ3 MN Glutathione-dependent PGD synthase (HPGDS) DMSHYQ3 MT DTT DMSHYQ3 MA Inhibitor DMSHYQ3 RN Structural and functional characterization of HQL-79, an orally selective inhibitor of human hematopoietic prostaglandin D synthase. J Biol Chem. 2006 Jun 2;281(22):15277-86. DMSHYQ3 RU https://pubmed.ncbi.nlm.nih.gov/16547010 DMSTV96 DI DMSTV96 DMSTV96 DN H-RYYRIK-NH2 DMSTV96 MI TTNT7K8 DMSTV96 MN Nociceptin receptor (OPRL1) DMSTV96 MT DTT DMSTV96 MA Inhibitor DMSTV96 RN Designed modification of partial agonist of ORL1 nociceptin receptor for conversion into highly potent antagonist. Bioorg Med Chem. 2008 Mar 1;16(5):2635-44. DMSTV96 RU https://pubmed.ncbi.nlm.nih.gov/18068993 DMM3FD2 DI DMM3FD2 DMM3FD2 DN HS014 DMM3FD2 MI TTD0CIQ DMM3FD2 MN Melanocortin receptor 4 (MC4R) DMM3FD2 MT DTT DMM3FD2 MA Antagonist DMM3FD2 RN Long-term administration of MC4 receptor antagonist HS014 causes hyperphagia and obesity in rats. Neuroreport. 1999 Mar 17;10(4):707-11. DMM3FD2 RU https://pubmed.ncbi.nlm.nih.gov/10208535 DM0A2UF DI DM0A2UF DM0A2UF DN HS-173 DM0A2UF MI TTHBTOP DM0A2UF MN PI3-kinase gamma (PIK3CG) DM0A2UF MT DTT DM0A2UF MA Inhibitor DM0A2UF RN Design and synthesis of imidazopyridine analogues as inhibitors of phosphoinositide 3-kinase signaling and angiogenesis. J Med Chem. 2011 Apr 14;54(7):2455-66. DM0A2UF RU https://pubmed.ncbi.nlm.nih.gov/21388141 DMA91T4 DI DMA91T4 DMA91T4 DN H-SMGLPCVVM-OH DMA91T4 MI TT7WZIJ DMA91T4 MN CAAX farnesyltransferase beta (FNTB) DMA91T4 MT DTT DMA91T4 MA Inhibitor DMA91T4 RN Improvement of biological activity and proteolytic stability of peptides by coupling with a cyclic peptide. Bioorg Med Chem Lett. 2003 Aug 4;13(15):2583-6. DMA91T4 RU https://pubmed.ncbi.nlm.nih.gov/12852971 DMZRPM5 DI DMZRPM5 DMZRPM5 DN HT1042 DMZRPM5 MI TTEAD9J DMZRPM5 MN Proteasome beta-8 (PS beta-8) DMZRPM5 MT DTT DMZRPM5 MA Inhibitor DMZRPM5 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2408). DMZRPM5 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2408 DMRF73O DI DMRF73O DMRF73O DN HT-2678 DMRF73O MI TTNZPQ1 DMRF73O MN GABA(A) receptor alpha-5 (GABRA5) DMRF73O MT DTT DMRF73O MA Agonist DMRF73O RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 408). DMRF73O RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=408 DMPT8JN DI DMPT8JN DMPT8JN DN HTMT DMPT8JN MI TTXJ178 DMPT8JN MN Histamine H4 receptor (H4R) DMPT8JN MT DTT DMPT8JN MA Agonist DMPT8JN RN Cloning, expression, and pharmacological characterization of a novel human histamine receptor. Mol Pharmacol. 2001 Mar;59(3):434-41. DMPT8JN RU https://pubmed.ncbi.nlm.nih.gov/11179436 DMQ8ADE DI DMQ8ADE DMQ8ADE DN HTS-00213 DMQ8ADE MI TTGKNB4 DMQ8ADE MN Epidermal growth factor receptor (EGFR) DMQ8ADE MT DTT DMQ8ADE MA Inhibitor DMQ8ADE RN Computational studies of epidermal growth factor receptor: docking reliability, three-dimensional quantitative structure-activity relationship anal... J Med Chem. 2009 Feb 26;52(4):964-75. DMQ8ADE RU https://pubmed.ncbi.nlm.nih.gov/19170633 DMXV379 DI DMXV379 DMXV379 DN HTS-00798 DMXV379 MI TTDP1UC DMXV379 MN Fatty acid amide hydrolase (FAAH) DMXV379 MT DTT DMXV379 MA Inhibitor DMXV379 RN Fatty acid amide hydrolase inhibitors from virtual screening of the endocannabinoid system. J Med Chem. 2006 Jul 27;49(15):4650-6. DMXV379 RU https://pubmed.ncbi.nlm.nih.gov/16854070 DMVUTJ5 DI DMVUTJ5 DMVUTJ5 DN HTS-02876 DMVUTJ5 MI TTGKNB4 DMVUTJ5 MN Epidermal growth factor receptor (EGFR) DMVUTJ5 MT DTT DMVUTJ5 MA Inhibitor DMVUTJ5 RN Computational studies of epidermal growth factor receptor: docking reliability, three-dimensional quantitative structure-activity relationship anal... J Med Chem. 2009 Feb 26;52(4):964-75. DMVUTJ5 RU https://pubmed.ncbi.nlm.nih.gov/19170633 DM3F4IQ DI DM3F4IQ DM3F4IQ DN HTS-05058 DM3F4IQ MI TTGKNB4 DM3F4IQ MN Epidermal growth factor receptor (EGFR) DM3F4IQ MT DTT DM3F4IQ MA Inhibitor DM3F4IQ RN A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases. Proc Natl Acad Sci U S A. 2007 Dec 18;104(51):20523-8. DM3F4IQ RU https://pubmed.ncbi.nlm.nih.gov/18077363 DM70YTF DI DM70YTF DM70YTF DN HTS-466284 DM70YTF MI TTP4520 DM70YTF MN TGF-beta receptor type I (TGFBR1) DM70YTF MT DTT DM70YTF MA Inhibitor DM70YTF RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DM70YTF RU https://pubmed.ncbi.nlm.nih.gov/10592235 DMX08FL DI DMX08FL DMX08FL DN H-Tyr(OMe)-Phe(2-Me)-NH2 DMX08FL MI TTZPO1L DMX08FL MN Substance-P receptor (TACR1) DMX08FL MT DTT DMX08FL MA Inhibitor DMX08FL RN Discovery of dipeptides with high affinity to the specific binding site for substance P1-7. J Med Chem. 2010 Mar 25;53(6):2383-9. DMX08FL RU https://pubmed.ncbi.nlm.nih.gov/20178322 DMUHBGC DI DMUHBGC DMUHBGC DN H-Tyr-Ala-Phe-Phe-NH2 DMUHBGC MI TTZPO1L DMUHBGC MN Substance-P receptor (TACR1) DMUHBGC MT DTT DMUHBGC MA Inhibitor DMUHBGC RN Discovery of dipeptides with high affinity to the specific binding site for substance P1-7. J Med Chem. 2010 Mar 25;53(6):2383-9. DMUHBGC RU https://pubmed.ncbi.nlm.nih.gov/20178322 DMP8KMV DI DMP8KMV DMP8KMV DN H-Tyr-c[cys-Gly-Phe(p-NO2)-cys]NH2 DMP8KMV MI TT27RFC DMP8KMV MN Opioid receptor delta (OPRD1) DMP8KMV MT DTT DMP8KMV MA Inhibitor DMP8KMV RN Further studies of tyrosine surrogates in opioid receptor peptide ligands. Bioorg Med Chem Lett. 2007 May 1;17(9):2656-60. DMP8KMV RU https://pubmed.ncbi.nlm.nih.gov/17350835 DM48XV0 DI DM48XV0 DM48XV0 DN H-Tyr-c[D-Allylgly-Gly-Phe-D-Allylgly]NH2 DM48XV0 MI TT27RFC DM48XV0 MN Opioid receptor delta (OPRD1) DM48XV0 MT DTT DM48XV0 MA Inhibitor DM48XV0 RN Dicarba analogues of the cyclic enkephalin peptides H-Tyr-c[D-Cys-Gly-Phe-D(or L)-Cys]NH(2) retain high opioid activity. J Med Chem. 2007 Mar 22;50(6):1414-7. DM48XV0 RU https://pubmed.ncbi.nlm.nih.gov/17315860 DM48XV0 DI DM48XV0 DM48XV0 DN H-Tyr-c[D-Allylgly-Gly-Phe-D-Allylgly]NH2 DM48XV0 MI TTQW87Y DM48XV0 MN Opioid receptor kappa (OPRK1) DM48XV0 MT DTT DM48XV0 MA Inhibitor DM48XV0 RN Dicarba analogues of the cyclic enkephalin peptides H-Tyr-c[D-Cys-Gly-Phe-D(or L)-Cys]NH(2) retain high opioid activity. J Med Chem. 2007 Mar 22;50(6):1414-7. DM48XV0 RU https://pubmed.ncbi.nlm.nih.gov/17315860 DM48XV0 DI DM48XV0 DM48XV0 DN H-Tyr-c[D-Allylgly-Gly-Phe-D-Allylgly]NH2 DM48XV0 MI TTKWM86 DM48XV0 MN Opioid receptor mu (MOP) DM48XV0 MT DTT DM48XV0 MA Inhibitor DM48XV0 RN Dicarba analogues of the cyclic enkephalin peptides H-Tyr-c[D-Cys-Gly-Phe-D(or L)-Cys]NH(2) retain high opioid activity. J Med Chem. 2007 Mar 22;50(6):1414-7. DM48XV0 RU https://pubmed.ncbi.nlm.nih.gov/17315860 DMA2CZL DI DMA2CZL DMA2CZL DN H-Tyr-c[D-Allylgly-Gly-Phe-D-Allylgly]-OH DMA2CZL MI TT27RFC DMA2CZL MN Opioid receptor delta (OPRD1) DMA2CZL MT DTT DMA2CZL MA Inhibitor DMA2CZL RN Synthesis of stable and potent delta/mu opioid peptides: analogues of H-Tyr-c[D-Cys-Gly-Phe-D-Cys]-OH by ring-closing metathesis. J Med Chem. 2007 Jun 28;50(13):3138-42. DMA2CZL RU https://pubmed.ncbi.nlm.nih.gov/17539621 DMA2CZL DI DMA2CZL DMA2CZL DN H-Tyr-c[D-Allylgly-Gly-Phe-D-Allylgly]-OH DMA2CZL MI TTQW87Y DMA2CZL MN Opioid receptor kappa (OPRK1) DMA2CZL MT DTT DMA2CZL MA Inhibitor DMA2CZL RN Synthesis of stable and potent delta/mu opioid peptides: analogues of H-Tyr-c[D-Cys-Gly-Phe-D-Cys]-OH by ring-closing metathesis. J Med Chem. 2007 Jun 28;50(13):3138-42. DMA2CZL RU https://pubmed.ncbi.nlm.nih.gov/17539621 DMA2CZL DI DMA2CZL DMA2CZL DN H-Tyr-c[D-Allylgly-Gly-Phe-D-Allylgly]-OH DMA2CZL MI TTKWM86 DMA2CZL MN Opioid receptor mu (MOP) DMA2CZL MT DTT DMA2CZL MA Inhibitor DMA2CZL RN Synthesis of stable and potent delta/mu opioid peptides: analogues of H-Tyr-c[D-Cys-Gly-Phe-D-Cys]-OH by ring-closing metathesis. J Med Chem. 2007 Jun 28;50(13):3138-42. DMA2CZL RU https://pubmed.ncbi.nlm.nih.gov/17539621 DMXPJHB DI DMXPJHB DMXPJHB DN H-Tyr-c[D-Allylgly-Gly-Phe-L-Allylgly]NH2 DMXPJHB MI TT27RFC DMXPJHB MN Opioid receptor delta (OPRD1) DMXPJHB MT DTT DMXPJHB MA Inhibitor DMXPJHB RN Dicarba analogues of the cyclic enkephalin peptides H-Tyr-c[D-Cys-Gly-Phe-D(or L)-Cys]NH(2) retain high opioid activity. J Med Chem. 2007 Mar 22;50(6):1414-7. DMXPJHB RU https://pubmed.ncbi.nlm.nih.gov/17315860 DMXPJHB DI DMXPJHB DMXPJHB DN H-Tyr-c[D-Allylgly-Gly-Phe-L-Allylgly]NH2 DMXPJHB MI TTQW87Y DMXPJHB MN Opioid receptor kappa (OPRK1) DMXPJHB MT DTT DMXPJHB MA Inhibitor DMXPJHB RN Dicarba analogues of the cyclic enkephalin peptides H-Tyr-c[D-Cys-Gly-Phe-D(or L)-Cys]NH(2) retain high opioid activity. J Med Chem. 2007 Mar 22;50(6):1414-7. DMXPJHB RU https://pubmed.ncbi.nlm.nih.gov/17315860 DMXPJHB DI DMXPJHB DMXPJHB DN H-Tyr-c[D-Allylgly-Gly-Phe-L-Allylgly]NH2 DMXPJHB MI TTKWM86 DMXPJHB MN Opioid receptor mu (MOP) DMXPJHB MT DTT DMXPJHB MA Inhibitor DMXPJHB RN Dicarba analogues of the cyclic enkephalin peptides H-Tyr-c[D-Cys-Gly-Phe-D(or L)-Cys]NH(2) retain high opioid activity. J Med Chem. 2007 Mar 22;50(6):1414-7. DMXPJHB RU https://pubmed.ncbi.nlm.nih.gov/17315860 DM7QAES DI DM7QAES DM7QAES DN H-Tyr-c[D-Cys-Gly-Phe-D-Cys]NH2 DM7QAES MI TT27RFC DM7QAES MN Opioid receptor delta (OPRD1) DM7QAES MT DTT DM7QAES MA Inhibitor DM7QAES RN Dicarba analogues of the cyclic enkephalin peptides H-Tyr-c[D-Cys-Gly-Phe-D(or L)-Cys]NH(2) retain high opioid activity. J Med Chem. 2007 Mar 22;50(6):1414-7. DM7QAES RU https://pubmed.ncbi.nlm.nih.gov/17315860 DM7QAES DI DM7QAES DM7QAES DN H-Tyr-c[D-Cys-Gly-Phe-D-Cys]NH2 DM7QAES MI TTQW87Y DM7QAES MN Opioid receptor kappa (OPRK1) DM7QAES MT DTT DM7QAES MA Inhibitor DM7QAES RN Dicarba analogues of the cyclic enkephalin peptides H-Tyr-c[D-Cys-Gly-Phe-D(or L)-Cys]NH(2) retain high opioid activity. J Med Chem. 2007 Mar 22;50(6):1414-7. DM7QAES RU https://pubmed.ncbi.nlm.nih.gov/17315860 DM7QAES DI DM7QAES DM7QAES DN H-Tyr-c[D-Cys-Gly-Phe-D-Cys]NH2 DM7QAES MI TTKWM86 DM7QAES MN Opioid receptor mu (MOP) DM7QAES MT DTT DM7QAES MA Inhibitor DM7QAES RN Dicarba analogues of the cyclic enkephalin peptides H-Tyr-c[D-Cys-Gly-Phe-D(or L)-Cys]NH(2) retain high opioid activity. J Med Chem. 2007 Mar 22;50(6):1414-7. DM7QAES RU https://pubmed.ncbi.nlm.nih.gov/17315860 DMZSTL5 DI DMZSTL5 DMZSTL5 DN H-Tyr-c[D-Cys-Gly-Phe-L-Cys]NH2 DMZSTL5 MI TT27RFC DMZSTL5 MN Opioid receptor delta (OPRD1) DMZSTL5 MT DTT DMZSTL5 MA Inhibitor DMZSTL5 RN Dicarba analogues of the cyclic enkephalin peptides H-Tyr-c[D-Cys-Gly-Phe-D(or L)-Cys]NH(2) retain high opioid activity. J Med Chem. 2007 Mar 22;50(6):1414-7. DMZSTL5 RU https://pubmed.ncbi.nlm.nih.gov/17315860 DMZSTL5 DI DMZSTL5 DMZSTL5 DN H-Tyr-c[D-Cys-Gly-Phe-L-Cys]NH2 DMZSTL5 MI TTQW87Y DMZSTL5 MN Opioid receptor kappa (OPRK1) DMZSTL5 MT DTT DMZSTL5 MA Inhibitor DMZSTL5 RN Dicarba analogues of the cyclic enkephalin peptides H-Tyr-c[D-Cys-Gly-Phe-D(or L)-Cys]NH(2) retain high opioid activity. J Med Chem. 2007 Mar 22;50(6):1414-7. DMZSTL5 RU https://pubmed.ncbi.nlm.nih.gov/17315860 DMZSTL5 DI DMZSTL5 DMZSTL5 DN H-Tyr-c[D-Cys-Gly-Phe-L-Cys]NH2 DMZSTL5 MI TTKWM86 DMZSTL5 MN Opioid receptor mu (MOP) DMZSTL5 MT DTT DMZSTL5 MA Inhibitor DMZSTL5 RN Dicarba analogues of the cyclic enkephalin peptides H-Tyr-c[D-Cys-Gly-Phe-D(or L)-Cys]NH(2) retain high opioid activity. J Med Chem. 2007 Mar 22;50(6):1414-7. DMZSTL5 RU https://pubmed.ncbi.nlm.nih.gov/17315860 DMI7CR9 DI DMI7CR9 DMI7CR9 DN H-Tyr-c[D-Orn-(D or L)Atc-Glu]-NH2 DMI7CR9 MI TT27RFC DMI7CR9 MN Opioid receptor delta (OPRD1) DMI7CR9 MT DTT DMI7CR9 MA Inhibitor DMI7CR9 RN Conformational restriction of the phenylalanine residue in a cyclic opioid peptide analogue: effects on receptor selectivity and stereospecificity. J Med Chem. 1991 Oct;34(10):3125-32. DMI7CR9 RU https://pubmed.ncbi.nlm.nih.gov/1656045 DMI7CR9 DI DMI7CR9 DMI7CR9 DN H-Tyr-c[D-Orn-(D or L)Atc-Glu]-NH2 DMI7CR9 MI TTKWM86 DMI7CR9 MN Opioid receptor mu (MOP) DMI7CR9 MT DTT DMI7CR9 MA Inhibitor DMI7CR9 RN Conformational restriction of the phenylalanine residue in a cyclic opioid peptide analogue: effects on receptor selectivity and stereospecificity. J Med Chem. 1991 Oct;34(10):3125-32. DMI7CR9 RU https://pubmed.ncbi.nlm.nih.gov/1656045 DMOTI0P DI DMOTI0P DMOTI0P DN H-Tyr-c[D-Orn-Aic-Glu]-NH2 DMOTI0P MI TT27RFC DMOTI0P MN Opioid receptor delta (OPRD1) DMOTI0P MT DTT DMOTI0P MA Inhibitor DMOTI0P RN Conformational restriction of the phenylalanine residue in a cyclic opioid peptide analogue: effects on receptor selectivity and stereospecificity. J Med Chem. 1991 Oct;34(10):3125-32. DMOTI0P RU https://pubmed.ncbi.nlm.nih.gov/1656045 DMOTI0P DI DMOTI0P DMOTI0P DN H-Tyr-c[D-Orn-Aic-Glu]-NH2 DMOTI0P MI TTKWM86 DMOTI0P MN Opioid receptor mu (MOP) DMOTI0P MT DTT DMOTI0P MA Inhibitor DMOTI0P RN Conformational restriction of the phenylalanine residue in a cyclic opioid peptide analogue: effects on receptor selectivity and stereospecificity. J Med Chem. 1991 Oct;34(10):3125-32. DMOTI0P RU https://pubmed.ncbi.nlm.nih.gov/1656045 DMAKPM1 DI DMAKPM1 DMAKPM1 DN H-Tyr-c[pen-Gly-Phe-pen]OH DMAKPM1 MI TT27RFC DMAKPM1 MN Opioid receptor delta (OPRD1) DMAKPM1 MT DTT DMAKPM1 MA Inhibitor DMAKPM1 RN Further studies of tyrosine surrogates in opioid receptor peptide ligands. Bioorg Med Chem Lett. 2007 May 1;17(9):2656-60. DMAKPM1 RU https://pubmed.ncbi.nlm.nih.gov/17350835 DMN2AQO DI DMN2AQO DMN2AQO DN H-Tyr-D-Ala-(R or S)Atc-Asp-Val-Val-Gly-NH2 DMN2AQO MI TTKWM86 DMN2AQO MN Opioid receptor mu (MOP) DMN2AQO MT DTT DMN2AQO MA Inhibitor DMN2AQO RN Phe3-substituted analogues of deltorphin C. Spatial conformation and topography of the aromatic ring in peptide recognition by delta opioid receptors. J Med Chem. 1993 Nov 26;36(24):3748-56. DMN2AQO RU https://pubmed.ncbi.nlm.nih.gov/8254604 DM6ZHWS DI DM6ZHWS DM6ZHWS DN H-Tyr-D-Ala-Aic-Asp-Val-Val-Gly-NH2 DM6ZHWS MI TTKWM86 DM6ZHWS MN Opioid receptor mu (MOP) DM6ZHWS MT DTT DM6ZHWS MA Inhibitor DM6ZHWS RN Phe3-substituted analogues of deltorphin C. Spatial conformation and topography of the aromatic ring in peptide recognition by delta opioid receptors. J Med Chem. 1993 Nov 26;36(24):3748-56. DM6ZHWS RU https://pubmed.ncbi.nlm.nih.gov/8254604 DMDF9AS DI DMDF9AS DMDF9AS DN H-Tyr-D-Ala-Gly Phe-Pro-Leu-Trp-O-3,5-Bzl(CF3)2 DMDF9AS MI TT27RFC DMDF9AS MN Opioid receptor delta (OPRD1) DMDF9AS MT DTT DMDF9AS MA Inhibitor DMDF9AS RN A structure-activity relationship study and combinatorial synthetic approach of C-terminal modified bifunctional peptides that are delta/mu opioid ... J Med Chem. 2008 Mar 13;51(5):1369-76. DMDF9AS RU https://pubmed.ncbi.nlm.nih.gov/18266313 DMDF9AS DI DMDF9AS DMDF9AS DN H-Tyr-D-Ala-Gly Phe-Pro-Leu-Trp-O-3,5-Bzl(CF3)2 DMDF9AS MI TTKWM86 DMDF9AS MN Opioid receptor mu (MOP) DMDF9AS MT DTT DMDF9AS MA Inhibitor DMDF9AS RN A structure-activity relationship study and combinatorial synthetic approach of C-terminal modified bifunctional peptides that are delta/mu opioid ... J Med Chem. 2008 Mar 13;51(5):1369-76. DMDF9AS RU https://pubmed.ncbi.nlm.nih.gov/18266313 DMDF9AS DI DMDF9AS DMDF9AS DN H-Tyr-D-Ala-Gly Phe-Pro-Leu-Trp-O-3,5-Bzl(CF3)2 DMDF9AS MI TTZPO1L DMDF9AS MN Substance-P receptor (TACR1) DMDF9AS MT DTT DMDF9AS MA Inhibitor DMDF9AS RN A structure-activity relationship study and combinatorial synthetic approach of C-terminal modified bifunctional peptides that are delta/mu opioid ... J Med Chem. 2008 Mar 13;51(5):1369-76. DMDF9AS RU https://pubmed.ncbi.nlm.nih.gov/18266313 DM4VBDW DI DM4VBDW DM4VBDW DN H-Tyr-D-Ala-Gly-Phe-NH-NH-(NMe)Phe-Asp-Nle-Trp-Ac DM4VBDW MI TT27RFC DM4VBDW MN Opioid receptor delta (OPRD1) DM4VBDW MT DTT DM4VBDW MA Inhibitor DM4VBDW RN Design and synthesis of novel hydrazide-linked bifunctional peptides as delta/mu opioid receptor agonists and CCK-1/CCK-2 receptor antagonists. J Med Chem. 2006 Mar 9;49(5):1773-80. DM4VBDW RU https://pubmed.ncbi.nlm.nih.gov/16509592 DM4VBDW DI DM4VBDW DM4VBDW DN H-Tyr-D-Ala-Gly-Phe-NH-NH-(NMe)Phe-Asp-Nle-Trp-Ac DM4VBDW MI TTKWM86 DM4VBDW MN Opioid receptor mu (MOP) DM4VBDW MT DTT DM4VBDW MA Inhibitor DM4VBDW RN Design and synthesis of novel hydrazide-linked bifunctional peptides as delta/mu opioid receptor agonists and CCK-1/CCK-2 receptor antagonists. J Med Chem. 2006 Mar 9;49(5):1773-80. DM4VBDW RU https://pubmed.ncbi.nlm.nih.gov/16509592 DM0J8P6 DI DM0J8P6 DM0J8P6 DN H-Tyr-D-Ala-Gly-Phe-NH-NH-D-Phe-D-Asp-D-Nle-Trp-H DM0J8P6 MI TT27RFC DM0J8P6 MN Opioid receptor delta (OPRD1) DM0J8P6 MT DTT DM0J8P6 MA Inhibitor DM0J8P6 RN Partial retro-inverso, retro, and inverso modifications of hydrazide linked bifunctional peptides for opioid and cholecystokinin (CCK) receptors. J Med Chem. 2007 Jan 11;50(1):165-8. DM0J8P6 RU https://pubmed.ncbi.nlm.nih.gov/17201419 DM0J8P6 DI DM0J8P6 DM0J8P6 DN H-Tyr-D-Ala-Gly-Phe-NH-NH-D-Phe-D-Asp-D-Nle-Trp-H DM0J8P6 MI TTKWM86 DM0J8P6 MN Opioid receptor mu (MOP) DM0J8P6 MT DTT DM0J8P6 MA Inhibitor DM0J8P6 RN Partial retro-inverso, retro, and inverso modifications of hydrazide linked bifunctional peptides for opioid and cholecystokinin (CCK) receptors. J Med Chem. 2007 Jan 11;50(1):165-8. DM0J8P6 RU https://pubmed.ncbi.nlm.nih.gov/17201419 DMW50ZQ DI DMW50ZQ DMW50ZQ DN H-Tyr-D-Ala-Gly-Phe-NH-NH-D-Trp-Nle-Asp-Phe-Bo DMW50ZQ MI TTVFO0U DMW50ZQ MN Gastrin/cholecystokinin type B receptor (CCKBR) DMW50ZQ MT DTT DMW50ZQ MA Inhibitor DMW50ZQ RN Partial retro-inverso, retro, and inverso modifications of hydrazide linked bifunctional peptides for opioid and cholecystokinin (CCK) receptors. J Med Chem. 2007 Jan 11;50(1):165-8. DMW50ZQ RU https://pubmed.ncbi.nlm.nih.gov/17201419 DMW50ZQ DI DMW50ZQ DMW50ZQ DN H-Tyr-D-Ala-Gly-Phe-NH-NH-D-Trp-Nle-Asp-Phe-Bo DMW50ZQ MI TT27RFC DMW50ZQ MN Opioid receptor delta (OPRD1) DMW50ZQ MT DTT DMW50ZQ MA Inhibitor DMW50ZQ RN Partial retro-inverso, retro, and inverso modifications of hydrazide linked bifunctional peptides for opioid and cholecystokinin (CCK) receptors. J Med Chem. 2007 Jan 11;50(1):165-8. DMW50ZQ RU https://pubmed.ncbi.nlm.nih.gov/17201419 DMW50ZQ DI DMW50ZQ DMW50ZQ DN H-Tyr-D-Ala-Gly-Phe-NH-NH-D-Trp-Nle-Asp-Phe-Bo DMW50ZQ MI TTKWM86 DMW50ZQ MN Opioid receptor mu (MOP) DMW50ZQ MT DTT DMW50ZQ MA Inhibitor DMW50ZQ RN Partial retro-inverso, retro, and inverso modifications of hydrazide linked bifunctional peptides for opioid and cholecystokinin (CCK) receptors. J Med Chem. 2007 Jan 11;50(1):165-8. DMW50ZQ RU https://pubmed.ncbi.nlm.nih.gov/17201419 DMF82C1 DI DMF82C1 DMF82C1 DN H-Tyr-D-Ala-Gly-Phe-NH-NH-D-Trp-Nle-Asp-Phe-H DMF82C1 MI TTCG0AL DMF82C1 MN Cholecystokinin receptor type A (CCKAR) DMF82C1 MT DTT DMF82C1 MA Inhibitor DMF82C1 RN Partial retro-inverso, retro, and inverso modifications of hydrazide linked bifunctional peptides for opioid and cholecystokinin (CCK) receptors. J Med Chem. 2007 Jan 11;50(1):165-8. DMF82C1 RU https://pubmed.ncbi.nlm.nih.gov/17201419 DMF82C1 DI DMF82C1 DMF82C1 DN H-Tyr-D-Ala-Gly-Phe-NH-NH-D-Trp-Nle-Asp-Phe-H DMF82C1 MI TTVFO0U DMF82C1 MN Gastrin/cholecystokinin type B receptor (CCKBR) DMF82C1 MT DTT DMF82C1 MA Inhibitor DMF82C1 RN Partial retro-inverso, retro, and inverso modifications of hydrazide linked bifunctional peptides for opioid and cholecystokinin (CCK) receptors. J Med Chem. 2007 Jan 11;50(1):165-8. DMF82C1 RU https://pubmed.ncbi.nlm.nih.gov/17201419 DMF82C1 DI DMF82C1 DMF82C1 DN H-Tyr-D-Ala-Gly-Phe-NH-NH-D-Trp-Nle-Asp-Phe-H DMF82C1 MI TT27RFC DMF82C1 MN Opioid receptor delta (OPRD1) DMF82C1 MT DTT DMF82C1 MA Inhibitor DMF82C1 RN Partial retro-inverso, retro, and inverso modifications of hydrazide linked bifunctional peptides for opioid and cholecystokinin (CCK) receptors. J Med Chem. 2007 Jan 11;50(1):165-8. DMF82C1 RU https://pubmed.ncbi.nlm.nih.gov/17201419 DMF82C1 DI DMF82C1 DMF82C1 DN H-Tyr-D-Ala-Gly-Phe-NH-NH-D-Trp-Nle-Asp-Phe-H DMF82C1 MI TTKWM86 DMF82C1 MN Opioid receptor mu (MOP) DMF82C1 MT DTT DMF82C1 MA Inhibitor DMF82C1 RN Partial retro-inverso, retro, and inverso modifications of hydrazide linked bifunctional peptides for opioid and cholecystokinin (CCK) receptors. J Med Chem. 2007 Jan 11;50(1):165-8. DMF82C1 RU https://pubmed.ncbi.nlm.nih.gov/17201419 DM6UWKL DI DM6UWKL DM6UWKL DN H-Tyr-D-Ala-Gly-Phe-NH-NH-Phe-Asp-Nle-D-Trp-Boc DM6UWKL MI TT27RFC DM6UWKL MN Opioid receptor delta (OPRD1) DM6UWKL MT DTT DM6UWKL MA Inhibitor DM6UWKL RN Design and synthesis of novel hydrazide-linked bifunctional peptides as delta/mu opioid receptor agonists and CCK-1/CCK-2 receptor antagonists. J Med Chem. 2006 Mar 9;49(5):1773-80. DM6UWKL RU https://pubmed.ncbi.nlm.nih.gov/16509592 DM6UWKL DI DM6UWKL DM6UWKL DN H-Tyr-D-Ala-Gly-Phe-NH-NH-Phe-Asp-Nle-D-Trp-Boc DM6UWKL MI TTKWM86 DM6UWKL MN Opioid receptor mu (MOP) DM6UWKL MT DTT DM6UWKL MA Inhibitor DM6UWKL RN Design and synthesis of novel hydrazide-linked bifunctional peptides as delta/mu opioid receptor agonists and CCK-1/CCK-2 receptor antagonists. J Med Chem. 2006 Mar 9;49(5):1773-80. DM6UWKL RU https://pubmed.ncbi.nlm.nih.gov/16509592 DMSXD63 DI DMSXD63 DMSXD63 DN H-Tyr-D-Ala-Gly-Phe-NH-NH-Phe-Asp-Nle-D-Trp-H DMSXD63 MI TTCG0AL DMSXD63 MN Cholecystokinin receptor type A (CCKAR) DMSXD63 MT DTT DMSXD63 MA Inhibitor DMSXD63 RN Design and synthesis of novel hydrazide-linked bifunctional peptides as delta/mu opioid receptor agonists and CCK-1/CCK-2 receptor antagonists. J Med Chem. 2006 Mar 9;49(5):1773-80. DMSXD63 RU https://pubmed.ncbi.nlm.nih.gov/16509592 DMSXD63 DI DMSXD63 DMSXD63 DN H-Tyr-D-Ala-Gly-Phe-NH-NH-Phe-Asp-Nle-D-Trp-H DMSXD63 MI TTVFO0U DMSXD63 MN Gastrin/cholecystokinin type B receptor (CCKBR) DMSXD63 MT DTT DMSXD63 MA Inhibitor DMSXD63 RN Design and synthesis of novel hydrazide-linked bifunctional peptides as delta/mu opioid receptor agonists and CCK-1/CCK-2 receptor antagonists. J Med Chem. 2006 Mar 9;49(5):1773-80. DMSXD63 RU https://pubmed.ncbi.nlm.nih.gov/16509592 DMSXD63 DI DMSXD63 DMSXD63 DN H-Tyr-D-Ala-Gly-Phe-NH-NH-Phe-Asp-Nle-D-Trp-H DMSXD63 MI TT27RFC DMSXD63 MN Opioid receptor delta (OPRD1) DMSXD63 MT DTT DMSXD63 MA Inhibitor DMSXD63 RN Design and synthesis of novel hydrazide-linked bifunctional peptides as delta/mu opioid receptor agonists and CCK-1/CCK-2 receptor antagonists. J Med Chem. 2006 Mar 9;49(5):1773-80. DMSXD63 RU https://pubmed.ncbi.nlm.nih.gov/16509592 DMSXD63 DI DMSXD63 DMSXD63 DN H-Tyr-D-Ala-Gly-Phe-NH-NH-Phe-Asp-Nle-D-Trp-H DMSXD63 MI TTKWM86 DMSXD63 MN Opioid receptor mu (MOP) DMSXD63 MT DTT DMSXD63 MA Inhibitor DMSXD63 RN Design and synthesis of novel hydrazide-linked bifunctional peptides as delta/mu opioid receptor agonists and CCK-1/CCK-2 receptor antagonists. J Med Chem. 2006 Mar 9;49(5):1773-80. DMSXD63 RU https://pubmed.ncbi.nlm.nih.gov/16509592 DMRUD37 DI DMRUD37 DMRUD37 DN H-Tyr-D-Ala-Gly-Phe-NH-NH-Phe-Asp-Nle-Trp-Ac DMRUD37 MI TTVFO0U DMRUD37 MN Gastrin/cholecystokinin type B receptor (CCKBR) DMRUD37 MT DTT DMRUD37 MA Inhibitor DMRUD37 RN Design and synthesis of novel hydrazide-linked bifunctional peptides as delta/mu opioid receptor agonists and CCK-1/CCK-2 receptor antagonists. J Med Chem. 2006 Mar 9;49(5):1773-80. DMRUD37 RU https://pubmed.ncbi.nlm.nih.gov/16509592 DMRUD37 DI DMRUD37 DMRUD37 DN H-Tyr-D-Ala-Gly-Phe-NH-NH-Phe-Asp-Nle-Trp-Ac DMRUD37 MI TT27RFC DMRUD37 MN Opioid receptor delta (OPRD1) DMRUD37 MT DTT DMRUD37 MA Inhibitor DMRUD37 RN Design and synthesis of novel hydrazide-linked bifunctional peptides as delta/mu opioid receptor agonists and CCK-1/CCK-2 receptor antagonists. J Med Chem. 2006 Mar 9;49(5):1773-80. DMRUD37 RU https://pubmed.ncbi.nlm.nih.gov/16509592 DMRUD37 DI DMRUD37 DMRUD37 DN H-Tyr-D-Ala-Gly-Phe-NH-NH-Phe-Asp-Nle-Trp-Ac DMRUD37 MI TTKWM86 DMRUD37 MN Opioid receptor mu (MOP) DMRUD37 MT DTT DMRUD37 MA Inhibitor DMRUD37 RN Design and synthesis of novel hydrazide-linked bifunctional peptides as delta/mu opioid receptor agonists and CCK-1/CCK-2 receptor antagonists. J Med Chem. 2006 Mar 9;49(5):1773-80. DMRUD37 RU https://pubmed.ncbi.nlm.nih.gov/16509592 DMIPXCZ DI DMIPXCZ DMIPXCZ DN H-Tyr-D-Ala-Gly-Phe-NH-NH-Phe-Asp-Nle-Trp-Boc DMIPXCZ MI TTCG0AL DMIPXCZ MN Cholecystokinin receptor type A (CCKAR) DMIPXCZ MT DTT DMIPXCZ MA Inhibitor DMIPXCZ RN Design and synthesis of novel hydrazide-linked bifunctional peptides as delta/mu opioid receptor agonists and CCK-1/CCK-2 receptor antagonists. J Med Chem. 2006 Mar 9;49(5):1773-80. DMIPXCZ RU https://pubmed.ncbi.nlm.nih.gov/16509592 DMIPXCZ DI DMIPXCZ DMIPXCZ DN H-Tyr-D-Ala-Gly-Phe-NH-NH-Phe-Asp-Nle-Trp-Boc DMIPXCZ MI TTVFO0U DMIPXCZ MN Gastrin/cholecystokinin type B receptor (CCKBR) DMIPXCZ MT DTT DMIPXCZ MA Inhibitor DMIPXCZ RN Design and synthesis of novel hydrazide-linked bifunctional peptides as delta/mu opioid receptor agonists and CCK-1/CCK-2 receptor antagonists. J Med Chem. 2006 Mar 9;49(5):1773-80. DMIPXCZ RU https://pubmed.ncbi.nlm.nih.gov/16509592 DMIPXCZ DI DMIPXCZ DMIPXCZ DN H-Tyr-D-Ala-Gly-Phe-NH-NH-Phe-Asp-Nle-Trp-Boc DMIPXCZ MI TT27RFC DMIPXCZ MN Opioid receptor delta (OPRD1) DMIPXCZ MT DTT DMIPXCZ MA Inhibitor DMIPXCZ RN Design and synthesis of novel hydrazide-linked bifunctional peptides as delta/mu opioid receptor agonists and CCK-1/CCK-2 receptor antagonists. J Med Chem. 2006 Mar 9;49(5):1773-80. DMIPXCZ RU https://pubmed.ncbi.nlm.nih.gov/16509592 DMIPXCZ DI DMIPXCZ DMIPXCZ DN H-Tyr-D-Ala-Gly-Phe-NH-NH-Phe-Asp-Nle-Trp-Boc DMIPXCZ MI TTKWM86 DMIPXCZ MN Opioid receptor mu (MOP) DMIPXCZ MT DTT DMIPXCZ MA Inhibitor DMIPXCZ RN Design and synthesis of novel hydrazide-linked bifunctional peptides as delta/mu opioid receptor agonists and CCK-1/CCK-2 receptor antagonists. J Med Chem. 2006 Mar 9;49(5):1773-80. DMIPXCZ RU https://pubmed.ncbi.nlm.nih.gov/16509592 DMFSKDM DI DMFSKDM DMFSKDM DN H-Tyr-D-Ala-Gly-Phe-NH-NH-Trp-D-Nle-D-Asp-D-Phe-H DMFSKDM MI TTCG0AL DMFSKDM MN Cholecystokinin receptor type A (CCKAR) DMFSKDM MT DTT DMFSKDM MA Inhibitor DMFSKDM RN Partial retro-inverso, retro, and inverso modifications of hydrazide linked bifunctional peptides for opioid and cholecystokinin (CCK) receptors. J Med Chem. 2007 Jan 11;50(1):165-8. DMFSKDM RU https://pubmed.ncbi.nlm.nih.gov/17201419 DMFSKDM DI DMFSKDM DMFSKDM DN H-Tyr-D-Ala-Gly-Phe-NH-NH-Trp-D-Nle-D-Asp-D-Phe-H DMFSKDM MI TT27RFC DMFSKDM MN Opioid receptor delta (OPRD1) DMFSKDM MT DTT DMFSKDM MA Inhibitor DMFSKDM RN Partial retro-inverso, retro, and inverso modifications of hydrazide linked bifunctional peptides for opioid and cholecystokinin (CCK) receptors. J Med Chem. 2007 Jan 11;50(1):165-8. DMFSKDM RU https://pubmed.ncbi.nlm.nih.gov/17201419 DMFSKDM DI DMFSKDM DMFSKDM DN H-Tyr-D-Ala-Gly-Phe-NH-NH-Trp-D-Nle-D-Asp-D-Phe-H DMFSKDM MI TTKWM86 DMFSKDM MN Opioid receptor mu (MOP) DMFSKDM MT DTT DMFSKDM MA Inhibitor DMFSKDM RN Partial retro-inverso, retro, and inverso modifications of hydrazide linked bifunctional peptides for opioid and cholecystokinin (CCK) receptors. J Med Chem. 2007 Jan 11;50(1):165-8. DMFSKDM RU https://pubmed.ncbi.nlm.nih.gov/17201419 DM2K16M DI DM2K16M DM2K16M DN H-Tyr-D-Ala-Gly-Phe-Pro-Leu-Trp-NH-3,5-Bzl(CF3)2 DM2K16M MI TT27RFC DM2K16M MN Opioid receptor delta (OPRD1) DM2K16M MT DTT DM2K16M MA Inhibitor DM2K16M RN A structure-activity relationship study and combinatorial synthetic approach of C-terminal modified bifunctional peptides that are delta/mu opioid ... J Med Chem. 2008 Mar 13;51(5):1369-76. DM2K16M RU https://pubmed.ncbi.nlm.nih.gov/18266313 DM2K16M DI DM2K16M DM2K16M DN H-Tyr-D-Ala-Gly-Phe-Pro-Leu-Trp-NH-3,5-Bzl(CF3)2 DM2K16M MI TTKWM86 DM2K16M MN Opioid receptor mu (MOP) DM2K16M MT DTT DM2K16M MA Inhibitor DM2K16M RN A structure-activity relationship study and combinatorial synthetic approach of C-terminal modified bifunctional peptides that are delta/mu opioid ... J Med Chem. 2008 Mar 13;51(5):1369-76. DM2K16M RU https://pubmed.ncbi.nlm.nih.gov/18266313 DM2K16M DI DM2K16M DM2K16M DN H-Tyr-D-Ala-Gly-Phe-Pro-Leu-Trp-NH-3,5-Bzl(CF3)2 DM2K16M MI TTZPO1L DM2K16M MN Substance-P receptor (TACR1) DM2K16M MT DTT DM2K16M MA Inhibitor DM2K16M RN A structure-activity relationship study and combinatorial synthetic approach of C-terminal modified bifunctional peptides that are delta/mu opioid ... J Med Chem. 2008 Mar 13;51(5):1369-76. DM2K16M RU https://pubmed.ncbi.nlm.nih.gov/18266313 DMRE4ZI DI DMRE4ZI DMRE4ZI DN H-Tyr-D-Ala-Gly-Phe-Pro-Leu-Trp-NH-Bzl DMRE4ZI MI TT27RFC DMRE4ZI MN Opioid receptor delta (OPRD1) DMRE4ZI MT DTT DMRE4ZI MA Inhibitor DMRE4ZI RN A structure-activity relationship study and combinatorial synthetic approach of C-terminal modified bifunctional peptides that are delta/mu opioid ... J Med Chem. 2008 Mar 13;51(5):1369-76. DMRE4ZI RU https://pubmed.ncbi.nlm.nih.gov/18266313 DMRE4ZI DI DMRE4ZI DMRE4ZI DN H-Tyr-D-Ala-Gly-Phe-Pro-Leu-Trp-NH-Bzl DMRE4ZI MI TTKWM86 DMRE4ZI MN Opioid receptor mu (MOP) DMRE4ZI MT DTT DMRE4ZI MA Inhibitor DMRE4ZI RN A structure-activity relationship study and combinatorial synthetic approach of C-terminal modified bifunctional peptides that are delta/mu opioid ... J Med Chem. 2008 Mar 13;51(5):1369-76. DMRE4ZI RU https://pubmed.ncbi.nlm.nih.gov/18266313 DMRE4ZI DI DMRE4ZI DMRE4ZI DN H-Tyr-D-Ala-Gly-Phe-Pro-Leu-Trp-NH-Bzl DMRE4ZI MI TTZPO1L DMRE4ZI MN Substance-P receptor (TACR1) DMRE4ZI MT DTT DMRE4ZI MA Inhibitor DMRE4ZI RN A structure-activity relationship study and combinatorial synthetic approach of C-terminal modified bifunctional peptides that are delta/mu opioid ... J Med Chem. 2008 Mar 13;51(5):1369-76. DMRE4ZI RU https://pubmed.ncbi.nlm.nih.gov/18266313 DM1ESMZ DI DM1ESMZ DM1ESMZ DN H-Tyr-D-Ala-Gly-Phe-Pro-Leu-Trp-NMe-3,5-Bzl(CF3)2 DM1ESMZ MI TT27RFC DM1ESMZ MN Opioid receptor delta (OPRD1) DM1ESMZ MT DTT DM1ESMZ MA Inhibitor DM1ESMZ RN A structure-activity relationship study and combinatorial synthetic approach of C-terminal modified bifunctional peptides that are delta/mu opioid ... J Med Chem. 2008 Mar 13;51(5):1369-76. DM1ESMZ RU https://pubmed.ncbi.nlm.nih.gov/18266313 DM1ESMZ DI DM1ESMZ DM1ESMZ DN H-Tyr-D-Ala-Gly-Phe-Pro-Leu-Trp-NMe-3,5-Bzl(CF3)2 DM1ESMZ MI TTKWM86 DM1ESMZ MN Opioid receptor mu (MOP) DM1ESMZ MT DTT DM1ESMZ MA Inhibitor DM1ESMZ RN A structure-activity relationship study and combinatorial synthetic approach of C-terminal modified bifunctional peptides that are delta/mu opioid ... J Med Chem. 2008 Mar 13;51(5):1369-76. DM1ESMZ RU https://pubmed.ncbi.nlm.nih.gov/18266313 DM1ESMZ DI DM1ESMZ DM1ESMZ DN H-Tyr-D-Ala-Gly-Phe-Pro-Leu-Trp-NMe-3,5-Bzl(CF3)2 DM1ESMZ MI TTZPO1L DM1ESMZ MN Substance-P receptor (TACR1) DM1ESMZ MT DTT DM1ESMZ MA Inhibitor DM1ESMZ RN A structure-activity relationship study and combinatorial synthetic approach of C-terminal modified bifunctional peptides that are delta/mu opioid ... J Med Chem. 2008 Mar 13;51(5):1369-76. DM1ESMZ RU https://pubmed.ncbi.nlm.nih.gov/18266313 DM56KDV DI DM56KDV DM56KDV DN H-Tyr-D-Ala-Gly-Phe-Pro-Leu-Trp-NMe-Bzl DM56KDV MI TT27RFC DM56KDV MN Opioid receptor delta (OPRD1) DM56KDV MT DTT DM56KDV MA Inhibitor DM56KDV RN A structure-activity relationship study and combinatorial synthetic approach of C-terminal modified bifunctional peptides that are delta/mu opioid ... J Med Chem. 2008 Mar 13;51(5):1369-76. DM56KDV RU https://pubmed.ncbi.nlm.nih.gov/18266313 DM56KDV DI DM56KDV DM56KDV DN H-Tyr-D-Ala-Gly-Phe-Pro-Leu-Trp-NMe-Bzl DM56KDV MI TTKWM86 DM56KDV MN Opioid receptor mu (MOP) DM56KDV MT DTT DM56KDV MA Inhibitor DM56KDV RN A structure-activity relationship study and combinatorial synthetic approach of C-terminal modified bifunctional peptides that are delta/mu opioid ... J Med Chem. 2008 Mar 13;51(5):1369-76. DM56KDV RU https://pubmed.ncbi.nlm.nih.gov/18266313 DM56KDV DI DM56KDV DM56KDV DN H-Tyr-D-Ala-Gly-Phe-Pro-Leu-Trp-NMe-Bzl DM56KDV MI TTZPO1L DM56KDV MN Substance-P receptor (TACR1) DM56KDV MT DTT DM56KDV MA Inhibitor DM56KDV RN A structure-activity relationship study and combinatorial synthetic approach of C-terminal modified bifunctional peptides that are delta/mu opioid ... J Med Chem. 2008 Mar 13;51(5):1369-76. DM56KDV RU https://pubmed.ncbi.nlm.nih.gov/18266313 DMH3YKR DI DMH3YKR DMH3YKR DN H-Tyr-D-Ala-Gly-Phe-Pro-Leu-Trp-O-Bzl DMH3YKR MI TT27RFC DMH3YKR MN Opioid receptor delta (OPRD1) DMH3YKR MT DTT DMH3YKR MA Inhibitor DMH3YKR RN A structure-activity relationship study and combinatorial synthetic approach of C-terminal modified bifunctional peptides that are delta/mu opioid ... J Med Chem. 2008 Mar 13;51(5):1369-76. DMH3YKR RU https://pubmed.ncbi.nlm.nih.gov/18266313 DMH3YKR DI DMH3YKR DMH3YKR DN H-Tyr-D-Ala-Gly-Phe-Pro-Leu-Trp-O-Bzl DMH3YKR MI TTKWM86 DMH3YKR MN Opioid receptor mu (MOP) DMH3YKR MT DTT DMH3YKR MA Inhibitor DMH3YKR RN A structure-activity relationship study and combinatorial synthetic approach of C-terminal modified bifunctional peptides that are delta/mu opioid ... J Med Chem. 2008 Mar 13;51(5):1369-76. DMH3YKR RU https://pubmed.ncbi.nlm.nih.gov/18266313 DMH3YKR DI DMH3YKR DMH3YKR DN H-Tyr-D-Ala-Gly-Phe-Pro-Leu-Trp-O-Bzl DMH3YKR MI TTZPO1L DMH3YKR MN Substance-P receptor (TACR1) DMH3YKR MT DTT DMH3YKR MA Inhibitor DMH3YKR RN A structure-activity relationship study and combinatorial synthetic approach of C-terminal modified bifunctional peptides that are delta/mu opioid ... J Med Chem. 2008 Mar 13;51(5):1369-76. DMH3YKR RU https://pubmed.ncbi.nlm.nih.gov/18266313 DMSX8CH DI DMSX8CH DMSX8CH DN H-Tyr-D-Ala-Tic-Asp-Val-Val-Gly-NH2 DMSX8CH MI TTKWM86 DMSX8CH MN Opioid receptor mu (MOP) DMSX8CH MT DTT DMSX8CH MA Inhibitor DMSX8CH RN Phe3-substituted analogues of deltorphin C. Spatial conformation and topography of the aromatic ring in peptide recognition by delta opioid receptors. J Med Chem. 1993 Nov 26;36(24):3748-56. DMSX8CH RU https://pubmed.ncbi.nlm.nih.gov/8254604 DM25KZE DI DM25KZE DM25KZE DN HTyr-Gly-Gly-Phe-Leu-Arg-Arg-lle-Arg-Pro-LysNH2 DM25KZE MI TT27RFC DM25KZE MN Opioid receptor delta (OPRD1) DM25KZE MT DTT DM25KZE MA Inhibitor DM25KZE RN The effects of C-terminal modifications on the opioid activity of [N-benzylTyr(1)]dynorphin A-(1-11) analogues. J Med Chem. 2009 Nov 12;52(21):6814-21. DM25KZE RU https://pubmed.ncbi.nlm.nih.gov/19807094 DM25KZE DI DM25KZE DM25KZE DN HTyr-Gly-Gly-Phe-Leu-Arg-Arg-lle-Arg-Pro-LysNH2 DM25KZE MI TTQW87Y DM25KZE MN Opioid receptor kappa (OPRK1) DM25KZE MT DTT DM25KZE MA Inhibitor DM25KZE RN The effects of C-terminal modifications on the opioid activity of [N-benzylTyr(1)]dynorphin A-(1-11) analogues. J Med Chem. 2009 Nov 12;52(21):6814-21. DM25KZE RU https://pubmed.ncbi.nlm.nih.gov/19807094 DM25KZE DI DM25KZE DM25KZE DN HTyr-Gly-Gly-Phe-Leu-Arg-Arg-lle-Arg-Pro-LysNH2 DM25KZE MI TTKWM86 DM25KZE MN Opioid receptor mu (MOP) DM25KZE MT DTT DM25KZE MA Inhibitor DM25KZE RN The effects of C-terminal modifications on the opioid activity of [N-benzylTyr(1)]dynorphin A-(1-11) analogues. J Med Chem. 2009 Nov 12;52(21):6814-21. DM25KZE RU https://pubmed.ncbi.nlm.nih.gov/19807094 DM6D0ZS DI DM6D0ZS DM6D0ZS DN H-Tyr-Gly-Gly-Phe-Met-NH2 DM6D0ZS MI TT27RFC DM6D0ZS MN Opioid receptor delta (OPRD1) DM6D0ZS MT DTT DM6D0ZS MA Inhibitor DM6D0ZS RN Further studies of tyrosine surrogates in opioid receptor peptide ligands. Bioorg Med Chem Lett. 2007 May 1;17(9):2656-60. DM6D0ZS RU https://pubmed.ncbi.nlm.nih.gov/17350835 DM6D0ZS DI DM6D0ZS DM6D0ZS DN H-Tyr-Gly-Gly-Phe-Met-NH2 DM6D0ZS MI TTQW87Y DM6D0ZS MN Opioid receptor kappa (OPRK1) DM6D0ZS MT DTT DM6D0ZS MA Inhibitor DM6D0ZS RN Further studies of tyrosine surrogates in opioid receptor peptide ligands. Bioorg Med Chem Lett. 2007 May 1;17(9):2656-60. DM6D0ZS RU https://pubmed.ncbi.nlm.nih.gov/17350835 DM6D0ZS DI DM6D0ZS DM6D0ZS DN H-Tyr-Gly-Gly-Phe-Met-NH2 DM6D0ZS MI TTKWM86 DM6D0ZS MN Opioid receptor mu (MOP) DM6D0ZS MT DTT DM6D0ZS MA Inhibitor DM6D0ZS RN Further studies of tyrosine surrogates in opioid receptor peptide ligands. Bioorg Med Chem Lett. 2007 May 1;17(9):2656-60. DM6D0ZS RU https://pubmed.ncbi.nlm.nih.gov/17350835 DM1NT5G DI DM1NT5G DM1NT5G DN H-Tyr-NMe-D-Ala-Phe-Sar-NH2 DM1NT5G MI TT27RFC DM1NT5G MN Opioid receptor delta (OPRD1) DM1NT5G MT DTT DM1NT5G MA Inhibitor DM1NT5G RN Blood-brain barrier penetration by two dermorphin tetrapeptide analogues: role of lipophilicity vs structural flexibility. J Med Chem. 2008 Apr 24;51(8):2571-4. DM1NT5G RU https://pubmed.ncbi.nlm.nih.gov/18370374 DMP0CRD DI DMP0CRD DMP0CRD DN H-Tyr-Pro-Ala-Phe-NH2 DMP0CRD MI TTKWM86 DMP0CRD MN Opioid receptor mu (MOP) DMP0CRD MT DTT DMP0CRD MA Inhibitor DMP0CRD RN Internalisation of the mu-opioid receptor by endomorphin-1 and leu-enkephalin is dependant on aromatic amino acid residues. Bioorg Med Chem. 2008 Apr 15;16(8):4341-6. DMP0CRD RU https://pubmed.ncbi.nlm.nih.gov/18329886 DMP0CRD DI DMP0CRD DMP0CRD DN H-Tyr-Pro-Ala-Phe-NH2 DMP0CRD MI TTZPO1L DMP0CRD MN Substance-P receptor (TACR1) DMP0CRD MT DTT DMP0CRD MA Inhibitor DMP0CRD RN Discovery of dipeptides with high affinity to the specific binding site for substance P1-7. J Med Chem. 2010 Mar 25;53(6):2383-9. DMP0CRD RU https://pubmed.ncbi.nlm.nih.gov/20178322 DMQUNGC DI DMQUNGC DMQUNGC DN H-Tyr-Pro-Dap(6DMN)-Phe-NH2 DMQUNGC MI TT27RFC DMQUNGC MN Opioid receptor delta (OPRD1) DMQUNGC MT DTT DMQUNGC MA Inhibitor DMQUNGC RN 6-N,N-dimethylamino-2,3-naphthalimide: a new environment-sensitive fluorescent probe in delta- and mu-selective opioid peptides. J Med Chem. 2006 Jun 15;49(12):3653-8. DMQUNGC RU https://pubmed.ncbi.nlm.nih.gov/16759107 DMQUNGC DI DMQUNGC DMQUNGC DN H-Tyr-Pro-Dap(6DMN)-Phe-NH2 DMQUNGC MI TTKWM86 DMQUNGC MN Opioid receptor mu (MOP) DMQUNGC MT DTT DMQUNGC MA Inhibitor DMQUNGC RN 6-N,N-dimethylamino-2,3-naphthalimide: a new environment-sensitive fluorescent probe in delta- and mu-selective opioid peptides. J Med Chem. 2006 Jun 15;49(12):3653-8. DMQUNGC RU https://pubmed.ncbi.nlm.nih.gov/16759107 DM2F6L9 DI DM2F6L9 DM2F6L9 DN H-Tyr-Pro-Phe-Ala-NH2 DM2F6L9 MI TTZPO1L DM2F6L9 MN Substance-P receptor (TACR1) DM2F6L9 MT DTT DM2F6L9 MA Inhibitor DM2F6L9 RN Discovery of dipeptides with high affinity to the specific binding site for substance P1-7. J Med Chem. 2010 Mar 25;53(6):2383-9. DM2F6L9 RU https://pubmed.ncbi.nlm.nih.gov/20178322 DM326GJ DI DM326GJ DM326GJ DN H-Tyr-Pro-Phe-Phe-NH-(CH2)5-(C=O)-Dap(6DMN)-NH2 DM326GJ MI TT27RFC DM326GJ MN Opioid receptor delta (OPRD1) DM326GJ MT DTT DM326GJ MA Inhibitor DM326GJ RN 6-N,N-dimethylamino-2,3-naphthalimide: a new environment-sensitive fluorescent probe in delta- and mu-selective opioid peptides. J Med Chem. 2006 Jun 15;49(12):3653-8. DM326GJ RU https://pubmed.ncbi.nlm.nih.gov/16759107 DM326GJ DI DM326GJ DM326GJ DN H-Tyr-Pro-Phe-Phe-NH-(CH2)5-(C=O)-Dap(6DMN)-NH2 DM326GJ MI TTKWM86 DM326GJ MN Opioid receptor mu (MOP) DM326GJ MT DTT DM326GJ MA Inhibitor DM326GJ RN 6-N,N-dimethylamino-2,3-naphthalimide: a new environment-sensitive fluorescent probe in delta- and mu-selective opioid peptides. J Med Chem. 2006 Jun 15;49(12):3653-8. DM326GJ RU https://pubmed.ncbi.nlm.nih.gov/16759107 DMXQUKJ DI DMXQUKJ DMXQUKJ DN H-Tyr-Pro-Phe-Phe-NH-CH2-CH2-NH Tic Dmt-H DMXQUKJ MI TT27RFC DMXQUKJ MN Opioid receptor delta (OPRD1) DMXQUKJ MT DTT DMXQUKJ MA Inhibitor DMXQUKJ RN A new opioid designed multiple ligand derived from the micro opioid agonist endomorphin-2 and the delta opioid antagonist pharmacophore Dmt-Tic. Bioorg Med Chem. 2007 Nov 15;15(22):6876-81. DMXQUKJ RU https://pubmed.ncbi.nlm.nih.gov/17851080 DMXQUKJ DI DMXQUKJ DMXQUKJ DN H-Tyr-Pro-Phe-Phe-NH-CH2-CH2-NH Tic Dmt-H DMXQUKJ MI TTKWM86 DMXQUKJ MN Opioid receptor mu (MOP) DMXQUKJ MT DTT DMXQUKJ MA Inhibitor DMXQUKJ RN A new opioid designed multiple ligand derived from the micro opioid agonist endomorphin-2 and the delta opioid antagonist pharmacophore Dmt-Tic. Bioorg Med Chem. 2007 Nov 15;15(22):6876-81. DMXQUKJ RU https://pubmed.ncbi.nlm.nih.gov/17851080 DMUQLRN DI DMUQLRN DMUQLRN DN H-Tyr-Pro-Phe-Phe-OH DMUQLRN MI TTZPO1L DMUQLRN MN Substance-P receptor (TACR1) DMUQLRN MT DTT DMUQLRN MA Inhibitor DMUQLRN RN Discovery of dipeptides with high affinity to the specific binding site for substance P1-7. J Med Chem. 2010 Mar 25;53(6):2383-9. DMUQLRN RU https://pubmed.ncbi.nlm.nih.gov/20178322 DM1VFLG DI DM1VFLG DM1VFLG DN H-Tyr-Tic-Cha-Phe-OH DM1VFLG MI TT27RFC DM1VFLG MN Opioid receptor delta (OPRD1) DM1VFLG MT DTT DM1VFLG MA Inhibitor DM1VFLG RN Beta-methyl substitution of cyclohexylalanine in Dmt-Tic-Cha-Phe peptides results in highly potent delta opioid antagonists. J Med Chem. 2007 Jan 25;50(2):328-33. DM1VFLG RU https://pubmed.ncbi.nlm.nih.gov/17228874 DM1VFLG DI DM1VFLG DM1VFLG DN H-Tyr-Tic-Cha-Phe-OH DM1VFLG MI TTKWM86 DM1VFLG MN Opioid receptor mu (MOP) DM1VFLG MT DTT DM1VFLG MA Inhibitor DM1VFLG RN Beta-methyl substitution of cyclohexylalanine in Dmt-Tic-Cha-Phe peptides results in highly potent delta opioid antagonists. J Med Chem. 2007 Jan 25;50(2):328-33. DM1VFLG RU https://pubmed.ncbi.nlm.nih.gov/17228874 DMIU52O DI DMIU52O DMIU52O DN H-Tyr-Tic-OH DMIU52O MI TT27RFC DMIU52O MN Opioid receptor delta (OPRD1) DMIU52O MT DTT DMIU52O MA Inhibitor DMIU52O RN Agonist vs antagonist behavior of delta opioid peptides containing novel phenylalanine analogues in place of Tyr(1). J Med Chem. 2009 Nov 12;52(21):6941-5. DMIU52O RU https://pubmed.ncbi.nlm.nih.gov/19827750 DMI0U87 DI DMI0U87 DMI0U87 DN H-Tyr-Tic-Phe-Phe-OH DMI0U87 MI TT27RFC DMI0U87 MN Opioid receptor delta (OPRD1) DMI0U87 MT DTT DMI0U87 MA Inhibitor DMI0U87 RN The TIPP opioid peptide family: development of delta antagonists, delta agonists, and mixed mu agonist/delta antagonists. Biopolymers. 1999;51(6):411-25. DMI0U87 RU https://pubmed.ncbi.nlm.nih.gov/10797230 DMI0U87 DI DMI0U87 DMI0U87 DN H-Tyr-Tic-Phe-Phe-OH DMI0U87 MI TTKWM86 DMI0U87 MN Opioid receptor mu (MOP) DMI0U87 MT DTT DMI0U87 MA Inhibitor DMI0U87 RN Beta-methyl substitution of cyclohexylalanine in Dmt-Tic-Cha-Phe peptides results in highly potent delta opioid antagonists. J Med Chem. 2007 Jan 25;50(2):328-33. DMI0U87 RU https://pubmed.ncbi.nlm.nih.gov/17228874 DM48F3D DI DM48F3D DM48F3D DN HU210 DM48F3D MI TT6OEDT DM48F3D MN Cannabinoid receptor 1 (CB1) DM48F3D MT DTT DM48F3D MA Agonist DM48F3D RN The endogenous cannabinoid system protects against colonic inflammation. J Clin Invest. 2004 Apr;113(8):1202-9. DM48F3D RU https://pubmed.ncbi.nlm.nih.gov/15085199 DMPLG4R DI DMPLG4R DMPLG4R DN HU-433 DMPLG4R MI TTMSFAW DMPLG4R MN Cannabinoid receptor 2 (CB2) DMPLG4R MT DTT DMPLG4R MA Activator DMPLG4R RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 57). DMPLG4R RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=57 DM8FLVH DI DM8FLVH DM8FLVH DN Human CD40 agonist ligand DM8FLVH MI TTN6Y9A DM8FLVH MN CD40L receptor (CD40) DM8FLVH MT DTT DM8FLVH MA Agonist DM8FLVH RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1874). DM8FLVH RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1874 DMFV5UL DI DMFV5UL DMFV5UL DN human monoclonal antibodies (GM-CSF) DMFV5UL MI TTNYZG2 DMFV5UL MN Granulocyte-macrophage colony-stimulating factor (CSF2) DMFV5UL MT DTT DMFV5UL MA Modulator DMFV5UL RN The ChEMBL database in 2017. Nucleic Acids Res. 2017 Jan 4;45(D1):D945-D954. DMFV5UL RU https://www.ncbi.nlm.nih.gov/pubmed/27899562 DMARY2Z DI DMARY2Z DMARY2Z DN Human recombinant factor VIIa DMARY2Z MI TTF0EGX DMARY2Z MN Coagulation factor VII (F7) DMARY2Z MT DTT DMARY2Z MA Modulator DMARY2Z RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2363). DMARY2Z RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2363 DMG1BYH DI DMG1BYH DMG1BYH DN Human recombinant factor VIII DMG1BYH MI TT1290U DMG1BYH MN Coagulation factor VIII (F8) DMG1BYH MT DTT DMG1BYH MA Modulator DMG1BYH RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2607). DMG1BYH RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2607 DM4FIZJ DI DM4FIZJ DM4FIZJ DN HuMax-CD38b DM4FIZJ MI TTPURFN DM4FIZJ MN Cyclic ADP-ribose hydrolase 1 (CD38) DM4FIZJ MT DTT DM4FIZJ MA Modulator DM4FIZJ RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2766). DM4FIZJ RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2766 DM8AG5R DI DM8AG5R DM8AG5R DN HuMax-cMet DM8AG5R MI TTNDSF4 DM8AG5R MN Proto-oncogene c-Met (MET) DM8AG5R MT DTT DM8AG5R RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1815). DM8AG5R RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1815 DMTPXB6 DI DMTPXB6 DMTPXB6 DN Huprine X DMTPXB6 MI TT1RS9F DMTPXB6 MN Acetylcholinesterase (AChE) DMTPXB6 MT DTT DMTPXB6 MA Inhibitor DMTPXB6 RN Exploiting protein fluctuations at the active-site gorge of human cholinesterases: further optimization of the design strategy to develop extremely... J Med Chem. 2008 Jun 12;51(11):3154-70. DMTPXB6 RU https://pubmed.ncbi.nlm.nih.gov/18479118 DMTPXB6 DI DMTPXB6 DMTPXB6 DN Huprine X DMTPXB6 MI TTEB0GD DMTPXB6 MN Cholinesterase (BCHE) DMTPXB6 MT DTT DMTPXB6 MA Inhibitor DMTPXB6 RN Discovery of huperzine A-tacrine hybrids as potent inhibitors of human cholinesterases targeting their midgorge recognition sites. J Med Chem. 2006 Jun 1;49(11):3421-5. DMTPXB6 RU https://pubmed.ncbi.nlm.nih.gov/16722663 DMYH0XQ DI DMYH0XQ DMYH0XQ DN Huprine Y DMYH0XQ MI TT1RS9F DMYH0XQ MN Acetylcholinesterase (AChE) DMYH0XQ MT DTT DMYH0XQ MA Inhibitor DMYH0XQ RN Synthesis and structure-activity relationship of Huprine derivatives as human acetylcholinesterase inhibitors. Bioorg Med Chem. 2009 Jul 1;17(13):4523-36. DMYH0XQ RU https://pubmed.ncbi.nlm.nih.gov/19473849 DMJ4ME7 DI DMJ4ME7 DMJ4ME7 DN Huprine-Tacrine Heterodimer DMJ4ME7 MI TT1RS9F DMJ4ME7 MN Acetylcholinesterase (AChE) DMJ4ME7 MT DTT DMJ4ME7 MA Inhibitor DMJ4ME7 RN Synthesis and pharmacological evaluation of huprine-tacrine heterodimers: subnanomolar dual binding site acetylcholinesterase inhibitors. J Med Chem. 2005 Mar 24;48(6):1701-4. DMJ4ME7 RU https://pubmed.ncbi.nlm.nih.gov/15771413 DMJ4ME7 DI DMJ4ME7 DMJ4ME7 DN Huprine-Tacrine Heterodimer DMJ4ME7 MI TTEB0GD DMJ4ME7 MN Cholinesterase (BCHE) DMJ4ME7 MT DTT DMJ4ME7 MA Inhibitor DMJ4ME7 RN Synthesis and pharmacological evaluation of huprine-tacrine heterodimers: subnanomolar dual binding site acetylcholinesterase inhibitors. J Med Chem. 2005 Mar 24;48(6):1701-4. DMJ4ME7 RU https://pubmed.ncbi.nlm.nih.gov/15771413 DM1D5F0 DI DM1D5F0 DM1D5F0 DN HwFwLL-NH2 DM1D5F0 MI TTWDC17 DM1D5F0 MN Growth hormone secretagogue receptor 1 (GHSR) DM1D5F0 MT DTT DM1D5F0 MA Inhibitor DM1D5F0 RN Identification of an efficacy switch region in the ghrelin receptor responsible for interchange between agonism and inverse agonism. J Biol Chem. 2007 May 25;282(21):15799-811. DM1D5F0 RU https://pubmed.ncbi.nlm.nih.gov/17371869 DMJ9KNU DI DMJ9KNU DMJ9KNU DN Hyacinthacine B3 DMJ9KNU MI TTA0OSE DMJ9KNU MN Lactase-phlorizin hydrolase (LCT) DMJ9KNU MT DTT DMJ9KNU MA Inhibitor DMJ9KNU RN New polyhydroxylated pyrrolidine, piperidine, and pyrrolizidine alkaloids from Scilla sibirica. J Nat Prod. 2002 Dec;65(12):1875-81. DMJ9KNU RU https://pubmed.ncbi.nlm.nih.gov/12502331 DMY5RDI DI DMY5RDI DMY5RDI DN HYDAMTIQ DMY5RDI MI TTVDSZ0 DMY5RDI MN Poly [ADP-ribose] polymerase 1 (PARP1) DMY5RDI MT DTT DMY5RDI MA Inhibitor DMY5RDI RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2771). DMY5RDI RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2771 DMOTXP1 DI DMOTXP1 DMOTXP1 DN Hydantocidin-5'-Monophosphate DMOTXP1 MI TTYQ4AE DMOTXP1 MN Plasmodium Adenylosuccinate synthetase (Malaria Adss) DMOTXP1 MT DTT DMOTXP1 MA Inhibitor DMOTXP1 RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMOTXP1 RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMARWG5 DI DMARWG5 DMARWG5 DN HYDRAZINECARBOXAMIDE DMARWG5 MI TT3WG5C DMARWG5 MN Monoamine oxidase type A (MAO-A) DMARWG5 MT DTT DMARWG5 MA Inhibitor DMARWG5 RN Fluorinated phenylcyclopropylamines. 2. Effects of aromatic ring substitution and of absolute configuration on inhibition of microbial tyramine oxi... J Med Chem. 2004 Nov 18;47(24):5860-71. DMARWG5 RU https://pubmed.ncbi.nlm.nih.gov/15537343 DMARWG5 DI DMARWG5 DMARWG5 DN HYDRAZINECARBOXAMIDE DMARWG5 MI TTGP7BY DMARWG5 MN Monoamine oxidase type B (MAO-B) DMARWG5 MT DTT DMARWG5 MA Inhibitor DMARWG5 RN Fluorinated phenylcyclopropylamines. 2. Effects of aromatic ring substitution and of absolute configuration on inhibition of microbial tyramine oxi... J Med Chem. 2004 Nov 18;47(24):5860-71. DMARWG5 RU https://pubmed.ncbi.nlm.nih.gov/15537343 DM0HQF6 DI DM0HQF6 DM0HQF6 DN Hydrohalisulfate 1 DM0HQF6 MI TTN9T81 DM0HQF6 MN Arachidonate 15-lipoxygenase (15-LOX) DM0HQF6 MT DTT DM0HQF6 MA Inhibitor DM0HQF6 RN Exploring sponge-derived terpenoids for their potency and selectivity against 12-human, 15-human, and 15-soybean lipoxygenases. J Nat Prod. 2003 Feb;66(2):230-5. DM0HQF6 RU https://pubmed.ncbi.nlm.nih.gov/12608855 DM0HQF6 DI DM0HQF6 DM0HQF6 DN Hydrohalisulfate 1 DM0HQF6 MI TT58ZYW DM0HQF6 MN Mycobacterium Isocitrate lyase (MycB icl) DM0HQF6 MT DTT DM0HQF6 MA Inhibitor DM0HQF6 RN Sesterterpene sulfates as isocitrate lyase inhibitors from tropical sponge Hippospongia sp. Bioorg Med Chem Lett. 2007 May 1;17(9):2483-6. DM0HQF6 RU https://pubmed.ncbi.nlm.nih.gov/17317180 DMWH92F DI DMWH92F DMWH92F DN Hydrolyzed Cephalothin DMWH92F MI TTHI19T DMWH92F MN Staphylococcus Beta-lactamase (Stap-coc blaZ) DMWH92F MT DTT DMWH92F MA Inhibitor DMWH92F RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMWH92F RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMO32HN DI DMO32HN DMO32HN DN HYDROSULFIDE DMO32HN MI TTHQPL7 DMO32HN MN Carbonic anhydrase I (CA-I) DMO32HN MT DTT DMO32HN MA Inhibitor DMO32HN RN Carbonic anhydrase inhibitors: inhibition of the membrane-bound human isozyme IV with anions. Bioorg Med Chem Lett. 2004 Dec 6;14(23):5769-73. DMO32HN RU https://pubmed.ncbi.nlm.nih.gov/15501038 DMO32HN DI DMO32HN DMO32HN DN HYDROSULFIDE DMO32HN MI TTANPDJ DMO32HN MN Carbonic anhydrase II (CA-II) DMO32HN MT DTT DMO32HN MA Inhibitor DMO32HN RN Carbonic anhydrase inhibitors. Inhibition of the newly isolated murine isozyme XIII with anions. Bioorg Med Chem Lett. 2004 Nov 1;14(21):5435-9. DMO32HN RU https://pubmed.ncbi.nlm.nih.gov/15454240 DMO32HN DI DMO32HN DMO32HN DN HYDROSULFIDE DMO32HN MI TT2LVK8 DMO32HN MN Carbonic anhydrase IX (CA-IX) DMO32HN MT DTT DMO32HN MA Inhibitor DMO32HN RN Carbonic anhydrase inhibitors: inhibition of the membrane-bound human isozyme IV with anions. Bioorg Med Chem Lett. 2004 Dec 6;14(23):5769-73. DMO32HN RU https://pubmed.ncbi.nlm.nih.gov/15501038 DMA4SIN DI DMA4SIN DMA4SIN DN HYDROXY[3-(6-METHYLPYRIDIN-2-YL)PROPYL]FORMAMIDE DMA4SIN MI TTICO5G DMA4SIN MN Staphylococcus Peptide deformylase (Stap-coc def) DMA4SIN MT DTT DMA4SIN MA Inhibitor DMA4SIN RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DMA4SIN RU https://pubmed.ncbi.nlm.nih.gov/10592235 DMQFBH6 DI DMQFBH6 DMQFBH6 DN Hydroxyacetic acid DMQFBH6 MI TTKN8W0 DMQFBH6 MN Glucose-6-phosphate dehydrogenase (G6PD) DMQFBH6 MT DTT DMQFBH6 MA Inhibitor DMQFBH6 RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMQFBH6 RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMQFBH6 DI DMQFBH6 DMQFBH6 DN Hydroxyacetic acid DMQFBH6 MI DT342ZG DMQFBH6 MN Monocarboxylate transporter 1 (SLC16A1) DMQFBH6 MT DTP DMQFBH6 MA Substrate DMQFBH6 RN Cidofovir peptide conjugates as prodrugs. Journal of Organometallic Chemistry, 2005, 690(10):2673-2678. DMQFBH6 RU https://doi.org/10.1016/j.jorganchem.2005.03.004 DM5HWZY DI DM5HWZY DM5HWZY DN Hydroxyalanine DM5HWZY MI TTBFROQ DM5HWZY MN S-adenosylmethionine decarboxylase proenzyme (AMD1) DM5HWZY MT DTT DM5HWZY MA Inhibitor DM5HWZY RN DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Nucleic Acids Res. 2011 Jan;39(Database issue):D1035-41. DM5HWZY RU https://pubmed.ncbi.nlm.nih.gov/21059682 DMUVCRQ DI DMUVCRQ DMUVCRQ DN Hydroxyaminovaline DMUVCRQ MI TTHY57M DMUVCRQ MN Matrix metalloproteinase-13 (MMP-13) DMUVCRQ MT DTT DMUVCRQ MA Inhibitor DMUVCRQ RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMUVCRQ RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMUVCRQ DI DMUVCRQ DMUVCRQ DN Hydroxyaminovaline DMUVCRQ MI TTUZ2L5 DMUVCRQ MN Matrix metalloproteinase-3 (MMP-3) DMUVCRQ MT DTT DMUVCRQ MA Inhibitor DMUVCRQ RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMUVCRQ RU https://pubmed.ncbi.nlm.nih.gov/17139284 DM9H5EN DI DM9H5EN DM9H5EN DN Hydroxybenzo(a)pyrene DM9H5EN MI DENZ6B1 DM9H5EN MN UDP-glucuronosyltransferase 2B15 (UGT2B15) DM9H5EN MT DME DM9H5EN MA Metabolism DM9H5EN RN Importance of UDP-glucuronosyltransferase 1A10 (UGT1A10) in the detoxification of polycyclic aromatic hydrocarbons: decreased glucuronidative activity of the UGT1A10139Lys isoform. Drug Metab Dispos. 2006 Jun;34(6):943-9. DM9H5EN RU https://www.ncbi.nlm.nih.gov/pubmed/?term=16510539 DM9H5EN DI DM9H5EN DM9H5EN DN Hydroxybenzo(a)pyrene DM9H5EN MI DEAZDL8 DM9H5EN MN UDP-glucuronosyltransferase 2B17 (UGT2B17) DM9H5EN MT DME DM9H5EN MA Metabolism DM9H5EN RN Importance of UDP-glucuronosyltransferase 1A10 (UGT1A10) in the detoxification of polycyclic aromatic hydrocarbons: decreased glucuronidative activity of the UGT1A10139Lys isoform. Drug Metab Dispos. 2006 Jun;34(6):943-9. DM9H5EN RU https://www.ncbi.nlm.nih.gov/pubmed/?term=16510539 DMFSKYE DI DMFSKYE DMFSKYE DN Hydroxybenzo[a]pyrene DMFSKYE MI DENZ6B1 DMFSKYE MN UDP-glucuronosyltransferase 2B15 (UGT2B15) DMFSKYE MT DME DMFSKYE MA Metabolism DMFSKYE RN Importance of UDP-glucuronosyltransferase 1A10 (UGT1A10) in the detoxification of polycyclic aromatic hydrocarbons: decreased glucuronidative activity of the UGT1A10139Lys isoform. Drug Metab Dispos. 2006 Jun;34(6):943-9. DMFSKYE RU https://www.ncbi.nlm.nih.gov/pubmed/?term=16510539 DMFSKYE DI DMFSKYE DMFSKYE DN Hydroxybenzo[a]pyrene DMFSKYE MI DEAZDL8 DMFSKYE MN UDP-glucuronosyltransferase 2B17 (UGT2B17) DMFSKYE MT DME DMFSKYE MA Metabolism DMFSKYE RN Importance of UDP-glucuronosyltransferase 1A10 (UGT1A10) in the detoxification of polycyclic aromatic hydrocarbons: decreased glucuronidative activity of the UGT1A10139Lys isoform. Drug Metab Dispos. 2006 Jun;34(6):943-9. DMFSKYE RU https://www.ncbi.nlm.nih.gov/pubmed/?term=16510539 DM0PCWZ DI DM0PCWZ DM0PCWZ DN Hydroxybutyryl-CoA DM0PCWZ MI DEMK5U6 DM0PCWZ MN Acyl-CoA thioesterase 13 (ACOT13) DM0PCWZ MT DME DM0PCWZ MA Metabolism DM0PCWZ RN The mechanisms of human hotdog-fold thioesterase 2 (hTHEM2) substrate recognition and catalysis illuminated by a structure and function based analysis. Biochemistry. 2009 Feb 17;48(6):1293-304. DM0PCWZ RU https://www.ncbi.nlm.nih.gov/pubmed/?term=19170545 DM6IEKW DI DM6IEKW DM6IEKW DN Hydroxy-cholesten-one DM6IEKW MI DEVON3M DM6IEKW MN Aldo-keto reductase 1D1 (AKR1D1) DM6IEKW MT DME DM6IEKW MA Metabolism DM6IEKW RN The effect of disease associated point mutations on 5-beta-reductase (AKR1D1) enzyme function. Chem Biol Interact. 2011 May 30;191(1-3):250-4. DM6IEKW RU https://www.ncbi.nlm.nih.gov/pubmed/?term=21185810 DMY0A9E DI DMY0A9E DMY0A9E DN Hydroxycitric acid DMY0A9E MI TTCGSZ4 DMY0A9E MN Pancreatic alpha-amylase (AMY2A) DMY0A9E MT DTT DMY0A9E MA Inhibitor DMY0A9E RN Chemistry, physiological properties, and microbial production of hydroxycitric acid. Appl Microbiol Biotechnol. 2007 Jul;75(5):977-82. DMY0A9E RU https://pubmed.ncbi.nlm.nih.gov/17476502 DMFHCV9 DI DMFHCV9 DMFHCV9 DN hydroxycitronellal DMFHCV9 MI TTXDKTO DMFHCV9 MN Long transient receptor potential channel 8 (TRPM8) DMFHCV9 MT DTT DMFHCV9 MA Activator DMFHCV9 RN Characterization of the mouse cold-menthol receptor TRPM8 and vanilloid receptor type-1 VR1 using a fluorometric imaging plate reader (FLIPR) assay. Br J Pharmacol. 2004 Feb;141(4):737-45. DMFHCV9 RU https://pubmed.ncbi.nlm.nih.gov/14757700 DM5DOEC DI DM5DOEC DM5DOEC DN Hydroxyclemastine DM5DOEC MI TTTIBOJ DM5DOEC MN Histamine H1 receptor (H1R) DM5DOEC MT DTT DM5DOEC MA Antagonist DM5DOEC RN Histamine upregulates keratinocyte MMP-9 production via the histamine H1 receptor. J Invest Dermatol. 2008 Dec;128(12):2783-91. DM5DOEC RU https://pubmed.ncbi.nlm.nih.gov/18548114 DMPS2B1 DI DMPS2B1 DMPS2B1 DN Hydroxydimethylarsine Oxide DMPS2B1 MI TTFBNVI DMPS2B1 MN Aldose reductase (AKR1B1) DMPS2B1 MT DTT DMPS2B1 MA Inhibitor DMPS2B1 RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMPS2B1 RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMPS2B1 DI DMPS2B1 DMPS2B1 DN Hydroxydimethylarsine Oxide DMPS2B1 MI TTCM4B3 DMPS2B1 MN Nitric-oxide synthase endothelial (NOS3) DMPS2B1 MT DTT DMPS2B1 MA Inhibitor DMPS2B1 RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMPS2B1 RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMJXQME DI DMJXQME DMJXQME DN Hydroxyestradiol DMJXQME MI DESD26P DMJXQME MN UDP-glucuronosyltransferase 1A6 (UGT1A6) DMJXQME MT DME DMJXQME MA Metabolism DMJXQME RN Structural and functional studies of UDP-glucuronosyltransferases. Drug Metab Rev. 1999 Nov;31(4):817-99. DMJXQME RU https://www.ncbi.nlm.nih.gov/pubmed/?term=10575553 DMBO7ZD DI DMBO7ZD DMBO7ZD DN Hydroxyestrone DMBO7ZD MI DESD26P DMBO7ZD MN UDP-glucuronosyltransferase 1A6 (UGT1A6) DMBO7ZD MT DME DMBO7ZD MA Metabolism DMBO7ZD RN Structural and functional studies of UDP-glucuronosyltransferases. Drug Metab Rev. 1999 Nov;31(4):817-99. DMBO7ZD RU https://www.ncbi.nlm.nih.gov/pubmed/?term=10575553 DMPGAR2 DI DMPGAR2 DMPGAR2 DN Hydroxymethylpyrene DMPGAR2 MI DEM1HNL DMPGAR2 MN Alcohol dehydrogenase class-I gamma (ADH1C) DMPGAR2 MT DME DMPGAR2 MA Metabolism DMPGAR2 RN Oxidation of alcohols and reduction of aldehydes derived from methyl- and dimethylpyrenes by cDNA-expressed human alcohol dehydrogenases. Toxicology. 2008 Mar 12;245(1-2):65-75. DMPGAR2 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=18242813 DMPGAR2 DI DMPGAR2 DMPGAR2 DN Hydroxymethylpyrene DMPGAR2 MI DEOCWU3 DMPGAR2 MN Alcohol dehydrogenase class-II (ADH4) DMPGAR2 MT DME DMPGAR2 MA Metabolism DMPGAR2 RN Oxidation of alcohols and reduction of aldehydes derived from methyl- and dimethylpyrenes by cDNA-expressed human alcohol dehydrogenases. Toxicology. 2008 Mar 12;245(1-2):65-75. DMPGAR2 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=18242813 DMZN3GP DI DMZN3GP DMZN3GP DN Hydroxytryptophol DMZN3GP MI DESD26P DMZN3GP MN UDP-glucuronosyltransferase 1A6 (UGT1A6) DMZN3GP MT DME DMZN3GP MA Metabolism DMZN3GP RN Evaluation of 5-hydroxytryptophol and other endogenous serotonin (5-hydroxytryptamine) analogs as substrates for UDP-glucuronosyltransferase 1A6. Drug Metab Dispos. 2004 Aug;32(8):862-9. DMZN3GP RU https://www.ncbi.nlm.nih.gov/pubmed/?term=15258112 DM7XISZ DI DM7XISZ DM7XISZ DN HYG-440 DM7XISZ MI TTS64P2 DM7XISZ MN Androgen receptor (AR) DM7XISZ MT DTT DM7XISZ MA Antagonist DM7XISZ RN Clinical pipeline report, company report or official report of Hygeia Therapeutics. DM7XISZ RU http://www.hygeiatherapeutics.com/HYG-440.html DMEZ92A DI DMEZ92A DMEZ92A DN Hygromycin B DMEZ92A MI TT38DW5 DMEZ92A MN Bacterial 16S ribosomal RNA (Bact 16S rRNA) DMEZ92A MT DTT DMEZ92A MA Inhibitor DMEZ92A RN RNA as a target for small molecules. Curr Opin Chem Biol. 2000 Dec;4(6):678-86. DMEZ92A RU https://pubmed.ncbi.nlm.nih.gov/11102874 DMEZ92A DI DMEZ92A DMEZ92A DN Hygromycin B DMEZ92A MI TTPEFM3 DMEZ92A MN Bacterial Ribosomal ATPase RbbA (Bact rbbA) DMEZ92A MT DTT DMEZ92A MA Inhibitor DMEZ92A RN A ribosomal ATPase is a target for hygromycin B inhibition on Escherichia coli ribosomes. Antimicrob Agents Chemother. 2001 Oct;45(10):2813-9. DMEZ92A RU https://pubmed.ncbi.nlm.nih.gov/11557474 DMETS37 DI DMETS37 DMETS37 DN HYNIC Analogue DMETS37 MI TTN53ZF DMETS37 MN Leukotriene B4 receptor 1 (LTB4R) DMETS37 MT DTT DMETS37 MA Inhibitor DMETS37 RN Synthesis of leukotriene B4 antagonists labeled with In-111 or Tc-99m to image infectious and inflammatory foci. J Med Chem. 2005 Oct 6;48(20):6442-53. DMETS37 RU https://pubmed.ncbi.nlm.nih.gov/16190770 DMSIWD0 DI DMSIWD0 DMSIWD0 DN Hyodeoxycholic acid DMSIWD0 MI DESD26P DMSIWD0 MN UDP-glucuronosyltransferase 1A6 (UGT1A6) DMSIWD0 MT DME DMSIWD0 MA Metabolism DMSIWD0 RN Structural and functional studies of UDP-glucuronosyltransferases. Drug Metab Rev. 1999 Nov;31(4):817-99. DMSIWD0 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=10575553 DMSIWD0 DI DMSIWD0 DMSIWD0 DN Hyodeoxycholic acid DMSIWD0 MI DEWBT6H DMSIWD0 MN UDP-glucuronosyltransferase 2A3 (UGT2A3) DMSIWD0 MT DME DMSIWD0 MA Metabolism DMSIWD0 RN Novel polymorphic human UDP-glucuronosyltransferase 2A3: cloning, functional characterization of enzyme variants, comparative tissue expression, and gene induction. Mol Pharmacol. 2008 Sep;74(3):744-54. DMSIWD0 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=18523138 DM0U8IV DI DM0U8IV DM0U8IV DN hyp 9 DM0U8IV MI TTRBT3W DM0U8IV MN Short transient receptor potential channel 6 (TRPC6) DM0U8IV MT DTT DM0U8IV MA Activator DM0U8IV RN Simple 2,4-diacylphloroglucinols as classic transient receptor potential-6 activators--identification of a novel pharmacophore. Mol Pharmacol. 2010 Mar;77(3):368-77. DM0U8IV RU https://pubmed.ncbi.nlm.nih.gov/20008516 DMW9HTL DI DMW9HTL DMW9HTL DN HYP-10 DMW9HTL MI TTZPWGN DMW9HTL MN Voltage-gated calcium channel alpha Cav3.2 (CACNA1H) DMW9HTL MT DTT DMW9HTL MA Blocker DMW9HTL RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 536). DMW9HTL RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=536 DM2L3PE DI DM2L3PE DM2L3PE DN Hyperforin DM2L3PE MI TT2J34L DM2L3PE MN Arachidonate 5-lipoxygenase (5-LOX) DM2L3PE MT DTT DM2L3PE MA Inhibitor DM2L3PE RN Hyperforin is a dual inhibitor of cyclooxygenase-1 and 5-lipoxygenase. Biochem Pharmacol. 2002 Dec 15;64(12):1767-75. DM2L3PE RU https://pubmed.ncbi.nlm.nih.gov/12445866 DM2L3PE DI DM2L3PE DM2L3PE DN Hyperforin DM2L3PE MI TT7LCTF DM2L3PE MN Pregnane X receptor (NR1I2) DM2L3PE MT DTT DM2L3PE MA Binder DM2L3PE RN Pregnane X receptor (PXR) regulates P-glycoprotein at the blood-brain barrier: functional similarities between pig and human PXR. J Pharmacol Exp Ther. 2009 Apr;329(1):141-9. DM2L3PE RU https://pubmed.ncbi.nlm.nih.gov/19147857 DM2L3PE DI DM2L3PE DM2L3PE DN Hyperforin DM2L3PE MI TT8NGED DM2L3PE MN Prostaglandin G/H synthase 1 (COX-1) DM2L3PE MT DTT DM2L3PE MA Inhibitor DM2L3PE RN Hyperforin is a dual inhibitor of cyclooxygenase-1 and 5-lipoxygenase. Biochem Pharmacol. 2002 Dec 15;64(12):1767-75. DM2L3PE RU https://pubmed.ncbi.nlm.nih.gov/12445866 DMJKIUX DI DMJKIUX DMJKIUX DN hypoglaucin A DMJKIUX MI TT1UCIJ DMJKIUX MN C-X-C chemokine receptor type 3 (CXCR3) DMJKIUX MT DTT DMJKIUX MA Antagonist DMJKIUX RN Discovery of structurally diverse natural product antagonists of chemokine receptor CXCR3. Mol Divers. 2005;9(1-3):123-9. DMJKIUX RU https://pubmed.ncbi.nlm.nih.gov/15789559 DMLSABI DI DMLSABI DMLSABI DN Hypoxanthine DMLSABI MI DEJGDUW DMLSABI MN Cytochrome P450 1A2 (CYP1A2) DMLSABI MT DME DMLSABI MA Metabolism DMLSABI RN Rapid determination of five probe drugs and their metabolites in human plasma and urine by liquid chromatography/tandem mass spectrometry: application to cytochrome P450 phenotyping studies. Rapid Commun Mass Spectrom. 2004;18(23):2921-33. DMLSABI RU https://www.ncbi.nlm.nih.gov/pubmed/?term=15529418 DMLSABI DI DMLSABI DMLSABI DN Hypoxanthine DMLSABI MI TTMCF1Y DMLSABI MN Purine nucleoside phosphorylase (PNP) DMLSABI MT DTT DMLSABI MA Inhibitor DMLSABI RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMLSABI RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMWLJ5S DI DMWLJ5S DMWLJ5S DN Hyrtiosulawesine DMWLJ5S MI TT9V5JH DMWLJ5S MN Phospholipase A2 (PLA2G1B) DMWLJ5S MT DTT DMWLJ5S MA Inhibitor DMWLJ5S RN Hyrtiazepine, an azepino-indole-type alkaloid from the Red Sea marine sponge Hyrtios erectus. J Nat Prod. 2006 Dec;69(12):1676-9. DMWLJ5S RU https://pubmed.ncbi.nlm.nih.gov/17190441 DMLU6VM DI DMLU6VM DMLU6VM DN HZ-166 DMLU6VM MI TTEX6LM DMLU6VM MN GABA(A) receptor gamma-3 (GABRG3) DMLU6VM MT DTT DMLU6VM MA Modulator DMLU6VM RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 415). DMLU6VM RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=415 DM7QE51 DI DM7QE51 DM7QE51 DN I-309 DM7QE51 MI TTE836A DM7QE51 MN C-C chemokine receptor type 8 (CCR8) DM7QE51 MT DTT DM7QE51 MA Binder DM7QE51 RN The chemokine receptor CCR8 is preferentially expressed in Th2 but not Th1 cells. J Immunol. 1998 Jul 15;161(2):547-51. DM7QE51 RU https://pubmed.ncbi.nlm.nih.gov/9670926 DM1TQ7N DI DM1TQ7N DM1TQ7N DN I-5 DM1TQ7N MI TTRSMW9 DM1TQ7N MN Glycogen synthase kinase-3 beta (GSK-3B) DM1TQ7N MT DTT DM1TQ7N MA Inhibitor DM1TQ7N RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DM1TQ7N RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMFSAK3 DI DMFSAK3 DMFSAK3 DN IAA-94 DMFSAK3 MI TT0FC1V DMFSAK3 MN Volume regulated chloride channel (VRAC) DMFSAK3 MT DTT DMFSAK3 MA Blocker (channel blocker) DMFSAK3 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 710). DMFSAK3 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=710 DMIJ2GV DI DMIJ2GV DMIJ2GV DN I-ABA DMIJ2GV MI TTJFY5U DMIJ2GV MN Adenosine A3 receptor (ADORA3) DMIJ2GV MT DTT DMIJ2GV MA Agonist DMIJ2GV RN Molecular cloning and characterization of the human A3 adenosine receptor. Proc Natl Acad Sci U S A. 1993 Nov 1;90(21):10365-9. DMIJ2GV RU https://pubmed.ncbi.nlm.nih.gov/8234299 DM5X0JS DI DM5X0JS DM5X0JS DN I-ABOPX DM5X0JS MI TTNE7KG DM5X0JS MN Adenosine A2b receptor (ADORA2B) DM5X0JS MT DTT DM5X0JS MA Antagonist DM5X0JS RN Characterization of human A(2B) adenosine receptors: radioligand binding, western blotting, and coupling to G(q) in human embryonic kidney 293 cells and HMC-1 mast cells. Mol Pharmacol. 1999 Oct;56(4):705-13. DM5X0JS RU https://pubmed.ncbi.nlm.nih.gov/10496952 DM5X0JS DI DM5X0JS DM5X0JS DN I-ABOPX DM5X0JS MI TTJFY5U DM5X0JS MN Adenosine A3 receptor (ADORA3) DM5X0JS MT DTT DM5X0JS MA Antagonist DM5X0JS RN Molecular cloning and characterization of the human A3 adenosine receptor. Proc Natl Acad Sci U S A. 1993 Nov 1;90(21):10365-9. DM5X0JS RU https://pubmed.ncbi.nlm.nih.gov/8234299 DMOQIDG DI DMOQIDG DMOQIDG DN IAI-100 DMOQIDG MI TTOMWSY DMOQIDG MN Mammalian disintegrin-metalloprotease (ADAM10) DMOQIDG MT DTT DMOQIDG MA Inhibitor DMOQIDG RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 8679). DMOQIDG RU http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=8679 DM8U4HE DI DM8U4HE DM8U4HE DN IATX-FVIII DM8U4HE MI TT1290U DM8U4HE MN Coagulation factor VIII (F8) DM8U4HE MT DTT DM8U4HE MA Inhibitor DM8U4HE RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2607). DM8U4HE RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2607 DM8J24A DI DM8J24A DM8J24A DN IBC 293 DM8J24A MI TT8WFXV DM8J24A MN Hydroxycarboxylic acid receptor 3 (HCAR3) DM8J24A MT DTT DM8J24A MA Agonist DM8J24A RN 1-Alkyl-benzotriazole-5-carboxylic acids are highly selective agonists of the human orphan G-protein-coupled receptor GPR109b. J Med Chem. 2006 Feb 23;49(4):1227-30. DM8J24A RU https://pubmed.ncbi.nlm.nih.gov/16480258 DMRIG3O DI DMRIG3O DMRIG3O DN iberiotoxin DMRIG3O MI TTGJFK1 DMRIG3O MN Calcium-activated potassium channel KCa4.1 (KCNT1) DMRIG3O MT DTT DMRIG3O MA Inhibitor DMRIG3O RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 385). DMRIG3O RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=385 DMRIG3O DI DMRIG3O DMRIG3O DN iberiotoxin DMRIG3O MI TTLU5FO DMRIG3O MN Calcium-activated potassium channel KCa4.2 (KCNT2) DMRIG3O MT DTT DMRIG3O MA Inhibitor DMRIG3O RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 386). DMRIG3O RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=386 DMRIG3O DI DMRIG3O DMRIG3O DN iberiotoxin DMRIG3O MI TTI9XK6 DMRIG3O MN Calcium-activated potassium channel KCa5.1 (KCNU1) DMRIG3O MT DTT DMRIG3O MA Inhibitor DMRIG3O RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 387). DMRIG3O RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=387 DMRIG3O DI DMRIG3O DMRIG3O DN iberiotoxin DMRIG3O MI TT1AQ50 DMRIG3O MN Charybdotoxin receptor beta-4 (BKbeta4) DMRIG3O MT DTT DMRIG3O MA Inhibitor DMRIG3O RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 380). DMRIG3O RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=380 DMYRUH2 DI DMYRUH2 DMYRUH2 DN I-BET151 DMYRUH2 MI TTDP48B DMYRUH2 MN Bromodomain-containing protein 2 (BRD2) DMYRUH2 MT DTT DMYRUH2 MA Inhibitor DMYRUH2 RN Inhibition of BET recruitment to chromatin as an effective treatment for MLL-fusion leukaemia. Nature. 2011 Oct 2;478(7370):529-33. DMYRUH2 RU https://pubmed.ncbi.nlm.nih.gov/21964340 DMYRUH2 DI DMYRUH2 DMYRUH2 DN I-BET151 DMYRUH2 MI TTHE657 DMYRUH2 MN Bromodomain-containing protein 3 (BRD3) DMYRUH2 MT DTT DMYRUH2 MA Inhibitor DMYRUH2 RN Inhibition of BET recruitment to chromatin as an effective treatment for MLL-fusion leukaemia. Nature. 2011 Oct 2;478(7370):529-33. DMYRUH2 RU https://pubmed.ncbi.nlm.nih.gov/21964340 DMYRUH2 DI DMYRUH2 DMYRUH2 DN I-BET151 DMYRUH2 MI TTRA6BO DMYRUH2 MN Bromodomain-containing protein 4 (BRD4) DMYRUH2 MT DTT DMYRUH2 MA Inhibitor DMYRUH2 RN Inhibition of BET recruitment to chromatin as an effective treatment for MLL-fusion leukaemia. Nature. 2011 Oct 2;478(7370):529-33. DMYRUH2 RU https://pubmed.ncbi.nlm.nih.gov/21964340 DM3HJX7 DI DM3HJX7 DM3HJX7 DN Ibogaine DM3HJX7 MI TTMT0HG DM3HJX7 MN Neuronal acetylcholine receptor alpha-2/alpha-3 (CHRNA2/A3) DM3HJX7 MT DTT DM3HJX7 MA Antagonist DM3HJX7 RN Antagonism of alpha 3 beta 4 nicotinic receptors as a strategy to reduce opioid and stimulant self-administration. Eur J Pharmacol. 2002 Mar 1;438(1-2):99-105. DM3HJX7 RU https://pubmed.ncbi.nlm.nih.gov/11906717 DMJAPML DI DMJAPML DMJAPML DN I-BOP DMJAPML MI TTPNGDE DMJAPML MN Prostaglandin E2 receptor EP3 (PTGER3) DMJAPML MT DTT DMJAPML MA Agonist DMJAPML RN Ligand binding specificities of the eight types and subtypes of the mouse prostanoid receptors expressed in Chinese hamster ovary cells. Br J Pharmacol. 1997 Sep;122(2):217-24. DMJAPML RU https://pubmed.ncbi.nlm.nih.gov/9313928 DMJAPML DI DMJAPML DMJAPML DN I-BOP DMJAPML MI TTT2ZAR DMJAPML MN Prostaglandin F2-alpha receptor (PTGFR) DMJAPML MT DTT DMJAPML MA Agonist DMJAPML RN Ligand binding specificities of the eight types and subtypes of the mouse prostanoid receptors expressed in Chinese hamster ovary cells. Br J Pharmacol. 1997 Sep;122(2):217-24. DMJAPML RU https://pubmed.ncbi.nlm.nih.gov/9313928 DMJAPML DI DMJAPML DMJAPML DN I-BOP DMJAPML MI TT2O84V DMJAPML MN Thromboxane A2 receptor (TBXA2R) DMJAPML MT DTT DMJAPML MA Agonist DMJAPML RN Ligand binding specificities of the eight types and subtypes of the mouse prostanoid receptors expressed in Chinese hamster ovary cells. Br J Pharmacol. 1997 Sep;122(2):217-24. DMJAPML RU https://pubmed.ncbi.nlm.nih.gov/9313928 DM8RZE0 DI DM8RZE0 DM8RZE0 DN ibotenate DM8RZE0 MI TTVBPDM DM8RZE0 MN Metabotropic glutamate receptor 1 (mGluR1) DM8RZE0 MT DTT DM8RZE0 MA Agonist DM8RZE0 RN Characterization of [(3)H]Quisqualate binding to recombinant rat metabotropic glutamate 1a and 5a receptors and to rat and human brain sections. J Neurochem. 2000 Dec;75(6):2590-601. DM8RZE0 RU https://pubmed.ncbi.nlm.nih.gov/11080213 DM8RZE0 DI DM8RZE0 DM8RZE0 DN ibotenate DM8RZE0 MI TTHS256 DM8RZE0 MN Metabotropic glutamate receptor 5 (mGluR5) DM8RZE0 MT DTT DM8RZE0 MA Agonist DM8RZE0 RN Characterization of [(3)H]Quisqualate binding to recombinant rat metabotropic glutamate 1a and 5a receptors and to rat and human brain sections. J Neurochem. 2000 Dec;75(6):2590-601. DM8RZE0 RU https://pubmed.ncbi.nlm.nih.gov/11080213 DM9C8FP DI DM9C8FP DM9C8FP DN I-BRD9 DM9C8FP MI TTR7L5Y DM9C8FP MN Bromodomain-containing protein 9 (BRD9) DM9C8FP MT DTT DM9C8FP MA Inhibitor DM9C8FP RN Discovery of I-BRD9, a Selective Cell Active Chemical Probe for Bromodomain Containing Protein 9 Inhibition. J Med Chem. 2016 Feb 25;59(4):1425-39. DM9C8FP RU https://pubmed.ncbi.nlm.nih.gov/25856009 DMUSRJ8 DI DMUSRJ8 DMUSRJ8 DN IBZM DMUSRJ8 MI TTZFYLI DMUSRJ8 MN Dopamine D1 receptor (D1R) DMUSRJ8 MT DTT DMUSRJ8 MA Inhibitor DMUSRJ8 RN In vitro affinities of various halogenated benzamide derivatives as potential radioligands for non-invasive quantification of D(2)-like dopamine re... Bioorg Med Chem. 2007 Nov 1;15(21):6819-29. DMUSRJ8 RU https://pubmed.ncbi.nlm.nih.gov/17765546 DMUSRJ8 DI DMUSRJ8 DMUSRJ8 DN IBZM DMUSRJ8 MI TTEX248 DMUSRJ8 MN Dopamine D2 receptor (D2R) DMUSRJ8 MT DTT DMUSRJ8 MA Inhibitor DMUSRJ8 RN Fluorinated and iodinated dopamine agents: D2 imaging agents for PET and SPECT. J Med Chem. 1993 Jan 22;36(2):221-8. DMUSRJ8 RU https://pubmed.ncbi.nlm.nih.gov/8093734 DMRF5LU DI DMRF5LU DMRF5LU DN IC-041 DMRF5LU MI TT3ZS42 DMRF5LU MN Phosphodiesterase 1B (PDE1B) DMRF5LU MT DTT DMRF5LU MA Inhibitor DMRF5LU RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1295). DMRF5LU RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1295 DMWRVGE DI DMWRVGE DMWRVGE DN IC86621 DMWRVGE MI TTK3PY9 DMWRVGE MN DNA-dependent protein kinase catalytic (PRKDC) DMWRVGE MT DTT DMWRVGE MA Inhibitor DMWRVGE RN Modulation of DNA repair by pharmacological inhibitors of the PIKK protein kinase family. Bioorg Med Chem Lett. 2012 Sep 1;22(17):5352-9. DMWRVGE RU https://pubmed.ncbi.nlm.nih.gov/22835870 DMM50ED DI DMM50ED DMM50ED DN IC87114 DMM50ED MI TTGBPJE DMM50ED MN PI3-kinase delta (PIK3CD) DMM50ED MT DTT DMM50ED MA Inhibitor DMM50ED RN Selective role of PI3K delta in neutrophil inflammatory responses. Biochem Biophys Res Commun. 2003 Sep 5;308(4):764-9. DMM50ED RU https://pubmed.ncbi.nlm.nih.gov/12927784 DM8L6WB DI DM8L6WB DM8L6WB DN IC980033 DM8L6WB MI TTGBPJE DM8L6WB MN PI3-kinase delta (PIK3CD) DM8L6WB MT DTT DM8L6WB MA Inhibitor DM8L6WB RN Selective role of PI3K delta in neutrophil inflammatory responses. Biochem Biophys Res Commun. 2003 Sep 5;308(4):764-9. DM8L6WB RU https://pubmed.ncbi.nlm.nih.gov/12927784 DMS9H2P DI DMS9H2P DMS9H2P DN ICA-105574 DMS9H2P MI TT9XKUC DMS9H2P MN Voltage-gated potassium channel Kv10.1 (KCNH1) DMS9H2P MT DTT DMS9H2P MA Inhibitor (gating inhibitor) DMS9H2P RN ICA-105574 interacts with a common binding site to elicit opposite effects on inactivation gating of EAG and ERG potassium channels. Mol Pharmacol. 2013 Apr;83(4):805-13. DMS9H2P RU https://pubmed.ncbi.nlm.nih.gov/23319419 DMS9H2P DI DMS9H2P DMS9H2P DN ICA-105574 DMS9H2P MI TTQ6VDM DMS9H2P MN Voltage-gated potassium channel Kv11.1 (KCNH2) DMS9H2P MT DTT DMS9H2P MA Activator DMS9H2P RN Pharmacological removal of human ether- -go-go-related gene potassium channel inactivation by 3-nitro-N-(4-phenoxyphenyl) benzamide (ICA-105574). Mol Pharmacol. 2010 Jan;77(1):58-68. DMS9H2P RU https://pubmed.ncbi.nlm.nih.gov/19805508 DMO0N3Q DI DMO0N3Q DMO0N3Q DN ICA-27243 DMO0N3Q MI TTPXI3S DMO0N3Q MN Voltage-gated potassium channel Kv7.2 (KCNQ2) DMO0N3Q MT DTT DMO0N3Q MA Activator DMO0N3Q RN The KCNQ2/3 selective channel opener ICA-27243 binds to a novel voltage-sensor domain site. Neurosci Lett. 2009 Nov 13;465(2):138-42. DMO0N3Q RU https://pubmed.ncbi.nlm.nih.gov/19733209 DM3DB8X DI DM3DB8X DM3DB8X DN Icariside II DM3DB8X MI TTJ0IQB DM3DB8X MN Phosphodiesterase 5A (PDE5A) DM3DB8X MT DTT DM3DB8X MA Inhibitor DM3DB8X RN Potent inhibition of human phosphodiesterase-5 by icariin derivatives. J Nat Prod. 2008 Sep;71(9):1513-7. DM3DB8X RU https://pubmed.ncbi.nlm.nih.gov/18778098 DMQX3W6 DI DMQX3W6 DMQX3W6 DN I-CBP112 DMQX3W6 MI TTFRCTK DMQX3W6 MN CREB-binding protein (CREBBP) DMQX3W6 MT DTT DMQX3W6 MA Inhibitor DMQX3W6 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2734). DMQX3W6 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2734 DMQX3W6 DI DMQX3W6 DMQX3W6 DN I-CBP112 DMQX3W6 MI TTH4VJL DMQX3W6 MN Histone acetyltransferase KAT6B (KAT6B) DMQX3W6 MT DTT DMQX3W6 MA Inhibitor DMQX3W6 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2735). DMQX3W6 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2735 DMN6UET DI DMN6UET DMN6UET DN ICI 154129 DMN6UET MI TT27RFC DMN6UET MN Opioid receptor delta (OPRD1) DMN6UET MT DTT DMN6UET MA Antagonist DMN6UET RN In vivo evidence for the selectivity of ICI 154129 for the delta-opioid receptor. Neuropharmacology. 1985 Feb;24(2):107-10. DMN6UET RU https://pubmed.ncbi.nlm.nih.gov/2986029 DMLPZ3N DI DMLPZ3N DMLPZ3N DN ICI 200,355 DMLPZ3N MI TTPLTSQ DMLPZ3N MN Neutrophil elastase (NE) DMLPZ3N MT DTT DMLPZ3N MA Inhibitor DMLPZ3N RN Role of neutrophil elastase in hypersecretion in asthma. Eur Respir J. 1999 Jan;13(1):190-6. DMLPZ3N RU https://pubmed.ncbi.nlm.nih.gov/10836347 DM0PQ37 DI DM0PQ37 DM0PQ37 DN ICI 200,880 DM0PQ37 MI TTPLTSQ DM0PQ37 MN Neutrophil elastase (NE) DM0PQ37 MT DTT DM0PQ37 MA Inhibitor DM0PQ37 RN Neutrophil elastase inhibitors as treatment for COPD. Expert Opin Investig Drugs. 2002 Jul;11(7):965-80. DM0PQ37 RU https://pubmed.ncbi.nlm.nih.gov/12084007 DM1D6CQ DI DM1D6CQ DM1D6CQ DN ICI-174864 DM1D6CQ MI TT27RFC DM1D6CQ MN Opioid receptor delta (OPRD1) DM1D6CQ MT DTT DM1D6CQ MA Inhibitor DM1D6CQ RN Highly potent and selective phenylmorphan-based inverse agonists of the opioid delta receptor. J Med Chem. 2006 Sep 7;49(18):5597-609. DM1D6CQ RU https://pubmed.ncbi.nlm.nih.gov/16942033 DMW4L3K DI DMW4L3K DMW4L3K DN ICI-198583 DMW4L3K MI TT5FOMZ DMW4L3K MN Thymidylate synthase (TYMS) DMW4L3K MT DTT DMW4L3K MA Modulator DMW4L3K RN The biochemical pharmacology of the thymidylate synthase inhibitor, 2-desamino-2-methyl-N10-propargyl-5,8-dideazafolic acid (ICI 198583). Biochem Pharmacol. 1991 Oct 24;42(10):1885-95. DMW4L3K RU https://www.ncbi.nlm.nih.gov/pubmed/1741766 DMEWZ80 DI DMEWZ80 DMEWZ80 DN ICI-199441 DMEWZ80 MI TTVG215 DMEWZ80 MN Debrisoquine 4-hydroxylase (CYP2D6) DMEWZ80 MT DTT DMEWZ80 MA Inhibitor DMEWZ80 RN Arylacetamide kappa opioid receptor agonists with reduced cytochrome P450 2D6 inhibitory activity. Bioorg Med Chem Lett. 2005 May 16;15(10):2647-52. DMEWZ80 RU https://pubmed.ncbi.nlm.nih.gov/15863335 DMEWZ80 DI DMEWZ80 DMEWZ80 DN ICI-199441 DMEWZ80 MI TT27RFC DMEWZ80 MN Opioid receptor delta (OPRD1) DMEWZ80 MT DTT DMEWZ80 MA Inhibitor DMEWZ80 RN Arylacetamide kappa opioid receptor agonists with reduced cytochrome P450 2D6 inhibitory activity. Bioorg Med Chem Lett. 2005 May 16;15(10):2647-52. DMEWZ80 RU https://pubmed.ncbi.nlm.nih.gov/15863335 DMEWZ80 DI DMEWZ80 DMEWZ80 DN ICI-199441 DMEWZ80 MI TTQW87Y DMEWZ80 MN Opioid receptor kappa (OPRK1) DMEWZ80 MT DTT DMEWZ80 MA Inhibitor DMEWZ80 RN Arylacetamide-derived fluorescent probes: synthesis, biological evaluation, and direct fluorescent labeling of kappa opioid receptors in mouse micr... J Med Chem. 1996 Apr 12;39(8):1729-35. DMEWZ80 RU https://pubmed.ncbi.nlm.nih.gov/8648612 DMEWZ80 DI DMEWZ80 DMEWZ80 DN ICI-199441 DMEWZ80 MI TTKWM86 DMEWZ80 MN Opioid receptor mu (MOP) DMEWZ80 MT DTT DMEWZ80 MA Inhibitor DMEWZ80 RN Isothiocyanate-substituted kappa-selective opioid receptor ligands derived from N-methyl-N-[(1S)-1-phenyl-2-(1-pyrrolidinyl)ethyl] phenylacetamide. J Med Chem. 1994 Sep 2;37(18):2856-64. DMEWZ80 RU https://pubmed.ncbi.nlm.nih.gov/8071934 DMEWZ80 DI DMEWZ80 DMEWZ80 DN ICI-199441 DMEWZ80 MI TTW5UDX DMEWZ80 MN Urotensin II receptor (UTS2R) DMEWZ80 MT DTT DMEWZ80 MA Inhibitor DMEWZ80 RN Potent and selective small-molecule human urotensin-II antagonists with improved pharmacokinetic profiles. Bioorg Med Chem Lett. 2008 Jul 1;18(13):3716-9. DMEWZ80 RU https://pubmed.ncbi.nlm.nih.gov/18524591 DMNA8RS DI DMNA8RS DMNA8RS DN ICI-204448 DMNA8RS MI TTQW87Y DMNA8RS MN Opioid receptor kappa (OPRK1) DMNA8RS MT DTT DMNA8RS MA Modulator DMNA8RS RN ICI 204448: a kappa-opioid agonist with limited access to the CNS. DMNA8RS RU https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1854424 DMYRILU DI DMYRILU DMYRILU DN ICI-211965 DMYRILU MI TT2J34L DMYRILU MN Arachidonate 5-lipoxygenase (5-LOX) DMYRILU MT DTT DMYRILU MA Modulator DMYRILU RN DOI: 10.1517/13543776.2.11.1817 DMYRILU RU http://www.tandfonline.com/doi/abs/10.1517/13543776.2.11.1817?journalCode=ietp19 DMYVOL9 DI DMYVOL9 DMYVOL9 DN icilin DMYVOL9 MI TTXDKTO DMYVOL9 MN Long transient receptor potential channel 8 (TRPM8) DMYVOL9 MT DTT DMYVOL9 MA Activator DMYVOL9 RN Evolution of thermal response properties in a cold-activated TRP channel. PLoS One. 2009 May 29;4(5):e5741. DMYVOL9 RU https://pubmed.ncbi.nlm.nih.gov/19492038 DMYVOL9 DI DMYVOL9 DMYVOL9 DN icilin DMYVOL9 MI TTELV3W DMYVOL9 MN Transformation-sensitive protein p120 (TRPA1) DMYVOL9 MT DTT DMYVOL9 MA Activator DMYVOL9 RN ANKTM1, a TRP-like channel expressed in nociceptive neurons, is activated by cold temperatures. Cell. 2003 Mar 21;112(6):819-29. DMYVOL9 RU https://pubmed.ncbi.nlm.nih.gov/12654248 DMF1CM7 DI DMF1CM7 DMF1CM7 DN Icosapentum DMF1CM7 MI DE073H6 DMF1CM7 MN Prostaglandin G/H synthase 1 (COX-1) DMF1CM7 MT DME DMF1CM7 MA Metabolism DMF1CM7 RN Divergent cyclooxygenase responses to fatty acid structure and peroxide level in fish and mammalian prostaglandin H synthases. FASEB J. 2006 Jun;20(8):1097-108. DMF1CM7 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=16770009 DMF1CM7 DI DMF1CM7 DMF1CM7 DN Icosapentum DMF1CM7 MI DE492CE DMF1CM7 MN Prostaglandin G/H synthase 2 (COX-2) DMF1CM7 MT DME DMF1CM7 MA Metabolism DMF1CM7 RN Divergent cyclooxygenase responses to fatty acid structure and peroxide level in fish and mammalian prostaglandin H synthases. FASEB J. 2006 Jun;20(8):1097-108. DMF1CM7 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=16770009 DMH4KGX DI DMH4KGX DMH4KGX DN ICR 62 DMH4KGX MI TTGKNB4 DMH4KGX MN Epidermal growth factor receptor (EGFR) DMH4KGX MT DTT DMH4KGX RN Monoclonal antibodies to target epidermal growth factor receptor-positive tumors: a new paradigm for cancer therapy. Cancer. 2002 Mar 1;94(5):1593-611. DMH4KGX RU https://pubmed.ncbi.nlm.nih.gov/11920518 DM9DXRL DI DM9DXRL DM9DXRL DN ICRF-154 DM9DXRL MI TT0IHXV DM9DXRL MN DNA topoisomerase II (TOP2) DM9DXRL MT DTT DM9DXRL MA Inhibitor DM9DXRL RN The catalytic DNA topoisomerase II inhibitor ICRF-193 and all-trans retinoic acid cooperatively induce granulocytic differentiation of acute promyelocytic leukemia cells: candidate drugs for chemo-differentiation therapy against acute promyelocytic leukemia. Exp Hematol. 2002 Nov;30(11):1273-82. DM9DXRL RU https://pubmed.ncbi.nlm.nih.gov/12423680 DMPH8E9 DI DMPH8E9 DMPH8E9 DN ICT-037 DMPH8E9 MI TTY6DTE DMPH8E9 MN Carcinoembryonic antigen CEA (CD66e) DMPH8E9 MT DTT DMPH8E9 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2836). DMPH8E9 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2836 DM3P7W5 DI DM3P7W5 DM3P7W5 DN IDD552 DM3P7W5 MI TTFBNVI DM3P7W5 MN Aldose reductase (AKR1B1) DM3P7W5 MT DTT DM3P7W5 MA Inhibitor DM3P7W5 RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DM3P7W5 RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMDHLG3 DI DMDHLG3 DMDHLG3 DN IDD594 DMDHLG3 MI TTFBNVI DMDHLG3 MN Aldose reductase (AKR1B1) DMDHLG3 MT DTT DMDHLG3 MA Inhibitor DMDHLG3 RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DMDHLG3 RU https://pubmed.ncbi.nlm.nih.gov/10592235 DMBFX5H DI DMBFX5H DMBFX5H DN IDDBCP226234 DMBFX5H MI TT69J2Z DMBFX5H MN Serine/threonine-protein kinase pim-2 (PIM2) DMBFX5H MT DTT DMBFX5H MA Inhibitor DMBFX5H RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2159). DMBFX5H RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2159 DMRQSN2 DI DMRQSN2 DMRQSN2 DN IDN-1965 DMRQSN2 MI TTZY5KP DMRQSN2 MN Caspase (CASP) DMRQSN2 MT DTT DMRQSN2 MA Inhibitor DMRQSN2 RN Inhibition of cardiac myocyte apoptosis improves cardiac function and abolishes mortality in the peripartum cardiomyopathy of Galpha(q) transgenic ... Circulation. 2003 Dec 16;108(24):3036-41. DMRQSN2 RU https://pubmed.ncbi.nlm.nih.gov/14638549 DMNS9KW DI DMNS9KW DMNS9KW DN IDN-5174 DMNS9KW MI TTGTQHC DMNS9KW MN DNA topoisomerase I (TOP1) DMNS9KW MT DTT DMNS9KW MA Inhibitor DMNS9KW RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2636). DMNS9KW RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2636 DM1OMSW DI DM1OMSW DM1OMSW DN IDN-5390 DM1OMSW MI TTYFKSZ DM1OMSW MN Tubulin beta (TUBB) DM1OMSW MT DTT DM1OMSW MA Modulator DM1OMSW RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2640). DM1OMSW RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2640 DM6TEWZ DI DM6TEWZ DM6TEWZ DN IDN-6384 DM6TEWZ MI TTGTQHC DM6TEWZ MN DNA topoisomerase I (TOP1) DM6TEWZ MT DTT DM6TEWZ MA Inhibitor DM6TEWZ RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2636). DM6TEWZ RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2636 DMOU234 DI DMOU234 DMOU234 DN IGEL1.2 DMOU234 MI TTYJQTF DMOU234 MN Immunoglobulin E (IgE) DMOU234 MT DTT DMOU234 RN Therapeutic applications of aptamers. Expert Opin Investig Drugs. 2008 Jan;17(1):43-60. DMOU234 RU https://pubmed.ncbi.nlm.nih.gov/18095918 DMFMY1L DI DMFMY1L DMFMY1L DN IGERNELLIN DMFMY1L MI TTN9T81 DMFMY1L MN Arachidonate 15-lipoxygenase (15-LOX) DMFMY1L MT DTT DMFMY1L MA Inhibitor DMFMY1L RN Exploring sponge-derived terpenoids for their potency and selectivity against 12-human, 15-human, and 15-soybean lipoxygenases. J Nat Prod. 2003 Feb;66(2):230-5. DMFMY1L RU https://pubmed.ncbi.nlm.nih.gov/12608855 DMLYIBO DI DMLYIBO DMLYIBO DN IIK7 DMLYIBO MI TT0WAIE DMLYIBO MN Melatonin receptor type 1A (MTNR1A) DMLYIBO MT DTT DMLYIBO MA Agonist DMLYIBO RN Mapping the melatonin receptor. 6. Melatonin agonists and antagonists derived from 6H-isoindolo[2,1-a]indoles, 5,6-dihydroindolo[2,1-a]isoquinolines, and 6,7-dihydro-5H-benzo[c]azepino[2,1-a]indoles.J Med Chem. 2000 Mar 23;43(6):1050-61. DMLYIBO RU https://pubmed.ncbi.nlm.nih.gov/10737738 DMJA4UE DI DMJA4UE DMJA4UE DN IK-862 DMJA4UE MI TTQICM2 DMJA4UE MN ADAM metallopeptidase 33 (ADAM33) DMJA4UE MT DTT DMJA4UE MA Inhibitor DMJA4UE RN Specific targeting of metzincin family members with small-molecule inhibitors: progress toward a multifarious challenge. Bioorg Med Chem. 2008 Oct 1;16(19):8781-94. DMJA4UE RU https://pubmed.ncbi.nlm.nih.gov/18790648 DMJA4UE DI DMJA4UE DMJA4UE DN IK-862 DMJA4UE MI TTHY57M DMJA4UE MN Matrix metalloproteinase-13 (MMP-13) DMJA4UE MT DTT DMJA4UE MA Inhibitor DMJA4UE RN Discovery of gamma-lactam hydroxamic acids as selective inhibitors of tumor necrosis factor alpha converting enzyme: design, synthesis, and structu... J Med Chem. 2002 Nov 7;45(23):4954-7. DMJA4UE RU https://pubmed.ncbi.nlm.nih.gov/12408705 DMJA4UE DI DMJA4UE DMJA4UE DN IK-862 DMJA4UE MI TTJ4QE7 DMJA4UE MN Matrix metalloproteinase-14 (MMP-14) DMJA4UE MT DTT DMJA4UE MA Inhibitor DMJA4UE RN Discovery of gamma-lactam hydroxamic acids as selective inhibitors of tumor necrosis factor alpha converting enzyme: design, synthesis, and structu... J Med Chem. 2002 Nov 7;45(23):4954-7. DMJA4UE RU https://pubmed.ncbi.nlm.nih.gov/12408705 DMJA4UE DI DMJA4UE DMJA4UE DN IK-862 DMJA4UE MI TTLM12X DMJA4UE MN Matrix metalloproteinase-2 (MMP-2) DMJA4UE MT DTT DMJA4UE MA Inhibitor DMJA4UE RN Discovery of gamma-lactam hydroxamic acids as selective inhibitors of tumor necrosis factor alpha converting enzyme: design, synthesis, and structu... J Med Chem. 2002 Nov 7;45(23):4954-7. DMJA4UE RU https://pubmed.ncbi.nlm.nih.gov/12408705 DMJA4UE DI DMJA4UE DMJA4UE DN IK-862 DMJA4UE MI TTYRF5E DMJA4UE MN Matrix metalloproteinase-21 (MMP-21) DMJA4UE MT DTT DMJA4UE MA Inhibitor DMJA4UE RN Discovery of gamma-lactam hydroxamic acids as selective inhibitors of tumor necrosis factor alpha converting enzyme: design, synthesis, and structu... J Med Chem. 2002 Nov 7;45(23):4954-7. DMJA4UE RU https://pubmed.ncbi.nlm.nih.gov/12408705 DMJA4UE DI DMJA4UE DMJA4UE DN IK-862 DMJA4UE MI TTUZ2L5 DMJA4UE MN Matrix metalloproteinase-3 (MMP-3) DMJA4UE MT DTT DMJA4UE MA Inhibitor DMJA4UE RN Discovery of gamma-lactam hydroxamic acids as selective inhibitors of tumor necrosis factor alpha converting enzyme: design, synthesis, and structu... J Med Chem. 2002 Nov 7;45(23):4954-7. DMJA4UE RU https://pubmed.ncbi.nlm.nih.gov/12408705 DMJA4UE DI DMJA4UE DMJA4UE DN IK-862 DMJA4UE MI TTMTWOS DMJA4UE MN Matrix metalloproteinase-7 (MMP-7) DMJA4UE MT DTT DMJA4UE MA Inhibitor DMJA4UE RN Discovery of gamma-lactam hydroxamic acids as selective inhibitors of tumor necrosis factor alpha converting enzyme: design, synthesis, and structu... J Med Chem. 2002 Nov 7;45(23):4954-7. DMJA4UE RU https://pubmed.ncbi.nlm.nih.gov/12408705 DMJA4UE DI DMJA4UE DMJA4UE DN IK-862 DMJA4UE MI TTGA1IV DMJA4UE MN Matrix metalloproteinase-8 (MMP-8) DMJA4UE MT DTT DMJA4UE MA Inhibitor DMJA4UE RN Discovery of gamma-lactam hydroxamic acids as selective inhibitors of tumor necrosis factor alpha converting enzyme: design, synthesis, and structu... J Med Chem. 2002 Nov 7;45(23):4954-7. DMJA4UE RU https://pubmed.ncbi.nlm.nih.gov/12408705 DMJA4UE DI DMJA4UE DMJA4UE DN IK-862 DMJA4UE MI TT6X50U DMJA4UE MN Matrix metalloproteinase-9 (MMP-9) DMJA4UE MT DTT DMJA4UE MA Inhibitor DMJA4UE RN Discovery of gamma-lactam hydroxamic acids as selective inhibitors of tumor necrosis factor alpha converting enzyme: design, synthesis, and structu... J Med Chem. 2002 Nov 7;45(23):4954-7. DMJA4UE RU https://pubmed.ncbi.nlm.nih.gov/12408705 DMJA4UE DI DMJA4UE DMJA4UE DN IK-862 DMJA4UE MI TT6AZXG DMJA4UE MN TNF alpha converting enzyme (ADAM17) DMJA4UE MT DTT DMJA4UE MA Inhibitor DMJA4UE RN Specific targeting of metzincin family members with small-molecule inhibitors: progress toward a multifarious challenge. Bioorg Med Chem. 2008 Oct 1;16(19):8781-94. DMJA4UE RU https://pubmed.ncbi.nlm.nih.gov/18790648 DMJA4UE DI DMJA4UE DMJA4UE DN IK-862 DMJA4UE MI TTF8CQI DMJA4UE MN Tumor necrosis factor (TNF) DMJA4UE MT DTT DMJA4UE MA Inhibitor DMJA4UE RN Discovery of gamma-lactam hydroxamic acids as selective inhibitors of tumor necrosis factor alpha converting enzyme: design, synthesis, and structu... J Med Chem. 2002 Nov 7;45(23):4954-7. DMJA4UE RU https://pubmed.ncbi.nlm.nih.gov/12408705 DM2X3EV DI DM2X3EV DM2X3EV DN IkappaB-alphaM DM2X3EV MI TTSXVID DM2X3EV MN Nuclear factor NF-kappa-B (NFKB) DM2X3EV MT DTT DM2X3EV MA Inhibitor DM2X3EV RN An IkappaB-alpha mutant inhibits cytokine gene expression and proliferation in human vascular smooth muscle cells. J Surg Res. 2002 Feb;102(2):198-206. DM2X3EV RU https://pubmed.ncbi.nlm.nih.gov/11796019 DM94AIL DI DM94AIL DM94AIL DN IKH-25 DM94AIL MI TT5ZKDI DM94AIL MN Histone deacetylase 6 (HDAC6) DM94AIL MT DTT DM94AIL MA Inhibitor DM94AIL RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2618). DM94AIL RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2618 DM8GQ9X DI DM8GQ9X DM8GQ9X DN IKI-1 DM8GQ9X MI TTWLVKG DM8GQ9X MN Inhibitor of nuclear factor kappa-B kinase alpha (IKKA) DM8GQ9X MT DTT DM8GQ9X MA Inhibitor DM8GQ9X RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1989). DM8GQ9X RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1989 DMLY5IF DI DMLY5IF DMLY5IF DN IKs124 DMLY5IF MI TT846HF DMLY5IF MN Voltage-gated potassium channel Kv7.1 (KCNQ1) DMLY5IF MT DTT DMLY5IF MA Blocker (channel blocker) DMLY5IF RN Heteromeric KCNE2/KCNQ1 potassium channels in the luminal membrane of gastric parietal cells. J Physiol. 2004 Dec 1;561(Pt 2):547-57. DMLY5IF RU https://pubmed.ncbi.nlm.nih.gov/15579540 DMU6AMP DI DMU6AMP DMU6AMP DN IL-2 antibody (anti-tumor) DMU6AMP MI TTF89GD DMU6AMP MN Interleukin-2 (IL2) DMU6AMP MT DTT DMU6AMP MA Modulator DMU6AMP RN An anti-IL-2 antibody increases serum half-life and improves anti-tumor efficacy of human recombinant interleukin-2. Immunopharmacology. 1994 Nov-Dec;28(3):223-32. DMU6AMP RU https://www.ncbi.nlm.nih.gov/pubmed/7852053 DM10Z5W DI DM10Z5W DM10Z5W DN Il-8((3-73))K11R DM10Z5W MI TTMWT8Z DM10Z5W MN C-X-C chemokine receptor type 1 (CXCR1) DM10Z5W MT DTT DM10Z5W MA Agonist DM10Z5W RN Il-8((3-73))K11R is a high affinity agonist of the neutrophil CXCR1 and CXCR2. Biochem Biophys Res Commun. 2001 Aug 24;286(3):595-600. DM10Z5W RU https://pubmed.ncbi.nlm.nih.gov/11511101 DM10Z5W DI DM10Z5W DM10Z5W DN Il-8((3-73))K11R DM10Z5W MI TT30C9G DM10Z5W MN C-X-C chemokine receptor type 2 (CXCR2) DM10Z5W MT DTT DM10Z5W MA Agonist DM10Z5W RN Il-8((3-73))K11R is a high affinity agonist of the neutrophil CXCR1 and CXCR2. Biochem Biophys Res Commun. 2001 Aug 24;286(3):595-600. DM10Z5W RU https://pubmed.ncbi.nlm.nih.gov/11511101 DMPNQ27 DI DMPNQ27 DMPNQ27 DN Il-94 DMPNQ27 MI TTFN95D DMPNQ27 MN PAK-1 protein kinase (PAK1) DMPNQ27 MT DTT DMPNQ27 MA Inhibitor DMPNQ27 RN PAK1: A Therapeutic Target for Cancer Treatment. ACS Med Chem Lett. 2013 Mar 19;4(5):431-2. DMPNQ27 RU https://pubmed.ncbi.nlm.nih.gov/24900689 DMPNQ27 DI DMPNQ27 DMPNQ27 DN Il-94 DMPNQ27 MI TT279WO DMPNQ27 MN PAK-2 protein kinase (PAK2) DMPNQ27 MT DTT DMPNQ27 MA Inhibitor DMPNQ27 RN PAK1: A Therapeutic Target for Cancer Treatment. ACS Med Chem Lett. 2013 Mar 19;4(5):431-2. DMPNQ27 RU https://pubmed.ncbi.nlm.nih.gov/24900689 DMPIV1G DI DMPIV1G DMPIV1G DN Ilatreotide DMPIV1G MI TTOMNR9 DMPIV1G MN Somatostatin receptor (SSTR) DMPIV1G MT DTT DMPIV1G MA Modulator DMPIV1G RN Inhibitory effect of intraduodenal administration of somatostatin analogue SDZ CO 611 on rat pancreatic exocrine secretion. Pancreas. 1993 Jul;8(4):471-5. DMPIV1G RU https://www.ncbi.nlm.nih.gov/pubmed/8361968 DMZW0YO DI DMZW0YO DMZW0YO DN IM-023911 DMZW0YO MI TTUTJGQ DMZW0YO MN Vascular endothelial growth factor receptor 2 (KDR) DMZW0YO MT DTT DMZW0YO MA Inhibitor DMZW0YO RN Arylphthalazines: identification of a new phthalazine chemotype as inhibitors of VEGFR kinase. Bioorg Med Chem Lett. 2005 Nov 1;15(21):4696-8. DMZW0YO RU https://pubmed.ncbi.nlm.nih.gov/16143524 DMTFV65 DI DMTFV65 DMTFV65 DN IM-094261 DMTFV65 MI TTUTJGQ DMTFV65 MN Vascular endothelial growth factor receptor 2 (KDR) DMTFV65 MT DTT DMTFV65 MA Inhibitor DMTFV65 RN Arylphthalazines: identification of a new phthalazine chemotype as inhibitors of VEGFR kinase. Bioorg Med Chem Lett. 2005 Nov 1;15(21):4696-8. DMTFV65 RU https://pubmed.ncbi.nlm.nih.gov/16143524 DMTFV65 DI DMTFV65 DMTFV65 DN IM-094261 DMTFV65 MI TT1VAUK DMTFV65 MN VEGFR1 messenger RNA (VEGFR1 mRNA) DMTFV65 MT DTT DMTFV65 MA Inhibitor DMTFV65 RN Arylphthalazines: identification of a new phthalazine chemotype as inhibitors of VEGFR kinase. Bioorg Med Chem Lett. 2005 Nov 1;15(21):4696-8. DMTFV65 RU https://pubmed.ncbi.nlm.nih.gov/16143524 DMO18YN DI DMO18YN DMO18YN DN IM-094882 DMO18YN MI TTUTJGQ DMO18YN MN Vascular endothelial growth factor receptor 2 (KDR) DMO18YN MT DTT DMO18YN MA Inhibitor DMO18YN RN Arylphthalazines. Part 2: 1-(Isoquinolin-5-yl)-4-arylamino phthalazines as potent inhibitors of VEGF receptors I and II. Bioorg Med Chem Lett. 2006 Mar 15;16(6):1579-81. DMO18YN RU https://pubmed.ncbi.nlm.nih.gov/16386418 DMO18YN DI DMO18YN DMO18YN DN IM-094882 DMO18YN MI TT1VAUK DMO18YN MN VEGFR1 messenger RNA (VEGFR1 mRNA) DMO18YN MT DTT DMO18YN MA Inhibitor DMO18YN RN Arylphthalazines. Part 2: 1-(Isoquinolin-5-yl)-4-arylamino phthalazines as potent inhibitors of VEGF receptors I and II. Bioorg Med Chem Lett. 2006 Mar 15;16(6):1579-81. DMO18YN RU https://pubmed.ncbi.nlm.nih.gov/16386418 DM58DGY DI DM58DGY DM58DGY DN IM-12 DM58DGY MI TTRSMW9 DM58DGY MN Glycogen synthase kinase-3 beta (GSK-3B) DM58DGY MT DTT DM58DGY MA Inhibitor DM58DGY RN Novel indolylmaleimide acts as GSK-3beta inhibitor in human neural progenitor cells. Bioorg Med Chem. 2010 Sep 15;18(18):6785-95. DM58DGY RU https://pubmed.ncbi.nlm.nih.gov/20708937 DMUQO86 DI DMUQO86 DMUQO86 DN IM-491 DMUQO86 MI TT6AZXG DMUQO86 MN TNF alpha converting enzyme (ADAM17) DMUQO86 MT DTT DMUQO86 MA Inhibitor DMUQO86 RN Discovery of beta-benzamido hydroxamic acids as potent, selective, and orally bioavailable TACE inhibitors. Bioorg Med Chem Lett. 2008 Jan 1;18(1):241-6. DMUQO86 RU https://pubmed.ncbi.nlm.nih.gov/18032037 DMPKWUO DI DMPKWUO DMPKWUO DN imbutamine DMPKWUO MI TT9JNIC DMPKWUO MN Histamine H3 receptor (H3R) DMPKWUO MT DTT DMPKWUO MA Agonist DMPKWUO RN Synthesis and structure-activity relationships of conformationally constrained histamine H(3) receptor agonists. J Med Chem. 2003 Dec 4;46(25):5445-57. DMPKWUO RU https://pubmed.ncbi.nlm.nih.gov/14640553 DMMJ6NS DI DMMJ6NS DMMJ6NS DN Imetit DMMJ6NS MI TT9JNIC DMMJ6NS MN Histamine H3 receptor (H3R) DMMJ6NS MT DTT DMMJ6NS MA Agonist DMMJ6NS RN The histamine H3 receptor: from gene cloning to H3 receptor drugs. Nat Rev Drug Discov. 2005 Feb;4(2):107-20. DMMJ6NS RU https://pubmed.ncbi.nlm.nih.gov/15665857 DMMJ6NS DI DMMJ6NS DMMJ6NS DN Imetit DMMJ6NS MI TTXJ178 DMMJ6NS MN Histamine H4 receptor (H4R) DMMJ6NS MT DTT DMMJ6NS MA Agonist DMMJ6NS RN Histamine excites neonatal rat sympathetic preganglionic neurons in vitro via activation of H1 receptors. J Neurophysiol. 2006 Apr;95(4):2492-500. DMMJ6NS RU https://pubmed.ncbi.nlm.nih.gov/16354729 DMTGRAF DI DMTGRAF DMTGRAF DN Imidazolidin-2-ylidene-o-tolyl-amine DMTGRAF MI TTNGILX DMTGRAF MN Adrenergic receptor alpha-1A (ADRA1A) DMTGRAF MT DTT DMTGRAF MA Inhibitor DMTGRAF RN Analogs of UK 14,304: Structural features responsible for alpha2 adrenoceptor activity, Bioorg. Med. Chem. Lett. 5(15):1745-1750 (1995). DMTGRAF RU http://www.sciencedirect.com/science/article/pii/0960894X95002955 DMTGRAF DI DMTGRAF DMTGRAF DN Imidazolidin-2-ylidene-o-tolyl-amine DMTGRAF MI TTBRKXS DMTGRAF MN Adrenergic receptor alpha-1B (ADRA1B) DMTGRAF MT DTT DMTGRAF MA Inhibitor DMTGRAF RN Analogs of UK 14,304: Structural features responsible for alpha2 adrenoceptor activity, Bioorg. Med. Chem. Lett. 5(15):1745-1750 (1995). DMTGRAF RU http://www.sciencedirect.com/science/article/pii/0960894X95002955 DMTGRAF DI DMTGRAF DMTGRAF DN Imidazolidin-2-ylidene-o-tolyl-amine DMTGRAF MI TT34BHT DMTGRAF MN Adrenergic receptor alpha-1D (ADRA1D) DMTGRAF MT DTT DMTGRAF MA Inhibitor DMTGRAF RN Analogs of UK 14,304: Structural features responsible for alpha2 adrenoceptor activity, Bioorg. Med. Chem. Lett. 5(15):1745-1750 (1995). DMTGRAF RU http://www.sciencedirect.com/science/article/pii/0960894X95002955 DMZ5ISH DI DMZ5ISH DMZ5ISH DN Imidazolidin-2-ylidene-quinoxalin-6-yl-amine DMZ5ISH MI TTNGILX DMZ5ISH MN Adrenergic receptor alpha-1A (ADRA1A) DMZ5ISH MT DTT DMZ5ISH MA Inhibitor DMZ5ISH RN Analogs of UK 14,304: Structural features responsible for alpha2 adrenoceptor activity, Bioorg. Med. Chem. Lett. 5(15):1745-1750 (1995). DMZ5ISH RU http://www.sciencedirect.com/science/article/pii/0960894X95002955 DMZ5ISH DI DMZ5ISH DMZ5ISH DN Imidazolidin-2-ylidene-quinoxalin-6-yl-amine DMZ5ISH MI TTBRKXS DMZ5ISH MN Adrenergic receptor alpha-1B (ADRA1B) DMZ5ISH MT DTT DMZ5ISH MA Inhibitor DMZ5ISH RN Analogs of UK 14,304: Structural features responsible for alpha2 adrenoceptor activity, Bioorg. Med. Chem. Lett. 5(15):1745-1750 (1995). DMZ5ISH RU http://www.sciencedirect.com/science/article/pii/0960894X95002955 DMZ5ISH DI DMZ5ISH DMZ5ISH DN Imidazolidin-2-ylidene-quinoxalin-6-yl-amine DMZ5ISH MI TT34BHT DMZ5ISH MN Adrenergic receptor alpha-1D (ADRA1D) DMZ5ISH MT DTT DMZ5ISH MA Inhibitor DMZ5ISH RN Analogs of UK 14,304: Structural features responsible for alpha2 adrenoceptor activity, Bioorg. Med. Chem. Lett. 5(15):1745-1750 (1995). DMZ5ISH RU http://www.sciencedirect.com/science/article/pii/0960894X95002955 DMS4D96 DI DMS4D96 DMS4D96 DN imiloxan DMS4D96 MI TTWM4TY DMS4D96 MN Adrenergic receptor alpha-2B (ADRA2B) DMS4D96 MT DTT DMS4D96 MA Antagonist DMS4D96 RN Assessment of imiloxan as a selective alpha 2B-adrenoceptor antagonist. Br J Pharmacol. 1990 Mar;99(3):560-4. DMS4D96 RU https://pubmed.ncbi.nlm.nih.gov/1970500 DMSINGH DI DMSINGH DMSINGH DN Imino sugars DMSINGH MI TTXWASR DMSINGH MN Intestinal maltase-glucoamylase (MGAM) DMSINGH MT DTT DMSINGH MA Modulator DMSINGH RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2627). DMSINGH RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2627 DMZKABS DI DMZKABS DMZKABS DN Imipramine oxide DMZKABS MI DEJGDUW DMZKABS MN Cytochrome P450 1A2 (CYP1A2) DMZKABS MT DME DMZKABS MA Metabolism DMZKABS RN Major pathway of imipramine metabolism is catalyzed by cytochromes P-450 1A2 and P-450 3A4 in human liver. Mol Pharmacol. 1993 May;43(5):827-32. DMZKABS RU https://www.ncbi.nlm.nih.gov/pubmed/?term=8502233 DMZKABS DI DMZKABS DMZKABS DN Imipramine oxide DMZKABS MI DE4LYSA DMZKABS MN Cytochrome P450 3A4 (CYP3A4) DMZKABS MT DME DMZKABS MA Metabolism DMZKABS RN Major pathway of imipramine metabolism is catalyzed by cytochromes P-450 1A2 and P-450 3A4 in human liver. Mol Pharmacol. 1993 May;43(5):827-32. DMZKABS RU https://www.ncbi.nlm.nih.gov/pubmed/?term=8502233 DMDM3Y1 DI DMDM3Y1 DMDM3Y1 DN Immepip DMDM3Y1 MI TT9JNIC DMDM3Y1 MN Histamine H3 receptor (H3R) DMDM3Y1 MT DTT DMDM3Y1 MA Agonist DMDM3Y1 RN The histamine H3 receptor: from gene cloning to H3 receptor drugs. Nat Rev Drug Discov. 2005 Feb;4(2):107-20. DMDM3Y1 RU https://pubmed.ncbi.nlm.nih.gov/15665857 DM7YQ26 DI DM7YQ26 DM7YQ26 DN Immethridine DM7YQ26 MI TT9JNIC DM7YQ26 MN Histamine H3 receptor (H3R) DM7YQ26 MT DTT DM7YQ26 MA Agonist DM7YQ26 RN The histamine H3 receptor: from gene cloning to H3 receptor drugs. Nat Rev Drug Discov. 2005 Feb;4(2):107-20. DM7YQ26 RU https://pubmed.ncbi.nlm.nih.gov/15665857 DMX2NKO DI DMX2NKO DMX2NKO DN Immucillin-G DMX2NKO MI TTMCF1Y DMX2NKO MN Purine nucleoside phosphorylase (PNP) DMX2NKO MT DTT DMX2NKO MA Inhibitor DMX2NKO RN Exploring structure-activity relationships of transition state analogues of human purine nucleoside phosphorylase. J Med Chem. 2003 Jul 17;46(15):3412-23. DMX2NKO RU https://pubmed.ncbi.nlm.nih.gov/12852771 DM1TQXO DI DM1TQXO DM1TQXO DN IMP-731 DM1TQXO MI TTNVXAW DM1TQXO MN Lymphocyte activation gene 3 protein (LAG3) DM1TQXO MT DTT DM1TQXO MA Modulator DM1TQXO RN IMP321 (sLAG-3), an immunopotentiator for T cell responses against a HBsAg antigen in healthy adults: a single blind randomised controlled phase I study. J Immune Based Ther Vaccines. 2007 Mar 29;5:5. DM1TQXO RU https://pubmed.ncbi.nlm.nih.gov/17394654 DMPJXZN DI DMPJXZN DMPJXZN DN impentamine DMPJXZN MI TT9JNIC DMPJXZN MN Histamine H3 receptor (H3R) DMPJXZN MT DTT DMPJXZN MA Agonist DMPJXZN RN Synthesis and structure-activity relationships of conformationally constrained histamine H(3) receptor agonists. J Med Chem. 2003 Dec 4;46(25):5445-57. DMPJXZN RU https://pubmed.ncbi.nlm.nih.gov/14640553 DMVLW6R DI DMVLW6R DMVLW6R DN IMPERATORIN DMVLW6R MI TTO9X1H DMVLW6R MN 5-HT 7 receptor (HTR7) DMVLW6R MT DTT DMVLW6R MA Inhibitor DMVLW6R RN Serotonergic activity-guided phytochemical investigation of the roots of Angelica sinensis. J Nat Prod. 2006 Apr;69(4):536-41. DMVLW6R RU https://pubmed.ncbi.nlm.nih.gov/16643021 DMQ4ICU DI DMQ4ICU DMQ4ICU DN improgan DMQ4ICU MI TTXJ178 DMQ4ICU MN Histamine H4 receptor (H4R) DMQ4ICU MT DTT DMQ4ICU MA Agonist DMQ4ICU RN Cloning, expression, and pharmacological characterization of a novel human histamine receptor. Mol Pharmacol. 2001 Mar;59(3):434-41. DMQ4ICU RU https://pubmed.ncbi.nlm.nih.gov/11179436 DMTDRPM DI DMTDRPM DMTDRPM DN impromidine DMTDRPM MI TTTIBOJ DMTDRPM MN Histamine H1 receptor (H1R) DMTDRPM MT DTT DMTDRPM MA Antagonist DMTDRPM RN Probing ligand-specific histamine H1- and H2-receptor conformations with NG-acylated Imidazolylpropylguanidines. J Pharmacol Exp Ther. 2006 Apr;317(1):139-46. DMTDRPM RU https://pubmed.ncbi.nlm.nih.gov/16394198 DMTDRPM DI DMTDRPM DMTDRPM DN impromidine DMTDRPM MI TTQHJ1K DMTDRPM MN Histamine H2 receptor (H2R) DMTDRPM MT DTT DMTDRPM MA Agonist DMTDRPM RN Probing ligand-specific histamine H1- and H2-receptor conformations with NG-acylated Imidazolylpropylguanidines. J Pharmacol Exp Ther. 2006 Apr;317(1):139-46. DMTDRPM RU https://pubmed.ncbi.nlm.nih.gov/16394198 DMTDRPM DI DMTDRPM DMTDRPM DN impromidine DMTDRPM MI TT9JNIC DMTDRPM MN Histamine H3 receptor (H3R) DMTDRPM MT DTT DMTDRPM MA Agonist DMTDRPM RN Cloning and pharmacological characterization of a fourth histamine receptor (H(4)) expressed in bone marrow. Mol Pharmacol. 2001 Mar;59(3):420-6. DMTDRPM RU https://pubmed.ncbi.nlm.nih.gov/11179434 DMTDRPM DI DMTDRPM DMTDRPM DN impromidine DMTDRPM MI TTXJ178 DMTDRPM MN Histamine H4 receptor (H4R) DMTDRPM MT DTT DMTDRPM MA Agonist DMTDRPM RN Evaluation of histamine H1-, H2-, and H3-receptor ligands at the human histamine H4 receptor: identification of 4-methylhistamine as the first pote... J Pharmacol Exp Ther. 2005 Sep;314(3):1310-21. DMTDRPM RU https://pubmed.ncbi.nlm.nih.gov/15947036 DM3YJXF DI DM3YJXF DM3YJXF DN IN-1130 DM3YJXF MI TTQBR95 DM3YJXF MN Stress-activated protein kinase 2a (p38 alpha) DM3YJXF MT DTT DM3YJXF MA Inhibitor DM3YJXF RN Synthesis and biological evaluation of trisubstituted imidazole derivatives as inhibitors of p38alpha mitogen-activated protein kinase. Bioorg Med Chem Lett. 2008 Jul 15;18(14):4006-10. DM3YJXF RU https://pubmed.ncbi.nlm.nih.gov/18571921 DM3YJXF DI DM3YJXF DM3YJXF DN IN-1130 DM3YJXF MI TTP4520 DM3YJXF MN TGF-beta receptor type I (TGFBR1) DM3YJXF MT DTT DM3YJXF MA Inhibitor DM3YJXF RN Synthesis and biological evaluation of 4(5)-(6-methylpyridin-2-yl)imidazoles and -pyrazoles as transforming growth factor-beta type 1 receptor kina... Bioorg Med Chem. 2010 Jun 15;18(12):4459-67. DM3YJXF RU https://pubmed.ncbi.nlm.nih.gov/20472445 DMMS6D3 DI DMMS6D3 DMMS6D3 DN IN-1166 DMMS6D3 MI TT3IVG2 DMMS6D3 MN JNK2 messenger RNA (JNK2 mRNA) DMMS6D3 MT DTT DMMS6D3 MA Inhibitor DMMS6D3 RN Synthesis and biological evaluation of 4(5)-(6-alkylpyridin-2-yl)imidazoles as transforming growth factor-beta type 1 receptor kinase inhibitors. J Med Chem. 2007 Jun 28;50(13):3143-7. DMMS6D3 RU https://pubmed.ncbi.nlm.nih.gov/17552507 DMMS6D3 DI DMMS6D3 DMMS6D3 DN IN-1166 DMMS6D3 MI TTQBR95 DMMS6D3 MN Stress-activated protein kinase 2a (p38 alpha) DMMS6D3 MT DTT DMMS6D3 MA Inhibitor DMMS6D3 RN Synthesis and biological evaluation of trisubstituted imidazole derivatives as inhibitors of p38alpha mitogen-activated protein kinase. Bioorg Med Chem Lett. 2008 Jul 15;18(14):4006-10. DMMS6D3 RU https://pubmed.ncbi.nlm.nih.gov/18571921 DMMS6D3 DI DMMS6D3 DMMS6D3 DN IN-1166 DMMS6D3 MI TTP4520 DMMS6D3 MN TGF-beta receptor type I (TGFBR1) DMMS6D3 MT DTT DMMS6D3 MA Inhibitor DMMS6D3 RN Synthesis and biological evaluation of 4(5)-(6-alkylpyridin-2-yl)imidazoles as transforming growth factor-beta type 1 receptor kinase inhibitors. J Med Chem. 2007 Jun 28;50(13):3143-7. DMMS6D3 RU https://pubmed.ncbi.nlm.nih.gov/17552507 DM4JNUH DI DM4JNUH DM4JNUH DN IN1479 DM4JNUH MI TTGJCWZ DM4JNUH MN Fms-like tyrosine kinase 3 (FLT-3) DM4JNUH MT DTT DM4JNUH MA Inhibitor DM4JNUH RN Aromatic interactions with phenylalanine 691 and cysteine 828: a concept for FMS-like tyrosine kinase-3 inhibition. Application to the discovery of a new class of potential antileukemia agents. J MedChem. 2006 Jul 27;49(15):4451-4. DM4JNUH RU https://pubmed.ncbi.nlm.nih.gov/16854049 DMKFE6X DI DMKFE6X DMKFE6X DN IN1535 DMKFE6X MI TTH6V3D DMKFE6X MN Cyclin-dependent kinase 1 (CDK1) DMKFE6X MT DTT DMKFE6X MA Binder DMKFE6X RN M-phase regulation of the recruitment of mRNAs onto polysomes using the CDK1/cyclin B inhibitor aminopurvalanol. Biochem Biophys Res Commun. 2003 Jul 11;306(4):880-6. DMKFE6X RU https://pubmed.ncbi.nlm.nih.gov/12821124 DMENHMU DI DMENHMU DMENHMU DN IN-3 DMENHMU MI TT8R70G DMENHMU MN Gonadotropin-releasing hormone receptor (GNRHR) DMENHMU MT DTT DMENHMU MA Antagonist DMENHMU RN Rescue of hypogonadotropic hypogonadism-causing and manufactured GnRH receptor mutants by a specific protein-folding template: misrouted proteins as a novel disease etiology and therapeutic target. JClin Endocrinol Metab. 2002 Jul;87(7):3255-62. DMENHMU RU https://pubmed.ncbi.nlm.nih.gov/12107234 DM8E4HB DI DM8E4HB DM8E4HB DN INC-106 DM8E4HB MI TT8DBY3 DM8E4HB MN Angiotensin II receptor type-1 (AGTR1) DM8E4HB MT DTT DM8E4HB RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 34). DM8E4HB RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=34 DMZCHSD DI DMZCHSD DMZCHSD DN INCB-10820 DMZCHSD MI TTFZYTO DMZCHSD MN C-C chemokine receptor type 2 (CCR2) DMZCHSD MT DTT DMZCHSD MA Antagonist DMZCHSD RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 59). DMZCHSD RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=59 DMONMHK DI DMONMHK DMONMHK DN incensole acetate DMONMHK MI TT946IA DMONMHK MN Transient receptor potential cation channel V3 (TRPV3) DMONMHK MT DTT DMONMHK MA Activator DMONMHK RN Incensole acetate, an incense component, elicits psychoactivity by activating TRPV3 channels in the brain. FASEB J. 2008 Aug;22(8):3024-34. DMONMHK RU https://pubmed.ncbi.nlm.nih.gov/18492727 DMMLQZJ DI DMMLQZJ DMMLQZJ DN Indan-1-ol DMMLQZJ MI DEGQTXO DMMLQZJ MN Aldo-keto reductase 1C3 (AKR1C3) DMMLQZJ MT DME DMMLQZJ MA Metabolism DMMLQZJ RN Expression and characterization of four recombinant human dihydrodiol dehydrogenase isoforms: oxidation of trans-7, 8-dihydroxy-7,8-dihydrobenzo[a]pyrene to the activated o-quinone metabolite benzo[a]pyrene-7,8-dione. Biochemistry. 1998 May 12;37(19):6781-90. DMMLQZJ RU https://www.ncbi.nlm.nih.gov/pubmed/?term=9578563 DMVZMBU DI DMVZMBU DMVZMBU DN Indan-2-ylcarbamic Acid Biphenyl-3-yl Ester DMVZMBU MI TTDP1UC DMVZMBU MN Fatty acid amide hydrolase (FAAH) DMVZMBU MT DTT DMVZMBU MA Inhibitor DMVZMBU RN Synthesis and quantitative structure-activity relationship of fatty acid amide hydrolase inhibitors: modulation at the N-portion of biphenyl-3-yl a... J Med Chem. 2008 Jun 26;51(12):3487-98. DMVZMBU RU https://pubmed.ncbi.nlm.nih.gov/18507372 DM4S81A DI DM4S81A DM4S81A DN indanidine DM4S81A MI TT2NUT5 DM4S81A MN Adrenergic receptor alpha-2C (ADRA2C) DM4S81A MT DTT DM4S81A MA Agonist DM4S81A RN Selectivity of agonists for cloned alpha 1-adrenergic receptor subtypes. Mol Pharmacol. 1994 Nov;46(5):929-36. DM4S81A RU https://pubmed.ncbi.nlm.nih.gov/7969082 DMIP9DN DI DMIP9DN DMIP9DN DN Indatraline DMIP9DN MI TTVBI8W DMIP9DN MN Dopamine transporter (DAT) DMIP9DN MT DTT DMIP9DN MA Inhibitor DMIP9DN RN Effects of indatraline and buprenorphine on self-administration of speedball combinations of cocaine and heroin by rhesus monkeys. Neuropsychopharmacology. 2001 Jul;25(1):104-17. DMIP9DN RU https://pubmed.ncbi.nlm.nih.gov/11377924 DMYLVQF DI DMYLVQF DMYLVQF DN indirubin deriv. 8a DMYLVQF MI TTRSMW9 DMYLVQF MN Glycogen synthase kinase-3 beta (GSK-3B) DMYLVQF MT DTT DMYLVQF MA Inhibitor DMYLVQF RN Structural basis for the synthesis of indirubins as potent and selective inhibitors of glycogen synthase kinase-3 and cyclin-dependent kinases. J Med Chem. 2004 Feb 12;47(4):935-46. DMYLVQF RU https://pubmed.ncbi.nlm.nih.gov/14761195 DMYLVQF DI DMYLVQF DMYLVQF DN indirubin deriv. 8a DMYLVQF MI TTQWAU1 DMYLVQF MN GSK3A messenger RNA (GSK3A mRNA) DMYLVQF MT DTT DMYLVQF MA Inhibitor DMYLVQF RN Structural basis for the synthesis of indirubins as potent and selective inhibitors of glycogen synthase kinase-3 and cyclin-dependent kinases. J Med Chem. 2004 Feb 12;47(4):935-46. DMYLVQF RU https://pubmed.ncbi.nlm.nih.gov/14761195 DMFP1C5 DI DMFP1C5 DMFP1C5 DN indirubin derivative E804 DMFP1C5 MI TTXEZJ4 DMFP1C5 MN Tyrosine-protein kinase EIF2AK2 (p68) DMFP1C5 MT DTT DMFP1C5 MA Inhibitor DMFP1C5 RN Identification of new inhibitors of protein kinase R guided by statistical modeling. Bioorg Med Chem Lett. 2011 Jul 1;21(13):4108-14. DMFP1C5 RU https://pubmed.ncbi.nlm.nih.gov/21632247 DM3UR1E DI DM3UR1E DM3UR1E DN Indirubin-3-acetoxime DM3UR1E MI TT9RTBL DM3UR1E MN Aurora B messenger RNA (AURKB mRNA) DM3UR1E MT DTT DM3UR1E MA Inhibitor DM3UR1E RN An integrated computational approach to the phenomenon of potent and selective inhibition of aurora kinases B and C by a series of 7-substituted in... J Med Chem. 2007 Aug 23;50(17):4027-37. DM3UR1E RU https://pubmed.ncbi.nlm.nih.gov/17665890 DM3UR1E DI DM3UR1E DM3UR1E DN Indirubin-3-acetoxime DM3UR1E MI TTPS3C0 DM3UR1E MN Aurora kinase A (AURKA) DM3UR1E MT DTT DM3UR1E MA Inhibitor DM3UR1E RN An integrated computational approach to the phenomenon of potent and selective inhibition of aurora kinases B and C by a series of 7-substituted in... J Med Chem. 2007 Aug 23;50(17):4027-37. DM3UR1E RU https://pubmed.ncbi.nlm.nih.gov/17665890 DM3UR1E DI DM3UR1E DM3UR1E DN Indirubin-3-acetoxime DM3UR1E MI TTLYXIT DM3UR1E MN Aurora kinase C (AURKC) DM3UR1E MT DTT DM3UR1E MA Inhibitor DM3UR1E RN An integrated computational approach to the phenomenon of potent and selective inhibition of aurora kinases B and C by a series of 7-substituted in... J Med Chem. 2007 Aug 23;50(17):4027-37. DM3UR1E RU https://pubmed.ncbi.nlm.nih.gov/17665890 DMZ5ODC DI DMZ5ODC DMZ5ODC DN Indirubin-3-methoxime DMZ5ODC MI TT9RTBL DMZ5ODC MN Aurora B messenger RNA (AURKB mRNA) DMZ5ODC MT DTT DMZ5ODC MA Inhibitor DMZ5ODC RN An integrated computational approach to the phenomenon of potent and selective inhibition of aurora kinases B and C by a series of 7-substituted in... J Med Chem. 2007 Aug 23;50(17):4027-37. DMZ5ODC RU https://pubmed.ncbi.nlm.nih.gov/17665890 DMZ5ODC DI DMZ5ODC DMZ5ODC DN Indirubin-3-methoxime DMZ5ODC MI TTPS3C0 DMZ5ODC MN Aurora kinase A (AURKA) DMZ5ODC MT DTT DMZ5ODC MA Inhibitor DMZ5ODC RN An integrated computational approach to the phenomenon of potent and selective inhibition of aurora kinases B and C by a series of 7-substituted in... J Med Chem. 2007 Aug 23;50(17):4027-37. DMZ5ODC RU https://pubmed.ncbi.nlm.nih.gov/17665890 DMZ5ODC DI DMZ5ODC DMZ5ODC DN Indirubin-3-methoxime DMZ5ODC MI TTLYXIT DMZ5ODC MN Aurora kinase C (AURKC) DMZ5ODC MT DTT DMZ5ODC MA Inhibitor DMZ5ODC RN An integrated computational approach to the phenomenon of potent and selective inhibition of aurora kinases B and C by a series of 7-substituted in... J Med Chem. 2007 Aug 23;50(17):4027-37. DMZ5ODC RU https://pubmed.ncbi.nlm.nih.gov/17665890 DMLRQH0 DI DMLRQH0 DMLRQH0 DN Indirubin-3'-monoxime DMLRQH0 MI TT9RTBL DMLRQH0 MN Aurora B messenger RNA (AURKB mRNA) DMLRQH0 MT DTT DMLRQH0 MA Inhibitor DMLRQH0 RN An integrated computational approach to the phenomenon of potent and selective inhibition of aurora kinases B and C by a series of 7-substituted in... J Med Chem. 2007 Aug 23;50(17):4027-37. DMLRQH0 RU https://pubmed.ncbi.nlm.nih.gov/17665890 DMLRQH0 DI DMLRQH0 DMLRQH0 DN Indirubin-3'-monoxime DMLRQH0 MI TTPS3C0 DMLRQH0 MN Aurora kinase A (AURKA) DMLRQH0 MT DTT DMLRQH0 MA Inhibitor DMLRQH0 RN An integrated computational approach to the phenomenon of potent and selective inhibition of aurora kinases B and C by a series of 7-substituted in... J Med Chem. 2007 Aug 23;50(17):4027-37. DMLRQH0 RU https://pubmed.ncbi.nlm.nih.gov/17665890 DMLRQH0 DI DMLRQH0 DMLRQH0 DN Indirubin-3'-monoxime DMLRQH0 MI TTLYXIT DMLRQH0 MN Aurora kinase C (AURKC) DMLRQH0 MT DTT DMLRQH0 MA Inhibitor DMLRQH0 RN An integrated computational approach to the phenomenon of potent and selective inhibition of aurora kinases B and C by a series of 7-substituted in... J Med Chem. 2007 Aug 23;50(17):4027-37. DMLRQH0 RU https://pubmed.ncbi.nlm.nih.gov/17665890 DMLRQH0 DI DMLRQH0 DMLRQH0 DN Indirubin-3'-monoxime DMLRQH0 MI TTH6V3D DMLRQH0 MN Cyclin-dependent kinase 1 (CDK1) DMLRQH0 MT DTT DMLRQH0 MA Binder DMLRQH0 RN The kinase inhibitor indirubin-3'-oxime prevents germinal vesicle breakdown and reduces parthenogenetic development of pig oocytes. Theriogenology. 2006 Mar 1;65(4):744-56. DMLRQH0 RU https://pubmed.ncbi.nlm.nih.gov/16105677 DMLRQH0 DI DMLRQH0 DMLRQH0 DN Indirubin-3'-monoxime DMLRQH0 MI TT7HF4W DMLRQH0 MN Cyclin-dependent kinase 2 (CDK2) DMLRQH0 MT DTT DMLRQH0 MA Inhibitor DMLRQH0 RN Pharmacological inhibitors of cyclin-dependent kinases. Trends Pharmacol Sci. 2002 Sep;23(9):417-25. DMLRQH0 RU https://pubmed.ncbi.nlm.nih.gov/12237154 DMLRQH0 DI DMLRQH0 DMLRQH0 DN Indirubin-3'-monoxime DMLRQH0 MI TTL4Q97 DMLRQH0 MN Cyclin-dependent kinase 5 (CDK5) DMLRQH0 MT DTT DMLRQH0 MA Inhibitor DMLRQH0 RN Pharmacological inhibitors of cyclin-dependent kinases. Trends Pharmacol Sci. 2002 Sep;23(9):417-25. DMLRQH0 RU https://pubmed.ncbi.nlm.nih.gov/12237154 DM08VHZ DI DM08VHZ DM08VHZ DN Indirubin-5-sulfonate DM08VHZ MI TTH6V3D DM08VHZ MN Cyclin-dependent kinase 1 (CDK1) DM08VHZ MT DTT DM08VHZ MA Binder DM08VHZ RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DM08VHZ RU https://pubmed.ncbi.nlm.nih.gov/17139284 DM08VHZ DI DM08VHZ DM08VHZ DN Indirubin-5-sulfonate DM08VHZ MI TT7HF4W DM08VHZ MN Cyclin-dependent kinase 2 (CDK2) DM08VHZ MT DTT DM08VHZ MA Inhibitor DM08VHZ RN Pharmacological inhibitors of cyclin-dependent kinases. Trends Pharmacol Sci. 2002 Sep;23(9):417-25. DM08VHZ RU https://pubmed.ncbi.nlm.nih.gov/12237154 DM08VHZ DI DM08VHZ DM08VHZ DN Indirubin-5-sulfonate DM08VHZ MI TTL4Q97 DM08VHZ MN Cyclin-dependent kinase 5 (CDK5) DM08VHZ MT DTT DM08VHZ MA Inhibitor DM08VHZ RN Pharmacological inhibitors of cyclin-dependent kinases. Trends Pharmacol Sci. 2002 Sep;23(9):417-25. DM08VHZ RU https://pubmed.ncbi.nlm.nih.gov/12237154 DM08VHZ DI DM08VHZ DM08VHZ DN Indirubin-5-sulfonate DM08VHZ MI TTZHY6R DM08VHZ MN Glycogen phosphorylase muscle form (GP) DM08VHZ MT DTT DM08VHZ MA Inhibitor DM08VHZ RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DM08VHZ RU https://pubmed.ncbi.nlm.nih.gov/17139284 DM08VHZ DI DM08VHZ DM08VHZ DN Indirubin-5-sulfonate DM08VHZ MI TT9PCE0 DM08VHZ MN Plasmodium CDK PfPK5 (Malaria PfPK5) DM08VHZ MT DTT DM08VHZ MA Inhibitor DM08VHZ RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DM08VHZ RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMJB876 DI DMJB876 DMJB876 DN Indol-1-yl-methyl-pyridin-4-yl-amine DMJB876 MI TTWG9A4 DMJB876 MN Adrenergic receptor alpha-2A (ADRA2A) DMJB876 MT DTT DMJB876 MA Inhibitor DMJB876 RN Synthesis and structure-activity relationships of N-propyl-N-(4-pyridinyl)-1H-indol-1-amine (besipirdine) and related analogs as potential therapeu... J Med Chem. 1996 Jan 19;39(2):570-81. DMJB876 RU https://pubmed.ncbi.nlm.nih.gov/8558529 DMJB876 DI DMJB876 DMJB876 DN Indol-1-yl-methyl-pyridin-4-yl-amine DMJB876 MI TTWM4TY DMJB876 MN Adrenergic receptor alpha-2B (ADRA2B) DMJB876 MT DTT DMJB876 MA Inhibitor DMJB876 RN Synthesis and structure-activity relationships of N-propyl-N-(4-pyridinyl)-1H-indol-1-amine (besipirdine) and related analogs as potential therapeu... J Med Chem. 1996 Jan 19;39(2):570-81. DMJB876 RU https://pubmed.ncbi.nlm.nih.gov/8558529 DMJB876 DI DMJB876 DMJB876 DN Indol-1-yl-methyl-pyridin-4-yl-amine DMJB876 MI TT2NUT5 DMJB876 MN Adrenergic receptor alpha-2C (ADRA2C) DMJB876 MT DTT DMJB876 MA Inhibitor DMJB876 RN Synthesis and structure-activity relationships of N-propyl-N-(4-pyridinyl)-1H-indol-1-amine (besipirdine) and related analogs as potential therapeu... J Med Chem. 1996 Jan 19;39(2):570-81. DMJB876 RU https://pubmed.ncbi.nlm.nih.gov/8558529 DMR9GNW DI DMR9GNW DMR9GNW DN Indol-1-yl-prop-2-ynyl-pyridin-4-yl-amine DMR9GNW MI TTWG9A4 DMR9GNW MN Adrenergic receptor alpha-2A (ADRA2A) DMR9GNW MT DTT DMR9GNW MA Inhibitor DMR9GNW RN Synthesis and structure-activity relationships of N-propyl-N-(4-pyridinyl)-1H-indol-1-amine (besipirdine) and related analogs as potential therapeu... J Med Chem. 1996 Jan 19;39(2):570-81. DMR9GNW RU https://pubmed.ncbi.nlm.nih.gov/8558529 DMR9GNW DI DMR9GNW DMR9GNW DN Indol-1-yl-prop-2-ynyl-pyridin-4-yl-amine DMR9GNW MI TTWM4TY DMR9GNW MN Adrenergic receptor alpha-2B (ADRA2B) DMR9GNW MT DTT DMR9GNW MA Inhibitor DMR9GNW RN Synthesis and structure-activity relationships of N-propyl-N-(4-pyridinyl)-1H-indol-1-amine (besipirdine) and related analogs as potential therapeu... J Med Chem. 1996 Jan 19;39(2):570-81. DMR9GNW RU https://pubmed.ncbi.nlm.nih.gov/8558529 DMR9GNW DI DMR9GNW DMR9GNW DN Indol-1-yl-prop-2-ynyl-pyridin-4-yl-amine DMR9GNW MI TT2NUT5 DMR9GNW MN Adrenergic receptor alpha-2C (ADRA2C) DMR9GNW MT DTT DMR9GNW MA Inhibitor DMR9GNW RN Synthesis and structure-activity relationships of N-propyl-N-(4-pyridinyl)-1H-indol-1-amine (besipirdine) and related analogs as potential therapeu... J Med Chem. 1996 Jan 19;39(2):570-81. DMR9GNW RU https://pubmed.ncbi.nlm.nih.gov/8558529 DM1F53L DI DM1F53L DM1F53L DN Indol-1-yl-pyridin-4-yl-amine DM1F53L MI TTWG9A4 DM1F53L MN Adrenergic receptor alpha-2A (ADRA2A) DM1F53L MT DTT DM1F53L MA Inhibitor DM1F53L RN Synthesis and structure-activity relationships of N-propyl-N-(4-pyridinyl)-1H-indol-1-amine (besipirdine) and related analogs as potential therapeu... J Med Chem. 1996 Jan 19;39(2):570-81. DM1F53L RU https://pubmed.ncbi.nlm.nih.gov/8558529 DM1F53L DI DM1F53L DM1F53L DN Indol-1-yl-pyridin-4-yl-amine DM1F53L MI TTWM4TY DM1F53L MN Adrenergic receptor alpha-2B (ADRA2B) DM1F53L MT DTT DM1F53L MA Inhibitor DM1F53L RN Synthesis and structure-activity relationships of N-propyl-N-(4-pyridinyl)-1H-indol-1-amine (besipirdine) and related analogs as potential therapeu... J Med Chem. 1996 Jan 19;39(2):570-81. DM1F53L RU https://pubmed.ncbi.nlm.nih.gov/8558529 DM1F53L DI DM1F53L DM1F53L DN Indol-1-yl-pyridin-4-yl-amine DM1F53L MI TT2NUT5 DM1F53L MN Adrenergic receptor alpha-2C (ADRA2C) DM1F53L MT DTT DM1F53L MA Inhibitor DM1F53L RN Synthesis and structure-activity relationships of N-propyl-N-(4-pyridinyl)-1H-indol-1-amine (besipirdine) and related analogs as potential therapeu... J Med Chem. 1996 Jan 19;39(2):570-81. DM1F53L RU https://pubmed.ncbi.nlm.nih.gov/8558529 DMP543H DI DMP543H DMP543H DN INDOLACTUM DMP543H MI TT9WJ8U DMP543H MN Protein kinase C delta (PRKCD) DMP543H MT DTT DMP543H MA Inhibitor DMP543H RN Structural basis of RasGRP binding to high-affinity PKC ligands. J Med Chem. 2002 Feb 14;45(4):853-60. DMP543H RU https://pubmed.ncbi.nlm.nih.gov/11831896 DMEHI15 DI DMEHI15 DMEHI15 DN Indole N -acetamide DMEHI15 MI TT84ETX DMEHI15 MN Human immunodeficiency virus Reverse transcriptase (HIV RT) DMEHI15 MT DTT DMEHI15 MA Inhibitor DMEHI15 RN Emerging antiviral drugs. Expert Opin Emerg Drugs. 2008 Sep;13(3):393-416. DMEHI15 RU https://pubmed.ncbi.nlm.nih.gov/18764719 DMB4ZNW DI DMB4ZNW DMB4ZNW DN Indole Naphthyridinone DMB4ZNW MI TTVTX4N DMB4ZNW MN Bacterial Fatty acid synthetase I (Bact inhA) DMB4ZNW MT DTT DMB4ZNW MA Inhibitor DMB4ZNW RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMB4ZNW RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMB4ZNW DI DMB4ZNW DMB4ZNW DN Indole Naphthyridinone DMB4ZNW MI TTNX2CS DMB4ZNW MN Plasmodium Enoyl-ACP reductase (Malaria fabI) DMB4ZNW MT DTT DMB4ZNW MA Inhibitor DMB4ZNW RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMB4ZNW RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMF0VAG DI DMF0VAG DMF0VAG DN indole-3-propionic acid DMF0VAG MI TTUYIZW DMF0VAG MN Solute carrier family 36 member 1 (SLC36A1) DMF0VAG MT DTT DMF0VAG MA Inhibitor DMF0VAG RN Serotonin, L-tryptophan, and tryptamine are effective inhibitors of the amino acid transport system PAT1. FASEB J. 2005 Sep;19(11):1468-73. DMF0VAG RU https://pubmed.ncbi.nlm.nih.gov/16126914 DMML9AY DI DMML9AY DMML9AY DN Indolin-2-one deriv. 4b DMML9AY MI TTUTJGQ DMML9AY MN Vascular endothelial growth factor receptor 2 (KDR) DMML9AY MT DTT DMML9AY MA Inhibitor DMML9AY RN Identification of substituted 3-[(4,5,6, 7-tetrahydro-1H-indol-2-yl)methylene]-1,3-dihydroindol-2-ones as growth factor receptor inhibitors for VEGF-R2 (Flk-1/KDR), FGF-R1, and PDGF-Rbeta tyrosine kinases. J Med Chem. 2000 Jul 13;43(14):2655-63. DMML9AY RU https://pubmed.ncbi.nlm.nih.gov/10893303 DMSBENK DI DMSBENK DMSBENK DN Indomethacin glucuronide DMSBENK MI DE9RA0I DMSBENK MN Beta-glucuronidase (uidA) DMSBENK MT DME DMSBENK MA Metabolism DMSBENK RN Bidirectional interactions between indomethacin and the murine intestinal microbiota. Elife. 2015 Dec 23;4:e08973. DMSBENK RU https://pubmed.ncbi.nlm.nih.gov/26701907 DMSBENK DI DMSBENK DMSBENK DN Indomethacin glucuronide DMSBENK MI DEGA738 DMSBENK MN Beta-glucuronidase (uidA) DMSBENK MT DME DMSBENK MA Metabolism DMSBENK RN Developing a metagenomic view of xenobiotic metabolism. Pharmacol Res. 2013 Mar;69(1):21-31. DMSBENK RU https://pubmed.ncbi.nlm.nih.gov/22902524 DMSBENK DI DMSBENK DMSBENK DN Indomethacin glucuronide DMSBENK MI DE68SAL DMSBENK MN Beta-glucuronidase (uidA) DMSBENK MT DME DMSBENK MA Metabolism DMSBENK RN Developing a metagenomic view of xenobiotic metabolism. Pharmacol Res. 2013 Mar;69(1):21-31. DMSBENK RU https://pubmed.ncbi.nlm.nih.gov/22902524 DMSBENK DI DMSBENK DMSBENK DN Indomethacin glucuronide DMSBENK MI DEKRUCA DMSBENK MN Beta-glucuronidase (uidA) DMSBENK MT DME DMSBENK MA Metabolism DMSBENK RN Developing a metagenomic view of xenobiotic metabolism. Pharmacol Res. 2013 Mar;69(1):21-31. DMSBENK RU https://pubmed.ncbi.nlm.nih.gov/22902524 DMSBENK DI DMSBENK DMSBENK DN Indomethacin glucuronide DMSBENK MI DE473X0 DMSBENK MN Beta-glucuronidase (uidA) DMSBENK MT DME DMSBENK MA Metabolism DMSBENK RN Developing a metagenomic view of xenobiotic metabolism. Pharmacol Res. 2013 Mar;69(1):21-31. DMSBENK RU https://pubmed.ncbi.nlm.nih.gov/22902524 DMBOQ6M DI DMBOQ6M DMBOQ6M DN INDUS-815B DMBOQ6M MI TTSLUMT DMBOQ6M MN Protein kinase D (PRKD1) DMBOQ6M MT DTT DMBOQ6M MA Modulator DMBOQ6M RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1489). DMBOQ6M RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1489 DMLJ645 DI DMLJ645 DMLJ645 DN INDUS-815C DMLJ645 MI TTLKF5M DMLJ645 MN NAD-dependent deacetylase sirtuin-2 (SIRT2) DMLJ645 MT DTT DMLJ645 MA Inhibitor DMLJ645 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2708). DMLJ645 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2708 DMV6UJ5 DI DMV6UJ5 DMV6UJ5 DN Infractopicrin DMV6UJ5 MI TT1RS9F DMV6UJ5 MN Acetylcholinesterase (AChE) DMV6UJ5 MT DTT DMV6UJ5 MA Inhibitor DMV6UJ5 RN Acetylcholinesterase inhibitors from the toadstool Cortinarius infractus. Bioorg Med Chem. 2010 Mar 15;18(6):2173-2177. DMV6UJ5 RU https://pubmed.ncbi.nlm.nih.gov/20176490 DM487FU DI DM487FU DM487FU DN Ingenol-3-bezoate DM487FU MI TT9WJ8U DM487FU MN Protein kinase C delta (PRKCD) DM487FU MT DTT DM487FU MA Inhibitor DM487FU RN Structural basis of binding of high-affinity ligands to protein kinase C: prediction of the binding modes through a new molecular dynamics method a... J Med Chem. 2001 May 24;44(11):1690-701. DM487FU RU https://pubmed.ncbi.nlm.nih.gov/11356104 DMUQHMP DI DMUQHMP DMUQHMP DN Inhibitor 1 [Colombo et al., 2012] DMUQHMP MI TTWHYC8 DMUQHMP MN Airway trypsin-like protease (TMPRSS11D) DMUQHMP MT DTT DMUQHMP MA Inhibitor DMUQHMP RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2420). DMUQHMP RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2420 DMUQHMP DI DMUQHMP DMUQHMP DN Inhibitor 1 [Colombo et al., 2012] DMUQHMP MI TTPRO7W DMUQHMP MN Suppressor of tumorigenicity 14 protein (ST14) DMUQHMP MT DTT DMUQHMP MA Inhibitor DMUQHMP RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2418). DMUQHMP RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2418 DMUQHMP DI DMUQHMP DMUQHMP DN Inhibitor 1 [Colombo et al., 2012] DMUQHMP MI TTL9KE7 DMUQHMP MN Transmembrane protease serine 6 (TMPRSS6) DMUQHMP MT DTT DMUQHMP MA Inhibitor DMUQHMP RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2422). DMUQHMP RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2422 DMWIHRX DI DMWIHRX DMWIHRX DN inhibitor 19 DMWIHRX MI TTY2KP7 DMWIHRX MN Leucyl-cysteinyl aminopeptidase (LNPEP) DMWIHRX MT DTT DMWIHRX MA Inhibitor DMWIHRX RN Potent macrocyclic inhibitors of insulin-regulated aminopeptidase (IRAP) by olefin ring-closing metathesis. J Med Chem. 2011 Jun 9;54(11):3779-92. DMWIHRX RU https://pubmed.ncbi.nlm.nih.gov/21476495 DMBQY3C DI DMBQY3C DMBQY3C DN Inhibitor Idd 384 DMBQY3C MI TTFBNVI DMBQY3C MN Aldose reductase (AKR1B1) DMBQY3C MT DTT DMBQY3C MA Inhibitor DMBQY3C RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMBQY3C RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMI5N23 DI DMI5N23 DMI5N23 DN IN-N01 DMI5N23 MI TTE4KHA DMI5N23 MN Amyloid beta A4 protein (APP) DMI5N23 MT DTT DMI5N23 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2402). DMI5N23 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2402 DMZEXY9 DI DMZEXY9 DMZEXY9 DN INO-1002 DMZEXY9 MI TTVDSZ0 DMZEXY9 MN Poly [ADP-ribose] polymerase 1 (PARP1) DMZEXY9 MT DTT DMZEXY9 MA Inhibitor DMZEXY9 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2771). DMZEXY9 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2771 DMY65AR DI DMY65AR DMY65AR DN Inosine DMY65AR MI DE1DOKJ DMY65AR MN Cytosolic 5'-nucleotidase II (NT5C2) DMY65AR MT DME DMY65AR MA Metabolism DMY65AR RN Phosphorylation of ribavirin and viramidine by adenosine kinase and cytosolic 5'-nucleotidase II: Implications for ribavirin metabolism in erythrocytes. Antimicrob Agents Chemother. 2005 Jun;49(6):2164-71. DMY65AR RU https://www.ncbi.nlm.nih.gov/pubmed/?term=15917509 DMLR86H DI DMLR86H DMLR86H DN Inosinic Acid DMLR86H MI TTZHY6R DMLR86H MN Glycogen phosphorylase muscle form (GP) DMLR86H MT DTT DMLR86H MA Inhibitor DMLR86H RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMLR86H RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMLR86H DI DMLR86H DMLR86H DN Inosinic Acid DMLR86H MI TTL7C8Q DMLR86H MN Inosine-5'-monophosphate dehydrogenase 1 (IMPDH1) DMLR86H MT DTT DMLR86H MA Inhibitor DMLR86H RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMLR86H RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMLR86H DI DMLR86H DMLR86H DN Inosinic Acid DMLR86H MI TTTB4UP DMLR86H MN Inosine-5'-monophosphate dehydrogenase 2 (IMPDH2) DMLR86H MT DTT DMLR86H MA Inhibitor DMLR86H RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMLR86H RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMLR86H DI DMLR86H DMLR86H DN Inosinic Acid DMLR86H MI TTYQ4AE DMLR86H MN Plasmodium Adenylosuccinate synthetase (Malaria Adss) DMLR86H MT DTT DMLR86H MA Inhibitor DMLR86H RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMLR86H RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMLR86H DI DMLR86H DMLR86H DN Inosinic Acid DMLR86H MI TTBL49X DMLR86H MN Plasmodium Hypoxanthine-guanine phosphoribosyltransferase (Malaria LACZ) DMLR86H MT DTT DMLR86H MA Inhibitor DMLR86H RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMLR86H RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMIFD35 DI DMIFD35 DMIFD35 DN Inositol 1,3,4,5-tetrakisphosphate DMIFD35 MI DE5Q1SP DMIFD35 MN Inositol tetrakisphosphate 3-phosphatase (MIPP) DMIFD35 MT DME DMIFD35 MA Metabolism DMIFD35 RN The human and rat forms of multiple inositol polyphosphate phosphatase: functional homology with a histidine acid phosphatase up-regulated during endochondral ossification. FEBS Lett. 1999 Jan 8;442(1):99-104. DMIFD35 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=9923613 DMIFD35 DI DMIFD35 DMIFD35 DN Inositol 1,3,4,5-tetrakisphosphate DMIFD35 MI TTWTSCV DMIFD35 MN RAC-alpha serine/threonine-protein kinase (AKT1) DMIFD35 MT DTT DMIFD35 MA Inhibitor DMIFD35 RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMIFD35 RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMIFD35 DI DMIFD35 DMIFD35 DN Inositol 1,3,4,5-tetrakisphosphate DMIFD35 MI TTGM6VW DMIFD35 MN Tyrosine-protein kinase BTK (ATK) DMIFD35 MT DTT DMIFD35 MA Inhibitor DMIFD35 RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMIFD35 RU https://pubmed.ncbi.nlm.nih.gov/17139284 DM43G5Z DI DM43G5Z DM43G5Z DN inositol 2,4,5-trisphosphate DM43G5Z MI TT5HWAT DM43G5Z MN IP3 receptor isoform 1 (ITPR1) DM43G5Z MT DTT DM43G5Z MA Activator DM43G5Z RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 743). DM43G5Z RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=743 DM43G5Z DI DM43G5Z DM43G5Z DN inositol 2,4,5-trisphosphate DM43G5Z MI TTK9OV3 DM43G5Z MN IP3 receptor isoform 2 (IP3R2) DM43G5Z MT DTT DM43G5Z MA Activator DM43G5Z RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 744). DM43G5Z RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=744 DMAQU71 DI DMAQU71 DMAQU71 DN Ins(3,4,5,6)P4 DMAQU71 MI TTOJI4S DMAQU71 MN Calcium-dependent chloride channel anoctamin (ANO) DMAQU71 MT DTT DMAQU71 MA Blocker (channel blocker) DMAQU71 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 708). DMAQU71 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=708 DMLZFTH DI DMLZFTH DMLZFTH DN INS48823 DMLZFTH MI TTNVSKA DMLZFTH MN P2Y purinoceptor 6 (P2RY6) DMLZFTH MT DTT DMLZFTH MA Agonist DMLZFTH RN P2 receptors activated by uracil nucleotides--an update. Curr Med Chem. 2006;13(3):289-312. DMLZFTH RU https://pubmed.ncbi.nlm.nih.gov/16475938 DM95BL8 DI DM95BL8 DM95BL8 DN INS49266 DM95BL8 MI TTZ1DT0 DM95BL8 MN P2Y purinoceptor 12 (P2RY12) DM95BL8 MT DTT DM95BL8 MA Antagonist DM95BL8 RN Lipophilic modifications to dinucleoside polyphosphates and nucleotides that confer antagonist properties at the platelet P2Y12 receptor. J Med Chem. 2008 Feb 28;51(4):1007-25. DM95BL8 RU https://pubmed.ncbi.nlm.nih.gov/18232657 DMFU92Z DI DMFU92Z DMFU92Z DN Insulin molecules, Novo DMFU92Z MI TTZOPHG DMFU92Z MN Insulin (INS) DMFU92Z MT DTT DMFU92Z MA Modulator DMFU92Z RN Long-term comparison of human insulin analogue B10Asp and soluble human insulin in IDDM patients on a basal/bolus insulin regimen. Diabetologia. 1995 May;38(5):592-8. DMFU92Z RU https://www.ncbi.nlm.nih.gov/pubmed/7489843 DMTPB8A DI DMTPB8A DMTPB8A DN INT-777 DMTPB8A MI TTSDVTR DMTPB8A MN G-protein coupled bile acid receptor 1 (GPBAR1) DMTPB8A MT DTT DMTPB8A MA Agonist DMTPB8A RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 37). DMTPB8A RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=37 DMB9AIX DI DMB9AIX DMB9AIX DN Interleukin-1-alpha - Amgen/Roche DMB9AIX MI TTPM6HI DMB9AIX MN Interleukin-1 alpha (IL1A) DMB9AIX MT DTT DMB9AIX MA Modulator DMB9AIX RN Identification of regions in interleukin-1 alpha important for activity. J Biol Chem. 1993 Oct 15;268(29):22105-11. DMB9AIX RU https://www.ncbi.nlm.nih.gov/pubmed/8408069 DM3D9XY DI DM3D9XY DM3D9XY DN interleukin-2, Roussel Uclaf DM3D9XY MI TTF89GD DM3D9XY MN Interleukin-2 (IL2) DM3D9XY MT DTT DM3D9XY MA Modulator DM3D9XY RN Randomized study of recombinant interleukin-2 after autologous bone marrow transplantation for acute leukemia in first complete remission. Eur Cytokine Netw. 2000 Mar;11(1):91-8. DM3D9XY RU https://www.ncbi.nlm.nih.gov/pubmed/10705305 DM8BZVI DI DM8BZVI DM8BZVI DN INV-311 DM8BZVI MI TTVCZPI DM8BZVI MN Myeloperoxidase (MPO) DM8BZVI MT DTT DM8BZVI MA Inhibitor DM8BZVI RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2789). DM8BZVI RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2789 DM3FZ6P DI DM3FZ6P DM3FZ6P DN IODIDE DM3FZ6P MI TTHQPL7 DM3FZ6P MN Carbonic anhydrase I (CA-I) DM3FZ6P MT DTT DM3FZ6P MA Inhibitor DM3FZ6P RN Carbonic anhydrase inhibitors. Inhibition of the newly isolated murine isozyme XIII with anions. Bioorg Med Chem Lett. 2004 Nov 1;14(21):5435-9. DM3FZ6P RU https://pubmed.ncbi.nlm.nih.gov/15454240 DM3FZ6P DI DM3FZ6P DM3FZ6P DN IODIDE DM3FZ6P MI TTANPDJ DM3FZ6P MN Carbonic anhydrase II (CA-II) DM3FZ6P MT DTT DM3FZ6P MA Inhibitor DM3FZ6P RN Carbonic anhydrase inhibitors. Inhibition of the newly isolated murine isozyme XIII with anions. Bioorg Med Chem Lett. 2004 Nov 1;14(21):5435-9. DM3FZ6P RU https://pubmed.ncbi.nlm.nih.gov/15454240 DMM4XVL DI DMM4XVL DMM4XVL DN Iodoacetamide DMM4XVL MI TT9INHD DMM4XVL MN Creatine kinase (CK) DMM4XVL MT DTT DMM4XVL MA Inhibitor DMM4XVL RN Creatine kinase inhibitor iodoacetamide antagonizes calcium-stimulated inotropy in cardiomyocytes. Clin Exp Pharmacol Physiol. 2009 Feb;36(2):141-5. DMM4XVL RU https://pubmed.ncbi.nlm.nih.gov/18761665 DM7AHNF DI DM7AHNF DM7AHNF DN iodoaminopotentidine DM7AHNF MI TTQHJ1K DM7AHNF MN Histamine H2 receptor (H2R) DM7AHNF MT DTT DM7AHNF MA Antagonist DM7AHNF RN Heterologous expression of rat epitope-tagged histamine H2 receptors in insect Sf9 cells. Br J Pharmacol. 1997 Nov;122(5):867-74. DM7AHNF RU https://pubmed.ncbi.nlm.nih.gov/9384502 DMOA2J8 DI DMOA2J8 DMOA2J8 DN iodocyanopindolol DMOA2J8 MI TTMXGCW DMOA2J8 MN Adrenergic receptor beta-3 (ADRB3) DMOA2J8 MT DTT DMOA2J8 MA Antagonist DMOA2J8 RN Markedly reduced effects of (-)-isoprenaline but not of (-)-CGP12177 and unchanged affinity of beta-blockers at Gly389-beta1-adrenoceptors compared... Br J Pharmacol. 2004 May;142(1):51-6. DMOA2J8 RU https://pubmed.ncbi.nlm.nih.gov/15037517 DM3BL0G DI DM3BL0G DM3BL0G DN IODOINDOMETHACIN DM3BL0G MI TT8NGED DM3BL0G MN Prostaglandin G/H synthase 1 (COX-1) DM3BL0G MT DTT DM3BL0G MA Inhibitor DM3BL0G RN In silico search for multi-target anti-inflammatories in Chinese herbs and formulas. Bioorg Med Chem. 2010 Mar 15;18(6):2204-2218. DM3BL0G RU https://pubmed.ncbi.nlm.nih.gov/20188577 DMF8EJ6 DI DMF8EJ6 DMF8EJ6 DN Iodo-Phenylalanine DMF8EJ6 MI TTDIGC1 DMF8EJ6 MN Dipeptidyl peptidase 4 (DPP-4) DMF8EJ6 MT DTT DMF8EJ6 MA Inhibitor DMF8EJ6 RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMF8EJ6 RU https://pubmed.ncbi.nlm.nih.gov/17139284 DM0749Z DI DM0749Z DM0749Z DN IODOPRIDE DM0749Z MI TTEX248 DM0749Z MN Dopamine D2 receptor (D2R) DM0749Z MT DTT DM0749Z MA Inhibitor DM0749Z RN Fluorinated and iodinated dopamine agents: D2 imaging agents for PET and SPECT. J Med Chem. 1993 Jan 22;36(2):221-8. DM0749Z RU https://pubmed.ncbi.nlm.nih.gov/8093734 DMDA6VL DI DMDA6VL DMDA6VL DN IODOPROXYFAN DMDA6VL MI TT9JNIC DMDA6VL MN Histamine H3 receptor (H3R) DMDA6VL MT DTT DMDA6VL MA Inhibitor DMDA6VL RN Different antagonist binding properties of human and rat histamine H3 receptors. Bioorg Med Chem Lett. 2001 Apr 9;11(7):951-4. DMDA6VL RU https://pubmed.ncbi.nlm.nih.gov/11294398 DMXYFMB DI DMXYFMB DMXYFMB DN IODOSULPIRIDE DMXYFMB MI TTEX248 DMXYFMB MN Dopamine D2 receptor (D2R) DMXYFMB MT DTT DMXYFMB MA Inhibitor DMXYFMB RN Fluorinated and iodinated dopamine agents: D2 imaging agents for PET and SPECT. J Med Chem. 1993 Jan 22;36(2):221-8. DMXYFMB RU https://pubmed.ncbi.nlm.nih.gov/8093734 DMOE8LT DI DMOE8LT DMOE8LT DN IODOSUPROFEN DMOE8LT MI TT8NGED DMOE8LT MN Prostaglandin G/H synthase 1 (COX-1) DMOE8LT MT DTT DMOE8LT MA Inhibitor DMOE8LT RN In silico search for multi-target anti-inflammatories in Chinese herbs and formulas. Bioorg Med Chem. 2010 Mar 15;18(6):2204-2218. DMOE8LT RU https://pubmed.ncbi.nlm.nih.gov/20188577 DMQMH6S DI DMQMH6S DMQMH6S DN Iodotubercidin DMQMH6S MI TTL732K DMQMH6S MN Adenosine kinase (ADK) DMQMH6S MT DTT DMQMH6S MA Inhibitor DMQMH6S RN Therapeutic target database update 2012: a resource for facilitating target-oriented drug discovery. Nucleic Acids Res. 2012 Jan;40(Database issue):D1128-36. DMQMH6S RU https://pubmed.ncbi.nlm.nih.gov/21948793 DMO73M9 DI DMO73M9 DMO73M9 DN Iodyl-benzene DMO73M9 MI TTELIN2 DMO73M9 MN PTPN1 messenger RNA (PTPN1 mRNA) DMO73M9 MT DTT DMO73M9 MA Inhibitor DMO73M9 RN Periodinates: a new class of protein tyrosine phosphatase inhibitors. Bioorg Med Chem Lett. 1999 Feb 8;9(3):353-6. DMO73M9 RU https://pubmed.ncbi.nlm.nih.gov/10091683 DMYG0M5 DI DMYG0M5 DMYG0M5 DN IOX1 DMYG0M5 MI TT9ISBX DMYG0M5 MN HIF-prolyl hydroxylase 2 (HPH-2) DMYG0M5 MT DTT DMYG0M5 MA Inhibitor DMYG0M5 RN A cell-permeable ester derivative of the JmjC histone demethylase inhibitor IOX1. ChemMedChem. 2014 Mar;9(3):566-71. DMYG0M5 RU https://pubmed.ncbi.nlm.nih.gov/24504543 DMYG0M5 DI DMYG0M5 DMYG0M5 DN IOX1 DMYG0M5 MI TTKXS4A DMYG0M5 MN Lysine-specific demethylase 3A (KDM3A) DMYG0M5 MT DTT DMYG0M5 MA Inhibitor DMYG0M5 RN A cell-permeable ester derivative of the JmjC histone demethylase inhibitor IOX1. ChemMedChem. 2014 Mar;9(3):566-71. DMYG0M5 RU https://pubmed.ncbi.nlm.nih.gov/24504543 DMYG0M5 DI DMYG0M5 DMYG0M5 DN IOX1 DMYG0M5 MI TTV8CRH DMYG0M5 MN Lysine-specific demethylase 4C (KDM4C) DMYG0M5 MT DTT DMYG0M5 MA Inhibitor DMYG0M5 RN A cell-permeable ester derivative of the JmjC histone demethylase inhibitor IOX1. ChemMedChem. 2014 Mar;9(3):566-71. DMYG0M5 RU https://pubmed.ncbi.nlm.nih.gov/24504543 DMYG0M5 DI DMYG0M5 DMYG0M5 DN IOX1 DMYG0M5 MI TTDIJUQ DMYG0M5 MN Lysine-specific demethylase 6B (KDM6B) DMYG0M5 MT DTT DMYG0M5 MA Inhibitor DMYG0M5 RN A cell-permeable ester derivative of the JmjC histone demethylase inhibitor IOX1. ChemMedChem. 2014 Mar;9(3):566-71. DMYG0M5 RU https://pubmed.ncbi.nlm.nih.gov/24504543 DMQ0X7I DI DMQ0X7I DMQ0X7I DN IOX2 DMQ0X7I MI TT9ISBX DMQ0X7I MN HIF-prolyl hydroxylase 2 (HPH-2) DMQ0X7I MT DTT DMQ0X7I MA Inhibitor DMQ0X7I RN Selective small molecule probes for the hypoxia inducible factor (HIF) prolyl hydroxylases. ACS Chem Biol. 2013 Jul 19;8(7):1488-96. DMQ0X7I RU https://pubmed.ncbi.nlm.nih.gov/23683440 DMQ0X7I DI DMQ0X7I DMQ0X7I DN IOX2 DMQ0X7I MI TT8XTY2 DMQ0X7I MN Lysine-specific demethylase 2A (KDM2A) DMQ0X7I MT DTT DMQ0X7I MA Inhibitor DMQ0X7I RN Selective small molecule probes for the hypoxia inducible factor (HIF) prolyl hydroxylases. ACS Chem Biol. 2013 Jul 19;8(7):1488-96. DMQ0X7I RU https://pubmed.ncbi.nlm.nih.gov/23683440 DMQ0X7I DI DMQ0X7I DMQ0X7I DN IOX2 DMQ0X7I MI TT94UCF DMQ0X7I MN Lysine-specific demethylase 5C (KDM5C) DMQ0X7I MT DTT DMQ0X7I MA Inhibitor DMQ0X7I RN Selective small molecule probes for the hypoxia inducible factor (HIF) prolyl hydroxylases. ACS Chem Biol. 2013 Jul 19;8(7):1488-96. DMQ0X7I RU https://pubmed.ncbi.nlm.nih.gov/23683440 DMIX7CP DI DMIX7CP DMIX7CP DN IP-1200 DMIX7CP MI TT9B4N3 DMIX7CP MN Prostaglandin receptor (PTGR) DMIX7CP MT DTT DMIX7CP MA Modulator DMIX7CP RN Clinical pipeline report, company report or official report of Immunologic. DMIX7CP RU http://www.immunologic.nl/products/antibodies/i/ DMB2YXN DI DMB2YXN DMB2YXN DN Ip5I DMB2YXN MI TTJW7B3 DMB2YXN MN P2X purinoceptor 1 (P2RX1) DMB2YXN MT DTT DMB2YXN MA Antagonist DMB2YXN RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 478). DMB2YXN RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=478 DM6OHVU DI DM6OHVU DM6OHVU DN iperoxo DM6OHVU MI TTOXS3C DM6OHVU MN Muscarinic acetylcholine receptor (CHRM) DM6OHVU MT DTT DM6OHVU MA Agonist DM6OHVU RN Agonists with supraphysiological efficacy at the muscarinic M2 ACh receptor. Br J Pharmacol. 2013 May;169(2):357-70. DM6OHVU RU https://pubmed.ncbi.nlm.nih.gov/23062057 DM42ENF DI DM42ENF DM42ENF DN IPRONIAZIDE DM42ENF MI TT3WG5C DM42ENF MN Monoamine oxidase type A (MAO-A) DM42ENF MT DTT DM42ENF MA Inhibitor DM42ENF RN Design of novel nicotinamides as potent and selective monoamine oxidase a inhibitors. Bioorg Med Chem. 2010 Feb 15;18(4):1659-64. DM42ENF RU https://pubmed.ncbi.nlm.nih.gov/20117937 DM42ENF DI DM42ENF DM42ENF DN IPRONIAZIDE DM42ENF MI TTGP7BY DM42ENF MN Monoamine oxidase type B (MAO-B) DM42ENF MT DTT DM42ENF MA Inhibitor DM42ENF RN Design of novel nicotinamides as potent and selective monoamine oxidase a inhibitors. Bioorg Med Chem. 2010 Feb 15;18(4):1659-64. DM42ENF RU https://pubmed.ncbi.nlm.nih.gov/20117937 DM0T8ZU DI DM0T8ZU DM0T8ZU DN IPS-01003 DM0T8ZU MI TTGKNB4 DM0T8ZU MN Epidermal growth factor receptor (EGFR) DM0T8ZU MT DTT DM0T8ZU MA Antagonist DM0T8ZU RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1797). DM0T8ZU RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1797 DMYEM59 DI DMYEM59 DMYEM59 DN Ipsalazide DMYEM59 MI DEEHWOG DMYEM59 MN Azoreductase (azoR) DMYEM59 MT DME DMYEM59 MA Metabolism DMYEM59 RN Studies of two novel sulfasalazine analogs, ipsalazide and balsalazide. Dig Dis Sci. 1983 Jul;28(7):609-15. DMYEM59 RU https://pubmed.ncbi.nlm.nih.gov/6345112 DM2MXIK DI DM2MXIK DM2MXIK DN IQM-97423 DM2MXIK MI TTCG0AL DM2MXIK MN Cholecystokinin receptor type A (CCKAR) DM2MXIK MT DTT DM2MXIK MA Antagonist DM2MXIK RN Pharmacological study of IQM-97,423, a potent and selective CCK1 receptor antagonist with protective effect in experimental acute pancreatitis. Pharmacology. 2004 Oct;72(2):68-76. DM2MXIK RU https://pubmed.ncbi.nlm.nih.gov/15331911 DMOQBGP DI DMOQBGP DMOQBGP DN IRAK-1/4 inhibitor DMOQBGP MI TTXAJWN DMOQBGP MN IL-1 receptor-associated kinase 1 (IRAK1) DMOQBGP MT DTT DMOQBGP MA Inhibitor DMOQBGP RN Discovery and initial SAR of inhibitors of interleukin-1 receptor-associated kinase-4. Bioorg Med Chem Lett. 2006 Jun 1;16(11):2842-5. DMOQBGP RU https://pubmed.ncbi.nlm.nih.gov/16563752 DMOQBGP DI DMOQBGP DMOQBGP DN IRAK-1/4 inhibitor DMOQBGP MI TTKFVXR DMOQBGP MN Renal carcinoma antigen NY-REN-64 (IRAK-4) DMOQBGP MT DTT DMOQBGP MA Inhibitor DMOQBGP RN Discovery and initial SAR of inhibitors of interleukin-1 receptor-associated kinase-4. Bioorg Med Chem Lett. 2006 Jun 1;16(11):2842-5. DMOQBGP RU https://pubmed.ncbi.nlm.nih.gov/16563752 DMC80TA DI DMC80TA DMC80TA DN IRAK4 inhibitor 4b DMC80TA MI TTKFVXR DMC80TA MN Renal carcinoma antigen NY-REN-64 (IRAK-4) DMC80TA MT DTT DMC80TA MA Inhibitor DMC80TA RN IRAK-4 inhibitors. Part 1: a series of amides. Bioorg Med Chem Lett. 2008 Jun 1;18(11):3211-4. DMC80TA RU https://pubmed.ncbi.nlm.nih.gov/18474425 DM1XHNW DI DM1XHNW DM1XHNW DN IRAK4 inhibitor rac-45 DM1XHNW MI TTKFVXR DM1XHNW MN Renal carcinoma antigen NY-REN-64 (IRAK-4) DM1XHNW MT DTT DM1XHNW MA Inhibitor DM1XHNW RN IRAK-4 inhibitors. Part III: a series of imidazo[1,2-a]pyridines. Bioorg Med Chem Lett. 2008 Jun 15;18(12):3656-60. DM1XHNW RU https://pubmed.ncbi.nlm.nih.gov/18501603 DM5S7IG DI DM5S7IG DM5S7IG DN Irbesartan DM5S7IG MI TTPKMXQ DM5S7IG MN HUMAN type-1 angiotensin II receptor (AGTR1) DM5S7IG MT DTT DM5S7IG MA Antagonist DM5S7IG RN Angiotensin receptor blockers as tentative SARS-CoV-2 therapeutics. Drug Dev Res. 2020 Mar 4. DM5S7IG RU https://pubmed.ncbi.nlm.nih.gov/32129518 DMMGQZ8 DI DMMGQZ8 DMMGQZ8 DN IRL-1722 DMMGQZ8 MI TT3ZTGU DMMGQZ8 MN Endothelin B receptor (EDNRB) DMMGQZ8 MT DTT DMMGQZ8 MA Inhibitor DMMGQZ8 RN IRL 2500: A potent ETB selective endothelin antagonist, Bioorg. Med. Chem. Lett. 6(19):2323-2328 (1996). DMMGQZ8 RU http://www.sciencedirect.com/science/article/pii/0960894X96004210 DML0S7V DI DML0S7V DML0S7V DN IRL-1841 DML0S7V MI TT3ZTGU DML0S7V MN Endothelin B receptor (EDNRB) DML0S7V MT DTT DML0S7V MA Inhibitor DML0S7V RN IRL 2500: A potent ETB selective endothelin antagonist, Bioorg. Med. Chem. Lett. 6(19):2323-2328 (1996). DML0S7V RU http://www.sciencedirect.com/science/article/pii/0960894X96004210 DMNF70P DI DMNF70P DMNF70P DN IS1 DMNF70P MI TTB9CIL DMNF70P MN Prokineticin receptor-1 (PROKR1) DMNF70P MT DTT DMNF70P MA Agonist DMNF70P RN Discovery and cardioprotective effects of the first non-Peptide agonists of the G protein-coupled prokineticin receptor-1. PLoS One. 2015 Apr 1;10(4):e0121027. DMNF70P RU https://pubmed.ncbi.nlm.nih.gov/25831128 DMQ5GA9 DI DMQ5GA9 DMQ5GA9 DN IS20 DMQ5GA9 MI TTB9CIL DMQ5GA9 MN Prokineticin receptor-1 (PROKR1) DMQ5GA9 MT DTT DMQ5GA9 MA Agonist DMQ5GA9 RN Discovery and cardioprotective effects of the first non-Peptide agonists of the G protein-coupled prokineticin receptor-1. PLoS One. 2015 Apr 1;10(4):e0121027. DMQ5GA9 RU https://pubmed.ncbi.nlm.nih.gov/25831128 DMXPMA6 DI DMXPMA6 DMXPMA6 DN IS20I DMXPMA6 MI TT69TQN DMXPMA6 MN Integrin alpha-V/beta-3 (ITGAV/B3) DMXPMA6 MT DTT DMXPMA6 MA Antagonist DMXPMA6 RN IS20I, a specific alphavbeta3 integrin inhibitor, reduces glioma growth in vivo. Neurosurgery. 2003 Jan;52(1):177-85; discussion 185-6. DMXPMA6 RU https://pubmed.ncbi.nlm.nih.gov/12493116 DMU6QXV DI DMU6QXV DMU6QXV DN ISA-2011B DMU6QXV MI TTA7DU1 DMU6QXV MN PtdIns(4)P-5-kinase 1 alpha (PIP5K1A) DMU6QXV MT DTT DMU6QXV MA Inhibitor DMU6QXV RN The role of PI3K/AKT-related PIP5K1alpha and the discovery of its selective inhibitor for treatment of advanced prostate cancer. Proc Natl Acad Sci U S A. 2014 Sep 2;111(35):E3689-98. DMU6QXV RU https://pubmed.ncbi.nlm.nih.gov/25071204 DMD6U4F DI DMD6U4F DMD6U4F DN ISAINDIGOTONE DMD6U4F MI TTSJ6Q4 DMD6U4F MN LOX-5 messenger RNA (ALOX5 mRNA) DMD6U4F MT DTT DMD6U4F MA Inhibitor DMD6U4F RN Inhibition of leukocyte functions by the alkaloid isaindigotone from Isatis indigotica and some new synthetic derivatives. J Nat Prod. 2001 Oct;64(10):1297-300. DMD6U4F RU https://pubmed.ncbi.nlm.nih.gov/11678654 DMJ2FQA DI DMJ2FQA DMJ2FQA DN I-SAP DMJ2FQA MI TT2O84V DMJ2FQA MN Thromboxane A2 receptor (TBXA2R) DMJ2FQA MT DTT DMJ2FQA MA Antagonist DMJ2FQA RN 7-[(1R,2S,3S,5R)-6,6-dimethyl-3-(4- iodobenzenesulfonylamino)bicyclo[3.1.1]hept-2-yl]-5(Z)-heptenoic acid: a novel high-affinity radiolabeled antagonist for platelet thromboxane A2/prostaglandin H2 receptors. J Pharmacol Exp Ther. 1992 Aug;262(2):632-7. DMJ2FQA RU https://pubmed.ncbi.nlm.nih.gov/1386885 DMH6YVD DI DMH6YVD DMH6YVD DN ISC-4 DMH6YVD MI TTAZ05C DMH6YVD MN RAC-gamma serine/threonine-protein kinase (AKT3) DMH6YVD MT DTT DMH6YVD MA Inhibitor DMH6YVD RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2286). DMH6YVD RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2286 DMM2I9G DI DMM2I9G DMM2I9G DN ischemin DMM2I9G MI TTFRCTK DMM2I9G MN CREB-binding protein (CREBBP) DMM2I9G MT DTT DMM2I9G MA Inhibitor DMM2I9G RN A small molecule binding to the coactivator CREB-binding protein blocks apoptosis in cardiomyocytes. Chem Biol. 2011 Apr 22;18(4):531-41. DMM2I9G RU https://pubmed.ncbi.nlm.nih.gov/21513889 DMIB6JL DI DMIB6JL DMIB6JL DN ISIS 100742 DMIB6JL MI TTVXEGU DMIB6JL MN ADAM10 messenger RNA (ADAM10 mRNA) DMIB6JL MT DTT DMIB6JL RN US patent application no. 6,228,648, Antisense modulation of ADAM10 expression. DMIB6JL RU http://www.patentbuddy.com/Patent/6228648?ft=true&sr=true DMI7PGZ DI DMI7PGZ DMI7PGZ DN ISIS 100743 DMI7PGZ MI TTVXEGU DMI7PGZ MN ADAM10 messenger RNA (ADAM10 mRNA) DMI7PGZ MT DTT DMI7PGZ RN US patent application no. 6,228,648, Antisense modulation of ADAM10 expression. DMI7PGZ RU http://www.patentbuddy.com/Patent/6228648?ft=true&sr=true DMFW5VK DI DMFW5VK DMFW5VK DN ISIS 100748 DMFW5VK MI TTVXEGU DMFW5VK MN ADAM10 messenger RNA (ADAM10 mRNA) DMFW5VK MT DTT DMFW5VK RN US patent application no. 6,228,648, Antisense modulation of ADAM10 expression. DMFW5VK RU http://www.patentbuddy.com/Patent/6228648?ft=true&sr=true DMSMJ37 DI DMSMJ37 DMSMJ37 DN ISIS 100749 DMSMJ37 MI TTVXEGU DMSMJ37 MN ADAM10 messenger RNA (ADAM10 mRNA) DMSMJ37 MT DTT DMSMJ37 RN US patent application no. 6,228,648, Antisense modulation of ADAM10 expression. DMSMJ37 RU http://www.patentbuddy.com/Patent/6228648?ft=true&sr=true DMFJES5 DI DMFJES5 DMFJES5 DN ISIS 100750 DMFJES5 MI TTVXEGU DMFJES5 MN ADAM10 messenger RNA (ADAM10 mRNA) DMFJES5 MT DTT DMFJES5 RN US patent application no. 6,228,648, Antisense modulation of ADAM10 expression. DMFJES5 RU http://www.patentbuddy.com/Patent/6228648?ft=true&sr=true DMZV5A7 DI DMZV5A7 DMZV5A7 DN ISIS 100913 DMZV5A7 MI TTW8TJI DMZV5A7 MN MEKK1 messenger RNA (MAP3K1 mRNA) DMZV5A7 MT DTT DMZV5A7 RN US patent application no. 6,168,950, Antisense modulation of MEKK1 expression. DMZV5A7 RU http://www.patentbuddy.com/Patent/6168950?ft=true&sr=true DMUMVIF DI DMUMVIF DMUMVIF DN ISIS 100929 DMUMVIF MI TTW8TJI DMUMVIF MN MEKK1 messenger RNA (MAP3K1 mRNA) DMUMVIF MT DTT DMUMVIF RN US patent application no. 6,168,950, Antisense modulation of MEKK1 expression. DMUMVIF RU http://www.patentbuddy.com/Patent/6168950?ft=true&sr=true DMHUC1X DI DMHUC1X DMHUC1X DN ISIS 100935 DMHUC1X MI TTW8TJI DMHUC1X MN MEKK1 messenger RNA (MAP3K1 mRNA) DMHUC1X MT DTT DMHUC1X RN US patent application no. 6,168,950, Antisense modulation of MEKK1 expression. DMHUC1X RU http://www.patentbuddy.com/Patent/6168950?ft=true&sr=true DM67Q3C DI DM67Q3C DM67Q3C DN ISIS 100939 DM67Q3C MI TTW8TJI DM67Q3C MN MEKK1 messenger RNA (MAP3K1 mRNA) DM67Q3C MT DTT DM67Q3C RN US patent application no. 6,168,950, Antisense modulation of MEKK1 expression. DM67Q3C RU http://www.patentbuddy.com/Patent/6168950?ft=true&sr=true DMS6JD4 DI DMS6JD4 DMS6JD4 DN ISIS 101952 DMS6JD4 MI TTON5JB DMS6JD4 MN MADH6 messenger RNA (MADH6 mRNA) DMS6JD4 MT DTT DMS6JD4 RN US patent application no. 6,277,636, Antisense inhibition of MADH6 expression. DMS6JD4 RU http://www.patentbuddy.com/Patent/6277636?ft=true&sr=true DMEWXR2 DI DMEWXR2 DMEWXR2 DN ISIS 101960 DMEWXR2 MI TTON5JB DMEWXR2 MN MADH6 messenger RNA (MADH6 mRNA) DMEWXR2 MT DTT DMEWXR2 RN US patent application no. 6,277,636, Antisense inhibition of MADH6 expression. DMEWXR2 RU http://www.patentbuddy.com/Patent/6277636?ft=true&sr=true DMV9PI7 DI DMV9PI7 DMV9PI7 DN ISIS 101983 DMV9PI7 MI TTON5JB DMV9PI7 MN MADH6 messenger RNA (MADH6 mRNA) DMV9PI7 MT DTT DMV9PI7 RN US patent application no. 6,277,636, Antisense inhibition of MADH6 expression. DMV9PI7 RU http://www.patentbuddy.com/Patent/6277636?ft=true&sr=true DMYZ5CX DI DMYZ5CX DMYZ5CX DN ISIS 101984 DMYZ5CX MI TTON5JB DMYZ5CX MN MADH6 messenger RNA (MADH6 mRNA) DMYZ5CX MT DTT DMYZ5CX RN US patent application no. 6,277,636, Antisense inhibition of MADH6 expression. DMYZ5CX RU http://www.patentbuddy.com/Patent/6277636?ft=true&sr=true DM8CN2M DI DM8CN2M DM8CN2M DN ISIS 101985 DM8CN2M MI TTON5JB DM8CN2M MN MADH6 messenger RNA (MADH6 mRNA) DM8CN2M MT DTT DM8CN2M RN US patent application no. 6,277,636, Antisense inhibition of MADH6 expression. DM8CN2M RU http://www.patentbuddy.com/Patent/6277636?ft=true&sr=true DM5PTQX DI DM5PTQX DM5PTQX DN ISIS 101986 DM5PTQX MI TTON5JB DM5PTQX MN MADH6 messenger RNA (MADH6 mRNA) DM5PTQX MT DTT DM5PTQX RN US patent application no. 6,277,636, Antisense inhibition of MADH6 expression. DM5PTQX RU http://www.patentbuddy.com/Patent/6277636?ft=true&sr=true DMWCK8Q DI DMWCK8Q DMWCK8Q DN ISIS 101987 DMWCK8Q MI TTON5JB DMWCK8Q MN MADH6 messenger RNA (MADH6 mRNA) DMWCK8Q MT DTT DMWCK8Q RN US patent application no. 6,277,636, Antisense inhibition of MADH6 expression. DMWCK8Q RU http://www.patentbuddy.com/Patent/6277636?ft=true&sr=true DM3EMLB DI DM3EMLB DM3EMLB DN ISIS 101995 DM3EMLB MI TTON5JB DM3EMLB MN MADH6 messenger RNA (MADH6 mRNA) DM3EMLB MT DTT DM3EMLB RN US patent application no. 6,277,636, Antisense inhibition of MADH6 expression. 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J Med Chem. 1982 Mar;25(3):197-207. DM46F5X RU https://pubmed.ncbi.nlm.nih.gov/6279840 DM46F5X DI DM46F5X DM46F5X DN isobutylmethylxanthine DM46F5X MI TTJFY5U DM46F5X MN Adenosine A3 receptor (ADORA3) DM46F5X MT DTT DM46F5X MA Inhibitor DM46F5X RN Adenosine receptors: targets for future drugs. J Med Chem. 1982 Mar;25(3):197-207. DM46F5X RU https://pubmed.ncbi.nlm.nih.gov/6279840 DM46F5X DI DM46F5X DM46F5X DN isobutylmethylxanthine DM46F5X MI TTHQENC DM46F5X MN Phosphodiesterase 1 (PDE1) DM46F5X MT DTT DM46F5X MA Inhibitor DM46F5X RN A new generation of phosphodiesterase inhibitors: multiple molecular forms of phosphodiesterase and the potential for drug selectivity. J Med Chem. 1985 May;28(5):537-45. DM46F5X RU https://pubmed.ncbi.nlm.nih.gov/2985781 DM46F5X DI DM46F5X DM46F5X DN isobutylmethylxanthine DM46F5X MI TTJGW1Z DM46F5X MN Phosphodiesterase 2A (PDE2A) DM46F5X MT DTT DM46F5X MA Inhibitor DM46F5X RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DM46F5X RU https://pubmed.ncbi.nlm.nih.gov/10592235 DM46F5X DI DM46F5X DM46F5X DN isobutylmethylxanthine DM46F5X MI TT06AWU DM46F5X MN Phosphodiesterase 3A (PDE3A) DM46F5X MT DTT DM46F5X MA Inhibitor DM46F5X RN A new generation of phosphodiesterase inhibitors: multiple molecular forms of phosphodiesterase and the potential for drug selectivity. J Med Chem. 1985 May;28(5):537-45. DM46F5X RU https://pubmed.ncbi.nlm.nih.gov/2985781 DM46F5X DI DM46F5X DM46F5X DN isobutylmethylxanthine DM46F5X MI TTZ97H5 DM46F5X MN Phosphodiesterase 4A (PDE4A) DM46F5X MT DTT DM46F5X MA Inhibitor DM46F5X RN A new generation of phosphodiesterase inhibitors: multiple molecular forms of phosphodiesterase and the potential for drug selectivity. J Med Chem. 1985 May;28(5):537-45. DM46F5X RU https://pubmed.ncbi.nlm.nih.gov/2985781 DM46F5X DI DM46F5X DM46F5X DN isobutylmethylxanthine DM46F5X MI TTVIAT9 DM46F5X MN Phosphodiesterase 4B (PDE4B) DM46F5X MT DTT DM46F5X MA Inhibitor DM46F5X RN A new generation of phosphodiesterase inhibitors: multiple molecular forms of phosphodiesterase and the potential for drug selectivity. J Med Chem. 1985 May;28(5):537-45. DM46F5X RU https://pubmed.ncbi.nlm.nih.gov/2985781 DM46F5X DI DM46F5X DM46F5X DN isobutylmethylxanthine DM46F5X MI TTSKMI8 DM46F5X MN Phosphodiesterase 4D (PDE4D) DM46F5X MT DTT DM46F5X MA Inhibitor DM46F5X RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DM46F5X RU https://pubmed.ncbi.nlm.nih.gov/10592235 DM46F5X DI DM46F5X DM46F5X DN isobutylmethylxanthine DM46F5X MI TTJ0IQB DM46F5X MN Phosphodiesterase 5A (PDE5A) DM46F5X MT DTT DM46F5X MA Inhibitor DM46F5X RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DM46F5X RU https://pubmed.ncbi.nlm.nih.gov/10592235 DMX4VY9 DI DMX4VY9 DMX4VY9 DN isobutyric acid DMX4VY9 MI TT0FYAN DMX4VY9 MN Free fatty acid receptor 2 (FFAR2) DMX4VY9 MT DTT DMX4VY9 MA Agonist DMX4VY9 RN Functional characterization of human receptors for short chain fatty acids and their role in polymorphonuclear cell activation. J Biol Chem. 2003 Jul 11;278(28):25481-9. DMX4VY9 RU https://pubmed.ncbi.nlm.nih.gov/12711604 DMX4VY9 DI DMX4VY9 DMX4VY9 DN isobutyric acid DMX4VY9 MI TTXDOHN DMX4VY9 MN Free fatty acid receptor 3 (FFAR3) DMX4VY9 MT DTT DMX4VY9 MA Agonist DMX4VY9 RN Short-chain fatty acids stimulate leptin production in adipocytes through the G protein-coupled receptor GPR41. Proc Natl Acad Sci U S A. 2004 Jan 27;101(4):1045-50. DMX4VY9 RU https://pubmed.ncbi.nlm.nih.gov/14722361 DM861DU DI DM861DU DM861DU DN Iso-caffeine DM861DU MI TTV5CGO DM861DU MN Phosphodiesterase 4 (PDE4) DM861DU MT DTT DM861DU MA Inhibitor DM861DU RN Ocular hypotension induced by topical dopaminergic drugs and phosphodiesterase inhibitors. Eur J Pharmacol. 1994 Jun 2;258(1-2):85-94. DM861DU RU https://pubmed.ncbi.nlm.nih.gov/7925603 DMZR7W6 DI DMZR7W6 DMZR7W6 DN isocarbacyclin DMZR7W6 MI TTOFYT1 DMZR7W6 MN Prostacyclin receptor (PTGIR) DMZR7W6 MT DTT DMZR7W6 MA Agonist DMZR7W6 RN Ligand binding specificities of the eight types and subtypes of the mouse prostanoid receptors expressed in Chinese hamster ovary cells. Br J Pharmacol. 1997 Sep;122(2):217-24. DMZR7W6 RU https://pubmed.ncbi.nlm.nih.gov/9313928 DMZR7W6 DI DMZR7W6 DMZR7W6 DN isocarbacyclin DMZR7W6 MI TT1ZAVI DMZR7W6 MN Prostaglandin E2 receptor EP2 (PTGER2) DMZR7W6 MT DTT DMZR7W6 MA Agonist DMZR7W6 RN Ligand binding specificities of the eight types and subtypes of the mouse prostanoid receptors expressed in Chinese hamster ovary cells. Br J Pharmacol. 1997 Sep;122(2):217-24. DMZR7W6 RU https://pubmed.ncbi.nlm.nih.gov/9313928 DMZR7W6 DI DMZR7W6 DMZR7W6 DN isocarbacyclin DMZR7W6 MI TTPNGDE DMZR7W6 MN Prostaglandin E2 receptor EP3 (PTGER3) DMZR7W6 MT DTT DMZR7W6 MA Agonist DMZR7W6 RN Ligand binding specificities of the eight types and subtypes of the mouse prostanoid receptors expressed in Chinese hamster ovary cells. Br J Pharmacol. 1997 Sep;122(2):217-24. DMZR7W6 RU https://pubmed.ncbi.nlm.nih.gov/9313928 DMUB187 DI DMUB187 DMUB187 DN Isochroman mono-carboxylic acid DMUB187 MI TTELIN2 DMUB187 MN PTPN1 messenger RNA (PTPN1 mRNA) DMUB187 MT DTT DMUB187 MA Inhibitor DMUB187 RN Synthesis and evaluation of some novel dibenzo[b,d]furan carboxylic acids as potential anti-diabetic agents. Eur J Med Chem. 2010 Sep;45(9):3709-18. DMUB187 RU https://pubmed.ncbi.nlm.nih.gov/20627471 DMJKW4S DI DMJKW4S DMJKW4S DN Isocitric Acid DMJKW4S MI TTMTF2P DMJKW4S MN Citrate hydro-lyase (ACO2) DMJKW4S MT DTT DMJKW4S MA Inhibitor DMJKW4S RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMJKW4S RU https://pubmed.ncbi.nlm.nih.gov/17139284 DM52CPU DI DM52CPU DM52CPU DN ISOCLOZAPINE DM52CPU MI TTJQOD7 DM52CPU MN 5-HT 2A receptor (HTR2A) DM52CPU MT DTT DM52CPU MA Inhibitor DM52CPU RN Synthesis and pharmacological evaluation of triflate-substituted analogues of clozapine: identification of a novel atypical neuroleptic. J Med Chem. 1997 Dec 5;40(25):4146-53. DM52CPU RU https://pubmed.ncbi.nlm.nih.gov/9406603 DM52CPU DI DM52CPU DM52CPU DN ISOCLOZAPINE DM52CPU MI TTNGILX DM52CPU MN Adrenergic receptor alpha-1A (ADRA1A) DM52CPU MT DTT DM52CPU MA Inhibitor DM52CPU RN Synthesis and pharmacological evaluation of triflate-substituted analogues of clozapine: identification of a novel atypical neuroleptic. J Med Chem. 1997 Dec 5;40(25):4146-53. DM52CPU RU https://pubmed.ncbi.nlm.nih.gov/9406603 DM52CPU DI DM52CPU DM52CPU DN ISOCLOZAPINE DM52CPU MI TTBRKXS DM52CPU MN Adrenergic receptor alpha-1B (ADRA1B) DM52CPU MT DTT DM52CPU MA Inhibitor DM52CPU RN Synthesis and pharmacological evaluation of triflate-substituted analogues of clozapine: identification of a novel atypical neuroleptic. J Med Chem. 1997 Dec 5;40(25):4146-53. DM52CPU RU https://pubmed.ncbi.nlm.nih.gov/9406603 DM52CPU DI DM52CPU DM52CPU DN ISOCLOZAPINE DM52CPU MI TT34BHT DM52CPU MN Adrenergic receptor alpha-1D (ADRA1D) DM52CPU MT DTT DM52CPU MA Inhibitor DM52CPU RN Synthesis and pharmacological evaluation of triflate-substituted analogues of clozapine: identification of a novel atypical neuroleptic. J Med Chem. 1997 Dec 5;40(25):4146-53. DM52CPU RU https://pubmed.ncbi.nlm.nih.gov/9406603 DM52CPU DI DM52CPU DM52CPU DN ISOCLOZAPINE DM52CPU MI TTZFYLI DM52CPU MN Dopamine D1 receptor (D1R) DM52CPU MT DTT DM52CPU MA Inhibitor DM52CPU RN Synthesis and pharmacological evaluation of triflate-substituted analogues of clozapine: identification of a novel atypical neuroleptic. J Med Chem. 1997 Dec 5;40(25):4146-53. DM52CPU RU https://pubmed.ncbi.nlm.nih.gov/9406603 DM52CPU DI DM52CPU DM52CPU DN ISOCLOZAPINE DM52CPU MI TTEX248 DM52CPU MN Dopamine D2 receptor (D2R) DM52CPU MT DTT DM52CPU MA Inhibitor DM52CPU RN Synthesis and pharmacological evaluation of triflate-substituted analogues of clozapine: identification of a novel atypical neuroleptic. J Med Chem. 1997 Dec 5;40(25):4146-53. DM52CPU RU https://pubmed.ncbi.nlm.nih.gov/9406603 DM52CPU DI DM52CPU DM52CPU DN ISOCLOZAPINE DM52CPU MI TT4C8EA DM52CPU MN Dopamine D3 receptor (D3R) DM52CPU MT DTT DM52CPU MA Inhibitor DM52CPU RN Affinity of 10-(4-methylpiperazino)dibenz[b,f]oxepins for clozapine and spiroperidol binding sites in rat brain. J Med Chem. 1982 Jul;25(7):855-8. DM52CPU RU https://pubmed.ncbi.nlm.nih.gov/7108902 DM52CPU DI DM52CPU DM52CPU DN ISOCLOZAPINE DM52CPU MI TTE0A2F DM52CPU MN Dopamine D4 receptor (D4R) DM52CPU MT DTT DM52CPU MA Inhibitor DM52CPU RN Affinity of 10-(4-methylpiperazino)dibenz[b,f]oxepins for clozapine and spiroperidol binding sites in rat brain. J Med Chem. 1982 Jul;25(7):855-8. DM52CPU RU https://pubmed.ncbi.nlm.nih.gov/7108902 DM52CPU DI DM52CPU DM52CPU DN ISOCLOZAPINE DM52CPU MI TTS2PH3 DM52CPU MN Dopamine D5 receptor (D5R) DM52CPU MT DTT DM52CPU MA Inhibitor DM52CPU RN Affinity of 10-(4-methylpiperazino)dibenz[b,f]oxepins for clozapine and spiroperidol binding sites in rat brain. J Med Chem. 1982 Jul;25(7):855-8. DM52CPU RU https://pubmed.ncbi.nlm.nih.gov/7108902 DM52CPU DI DM52CPU DM52CPU DN ISOCLOZAPINE DM52CPU MI TTZ9SOR DM52CPU MN Muscarinic acetylcholine receptor M1 (CHRM1) DM52CPU MT DTT DM52CPU MA Inhibitor DM52CPU RN Chloro-substituted, sterically hindered 5,11-dicarbo analogues of clozapine as potential chiral antipsychotic agents. J Med Chem. 1990 Feb;33(2):809-14. DM52CPU RU https://pubmed.ncbi.nlm.nih.gov/1967652 DM52CPU DI DM52CPU DM52CPU DN ISOCLOZAPINE DM52CPU MI TTYEG6Q DM52CPU MN Muscarinic acetylcholine receptor M2 (CHRM2) DM52CPU MT DTT DM52CPU MA Inhibitor DM52CPU RN Chloro-substituted, sterically hindered 5,11-dicarbo analogues of clozapine as potential chiral antipsychotic agents. J Med Chem. 1990 Feb;33(2):809-14. DM52CPU RU https://pubmed.ncbi.nlm.nih.gov/1967652 DM52CPU DI DM52CPU DM52CPU DN ISOCLOZAPINE DM52CPU MI TTQ13Z5 DM52CPU MN Muscarinic acetylcholine receptor M3 (CHRM3) DM52CPU MT DTT DM52CPU MA Inhibitor DM52CPU RN Chloro-substituted, sterically hindered 5,11-dicarbo analogues of clozapine as potential chiral antipsychotic agents. J Med Chem. 1990 Feb;33(2):809-14. DM52CPU RU https://pubmed.ncbi.nlm.nih.gov/1967652 DM52CPU DI DM52CPU DM52CPU DN ISOCLOZAPINE DM52CPU MI TTQ3JTF DM52CPU MN Muscarinic acetylcholine receptor M4 (CHRM4) DM52CPU MT DTT DM52CPU MA Inhibitor DM52CPU RN Chloro-substituted, sterically hindered 5,11-dicarbo analogues of clozapine as potential chiral antipsychotic agents. J Med Chem. 1990 Feb;33(2):809-14. DM52CPU RU https://pubmed.ncbi.nlm.nih.gov/1967652 DM52CPU DI DM52CPU DM52CPU DN ISOCLOZAPINE DM52CPU MI TTH18TF DM52CPU MN Muscarinic acetylcholine receptor M5 (CHRM5) DM52CPU MT DTT DM52CPU MA Inhibitor DM52CPU RN Chloro-substituted, sterically hindered 5,11-dicarbo analogues of clozapine as potential chiral antipsychotic agents. J Med Chem. 1990 Feb;33(2):809-14. DM52CPU RU https://pubmed.ncbi.nlm.nih.gov/1967652 DMMF1HX DI DMMF1HX DMMF1HX DN ISOCONAZOLE DMMF1HX MI TTRA5BZ DMMF1HX MN Steroid 17-alpha-monooxygenase (S17AH) DMMF1HX MT DTT DMMF1HX MA Inhibitor DMMF1HX RN Three dimensional pharmacophore modeling of human CYP17 inhibitors. Potential agents for prostate cancer therapy. J Med Chem. 2003 Jun 5;46(12):2345-51. DMMF1HX RU https://pubmed.ncbi.nlm.nih.gov/12773039 DM7ZSVD DI DM7ZSVD DM7ZSVD DN ISODISPAR B DM7ZSVD MI TT84ETX DM7ZSVD MN Human immunodeficiency virus Reverse transcriptase (HIV RT) DM7ZSVD MT DTT DM7ZSVD MA Inhibitor DM7ZSVD RN 4-Phenylcoumarins as HIV transcription inhibitors. Bioorg Med Chem Lett. 2005 Oct 15;15(20):4447-50. DM7ZSVD RU https://pubmed.ncbi.nlm.nih.gov/16137881 DMSLO71 DI DMSLO71 DMSLO71 DN Isoelaeocarpine DMSLO71 MI TT27RFC DMSLO71 MN Opioid receptor delta (OPRD1) DMSLO71 MT DTT DMSLO71 MA Inhibitor DMSLO71 RN Indolizidine alkaloids with delta-opioid receptor binding affinity from the leaves of Elaeocarpus fuscoides. J Nat Prod. 2007 May;70(5):872-5. DMSLO71 RU https://pubmed.ncbi.nlm.nih.gov/17451272 DMN23KT DI DMN23KT DMN23KT DN isoferulic acid DMN23KT MI TTXMI0C DMN23KT MN Phosphomevalonate kinase (PMVK) DMN23KT MT DTT DMN23KT MA Inhibitor DMN23KT RN Inhibition of rat liver mevalonate pyrophosphate decarboxylase and mevalonate phosphate kinase by phenyl and phenolic compounds. Biochem J. 1979 Jul 1;181(1):143-51. DMN23KT RU https://pubmed.ncbi.nlm.nih.gov/226078 DM5CMA8 DI DM5CMA8 DM5CMA8 DN ISOFORMONENTIN DM5CMA8 MI TTFLN4T DM5CMA8 MN Mitochondrial aldehyde dehydrogenase (ALDH2) DM5CMA8 MT DTT DM5CMA8 MA Inhibitor DM5CMA8 RN Structure of daidzin, a naturally occurring anti-alcohol-addiction agent, in complex with human mitochondrial aldehyde dehydrogenase. J Med Chem. 2008 Aug 14;51(15):4482-7. DM5CMA8 RU https://pubmed.ncbi.nlm.nih.gov/18613661 DM31AXO DI DM31AXO DM31AXO DN Isogemichalcone C DM31AXO MI TTSZLWK DM31AXO MN Aromatase (CYP19A1) DM31AXO MT DTT DM31AXO MA Inhibitor DM31AXO RN Aromatase inhibitors from Broussonetia papyrifera. J Nat Prod. 2001 Oct;64(10):1286-93. DM31AXO RU https://pubmed.ncbi.nlm.nih.gov/11678652 DMCF1ZD DI DMCF1ZD DMCF1ZD DN ISOGOIAZENSOLIDE DMCF1ZD MI TTSXVID DMCF1ZD MN Nuclear factor NF-kappa-B (NFKB) DMCF1ZD MT DTT DMCF1ZD MA Inhibitor DMCF1ZD RN Quantitative structure-activity relationship of sesquiterpene lactones as inhibitors of the transcription factor NF-kappaB. J Med Chem. 2004 Nov 18;47(24):6042-54. DMCF1ZD RU https://pubmed.ncbi.nlm.nih.gov/15537359 DMI6NJ1 DI DMI6NJ1 DMI6NJ1 DN Isogranulatimide DMI6NJ1 MI TTTU902 DMI6NJ1 MN Checkpoint kinase-1 (CHK1) DMI6NJ1 MT DTT DMI6NJ1 MA Inhibitor DMI6NJ1 RN Synthesis, in vitro antiproliferative activities, and Chk1 inhibitory properties of pyrrolo[3,4-a]carbazole-1,3-diones, pyrrolo[3,4-c]carbazole-1,3... Eur J Med Chem. 2008 Feb;43(2):282-92. DMI6NJ1 RU https://pubmed.ncbi.nlm.nih.gov/17502122 DMAFLCJ DI DMAFLCJ DMAFLCJ DN Isoguanosine DMAFLCJ MI TTK25J1 DMAFLCJ MN Adenosine A1 receptor (ADORA1) DMAFLCJ MT DTT DMAFLCJ MA Inhibitor DMAFLCJ RN High selectivity of novel isoguanosine analogues for the adenosine A1 receptor. Bioorg. Med. Chem. Lett. 1(9):481-486 (1991). DMAFLCJ RU http://www.sciencedirect.com/science/article/pii/S0960894X01811100 DMAFLCJ DI DMAFLCJ DMAFLCJ DN Isoguanosine DMAFLCJ MI TTM2AOE DMAFLCJ MN Adenosine A2a receptor (ADORA2A) DMAFLCJ MT DTT DMAFLCJ MA Inhibitor DMAFLCJ RN High selectivity of novel isoguanosine analogues for the adenosine A1 receptor. Bioorg. Med. Chem. Lett. 1(9):481-486 (1991). DMAFLCJ RU http://www.sciencedirect.com/science/article/pii/S0960894X01811100 DMAFLCJ DI DMAFLCJ DMAFLCJ DN Isoguanosine DMAFLCJ MI TTNE7KG DMAFLCJ MN Adenosine A2b receptor (ADORA2B) DMAFLCJ MT DTT DMAFLCJ MA Inhibitor DMAFLCJ RN High selectivity of novel isoguanosine analogues for the adenosine A1 receptor. Bioorg. Med. Chem. Lett. 1(9):481-486 (1991). DMAFLCJ RU http://www.sciencedirect.com/science/article/pii/S0960894X01811100 DMZH9PW DI DMZH9PW DMZH9PW DN Isohelenin DMZH9PW MI TTSXVID DMZH9PW MN Nuclear factor NF-kappa-B (NFKB) DMZH9PW MT DTT DMZH9PW MA Inhibitor DMZH9PW RN Protective effects of isohelenin, an inhibitor of nuclear factor kappaB, in endotoxic shock in rats. J Endotoxin Res. 2002;8(2):99-107. DMZH9PW RU https://pubmed.ncbi.nlm.nih.gov/12028749 DMQC4HV DI DMQC4HV DMQC4HV DN Isoindolinone Urea derivative DMQC4HV MI TTUTJGQ DMQC4HV MN Vascular endothelial growth factor receptor 2 (KDR) DMQC4HV MT DTT DMQC4HV MA Inhibitor DMQC4HV RN Isoindolinone ureas: a novel class of KDR kinase inhibitors. Bioorg Med Chem Lett. 2004 Sep 6;14(17):4505-9. DMQC4HV RU https://pubmed.ncbi.nlm.nih.gov/15357981 DMHTBDN DI DMHTBDN DMHTBDN DN Isojaspic acid DMHTBDN MI TT12ABZ DMHTBDN MN Arachidonate 12-lipoxygenase (12-LOX) DMHTBDN MT DTT DMHTBDN MA Inhibitor DMHTBDN RN Using enzyme assays to evaluate the structure and bioactivity of sponge-derived meroterpenes. J Nat Prod. 2009 Oct;72(10):1857-63. DMHTBDN RU https://pubmed.ncbi.nlm.nih.gov/19848434 DMHTBDN DI DMHTBDN DMHTBDN DN Isojaspic acid DMHTBDN MI TTN9T81 DMHTBDN MN Arachidonate 15-lipoxygenase (15-LOX) DMHTBDN MT DTT DMHTBDN MA Inhibitor DMHTBDN RN Using enzyme assays to evaluate the structure and bioactivity of sponge-derived meroterpenes. J Nat Prod. 2009 Oct;72(10):1857-63. DMHTBDN RU https://pubmed.ncbi.nlm.nih.gov/19848434 DMHTBDN DI DMHTBDN DMHTBDN DN Isojaspic acid DMHTBDN MI TTSJ6Q4 DMHTBDN MN LOX-5 messenger RNA (ALOX5 mRNA) DMHTBDN MT DTT DMHTBDN MA Inhibitor DMHTBDN RN Using enzyme assays to evaluate the structure and bioactivity of sponge-derived meroterpenes. J Nat Prod. 2009 Oct;72(10):1857-63. DMHTBDN RU https://pubmed.ncbi.nlm.nih.gov/19848434 DMYEGBC DI DMYEGBC DMYEGBC DN ISOLICOFLAVONOL DMYEGBC MI TTSZLWK DMYEGBC MN Aromatase (CYP19A1) DMYEGBC MT DTT DMYEGBC MA Inhibitor DMYEGBC RN Aromatase inhibitors from Broussonetia papyrifera. J Nat Prod. 2001 Oct;64(10):1286-93. DMYEGBC RU https://pubmed.ncbi.nlm.nih.gov/11678652 DMXWOBE DI DMXWOBE DMXWOBE DN ISOLONGIFOLOL DMXWOBE MI TTO69J7 DMXWOBE MN UDP-glucuronosyltransferase 2B7 (UGT2B7) DMXWOBE MT DTT DMXWOBE MA Inhibitor DMXWOBE RN Isoform-selective inhibition of the human UDP-glucuronosyltransferase 2B7 by isolongifolol derivatives. J Med Chem. 2007 May 31;50(11):2655-64. DMXWOBE RU https://pubmed.ncbi.nlm.nih.gov/17474732 DMH1BN4 DI DMH1BN4 DMH1BN4 DN ISOLOXAPINE DMH1BN4 MI TTZFYLI DMH1BN4 MN Dopamine D1 receptor (D1R) DMH1BN4 MT DTT DMH1BN4 MA Inhibitor DMH1BN4 RN Synthesis of clozapine analogues and their affinity for clozapine and spiroperidol binding sites in rat brain. J Med Chem. 1981 Sep;24(9):1021-6. DMH1BN4 RU https://pubmed.ncbi.nlm.nih.gov/7288815 DMH1BN4 DI DMH1BN4 DMH1BN4 DN ISOLOXAPINE DMH1BN4 MI TTEX248 DMH1BN4 MN Dopamine D2 receptor (D2R) DMH1BN4 MT DTT DMH1BN4 MA Inhibitor DMH1BN4 RN Synthesis of clozapine analogues and their affinity for clozapine and spiroperidol binding sites in rat brain. J Med Chem. 1981 Sep;24(9):1021-6. DMH1BN4 RU https://pubmed.ncbi.nlm.nih.gov/7288815 DMH1BN4 DI DMH1BN4 DMH1BN4 DN ISOLOXAPINE DMH1BN4 MI TT4C8EA DMH1BN4 MN Dopamine D3 receptor (D3R) DMH1BN4 MT DTT DMH1BN4 MA Inhibitor DMH1BN4 RN Synthesis of clozapine analogues and their affinity for clozapine and spiroperidol binding sites in rat brain. J Med Chem. 1981 Sep;24(9):1021-6. DMH1BN4 RU https://pubmed.ncbi.nlm.nih.gov/7288815 DMH1BN4 DI DMH1BN4 DMH1BN4 DN ISOLOXAPINE DMH1BN4 MI TTE0A2F DMH1BN4 MN Dopamine D4 receptor (D4R) DMH1BN4 MT DTT DMH1BN4 MA Inhibitor DMH1BN4 RN Synthesis of clozapine analogues and their affinity for clozapine and spiroperidol binding sites in rat brain. J Med Chem. 1981 Sep;24(9):1021-6. DMH1BN4 RU https://pubmed.ncbi.nlm.nih.gov/7288815 DMH1BN4 DI DMH1BN4 DMH1BN4 DN ISOLOXAPINE DMH1BN4 MI TTS2PH3 DMH1BN4 MN Dopamine D5 receptor (D5R) DMH1BN4 MT DTT DMH1BN4 MA Inhibitor DMH1BN4 RN Synthesis of clozapine analogues and their affinity for clozapine and spiroperidol binding sites in rat brain. J Med Chem. 1981 Sep;24(9):1021-6. DMH1BN4 RU https://pubmed.ncbi.nlm.nih.gov/7288815 DMH1BN4 DI DMH1BN4 DMH1BN4 DN ISOLOXAPINE DMH1BN4 MI TTZ9SOR DMH1BN4 MN Muscarinic acetylcholine receptor M1 (CHRM1) DMH1BN4 MT DTT DMH1BN4 MA Inhibitor DMH1BN4 RN Synthesis of clozapine analogues and their affinity for clozapine and spiroperidol binding sites in rat brain. J Med Chem. 1981 Sep;24(9):1021-6. DMH1BN4 RU https://pubmed.ncbi.nlm.nih.gov/7288815 DMH1BN4 DI DMH1BN4 DMH1BN4 DN ISOLOXAPINE DMH1BN4 MI TTYEG6Q DMH1BN4 MN Muscarinic acetylcholine receptor M2 (CHRM2) DMH1BN4 MT DTT DMH1BN4 MA Inhibitor DMH1BN4 RN Synthesis of clozapine analogues and their affinity for clozapine and spiroperidol binding sites in rat brain. J Med Chem. 1981 Sep;24(9):1021-6. DMH1BN4 RU https://pubmed.ncbi.nlm.nih.gov/7288815 DMH1BN4 DI DMH1BN4 DMH1BN4 DN ISOLOXAPINE DMH1BN4 MI TTQ13Z5 DMH1BN4 MN Muscarinic acetylcholine receptor M3 (CHRM3) DMH1BN4 MT DTT DMH1BN4 MA Inhibitor DMH1BN4 RN Synthesis of clozapine analogues and their affinity for clozapine and spiroperidol binding sites in rat brain. J Med Chem. 1981 Sep;24(9):1021-6. DMH1BN4 RU https://pubmed.ncbi.nlm.nih.gov/7288815 DMH1BN4 DI DMH1BN4 DMH1BN4 DN ISOLOXAPINE DMH1BN4 MI TTQ3JTF DMH1BN4 MN Muscarinic acetylcholine receptor M4 (CHRM4) DMH1BN4 MT DTT DMH1BN4 MA Inhibitor DMH1BN4 RN Synthesis of clozapine analogues and their affinity for clozapine and spiroperidol binding sites in rat brain. J Med Chem. 1981 Sep;24(9):1021-6. DMH1BN4 RU https://pubmed.ncbi.nlm.nih.gov/7288815 DMH1BN4 DI DMH1BN4 DMH1BN4 DN ISOLOXAPINE DMH1BN4 MI TTH18TF DMH1BN4 MN Muscarinic acetylcholine receptor M5 (CHRM5) DMH1BN4 MT DTT DMH1BN4 MA Inhibitor DMH1BN4 RN Synthesis of clozapine analogues and their affinity for clozapine and spiroperidol binding sites in rat brain. J Med Chem. 1981 Sep;24(9):1021-6. DMH1BN4 RU https://pubmed.ncbi.nlm.nih.gov/7288815 DMD1KSW DI DMD1KSW DMD1KSW DN Isomaltose DMD1KSW MI DEST6E5 DMD1KSW MN Alpha-glucosidase (aglA) DMD1KSW MT DME DMD1KSW MA Metabolism DMD1KSW RN Novel alpha-glucosidase from human gut microbiome: substrate specificities and their switch. FASEB J. 2010 Oct;24(10):3939-49. DMD1KSW RU https://pubmed.ncbi.nlm.nih.gov/20581222 DMOJ52F DI DMOJ52F DMOJ52F DN ISOMER A DMOJ52F MI TTY6O0Q DMOJ52F MN Calcitonin gene-related peptide receptor (CGRPR) DMOJ52F MT DTT DMOJ52F MA Inhibitor DMOJ52F RN The identification of potent, orally bioavailable tricyclic CGRP receptor antagonists. Bioorg Med Chem Lett. 2009 Aug 15;19(16):4740-2. DMOJ52F RU https://pubmed.ncbi.nlm.nih.gov/19577468 DM69XT3 DI DM69XT3 DM69XT3 DN ISONEORAUTENOL DM69XT3 MI TT50QJ3 DM69XT3 MN Influenza Neuraminidase (Influ NA) DM69XT3 MT DTT DM69XT3 MA Inhibitor DM69XT3 RN Prenylated pterocarpans as bacterial neuraminidase inhibitors. Bioorg Med Chem. 2010 May 1;18(9):3335-44. DM69XT3 RU https://pubmed.ncbi.nlm.nih.gov/20363636 DMUVAIF DI DMUVAIF DMUVAIF DN ISONICOTINIC ACID DMUVAIF MI TTWNV8U DMUVAIF MN Nicotinic acid receptor (HCAR2) DMUVAIF MT DTT DMUVAIF MA Inhibitor DMUVAIF RN Pyrazole derivatives as partial agonists for the nicotinic acid receptor. J Med Chem. 2003 Aug 28;46(18):3945-51. DMUVAIF RU https://pubmed.ncbi.nlm.nih.gov/12930155 DM5DKUY DI DM5DKUY DM5DKUY DN ISONIPECOTAMIDE DM5DKUY MI TTT1R2L DM5DKUY MN Integrin alpha-V (ITGAV) DM5DKUY MT DTT DM5DKUY MA Inhibitor DM5DKUY RN Piperidine-containing beta-arylpropionic acids as potent antagonists of alphavbeta3/alphavbeta5 integrins. Bioorg Med Chem Lett. 2004 Oct 18;14(20):5227-32. DM5DKUY RU https://pubmed.ncbi.nlm.nih.gov/15380233 DM5DKUY DI DM5DKUY DM5DKUY DN ISONIPECOTAMIDE DM5DKUY MI TTJA1ZO DM5DKUY MN ITGB3 messenger RNA (ITGB3 mRNA) DM5DKUY MT DTT DM5DKUY MA Inhibitor DM5DKUY RN Piperidine-containing beta-arylpropionic acids as potent antagonists of alphavbeta3/alphavbeta5 integrins. Bioorg Med Chem Lett. 2004 Oct 18;14(20):5227-32. DM5DKUY RU https://pubmed.ncbi.nlm.nih.gov/15380233 DMO1ZHE DI DMO1ZHE DMO1ZHE DN Isonipecotic acid DMO1ZHE MI TTBMV1G DMO1ZHE MN GABA(A) receptor alpha-2 (GABRA2) DMO1ZHE MT DTT DMO1ZHE MA Agonist DMO1ZHE RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 405). DMO1ZHE RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=405 DMO1ZHE DI DMO1ZHE DMO1ZHE DN Isonipecotic acid DMO1ZHE MI TT37EDJ DMO1ZHE MN GABA(A) receptor alpha-3 (GABRA3) DMO1ZHE MT DTT DMO1ZHE MA Agonist DMO1ZHE RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 406). DMO1ZHE RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=406 DMO1ZHE DI DMO1ZHE DMO1ZHE DN Isonipecotic acid DMO1ZHE MI TTNZPQ1 DMO1ZHE MN GABA(A) receptor alpha-5 (GABRA5) DMO1ZHE MT DTT DMO1ZHE MA Agonist DMO1ZHE RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 408). DMO1ZHE RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=408 DMO1ZHE DI DMO1ZHE DMO1ZHE DN Isonipecotic acid DMO1ZHE MI TTEX6LM DMO1ZHE MN GABA(A) receptor gamma-3 (GABRG3) DMO1ZHE MT DTT DMO1ZHE MA Agonist DMO1ZHE RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 415). DMO1ZHE RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=415 DMO1ZHE DI DMO1ZHE DMO1ZHE DN Isonipecotic acid DMO1ZHE MI TT6XFEU DMO1ZHE MN GABA(A) receptor rho1 (GABRR1) DMO1ZHE MT DTT DMO1ZHE MA Antagonist DMO1ZHE RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 420). DMO1ZHE RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=420 DMO1ZHE DI DMO1ZHE DMO1ZHE DN Isonipecotic acid DMO1ZHE MI TTQMXLS DMO1ZHE MN GABA(A) receptor rho2 (GABRR2) DMO1ZHE MT DTT DMO1ZHE MA Antagonist DMO1ZHE RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 421). DMO1ZHE RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=421 DMO1ZHE DI DMO1ZHE DMO1ZHE DN Isonipecotic acid DMO1ZHE MI TT4N6D8 DMO1ZHE MN GABA(A) receptor rho3 (GABRR3) DMO1ZHE MT DTT DMO1ZHE MA Antagonist DMO1ZHE RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 422). DMO1ZHE RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=422 DMO1ZHE DI DMO1ZHE DMO1ZHE DN Isonipecotic acid DMO1ZHE MI TTNJYV2 DMO1ZHE MN Gamma-aminobutyric acid receptor (GAR) DMO1ZHE MT DTT DMO1ZHE MA Inhibitor DMO1ZHE RN Hydroxy- and amino-substituted piperidinecarboxylic acids as gamma-aminobutyric acid agonists and uptake inhibitors. J Med Chem. 1982 Oct;25(10):1157-62. DMO1ZHE RU https://pubmed.ncbi.nlm.nih.gov/6292417 DMFX16H DI DMFX16H DMFX16H DN Iso-OMPA DMFX16H MI TT1RS9F DMFX16H MN Acetylcholinesterase (AChE) DMFX16H MT DTT DMFX16H MA Inhibitor DMFX16H RN Isosorbide-2-carbamate esters: potent and selective butyrylcholinesterase inhibitors. J Med Chem. 2008 Oct 23;51(20):6400-9. DMFX16H RU https://pubmed.ncbi.nlm.nih.gov/18817366 DMFX16H DI DMFX16H DMFX16H DN Iso-OMPA DMFX16H MI TTEB0GD DMFX16H MN Cholinesterase (BCHE) DMFX16H MT DTT DMFX16H MA Inhibitor DMFX16H RN Isosorbide-2-carbamate esters: potent and selective butyrylcholinesterase inhibitors. J Med Chem. 2008 Oct 23;51(20):6400-9. DMFX16H RU https://pubmed.ncbi.nlm.nih.gov/18817366 DMTU05Y DI DMTU05Y DMTU05Y DN ISOPENTENYL PYROPHOSPHATE DMTU05Y MI TT5VER7 DMTU05Y MN Bacterial Undecaprenyl pyrophosphate synthetase (Bact ispU) DMTU05Y MT DTT DMTU05Y MA Inhibitor DMTU05Y RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DMTU05Y RU https://pubmed.ncbi.nlm.nih.gov/10592235 DMTU05Y DI DMTU05Y DMTU05Y DN ISOPENTENYL PYROPHOSPHATE DMTU05Y MI TTIKWV4 DMTU05Y MN Geranyltranstransferase (FDPS) DMTU05Y MT DTT DMTU05Y MA Inhibitor DMTU05Y RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DMTU05Y RU https://pubmed.ncbi.nlm.nih.gov/10592235 DM9J5IS DI DM9J5IS DM9J5IS DN Isopentyl Pyrophosphate DM9J5IS MI TTIKWV4 DM9J5IS MN Geranyltranstransferase (FDPS) DM9J5IS MT DTT DM9J5IS MA Inhibitor DM9J5IS RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DM9J5IS RU https://pubmed.ncbi.nlm.nih.gov/17139284 DM9ERD6 DI DM9ERD6 DM9ERD6 DN ISOPILINE DM9ERD6 MI TTVBI8W DM9ERD6 MN Dopamine transporter (DAT) DM9ERD6 MT DTT DM9ERD6 MA Inhibitor DM9ERD6 RN Effects of various isoquinoline alkaloids on in vitro 3H-dopamine uptake by rat striatal synaptosomes. J Nat Prod. 1995 Oct;58(10):1475-84. DM9ERD6 RU https://pubmed.ncbi.nlm.nih.gov/8676127 DMWI0M8 DI DMWI0M8 DMWI0M8 DN ISOPPADS DMWI0M8 MI TT2THBD DMWI0M8 MN P2X purinoceptor 3 (P2RX3) DMWI0M8 MT DTT DMWI0M8 MA Inhibitor DMWI0M8 RN Structure-activity relationships of pyridoxal phosphate derivatives as potent and selective antagonists of P2X1 receptors. J Med Chem. 2001 Feb 1;44(3):340-9. DMWI0M8 RU https://pubmed.ncbi.nlm.nih.gov/11462975 DMWI0M8 DI DMWI0M8 DMWI0M8 DN ISOPPADS DMWI0M8 MI TT473XN DMWI0M8 MN P2X purinoceptor 7 (P2RX7) DMWI0M8 MT DTT DMWI0M8 MA Inhibitor DMWI0M8 RN Structure-activity relationship studies of spinorphin as a potent and selective human P2X(3) receptor antagonist. J Med Chem. 2007 Sep 6;50(18):4543-7. DMWI0M8 RU https://pubmed.ncbi.nlm.nih.gov/17676725 DMH67J2 DI DMH67J2 DMH67J2 DN Isopropyl 10H-phenothiazine-10-carboxylate DMH67J2 MI TTEB0GD DMH67J2 MN Cholinesterase (BCHE) DMH67J2 MT DTT DMH67J2 MA Inhibitor DMH67J2 RN Carbamates with differential mechanism of inhibition toward acetylcholinesterase and butyrylcholinesterase. J Med Chem. 2008 Jul 24;51(14):4200-12. DMH67J2 RU https://pubmed.ncbi.nlm.nih.gov/18570368 DMS8MBI DI DMS8MBI DMS8MBI DN Isopropyl 3-(phenylthio)-1H-indole-2-carboxylate DMS8MBI MI TTML2WA DMS8MBI MN Tubulin (TUB) DMS8MBI MT DTT DMS8MBI MA Inhibitor DMS8MBI RN New arylthioindoles: potent inhibitors of tubulin polymerization. 2. Structure-activity relationships and molecular modeling studies. J Med Chem. 2006 Feb 9;49(3):947-54. DMS8MBI RU https://pubmed.ncbi.nlm.nih.gov/16451061 DMS8MBI DI DMS8MBI DMS8MBI DN Isopropyl 3-(phenylthio)-1H-indole-2-carboxylate DMS8MBI MI TTYFKSZ DMS8MBI MN Tubulin beta (TUBB) DMS8MBI MT DTT DMS8MBI MA Inhibitor DMS8MBI RN New arylthioindoles: potent inhibitors of tubulin polymerization. 2. Structure-activity relationships and molecular modeling studies. J Med Chem. 2006 Feb 9;49(3):947-54. DMS8MBI RU https://pubmed.ncbi.nlm.nih.gov/16451061 DM2VJF4 DI DM2VJF4 DM2VJF4 DN Isopropyl 4-nitrophenyl dodecylphosphonate DM2VJF4 MI TT6OEDT DM2VJF4 MN Cannabinoid receptor 1 (CB1) DM2VJF4 MT DTT DM2VJF4 MA Inhibitor DM2VJF4 RN Monoacylglycerol lipase regulates 2-arachidonoylglycerol action and arachidonic acid levels. Bioorg Med Chem Lett. 2008 Nov 15;18(22):5875-8. DM2VJF4 RU https://pubmed.ncbi.nlm.nih.gov/18752948 DM2VJF4 DI DM2VJF4 DM2VJF4 DN Isopropyl 4-nitrophenyl dodecylphosphonate DM2VJF4 MI TTDP1UC DM2VJF4 MN Fatty acid amide hydrolase (FAAH) DM2VJF4 MT DTT DM2VJF4 MA Inhibitor DM2VJF4 RN Monoacylglycerol lipase regulates 2-arachidonoylglycerol action and arachidonic acid levels. Bioorg Med Chem Lett. 2008 Nov 15;18(22):5875-8. DM2VJF4 RU https://pubmed.ncbi.nlm.nih.gov/18752948 DML54EA DI DML54EA DML54EA DN Isopropyl dodecylfluorophosphonate DML54EA MI TT1RS9F DML54EA MN Acetylcholinesterase (AChE) DML54EA MT DTT DML54EA MA Inhibitor DML54EA RN Activation of the endocannabinoid system by organophosphorus nerve agents. Nat Chem Biol. 2008 Jun;4(6):373-8. DML54EA RU https://pubmed.ncbi.nlm.nih.gov/18438404 DML54EA DI DML54EA DML54EA DN Isopropyl dodecylfluorophosphonate DML54EA MI TT6OEDT DML54EA MN Cannabinoid receptor 1 (CB1) DML54EA MT DTT DML54EA MA Inhibitor DML54EA RN Activation of the endocannabinoid system by organophosphorus nerve agents. Nat Chem Biol. 2008 Jun;4(6):373-8. DML54EA RU https://pubmed.ncbi.nlm.nih.gov/18438404 DML54EA DI DML54EA DML54EA DN Isopropyl dodecylfluorophosphonate DML54EA MI TTDP1UC DML54EA MN Fatty acid amide hydrolase (FAAH) DML54EA MT DTT DML54EA MA Inhibitor DML54EA RN Activation of the endocannabinoid system by organophosphorus nerve agents. Nat Chem Biol. 2008 Jun;4(6):373-8. DML54EA RU https://pubmed.ncbi.nlm.nih.gov/18438404 DMBR8P1 DI DMBR8P1 DMBR8P1 DN Isopropylcarbamic Acid Biphenyl-3-yl Ester DMBR8P1 MI TTDP1UC DMBR8P1 MN Fatty acid amide hydrolase (FAAH) DMBR8P1 MT DTT DMBR8P1 MA Inhibitor DMBR8P1 RN Synthesis and quantitative structure-activity relationship of fatty acid amide hydrolase inhibitors: modulation at the N-portion of biphenyl-3-yl a... J Med Chem. 2008 Jun 26;51(12):3487-98. DMBR8P1 RU https://pubmed.ncbi.nlm.nih.gov/18507372 DM92F6Z DI DM92F6Z DM92F6Z DN Isopropyl-methyl-prop-2-ynyl-amine hydrochloride DM92F6Z MI TTGP7BY DM92F6Z MN Monoamine oxidase type B (MAO-B) DM92F6Z MT DTT DM92F6Z MA Inhibitor DM92F6Z RN Aliphatic propargylamines: potent, selective, irreversible monoamine oxidase B inhibitors. J Med Chem. 1992 Oct 2;35(20):3705-13. DM92F6Z RU https://pubmed.ncbi.nlm.nih.gov/1433183 DMPYAMU DI DMPYAMU DMPYAMU DN isopulegol DMPYAMU MI TTXDKTO DMPYAMU MN Long transient receptor potential channel 8 (TRPM8) DMPYAMU MT DTT DMPYAMU MA Activator DMPYAMU RN Characterization of the mouse cold-menthol receptor TRPM8 and vanilloid receptor type-1 VR1 using a fluorometric imaging plate reader (FLIPR) assay. Br J Pharmacol. 2004 Feb;141(4):737-45. DMPYAMU RU https://pubmed.ncbi.nlm.nih.gov/14757700 DMDF26N DI DMDF26N DMDF26N DN Isoquinolin-1-yl-(3-phenyl-propyl)-amine DMDF26N MI TT64EPS DMDF26N MN Fungal Scytalone dehydratase (Fung SDH1) DMDF26N MT DTT DMDF26N MA Inhibitor DMDF26N RN A diazine heterocycle replaces a six-membered hydrogen-bonded array in the active site of scytalone dehydratase, Bioorg. Med. Chem. Lett. 3(8):1605-1608 (1993). DMDF26N RU http://www.sciencedirect.com/science/article/pii/S0960894X00800268 DMT4RI2 DI DMT4RI2 DMT4RI2 DN Isoquinoline-1,3,4(2H)-trione DMT4RI2 MI TTZY5KP DMT4RI2 MN Caspase (CASP) DMT4RI2 MT DTT DMT4RI2 MA Inhibitor DMT4RI2 RN Design, synthesis, and biological evaluation of isoquinoline-1,3,4-trione derivatives as potent caspase-3 inhibitors. J Med Chem. 2006 Mar 9;49(5):1613-23. DMT4RI2 RU https://pubmed.ncbi.nlm.nih.gov/16509578 DMT4RI2 DI DMT4RI2 DMT4RI2 DN Isoquinoline-1,3,4(2H)-trione DMT4RI2 MI TTKW4ML DMT4RI2 MN Caspase 6 messenger RNA (CASP6 mRNA) DMT4RI2 MT DTT DMT4RI2 MA Inhibitor DMT4RI2 RN Design, synthesis, and biological evaluation of isoquinoline-1,3,4-trione derivatives as potent caspase-3 inhibitors. J Med Chem. 2006 Mar 9;49(5):1613-23. DMT4RI2 RU https://pubmed.ncbi.nlm.nih.gov/16509578 DMT4RI2 DI DMT4RI2 DMT4RI2 DN Isoquinoline-1,3,4(2H)-trione DMT4RI2 MI TT6SZNG DMT4RI2 MN Caspase 8 messenger RNA (CASP8 mRNA) DMT4RI2 MT DTT DMT4RI2 MA Inhibitor DMT4RI2 RN Design, synthesis, and biological evaluation of isoquinoline-1,3,4-trione derivatives as potent caspase-3 inhibitors. J Med Chem. 2006 Mar 9;49(5):1613-23. DMT4RI2 RU https://pubmed.ncbi.nlm.nih.gov/16509578 DMT4RI2 DI DMT4RI2 DMT4RI2 DN Isoquinoline-1,3,4(2H)-trione DMT4RI2 MI TTPF2QI DMT4RI2 MN Caspase-3 (CASP3) DMT4RI2 MT DTT DMT4RI2 MA Inhibitor DMT4RI2 RN Design, synthesis, and biological evaluation of isoquinoline-1,3,4-trione derivatives as potent caspase-3 inhibitors. J Med Chem. 2006 Mar 9;49(5):1613-23. DMT4RI2 RU https://pubmed.ncbi.nlm.nih.gov/16509578 DMWIMUZ DI DMWIMUZ DMWIMUZ DN Isoquinoline-3-carboxylic acid methyl ester DMWIMUZ MI TT1MPAY DMWIMUZ MN GABA(A) receptor alpha-1 (GABRA1) DMWIMUZ MT DTT DMWIMUZ MA Inhibitor DMWIMUZ RN Synthesis of novel 3-substituted beta-carbolines as benzodiazepine receptor ligands: probing the benzodiazepine receptor pharmacophore. J Med Chem. 1988 Sep;31(9):1854-61. DMWIMUZ RU https://pubmed.ncbi.nlm.nih.gov/2842507 DMWIMUZ DI DMWIMUZ DMWIMUZ DN Isoquinoline-3-carboxylic acid methyl ester DMWIMUZ MI TTNJYV2 DMWIMUZ MN Gamma-aminobutyric acid receptor (GAR) DMWIMUZ MT DTT DMWIMUZ MA Inhibitor DMWIMUZ RN Synthesis of novel 3-substituted beta-carbolines as benzodiazepine receptor ligands: probing the benzodiazepine receptor pharmacophore. J Med Chem. 1988 Sep;31(9):1854-61. DMWIMUZ RU https://pubmed.ncbi.nlm.nih.gov/2842507 DMQ4Z6E DI DMQ4Z6E DMQ4Z6E DN ISORHAMNETIN DMQ4Z6E MI TTI84H7 DMQ4Z6E MN Cytochrome P450 1B1 (CYP1B1) DMQ4Z6E MT DTT DMQ4Z6E MA Inhibitor DMQ4Z6E RN Selective inhibition of methoxyflavonoids on human CYP1B1 activity. Bioorg Med Chem. 2010 Sep 1;18(17):6310-5. DMQ4Z6E RU https://pubmed.ncbi.nlm.nih.gov/20696580 DMQ4Z6E DI DMQ4Z6E DMQ4Z6E DN ISORHAMNETIN DMQ4Z6E MI TTNX2CS DMQ4Z6E MN Plasmodium Enoyl-ACP reductase (Malaria fabI) DMQ4Z6E MT DTT DMQ4Z6E MA Inhibitor DMQ4Z6E RN Inhibition of Plasmodium falciparum fatty acid biosynthesis: evaluation of FabG, FabZ, and FabI as drug targets for flavonoids. J Med Chem. 2006 Jun 1;49(11):3345-53. DMQ4Z6E RU https://pubmed.ncbi.nlm.nih.gov/16722653 DMQ4Z6E DI DMQ4Z6E DMQ4Z6E DN ISORHAMNETIN DMQ4Z6E MI TTBE4IR DMQ4Z6E MN Plasmodium Oxoacyl-[acyl-carrier protein] reductase (Malaria fabG) DMQ4Z6E MT DTT DMQ4Z6E MA Inhibitor DMQ4Z6E RN Inhibition of Plasmodium falciparum fatty acid biosynthesis: evaluation of FabG, FabZ, and FabI as drug targets for flavonoids. J Med Chem. 2006 Jun 1;49(11):3345-53. DMQ4Z6E RU https://pubmed.ncbi.nlm.nih.gov/16722653 DMFKQ0B DI DMFKQ0B DMFKQ0B DN Isorhamnetin 3,7-disulfate DMFKQ0B MI TTFBNVI DMFKQ0B MN Aldose reductase (AKR1B1) DMFKQ0B MT DTT DMFKQ0B MA Inhibitor DMFKQ0B RN Effect of Polygonum hydropiper sulfated flavonoids on lens aldose reductase and related enzymes. J Nat Prod. 1996 Apr;59(4):443-5. DMFKQ0B RU https://pubmed.ncbi.nlm.nih.gov/8699190 DMZQUY4 DI DMZQUY4 DMZQUY4 DN Isorhamnetin 3-O-rhamnoside DMZQUY4 MI TTFBNVI DMZQUY4 MN Aldose reductase (AKR1B1) DMZQUY4 MT DTT DMZQUY4 MA Inhibitor DMZQUY4 RN New flavonol oligoglycosides and polyacylated sucroses with inhibitory effects on aldose reductase and platelet aggregation from the flowers of Pru... J Nat Prod. 2002 Aug;65(8):1151-5. DMZQUY4 RU https://pubmed.ncbi.nlm.nih.gov/12193020 DMJS7MV DI DMJS7MV DMJS7MV DN ISOSAKUTANETIN DMJS7MV MI TTI84H7 DMJS7MV MN Cytochrome P450 1B1 (CYP1B1) DMJS7MV MT DTT DMJS7MV MA Inhibitor DMJS7MV RN Selective inhibition of methoxyflavonoids on human CYP1B1 activity. Bioorg Med Chem. 2010 Sep 1;18(17):6310-5. DMJS7MV RU https://pubmed.ncbi.nlm.nih.gov/20696580 DMNM2SQ DI DMNM2SQ DMNM2SQ DN ISOSCOPOLETIN DMNM2SQ MI TTN9T81 DMNM2SQ MN Arachidonate 15-lipoxygenase (15-LOX) DMNM2SQ MT DTT DMNM2SQ MA Inhibitor DMNM2SQ RN Lipoxygenase inhibitory constituents of the fruits of noni (Morinda citrifolia) collected in Tahiti. J Nat Prod. 2007 May;70(5):859-62. DMNM2SQ RU https://pubmed.ncbi.nlm.nih.gov/17378609 DMTRCSV DI DMTRCSV DMTRCSV DN Isosorbide-2-(benzylcarbamate)-5-benzoate DMTRCSV MI TTEB0GD DMTRCSV MN Cholinesterase (BCHE) DMTRCSV MT DTT DMTRCSV MA Inhibitor DMTRCSV RN Isosorbide-2-carbamate esters: potent and selective butyrylcholinesterase inhibitors. J Med Chem. 2008 Oct 23;51(20):6400-9. DMTRCSV RU https://pubmed.ncbi.nlm.nih.gov/18817366 DMG0TW2 DI DMG0TW2 DMG0TW2 DN Isosorbide-2-(benzylcarbamate)-5-mononitrate DMG0TW2 MI TTEB0GD DMG0TW2 MN Cholinesterase (BCHE) DMG0TW2 MT DTT DMG0TW2 MA Inhibitor DMG0TW2 RN Isosorbide-2-carbamate esters: potent and selective butyrylcholinesterase inhibitors. J Med Chem. 2008 Oct 23;51(20):6400-9. DMG0TW2 RU https://pubmed.ncbi.nlm.nih.gov/18817366 DM1ZH2U DI DM1ZH2U DM1ZH2U DN Isosorbide-2-(butylcarbamate)-5-benzoate DM1ZH2U MI TTEB0GD DM1ZH2U MN Cholinesterase (BCHE) DM1ZH2U MT DTT DM1ZH2U MA Inhibitor DM1ZH2U RN Isosorbide-2-carbamate esters: potent and selective butyrylcholinesterase inhibitors. J Med Chem. 2008 Oct 23;51(20):6400-9. DM1ZH2U RU https://pubmed.ncbi.nlm.nih.gov/18817366 DMUDS12 DI DMUDS12 DMUDS12 DN Isosorbide-2-(butylcarbamate)-5-mononitrate DMUDS12 MI TTEB0GD DMUDS12 MN Cholinesterase (BCHE) DMUDS12 MT DTT DMUDS12 MA Inhibitor DMUDS12 RN Isosorbide-2-carbamate esters: potent and selective butyrylcholinesterase inhibitors. J Med Chem. 2008 Oct 23;51(20):6400-9. DMUDS12 RU https://pubmed.ncbi.nlm.nih.gov/18817366 DM4ZYRP DI DM4ZYRP DM4ZYRP DN Isosorbide-2-(cyclohexylcarbamate)-5-mononitrate DM4ZYRP MI TTEB0GD DM4ZYRP MN Cholinesterase (BCHE) DM4ZYRP MT DTT DM4ZYRP MA Inhibitor DM4ZYRP RN Isosorbide-2-carbamate esters: potent and selective butyrylcholinesterase inhibitors. J Med Chem. 2008 Oct 23;51(20):6400-9. DM4ZYRP RU https://pubmed.ncbi.nlm.nih.gov/18817366 DMMH70I DI DMMH70I DMMH70I DN Isosorbide-2-(ethylcarbamate)-5-mononitrate DMMH70I MI TTEB0GD DMMH70I MN Cholinesterase (BCHE) DMMH70I MT DTT DMMH70I MA Inhibitor DMMH70I RN Isosorbide-2-carbamate esters: potent and selective butyrylcholinesterase inhibitors. J Med Chem. 2008 Oct 23;51(20):6400-9. DMMH70I RU https://pubmed.ncbi.nlm.nih.gov/18817366 DMC7MLN DI DMC7MLN DMC7MLN DN Isosorbide-2-(methylcarbamate)-5-benzoate DMC7MLN MI TT1RS9F DMC7MLN MN Acetylcholinesterase (AChE) DMC7MLN MT DTT DMC7MLN MA Inhibitor DMC7MLN RN Isosorbide-2-carbamate esters: potent and selective butyrylcholinesterase inhibitors. J Med Chem. 2008 Oct 23;51(20):6400-9. DMC7MLN RU https://pubmed.ncbi.nlm.nih.gov/18817366 DMC7MLN DI DMC7MLN DMC7MLN DN Isosorbide-2-(methylcarbamate)-5-benzoate DMC7MLN MI TTEB0GD DMC7MLN MN Cholinesterase (BCHE) DMC7MLN MT DTT DMC7MLN MA Inhibitor DMC7MLN RN Isosorbide-2-carbamate esters: potent and selective butyrylcholinesterase inhibitors. J Med Chem. 2008 Oct 23;51(20):6400-9. DMC7MLN RU https://pubmed.ncbi.nlm.nih.gov/18817366 DMEKMOF DI DMEKMOF DMEKMOF DN Isosorbide-2-(methylcarbamate)-5-mononitrate DMEKMOF MI TT1RS9F DMEKMOF MN Acetylcholinesterase (AChE) DMEKMOF MT DTT DMEKMOF MA Inhibitor DMEKMOF RN Isosorbide-2-carbamate esters: potent and selective butyrylcholinesterase inhibitors. J Med Chem. 2008 Oct 23;51(20):6400-9. DMEKMOF RU https://pubmed.ncbi.nlm.nih.gov/18817366 DMEKMOF DI DMEKMOF DMEKMOF DN Isosorbide-2-(methylcarbamate)-5-mononitrate DMEKMOF MI TTEB0GD DMEKMOF MN Cholinesterase (BCHE) DMEKMOF MT DTT DMEKMOF MA Inhibitor DMEKMOF RN Isosorbide-2-carbamate esters: potent and selective butyrylcholinesterase inhibitors. J Med Chem. 2008 Oct 23;51(20):6400-9. DMEKMOF RU https://pubmed.ncbi.nlm.nih.gov/18817366 DMQAEZP DI DMQAEZP DMQAEZP DN Isosorbide-2-(propylcarbamate)-5-mononitrate DMQAEZP MI TTEB0GD DMQAEZP MN Cholinesterase (BCHE) DMQAEZP MT DTT DMQAEZP MA Inhibitor DMQAEZP RN Isosorbide-2-carbamate esters: potent and selective butyrylcholinesterase inhibitors. J Med Chem. 2008 Oct 23;51(20):6400-9. DMQAEZP RU https://pubmed.ncbi.nlm.nih.gov/18817366 DM6FVDO DI DM6FVDO DM6FVDO DN Isosorbide-2-benzyl carbamate DM6FVDO MI TTEB0GD DM6FVDO MN Cholinesterase (BCHE) DM6FVDO MT DTT DM6FVDO MA Inhibitor DM6FVDO RN Isosorbide-2-benzyl carbamate-5-salicylate, a peripheral anionic site binding subnanomolar selective butyrylcholinesterase inhibitor. J Med Chem. 2010 Feb 11;53(3):1190-9. DM6FVDO RU https://pubmed.ncbi.nlm.nih.gov/20067290 DM5XEZI DI DM5XEZI DM5XEZI DN Isosorbide-2-benzylcarbamate-5-(o-toluate) DM5XEZI MI TTEB0GD DM5XEZI MN Cholinesterase (BCHE) DM5XEZI MT DTT DM5XEZI MA Inhibitor DM5XEZI RN Isosorbide-2-benzyl carbamate-5-salicylate, a peripheral anionic site binding subnanomolar selective butyrylcholinesterase inhibitor. J Med Chem. 2010 Feb 11;53(3):1190-9. DM5XEZI RU https://pubmed.ncbi.nlm.nih.gov/20067290 DMD4WRH DI DMD4WRH DMD4WRH DN Isosorbide-2-benzylcarbamate-5-acetate DMD4WRH MI TTEB0GD DMD4WRH MN Cholinesterase (BCHE) DMD4WRH MT DTT DMD4WRH MA Inhibitor DMD4WRH RN Isosorbide-2-carbamate esters: potent and selective butyrylcholinesterase inhibitors. J Med Chem. 2008 Oct 23;51(20):6400-9. DMD4WRH RU https://pubmed.ncbi.nlm.nih.gov/18817366 DMWDQ90 DI DMWDQ90 DMWDQ90 DN Isosorbide-2-benzylcarbamate-5-cyclopentanoate DMWDQ90 MI TT1RS9F DMWDQ90 MN Acetylcholinesterase (AChE) DMWDQ90 MT DTT DMWDQ90 MA Inhibitor DMWDQ90 RN Isosorbide-2-carbamate esters: potent and selective butyrylcholinesterase inhibitors. J Med Chem. 2008 Oct 23;51(20):6400-9. DMWDQ90 RU https://pubmed.ncbi.nlm.nih.gov/18817366 DMWDQ90 DI DMWDQ90 DMWDQ90 DN Isosorbide-2-benzylcarbamate-5-cyclopentanoate DMWDQ90 MI TTEB0GD DMWDQ90 MN Cholinesterase (BCHE) DMWDQ90 MT DTT DMWDQ90 MA Inhibitor DMWDQ90 RN Isosorbide-2-carbamate esters: potent and selective butyrylcholinesterase inhibitors. J Med Chem. 2008 Oct 23;51(20):6400-9. DMWDQ90 RU https://pubmed.ncbi.nlm.nih.gov/18817366 DM8E2L6 DI DM8E2L6 DM8E2L6 DN Isosorbide-2-benzylcarbamate-5-cyclopropanoate DM8E2L6 MI TT1RS9F DM8E2L6 MN Acetylcholinesterase (AChE) DM8E2L6 MT DTT DM8E2L6 MA Inhibitor DM8E2L6 RN Isosorbide-2-carbamate esters: potent and selective butyrylcholinesterase inhibitors. J Med Chem. 2008 Oct 23;51(20):6400-9. DM8E2L6 RU https://pubmed.ncbi.nlm.nih.gov/18817366 DM8E2L6 DI DM8E2L6 DM8E2L6 DN Isosorbide-2-benzylcarbamate-5-cyclopropanoate DM8E2L6 MI TTEB0GD DM8E2L6 MN Cholinesterase (BCHE) DM8E2L6 MT DTT DM8E2L6 MA Inhibitor DM8E2L6 RN Isosorbide-2-carbamate esters: potent and selective butyrylcholinesterase inhibitors. J Med Chem. 2008 Oct 23;51(20):6400-9. DM8E2L6 RU https://pubmed.ncbi.nlm.nih.gov/18817366 DMQ3Z17 DI DMQ3Z17 DMQ3Z17 DN Isosorbide-2-benzylcarbamate-5-isonicotinate DMQ3Z17 MI TTEB0GD DMQ3Z17 MN Cholinesterase (BCHE) DMQ3Z17 MT DTT DMQ3Z17 MA Inhibitor DMQ3Z17 RN Isosorbide-2-carbamate esters: potent and selective butyrylcholinesterase inhibitors. J Med Chem. 2008 Oct 23;51(20):6400-9. DMQ3Z17 RU https://pubmed.ncbi.nlm.nih.gov/18817366 DMY49DN DI DMY49DN DMY49DN DN Isosorbide-2-benzylcarbamate-5-nicotinate DMY49DN MI TTEB0GD DMY49DN MN Cholinesterase (BCHE) DMY49DN MT DTT DMY49DN MA Inhibitor DMY49DN RN Isosorbide-2-carbamate esters: potent and selective butyrylcholinesterase inhibitors. J Med Chem. 2008 Oct 23;51(20):6400-9. DMY49DN RU https://pubmed.ncbi.nlm.nih.gov/18817366 DMSQ538 DI DMSQ538 DMSQ538 DN Isosorbide-2-benzylcarbamate-5-pentanoate DMSQ538 MI TTEB0GD DMSQ538 MN Cholinesterase (BCHE) DMSQ538 MT DTT DMSQ538 MA Inhibitor DMSQ538 RN Isosorbide-2-carbamate esters: potent and selective butyrylcholinesterase inhibitors. J Med Chem. 2008 Oct 23;51(20):6400-9. DMSQ538 RU https://pubmed.ncbi.nlm.nih.gov/18817366 DMP6E34 DI DMP6E34 DMP6E34 DN Isosorbide-2-benzylcarbamate-5-propionate DMP6E34 MI TTEB0GD DMP6E34 MN Cholinesterase (BCHE) DMP6E34 MT DTT DMP6E34 MA Inhibitor DMP6E34 RN Isosorbide-2-carbamate esters: potent and selective butyrylcholinesterase inhibitors. J Med Chem. 2008 Oct 23;51(20):6400-9. DMP6E34 RU https://pubmed.ncbi.nlm.nih.gov/18817366 DMCHSWQ DI DMCHSWQ DMCHSWQ DN Isosorbide-2-benzylcarbamate-5-tosylate DMCHSWQ MI TT1RS9F DMCHSWQ MN Acetylcholinesterase (AChE) DMCHSWQ MT DTT DMCHSWQ MA Inhibitor DMCHSWQ RN Isosorbide-2-carbamate esters: potent and selective butyrylcholinesterase inhibitors. J Med Chem. 2008 Oct 23;51(20):6400-9. DMCHSWQ RU https://pubmed.ncbi.nlm.nih.gov/18817366 DMG69IX DI DMG69IX DMG69IX DN Isosorbide-2-benzylcarbamate-5-triflate DMG69IX MI TTEB0GD DMG69IX MN Cholinesterase (BCHE) DMG69IX MT DTT DMG69IX MA Inhibitor DMG69IX RN Isosorbide-2-carbamate esters: potent and selective butyrylcholinesterase inhibitors. J Med Chem. 2008 Oct 23;51(20):6400-9. DMG69IX RU https://pubmed.ncbi.nlm.nih.gov/18817366 DMPA2ON DI DMPA2ON DMPA2ON DN Isosorbide-di-(4-nitrophenyl carbamate) DMPA2ON MI TT1RS9F DMPA2ON MN Acetylcholinesterase (AChE) DMPA2ON MT DTT DMPA2ON MA Inhibitor DMPA2ON RN Isosorbide-based cholinesterase inhibitors; replacement of 5-ester groups leading to increased stability. Bioorg Med Chem. 2010 Feb;18(3):1045-53. DMPA2ON RU https://pubmed.ncbi.nlm.nih.gov/20093035 DMFVN71 DI DMFVN71 DMFVN71 DN Isosorbide-di-(benzylcarbamate) DMFVN71 MI TT1RS9F DMFVN71 MN Acetylcholinesterase (AChE) DMFVN71 MT DTT DMFVN71 MA Inhibitor DMFVN71 RN Isosorbide-based cholinesterase inhibitors; replacement of 5-ester groups leading to increased stability. Bioorg Med Chem. 2010 Feb;18(3):1045-53. DMFVN71 RU https://pubmed.ncbi.nlm.nih.gov/20093035 DMFVN71 DI DMFVN71 DMFVN71 DN Isosorbide-di-(benzylcarbamate) DMFVN71 MI TTEB0GD DMFVN71 MN Cholinesterase (BCHE) DMFVN71 MT DTT DMFVN71 MA Inhibitor DMFVN71 RN Isosorbide-based cholinesterase inhibitors; replacement of 5-ester groups leading to increased stability. Bioorg Med Chem. 2010 Feb;18(3):1045-53. DMFVN71 RU https://pubmed.ncbi.nlm.nih.gov/20093035 DMNSTKD DI DMNSTKD DMNSTKD DN Isosorbide-di-(butylcarbamate) DMNSTKD MI TTEB0GD DMNSTKD MN Cholinesterase (BCHE) DMNSTKD MT DTT DMNSTKD MA Inhibitor DMNSTKD RN Isosorbide-based cholinesterase inhibitors; replacement of 5-ester groups leading to increased stability. Bioorg Med Chem. 2010 Feb;18(3):1045-53. DMNSTKD RU https://pubmed.ncbi.nlm.nih.gov/20093035 DMTHWXO DI DMTHWXO DMTHWXO DN Isosorbide-di-(ethylcarbamate) DMTHWXO MI TT1RS9F DMTHWXO MN Acetylcholinesterase (AChE) DMTHWXO MT DTT DMTHWXO MA Inhibitor DMTHWXO RN Isosorbide-based cholinesterase inhibitors; replacement of 5-ester groups leading to increased stability. Bioorg Med Chem. 2010 Feb;18(3):1045-53. DMTHWXO RU https://pubmed.ncbi.nlm.nih.gov/20093035 DMTHWXO DI DMTHWXO DMTHWXO DN Isosorbide-di-(ethylcarbamate) DMTHWXO MI TTEB0GD DMTHWXO MN Cholinesterase (BCHE) DMTHWXO MT DTT DMTHWXO MA Inhibitor DMTHWXO RN Isosorbide-based cholinesterase inhibitors; replacement of 5-ester groups leading to increased stability. Bioorg Med Chem. 2010 Feb;18(3):1045-53. DMTHWXO RU https://pubmed.ncbi.nlm.nih.gov/20093035 DMV1GLP DI DMV1GLP DMV1GLP DN Isosorbide-di-(propylcarbamate) DMV1GLP MI TTEB0GD DMV1GLP MN Cholinesterase (BCHE) DMV1GLP MT DTT DMV1GLP MA Inhibitor DMV1GLP RN Isosorbide-based cholinesterase inhibitors; replacement of 5-ester groups leading to increased stability. Bioorg Med Chem. 2010 Feb;18(3):1045-53. DMV1GLP RU https://pubmed.ncbi.nlm.nih.gov/20093035 DMT1ZGM DI DMT1ZGM DMT1ZGM DN Isosorbide-di-phenylcarbamate DMT1ZGM MI TT1RS9F DMT1ZGM MN Acetylcholinesterase (AChE) DMT1ZGM MT DTT DMT1ZGM MA Inhibitor DMT1ZGM RN Isosorbide-based cholinesterase inhibitors; replacement of 5-ester groups leading to increased stability. Bioorg Med Chem. 2010 Feb;18(3):1045-53. DMT1ZGM RU https://pubmed.ncbi.nlm.nih.gov/20093035 DM21K0E DI DM21K0E DM21K0E DN ISOTETRANDRINE DM21K0E MI TTVBI8W DM21K0E MN Dopamine transporter (DAT) DM21K0E MT DTT DM21K0E MA Inhibitor DM21K0E RN Effects of various isoquinoline alkaloids on in vitro 3H-dopamine uptake by rat striatal synaptosomes. J Nat Prod. 1995 Oct;58(10):1475-84. DM21K0E RU https://pubmed.ncbi.nlm.nih.gov/8676127 DMKTBEH DI DMKTBEH DMKTBEH DN ISOTHIAZOLIDINONE ANALOG DMKTBEH MI TTELIN2 DMKTBEH MN PTPN1 messenger RNA (PTPN1 mRNA) DMKTBEH MT DTT DMKTBEH MA Inhibitor DMKTBEH RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DMKTBEH RU https://pubmed.ncbi.nlm.nih.gov/10592235 DMAYOTF DI DMAYOTF DMAYOTF DN isothiourea-1a DMAYOTF MI TTBID49 DMAYOTF MN C-X-C chemokine receptor type 4 (CXCR4) DMAYOTF MT DTT DMAYOTF MA Antagonist DMAYOTF RN Orally bioavailable isothioureas block function of the chemokine receptor CXCR4 in vitro and in vivo. J Med Chem. 2008 Dec 25;51(24):7915-20. DMAYOTF RU https://pubmed.ncbi.nlm.nih.gov/19053768 DMBX4WR DI DMBX4WR DMBX4WR DN isothiourea-1t DMBX4WR MI TTBID49 DMBX4WR MN C-X-C chemokine receptor type 4 (CXCR4) DMBX4WR MT DTT DMBX4WR MA Antagonist DMBX4WR RN Orally bioavailable isothioureas block function of the chemokine receptor CXCR4 in vitro and in vivo. J Med Chem. 2008 Dec 25;51(24):7915-20. DMBX4WR RU https://pubmed.ncbi.nlm.nih.gov/19053768 DMNL0BK DI DMNL0BK DMNL0BK DN IsoVa-RYYRIK-NH2 DMNL0BK MI TTNT7K8 DMNL0BK MN Nociceptin receptor (OPRL1) DMNL0BK MT DTT DMNL0BK MA Inhibitor DMNL0BK RN Designed modification of partial agonist of ORL1 nociceptin receptor for conversion into highly potent antagonist. Bioorg Med Chem. 2008 Mar 1;16(5):2635-44. DMNL0BK RU https://pubmed.ncbi.nlm.nih.gov/18068993 DMTRGAP DI DMTRGAP DMTRGAP DN isovelleral DMTRGAP MI TTELV3W DMTRGAP MN Transformation-sensitive protein p120 (TRPA1) DMTRGAP MT DTT DMTRGAP MA Activator DMTRGAP RN TRPA1 mediates the noxious effects of natural sesquiterpene deterrents. J Biol Chem. 2008 Aug 29;283(35):24136-44. DMTRGAP RU https://pubmed.ncbi.nlm.nih.gov/18550530 DMXAD8E DI DMXAD8E DMXAD8E DN Isoxazol DMXAD8E MI TT3PQ2Y DMXAD8E MN Plasmodium Dihydroorotate dehydrogenase (Malaria DHOdehase) DMXAD8E MT DTT DMXAD8E MA Inhibitor DMXAD8E RN Kinetics of inhibition of human and rat dihydroorotate dehydrogenase by atovaquone, lawsone derivatives, brequinar sodium and polyporic acid. Chem Biol Interact. 2000 Jan 3;124(1):61-76. DMXAD8E RU https://pubmed.ncbi.nlm.nih.gov/10658902 DMAFC3R DI DMAFC3R DMAFC3R DN isoxazole azepine compound 3 DMAFC3R MI TTRA6BO DMAFC3R MN Bromodomain-containing protein 4 (BRD4) DMAFC3R MT DTT DMAFC3R MA Inhibitor DMAFC3R RN Discovery, Design, and Optimization of Isoxazole Azepine BET Inhibitors. ACS Med Chem Lett. 2013 Jul 16;4(9):835-40. DMAFC3R RU https://pubmed.ncbi.nlm.nih.gov/24900758 DMPZURH DI DMPZURH DMPZURH DN Isoxazolecarboxylic acid DMPZURH MI TTELIN2 DMPZURH MN PTPN1 messenger RNA (PTPN1 mRNA) DMPZURH MT DTT DMPZURH MA Inhibitor DMPZURH RN Synthesis and evaluation of some novel dibenzo[b,d]furan carboxylic acids as potential anti-diabetic agents. Eur J Med Chem. 2010 Sep;45(9):3709-18. DMPZURH RU https://pubmed.ncbi.nlm.nih.gov/20627471 DMA8F4N DI DMA8F4N DMA8F4N DN ITdU DMA8F4N MI TTP3QRF DMA8F4N MN Thymidine kinase 1 (TK1) DMA8F4N MT DTT DMA8F4N MA Inhibitor DMA8F4N RN Trichomonas vaginalis thymidine kinase: purification, characterization and search for inhibitors. Biochem J. 1998 Aug 15;334 ( Pt 1):15-22. DMA8F4N RU https://pubmed.ncbi.nlm.nih.gov/9693096 DMVFITX DI DMVFITX DMVFITX DN ITP DMVFITX MI TT24DGP DMVFITX MN P2Y purinoceptor 4 (P2RY4) DMVFITX MT DTT DMVFITX MA Agonist DMVFITX RN ATP, an agonist at the rat P2Y(4) receptor, is an antagonist at the human P2Y(4) receptor. Mol Pharmacol. 2000 May;57(5):926-31. DMVFITX RU https://pubmed.ncbi.nlm.nih.gov/10779375 DMWTDS8 DI DMWTDS8 DMWTDS8 DN ITRI-305 DMWTDS8 MI TT4DXQT DMWTDS8 MN Proto-oncogene c-Ret (RET) DMWTDS8 MT DTT DMWTDS8 MA Inhibitor DMWTDS8 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2185). DMWTDS8 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2185 DMFMYIH DI DMFMYIH DMFMYIH DN Iva-His-Pro-Phe-His-ACHPA-Leu-Phe-NH2 DMFMYIH MI TTB2MXP DMFMYIH MN Angiotensinogenase renin (REN) DMFMYIH MT DTT DMFMYIH MA Inhibitor DMFMYIH RN Renin inhibitors. Syntheses of subnanomolar, competitive, transition-state analogue inhibitors containing a novel analogue of statine. J Med Chem. 1985 Dec;28(12):1779-90. DMFMYIH RU https://pubmed.ncbi.nlm.nih.gov/3906131 DMZTIU3 DI DMZTIU3 DMZTIU3 DN Iva-His-Pro-Phe-His-AHPPA-Leu-Phe-NH2 DMZTIU3 MI TTB2MXP DMZTIU3 MN Angiotensinogenase renin (REN) DMZTIU3 MT DTT DMZTIU3 MA Inhibitor DMZTIU3 RN Renin inhibitors. Syntheses of subnanomolar, competitive, transition-state analogue inhibitors containing a novel analogue of statine. J Med Chem. 1985 Dec;28(12):1779-90. DMZTIU3 RU https://pubmed.ncbi.nlm.nih.gov/3906131 DM92QIW DI DM92QIW DM92QIW DN Iva-His-Pro-Phe-His-Sta-Leu-Phe-NH2 DM92QIW MI TTB2MXP DM92QIW MN Angiotensinogenase renin (REN) DM92QIW MT DTT DM92QIW MA Inhibitor DM92QIW RN Renin inhibitors. Syntheses of subnanomolar, competitive, transition-state analogue inhibitors containing a novel analogue of statine. J Med Chem. 1985 Dec;28(12):1779-90. DM92QIW RU https://pubmed.ncbi.nlm.nih.gov/3906131 DMBTWF0 DI DMBTWF0 DMBTWF0 DN IW-1221 DMBTWF0 MI TTQDMX5 DMBTWF0 MN Prostaglandin D2 receptor 2 (PTGDR2) DMBTWF0 MT DTT DMBTWF0 MA Inhibitor DMBTWF0 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 339). DMBTWF0 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=339 DMQSB6N DI DMQSB6N DMQSB6N DN J-009747 DMQSB6N MI DE8RYV5 DMQSB6N MN NADPH:quinone reductase (CRYZ) DMQSB6N MT DME DMQSB6N MA Metabolism DMQSB6N RN Kinetic and structural evidence of the alkenal/one reductase specificity of human crystallin. Cell Mol Life Sci. 2011 Mar;68(6):1065-77. DMQSB6N RU https://www.ncbi.nlm.nih.gov/pubmed/?term=20835842 DMQ8J3M DI DMQ8J3M DMQ8J3M DN J-104118 DMQ8J3M MI TTFQEO5 DMQ8J3M MN Squalene synthetase (FDFT1) DMQ8J3M MT DTT DMQ8J3M MA Inhibitor DMQ8J3M RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 645). DMQ8J3M RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=645 DMWF7RO DI DMWF7RO DMWF7RO DN J-104123 DMWF7RO MI TTFQEO5 DMWF7RO MN Squalene synthetase (FDFT1) DMWF7RO MT DTT DMWF7RO MA Inhibitor DMWF7RO RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 645). DMWF7RO RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=645 DMAEQS9 DI DMAEQS9 DMAEQS9 DN J-104135 DMAEQS9 MI TTQ13Z5 DMAEQS9 MN Muscarinic acetylcholine receptor M3 (CHRM3) DMAEQS9 MT DTT DMAEQS9 MA Agonist DMAEQS9 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 15). DMAEQS9 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=15 DMCS4BL DI DMCS4BL DMCS4BL DN J-104870 DMCS4BL MI TTRK9JT DMCS4BL MN Neuropeptide Y receptor type 1 (NPY1R) DMCS4BL MT DTT DMCS4BL MA Antagonist DMCS4BL RN The novel neuropeptide Y Y(1) receptor antagonist J-104870: a potent feeding suppressant with oral bioavailability. Biochem Biophys Res Commun. 1999 Dec 9;266(1):88-91. DMCS4BL RU https://pubmed.ncbi.nlm.nih.gov/10581170 DM9SFGB DI DM9SFGB DM9SFGB DN J-109,390 DM9SFGB MI TTX20QP DM9SFGB MN Geranylgeranyl transferase I (GGTase-I) DM9SFGB MT DTT DM9SFGB MA Inhibitor DM9SFGB RN Geranylgeranyltransferase I of Candida albicans: null mutants or enzyme inhibitors produce unexpected phenotypes. J Bacteriol. 2000 Feb;182(3):704-13. DM9SFGB RU https://pubmed.ncbi.nlm.nih.gov/10633104 DMXC319 DI DMXC319 DMXC319 DN J591-Ac-225 DMXC319 MI TT9G4N0 DMXC319 MN Glutamate carboxypeptidase II (GCPII) DMXC319 MT DTT DMXC319 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1606). DMXC319 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1606 DMJAEMT DI DMJAEMT DMJAEMT DN JASPAQUINOL DMJAEMT MI TTN9T81 DMJAEMT MN Arachidonate 15-lipoxygenase (15-LOX) DMJAEMT MT DTT DMJAEMT MA Inhibitor DMJAEMT RN Using enzyme assays to evaluate the structure and bioactivity of sponge-derived meroterpenes. J Nat Prod. 2009 Oct;72(10):1857-63. DMJAEMT RU https://pubmed.ncbi.nlm.nih.gov/19848434 DMJAEMT DI DMJAEMT DMJAEMT DN JASPAQUINOL DMJAEMT MI TTSJ6Q4 DMJAEMT MN LOX-5 messenger RNA (ALOX5 mRNA) DMJAEMT MT DTT DMJAEMT MA Inhibitor DMJAEMT RN Using enzyme assays to evaluate the structure and bioactivity of sponge-derived meroterpenes. J Nat Prod. 2009 Oct;72(10):1857-63. DMJAEMT RU https://pubmed.ncbi.nlm.nih.gov/19848434 DMOF0TB DI DMOF0TB DMOF0TB DN Jaspic acid DMOF0TB MI TT12ABZ DMOF0TB MN Arachidonate 12-lipoxygenase (12-LOX) DMOF0TB MT DTT DMOF0TB MA Inhibitor DMOF0TB RN Exploring sponge-derived terpenoids for their potency and selectivity against 12-human, 15-human, and 15-soybean lipoxygenases. J Nat Prod. 2003 Feb;66(2):230-5. DMOF0TB RU https://pubmed.ncbi.nlm.nih.gov/12608855 DMOF0TB DI DMOF0TB DMOF0TB DN Jaspic acid DMOF0TB MI TTN9T81 DMOF0TB MN Arachidonate 15-lipoxygenase (15-LOX) DMOF0TB MT DTT DMOF0TB MA Inhibitor DMOF0TB RN Exploring sponge-derived terpenoids for their potency and selectivity against 12-human, 15-human, and 15-soybean lipoxygenases. J Nat Prod. 2003 Feb;66(2):230-5. DMOF0TB RU https://pubmed.ncbi.nlm.nih.gov/12608855 DMYFNW9 DI DMYFNW9 DMYFNW9 DN JATRORRHIZINE DMYFNW9 MI TTXV4FI DMYFNW9 MN Albendazole monooxygenase (CYP3A4) DMYFNW9 MT DTT DMYFNW9 MA Inhibitor DMYFNW9 RN Cytochrome P3A4 inhibitors and other constituents of Fibraurea tinctoria. J Nat Prod. 2007 Dec;70(12):1930-3. DMYFNW9 RU https://pubmed.ncbi.nlm.nih.gov/17994701 DMPRTVX DI DMPRTVX DMPRTVX DN JB 98064 DMPRTVX MI TT9JNIC DMPRTVX MN Histamine H3 receptor (H3R) DMPRTVX MT DTT DMPRTVX MA Antagonist DMPRTVX RN Characteristics of recombinantly expressed rat and human histamine H3 receptors. Eur J Pharmacol. 2002 Oct 18;453(1):33-41. DMPRTVX RU https://pubmed.ncbi.nlm.nih.gov/12393057 DM38L1B DI DM38L1B DM38L1B DN JB-1 DM38L1B MI TTHRID2 DM38L1B MN Insulin-like growth factor I receptor (IGF1R) DM38L1B MT DTT DM38L1B MA Inhibitor DM38L1B RN Emerging therapies for multiple myeloma. Expert Opin Emerg Drugs. 2009 Mar;14(1):99-127. DM38L1B RU https://pubmed.ncbi.nlm.nih.gov/19249983 DM0KMPN DI DM0KMPN DM0KMPN DN JBP-1 DM0KMPN MI TTHCF4J DM0KMPN MN Alpha-glucosidase (GLA) DM0KMPN MT DTT DM0KMPN MA Modulator DM0KMPN RN US patent application no. 2012,0251,516, PHARMACEUTICAL COMPOSITION FOR TREATING CANCER COMPRISING TRYPSINOGEN AND/OR CHYMOTRYPSINOGEN AND AN ACTIVE AGENT SELECTED FROM A SELENIUM COMPOUND, A VANILLOID COMPOUND AND A CYTOPLASMIC GLYCOLYSIS REDUCTION AGENT. DM0KMPN RU http://www.patentbuddy.com/Patent/20120251516?ft=true&sr=true DM0KMPN DI DM0KMPN DM0KMPN DN JBP-1 DM0KMPN MI TT2WR1T DM0KMPN MN Cationic trypsinogen (PRSS1) DM0KMPN MT DTT DM0KMPN MA Modulator DM0KMPN RN US patent application no. 2012,0251,516, PHARMACEUTICAL COMPOSITION FOR TREATING CANCER COMPRISING TRYPSINOGEN AND/OR CHYMOTRYPSINOGEN AND AN ACTIVE AGENT SELECTED FROM A SELENIUM COMPOUND, A VANILLOID COMPOUND AND A CYTOPLASMIC GLYCOLYSIS REDUCTION AGENT. DM0KMPN RU http://www.patentbuddy.com/Patent/20120251516?ft=true&sr=true DM0KMPN DI DM0KMPN DM0KMPN DN JBP-1 DM0KMPN MI TT7MRGU DM0KMPN MN Chymotrypsin (CTR) DM0KMPN MT DTT DM0KMPN MA Modulator DM0KMPN RN US patent application no. 2012,0251,516, PHARMACEUTICAL COMPOSITION FOR TREATING CANCER COMPRISING TRYPSINOGEN AND/OR CHYMOTRYPSINOGEN AND AN ACTIVE AGENT SELECTED FROM A SELENIUM COMPOUND, A VANILLOID COMPOUND AND A CYTOPLASMIC GLYCOLYSIS REDUCTION AGENT. DM0KMPN RU http://www.patentbuddy.com/Patent/20120251516?ft=true&sr=true DMYF7AE DI DMYF7AE DMYF7AE DN JCF 109 DMYF7AE MI TTY6EWA DMYF7AE MN Neuropeptide Y receptor type 5 (NPY5R) DMYF7AE MT DTT DMYF7AE MA Antagonist DMYF7AE RN Development and characterization of a highly selective neuropeptide Y Y5 receptor agonist radioligand: [125I][hPP1-17, Ala31, Aib32]NPY. Br J Pharmacol. 2003 Aug;139(7):1360-8. DMYF7AE RU https://pubmed.ncbi.nlm.nih.gov/12890716 DMLBX3Q DI DMLBX3Q DMLBX3Q DN JD-0100 DMLBX3Q MI TTGP7BY DMLBX3Q MN Monoamine oxidase type B (MAO-B) DMLBX3Q MT DTT DMLBX3Q MA Inhibitor DMLBX3Q RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2490). DMLBX3Q RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2490 DMQP4VG DI DMQP4VG DMQP4VG DN JG-365 DMQP4VG MI TT5FNQT DMQP4VG MN Human immunodeficiency virus Protease (HIV PR) DMQP4VG MT DTT DMQP4VG MA Modulator DMQP4VG RN [Mechanism of action of aspartic proteases. III. Conformational characteristics of HIV-1 protease inhibitor JG-365]. Bioorg Khim. 1999 Jun;25(6):418-22. DMQP4VG RU https://www.ncbi.nlm.nih.gov/pubmed/10505229 DM0LD3F DI DM0LD3F DM0LD3F DN JL-18 DM0LD3F MI TTE0A2F DM0LD3F MN Dopamine D4 receptor (D4R) DM0LD3F MT DTT DM0LD3F MA Inhibitor DM0LD3F RN (S)-(-)-4-[4-[2-(isochroman-1-yl)ethyl]-piperazin-1-yl] benzenesulfonamide, a selective dopamine D4 antagonist. J Med Chem. 1996 Jun 21;39(13):2435-7. DM0LD3F RU https://pubmed.ncbi.nlm.nih.gov/8691438 DMWMRO2 DI DMWMRO2 DMWMRO2 DN JM-1232(-) DMWMRO2 MI TTEX6LM DMWMRO2 MN GABA(A) receptor gamma-3 (GABRG3) DMWMRO2 MT DTT DMWMRO2 MA Agonist DMWMRO2 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 415). DMWMRO2 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=415 DMP1B9D DI DMP1B9D DMP1B9D DN JMV 1535 DMP1B9D MI TTC1MVT DMP1B9D MN Gastrin-releasing peptide receptor (GRPR) DMP1B9D MT DTT DMP1B9D MA Inhibitor DMP1B9D RN Synthesis and biological evaluation of bombesin constrained analogues. J Med Chem. 2000 Jun 15;43(12):2356-61. DMP1B9D RU https://pubmed.ncbi.nlm.nih.gov/10882361 DMARTN3 DI DMARTN3 DMARTN3 DN JMV 1693 DMARTN3 MI TTC1MVT DMARTN3 MN Gastrin-releasing peptide receptor (GRPR) DMARTN3 MT DTT DMARTN3 MA Inhibitor DMARTN3 RN Synthesis and biological evaluation of bombesin constrained analogues. J Med Chem. 2000 Jun 15;43(12):2356-61. DMARTN3 RU https://pubmed.ncbi.nlm.nih.gov/10882361 DM82HW9 DI DM82HW9 DM82HW9 DN JMV 1719 DM82HW9 MI TTC1MVT DM82HW9 MN Gastrin-releasing peptide receptor (GRPR) DM82HW9 MT DTT DM82HW9 MA Inhibitor DM82HW9 RN Synthesis and biological evaluation of bombesin constrained analogues. J Med Chem. 2000 Jun 15;43(12):2356-61. DM82HW9 RU https://pubmed.ncbi.nlm.nih.gov/10882361 DMX3P68 DI DMX3P68 DMX3P68 DN JMV 1799 DMX3P68 MI TTC1MVT DMX3P68 MN Gastrin-releasing peptide receptor (GRPR) DMX3P68 MT DTT DMX3P68 MA Inhibitor DMX3P68 RN Synthesis and biological evaluation of bombesin constrained analogues. J Med Chem. 2000 Jun 15;43(12):2356-61. DMX3P68 RU https://pubmed.ncbi.nlm.nih.gov/10882361 DMTX694 DI DMTX694 DMTX694 DN JMV 1801 DMTX694 MI TTC1MVT DMTX694 MN Gastrin-releasing peptide receptor (GRPR) DMTX694 MT DTT DMTX694 MA Inhibitor DMTX694 RN Synthesis and biological evaluation of bombesin constrained analogues. J Med Chem. 2000 Jun 15;43(12):2356-61. DMTX694 RU https://pubmed.ncbi.nlm.nih.gov/10882361 DMGT6DN DI DMGT6DN DMGT6DN DN JMV 1802 DMGT6DN MI TTC1MVT DMGT6DN MN Gastrin-releasing peptide receptor (GRPR) DMGT6DN MT DTT DMGT6DN MA Inhibitor DMGT6DN RN Synthesis and biological evaluation of bombesin constrained analogues. J Med Chem. 2000 Jun 15;43(12):2356-61. DMGT6DN RU https://pubmed.ncbi.nlm.nih.gov/10882361 DM248HC DI DM248HC DM248HC DN JMV 1803 DM248HC MI TTC1MVT DM248HC MN Gastrin-releasing peptide receptor (GRPR) DM248HC MT DTT DM248HC MA Inhibitor DM248HC RN Synthesis and biological evaluation of bombesin constrained analogues. J Med Chem. 2000 Jun 15;43(12):2356-61. DM248HC RU https://pubmed.ncbi.nlm.nih.gov/10882361 DMSICYK DI DMSICYK DMSICYK DN JMV 1813 DMSICYK MI TTC1MVT DMSICYK MN Gastrin-releasing peptide receptor (GRPR) DMSICYK MT DTT DMSICYK MA Inhibitor DMSICYK RN Synthesis and biological evaluation of bombesin constrained analogues. J Med Chem. 2000 Jun 15;43(12):2356-61. DMSICYK RU https://pubmed.ncbi.nlm.nih.gov/10882361 DMAR3M2 DI DMAR3M2 DMAR3M2 DN JMV1431 DMAR3M2 MI TTG5QIA DMAR3M2 MN B1 bradykinin receptor (BDKRB1) DMAR3M2 MT DTT DMAR3M2 MA Inhibitor DMAR3M2 RN Synthesis and biological evaluation of bradykinin B(1)/B(2) and selective B(1) receptor antagonists. J Med Chem. 2000 Jun 15;43(12):2382-6. DMAR3M2 RU https://pubmed.ncbi.nlm.nih.gov/10882364 DMAR3M2 DI DMAR3M2 DMAR3M2 DN JMV1431 DMAR3M2 MI TTGY8IW DMAR3M2 MN B2 bradykinin receptor (BDKRB2) DMAR3M2 MT DTT DMAR3M2 MA Antagonist DMAR3M2 RN Synthesis and biological evaluation of bradykinin B(1)/B(2) and selective B(1) receptor antagonists. J Med Chem. 2000 Jun 15;43(12):2382-6. DMAR3M2 RU https://pubmed.ncbi.nlm.nih.gov/10882364 DM5G0IM DI DM5G0IM DM5G0IM DN JMV180 DM5G0IM MI TTCG0AL DM5G0IM MN Cholecystokinin receptor type A (CCKAR) DM5G0IM MT DTT DM5G0IM MA Agonist DM5G0IM RN Identification of a region of the N-terminal of the human CCKA receptor essential for the high affinity interaction with agonist CCK. Biochem Biophys Res Commun. 1995 Aug 24;213(3):845-52. DM5G0IM RU https://pubmed.ncbi.nlm.nih.gov/7654246 DMB9U17 DI DMB9U17 DMB9U17 DN JMV3008 DMB9U17 MI TTWDC17 DMB9U17 MN Growth hormone secretagogue receptor 1 (GHSR) DMB9U17 MT DTT DMB9U17 MA Antagonist DMB9U17 RN Toward potent ghrelin receptor ligands based on trisubstituted 1,2,4-triazole structure. 2. Synthesis and pharmacological in vitro and in vivo eval... J Med Chem. 2007 Nov 15;50(23):5790-806. DMB9U17 RU https://pubmed.ncbi.nlm.nih.gov/17927165 DME9GF8 DI DME9GF8 DME9GF8 DN JMV449 DME9GF8 MI TTTUMEP DME9GF8 MN Neurotensin receptor type 1 (NTSR1) DME9GF8 MT DTT DME9GF8 MA Agonist DME9GF8 RN Differential involvement of intracellular domains of the rat NTS1 neurotensin receptor in coupling to G proteins: a molecular basis for agonist-directed trafficking of receptor stimulus. Mol Pharmacol. 2003 Aug;64(2):421-9. DME9GF8 RU https://pubmed.ncbi.nlm.nih.gov/12869647 DMC1ARG DI DMC1ARG DMC1ARG DN JMV458 DMC1ARG MI TTTUMEP DMC1ARG MN Neurotensin receptor type 1 (NTSR1) DMC1ARG MT DTT DMC1ARG MA Agonist DMC1ARG RN Agonism, inverse agonism, and neutral antagonism at the constitutively active human neurotensin receptor 2. Mol Pharmacol. 2001 Dec;60(6):1392-8. DMC1ARG RU https://pubmed.ncbi.nlm.nih.gov/11723247 DMC1ARG DI DMC1ARG DMC1ARG DN JMV458 DMC1ARG MI TT31Q0V DMC1ARG MN Neurotensin receptor type 2 (NTSR2) DMC1ARG MT DTT DMC1ARG MA Agonist DMC1ARG RN Agonism, inverse agonism, and neutral antagonism at the constitutively active human neurotensin receptor 2. Mol Pharmacol. 2001 Dec;60(6):1392-8. DMC1ARG RU https://pubmed.ncbi.nlm.nih.gov/11723247 DMFU76I DI DMFU76I DMFU76I DN JN-711 DMFU76I MI TTLA931 DMFU76I MN Neuronal acetylcholine receptor alpha-7 (CHRNA7) DMFU76I MT DTT DMFU76I MA Agonist DMFU76I RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 468). DMFU76I RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=468 DM6P1UA DI DM6P1UA DM6P1UA DN JNJ-10191584 DM6P1UA MI TTXJ178 DM6P1UA MN Histamine H4 receptor (H4R) DM6P1UA MT DTT DM6P1UA MA Antagonist DM6P1UA RN Synthesis and structure-activity relationships of indole and benzimidazole piperazines as histamine H(4) receptor antagonists. Bioorg Med Chem Lett. 2004 Nov 1;14(21):5251-6. DM6P1UA RU https://pubmed.ncbi.nlm.nih.gov/15454206 DM9GDP5 DI DM9GDP5 DM9GDP5 DN JNJ-10198409 DM9GDP5 MI TT2B9KF DM9GDP5 MN Fyn tyrosine protein kinase (FYN) DM9GDP5 MT DTT DM9GDP5 MA Inhibitor DM9GDP5 RN (6,7-Dimethoxy-2,4-dihydroindeno[1,2-c]pyrazol-3-yl)phenylamines: platelet-derived growth factor receptor tyrosine kinase inhibitors with broad ant... J Med Chem. 2005 Dec 29;48(26):8163-73. DM9GDP5 RU https://pubmed.ncbi.nlm.nih.gov/16366598 DM9GDP5 DI DM9GDP5 DM9GDP5 DN JNJ-10198409 DM9GDP5 MI TT860QF DM9GDP5 MN LCK tyrosine protein kinase (LCK) DM9GDP5 MT DTT DM9GDP5 MA Inhibitor DM9GDP5 RN (6,7-Dimethoxy-2,4-dihydroindeno[1,2-c]pyrazol-3-yl)phenylamines: platelet-derived growth factor receptor tyrosine kinase inhibitors with broad ant... J Med Chem. 2005 Dec 29;48(26):8163-73. DM9GDP5 RU https://pubmed.ncbi.nlm.nih.gov/16366598 DM9GDP5 DI DM9GDP5 DM9GDP5 DN JNJ-10198409 DM9GDP5 MI TT8FYO9 DM9GDP5 MN Platelet-derived growth factor receptor alpha (PDGFRA) DM9GDP5 MT DTT DM9GDP5 MA Inhibitor DM9GDP5 RN (6,7-Dimethoxy-2,4-dihydroindeno[1,2-c]pyrazol-3-yl)phenylamines: platelet-derived growth factor receptor tyrosine kinase inhibitors with broad ant... J Med Chem. 2005 Dec 29;48(26):8163-73. DM9GDP5 RU https://pubmed.ncbi.nlm.nih.gov/16366598 DM9GDP5 DI DM9GDP5 DM9GDP5 DN JNJ-10198409 DM9GDP5 MI TTI7421 DM9GDP5 MN Platelet-derived growth factor receptor beta (PDGFRB) DM9GDP5 MT DTT DM9GDP5 MA Inhibitor DM9GDP5 RN (6,7-Dimethoxy-2,4-dihydroindeno[1,2-c]pyrazol-3-yl)phenylamines: platelet-derived growth factor receptor tyrosine kinase inhibitors with broad ant... J Med Chem. 2005 Dec 29;48(26):8163-73. DM9GDP5 RU https://pubmed.ncbi.nlm.nih.gov/16366598 DM9GDP5 DI DM9GDP5 DM9GDP5 DN JNJ-10198409 DM9GDP5 MI TT6PKBN DM9GDP5 MN Proto-oncogene c-Src (SRC) DM9GDP5 MT DTT DM9GDP5 MA Inhibitor DM9GDP5 RN (6,7-Dimethoxy-2,4-dihydroindeno[1,2-c]pyrazol-3-yl)phenylamines: platelet-derived growth factor receptor tyrosine kinase inhibitors with broad ant... J Med Chem. 2005 Dec 29;48(26):8163-73. DM9GDP5 RU https://pubmed.ncbi.nlm.nih.gov/16366598 DM9GDP5 DI DM9GDP5 DM9GDP5 DN JNJ-10198409 DM9GDP5 MI TT3PJMV DM9GDP5 MN Tyrosine-protein kinase ABL1 (ABL) DM9GDP5 MT DTT DM9GDP5 MA Inhibitor DM9GDP5 RN (6,7-Dimethoxy-2,4-dihydroindeno[1,2-c]pyrazol-3-yl)phenylamines: platelet-derived growth factor receptor tyrosine kinase inhibitors with broad ant... J Med Chem. 2005 Dec 29;48(26):8163-73. DM9GDP5 RU https://pubmed.ncbi.nlm.nih.gov/16366598 DMBRJ3C DI DMBRJ3C DMBRJ3C DN JNJ-10329670 DMBRJ3C MI TTUMQVO DMBRJ3C MN Cathepsin S (CTSS) DMBRJ3C MT DTT DMBRJ3C MA Inhibitor DMBRJ3C RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2353). DMBRJ3C RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2353 DMZH0K8 DI DMZH0K8 DMZH0K8 DN JNJ-10392980 DMZH0K8 MI TTSQIFT DMZH0K8 MN 5-HT 1A receptor (HTR1A) DMZH0K8 MT DTT DMZH0K8 MA Inhibitor DMZH0K8 RN Identification of a potent, selective, and orally active leukotriene a4 hydrolase inhibitor with anti-inflammatory activity. J Med Chem. 2008 Jul 24;51(14):4150-69. DMZH0K8 RU https://pubmed.ncbi.nlm.nih.gov/18588282 DMZH0K8 DI DMZH0K8 DMZH0K8 DN JNJ-10392980 DMZH0K8 MI TTXZEAJ DMZH0K8 MN Leukotriene A-4 hydrolase (LTA4H) DMZH0K8 MT DTT DMZH0K8 MA Inhibitor DMZH0K8 RN Identification of a potent, selective, and orally active leukotriene a4 hydrolase inhibitor with anti-inflammatory activity. J Med Chem. 2008 Jul 24;51(14):4150-69. DMZH0K8 RU https://pubmed.ncbi.nlm.nih.gov/18588282 DMZH0K8 DI DMZH0K8 DMZH0K8 DN JNJ-10392980 DMZH0K8 MI TTQ6VDM DMZH0K8 MN Voltage-gated potassium channel Kv11.1 (KCNH2) DMZH0K8 MT DTT DMZH0K8 MA Inhibitor DMZH0K8 RN Identification of a potent, selective, and orally active leukotriene a4 hydrolase inhibitor with anti-inflammatory activity. J Med Chem. 2008 Jul 24;51(14):4150-69. DMZH0K8 RU https://pubmed.ncbi.nlm.nih.gov/18588282 DMZ8M0K DI DMZ8M0K DMZ8M0K DN JNJ-10397049 DMZ8M0K MI TT9N02I DMZ8M0K MN Orexin receptor type 2 (HCRTR2) DMZ8M0K MT DTT DMZ8M0K MA Modulator DMZ8M0K RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 322). DMZ8M0K RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=322 DMXNFU5 DI DMXNFU5 DMXNFU5 DN JNJ-16567083 DMXNFU5 MI TTVBPDM DMXNFU5 MN Metabotropic glutamate receptor 1 (mGluR1) DMXNFU5 MT DTT DMXNFU5 MA Modulator (allosteric modulator) DMXNFU5 RN A positron emission tomography radioligand for the in vivo labeling of metabotropic glutamate 1 receptor: (3-ethyl-2-[11C]methyl-6-quinolinyl)(cis- 4-methoxycyclohexyl)methanone. J Med Chem. 2005 Aug11;48(16):5096-9. DMXNFU5 RU https://pubmed.ncbi.nlm.nih.gov/16078827 DM3ZNF9 DI DM3ZNF9 DM3ZNF9 DN JNJ-1661010 DM3ZNF9 MI TTDP1UC DM3ZNF9 MN Fatty acid amide hydrolase (FAAH) DM3ZNF9 MT DTT DM3ZNF9 MA Inhibitor DM3ZNF9 RN Thiadiazolopiperazinyl ureas as inhibitors of fatty acid amide hydrolase. Bioorg Med Chem Lett. 2008 Sep 1;18(17):4838-43. DM3ZNF9 RU https://pubmed.ncbi.nlm.nih.gov/18693015 DMJ1DE9 DI DMJ1DE9 DMJ1DE9 DN JNJ-17148066 DMJ1DE9 MI TTZAYWL DMJ1DE9 MN Estrogen receptor (ESR) DMJ1DE9 MT DTT DMJ1DE9 MA Inhibitor DMJ1DE9 RN Identification and structure-activity relationships of chromene-derived selective estrogen receptor modulators for treatment of postmenopausal symp... J Med Chem. 2009 Dec 10;52(23):7544-69. DMJ1DE9 RU https://pubmed.ncbi.nlm.nih.gov/19366247 DMIXUNB DI DMIXUNB DMIXUNB DN JNJ-17156516 DMIXUNB MI TTCG0AL DMIXUNB MN Cholecystokinin receptor type A (CCKAR) DMIXUNB MT DTT DMIXUNB MA Antagonist DMIXUNB RN 3-[5-(3,4-Dichloro-phenyl)-1-(4-methoxy-phenyl)-1H-pyrazol-3-yl]-2-m-tolyl-propionate (JNJ-17156516), a novel, potent, and selective cholecystokini... J Pharmacol Exp Ther. 2007 Nov;323(2):562-9. DMIXUNB RU https://pubmed.ncbi.nlm.nih.gov/17684117 DMDUWBF DI DMDUWBF DMDUWBF DN JNJ-17203212 DMDUWBF MI TTMI6F5 DMDUWBF MN Transient receptor potential cation channel V1 (TRPV1) DMDUWBF MT DTT DMDUWBF MA Inhibitor DMDUWBF RN The potential of transient receptor potential vanilloid type 1 channel modulators for the treatment of pain. J Med Chem. 2007 May 31;50(11):2589-96. DMDUWBF RU https://pubmed.ncbi.nlm.nih.gov/17489570 DMKH9O7 DI DMKH9O7 DMKH9O7 DN JNJ-1930942 DMKH9O7 MI TTLA931 DMKH9O7 MN Neuronal acetylcholine receptor alpha-7 (CHRNA7) DMKH9O7 MT DTT DMKH9O7 MA Modulator DMKH9O7 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 468). DMKH9O7 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=468 DM94IJC DI DM94IJC DM94IJC DN JNJ-19398990 DM94IJC MI TTZAYWL DM94IJC MN Estrogen receptor (ESR) DM94IJC MT DTT DM94IJC MA Inhibitor DM94IJC RN Identification and structure-activity relationships of chromene-derived selective estrogen receptor modulators for treatment of postmenopausal symp... J Med Chem. 2009 Dec 10;52(23):7544-69. DM94IJC RU https://pubmed.ncbi.nlm.nih.gov/19366247 DMK6TVN DI DMK6TVN DMK6TVN DN JNJ-26529126 DMK6TVN MI TTZAYWL DMK6TVN MN Estrogen receptor (ESR) DMK6TVN MT DTT DMK6TVN MA Inhibitor DMK6TVN RN Identification and structure-activity relationships of chromene-derived selective estrogen receptor modulators for treatment of postmenopausal symp... J Med Chem. 2009 Dec 10;52(23):7544-69. DMK6TVN RU https://pubmed.ncbi.nlm.nih.gov/19366247 DMBZ7MA DI DMBZ7MA DMBZ7MA DN JNJ-26529152 DMBZ7MA MI TTZAYWL DMBZ7MA MN Estrogen receptor (ESR) DMBZ7MA MT DTT DMBZ7MA MA Inhibitor DMBZ7MA RN Identification and structure-activity relationships of chromene-derived selective estrogen receptor modulators for treatment of postmenopausal symp... J Med Chem. 2009 Dec 10;52(23):7544-69. DMBZ7MA RU https://pubmed.ncbi.nlm.nih.gov/19366247 DMCMH7O DI DMCMH7O DMCMH7O DN JNJ-28312141 DMCMH7O MI TTVW6QL DMCMH7O MN CSF1R messenger RNA (CSF1R mRNA) DMCMH7O MT DTT DMCMH7O MA Inhibitor DMCMH7O RN Comprehensive analysis of kinase inhibitor selectivity. Nat Biotechnol. 2011 Oct 30;29(11):1046-51. DMCMH7O RU https://pubmed.ncbi.nlm.nih.gov/22037378 DMCMH7O DI DMCMH7O DMCMH7O DN JNJ-28312141 DMCMH7O MI TTGJCWZ DMCMH7O MN Fms-like tyrosine kinase 3 (FLT-3) DMCMH7O MT DTT DMCMH7O MA Inhibitor DMCMH7O RN JNJ-28312141, a novel orally active colony-stimulating factor-1 receptor/FMS-related receptor tyrosine kinase-3 receptor tyrosine kinase inhibitor with potential utility in solid tumors, bone metastases, and acute myeloid leukemia. Mol Cancer Ther. 2009 Nov;8(11):3151-61. DMCMH7O RU https://pubmed.ncbi.nlm.nih.gov/19887542 DMCMH7O DI DMCMH7O DMCMH7O DN JNJ-28312141 DMCMH7O MI TT860QF DMCMH7O MN LCK tyrosine protein kinase (LCK) DMCMH7O MT DTT DMCMH7O MA Inhibitor DMCMH7O RN JNJ-28312141, a novel orally active colony-stimulating factor-1 receptor/FMS-related receptor tyrosine kinase-3 receptor tyrosine kinase inhibitor with potential utility in solid tumors, bone metastases, and acute myeloid leukemia. Mol Cancer Ther. 2009 Nov;8(11):3151-61. DMCMH7O RU https://pubmed.ncbi.nlm.nih.gov/19887542 DMCMH7O DI DMCMH7O DMCMH7O DN JNJ-28312141 DMCMH7O MI TTXABCW DMCMH7O MN NT-3 growth factor receptor (TrkC) DMCMH7O MT DTT DMCMH7O MA Inhibitor DMCMH7O RN JNJ-28312141, a novel orally active colony-stimulating factor-1 receptor/FMS-related receptor tyrosine kinase-3 receptor tyrosine kinase inhibitor with potential utility in solid tumors, bone metastases, and acute myeloid leukemia. Mol Cancer Ther. 2009 Nov;8(11):3151-61. DMCMH7O RU https://pubmed.ncbi.nlm.nih.gov/19887542 DMCMH7O DI DMCMH7O DMCMH7O DN JNJ-28312141 DMCMH7O MI TTX41N9 DMCMH7O MN Tyrosine-protein kinase Kit (KIT) DMCMH7O MT DTT DMCMH7O MA Inhibitor DMCMH7O RN JNJ-28312141, a novel orally active colony-stimulating factor-1 receptor/FMS-related receptor tyrosine kinase-3 receptor tyrosine kinase inhibitor with potential utility in solid tumors, bone metastases, and acute myeloid leukemia. Mol Cancer Ther. 2009 Nov;8(11):3151-61. DMCMH7O RU https://pubmed.ncbi.nlm.nih.gov/19887542 DM84PWI DI DM84PWI DM84PWI DN JNJ-28318706 DM84PWI MI TTW5UDX DM84PWI MN Urotensin II receptor (UTS2R) DM84PWI MT DTT DM84PWI MA Inhibitor DM84PWI RN Nonpeptide urotensin-II receptor antagonists: a new ligand class based on piperazino-phthalimide and piperazino-isoindolinone subunits. J Med Chem. 2009 Dec 10;52(23):7432-45. DM84PWI RU https://pubmed.ncbi.nlm.nih.gov/19731961 DM5LEOR DI DM5LEOR DM5LEOR DN JNJ-28583867 DM5LEOR MI TT9JNIC DM5LEOR MN Histamine H3 receptor (H3R) DM5LEOR MT DTT DM5LEOR MA Inhibitor DM5LEOR RN Synthesis and biological activity of piperazine and diazepane amides that are histamine H3 antagonists and serotonin reuptake inhibitors. Bioorg Med Chem Lett. 2008 Jan 1;18(1):39-43. DM5LEOR RU https://pubmed.ncbi.nlm.nih.gov/18060777 DM5LEOR DI DM5LEOR DM5LEOR DN JNJ-28583867 DM5LEOR MI TT3ROYC DM5LEOR MN Serotonin transporter (SERT) DM5LEOR MT DTT DM5LEOR MA Inhibitor DM5LEOR RN Synthesis and biological activity of piperazine and diazepane amides that are histamine H3 antagonists and serotonin reuptake inhibitors. Bioorg Med Chem Lett. 2008 Jan 1;18(1):39-43. DM5LEOR RU https://pubmed.ncbi.nlm.nih.gov/18060777 DM48Y9E DI DM48Y9E DM48Y9E DN JNJ-38158471 DM48Y9E MI TTUTJGQ DM48Y9E MN Vascular endothelial growth factor receptor 2 (KDR) DM48Y9E MT DTT DM48Y9E MA Inhibitor DM48Y9E RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1813). DM48Y9E RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1813 DMLOQ92 DI DMLOQ92 DMLOQ92 DN JNJ-42153605 DMLOQ92 MI TTXJ47W DMLOQ92 MN Metabotropic glutamate receptor 2 (mGluR2) DMLOQ92 MT DTT DMLOQ92 MA Modulator (allosteric modulator) DMLOQ92 RN Discovery of 3-cyclopropylmethyl-7-(4-phenylpiperidin-1-yl)-8-trifluoromethyl[1,2,4]triazolo[4,3-a]pyridine (JNJ-42153605): a positive allosteric modulator of the metabotropic glutamate 2 receptor. JMed Chem. 2012 Oct 25;55(20):8770-89. DMLOQ92 RU https://pubmed.ncbi.nlm.nih.gov/23072213 DMWYU5C DI DMWYU5C DMWYU5C DN JNJ-5207787 DMWYU5C MI TTJ6WK9 DMWYU5C MN Neuropeptide Y receptor type 2 (NPY2R) DMWYU5C MT DTT DMWYU5C MA Antagonist DMWYU5C RN Characterization of N-(1-Acetyl-2,3-dihydro-1H-indol-6-yl)-3-(3-cyano-phenyl)-N-[1-(2-cyclopentyl-ethyl)-piperidin-4yl]acrylamide (JNJ-5207787), a ... J Pharmacol Exp Ther. 2004 Mar;308(3):1130-7. DMWYU5C RU https://pubmed.ncbi.nlm.nih.gov/14617685 DM5L23N DI DM5L23N DM5L23N DN JNJ-5207852 DM5L23N MI TT9JNIC DM5L23N MN Histamine H3 receptor (H3R) DM5L23N MT DTT DM5L23N MA Antagonist DM5L23N RN The histamine H3 receptor: from gene cloning to H3 receptor drugs. Nat Rev Drug Discov. 2005 Feb;4(2):107-20. DM5L23N RU https://pubmed.ncbi.nlm.nih.gov/15665857 DMHTYBS DI DMHTYBS DMHTYBS DN JNJ-7706621 DMHTYBS MI DTI7UX6 DMHTYBS MN Breast cancer resistance protein (ABCG2) DMHTYBS MT DTP DMHTYBS MA Substrate DMHTYBS RN Role of the ABCG2 drug transporter in the resistance and oral bioavailability of a potent cyclin-dependent kinase/Aurora kinase inhibitor. Mol Cancer Ther. 2006 Oct;5(10):2459-67. DMHTYBS RU https://doi.org/10.1158/1535-7163.MCT-06-0339 DMHTYBS DI DMHTYBS DMHTYBS DN JNJ-7706621 DMHTYBS MI TTH6V3D DMHTYBS MN Cyclin-dependent kinase 1 (CDK1) DMHTYBS MT DTT DMHTYBS MA Inhibitor DMHTYBS RN Synthesis and evaluation of N-acyl sulfonamides as potential prodrugs of cyclin-dependent kinase inhibitor JNJ-7706621. Bioorg Med Chem Lett. 2006 Jul 15;16(14):3639-41. DMHTYBS RU https://pubmed.ncbi.nlm.nih.gov/16682186 DMHTYBS DI DMHTYBS DMHTYBS DN JNJ-7706621 DMHTYBS MI TT7HF4W DMHTYBS MN Cyclin-dependent kinase 2 (CDK2) DMHTYBS MT DTT DMHTYBS MA Inhibitor DMHTYBS RN Synthesis and evaluation of N-acyl sulfonamides as potential prodrugs of cyclin-dependent kinase inhibitor JNJ-7706621. Bioorg Med Chem Lett. 2006 Jul 15;16(14):3639-41. DMHTYBS RU https://pubmed.ncbi.nlm.nih.gov/16682186 DMLWYJB DI DMLWYJB DMLWYJB DN JNK-IN-8 DMLWYJB MI TT3IVG2 DMLWYJB MN JNK2 messenger RNA (JNK2 mRNA) DMLWYJB MT DTT DMLWYJB MA Inhibitor DMLWYJB RN Discovery of potent and selective covalent inhibitors of JNK. Chem Biol. 2012 Jan 27;19(1):140-54. DMLWYJB RU https://pubmed.ncbi.nlm.nih.gov/22284361 DMLWYJB DI DMLWYJB DMLWYJB DN JNK-IN-8 DMLWYJB MI TT0K6EO DMLWYJB MN Stress-activated protein kinase JNK1 (JNK1) DMLWYJB MT DTT DMLWYJB MA Inhibitor DMLWYJB RN Discovery of potent and selective covalent inhibitors of JNK. Chem Biol. 2012 Jan 27;19(1):140-54. DMLWYJB RU https://pubmed.ncbi.nlm.nih.gov/22284361 DMLWYJB DI DMLWYJB DMLWYJB DN JNK-IN-8 DMLWYJB MI TT056SO DMLWYJB MN Stress-activated protein kinase JNK3 (JNK3) DMLWYJB MT DTT DMLWYJB MA Inhibitor DMLWYJB RN Discovery of potent and selective covalent inhibitors of JNK. Chem Biol. 2012 Jan 27;19(1):140-54. DMLWYJB RU https://pubmed.ncbi.nlm.nih.gov/22284361 DMYBJ4K DI DMYBJ4K DMYBJ4K DN joro toxin DMYBJ4K MI TTVPQTF DMYBJ4K MN Glutamate receptor AMPA 1 (GRIA1) DMYBJ4K MT DTT DMYBJ4K MA Blocker (channel blocker) DMYBJ4K RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 444). DMYBJ4K RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=444 DMYBJ4K DI DMYBJ4K DMYBJ4K DN joro toxin DMYBJ4K MI TT82EZV DMYBJ4K MN Glutamate receptor AMPA 3 (GRIA3) DMYBJ4K MT DTT DMYBJ4K MA Blocker (channel blocker) DMYBJ4K RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 446). DMYBJ4K RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=446 DMYBJ4K DI DMYBJ4K DMYBJ4K DN joro toxin DMYBJ4K MI TTPJR0G DMYBJ4K MN Glutamate receptor AMPA 4 (GRIA4) DMYBJ4K MT DTT DMYBJ4K MA Blocker (channel blocker) DMYBJ4K RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 447). DMYBJ4K RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=447 DMMVBK6 DI DMMVBK6 DMMVBK6 DN JP1302 DMMVBK6 MI TTWG9A4 DMMVBK6 MN Adrenergic receptor alpha-2A (ADRA2A) DMMVBK6 MT DTT DMMVBK6 MA Inhibitor DMMVBK6 RN Structure-activity relationship of quinoline derivatives as potent and selective alpha(2C)-adrenoceptor antagonists. J Med Chem. 2006 Oct 19;49(21):6351-63. DMMVBK6 RU https://pubmed.ncbi.nlm.nih.gov/17034141 DMMVBK6 DI DMMVBK6 DMMVBK6 DN JP1302 DMMVBK6 MI TTWM4TY DMMVBK6 MN Adrenergic receptor alpha-2B (ADRA2B) DMMVBK6 MT DTT DMMVBK6 MA Inhibitor DMMVBK6 RN Structure-activity relationship of quinoline derivatives as potent and selective alpha(2C)-adrenoceptor antagonists. J Med Chem. 2006 Oct 19;49(21):6351-63. DMMVBK6 RU https://pubmed.ncbi.nlm.nih.gov/17034141 DMMVBK6 DI DMMVBK6 DMMVBK6 DN JP1302 DMMVBK6 MI TT2NUT5 DMMVBK6 MN Adrenergic receptor alpha-2C (ADRA2C) DMMVBK6 MT DTT DMMVBK6 MA Antagonist DMMVBK6 RN Pharmacological characterization and CNS effects of a novel highly selective alpha2C-adrenoceptor antagonist JP-1302. Br J Pharmacol. 2007 Feb;150(4):391-402. DMMVBK6 RU https://pubmed.ncbi.nlm.nih.gov/17220913 DM3XQDH DI DM3XQDH DM3XQDH DN JQ1 DM3XQDH MI TTNISW6 DM3XQDH MN HUMAN bromodomain-containing protein 2 (BRD2) DM3XQDH MT DTT DM3XQDH MA Inhibitor DM3XQDH RN Uncovering the Role of BRD2 in COVID-19. 2020-03-19 DM3XQDH RU https://www.caymanchem.com/news/uncovering-the-role-of-brd2-in-covid-19 DMD9W0B DI DMD9W0B DMD9W0B DN JT-2724 DMD9W0B MI TTB2MXP DMD9W0B MN Angiotensinogenase renin (REN) DMD9W0B MT DTT DMD9W0B MA Modulator DMD9W0B RN The ChEMBL database in 2017. Nucleic Acids Res. 2017 Jan 4;45(D1):D945-D954. DMD9W0B RU https://www.ncbi.nlm.nih.gov/pubmed/27899562 DMXZ9RF DI DMXZ9RF DMXZ9RF DN JWB-1-84-1 DMXZ9RF MI TTH18TF DMXZ9RF MN Muscarinic acetylcholine receptor M5 (CHRM5) DMXZ9RF MT DTT DMXZ9RF MA Modulator DMXZ9RF RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 467). DMXZ9RF RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=467 DMYX30S DI DMYX30S DMYX30S DN JWH-051 DMYX30S MI TTMSFAW DMYX30S MN Cannabinoid receptor 2 (CB2) DMYX30S MT DTT DMYX30S MA Agonist DMYX30S RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 57). DMYX30S RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=57 DM7JQDS DI DM7JQDS DM7JQDS DN JWH-120 DM7JQDS MI TT6OEDT DM7JQDS MN Cannabinoid receptor 1 (CB1) DM7JQDS MT DTT DM7JQDS MA Inhibitor DM7JQDS RN Discovery of novel CB2 receptor ligands by a pharmacophore-based virtual screening workflow. J Med Chem. 2009 Jan 22;52(2):369-78. DM7JQDS RU https://pubmed.ncbi.nlm.nih.gov/19143566 DM7JQDS DI DM7JQDS DM7JQDS DN JWH-120 DM7JQDS MI TTMSFAW DM7JQDS MN Cannabinoid receptor 2 (CB2) DM7JQDS MT DTT DM7JQDS MA Inhibitor DM7JQDS RN Discovery of novel CB2 receptor ligands by a pharmacophore-based virtual screening workflow. J Med Chem. 2009 Jan 22;52(2):369-78. DM7JQDS RU https://pubmed.ncbi.nlm.nih.gov/19143566 DM1DEYU DI DM1DEYU DM1DEYU DN JWH-133 DM1DEYU MI TT6OEDT DM1DEYU MN Cannabinoid receptor 1 (CB1) DM1DEYU MT DTT DM1DEYU MA Inhibitor DM1DEYU RN 1-Bromo-3-(1',1'-dimethylalkyl)-1-deoxy-(8)-tetrahydrocannabinols: New selective ligands for the cannabinoid CB(2) receptor. Bioorg Med Chem. 2010 Nov 15;18(22):7809-15. DM1DEYU RU https://pubmed.ncbi.nlm.nih.gov/20943404 DM1DEYU DI DM1DEYU DM1DEYU DN JWH-133 DM1DEYU MI TTMSFAW DM1DEYU MN Cannabinoid receptor 2 (CB2) DM1DEYU MT DTT DM1DEYU MA Inhibitor DM1DEYU RN Design, synthesis, and biological evaluation of new 1,8-naphthyridin-4(1H)-on-3-carboxamide and quinolin-4(1H)-on-3-carboxamide derivatives as CB2 ... J Med Chem. 2006 Oct 5;49(20):5947-57. DM1DEYU RU https://pubmed.ncbi.nlm.nih.gov/17004710 DMZQ31O DI DMZQ31O DMZQ31O DN JWH-145 DMZQ31O MI TT6OEDT DMZQ31O MN Cannabinoid receptor 1 (CB1) DMZQ31O MT DTT DMZQ31O MA Inhibitor DMZQ31O RN 1-Alkyl-2-aryl-4-(1-naphthoyl)pyrroles: new high affinity ligands for the cannabinoid CB1 and CB2 receptors. Bioorg Med Chem Lett. 2006 Oct 15;16(20):5432-5. DMZQ31O RU https://pubmed.ncbi.nlm.nih.gov/16889960 DMZQ31O DI DMZQ31O DMZQ31O DN JWH-145 DMZQ31O MI TTMSFAW DMZQ31O MN Cannabinoid receptor 2 (CB2) DMZQ31O MT DTT DMZQ31O MA Inhibitor DMZQ31O RN 1-Alkyl-2-aryl-4-(1-naphthoyl)pyrroles: new high affinity ligands for the cannabinoid CB1 and CB2 receptors. Bioorg Med Chem Lett. 2006 Oct 15;16(20):5432-5. DMZQ31O RU https://pubmed.ncbi.nlm.nih.gov/16889960 DMU7E6A DI DMU7E6A DMU7E6A DN JWH-146 DMU7E6A MI TT6OEDT DMU7E6A MN Cannabinoid receptor 1 (CB1) DMU7E6A MT DTT DMU7E6A MA Inhibitor DMU7E6A RN 1-Alkyl-2-aryl-4-(1-naphthoyl)pyrroles: new high affinity ligands for the cannabinoid CB1 and CB2 receptors. Bioorg Med Chem Lett. 2006 Oct 15;16(20):5432-5. DMU7E6A RU https://pubmed.ncbi.nlm.nih.gov/16889960 DMU7E6A DI DMU7E6A DMU7E6A DN JWH-146 DMU7E6A MI TTMSFAW DMU7E6A MN Cannabinoid receptor 2 (CB2) DMU7E6A MT DTT DMU7E6A MA Inhibitor DMU7E6A RN 1-Alkyl-2-aryl-4-(1-naphthoyl)pyrroles: new high affinity ligands for the cannabinoid CB1 and CB2 receptors. Bioorg Med Chem Lett. 2006 Oct 15;16(20):5432-5. DMU7E6A RU https://pubmed.ncbi.nlm.nih.gov/16889960 DMEX9GV DI DMEX9GV DMEX9GV DN JWH-147 DMEX9GV MI TT6OEDT DMEX9GV MN Cannabinoid receptor 1 (CB1) DMEX9GV MT DTT DMEX9GV MA Inhibitor DMEX9GV RN 1-Alkyl-2-aryl-4-(1-naphthoyl)pyrroles: new high affinity ligands for the cannabinoid CB1 and CB2 receptors. Bioorg Med Chem Lett. 2006 Oct 15;16(20):5432-5. DMEX9GV RU https://pubmed.ncbi.nlm.nih.gov/16889960 DMEX9GV DI DMEX9GV DMEX9GV DN JWH-147 DMEX9GV MI TTMSFAW DMEX9GV MN Cannabinoid receptor 2 (CB2) DMEX9GV MT DTT DMEX9GV MA Inhibitor DMEX9GV RN 1-Alkyl-2-aryl-4-(1-naphthoyl)pyrroles: new high affinity ligands for the cannabinoid CB1 and CB2 receptors. Bioorg Med Chem Lett. 2006 Oct 15;16(20):5432-5. DMEX9GV RU https://pubmed.ncbi.nlm.nih.gov/16889960 DM86OZD DI DM86OZD DM86OZD DN JWH-150 DM86OZD MI TT6OEDT DM86OZD MN Cannabinoid receptor 1 (CB1) DM86OZD MT DTT DM86OZD MA Inhibitor DM86OZD RN 1-Alkyl-2-aryl-4-(1-naphthoyl)pyrroles: new high affinity ligands for the cannabinoid CB1 and CB2 receptors. Bioorg Med Chem Lett. 2006 Oct 15;16(20):5432-5. DM86OZD RU https://pubmed.ncbi.nlm.nih.gov/16889960 DM86OZD DI DM86OZD DM86OZD DN JWH-150 DM86OZD MI TTMSFAW DM86OZD MN Cannabinoid receptor 2 (CB2) DM86OZD MT DTT DM86OZD MA Inhibitor DM86OZD RN 1-Alkyl-2-aryl-4-(1-naphthoyl)pyrroles: new high affinity ligands for the cannabinoid CB1 and CB2 receptors. Bioorg Med Chem Lett. 2006 Oct 15;16(20):5432-5. DM86OZD RU https://pubmed.ncbi.nlm.nih.gov/16889960 DMGPN61 DI DMGPN61 DMGPN61 DN JWH-151 DMGPN61 MI TTMSFAW DMGPN61 MN Cannabinoid receptor 2 (CB2) DMGPN61 MT DTT DMGPN61 MA Inhibitor DMGPN61 RN Discovery of novel CB2 receptor ligands by a pharmacophore-based virtual screening workflow. J Med Chem. 2009 Jan 22;52(2):369-78. DMGPN61 RU https://pubmed.ncbi.nlm.nih.gov/19143566 DMWGSQO DI DMWGSQO DMWGSQO DN JWH-156 DMWGSQO MI TT6OEDT DMWGSQO MN Cannabinoid receptor 1 (CB1) DMWGSQO MT DTT DMWGSQO MA Inhibitor DMWGSQO RN 1-Alkyl-2-aryl-4-(1-naphthoyl)pyrroles: new high affinity ligands for the cannabinoid CB1 and CB2 receptors. Bioorg Med Chem Lett. 2006 Oct 15;16(20):5432-5. DMWGSQO RU https://pubmed.ncbi.nlm.nih.gov/16889960 DMWGSQO DI DMWGSQO DMWGSQO DN JWH-156 DMWGSQO MI TTMSFAW DMWGSQO MN Cannabinoid receptor 2 (CB2) DMWGSQO MT DTT DMWGSQO MA Inhibitor DMWGSQO RN 1-Alkyl-2-aryl-4-(1-naphthoyl)pyrroles: new high affinity ligands for the cannabinoid CB1 and CB2 receptors. Bioorg Med Chem Lett. 2006 Oct 15;16(20):5432-5. DMWGSQO RU https://pubmed.ncbi.nlm.nih.gov/16889960 DMLDOYV DI DMLDOYV DMLDOYV DN JWH-167 DMLDOYV MI TTMSFAW DMLDOYV MN Cannabinoid receptor 2 (CB2) DMLDOYV MT DTT DMLDOYV MA Inhibitor DMLDOYV RN 1-Pentyl-3-phenylacetylindoles, a new class of cannabimimetic indoles. Bioorg Med Chem Lett. 2005 Sep 15;15(18):4110-3. DMLDOYV RU https://pubmed.ncbi.nlm.nih.gov/16005223 DMC2XSU DI DMC2XSU DMC2XSU DN JWH-201 DMC2XSU MI TTMSFAW DMC2XSU MN Cannabinoid receptor 2 (CB2) DMC2XSU MT DTT DMC2XSU MA Inhibitor DMC2XSU RN 1-Pentyl-3-phenylacetylindoles, a new class of cannabimimetic indoles. Bioorg Med Chem Lett. 2005 Sep 15;15(18):4110-3. DMC2XSU RU https://pubmed.ncbi.nlm.nih.gov/16005223 DMQU2SV DI DMQU2SV DMQU2SV DN JWH-202 DMQU2SV MI TTMSFAW DMQU2SV MN Cannabinoid receptor 2 (CB2) DMQU2SV MT DTT DMQU2SV MA Inhibitor DMQU2SV RN 1-Pentyl-3-phenylacetylindoles, a new class of cannabimimetic indoles. Bioorg Med Chem Lett. 2005 Sep 15;15(18):4110-3. DMQU2SV RU https://pubmed.ncbi.nlm.nih.gov/16005223 DMEJ8YA DI DMEJ8YA DMEJ8YA DN JWH-203 DMEJ8YA MI TTMSFAW DMEJ8YA MN Cannabinoid receptor 2 (CB2) DMEJ8YA MT DTT DMEJ8YA MA Inhibitor DMEJ8YA RN 1-Pentyl-3-phenylacetylindoles, a new class of cannabimimetic indoles. Bioorg Med Chem Lett. 2005 Sep 15;15(18):4110-3. DMEJ8YA RU https://pubmed.ncbi.nlm.nih.gov/16005223 DMDTILC DI DMDTILC DMDTILC DN JWH-204 DMDTILC MI TTMSFAW DMDTILC MN Cannabinoid receptor 2 (CB2) DMDTILC MT DTT DMDTILC MA Inhibitor DMDTILC RN 1-Pentyl-3-phenylacetylindoles, a new class of cannabimimetic indoles. Bioorg Med Chem Lett. 2005 Sep 15;15(18):4110-3. DMDTILC RU https://pubmed.ncbi.nlm.nih.gov/16005223 DMKIR63 DI DMKIR63 DMKIR63 DN JWH-205 DMKIR63 MI TTMSFAW DMKIR63 MN Cannabinoid receptor 2 (CB2) DMKIR63 MT DTT DMKIR63 MA Inhibitor DMKIR63 RN 1-Pentyl-3-phenylacetylindoles, a new class of cannabimimetic indoles. Bioorg Med Chem Lett. 2005 Sep 15;15(18):4110-3. DMKIR63 RU https://pubmed.ncbi.nlm.nih.gov/16005223 DMGFSQB DI DMGFSQB DMGFSQB DN JWH-206 DMGFSQB MI TTMSFAW DMGFSQB MN Cannabinoid receptor 2 (CB2) DMGFSQB MT DTT DMGFSQB MA Inhibitor DMGFSQB RN 1-Pentyl-3-phenylacetylindoles, a new class of cannabimimetic indoles. Bioorg Med Chem Lett. 2005 Sep 15;15(18):4110-3. DMGFSQB RU https://pubmed.ncbi.nlm.nih.gov/16005223 DMF70IM DI DMF70IM DMF70IM DN JWH-207 DMF70IM MI TTMSFAW DMF70IM MN Cannabinoid receptor 2 (CB2) DMF70IM MT DTT DMF70IM MA Inhibitor DMF70IM RN 1-Pentyl-3-phenylacetylindoles, a new class of cannabimimetic indoles. Bioorg Med Chem Lett. 2005 Sep 15;15(18):4110-3. DMF70IM RU https://pubmed.ncbi.nlm.nih.gov/16005223 DMLYHUN DI DMLYHUN DMLYHUN DN JWH-208 DMLYHUN MI TTMSFAW DMLYHUN MN Cannabinoid receptor 2 (CB2) DMLYHUN MT DTT DMLYHUN MA Inhibitor DMLYHUN RN 1-Pentyl-3-phenylacetylindoles, a new class of cannabimimetic indoles. Bioorg Med Chem Lett. 2005 Sep 15;15(18):4110-3. DMLYHUN RU https://pubmed.ncbi.nlm.nih.gov/16005223 DMDXCIV DI DMDXCIV DMDXCIV DN JWH-209 DMDXCIV MI TTMSFAW DMDXCIV MN Cannabinoid receptor 2 (CB2) DMDXCIV MT DTT DMDXCIV MA Inhibitor DMDXCIV RN 1-Pentyl-3-phenylacetylindoles, a new class of cannabimimetic indoles. Bioorg Med Chem Lett. 2005 Sep 15;15(18):4110-3. DMDXCIV RU https://pubmed.ncbi.nlm.nih.gov/16005223 DMMKYGP DI DMMKYGP DMMKYGP DN JWH-229 DMMKYGP MI TT6OEDT DMMKYGP MN Cannabinoid receptor 1 (CB1) DMMKYGP MT DTT DMMKYGP MA Inhibitor DMMKYGP RN Discovery of novel CB2 receptor ligands by a pharmacophore-based virtual screening workflow. J Med Chem. 2009 Jan 22;52(2):369-78. DMMKYGP RU https://pubmed.ncbi.nlm.nih.gov/19143566 DMMKYGP DI DMMKYGP DMMKYGP DN JWH-229 DMMKYGP MI TTMSFAW DMMKYGP MN Cannabinoid receptor 2 (CB2) DMMKYGP MT DTT DMMKYGP MA Inhibitor DMMKYGP RN Discovery of novel CB2 receptor ligands by a pharmacophore-based virtual screening workflow. J Med Chem. 2009 Jan 22;52(2):369-78. DMMKYGP RU https://pubmed.ncbi.nlm.nih.gov/19143566 DMRQOL5 DI DMRQOL5 DMRQOL5 DN JWH-237 DMRQOL5 MI TTMSFAW DMRQOL5 MN Cannabinoid receptor 2 (CB2) DMRQOL5 MT DTT DMRQOL5 MA Inhibitor DMRQOL5 RN 1-Pentyl-3-phenylacetylindoles, a new class of cannabimimetic indoles. Bioorg Med Chem Lett. 2005 Sep 15;15(18):4110-3. DMRQOL5 RU https://pubmed.ncbi.nlm.nih.gov/16005223 DMGD73A DI DMGD73A DMGD73A DN JWH-243 DMGD73A MI TT6OEDT DMGD73A MN Cannabinoid receptor 1 (CB1) DMGD73A MT DTT DMGD73A MA Inhibitor DMGD73A RN 1-Alkyl-2-aryl-4-(1-naphthoyl)pyrroles: new high affinity ligands for the cannabinoid CB1 and CB2 receptors. Bioorg Med Chem Lett. 2006 Oct 15;16(20):5432-5. DMGD73A RU https://pubmed.ncbi.nlm.nih.gov/16889960 DMGD73A DI DMGD73A DMGD73A DN JWH-243 DMGD73A MI TTMSFAW DMGD73A MN Cannabinoid receptor 2 (CB2) DMGD73A MT DTT DMGD73A MA Inhibitor DMGD73A RN 1-Alkyl-2-aryl-4-(1-naphthoyl)pyrroles: new high affinity ligands for the cannabinoid CB1 and CB2 receptors. Bioorg Med Chem Lett. 2006 Oct 15;16(20):5432-5. DMGD73A RU https://pubmed.ncbi.nlm.nih.gov/16889960 DMETAOU DI DMETAOU DMETAOU DN JWH-244 DMETAOU MI TT6OEDT DMETAOU MN Cannabinoid receptor 1 (CB1) DMETAOU MT DTT DMETAOU MA Inhibitor DMETAOU RN 1-Alkyl-2-aryl-4-(1-naphthoyl)pyrroles: new high affinity ligands for the cannabinoid CB1 and CB2 receptors. Bioorg Med Chem Lett. 2006 Oct 15;16(20):5432-5. DMETAOU RU https://pubmed.ncbi.nlm.nih.gov/16889960 DMETAOU DI DMETAOU DMETAOU DN JWH-244 DMETAOU MI TTMSFAW DMETAOU MN Cannabinoid receptor 2 (CB2) DMETAOU MT DTT DMETAOU MA Inhibitor DMETAOU RN 1-Alkyl-2-aryl-4-(1-naphthoyl)pyrroles: new high affinity ligands for the cannabinoid CB1 and CB2 receptors. Bioorg Med Chem Lett. 2006 Oct 15;16(20):5432-5. DMETAOU RU https://pubmed.ncbi.nlm.nih.gov/16889960 DMC5RZ9 DI DMC5RZ9 DMC5RZ9 DN JWH-245 DMC5RZ9 MI TT6OEDT DMC5RZ9 MN Cannabinoid receptor 1 (CB1) DMC5RZ9 MT DTT DMC5RZ9 MA Inhibitor DMC5RZ9 RN 1-Alkyl-2-aryl-4-(1-naphthoyl)pyrroles: new high affinity ligands for the cannabinoid CB1 and CB2 receptors. Bioorg Med Chem Lett. 2006 Oct 15;16(20):5432-5. DMC5RZ9 RU https://pubmed.ncbi.nlm.nih.gov/16889960 DMC5RZ9 DI DMC5RZ9 DMC5RZ9 DN JWH-245 DMC5RZ9 MI TTMSFAW DMC5RZ9 MN Cannabinoid receptor 2 (CB2) DMC5RZ9 MT DTT DMC5RZ9 MA Inhibitor DMC5RZ9 RN 1-Alkyl-2-aryl-4-(1-naphthoyl)pyrroles: new high affinity ligands for the cannabinoid CB1 and CB2 receptors. Bioorg Med Chem Lett. 2006 Oct 15;16(20):5432-5. DMC5RZ9 RU https://pubmed.ncbi.nlm.nih.gov/16889960 DMGTEYB DI DMGTEYB DMGTEYB DN JWH-246 DMGTEYB MI TT6OEDT DMGTEYB MN Cannabinoid receptor 1 (CB1) DMGTEYB MT DTT DMGTEYB MA Inhibitor DMGTEYB RN 1-Alkyl-2-aryl-4-(1-naphthoyl)pyrroles: new high affinity ligands for the cannabinoid CB1 and CB2 receptors. Bioorg Med Chem Lett. 2006 Oct 15;16(20):5432-5. DMGTEYB RU https://pubmed.ncbi.nlm.nih.gov/16889960 DMGTEYB DI DMGTEYB DMGTEYB DN JWH-246 DMGTEYB MI TTMSFAW DMGTEYB MN Cannabinoid receptor 2 (CB2) DMGTEYB MT DTT DMGTEYB MA Inhibitor DMGTEYB RN 1-Alkyl-2-aryl-4-(1-naphthoyl)pyrroles: new high affinity ligands for the cannabinoid CB1 and CB2 receptors. Bioorg Med Chem Lett. 2006 Oct 15;16(20):5432-5. DMGTEYB RU https://pubmed.ncbi.nlm.nih.gov/16889960 DMURL8D DI DMURL8D DMURL8D DN JWH-248 DMURL8D MI TTMSFAW DMURL8D MN Cannabinoid receptor 2 (CB2) DMURL8D MT DTT DMURL8D MA Inhibitor DMURL8D RN 1-Pentyl-3-phenylacetylindoles, a new class of cannabimimetic indoles. Bioorg Med Chem Lett. 2005 Sep 15;15(18):4110-3. DMURL8D RU https://pubmed.ncbi.nlm.nih.gov/16005223 DMTOUCL DI DMTOUCL DMTOUCL DN JWH-249 DMTOUCL MI TTMSFAW DMTOUCL MN Cannabinoid receptor 2 (CB2) DMTOUCL MT DTT DMTOUCL MA Inhibitor DMTOUCL RN 1-Pentyl-3-phenylacetylindoles, a new class of cannabimimetic indoles. Bioorg Med Chem Lett. 2005 Sep 15;15(18):4110-3. DMTOUCL RU https://pubmed.ncbi.nlm.nih.gov/16005223 DMWVS5X DI DMWVS5X DMWVS5X DN JWH-250 DMWVS5X MI TTMSFAW DMWVS5X MN Cannabinoid receptor 2 (CB2) DMWVS5X MT DTT DMWVS5X MA Inhibitor DMWVS5X RN 1-Pentyl-3-phenylacetylindoles, a new class of cannabimimetic indoles. Bioorg Med Chem Lett. 2005 Sep 15;15(18):4110-3. DMWVS5X RU https://pubmed.ncbi.nlm.nih.gov/16005223 DMOJAUI DI DMOJAUI DMOJAUI DN JWH-251 DMOJAUI MI TTMSFAW DMOJAUI MN Cannabinoid receptor 2 (CB2) DMOJAUI MT DTT DMOJAUI MA Inhibitor DMOJAUI RN 1-Pentyl-3-phenylacetylindoles, a new class of cannabimimetic indoles. Bioorg Med Chem Lett. 2005 Sep 15;15(18):4110-3. DMOJAUI RU https://pubmed.ncbi.nlm.nih.gov/16005223 DM6IWCZ DI DM6IWCZ DM6IWCZ DN JWH-252 DM6IWCZ MI TTMSFAW DM6IWCZ MN Cannabinoid receptor 2 (CB2) DM6IWCZ MT DTT DM6IWCZ MA Inhibitor DM6IWCZ RN 1-Pentyl-3-phenylacetylindoles, a new class of cannabimimetic indoles. Bioorg Med Chem Lett. 2005 Sep 15;15(18):4110-3. DM6IWCZ RU https://pubmed.ncbi.nlm.nih.gov/16005223 DML1UMX DI DML1UMX DML1UMX DN JWH-253 DML1UMX MI TTMSFAW DML1UMX MN Cannabinoid receptor 2 (CB2) DML1UMX MT DTT DML1UMX MA Inhibitor DML1UMX RN 1-Pentyl-3-phenylacetylindoles, a new class of cannabimimetic indoles. Bioorg Med Chem Lett. 2005 Sep 15;15(18):4110-3. DML1UMX RU https://pubmed.ncbi.nlm.nih.gov/16005223 DM07XBG DI DM07XBG DM07XBG DN JWH-268 DM07XBG MI TT6OEDT DM07XBG MN Cannabinoid receptor 1 (CB1) DM07XBG MT DTT DM07XBG MA Inhibitor DM07XBG RN Discovery of novel CB2 receptor ligands by a pharmacophore-based virtual screening workflow. J Med Chem. 2009 Jan 22;52(2):369-78. DM07XBG RU https://pubmed.ncbi.nlm.nih.gov/19143566 DM07XBG DI DM07XBG DM07XBG DN JWH-268 DM07XBG MI TTMSFAW DM07XBG MN Cannabinoid receptor 2 (CB2) DM07XBG MT DTT DM07XBG MA Inhibitor DM07XBG RN Discovery of novel CB2 receptor ligands by a pharmacophore-based virtual screening workflow. J Med Chem. 2009 Jan 22;52(2):369-78. DM07XBG RU https://pubmed.ncbi.nlm.nih.gov/19143566 DM5FAUY DI DM5FAUY DM5FAUY DN JWH-292 DM5FAUY MI TT6OEDT DM5FAUY MN Cannabinoid receptor 1 (CB1) DM5FAUY MT DTT DM5FAUY MA Inhibitor DM5FAUY RN 1-Alkyl-2-aryl-4-(1-naphthoyl)pyrroles: new high affinity ligands for the cannabinoid CB1 and CB2 receptors. Bioorg Med Chem Lett. 2006 Oct 15;16(20):5432-5. DM5FAUY RU https://pubmed.ncbi.nlm.nih.gov/16889960 DM5FAUY DI DM5FAUY DM5FAUY DN JWH-292 DM5FAUY MI TTMSFAW DM5FAUY MN Cannabinoid receptor 2 (CB2) DM5FAUY MT DTT DM5FAUY MA Inhibitor DM5FAUY RN 1-Alkyl-2-aryl-4-(1-naphthoyl)pyrroles: new high affinity ligands for the cannabinoid CB1 and CB2 receptors. Bioorg Med Chem Lett. 2006 Oct 15;16(20):5432-5. DM5FAUY RU https://pubmed.ncbi.nlm.nih.gov/16889960 DMCK1XR DI DMCK1XR DMCK1XR DN JWH-293 DMCK1XR MI TT6OEDT DMCK1XR MN Cannabinoid receptor 1 (CB1) DMCK1XR MT DTT DMCK1XR MA Inhibitor DMCK1XR RN 1-Alkyl-2-aryl-4-(1-naphthoyl)pyrroles: new high affinity ligands for the cannabinoid CB1 and CB2 receptors. Bioorg Med Chem Lett. 2006 Oct 15;16(20):5432-5. DMCK1XR RU https://pubmed.ncbi.nlm.nih.gov/16889960 DMCK1XR DI DMCK1XR DMCK1XR DN JWH-293 DMCK1XR MI TTMSFAW DMCK1XR MN Cannabinoid receptor 2 (CB2) DMCK1XR MT DTT DMCK1XR MA Inhibitor DMCK1XR RN 1-Alkyl-2-aryl-4-(1-naphthoyl)pyrroles: new high affinity ligands for the cannabinoid CB1 and CB2 receptors. Bioorg Med Chem Lett. 2006 Oct 15;16(20):5432-5. DMCK1XR RU https://pubmed.ncbi.nlm.nih.gov/16889960 DMTMF8X DI DMTMF8X DMTMF8X DN JWH-294 DMTMF8X MI TTMSFAW DMTMF8X MN Cannabinoid receptor 2 (CB2) DMTMF8X MT DTT DMTMF8X MA Inhibitor DMTMF8X RN Synthesis and pharmacology of 1-deoxy analogs of CP-47,497 and CP-55,940. Bioorg Med Chem. 2008 Jan 1;16(1):322-35. DMTMF8X RU https://pubmed.ncbi.nlm.nih.gov/17919913 DMUMJGD DI DMUMJGD DMUMJGD DN JWH-295 DMUMJGD MI TTMSFAW DMUMJGD MN Cannabinoid receptor 2 (CB2) DMUMJGD MT DTT DMUMJGD MA Inhibitor DMUMJGD RN Synthesis and pharmacology of 1-deoxy analogs of CP-47,497 and CP-55,940. Bioorg Med Chem. 2008 Jan 1;16(1):322-35. DMUMJGD RU https://pubmed.ncbi.nlm.nih.gov/17919913 DMNRXJU DI DMNRXJU DMNRXJU DN JWH-296 DMNRXJU MI TTMSFAW DMNRXJU MN Cannabinoid receptor 2 (CB2) DMNRXJU MT DTT DMNRXJU MA Inhibitor DMNRXJU RN Synthesis and pharmacology of 1-deoxy analogs of CP-47,497 and CP-55,940. Bioorg Med Chem. 2008 Jan 1;16(1):322-35. DMNRXJU RU https://pubmed.ncbi.nlm.nih.gov/17919913 DM4A761 DI DM4A761 DM4A761 DN JWH-297 DM4A761 MI TT6OEDT DM4A761 MN Cannabinoid receptor 1 (CB1) DM4A761 MT DTT DM4A761 MA Inhibitor DM4A761 RN Synthesis and pharmacology of 1-deoxy analogs of CP-47,497 and CP-55,940. Bioorg Med Chem. 2008 Jan 1;16(1):322-35. DM4A761 RU https://pubmed.ncbi.nlm.nih.gov/17919913 DM4A761 DI DM4A761 DM4A761 DN JWH-297 DM4A761 MI TTMSFAW DM4A761 MN Cannabinoid receptor 2 (CB2) DM4A761 MT DTT DM4A761 MA Inhibitor DM4A761 RN Synthesis and pharmacology of 1-deoxy analogs of CP-47,497 and CP-55,940. Bioorg Med Chem. 2008 Jan 1;16(1):322-35. DM4A761 RU https://pubmed.ncbi.nlm.nih.gov/17919913 DMI7LF1 DI DMI7LF1 DMI7LF1 DN JWH-302 DMI7LF1 MI TTMSFAW DMI7LF1 MN Cannabinoid receptor 2 (CB2) DMI7LF1 MT DTT DMI7LF1 MA Inhibitor DMI7LF1 RN 1-Pentyl-3-phenylacetylindoles, a new class of cannabimimetic indoles. Bioorg Med Chem Lett. 2005 Sep 15;15(18):4110-3. DMI7LF1 RU https://pubmed.ncbi.nlm.nih.gov/16005223 DMCLAHR DI DMCLAHR DMCLAHR DN JWH-303 DMCLAHR MI TTMSFAW DMCLAHR MN Cannabinoid receptor 2 (CB2) DMCLAHR MT DTT DMCLAHR MA Inhibitor DMCLAHR RN 1-Pentyl-3-phenylacetylindoles, a new class of cannabimimetic indoles. Bioorg Med Chem Lett. 2005 Sep 15;15(18):4110-3. DMCLAHR RU https://pubmed.ncbi.nlm.nih.gov/16005223 DM36W9M DI DM36W9M DM36W9M DN JWH-305 DM36W9M MI TTMSFAW DM36W9M MN Cannabinoid receptor 2 (CB2) DM36W9M MT DTT DM36W9M MA Inhibitor DM36W9M RN 1-Pentyl-3-phenylacetylindoles, a new class of cannabimimetic indoles. Bioorg Med Chem Lett. 2005 Sep 15;15(18):4110-3. DM36W9M RU https://pubmed.ncbi.nlm.nih.gov/16005223 DMPDJKG DI DMPDJKG DMPDJKG DN JWH-306 DMPDJKG MI TTMSFAW DMPDJKG MN Cannabinoid receptor 2 (CB2) DMPDJKG MT DTT DMPDJKG MA Inhibitor DMPDJKG RN 1-Pentyl-3-phenylacetylindoles, a new class of cannabimimetic indoles. Bioorg Med Chem Lett. 2005 Sep 15;15(18):4110-3. DMPDJKG RU https://pubmed.ncbi.nlm.nih.gov/16005223 DM23RUZ DI DM23RUZ DM23RUZ DN JWH-307 DM23RUZ MI TT6OEDT DM23RUZ MN Cannabinoid receptor 1 (CB1) DM23RUZ MT DTT DM23RUZ MA Inhibitor DM23RUZ RN 1-Alkyl-2-aryl-4-(1-naphthoyl)pyrroles: new high affinity ligands for the cannabinoid CB1 and CB2 receptors. Bioorg Med Chem Lett. 2006 Oct 15;16(20):5432-5. DM23RUZ RU https://pubmed.ncbi.nlm.nih.gov/16889960 DM23RUZ DI DM23RUZ DM23RUZ DN JWH-307 DM23RUZ MI TTMSFAW DM23RUZ MN Cannabinoid receptor 2 (CB2) DM23RUZ MT DTT DM23RUZ MA Inhibitor DM23RUZ RN 1-Alkyl-2-aryl-4-(1-naphthoyl)pyrroles: new high affinity ligands for the cannabinoid CB1 and CB2 receptors. Bioorg Med Chem Lett. 2006 Oct 15;16(20):5432-5. DM23RUZ RU https://pubmed.ncbi.nlm.nih.gov/16889960 DMV5ASE DI DMV5ASE DMV5ASE DN JWH-308 DMV5ASE MI TT6OEDT DMV5ASE MN Cannabinoid receptor 1 (CB1) DMV5ASE MT DTT DMV5ASE MA Inhibitor DMV5ASE RN 1-Alkyl-2-aryl-4-(1-naphthoyl)pyrroles: new high affinity ligands for the cannabinoid CB1 and CB2 receptors. Bioorg Med Chem Lett. 2006 Oct 15;16(20):5432-5. DMV5ASE RU https://pubmed.ncbi.nlm.nih.gov/16889960 DMV5ASE DI DMV5ASE DMV5ASE DN JWH-308 DMV5ASE MI TTMSFAW DMV5ASE MN Cannabinoid receptor 2 (CB2) DMV5ASE MT DTT DMV5ASE MA Inhibitor DMV5ASE RN 1-Alkyl-2-aryl-4-(1-naphthoyl)pyrroles: new high affinity ligands for the cannabinoid CB1 and CB2 receptors. Bioorg Med Chem Lett. 2006 Oct 15;16(20):5432-5. DMV5ASE RU https://pubmed.ncbi.nlm.nih.gov/16889960 DMTV1B9 DI DMTV1B9 DMTV1B9 DN JWH-309 DMTV1B9 MI TT6OEDT DMTV1B9 MN Cannabinoid receptor 1 (CB1) DMTV1B9 MT DTT DMTV1B9 MA Inhibitor DMTV1B9 RN 1-Alkyl-2-aryl-4-(1-naphthoyl)pyrroles: new high affinity ligands for the cannabinoid CB1 and CB2 receptors. Bioorg Med Chem Lett. 2006 Oct 15;16(20):5432-5. DMTV1B9 RU https://pubmed.ncbi.nlm.nih.gov/16889960 DMTV1B9 DI DMTV1B9 DMTV1B9 DN JWH-309 DMTV1B9 MI TTMSFAW DMTV1B9 MN Cannabinoid receptor 2 (CB2) DMTV1B9 MT DTT DMTV1B9 MA Inhibitor DMTV1B9 RN 1-Alkyl-2-aryl-4-(1-naphthoyl)pyrroles: new high affinity ligands for the cannabinoid CB1 and CB2 receptors. Bioorg Med Chem Lett. 2006 Oct 15;16(20):5432-5. DMTV1B9 RU https://pubmed.ncbi.nlm.nih.gov/16889960 DMLABGW DI DMLABGW DMLABGW DN JWH-311 DMLABGW MI TTMSFAW DMLABGW MN Cannabinoid receptor 2 (CB2) DMLABGW MT DTT DMLABGW MA Inhibitor DMLABGW RN 1-Pentyl-3-phenylacetylindoles, a new class of cannabimimetic indoles. Bioorg Med Chem Lett. 2005 Sep 15;15(18):4110-3. DMLABGW RU https://pubmed.ncbi.nlm.nih.gov/16005223 DMYIGCU DI DMYIGCU DMYIGCU DN JWH-312 DMYIGCU MI TTMSFAW DMYIGCU MN Cannabinoid receptor 2 (CB2) DMYIGCU MT DTT DMYIGCU MA Inhibitor DMYIGCU RN 1-Pentyl-3-phenylacetylindoles, a new class of cannabimimetic indoles. Bioorg Med Chem Lett. 2005 Sep 15;15(18):4110-3. DMYIGCU RU https://pubmed.ncbi.nlm.nih.gov/16005223 DMWBHZL DI DMWBHZL DMWBHZL DN JWH-313 DMWBHZL MI TTMSFAW DMWBHZL MN Cannabinoid receptor 2 (CB2) DMWBHZL MT DTT DMWBHZL MA Inhibitor DMWBHZL RN 1-Pentyl-3-phenylacetylindoles, a new class of cannabimimetic indoles. Bioorg Med Chem Lett. 2005 Sep 15;15(18):4110-3. DMWBHZL RU https://pubmed.ncbi.nlm.nih.gov/16005223 DMCEKNJ DI DMCEKNJ DMCEKNJ DN JWH-314 DMCEKNJ MI TTMSFAW DMCEKNJ MN Cannabinoid receptor 2 (CB2) DMCEKNJ MT DTT DMCEKNJ MA Inhibitor DMCEKNJ RN 1-Pentyl-3-phenylacetylindoles, a new class of cannabimimetic indoles. Bioorg Med Chem Lett. 2005 Sep 15;15(18):4110-3. DMCEKNJ RU https://pubmed.ncbi.nlm.nih.gov/16005223 DMWHN56 DI DMWHN56 DMWHN56 DN JWH-315 DMWHN56 MI TTMSFAW DMWHN56 MN Cannabinoid receptor 2 (CB2) DMWHN56 MT DTT DMWHN56 MA Inhibitor DMWHN56 RN 1-Pentyl-3-phenylacetylindoles, a new class of cannabimimetic indoles. Bioorg Med Chem Lett. 2005 Sep 15;15(18):4110-3. DMWHN56 RU https://pubmed.ncbi.nlm.nih.gov/16005223 DM63LOX DI DM63LOX DM63LOX DN JWH-323 DM63LOX MI TTMSFAW DM63LOX MN Cannabinoid receptor 2 (CB2) DM63LOX MT DTT DM63LOX MA Inhibitor DM63LOX RN Synthesis and pharmacology of 1-deoxy analogs of CP-47,497 and CP-55,940. Bioorg Med Chem. 2008 Jan 1;16(1):322-35. DM63LOX RU https://pubmed.ncbi.nlm.nih.gov/17919913 DMJ2EI9 DI DMJ2EI9 DMJ2EI9 DN JWH-324 DMJ2EI9 MI TT6OEDT DMJ2EI9 MN Cannabinoid receptor 1 (CB1) DMJ2EI9 MT DTT DMJ2EI9 MA Inhibitor DMJ2EI9 RN Synthesis and pharmacology of 1-methoxy analogs of CP-47,497. Bioorg Med Chem. 2010 Aug 1;18(15):5475-82. DMJ2EI9 RU https://pubmed.ncbi.nlm.nih.gov/20621488 DMJ2EI9 DI DMJ2EI9 DMJ2EI9 DN JWH-324 DMJ2EI9 MI TTMSFAW DMJ2EI9 MN Cannabinoid receptor 2 (CB2) DMJ2EI9 MT DTT DMJ2EI9 MA Inhibitor DMJ2EI9 RN Synthesis and pharmacology of 1-methoxy analogs of CP-47,497. Bioorg Med Chem. 2010 Aug 1;18(15):5475-82. DMJ2EI9 RU https://pubmed.ncbi.nlm.nih.gov/20621488 DMHNTZ8 DI DMHNTZ8 DMHNTZ8 DN JWH-325 DMHNTZ8 MI TT6OEDT DMHNTZ8 MN Cannabinoid receptor 1 (CB1) DMHNTZ8 MT DTT DMHNTZ8 MA Inhibitor DMHNTZ8 RN Synthesis and pharmacology of 1-deoxy analogs of CP-47,497 and CP-55,940. Bioorg Med Chem. 2008 Jan 1;16(1):322-35. DMHNTZ8 RU https://pubmed.ncbi.nlm.nih.gov/17919913 DMHNTZ8 DI DMHNTZ8 DMHNTZ8 DN JWH-325 DMHNTZ8 MI TTMSFAW DMHNTZ8 MN Cannabinoid receptor 2 (CB2) DMHNTZ8 MT DTT DMHNTZ8 MA Inhibitor DMHNTZ8 RN Synthesis and pharmacology of 1-deoxy analogs of CP-47,497 and CP-55,940. Bioorg Med Chem. 2008 Jan 1;16(1):322-35. DMHNTZ8 RU https://pubmed.ncbi.nlm.nih.gov/17919913 DMK3DUZ DI DMK3DUZ DMK3DUZ DN JWH-337 DMK3DUZ MI TT6OEDT DMK3DUZ MN Cannabinoid receptor 1 (CB1) DMK3DUZ MT DTT DMK3DUZ MA Inhibitor DMK3DUZ RN Synthesis and pharmacology of 1-deoxy analogs of CP-47,497 and CP-55,940. Bioorg Med Chem. 2008 Jan 1;16(1):322-35. DMK3DUZ RU https://pubmed.ncbi.nlm.nih.gov/17919913 DMK3DUZ DI DMK3DUZ DMK3DUZ DN JWH-337 DMK3DUZ MI TTMSFAW DMK3DUZ MN Cannabinoid receptor 2 (CB2) DMK3DUZ MT DTT DMK3DUZ MA Inhibitor DMK3DUZ RN Synthesis and pharmacology of 1-deoxy analogs of CP-47,497 and CP-55,940. Bioorg Med Chem. 2008 Jan 1;16(1):322-35. DMK3DUZ RU https://pubmed.ncbi.nlm.nih.gov/17919913 DMTSZFB DI DMTSZFB DMTSZFB DN JWH-342 DMTSZFB MI TT6OEDT DMTSZFB MN Cannabinoid receptor 1 (CB1) DMTSZFB MT DTT DMTSZFB MA Inhibitor DMTSZFB RN Synthesis and pharmacology of 1-deoxy analogs of CP-47,497 and CP-55,940. Bioorg Med Chem. 2008 Jan 1;16(1):322-35. DMTSZFB RU https://pubmed.ncbi.nlm.nih.gov/17919913 DMTSZFB DI DMTSZFB DMTSZFB DN JWH-342 DMTSZFB MI TTMSFAW DMTSZFB MN Cannabinoid receptor 2 (CB2) DMTSZFB MT DTT DMTSZFB MA Inhibitor DMTSZFB RN Synthesis and pharmacology of 1-deoxy analogs of CP-47,497 and CP-55,940. Bioorg Med Chem. 2008 Jan 1;16(1):322-35. DMTSZFB RU https://pubmed.ncbi.nlm.nih.gov/17919913 DMEU1NS DI DMEU1NS DMEU1NS DN JWH-343 DMEU1NS MI TTMSFAW DMEU1NS MN Cannabinoid receptor 2 (CB2) DMEU1NS MT DTT DMEU1NS MA Inhibitor DMEU1NS RN Synthesis and pharmacology of 1-deoxy analogs of CP-47,497 and CP-55,940. Bioorg Med Chem. 2008 Jan 1;16(1):322-35. DMEU1NS RU https://pubmed.ncbi.nlm.nih.gov/17919913 DM6VZ3T DI DM6VZ3T DM6VZ3T DN JWH-344 DM6VZ3T MI TT6OEDT DM6VZ3T MN Cannabinoid receptor 1 (CB1) DM6VZ3T MT DTT DM6VZ3T MA Inhibitor DM6VZ3T RN Synthesis and pharmacology of 1-deoxy analogs of CP-47,497 and CP-55,940. Bioorg Med Chem. 2008 Jan 1;16(1):322-35. DM6VZ3T RU https://pubmed.ncbi.nlm.nih.gov/17919913 DM6VZ3T DI DM6VZ3T DM6VZ3T DN JWH-344 DM6VZ3T MI TTMSFAW DM6VZ3T MN Cannabinoid receptor 2 (CB2) DM6VZ3T MT DTT DM6VZ3T MA Inhibitor DM6VZ3T RN Synthesis and pharmacology of 1-deoxy analogs of CP-47,497 and CP-55,940. Bioorg Med Chem. 2008 Jan 1;16(1):322-35. DM6VZ3T RU https://pubmed.ncbi.nlm.nih.gov/17919913 DML53SK DI DML53SK DML53SK DN JWH-345 DML53SK MI TT6OEDT DML53SK MN Cannabinoid receptor 1 (CB1) DML53SK MT DTT DML53SK MA Inhibitor DML53SK RN Synthesis and pharmacology of 1-deoxy analogs of CP-47,497 and CP-55,940. Bioorg Med Chem. 2008 Jan 1;16(1):322-35. DML53SK RU https://pubmed.ncbi.nlm.nih.gov/17919913 DML53SK DI DML53SK DML53SK DN JWH-345 DML53SK MI TTMSFAW DML53SK MN Cannabinoid receptor 2 (CB2) DML53SK MT DTT DML53SK MA Inhibitor DML53SK RN Synthesis and pharmacology of 1-deoxy analogs of CP-47,497 and CP-55,940. Bioorg Med Chem. 2008 Jan 1;16(1):322-35. DML53SK RU https://pubmed.ncbi.nlm.nih.gov/17919913 DMHNILP DI DMHNILP DMHNILP DN JWH-346 DMHNILP MI TT6OEDT DMHNILP MN Cannabinoid receptor 1 (CB1) DMHNILP MT DTT DMHNILP MA Inhibitor DMHNILP RN 1-Alkyl-2-aryl-4-(1-naphthoyl)pyrroles: new high affinity ligands for the cannabinoid CB1 and CB2 receptors. Bioorg Med Chem Lett. 2006 Oct 15;16(20):5432-5. DMHNILP RU https://pubmed.ncbi.nlm.nih.gov/16889960 DMHNILP DI DMHNILP DMHNILP DN JWH-346 DMHNILP MI TTMSFAW DMHNILP MN Cannabinoid receptor 2 (CB2) DMHNILP MT DTT DMHNILP MA Inhibitor DMHNILP RN 1-Alkyl-2-aryl-4-(1-naphthoyl)pyrroles: new high affinity ligands for the cannabinoid CB1 and CB2 receptors. Bioorg Med Chem Lett. 2006 Oct 15;16(20):5432-5. DMHNILP RU https://pubmed.ncbi.nlm.nih.gov/16889960 DMK2NQ1 DI DMK2NQ1 DMK2NQ1 DN JWH-347 DMK2NQ1 MI TT6OEDT DMK2NQ1 MN Cannabinoid receptor 1 (CB1) DMK2NQ1 MT DTT DMK2NQ1 MA Inhibitor DMK2NQ1 RN 1-Alkyl-2-aryl-4-(1-naphthoyl)pyrroles: new high affinity ligands for the cannabinoid CB1 and CB2 receptors. Bioorg Med Chem Lett. 2006 Oct 15;16(20):5432-5. DMK2NQ1 RU https://pubmed.ncbi.nlm.nih.gov/16889960 DMK2NQ1 DI DMK2NQ1 DMK2NQ1 DN JWH-347 DMK2NQ1 MI TTMSFAW DMK2NQ1 MN Cannabinoid receptor 2 (CB2) DMK2NQ1 MT DTT DMK2NQ1 MA Inhibitor DMK2NQ1 RN 1-Alkyl-2-aryl-4-(1-naphthoyl)pyrroles: new high affinity ligands for the cannabinoid CB1 and CB2 receptors. Bioorg Med Chem Lett. 2006 Oct 15;16(20):5432-5. DMK2NQ1 RU https://pubmed.ncbi.nlm.nih.gov/16889960 DMQIVPK DI DMQIVPK DMQIVPK DN JWH-348 DMQIVPK MI TT6OEDT DMQIVPK MN Cannabinoid receptor 1 (CB1) DMQIVPK MT DTT DMQIVPK MA Inhibitor DMQIVPK RN 1-Alkyl-2-aryl-4-(1-naphthoyl)pyrroles: new high affinity ligands for the cannabinoid CB1 and CB2 receptors. Bioorg Med Chem Lett. 2006 Oct 15;16(20):5432-5. DMQIVPK RU https://pubmed.ncbi.nlm.nih.gov/16889960 DMQIVPK DI DMQIVPK DMQIVPK DN JWH-348 DMQIVPK MI TTMSFAW DMQIVPK MN Cannabinoid receptor 2 (CB2) DMQIVPK MT DTT DMQIVPK MA Inhibitor DMQIVPK RN 1-Alkyl-2-aryl-4-(1-naphthoyl)pyrroles: new high affinity ligands for the cannabinoid CB1 and CB2 receptors. Bioorg Med Chem Lett. 2006 Oct 15;16(20):5432-5. DMQIVPK RU https://pubmed.ncbi.nlm.nih.gov/16889960 DMFLB1Z DI DMFLB1Z DMFLB1Z DN JWH-363 DMFLB1Z MI TT6OEDT DMFLB1Z MN Cannabinoid receptor 1 (CB1) DMFLB1Z MT DTT DMFLB1Z MA Inhibitor DMFLB1Z RN 1-Alkyl-2-aryl-4-(1-naphthoyl)pyrroles: new high affinity ligands for the cannabinoid CB1 and CB2 receptors. Bioorg Med Chem Lett. 2006 Oct 15;16(20):5432-5. DMFLB1Z RU https://pubmed.ncbi.nlm.nih.gov/16889960 DMFLB1Z DI DMFLB1Z DMFLB1Z DN JWH-363 DMFLB1Z MI TTMSFAW DMFLB1Z MN Cannabinoid receptor 2 (CB2) DMFLB1Z MT DTT DMFLB1Z MA Inhibitor DMFLB1Z RN 1-Alkyl-2-aryl-4-(1-naphthoyl)pyrroles: new high affinity ligands for the cannabinoid CB1 and CB2 receptors. Bioorg Med Chem Lett. 2006 Oct 15;16(20):5432-5. DMFLB1Z RU https://pubmed.ncbi.nlm.nih.gov/16889960 DMP6C4D DI DMP6C4D DMP6C4D DN JWH-364 DMP6C4D MI TT6OEDT DMP6C4D MN Cannabinoid receptor 1 (CB1) DMP6C4D MT DTT DMP6C4D MA Inhibitor DMP6C4D RN 1-Alkyl-2-aryl-4-(1-naphthoyl)pyrroles: new high affinity ligands for the cannabinoid CB1 and CB2 receptors. Bioorg Med Chem Lett. 2006 Oct 15;16(20):5432-5. DMP6C4D RU https://pubmed.ncbi.nlm.nih.gov/16889960 DMP6C4D DI DMP6C4D DMP6C4D DN JWH-364 DMP6C4D MI TTMSFAW DMP6C4D MN Cannabinoid receptor 2 (CB2) DMP6C4D MT DTT DMP6C4D MA Inhibitor DMP6C4D RN 1-Alkyl-2-aryl-4-(1-naphthoyl)pyrroles: new high affinity ligands for the cannabinoid CB1 and CB2 receptors. Bioorg Med Chem Lett. 2006 Oct 15;16(20):5432-5. DMP6C4D RU https://pubmed.ncbi.nlm.nih.gov/16889960 DM2ZXBR DI DM2ZXBR DM2ZXBR DN JWH-365 DM2ZXBR MI TT6OEDT DM2ZXBR MN Cannabinoid receptor 1 (CB1) DM2ZXBR MT DTT DM2ZXBR MA Inhibitor DM2ZXBR RN 1-Alkyl-2-aryl-4-(1-naphthoyl)pyrroles: new high affinity ligands for the cannabinoid CB1 and CB2 receptors. Bioorg Med Chem Lett. 2006 Oct 15;16(20):5432-5. DM2ZXBR RU https://pubmed.ncbi.nlm.nih.gov/16889960 DM2ZXBR DI DM2ZXBR DM2ZXBR DN JWH-365 DM2ZXBR MI TTMSFAW DM2ZXBR MN Cannabinoid receptor 2 (CB2) DM2ZXBR MT DTT DM2ZXBR MA Inhibitor DM2ZXBR RN 1-Alkyl-2-aryl-4-(1-naphthoyl)pyrroles: new high affinity ligands for the cannabinoid CB1 and CB2 receptors. Bioorg Med Chem Lett. 2006 Oct 15;16(20):5432-5. DM2ZXBR RU https://pubmed.ncbi.nlm.nih.gov/16889960 DMSNLFJ DI DMSNLFJ DMSNLFJ DN JWH-366 DMSNLFJ MI TT6OEDT DMSNLFJ MN Cannabinoid receptor 1 (CB1) DMSNLFJ MT DTT DMSNLFJ MA Inhibitor DMSNLFJ RN 1-Alkyl-2-aryl-4-(1-naphthoyl)pyrroles: new high affinity ligands for the cannabinoid CB1 and CB2 receptors. Bioorg Med Chem Lett. 2006 Oct 15;16(20):5432-5. DMSNLFJ RU https://pubmed.ncbi.nlm.nih.gov/16889960 DMSNLFJ DI DMSNLFJ DMSNLFJ DN JWH-366 DMSNLFJ MI TTMSFAW DMSNLFJ MN Cannabinoid receptor 2 (CB2) DMSNLFJ MT DTT DMSNLFJ MA Inhibitor DMSNLFJ RN 1-Alkyl-2-aryl-4-(1-naphthoyl)pyrroles: new high affinity ligands for the cannabinoid CB1 and CB2 receptors. Bioorg Med Chem Lett. 2006 Oct 15;16(20):5432-5. DMSNLFJ RU https://pubmed.ncbi.nlm.nih.gov/16889960 DM7ZF2K DI DM7ZF2K DM7ZF2K DN JWH-367 DM7ZF2K MI TT6OEDT DM7ZF2K MN Cannabinoid receptor 1 (CB1) DM7ZF2K MT DTT DM7ZF2K MA Inhibitor DM7ZF2K RN 1-Alkyl-2-aryl-4-(1-naphthoyl)pyrroles: new high affinity ligands for the cannabinoid CB1 and CB2 receptors. Bioorg Med Chem Lett. 2006 Oct 15;16(20):5432-5. DM7ZF2K RU https://pubmed.ncbi.nlm.nih.gov/16889960 DM7ZF2K DI DM7ZF2K DM7ZF2K DN JWH-367 DM7ZF2K MI TTMSFAW DM7ZF2K MN Cannabinoid receptor 2 (CB2) DM7ZF2K MT DTT DM7ZF2K MA Inhibitor DM7ZF2K RN 1-Alkyl-2-aryl-4-(1-naphthoyl)pyrroles: new high affinity ligands for the cannabinoid CB1 and CB2 receptors. Bioorg Med Chem Lett. 2006 Oct 15;16(20):5432-5. DM7ZF2K RU https://pubmed.ncbi.nlm.nih.gov/16889960 DMK0FNX DI DMK0FNX DMK0FNX DN JWH-368 DMK0FNX MI TT6OEDT DMK0FNX MN Cannabinoid receptor 1 (CB1) DMK0FNX MT DTT DMK0FNX MA Inhibitor DMK0FNX RN 1-Alkyl-2-aryl-4-(1-naphthoyl)pyrroles: new high affinity ligands for the cannabinoid CB1 and CB2 receptors. Bioorg Med Chem Lett. 2006 Oct 15;16(20):5432-5. DMK0FNX RU https://pubmed.ncbi.nlm.nih.gov/16889960 DMK0FNX DI DMK0FNX DMK0FNX DN JWH-368 DMK0FNX MI TTMSFAW DMK0FNX MN Cannabinoid receptor 2 (CB2) DMK0FNX MT DTT DMK0FNX MA Inhibitor DMK0FNX RN 1-Alkyl-2-aryl-4-(1-naphthoyl)pyrroles: new high affinity ligands for the cannabinoid CB1 and CB2 receptors. Bioorg Med Chem Lett. 2006 Oct 15;16(20):5432-5. DMK0FNX RU https://pubmed.ncbi.nlm.nih.gov/16889960 DMPDTWY DI DMPDTWY DMPDTWY DN JWH-369 DMPDTWY MI TT6OEDT DMPDTWY MN Cannabinoid receptor 1 (CB1) DMPDTWY MT DTT DMPDTWY MA Inhibitor DMPDTWY RN 1-Alkyl-2-aryl-4-(1-naphthoyl)pyrroles: new high affinity ligands for the cannabinoid CB1 and CB2 receptors. Bioorg Med Chem Lett. 2006 Oct 15;16(20):5432-5. DMPDTWY RU https://pubmed.ncbi.nlm.nih.gov/16889960 DMPDTWY DI DMPDTWY DMPDTWY DN JWH-369 DMPDTWY MI TTMSFAW DMPDTWY MN Cannabinoid receptor 2 (CB2) DMPDTWY MT DTT DMPDTWY MA Inhibitor DMPDTWY RN 1-Alkyl-2-aryl-4-(1-naphthoyl)pyrroles: new high affinity ligands for the cannabinoid CB1 and CB2 receptors. Bioorg Med Chem Lett. 2006 Oct 15;16(20):5432-5. DMPDTWY RU https://pubmed.ncbi.nlm.nih.gov/16889960 DM6IG7P DI DM6IG7P DM6IG7P DN JWH-370 DM6IG7P MI TT6OEDT DM6IG7P MN Cannabinoid receptor 1 (CB1) DM6IG7P MT DTT DM6IG7P MA Inhibitor DM6IG7P RN 1-Alkyl-2-aryl-4-(1-naphthoyl)pyrroles: new high affinity ligands for the cannabinoid CB1 and CB2 receptors. Bioorg Med Chem Lett. 2006 Oct 15;16(20):5432-5. DM6IG7P RU https://pubmed.ncbi.nlm.nih.gov/16889960 DM6IG7P DI DM6IG7P DM6IG7P DN JWH-370 DM6IG7P MI TTMSFAW DM6IG7P MN Cannabinoid receptor 2 (CB2) DM6IG7P MT DTT DM6IG7P MA Inhibitor DM6IG7P RN 1-Alkyl-2-aryl-4-(1-naphthoyl)pyrroles: new high affinity ligands for the cannabinoid CB1 and CB2 receptors. Bioorg Med Chem Lett. 2006 Oct 15;16(20):5432-5. DM6IG7P RU https://pubmed.ncbi.nlm.nih.gov/16889960 DME0URP DI DME0URP DME0URP DN JWH-371 DME0URP MI TT6OEDT DME0URP MN Cannabinoid receptor 1 (CB1) DME0URP MT DTT DME0URP MA Inhibitor DME0URP RN 1-Alkyl-2-aryl-4-(1-naphthoyl)pyrroles: new high affinity ligands for the cannabinoid CB1 and CB2 receptors. Bioorg Med Chem Lett. 2006 Oct 15;16(20):5432-5. DME0URP RU https://pubmed.ncbi.nlm.nih.gov/16889960 DME0URP DI DME0URP DME0URP DN JWH-371 DME0URP MI TTMSFAW DME0URP MN Cannabinoid receptor 2 (CB2) DME0URP MT DTT DME0URP MA Inhibitor DME0URP RN 1-Alkyl-2-aryl-4-(1-naphthoyl)pyrroles: new high affinity ligands for the cannabinoid CB1 and CB2 receptors. Bioorg Med Chem Lett. 2006 Oct 15;16(20):5432-5. DME0URP RU https://pubmed.ncbi.nlm.nih.gov/16889960 DM9D3GM DI DM9D3GM DM9D3GM DN JWH-372 DM9D3GM MI TT6OEDT DM9D3GM MN Cannabinoid receptor 1 (CB1) DM9D3GM MT DTT DM9D3GM MA Inhibitor DM9D3GM RN 1-Alkyl-2-aryl-4-(1-naphthoyl)pyrroles: new high affinity ligands for the cannabinoid CB1 and CB2 receptors. Bioorg Med Chem Lett. 2006 Oct 15;16(20):5432-5. DM9D3GM RU https://pubmed.ncbi.nlm.nih.gov/16889960 DM9D3GM DI DM9D3GM DM9D3GM DN JWH-372 DM9D3GM MI TTMSFAW DM9D3GM MN Cannabinoid receptor 2 (CB2) DM9D3GM MT DTT DM9D3GM MA Inhibitor DM9D3GM RN 1-Alkyl-2-aryl-4-(1-naphthoyl)pyrroles: new high affinity ligands for the cannabinoid CB1 and CB2 receptors. Bioorg Med Chem Lett. 2006 Oct 15;16(20):5432-5. DM9D3GM RU https://pubmed.ncbi.nlm.nih.gov/16889960 DMWP84R DI DMWP84R DMWP84R DN JWH-373 DMWP84R MI TT6OEDT DMWP84R MN Cannabinoid receptor 1 (CB1) DMWP84R MT DTT DMWP84R MA Inhibitor DMWP84R RN 1-Alkyl-2-aryl-4-(1-naphthoyl)pyrroles: new high affinity ligands for the cannabinoid CB1 and CB2 receptors. Bioorg Med Chem Lett. 2006 Oct 15;16(20):5432-5. DMWP84R RU https://pubmed.ncbi.nlm.nih.gov/16889960 DMWP84R DI DMWP84R DMWP84R DN JWH-373 DMWP84R MI TTMSFAW DMWP84R MN Cannabinoid receptor 2 (CB2) DMWP84R MT DTT DMWP84R MA Inhibitor DMWP84R RN 1-Alkyl-2-aryl-4-(1-naphthoyl)pyrroles: new high affinity ligands for the cannabinoid CB1 and CB2 receptors. Bioorg Med Chem Lett. 2006 Oct 15;16(20):5432-5. DMWP84R RU https://pubmed.ncbi.nlm.nih.gov/16889960 DMU1HA7 DI DMU1HA7 DMU1HA7 DN JWH-385 DMU1HA7 MI TT6OEDT DMU1HA7 MN Cannabinoid receptor 1 (CB1) DMU1HA7 MT DTT DMU1HA7 MA Inhibitor DMU1HA7 RN Synthesis and pharmacology of 1-deoxy analogs of CP-47,497 and CP-55,940. Bioorg Med Chem. 2008 Jan 1;16(1):322-35. DMU1HA7 RU https://pubmed.ncbi.nlm.nih.gov/17919913 DMU1HA7 DI DMU1HA7 DMU1HA7 DN JWH-385 DMU1HA7 MI TTMSFAW DMU1HA7 MN Cannabinoid receptor 2 (CB2) DMU1HA7 MT DTT DMU1HA7 MA Inhibitor DMU1HA7 RN Synthesis and pharmacology of 1-deoxy analogs of CP-47,497 and CP-55,940. Bioorg Med Chem. 2008 Jan 1;16(1):322-35. DMU1HA7 RU https://pubmed.ncbi.nlm.nih.gov/17919913 DMMUBIF DI DMMUBIF DMMUBIF DN JWH-392 DMMUBIF MI TT6OEDT DMMUBIF MN Cannabinoid receptor 1 (CB1) DMMUBIF MT DTT DMMUBIF MA Inhibitor DMMUBIF RN Synthesis and pharmacology of 1-deoxy analogs of CP-47,497 and CP-55,940. Bioorg Med Chem. 2008 Jan 1;16(1):322-35. DMMUBIF RU https://pubmed.ncbi.nlm.nih.gov/17919913 DMMUBIF DI DMMUBIF DMMUBIF DN JWH-392 DMMUBIF MI TTMSFAW DMMUBIF MN Cannabinoid receptor 2 (CB2) DMMUBIF MT DTT DMMUBIF MA Inhibitor DMMUBIF RN Synthesis and pharmacology of 1-deoxy analogs of CP-47,497 and CP-55,940. Bioorg Med Chem. 2008 Jan 1;16(1):322-35. DMMUBIF RU https://pubmed.ncbi.nlm.nih.gov/17919913 DMFL6B9 DI DMFL6B9 DMFL6B9 DN JWH-401 DMFL6B9 MI TT6OEDT DMFL6B9 MN Cannabinoid receptor 1 (CB1) DMFL6B9 MT DTT DMFL6B9 MA Inhibitor DMFL6B9 RN Synthesis and pharmacology of 1-deoxy analogs of CP-47,497 and CP-55,940. Bioorg Med Chem. 2008 Jan 1;16(1):322-35. DMFL6B9 RU https://pubmed.ncbi.nlm.nih.gov/17919913 DMFL6B9 DI DMFL6B9 DMFL6B9 DN JWH-401 DMFL6B9 MI TTMSFAW DMFL6B9 MN Cannabinoid receptor 2 (CB2) DMFL6B9 MT DTT DMFL6B9 MA Inhibitor DMFL6B9 RN Synthesis and pharmacology of 1-deoxy analogs of CP-47,497 and CP-55,940. Bioorg Med Chem. 2008 Jan 1;16(1):322-35. DMFL6B9 RU https://pubmed.ncbi.nlm.nih.gov/17919913 DM8TQIF DI DM8TQIF DM8TQIF DN JWH-402 DM8TQIF MI TT6OEDT DM8TQIF MN Cannabinoid receptor 1 (CB1) DM8TQIF MT DTT DM8TQIF MA Inhibitor DM8TQIF RN Synthesis and pharmacology of 1-deoxy analogs of CP-47,497 and CP-55,940. Bioorg Med Chem. 2008 Jan 1;16(1):322-35. DM8TQIF RU https://pubmed.ncbi.nlm.nih.gov/17919913 DM8TQIF DI DM8TQIF DM8TQIF DN JWH-402 DM8TQIF MI TTMSFAW DM8TQIF MN Cannabinoid receptor 2 (CB2) DM8TQIF MT DTT DM8TQIF MA Inhibitor DM8TQIF RN Synthesis and pharmacology of 1-deoxy analogs of CP-47,497 and CP-55,940. Bioorg Med Chem. 2008 Jan 1;16(1):322-35. DM8TQIF RU https://pubmed.ncbi.nlm.nih.gov/17919913 DMRG1VI DI DMRG1VI DMRG1VI DN JWH-403 DMRG1VI MI TT6OEDT DMRG1VI MN Cannabinoid receptor 1 (CB1) DMRG1VI MT DTT DMRG1VI MA Inhibitor DMRG1VI RN Synthesis and pharmacology of 1-deoxy analogs of CP-47,497 and CP-55,940. Bioorg Med Chem. 2008 Jan 1;16(1):322-35. DMRG1VI RU https://pubmed.ncbi.nlm.nih.gov/17919913 DMRG1VI DI DMRG1VI DMRG1VI DN JWH-403 DMRG1VI MI TTMSFAW DMRG1VI MN Cannabinoid receptor 2 (CB2) DMRG1VI MT DTT DMRG1VI MA Inhibitor DMRG1VI RN Synthesis and pharmacology of 1-deoxy analogs of CP-47,497 and CP-55,940. Bioorg Med Chem. 2008 Jan 1;16(1):322-35. DMRG1VI RU https://pubmed.ncbi.nlm.nih.gov/17919913 DM3KWER DI DM3KWER DM3KWER DN JWH-404 DM3KWER MI TT6OEDT DM3KWER MN Cannabinoid receptor 1 (CB1) DM3KWER MT DTT DM3KWER MA Inhibitor DM3KWER RN Synthesis and pharmacology of 1-deoxy analogs of CP-47,497 and CP-55,940. Bioorg Med Chem. 2008 Jan 1;16(1):322-35. DM3KWER RU https://pubmed.ncbi.nlm.nih.gov/17919913 DM3KWER DI DM3KWER DM3KWER DN JWH-404 DM3KWER MI TTMSFAW DM3KWER MN Cannabinoid receptor 2 (CB2) DM3KWER MT DTT DM3KWER MA Inhibitor DM3KWER RN Synthesis and pharmacology of 1-deoxy analogs of CP-47,497 and CP-55,940. Bioorg Med Chem. 2008 Jan 1;16(1):322-35. DM3KWER RU https://pubmed.ncbi.nlm.nih.gov/17919913 DM57TN3 DI DM57TN3 DM57TN3 DN JWH-405 DM57TN3 MI TT6OEDT DM57TN3 MN Cannabinoid receptor 1 (CB1) DM57TN3 MT DTT DM57TN3 MA Inhibitor DM57TN3 RN Synthesis and pharmacology of 1-deoxy analogs of CP-47,497 and CP-55,940. Bioorg Med Chem. 2008 Jan 1;16(1):322-35. DM57TN3 RU https://pubmed.ncbi.nlm.nih.gov/17919913 DM57TN3 DI DM57TN3 DM57TN3 DN JWH-405 DM57TN3 MI TTMSFAW DM57TN3 MN Cannabinoid receptor 2 (CB2) DM57TN3 MT DTT DM57TN3 MA Inhibitor DM57TN3 RN Synthesis and pharmacology of 1-deoxy analogs of CP-47,497 and CP-55,940. Bioorg Med Chem. 2008 Jan 1;16(1):322-35. DM57TN3 RU https://pubmed.ncbi.nlm.nih.gov/17919913 DMNP7GD DI DMNP7GD DMNP7GD DN JWH-406 DMNP7GD MI TT6OEDT DMNP7GD MN Cannabinoid receptor 1 (CB1) DMNP7GD MT DTT DMNP7GD MA Inhibitor DMNP7GD RN Synthesis and pharmacology of 1-deoxy analogs of CP-47,497 and CP-55,940. Bioorg Med Chem. 2008 Jan 1;16(1):322-35. DMNP7GD RU https://pubmed.ncbi.nlm.nih.gov/17919913 DMNP7GD DI DMNP7GD DMNP7GD DN JWH-406 DMNP7GD MI TTMSFAW DMNP7GD MN Cannabinoid receptor 2 (CB2) DMNP7GD MT DTT DMNP7GD MA Inhibitor DMNP7GD RN Synthesis and pharmacology of 1-deoxy analogs of CP-47,497 and CP-55,940. Bioorg Med Chem. 2008 Jan 1;16(1):322-35. DMNP7GD RU https://pubmed.ncbi.nlm.nih.gov/17919913 DMZQ0V9 DI DMZQ0V9 DMZQ0V9 DN JWH-407 DMZQ0V9 MI TT6OEDT DMZQ0V9 MN Cannabinoid receptor 1 (CB1) DMZQ0V9 MT DTT DMZQ0V9 MA Inhibitor DMZQ0V9 RN Synthesis and pharmacology of 1-deoxy analogs of CP-47,497 and CP-55,940. Bioorg Med Chem. 2008 Jan 1;16(1):322-35. DMZQ0V9 RU https://pubmed.ncbi.nlm.nih.gov/17919913 DMZQ0V9 DI DMZQ0V9 DMZQ0V9 DN JWH-407 DMZQ0V9 MI TTMSFAW DMZQ0V9 MN Cannabinoid receptor 2 (CB2) DMZQ0V9 MT DTT DMZQ0V9 MA Inhibitor DMZQ0V9 RN Synthesis and pharmacology of 1-deoxy analogs of CP-47,497 and CP-55,940. Bioorg Med Chem. 2008 Jan 1;16(1):322-35. DMZQ0V9 RU https://pubmed.ncbi.nlm.nih.gov/17919913 DM89602 DI DM89602 DM89602 DN JWH-440 DM89602 MI TT6OEDT DM89602 MN Cannabinoid receptor 1 (CB1) DM89602 MT DTT DM89602 MA Inhibitor DM89602 RN Synthesis and pharmacology of 1-methoxy analogs of CP-47,497. Bioorg Med Chem. 2010 Aug 1;18(15):5475-82. DM89602 RU https://pubmed.ncbi.nlm.nih.gov/20621488 DM89602 DI DM89602 DM89602 DN JWH-440 DM89602 MI TTMSFAW DM89602 MN Cannabinoid receptor 2 (CB2) DM89602 MT DTT DM89602 MA Inhibitor DM89602 RN Synthesis and pharmacology of 1-methoxy analogs of CP-47,497. Bioorg Med Chem. 2010 Aug 1;18(15):5475-82. DM89602 RU https://pubmed.ncbi.nlm.nih.gov/20621488 DM7R1XS DI DM7R1XS DM7R1XS DN JWH-441 DM7R1XS MI TTMSFAW DM7R1XS MN Cannabinoid receptor 2 (CB2) DM7R1XS MT DTT DM7R1XS MA Inhibitor DM7R1XS RN Synthesis and pharmacology of 1-methoxy analogs of CP-47,497. Bioorg Med Chem. 2010 Aug 1;18(15):5475-82. DM7R1XS RU https://pubmed.ncbi.nlm.nih.gov/20621488 DMX6F1L DI DMX6F1L DMX6F1L DN JWH-442 DMX6F1L MI TT6OEDT DMX6F1L MN Cannabinoid receptor 1 (CB1) DMX6F1L MT DTT DMX6F1L MA Inhibitor DMX6F1L RN Synthesis and pharmacology of 1-methoxy analogs of CP-47,497. Bioorg Med Chem. 2010 Aug 1;18(15):5475-82. DMX6F1L RU https://pubmed.ncbi.nlm.nih.gov/20621488 DMX6F1L DI DMX6F1L DMX6F1L DN JWH-442 DMX6F1L MI TTMSFAW DMX6F1L MN Cannabinoid receptor 2 (CB2) DMX6F1L MT DTT DMX6F1L MA Inhibitor DMX6F1L RN Synthesis and pharmacology of 1-methoxy analogs of CP-47,497. Bioorg Med Chem. 2010 Aug 1;18(15):5475-82. DMX6F1L RU https://pubmed.ncbi.nlm.nih.gov/20621488 DMWA8B0 DI DMWA8B0 DMWA8B0 DN JZL184 DMWA8B0 MI TTZ963I DMWA8B0 MN Monoglyceride lipase (MAGL) DMWA8B0 MT DTT DMWA8B0 MA Inhibitor DMWA8B0 RN Selective blockade of 2-arachidonoylglycerol hydrolysis produces cannabinoid behavioral effects. Nat Chem Biol. 2009 Jan;5(1):37-44. DMWA8B0 RU https://pubmed.ncbi.nlm.nih.gov/19029917 DMEOCKZ DI DMEOCKZ DMEOCKZ DN JZL195 DMEOCKZ MI TT2EJXQ DMEOCKZ MN Acyloxyacyl hydrolase (neutrophil) DMEOCKZ MT DTT DMEOCKZ MA Inhibitor DMEOCKZ RN A high-throughput, multiplexed assay for superfamily-wide profiling of enzyme activity. Nat Chem Biol. 2014 Aug;10(8):656-63. DMEOCKZ RU https://pubmed.ncbi.nlm.nih.gov/24997602 DMP8M9Q DI DMP8M9Q DMP8M9Q DN K00024 DMP8M9Q MI TTH6V3D DMP8M9Q MN Cyclin-dependent kinase 1 (CDK1) DMP8M9Q MT DTT DMP8M9Q MA Inhibitor DMP8M9Q RN Synthesis, structure-activity relationship, and biological studies of indolocarbazoles as potent cyclin D1-CDK4 inhibitors. J Med Chem. 2003 May 22;46(11):2027-30. DMP8M9Q RU https://pubmed.ncbi.nlm.nih.gov/12747775 DMP8M9Q DI DMP8M9Q DMP8M9Q DN K00024 DMP8M9Q MI TT7HF4W DMP8M9Q MN Cyclin-dependent kinase 2 (CDK2) DMP8M9Q MT DTT DMP8M9Q MA Inhibitor DMP8M9Q RN Synthesis, structure-activity relationship, and biological studies of indolocarbazoles as potent cyclin D1-CDK4 inhibitors. J Med Chem. 2003 May 22;46(11):2027-30. DMP8M9Q RU https://pubmed.ncbi.nlm.nih.gov/12747775 DMP8M9Q DI DMP8M9Q DMP8M9Q DN K00024 DMP8M9Q MI TT0PG8F DMP8M9Q MN Cyclin-dependent kinase 4 (CDK4) DMP8M9Q MT DTT DMP8M9Q MA Inhibitor DMP8M9Q RN Synthesis, structure-activity relationship, and biological studies of indolocarbazoles as potent cyclin D1-CDK4 inhibitors. J Med Chem. 2003 May 22;46(11):2027-30. DMP8M9Q RU https://pubmed.ncbi.nlm.nih.gov/12747775 DM2BKU8 DI DM2BKU8 DM2BKU8 DN K00244 DM2BKU8 MI TTLYXIT DM2BKU8 MN Aurora kinase C (AURKC) DM2BKU8 MT DTT DM2BKU8 MA Inhibitor DM2BKU8 RN The discovery of the potent aurora inhibitor MK-0457 (VX-680). Bioorg Med Chem Lett. 2009 Jul 1;19(13):3586-92. DM2BKU8 RU https://pubmed.ncbi.nlm.nih.gov/19447622 DM2BKU8 DI DM2BKU8 DM2BKU8 DN K00244 DM2BKU8 MI TTRSMW9 DM2BKU8 MN Glycogen synthase kinase-3 beta (GSK-3B) DM2BKU8 MT DTT DM2BKU8 MA Inhibitor DM2BKU8 RN The discovery of the potent aurora inhibitor MK-0457 (VX-680). Bioorg Med Chem Lett. 2009 Jul 1;19(13):3586-92. DM2BKU8 RU https://pubmed.ncbi.nlm.nih.gov/19447622 DM2BKU8 DI DM2BKU8 DM2BKU8 DN K00244 DM2BKU8 MI TT6PKBN DM2BKU8 MN Proto-oncogene c-Src (SRC) DM2BKU8 MT DTT DM2BKU8 MA Inhibitor DM2BKU8 RN The discovery of the potent aurora inhibitor MK-0457 (VX-680). Bioorg Med Chem Lett. 2009 Jul 1;19(13):3586-92. DM2BKU8 RU https://pubmed.ncbi.nlm.nih.gov/19447622 DMWZJG6 DI DMWZJG6 DMWZJG6 DN K00248 DMWZJG6 MI TTYPXQF DMWZJG6 MN Protein kinase C beta (PRKCB) DMWZJG6 MT DTT DMWZJG6 MA Inhibitor DMWZJG6 RN Synthesis of anilino-monoindolylmaleimides as potent and selective PKCbeta inhibitors. Bioorg Med Chem Lett. 2004 Oct 18;14(20):5171-4. DMWZJG6 RU https://pubmed.ncbi.nlm.nih.gov/15380221 DM1RP5Q DI DM1RP5Q DM1RP5Q DN K00592a DM1RP5Q MI TTOU65C DM1RP5Q MN Tyrosine-protein kinase SYK (SYK) DM1RP5Q MT DTT DM1RP5Q MA Inhibitor DM1RP5Q RN Synthetic studies on novel Syk inhibitors. Part 1: Synthesis and structure-activity relationships of pyrimidine-5-carboxamide derivatives. Bioorg Med Chem. 2005 Aug 15;13(16):4936-51. DM1RP5Q RU https://pubmed.ncbi.nlm.nih.gov/15990316 DM1RP5Q DI DM1RP5Q DM1RP5Q DN K00592a DM1RP5Q MI TTUMHT8 DM1RP5Q MN Tyrosine-protein kinase ZAP-70 (ZAP-70) DM1RP5Q MT DTT DM1RP5Q MA Inhibitor DM1RP5Q RN Synthetic studies on novel Syk inhibitors. Part 1: Synthesis and structure-activity relationships of pyrimidine-5-carboxamide derivatives. Bioorg Med Chem. 2005 Aug 15;13(16):4936-51. DM1RP5Q RU https://pubmed.ncbi.nlm.nih.gov/15990316 DME65H8 DI DME65H8 DME65H8 DN K185 DME65H8 MI TT0WAIE DME65H8 MN Melatonin receptor type 1A (MTNR1A) DME65H8 MT DTT DME65H8 MA Antagonist DME65H8 RN Mapping the melatonin receptor. 6. Melatonin agonists and antagonists derived from 6H-isoindolo[2,1-a]indoles, 5,6-dihydroindolo[2,1-a]isoquinolines, and 6,7-dihydro-5H-benzo[c]azepino[2,1-a]indoles.J Med Chem. 2000 Mar 23;43(6):1050-61. DME65H8 RU https://pubmed.ncbi.nlm.nih.gov/10737738 DMT68RG DI DMT68RG DMT68RG DN K252a DMT68RG MI TTSLUMT DMT68RG MN Protein kinase D (PRKD1) DMT68RG MT DTT DMT68RG MA Inhibitor DMT68RG RN Protein kinase D as a potential new target for cancer therapy. Biochim Biophys Acta. 2010 Dec;1806(2):183-92. DMT68RG RU https://pubmed.ncbi.nlm.nih.gov/20580776 DMCZPH4 DI DMCZPH4 DMCZPH4 DN K-252a analogue DMCZPH4 MI TTTDVOJ DMCZPH4 MN Tropomyosin-related kinase A (TrkA) DMCZPH4 MT DTT DMCZPH4 MA Inhibitor DMCZPH4 RN Synthesis, modeling, and in vitro activity of (3'S)-epi-K-252a analogues. Elucidating the stereochemical requirements of the 3'-sugar alcohol on tr... J Med Chem. 2005 Jun 2;48(11):3776-83. DMCZPH4 RU https://pubmed.ncbi.nlm.nih.gov/15916429 DMCZPH4 DI DMCZPH4 DMCZPH4 DN K-252a analogue DMCZPH4 MI TTUTJGQ DMCZPH4 MN Vascular endothelial growth factor receptor 2 (KDR) DMCZPH4 MT DTT DMCZPH4 MA Inhibitor DMCZPH4 RN Synthesis, modeling, and in vitro activity of (3'S)-epi-K-252a analogues. Elucidating the stereochemical requirements of the 3'-sugar alcohol on tr... J Med Chem. 2005 Jun 2;48(11):3776-83. DMCZPH4 RU https://pubmed.ncbi.nlm.nih.gov/15916429 DMYSMWI DI DMYSMWI DMYSMWI DN K-454 DMYSMWI MI TTRMX3V DMYSMWI MN Janus kinase 2 (JAK-2) DMYSMWI MT DTT DMYSMWI MA Inhibitor DMYSMWI RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2048). DMYSMWI RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2048 DMUKTBF DI DMUKTBF DMUKTBF DN K-6015 DMUKTBF MI DEASPQ0 DMUKTBF MN Beta-glycosidase (glyB) DMUKTBF MT DME DMUKTBF MA Metabolism DMUKTBF RN Comparison of anti-Campylobacter activity of free thymol and thymol-beta-D-glucopyranoside in absence or presence of beta-glycoside-hydrolysing gut bacteria. Food Chem. 2015 Apr 15;173:92-8. DMUKTBF RU https://pubmed.ncbi.nlm.nih.gov/25465999 DMIFCMW DI DMIFCMW DMIFCMW DN K-777 DMIFCMW MI TT2SUAQ DMIFCMW MN Cysteine protease (CYP) DMIFCMW MT DTT DMIFCMW MA Inhibitor DMIFCMW RN Novel non-peptidic vinylsulfones targeting the S2 and S3 subsites of parasite cysteine proteases. Bioorg Med Chem Lett. 2009 Nov 1;19(21):6218-21. DMIFCMW RU https://pubmed.ncbi.nlm.nih.gov/19773167 DMIFCMW DI DMIFCMW DMIFCMW DN K-777 DMIFCMW MI TTEAID7 DMIFCMW MN Trypanosoma Cruzipain (Trypano CYSP) DMIFCMW MT DTT DMIFCMW MA Inhibitor DMIFCMW RN Novel non-peptidic vinylsulfones targeting the S2 and S3 subsites of parasite cysteine proteases. Bioorg Med Chem Lett. 2009 Nov 1;19(21):6218-21. DMIFCMW RU https://pubmed.ncbi.nlm.nih.gov/19773167 DM4GSHY DI DM4GSHY DM4GSHY DN KA-10X DM4GSHY MI TTW2R9X DM4GSHY MN GTPase NRas (NRAS) DM4GSHY MT DTT DM4GSHY MA Antagonist DM4GSHY RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2823). DM4GSHY RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2823 DMUWA2G DI DMUWA2G DMUWA2G DN KAEMPFERIDE DMUWA2G MI TTI84H7 DMUWA2G MN Cytochrome P450 1B1 (CYP1B1) DMUWA2G MT DTT DMUWA2G MA Inhibitor DMUWA2G RN Selective inhibition of methoxyflavonoids on human CYP1B1 activity. Bioorg Med Chem. 2010 Sep 1;18(17):6310-5. DMUWA2G RU https://pubmed.ncbi.nlm.nih.gov/20696580 DMHEMUB DI DMHEMUB DMHEMUB DN Kaempferol DMHEMUB MI TTFBNVI DMHEMUB MN Aldose reductase (AKR1B1) DMHEMUB MT DTT DMHEMUB MA Inhibitor DMHEMUB RN Erigeroflavanone, a flavanone derivative from the flowers of Erigeron annuus with protein glycation and aldose reductase inhibitory activity. J Nat Prod. 2008 Apr;71(4):713-5. DMHEMUB RU https://pubmed.ncbi.nlm.nih.gov/18298080 DMHEMUB DI DMHEMUB DMHEMUB DN Kaempferol DMHEMUB MI TTKPW01 DMHEMUB MN Androgen receptor messenger RNA (AR mRNA) DMHEMUB MT DTT DMHEMUB MA Inhibitor DMHEMUB RN Effect of flavonoids on androgen and glucocorticoid receptors based on in vitro reporter gene assay. Bioorg Med Chem Lett. 2009 Aug 15;19(16):4706-10. DMHEMUB RU https://pubmed.ncbi.nlm.nih.gov/19592245 DMHEMUB DI DMHEMUB DMHEMUB DN Kaempferol DMHEMUB MI TTN9T81 DMHEMUB MN Arachidonate 15-lipoxygenase (15-LOX) DMHEMUB MT DTT DMHEMUB MA Inhibitor DMHEMUB RN Lipoxygenase inhibitory constituents of the fruits of noni (Morinda citrifolia) collected in Tahiti. J Nat Prod. 2007 May;70(5):859-62. DMHEMUB RU https://pubmed.ncbi.nlm.nih.gov/17378609 DMHEMUB DI DMHEMUB DMHEMUB DN Kaempferol DMHEMUB MI TTI84H7 DMHEMUB MN Cytochrome P450 1B1 (CYP1B1) DMHEMUB MT DTT DMHEMUB MA Inhibitor DMHEMUB RN Selective inhibition of methoxyflavonoids on human CYP1B1 activity. Bioorg Med Chem. 2010 Sep 1;18(17):6310-5. DMHEMUB RU https://pubmed.ncbi.nlm.nih.gov/20696580 DMHEMUB DI DMHEMUB DMHEMUB DN Kaempferol DMHEMUB MI TTIWB6L DMHEMUB MN Estradiol 17 beta-dehydrogenase 1 (17-beta-HSD1) DMHEMUB MT DTT DMHEMUB MA Inhibitor DMHEMUB RN Discovery of nonsteroidal 17beta-hydroxysteroid dehydrogenase 1 inhibitors by pharmacophore-based screening of virtual compound libraries. J Med Chem. 2008 Jul 24;51(14):4188-99. DMHEMUB RU https://pubmed.ncbi.nlm.nih.gov/18533708 DMHEMUB DI DMHEMUB DMHEMUB DN Kaempferol DMHEMUB MI TT50QJ3 DMHEMUB MN Influenza Neuraminidase (Influ NA) DMHEMUB MT DTT DMHEMUB MA Inhibitor DMHEMUB RN Neuraminidase inhibitory activities of flavonols isolated from Rhodiola rosea roots and their in vitro anti-influenza viral activities. Bioorg Med Chem. 2009 Oct 1;17(19):6816-23. DMHEMUB RU https://pubmed.ncbi.nlm.nih.gov/19729316 DMHEMUB DI DMHEMUB DMHEMUB DN Kaempferol DMHEMUB MI TTV9A7R DMHEMUB MN Lactoylglutathione lyase (GLO1) DMHEMUB MT DTT DMHEMUB MA Inhibitor DMHEMUB RN Structure-activity relationship of human GLO I inhibitory natural flavonoids and their growth inhibitory effects. Bioorg Med Chem. 2008 Apr 1;16(7):3969-75. DMHEMUB RU https://pubmed.ncbi.nlm.nih.gov/18258440 DMHEMUB DI DMHEMUB DMHEMUB DN Kaempferol DMHEMUB MI TTSJ6Q4 DMHEMUB MN LOX-5 messenger RNA (ALOX5 mRNA) DMHEMUB MT DTT DMHEMUB MA Inhibitor DMHEMUB RN Lipoxygenase inhibitory constituents of the fruits of noni (Morinda citrifolia) collected in Tahiti. J Nat Prod. 2007 May;70(5):859-62. DMHEMUB RU https://pubmed.ncbi.nlm.nih.gov/17378609 DMHEMUB DI DMHEMUB DMHEMUB DN Kaempferol DMHEMUB MI TTBE4IR DMHEMUB MN Plasmodium Oxoacyl-[acyl-carrier protein] reductase (Malaria fabG) DMHEMUB MT DTT DMHEMUB MA Inhibitor DMHEMUB RN Inhibition of Plasmodium falciparum fatty acid biosynthesis: evaluation of FabG, FabZ, and FabI as drug targets for flavonoids. J Med Chem. 2006 Jun 1;49(11):3345-53. DMHEMUB RU https://pubmed.ncbi.nlm.nih.gov/16722653 DMUCZ3F DI DMUCZ3F DMUCZ3F DN Kaempferol-3-O-(2''-O-galloyl)-glucoside DMUCZ3F MI TTL69WB DMUCZ3F MN Angiotensin-converting enzyme (ACE) DMUCZ3F MT DTT DMUCZ3F MA Inhibitor DMUCZ3F RN Inhibitory effects of various flavonoids isolated from leaves of persimmon on angiotensin-converting enzyme activity. J Nat Prod. 1987 Jul-Aug;50(4):680-3. DMUCZ3F RU https://pubmed.ncbi.nlm.nih.gov/3430165 DMBG7X1 DI DMBG7X1 DMBG7X1 DN Kaempferol-3-O-methyl ether DMBG7X1 MI TTVG215 DMBG7X1 MN Debrisoquine 4-hydroxylase (CYP2D6) DMBG7X1 MT DTT DMBG7X1 MA Inhibitor DMBG7X1 RN Sesquiterpenes and flavonol glycosides from Zingiber aromaticum and their CYP3A4 and CYP2D6 inhibitory activities. J Nat Prod. 2004 Jul;67(7):1079-83. DMBG7X1 RU https://pubmed.ncbi.nlm.nih.gov/15270556 DMN4EUB DI DMN4EUB DMN4EUB DN KAG-308 DMN4EUB MI TT79WV3 DMN4EUB MN Prostaglandin E2 receptor EP4 (PTGER4) DMN4EUB MT DTT DMN4EUB MA Agonist DMN4EUB RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 343). DMN4EUB RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=343 DMRT6OP DI DMRT6OP DMRT6OP DN kallidin DMRT6OP MI TTGY8IW DMRT6OP MN B2 bradykinin receptor (BDKRB2) DMRT6OP MT DTT DMRT6OP MA Agonist DMRT6OP RN Differential pharmacology of cloned human and mouse B2 bradykinin receptors. Mol Pharmacol. 1994 Jan;45(1):1-8. DMRT6OP RU https://pubmed.ncbi.nlm.nih.gov/8302267 DM7YAE0 DI DM7YAE0 DM7YAE0 DN kallstroemin D DM7YAE0 MI TT1UCIJ DM7YAE0 MN C-X-C chemokine receptor type 3 (CXCR3) DM7YAE0 MT DTT DM7YAE0 MA Antagonist DM7YAE0 RN Discovery of structurally diverse natural product antagonists of chemokine receptor CXCR3. Mol Divers. 2005;9(1-3):123-9. DM7YAE0 RU https://pubmed.ncbi.nlm.nih.gov/15789559 DMFR79L DI DMFR79L DMFR79L DN Kaltostat DMFR79L MI DE65RJO DMFR79L MN Beta-glucuronidase (uidA) DMFR79L MT DME DMFR79L MA Metabolism DMFR79L RN Active site flexibility revealed in crystal structures of Parabacteroides merdae beta-glucuronidase from the human gut microbiome. Protein Sci. 2018 Dec;27(12):2010-2022. DMFR79L RU https://pubmed.ncbi.nlm.nih.gov/30230652 DMXAK75 DI DMXAK75 DMXAK75 DN KAR-1880 DMXAK75 MI TTSHTOI DMXAK75 MN Histone deacetylase 2 (HDAC2) DMXAK75 MT DTT DMXAK75 MA Inhibitor DMXAK75 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2616). DMXAK75 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2616 DMMIA38 DI DMMIA38 DMMIA38 DN kassinin DMMIA38 MI TTBPGLU DMMIA38 MN Neuromedin-K receptor (TACR3) DMMIA38 MT DTT DMMIA38 MA Agonist DMMIA38 RN The unpredicted high affinities of a large number of naturally occurring tachykinins for chimeric NK1/NK3 receptors suggest a role for an inhibitory domain in determining receptor specificity. J BiolChem. 1996 Aug 23;271(34):20250-7. DMMIA38 RU https://pubmed.ncbi.nlm.nih.gov/8702757 DMMIA38 DI DMMIA38 DMMIA38 DN kassinin DMMIA38 MI TTZPO1L DMMIA38 MN Substance-P receptor (TACR1) DMMIA38 MT DTT DMMIA38 MA Agonist DMMIA38 RN The unpredicted high affinities of a large number of naturally occurring tachykinins for chimeric NK1/NK3 receptors suggest a role for an inhibitory domain in determining receptor specificity. J BiolChem. 1996 Aug 23;271(34):20250-7. DMMIA38 RU https://pubmed.ncbi.nlm.nih.gov/8702757 DM513QY DI DM513QY DM513QY DN KATSUMADAIN A DM513QY MI TT50QJ3 DM513QY MN Influenza Neuraminidase (Influ NA) DM513QY MT DTT DM513QY MA Inhibitor DM513QY RN Antiviral potential and molecular insight into neuraminidase inhibiting diarylheptanoids from Alpinia katsumadai. J Med Chem. 2010 Jan 28;53(2):778-86. DM513QY RU https://pubmed.ncbi.nlm.nih.gov/20014777 DMS527J DI DMS527J DMS527J DN Kazinol C DMS527J MI TTULVH8 DMS527J MN Tyrosinase (TYR) DMS527J MT DTT DMS527J MA Inhibitor DMS527J RN Tyrosinase inhibitory effects of 1,3-diphenylpropanes from Broussonetia kazinoki. Bioorg Med Chem. 2009 Jan 1;17(1):35-41. DMS527J RU https://pubmed.ncbi.nlm.nih.gov/19046886 DMFVT81 DI DMFVT81 DMFVT81 DN Kazinol F DMFVT81 MI TTULVH8 DMFVT81 MN Tyrosinase (TYR) DMFVT81 MT DTT DMFVT81 MA Inhibitor DMFVT81 RN Tyrosinase inhibitory effects of 1,3-diphenylpropanes from Broussonetia kazinoki. Bioorg Med Chem. 2009 Jan 1;17(1):35-41. DMFVT81 RU https://pubmed.ncbi.nlm.nih.gov/19046886 DMEV2AL DI DMEV2AL DMEV2AL DN KAZINOL S DMEV2AL MI TTULVH8 DMEV2AL MN Tyrosinase (TYR) DMEV2AL MT DTT DMEV2AL MA Inhibitor DMEV2AL RN Tyrosinase inhibitory effects of 1,3-diphenylpropanes from Broussonetia kazinoki. Bioorg Med Chem. 2009 Jan 1;17(1):35-41. DMEV2AL RU https://pubmed.ncbi.nlm.nih.gov/19046886 DMO72XF DI DMO72XF DMO72XF DN KB-130015 DMO72XF MI TTQ6VDM DMO72XF MN Voltage-gated potassium channel Kv11.1 (KCNH2) DMO72XF MT DTT DMO72XF MA Activator DMO72XF RN The amiodarone derivative KB130015 activates hERG1 potassium channels via a novel mechanism. Eur J Pharmacol. 2010 Apr 25;632(1-3):52-9. DMO72XF RU https://pubmed.ncbi.nlm.nih.gov/20097192 DMCQRA3 DI DMCQRA3 DMCQRA3 DN KB-9520 DMCQRA3 MI TTOM3J0 DMCQRA3 MN Estrogen receptor beta (ESR2) DMCQRA3 MT DTT DMCQRA3 MA Agonist DMCQRA3 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 621). DMCQRA3 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=621 DMMD5W3 DI DMMD5W3 DMMD5W3 DN KB-R7943 DMMD5W3 MI TTNVC34 DMMD5W3 MN Short transient receptor potential channel 3 (TRPC3) DMMD5W3 MT DTT DMMD5W3 MA Blocker (channel blocker) DMMD5W3 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 488). DMMD5W3 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=488 DMMD5W3 DI DMMD5W3 DMMD5W3 DN KB-R7943 DMMD5W3 MI TT32NQ1 DMMD5W3 MN Short transient receptor potential channel 5 (TRPC5) DMMD5W3 MT DTT DMMD5W3 MA Blocker (channel blocker) DMMD5W3 RN The Na+/Ca2+ exchange inhibitor KB-R7943 potently blocks TRPC channels. Biochem Biophys Res Commun. 2007 Sep 14;361(1):230-6. DMMD5W3 RU https://pubmed.ncbi.nlm.nih.gov/17658472 DMMD5W3 DI DMMD5W3 DMMD5W3 DN KB-R7943 DMMD5W3 MI TTRBT3W DMMD5W3 MN Short transient receptor potential channel 6 (TRPC6) DMMD5W3 MT DTT DMMD5W3 MA Blocker (channel blocker) DMMD5W3 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 491). DMMD5W3 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=491 DMY6QOR DI DMY6QOR DMY6QOR DN KC-12291 DMY6QOR MI TTZOVE0 DMY6QOR MN Voltage-gated sodium channel alpha Nav1.5 (SCN5A) DMY6QOR MT DTT DMY6QOR MA Inhibitor DMY6QOR RN Sodium late current blockers in ischemia reperfusion: is the bullet magic J Med Chem. 2008 Jul 10;51(13):3856-66. DMY6QOR RU https://pubmed.ncbi.nlm.nih.gov/18529044 DMJ2X64 DI DMJ2X64 DMJ2X64 DN KD-7332 DMJ2X64 MI TTF10I9 DMJ2X64 MN Nitric-oxide synthase inducible (NOS2) DMJ2X64 MT DTT DMJ2X64 MA Inhibitor DMJ2X64 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1250). DMJ2X64 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1250 DMOX8FD DI DMOX8FD DMOX8FD DN KELATORPHAN DMOX8FD MI TTPHMWB DMOX8FD MN Aminopeptidase N (ANPEP) DMOX8FD MT DTT DMOX8FD MA Inhibitor DMOX8FD RN Retro-inverso concept applied to the complete inhibitors of enkephalin-degrading enzymes. J Med Chem. 1988 Sep;31(9):1825-31. DMOX8FD RU https://pubmed.ncbi.nlm.nih.gov/2900898 DMOX8FD DI DMOX8FD DMOX8FD DN KELATORPHAN DMOX8FD MI TT9PBIL DMOX8FD MN Glutamyl aminopeptidase (ENPEP) DMOX8FD MT DTT DMOX8FD MA Inhibitor DMOX8FD RN Retro-inverso concept applied to the complete inhibitors of enkephalin-degrading enzymes. J Med Chem. 1988 Sep;31(9):1825-31. DMOX8FD RU https://pubmed.ncbi.nlm.nih.gov/2900898 DM0RC8M DI DM0RC8M DM0RC8M DN KETOCYCLAZOCINE DM0RC8M MI TTQW87Y DM0RC8M MN Opioid receptor kappa (OPRK1) DM0RC8M MT DTT DM0RC8M MA Inhibitor DM0RC8M RN Syntheses and opioid receptor binding properties of carboxamido-substituted opioids. Bioorg Med Chem Lett. 2009 Jan 1;19(1):203-8. DM0RC8M RU https://pubmed.ncbi.nlm.nih.gov/19027293 DM0RC8M DI DM0RC8M DM0RC8M DN KETOCYCLAZOCINE DM0RC8M MI TTKWM86 DM0RC8M MN Opioid receptor mu (MOP) DM0RC8M MT DTT DM0RC8M MA Inhibitor DM0RC8M RN Syntheses and opioid receptor binding properties of carboxamido-substituted opioids. Bioorg Med Chem Lett. 2009 Jan 1;19(1):203-8. DM0RC8M RU https://pubmed.ncbi.nlm.nih.gov/19027293 DMX2FL3 DI DMX2FL3 DMX2FL3 DN Ketoprofen glucuronide DMX2FL3 MI DE9RA0I DMX2FL3 MN Beta-glucuronidase (uidA) DMX2FL3 MT DME DMX2FL3 MA Metabolism DMX2FL3 RN Bacterial beta-glucuronidase inhibition protects mice against enteropathy induced by indomethacin, ketoprofen or diclofenac: mode of action and pharmacokinetics. Xenobiotica. 2014 Jan;44(1):28-35. DMX2FL3 RU https://pubmed.ncbi.nlm.nih.gov/23829165 DM7W9MT DI DM7W9MT DM7W9MT DN KF 17837S DM7W9MT MI TTNE7KG DM7W9MT MN Adenosine A2b receptor (ADORA2B) DM7W9MT MT DTT DM7W9MT MA Antagonist DM7W9MT RN Characterization of human A2A adenosine receptors with the antagonist radioligand [3H]-SCH 58261. Br J Pharmacol. 1997 Jun;121(3):353-60. DM7W9MT RU https://pubmed.ncbi.nlm.nih.gov/9179373 DMK6SMW DI DMK6SMW DMK6SMW DN KF24345 DMK6SMW MI TTLXAKE DMK6SMW MN Solute carrier family 29 member 1 (SLC29A1) DMK6SMW MT DTT DMK6SMW MA Inhibitor DMK6SMW RN Interaction of the novel adenosine uptake inhibitor 3-[1-(6,7-diethoxy-2-morpholinoquinazolin-4-yl)piperidin-4-yl]-1,6-dimethyl-2,4(1H,3H)-quinazol... J Pharmacol Exp Ther. 2004 Mar;308(3):1083-93. DMK6SMW RU https://pubmed.ncbi.nlm.nih.gov/14634039 DMPBDW0 DI DMPBDW0 DMPBDW0 DN KF26777 DMPBDW0 MI TTK25J1 DMPBDW0 MN Adenosine A1 receptor (ADORA1) DMPBDW0 MT DTT DMPBDW0 MA Antagonist DMPBDW0 RN KF26777 (2-(4-bromophenyl)-7,8-dihydro-4-propyl-1H-imidazo[2,1-i]purin-5(4H)-one dihydrochloride), a new potent and selective adenosine A3 receptor antagonist. Eur J Pharmacol. 2002 May 31;444(3):133-41. DMPBDW0 RU https://pubmed.ncbi.nlm.nih.gov/12063073 DMPBDW0 DI DMPBDW0 DMPBDW0 DN KF26777 DMPBDW0 MI TTNE7KG DMPBDW0 MN Adenosine A2b receptor (ADORA2B) DMPBDW0 MT DTT DMPBDW0 MA Antagonist DMPBDW0 RN KF26777 (2-(4-bromophenyl)-7,8-dihydro-4-propyl-1H-imidazo[2,1-i]purin-5(4H)-one dihydrochloride), a new potent and selective adenosine A3 receptor antagonist. Eur J Pharmacol. 2002 May 31;444(3):133-41. DMPBDW0 RU https://pubmed.ncbi.nlm.nih.gov/12063073 DMPBDW0 DI DMPBDW0 DMPBDW0 DN KF26777 DMPBDW0 MI TTJFY5U DMPBDW0 MN Adenosine A3 receptor (ADORA3) DMPBDW0 MT DTT DMPBDW0 MA Antagonist DMPBDW0 RN KF26777 (2-(4-bromophenyl)-7,8-dihydro-4-propyl-1H-imidazo[2,1-i]purin-5(4H)-one dihydrochloride), a new potent and selective adenosine A3 receptor antagonist. Eur J Pharmacol. 2002 May 31;444(3):133-41. DMPBDW0 RU https://pubmed.ncbi.nlm.nih.gov/12063073 DMOUW0A DI DMOUW0A DMOUW0A DN KF-66490 DMOUW0A MI TTZ97H5 DMOUW0A MN Phosphodiesterase 4A (PDE4A) DMOUW0A MT DTT DMOUW0A MA Inhibitor DMOUW0A RN Effect of orally administered KF66490, a phosphodiesterase 4 inhibitor, on dermatitis in mouse models. Int Immunopharmacol. 2009 Jan;9(1):55-62. DMOUW0A RU https://pubmed.ncbi.nlm.nih.gov/18854230 DMOUW0A DI DMOUW0A DMOUW0A DN KF-66490 DMOUW0A MI TTVIAT9 DMOUW0A MN Phosphodiesterase 4B (PDE4B) DMOUW0A MT DTT DMOUW0A MA Inhibitor DMOUW0A RN Effect of orally administered KF66490, a phosphodiesterase 4 inhibitor, on dermatitis in mouse models. Int Immunopharmacol. 2009 Jan;9(1):55-62. DMOUW0A RU https://pubmed.ncbi.nlm.nih.gov/18854230 DMOUW0A DI DMOUW0A DMOUW0A DN KF-66490 DMOUW0A MI TTSKMI8 DMOUW0A MN Phosphodiesterase 4D (PDE4D) DMOUW0A MT DTT DMOUW0A MA Inhibitor DMOUW0A RN Effect of orally administered KF66490, a phosphodiesterase 4 inhibitor, on dermatitis in mouse models. Int Immunopharmacol. 2009 Jan;9(1):55-62. DMOUW0A RU https://pubmed.ncbi.nlm.nih.gov/18854230 DMFBMYG DI DMFBMYG DMFBMYG DN KF-A5 DMFBMYG MI TTAWNKZ DMFBMYG MN Norepinephrine transporter (NET) DMFBMYG MT DTT DMFBMYG MA Inhibitor DMFBMYG RN Design, synthesis, and evaluation of 10-N-substituted acridones as novel chemosensitizers in Plasmodium falciparum. Antimicrob Agents Chemother. 2007 Nov;51(11):4133-40. DMFBMYG RU https://pubmed.ncbi.nlm.nih.gov/17846138 DMFBMYG DI DMFBMYG DMFBMYG DN KF-A5 DMFBMYG MI TT3ROYC DMFBMYG MN Serotonin transporter (SERT) DMFBMYG MT DTT DMFBMYG MA Inhibitor DMFBMYG RN Design, synthesis, and evaluation of 10-N-substituted acridones as novel chemosensitizers in Plasmodium falciparum. Antimicrob Agents Chemother. 2007 Nov;51(11):4133-40. DMFBMYG RU https://pubmed.ncbi.nlm.nih.gov/17846138 DMQJ3T5 DI DMQJ3T5 DMQJ3T5 DN KF-A6 DMQJ3T5 MI TTTIBOJ DMQJ3T5 MN Histamine H1 receptor (H1R) DMQJ3T5 MT DTT DMQJ3T5 MA Inhibitor DMQJ3T5 RN Design, synthesis, and evaluation of 10-N-substituted acridones as novel chemosensitizers in Plasmodium falciparum. Antimicrob Agents Chemother. 2007 Nov;51(11):4133-40. DMQJ3T5 RU https://pubmed.ncbi.nlm.nih.gov/17846138 DMQJ3T5 DI DMQJ3T5 DMQJ3T5 DN KF-A6 DMQJ3T5 MI TT3ROYC DMQJ3T5 MN Serotonin transporter (SERT) DMQJ3T5 MT DTT DMQJ3T5 MA Inhibitor DMQJ3T5 RN Design, synthesis, and evaluation of 10-N-substituted acridones as novel chemosensitizers in Plasmodium falciparum. Antimicrob Agents Chemother. 2007 Nov;51(11):4133-40. DMQJ3T5 RU https://pubmed.ncbi.nlm.nih.gov/17846138 DMCE8Q9 DI DMCE8Q9 DMCE8Q9 DN KH-164 DMCE8Q9 MI TT5FNQT DMCE8Q9 MN Human immunodeficiency virus Protease (HIV PR) DMCE8Q9 MT DTT DMCE8Q9 MA Modulator DMCE8Q9 RN Impeded progression of Friend disease in mice by an inhibitor of retroviral proteases. J Acquir Immune Defic Syndr. 1993 Jan;6(1):24-31. DMCE8Q9 RU https://www.ncbi.nlm.nih.gov/pubmed/8093263 DMSOB3U DI DMSOB3U DMSOB3U DN KH-CB19 DMSOB3U MI TTE6YDG DMSOB3U MN CDC-like kinase 1 (CLK1) DMSOB3U MT DTT DMSOB3U MA Inhibitor DMSOB3U RN Specific CLK inhibitors from a novel chemotype for regulation of alternative splicing. Chem Biol. 2011 Jan 28;18(1):67-76. DMSOB3U RU https://pubmed.ncbi.nlm.nih.gov/21276940 DMSOB3U DI DMSOB3U DMSOB3U DN KH-CB19 DMSOB3U MI TTQPE1U DMSOB3U MN CDC-like kinase 3 (CLK3) DMSOB3U MT DTT DMSOB3U MA Inhibitor DMSOB3U RN Specific CLK inhibitors from a novel chemotype for regulation of alternative splicing. Chem Biol. 2011 Jan 28;18(1):67-76. DMSOB3U RU https://pubmed.ncbi.nlm.nih.gov/21276940 DMSOB3U DI DMSOB3U DMSOB3U DN KH-CB19 DMSOB3U MI TTSBVFO DMSOB3U MN Dual-specificity tyrosine-phosphorylation regulated kinase 1A (DYRK1A) DMSOB3U MT DTT DMSOB3U MA Inhibitor DMSOB3U RN Specific CLK inhibitors from a novel chemotype for regulation of alternative splicing. Chem Biol. 2011 Jan 28;18(1):67-76. DMSOB3U RU https://pubmed.ncbi.nlm.nih.gov/21276940 DMLG2EA DI DMLG2EA DMLG2EA DN Ki-11502 DMLG2EA MI TTI7421 DMLG2EA MN Platelet-derived growth factor receptor beta (PDGFRB) DMLG2EA MT DTT DMLG2EA MA Inhibitor DMLG2EA RN Identification of potent and selective inhibitors of PDGF receptor autophosphorylation. J Med Chem. 2006 Apr 6;49(7):2186-92. DMLG2EA RU https://pubmed.ncbi.nlm.nih.gov/16570914 DMJTDK9 DI DMJTDK9 DMJTDK9 DN Ki16425 DMJTDK9 MI TTO897C DMJTDK9 MN G protein coupled receptor 87 (GPR87) DMJTDK9 MT DTT DMJTDK9 MA Antagonist DMJTDK9 RN The orphan GPCR GPR87 was deorphanized and shown to be a lysophosphatidic acid receptor. Biochem Biophys Res Commun. 2007 Nov 23;363(3):861-6. DMJTDK9 RU https://pubmed.ncbi.nlm.nih.gov/17905198 DMJTDK9 DI DMJTDK9 DMJTDK9 DN Ki16425 DMJTDK9 MI TTE2YJR DMJTDK9 MN Lysophosphatidate-3 receptor (LPAR3) DMJTDK9 MT DTT DMJTDK9 MA Antagonist DMJTDK9 RN Ki16425, a subtype-selective antagonist for EDG-family lysophosphatidic acid receptors. Mol Pharmacol. 2003 Oct;64(4):994-1005. DMJTDK9 RU https://pubmed.ncbi.nlm.nih.gov/14500756 DMJTDK9 DI DMJTDK9 DMJTDK9 DN Ki16425 DMJTDK9 MI TTQ6S1K DMJTDK9 MN Lysophosphatidic acid receptor 1 (LPAR1) DMJTDK9 MT DTT DMJTDK9 MA Antagonist DMJTDK9 RN Targeting lysophosphatidic acid receptor type 1 with Debio 0719 inhibits spontaneous metastasis dissemination of breast cancer cells independently of cell proliferation and angiogenesis. Int J Oncol. 2012 Apr;40(4):1133-41. DMJTDK9 RU https://pubmed.ncbi.nlm.nih.gov/22200658 DMJTDK9 DI DMJTDK9 DMJTDK9 DN Ki16425 DMJTDK9 MI TTB7Y8I DMJTDK9 MN Lysophosphatidic acid receptor 2 (LPAR2) DMJTDK9 MT DTT DMJTDK9 MA Antagonist DMJTDK9 RN Ki16425, a subtype-selective antagonist for EDG-family lysophosphatidic acid receptors. Mol Pharmacol. 2003 Oct;64(4):994-1005. DMJTDK9 RU https://pubmed.ncbi.nlm.nih.gov/14500756 DM9M3VC DI DM9M3VC DM9M3VC DN Ki-20227 DM9M3VC MI TTVW6QL DM9M3VC MN CSF1R messenger RNA (CSF1R mRNA) DM9M3VC MT DTT DM9M3VC MA Inhibitor DM9M3VC RN Comprehensive analysis of kinase inhibitor selectivity. Nat Biotechnol. 2011 Oct 30;29(11):1046-51. DM9M3VC RU https://pubmed.ncbi.nlm.nih.gov/22037378 DM9M3VC DI DM9M3VC DM9M3VC DN Ki-20227 DM9M3VC MI TTI7421 DM9M3VC MN Platelet-derived growth factor receptor beta (PDGFRB) DM9M3VC MT DTT DM9M3VC MA Inhibitor DM9M3VC RN A c-fms tyrosine kinase inhibitor, Ki20227, suppresses osteoclast differentiation and osteolytic bone destruction in a bone metastasis model. Mol Cancer Ther. 2006 Nov;5(11):2634-43. DM9M3VC RU https://pubmed.ncbi.nlm.nih.gov/17121910 DM9M3VC DI DM9M3VC DM9M3VC DN Ki-20227 DM9M3VC MI TTX41N9 DM9M3VC MN Tyrosine-protein kinase Kit (KIT) DM9M3VC MT DTT DM9M3VC MA Inhibitor DM9M3VC RN A c-fms tyrosine kinase inhibitor, Ki20227, suppresses osteoclast differentiation and osteolytic bone destruction in a bone metastasis model. Mol Cancer Ther. 2006 Nov;5(11):2634-43. DM9M3VC RU https://pubmed.ncbi.nlm.nih.gov/17121910 DM9M3VC DI DM9M3VC DM9M3VC DN Ki-20227 DM9M3VC MI TTUTJGQ DM9M3VC MN Vascular endothelial growth factor receptor 2 (KDR) DM9M3VC MT DTT DM9M3VC MA Inhibitor DM9M3VC RN A c-fms tyrosine kinase inhibitor, Ki20227, suppresses osteoclast differentiation and osteolytic bone destruction in a bone metastasis model. Mol Cancer Ther. 2006 Nov;5(11):2634-43. DM9M3VC RU https://pubmed.ncbi.nlm.nih.gov/17121910 DMHEOBY DI DMHEOBY DMHEOBY DN KIN-3031 DMHEOBY MI TTKWM86 DMHEOBY MN Opioid receptor mu (MOP) DMHEOBY MT DTT DMHEOBY MA Modulator DMHEOBY RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 319). DMHEOBY RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=319 DMO8JQM DI DMO8JQM DMO8JQM DN KIN-4044 DMO8JQM MI TTKWM86 DMO8JQM MN Opioid receptor mu (MOP) DMO8JQM MT DTT DMO8JQM MA Antagonist DMO8JQM RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 319). DMO8JQM RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=319 DMDL21W DI DMDL21W DMDL21W DN kisspeptin-10 DMDL21W MI TT3KBZY DMDL21W MN G-protein coupled receptor 54 (KISS1R) DMDL21W MT DTT DMDL21W MA Agonist DMDL21W RN The metastasis suppressor gene KiSS-1 encodes kisspeptins, the natural ligands of the orphan G protein-coupled receptor GPR54. J Biol Chem. 2001 Sep 14;276(37):34631-6. DMDL21W RU https://pubmed.ncbi.nlm.nih.gov/11457843 DMPJKBV DI DMPJKBV DMPJKBV DN KJM429 DMPJKBV MI TTMI6F5 DMPJKBV MN Transient receptor potential cation channel V1 (TRPV1) DMPJKBV MT DTT DMPJKBV MA Antagonist DMPJKBV RN High affinity antagonists of the vanilloid receptor. Mol Pharmacol. 2002 Oct;62(4):947-56. DMPJKBV RU https://pubmed.ncbi.nlm.nih.gov/12237342 DMAU1SZ DI DMAU1SZ DMAU1SZ DN KKHT-10318 DMAU1SZ MI TT729IR DMAU1SZ MN Voltage-gated calcium channel alpha Cav3.1 (CACNA1G) DMAU1SZ MT DTT DMAU1SZ MA Inhibitor DMAU1SZ RN Novel T-type calcium channel blockers: dioxoquinazoline carboxamide derivatives. Bioorg Med Chem. 2007 Jan 1;15(1):365-73. DMAU1SZ RU https://pubmed.ncbi.nlm.nih.gov/17035033 DMYT381 DI DMYT381 DMYT381 DN KKHT-10608 DMYT381 MI TT729IR DMYT381 MN Voltage-gated calcium channel alpha Cav3.1 (CACNA1G) DMYT381 MT DTT DMYT381 MA Inhibitor DMYT381 RN Novel T-type calcium channel blockers: dioxoquinazoline carboxamide derivatives. Bioorg Med Chem. 2007 Jan 1;15(1):365-73. DMYT381 RU https://pubmed.ncbi.nlm.nih.gov/17035033 DMMI1H0 DI DMMI1H0 DMMI1H0 DN KKHT-10609 DMMI1H0 MI TT729IR DMMI1H0 MN Voltage-gated calcium channel alpha Cav3.1 (CACNA1G) DMMI1H0 MT DTT DMMI1H0 MA Inhibitor DMMI1H0 RN Novel T-type calcium channel blockers: dioxoquinazoline carboxamide derivatives. Bioorg Med Chem. 2007 Jan 1;15(1):365-73. DMMI1H0 RU https://pubmed.ncbi.nlm.nih.gov/17035033 DM1H5TO DI DM1H5TO DM1H5TO DN KKHT-10613 DM1H5TO MI TT729IR DM1H5TO MN Voltage-gated calcium channel alpha Cav3.1 (CACNA1G) DM1H5TO MT DTT DM1H5TO MA Inhibitor DM1H5TO RN Novel T-type calcium channel blockers: dioxoquinazoline carboxamide derivatives. Bioorg Med Chem. 2007 Jan 1;15(1):365-73. DM1H5TO RU https://pubmed.ncbi.nlm.nih.gov/17035033 DMW704S DI DMW704S DMW704S DN KKHT-10618 DMW704S MI TT729IR DMW704S MN Voltage-gated calcium channel alpha Cav3.1 (CACNA1G) DMW704S MT DTT DMW704S MA Inhibitor DMW704S RN Novel T-type calcium channel blockers: dioxoquinazoline carboxamide derivatives. Bioorg Med Chem. 2007 Jan 1;15(1):365-73. DMW704S RU https://pubmed.ncbi.nlm.nih.gov/17035033 DM4F96I DI DM4F96I DM4F96I DN KKHT-11018 DM4F96I MI TT729IR DM4F96I MN Voltage-gated calcium channel alpha Cav3.1 (CACNA1G) DM4F96I MT DTT DM4F96I MA Inhibitor DM4F96I RN Novel T-type calcium channel blockers: dioxoquinazoline carboxamide derivatives. Bioorg Med Chem. 2007 Jan 1;15(1):365-73. DM4F96I RU https://pubmed.ncbi.nlm.nih.gov/17035033 DMLB4TU DI DMLB4TU DMLB4TU DN KKHT-20718 DMLB4TU MI TT729IR DMLB4TU MN Voltage-gated calcium channel alpha Cav3.1 (CACNA1G) DMLB4TU MT DTT DMLB4TU MA Inhibitor DMLB4TU RN Novel T-type calcium channel blockers: dioxoquinazoline carboxamide derivatives. Bioorg Med Chem. 2007 Jan 1;15(1):365-73. DMLB4TU RU https://pubmed.ncbi.nlm.nih.gov/17035033 DMP1A3C DI DMP1A3C DMP1A3C DN KKHT-20818 DMP1A3C MI TT729IR DMP1A3C MN Voltage-gated calcium channel alpha Cav3.1 (CACNA1G) DMP1A3C MT DTT DMP1A3C MA Inhibitor DMP1A3C RN Novel T-type calcium channel blockers: dioxoquinazoline carboxamide derivatives. Bioorg Med Chem. 2007 Jan 1;15(1):365-73. DMP1A3C RU https://pubmed.ncbi.nlm.nih.gov/17035033 DMTW4Q1 DI DMTW4Q1 DMTW4Q1 DN KKHT-20918 DMTW4Q1 MI TT729IR DMTW4Q1 MN Voltage-gated calcium channel alpha Cav3.1 (CACNA1G) DMTW4Q1 MT DTT DMTW4Q1 MA Inhibitor DMTW4Q1 RN Novel T-type calcium channel blockers: dioxoquinazoline carboxamide derivatives. Bioorg Med Chem. 2007 Jan 1;15(1):365-73. DMTW4Q1 RU https://pubmed.ncbi.nlm.nih.gov/17035033 DMG3FDE DI DMG3FDE DMG3FDE DN KL044 DMG3FDE MI TT5MLZR DMG3FDE MN Cryptochrome circadian clock 1 (CRY1) DMG3FDE MT DTT DMG3FDE MA Modulator DMG3FDE RN Development of Small-Molecule Cryptochrome Stabilizer Derivatives as Modulators of the Circadian Clock. ChemMedChem. 2015 Sep;10(9):1489-97. DMG3FDE RU https://pubmed.ncbi.nlm.nih.gov/26174033 DMG594K DI DMG594K DMG594K DN KM-01221 DMG594K MI TT8VUE0 DMG594K MN Chymase (CYM) DMG594K MT DTT DMG594K MA Inhibitor DMG594K RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2340). DMG594K RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2340 DMZSYKC DI DMZSYKC DMZSYKC DN KM-233 DMZSYKC MI TT6OEDT DMZSYKC MN Cannabinoid receptor 1 (CB1) DMZSYKC MT DTT DMZSYKC MA Inhibitor DMZSYKC RN Exploring the substituent effects on a novel series of C1'-dimethyl-aryl Delta8-tetrahydrocannabinol analogs. Bioorg Med Chem. 2008 Jul 1;16(13):6489-500. DMZSYKC RU https://pubmed.ncbi.nlm.nih.gov/18524604 DMZSYKC DI DMZSYKC DMZSYKC DN KM-233 DMZSYKC MI TTMSFAW DMZSYKC MN Cannabinoid receptor 2 (CB2) DMZSYKC MT DTT DMZSYKC MA Inhibitor DMZSYKC RN Exploring the substituent effects on a novel series of C1'-dimethyl-aryl Delta8-tetrahydrocannabinol analogs. Bioorg Med Chem. 2008 Jul 1;16(13):6489-500. DMZSYKC RU https://pubmed.ncbi.nlm.nih.gov/18524604 DMK4IBO DI DMK4IBO DMK4IBO DN KM-233-M DMK4IBO MI TT6OEDT DMK4IBO MN Cannabinoid receptor 1 (CB1) DMK4IBO MT DTT DMK4IBO MA Inhibitor DMK4IBO RN Exploring the substituent effects on a novel series of C1'-dimethyl-aryl Delta8-tetrahydrocannabinol analogs. Bioorg Med Chem. 2008 Jul 1;16(13):6489-500. DMK4IBO RU https://pubmed.ncbi.nlm.nih.gov/18524604 DMK4IBO DI DMK4IBO DMK4IBO DN KM-233-M DMK4IBO MI TTMSFAW DMK4IBO MN Cannabinoid receptor 2 (CB2) DMK4IBO MT DTT DMK4IBO MA Inhibitor DMK4IBO RN Exploring the substituent effects on a novel series of C1'-dimethyl-aryl Delta8-tetrahydrocannabinol analogs. Bioorg Med Chem. 2008 Jul 1;16(13):6489-500. DMK4IBO RU https://pubmed.ncbi.nlm.nih.gov/18524604 DMK17GN DI DMK17GN DMK17GN DN KM-4056 DMK17GN MI TTTSGRH DMK17GN MN Leucine-rich repeat-containing GPCR 5 (LGR5) DMK17GN MT DTT DMK17GN RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 148). DMK17GN RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=148 DMLRVEJ DI DMLRVEJ DMLRVEJ DN KMI-172 DMLRVEJ MI TT8JRS7 DMLRVEJ MN Beta-secretase (BACE) DMLRVEJ MT DTT DMLRVEJ MA Inhibitor DMLRVEJ RN Design and synthesis of BACE1 inhibitors containing a novel norstatine derivative (2R,3R)-3-amino-2-hydroxy-4-(phenylthio)butyric acid. Bioorg Med Chem Lett. 2007 Mar 15;17(6):1629-33. DMLRVEJ RU https://pubmed.ncbi.nlm.nih.gov/17251016 DMQ4WNB DI DMQ4WNB DMQ4WNB DN KMI-494 DMQ4WNB MI TT8JRS7 DMQ4WNB MN Beta-secretase (BACE) DMQ4WNB MT DTT DMQ4WNB MA Inhibitor DMQ4WNB RN Design and synthesis of BACE1 inhibitors containing a novel norstatine derivative (2R,3R)-3-amino-2-hydroxy-4-(phenylthio)butyric acid. Bioorg Med Chem Lett. 2007 Mar 15;17(6):1629-33. DMQ4WNB RU https://pubmed.ncbi.nlm.nih.gov/17251016 DMX9EA7 DI DMX9EA7 DMX9EA7 DN KMI-538 DMX9EA7 MI TT8JRS7 DMX9EA7 MN Beta-secretase (BACE) DMX9EA7 MT DTT DMX9EA7 MA Inhibitor DMX9EA7 RN Design and synthesis of BACE1 inhibitors containing a novel norstatine derivative (2R,3R)-3-amino-2-hydroxy-4-(phenylthio)butyric acid. Bioorg Med Chem Lett. 2007 Mar 15;17(6):1629-33. DMX9EA7 RU https://pubmed.ncbi.nlm.nih.gov/17251016 DMXUETW DI DMXUETW DMXUETW DN KMI-596 DMXUETW MI TT8JRS7 DMXUETW MN Beta-secretase (BACE) DMXUETW MT DTT DMXUETW MA Inhibitor DMXUETW RN Design of pentapeptidic BACE1 inhibitors with carboxylic acid bioisosteres at P1' and P4 positions. Bioorg Med Chem. 2010 May 1;18(9):3175-86. DMXUETW RU https://pubmed.ncbi.nlm.nih.gov/20381362 DMP1GQB DI DMP1GQB DMP1GQB DN KMJ-372 DMP1GQB MI TTMI6F5 DMP1GQB MN Transient receptor potential cation channel V1 (TRPV1) DMP1GQB MT DTT DMP1GQB MA Antagonist DMP1GQB RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 507). DMP1GQB RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=507 DMFVS16 DI DMFVS16 DMFVS16 DN KML110 DMFVS16 MI TT6A5ZL DMFVS16 MN Nucleobindin-1 (NUCB1) DMFVS16 MT DTT DMFVS16 MA Antagonist DMFVS16 RN A Global Map of Lipid-Binding Proteins and Their Ligandability in Cells. Cell. 2015 Jun 18;161(7):1668-80. DMFVS16 RU https://pubmed.ncbi.nlm.nih.gov/26091042 DM2K81B DI DM2K81B DM2K81B DN KMS-88009 DM2K81B MI TTE4KHA DM2K81B MN Amyloid beta A4 protein (APP) DM2K81B MT DTT DM2K81B MA Inhibitor DM2K81B RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2402). DM2K81B RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2402 DMLZ89P DI DMLZ89P DMLZ89P DN KN-62 DMLZ89P MI TTTU902 DMLZ89P MN Checkpoint kinase-1 (CHK1) DMLZ89P MT DTT DMLZ89P MA Inhibitor DMLZ89P RN Specificity and mechanism of action of some commonly used protein kinase inhibitors. Biochem J. 2000 Oct 1;351(Pt 1):95-105. DMLZ89P RU https://pubmed.ncbi.nlm.nih.gov/10998351 DMLZ89P DI DMLZ89P DMLZ89P DN KN-62 DMLZ89P MI TT4TQBX DMLZ89P MN Extracellular signal-regulated kinase 2 (ERK2) DMLZ89P MT DTT DMLZ89P MA Inhibitor DMLZ89P RN Specificity and mechanism of action of some commonly used protein kinase inhibitors. Biochem J. 2000 Oct 1;351(Pt 1):95-105. DMLZ89P RU https://pubmed.ncbi.nlm.nih.gov/10998351 DMLZ89P DI DMLZ89P DMLZ89P DN KN-62 DMLZ89P MI TT860QF DMLZ89P MN LCK tyrosine protein kinase (LCK) DMLZ89P MT DTT DMLZ89P MA Inhibitor DMLZ89P RN Specificity and mechanism of action of some commonly used protein kinase inhibitors. Biochem J. 2000 Oct 1;351(Pt 1):95-105. DMLZ89P RU https://pubmed.ncbi.nlm.nih.gov/10998351 DMLZ89P DI DMLZ89P DMLZ89P DN KN-62 DMLZ89P MI TTYT93M DMLZ89P MN MAP kinase p38 (MAPK12) DMLZ89P MT DTT DMLZ89P MA Inhibitor DMLZ89P RN Specificity and mechanism of action of some commonly used protein kinase inhibitors. Biochem J. 2000 Oct 1;351(Pt 1):95-105. DMLZ89P RU https://pubmed.ncbi.nlm.nih.gov/10998351 DMLZ89P DI DMLZ89P DMLZ89P DN KN-62 DMLZ89P MI TT473XN DMLZ89P MN P2X purinoceptor 7 (P2RX7) DMLZ89P MT DTT DMLZ89P MA Inhibitor DMLZ89P RN Synthesis and structure-activity relationships of pyrazolodiazepine derivatives as human P2X7 receptor antagonists. Bioorg Med Chem Lett. 2009 Nov 1;19(21):6053-8. DMLZ89P RU https://pubmed.ncbi.nlm.nih.gov/19800793 DMLZ89P DI DMLZ89P DMLZ89P DN KN-62 DMLZ89P MI TTFJ8Q1 DMLZ89P MN Protein kinase C alpha (PRKCA) DMLZ89P MT DTT DMLZ89P MA Inhibitor DMLZ89P RN Specificity and mechanism of action of some commonly used protein kinase inhibitors. Biochem J. 2000 Oct 1;351(Pt 1):95-105. DMLZ89P RU https://pubmed.ncbi.nlm.nih.gov/10998351 DMLZ89P DI DMLZ89P DMLZ89P DN KN-62 DMLZ89P MI TTWTSCV DMLZ89P MN RAC-alpha serine/threonine-protein kinase (AKT1) DMLZ89P MT DTT DMLZ89P MA Inhibitor DMLZ89P RN Specificity and mechanism of action of some commonly used protein kinase inhibitors. Biochem J. 2000 Oct 1;351(Pt 1):95-105. DMLZ89P RU https://pubmed.ncbi.nlm.nih.gov/10998351 DMLZ89P DI DMLZ89P DMLZ89P DN KN-62 DMLZ89P MI TTZN7RP DMLZ89P MN Rho-associated protein kinase 1 (ROCK1) DMLZ89P MT DTT DMLZ89P MA Inhibitor DMLZ89P RN Specificity and mechanism of action of some commonly used protein kinase inhibitors. Biochem J. 2000 Oct 1;351(Pt 1):95-105. DMLZ89P RU https://pubmed.ncbi.nlm.nih.gov/10998351 DMLZ89P DI DMLZ89P DMLZ89P DN KN-62 DMLZ89P MI TTG0U4H DMLZ89P MN Ribosomal protein S6 kinase beta-1 (S6K1) DMLZ89P MT DTT DMLZ89P MA Inhibitor DMLZ89P RN Specificity and mechanism of action of some commonly used protein kinase inhibitors. Biochem J. 2000 Oct 1;351(Pt 1):95-105. DMLZ89P RU https://pubmed.ncbi.nlm.nih.gov/10998351 DMLZ89P DI DMLZ89P DMLZ89P DN KN-62 DMLZ89P MI TTTV8EJ DMLZ89P MN Serine/threonine-protein kinase Sgk1 (SGK1) DMLZ89P MT DTT DMLZ89P MA Inhibitor DMLZ89P RN Specificity and mechanism of action of some commonly used protein kinase inhibitors. Biochem J. 2000 Oct 1;351(Pt 1):95-105. DMLZ89P RU https://pubmed.ncbi.nlm.nih.gov/10998351 DMLZ89P DI DMLZ89P DMLZ89P DN KN-62 DMLZ89P MI TTQBR95 DMLZ89P MN Stress-activated protein kinase 2a (p38 alpha) DMLZ89P MT DTT DMLZ89P MA Inhibitor DMLZ89P RN Specificity and mechanism of action of some commonly used protein kinase inhibitors. Biochem J. 2000 Oct 1;351(Pt 1):95-105. DMLZ89P RU https://pubmed.ncbi.nlm.nih.gov/10998351 DMLZ89P DI DMLZ89P DMLZ89P DN KN-62 DMLZ89P MI TT73U6C DMLZ89P MN Stress-activated protein kinase 2b (p38 beta) DMLZ89P MT DTT DMLZ89P MA Inhibitor DMLZ89P RN Specificity and mechanism of action of some commonly used protein kinase inhibitors. Biochem J. 2000 Oct 1;351(Pt 1):95-105. DMLZ89P RU https://pubmed.ncbi.nlm.nih.gov/10998351 DMLZ89P DI DMLZ89P DMLZ89P DN KN-62 DMLZ89P MI TT0K6EO DMLZ89P MN Stress-activated protein kinase JNK1 (JNK1) DMLZ89P MT DTT DMLZ89P MA Inhibitor DMLZ89P RN Specificity and mechanism of action of some commonly used protein kinase inhibitors. Biochem J. 2000 Oct 1;351(Pt 1):95-105. DMLZ89P RU https://pubmed.ncbi.nlm.nih.gov/10998351 DMPTMKH DI DMPTMKH DMPTMKH DN KN-93 DMPTMKH MI TTFYL58 DMPTMKH MN CaM-kinase II (CAMK2) DMPTMKH MT DTT DMPTMKH MA Inhibitor DMPTMKH RN Discovery of a 3-amino-6-phenyl-pyridazine derivative as a new synthetic antineuroinflammatory compound. J Med Chem. 2002 Jan 31;45(3):563-6. DMPTMKH RU https://pubmed.ncbi.nlm.nih.gov/11806708 DMMISH6 DI DMMISH6 DMMISH6 DN KNI-10006 DMMISH6 MI TTPT2QI DMMISH6 MN Cathepsin D (CTSD) DMMISH6 MT DTT DMMISH6 MA Inhibitor DMMISH6 RN alpha-Substituted norstatines as the transition-state mimic in inhibitors of multiple digestive vacuole malaria aspartic proteases. Bioorg Med Chem. 2009 Aug 15;17(16):5933-49. DMMISH6 RU https://pubmed.ncbi.nlm.nih.gov/19635672 DMMISH6 DI DMMISH6 DMMISH6 DN KNI-10006 DMMISH6 MI TTH9VL3 DMMISH6 MN Plasmodium Plasmepsin 1 (Malaria PLA1) DMMISH6 MT DTT DMMISH6 MA Inhibitor DMMISH6 RN alpha-Substituted norstatines as the transition-state mimic in inhibitors of multiple digestive vacuole malaria aspartic proteases. Bioorg Med Chem. 2009 Aug 15;17(16):5933-49. DMMISH6 RU https://pubmed.ncbi.nlm.nih.gov/19635672 DMMISH6 DI DMMISH6 DMMISH6 DN KNI-10006 DMMISH6 MI TTXMNHO DMMISH6 MN Plasmodium Plasmepsin 2 (Malaria PLA2) DMMISH6 MT DTT DMMISH6 MA Inhibitor DMMISH6 RN Improvement of both plasmepsin inhibitory activity and antimalarial activity by 2-aminoethylamino substitution. Bioorg Med Chem Lett. 2010 Aug 15;20(16):4836-9. DMMISH6 RU https://pubmed.ncbi.nlm.nih.gov/20634066 DMLOXMQ DI DMLOXMQ DMLOXMQ DN KNI-10033 DMLOXMQ MI TTXMNHO DMLOXMQ MN Plasmodium Plasmepsin 2 (Malaria PLA2) DMLOXMQ MT DTT DMLOXMQ MA Inhibitor DMLOXMQ RN Additional interaction of allophenylnorstatine-containing tripeptidomimetics with malarial aspartic protease plasmepsin II. Bioorg Med Chem Lett. 2007 Jun 1;17(11):3048-52. DMLOXMQ RU https://pubmed.ncbi.nlm.nih.gov/17400453 DMMZ6AO DI DMMZ6AO DMMZ6AO DN KNI-10061 DMMZ6AO MI TTXMNHO DMMZ6AO MN Plasmodium Plasmepsin 2 (Malaria PLA2) DMMZ6AO MT DTT DMMZ6AO MA Inhibitor DMMZ6AO RN Additional interaction of allophenylnorstatine-containing tripeptidomimetics with malarial aspartic protease plasmepsin II. Bioorg Med Chem Lett. 2007 Jun 1;17(11):3048-52. DMMZ6AO RU https://pubmed.ncbi.nlm.nih.gov/17400453 DMYSDN4 DI DMYSDN4 DMYSDN4 DN KNI-10062 DMYSDN4 MI TTXMNHO DMYSDN4 MN Plasmodium Plasmepsin 2 (Malaria PLA2) DMYSDN4 MT DTT DMYSDN4 MA Inhibitor DMYSDN4 RN Additional interaction of allophenylnorstatine-containing tripeptidomimetics with malarial aspartic protease plasmepsin II. Bioorg Med Chem Lett. 2007 Jun 1;17(11):3048-52. DMYSDN4 RU https://pubmed.ncbi.nlm.nih.gov/17400453 DMM5SDT DI DMM5SDT DMM5SDT DN KNI-10074 DMM5SDT MI TTXMNHO DMM5SDT MN Plasmodium Plasmepsin 2 (Malaria PLA2) DMM5SDT MT DTT DMM5SDT MA Inhibitor DMM5SDT RN Antimalarial activity enhancement in hydroxymethylcarbonyl (HMC) isostere-based dipeptidomimetics targeting malarial aspartic protease plasmepsin. Bioorg Med Chem. 2008 Dec 1;16(23):10049-60. DMM5SDT RU https://pubmed.ncbi.nlm.nih.gov/18952439 DMCZOX9 DI DMCZOX9 DMCZOX9 DN KNI-10079 DMCZOX9 MI TTXMNHO DMCZOX9 MN Plasmodium Plasmepsin 2 (Malaria PLA2) DMCZOX9 MT DTT DMCZOX9 MA Inhibitor DMCZOX9 RN Antimalarial activity enhancement in hydroxymethylcarbonyl (HMC) isostere-based dipeptidomimetics targeting malarial aspartic protease plasmepsin. Bioorg Med Chem. 2008 Dec 1;16(23):10049-60. DMCZOX9 RU https://pubmed.ncbi.nlm.nih.gov/18952439 DMEN4DZ DI DMEN4DZ DMEN4DZ DN KNI-10080 DMEN4DZ MI TTXMNHO DMEN4DZ MN Plasmodium Plasmepsin 2 (Malaria PLA2) DMEN4DZ MT DTT DMEN4DZ MA Inhibitor DMEN4DZ RN Antimalarial activity enhancement in hydroxymethylcarbonyl (HMC) isostere-based dipeptidomimetics targeting malarial aspartic protease plasmepsin. Bioorg Med Chem. 2008 Dec 1;16(23):10049-60. DMEN4DZ RU https://pubmed.ncbi.nlm.nih.gov/18952439 DM1Z7QK DI DM1Z7QK DM1Z7QK DN KNI-10081 DM1Z7QK MI TTXMNHO DM1Z7QK MN Plasmodium Plasmepsin 2 (Malaria PLA2) DM1Z7QK MT DTT DM1Z7QK MA Inhibitor DM1Z7QK RN Antimalarial activity enhancement in hydroxymethylcarbonyl (HMC) isostere-based dipeptidomimetics targeting malarial aspartic protease plasmepsin. Bioorg Med Chem. 2008 Dec 1;16(23):10049-60. DM1Z7QK RU https://pubmed.ncbi.nlm.nih.gov/18952439 DMYN2U4 DI DMYN2U4 DMYN2U4 DN KNI-10087 DMYN2U4 MI TTXMNHO DMYN2U4 MN Plasmodium Plasmepsin 2 (Malaria PLA2) DMYN2U4 MT DTT DMYN2U4 MA Inhibitor DMYN2U4 RN Antimalarial activity enhancement in hydroxymethylcarbonyl (HMC) isostere-based dipeptidomimetics targeting malarial aspartic protease plasmepsin. Bioorg Med Chem. 2008 Dec 1;16(23):10049-60. DMYN2U4 RU https://pubmed.ncbi.nlm.nih.gov/18952439 DM4GASE DI DM4GASE DM4GASE DN KNI-10088 DM4GASE MI TTXMNHO DM4GASE MN Plasmodium Plasmepsin 2 (Malaria PLA2) DM4GASE MT DTT DM4GASE MA Inhibitor DM4GASE RN Antimalarial activity enhancement in hydroxymethylcarbonyl (HMC) isostere-based dipeptidomimetics targeting malarial aspartic protease plasmepsin. Bioorg Med Chem. 2008 Dec 1;16(23):10049-60. DM4GASE RU https://pubmed.ncbi.nlm.nih.gov/18952439 DMV1KI2 DI DMV1KI2 DMV1KI2 DN KNI-10092 DMV1KI2 MI TTXMNHO DMV1KI2 MN Plasmodium Plasmepsin 2 (Malaria PLA2) DMV1KI2 MT DTT DMV1KI2 MA Inhibitor DMV1KI2 RN Antimalarial activity enhancement in hydroxymethylcarbonyl (HMC) isostere-based dipeptidomimetics targeting malarial aspartic protease plasmepsin. Bioorg Med Chem. 2008 Dec 1;16(23):10049-60. DMV1KI2 RU https://pubmed.ncbi.nlm.nih.gov/18952439 DMGY5Z0 DI DMGY5Z0 DMGY5Z0 DN KNI-10093 DMGY5Z0 MI TTXMNHO DMGY5Z0 MN Plasmodium Plasmepsin 2 (Malaria PLA2) DMGY5Z0 MT DTT DMGY5Z0 MA Inhibitor DMGY5Z0 RN Antimalarial activity enhancement in hydroxymethylcarbonyl (HMC) isostere-based dipeptidomimetics targeting malarial aspartic protease plasmepsin. Bioorg Med Chem. 2008 Dec 1;16(23):10049-60. DMGY5Z0 RU https://pubmed.ncbi.nlm.nih.gov/18952439 DMJIQG2 DI DMJIQG2 DMJIQG2 DN KNI-10094 DMJIQG2 MI TTXMNHO DMJIQG2 MN Plasmodium Plasmepsin 2 (Malaria PLA2) DMJIQG2 MT DTT DMJIQG2 MA Inhibitor DMJIQG2 RN Antimalarial activity enhancement in hydroxymethylcarbonyl (HMC) isostere-based dipeptidomimetics targeting malarial aspartic protease plasmepsin. Bioorg Med Chem. 2008 Dec 1;16(23):10049-60. DMJIQG2 RU https://pubmed.ncbi.nlm.nih.gov/18952439 DMEHPVF DI DMEHPVF DMEHPVF DN KNI-10095 DMEHPVF MI TTXMNHO DMEHPVF MN Plasmodium Plasmepsin 2 (Malaria PLA2) DMEHPVF MT DTT DMEHPVF MA Inhibitor DMEHPVF RN Antimalarial activity enhancement in hydroxymethylcarbonyl (HMC) isostere-based dipeptidomimetics targeting malarial aspartic protease plasmepsin. Bioorg Med Chem. 2008 Dec 1;16(23):10049-60. DMEHPVF RU https://pubmed.ncbi.nlm.nih.gov/18952439 DMBTRHG DI DMBTRHG DMBTRHG DN KNI-10106 DMBTRHG MI TTXMNHO DMBTRHG MN Plasmodium Plasmepsin 2 (Malaria PLA2) DMBTRHG MT DTT DMBTRHG MA Inhibitor DMBTRHG RN Antimalarial activity enhancement in hydroxymethylcarbonyl (HMC) isostere-based dipeptidomimetics targeting malarial aspartic protease plasmepsin. Bioorg Med Chem. 2008 Dec 1;16(23):10049-60. DMBTRHG RU https://pubmed.ncbi.nlm.nih.gov/18952439 DM78A6F DI DM78A6F DM78A6F DN KNI-10113 DM78A6F MI TTXMNHO DM78A6F MN Plasmodium Plasmepsin 2 (Malaria PLA2) DM78A6F MT DTT DM78A6F MA Inhibitor DM78A6F RN Antimalarial activity enhancement in hydroxymethylcarbonyl (HMC) isostere-based dipeptidomimetics targeting malarial aspartic protease plasmepsin. Bioorg Med Chem. 2008 Dec 1;16(23):10049-60. DM78A6F RU https://pubmed.ncbi.nlm.nih.gov/18952439 DMA9104 DI DMA9104 DMA9104 DN KNI-10124 DMA9104 MI TTXMNHO DMA9104 MN Plasmodium Plasmepsin 2 (Malaria PLA2) DMA9104 MT DTT DMA9104 MA Inhibitor DMA9104 RN Antimalarial activity enhancement in hydroxymethylcarbonyl (HMC) isostere-based dipeptidomimetics targeting malarial aspartic protease plasmepsin. Bioorg Med Chem. 2008 Dec 1;16(23):10049-60. DMA9104 RU https://pubmed.ncbi.nlm.nih.gov/18952439 DMDBERC DI DMDBERC DMDBERC DN KNI-10125 DMDBERC MI TTXMNHO DMDBERC MN Plasmodium Plasmepsin 2 (Malaria PLA2) DMDBERC MT DTT DMDBERC MA Inhibitor DMDBERC RN Antimalarial activity enhancement in hydroxymethylcarbonyl (HMC) isostere-based dipeptidomimetics targeting malarial aspartic protease plasmepsin. Bioorg Med Chem. 2008 Dec 1;16(23):10049-60. DMDBERC RU https://pubmed.ncbi.nlm.nih.gov/18952439 DMNBUS4 DI DMNBUS4 DMNBUS4 DN KNI-10152 DMNBUS4 MI TTXMNHO DMNBUS4 MN Plasmodium Plasmepsin 2 (Malaria PLA2) DMNBUS4 MT DTT DMNBUS4 MA Inhibitor DMNBUS4 RN Antimalarial activity enhancement in hydroxymethylcarbonyl (HMC) isostere-based dipeptidomimetics targeting malarial aspartic protease plasmepsin. Bioorg Med Chem. 2008 Dec 1;16(23):10049-60. DMNBUS4 RU https://pubmed.ncbi.nlm.nih.gov/18952439 DM1PKWA DI DM1PKWA DM1PKWA DN KNI-10155 DM1PKWA MI TTXMNHO DM1PKWA MN Plasmodium Plasmepsin 2 (Malaria PLA2) DM1PKWA MT DTT DM1PKWA MA Inhibitor DM1PKWA RN Antimalarial activity enhancement in hydroxymethylcarbonyl (HMC) isostere-based dipeptidomimetics targeting malarial aspartic protease plasmepsin. Bioorg Med Chem. 2008 Dec 1;16(23):10049-60. DM1PKWA RU https://pubmed.ncbi.nlm.nih.gov/18952439 DM64NBG DI DM64NBG DM64NBG DN KNI-10216 DM64NBG MI TTXMNHO DM64NBG MN Plasmodium Plasmepsin 2 (Malaria PLA2) DM64NBG MT DTT DM64NBG MA Inhibitor DM64NBG RN Antimalarial activity enhancement in hydroxymethylcarbonyl (HMC) isostere-based dipeptidomimetics targeting malarial aspartic protease plasmepsin. Bioorg Med Chem. 2008 Dec 1;16(23):10049-60. DM64NBG RU https://pubmed.ncbi.nlm.nih.gov/18952439 DMHLFAE DI DMHLFAE DMHLFAE DN KNI-10217 DMHLFAE MI TTXMNHO DMHLFAE MN Plasmodium Plasmepsin 2 (Malaria PLA2) DMHLFAE MT DTT DMHLFAE MA Inhibitor DMHLFAE RN Antimalarial activity enhancement in hydroxymethylcarbonyl (HMC) isostere-based dipeptidomimetics targeting malarial aspartic protease plasmepsin. Bioorg Med Chem. 2008 Dec 1;16(23):10049-60. DMHLFAE RU https://pubmed.ncbi.nlm.nih.gov/18952439 DMQY1ST DI DMQY1ST DMQY1ST DN KNI-10232 DMQY1ST MI TTXMNHO DMQY1ST MN Plasmodium Plasmepsin 2 (Malaria PLA2) DMQY1ST MT DTT DMQY1ST MA Inhibitor DMQY1ST RN Additional interaction of allophenylnorstatine-containing tripeptidomimetics with malarial aspartic protease plasmepsin II. Bioorg Med Chem Lett. 2007 Jun 1;17(11):3048-52. DMQY1ST RU https://pubmed.ncbi.nlm.nih.gov/17400453 DMV3U9Z DI DMV3U9Z DMV3U9Z DN KNI-10255 DMV3U9Z MI TTXMNHO DMV3U9Z MN Plasmodium Plasmepsin 2 (Malaria PLA2) DMV3U9Z MT DTT DMV3U9Z MA Inhibitor DMV3U9Z RN Antimalarial activity enhancement in hydroxymethylcarbonyl (HMC) isostere-based dipeptidomimetics targeting malarial aspartic protease plasmepsin. Bioorg Med Chem. 2008 Dec 1;16(23):10049-60. DMV3U9Z RU https://pubmed.ncbi.nlm.nih.gov/18952439 DMZFVHT DI DMZFVHT DMZFVHT DN KNI-10256 DMZFVHT MI TTXMNHO DMZFVHT MN Plasmodium Plasmepsin 2 (Malaria PLA2) DMZFVHT MT DTT DMZFVHT MA Inhibitor DMZFVHT RN Antimalarial activity enhancement in hydroxymethylcarbonyl (HMC) isostere-based dipeptidomimetics targeting malarial aspartic protease plasmepsin. Bioorg Med Chem. 2008 Dec 1;16(23):10049-60. DMZFVHT RU https://pubmed.ncbi.nlm.nih.gov/18952439 DMZXI6U DI DMZXI6U DMZXI6U DN KNI-10260 DMZXI6U MI TTXMNHO DMZXI6U MN Plasmodium Plasmepsin 2 (Malaria PLA2) DMZXI6U MT DTT DMZXI6U MA Inhibitor DMZXI6U RN Antimalarial activity enhancement in hydroxymethylcarbonyl (HMC) isostere-based dipeptidomimetics targeting malarial aspartic protease plasmepsin. Bioorg Med Chem. 2008 Dec 1;16(23):10049-60. DMZXI6U RU https://pubmed.ncbi.nlm.nih.gov/18952439 DMQLB3T DI DMQLB3T DMQLB3T DN KNI-10265 DMQLB3T MI TTXMNHO DMQLB3T MN Plasmodium Plasmepsin 2 (Malaria PLA2) DMQLB3T MT DTT DMQLB3T MA Inhibitor DMQLB3T RN Antimalarial activity enhancement in hydroxymethylcarbonyl (HMC) isostere-based dipeptidomimetics targeting malarial aspartic protease plasmepsin. Bioorg Med Chem. 2008 Dec 1;16(23):10049-60. DMQLB3T RU https://pubmed.ncbi.nlm.nih.gov/18952439 DMP2E3I DI DMP2E3I DMP2E3I DN KNI-10266 DMP2E3I MI TTXMNHO DMP2E3I MN Plasmodium Plasmepsin 2 (Malaria PLA2) DMP2E3I MT DTT DMP2E3I MA Inhibitor DMP2E3I RN Antimalarial activity enhancement in hydroxymethylcarbonyl (HMC) isostere-based dipeptidomimetics targeting malarial aspartic protease plasmepsin. Bioorg Med Chem. 2008 Dec 1;16(23):10049-60. DMP2E3I RU https://pubmed.ncbi.nlm.nih.gov/18952439 DMAR35H DI DMAR35H DMAR35H DN KNI-10282 DMAR35H MI TTXMNHO DMAR35H MN Plasmodium Plasmepsin 2 (Malaria PLA2) DMAR35H MT DTT DMAR35H MA Inhibitor DMAR35H RN Antimalarial activity enhancement in hydroxymethylcarbonyl (HMC) isostere-based dipeptidomimetics targeting malarial aspartic protease plasmepsin. Bioorg Med Chem. 2008 Dec 1;16(23):10049-60. DMAR35H RU https://pubmed.ncbi.nlm.nih.gov/18952439 DMGVBIT DI DMGVBIT DMGVBIT DN KNI-10283 DMGVBIT MI TTXMNHO DMGVBIT MN Plasmodium Plasmepsin 2 (Malaria PLA2) DMGVBIT MT DTT DMGVBIT MA Inhibitor DMGVBIT RN Antimalarial activity enhancement in hydroxymethylcarbonyl (HMC) isostere-based dipeptidomimetics targeting malarial aspartic protease plasmepsin. Bioorg Med Chem. 2008 Dec 1;16(23):10049-60. DMGVBIT RU https://pubmed.ncbi.nlm.nih.gov/18952439 DMP7M8O DI DMP7M8O DMP7M8O DN KNI-10313 DMP7M8O MI TTXMNHO DMP7M8O MN Plasmodium Plasmepsin 2 (Malaria PLA2) DMP7M8O MT DTT DMP7M8O MA Inhibitor DMP7M8O RN Additional interaction of allophenylnorstatine-containing tripeptidomimetics with malarial aspartic protease plasmepsin II. Bioorg Med Chem Lett. 2007 Jun 1;17(11):3048-52. DMP7M8O RU https://pubmed.ncbi.nlm.nih.gov/17400453 DMYGNZA DI DMYGNZA DMYGNZA DN KNI-10314 DMYGNZA MI TTXMNHO DMYGNZA MN Plasmodium Plasmepsin 2 (Malaria PLA2) DMYGNZA MT DTT DMYGNZA MA Inhibitor DMYGNZA RN Additional interaction of allophenylnorstatine-containing tripeptidomimetics with malarial aspartic protease plasmepsin II. Bioorg Med Chem Lett. 2007 Jun 1;17(11):3048-52. DMYGNZA RU https://pubmed.ncbi.nlm.nih.gov/17400453 DM1OPYT DI DM1OPYT DM1OPYT DN KNI-10315 DM1OPYT MI TTXMNHO DM1OPYT MN Plasmodium Plasmepsin 2 (Malaria PLA2) DM1OPYT MT DTT DM1OPYT MA Inhibitor DM1OPYT RN Additional interaction of allophenylnorstatine-containing tripeptidomimetics with malarial aspartic protease plasmepsin II. Bioorg Med Chem Lett. 2007 Jun 1;17(11):3048-52. DM1OPYT RU https://pubmed.ncbi.nlm.nih.gov/17400453 DMMIDCG DI DMMIDCG DMMIDCG DN KNI-10316 DMMIDCG MI TTXMNHO DMMIDCG MN Plasmodium Plasmepsin 2 (Malaria PLA2) DMMIDCG MT DTT DMMIDCG MA Inhibitor DMMIDCG RN Additional interaction of allophenylnorstatine-containing tripeptidomimetics with malarial aspartic protease plasmepsin II. Bioorg Med Chem Lett. 2007 Jun 1;17(11):3048-52. DMMIDCG RU https://pubmed.ncbi.nlm.nih.gov/17400453 DMKVPMS DI DMKVPMS DMKVPMS DN KNI-10332 DMKVPMS MI TTXMNHO DMKVPMS MN Plasmodium Plasmepsin 2 (Malaria PLA2) DMKVPMS MT DTT DMKVPMS MA Inhibitor DMKVPMS RN Additional interaction of allophenylnorstatine-containing tripeptidomimetics with malarial aspartic protease plasmepsin II. Bioorg Med Chem Lett. 2007 Jun 1;17(11):3048-52. DMKVPMS RU https://pubmed.ncbi.nlm.nih.gov/17400453 DMF9P25 DI DMF9P25 DMF9P25 DN KNI-10341 DMF9P25 MI TTXMNHO DMF9P25 MN Plasmodium Plasmepsin 2 (Malaria PLA2) DMF9P25 MT DTT DMF9P25 MA Inhibitor DMF9P25 RN Additional interaction of allophenylnorstatine-containing tripeptidomimetics with malarial aspartic protease plasmepsin II. Bioorg Med Chem Lett. 2007 Jun 1;17(11):3048-52. DMF9P25 RU https://pubmed.ncbi.nlm.nih.gov/17400453 DMDM5BL DI DMDM5BL DMDM5BL DN KNI-10342 DMDM5BL MI TTXMNHO DMDM5BL MN Plasmodium Plasmepsin 2 (Malaria PLA2) DMDM5BL MT DTT DMDM5BL MA Inhibitor DMDM5BL RN Additional interaction of allophenylnorstatine-containing tripeptidomimetics with malarial aspartic protease plasmepsin II. Bioorg Med Chem Lett. 2007 Jun 1;17(11):3048-52. DMDM5BL RU https://pubmed.ncbi.nlm.nih.gov/17400453 DM8SIRL DI DM8SIRL DM8SIRL DN KNI-10368 DM8SIRL MI TTXMNHO DM8SIRL MN Plasmodium Plasmepsin 2 (Malaria PLA2) DM8SIRL MT DTT DM8SIRL MA Inhibitor DM8SIRL RN Additional interaction of allophenylnorstatine-containing tripeptidomimetics with malarial aspartic protease plasmepsin II. Bioorg Med Chem Lett. 2007 Jun 1;17(11):3048-52. DM8SIRL RU https://pubmed.ncbi.nlm.nih.gov/17400453 DM97STY DI DM97STY DM97STY DN KNI-10369 DM97STY MI TTXMNHO DM97STY MN Plasmodium Plasmepsin 2 (Malaria PLA2) DM97STY MT DTT DM97STY MA Inhibitor DM97STY RN Antimalarial activity enhancement in hydroxymethylcarbonyl (HMC) isostere-based dipeptidomimetics targeting malarial aspartic protease plasmepsin. Bioorg Med Chem. 2008 Dec 1;16(23):10049-60. DM97STY RU https://pubmed.ncbi.nlm.nih.gov/18952439 DM4AUCE DI DM4AUCE DM4AUCE DN KNI-10372 DM4AUCE MI TTXMNHO DM4AUCE MN Plasmodium Plasmepsin 2 (Malaria PLA2) DM4AUCE MT DTT DM4AUCE MA Inhibitor DM4AUCE RN Additional interaction of allophenylnorstatine-containing tripeptidomimetics with malarial aspartic protease plasmepsin II. Bioorg Med Chem Lett. 2007 Jun 1;17(11):3048-52. DM4AUCE RU https://pubmed.ncbi.nlm.nih.gov/17400453 DMEN2L3 DI DMEN2L3 DMEN2L3 DN KNI-10526 DMEN2L3 MI TTXMNHO DMEN2L3 MN Plasmodium Plasmepsin 2 (Malaria PLA2) DMEN2L3 MT DTT DMEN2L3 MA Inhibitor DMEN2L3 RN Antimalarial activity enhancement in hydroxymethylcarbonyl (HMC) isostere-based dipeptidomimetics targeting malarial aspartic protease plasmepsin. Bioorg Med Chem. 2008 Dec 1;16(23):10049-60. DMEN2L3 RU https://pubmed.ncbi.nlm.nih.gov/18952439 DMU4K7O DI DMU4K7O DMU4K7O DN KNI-10527 DMU4K7O MI TTXMNHO DMU4K7O MN Plasmodium Plasmepsin 2 (Malaria PLA2) DMU4K7O MT DTT DMU4K7O MA Inhibitor DMU4K7O RN Antimalarial activity enhancement in hydroxymethylcarbonyl (HMC) isostere-based dipeptidomimetics targeting malarial aspartic protease plasmepsin. Bioorg Med Chem. 2008 Dec 1;16(23):10049-60. DMU4K7O RU https://pubmed.ncbi.nlm.nih.gov/18952439 DMDRWYG DI DMDRWYG DMDRWYG DN KNI-10529 DMDRWYG MI TTXMNHO DMDRWYG MN Plasmodium Plasmepsin 2 (Malaria PLA2) DMDRWYG MT DTT DMDRWYG MA Inhibitor DMDRWYG RN Antimalarial activity enhancement in hydroxymethylcarbonyl (HMC) isostere-based dipeptidomimetics targeting malarial aspartic protease plasmepsin. Bioorg Med Chem. 2008 Dec 1;16(23):10049-60. DMDRWYG RU https://pubmed.ncbi.nlm.nih.gov/18952439 DM7XEIY DI DM7XEIY DM7XEIY DN KNI-10538 DM7XEIY MI TTXMNHO DM7XEIY MN Plasmodium Plasmepsin 2 (Malaria PLA2) DM7XEIY MT DTT DM7XEIY MA Inhibitor DM7XEIY RN Improvement of both plasmepsin inhibitory activity and antimalarial activity by 2-aminoethylamino substitution. Bioorg Med Chem Lett. 2010 Aug 15;20(16):4836-9. DM7XEIY RU https://pubmed.ncbi.nlm.nih.gov/20634066 DMLWOFY DI DMLWOFY DMLWOFY DN KNI-10539 DMLWOFY MI TTXMNHO DMLWOFY MN Plasmodium Plasmepsin 2 (Malaria PLA2) DMLWOFY MT DTT DMLWOFY MA Inhibitor DMLWOFY RN Antimalarial activity enhancement in hydroxymethylcarbonyl (HMC) isostere-based dipeptidomimetics targeting malarial aspartic protease plasmepsin. Bioorg Med Chem. 2008 Dec 1;16(23):10049-60. DMLWOFY RU https://pubmed.ncbi.nlm.nih.gov/18952439 DMP87U4 DI DMP87U4 DMP87U4 DN KNI-10541 DMP87U4 MI TTXMNHO DMP87U4 MN Plasmodium Plasmepsin 2 (Malaria PLA2) DMP87U4 MT DTT DMP87U4 MA Inhibitor DMP87U4 RN Antimalarial activity enhancement in hydroxymethylcarbonyl (HMC) isostere-based dipeptidomimetics targeting malarial aspartic protease plasmepsin. Bioorg Med Chem. 2008 Dec 1;16(23):10049-60. DMP87U4 RU https://pubmed.ncbi.nlm.nih.gov/18952439 DMGUABP DI DMGUABP DMGUABP DN KNI-10737 DMGUABP MI TTXMNHO DMGUABP MN Plasmodium Plasmepsin 2 (Malaria PLA2) DMGUABP MT DTT DMGUABP MA Inhibitor DMGUABP RN Improvement of both plasmepsin inhibitory activity and antimalarial activity by 2-aminoethylamino substitution. Bioorg Med Chem Lett. 2010 Aug 15;20(16):4836-9. DMGUABP RU https://pubmed.ncbi.nlm.nih.gov/20634066 DMPWY6H DI DMPWY6H DMPWY6H DN KNI-10740 DMPWY6H MI TTXMNHO DMPWY6H MN Plasmodium Plasmepsin 2 (Malaria PLA2) DMPWY6H MT DTT DMPWY6H MA Inhibitor DMPWY6H RN Improvement of both plasmepsin inhibitory activity and antimalarial activity by 2-aminoethylamino substitution. Bioorg Med Chem Lett. 2010 Aug 15;20(16):4836-9. DMPWY6H RU https://pubmed.ncbi.nlm.nih.gov/20634066 DM7TW4C DI DM7TW4C DM7TW4C DN KNI-10741 DM7TW4C MI TTXMNHO DM7TW4C MN Plasmodium Plasmepsin 2 (Malaria PLA2) DM7TW4C MT DTT DM7TW4C MA Inhibitor DM7TW4C RN Improvement of both plasmepsin inhibitory activity and antimalarial activity by 2-aminoethylamino substitution. Bioorg Med Chem Lett. 2010 Aug 15;20(16):4836-9. DM7TW4C RU https://pubmed.ncbi.nlm.nih.gov/20634066 DM4D9T3 DI DM4D9T3 DM4D9T3 DN KNI-10742 DM4D9T3 MI TTXMNHO DM4D9T3 MN Plasmodium Plasmepsin 2 (Malaria PLA2) DM4D9T3 MT DTT DM4D9T3 MA Inhibitor DM4D9T3 RN Improvement of both plasmepsin inhibitory activity and antimalarial activity by 2-aminoethylamino substitution. Bioorg Med Chem Lett. 2010 Aug 15;20(16):4836-9. DM4D9T3 RU https://pubmed.ncbi.nlm.nih.gov/20634066 DM0VSPE DI DM0VSPE DM0VSPE DN KNI-10743 DM0VSPE MI TTXMNHO DM0VSPE MN Plasmodium Plasmepsin 2 (Malaria PLA2) DM0VSPE MT DTT DM0VSPE MA Inhibitor DM0VSPE RN Improvement of both plasmepsin inhibitory activity and antimalarial activity by 2-aminoethylamino substitution. Bioorg Med Chem Lett. 2010 Aug 15;20(16):4836-9. DM0VSPE RU https://pubmed.ncbi.nlm.nih.gov/20634066 DMM2A5Q DI DMM2A5Q DMM2A5Q DN KNI-10758 DMM2A5Q MI TTXMNHO DMM2A5Q MN Plasmodium Plasmepsin 2 (Malaria PLA2) DMM2A5Q MT DTT DMM2A5Q MA Inhibitor DMM2A5Q RN Improvement of both plasmepsin inhibitory activity and antimalarial activity by 2-aminoethylamino substitution. Bioorg Med Chem Lett. 2010 Aug 15;20(16):4836-9. DMM2A5Q RU https://pubmed.ncbi.nlm.nih.gov/20634066 DMAF1W3 DI DMAF1W3 DMAF1W3 DN KNI-10759 DMAF1W3 MI TTXMNHO DMAF1W3 MN Plasmodium Plasmepsin 2 (Malaria PLA2) DMAF1W3 MT DTT DMAF1W3 MA Inhibitor DMAF1W3 RN Improvement of both plasmepsin inhibitory activity and antimalarial activity by 2-aminoethylamino substitution. Bioorg Med Chem Lett. 2010 Aug 15;20(16):4836-9. DMAF1W3 RU https://pubmed.ncbi.nlm.nih.gov/20634066 DMT5FIP DI DMT5FIP DMT5FIP DN KNI-10760 DMT5FIP MI TTXMNHO DMT5FIP MN Plasmodium Plasmepsin 2 (Malaria PLA2) DMT5FIP MT DTT DMT5FIP MA Inhibitor DMT5FIP RN Improvement of both plasmepsin inhibitory activity and antimalarial activity by 2-aminoethylamino substitution. Bioorg Med Chem Lett. 2010 Aug 15;20(16):4836-9. DMT5FIP RU https://pubmed.ncbi.nlm.nih.gov/20634066 DMXUTWZ DI DMXUTWZ DMXUTWZ DN KNI-10761 DMXUTWZ MI TTXMNHO DMXUTWZ MN Plasmodium Plasmepsin 2 (Malaria PLA2) DMXUTWZ MT DTT DMXUTWZ MA Inhibitor DMXUTWZ RN Improvement of both plasmepsin inhibitory activity and antimalarial activity by 2-aminoethylamino substitution. Bioorg Med Chem Lett. 2010 Aug 15;20(16):4836-9. DMXUTWZ RU https://pubmed.ncbi.nlm.nih.gov/20634066 DM73WB2 DI DM73WB2 DM73WB2 DN KNI-10762 DM73WB2 MI TTXMNHO DM73WB2 MN Plasmodium Plasmepsin 2 (Malaria PLA2) DM73WB2 MT DTT DM73WB2 MA Inhibitor DM73WB2 RN Improvement of both plasmepsin inhibitory activity and antimalarial activity by 2-aminoethylamino substitution. Bioorg Med Chem Lett. 2010 Aug 15;20(16):4836-9. DM73WB2 RU https://pubmed.ncbi.nlm.nih.gov/20634066 DMKAY5G DI DMKAY5G DMKAY5G DN KNI-10763 DMKAY5G MI TTXMNHO DMKAY5G MN Plasmodium Plasmepsin 2 (Malaria PLA2) DMKAY5G MT DTT DMKAY5G MA Inhibitor DMKAY5G RN Improvement of both plasmepsin inhibitory activity and antimalarial activity by 2-aminoethylamino substitution. Bioorg Med Chem Lett. 2010 Aug 15;20(16):4836-9. DMKAY5G RU https://pubmed.ncbi.nlm.nih.gov/20634066 DMZX430 DI DMZX430 DMZX430 DN KNI-1293 DMZX430 MI TTXMNHO DMZX430 MN Plasmodium Plasmepsin 2 (Malaria PLA2) DMZX430 MT DTT DMZX430 MA Inhibitor DMZX430 RN Antimalarial activity enhancement in hydroxymethylcarbonyl (HMC) isostere-based dipeptidomimetics targeting malarial aspartic protease plasmepsin. Bioorg Med Chem. 2008 Dec 1;16(23):10049-60. DMZX430 RU https://pubmed.ncbi.nlm.nih.gov/18952439 DMS61DB DI DMS61DB DMS61DB DN KNI-227 DMS61DB MI TTXMNHO DMS61DB MN Plasmodium Plasmepsin 2 (Malaria PLA2) DMS61DB MT DTT DMS61DB MA Inhibitor DMS61DB RN Additional interaction of allophenylnorstatine-containing tripeptidomimetics with malarial aspartic protease plasmepsin II. Bioorg Med Chem Lett. 2007 Jun 1;17(11):3048-52. DMS61DB RU https://pubmed.ncbi.nlm.nih.gov/17400453 DM105NU DI DM105NU DM105NU DN KNI-727 DM105NU MI TTXMNHO DM105NU MN Plasmodium Plasmepsin 2 (Malaria PLA2) DM105NU MT DTT DM105NU MA Inhibitor DM105NU RN Identification and characterization of allophenylnorstatine-based inhibitors of plasmepsin II, an antimalarial target. Biochemistry. 2002 Feb 19;41(7):2273-80. DM105NU RU https://pubmed.ncbi.nlm.nih.gov/11841219 DMZF3E9 DI DMZF3E9 DMZF3E9 DN KNT-5 DMZF3E9 MI TTKWM86 DMZF3E9 MN Opioid receptor mu (MOP) DMZF3E9 MT DTT DMZF3E9 MA Inhibitor DMZF3E9 RN Investigation of Beckett-Casy model 1: synthesis of novel 16,17-seco-naltrexone derivatives and their pharmacology. Bioorg Med Chem Lett. 2010 Feb 1;20(3):1055-8. DMZF3E9 RU https://pubmed.ncbi.nlm.nih.gov/20056539 DM9M5HC DI DM9M5HC DM9M5HC DN KNT-62 DM9M5HC MI TTQW87Y DM9M5HC MN Opioid receptor kappa (OPRK1) DM9M5HC MT DTT DM9M5HC MA Inhibitor DM9M5HC RN Drug design and synthesis of a novel kappa opioid receptor agonist with an oxabicyclo[2.2.2]octane skeleton and its pharmacology. Bioorg Med Chem Lett. 2010 Jan 1;20(1):121-4. DM9M5HC RU https://pubmed.ncbi.nlm.nih.gov/19962305 DM9M5HC DI DM9M5HC DM9M5HC DN KNT-62 DM9M5HC MI TTKWM86 DM9M5HC MN Opioid receptor mu (MOP) DM9M5HC MT DTT DM9M5HC MA Inhibitor DM9M5HC RN Drug design and synthesis of a novel kappa opioid receptor agonist with an oxabicyclo[2.2.2]octane skeleton and its pharmacology. Bioorg Med Chem Lett. 2010 Jan 1;20(1):121-4. DM9M5HC RU https://pubmed.ncbi.nlm.nih.gov/19962305 DM0U5N9 DI DM0U5N9 DM0U5N9 DN KNT-63 DM0U5N9 MI TTQW87Y DM0U5N9 MN Opioid receptor kappa (OPRK1) DM0U5N9 MT DTT DM0U5N9 MA Inhibitor DM0U5N9 RN Drug design and synthesis of a novel kappa opioid receptor agonist with an oxabicyclo[2.2.2]octane skeleton and its pharmacology. Bioorg Med Chem Lett. 2010 Jan 1;20(1):121-4. DM0U5N9 RU https://pubmed.ncbi.nlm.nih.gov/19962305 DM0U5N9 DI DM0U5N9 DM0U5N9 DN KNT-63 DM0U5N9 MI TTKWM86 DM0U5N9 MN Opioid receptor mu (MOP) DM0U5N9 MT DTT DM0U5N9 MA Inhibitor DM0U5N9 RN Drug design and synthesis of a novel kappa opioid receptor agonist with an oxabicyclo[2.2.2]octane skeleton and its pharmacology. Bioorg Med Chem Lett. 2010 Jan 1;20(1):121-4. DM0U5N9 RU https://pubmed.ncbi.nlm.nih.gov/19962305 DMNWXCA DI DMNWXCA DMNWXCA DN KNX-Monoclonal204 DMNWXCA MI TTE4KHA DMNWXCA MN Amyloid beta A4 protein (APP) DMNWXCA MT DTT DMNWXCA RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2402). DMNWXCA RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2402 DMVGNZJ DI DMVGNZJ DMVGNZJ DN KO-286011 DMVGNZJ MI TTQL5VC DMVGNZJ MN Platelet-activating factor receptor (PTAFR) DMVGNZJ MT DTT DMVGNZJ MA Modulator DMVGNZJ RN Platelet-activating factor (PAF) inhibitory profile of KO-286011 on blood platelets in vitro and in vivo. Naunyn Schmiedebergs Arch Pharmacol. 1990 Dec;342(6):713-8. DMVGNZJ RU https://www.ncbi.nlm.nih.gov/pubmed/2096302 DMAJKRX DI DMAJKRX DMAJKRX DN Kodaistatin A DMAJKRX MI TT1KPBZ DMAJKRX MN Glucose-6-phosphate translocase (SLC37A4) DMAJKRX MT DTT DMAJKRX MA Inhibitor DMAJKRX RN Kodaistatins, novel inhibitors of glucose-6-phosphate translocase T1 from Aspergillus terreus thom DSM 11247. Isolation and structural elucidation. J Antibiot (Tokyo). 2000 Jul;53(7):677-86. DMAJKRX RU https://pubmed.ncbi.nlm.nih.gov/10994809 DM72WQ3 DI DM72WQ3 DM72WQ3 DN Kodaistatin C DM72WQ3 MI TT1KPBZ DM72WQ3 MN Glucose-6-phosphate translocase (SLC37A4) DM72WQ3 MT DTT DM72WQ3 MA Inhibitor DM72WQ3 RN Kodaistatins, novel inhibitors of glucose-6-phosphate translocase T1 from Aspergillus terreus thom DSM 11247. Isolation and structural elucidation. J Antibiot (Tokyo). 2000 Jul;53(7):677-86. DM72WQ3 RU https://pubmed.ncbi.nlm.nih.gov/10994809 DMP84CS DI DMP84CS DMP84CS DN KOJIC ACID DMP84CS MI TTULVH8 DMP84CS MN Tyrosinase (TYR) DMP84CS MT DTT DMP84CS MA Inhibitor DMP84CS RN A novel ring-expanded product with enhanced tyrosinase inhibitory activity from classical Fe-catalyzed oxidation of rosmarinic acid, a potent antio... Bioorg Med Chem Lett. 2010 Dec 15;20(24):7393-6. DMP84CS RU https://pubmed.ncbi.nlm.nih.gov/21041086 DMRB1AT DI DMRB1AT DMRB1AT DN Kojic acid-phenylalanine amide DMRB1AT MI TTULVH8 DMRB1AT MN Tyrosinase (TYR) DMRB1AT MT DTT DMRB1AT MA Inhibitor DMRB1AT RN Kojic acid-amino acid conjugates as tyrosinase inhibitors. Bioorg Med Chem Lett. 2009 Oct 1;19(19):5586-9. DMRB1AT RU https://pubmed.ncbi.nlm.nih.gov/19700313 DMYDGA7 DI DMYDGA7 DMYDGA7 DN KOS1326 DMYDGA7 MI TT953CX DMYDGA7 MN Motilin receptor (MLNR) DMYDGA7 MT DTT DMYDGA7 MA Agonist DMYDGA7 RN Desensitization of the human motilin receptor by motilides. J Pharmacol Exp Ther. 2005 Jun;313(3):1397-405. DMYDGA7 RU https://pubmed.ncbi.nlm.nih.gov/15764739 DM1SKNP DI DM1SKNP DM1SKNP DN KOSN1559 DM1SKNP MI TT78R5H DM1SKNP MN Heat shock protein 90 alpha (HSP90A) DM1SKNP MT DTT DM1SKNP MA Inhibitor DM1SKNP RN Recent advances in Hsp90 inhibitors as antitumor agents. Anticancer Agents Med Chem. 2008 Oct;8(7):761-82. DM1SKNP RU https://pubmed.ncbi.nlm.nih.gov/18855578 DMT1H9Z DI DMT1H9Z DMT1H9Z DN KOTALANOL DMT1H9Z MI TTXWASR DMT1H9Z MN Intestinal maltase-glucoamylase (MGAM) DMT1H9Z MT DTT DMT1H9Z MA Inhibitor DMT1H9Z RN Probing the active-site requirements of human intestinal N-terminal maltase-glucoamylase: Synthesis and enzyme inhibitory activities of a six-membe... Bioorg Med Chem. 2010 Nov 15;18(22):7794-8. DMT1H9Z RU https://pubmed.ncbi.nlm.nih.gov/20970346 DMUZSJ2 DI DMUZSJ2 DMUZSJ2 DN KP772 DMUZSJ2 MI TT0JLSD DMUZSJ2 MN Multidrug resistance protein (MDR) DMUZSJ2 MT DTT DMUZSJ2 MA Inhibitor DMUZSJ2 RN Thiazolides: a new class of antiviral drugs. Expert Opin Drug Metab Toxicol. 2009 Jun;5(6):667-74. DMUZSJ2 RU https://pubmed.ncbi.nlm.nih.gov/19442032 DMC4YGT DI DMC4YGT DMC4YGT DN KR-33889 DMC4YGT MI TTVDSZ0 DMC4YGT MN Poly [ADP-ribose] polymerase 1 (PARP1) DMC4YGT MT DTT DMC4YGT MA Inhibitor DMC4YGT RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2771). DMC4YGT RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2771 DMIEKJ4 DI DMIEKJ4 DMIEKJ4 DN KR61639 DMIEKJ4 MI TTELIN2 DMIEKJ4 MN PTPN1 messenger RNA (PTPN1 mRNA) DMIEKJ4 MT DTT DMIEKJ4 MA Inhibitor DMIEKJ4 RN Discovery of a novel protein tyrosine phosphatase-1B inhibitor, KR61639: potential development as an antihyperglycemic agent. Eur J Pharmacol. 2004 Feb 6;485(1-3):333-9. DMIEKJ4 RU https://pubmed.ncbi.nlm.nih.gov/14757158 DM7G8KR DI DM7G8KR DM7G8KR DN KR-62436 DM7G8KR MI TTDIGC1 DM7G8KR MN Dipeptidyl peptidase 4 (DPP-4) DM7G8KR MT DTT DM7G8KR MA Inhibitor DM7G8KR RN Medicinal chemistry approaches to the inhibition of dipeptidyl peptidase-4 for the treatment of type 2 diabetes. Bioorg Med Chem. 2009 Mar 1;17(5):1783-802. DM7G8KR RU https://pubmed.ncbi.nlm.nih.gov/19217790 DMXFBER DI DMXFBER DMXFBER DN KRH-102053 DMXFBER MI TT9ISBX DMXFBER MN HIF-prolyl hydroxylase 2 (HPH-2) DMXFBER MT DTT DMXFBER MA Activator DMXFBER RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2833). DMXFBER RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2833 DMLIK7X DI DMLIK7X DMLIK7X DN KRP 203-phosphate DMLIK7X MI TT9JZCK DMLIK7X MN Sphingosine-1-phosphate receptor 1 (S1PR1) DMLIK7X MT DTT DMLIK7X MA Agonist DMLIK7X RN A novel sphingosine 1-phosphate receptor agonist, 2-amino-2-propanediol hydrochloride (KRP-203), regulates chronic colitis in interleukin-10 gene-d... J Pharmacol Exp Ther. 2008 Jan;324(1):276-83. DMLIK7X RU https://pubmed.ncbi.nlm.nih.gov/17898319 DMLIK7X DI DMLIK7X DMLIK7X DN KRP 203-phosphate DMLIK7X MI TTZ8C5Q DMLIK7X MN Sphingosine-1-phosphate receptor 4 (S1PR4) DMLIK7X MT DTT DMLIK7X MA Agonist DMLIK7X RN A novel sphingosine 1-phosphate receptor agonist, 2-amino-2-propanediol hydrochloride (KRP-203), regulates chronic colitis in interleukin-10 gene-d... J Pharmacol Exp Ther. 2008 Jan;324(1):276-83. DMLIK7X RU https://pubmed.ncbi.nlm.nih.gov/17898319 DMJX9E1 DI DMJX9E1 DMJX9E1 DN KRP-100 DMJX9E1 MI TTKWM86 DMJX9E1 MN Opioid receptor mu (MOP) DMJX9E1 MT DTT DMJX9E1 MA Antagonist DMJX9E1 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 319). DMJX9E1 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=319 DM5KFBP DI DM5KFBP DM5KFBP DN KRP-107 DM5KFBP MI TT9JZCK DM5KFBP MN Sphingosine-1-phosphate receptor 1 (S1PR1) DM5KFBP MT DTT DM5KFBP MA Modulator DM5KFBP RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 275). DM5KFBP RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=275 DME9HZC DI DME9HZC DME9HZC DN KRP-110 DME9HZC MI TTKWM86 DME9HZC MN Opioid receptor mu (MOP) DME9HZC MT DTT DME9HZC MA Modulator DME9HZC RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 319). DME9HZC RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=319 DMC92ER DI DMC92ER DMC92ER DN KSG-504 DMC92ER MI TTCG0AL DMC92ER MN Cholecystokinin receptor type A (CCKAR) DMC92ER MT DTT DMC92ER MA Antagonist DMC92ER RN Effects of KSG-504, a new CCK-A receptor antagonist, on gallbladder and gastrointestinal functions. Nihon Yakurigaku Zasshi. 1996 Jan;107(1):33-44. DMC92ER RU https://pubmed.ncbi.nlm.nih.gov/8720296 DM5DTMQ DI DM5DTMQ DM5DTMQ DN KSG-LDTKNYKQTSV DM5DTMQ MI TT9PB26 DM5DTMQ MN Presynaptic density protein 95 (DLG4) DM5DTMQ MT DTT DM5DTMQ MA Inhibitor DM5DTMQ RN Modified peptides as potent inhibitors of the postsynaptic density-95/N-methyl-D-aspartate receptor interaction. J Med Chem. 2008 Oct 23;51(20):6450-9. DM5DTMQ RU https://pubmed.ncbi.nlm.nih.gov/18811137 DMPLFRC DI DMPLFRC DMPLFRC DN KSG-YEKLSSIESDV DMPLFRC MI TT9PB26 DMPLFRC MN Presynaptic density protein 95 (DLG4) DMPLFRC MT DTT DMPLFRC MA Inhibitor DMPLFRC RN Modified peptides as potent inhibitors of the postsynaptic density-95/N-methyl-D-aspartate receptor interaction. J Med Chem. 2008 Oct 23;51(20):6450-9. DMPLFRC RU https://pubmed.ncbi.nlm.nih.gov/18811137 DMXBITO DI DMXBITO DMXBITO DN KSP-BCS-1-alpha-CHF2-1624F2-2 DMXBITO MI TTK59TV DMXBITO MN Vitamin D3 receptor (VDR) DMXBITO MT DTT DMXBITO MA Inhibitor DMXBITO RN Low-calcemic, highly antiproliferative, 1-difluoromethyl hybrid analogs of the natural hormone 1alpha,25-dihydroxyvitamin D3: design, synthesis, an... J Med Chem. 2006 Dec 14;49(25):7513-7. DMXBITO RU https://pubmed.ncbi.nlm.nih.gov/17149880 DMJV3R7 DI DMJV3R7 DMJV3R7 DN KSP-BCS-1-alpha-CHF2-20-epi-22-oxabishomo-26-OH DMJV3R7 MI TTK59TV DMJV3R7 MN Vitamin D3 receptor (VDR) DMJV3R7 MT DTT DMJV3R7 MA Inhibitor DMJV3R7 RN Low-calcemic, highly antiproliferative, 1-difluoromethyl hybrid analogs of the natural hormone 1alpha,25-dihydroxyvitamin D3: design, synthesis, an... J Med Chem. 2006 Dec 14;49(25):7513-7. DMJV3R7 RU https://pubmed.ncbi.nlm.nih.gov/17149880 DMT0CR5 DI DMT0CR5 DMT0CR5 DN KST-5468 DMT0CR5 MI TTZPWGN DMT0CR5 MN Voltage-gated calcium channel alpha Cav3.2 (CACNA1H) DMT0CR5 MT DTT DMT0CR5 MA Antagonist DMT0CR5 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 536). DMT0CR5 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=536 DMOBYU3 DI DMOBYU3 DMOBYU3 DN KT 5823 DMOBYU3 MI TTOXS3C DMOBYU3 MN Muscarinic acetylcholine receptor (CHRM) DMOBYU3 MT DTT DMOBYU3 MA Modulator (allosteric modulator) DMOBYU3 RN Allosteric interactions of staurosporine and other indolocarbazoles with N-[methyl-(3)H]scopolamine and acetylcholine at muscarinic receptor subtypes: identification of a second allosteric site. Mol Pharmacol. 2000 Jul;58(1):194-207. DMOBYU3 RU https://pubmed.ncbi.nlm.nih.gov/10860942 DM9J50F DI DM9J50F DM9J50F DN KT-5720 DM9J50F MI TT4TQBX DM9J50F MN Extracellular signal-regulated kinase 2 (ERK2) DM9J50F MT DTT DM9J50F MA Inhibitor DM9J50F RN Specificity and mechanism of action of some commonly used protein kinase inhibitors. Biochem J. 2000 Oct 1;351(Pt 1):95-105. DM9J50F RU https://pubmed.ncbi.nlm.nih.gov/10998351 DM9J50F DI DM9J50F DM9J50F DN KT-5720 DM9J50F MI TTYT93M DM9J50F MN MAP kinase p38 (MAPK12) DM9J50F MT DTT DM9J50F MA Inhibitor DM9J50F RN Specificity and mechanism of action of some commonly used protein kinase inhibitors. Biochem J. 2000 Oct 1;351(Pt 1):95-105. DM9J50F RU https://pubmed.ncbi.nlm.nih.gov/10998351 DM9J50F DI DM9J50F DM9J50F DN KT-5720 DM9J50F MI TTFJ8Q1 DM9J50F MN Protein kinase C alpha (PRKCA) DM9J50F MT DTT DM9J50F MA Inhibitor DM9J50F RN Specificity and mechanism of action of some commonly used protein kinase inhibitors. Biochem J. 2000 Oct 1;351(Pt 1):95-105. DM9J50F RU https://pubmed.ncbi.nlm.nih.gov/10998351 DM9J50F DI DM9J50F DM9J50F DN KT-5720 DM9J50F MI TTZN7RP DM9J50F MN Rho-associated protein kinase 1 (ROCK1) DM9J50F MT DTT DM9J50F MA Inhibitor DM9J50F RN Specificity and mechanism of action of some commonly used protein kinase inhibitors. Biochem J. 2000 Oct 1;351(Pt 1):95-105. DM9J50F RU https://pubmed.ncbi.nlm.nih.gov/10998351 DM9J50F DI DM9J50F DM9J50F DN KT-5720 DM9J50F MI TTG0U4H DM9J50F MN Ribosomal protein S6 kinase beta-1 (S6K1) DM9J50F MT DTT DM9J50F MA Inhibitor DM9J50F RN Specificity and mechanism of action of some commonly used protein kinase inhibitors. Biochem J. 2000 Oct 1;351(Pt 1):95-105. DM9J50F RU https://pubmed.ncbi.nlm.nih.gov/10998351 DM9J50F DI DM9J50F DM9J50F DN KT-5720 DM9J50F MI TTQBR95 DM9J50F MN Stress-activated protein kinase 2a (p38 alpha) DM9J50F MT DTT DM9J50F MA Inhibitor DM9J50F RN Specificity and mechanism of action of some commonly used protein kinase inhibitors. Biochem J. 2000 Oct 1;351(Pt 1):95-105. DM9J50F RU https://pubmed.ncbi.nlm.nih.gov/10998351 DM9J50F DI DM9J50F DM9J50F DN KT-5720 DM9J50F MI TT73U6C DM9J50F MN Stress-activated protein kinase 2b (p38 beta) DM9J50F MT DTT DM9J50F MA Inhibitor DM9J50F RN Specificity and mechanism of action of some commonly used protein kinase inhibitors. Biochem J. 2000 Oct 1;351(Pt 1):95-105. DM9J50F RU https://pubmed.ncbi.nlm.nih.gov/10998351 DM9J50F DI DM9J50F DM9J50F DN KT-5720 DM9J50F MI TT0K6EO DM9J50F MN Stress-activated protein kinase JNK1 (JNK1) DM9J50F MT DTT DM9J50F MA Inhibitor DM9J50F RN Specificity and mechanism of action of some commonly used protein kinase inhibitors. Biochem J. 2000 Oct 1;351(Pt 1):95-105. DM9J50F RU https://pubmed.ncbi.nlm.nih.gov/10998351 DMXIUO5 DI DMXIUO5 DMXIUO5 DN KT6006 DMXIUO5 MI TTGTQHC DMXIUO5 MN DNA topoisomerase I (TOP1) DMXIUO5 MT DTT DMXIUO5 MA Inducer DMXIUO5 RN Induction of mammalian DNA topoisomerase I mediated DNA cleavage by antitumor indolocarbazole derivatives. Biochemistry. 1992 Dec 8;31(48):12069-75. DMXIUO5 RU https://pubmed.ncbi.nlm.nih.gov/1333791 DMRDZ7I DI DMRDZ7I DMRDZ7I DN KT6528 DMRDZ7I MI TTGTQHC DMRDZ7I MN DNA topoisomerase I (TOP1) DMRDZ7I MT DTT DMRDZ7I MA Inducer DMRDZ7I RN Induction of mammalian DNA topoisomerase I mediated DNA cleavage by antitumor indolocarbazole derivatives. Biochemistry. 1992 Dec 8;31(48):12069-75. DMRDZ7I RU https://pubmed.ncbi.nlm.nih.gov/1333791 DMQWS6U DI DMQWS6U DMQWS6U DN KU-0060648 DMQWS6U MI TTK3PY9 DMQWS6U MN DNA-dependent protein kinase catalytic (PRKDC) DMQWS6U MT DTT DMQWS6U MA Inhibitor DMQWS6U RN 1-substituted (Dibenzo[b,d]thiophen-4-yl)-2-morpholino-4H-chromen-4-ones endowed with dual DNA-PK/PI3-K inhibitory activity. J Med Chem. 2013 Aug 22;56(16):6386-401. DMQWS6U RU https://pubmed.ncbi.nlm.nih.gov/23855836 DMQWS6U DI DMQWS6U DMQWS6U DN KU-0060648 DMQWS6U MI TTTHBCA DMQWS6U MN PI3-kinase beta (PIK3CB) DMQWS6U MT DTT DMQWS6U MA Inhibitor DMQWS6U RN 1-substituted (Dibenzo[b,d]thiophen-4-yl)-2-morpholino-4H-chromen-4-ones endowed with dual DNA-PK/PI3-K inhibitory activity. J Med Chem. 2013 Aug 22;56(16):6386-401. DMQWS6U RU https://pubmed.ncbi.nlm.nih.gov/23855836 DMQWS6U DI DMQWS6U DMQWS6U DN KU-0060648 DMQWS6U MI TTHBTOP DMQWS6U MN PI3-kinase gamma (PIK3CG) DMQWS6U MT DTT DMQWS6U MA Inhibitor DMQWS6U RN 1-substituted (Dibenzo[b,d]thiophen-4-yl)-2-morpholino-4H-chromen-4-ones endowed with dual DNA-PK/PI3-K inhibitory activity. J Med Chem. 2013 Aug 22;56(16):6386-401. DMQWS6U RU https://pubmed.ncbi.nlm.nih.gov/23855836 DMDT42X DI DMDT42X DMDT42X DN KU-55933 DMDT42X MI TTK3PY9 DMDT42X MN DNA-dependent protein kinase catalytic (PRKDC) DMDT42X MT DTT DMDT42X MA Inhibitor DMDT42X RN Pyranone, thiopyranone, and pyridone inhibitors of phosphatidylinositol 3-kinase related kinases. Structure-activity relationships for DNA-dependen... J Med Chem. 2007 Apr 19;50(8):1958-72. DMDT42X RU https://pubmed.ncbi.nlm.nih.gov/17371003 DMVGY6K DI DMVGY6K DMVGY6K DN KU-58684 DMVGY6K MI TTVDSZ0 DMVGY6K MN Poly [ADP-ribose] polymerase 1 (PARP1) DMVGY6K MT DTT DMVGY6K MA Inhibitor DMVGY6K RN Design, synthesis, and cytoprotective effect of 2-aminothiazole analogues as potent poly(ADP-ribose) polymerase-1 inhibitors. J Med Chem. 2009 Feb 12;52(3):718-25. DMVGY6K RU https://pubmed.ncbi.nlm.nih.gov/19125579 DMAVM94 DI DMAVM94 DMAVM94 DN Kuanoniamine D DMAVM94 MI TTK25J1 DMAVM94 MN Adenosine A1 receptor (ADORA1) DMAVM94 MT DTT DMAVM94 MA Inhibitor DMAVM94 RN Bioactive pyridoacridine alkaloids from the micronesian sponge Oceanapia sp. J Nat Prod. 1998 Feb;61(2):301-5. DMAVM94 RU https://pubmed.ncbi.nlm.nih.gov/9514015 DMAVM94 DI DMAVM94 DMAVM94 DN Kuanoniamine D DMAVM94 MI TTM2AOE DMAVM94 MN Adenosine A2a receptor (ADORA2A) DMAVM94 MT DTT DMAVM94 MA Inhibitor DMAVM94 RN Bioactive pyridoacridine alkaloids from the micronesian sponge Oceanapia sp. J Nat Prod. 1998 Feb;61(2):301-5. DMAVM94 RU https://pubmed.ncbi.nlm.nih.gov/9514015 DMLDUJ1 DI DMLDUJ1 DMLDUJ1 DN Kuraidin DMLDUJ1 MI TT06AWU DMLDUJ1 MN Phosphodiesterase 3A (PDE3A) DMLDUJ1 MT DTT DMLDUJ1 MA Inhibitor DMLDUJ1 RN A prenylated flavonol, sophoflavescenol: a potent and selective inhibitor of cGMP phosphodiesterase 5. Bioorg Med Chem Lett. 2002 Sep 2;12(17):2313-6. DMLDUJ1 RU https://pubmed.ncbi.nlm.nih.gov/12161123 DMLDUJ1 DI DMLDUJ1 DMLDUJ1 DN Kuraidin DMLDUJ1 MI TTZ97H5 DMLDUJ1 MN Phosphodiesterase 4A (PDE4A) DMLDUJ1 MT DTT DMLDUJ1 MA Inhibitor DMLDUJ1 RN A prenylated flavonol, sophoflavescenol: a potent and selective inhibitor of cGMP phosphodiesterase 5. Bioorg Med Chem Lett. 2002 Sep 2;12(17):2313-6. DMLDUJ1 RU https://pubmed.ncbi.nlm.nih.gov/12161123 DMLDUJ1 DI DMLDUJ1 DMLDUJ1 DN Kuraidin DMLDUJ1 MI TTVIAT9 DMLDUJ1 MN Phosphodiesterase 4B (PDE4B) DMLDUJ1 MT DTT DMLDUJ1 MA Inhibitor DMLDUJ1 RN A prenylated flavonol, sophoflavescenol: a potent and selective inhibitor of cGMP phosphodiesterase 5. Bioorg Med Chem Lett. 2002 Sep 2;12(17):2313-6. DMLDUJ1 RU https://pubmed.ncbi.nlm.nih.gov/12161123 DMLDUJ1 DI DMLDUJ1 DMLDUJ1 DN Kuraidin DMLDUJ1 MI TTJ0IQB DMLDUJ1 MN Phosphodiesterase 5A (PDE5A) DMLDUJ1 MT DTT DMLDUJ1 MA Inhibitor DMLDUJ1 RN A prenylated flavonol, sophoflavescenol: a potent and selective inhibitor of cGMP phosphodiesterase 5. Bioorg Med Chem Lett. 2002 Sep 2;12(17):2313-6. DMLDUJ1 RU https://pubmed.ncbi.nlm.nih.gov/12161123 DMLDUJ1 DI DMLDUJ1 DMLDUJ1 DN Kuraidin DMLDUJ1 MI TTF8JAT DMLDUJ1 MN SLC5A2 messenger RNA (SLC5A2 mRNA) DMLDUJ1 MT DTT DMLDUJ1 MA Inhibitor DMLDUJ1 RN Na+-glucose cotransporter (SGLT) inhibitory flavonoids from the roots of Sophora flavescens. Bioorg Med Chem. 2007 May 15;15(10):3445-9. DMLDUJ1 RU https://pubmed.ncbi.nlm.nih.gov/17374486 DMLDUJ1 DI DMLDUJ1 DMLDUJ1 DN Kuraidin DMLDUJ1 MI TT2UE56 DMLDUJ1 MN Sodium/glucose cotransporter 1 (SGLT1) DMLDUJ1 MT DTT DMLDUJ1 MA Inhibitor DMLDUJ1 RN Na+-glucose cotransporter (SGLT) inhibitory flavonoids from the roots of Sophora flavescens. Bioorg Med Chem. 2007 May 15;15(10):3445-9. DMLDUJ1 RU https://pubmed.ncbi.nlm.nih.gov/17374486 DMRV5YE DI DMRV5YE DMRV5YE DN KURARINOL DMRV5YE MI TT06AWU DMRV5YE MN Phosphodiesterase 3A (PDE3A) DMRV5YE MT DTT DMRV5YE MA Inhibitor DMRV5YE RN A prenylated flavonol, sophoflavescenol: a potent and selective inhibitor of cGMP phosphodiesterase 5. Bioorg Med Chem Lett. 2002 Sep 2;12(17):2313-6. DMRV5YE RU https://pubmed.ncbi.nlm.nih.gov/12161123 DMRV5YE DI DMRV5YE DMRV5YE DN KURARINOL DMRV5YE MI TTZ97H5 DMRV5YE MN Phosphodiesterase 4A (PDE4A) DMRV5YE MT DTT DMRV5YE MA Inhibitor DMRV5YE RN A prenylated flavonol, sophoflavescenol: a potent and selective inhibitor of cGMP phosphodiesterase 5. Bioorg Med Chem Lett. 2002 Sep 2;12(17):2313-6. DMRV5YE RU https://pubmed.ncbi.nlm.nih.gov/12161123 DMRV5YE DI DMRV5YE DMRV5YE DN KURARINOL DMRV5YE MI TTVIAT9 DMRV5YE MN Phosphodiesterase 4B (PDE4B) DMRV5YE MT DTT DMRV5YE MA Inhibitor DMRV5YE RN A prenylated flavonol, sophoflavescenol: a potent and selective inhibitor of cGMP phosphodiesterase 5. Bioorg Med Chem Lett. 2002 Sep 2;12(17):2313-6. DMRV5YE RU https://pubmed.ncbi.nlm.nih.gov/12161123 DMRV5YE DI DMRV5YE DMRV5YE DN KURARINOL DMRV5YE MI TTJ0IQB DMRV5YE MN Phosphodiesterase 5A (PDE5A) DMRV5YE MT DTT DMRV5YE MA Inhibitor DMRV5YE RN A prenylated flavonol, sophoflavescenol: a potent and selective inhibitor of cGMP phosphodiesterase 5. Bioorg Med Chem Lett. 2002 Sep 2;12(17):2313-6. DMRV5YE RU https://pubmed.ncbi.nlm.nih.gov/12161123 DMH0G8W DI DMH0G8W DMH0G8W DN Kurarinone DMH0G8W MI TT8JRS7 DMH0G8W MN Beta-secretase (BACE) DMH0G8W MT DTT DMH0G8W MA Inhibitor DMH0G8W RN BACE1 inhibitory effects of lavandulyl flavanones from Sophora flavescens. Bioorg Med Chem. 2008 Jul 15;16(14):6669-74. DMH0G8W RU https://pubmed.ncbi.nlm.nih.gov/18565755 DMH0G8W DI DMH0G8W DMH0G8W DN Kurarinone DMH0G8W MI TTF8JAT DMH0G8W MN SLC5A2 messenger RNA (SLC5A2 mRNA) DMH0G8W MT DTT DMH0G8W MA Inhibitor DMH0G8W RN Na+-glucose cotransporter (SGLT) inhibitory flavonoids from the roots of Sophora flavescens. Bioorg Med Chem. 2007 May 15;15(10):3445-9. DMH0G8W RU https://pubmed.ncbi.nlm.nih.gov/17374486 DMH0G8W DI DMH0G8W DMH0G8W DN Kurarinone DMH0G8W MI TT2UE56 DMH0G8W MN Sodium/glucose cotransporter 1 (SGLT1) DMH0G8W MT DTT DMH0G8W MA Inhibitor DMH0G8W RN Na+-glucose cotransporter (SGLT) inhibitory flavonoids from the roots of Sophora flavescens. Bioorg Med Chem. 2007 May 15;15(10):3445-9. DMH0G8W RU https://pubmed.ncbi.nlm.nih.gov/17374486 DMPKDJ4 DI DMPKDJ4 DMPKDJ4 DN KUR-CXCR4 DMPKDJ4 MI TTBID49 DMPKDJ4 MN C-X-C chemokine receptor type 4 (CXCR4) DMPKDJ4 MT DTT DMPKDJ4 MA Modulator DMPKDJ4 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 71). DMPKDJ4 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=71 DMCFHPD DI DMCFHPD DMCFHPD DN KUSHENOL A DMCFHPD MI TT8JRS7 DMCFHPD MN Beta-secretase (BACE) DMCFHPD MT DTT DMCFHPD MA Inhibitor DMCFHPD RN BACE1 inhibitory effects of lavandulyl flavanones from Sophora flavescens. Bioorg Med Chem. 2008 Jul 15;16(14):6669-74. DMCFHPD RU https://pubmed.ncbi.nlm.nih.gov/18565755 DMY13UR DI DMY13UR DMY13UR DN Kushenol N DMY13UR MI TTF8JAT DMY13UR MN SLC5A2 messenger RNA (SLC5A2 mRNA) DMY13UR MT DTT DMY13UR MA Inhibitor DMY13UR RN Na+-glucose cotransporter (SGLT) inhibitory flavonoids from the roots of Sophora flavescens. Bioorg Med Chem. 2007 May 15;15(10):3445-9. DMY13UR RU https://pubmed.ncbi.nlm.nih.gov/17374486 DMY13UR DI DMY13UR DMY13UR DN Kushenol N DMY13UR MI TT2UE56 DMY13UR MN Sodium/glucose cotransporter 1 (SGLT1) DMY13UR MT DTT DMY13UR MA Inhibitor DMY13UR RN Na+-glucose cotransporter (SGLT) inhibitory flavonoids from the roots of Sophora flavescens. Bioorg Med Chem. 2007 May 15;15(10):3445-9. DMY13UR RU https://pubmed.ncbi.nlm.nih.gov/17374486 DMVQDNR DI DMVQDNR DMVQDNR DN kuwanon H DMVQDNR MI TTHYDUM DMVQDNR MN Bombesin receptor (BS) DMVQDNR MT DTT DMVQDNR MA Antagonist DMVQDNR RN Non-peptide bombesin receptor antagonists, kuwanon G and H, isolated from mulberry. Biochem Biophys Res Commun. 1995 Aug 15;213(2):594-9. DMVQDNR RU https://pubmed.ncbi.nlm.nih.gov/7646517 DMVQDNR DI DMVQDNR DMVQDNR DN kuwanon H DMVQDNR MI TTC1MVT DMVQDNR MN Gastrin-releasing peptide receptor (GRPR) DMVQDNR MT DTT DMVQDNR MA Antagonist DMVQDNR RN Non-peptide bombesin receptor antagonists, kuwanon G and H, isolated from mulberry. Biochem Biophys Res Commun. 1995 Aug 15;213(2):594-9. DMVQDNR RU https://pubmed.ncbi.nlm.nih.gov/7646517 DMFSUJB DI DMFSUJB DMFSUJB DN Kuwanon J DMFSUJB MI TTELIN2 DMFSUJB MN PTPN1 messenger RNA (PTPN1 mRNA) DMFSUJB MT DTT DMFSUJB MA Inhibitor DMFSUJB RN Protein tyrosine phosphatase 1B inhibitors isolated from Morus bombycis. Bioorg Med Chem Lett. 2009 Dec 1;19(23):6759-61. DMFSUJB RU https://pubmed.ncbi.nlm.nih.gov/19846295 DMX4D1Q DI DMX4D1Q DMX4D1Q DN Kuwanon L DMX4D1Q MI TTELIN2 DMX4D1Q MN PTPN1 messenger RNA (PTPN1 mRNA) DMX4D1Q MT DTT DMX4D1Q MA Inhibitor DMX4D1Q RN Protein tyrosine phosphatase 1B inhibitors from Morus root bark. Bioorg Med Chem Lett. 2006 Mar 1;16(5):1426-9. DMX4D1Q RU https://pubmed.ncbi.nlm.nih.gov/16356713 DMEZOT9 DI DMEZOT9 DMEZOT9 DN Kuwanon R DMEZOT9 MI TTELIN2 DMEZOT9 MN PTPN1 messenger RNA (PTPN1 mRNA) DMEZOT9 MT DTT DMEZOT9 MA Inhibitor DMEZOT9 RN Protein tyrosine phosphatase 1B inhibitors isolated from Morus bombycis. Bioorg Med Chem Lett. 2009 Dec 1;19(23):6759-61. DMEZOT9 RU https://pubmed.ncbi.nlm.nih.gov/19846295 DM84M20 DI DM84M20 DM84M20 DN Kuwanon V DM84M20 MI TTELIN2 DM84M20 MN PTPN1 messenger RNA (PTPN1 mRNA) DM84M20 MT DTT DM84M20 MA Inhibitor DM84M20 RN Protein tyrosine phosphatase 1B inhibitors isolated from Morus bombycis. Bioorg Med Chem Lett. 2009 Dec 1;19(23):6759-61. DM84M20 RU https://pubmed.ncbi.nlm.nih.gov/19846295 DM7RFUC DI DM7RFUC DM7RFUC DN KwFwLL-NH2 DM7RFUC MI TTWDC17 DM7RFUC MN Growth hormone secretagogue receptor 1 (GHSR) DM7RFUC MT DTT DM7RFUC MA Inhibitor DM7RFUC RN Identification of an efficacy switch region in the ghrelin receptor responsible for interchange between agonism and inverse agonism. J Biol Chem. 2007 May 25;282(21):15799-811. DM7RFUC RU https://pubmed.ncbi.nlm.nih.gov/17371869 DMA9VBD DI DMA9VBD DMA9VBD DN KY-382 DMA9VBD MI TTMF541 DMA9VBD MN Liver carboxylesterase (CES1) DMA9VBD MT DTT DMA9VBD MA Modulator DMA9VBD RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2592). DMA9VBD RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2592 DM3MID9 DI DM3MID9 DM3MID9 DN KYS-05001 DM3MID9 MI TT729IR DM3MID9 MN Voltage-gated calcium channel alpha Cav3.1 (CACNA1G) DM3MID9 MT DTT DM3MID9 MA Inhibitor DM3MID9 RN Discovery of potent T-type calcium channel blocker. Bioorg Med Chem Lett. 2007 Nov 1;17(21):5740-3. DM3MID9 RU https://pubmed.ncbi.nlm.nih.gov/17869104 DM3MID9 DI DM3MID9 DM3MID9 DN KYS-05001 DM3MID9 MI TTZPWGN DM3MID9 MN Voltage-gated calcium channel alpha Cav3.2 (CACNA1H) DM3MID9 MT DTT DM3MID9 MA Inhibitor DM3MID9 RN 3,4-Dihydroquinazoline derivatives as novel selective T-type Ca2+ channel blockers. Bioorg Med Chem Lett. 2004 Jul 5;14(13):3379-84. DM3MID9 RU https://pubmed.ncbi.nlm.nih.gov/15177437 DM1JU8F DI DM1JU8F DM1JU8F DN KYS-05040 DM1JU8F MI TT729IR DM1JU8F MN Voltage-gated calcium channel alpha Cav3.1 (CACNA1G) DM1JU8F MT DTT DM1JU8F MA Inhibitor DM1JU8F RN 3,4-Dihydroquinazoline derivatives as novel selective T-type Ca2+ channel blockers. Bioorg Med Chem Lett. 2004 Jul 5;14(13):3379-84. DM1JU8F RU https://pubmed.ncbi.nlm.nih.gov/15177437 DM1JU8F DI DM1JU8F DM1JU8F DN KYS-05040 DM1JU8F MI TTZPWGN DM1JU8F MN Voltage-gated calcium channel alpha Cav3.2 (CACNA1H) DM1JU8F MT DTT DM1JU8F MA Inhibitor DM1JU8F RN 3,4-Dihydroquinazoline derivatives as novel selective T-type Ca2+ channel blockers. Bioorg Med Chem Lett. 2004 Jul 5;14(13):3379-84. DM1JU8F RU https://pubmed.ncbi.nlm.nih.gov/15177437 DMVA6LH DI DMVA6LH DMVA6LH DN KYS-05041 DMVA6LH MI TT729IR DMVA6LH MN Voltage-gated calcium channel alpha Cav3.1 (CACNA1G) DMVA6LH MT DTT DMVA6LH MA Inhibitor DMVA6LH RN 3D pharmacophore based virtual screening of T-type calcium channel blockers. Bioorg Med Chem. 2007 Jan 15;15(2):1091-105. DMVA6LH RU https://pubmed.ncbi.nlm.nih.gov/17074493 DMVA6LH DI DMVA6LH DMVA6LH DN KYS-05041 DMVA6LH MI TTZPWGN DMVA6LH MN Voltage-gated calcium channel alpha Cav3.2 (CACNA1H) DMVA6LH MT DTT DMVA6LH MA Inhibitor DMVA6LH RN 3,4-Dihydroquinazoline derivatives as novel selective T-type Ca2+ channel blockers. Bioorg Med Chem Lett. 2004 Jul 5;14(13):3379-84. DMVA6LH RU https://pubmed.ncbi.nlm.nih.gov/15177437 DMM6G4H DI DMM6G4H DMM6G4H DN KYS-05042 DMM6G4H MI TT729IR DMM6G4H MN Voltage-gated calcium channel alpha Cav3.1 (CACNA1G) DMM6G4H MT DTT DMM6G4H MA Inhibitor DMM6G4H RN T-type Ca2+ channel blockers suppress the growth of human cancer cells. Bioorg Med Chem Lett. 2008 Jul 15;18(14):3899-901. DMM6G4H RU https://pubmed.ncbi.nlm.nih.gov/18585035 DMM6G4H DI DMM6G4H DMM6G4H DN KYS-05042 DMM6G4H MI TTZPWGN DMM6G4H MN Voltage-gated calcium channel alpha Cav3.2 (CACNA1H) DMM6G4H MT DTT DMM6G4H MA Inhibitor DMM6G4H RN 3,4-Dihydroquinazoline derivatives as novel selective T-type Ca2+ channel blockers. Bioorg Med Chem Lett. 2004 Jul 5;14(13):3379-84. DMM6G4H RU https://pubmed.ncbi.nlm.nih.gov/15177437 DMXR3V4 DI DMXR3V4 DMXR3V4 DN KYS-05050 DMXR3V4 MI TT729IR DMXR3V4 MN Voltage-gated calcium channel alpha Cav3.1 (CACNA1G) DMXR3V4 MT DTT DMXR3V4 MA Inhibitor DMXR3V4 RN Synthesis and biological evaluation of novel T-type calcium channel blockers. Bioorg Med Chem Lett. 2007 Jan 15;17(2):471-5. DMXR3V4 RU https://pubmed.ncbi.nlm.nih.gov/17064894 DMXR3V4 DI DMXR3V4 DMXR3V4 DN KYS-05050 DMXR3V4 MI TTZPWGN DMXR3V4 MN Voltage-gated calcium channel alpha Cav3.2 (CACNA1H) DMXR3V4 MT DTT DMXR3V4 MA Inhibitor DMXR3V4 RN Synthesis and biological evaluation of novel T-type calcium channel blockers. Bioorg Med Chem Lett. 2007 Jan 15;17(2):471-5. DMXR3V4 RU https://pubmed.ncbi.nlm.nih.gov/17064894 DMRVOT7 DI DMRVOT7 DMRVOT7 DN KYS-05055 DMRVOT7 MI TT729IR DMRVOT7 MN Voltage-gated calcium channel alpha Cav3.1 (CACNA1G) DMRVOT7 MT DTT DMRVOT7 MA Inhibitor DMRVOT7 RN T-type Ca2+ channel blockers suppress the growth of human cancer cells. Bioorg Med Chem Lett. 2008 Jul 15;18(14):3899-901. DMRVOT7 RU https://pubmed.ncbi.nlm.nih.gov/18585035 DMP6S0L DI DMP6S0L DMP6S0L DN KYS-05056 DMP6S0L MI TT729IR DMP6S0L MN Voltage-gated calcium channel alpha Cav3.1 (CACNA1G) DMP6S0L MT DTT DMP6S0L MA Inhibitor DMP6S0L RN T-type Ca2+ channel blockers suppress the growth of human cancer cells. Bioorg Med Chem Lett. 2008 Jul 15;18(14):3899-901. DMP6S0L RU https://pubmed.ncbi.nlm.nih.gov/18585035 DM7BYG8 DI DM7BYG8 DM7BYG8 DN KYS-05057 DM7BYG8 MI TT729IR DM7BYG8 MN Voltage-gated calcium channel alpha Cav3.1 (CACNA1G) DM7BYG8 MT DTT DM7BYG8 MA Inhibitor DM7BYG8 RN T-type Ca2+ channel blockers suppress the growth of human cancer cells. Bioorg Med Chem Lett. 2008 Jul 15;18(14):3899-901. DM7BYG8 RU https://pubmed.ncbi.nlm.nih.gov/18585035 DM61GPQ DI DM61GPQ DM61GPQ DN KYS-05064 DM61GPQ MI TT729IR DM61GPQ MN Voltage-gated calcium channel alpha Cav3.1 (CACNA1G) DM61GPQ MT DTT DM61GPQ MA Inhibitor DM61GPQ RN 3D pharmacophore based virtual screening of T-type calcium channel blockers. Bioorg Med Chem. 2007 Jan 15;15(2):1091-105. DM61GPQ RU https://pubmed.ncbi.nlm.nih.gov/17074493 DMA8LFD DI DMA8LFD DMA8LFD DN KYS-05065 DMA8LFD MI TT729IR DMA8LFD MN Voltage-gated calcium channel alpha Cav3.1 (CACNA1G) DMA8LFD MT DTT DMA8LFD MA Inhibitor DMA8LFD RN T-type Ca2+ channel blockers suppress the growth of human cancer cells. Bioorg Med Chem Lett. 2008 Jul 15;18(14):3899-901. DMA8LFD RU https://pubmed.ncbi.nlm.nih.gov/18585035 DMRJQY3 DI DMRJQY3 DMRJQY3 DN KYS-05070 DMRJQY3 MI TT729IR DMRJQY3 MN Voltage-gated calcium channel alpha Cav3.1 (CACNA1G) DMRJQY3 MT DTT DMRJQY3 MA Inhibitor DMRJQY3 RN Growth inhibition of human cancer cells in vitro by T-type calcium channel blockers. Bioorg Med Chem Lett. 2006 Oct 1;16(19):5014-7. DMRJQY3 RU https://pubmed.ncbi.nlm.nih.gov/16876410 DM7K5Z3 DI DM7K5Z3 DM7K5Z3 DN KYS-05071 DM7K5Z3 MI TT729IR DM7K5Z3 MN Voltage-gated calcium channel alpha Cav3.1 (CACNA1G) DM7K5Z3 MT DTT DM7K5Z3 MA Inhibitor DM7K5Z3 RN Growth inhibition of human cancer cells in vitro by T-type calcium channel blockers. Bioorg Med Chem Lett. 2006 Oct 1;16(19):5014-7. DM7K5Z3 RU https://pubmed.ncbi.nlm.nih.gov/16876410 DMYRWQ3 DI DMYRWQ3 DMYRWQ3 DN KYS-05074 DMYRWQ3 MI TT729IR DMYRWQ3 MN Voltage-gated calcium channel alpha Cav3.1 (CACNA1G) DMYRWQ3 MT DTT DMYRWQ3 MA Inhibitor DMYRWQ3 RN Growth inhibition of human cancer cells in vitro by T-type calcium channel blockers. Bioorg Med Chem Lett. 2006 Oct 1;16(19):5014-7. DMYRWQ3 RU https://pubmed.ncbi.nlm.nih.gov/16876410 DMHW40F DI DMHW40F DMHW40F DN KYS-05077 DMHW40F MI TT729IR DMHW40F MN Voltage-gated calcium channel alpha Cav3.1 (CACNA1G) DMHW40F MT DTT DMHW40F MA Inhibitor DMHW40F RN Synthesis and biological evaluation of novel T-type calcium channel blockers. Bioorg Med Chem Lett. 2007 Jan 15;17(2):471-5. DMHW40F RU https://pubmed.ncbi.nlm.nih.gov/17064894 DMHW40F DI DMHW40F DMHW40F DN KYS-05077 DMHW40F MI TTZPWGN DMHW40F MN Voltage-gated calcium channel alpha Cav3.2 (CACNA1H) DMHW40F MT DTT DMHW40F MA Inhibitor DMHW40F RN Synthesis and biological evaluation of novel T-type calcium channel blockers. Bioorg Med Chem Lett. 2007 Jan 15;17(2):471-5. DMHW40F RU https://pubmed.ncbi.nlm.nih.gov/17064894 DM57BXZ DI DM57BXZ DM57BXZ DN KYS-05080 DM57BXZ MI TT729IR DM57BXZ MN Voltage-gated calcium channel alpha Cav3.1 (CACNA1G) DM57BXZ MT DTT DM57BXZ MA Inhibitor DM57BXZ RN T-type Ca2+ channel blockers suppress the growth of human cancer cells. Bioorg Med Chem Lett. 2008 Jul 15;18(14):3899-901. DM57BXZ RU https://pubmed.ncbi.nlm.nih.gov/18585035 DM57BXZ DI DM57BXZ DM57BXZ DN KYS-05080 DM57BXZ MI TTZPWGN DM57BXZ MN Voltage-gated calcium channel alpha Cav3.2 (CACNA1H) DM57BXZ MT DTT DM57BXZ MA Inhibitor DM57BXZ RN Synthesis and biological evaluation of novel T-type calcium channel blockers. Bioorg Med Chem Lett. 2007 Jan 15;17(2):471-5. DM57BXZ RU https://pubmed.ncbi.nlm.nih.gov/17064894 DM92RHP DI DM92RHP DM92RHP DN KYS-05090 DM92RHP MI TT4FDG6 DM92RHP MN Voltage-gated calcium channel alpha Cav2.2 (CACNA1B) DM92RHP MT DTT DM92RHP MA Inhibitor DM92RHP RN Discovery of potent T-type calcium channel blocker. Bioorg Med Chem Lett. 2007 Nov 1;17(21):5740-3. DM92RHP RU https://pubmed.ncbi.nlm.nih.gov/17869104 DM92RHP DI DM92RHP DM92RHP DN KYS-05090 DM92RHP MI TT729IR DM92RHP MN Voltage-gated calcium channel alpha Cav3.1 (CACNA1G) DM92RHP MT DTT DM92RHP MA Inhibitor DM92RHP RN T-type Ca2+ channel blockers suppress the growth of human cancer cells. Bioorg Med Chem Lett. 2008 Jul 15;18(14):3899-901. DM92RHP RU https://pubmed.ncbi.nlm.nih.gov/18585035 DMB73Y4 DI DMB73Y4 DMB73Y4 DN L 691121 DMB73Y4 MI TT1VOHK DMB73Y4 MN Potassium channel unspecific (KC) DMB73Y4 MT DTT DMB73Y4 MA Modulator DMB73Y4 RN Embryotoxic effects of L-691,121, a class III antiarrhythmic agent, in rats. Arch Toxicol. 1994;69(1):65-71. DMB73Y4 RU https://www.ncbi.nlm.nih.gov/pubmed/7717857 DMK07MI DI DMK07MI DMK07MI DN L-(cis)-diltiazem DMK07MI MI TTHIQMC DMK07MI MN Cyclic nucleotide-gated channel alpha-1 (CNGA1) DMK07MI MT DTT DMK07MI MA Blocker (channel blocker) DMK07MI RN A new subunit of the cyclic nucleotide-gated cation channel in retinal rods. Nature. 1993 Apr 22;362(6422):764-7. DMK07MI RU https://pubmed.ncbi.nlm.nih.gov/7682292 DMK07MI DI DMK07MI DMK07MI DN L-(cis)-diltiazem DMK07MI MI TT8SJGB DMK07MI MN Cyclic nucleotide-gated channel alpha-2 (CNGA2) DMK07MI MT DTT DMK07MI MA Blocker (channel blocker) DMK07MI RN Primary structure and functional expression of a cyclic nucleotide-activated channel from olfactory neurons. Nature. 1990 Sep 13;347(6289):184-7. DMK07MI RU https://pubmed.ncbi.nlm.nih.gov/1697649 DMK07MI DI DMK07MI DMK07MI DN L-(cis)-diltiazem DMK07MI MI TTW0QOV DMK07MI MN Cyclic nucleotide-gated channel alpha-3 (CNGA3) DMK07MI MT DTT DMK07MI MA Inhibitor DMK07MI RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 396). DMK07MI RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=396 DMK07MI DI DMK07MI DMK07MI DN L-(cis)-diltiazem DMK07MI MI TT0LJCG DMK07MI MN Cyclic nucleotide-gated channel beta-3 (CNGB3) DMK07MI MT DTT DMK07MI MA Blocker (channel blocker) DMK07MI RN Molecular cloning and functional characterization of a new modulatory cyclic nucleotide-gated channel subunit from mouse retina. J Neurosci. 2000 Feb 15;20(4):1324-32. DMK07MI RU https://pubmed.ncbi.nlm.nih.gov/10662822 DMK07MI DI DMK07MI DMK07MI DN L-(cis)-diltiazem DMK07MI MI TTJ0SO4 DMK07MI MN Voltage-gated calcium channel alpha Cav1.4 (CACNA1F) DMK07MI MT DTT DMK07MI MA Inhibitor (gating inhibitor) DMK07MI RN Functional characterization of the L-type Ca2+ channel Cav1.4alpha1 from mouse retina. Invest Ophthalmol Vis Sci. 2004 Feb;45(2):708-13. DMK07MI RU https://pubmed.ncbi.nlm.nih.gov/14744918 DMYWD6C DI DMYWD6C DMYWD6C DN L000021649 DMYWD6C MI TTUTJGQ DMYWD6C MN Vascular endothelial growth factor receptor 2 (KDR) DMYWD6C MT DTT DMYWD6C MA Inhibitor DMYWD6C RN Optimization of a pyrazolo[1,5-a]pyrimidine class of KDR kinase inhibitors: improvements in physical properties enhance cellular activity and pharm... Bioorg Med Chem Lett. 2002 Dec 16;12(24):3537-41. DMYWD6C RU https://pubmed.ncbi.nlm.nih.gov/12443771 DM9KWUR DI DM9KWUR DM9KWUR DN L023103 DM9KWUR MI TTSCIUP DM9KWUR MN Oxytocin receptor (OTR) DM9KWUR MT DTT DM9KWUR MA Antagonist DM9KWUR RN Discovery and development of a new class of potent, selective, orally active oxytocin receptor antagonists. J Med Chem. 2005 Dec 1;48(24):7882-905. DM9KWUR RU https://pubmed.ncbi.nlm.nih.gov/16302826 DM9KWUR DI DM9KWUR DM9KWUR DN L023103 DM9KWUR MI TT4TFGN DM9KWUR MN Vasopressin V1a receptor (V1AR) DM9KWUR MT DTT DM9KWUR MA Antagonist DM9KWUR RN Discovery and development of a new class of potent, selective, orally active oxytocin receptor antagonists. J Med Chem. 2005 Dec 1;48(24):7882-905. DM9KWUR RU https://pubmed.ncbi.nlm.nih.gov/16302826 DMQR6ZX DI DMQR6ZX DMQR6ZX DN L-054,522 DMQR6ZX MI TTZ6T9E DMQR6ZX MN Somatostatin receptor type 2 (SSTR2) DMQR6ZX MT DTT DMQR6ZX MA Agonist DMQR6ZX RN Synthesis and biological activities of potent peptidomimetics selective for somatostatin receptor subtype 2. Proc Natl Acad Sci U S A. 1998 Sep 1;95(18):10836-41. DMQR6ZX RU https://pubmed.ncbi.nlm.nih.gov/9724791 DMXB7G5 DI DMXB7G5 DMXB7G5 DN L-054852 DMXB7G5 MI TTZ6T9E DMXB7G5 MN Somatostatin receptor type 2 (SSTR2) DMXB7G5 MT DTT DMXB7G5 MA Agonist DMXB7G5 RN Treatment strategies for acromegaly. Expert Opin Emerg Drugs. 2005 Nov;10(4):875-90. DMXB7G5 RU https://pubmed.ncbi.nlm.nih.gov/16262568 DMWNJV0 DI DMWNJV0 DMWNJV0 DN L-136662 DMWNJV0 MI TTGP7BY DMWNJV0 MN Monoamine oxidase type B (MAO-B) DMWNJV0 MT DTT DMWNJV0 MA Inhibitor DMWNJV0 RN Identification of novel monoamine oxidase B inhibitors by structure-based virtual screening. Bioorg Med Chem Lett. 2010 Sep 1;20(17):5295-8. DMWNJV0 RU https://pubmed.ncbi.nlm.nih.gov/20650633 DMVGX7Z DI DMVGX7Z DMVGX7Z DN L-152,804 DMVGX7Z MI TTY6EWA DMVGX7Z MN Neuropeptide Y receptor type 5 (NPY5R) DMVGX7Z MT DTT DMVGX7Z MA Antagonist DMVGX7Z RN L-152,804: orally active and selective neuropeptide Y Y5 receptor antagonist. Biochem Biophys Res Commun. 2000 May 27;272(1):169-73. DMVGX7Z RU https://pubmed.ncbi.nlm.nih.gov/10872822 DMOX8JE DI DMOX8JE DMOX8JE DN L-159093 DMOX8JE MI TT8DBY3 DMOX8JE MN Angiotensin II receptor type-1 (AGTR1) DMOX8JE MT DTT DMOX8JE MA Inhibitor DMOX8JE RN Designed multiple ligands. An emerging drug discovery paradigm. J Med Chem. 2005 Oct 20;48(21):6523-43. DMOX8JE RU https://pubmed.ncbi.nlm.nih.gov/16220969 DMOX8JE DI DMOX8JE DMOX8JE DN L-159093 DMOX8JE MI TTQVOEI DMOX8JE MN Angiotensin II receptor type-2 (AGTR2) DMOX8JE MT DTT DMOX8JE MA Inhibitor DMOX8JE RN A potent, orally active, balanced affinity angiotensin II AT1 antagonist and AT2 binding inhibitor. J Med Chem. 1993 Oct 15;36(21):3207-10. DMOX8JE RU https://pubmed.ncbi.nlm.nih.gov/8230109 DMZOW96 DI DMZOW96 DMZOW96 DN L-162313 DMZOW96 MI TT8DBY3 DMZOW96 MN Angiotensin II receptor type-1 (AGTR1) DMZOW96 MT DTT DMZOW96 MA Inhibitor DMZOW96 RN Selective angiotensin II AT2 receptor agonists: Benzamide structure-activity relationships. Bioorg Med Chem. 2008 Jul 15;16(14):6841-9. DMZOW96 RU https://pubmed.ncbi.nlm.nih.gov/18599297 DMZOW96 DI DMZOW96 DMZOW96 DN L-162313 DMZOW96 MI TTQVOEI DMZOW96 MN Angiotensin II receptor type-2 (AGTR2) DMZOW96 MT DTT DMZOW96 MA Inhibitor DMZOW96 RN Selective angiotensin II AT(2) receptor agonists with reduced CYP 450 inhibition. Bioorg Med Chem. 2010 Jun 15;18(12):4570-90. DMZOW96 RU https://pubmed.ncbi.nlm.nih.gov/20493713 DMWSP6H DI DMWSP6H DMWSP6H DN L-162782 DMWSP6H MI TT8DBY3 DMWSP6H MN Angiotensin II receptor type-1 (AGTR1) DMWSP6H MT DTT DMWSP6H MA Inhibitor DMWSP6H RN Selective angiotensin II AT2 receptor agonists: Benzamide structure-activity relationships. Bioorg Med Chem. 2008 Jul 15;16(14):6841-9. DMWSP6H RU https://pubmed.ncbi.nlm.nih.gov/18599297 DMYC7AK DI DMYC7AK DMYC7AK DN L-163,101 DMYC7AK MI TT8DBY3 DMYC7AK MN Angiotensin II receptor type-1 (AGTR1) DMYC7AK MT DTT DMYC7AK MA Agonist DMYC7AK RN Structural model of antagonist and agonist binding to the angiotensin II, AT1 subtype, G protein coupled receptor. Chem Biol. 1994 Dec;1(4):211-21. DMYC7AK RU https://pubmed.ncbi.nlm.nih.gov/9383393 DMZP7YM DI DMZP7YM DMZP7YM DN L-165041 DMZP7YM MI TT2JWF6 DMZP7YM MN Peroxisome proliferator-activated receptor delta (PPARD) DMZP7YM MT DTT DMZP7YM MA Agonist DMZP7YM RN Novel peroxisome proliferator-activated receptor (PPAR) gamma and PPARdelta ligands produce distinct biological effects. J Biol Chem. 1999 Mar 5;274(10):6718-25. DMZP7YM RU https://pubmed.ncbi.nlm.nih.gov/10037770 DMKBSGN DI DMKBSGN DMKBSGN DN L-165461 DMKBSGN MI TTJ584C DMKBSGN MN Peroxisome proliferator-activated receptor alpha (PPARA) DMKBSGN MT DTT DMKBSGN MA Inhibitor DMKBSGN RN Phenylacetic acid derivatives as hPPAR agonists. Bioorg Med Chem Lett. 2003 Apr 7;13(7):1277-80. DMKBSGN RU https://pubmed.ncbi.nlm.nih.gov/12657263 DMKBSGN DI DMKBSGN DMKBSGN DN L-165461 DMKBSGN MI TT2JWF6 DMKBSGN MN Peroxisome proliferator-activated receptor delta (PPARD) DMKBSGN MT DTT DMKBSGN MA Inhibitor DMKBSGN RN Phenylacetic acid derivatives as hPPAR agonists. Bioorg Med Chem Lett. 2003 Apr 7;13(7):1277-80. DMKBSGN RU https://pubmed.ncbi.nlm.nih.gov/12657263 DMKBSGN DI DMKBSGN DMKBSGN DN L-165461 DMKBSGN MI TTT2SVW DMKBSGN MN PPAR-gamma messenger RNA (PPARG mRNA) DMKBSGN MT DTT DMKBSGN MA Inhibitor DMKBSGN RN Phenylacetic acid derivatives as hPPAR agonists. Bioorg Med Chem Lett. 2003 Apr 7;13(7):1277-80. DMKBSGN RU https://pubmed.ncbi.nlm.nih.gov/12657263 DM3UGMD DI DM3UGMD DM3UGMD DN L-168049 DM3UGMD MI TT9O6WS DM3UGMD MN Glucagon receptor (GCGR) DM3UGMD MT DTT DM3UGMD MA Antagonist DM3UGMD RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 251). DM3UGMD RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=251 DMZ4KO0 DI DMZ4KO0 DMZ4KO0 DN L17 DMZ4KO0 MI TT5FH9Y DMZ4KO0 MN Human immunodeficiency virus Integrase (HIV IN) DMZ4KO0 MT DTT DMZ4KO0 MA Inhibitor DMZ4KO0 RN Specific inhibition of human immunodeficiency virus type 1 (HIV-1) integration in cell culture: putative inhibitors of HIV-1 integrase. Antimicrob Agents Chemother. 2001 Sep;45(9):2510-6. DMZ4KO0 RU https://pubmed.ncbi.nlm.nih.gov/11502522 DMEK65F DI DMEK65F DMEK65F DN L-249313 DMEK65F MI TTK25J1 DMEK65F MN Adenosine A1 receptor (ADORA1) DMEK65F MT DTT DMEK65F MA Inhibitor DMEK65F RN 2-Alkynyl-8-aryl-9-methyladenines as novel adenosine receptor antagonists: their synthesis and structure-activity relationships toward hepatic gluc... J Med Chem. 2001 Jan 18;44(2):170-9. DMEK65F RU https://pubmed.ncbi.nlm.nih.gov/11170626 DMEK65F DI DMEK65F DMEK65F DN L-249313 DMEK65F MI TTJFY5U DMEK65F MN Adenosine A3 receptor (ADORA3) DMEK65F MT DTT DMEK65F MA Inhibitor DMEK65F RN The utilization of a unified pharmacophore query in the discovery of new antagonists of the adenosine receptor family. Bioorg Med Chem Lett. 2000 Jan 3;10(1):31-4. DMEK65F RU https://pubmed.ncbi.nlm.nih.gov/10636237 DMV6018 DI DMV6018 DMV6018 DN L-269,289 DMV6018 MI TTX20QP DMV6018 MN Geranylgeranyl transferase I (GGTase-I) DMV6018 MT DTT DMV6018 MA Inhibitor DMV6018 RN Geranylgeranyltransferase I of Candida albicans: null mutants or enzyme inhibitors produce unexpected phenotypes. J Bacteriol. 2000 Feb;182(3):704-13. DMV6018 RU https://pubmed.ncbi.nlm.nih.gov/10633104 DMWQCRD DI DMWQCRD DMWQCRD DN L-2-Amino-4-(Guanidinooxy)Butyric Acid DMWQCRD MI TTCM4B3 DMWQCRD MN Nitric-oxide synthase endothelial (NOS3) DMWQCRD MT DTT DMWQCRD MA Inhibitor DMWQCRD RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMWQCRD RU https://pubmed.ncbi.nlm.nih.gov/17139284 DM1WMHO DI DM1WMHO DM1WMHO DN L-365,209 DM1WMHO MI TTSCIUP DM1WMHO MN Oxytocin receptor (OTR) DM1WMHO MT DTT DM1WMHO MA Antagonist DM1WMHO RN Characterization of the human oxytocin receptor stably expressed in 293 human embryonic kidney cells. Life Sci. 1995;57(24):2253-61. DM1WMHO RU https://pubmed.ncbi.nlm.nih.gov/7475979 DMGQE1B DI DMGQE1B DMGQE1B DN L-366,509 DMGQE1B MI TTSCIUP DMGQE1B MN Oxytocin receptor (OTR) DMGQE1B MT DTT DMGQE1B MA Antagonist DMGQE1B RN Characterization of the human oxytocin receptor stably expressed in 293 human embryonic kidney cells. Life Sci. 1995;57(24):2253-61. DMGQE1B RU https://pubmed.ncbi.nlm.nih.gov/7475979 DMAS5P8 DI DMAS5P8 DMAS5P8 DN L-366,682 DMAS5P8 MI TTSCIUP DMAS5P8 MN Oxytocin receptor (OTR) DMAS5P8 MT DTT DMAS5P8 MA Antagonist DMAS5P8 RN Characterization of the human oxytocin receptor stably expressed in 293 human embryonic kidney cells. Life Sci. 1995;57(24):2253-61. DMAS5P8 RU https://pubmed.ncbi.nlm.nih.gov/7475979 DM31NXF DI DM31NXF DM31NXF DN L-366,948 DM31NXF MI TTSCIUP DM31NXF MN Oxytocin receptor (OTR) DM31NXF MT DTT DM31NXF MA Antagonist DM31NXF RN Characterization of the human oxytocin receptor stably expressed in 293 human embryonic kidney cells. Life Sci. 1995;57(24):2253-61. DM31NXF RU https://pubmed.ncbi.nlm.nih.gov/7475979 DMQ369D DI DMQ369D DMQ369D DN L-367,773 DMQ369D MI TTSCIUP DMQ369D MN Oxytocin receptor (OTR) DMQ369D MT DTT DMQ369D MA Antagonist DMQ369D RN Characterization of the human oxytocin receptor stably expressed in 293 human embryonic kidney cells. Life Sci. 1995;57(24):2253-61. DMQ369D RU https://pubmed.ncbi.nlm.nih.gov/7475979 DMC1Z0L DI DMC1Z0L DMC1Z0L DN L-370,518 DMC1Z0L MI TT6L509 DMC1Z0L MN Coagulation factor IIa (F2) DMC1Z0L MT DTT DMC1Z0L MA Inhibitor DMC1Z0L RN Assessment of thrombin inhibitor efficacy in a novel rabbit model of simultaneous arterial and venous thrombosis. Thromb Haemost. 1998 Mar;79(3):656-62. DMC1Z0L RU https://pubmed.ncbi.nlm.nih.gov/9531058 DMQV974 DI DMQV974 DMQV974 DN L-372662 DMQV974 MI TTSCIUP DMQV974 MN Oxytocin receptor (OTR) DMQV974 MT DTT DMQV974 MA Inhibitor DMQV974 RN Oral oxytocin antagonists. J Med Chem. 2010 Sep 23;53(18):6525-38. DMQV974 RU https://pubmed.ncbi.nlm.nih.gov/20550119 DMQV974 DI DMQV974 DMQV974 DN L-372662 DMQV974 MI TT4TFGN DMQV974 MN Vasopressin V1a receptor (V1AR) DMQV974 MT DTT DMQV974 MA Inhibitor DMQV974 RN Oral oxytocin antagonists. J Med Chem. 2010 Sep 23;53(18):6525-38. DMQV974 RU https://pubmed.ncbi.nlm.nih.gov/20550119 DMQV974 DI DMQV974 DMQV974 DN L-372662 DMQV974 MI TTK8R02 DMQV974 MN Vasopressin V2 receptor (V2R) DMQV974 MT DTT DMQV974 MA Inhibitor DMQV974 RN Oral oxytocin antagonists. J Med Chem. 2010 Sep 23;53(18):6525-38. DMQV974 RU https://pubmed.ncbi.nlm.nih.gov/20550119 DMQWKPM DI DMQWKPM DMQWKPM DN L-375378 DMQWKPM MI TT2WR1T DMQWKPM MN Cationic trypsinogen (PRSS1) DMQWKPM MT DTT DMQWKPM MA Inhibitor DMQWKPM RN Small, low nanomolar, noncovalent thrombin inhibitors lacking a group to fill the 'distal binding pocket'. Bioorg Med Chem Lett. 2003 Jan 20;13(2):161-4. DMQWKPM RU https://pubmed.ncbi.nlm.nih.gov/12482415 DMQWKPM DI DMQWKPM DMQWKPM DN L-375378 DMQWKPM MI TT6L509 DMQWKPM MN Coagulation factor IIa (F2) DMQWKPM MT DTT DMQWKPM MA Inhibitor DMQWKPM RN Small, low nanomolar, noncovalent thrombin inhibitors lacking a group to fill the 'distal binding pocket'. Bioorg Med Chem Lett. 2003 Jan 20;13(2):161-4. DMQWKPM RU https://pubmed.ncbi.nlm.nih.gov/12482415 DM0P4V6 DI DM0P4V6 DM0P4V6 DN L-454560 DM0P4V6 MI TTZ97H5 DM0P4V6 MN Phosphodiesterase 4A (PDE4A) DM0P4V6 MT DTT DM0P4V6 MA Inhibitor DM0P4V6 RN The discovery and synthesis of highly potent subtype selective phosphodiesterase 4D inhibitors. Bioorg Med Chem Lett. 2010 Sep 15;20(18):5502-5. DM0P4V6 RU https://pubmed.ncbi.nlm.nih.gov/20709547 DM0P4V6 DI DM0P4V6 DM0P4V6 DN L-454560 DM0P4V6 MI TTVIAT9 DM0P4V6 MN Phosphodiesterase 4B (PDE4B) DM0P4V6 MT DTT DM0P4V6 MA Inhibitor DM0P4V6 RN The discovery and synthesis of highly potent subtype selective phosphodiesterase 4D inhibitors. Bioorg Med Chem Lett. 2010 Sep 15;20(18):5502-5. DM0P4V6 RU https://pubmed.ncbi.nlm.nih.gov/20709547 DM0P4V6 DI DM0P4V6 DM0P4V6 DN L-454560 DM0P4V6 MI TTSKMI8 DM0P4V6 MN Phosphodiesterase 4D (PDE4D) DM0P4V6 MT DTT DM0P4V6 MA Inhibitor DM0P4V6 RN The discovery and synthesis of highly potent subtype selective phosphodiesterase 4D inhibitors. Bioorg Med Chem Lett. 2010 Sep 15;20(18):5502-5. DM0P4V6 RU https://pubmed.ncbi.nlm.nih.gov/20709547 DMHL901 DI DMHL901 DMHL901 DN L-5-(bromovinyl)deoxyuridine DMHL901 MI TTP3QRF DMHL901 MN Thymidine kinase 1 (TK1) DMHL901 MT DTT DMHL901 MA Inhibitor DMHL901 RN Sensitivity of monkey B virus (Cercopithecine herpesvirus 1) to antiviral drugs: role of thymidine kinase in antiviral activities of substrate anal... Antimicrob Agents Chemother. 2007 Jun;51(6):2028-34. DMHL901 RU https://pubmed.ncbi.nlm.nih.gov/17438061 DM3Q0JL DI DM3Q0JL DM3Q0JL DN L-5-iodo-2'-deoxyuridine DM3Q0JL MI TTP3QRF DM3Q0JL MN Thymidine kinase 1 (TK1) DM3Q0JL MT DTT DM3Q0JL MA Inhibitor DM3Q0JL RN Sensitivity of monkey B virus (Cercopithecine herpesvirus 1) to antiviral drugs: role of thymidine kinase in antiviral activities of substrate anal... Antimicrob Agents Chemother. 2007 Jun;51(6):2028-34. DM3Q0JL RU https://pubmed.ncbi.nlm.nih.gov/17438061 DMENUOD DI DMENUOD DMENUOD DN L-644,698 DMENUOD MI TTNVEIR DMENUOD MN Prostaglandin D2 receptor (PTGDR) DMENUOD MT DTT DMENUOD MA Agonist DMENUOD RN A novel biological role for prostaglandin D2 is suggested by distribution studies of the rat DP prostanoid receptor. Eur J Pharmacol. 1999 Jul 14;377(1):101-15. DMENUOD RU https://pubmed.ncbi.nlm.nih.gov/10448933 DMA23LP DI DMA23LP DMA23LP DN L-652,343 DMA23LP MI TT2J34L DMA23LP MN Arachidonate 5-lipoxygenase (5-LOX) DMA23LP MT DTT DMA23LP MA Inhibitor DMA23LP RN Pharmacology of the dual inhibitor of cyclooxygenase and 5-lipoxygenase 3-hydroxy-5-trifluoromethyl-N-(2-(2-thienyl)-2-phenyl-ethenyl)-benzo (b)thiophene-2-carboxamide. Arzneimittelforschung. 1988 Mar;38(3):372-8. DMA23LP RU https://pubmed.ncbi.nlm.nih.gov/3132928 DM360VU DI DM360VU DM360VU DN L-652731 DM360VU MI TTQL5VC DM360VU MN Platelet-activating factor receptor (PTAFR) DM360VU MT DTT DM360VU MA Inhibitor DM360VU RN Development, synthesis, and biological evaluation of (-)-trans-(2S,5S)-2-[3-[(2-oxopropyl)sulfonyl]-4-n-propoxy-5-(3- hydroxypropoxy)-phenyl]-5-(3,... J Med Chem. 1992 Sep 18;35(19):3474-82. DM360VU RU https://pubmed.ncbi.nlm.nih.gov/1404229 DM4CDIB DI DM4CDIB DM4CDIB DN L-655708 DM4CDIB MI TT1MPAY DM4CDIB MN GABA(A) receptor alpha-1 (GABRA1) DM4CDIB MT DTT DM4CDIB MA Inhibitor DM4CDIB RN 3-phenyl-6-(2-pyridyl)methyloxy-1,2,4-triazolo[3,4-a]phthalazines and analogues: high-affinity gamma-aminobutyric acid-A benzodiazepine receptor li... J Med Chem. 2004 Mar 25;47(7):1807-22. DM4CDIB RU https://pubmed.ncbi.nlm.nih.gov/15027873 DM4CDIB DI DM4CDIB DM4CDIB DN L-655708 DM4CDIB MI TTBMV1G DM4CDIB MN GABA(A) receptor alpha-2 (GABRA2) DM4CDIB MT DTT DM4CDIB MA Inhibitor DM4CDIB RN 3-phenyl-6-(2-pyridyl)methyloxy-1,2,4-triazolo[3,4-a]phthalazines and analogues: high-affinity gamma-aminobutyric acid-A benzodiazepine receptor li... J Med Chem. 2004 Mar 25;47(7):1807-22. DM4CDIB RU https://pubmed.ncbi.nlm.nih.gov/15027873 DM4CDIB DI DM4CDIB DM4CDIB DN L-655708 DM4CDIB MI TT37EDJ DM4CDIB MN GABA(A) receptor alpha-3 (GABRA3) DM4CDIB MT DTT DM4CDIB MA Inhibitor DM4CDIB RN 3-phenyl-6-(2-pyridyl)methyloxy-1,2,4-triazolo[3,4-a]phthalazines and analogues: high-affinity gamma-aminobutyric acid-A benzodiazepine receptor li... J Med Chem. 2004 Mar 25;47(7):1807-22. DM4CDIB RU https://pubmed.ncbi.nlm.nih.gov/15027873 DM4CDIB DI DM4CDIB DM4CDIB DN L-655708 DM4CDIB MI TTNZPQ1 DM4CDIB MN GABA(A) receptor alpha-5 (GABRA5) DM4CDIB MT DTT DM4CDIB MA Inhibitor DM4CDIB RN 3-phenyl-6-(2-pyridyl)methyloxy-1,2,4-triazolo[3,4-a]phthalazines and analogues: high-affinity gamma-aminobutyric acid-A benzodiazepine receptor li... J Med Chem. 2004 Mar 25;47(7):1807-22. DM4CDIB RU https://pubmed.ncbi.nlm.nih.gov/15027873 DM4CDIB DI DM4CDIB DM4CDIB DN L-655708 DM4CDIB MI TT06RH5 DM4CDIB MN GABA(A) receptor gamma-2 (GABRG2) DM4CDIB MT DTT DM4CDIB MA Inhibitor DM4CDIB RN 3-phenyl-6-(2-pyridyl)methyloxy-1,2,4-triazolo[3,4-a]phthalazines and analogues: high-affinity gamma-aminobutyric acid-A benzodiazepine receptor li... J Med Chem. 2004 Mar 25;47(7):1807-22. DM4CDIB RU https://pubmed.ncbi.nlm.nih.gov/15027873 DM4CDIB DI DM4CDIB DM4CDIB DN L-655708 DM4CDIB MI TTNJYV2 DM4CDIB MN Gamma-aminobutyric acid receptor (GAR) DM4CDIB MT DTT DM4CDIB MA Inhibitor DM4CDIB RN 3-phenyl-6-(2-pyridyl)methyloxy-1,2,4-triazolo[3,4-a]phthalazines and analogues: high-affinity gamma-aminobutyric acid-A benzodiazepine receptor li... J Med Chem. 2004 Mar 25;47(7):1807-22. DM4CDIB RU https://pubmed.ncbi.nlm.nih.gov/15027873 DMY0IQ6 DI DMY0IQ6 DMY0IQ6 DN L-658,758 DMY0IQ6 MI TTPLTSQ DMY0IQ6 MN Neutrophil elastase (NE) DMY0IQ6 MT DTT DMY0IQ6 MA Inhibitor DMY0IQ6 RN Neutrophil elastase promotes lung microvascular injury and proteolysis of endothelial cadherins. Am J Physiol. 1998 Aug;275(2 Pt 2):H385-92. DMY0IQ6 RU https://pubmed.ncbi.nlm.nih.gov/9683424 DMDF0KZ DI DMDF0KZ DMDF0KZ DN L-659,699 DMDF0KZ MI TTQF4TK DMDF0KZ MN Hydroxymethylglutaryl-CoA synthase 1 (HMGCS1) DMDF0KZ MT DTT DMDF0KZ MA Inhibitor DMDF0KZ RN Inhibition of 3-hydroxy-3-methylglutaryl-CoA synthase and cholesterol biosynthesis by beta-lactone inhibitors and binding of these inhibitors to the enzyme. Biochem J. 1993 Feb 1;289 ( Pt 3):889-95. DMDF0KZ RU https://pubmed.ncbi.nlm.nih.gov/8094614 DMP4QCJ DI DMP4QCJ DMP4QCJ DN L-671,480 DMP4QCJ MI TTDMBF5 DMP4QCJ MN Arachidonate 5-lipoxygenase activating protein (FLAP) DMP4QCJ MT DTT DMP4QCJ MA Inhibitor DMP4QCJ RN 5-Lipoxygenase-activating protein is the target of a quinoline class of leukotriene synthesis inhibitors. Mol Pharmacol. 1991 Jul;40(1):22-7. DMP4QCJ RU https://pubmed.ncbi.nlm.nih.gov/1857337 DMJUQT1 DI DMJUQT1 DMJUQT1 DN L-685,818 DMJUQT1 MI TTA4LDE DMJUQT1 MN Calcineurin (PPP3CA) DMJUQT1 MT DTT DMJUQT1 MA Inhibitor DMJUQT1 RN Synergistic antifungal activities of bafilomycin A(1), fluconazole, and the pneumocandin MK-0991/caspofungin acetate (L-743,873) with calcineurin inhibitors FK506 and L-685,818 against Cryptococcus neoformans. Antimicrob Agents Chemother. 2000 Mar;44(3):739-46. DMJUQT1 RU https://pubmed.ncbi.nlm.nih.gov/10681348 DMJUQT1 DI DMJUQT1 DMJUQT1 DN L-685,818 DMJUQT1 MI TTQW87Y DMJUQT1 MN Opioid receptor kappa (OPRK1) DMJUQT1 MT DTT DMJUQT1 MA Antagonist DMJUQT1 RN FK-506-binding protein: three-dimensional structure of the complex with the antagonist L-685,818. J Biol Chem. 1993 May 25;268(15):11335-9. DMJUQT1 RU https://pubmed.ncbi.nlm.nih.gov/7684380 DMCH3ZK DI DMCH3ZK DMCH3ZK DN L-689,037 DMCH3ZK MI TTDMBF5 DMCH3ZK MN Arachidonate 5-lipoxygenase activating protein (FLAP) DMCH3ZK MT DTT DMCH3ZK MA Inhibitor DMCH3ZK RN 5-Lipoxygenase-activating protein is the target of a novel hybrid of two classes of leukotriene biosynthesis inhibitors. Mol Pharmacol. 1992 Feb;41(2):267-72. DMCH3ZK RU https://pubmed.ncbi.nlm.nih.gov/1538707 DM42BGX DI DM42BGX DM42BGX DN L-689065 DM42BGX MI TTSJ6Q4 DM42BGX MN LOX-5 messenger RNA (ALOX5 mRNA) DM42BGX MT DTT DM42BGX MA Inhibitor DM42BGX RN Substituted thiopyrano[2,3,4-c,d]indoles as potent, selective, and orally active inhibitors of 5-lipoxygenase. Synthesis and biological evaluation ... J Med Chem. 1993 Sep 17;36(19):2771-87. DM42BGX RU https://pubmed.ncbi.nlm.nih.gov/8410991 DMAB1RW DI DMAB1RW DMAB1RW DN L-692289 DMAB1RW MI TTZMS1L DMAB1RW MN Fungal Papulacandin B resistance protein 1 (Fung FKS1) DMAB1RW MT DTT DMAB1RW MA Inhibitor DMAB1RW RN Antifungal lipopeptides: Structure-activity relationships of 3-hydroxyglutamine-modified pneumocandin B0 derivatives, Bioorg. Med. Chem. Lett. 5(20):2357-2362 (1995). DMAB1RW RU http://www.sciencedirect.com/science/article/pii/0960894X9500407K DMMUYHX DI DMMUYHX DMMUYHX DN L-693612 DMMUYHX MI TTHQPL7 DMMUYHX MN Carbonic anhydrase I (CA-I) DMMUYHX MT DTT DMMUYHX MA Modulator DMMUYHX RN Dose-dependent pharmacokinetics of L-693,612, a carbonic anhydrase inhibitor, following oral administration in rats. Pharm Res. 1994 Mar;11(3):438-41. DMMUYHX RU https://pubmed.ncbi.nlm.nih.gov/8008713 DM92X5T DI DM92X5T DM92X5T DN L-702-539 DM92X5T MI TTSJ6Q4 DM92X5T MN LOX-5 messenger RNA (ALOX5 mRNA) DM92X5T MT DTT DM92X5T MA Inhibitor DM92X5T RN Substituted (pyridylmethoxy)naphthalenes as potent and orally active 5-lipoxygenase inhibitors; synthesis, biological profile, and pharmacokinetics... J Med Chem. 1997 Aug 29;40(18):2866-75. DM92X5T RU https://pubmed.ncbi.nlm.nih.gov/9288168 DMUOPRT DI DMUOPRT DMUOPRT DN L-703,606 DMUOPRT MI TTZPO1L DMUOPRT MN Substance-P receptor (TACR1) DMUOPRT MT DTT DMUOPRT MA Antagonist DMUOPRT RN The unpredicted high affinities of a large number of naturally occurring tachykinins for chimeric NK1/NK3 receptors suggest a role for an inhibitory domain in determining receptor specificity. J BiolChem. 1996 Aug 23;271(34):20250-7. DMUOPRT RU https://pubmed.ncbi.nlm.nih.gov/8702757 DMWYIJ3 DI DMWYIJ3 DMWYIJ3 DN L-708,906 DMWYIJ3 MI TT5FH9Y DMWYIJ3 MN Human immunodeficiency virus Integrase (HIV IN) DMWYIJ3 MT DTT DMWYIJ3 MA Inhibitor DMWYIJ3 RN Specific inhibition of human immunodeficiency virus type 1 (HIV-1) integration in cell culture: putative inhibitors of HIV-1 integrase. Antimicrob Agents Chemother. 2001 Sep;45(9):2510-6. DMWYIJ3 RU https://pubmed.ncbi.nlm.nih.gov/11502522 DM3QUCS DI DM3QUCS DM3QUCS DN L-708474 DM3QUCS MI TTCG0AL DM3QUCS MN Cholecystokinin receptor type A (CCKAR) DM3QUCS MT DTT DM3QUCS MA Inhibitor DM3QUCS RN High-affinity and potent, water-soluble 5-amino-1,4-benzodiazepine CCKB/gastrin receptor antagonists containing a cationic solubilizing group. J Med Chem. 1994 Mar 18;37(6):719-21. DM3QUCS RU https://pubmed.ncbi.nlm.nih.gov/8145219 DMLMV9P DI DMLMV9P DMLMV9P DN L-708568 DMLMV9P MI TTZPO1L DMLMV9P MN Substance-P receptor (TACR1) DMLMV9P MT DTT DMLMV9P MA Inhibitor DMLMV9P RN N-acyl-L-tryptophan benzyl esters: potent substance P receptor antagonists. J Med Chem. 1993 Jul 9;36(14):2044-5. DMLMV9P RU https://pubmed.ncbi.nlm.nih.gov/8393115 DM9KCYQ DI DM9KCYQ DM9KCYQ DN L-709,587 DM9KCYQ MI TTMW94E DM9KCYQ MN FK506-binding protein 1A (FKBP1A) DM9KCYQ MT DTT DM9KCYQ MA Inhibitor DM9KCYQ RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DM9KCYQ RU https://pubmed.ncbi.nlm.nih.gov/17139284 DM7YVUT DI DM7YVUT DM7YVUT DN L-731,988 DM7YVUT MI TT5FH9Y DM7YVUT MN Human immunodeficiency virus Integrase (HIV IN) DM7YVUT MT DTT DM7YVUT MA Inhibitor DM7YVUT RN Specific inhibition of human immunodeficiency virus type 1 (HIV-1) integration in cell culture: putative inhibitors of HIV-1 integrase. Antimicrob Agents Chemother. 2001 Sep;45(9):2510-6. DM7YVUT RU https://pubmed.ncbi.nlm.nih.gov/11502522 DM8WCUY DI DM8WCUY DM8WCUY DN L-731120 DM8WCUY MI TTFQEO5 DM8WCUY MN Squalene synthetase (FDFT1) DM8WCUY MT DTT DM8WCUY MA Inhibitor DM8WCUY RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 645). DM8WCUY RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=645 DMTHLUN DI DMTHLUN DMTHLUN DN L-731128 DMTHLUN MI TTFQEO5 DMTHLUN MN Squalene synthetase (FDFT1) DMTHLUN MT DTT DMTHLUN MA Inhibitor DMTHLUN RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 645). DMTHLUN RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=645 DMDNVTF DI DMDNVTF DMDNVTF DN L-734115 DMDNVTF MI TTJA1ZO DMDNVTF MN ITGB3 messenger RNA (ITGB3 mRNA) DMDNVTF MT DTT DMDNVTF MA Inhibitor DMDNVTF RN Platelet glycoprotein IIb-IIIa antagonists as prototypical integrin blockers: novel parenteral and potential oral antithrombotic agents. J Med Chem. 2000 Sep 21;43(19):3453-73. DMDNVTF RU https://pubmed.ncbi.nlm.nih.gov/10999999 DMY60MG DI DMY60MG DMY60MG DN L-735,821 DMY60MG MI TT846HF DMY60MG MN Voltage-gated potassium channel Kv7.1 (KCNQ1) DMY60MG MT DTT DMY60MG MA Blocker DMY60MG RN Molecular determinants of KCNQ1 channel block by a benzodiazepine. Mol Pharmacol. 2003 Jul;64(1):70-7. DMY60MG RU https://pubmed.ncbi.nlm.nih.gov/12815162 DM8BVJQ DI DM8BVJQ DM8BVJQ DN L-735021 DM8BVJQ MI TTFQEO5 DM8BVJQ MN Squalene synthetase (FDFT1) DM8BVJQ MT DTT DM8BVJQ MA Inhibitor DM8BVJQ RN Structure-activity relationships of C1 and C6 side chains of zaragozic acid A derivatives. J Med Chem. 1994 Nov 11;37(23):4031-51. DM8BVJQ RU https://pubmed.ncbi.nlm.nih.gov/7966163 DMJNLSI DI DMJNLSI DMJNLSI DN L-736281 DMJNLSI MI TTZPO1L DMJNLSI MN Substance-P receptor (TACR1) DMJNLSI MT DTT DMJNLSI MA Inhibitor DMJNLSI RN N-heteroaryl-2-phenyl-3-(benzyloxy)piperidines: a novel class of potent orally active human NK1 antagonists. J Med Chem. 1996 Jul 19;39(15):2907-14. DMJNLSI RU https://pubmed.ncbi.nlm.nih.gov/8709125 DMM5AYL DI DMM5AYL DMM5AYL DN L-736380 DMM5AYL MI TTCG0AL DMM5AYL MN Cholecystokinin receptor type A (CCKAR) DMM5AYL MT DTT DMM5AYL MA Antagonist DMM5AYL RN Controlled modification of acidity in cholecystokinin B receptor antagonists: N-(1,4-benzodiazepin-3-yl)-N'-[3-(tetrazol-5-ylamino) phenyl]ureas. J Med Chem. 1996 Feb 16;39(4):842-9. DMM5AYL RU https://pubmed.ncbi.nlm.nih.gov/8632408 DMAHC9Z DI DMAHC9Z DMAHC9Z DN L-739750 DMAHC9Z MI TT7WZIJ DMAHC9Z MN CAAX farnesyltransferase beta (FNTB) DMAHC9Z MT DTT DMAHC9Z MA Inhibitor DMAHC9Z RN Ras farnesyltransferase: a new therapeutic target. J Med Chem. 1997 Sep 12;40(19):2971-90. DMAHC9Z RU https://pubmed.ncbi.nlm.nih.gov/9301658 DM5IAXN DI DM5IAXN DM5IAXN DN L-739758 DM5IAXN MI TTJA1ZO DM5IAXN MN ITGB3 messenger RNA (ITGB3 mRNA) DM5IAXN MT DTT DM5IAXN MA Inhibitor DM5IAXN RN Platelet glycoprotein IIb-IIIa antagonists as prototypical integrin blockers: novel parenteral and potential oral antithrombotic agents. J Med Chem. 2000 Sep 21;43(19):3453-73. DM5IAXN RU https://pubmed.ncbi.nlm.nih.gov/10999999 DMVA2D0 DI DMVA2D0 DMVA2D0 DN L-740093 DMVA2D0 MI TTCG0AL DMVA2D0 MN Cholecystokinin receptor type A (CCKAR) DMVA2D0 MT DTT DMVA2D0 MA Inhibitor DMVA2D0 RN C5-piperazinyl-1,4-benzodiazepines, water-soluble, orally bioa vailable CCKB/gastrin receptor antagonists, Bioorg. Med. Chem. Lett. 5(24):3023-3026 (1995). DMVA2D0 RU http://www.sciencedirect.com/science/article/pii/0960894X95005300 DMCYQJF DI DMCYQJF DMCYQJF DN L-741626 DMCYQJF MI TTEX248 DMCYQJF MN Dopamine D2 receptor (D2R) DMCYQJF MT DTT DMCYQJF MA Inhibitor DMCYQJF RN Synthesis and characterization of selective dopamine D2 receptor antagonists. 2. Azaindole, benzofuran, and benzothiophene analogs of L-741,626. Bioorg Med Chem. 2010 Jul 15;18(14):5291-300. DMCYQJF RU https://pubmed.ncbi.nlm.nih.gov/20542439 DMCYQJF DI DMCYQJF DMCYQJF DN L-741626 DMCYQJF MI TT4C8EA DMCYQJF MN Dopamine D3 receptor (D3R) DMCYQJF MT DTT DMCYQJF MA Inhibitor DMCYQJF RN Synthesis and characterization of selective dopamine D2 receptor antagonists. 2. Azaindole, benzofuran, and benzothiophene analogs of L-741,626. Bioorg Med Chem. 2010 Jul 15;18(14):5291-300. DMCYQJF RU https://pubmed.ncbi.nlm.nih.gov/20542439 DMCYQJF DI DMCYQJF DMCYQJF DN L-741626 DMCYQJF MI TTE0A2F DMCYQJF MN Dopamine D4 receptor (D4R) DMCYQJF MT DTT DMCYQJF MA Inhibitor DMCYQJF RN Synthesis and characterization of selective dopamine D2 receptor antagonists. 2. Azaindole, benzofuran, and benzothiophene analogs of L-741,626. Bioorg Med Chem. 2010 Jul 15;18(14):5291-300. DMCYQJF RU https://pubmed.ncbi.nlm.nih.gov/20542439 DMP75YK DI DMP75YK DMP75YK DN L-741742 DMP75YK MI TT4C8EA DMP75YK MN Dopamine D3 receptor (D3R) DMP75YK MT DTT DMP75YK MA Inhibitor DMP75YK RN 5-(4-Chlorophenyl)-4-methyl-3-(1-(2-phenylethyl)piperidin-4-yl)isoxazole: a potent, selective antagonist at human cloned dopamine D4 receptors. J Med Chem. 1996 May 10;39(10):1943-5. DMP75YK RU https://pubmed.ncbi.nlm.nih.gov/8642551 DMP75YK DI DMP75YK DMP75YK DN L-741742 DMP75YK MI TTE0A2F DMP75YK MN Dopamine D4 receptor (D4R) DMP75YK MT DTT DMP75YK MA Inhibitor DMP75YK RN 5-(4-Chlorophenyl)-4-methyl-3-(1-(2-phenylethyl)piperidin-4-yl)isoxazole: a potent, selective antagonist at human cloned dopamine D4 receptors. J Med Chem. 1996 May 10;39(10):1943-5. DMP75YK RU https://pubmed.ncbi.nlm.nih.gov/8642551 DMP75YK DI DMP75YK DMP75YK DN L-741742 DMP75YK MI TTRK8B9 DMP75YK MN Sodium channel unspecific (NaC) DMP75YK MT DTT DMP75YK MA Inhibitor DMP75YK RN 1-(3-Cyanobenzylpiperidin-4-yl)-5-methyl-4-phenyl-1, 3-dihydroimidazol-2-one: a selective high-affinity antagonist for the human dopamine D(4) rece... J Med Chem. 1999 Jul 15;42(14):2706-15. DMP75YK RU https://pubmed.ncbi.nlm.nih.gov/10411491 DMP75YK DI DMP75YK DMP75YK DN L-741742 DMP75YK MI TTAXZ0K DMP75YK MN Voltage-gated sodium channel alpha Nav1.3 (SCN3A) DMP75YK MT DTT DMP75YK MA Inhibitor DMP75YK RN 1-(3-Cyanobenzylpiperidin-4-yl)-5-methyl-4-phenyl-1, 3-dihydroimidazol-2-one: a selective high-affinity antagonist for the human dopamine D(4) rece... J Med Chem. 1999 Jul 15;42(14):2706-15. DMP75YK RU https://pubmed.ncbi.nlm.nih.gov/10411491 DMRC8MT DI DMRC8MT DMRC8MT DN L-746233 DMRC8MT MI TTJA1ZO DMRC8MT MN ITGB3 messenger RNA (ITGB3 mRNA) DMRC8MT MT DTT DMRC8MT MA Inhibitor DMRC8MT RN Platelet glycoprotein IIb-IIIa antagonists as prototypical integrin blockers: novel parenteral and potential oral antithrombotic agents. J Med Chem. 2000 Sep 21;43(19):3453-73. DMRC8MT RU https://pubmed.ncbi.nlm.nih.gov/10999999 DMUY8MP DI DMUY8MP DMUY8MP DN L-746530 DMUY8MP MI TTSJ6Q4 DMUY8MP MN LOX-5 messenger RNA (ALOX5 mRNA) DMUY8MP MT DTT DMUY8MP MA Inhibitor DMUY8MP RN Substituted coumarins as potent 5-lipoxygenase inhibitors. Bioorg Med Chem Lett. 2006 May 1;16(9):2528-31. DMUY8MP RU https://pubmed.ncbi.nlm.nih.gov/16464579 DMBPWSJ DI DMBPWSJ DMBPWSJ DN L-747201 DMBPWSJ MI TTK8CXU DMBPWSJ MN 5-HT 1B receptor (HTR1B) DMBPWSJ MT DTT DMBPWSJ MA Inhibitor DMBPWSJ RN Selective, orally active 5-HT1D receptor agonists as potential antimigraine agents. J Med Chem. 1997 Oct 24;40(22):3501-3. DMBPWSJ RU https://pubmed.ncbi.nlm.nih.gov/9357515 DMBPWSJ DI DMBPWSJ DMBPWSJ DN L-747201 DMBPWSJ MI TT6MSOK DMBPWSJ MN 5-HT 1D receptor (HTR1D) DMBPWSJ MT DTT DMBPWSJ MA Inhibitor DMBPWSJ RN Selective, orally active 5-HT1D receptor agonists as potential antimigraine agents. J Med Chem. 1997 Oct 24;40(22):3501-3. DMBPWSJ RU https://pubmed.ncbi.nlm.nih.gov/9357515 DMEGU5J DI DMEGU5J DMEGU5J DN L748328 DMEGU5J MI TTMXGCW DMEGU5J MN Adrenergic receptor beta-3 (ADRB3) DMEGU5J MT DTT DMEGU5J MA Antagonist DMEGU5J RN Potent and selective human beta(3)-adrenergic receptor antagonists. J Pharmacol Exp Ther. 1999 Aug;290(2):649-55. DMEGU5J RU https://pubmed.ncbi.nlm.nih.gov/10411574 DM7CPBU DI DM7CPBU DM7CPBU DN L-748337 DM7CPBU MI TTMXGCW DM7CPBU MN Adrenergic receptor beta-3 (ADRB3) DM7CPBU MT DTT DM7CPBU MA Antagonist DM7CPBU RN Potent and selective human beta(3)-adrenergic receptor antagonists. J Pharmacol Exp Ther. 1999 Aug;290(2):649-55. DM7CPBU RU https://pubmed.ncbi.nlm.nih.gov/10411574 DMJZXAF DI DMJZXAF DMJZXAF DN L-748780 DMJZXAF MI TTVKILB DMJZXAF MN Prostaglandin G/H synthase 2 (COX-2) DMJZXAF MT DTT DMJZXAF MA Inhibitor DMJZXAF RN From indomethacin to a selective COX-2 inhibitor: Development of indolalkanoic acids as potent and selective cyclooxygenase-2 inhibitors, Bioorg. Med. Chem. Lett. 6(6):725-730 (1996). DMJZXAF RU http://www.sciencedirect.com/science/article/pii/0960894X9600100X DM2WUKF DI DM2WUKF DM2WUKF DN L-750,667 DM2WUKF MI TTE0A2F DM2WUKF MN Dopamine D4 receptor (D4R) DM2WUKF MT DTT DM2WUKF MA Antagonist DM2WUKF RN Nonconserved residues in the second transmembrane-spanning domain of the D(4) dopamine receptor are molecular determinants of D(4)-selective pharmacology. Mol Pharmacol. 2000 Jan;57(1):144-52. DM2WUKF RU https://pubmed.ncbi.nlm.nih.gov/10617689 DM9QAP4 DI DM9QAP4 DM9QAP4 DN L-750034 DM9QAP4 MI TTJA1ZO DM9QAP4 MN ITGB3 messenger RNA (ITGB3 mRNA) DM9QAP4 MT DTT DM9QAP4 MA Inhibitor DM9QAP4 RN Molecular model of the alpha(IIb)beta(3) integrin. J Med Chem. 2003 Dec 4;46(25):5316-25. DM9QAP4 RU https://pubmed.ncbi.nlm.nih.gov/14640540 DMEQWSB DI DMEQWSB DMEQWSB DN L-756568 DMEQWSB MI TTJA1ZO DMEQWSB MN ITGB3 messenger RNA (ITGB3 mRNA) DMEQWSB MT DTT DMEQWSB MA Inhibitor DMEQWSB RN Platelet glycoprotein IIb-IIIa antagonists as prototypical integrin blockers: novel parenteral and potential oral antithrombotic agents. J Med Chem. 2000 Sep 21;43(19):3453-73. DMEQWSB RU https://pubmed.ncbi.nlm.nih.gov/10999999 DMQJNDX DI DMQJNDX DMQJNDX DN L-759,633 DMQJNDX MI TTMSFAW DMQJNDX MN Cannabinoid receptor 2 (CB2) DMQJNDX MT DTT DMQJNDX MA Agonist DMQJNDX RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 57). DMQJNDX RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=57 DM5SOR4 DI DM5SOR4 DM5SOR4 DN L-759,656 DM5SOR4 MI TTMSFAW DM5SOR4 MN Cannabinoid receptor 2 (CB2) DM5SOR4 MT DTT DM5SOR4 MA Agonist DM5SOR4 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 57). DM5SOR4 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=57 DMA9VDN DI DMA9VDN DMA9VDN DN L-760790 DMA9VDN MI TT6MSOK DMA9VDN MN 5-HT 1D receptor (HTR1D) DMA9VDN MT DTT DMA9VDN MA Inhibitor DMA9VDN RN 3-(Piperazinylpropyl)indoles: selective, orally bioavailable h5-HT1D receptor agonists as potential antimigraine agents. J Med Chem. 1999 Feb 25;42(4):691-705. DMA9VDN RU https://pubmed.ncbi.nlm.nih.gov/10052976 DM0A2MG DI DM0A2MG DM0A2MG DN L-761000 DM0A2MG MI TTVKILB DM0A2MG MN Prostaglandin G/H synthase 2 (COX-2) DM0A2MG MT DTT DM0A2MG MA Inhibitor DM0A2MG RN From indomethacin to a selective COX-2 inhibitor: Development of indolalkanoic acids as potent and selective cyclooxygenase-2 inhibitors, Bioorg. Med. Chem. Lett. 6(6):725-730 (1996). DM0A2MG RU http://www.sciencedirect.com/science/article/pii/0960894X9600100X DMG5KVS DI DMG5KVS DMG5KVS DN L-764406 DMG5KVS MI TTT2SVW DMG5KVS MN PPAR-gamma messenger RNA (PPARG mRNA) DMG5KVS MT DTT DMG5KVS MA Agonist DMG5KVS RN L-764406 is a partial agonist of human peroxisome proliferator-activated receptor gamma. The role of Cys313 in ligand binding. J Biol Chem. 1999 Mar 19;274(12):7913-22. DMG5KVS RU https://pubmed.ncbi.nlm.nih.gov/10075686 DMH0TUZ DI DMH0TUZ DMH0TUZ DN L-765314 DMH0TUZ MI TTNGILX DMH0TUZ MN Adrenergic receptor alpha-1A (ADRA1A) DMH0TUZ MT DTT DMH0TUZ MA Inhibitor DMH0TUZ RN Pharmacophore identification of alpha(1A)-adrenoceptor antagonists. Bioorg Med Chem Lett. 2005 Feb 1;15(3):657-64. DMH0TUZ RU https://pubmed.ncbi.nlm.nih.gov/15664832 DM96SPJ DI DM96SPJ DM96SPJ DN L-767679 DM96SPJ MI TTJA1ZO DM96SPJ MN ITGB3 messenger RNA (ITGB3 mRNA) DM96SPJ MT DTT DM96SPJ MA Inhibitor DM96SPJ RN Platelet glycoprotein IIb-IIIa antagonists as prototypical integrin blockers: novel parenteral and potential oral antithrombotic agents. J Med Chem. 2000 Sep 21;43(19):3453-73. DM96SPJ RU https://pubmed.ncbi.nlm.nih.gov/10999999 DM5O0CM DI DM5O0CM DM5O0CM DN L-772,405 DM5O0CM MI TTSQIFT DM5O0CM MN 5-HT 1A receptor (HTR1A) DM5O0CM MT DTT DM5O0CM MA Agonist DM5O0CM RN 3-[3-(Piperidin-1-yl)propyl]indoles as highly selective h5-HT(1D) receptor agonists. J Med Chem. 1999 Dec 2;42(24):4981-5001. DM5O0CM RU https://pubmed.ncbi.nlm.nih.gov/10585208 DM5O0CM DI DM5O0CM DM5O0CM DN L-772,405 DM5O0CM MI TTK8CXU DM5O0CM MN 5-HT 1B receptor (HTR1B) DM5O0CM MT DTT DM5O0CM MA Agonist DM5O0CM RN 3-[3-(Piperidin-1-yl)propyl]indoles as highly selective h5-HT(1D) receptor agonists. J Med Chem. 1999 Dec 2;42(24):4981-5001. DM5O0CM RU https://pubmed.ncbi.nlm.nih.gov/10585208 DM5O0CM DI DM5O0CM DM5O0CM DN L-772,405 DM5O0CM MI TT6MSOK DM5O0CM MN 5-HT 1D receptor (HTR1D) DM5O0CM MT DTT DM5O0CM MA Antagonist DM5O0CM RN 3-[3-(Piperidin-1-yl)propyl]indoles as highly selective h5-HT(1D) receptor agonists. J Med Chem. 1999 Dec 2;42(24):4981-5001. DM5O0CM RU https://pubmed.ncbi.nlm.nih.gov/10585208 DMMUAW5 DI DMMUAW5 DMMUAW5 DN L-779,976 DMMUAW5 MI TTZ6T9E DMMUAW5 MN Somatostatin receptor type 2 (SSTR2) DMMUAW5 MT DTT DMMUAW5 MA Agonist DMMUAW5 RN Rapid identification of subtype-selective agonists of the somatostatin receptor through combinatorial chemistry. Science. 1998 Oct 23;282(5389):737-40. DMMUAW5 RU https://pubmed.ncbi.nlm.nih.gov/9784130 DM51B74 DI DM51B74 DM51B74 DN L-779450 DM51B74 MI TT0EOB8 DM51B74 MN B-Raf messenger RNA (BRAF mRNA) DM51B74 MT DTT DM51B74 MA Inhibitor DM51B74 RN The identification of potent and selective imidazole-based inhibitors of B-Raf kinase. Bioorg Med Chem Lett. 2006 Jan 15;16(2):378-81. DM51B74 RU https://pubmed.ncbi.nlm.nih.gov/16260133 DM51B74 DI DM51B74 DM51B74 DN L-779450 DM51B74 MI TTRSMW9 DM51B74 MN Glycogen synthase kinase-3 beta (GSK-3B) DM51B74 MT DTT DM51B74 MA Inhibitor DM51B74 RN The identification of potent and selective imidazole-based inhibitors of B-Raf kinase. Bioorg Med Chem Lett. 2006 Jan 15;16(2):378-81. DM51B74 RU https://pubmed.ncbi.nlm.nih.gov/16260133 DM51B74 DI DM51B74 DM51B74 DN L-779450 DM51B74 MI TT860QF DM51B74 MN LCK tyrosine protein kinase (LCK) DM51B74 MT DTT DM51B74 MA Inhibitor DM51B74 RN The identification of potent and selective imidazole-based inhibitors of B-Raf kinase. Bioorg Med Chem Lett. 2006 Jan 15;16(2):378-81. DM51B74 RU https://pubmed.ncbi.nlm.nih.gov/16260133 DM51B74 DI DM51B74 DM51B74 DN L-779450 DM51B74 MI TTQBR95 DM51B74 MN Stress-activated protein kinase 2a (p38 alpha) DM51B74 MT DTT DM51B74 MA Inhibitor DM51B74 RN The identification of potent and selective imidazole-based inhibitors of B-Raf kinase. Bioorg Med Chem Lett. 2006 Jan 15;16(2):378-81. DM51B74 RU https://pubmed.ncbi.nlm.nih.gov/16260133 DM51B74 DI DM51B74 DM51B74 DN L-779450 DM51B74 MI TT73U6C DM51B74 MN Stress-activated protein kinase 2b (p38 beta) DM51B74 MT DTT DM51B74 MA Inhibitor DM51B74 RN The identification of potent and selective imidazole-based inhibitors of B-Raf kinase. Bioorg Med Chem Lett. 2006 Jan 15;16(2):378-81. DM51B74 RU https://pubmed.ncbi.nlm.nih.gov/16260133 DM6OTGE DI DM6OTGE DM6OTGE DN L-783483 DM6OTGE MI TTECBXN DM6OTGE MN Oxysterols receptor LXR-alpha (NR1H3) DM6OTGE MT DTT DM6OTGE MA Agonist DM6OTGE RN A novel liver X receptor agonist establishes species differences in the regulation of cholesterol 7alpha-hydroxylase (CYP7a). Endocrinology. 2002 Jul;143(7):2548-58. DM6OTGE RU https://pubmed.ncbi.nlm.nih.gov/12072387 DM6OTGE DI DM6OTGE DM6OTGE DN L-783483 DM6OTGE MI TTXA6PH DM6OTGE MN Oxysterols receptor LXR-beta (NR1H2) DM6OTGE MT DTT DM6OTGE MA Agonist DM6OTGE RN A novel liver X receptor agonist establishes species differences in the regulation of cholesterol 7alpha-hydroxylase (CYP7a). Endocrinology. 2002 Jul;143(7):2548-58. DM6OTGE RU https://pubmed.ncbi.nlm.nih.gov/12072387 DM6OTGE DI DM6OTGE DM6OTGE DN L-783483 DM6OTGE MI TT2JWF6 DM6OTGE MN Peroxisome proliferator-activated receptor delta (PPARD) DM6OTGE MT DTT DM6OTGE MA Agonist DM6OTGE RN Novel peroxisome proliferator-activated receptor (PPAR) gamma and PPARdelta ligands produce distinct biological effects. J Biol Chem. 1999 Mar 5;274(10):6718-25. DM6OTGE RU https://pubmed.ncbi.nlm.nih.gov/10037770 DM6OTGE DI DM6OTGE DM6OTGE DN L-783483 DM6OTGE MI TTT2SVW DM6OTGE MN PPAR-gamma messenger RNA (PPARG mRNA) DM6OTGE MT DTT DM6OTGE MA Agonist DM6OTGE RN Novel peroxisome proliferator-activated receptor (PPAR) gamma and PPARdelta ligands produce distinct biological effects. J Biol Chem. 1999 Mar 5;274(10):6718-25. DM6OTGE RU https://pubmed.ncbi.nlm.nih.gov/10037770 DMJKAQR DI DMJKAQR DMJKAQR DN L-790070 DMJKAQR MI TTAN5W2 DMJKAQR MN Raf messenger RNA (Raf mRNA) DMJKAQR MT DTT DMJKAQR MA Inhibitor DMJKAQR RN Design, synthesis, and biological evaluation of novel Tri- and tetrasubstituted imidazoles as highly potent and specific ATP-mimetic inhibitors of ... J Med Chem. 2008 Jul 24;51(14):4122-49. DMJKAQR RU https://pubmed.ncbi.nlm.nih.gov/18578517 DM5D892 DI DM5D892 DM5D892 DN L-791943 DM5D892 MI TTZ97H5 DM5D892 MN Phosphodiesterase 4A (PDE4A) DM5D892 MT DTT DM5D892 MA Inhibitor DM5D892 RN Discovery of L-791,943: a potent, selective, non emetic and orally active phosphodiesterase-4 inhibitor. Bioorg Med Chem Lett. 2002 Jun 3;12(11):1457-61. DM5D892 RU https://pubmed.ncbi.nlm.nih.gov/12031319 DMINOFE DI DMINOFE DMINOFE DN L-796,778 DMINOFE MI TTJX3UE DMINOFE MN Somatostatin receptor type 3 (SSTR3) DMINOFE MT DTT DMINOFE MA Agonist DMINOFE RN Rapid identification of subtype-selective agonists of the somatostatin receptor through combinatorial chemistry. Science. 1998 Oct 23;282(5389):737-40. DMINOFE RU https://pubmed.ncbi.nlm.nih.gov/9784130 DMWTGQM DI DMWTGQM DMWTGQM DN L-796449 DMWTGQM MI TTJ584C DMWTGQM MN Peroxisome proliferator-activated receptor alpha (PPARA) DMWTGQM MT DTT DMWTGQM MA Inhibitor DMWTGQM RN Phenylacetic acid derivatives as hPPAR agonists. Bioorg Med Chem Lett. 2003 Apr 7;13(7):1277-80. DMWTGQM RU https://pubmed.ncbi.nlm.nih.gov/12657263 DMWTGQM DI DMWTGQM DMWTGQM DN L-796449 DMWTGQM MI TT2JWF6 DMWTGQM MN Peroxisome proliferator-activated receptor delta (PPARD) DMWTGQM MT DTT DMWTGQM MA Inhibitor DMWTGQM RN Phenylacetic acid derivatives as hPPAR agonists. Bioorg Med Chem Lett. 2003 Apr 7;13(7):1277-80. DMWTGQM RU https://pubmed.ncbi.nlm.nih.gov/12657263 DMWTGQM DI DMWTGQM DMWTGQM DN L-796449 DMWTGQM MI TTT2SVW DMWTGQM MN PPAR-gamma messenger RNA (PPARG mRNA) DMWTGQM MT DTT DMWTGQM MA Inhibitor DMWTGQM RN Phenylacetic acid derivatives as hPPAR agonists. Bioorg Med Chem Lett. 2003 Apr 7;13(7):1277-80. DMWTGQM RU https://pubmed.ncbi.nlm.nih.gov/12657263 DM96ASN DI DM96ASN DM96ASN DN L-797,591 DM96ASN MI TTIND6G DM96ASN MN Somatostatin receptor type 1 (SSTR1) DM96ASN MT DTT DM96ASN MA Agonist DM96ASN RN Rapid identification of subtype-selective agonists of the somatostatin receptor through combinatorial chemistry. Science. 1998 Oct 23;282(5389):737-40. DM96ASN RU https://pubmed.ncbi.nlm.nih.gov/9784130 DM4FMGJ DI DM4FMGJ DM4FMGJ DN L-798,106 DM4FMGJ MI TTPNGDE DM4FMGJ MN Prostaglandin E2 receptor EP3 (PTGER3) DM4FMGJ MT DTT DM4FMGJ MA Antagonist DM4FMGJ RN Dual modulation of urinary bladder activity and urine flow by prostanoid EP3 receptors in the conscious rat. Br J Pharmacol. 2009 Sep;158(1):372-81. DM4FMGJ RU https://pubmed.ncbi.nlm.nih.gov/19486006 DMWBRDK DI DMWBRDK DMWBRDK DN L-803,087 DMWBRDK MI TTAE1BR DMWBRDK MN Somatostatin receptor type 4 (SSTR4) DMWBRDK MT DTT DMWBRDK MA Agonist DMWBRDK RN Rapid identification of subtype-selective agonists of the somatostatin receptor through combinatorial chemistry. Science. 1998 Oct 23;282(5389):737-40. DMWBRDK RU https://pubmed.ncbi.nlm.nih.gov/9784130 DM8YT7X DI DM8YT7X DM8YT7X DN L-817,818 DM8YT7X MI TTIND6G DM8YT7X MN Somatostatin receptor type 1 (SSTR1) DM8YT7X MT DTT DM8YT7X MA Agonist DM8YT7X RN Rapid identification of subtype-selective agonists of the somatostatin receptor through combinatorial chemistry. Science. 1998 Oct 23;282(5389):737-40. DM8YT7X RU https://pubmed.ncbi.nlm.nih.gov/9784130 DM8YT7X DI DM8YT7X DM8YT7X DN L-817,818 DM8YT7X MI TT2BC4G DM8YT7X MN Somatostatin receptor type 5 (SSTR5) DM8YT7X MT DTT DM8YT7X MA Agonist DM8YT7X RN Rapid identification of subtype-selective agonists of the somatostatin receptor through combinatorial chemistry. Science. 1998 Oct 23;282(5389):737-40. DM8YT7X RU https://pubmed.ncbi.nlm.nih.gov/9784130 DMYJ6QZ DI DMYJ6QZ DMYJ6QZ DN L-826266 DMYJ6QZ MI TTPNGDE DMYJ6QZ MN Prostaglandin E2 receptor EP3 (PTGER3) DMYJ6QZ MT DTT DMYJ6QZ MA Antagonist DMYJ6QZ RN Roles of affinity and lipophilicity in the slow kinetics of prostanoid receptor antagonists on isolated smooth muscle preparations. Br J Pharmacol. 2011 Feb;162(4):863-79. DMYJ6QZ RU https://pubmed.ncbi.nlm.nih.gov/20973775 DMKEDU6 DI DMKEDU6 DMKEDU6 DN L-869298 DMKEDU6 MI TTZ97H5 DMKEDU6 MN Phosphodiesterase 4A (PDE4A) DMKEDU6 MT DTT DMKEDU6 MA Inhibitor DMKEDU6 RN Enantiomer discrimination illustrated by the high resolution crystal structures of type 4 phosphodiesterase. J Med Chem. 2006 Mar 23;49(6):1867-73. DMKEDU6 RU https://pubmed.ncbi.nlm.nih.gov/16539372 DMKEDU6 DI DMKEDU6 DMKEDU6 DN L-869298 DMKEDU6 MI TTVIAT9 DMKEDU6 MN Phosphodiesterase 4B (PDE4B) DMKEDU6 MT DTT DMKEDU6 MA Inhibitor DMKEDU6 RN Enantiomer discrimination illustrated by the high resolution crystal structures of type 4 phosphodiesterase. J Med Chem. 2006 Mar 23;49(6):1867-73. DMKEDU6 RU https://pubmed.ncbi.nlm.nih.gov/16539372 DMKEDU6 DI DMKEDU6 DMKEDU6 DN L-869298 DMKEDU6 MI TTSKMI8 DMKEDU6 MN Phosphodiesterase 4D (PDE4D) DMKEDU6 MT DTT DMKEDU6 MA Inhibitor DMKEDU6 RN Enantiomer discrimination illustrated by the high resolution crystal structures of type 4 phosphodiesterase. J Med Chem. 2006 Mar 23;49(6):1867-73. DMKEDU6 RU https://pubmed.ncbi.nlm.nih.gov/16539372 DMUP516 DI DMUP516 DMUP516 DN L-873724 DMUP516 MI TTF2LRI DMUP516 MN Cathepsin B (CTSB) DMUP516 MT DTT DMUP516 MA Inhibitor DMUP516 RN The identification of potent, selective, and bioavailable cathepsin S inhibitors. Bioorg Med Chem Lett. 2007 Sep 1;17(17):4929-33. DMUP516 RU https://pubmed.ncbi.nlm.nih.gov/17590332 DMUP516 DI DMUP516 DMUP516 DN L-873724 DMUP516 MI TTDZN01 DMUP516 MN Cathepsin K (CTSK) DMUP516 MT DTT DMUP516 MA Inhibitor DMUP516 RN The discovery of odanacatib (MK-0822), a selective inhibitor of cathepsin K. Bioorg Med Chem Lett. 2008 Feb 1;18(3):923-8. DMUP516 RU https://pubmed.ncbi.nlm.nih.gov/18226527 DMUP516 DI DMUP516 DMUP516 DN L-873724 DMUP516 MI TT36ETB DMUP516 MN Cathepsin L (CTSL) DMUP516 MT DTT DMUP516 MA Inhibitor DMUP516 RN The identification of potent, selective, and bioavailable cathepsin S inhibitors. Bioorg Med Chem Lett. 2007 Sep 1;17(17):4929-33. DMUP516 RU https://pubmed.ncbi.nlm.nih.gov/17590332 DMUP516 DI DMUP516 DMUP516 DN L-873724 DMUP516 MI TTUMQVO DMUP516 MN Cathepsin S (CTSS) DMUP516 MT DTT DMUP516 MA Inhibitor DMUP516 RN The identification of potent, selective, and bioavailable cathepsin S inhibitors. Bioorg Med Chem Lett. 2007 Sep 1;17(17):4929-33. DMUP516 RU https://pubmed.ncbi.nlm.nih.gov/17590332 DMMAIQ2 DI DMMAIQ2 DMMAIQ2 DN L-888,291 DMMAIQ2 MI TTNVEIR DMMAIQ2 MN Prostaglandin D2 receptor (PTGDR) DMMAIQ2 MT DTT DMMAIQ2 MA Agonist DMMAIQ2 RN Identification of a potent and selective synthetic agonist at the CRTH2 receptor. Mol Pharmacol. 2005 Jun;67(6):1834-9. DMMAIQ2 RU https://pubmed.ncbi.nlm.nih.gov/15755909 DMMAIQ2 DI DMMAIQ2 DMMAIQ2 DN L-888,291 DMMAIQ2 MI TTQDMX5 DMMAIQ2 MN Prostaglandin D2 receptor 2 (PTGDR2) DMMAIQ2 MT DTT DMMAIQ2 MA Agonist DMMAIQ2 RN Identification of a potent and selective synthetic agonist at the CRTH2 receptor. Mol Pharmacol. 2005 Jun;67(6):1834-9. DMMAIQ2 RU https://pubmed.ncbi.nlm.nih.gov/15755909 DMJCTWO DI DMJCTWO DMJCTWO DN L-888607 DMJCTWO MI TTQDMX5 DMJCTWO MN Prostaglandin D2 receptor 2 (PTGDR2) DMJCTWO MT DTT DMJCTWO MA Inhibitor DMJCTWO RN Indole-3-acetic acid antagonists of the prostaglandin D2 receptor CRTH2. J Med Chem. 2005 Oct 6;48(20):6174-7. DMJCTWO RU https://pubmed.ncbi.nlm.nih.gov/16190744 DMIORW9 DI DMIORW9 DMIORW9 DN L902688 DMIORW9 MI TT79WV3 DMIORW9 MN Prostaglandin E2 receptor EP4 (PTGER4) DMIORW9 MT DTT DMIORW9 MA Agonist DMIORW9 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 343). DMIORW9 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=343 DMYDR2N DI DMYDR2N DMYDR2N DN L-97-1 intravenous DMYDR2N MI TTK25J1 DMYDR2N MN Adenosine A1 receptor (ADORA1) DMYDR2N MT DTT DMYDR2N MA Modulator DMYDR2N RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 18). DMYDR2N RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=18 DMY6K2A DI DMY6K2A DMY6K2A DN LA22-radioimmunoconjugates DMY6K2A MI TTGKNB4 DMY6K2A MN Epidermal growth factor receptor (EGFR) DMY6K2A MT DTT DMY6K2A MA Modulator DMY6K2A RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1797). DMY6K2A RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1797 DMP1V8Y DI DMP1V8Y DMP1V8Y DN LA-480 DMP1V8Y MI TTNDSF4 DMP1V8Y MN Proto-oncogene c-Met (MET) DMP1V8Y MT DTT DMP1V8Y RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1815). DMP1V8Y RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1815 DMJIU3Y DI DMJIU3Y DMJIU3Y DN Lactoferrin DMJIU3Y MI TTM1TDX DMJIU3Y MN Tryptase alpha/beta-1 (Tryptase) DMJIU3Y MT DTT DMJIU3Y MA Inhibitor DMJIU3Y RN Inhibitors of tryptase for the treatment of mast cell-mediated diseases. Curr Pharm Des. 1998 Oct;4(5):381-96. DMJIU3Y RU https://pubmed.ncbi.nlm.nih.gov/10197050 DMZ0O1X DI DMZ0O1X DMZ0O1X DN Lactoquinomycin DMZ0O1X MI TTWTSCV DMZ0O1X MN RAC-alpha serine/threonine-protein kinase (AKT1) DMZ0O1X MT DTT DMZ0O1X MA Inhibitor DMZ0O1X RN The PI3K/Akt pathway as a target in the treatment of hematologic malignancies. Anticancer Agents Med Chem. 2009 Jun;9(5):550-9. DMZ0O1X RU https://pubmed.ncbi.nlm.nih.gov/19519296 DMM0Z6Y DI DMM0Z6Y DMM0Z6Y DN Lactose DMM0Z6Y MI TT50QJ3 DMM0Z6Y MN Influenza Neuraminidase (Influ NA) DMM0Z6Y MT DTT DMM0Z6Y MA Inhibitor DMM0Z6Y RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMM0Z6Y RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMTZ17V DI DMTZ17V DMTZ17V DN Laevulinic Acid DMTZ17V MI TTJHKYD DMTZ17V MN Delta-aminolevulinic acid dehydratase (ALAD) DMTZ17V MT DTT DMTZ17V MA Inhibitor DMTZ17V RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMTZ17V RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMH6XTP DI DMH6XTP DMH6XTP DN L-Ala-L-boroPro DMH6XTP MI TTDIGC1 DMH6XTP MN Dipeptidyl peptidase 4 (DPP-4) DMH6XTP MT DTT DMH6XTP MA Inhibitor DMH6XTP RN Synthesis and characterization of constrained peptidomimetic dipeptidyl peptidase IV inhibitors: amino-lactam boroalanines. J Med Chem. 2007 May 17;50(10):2391-8. DMH6XTP RU https://pubmed.ncbi.nlm.nih.gov/17458948 DMLGK27 DI DMLGK27 DMLGK27 DN LA-N8 DMLGK27 MI TT1290U DMLGK27 MN Coagulation factor VIII (F8) DMLGK27 MT DTT DMLGK27 MA Modulator DMLGK27 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2607). DMLGK27 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2607 DMHN74V DI DMHN74V DMHN74V DN Lanosterol DMHN74V MI DEZNP5G DMHN74V MN Cytochrome P450 51B1 (cyp51) DMHN74V MT DME DMHN74V MA Metabolism DMHN74V RN Function, essentiality, and expression of cytochrome P450 enzymes and their cognate redox partners in Mycobacterium tuberculosis: are they drug targets? Appl Microbiol Biotechnol. 2019 May;103(9):3597-3614. DMHN74V RU https://pubmed.ncbi.nlm.nih.gov/30810776 DMHN74V DI DMHN74V DMHN74V DN Lanosterol DMHN74V MI DEVSF75 DMHN74V MN Cytochrome P450 monooxygenase 51A (cyp51A) DMHN74V MT DME DMHN74V MA Metabolism DMHN74V RN The fungal CYP51s: their functions, structures, related drug resistance, and inhibitors. Front Microbiol. 2019 Apr 24;10:691. DMHN74V RU https://pubmed.ncbi.nlm.nih.gov/31068906 DMHN74V DI DMHN74V DMHN74V DN Lanosterol DMHN74V MI TT7O8ZA DMHN74V MN Lanosterol synthase (LSS) DMHN74V MT DTT DMHN74V MA Inhibitor DMHN74V RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMHN74V RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMPJFGI DI DMPJFGI DMPJFGI DN L-AP4 DMPJFGI MI TTICZ1O DMPJFGI MN Metabotropic glutamate receptor 4 (mGluR4) DMPJFGI MT DTT DMPJFGI MA Agonist DMPJFGI RN Ligand binding to the amino-terminal domain of the mGluR4 subtype of metabotropic glutamate receptor. J Biol Chem. 1999 Apr 9;274(15):10008-13. DMPJFGI RU https://pubmed.ncbi.nlm.nih.gov/10187777 DMPJFGI DI DMPJFGI DMPJFGI DN L-AP4 DMPJFGI MI TTWRP2F DMPJFGI MN Metabotropic glutamate receptor 6 (mGluR6) DMPJFGI MT DTT DMPJFGI MA Agonist DMPJFGI RN Cloning, distribution and functional expression of the human mGlu6 metabotropic glutamate receptor. Neuropharmacology. 1997 Feb;36(2):145-52. DMPJFGI RU https://pubmed.ncbi.nlm.nih.gov/9144651 DMPJFGI DI DMPJFGI DMPJFGI DN L-AP4 DMPJFGI MI TT0I76D DMPJFGI MN Metabotropic glutamate receptor 7 (mGluR7) DMPJFGI MT DTT DMPJFGI MA Agonist DMPJFGI RN Binding of [3H](2S,1'S,2'S)-2-(9-xanthylmethyl)-2-(2'-carboxycyclopropyl) glycine ([3H]LY341495) to cell membranes expressing recombinant human group III metabotropic glutamate receptor subtypes. Naunyn Schmiedebergs Arch Pharmacol. 2000 Dec;362(6):546-54. DMPJFGI RU https://pubmed.ncbi.nlm.nih.gov/11138847 DMPJFGI DI DMPJFGI DMPJFGI DN L-AP4 DMPJFGI MI TT0IFKL DMPJFGI MN Metabotropic glutamate receptor 8 (mGluR8) DMPJFGI MT DTT DMPJFGI MA Agonist DMPJFGI RN Cloning and functional expression of alternative spliced variants of the human metabotropic glutamate receptor 8. Brain Res Mol Brain Res. 1999 Apr 20;67(2):201-10. DMPJFGI RU https://pubmed.ncbi.nlm.nih.gov/10216218 DMSYLIJ DI DMSYLIJ DMSYLIJ DN LARGAZOLE DMSYLIJ MI TT6R7JZ DMSYLIJ MN Histone deacetylase 1 (HDAC1) DMSYLIJ MT DTT DMSYLIJ MA Inhibitor DMSYLIJ RN Synthesis and biological characterization of the histone deacetylase inhibitor largazole and C7- modified analogues. J Med Chem. 2010 Jun 24;53(12):4654-67. DMSYLIJ RU https://pubmed.ncbi.nlm.nih.gov/20491440 DMSYLIJ DI DMSYLIJ DMSYLIJ DN LARGAZOLE DMSYLIJ MI TTTQGH8 DMSYLIJ MN Histone deacetylase 4 (HDAC4) DMSYLIJ MT DTT DMSYLIJ MA Inhibitor DMSYLIJ RN Synthesis and biological characterization of the histone deacetylase inhibitor largazole and C7- modified analogues. J Med Chem. 2010 Jun 24;53(12):4654-67. DMSYLIJ RU https://pubmed.ncbi.nlm.nih.gov/20491440 DMWGPO6 DI DMWGPO6 DMWGPO6 DN L-aspartic acid DMWGPO6 MI TTLD29N DMWGPO6 MN Glutamate receptor ionotropic NMDA 1 (NMDAR1) DMWGPO6 MT DTT DMWGPO6 MA Agonist DMWGPO6 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 455). DMWGPO6 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=455 DMWGPO6 DI DMWGPO6 DMWGPO6 DN L-aspartic acid DMWGPO6 MI TTKJEMQ DMWGPO6 MN Glutamate receptor ionotropic NMDA 2A (NMDAR2A) DMWGPO6 MT DTT DMWGPO6 MA Agonist DMWGPO6 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 456). DMWGPO6 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=456 DMWGPO6 DI DMWGPO6 DMWGPO6 DN L-aspartic acid DMWGPO6 MI TTN9D8E DMWGPO6 MN Glutamate receptor ionotropic NMDA 2B (NMDAR2B) DMWGPO6 MT DTT DMWGPO6 MA Agonist DMWGPO6 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 457). DMWGPO6 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=457 DMWGPO6 DI DMWGPO6 DMWGPO6 DN L-aspartic acid DMWGPO6 MI TT1M8OW DMWGPO6 MN Glutamate receptor ionotropic NMDA 2C (GluN2C) DMWGPO6 MT DTT DMWGPO6 MA Agonist DMWGPO6 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 458). DMWGPO6 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=458 DMWGPO6 DI DMWGPO6 DMWGPO6 DN L-aspartic acid DMWGPO6 MI TT5POTG DMWGPO6 MN Glutamate receptor ionotropic NMDA 2D (GluN2D) DMWGPO6 MT DTT DMWGPO6 MA Agonist DMWGPO6 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 459). DMWGPO6 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=459 DMYNL40 DI DMYNL40 DMYNL40 DN LASSBio-881 DMYNL40 MI TTMI6F5 DMYNL40 MN Transient receptor potential cation channel V1 (TRPV1) DMYNL40 MT DTT DMYNL40 MA Agonist DMYNL40 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 507). DMYNL40 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=507 DMMDZ4B DI DMMDZ4B DMMDZ4B DN LAU-0901 DMMDZ4B MI TTQL5VC DMMDZ4B MN Platelet-activating factor receptor (PTAFR) DMMDZ4B MT DTT DMMDZ4B MA Antagonist DMMDZ4B RN Superior Neuroprotective Efficacy of LAU-0901, a Novel Platelet-Activating Factor Antagonist, in Experimental Stroke. Transl Stroke Res. 2012 Mar;3(1):154-63. DMMDZ4B RU https://pubmed.ncbi.nlm.nih.gov/22408693 DM9C8KQ DI DM9C8KQ DM9C8KQ DN Lauric Acid DM9C8KQ MI TTRFV0W DM9C8KQ MN Bacterial Oxoacyl-[acyl-carrier-protein] synthase II (Bact fabF) DM9C8KQ MT DTT DM9C8KQ MA Inhibitor DM9C8KQ RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DM9C8KQ RU https://pubmed.ncbi.nlm.nih.gov/17139284 DM9C8KQ DI DM9C8KQ DM9C8KQ DN Lauric Acid DM9C8KQ MI DECT13Q DM9C8KQ MN Cytochrome P450 107L2 (cyp107) DM9C8KQ MT DME DM9C8KQ MA Metabolism DM9C8KQ RN The metagenome of Caracolus marginella gut microbiome using culture independent approaches and shotgun sequencing. Data Brief. 2017 Nov 22;16:501-505. DM9C8KQ RU https://pubmed.ncbi.nlm.nih.gov/29270447 DM9C8KQ DI DM9C8KQ DM9C8KQ DN Lauric Acid DM9C8KQ MI TTO8QRU DM9C8KQ MN Group IIA phospholipase A2 (GIIA sPLA2) DM9C8KQ MT DTT DM9C8KQ MA Inhibitor DM9C8KQ RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DM9C8KQ RU https://pubmed.ncbi.nlm.nih.gov/17139284 DM9C8KQ DI DM9C8KQ DM9C8KQ DN Lauric Acid DM9C8KQ MI TT2F3CD DM9C8KQ MN Hepatocyte nuclear factor 4-alpha (HNF4A) DM9C8KQ MT DTT DM9C8KQ MA Inhibitor DM9C8KQ RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DM9C8KQ RU https://pubmed.ncbi.nlm.nih.gov/17139284 DM9C8KQ DI DM9C8KQ DM9C8KQ DN Lauric Acid DM9C8KQ MI TTSZDQU DM9C8KQ MN Lactotransferrin (LTF) DM9C8KQ MT DTT DM9C8KQ MA Inhibitor DM9C8KQ RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DM9C8KQ RU https://pubmed.ncbi.nlm.nih.gov/17139284 DM9C8KQ DI DM9C8KQ DM9C8KQ DN Lauric Acid DM9C8KQ MI TT8S9AV DM9C8KQ MN Lymphocyte antigen 96 (LY96) DM9C8KQ MT DTT DM9C8KQ MA Inhibitor DM9C8KQ RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DM9C8KQ RU https://pubmed.ncbi.nlm.nih.gov/17139284 DM9C8KQ DI DM9C8KQ DM9C8KQ DN Lauric Acid DM9C8KQ MI TTPH97Y DM9C8KQ MN Mycobacterium 3-oxoacyl-[acyl-carrier-protein] synthase 1 (MycB kasA) DM9C8KQ MT DTT DM9C8KQ MA Inhibitor DM9C8KQ RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DM9C8KQ RU https://pubmed.ncbi.nlm.nih.gov/17139284 DM9C8KQ DI DM9C8KQ DM9C8KQ DN Lauric Acid DM9C8KQ MI TTISGCA DM9C8KQ MN Toll-like receptor 4 (TLR4) DM9C8KQ MT DTT DM9C8KQ MA Inhibitor DM9C8KQ RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DM9C8KQ RU https://pubmed.ncbi.nlm.nih.gov/17139284 DM9C8KQ DI DM9C8KQ DM9C8KQ DN Lauric Acid DM9C8KQ MI TTVBE0F DM9C8KQ MN Virus Genome polyprotein (Viru POL) DM9C8KQ MT DTT DM9C8KQ MA Inhibitor DM9C8KQ RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DM9C8KQ RU https://pubmed.ncbi.nlm.nih.gov/17139284 DM3W2OE DI DM3W2OE DM3W2OE DN Lauryl Dimethylamine-N-Oxide DM3W2OE MI TTGP7BY DM3W2OE MN Monoamine oxidase type B (MAO-B) DM3W2OE MT DTT DM3W2OE MA Inhibitor DM3W2OE RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DM3W2OE RU https://pubmed.ncbi.nlm.nih.gov/17139284 DM3W2OE DI DM3W2OE DM3W2OE DN Lauryl Dimethylamine-N-Oxide DM3W2OE MI TT3PQ2Y DM3W2OE MN Plasmodium Dihydroorotate dehydrogenase (Malaria DHOdehase) DM3W2OE MT DTT DM3W2OE MA Inhibitor DM3W2OE RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DM3W2OE RU https://pubmed.ncbi.nlm.nih.gov/17139284 DM3W2OE DI DM3W2OE DM3W2OE DN Lauryl Dimethylamine-N-Oxide DM3W2OE MI TTH0KSX DM3W2OE MN Rhodopsin (RHO) DM3W2OE MT DTT DM3W2OE MA Inhibitor DM3W2OE RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DM3W2OE RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMH3X06 DI DMH3X06 DMH3X06 DN LAVENDUSTIN A DMH3X06 MI TTGKNB4 DMH3X06 MN Epidermal growth factor receptor (EGFR) DMH3X06 MT DTT DMH3X06 MA Inhibitor DMH3X06 RN Novel antiproliferative agents derived from lavendustin A. J Med Chem. 1994 Nov 25;37(24):4079-84. DMH3X06 RU https://pubmed.ncbi.nlm.nih.gov/7990108 DMH3X06 DI DMH3X06 DMH3X06 DN LAVENDUSTIN A DMH3X06 MI TT860QF DMH3X06 MN LCK tyrosine protein kinase (LCK) DMH3X06 MT DTT DMH3X06 MA Inhibitor DMH3X06 RN Non-amine based analogues of lavendustin A as protein-tyrosine kinase inhibitors. J Med Chem. 1993 Oct 1;36(20):3010-4. DMH3X06 RU https://pubmed.ncbi.nlm.nih.gov/8105084 DMOK6IP DI DMOK6IP DMOK6IP DN LAVYPWT DMOK6IP MI TT2THBD DMOK6IP MN P2X purinoceptor 3 (P2RX3) DMOK6IP MT DTT DMOK6IP MA Inhibitor DMOK6IP RN Structure-activity relationship studies of spinorphin as a potent and selective human P2X(3) receptor antagonist. J Med Chem. 2007 Sep 6;50(18):4543-7. DMOK6IP RU https://pubmed.ncbi.nlm.nih.gov/17676725 DM5GNFO DI DM5GNFO DM5GNFO DN LAWSARITOL DM5GNFO MI TT1RS9F DM5GNFO MN Acetylcholinesterase (AChE) DM5GNFO MT DTT DM5GNFO MA Inhibitor DM5GNFO RN Isolation and cholinesterase-inhibition studies of sterols from Haloxylon recurvum. Bioorg Med Chem Lett. 2006 Feb;16(3):573-80. DM5GNFO RU https://pubmed.ncbi.nlm.nih.gov/16274989 DM5GNFO DI DM5GNFO DM5GNFO DN LAWSARITOL DM5GNFO MI TTEB0GD DM5GNFO MN Cholinesterase (BCHE) DM5GNFO MT DTT DM5GNFO MA Inhibitor DM5GNFO RN Isolation and cholinesterase-inhibition studies of sterols from Haloxylon recurvum. Bioorg Med Chem Lett. 2006 Feb;16(3):573-80. DM5GNFO RU https://pubmed.ncbi.nlm.nih.gov/16274989 DM3H9ZY DI DM3H9ZY DM3H9ZY DN LB30812 DM3H9ZY MI TT6L509 DM3H9ZY MN Coagulation factor IIa (F2) DM3H9ZY MT DTT DM3H9ZY MA Inhibitor DM3H9ZY RN Efficacious and orally bioavailable thrombin inhibitors based on a 2,5-thienylamidine at the P1 position: discovery of N-carboxymethyl-d-diphenylalanyl-l-prolyl[(5-amidino-2-thienyl)methyl]amide. J Med Chem. 2003 Aug 14;46(17):3612-22. DM3H9ZY RU https://pubmed.ncbi.nlm.nih.gov/12904065 DM6RH19 DI DM6RH19 DM6RH19 DN LB42908 DM6RH19 MI TT7WZIJ DM6RH19 MN CAAX farnesyltransferase beta (FNTB) DM6RH19 MT DTT DM6RH19 MA Inhibitor DM6RH19 RN A novel class of highly potent, selective, and non-peptidic inhibitor of Ras farnesyltransferase (FTase). Bioorg Med Chem Lett. 2001 Dec 3;11(23):3069-72. DM6RH19 RU https://pubmed.ncbi.nlm.nih.gov/11714612 DMENM1B DI DMENM1B DMENM1B DN L-beta-BA DMENM1B MI TTG2A6F DMENM1B MN Excitatory amino acid transporter 3 (SLC1A1) DMENM1B MT DTT DMENM1B MA Inhibitor DMENM1B RN The substituted aspartate analogue L-beta-threo-benzyl-aspartate preferentially inhibits the neuronal excitatory amino acid transporter EAAT3. Neuropharmacology. 2005 Nov;49(6):850-61. DMENM1B RU https://pubmed.ncbi.nlm.nih.gov/16183084 DMTNQCE DI DMTNQCE DMTNQCE DN L-betagamma-meATP DMTNQCE MI TTCBFJO DMTNQCE MN Insulin receptor (INSR) DMTNQCE MT DTT DMTNQCE MA Inhibitor DMTNQCE RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMTNQCE RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMTNQCE DI DMTNQCE DMTNQCE DN L-betagamma-meATP DMTNQCE MI TTJW7B3 DMTNQCE MN P2X purinoceptor 1 (P2RX1) DMTNQCE MT DTT DMTNQCE MA Agonist DMTNQCE RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 478). DMTNQCE RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=478 DMTNQCE DI DMTNQCE DMTNQCE DN L-betagamma-meATP DMTNQCE MI TTXI3KF DMTNQCE MN Pyridoxal kinase (PDXK) DMTNQCE MT DTT DMTNQCE MA Inhibitor DMTNQCE RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMTNQCE RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMQ2DFN DI DMQ2DFN DMQ2DFN DN LBQ657 DMQ2DFN MI TT5TKPM DMQ2DFN MN Neutral endopeptidase (MME) DMQ2DFN MT DTT DMQ2DFN MA Inhibitor DMQ2DFN RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1611). DMQ2DFN RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1611 DMGWSCI DI DMGWSCI DMGWSCI DN LC34AD3 DMGWSCI MI TT7QNVC DMGWSCI MN Glucose-dependent insulinotropic receptor (GPR119) DMGWSCI MT DTT DMGWSCI MA Agonist DMGWSCI RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 126). DMGWSCI RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=126 DMYONVF DI DMYONVF DMYONVF DN LC-445 DMYONVF MI TTIYVQP DMYONVF MN Polo-like kinase 1 (PLK1) DMYONVF MT DTT DMYONVF MA Inhibitor DMYONVF RN Polo-like kinase (PLK) inhibitors in preclinical and early clinical development in oncology. Oncologist. 2009 Jun;14(6):559-70. DMYONVF RU https://pubmed.ncbi.nlm.nih.gov/19474163 DMPZ8XH DI DMPZ8XH DMPZ8XH DN L-CCG-I DMPZ8XH MI TTVBPDM DMPZ8XH MN Metabotropic glutamate receptor 1 (mGluR1) DMPZ8XH MT DTT DMPZ8XH MA Agonist DMPZ8XH RN Characterization of [(3)H]Quisqualate binding to recombinant rat metabotropic glutamate 1a and 5a receptors and to rat and human brain sections. J Neurochem. 2000 Dec;75(6):2590-601. DMPZ8XH RU https://pubmed.ncbi.nlm.nih.gov/11080213 DMPZ8XH DI DMPZ8XH DMPZ8XH DN L-CCG-I DMPZ8XH MI TTXJ47W DMPZ8XH MN Metabotropic glutamate receptor 2 (mGluR2) DMPZ8XH MT DTT DMPZ8XH MA Agonist DMPZ8XH RN [3H]-LY341495 as a novel antagonist radioligand for group II metabotropic glutamate (mGlu) receptors: characterization of binding to membranes of mGlu receptor subtype expressing cells. Neuropharmacology. 1999 Oct;38(10):1519-29. DMPZ8XH RU https://pubmed.ncbi.nlm.nih.gov/10530814 DMPZ8XH DI DMPZ8XH DMPZ8XH DN L-CCG-I DMPZ8XH MI TT8A9EF DMPZ8XH MN Metabotropic glutamate receptor 3 (mGluR3) DMPZ8XH MT DTT DMPZ8XH MA Agonist DMPZ8XH RN [3H]-LY341495 as a novel antagonist radioligand for group II metabotropic glutamate (mGlu) receptors: characterization of binding to membranes of mGlu receptor subtype expressing cells. Neuropharmacology. 1999 Oct;38(10):1519-29. DMPZ8XH RU https://pubmed.ncbi.nlm.nih.gov/10530814 DMPZ8XH DI DMPZ8XH DMPZ8XH DN L-CCG-I DMPZ8XH MI TTICZ1O DMPZ8XH MN Metabotropic glutamate receptor 4 (mGluR4) DMPZ8XH MT DTT DMPZ8XH MA Agonist DMPZ8XH RN Agonist analysis of 2-(carboxycyclopropyl)glycine isomers for cloned metabotropic glutamate receptor subtypes expressed in Chinese hamster ovary cells. Br J Pharmacol. 1992 Oct;107(2):539-43. DMPZ8XH RU https://pubmed.ncbi.nlm.nih.gov/1330184 DMPZ8XH DI DMPZ8XH DMPZ8XH DN L-CCG-I DMPZ8XH MI TTHS256 DMPZ8XH MN Metabotropic glutamate receptor 5 (mGluR5) DMPZ8XH MT DTT DMPZ8XH MA Agonist DMPZ8XH RN Characterization of [(3)H]Quisqualate binding to recombinant rat metabotropic glutamate 1a and 5a receptors and to rat and human brain sections. J Neurochem. 2000 Dec;75(6):2590-601. DMPZ8XH RU https://pubmed.ncbi.nlm.nih.gov/11080213 DMPZ8XH DI DMPZ8XH DMPZ8XH DN L-CCG-I DMPZ8XH MI TTWRP2F DMPZ8XH MN Metabotropic glutamate receptor 6 (mGluR6) DMPZ8XH MT DTT DMPZ8XH MA Agonist DMPZ8XH RN Comparative effect of L-CCG-I, DCG-IV and gamma-carboxy-L-glutamate on all cloned metabotropic glutamate receptor subtypes. Neuropharmacology. 1998 Aug;37(8):1043-51. DMPZ8XH RU https://pubmed.ncbi.nlm.nih.gov/9833633 DMPZ8XH DI DMPZ8XH DMPZ8XH DN L-CCG-I DMPZ8XH MI TT0I76D DMPZ8XH MN Metabotropic glutamate receptor 7 (mGluR7) DMPZ8XH MT DTT DMPZ8XH MA Agonist DMPZ8XH RN Binding of [3H](2S,1'S,2'S)-2-(9-xanthylmethyl)-2-(2'-carboxycyclopropyl) glycine ([3H]LY341495) to cell membranes expressing recombinant human group III metabotropic glutamate receptor subtypes. Naunyn Schmiedebergs Arch Pharmacol. 2000 Dec;362(6):546-54. DMPZ8XH RU https://pubmed.ncbi.nlm.nih.gov/11138847 DMPZ8XH DI DMPZ8XH DMPZ8XH DN L-CCG-I DMPZ8XH MI TT0IFKL DMPZ8XH MN Metabotropic glutamate receptor 8 (mGluR8) DMPZ8XH MT DTT DMPZ8XH MA Agonist DMPZ8XH RN Cloning and functional expression of alternative spliced variants of the human metabotropic glutamate receptor 8. Brain Res Mol Brain Res. 1999 Apr 20;67(2):201-10. DMPZ8XH RU https://pubmed.ncbi.nlm.nih.gov/10216218 DME4TUQ DI DME4TUQ DME4TUQ DN Lck inhibitor DME4TUQ MI TT860QF DME4TUQ MN LCK tyrosine protein kinase (LCK) DME4TUQ MT DTT DME4TUQ MA Inhibitor DME4TUQ RN Pyrrolo[2,3-d]pyrimidines containing an extended 5-substituent as potent and selective inhibitors of lck II. Bioorg Med Chem Lett. 2000 Oct 2;10(19):2171-4. DME4TUQ RU https://pubmed.ncbi.nlm.nih.gov/11012022 DMD5GO0 DI DMD5GO0 DMD5GO0 DN LD-101 DMD5GO0 MI TTWTSCV DMD5GO0 MN RAC-alpha serine/threonine-protein kinase (AKT1) DMD5GO0 MT DTT DMD5GO0 MA Inhibitor DMD5GO0 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1479). DMD5GO0 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1479 DMC5XQ6 DI DMC5XQ6 DMC5XQ6 DN LD201t1 DMC5XQ6 MI TT2IYXF DMC5XQ6 MN L-selectin (SELL) DMC5XQ6 MT DTT DMC5XQ6 RN Therapeutic applications of aptamers. Expert Opin Investig Drugs. 2008 Jan;17(1):43-60. DMC5XQ6 RU https://pubmed.ncbi.nlm.nih.gov/18095918 DMH7R6L DI DMH7R6L DMH7R6L DN LDC1267 DMH7R6L MI TTIEMFN DMH7R6L MN TYRO3 tyrosine kinase receptor (TYRO3) DMH7R6L MT DTT DMH7R6L MA Inhibitor DMH7R6L RN The E3 ligase Cbl-b and TAM receptors regulate cancer metastasis via natural killer cells. Nature. 2014 Mar 27;507(7493):508-12. DMH7R6L RU https://pubmed.ncbi.nlm.nih.gov/24553136 DMH7R6L DI DMH7R6L DMH7R6L DN LDC1267 DMH7R6L MI TTO7LKR DMH7R6L MN Tyrosine-protein kinase Mer (MERTK) DMH7R6L MT DTT DMH7R6L MA Inhibitor DMH7R6L RN The E3 ligase Cbl-b and TAM receptors regulate cancer metastasis via natural killer cells. Nature. 2014 Mar 27;507(7493):508-12. DMH7R6L RU https://pubmed.ncbi.nlm.nih.gov/24553136 DMH7R6L DI DMH7R6L DMH7R6L DN LDC1267 DMH7R6L MI TTZPY6J DMH7R6L MN Tyrosine-protein kinase UFO (AXL) DMH7R6L MT DTT DMH7R6L MA Inhibitor DMH7R6L RN The E3 ligase Cbl-b and TAM receptors regulate cancer metastasis via natural killer cells. Nature. 2014 Mar 27;507(7493):508-12. DMH7R6L RU https://pubmed.ncbi.nlm.nih.gov/24553136 DM57Z8J DI DM57Z8J DM57Z8J DN LDN-214117 DM57Z8J MI TTJNBQA DM57Z8J MN Activin receptor-like kinase 2 (ALK-2) DM57Z8J MT DTT DM57Z8J MA Inhibitor DM57Z8J RN Structure-activity relationship of 3,5-diaryl-2-aminopyridine ALK2 inhibitors reveals unaltered binding affinity for fibrodysplasia ossificans progressiva causing mutants. J Med Chem. 2014 Oct 9;57(19):7900-15. DM57Z8J RU https://pubmed.ncbi.nlm.nih.gov/25101911 DM57Z8J DI DM57Z8J DM57Z8J DN LDN-214117 DM57Z8J MI TTGYPTC DM57Z8J MN Activin receptor-like kinase-1 (ACVRL1) DM57Z8J MT DTT DM57Z8J MA Inhibitor DM57Z8J RN Structure-activity relationship of 3,5-diaryl-2-aminopyridine ALK2 inhibitors reveals unaltered binding affinity for fibrodysplasia ossificans progressiva causing mutants. J Med Chem. 2014 Oct 9;57(19):7900-15. DM57Z8J RU https://pubmed.ncbi.nlm.nih.gov/25101911 DM57Z8J DI DM57Z8J DM57Z8J DN LDN-214117 DM57Z8J MI TTGKF90 DM57Z8J MN Bone morphogenetic protein receptor (BMPR2) DM57Z8J MT DTT DM57Z8J MA Inhibitor DM57Z8J RN Structure-activity relationship of 3,5-diaryl-2-aminopyridine ALK2 inhibitors reveals unaltered binding affinity for fibrodysplasia ossificans progressiva causing mutants. J Med Chem. 2014 Oct 9;57(19):7900-15. DM57Z8J RU https://pubmed.ncbi.nlm.nih.gov/25101911 DM57Z8J DI DM57Z8J DM57Z8J DN LDN-214117 DM57Z8J MI TTP4520 DM57Z8J MN TGF-beta receptor type I (TGFBR1) DM57Z8J MT DTT DM57Z8J MA Inhibitor DM57Z8J RN Structure-activity relationship of 3,5-diaryl-2-aminopyridine ALK2 inhibitors reveals unaltered binding affinity for fibrodysplasia ossificans progressiva causing mutants. J Med Chem. 2014 Oct 9;57(19):7900-15. DM57Z8J RU https://pubmed.ncbi.nlm.nih.gov/25101911 DMTSLGF DI DMTSLGF DMTSLGF DN LDN-91946 DMTSLGF MI TTX9IFP DMTSLGF MN Ubiquitin thioesterase L1 (UCHL1) DMTSLGF MT DTT DMTSLGF MA Inhibitor DMTSLGF RN Structure-activity relationship, kinetic mechanism, and selectivity for a new class of ubiquitin C-terminal hydrolase-L1 (UCH-L1) inhibitors. Bioorg Med Chem Lett. 2007 Jul 1;17(13):3729-32. DMTSLGF RU https://pubmed.ncbi.nlm.nih.gov/17449248 DMZ21HU DI DMZ21HU DMZ21HU DN LEACHIANONE A DMZ21HU MI TT8JRS7 DMZ21HU MN Beta-secretase (BACE) DMZ21HU MT DTT DMZ21HU MA Inhibitor DMZ21HU RN BACE1 inhibitory effects of lavandulyl flavanones from Sophora flavescens. Bioorg Med Chem. 2008 Jul 15;16(14):6669-74. DMZ21HU RU https://pubmed.ncbi.nlm.nih.gov/18565755 DML0GZ2 DI DML0GZ2 DML0GZ2 DN Lead acetate DML0GZ2 MI TTQ6VF4 DML0GZ2 MN Ferrochelatase (FECH) DML0GZ2 MT DTT DML0GZ2 MA Inhibitor DML0GZ2 RN Ferrochelatase, a novel target for photodynamic therapy of cancer. Oncol Rep. 1999 Nov-Dec;6(6):1439-42. DML0GZ2 RU https://pubmed.ncbi.nlm.nih.gov/10523727 DMZ7OHP DI DMZ7OHP DMZ7OHP DN Lecanindole D DMZ7OHP MI TTUV8G9 DMZ7OHP MN Progesterone receptor (PGR) DMZ7OHP MT DTT DMZ7OHP MA Inhibitor DMZ7OHP RN The lecanindoles, nonsteroidal progestins from the terrestrial fungus Verticillium lecanii 6144. J Nat Prod. 2009 Nov;72(11):1944-8. DMZ7OHP RU https://pubmed.ncbi.nlm.nih.gov/19863083 DM0CEY3 DI DM0CEY3 DM0CEY3 DN Lefaxin DM0CEY3 MI TTCIHJA DM0CEY3 MN Coagulation factor Xa (F10) DM0CEY3 MT DTT DM0CEY3 MA Inhibitor DM0CEY3 RN Novel approaches to the treatment of thrombosis. Trends Pharmacol Sci. 2002 Jan;23(1):25-32. DM0CEY3 RU https://pubmed.ncbi.nlm.nih.gov/11804648 DM5LY1H DI DM5LY1H DM5LY1H DN Leptin DM5LY1H MI TT0HD6V DM5LY1H MN Leptin receptor (LEPR) DM5LY1H MT DTT DM5LY1H MA Modulator DM5LY1H RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1712). DM5LY1H RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1712 DME91CG DI DME91CG DME91CG DN Lerdelimumab DME91CG MI TTY9TWO DME91CG MN Transforming growth factor beta 2 (TGFB2) DME91CG MT DTT DME91CG RN A phase III study of subconjunctival human anti-transforming growth factor beta(2) monoclonal antibody (CAT-152) to prevent scarring after first-time trabeculectomy. Ophthalmology. 2007 Oct;114(10):1822-30. DME91CG RU https://pubmed.ncbi.nlm.nih.gov/17908591 DMDV67S DI DMDV67S DMDV67S DN lergotrile DMDV67S MI TTJS8PY DMDV67S MN 5-HT 6 receptor (HTR6) DMDV67S MT DTT DMDV67S MA Agonist DMDV67S RN Cloning and expression of a novel serotonin receptor with high affinity for tricyclic psychotropic drugs. Mol Pharmacol. 1993 Mar;43(3):320-7. DMDV67S RU https://pubmed.ncbi.nlm.nih.gov/7680751 DMV4OKR DI DMV4OKR DMV4OKR DN L-erythro-3-hydroxyaspartate DMV4OKR MI TTZFUY6 DMV4OKR MN Serine Racemase (SRR) DMV4OKR MT DTT DMV4OKR MA Inhibitor DMV4OKR RN Inhibition of human serine racemase, an emerging target for medicinal chemistry. Curr Drug Targets. 2011 Jun;12(7):1037-55. DMV4OKR RU https://pubmed.ncbi.nlm.nih.gov/21291385 DMV40XH DI DMV40XH DMV40XH DN leualacin DMV40XH MI TT5HONZ DMV40XH MN Calcium channel unspecific (CaC) DMV40XH MT DTT DMV40XH MA Modulator DMV40XH RN Leualacin, a novel calcium blocker from Hapsidospora irregularis. I. Taxonomy, fermentation, isolation, physico-chemical and biological properties. J Antibiot (Tokyo). 1992 Jun;45(6):899-905. DMV40XH RU https://www.ncbi.nlm.nih.gov/pubmed/1500357 DM94JXH DI DM94JXH DM94JXH DN Leucettamidine DM94JXH MI TTN53ZF DM94JXH MN Leukotriene B4 receptor 1 (LTB4R) DM94JXH MT DTT DM94JXH MA Inhibitor DM94JXH RN New leukotriene B4 receptor antagonist: leucettamine A and related imidazole alkaloids from the marine sponge Leucetta microraphis. J Nat Prod. 1993 Jan;56(1):116-21. DM94JXH RU https://pubmed.ncbi.nlm.nih.gov/8383730 DMIZVA6 DI DMIZVA6 DMIZVA6 DN LEUCETTAMINE A DMIZVA6 MI TTN53ZF DMIZVA6 MN Leukotriene B4 receptor 1 (LTB4R) DMIZVA6 MT DTT DMIZVA6 MA Inhibitor DMIZVA6 RN New leukotriene B4 receptor antagonist: leucettamine A and related imidazole alkaloids from the marine sponge Leucetta microraphis. J Nat Prod. 1993 Jan;56(1):116-21. DMIZVA6 RU https://pubmed.ncbi.nlm.nih.gov/8383730 DMFQEWM DI DMFQEWM DMFQEWM DN LEUCETTAMINE B DMFQEWM MI TTRSMW9 DMFQEWM MN Glycogen synthase kinase-3 beta (GSK-3B) DMFQEWM MT DTT DMFQEWM MA Inhibitor DMFQEWM RN Synthesis and preliminary biological evaluation of new derivatives of the marine alkaloid leucettamine B as kinase inhibitors. Eur J Med Chem. 2010 Feb;45(2):805-10. DMFQEWM RU https://pubmed.ncbi.nlm.nih.gov/19879673 DMFQEWM DI DMFQEWM DMFQEWM DN LEUCETTAMINE B DMFQEWM MI TTQWAU1 DMFQEWM MN GSK3A messenger RNA (GSK3A mRNA) DMFQEWM MT DTT DMFQEWM MA Inhibitor DMFQEWM RN Synthesis and preliminary biological evaluation of new derivatives of the marine alkaloid leucettamine B as kinase inhibitors. Eur J Med Chem. 2010 Feb;45(2):805-10. DMFQEWM RU https://pubmed.ncbi.nlm.nih.gov/19879673 DMBYND6 DI DMBYND6 DMBYND6 DN leucettine L41 DMBYND6 MI TTE6YDG DMBYND6 MN CDC-like kinase 1 (CLK1) DMBYND6 MT DTT DMBYND6 MA Inhibitor DMBYND6 RN Leucettines, a class of potent inhibitors of cdc2-like kinases and dual specificity, tyrosine phosphorylation regulated kinases derived from the marine sponge leucettamine B: modulation of alternative pre-RNA splicing. J Med Chem. 2011 Jun 23;54(12):4172-86. DMBYND6 RU https://pubmed.ncbi.nlm.nih.gov/21615147 DMBYND6 DI DMBYND6 DMBYND6 DN leucettine L41 DMBYND6 MI TTQPE1U DMBYND6 MN CDC-like kinase 3 (CLK3) DMBYND6 MT DTT DMBYND6 MA Inhibitor DMBYND6 RN Leucettines, a class of potent inhibitors of cdc2-like kinases and dual specificity, tyrosine phosphorylation regulated kinases derived from the marine sponge leucettamine B: modulation of alternative pre-RNA splicing. J Med Chem. 2011 Jun 23;54(12):4172-86. DMBYND6 RU https://pubmed.ncbi.nlm.nih.gov/21615147 DMBYND6 DI DMBYND6 DMBYND6 DN leucettine L41 DMBYND6 MI TTSBVFO DMBYND6 MN Dual-specificity tyrosine-phosphorylation regulated kinase 1A (DYRK1A) DMBYND6 MT DTT DMBYND6 MA Inhibitor DMBYND6 RN Leucettines, a class of potent inhibitors of cdc2-like kinases and dual specificity, tyrosine phosphorylation regulated kinases derived from the marine sponge leucettamine B: modulation of alternative pre-RNA splicing. J Med Chem. 2011 Jun 23;54(12):4172-86. DMBYND6 RU https://pubmed.ncbi.nlm.nih.gov/21615147 DMBYND6 DI DMBYND6 DMBYND6 DN leucettine L41 DMBYND6 MI TT84OS6 DMBYND6 MN Dual-specificity tyrosine-phosphorylation regulated kinase 2 (DYRK2) DMBYND6 MT DTT DMBYND6 MA Inhibitor DMBYND6 RN Leucettines, a class of potent inhibitors of cdc2-like kinases and dual specificity, tyrosine phosphorylation regulated kinases derived from the marine sponge leucettamine B: modulation of alternative pre-RNA splicing. J Med Chem. 2011 Jun 23;54(12):4172-86. DMBYND6 RU https://pubmed.ncbi.nlm.nih.gov/21615147 DMBYND6 DI DMBYND6 DMBYND6 DN leucettine L41 DMBYND6 MI TTCLIHJ DMBYND6 MN Dual-specificity tyrosine-phosphorylation regulated kinase 4 (DYRK4) DMBYND6 MT DTT DMBYND6 MA Inhibitor DMBYND6 RN Selectivity, cocrystal structures, and neuroprotective properties of leucettines, a family of protein kinase inhibitors derived from the marine sponge alkaloid leucettamine B. J Med Chem. 2012 Nov 8;55(21):9312-30. DMBYND6 RU https://pubmed.ncbi.nlm.nih.gov/22998443 DMBYND6 DI DMBYND6 DMBYND6 DN leucettine L41 DMBYND6 MI TTTN5QW DMBYND6 MN Serine/threonine-protein kinase pim-1 (PIM1) DMBYND6 MT DTT DMBYND6 MA Inhibitor DMBYND6 RN Leucettines, a class of potent inhibitors of cdc2-like kinases and dual specificity, tyrosine phosphorylation regulated kinases derived from the marine sponge leucettamine B: modulation of alternative pre-RNA splicing. J Med Chem. 2011 Jun 23;54(12):4172-86. DMBYND6 RU https://pubmed.ncbi.nlm.nih.gov/21615147 DMT2CZK DI DMT2CZK DMT2CZK DN Leucine-enkephalin DMT2CZK MI TT27RFC DMT2CZK MN Opioid receptor delta (OPRD1) DMT2CZK MT DTT DMT2CZK MA Agonist DMT2CZK RN Inverse agonist action of Leu-enkephalin at delta(2)-opioid receptors mediates spinal antianalgesia. J Pharmacol Exp Ther. 2001 May;297(2):582-9. DMT2CZK RU https://pubmed.ncbi.nlm.nih.gov/11303046 DMT2CZK DI DMT2CZK DMT2CZK DN Leucine-enkephalin DMT2CZK MI TTKWM86 DMT2CZK MN Opioid receptor mu (MOP) DMT2CZK MT DTT DMT2CZK MA Inhibitor DMT2CZK RN Peptides as receptor selectivity modulators of opiate pharmacophores. J Med Chem. 1986 Jul;29(7):1222-5. DMT2CZK RU https://pubmed.ncbi.nlm.nih.gov/2879914 DM6W27F DI DM6W27F DM6W27F DN LEUCOSCEPTOSIDE A DM6W27F MI TTFJ8Q1 DM6W27F MN Protein kinase C alpha (PRKCA) DM6W27F MT DTT DM6W27F MA Inhibitor DM6W27F RN Phenylethanoid glycosides from Digitalis purpurea and Penstemon linarioides with PKCalpha-inhibitory activity. J Nat Prod. 1998 Nov;61(11):1410-2. DM6W27F RU https://pubmed.ncbi.nlm.nih.gov/9834166 DMYX2NJ DI DMYX2NJ DMYX2NJ DN Leukotoxin DMYX2NJ MI TT48WR6 DMYX2NJ MN Integrin alpha-L (ITGAL) DMYX2NJ MT DTT DMYX2NJ MA Modulator DMYX2NJ RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2451). DMYX2NJ RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2451 DMU075F DI DMU075F DMU075F DN Leupeptin DMU075F MI DTUGYRD DMU075F MN P-glycoprotein 1 (ABCB1) DMU075F MT DTP DMU075F MA Substrate DMU075F RN Mammalian drug efflux transporters of the ATP binding cassette (ABC) family in multidrug resistance: A review of the past decade. Cancer Lett. 2016 Jan 1;370(1):153-64. DMU075F RU http://www.ncbi.nlm.nih.gov/pubmed/26499806 DMU075F DI DMU075F DMU075F DN Leupeptin DMU075F MI TTJNPTK DMU075F MN Plasmodium Cysteine protease falcipain (Malaria CPF) DMU075F MT DTT DMU075F MA Inhibitor DMU075F RN Novel molecular targets for antimalarial chemotherapy. Int J Antimicrob Agents. 2007 Jul;30(1):4-10. DMU075F RU https://pubmed.ncbi.nlm.nih.gov/17339102 DMU075F DI DMU075F DMU075F DN Leupeptin DMU075F MI TT7EASG DMU075F MN Plasmodium Cysteine protease falcipain-2 (Malaria CPF2) DMU075F MT DTT DMU075F MA Inhibitor DMU075F RN Novel molecular targets for antimalarial drug development. Chem Biol Drug Des. 2008 Apr;71(4):287-97. DMU075F RU https://pubmed.ncbi.nlm.nih.gov/18298458 DMU075F DI DMU075F DMU075F DN Leupeptin DMU075F MI TTH9VL3 DMU075F MN Plasmodium Plasmepsin 1 (Malaria PLA1) DMU075F MT DTT DMU075F MA Inhibitor DMU075F RN Novel molecular targets for antimalarial chemotherapy. Int J Antimicrob Agents. 2007 Jul;30(1):4-10. DMU075F RU https://pubmed.ncbi.nlm.nih.gov/17339102 DMU075F DI DMU075F DMU075F DN Leupeptin DMU075F MI TTXMNHO DMU075F MN Plasmodium Plasmepsin 2 (Malaria PLA2) DMU075F MT DTT DMU075F MA Inhibitor DMU075F RN Novel molecular targets for antimalarial chemotherapy. Int J Antimicrob Agents. 2007 Jul;30(1):4-10. DMU075F RU https://pubmed.ncbi.nlm.nih.gov/17339102 DMPYSIT DI DMPYSIT DMPYSIT DN levetimide DMPYSIT MI TTOXS3C DMPYSIT MN Muscarinic acetylcholine receptor (CHRM) DMPYSIT MT DTT DMPYSIT MA Antagonist DMPYSIT RN Pharmacological comparison of the cloned human and rat M2 muscarinic receptor genes expressed in the murine fibroblast (B82) cell line. J Pharmacol Exp Ther. 1998 Feb;284(2):500-7. DMPYSIT RU https://pubmed.ncbi.nlm.nih.gov/9454790 DMWDJ0H DI DMWDJ0H DMWDJ0H DN LEVONORDEFRIN DMWDJ0H MI TTNGILX DMWDJ0H MN Adrenergic receptor alpha-1A (ADRA1A) DMWDJ0H MT DTT DMWDJ0H MA Inhibitor DMWDJ0H RN Medetomidine analogs as alpha 2-adrenergic ligands. 2. Design, synthesis, and biological activity of conformationally restricted naphthalene deriva... J Med Chem. 1996 Jul 19;39(15):3001-13. DMWDJ0H RU https://pubmed.ncbi.nlm.nih.gov/8709134 DMWDJ0H DI DMWDJ0H DMWDJ0H DN LEVONORDEFRIN DMWDJ0H MI TTBRKXS DMWDJ0H MN Adrenergic receptor alpha-1B (ADRA1B) DMWDJ0H MT DTT DMWDJ0H MA Inhibitor DMWDJ0H RN Medetomidine analogs as alpha 2-adrenergic ligands. 2. Design, synthesis, and biological activity of conformationally restricted naphthalene deriva... J Med Chem. 1996 Jul 19;39(15):3001-13. DMWDJ0H RU https://pubmed.ncbi.nlm.nih.gov/8709134 DMWDJ0H DI DMWDJ0H DMWDJ0H DN LEVONORDEFRIN DMWDJ0H MI TT34BHT DMWDJ0H MN Adrenergic receptor alpha-1D (ADRA1D) DMWDJ0H MT DTT DMWDJ0H MA Inhibitor DMWDJ0H RN Medetomidine analogs as alpha 2-adrenergic ligands. 2. Design, synthesis, and biological activity of conformationally restricted naphthalene deriva... J Med Chem. 1996 Jul 19;39(15):3001-13. DMWDJ0H RU https://pubmed.ncbi.nlm.nih.gov/8709134 DMV3P89 DI DMV3P89 DMV3P89 DN Levoverbenone DMV3P89 MI DEJVYAZ DMV3P89 MN Cytochrome P450 2A6 (CYP2A6) DMV3P89 MT DME DMV3P89 MA Metabolism DMV3P89 RN Roles of human CYP2A6 and 2B6 and rat CYP2C11 and 2B1 in the 10-hydroxylation of (-)-verbenone by liver microsomes. Drug Metab Dispos. 2003 Aug;31(8):1049-53. DMV3P89 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=12867494 DMV3P89 DI DMV3P89 DMV3P89 DN Levoverbenone DMV3P89 MI DEPKLMQ DMV3P89 MN Cytochrome P450 2B6 (CYP2B6) DMV3P89 MT DME DMV3P89 MA Metabolism DMV3P89 RN Roles of human CYP2A6 and 2B6 and rat CYP2C11 and 2B1 in the 10-hydroxylation of (-)-verbenone by liver microsomes. Drug Metab Dispos. 2003 Aug;31(8):1049-53. DMV3P89 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=12867494 DMOEQTN DI DMOEQTN DMOEQTN DN LF-160335 DMOEQTN MI TTGY8IW DMOEQTN MN B2 bradykinin receptor (BDKRB2) DMOEQTN MT DTT DMOEQTN MA Modulator DMOEQTN RN The ChEMBL database in 2017. Nucleic Acids Res. 2017 Jan 4;45(D1):D945-D954. DMOEQTN RU https://www.ncbi.nlm.nih.gov/pubmed/27899562 DM5G307 DI DM5G307 DM5G307 DN LFA703 DM5G307 MI TT48WR6 DM5G307 MN Integrin alpha-L (ITGAL) DM5G307 MT DTT DM5G307 MA Inhibitor DM5G307 RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DM5G307 RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMTXWCZ DI DMTXWCZ DMTXWCZ DN LFM-A13 DMTXWCZ MI TTGM6VW DMTXWCZ MN Tyrosine-protein kinase BTK (ATK) DMTXWCZ MT DTT DMTXWCZ MA Inhibitor DMTXWCZ RN A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases. Proc Natl Acad Sci U S A. 2007 Dec 18;104(51):20523-8. DMTXWCZ RU https://pubmed.ncbi.nlm.nih.gov/18077363 DMEK4FY DI DMEK4FY DMEK4FY DN LG100754 DMEK4FY MI TTT2SVW DMEK4FY MN PPAR-gamma messenger RNA (PPARG mRNA) DMEK4FY MT DTT DMEK4FY MA Agonist DMEK4FY RN The antidiabetic agent LG100754 sensitizes cells to low concentrations of peroxisome proliferator-activated receptor gamma ligands. J Biol Chem. 2002 Apr 12;277(15):12503-6. DMEK4FY RU https://pubmed.ncbi.nlm.nih.gov/11877384 DMEK4FY DI DMEK4FY DMEK4FY DN LG100754 DMEK4FY MI TT6PEUO DMEK4FY MN Retinoic acid receptor RXR-alpha (RXRA) DMEK4FY MT DTT DMEK4FY MA Antagonist DMEK4FY RN The rexinoid LG100754 is a novel RXR:PPARgamma agonist and decreases glucose levels in vivo. Mol Endocrinol. 2001 Aug;15(8):1360-9. DMEK4FY RU https://pubmed.ncbi.nlm.nih.gov/11463859 DMEK4FY DI DMEK4FY DMEK4FY DN LG100754 DMEK4FY MI TTKLV96 DMEK4FY MN Retinoic acid receptor RXR-beta (RXRB) DMEK4FY MT DTT DMEK4FY MA Antagonist DMEK4FY RN Activation of specific RXR heterodimers by an antagonist of RXR homodimers. Nature. 1996 Oct 3;383(6599):450-3. DMEK4FY RU https://pubmed.ncbi.nlm.nih.gov/8837780 DMEK4FY DI DMEK4FY DMEK4FY DN LG100754 DMEK4FY MI TTH029C DMEK4FY MN Retinoic acid receptor RXR-gamma (RXRG) DMEK4FY MT DTT DMEK4FY MA Antagonist DMEK4FY RN Activation of specific RXR heterodimers by an antagonist of RXR homodimers. Nature. 1996 Oct 3;383(6599):450-3. DMEK4FY RU https://pubmed.ncbi.nlm.nih.gov/8837780 DMG1UOR DI DMG1UOR DMG1UOR DN LG-120838 DMG1UOR MI TTKPW01 DMG1UOR MN Androgen receptor messenger RNA (AR mRNA) DMG1UOR MT DTT DMG1UOR MA Inhibitor DMG1UOR RN 5-Benzylidene 1,2-dihydrochromeno[3,4-f]quinolines, a novel class of nonsteroidal human progesterone receptor agonists. J Med Chem. 1998 Oct 22;41(22):4354-9. DMG1UOR RU https://pubmed.ncbi.nlm.nih.gov/9784110 DMG1UOR DI DMG1UOR DMG1UOR DN LG-120838 DMG1UOR MI TTOZRK6 DMG1UOR MN Glucocorticoid receptor messenger RNA (GCR mRNA) DMG1UOR MT DTT DMG1UOR MA Inhibitor DMG1UOR RN 5-Benzylidene 1,2-dihydrochromeno[3,4-f]quinolines, a novel class of nonsteroidal human progesterone receptor agonists. J Med Chem. 1998 Oct 22;41(22):4354-9. DMG1UOR RU https://pubmed.ncbi.nlm.nih.gov/9784110 DMG1UOR DI DMG1UOR DMG1UOR DN LG-120838 DMG1UOR MI TT26PHO DMG1UOR MN Mineralocorticoid receptor (MR) DMG1UOR MT DTT DMG1UOR MA Inhibitor DMG1UOR RN 5-Benzylidene 1,2-dihydrochromeno[3,4-f]quinolines, a novel class of nonsteroidal human progesterone receptor agonists. J Med Chem. 1998 Oct 22;41(22):4354-9. DMG1UOR RU https://pubmed.ncbi.nlm.nih.gov/9784110 DMMHYQ4 DI DMMHYQ4 DMMHYQ4 DN LG-121071 DMMHYQ4 MI TTKPW01 DMMHYQ4 MN Androgen receptor messenger RNA (AR mRNA) DMMHYQ4 MT DTT DMMHYQ4 MA Inhibitor DMMHYQ4 RN Novel series of potent, nonsteroidal, selective androgen receptor modulators based on 7H-[1,4]oxazino[3,2-g]quinolin-7-ones. J Med Chem. 2007 May 17;50(10):2486-96. DMMHYQ4 RU https://pubmed.ncbi.nlm.nih.gov/17439112 DMO1FCU DI DMO1FCU DMO1FCU DN LG190178 DMO1FCU MI TTK59TV DMO1FCU MN Vitamin D3 receptor (VDR) DMO1FCU MT DTT DMO1FCU MA Agonist DMO1FCU RN Novel nonsecosteroidal vitamin D mimics exert VDR-modulating activities with less calcium mobilization than 1,25-dihydroxyvitamin D3. Chem Biol. 1999 May;6(5):265-75. DMO1FCU RU https://pubmed.ncbi.nlm.nih.gov/10322128 DM1W8Y0 DI DM1W8Y0 DM1W8Y0 DN LG-888 DM1W8Y0 MI TT1290U DM1W8Y0 MN Coagulation factor VIII (F8) DM1W8Y0 MT DTT DM1W8Y0 MA Stimulator DM1W8Y0 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2607). DM1W8Y0 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2607 DMIHDEB DI DMIHDEB DMIHDEB DN LG-889 DMIHDEB MI TT1290U DMIHDEB MN Coagulation factor VIII (F8) DMIHDEB MT DTT DMIHDEB MA Modulator DMIHDEB RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2607). DMIHDEB RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2607 DMKRSZY DI DMKRSZY DMKRSZY DN LGD-2226 DMKRSZY MI TTKPW01 DMKRSZY MN Androgen receptor messenger RNA (AR mRNA) DMKRSZY MT DTT DMKRSZY MA Inhibitor DMKRSZY RN Novel selective androgen receptor modulators: SAR studies on 6-bisalkylamino-2-quinolinones. Bioorg Med Chem Lett. 2007 Mar 15;17(6):1527-31. DMKRSZY RU https://pubmed.ncbi.nlm.nih.gov/17267219 DM67KWM DI DM67KWM DM67KWM DN LGD-5552 DM67KWM MI TTKPW01 DM67KWM MN Androgen receptor messenger RNA (AR mRNA) DM67KWM MT DTT DM67KWM MA Inhibitor DM67KWM RN Antiinflammatory glucocorticoid receptor ligand with reduced side effects exhibits an altered protein-protein interaction profile. Proc Natl Acad Sci U S A. 2007 Dec 4;104(49):19244-9. DM67KWM RU https://pubmed.ncbi.nlm.nih.gov/18032610 DM67KWM DI DM67KWM DM67KWM DN LGD-5552 DM67KWM MI TTOZRK6 DM67KWM MN Glucocorticoid receptor messenger RNA (GCR mRNA) DM67KWM MT DTT DM67KWM MA Inhibitor DM67KWM RN Antiinflammatory glucocorticoid receptor ligand with reduced side effects exhibits an altered protein-protein interaction profile. Proc Natl Acad Sci U S A. 2007 Dec 4;104(49):19244-9. DM67KWM RU https://pubmed.ncbi.nlm.nih.gov/18032610 DM67KWM DI DM67KWM DM67KWM DN LGD-5552 DM67KWM MI TT26PHO DM67KWM MN Mineralocorticoid receptor (MR) DM67KWM MT DTT DM67KWM MA Inhibitor DM67KWM RN Antiinflammatory glucocorticoid receptor ligand with reduced side effects exhibits an altered protein-protein interaction profile. Proc Natl Acad Sci U S A. 2007 Dec 4;104(49):19244-9. DM67KWM RU https://pubmed.ncbi.nlm.nih.gov/18032610 DM67KWM DI DM67KWM DM67KWM DN LGD-5552 DM67KWM MI TTUV8G9 DM67KWM MN Progesterone receptor (PGR) DM67KWM MT DTT DM67KWM MA Inhibitor DM67KWM RN Antiinflammatory glucocorticoid receptor ligand with reduced side effects exhibits an altered protein-protein interaction profile. Proc Natl Acad Sci U S A. 2007 Dec 4;104(49):19244-9. DM67KWM RU https://pubmed.ncbi.nlm.nih.gov/18032610 DMKI70D DI DMKI70D DMKI70D DN LHD-4 DMKI70D MI TT4QPUL DMKI70D MN Antithrombin-III (ATIII) DMKI70D MT DTT DMKI70D MA Modulator DMKI70D RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2632). DMKI70D RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2632 DML83XP DI DML83XP DML83XP DN L-homoarginine DML83XP MI DT96BT4 DML83XP MN Mitochondrial ornithine transporter 3 (SLC25A29) DML83XP MT DTP DML83XP MA Substrate DML83XP RN The human gene SLC25A29, of solute carrier family 25, encodes a mitochondrial transporter of basic amino acids. J Biol Chem. 2014 May 9;289(19):13374-84. DML83XP RU http://www.ncbi.nlm.nih.gov/pubmed/24652292 DML83XP DI DML83XP DML83XP DN L-homoarginine DML83XP MI TTCM4B3 DML83XP MN Nitric-oxide synthase endothelial (NOS3) DML83XP MT DTT DML83XP MA Inhibitor DML83XP RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DML83XP RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMB4ACY DI DMB4ACY DMB4ACY DN LHRH DMB4ACY MI TT8R70G DMB4ACY MN Gonadotropin-releasing hormone receptor (GNRHR) DMB4ACY MT DTT DMB4ACY MA Inhibitor DMB4ACY RN Discovery of a novel, potent, and orally active nonpeptide antagonist of the human luteinizing hormone-releasing hormone (LHRH) receptor. J Med Chem. 1998 Oct 22;41(22):4190-5. DMB4ACY RU https://pubmed.ncbi.nlm.nih.gov/9784092 DMWY0TN DI DMWY0TN DMWY0TN DN LICOAGROCHACONE A DMWY0TN MI TTELIN2 DMWY0TN MN PTPN1 messenger RNA (PTPN1 mRNA) DMWY0TN MT DTT DMWY0TN MA Inhibitor DMWY0TN RN Inhibitory effect of chalcones and their derivatives from Glycyrrhiza inflata on protein tyrosine phosphatase 1B. Bioorg Med Chem Lett. 2009 Sep 1;19(17):5155-7. DMWY0TN RU https://pubmed.ncbi.nlm.nih.gov/19632832 DMY65ZP DI DMY65ZP DMY65ZP DN LICOAGROCHALCONE A DMY65ZP MI TTELIN2 DMY65ZP MN PTPN1 messenger RNA (PTPN1 mRNA) DMY65ZP MT DTT DMY65ZP MA Inhibitor DMY65ZP RN Isoprenylated flavonoids from the stem bark of Erythrina abyssinica. J Nat Prod. 2007 Jun;70(6):1039-42. DMY65ZP RU https://pubmed.ncbi.nlm.nih.gov/17489632 DM2UBQ8 DI DM2UBQ8 DM2UBQ8 DN LIM-5310 DM2UBQ8 MI TTU81IF DM2UBQ8 MN Transporter unspecfic (TP) DM2UBQ8 MT DTT DM2UBQ8 MA Activator DM2UBQ8 RN Limerick BioPharma, Inc. Pharmaceuticals & Healthcare. Deals and Alliances Profile. Limerick BioPharma, Inc. Nov-2014. DM2UBQ8 RU http://store.globaldata.com/company-reports/pharmaceuticals-and-healthcare/limerick-biopharma-inc-pharmaceuticals--healthcare-deals-and-alliances-profile#.Vh39_qToumQ DMGZQ5P DI DMGZQ5P DMGZQ5P DN Linalool DMGZQ5P MI DEQOJDP DMGZQ5P MN Cytochrome P450 111A2 (cyp111) DMGZQ5P MT DME DMGZQ5P MA Metabolism DMGZQ5P RN Patients with primary biliary cirrhosis react against a ubiquitous xenobiotic-metabolizing bacterium. Hepatology. 2003 Nov;38(5):1250-7. DMGZQ5P RU https://pubmed.ncbi.nlm.nih.gov/14578864 DMGZQ5P DI DMGZQ5P DMGZQ5P DN Linalool DMGZQ5P MI TTXDKTO DMGZQ5P MN Long transient receptor potential channel 8 (TRPM8) DMGZQ5P MT DTT DMGZQ5P MA Activator DMGZQ5P RN Characterization of the mouse cold-menthol receptor TRPM8 and vanilloid receptor type-1 VR1 using a fluorometric imaging plate reader (FLIPR) assay. Br J Pharmacol. 2004 Feb;141(4):737-45. DMGZQ5P RU https://pubmed.ncbi.nlm.nih.gov/14757700 DMD3AJH DI DMD3AJH DMD3AJH DN Linear peptide of RES-701-1 DMD3AJH MI TT3ZTGU DMD3AJH MN Endothelin B receptor (EDNRB) DMD3AJH MT DTT DMD3AJH MA Inhibitor DMD3AJH RN RES-701-1/endothelin-1 hybrid peptide having a potent binding activity for type B receptor, Bioorg. Med. Chem. Lett. 7(13):1715-1720 (1997). DMD3AJH RU http://www.sciencedirect.com/science/article/pii/S0960894X97002965 DMDGPY9 DI DMDGPY9 DMDGPY9 DN Linoleic acid DMDGPY9 MI TTHWMFZ DMDGPY9 MN Fatty acid-binding protein 4 (FABP4) DMDGPY9 MT DTT DMDGPY9 MA Inhibitor DMDGPY9 RN Discovery of highly selective inhibitors of human fatty acid binding protein 4 (FABP4) by virtual screening. Bioorg Med Chem Lett. 2010 Jun 15;20(12):3675-9. DMDGPY9 RU https://pubmed.ncbi.nlm.nih.gov/20471252 DMDGPY9 DI DMDGPY9 DMDGPY9 DN Linoleic acid DMDGPY9 MI DEWD860 DMDGPY9 MN Linoleate 10-hydratase (10-LAH) DMDGPY9 MT DME DMDGPY9 MA Metabolism DMDGPY9 RN Characterization of linoleate 10-hydratase of Lactobacillus plantarum and novel antifungal metabolites. Front Microbiol. 2016 Oct 4;7:1561. eCollection 2016. DMDGPY9 RU https://pubmed.ncbi.nlm.nih.gov/27757104 DMDGPY9 DI DMDGPY9 DMDGPY9 DN Linoleic acid DMDGPY9 MI DEQ58KF DMDGPY9 MN Linoleate isomerase (lai) DMDGPY9 MT DME DMDGPY9 MA Metabolism DMDGPY9 RN Cell-associated alpha-amylases of butyrate-producing Firmicute bacteria from the human colon. Microbiology. 2006 Nov;152(Pt 11):3281-3290. DMDGPY9 RU https://pubmed.ncbi.nlm.nih.gov/17074899 DMW9Z7N DI DMW9Z7N DMW9Z7N DN Lipid Fragment DMW9Z7N MI TTUTN1I DMW9Z7N MN Human Deoxyribonucleic acid (hDNA) DMW9Z7N MT DTT DMW9Z7N MA Inhibitor DMW9Z7N RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMW9Z7N RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMUIVCX DI DMUIVCX DMUIVCX DN LIPOCRINE DMUIVCX MI TT1RS9F DMUIVCX MN Acetylcholinesterase (AChE) DMUIVCX MT DTT DMUIVCX MA Inhibitor DMUIVCX RN Toward a rational design of multitarget-directed antioxidants: merging memoquin and lipoic acid molecular frameworks. J Med Chem. 2009 Dec 10;52(23):7883-6. DMUIVCX RU https://pubmed.ncbi.nlm.nih.gov/19813747 DMUIVCX DI DMUIVCX DMUIVCX DN LIPOCRINE DMUIVCX MI TTEB0GD DMUIVCX MN Cholinesterase (BCHE) DMUIVCX MT DTT DMUIVCX MA Inhibitor DMUIVCX RN Toward a rational design of multitarget-directed antioxidants: merging memoquin and lipoic acid molecular frameworks. J Med Chem. 2009 Dec 10;52(23):7883-6. DMUIVCX RU https://pubmed.ncbi.nlm.nih.gov/19813747 DM6YSG3 DI DM6YSG3 DM6YSG3 DN LIQUIRTIGENIN DM6YSG3 MI TTSZLWK DM6YSG3 MN Aromatase (CYP19A1) DM6YSG3 MT DTT DM6YSG3 MA Inhibitor DM6YSG3 RN Screening of herbal constituents for aromatase inhibitory activity. Bioorg Med Chem. 2008 Sep 15;16(18):8466-70. DM6YSG3 RU https://pubmed.ncbi.nlm.nih.gov/18778944 DM6YSG3 DI DM6YSG3 DM6YSG3 DN LIQUIRTIGENIN DM6YSG3 MI TT7RJY8 DM6YSG3 MN Xanthine dehydrogenase/oxidase (XDH) DM6YSG3 MT DTT DM6YSG3 MA Inhibitor DM6YSG3 RN Inhibition of cow's milk xanthine oxidase by flavonoids. J Nat Prod. 1988 Mar-Apr;51(2):345-8. DM6YSG3 RU https://pubmed.ncbi.nlm.nih.gov/3379415 DM54D1G DI DM54D1G DM54D1G DN Lisinopril DM54D1G MI TTGFNPD DM54D1G MN HUMAN angiotensin-converting enzyme (ACE) DM54D1G MT DTT DM54D1G MA Inhibitor DM54D1G RN Coronavirus Disease 2019 (COVID-19) and Cardiovascular Disease: A Viewpoint on the Potential Influence of Angiotensin-Converting Enzyme Inhibitors/Angiotensin Receptor Blockers on Onset and Severity of Severe Acute Respiratory Syndrome Coronavirus 2 Infection. J Am Heart Assoc. 2020 Apr 7;9(7):e016219. DM54D1G RU https://pubmed.ncbi.nlm.nih.gov/32233755 DMQ42KU DI DMQ42KU DMQ42KU DN lisinopril-tryptophan DMQ42KU MI TTL69WB DMQ42KU MN Angiotensin-converting enzyme (ACE) DMQ42KU MT DTT DMQ42KU MA Inhibitor DMQ42KU RN Characterization of domain-selective inhibitor binding in angiotensin-converting enzyme using a novel derivative of lisinopril. Biochem J. 2010 Apr 28;428(1):67-74. DMQ42KU RU https://pubmed.ncbi.nlm.nih.gov/20233165 DM26AB4 DI DM26AB4 DM26AB4 DN L-Iso-Aspartate DM26AB4 MI TTICX3S DM26AB4 MN Bacterial UDP-N-acetylglucosamine carboxyvinyltransferase (Bact murA) DM26AB4 MT DTT DM26AB4 MA Inhibitor DM26AB4 RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DM26AB4 RU https://pubmed.ncbi.nlm.nih.gov/17139284 DM6RKOC DI DM6RKOC DM6RKOC DN L-Isofagomine DM6RKOC MI TT1B5PU DM6RKOC MN Glucosylceramidase (GBA) DM6RKOC MT DTT DM6RKOC MA Inhibitor DM6RKOC RN In vitro inhibition of glycogen-degrading enzymes and glycosidases by six-membered sugar mimics and their evaluation in cell cultures. Bioorg Med Chem. 2008 Aug 1;16(15):7330-6. DM6RKOC RU https://pubmed.ncbi.nlm.nih.gov/18595718 DM4B6H3 DI DM4B6H3 DM4B6H3 DN L-isoleucine DM4B6H3 MI DTBMSWG DM4B6H3 MN L-type amino acid transporter 3 (SLC43A1) DM4B6H3 MT DTP DM4B6H3 MA Substrate DM4B6H3 RN Identification of a novel system L amino acid transporter structurally distinct from heterodimeric amino acid transporters. J Biol Chem. 2003 Oct 31;278(44):43838-45. DM4B6H3 RU http://www.ncbi.nlm.nih.gov/pubmed/12930836 DM4B6H3 DI DM4B6H3 DM4B6H3 DN L-isoleucine DM4B6H3 MI DTK02I1 DM4B6H3 MN L-type amino acid transporter 4 (SLC43A2) DM4B6H3 MT DTP DM4B6H3 MA Substrate DM4B6H3 RN Anticipation of food intake induces phosphorylation switch to regulate basolateral amino acid transporter LAT4 (SLC43A2) function. J Physiol. 2019 Jan;597(2):521-542. DM4B6H3 RU http://www.ncbi.nlm.nih.gov/pubmed/30379325 DMVSAUL DI DMVSAUL DMVSAUL DN L-isoleucyl-L-prolinamide DMVSAUL MI TTQ7R2V DMVSAUL MN Tripeptidyl-peptidase II (TPP2) DMVSAUL MT DTT DMVSAUL MA Inhibitor DMVSAUL RN Inhibitors of tripeptidyl peptidase II. 3. Derivation of butabindide by successive structure optimizations leading to a potential general approach ... J Med Chem. 2005 Nov 17;48(23):7333-42. DMVSAUL RU https://pubmed.ncbi.nlm.nih.gov/16279793 DMHYLQ2 DI DMHYLQ2 DMHYLQ2 DN Lithium chloride DMHYLQ2 MI TTRZQE3 DMHYLQ2 MN Glycogen synthase kinase-3 alpha (GSK-3A) DMHYLQ2 MT DTT DMHYLQ2 MA Inhibitor DMHYLQ2 RN Glycogen synthase kinase 3 beta (GSK-3 beta) as a therapeutic target in neuroAIDS. J Neuroimmune Pharmacol. 2007 Mar;2(1):93-6. DMHYLQ2 RU https://pubmed.ncbi.nlm.nih.gov/18040831 DME76CQ DI DME76CQ DME76CQ DN lithocholylcholine DME76CQ MI TTOXS3C DME76CQ MN Muscarinic acetylcholine receptor (CHRM) DME76CQ MT DTT DME76CQ MA Antagonist DME76CQ RN Lithocholylcholine, a bile acid/acetylcholine hybrid, is a muscarinic receptor antagonist. J Pharmacol Exp Ther. 2002 Oct;303(1):29-35. DME76CQ RU https://pubmed.ncbi.nlm.nih.gov/12235229 DME76CQ DI DME76CQ DME76CQ DN lithocholylcholine DME76CQ MI TTQ13Z5 DME76CQ MN Muscarinic acetylcholine receptor M3 (CHRM3) DME76CQ MT DTT DME76CQ MA Antagonist DME76CQ RN Lithocholylcholine, a bile acid/acetylcholine hybrid, is a muscarinic receptor antagonist. J Pharmacol Exp Ther. 2002 Oct;303(1):29-35. DME76CQ RU https://pubmed.ncbi.nlm.nih.gov/12235229 DMPAKQV DI DMPAKQV DMPAKQV DN Lithospermic acid DMPAKQV MI TTLM12X DMPAKQV MN Matrix metalloproteinase-2 (MMP-2) DMPAKQV MT DTT DMPAKQV MA Inhibitor DMPAKQV RN Matrix metalloproteinase-2 inhibitors from Clinopodium chinense var. parviflorum. J Nat Prod. 2009 Aug;72(8):1379-84. DMPAKQV RU https://pubmed.ncbi.nlm.nih.gov/19711986 DM6J1BY DI DM6J1BY DM6J1BY DN LIVIDOMYCIN A DM6J1BY MI TTQY2EJ DM6J1BY MN TERT messenger RNA (TERT mRNA) DM6J1BY MT DTT DM6J1BY MA Inhibitor DM6J1BY RN Nucleic acid-binding ligands identify new mechanisms to inhibit telomerase. Bioorg Med Chem Lett. 2004 Jul 5;14(13):3467-71. DM6J1BY RU https://pubmed.ncbi.nlm.nih.gov/15177454 DMJ108U DI DMJ108U DMJ108U DN LJP-1207 DMJ108U MI TT7HC21 DMJ108U MN Membrane copper amine oxidase (AOC3) DMJ108U MT DTT DMJ108U MA Inhibitor DMJ108U RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2767). DMJ108U RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2767 DMLVTXM DI DMLVTXM DMLVTXM DN LK 204-545 DMLVTXM MI TTMXGCW DMLVTXM MN Adrenergic receptor beta-3 (ADRB3) DMLVTXM MT DTT DMLVTXM MA Antagonist DMLVTXM RN LK 204-545, a highly selective beta1-adrenoceptor antagonist at human beta-adrenoceptors. Eur J Pharmacol. 1999 Feb 19;367(2-3):431-5. DMLVTXM RU https://pubmed.ncbi.nlm.nih.gov/10079020 DM6RCES DI DM6RCES DM6RCES DN LL-6531 DM6RCES MI TTJ584C DM6RCES MN Peroxisome proliferator-activated receptor alpha (PPARA) DM6RCES MT DTT DM6RCES MA Modulator DM6RCES RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 593). DM6RCES RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=593 DMO1Z5Q DI DMO1Z5Q DMO1Z5Q DN L-lactic acid DMO1Z5Q MI TTVK4ZO DMO1Z5Q MN G protein coupled receptor 81 (HCAR1) DMO1Z5Q MT DTT DMO1Z5Q MA Agonist DMO1Z5Q RN Screening beta-arrestin recruitment for the identification of natural ligands for orphan G-protein-coupled receptors. J Biomol Screen. 2013 Jun;18(5):599-609. DMO1Z5Q RU https://pubmed.ncbi.nlm.nih.gov/23396314 DMO1Z5Q DI DMO1Z5Q DMO1Z5Q DN L-lactic acid DMO1Z5Q MI DEQG7F9 DMO1Z5Q MN Lactate dehydrogenase C (LDHC) DMO1Z5Q MT DME DMO1Z5Q MA Metabolism DMO1Z5Q RN Kinetic characterization of lactate dehydrogenase in normal and malignant human breast tissues. Cancer Cell Int. 2015 Feb 15;15:19. DMO1Z5Q RU https://www.ncbi.nlm.nih.gov/pubmed/?term=25705126 DMQHN7I DI DMQHN7I DMQHN7I DN L-leucine DMQHN7I MI DEP7BTH DMQHN7I MN Leucyl-tRNA synthetase (LARS2) DMQHN7I MT DME DMQHN7I MA Metabolism DMQHN7I RN Expression and characterization of the human mitochondrial leucyl-tRNA synthetase. Biochim Biophys Acta. 2000 Feb 29;1490(3):245-58. DMQHN7I RU https://www.ncbi.nlm.nih.gov/pubmed/?term=10684970 DMQHN7I DI DMQHN7I DMQHN7I DN L-leucine DMQHN7I MI DT48T0N DMQHN7I MN L-type amino acid transporter 1 (SLC7A5) DMQHN7I MT DTP DMQHN7I MA Substrate DMQHN7I RN Bidirectional transport of amino acids regulates mTOR and autophagy. Cell. 2009 Feb 6;136(3):521-34. DMQHN7I RU http://www.ncbi.nlm.nih.gov/pubmed/19203585 DMQHN7I DI DMQHN7I DMQHN7I DN L-leucine DMQHN7I MI DTBMSWG DMQHN7I MN L-type amino acid transporter 3 (SLC43A1) DMQHN7I MT DTP DMQHN7I MA Substrate DMQHN7I RN Identification of a novel system L amino acid transporter structurally distinct from heterodimeric amino acid transporters. J Biol Chem. 2003 Oct 31;278(44):43838-45. DMQHN7I RU http://www.ncbi.nlm.nih.gov/pubmed/12930836 DMQHN7I DI DMQHN7I DMQHN7I DN L-leucine DMQHN7I MI DTK02I1 DMQHN7I MN L-type amino acid transporter 4 (SLC43A2) DMQHN7I MT DTP DMQHN7I MA Substrate DMQHN7I RN Anticipation of food intake induces phosphorylation switch to regulate basolateral amino acid transporter LAT4 (SLC43A2) function. J Physiol. 2019 Jan;597(2):521-542. DMQHN7I RU http://www.ncbi.nlm.nih.gov/pubmed/30379325 DM41MS3 DI DM41MS3 DM41MS3 DN L-leucyl-L-prolinamide DM41MS3 MI TTQ7R2V DM41MS3 MN Tripeptidyl-peptidase II (TPP2) DM41MS3 MT DTT DM41MS3 MA Inhibitor DM41MS3 RN Inhibitors of tripeptidyl peptidase II. 3. Derivation of butabindide by successive structure optimizations leading to a potential general approach ... J Med Chem. 2005 Nov 17;48(23):7333-42. DM41MS3 RU https://pubmed.ncbi.nlm.nih.gov/16279793 DMOD5CK DI DMOD5CK DMOD5CK DN L-lysine DMOD5CK MI TTI1PRE DMOD5CK MN G-protein coupled receptor GPCR33 (GPRC6A) DMOD5CK MT DTT DMOD5CK MA Agonist DMOD5CK RN Deorphanization of GPRC6A: a promiscuous L-alpha-amino acid receptor with preference for basic amino acids. Mol Pharmacol. 2005 Mar;67(3):589-97. DMOD5CK RU https://pubmed.ncbi.nlm.nih.gov/15576628 DMOD5CK DI DMOD5CK DMOD5CK DN L-lysine DMOD5CK MI DT96BT4 DMOD5CK MN Mitochondrial ornithine transporter 3 (SLC25A29) DMOD5CK MT DTP DMOD5CK MA Substrate DMOD5CK RN The human gene SLC25A29, of solute carrier family 25, encodes a mitochondrial transporter of basic amino acids. J Biol Chem. 2014 May 9;289(19):13374-84. DMOD5CK RU http://www.ncbi.nlm.nih.gov/pubmed/24652292 DMOGZLU DI DMOGZLU DMOGZLU DN LLZ16406 DMOGZLU MI TTQBCEJ DMOGZLU MN MAPK/ERK kinase kinase 1 (MAP3K1) DMOGZLU MT DTT DMOGZLU MA Inhibitor DMOGZLU RN Pharmacological inhibitors of MAPK pathways. Trends Pharmacol Sci. 2002 Jan;23(1):40-5. DMOGZLU RU https://pubmed.ncbi.nlm.nih.gov/11804650 DM783BP DI DM783BP DM783BP DN LLZ16407 DM783BP MI TTK1N5G DM783BP MN MAPK/ERK kinase kinase 2 (MAP3K2) DM783BP MT DTT DM783BP MA Inhibitor DM783BP RN Pharmacological inhibitors of MAPK pathways. Trends Pharmacol Sci. 2002 Jan;23(1):40-5. DM783BP RU https://pubmed.ncbi.nlm.nih.gov/11804650 DMWLMTD DI DMWLMTD DMWLMTD DN LM-4108 DMWLMTD MI TTVKILB DMWLMTD MN Prostaglandin G/H synthase 2 (COX-2) DMWLMTD MT DTT DMWLMTD MA Inhibitor DMWLMTD RN Discovery of 3-(4-bromophenyl)-6-nitrobenzo[1.3.2]dithiazolium ylide 1,1-dioxide as a novel dual cyclooxygenase/5-lipoxygenase inhibitor that also ... Bioorg Med Chem. 2010 Jan 15;18(2):597-604. DMWLMTD RU https://pubmed.ncbi.nlm.nih.gov/20056549 DMK12C0 DI DMK12C0 DMK12C0 DN L-mannitol derivative DMK12C0 MI TTH9VL3 DMK12C0 MN Plasmodium Plasmepsin 1 (Malaria PLA1) DMK12C0 MT DTT DMK12C0 MA Inhibitor DMK12C0 RN Synthesis of malarial plasmepsin inhibitors and prediction of binding modes by molecular dynamics simulations. J Med Chem. 2005 Sep 22;48(19):6090-106. DMK12C0 RU https://pubmed.ncbi.nlm.nih.gov/16162010 DME8G1U DI DME8G1U DME8G1U DN L-methionine DME8G1U MI DER6EU8 DME8G1U MN Homoserine-O-transsuccinylase (metAA) DME8G1U MT DME DME8G1U MA Metabolism DME8G1U RN Regulation of the methionine feedback-sensitive enzyme in mutants of Salmonella typhimurium. J Bacteriol. 1972 Jan;109(1):8-11. DME8G1U RU https://pubmed.ncbi.nlm.nih.gov/4550678 DME8G1U DI DME8G1U DME8G1U DN L-methionine DME8G1U MI DEKF1OH DME8G1U MN Methionine adenosyltransferase II beta (MAT2B) DME8G1U MT DME DME8G1U MA Metabolism DME8G1U RN How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DME8G1U RU https://www.ncbi.nlm.nih.gov/pubmed/?term=17139284 DME8G1U DI DME8G1U DME8G1U DN L-methionine DME8G1U MI DEFADPU DME8G1U MN Methionine-R-sulfoxide reductase B1 (MSRB1) DME8G1U MT DME DME8G1U MA Metabolism DME8G1U RN Catalytic advantages provided by selenocysteine in methionine-S-sulfoxide reductases. Biochemistry. 2006 Nov 21;45(46):13697-704. DME8G1U RU https://www.ncbi.nlm.nih.gov/pubmed/?term=17105189 DME8G1U DI DME8G1U DME8G1U DN L-methionine DME8G1U MI DEMQOF7 DME8G1U MN Methionine-R-sulfoxide reductase B2 (MSRB2) DME8G1U MT DME DME8G1U MA Metabolism DME8G1U RN The X-ray structure of the N-terminal domain of PILB from Neisseria meningitidis reveals a thioredoxin-fold. J Mol Biol. 2006 Apr 28;358(2):443-54. DME8G1U RU https://www.ncbi.nlm.nih.gov/pubmed/?term=16530221 DME8G1U DI DME8G1U DME8G1U DN L-methionine DME8G1U MI DE0K52I DME8G1U MN Methionine-tRNA ligase cytoplasmic (MARS) DME8G1U MT DME DME8G1U MA Metabolism DME8G1U RN Mutations in methylenetetrahydrofolate reductase or cystathionine beta-synthase gene, or a high-methionine diet, increase homocysteine thiolactone levels in humans and mice. FASEB J. 2007 Jun;21(8):1707-13. DME8G1U RU https://www.ncbi.nlm.nih.gov/pubmed/?term=17327360 DME8G1U DI DME8G1U DME8G1U DN L-methionine DME8G1U MI DEEH5Y9 DME8G1U MN Methionine-tRNA ligase mitochondrial (MARS2) DME8G1U MT DME DME8G1U MA Metabolism DME8G1U RN How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DME8G1U RU https://www.ncbi.nlm.nih.gov/pubmed/?term=17139284 DME8G1U DI DME8G1U DME8G1U DN L-methionine DME8G1U MI DEU2ZBY DME8G1U MN Peptide methionine sulfoxide reductase (MSRA) DME8G1U MT DME DME8G1U MA Metabolism DME8G1U RN Characterization of the amino acids involved in substrate specificity of methionine sulfoxide reductase A. J Biol Chem. 2007 Jul 13;282(28):20484-91. DME8G1U RU https://www.ncbi.nlm.nih.gov/pubmed/?term=17500063 DME8G1U DI DME8G1U DME8G1U DN L-methionine DME8G1U MI DEQ6NC9 DME8G1U MN S-adenosylmethionine synthase 1 (MAT1A) DME8G1U MT DME DME8G1U MA Metabolism DME8G1U RN Role of methionine adenosyltransferase 2A and S-adenosylmethionine in mitogen-induced growth of human colon cancer cells. Gastroenterology. 2007 Jul;133(1):207-18. DME8G1U RU https://www.ncbi.nlm.nih.gov/pubmed/?term=17631143 DME8G1U DI DME8G1U DME8G1U DN L-methionine DME8G1U MI DE76G8C DME8G1U MN S-adenosylmethionine synthase 2 (MAT2A) DME8G1U MT DME DME8G1U MA Metabolism DME8G1U RN Role of methionine adenosyltransferase 2A and S-adenosylmethionine in mitogen-induced growth of human colon cancer cells. Gastroenterology. 2007 Jul;133(1):207-18. DME8G1U RU https://www.ncbi.nlm.nih.gov/pubmed/?term=17631143 DM8LVQF DI DM8LVQF DM8LVQF DN L-Myo-Inositol-1-Phosphate DM8LVQF MI TTXWL6D DM8LVQF MN Inositol-1(or4)-monophosphatase (IMPA2) DM8LVQF MT DTT DM8LVQF MA Inhibitor DM8LVQF RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DM8LVQF RU https://pubmed.ncbi.nlm.nih.gov/17139284 DME9FAV DI DME9FAV DME9FAV DN L-NIO DME9FAV MI TTZUFI5 DME9FAV MN Nitric-oxide synthase brain (NOS1) DME9FAV MT DTT DME9FAV MA Inhibitor DME9FAV RN Structure-activity relationship of novel and known inhibitors of human dimethylarginine dimethylaminohydrolase-1: alkenyl-amidines as new leads. Bioorg Med Chem. 2008 Dec 15;16(24):10205-9. DME9FAV RU https://pubmed.ncbi.nlm.nih.gov/19013076 DME9FAV DI DME9FAV DME9FAV DN L-NIO DME9FAV MI TTCM4B3 DME9FAV MN Nitric-oxide synthase endothelial (NOS3) DME9FAV MT DTT DME9FAV MA Inhibitor DME9FAV RN DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Nucleic Acids Res. 2011 Jan;39(Database issue):D1035-41. DME9FAV RU https://pubmed.ncbi.nlm.nih.gov/21059682 DME9FAV DI DME9FAV DME9FAV DN L-NIO DME9FAV MI TTF10I9 DME9FAV MN Nitric-oxide synthase inducible (NOS2) DME9FAV MT DTT DME9FAV MA Inhibitor DME9FAV RN Structure-activity relationship of novel and known inhibitors of human dimethylarginine dimethylaminohydrolase-1: alkenyl-amidines as new leads. Bioorg Med Chem. 2008 Dec 15;16(24):10205-9. DME9FAV RU https://pubmed.ncbi.nlm.nih.gov/19013076 DM7V30L DI DM7V30L DM7V30L DN L-norleucyl-L-prolinamide DM7V30L MI TTQ7R2V DM7V30L MN Tripeptidyl-peptidase II (TPP2) DM7V30L MT DTT DM7V30L MA Inhibitor DM7V30L RN Inhibitors of tripeptidyl peptidase II. 3. Derivation of butabindide by successive structure optimizations leading to a potential general approach ... J Med Chem. 2005 Nov 17;48(23):7333-42. DM7V30L RU https://pubmed.ncbi.nlm.nih.gov/16279793 DMIXFGC DI DMIXFGC DMIXFGC DN L-norvalyl-L-prolinamide DMIXFGC MI TTQ7R2V DMIXFGC MN Tripeptidyl-peptidase II (TPP2) DMIXFGC MT DTT DMIXFGC MA Inhibitor DMIXFGC RN Inhibitors of tripeptidyl peptidase II. 3. Derivation of butabindide by successive structure optimizations leading to a potential general approach ... J Med Chem. 2005 Nov 17;48(23):7333-42. DMIXFGC RU https://pubmed.ncbi.nlm.nih.gov/16279793 DM2GBEW DI DM2GBEW DM2GBEW DN Lobatamide A DM2GBEW MI TTTK3BH DM2GBEW MN Vacuolar-type proton ATPase (v-ATPase) DM2GBEW MT DTT DM2GBEW MA Inhibitor DM2GBEW RN Discovery of a novel antitumor benzolactone enamide class that selectively inhibits mammalian vacuolar-type (H+)-atpases. J Pharmacol Exp Ther. 2001 Apr;297(1):114-20. DM2GBEW RU https://pubmed.ncbi.nlm.nih.gov/11259534 DMD91RI DI DMD91RI DMD91RI DN Lobatamide B DMD91RI MI TTTK3BH DMD91RI MN Vacuolar-type proton ATPase (v-ATPase) DMD91RI MT DTT DMD91RI MA Inhibitor DMD91RI RN Discovery of a novel antitumor benzolactone enamide class that selectively inhibits mammalian vacuolar-type (H+)-atpases. J Pharmacol Exp Ther. 2001 Apr;297(1):114-20. DMD91RI RU https://pubmed.ncbi.nlm.nih.gov/11259534 DMFIDJS DI DMFIDJS DMFIDJS DN Lobatamide C DMFIDJS MI TTTK3BH DMFIDJS MN Vacuolar-type proton ATPase (v-ATPase) DMFIDJS MT DTT DMFIDJS MA Inhibitor DMFIDJS RN Discovery of a novel antitumor benzolactone enamide class that selectively inhibits mammalian vacuolar-type (H+)-atpases. J Pharmacol Exp Ther. 2001 Apr;297(1):114-20. DMFIDJS RU https://pubmed.ncbi.nlm.nih.gov/11259534 DMG706J DI DMG706J DMG706J DN Lobatamide D DMG706J MI TTTK3BH DMG706J MN Vacuolar-type proton ATPase (v-ATPase) DMG706J MT DTT DMG706J MA Inhibitor DMG706J RN Discovery of a novel antitumor benzolactone enamide class that selectively inhibits mammalian vacuolar-type (H+)-atpases. J Pharmacol Exp Ther. 2001 Apr;297(1):114-20. DMG706J RU https://pubmed.ncbi.nlm.nih.gov/11259534 DM6BWGQ DI DM6BWGQ DM6BWGQ DN Lobatamide F DM6BWGQ MI TTTK3BH DM6BWGQ MN Vacuolar-type proton ATPase (v-ATPase) DM6BWGQ MT DTT DM6BWGQ MA Inhibitor DM6BWGQ RN Discovery of a novel antitumor benzolactone enamide class that selectively inhibits mammalian vacuolar-type (H+)-atpases. J Pharmacol Exp Ther. 2001 Apr;297(1):114-20. DM6BWGQ RU https://pubmed.ncbi.nlm.nih.gov/11259534 DMR2WQE DI DMR2WQE DMR2WQE DN LOFENTANIL DMR2WQE MI TT27RFC DMR2WQE MN Opioid receptor delta (OPRD1) DMR2WQE MT DTT DMR2WQE MA Inhibitor DMR2WQE RN Potential affinity labels for the opiate receptor based on fentanyl and related compounds. J Med Chem. 1982 Aug;25(8):913-9. DMR2WQE RU https://pubmed.ncbi.nlm.nih.gov/6288945 DMR2WQE DI DMR2WQE DMR2WQE DN LOFENTANIL DMR2WQE MI TTQW87Y DMR2WQE MN Opioid receptor kappa (OPRK1) DMR2WQE MT DTT DMR2WQE MA Inhibitor DMR2WQE RN Potential affinity labels for the opiate receptor based on fentanyl and related compounds. J Med Chem. 1982 Aug;25(8):913-9. DMR2WQE RU https://pubmed.ncbi.nlm.nih.gov/6288945 DMR2WQE DI DMR2WQE DMR2WQE DN LOFENTANIL DMR2WQE MI TTKWM86 DMR2WQE MN Opioid receptor mu (MOP) DMR2WQE MT DTT DMR2WQE MA Inhibitor DMR2WQE RN Potential affinity labels for the opiate receptor based on fentanyl and related compounds. J Med Chem. 1982 Aug;25(8):913-9. DMR2WQE RU https://pubmed.ncbi.nlm.nih.gov/6288945 DMWFAPJ DI DMWFAPJ DMWFAPJ DN LONCHOCARPUSONE DMWFAPJ MI TTUMGNO DMWFAPJ MN Ornithine decarboxylase (ODC1) DMWFAPJ MT DTT DMWFAPJ MA Inhibitor DMWFAPJ RN New bioactive flavonoids and stilbenes in cub resin insecticide. J Nat Prod. 1999 Feb;62(2):205-10. DMWFAPJ RU https://pubmed.ncbi.nlm.nih.gov/10075742 DMAH0RZ DI DMAH0RZ DMAH0RZ DN Long-acting Factor VII conjugate DMAH0RZ MI TTF0EGX DMAH0RZ MN Coagulation factor VII (F7) DMAH0RZ MT DTT DMAH0RZ MA Modulator DMAH0RZ RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2363). DMAH0RZ RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2363 DMZUSJD DI DMZUSJD DMZUSJD DN Long-acting factor VIII DMZUSJD MI TT1290U DMZUSJD MN Coagulation factor VIII (F8) DMZUSJD MT DTT DMZUSJD MA Modulator DMZUSJD RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2607). DMZUSJD RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2607 DMD32IN DI DMD32IN DMD32IN DN Long-acting FSH conjugate DMD32IN MI TTZFDBT DMD32IN MN Follicle-stimulating hormone receptor (FSHR) DMD32IN MT DTT DMD32IN MA Modulator DMD32IN RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 253). DMD32IN RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=253 DMH106Y DI DMH106Y DMH106Y DN LONGANINE DMH106Y MI TT27RFC DMH106Y MN Opioid receptor delta (OPRD1) DMH106Y MT DTT DMH106Y MA Inhibitor DMH106Y RN Hasubanan alkaloids with delta-opioid binding affinity from the aerial parts of Stephania japonica. J Nat Prod. 2010 May 28;73(5):988-91. DMH106Y RU https://pubmed.ncbi.nlm.nih.gov/20426456 DM5OHVN DI DM5OHVN DM5OHVN DN Lophocladine a DM5OHVN MI TT27RFC DM5OHVN MN Opioid receptor delta (OPRD1) DM5OHVN MT DTT DM5OHVN MA Inhibitor DM5OHVN RN Lophocladines, bioactive alkaloids from the red alga Lophocladia sp. J Nat Prod. 2006 Apr;69(4):640-4. DM5OHVN RU https://pubmed.ncbi.nlm.nih.gov/16643042 DMASPV9 DI DMASPV9 DMASPV9 DN Lopinavir + ritonavir + interferon beta DMASPV9 MI TTWOH4Q DMASPV9 MN MERS-CoV 3C-like proteinase (3CLpro) DMASPV9 MT DTT DMASPV9 MA Inhibitor DMASPV9 RN Coronavirus puts drug repurposing on the fast track. Nat Biotechnol. 2020 Apr;38(4):379-381. DMASPV9 RU https://pubmed.ncbi.nlm.nih.gov/32205870 DM71BIC DI DM71BIC DM71BIC DN LOR-220 DM71BIC MI TTHBTOP DM71BIC MN PI3-kinase gamma (PIK3CG) DM71BIC MT DTT DM71BIC MA Inhibitor DM71BIC RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2155). DM71BIC RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2155 DM0ECUK DI DM0ECUK DM0ECUK DN LORNEIC ACID A DM0ECUK MI TTJ0IQB DM0ECUK MN Phosphodiesterase 5A (PDE5A) DM0ECUK MT DTT DM0ECUK MA Inhibitor DM0ECUK RN Lorneic acids, trialkyl-substituted aromatic acids from a marine-derived actinomycete. J Nat Prod. 2009 Nov;72(11):2046-8. DM0ECUK RU https://pubmed.ncbi.nlm.nih.gov/19856955 DMHKGCM DI DMHKGCM DMHKGCM DN L-Ornithine DMHKGCM MI DTWY9RT DMHKGCM MN Cationic amino acid transporter 2 (SLC7A2) DMHKGCM MT DTP DMHKGCM MA Substrate DMHKGCM RN Genetic basis for plasma amino acid concentrations based on absolute quantification: a genome-wide association study in the Japanese population. Eur J Hum Genet. 2019 Apr;27(4):621-630. DMHKGCM RU http://www.ncbi.nlm.nih.gov/pubmed/30659259 DMHKGCM DI DMHKGCM DMHKGCM DN L-Ornithine DMHKGCM MI TTI1PRE DMHKGCM MN G-protein coupled receptor GPCR33 (GPRC6A) DMHKGCM MT DTT DMHKGCM MA Agonist DMHKGCM RN Deorphanization of GPRC6A: a promiscuous L-alpha-amino acid receptor with preference for basic amino acids. Mol Pharmacol. 2005 Mar;67(3):589-97. DMHKGCM RU https://pubmed.ncbi.nlm.nih.gov/15576628 DMK5J9M DI DMK5J9M DMK5J9M DN Lorpiprazole DMK5J9M MI DECB0K3 DMK5J9M MN Cytochrome P450 2D6 (CYP2D6) DMK5J9M MT DME DMK5J9M MA Metabolism DMK5J9M RN [Trazodon--the antidepressant: mechanism of action and its position in the treatment of depression]. Psychiatr Pol. 2011 Jul-Aug;45(4):611-25. DMK5J9M RU https://www.ncbi.nlm.nih.gov/pubmed/?term=22232986 DMWTJ3E DI DMWTJ3E DMWTJ3E DN LP-0067 DMWTJ3E MI TTBID49 DMWTJ3E MN C-X-C chemokine receptor type 4 (CXCR4) DMWTJ3E MT DTT DMWTJ3E MA Antagonist DMWTJ3E RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 71). DMWTJ3E RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=71 DM8ZR17 DI DM8ZR17 DM8ZR17 DN LP-12 DM8ZR17 MI TTSQIFT DM8ZR17 MN 5-HT 1A receptor (HTR1A) DM8ZR17 MT DTT DM8ZR17 MA Agonist DM8ZR17 RN Structure-activity relationship study on N-(1,2,3,4-tetrahydronaphthalen-1-yl)-4-aryl-1-piperazinehexanamides, a class of 5-HT7 receptor agents. 2. J Med Chem. 2007 Aug 23;50(17):4214-21. DM8ZR17 RU https://pubmed.ncbi.nlm.nih.gov/17649988 DM8ZR17 DI DM8ZR17 DM8ZR17 DN LP-12 DM8ZR17 MI TTJQOD7 DM8ZR17 MN 5-HT 2A receptor (HTR2A) DM8ZR17 MT DTT DM8ZR17 MA Agonist DM8ZR17 RN Structure-activity relationship study on N-(1,2,3,4-tetrahydronaphthalen-1-yl)-4-aryl-1-piperazinehexanamides, a class of 5-HT7 receptor agents. 2. J Med Chem. 2007 Aug 23;50(17):4214-21. DM8ZR17 RU https://pubmed.ncbi.nlm.nih.gov/17649988 DM8ZR17 DI DM8ZR17 DM8ZR17 DN LP-12 DM8ZR17 MI TTO9X1H DM8ZR17 MN 5-HT 7 receptor (HTR7) DM8ZR17 MT DTT DM8ZR17 MA Agonist DM8ZR17 RN Structure-activity relationship study on N-(1,2,3,4-tetrahydronaphthalen-1-yl)-4-aryl-1-piperazinehexanamides, a class of 5-HT7 receptor agents. 2. J Med Chem. 2007 Aug 23;50(17):4214-21. DM8ZR17 RU https://pubmed.ncbi.nlm.nih.gov/17649988 DM8ZR17 DI DM8ZR17 DM8ZR17 DN LP-12 DM8ZR17 MI TTEX248 DM8ZR17 MN Dopamine D2 receptor (D2R) DM8ZR17 MT DTT DM8ZR17 MA Agonist DM8ZR17 RN Structure-activity relationship study on N-(1,2,3,4-tetrahydronaphthalen-1-yl)-4-aryl-1-piperazinehexanamides, a class of 5-HT7 receptor agents. 2. J Med Chem. 2007 Aug 23;50(17):4214-21. DM8ZR17 RU https://pubmed.ncbi.nlm.nih.gov/17649988 DMKDGLA DI DMKDGLA DMKDGLA DN LP-211 DMKDGLA MI TTSQIFT DMKDGLA MN 5-HT 1A receptor (HTR1A) DMKDGLA MT DTT DMKDGLA MA Agonist DMKDGLA RN Structural modifications of N-(1,2,3,4-tetrahydronaphthalen-1-yl)-4-aryl-1-piperazinehexanamides: influence on lipophilicity and 5-HT7 receptor act... J Med Chem. 2008 Sep 25;51(18):5813-22. DMKDGLA RU https://pubmed.ncbi.nlm.nih.gov/18800769 DMKDGLA DI DMKDGLA DMKDGLA DN LP-211 DMKDGLA MI TTO9X1H DMKDGLA MN 5-HT 7 receptor (HTR7) DMKDGLA MT DTT DMKDGLA MA Agonist DMKDGLA RN Structural modifications of N-(1,2,3,4-tetrahydronaphthalen-1-yl)-4-aryl-1-piperazinehexanamides: influence on lipophilicity and 5-HT7 receptor act... J Med Chem. 2008 Sep 25;51(18):5813-22. DMKDGLA RU https://pubmed.ncbi.nlm.nih.gov/18800769 DMKDGLA DI DMKDGLA DMKDGLA DN LP-211 DMKDGLA MI TTEX248 DMKDGLA MN Dopamine D2 receptor (D2R) DMKDGLA MT DTT DMKDGLA MA Agonist DMKDGLA RN Structural modifications of N-(1,2,3,4-tetrahydronaphthalen-1-yl)-4-aryl-1-piperazinehexanamides: influence on lipophilicity and 5-HT7 receptor act... J Med Chem. 2008 Sep 25;51(18):5813-22. DMKDGLA RU https://pubmed.ncbi.nlm.nih.gov/18800769 DMIWMZY DI DMIWMZY DMIWMZY DN LP-403812 DMIWMZY MI TT9LGO5 DMIWMZY MN Sodium-dependent proline transporter (SLC6A7) DMIWMZY MT DTT DMIWMZY MA Inhibitor DMIWMZY RN Discovery and characterization of potent small molecule inhibitors of the high affinity proline transporter. Neurosci Lett. 2009 Feb 27;451(3):212-6. DMIWMZY RU https://pubmed.ncbi.nlm.nih.gov/19159658 DM0C3SF DI DM0C3SF DM0C3SF DN LP-44 DM0C3SF MI TTSQIFT DM0C3SF MN 5-HT 1A receptor (HTR1A) DM0C3SF MT DTT DM0C3SF MA Agonist DM0C3SF RN Structure-activity relationship study on N-(1,2,3,4-tetrahydronaphthalen-1-yl)-4-aryl-1-piperazinehexanamides, a class of 5-HT7 receptor agents. 2. J Med Chem. 2007 Aug 23;50(17):4214-21. DM0C3SF RU https://pubmed.ncbi.nlm.nih.gov/17649988 DM0C3SF DI DM0C3SF DM0C3SF DN LP-44 DM0C3SF MI TTJQOD7 DM0C3SF MN 5-HT 2A receptor (HTR2A) DM0C3SF MT DTT DM0C3SF MA Agonist DM0C3SF RN Structure-activity relationship study on N-(1,2,3,4-tetrahydronaphthalen-1-yl)-4-aryl-1-piperazinehexanamides, a class of 5-HT7 receptor agents. 2. J Med Chem. 2007 Aug 23;50(17):4214-21. DM0C3SF RU https://pubmed.ncbi.nlm.nih.gov/17649988 DM0C3SF DI DM0C3SF DM0C3SF DN LP-44 DM0C3SF MI TTO9X1H DM0C3SF MN 5-HT 7 receptor (HTR7) DM0C3SF MT DTT DM0C3SF MA Agonist DM0C3SF RN Structure-activity relationship study on N-(1,2,3,4-tetrahydronaphthalen-1-yl)-4-aryl-1-piperazinehexanamides, a class of 5-HT7 receptor agents. 2. J Med Chem. 2007 Aug 23;50(17):4214-21. DM0C3SF RU https://pubmed.ncbi.nlm.nih.gov/17649988 DM0C3SF DI DM0C3SF DM0C3SF DN LP-44 DM0C3SF MI TTEX248 DM0C3SF MN Dopamine D2 receptor (D2R) DM0C3SF MT DTT DM0C3SF MA Agonist DM0C3SF RN Structure-activity relationship study on N-(1,2,3,4-tetrahydronaphthalen-1-yl)-4-aryl-1-piperazinehexanamides, a class of 5-HT7 receptor agents. 2. J Med Chem. 2007 Aug 23;50(17):4214-21. DM0C3SF RU https://pubmed.ncbi.nlm.nih.gov/17649988 DMGMO3Q DI DMGMO3Q DMGMO3Q DN LP-661438 DMGMO3Q MI TTJOCE4 DMGMO3Q MN Deoxycytidine kinase (DCK) DMGMO3Q MT DTT DMGMO3Q MA Modulator DMGMO3Q RN 236th ACS National Meeting DMGMO3Q RU http://www.amriglobal.com/img/document_files/TR_aug08a.pdf DMTZYQ3 DI DMTZYQ3 DMTZYQ3 DN LP99 DMTZYQ3 MI TT07ZS1 DMTZYQ3 MN Bromodomain-containing protein 7 (BRD7) DMTZYQ3 MT DTT DMTZYQ3 MA Inhibitor DMTZYQ3 RN LP99: Discovery and Synthesis of the First Selective BRD7/9 Bromodomain Inhibitor. Angew Chem Int Ed Engl. 2015 May 18;54(21):6217-21. DMTZYQ3 RU https://pubmed.ncbi.nlm.nih.gov/25864491 DMTZYQ3 DI DMTZYQ3 DMTZYQ3 DN LP99 DMTZYQ3 MI TTR7L5Y DMTZYQ3 MN Bromodomain-containing protein 9 (BRD9) DMTZYQ3 MT DTT DMTZYQ3 MA Inhibitor DMTZYQ3 RN LP99: Discovery and Synthesis of the First Selective BRD7/9 Bromodomain Inhibitor. Angew Chem Int Ed Engl. 2015 May 18;54(21):6217-21. DMTZYQ3 RU https://pubmed.ncbi.nlm.nih.gov/25864491 DMI5XR1 DI DMI5XR1 DMI5XR1 DN LPA DMI5XR1 MI TTO897C DMI5XR1 MN G protein coupled receptor 87 (GPR87) DMI5XR1 MT DTT DMI5XR1 MA Agonist DMI5XR1 RN Identification of the orphan GPCR, P2Y(10) receptor as the sphingosine-1-phosphate and lysophosphatidic acid receptor. Biochem Biophys Res Commun. 2008 Jul 11;371(4):707-12. DMI5XR1 RU https://pubmed.ncbi.nlm.nih.gov/18466763 DMI5XR1 DI DMI5XR1 DMI5XR1 DN LPA DMI5XR1 MI TTE2YJR DMI5XR1 MN Lysophosphatidate-3 receptor (LPAR3) DMI5XR1 MT DTT DMI5XR1 MA Agonist DMI5XR1 RN Molecular cloning and characterization of a novel human G-protein-coupled receptor, EDG7, for lysophosphatidic acid. J Biol Chem. 1999 Sep 24;274(39):27776-85. DMI5XR1 RU https://pubmed.ncbi.nlm.nih.gov/10488122 DMI5XR1 DI DMI5XR1 DMI5XR1 DN LPA DMI5XR1 MI TTQ6S1K DMI5XR1 MN Lysophosphatidic acid receptor 1 (LPAR1) DMI5XR1 MT DTT DMI5XR1 MA Agonist DMI5XR1 RN Diversity of lysophosphatidic acid receptor-mediated intracellular calcium signaling in early cortical neurogenesis. J Neurosci. 2010 May 26;30(21):7300-9. DMI5XR1 RU https://pubmed.ncbi.nlm.nih.gov/20505096 DMI5XR1 DI DMI5XR1 DMI5XR1 DN LPA DMI5XR1 MI TTB7Y8I DMI5XR1 MN Lysophosphatidic acid receptor 2 (LPAR2) DMI5XR1 MT DTT DMI5XR1 MA Agonist DMI5XR1 RN Synthesis and biological evaluation of phosphonic and thiophosphoric acid derivatives of lysophosphatidic acid. Bioorg Med Chem Lett. 2004 Jul 5;14(13):3473-6. DMI5XR1 RU https://pubmed.ncbi.nlm.nih.gov/15177455 DMI5XR1 DI DMI5XR1 DMI5XR1 DN LPA DMI5XR1 MI TT7ZMY4 DMI5XR1 MN Lysophosphatidic acid receptor 4 (LPAR4) DMI5XR1 MT DTT DMI5XR1 MA Agonist DMI5XR1 RN Identification of p2y9/GPR23 as a novel G protein-coupled receptor for lysophosphatidic acid, structurally distant from the Edg family. J Biol Chem. 2003 Jul 11;278(28):25600-6. DMI5XR1 RU https://pubmed.ncbi.nlm.nih.gov/12724320 DMI5XR1 DI DMI5XR1 DMI5XR1 DN LPA DMI5XR1 MI TTABCJ6 DMI5XR1 MN Lysophosphatidic acid receptor 5 (LPAR5) DMI5XR1 MT DTT DMI5XR1 MA Agonist DMI5XR1 RN Screening beta-arrestin recruitment for the identification of natural ligands for orphan G-protein-coupled receptors. J Biomol Screen. 2013 Jun;18(5):599-609. DMI5XR1 RU https://pubmed.ncbi.nlm.nih.gov/23396314 DMI5XR1 DI DMI5XR1 DMI5XR1 DN LPA DMI5XR1 MI TTZDAGB DMI5XR1 MN Lysophosphatidic acid receptor 6 (LPAR6) DMI5XR1 MT DTT DMI5XR1 MA Agonist DMI5XR1 RN G protein-coupled receptor P2Y5 and its ligand LPA are involved in maintenance of human hair growth. Nat Genet. 2008 Mar;40(3):329-34. DMI5XR1 RU https://pubmed.ncbi.nlm.nih.gov/18297070 DMI5XR1 DI DMI5XR1 DMI5XR1 DN LPA DMI5XR1 MI TTMFOU6 DMI5XR1 MN P2Y purinoceptor 10 (P2RY10) DMI5XR1 MT DTT DMI5XR1 MA Agonist DMI5XR1 RN Identification of the orphan GPCR, P2Y(10) receptor as the sphingosine-1-phosphate and lysophosphatidic acid receptor. Biochem Biophys Res Commun. 2008 Jul 11;371(4):707-12. DMI5XR1 RU https://pubmed.ncbi.nlm.nih.gov/18466763 DMI5XR1 DI DMI5XR1 DMI5XR1 DN LPA DMI5XR1 MI TT9JZCK DMI5XR1 MN Sphingosine-1-phosphate receptor 1 (S1PR1) DMI5XR1 MT DTT DMI5XR1 MA Agonist DMI5XR1 RN Lysophosphatidic acid stimulates the G-protein-coupled receptor EDG-1 as a low affinity agonist. J Biol Chem. 1998 Aug 21;273(34):22105-12. DMI5XR1 RU https://pubmed.ncbi.nlm.nih.gov/9705355 DM1JGDM DI DM1JGDM DM1JGDM DN Lpc-Ether DM1JGDM MI TT9V5JH DM1JGDM MN Phospholipase A2 (PLA2G1B) DM1JGDM MT DTT DM1JGDM MA Inhibitor DM1JGDM RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DM1JGDM RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMY1807 DI DMY1807 DMY1807 DN LRHYLNLLTRQRY-NH2 DMY1807 MI TTRK9JT DMY1807 MN Neuropeptide Y receptor type 1 (NPY1R) DMY1807 MT DTT DMY1807 MA Inhibitor DMY1807 RN A long-acting selective neuropeptide Y2 receptor PEGylated peptide agonist reduces food intake in mice. Bioorg Med Chem Lett. 2007 Apr 1;17(7):1916-9. DMY1807 RU https://pubmed.ncbi.nlm.nih.gov/17292607 DMY1807 DI DMY1807 DMY1807 DN LRHYLNLLTRQRY-NH2 DMY1807 MI TTJ6WK9 DMY1807 MN Neuropeptide Y receptor type 2 (NPY2R) DMY1807 MT DTT DMY1807 MA Inhibitor DMY1807 RN A long-acting selective neuropeptide Y2 receptor PEGylated peptide agonist reduces food intake in mice. Bioorg Med Chem Lett. 2007 Apr 1;17(7):1916-9. DMY1807 RU https://pubmed.ncbi.nlm.nih.gov/17292607 DMUBF53 DI DMUBF53 DMUBF53 DN LS-192629 DMUBF53 MI TTSCIUP DMUBF53 MN Oxytocin receptor (OTR) DMUBF53 MT DTT DMUBF53 MA Antagonist DMUBF53 RN Pharmacology of (2S,4Z)-N-[(2S)-2-hydroxy-2-phenylethyl]-4-(methoxyimino) -1-[(2'-methyl[1,1'-biphenyl]-4-yl)carbonyl]-2-pyrrolidinecarboxamide, a ... J Pharmacol Exp Ther. 2003 Jul;306(1):253-61. DMUBF53 RU https://pubmed.ncbi.nlm.nih.gov/12660315 DMUBF53 DI DMUBF53 DMUBF53 DN LS-192629 DMUBF53 MI TT4TFGN DMUBF53 MN Vasopressin V1a receptor (V1AR) DMUBF53 MT DTT DMUBF53 MA Antagonist DMUBF53 RN Pharmacology of (2S,4Z)-N-[(2S)-2-hydroxy-2-phenylethyl]-4-(methoxyimino) -1-[(2'-methyl[1,1'-biphenyl]-4-yl)carbonyl]-2-pyrrolidinecarboxamide, a ... J Pharmacol Exp Ther. 2003 Jul;306(1):253-61. DMUBF53 RU https://pubmed.ncbi.nlm.nih.gov/12660315 DM6WPIS DI DM6WPIS DM6WPIS DN L-Serine DM6WPIS MI TTI1PRE DM6WPIS MN G-protein coupled receptor GPCR33 (GPRC6A) DM6WPIS MT DTT DM6WPIS MA Agonist DM6WPIS RN Deorphanization of GPRC6A: a promiscuous L-alpha-amino acid receptor with preference for basic amino acids. Mol Pharmacol. 2005 Mar;67(3):589-97. DM6WPIS RU https://pubmed.ncbi.nlm.nih.gov/15576628 DMTJ1NH DI DMTJ1NH DMTJ1NH DN L-serine-O-phosphate DMTJ1NH MI TTZHY6R DMTJ1NH MN Glycogen phosphorylase muscle form (GP) DMTJ1NH MT DTT DMTJ1NH MA Inhibitor DMTJ1NH RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMTJ1NH RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMTJ1NH DI DMTJ1NH DMTJ1NH DN L-serine-O-phosphate DMTJ1NH MI TTICZ1O DMTJ1NH MN Metabotropic glutamate receptor 4 (mGluR4) DMTJ1NH MT DTT DMTJ1NH MA Agonist DMTJ1NH RN Serine-O-phosphate has affinity for type IV, but not type I, metabotropic glutamate receptor. Neuroreport. 1993 Sep;4(9):1099-101. DMTJ1NH RU https://pubmed.ncbi.nlm.nih.gov/8106006 DMTJ1NH DI DMTJ1NH DMTJ1NH DN L-serine-O-phosphate DMTJ1NH MI TTWRP2F DMTJ1NH MN Metabotropic glutamate receptor 6 (mGluR6) DMTJ1NH MT DTT DMTJ1NH MA Agonist DMTJ1NH RN Cloning, distribution and functional expression of the human mGlu6 metabotropic glutamate receptor. Neuropharmacology. 1997 Feb;36(2):145-52. DMTJ1NH RU https://pubmed.ncbi.nlm.nih.gov/9144651 DMTJ1NH DI DMTJ1NH DMTJ1NH DN L-serine-O-phosphate DMTJ1NH MI TT0I76D DMTJ1NH MN Metabotropic glutamate receptor 7 (mGluR7) DMTJ1NH MT DTT DMTJ1NH MA Agonist DMTJ1NH RN Binding of [3H](2S,1'S,2'S)-2-(9-xanthylmethyl)-2-(2'-carboxycyclopropyl) glycine ([3H]LY341495) to cell membranes expressing recombinant human group III metabotropic glutamate receptor subtypes. Naunyn Schmiedebergs Arch Pharmacol. 2000 Dec;362(6):546-54. DMTJ1NH RU https://pubmed.ncbi.nlm.nih.gov/11138847 DMTJ1NH DI DMTJ1NH DMTJ1NH DN L-serine-O-phosphate DMTJ1NH MI TT0IFKL DMTJ1NH MN Metabotropic glutamate receptor 8 (mGluR8) DMTJ1NH MT DTT DMTJ1NH MA Agonist DMTJ1NH RN Cloning and functional expression of alternative spliced variants of the human metabotropic glutamate receptor 8. Brain Res Mol Brain Res. 1999 Apr 20;67(2):201-10. DMTJ1NH RU https://pubmed.ncbi.nlm.nih.gov/10216218 DMTJ1NH DI DMTJ1NH DMTJ1NH DN L-serine-O-phosphate DMTJ1NH MI TT9QBI6 DMTJ1NH MN Phosphoinositide dependent protein kinase-1 (PDPK1) DMTJ1NH MT DTT DMTJ1NH MA Inhibitor DMTJ1NH RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMTJ1NH RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMTJ1NH DI DMTJ1NH DMTJ1NH DN L-serine-O-phosphate DMTJ1NH MI TT8QL1J DMTJ1NH MN Protein kinase C theta (PRKCQ) DMTJ1NH MT DTT DMTJ1NH MA Inhibitor DMTJ1NH RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMTJ1NH RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMTJ1NH DI DMTJ1NH DMTJ1NH DN L-serine-O-phosphate DMTJ1NH MI TTLP3GX DMTJ1NH MN Pseudomonas Phosphomannomutase/phosphoglucomutase (Pseudo algC) DMTJ1NH MT DTT DMTJ1NH MA Inhibitor DMTJ1NH RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMTJ1NH RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMTJ1NH DI DMTJ1NH DMTJ1NH DN L-serine-O-phosphate DMTJ1NH MI TTH0KSX DMTJ1NH MN Rhodopsin (RHO) DMTJ1NH MT DTT DMTJ1NH MA Inhibitor DMTJ1NH RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMTJ1NH RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMWVTS3 DI DMWVTS3 DMWVTS3 DN LSN2463359 DMWVTS3 MI TTHS256 DMWVTS3 MN Metabotropic glutamate receptor 5 (mGluR5) DMWVTS3 MT DTT DMWVTS3 MA Modulator (allosteric modulator) DMWVTS3 RN In vitro characterisation of the novel positive allosteric modulators of the mGlu receptor, LSN2463359 and LSN2814617, and their effects on sleep architecture and operant responding in the rat. Neuropharmacology. 2013 Jan;64:224-39. DMWVTS3 RU https://pubmed.ncbi.nlm.nih.gov/22884720 DMV9NP6 DI DMV9NP6 DMV9NP6 DN LSN2814617 DMV9NP6 MI TTHS256 DMV9NP6 MN Metabotropic glutamate receptor 5 (mGluR5) DMV9NP6 MT DTT DMV9NP6 MA Modulator (allosteric modulator) DMV9NP6 RN In vitro characterisation of the novel positive allosteric modulators of the mGlu receptor, LSN2463359 and LSN2814617, and their effects on sleep architecture and operant responding in the rat. Neuropharmacology. 2013 Jan;64:224-39. DMV9NP6 RU https://pubmed.ncbi.nlm.nih.gov/22884720 DM74J10 DI DM74J10 DM74J10 DN LSP1-2111 DM74J10 MI TTICZ1O DM74J10 MN Metabotropic glutamate receptor 4 (mGluR4) DM74J10 MT DTT DM74J10 MA Agonist DM74J10 RN Electrophysiological and behavioral evidence that modulation of metabotropic glutamate receptor 4 with a new agonist reverses experimental parkinsonism. FASEB J. 2009 Oct;23(10):3619-28. DM74J10 RU https://pubmed.ncbi.nlm.nih.gov/19525404 DM74J10 DI DM74J10 DM74J10 DN LSP1-2111 DM74J10 MI TTWRP2F DM74J10 MN Metabotropic glutamate receptor 6 (mGluR6) DM74J10 MT DTT DM74J10 MA Agonist DM74J10 RN Electrophysiological and behavioral evidence that modulation of metabotropic glutamate receptor 4 with a new agonist reverses experimental parkinsonism. FASEB J. 2009 Oct;23(10):3619-28. DM74J10 RU https://pubmed.ncbi.nlm.nih.gov/19525404 DM74J10 DI DM74J10 DM74J10 DN LSP1-2111 DM74J10 MI TT0I76D DM74J10 MN Metabotropic glutamate receptor 7 (mGluR7) DM74J10 MT DTT DM74J10 MA Agonist DM74J10 RN Electrophysiological and behavioral evidence that modulation of metabotropic glutamate receptor 4 with a new agonist reverses experimental parkinsonism. FASEB J. 2009 Oct;23(10):3619-28. DM74J10 RU https://pubmed.ncbi.nlm.nih.gov/19525404 DMBWHGP DI DMBWHGP DMBWHGP DN LSP4-2022 DMBWHGP MI TTICZ1O DMBWHGP MN Metabotropic glutamate receptor 4 (mGluR4) DMBWHGP MT DTT DMBWHGP MA Agonist DMBWHGP RN A novel selective metabotropic glutamate receptor 4 agonist reveals new possibilities for developing subtype selective ligands with therapeutic potential. FASEB J. 2012 Apr;26(4):1682-93. DMBWHGP RU https://pubmed.ncbi.nlm.nih.gov/22223752 DMBWHGP DI DMBWHGP DMBWHGP DN LSP4-2022 DMBWHGP MI TTWRP2F DMBWHGP MN Metabotropic glutamate receptor 6 (mGluR6) DMBWHGP MT DTT DMBWHGP MA Agonist DMBWHGP RN A novel selective metabotropic glutamate receptor 4 agonist reveals new possibilities for developing subtype selective ligands with therapeutic potential. FASEB J. 2012 Apr;26(4):1682-93. DMBWHGP RU https://pubmed.ncbi.nlm.nih.gov/22223752 DMBWHGP DI DMBWHGP DMBWHGP DN LSP4-2022 DMBWHGP MI TT0I76D DMBWHGP MN Metabotropic glutamate receptor 7 (mGluR7) DMBWHGP MT DTT DMBWHGP MA Agonist DMBWHGP RN A novel selective metabotropic glutamate receptor 4 agonist reveals new possibilities for developing subtype selective ligands with therapeutic potential. FASEB J. 2012 Apr;26(4):1682-93. DMBWHGP RU https://pubmed.ncbi.nlm.nih.gov/22223752 DM702WR DI DM702WR DM702WR DN LTC4 DM702WR MI DEPT1ME DM702WR MN Gamma-glutamyltranspeptidase 1 (GGT1) DM702WR MT DME DM702WR MA Metabolism DM702WR RN Gamma-glutamyl compounds: substrate specificity of gamma-glutamyl transpeptidase enzymes. Anal Biochem. 2011 Jul 15;414(2):208-14. DM702WR RU https://www.ncbi.nlm.nih.gov/pubmed/?term=21447318 DM702WR DI DM702WR DM702WR DN LTC4 DM702WR MI DEH6CAO DM702WR MN Gamma-glutamyltranspeptidase 5 (GGT5) DM702WR MT DME DM702WR MA Metabolism DM702WR RN Gamma-glutamyl compounds: substrate specificity of gamma-glutamyl transpeptidase enzymes. Anal Biochem. 2011 Jul 15;414(2):208-14. DM702WR RU https://www.ncbi.nlm.nih.gov/pubmed/?term=21447318 DM702WR DI DM702WR DM702WR DN LTC4 DM702WR MI TTGKOY9 DM702WR MN Leukotriene CysLT1 receptor (CYSLTR1) DM702WR MT DTT DM702WR MA Agonist DM702WR RN Characterization of the human cysteinyl leukotriene CysLT1 receptor. Nature. 1999 Jun 24;399(6738):789-93. DM702WR RU https://pubmed.ncbi.nlm.nih.gov/10391245 DM702WR DI DM702WR DM702WR DN LTC4 DM702WR MI TT0PZR5 DM702WR MN Leukotriene CysLT2 receptor (CYSLTR2) DM702WR MT DTT DM702WR MA Agonist DM702WR RN Molecular cloning and characterization of a second human cysteinyl leukotriene receptor: discovery of a subtype selective agonist. Mol Pharmacol. 2000 Dec;58(6):1601-8. DM702WR RU https://pubmed.ncbi.nlm.nih.gov/11093801 DM702WR DI DM702WR DM702WR DN LTC4 DM702WR MI TTMPART DM702WR MN Uracil nucleotide/cysteinyl leukotriene receptor (GPR17) DM702WR MT DTT DM702WR MA Agonist DM702WR RN The orphan receptor GPR17 identified as a new dual uracil nucleotides/cysteinyl-leukotrienes receptor. EMBO J. 2006 Oct 4;25(19):4615-27. DM702WR RU https://pubmed.ncbi.nlm.nih.gov/16990797 DMIUZX3 DI DMIUZX3 DMIUZX3 DN LTD4 DMIUZX3 MI TTGKOY9 DMIUZX3 MN Leukotriene CysLT1 receptor (CYSLTR1) DMIUZX3 MT DTT DMIUZX3 MA Agonist DMIUZX3 RN Identification, molecular cloning, expression, and characterization of a cysteinyl leukotriene receptor. Mol Pharmacol. 1999 Sep;56(3):657-63. DMIUZX3 RU https://pubmed.ncbi.nlm.nih.gov/10462554 DMIUZX3 DI DMIUZX3 DMIUZX3 DN LTD4 DMIUZX3 MI TT0PZR5 DMIUZX3 MN Leukotriene CysLT2 receptor (CYSLTR2) DMIUZX3 MT DTT DMIUZX3 MA Agonist DMIUZX3 RN Molecular cloning and characterization of a second human cysteinyl leukotriene receptor: discovery of a subtype selective agonist. Mol Pharmacol. 2000 Dec;58(6):1601-8. DMIUZX3 RU https://pubmed.ncbi.nlm.nih.gov/11093801 DMIUZX3 DI DMIUZX3 DMIUZX3 DN LTD4 DMIUZX3 MI TTMPART DMIUZX3 MN Uracil nucleotide/cysteinyl leukotriene receptor (GPR17) DMIUZX3 MT DTT DMIUZX3 MA Agonist DMIUZX3 RN The orphan receptor GPR17 identified as a new dual uracil nucleotides/cysteinyl-leukotrienes receptor. EMBO J. 2006 Oct 4;25(19):4615-27. DMIUZX3 RU https://pubmed.ncbi.nlm.nih.gov/16990797 DMCPB0Q DI DMCPB0Q DMCPB0Q DN LTE4 DMCPB0Q MI TTGKOY9 DMCPB0Q MN Leukotriene CysLT1 receptor (CYSLTR1) DMCPB0Q MT DTT DMCPB0Q MA Agonist DMCPB0Q RN Characterization of the human cysteinyl leukotriene CysLT1 receptor. Nature. 1999 Jun 24;399(6738):789-93. DMCPB0Q RU https://pubmed.ncbi.nlm.nih.gov/10391245 DMCPB0Q DI DMCPB0Q DMCPB0Q DN LTE4 DMCPB0Q MI TT0PZR5 DMCPB0Q MN Leukotriene CysLT2 receptor (CYSLTR2) DMCPB0Q MT DTT DMCPB0Q MA Agonist DMCPB0Q RN Differential signaling of cysteinyl leukotrienes and a novel cysteinyl leukotriene receptor 2 (CysLT agonist, N-methyl-leukotriene C in calcium reporter and beta arrestin assays. Mol Pharmacol. 2011 Feb;79(2):270-8. DMCPB0Q RU https://pubmed.ncbi.nlm.nih.gov/21078884 DMCPB0Q DI DMCPB0Q DMCPB0Q DN LTE4 DMCPB0Q MI DTSYQGK DMCPB0Q MN Multidrug resistance-associated protein 1 (ABCC1) DMCPB0Q MT DTP DMCPB0Q MA Substrate DMCPB0Q RN Transport of glutathione, glucuronate, and sulfate conjugates by the MRP gene-encoded conjugate export pump. Cancer Res. 1996 Mar 1;56(5):988-94. DMCPB0Q RU http://www.ncbi.nlm.nih.gov/pubmed/8640791 DMCPB0Q DI DMCPB0Q DMCPB0Q DN LTE4 DMCPB0Q MI DT3D8F0 DMCPB0Q MN Organic anion transporting polypeptide 1B1 (SLCO1B1) DMCPB0Q MT DTP DMCPB0Q MA Substrate DMCPB0Q RN Organic anion transporting polypeptide 1B1: a genetically polymorphic transporter of major importance for hepatic drug uptake. Pharmacol Rev. 2011 Mar;63(1):157-81. DMCPB0Q RU http://www.ncbi.nlm.nih.gov/pubmed/21245207 DMCPB0Q DI DMCPB0Q DMCPB0Q DN LTE4 DMCPB0Q MI TTAS1QK DMCPB0Q MN Oxoglutarate receptor (OXGR1) DMCPB0Q MT DTT DMCPB0Q MA Agonist DMCPB0Q RN Identification of GPR99 protein as a potential third cysteinyl leukotriene receptor with a preference for leukotriene E4 ligand. J Biol Chem. 2013 Apr 19;288(16):10967-72. DMCPB0Q RU https://pubmed.ncbi.nlm.nih.gov/23504326 DMCPB0Q DI DMCPB0Q DMCPB0Q DN LTE4 DMCPB0Q MI TTMPART DMCPB0Q MN Uracil nucleotide/cysteinyl leukotriene receptor (GPR17) DMCPB0Q MT DTT DMCPB0Q MA Agonist DMCPB0Q RN The recently identified P2Y-like receptor GPR17 is a sensor of brain damage and a new target for brain repair. PLoS One. 2008;3(10):e3579. DMCPB0Q RU https://pubmed.ncbi.nlm.nih.gov/18974869 DMDU6F4 DI DMDU6F4 DMDU6F4 DN LTERHKILHRLLQEGSPSD DMDU6F4 MI TTZAYWL DMDU6F4 MN Estrogen receptor (ESR) DMDU6F4 MT DTT DMDU6F4 MA Inhibitor DMDU6F4 RN Bicyclo[2.2.2]octanes: close structural mimics of the nuclear receptor-binding motif of steroid receptor coactivators. Bioorg Med Chem Lett. 2007 Aug 1;17(15):4118-22. DMDU6F4 RU https://pubmed.ncbi.nlm.nih.gov/17560105 DMP8O6R DI DMP8O6R DMP8O6R DN L-Thiocitrulline DMP8O6R MI TTF10I9 DMP8O6R MN Nitric-oxide synthase inducible (NOS2) DMP8O6R MT DTT DMP8O6R MA Inhibitor DMP8O6R RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMP8O6R RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMFHTBX DI DMFHTBX DMFHTBX DN L-threonine DMFHTBX MI DTW7AE3 DMFHTBX MN Alanine/serine/cysteine/threonine transporter 2 (SLC1A5) DMFHTBX MT DTP DMFHTBX MA Substrate DMFHTBX RN D-Serine Is a Substrate for Neutral Amino Acid Transporters ASCT1/SLC1A4 and ASCT2/SLC1A5, and Is Transported by Both Subtypes in Rat Hippocampal Astrocyte Cultures. PLoS One. 2016 Jun 7;11(6):e0156551. DMFHTBX RU http://www.ncbi.nlm.nih.gov/pubmed/27272177 DM83HWL DI DM83HWL DM83HWL DN L-thyroxine DM83HWL MI DEYWLRK DM83HWL MN Sulfotransferase 1A1 (SULT1A1) DM83HWL MT DME DM83HWL MA Metabolism DM83HWL RN Characterization of human liver thermostable phenol sulfotransferase (SULT1A1) allozymes with 3,3',5-triiodothyronine as the substrate. J Endocrinol. 2001 Dec;171(3):525-32. DM83HWL RU https://www.ncbi.nlm.nih.gov/pubmed/?term=11739018 DM83HWL DI DM83HWL DM83HWL DN L-thyroxine DM83HWL MI DET89OV DM83HWL MN Thyroxine 5-deiodinase (DIO3) DM83HWL MT DME DM83HWL MA Metabolism DM83HWL RN Substitution of cysteine for selenocysteine in the catalytic center of type III iodothyronine deiodinase reduces catalytic efficiency and alters substrate preference. Endocrinology. 2003 Jun;144(6):2505-13. DM83HWL RU https://www.ncbi.nlm.nih.gov/pubmed/?term=12746313 DMW09LB DI DMW09LB DMW09LB DN LTK-14 DMW09LB MI TTVK7SB DMW09LB MN Histone acetyltransferase KAT2B (KAT2B) DMW09LB MT DTT DMW09LB MA Inhibitor DMW09LB RN Specific inhibition of p300-HAT alters global gene expression and represses HIV replication. Chem Biol. 2007 Jun;14(6):645-57. DMW09LB RU https://pubmed.ncbi.nlm.nih.gov/17584612 DMYLONS DI DMYLONS DMYLONS DN L-Tryptophan-L-2-aminoadipic acid DMYLONS MI TTT2SVW DMYLONS MN PPAR-gamma messenger RNA (PPARG mRNA) DMYLONS MT DTT DMYLONS MA Inhibitor DMYLONS RN Tryptophan-containing dipeptide derivatives as potent PPARgamma antagonists: design, synthesis, biological evaluation, and molecular modeling. Eur J Med Chem. 2008 Dec;43(12):2699-716. DMYLONS RU https://pubmed.ncbi.nlm.nih.gov/18329752 DMYU65F DI DMYU65F DMYU65F DN L-Tryptophan-L-arginine DMYU65F MI TTT2SVW DMYU65F MN PPAR-gamma messenger RNA (PPARG mRNA) DMYU65F MT DTT DMYU65F MA Inhibitor DMYU65F RN Tryptophan-containing dipeptide derivatives as potent PPARgamma antagonists: design, synthesis, biological evaluation, and molecular modeling. Eur J Med Chem. 2008 Dec;43(12):2699-716. DMYU65F RU https://pubmed.ncbi.nlm.nih.gov/18329752 DMWZMCA DI DMWZMCA DMWZMCA DN L-Tryptophan-L-asparagine DMWZMCA MI TTT2SVW DMWZMCA MN PPAR-gamma messenger RNA (PPARG mRNA) DMWZMCA MT DTT DMWZMCA MA Inhibitor DMWZMCA RN Tryptophan-containing dipeptide derivatives as potent PPARgamma antagonists: design, synthesis, biological evaluation, and molecular modeling. Eur J Med Chem. 2008 Dec;43(12):2699-716. DMWZMCA RU https://pubmed.ncbi.nlm.nih.gov/18329752 DMVFAD5 DI DMVFAD5 DMVFAD5 DN L-Tryptophan-L-aspartic acid DMVFAD5 MI TTT2SVW DMVFAD5 MN PPAR-gamma messenger RNA (PPARG mRNA) DMVFAD5 MT DTT DMVFAD5 MA Inhibitor DMVFAD5 RN Tryptophan-containing dipeptide derivatives as potent PPARgamma antagonists: design, synthesis, biological evaluation, and molecular modeling. Eur J Med Chem. 2008 Dec;43(12):2699-716. DMVFAD5 RU https://pubmed.ncbi.nlm.nih.gov/18329752 DMNMRHX DI DMNMRHX DMNMRHX DN L-Tryptophan-L-glutamine DMNMRHX MI TTT2SVW DMNMRHX MN PPAR-gamma messenger RNA (PPARG mRNA) DMNMRHX MT DTT DMNMRHX MA Inhibitor DMNMRHX RN Tryptophan-containing dipeptide derivatives as potent PPARgamma antagonists: design, synthesis, biological evaluation, and molecular modeling. Eur J Med Chem. 2008 Dec;43(12):2699-716. DMNMRHX RU https://pubmed.ncbi.nlm.nih.gov/18329752 DMPV5D0 DI DMPV5D0 DMPV5D0 DN L-Tryptophan-L-leucine DMPV5D0 MI TTT2SVW DMPV5D0 MN PPAR-gamma messenger RNA (PPARG mRNA) DMPV5D0 MT DTT DMPV5D0 MA Inhibitor DMPV5D0 RN Tryptophan-containing dipeptide derivatives as potent PPARgamma antagonists: design, synthesis, biological evaluation, and molecular modeling. Eur J Med Chem. 2008 Dec;43(12):2699-716. DMPV5D0 RU https://pubmed.ncbi.nlm.nih.gov/18329752 DMGVELK DI DMGVELK DMGVELK DN L-Tyrosinamide DMGVELK MI TT64REZ DMGVELK MN Neuropeptide Y (NPY) DMGVELK MT DTT DMGVELK MA Inhibitor DMGVELK RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DMGVELK RU https://pubmed.ncbi.nlm.nih.gov/10592235 DMGVELK DI DMGVELK DMGVELK DN L-Tyrosinamide DMGVELK MI TTTZ3EU DMGVELK MN Valacyclovir hydrolase (BPHL) DMGVELK MT DTT DMGVELK MA Inhibitor DMGVELK RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DMGVELK RU https://pubmed.ncbi.nlm.nih.gov/10592235 DMH693E DI DMH693E DMH693E DN Lu AF21934 DMH693E MI TTICZ1O DMH693E MN Metabotropic glutamate receptor 4 (mGluR4) DMH693E MT DTT DMH693E MA Modulator (allosteric modulator) DMH693E RN Synergy between L-DOPA and a novel positive allosteric modulator of metabotropic glutamate receptor 4: implications for Parkinson's disease treatment and dyskinesia. Neuropharmacology. 2013 Mar;66:158-69. DMH693E RU https://pubmed.ncbi.nlm.nih.gov/22491024 DM7F3SE DI DM7F3SE DM7F3SE DN LU302872 DM7F3SE MI TTKRD0G DM7F3SE MN Endothelin A receptor (EDNRA) DM7F3SE MT DTT DM7F3SE MA Antagonist DM7F3SE RN Influence of endothelin receptor antagonists on myocardial protein kinase C isoforms in uraemic cardiomyopathy. Clin Sci (Lond). 2002 Aug;103 Suppl 48:276S-279S. DM7F3SE RU https://pubmed.ncbi.nlm.nih.gov/12193103 DM7F3SE DI DM7F3SE DM7F3SE DN LU302872 DM7F3SE MI TT3ZTGU DM7F3SE MN Endothelin B receptor (EDNRB) DM7F3SE MT DTT DM7F3SE MA Antagonist DM7F3SE RN Influence of endothelin receptor antagonists on myocardial protein kinase C isoforms in uraemic cardiomyopathy. Clin Sci (Lond). 2002 Aug;103 Suppl 48:276S-279S. DM7F3SE RU https://pubmed.ncbi.nlm.nih.gov/12193103 DM2YOVC DI DM2YOVC DM2YOVC DN LU32-176B DM2YOVC MI TTPRKM0 DM2YOVC MN GABA transporter GAT-1 (SLC6A1) DM2YOVC MT DTT DM2YOVC MA Inhibitor DM2YOVC RN First demonstration of a functional role for central nervous system betaine/{gamma}-aminobutyric acid transporter (mGAT2) based on synergistic anti... J Pharmacol Exp Ther. 2005 Feb;312(2):866-74. DM2YOVC RU https://pubmed.ncbi.nlm.nih.gov/15550575 DM2YOVC DI DM2YOVC DM2YOVC DN LU32-176B DM2YOVC MI TTQBMPI DM2YOVC MN Na(+)/Cl(-) betaine/GABA transporter (SLC6A12) DM2YOVC MT DTT DM2YOVC MA Inhibitor DM2YOVC RN First demonstration of a functional role for central nervous system betaine/{gamma}-aminobutyric acid transporter (mGAT2) based on synergistic anti... J Pharmacol Exp Ther. 2005 Feb;312(2):866-74. DM2YOVC RU https://pubmed.ncbi.nlm.nih.gov/15550575 DMGYBSC DI DMGYBSC DMGYBSC DN LU-53439 DMGYBSC MI TTGP7BY DMGYBSC MN Monoamine oxidase type B (MAO-B) DMGYBSC MT DTT DMGYBSC MA Modulator DMGYBSC RN Inhibition of monoamine oxidase type A, but not type B, is an effective means of inducing anticonvulsant activity in the kindling model of epilepsy. J Pharmacol Exp Ther. 1999 Mar;288(3):984-92. DMGYBSC RU https://www.ncbi.nlm.nih.gov/pubmed/10027835 DM34AYV DI DM34AYV DM34AYV DN LU-AA33810 DM34AYV MI TTY6EWA DM34AYV MN Neuropeptide Y receptor type 5 (NPY5R) DM34AYV MT DTT DM34AYV MA Antagonist DM34AYV RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 308). DM34AYV RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=308 DMI9VNO DI DMI9VNO DMI9VNO DN LUDARTIN DMI9VNO MI TTSZLWK DMI9VNO MN Aromatase (CYP19A1) DMI9VNO MT DTT DMI9VNO MA Inhibitor DMI9VNO RN Pharmacophore modeling strategies for the development of novel nonsteroidal inhibitors of human aromatase (CYP19). Bioorg Med Chem Lett. 2010 May 15;20(10):3050-64. DMI9VNO RU https://pubmed.ncbi.nlm.nih.gov/20413308 DMUPQED DI DMUPQED DMUPQED DN LUF-5417 DMUPQED MI TTK25J1 DMUPQED MN Adenosine A1 receptor (ADORA1) DMUPQED MT DTT DMUPQED MA Inhibitor DMUPQED RN 2-Amino-5-benzoyl-4-phenylthiazoles: Development of potent and selective adenosine A1 receptor antagonists. Bioorg Med Chem. 2010 Mar 15;18(6):2195-2203. DMUPQED RU https://pubmed.ncbi.nlm.nih.gov/20188574 DMUPQED DI DMUPQED DMUPQED DN LUF-5417 DMUPQED MI TTM2AOE DMUPQED MN Adenosine A2a receptor (ADORA2A) DMUPQED MT DTT DMUPQED MA Inhibitor DMUPQED RN 2-Amino-5-benzoyl-4-phenylthiazoles: Development of potent and selective adenosine A1 receptor antagonists. Bioorg Med Chem. 2010 Mar 15;18(6):2195-2203. DMUPQED RU https://pubmed.ncbi.nlm.nih.gov/20188574 DMUPQED DI DMUPQED DMUPQED DN LUF-5417 DMUPQED MI TTJFY5U DMUPQED MN Adenosine A3 receptor (ADORA3) DMUPQED MT DTT DMUPQED MA Inhibitor DMUPQED RN 2-Amino-5-benzoyl-4-phenylthiazoles: Development of potent and selective adenosine A1 receptor antagonists. Bioorg Med Chem. 2010 Mar 15;18(6):2195-2203. DMUPQED RU https://pubmed.ncbi.nlm.nih.gov/20188574 DME4O5D DI DME4O5D DME4O5D DN LUF-5433 DME4O5D MI TTK25J1 DME4O5D MN Adenosine A1 receptor (ADORA1) DME4O5D MT DTT DME4O5D MA Inhibitor DME4O5D RN 2-Amino-5-benzoyl-4-phenylthiazoles: Development of potent and selective adenosine A1 receptor antagonists. Bioorg Med Chem. 2010 Mar 15;18(6):2195-2203. DME4O5D RU https://pubmed.ncbi.nlm.nih.gov/20188574 DME4O5D DI DME4O5D DME4O5D DN LUF-5433 DME4O5D MI TTM2AOE DME4O5D MN Adenosine A2a receptor (ADORA2A) DME4O5D MT DTT DME4O5D MA Inhibitor DME4O5D RN 2-Amino-5-benzoyl-4-phenylthiazoles: Development of potent and selective adenosine A1 receptor antagonists. Bioorg Med Chem. 2010 Mar 15;18(6):2195-2203. DME4O5D RU https://pubmed.ncbi.nlm.nih.gov/20188574 DME4O5D DI DME4O5D DME4O5D DN LUF-5433 DME4O5D MI TTJFY5U DME4O5D MN Adenosine A3 receptor (ADORA3) DME4O5D MT DTT DME4O5D MA Inhibitor DME4O5D RN 2-Amino-5-benzoyl-4-phenylthiazoles: Development of potent and selective adenosine A1 receptor antagonists. Bioorg Med Chem. 2010 Mar 15;18(6):2195-2203. DME4O5D RU https://pubmed.ncbi.nlm.nih.gov/20188574 DM0DRO8 DI DM0DRO8 DM0DRO8 DN LUF-5437 DM0DRO8 MI TTM2AOE DM0DRO8 MN Adenosine A2a receptor (ADORA2A) DM0DRO8 MT DTT DM0DRO8 MA Inhibitor DM0DRO8 RN Thiazole and thiadiazole analogues as a novel class of adenosine receptor antagonists. J Med Chem. 2001 Mar 1;44(5):749-62. DM0DRO8 RU https://pubmed.ncbi.nlm.nih.gov/11262085 DM89FBX DI DM89FBX DM89FBX DN LUF-5735 DM89FBX MI TTK25J1 DM89FBX MN Adenosine A1 receptor (ADORA1) DM89FBX MT DTT DM89FBX MA Inhibitor DM89FBX RN 2,4,6-trisubstituted pyrimidines as a new class of selective adenosine A1 receptor antagonists. J Med Chem. 2004 Dec 16;47(26):6529-40. DM89FBX RU https://pubmed.ncbi.nlm.nih.gov/15588088 DMXFD3S DI DMXFD3S DMXFD3S DN LUF-5737 DMXFD3S MI TTK25J1 DMXFD3S MN Adenosine A1 receptor (ADORA1) DMXFD3S MT DTT DMXFD3S MA Inhibitor DMXFD3S RN 2,4,6-trisubstituted pyrimidines as a new class of selective adenosine A1 receptor antagonists. J Med Chem. 2004 Dec 16;47(26):6529-40. DMXFD3S RU https://pubmed.ncbi.nlm.nih.gov/15588088 DMQ3VHR DI DMQ3VHR DMQ3VHR DN LUF-5764 DMQ3VHR MI TTK25J1 DMQ3VHR MN Adenosine A1 receptor (ADORA1) DMQ3VHR MT DTT DMQ3VHR MA Inhibitor DMQ3VHR RN 2,4,6-trisubstituted pyrimidines as a new class of selective adenosine A1 receptor antagonists. J Med Chem. 2004 Dec 16;47(26):6529-40. DMQ3VHR RU https://pubmed.ncbi.nlm.nih.gov/15588088 DMP08QO DI DMP08QO DMP08QO DN LUF-5767 DMP08QO MI TTK25J1 DMP08QO MN Adenosine A1 receptor (ADORA1) DMP08QO MT DTT DMP08QO MA Inhibitor DMP08QO RN 2,4,6-trisubstituted pyrimidines as a new class of selective adenosine A1 receptor antagonists. J Med Chem. 2004 Dec 16;47(26):6529-40. DMP08QO RU https://pubmed.ncbi.nlm.nih.gov/15588088 DMP08QO DI DMP08QO DMP08QO DN LUF-5767 DMP08QO MI TTM2AOE DMP08QO MN Adenosine A2a receptor (ADORA2A) DMP08QO MT DTT DMP08QO MA Inhibitor DMP08QO RN 2,4,6-trisubstituted pyrimidines as a new class of selective adenosine A1 receptor antagonists. J Med Chem. 2004 Dec 16;47(26):6529-40. DMP08QO RU https://pubmed.ncbi.nlm.nih.gov/15588088 DMP08QO DI DMP08QO DMP08QO DN LUF-5767 DMP08QO MI TTJFY5U DMP08QO MN Adenosine A3 receptor (ADORA3) DMP08QO MT DTT DMP08QO MA Inhibitor DMP08QO RN 2,4,6-trisubstituted pyrimidines as a new class of selective adenosine A1 receptor antagonists. J Med Chem. 2004 Dec 16;47(26):6529-40. DMP08QO RU https://pubmed.ncbi.nlm.nih.gov/15588088 DMQZDMH DI DMQZDMH DMQZDMH DN LUF-5816 DMQZDMH MI TTK25J1 DMQZDMH MN Adenosine A1 receptor (ADORA1) DMQZDMH MT DTT DMQZDMH MA Inhibitor DMQZDMH RN 2,6,8-trisubstituted 1-deazapurines as adenosine receptor antagonists. J Med Chem. 2007 Feb 22;50(4):828-34. DMQZDMH RU https://pubmed.ncbi.nlm.nih.gov/17300165 DMQZDMH DI DMQZDMH DMQZDMH DN LUF-5816 DMQZDMH MI TTNE7KG DMQZDMH MN Adenosine A2b receptor (ADORA2B) DMQZDMH MT DTT DMQZDMH MA Inhibitor DMQZDMH RN 2,6,8-trisubstituted 1-deazapurines as adenosine receptor antagonists. J Med Chem. 2007 Feb 22;50(4):828-34. DMQZDMH RU https://pubmed.ncbi.nlm.nih.gov/17300165 DMQZDMH DI DMQZDMH DMQZDMH DN LUF-5816 DMQZDMH MI TTJFY5U DMQZDMH MN Adenosine A3 receptor (ADORA3) DMQZDMH MT DTT DMQZDMH MA Inhibitor DMQZDMH RN 2,6,8-trisubstituted 1-deazapurines as adenosine receptor antagonists. J Med Chem. 2007 Feb 22;50(4):828-34. DMQZDMH RU https://pubmed.ncbi.nlm.nih.gov/17300165 DMYZGIK DI DMYZGIK DMYZGIK DN LUF5831 DMYZGIK MI TTK25J1 DMYZGIK MN Adenosine A1 receptor (ADORA1) DMYZGIK MT DTT DMYZGIK MA Agonist DMYZGIK RN Allosteric modulation, thermodynamics and binding to wild-type and mutant (T277A) adenosine A1 receptors of LUF5831, a novel nonadenosine-like agonist. Br J Pharmacol. 2006 Mar;147(5):533-41. DMYZGIK RU https://pubmed.ncbi.nlm.nih.gov/16444290 DMDHUL8 DI DMDHUL8 DMDHUL8 DN LUF-5833 DMDHUL8 MI TTJFY5U DMDHUL8 MN Adenosine A3 receptor (ADORA3) DMDHUL8 MT DTT DMDHUL8 MA Enhancer DMDHUL8 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 21). DMDHUL8 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=21 DMZQU90 DI DMZQU90 DMZQU90 DN LUF-5853 DMZQU90 MI TTK25J1 DMZQU90 MN Adenosine A1 receptor (ADORA1) DMZQU90 MT DTT DMZQU90 MA Inhibitor DMZQU90 RN A new generation of adenosine receptor antagonists: from di- to trisubstituted aminopyrimidines. Bioorg Med Chem. 2008 Mar 15;16(6):2741-52. DMZQU90 RU https://pubmed.ncbi.nlm.nih.gov/18258439 DMG4YWM DI DMG4YWM DMG4YWM DN LUF-5956 DMG4YWM MI TTK25J1 DMG4YWM MN Adenosine A1 receptor (ADORA1) DMG4YWM MT DTT DMG4YWM MA Inhibitor DMG4YWM RN 2,6-disubstituted and 2,6,8-trisubstituted purines as adenosine receptor antagonists. J Med Chem. 2006 May 18;49(10):2861-7. DMG4YWM RU https://pubmed.ncbi.nlm.nih.gov/16686529 DMG4YWM DI DMG4YWM DMG4YWM DN LUF-5956 DMG4YWM MI TTM2AOE DMG4YWM MN Adenosine A2a receptor (ADORA2A) DMG4YWM MT DTT DMG4YWM MA Inhibitor DMG4YWM RN 2,6-disubstituted and 2,6,8-trisubstituted purines as adenosine receptor antagonists. J Med Chem. 2006 May 18;49(10):2861-7. DMG4YWM RU https://pubmed.ncbi.nlm.nih.gov/16686529 DMG4YWM DI DMG4YWM DMG4YWM DN LUF-5956 DMG4YWM MI TTJFY5U DMG4YWM MN Adenosine A3 receptor (ADORA3) DMG4YWM MT DTT DMG4YWM MA Inhibitor DMG4YWM RN 2,6-disubstituted and 2,6,8-trisubstituted purines as adenosine receptor antagonists. J Med Chem. 2006 May 18;49(10):2861-7. DMG4YWM RU https://pubmed.ncbi.nlm.nih.gov/16686529 DMJFMH9 DI DMJFMH9 DMJFMH9 DN LUF-5957 DMJFMH9 MI TTK25J1 DMJFMH9 MN Adenosine A1 receptor (ADORA1) DMJFMH9 MT DTT DMJFMH9 MA Inhibitor DMJFMH9 RN 2,6-disubstituted and 2,6,8-trisubstituted purines as adenosine receptor antagonists. J Med Chem. 2006 May 18;49(10):2861-7. DMJFMH9 RU https://pubmed.ncbi.nlm.nih.gov/16686529 DMJFMH9 DI DMJFMH9 DMJFMH9 DN LUF-5957 DMJFMH9 MI TTM2AOE DMJFMH9 MN Adenosine A2a receptor (ADORA2A) DMJFMH9 MT DTT DMJFMH9 MA Inhibitor DMJFMH9 RN 2,6-disubstituted and 2,6,8-trisubstituted purines as adenosine receptor antagonists. J Med Chem. 2006 May 18;49(10):2861-7. DMJFMH9 RU https://pubmed.ncbi.nlm.nih.gov/16686529 DMJFMH9 DI DMJFMH9 DMJFMH9 DN LUF-5957 DMJFMH9 MI TTJFY5U DMJFMH9 MN Adenosine A3 receptor (ADORA3) DMJFMH9 MT DTT DMJFMH9 MA Inhibitor DMJFMH9 RN 2,6-disubstituted and 2,6,8-trisubstituted purines as adenosine receptor antagonists. J Med Chem. 2006 May 18;49(10):2861-7. DMJFMH9 RU https://pubmed.ncbi.nlm.nih.gov/16686529 DMR6LIE DI DMR6LIE DMR6LIE DN LUF-5962 DMR6LIE MI TTK25J1 DMR6LIE MN Adenosine A1 receptor (ADORA1) DMR6LIE MT DTT DMR6LIE MA Inhibitor DMR6LIE RN 2,6-disubstituted and 2,6,8-trisubstituted purines as adenosine receptor antagonists. J Med Chem. 2006 May 18;49(10):2861-7. DMR6LIE RU https://pubmed.ncbi.nlm.nih.gov/16686529 DMR6LIE DI DMR6LIE DMR6LIE DN LUF-5962 DMR6LIE MI TTM2AOE DMR6LIE MN Adenosine A2a receptor (ADORA2A) DMR6LIE MT DTT DMR6LIE MA Inhibitor DMR6LIE RN 2,6-disubstituted and 2,6,8-trisubstituted purines as adenosine receptor antagonists. J Med Chem. 2006 May 18;49(10):2861-7. DMR6LIE RU https://pubmed.ncbi.nlm.nih.gov/16686529 DMR6LIE DI DMR6LIE DMR6LIE DN LUF-5962 DMR6LIE MI TTJFY5U DMR6LIE MN Adenosine A3 receptor (ADORA3) DMR6LIE MT DTT DMR6LIE MA Inhibitor DMR6LIE RN 2,6-disubstituted and 2,6,8-trisubstituted purines as adenosine receptor antagonists. J Med Chem. 2006 May 18;49(10):2861-7. DMR6LIE RU https://pubmed.ncbi.nlm.nih.gov/16686529 DMCTM3L DI DMCTM3L DMCTM3L DN LUF-5978 DMCTM3L MI TTK25J1 DMCTM3L MN Adenosine A1 receptor (ADORA1) DMCTM3L MT DTT DMCTM3L MA Inhibitor DMCTM3L RN 2,6,8-trisubstituted 1-deazapurines as adenosine receptor antagonists. J Med Chem. 2007 Feb 22;50(4):828-34. DMCTM3L RU https://pubmed.ncbi.nlm.nih.gov/17300165 DMCTM3L DI DMCTM3L DMCTM3L DN LUF-5978 DMCTM3L MI TTM2AOE DMCTM3L MN Adenosine A2a receptor (ADORA2A) DMCTM3L MT DTT DMCTM3L MA Inhibitor DMCTM3L RN 2,6,8-trisubstituted 1-deazapurines as adenosine receptor antagonists. J Med Chem. 2007 Feb 22;50(4):828-34. DMCTM3L RU https://pubmed.ncbi.nlm.nih.gov/17300165 DMCTM3L DI DMCTM3L DMCTM3L DN LUF-5978 DMCTM3L MI TTNE7KG DMCTM3L MN Adenosine A2b receptor (ADORA2B) DMCTM3L MT DTT DMCTM3L MA Inhibitor DMCTM3L RN 2,6,8-trisubstituted 1-deazapurines as adenosine receptor antagonists. J Med Chem. 2007 Feb 22;50(4):828-34. DMCTM3L RU https://pubmed.ncbi.nlm.nih.gov/17300165 DMCTM3L DI DMCTM3L DMCTM3L DN LUF-5978 DMCTM3L MI TTJFY5U DMCTM3L MN Adenosine A3 receptor (ADORA3) DMCTM3L MT DTT DMCTM3L MA Inhibitor DMCTM3L RN 2,6,8-trisubstituted 1-deazapurines as adenosine receptor antagonists. J Med Chem. 2007 Feb 22;50(4):828-34. DMCTM3L RU https://pubmed.ncbi.nlm.nih.gov/17300165 DMGOIF5 DI DMGOIF5 DMGOIF5 DN LUF-5980 DMGOIF5 MI TTK25J1 DMGOIF5 MN Adenosine A1 receptor (ADORA1) DMGOIF5 MT DTT DMGOIF5 MA Inhibitor DMGOIF5 RN 2,6,8-trisubstituted 1-deazapurines as adenosine receptor antagonists. J Med Chem. 2007 Feb 22;50(4):828-34. DMGOIF5 RU https://pubmed.ncbi.nlm.nih.gov/17300165 DMGOIF5 DI DMGOIF5 DMGOIF5 DN LUF-5980 DMGOIF5 MI TTM2AOE DMGOIF5 MN Adenosine A2a receptor (ADORA2A) DMGOIF5 MT DTT DMGOIF5 MA Inhibitor DMGOIF5 RN 2,6,8-trisubstituted 1-deazapurines as adenosine receptor antagonists. J Med Chem. 2007 Feb 22;50(4):828-34. DMGOIF5 RU https://pubmed.ncbi.nlm.nih.gov/17300165 DMGOIF5 DI DMGOIF5 DMGOIF5 DN LUF-5980 DMGOIF5 MI TTNE7KG DMGOIF5 MN Adenosine A2b receptor (ADORA2B) DMGOIF5 MT DTT DMGOIF5 MA Inhibitor DMGOIF5 RN 2,6,8-trisubstituted 1-deazapurines as adenosine receptor antagonists. J Med Chem. 2007 Feb 22;50(4):828-34. DMGOIF5 RU https://pubmed.ncbi.nlm.nih.gov/17300165 DMGOIF5 DI DMGOIF5 DMGOIF5 DN LUF-5980 DMGOIF5 MI TTJFY5U DMGOIF5 MN Adenosine A3 receptor (ADORA3) DMGOIF5 MT DTT DMGOIF5 MA Inhibitor DMGOIF5 RN 2,6,8-trisubstituted 1-deazapurines as adenosine receptor antagonists. J Med Chem. 2007 Feb 22;50(4):828-34. DMGOIF5 RU https://pubmed.ncbi.nlm.nih.gov/17300165 DMHO3XL DI DMHO3XL DMHO3XL DN LUF-5981 DMHO3XL MI TTK25J1 DMHO3XL MN Adenosine A1 receptor (ADORA1) DMHO3XL MT DTT DMHO3XL MA Inhibitor DMHO3XL RN 2,6,8-trisubstituted 1-deazapurines as adenosine receptor antagonists. J Med Chem. 2007 Feb 22;50(4):828-34. DMHO3XL RU https://pubmed.ncbi.nlm.nih.gov/17300165 DMHO3XL DI DMHO3XL DMHO3XL DN LUF-5981 DMHO3XL MI TTM2AOE DMHO3XL MN Adenosine A2a receptor (ADORA2A) DMHO3XL MT DTT DMHO3XL MA Inhibitor DMHO3XL RN 2,6,8-trisubstituted 1-deazapurines as adenosine receptor antagonists. J Med Chem. 2007 Feb 22;50(4):828-34. DMHO3XL RU https://pubmed.ncbi.nlm.nih.gov/17300165 DMHO3XL DI DMHO3XL DMHO3XL DN LUF-5981 DMHO3XL MI TTNE7KG DMHO3XL MN Adenosine A2b receptor (ADORA2B) DMHO3XL MT DTT DMHO3XL MA Inhibitor DMHO3XL RN 2,6,8-trisubstituted 1-deazapurines as adenosine receptor antagonists. J Med Chem. 2007 Feb 22;50(4):828-34. DMHO3XL RU https://pubmed.ncbi.nlm.nih.gov/17300165 DMHO3XL DI DMHO3XL DMHO3XL DN LUF-5981 DMHO3XL MI TTJFY5U DMHO3XL MN Adenosine A3 receptor (ADORA3) DMHO3XL MT DTT DMHO3XL MA Inhibitor DMHO3XL RN 2,6,8-trisubstituted 1-deazapurines as adenosine receptor antagonists. J Med Chem. 2007 Feb 22;50(4):828-34. DMHO3XL RU https://pubmed.ncbi.nlm.nih.gov/17300165 DM0K75N DI DM0K75N DM0K75N DN LUF-6258 DM0K75N MI TTK25J1 DM0K75N MN Adenosine A1 receptor (ADORA1) DM0K75N MT DTT DM0K75N MA Inhibitor DM0K75N RN Hybrid ortho/allosteric ligands for the adenosine A(1) receptor. J Med Chem. 2010 Apr 22;53(8):3028-37. DM0K75N RU https://pubmed.ncbi.nlm.nih.gov/20345101 DMYRCHV DI DMYRCHV DMYRCHV DN LUFFARIELLOLIDE DMYRCHV MI TTO8QRU DMYRCHV MN Group IIA phospholipase A2 (GIIA sPLA2) DMYRCHV MT DTT DMYRCHV MA Inhibitor DMYRCHV RN Phospholipase A2 inhibitors from marine organisms. J Nat Prod. 1992 Dec;55(12):1701-17. DMYRCHV RU https://pubmed.ncbi.nlm.nih.gov/1294693 DM4ZLUH DI DM4ZLUH DM4ZLUH DN LUPEOL DM4ZLUH MI TT0IHXV DM4ZLUH MN DNA topoisomerase II (TOP2) DM4ZLUH MT DTT DM4ZLUH MA Inhibitor DM4ZLUH RN Screening of triterpenoids isolated from Phyllanthus flexuosus for DNA topoisomerase inhibitory activity. J Nat Prod. 2001 Dec;64(12):1545-7. DM4ZLUH RU https://pubmed.ncbi.nlm.nih.gov/11754608 DM68RPD DI DM68RPD DM68RPD DN L-valine DM68RPD MI DE9B45K DM68RPD MN Cytosolic branched aminotransferase (BCAT1) DM68RPD MT DME DM68RPD MA Metabolism DM68RPD RN Purification, crystallization and preliminary X-ray crystallographic analysis of branched-chain aminotransferase from Deinococcus radiodurans. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2007 Jun 1;63(Pt 6):492-4. DM68RPD RU https://www.ncbi.nlm.nih.gov/pubmed/?term=17554170 DM68RPD DI DM68RPD DM68RPD DN L-valine DM68RPD MI DTBMSWG DM68RPD MN L-type amino acid transporter 3 (SLC43A1) DM68RPD MT DTP DM68RPD MA Substrate DM68RPD RN Identification of a novel system L amino acid transporter structurally distinct from heterodimeric amino acid transporters. J Biol Chem. 2003 Oct 31;278(44):43838-45. DM68RPD RU http://www.ncbi.nlm.nih.gov/pubmed/12930836 DM68RPD DI DM68RPD DM68RPD DN L-valine DM68RPD MI DTK02I1 DM68RPD MN L-type amino acid transporter 4 (SLC43A2) DM68RPD MT DTP DM68RPD MA Substrate DM68RPD RN Anticipation of food intake induces phosphorylation switch to regulate basolateral amino acid transporter LAT4 (SLC43A2) function. J Physiol. 2019 Jan;597(2):521-542. DM68RPD RU http://www.ncbi.nlm.nih.gov/pubmed/30379325 DM68RPD DI DM68RPD DM68RPD DN L-valine DM68RPD MI DESWQMH DM68RPD MN Propionyl-CoA carboxylase beta (PCCB) DM68RPD MT DME DM68RPD MA Metabolism DM68RPD RN How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DM68RPD RU https://www.ncbi.nlm.nih.gov/pubmed/?term=17139284 DM68RPD DI DM68RPD DM68RPD DN L-valine DM68RPD MI DEUPF5K DM68RPD MN Valyl-tRNA synthetase (VARS) DM68RPD MT DME DM68RPD MA Metabolism DM68RPD RN A present-day aminoacyl-tRNA synthetase with ancestral editing properties. RNA. 2007 Jan;13(1):15-21. DM68RPD RU https://www.ncbi.nlm.nih.gov/pubmed/?term=17095543 DMPGT80 DI DMPGT80 DMPGT80 DN L-Val-L-boroPro DMPGT80 MI TTDIGC1 DMPGT80 MN Dipeptidyl peptidase 4 (DPP-4) DMPGT80 MT DTT DMPGT80 MA Inhibitor DMPGT80 RN Synthesis and characterization of constrained peptidomimetic dipeptidyl peptidase IV inhibitors: amino-lactam boroalanines. J Med Chem. 2007 May 17;50(10):2391-8. DMPGT80 RU https://pubmed.ncbi.nlm.nih.gov/17458948 DMH7TNA DI DMH7TNA DMH7TNA DN L-valyl-L-prolinamide DMH7TNA MI TTQ7R2V DMH7TNA MN Tripeptidyl-peptidase II (TPP2) DMH7TNA MT DTT DMH7TNA MA Inhibitor DMH7TNA RN Inhibitors of tripeptidyl peptidase II. 3. Derivation of butabindide by successive structure optimizations leading to a potential general approach ... J Med Chem. 2005 Nov 17;48(23):7333-42. DMH7TNA RU https://pubmed.ncbi.nlm.nih.gov/16279793 DMQZ13A DI DMQZ13A DMQZ13A DN L-valyl-L-proline benzylamide DMQZ13A MI TTQ7R2V DMQZ13A MN Tripeptidyl-peptidase II (TPP2) DMQZ13A MT DTT DMQZ13A MA Inhibitor DMQZ13A RN Inhibitors of tripeptidyl peptidase II. 3. Derivation of butabindide by successive structure optimizations leading to a potential general approach ... J Med Chem. 2005 Nov 17;48(23):7333-42. DMQZ13A RU https://pubmed.ncbi.nlm.nih.gov/16279793 DMX4DRV DI DMX4DRV DMX4DRV DN L-valyl-L-proline hexylamide DMX4DRV MI TTQ7R2V DMX4DRV MN Tripeptidyl-peptidase II (TPP2) DMX4DRV MT DTT DMX4DRV MA Inhibitor DMX4DRV RN Inhibitors of tripeptidyl peptidase II. 3. Derivation of butabindide by successive structure optimizations leading to a potential general approach ... J Med Chem. 2005 Nov 17;48(23):7333-42. DMX4DRV RU https://pubmed.ncbi.nlm.nih.gov/16279793 DMIO405 DI DMIO405 DMIO405 DN LVAYPWT DMIO405 MI TT2THBD DMIO405 MN P2X purinoceptor 3 (P2RX3) DMIO405 MT DTT DMIO405 MA Inhibitor DMIO405 RN Structure-activity relationship studies of spinorphin as a potent and selective human P2X(3) receptor antagonist. J Med Chem. 2007 Sep 6;50(18):4543-7. DMIO405 RU https://pubmed.ncbi.nlm.nih.gov/17676725 DM78Z9D DI DM78Z9D DM78Z9D DN LVVAPWT DM78Z9D MI TT2THBD DM78Z9D MN P2X purinoceptor 3 (P2RX3) DM78Z9D MT DTT DM78Z9D MA Inhibitor DM78Z9D RN Structure-activity relationship studies of spinorphin as a potent and selective human P2X(3) receptor antagonist. J Med Chem. 2007 Sep 6;50(18):4543-7. DM78Z9D RU https://pubmed.ncbi.nlm.nih.gov/17676725 DM1QPG7 DI DM1QPG7 DM1QPG7 DN LVVYPWT DM1QPG7 MI TT2THBD DM1QPG7 MN P2X purinoceptor 3 (P2RX3) DM1QPG7 MT DTT DM1QPG7 MA Inhibitor DM1QPG7 RN Structure-activity relationship studies of spinorphin as a potent and selective human P2X(3) receptor antagonist. J Med Chem. 2007 Sep 6;50(18):4543-7. DM1QPG7 RU https://pubmed.ncbi.nlm.nih.gov/17676725 DMGSVL0 DI DMGSVL0 DMGSVL0 DN LXA4 DMGSVL0 MI TTOJ1NF DMGSVL0 MN FMLP-related receptor I (FPR2) DMGSVL0 MT DTT DMGSVL0 MA Agonist DMGSVL0 RN Resolvin D1 binds human phagocytes with evidence for proresolving receptors. Proc Natl Acad Sci U S A. 2010 Jan 26;107(4):1660-5. DMGSVL0 RU https://pubmed.ncbi.nlm.nih.gov/20080636 DMGSVL0 DI DMGSVL0 DMGSVL0 DN LXA4 DMGSVL0 MI TT7OCUB DMGSVL0 MN G-protein coupled receptor 32 (GPR32) DMGSVL0 MT DTT DMGSVL0 MA Agonist DMGSVL0 RN Resolvin D1 binds human phagocytes with evidence for proresolving receptors. Proc Natl Acad Sci U S A. 2010 Jan 26;107(4):1660-5. DMGSVL0 RU https://pubmed.ncbi.nlm.nih.gov/20080636 DMGSVL0 DI DMGSVL0 DMGSVL0 DN LXA4 DMGSVL0 MI TT16TM5 DMGSVL0 MN N-formyl peptide receptor 3 (FPR3) DMGSVL0 MT DTT DMGSVL0 MA Agonist DMGSVL0 RN Aspirin-triggered 15-epi-lipoxin A4 (LXA4) and LXA4 stable analogues are potent inhibitors of acute inflammation: evidence for anti-inflammatory receptors. J Exp Med. 1997 May 5;185(9):1693-704. DMGSVL0 RU https://pubmed.ncbi.nlm.nih.gov/9151906 DM0LKPE DI DM0LKPE DM0LKPE DN LXT-101 DM0LKPE MI TT8R70G DM0LKPE MN Gonadotropin-releasing hormone receptor (GNRHR) DM0LKPE MT DTT DM0LKPE MA Antagonist DM0LKPE RN In vivo characterization of a novel GnRH (gonadotropin-releasing hormone) antagonist, LXT-101, in normal male rats. Regul Pept. 2006 Sep 11;136(1-3):122-9. DM0LKPE RU https://pubmed.ncbi.nlm.nih.gov/16828893 DM9IU21 DI DM9IU21 DM9IU21 DN LY 165,163 DM9IU21 MI TTSQIFT DM9IU21 MN 5-HT 1A receptor (HTR1A) DM9IU21 MT DTT DM9IU21 MA Agonist DM9IU21 RN Agonist and antagonist actions of antipsychotic agents at 5-HT1A receptors: a [35S]GTPgammaS binding study. Eur J Pharmacol. 1998 Aug 21;355(2-3):245-56. DM9IU21 RU https://pubmed.ncbi.nlm.nih.gov/9760039 DM9IU21 DI DM9IU21 DM9IU21 DN LY 165,163 DM9IU21 MI TTJS8PY DM9IU21 MN 5-HT 6 receptor (HTR6) DM9IU21 MT DTT DM9IU21 MA Agonist DM9IU21 RN Cloning and expression of a novel serotonin receptor with high affinity for tricyclic psychotropic drugs. Mol Pharmacol. 1993 Mar;43(3):320-7. DM9IU21 RU https://pubmed.ncbi.nlm.nih.gov/7680751 DMNB82L DI DMNB82L DMNB82L DN LY063518 DMNB82L MI TTJQOD7 DMNB82L MN 5-HT 2A receptor (HTR2A) DMNB82L MT DTT DMNB82L MA Antagonist DMNB82L RN A novel class of 5-HT2A receptor antagonists: aryl aminoguanidines. Life Sci. 1996;59(15):1259-68. DMNB82L RU https://pubmed.ncbi.nlm.nih.gov/8845011 DMYNCQR DI DMYNCQR DMYNCQR DN LY108742 DMYNCQR MI TTJQOD7 DMYNCQR MN 5-HT 2A receptor (HTR2A) DMYNCQR MT DTT DMYNCQR MA Antagonist DMYNCQR RN Species variations in transmembrane region V of the 5-hydroxytryptamine type 2A receptor alter the structure-activity relationship of certain ergolines and tryptamines. Mol Pharmacol. 1994 Feb;45(2):277-86. DMYNCQR RU https://pubmed.ncbi.nlm.nih.gov/8114677 DMT0JXC DI DMT0JXC DMT0JXC DN LY134046 DMT0JXC MI TT0NZIC DMT0JXC MN Phenylethanolamine N-methyltransferase (PNMT) DMT0JXC MT DTT DMT0JXC MA Inhibitor DMT0JXC RN Properties of 8,9-dichloro-2,3,4,5-tetrahydro-1H-2-benzazepine, an inhibitor of norepinephrine N-methyltransferase. Biochem Pharmacol. 1981 Jun 1;30(11):1345-52. DMT0JXC RU https://pubmed.ncbi.nlm.nih.gov/6268095 DMI01YM DI DMI01YM DMI01YM DN LY178002 DMI01YM MI TT9V5JH DMI01YM MN Phospholipase A2 (PLA2G1B) DMI01YM MT DTT DMI01YM MA Inhibitor DMI01YM RN The anti-inflammatory effects of LY178002 and LY256548. Agents Actions. 1989 Jun;27(3-4):300-2. DMI01YM RU https://pubmed.ncbi.nlm.nih.gov/2508442 DMVHQGF DI DMVHQGF DMVHQGF DN LY2033298 DMVHQGF MI TTOXS3C DMVHQGF MN Muscarinic acetylcholine receptor (CHRM) DMVHQGF MT DTT DMVHQGF MA Modulator (allosteric modulator) DMVHQGF RN Allosteric modulation of the muscarinic M4 receptor as an approach to treating schizophrenia. Proc Natl Acad Sci U S A. 2008 Aug 5;105(31):10978-83. DMVHQGF RU https://pubmed.ncbi.nlm.nih.gov/18678919 DMIS82X DI DMIS82X DMIS82X DN LY2087101 DMIS82X MI TTF4E0J DMIS82X MN Neuronal acetylcholine receptor alpha-2 (CHRNA2) DMIS82X MT DTT DMIS82X MA Modulator (allosteric modulator) DMIS82X RN Identification and pharmacological profile of a new class of selective nicotinic acetylcholine receptor potentiators. J Pharmacol Exp Ther. 2006 Sep;318(3):1108-17. DMIS82X RU https://pubmed.ncbi.nlm.nih.gov/16738207 DMIS82X DI DMIS82X DMIS82X DN LY2087101 DMIS82X MI TTLA931 DMIS82X MN Neuronal acetylcholine receptor alpha-7 (CHRNA7) DMIS82X MT DTT DMIS82X MA Modulator (allosteric modulator) DMIS82X RN Identification and pharmacological profile of a new class of selective nicotinic acetylcholine receptor potentiators. J Pharmacol Exp Ther. 2006 Sep;318(3):1108-17. DMIS82X RU https://pubmed.ncbi.nlm.nih.gov/16738207 DMIS82X DI DMIS82X DMIS82X DN LY2087101 DMIS82X MI TT5KPZR DMIS82X MN Neuronal acetylcholine receptor beta-2 (CHRNB2) DMIS82X MT DTT DMIS82X MA Modulator (allosteric modulator) DMIS82X RN Identification and pharmacological profile of a new class of selective nicotinic acetylcholine receptor potentiators. J Pharmacol Exp Ther. 2006 Sep;318(3):1108-17. DMIS82X RU https://pubmed.ncbi.nlm.nih.gov/16738207 DMAWTG3 DI DMAWTG3 DMAWTG3 DN LY2109761 DMAWTG3 MI TTP4520 DMAWTG3 MN TGF-beta receptor type I (TGFBR1) DMAWTG3 MT DTT DMAWTG3 MA Inhibitor DMAWTG3 RN LY2109761, a novel transforming growth factor beta receptor type I and type II dual inhibitor, as a therapeutic approach to suppressing pancreatic cancer metastasis. Mol Cancer Ther. 2008 Apr;7(4):829-40. DMAWTG3 RU https://pubmed.ncbi.nlm.nih.gov/18413796 DMAWTG3 DI DMAWTG3 DMAWTG3 DN LY2109761 DMAWTG3 MI TTZE3P7 DMAWTG3 MN TGF-beta receptor type II (TGFBR2) DMAWTG3 MT DTT DMAWTG3 MA Inhibitor DMAWTG3 RN LY2109761, a novel transforming growth factor beta receptor type I and type II dual inhibitor, as a therapeutic approach to suppressing pancreatic cancer metastasis. Mol Cancer Ther. 2008 Apr;7(4):829-40. DMAWTG3 RU https://pubmed.ncbi.nlm.nih.gov/18413796 DM4IELQ DI DM4IELQ DM4IELQ DN LY2119620 DM4IELQ MI TTOXS3C DM4IELQ MN Muscarinic acetylcholine receptor (CHRM) DM4IELQ MT DTT DM4IELQ MA Modulator (allosteric modulator) DM4IELQ RN Characterization of the novel positive allosteric modulator, LY2119620, at the muscarinic M(2) and M(4) receptors. Mol Pharmacol. 2014 Jul;86(1):106-15. DM4IELQ RU https://pubmed.ncbi.nlm.nih.gov/24807965 DMKZJVA DI DMKZJVA DMKZJVA DN LY214352 DMKZJVA MI TT3PQ2Y DMKZJVA MN Plasmodium Dihydroorotate dehydrogenase (Malaria DHOdehase) DMKZJVA MT DTT DMKZJVA MA Inhibitor DMKZJVA RN Identification of a new antifungal target site through a dual biochemical and molecular-genetics approach. Curr Genet. 1996 Jul 31;30(2):159-65. DMKZJVA RU https://pubmed.ncbi.nlm.nih.gov/8660469 DM5RG7J DI DM5RG7J DM5RG7J DN LY215840 DM5RG7J MI TTJQOD7 DM5RG7J MN 5-HT 2A receptor (HTR2A) DM5RG7J MT DTT DM5RG7J MA Antagonist DM5RG7J RN Species variations in transmembrane region V of the 5-hydroxytryptamine type 2A receptor alter the structure-activity relationship of certain ergolines and tryptamines. Mol Pharmacol. 1994 Feb;45(2):277-86. DM5RG7J RU https://pubmed.ncbi.nlm.nih.gov/8114677 DM8SU6N DI DM8SU6N DM8SU6N DN LY-2183240 DM8SU6N MI TTDP1UC DM8SU6N MN Fatty acid amide hydrolase (FAAH) DM8SU6N MT DTT DM8SU6N MA Inhibitor DM8SU6N RN Discovery and development of fatty acid amide hydrolase (FAAH) inhibitors. J Med Chem. 2008 Dec 11;51(23):7327-43. DM8SU6N RU https://pubmed.ncbi.nlm.nih.gov/18983142 DM5VWCI DI DM5VWCI DM5VWCI DN Ly231514 Tetra Glu DM5VWCI MI TTU6BFZ DM5VWCI MN Candida Thymidylate synthase (Candi TMP1) DM5VWCI MT DTT DM5VWCI MA Inhibitor DM5VWCI RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DM5VWCI RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMPV6N9 DI DMPV6N9 DMPV6N9 DN LY-2318912 DMPV6N9 MI TTDP1UC DMPV6N9 MN Fatty acid amide hydrolase (FAAH) DMPV6N9 MT DTT DMPV6N9 MA Inhibitor DMPV6N9 RN Carbamoyl tetrazoles as inhibitors of endocannabinoid inactivation: a critical revisitation. Eur J Med Chem. 2008 Jan;43(1):62-72. DMPV6N9 RU https://pubmed.ncbi.nlm.nih.gov/17452063 DMC82DA DI DMC82DA DMC82DA DN LY233053 DMC82DA MI TTKJEMQ DMC82DA MN Glutamate receptor ionotropic NMDA 2A (NMDAR2A) DMC82DA MT DTT DMC82DA MA Antagonist DMC82DA RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 456). DMC82DA RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=456 DMC82DA DI DMC82DA DMC82DA DN LY233053 DMC82DA MI TTN9D8E DMC82DA MN Glutamate receptor ionotropic NMDA 2B (NMDAR2B) DMC82DA MT DTT DMC82DA MA Antagonist DMC82DA RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 457). DMC82DA RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=457 DMC82DA DI DMC82DA DMC82DA DN LY233053 DMC82DA MI TT1M8OW DMC82DA MN Glutamate receptor ionotropic NMDA 2C (GluN2C) DMC82DA MT DTT DMC82DA MA Antagonist DMC82DA RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 458). DMC82DA RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=458 DMC82DA DI DMC82DA DMC82DA DN LY233053 DMC82DA MI TT5POTG DMC82DA MN Glutamate receptor ionotropic NMDA 2D (GluN2D) DMC82DA MT DTT DMC82DA MA Antagonist DMC82DA RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 459). DMC82DA RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=459 DMBFLOJ DI DMBFLOJ DMBFLOJ DN LY2365109 DMBFLOJ MI TTHJTF7 DMBFLOJ MN Glycine transporter GlyT-1 (SLC6A9) DMBFLOJ MT DTT DMBFLOJ MA Inhibitor DMBFLOJ RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 935). DMBFLOJ RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=935 DM1KCHN DI DM1KCHN DM1KCHN DN LY256548 DM1KCHN MI TT9V5JH DM1KCHN MN Phospholipase A2 (PLA2G1B) DM1KCHN MT DTT DM1KCHN MA Binder DM1KCHN RN The anti-inflammatory effects of LY178002 and LY256548. Agents Actions. 1989 Jun;27(3-4):300-2. DM1KCHN RU https://pubmed.ncbi.nlm.nih.gov/2508442 DMX5H3T DI DMX5H3T DMX5H3T DN LY-266111 DMX5H3T MI TTTU72V DMX5H3T MN Steroid 5-alpha-reductase 1 (SRD5A1) DMX5H3T MT DTT DMX5H3T MA Inhibitor DMX5H3T RN Simple bi- and tricyclic inhibitors of human steroid 5alpha-reductase. Bioorg Med Chem Lett. 2000 Sep 4;10(17):1909-11. DMX5H3T RU https://pubmed.ncbi.nlm.nih.gov/10987415 DMHC853 DI DMHC853 DMHC853 DN LY266500 DMHC853 MI TTYX5QR DMHC853 MN Pseudomonas Histidine kinase AlgR2 (Pseudo algQ) DMHC853 MT DTT DMHC853 MA Inhibitor DMHC853 RN Histidine kinases as targets for new antimicrobial agents. Bioorg Med Chem. 2002 Apr;10(4):855-67. DMHC853 RU https://pubmed.ncbi.nlm.nih.gov/11836091 DMBSFDE DI DMBSFDE DMBSFDE DN LY-282210 DMBSFDE MI TTN53ZF DMBSFDE MN Leukotriene B4 receptor 1 (LTB4R) DMBSFDE MT DTT DMBSFDE MA Inhibitor DMBSFDE RN Biphenylyl-substituted xanthones: highly potent leukotriene B4 receptor antagonists. J Med Chem. 1993 Nov 26;36(24):3982-4. DMBSFDE RU https://pubmed.ncbi.nlm.nih.gov/8254628 DMBSFDE DI DMBSFDE DMBSFDE DN LY-282210 DMBSFDE MI TTVJX54 DMBSFDE MN Leukotriene B4 receptor 2 (LTB4R2) DMBSFDE MT DTT DMBSFDE MA Inhibitor DMBSFDE RN Biphenylyl-substituted xanthones: highly potent leukotriene B4 receptor antagonists. J Med Chem. 1993 Nov 26;36(24):3982-4. DMBSFDE RU https://pubmed.ncbi.nlm.nih.gov/8254628 DML36ZE DI DML36ZE DML36ZE DN LY-292223 DML36ZE MI TTL69WB DML36ZE MN Angiotensin-converting enzyme (ACE) DML36ZE MT DTT DML36ZE MA Inhibitor DML36ZE RN Endothelin-converting enzyme-1 inhibition and growth of human glioblastoma cells. J Med Chem. 2005 Jan 27;48(2):483-98. DML36ZE RU https://pubmed.ncbi.nlm.nih.gov/15658862 DML36ZE DI DML36ZE DML36ZE DN LY-292223 DML36ZE MI TTK3PY9 DML36ZE MN DNA-dependent protein kinase catalytic (PRKDC) DML36ZE MT DTT DML36ZE MA Inhibitor DML36ZE RN Identification of a highly potent and selective DNA-dependent protein kinase (DNA-PK) inhibitor (NU7441) by screening of chromenone libraries. Bioorg Med Chem Lett. 2004 Dec 20;14(24):6083-7. DML36ZE RU https://pubmed.ncbi.nlm.nih.gov/15546735 DML36ZE DI DML36ZE DML36ZE DN LY-292223 DML36ZE MI TTQ9RYT DML36ZE MN Endothelin-converting enzyme 1 (ECE1) DML36ZE MT DTT DML36ZE MA Inhibitor DML36ZE RN Endothelin-converting enzyme-1 inhibition and growth of human glioblastoma cells. J Med Chem. 2005 Jan 27;48(2):483-98. DML36ZE RU https://pubmed.ncbi.nlm.nih.gov/15658862 DML36ZE DI DML36ZE DML36ZE DN LY-292223 DML36ZE MI TT9H4P3 DML36ZE MN PI3K p110 beta messenger RNA (PIK3CB mRNA) DML36ZE MT DTT DML36ZE MA Inhibitor DML36ZE RN LY294002-geldanamycin heterodimers as selective inhibitors of the PI3K and PI3K-related family. Bioorg Med Chem Lett. 2001 Apr 9;11(7):909-13. DML36ZE RU https://pubmed.ncbi.nlm.nih.gov/11294389 DML36ZE DI DML36ZE DML36ZE DN LY-292223 DML36ZE MI TTGBPJE DML36ZE MN PI3-kinase delta (PIK3CD) DML36ZE MT DTT DML36ZE MA Inhibitor DML36ZE RN LY294002-geldanamycin heterodimers as selective inhibitors of the PI3K and PI3K-related family. Bioorg Med Chem Lett. 2001 Apr 9;11(7):909-13. DML36ZE RU https://pubmed.ncbi.nlm.nih.gov/11294389 DML36ZE DI DML36ZE DML36ZE DN LY-292223 DML36ZE MI TTHBTOP DML36ZE MN PI3-kinase gamma (PIK3CG) DML36ZE MT DTT DML36ZE MA Inhibitor DML36ZE RN LY294002-geldanamycin heterodimers as selective inhibitors of the PI3K and PI3K-related family. Bioorg Med Chem Lett. 2001 Apr 9;11(7):909-13. DML36ZE RU https://pubmed.ncbi.nlm.nih.gov/11294389 DM2HQ9O DI DM2HQ9O DM2HQ9O DN LY301875 DM2HQ9O MI TT8DBY3 DM2HQ9O MN Angiotensin II receptor type-1 (AGTR1) DM2HQ9O MT DTT DM2HQ9O MA Antagonist DM2HQ9O RN Inhibition of angiotensin II-induced inositol phosphate production by triacid nonpeptide antagonists in CHO cells expressing human AT1 receptors. Pharm Res. 2000 Dec;17(12):1482-8. DM2HQ9O RU https://pubmed.ncbi.nlm.nih.gov/11303957 DMY9WTE DI DMY9WTE DMY9WTE DN LY303336 DMY9WTE MI TT8DBY3 DMY9WTE MN Angiotensin II receptor type-1 (AGTR1) DMY9WTE MT DTT DMY9WTE MA Antagonist DMY9WTE RN Inhibition of angiotensin II-induced inositol phosphate production by triacid nonpeptide antagonists in CHO cells expressing human AT1 receptors. Pharm Res. 2000 Dec;17(12):1482-8. DMY9WTE RU https://pubmed.ncbi.nlm.nih.gov/11303957 DMWAHYX DI DMWAHYX DMWAHYX DN LY314228 DMWAHYX MI TTJQOD7 DMWAHYX MN 5-HT 2A receptor (HTR2A) DMWAHYX MT DTT DMWAHYX MA Antagonist DMWAHYX RN A novel class of 5-HT2A receptor antagonists: aryl aminoguanidines. Life Sci. 1996;59(15):1259-68. DMWAHYX RU https://pubmed.ncbi.nlm.nih.gov/8845011 DMD2J97 DI DMD2J97 DMD2J97 DN LY-314657 DMD2J97 MI TTAN6JD DMD2J97 MN Glutamate receptor AMPA (GRIA) DMD2J97 MT DTT DMD2J97 MA Modulator DMD2J97 RN The ChEMBL database in 2017. Nucleic Acids Res. 2017 Jan 4;45(D1):D945-D954. DMD2J97 RU https://www.ncbi.nlm.nih.gov/pubmed/27899562 DMK3Y5U DI DMK3Y5U DMK3Y5U DN LY320135 DMK3Y5U MI TT6OEDT DMK3Y5U MN Cannabinoid receptor 1 (CB1) DMK3Y5U MT DTT DMK3Y5U MA Antagonist DMK3Y5U RN LY320135, a novel cannabinoid CB1 receptor antagonist, unmasks coupling of the CB1 receptor to stimulation of cAMP accumulation. J Pharmacol Exp Ther. 1998 Jan;284(1):291-7. DMK3Y5U RU https://pubmed.ncbi.nlm.nih.gov/9435190 DM3DOI7 DI DM3DOI7 DM3DOI7 DN LY320954 DM3DOI7 MI TTJQOD7 DM3DOI7 MN 5-HT 2A receptor (HTR2A) DM3DOI7 MT DTT DM3DOI7 MA Antagonist DM3DOI7 RN A novel class of 5-HT2A receptor antagonists: aryl aminoguanidines. Life Sci. 1996;59(15):1259-68. DM3DOI7 RU https://pubmed.ncbi.nlm.nih.gov/8845011 DMN53M4 DI DMN53M4 DMN53M4 DN LY-326449 DMN53M4 MI TT7A1BO DMN53M4 MN PKC-delta messenger RNA (PRKCD mRNA) DMN53M4 MT DTT DMN53M4 MA Inhibitor DMN53M4 RN (S)-13-[(dimethylamino)methyl]-10,11,14,15-tetrahydro-4,9:16, 21-dimetheno-1H, 13H-dibenzo[e,k]pyrrolo[3,4-h][1,4,13]oxadiazacyclohexadecene-1,3(2H... J Med Chem. 1996 Jul 5;39(14):2664-71. DMN53M4 RU https://pubmed.ncbi.nlm.nih.gov/8709095 DMN53M4 DI DMN53M4 DMN53M4 DN LY-326449 DMN53M4 MI TTONI0R DMN53M4 MN PKC-eta messenger RNA (PRKCH mRNA) DMN53M4 MT DTT DMN53M4 MA Inhibitor DMN53M4 RN (S)-13-[(dimethylamino)methyl]-10,11,14,15-tetrahydro-4,9:16, 21-dimetheno-1H, 13H-dibenzo[e,k]pyrrolo[3,4-h][1,4,13]oxadiazacyclohexadecene-1,3(2H... J Med Chem. 1996 Jul 5;39(14):2664-71. DMN53M4 RU https://pubmed.ncbi.nlm.nih.gov/8709095 DMN53M4 DI DMN53M4 DMN53M4 DN LY-326449 DMN53M4 MI TTBSN0L DMN53M4 MN PKC-zeta messenger RNA (PRKCZ mRNA) DMN53M4 MT DTT DMN53M4 MA Inhibitor DMN53M4 RN (S)-13-[(dimethylamino)methyl]-10,11,14,15-tetrahydro-4,9:16, 21-dimetheno-1H, 13H-dibenzo[e,k]pyrrolo[3,4-h][1,4,13]oxadiazacyclohexadecene-1,3(2H... J Med Chem. 1996 Jul 5;39(14):2664-71. DMN53M4 RU https://pubmed.ncbi.nlm.nih.gov/8709095 DMN53M4 DI DMN53M4 DMN53M4 DN LY-326449 DMN53M4 MI TTFJ8Q1 DMN53M4 MN Protein kinase C alpha (PRKCA) DMN53M4 MT DTT DMN53M4 MA Inhibitor DMN53M4 RN (S)-13-[(dimethylamino)methyl]-10,11,14,15-tetrahydro-4,9:16, 21-dimetheno-1H, 13H-dibenzo[e,k]pyrrolo[3,4-h][1,4,13]oxadiazacyclohexadecene-1,3(2H... J Med Chem. 1996 Jul 5;39(14):2664-71. DMN53M4 RU https://pubmed.ncbi.nlm.nih.gov/8709095 DMN53M4 DI DMN53M4 DMN53M4 DN LY-326449 DMN53M4 MI TTYPXQF DMN53M4 MN Protein kinase C beta (PRKCB) DMN53M4 MT DTT DMN53M4 MA Inhibitor DMN53M4 RN (S)-13-[(dimethylamino)methyl]-10,11,14,15-tetrahydro-4,9:16, 21-dimetheno-1H, 13H-dibenzo[e,k]pyrrolo[3,4-h][1,4,13]oxadiazacyclohexadecene-1,3(2H... J Med Chem. 1996 Jul 5;39(14):2664-71. DMN53M4 RU https://pubmed.ncbi.nlm.nih.gov/8709095 DMN53M4 DI DMN53M4 DMN53M4 DN LY-326449 DMN53M4 MI TT9WJ8U DMN53M4 MN Protein kinase C delta (PRKCD) DMN53M4 MT DTT DMN53M4 MA Inhibitor DMN53M4 RN (S)-13-[(dimethylamino)methyl]-10,11,14,15-tetrahydro-4,9:16, 21-dimetheno-1H, 13H-dibenzo[e,k]pyrrolo[3,4-h][1,4,13]oxadiazacyclohexadecene-1,3(2H... J Med Chem. 1996 Jul 5;39(14):2664-71. DMN53M4 RU https://pubmed.ncbi.nlm.nih.gov/8709095 DMN53M4 DI DMN53M4 DMN53M4 DN LY-326449 DMN53M4 MI TTBZ7OD DMN53M4 MN Protein kinase C epsilon (PRKCE) DMN53M4 MT DTT DMN53M4 MA Inhibitor DMN53M4 RN (S)-13-[(dimethylamino)methyl]-10,11,14,15-tetrahydro-4,9:16, 21-dimetheno-1H, 13H-dibenzo[e,k]pyrrolo[3,4-h][1,4,13]oxadiazacyclohexadecene-1,3(2H... J Med Chem. 1996 Jul 5;39(14):2664-71. DMN53M4 RU https://pubmed.ncbi.nlm.nih.gov/8709095 DMN53M4 DI DMN53M4 DMN53M4 DN LY-326449 DMN53M4 MI TTRFOXJ DMN53M4 MN Protein kinase C gamma (PRKCG) DMN53M4 MT DTT DMN53M4 MA Inhibitor DMN53M4 RN (S)-13-[(dimethylamino)methyl]-10,11,14,15-tetrahydro-4,9:16, 21-dimetheno-1H, 13H-dibenzo[e,k]pyrrolo[3,4-h][1,4,13]oxadiazacyclohexadecene-1,3(2H... J Med Chem. 1996 Jul 5;39(14):2664-71. DMN53M4 RU https://pubmed.ncbi.nlm.nih.gov/8709095 DMN53M4 DI DMN53M4 DMN53M4 DN LY-326449 DMN53M4 MI TT8QL1J DMN53M4 MN Protein kinase C theta (PRKCQ) DMN53M4 MT DTT DMN53M4 MA Inhibitor DMN53M4 RN (S)-13-[(dimethylamino)methyl]-10,11,14,15-tetrahydro-4,9:16, 21-dimetheno-1H, 13H-dibenzo[e,k]pyrrolo[3,4-h][1,4,13]oxadiazacyclohexadecene-1,3(2H... J Med Chem. 1996 Jul 5;39(14):2664-71. DMN53M4 RU https://pubmed.ncbi.nlm.nih.gov/8709095 DMN53M4 DI DMN53M4 DMN53M4 DN LY-326449 DMN53M4 MI TTUWGRA DMN53M4 MN Protein kinase C zeta (PRKCZ) DMN53M4 MT DTT DMN53M4 MA Inhibitor DMN53M4 RN (S)-13-[(dimethylamino)methyl]-10,11,14,15-tetrahydro-4,9:16, 21-dimetheno-1H, 13H-dibenzo[e,k]pyrrolo[3,4-h][1,4,13]oxadiazacyclohexadecene-1,3(2H... J Med Chem. 1996 Jul 5;39(14):2664-71. DMN53M4 RU https://pubmed.ncbi.nlm.nih.gov/8709095 DMFHT3U DI DMFHT3U DMFHT3U DN LY334362 DMFHT3U MI TTWJBZ5 DMFHT3U MN 5-HT 2C receptor (HTR2C) DMFHT3U MT DTT DMFHT3U MA Antagonist DMFHT3U RN A novel class of 5-HT2A receptor antagonists: aryl aminoguanidines. Life Sci. 1996;59(15):1259-68. DMFHT3U RU https://pubmed.ncbi.nlm.nih.gov/8845011 DMUXFZQ DI DMUXFZQ DMUXFZQ DN LY-3390334 DMUXFZQ MI TTVBPDM DMUXFZQ MN Metabotropic glutamate receptor 1 (mGluR1) DMUXFZQ MT DTT DMUXFZQ MA Modulator DMUXFZQ RN Inhibition of group I metabotropic glutamate receptor responses in vivo in rats by a new generation of carboxyphenylglycine-like amino acid antagon... Neurosci Lett. 2002 Sep 20;330(2):127-30. DMUXFZQ RU https://www.ncbi.nlm.nih.gov/pubmed/12231428 DMUXFZQ DI DMUXFZQ DMUXFZQ DN LY-3390334 DMUXFZQ MI TTHS256 DMUXFZQ MN Metabotropic glutamate receptor 5 (mGluR5) DMUXFZQ MT DTT DMUXFZQ MA Modulator DMUXFZQ RN Inhibition of group I metabotropic glutamate receptor responses in vivo in rats by a new generation of carboxyphenylglycine-like amino acid antagon... Neurosci Lett. 2002 Sep 20;330(2):127-30. DMUXFZQ RU https://www.ncbi.nlm.nih.gov/pubmed/12231428 DM8S7AO DI DM8S7AO DM8S7AO DN LY339434 DM8S7AO MI TT0MYE2 DM8S7AO MN Glutamate receptor ionotropic kainate 1 (GRIK1) DM8S7AO MT DTT DM8S7AO MA Agonist DM8S7AO RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 450). DM8S7AO RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=450 DMS7KW8 DI DMS7KW8 DMS7KW8 DN LY341770 DMS7KW8 MI TTU6BFZ DMS7KW8 MN Candida Thymidylate synthase (Candi TMP1) DMS7KW8 MT DTT DMS7KW8 MA Inhibitor DMS7KW8 RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMS7KW8 RU https://pubmed.ncbi.nlm.nih.gov/17139284 DM8LSQP DI DM8LSQP DM8LSQP DN LY344864 DM8LSQP MI TT0MI3F DM8LSQP MN 5-HT 1F receptor (HTR1F) DM8LSQP MT DTT DM8LSQP MA Agonist DM8LSQP RN 5-Hydroxytryptamine(1F) receptors do not participate in vasoconstriction: lack of vasoconstriction to LY344864, a selective serotonin(1F) receptor agonist in rabbit saphenous vein. J Pharmacol Exp Ther. 1999 Sep;290(3):935-9. DM8LSQP RU https://pubmed.ncbi.nlm.nih.gov/10454462 DMME40U DI DMME40U DMME40U DN LY-379268 DMME40U MI TTXJ47W DMME40U MN Metabotropic glutamate receptor 2 (mGluR2) DMME40U MT DTT DMME40U MA Inhibitor DMME40U RN Synthesis and metabotropic glutamate receptor activity of S-oxidized variants of (-)-4-amino-2-thiabicyclo-[3.1.0]hexane-4,6-dicarboxylate: identif... J Med Chem. 2007 Jan 25;50(2):233-40. DMME40U RU https://pubmed.ncbi.nlm.nih.gov/17228865 DMME40U DI DMME40U DMME40U DN LY-379268 DMME40U MI TT8A9EF DMME40U MN Metabotropic glutamate receptor 3 (mGluR3) DMME40U MT DTT DMME40U MA Inhibitor DMME40U RN Synthesis and metabotropic glutamate receptor activity of S-oxidized variants of (-)-4-amino-2-thiabicyclo-[3.1.0]hexane-4,6-dicarboxylate: identif... J Med Chem. 2007 Jan 25;50(2):233-40. DMME40U RU https://pubmed.ncbi.nlm.nih.gov/17228865 DMWKYFO DI DMWKYFO DMWKYFO DN LY382884 DMWKYFO MI TT0MYE2 DMWKYFO MN Glutamate receptor ionotropic kainate 1 (GRIK1) DMWKYFO MT DTT DMWKYFO MA Antagonist DMWKYFO RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 450). DMWKYFO RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=450 DM6Y2XG DI DM6Y2XG DM6Y2XG DN LY-389795 DM6Y2XG MI TTXJ47W DM6Y2XG MN Metabotropic glutamate receptor 2 (mGluR2) DM6Y2XG MT DTT DM6Y2XG MA Inhibitor DM6Y2XG RN Synthesis and metabotropic glutamate receptor activity of S-oxidized variants of (-)-4-amino-2-thiabicyclo-[3.1.0]hexane-4,6-dicarboxylate: identif... J Med Chem. 2007 Jan 25;50(2):233-40. DM6Y2XG RU https://pubmed.ncbi.nlm.nih.gov/17228865 DM6Y2XG DI DM6Y2XG DM6Y2XG DN LY-389795 DM6Y2XG MI TT8A9EF DM6Y2XG MN Metabotropic glutamate receptor 3 (mGluR3) DM6Y2XG MT DTT DM6Y2XG MA Inhibitor DM6Y2XG RN Synthesis and metabotropic glutamate receptor activity of S-oxidized variants of (-)-4-amino-2-thiabicyclo-[3.1.0]hexane-4,6-dicarboxylate: identif... J Med Chem. 2007 Jan 25;50(2):233-40. DM6Y2XG RU https://pubmed.ncbi.nlm.nih.gov/17228865 DM1KW0L DI DM1KW0L DM1KW0L DN LY-392098 DM1KW0L MI TTAN6JD DM1KW0L MN Glutamate receptor AMPA (GRIA) DM1KW0L MT DTT DM1KW0L MA Modulator DM1KW0L RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4251). DM1KW0L RU http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=4251 DMHQ0T2 DI DMHQ0T2 DMHQ0T2 DN LY433221 DMHQ0T2 MI TTSQIFT DMHQ0T2 MN 5-HT 1A receptor (HTR1A) DMHQ0T2 MT DTT DMHQ0T2 MA Antagonist DMHQ0T2 RN Serotonin reuptake inhibitors: the corner stone in treatment of depression for half a century--a medicinal chemistry survey. Curr Top Med Chem. 2006;6(17):1801-23. DMHQ0T2 RU https://pubmed.ncbi.nlm.nih.gov/17017959 DMP8OXG DI DMP8OXG DMP8OXG DN LY433222 DMP8OXG MI TTJQOD7 DMP8OXG MN 5-HT 2A receptor (HTR2A) DMP8OXG MT DTT DMP8OXG MA Inhibitor DMP8OXG RN Serotonin reuptake inhibitors: the corner stone in treatment of depression for half a century--a medicinal chemistry survey. Curr Top Med Chem. 2006;6(17):1801-23. DMP8OXG RU https://pubmed.ncbi.nlm.nih.gov/17017959 DM86Y1V DI DM86Y1V DM86Y1V DN LY456066 DM86Y1V MI TTVBPDM DM86Y1V MN Metabotropic glutamate receptor 1 (mGluR1) DM86Y1V MT DTT DM86Y1V MA Modulator (allosteric modulator) DM86Y1V RN Identification of a novel transmembrane domain involved in the negative modulation of mGluR1 using a newly discovered allosteric mGluR1 antagonist, 3-cyclohexyl-5-fluoro-6-methyl-7-(2-morpholin-4-ylethoxy)-4H-chromen-4-one. Neuropharmacology. 2009 Sep;57(4):438-45. DM86Y1V RU https://pubmed.ncbi.nlm.nih.gov/19559036 DMROFX8 DI DMROFX8 DMROFX8 DN LY456236 DMROFX8 MI TTVBPDM DMROFX8 MN Metabotropic glutamate receptor 1 (mGluR1) DMROFX8 MT DTT DMROFX8 MA Modulator (allosteric modulator) DMROFX8 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 289). DMROFX8 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=289 DMK64AZ DI DMK64AZ DMK64AZ DN LY-465608 DMK64AZ MI TTJ584C DMK64AZ MN Peroxisome proliferator-activated receptor alpha (PPARA) DMK64AZ MT DTT DMK64AZ MA Agonist DMK64AZ RN Design and synthesis of alpha-aryloxy-alpha-methylhydrocinnamic acids: a novel class of dual peroxisome proliferator-activated receptor alpha/gamma agonists. J Med Chem. 2004 May 6;47(10):2422-5. DMK64AZ RU https://pubmed.ncbi.nlm.nih.gov/15115385 DMK64AZ DI DMK64AZ DMK64AZ DN LY-465608 DMK64AZ MI TTT2SVW DMK64AZ MN PPAR-gamma messenger RNA (PPARG mRNA) DMK64AZ MT DTT DMK64AZ MA Agonist DMK64AZ RN Design and synthesis of 2-methyl-2-[4-(2-[5-methyl-2-aryloxazol-4-yl]ethoxy)phenoxy]propionic acids: a new class of dual PPARalpha/gamma agonists. J Med Chem. 2001 Jun 21;44(13):2061-4. DMK64AZ RU https://pubmed.ncbi.nlm.nih.gov/11405642 DM97NBO DI DM97NBO DM97NBO DN LY466195 DM97NBO MI TT0MYE2 DM97NBO MN Glutamate receptor ionotropic kainate 1 (GRIK1) DM97NBO MT DTT DM97NBO MA Antagonist DM97NBO RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 450). DM97NBO RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=450 DMQVF41 DI DMQVF41 DMQVF41 DN LY-593039 DMQVF41 MI TTZ9SOR DMQVF41 MN Muscarinic acetylcholine receptor M1 (CHRM1) DMQVF41 MT DTT DMQVF41 MA Agonist DMQVF41 RN Pharmacological comparison of muscarinic ligands: historical versus more recent muscarinic M1-preferring receptor agonists. Eur J Pharmacol. 2009 Mar 1;605(1-3):53-6. DMQVF41 RU https://pubmed.ncbi.nlm.nih.gov/19168056 DMQE89J DI DMQE89J DMQE89J DN LY593093 DMQE89J MI TTOXS3C DMQE89J MN Muscarinic acetylcholine receptor (CHRM) DMQE89J MT DTT DMQE89J MA Agonist DMQE89J RN Pharmacological characterization of LY593093, an M1 muscarinic acetylcholine receptor-selective partial orthosteric agonist. J Pharmacol Exp Ther. 2011 Aug;338(2):622-32. DMQE89J RU https://pubmed.ncbi.nlm.nih.gov/21558436 DM5TYMG DI DM5TYMG DM5TYMG DN LY86057 DM5TYMG MI TTJQOD7 DM5TYMG MN 5-HT 2A receptor (HTR2A) DM5TYMG MT DTT DM5TYMG MA Antagonist DM5TYMG RN Species variations in transmembrane region V of the 5-hydroxytryptamine type 2A receptor alter the structure-activity relationship of certain ergolines and tryptamines. Mol Pharmacol. 1994 Feb;45(2):277-86. DM5TYMG RU https://pubmed.ncbi.nlm.nih.gov/8114677 DM5TYMG DI DM5TYMG DM5TYMG DN LY86057 DM5TYMG MI TT0K1SC DM5TYMG MN 5-HT 2B receptor (HTR2B) DM5TYMG MT DTT DM5TYMG MA Antagonist DM5TYMG RN Pharmacological characteristics of the newly cloned rat 5-hydroxytryptamine2F receptor. Mol Pharmacol. 1993 Mar;43(3):419-26. DM5TYMG RU https://pubmed.ncbi.nlm.nih.gov/8450835 DMTNVP4 DI DMTNVP4 DMTNVP4 DN LY97241 DMTNVP4 MI TT9XKUC DMTNVP4 MN Voltage-gated potassium channel Kv10.1 (KCNH1) DMTNVP4 MT DTT DMTNVP4 MA Blocker (channel blocker) DMTNVP4 RN Inhibition of hEAG1 and hERG1 potassium channels by clofilium and its tertiary analogue LY97241. Br J Pharmacol. 2003 Jan;138(1):161-71. DMTNVP4 RU https://pubmed.ncbi.nlm.nih.gov/12522086 DMTNVP4 DI DMTNVP4 DMTNVP4 DN LY97241 DMTNVP4 MI TTX8LQ0 DMTNVP4 MN Voltage-gated potassium channel Kv10.2 (KCNH5) DMTNVP4 MT DTT DMTNVP4 MA Blocker (channel blocker) DMTNVP4 RN Molecular determinants for high-affinity block of human EAG potassium channels by antiarrhythmic agents. Mol Pharmacol. 2004 May;65(5):1120-9. DMTNVP4 RU https://pubmed.ncbi.nlm.nih.gov/15102940 DMVX19Q DI DMVX19Q DMVX19Q DN LYCOGARUBIN B DMVX19Q MI TT1VAUK DMVX19Q MN VEGFR1 messenger RNA (VEGFR1 mRNA) DMVX19Q MT DTT DMVX19Q MA Inhibitor DMVX19Q RN New cytotoxic bisindole alkaloids with protein tyrosine kinase inhibitory activity from a myxomycete Lycogala epidendrum. Bioorg Med Chem Lett. 2005 Jun 2;15(11):2776-80. DMVX19Q RU https://pubmed.ncbi.nlm.nih.gov/15911254 DMH0Q9V DI DMH0Q9V DMH0Q9V DN Lys[Z(NO2)]-Lys[Z(NO2)] DMH0Q9V MI TT27Q3A DMH0Q9V MN Solute carrier family 15 member 2 (SLC15A2) DMH0Q9V MT DTT DMH0Q9V MA Inhibitor DMH0Q9V RN Defining minimal structural features in substrates of the H(+)/peptide cotransporter PEPT2 using novel amino acid and dipeptide derivatives. Mol Pharmacol. 2002 Jan;61(1):214-21. DMH0Q9V RU https://pubmed.ncbi.nlm.nih.gov/11752223 DMJX4GA DI DMJX4GA DMJX4GA DN Lys[Z(NO2)]-Pro DMJX4GA MI TT5LF3C DMJX4GA MN Solute carrier family 15 member 1 (SLC15A1) DMJX4GA MT DTT DMJX4GA MA Inhibitor DMJX4GA RN A novel inhibitor of the mammalian peptide transporter PEPT1. Biochemistry. 2001 Apr 10;40(14):4454-8. DMJX4GA RU https://pubmed.ncbi.nlm.nih.gov/11284702 DMJX4GA DI DMJX4GA DMJX4GA DN Lys[Z(NO2)]-Pro DMJX4GA MI TT27Q3A DMJX4GA MN Solute carrier family 15 member 2 (SLC15A2) DMJX4GA MT DTT DMJX4GA MA Inhibitor DMJX4GA RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 985). DMJX4GA RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=985 DM4MGAQ DI DM4MGAQ DM4MGAQ DN lysergic acid DM4MGAQ MI TT6MSOK DM4MGAQ MN 5-HT 1D receptor (HTR1D) DM4MGAQ MT DTT DM4MGAQ MA Agonist DM4MGAQ RN Alniditan, a new 5-hydroxytryptamine1D agonist and migraine-abortive agent: ligand-binding properties of human 5-hydroxytryptamine1D alpha, human 5-hydroxytryptamine1D beta, and calf 5-hydroxytryptamine1D receptors investigated with [3H]5-hydroxytryptamine and [3H]alniditan. Mol Pharmacol. 1996 Dec;50(6):1567-80. DM4MGAQ RU https://pubmed.ncbi.nlm.nih.gov/8967979 DM4MGAQ DI DM4MGAQ DM4MGAQ DN lysergic acid DM4MGAQ MI TTRUFDT DM4MGAQ MN 5-HT 5A receptor (HTR5A) DM4MGAQ MT DTT DM4MGAQ MA Agonist DM4MGAQ RN Expression of functional mouse 5-HT5A serotonin receptor in the methylotrophic yeast Pichia pastoris: pharmacological characterization and localization. FEBS Lett. 1995 Dec 27;377(3):451-6. DM4MGAQ RU https://pubmed.ncbi.nlm.nih.gov/8549774 DM1OHF8 DI DM1OHF8 DM1OHF8 DN lysergol DM1OHF8 MI TTK8CXU DM1OHF8 MN 5-HT 1B receptor (HTR1B) DM1OHF8 MT DTT DM1OHF8 MA Agonist DM1OHF8 RN Two amino acid differences in the sixth transmembrane domain are partially responsible for the pharmacological differences between the 5-HT1D beta and 5-HT1E 5-hydroxytryptamine receptors. J Neurochem. 1996 Nov;67(5):2096-103. DM1OHF8 RU https://pubmed.ncbi.nlm.nih.gov/8863519 DM1OHF8 DI DM1OHF8 DM1OHF8 DN lysergol DM1OHF8 MI TT6MSOK DM1OHF8 MN 5-HT 1D receptor (HTR1D) DM1OHF8 MT DTT DM1OHF8 MA Agonist DM1OHF8 RN Human serotonin 1D receptor is encoded by a subfamily of two distinct genes: 5-HT1D alpha and 5-HT1D beta. Proc Natl Acad Sci U S A. 1992 Apr 15;89(8):3630-4. DM1OHF8 RU https://pubmed.ncbi.nlm.nih.gov/1565658 DM1OHF8 DI DM1OHF8 DM1OHF8 DN lysergol DM1OHF8 MI TTCPG9S DM1OHF8 MN 5-HT 1E receptor (HTR1E) DM1OHF8 MT DTT DM1OHF8 MA Agonist DM1OHF8 RN Two amino acid differences in the sixth transmembrane domain are partially responsible for the pharmacological differences between the 5-HT1D beta and 5-HT1E 5-hydroxytryptamine receptors. J Neurochem. 1996 Nov;67(5):2096-103. DM1OHF8 RU https://pubmed.ncbi.nlm.nih.gov/8863519 DMIZQW6 DI DMIZQW6 DMIZQW6 DN LYSICAMINE DMIZQW6 MI TT1RS9F DMIZQW6 MN Acetylcholinesterase (AChE) DMIZQW6 MT DTT DMIZQW6 MA Inhibitor DMIZQW6 RN Characterization of Acetylcholinesterase Inhibitory Constituents from Annona glabra Assisted by HPLC Microfractionation. J Nat Prod. 2010 Oct 22;73(10):1632-5. DMIZQW6 RU https://pubmed.ncbi.nlm.nih.gov/20828184 DMW1YK3 DI DMW1YK3 DMW1YK3 DN Lysine Nz-Carboxylic Acid DMW1YK3 MI TT7HF4W DMW1YK3 MN Cyclin-dependent kinase 2 (CDK2) DMW1YK3 MT DTT DMW1YK3 MA Inhibitor DMW1YK3 RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMW1YK3 RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMW1YK3 DI DMW1YK3 DMW1YK3 DN Lysine Nz-Carboxylic Acid DMW1YK3 MI TT6TMZU DMW1YK3 MN Mycobacterium Biosynthetic alanine racemase (MycB alr) DMW1YK3 MT DTT DMW1YK3 MA Inhibitor DMW1YK3 RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMW1YK3 RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMW1YK3 DI DMW1YK3 DMW1YK3 DN Lysine Nz-Carboxylic Acid DMW1YK3 MI TT09NOX DMW1YK3 MN Plasmodium Dihydroorotase (Malaria dho) DMW1YK3 MT DTT DMW1YK3 MA Inhibitor DMW1YK3 RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMW1YK3 RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMOGFVH DI DMOGFVH DMOGFVH DN Lysophosphatidylcholine DMOGFVH MI DT5G94L DMOGFVH MN Major facilitator superfamily domain-containing protein 2A (SLC59A1) DMOGFVH MT DTP DMOGFVH MA Substrate DMOGFVH RN Mfsd2a is a transporter for the essential omega-3 fatty acid docosahexaenoic acid. Nature. 2014 May 22;509(7501):503-6. DMOGFVH RU http://www.ncbi.nlm.nih.gov/pubmed/24828044 DMOGFVH DI DMOGFVH DMOGFVH DN Lysophosphatidylcholine DMOGFVH MI TT32NQ1 DMOGFVH MN Short transient receptor potential channel 5 (TRPC5) DMOGFVH MT DTT DMOGFVH MA Activator DMOGFVH RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 490). DMOGFVH RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=490 DMOGFVH DI DMOGFVH DMOGFVH DN Lysophosphatidylcholine DMOGFVH MI TTRBT3W DMOGFVH MN Short transient receptor potential channel 6 (TRPC6) DMOGFVH MT DTT DMOGFVH MA Activator DMOGFVH RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 491). DMOGFVH RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=491 DMOGFVH DI DMOGFVH DMOGFVH DN Lysophosphatidylcholine DMOGFVH MI TTBECWA DMOGFVH MN Transient receptor potential cation channel V2 (TRPV2) DMOGFVH MT DTT DMOGFVH MA Activator DMOGFVH RN Lysophospholipids stimulate prostate cancer cell migration via TRPV2 channel activation. Biochim Biophys Acta. 2009 Mar;1793(3):528-39. DMOGFVH RU https://pubmed.ncbi.nlm.nih.gov/19321128 DMI4FKH DI DMI4FKH DMI4FKH DN lysophosphatidylethanolamine DMI4FKH MI TT7QNVC DMI4FKH MN Glucose-dependent insulinotropic receptor (GPR119) DMI4FKH MT DTT DMI4FKH MA Agonist DMI4FKH RN Lysophosphatidylcholine enhances glucose-dependent insulin secretion via an orphan G-protein-coupled receptor. Biochem Biophys Res Commun. 2005 Jan 28;326(4):744-51. DMI4FKH RU https://pubmed.ncbi.nlm.nih.gov/15607732 DMETM3R DI DMETM3R DMETM3R DN lysophosphatidylinositol DMETM3R MI TT7QNVC DMETM3R MN Glucose-dependent insulinotropic receptor (GPR119) DMETM3R MT DTT DMETM3R MA Agonist DMETM3R RN Lysophosphatidylcholine enhances glucose-dependent insulin secretion via an orphan G-protein-coupled receptor. Biochem Biophys Res Commun. 2005 Jan 28;326(4):744-51. DMETM3R RU https://pubmed.ncbi.nlm.nih.gov/15607732 DMETM3R DI DMETM3R DMETM3R DN lysophosphatidylinositol DMETM3R MI TTNET8J DMETM3R MN G-protein coupled receptor 55 (GPR55) DMETM3R MT DTT DMETM3R MA Agonist DMETM3R RN Screening beta-arrestin recruitment for the identification of natural ligands for orphan G-protein-coupled receptors. J Biomol Screen. 2013 Jun;18(5):599-609. DMETM3R RU https://pubmed.ncbi.nlm.nih.gov/23396314 DMETM3R DI DMETM3R DMETM3R DN lysophosphatidylinositol DMETM3R MI TTBECWA DMETM3R MN Transient receptor potential cation channel V2 (TRPV2) DMETM3R MT DTT DMETM3R MA Activator DMETM3R RN Lysophospholipids stimulate prostate cancer cell migration via TRPV2 channel activation. Biochim Biophys Acta. 2009 Mar;1793(3):528-39. DMETM3R RU https://pubmed.ncbi.nlm.nih.gov/19321128 DMKG7J2 DI DMKG7J2 DMKG7J2 DN lysophosphatidylserine DMKG7J2 MI TTYUB4M DMKG7J2 MN G-protein coupled receptor 174 (GPR174) DMKG7J2 MT DTT DMKG7J2 MA Agonist DMKG7J2 RN TGFalpha shedding assay: an accurate and versatile method for detecting GPCR activation. Nat Methods. 2012 Oct;9(10):1021-9. DMKG7J2 RU https://pubmed.ncbi.nlm.nih.gov/22983457 DMKG7J2 DI DMKG7J2 DMKG7J2 DN lysophosphatidylserine DMKG7J2 MI TTVXSTQ DMKG7J2 MN G-protein coupled receptor 34 (GPR34) DMKG7J2 MT DTT DMKG7J2 MA Agonist DMKG7J2 RN GPR34 is a receptor for lysophosphatidylserine with a fatty acid at the sn-2 position. J Biochem. 2012 May;151(5):511-8. DMKG7J2 RU https://pubmed.ncbi.nlm.nih.gov/22343749 DMIG3FX DI DMIG3FX DMIG3FX DN Lysophosphotidylserine DMIG3FX MI TT6L509 DMIG3FX MN Coagulation factor IIa (F2) DMIG3FX MT DTT DMIG3FX MA Inhibitor DMIG3FX RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMIG3FX RU https://pubmed.ncbi.nlm.nih.gov/17139284 DME15MN DI DME15MN DME15MN DN Lys-thiol DME15MN MI TTD74YX DME15MN MN Arginyl aminopeptidase (RNPEP) DME15MN MT DTT DME15MN MA Inhibitor DME15MN RN L-lysinethiol: a subnanomolar inhibitor of aminopeptidase B. Biochem Biophys Res Commun. 1987 Jun 30;145(3):1038-42. DME15MN RU https://pubmed.ncbi.nlm.nih.gov/3111463 DMJQG82 DI DMJQG82 DMJQG82 DN M&B 28767 DMJQG82 MI TTG1QMU DMJQG82 MN Prostaglandin E2 receptor EP1 (PTGER1) DMJQG82 MT DTT DMJQG82 MA Agonist DMJQG82 RN Ligand binding specificities of the eight types and subtypes of the mouse prostanoid receptors expressed in Chinese hamster ovary cells. Br J Pharmacol. 1997 Sep;122(2):217-24. DMJQG82 RU https://pubmed.ncbi.nlm.nih.gov/9313928 DMJQG82 DI DMJQG82 DMJQG82 DN M&B 28767 DMJQG82 MI TT1ZAVI DMJQG82 MN Prostaglandin E2 receptor EP2 (PTGER2) DMJQG82 MT DTT DMJQG82 MA Agonist DMJQG82 RN Molecular cloning and characterization of the four rat prostaglandin E2 prostanoid receptor subtypes. Eur J Pharmacol. 1997 Dec 11;340(2-3):227-41. DMJQG82 RU https://pubmed.ncbi.nlm.nih.gov/9537820 DMJQG82 DI DMJQG82 DMJQG82 DN M&B 28767 DMJQG82 MI TTPNGDE DMJQG82 MN Prostaglandin E2 receptor EP3 (PTGER3) DMJQG82 MT DTT DMJQG82 MA Agonist DMJQG82 RN Ligand binding specificities of the eight types and subtypes of the mouse prostanoid receptors expressed in Chinese hamster ovary cells. Br J Pharmacol. 1997 Sep;122(2):217-24. DMJQG82 RU https://pubmed.ncbi.nlm.nih.gov/9313928 DMJQG82 DI DMJQG82 DMJQG82 DN M&B 28767 DMJQG82 MI TT79WV3 DMJQG82 MN Prostaglandin E2 receptor EP4 (PTGER4) DMJQG82 MT DTT DMJQG82 MA Agonist DMJQG82 RN Ligand binding specificities of the eight types and subtypes of the mouse prostanoid receptors expressed in Chinese hamster ovary cells. Br J Pharmacol. 1997 Sep;122(2):217-24. DMJQG82 RU https://pubmed.ncbi.nlm.nih.gov/9313928 DMJQG82 DI DMJQG82 DMJQG82 DN M&B 28767 DMJQG82 MI TTT2ZAR DMJQG82 MN Prostaglandin F2-alpha receptor (PTGFR) DMJQG82 MT DTT DMJQG82 MA Agonist DMJQG82 RN Ligand binding specificities of the eight types and subtypes of the mouse prostanoid receptors expressed in Chinese hamster ovary cells. Br J Pharmacol. 1997 Sep;122(2):217-24. DMJQG82 RU https://pubmed.ncbi.nlm.nih.gov/9313928 DMJQG82 DI DMJQG82 DMJQG82 DN M&B 28767 DMJQG82 MI TT2O84V DMJQG82 MN Thromboxane A2 receptor (TBXA2R) DMJQG82 MT DTT DMJQG82 MA Agonist DMJQG82 RN The utilization of recombinant prostanoid receptors to determine the affinities and selectivities of prostaglandins and related analogs. Biochim Biophys Acta. 2000 Jan 17;1483(2):285-93. DMJQG82 RU https://pubmed.ncbi.nlm.nih.gov/10634944 DMYU3Z7 DI DMYU3Z7 DMYU3Z7 DN M372049 DMYU3Z7 MI TTWVLS6 DMYU3Z7 MN Natriuretic peptide receptor (NPR3) DMYU3Z7 MT DTT DMYU3Z7 MA Antagonist DMYU3Z7 RN Natriuretic peptide receptor-C regulates coronary blood flow and prevents myocardial ischemia/reperfusion injury: novel cardioprotective role for e... Circulation. 2004 Sep 7;110(10):1231-5. DMYU3Z7 RU https://pubmed.ncbi.nlm.nih.gov/15337698 DMJK1RE DI DMJK1RE DMJK1RE DN M3A6S DMJK1RE MI TTQW87Y DMJK1RE MN Opioid receptor kappa (OPRK1) DMJK1RE MT DTT DMJK1RE MA Inhibitor DMJK1RE RN Opiate receptor binding properties of morphine-, dihydromorphine-, and codeine 6-O-sulfate ester congeners. Bioorg Med Chem Lett. 2006 Aug 15;16(16):4291-5. DMJK1RE RU https://pubmed.ncbi.nlm.nih.gov/16777416 DMJK1RE DI DMJK1RE DMJK1RE DN M3A6S DMJK1RE MI TTKWM86 DMJK1RE MN Opioid receptor mu (MOP) DMJK1RE MT DTT DMJK1RE MA Inhibitor DMJK1RE RN Opiate receptor binding properties of morphine-, dihydromorphine-, and codeine 6-O-sulfate ester congeners. Bioorg Med Chem Lett. 2006 Aug 15;16(16):4291-5. DMJK1RE RU https://pubmed.ncbi.nlm.nih.gov/16777416 DMAHGBF DI DMAHGBF DMAHGBF DN M3B6S DMAHGBF MI TTKWM86 DMAHGBF MN Opioid receptor mu (MOP) DMAHGBF MT DTT DMAHGBF MA Inhibitor DMAHGBF RN Opiate receptor binding properties of morphine-, dihydromorphine-, and codeine 6-O-sulfate ester congeners. Bioorg Med Chem Lett. 2006 Aug 15;16(16):4291-5. DMAHGBF RU https://pubmed.ncbi.nlm.nih.gov/16777416 DM0UOF1 DI DM0UOF1 DM0UOF1 DN M3IBu6S DM0UOF1 MI TTQW87Y DM0UOF1 MN Opioid receptor kappa (OPRK1) DM0UOF1 MT DTT DM0UOF1 MA Inhibitor DM0UOF1 RN Opiate receptor binding properties of morphine-, dihydromorphine-, and codeine 6-O-sulfate ester congeners. Bioorg Med Chem Lett. 2006 Aug 15;16(16):4291-5. DM0UOF1 RU https://pubmed.ncbi.nlm.nih.gov/16777416 DM0UOF1 DI DM0UOF1 DM0UOF1 DN M3IBu6S DM0UOF1 MI TTKWM86 DM0UOF1 MN Opioid receptor mu (MOP) DM0UOF1 MT DTT DM0UOF1 MA Inhibitor DM0UOF1 RN Opiate receptor binding properties of morphine-, dihydromorphine-, and codeine 6-O-sulfate ester congeners. Bioorg Med Chem Lett. 2006 Aug 15;16(16):4291-5. DM0UOF1 RU https://pubmed.ncbi.nlm.nih.gov/16777416 DMXT87E DI DMXT87E DMXT87E DN M3P6S DMXT87E MI TTQW87Y DMXT87E MN Opioid receptor kappa (OPRK1) DMXT87E MT DTT DMXT87E MA Inhibitor DMXT87E RN Opiate receptor binding properties of morphine-, dihydromorphine-, and codeine 6-O-sulfate ester congeners. Bioorg Med Chem Lett. 2006 Aug 15;16(16):4291-5. DMXT87E RU https://pubmed.ncbi.nlm.nih.gov/16777416 DMXT87E DI DMXT87E DMXT87E DN M3P6S DMXT87E MI TTKWM86 DMXT87E MN Opioid receptor mu (MOP) DMXT87E MT DTT DMXT87E MA Inhibitor DMXT87E RN Opiate receptor binding properties of morphine-, dihydromorphine-, and codeine 6-O-sulfate ester congeners. Bioorg Med Chem Lett. 2006 Aug 15;16(16):4291-5. DMXT87E RU https://pubmed.ncbi.nlm.nih.gov/16777416 DMMC8RN DI DMMC8RN DMMC8RN DN M3Pr6S DMMC8RN MI TTQW87Y DMMC8RN MN Opioid receptor kappa (OPRK1) DMMC8RN MT DTT DMMC8RN MA Inhibitor DMMC8RN RN Opiate receptor binding properties of morphine-, dihydromorphine-, and codeine 6-O-sulfate ester congeners. Bioorg Med Chem Lett. 2006 Aug 15;16(16):4291-5. DMMC8RN RU https://pubmed.ncbi.nlm.nih.gov/16777416 DMMC8RN DI DMMC8RN DMMC8RN DN M3Pr6S DMMC8RN MI TTKWM86 DMMC8RN MN Opioid receptor mu (MOP) DMMC8RN MT DTT DMMC8RN MA Inhibitor DMMC8RN RN Opiate receptor binding properties of morphine-, dihydromorphine-, and codeine 6-O-sulfate ester congeners. Bioorg Med Chem Lett. 2006 Aug 15;16(16):4291-5. DMMC8RN RU https://pubmed.ncbi.nlm.nih.gov/16777416 DMWADOY DI DMWADOY DMWADOY DN M3S DMWADOY MI TTKWM86 DMWADOY MN Opioid receptor mu (MOP) DMWADOY MT DTT DMWADOY MA Inhibitor DMWADOY RN Opiate receptor binding properties of morphine-, dihydromorphine-, and codeine 6-O-sulfate ester congeners. Bioorg Med Chem Lett. 2006 Aug 15;16(16):4291-5. DMWADOY RU https://pubmed.ncbi.nlm.nih.gov/16777416 DM3IX2E DI DM3IX2E DM3IX2E DN M5 DM3IX2E MI TTP86E2 DM3IX2E MN Plasminogen (PLG) DM3IX2E MT DTT DM3IX2E MA Activator DM3IX2E RN Tranexamic acid in trauma: how should we use it. J Trauma Acute Care Surg. 2013 Jun;74(6):1575-86. DM3IX2E RU https://pubmed.ncbi.nlm.nih.gov/23694890 DMM5X8Z DI DMM5X8Z DMM5X8Z DN M55113 DMM5X8Z MI TTCIHJA DMM5X8Z MN Coagulation factor Xa (F10) DMM5X8Z MT DTT DMM5X8Z MA Inhibitor DMM5X8Z RN Synthesis and evaluation of 1-arylsulfonyl-3-piperazinone derivatives as factor Xa inhibitor. Chem Pharm Bull (Tokyo). 2001 Oct;49(10):1237-44. DMM5X8Z RU https://pubmed.ncbi.nlm.nih.gov/11605647 DMFS7QK DI DMFS7QK DMFS7QK DN M-5MPEP DMFS7QK MI TTHS256 DMFS7QK MN Metabotropic glutamate receptor 5 (mGluR5) DMFS7QK MT DTT DMFS7QK MA Modulator (allosteric modulator) DMFS7QK RN A close structural analog of 2-methyl-6-(phenylethynyl)-pyridine acts as a neutral allosteric site ligand on metabotropic glutamate receptor subtyp... Mol Pharmacol. 2005 Dec;68(6):1793-802. DMFS7QK RU https://pubmed.ncbi.nlm.nih.gov/16155210 DMRB4YV DI DMRB4YV DMRB4YV DN M6G thiosaccharide analogue DMRB4YV MI TT27RFC DMRB4YV MN Opioid receptor delta (OPRD1) DMRB4YV MT DTT DMRB4YV MA Inhibitor DMRB4YV RN Synthesis and in vitro biological evaluation of a carbon glycoside analogue of morphine-6-glucuronide. Bioorg Med Chem Lett. 2005 Mar 15;15(6):1583-6. DMRB4YV RU https://pubmed.ncbi.nlm.nih.gov/15745801 DMRB4YV DI DMRB4YV DMRB4YV DN M6G thiosaccharide analogue DMRB4YV MI TTQW87Y DMRB4YV MN Opioid receptor kappa (OPRK1) DMRB4YV MT DTT DMRB4YV MA Inhibitor DMRB4YV RN Synthesis and in vitro biological evaluation of a carbon glycoside analogue of morphine-6-glucuronide. Bioorg Med Chem Lett. 2005 Mar 15;15(6):1583-6. DMRB4YV RU https://pubmed.ncbi.nlm.nih.gov/15745801 DMRB4YV DI DMRB4YV DMRB4YV DN M6G thiosaccharide analogue DMRB4YV MI TTKWM86 DMRB4YV MN Opioid receptor mu (MOP) DMRB4YV MT DTT DMRB4YV MA Inhibitor DMRB4YV RN Synthesis and in vitro biological evaluation of a carbon glycoside analogue of morphine-6-glucuronide. Bioorg Med Chem Lett. 2005 Mar 15;15(6):1583-6. DMRB4YV RU https://pubmed.ncbi.nlm.nih.gov/15745801 DMFCUN4 DI DMFCUN4 DMFCUN4 DN M6S DMFCUN4 MI TTQW87Y DMFCUN4 MN Opioid receptor kappa (OPRK1) DMFCUN4 MT DTT DMFCUN4 MA Inhibitor DMFCUN4 RN Opiate receptor binding properties of morphine-, dihydromorphine-, and codeine 6-O-sulfate ester congeners. Bioorg Med Chem Lett. 2006 Aug 15;16(16):4291-5. DMFCUN4 RU https://pubmed.ncbi.nlm.nih.gov/16777416 DMFCUN4 DI DMFCUN4 DMFCUN4 DN M6S DMFCUN4 MI TTKWM86 DMFCUN4 MN Opioid receptor mu (MOP) DMFCUN4 MT DTT DMFCUN4 MA Inhibitor DMFCUN4 RN Opiate receptor binding properties of morphine-, dihydromorphine-, and codeine 6-O-sulfate ester congeners. Bioorg Med Chem Lett. 2006 Aug 15;16(16):4291-5. DMFCUN4 RU https://pubmed.ncbi.nlm.nih.gov/16777416 DM9NPE4 DI DM9NPE4 DM9NPE4 DN M826 DM9NPE4 MI TTCQIBE DM9NPE4 MN Caspase-1 (CASP1) DM9NPE4 MT DTT DM9NPE4 MA Inhibitor DM9NPE4 RN Novel pyrazinone mono-amides as potent and reversible caspase-3 inhibitors. Bioorg Med Chem Lett. 2005 Feb 15;15(4):1173-80. DM9NPE4 RU https://pubmed.ncbi.nlm.nih.gov/15686936 DM9NPE4 DI DM9NPE4 DM9NPE4 DN M826 DM9NPE4 MI TTPF2QI DM9NPE4 MN Caspase-3 (CASP3) DM9NPE4 MT DTT DM9NPE4 MA Inhibitor DM9NPE4 RN Novel pyrazinone mono-amides as potent and reversible caspase-3 inhibitors. Bioorg Med Chem Lett. 2005 Feb 15;15(4):1173-80. DM9NPE4 RU https://pubmed.ncbi.nlm.nih.gov/15686936 DM9NPE4 DI DM9NPE4 DM9NPE4 DN M826 DM9NPE4 MI TT3VZ8D DM9NPE4 MN Caspase-4 (CASP4) DM9NPE4 MT DTT DM9NPE4 MA Inhibitor DM9NPE4 RN Novel pyrazinone mono-amides as potent and reversible caspase-3 inhibitors. Bioorg Med Chem Lett. 2005 Feb 15;15(4):1173-80. DM9NPE4 RU https://pubmed.ncbi.nlm.nih.gov/15686936 DM9NPE4 DI DM9NPE4 DM9NPE4 DN M826 DM9NPE4 MI TTWR48J DM9NPE4 MN Caspase-5 (CASP5) DM9NPE4 MT DTT DM9NPE4 MA Inhibitor DM9NPE4 RN Novel pyrazinone mono-amides as potent and reversible caspase-3 inhibitors. Bioorg Med Chem Lett. 2005 Feb 15;15(4):1173-80. DM9NPE4 RU https://pubmed.ncbi.nlm.nih.gov/15686936 DM9NPE4 DI DM9NPE4 DM9NPE4 DN M826 DM9NPE4 MI TTM7Y45 DM9NPE4 MN Caspase-7 (CASP7) DM9NPE4 MT DTT DM9NPE4 MA Inhibitor DM9NPE4 RN Novel pyrazinone mono-amides as potent and reversible caspase-3 inhibitors. Bioorg Med Chem Lett. 2005 Feb 15;15(4):1173-80. DM9NPE4 RU https://pubmed.ncbi.nlm.nih.gov/15686936 DM8I0TY DI DM8I0TY DM8I0TY DN M8-B DM8I0TY MI TTXDKTO DM8I0TY MN Long transient receptor potential channel 8 (TRPM8) DM8I0TY MT DTT DM8I0TY MA Blocker (channel blocker) DM8I0TY RN Pharmacological blockade of the cold receptor TRPM8 attenuates autonomic and behavioral cold defenses and decreases deep body temperature. J Neurosci. 2012 Feb 8;32(6):2086-99. DM8I0TY RU https://pubmed.ncbi.nlm.nih.gov/22323721 DMKWQ52 DI DMKWQ52 DMKWQ52 DN MA-2029 DMKWQ52 MI TT953CX DMKWQ52 MN Motilin receptor (MLNR) DMKWQ52 MT DTT DMKWQ52 MA Antagonist DMKWQ52 RN Oral administration of MA-2029, a novel selective and competitive motilin receptor antagonist, inhibits motilin-induced intestinal contractions and visceral pain in rabbits. Eur J Pharmacol. 2008 Mar10;581(3):296-305. DMKWQ52 RU https://pubmed.ncbi.nlm.nih.gov/18164286 DMDHGM2 DI DMDHGM2 DMDHGM2 DN Maackiain DMDHGM2 MI TTF8JAT DMDHGM2 MN SLC5A2 messenger RNA (SLC5A2 mRNA) DMDHGM2 MT DTT DMDHGM2 MA Inhibitor DMDHGM2 RN Na+-glucose cotransporter (SGLT) inhibitory flavonoids from the roots of Sophora flavescens. Bioorg Med Chem. 2007 May 15;15(10):3445-9. DMDHGM2 RU https://pubmed.ncbi.nlm.nih.gov/17374486 DM1ICOW DI DM1ICOW DM1ICOW DN mab 224G11 DM1ICOW MI TTNDSF4 DM1ICOW MN Proto-oncogene c-Met (MET) DM1ICOW MT DTT DM1ICOW RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1815). DM1ICOW RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1815 DMJX2CS DI DMJX2CS DMJX2CS DN mabionHER2 DMJX2CS MI TTGKNB4 DMJX2CS MN Epidermal growth factor receptor (EGFR) DMJX2CS MT DTT DMJX2CS RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1797). DMJX2CS RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1797 DMDLF0J DI DMDLF0J DMDLF0J DN Macbecin DMDLF0J MI TT78R5H DMDLF0J MN Heat shock protein 90 alpha (HSP90A) DMDLF0J MT DTT DMDLF0J MA Inhibitor DMDLF0J RN Recent advances in Hsp90 inhibitors as antitumor agents. Anticancer Agents Med Chem. 2008 Oct;8(7):761-82. DMDLF0J RU https://pubmed.ncbi.nlm.nih.gov/18855578 DMOMG7S DI DMOMG7S DMOMG7S DN MACLURAXANTHONE DMOMG7S MI TT50QJ3 DMOMG7S MN Influenza Neuraminidase (Influ NA) DMOMG7S MT DTT DMOMG7S MA Inhibitor DMOMG7S RN Characteristic of neuraminidase inhibitory xanthones from Cudrania tricuspidata. Bioorg Med Chem. 2009 Apr 1;17(7):2744-50. DMOMG7S RU https://pubmed.ncbi.nlm.nih.gov/19285413 DMFULZO DI DMFULZO DMFULZO DN Macrocyclic tripeptide motif DMFULZO MI TT2WR1T DMFULZO MN Cationic trypsinogen (PRSS1) DMFULZO MT DTT DMFULZO MA Inhibitor DMFULZO RN Novel thrombin inhibitors that are based on a macrocyclic tripeptide motif, Bioorg. Med. Chem. Lett. 6(24):2947-2952 (1996). DMFULZO RU http://www.sciencedirect.com/science/article/pii/S0960894X96005549 DMFULZO DI DMFULZO DMFULZO DN Macrocyclic tripeptide motif DMFULZO MI TT6L509 DMFULZO MN Coagulation factor IIa (F2) DMFULZO MT DTT DMFULZO MA Inhibitor DMFULZO RN Novel thrombin inhibitors that are based on a macrocyclic tripeptide motif, Bioorg. Med. Chem. Lett. 6(24):2947-2952 (1996). DMFULZO RU http://www.sciencedirect.com/science/article/pii/S0960894X96005549 DMSQL19 DI DMSQL19 DMSQL19 DN MAGGIEMYCIN DMSQL19 MI TTSJ542 DMSQL19 MN Integrin alpha-2 (ITGA2) DMSQL19 MT DTT DMSQL19 MA Inhibitor DMSQL19 RN Small molecule designed to target metal binding site in the alpha2I domain inhibits integrin function. J Med Chem. 2007 May 31;50(11):2742-6. DMSQL19 RU https://pubmed.ncbi.nlm.nih.gov/17447751 DM5WNH8 DI DM5WNH8 DM5WNH8 DN Mahureone D DM5WNH8 MI TTIU7X1 DM5WNH8 MN Herpes simplex virus DNA polymerase UL30 (HSV UL30) DM5WNH8 MT DTT DM5WNH8 MA Inhibitor DM5WNH8 RN Acylphloroglucinol derivatives from Mahurea palustris. J Nat Prod. 2005 Jul;68(7):979-84. DM5WNH8 RU https://pubmed.ncbi.nlm.nih.gov/16038535 DMKE03Q DI DMKE03Q DMKE03Q DN Makaluvamine N DMKE03Q MI TT0IHXV DMKE03Q MN DNA topoisomerase II (TOP2) DMKE03Q MT DTT DMKE03Q MA Inhibitor DMKE03Q RN Makaluvamine N: a new pyrroloiminoquinone from Zyzzya fuliginosa. J Nat Prod. 1997 Apr;60(4):408-10. DMKE03Q RU https://pubmed.ncbi.nlm.nih.gov/9134749 DMMCJLH DI DMMCJLH DMMCJLH DN Malate DMMCJLH MI DEIRBUF DMMCJLH MN L-malate:NADP(+) oxidoreductase (maeB) DMMCJLH MT DME DMMCJLH MA Metabolism DMMCJLH RN nan DMMCJLH RU nan DMMCJLH DI DMMCJLH DMMCJLH DN Malate DMMCJLH MI DE97WM8 DMMCJLH MN NADP-dependent malic enzyme (ME1) DMMCJLH MT DME DMMCJLH MA Metabolism DMMCJLH RN Structural characteristics of the nonallosteric human cytosolic malic enzyme. Biochim Biophys Acta. 2014 Oct;1844(10):1773-83. DMMCJLH RU https://www.ncbi.nlm.nih.gov/pubmed/?term=24998673 DM4OQWZ DI DM4OQWZ DM4OQWZ DN Malate Like Intermediate DM4OQWZ MI TTHDSE2 DM4OQWZ MN Bacterial Fumarate reductase flavoprotein (Bact frdA) DM4OQWZ MT DTT DM4OQWZ MA Inhibitor DM4OQWZ RN DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Nucleic Acids Res. 2011 Jan;39(Database issue):D1035-41. DM4OQWZ RU https://pubmed.ncbi.nlm.nih.gov/21059682 DM4L0R7 DI DM4L0R7 DM4L0R7 DN Maleic Acid DM4L0R7 MI TTU507L DM4L0R7 MN Cytoplasmic aspartate aminotransferase (GOT1) DM4L0R7 MT DTT DM4L0R7 MA Inhibitor DM4L0R7 RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DM4L0R7 RU https://pubmed.ncbi.nlm.nih.gov/10592235 DM4L0R7 DI DM4L0R7 DM4L0R7 DN Maleic Acid DM4L0R7 MI TTRTKPV DM4L0R7 MN Trypanosoma Trypanothione reductase (Trypano TPR) DM4L0R7 MT DTT DM4L0R7 MA Inhibitor DM4L0R7 RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DM4L0R7 RU https://pubmed.ncbi.nlm.nih.gov/10592235 DMU3O5H DI DMU3O5H DMU3O5H DN malic acid DMU3O5H MI TTAHD89 DMU3O5H MN Polycystic kidney disease 2-like 1 (TRPP2) DMU3O5H MT DTT DMU3O5H MA Activator DMU3O5H RN Transient receptor potential family members PKD1L3 and PKD2L1 form a candidate sour taste receptor. Proc Natl Acad Sci U S A. 2006 Aug 15;103(33):12569-74. DMU3O5H RU https://pubmed.ncbi.nlm.nih.gov/16891422 DM9ECWN DI DM9ECWN DM9ECWN DN Mallotinic acid DM9ECWN MI TTE14XG DM9ECWN MN Squalene monooxygenase (SQLE) DM9ECWN MT DTT DM9ECWN MA Inhibitor DM9ECWN RN Ellagitannins and hexahydroxydiphenoyl esters as inhibitors of vertebrate squalene epoxidase. J Nat Prod. 2001 Aug;64(8):1010-4. DM9ECWN RU https://pubmed.ncbi.nlm.nih.gov/11520216 DMHX9P8 DI DMHX9P8 DMHX9P8 DN Mallotusinic acid DMHX9P8 MI TTE14XG DMHX9P8 MN Squalene monooxygenase (SQLE) DMHX9P8 MT DTT DMHX9P8 MA Inhibitor DMHX9P8 RN Ellagitannins and hexahydroxydiphenoyl esters as inhibitors of vertebrate squalene epoxidase. J Nat Prod. 2001 Aug;64(8):1010-4. DMHX9P8 RU https://pubmed.ncbi.nlm.nih.gov/11520216 DMAJDU7 DI DMAJDU7 DMAJDU7 DN Malonate sodium DMAJDU7 MI TTZHA0O DMAJDU7 MN Carbonic anhydrase IV (CA-IV) DMAJDU7 MT DTT DMAJDU7 MA Inhibitor DMAJDU7 RN Carbonic anhydrase inhibitors. Interaction of isozymes I, II, IV, V, and IX with carboxylates. Bioorg Med Chem Lett. 2005 Feb 1;15(3):573-8. DMAJDU7 RU https://pubmed.ncbi.nlm.nih.gov/15664815 DMM5QXL DI DMM5QXL DMM5QXL DN Malonic acid DMM5QXL MI TTZFUY6 DMM5QXL MN Serine Racemase (SRR) DMM5QXL MT DTT DMM5QXL MA Inhibitor DMM5QXL RN Inhibition of human serine racemase, an emerging target for medicinal chemistry. Curr Drug Targets. 2011 Jun;12(7):1037-55. DMM5QXL RU https://pubmed.ncbi.nlm.nih.gov/21291385 DMMY542 DI DMMY542 DMMY542 DN Maltosyl-Alpha (1,4)-D-Gluconhydroximo-1,5-Lactam DMMY542 MI TTCGSZ4 DMMY542 MN Pancreatic alpha-amylase (AMY2A) DMMY542 MT DTT DMMY542 MA Inhibitor DMMY542 RN DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Nucleic Acids Res. 2011 Jan;39(Database issue):D1035-41. DMMY542 RU https://pubmed.ncbi.nlm.nih.gov/21059682 DM213MD DI DM213MD DM213MD DN M-Aminophenylboronic Acid DM213MD MI TTHI19T DM213MD MN Staphylococcus Beta-lactamase (Stap-coc blaZ) DM213MD MT DTT DM213MD MA Inhibitor DM213MD RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DM213MD RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMNUA6S DI DMNUA6S DMNUA6S DN Man-b-4MU DMNUA6S MI DE12T80 DMNUA6S MN Beta-mannosidase (manB) DMNUA6S MT DME DMNUA6S MA Metabolism DMNUA6S RN Structure and function of Bs164 beta-mannosidase from Bacteroides salyersiae the founding member of glycoside hydrolase family GH164. J Biol Chem. 2020 Mar 27;295(13):4316-4326. DMNUA6S RU https://pubmed.ncbi.nlm.nih.gov/31871050 DMKT129 DI DMKT129 DMKT129 DN Manganese DMKT129 MI DTVKMHD DMKT129 MN Natural resistance-associated macrophage protein 2 (SLC11A2) DMKT129 MT DTP DMKT129 MA Substrate DMKT129 RN Transmembrane topology of the mammalian Slc11a2 iron transporter. Biochemistry. 2009 Sep 8;48(35):8422-34. DMKT129 RU http://www.ncbi.nlm.nih.gov/pubmed/19621945 DMWAF5Z DI DMWAF5Z DMWAF5Z DN MANGIFERIN DMWAF5Z MI TTFBNVI DMWAF5Z MN Aldose reductase (AKR1B1) DMWAF5Z MT DTT DMWAF5Z MA Inhibitor DMWAF5Z RN Structures of new friedelane-type triterpenes and eudesmane-type sesquiterpene and aldose reductase inhibitors from Salacia chinensis. J Nat Prod. 2003 Sep;66(9):1191-6. DMWAF5Z RU https://pubmed.ncbi.nlm.nih.gov/14510595 DMWAF5Z DI DMWAF5Z DMWAF5Z DN MANGIFERIN DMWAF5Z MI TT50QJ3 DMWAF5Z MN Influenza Neuraminidase (Influ NA) DMWAF5Z MT DTT DMWAF5Z MA Inhibitor DMWAF5Z RN Characteristic of neuraminidase inhibitory xanthones from Cudrania tricuspidata. Bioorg Med Chem. 2009 Apr 1;17(7):2744-50. DMWAF5Z RU https://pubmed.ncbi.nlm.nih.gov/19285413 DMOWZUB DI DMOWZUB DMOWZUB DN MANGOSTANIN DMOWZUB MI TT50QJ3 DMOWZUB MN Influenza Neuraminidase (Influ NA) DMOWZUB MT DTT DMOWZUB MA Inhibitor DMOWZUB RN Xanthones with neuraminidase inhibitory activity from the seedcases of Garcinia mangostana. Bioorg Med Chem. 2010 Sep 1;18(17):6258-64. DMOWZUB RU https://pubmed.ncbi.nlm.nih.gov/20696581 DMG3DUE DI DMG3DUE DMG3DUE DN MANGOSTANOL DMG3DUE MI TT50QJ3 DMG3DUE MN Influenza Neuraminidase (Influ NA) DMG3DUE MT DTT DMG3DUE MA Inhibitor DMG3DUE RN Xanthones with neuraminidase inhibitory activity from the seedcases of Garcinia mangostana. Bioorg Med Chem. 2010 Sep 1;18(17):6258-64. DMG3DUE RU https://pubmed.ncbi.nlm.nih.gov/20696581 DMNRZ3S DI DMNRZ3S DMNRZ3S DN MANGOSTENONE F DMNRZ3S MI TT50QJ3 DMNRZ3S MN Influenza Neuraminidase (Influ NA) DMNRZ3S MT DTT DMNRZ3S MA Inhibitor DMNRZ3S RN Xanthones with neuraminidase inhibitory activity from the seedcases of Garcinia mangostana. Bioorg Med Chem. 2010 Sep 1;18(17):6258-64. DMNRZ3S RU https://pubmed.ncbi.nlm.nih.gov/20696581 DM4I2NR DI DM4I2NR DM4I2NR DN MANGOSTENONE G DM4I2NR MI TT50QJ3 DM4I2NR MN Influenza Neuraminidase (Influ NA) DM4I2NR MT DTT DM4I2NR MA Inhibitor DM4I2NR RN Xanthones with neuraminidase inhibitory activity from the seedcases of Garcinia mangostana. Bioorg Med Chem. 2010 Sep 1;18(17):6258-64. DM4I2NR RU https://pubmed.ncbi.nlm.nih.gov/20696581 DMYQGDV DI DMYQGDV DMYQGDV DN MANGOSTIN DMYQGDV MI TT12ABZ DMYQGDV MN Arachidonate 12-lipoxygenase (12-LOX) DMYQGDV MT DTT DMYQGDV MA Inhibitor DMYQGDV RN Discovery of platelet-type 12-human lipoxygenase selective inhibitors by high-throughput screening of structurally diverse libraries. Bioorg Med Chem. 2007 Nov 15;15(22):6900-8. DMYQGDV RU https://pubmed.ncbi.nlm.nih.gov/17826100 DMYQGDV DI DMYQGDV DMYQGDV DN MANGOSTIN DMYQGDV MI TTN9T81 DMYQGDV MN Arachidonate 15-lipoxygenase (15-LOX) DMYQGDV MT DTT DMYQGDV MA Inhibitor DMYQGDV RN Discovery of platelet-type 12-human lipoxygenase selective inhibitors by high-throughput screening of structurally diverse libraries. Bioorg Med Chem. 2007 Nov 15;15(22):6900-8. DMYQGDV RU https://pubmed.ncbi.nlm.nih.gov/17826100 DMYQGDV DI DMYQGDV DMYQGDV DN MANGOSTIN DMYQGDV MI TT50QJ3 DMYQGDV MN Influenza Neuraminidase (Influ NA) DMYQGDV MT DTT DMYQGDV MA Inhibitor DMYQGDV RN Xanthones with neuraminidase inhibitory activity from the seedcases of Garcinia mangostana. Bioorg Med Chem. 2010 Sep 1;18(17):6258-64. DMYQGDV RU https://pubmed.ncbi.nlm.nih.gov/20696581 DMSO8EU DI DMSO8EU DMSO8EU DN Mannotetraose DMSO8EU MI DE12T80 DMSO8EU MN Beta-mannosidase (manB) DMSO8EU MT DME DMSO8EU MA Metabolism DMSO8EU RN Structure and function of Bs164 beta-mannosidase from Bacteroides salyersiae the founding member of glycoside hydrolase family GH164. J Biol Chem. 2020 Mar 27;295(13):4316-4326. DMSO8EU RU https://pubmed.ncbi.nlm.nih.gov/31871050 DMB3GNC DI DMB3GNC DMB3GNC DN MANZAMINE A DMB3GNC MI TTL4Q97 DMB3GNC MN Cyclin-dependent kinase 5 (CDK5) DMB3GNC MT DTT DMB3GNC MA Inhibitor DMB3GNC RN Glycogen synthase kinase-3 (GSK-3) inhibitory activity and structure-activity relationship (SAR) studies of the manzamine alkaloids. Potential for ... J Nat Prod. 2007 Sep;70(9):1397-405. DMB3GNC RU https://pubmed.ncbi.nlm.nih.gov/17708655 DMB3GNC DI DMB3GNC DMB3GNC DN MANZAMINE A DMB3GNC MI TTRSMW9 DMB3GNC MN Glycogen synthase kinase-3 beta (GSK-3B) DMB3GNC MT DTT DMB3GNC MA Inhibitor DMB3GNC RN 2-N-Methyl modifications and SAR studies of manzamine A. Bioorg Med Chem. 2008 Jul 15;16(14):6702-6. DMB3GNC RU https://pubmed.ncbi.nlm.nih.gov/18595720 DMOI9RT DI DMOI9RT DMOI9RT DN Manzamine E DMOI9RT MI TTRSMW9 DMOI9RT MN Glycogen synthase kinase-3 beta (GSK-3B) DMOI9RT MT DTT DMOI9RT MA Inhibitor DMOI9RT RN Manzamine B and E and ircinal A related alkaloids from an Indonesian Acanthostrongylophora sponge and their activity against infectious, tropical p... J Nat Prod. 2006 Jul;69(7):1034-40. DMOI9RT RU https://pubmed.ncbi.nlm.nih.gov/16872140 DMC7ADZ DI DMC7ADZ DMC7ADZ DN Manzamine Y DMC7ADZ MI TTRSMW9 DMC7ADZ MN Glycogen synthase kinase-3 beta (GSK-3B) DMC7ADZ MT DTT DMC7ADZ MA Inhibitor DMC7ADZ RN Manzamine B and E and ircinal A related alkaloids from an Indonesian Acanthostrongylophora sponge and their activity against infectious, tropical p... J Nat Prod. 2006 Jul;69(7):1034-40. DMC7ADZ RU https://pubmed.ncbi.nlm.nih.gov/16872140 DMUCE93 DI DMUCE93 DMUCE93 DN MAP4 DMUCE93 MI TTICZ1O DMUCE93 MN Metabotropic glutamate receptor 4 (mGluR4) DMUCE93 MT DTT DMUCE93 MA Antagonist DMUCE93 RN Ligand binding to the amino-terminal domain of the mGluR4 subtype of metabotropic glutamate receptor. J Biol Chem. 1999 Apr 9;274(15):10008-13. DMUCE93 RU https://pubmed.ncbi.nlm.nih.gov/10187777 DMUCE93 DI DMUCE93 DMUCE93 DN MAP4 DMUCE93 MI TTWRP2F DMUCE93 MN Metabotropic glutamate receptor 6 (mGluR6) DMUCE93 MT DTT DMUCE93 MA Antagonist DMUCE93 RN The metabotropic glutamate receptors: structure, activation mechanism and pharmacology. Curr Drug Targets CNS Neurol Disord. 2002 Jun;1(3):297-317. DMUCE93 RU https://pubmed.ncbi.nlm.nih.gov/12769621 DMUCE93 DI DMUCE93 DMUCE93 DN MAP4 DMUCE93 MI TT0I76D DMUCE93 MN Metabotropic glutamate receptor 7 (mGluR7) DMUCE93 MT DTT DMUCE93 MA Antagonist DMUCE93 RN Binding of [3H](2S,1'S,2'S)-2-(9-xanthylmethyl)-2-(2'-carboxycyclopropyl) glycine ([3H]LY341495) to cell membranes expressing recombinant human group III metabotropic glutamate receptor subtypes. Naunyn Schmiedebergs Arch Pharmacol. 2000 Dec;362(6):546-54. DMUCE93 RU https://pubmed.ncbi.nlm.nih.gov/11138847 DMUCE93 DI DMUCE93 DMUCE93 DN MAP4 DMUCE93 MI TT0IFKL DMUCE93 MN Metabotropic glutamate receptor 8 (mGluR8) DMUCE93 MT DTT DMUCE93 MA Antagonist DMUCE93 RN Constraints on proper folding of the amino terminal domains of group III metabotropic glutamate receptors. Brain Res Mol Brain Res. 2000 Mar 10;76(1):180-90. DMUCE93 RU https://pubmed.ncbi.nlm.nih.gov/10719229 DMKT21X DI DMKT21X DMKT21X DN MAR-531 DMKT21X MI TT9O6WS DMKT21X MN Glucagon receptor (GCGR) DMKT21X MT DTT DMKT21X MA Modulator DMKT21X RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 251). DMKT21X RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=251 DMGF7XC DI DMGF7XC DMGF7XC DN MAR--99 DMGF7XC MI TTTWGIX DMGF7XC MN Leukotriene receptor (LTR) DMGF7XC MT DTT DMGF7XC MA Modulator DMGF7XC RN Effect of 1,6-dihydro-2[2-(2-methylpropoxy)anilino]-6-oxo-5-pyrimidineca rboxyli c acid on ethanol-induced microvascular injury in rats. Arzneimittelforschung. 1996 Aug;46(8):779-83. DMGF7XC RU https://pubmed.ncbi.nlm.nih.gov/9125278 DMN9UX3 DI DMN9UX3 DMN9UX3 DN MASLINIC ACID DMN9UX3 MI TTELIN2 DMN9UX3 MN PTPN1 messenger RNA (PTPN1 mRNA) DMN9UX3 MT DTT DMN9UX3 MA Inhibitor DMN9UX3 RN Synthesis and biological evaluation of heterocyclic ring-substituted maslinic acid derivatives as novel inhibitors of protein tyrosine phosphatase 1B. Bioorg Med Chem Lett. 2009 Dec 1;19(23):6618-22. DMN9UX3 RU https://pubmed.ncbi.nlm.nih.gov/19846303 DMDZIHT DI DMDZIHT DMDZIHT DN mast cell degranulating peptide DMDZIHT MI TTS3DIK DMDZIHT MN Voltage-gated potassium channel Kv1.1 (KCNA1) DMDZIHT MT DTT DMDZIHT MA Blocker (channel blocker) DMDZIHT RN Pharmacological characterization of five cloned voltage-gated K+ channels, types Kv1.1, 1.2, 1.3, 1.5, and 3.1, stably expressed in mammalian cell lines. Mol Pharmacol. 1994 Jun;45(6):1227-34. DMDZIHT RU https://pubmed.ncbi.nlm.nih.gov/7517498 DMDZIHT DI DMDZIHT DMDZIHT DN mast cell degranulating peptide DMDZIHT MI TTVFB0O DMDZIHT MN Voltage-gated potassium channel Kv1.2 (KCNA2) DMDZIHT MT DTT DMDZIHT MA Blocker (channel blocker) DMDZIHT RN Pharmacological characterization of five cloned voltage-gated K+ channels, types Kv1.1, 1.2, 1.3, 1.5, and 3.1, stably expressed in mammalian cell lines. Mol Pharmacol. 1994 Jun;45(6):1227-34. DMDZIHT RU https://pubmed.ncbi.nlm.nih.gov/7517498 DMDZIHT DI DMDZIHT DMDZIHT DN mast cell degranulating peptide DMDZIHT MI TTJ2W69 DMDZIHT MN Voltage-gated potassium channel Kv1.6 (KCNA6) DMDZIHT MT DTT DMDZIHT MA Blocker (channel blocker) DMDZIHT RN Cloning and expression of a human voltage-gated potassium channel. A novel member of the RCK potassium channel family. EMBO J. 1990 Jun;9(6):1749-56. DMDZIHT RU https://pubmed.ncbi.nlm.nih.gov/2347305 DM9KLQC DI DM9KLQC DM9KLQC DN MB-03966 DM9KLQC MI TTL732K DM9KLQC MN Adenosine kinase (ADK) DM9KLQC MT DTT DM9KLQC MA Inhibitor DM9KLQC RN Engineered Adenosine-Releasing Cells for Epilepsy Therapy: Human Mesenchymal Stem Cells and Human Embryonic Stem Cells. Neurotherapeutics. 2009 April; 6(2): 278-283. DM9KLQC RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2682344/ DMNRMKA DI DMNRMKA DMNRMKA DN MB-3 DMNRMKA MI TTVK7SB DMNRMKA MN Histone acetyltransferase KAT2B (KAT2B) DMNRMKA MT DTT DMNRMKA MA Inhibitor DMNRMKA RN Design, synthesis, and biological evaluation of a small-molecule inhibitor of the histone acetyltransferase Gcn5. Angew Chem Int Ed Engl. 2004 Jul 26;43(30):3974-6. DMNRMKA RU https://pubmed.ncbi.nlm.nih.gov/15274229 DM89WA1 DI DM89WA1 DM89WA1 DN MBX-3254 DM89WA1 MI TT7QNVC DM89WA1 MN Glucose-dependent insulinotropic receptor (GPR119) DM89WA1 MT DTT DM89WA1 MA Modulator DM89WA1 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 126). DM89WA1 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=126 DMPTNUQ DI DMPTNUQ DMPTNUQ DN MC-113 DMPTNUQ MI TT5TPI6 DMPTNUQ MN Opioid receptor sigma 1 (OPRS1) DMPTNUQ MT DTT DMPTNUQ MA Agonist DMPTNUQ RN Antitussives and substance abuse. Subst Abuse Rehabil. 2013 Nov 6;4:75-82. DMPTNUQ RU https://pubmed.ncbi.nlm.nih.gov/24648790 DMQC9UB DI DMQC9UB DMQC9UB DN MC-116 DMQC9UB MI TT5TPI6 DMQC9UB MN Opioid receptor sigma 1 (OPRS1) DMQC9UB MT DTT DMQC9UB MA Agonist DMQC9UB RN Antitussives and substance abuse. Subst Abuse Rehabil. 2013 Nov 6;4:75-82. DMQC9UB RU https://pubmed.ncbi.nlm.nih.gov/24648790 DM5RVO0 DI DM5RVO0 DM5RVO0 DN MC-1301 DM5RVO0 MI TTK59TV DM5RVO0 MN Vitamin D3 receptor (VDR) DM5RVO0 MT DTT DM5RVO0 MA Modulator DM5RVO0 RN Effects of 1,25-dihydroxyvitamin D3 and its 20-epi analogues (MC 1288, MC 1301, KH 1060), on clonal keratinocyte growth: evidence for differentiati... Br J Pharmacol. 1997 Mar;120(6):1119-27. DM5RVO0 RU https://www.ncbi.nlm.nih.gov/pubmed/9134225 DM6J2UZ DI DM6J2UZ DM6J2UZ DN MCC950 DM6J2UZ MI TT4EN8X DM6J2UZ MN Caterpiller protein 1.1 (NLRP3) DM6J2UZ MT DTT DM6J2UZ MA Inhibitor DM6J2UZ RN A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases. Nat Med. 2015 Mar;21(3):248-55. DM6J2UZ RU https://pubmed.ncbi.nlm.nih.gov/25686105 DMAHN4L DI DMAHN4L DMAHN4L DN MC-CAM DMAHN4L MI TT27RFC DMAHN4L MN Opioid receptor delta (OPRD1) DMAHN4L MT DTT DMAHN4L MA Inhibitor DMAHN4L RN 14beta-Arylpropiolylamino-17-cyclopropylmethyl-7,8-dihydronormorphinones and related opioids. Further examples of pseudoirreversible mu opioid rece... J Med Chem. 2009 Nov 12;52(21):6926-30. DMAHN4L RU https://pubmed.ncbi.nlm.nih.gov/19842669 DMAHN4L DI DMAHN4L DMAHN4L DN MC-CAM DMAHN4L MI TTQW87Y DMAHN4L MN Opioid receptor kappa (OPRK1) DMAHN4L MT DTT DMAHN4L MA Inhibitor DMAHN4L RN 14beta-Arylpropiolylamino-17-cyclopropylmethyl-7,8-dihydronormorphinones and related opioids. Further examples of pseudoirreversible mu opioid rece... J Med Chem. 2009 Nov 12;52(21):6926-30. DMAHN4L RU https://pubmed.ncbi.nlm.nih.gov/19842669 DMAHN4L DI DMAHN4L DMAHN4L DN MC-CAM DMAHN4L MI TTKWM86 DMAHN4L MN Opioid receptor mu (MOP) DMAHN4L MT DTT DMAHN4L MA Inhibitor DMAHN4L RN 14beta-Arylpropiolylamino-17-cyclopropylmethyl-7,8-dihydronormorphinones and related opioids. Further examples of pseudoirreversible mu opioid rece... J Med Chem. 2009 Nov 12;52(21):6926-30. DMAHN4L RU https://pubmed.ncbi.nlm.nih.gov/19842669 DMKTX1A DI DMKTX1A DMKTX1A DN MCCG DMKTX1A MI TT0I76D DMKTX1A MN Metabotropic glutamate receptor 7 (mGluR7) DMKTX1A MT DTT DMKTX1A MA Antagonist DMKTX1A RN Binding of [3H](2S,1'S,2'S)-2-(9-xanthylmethyl)-2-(2'-carboxycyclopropyl) glycine ([3H]LY341495) to cell membranes expressing recombinant human group III metabotropic glutamate receptor subtypes. Naunyn Schmiedebergs Arch Pharmacol. 2000 Dec;362(6):546-54. DMKTX1A RU https://pubmed.ncbi.nlm.nih.gov/11138847 DMM1J2D DI DMM1J2D DMM1J2D DN m-chlorophenylpiperazine DMM1J2D MI TT6MSOK DMM1J2D MN 5-HT 1D receptor (HTR1D) DMM1J2D MT DTT DMM1J2D MA Antagonist DMM1J2D RN Primary structure and functional characterization of a human 5-HT1D-type serotonin receptor. Mol Pharmacol. 1991 Aug;40(2):143-8. DMM1J2D RU https://pubmed.ncbi.nlm.nih.gov/1652050 DMM1J2D DI DMM1J2D DMM1J2D DN m-chlorophenylpiperazine DMM1J2D MI TTCPG9S DMM1J2D MN 5-HT 1E receptor (HTR1E) DMM1J2D MT DTT DMM1J2D MA Agonist DMM1J2D RN Molecular cloning and pharmacological characterization of the guinea pig 5-HT1E receptor. Eur J Pharmacol. 2004 Jan 26;484(2-3):127-39. DMM1J2D RU https://pubmed.ncbi.nlm.nih.gov/14744596 DMM1J2D DI DMM1J2D DMM1J2D DN m-chlorophenylpiperazine DMM1J2D MI TTJQOD7 DMM1J2D MN 5-HT 2A receptor (HTR2A) DMM1J2D MT DTT DMM1J2D MA Agonist DMM1J2D RN Comparisons of hallucinogenic phenylisopropylamine binding affinities at cloned human 5-HT2A, -HT(2B) and 5-HT2C receptors. Naunyn Schmiedebergs Arch Pharmacol. 1999 Jan;359(1):1-6. DMM1J2D RU https://pubmed.ncbi.nlm.nih.gov/9933142 DMM1J2D DI DMM1J2D DMM1J2D DN m-chlorophenylpiperazine DMM1J2D MI TT0K1SC DMM1J2D MN 5-HT 2B receptor (HTR2B) DMM1J2D MT DTT DMM1J2D MA Agonist DMM1J2D RN Pharmacological characteristics of the newly cloned rat 5-hydroxytryptamine2F receptor. Mol Pharmacol. 1993 Mar;43(3):419-26. DMM1J2D RU https://pubmed.ncbi.nlm.nih.gov/8450835 DMM1J2D DI DMM1J2D DMM1J2D DN m-chlorophenylpiperazine DMM1J2D MI TTWJBZ5 DMM1J2D MN 5-HT 2C receptor (HTR2C) DMM1J2D MT DTT DMM1J2D MA Agonist DMM1J2D RN Pharmacological profile of YM348, a novel, potent and orally active 5-HT2C receptor agonist. Eur J Pharmacol. 2004 Jan 1;483(1):37-43. DMM1J2D RU https://pubmed.ncbi.nlm.nih.gov/14709324 DMM1J2D DI DMM1J2D DMM1J2D DN m-chlorophenylpiperazine DMM1J2D MI TTJS8PY DMM1J2D MN 5-HT 6 receptor (HTR6) DMM1J2D MT DTT DMM1J2D MA Agonist DMM1J2D RN Cloning and expression of a novel serotonin receptor with high affinity for tricyclic psychotropic drugs. Mol Pharmacol. 1993 Mar;43(3):320-7. DMM1J2D RU https://pubmed.ncbi.nlm.nih.gov/7680751 DMM1J2D DI DMM1J2D DMM1J2D DN m-chlorophenylpiperazine DMM1J2D MI TTO9X1H DMM1J2D MN 5-HT 7 receptor (HTR7) DMM1J2D MT DTT DMM1J2D MA Agonist DMM1J2D RN Molecular cloning and expression of a 5-hydroxytryptamine7 serotonin receptor subtype. J Biol Chem. 1993 Aug 25;268(24):18200-4. DMM1J2D RU https://pubmed.ncbi.nlm.nih.gov/8394362 DMZ1YGI DI DMZ1YGI DMZ1YGI DN MCI DMZ1YGI MI TT85JO3 DMZ1YGI MN 5-HT receptor (5HTR) DMZ1YGI MT DTT DMZ1YGI MA Antagonist DMZ1YGI RN Effect of a serotonin receptor antagonist on interleukin-6-induced pulmonary hypertension in rats. Chest. 2001 Feb;119(2):554-61. DMZ1YGI RU https://pubmed.ncbi.nlm.nih.gov/11171737 DMFTPMX DI DMFTPMX DMFTPMX DN MCL0129 DMFTPMX MI TTD0CIQ DMFTPMX MN Melanocortin receptor 4 (MC4R) DMFTPMX MT DTT DMFTPMX MA Antagonist DMFTPMX RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 285). DMFTPMX RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=285 DMQIGZ7 DI DMQIGZ7 DMQIGZ7 DN MCL-117 DMQIGZ7 MI TT27RFC DMQIGZ7 MN Opioid receptor delta (OPRD1) DMQIGZ7 MT DTT DMQIGZ7 MA Inhibitor DMQIGZ7 RN Synthesis and preliminary in vitro investigation of bivalent ligands containing homo- and heterodimeric pharmacophores at mu, delta, and kappa opio... J Med Chem. 2006 Jan 12;49(1):256-62. DMQIGZ7 RU https://pubmed.ncbi.nlm.nih.gov/16392810 DMQIGZ7 DI DMQIGZ7 DMQIGZ7 DN MCL-117 DMQIGZ7 MI TTQW87Y DMQIGZ7 MN Opioid receptor kappa (OPRK1) DMQIGZ7 MT DTT DMQIGZ7 MA Inhibitor DMQIGZ7 RN Synthesis and preliminary in vitro investigation of bivalent ligands containing homo- and heterodimeric pharmacophores at mu, delta, and kappa opio... J Med Chem. 2006 Jan 12;49(1):256-62. DMQIGZ7 RU https://pubmed.ncbi.nlm.nih.gov/16392810 DMQIGZ7 DI DMQIGZ7 DMQIGZ7 DN MCL-117 DMQIGZ7 MI TTKWM86 DMQIGZ7 MN Opioid receptor mu (MOP) DMQIGZ7 MT DTT DMQIGZ7 MA Inhibitor DMQIGZ7 RN Synthesis and preliminary in vitro investigation of bivalent ligands containing homo- and heterodimeric pharmacophores at mu, delta, and kappa opio... J Med Chem. 2006 Jan 12;49(1):256-62. DMQIGZ7 RU https://pubmed.ncbi.nlm.nih.gov/16392810 DMQZC0U DI DMQZC0U DMQZC0U DN MCL-129 DMQZC0U MI TTD0CIQ DMQZC0U MN Melanocortin receptor 4 (MC4R) DMQZC0U MT DTT DMQZC0U MA Inhibitor DMQZC0U RN Structure-activity relationships of novel piperazines as antagonists for the melanocortin-4 receptor. Bioorg Med Chem. 2007 Mar 1;15(5):1989-2005. DMQZC0U RU https://pubmed.ncbi.nlm.nih.gov/17234422 DMQ1BDZ DI DMQ1BDZ DMQ1BDZ DN MCL-139 DMQ1BDZ MI TT27RFC DMQ1BDZ MN Opioid receptor delta (OPRD1) DMQ1BDZ MT DTT DMQ1BDZ MA Inhibitor DMQ1BDZ RN Synthesis and preliminary in vitro investigation of bivalent ligands containing homo- and heterodimeric pharmacophores at mu, delta, and kappa opio... J Med Chem. 2006 Jan 12;49(1):256-62. DMQ1BDZ RU https://pubmed.ncbi.nlm.nih.gov/16392810 DMQ1BDZ DI DMQ1BDZ DMQ1BDZ DN MCL-139 DMQ1BDZ MI TTQW87Y DMQ1BDZ MN Opioid receptor kappa (OPRK1) DMQ1BDZ MT DTT DMQ1BDZ MA Inhibitor DMQ1BDZ RN Synthesis and preliminary in vitro investigation of bivalent ligands containing homo- and heterodimeric pharmacophores at mu, delta, and kappa opio... J Med Chem. 2006 Jan 12;49(1):256-62. DMQ1BDZ RU https://pubmed.ncbi.nlm.nih.gov/16392810 DMQ1BDZ DI DMQ1BDZ DMQ1BDZ DN MCL-139 DMQ1BDZ MI TTKWM86 DMQ1BDZ MN Opioid receptor mu (MOP) DMQ1BDZ MT DTT DMQ1BDZ MA Inhibitor DMQ1BDZ RN Synthesis and preliminary in vitro investigation of bivalent ligands containing homo- and heterodimeric pharmacophores at mu, delta, and kappa opio... J Med Chem. 2006 Jan 12;49(1):256-62. DMQ1BDZ RU https://pubmed.ncbi.nlm.nih.gov/16392810 DMW7ZF8 DI DMW7ZF8 DMW7ZF8 DN MCL-144 DMW7ZF8 MI TT27RFC DMW7ZF8 MN Opioid receptor delta (OPRD1) DMW7ZF8 MT DTT DMW7ZF8 MA Inhibitor DMW7ZF8 RN Univalent and bivalent ligands of butorphan: characteristics of the linking chain determine the affinity and potency of such opioid ligands. J Med Chem. 2009 Dec 10;52(23):7389-96. DMW7ZF8 RU https://pubmed.ncbi.nlm.nih.gov/19634902 DMW7ZF8 DI DMW7ZF8 DMW7ZF8 DN MCL-144 DMW7ZF8 MI TTQW87Y DMW7ZF8 MN Opioid receptor kappa (OPRK1) DMW7ZF8 MT DTT DMW7ZF8 MA Inhibitor DMW7ZF8 RN Univalent and bivalent ligands of butorphan: characteristics of the linking chain determine the affinity and potency of such opioid ligands. J Med Chem. 2009 Dec 10;52(23):7389-96. DMW7ZF8 RU https://pubmed.ncbi.nlm.nih.gov/19634902 DMW7ZF8 DI DMW7ZF8 DMW7ZF8 DN MCL-144 DMW7ZF8 MI TTKWM86 DMW7ZF8 MN Opioid receptor mu (MOP) DMW7ZF8 MT DTT DMW7ZF8 MA Inhibitor DMW7ZF8 RN Univalent and bivalent ligands of butorphan: characteristics of the linking chain determine the affinity and potency of such opioid ligands. J Med Chem. 2009 Dec 10;52(23):7389-96. DMW7ZF8 RU https://pubmed.ncbi.nlm.nih.gov/19634902 DMJXU67 DI DMJXU67 DMJXU67 DN MCL-145 DMJXU67 MI TT27RFC DMJXU67 MN Opioid receptor delta (OPRD1) DMJXU67 MT DTT DMJXU67 MA Inhibitor DMJXU67 RN Synthesis and preliminary in vitro investigation of bivalent ligands containing homo- and heterodimeric pharmacophores at mu, delta, and kappa opio... J Med Chem. 2006 Jan 12;49(1):256-62. DMJXU67 RU https://pubmed.ncbi.nlm.nih.gov/16392810 DMJXU67 DI DMJXU67 DMJXU67 DN MCL-145 DMJXU67 MI TTQW87Y DMJXU67 MN Opioid receptor kappa (OPRK1) DMJXU67 MT DTT DMJXU67 MA Inhibitor DMJXU67 RN Synthesis and preliminary in vitro investigation of bivalent ligands containing homo- and heterodimeric pharmacophores at mu, delta, and kappa opio... J Med Chem. 2006 Jan 12;49(1):256-62. DMJXU67 RU https://pubmed.ncbi.nlm.nih.gov/16392810 DMJXU67 DI DMJXU67 DMJXU67 DN MCL-145 DMJXU67 MI TTKWM86 DMJXU67 MN Opioid receptor mu (MOP) DMJXU67 MT DTT DMJXU67 MA Inhibitor DMJXU67 RN Synthesis and preliminary in vitro investigation of bivalent ligands containing homo- and heterodimeric pharmacophores at mu, delta, and kappa opio... J Med Chem. 2006 Jan 12;49(1):256-62. DMJXU67 RU https://pubmed.ncbi.nlm.nih.gov/16392810 DMH5SMT DI DMH5SMT DMH5SMT DN MCL-147 DMH5SMT MI TT27RFC DMH5SMT MN Opioid receptor delta (OPRD1) DMH5SMT MT DTT DMH5SMT MA Inhibitor DMH5SMT RN In-vitro investigation of oxazol and urea analogues of morphinan at opioid receptors. Bioorg Med Chem. 2007 Jun 15;15(12):4106-12. DMH5SMT RU https://pubmed.ncbi.nlm.nih.gov/17433695 DMH5SMT DI DMH5SMT DMH5SMT DN MCL-147 DMH5SMT MI TTQW87Y DMH5SMT MN Opioid receptor kappa (OPRK1) DMH5SMT MT DTT DMH5SMT MA Inhibitor DMH5SMT RN In-vitro investigation of oxazol and urea analogues of morphinan at opioid receptors. Bioorg Med Chem. 2007 Jun 15;15(12):4106-12. DMH5SMT RU https://pubmed.ncbi.nlm.nih.gov/17433695 DMH5SMT DI DMH5SMT DMH5SMT DN MCL-147 DMH5SMT MI TTKWM86 DMH5SMT MN Opioid receptor mu (MOP) DMH5SMT MT DTT DMH5SMT MA Inhibitor DMH5SMT RN In-vitro investigation of oxazol and urea analogues of morphinan at opioid receptors. Bioorg Med Chem. 2007 Jun 15;15(12):4106-12. DMH5SMT RU https://pubmed.ncbi.nlm.nih.gov/17433695 DMTWY94 DI DMTWY94 DMTWY94 DN MCL-149 DMTWY94 MI TT27RFC DMTWY94 MN Opioid receptor delta (OPRD1) DMTWY94 MT DTT DMTWY94 MA Inhibitor DMTWY94 RN In-vitro investigation of oxazol and urea analogues of morphinan at opioid receptors. Bioorg Med Chem. 2007 Jun 15;15(12):4106-12. DMTWY94 RU https://pubmed.ncbi.nlm.nih.gov/17433695 DMTWY94 DI DMTWY94 DMTWY94 DN MCL-149 DMTWY94 MI TTQW87Y DMTWY94 MN Opioid receptor kappa (OPRK1) DMTWY94 MT DTT DMTWY94 MA Inhibitor DMTWY94 RN In-vitro investigation of oxazol and urea analogues of morphinan at opioid receptors. Bioorg Med Chem. 2007 Jun 15;15(12):4106-12. DMTWY94 RU https://pubmed.ncbi.nlm.nih.gov/17433695 DMTWY94 DI DMTWY94 DMTWY94 DN MCL-149 DMTWY94 MI TTKWM86 DMTWY94 MN Opioid receptor mu (MOP) DMTWY94 MT DTT DMTWY94 MA Inhibitor DMTWY94 RN In-vitro investigation of oxazol and urea analogues of morphinan at opioid receptors. Bioorg Med Chem. 2007 Jun 15;15(12):4106-12. DMTWY94 RU https://pubmed.ncbi.nlm.nih.gov/17433695 DMCPW5F DI DMCPW5F DMCPW5F DN MCL-153 DMCPW5F MI TT27RFC DMCPW5F MN Opioid receptor delta (OPRD1) DMCPW5F MT DTT DMCPW5F MA Inhibitor DMCPW5F RN Effect of linker substitution on the binding of butorphan univalent and bivalent ligands to opioid receptors. Bioorg Med Chem Lett. 2010 Mar 1;20(5):1507-9. DMCPW5F RU https://pubmed.ncbi.nlm.nih.gov/20144870 DMCPW5F DI DMCPW5F DMCPW5F DN MCL-153 DMCPW5F MI TTQW87Y DMCPW5F MN Opioid receptor kappa (OPRK1) DMCPW5F MT DTT DMCPW5F MA Inhibitor DMCPW5F RN Effect of linker substitution on the binding of butorphan univalent and bivalent ligands to opioid receptors. Bioorg Med Chem Lett. 2010 Mar 1;20(5):1507-9. DMCPW5F RU https://pubmed.ncbi.nlm.nih.gov/20144870 DMCPW5F DI DMCPW5F DMCPW5F DN MCL-153 DMCPW5F MI TTKWM86 DMCPW5F MN Opioid receptor mu (MOP) DMCPW5F MT DTT DMCPW5F MA Inhibitor DMCPW5F RN Effect of linker substitution on the binding of butorphan univalent and bivalent ligands to opioid receptors. Bioorg Med Chem Lett. 2010 Mar 1;20(5):1507-9. DMCPW5F RU https://pubmed.ncbi.nlm.nih.gov/20144870 DM3PIHV DI DM3PIHV DM3PIHV DN MCL-154 DM3PIHV MI TT27RFC DM3PIHV MN Opioid receptor delta (OPRD1) DM3PIHV MT DTT DM3PIHV MA Inhibitor DM3PIHV RN Effect of linker substitution on the binding of butorphan univalent and bivalent ligands to opioid receptors. Bioorg Med Chem Lett. 2010 Mar 1;20(5):1507-9. DM3PIHV RU https://pubmed.ncbi.nlm.nih.gov/20144870 DM3PIHV DI DM3PIHV DM3PIHV DN MCL-154 DM3PIHV MI TTQW87Y DM3PIHV MN Opioid receptor kappa (OPRK1) DM3PIHV MT DTT DM3PIHV MA Inhibitor DM3PIHV RN Effect of linker substitution on the binding of butorphan univalent and bivalent ligands to opioid receptors. Bioorg Med Chem Lett. 2010 Mar 1;20(5):1507-9. DM3PIHV RU https://pubmed.ncbi.nlm.nih.gov/20144870 DM3PIHV DI DM3PIHV DM3PIHV DN MCL-154 DM3PIHV MI TTKWM86 DM3PIHV MN Opioid receptor mu (MOP) DM3PIHV MT DTT DM3PIHV MA Inhibitor DM3PIHV RN Effect of linker substitution on the binding of butorphan univalent and bivalent ligands to opioid receptors. Bioorg Med Chem Lett. 2010 Mar 1;20(5):1507-9. DM3PIHV RU https://pubmed.ncbi.nlm.nih.gov/20144870 DM39YW1 DI DM39YW1 DM39YW1 DN MCL-182 DM39YW1 MI TT27RFC DM39YW1 MN Opioid receptor delta (OPRD1) DM39YW1 MT DTT DM39YW1 MA Inhibitor DM39YW1 RN In-vitro investigation of oxazol and urea analogues of morphinan at opioid receptors. Bioorg Med Chem. 2007 Jun 15;15(12):4106-12. DM39YW1 RU https://pubmed.ncbi.nlm.nih.gov/17433695 DM39YW1 DI DM39YW1 DM39YW1 DN MCL-182 DM39YW1 MI TTQW87Y DM39YW1 MN Opioid receptor kappa (OPRK1) DM39YW1 MT DTT DM39YW1 MA Inhibitor DM39YW1 RN In-vitro investigation of oxazol and urea analogues of morphinan at opioid receptors. Bioorg Med Chem. 2007 Jun 15;15(12):4106-12. DM39YW1 RU https://pubmed.ncbi.nlm.nih.gov/17433695 DM39YW1 DI DM39YW1 DM39YW1 DN MCL-182 DM39YW1 MI TTKWM86 DM39YW1 MN Opioid receptor mu (MOP) DM39YW1 MT DTT DM39YW1 MA Inhibitor DM39YW1 RN In-vitro investigation of oxazol and urea analogues of morphinan at opioid receptors. Bioorg Med Chem. 2007 Jun 15;15(12):4106-12. DM39YW1 RU https://pubmed.ncbi.nlm.nih.gov/17433695 DMVR51Z DI DMVR51Z DMVR51Z DN MCL-183 DMVR51Z MI TT27RFC DMVR51Z MN Opioid receptor delta (OPRD1) DMVR51Z MT DTT DMVR51Z MA Inhibitor DMVR51Z RN In-vitro investigation of oxazol and urea analogues of morphinan at opioid receptors. Bioorg Med Chem. 2007 Jun 15;15(12):4106-12. DMVR51Z RU https://pubmed.ncbi.nlm.nih.gov/17433695 DMVR51Z DI DMVR51Z DMVR51Z DN MCL-183 DMVR51Z MI TTQW87Y DMVR51Z MN Opioid receptor kappa (OPRK1) DMVR51Z MT DTT DMVR51Z MA Inhibitor DMVR51Z RN In-vitro investigation of oxazol and urea analogues of morphinan at opioid receptors. Bioorg Med Chem. 2007 Jun 15;15(12):4106-12. DMVR51Z RU https://pubmed.ncbi.nlm.nih.gov/17433695 DMVR51Z DI DMVR51Z DMVR51Z DN MCL-183 DMVR51Z MI TTKWM86 DMVR51Z MN Opioid receptor mu (MOP) DMVR51Z MT DTT DMVR51Z MA Inhibitor DMVR51Z RN In-vitro investigation of oxazol and urea analogues of morphinan at opioid receptors. Bioorg Med Chem. 2007 Jun 15;15(12):4106-12. DMVR51Z RU https://pubmed.ncbi.nlm.nih.gov/17433695 DM78F6A DI DM78F6A DM78F6A DN MCL-1-specific antisense oligonucleotide + midostaurin(PKC412) DM78F6A MI TTN6ORK DM78F6A MN Mcl-1 messenger RNA (MCL-1 mRNA) DM78F6A MT DTT DM78F6A RN Design and development of antisense drugs. Expert Opin. Drug Discov. 2008 3(10):1189-1207. DM78F6A RU http://www.informahealthcare.com/doi/abs/10.1517/17460441.3.10.1177 DM72GLY DI DM72GLY DM72GLY DN MCL-1-specific antisense oligonucleotide + nilotinib (AMN107) DM72GLY MI TTN6ORK DM72GLY MN Mcl-1 messenger RNA (MCL-1 mRNA) DM72GLY MT DTT DM72GLY RN Design and development of antisense drugs. Expert Opin. Drug Discov. 2008 3(10):1189-1207. DM72GLY RU http://www.informahealthcare.com/doi/abs/10.1517/17460441.3.10.1177 DMXBHE4 DI DMXBHE4 DMXBHE4 DN MCL-428 DMXBHE4 MI TT27RFC DMXBHE4 MN Opioid receptor delta (OPRD1) DMXBHE4 MT DTT DMXBHE4 MA Inhibitor DMXBHE4 RN High-affinity carbamate analogues of morphinan at opioid receptors. Bioorg Med Chem Lett. 2007 Mar 15;17(6):1508-11. DMXBHE4 RU https://pubmed.ncbi.nlm.nih.gov/17276685 DMXBHE4 DI DMXBHE4 DMXBHE4 DN MCL-428 DMXBHE4 MI TTQW87Y DMXBHE4 MN Opioid receptor kappa (OPRK1) DMXBHE4 MT DTT DMXBHE4 MA Inhibitor DMXBHE4 RN High-affinity carbamate analogues of morphinan at opioid receptors. Bioorg Med Chem Lett. 2007 Mar 15;17(6):1508-11. DMXBHE4 RU https://pubmed.ncbi.nlm.nih.gov/17276685 DMXBHE4 DI DMXBHE4 DMXBHE4 DN MCL-428 DMXBHE4 MI TTKWM86 DMXBHE4 MN Opioid receptor mu (MOP) DMXBHE4 MT DTT DMXBHE4 MA Inhibitor DMXBHE4 RN High-affinity carbamate analogues of morphinan at opioid receptors. Bioorg Med Chem Lett. 2007 Mar 15;17(6):1508-11. DMXBHE4 RU https://pubmed.ncbi.nlm.nih.gov/17276685 DM1XH04 DI DM1XH04 DM1XH04 DN MCL-429 DM1XH04 MI TT27RFC DM1XH04 MN Opioid receptor delta (OPRD1) DM1XH04 MT DTT DM1XH04 MA Inhibitor DM1XH04 RN High-affinity carbamate analogues of morphinan at opioid receptors. Bioorg Med Chem Lett. 2007 Mar 15;17(6):1508-11. DM1XH04 RU https://pubmed.ncbi.nlm.nih.gov/17276685 DM1XH04 DI DM1XH04 DM1XH04 DN MCL-429 DM1XH04 MI TTQW87Y DM1XH04 MN Opioid receptor kappa (OPRK1) DM1XH04 MT DTT DM1XH04 MA Inhibitor DM1XH04 RN High-affinity carbamate analogues of morphinan at opioid receptors. Bioorg Med Chem Lett. 2007 Mar 15;17(6):1508-11. DM1XH04 RU https://pubmed.ncbi.nlm.nih.gov/17276685 DM1XH04 DI DM1XH04 DM1XH04 DN MCL-429 DM1XH04 MI TTKWM86 DM1XH04 MN Opioid receptor mu (MOP) DM1XH04 MT DTT DM1XH04 MA Inhibitor DM1XH04 RN High-affinity carbamate analogues of morphinan at opioid receptors. Bioorg Med Chem Lett. 2007 Mar 15;17(6):1508-11. DM1XH04 RU https://pubmed.ncbi.nlm.nih.gov/17276685 DMISHCW DI DMISHCW DMISHCW DN MCL-431 DMISHCW MI TT27RFC DMISHCW MN Opioid receptor delta (OPRD1) DMISHCW MT DTT DMISHCW MA Inhibitor DMISHCW RN High-affinity carbamate analogues of morphinan at opioid receptors. Bioorg Med Chem Lett. 2007 Mar 15;17(6):1508-11. DMISHCW RU https://pubmed.ncbi.nlm.nih.gov/17276685 DMISHCW DI DMISHCW DMISHCW DN MCL-431 DMISHCW MI TTQW87Y DMISHCW MN Opioid receptor kappa (OPRK1) DMISHCW MT DTT DMISHCW MA Inhibitor DMISHCW RN High-affinity carbamate analogues of morphinan at opioid receptors. Bioorg Med Chem Lett. 2007 Mar 15;17(6):1508-11. DMISHCW RU https://pubmed.ncbi.nlm.nih.gov/17276685 DMISHCW DI DMISHCW DMISHCW DN MCL-431 DMISHCW MI TTKWM86 DMISHCW MN Opioid receptor mu (MOP) DMISHCW MT DTT DMISHCW MA Inhibitor DMISHCW RN High-affinity carbamate analogues of morphinan at opioid receptors. Bioorg Med Chem Lett. 2007 Mar 15;17(6):1508-11. DMISHCW RU https://pubmed.ncbi.nlm.nih.gov/17276685 DMPOFAR DI DMPOFAR DMPOFAR DN MCL-432 DMPOFAR MI TT27RFC DMPOFAR MN Opioid receptor delta (OPRD1) DMPOFAR MT DTT DMPOFAR MA Inhibitor DMPOFAR RN High-affinity carbamate analogues of morphinan at opioid receptors. Bioorg Med Chem Lett. 2007 Mar 15;17(6):1508-11. DMPOFAR RU https://pubmed.ncbi.nlm.nih.gov/17276685 DMPOFAR DI DMPOFAR DMPOFAR DN MCL-432 DMPOFAR MI TTQW87Y DMPOFAR MN Opioid receptor kappa (OPRK1) DMPOFAR MT DTT DMPOFAR MA Inhibitor DMPOFAR RN High-affinity carbamate analogues of morphinan at opioid receptors. Bioorg Med Chem Lett. 2007 Mar 15;17(6):1508-11. DMPOFAR RU https://pubmed.ncbi.nlm.nih.gov/17276685 DMPOFAR DI DMPOFAR DMPOFAR DN MCL-432 DMPOFAR MI TTKWM86 DMPOFAR MN Opioid receptor mu (MOP) DMPOFAR MT DTT DMPOFAR MA Inhibitor DMPOFAR RN High-affinity carbamate analogues of morphinan at opioid receptors. Bioorg Med Chem Lett. 2007 Mar 15;17(6):1508-11. DMPOFAR RU https://pubmed.ncbi.nlm.nih.gov/17276685 DMD3OAQ DI DMD3OAQ DMD3OAQ DN MCL-433 DMD3OAQ MI TT27RFC DMD3OAQ MN Opioid receptor delta (OPRD1) DMD3OAQ MT DTT DMD3OAQ MA Inhibitor DMD3OAQ RN High-affinity carbamate analogues of morphinan at opioid receptors. Bioorg Med Chem Lett. 2007 Mar 15;17(6):1508-11. DMD3OAQ RU https://pubmed.ncbi.nlm.nih.gov/17276685 DMD3OAQ DI DMD3OAQ DMD3OAQ DN MCL-433 DMD3OAQ MI TTQW87Y DMD3OAQ MN Opioid receptor kappa (OPRK1) DMD3OAQ MT DTT DMD3OAQ MA Inhibitor DMD3OAQ RN High-affinity carbamate analogues of morphinan at opioid receptors. Bioorg Med Chem Lett. 2007 Mar 15;17(6):1508-11. DMD3OAQ RU https://pubmed.ncbi.nlm.nih.gov/17276685 DMD3OAQ DI DMD3OAQ DMD3OAQ DN MCL-433 DMD3OAQ MI TTKWM86 DMD3OAQ MN Opioid receptor mu (MOP) DMD3OAQ MT DTT DMD3OAQ MA Inhibitor DMD3OAQ RN High-affinity carbamate analogues of morphinan at opioid receptors. Bioorg Med Chem Lett. 2007 Mar 15;17(6):1508-11. DMD3OAQ RU https://pubmed.ncbi.nlm.nih.gov/17276685 DMR31VO DI DMR31VO DMR31VO DN MCL-434 DMR31VO MI TT27RFC DMR31VO MN Opioid receptor delta (OPRD1) DMR31VO MT DTT DMR31VO MA Inhibitor DMR31VO RN High-affinity carbamate analogues of morphinan at opioid receptors. Bioorg Med Chem Lett. 2007 Mar 15;17(6):1508-11. DMR31VO RU https://pubmed.ncbi.nlm.nih.gov/17276685 DMR31VO DI DMR31VO DMR31VO DN MCL-434 DMR31VO MI TTQW87Y DMR31VO MN Opioid receptor kappa (OPRK1) DMR31VO MT DTT DMR31VO MA Inhibitor DMR31VO RN High-affinity carbamate analogues of morphinan at opioid receptors. Bioorg Med Chem Lett. 2007 Mar 15;17(6):1508-11. DMR31VO RU https://pubmed.ncbi.nlm.nih.gov/17276685 DMR31VO DI DMR31VO DMR31VO DN MCL-434 DMR31VO MI TTKWM86 DMR31VO MN Opioid receptor mu (MOP) DMR31VO MT DTT DMR31VO MA Inhibitor DMR31VO RN High-affinity carbamate analogues of morphinan at opioid receptors. Bioorg Med Chem Lett. 2007 Mar 15;17(6):1508-11. DMR31VO RU https://pubmed.ncbi.nlm.nih.gov/17276685 DMLSYD9 DI DMLSYD9 DMLSYD9 DN MCL-435 DMLSYD9 MI TT27RFC DMLSYD9 MN Opioid receptor delta (OPRD1) DMLSYD9 MT DTT DMLSYD9 MA Inhibitor DMLSYD9 RN High-affinity carbamate analogues of morphinan at opioid receptors. Bioorg Med Chem Lett. 2007 Mar 15;17(6):1508-11. DMLSYD9 RU https://pubmed.ncbi.nlm.nih.gov/17276685 DMLSYD9 DI DMLSYD9 DMLSYD9 DN MCL-435 DMLSYD9 MI TTQW87Y DMLSYD9 MN Opioid receptor kappa (OPRK1) DMLSYD9 MT DTT DMLSYD9 MA Inhibitor DMLSYD9 RN High-affinity carbamate analogues of morphinan at opioid receptors. Bioorg Med Chem Lett. 2007 Mar 15;17(6):1508-11. DMLSYD9 RU https://pubmed.ncbi.nlm.nih.gov/17276685 DMLSYD9 DI DMLSYD9 DMLSYD9 DN MCL-435 DMLSYD9 MI TTKWM86 DMLSYD9 MN Opioid receptor mu (MOP) DMLSYD9 MT DTT DMLSYD9 MA Inhibitor DMLSYD9 RN High-affinity carbamate analogues of morphinan at opioid receptors. Bioorg Med Chem Lett. 2007 Mar 15;17(6):1508-11. DMLSYD9 RU https://pubmed.ncbi.nlm.nih.gov/17276685 DM8LTQ4 DI DM8LTQ4 DM8LTQ4 DN MCL-443 DM8LTQ4 MI TT27RFC DM8LTQ4 MN Opioid receptor delta (OPRD1) DM8LTQ4 MT DTT DM8LTQ4 MA Inhibitor DM8LTQ4 RN High-affinity carbamate analogues of morphinan at opioid receptors. Bioorg Med Chem Lett. 2007 Mar 15;17(6):1508-11. DM8LTQ4 RU https://pubmed.ncbi.nlm.nih.gov/17276685 DM8LTQ4 DI DM8LTQ4 DM8LTQ4 DN MCL-443 DM8LTQ4 MI TTQW87Y DM8LTQ4 MN Opioid receptor kappa (OPRK1) DM8LTQ4 MT DTT DM8LTQ4 MA Inhibitor DM8LTQ4 RN High-affinity carbamate analogues of morphinan at opioid receptors. Bioorg Med Chem Lett. 2007 Mar 15;17(6):1508-11. DM8LTQ4 RU https://pubmed.ncbi.nlm.nih.gov/17276685 DM8LTQ4 DI DM8LTQ4 DM8LTQ4 DN MCL-443 DM8LTQ4 MI TTKWM86 DM8LTQ4 MN Opioid receptor mu (MOP) DM8LTQ4 MT DTT DM8LTQ4 MA Inhibitor DM8LTQ4 RN High-affinity carbamate analogues of morphinan at opioid receptors. Bioorg Med Chem Lett. 2007 Mar 15;17(6):1508-11. DM8LTQ4 RU https://pubmed.ncbi.nlm.nih.gov/17276685 DM8HALS DI DM8HALS DM8HALS DN MCL-444 DM8HALS MI TT27RFC DM8HALS MN Opioid receptor delta (OPRD1) DM8HALS MT DTT DM8HALS MA Inhibitor DM8HALS RN High-affinity carbamate analogues of morphinan at opioid receptors. Bioorg Med Chem Lett. 2007 Mar 15;17(6):1508-11. DM8HALS RU https://pubmed.ncbi.nlm.nih.gov/17276685 DM8HALS DI DM8HALS DM8HALS DN MCL-444 DM8HALS MI TTQW87Y DM8HALS MN Opioid receptor kappa (OPRK1) DM8HALS MT DTT DM8HALS MA Inhibitor DM8HALS RN High-affinity carbamate analogues of morphinan at opioid receptors. Bioorg Med Chem Lett. 2007 Mar 15;17(6):1508-11. DM8HALS RU https://pubmed.ncbi.nlm.nih.gov/17276685 DM8HALS DI DM8HALS DM8HALS DN MCL-444 DM8HALS MI TTKWM86 DM8HALS MN Opioid receptor mu (MOP) DM8HALS MT DTT DM8HALS MA Inhibitor DM8HALS RN High-affinity carbamate analogues of morphinan at opioid receptors. Bioorg Med Chem Lett. 2007 Mar 15;17(6):1508-11. DM8HALS RU https://pubmed.ncbi.nlm.nih.gov/17276685 DMR2K4F DI DMR2K4F DMR2K4F DN MCL-445 DMR2K4F MI TT27RFC DMR2K4F MN Opioid receptor delta (OPRD1) DMR2K4F MT DTT DMR2K4F MA Inhibitor DMR2K4F RN In-vitro investigation of oxazol and urea analogues of morphinan at opioid receptors. Bioorg Med Chem. 2007 Jun 15;15(12):4106-12. DMR2K4F RU https://pubmed.ncbi.nlm.nih.gov/17433695 DMR2K4F DI DMR2K4F DMR2K4F DN MCL-445 DMR2K4F MI TTQW87Y DMR2K4F MN Opioid receptor kappa (OPRK1) DMR2K4F MT DTT DMR2K4F MA Inhibitor DMR2K4F RN In-vitro investigation of oxazol and urea analogues of morphinan at opioid receptors. Bioorg Med Chem. 2007 Jun 15;15(12):4106-12. DMR2K4F RU https://pubmed.ncbi.nlm.nih.gov/17433695 DMR2K4F DI DMR2K4F DMR2K4F DN MCL-445 DMR2K4F MI TTKWM86 DMR2K4F MN Opioid receptor mu (MOP) DMR2K4F MT DTT DMR2K4F MA Inhibitor DMR2K4F RN In-vitro investigation of oxazol and urea analogues of morphinan at opioid receptors. Bioorg Med Chem. 2007 Jun 15;15(12):4106-12. DMR2K4F RU https://pubmed.ncbi.nlm.nih.gov/17433695 DMXF73G DI DMXF73G DMXF73G DN MCL-446 DMXF73G MI TT27RFC DMXF73G MN Opioid receptor delta (OPRD1) DMXF73G MT DTT DMXF73G MA Inhibitor DMXF73G RN In-vitro investigation of oxazol and urea analogues of morphinan at opioid receptors. Bioorg Med Chem. 2007 Jun 15;15(12):4106-12. DMXF73G RU https://pubmed.ncbi.nlm.nih.gov/17433695 DMXF73G DI DMXF73G DMXF73G DN MCL-446 DMXF73G MI TTQW87Y DMXF73G MN Opioid receptor kappa (OPRK1) DMXF73G MT DTT DMXF73G MA Inhibitor DMXF73G RN In-vitro investigation of oxazol and urea analogues of morphinan at opioid receptors. Bioorg Med Chem. 2007 Jun 15;15(12):4106-12. DMXF73G RU https://pubmed.ncbi.nlm.nih.gov/17433695 DMXF73G DI DMXF73G DMXF73G DN MCL-446 DMXF73G MI TTKWM86 DMXF73G MN Opioid receptor mu (MOP) DMXF73G MT DTT DMXF73G MA Inhibitor DMXF73G RN In-vitro investigation of oxazol and urea analogues of morphinan at opioid receptors. Bioorg Med Chem. 2007 Jun 15;15(12):4106-12. DMXF73G RU https://pubmed.ncbi.nlm.nih.gov/17433695 DMSTGNH DI DMSTGNH DMSTGNH DN MCL-447 DMSTGNH MI TT27RFC DMSTGNH MN Opioid receptor delta (OPRD1) DMSTGNH MT DTT DMSTGNH MA Inhibitor DMSTGNH RN In-vitro investigation of oxazol and urea analogues of morphinan at opioid receptors. Bioorg Med Chem. 2007 Jun 15;15(12):4106-12. DMSTGNH RU https://pubmed.ncbi.nlm.nih.gov/17433695 DMSTGNH DI DMSTGNH DMSTGNH DN MCL-447 DMSTGNH MI TTQW87Y DMSTGNH MN Opioid receptor kappa (OPRK1) DMSTGNH MT DTT DMSTGNH MA Inhibitor DMSTGNH RN In-vitro investigation of oxazol and urea analogues of morphinan at opioid receptors. Bioorg Med Chem. 2007 Jun 15;15(12):4106-12. DMSTGNH RU https://pubmed.ncbi.nlm.nih.gov/17433695 DMSTGNH DI DMSTGNH DMSTGNH DN MCL-447 DMSTGNH MI TTKWM86 DMSTGNH MN Opioid receptor mu (MOP) DMSTGNH MT DTT DMSTGNH MA Inhibitor DMSTGNH RN In-vitro investigation of oxazol and urea analogues of morphinan at opioid receptors. Bioorg Med Chem. 2007 Jun 15;15(12):4106-12. DMSTGNH RU https://pubmed.ncbi.nlm.nih.gov/17433695 DMSJGA9 DI DMSJGA9 DMSJGA9 DN MCL-448 DMSJGA9 MI TT27RFC DMSJGA9 MN Opioid receptor delta (OPRD1) DMSJGA9 MT DTT DMSJGA9 MA Inhibitor DMSJGA9 RN In-vitro investigation of oxazol and urea analogues of morphinan at opioid receptors. Bioorg Med Chem. 2007 Jun 15;15(12):4106-12. DMSJGA9 RU https://pubmed.ncbi.nlm.nih.gov/17433695 DMSJGA9 DI DMSJGA9 DMSJGA9 DN MCL-448 DMSJGA9 MI TTQW87Y DMSJGA9 MN Opioid receptor kappa (OPRK1) DMSJGA9 MT DTT DMSJGA9 MA Inhibitor DMSJGA9 RN In-vitro investigation of oxazol and urea analogues of morphinan at opioid receptors. Bioorg Med Chem. 2007 Jun 15;15(12):4106-12. DMSJGA9 RU https://pubmed.ncbi.nlm.nih.gov/17433695 DMSJGA9 DI DMSJGA9 DMSJGA9 DN MCL-448 DMSJGA9 MI TTKWM86 DMSJGA9 MN Opioid receptor mu (MOP) DMSJGA9 MT DTT DMSJGA9 MA Inhibitor DMSJGA9 RN In-vitro investigation of oxazol and urea analogues of morphinan at opioid receptors. Bioorg Med Chem. 2007 Jun 15;15(12):4106-12. DMSJGA9 RU https://pubmed.ncbi.nlm.nih.gov/17433695 DMQ890N DI DMQ890N DMQ890N DN MCL-449 DMQ890N MI TT27RFC DMQ890N MN Opioid receptor delta (OPRD1) DMQ890N MT DTT DMQ890N MA Inhibitor DMQ890N RN High-affinity carbamate analogues of morphinan at opioid receptors. Bioorg Med Chem Lett. 2007 Mar 15;17(6):1508-11. DMQ890N RU https://pubmed.ncbi.nlm.nih.gov/17276685 DMQ890N DI DMQ890N DMQ890N DN MCL-449 DMQ890N MI TTQW87Y DMQ890N MN Opioid receptor kappa (OPRK1) DMQ890N MT DTT DMQ890N MA Inhibitor DMQ890N RN High-affinity carbamate analogues of morphinan at opioid receptors. Bioorg Med Chem Lett. 2007 Mar 15;17(6):1508-11. DMQ890N RU https://pubmed.ncbi.nlm.nih.gov/17276685 DMQ890N DI DMQ890N DMQ890N DN MCL-449 DMQ890N MI TTKWM86 DMQ890N MN Opioid receptor mu (MOP) DMQ890N MT DTT DMQ890N MA Inhibitor DMQ890N RN High-affinity carbamate analogues of morphinan at opioid receptors. Bioorg Med Chem Lett. 2007 Mar 15;17(6):1508-11. DMQ890N RU https://pubmed.ncbi.nlm.nih.gov/17276685 DM7I6U8 DI DM7I6U8 DM7I6U8 DN MCL-450 DM7I6U8 MI TT27RFC DM7I6U8 MN Opioid receptor delta (OPRD1) DM7I6U8 MT DTT DM7I6U8 MA Inhibitor DM7I6U8 RN New opioid designed multiple ligand from Dmt-Tic and morphinan pharmacophores. J Med Chem. 2006 Sep 7;49(18):5640-3. DM7I6U8 RU https://pubmed.ncbi.nlm.nih.gov/16942040 DM7I6U8 DI DM7I6U8 DM7I6U8 DN MCL-450 DM7I6U8 MI TTQW87Y DM7I6U8 MN Opioid receptor kappa (OPRK1) DM7I6U8 MT DTT DM7I6U8 MA Inhibitor DM7I6U8 RN New opioid designed multiple ligand from Dmt-Tic and morphinan pharmacophores. J Med Chem. 2006 Sep 7;49(18):5640-3. DM7I6U8 RU https://pubmed.ncbi.nlm.nih.gov/16942040 DM7I6U8 DI DM7I6U8 DM7I6U8 DN MCL-450 DM7I6U8 MI TTKWM86 DM7I6U8 MN Opioid receptor mu (MOP) DM7I6U8 MT DTT DM7I6U8 MA Inhibitor DM7I6U8 RN New opioid designed multiple ligand from Dmt-Tic and morphinan pharmacophores. J Med Chem. 2006 Sep 7;49(18):5640-3. DM7I6U8 RU https://pubmed.ncbi.nlm.nih.gov/16942040 DMP523A DI DMP523A DMP523A DN MCL-451 DMP523A MI TT27RFC DMP523A MN Opioid receptor delta (OPRD1) DMP523A MT DTT DMP523A MA Inhibitor DMP523A RN New opioid designed multiple ligand from Dmt-Tic and morphinan pharmacophores. J Med Chem. 2006 Sep 7;49(18):5640-3. DMP523A RU https://pubmed.ncbi.nlm.nih.gov/16942040 DMP523A DI DMP523A DMP523A DN MCL-451 DMP523A MI TTQW87Y DMP523A MN Opioid receptor kappa (OPRK1) DMP523A MT DTT DMP523A MA Inhibitor DMP523A RN New opioid designed multiple ligand from Dmt-Tic and morphinan pharmacophores. J Med Chem. 2006 Sep 7;49(18):5640-3. DMP523A RU https://pubmed.ncbi.nlm.nih.gov/16942040 DMP523A DI DMP523A DMP523A DN MCL-451 DMP523A MI TTKWM86 DMP523A MN Opioid receptor mu (MOP) DMP523A MT DTT DMP523A MA Inhibitor DMP523A RN New opioid designed multiple ligand from Dmt-Tic and morphinan pharmacophores. J Med Chem. 2006 Sep 7;49(18):5640-3. DMP523A RU https://pubmed.ncbi.nlm.nih.gov/16942040 DMORMGU DI DMORMGU DMORMGU DN MCL-457 DMORMGU MI TTQW87Y DMORMGU MN Opioid receptor kappa (OPRK1) DMORMGU MT DTT DMORMGU MA Inhibitor DMORMGU RN In-vitro investigation of oxazol and urea analogues of morphinan at opioid receptors. Bioorg Med Chem. 2007 Jun 15;15(12):4106-12. DMORMGU RU https://pubmed.ncbi.nlm.nih.gov/17433695 DMORMGU DI DMORMGU DMORMGU DN MCL-457 DMORMGU MI TTKWM86 DMORMGU MN Opioid receptor mu (MOP) DMORMGU MT DTT DMORMGU MA Inhibitor DMORMGU RN In-vitro investigation of oxazol and urea analogues of morphinan at opioid receptors. Bioorg Med Chem. 2007 Jun 15;15(12):4106-12. DMORMGU RU https://pubmed.ncbi.nlm.nih.gov/17433695 DMZN93Y DI DMZN93Y DMZN93Y DN MCL-458 DMZN93Y MI TT27RFC DMZN93Y MN Opioid receptor delta (OPRD1) DMZN93Y MT DTT DMZN93Y MA Inhibitor DMZN93Y RN In-vitro investigation of oxazol and urea analogues of morphinan at opioid receptors. Bioorg Med Chem. 2007 Jun 15;15(12):4106-12. DMZN93Y RU https://pubmed.ncbi.nlm.nih.gov/17433695 DMZN93Y DI DMZN93Y DMZN93Y DN MCL-458 DMZN93Y MI TTQW87Y DMZN93Y MN Opioid receptor kappa (OPRK1) DMZN93Y MT DTT DMZN93Y MA Inhibitor DMZN93Y RN In-vitro investigation of oxazol and urea analogues of morphinan at opioid receptors. Bioorg Med Chem. 2007 Jun 15;15(12):4106-12. DMZN93Y RU https://pubmed.ncbi.nlm.nih.gov/17433695 DMZN93Y DI DMZN93Y DMZN93Y DN MCL-458 DMZN93Y MI TTKWM86 DMZN93Y MN Opioid receptor mu (MOP) DMZN93Y MT DTT DMZN93Y MA Inhibitor DMZN93Y RN In-vitro investigation of oxazol and urea analogues of morphinan at opioid receptors. Bioorg Med Chem. 2007 Jun 15;15(12):4106-12. DMZN93Y RU https://pubmed.ncbi.nlm.nih.gov/17433695 DMTB8D4 DI DMTB8D4 DMTB8D4 DN MCL-515 DMTB8D4 MI TTEX248 DMTB8D4 MN Dopamine D2 receptor (D2R) DMTB8D4 MT DTT DMTB8D4 MA Inhibitor DMTB8D4 RN Synthesis and neuropharmacological evaluation of esters of R(-)-N-alkyl-11-hydroxy-2-methoxynoraporphines. Bioorg Med Chem Lett. 2009 Jan 1;19(1):51-3. DMTB8D4 RU https://pubmed.ncbi.nlm.nih.gov/19058967 DMQA7ZI DI DMQA7ZI DMQA7ZI DN MCL-516 DMQA7ZI MI TTSQIFT DMQA7ZI MN 5-HT 1A receptor (HTR1A) DMQA7ZI MT DTT DMQA7ZI MA Inhibitor DMQA7ZI RN Synthesis and pharmacological investigation of novel 2-aminothiazole-privileged aporphines. Bioorg Med Chem. 2008 Jul 15;16(14):6675-81. DMQA7ZI RU https://pubmed.ncbi.nlm.nih.gov/18562201 DMQA7ZI DI DMQA7ZI DMQA7ZI DN MCL-516 DMQA7ZI MI TTZFYLI DMQA7ZI MN Dopamine D1 receptor (D1R) DMQA7ZI MT DTT DMQA7ZI MA Inhibitor DMQA7ZI RN Synthesis and neuropharmacological evaluation of esters of R(-)-N-alkyl-11-hydroxy-2-methoxynoraporphines. Bioorg Med Chem Lett. 2009 Jan 1;19(1):51-3. DMQA7ZI RU https://pubmed.ncbi.nlm.nih.gov/19058967 DMQA7ZI DI DMQA7ZI DMQA7ZI DN MCL-516 DMQA7ZI MI TTEX248 DMQA7ZI MN Dopamine D2 receptor (D2R) DMQA7ZI MT DTT DMQA7ZI MA Inhibitor DMQA7ZI RN Synthesis and neuropharmacological evaluation of esters of R(-)-N-alkyl-11-hydroxy-2-methoxynoraporphines. Bioorg Med Chem Lett. 2009 Jan 1;19(1):51-3. DMQA7ZI RU https://pubmed.ncbi.nlm.nih.gov/19058967 DML3AZG DI DML3AZG DML3AZG DN McN-A-343 DML3AZG MI TTOXS3C DML3AZG MN Muscarinic acetylcholine receptor (CHRM) DML3AZG MT DTT DML3AZG MA Agonist DML3AZG RN Pharmacological characterization of the M1 muscarinic receptors expressed in murine fibroblast B82 cells. J Pharmacol Exp Ther. 1989 Feb;248(2):661-70. DML3AZG RU https://pubmed.ncbi.nlm.nih.gov/2537406 DML3AZG DI DML3AZG DML3AZG DN McN-A-343 DML3AZG MI TTQ13Z5 DML3AZG MN Muscarinic acetylcholine receptor M3 (CHRM3) DML3AZG MT DTT DML3AZG MA Agonist DML3AZG RN Human muscarinic receptors expressed in A9L and CHO cells: activation by full and partial agonists. Br J Pharmacol. 1995 Mar;114(6):1241-9. DML3AZG RU https://pubmed.ncbi.nlm.nih.gov/7620715 DM0GLYB DI DM0GLYB DM0GLYB DN MCP-203 DM0GLYB MI TT27RFC DM0GLYB MN Opioid receptor delta (OPRD1) DM0GLYB MT DTT DM0GLYB MA Agonist DM0GLYB RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 317). DM0GLYB RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=317 DM0RZDF DI DM0RZDF DM0RZDF DN MCP-204 DM0RZDF MI TT27RFC DM0RZDF MN Opioid receptor delta (OPRD1) DM0RZDF MT DTT DM0RZDF MA Agonist DM0RZDF RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 317). DM0RZDF RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=317 DM3RYUZ DI DM3RYUZ DM3RYUZ DN MCP-205 DM3RYUZ MI TT27RFC DM3RYUZ MN Opioid receptor delta (OPRD1) DM3RYUZ MT DTT DM3RYUZ MA Agonist DM3RYUZ RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 317). DM3RYUZ RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=317 DMEUWB8 DI DMEUWB8 DMEUWB8 DN MDA-19 DMEUWB8 MI TTMSFAW DMEUWB8 MN Cannabinoid receptor 2 (CB2) DMEUWB8 MT DTT DMEUWB8 MA Agonist DMEUWB8 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 57). DMEUWB8 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=57 DMZJPOB DI DMZJPOB DMZJPOB DN MDDR 287569 DMZJPOB MI TT07C3Y DMZJPOB MN 5-HT 4 receptor (HTR4) DMZJPOB MT DTT DMZJPOB MA Modulator DMZJPOB RN Phase II study of Cilengitide (EMD 121974, NSC 707544) in patients with non-metastatic castration resistant prostate cancer, NCI-6735. A study by the DOD/PCF Prostate Cancer Clinical Trials Consortium. Invest New Drugs. 2012 April; 30(2): 749-757. DMZJPOB RU http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3175265/ DMLI5VH DI DMLI5VH DMLI5VH DN MDL 100,453 DMLI5VH MI TTKJEMQ DMLI5VH MN Glutamate receptor ionotropic NMDA 2A (NMDAR2A) DMLI5VH MT DTT DMLI5VH MA Antagonist DMLI5VH RN Differing effects of N-methyl-D-aspartate receptor subtype selective antagonists on dyskinesias in levodopa-treated 1-methyl-4-phenyl-tetrahydropyridine monkeys. J Pharmacol Exp Ther. 1999 Sep;290(3):1034-40. DMLI5VH RU https://pubmed.ncbi.nlm.nih.gov/10454475 DMTVOWC DI DMTVOWC DMTVOWC DN MDL-18962 DMTVOWC MI TTSZLWK DMTVOWC MN Aromatase (CYP19A1) DMTVOWC MT DTT DMTVOWC MA Inhibitor DMTVOWC RN 6 beta-Propynyl-substituted steroids: mechanism-based enzyme-activated irreversible inhibitors of aromatase. J Med Chem. 1997 Sep 26;40(20):3263-70. DMTVOWC RU https://pubmed.ncbi.nlm.nih.gov/9379446 DMUHJ2C DI DMUHJ2C DMUHJ2C DN MDL-28163 DMUHJ2C MI TTTIBOJ DMUHJ2C MN Histamine H1 receptor (H1R) DMUHJ2C MT DTT DMUHJ2C MA Inhibitor DMUHJ2C RN Designed multiple ligands. An emerging drug discovery paradigm. J Med Chem. 2005 Oct 20;48(21):6523-43. DMUHJ2C RU https://pubmed.ncbi.nlm.nih.gov/16220969 DMUHJ2C DI DMUHJ2C DMUHJ2C DN MDL-28163 DMUHJ2C MI TTZPO1L DMUHJ2C MN Substance-P receptor (TACR1) DMUHJ2C MT DTT DMUHJ2C MA Inhibitor DMUHJ2C RN Designed multiple ligands. An emerging drug discovery paradigm. J Med Chem. 2005 Oct 20;48(21):6523-43. DMUHJ2C RU https://pubmed.ncbi.nlm.nih.gov/16220969 DMF76M8 DI DMF76M8 DMF76M8 DN MDL-28618 DMF76M8 MI TTAWNKZ DMF76M8 MN Norepinephrine transporter (NET) DMF76M8 MT DTT DMF76M8 MA Inhibitor DMF76M8 RN Synthesis and structure-activity relationships of selective norepinephrine reuptake inhibitors (sNRI) with a heterocyclic ring constraint. Bioorg Med Chem Lett. 2008 Aug 15;18(16):4495-8. DMF76M8 RU https://pubmed.ncbi.nlm.nih.gov/18667309 DMF76M8 DI DMF76M8 DMF76M8 DN MDL-28618 DMF76M8 MI TT3ROYC DMF76M8 MN Serotonin transporter (SERT) DMF76M8 MT DTT DMF76M8 MA Inhibitor DMF76M8 RN Synthesis and structure-activity relationships of selective norepinephrine reuptake inhibitors (sNRI) with a heterocyclic ring constraint. Bioorg Med Chem Lett. 2008 Aug 15;18(16):4495-8. DMF76M8 RU https://pubmed.ncbi.nlm.nih.gov/18667309 DMF8VX3 DI DMF8VX3 DMF8VX3 DN MDL-74156 DMF8VX3 MI TTQ6VDM DMF8VX3 MN Voltage-gated potassium channel Kv11.1 (KCNH2) DMF8VX3 MT DTT DMF8VX3 MA Inhibitor DMF8VX3 RN Prediction of hERG potassium channel affinity by traditional and hologram qSAR methods. Bioorg Med Chem Lett. 2003 Aug 18;13(16):2773-5. DMF8VX3 RU https://pubmed.ncbi.nlm.nih.gov/12873512 DM8ZK12 DI DM8ZK12 DM8ZK12 DN MDP-01 DM8ZK12 MI TTGKNB4 DM8ZK12 MN Epidermal growth factor receptor (EGFR) DM8ZK12 MT DTT DM8ZK12 MA Inhibitor DM8ZK12 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1797). DM8ZK12 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1797 DMSF4UI DI DMSF4UI DMSF4UI DN MDT-006 DMSF4UI MI TTOZHQC DMSF4UI MN P2Y purinoceptor 2 (P2RY2) DMSF4UI MT DTT DMSF4UI MA Agonist DMSF4UI RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 324). DMSF4UI RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=324 DM9ZTX4 DI DM9ZTX4 DM9ZTX4 DN MDX-1147 DM9ZTX4 MI TT9G4N0 DM9ZTX4 MN Glutamate carboxypeptidase II (GCPII) DM9ZTX4 MT DTT DM9ZTX4 MA Modulator DM9ZTX4 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1606). DM9ZTX4 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1606 DMMFYP9 DI DMMFYP9 DMMFYP9 DN ME bromodomain inhibitor DMMFYP9 MI TTDP48B DMMFYP9 MN Bromodomain-containing protein 2 (BRD2) DMMFYP9 MT DTT DMMFYP9 MA Inhibitor DMMFYP9 RN Chemical biology. A bump-and-hole approach to engineer controlled selectivity of BET bromodomain chemical probes. Science. 2014 Oct 31;346(6209):638-41. DMMFYP9 RU https://pubmed.ncbi.nlm.nih.gov/25323695 DMCLT1V DI DMCLT1V DMCLT1V DN ME0328 DMCLT1V MI TTVDSZ0 DMCLT1V MN Poly [ADP-ribose] polymerase 1 (PARP1) DMCLT1V MT DTT DMCLT1V MA Inhibitor DMCLT1V RN Chemical probes to study ADP-ribosylation: synthesis and biochemical evaluation of inhibitors of the human ADP-ribosyltransferase ARTD3/PARP3. J Med Chem. 2013 Dec 12;56(23):9556-68. DMCLT1V RU https://pubmed.ncbi.nlm.nih.gov/24188023 DMCLT1V DI DMCLT1V DMCLT1V DN ME0328 DMCLT1V MI TTD8MEH DMCLT1V MN Poly [ADP-ribose] polymerase 3 (PARP3) DMCLT1V MT DTT DMCLT1V MA Inhibitor DMCLT1V RN Chemical probes to study ADP-ribosylation: synthesis and biochemical evaluation of inhibitors of the human ADP-ribosyltransferase ARTD3/PARP3. J Med Chem. 2013 Dec 12;56(23):9556-68. DMCLT1V RU https://pubmed.ncbi.nlm.nih.gov/24188023 DMOZAQ6 DI DMOZAQ6 DMOZAQ6 DN ME36 DMOZAQ6 MI TT953CX DMOZAQ6 MN Motilin receptor (MLNR) DMOZAQ6 MT DTT DMOZAQ6 MA Agonist DMOZAQ6 RN Desensitization of the human motilin receptor by motilides. J Pharmacol Exp Ther. 2005 Jun;313(3):1397-405. DMOZAQ6 RU https://pubmed.ncbi.nlm.nih.gov/15764739 DMO5E2L DI DMO5E2L DMO5E2L DN ME4 DMO5E2L MI TT953CX DMO5E2L MN Motilin receptor (MLNR) DMO5E2L MT DTT DMO5E2L MA Agonist DMO5E2L RN Desensitization of the human motilin receptor by motilides. J Pharmacol Exp Ther. 2005 Jun;313(3):1397-405. DMO5E2L RU https://pubmed.ncbi.nlm.nih.gov/15764739 DM3C6X2 DI DM3C6X2 DM3C6X2 DN ME67 DM3C6X2 MI TT953CX DM3C6X2 MN Motilin receptor (MLNR) DM3C6X2 MT DTT DM3C6X2 MA Agonist DM3C6X2 RN Desensitization of the human motilin receptor by motilides. J Pharmacol Exp Ther. 2005 Jun;313(3):1397-405. DM3C6X2 RU https://pubmed.ncbi.nlm.nih.gov/15764739 DM0P59E DI DM0P59E DM0P59E DN MEBUDIPINE DM0P59E MI TTZIFHC DM0P59E MN Voltage-gated calcium channel alpha Cav1.2 (CACNA1C) DM0P59E MT DTT DM0P59E MA Inhibitor DM0P59E RN Antagonism of 4-substituted 1,4-dihydropyridine-3,5-dicarboxylates toward voltage-dependent L-type Ca2+ channels Ca V 1.3 and Ca V 1.2. Bioorg Med Chem. 2010 May 1;18(9):3147-58. DM0P59E RU https://pubmed.ncbi.nlm.nih.gov/20382537 DM0P59E DI DM0P59E DM0P59E DN MEBUDIPINE DM0P59E MI TT7RGTM DM0P59E MN Voltage-gated calcium channel alpha Cav1.3 (CACNA1D) DM0P59E MT DTT DM0P59E MA Inhibitor DM0P59E RN Antagonism of 4-substituted 1,4-dihydropyridine-3,5-dicarboxylates toward voltage-dependent L-type Ca2+ channels Ca V 1.3 and Ca V 1.2. Bioorg Med Chem. 2010 May 1;18(9):3147-58. DM0P59E RU https://pubmed.ncbi.nlm.nih.gov/20382537 DMYQOKX DI DMYQOKX DMYQOKX DN MeBut-RYYRIK-NH2 DMYQOKX MI TTNT7K8 DMYQOKX MN Nociceptin receptor (OPRL1) DMYQOKX MT DTT DMYQOKX MA Inhibitor DMYQOKX RN Designed modification of partial agonist of ORL1 nociceptin receptor for conversion into highly potent antagonist. Bioorg Med Chem. 2008 Mar 1;16(5):2635-44. DMYQOKX RU https://pubmed.ncbi.nlm.nih.gov/18068993 DMNKSX3 DI DMNKSX3 DMNKSX3 DN Medazepam DMNKSX3 MI DE4LYSA DMNKSX3 MN Cytochrome P450 3A4 (CYP3A4) DMNKSX3 MT DME DMNKSX3 MA Metabolism DMNKSX3 RN Midazolam and other benzodiazepines. Handb Exp Pharmacol. 2008;(182):335-60. DMNKSX3 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=18175099 DMNKSX3 DI DMNKSX3 DMNKSX3 DN Medazepam DMNKSX3 MI DEGTFWK DMNKSX3 MN Mephenytoin 4-hydroxylase (CYP2C19) DMNKSX3 MT DME DMNKSX3 MA Metabolism DMNKSX3 RN Midazolam and other benzodiazepines. Handb Exp Pharmacol. 2008;(182):335-60. DMNKSX3 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=18175099 DMQ5S9C DI DMQ5S9C DMQ5S9C DN MEDI-552 DMQ5S9C MI TTUE541 DMQ5S9C MN Leukocyte surface antigen Leu-16 (CD20) DMQ5S9C MT DTT DMQ5S9C MA Modulator DMQ5S9C RN Anti CD37 antibodies DMQ5S9C RU https://www.google.com/patents/US9078879 DM960DQ DI DM960DQ DM960DQ DN MEDI-553 DM960DQ MI TTM6QSK DM960DQ MN B-cell receptor CD22 (CD22) DM960DQ MT DTT DM960DQ RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2786). DM960DQ RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2786 DML2GFB DI DML2GFB DML2GFB DN medica 16 DML2GFB MI TTB8FUC DML2GFB MN Free fatty acid receptor 1 (GPR40) DML2GFB MT DTT DML2GFB MA Agonist DML2GFB RN A human cell surface receptor activated by free fatty acids and thiazolidinedione drugs. Biochem Biophys Res Commun. 2003 Feb 7;301(2):406-10. DML2GFB RU https://pubmed.ncbi.nlm.nih.gov/12565875 DMDJ6RE DI DMDJ6RE DMDJ6RE DN MEDIORESINOL DMDJ6RE MI TTXV4FI DMDJ6RE MN Albendazole monooxygenase (CYP3A4) DMDJ6RE MT DTT DMDJ6RE MA Inhibitor DMDJ6RE RN Potent CYP3A4 inhibitory constituents of Piper cubeba. J Nat Prod. 2005 Jan;68(1):64-8. DMDJ6RE RU https://pubmed.ncbi.nlm.nih.gov/15679319 DMNEAJG DI DMNEAJG DMNEAJG DN Medrogestone DMNEAJG MI DE4LYSA DMNEAJG MN Cytochrome P450 3A4 (CYP3A4) DMNEAJG MT DME DMNEAJG MA Metabolism DMNEAJG RN Metabolism of medroxyprogesterone acetate (MPA) via CYP enzymes in vitro and effect of MPA on bleeding time in female rats in dependence on CYP activity in vivo. Life Sci. 2003 Nov 7;73(25):3201-12. DMNEAJG RU https://www.ncbi.nlm.nih.gov/pubmed/?term=14561525 DMYJI90 DI DMYJI90 DMYJI90 DN MEK inhibitor I DMYJI90 MI TTROQ37 DMYJI90 MN MAPK/ERK kinase kinase (MAP3K) DMYJI90 MT DTT DMYJI90 MA Inhibitor DMYJI90 RN Beyond U0126. Dianion chemistry leading to the rapid synthesis of a series of potent MEK inhibitors. Bioorg Med Chem Lett. 2004 Mar 22;14(6):1483-6. DMYJI90 RU https://pubmed.ncbi.nlm.nih.gov/15006386 DM08SVH DI DM08SVH DM08SVH DN MEL57A DM08SVH MI TTNB6UQ DM08SVH MN Hyperpolarization cyclic nucleotide-gated channel 1 (HCN1) DM08SVH MT DTT DM08SVH MA Blocker (channel blocker) DM08SVH RN Novel blockers of hyperpolarization-activated current with isoform selectivity in recombinant cells and native tissue. Br J Pharmacol. 2012 May;166(2):602-16. DM08SVH RU https://pubmed.ncbi.nlm.nih.gov/22091830 DMY57L0 DI DMY57L0 DMY57L0 DN melanin-concentrating hormone DMY57L0 MI TTX4RTB DMY57L0 MN Melanin-concentrating hormone receptor 1 (MCHR1) DMY57L0 MT DTT DMY57L0 MA Agonist DMY57L0 RN [125I]-S36057: a new and highly potent radioligand for the melanin-concentrating hormone receptor. Br J Pharmacol. 2001 Jun;133(3):371-8. DMY57L0 RU https://pubmed.ncbi.nlm.nih.gov/11375253 DMY57L0 DI DMY57L0 DMY57L0 DN melanin-concentrating hormone DMY57L0 MI TTS17MG DMY57L0 MN Melanin-concentrating hormone receptor 2 (MCHR2) DMY57L0 MT DTT DMY57L0 MA Agonist DMY57L0 RN Identification and characterization of a second melanin-concentrating hormone receptor, MCH-2R. Proc Natl Acad Sci U S A. 2001 Jun 19;98(13):7564-9. DMY57L0 RU https://pubmed.ncbi.nlm.nih.gov/11404457 DM2ES7Z DI DM2ES7Z DM2ES7Z DN Melanocortin-4 Receptor antagonist DM2ES7Z MI TTD0CIQ DM2ES7Z MN Melanocortin receptor 4 (MC4R) DM2ES7Z MT DTT DM2ES7Z MA Antagonist DM2ES7Z RN Emerging drugs for eating disorder treatment. Expert Opin Emerg Drugs. 2006 May;11(2):315-36. DM2ES7Z RU https://pubmed.ncbi.nlm.nih.gov/16634704 DMTKLH8 DI DMTKLH8 DMTKLH8 DN Melibiose DMTKLH8 MI DEUOBTJ DMTKLH8 MN Alpha-galactosidase (melA) DMTKLH8 MT DME DMTKLH8 MA Metabolism DMTKLH8 RN Use of an alpha-galactosidase gene as a food-grade selection marker for Streptococcus thermophilus. J Dairy Sci. 2005 Jul;88(7):2341-7. DMTKLH8 RU https://pubmed.ncbi.nlm.nih.gov/15956297 DMTKLH8 DI DMTKLH8 DMTKLH8 DN Melibiose DMTKLH8 MI DEKI69B DMTKLH8 MN Alpha-galactosidase (melA) DMTKLH8 MT DME DMTKLH8 MA Metabolism DMTKLH8 RN Alpha-glactosidase activity of lactobacilli. Appl Microbiol. 1973 Nov;26(5):783-8. DMTKLH8 RU https://pubmed.ncbi.nlm.nih.gov/4796954 DMTKLH8 DI DMTKLH8 DMTKLH8 DN Melibiose DMTKLH8 MI DEBK21A DMTKLH8 MN Alpha-galactosidase (melA) DMTKLH8 MT DME DMTKLH8 MA Metabolism DMTKLH8 RN Alpha-glactosidase activity of lactobacilli. Appl Microbiol. 1973 Nov;26(5):783-8. DMTKLH8 RU https://pubmed.ncbi.nlm.nih.gov/4796954 DMTKLH8 DI DMTKLH8 DMTKLH8 DN Melibiose DMTKLH8 MI DEY2UXF DMTKLH8 MN Alpha-galactosidase (melA) DMTKLH8 MT DME DMTKLH8 MA Metabolism DMTKLH8 RN Alpha-glactosidase activity of lactobacilli. Appl Microbiol. 1973 Nov;26(5):783-8. DMTKLH8 RU https://pubmed.ncbi.nlm.nih.gov/4796954 DMTKLH8 DI DMTKLH8 DMTKLH8 DN Melibiose DMTKLH8 MI DE3N1MH DMTKLH8 MN Alpha-galactosidase (melA) DMTKLH8 MT DME DMTKLH8 MA Metabolism DMTKLH8 RN Alpha-glactosidase activity of lactobacilli. Appl Microbiol. 1973 Nov;26(5):783-8. DMTKLH8 RU https://pubmed.ncbi.nlm.nih.gov/4796954 DMTKLH8 DI DMTKLH8 DMTKLH8 DN Melibiose DMTKLH8 MI DE5EODL DMTKLH8 MN Beta-fructofuranosidase (BFRU) DMTKLH8 MT DME DMTKLH8 MA Metabolism DMTKLH8 RN Alpha-glactosidase activity of lactobacilli. Appl Microbiol. 1973 Nov;26(5):783-8. DMTKLH8 RU https://pubmed.ncbi.nlm.nih.gov/4796954 DMTKLH8 DI DMTKLH8 DMTKLH8 DN Melibiose DMTKLH8 MI DER8TO2 DMTKLH8 MN Beta-fructofuranosidase (BFRU) DMTKLH8 MT DME DMTKLH8 MA Metabolism DMTKLH8 RN Alpha-glactosidase activity of lactobacilli. Appl Microbiol. 1973 Nov;26(5):783-8. DMTKLH8 RU https://pubmed.ncbi.nlm.nih.gov/4796954 DMTKLH8 DI DMTKLH8 DMTKLH8 DN Melibiose DMTKLH8 MI DEET5ZQ DMTKLH8 MN Beta-fructofuranosidase (BFRU) DMTKLH8 MT DME DMTKLH8 MA Metabolism DMTKLH8 RN Alpha-glactosidase activity of lactobacilli. Appl Microbiol. 1973 Nov;26(5):783-8. DMTKLH8 RU https://pubmed.ncbi.nlm.nih.gov/4796954 DME54M7 DI DME54M7 DME54M7 DN Melogatran DME54M7 MI TT6L509 DME54M7 MN Coagulation factor IIa (F2) DME54M7 MT DTT DME54M7 MA Inhibitor DME54M7 RN Thrombin inhibitors in acute coronary artery disease. Eur Heart J. 2002 Aug;23(15):1142-4. DME54M7 RU https://pubmed.ncbi.nlm.nih.gov/12127916 DM3492O DI DM3492O DM3492O DN MELOSMINE DM3492O MI TTZFYLI DM3492O MN Dopamine D1 receptor (D1R) DM3492O MT DTT DM3492O MA Inhibitor DM3492O RN Advances in development of dopaminergic aporphinoids. J Med Chem. 2007 Jan 25;50(2):171-81. DM3492O RU https://pubmed.ncbi.nlm.nih.gov/17228858 DM9S30P DI DM9S30P DM9S30P DN MEMOQUIN DM9S30P MI TT1RS9F DM9S30P MN Acetylcholinesterase (AChE) DM9S30P MT DTT DM9S30P MA Inhibitor DM9S30P RN Toward a rational design of multitarget-directed antioxidants: merging memoquin and lipoic acid molecular frameworks. J Med Chem. 2009 Dec 10;52(23):7883-6. DM9S30P RU https://pubmed.ncbi.nlm.nih.gov/19813747 DM9S30P DI DM9S30P DM9S30P DN MEMOQUIN DM9S30P MI TTEB0GD DM9S30P MN Cholinesterase (BCHE) DM9S30P MT DTT DM9S30P MA Inhibitor DM9S30P RN Toward a rational design of multitarget-directed antioxidants: merging memoquin and lipoic acid molecular frameworks. J Med Chem. 2009 Dec 10;52(23):7883-6. DM9S30P RU https://pubmed.ncbi.nlm.nih.gov/19813747 DMEIRDX DI DMEIRDX DMEIRDX DN MEN-14295 DMEIRDX MI TTGTQHC DMEIRDX MN DNA topoisomerase I (TOP1) DMEIRDX MT DTT DMEIRDX MA Inhibitor DMEIRDX RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2636). DMEIRDX RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2636 DMU8L7C DI DMU8L7C DMU8L7C DN Mepacrine DMU8L7C MI DTI7UX6 DMU8L7C MN Breast cancer resistance protein (ABCG2) DMU8L7C MT DTP DMU8L7C MA Substrate DMU8L7C RN Arginine-482 is not essential for transport of antibiotics, primary bile acids and unconjugated sterols by the human breast cancer resistance protein (ABCG2). Biochem J. 2005 Jan 15;385(Pt 2):419-26. DMU8L7C RU https://doi.org/10.1042/BJ20040791 DMU8L7C DI DMU8L7C DMU8L7C DN Mepacrine DMU8L7C MI DE4LYSA DMU8L7C MN Cytochrome P450 3A4 (CYP3A4) DMU8L7C MT DME DMU8L7C MA Metabolism DMU8L7C RN Quinacrine is mainly metabolized to mono-desethyl quinacrine by CYP3A4/5 and its brain accumulation is limited by P-glycoprotein. Drug Metab Dispos. 2006 Jul;34(7):1136-44. DMU8L7C RU https://www.ncbi.nlm.nih.gov/pubmed/?term=16581945 DMU8L7C DI DMU8L7C DMU8L7C DN Mepacrine DMU8L7C MI DEIBDNY DMU8L7C MN Cytochrome P450 3A5 (CYP3A5) DMU8L7C MT DME DMU8L7C MA Metabolism DMU8L7C RN Quinacrine is mainly metabolized to mono-desethyl quinacrine by CYP3A4/5 and its brain accumulation is limited by P-glycoprotein. Drug Metab Dispos. 2006 Jul;34(7):1136-44. DMU8L7C RU https://www.ncbi.nlm.nih.gov/pubmed/?term=16581945 DMU8L7C DI DMU8L7C DMU8L7C DN Mepacrine DMU8L7C MI TT9V5JH DMU8L7C MN Phospholipase A2 (PLA2G1B) DMU8L7C MT DTT DMU8L7C MA Inhibitor DMU8L7C RN Involvement of protein kinase C activation in L-leucine-induced stimulation of protein synthesis in l6 myotubes. Cytotechnology. 2003 Nov;43(1-3):97-103. DMU8L7C RU https://pubmed.ncbi.nlm.nih.gov/19003213 DMZIA1R DI DMZIA1R DMZIA1R DN mercaptoacrylate inhibitor of calpain 1 DMZIA1R MI TTG5QB7 DMZIA1R MN Calpain-2 (CAPN2) DMZIA1R MT DTT DMZIA1R MA Inhibitor DMZIA1R RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2336). DMZIA1R RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2336 DM68FZK DI DM68FZK DM68FZK DN Mercaptosuccinate DM68FZK MI DEVNY51 DM68FZK MN Mercaptosuccinate dioxygenase (efe) DM68FZK MT DME DM68FZK MA Metabolism DM68FZK RN Mercaptosuccinate dioxygenase, a cysteine dioxygenase homologue, from Variovorax paradoxus strain B4 is the key enzyme of mercaptosuccinate degradation. J Biol Chem. 2014 Oct 31;289(44):30800-9. DM68FZK RU https://pubmed.ncbi.nlm.nih.gov/25228698 DMD25I6 DI DMD25I6 DMD25I6 DN MERCK-544 DMD25I6 MI TTN7BL9 DMD25I6 MN Corticosteroid 11-beta-dehydrogenase 1 (HSD11B1) DMD25I6 MT DTT DMD25I6 MA Inhibitor DMD25I6 RN Azabicyclic sulfonamides as potent 11beta-HSD1 inhibitors. Bioorg Med Chem Lett. 2010 Mar 1;20(5):1551-4. DMD25I6 RU https://pubmed.ncbi.nlm.nih.gov/20149650 DMT56ER DI DMT56ER DMT56ER DN Mercuribenzoic Acid DMT56ER MI TTANPDJ DMT56ER MN Carbonic anhydrase II (CA-II) DMT56ER MT DTT DMT56ER MA Inhibitor DMT56ER RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMT56ER RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMPZ0XJ DI DMPZ0XJ DMPZ0XJ DN Merimepodib DMPZ0XJ MI TTTU6X1 DMPZ0XJ MN HUMAN inosine-5'-monophosphate dehydrogenase 2 (IMPDH2) DMPZ0XJ MT DTT DMPZ0XJ MA Inhibitor DMPZ0XJ RN The IMPDH inhibitor merimepodib suppresses SARS-CoV-2 replication in vitro. April 09, 2020. doi: https://doi.org/10.1101/2020.04.07.028589 DMPZ0XJ RU https://www.biorxiv.org/content/10.1101/2020.04.07.028589v1 DMJT93H DI DMJT93H DMJT93H DN MERIOLIN 1 DMJT93H MI TTAMQ62 DMJT93H MN Cyclin A2 (CCNA2) DMJT93H MT DTT DMJT93H MA Inhibitor DMJT93H RN Meriolins (3-(pyrimidin-4-yl)-7-azaindoles): synthesis, kinase inhibitory activity, cellular effects, and structure of a CDK2/cyclin A/meriolin com... J Med Chem. 2008 Feb 28;51(4):737-51. DMJT93H RU https://pubmed.ncbi.nlm.nih.gov/18232649 DMJT93H DI DMJT93H DMJT93H DN MERIOLIN 1 DMJT93H MI TT7HF4W DMJT93H MN Cyclin-dependent kinase 2 (CDK2) DMJT93H MT DTT DMJT93H MA Inhibitor DMJT93H RN Meriolins (3-(pyrimidin-4-yl)-7-azaindoles): synthesis, kinase inhibitory activity, cellular effects, and structure of a CDK2/cyclin A/meriolin com... J Med Chem. 2008 Feb 28;51(4):737-51. DMJT93H RU https://pubmed.ncbi.nlm.nih.gov/18232649 DMJT93H DI DMJT93H DMJT93H DN MERIOLIN 1 DMJT93H MI TT1LVF2 DMJT93H MN Cyclin-dependent kinase 9 (CDK9) DMJT93H MT DTT DMJT93H MA Inhibitor DMJT93H RN Meriolins (3-(pyrimidin-4-yl)-7-azaindoles): synthesis, kinase inhibitory activity, cellular effects, and structure of a CDK2/cyclin A/meriolin com... J Med Chem. 2008 Feb 28;51(4):737-51. DMJT93H RU https://pubmed.ncbi.nlm.nih.gov/18232649 DM413XJ DI DM413XJ DM413XJ DN MERIOLIN 2 DM413XJ MI TTAMQ62 DM413XJ MN Cyclin A2 (CCNA2) DM413XJ MT DTT DM413XJ MA Inhibitor DM413XJ RN Meriolins (3-(pyrimidin-4-yl)-7-azaindoles): synthesis, kinase inhibitory activity, cellular effects, and structure of a CDK2/cyclin A/meriolin com... J Med Chem. 2008 Feb 28;51(4):737-51. DM413XJ RU https://pubmed.ncbi.nlm.nih.gov/18232649 DM413XJ DI DM413XJ DM413XJ DN MERIOLIN 2 DM413XJ MI TT7HF4W DM413XJ MN Cyclin-dependent kinase 2 (CDK2) DM413XJ MT DTT DM413XJ MA Inhibitor DM413XJ RN Meriolins (3-(pyrimidin-4-yl)-7-azaindoles): synthesis, kinase inhibitory activity, cellular effects, and structure of a CDK2/cyclin A/meriolin com... J Med Chem. 2008 Feb 28;51(4):737-51. DM413XJ RU https://pubmed.ncbi.nlm.nih.gov/18232649 DM413XJ DI DM413XJ DM413XJ DN MERIOLIN 2 DM413XJ MI TT1LVF2 DM413XJ MN Cyclin-dependent kinase 9 (CDK9) DM413XJ MT DTT DM413XJ MA Inhibitor DM413XJ RN Meriolins (3-(pyrimidin-4-yl)-7-azaindoles): synthesis, kinase inhibitory activity, cellular effects, and structure of a CDK2/cyclin A/meriolin com... J Med Chem. 2008 Feb 28;51(4):737-51. DM413XJ RU https://pubmed.ncbi.nlm.nih.gov/18232649 DMVE95S DI DMVE95S DMVE95S DN MERIOLIN 3 DMVE95S MI TTAMQ62 DMVE95S MN Cyclin A2 (CCNA2) DMVE95S MT DTT DMVE95S MA Inhibitor DMVE95S RN Meriolins (3-(pyrimidin-4-yl)-7-azaindoles): synthesis, kinase inhibitory activity, cellular effects, and structure of a CDK2/cyclin A/meriolin com... J Med Chem. 2008 Feb 28;51(4):737-51. DMVE95S RU https://pubmed.ncbi.nlm.nih.gov/18232649 DMVE95S DI DMVE95S DMVE95S DN MERIOLIN 3 DMVE95S MI TT7HF4W DMVE95S MN Cyclin-dependent kinase 2 (CDK2) DMVE95S MT DTT DMVE95S MA Inhibitor DMVE95S RN Meriolins (3-(pyrimidin-4-yl)-7-azaindoles): synthesis, kinase inhibitory activity, cellular effects, and structure of a CDK2/cyclin A/meriolin com... J Med Chem. 2008 Feb 28;51(4):737-51. DMVE95S RU https://pubmed.ncbi.nlm.nih.gov/18232649 DMVE95S DI DMVE95S DMVE95S DN MERIOLIN 3 DMVE95S MI TT1LVF2 DMVE95S MN Cyclin-dependent kinase 9 (CDK9) DMVE95S MT DTT DMVE95S MA Inhibitor DMVE95S RN Meriolins (3-(pyrimidin-4-yl)-7-azaindoles): synthesis, kinase inhibitory activity, cellular effects, and structure of a CDK2/cyclin A/meriolin com... J Med Chem. 2008 Feb 28;51(4):737-51. DMVE95S RU https://pubmed.ncbi.nlm.nih.gov/18232649 DMIJMZQ DI DMIJMZQ DMIJMZQ DN MERIOLIN 4 DMIJMZQ MI TTAMQ62 DMIJMZQ MN Cyclin A2 (CCNA2) DMIJMZQ MT DTT DMIJMZQ MA Inhibitor DMIJMZQ RN Meriolins (3-(pyrimidin-4-yl)-7-azaindoles): synthesis, kinase inhibitory activity, cellular effects, and structure of a CDK2/cyclin A/meriolin com... J Med Chem. 2008 Feb 28;51(4):737-51. DMIJMZQ RU https://pubmed.ncbi.nlm.nih.gov/18232649 DMIJMZQ DI DMIJMZQ DMIJMZQ DN MERIOLIN 4 DMIJMZQ MI TT7HF4W DMIJMZQ MN Cyclin-dependent kinase 2 (CDK2) DMIJMZQ MT DTT DMIJMZQ MA Inhibitor DMIJMZQ RN Meriolins (3-(pyrimidin-4-yl)-7-azaindoles): synthesis, kinase inhibitory activity, cellular effects, and structure of a CDK2/cyclin A/meriolin com... J Med Chem. 2008 Feb 28;51(4):737-51. DMIJMZQ RU https://pubmed.ncbi.nlm.nih.gov/18232649 DMIJMZQ DI DMIJMZQ DMIJMZQ DN MERIOLIN 4 DMIJMZQ MI TT1LVF2 DMIJMZQ MN Cyclin-dependent kinase 9 (CDK9) DMIJMZQ MT DTT DMIJMZQ MA Inhibitor DMIJMZQ RN Meriolins (3-(pyrimidin-4-yl)-7-azaindoles): synthesis, kinase inhibitory activity, cellular effects, and structure of a CDK2/cyclin A/meriolin com... J Med Chem. 2008 Feb 28;51(4):737-51. DMIJMZQ RU https://pubmed.ncbi.nlm.nih.gov/18232649 DMGVLR0 DI DMGVLR0 DMGVLR0 DN MERIOLIN 5 DMGVLR0 MI TTAMQ62 DMGVLR0 MN Cyclin A2 (CCNA2) DMGVLR0 MT DTT DMGVLR0 MA Inhibitor DMGVLR0 RN Meriolins (3-(pyrimidin-4-yl)-7-azaindoles): synthesis, kinase inhibitory activity, cellular effects, and structure of a CDK2/cyclin A/meriolin com... J Med Chem. 2008 Feb 28;51(4):737-51. DMGVLR0 RU https://pubmed.ncbi.nlm.nih.gov/18232649 DMGVLR0 DI DMGVLR0 DMGVLR0 DN MERIOLIN 5 DMGVLR0 MI TT7HF4W DMGVLR0 MN Cyclin-dependent kinase 2 (CDK2) DMGVLR0 MT DTT DMGVLR0 MA Inhibitor DMGVLR0 RN Meriolins (3-(pyrimidin-4-yl)-7-azaindoles): synthesis, kinase inhibitory activity, cellular effects, and structure of a CDK2/cyclin A/meriolin com... J Med Chem. 2008 Feb 28;51(4):737-51. DMGVLR0 RU https://pubmed.ncbi.nlm.nih.gov/18232649 DMGVLR0 DI DMGVLR0 DMGVLR0 DN MERIOLIN 5 DMGVLR0 MI TT1LVF2 DMGVLR0 MN Cyclin-dependent kinase 9 (CDK9) DMGVLR0 MT DTT DMGVLR0 MA Inhibitor DMGVLR0 RN Meriolins (3-(pyrimidin-4-yl)-7-azaindoles): synthesis, kinase inhibitory activity, cellular effects, and structure of a CDK2/cyclin A/meriolin com... J Med Chem. 2008 Feb 28;51(4):737-51. DMGVLR0 RU https://pubmed.ncbi.nlm.nih.gov/18232649 DMW5AXC DI DMW5AXC DMW5AXC DN MERIOLIN 6 DMW5AXC MI TTAMQ62 DMW5AXC MN Cyclin A2 (CCNA2) DMW5AXC MT DTT DMW5AXC MA Inhibitor DMW5AXC RN Meriolins (3-(pyrimidin-4-yl)-7-azaindoles): synthesis, kinase inhibitory activity, cellular effects, and structure of a CDK2/cyclin A/meriolin com... J Med Chem. 2008 Feb 28;51(4):737-51. DMW5AXC RU https://pubmed.ncbi.nlm.nih.gov/18232649 DMW5AXC DI DMW5AXC DMW5AXC DN MERIOLIN 6 DMW5AXC MI TT7HF4W DMW5AXC MN Cyclin-dependent kinase 2 (CDK2) DMW5AXC MT DTT DMW5AXC MA Inhibitor DMW5AXC RN Meriolins (3-(pyrimidin-4-yl)-7-azaindoles): synthesis, kinase inhibitory activity, cellular effects, and structure of a CDK2/cyclin A/meriolin com... J Med Chem. 2008 Feb 28;51(4):737-51. DMW5AXC RU https://pubmed.ncbi.nlm.nih.gov/18232649 DMW5AXC DI DMW5AXC DMW5AXC DN MERIOLIN 6 DMW5AXC MI TT1LVF2 DMW5AXC MN Cyclin-dependent kinase 9 (CDK9) DMW5AXC MT DTT DMW5AXC MA Inhibitor DMW5AXC RN Meriolins (3-(pyrimidin-4-yl)-7-azaindoles): synthesis, kinase inhibitory activity, cellular effects, and structure of a CDK2/cyclin A/meriolin com... J Med Chem. 2008 Feb 28;51(4):737-51. DMW5AXC RU https://pubmed.ncbi.nlm.nih.gov/18232649 DM8D3NY DI DM8D3NY DM8D3NY DN MERIOLIN 7 DM8D3NY MI TTAMQ62 DM8D3NY MN Cyclin A2 (CCNA2) DM8D3NY MT DTT DM8D3NY MA Inhibitor DM8D3NY RN Meriolins (3-(pyrimidin-4-yl)-7-azaindoles): synthesis, kinase inhibitory activity, cellular effects, and structure of a CDK2/cyclin A/meriolin com... J Med Chem. 2008 Feb 28;51(4):737-51. DM8D3NY RU https://pubmed.ncbi.nlm.nih.gov/18232649 DM8D3NY DI DM8D3NY DM8D3NY DN MERIOLIN 7 DM8D3NY MI TT1LVF2 DM8D3NY MN Cyclin-dependent kinase 9 (CDK9) DM8D3NY MT DTT DM8D3NY MA Inhibitor DM8D3NY RN Meriolins (3-(pyrimidin-4-yl)-7-azaindoles): synthesis, kinase inhibitory activity, cellular effects, and structure of a CDK2/cyclin A/meriolin com... J Med Chem. 2008 Feb 28;51(4):737-51. DM8D3NY RU https://pubmed.ncbi.nlm.nih.gov/18232649 DM0E95B DI DM0E95B DM0E95B DN MERIOLIN 8 DM0E95B MI TTAMQ62 DM0E95B MN Cyclin A2 (CCNA2) DM0E95B MT DTT DM0E95B MA Inhibitor DM0E95B RN Meriolins (3-(pyrimidin-4-yl)-7-azaindoles): synthesis, kinase inhibitory activity, cellular effects, and structure of a CDK2/cyclin A/meriolin com... J Med Chem. 2008 Feb 28;51(4):737-51. DM0E95B RU https://pubmed.ncbi.nlm.nih.gov/18232649 DM0E95B DI DM0E95B DM0E95B DN MERIOLIN 8 DM0E95B MI TT7HF4W DM0E95B MN Cyclin-dependent kinase 2 (CDK2) DM0E95B MT DTT DM0E95B MA Inhibitor DM0E95B RN Meriolins (3-(pyrimidin-4-yl)-7-azaindoles): synthesis, kinase inhibitory activity, cellular effects, and structure of a CDK2/cyclin A/meriolin com... J Med Chem. 2008 Feb 28;51(4):737-51. DM0E95B RU https://pubmed.ncbi.nlm.nih.gov/18232649 DM0E95B DI DM0E95B DM0E95B DN MERIOLIN 8 DM0E95B MI TT1LVF2 DM0E95B MN Cyclin-dependent kinase 9 (CDK9) DM0E95B MT DTT DM0E95B MA Inhibitor DM0E95B RN Meriolins (3-(pyrimidin-4-yl)-7-azaindoles): synthesis, kinase inhibitory activity, cellular effects, and structure of a CDK2/cyclin A/meriolin com... J Med Chem. 2008 Feb 28;51(4):737-51. DM0E95B RU https://pubmed.ncbi.nlm.nih.gov/18232649 DMYVUCE DI DMYVUCE DMYVUCE DN MESCALINE DMYVUCE MI TTJQOD7 DMYVUCE MN 5-HT 2A receptor (HTR2A) DMYVUCE MT DTT DMYVUCE MA Inhibitor DMYVUCE RN The role of lipophilicity in determining binding affinity and functional activity for 5-HT2A receptor ligands. Bioorg Med Chem. 2008 Apr 15;16(8):4661-9. DMYVUCE RU https://pubmed.ncbi.nlm.nih.gov/18296055 DM86WRO DI DM86WRO DM86WRO DN meso-DAP DM86WRO MI TTYSRXM DM86WRO MN Pattern recognition receptor NOD1 (NOD1) DM86WRO MT DTT DM86WRO MA Agonist DM86WRO RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1762). DM86WRO RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1762 DMZ12GE DI DMZ12GE DMZ12GE DN MESUAGENIN A DMZ12GE MI TT1RS9F DMZ12GE MN Acetylcholinesterase (AChE) DMZ12GE MT DTT DMZ12GE MA Inhibitor DMZ12GE RN 4-Phenylcoumarins from Mesua elegans with acetylcholinesterase inhibitory activity. Bioorg Med Chem. 2010 Nov 15;18(22):7873-7. DMZ12GE RU https://pubmed.ncbi.nlm.nih.gov/20943395 DMKXG3V DI DMKXG3V DMKXG3V DN MESUAGENIN B DMKXG3V MI TT1RS9F DMKXG3V MN Acetylcholinesterase (AChE) DMKXG3V MT DTT DMKXG3V MA Inhibitor DMKXG3V RN 4-Phenylcoumarins from Mesua elegans with acetylcholinesterase inhibitory activity. Bioorg Med Chem. 2010 Nov 15;18(22):7873-7. DMKXG3V RU https://pubmed.ncbi.nlm.nih.gov/20943395 DMLZGO7 DI DMLZGO7 DMLZGO7 DN Mesuagenin D DMLZGO7 MI TT1RS9F DMLZGO7 MN Acetylcholinesterase (AChE) DMLZGO7 MT DTT DMLZGO7 MA Inhibitor DMLZGO7 RN 4-Phenylcoumarins from Mesua elegans with acetylcholinesterase inhibitory activity. Bioorg Med Chem. 2010 Nov 15;18(22):7873-7. DMLZGO7 RU https://pubmed.ncbi.nlm.nih.gov/20943395 DMKGWAH DI DMKGWAH DMKGWAH DN MESULERGINE DMKGWAH MI TTPC4TU DMKGWAH MN 5-HT 3A receptor (HTR3A) DMKGWAH MT DTT DMKGWAH MA Inhibitor DMKGWAH RN Novel and highly potent 5-HT3 receptor agonists based on a pyrroloquinoxaline structure. J Med Chem. 1997 Oct 24;40(22):3670-8. DMKGWAH RU https://pubmed.ncbi.nlm.nih.gov/9357534 DMKGWAH DI DMKGWAH DMKGWAH DN MESULERGINE DMKGWAH MI TTR6K75 DMKGWAH MN 5-HT 3B receptor (HTR3B) DMKGWAH MT DTT DMKGWAH MA Inhibitor DMKGWAH RN Novel and highly potent 5-HT3 receptor agonists based on a pyrroloquinoxaline structure. J Med Chem. 1997 Oct 24;40(22):3670-8. DMKGWAH RU https://pubmed.ncbi.nlm.nih.gov/9357534 DMKGWAH DI DMKGWAH DMKGWAH DN MESULERGINE DMKGWAH MI TTO9X1H DMKGWAH MN 5-HT 7 receptor (HTR7) DMKGWAH MT DTT DMKGWAH MA Inhibitor DMKGWAH RN Synthesis of new serotonin 5-HT7 receptor ligands. Determinants of 5-HT7/5-HT1A receptor selectivity. J Med Chem. 2009 Apr 23;52(8):2384-92. DMKGWAH RU https://pubmed.ncbi.nlm.nih.gov/19326916 DMKGWAH DI DMKGWAH DMKGWAH DN MESULERGINE DMKGWAH MI TTJFY5U DMKGWAH MN Adenosine A3 receptor (ADORA3) DMKGWAH MT DTT DMKGWAH MA Inhibitor DMKGWAH RN 2-n-Butyl-9-methyl-8-[1,2,3]triazol-2-yl-9H-purin-6-ylamine and analogues as A2A adenosine receptor antagonists. Design, synthesis, and pharmacolog... J Med Chem. 2005 Nov 3;48(22):6887-96. DMKGWAH RU https://pubmed.ncbi.nlm.nih.gov/16250647 DMEA8GP DI DMEA8GP DMEA8GP DN meta-chlorphenylbiguanide DMEA8GP MI TTPC4TU DMEA8GP MN 5-HT 3A receptor (HTR3A) DMEA8GP MT DTT DMEA8GP MA Agonist DMEA8GP RN Different efficacy of specific agonists at 5-HT3 receptor splice variants: the role of the extra six amino acid segment. Br J Pharmacol. 1998 Feb;123(4):661-6. DMEA8GP RU https://pubmed.ncbi.nlm.nih.gov/9517385 DMEA8GP DI DMEA8GP DMEA8GP DN meta-chlorphenylbiguanide DMEA8GP MI TTR6K75 DMEA8GP MN 5-HT 3B receptor (HTR3B) DMEA8GP MT DTT DMEA8GP MA Agonist DMEA8GP RN Pharmacological comparison of human homomeric 5-HT3A receptors versus heteromeric 5-HT3A/3B receptors. Neuropharmacology. 2001 Aug;41(2):282-4. DMEA8GP RU https://pubmed.ncbi.nlm.nih.gov/11489465 DMTGMB1 DI DMTGMB1 DMTGMB1 DN Metanephrine DMTGMB1 MI TTJ6ESR DMTGMB1 MN Catecholamine uptake (CA uptake) DMTGMB1 MT DTT DMTGMB1 MA Inhibitor DMTGMB1 RN Catecholamine uptake blockade in anaesthetized dogs: influence on cardiovascular responses. J Pharm Pharmacol. 1979 Nov;31(11):761-6. DMTGMB1 RU https://pubmed.ncbi.nlm.nih.gov/41908 DMITMN9 DI DMITMN9 DMITMN9 DN Meta-Nitro-Tyrosine DMITMN9 MI TTEP6RV DMITMN9 MN Glutathione reductase (GR) DMITMN9 MT DTT DMITMN9 MA Inhibitor DMITMN9 RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMITMN9 RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMSK0QX DI DMSK0QX DMSK0QX DN Meta-sirtinol DMSK0QX MI TTUF2HO DMSK0QX MN NAD-dependent deacetylase sirtuin-1 (SIRT1) DMSK0QX MT DTT DMSK0QX MA Inhibitor DMSK0QX RN Design, synthesis, and biological evaluation of sirtinol analogues as class III histone/protein deacetylase (Sirtuin) inhibitors. J Med Chem. 2005 Dec 1;48(24):7789-95. DMSK0QX RU https://pubmed.ncbi.nlm.nih.gov/16302818 DM0748C DI DM0748C DM0748C DN Meta-Tyrosine DM0748C MI TTUHP71 DM0748C MN Tyrosine 3-monooxygenase (TH) DM0748C MT DTT DM0748C MA Inhibitor DM0748C RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DM0748C RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMQBGH9 DI DMQBGH9 DMQBGH9 DN Metazamide DMQBGH9 MI TTKN8W0 DMQBGH9 MN Glucose-6-phosphate dehydrogenase (G6PD) DMQBGH9 MT DTT DMQBGH9 MA Inhibitor DMQBGH9 RN Glucose utilization and activity of glucose-6-phosphate dehydrogenase, isocitrate dehydrogenase and malate dehydrogenase in rat erythrocytes after treatment with tuberculostatic agents. Vopr Med Khim. 1986 Sep-Oct;32(5):32-5. DMQBGH9 RU https://pubmed.ncbi.nlm.nih.gov/3776114 DMB6T23 DI DMB6T23 DMB6T23 DN METAZOCINE DMB6T23 MI TT27RFC DMB6T23 MN Opioid receptor delta (OPRD1) DMB6T23 MT DTT DMB6T23 MA Inhibitor DMB6T23 RN Syntheses and opioid receptor binding properties of carboxamido-substituted opioids. Bioorg Med Chem Lett. 2009 Jan 1;19(1):203-8. DMB6T23 RU https://pubmed.ncbi.nlm.nih.gov/19027293 DMB6T23 DI DMB6T23 DMB6T23 DN METAZOCINE DMB6T23 MI TTQW87Y DMB6T23 MN Opioid receptor kappa (OPRK1) DMB6T23 MT DTT DMB6T23 MA Inhibitor DMB6T23 RN Syntheses and opioid receptor binding properties of carboxamido-substituted opioids. Bioorg Med Chem Lett. 2009 Jan 1;19(1):203-8. DMB6T23 RU https://pubmed.ncbi.nlm.nih.gov/19027293 DMB6T23 DI DMB6T23 DMB6T23 DN METAZOCINE DMB6T23 MI TTKWM86 DMB6T23 MN Opioid receptor mu (MOP) DMB6T23 MT DTT DMB6T23 MA Inhibitor DMB6T23 RN Synthesis and biological evaluation of a metazocine-containing enkephalinamide. Evidence for nonidentical roles of the tyramine moiety in opiates a... J Med Chem. 1982 Dec;25(12):1423-7. DMB6T23 RU https://pubmed.ncbi.nlm.nih.gov/7154002 DMDASC6 DI DMDASC6 DMDASC6 DN Metformin DMDASC6 MI TTKV8W5 DMDASC6 MN HUMAN mannose receptor (MRC1) DMDASC6 MT DTT DMDASC6 MA Inhibitor DMDASC6 RN A SARS-CoV-2-Human Protein-Protein Interaction Map Reveals Drug Targets and Potential Drug-Repurposing. March 2020 DMDASC6 RU https://www.researchgate.net/publication/340097421_A_SARS-CoV-2-Human_Protein-Protein_Interaction_Map_Reveals_Drug_Targets_and_Potential_Drug-Repurposing DMZVF6M DI DMZVF6M DMZVF6M DN Methanandamide DMZVF6M MI TT6OEDT DMZVF6M MN Cannabinoid receptor 1 (CB1) DMZVF6M MT DTT DMZVF6M MA Antagonist DMZVF6M RN Methanandamide attenuates cocaine-induced hyperthermia in rats by a cannabinoid CB1-dopamine D2 receptor mechanism. Brain Res. 2009 Mar 13;1260:7-14. DMZVF6M RU https://pubmed.ncbi.nlm.nih.gov/19401177 DMVQSEH DI DMVQSEH DMVQSEH DN Methimepip DMVQSEH MI TT9JNIC DMVQSEH MN Histamine H3 receptor (H3R) DMVQSEH MT DTT DMVQSEH MA Agonist DMVQSEH RN The histamine H3 receptor: from gene cloning to H3 receptor drugs. Nat Rev Drug Discov. 2005 Feb;4(2):107-20. DMVQSEH RU https://pubmed.ncbi.nlm.nih.gov/15665857 DMEIP6H DI DMEIP6H DMEIP6H DN methionine benzimidazole 6 DMEIP6H MI TT5Y4EM DMEIP6H MN N-formyl peptide receptor (FPR1) DMEIP6H MT DTT DMEIP6H MA Antagonist DMEIP6H RN Discovery of small molecule human FPR1 receptor antagonists. Bioorg Med Chem Lett. 2011 May 15;21(10):2991-7. DMEIP6H RU https://pubmed.ncbi.nlm.nih.gov/21486695 DMOUTNA DI DMOUTNA DMOUTNA DN Methionine Phosphonate DMOUTNA MI TTOJ46K DMOUTNA MN Streptococcus Methionyl-tRNA synthetase (Stre-coc metG) DMOUTNA MT DTT DMOUTNA MA Inhibitor DMOUTNA RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMOUTNA RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMKE18W DI DMKE18W DMKE18W DN Methionine Sulfoxide DMKE18W MI TTE4KHA DMKE18W MN Amyloid beta A4 protein (APP) DMKE18W MT DTT DMKE18W MA Inhibitor DMKE18W RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DMKE18W RU https://pubmed.ncbi.nlm.nih.gov/10592235 DMKE18W DI DMKE18W DMKE18W DN Methionine Sulfoxide DMKE18W MI TTU6BFZ DMKE18W MN Candida Thymidylate synthase (Candi TMP1) DMKE18W MT DTT DMKE18W MA Inhibitor DMKE18W RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DMKE18W RU https://pubmed.ncbi.nlm.nih.gov/10592235 DMMC0I7 DI DMMC0I7 DMMC0I7 DN METHIOTHEPIN DMMC0I7 MI TTRUFDT DMMC0I7 MN 5-HT 5A receptor (HTR5A) DMMC0I7 MT DTT DMMC0I7 MA Inhibitor DMMC0I7 RN Higher-end serotonin receptors: 5-HT(5), 5-HT(6), and 5-HT(7). J Med Chem. 2003 Jul 3;46(14):2795-812. DMMC0I7 RU https://pubmed.ncbi.nlm.nih.gov/12825922 DMMC0I7 DI DMMC0I7 DMMC0I7 DN METHIOTHEPIN DMMC0I7 MI TTJS8PY DMMC0I7 MN 5-HT 6 receptor (HTR6) DMMC0I7 MT DTT DMMC0I7 MA Inhibitor DMMC0I7 RN 5-Cyclic amine-3-arylsulfonylindazoles as novel 5-HT6 receptor antagonists. J Med Chem. 2010 Mar 25;53(6):2521-7. DMMC0I7 RU https://pubmed.ncbi.nlm.nih.gov/20170099 DMMC0I7 DI DMMC0I7 DMMC0I7 DN METHIOTHEPIN DMMC0I7 MI TTO9X1H DMMC0I7 MN 5-HT 7 receptor (HTR7) DMMC0I7 MT DTT DMMC0I7 MA Inhibitor DMMC0I7 RN Novel quinazolinone derivatives as 5-HT7 receptor ligands. Bioorg Med Chem. 2008 Mar 1;16(5):2570-8. DMMC0I7 RU https://pubmed.ncbi.nlm.nih.gov/18083580 DMH2CKX DI DMH2CKX DMH2CKX DN METHOCTRAMINE DMH2CKX MI TTJFY5U DMH2CKX MN Adenosine A3 receptor (ADORA3) DMH2CKX MT DTT DMH2CKX MA Inhibitor DMH2CKX RN 2-n-Butyl-9-methyl-8-[1,2,3]triazol-2-yl-9H-purin-6-ylamine and analogues as A2A adenosine receptor antagonists. Design, synthesis, and pharmacolog... J Med Chem. 2005 Nov 3;48(22):6887-96. DMH2CKX RU https://pubmed.ncbi.nlm.nih.gov/16250647 DMH2CKX DI DMH2CKX DMH2CKX DN METHOCTRAMINE DMH2CKX MI TTYEG6Q DMH2CKX MN Muscarinic acetylcholine receptor M2 (CHRM2) DMH2CKX MT DTT DMH2CKX MA Inhibitor DMH2CKX RN cis-4-(Piperazin-1-yl)-5,6,7a,8,9,10,11,11a-octahydrobenzofuro[2,3-h]quinazolin-2-amine (A-987306), a new histamine H4R antagonist that blocks pain... J Med Chem. 2008 Nov 27;51(22):7094-8. DMH2CKX RU https://pubmed.ncbi.nlm.nih.gov/18983139 DM58A0W DI DM58A0W DM58A0W DN methoprene acid DM58A0W MI TT6PEUO DM58A0W MN Retinoic acid receptor RXR-alpha (RXRA) DM58A0W MT DTT DM58A0W MA Agonist DM58A0W RN Activation of mammalian retinoid X receptors by the insect growth regulator methoprene. Proc Natl Acad Sci U S A. 1995 Jun 20;92(13):6157-60. DM58A0W RU https://pubmed.ncbi.nlm.nih.gov/7597096 DM8P526 DI DM8P526 DM8P526 DN Methotrexate gamma-hydroxamic acid DM8P526 MI TTLM12X DM8P526 MN Matrix metalloproteinase-2 (MMP-2) DM8P526 MT DTT DM8P526 MA Inhibitor DM8P526 RN Methotrexate gamma-hydroxamate derivatives as potential dual target antitumor drugs. Bioorg Med Chem. 2007 Feb 1;15(3):1266-74. DM8P526 RU https://pubmed.ncbi.nlm.nih.gov/17127067 DM8P526 DI DM8P526 DM8P526 DN Methotrexate gamma-hydroxamic acid DM8P526 MI TT6X50U DM8P526 MN Matrix metalloproteinase-9 (MMP-9) DM8P526 MT DTT DM8P526 MA Inhibitor DM8P526 RN Methotrexate gamma-hydroxamate derivatives as potential dual target antitumor drugs. Bioorg Med Chem. 2007 Feb 1;15(3):1266-74. DM8P526 RU https://pubmed.ncbi.nlm.nih.gov/17127067 DMELK2A DI DMELK2A DMELK2A DN Methotrexate gamma-L-phenylalaninehydroxamic acid DMELK2A MI TT6X50U DMELK2A MN Matrix metalloproteinase-9 (MMP-9) DMELK2A MT DTT DMELK2A MA Inhibitor DMELK2A RN Methotrexate gamma-hydroxamate derivatives as potential dual target antitumor drugs. Bioorg Med Chem. 2007 Feb 1;15(3):1266-74. DMELK2A RU https://pubmed.ncbi.nlm.nih.gov/17127067 DMPYJLA DI DMPYJLA DMPYJLA DN Methotrexate gamma-L-proline-hydroxamic acid DMPYJLA MI TTLM12X DMPYJLA MN Matrix metalloproteinase-2 (MMP-2) DMPYJLA MT DTT DMPYJLA MA Inhibitor DMPYJLA RN Methotrexate gamma-hydroxamate derivatives as potential dual target antitumor drugs. Bioorg Med Chem. 2007 Feb 1;15(3):1266-74. DMPYJLA RU https://pubmed.ncbi.nlm.nih.gov/17127067 DMPYJLA DI DMPYJLA DMPYJLA DN Methotrexate gamma-L-proline-hydroxamic acid DMPYJLA MI TT6X50U DMPYJLA MN Matrix metalloproteinase-9 (MMP-9) DMPYJLA MT DTT DMPYJLA MA Inhibitor DMPYJLA RN Methotrexate gamma-hydroxamate derivatives as potential dual target antitumor drugs. Bioorg Med Chem. 2007 Feb 1;15(3):1266-74. DMPYJLA RU https://pubmed.ncbi.nlm.nih.gov/17127067 DMX8QK0 DI DMX8QK0 DMX8QK0 DN Methoxy arachidonyl fluorophosphonate DMX8QK0 MI TTDP1UC DMX8QK0 MN Fatty acid amide hydrolase (FAAH) DMX8QK0 MT DTT DMX8QK0 MA Inhibitor DMX8QK0 RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMX8QK0 RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMN8HRU DI DMN8HRU DMN8HRU DN Methoxyphenamine DMN8HRU MI DECB0K3 DMN8HRU MN Cytochrome P450 2D6 (CYP2D6) DMN8HRU MT DME DMN8HRU MA Metabolism DMN8HRU RN Metabolism of methoxyphenamine and 2-methoxyamphetamine in P4502D6-transfected cells and cell preparations. Xenobiotica. 1995 Sep;25(9):895-906. DMN8HRU RU https://www.ncbi.nlm.nih.gov/pubmed/?term=8553683 DMY0O7X DI DMY0O7X DMY0O7X DN METHOXYUNDECYLPHOSPHINIC ACID DMY0O7X MI TTXMY0J DMY0O7X MN Pancreatic triacylglycerol lipase (PNLIP) DMY0O7X MT DTT DMY0O7X MA Inhibitor DMY0O7X RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DMY0O7X RU https://pubmed.ncbi.nlm.nih.gov/10592235 DMGYZHU DI DMGYZHU DMGYZHU DN Methyl 10H-phenothiazine-10-carboxylate DMGYZHU MI TTEB0GD DMGYZHU MN Cholinesterase (BCHE) DMGYZHU MT DTT DMGYZHU MA Inhibitor DMGYZHU RN Carbamates with differential mechanism of inhibition toward acetylcholinesterase and butyrylcholinesterase. J Med Chem. 2008 Jul 24;51(14):4200-12. DMGYZHU RU https://pubmed.ncbi.nlm.nih.gov/18570368 DMV1AL5 DI DMV1AL5 DMV1AL5 DN Methyl 14-(3-n-butylureido)tetradec-8(Z)-enoate DMV1AL5 MI TT7WVHI DMV1AL5 MN Soluble epoxide hydrolase (EPHX2) DMV1AL5 MT DTT DMV1AL5 MA Inhibitor DMV1AL5 RN 14,15-Epoxyeicosa-5,8,11-trienoic acid (14,15-EET) surrogates containing epoxide bioisosteres: influence upon vascular relaxation and soluble epoxi... J Med Chem. 2009 Aug 27;52(16):5069-75. DMV1AL5 RU https://pubmed.ncbi.nlm.nih.gov/19653681 DMBKU9M DI DMBKU9M DMBKU9M DN Methyl 2-(2-oxo-8-phenyloctanamido)acetate DMBKU9M MI TTT1JVS DMBKU9M MN Cytosolic phospholipase A2 (GIVA cPLA2) DMBKU9M MT DTT DMBKU9M MA Inhibitor DMBKU9M RN Structure-activity relationships of natural and non-natural amino acid-based amide and 2-oxoamide inhibitors of human phospholipase A(2) enzymes. Bioorg Med Chem. 2008 Dec 15;16(24):10257-69. DMBKU9M RU https://pubmed.ncbi.nlm.nih.gov/18993078 DMVYGBU DI DMVYGBU DMVYGBU DN Methyl 2-(2-oxohexadecanamido)acetate DMVYGBU MI TTT1JVS DMVYGBU MN Cytosolic phospholipase A2 (GIVA cPLA2) DMVYGBU MT DTT DMVYGBU MA Inhibitor DMVYGBU RN Structure-activity relationships of natural and non-natural amino acid-based amide and 2-oxoamide inhibitors of human phospholipase A(2) enzymes. Bioorg Med Chem. 2008 Dec 15;16(24):10257-69. DMVYGBU RU https://pubmed.ncbi.nlm.nih.gov/18993078 DMA82IQ DI DMA82IQ DMA82IQ DN Methyl 2-(4-chloro-2-cyclohexylphenoxy)acetate DMA82IQ MI TTQDMX5 DMA82IQ MN Prostaglandin D2 receptor 2 (PTGDR2) DMA82IQ MT DTT DMA82IQ MA Inhibitor DMA82IQ RN 2-Cycloalkyl phenoxyacetic acid CRTh2 receptor antagonists. Bioorg Med Chem Lett. 2007 Aug 1;17(15):4347-50. DMA82IQ RU https://pubmed.ncbi.nlm.nih.gov/17531480 DMP06I3 DI DMP06I3 DMP06I3 DN Methyl 2-(7-phenylheptanoyl)oxazole-4-carboxylate DMP06I3 MI TTDP1UC DMP06I3 MN Fatty acid amide hydrolase (FAAH) DMP06I3 MT DTT DMP06I3 MA Inhibitor DMP06I3 RN Exploration of a fundamental substituent effect of alpha-ketoheterocycle enzyme inhibitors: Potent and selective inhibitors of fatty acid amide hyd... Bioorg Med Chem Lett. 2008 Nov 15;18(22):5842-6. DMP06I3 RU https://pubmed.ncbi.nlm.nih.gov/18639454 DM9FA26 DI DM9FA26 DM9FA26 DN Methyl 2-(7-phenylheptanoyl)oxazole-5-carboxylate DM9FA26 MI TTDP1UC DM9FA26 MN Fatty acid amide hydrolase (FAAH) DM9FA26 MT DTT DM9FA26 MA Inhibitor DM9FA26 RN Optimization of the central heterocycle of alpha-ketoheterocycle inhibitors of fatty acid amide hydrolase. J Med Chem. 2008 Aug 14;51(15):4392-403. DM9FA26 RU https://pubmed.ncbi.nlm.nih.gov/18630870 DMB1PXR DI DMB1PXR DMB1PXR DN Methyl 2-(Benzylamino)-1H-indole-3-carboxylate DMB1PXR MI TTSJ6Q4 DMB1PXR MN LOX-5 messenger RNA (ALOX5 mRNA) DMB1PXR MT DTT DMB1PXR MA Inhibitor DMB1PXR RN Structural optimization and biological evaluation of 2-substituted 5-hydroxyindole-3-carboxylates as potent inhibitors of human 5-lipoxygenase. J Med Chem. 2009 Jun 11;52(11):3474-83. DMB1PXR RU https://pubmed.ncbi.nlm.nih.gov/19492852 DMB74WP DI DMB74WP DMB74WP DN Methyl 2-(Diallylamino)-1H-indole-3-carboxylate DMB74WP MI TTSJ6Q4 DMB74WP MN LOX-5 messenger RNA (ALOX5 mRNA) DMB74WP MT DTT DMB74WP MA Inhibitor DMB74WP RN Structural optimization and biological evaluation of 2-substituted 5-hydroxyindole-3-carboxylates as potent inhibitors of human 5-lipoxygenase. J Med Chem. 2009 Jun 11;52(11):3474-83. DMB74WP RU https://pubmed.ncbi.nlm.nih.gov/19492852 DMF6MRS DI DMF6MRS DMF6MRS DN Methyl 2-(naphthalen-2-yl)benzoate DMF6MRS MI TTVBI8W DMF6MRS MN Dopamine transporter (DAT) DMF6MRS MT DTT DMF6MRS MA Inhibitor DMF6MRS RN Synthesis, inhibition and binding of simple non-nitrogen inhibitors of monoamine transporters. Bioorg Med Chem. 2007 Jun 15;15(12):4159-74. DMF6MRS RU https://pubmed.ncbi.nlm.nih.gov/17446076 DMWM814 DI DMWM814 DMWM814 DN Methyl 3-(1-Benzyl-1H-imidazol-5-yl)-propanoate DMWM814 MI TTIQUX7 DMWM814 MN Steroid 11-beta-hydroxylase (CYP11B1) DMWM814 MT DTT DMWM814 MA Inhibitor DMWM814 RN Synthesis, biological evaluation, and molecular modeling of 1-benzyl-1H-imidazoles as selective inhibitors of aldosterone synthase (CYP11B2). J Med Chem. 2010 Feb 25;53(4):1712-25. DMWM814 RU https://pubmed.ncbi.nlm.nih.gov/20121113 DMWG9BE DI DMWG9BE DMWG9BE DN Methyl 3beta-hydroxyolean-12-en-28-oate DMWG9BE MI TTELIN2 DMWG9BE MN PTPN1 messenger RNA (PTPN1 mRNA) DMWG9BE MT DTT DMWG9BE MA Inhibitor DMWG9BE RN Protein tyrosine phosphatase 1B inhibitory activity of triterpenes isolated from Astilbe koreana. Bioorg Med Chem Lett. 2006 Jun 15;16(12):3273-6. DMWG9BE RU https://pubmed.ncbi.nlm.nih.gov/16580200 DM9S210 DI DM9S210 DM9S210 DN Methyl 4-(3-cyclohexylureido)butanoate DM9S210 MI TT7WVHI DM9S210 MN Soluble epoxide hydrolase (EPHX2) DM9S210 MT DTT DM9S210 MA Inhibitor DM9S210 RN Peptidyl-urea based inhibitors of soluble epoxide hydrolases. Bioorg Med Chem Lett. 2006 Oct 15;16(20):5439-44. DM9S210 RU https://pubmed.ncbi.nlm.nih.gov/16908134 DMUROGX DI DMUROGX DMUROGX DN Methyl 4-(4-hydroxybenzylideneamino)benzoate DMUROGX MI TTANPDJ DMUROGX MN Carbonic anhydrase II (CA-II) DMUROGX MT DTT DMUROGX MA Inhibitor DMUROGX RN Carbonic anhydrase II-induced selection of inhibitors from a dynamic combinatorial library of Schiff's bases. Bioorg Med Chem Lett. 2009 Nov 1;19(21):6014-7. DMUROGX RU https://pubmed.ncbi.nlm.nih.gov/19796939 DMSBCL6 DI DMSBCL6 DMSBCL6 DN Methyl 4-(4-tert-butylbenzylideneamino)benzoate DMSBCL6 MI TTANPDJ DMSBCL6 MN Carbonic anhydrase II (CA-II) DMSBCL6 MT DTT DMSBCL6 MA Inhibitor DMSBCL6 RN Carbonic anhydrase II-induced selection of inhibitors from a dynamic combinatorial library of Schiff's bases. Bioorg Med Chem Lett. 2009 Nov 1;19(21):6014-7. DMSBCL6 RU https://pubmed.ncbi.nlm.nih.gov/19796939 DM9BPQ1 DI DM9BPQ1 DM9BPQ1 DN Methyl 6-(3-cyclohexylureido)hexanoate DM9BPQ1 MI TT7WVHI DM9BPQ1 MN Soluble epoxide hydrolase (EPHX2) DM9BPQ1 MT DTT DM9BPQ1 MA Inhibitor DM9BPQ1 RN Peptidyl-urea based inhibitors of soluble epoxide hydrolases. Bioorg Med Chem Lett. 2006 Oct 15;16(20):5439-44. DM9BPQ1 RU https://pubmed.ncbi.nlm.nih.gov/16908134 DMBLW1A DI DMBLW1A DMBLW1A DN Methyl 7-methoxy-4-phenylbenzofuran-2-ylcarbamate DMBLW1A MI TTM2AOE DMBLW1A MN Adenosine A2a receptor (ADORA2A) DMBLW1A MT DTT DMBLW1A MA Inhibitor DMBLW1A RN Synthetic studies on selective adenosine A2A receptor antagonists: synthesis and structure-activity relationships of novel benzofuran derivatives. Bioorg Med Chem Lett. 2010 Feb 1;20(3):1090-3. DMBLW1A RU https://pubmed.ncbi.nlm.nih.gov/20034788 DM9HLXD DI DM9HLXD DM9HLXD DN Methyl 7-tert-butyl-9H-carbazole-3-carboxylate DM9HLXD MI TTBGTCW DM9HLXD MN Kinesin spindle messenger RNA (KIF11 mRNA) DM9HLXD MT DTT DM9HLXD MA Inhibitor DM9HLXD RN Kinesin spindle protein (KSP) inhibitors with 2,3-fused indole scaffolds. J Med Chem. 2010 Jul 8;53(13):5054-8. DM9HLXD RU https://pubmed.ncbi.nlm.nih.gov/20521839 DM4DIS3 DI DM4DIS3 DM4DIS3 DN Methyl 9H-carbazole-2-carboxylate DM4DIS3 MI TTBGTCW DM4DIS3 MN Kinesin spindle messenger RNA (KIF11 mRNA) DM4DIS3 MT DTT DM4DIS3 MA Inhibitor DM4DIS3 RN Kinesin spindle protein (KSP) inhibitors with 2,3-fused indole scaffolds. J Med Chem. 2010 Jul 8;53(13):5054-8. DM4DIS3 RU https://pubmed.ncbi.nlm.nih.gov/20521839 DMAXEH3 DI DMAXEH3 DMAXEH3 DN Methyl arachidonyl fluorophosphonate DMAXEH3 MI TTT1JVS DMAXEH3 MN Cytosolic phospholipase A2 (GIVA cPLA2) DMAXEH3 MT DTT DMAXEH3 MA Inhibitor DMAXEH3 RN 85-kDa cPLA(2) plays a critical role in PPAR-mediated gene transcription in human hepatoma cells. Am J Physiol Gastrointest Liver Physiol. 2002 Apr;282(4):G586-97. DMAXEH3 RU https://pubmed.ncbi.nlm.nih.gov/11897617 DMG8XD1 DI DMG8XD1 DMG8XD1 DN Methyl estradiol-16-beta-carboxylate DMG8XD1 MI TTIWB6L DMG8XD1 MN Estradiol 17 beta-dehydrogenase 1 (17-beta-HSD1) DMG8XD1 MT DTT DMG8XD1 MA Inhibitor DMG8XD1 RN Modification of estrone at the 6, 16, and 17 positions: novel potent inhibitors of 17beta-hydroxysteroid dehydrogenase type 1. J Med Chem. 2006 Feb 23;49(4):1325-45. DMG8XD1 RU https://pubmed.ncbi.nlm.nih.gov/16480268 DM9O5S6 DI DM9O5S6 DM9O5S6 DN Methyl icosylphosphonofluoridate DM9O5S6 MI TT6OEDT DM9O5S6 MN Cannabinoid receptor 1 (CB1) DM9O5S6 MT DTT DM9O5S6 MA Inhibitor DM9O5S6 RN Monoacylglycerol lipase regulates 2-arachidonoylglycerol action and arachidonic acid levels. Bioorg Med Chem Lett. 2008 Nov 15;18(22):5875-8. DM9O5S6 RU https://pubmed.ncbi.nlm.nih.gov/18752948 DM9O5S6 DI DM9O5S6 DM9O5S6 DN Methyl icosylphosphonofluoridate DM9O5S6 MI TTDP1UC DM9O5S6 MN Fatty acid amide hydrolase (FAAH) DM9O5S6 MT DTT DM9O5S6 MA Inhibitor DM9O5S6 RN Monoacylglycerol lipase regulates 2-arachidonoylglycerol action and arachidonic acid levels. Bioorg Med Chem Lett. 2008 Nov 15;18(22):5875-8. DM9O5S6 RU https://pubmed.ncbi.nlm.nih.gov/18752948 DME4JGF DI DME4JGF DME4JGF DN methyl isocyanate DME4JGF MI TTELV3W DME4JGF MN Transformation-sensitive protein p120 (TRPA1) DME4JGF MT DTT DME4JGF MA Activator DME4JGF RN Transient receptor potential ankyrin 1 antagonists block the noxious effects of toxic industrial isocyanates and tear gases. FASEB J. 2009 Apr;23(4):1102-14. DME4JGF RU https://pubmed.ncbi.nlm.nih.gov/19036859 DMBHUKV DI DMBHUKV DMBHUKV DN Methyl L-phenylalaninate DMBHUKV MI TT6L509 DMBHUKV MN Coagulation factor IIa (F2) DMBHUKV MT DTT DMBHUKV MA Inhibitor DMBHUKV RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DMBHUKV RU https://pubmed.ncbi.nlm.nih.gov/10592235 DM6YEW4 DI DM6YEW4 DM6YEW4 DN Methyl Mercury Ion DM6YEW4 MI TTANPDJ DM6YEW4 MN Carbonic anhydrase II (CA-II) DM6YEW4 MT DTT DM6YEW4 MA Inhibitor DM6YEW4 RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DM6YEW4 RU https://pubmed.ncbi.nlm.nih.gov/17139284 DM6YEW4 DI DM6YEW4 DM6YEW4 DN Methyl Mercury Ion DM6YEW4 MI TTR0SWN DM6YEW4 MN M-phase inducer phosphatase 2 (MPIP2) DM6YEW4 MT DTT DM6YEW4 MA Inhibitor DM6YEW4 RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DM6YEW4 RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMOCXLW DI DMOCXLW DMOCXLW DN Methyl Methylsulfinylmethyl Sulfide DMOCXLW MI TTMW94E DMOCXLW MN FK506-binding protein 1A (FKBP1A) DMOCXLW MT DTT DMOCXLW MA Inhibitor DMOCXLW RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMOCXLW RU https://pubmed.ncbi.nlm.nih.gov/17139284 DM096SI DI DM096SI DM096SI DN Methyl Phosphinic Acid DM096SI MI TT1RS9F DM096SI MN Acetylcholinesterase (AChE) DM096SI MT DTT DM096SI MA Inhibitor DM096SI RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DM096SI RU https://pubmed.ncbi.nlm.nih.gov/17139284 DM096SI DI DM096SI DM096SI DN Methyl Phosphinic Acid DM096SI MI TTEB0GD DM096SI MN Cholinesterase (BCHE) DM096SI MT DTT DM096SI MA Inhibitor DM096SI RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DM096SI RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMO58UW DI DMO58UW DMO58UW DN methyl p-hydroxybenzoate DMO58UW MI TTELV3W DMO58UW MN Transformation-sensitive protein p120 (TRPA1) DMO58UW MT DTT DMO58UW MA Activator DMO58UW RN Methyl p-hydroxybenzoate causes pain sensation through activation of TRPA1 channels. Br J Pharmacol. 2007 May;151(1):153-60. DMO58UW RU https://pubmed.ncbi.nlm.nih.gov/17351650 DMW2R3M DI DMW2R3M DMW2R3M DN Methyl piperate DMW2R3M MI TTGP7BY DMW2R3M MN Monoamine oxidase type B (MAO-B) DMW2R3M MT DTT DMW2R3M MA Inhibitor DMW2R3M RN Proposed structural basis of interaction of piperine and related compounds with monoamine oxidases. Bioorg Med Chem Lett. 2010 Jan 15;20(2):537-40. DMW2R3M RU https://pubmed.ncbi.nlm.nih.gov/19969454 DMKCG8H DI DMKCG8H DMKCG8H DN methyl salicylate DMKCG8H MI TTELV3W DMKCG8H MN Transformation-sensitive protein p120 (TRPA1) DMKCG8H MT DTT DMKCG8H MA Activator DMKCG8H RN Noxious cold ion channel TRPA1 is activated by pungent compounds and bradykinin. Neuron. 2004 Mar 25;41(6):849-57. DMKCG8H RU https://pubmed.ncbi.nlm.nih.gov/15046718 DM9Y4FL DI DM9Y4FL DM9Y4FL DN Methyl-(1,2,3,4-tetrahydro-naphthalen-1-yl)-amine DM9Y4FL MI TTGP7BY DM9Y4FL MN Monoamine oxidase type B (MAO-B) DM9Y4FL MT DTT DM9Y4FL MA Inhibitor DM9Y4FL RN Stereoisomers of allenic amines as inactivators of monoamine oxidase type B. Stereochemical probes of the active site. J Med Chem. 1988 Aug;31(8):1558-66. DM9Y4FL RU https://pubmed.ncbi.nlm.nih.gov/3397993 DMQU9VD DI DMQU9VD DMQU9VD DN Methyl-(5-pyridin-3-yl-thiophen-2-yl)-amine DMQU9VD MI TTXV4FI DMQU9VD MN Albendazole monooxygenase (CYP3A4) DMQU9VD MT DTT DMQU9VD MA Inhibitor DMQU9VD RN 5-substituted, 6-substituted, and unsubstituted 3-heteroaromatic pyridine analogues of nicotine as selective inhibitors of cytochrome P-450 2A6. J Med Chem. 2005 Jan 13;48(1):224-39. DMQU9VD RU https://pubmed.ncbi.nlm.nih.gov/15634016 DMQU9VD DI DMQU9VD DMQU9VD DN Methyl-(5-pyridin-3-yl-thiophen-2-yl)-amine DMQU9VD MI TTVG215 DMQU9VD MN Debrisoquine 4-hydroxylase (CYP2D6) DMQU9VD MT DTT DMQU9VD MA Inhibitor DMQU9VD RN 5-substituted, 6-substituted, and unsubstituted 3-heteroaromatic pyridine analogues of nicotine as selective inhibitors of cytochrome P-450 2A6. J Med Chem. 2005 Jan 13;48(1):224-39. DMQU9VD RU https://pubmed.ncbi.nlm.nih.gov/15634016 DMZVBLT DI DMZVBLT DMZVBLT DN Methyl[4'-(trifluoromethyl)-4-biphenylyl]amine DMZVBLT MI TTBGTCW DMZVBLT MN Kinesin spindle messenger RNA (KIF11 mRNA) DMZVBLT MT DTT DMZVBLT MA Inhibitor DMZVBLT RN Novel ATP-competitive kinesin spindle protein inhibitors. J Med Chem. 2007 Oct 4;50(20):4939-52. DMZVBLT RU https://pubmed.ncbi.nlm.nih.gov/17725339 DMOA54M DI DMOA54M DMOA54M DN Methyl3beta-hydroxyolean-12-en-27-oate DMOA54M MI TTELIN2 DMOA54M MN PTPN1 messenger RNA (PTPN1 mRNA) DMOA54M MT DTT DMOA54M MA Inhibitor DMOA54M RN Protein tyrosine phosphatase 1B inhibitory activity of triterpenes isolated from Astilbe koreana. Bioorg Med Chem Lett. 2006 Jun 15;16(12):3273-6. DMOA54M RU https://pubmed.ncbi.nlm.nih.gov/16580200 DMTPL4W DI DMTPL4W DMTPL4W DN Methylamine DMTPL4W MI DE6SOC5 DMTPL4W MN Copper amine oxidase (AOC3) DMTPL4W MT DME DMTPL4W MA Metabolism DMTPL4W RN The unique substrate specificity of human AOC2, a semicarbazide-sensitive amine oxidase. Cell Mol Life Sci. 2009 Aug;66(16):2743-57. DMTPL4W RU https://www.ncbi.nlm.nih.gov/pubmed/?term=19588076 DMTPL4W DI DMTPL4W DMTPL4W DN Methylamine DMTPL4W MI DE8DP90 DMTPL4W MN Semicarbazide-sensitive amine oxidase (AOC2) DMTPL4W MT DME DMTPL4W MA Metabolism DMTPL4W RN The unique substrate specificity of human AOC2, a semicarbazide-sensitive amine oxidase. Cell Mol Life Sci. 2009 Aug;66(16):2743-57. DMTPL4W RU https://www.ncbi.nlm.nih.gov/pubmed/?term=19588076 DM9JECY DI DM9JECY DM9JECY DN METHYLAMINO-PHENYLALANYL-LEUCYL-HYDROXAMIC ACID DM9JECY MI TTMX39J DM9JECY MN Matrix metalloproteinase-1 (MMP-1) DM9JECY MT DTT DM9JECY MA Inhibitor DM9JECY RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DM9JECY RU https://pubmed.ncbi.nlm.nih.gov/10592235 DM9JECY DI DM9JECY DM9JECY DN METHYLAMINO-PHENYLALANYL-LEUCYL-HYDROXAMIC ACID DM9JECY MI TTGA1IV DM9JECY MN Matrix metalloproteinase-8 (MMP-8) DM9JECY MT DTT DM9JECY MA Inhibitor DM9JECY RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DM9JECY RU https://pubmed.ncbi.nlm.nih.gov/10592235 DMDP84X DI DMDP84X DMDP84X DN Methylcarbamic Acid Biphenyl-3-yl Ester DMDP84X MI TTDP1UC DMDP84X MN Fatty acid amide hydrolase (FAAH) DMDP84X MT DTT DMDP84X MA Inhibitor DMDP84X RN Synthesis and quantitative structure-activity relationship of fatty acid amide hydrolase inhibitors: modulation at the N-portion of biphenyl-3-yl a... J Med Chem. 2008 Jun 26;51(12):3487-98. DMDP84X RU https://pubmed.ncbi.nlm.nih.gov/18507372 DMV865Q DI DMV865Q DMV865Q DN methylcarbamyl PAF DMV865Q MI TTQL5VC DMV865Q MN Platelet-activating factor receptor (PTAFR) DMV865Q MT DTT DMV865Q MA Agonist DMV865Q RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 334). DMV865Q RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=334 DMP204G DI DMP204G DMP204G DN Methylenedioxyamphetamine DMP204G MI TTVBI8W DMP204G MN Dopamine transporter (DAT) DMP204G MT DTT DMP204G MA Inhibitor DMP204G RN Synthesis and in vitro toxicity of 4-MTA, its characteristic clandestine synthesis byproducts and related sulfur substituted alpha-alkylthioampheta... Bioorg Med Chem. 2010 Jun 1;18(11):4009-31. DMP204G RU https://pubmed.ncbi.nlm.nih.gov/20466553 DMP204G DI DMP204G DMP204G DN Methylenedioxyamphetamine DMP204G MI TTAWNKZ DMP204G MN Norepinephrine transporter (NET) DMP204G MT DTT DMP204G MA Inhibitor DMP204G RN Synthesis and in vitro toxicity of 4-MTA, its characteristic clandestine synthesis byproducts and related sulfur substituted alpha-alkylthioampheta... Bioorg Med Chem. 2010 Jun 1;18(11):4009-31. DMP204G RU https://pubmed.ncbi.nlm.nih.gov/20466553 DMP204G DI DMP204G DMP204G DN Methylenedioxyamphetamine DMP204G MI TT3ROYC DMP204G MN Serotonin transporter (SERT) DMP204G MT DTT DMP204G MA Inhibitor DMP204G RN Synthesis and serotonin transporter activity of sulphur-substituted alpha-alkyl phenethylamines as a new class of anticancer agents. Eur J Med Chem. 2009 Dec;44(12):4862-88. DMP204G RU https://pubmed.ncbi.nlm.nih.gov/19717215 DMYVU47 DI DMYVU47 DMYVU47 DN Methylenedioxymethamphetamine DMYVU47 MI TTJQOD7 DMYVU47 MN 5-HT 2A receptor (HTR2A) DMYVU47 MT DTT DMYVU47 MA Agonist DMYVU47 RN The origin of MDMA (ecstasy) revisited: the true story reconstructed from the original documents. Addiction. 2006 Sep;101(9):1241-5. DMYVU47 RU https://pubmed.ncbi.nlm.nih.gov/16911722 DMYVU47 DI DMYVU47 DMYVU47 DN Methylenedioxymethamphetamine DMYVU47 MI TT0K1SC DMYVU47 MN 5-HT 2B receptor (HTR2B) DMYVU47 MT DTT DMYVU47 MA Agonist DMYVU47 RN The origin of MDMA (ecstasy) revisited: the true story reconstructed from the original documents. Addiction. 2006 Sep;101(9):1241-5. DMYVU47 RU https://pubmed.ncbi.nlm.nih.gov/16911722 DMYVU47 DI DMYVU47 DMYVU47 DN Methylenedioxymethamphetamine DMYVU47 MI TTWJBZ5 DMYVU47 MN 5-HT 2C receptor (HTR2C) DMYVU47 MT DTT DMYVU47 MA Agonist DMYVU47 RN The origin of MDMA (ecstasy) revisited: the true story reconstructed from the original documents. Addiction. 2006 Sep;101(9):1241-5. DMYVU47 RU https://pubmed.ncbi.nlm.nih.gov/16911722 DMYVU47 DI DMYVU47 DMYVU47 DN Methylenedioxymethamphetamine DMYVU47 MI DEV3T4A DMYVU47 MN Catechol O-methyltransferase (COMT) DMYVU47 MT DME DMYVU47 MA Metabolism DMYVU47 RN Human pharmacology of MDMA: pharmacokinetics, metabolism, and disposition. Ther Drug Monit. 2004 Apr;26(2):137-44. DMYVU47 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=15228154 DMYVU47 DI DMYVU47 DMYVU47 DN Methylenedioxymethamphetamine DMYVU47 MI DE4OGUF DMYVU47 MN Cytochrome P450 102A1 (cyp102) DMYVU47 MT DME DMYVU47 MA Metabolism DMYVU47 RN The bacterial P450 BM3: a prototype for a biocatalyst with human P450 activities. Trends Biotechnol. 2007 Jul;25(7):289-98. DMYVU47 RU https://pubmed.ncbi.nlm.nih.gov/17532492 DMYVU47 DI DMYVU47 DMYVU47 DN Methylenedioxymethamphetamine DMYVU47 MI DECB0K3 DMYVU47 MN Cytochrome P450 2D6 (CYP2D6) DMYVU47 MT DME DMYVU47 MA Metabolism DMYVU47 RN Human pharmacology of MDMA: pharmacokinetics, metabolism, and disposition. Ther Drug Monit. 2004 Apr;26(2):137-44. DMYVU47 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=15228154 DMYVU47 DI DMYVU47 DMYVU47 DN Methylenedioxymethamphetamine DMYVU47 MI TTVBI8W DMYVU47 MN Dopamine transporter (DAT) DMYVU47 MT DTT DMYVU47 MA Inhibitor DMYVU47 RN The origin of MDMA (ecstasy) revisited: the true story reconstructed from the original documents. Addiction. 2006 Sep;101(9):1241-5. DMYVU47 RU https://pubmed.ncbi.nlm.nih.gov/16911722 DMYVU47 DI DMYVU47 DMYVU47 DN Methylenedioxymethamphetamine DMYVU47 MI TTAWNKZ DMYVU47 MN Norepinephrine transporter (NET) DMYVU47 MT DTT DMYVU47 MA Inhibitor DMYVU47 RN The origin of MDMA (ecstasy) revisited: the true story reconstructed from the original documents. Addiction. 2006 Sep;101(9):1241-5. DMYVU47 RU https://pubmed.ncbi.nlm.nih.gov/16911722 DMYVU47 DI DMYVU47 DMYVU47 DN Methylenedioxymethamphetamine DMYVU47 MI TT3ROYC DMYVU47 MN Serotonin transporter (SERT) DMYVU47 MT DTT DMYVU47 MA Inhibitor DMYVU47 RN The origin of MDMA (ecstasy) revisited: the true story reconstructed from the original documents. Addiction. 2006 Sep;101(9):1241-5. DMYVU47 RU https://pubmed.ncbi.nlm.nih.gov/16911722 DMYVU47 DI DMYVU47 DMYVU47 DN Methylenedioxymethamphetamine DMYVU47 MI TTNZRI3 DMYVU47 MN Synaptic vesicle amine transporter (SLC18A2) DMYVU47 MT DTT DMYVU47 MA Antagonist DMYVU47 RN The origin of MDMA (ecstasy) revisited: the true story reconstructed from the original documents. Addiction. 2006 Sep;101(9):1241-5. DMYVU47 RU https://pubmed.ncbi.nlm.nih.gov/16911722 DMZ318I DI DMZ318I DMZ318I DN methylfurmethide DMZ318I MI TTOXS3C DMZ318I MN Muscarinic acetylcholine receptor (CHRM) DMZ318I MT DTT DMZ318I MA Agonist DMZ318I RN Positive cooperativity of acetylcholine and other agonists with allosteric ligands on muscarinic acetylcholine receptors. Mol Pharmacol. 1997 Jul;52(1):172-9. DMZ318I RU https://pubmed.ncbi.nlm.nih.gov/9224827 DMZ318I DI DMZ318I DMZ318I DN methylfurmethide DMZ318I MI TTQ13Z5 DMZ318I MN Muscarinic acetylcholine receptor M3 (CHRM3) DMZ318I MT DTT DMZ318I MA Agonist DMZ318I RN Positive cooperativity of acetylcholine and other agonists with allosteric ligands on muscarinic acetylcholine receptors. Mol Pharmacol. 1997 Jul;52(1):172-9. DMZ318I RU https://pubmed.ncbi.nlm.nih.gov/9224827 DMUBY4J DI DMUBY4J DMUBY4J DN Methylglyoxal DMUBY4J MI DE05IKP DMUBY4J MN Hydroxyacylglutathione hydrolase (HAGH) DMUBY4J MT DME DMUBY4J MA Metabolism DMUBY4J RN Weak association of glyoxalase 1 (GLO1) variants with autism spectrum disorder. Eur Child Adolesc Psychiatry. 2015 Jan;24(1):75-82. DMUBY4J RU https://pubmed.ncbi.nlm.nih.gov/24671236 DMRC3OZ DI DMRC3OZ DMRC3OZ DN methylglyoxal DMRC3OZ MI TT9V5JH DMRC3OZ MN Phospholipase A2 (PLA2G1B) DMRC3OZ MT DTT DMRC3OZ MA Inhibitor DMRC3OZ RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMRC3OZ RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMRC3OZ DI DMRC3OZ DMRC3OZ DN methylglyoxal DMRC3OZ MI TTELV3W DMRC3OZ MN Transformation-sensitive protein p120 (TRPA1) DMRC3OZ MT DTT DMRC3OZ MA Activator DMRC3OZ RN Inhibiting TRPA1 ion channel reduces loss of cutaneous nerve fiber function in diabetic animals: sustained activation of the TRPA1 channel contributes to the pathogenesis of peripheral diabetic neuropathy. Pharmacol Res. 2012 Jan;65(1):149-58. DMRC3OZ RU https://pubmed.ncbi.nlm.nih.gov/22133672 DM7PRDY DI DM7PRDY DM7PRDY DN methylhistaprodifen DM7PRDY MI TTTIBOJ DM7PRDY MN Histamine H1 receptor (H1R) DM7PRDY MT DTT DM7PRDY MA Agonist DM7PRDY RN Multiple differences in agonist and antagonist pharmacology between human and guinea pig histamine H1-receptor. J Pharmacol Exp Ther. 2003 Jun;305(3):1104-15. DM7PRDY RU https://pubmed.ncbi.nlm.nih.gov/12626648 DM9YE6K DI DM9YE6K DM9YE6K DN METHYLHONOKIOL DM9YE6K MI TTSJ6Q4 DM9YE6K MN LOX-5 messenger RNA (ALOX5 mRNA) DM9YE6K MT DTT DM9YE6K MA Inhibitor DM9YE6K RN Design and synthesis of ten biphenyl-neolignan derivatives and their in vitro inhibitory potency against cyclooxygenase-1/2 activity and 5-lipoxyge... Bioorg Med Chem. 2009 Jul 1;17(13):4459-65. DM9YE6K RU https://pubmed.ncbi.nlm.nih.gov/19481465 DM9YE6K DI DM9YE6K DM9YE6K DN METHYLHONOKIOL DM9YE6K MI TT8NGED DM9YE6K MN Prostaglandin G/H synthase 1 (COX-1) DM9YE6K MT DTT DM9YE6K MA Inhibitor DM9YE6K RN Design and synthesis of ten biphenyl-neolignan derivatives and their in vitro inhibitory potency against cyclooxygenase-1/2 activity and 5-lipoxyge... Bioorg Med Chem. 2009 Jul 1;17(13):4459-65. DM9YE6K RU https://pubmed.ncbi.nlm.nih.gov/19481465 DM9YE6K DI DM9YE6K DM9YE6K DN METHYLHONOKIOL DM9YE6K MI TTVKILB DM9YE6K MN Prostaglandin G/H synthase 2 (COX-2) DM9YE6K MT DTT DM9YE6K MA Inhibitor DM9YE6K RN Design and synthesis of ten biphenyl-neolignan derivatives and their in vitro inhibitory potency against cyclooxygenase-1/2 activity and 5-lipoxyge... Bioorg Med Chem. 2009 Jul 1;17(13):4459-65. DM9YE6K RU https://pubmed.ncbi.nlm.nih.gov/19481465 DMOWMPL DI DMOWMPL DMOWMPL DN METHYLNORADRENALINE DMOWMPL MI TTWG9A4 DMOWMPL MN Adrenergic receptor alpha-2A (ADRA2A) DMOWMPL MT DTT DMOWMPL MA Inhibitor DMOWMPL RN alpha 2 adrenoceptors: classification, localization, mechanisms, and targets for drugs. J Med Chem. 1982 Dec;25(12):1389-401. DMOWMPL RU https://pubmed.ncbi.nlm.nih.gov/6296387 DMOWMPL DI DMOWMPL DMOWMPL DN METHYLNORADRENALINE DMOWMPL MI TTWM4TY DMOWMPL MN Adrenergic receptor alpha-2B (ADRA2B) DMOWMPL MT DTT DMOWMPL MA Inhibitor DMOWMPL RN alpha 2 adrenoceptors: classification, localization, mechanisms, and targets for drugs. J Med Chem. 1982 Dec;25(12):1389-401. DMOWMPL RU https://pubmed.ncbi.nlm.nih.gov/6296387 DMOWMPL DI DMOWMPL DMOWMPL DN METHYLNORADRENALINE DMOWMPL MI TT2NUT5 DMOWMPL MN Adrenergic receptor alpha-2C (ADRA2C) DMOWMPL MT DTT DMOWMPL MA Inhibitor DMOWMPL RN alpha 2 adrenoceptors: classification, localization, mechanisms, and targets for drugs. J Med Chem. 1982 Dec;25(12):1389-401. DMOWMPL RU https://pubmed.ncbi.nlm.nih.gov/6296387 DMQ7THK DI DMQ7THK DMQ7THK DN Methyl-pentyl-prop-2-ynyl-amine oxalic acid DMQ7THK MI TTGP7BY DMQ7THK MN Monoamine oxidase type B (MAO-B) DMQ7THK MT DTT DMQ7THK MA Inhibitor DMQ7THK RN Aliphatic propargylamines: potent, selective, irreversible monoamine oxidase B inhibitors. J Med Chem. 1992 Oct 2;35(20):3705-13. DMQ7THK RU https://pubmed.ncbi.nlm.nih.gov/1433183 DMR7HV3 DI DMR7HV3 DMR7HV3 DN METHYL-PHE-PRO-AMINO-CYCLOHEXYLGLYCINE DMR7HV3 MI TT6L509 DMR7HV3 MN Coagulation factor IIa (F2) DMR7HV3 MT DTT DMR7HV3 MA Inhibitor DMR7HV3 RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DMR7HV3 RU https://pubmed.ncbi.nlm.nih.gov/10592235 DMKTOPJ DI DMKTOPJ DMKTOPJ DN methyl-piperidino-pyrazole DMKTOPJ MI TTZAYWL DMKTOPJ MN Estrogen receptor (ESR) DMKTOPJ MT DTT DMKTOPJ MA Antagonist DMKTOPJ RN Antagonists selective for estrogen receptor alpha. Endocrinology. 2002 Mar;143(3):941-7. DMKTOPJ RU https://pubmed.ncbi.nlm.nih.gov/11861516 DMU3JBL DI DMU3JBL DMU3JBL DN Methylthioribose phosphate DMU3JBL MI DES378D DMU3JBL MN Methylthioribose kinase (mtnK) DMU3JBL MT DME DMU3JBL MA Metabolism DMU3JBL RN Selective killing of Klebsiella pneumoniae by 5-trifluoromethylthioribose. Chemotherapeutic exploitation of the enzyme 5-methylthioribose kinase. J Biol Chem. 1990 Jan 15;265(2):831-7. DMU3JBL RU https://pubmed.ncbi.nlm.nih.gov/2153115 DMAEQB6 DI DMAEQB6 DMAEQB6 DN Methylurea DMAEQB6 MI DTMF8LB DMAEQB6 MN Urea transporter 1 (SLC14A1) DMAEQB6 MT DTP DMAEQB6 MA Substrate DMAEQB6 RN Comparative transport efficiencies of urea analogues through urea transporter UT-B. Biochim Biophys Acta. 2007 Jul;1768(7):1815-21. DMAEQB6 RU http://www.ncbi.nlm.nih.gov/pubmed/17506977 DMAEQB6 DI DMAEQB6 DMAEQB6 DN Methylurea DMAEQB6 MI DT8QC7K DMAEQB6 MN Urea transporter 2 (SLC14A2) DMAEQB6 MT DTP DMAEQB6 MA Substrate DMAEQB6 RN Urea transporter physiology studied in knockout mice. Front Physiol. 2012 Jun 26;3:217. DMAEQB6 RU http://www.ncbi.nlm.nih.gov/pubmed/22745630 DMO7JGS DI DMO7JGS DMO7JGS DN Metiamide DMO7JGS MI TTQHJ1K DMO7JGS MN Histamine H2 receptor (H2R) DMO7JGS MT DTT DMO7JGS MA Antagonist DMO7JGS RN Metiamide--an orally active histamine H2-receptor antagonist. 1973. Agents Actions. 1994 Dec;43(3-4):91-5; discussion 96. DMO7JGS RU https://pubmed.ncbi.nlm.nih.gov/7725982 DMZBLQD DI DMZBLQD DMZBLQD DN Met-Lys-bradykinin DMZBLQD MI TTGY8IW DMZBLQD MN B2 bradykinin receptor (BDKRB2) DMZBLQD MT DTT DMZBLQD MA Agonist DMZBLQD RN Expression cloning of a human B1 bradykinin receptor. J Biol Chem. 1994 Aug 26;269(34):21583-6. DMZBLQD RU https://pubmed.ncbi.nlm.nih.gov/8063797 DM70RDZ DI DM70RDZ DM70RDZ DN Metrenperone DM70RDZ MI TTYSN63 DM70RDZ MN 5-HT 2 receptor (5HT2R) DM70RDZ MT DTT DM70RDZ MA Antagonist DM70RDZ RN Cardiovascular response to intravenous administration of 5-hydroxytryptamine after type-2 receptor blockade, by metrenperone, in healthy calves. Vet J. 1999 Jan;157(1):31-7. DM70RDZ RU https://pubmed.ncbi.nlm.nih.gov/10030126 DMGH8WV DI DMGH8WV DMGH8WV DN MeTRH DMGH8WV MI TT4J8MF DMGH8WV MN Thyrotropin-releasing hormone receptor (TRHR) DMGH8WV MT DTT DMGH8WV MA Agonist DMGH8WV RN Thyrotropin-releasing hormone receptor type 1 (TRH-R1), not TRH-R2, primarily mediates taltirelin actions in the CNS of mice. Neuropsychopharmacology. 2013 May;38(6):950-6. DMGH8WV RU https://pubmed.ncbi.nlm.nih.gov/23303050 DMHTGCR DI DMHTGCR DMHTGCR DN METYRAPOL DMHTGCR MI TTIQUX7 DMHTGCR MN Steroid 11-beta-hydroxylase (CYP11B1) DMHTGCR MT DTT DMHTGCR MA Inhibitor DMHTGCR RN Structure-activity relationship study of the inhibition of adrenal cortical 11 beta-hydroxylase by new metyrapone analogues. J Med Chem. 1984 Jan;27(1):15-9. DMHTGCR RU https://pubmed.ncbi.nlm.nih.gov/6606707 DMVYWJS DI DMVYWJS DMVYWJS DN MEZILAMINE DMVYWJS MI TTWG9A4 DMVYWJS MN Adrenergic receptor alpha-2A (ADRA2A) DMVYWJS MT DTT DMVYWJS MA Inhibitor DMVYWJS RN 4-Amino-6-chloro-2-piperazinopyrimidines with selective affinity for alpha 2-adrenoceptors. J Med Chem. 1986 Aug;29(8):1394-8. DMVYWJS RU https://pubmed.ncbi.nlm.nih.gov/3016265 DMVYWJS DI DMVYWJS DMVYWJS DN MEZILAMINE DMVYWJS MI TTWM4TY DMVYWJS MN Adrenergic receptor alpha-2B (ADRA2B) DMVYWJS MT DTT DMVYWJS MA Inhibitor DMVYWJS RN 4-Amino-6-chloro-2-piperazinopyrimidines with selective affinity for alpha 2-adrenoceptors. J Med Chem. 1986 Aug;29(8):1394-8. DMVYWJS RU https://pubmed.ncbi.nlm.nih.gov/3016265 DMVYWJS DI DMVYWJS DMVYWJS DN MEZILAMINE DMVYWJS MI TT2NUT5 DMVYWJS MN Adrenergic receptor alpha-2C (ADRA2C) DMVYWJS MT DTT DMVYWJS MA Inhibitor DMVYWJS RN 4-Amino-6-chloro-2-piperazinopyrimidines with selective affinity for alpha 2-adrenoceptors. J Med Chem. 1986 Aug;29(8):1394-8. DMVYWJS RU https://pubmed.ncbi.nlm.nih.gov/3016265 DMBLUSA DI DMBLUSA DMBLUSA DN MF-152 DMBLUSA MI TT6RIOV DMBLUSA MN Acyl-CoA desaturase (SCD) DMBLUSA MT DTT DMBLUSA MA Inhibitor DMBLUSA RN SAR and optimization of thiazole analogs as potent stearoyl-CoA desaturase inhibitors. Bioorg Med Chem Lett. 2010 Mar 1;20(5):1593-7. DMBLUSA RU https://pubmed.ncbi.nlm.nih.gov/20137926 DMSYQP9 DI DMSYQP9 DMSYQP9 DN MF266-1 DMSYQP9 MI TTG1QMU DMSYQP9 MN Prostaglandin E2 receptor EP1 (PTGER1) DMSYQP9 MT DTT DMSYQP9 MA Antagonist DMSYQP9 RN MF498 [N-{[4-(5,9-Diethoxy-6-oxo-6,8-dihydro-7H-pyrrolo[3,4-g]quinolin-7-yl)-3-methylbenzyl]sulfonyl}-2-(2-methoxyphenyl)acetamide], a selective E prostanoid receptor 4 antagonist, relieves joint inflammation and pain in rodent models of rheumatoid and osteoarthritis. J Pharmacol Exp Ther. 2008 May;325(2):425-34. DMSYQP9 RU https://pubmed.ncbi.nlm.nih.gov/18287210 DM1FEVB DI DM1FEVB DM1FEVB DN MF-8623 DM1FEVB MI TTEB0GD DM1FEVB MN Cholinesterase (BCHE) DM1FEVB MT DTT DM1FEVB MA Inhibitor DM1FEVB RN A new therapeutic target in Alzheimer's disease treatment: attention to butyrylcholinesterase. Curr Med Res Opin. 2001;17(3):159-65. DM1FEVB RU https://pubmed.ncbi.nlm.nih.gov/11900310 DM3RUT8 DI DM3RUT8 DM3RUT8 DN MG-101 DM3RUT8 MI TTU7ZMG DM3RUT8 MN Proteasome (PS) DM3RUT8 MT DTT DM3RUT8 MA Modulator DM3RUT8 RN Covalent complexes of proteasome model with peptide aldehyde inhibitors MG132 and MG101: docking and molecular dynamics study.J Mol Model.2009 Dec;15(12):1481-90. DM3RUT8 RU https://www.ncbi.nlm.nih.gov/pubmed/19440739 DM710KZ DI DM710KZ DM710KZ DN MG-1101 DM710KZ MI TT6F7GZ DM710KZ MN Parathyroid hormone (PTH) DM710KZ MT DTT DM710KZ MA Modulator DM710KZ RN Daily parathyroid hormone 1-34 replacement therapy for hypoparathyroidism induces marked changes in bone turnover and structure.J Bone Miner Res.2012 Aug;27(8):1811-20. DM710KZ RU https://www.ncbi.nlm.nih.gov/pubmed/22492501 DMHR1GX DI DMHR1GX DMHR1GX DN MG-1104 DMHR1GX MI TTFEZ5Q DMHR1GX MN Coagulation factor IX (F9) DMHR1GX MT DTT DMHR1GX MA Modulator DMHR1GX RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2364). DMHR1GX RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2364 DMG56EU DI DMG56EU DMG56EU DN MG-111 DMG56EU MI TTGKNB4 DMG56EU MN Epidermal growth factor receptor (EGFR) DMG56EU MT DTT DMG56EU MA Modulator DMG56EU RN Effects of hEGF (MG111) on gastric mucosal potential difference in rats. Scand J Gastroenterol Suppl. 1989;162:198-201. DMG56EU RU https://www.ncbi.nlm.nih.gov/pubmed/2595297 DM7V58G DI DM7V58G DM7V58G DN MG149 DM7V58G MI TTH4VJL DM7V58G MN Histone acetyltransferase KAT6B (KAT6B) DM7V58G MT DTT DM7V58G MA Inhibitor DM7V58G RN 6-alkylsalicylates are selective Tip60 inhibitors and target the acetyl-CoA binding site. Eur J Med Chem. 2012 Jan;47(1):337-44. DM7V58G RU https://pubmed.ncbi.nlm.nih.gov/22100137 DMN1F7Z DI DMN1F7Z DMN1F7Z DN MG-28 DMN1F7Z MI TT7AOUD DMN1F7Z MN Fatty acid synthase (FASN) DMN1F7Z MT DTT DMN1F7Z MA Inhibitor DMN1F7Z RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2608). DMN1F7Z RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2608 DMIMKFZ DI DMIMKFZ DMIMKFZ DN MGS0028 DMIMKFZ MI TTXJ47W DMIMKFZ MN Metabotropic glutamate receptor 2 (mGluR2) DMIMKFZ MT DTT DMIMKFZ MA Agonist DMIMKFZ RN Synthesis, SARs, and pharmacological characterization of 2-amino-3 or 6-fluorobicyclo[3.1.0]hexane-2,6-dicarboxylic acid derivatives as potent, selective, and orally active group II metabotropic glutamate receptor agonists. J Med Chem. 2000 Dec 14;43(25):4893-909. DMIMKFZ RU https://pubmed.ncbi.nlm.nih.gov/11123999 DMZ9MCR DI DMZ9MCR DMZ9MCR DN MHL cyclohexylthiosemicarbazone DMZ9MCR MI TTHM0R1 DMZ9MCR MN Steryl-sulfatase (STS) DMZ9MCR MT DTT DMZ9MCR MA Inhibitor DMZ9MCR RN Thiosemicarbazones of formyl benzoic acids as novel potent inhibitors of estrone sulfatase. J Med Chem. 2007 Jul 26;50(15):3661-6. DMZ9MCR RU https://pubmed.ncbi.nlm.nih.gov/17580843 DMCN91V DI DMCN91V DMCN91V DN MI-1148 DMCN91V MI TTH9WF6 DMCN91V MN Dibasic-processing enzyme (Furin) DMCN91V MT DTT DMCN91V MA Inhibitor DMCN91V RN Novel Furin Inhibitors with Potent Anti-infectious Activity. ChemMedChem. 2015 Jul;10(7):1218-31. DMCN91V RU https://pubmed.ncbi.nlm.nih.gov/25974265 DM196LK DI DM196LK DM196LK DN MI-219 DM196LK MI TT08GJW DM196LK MN Ubiquitin-protein ligase E3 Mdm2 (MDM2) DM196LK MT DTT DM196LK MA Inhibitor DM196LK RN MI-219-zinc combination: a new paradigm in MDM2 inhibitor-based therapy. Oncogene. 2011 Jan 6;30(1):117-26. DM196LK RU https://pubmed.ncbi.nlm.nih.gov/20818437 DMJ4D1P DI DMJ4D1P DMJ4D1P DN Micrococcin DMJ4D1P MI TTLFGBV DMJ4D1P MN Bacterial 23S ribosomal RNA (Bact 23S rRNA) DMJ4D1P MT DTT DMJ4D1P MA Binder DMJ4D1P RN The apicoplast as an antimalarial drug target. Drug Resist Updat. 2001 Jun;4(3):145-51. DMJ4D1P RU https://pubmed.ncbi.nlm.nih.gov/11768328 DMTMLRN DI DMTMLRN DMTMLRN DN Microcystin-LR DMTMLRN MI TTFLH0E DMTMLRN MN Serine/threonine PP1-alpha (PPP1CA) DMTMLRN MT DTT DMTMLRN MA Inhibitor DMTMLRN RN Serine-threonine protein phosphatase inhibitors: development of potential therapeutic strategies. J Med Chem. 2002 Mar 14;45(6):1151-75. DMTMLRN RU https://pubmed.ncbi.nlm.nih.gov/11881984 DM7Y9AD DI DM7Y9AD DM7Y9AD DN Microxine DM7Y9AD MI TTH6V3D DM7Y9AD MN Cyclin-dependent kinase 1 (CDK1) DM7Y9AD MT DTT DM7Y9AD MA Inhibitor DM7Y9AD RN Microxine, a new cdc2 kinase inhibitor from the Australian marine sponge Microxina species. J Nat Prod. 2001 Apr;64(4):525-6. DM7Y9AD RU https://pubmed.ncbi.nlm.nih.gov/11325241 DM7Y9AD DI DM7Y9AD DM7Y9AD DN Microxine DM7Y9AD MI TTVKILB DM7Y9AD MN Prostaglandin G/H synthase 2 (COX-2) DM7Y9AD MT DTT DM7Y9AD MA Inhibitor DM7Y9AD RN Inhibition of cell cycle oscillation of DNA replication by a selective inhibitor of the cdc2 kinase family, butyrolactone I, in Xenopus egg extracts. Biochem Biophys Res Commun. 1994 Jan 28;198(2):536-45. DM7Y9AD RU https://pubmed.ncbi.nlm.nih.gov/8297363 DM462BT DI DM462BT DM462BT DN Milchsaure DM462BT MI DT342ZG DM462BT MN Monocarboxylate transporter 1 (SLC16A1) DM462BT MT DTP DM462BT MA Substrate DM462BT RN Distribution of monocarboxylate transporters MCT1-MCT8 in rat tissues and human skeletal muscle. Appl Physiol Nutr Metab. 2006 Feb;31(1):31-9. DM462BT RU http://www.ncbi.nlm.nih.gov/pubmed/16604139 DM462BT DI DM462BT DM462BT DN Milchsaure DM462BT MI DTLT3UG DM462BT MN Monocarboxylate transporter 2 (SLC16A7) DM462BT MT DTP DM462BT MA Substrate DM462BT RN Characterization of the high-affinity monocarboxylate transporter MCT2 in Xenopus laevis oocytes. Biochem J. 1999 Aug 1;341 ( Pt 3):529-35. DM462BT RU http://www.ncbi.nlm.nih.gov/pubmed/10417314 DM462BT DI DM462BT DM462BT DN Milchsaure DM462BT MI DTAKRNM DM462BT MN Monocarboxylate transporter 4 (SLC16A3) DM462BT MT DTP DM462BT MA Substrate DM462BT RN The low-affinity monocarboxylate transporter MCT4 is adapted to the export of lactate in highly glycolytic cells. Biochem J. 2000 Aug 15;350 Pt 1:219-27. DM462BT RU http://www.ncbi.nlm.nih.gov/pubmed/10926847 DM6BANS DI DM6BANS DM6BANS DN Miller-9E-enolide DM6BANS MI TTSXVID DM6BANS MN Nuclear factor NF-kappa-B (NFKB) DM6BANS MT DTT DM6BANS MA Inhibitor DM6BANS RN Development of a structural model for NF-kappaB inhibition of sesquiterpene lactones using self-organizing neural networks. J Med Chem. 2006 Apr 6;49(7):2241-52. DM6BANS RU https://pubmed.ncbi.nlm.nih.gov/16570920 DMFMOX5 DI DMFMOX5 DMFMOX5 DN Miller-9Z-enolide DMFMOX5 MI TTSXVID DMFMOX5 MN Nuclear factor NF-kappa-B (NFKB) DMFMOX5 MT DTT DMFMOX5 MA Inhibitor DMFMOX5 RN Development of a structural model for NF-kappaB inhibition of sesquiterpene lactones using self-organizing neural networks. J Med Chem. 2006 Apr 6;49(7):2241-52. DMFMOX5 RU https://pubmed.ncbi.nlm.nih.gov/16570920 DM7DT20 DI DM7DT20 DM7DT20 DN Mimovax DM7DT20 MI TTE4KHA DM7DT20 MN Amyloid beta A4 protein (APP) DM7DT20 MT DTT DM7DT20 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2402). DM7DT20 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2402 DMDQK9G DI DMDQK9G DMDQK9G DN Miocamycin DMDQK9G MI DE4LYSA DMDQK9G MN Cytochrome P450 3A4 (CYP3A4) DMDQK9G MT DME DMDQK9G MA Metabolism DMDQK9G RN Inhibition of triazolam clearance by macrolide antimicrobial agents: in vitro correlates and dynamic consequences. Clin Pharmacol Ther. 1998 Sep;64(3):278-85. DMDQK9G RU https://www.ncbi.nlm.nih.gov/pubmed/?term=9757151 DM2IGD1 DI DM2IGD1 DM2IGD1 DN MIP-1231 DM2IGD1 MI TTGPQ0F DM2IGD1 MN Prolyl endopeptidase FAP (FAP) DM2IGD1 MT DTT DM2IGD1 MA Antagonist DM2IGD1 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2365). DM2IGD1 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2365 DM0J38I DI DM0J38I DM0J38I DN MIP-1375 DM0J38I MI TT9G4N0 DM0J38I MN Glutamate carboxypeptidase II (GCPII) DM0J38I MT DTT DM0J38I MA Inhibitor DM0J38I RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1606). DM0J38I RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1606 DM4P9LJ DI DM4P9LJ DM4P9LJ DN MiR-375 DM4P9LJ MI TTYMGWX DM4P9LJ MN PDK-1 messenger RNA (PDK-1 mRNA) DM4P9LJ MT DTT DM4P9LJ MA Binder DM4P9LJ RN miR-375 targets 3'-phosphoinositide-dependent protein kinase-1 and regulates glucose-induced biological responses in pancreatic beta-cells. Diabetes. 2008 Oct;57(10):2708-17. DM4P9LJ RU https://pubmed.ncbi.nlm.nih.gov/18591395 DMYB0HK DI DMYB0HK DMYB0HK DN Misonidazole DMYB0HK MI DE0QLUZ DMYB0HK MN Oxygen-insensitive NADPH nitroreductase B (nfsB) DMYB0HK MT DME DMYB0HK MA Metabolism DMYB0HK RN Metronidazole (flagyl) and misonidazole (Ro-07-0582): reduction by facultative anaerobes and cytotoxic action on hypoxic bacteria and mammalian cells in vivo. Br J Cancer Suppl. 1978 Jun;3:132-5. DMYB0HK RU https://pubmed.ncbi.nlm.nih.gov/354677 DM13TUY DI DM13TUY DM13TUY DN MIV-710 DM13TUY MI TTDZN01 DM13TUY MN Cathepsin K (CTSK) DM13TUY MT DTT DM13TUY MA Modulator DM13TUY RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2350). DM13TUY RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2350 DMMP6YH DI DMMP6YH DMMP6YH DN MJ-451 DMMP6YH MI TT1VOHK DMMP6YH MN Potassium channel unspecific (KC) DMMP6YH MT DTT DMMP6YH MA Modulator DMMP6YH RN Pharmacological characteristics of MJ-451, a new benzopyran- derived ATP-sensitive potassium channel opener, in guinea pig isolated trachea. Pharmacology. 1998 Dec;57(6):314-22. DMMP6YH RU https://www.ncbi.nlm.nih.gov/pubmed/9792972 DMRSBWT DI DMRSBWT DMRSBWT DN MJN228 DMRSBWT MI TT6A5ZL DMRSBWT MN Nucleobindin-1 (NUCB1) DMRSBWT MT DTT DMRSBWT MA Antagonist DMRSBWT RN A Global Map of Lipid-Binding Proteins and Their Ligandability in Cells. Cell. 2015 Jun 18;161(7):1668-80. DMRSBWT RU https://pubmed.ncbi.nlm.nih.gov/26091042 DMTFRLO DI DMTFRLO DMTFRLO DN MK-0343 DMTFRLO MI TTBMV1G DMTFRLO MN GABA(A) receptor alpha-2 (GABRA2) DMTFRLO MT DTT DMTFRLO MA Modulator DMTFRLO RN Pharmacodynamic and pharmacokinetic effects of MK-0343, a GABA(A) alpha2,3 subtype selective agonist, compared to lorazepam and placebo in healthy male volunteers.J Psychopharmacol.2008 Jan;22(1):24-32. DMTFRLO RU https://www.ncbi.nlm.nih.gov/pubmed/18187530 DMTFRLO DI DMTFRLO DMTFRLO DN MK-0343 DMTFRLO MI TT37EDJ DMTFRLO MN GABA(A) receptor alpha-3 (GABRA3) DMTFRLO MT DTT DMTFRLO MA Modulator DMTFRLO RN Pharmacodynamic and pharmacokinetic effects of MK-0343, a GABA(A) alpha2,3 subtype selective agonist, compared to lorazepam and placebo in healthy male volunteers.J Psychopharmacol.2008 Jan;22(1):24-32. DMTFRLO RU https://www.ncbi.nlm.nih.gov/pubmed/18187530 DMVBFJP DI DMVBFJP DMVBFJP DN MK-0668 DMVBFJP MI TTBVIQC DMVBFJP MN Integrin beta-1 (ITGB1) DMVBFJP MT DTT DMVBFJP MA Inhibitor DMVBFJP RN Discovery of N-{N-[(3-cyanobenzene) sulfonyl]-4(R)-(3,3-difluoropiperidin-1-yl)-(l)-prolyl}-4-[(3',5'-dichloro-isonicotinoyl) amino]-(l)-phenylalan... Bioorg Med Chem Lett. 2009 Oct 1;19(19):5803-6. DMVBFJP RU https://pubmed.ncbi.nlm.nih.gov/19713111 DMVBFJP DI DMVBFJP DMVBFJP DN MK-0668 DMVBFJP MI TTJMF9P DMVBFJP MN ITGA4 messenger RNA (ITGA4 mRNA) DMVBFJP MT DTT DMVBFJP MA Inhibitor DMVBFJP RN Discovery of N-{N-[(3-cyanobenzene) sulfonyl]-4(R)-(3,3-difluoropiperidin-1-yl)-(l)-prolyl}-4-[(3',5'-dichloro-isonicotinoyl) amino]-(l)-phenylalan... Bioorg Med Chem Lett. 2009 Oct 1;19(19):5803-6. DMVBFJP RU https://pubmed.ncbi.nlm.nih.gov/19713111 DMI7859 DI DMI7859 DMI7859 DN MK-10 DMI7859 MI TTEOSZT DMI7859 MN Melanocortin receptor (MCR) DMI7859 MT DTT DMI7859 MA Inhibitor DMI7859 RN Novel cyclic templates of alpha-MSH give highly selective and potent antagonists/agonists for human melanocortin-3/4 receptors. J Med Chem. 2002 Jun 6;45(12):2644-50. DMI7859 RU https://pubmed.ncbi.nlm.nih.gov/12036373 DMI7859 DI DMI7859 DMI7859 DN MK-10 DMI7859 MI TTNI91K DMI7859 MN Melanocortin receptor 3 (MC3R) DMI7859 MT DTT DMI7859 MA Inhibitor DMI7859 RN Novel cyclic templates of alpha-MSH give highly selective and potent antagonists/agonists for human melanocortin-3/4 receptors. J Med Chem. 2002 Jun 6;45(12):2644-50. DMI7859 RU https://pubmed.ncbi.nlm.nih.gov/12036373 DMI7859 DI DMI7859 DMI7859 DN MK-10 DMI7859 MI TTD0CIQ DMI7859 MN Melanocortin receptor 4 (MC4R) DMI7859 MT DTT DMI7859 MA Inhibitor DMI7859 RN Novel cyclic templates of alpha-MSH give highly selective and potent antagonists/agonists for human melanocortin-3/4 receptors. J Med Chem. 2002 Jun 6;45(12):2644-50. DMI7859 RU https://pubmed.ncbi.nlm.nih.gov/12036373 DM4FG32 DI DM4FG32 DM4FG32 DN MK-11 DM4FG32 MI TTEOSZT DM4FG32 MN Melanocortin receptor (MCR) DM4FG32 MT DTT DM4FG32 MA Inhibitor DM4FG32 RN Novel cyclic templates of alpha-MSH give highly selective and potent antagonists/agonists for human melanocortin-3/4 receptors. J Med Chem. 2002 Jun 6;45(12):2644-50. DM4FG32 RU https://pubmed.ncbi.nlm.nih.gov/12036373 DM4FG32 DI DM4FG32 DM4FG32 DN MK-11 DM4FG32 MI TTNI91K DM4FG32 MN Melanocortin receptor 3 (MC3R) DM4FG32 MT DTT DM4FG32 MA Inhibitor DM4FG32 RN Novel cyclic templates of alpha-MSH give highly selective and potent antagonists/agonists for human melanocortin-3/4 receptors. J Med Chem. 2002 Jun 6;45(12):2644-50. DM4FG32 RU https://pubmed.ncbi.nlm.nih.gov/12036373 DM4FG32 DI DM4FG32 DM4FG32 DN MK-11 DM4FG32 MI TTD0CIQ DM4FG32 MN Melanocortin receptor 4 (MC4R) DM4FG32 MT DTT DM4FG32 MA Inhibitor DM4FG32 RN Novel cyclic templates of alpha-MSH give highly selective and potent antagonists/agonists for human melanocortin-3/4 receptors. J Med Chem. 2002 Jun 6;45(12):2644-50. DM4FG32 RU https://pubmed.ncbi.nlm.nih.gov/12036373 DM3NDWK DI DM3NDWK DM3NDWK DN MK-1925 DM3NDWK MI TTQW87Y DM3NDWK MN Opioid receptor kappa (OPRK1) DM3NDWK MT DTT DM3NDWK MA Inhibitor DM3NDWK RN Identification of MK-1925: a selective, orally active and brain-penetrable opioid receptor-like 1 (ORL1) antagonist. Bioorg Med Chem Lett. 2009 Aug 15;19(16):4729-32. DM3NDWK RU https://pubmed.ncbi.nlm.nih.gov/19564110 DM3NDWK DI DM3NDWK DM3NDWK DN MK-1925 DM3NDWK MI TTQ6VDM DM3NDWK MN Voltage-gated potassium channel Kv11.1 (KCNH2) DM3NDWK MT DTT DM3NDWK MA Inhibitor DM3NDWK RN Identification of MK-1925: a selective, orally active and brain-penetrable opioid receptor-like 1 (ORL1) antagonist. Bioorg Med Chem Lett. 2009 Aug 15;19(16):4729-32. DM3NDWK RU https://pubmed.ncbi.nlm.nih.gov/19564110 DMYO8T6 DI DMYO8T6 DMYO8T6 DN MK-212 DMYO8T6 MI TTWJBZ5 DMYO8T6 MN 5-HT 2C receptor (HTR2C) DMYO8T6 MT DTT DMYO8T6 MA Modulator DMYO8T6 RN [Agonists of 5HT2C-receptors SCH 23390 and MK 212 incresase the force of rat aorta contraction in the presence of vasopressin and angiotensin II].Patol Fiziol Eksp Ter.2014 Oct-Dec;(4):17-29. DMYO8T6 RU https://www.ncbi.nlm.nih.gov/pubmed/25980223 DMP4Q0J DI DMP4Q0J DMP4Q0J DN MK-2894 DMP4Q0J MI TT79WV3 DMP4Q0J MN Prostaglandin E2 receptor EP4 (PTGER4) DMP4Q0J MT DTT DMP4Q0J MA Antagonist DMP4Q0J RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 343). DMP4Q0J RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=343 DM5EQ7F DI DM5EQ7F DM5EQ7F DN MK-3901 DM5EQ7F MI TT2THBD DM5EQ7F MN P2X purinoceptor 3 (P2RX3) DM5EQ7F MT DTT DM5EQ7F MA Antagonist DM5EQ7F RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 480). DM5EQ7F RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=480 DMS7C6R DI DMS7C6R DMS7C6R DN MK-5046 DMS7C6R MI TTHYDUM DMS7C6R MN Bombesin receptor (BS) DMS7C6R MT DTT DMS7C6R MA Agonist DMS7C6R RN Antiobesity effect of MK-5046, a novel bombesin receptor subtype-3 agonist. J Pharmacol Exp Ther. 2011 Feb;336(2):356-64. DMS7C6R RU https://pubmed.ncbi.nlm.nih.gov/21036912 DMS7C6R DI DMS7C6R DMS7C6R DN MK-5046 DMS7C6R MI TTC1MVT DMS7C6R MN Gastrin-releasing peptide receptor (GRPR) DMS7C6R MT DTT DMS7C6R MA Agonist DMS7C6R RN Comparative pharmacology of bombesin receptor subtype-3, nonpeptide agonist MK-5046, a universal peptide agonist, and peptide antagonist Bantag-1 for human bombesin receptors. J Pharmacol Exp Ther. 2013 Oct;347(1):100-16. DMS7C6R RU https://pubmed.ncbi.nlm.nih.gov/23892571 DMU8VRB DI DMU8VRB DMU8VRB DN MK-5435 DMU8VRB MI TTVBPDM DMU8VRB MN Metabotropic glutamate receptor 1 (mGluR1) DMU8VRB MT DTT DMU8VRB MA Modulator (allosteric modulator) DMU8VRB RN Synthesis, characterization, and monkey PET studies of [ ]MK-1312, a PET tracer for quantification of mGluR1 receptor occupancy by MK-5435. Synapse. 2011 Feb;65(2):125-35. DMU8VRB RU https://pubmed.ncbi.nlm.nih.gov/20524178 DMLWMZ4 DI DMLWMZ4 DMLWMZ4 DN MK-5596 DMLWMZ4 MI TT6OEDT DMLWMZ4 MN Cannabinoid receptor 1 (CB1) DMLWMZ4 MT DTT DMLWMZ4 MA Agonist DMLWMZ4 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 56). DMLWMZ4 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=56 DMR9C4Q DI DMR9C4Q DMR9C4Q DN MK-6892 DMR9C4Q MI TTWNV8U DMR9C4Q MN Nicotinic acid receptor (HCAR2) DMR9C4Q MT DTT DMR9C4Q MA Agonist DMR9C4Q RN Discovery of SCH 900271, a Potent Nicotinic Acid Receptor Agonist for the Treatment of Dyslipidemia. ACS Med Chem Lett. 2011 Nov 24;3(1):63-8. DMR9C4Q RU https://pubmed.ncbi.nlm.nih.gov/24900372 DM4YQV0 DI DM4YQV0 DM4YQV0 DN MK-771 DM4YQV0 MI TT4J8MF DM4YQV0 MN Thyrotropin-releasing hormone receptor (TRHR) DM4YQV0 MT DTT DM4YQV0 MA Modulator DM4YQV0 RN TRH analog MK-771 reverses neurochemical and learning deficits in medial septal-lesioned rats. Peptides. 1989 Jan-Feb;10(1):121-4. DM4YQV0 RU https://www.ncbi.nlm.nih.gov/pubmed/2501767 DM3EP59 DI DM3EP59 DM3EP59 DN MK-7725 DM3EP59 MI TTKYEPM DM3EP59 MN Bombesin-like receptor 3 (BRS3) DM3EP59 MT DTT DM3EP59 MA Agonist DM3EP59 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 8502). DM3EP59 RU http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=8502 DMKEG2B DI DMKEG2B DMKEG2B DN MK-9 DMKEG2B MI TTNI91K DMKEG2B MN Melanocortin receptor 3 (MC3R) DMKEG2B MT DTT DMKEG2B MA Inhibitor DMKEG2B RN Structure-activity relationships of cyclic lactam analogues of alpha-melanocyte-stimulating hormone (alpha-MSH) targeting the human melanocortin-3 ... J Med Chem. 2008 Jan 24;51(2):187-95. DMKEG2B RU https://pubmed.ncbi.nlm.nih.gov/18088090 DM4ZNOU DI DM4ZNOU DM4ZNOU DN ML 10375 DM4ZNOU MI TT07C3Y DM4ZNOU MN 5-HT 4 receptor (HTR4) DM4ZNOU MT DTT DM4ZNOU MA Antagonist DM4ZNOU RN Exploration of the ligand binding site of the human 5-HT(4) receptor by site-directed mutagenesis and molecular modeling. Br J Pharmacol. 2000 Jun;130(3):527-38. DM4ZNOU RU https://pubmed.ncbi.nlm.nih.gov/10821780 DMM5P8Q DI DMM5P8Q DMM5P8Q DN ML-10302 DMM5P8Q MI TT07C3Y DMM5P8Q MN 5-HT 4 receptor (HTR4) DMM5P8Q MT DTT DMM5P8Q MA Modulator DMM5P8Q RN Intestinal motor stimulation by the 5-HT4 receptor agonist ML10302: differential involvement of tachykininergic pathways in the canine small bowel ... Neurogastroenterol Motil. 2001 Dec;13(6):543-53. DMM5P8Q RU https://www.ncbi.nlm.nih.gov/pubmed/11903915 DMPB7EL DI DMPB7EL DMPB7EL DN ML169 DMPB7EL MI TTOXS3C DMPB7EL MN Muscarinic acetylcholine receptor (CHRM) DMPB7EL MT DTT DMPB7EL MA Modulator (allosteric modulator) DMPB7EL RN Targeting selective activation of M(1) for the treatment of Alzheimer's disease: further chemical optimization and pharmacological characterization of the M(1) positive allosteric modulator ML169. ACS Chem Neurosci. 2012 Nov 21;3(11):884-95. DMPB7EL RU https://pubmed.ncbi.nlm.nih.gov/23173069 DMHJCN6 DI DMHJCN6 DMHJCN6 DN ML-18 DMHJCN6 MI TTHYDUM DMHJCN6 MN Bombesin receptor (BS) DMHJCN6 MT DTT DMHJCN6 MA Antagonist DMHJCN6 RN ML-18 is a non-peptide bombesin receptor subtype-3 antagonist which inhibits lung cancer growth. Peptides. 2015 Feb;64:55-61. DMHJCN6 RU https://pubmed.ncbi.nlm.nih.gov/25554218 DM15YL0 DI DM15YL0 DM15YL0 DN ML204 DM15YL0 MI TTX0H5W DM15YL0 MN Short transient receptor potential channel 4 (TRPC4) DM15YL0 MT DTT DM15YL0 MA Blocker (channel blocker) DM15YL0 RN Identification of ML204, a novel potent antagonist that selectively modulates native TRPC4/C5 ion channels. J Biol Chem. 2011 Sep 23;286(38):33436-46. DM15YL0 RU https://pubmed.ncbi.nlm.nih.gov/21795696 DM15YL0 DI DM15YL0 DM15YL0 DN ML204 DM15YL0 MI TT32NQ1 DM15YL0 MN Short transient receptor potential channel 5 (TRPC5) DM15YL0 MT DTT DM15YL0 MA Blocker (channel blocker) DM15YL0 RN Identification of ML204, a novel potent antagonist that selectively modulates native TRPC4/C5 ion channels. J Biol Chem. 2011 Sep 23;286(38):33436-46. DM15YL0 RU https://pubmed.ncbi.nlm.nih.gov/21795696 DMFAUGP DI DMFAUGP DMFAUGP DN ML213 DMFAUGP MI TT8HGRW DMFAUGP MN Voltage-gated potassium channel Kv7.4 (KCNQ4) DMFAUGP MT DTT DMFAUGP MA Activator DMFAUGP RN Discovery, Synthesis, and Structure Activity Relationship of a Series of N-Aryl- bicyclo[2.2.1]heptane-2-carboxamides: Characterization of ML213 as a Novel KCNQ2 and KCNQ4 Potassium Channel Opener. ACS Chem Neurosci. 2011 Oct 19;2(10):572-577. DMFAUGP RU https://pubmed.ncbi.nlm.nih.gov/22125664 DM3D21X DI DM3D21X DM3D21X DN ML218 DM3D21X MI TT729IR DM3D21X MN Voltage-gated calcium channel alpha Cav3.1 (CACNA1G) DM3D21X MT DTT DM3D21X MA Blocker (channel blocker) DM3D21X RN The Discovery and Characterization of ML218: A Novel, Centrally Active T-Type Calcium Channel Inhibitor with Robust Effects in STN Neurons and in a Rodent Model of Parkinson's Disease. ACS Chem Neurosci. 2011 Dec 21;2(12):730-742. DM3D21X RU https://pubmed.ncbi.nlm.nih.gov/22368764 DM3D21X DI DM3D21X DM3D21X DN ML218 DM3D21X MI TTZPWGN DM3D21X MN Voltage-gated calcium channel alpha Cav3.2 (CACNA1H) DM3D21X MT DTT DM3D21X MA Blocker (channel blocker) DM3D21X RN The Discovery and Characterization of ML218: A Novel, Centrally Active T-Type Calcium Channel Inhibitor with Robust Effects in STN Neurons and in a Rodent Model of Parkinson's Disease. ACS Chem Neurosci. 2011 Dec 21;2(12):730-742. DM3D21X RU https://pubmed.ncbi.nlm.nih.gov/22368764 DM3D21X DI DM3D21X DM3D21X DN ML218 DM3D21X MI TTQZFTH DM3D21X MN Voltage-gated calcium channel alpha Cav3.3 (CACNA1I) DM3D21X MT DTT DM3D21X MA Blocker (channel blocker) DM3D21X RN The Discovery and Characterization of ML218: A Novel, Centrally Active T-Type Calcium Channel Inhibitor with Robust Effects in STN Neurons and in a Rodent Model of Parkinson's Disease. ACS Chem Neurosci. 2011 Dec 21;2(12):730-742. DM3D21X RU https://pubmed.ncbi.nlm.nih.gov/22368764 DM3OEP4 DI DM3OEP4 DM3OEP4 DN ML221 DM3OEP4 MI TTJ8E43 DM3OEP4 MN Apelin receptor (APLNR) DM3OEP4 MT DTT DM3OEP4 MA Antagonist DM3OEP4 RN Discovery of 4-oxo-6-((pyrimidin-2-ylthio)methyl)-4H-pyran-3-yl 4-nitrobenzoate (ML221) as a functional antagonist of the apelin (APJ) receptor. Bioorg Med Chem Lett. 2012 Nov 1;22(21):6656-60. DM3OEP4 RU https://pubmed.ncbi.nlm.nih.gov/23010269 DM8CIE4 DI DM8CIE4 DM8CIE4 DN ML233 DM8CIE4 MI TTJ8E43 DM8CIE4 MN Apelin receptor (APLNR) DM8CIE4 MT DTT DM8CIE4 MA Agonist DM8CIE4 RN Functional Agonists of the Apelin (APJ) Receptor. Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010. DM8CIE4 RU https://pubmed.ncbi.nlm.nih.gov/22834038 DMK6YC1 DI DMK6YC1 DMK6YC1 DN ML-253764 DMK6YC1 MI TTD0CIQ DMK6YC1 MN Melanocortin receptor 4 (MC4R) DMK6YC1 MT DTT DMK6YC1 MA Inhibitor DMK6YC1 RN Mapping the binding site of melanocortin 4 receptor agonists: a hydrophobic pocket formed by I3.28(125), I3.32(129), and I7.42(291) is critical for... J Med Chem. 2006 Feb 9;49(3):911-22. DMK6YC1 RU https://pubmed.ncbi.nlm.nih.gov/16451057 DMQ98RS DI DMQ98RS DMQ98RS DN ML277 DMQ98RS MI TT846HF DMQ98RS MN Voltage-gated potassium channel Kv7.1 (KCNQ1) DMQ98RS MT DTT DMQ98RS MA Activator DMQ98RS RN Identification of (R)-N-(4-(4-methoxyphenyl)thiazol-2-yl)-1-tosylpiperidine-2-carboxamide, ML277, as a novel, potent and selective K(v)7.1 (KCNQ1) potassium channel activator. Bioorg Med Chem Lett. 2012 Sep 15;22(18):5936-41. DMQ98RS RU https://pubmed.ncbi.nlm.nih.gov/22910039 DMPOX4Q DI DMPOX4Q DMPOX4Q DN ML290 DMPOX4Q MI TTMAHD1 DMPOX4Q MN Relaxin receptor 1 (RXFP1) DMPOX4Q MT DTT DMPOX4Q MA Modulator (allosteric modulator) DMPOX4Q RN Discovery, optimization, and biological activity of the first potent and selective small-molecule agonist series of human relaxin receptor 1 (RXFP1). Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010. DMPOX4Q RU https://pubmed.ncbi.nlm.nih.gov/23905199 DMY40UG DI DMY40UG DMY40UG DN ML297 DMY40UG MI TTGM19J DMY40UG MN Inward rectifier potassium channel Kir3.1 (KCNJ3) DMY40UG MT DTT DMY40UG MA Activator DMY40UG RN ML297 (VU0456810), the first potent and selective activator of the GIRK potassium channel, displays antiepileptic properties in mice. ACS Chem Neurosci. 2013 Sep 18;4(9):1278-86. DMY40UG RU https://pubmed.ncbi.nlm.nih.gov/23730969 DMNOREK DI DMNOREK DMNOREK DN ML315 DMNOREK MI TTE6YDG DMNOREK MN CDC-like kinase 1 (CLK1) DMNOREK MT DTT DMNOREK MA Inhibitor DMNOREK RN Small-molecule pyrimidine inhibitors of the cdc2-like (Clk) and dual specificity tyrosine phosphorylation-regulated (Dyrk) kinases: development of chemical probe ML315. Bioorg Med Chem Lett. 2013 Jun15;23(12):3654-61. DMNOREK RU https://pubmed.ncbi.nlm.nih.gov/23642479 DMNOREK DI DMNOREK DMNOREK DN ML315 DMNOREK MI TT85TPS DMNOREK MN CDC-like kinase 2 (CLK2) DMNOREK MT DTT DMNOREK MA Inhibitor DMNOREK RN Small-molecule pyrimidine inhibitors of the cdc2-like (Clk) and dual specificity tyrosine phosphorylation-regulated (Dyrk) kinases: development of chemical probe ML315. Bioorg Med Chem Lett. 2013 Jun15;23(12):3654-61. DMNOREK RU https://pubmed.ncbi.nlm.nih.gov/23642479 DMNOREK DI DMNOREK DMNOREK DN ML315 DMNOREK MI TT1RFQP DMNOREK MN CDC-like kinase 4 (CLK4) DMNOREK MT DTT DMNOREK MA Inhibitor DMNOREK RN Small-molecule pyrimidine inhibitors of the cdc2-like (Clk) and dual specificity tyrosine phosphorylation-regulated (Dyrk) kinases: development of chemical probe ML315. Bioorg Med Chem Lett. 2013 Jun15;23(12):3654-61. DMNOREK RU https://pubmed.ncbi.nlm.nih.gov/23642479 DMNOREK DI DMNOREK DMNOREK DN ML315 DMNOREK MI TTSBVFO DMNOREK MN Dual-specificity tyrosine-phosphorylation regulated kinase 1A (DYRK1A) DMNOREK MT DTT DMNOREK MA Inhibitor DMNOREK RN Small-molecule pyrimidine inhibitors of the cdc2-like (Clk) and dual specificity tyrosine phosphorylation-regulated (Dyrk) kinases: development of chemical probe ML315. Bioorg Med Chem Lett. 2013 Jun15;23(12):3654-61. DMNOREK RU https://pubmed.ncbi.nlm.nih.gov/23642479 DM3S5UC DI DM3S5UC DM3S5UC DN ML-3163 DM3S5UC MI TTXV4FI DM3S5UC MN Albendazole monooxygenase (CYP3A4) DM3S5UC MT DTT DM3S5UC MA Inhibitor DM3S5UC RN Novel substituted pyridinyl imidazoles as potent anticytokine agents with low activity against hepatic cytochrome P450 enzymes. J Med Chem. 2003 Jul 17;46(15):3230-44. DM3S5UC RU https://pubmed.ncbi.nlm.nih.gov/12852754 DM3S5UC DI DM3S5UC DM3S5UC DN ML-3163 DM3S5UC MI TTVG215 DM3S5UC MN Debrisoquine 4-hydroxylase (CYP2D6) DM3S5UC MT DTT DM3S5UC MA Inhibitor DM3S5UC RN Novel substituted pyridinyl imidazoles as potent anticytokine agents with low activity against hepatic cytochrome P450 enzymes. J Med Chem. 2003 Jul 17;46(15):3230-44. DM3S5UC RU https://pubmed.ncbi.nlm.nih.gov/12852754 DM3S5UC DI DM3S5UC DM3S5UC DN ML-3163 DM3S5UC MI TTYT93M DM3S5UC MN MAP kinase p38 (MAPK12) DM3S5UC MT DTT DM3S5UC MA Inhibitor DM3S5UC RN From imidazoles to pyrimidines: new inhibitors of cytokine release. J Med Chem. 2002 Jun 20;45(13):2733-40. DM3S5UC RU https://pubmed.ncbi.nlm.nih.gov/12061876 DM3S5UC DI DM3S5UC DM3S5UC DN ML-3163 DM3S5UC MI TTQBR95 DM3S5UC MN Stress-activated protein kinase 2a (p38 alpha) DM3S5UC MT DTT DM3S5UC MA Inhibitor DM3S5UC RN From imidazoles to pyrimidines: new inhibitors of cytokine release. J Med Chem. 2002 Jun 20;45(13):2733-40. DM3S5UC RU https://pubmed.ncbi.nlm.nih.gov/12061876 DM3S5UC DI DM3S5UC DM3S5UC DN ML-3163 DM3S5UC MI TT73U6C DM3S5UC MN Stress-activated protein kinase 2b (p38 beta) DM3S5UC MT DTT DM3S5UC MA Inhibitor DM3S5UC RN From imidazoles to pyrimidines: new inhibitors of cytokine release. J Med Chem. 2002 Jun 20;45(13):2733-40. DM3S5UC RU https://pubmed.ncbi.nlm.nih.gov/12061876 DMVELYW DI DMVELYW DMVELYW DN ML321 DMVELYW MI TTEX248 DMVELYW MN Dopamine D2 receptor (D2R) DMVELYW MT DTT DMVELYW MA Antagonist DMVELYW RN Discovery, optimization, and characterization of a novel series of dopamine D2 versus D3 receptor selective antagonists. Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010. DMVELYW RU https://pubmed.ncbi.nlm.nih.gov/24260782 DMXJY6W DI DMXJY6W DMXJY6W DN ML-3375 DMXJY6W MI TTXV4FI DMXJY6W MN Albendazole monooxygenase (CYP3A4) DMXJY6W MT DTT DMXJY6W MA Inhibitor DMXJY6W RN Novel substituted pyridinyl imidazoles as potent anticytokine agents with low activity against hepatic cytochrome P450 enzymes. J Med Chem. 2003 Jul 17;46(15):3230-44. DMXJY6W RU https://pubmed.ncbi.nlm.nih.gov/12852754 DMXJY6W DI DMXJY6W DMXJY6W DN ML-3375 DMXJY6W MI TTYT93M DMXJY6W MN MAP kinase p38 (MAPK12) DMXJY6W MT DTT DMXJY6W MA Inhibitor DMXJY6W RN Novel substituted pyridinyl imidazoles as potent anticytokine agents with low activity against hepatic cytochrome P450 enzymes. J Med Chem. 2003 Jul 17;46(15):3230-44. DMXJY6W RU https://pubmed.ncbi.nlm.nih.gov/12852754 DMXJY6W DI DMXJY6W DMXJY6W DN ML-3375 DMXJY6W MI TTQBR95 DMXJY6W MN Stress-activated protein kinase 2a (p38 alpha) DMXJY6W MT DTT DMXJY6W MA Inhibitor DMXJY6W RN Novel substituted pyridinyl imidazoles as potent anticytokine agents with low activity against hepatic cytochrome P450 enzymes. J Med Chem. 2003 Jul 17;46(15):3230-44. DMXJY6W RU https://pubmed.ncbi.nlm.nih.gov/12852754 DMXJY6W DI DMXJY6W DMXJY6W DN ML-3375 DMXJY6W MI TT73U6C DMXJY6W MN Stress-activated protein kinase 2b (p38 beta) DMXJY6W MT DTT DMXJY6W MA Inhibitor DMXJY6W RN Novel substituted pyridinyl imidazoles as potent anticytokine agents with low activity against hepatic cytochrome P450 enzymes. J Med Chem. 2003 Jul 17;46(15):3230-44. DMXJY6W RU https://pubmed.ncbi.nlm.nih.gov/12852754 DMTQWI8 DI DMTQWI8 DMTQWI8 DN ML-3403 DMTQWI8 MI TTXV4FI DMTQWI8 MN Albendazole monooxygenase (CYP3A4) DMTQWI8 MT DTT DMTQWI8 MA Inhibitor DMTQWI8 RN Novel substituted pyridinyl imidazoles as potent anticytokine agents with low activity against hepatic cytochrome P450 enzymes. J Med Chem. 2003 Jul 17;46(15):3230-44. DMTQWI8 RU https://pubmed.ncbi.nlm.nih.gov/12852754 DMTQWI8 DI DMTQWI8 DMTQWI8 DN ML-3403 DMTQWI8 MI TTYT93M DMTQWI8 MN MAP kinase p38 (MAPK12) DMTQWI8 MT DTT DMTQWI8 MA Inhibitor DMTQWI8 RN Novel substituted pyridinyl imidazoles as potent anticytokine agents with low activity against hepatic cytochrome P450 enzymes. J Med Chem. 2003 Jul 17;46(15):3230-44. DMTQWI8 RU https://pubmed.ncbi.nlm.nih.gov/12852754 DMTQWI8 DI DMTQWI8 DMTQWI8 DN ML-3403 DMTQWI8 MI TTQBR95 DMTQWI8 MN Stress-activated protein kinase 2a (p38 alpha) DMTQWI8 MT DTT DMTQWI8 MA Inhibitor DMTQWI8 RN Novel substituted pyridinyl imidazoles as potent anticytokine agents with low activity against hepatic cytochrome P450 enzymes. J Med Chem. 2003 Jul 17;46(15):3230-44. DMTQWI8 RU https://pubmed.ncbi.nlm.nih.gov/12852754 DMTQWI8 DI DMTQWI8 DMTQWI8 DN ML-3403 DMTQWI8 MI TT73U6C DMTQWI8 MN Stress-activated protein kinase 2b (p38 beta) DMTQWI8 MT DTT DMTQWI8 MA Inhibitor DMTQWI8 RN Novel substituted pyridinyl imidazoles as potent anticytokine agents with low activity against hepatic cytochrome P450 enzymes. J Med Chem. 2003 Jul 17;46(15):3230-44. DMTQWI8 RU https://pubmed.ncbi.nlm.nih.gov/12852754 DMR8N36 DI DMR8N36 DMR8N36 DN ML347 DMR8N36 MI TTJNBQA DMR8N36 MN Activin receptor-like kinase 2 (ALK-2) DMR8N36 MT DTT DMR8N36 MA Inhibitor DMR8N36 RN Synthesis and structure-activity relationships of a novel and selective bone morphogenetic protein receptor (BMP) inhibitor derived from the pyrazolo[1.5-a]pyrimidine scaffold of dorsomorphin: the discovery of ML347 as an ALK2 versus ALK3 selective MLPCN probe. Bioorg Med Chem Lett. 2013 Jun 1;23(11):3248-52. DMR8N36 RU https://pubmed.ncbi.nlm.nih.gov/23639540 DMR8N36 DI DMR8N36 DMR8N36 DN ML347 DMR8N36 MI TTGYPTC DMR8N36 MN Activin receptor-like kinase-1 (ACVRL1) DMR8N36 MT DTT DMR8N36 MA Inhibitor DMR8N36 RN Synthesis and structure-activity relationships of a novel and selective bone morphogenetic protein receptor (BMP) inhibitor derived from the pyrazolo[1.5-a]pyrimidine scaffold of dorsomorphin: the discovery of ML347 as an ALK2 versus ALK3 selective MLPCN probe. Bioorg Med Chem Lett. 2013 Jun 1;23(11):3248-52. DMR8N36 RU https://pubmed.ncbi.nlm.nih.gov/23639540 DMR8N36 DI DMR8N36 DMR8N36 DN ML347 DMR8N36 MI TTGKF90 DMR8N36 MN Bone morphogenetic protein receptor (BMPR2) DMR8N36 MT DTT DMR8N36 MA Inhibitor DMR8N36 RN Synthesis and structure-activity relationships of a novel and selective bone morphogenetic protein receptor (BMP) inhibitor derived from the pyrazolo[1.5-a]pyrimidine scaffold of dorsomorphin: the discovery of ML347 as an ALK2 versus ALK3 selective MLPCN probe. Bioorg Med Chem Lett. 2013 Jun 1;23(11):3248-52. DMR8N36 RU https://pubmed.ncbi.nlm.nih.gov/23639540 DMXJASC DI DMXJASC DMXJASC DN ML375 DMXJASC MI TTOXS3C DMXJASC MN Muscarinic acetylcholine receptor (CHRM) DMXJASC MT DTT DMXJASC MA Modulator (allosteric modulator) DMXJASC RN Discovery of the first M5-selective and CNS penetrant negative allosteric modulator (NAM) of a muscarinic acetylcholine receptor: (S)-9b-(4-chlorophenyl)-1-(3,4-difluorobenzoyl)-2,3-dihydro-1H-imidazo[2,1-a]isoindol-5(9bH)-one (ML375). J Med Chem. 2013 Nov 27;56(22):9351-5. DMXJASC RU https://pubmed.ncbi.nlm.nih.gov/24164599 DMQROC3 DI DMQROC3 DMQROC3 DN ML380 DMQROC3 MI TTOXS3C DMQROC3 MN Muscarinic acetylcholine receptor (CHRM) DMQROC3 MT DTT DMQROC3 MA Modulator (allosteric modulator) DMQROC3 RN Development of a highly potent, novel M5 positive allosteric modulator (PAM) demonstrating CNS exposure: 1-((1H-indazol-5-yl)sulfoneyl)-N-ethyl-N-(2-(trifluoromethyl)benzyl)piperidine-4-carboxamide (ML380). J Med Chem. 2014 Sep 25;57(18):7804-10. DMQROC3 RU https://pubmed.ncbi.nlm.nih.gov/25147929 DMKCIP0 DI DMKCIP0 DMKCIP0 DN ML381 DMKCIP0 MI TTOXS3C DMKCIP0 MN Muscarinic acetylcholine receptor (CHRM) DMKCIP0 MT DTT DMKCIP0 MA Antagonist DMKCIP0 RN Discovery, synthesis and characterization of a highly muscarinic acetylcholine receptor (mAChR)-selective M5-orthosteric antagonist, VU0488130 (ML381): a novel molecular probe. ChemMedChem. 2014 Aug;9(8):1677-82. DMKCIP0 RU https://pubmed.ncbi.nlm.nih.gov/24692176 DMKCIP0 DI DMKCIP0 DMKCIP0 DN ML381 DMKCIP0 MI TTQ13Z5 DMKCIP0 MN Muscarinic acetylcholine receptor M3 (CHRM3) DMKCIP0 MT DTT DMKCIP0 MA Antagonist DMKCIP0 RN Discovery, synthesis and characterization of a highly muscarinic acetylcholine receptor (mAChR)-selective M5-orthosteric antagonist, VU0488130 (ML381): a novel molecular probe. ChemMedChem. 2014 Aug;9(8):1677-82. DMKCIP0 RU https://pubmed.ncbi.nlm.nih.gov/24692176 DMA0E2Q DI DMA0E2Q DMA0E2Q DN ML398 DMA0E2Q MI TTE0A2F DMA0E2Q MN Dopamine D4 receptor (D4R) DMA0E2Q MT DTT DMA0E2Q MA Antagonist DMA0E2Q RN Discovery and Characterization of ML398, a Potent and Selective Antagonist of the D4 Receptor with in Vivo Activity. ACS Med Chem Lett. 2014 Jul 9;5(9):1060-4. DMA0E2Q RU https://pubmed.ncbi.nlm.nih.gov/25221667 DMP13VE DI DMP13VE DMP13VE DN ML9 DMP13VE MI TTRBT3W DMP13VE MN Short transient receptor potential channel 6 (TRPC6) DMP13VE MT DTT DMP13VE MA Blocker (channel blocker) DMP13VE RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 491). DMP13VE RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=491 DMTU0IG DI DMTU0IG DMTU0IG DN MLN-0905 DMTU0IG MI TTIYVQP DMTU0IG MN Polo-like kinase 1 (PLK1) DMTU0IG MT DTT DMTU0IG MA Inhibitor DMTU0IG RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2168). DMTU0IG RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2168 DMYKNSP DI DMYKNSP DMYKNSP DN MLN-120B DMYKNSP MI TTRPDBG DMYKNSP MN Inhibitor of nuclear factor kappa-B kinase (IKK) DMYKNSP MT DTT DMYKNSP MA Inhibitor DMYKNSP RN A selective small molecule IkappaB Kinase beta inhibitor blocks nuclear factor kappaB-mediated inflammatory responses in human fibroblast-like syno... J Pharmacol Exp Ther. 2006 Jun;317(3):989-1001. DMYKNSP RU https://pubmed.ncbi.nlm.nih.gov/16525037 DMPTBJZ DI DMPTBJZ DMPTBJZ DN MLS1547 DMPTBJZ MI TTEX248 DMPTBJZ MN Dopamine D2 receptor (D2R) DMPTBJZ MT DTT DMPTBJZ MA Agonist DMPTBJZ RN Discovery and characterization of a G protein-biased agonist that inhibits beta-arrestin recruitment to the D2 dopamine receptor. Mol Pharmacol. 2014 Jul;86(1):96-105. DMPTBJZ RU https://pubmed.ncbi.nlm.nih.gov/24755247 DMT1NP8 DI DMT1NP8 DMT1NP8 DN MM 11253 DMT1NP8 MI TT1Q3IE DMT1NP8 MN Retinoic acid receptor gamma (RARG) DMT1NP8 MT DTT DMT1NP8 MA Antagonist DMT1NP8 RN Modulation of retinoic acid receptor function alters the growth inhibitory response of oral SCC cells to retinoids. Oncogene. 2000 Mar 9;19(11):1457-65. DMT1NP8 RU https://pubmed.ncbi.nlm.nih.gov/10723137 DMB74MS DI DMB74MS DMB74MS DN MM3A6S DMB74MS MI TTKWM86 DMB74MS MN Opioid receptor mu (MOP) DMB74MS MT DTT DMB74MS MA Inhibitor DMB74MS RN Opiate receptor binding properties of morphine-, dihydromorphine-, and codeine 6-O-sulfate ester congeners. Bioorg Med Chem Lett. 2006 Aug 15;16(16):4291-5. DMB74MS RU https://pubmed.ncbi.nlm.nih.gov/16777416 DM9PGQI DI DM9PGQI DM9PGQI DN MM3B6S DM9PGQI MI TTKWM86 DM9PGQI MN Opioid receptor mu (MOP) DM9PGQI MT DTT DM9PGQI MA Inhibitor DM9PGQI RN Opiate receptor binding properties of morphine-, dihydromorphine-, and codeine 6-O-sulfate ester congeners. Bioorg Med Chem Lett. 2006 Aug 15;16(16):4291-5. DM9PGQI RU https://pubmed.ncbi.nlm.nih.gov/16777416 DMUL4PE DI DMUL4PE DMUL4PE DN MMB-4 DMUL4PE MI TT1RS9F DMUL4PE MN Acetylcholinesterase (AChE) DMUL4PE MT DTT DMUL4PE MA Activator DMUL4PE RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2465). DMUL4PE RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2465 DMUWVGP DI DMUWVGP DMUWVGP DN MMDA DMUWVGP MI TTJQOD7 DMUWVGP MN 5-HT 2A receptor (HTR2A) DMUWVGP MT DTT DMUWVGP MA Agonist DMUWVGP RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMUWVGP RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMUWVGP DI DMUWVGP DMUWVGP DN MMDA DMUWVGP MI TTVBI8W DMUWVGP MN Dopamine transporter (DAT) DMUWVGP MT DTT DMUWVGP MA Modulator DMUWVGP RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMUWVGP RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMUWVGP DI DMUWVGP DMUWVGP DN MMDA DMUWVGP MI TT3WG5C DMUWVGP MN Monoamine oxidase type A (MAO-A) DMUWVGP MT DTT DMUWVGP MA Antagonist DMUWVGP RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMUWVGP RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMUWVGP DI DMUWVGP DMUWVGP DN MMDA DMUWVGP MI TTGP7BY DMUWVGP MN Monoamine oxidase type B (MAO-B) DMUWVGP MT DTT DMUWVGP MA Antagonist DMUWVGP RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMUWVGP RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMUWVGP DI DMUWVGP DMUWVGP DN MMDA DMUWVGP MI TTAWNKZ DMUWVGP MN Norepinephrine transporter (NET) DMUWVGP MT DTT DMUWVGP MA Modulator DMUWVGP RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMUWVGP RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMUWVGP DI DMUWVGP DMUWVGP DN MMDA DMUWVGP MI TT3ROYC DMUWVGP MN Serotonin transporter (SERT) DMUWVGP MT DTT DMUWVGP MA Modulator DMUWVGP RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMUWVGP RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMUWVGP DI DMUWVGP DMUWVGP DN MMDA DMUWVGP MI TTNZRI3 DMUWVGP MN Synaptic vesicle amine transporter (SLC18A2) DMUWVGP MT DTT DMUWVGP MA Antagonist DMUWVGP RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMUWVGP RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMH1YN6 DI DMH1YN6 DMH1YN6 DN MMI-175 DMH1YN6 MI TT8JRS7 DMH1YN6 MN Beta-secretase (BACE) DMH1YN6 MT DTT DMH1YN6 MA Inhibitor DMH1YN6 RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMH1YN6 RU https://pubmed.ncbi.nlm.nih.gov/17139284 DM38N2K DI DM38N2K DM38N2K DN MMI270 DM38N2K MI TTYG6BU DM38N2K MN Aggrecanase-1 (ADAMTS4) DM38N2K MT DTT DM38N2K MA Inhibitor DM38N2K RN Synthesis and biological evaluation of biphenylsulfonamide carboxylate aggrecanase-1 inhibitors. Bioorg Med Chem Lett. 2006 Jan 15;16(2):311-6. DM38N2K RU https://pubmed.ncbi.nlm.nih.gov/16275085 DM38N2K DI DM38N2K DM38N2K DN MMI270 DM38N2K MI TTIQSC1 DM38N2K MN Bacterial Lethal factor (Bact lef) DM38N2K MT DTT DM38N2K MA Inhibitor DM38N2K RN The discovery of a potent and selective lethal factor inhibitor for adjunct therapy of anthrax infection. Bioorg Med Chem Lett. 2006 Feb 15;16(4):964-8. DM38N2K RU https://pubmed.ncbi.nlm.nih.gov/16338135 DM38N2K DI DM38N2K DM38N2K DN MMI270 DM38N2K MI TTANPDJ DM38N2K MN Carbonic anhydrase II (CA-II) DM38N2K MT DTT DM38N2K MA Inhibitor DM38N2K RN Carbonic anhydrase and matrix metalloproteinase inhibitors. Inhibition of human tumor-associated isozymes IX and cytosolic isozyme I and II with su... Bioorg Med Chem. 2007 Mar 15;15(6):2298-311. DM38N2K RU https://pubmed.ncbi.nlm.nih.gov/17276072 DM38N2K DI DM38N2K DM38N2K DN MMI270 DM38N2K MI TT2LVK8 DM38N2K MN Carbonic anhydrase IX (CA-IX) DM38N2K MT DTT DM38N2K MA Inhibitor DM38N2K RN Carbonic anhydrase and matrix metalloproteinase inhibitors. Inhibition of human tumor-associated isozymes IX and cytosolic isozyme I and II with su... Bioorg Med Chem. 2007 Mar 15;15(6):2298-311. DM38N2K RU https://pubmed.ncbi.nlm.nih.gov/17276072 DM38N2K DI DM38N2K DM38N2K DN MMI270 DM38N2K MI TTMX39J DM38N2K MN Matrix metalloproteinase-1 (MMP-1) DM38N2K MT DTT DM38N2K MA Inhibitor DM38N2K RN The discovery of a potent and selective lethal factor inhibitor for adjunct therapy of anthrax infection. Bioorg Med Chem Lett. 2006 Feb 15;16(4):964-8. DM38N2K RU https://pubmed.ncbi.nlm.nih.gov/16338135 DM38N2K DI DM38N2K DM38N2K DN MMI270 DM38N2K MI TTHY57M DM38N2K MN Matrix metalloproteinase-13 (MMP-13) DM38N2K MT DTT DM38N2K MA Inhibitor DM38N2K RN Heterocycle-based MMP inhibitors with P2' substituents. Bioorg Med Chem Lett. 2001 Apr 23;11(8):1009-13. DM38N2K RU https://pubmed.ncbi.nlm.nih.gov/11327577 DM38N2K DI DM38N2K DM38N2K DN MMI270 DM38N2K MI TTJ4QE7 DM38N2K MN Matrix metalloproteinase-14 (MMP-14) DM38N2K MT DTT DM38N2K MA Inhibitor DM38N2K RN Methotrexate gamma-hydroxamate derivatives as potential dual target antitumor drugs. Bioorg Med Chem. 2007 Feb 1;15(3):1266-74. DM38N2K RU https://pubmed.ncbi.nlm.nih.gov/17127067 DM38N2K DI DM38N2K DM38N2K DN MMI270 DM38N2K MI TTLM12X DM38N2K MN Matrix metalloproteinase-2 (MMP-2) DM38N2K MT DTT DM38N2K MA Inhibitor DM38N2K RN Picking the S1, S1' and S2' pockets of matrix metalloproteinases. A niche for potent acyclic sulfonamide inhibitors. Bioorg Med Chem Lett. 1999 Jun 21;9(12):1691-6. DM38N2K RU https://pubmed.ncbi.nlm.nih.gov/10397503 DM38N2K DI DM38N2K DM38N2K DN MMI270 DM38N2K MI TTUZ2L5 DM38N2K MN Matrix metalloproteinase-3 (MMP-3) DM38N2K MT DTT DM38N2K MA Inhibitor DM38N2K RN Strategies for MMP inhibition in cancer: innovations for the post-trial era. Nat Rev Cancer. 2002 Sep;2(9):657-72. DM38N2K RU https://pubmed.ncbi.nlm.nih.gov/12209155 DM38N2K DI DM38N2K DM38N2K DN MMI270 DM38N2K MI TTMTWOS DM38N2K MN Matrix metalloproteinase-7 (MMP-7) DM38N2K MT DTT DM38N2K MA Inhibitor DM38N2K RN Methotrexate gamma-hydroxamate derivatives as potential dual target antitumor drugs. Bioorg Med Chem. 2007 Feb 1;15(3):1266-74. DM38N2K RU https://pubmed.ncbi.nlm.nih.gov/17127067 DM38N2K DI DM38N2K DM38N2K DN MMI270 DM38N2K MI TTGA1IV DM38N2K MN Matrix metalloproteinase-8 (MMP-8) DM38N2K MT DTT DM38N2K MA Inhibitor DM38N2K RN Design, synthesis, and biological evaluation of potent thiazine- and thiazepine-based matrix metalloproteinase inhibitors. J Med Chem. 1999 Nov 4;42(22):4547-62. DM38N2K RU https://pubmed.ncbi.nlm.nih.gov/10579818 DM38N2K DI DM38N2K DM38N2K DN MMI270 DM38N2K MI TT6X50U DM38N2K MN Matrix metalloproteinase-9 (MMP-9) DM38N2K MT DTT DM38N2K MA Inhibitor DM38N2K RN Picking the S1, S1' and S2' pockets of matrix metalloproteinases. A niche for potent acyclic sulfonamide inhibitors. Bioorg Med Chem Lett. 1999 Jun 21;9(12):1691-6. DM38N2K RU https://pubmed.ncbi.nlm.nih.gov/10397503 DMVCNBH DI DMVCNBH DMVCNBH DN MMP-408 DMVCNBH MI TTXZ0KQ DMVCNBH MN Matrix metalloproteinase-12 (MMP-12) DMVCNBH MT DTT DMVCNBH MA Inhibitor DMVCNBH RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1636). DMVCNBH RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1636 DMWMZL7 DI DMWMZL7 DMWMZL7 DN MMPIP DMWMZL7 MI TT0I76D DMWMZL7 MN Metabotropic glutamate receptor 7 (mGluR7) DMWMZL7 MT DTT DMWMZL7 MA Modulator (allosteric modulator) DMWMZL7 RN Context-dependent pharmacology exhibited by negative allosteric modulators of metabotropic glutamate receptor 7. Mol Pharmacol. 2010 Mar;77(3):459-68. DMWMZL7 RU https://pubmed.ncbi.nlm.nih.gov/20026717 DM1XY5F DI DM1XY5F DM1XY5F DN MN-462 DM1XY5F MI TTP18AY DM1XY5F MN Carboxypeptidase B2 (CPB2) DM1XY5F MT DTT DM1XY5F MA Inhibitor DM1XY5F RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1594). DM1XY5F RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1594 DMBJFH9 DI DMBJFH9 DMBJFH9 DN MNI-135 DMBJFH9 MI TTXJ47W DMBJFH9 MN Metabotropic glutamate receptor 2 (mGluR2) DMBJFH9 MT DTT DMBJFH9 MA Modulator (allosteric modulator) DMBJFH9 RN A novel family of potent negative allosteric modulators of group II metabotropic glutamate receptors. J Pharmacol Exp Ther. 2007 Jul;322(1):254-64. DMBJFH9 RU https://pubmed.ncbi.nlm.nih.gov/17416742 DMBJFH9 DI DMBJFH9 DMBJFH9 DN MNI-135 DMBJFH9 MI TT8A9EF DMBJFH9 MN Metabotropic glutamate receptor 3 (mGluR3) DMBJFH9 MT DTT DMBJFH9 MA Modulator (allosteric modulator) DMBJFH9 RN A novel family of potent negative allosteric modulators of group II metabotropic glutamate receptors. J Pharmacol Exp Ther. 2007 Jul;322(1):254-64. DMBJFH9 RU https://pubmed.ncbi.nlm.nih.gov/17416742 DM5C9VI DI DM5C9VI DM5C9VI DN MNI-136 DM5C9VI MI TTXJ47W DM5C9VI MN Metabotropic glutamate receptor 2 (mGluR2) DM5C9VI MT DTT DM5C9VI MA Modulator (allosteric modulator) DM5C9VI RN A novel family of potent negative allosteric modulators of group II metabotropic glutamate receptors. J Pharmacol Exp Ther. 2007 Jul;322(1):254-64. DM5C9VI RU https://pubmed.ncbi.nlm.nih.gov/17416742 DM5C9VI DI DM5C9VI DM5C9VI DN MNI-136 DM5C9VI MI TT8A9EF DM5C9VI MN Metabotropic glutamate receptor 3 (mGluR3) DM5C9VI MT DTT DM5C9VI MA Modulator (allosteric modulator) DM5C9VI RN A novel family of potent negative allosteric modulators of group II metabotropic glutamate receptors. J Pharmacol Exp Ther. 2007 Jul;322(1):254-64. DM5C9VI RU https://pubmed.ncbi.nlm.nih.gov/17416742 DMKRI1J DI DMKRI1J DMKRI1J DN MNI-137 DMKRI1J MI TTXJ47W DMKRI1J MN Metabotropic glutamate receptor 2 (mGluR2) DMKRI1J MT DTT DMKRI1J MA Modulator (allosteric modulator) DMKRI1J RN A novel family of potent negative allosteric modulators of group II metabotropic glutamate receptors. J Pharmacol Exp Ther. 2007 Jul;322(1):254-64. DMKRI1J RU https://pubmed.ncbi.nlm.nih.gov/17416742 DMKRI1J DI DMKRI1J DMKRI1J DN MNI-137 DMKRI1J MI TT8A9EF DMKRI1J MN Metabotropic glutamate receptor 3 (mGluR3) DMKRI1J MT DTT DMKRI1J MA Modulator (allosteric modulator) DMKRI1J RN A novel family of potent negative allosteric modulators of group II metabotropic glutamate receptors. J Pharmacol Exp Ther. 2007 Jul;322(1):254-64. DMKRI1J RU https://pubmed.ncbi.nlm.nih.gov/17416742 DMLYVQB DI DMLYVQB DMLYVQB DN MOD-3012 DMLYVQB MI TTFEZ5Q DMLYVQB MN Coagulation factor IX (F9) DMLYVQB MT DTT DMLYVQB MA Modulator DMLYVQB RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2364). DMLYVQB RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2364 DMKWBNA DI DMKWBNA DMKWBNA DN MOD-5023 DMKWBNA MI TTF0EGX DMKWBNA MN Coagulation factor VII (F7) DMKWBNA MT DTT DMKWBNA MA Modulator DMKWBNA RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2363). DMKWBNA RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2363 DMB5OG8 DI DMB5OG8 DMB5OG8 DN modified HA14-1 compounds (cancer) DMB5OG8 MI TTJGNVC DMB5OG8 MN Apoptosis regulator Bcl-2 (BCL-2) DMB5OG8 MT DTT DMB5OG8 MA Modulator DMB5OG8 RN The small-molecule Bcl-2 inhibitor HA14-1 interacts synergistically with flavopiridol to induce mitochondrial injury and apoptosis in human myeloma cells through a free radical-dependent and Jun NH2-terminal kinase-dependent mechanism. Mol Cancer Ther. 2004 Dec;3(12):1513-24. DMB5OG8 RU https://pubmed.ncbi.nlm.nih.gov/15634644 DMPYBHI DI DMPYBHI DMPYBHI DN moexiprilat DMPYBHI MI TTL69WB DMPYBHI MN Angiotensin-converting enzyme (ACE) DMPYBHI MT DTT DMPYBHI MA Modulator DMPYBHI RN Moexipril, a new angiotensin-converting enzyme (ACE) inhibitor: pharmacological characterization and comparison with enalapril. J Pharmacol Exp Ther. 1995 Nov;275(2):854-63. DMPYBHI RU https://www.ncbi.nlm.nih.gov/pubmed/7473177 DMSF8UC DI DMSF8UC DMSF8UC DN MOL 6131 DMSF8UC MI TTM1TDX DMSF8UC MN Tryptase alpha/beta-1 (Tryptase) DMSF8UC MT DTT DMSF8UC MA Inhibitor DMSF8UC RN Tryptase inhibition blocks airway inflammation in a mouse asthma model. J Immunol. 2002 Feb 15;168(4):1992-2000. DMSF8UC RU https://pubmed.ncbi.nlm.nih.gov/11823536 DM0OWTS DI DM0OWTS DM0OWTS DN MOLASSAMIDE DM0OWTS MI TT3NKIB DM0OWTS MN Pancreatic elastase 1 (CELA1) DM0OWTS MT DTT DM0OWTS MA Inhibitor DM0OWTS RN Molassamide, a depsipeptide serine protease inhibitor from the marine cyanobacterium Dichothrix utahensis. J Nat Prod. 2010 Mar 26;73(3):459-62. DM0OWTS RU https://pubmed.ncbi.nlm.nih.gov/20020755 DMZ6H1X DI DMZ6H1X DMZ6H1X DN Molecule 11 DMZ6H1X MI TTCIHJA DMZ6H1X MN Coagulation factor Xa (F10) DMZ6H1X MT DTT DMZ6H1X MA Inhibitor DMZ6H1X RN Role of tissue factor pathway inhibitor in the regulation of tissue factor-dependent blood coagulation. Cardiovasc Drug Rev. 2002 Winter;20(1):67-80. DMZ6H1X RU https://pubmed.ncbi.nlm.nih.gov/12070535 DMA7T0N DI DMA7T0N DMA7T0N DN Molecule 21 DMA7T0N MI TTPNGDE DMA7T0N MN Prostaglandin E2 receptor EP3 (PTGER3) DMA7T0N MT DTT DMA7T0N MA Antagonist DMA7T0N RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 342). DMA7T0N RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=342 DM4OLAZ DI DM4OLAZ DM4OLAZ DN MOLEPHANTIN DM4OLAZ MI TTSXVID DM4OLAZ MN Nuclear factor NF-kappa-B (NFKB) DM4OLAZ MT DTT DM4OLAZ MA Inhibitor DM4OLAZ RN Quantitative structure-activity relationship of sesquiterpene lactones as inhibitors of the transcription factor NF-kappaB. J Med Chem. 2004 Nov 18;47(24):6042-54. DM4OLAZ RU https://pubmed.ncbi.nlm.nih.gov/15537359 DMGNX6M DI DMGNX6M DMGNX6M DN MOLEPHANTININ DMGNX6M MI TTSXVID DMGNX6M MN Nuclear factor NF-kappa-B (NFKB) DMGNX6M MT DTT DMGNX6M MA Inhibitor DMGNX6M RN Quantitative structure-activity relationship of sesquiterpene lactones as inhibitors of the transcription factor NF-kappaB. J Med Chem. 2004 Nov 18;47(24):6042-54. DMGNX6M RU https://pubmed.ncbi.nlm.nih.gov/15537359 DMLSEJN DI DMLSEJN DMLSEJN DN Monastrol DMLSEJN MI TTTRP0H DMLSEJN MN Kinesin-like protein KIF11 (KIF11) DMLSEJN MT DTT DMLSEJN MA Inhibitor DMLSEJN RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMLSEJN RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMNWCPB DI DMNWCPB DMNWCPB DN Monocarboxylic acids DMNWCPB MI DT8ZFIO DMNWCPB MN Monocarboxylate transporter 7 (SLC16A6) DMNWCPB MT DTP DMNWCPB MA Substrate DMNWCPB RN The Monocarboxylate Transporter SLC16A6 Regulates Adult Length in Zebrafish and Is Associated With Height in Humans. Front Physiol. 2019 Jan 14;9:1936. DMNWCPB RU http://www.ncbi.nlm.nih.gov/pubmed/30692937 DM31YGM DI DM31YGM DM31YGM DN Monoctanoin component C DM31YGM MI TTRFOXJ DM31YGM MN Protein kinase C gamma (PRKCG) DM31YGM MT DTT DM31YGM MA Inhibitor DM31YGM RN Synthesis and characterization of the second cysteine-rich region of mouse skin PKCGh, Bioorg. Med. Chem. Lett. 6(4):353-356 (1996). DM31YGM RU http://www.sciencedirect.com/science/article/pii/0960894X96000261 DM59CR0 DI DM59CR0 DM59CR0 DN MONODICTYOCHROMONE B DM59CR0 MI TTSZLWK DM59CR0 MN Aromatase (CYP19A1) DM59CR0 MT DTT DM59CR0 MA Inhibitor DM59CR0 RN Monodictyochromes A and B, dimeric xanthone derivatives from the marine algicolous fungus Monodictys putredinis. J Nat Prod. 2008 Nov;71(11):1793-9. DM59CR0 RU https://pubmed.ncbi.nlm.nih.gov/18939864 DMNJXHF DI DMNJXHF DMNJXHF DN Monoisopropyl Ester Phosphonic Acid Group DMNJXHF MI TTEB0GD DMNJXHF MN Cholinesterase (BCHE) DMNJXHF MT DTT DMNJXHF MA Inhibitor DMNJXHF RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMNJXHF RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMNJXHF DI DMNJXHF DMNJXHF DN Monoisopropyl Ester Phosphonic Acid Group DMNJXHF MI TT5DOVB DMNJXHF MN Cytomegalovirus Protease (CMV UL80) DMNJXHF MT DTT DMNJXHF MA Inhibitor DMNJXHF RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMNJXHF RU https://pubmed.ncbi.nlm.nih.gov/17139284 DM0OFT6 DI DM0OFT6 DM0OFT6 DN Monoisopropylphosphorylserine DM0OFT6 MI TT1RS9F DM0OFT6 MN Acetylcholinesterase (AChE) DM0OFT6 MT DTT DM0OFT6 MA Inhibitor DM0OFT6 RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DM0OFT6 RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMU4JWM DI DMU4JWM DMU4JWM DN monomethylfumarate DMU4JWM MI TTWNV8U DMU4JWM MN Nicotinic acid receptor (HCAR2) DMU4JWM MT DTT DMU4JWM MA Agonist DMU4JWM RN The psoriasis drug monomethylfumarate is a potent nicotinic acid receptor agonist. Biochem Biophys Res Commun. 2008 Oct 31;375(4):562-5. DMU4JWM RU https://pubmed.ncbi.nlm.nih.gov/18722346 DM4QO9G DI DM4QO9G DM4QO9G DN Mononitrophenol DM4QO9G MI DE4OGUF DM4QO9G MN Cytochrome P450 102A1 (cyp102) DM4QO9G MT DME DM4QO9G MA Metabolism DM4QO9G RN nan DM4QO9G RU nan DM4QO9G DI DM4QO9G DM4QO9G DN Mononitrophenol DM4QO9G MI DE0K82S DM4QO9G MN Nitroreductase (NTR) DM4QO9G MT DME DM4QO9G MA Metabolism DM4QO9G RN nan DM4QO9G RU nan DM4QO9G DI DM4QO9G DM4QO9G DN Mononitrophenol DM4QO9G MI DERUZL7 DM4QO9G MN Sulfotransferase 1A2 (SULT1A2) DM4QO9G MT DME DM4QO9G MA Metabolism DM4QO9G RN cDNA cloning and expression of a new form of human aryl sulfotransferase. Int J Biochem Cell Biol. 1996 May;28(5):565-71. DM4QO9G RU https://www.ncbi.nlm.nih.gov/pubmed/?term=8697101 DM4QO9G DI DM4QO9G DM4QO9G DN Mononitrophenol DM4QO9G MI DED5UR3 DM4QO9G MN Sulfotransferase 1B1 (SULT1B1) DM4QO9G MT DME DM4QO9G MA Metabolism DM4QO9G RN Comparison of 2-aminophenol and 4-nitrophenol as in vitro probe substrates for the major human hepatic sulfotransferase, SULT1A1, demonstrates improved selectivity with 2-aminophenol. Biochem Pharmacol. 2007 Jul 15;74(2):352-8. DM4QO9G RU https://www.ncbi.nlm.nih.gov/pubmed/?term=17506995 DMENSOZ DI DMENSOZ DMENSOZ DN Monothioglycerol DMENSOZ MI TTNGKET DMENSOZ MN Prolyl endopeptidase (PREP) DMENSOZ MT DTT DMENSOZ MA Inhibitor DMENSOZ RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMENSOZ RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMWR0J1 DI DMWR0J1 DMWR0J1 DN MORACHALCONE A DMWR0J1 MI TTSZLWK DMWR0J1 MN Aromatase (CYP19A1) DMWR0J1 MT DTT DMWR0J1 MA Inhibitor DMWR0J1 RN Aromatase inhibitors from Broussonetia papyrifera. J Nat Prod. 2001 Oct;64(10):1286-93. DMWR0J1 RU https://pubmed.ncbi.nlm.nih.gov/11678652 DM2OGZ5 DI DM2OGZ5 DM2OGZ5 DN Morin DM2OGZ5 MI TTOM3J0 DM2OGZ5 MN Estrogen receptor beta (ESR2) DM2OGZ5 MT DTT DM2OGZ5 MA Inhibitor DM2OGZ5 RN In silico identification and biochemical evaluation of novel inhibitors of NRH:quinone oxidoreductase 2 (NQO2). Bioorg Med Chem Lett. 2010 Dec 15;20(24):7331-6. DM2OGZ5 RU https://pubmed.ncbi.nlm.nih.gov/21074425 DM2OGZ5 DI DM2OGZ5 DM2OGZ5 DN Morin DM2OGZ5 MI TT7AOUD DM2OGZ5 MN Fatty acid synthase (FASN) DM2OGZ5 MT DTT DM2OGZ5 MA Inhibitor DM2OGZ5 RN Inhibition of Plasmodium falciparum fatty acid biosynthesis: evaluation of FabG, FabZ, and FabI as drug targets for flavonoids. J Med Chem. 2006 Jun 1;49(11):3345-53. DM2OGZ5 RU https://pubmed.ncbi.nlm.nih.gov/16722653 DM2OGZ5 DI DM2OGZ5 DM2OGZ5 DN Morin DM2OGZ5 MI TTL53M6 DM2OGZ5 MN Induced myeloid leukemia cell differentiation protein Mcl-1 (MCL1) DM2OGZ5 MT DTT DM2OGZ5 MA Inhibitor DM2OGZ5 RN In silico identification and biochemical evaluation of novel inhibitors of NRH:quinone oxidoreductase 2 (NQO2). Bioorg Med Chem Lett. 2010 Dec 15;20(24):7331-6. DM2OGZ5 RU https://pubmed.ncbi.nlm.nih.gov/21074425 DM2OGZ5 DI DM2OGZ5 DM2OGZ5 DN Morin DM2OGZ5 MI TTHPFTS DM2OGZ5 MN Plasmodium Beta-hydroxyacyl-ACP dehydratase (Malaria FabZ) DM2OGZ5 MT DTT DM2OGZ5 MA Inhibitor DM2OGZ5 RN Inhibition of Plasmodium falciparum fatty acid biosynthesis: evaluation of FabG, FabZ, and FabI as drug targets for flavonoids. J Med Chem. 2006 Jun 1;49(11):3345-53. DM2OGZ5 RU https://pubmed.ncbi.nlm.nih.gov/16722653 DM2OGZ5 DI DM2OGZ5 DM2OGZ5 DN Morin DM2OGZ5 MI TTNX2CS DM2OGZ5 MN Plasmodium Enoyl-ACP reductase (Malaria fabI) DM2OGZ5 MT DTT DM2OGZ5 MA Inhibitor DM2OGZ5 RN Inhibition of Plasmodium falciparum fatty acid biosynthesis: evaluation of FabG, FabZ, and FabI as drug targets for flavonoids. J Med Chem. 2006 Jun 1;49(11):3345-53. DM2OGZ5 RU https://pubmed.ncbi.nlm.nih.gov/16722653 DM2OGZ5 DI DM2OGZ5 DM2OGZ5 DN Morin DM2OGZ5 MI TTBE4IR DM2OGZ5 MN Plasmodium Oxoacyl-[acyl-carrier protein] reductase (Malaria fabG) DM2OGZ5 MT DTT DM2OGZ5 MA Inhibitor DM2OGZ5 RN Inhibition of Plasmodium falciparum fatty acid biosynthesis: evaluation of FabG, FabZ, and FabI as drug targets for flavonoids. J Med Chem. 2006 Jun 1;49(11):3345-53. DM2OGZ5 RU https://pubmed.ncbi.nlm.nih.gov/16722653 DM2OGZ5 DI DM2OGZ5 DM2OGZ5 DN Morin DM2OGZ5 MI TTA592U DM2OGZ5 MN Urate anion exchanger 1 (URAT1) DM2OGZ5 MT DTT DM2OGZ5 MA Inhibitor DM2OGZ5 RN Morin (3,5,7,2',4'-pentahydroxyflavone) exhibits potent inhibitory actions on urate transport by the human urate anion transporter (hURAT1) express... Drug Metab Dispos. 2007 Jun;35(6):981-6. DM2OGZ5 RU https://pubmed.ncbi.nlm.nih.gov/17325024 DMB91UL DI DMB91UL DMB91UL DN morphanthridine DMB91UL MI TTELV3W DMB91UL MN Transformation-sensitive protein p120 (TRPA1) DMB91UL MT DTT DMB91UL MA Activator DMB91UL RN Tear gasses CN, CR, and CS are potent activators of the human TRPA1 receptor. Toxicol Appl Pharmacol. 2008 Sep 1;231(2):150-6. DMB91UL RU https://pubmed.ncbi.nlm.nih.gov/18501939 DM9A1RY DI DM9A1RY DM9A1RY DN MORPHICEPTIN DM9A1RY MI TTKWM86 DM9A1RY MN Opioid receptor mu (MOP) DM9A1RY MT DTT DM9A1RY MA Inhibitor DM9A1RY RN Synthesis and activity of endomorphin-2 and morphiceptin analogues with proline surrogates in position 2. Eur J Med Chem. 2010 Oct;45(10):4594-600. DM9A1RY RU https://pubmed.ncbi.nlm.nih.gov/20692738 DMTHFSE DI DMTHFSE DMTHFSE DN Morphinan Cyclic Imine analogue DMTHFSE MI TTQW87Y DMTHFSE MN Opioid receptor kappa (OPRK1) DMTHFSE MT DTT DMTHFSE MA Inhibitor DMTHFSE RN Morphinan cyclic imines and pyrrolidines containing a constrained phenyl group: High affinity opioid agonists, Bioorg. Med. Chem. Lett. 5(24):2969-2974 (1995). DMTHFSE RU http://www.sciencedirect.com/science/article/pii/0960894X95005221 DM9LQIA DI DM9LQIA DM9LQIA DN MORPHINONE DM9LQIA MI TTKWM86 DM9LQIA MN Opioid receptor mu (MOP) DM9LQIA MT DTT DM9LQIA MA Inhibitor DM9LQIA RN Live cell monitoring of mu-opioid receptor-mediated G-protein activation reveals strong biological activity of close morphine biosynthetic precursors. J Biol Chem. 2007 Sep 14;282(37):27126-32. DM9LQIA RU https://pubmed.ncbi.nlm.nih.gov/17616524 DM05L3S DI DM05L3S DM05L3S DN Morpholino(1'H-phenothiazin-1'-yl)methanone DM05L3S MI TTEB0GD DM05L3S MN Cholinesterase (BCHE) DM05L3S MT DTT DM05L3S MA Inhibitor DM05L3S RN Differential binding of phenothiazine urea derivatives to wild-type human cholinesterases and butyrylcholinesterase mutants. Bioorg Med Chem. 2010 Mar 15;18(6):2232-2244. DM05L3S RU https://pubmed.ncbi.nlm.nih.gov/20181484 DMV5T1I DI DMV5T1I DMV5T1I DN MP-529 DMV5T1I MI TTLYXIT DMV5T1I MN Aurora kinase C (AURKC) DMV5T1I MT DTT DMV5T1I MA Inhibitor DMV5T1I RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1936). DMV5T1I RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1936 DMONDP1 DI DMONDP1 DMONDP1 DN MPC-MECA DMONDP1 MI TTJFY5U DMONDP1 MN Adenosine A3 receptor (ADORA3) DMONDP1 MT DTT DMONDP1 MA Agonist DMONDP1 RN [(3)H]MRE 3008F20: a novel antagonist radioligand for the pharmacological and biochemical characterization of human A(3) adenosine receptors. Mol Pharmacol. 2000 May;57(5):968-75. DMONDP1 RU https://pubmed.ncbi.nlm.nih.gov/10779381 DMYX31S DI DMYX31S DMYX31S DN MPDT DMYX31S MI TTSQIFT DMYX31S MN 5-HT 1A receptor (HTR1A) DMYX31S MT DTT DMYX31S MA Antagonist DMYX31S RN 2-Substituted tryptamines: agents with selectivity for 5-HT(6) serotonin receptors. J Med Chem. 2000 Mar 9;43(5):1011-8. DMYX31S RU https://pubmed.ncbi.nlm.nih.gov/10715164 DMYX31S DI DMYX31S DMYX31S DN MPDT DMYX31S MI TT6MSOK DMYX31S MN 5-HT 1D receptor (HTR1D) DMYX31S MT DTT DMYX31S MA Antagonist DMYX31S RN 2-Substituted tryptamines: agents with selectivity for 5-HT(6) serotonin receptors. J Med Chem. 2000 Mar 9;43(5):1011-8. DMYX31S RU https://pubmed.ncbi.nlm.nih.gov/10715164 DMYX31S DI DMYX31S DMYX31S DN MPDT DMYX31S MI TTJQOD7 DMYX31S MN 5-HT 2A receptor (HTR2A) DMYX31S MT DTT DMYX31S MA Antagonist DMYX31S RN 2-Substituted tryptamines: agents with selectivity for 5-HT(6) serotonin receptors. J Med Chem. 2000 Mar 9;43(5):1011-8. DMYX31S RU https://pubmed.ncbi.nlm.nih.gov/10715164 DMYX31S DI DMYX31S DMYX31S DN MPDT DMYX31S MI TTWJBZ5 DMYX31S MN 5-HT 2C receptor (HTR2C) DMYX31S MT DTT DMYX31S MA Antagonist DMYX31S RN 2-Substituted tryptamines: agents with selectivity for 5-HT(6) serotonin receptors. J Med Chem. 2000 Mar 9;43(5):1011-8. DMYX31S RU https://pubmed.ncbi.nlm.nih.gov/10715164 DMYX31S DI DMYX31S DMYX31S DN MPDT DMYX31S MI TTRUFDT DMYX31S MN 5-HT 5A receptor (HTR5A) DMYX31S MT DTT DMYX31S MA Antagonist DMYX31S RN 2-Substituted tryptamines: agents with selectivity for 5-HT(6) serotonin receptors. J Med Chem. 2000 Mar 9;43(5):1011-8. DMYX31S RU https://pubmed.ncbi.nlm.nih.gov/10715164 DMYX31S DI DMYX31S DMYX31S DN MPDT DMYX31S MI TTJS8PY DMYX31S MN 5-HT 6 receptor (HTR6) DMYX31S MT DTT DMYX31S MA Antagonist DMYX31S RN 2-Substituted tryptamines: agents with selectivity for 5-HT(6) serotonin receptors. J Med Chem. 2000 Mar 9;43(5):1011-8. DMYX31S RU https://pubmed.ncbi.nlm.nih.gov/10715164 DMYX31S DI DMYX31S DMYX31S DN MPDT DMYX31S MI TTO9X1H DMYX31S MN 5-HT 7 receptor (HTR7) DMYX31S MT DTT DMYX31S MA Antagonist DMYX31S RN 2-Substituted tryptamines: agents with selectivity for 5-HT(6) serotonin receptors. J Med Chem. 2000 Mar 9;43(5):1011-8. DMYX31S RU https://pubmed.ncbi.nlm.nih.gov/10715164 DMJRK47 DI DMJRK47 DMJRK47 DN M-Phenoxybenzoic Acid For Cis-Isomer DMJRK47 MI TT5ZWB6 DMJRK47 MN Dihydrodiol dehydrogenase type I (AKR1C3) DMJRK47 MT DTT DMJRK47 MA Inhibitor DMJRK47 RN Nonsteroidal anti-inflammatory drugs and their analogues as inhibitors of aldo-keto reductase AKR1C3: new lead compounds for the development of ant... Bioorg Med Chem Lett. 2005 Dec 1;15(23):5170-5. DMJRK47 RU https://pubmed.ncbi.nlm.nih.gov/16183274 DMJHQ9T DI DMJHQ9T DMJHQ9T DN MPPG DMJHQ9T MI TTICZ1O DMJHQ9T MN Metabotropic glutamate receptor 4 (mGluR4) DMJHQ9T MT DTT DMJHQ9T MA Antagonist DMJHQ9T RN Ligand binding to the amino-terminal domain of the mGluR4 subtype of metabotropic glutamate receptor. J Biol Chem. 1999 Apr 9;274(15):10008-13. DMJHQ9T RU https://pubmed.ncbi.nlm.nih.gov/10187777 DMJHQ9T DI DMJHQ9T DMJHQ9T DN MPPG DMJHQ9T MI TTWRP2F DMJHQ9T MN Metabotropic glutamate receptor 6 (mGluR6) DMJHQ9T MT DTT DMJHQ9T MA Antagonist DMJHQ9T RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 294). DMJHQ9T RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=294 DMJHQ9T DI DMJHQ9T DMJHQ9T DN MPPG DMJHQ9T MI TT0I76D DMJHQ9T MN Metabotropic glutamate receptor 7 (mGluR7) DMJHQ9T MT DTT DMJHQ9T MA Antagonist DMJHQ9T RN Binding of [3H](2S,1'S,2'S)-2-(9-xanthylmethyl)-2-(2'-carboxycyclopropyl) glycine ([3H]LY341495) to cell membranes expressing recombinant human group III metabotropic glutamate receptor subtypes. Naunyn Schmiedebergs Arch Pharmacol. 2000 Dec;362(6):546-54. DMJHQ9T RU https://pubmed.ncbi.nlm.nih.gov/11138847 DMJHQ9T DI DMJHQ9T DMJHQ9T DN MPPG DMJHQ9T MI TT0IFKL DMJHQ9T MN Metabotropic glutamate receptor 8 (mGluR8) DMJHQ9T MT DTT DMJHQ9T MA Antagonist DMJHQ9T RN Group III human metabotropic glutamate receptors 4, 7 and 8: molecular cloning, functional expression, and comparison of pharmacological properties in RGT cells. Brain Res Mol Brain Res. 1998 Jan;53(1-2):88-97. DMJHQ9T RU https://pubmed.ncbi.nlm.nih.gov/9473604 DMFKG7C DI DMFKG7C DMFKG7C DN MP-RM-1 DMFKG7C MI TTDC8N2 DMFKG7C MN Erbb3 tyrosine kinase receptor (Erbb-3) DMFKG7C MT DTT DMFKG7C RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1798). DMFKG7C RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1798 DMWUK9G DI DMWUK9G DMWUK9G DN MPrP DMWUK9G MI TTZAYWL DMWUK9G MN Estrogen receptor (ESR) DMWUK9G MT DTT DMWUK9G MA Inhibitor DMWUK9G RN Analogs of methyl-piperidinopyrazole (MPP): antiestrogens with estrogen receptor alpha selective activity. Bioorg Med Chem Lett. 2009 Jan 1;19(1):108-10. DMWUK9G RU https://pubmed.ncbi.nlm.nih.gov/19014882 DMQ357C DI DMQ357C DMQ357C DN MQ1 DMQ357C MI TTX4RTB DMQ357C MN Melanin-concentrating hormone receptor 1 (MCHR1) DMQ357C MT DTT DMQ357C MA Modulator (allosteric modulator) DMQ357C RN The MCH(1) receptor, an anti-obesity target, is allosterically inhibited by 8-methylquinoline derivatives possessing subnanomolar binding and long residence times. Br J Pharmacol. 2014 Mar;171(5):1287-98. DMQ357C RU https://pubmed.ncbi.nlm.nih.gov/24670150 DMS7FC6 DI DMS7FC6 DMS7FC6 DN MR-1029 DMS7FC6 MI TTQW87Y DMS7FC6 MN Opioid receptor kappa (OPRK1) DMS7FC6 MT DTT DMS7FC6 MA Inhibitor DMS7FC6 RN Electrophilic gamma-lactone kappa-opioid receptor probes. Analogues of 2'-hydroxy-2-tetrahydrofurfuryl-5,9-dimethyl-6,7-benzomorphan diastereomers. J Med Chem. 1991 Aug;34(8):2438-44. DMS7FC6 RU https://pubmed.ncbi.nlm.nih.gov/1652019 DMS7FC6 DI DMS7FC6 DMS7FC6 DN MR-1029 DMS7FC6 MI TTKWM86 DMS7FC6 MN Opioid receptor mu (MOP) DMS7FC6 MT DTT DMS7FC6 MA Inhibitor DMS7FC6 RN Electrophilic gamma-lactone kappa-opioid receptor probes. Analogues of 2'-hydroxy-2-tetrahydrofurfuryl-5,9-dimethyl-6,7-benzomorphan diastereomers. J Med Chem. 1991 Aug;34(8):2438-44. DMS7FC6 RU https://pubmed.ncbi.nlm.nih.gov/1652019 DM5WMXJ DI DM5WMXJ DM5WMXJ DN MR-1526 DM5WMXJ MI TTQW87Y DM5WMXJ MN Opioid receptor kappa (OPRK1) DM5WMXJ MT DTT DM5WMXJ MA Inhibitor DM5WMXJ RN Electrophilic gamma-lactone kappa-opioid receptor probes. Analogues of 2'-hydroxy-2-tetrahydrofurfuryl-5,9-dimethyl-6,7-benzomorphan diastereomers. J Med Chem. 1991 Aug;34(8):2438-44. DM5WMXJ RU https://pubmed.ncbi.nlm.nih.gov/1652019 DM5WMXJ DI DM5WMXJ DM5WMXJ DN MR-1526 DM5WMXJ MI TTKWM86 DM5WMXJ MN Opioid receptor mu (MOP) DM5WMXJ MT DTT DM5WMXJ MA Inhibitor DM5WMXJ RN Electrophilic gamma-lactone kappa-opioid receptor probes. Analogues of 2'-hydroxy-2-tetrahydrofurfuryl-5,9-dimethyl-6,7-benzomorphan diastereomers. J Med Chem. 1991 Aug;34(8):2438-44. DM5WMXJ RU https://pubmed.ncbi.nlm.nih.gov/1652019 DMM2WG7 DI DMM2WG7 DMM2WG7 DN MR-16089 DMM2WG7 MI TTSZLWK DMM2WG7 MN Aromatase (CYP19A1) DMM2WG7 MT DTT DMM2WG7 MA Inhibitor DMM2WG7 RN Pharmacophore modeling strategies for the development of novel nonsteroidal inhibitors of human aromatase (CYP19). Bioorg Med Chem Lett. 2010 May 15;20(10):3050-64. DMM2WG7 RU https://pubmed.ncbi.nlm.nih.gov/20413308 DMF04AG DI DMF04AG DMF04AG DN MR-2034 DMF04AG MI TTQW87Y DMF04AG MN Opioid receptor kappa (OPRK1) DMF04AG MT DTT DMF04AG MA Inhibitor DMF04AG RN Syntheses and opioid receptor binding properties of carboxamido-substituted opioids. Bioorg Med Chem Lett. 2009 Jan 1;19(1):203-8. DMF04AG RU https://pubmed.ncbi.nlm.nih.gov/19027293 DMF04AG DI DMF04AG DMF04AG DN MR-2034 DMF04AG MI TTKWM86 DMF04AG MN Opioid receptor mu (MOP) DMF04AG MT DTT DMF04AG MA Inhibitor DMF04AG RN Syntheses and opioid receptor binding properties of carboxamido-substituted opioids. Bioorg Med Chem Lett. 2009 Jan 1;19(1):203-8. DMF04AG RU https://pubmed.ncbi.nlm.nih.gov/19027293 DMEBQLK DI DMEBQLK DMEBQLK DN MR-20492 DMEBQLK MI TTSZLWK DMEBQLK MN Aromatase (CYP19A1) DMEBQLK MT DTT DMEBQLK MA Inhibitor DMEBQLK RN Pharmacophore modeling strategies for the development of novel nonsteroidal inhibitors of human aromatase (CYP19). Bioorg Med Chem Lett. 2010 May 15;20(10):3050-64. DMEBQLK RU https://pubmed.ncbi.nlm.nih.gov/20413308 DMC79YF DI DMC79YF DMC79YF DN MR-20494 DMC79YF MI TTSZLWK DMC79YF MN Aromatase (CYP19A1) DMC79YF MT DTT DMC79YF MA Inhibitor DMC79YF RN Pharmacophore modeling strategies for the development of novel nonsteroidal inhibitors of human aromatase (CYP19). Bioorg Med Chem Lett. 2010 May 15;20(10):3050-64. DMC79YF RU https://pubmed.ncbi.nlm.nih.gov/20413308 DMTCG8M DI DMTCG8M DMTCG8M DN MR-20496 DMTCG8M MI TTSZLWK DMTCG8M MN Aromatase (CYP19A1) DMTCG8M MT DTT DMTCG8M MA Inhibitor DMTCG8M RN Design and synthesis of a new type of non steroidal human aromatase inhibitors. Bioorg Med Chem Lett. 1998 May 5;8(9):1041-4. DMTCG8M RU https://pubmed.ncbi.nlm.nih.gov/9871704 DMSR3OI DI DMSR3OI DMSR3OI DN MR-20814 DMSR3OI MI TTSZLWK DMSR3OI MN Aromatase (CYP19A1) DMSR3OI MT DTT DMSR3OI MA Inhibitor DMSR3OI RN Design and synthesis of a new type of non steroidal human aromatase inhibitors. Bioorg Med Chem Lett. 1998 May 5;8(9):1041-4. DMSR3OI RU https://pubmed.ncbi.nlm.nih.gov/9871704 DMIQ8GL DI DMIQ8GL DMIQ8GL DN MR-22388 DMIQ8GL MI TTML2WA DMIQ8GL MN Tubulin (TUB) DMIQ8GL MT DTT DMIQ8GL MA Inhibitor DMIQ8GL RN Design, synthesis, and evaluation of novel thienopyrrolizinones as antitubulin agents. J Med Chem. 2004 Mar 11;47(6):1448-64. DMIQ8GL RU https://pubmed.ncbi.nlm.nih.gov/14998333 DMIQ8GL DI DMIQ8GL DMIQ8GL DN MR-22388 DMIQ8GL MI TTYFKSZ DMIQ8GL MN Tubulin beta (TUBB) DMIQ8GL MT DTT DMIQ8GL MA Inhibitor DMIQ8GL RN Design, synthesis, and evaluation of novel thienopyrrolizinones as antitubulin agents. J Med Chem. 2004 Mar 11;47(6):1448-64. DMIQ8GL RU https://pubmed.ncbi.nlm.nih.gov/14998333 DMXWSIU DI DMXWSIU DMXWSIU DN MR-2266 DMXWSIU MI TTQW87Y DMXWSIU MN Opioid receptor kappa (OPRK1) DMXWSIU MT DTT DMXWSIU MA Inhibitor DMXWSIU RN Electrophilic gamma-lactone kappa-opioid receptor probes. Analogues of 2'-hydroxy-2-tetrahydrofurfuryl-5,9-dimethyl-6,7-benzomorphan diastereomers. J Med Chem. 1991 Aug;34(8):2438-44. DMXWSIU RU https://pubmed.ncbi.nlm.nih.gov/1652019 DMXWSIU DI DMXWSIU DMXWSIU DN MR-2266 DMXWSIU MI TTKWM86 DMXWSIU MN Opioid receptor mu (MOP) DMXWSIU MT DTT DMXWSIU MA Inhibitor DMXWSIU RN Electrophilic gamma-lactone kappa-opioid receptor probes. Analogues of 2'-hydroxy-2-tetrahydrofurfuryl-5,9-dimethyl-6,7-benzomorphan diastereomers. J Med Chem. 1991 Aug;34(8):2438-44. DMXWSIU RU https://pubmed.ncbi.nlm.nih.gov/1652019 DMUK1PA DI DMUK1PA DMUK1PA DN MRE 2029F20 DMUK1PA MI TTK25J1 DMUK1PA MN Adenosine A1 receptor (ADORA1) DMUK1PA MT DTT DMUK1PA MA Antagonist DMUK1PA RN Design, synthesis, and biological evaluation of new 8-heterocyclic xanthine derivatives as highly potent and selective human A2B adenosine receptor antagonists. J Med Chem. 2004 Mar 11;47(6):1434-47. DMUK1PA RU https://pubmed.ncbi.nlm.nih.gov/14998332 DMUK1PA DI DMUK1PA DMUK1PA DN MRE 2029F20 DMUK1PA MI TTNE7KG DMUK1PA MN Adenosine A2b receptor (ADORA2B) DMUK1PA MT DTT DMUK1PA MA Antagonist DMUK1PA RN Design, synthesis, and biological evaluation of new 8-heterocyclic xanthine derivatives as highly potent and selective human A2B adenosine receptor antagonists. J Med Chem. 2004 Mar 11;47(6):1434-47. DMUK1PA RU https://pubmed.ncbi.nlm.nih.gov/14998332 DMUK1PA DI DMUK1PA DMUK1PA DN MRE 2029F20 DMUK1PA MI TTJFY5U DMUK1PA MN Adenosine A3 receptor (ADORA3) DMUK1PA MT DTT DMUK1PA MA Antagonist DMUK1PA RN Design, synthesis, and biological evaluation of new 8-heterocyclic xanthine derivatives as highly potent and selective human A2B adenosine receptor antagonists. J Med Chem. 2004 Mar 11;47(6):1434-47. DMUK1PA RU https://pubmed.ncbi.nlm.nih.gov/14998332 DM72US0 DI DM72US0 DM72US0 DN MRE 3008F20 DM72US0 MI TTK25J1 DM72US0 MN Adenosine A1 receptor (ADORA1) DM72US0 MT DTT DM72US0 MA Antagonist DM72US0 RN Adenosine receptors as therapeutic targets. Nat Rev Drug Discov. 2006 Mar;5(3):247-64. DM72US0 RU https://pubmed.ncbi.nlm.nih.gov/16518376 DM72US0 DI DM72US0 DM72US0 DN MRE 3008F20 DM72US0 MI TTNE7KG DM72US0 MN Adenosine A2b receptor (ADORA2B) DM72US0 MT DTT DM72US0 MA Antagonist DM72US0 RN Adenosine receptors as therapeutic targets. Nat Rev Drug Discov. 2006 Mar;5(3):247-64. DM72US0 RU https://pubmed.ncbi.nlm.nih.gov/16518376 DM72US0 DI DM72US0 DM72US0 DN MRE 3008F20 DM72US0 MI TTJFY5U DM72US0 MN Adenosine A3 receptor (ADORA3) DM72US0 MT DTT DM72US0 MA Agonist DM72US0 RN [(3)H]MRE 3008F20: a novel antagonist radioligand for the pharmacological and biochemical characterization of human A(3) adenosine receptors. Mol Pharmacol. 2000 May;57(5):968-75. DM72US0 RU https://pubmed.ncbi.nlm.nih.gov/10779381 DMMFJA8 DI DMMFJA8 DMMFJA8 DN MRE 3010F20 DMMFJA8 MI TTJFY5U DMMFJA8 MN Adenosine A3 receptor (ADORA3) DMMFJA8 MT DTT DMMFJA8 MA Antagonist DMMFJA8 RN [(3)H]MRE 3008F20: a novel antagonist radioligand for the pharmacological and biochemical characterization of human A(3) adenosine receptors. Mol Pharmacol. 2000 May;57(5):968-75. DMMFJA8 RU https://pubmed.ncbi.nlm.nih.gov/10779381 DM7VQTO DI DM7VQTO DM7VQTO DN MRK016 DM7VQTO MI TTBMV1G DM7VQTO MN GABA(A) receptor alpha-2 (GABRA2) DM7VQTO MT DTT DM7VQTO MA Modulator DM7VQTO RN A randomized clinical trial of MK-0777 for the treatment of cognitive impairments in people with schizophrenia.Biol Psychiatry.2011 Mar 1;69(5):442-9. DM7VQTO RU https://www.ncbi.nlm.nih.gov/pubmed/21145041 DM7VQTO DI DM7VQTO DM7VQTO DN MRK016 DM7VQTO MI TT37EDJ DM7VQTO MN GABA(A) receptor alpha-3 (GABRA3) DM7VQTO MT DTT DM7VQTO MA Modulator DM7VQTO RN A randomized clinical trial of MK-0777 for the treatment of cognitive impairments in people with schizophrenia.Biol Psychiatry.2011 Mar 1;69(5):442-9. DM7VQTO RU https://www.ncbi.nlm.nih.gov/pubmed/21145041 DM7IK68 DI DM7IK68 DM7IK68 DN MRS 2219 DM7IK68 MI TTJW7B3 DM7IK68 MN P2X purinoceptor 1 (P2RX1) DM7IK68 MT DTT DM7IK68 MA Modulator (allosteric modulator) DM7IK68 RN A pyridoxine cyclic phosphate and its 6-azoaryl derivative selectively potentiate and antagonize activation of P2X1 receptors. J Med Chem. 1998 Jun 18;41(13):2201-6. DM7IK68 RU https://pubmed.ncbi.nlm.nih.gov/9632352 DMBXKYR DI DMBXKYR DMBXKYR DN MRS1041 DMBXKYR MI TTK25J1 DMBXKYR MN Adenosine A1 receptor (ADORA1) DMBXKYR MT DTT DMBXKYR MA Antagonist DMBXKYR RN Synthesis and biological activities of flavonoid derivatives as A3 adenosine receptor antagonists. J Med Chem. 1996 Jun 7;39(12):2293-301. DMBXKYR RU https://pubmed.ncbi.nlm.nih.gov/8691424 DMBXKYR DI DMBXKYR DMBXKYR DN MRS1041 DMBXKYR MI TTNE7KG DMBXKYR MN Adenosine A2b receptor (ADORA2B) DMBXKYR MT DTT DMBXKYR MA Antagonist DMBXKYR RN Synthesis and biological activities of flavonoid derivatives as A3 adenosine receptor antagonists. J Med Chem. 1996 Jun 7;39(12):2293-301. DMBXKYR RU https://pubmed.ncbi.nlm.nih.gov/8691424 DMBXKYR DI DMBXKYR DMBXKYR DN MRS1041 DMBXKYR MI TTJFY5U DMBXKYR MN Adenosine A3 receptor (ADORA3) DMBXKYR MT DTT DMBXKYR MA Antagonist DMBXKYR RN Synthesis and biological activities of flavonoid derivatives as A3 adenosine receptor antagonists. J Med Chem. 1996 Jun 7;39(12):2293-301. DMBXKYR RU https://pubmed.ncbi.nlm.nih.gov/8691424 DMVT865 DI DMVT865 DMVT865 DN MRS1042 DMVT865 MI TTK25J1 DMVT865 MN Adenosine A1 receptor (ADORA1) DMVT865 MT DTT DMVT865 MA Antagonist DMVT865 RN Synthesis and biological activities of flavonoid derivatives as A3 adenosine receptor antagonists. J Med Chem. 1996 Jun 7;39(12):2293-301. DMVT865 RU https://pubmed.ncbi.nlm.nih.gov/8691424 DMVT865 DI DMVT865 DMVT865 DN MRS1042 DMVT865 MI TTNE7KG DMVT865 MN Adenosine A2b receptor (ADORA2B) DMVT865 MT DTT DMVT865 MA Antagonist DMVT865 RN Synthesis and biological activities of flavonoid derivatives as A3 adenosine receptor antagonists. J Med Chem. 1996 Jun 7;39(12):2293-301. DMVT865 RU https://pubmed.ncbi.nlm.nih.gov/8691424 DMVT865 DI DMVT865 DMVT865 DN MRS1042 DMVT865 MI TTJFY5U DMVT865 MN Adenosine A3 receptor (ADORA3) DMVT865 MT DTT DMVT865 MA Antagonist DMVT865 RN Synthesis and biological activities of flavonoid derivatives as A3 adenosine receptor antagonists. J Med Chem. 1996 Jun 7;39(12):2293-301. DMVT865 RU https://pubmed.ncbi.nlm.nih.gov/8691424 DM50QBR DI DM50QBR DM50QBR DN MRS1062 DM50QBR MI TTK25J1 DM50QBR MN Adenosine A1 receptor (ADORA1) DM50QBR MT DTT DM50QBR MA Antagonist DM50QBR RN Synthesis and biological activities of flavonoid derivatives as A3 adenosine receptor antagonists. J Med Chem. 1996 Jun 7;39(12):2293-301. DM50QBR RU https://pubmed.ncbi.nlm.nih.gov/8691424 DMYAHU3 DI DMYAHU3 DMYAHU3 DN MRS1065 DMYAHU3 MI TTK25J1 DMYAHU3 MN Adenosine A1 receptor (ADORA1) DMYAHU3 MT DTT DMYAHU3 MA Antagonist DMYAHU3 RN Synthesis and biological activities of flavonoid derivatives as A3 adenosine receptor antagonists. J Med Chem. 1996 Jun 7;39(12):2293-301. DMYAHU3 RU https://pubmed.ncbi.nlm.nih.gov/8691424 DMYAHU3 DI DMYAHU3 DMYAHU3 DN MRS1065 DMYAHU3 MI TTNE7KG DMYAHU3 MN Adenosine A2b receptor (ADORA2B) DMYAHU3 MT DTT DMYAHU3 MA Antagonist DMYAHU3 RN Synthesis and biological activities of flavonoid derivatives as A3 adenosine receptor antagonists. J Med Chem. 1996 Jun 7;39(12):2293-301. DMYAHU3 RU https://pubmed.ncbi.nlm.nih.gov/8691424 DMAEW9M DI DMAEW9M DMAEW9M DN MRS1067 DMAEW9M MI TTJFY5U DMAEW9M MN Adenosine A3 receptor (ADORA3) DMAEW9M MT DTT DMAEW9M MA Antagonist DMAEW9M RN Pharmacological characterization of novel A3 adenosine receptor-selective antagonists. Neuropharmacology. 1997 Sep;36(9):1157-65. DMAEW9M RU https://pubmed.ncbi.nlm.nih.gov/9364471 DMKELWG DI DMKELWG DMKELWG DN MRS1084 DMKELWG MI TTK25J1 DMKELWG MN Adenosine A1 receptor (ADORA1) DMKELWG MT DTT DMKELWG MA Antagonist DMKELWG RN Synthesis and biological activities of flavonoid derivatives as A3 adenosine receptor antagonists. J Med Chem. 1996 Jun 7;39(12):2293-301. DMKELWG RU https://pubmed.ncbi.nlm.nih.gov/8691424 DMKELWG DI DMKELWG DMKELWG DN MRS1084 DMKELWG MI TTNE7KG DMKELWG MN Adenosine A2b receptor (ADORA2B) DMKELWG MT DTT DMKELWG MA Antagonist DMKELWG RN Synthesis and biological activities of flavonoid derivatives as A3 adenosine receptor antagonists. J Med Chem. 1996 Jun 7;39(12):2293-301. DMKELWG RU https://pubmed.ncbi.nlm.nih.gov/8691424 DM1K5E2 DI DM1K5E2 DM1K5E2 DN MRS1086 DM1K5E2 MI TTK25J1 DM1K5E2 MN Adenosine A1 receptor (ADORA1) DM1K5E2 MT DTT DM1K5E2 MA Antagonist DM1K5E2 RN Synthesis and biological activities of flavonoid derivatives as A3 adenosine receptor antagonists. J Med Chem. 1996 Jun 7;39(12):2293-301. DM1K5E2 RU https://pubmed.ncbi.nlm.nih.gov/8691424 DM1K5E2 DI DM1K5E2 DM1K5E2 DN MRS1086 DM1K5E2 MI TTNE7KG DM1K5E2 MN Adenosine A2b receptor (ADORA2B) DM1K5E2 MT DTT DM1K5E2 MA Antagonist DM1K5E2 RN Synthesis and biological activities of flavonoid derivatives as A3 adenosine receptor antagonists. J Med Chem. 1996 Jun 7;39(12):2293-301. DM1K5E2 RU https://pubmed.ncbi.nlm.nih.gov/8691424 DMSKWL7 DI DMSKWL7 DMSKWL7 DN MRS1088 DMSKWL7 MI TTNE7KG DMSKWL7 MN Adenosine A2b receptor (ADORA2B) DMSKWL7 MT DTT DMSKWL7 MA Antagonist DMSKWL7 RN Synthesis and biological activities of flavonoid derivatives as A3 adenosine receptor antagonists. J Med Chem. 1996 Jun 7;39(12):2293-301. DMSKWL7 RU https://pubmed.ncbi.nlm.nih.gov/8691424 DMSKWL7 DI DMSKWL7 DMSKWL7 DN MRS1088 DMSKWL7 MI TTJFY5U DMSKWL7 MN Adenosine A3 receptor (ADORA3) DMSKWL7 MT DTT DMSKWL7 MA Antagonist DMSKWL7 RN Synthesis and biological activities of flavonoid derivatives as A3 adenosine receptor antagonists. J Med Chem. 1996 Jun 7;39(12):2293-301. DMSKWL7 RU https://pubmed.ncbi.nlm.nih.gov/8691424 DM801AO DI DM801AO DM801AO DN MRS1093 DM801AO MI TTK25J1 DM801AO MN Adenosine A1 receptor (ADORA1) DM801AO MT DTT DM801AO MA Antagonist DM801AO RN Synthesis and biological activities of flavonoid derivatives as A3 adenosine receptor antagonists. J Med Chem. 1996 Jun 7;39(12):2293-301. DM801AO RU https://pubmed.ncbi.nlm.nih.gov/8691424 DM801AO DI DM801AO DM801AO DN MRS1093 DM801AO MI TTNE7KG DM801AO MN Adenosine A2b receptor (ADORA2B) DM801AO MT DTT DM801AO MA Antagonist DM801AO RN Synthesis and biological activities of flavonoid derivatives as A3 adenosine receptor antagonists. J Med Chem. 1996 Jun 7;39(12):2293-301. DM801AO RU https://pubmed.ncbi.nlm.nih.gov/8691424 DM801AO DI DM801AO DM801AO DN MRS1093 DM801AO MI TTJFY5U DM801AO MN Adenosine A3 receptor (ADORA3) DM801AO MT DTT DM801AO MA Antagonist DM801AO RN Synthesis and biological activities of flavonoid derivatives as A3 adenosine receptor antagonists. J Med Chem. 1996 Jun 7;39(12):2293-301. DM801AO RU https://pubmed.ncbi.nlm.nih.gov/8691424 DMLOHAZ DI DMLOHAZ DMLOHAZ DN MRS1097 DMLOHAZ MI TTJFY5U DMLOHAZ MN Adenosine A3 receptor (ADORA3) DMLOHAZ MT DTT DMLOHAZ MA Antagonist DMLOHAZ RN Interaction of 1,4-dihydropyridine and pyridine derivatives with adenosine receptors: selectivity for A3 receptors. J Med Chem. 1996 Jul 19;39(15):2980-9. DMLOHAZ RU https://pubmed.ncbi.nlm.nih.gov/8709132 DMY4C0G DI DMY4C0G DMY4C0G DN MRS1132 DMY4C0G MI TTK25J1 DMY4C0G MN Adenosine A1 receptor (ADORA1) DMY4C0G MT DTT DMY4C0G MA Antagonist DMY4C0G RN Synthesis and biological activities of flavonoid derivatives as A3 adenosine receptor antagonists. J Med Chem. 1996 Jun 7;39(12):2293-301. DMY4C0G RU https://pubmed.ncbi.nlm.nih.gov/8691424 DMY4C0G DI DMY4C0G DMY4C0G DN MRS1132 DMY4C0G MI TTNE7KG DMY4C0G MN Adenosine A2b receptor (ADORA2B) DMY4C0G MT DTT DMY4C0G MA Antagonist DMY4C0G RN Synthesis and biological activities of flavonoid derivatives as A3 adenosine receptor antagonists. J Med Chem. 1996 Jun 7;39(12):2293-301. DMY4C0G RU https://pubmed.ncbi.nlm.nih.gov/8691424 DMBXTPU DI DMBXTPU DMBXTPU DN MRS1177 DMBXTPU MI TTJFY5U DMBXTPU MN Adenosine A3 receptor (ADORA3) DMBXTPU MT DTT DMBXTPU MA Antagonist DMBXTPU RN Derivatives of the triazoloquinazoline adenosine antagonist (CGS15943) are selective for the human A3 receptor subtype. J Med Chem. 1996 Oct 11;39(21):4142-8. DMBXTPU RU https://pubmed.ncbi.nlm.nih.gov/8863790 DMGJ0IE DI DMGJ0IE DMGJ0IE DN MRS1186 DMGJ0IE MI TTJFY5U DMGJ0IE MN Adenosine A3 receptor (ADORA3) DMGJ0IE MT DTT DMGJ0IE MA Antagonist DMGJ0IE RN Derivatives of the triazoloquinazoline adenosine antagonist (CGS15943) are selective for the human A3 receptor subtype. J Med Chem. 1996 Oct 11;39(21):4142-8. DMGJ0IE RU https://pubmed.ncbi.nlm.nih.gov/8863790 DM9WX3C DI DM9WX3C DM9WX3C DN MRS1191 DM9WX3C MI TTK25J1 DM9WX3C MN Adenosine A1 receptor (ADORA1) DM9WX3C MT DTT DM9WX3C MA Antagonist DM9WX3C RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 18). DM9WX3C RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=18 DM9WX3C DI DM9WX3C DM9WX3C DN MRS1191 DM9WX3C MI TTNE7KG DM9WX3C MN Adenosine A2b receptor (ADORA2B) DM9WX3C MT DTT DM9WX3C MA Antagonist DM9WX3C RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 20). DM9WX3C RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=20 DM9WX3C DI DM9WX3C DM9WX3C DN MRS1191 DM9WX3C MI TTJFY5U DM9WX3C MN Adenosine A3 receptor (ADORA3) DM9WX3C MT DTT DM9WX3C MA Antagonist DM9WX3C RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 21). DM9WX3C RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=21 DMT6JH9 DI DMT6JH9 DMT6JH9 DN MRS-1220 DMT6JH9 MI TTJFY5U DMT6JH9 MN Adenosine A3 receptor (ADORA3) DMT6JH9 MT DTT DMT6JH9 MA Antagonist DMT6JH9 RN A(3) adenosine receptor activation attenuates neutrophil function and neutrophil-mediated reperfusion injury. Am J Physiol. 1999 Nov;277(5 Pt 2):H1895-905. DMT6JH9 RU https://pubmed.ncbi.nlm.nih.gov/10564145 DMLQYN7 DI DMLQYN7 DMLQYN7 DN MRS1476 DMLQYN7 MI TTJFY5U DMLQYN7 MN Adenosine A3 receptor (ADORA3) DMLQYN7 MT DTT DMLQYN7 MA Antagonist DMLQYN7 RN Structure-activity relationships and molecular modeling of 3, 5-diacyl-2,4-dialkylpyridine derivatives as selective A3 adenosine receptor antagonists. J Med Chem. 1998 Aug 13;41(17):3186-201. DMLQYN7 RU https://pubmed.ncbi.nlm.nih.gov/9703464 DMFJHMQ DI DMFJHMQ DMFJHMQ DN MRS1486 DMFJHMQ MI TTJFY5U DMFJHMQ MN Adenosine A3 receptor (ADORA3) DMFJHMQ MT DTT DMFJHMQ MA Antagonist DMFJHMQ RN Structure-activity relationships and molecular modeling of 3, 5-diacyl-2,4-dialkylpyridine derivatives as selective A3 adenosine receptor antagonists. J Med Chem. 1998 Aug 13;41(17):3186-201. DMFJHMQ RU https://pubmed.ncbi.nlm.nih.gov/9703464 DM3Q5NO DI DM3Q5NO DM3Q5NO DN MRS1505 DM3Q5NO MI TTJFY5U DM3Q5NO MN Adenosine A3 receptor (ADORA3) DM3Q5NO MT DTT DM3Q5NO MA Antagonist DM3Q5NO RN Structure-activity relationships and molecular modeling of 3, 5-diacyl-2,4-dialkylpyridine derivatives as selective A3 adenosine receptor antagonists. J Med Chem. 1998 Aug 13;41(17):3186-201. DM3Q5NO RU https://pubmed.ncbi.nlm.nih.gov/9703464 DM4AONZ DI DM4AONZ DM4AONZ DN MRS1523 DM4AONZ MI TTK25J1 DM4AONZ MN Adenosine A1 receptor (ADORA1) DM4AONZ MT DTT DM4AONZ MA Antagonist DM4AONZ RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 18). DM4AONZ RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=18 DM4AONZ DI DM4AONZ DM4AONZ DN MRS1523 DM4AONZ MI TTNE7KG DM4AONZ MN Adenosine A2b receptor (ADORA2B) DM4AONZ MT DTT DM4AONZ MA Antagonist DM4AONZ RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 20). DM4AONZ RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=20 DM4AONZ DI DM4AONZ DM4AONZ DN MRS1523 DM4AONZ MI TTJFY5U DM4AONZ MN Adenosine A3 receptor (ADORA3) DM4AONZ MT DTT DM4AONZ MA Antagonist DM4AONZ RN Structure-activity relationships and molecular modeling of 3, 5-diacyl-2,4-dialkylpyridine derivatives as selective A3 adenosine receptor antagonists. J Med Chem. 1998 Aug 13;41(17):3186-201. DM4AONZ RU https://pubmed.ncbi.nlm.nih.gov/9703464 DM5I7PL DI DM5I7PL DM5I7PL DN MRS1706 DM5I7PL MI TTNE7KG DM5I7PL MN Adenosine A2b receptor (ADORA2B) DM5I7PL MT DTT DM5I7PL MA Antagonist DM5I7PL RN Anilide derivatives of an 8-phenylxanthine carboxylic congener are highly potent and selective antagonists at human A(2B) adenosine receptors. J Med Chem. 2000 Mar 23;43(6):1165-72. DM5I7PL RU https://pubmed.ncbi.nlm.nih.gov/10737749 DMHJ47A DI DMHJ47A DMHJ47A DN MRS-2160 DMHJ47A MI TT1NLOA DMHJ47A MN P2X purinoceptor 4 (P2RX4) DMHJ47A MT DTT DMHJ47A MA Inhibitor DMHJ47A RN Purine and pyrimidine (P2) receptors as drug targets. J Med Chem. 2002 Sep 12;45(19):4057-93. DMHJ47A RU https://pubmed.ncbi.nlm.nih.gov/12213051 DMIVGHB DI DMIVGHB DMIVGHB DN MRS-2179 DMIVGHB MI TTA93TL DMIVGHB MN P2Y purinoceptor 1 (P2RY1) DMIVGHB MT DTT DMIVGHB MA Antagonist DMIVGHB RN The P2Y(1) receptor as a target for new antithrombotic drugs: a review of the P2Y(1) antagonist MRS-2179. Cardiovasc Drug Rev. 2003 Spring;21(1):67-76. DMIVGHB RU https://pubmed.ncbi.nlm.nih.gov/12595918 DM2G5ZE DI DM2G5ZE DM2G5ZE DN MRS2211 DM2G5ZE MI TT1FE3L DM2G5ZE MN P2Y purinoceptor 13 (P2RY13) DM2G5ZE MT DTT DM2G5ZE MA Antagonist DM2G5ZE RN Synthesis of pyridoxal phosphate derivatives with antagonist activity at the P2Y13 receptor. Biochem Pharmacol. 2005 Jul 15;70(2):266-74. DM2G5ZE RU https://pubmed.ncbi.nlm.nih.gov/15913566 DM0QGF3 DI DM0QGF3 DM0QGF3 DN MRS2279 DM0QGF3 MI TTA93TL DM0QGF3 MN P2Y purinoceptor 1 (P2RY1) DM0QGF3 MT DTT DM0QGF3 MA Antagonist DM0QGF3 RN Quantitation of the P2Y(1) receptor with a high affinity radiolabeled antagonist. Mol Pharmacol. 2002 Nov;62(5):1249-57. DM0QGF3 RU https://pubmed.ncbi.nlm.nih.gov/12391289 DMZ6EGA DI DMZ6EGA DMZ6EGA DN MRS2298 DMZ6EGA MI TTA93TL DMZ6EGA MN P2Y purinoceptor 1 (P2RY1) DMZ6EGA MT DTT DMZ6EGA MA Antagonist DMZ6EGA RN Antiaggregatory activity in human platelets of potent antagonists of the P2Y 1 receptor. Biochem Pharmacol. 2004 Nov 15;68(10):1995-2002. DMZ6EGA RU https://pubmed.ncbi.nlm.nih.gov/15476670 DM0CS3V DI DM0CS3V DM0CS3V DN MRS2365 DM0CS3V MI TTA93TL DM0CS3V MN P2Y purinoceptor 1 (P2RY1) DM0CS3V MT DTT DM0CS3V MA Agonist DM0CS3V RN Induction of novel agonist selectivity for the ADP-activated P2Y1 receptor versus the ADP-activated P2Y12 and P2Y13 receptors by conformational con... J Pharmacol Exp Ther. 2004 Dec;311(3):1038-43. DM0CS3V RU https://pubmed.ncbi.nlm.nih.gov/15345752 DM0CAKS DI DM0CAKS DM0CAKS DN MRS2496 DM0CAKS MI TTA93TL DM0CAKS MN P2Y purinoceptor 1 (P2RY1) DM0CAKS MT DTT DM0CAKS MA Antagonist DM0CAKS RN Antiaggregatory activity in human platelets of potent antagonists of the P2Y 1 receptor. Biochem Pharmacol. 2004 Nov 15;68(10):1995-2002. DM0CAKS RU https://pubmed.ncbi.nlm.nih.gov/15476670 DMNGTOY DI DMNGTOY DMNGTOY DN MRS2500 DMNGTOY MI TTA93TL DMNGTOY MN P2Y purinoceptor 1 (P2RY1) DMNGTOY MT DTT DMNGTOY MA Antagonist DMNGTOY RN 2-Substitution of adenine nucleotide analogues containing a bicyclo[3.1.0]hexane ring system locked in a northern conformation: enhanced potency as P2Y1 receptor antagonists. J Med Chem. 2003 Nov 6;46(23):4974-87. DMNGTOY RU https://pubmed.ncbi.nlm.nih.gov/14584948 DMUJEA9 DI DMUJEA9 DMUJEA9 DN MRS2567 DMUJEA9 MI TTNVSKA DMUJEA9 MN P2Y purinoceptor 6 (P2RY6) DMUJEA9 MT DTT DMUJEA9 MA Antagonist DMUJEA9 RN Diisothiocyanate derivatives as potent, insurmountable antagonists of P2Y6 nucleotide receptors. Biochem Pharmacol. 2004 May 1;67(9):1763-70. DMUJEA9 RU https://pubmed.ncbi.nlm.nih.gov/15081875 DMKMPS6 DI DMKMPS6 DMKMPS6 DN MRS2578 DMKMPS6 MI TTNVSKA DMKMPS6 MN P2Y purinoceptor 6 (P2RY6) DMKMPS6 MT DTT DMKMPS6 MA Antagonist DMKMPS6 RN Diisothiocyanate derivatives as potent, insurmountable antagonists of P2Y6 nucleotide receptors. Biochem Pharmacol. 2004 May 1;67(9):1763-70. DMKMPS6 RU https://pubmed.ncbi.nlm.nih.gov/15081875 DMNGC79 DI DMNGC79 DMNGC79 DN MRS2603 DMNGC79 MI TT1FE3L DMNGC79 MN P2Y purinoceptor 13 (P2RY13) DMNGC79 MT DTT DMNGC79 MA Antagonist DMNGC79 RN Synthesis of pyridoxal phosphate derivatives with antagonist activity at the P2Y13 receptor. Biochem Pharmacol. 2005 Jul 15;70(2):266-74. DMNGC79 RU https://pubmed.ncbi.nlm.nih.gov/15913566 DMNS3RT DI DMNS3RT DMNS3RT DN MRS2690 DMNS3RT MI TT72OKI DMNS3RT MN P2Y purinoceptor 14 (P2RY14) DMNS3RT MT DTT DMNS3RT MA Agonist DMNS3RT RN The role of P2Y(14) and other P2Y receptors in degranulation of human LAD2 mast cells. Purinergic Signal. 2013 Mar;9(1):31-40. DMNS3RT RU https://pubmed.ncbi.nlm.nih.gov/22825617 DM2L3CJ DI DM2L3CJ DM2L3CJ DN MRS2693 DM2L3CJ MI TTNVSKA DM2L3CJ MN P2Y purinoceptor 6 (P2RY6) DM2L3CJ MT DTT DM2L3CJ MA Agonist DM2L3CJ RN Structure-activity relationships of uridine 5'-diphosphate analogues at the human P2Y6 receptor. J Med Chem. 2006 Sep 7;49(18):5532-43. DM2L3CJ RU https://pubmed.ncbi.nlm.nih.gov/16942026 DM7EZBU DI DM7EZBU DM7EZBU DN MRS2698 DM7EZBU MI TTOZHQC DM7EZBU MN P2Y purinoceptor 2 (P2RY2) DM7EZBU MT DTT DM7EZBU MA Agonist DM7EZBU RN Molecular modeling of the human P2Y2 receptor and design of a selective agonist, 2'-amino-2'-deoxy-2-thiouridine 5'-triphosphate. J Med Chem. 2007 Mar 22;50(6):1166-76. DM7EZBU RU https://pubmed.ncbi.nlm.nih.gov/17302398 DMO5J39 DI DMO5J39 DMO5J39 DN MRS2768 DMO5J39 MI TTOZHQC DMO5J39 MN P2Y purinoceptor 2 (P2RY2) DMO5J39 MT DTT DMO5J39 MA Agonist DMO5J39 RN Synthesis and potency of novel uracil nucleotides and derivatives as P2Y2 and P2Y6 receptor agonists. Bioorg Med Chem. 2008 Jun 15;16(12):6319-32. DMO5J39 RU https://pubmed.ncbi.nlm.nih.gov/18514530 DMZSO4R DI DMZSO4R DMZSO4R DN MRS2782 DMZSO4R MI TTNVSKA DMZSO4R MN P2Y purinoceptor 6 (P2RY6) DMZSO4R MT DTT DMZSO4R MA Agonist DMZSO4R RN Synthesis and potency of novel uracil nucleotides and derivatives as P2Y2 and P2Y6 receptor agonists. Bioorg Med Chem. 2008 Jun 15;16(12):6319-32. DMZSO4R RU https://pubmed.ncbi.nlm.nih.gov/18514530 DMWKZCY DI DMWKZCY DMWKZCY DN MRS2802 DMWKZCY MI TT72OKI DMWKZCY MN P2Y purinoceptor 14 (P2RY14) DMWKZCY MT DTT DMWKZCY MA Agonist DMWKZCY RN Human P2Y(14) receptor agonists: truncation of the hexose moiety of uridine-5'-diphosphoglucose and its replacement with alkyl and aryl groups. J Med Chem. 2010 Jan 14;53(1):471-80. DMWKZCY RU https://pubmed.ncbi.nlm.nih.gov/19902968 DMGCPHO DI DMGCPHO DMGCPHO DN MRS2905 DMGCPHO MI TT72OKI DMGCPHO MN P2Y purinoceptor 14 (P2RY14) DMGCPHO MT DTT DMGCPHO MA Agonist DMGCPHO RN Pharmacochemistry of the platelet purinergic receptors. Purinergic Signal. 2011 Sep;7(3):305-24. DMGCPHO RU https://pubmed.ncbi.nlm.nih.gov/21484092 DMB2A7Q DI DMB2A7Q DMB2A7Q DN MRS2927 DMB2A7Q MI TT24DGP DMB2A7Q MN P2Y purinoceptor 4 (P2RY4) DMB2A7Q MT DTT DMB2A7Q MA Agonist DMB2A7Q RN Pyrimidine nucleotides with 4-alkyloxyimino and terminal tetraphosphate delta-ester modifications as selective agonists of the P2Y(4) receptor. J Med Chem. 2011 Jun 23;54(12):4018-33. DMB2A7Q RU https://pubmed.ncbi.nlm.nih.gov/21528910 DMDSB1F DI DMDSB1F DMDSB1F DN MRS2950 DMDSB1F MI TTA93TL DMDSB1F MN P2Y purinoceptor 1 (P2RY1) DMDSB1F MT DTT DMDSB1F MA Antagonist DMDSB1F RN Virtual screening leads to the discovery of novel non-nucleotide P2Y receptor antagonists. Bioorg Med Chem. 2012 Sep 1;20(17):5254-61. DMDSB1F RU https://pubmed.ncbi.nlm.nih.gov/22831801 DMROQP6 DI DMROQP6 DMROQP6 DN MRS2957 DMROQP6 MI TTNVSKA DMROQP6 MN P2Y purinoceptor 6 (P2RY6) DMROQP6 MT DTT DMROQP6 MA Agonist DMROQP6 RN Pyrimidine ribonucleotides with enhanced selectivity as P2Y(6) receptor agonists: novel 4-alkyloxyimino, (S)-methanocarba, and 5'-triphosphate gamma-ester modifications. J Med Chem. 2010 Jun 10;53(11):4488-501. DMROQP6 RU https://pubmed.ncbi.nlm.nih.gov/20446735 DMWKXGP DI DMWKXGP DMWKXGP DN MRS4062 DMWKXGP MI TT24DGP DMWKXGP MN P2Y purinoceptor 4 (P2RY4) DMWKXGP MT DTT DMWKXGP MA Agonist DMWKXGP RN Pyrimidine nucleotides with 4-alkyloxyimino and terminal tetraphosphate delta-ester modifications as selective agonists of the P2Y(4) receptor. J Med Chem. 2011 Jun 23;54(12):4018-33. DMWKXGP RU https://pubmed.ncbi.nlm.nih.gov/21528910 DM1GUTC DI DM1GUTC DM1GUTC DN MRS5151 DM1GUTC MI TTK25J1 DM1GUTC MN Adenosine A1 receptor (ADORA1) DM1GUTC MT DTT DM1GUTC MA Agonist DM1GUTC RN Design of (N)-methanocarba adenosine 5'-uronamides as species-independent A3 receptor-selective agonists. Bioorg Med Chem Lett. 2008 May 1;18(9):2813-9. DM1GUTC RU https://pubmed.ncbi.nlm.nih.gov/18424135 DM1GUTC DI DM1GUTC DM1GUTC DN MRS5151 DM1GUTC MI TTNE7KG DM1GUTC MN Adenosine A2b receptor (ADORA2B) DM1GUTC MT DTT DM1GUTC MA Agonist DM1GUTC RN Design of (N)-methanocarba adenosine 5'-uronamides as species-independent A3 receptor-selective agonists. Bioorg Med Chem Lett. 2008 May 1;18(9):2813-9. DM1GUTC RU https://pubmed.ncbi.nlm.nih.gov/18424135 DM1GUTC DI DM1GUTC DM1GUTC DN MRS5151 DM1GUTC MI TTJFY5U DM1GUTC MN Adenosine A3 receptor (ADORA3) DM1GUTC MT DTT DM1GUTC MA Agonist DM1GUTC RN Design of (N)-methanocarba adenosine 5'-uronamides as species-independent A3 receptor-selective agonists. Bioorg Med Chem Lett. 2008 May 1;18(9):2813-9. DM1GUTC RU https://pubmed.ncbi.nlm.nih.gov/18424135 DMDF6WG DI DMDF6WG DMDF6WG DN MRS5698 DMDF6WG MI TTJFY5U DMDF6WG MN Adenosine A3 receptor (ADORA3) DMDF6WG MT DTT DMDF6WG MA Agonist DMDF6WG RN Structure-guided design of A(3) adenosine receptor-selective nucleosides: combination of 2-arylethynyl and bicyclo[3.1.0]hexane substitutions. J Med Chem. 2012 May 24;55(10):4847-60. DMDF6WG RU https://pubmed.ncbi.nlm.nih.gov/22559880 DMMN42V DI DMMN42V DMMN42V DN MRS923 DMMN42V MI TTK25J1 DMMN42V MN Adenosine A1 receptor (ADORA1) DMMN42V MT DTT DMMN42V MA Antagonist DMMN42V RN Synthesis and biological activities of flavonoid derivatives as A3 adenosine receptor antagonists. J Med Chem. 1996 Jun 7;39(12):2293-301. DMMN42V RU https://pubmed.ncbi.nlm.nih.gov/8691424 DMMN42V DI DMMN42V DMMN42V DN MRS923 DMMN42V MI TTNE7KG DMMN42V MN Adenosine A2b receptor (ADORA2B) DMMN42V MT DTT DMMN42V MA Antagonist DMMN42V RN Synthesis and biological activities of flavonoid derivatives as A3 adenosine receptor antagonists. J Med Chem. 1996 Jun 7;39(12):2293-301. DMMN42V RU https://pubmed.ncbi.nlm.nih.gov/8691424 DMKJ9WM DI DMKJ9WM DMKJ9WM DN MRS928 DMKJ9WM MI TTK25J1 DMKJ9WM MN Adenosine A1 receptor (ADORA1) DMKJ9WM MT DTT DMKJ9WM MA Antagonist DMKJ9WM RN Synthesis and biological activities of flavonoid derivatives as A3 adenosine receptor antagonists. J Med Chem. 1996 Jun 7;39(12):2293-301. DMKJ9WM RU https://pubmed.ncbi.nlm.nih.gov/8691424 DMKJ9WM DI DMKJ9WM DMKJ9WM DN MRS928 DMKJ9WM MI TTNE7KG DMKJ9WM MN Adenosine A2b receptor (ADORA2B) DMKJ9WM MT DTT DMKJ9WM MA Antagonist DMKJ9WM RN Synthesis and biological activities of flavonoid derivatives as A3 adenosine receptor antagonists. J Med Chem. 1996 Jun 7;39(12):2293-301. DMKJ9WM RU https://pubmed.ncbi.nlm.nih.gov/8691424 DMKJ9WM DI DMKJ9WM DMKJ9WM DN MRS928 DMKJ9WM MI TTJFY5U DMKJ9WM MN Adenosine A3 receptor (ADORA3) DMKJ9WM MT DTT DMKJ9WM MA Antagonist DMKJ9WM RN Synthesis and biological activities of flavonoid derivatives as A3 adenosine receptor antagonists. J Med Chem. 1996 Jun 7;39(12):2293-301. DMKJ9WM RU https://pubmed.ncbi.nlm.nih.gov/8691424 DMYRCHG DI DMYRCHG DMYRCHG DN MRT67307 DMYRCHG MI TTRPDBG DMYRCHG MN Inhibitor of nuclear factor kappa-B kinase (IKK) DMYRCHG MT DTT DMYRCHG MA Inhibitor DMYRCHG RN Novel cross-talk within the IKK family controls innate immunity. Biochem J. 2011 Feb 15;434(1):93-104. DMYRCHG RU https://pubmed.ncbi.nlm.nih.gov/21138416 DMYRCHG DI DMYRCHG DMYRCHG DN MRT67307 DMYRCHG MI TTH5TC2 DMYRCHG MN NF-kappa-B-activating kinase (TBK1) DMYRCHG MT DTT DMYRCHG MA Inhibitor DMYRCHG RN Novel cross-talk within the IKK family controls innate immunity. Biochem J. 2011 Feb 15;434(1):93-104. DMYRCHG RU https://pubmed.ncbi.nlm.nih.gov/21138416 DMTPGQ3 DI DMTPGQ3 DMTPGQ3 DN MS1943 DMTPGQ3 MI TT9MZCQ DMTPGQ3 MN Enhancer of zeste homolog 2 (EZH2) DMTPGQ3 MT DTT DMTPGQ3 MA Degrader DMTPGQ3 RN Epigenetics and beyond: targeting writers of protein lysine methylation to treat disease. Nat Rev Drug Discov. 2021 Apr;20(4):265-286. DMTPGQ3 RU https://pubmed.ncbi.nlm.nih.gov/33469207 DMXC30P DI DMXC30P DMXC30P DN MS417 DMXC30P MI TTRA6BO DMXC30P MN Bromodomain-containing protein 4 (BRD4) DMXC30P MT DTT DMXC30P MA Inhibitor DMXC30P RN Down-regulation of NF- B transcriptional activity in HIV-associated kidney disease by BRD4 inhibition. J Biol Chem. 2012 Aug 17;287(34):28840-51. DMXC30P RU https://pubmed.ncbi.nlm.nih.gov/22645123 DMNBFX0 DI DMNBFX0 DMNBFX0 DN MS436 DMNBFX0 MI TTRA6BO DMNBFX0 MN Bromodomain-containing protein 4 (BRD4) DMNBFX0 MT DTT DMNBFX0 MA Inhibitor DMNBFX0 RN Structure-guided design of potent diazobenzene inhibitors for the BET bromodomains. J Med Chem. 2013 Nov 27;56(22):9251-64. DMNBFX0 RU https://pubmed.ncbi.nlm.nih.gov/24144283 DMBTPDL DI DMBTPDL DMBTPDL DN MS453 DMBTPDL MI TTGC95K DMBTPDL MN SET domain containing 8 (KMT5A) DMBTPDL MT DTT DMBTPDL MA Inhibitor DMBTPDL RN Structure-Based Design of a Covalent Inhibitor of the SET Domain-Containing Protein 8 (SETD8) Lysine Methyltransferase. J Med Chem. 2016 Nov 10;59(21):9881-9889. DMBTPDL RU https://pubmed.ncbi.nlm.nih.gov/27804297 DMS3O9H DI DMS3O9H DMS3O9H DN MSC2032964A DMS3O9H MI TTOQCD8 DMS3O9H MN Apoptosis signal-regulating kinase 1 (MAP3K5) DMS3O9H MT DTT DMS3O9H MA Inhibitor DMS3O9H RN Regulation of the severity of neuroinflammation and demyelination by TLR-ASK1-p38 pathway. EMBO Mol Med. 2010 Dec;2(12):504-15. DMS3O9H RU https://pubmed.ncbi.nlm.nih.gov/21064192 DMU67CE DI DMU67CE DMU67CE DN MSOPPE DMU67CE MI TT0I76D DMU67CE MN Metabotropic glutamate receptor 7 (mGluR7) DMU67CE MT DTT DMU67CE MA Antagonist DMU67CE RN Binding of [3H](2S,1'S,2'S)-2-(9-xanthylmethyl)-2-(2'-carboxycyclopropyl) glycine ([3H]LY341495) to cell membranes expressing recombinant human group III metabotropic glutamate receptor subtypes. Naunyn Schmiedebergs Arch Pharmacol. 2000 Dec;362(6):546-54. DMU67CE RU https://pubmed.ncbi.nlm.nih.gov/11138847 DMUKWJ2 DI DMUKWJ2 DMUKWJ2 DN MST-400 DMUKWJ2 MI TT7ALZG DMUKWJ2 MN Integrin-linked protein kinase 1 (ILK) DMUKWJ2 MT DTT DMUKWJ2 MA Inhibitor DMUKWJ2 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2041). DMUKWJ2 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2041 DM4KM91 DI DM4KM91 DM4KM91 DN MSVIII-19 DM4KM91 MI TT0MYE2 DM4KM91 MN Glutamate receptor ionotropic kainate 1 (GRIK1) DM4KM91 MT DTT DM4KM91 MA Antagonist DM4KM91 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 450). DM4KM91 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=450 DMF9HYI DI DMF9HYI DMF9HYI DN MSX-3 DMF9HYI MI TTM2AOE DMF9HYI MN Adenosine A2a receptor (ADORA2A) DMF9HYI MT DTT DMF9HYI MA Modulator DMF9HYI RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5610). DMF9HYI RU http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=5610 DM7KIVX DI DM7KIVX DM7KIVX DN MT-001 DM7KIVX MI TTPADOQ DM7KIVX MN HMG-CoA reductase (HMGCR) DM7KIVX MT DTT DM7KIVX MA Modulator DM7KIVX RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 639). DM7KIVX RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=639 DMDK6BP DI DMDK6BP DMDK6BP DN MT-061 DMDK6BP MI TT7AOUD DMDK6BP MN Fatty acid synthase (FASN) DMDK6BP MT DTT DMDK6BP MA Inhibitor DMDK6BP RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2608). DMDK6BP RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2608 DM5PD0G DI DM5PD0G DM5PD0G DN MT-062 DM5PD0G MI TTGKNB4 DM5PD0G MN Epidermal growth factor receptor (EGFR) DM5PD0G MT DTT DM5PD0G MA Inhibitor DM5PD0G RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1797). DM5PD0G RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1797 DMKT1DA DI DMKT1DA DMKT1DA DN MT-II DMKT1DA MI TTEOSZT DMKT1DA MN Melanocortin receptor (MCR) DMKT1DA MT DTT DMKT1DA MA Inhibitor DMKT1DA RN Substitution of arginine with proline and proline derivatives in melanocyte-stimulating hormones leads to selectivity for human melanocortin 4 rece... J Med Chem. 2009 Jun 25;52(12):3627-35. DMKT1DA RU https://pubmed.ncbi.nlm.nih.gov/19473029 DMKT1DA DI DMKT1DA DMKT1DA DN MT-II DMKT1DA MI TT0MV2T DMKT1DA MN Melanocortin receptor 1 (MC1R) DMKT1DA MT DTT DMKT1DA MA Agonist DMKT1DA RN Design of potent linear alpha-melanotropin 4-10 analogues modified in positions 5 and 10. J Med Chem. 1989 Jan;32(1):174-9. DMKT1DA RU https://pubmed.ncbi.nlm.nih.gov/2535874 DMKT1DA DI DMKT1DA DMKT1DA DN MT-II DMKT1DA MI TTNI91K DMKT1DA MN Melanocortin receptor 3 (MC3R) DMKT1DA MT DTT DMKT1DA MA Agonist DMKT1DA RN Characterization of melanocortin receptor ligands on cloned brain melanocortin receptors and on grooming behavior in the rat. Eur J Pharmacol. 1999 Aug 13;378(3):249-58. DMKT1DA RU https://pubmed.ncbi.nlm.nih.gov/10493100 DMKT1DA DI DMKT1DA DMKT1DA DN MT-II DMKT1DA MI TTD0CIQ DMKT1DA MN Melanocortin receptor 4 (MC4R) DMKT1DA MT DTT DMKT1DA MA Agonist DMKT1DA RN Molecular determinants of ligand binding to the human melanocortin-4 receptor. Biochemistry. 2000 Dec 5;39(48):14900-11. DMKT1DA RU https://pubmed.ncbi.nlm.nih.gov/11101306 DMKT1DA DI DMKT1DA DMKT1DA DN MT-II DMKT1DA MI TT6QAJ3 DMKT1DA MN Melanocortin receptor 5 (MC5R) DMKT1DA MT DTT DMKT1DA MA Agonist DMKT1DA RN The role of melanocortins in body weight regulation: opportunities for the treatment of obesity. Eur J Pharmacol. 2002 Apr 12;440(2-3):141-57. DMKT1DA RU https://pubmed.ncbi.nlm.nih.gov/12007532 DMK2FOX DI DMK2FOX DMK2FOX DN MT-Immucillin-H DMK2FOX MI TTMCF1Y DMK2FOX MN Purine nucleoside phosphorylase (PNP) DMK2FOX MT DTT DMK2FOX MA Inhibitor DMK2FOX RN Plasmodium falciparum purine nucleoside phosphorylase: crystal structures, immucillin inhibitors, and dual catalytic function. J Biol Chem. 2004 Apr 30;279(18):18103-6. DMK2FOX RU https://pubmed.ncbi.nlm.nih.gov/14982926 DMXPIKT DI DMXPIKT DMXPIKT DN M-tolyl 10H-phenothiazine-10-carboxylate DMXPIKT MI TTEB0GD DMXPIKT MN Cholinesterase (BCHE) DMXPIKT MT DTT DMXPIKT MA Inhibitor DMXPIKT RN Carbamates with differential mechanism of inhibition toward acetylcholinesterase and butyrylcholinesterase. J Med Chem. 2008 Jul 24;51(14):4200-12. DMXPIKT RU https://pubmed.ncbi.nlm.nih.gov/18570368 DM8KPWM DI DM8KPWM DM8KPWM DN MTSEA DM8KPWM MI TTELV3W DM8KPWM MN Transformation-sensitive protein p120 (TRPA1) DM8KPWM MT DTT DM8KPWM MA Activator DM8KPWM RN Noxious compounds activate TRPA1 ion channels through covalent modification of cysteines. Nature. 2007 Feb 1;445(7127):541-5. DM8KPWM RU https://pubmed.ncbi.nlm.nih.gov/17237762 DM16F75 DI DM16F75 DM16F75 DN MUG trihydrate DM16F75 MI DE5Z9QK DM16F75 MN Beta-glucuronidase (uidA) DM16F75 MT DME DM16F75 MA Metabolism DM16F75 RN Three structurally and functionally distinct beta-glucuronidases from the human gut microbe Bacteroides uniformis. J Biol Chem. 2018 Nov 30;293(48):18559-18573. DM16F75 RU https://pubmed.ncbi.nlm.nih.gov/30301767 DM16F75 DI DM16F75 DM16F75 DN MUG trihydrate DM16F75 MI DELQJ5O DM16F75 MN Beta-glucuronidase (uidA) DM16F75 MT DME DM16F75 MA Metabolism DM16F75 RN Three structurally and functionally distinct beta-glucuronidases from the human gut microbe Bacteroides uniformis. J Biol Chem. 2018 Nov 30;293(48):18559-18573. DM16F75 RU https://pubmed.ncbi.nlm.nih.gov/30301767 DMYV49C DI DMYV49C DMYV49C DN Mulberrofuran C DMYV49C MI TTELIN2 DMYV49C MN PTPN1 messenger RNA (PTPN1 mRNA) DMYV49C MT DTT DMYV49C MA Inhibitor DMYV49C RN Protein tyrosine phosphatase 1B inhibitors from Morus root bark. Bioorg Med Chem Lett. 2006 Mar 1;16(5):1426-9. DMYV49C RU https://pubmed.ncbi.nlm.nih.gov/16356713 DMMKH72 DI DMMKH72 DMMKH72 DN Mulberrofuran D DMMKH72 MI TTELIN2 DMMKH72 MN PTPN1 messenger RNA (PTPN1 mRNA) DMMKH72 MT DTT DMMKH72 MA Inhibitor DMMKH72 RN Protein tyrosine phosphatase 1B inhibitors isolated from Morus bombycis. Bioorg Med Chem Lett. 2009 Dec 1;19(23):6759-61. DMMKH72 RU https://pubmed.ncbi.nlm.nih.gov/19846295 DMTV9P3 DI DMTV9P3 DMTV9P3 DN Mulberrofuran W DMTV9P3 MI TTELIN2 DMTV9P3 MN PTPN1 messenger RNA (PTPN1 mRNA) DMTV9P3 MT DTT DMTV9P3 MA Inhibitor DMTV9P3 RN Protein tyrosine phosphatase 1B inhibitors isolated from Morus bombycis. Bioorg Med Chem Lett. 2009 Dec 1;19(23):6759-61. DMTV9P3 RU https://pubmed.ncbi.nlm.nih.gov/19846295 DMW2Z4I DI DMW2Z4I DMW2Z4I DN Multiform PI3K inhibitors DMW2Z4I MI TTHBTOP DMW2Z4I MN PI3-kinase gamma (PIK3CG) DMW2Z4I MT DTT DMW2Z4I MA Inhibitor DMW2Z4I RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2155). DMW2Z4I RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2155 DM6SYMH DI DM6SYMH DM6SYMH DN Mumbaistatin DM6SYMH MI TT1KPBZ DM6SYMH MN Glucose-6-phosphate translocase (SLC37A4) DM6SYMH MT DTT DM6SYMH MA Inhibitor DM6SYMH RN Studies toward the total synthesis of mumbaistatin, a highly potent glucose-6-phosphate translocase inhibitor. Synthesis of a mumbaistatin analogue. J Org Chem. 2002 Dec 27;67(26):9248-56. DM6SYMH RU https://pubmed.ncbi.nlm.nih.gov/12492326 DM4FR71 DI DM4FR71 DM4FR71 DN muramyl dipeptide DM4FR71 MI TTQX29T DM4FR71 MN NLR pyrin domain containing 1 (NLRP1) DM4FR71 MT DTT DM4FR71 MA Agonist DM4FR71 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1768). DM4FR71 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1768 DM4FR71 DI DM4FR71 DM4FR71 DN muramyl dipeptide DM4FR71 MI TTYPUHA DM4FR71 MN Pattern recognition receptor NOD2 (NOD2) DM4FR71 MT DTT DM4FR71 MA Agonist DM4FR71 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1763). DM4FR71 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1763 DMNDUJ5 DI DMNDUJ5 DMNDUJ5 DN Muscarine DMNDUJ5 MI TTH18TF DMNDUJ5 MN Muscarinic acetylcholine receptor M5 (CHRM5) DMNDUJ5 MT DTT DMNDUJ5 MA Agonist DMNDUJ5 RN The effects of the antagonists of muscarinic acetylcholine receptor subtypes in rat brain on urinary bladder contraction. Nippon Hinyokika Gakkai Zasshi. 2002 Mar;93(3):427-34. DMNDUJ5 RU https://pubmed.ncbi.nlm.nih.gov/11968796 DMNTF2O DI DMNTF2O DMNTF2O DN Muscimol DMNTF2O MI TTNJYV2 DMNTF2O MN Gamma-aminobutyric acid receptor (GAR) DMNTF2O MT DTT DMNTF2O MA Agonist DMNTF2O RN THIP treatment of Huntington's disease. Neurology. 1983 May;33(5):637-9. DMNTF2O RU https://pubmed.ncbi.nlm.nih.gov/6221200 DMNTF2O DI DMNTF2O DMNTF2O DN Muscimol DMNTF2O MI TTAN6JD DMNTF2O MN Glutamate receptor AMPA (GRIA) DMNTF2O MT DTT DMNTF2O MA Agonist DMNTF2O RN GABA(A) receptor ligands and their therapeutic potentials. Curr Top Med Chem. 2002 Aug;2(8):817-32. DMNTF2O RU https://pubmed.ncbi.nlm.nih.gov/12171573 DMAY50R DI DMAY50R DMAY50R DN Mutated growth hormone DMAY50R MI TTG4R8V DMAY50R MN Growth hormone-releasing hormone receptor (GHRHR) DMAY50R MT DTT DMAY50R MA Agonist DMAY50R RN Treatment strategies for acromegaly. Expert Opin Emerg Drugs. 2005 Nov;10(4):875-90. DMAY50R RU https://pubmed.ncbi.nlm.nih.gov/16262568 DMU65NK DI DMU65NK DMU65NK DN Mycophenolic acid DMU65NK MI TTYJOLE DMU65NK MN MERS-CoV papain-like proteinase (PL-PRO) DMU65NK MT DTT DMU65NK MA Inhibitor DMU65NK RN SARS and MERS: recent insights into emerging coronaviruses. Nat Rev Microbiol. 2016 Aug;14(8):523-34. DMU65NK RU https://pubmed.ncbi.nlm.nih.gov/27344959 DMUQP3J DI DMUQP3J DMUQP3J DN Mycophenolic bis(sulfonamide) DMUQP3J MI TTZFTY4 DMUQP3J MN Amidophosphoribosyltransferase (PPAT) DMUQP3J MT DTT DMUQP3J MA Inhibitor DMUQP3J RN Bis(sulfonamide) isosters of mycophenolic adenine dinucleotide analogues: inhibition of inosine monophosphate dehydrogenase. Bioorg Med Chem. 2008 Aug 1;16(15):7462-9. DMUQP3J RU https://pubmed.ncbi.nlm.nih.gov/18583139 DMUQP3J DI DMUQP3J DMUQP3J DN Mycophenolic bis(sulfonamide) DMUQP3J MI TTTB4UP DMUQP3J MN Inosine-5'-monophosphate dehydrogenase 2 (IMPDH2) DMUQP3J MT DTT DMUQP3J MA Inhibitor DMUQP3J RN Bis(sulfonamide) isosters of mycophenolic adenine dinucleotide analogues: inhibition of inosine monophosphate dehydrogenase. Bioorg Med Chem. 2008 Aug 1;16(15):7462-9. DMUQP3J RU https://pubmed.ncbi.nlm.nih.gov/18583139 DM4YRAH DI DM4YRAH DM4YRAH DN Mycophenolic hydroxamic acid DM4YRAH MI TTZFTY4 DM4YRAH MN Amidophosphoribosyltransferase (PPAT) DM4YRAH MT DTT DM4YRAH MA Inhibitor DM4YRAH RN Structure-activity relationships for inhibition of inosine monophosphate dehydrogenase and differentiation induction of K562 cells among the mycoph... Bioorg Med Chem. 2010 Nov 15;18(22):8106-11. DM4YRAH RU https://pubmed.ncbi.nlm.nih.gov/20934342 DM4YRAH DI DM4YRAH DM4YRAH DN Mycophenolic hydroxamic acid DM4YRAH MI TTTB4UP DM4YRAH MN Inosine-5'-monophosphate dehydrogenase 2 (IMPDH2) DM4YRAH MT DTT DM4YRAH MA Inhibitor DM4YRAH RN Structure-activity relationships for inhibition of inosine monophosphate dehydrogenase and differentiation induction of K562 cells among the mycoph... Bioorg Med Chem. 2010 Nov 15;18(22):8106-11. DM4YRAH RU https://pubmed.ncbi.nlm.nih.gov/20934342 DMX1POR DI DMX1POR DMX1POR DN MYOSEVERIN DMX1POR MI TTML2WA DMX1POR MN Tubulin (TUB) DMX1POR MT DTT DMX1POR MA Inhibitor DMX1POR RN Synthesis and biological evaluation of myoseverin derivatives: microtubule assembly inhibitors. J Med Chem. 2001 Dec 20;44(26):4497-500. DMX1POR RU https://pubmed.ncbi.nlm.nih.gov/11741468 DMX1POR DI DMX1POR DMX1POR DN MYOSEVERIN DMX1POR MI TTYFKSZ DMX1POR MN Tubulin beta (TUBB) DMX1POR MT DTT DMX1POR MA Inhibitor DMX1POR RN Synthesis and biological evaluation of myoseverin derivatives: microtubule assembly inhibitors. J Med Chem. 2001 Dec 20;44(26):4497-500. DMX1POR RU https://pubmed.ncbi.nlm.nih.gov/11741468 DMTV4L0 DI DMTV4L0 DMTV4L0 DN Myricetin DMTV4L0 MI TTHBTOP DMTV4L0 MN PI3-kinase gamma (PIK3CG) DMTV4L0 MT DTT DMTV4L0 MA Inhibitor DMTV4L0 RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMTV4L0 RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMVXW4L DI DMVXW4L DMVXW4L DN MYRIOCIN DMVXW4L MI TTWTSCV DMVXW4L MN RAC-alpha serine/threonine-protein kinase (AKT1) DMVXW4L MT DTT DMVXW4L MA Inhibitor DMVXW4L RN Raft nanodomains contribute to Akt/PKB plasma membrane recruitment and activation. Nat Chem Biol. 2008 Sep;4(9):538-47. DMVXW4L RU https://pubmed.ncbi.nlm.nih.gov/18641634 DMVMHTC DI DMVMHTC DMVMHTC DN Myrisglycerol-phosphate DMVMHTC MI DER5U19 DMVMHTC MN Bifunctional epoxide hydrolase 2 (EPHX2) DMVMHTC MT DME DMVMHTC MA Metabolism DMVMHTC RN Role of soluble epoxide hydrolase phosphatase activity in the metabolism of lysophosphatidic acids. Biochem Biophys Res Commun. 2012 Mar 23;419(4):796-800. DMVMHTC RU https://www.ncbi.nlm.nih.gov/pubmed/?term=22387545 DMYX0BL DI DMYX0BL DMYX0BL DN MYRISTIC ACID DMYX0BL MI TTV3NH6 DMYX0BL MN Calmodulin (CALM) DMYX0BL MT DTT DMYX0BL MA Inhibitor DMYX0BL RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DMYX0BL RU https://pubmed.ncbi.nlm.nih.gov/10592235 DMYX0BL DI DMYX0BL DMYX0BL DN MYRISTIC ACID DMYX0BL MI TTMW94E DMYX0BL MN FK506-binding protein 1A (FKBP1A) DMYX0BL MT DTT DMYX0BL MA Inhibitor DMYX0BL RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DMYX0BL RU https://pubmed.ncbi.nlm.nih.gov/10592235 DMYX0BL DI DMYX0BL DMYX0BL DN MYRISTIC ACID DMYX0BL MI TT2F3CD DMYX0BL MN Hepatocyte nuclear factor 4-alpha (HNF4A) DMYX0BL MT DTT DMYX0BL MA Inhibitor DMYX0BL RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DMYX0BL RU https://pubmed.ncbi.nlm.nih.gov/10592235 DMYX0BL DI DMYX0BL DMYX0BL DN MYRISTIC ACID DMYX0BL MI TT4NXYM DMYX0BL MN Human immunodeficiency virus Negative factor (HIV nef) DMYX0BL MT DTT DMYX0BL MA Inhibitor DMYX0BL RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DMYX0BL RU https://pubmed.ncbi.nlm.nih.gov/10592235 DMYX0BL DI DMYX0BL DMYX0BL DN MYRISTIC ACID DMYX0BL MI TT8S9AV DMYX0BL MN Lymphocyte antigen 96 (LY96) DMYX0BL MT DTT DMYX0BL MA Inhibitor DMYX0BL RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DMYX0BL RU https://pubmed.ncbi.nlm.nih.gov/10592235 DMYX0BL DI DMYX0BL DMYX0BL DN MYRISTIC ACID DMYX0BL MI TT0OFWN DMYX0BL MN Pseudomonas UDP-3-O-acyl-GlcNAc deacetylase (Pseudo lpxC) DMYX0BL MT DTT DMYX0BL MA Inhibitor DMYX0BL RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DMYX0BL RU https://pubmed.ncbi.nlm.nih.gov/10592235 DMYX0BL DI DMYX0BL DMYX0BL DN MYRISTIC ACID DMYX0BL MI TTDQTEY DMYX0BL MN Recoverin (RCVRN) DMYX0BL MT DTT DMYX0BL MA Inhibitor DMYX0BL RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DMYX0BL RU https://pubmed.ncbi.nlm.nih.gov/10592235 DMYX0BL DI DMYX0BL DMYX0BL DN MYRISTIC ACID DMYX0BL MI TTISGCA DMYX0BL MN Toll-like receptor 4 (TLR4) DMYX0BL MT DTT DMYX0BL MA Inhibitor DMYX0BL RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DMYX0BL RU https://pubmed.ncbi.nlm.nih.gov/10592235 DMYX0BL DI DMYX0BL DMYX0BL DN MYRISTIC ACID DMYX0BL MI TT3PJMV DMYX0BL MN Tyrosine-protein kinase ABL1 (ABL) DMYX0BL MT DTT DMYX0BL MA Inhibitor DMYX0BL RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DMYX0BL RU https://pubmed.ncbi.nlm.nih.gov/10592235 DMYX0BL DI DMYX0BL DMYX0BL DN MYRISTIC ACID DMYX0BL MI TTVBE0F DMYX0BL MN Virus Genome polyprotein (Viru POL) DMYX0BL MT DTT DMYX0BL MA Inhibitor DMYX0BL RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DMYX0BL RU https://pubmed.ncbi.nlm.nih.gov/10592235 DMV7NGS DI DMV7NGS DMV7NGS DN Myristoyl-Coa DMV7NGS MI TTBAF05 DMV7NGS MN Candida Peptide N-myristoyltransferase (Candi NMT1) DMV7NGS MT DTT DMV7NGS MA Inhibitor DMV7NGS RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMV7NGS RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMGJYIZ DI DMGJYIZ DMGJYIZ DN MystiLol DMGJYIZ MI TTMXGCW DMGJYIZ MN Adrenergic receptor beta-3 (ADRB3) DMGJYIZ MT DTT DMGJYIZ MA Blocker DMGJYIZ RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 29). DMGJYIZ RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=29 DM16SVM DI DM16SVM DM16SVM DN Myxopyronin B DM16SVM MI TTS31JH DM16SVM MN Staphylococcus Plastid RNA polymerase beta (Stap-coc rpoB) DM16SVM MT DTT DM16SVM MA Inhibitor DM16SVM RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DM16SVM RU https://pubmed.ncbi.nlm.nih.gov/10592235 DM093GO DI DM093GO DM093GO DN N-((1H-indol-2-yl)methyl)(phenyl)methanamine DM093GO MI TT3WG5C DM093GO MN Monoamine oxidase type A (MAO-A) DM093GO MT DTT DM093GO MA Inhibitor DM093GO RN Synthesis, structure-activity relationships and molecular modeling studies of new indole inhibitors of monoamine oxidases A and B. Bioorg Med Chem. 2008 Nov 15;16(22):9729-40. DM093GO RU https://pubmed.ncbi.nlm.nih.gov/18951803 DMYUAXR DI DMYUAXR DMYUAXR DN N-((1H-indol-2-yl)methyl)-2-phenylethanamine DMYUAXR MI TT3WG5C DMYUAXR MN Monoamine oxidase type A (MAO-A) DMYUAXR MT DTT DMYUAXR MA Inhibitor DMYUAXR RN Synthesis, structure-activity relationships and molecular modeling studies of new indole inhibitors of monoamine oxidases A and B. Bioorg Med Chem. 2008 Nov 15;16(22):9729-40. DMYUAXR RU https://pubmed.ncbi.nlm.nih.gov/18951803 DMBQ5NS DI DMBQ5NS DMBQ5NS DN N-(1-((cyanomethyl)carbamoyl)cyclohexyl)benzamide DMBQ5NS MI TTDZN01 DMBQ5NS MN Cathepsin K (CTSK) DMBQ5NS MT DTT DMBQ5NS MA Inhibitor DMBQ5NS RN Beta-substituted cyclohexanecarboxamide: a nonpeptidic framework for the design of potent inhibitors of cathepsin K. J Med Chem. 2006 Feb 9;49(3):1066-79. DMBQ5NS RU https://pubmed.ncbi.nlm.nih.gov/16451072 DMJWTH9 DI DMJWTH9 DMJWTH9 DN N-(1-(1-phenylethyl)piperidin-4-yl)-1-naphthamide DMJWTH9 MI TTJQOD7 DMJWTH9 MN 5-HT 2A receptor (HTR2A) DMJWTH9 MT DTT DMJWTH9 MA Inhibitor DMJWTH9 RN Synthesis and in vitro binding studies of substituted piperidine naphthamides. Part I: Influence of the substitution on the basic nitrogen and the ... Bioorg Med Chem Lett. 2007 Mar 15;17(6):1565-9. DMJWTH9 RU https://pubmed.ncbi.nlm.nih.gov/17254782 DMMCGL3 DI DMMCGL3 DMMCGL3 DN N-(1-(1-phenylethyl)piperidin-4-yl)-2-naphthamide DMMCGL3 MI TTJQOD7 DMMCGL3 MN 5-HT 2A receptor (HTR2A) DMMCGL3 MT DTT DMMCGL3 MA Inhibitor DMMCGL3 RN Synthesis and in vitro binding studies of substituted piperidine naphthamides. Part I: Influence of the substitution on the basic nitrogen and the ... Bioorg Med Chem Lett. 2007 Mar 15;17(6):1565-9. DMMCGL3 RU https://pubmed.ncbi.nlm.nih.gov/17254782 DMGYLC1 DI DMGYLC1 DMGYLC1 DN N-(1-(3-bromobenzyl)piperidin-4-yl)-1-naphthamide DMGYLC1 MI TTJQOD7 DMGYLC1 MN 5-HT 2A receptor (HTR2A) DMGYLC1 MT DTT DMGYLC1 MA Inhibitor DMGYLC1 RN Synthesis and in vitro binding studies of substituted piperidine naphthamides. Part II: Influence of the substitution on the benzyl moiety on the a... Bioorg Med Chem Lett. 2007 Mar 15;17(6):1570-4. DMGYLC1 RU https://pubmed.ncbi.nlm.nih.gov/17251022 DMRQKYC DI DMRQKYC DMRQKYC DN N-(1-(3-bromobenzyl)piperidin-4-yl)-2-naphthamide DMRQKYC MI TTJQOD7 DMRQKYC MN 5-HT 2A receptor (HTR2A) DMRQKYC MT DTT DMRQKYC MA Inhibitor DMRQKYC RN Synthesis and in vitro binding studies of substituted piperidine naphthamides. Part II: Influence of the substitution on the benzyl moiety on the a... Bioorg Med Chem Lett. 2007 Mar 15;17(6):1570-4. DMRQKYC RU https://pubmed.ncbi.nlm.nih.gov/17251022 DMS9RDW DI DMS9RDW DMS9RDW DN N-(1-(4-bromobenzyl)piperidin-4-yl)-2-naphthamide DMS9RDW MI TTJQOD7 DMS9RDW MN 5-HT 2A receptor (HTR2A) DMS9RDW MT DTT DMS9RDW MA Inhibitor DMS9RDW RN Synthesis and in vitro binding studies of substituted piperidine naphthamides. Part II: Influence of the substitution on the benzyl moiety on the a... Bioorg Med Chem Lett. 2007 Mar 15;17(6):1570-4. DMS9RDW RU https://pubmed.ncbi.nlm.nih.gov/17251022 DMAP4R8 DI DMAP4R8 DMAP4R8 DN N-(1-(4-nitrobenzyl)piperidin-4-yl)-2-naphthamide DMAP4R8 MI TTJQOD7 DMAP4R8 MN 5-HT 2A receptor (HTR2A) DMAP4R8 MT DTT DMAP4R8 MA Inhibitor DMAP4R8 RN Synthesis and in vitro binding studies of substituted piperidine naphthamides. Part II: Influence of the substitution on the benzyl moiety on the a... Bioorg Med Chem Lett. 2007 Mar 15;17(6):1570-4. DMAP4R8 RU https://pubmed.ncbi.nlm.nih.gov/17251022 DMQSLJI DI DMQSLJI DMQSLJI DN N-(1-(4-phenylbutyl)piperidin-4-yl)-1-naphthamide DMQSLJI MI TTJQOD7 DMQSLJI MN 5-HT 2A receptor (HTR2A) DMQSLJI MT DTT DMQSLJI MA Inhibitor DMQSLJI RN Synthesis and in vitro binding studies of substituted piperidine naphthamides. Part I: Influence of the substitution on the basic nitrogen and the ... Bioorg Med Chem Lett. 2007 Mar 15;17(6):1565-9. DMQSLJI RU https://pubmed.ncbi.nlm.nih.gov/17254782 DMZ84JH DI DMZ84JH DMZ84JH DN N-(1-(4-phenylbutyl)piperidin-4-yl)-2-naphthamide DMZ84JH MI TTJQOD7 DMZ84JH MN 5-HT 2A receptor (HTR2A) DMZ84JH MT DTT DMZ84JH MA Inhibitor DMZ84JH RN Synthesis and in vitro binding studies of substituted piperidine naphthamides. Part I: Influence of the substitution on the basic nitrogen and the ... Bioorg Med Chem Lett. 2007 Mar 15;17(6):1565-9. DMZ84JH RU https://pubmed.ncbi.nlm.nih.gov/17254782 DMWP6OZ DI DMWP6OZ DMWP6OZ DN N-(1,3,4-thiadiazol-2-yl)benzamide DMWP6OZ MI TTSJ6Q4 DMWP6OZ MN LOX-5 messenger RNA (ALOX5 mRNA) DMWP6OZ MT DTT DMWP6OZ MA Inhibitor DMWP6OZ RN Identification of natural-product-derived inhibitors of 5-lipoxygenase activity by ligand-based virtual screening. J Med Chem. 2007 May 31;50(11):2640-6. DMWP6OZ RU https://pubmed.ncbi.nlm.nih.gov/17461565 DMDW8VX DI DMDW8VX DMDW8VX DN N-(1,3-diphenyl-1H-pyrazol-5-yl)benzamide DMDW8VX MI TTHS256 DMDW8VX MN Metabotropic glutamate receptor 5 (mGluR5) DMDW8VX MT DTT DMDW8VX MA Inhibitor DMDW8VX RN Substituent effects of N-(1,3-diphenyl-1H-pyrazol-5-yl)benzamides on positive allosteric modulation of the metabotropic glutamate-5 receptor in rat... J Med Chem. 2006 Jun 1;49(11):3332-44. DMDW8VX RU https://pubmed.ncbi.nlm.nih.gov/16722652 DMEDJ7X DI DMEDJ7X DMEDJ7X DN N-(1,4-diphenyl-1H-pyrazol-5-yl)benzamide DMEDJ7X MI TTHS256 DMEDJ7X MN Metabotropic glutamate receptor 5 (mGluR5) DMEDJ7X MT DTT DMEDJ7X MA Inhibitor DMEDJ7X RN Substituent effects of N-(1,3-diphenyl-1H-pyrazol-5-yl)benzamides on positive allosteric modulation of the metabotropic glutamate-5 receptor in rat... J Med Chem. 2006 Jun 1;49(11):3332-44. DMEDJ7X RU https://pubmed.ncbi.nlm.nih.gov/16722652 DMW460V DI DMW460V DMW460V DN N-(14-methylallyl)norgalanthamine DMW460V MI TT1RS9F DMW460V MN Acetylcholinesterase (AChE) DMW460V MT DTT DMW460V MA Inhibitor DMW460V RN N-Alkylated galanthamine derivatives: Potent acetylcholinesterase inhibitors from Leucojum aestivum. Bioorg Med Chem Lett. 2008 Apr 1;18(7):2263-6. DMW460V RU https://pubmed.ncbi.nlm.nih.gov/18356045 DMFRQ2U DI DMFRQ2U DMFRQ2U DN N-(17-Methylmorphinan-3-yl)-N'-phenylurea DMFRQ2U MI TT27RFC DMFRQ2U MN Opioid receptor delta (OPRD1) DMFRQ2U MT DTT DMFRQ2U MA Inhibitor DMFRQ2U RN Synthesis and opioid receptor binding affinities of 2-substituted and 3-aminomorphinans: ligands for mu, kappa, and delta opioid receptors. J Med Chem. 2010 Jan 14;53(1):402-18. DMFRQ2U RU https://pubmed.ncbi.nlm.nih.gov/19928862 DMFRQ2U DI DMFRQ2U DMFRQ2U DN N-(17-Methylmorphinan-3-yl)-N'-phenylurea DMFRQ2U MI TTQW87Y DMFRQ2U MN Opioid receptor kappa (OPRK1) DMFRQ2U MT DTT DMFRQ2U MA Inhibitor DMFRQ2U RN Synthesis and opioid receptor binding affinities of 2-substituted and 3-aminomorphinans: ligands for mu, kappa, and delta opioid receptors. J Med Chem. 2010 Jan 14;53(1):402-18. DMFRQ2U RU https://pubmed.ncbi.nlm.nih.gov/19928862 DMFRQ2U DI DMFRQ2U DMFRQ2U DN N-(17-Methylmorphinan-3-yl)-N'-phenylurea DMFRQ2U MI TTKWM86 DMFRQ2U MN Opioid receptor mu (MOP) DMFRQ2U MT DTT DMFRQ2U MA Inhibitor DMFRQ2U RN Synthesis and opioid receptor binding affinities of 2-substituted and 3-aminomorphinans: ligands for mu, kappa, and delta opioid receptors. J Med Chem. 2010 Jan 14;53(1):402-18. DMFRQ2U RU https://pubmed.ncbi.nlm.nih.gov/19928862 DMD6N8V DI DMD6N8V DMD6N8V DN N-(1-Adamantyl)-N'-(4-Guanidinobenzyl)Urea DMD6N8V MI TTGY7WI DMD6N8V MN Urokinase-type plasminogen activator (PLAU) DMD6N8V MT DTT DMD6N8V MA Inhibitor DMD6N8V RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMD6N8V RU https://pubmed.ncbi.nlm.nih.gov/17139284 DM29QT4 DI DM29QT4 DM29QT4 DN N-(1-adamantyl)-N'-propylsulfamide DM29QT4 MI TT6OEDT DM29QT4 MN Cannabinoid receptor 1 (CB1) DM29QT4 MT DTT DM29QT4 MA Inhibitor DM29QT4 RN Synthesis and pharmacological evaluation of sulfamide-based analogues of anandamide. Eur J Med Chem. 2009 Dec;44(12):4889-95. DM29QT4 RU https://pubmed.ncbi.nlm.nih.gov/19762126 DM3WBZP DI DM3WBZP DM3WBZP DN N-(1-benzofuran-3-ylmethyl)sulfamide DM3WBZP MI TTANPDJ DM3WBZP MN Carbonic anhydrase II (CA-II) DM3WBZP MT DTT DM3WBZP MA Inhibitor DM3WBZP RN Novel, broad-spectrum anticonvulsants containing a sulfamide group: advancement of N-((benzo[b]thien-3-yl)methyl)sulfamide (JNJ-26990990) into huma... J Med Chem. 2009 Dec 10;52(23):7528-36. DM3WBZP RU https://pubmed.ncbi.nlm.nih.gov/19388676 DMP9A7L DI DMP9A7L DMP9A7L DN N-(1-Benzyl-2-oxo-ethyl)-benzamide DMP9A7L MI TTG5QB7 DMP9A7L MN Calpain-2 (CAPN2) DMP9A7L MT DTT DMP9A7L MA Inhibitor DMP9A7L RN Alpha-diketone and alpha-keto ester derivatives of N-protected amino acids and peptides as novel inhibitors of cysteine and serine proteinases. J Med Chem. 1990 Jan;33(1):11-3. DMP9A7L RU https://pubmed.ncbi.nlm.nih.gov/2296008 DM4HB7S DI DM4HB7S DM4HB7S DN N-(1-benzylpiperidin-4-yl)-3,5-dimethoxybenzamide DM4HB7S MI TTX4RTB DM4HB7S MN Melanin-concentrating hormone receptor 1 (MCHR1) DM4HB7S MT DTT DM4HB7S MA Inhibitor DM4HB7S RN Identification of substituted 4-aminopiperidines and 3-aminopyrrolidines as potent MCH-R1 antagonists for the treatment of obesity. Bioorg Med Chem Lett. 2006 Oct 15;16(20):5445-50. DM4HB7S RU https://pubmed.ncbi.nlm.nih.gov/16879961 DMEKSHG DI DMEKSHG DMEKSHG DN N-(1-benzylpiperidin-4-yl)-4-sulfanylbutanamide DMEKSHG MI TT8JRS7 DMEKSHG MN Beta-secretase (BACE) DMEKSHG MT DTT DMEKSHG MA Inhibitor DMEKSHG RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DMEKSHG RU https://pubmed.ncbi.nlm.nih.gov/10592235 DMUQ6P4 DI DMUQ6P4 DMUQ6P4 DN N-(1-benzylpiperidine-4-yl)-2-naphthamide DMUQ6P4 MI TTJQOD7 DMUQ6P4 MN 5-HT 2A receptor (HTR2A) DMUQ6P4 MT DTT DMUQ6P4 MA Inhibitor DMUQ6P4 RN Synthesis and in vitro binding studies of substituted piperidine naphthamides. Part II: Influence of the substitution on the benzyl moiety on the a... Bioorg Med Chem Lett. 2007 Mar 15;17(6):1570-4. DMUQ6P4 RU https://pubmed.ncbi.nlm.nih.gov/17251022 DM054NF DI DM054NF DM054NF DN N-(1H-benzo[d]imidazol-2-yl)-3-cyanobenzamide DM054NF MI TTILUKB DM054NF MN IRAK4 messenger RNA (IRAK4 mRNA) DM054NF MT DTT DM054NF MA Inhibitor DM054NF RN Discovery and initial SAR of inhibitors of interleukin-1 receptor-associated kinase-4. Bioorg Med Chem Lett. 2006 Jun 1;16(11):2842-5. DM054NF RU https://pubmed.ncbi.nlm.nih.gov/16563752 DM0CWPX DI DM0CWPX DM0CWPX DN N-(1H-benzo[d]imidazol-2-yl)-3-nitrobenzamide DM0CWPX MI TTILUKB DM0CWPX MN IRAK4 messenger RNA (IRAK4 mRNA) DM0CWPX MT DTT DM0CWPX MA Inhibitor DM0CWPX RN Discovery and initial SAR of inhibitors of interleukin-1 receptor-associated kinase-4. Bioorg Med Chem Lett. 2006 Jun 1;16(11):2842-5. DM0CWPX RU https://pubmed.ncbi.nlm.nih.gov/16563752 DMIMJNU DI DMIMJNU DMIMJNU DN N-(1H-indazol-5-yl)acetamide DMIMJNU MI TT8NGED DMIMJNU MN Prostaglandin G/H synthase 1 (COX-1) DMIMJNU MT DTT DMIMJNU MA Inhibitor DMIMJNU RN New analgesics synthetically derived from the paracetamol metabolite N-(4-hydroxyphenyl)-(5Z,8Z,11Z,14Z)-icosatetra-5,8,11,14-enamide. J Med Chem. 2008 Dec 25;51(24):7800-5. DMIMJNU RU https://pubmed.ncbi.nlm.nih.gov/19053765 DMIMJNU DI DMIMJNU DMIMJNU DN N-(1H-indazol-5-yl)acetamide DMIMJNU MI TTVKILB DMIMJNU MN Prostaglandin G/H synthase 2 (COX-2) DMIMJNU MT DTT DMIMJNU MA Inhibitor DMIMJNU RN New analgesics synthetically derived from the paracetamol metabolite N-(4-hydroxyphenyl)-(5Z,8Z,11Z,14Z)-icosatetra-5,8,11,14-enamide. J Med Chem. 2008 Dec 25;51(24):7800-5. DMIMJNU RU https://pubmed.ncbi.nlm.nih.gov/19053765 DM63YJV DI DM63YJV DM63YJV DN N-(1H-indazol-5-yl)icosa-5,8,11,14-tetraenamide DM63YJV MI TT6OEDT DM63YJV MN Cannabinoid receptor 1 (CB1) DM63YJV MT DTT DM63YJV MA Inhibitor DM63YJV RN New analgesics synthetically derived from the paracetamol metabolite N-(4-hydroxyphenyl)-(5Z,8Z,11Z,14Z)-icosatetra-5,8,11,14-enamide. J Med Chem. 2008 Dec 25;51(24):7800-5. DM63YJV RU https://pubmed.ncbi.nlm.nih.gov/19053765 DM63YJV DI DM63YJV DM63YJV DN N-(1H-indazol-5-yl)icosa-5,8,11,14-tetraenamide DM63YJV MI TTMSFAW DM63YJV MN Cannabinoid receptor 2 (CB2) DM63YJV MT DTT DM63YJV MA Inhibitor DM63YJV RN New analgesics synthetically derived from the paracetamol metabolite N-(4-hydroxyphenyl)-(5Z,8Z,11Z,14Z)-icosatetra-5,8,11,14-enamide. J Med Chem. 2008 Dec 25;51(24):7800-5. DM63YJV RU https://pubmed.ncbi.nlm.nih.gov/19053765 DMHAGSW DI DMHAGSW DMHAGSW DN N-(1H-Indol-2-ylmethyl)-N-(4-phenylbutyl)amine DMHAGSW MI TT3WG5C DMHAGSW MN Monoamine oxidase type A (MAO-A) DMHAGSW MT DTT DMHAGSW MA Inhibitor DMHAGSW RN Synthesis, structure-activity relationships and molecular modeling studies of new indole inhibitors of monoamine oxidases A and B. Bioorg Med Chem. 2008 Nov 15;16(22):9729-40. DMHAGSW RU https://pubmed.ncbi.nlm.nih.gov/18951803 DMCM51R DI DMCM51R DMCM51R DN N-(1H-Indol-2-ylmethyl)-N-methyl-N-phenylamine DMCM51R MI TT3WG5C DMCM51R MN Monoamine oxidase type A (MAO-A) DMCM51R MT DTT DMCM51R MA Inhibitor DMCM51R RN Synthesis, structure-activity relationships and molecular modeling studies of new indole inhibitors of monoamine oxidases A and B. Bioorg Med Chem. 2008 Nov 15;16(22):9729-40. DMCM51R RU https://pubmed.ncbi.nlm.nih.gov/18951803 DMCM51R DI DMCM51R DMCM51R DN N-(1H-Indol-2-ylmethyl)-N-methyl-N-phenylamine DMCM51R MI TTGP7BY DMCM51R MN Monoamine oxidase type B (MAO-B) DMCM51R MT DTT DMCM51R MA Inhibitor DMCM51R RN Synthesis, structure-activity relationships and molecular modeling studies of new indole inhibitors of monoamine oxidases A and B. Bioorg Med Chem. 2008 Nov 15;16(22):9729-40. DMCM51R RU https://pubmed.ncbi.nlm.nih.gov/18951803 DMXD592 DI DMXD592 DMXD592 DN N-(1H-Indol-2-ylmethyl)-N-phenylamine DMXD592 MI TT3WG5C DMXD592 MN Monoamine oxidase type A (MAO-A) DMXD592 MT DTT DMXD592 MA Inhibitor DMXD592 RN Synthesis, structure-activity relationships and molecular modeling studies of new indole inhibitors of monoamine oxidases A and B. Bioorg Med Chem. 2008 Nov 15;16(22):9729-40. DMXD592 RU https://pubmed.ncbi.nlm.nih.gov/18951803 DMXD592 DI DMXD592 DMXD592 DN N-(1H-Indol-2-ylmethyl)-N-phenylamine DMXD592 MI TTGP7BY DMXD592 MN Monoamine oxidase type B (MAO-B) DMXD592 MT DTT DMXD592 MA Inhibitor DMXD592 RN Synthesis, structure-activity relationships and molecular modeling studies of new indole inhibitors of monoamine oxidases A and B. Bioorg Med Chem. 2008 Nov 15;16(22):9729-40. DMXD592 RU https://pubmed.ncbi.nlm.nih.gov/18951803 DMY3UZH DI DMY3UZH DMY3UZH DN N-(1-Methyl-1H-indol-2-ylmethyl)-N-phenylamine DMY3UZH MI TT3WG5C DMY3UZH MN Monoamine oxidase type A (MAO-A) DMY3UZH MT DTT DMY3UZH MA Inhibitor DMY3UZH RN Synthesis, structure-activity relationships and molecular modeling studies of new indole inhibitors of monoamine oxidases A and B. Bioorg Med Chem. 2008 Nov 15;16(22):9729-40. DMY3UZH RU https://pubmed.ncbi.nlm.nih.gov/18951803 DMI1HBR DI DMI1HBR DMI1HBR DN N-(1-oxobutan-2-yl)-3-(trifluoromethyl)benzamide DMI1HBR MI TTUMQVO DMI1HBR MN Cathepsin S (CTSS) DMI1HBR MT DTT DMI1HBR MA Inhibitor DMI1HBR RN Trifluoromethylphenyl as P2 for ketoamide-based cathepsin S inhibitors. Bioorg Med Chem Lett. 2010 Dec 1;20(23):6890-4. DMI1HBR RU https://pubmed.ncbi.nlm.nih.gov/21030256 DMU9YF6 DI DMU9YF6 DMU9YF6 DN N-(1-phenethylpiperidin-4-yl)-1-naphthamide DMU9YF6 MI TTJQOD7 DMU9YF6 MN 5-HT 2A receptor (HTR2A) DMU9YF6 MT DTT DMU9YF6 MA Inhibitor DMU9YF6 RN Synthesis and in vitro binding studies of substituted piperidine naphthamides. Part I: Influence of the substitution on the basic nitrogen and the ... Bioorg Med Chem Lett. 2007 Mar 15;17(6):1565-9. DMU9YF6 RU https://pubmed.ncbi.nlm.nih.gov/17254782 DM9QA7Z DI DM9QA7Z DM9QA7Z DN N-(1-phenethylpiperidin-4-yl)-2-naphthamide DM9QA7Z MI TTJQOD7 DM9QA7Z MN 5-HT 2A receptor (HTR2A) DM9QA7Z MT DTT DM9QA7Z MA Inhibitor DM9QA7Z RN Synthesis and in vitro binding studies of substituted piperidine naphthamides. Part I: Influence of the substitution on the basic nitrogen and the ... Bioorg Med Chem Lett. 2007 Mar 15;17(6):1565-9. DM9QA7Z RU https://pubmed.ncbi.nlm.nih.gov/17254782 DM6DEZ4 DI DM6DEZ4 DM6DEZ4 DN N-(1'-Phenyl-ethyl) estradiol-16-carboxamide DM6DEZ4 MI TTIWB6L DM6DEZ4 MN Estradiol 17 beta-dehydrogenase 1 (17-beta-HSD1) DM6DEZ4 MT DTT DM6DEZ4 MA Inhibitor DM6DEZ4 RN Modification of estrone at the 6, 16, and 17 positions: novel potent inhibitors of 17beta-hydroxysteroid dehydrogenase type 1. J Med Chem. 2006 Feb 23;49(4):1325-45. DM6DEZ4 RU https://pubmed.ncbi.nlm.nih.gov/16480268 DMSHWYU DI DMSHWYU DMSHWYU DN N-(1-PHENYL-PROPYL)-FORMAMIDE DMSHWYU MI TT5DOVB DMSHWYU MN Cytomegalovirus Protease (CMV UL80) DMSHWYU MT DTT DMSHWYU MA Inhibitor DMSHWYU RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DMSHWYU RU https://pubmed.ncbi.nlm.nih.gov/10592235 DM6NC8G DI DM6NC8G DM6NC8G DN N-(2-(1H-Indol-3-yl)ethyl)biphenyl-4-carboxamide DM6NC8G MI TT0PG8F DM6NC8G MN Cyclin-dependent kinase 4 (CDK4) DM6NC8G MT DTT DM6NC8G MA Inhibitor DM6NC8G RN Design, synthesis and biological evaluation of new tryptamine and tetrahydro-beta-carboline-based selective inhibitors of CDK4. Bioorg Med Chem. 2008 Aug 15;16(16):7728-39. DM6NC8G RU https://pubmed.ncbi.nlm.nih.gov/18650093 DM97Q6T DI DM97Q6T DM97Q6T DN N-(2-(4-chlorobenzyloxy)-5-bromobenzyl)ethanamine DM97Q6T MI TT2CEJG DM97Q6T MN C-C chemokine receptor type 5 (CCR5) DM97Q6T MT DTT DM97Q6T MA Inhibitor DM97Q6T RN CCR5 receptor antagonists: discovery and SAR of novel 4-hydroxypiperidine derivatives. Bioorg Med Chem Lett. 2007 Apr 1;17(7):1883-7. DM97Q6T RU https://pubmed.ncbi.nlm.nih.gov/17314043 DM57GQN DI DM57GQN DM57GQN DN N-(2-(4-hexyl-2-hydroxyphenoxy)phenyl)acetamide DM57GQN MI TTVTX4N DM57GQN MN Bacterial Fatty acid synthetase I (Bact inhA) DM57GQN MT DTT DM57GQN MA Inhibitor DM57GQN RN Synthesis and in vitro antimycobacterial activity of B-ring modified diaryl ether InhA inhibitors. Bioorg Med Chem Lett. 2008 May 15;18(10):3029-33. DM57GQN RU https://pubmed.ncbi.nlm.nih.gov/18457948 DM4V7AS DI DM4V7AS DM4V7AS DN N-(2-(5-methoxybenzofuran-3-yl)ethyl)acetamide DM4V7AS MI TT0WAIE DM4V7AS MN Melatonin receptor type 1A (MTNR1A) DM4V7AS MT DTT DM4V7AS MA Inhibitor DM4V7AS RN Design and synthesis of benzofuranic derivatives as new ligands at the melatonin-binding site MT3. Bioorg Med Chem. 2008 May 1;16(9):4954-62. DM4V7AS RU https://pubmed.ncbi.nlm.nih.gov/18372181 DM4V7AS DI DM4V7AS DM4V7AS DN N-(2-(5-methoxybenzofuran-3-yl)ethyl)acetamide DM4V7AS MI TT32JK8 DM4V7AS MN Melatonin receptor type 1B (MTNR1B) DM4V7AS MT DTT DM4V7AS MA Inhibitor DM4V7AS RN Design and synthesis of benzofuranic derivatives as new ligands at the melatonin-binding site MT3. Bioorg Med Chem. 2008 May 1;16(9):4954-62. DM4V7AS RU https://pubmed.ncbi.nlm.nih.gov/18372181 DMLTROU DI DMLTROU DMLTROU DN N-(2-(furan-2-yl)-3,4'-bipyridin-6-yl)acetamide DMLTROU MI TTK25J1 DMLTROU MN Adenosine A1 receptor (ADORA1) DMLTROU MT DTT DMLTROU MA Inhibitor DMLTROU RN Discovery of N-(5,6-diarylpyridin-2-yl)amide derivatives as potent and selective A(2B) adenosine receptor antagonists. Bioorg Med Chem Lett. 2010 Mar 1;20(5):1697-700. DMLTROU RU https://pubmed.ncbi.nlm.nih.gov/20137946 DMLTROU DI DMLTROU DMLTROU DN N-(2-(furan-2-yl)-3,4'-bipyridin-6-yl)acetamide DMLTROU MI TTM2AOE DMLTROU MN Adenosine A2a receptor (ADORA2A) DMLTROU MT DTT DMLTROU MA Inhibitor DMLTROU RN Discovery of N-(5,6-diarylpyridin-2-yl)amide derivatives as potent and selective A(2B) adenosine receptor antagonists. Bioorg Med Chem Lett. 2010 Mar 1;20(5):1697-700. DMLTROU RU https://pubmed.ncbi.nlm.nih.gov/20137946 DMLTROU DI DMLTROU DMLTROU DN N-(2-(furan-2-yl)-3,4'-bipyridin-6-yl)acetamide DMLTROU MI TTNE7KG DMLTROU MN Adenosine A2b receptor (ADORA2B) DMLTROU MT DTT DMLTROU MA Inhibitor DMLTROU RN Discovery of N-(5,6-diarylpyridin-2-yl)amide derivatives as potent and selective A(2B) adenosine receptor antagonists. Bioorg Med Chem Lett. 2010 Mar 1;20(5):1697-700. DMLTROU RU https://pubmed.ncbi.nlm.nih.gov/20137946 DMLTROU DI DMLTROU DMLTROU DN N-(2-(furan-2-yl)-3,4'-bipyridin-6-yl)acetamide DMLTROU MI TTJFY5U DMLTROU MN Adenosine A3 receptor (ADORA3) DMLTROU MT DTT DMLTROU MA Inhibitor DMLTROU RN Discovery of N-(5,6-diarylpyridin-2-yl)amide derivatives as potent and selective A(2B) adenosine receptor antagonists. Bioorg Med Chem Lett. 2010 Mar 1;20(5):1697-700. DMLTROU RU https://pubmed.ncbi.nlm.nih.gov/20137946 DMWC70I DI DMWC70I DMWC70I DN N-(2,3,4,9-Tetrahydro-1H-carbazol-3-yl)-acetamide DMWC70I MI TT0WAIE DMWC70I MN Melatonin receptor type 1A (MTNR1A) DMWC70I MT DTT DMWC70I MA Inhibitor DMWC70I RN Mapping the melatonin receptor. 2. synthesis and biological activity of indole derived melatonin analogues with restricted conformations of the C-3 amidoethane side chain, Bioorg. Med. Chem. Lett. 4(13):1559-1564 (1994). DMWC70I RU http://www.sciencedirect.com/science/article/pii/S0960894X01805667 DMWC70I DI DMWC70I DMWC70I DN N-(2,3,4,9-Tetrahydro-1H-carbazol-3-yl)-acetamide DMWC70I MI TT32JK8 DMWC70I MN Melatonin receptor type 1B (MTNR1B) DMWC70I MT DTT DMWC70I MA Inhibitor DMWC70I RN Mapping the melatonin receptor. 2. synthesis and biological activity of indole derived melatonin analogues with restricted conformations of the C-3 amidoethane side chain, Bioorg. Med. Chem. Lett. 4(13):1559-1564 (1994). DMWC70I RU http://www.sciencedirect.com/science/article/pii/S0960894X01805667 DMUZL3J DI DMUZL3J DMUZL3J DN N-(2,3-DIFLUORO-BENZYL)-4-SULFAMOYL-BENZAMIDE DMUZL3J MI TTANPDJ DMUZL3J MN Carbonic anhydrase II (CA-II) DMUZL3J MT DTT DMUZL3J MA Inhibitor DMUZL3J RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DMUZL3J RU https://pubmed.ncbi.nlm.nih.gov/10592235 DMTLPDZ DI DMTLPDZ DMTLPDZ DN N-(2,3-dihydro-1H-inden-2-yl)isoquinolin-1-amine DMTLPDZ MI TTVBPDM DMTLPDZ MN Metabotropic glutamate receptor 1 (mGluR1) DMTLPDZ MT DTT DMTLPDZ MA Inhibitor DMTLPDZ RN In vitro and in vivo SAR of pyrido[3,4-d]pyramid-4-ylamine based mGluR1 antagonists. Bioorg Med Chem Lett. 2009 Apr 15;19(8):2190-4. DMTLPDZ RU https://pubmed.ncbi.nlm.nih.gov/19289283 DMJ6LI8 DI DMJ6LI8 DMJ6LI8 DN N-(2,3-dihydro-1H-inden-2-yl)quinazolin-4-amine DMJ6LI8 MI TTVBPDM DMJ6LI8 MN Metabotropic glutamate receptor 1 (mGluR1) DMJ6LI8 MT DTT DMJ6LI8 MA Inhibitor DMJ6LI8 RN In vitro and in vivo SAR of pyrido[3,4-d]pyramid-4-ylamine based mGluR1 antagonists. Bioorg Med Chem Lett. 2009 Apr 15;19(8):2190-4. DMJ6LI8 RU https://pubmed.ncbi.nlm.nih.gov/19289283 DMPL26K DI DMPL26K DMPL26K DN N-(2,3-Dihydro-1H-phenalen-2-yl)-acetamide DMPL26K MI TT0WAIE DMPL26K MN Melatonin receptor type 1A (MTNR1A) DMPL26K MT DTT DMPL26K MA Inhibitor DMPL26K RN Synthesis of 2-amido-2,3-dihydro-1H-phenalene derivatives as new conformationally restricted ligands for melatonin receptors. J Med Chem. 1996 Aug 2;39(16):3089-95. DMPL26K RU https://pubmed.ncbi.nlm.nih.gov/8759629 DM5R3ZG DI DM5R3ZG DM5R3ZG DN N-(2,3-Dimethylphenyl)-N'-hydroxyoctanediamide DM5R3ZG MI TTBH0VX DM5R3ZG MN Histone deacetylase (HDAC) DM5R3ZG MT DTT DM5R3ZG MA Inhibitor DM5R3ZG RN Biological and biophysical properties of the histone deacetylase inhibitor suberoylanilide hydroxamic acid are affected by the presence of short al... J Med Chem. 2010 Mar 11;53(5):1937-50. DM5R3ZG RU https://pubmed.ncbi.nlm.nih.gov/20143840 DM5R3ZG DI DM5R3ZG DM5R3ZG DN N-(2,3-Dimethylphenyl)-N'-hydroxyoctanediamide DM5R3ZG MI TT6R7JZ DM5R3ZG MN Histone deacetylase 1 (HDAC1) DM5R3ZG MT DTT DM5R3ZG MA Inhibitor DM5R3ZG RN Biological and biophysical properties of the histone deacetylase inhibitor suberoylanilide hydroxamic acid are affected by the presence of short al... J Med Chem. 2010 Mar 11;53(5):1937-50. DM5R3ZG RU https://pubmed.ncbi.nlm.nih.gov/20143840 DMHI4Y6 DI DMHI4Y6 DMHI4Y6 DN N-(2,4-Dichloro-benzoyl)-benzenesulfonamide DMHI4Y6 MI TTUTJGQ DMHI4Y6 MN Vascular endothelial growth factor receptor 2 (KDR) DMHI4Y6 MT DTT DMHI4Y6 MA Inhibitor DMHI4Y6 RN Acyl sulfonamide anti-proliferatives: benzene substituent structure-activity relationships for a novel class of antitumor agents. J Med Chem. 2004 Oct 21;47(22):5367-80. DMHI4Y6 RU https://pubmed.ncbi.nlm.nih.gov/15481975 DMHI4Y6 DI DMHI4Y6 DMHI4Y6 DN N-(2,4-Dichloro-benzoyl)-benzenesulfonamide DMHI4Y6 MI TTDCBX5 DMHI4Y6 MN Vascular endothelial growth factor receptor 3 (FLT-4) DMHI4Y6 MT DTT DMHI4Y6 MA Inhibitor DMHI4Y6 RN Acyl sulfonamide anti-proliferatives: benzene substituent structure-activity relationships for a novel class of antitumor agents. J Med Chem. 2004 Oct 21;47(22):5367-80. DMHI4Y6 RU https://pubmed.ncbi.nlm.nih.gov/15481975 DMHI4Y6 DI DMHI4Y6 DMHI4Y6 DN N-(2,4-Dichloro-benzoyl)-benzenesulfonamide DMHI4Y6 MI TT1VAUK DMHI4Y6 MN VEGFR1 messenger RNA (VEGFR1 mRNA) DMHI4Y6 MT DTT DMHI4Y6 MA Inhibitor DMHI4Y6 RN Acyl sulfonamide anti-proliferatives: benzene substituent structure-activity relationships for a novel class of antitumor agents. J Med Chem. 2004 Oct 21;47(22):5367-80. DMHI4Y6 RU https://pubmed.ncbi.nlm.nih.gov/15481975 DM5COQ9 DI DM5COQ9 DM5COQ9 DN N-(2,4-dichlorophenyl)-2-nitrobenzamide DM5COQ9 MI TTVTX4N DM5COQ9 MN Bacterial Fatty acid synthetase I (Bact inhA) DM5COQ9 MT DTT DM5COQ9 MA Inhibitor DM5COQ9 RN Discovery of potential new InhA direct inhibitors based on pharmacophore and 3D-QSAR analysis followed by in silico screening. Eur J Med Chem. 2009 Sep;44(9):3718-30. DM5COQ9 RU https://pubmed.ncbi.nlm.nih.gov/19428156 DMHJOBQ DI DMHJOBQ DMHJOBQ DN N-(2,4-dichlorophenyl)-4-methyl-3-nitrobenzamide DMHJOBQ MI TTVTX4N DMHJOBQ MN Bacterial Fatty acid synthetase I (Bact inhA) DMHJOBQ MT DTT DMHJOBQ MA Inhibitor DMHJOBQ RN Discovery of potential new InhA direct inhibitors based on pharmacophore and 3D-QSAR analysis followed by in silico screening. Eur J Med Chem. 2009 Sep;44(9):3718-30. DMHJOBQ RU https://pubmed.ncbi.nlm.nih.gov/19428156 DMNT3JV DI DMNT3JV DMNT3JV DN N-(2,4-dihydroxybenzyl)-3,4,5-trihydroxybenzamide DMNT3JV MI TTULVH8 DMNT3JV MN Tyrosinase (TYR) DMNT3JV MT DTT DMNT3JV MA Inhibitor DMNT3JV RN N-Benzylbenzamides: a new class of potent tyrosinase inhibitors. Bioorg Med Chem Lett. 2006 May 15;16(10):2682-4. DMNT3JV RU https://pubmed.ncbi.nlm.nih.gov/16513349 DM3IMXF DI DM3IMXF DM3IMXF DN N-(2,4-dihydroxybenzyl)-3,4-dihydroxybenzamide DM3IMXF MI TTULVH8 DM3IMXF MN Tyrosinase (TYR) DM3IMXF MT DTT DM3IMXF MA Inhibitor DM3IMXF RN N-Benzylbenzamides: a new class of potent tyrosinase inhibitors. Bioorg Med Chem Lett. 2006 May 15;16(10):2682-4. DM3IMXF RU https://pubmed.ncbi.nlm.nih.gov/16513349 DM6U8SL DI DM6U8SL DM6U8SL DN N-(2,4-dihydroxybenzyl)-3,5-dihydroxybenzamide DM6U8SL MI TTULVH8 DM6U8SL MN Tyrosinase (TYR) DM6U8SL MT DTT DM6U8SL MA Inhibitor DM6U8SL RN N-Benzylbenzamides: a new class of potent tyrosinase inhibitors. Bioorg Med Chem Lett. 2006 May 15;16(10):2682-4. DM6U8SL RU https://pubmed.ncbi.nlm.nih.gov/16513349 DM3QWZU DI DM3QWZU DM3QWZU DN N-(2,4-dimethoxyphenethyl)docos-13-enamide DM3QWZU MI TT6OEDT DM3QWZU MN Cannabinoid receptor 1 (CB1) DM3QWZU MT DTT DM3QWZU MA Inhibitor DM3QWZU RN New metabolically stable fatty acid amide ligands of cannabinoid receptors: Synthesis and receptor affinity studies. Bioorg Med Chem Lett. 2006 Jan 1;16(1):138-41. DM3QWZU RU https://pubmed.ncbi.nlm.nih.gov/16213718 DMRQSD2 DI DMRQSD2 DMRQSD2 DN N-(2,4-dimethoxyphenethyl)oleamide DMRQSD2 MI TT6OEDT DMRQSD2 MN Cannabinoid receptor 1 (CB1) DMRQSD2 MT DTT DMRQSD2 MA Inhibitor DMRQSD2 RN New metabolically stable fatty acid amide ligands of cannabinoid receptors: Synthesis and receptor affinity studies. Bioorg Med Chem Lett. 2006 Jan 1;16(1):138-41. DMRQSD2 RU https://pubmed.ncbi.nlm.nih.gov/16213718 DME0YBF DI DME0YBF DME0YBF DN N-(2,4-Dimethoxy-phenyl)-3,5-dimethoxy-benzamide DME0YBF MI TTI84H7 DME0YBF MN Cytochrome P450 1B1 (CYP1B1) DME0YBF MT DTT DME0YBF MA Inhibitor DME0YBF RN Design, synthesis, and discovery of novel trans-stilbene analogues as potent and selective human cytochrome P450 1B1 inhibitors. J Med Chem. 2002 Jan 3;45(1):160-4. DME0YBF RU https://pubmed.ncbi.nlm.nih.gov/11754588 DMFZAS9 DI DMFZAS9 DMFZAS9 DN N-(2,4-dimethylphenyl)-2-nitrobenzamide DMFZAS9 MI TTVTX4N DMFZAS9 MN Bacterial Fatty acid synthetase I (Bact inhA) DMFZAS9 MT DTT DMFZAS9 MA Inhibitor DMFZAS9 RN Discovery of potential new InhA direct inhibitors based on pharmacophore and 3D-QSAR analysis followed by in silico screening. Eur J Med Chem. 2009 Sep;44(9):3718-30. DMFZAS9 RU https://pubmed.ncbi.nlm.nih.gov/19428156 DMXA9MR DI DMXA9MR DMXA9MR DN N-(2,4-Dimethylphenyl)-N'-hydroxyoctanediamide DMXA9MR MI TTBH0VX DMXA9MR MN Histone deacetylase (HDAC) DMXA9MR MT DTT DMXA9MR MA Inhibitor DMXA9MR RN Biological and biophysical properties of the histone deacetylase inhibitor suberoylanilide hydroxamic acid are affected by the presence of short al... J Med Chem. 2010 Mar 11;53(5):1937-50. DMXA9MR RU https://pubmed.ncbi.nlm.nih.gov/20143840 DMXA9MR DI DMXA9MR DMXA9MR DN N-(2,4-Dimethylphenyl)-N'-hydroxyoctanediamide DMXA9MR MI TT6R7JZ DMXA9MR MN Histone deacetylase 1 (HDAC1) DMXA9MR MT DTT DMXA9MR MA Inhibitor DMXA9MR RN Biological and biophysical properties of the histone deacetylase inhibitor suberoylanilide hydroxamic acid are affected by the presence of short al... J Med Chem. 2010 Mar 11;53(5):1937-50. DMXA9MR RU https://pubmed.ncbi.nlm.nih.gov/20143840 DMUVSM1 DI DMUVSM1 DMUVSM1 DN N-(2,5-dichlorophenyl)-4-methoxy-3-nitrobenzamide DMUVSM1 MI TTVTX4N DMUVSM1 MN Bacterial Fatty acid synthetase I (Bact inhA) DMUVSM1 MT DTT DMUVSM1 MA Inhibitor DMUVSM1 RN Discovery of potential new InhA direct inhibitors based on pharmacophore and 3D-QSAR analysis followed by in silico screening. Eur J Med Chem. 2009 Sep;44(9):3718-30. DMUVSM1 RU https://pubmed.ncbi.nlm.nih.gov/19428156 DMOL79W DI DMOL79W DMOL79W DN N-(2,5-Dimethylphenyl)-N'-hydroxyoctanediamide DMOL79W MI TTBH0VX DMOL79W MN Histone deacetylase (HDAC) DMOL79W MT DTT DMOL79W MA Inhibitor DMOL79W RN Biological and biophysical properties of the histone deacetylase inhibitor suberoylanilide hydroxamic acid are affected by the presence of short al... J Med Chem. 2010 Mar 11;53(5):1937-50. DMOL79W RU https://pubmed.ncbi.nlm.nih.gov/20143840 DMOL79W DI DMOL79W DMOL79W DN N-(2,5-Dimethylphenyl)-N'-hydroxyoctanediamide DMOL79W MI TT6R7JZ DMOL79W MN Histone deacetylase 1 (HDAC1) DMOL79W MT DTT DMOL79W MA Inhibitor DMOL79W RN Biological and biophysical properties of the histone deacetylase inhibitor suberoylanilide hydroxamic acid are affected by the presence of short al... J Med Chem. 2010 Mar 11;53(5):1937-50. DMOL79W RU https://pubmed.ncbi.nlm.nih.gov/20143840 DM9ATQ6 DI DM9ATQ6 DM9ATQ6 DN N-(2,6-Diflouro-Benzyl)-4-Sulfamoyl-Benzamide DM9ATQ6 MI TTANPDJ DM9ATQ6 MN Carbonic anhydrase II (CA-II) DM9ATQ6 MT DTT DM9ATQ6 MA Inhibitor DM9ATQ6 RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DM9ATQ6 RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMTBAPH DI DMTBAPH DMTBAPH DN N-(2,6-Dimethylphenyl)-N'-hydroxyoctanediamide DMTBAPH MI TTBH0VX DMTBAPH MN Histone deacetylase (HDAC) DMTBAPH MT DTT DMTBAPH MA Inhibitor DMTBAPH RN Biological and biophysical properties of the histone deacetylase inhibitor suberoylanilide hydroxamic acid are affected by the presence of short al... J Med Chem. 2010 Mar 11;53(5):1937-50. DMTBAPH RU https://pubmed.ncbi.nlm.nih.gov/20143840 DMTBAPH DI DMTBAPH DMTBAPH DN N-(2,6-Dimethylphenyl)-N'-hydroxyoctanediamide DMTBAPH MI TT6R7JZ DMTBAPH MN Histone deacetylase 1 (HDAC1) DMTBAPH MT DTT DMTBAPH MA Inhibitor DMTBAPH RN Biological and biophysical properties of the histone deacetylase inhibitor suberoylanilide hydroxamic acid are affected by the presence of short al... J Med Chem. 2010 Mar 11;53(5):1937-50. DMTBAPH RU https://pubmed.ncbi.nlm.nih.gov/20143840 DMK5AU4 DI DMK5AU4 DMK5AU4 DN N-(2,6-diphenylpyrimidin-4-yl)-2-ethylbutyramide DMK5AU4 MI TTK25J1 DMK5AU4 MN Adenosine A1 receptor (ADORA1) DMK5AU4 MT DTT DMK5AU4 MA Inhibitor DMK5AU4 RN 2,4,6-trisubstituted pyrimidines as a new class of selective adenosine A1 receptor antagonists. J Med Chem. 2004 Dec 16;47(26):6529-40. DMK5AU4 RU https://pubmed.ncbi.nlm.nih.gov/15588088 DMK5AU4 DI DMK5AU4 DMK5AU4 DN N-(2,6-diphenylpyrimidin-4-yl)-2-ethylbutyramide DMK5AU4 MI TTM2AOE DMK5AU4 MN Adenosine A2a receptor (ADORA2A) DMK5AU4 MT DTT DMK5AU4 MA Inhibitor DMK5AU4 RN 2,4,6-trisubstituted pyrimidines as a new class of selective adenosine A1 receptor antagonists. J Med Chem. 2004 Dec 16;47(26):6529-40. DMK5AU4 RU https://pubmed.ncbi.nlm.nih.gov/15588088 DM6HGK4 DI DM6HGK4 DM6HGK4 DN N-(2,6-diphenylpyrimidin-4-yl)-3-methylbutyramide DM6HGK4 MI TTK25J1 DM6HGK4 MN Adenosine A1 receptor (ADORA1) DM6HGK4 MT DTT DM6HGK4 MA Inhibitor DM6HGK4 RN 2,4,6-trisubstituted pyrimidines as a new class of selective adenosine A1 receptor antagonists. J Med Chem. 2004 Dec 16;47(26):6529-40. DM6HGK4 RU https://pubmed.ncbi.nlm.nih.gov/15588088 DM6HGK4 DI DM6HGK4 DM6HGK4 DN N-(2,6-diphenylpyrimidin-4-yl)-3-methylbutyramide DM6HGK4 MI TTM2AOE DM6HGK4 MN Adenosine A2a receptor (ADORA2A) DM6HGK4 MT DTT DM6HGK4 MA Inhibitor DM6HGK4 RN 2,4,6-trisubstituted pyrimidines as a new class of selective adenosine A1 receptor antagonists. J Med Chem. 2004 Dec 16;47(26):6529-40. DM6HGK4 RU https://pubmed.ncbi.nlm.nih.gov/15588088 DM6HGK4 DI DM6HGK4 DM6HGK4 DN N-(2,6-diphenylpyrimidin-4-yl)-3-methylbutyramide DM6HGK4 MI TTJFY5U DM6HGK4 MN Adenosine A3 receptor (ADORA3) DM6HGK4 MT DTT DM6HGK4 MA Inhibitor DM6HGK4 RN 2,4,6-trisubstituted pyrimidines as a new class of selective adenosine A1 receptor antagonists. J Med Chem. 2004 Dec 16;47(26):6529-40. DM6HGK4 RU https://pubmed.ncbi.nlm.nih.gov/15588088 DMQ0DMU DI DMQ0DMU DMQ0DMU DN N-(2,6-diphenylpyrimidin-4-yl)acetamide DMQ0DMU MI TTK25J1 DMQ0DMU MN Adenosine A1 receptor (ADORA1) DMQ0DMU MT DTT DMQ0DMU MA Inhibitor DMQ0DMU RN 2,4,6-trisubstituted pyrimidines as a new class of selective adenosine A1 receptor antagonists. J Med Chem. 2004 Dec 16;47(26):6529-40. DMQ0DMU RU https://pubmed.ncbi.nlm.nih.gov/15588088 DMQ0DMU DI DMQ0DMU DMQ0DMU DN N-(2,6-diphenylpyrimidin-4-yl)acetamide DMQ0DMU MI TTM2AOE DMQ0DMU MN Adenosine A2a receptor (ADORA2A) DMQ0DMU MT DTT DMQ0DMU MA Inhibitor DMQ0DMU RN 2,4,6-trisubstituted pyrimidines as a new class of selective adenosine A1 receptor antagonists. J Med Chem. 2004 Dec 16;47(26):6529-40. DMQ0DMU RU https://pubmed.ncbi.nlm.nih.gov/15588088 DMQ0DMU DI DMQ0DMU DMQ0DMU DN N-(2,6-diphenylpyrimidin-4-yl)acetamide DMQ0DMU MI TTJFY5U DMQ0DMU MN Adenosine A3 receptor (ADORA3) DMQ0DMU MT DTT DMQ0DMU MA Inhibitor DMQ0DMU RN 2,4,6-trisubstituted pyrimidines as a new class of selective adenosine A1 receptor antagonists. J Med Chem. 2004 Dec 16;47(26):6529-40. DMQ0DMU RU https://pubmed.ncbi.nlm.nih.gov/15588088 DMBW752 DI DMBW752 DMBW752 DN N-(2,6-diphenylpyrimidin-4-yl)benzamide DMBW752 MI TTK25J1 DMBW752 MN Adenosine A1 receptor (ADORA1) DMBW752 MT DTT DMBW752 MA Inhibitor DMBW752 RN 2,4,6-trisubstituted pyrimidines as a new class of selective adenosine A1 receptor antagonists. J Med Chem. 2004 Dec 16;47(26):6529-40. DMBW752 RU https://pubmed.ncbi.nlm.nih.gov/15588088 DMBW752 DI DMBW752 DMBW752 DN N-(2,6-diphenylpyrimidin-4-yl)benzamide DMBW752 MI TTJFY5U DMBW752 MN Adenosine A3 receptor (ADORA3) DMBW752 MT DTT DMBW752 MA Inhibitor DMBW752 RN 2,4,6-trisubstituted pyrimidines as a new class of selective adenosine A1 receptor antagonists. J Med Chem. 2004 Dec 16;47(26):6529-40. DMBW752 RU https://pubmed.ncbi.nlm.nih.gov/15588088 DM5EF71 DI DM5EF71 DM5EF71 DN N-(2,6-diphenylpyrimidin-4-yl)butyramide DM5EF71 MI TTK25J1 DM5EF71 MN Adenosine A1 receptor (ADORA1) DM5EF71 MT DTT DM5EF71 MA Inhibitor DM5EF71 RN 2,4,6-trisubstituted pyrimidines as a new class of selective adenosine A1 receptor antagonists. J Med Chem. 2004 Dec 16;47(26):6529-40. DM5EF71 RU https://pubmed.ncbi.nlm.nih.gov/15588088 DM5EF71 DI DM5EF71 DM5EF71 DN N-(2,6-diphenylpyrimidin-4-yl)butyramide DM5EF71 MI TTM2AOE DM5EF71 MN Adenosine A2a receptor (ADORA2A) DM5EF71 MT DTT DM5EF71 MA Inhibitor DM5EF71 RN 2,4,6-trisubstituted pyrimidines as a new class of selective adenosine A1 receptor antagonists. J Med Chem. 2004 Dec 16;47(26):6529-40. DM5EF71 RU https://pubmed.ncbi.nlm.nih.gov/15588088 DM5EF71 DI DM5EF71 DM5EF71 DN N-(2,6-diphenylpyrimidin-4-yl)butyramide DM5EF71 MI TTJFY5U DM5EF71 MN Adenosine A3 receptor (ADORA3) DM5EF71 MT DTT DM5EF71 MA Inhibitor DM5EF71 RN 2,4,6-trisubstituted pyrimidines as a new class of selective adenosine A1 receptor antagonists. J Med Chem. 2004 Dec 16;47(26):6529-40. DM5EF71 RU https://pubmed.ncbi.nlm.nih.gov/15588088 DMWPZCS DI DMWPZCS DMWPZCS DN N-(2,6-diphenylpyrimidin-4-yl)isobutyramide DMWPZCS MI TTK25J1 DMWPZCS MN Adenosine A1 receptor (ADORA1) DMWPZCS MT DTT DMWPZCS MA Inhibitor DMWPZCS RN 2,4,6-trisubstituted pyrimidines as a new class of selective adenosine A1 receptor antagonists. J Med Chem. 2004 Dec 16;47(26):6529-40. DMWPZCS RU https://pubmed.ncbi.nlm.nih.gov/15588088 DMWPZCS DI DMWPZCS DMWPZCS DN N-(2,6-diphenylpyrimidin-4-yl)isobutyramide DMWPZCS MI TTM2AOE DMWPZCS MN Adenosine A2a receptor (ADORA2A) DMWPZCS MT DTT DMWPZCS MA Inhibitor DMWPZCS RN 2,4,6-trisubstituted pyrimidines as a new class of selective adenosine A1 receptor antagonists. J Med Chem. 2004 Dec 16;47(26):6529-40. DMWPZCS RU https://pubmed.ncbi.nlm.nih.gov/15588088 DMWPZCS DI DMWPZCS DMWPZCS DN N-(2,6-diphenylpyrimidin-4-yl)isobutyramide DMWPZCS MI TTJFY5U DMWPZCS MN Adenosine A3 receptor (ADORA3) DMWPZCS MT DTT DMWPZCS MA Inhibitor DMWPZCS RN 2,4,6-trisubstituted pyrimidines as a new class of selective adenosine A1 receptor antagonists. J Med Chem. 2004 Dec 16;47(26):6529-40. DMWPZCS RU https://pubmed.ncbi.nlm.nih.gov/15588088 DM89NGE DI DM89NGE DM89NGE DN N-(2,6-diphenylpyrimidin-4-yl)propionamide DM89NGE MI TTK25J1 DM89NGE MN Adenosine A1 receptor (ADORA1) DM89NGE MT DTT DM89NGE MA Inhibitor DM89NGE RN 2,4,6-trisubstituted pyrimidines as a new class of selective adenosine A1 receptor antagonists. J Med Chem. 2004 Dec 16;47(26):6529-40. DM89NGE RU https://pubmed.ncbi.nlm.nih.gov/15588088 DM89NGE DI DM89NGE DM89NGE DN N-(2,6-diphenylpyrimidin-4-yl)propionamide DM89NGE MI TTM2AOE DM89NGE MN Adenosine A2a receptor (ADORA2A) DM89NGE MT DTT DM89NGE MA Inhibitor DM89NGE RN 2,4,6-trisubstituted pyrimidines as a new class of selective adenosine A1 receptor antagonists. J Med Chem. 2004 Dec 16;47(26):6529-40. DM89NGE RU https://pubmed.ncbi.nlm.nih.gov/15588088 DM89NGE DI DM89NGE DM89NGE DN N-(2,6-diphenylpyrimidin-4-yl)propionamide DM89NGE MI TTJFY5U DM89NGE MN Adenosine A3 receptor (ADORA3) DM89NGE MT DTT DM89NGE MA Inhibitor DM89NGE RN 2,4,6-trisubstituted pyrimidines as a new class of selective adenosine A1 receptor antagonists. J Med Chem. 2004 Dec 16;47(26):6529-40. DM89NGE RU https://pubmed.ncbi.nlm.nih.gov/15588088 DM7D3GL DI DM7D3GL DM7D3GL DN N-(2-Acetamido)Iminodiacetic Acid DM7D3GL MI TTICO5G DM7D3GL MN Staphylococcus Peptide deformylase (Stap-coc def) DM7D3GL MT DTT DM7D3GL MA Inhibitor DM7D3GL RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DM7D3GL RU https://pubmed.ncbi.nlm.nih.gov/17139284 DM6QZPH DI DM6QZPH DM6QZPH DN N-(2-adamantyl)-N'-propylsulfamide DM6QZPH MI TT6OEDT DM6QZPH MN Cannabinoid receptor 1 (CB1) DM6QZPH MT DTT DM6QZPH MA Inhibitor DM6QZPH RN Synthesis and pharmacological evaluation of sulfamide-based analogues of anandamide. Eur J Med Chem. 2009 Dec;44(12):4889-95. DM6QZPH RU https://pubmed.ncbi.nlm.nih.gov/19762126 DM7VN9P DI DM7VN9P DM7VN9P DN N-(2-amino-5-(benzofuran-2-yl)phenyl)benzamide DM7VN9P MI TTSHTOI DM7VN9P MN Histone deacetylase 2 (HDAC2) DM7VN9P MT DTT DM7VN9P MA Inhibitor DM7VN9P RN Exploration of the HDAC2 foot pocket: Synthesis and SAR of substituted N-(2-aminophenyl)benzamides. Bioorg Med Chem Lett. 2010 May 15;20(10):3142-5. DM7VN9P RU https://pubmed.ncbi.nlm.nih.gov/20392638 DMY9HO8 DI DMY9HO8 DMY9HO8 DN N-(2-amino-5-(furan-2-yl)phenyl)benzamide DMY9HO8 MI TTSHTOI DMY9HO8 MN Histone deacetylase 2 (HDAC2) DMY9HO8 MT DTT DMY9HO8 MA Inhibitor DMY9HO8 RN Exploration of the HDAC2 foot pocket: Synthesis and SAR of substituted N-(2-aminophenyl)benzamides. Bioorg Med Chem Lett. 2010 May 15;20(10):3142-5. DMY9HO8 RU https://pubmed.ncbi.nlm.nih.gov/20392638 DMI7W9N DI DMI7W9N DMI7W9N DN N-(2-amino-5-(furan-3-yl)phenyl)benzamide DMI7W9N MI TTSHTOI DMI7W9N MN Histone deacetylase 2 (HDAC2) DMI7W9N MT DTT DMI7W9N MA Inhibitor DMI7W9N RN Exploration of the HDAC2 foot pocket: Synthesis and SAR of substituted N-(2-aminophenyl)benzamides. Bioorg Med Chem Lett. 2010 May 15;20(10):3142-5. DMI7W9N RU https://pubmed.ncbi.nlm.nih.gov/20392638 DM1KVPG DI DM1KVPG DM1KVPG DN N-(2-amino-5-(pyridin-4-yl)phenyl)benzamide DM1KVPG MI TTSHTOI DM1KVPG MN Histone deacetylase 2 (HDAC2) DM1KVPG MT DTT DM1KVPG MA Inhibitor DM1KVPG RN Exploration of the HDAC2 foot pocket: Synthesis and SAR of substituted N-(2-aminophenyl)benzamides. Bioorg Med Chem Lett. 2010 May 15;20(10):3142-5. DM1KVPG RU https://pubmed.ncbi.nlm.nih.gov/20392638 DM2K0AJ DI DM2K0AJ DM2K0AJ DN N-(2-amino-5-(thiazol-2-yl)phenyl)benzamide DM2K0AJ MI TTSHTOI DM2K0AJ MN Histone deacetylase 2 (HDAC2) DM2K0AJ MT DTT DM2K0AJ MA Inhibitor DM2K0AJ RN Exploration of the HDAC2 foot pocket: Synthesis and SAR of substituted N-(2-aminophenyl)benzamides. Bioorg Med Chem Lett. 2010 May 15;20(10):3142-5. DM2K0AJ RU https://pubmed.ncbi.nlm.nih.gov/20392638 DMFYG79 DI DMFYG79 DMFYG79 DN N-(2-amino-5-(thiophen-2-yl)phenyl)nicotinamide DMFYG79 MI TTBH0VX DMFYG79 MN Histone deacetylase (HDAC) DMFYG79 MT DTT DMFYG79 MA Inhibitor DMFYG79 RN Bioorg Med Chem Lett. 2008 Dec 1;18(23):6104-9. Epub 2008 Oct 14.SAR profiles of spirocyclic nicotinamide derived selective HDAC1/HDAC2 inhibitors (SHI-1:2). DMFYG79 RU https://pubmed.ncbi.nlm.nih.gov/18951790 DMFYG79 DI DMFYG79 DMFYG79 DN N-(2-amino-5-(thiophen-2-yl)phenyl)nicotinamide DMFYG79 MI TT6R7JZ DMFYG79 MN Histone deacetylase 1 (HDAC1) DMFYG79 MT DTT DMFYG79 MA Inhibitor DMFYG79 RN Bioorg Med Chem Lett. 2008 Dec 1;18(23):6104-9. Epub 2008 Oct 14.SAR profiles of spirocyclic nicotinamide derived selective HDAC1/HDAC2 inhibitors (SHI-1:2). DMFYG79 RU https://pubmed.ncbi.nlm.nih.gov/18951790 DMFYG79 DI DMFYG79 DMFYG79 DN N-(2-amino-5-(thiophen-2-yl)phenyl)nicotinamide DMFYG79 MI TTSHTOI DMFYG79 MN Histone deacetylase 2 (HDAC2) DMFYG79 MT DTT DMFYG79 MA Inhibitor DMFYG79 RN Bioorg Med Chem Lett. 2008 Dec 1;18(23):6104-9. Epub 2008 Oct 14.SAR profiles of spirocyclic nicotinamide derived selective HDAC1/HDAC2 inhibitors (SHI-1:2). DMFYG79 RU https://pubmed.ncbi.nlm.nih.gov/18951790 DMRK4FA DI DMRK4FA DMRK4FA DN N-(2-aminoethyl)-1-aziridine-ethanamine DMRK4FA MI TTYRG7F DMRK4FA MN HUMAN angiotensin-converting enzyme 2 (ACE2) DMRK4FA MT DTT DMRK4FA MA Inhibitor DMRK4FA RN Coronaviruses - drug discovery and therapeutic options. Nat Rev Drug Discov. 2016 May;15(5):327-47. DMRK4FA RU https://pubmed.ncbi.nlm.nih.gov/26868298 DM7SUTQ DI DM7SUTQ DM7SUTQ DN N-(2-aminoethyl)-2-oxo-2H-chromene-3-carboxamide DM7SUTQ MI TTGP7BY DM7SUTQ MN Monoamine oxidase type B (MAO-B) DM7SUTQ MT DTT DM7SUTQ MA Inhibitor DM7SUTQ RN Synthesis, molecular modeling, and selective inhibitory activity against human monoamine oxidases of 3-carboxamido-7-substituted coumarins. J Med Chem. 2009 Apr 9;52(7):1935-42. DM7SUTQ RU https://pubmed.ncbi.nlm.nih.gov/19267475 DMG2MSX DI DMG2MSX DMG2MSX DN N-(2-aminoethyl)isoquinoline-5-sulfonamide DMG2MSX MI TTSFWA7 DMG2MSX MN Plasmodium CDK Pfmrk (Malaria Pfmrk) DMG2MSX MT DTT DMG2MSX MA Inhibitor DMG2MSX RN Evaluation of broad spectrum protein kinase inhibitors to probe the architecture of the malarial cyclin dependent protein kinase Pfmrk. Bioorg Med Chem Lett. 2007 Sep 1;17(17):4961-6. DMG2MSX RU https://pubmed.ncbi.nlm.nih.gov/17588749 DMLSFQI DI DMLSFQI DMLSFQI DN N-(2-aminoethyl)-p-chlorobenzamide DMLSFQI MI TTGP7BY DMLSFQI MN Monoamine oxidase type B (MAO-B) DMLSFQI MT DTT DMLSFQI MA Inhibitor DMLSFQI RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DMLSFQI RU https://pubmed.ncbi.nlm.nih.gov/10592235 DMT7JUC DI DMT7JUC DMT7JUC DN N-(2-aminophenyl)-4-(chroman-3-ylmethyl)benzamide DMT7JUC MI TT6R7JZ DMT7JUC MN Histone deacetylase 1 (HDAC1) DMT7JUC MT DTT DMT7JUC MA Inhibitor DMT7JUC RN N-(2-Amino-phenyl)-4-(heteroarylmethyl)-benzamides as new histone deacetylase inhibitors. Bioorg Med Chem Lett. 2007 Dec 15;17(24):6729-33. DMT7JUC RU https://pubmed.ncbi.nlm.nih.gov/17977726 DMTKWUM DI DMTKWUM DMTKWUM DN N-(2-aminophenyl)-4-methoxybenzamide DMTKWUM MI TTBH0VX DMTKWUM MN Histone deacetylase (HDAC) DMTKWUM MT DTT DMTKWUM MA Inhibitor DMTKWUM RN Novel aminophenyl benzamide-type histone deacetylase inhibitors with enhanced potency and selectivity. J Med Chem. 2007 Nov 15;50(23):5543-6. DMTKWUM RU https://pubmed.ncbi.nlm.nih.gov/17941625 DMTKWUM DI DMTKWUM DMTKWUM DN N-(2-aminophenyl)-4-methoxybenzamide DMTKWUM MI TT6R7JZ DMTKWUM MN Histone deacetylase 1 (HDAC1) DMTKWUM MT DTT DMTKWUM MA Inhibitor DMTKWUM RN Novel aminophenyl benzamide-type histone deacetylase inhibitors with enhanced potency and selectivity. J Med Chem. 2007 Nov 15;50(23):5543-6. DMTKWUM RU https://pubmed.ncbi.nlm.nih.gov/17941625 DMTKWUM DI DMTKWUM DMTKWUM DN N-(2-aminophenyl)-4-methoxybenzamide DMTKWUM MI TTSHTOI DMTKWUM MN Histone deacetylase 2 (HDAC2) DMTKWUM MT DTT DMTKWUM MA Inhibitor DMTKWUM RN Novel aminophenyl benzamide-type histone deacetylase inhibitors with enhanced potency and selectivity. J Med Chem. 2007 Nov 15;50(23):5543-6. DMTKWUM RU https://pubmed.ncbi.nlm.nih.gov/17941625 DM8PB90 DI DM8PB90 DM8PB90 DN N-(2-aminophenyl)benzamide DM8PB90 MI TTSHTOI DM8PB90 MN Histone deacetylase 2 (HDAC2) DM8PB90 MT DTT DM8PB90 MA Inhibitor DM8PB90 RN Exploration of the HDAC2 foot pocket: Synthesis and SAR of substituted N-(2-aminophenyl)benzamides. Bioorg Med Chem Lett. 2010 May 15;20(10):3142-5. DM8PB90 RU https://pubmed.ncbi.nlm.nih.gov/20392638 DMRDQ1B DI DMRDQ1B DMRDQ1B DN N-(2-aminophenyl)nicotinamide DMRDQ1B MI TTBH0VX DMRDQ1B MN Histone deacetylase (HDAC) DMRDQ1B MT DTT DMRDQ1B MA Inhibitor DMRDQ1B RN Bioorg Med Chem Lett. 2008 Dec 1;18(23):6104-9. Epub 2008 Oct 14.SAR profiles of spirocyclic nicotinamide derived selective HDAC1/HDAC2 inhibitors (SHI-1:2). DMRDQ1B RU https://pubmed.ncbi.nlm.nih.gov/18951790 DMRDQ1B DI DMRDQ1B DMRDQ1B DN N-(2-aminophenyl)nicotinamide DMRDQ1B MI TT6R7JZ DMRDQ1B MN Histone deacetylase 1 (HDAC1) DMRDQ1B MT DTT DMRDQ1B MA Inhibitor DMRDQ1B RN Bioorg Med Chem Lett. 2008 Dec 1;18(23):6104-9. Epub 2008 Oct 14.SAR profiles of spirocyclic nicotinamide derived selective HDAC1/HDAC2 inhibitors (SHI-1:2). DMRDQ1B RU https://pubmed.ncbi.nlm.nih.gov/18951790 DMRDQ1B DI DMRDQ1B DMRDQ1B DN N-(2-aminophenyl)nicotinamide DMRDQ1B MI TTSHTOI DMRDQ1B MN Histone deacetylase 2 (HDAC2) DMRDQ1B MT DTT DMRDQ1B MA Inhibitor DMRDQ1B RN Bioorg Med Chem Lett. 2008 Dec 1;18(23):6104-9. Epub 2008 Oct 14.SAR profiles of spirocyclic nicotinamide derived selective HDAC1/HDAC2 inhibitors (SHI-1:2). DMRDQ1B RU https://pubmed.ncbi.nlm.nih.gov/18951790 DMJXV7C DI DMJXV7C DMJXV7C DN N-(2-aminophenyl)quinoxaline-6-carboxamide DMJXV7C MI TT6R7JZ DMJXV7C MN Histone deacetylase 1 (HDAC1) DMJXV7C MT DTT DMJXV7C MA Inhibitor DMJXV7C RN Novel aminophenyl benzamide-type histone deacetylase inhibitors with enhanced potency and selectivity. J Med Chem. 2007 Nov 15;50(23):5543-6. DMJXV7C RU https://pubmed.ncbi.nlm.nih.gov/17941625 DMJXV7C DI DMJXV7C DMJXV7C DN N-(2-aminophenyl)quinoxaline-6-carboxamide DMJXV7C MI TTSHTOI DMJXV7C MN Histone deacetylase 2 (HDAC2) DMJXV7C MT DTT DMJXV7C MA Inhibitor DMJXV7C RN Novel aminophenyl benzamide-type histone deacetylase inhibitors with enhanced potency and selectivity. J Med Chem. 2007 Nov 15;50(23):5543-6. DMJXV7C RU https://pubmed.ncbi.nlm.nih.gov/17941625 DM72BSO DI DM72BSO DM72BSO DN N-(2-benzyl),N-(1-methylpyrrol-2-ylmethyl)amine DM72BSO MI TT3WG5C DM72BSO MN Monoamine oxidase type A (MAO-A) DM72BSO MT DTT DM72BSO MA Inhibitor DM72BSO RN New pyrrole inhibitors of monoamine oxidase: synthesis, biological evaluation, and structural determinants of MAO-A and MAO-B selectivity. J Med Chem. 2007 Mar 8;50(5):922-31. DM72BSO RU https://pubmed.ncbi.nlm.nih.gov/17256833 DMW5XLG DI DMW5XLG DMW5XLG DN N-(2-benzyloxy-4-nitrophenyl)methanesulfonamide DMW5XLG MI TTSZLWK DMW5XLG MN Aromatase (CYP19A1) DMW5XLG MT DTT DMW5XLG MA Inhibitor DMW5XLG RN Synthesis and biological evaluation of selective aromatase expression regulators in breast cancer cells. J Med Chem. 2007 Apr 5;50(7):1635-44. DMW5XLG RU https://pubmed.ncbi.nlm.nih.gov/17315855 DMFC564 DI DMFC564 DMFC564 DN N-(2-bromobenzoyloxy)-4-chlorobenzamide DMFC564 MI TT6804T DMFC564 MN MIF messenger RNA (MIF mRNA) DMFC564 MT DTT DMFC564 MA Inhibitor DMFC564 RN An integrative in silico methodology for the identification of modulators of macrophage migration inhibitory factor (MIF) tautomerase activity. Bioorg Med Chem. 2010 Jul 15;18(14):5425-40. DMFC564 RU https://pubmed.ncbi.nlm.nih.gov/20639113 DM4IEWG DI DM4IEWG DM4IEWG DN N-(2-chlorobenzyl)-5-(4-chlorophenyl)nicotinamide DM4IEWG MI TT90XZ8 DM4IEWG MN Voltage-gated sodium channel alpha Nav1.8 (SCN10A) DM4IEWG MT DTT DM4IEWG MA Inhibitor DM4IEWG RN Subtype-selective Na(v)1.8 sodium channel blockers: identification of potent, orally active nicotinamide derivatives. Bioorg Med Chem Lett. 2010 Nov 15;20(22):6812-5. DM4IEWG RU https://pubmed.ncbi.nlm.nih.gov/20855211 DMU5R2O DI DMU5R2O DMU5R2O DN N-(2-chloroethyl)icosa-5,8,11,14-tetraenamide DMU5R2O MI TT6OEDT DMU5R2O MN Cannabinoid receptor 1 (CB1) DMU5R2O MT DTT DMU5R2O MA Inhibitor DMU5R2O RN New 1,8-naphthyridine and quinoline derivatives as CB2 selective agonists. Bioorg Med Chem Lett. 2007 Dec 1;17(23):6505-10. DMU5R2O RU https://pubmed.ncbi.nlm.nih.gov/17942307 DMU5R2O DI DMU5R2O DMU5R2O DN N-(2-chloroethyl)icosa-5,8,11,14-tetraenamide DMU5R2O MI TTMSFAW DMU5R2O MN Cannabinoid receptor 2 (CB2) DMU5R2O MT DTT DMU5R2O MA Inhibitor DMU5R2O RN New 1,8-naphthyridine and quinoline derivatives as CB2 selective agonists. Bioorg Med Chem Lett. 2007 Dec 1;17(23):6505-10. DMU5R2O RU https://pubmed.ncbi.nlm.nih.gov/17942307 DMZ4A2X DI DMZ4A2X DMZ4A2X DN N-(2-Diethylamino-ethyl)-4-hexyloxy-benzamide DMZ4A2X MI TT846HF DMZ4A2X MN Voltage-gated potassium channel Kv7.1 (KCNQ1) DMZ4A2X MT DTT DMZ4A2X MA Inhibitor DMZ4A2X RN Design and synthesis of 4-substituted benzamides as potent, selective, and orally bioavailable I(Ks) blockers. J Med Chem. 2001 Nov 8;44(23):3764-7. DMZ4A2X RU https://pubmed.ncbi.nlm.nih.gov/11689063 DMMDXEO DI DMMDXEO DMMDXEO DN N-(2-Ethylphenyl)-5-methylbenzo[d]oxazol-2-amine DMMDXEO MI TT2J34L DMMDXEO MN Arachidonate 5-lipoxygenase (5-LOX) DMMDXEO MT DTT DMMDXEO MA Inhibitor DMMDXEO RN Synthesis and evaluation of benzoxazole derivatives as 5-lipoxygenase inhibitors. Bioorg Med Chem. 2010 Nov 1;18(21):7580-5. DMMDXEO RU https://pubmed.ncbi.nlm.nih.gov/20870413 DMDM50P DI DMDM50P DMDM50P DN N-(2-Ethylphenyl)-N'-hydroxyoctanediamide DMDM50P MI TTBH0VX DMDM50P MN Histone deacetylase (HDAC) DMDM50P MT DTT DMDM50P MA Inhibitor DMDM50P RN Biological and biophysical properties of the histone deacetylase inhibitor suberoylanilide hydroxamic acid are affected by the presence of short al... J Med Chem. 2010 Mar 11;53(5):1937-50. DMDM50P RU https://pubmed.ncbi.nlm.nih.gov/20143840 DMDM50P DI DMDM50P DMDM50P DN N-(2-Ethylphenyl)-N'-hydroxyoctanediamide DMDM50P MI TT6R7JZ DMDM50P MN Histone deacetylase 1 (HDAC1) DMDM50P MT DTT DMDM50P MA Inhibitor DMDM50P RN Biological and biophysical properties of the histone deacetylase inhibitor suberoylanilide hydroxamic acid are affected by the presence of short al... J Med Chem. 2010 Mar 11;53(5):1937-50. DMDM50P RU https://pubmed.ncbi.nlm.nih.gov/20143840 DM3CZVW DI DM3CZVW DM3CZVW DN N-(2-Flouro-Benzyl)-4-Sulfamoyl-Benzamide DM3CZVW MI TTANPDJ DM3CZVW MN Carbonic anhydrase II (CA-II) DM3CZVW MT DTT DM3CZVW MA Inhibitor DM3CZVW RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DM3CZVW RU https://pubmed.ncbi.nlm.nih.gov/17139284 DM7BKUQ DI DM7BKUQ DM7BKUQ DN N'-(2-fluorobenzoyl)-2-naphthohydrazide DM7BKUQ MI TTSFWA7 DM7BKUQ MN Plasmodium CDK Pfmrk (Malaria Pfmrk) DM7BKUQ MT DTT DM7BKUQ MA Inhibitor DM7BKUQ RN Activity of substituted thiophene sulfonamides against malarial and mammalian cyclin dependent protein kinases, Bioorg. Med. Chem. Lett. 20(13):3863-3867 (2010). DM7BKUQ RU http://www.sciencedirect.com/science/article/pii/S0960894X10006803 DM27L53 DI DM27L53 DM27L53 DN N-(2-hexyloxy-4-nitrophenyl)methanesulfonamide DM27L53 MI TTSZLWK DM27L53 MN Aromatase (CYP19A1) DM27L53 MT DTT DM27L53 MA Inhibitor DM27L53 RN Novel sulfonanilide analogues suppress aromatase expression and activity in breast cancer cells independent of COX-2 inhibition. J Med Chem. 2006 Feb 23;49(4):1413-9. DM27L53 RU https://pubmed.ncbi.nlm.nih.gov/16480277 DM97MGE DI DM97MGE DM97MGE DN N-(2-hydroxyethyl)linoleoylamide DM97MGE MI TTDP1UC DM97MGE MN Fatty acid amide hydrolase (FAAH) DM97MGE MT DTT DM97MGE MA Inhibitor DM97MGE RN Radiosynthesis, in vitro and in vivo evaluation of 123I-labeled anandamide analogues for mapping brain FAAH. Bioorg Med Chem. 2009 Jan 1;17(1):49-56. DM97MGE RU https://pubmed.ncbi.nlm.nih.gov/19054678 DM8ORQ4 DI DM8ORQ4 DM8ORQ4 DN N-(2-iodethyl)arachidonylamide DM8ORQ4 MI TTDP1UC DM8ORQ4 MN Fatty acid amide hydrolase (FAAH) DM8ORQ4 MT DTT DM8ORQ4 MA Inhibitor DM8ORQ4 RN Radiosynthesis, in vitro and in vivo evaluation of 123I-labeled anandamide analogues for mapping brain FAAH. Bioorg Med Chem. 2009 Jan 1;17(1):49-56. DM8ORQ4 RU https://pubmed.ncbi.nlm.nih.gov/19054678 DMV84PQ DI DMV84PQ DMV84PQ DN N-(2-iodoethyl)linoleoylamide DMV84PQ MI TTDP1UC DMV84PQ MN Fatty acid amide hydrolase (FAAH) DMV84PQ MT DTT DMV84PQ MA Inhibitor DMV84PQ RN Radiosynthesis, in vitro and in vivo evaluation of 123I-labeled anandamide analogues for mapping brain FAAH. Bioorg Med Chem. 2009 Jan 1;17(1):49-56. DMV84PQ RU https://pubmed.ncbi.nlm.nih.gov/19054678 DM0GOPV DI DM0GOPV DM0GOPV DN N-(2-Mercapto-ethyl)-N'-phenyl-oxalamide DM0GOPV MI TTBH0VX DM0GOPV MN Histone deacetylase (HDAC) DM0GOPV MT DTT DM0GOPV MA Inhibitor DM0GOPV RN Mercaptoamide-based non-hydroxamic acid type histone deacetylase inhibitors. Bioorg Med Chem Lett. 2005 Apr 15;15(8):1969-72. DM0GOPV RU https://pubmed.ncbi.nlm.nih.gov/15808449 DM0GOPV DI DM0GOPV DM0GOPV DN N-(2-Mercapto-ethyl)-N'-phenyl-oxalamide DM0GOPV MI TT6R7JZ DM0GOPV MN Histone deacetylase 1 (HDAC1) DM0GOPV MT DTT DM0GOPV MA Inhibitor DM0GOPV RN Mercaptoamide-based non-hydroxamic acid type histone deacetylase inhibitors. Bioorg Med Chem Lett. 2005 Apr 15;15(8):1969-72. DM0GOPV RU https://pubmed.ncbi.nlm.nih.gov/15808449 DM0GOPV DI DM0GOPV DM0GOPV DN N-(2-Mercapto-ethyl)-N'-phenyl-oxalamide DM0GOPV MI TTYHPU6 DM0GOPV MN Histone deacetylase 10 (HDAC10) DM0GOPV MT DTT DM0GOPV MA Inhibitor DM0GOPV RN Mercaptoamide-based non-hydroxamic acid type histone deacetylase inhibitors. Bioorg Med Chem Lett. 2005 Apr 15;15(8):1969-72. DM0GOPV RU https://pubmed.ncbi.nlm.nih.gov/15808449 DM0GOPV DI DM0GOPV DM0GOPV DN N-(2-Mercapto-ethyl)-N'-phenyl-oxalamide DM0GOPV MI TTSHTOI DM0GOPV MN Histone deacetylase 2 (HDAC2) DM0GOPV MT DTT DM0GOPV MA Inhibitor DM0GOPV RN Mercaptoamide-based non-hydroxamic acid type histone deacetylase inhibitors. Bioorg Med Chem Lett. 2005 Apr 15;15(8):1969-72. DM0GOPV RU https://pubmed.ncbi.nlm.nih.gov/15808449 DM0GOPV DI DM0GOPV DM0GOPV DN N-(2-Mercapto-ethyl)-N'-phenyl-oxalamide DM0GOPV MI TTTQGH8 DM0GOPV MN Histone deacetylase 4 (HDAC4) DM0GOPV MT DTT DM0GOPV MA Inhibitor DM0GOPV RN Mercaptoamide-based non-hydroxamic acid type histone deacetylase inhibitors. Bioorg Med Chem Lett. 2005 Apr 15;15(8):1969-72. DM0GOPV RU https://pubmed.ncbi.nlm.nih.gov/15808449 DM0GOPV DI DM0GOPV DM0GOPV DN N-(2-Mercapto-ethyl)-N'-phenyl-oxalamide DM0GOPV MI TT5ZKDI DM0GOPV MN Histone deacetylase 6 (HDAC6) DM0GOPV MT DTT DM0GOPV MA Inhibitor DM0GOPV RN Mercaptoamide-based non-hydroxamic acid type histone deacetylase inhibitors. Bioorg Med Chem Lett. 2005 Apr 15;15(8):1969-72. DM0GOPV RU https://pubmed.ncbi.nlm.nih.gov/15808449 DM0GOPV DI DM0GOPV DM0GOPV DN N-(2-Mercapto-ethyl)-N'-phenyl-oxalamide DM0GOPV MI TTT6LFV DM0GOPV MN Histone deacetylase 8 (HDAC8) DM0GOPV MT DTT DM0GOPV MA Inhibitor DM0GOPV RN Mercaptoamide-based non-hydroxamic acid type histone deacetylase inhibitors. Bioorg Med Chem Lett. 2005 Apr 15;15(8):1969-72. DM0GOPV RU https://pubmed.ncbi.nlm.nih.gov/15808449 DMJLFOQ DI DMJLFOQ DMJLFOQ DN N-(2-Mercapto-ethyl)-N'-phenyl-succinamide DMJLFOQ MI TTBH0VX DMJLFOQ MN Histone deacetylase (HDAC) DMJLFOQ MT DTT DMJLFOQ MA Inhibitor DMJLFOQ RN Mercaptoamide-based non-hydroxamic acid type histone deacetylase inhibitors. Bioorg Med Chem Lett. 2005 Apr 15;15(8):1969-72. DMJLFOQ RU https://pubmed.ncbi.nlm.nih.gov/15808449 DMJLFOQ DI DMJLFOQ DMJLFOQ DN N-(2-Mercapto-ethyl)-N'-phenyl-succinamide DMJLFOQ MI TT6R7JZ DMJLFOQ MN Histone deacetylase 1 (HDAC1) DMJLFOQ MT DTT DMJLFOQ MA Inhibitor DMJLFOQ RN Mercaptoamide-based non-hydroxamic acid type histone deacetylase inhibitors. Bioorg Med Chem Lett. 2005 Apr 15;15(8):1969-72. DMJLFOQ RU https://pubmed.ncbi.nlm.nih.gov/15808449 DMJLFOQ DI DMJLFOQ DMJLFOQ DN N-(2-Mercapto-ethyl)-N'-phenyl-succinamide DMJLFOQ MI TTYHPU6 DMJLFOQ MN Histone deacetylase 10 (HDAC10) DMJLFOQ MT DTT DMJLFOQ MA Inhibitor DMJLFOQ RN Mercaptoamide-based non-hydroxamic acid type histone deacetylase inhibitors. Bioorg Med Chem Lett. 2005 Apr 15;15(8):1969-72. DMJLFOQ RU https://pubmed.ncbi.nlm.nih.gov/15808449 DMJLFOQ DI DMJLFOQ DMJLFOQ DN N-(2-Mercapto-ethyl)-N'-phenyl-succinamide DMJLFOQ MI TTSHTOI DMJLFOQ MN Histone deacetylase 2 (HDAC2) DMJLFOQ MT DTT DMJLFOQ MA Inhibitor DMJLFOQ RN Mercaptoamide-based non-hydroxamic acid type histone deacetylase inhibitors. Bioorg Med Chem Lett. 2005 Apr 15;15(8):1969-72. DMJLFOQ RU https://pubmed.ncbi.nlm.nih.gov/15808449 DMJLFOQ DI DMJLFOQ DMJLFOQ DN N-(2-Mercapto-ethyl)-N'-phenyl-succinamide DMJLFOQ MI TTTQGH8 DMJLFOQ MN Histone deacetylase 4 (HDAC4) DMJLFOQ MT DTT DMJLFOQ MA Inhibitor DMJLFOQ RN Mercaptoamide-based non-hydroxamic acid type histone deacetylase inhibitors. Bioorg Med Chem Lett. 2005 Apr 15;15(8):1969-72. DMJLFOQ RU https://pubmed.ncbi.nlm.nih.gov/15808449 DMJLFOQ DI DMJLFOQ DMJLFOQ DN N-(2-Mercapto-ethyl)-N'-phenyl-succinamide DMJLFOQ MI TT5ZKDI DMJLFOQ MN Histone deacetylase 6 (HDAC6) DMJLFOQ MT DTT DMJLFOQ MA Inhibitor DMJLFOQ RN Mercaptoamide-based non-hydroxamic acid type histone deacetylase inhibitors. Bioorg Med Chem Lett. 2005 Apr 15;15(8):1969-72. DMJLFOQ RU https://pubmed.ncbi.nlm.nih.gov/15808449 DMJLFOQ DI DMJLFOQ DMJLFOQ DN N-(2-Mercapto-ethyl)-N'-phenyl-succinamide DMJLFOQ MI TTT6LFV DMJLFOQ MN Histone deacetylase 8 (HDAC8) DMJLFOQ MT DTT DMJLFOQ MA Inhibitor DMJLFOQ RN Mercaptoamide-based non-hydroxamic acid type histone deacetylase inhibitors. Bioorg Med Chem Lett. 2005 Apr 15;15(8):1969-72. DMJLFOQ RU https://pubmed.ncbi.nlm.nih.gov/15808449 DM06S5Z DI DM06S5Z DM06S5Z DN N-(2-methoxybenzyl)cinnamamidine DM06S5Z MI TTLD29N DM06S5Z MN Glutamate receptor ionotropic NMDA 1 (NMDAR1) DM06S5Z MT DTT DM06S5Z MA Inhibitor DM06S5Z RN Indole-2-carboxamidines as novel NR2B selective NMDA receptor antagonists. Bioorg Med Chem Lett. 2005 Dec 15;15(24):5439-41. DM06S5Z RU https://pubmed.ncbi.nlm.nih.gov/16213709 DM06S5Z DI DM06S5Z DM06S5Z DN N-(2-methoxybenzyl)cinnamamidine DM06S5Z MI TTKJEMQ DM06S5Z MN Glutamate receptor ionotropic NMDA 2A (NMDAR2A) DM06S5Z MT DTT DM06S5Z MA Inhibitor DM06S5Z RN Indole-2-carboxamidines as novel NR2B selective NMDA receptor antagonists. Bioorg Med Chem Lett. 2005 Dec 15;15(24):5439-41. DM06S5Z RU https://pubmed.ncbi.nlm.nih.gov/16213709 DM06S5Z DI DM06S5Z DM06S5Z DN N-(2-methoxybenzyl)cinnamamidine DM06S5Z MI TTN9D8E DM06S5Z MN Glutamate receptor ionotropic NMDA 2B (NMDAR2B) DM06S5Z MT DTT DM06S5Z MA Inhibitor DM06S5Z RN Indole-2-carboxamidines as novel NR2B selective NMDA receptor antagonists. Bioorg Med Chem Lett. 2005 Dec 15;15(24):5439-41. DM06S5Z RU https://pubmed.ncbi.nlm.nih.gov/16213709 DMH42YF DI DMH42YF DMH42YF DN N-(2-Methyl-1H-indol-5-yl)benzamide DMH42YF MI TTGP7BY DMH42YF MN Monoamine oxidase type B (MAO-B) DMH42YF MT DTT DMH42YF MA Inhibitor DMH42YF RN Inhibition of monoamine oxidase by indole and benzofuran derivatives. Eur J Med Chem. 2010 Oct;45(10):4458-66. DMH42YF RU https://pubmed.ncbi.nlm.nih.gov/20674099 DM3SF5M DI DM3SF5M DM3SF5M DN N-(2-Methyl-1H-indol-5-yl)cyclohexanecarboxamide DM3SF5M MI TT3WG5C DM3SF5M MN Monoamine oxidase type A (MAO-A) DM3SF5M MT DTT DM3SF5M MA Inhibitor DM3SF5M RN Inhibition of monoamine oxidase by indole and benzofuran derivatives. Eur J Med Chem. 2010 Oct;45(10):4458-66. DM3SF5M RU https://pubmed.ncbi.nlm.nih.gov/20674099 DM3SF5M DI DM3SF5M DM3SF5M DN N-(2-Methyl-1H-indol-5-yl)cyclohexanecarboxamide DM3SF5M MI TTGP7BY DM3SF5M MN Monoamine oxidase type B (MAO-B) DM3SF5M MT DTT DM3SF5M MA Inhibitor DM3SF5M RN Inhibition of monoamine oxidase by indole and benzofuran derivatives. Eur J Med Chem. 2010 Oct;45(10):4458-66. DM3SF5M RU https://pubmed.ncbi.nlm.nih.gov/20674099 DMXRSM1 DI DMXRSM1 DMXRSM1 DN N-(2-methyl-2-phenylpropyl)pyrazine-2-carboxamide DMXRSM1 MI TTVBPDM DMXRSM1 MN Metabotropic glutamate receptor 1 (mGluR1) DMXRSM1 MT DTT DMXRSM1 MA Inhibitor DMXRSM1 RN Structure-activity relationships of novel non-competitive mGluR1 antagonists: a potential treatment for chronic pain. Bioorg Med Chem Lett. 2007 Jan 15;17(2):486-90. DMXRSM1 RU https://pubmed.ncbi.nlm.nih.gov/17064898 DMI4KNB DI DMI4KNB DMI4KNB DN N-(2-morpholinophenyl)-5-nitrofuran-2-carboxamide DMI4KNB MI TTC70AJ DMI4KNB MN Granulocyte colony-stimulating factor receptor (G-CSF-R) DMI4KNB MT DTT DMI4KNB MA Inhibitor DMI4KNB RN Potent 2'-aminoanilide inhibitors of cFMS as potential anti-inflammatory agents. Bioorg Med Chem Lett. 2007 Nov 15;17(22):6070-4. DMI4KNB RU https://pubmed.ncbi.nlm.nih.gov/17904845 DMF5N4O DI DMF5N4O DMF5N4O DN N-(2-naphthylsulfonyl)-glycyl-glycine-nitrile DMF5N4O MI TTUMQVO DMF5N4O MN Cathepsin S (CTSS) DMF5N4O MT DTT DMF5N4O MA Inhibitor DMF5N4O RN Interaction of papain-like cysteine proteases with dipeptide-derived nitriles. J Med Chem. 2005 Dec 1;48(24):7688-707. DMF5N4O RU https://pubmed.ncbi.nlm.nih.gov/16302809 DMU6FPL DI DMU6FPL DMU6FPL DN N-(2-nonyloxy-4-nitrophenyl)methanesulfonamide DMU6FPL MI TTSZLWK DMU6FPL MN Aromatase (CYP19A1) DMU6FPL MT DTT DMU6FPL MA Inhibitor DMU6FPL RN Novel sulfonanilide analogues suppress aromatase expression and activity in breast cancer cells independent of COX-2 inhibition. J Med Chem. 2006 Feb 23;49(4):1413-9. DMU6FPL RU https://pubmed.ncbi.nlm.nih.gov/16480277 DMVGP02 DI DMVGP02 DMVGP02 DN N-(2-oxazolemethyl)milnacipran DMVGP02 MI TTAWNKZ DMVGP02 MN Norepinephrine transporter (NET) DMVGP02 MT DTT DMVGP02 MA Inhibitor DMVGP02 RN Studies on the SAR and pharmacophore of milnacipran derivatives as monoamine transporter inhibitors. Bioorg Med Chem Lett. 2008 Feb 15;18(4):1346-9. DMVGP02 RU https://pubmed.ncbi.nlm.nih.gov/18207394 DMVGP02 DI DMVGP02 DMVGP02 DN N-(2-oxazolemethyl)milnacipran DMVGP02 MI TT3ROYC DMVGP02 MN Serotonin transporter (SERT) DMVGP02 MT DTT DMVGP02 MA Inhibitor DMVGP02 RN Studies on the SAR and pharmacophore of milnacipran derivatives as monoamine transporter inhibitors. Bioorg Med Chem Lett. 2008 Feb 15;18(4):1346-9. DMVGP02 RU https://pubmed.ncbi.nlm.nih.gov/18207394 DMBR1MX DI DMBR1MX DMBR1MX DN N'-(2-phenylallyl)hydrazine hydrochloride DMBR1MX MI TT3WG5C DMBR1MX MN Monoamine oxidase type A (MAO-A) DMBR1MX MT DTT DMBR1MX MA Inhibitor DMBR1MX RN Design, synthesis, and biological evaluation of semicarbazide-sensitive amine oxidase (SSAO) inhibitors with anti-inflammatory activity. J Med Chem. 2006 Apr 6;49(7):2166-73. DMBR1MX RU https://pubmed.ncbi.nlm.nih.gov/16570912 DM1ADE5 DI DM1ADE5 DM1ADE5 DN N-(2-phenylethyl),N-(pyrrol-2-ylmethyl)amine DM1ADE5 MI TT3WG5C DM1ADE5 MN Monoamine oxidase type A (MAO-A) DM1ADE5 MT DTT DM1ADE5 MA Inhibitor DM1ADE5 RN New pyrrole inhibitors of monoamine oxidase: synthesis, biological evaluation, and structural determinants of MAO-A and MAO-B selectivity. J Med Chem. 2007 Mar 8;50(5):922-31. DM1ADE5 RU https://pubmed.ncbi.nlm.nih.gov/17256833 DM1ADE5 DI DM1ADE5 DM1ADE5 DN N-(2-phenylethyl),N-(pyrrol-2-ylmethyl)amine DM1ADE5 MI TTGP7BY DM1ADE5 MN Monoamine oxidase type B (MAO-B) DM1ADE5 MT DTT DM1ADE5 MA Inhibitor DM1ADE5 RN New pyrrole inhibitors of monoamine oxidase: synthesis, biological evaluation, and structural determinants of MAO-A and MAO-B selectivity. J Med Chem. 2007 Mar 8;50(5):922-31. DM1ADE5 RU https://pubmed.ncbi.nlm.nih.gov/17256833 DMJCO7F DI DMJCO7F DMJCO7F DN N-(2-Phenylethyl)-1H-indole-2-carboxamide DMJCO7F MI TT3WG5C DMJCO7F MN Monoamine oxidase type A (MAO-A) DMJCO7F MT DTT DMJCO7F MA Inhibitor DMJCO7F RN Synthesis, structure-activity relationships and molecular modeling studies of new indole inhibitors of monoamine oxidases A and B. Bioorg Med Chem. 2008 Nov 15;16(22):9729-40. DMJCO7F RU https://pubmed.ncbi.nlm.nih.gov/18951803 DMJCO7F DI DMJCO7F DMJCO7F DN N-(2-Phenylethyl)-1H-indole-2-carboxamide DMJCO7F MI TTGP7BY DMJCO7F MN Monoamine oxidase type B (MAO-B) DMJCO7F MT DTT DMJCO7F MA Inhibitor DMJCO7F RN Synthesis, structure-activity relationships and molecular modeling studies of new indole inhibitors of monoamine oxidases A and B. Bioorg Med Chem. 2008 Nov 15;16(22):9729-40. DMJCO7F RU https://pubmed.ncbi.nlm.nih.gov/18951803 DMUILX8 DI DMUILX8 DMUILX8 DN N-(2-phenylimidazo[1,2-a]pyridin-3-yl)benzamide DMUILX8 MI TTHS256 DMUILX8 MN Metabotropic glutamate receptor 5 (mGluR5) DMUILX8 MT DTT DMUILX8 MA Inhibitor DMUILX8 RN Substituent effects of N-(1,3-diphenyl-1H-pyrazol-5-yl)benzamides on positive allosteric modulation of the metabotropic glutamate-5 receptor in rat... J Med Chem. 2006 Jun 1;49(11):3332-44. DMUILX8 RU https://pubmed.ncbi.nlm.nih.gov/16722652 DMA1LRF DI DMA1LRF DMA1LRF DN N-(2-phenylpropyl)quinoxaline-2-carboxamide DMA1LRF MI TTVBPDM DMA1LRF MN Metabotropic glutamate receptor 1 (mGluR1) DMA1LRF MT DTT DMA1LRF MA Inhibitor DMA1LRF RN Structure-activity relationships of novel non-competitive mGluR1 antagonists: a potential treatment for chronic pain. Bioorg Med Chem Lett. 2007 Jan 15;17(2):486-90. DMA1LRF RU https://pubmed.ncbi.nlm.nih.gov/17064898 DMAQMXJ DI DMAQMXJ DMAQMXJ DN N-(2-Propyloxy-4-nitrophenyl)methanesulfonamide DMAQMXJ MI TTSZLWK DMAQMXJ MN Aromatase (CYP19A1) DMAQMXJ MT DTT DMAQMXJ MA Inhibitor DMAQMXJ RN Novel sulfonanilide analogues suppress aromatase expression and activity in breast cancer cells independent of COX-2 inhibition. J Med Chem. 2006 Feb 23;49(4):1413-9. DMAQMXJ RU https://pubmed.ncbi.nlm.nih.gov/16480277 DME9HNO DI DME9HNO DME9HNO DN N-(2-Thienylmethyl)-2,5-Thiophenedisulfonamide DME9HNO MI TTANPDJ DME9HNO MN Carbonic anhydrase II (CA-II) DME9HNO MT DTT DME9HNO MA Inhibitor DME9HNO RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DME9HNO RU https://pubmed.ncbi.nlm.nih.gov/17139284 DM0JE7H DI DM0JE7H DM0JE7H DN N-(3-(1H-indol-4-yloxy)propyl)cyclohexanamine DM0JE7H MI TTSQIFT DM0JE7H MN 5-HT 1A receptor (HTR1A) DM0JE7H MT DTT DM0JE7H MA Inhibitor DM0JE7H RN Indoloxypropanolamine analogues as 5-HT(1A) receptor antagonists. Bioorg Med Chem Lett. 2007 Oct 15;17(20):5600-4. DM0JE7H RU https://pubmed.ncbi.nlm.nih.gov/17804228 DM2URTK DI DM2URTK DM2URTK DN N-(3-(1H-indol-4-yloxy)propyl)cyclopentanamine DM2URTK MI TTSQIFT DM2URTK MN 5-HT 1A receptor (HTR1A) DM2URTK MT DTT DM2URTK MA Inhibitor DM2URTK RN Indoloxypropanolamine analogues as 5-HT(1A) receptor antagonists. Bioorg Med Chem Lett. 2007 Oct 15;17(20):5600-4. DM2URTK RU https://pubmed.ncbi.nlm.nih.gov/17804228 DM4ZTF1 DI DM4ZTF1 DM4ZTF1 DN N-(3-(2,5-dimethoxyphenyl)propyl)acetamide DM4ZTF1 MI TT0WAIE DM4ZTF1 MN Melatonin receptor type 1A (MTNR1A) DM4ZTF1 MT DTT DM4ZTF1 MA Inhibitor DM4ZTF1 RN Synthesis of substituted N-[3-(3-methoxyphenyl)propyl] amides as highly potent MT(2)-selective melatonin ligands. Bioorg Med Chem Lett. 2010 Apr 15;20(8):2582-5. DM4ZTF1 RU https://pubmed.ncbi.nlm.nih.gov/20227878 DM4ZTF1 DI DM4ZTF1 DM4ZTF1 DN N-(3-(2,5-dimethoxyphenyl)propyl)acetamide DM4ZTF1 MI TT32JK8 DM4ZTF1 MN Melatonin receptor type 1B (MTNR1B) DM4ZTF1 MT DTT DM4ZTF1 MA Inhibitor DM4ZTF1 RN Synthesis of substituted N-[3-(3-methoxyphenyl)propyl] amides as highly potent MT(2)-selective melatonin ligands. Bioorg Med Chem Lett. 2010 Apr 15;20(8):2582-5. DM4ZTF1 RU https://pubmed.ncbi.nlm.nih.gov/20227878 DMP8547 DI DMP8547 DMP8547 DN N-(3-(2-aminoethyl)phenyl)benzenesulfonamide DMP8547 MI TTJS8PY DMP8547 MN 5-HT 6 receptor (HTR6) DMP8547 MT DTT DMP8547 MA Inhibitor DMP8547 RN Binding of sulfonyl-containing arylalkylamines at human 5-HT6 serotonin receptors. J Med Chem. 2006 Aug 24;49(17):5217-25. DMP8547 RU https://pubmed.ncbi.nlm.nih.gov/16913710 DMLWGPC DI DMLWGPC DMLWGPC DN N-(3-(2-ethoxy-5-methoxyphenyl)propyl)acetamide DMLWGPC MI TT0WAIE DMLWGPC MN Melatonin receptor type 1A (MTNR1A) DMLWGPC MT DTT DMLWGPC MA Inhibitor DMLWGPC RN Synthesis of substituted N-[3-(3-methoxyphenyl)propyl] amides as highly potent MT(2)-selective melatonin ligands. Bioorg Med Chem Lett. 2010 Apr 15;20(8):2582-5. DMLWGPC RU https://pubmed.ncbi.nlm.nih.gov/20227878 DMLWGPC DI DMLWGPC DMLWGPC DN N-(3-(2-ethoxy-5-methoxyphenyl)propyl)acetamide DMLWGPC MI TT32JK8 DMLWGPC MN Melatonin receptor type 1B (MTNR1B) DMLWGPC MT DTT DMLWGPC MA Inhibitor DMLWGPC RN Synthesis of substituted N-[3-(3-methoxyphenyl)propyl] amides as highly potent MT(2)-selective melatonin ligands. Bioorg Med Chem Lett. 2010 Apr 15;20(8):2582-5. DMLWGPC RU https://pubmed.ncbi.nlm.nih.gov/20227878 DMI452E DI DMI452E DMI452E DN N-(3-(2-hydroxy-5-methoxyphenyl)propyl)acetamide DMI452E MI TT0WAIE DMI452E MN Melatonin receptor type 1A (MTNR1A) DMI452E MT DTT DMI452E MA Inhibitor DMI452E RN Synthesis of substituted N-[3-(3-methoxyphenyl)propyl] amides as highly potent MT(2)-selective melatonin ligands. Bioorg Med Chem Lett. 2010 Apr 15;20(8):2582-5. DMI452E RU https://pubmed.ncbi.nlm.nih.gov/20227878 DMI452E DI DMI452E DMI452E DN N-(3-(2-hydroxy-5-methoxyphenyl)propyl)acetamide DMI452E MI TT32JK8 DMI452E MN Melatonin receptor type 1B (MTNR1B) DMI452E MT DTT DMI452E MA Inhibitor DMI452E RN Synthesis of substituted N-[3-(3-methoxyphenyl)propyl] amides as highly potent MT(2)-selective melatonin ligands. Bioorg Med Chem Lett. 2010 Apr 15;20(8):2582-5. DMI452E RU https://pubmed.ncbi.nlm.nih.gov/20227878 DMW59AY DI DMW59AY DMW59AY DN N-(3-(3-aminopropyl)phenyl)benzenesulfonamide DMW59AY MI TTJS8PY DMW59AY MN 5-HT 6 receptor (HTR6) DMW59AY MT DTT DMW59AY MA Inhibitor DMW59AY RN Binding of sulfonyl-containing arylalkylamines at human 5-HT6 serotonin receptors. J Med Chem. 2006 Aug 24;49(17):5217-25. DMW59AY RU https://pubmed.ncbi.nlm.nih.gov/16913710 DMXL70A DI DMXL70A DMXL70A DN N-(3-(3-cyanobenzamido)phenyl)-2-methoxybenzamide DMXL70A MI TTHS256 DMXL70A MN Metabotropic glutamate receptor 5 (mGluR5) DMXL70A MT DTT DMXL70A MA Inhibitor DMXL70A RN Synthesis and SAR of novel, non-MPEP chemotype mGluR5 NAMs identified by functional HTS. Bioorg Med Chem Lett. 2009 Dec 1;19(23):6502-6. DMXL70A RU https://pubmed.ncbi.nlm.nih.gov/19875287 DMH0LOT DI DMH0LOT DMH0LOT DN N-(3-(3-methoxyphenyl)-3-phenylallyl)acetamide DMH0LOT MI TT0WAIE DMH0LOT MN Melatonin receptor type 1A (MTNR1A) DMH0LOT MT DTT DMH0LOT MA Inhibitor DMH0LOT RN 2-[(2,3-dihydro-1H-indol-1-yl)methyl]melatonin analogues: a novel class of MT2-selective melatonin receptor antagonists. J Med Chem. 2009 Feb 12;52(3):826-33. DMH0LOT RU https://pubmed.ncbi.nlm.nih.gov/19193160 DMH0LOT DI DMH0LOT DMH0LOT DN N-(3-(3-methoxyphenyl)-3-phenylallyl)acetamide DMH0LOT MI TT32JK8 DMH0LOT MN Melatonin receptor type 1B (MTNR1B) DMH0LOT MT DTT DMH0LOT MA Inhibitor DMH0LOT RN 2-[(2,3-dihydro-1H-indol-1-yl)methyl]melatonin analogues: a novel class of MT2-selective melatonin receptor antagonists. J Med Chem. 2009 Feb 12;52(3):826-33. DMH0LOT RU https://pubmed.ncbi.nlm.nih.gov/19193160 DMSZ03N DI DMSZ03N DMSZ03N DN N-(3-(3-methoxyphenyl)propyl)acetamide DMSZ03N MI TT0WAIE DMSZ03N MN Melatonin receptor type 1A (MTNR1A) DMSZ03N MT DTT DMSZ03N MA Inhibitor DMSZ03N RN Synthesis of substituted N-[3-(3-methoxyphenyl)propyl] amides as highly potent MT(2)-selective melatonin ligands. Bioorg Med Chem Lett. 2010 Apr 15;20(8):2582-5. DMSZ03N RU https://pubmed.ncbi.nlm.nih.gov/20227878 DMSZ03N DI DMSZ03N DMSZ03N DN N-(3-(3-methoxyphenyl)propyl)acetamide DMSZ03N MI TT32JK8 DMSZ03N MN Melatonin receptor type 1B (MTNR1B) DMSZ03N MT DTT DMSZ03N MA Inhibitor DMSZ03N RN Synthesis of substituted N-[3-(3-methoxyphenyl)propyl] amides as highly potent MT(2)-selective melatonin ligands. Bioorg Med Chem Lett. 2010 Apr 15;20(8):2582-5. DMSZ03N RU https://pubmed.ncbi.nlm.nih.gov/20227878 DMKSM5A DI DMKSM5A DMKSM5A DN N-(3-(3-methoxyphenyl)propyl)propionamide DMKSM5A MI TT0WAIE DMKSM5A MN Melatonin receptor type 1A (MTNR1A) DMKSM5A MT DTT DMKSM5A MA Inhibitor DMKSM5A RN Synthesis of substituted N-[3-(3-methoxyphenyl)propyl] amides as highly potent MT(2)-selective melatonin ligands. Bioorg Med Chem Lett. 2010 Apr 15;20(8):2582-5. DMKSM5A RU https://pubmed.ncbi.nlm.nih.gov/20227878 DMKSM5A DI DMKSM5A DMKSM5A DN N-(3-(3-methoxyphenyl)propyl)propionamide DMKSM5A MI TT32JK8 DMKSM5A MN Melatonin receptor type 1B (MTNR1B) DMKSM5A MT DTT DMKSM5A MA Inhibitor DMKSM5A RN Synthesis of substituted N-[3-(3-methoxyphenyl)propyl] amides as highly potent MT(2)-selective melatonin ligands. Bioorg Med Chem Lett. 2010 Apr 15;20(8):2582-5. DMKSM5A RU https://pubmed.ncbi.nlm.nih.gov/20227878 DMOCZVB DI DMOCZVB DMOCZVB DN N-(3-(4-hexyl-2-hydroxyphenoxy)phenyl)acetamide DMOCZVB MI TTVTX4N DMOCZVB MN Bacterial Fatty acid synthetase I (Bact inhA) DMOCZVB MT DTT DMOCZVB MA Inhibitor DMOCZVB RN Synthesis and in vitro antimycobacterial activity of B-ring modified diaryl ether InhA inhibitors. Bioorg Med Chem Lett. 2008 May 15;18(10):3029-33. DMOCZVB RU https://pubmed.ncbi.nlm.nih.gov/18457948 DMILWPS DI DMILWPS DMILWPS DN N-(3-(4-hydroxy-3-methoxyphenyl)propyl)acetamide DMILWPS MI TT0WAIE DMILWPS MN Melatonin receptor type 1A (MTNR1A) DMILWPS MT DTT DMILWPS MA Inhibitor DMILWPS RN Synthesis of substituted N-[3-(3-methoxyphenyl)propyl] amides as highly potent MT(2)-selective melatonin ligands. Bioorg Med Chem Lett. 2010 Apr 15;20(8):2582-5. DMILWPS RU https://pubmed.ncbi.nlm.nih.gov/20227878 DMILWPS DI DMILWPS DMILWPS DN N-(3-(4-hydroxy-3-methoxyphenyl)propyl)acetamide DMILWPS MI TT32JK8 DMILWPS MN Melatonin receptor type 1B (MTNR1B) DMILWPS MT DTT DMILWPS MA Inhibitor DMILWPS RN Synthesis of substituted N-[3-(3-methoxyphenyl)propyl] amides as highly potent MT(2)-selective melatonin ligands. Bioorg Med Chem Lett. 2010 Apr 15;20(8):2582-5. DMILWPS RU https://pubmed.ncbi.nlm.nih.gov/20227878 DMHM0WI DI DMHM0WI DMHM0WI DN N-(3-(5-methoxy-2-propoxyphenyl)propyl)acetamide DMHM0WI MI TT0WAIE DMHM0WI MN Melatonin receptor type 1A (MTNR1A) DMHM0WI MT DTT DMHM0WI MA Inhibitor DMHM0WI RN Synthesis of substituted N-[3-(3-methoxyphenyl)propyl] amides as highly potent MT(2)-selective melatonin ligands. Bioorg Med Chem Lett. 2010 Apr 15;20(8):2582-5. DMHM0WI RU https://pubmed.ncbi.nlm.nih.gov/20227878 DMHM0WI DI DMHM0WI DMHM0WI DN N-(3-(5-methoxy-2-propoxyphenyl)propyl)acetamide DMHM0WI MI TT32JK8 DMHM0WI MN Melatonin receptor type 1B (MTNR1B) DMHM0WI MT DTT DMHM0WI MA Inhibitor DMHM0WI RN Synthesis of substituted N-[3-(3-methoxyphenyl)propyl] amides as highly potent MT(2)-selective melatonin ligands. Bioorg Med Chem Lett. 2010 Apr 15;20(8):2582-5. DMHM0WI RU https://pubmed.ncbi.nlm.nih.gov/20227878 DMSC862 DI DMSC862 DMSC862 DN N-(3-(aminomethyl)phenyl)benzenesulfonamide DMSC862 MI TTJS8PY DMSC862 MN 5-HT 6 receptor (HTR6) DMSC862 MT DTT DMSC862 MA Inhibitor DMSC862 RN Binding of sulfonyl-containing arylalkylamines at human 5-HT6 serotonin receptors. J Med Chem. 2006 Aug 24;49(17):5217-25. DMSC862 RU https://pubmed.ncbi.nlm.nih.gov/16913710 DMSJX1H DI DMSJX1H DMSJX1H DN N-(3-(phenylthio)pyridin-4-yl)methanesulfonamide DMSJX1H MI TT8NGED DMSJX1H MN Prostaglandin G/H synthase 1 (COX-1) DMSJX1H MT DTT DMSJX1H MA Inhibitor DMSJX1H RN Pyridine analogues of nimesulide: design, synthesis, and in vitro and in vivo pharmacological evaluation as promising cyclooxygenase 1 and 2 inhibi... J Med Chem. 2009 Oct 8;52(19):5864-71. DMSJX1H RU https://pubmed.ncbi.nlm.nih.gov/19791801 DMSJX1H DI DMSJX1H DMSJX1H DN N-(3-(phenylthio)pyridin-4-yl)methanesulfonamide DMSJX1H MI TTVKILB DMSJX1H MN Prostaglandin G/H synthase 2 (COX-2) DMSJX1H MT DTT DMSJX1H MA Inhibitor DMSJX1H RN Pyridine analogues of nimesulide: design, synthesis, and in vitro and in vivo pharmacological evaluation as promising cyclooxygenase 1 and 2 inhibi... J Med Chem. 2009 Oct 8;52(19):5864-71. DMSJX1H RU https://pubmed.ncbi.nlm.nih.gov/19791801 DM6UC8Y DI DM6UC8Y DM6UC8Y DN N-(3-(trifluoromethoxy)benzyl)-4-phenoxybenzamide DM6UC8Y MI TTQBR95 DM6UC8Y MN Stress-activated protein kinase 2a (p38 alpha) DM6UC8Y MT DTT DM6UC8Y MA Inhibitor DM6UC8Y RN Two classes of p38alpha MAP kinase inhibitors having a common diphenylether core but exhibiting divergent binding modes. Bioorg Med Chem Lett. 2005 Dec 1;15(23):5274-9. DM6UC8Y RU https://pubmed.ncbi.nlm.nih.gov/16169718 DMSMRF9 DI DMSMRF9 DMSMRF9 DN N-(3-(trifluoromethyl)benzyl)-4-phenoxybenzamide DMSMRF9 MI TTQBR95 DMSMRF9 MN Stress-activated protein kinase 2a (p38 alpha) DMSMRF9 MT DTT DMSMRF9 MA Inhibitor DMSMRF9 RN Two classes of p38alpha MAP kinase inhibitors having a common diphenylether core but exhibiting divergent binding modes. Bioorg Med Chem Lett. 2005 Dec 1;15(23):5274-9. DMSMRF9 RU https://pubmed.ncbi.nlm.nih.gov/16169718 DM2Y5AP DI DM2Y5AP DM2Y5AP DN N-(3,3-Dimethyl-butyl)-4-hexyloxy-benzamide DM2Y5AP MI TT846HF DM2Y5AP MN Voltage-gated potassium channel Kv7.1 (KCNQ1) DM2Y5AP MT DTT DM2Y5AP MA Inhibitor DM2Y5AP RN Design and synthesis of 4-substituted benzamides as potent, selective, and orally bioavailable I(Ks) blockers. J Med Chem. 2001 Nov 8;44(23):3764-7. DM2Y5AP RU https://pubmed.ncbi.nlm.nih.gov/11689063 DMEUXOQ DI DMEUXOQ DMEUXOQ DN N-(3,3-Dimethyl-butyl)-4-indol-1-yl-benzamide DMEUXOQ MI TT846HF DMEUXOQ MN Voltage-gated potassium channel Kv7.1 (KCNQ1) DMEUXOQ MT DTT DMEUXOQ MA Inhibitor DMEUXOQ RN Design and synthesis of 4-substituted benzamides as potent, selective, and orally bioavailable I(Ks) blockers. J Med Chem. 2001 Nov 8;44(23):3764-7. DMEUXOQ RU https://pubmed.ncbi.nlm.nih.gov/11689063 DM6EJQ4 DI DM6EJQ4 DM6EJQ4 DN N-(3,3-Dimethyl-cyclopentyl)-4-hexyloxy-benzamide DM6EJQ4 MI TT846HF DM6EJQ4 MN Voltage-gated potassium channel Kv7.1 (KCNQ1) DM6EJQ4 MT DTT DM6EJQ4 MA Inhibitor DM6EJQ4 RN Design and synthesis of 4-substituted benzamides as potent, selective, and orally bioavailable I(Ks) blockers. J Med Chem. 2001 Nov 8;44(23):3764-7. DM6EJQ4 RU https://pubmed.ncbi.nlm.nih.gov/11689063 DMAXLVQ DI DMAXLVQ DMAXLVQ DN N-(3,3-Diphenyl)propyl-2,2-diphenylacetamide DMAXLVQ MI TT6OEDT DMAXLVQ MN Cannabinoid receptor 1 (CB1) DMAXLVQ MT DTT DMAXLVQ MA Inhibitor DMAXLVQ RN Novel sterically hindered cannabinoid CB1 receptor ligands. Bioorg Med Chem. 2008 Aug 1;16(15):7510-5. DMAXLVQ RU https://pubmed.ncbi.nlm.nih.gov/18579386 DMAXLVQ DI DMAXLVQ DMAXLVQ DN N-(3,3-Diphenyl)propyl-2,2-diphenylacetamide DMAXLVQ MI TTMSFAW DMAXLVQ MN Cannabinoid receptor 2 (CB2) DMAXLVQ MT DTT DMAXLVQ MA Inhibitor DMAXLVQ RN Novel sterically hindered cannabinoid CB1 receptor ligands. Bioorg Med Chem. 2008 Aug 1;16(15):7510-5. DMAXLVQ RU https://pubmed.ncbi.nlm.nih.gov/18579386 DMBX0K1 DI DMBX0K1 DMBX0K1 DN N-(3,3-Diphenyl)propyl-2-phenylacetamide DMBX0K1 MI TT6OEDT DMBX0K1 MN Cannabinoid receptor 1 (CB1) DMBX0K1 MT DTT DMBX0K1 MA Inhibitor DMBX0K1 RN Novel sterically hindered cannabinoid CB1 receptor ligands. Bioorg Med Chem. 2008 Aug 1;16(15):7510-5. DMBX0K1 RU https://pubmed.ncbi.nlm.nih.gov/18579386 DM4PTR3 DI DM4PTR3 DM4PTR3 DN N-(3,3-Diphenyl-propyl)-2-pyridine-3-ylacetamide DM4PTR3 MI TT7WVHI DM4PTR3 MN Soluble epoxide hydrolase (EPHX2) DM4PTR3 MT DTT DM4PTR3 MA Inhibitor DM4PTR3 RN Structure-based optimization of arylamides as inhibitors of soluble epoxide hydrolase. J Med Chem. 2009 Oct 8;52(19):5880-95. DM4PTR3 RU https://pubmed.ncbi.nlm.nih.gov/19746975 DMOXR4K DI DMOXR4K DMOXR4K DN N-(3,3-Diphenyl-propyl)-isonicotinamide DMOXR4K MI TT7WVHI DMOXR4K MN Soluble epoxide hydrolase (EPHX2) DMOXR4K MT DTT DMOXR4K MA Inhibitor DMOXR4K RN Structure-based optimization of arylamides as inhibitors of soluble epoxide hydrolase. J Med Chem. 2009 Oct 8;52(19):5880-95. DMOXR4K RU https://pubmed.ncbi.nlm.nih.gov/19746975 DMDYZ9K DI DMDYZ9K DMDYZ9K DN N-(3,3-diphenyl-propyl)-nicotinamide DMDYZ9K MI TT7WVHI DMDYZ9K MN Soluble epoxide hydrolase (EPHX2) DMDYZ9K MT DTT DMDYZ9K MA Inhibitor DMDYZ9K RN Structure-based optimization of arylamides as inhibitors of soluble epoxide hydrolase. J Med Chem. 2009 Oct 8;52(19):5880-95. DMDYZ9K RU https://pubmed.ncbi.nlm.nih.gov/19746975 DMQ5USA DI DMQ5USA DMQ5USA DN N-(3,4,5-trihydroxyphenethyl)oleamide DMQ5USA MI TTIQSC1 DMQ5USA MN Bacterial Lethal factor (Bact lef) DMQ5USA MT DTT DMQ5USA MA Inhibitor DMQ5USA RN Inhibitors of anthrax lethal factor. Bioorg Med Chem Lett. 2007 Aug 15;17(16):4575-8. DMQ5USA RU https://pubmed.ncbi.nlm.nih.gov/17574849 DMTERF6 DI DMTERF6 DMTERF6 DN N-(3,4-Dichlorophenyl)propyl-ETAV DMTERF6 MI TT9PB26 DMTERF6 MN Presynaptic density protein 95 (DLG4) DMTERF6 MT DTT DMTERF6 MA Inhibitor DMTERF6 RN Modified peptides as potent inhibitors of the postsynaptic density-95/N-methyl-D-aspartate receptor interaction. J Med Chem. 2008 Oct 23;51(20):6450-9. DMTERF6 RU https://pubmed.ncbi.nlm.nih.gov/18811137 DMF2D4O DI DMF2D4O DMF2D4O DN N-(3,4-Difluorophenyl)propyl-ETAV DMF2D4O MI TT9PB26 DMF2D4O MN Presynaptic density protein 95 (DLG4) DMF2D4O MT DTT DMF2D4O MA Inhibitor DMF2D4O RN Modified peptides as potent inhibitors of the postsynaptic density-95/N-methyl-D-aspartate receptor interaction. J Med Chem. 2008 Oct 23;51(20):6450-9. DMF2D4O RU https://pubmed.ncbi.nlm.nih.gov/18811137 DM67XSW DI DM67XSW DM67XSW DN N-(3,4-dihydroxybenzyl)oleamide DM67XSW MI TTIQSC1 DM67XSW MN Bacterial Lethal factor (Bact lef) DM67XSW MT DTT DM67XSW MA Inhibitor DM67XSW RN Inhibitors of anthrax lethal factor based upon N-oleoyldopamine. Bioorg Med Chem Lett. 2008 Apr 1;18(7):2467-70. DM67XSW RU https://pubmed.ncbi.nlm.nih.gov/18314330 DMEP2VM DI DMEP2VM DMEP2VM DN N-(3,4-Dimethylphenyl)-N'-hydroxyoctanediamide DMEP2VM MI TTBH0VX DMEP2VM MN Histone deacetylase (HDAC) DMEP2VM MT DTT DMEP2VM MA Inhibitor DMEP2VM RN Biological and biophysical properties of the histone deacetylase inhibitor suberoylanilide hydroxamic acid are affected by the presence of short al... J Med Chem. 2010 Mar 11;53(5):1937-50. DMEP2VM RU https://pubmed.ncbi.nlm.nih.gov/20143840 DMEP2VM DI DMEP2VM DMEP2VM DN N-(3,4-Dimethylphenyl)-N'-hydroxyoctanediamide DMEP2VM MI TT6R7JZ DMEP2VM MN Histone deacetylase 1 (HDAC1) DMEP2VM MT DTT DMEP2VM MA Inhibitor DMEP2VM RN Biological and biophysical properties of the histone deacetylase inhibitor suberoylanilide hydroxamic acid are affected by the presence of short al... J Med Chem. 2010 Mar 11;53(5):1937-50. DMEP2VM RU https://pubmed.ncbi.nlm.nih.gov/20143840 DM9B1ID DI DM9B1ID DM9B1ID DN N-(3,5-dichlorophenyl)-2-methyl-3-nitrobenzamide DM9B1ID MI TT3PQ2Y DM9B1ID MN Plasmodium Dihydroorotate dehydrogenase (Malaria DHOdehase) DM9B1ID MT DTT DM9B1ID MA Inhibitor DM9B1ID RN Design and synthesis of potent inhibitors of the malaria parasite dihydroorotate dehydrogenase. J Med Chem. 2007 Jan 25;50(2):186-91. DM9B1ID RU https://pubmed.ncbi.nlm.nih.gov/17228860 DMDNUCL DI DMDNUCL DMDNUCL DN N-(3,5-dichlorophenyl)-2-nitrobenzamide DMDNUCL MI TTVTX4N DMDNUCL MN Bacterial Fatty acid synthetase I (Bact inhA) DMDNUCL MT DTT DMDNUCL MA Inhibitor DMDNUCL RN Discovery of potential new InhA direct inhibitors based on pharmacophore and 3D-QSAR analysis followed by in silico screening. Eur J Med Chem. 2009 Sep;44(9):3718-30. DMDNUCL RU https://pubmed.ncbi.nlm.nih.gov/19428156 DM8DAGL DI DM8DAGL DM8DAGL DN N-(3,5-dichlorophenyl)-4-methoxy-3-nitrobenzamide DM8DAGL MI TTVTX4N DM8DAGL MN Bacterial Fatty acid synthetase I (Bact inhA) DM8DAGL MT DTT DM8DAGL MA Inhibitor DM8DAGL RN Discovery of potential new InhA direct inhibitors based on pharmacophore and 3D-QSAR analysis followed by in silico screening. Eur J Med Chem. 2009 Sep;44(9):3718-30. DM8DAGL RU https://pubmed.ncbi.nlm.nih.gov/19428156 DMQ0LF2 DI DMQ0LF2 DMQ0LF2 DN N-(3,5-dichlorophenyl)imidodicarbonimidic diamide DMQ0LF2 MI TTT1R2L DMQ0LF2 MN Integrin alpha-V (ITGAV) DMQ0LF2 MT DTT DMQ0LF2 MA Inhibitor DMQ0LF2 RN Emerging targets in osteoporosis disease modification. J Med Chem. 2010 Jun 10;53(11):4332-53. DMQ0LF2 RU https://pubmed.ncbi.nlm.nih.gov/20218623 DMQ0LF2 DI DMQ0LF2 DMQ0LF2 DN N-(3,5-dichlorophenyl)imidodicarbonimidic diamide DMQ0LF2 MI TTJA1ZO DMQ0LF2 MN ITGB3 messenger RNA (ITGB3 mRNA) DMQ0LF2 MT DTT DMQ0LF2 MA Inhibitor DMQ0LF2 RN Emerging targets in osteoporosis disease modification. J Med Chem. 2010 Jun 10;53(11):4332-53. DMQ0LF2 RU https://pubmed.ncbi.nlm.nih.gov/20218623 DM95SJU DI DM95SJU DM95SJU DN N-(3,5-dimethoxyphenethyl)docos-13-enamide DM95SJU MI TT6OEDT DM95SJU MN Cannabinoid receptor 1 (CB1) DM95SJU MT DTT DM95SJU MA Inhibitor DM95SJU RN New metabolically stable fatty acid amide ligands of cannabinoid receptors: Synthesis and receptor affinity studies. Bioorg Med Chem Lett. 2006 Jan 1;16(1):138-41. DM95SJU RU https://pubmed.ncbi.nlm.nih.gov/16213718 DM1C40H DI DM1C40H DM1C40H DN N-(3,5-dimethoxyphenethyl)oleamide DM1C40H MI TT6OEDT DM1C40H MN Cannabinoid receptor 1 (CB1) DM1C40H MT DTT DM1C40H MA Inhibitor DM1C40H RN New metabolically stable fatty acid amide ligands of cannabinoid receptors: Synthesis and receptor affinity studies. Bioorg Med Chem Lett. 2006 Jan 1;16(1):138-41. DM1C40H RU https://pubmed.ncbi.nlm.nih.gov/16213718 DM43QHV DI DM43QHV DM43QHV DN N-(3,5-dimethoxyphenyl)-4-methyl-2-nitrobenzamide DM43QHV MI TTVTX4N DM43QHV MN Bacterial Fatty acid synthetase I (Bact inhA) DM43QHV MT DTT DM43QHV MA Inhibitor DM43QHV RN Discovery of potential new InhA direct inhibitors based on pharmacophore and 3D-QSAR analysis followed by in silico screening. Eur J Med Chem. 2009 Sep;44(9):3718-30. DM43QHV RU https://pubmed.ncbi.nlm.nih.gov/19428156 DM1L3FM DI DM1L3FM DM1L3FM DN N-(3,5-Dimethylphenyl)-N'-hydroxyoctanediamide DM1L3FM MI TTBH0VX DM1L3FM MN Histone deacetylase (HDAC) DM1L3FM MT DTT DM1L3FM MA Inhibitor DM1L3FM RN Biological and biophysical properties of the histone deacetylase inhibitor suberoylanilide hydroxamic acid are affected by the presence of short al... J Med Chem. 2010 Mar 11;53(5):1937-50. DM1L3FM RU https://pubmed.ncbi.nlm.nih.gov/20143840 DM1L3FM DI DM1L3FM DM1L3FM DN N-(3,5-Dimethylphenyl)-N'-hydroxyoctanediamide DM1L3FM MI TT6R7JZ DM1L3FM MN Histone deacetylase 1 (HDAC1) DM1L3FM MT DTT DM1L3FM MA Inhibitor DM1L3FM RN Biological and biophysical properties of the histone deacetylase inhibitor suberoylanilide hydroxamic acid are affected by the presence of short al... J Med Chem. 2010 Mar 11;53(5):1937-50. DM1L3FM RU https://pubmed.ncbi.nlm.nih.gov/20143840 DMH3R21 DI DMH3R21 DMH3R21 DN N-(3-acetamidophenyl)-3-chlorobenzamide DMH3R21 MI TTHS256 DMH3R21 MN Metabotropic glutamate receptor 5 (mGluR5) DMH3R21 MT DTT DMH3R21 MA Inhibitor DMH3R21 RN Synthesis and SAR of novel, non-MPEP chemotype mGluR5 NAMs identified by functional HTS. Bioorg Med Chem Lett. 2009 Dec 1;19(23):6502-6. DMH3R21 RU https://pubmed.ncbi.nlm.nih.gov/19875287 DMYJB1A DI DMYJB1A DMYJB1A DN N-(3'-acetyl-4-aminobiphenyl-3-yl)benzamide DMYJB1A MI TTSHTOI DMYJB1A MN Histone deacetylase 2 (HDAC2) DMYJB1A MT DTT DMYJB1A MA Inhibitor DMYJB1A RN Exploration of the HDAC2 foot pocket: Synthesis and SAR of substituted N-(2-aminophenyl)benzamides. Bioorg Med Chem Lett. 2010 May 15;20(10):3142-5. DMYJB1A RU https://pubmed.ncbi.nlm.nih.gov/20392638 DMJ6FP7 DI DMJ6FP7 DMJ6FP7 DN N-(3-aminophenyl)benzenesulfonamide DMJ6FP7 MI TTJS8PY DMJ6FP7 MN 5-HT 6 receptor (HTR6) DMJ6FP7 MT DTT DMJ6FP7 MA Inhibitor DMJ6FP7 RN Binding of sulfonyl-containing arylalkylamines at human 5-HT6 serotonin receptors. J Med Chem. 2006 Aug 24;49(17):5217-25. DMJ6FP7 RU https://pubmed.ncbi.nlm.nih.gov/16913710 DMYSURL DI DMYSURL DMYSURL DN N-(3-Benzooxazol-7-yl-propyl)-acetamide DMYSURL MI TT32JK8 DMYSURL MN Melatonin receptor type 1B (MTNR1B) DMYSURL MT DTT DMYSURL MA Inhibitor DMYSURL RN Synthesis and structure-activity relationship of novel benzoxazole derivatives as melatonin receptor agonists. Bioorg Med Chem Lett. 2004 Jul 16;14(14):3799-802. DMYSURL RU https://pubmed.ncbi.nlm.nih.gov/15203165 DMKMESD DI DMKMESD DMKMESD DN N-(3-Benzooxazol-7-yl-propyl)-butyramide DMKMESD MI TT32JK8 DMKMESD MN Melatonin receptor type 1B (MTNR1B) DMKMESD MT DTT DMKMESD MA Inhibitor DMKMESD RN Synthesis and structure-activity relationship of novel benzoxazole derivatives as melatonin receptor agonists. Bioorg Med Chem Lett. 2004 Jul 16;14(14):3799-802. DMKMESD RU https://pubmed.ncbi.nlm.nih.gov/15203165 DMEMYS1 DI DMEMYS1 DMEMYS1 DN N-(3-Benzooxazol-7-yl-propyl)-propionamide DMEMYS1 MI TT32JK8 DMEMYS1 MN Melatonin receptor type 1B (MTNR1B) DMEMYS1 MT DTT DMEMYS1 MA Inhibitor DMEMYS1 RN Synthesis and structure-activity relationship of novel benzoxazole derivatives as melatonin receptor agonists. Bioorg Med Chem Lett. 2004 Jul 16;14(14):3799-802. DMEMYS1 RU https://pubmed.ncbi.nlm.nih.gov/15203165 DMOQ08F DI DMOQ08F DMOQ08F DN N-(3-Bromo-benzoyl)-4-chloro-benzenesulfonamide DMOQ08F MI TTUTJGQ DMOQ08F MN Vascular endothelial growth factor receptor 2 (KDR) DMOQ08F MT DTT DMOQ08F MA Inhibitor DMOQ08F RN Acyl sulfonamide anti-proliferatives: benzene substituent structure-activity relationships for a novel class of antitumor agents. J Med Chem. 2004 Oct 21;47(22):5367-80. DMOQ08F RU https://pubmed.ncbi.nlm.nih.gov/15481975 DMOQ08F DI DMOQ08F DMOQ08F DN N-(3-Bromo-benzoyl)-4-chloro-benzenesulfonamide DMOQ08F MI TTDCBX5 DMOQ08F MN Vascular endothelial growth factor receptor 3 (FLT-4) DMOQ08F MT DTT DMOQ08F MA Inhibitor DMOQ08F RN Acyl sulfonamide anti-proliferatives: benzene substituent structure-activity relationships for a novel class of antitumor agents. J Med Chem. 2004 Oct 21;47(22):5367-80. DMOQ08F RU https://pubmed.ncbi.nlm.nih.gov/15481975 DMOQ08F DI DMOQ08F DMOQ08F DN N-(3-Bromo-benzoyl)-4-chloro-benzenesulfonamide DMOQ08F MI TT1VAUK DMOQ08F MN VEGFR1 messenger RNA (VEGFR1 mRNA) DMOQ08F MT DTT DMOQ08F MA Inhibitor DMOQ08F RN Acyl sulfonamide anti-proliferatives: benzene substituent structure-activity relationships for a novel class of antitumor agents. J Med Chem. 2004 Oct 21;47(22):5367-80. DMOQ08F RU https://pubmed.ncbi.nlm.nih.gov/15481975 DM0Z1HJ DI DM0Z1HJ DM0Z1HJ DN N-(3-Bromophenyl)-5-methoxybenzo[d]oxazol-2-amine DM0Z1HJ MI TT2J34L DM0Z1HJ MN Arachidonate 5-lipoxygenase (5-LOX) DM0Z1HJ MT DTT DM0Z1HJ MA Inhibitor DM0Z1HJ RN Synthesis and evaluation of benzoxazole derivatives as 5-lipoxygenase inhibitors. Bioorg Med Chem. 2010 Nov 1;18(21):7580-5. DM0Z1HJ RU https://pubmed.ncbi.nlm.nih.gov/20870413 DMEWQCN DI DMEWQCN DMEWQCN DN N-(3-bromophenyl)-6-chloroquinazolin-4-amine DMEWQCN MI TTVBPDM DMEWQCN MN Metabotropic glutamate receptor 1 (mGluR1) DMEWQCN MT DTT DMEWQCN MA Inhibitor DMEWQCN RN Discovery and SAR of 6-substituted-4-anilinoquinazolines as non-competitive antagonists of mGlu5. Bioorg Med Chem Lett. 2009 Dec 1;19(23):6623-6. DMEWQCN RU https://pubmed.ncbi.nlm.nih.gov/19854049 DMEWQCN DI DMEWQCN DMEWQCN DN N-(3-bromophenyl)-6-chloroquinazolin-4-amine DMEWQCN MI TTHS256 DMEWQCN MN Metabotropic glutamate receptor 5 (mGluR5) DMEWQCN MT DTT DMEWQCN MA Inhibitor DMEWQCN RN Discovery and SAR of 6-substituted-4-anilinoquinazolines as non-competitive antagonists of mGlu5. Bioorg Med Chem Lett. 2009 Dec 1;19(23):6623-6. DMEWQCN RU https://pubmed.ncbi.nlm.nih.gov/19854049 DMRIK7P DI DMRIK7P DMRIK7P DN N-(3-bromophenyl)-6-fluoroquinazolin-4-amine DMRIK7P MI TTVBPDM DMRIK7P MN Metabotropic glutamate receptor 1 (mGluR1) DMRIK7P MT DTT DMRIK7P MA Inhibitor DMRIK7P RN Discovery and SAR of 6-substituted-4-anilinoquinazolines as non-competitive antagonists of mGlu5. Bioorg Med Chem Lett. 2009 Dec 1;19(23):6623-6. DMRIK7P RU https://pubmed.ncbi.nlm.nih.gov/19854049 DMRIK7P DI DMRIK7P DMRIK7P DN N-(3-bromophenyl)-6-fluoroquinazolin-4-amine DMRIK7P MI TTHS256 DMRIK7P MN Metabotropic glutamate receptor 5 (mGluR5) DMRIK7P MT DTT DMRIK7P MA Inhibitor DMRIK7P RN Discovery and SAR of 6-substituted-4-anilinoquinazolines as non-competitive antagonists of mGlu5. Bioorg Med Chem Lett. 2009 Dec 1;19(23):6623-6. DMRIK7P RU https://pubmed.ncbi.nlm.nih.gov/19854049 DME6IKT DI DME6IKT DME6IKT DN N-(3-Chloro-phenyl)-2-cyclohexyl-acetamide DME6IKT MI TT7WVHI DME6IKT MN Soluble epoxide hydrolase (EPHX2) DME6IKT MT DTT DME6IKT MA Inhibitor DME6IKT RN Optimization of amide-based inhibitors of soluble epoxide hydrolase with improved water solubility. J Med Chem. 2005 May 19;48(10):3621-9. DME6IKT RU https://pubmed.ncbi.nlm.nih.gov/15887969 DM3RQHG DI DM3RQHG DM3RQHG DN N-(3-chlorophenyl)-3-cyano-5-fluorobenzamide DM3RQHG MI TTHS256 DM3RQHG MN Metabotropic glutamate receptor 5 (mGluR5) DM3RQHG MT DTT DM3RQHG MA Inhibitor DM3RQHG RN 3-Cyano-5-fluoro-N-arylbenzamides as negative allosteric modulators of mGlu(5): Identification of easily prepared tool compounds with CNS exposure ... Bioorg Med Chem Lett. 2010 Aug 1;20(15):4390-4. DM3RQHG RU https://pubmed.ncbi.nlm.nih.gov/20598884 DM3AGJH DI DM3AGJH DM3AGJH DN N-(3-chlorophenyl)-6-fluoroquinazolin-4-amine DM3AGJH MI TTHS256 DM3AGJH MN Metabotropic glutamate receptor 5 (mGluR5) DM3AGJH MT DTT DM3AGJH MA Inhibitor DM3AGJH RN Discovery and SAR of 6-substituted-4-anilinoquinazolines as non-competitive antagonists of mGlu5. Bioorg Med Chem Lett. 2009 Dec 1;19(23):6623-6. DM3AGJH RU https://pubmed.ncbi.nlm.nih.gov/19854049 DMQEPV0 DI DMQEPV0 DMQEPV0 DN N-(3-chlorophenyl)-6-methoxyquinazolin-4-amine DMQEPV0 MI TTHS256 DMQEPV0 MN Metabotropic glutamate receptor 5 (mGluR5) DMQEPV0 MT DTT DMQEPV0 MA Inhibitor DMQEPV0 RN Discovery and SAR of 6-substituted-4-anilinoquinazolines as non-competitive antagonists of mGlu5. Bioorg Med Chem Lett. 2009 Dec 1;19(23):6623-6. DMQEPV0 RU https://pubmed.ncbi.nlm.nih.gov/19854049 DMIKP5Y DI DMIKP5Y DMIKP5Y DN N-(3-chlorophenyl)-6-nitroquinazolin-4-amine DMIKP5Y MI TTHS256 DMIKP5Y MN Metabotropic glutamate receptor 5 (mGluR5) DMIKP5Y MT DTT DMIKP5Y MA Inhibitor DMIKP5Y RN Discovery and SAR of 6-substituted-4-anilinoquinazolines as non-competitive antagonists of mGlu5. Bioorg Med Chem Lett. 2009 Dec 1;19(23):6623-6. DMIKP5Y RU https://pubmed.ncbi.nlm.nih.gov/19854049 DMC5G6Y DI DMC5G6Y DMC5G6Y DN N-(3-Ethylphenyl)-N'-hydroxyoctanediamide DMC5G6Y MI TTBH0VX DMC5G6Y MN Histone deacetylase (HDAC) DMC5G6Y MT DTT DMC5G6Y MA Inhibitor DMC5G6Y RN Biological and biophysical properties of the histone deacetylase inhibitor suberoylanilide hydroxamic acid are affected by the presence of short al... J Med Chem. 2010 Mar 11;53(5):1937-50. DMC5G6Y RU https://pubmed.ncbi.nlm.nih.gov/20143840 DMC5G6Y DI DMC5G6Y DMC5G6Y DN N-(3-Ethylphenyl)-N'-hydroxyoctanediamide DMC5G6Y MI TT6R7JZ DMC5G6Y MN Histone deacetylase 1 (HDAC1) DMC5G6Y MT DTT DMC5G6Y MA Inhibitor DMC5G6Y RN Biological and biophysical properties of the histone deacetylase inhibitor suberoylanilide hydroxamic acid are affected by the presence of short al... J Med Chem. 2010 Mar 11;53(5):1937-50. DMC5G6Y RU https://pubmed.ncbi.nlm.nih.gov/20143840 DM0H8CK DI DM0H8CK DM0H8CK DN N-(3-Methanesulfonyl-4-methoxy-benzoyl)-guanidine DM0H8CK MI TTGSEFH DM0H8CK MN Sodium/hydrogen exchanger 1 (SLC9A1) DM0H8CK MT DTT DM0H8CK MA Inhibitor DM0H8CK RN (2-Methyl-5-(methylsulfonyl)benzoyl)guanidine Na+/H+ antiporter inhibitors. J Med Chem. 1997 Jun 20;40(13):2017-34. DM0H8CK RU https://pubmed.ncbi.nlm.nih.gov/9207943 DM0H8CK DI DM0H8CK DM0H8CK DN N-(3-Methanesulfonyl-4-methoxy-benzoyl)-guanidine DM0H8CK MI TTFZVPO DM0H8CK MN Sodium/hydrogen exchanger 3 (SLC9A3) DM0H8CK MT DTT DM0H8CK MA Inhibitor DM0H8CK RN (2-Methyl-5-(methylsulfonyl)benzoyl)guanidine Na+/H+ antiporter inhibitors. J Med Chem. 1997 Jun 20;40(13):2017-34. DM0H8CK RU https://pubmed.ncbi.nlm.nih.gov/9207943 DMSVQJP DI DMSVQJP DMSVQJP DN N-(3-Methanesulfonyl-4-methyl-benzoyl)-guanidine DMSVQJP MI TTGSEFH DMSVQJP MN Sodium/hydrogen exchanger 1 (SLC9A1) DMSVQJP MT DTT DMSVQJP MA Inhibitor DMSVQJP RN (2-Methyl-5-(methylsulfonyl)benzoyl)guanidine Na+/H+ antiporter inhibitors. J Med Chem. 1997 Jun 20;40(13):2017-34. DMSVQJP RU https://pubmed.ncbi.nlm.nih.gov/9207943 DMSVQJP DI DMSVQJP DMSVQJP DN N-(3-Methanesulfonyl-4-methyl-benzoyl)-guanidine DMSVQJP MI TTFZVPO DMSVQJP MN Sodium/hydrogen exchanger 3 (SLC9A3) DMSVQJP MT DTT DMSVQJP MA Inhibitor DMSVQJP RN (2-Methyl-5-(methylsulfonyl)benzoyl)guanidine Na+/H+ antiporter inhibitors. J Med Chem. 1997 Jun 20;40(13):2017-34. DMSVQJP RU https://pubmed.ncbi.nlm.nih.gov/9207943 DM2D4KY DI DM2D4KY DM2D4KY DN N-(3-METHYLBUT-2-EN-1-YL)-9H-PURIN-6-AMINE DM2D4KY MI TT7HF4W DM2D4KY MN Cyclin-dependent kinase 2 (CDK2) DM2D4KY MT DTT DM2D4KY MA Inhibitor DM2D4KY RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DM2D4KY RU https://pubmed.ncbi.nlm.nih.gov/10592235 DMHZU8K DI DMHZU8K DMHZU8K DN N-(3-phenethoxybenzyl)-4-hydroxybenzamide DMHZU8K MI TTN9D8E DMHZU8K MN Glutamate receptor ionotropic NMDA 2B (NMDAR2B) DMHZU8K MT DTT DMHZU8K MA Inhibitor DMHZU8K RN Structure-activity relationship study of novel NR2B-selective antagonists with arylamides to avoid reactive metabolites formation. Bioorg Med Chem Lett. 2007 Oct 15;17(20):5537-42. DMHZU8K RU https://pubmed.ncbi.nlm.nih.gov/17766107 DMXF46V DI DMXF46V DMXF46V DN N-(3-phenoxy-4-pyridinyl)ethanesulfonamide DMXF46V MI TT8NGED DMXF46V MN Prostaglandin G/H synthase 1 (COX-1) DMXF46V MT DTT DMXF46V MA Inhibitor DMXF46V RN Design, synthesis, and pharmacological evaluation of pyridinic analogues of nimesulide as cyclooxygenase-2 selective inhibitors. J Med Chem. 2004 Dec 30;47(27):6749-59. DMXF46V RU https://pubmed.ncbi.nlm.nih.gov/15615524 DMXF46V DI DMXF46V DMXF46V DN N-(3-phenoxy-4-pyridinyl)ethanesulfonamide DMXF46V MI TTVKILB DMXF46V MN Prostaglandin G/H synthase 2 (COX-2) DMXF46V MT DTT DMXF46V MA Inhibitor DMXF46V RN Design, synthesis, and pharmacological evaluation of pyridinic analogues of nimesulide as cyclooxygenase-2 selective inhibitors. J Med Chem. 2004 Dec 30;47(27):6749-59. DMXF46V RU https://pubmed.ncbi.nlm.nih.gov/15615524 DMN1DPJ DI DMN1DPJ DMN1DPJ DN N-(3-phenoxy-4-pyridinyl)propanesulfonamide DMN1DPJ MI TT8NGED DMN1DPJ MN Prostaglandin G/H synthase 1 (COX-1) DMN1DPJ MT DTT DMN1DPJ MA Inhibitor DMN1DPJ RN Design, synthesis, and pharmacological evaluation of pyridinic analogues of nimesulide as cyclooxygenase-2 selective inhibitors. J Med Chem. 2004 Dec 30;47(27):6749-59. DMN1DPJ RU https://pubmed.ncbi.nlm.nih.gov/15615524 DM7CM3F DI DM7CM3F DM7CM3F DN N-(3-phenoxypyridin-4-yl)methanesulfonamide DM7CM3F MI TT8NGED DM7CM3F MN Prostaglandin G/H synthase 1 (COX-1) DM7CM3F MT DTT DM7CM3F MA Inhibitor DM7CM3F RN Pyridine analogues of nimesulide: design, synthesis, and in vitro and in vivo pharmacological evaluation as promising cyclooxygenase 1 and 2 inhibi... J Med Chem. 2009 Oct 8;52(19):5864-71. DM7CM3F RU https://pubmed.ncbi.nlm.nih.gov/19791801 DMSNF7W DI DMSNF7W DMSNF7W DN N-(3-Phenyl)propyl-2-(4-bromophenylacetamide) DMSNF7W MI TT6OEDT DMSNF7W MN Cannabinoid receptor 1 (CB1) DMSNF7W MT DTT DMSNF7W MA Inhibitor DMSNF7W RN Novel sterically hindered cannabinoid CB1 receptor ligands. Bioorg Med Chem. 2008 Aug 1;16(15):7510-5. DMSNF7W RU https://pubmed.ncbi.nlm.nih.gov/18579386 DMSNF7W DI DMSNF7W DMSNF7W DN N-(3-Phenyl)propyl-2-(4-bromophenylacetamide) DMSNF7W MI TTMSFAW DMSNF7W MN Cannabinoid receptor 2 (CB2) DMSNF7W MT DTT DMSNF7W MA Inhibitor DMSNF7W RN Novel sterically hindered cannabinoid CB1 receptor ligands. Bioorg Med Chem. 2008 Aug 1;16(15):7510-5. DMSNF7W RU https://pubmed.ncbi.nlm.nih.gov/18579386 DM9XH18 DI DM9XH18 DM9XH18 DN N-(3-Phenyl)propyl-2,2-diphenylacetamide DM9XH18 MI TT6OEDT DM9XH18 MN Cannabinoid receptor 1 (CB1) DM9XH18 MT DTT DM9XH18 MA Inhibitor DM9XH18 RN Novel sterically hindered cannabinoid CB1 receptor ligands. Bioorg Med Chem. 2008 Aug 1;16(15):7510-5. DM9XH18 RU https://pubmed.ncbi.nlm.nih.gov/18579386 DM4IA92 DI DM4IA92 DM4IA92 DN N-(3-Phenyl-[1,2,4]thiadiazol-5-yl)-benzamide DM4IA92 MI TTM2AOE DM4IA92 MN Adenosine A2a receptor (ADORA2A) DM4IA92 MT DTT DM4IA92 MA Inhibitor DM4IA92 RN Thiazole and thiadiazole analogues as a novel class of adenosine receptor antagonists. J Med Chem. 2001 Mar 1;44(5):749-62. DM4IA92 RU https://pubmed.ncbi.nlm.nih.gov/11262085 DMJB7SE DI DMJB7SE DMJB7SE DN N-(3-phenylamino-4-pyridinyl)methanesulfonamide DMJB7SE MI TT8NGED DMJB7SE MN Prostaglandin G/H synthase 1 (COX-1) DMJB7SE MT DTT DMJB7SE MA Inhibitor DMJB7SE RN Pyridine analogues of nimesulide: design, synthesis, and in vitro and in vivo pharmacological evaluation as promising cyclooxygenase 1 and 2 inhibi... J Med Chem. 2009 Oct 8;52(19):5864-71. DMJB7SE RU https://pubmed.ncbi.nlm.nih.gov/19791801 DMJB7SE DI DMJB7SE DMJB7SE DN N-(3-phenylamino-4-pyridinyl)methanesulfonamide DMJB7SE MI TTVKILB DMJB7SE MN Prostaglandin G/H synthase 2 (COX-2) DMJB7SE MT DTT DMJB7SE MA Inhibitor DMJB7SE RN Pyridine analogues of nimesulide: design, synthesis, and in vitro and in vivo pharmacological evaluation as promising cyclooxygenase 1 and 2 inhibi... J Med Chem. 2009 Oct 8;52(19):5864-71. DMJB7SE RU https://pubmed.ncbi.nlm.nih.gov/19791801 DMKAX3Q DI DMKAX3Q DMKAX3Q DN N-(3-Phenylpropyl)-1H-indole-2-carboxamide DMKAX3Q MI TT3WG5C DMKAX3Q MN Monoamine oxidase type A (MAO-A) DMKAX3Q MT DTT DMKAX3Q MA Inhibitor DMKAX3Q RN Synthesis, structure-activity relationships and molecular modeling studies of new indole inhibitors of monoamine oxidases A and B. Bioorg Med Chem. 2008 Nov 15;16(22):9729-40. DMKAX3Q RU https://pubmed.ncbi.nlm.nih.gov/18951803 DMKAX3Q DI DMKAX3Q DMKAX3Q DN N-(3-Phenylpropyl)-1H-indole-2-carboxamide DMKAX3Q MI TTGP7BY DMKAX3Q MN Monoamine oxidase type B (MAO-B) DMKAX3Q MT DTT DMKAX3Q MA Inhibitor DMKAX3Q RN Synthesis, structure-activity relationships and molecular modeling studies of new indole inhibitors of monoamine oxidases A and B. Bioorg Med Chem. 2008 Nov 15;16(22):9729-40. DMKAX3Q RU https://pubmed.ncbi.nlm.nih.gov/18951803 DMZ3I6U DI DMZ3I6U DMZ3I6U DN N-(3-phenylpropyl)-1H-pyrrole-2-carboxamide DMZ3I6U MI TT3WG5C DMZ3I6U MN Monoamine oxidase type A (MAO-A) DMZ3I6U MT DTT DMZ3I6U MA Inhibitor DMZ3I6U RN New pyrrole inhibitors of monoamine oxidase: synthesis, biological evaluation, and structural determinants of MAO-A and MAO-B selectivity. J Med Chem. 2007 Mar 8;50(5):922-31. DMZ3I6U RU https://pubmed.ncbi.nlm.nih.gov/17256833 DMA7X62 DI DMA7X62 DMA7X62 DN N-(3-Phenyl-propyl)-nicotinamide DMA7X62 MI TT7WVHI DMA7X62 MN Soluble epoxide hydrolase (EPHX2) DMA7X62 MT DTT DMA7X62 MA Inhibitor DMA7X62 RN Structure-based optimization of arylamides as inhibitors of soluble epoxide hydrolase. J Med Chem. 2009 Oct 8;52(19):5880-95. DMA7X62 RU https://pubmed.ncbi.nlm.nih.gov/19746975 DM1V83P DI DM1V83P DM1V83P DN N-(4-(2-aminoethyl)phenyl)benzenesulfonamide DM1V83P MI TTJS8PY DM1V83P MN 5-HT 6 receptor (HTR6) DM1V83P MT DTT DM1V83P MA Inhibitor DM1V83P RN Binding of sulfonyl-containing arylalkylamines at human 5-HT6 serotonin receptors. J Med Chem. 2006 Aug 24;49(17):5217-25. DM1V83P RU https://pubmed.ncbi.nlm.nih.gov/16913710 DMRH987 DI DMRH987 DMRH987 DN N-(4-(3-(pyridin-2-yl)acryloyl)phenyl)acetamide DMRH987 MI TTYFKSZ DMRH987 MN Tubulin beta (TUBB) DMRH987 MT DTT DMRH987 MA Inhibitor DMRH987 RN Design and biological evaluation of novel tubulin inhibitors as antimitotic agents using a pharmacophore binding model with tubulin. J Med Chem. 2006 Sep 21;49(19):5664-70. DMRH987 RU https://pubmed.ncbi.nlm.nih.gov/16970393 DMRH987 DI DMRH987 DMRH987 DN N-(4-(3-(pyridin-2-yl)acryloyl)phenyl)acetamide DMRH987 MI TTJ2PTI DMRH987 MN Tubulin beta-2 chain (TUBB2) DMRH987 MT DTT DMRH987 MA Inhibitor DMRH987 RN Design and biological evaluation of novel tubulin inhibitors as antimitotic agents using a pharmacophore binding model with tubulin. J Med Chem. 2006 Sep 21;49(19):5664-70. DMRH987 RU https://pubmed.ncbi.nlm.nih.gov/16970393 DMQDI5H DI DMQDI5H DMQDI5H DN N-(4-(4-hexyl-2-hydroxyphenoxy)phenyl)acetamide DMQDI5H MI TTVTX4N DMQDI5H MN Bacterial Fatty acid synthetase I (Bact inhA) DMQDI5H MT DTT DMQDI5H MA Inhibitor DMQDI5H RN Synthesis and in vitro antimycobacterial activity of B-ring modified diaryl ether InhA inhibitors. Bioorg Med Chem Lett. 2008 May 15;18(10):3029-33. DMQDI5H RU https://pubmed.ncbi.nlm.nih.gov/18457948 DMIPKNQ DI DMIPKNQ DMIPKNQ DN N-(4-(benzyloxy)phenethyl)pyridin-4-amine DMIPKNQ MI TTN9D8E DMIPKNQ MN Glutamate receptor ionotropic NMDA 2B (NMDAR2B) DMIPKNQ MT DTT DMIPKNQ MA Inhibitor DMIPKNQ RN Identification and characterization of 4-methylbenzyl 4-[(pyrimidin-2-ylamino)methyl]piperidine-1-carboxylate, an orally bioavailable, brain penetr... J Med Chem. 2007 Feb 22;50(4):807-19. DMIPKNQ RU https://pubmed.ncbi.nlm.nih.gov/17249648 DMIPKNQ DI DMIPKNQ DMIPKNQ DN N-(4-(benzyloxy)phenethyl)pyridin-4-amine DMIPKNQ MI TTQ6VDM DMIPKNQ MN Voltage-gated potassium channel Kv11.1 (KCNH2) DMIPKNQ MT DTT DMIPKNQ MA Inhibitor DMIPKNQ RN Identification and characterization of 4-methylbenzyl 4-[(pyrimidin-2-ylamino)methyl]piperidine-1-carboxylate, an orally bioavailable, brain penetr... J Med Chem. 2007 Feb 22;50(4):807-19. DMIPKNQ RU https://pubmed.ncbi.nlm.nih.gov/17249648 DMZAOVG DI DMZAOVG DMZAOVG DN N-(4-(diethylamino)phenyl)-2-nitrobenzamide DMZAOVG MI TTVTX4N DMZAOVG MN Bacterial Fatty acid synthetase I (Bact inhA) DMZAOVG MT DTT DMZAOVG MA Inhibitor DMZAOVG RN Discovery of potential new InhA direct inhibitors based on pharmacophore and 3D-QSAR analysis followed by in silico screening. Eur J Med Chem. 2009 Sep;44(9):3718-30. DMZAOVG RU https://pubmed.ncbi.nlm.nih.gov/19428156 DMI74KM DI DMI74KM DMI74KM DN N-(4-(phenylamino)quinazolin-6-yl)acrylamide DMI74KM MI TTGKNB4 DMI74KM MN Epidermal growth factor receptor (EGFR) DMI74KM MT DTT DMI74KM MA Inhibitor DMI74KM RN Structure-guided development of affinity probes for tyrosine kinases using chemical genetics. Nat Chem Biol. 2007 Apr;3(4):229-38. DMI74KM RU https://pubmed.ncbi.nlm.nih.gov/17334377 DMI74KM DI DMI74KM DMI74KM DN N-(4-(phenylamino)quinazolin-6-yl)acrylamide DMI74KM MI TT6PKBN DMI74KM MN Proto-oncogene c-Src (SRC) DMI74KM MT DTT DMI74KM MA Inhibitor DMI74KM RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DMI74KM RU https://pubmed.ncbi.nlm.nih.gov/10592235 DMZ0V8O DI DMZ0V8O DMZ0V8O DN N-(4-(trifluoromethyl)benzyl)-4-phenoxybenzamide DMZ0V8O MI TTQBR95 DMZ0V8O MN Stress-activated protein kinase 2a (p38 alpha) DMZ0V8O MT DTT DMZ0V8O MA Inhibitor DMZ0V8O RN Two classes of p38alpha MAP kinase inhibitors having a common diphenylether core but exhibiting divergent binding modes. Bioorg Med Chem Lett. 2005 Dec 1;15(23):5274-9. DMZ0V8O RU https://pubmed.ncbi.nlm.nih.gov/16169718 DM086VJ DI DM086VJ DM086VJ DN N-(4,4-Diphenyl-butyl)-nicotinamide DM086VJ MI TT7WVHI DM086VJ MN Soluble epoxide hydrolase (EPHX2) DM086VJ MT DTT DM086VJ MA Inhibitor DM086VJ RN Structure-based optimization of arylamides as inhibitors of soluble epoxide hydrolase. J Med Chem. 2009 Oct 8;52(19):5880-95. DM086VJ RU https://pubmed.ncbi.nlm.nih.gov/19746975 DM34R10 DI DM34R10 DM34R10 DN N-(4,5-diphenylpyrimidin-2-yl)acetamide DM34R10 MI TTK25J1 DM34R10 MN Adenosine A1 receptor (ADORA1) DM34R10 MT DTT DM34R10 MA Inhibitor DM34R10 RN 2,4,6-trisubstituted pyrimidines as a new class of selective adenosine A1 receptor antagonists. J Med Chem. 2004 Dec 16;47(26):6529-40. DM34R10 RU https://pubmed.ncbi.nlm.nih.gov/15588088 DM34R10 DI DM34R10 DM34R10 DN N-(4,5-diphenylpyrimidin-2-yl)acetamide DM34R10 MI TTJFY5U DM34R10 MN Adenosine A3 receptor (ADORA3) DM34R10 MT DTT DM34R10 MA Inhibitor DM34R10 RN 2,4,6-trisubstituted pyrimidines as a new class of selective adenosine A1 receptor antagonists. J Med Chem. 2004 Dec 16;47(26):6529-40. DM34R10 RU https://pubmed.ncbi.nlm.nih.gov/15588088 DMDP1QG DI DMDP1QG DMDP1QG DN N-(4,6-diphenylpyrimidin-2-yl)-2-ethylbutyramide DMDP1QG MI TTK25J1 DMDP1QG MN Adenosine A1 receptor (ADORA1) DMDP1QG MT DTT DMDP1QG MA Inhibitor DMDP1QG RN 2,4,6-trisubstituted pyrimidines as a new class of selective adenosine A1 receptor antagonists. J Med Chem. 2004 Dec 16;47(26):6529-40. DMDP1QG RU https://pubmed.ncbi.nlm.nih.gov/15588088 DMQVPK9 DI DMQVPK9 DMQVPK9 DN N-(4,6-diphenylpyrimidin-2-yl)-3-chlorobenzamide DMQVPK9 MI TTK25J1 DMQVPK9 MN Adenosine A1 receptor (ADORA1) DMQVPK9 MT DTT DMQVPK9 MA Inhibitor DMQVPK9 RN 2,4,6-trisubstituted pyrimidines as a new class of selective adenosine A1 receptor antagonists. J Med Chem. 2004 Dec 16;47(26):6529-40. DMQVPK9 RU https://pubmed.ncbi.nlm.nih.gov/15588088 DMOAPJ1 DI DMOAPJ1 DMOAPJ1 DN N-(4,6-diphenylpyrimidin-2-yl)-3-methylbutyramide DMOAPJ1 MI TTK25J1 DMOAPJ1 MN Adenosine A1 receptor (ADORA1) DMOAPJ1 MT DTT DMOAPJ1 MA Inhibitor DMOAPJ1 RN 2,4,6-trisubstituted pyrimidines as a new class of selective adenosine A1 receptor antagonists. J Med Chem. 2004 Dec 16;47(26):6529-40. DMOAPJ1 RU https://pubmed.ncbi.nlm.nih.gov/15588088 DM1PSR7 DI DM1PSR7 DM1PSR7 DN N-(4,6-diphenylpyrimidin-2-yl)-4-chlorobenzamide DM1PSR7 MI TTJFY5U DM1PSR7 MN Adenosine A3 receptor (ADORA3) DM1PSR7 MT DTT DM1PSR7 MA Inhibitor DM1PSR7 RN 2,4,6-trisubstituted pyrimidines as a new class of selective adenosine A1 receptor antagonists. J Med Chem. 2004 Dec 16;47(26):6529-40. DM1PSR7 RU https://pubmed.ncbi.nlm.nih.gov/15588088 DMA214F DI DMA214F DMA214F DN N-(4,6-diphenylpyrimidin-2-yl)benzamide DMA214F MI TTK25J1 DMA214F MN Adenosine A1 receptor (ADORA1) DMA214F MT DTT DMA214F MA Inhibitor DMA214F RN 2,4,6-trisubstituted pyrimidines as a new class of selective adenosine A1 receptor antagonists. J Med Chem. 2004 Dec 16;47(26):6529-40. DMA214F RU https://pubmed.ncbi.nlm.nih.gov/15588088 DMJZ2IP DI DMJZ2IP DMJZ2IP DN N-(4,6-diphenylpyrimidin-2-yl)propionamide DMJZ2IP MI TTK25J1 DMJZ2IP MN Adenosine A1 receptor (ADORA1) DMJZ2IP MT DTT DMJZ2IP MA Inhibitor DMJZ2IP RN 2,4,6-trisubstituted pyrimidines as a new class of selective adenosine A1 receptor antagonists. J Med Chem. 2004 Dec 16;47(26):6529-40. DMJZ2IP RU https://pubmed.ncbi.nlm.nih.gov/15588088 DMJZ2IP DI DMJZ2IP DMJZ2IP DN N-(4,6-diphenylpyrimidin-2-yl)propionamide DMJZ2IP MI TTM2AOE DMJZ2IP MN Adenosine A2a receptor (ADORA2A) DMJZ2IP MT DTT DMJZ2IP MA Inhibitor DMJZ2IP RN 2,4,6-trisubstituted pyrimidines as a new class of selective adenosine A1 receptor antagonists. J Med Chem. 2004 Dec 16;47(26):6529-40. DMJZ2IP RU https://pubmed.ncbi.nlm.nih.gov/15588088 DMJZ2IP DI DMJZ2IP DMJZ2IP DN N-(4,6-diphenylpyrimidin-2-yl)propionamide DMJZ2IP MI TTJFY5U DMJZ2IP MN Adenosine A3 receptor (ADORA3) DMJZ2IP MT DTT DMJZ2IP MA Inhibitor DMJZ2IP RN 2,4,6-trisubstituted pyrimidines as a new class of selective adenosine A1 receptor antagonists. J Med Chem. 2004 Dec 16;47(26):6529-40. DMJZ2IP RU https://pubmed.ncbi.nlm.nih.gov/15588088 DMIJLX6 DI DMIJLX6 DMIJLX6 DN N-(4'-acetyl-4-aminobiphenyl-3-yl)benzamide DMIJLX6 MI TTSHTOI DMIJLX6 MN Histone deacetylase 2 (HDAC2) DMIJLX6 MT DTT DMIJLX6 MA Inhibitor DMIJLX6 RN Exploration of the HDAC2 foot pocket: Synthesis and SAR of substituted N-(2-aminophenyl)benzamides. Bioorg Med Chem Lett. 2010 May 15;20(10):3142-5. DMIJLX6 RU https://pubmed.ncbi.nlm.nih.gov/20392638 DMCLRBK DI DMCLRBK DMCLRBK DN N-(4-amino-2-propylquinolin-6-yl)cinnamamide DMCLRBK MI TTX4RTB DMCLRBK MN Melanin-concentrating hormone receptor 1 (MCHR1) DMCLRBK MT DTT DMCLRBK MA Inhibitor DMCLRBK RN 4-Aminoquinoline melanin-concentrating hormone 1-receptor (MCH1R) antagonists. Bioorg Med Chem Lett. 2006 Oct 15;16(20):5275-9. DMCLRBK RU https://pubmed.ncbi.nlm.nih.gov/16919453 DMV6154 DI DMV6154 DMV6154 DN N-(4-amino-3'-methoxybiphenyl-3-yl)benzamide DMV6154 MI TTSHTOI DMV6154 MN Histone deacetylase 2 (HDAC2) DMV6154 MT DTT DMV6154 MA Inhibitor DMV6154 RN Exploration of the HDAC2 foot pocket: Synthesis and SAR of substituted N-(2-aminophenyl)benzamides. Bioorg Med Chem Lett. 2010 May 15;20(10):3142-5. DMV6154 RU https://pubmed.ncbi.nlm.nih.gov/20392638 DM910BF DI DM910BF DM910BF DN N-(4-amino-3'-methylbiphenyl-3-yl)benzamide DM910BF MI TTSHTOI DM910BF MN Histone deacetylase 2 (HDAC2) DM910BF MT DTT DM910BF MA Inhibitor DM910BF RN Exploration of the HDAC2 foot pocket: Synthesis and SAR of substituted N-(2-aminophenyl)benzamides. Bioorg Med Chem Lett. 2010 May 15;20(10):3142-5. DM910BF RU https://pubmed.ncbi.nlm.nih.gov/20392638 DMIAGS8 DI DMIAGS8 DMIAGS8 DN N-(4-amino-4'-bromobiphenyl-3-yl)benzamide DMIAGS8 MI TTSHTOI DMIAGS8 MN Histone deacetylase 2 (HDAC2) DMIAGS8 MT DTT DMIAGS8 MA Inhibitor DMIAGS8 RN Exploration of the HDAC2 foot pocket: Synthesis and SAR of substituted N-(2-aminophenyl)benzamides. Bioorg Med Chem Lett. 2010 May 15;20(10):3142-5. DMIAGS8 RU https://pubmed.ncbi.nlm.nih.gov/20392638 DMR5D16 DI DMR5D16 DMR5D16 DN N-(4-amino-4'-fluorobiphenyl-3-yl)benzamide DMR5D16 MI TTSHTOI DMR5D16 MN Histone deacetylase 2 (HDAC2) DMR5D16 MT DTT DMR5D16 MA Inhibitor DMR5D16 RN Exploration of the HDAC2 foot pocket: Synthesis and SAR of substituted N-(2-aminophenyl)benzamides. Bioorg Med Chem Lett. 2010 May 15;20(10):3142-5. DMR5D16 RU https://pubmed.ncbi.nlm.nih.gov/20392638 DM93PDA DI DM93PDA DM93PDA DN N-(4-amino-4'-methoxybiphenyl-3-yl)benzamide DM93PDA MI TTSHTOI DM93PDA MN Histone deacetylase 2 (HDAC2) DM93PDA MT DTT DM93PDA MA Inhibitor DM93PDA RN Exploration of the HDAC2 foot pocket: Synthesis and SAR of substituted N-(2-aminophenyl)benzamides. Bioorg Med Chem Lett. 2010 May 15;20(10):3142-5. DM93PDA RU https://pubmed.ncbi.nlm.nih.gov/20392638 DMSUJDH DI DMSUJDH DMSUJDH DN N-(4-amino-4'-vinylbiphenyl-3-yl)benzamide DMSUJDH MI TTSHTOI DMSUJDH MN Histone deacetylase 2 (HDAC2) DMSUJDH MT DTT DMSUJDH MA Inhibitor DMSUJDH RN Exploration of the HDAC2 foot pocket: Synthesis and SAR of substituted N-(2-aminophenyl)benzamides. Bioorg Med Chem Lett. 2010 May 15;20(10):3142-5. DMSUJDH RU https://pubmed.ncbi.nlm.nih.gov/20392638 DMY1FMG DI DMY1FMG DMY1FMG DN N-(4-amino-5-cyano-6-ethoxypyridin-2-yl)acetamide DMY1FMG MI TT3IVG2 DMY1FMG MN JNK2 messenger RNA (JNK2 mRNA) DMY1FMG MT DTT DMY1FMG MA Inhibitor DMY1FMG RN Aminopyridine-based c-Jun N-terminal kinase inhibitors with cellular activity and minimal cross-kinase activity. J Med Chem. 2006 Jun 15;49(12):3563-80. DMY1FMG RU https://pubmed.ncbi.nlm.nih.gov/16759099 DMY1FMG DI DMY1FMG DMY1FMG DN N-(4-amino-5-cyano-6-ethoxypyridin-2-yl)acetamide DMY1FMG MI TT0K6EO DMY1FMG MN Stress-activated protein kinase JNK1 (JNK1) DMY1FMG MT DTT DMY1FMG MA Inhibitor DMY1FMG RN Discovery of potent, highly selective, and orally bioavailable pyridine carboxamide c-Jun NH2-terminal kinase inhibitors. J Med Chem. 2006 Jul 27;49(15):4455-8. DMY1FMG RU https://pubmed.ncbi.nlm.nih.gov/16854050 DMY1FMG DI DMY1FMG DMY1FMG DN N-(4-amino-5-cyano-6-ethoxypyridin-2-yl)acetamide DMY1FMG MI TT056SO DMY1FMG MN Stress-activated protein kinase JNK3 (JNK3) DMY1FMG MT DTT DMY1FMG MA Inhibitor DMY1FMG RN Aminopyridine-based c-Jun N-terminal kinase inhibitors with cellular activity and minimal cross-kinase activity. J Med Chem. 2006 Jun 15;49(12):3563-80. DMY1FMG RU https://pubmed.ncbi.nlm.nih.gov/16759099 DMUFVM6 DI DMUFVM6 DMUFVM6 DN N-(4-amino-5-cyano-6-phenylpyridin-2-yl)acetamide DMUFVM6 MI TT7HF4W DMUFVM6 MN Cyclin-dependent kinase 2 (CDK2) DMUFVM6 MT DTT DMUFVM6 MA Inhibitor DMUFVM6 RN Aminopyridine-based c-Jun N-terminal kinase inhibitors with cellular activity and minimal cross-kinase activity. J Med Chem. 2006 Jun 15;49(12):3563-80. DMUFVM6 RU https://pubmed.ncbi.nlm.nih.gov/16759099 DMUFVM6 DI DMUFVM6 DMUFVM6 DN N-(4-amino-5-cyano-6-phenylpyridin-2-yl)acetamide DMUFVM6 MI TT1F8OQ DMUFVM6 MN IKKA messenger RNA (IKKA mRNA) DMUFVM6 MT DTT DMUFVM6 MA Inhibitor DMUFVM6 RN Aminopyridine-based c-Jun N-terminal kinase inhibitors with cellular activity and minimal cross-kinase activity. J Med Chem. 2006 Jun 15;49(12):3563-80. DMUFVM6 RU https://pubmed.ncbi.nlm.nih.gov/16759099 DMUFVM6 DI DMUFVM6 DMUFVM6 DN N-(4-amino-5-cyano-6-phenylpyridin-2-yl)acetamide DMUFVM6 MI TT3IVG2 DMUFVM6 MN JNK2 messenger RNA (JNK2 mRNA) DMUFVM6 MT DTT DMUFVM6 MA Inhibitor DMUFVM6 RN Aminopyridine-based c-Jun N-terminal kinase inhibitors with cellular activity and minimal cross-kinase activity. J Med Chem. 2006 Jun 15;49(12):3563-80. DMUFVM6 RU https://pubmed.ncbi.nlm.nih.gov/16759099 DMUFVM6 DI DMUFVM6 DMUFVM6 DN N-(4-amino-5-cyano-6-phenylpyridin-2-yl)acetamide DMUFVM6 MI TT0K6EO DMUFVM6 MN Stress-activated protein kinase JNK1 (JNK1) DMUFVM6 MT DTT DMUFVM6 MA Inhibitor DMUFVM6 RN Aminopyridine-based c-Jun N-terminal kinase inhibitors with cellular activity and minimal cross-kinase activity. J Med Chem. 2006 Jun 15;49(12):3563-80. DMUFVM6 RU https://pubmed.ncbi.nlm.nih.gov/16759099 DMUFVM6 DI DMUFVM6 DMUFVM6 DN N-(4-amino-5-cyano-6-phenylpyridin-2-yl)acetamide DMUFVM6 MI TT056SO DMUFVM6 MN Stress-activated protein kinase JNK3 (JNK3) DMUFVM6 MT DTT DMUFVM6 MA Inhibitor DMUFVM6 RN Aminopyridine-based c-Jun N-terminal kinase inhibitors with cellular activity and minimal cross-kinase activity. J Med Chem. 2006 Jun 15;49(12):3563-80. DMUFVM6 RU https://pubmed.ncbi.nlm.nih.gov/16759099 DMSAD87 DI DMSAD87 DMSAD87 DN N-(4-amino-6-butoxy-5-cyanopyridin-2-yl)acetamide DMSAD87 MI TT3IVG2 DMSAD87 MN JNK2 messenger RNA (JNK2 mRNA) DMSAD87 MT DTT DMSAD87 MA Inhibitor DMSAD87 RN Aminopyridine-based c-Jun N-terminal kinase inhibitors with cellular activity and minimal cross-kinase activity. J Med Chem. 2006 Jun 15;49(12):3563-80. DMSAD87 RU https://pubmed.ncbi.nlm.nih.gov/16759099 DMSAD87 DI DMSAD87 DMSAD87 DN N-(4-amino-6-butoxy-5-cyanopyridin-2-yl)acetamide DMSAD87 MI TT0K6EO DMSAD87 MN Stress-activated protein kinase JNK1 (JNK1) DMSAD87 MT DTT DMSAD87 MA Inhibitor DMSAD87 RN Aminopyridine-based c-Jun N-terminal kinase inhibitors with cellular activity and minimal cross-kinase activity. J Med Chem. 2006 Jun 15;49(12):3563-80. DMSAD87 RU https://pubmed.ncbi.nlm.nih.gov/16759099 DMLA92O DI DMLA92O DMLA92O DN N-(4-aminobiphenyl-3-yl)benzamide DMLA92O MI TTSHTOI DMLA92O MN Histone deacetylase 2 (HDAC2) DMLA92O MT DTT DMLA92O MA Inhibitor DMLA92O RN Exploration of the HDAC2 foot pocket: Synthesis and SAR of substituted N-(2-aminophenyl)benzamides. Bioorg Med Chem Lett. 2010 May 15;20(10):3142-5. DMLA92O RU https://pubmed.ncbi.nlm.nih.gov/20392638 DMXVZIY DI DMXVZIY DMXVZIY DN N-(4-aminobiphenyl-3-yl)nicotinamide DMXVZIY MI TTBH0VX DMXVZIY MN Histone deacetylase (HDAC) DMXVZIY MT DTT DMXVZIY MA Inhibitor DMXVZIY RN Bioorg Med Chem Lett. 2008 Dec 1;18(23):6104-9. Epub 2008 Oct 14.SAR profiles of spirocyclic nicotinamide derived selective HDAC1/HDAC2 inhibitors (SHI-1:2). DMXVZIY RU https://pubmed.ncbi.nlm.nih.gov/18951790 DMXVZIY DI DMXVZIY DMXVZIY DN N-(4-aminobiphenyl-3-yl)nicotinamide DMXVZIY MI TT6R7JZ DMXVZIY MN Histone deacetylase 1 (HDAC1) DMXVZIY MT DTT DMXVZIY MA Inhibitor DMXVZIY RN Bioorg Med Chem Lett. 2008 Dec 1;18(23):6104-9. Epub 2008 Oct 14.SAR profiles of spirocyclic nicotinamide derived selective HDAC1/HDAC2 inhibitors (SHI-1:2). DMXVZIY RU https://pubmed.ncbi.nlm.nih.gov/18951790 DMXVZIY DI DMXVZIY DMXVZIY DN N-(4-aminobiphenyl-3-yl)nicotinamide DMXVZIY MI TTSHTOI DMXVZIY MN Histone deacetylase 2 (HDAC2) DMXVZIY MT DTT DMXVZIY MA Inhibitor DMXVZIY RN Bioorg Med Chem Lett. 2008 Dec 1;18(23):6104-9. Epub 2008 Oct 14.SAR profiles of spirocyclic nicotinamide derived selective HDAC1/HDAC2 inhibitors (SHI-1:2). DMXVZIY RU https://pubmed.ncbi.nlm.nih.gov/18951790 DMSNZV1 DI DMSNZV1 DMSNZV1 DN N-(4-bromo-2-methylphenyl)-2-naphthamide DMSNZV1 MI TT3PQ2Y DMSNZV1 MN Plasmodium Dihydroorotate dehydrogenase (Malaria DHOdehase) DMSNZV1 MT DTT DMSNZV1 MA Inhibitor DMSNZV1 RN Design and synthesis of potent inhibitors of the malaria parasite dihydroorotate dehydrogenase. J Med Chem. 2007 Jan 25;50(2):186-91. DMSNZV1 RU https://pubmed.ncbi.nlm.nih.gov/17228860 DMWHYOJ DI DMWHYOJ DMWHYOJ DN N-(4'-bromo-3,3'-difluoro-4-biphenylyl)urea DMWHYOJ MI TTBGTCW DMWHYOJ MN Kinesin spindle messenger RNA (KIF11 mRNA) DMWHYOJ MT DTT DMWHYOJ MA Inhibitor DMWHYOJ RN Novel ATP-competitive kinesin spindle protein inhibitors. J Med Chem. 2007 Oct 4;50(20):4939-52. DMWHYOJ RU https://pubmed.ncbi.nlm.nih.gov/17725339 DMC28SN DI DMC28SN DMC28SN DN N-(4-Bromo-3-methanesulfonyl-benzoyl)-guanidine DMC28SN MI TTGSEFH DMC28SN MN Sodium/hydrogen exchanger 1 (SLC9A1) DMC28SN MT DTT DMC28SN MA Inhibitor DMC28SN RN (2-Methyl-5-(methylsulfonyl)benzoyl)guanidine Na+/H+ antiporter inhibitors. J Med Chem. 1997 Jun 20;40(13):2017-34. DMC28SN RU https://pubmed.ncbi.nlm.nih.gov/9207943 DMC28SN DI DMC28SN DMC28SN DN N-(4-Bromo-3-methanesulfonyl-benzoyl)-guanidine DMC28SN MI TTFZVPO DMC28SN MN Sodium/hydrogen exchanger 3 (SLC9A3) DMC28SN MT DTT DMC28SN MA Inhibitor DMC28SN RN (2-Methyl-5-(methylsulfonyl)benzoyl)guanidine Na+/H+ antiporter inhibitors. J Med Chem. 1997 Jun 20;40(13):2017-34. DMC28SN RU https://pubmed.ncbi.nlm.nih.gov/9207943 DMFG6MU DI DMFG6MU DMFG6MU DN N-(4-Chloro-3-methanesulfonyl-benzoyl)-guanidine DMFG6MU MI TTGSEFH DMFG6MU MN Sodium/hydrogen exchanger 1 (SLC9A1) DMFG6MU MT DTT DMFG6MU MA Inhibitor DMFG6MU RN (2-Methyl-5-(methylsulfonyl)benzoyl)guanidine Na+/H+ antiporter inhibitors. J Med Chem. 1997 Jun 20;40(13):2017-34. DMFG6MU RU https://pubmed.ncbi.nlm.nih.gov/9207943 DMFG6MU DI DMFG6MU DMFG6MU DN N-(4-Chloro-3-methanesulfonyl-benzoyl)-guanidine DMFG6MU MI TTFZVPO DMFG6MU MN Sodium/hydrogen exchanger 3 (SLC9A3) DMFG6MU MT DTT DMFG6MU MA Inhibitor DMFG6MU RN (2-Methyl-5-(methylsulfonyl)benzoyl)guanidine Na+/H+ antiporter inhibitors. J Med Chem. 1997 Jun 20;40(13):2017-34. DMFG6MU RU https://pubmed.ncbi.nlm.nih.gov/9207943 DM0ARP8 DI DM0ARP8 DM0ARP8 DN N-(4'-chloro-4-biphenylyl)methanesulfonamide DM0ARP8 MI TTBGTCW DM0ARP8 MN Kinesin spindle messenger RNA (KIF11 mRNA) DM0ARP8 MT DTT DM0ARP8 MA Inhibitor DM0ARP8 RN Novel ATP-competitive kinesin spindle protein inhibitors. J Med Chem. 2007 Oct 4;50(20):4939-52. DM0ARP8 RU https://pubmed.ncbi.nlm.nih.gov/17725339 DMNO46U DI DMNO46U DMNO46U DN N-(4-Chloro-7-p-tolyl-isoquinolin-1-yl)-guanidine DMNO46U MI TTP86E2 DMNO46U MN Plasminogen (PLG) DMNO46U MT DTT DMNO46U MA Inhibitor DMNO46U RN Selective urokinase-type plasminogen activator (uPA) inhibitors. Part 3: 1-isoquinolinylguanidines. Bioorg Med Chem Lett. 2004 Jun 21;14(12):3227-30. DMNO46U RU https://pubmed.ncbi.nlm.nih.gov/15149680 DMNO46U DI DMNO46U DMNO46U DN N-(4-Chloro-7-p-tolyl-isoquinolin-1-yl)-guanidine DMNO46U MI TTXAGYU DMNO46U MN Tissue-type plasminogen activator (PLAT) DMNO46U MT DTT DMNO46U MA Inhibitor DMNO46U RN Selective urokinase-type plasminogen activator (uPA) inhibitors. Part 3: 1-isoquinolinylguanidines. Bioorg Med Chem Lett. 2004 Jun 21;14(12):3227-30. DMNO46U RU https://pubmed.ncbi.nlm.nih.gov/15149680 DMGI9EA DI DMGI9EA DMGI9EA DN N-(4-Cyano-3-methanesulfonyl-benzoyl)-guanidine DMGI9EA MI TTGSEFH DMGI9EA MN Sodium/hydrogen exchanger 1 (SLC9A1) DMGI9EA MT DTT DMGI9EA MA Inhibitor DMGI9EA RN (2-Methyl-5-(methylsulfonyl)benzoyl)guanidine Na+/H+ antiporter inhibitors. J Med Chem. 1997 Jun 20;40(13):2017-34. DMGI9EA RU https://pubmed.ncbi.nlm.nih.gov/9207943 DMGI9EA DI DMGI9EA DMGI9EA DN N-(4-Cyano-3-methanesulfonyl-benzoyl)-guanidine DMGI9EA MI TTFZVPO DMGI9EA MN Sodium/hydrogen exchanger 3 (SLC9A3) DMGI9EA MT DTT DMGI9EA MA Inhibitor DMGI9EA RN (2-Methyl-5-(methylsulfonyl)benzoyl)guanidine Na+/H+ antiporter inhibitors. J Med Chem. 1997 Jun 20;40(13):2017-34. DMGI9EA RU https://pubmed.ncbi.nlm.nih.gov/9207943 DMW8S2D DI DMW8S2D DMW8S2D DN N-(4-cyanophenyl)sulfamide DMW8S2D MI TTHQPL7 DMW8S2D MN Carbonic anhydrase I (CA-I) DMW8S2D MT DTT DMW8S2D MA Inhibitor DMW8S2D RN Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, IX, and XII with N-hydroxy... Bioorg Med Chem Lett. 2005 May 2;15(9):2353-8. DMW8S2D RU https://pubmed.ncbi.nlm.nih.gov/15837324 DMW8S2D DI DMW8S2D DMW8S2D DN N-(4-cyanophenyl)sulfamide DMW8S2D MI TTANPDJ DMW8S2D MN Carbonic anhydrase II (CA-II) DMW8S2D MT DTT DMW8S2D MA Inhibitor DMW8S2D RN Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, IX, and XII with N-hydroxy... Bioorg Med Chem Lett. 2005 May 2;15(9):2353-8. DMW8S2D RU https://pubmed.ncbi.nlm.nih.gov/15837324 DMW8S2D DI DMW8S2D DMW8S2D DN N-(4-cyanophenyl)sulfamide DMW8S2D MI TT2LVK8 DMW8S2D MN Carbonic anhydrase IX (CA-IX) DMW8S2D MT DTT DMW8S2D MA Inhibitor DMW8S2D RN Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, IX, and XII with N-hydroxy... Bioorg Med Chem Lett. 2005 May 2;15(9):2353-8. DMW8S2D RU https://pubmed.ncbi.nlm.nih.gov/15837324 DMW8S2D DI DMW8S2D DMW8S2D DN N-(4-cyanophenyl)sulfamide DMW8S2D MI TTSYM0R DMW8S2D MN Carbonic anhydrase XII (CA-XII) DMW8S2D MT DTT DMW8S2D MA Inhibitor DMW8S2D RN Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, IX, and XII with N-hydroxy... Bioorg Med Chem Lett. 2005 May 2;15(9):2353-8. DMW8S2D RU https://pubmed.ncbi.nlm.nih.gov/15837324 DMB3E7H DI DMB3E7H DMB3E7H DN N-(4-Dimethylamino-but-2-ynyl)-N-methyl-acetamide DMB3E7H MI TTZ9SOR DMB3E7H MN Muscarinic acetylcholine receptor M1 (CHRM1) DMB3E7H MT DTT DMB3E7H MA Inhibitor DMB3E7H RN Cholinergic agents: aldehyde, ketone, and oxime analogues of the muscarinic agonist UH5, Bioorg. Med. Chem. Lett. 2(8):803-808 (1992). DMB3E7H RU http://www.sciencedirect.com/science/article/pii/S0960894X00805351 DMB3E7H DI DMB3E7H DMB3E7H DN N-(4-Dimethylamino-but-2-ynyl)-N-methyl-acetamide DMB3E7H MI TTYEG6Q DMB3E7H MN Muscarinic acetylcholine receptor M2 (CHRM2) DMB3E7H MT DTT DMB3E7H MA Inhibitor DMB3E7H RN Cholinergic agents: aldehyde, ketone, and oxime analogues of the muscarinic agonist UH5, Bioorg. Med. Chem. Lett. 2(8):803-808 (1992). DMB3E7H RU http://www.sciencedirect.com/science/article/pii/S0960894X00805351 DMB3E7H DI DMB3E7H DMB3E7H DN N-(4-Dimethylamino-but-2-ynyl)-N-methyl-acetamide DMB3E7H MI TTQ13Z5 DMB3E7H MN Muscarinic acetylcholine receptor M3 (CHRM3) DMB3E7H MT DTT DMB3E7H MA Inhibitor DMB3E7H RN Cholinergic agents: aldehyde, ketone, and oxime analogues of the muscarinic agonist UH5, Bioorg. Med. Chem. Lett. 2(8):803-808 (1992). DMB3E7H RU http://www.sciencedirect.com/science/article/pii/S0960894X00805351 DMB3E7H DI DMB3E7H DMB3E7H DN N-(4-Dimethylamino-but-2-ynyl)-N-methyl-acetamide DMB3E7H MI TTQ3JTF DMB3E7H MN Muscarinic acetylcholine receptor M4 (CHRM4) DMB3E7H MT DTT DMB3E7H MA Inhibitor DMB3E7H RN Cholinergic agents: aldehyde, ketone, and oxime analogues of the muscarinic agonist UH5, Bioorg. Med. Chem. Lett. 2(8):803-808 (1992). DMB3E7H RU http://www.sciencedirect.com/science/article/pii/S0960894X00805351 DMB3E7H DI DMB3E7H DMB3E7H DN N-(4-Dimethylamino-but-2-ynyl)-N-methyl-acetamide DMB3E7H MI TTH18TF DMB3E7H MN Muscarinic acetylcholine receptor M5 (CHRM5) DMB3E7H MT DTT DMB3E7H MA Inhibitor DMB3E7H RN Cholinergic agents: aldehyde, ketone, and oxime analogues of the muscarinic agonist UH5, Bioorg. Med. Chem. Lett. 2(8):803-808 (1992). DMB3E7H RU http://www.sciencedirect.com/science/article/pii/S0960894X00805351 DMU1ATH DI DMU1ATH DMU1ATH DN N-(4-Dipropylaminobutyl)-4-biphenylcarboxamide DMU1ATH MI TTZFYLI DMU1ATH MN Dopamine D1 receptor (D1R) DMU1ATH MT DTT DMU1ATH MA Inhibitor DMU1ATH RN Novel D3 selective dopaminergics incorporating enyne units as nonaromatic catechol bioisosteres: synthesis, bioactivity, and mutagenesis studies. J Med Chem. 2008 Nov 13;51(21):6829-38. DMU1ATH RU https://pubmed.ncbi.nlm.nih.gov/18834111 DMU1ATH DI DMU1ATH DMU1ATH DN N-(4-Dipropylaminobutyl)-4-biphenylcarboxamide DMU1ATH MI TTEX248 DMU1ATH MN Dopamine D2 receptor (D2R) DMU1ATH MT DTT DMU1ATH MA Inhibitor DMU1ATH RN Novel D3 selective dopaminergics incorporating enyne units as nonaromatic catechol bioisosteres: synthesis, bioactivity, and mutagenesis studies. J Med Chem. 2008 Nov 13;51(21):6829-38. DMU1ATH RU https://pubmed.ncbi.nlm.nih.gov/18834111 DMU1ATH DI DMU1ATH DMU1ATH DN N-(4-Dipropylaminobutyl)-4-biphenylcarboxamide DMU1ATH MI TT4C8EA DMU1ATH MN Dopamine D3 receptor (D3R) DMU1ATH MT DTT DMU1ATH MA Inhibitor DMU1ATH RN Novel D3 selective dopaminergics incorporating enyne units as nonaromatic catechol bioisosteres: synthesis, bioactivity, and mutagenesis studies. J Med Chem. 2008 Nov 13;51(21):6829-38. DMU1ATH RU https://pubmed.ncbi.nlm.nih.gov/18834111 DMU1ATH DI DMU1ATH DMU1ATH DN N-(4-Dipropylaminobutyl)-4-biphenylcarboxamide DMU1ATH MI TTE0A2F DMU1ATH MN Dopamine D4 receptor (D4R) DMU1ATH MT DTT DMU1ATH MA Inhibitor DMU1ATH RN Novel D3 selective dopaminergics incorporating enyne units as nonaromatic catechol bioisosteres: synthesis, bioactivity, and mutagenesis studies. J Med Chem. 2008 Nov 13;51(21):6829-38. DMU1ATH RU https://pubmed.ncbi.nlm.nih.gov/18834111 DM012TN DI DM012TN DM012TN DN N-(4-Ethoxybutyl)-2-oxohexadecanamide DM012TN MI TTT1JVS DM012TN MN Cytosolic phospholipase A2 (GIVA cPLA2) DM012TN MT DTT DM012TN MA Inhibitor DM012TN RN Structure-activity relationships of natural and non-natural amino acid-based amide and 2-oxoamide inhibitors of human phospholipase A(2) enzymes. Bioorg Med Chem. 2008 Dec 15;16(24):10257-69. DM012TN RU https://pubmed.ncbi.nlm.nih.gov/18993078 DMWTVJH DI DMWTVJH DMWTVJH DN N-(4-Ethylphenyl)-2-oxo-2H-chromene-3-carboxamide DMWTVJH MI TT3WG5C DMWTVJH MN Monoamine oxidase type A (MAO-A) DMWTVJH MT DTT DMWTVJH MA Inhibitor DMWTVJH RN Synthesis, molecular modeling, and selective inhibitory activity against human monoamine oxidases of 3-carboxamido-7-substituted coumarins. J Med Chem. 2009 Apr 9;52(7):1935-42. DMWTVJH RU https://pubmed.ncbi.nlm.nih.gov/19267475 DMWTVJH DI DMWTVJH DMWTVJH DN N-(4-Ethylphenyl)-2-oxo-2H-chromene-3-carboxamide DMWTVJH MI TTGP7BY DMWTVJH MN Monoamine oxidase type B (MAO-B) DMWTVJH MT DTT DMWTVJH MA Inhibitor DMWTVJH RN Synthesis, molecular modeling, and selective inhibitory activity against human monoamine oxidases of 3-carboxamido-7-substituted coumarins. J Med Chem. 2009 Apr 9;52(7):1935-42. DMWTVJH RU https://pubmed.ncbi.nlm.nih.gov/19267475 DMIWNAY DI DMIWNAY DMIWNAY DN N-(4-Ethylphenyl)-5-methylbenzo[d]oxazol-2-amine DMIWNAY MI TT2J34L DMIWNAY MN Arachidonate 5-lipoxygenase (5-LOX) DMIWNAY MT DTT DMIWNAY MA Inhibitor DMIWNAY RN Synthesis and evaluation of benzoxazole derivatives as 5-lipoxygenase inhibitors. Bioorg Med Chem. 2010 Nov 1;18(21):7580-5. DMIWNAY RU https://pubmed.ncbi.nlm.nih.gov/20870413 DMJ73T6 DI DMJ73T6 DMJ73T6 DN N-(4-Ethylphenyl)benzo[d]oxazol-2-amine DMJ73T6 MI TT2J34L DMJ73T6 MN Arachidonate 5-lipoxygenase (5-LOX) DMJ73T6 MT DTT DMJ73T6 MA Inhibitor DMJ73T6 RN Synthesis and evaluation of benzoxazole derivatives as 5-lipoxygenase inhibitors. Bioorg Med Chem. 2010 Nov 1;18(21):7580-5. DMJ73T6 RU https://pubmed.ncbi.nlm.nih.gov/20870413 DMKN8U6 DI DMKN8U6 DMKN8U6 DN N-(4-Ethylphenyl)-N'-hydroxyoctanediamide DMKN8U6 MI TTBH0VX DMKN8U6 MN Histone deacetylase (HDAC) DMKN8U6 MT DTT DMKN8U6 MA Inhibitor DMKN8U6 RN Biological and biophysical properties of the histone deacetylase inhibitor suberoylanilide hydroxamic acid are affected by the presence of short al... J Med Chem. 2010 Mar 11;53(5):1937-50. DMKN8U6 RU https://pubmed.ncbi.nlm.nih.gov/20143840 DMKN8U6 DI DMKN8U6 DMKN8U6 DN N-(4-Ethylphenyl)-N'-hydroxyoctanediamide DMKN8U6 MI TT6R7JZ DMKN8U6 MN Histone deacetylase 1 (HDAC1) DMKN8U6 MT DTT DMKN8U6 MA Inhibitor DMKN8U6 RN Biological and biophysical properties of the histone deacetylase inhibitor suberoylanilide hydroxamic acid are affected by the presence of short al... J Med Chem. 2010 Mar 11;53(5):1937-50. DMKN8U6 RU https://pubmed.ncbi.nlm.nih.gov/20143840 DMP1ICB DI DMP1ICB DMP1ICB DN N-(4-fluorobenzyl)-N-(pyridin-4-yl)-2-naphthamide DMP1ICB MI TTQBR95 DMP1ICB MN Stress-activated protein kinase 2a (p38 alpha) DMP1ICB MT DTT DMP1ICB MA Inhibitor DMP1ICB RN Amide-based inhibitors of p38alpha MAP kinase. Part 2: design, synthesis and SAR of potent N-pyrimidyl amides. Bioorg Med Chem Lett. 2010 Apr 15;20(8):2560-3. DMP1ICB RU https://pubmed.ncbi.nlm.nih.gov/20346659 DM7O5WS DI DM7O5WS DM7O5WS DN N-(4-hydroxybenzyl)icosa-5,8,11,14-tetraenamide DM7O5WS MI TT6OEDT DM7O5WS MN Cannabinoid receptor 1 (CB1) DM7O5WS MT DTT DM7O5WS MA Inhibitor DM7O5WS RN New analgesics synthetically derived from the paracetamol metabolite N-(4-hydroxyphenyl)-(5Z,8Z,11Z,14Z)-icosatetra-5,8,11,14-enamide. J Med Chem. 2008 Dec 25;51(24):7800-5. DM7O5WS RU https://pubmed.ncbi.nlm.nih.gov/19053765 DM7O5WS DI DM7O5WS DM7O5WS DN N-(4-hydroxybenzyl)icosa-5,8,11,14-tetraenamide DM7O5WS MI TTMSFAW DM7O5WS MN Cannabinoid receptor 2 (CB2) DM7O5WS MT DTT DM7O5WS MA Inhibitor DM7O5WS RN New analgesics synthetically derived from the paracetamol metabolite N-(4-hydroxyphenyl)-(5Z,8Z,11Z,14Z)-icosatetra-5,8,11,14-enamide. J Med Chem. 2008 Dec 25;51(24):7800-5. DM7O5WS RU https://pubmed.ncbi.nlm.nih.gov/19053765 DM7O5WS DI DM7O5WS DM7O5WS DN N-(4-hydroxybenzyl)icosa-5,8,11,14-tetraenamide DM7O5WS MI TTDP1UC DM7O5WS MN Fatty acid amide hydrolase (FAAH) DM7O5WS MT DTT DM7O5WS MA Inhibitor DM7O5WS RN New analgesics synthetically derived from the paracetamol metabolite N-(4-hydroxyphenyl)-(5Z,8Z,11Z,14Z)-icosatetra-5,8,11,14-enamide. J Med Chem. 2008 Dec 25;51(24):7800-5. DM7O5WS RU https://pubmed.ncbi.nlm.nih.gov/19053765 DMC5H8G DI DMC5H8G DMC5H8G DN N-(4-hydroxybiphenyl-3-yl)benzamide DMC5H8G MI TT6R7JZ DMC5H8G MN Histone deacetylase 1 (HDAC1) DMC5H8G MT DTT DMC5H8G MA Inhibitor DMC5H8G RN Bioorg Med Chem Lett. 2008 Dec 1;18(23):6104-9. Epub 2008 Oct 14.SAR profiles of spirocyclic nicotinamide derived selective HDAC1/HDAC2 inhibitors (SHI-1:2). DMC5H8G RU https://pubmed.ncbi.nlm.nih.gov/18951790 DMC5H8G DI DMC5H8G DMC5H8G DN N-(4-hydroxybiphenyl-3-yl)benzamide DMC5H8G MI TTSHTOI DMC5H8G MN Histone deacetylase 2 (HDAC2) DMC5H8G MT DTT DMC5H8G MA Inhibitor DMC5H8G RN Bioorg Med Chem Lett. 2008 Dec 1;18(23):6104-9. Epub 2008 Oct 14.SAR profiles of spirocyclic nicotinamide derived selective HDAC1/HDAC2 inhibitors (SHI-1:2). DMC5H8G RU https://pubmed.ncbi.nlm.nih.gov/18951790 DM4QR2C DI DM4QR2C DM4QR2C DN N-(4-hydroxyphenylpropanyl)-spermine DM4QR2C MI TTAN6JD DM4QR2C MN Glutamate receptor AMPA (GRIA) DM4QR2C MT DTT DM4QR2C MA Inhibitor DM4QR2C RN Developing a complete pharmacology for AMPA receptors: a perspective on subtype-selective ligands. Bioorg Med Chem. 2010 Feb 15;18(4):1381-7. DM4QR2C RU https://pubmed.ncbi.nlm.nih.gov/20096591 DM4QR2C DI DM4QR2C DM4QR2C DN N-(4-hydroxyphenylpropanyl)-spermine DM4QR2C MI TTVPQTF DM4QR2C MN Glutamate receptor AMPA 1 (GRIA1) DM4QR2C MT DTT DM4QR2C MA Inhibitor DM4QR2C RN Developing a complete pharmacology for AMPA receptors: a perspective on subtype-selective ligands. Bioorg Med Chem. 2010 Feb 15;18(4):1381-7. DM4QR2C RU https://pubmed.ncbi.nlm.nih.gov/20096591 DM6GFRP DI DM6GFRP DM6GFRP DN N-(4-iodophenyl)-4-(trifluoromethoxy)benzamide DM6GFRP MI TTMI6F5 DM6GFRP MN Transient receptor potential cation channel V1 (TRPV1) DM6GFRP MT DTT DM6GFRP MA Inhibitor DM6GFRP RN Synthesis of benzamide derivatives as TRPV1 antagonists. Bioorg Med Chem Lett. 2008 Feb 1;18(3):1072-8. DM6GFRP RU https://pubmed.ncbi.nlm.nih.gov/18155908 DMK9FQG DI DMK9FQG DMK9FQG DN N-(4-iodophenyl)-4-(trifluoromethyl)benzamide DMK9FQG MI TTMI6F5 DMK9FQG MN Transient receptor potential cation channel V1 (TRPV1) DMK9FQG MT DTT DMK9FQG MA Inhibitor DMK9FQG RN Synthesis of benzamide derivatives as TRPV1 antagonists. Bioorg Med Chem Lett. 2008 Feb 1;18(3):1072-8. DMK9FQG RU https://pubmed.ncbi.nlm.nih.gov/18155908 DMHANU5 DI DMHANU5 DMHANU5 DN N-(4-Iodophenyl)-N'-(17-methylmorphinan-3-yl)urea DMHANU5 MI TT27RFC DMHANU5 MN Opioid receptor delta (OPRD1) DMHANU5 MT DTT DMHANU5 MA Inhibitor DMHANU5 RN Synthesis and opioid receptor binding affinities of 2-substituted and 3-aminomorphinans: ligands for mu, kappa, and delta opioid receptors. J Med Chem. 2010 Jan 14;53(1):402-18. DMHANU5 RU https://pubmed.ncbi.nlm.nih.gov/19928862 DMHANU5 DI DMHANU5 DMHANU5 DN N-(4-Iodophenyl)-N'-(17-methylmorphinan-3-yl)urea DMHANU5 MI TTQW87Y DMHANU5 MN Opioid receptor kappa (OPRK1) DMHANU5 MT DTT DMHANU5 MA Inhibitor DMHANU5 RN Synthesis and opioid receptor binding affinities of 2-substituted and 3-aminomorphinans: ligands for mu, kappa, and delta opioid receptors. J Med Chem. 2010 Jan 14;53(1):402-18. DMHANU5 RU https://pubmed.ncbi.nlm.nih.gov/19928862 DMHANU5 DI DMHANU5 DMHANU5 DN N-(4-Iodophenyl)-N'-(17-methylmorphinan-3-yl)urea DMHANU5 MI TTKWM86 DMHANU5 MN Opioid receptor mu (MOP) DMHANU5 MT DTT DMHANU5 MA Inhibitor DMHANU5 RN Synthesis and opioid receptor binding affinities of 2-substituted and 3-aminomorphinans: ligands for mu, kappa, and delta opioid receptors. J Med Chem. 2010 Jan 14;53(1):402-18. DMHANU5 RU https://pubmed.ncbi.nlm.nih.gov/19928862 DM2N3TG DI DM2N3TG DM2N3TG DN N-(4'-Isonicotinoylbiphenyl-3-yl)acetamide DM2N3TG MI TTIQUX7 DM2N3TG MN Steroid 11-beta-hydroxylase (CYP11B1) DM2N3TG MT DTT DM2N3TG MA Inhibitor DM2N3TG RN Replacement of imidazolyl by pyridyl in biphenylmethylenes results in selective CYP17 and dual CYP17/CYP11B1 inhibitors for the treatment of prosta... J Med Chem. 2010 Aug 12;53(15):5749-58. DM2N3TG RU https://pubmed.ncbi.nlm.nih.gov/20684610 DM2N3TG DI DM2N3TG DM2N3TG DN N-(4'-Isonicotinoylbiphenyl-3-yl)acetamide DM2N3TG MI TTRA5BZ DM2N3TG MN Steroid 17-alpha-monooxygenase (S17AH) DM2N3TG MT DTT DM2N3TG MA Inhibitor DM2N3TG RN Replacement of imidazolyl by pyridyl in biphenylmethylenes results in selective CYP17 and dual CYP17/CYP11B1 inhibitors for the treatment of prosta... J Med Chem. 2010 Aug 12;53(15):5749-58. DM2N3TG RU https://pubmed.ncbi.nlm.nih.gov/20684610 DM2MGSO DI DM2MGSO DM2MGSO DN N-(4'-isopropyl-4-biphenylyl)urea DM2MGSO MI TTBGTCW DM2MGSO MN Kinesin spindle messenger RNA (KIF11 mRNA) DM2MGSO MT DTT DM2MGSO MA Inhibitor DM2MGSO RN Novel ATP-competitive kinesin spindle protein inhibitors. J Med Chem. 2007 Oct 4;50(20):4939-52. DM2MGSO RU https://pubmed.ncbi.nlm.nih.gov/17725339 DMHM3LC DI DMHM3LC DMHM3LC DN N-(4-methoxybenzyl)oleamide DMHM3LC MI TT6OEDT DMHM3LC MN Cannabinoid receptor 1 (CB1) DMHM3LC MT DTT DMHM3LC MA Inhibitor DMHM3LC RN New metabolically stable fatty acid amide ligands of cannabinoid receptors: Synthesis and receptor affinity studies. Bioorg Med Chem Lett. 2006 Jan 1;16(1):138-41. DMHM3LC RU https://pubmed.ncbi.nlm.nih.gov/16213718 DM5NOSM DI DM5NOSM DM5NOSM DN N-(4-methoxyphenethyl)oleamide DM5NOSM MI TT6OEDT DM5NOSM MN Cannabinoid receptor 1 (CB1) DM5NOSM MT DTT DM5NOSM MA Inhibitor DM5NOSM RN New metabolically stable fatty acid amide ligands of cannabinoid receptors: Synthesis and receptor affinity studies. Bioorg Med Chem Lett. 2006 Jan 1;16(1):138-41. DM5NOSM RU https://pubmed.ncbi.nlm.nih.gov/16213718 DMJVPK6 DI DMJVPK6 DMJVPK6 DN N-(4-methoxyphenyl)oleamide DMJVPK6 MI TT6OEDT DMJVPK6 MN Cannabinoid receptor 1 (CB1) DMJVPK6 MT DTT DMJVPK6 MA Inhibitor DMJVPK6 RN New metabolically stable fatty acid amide ligands of cannabinoid receptors: Synthesis and receptor affinity studies. Bioorg Med Chem Lett. 2006 Jan 1;16(1):138-41. DMJVPK6 RU https://pubmed.ncbi.nlm.nih.gov/16213718 DMO8L57 DI DMO8L57 DMO8L57 DN N-(4'-methyl-4-biphenylyl)urea DMO8L57 MI TTBGTCW DMO8L57 MN Kinesin spindle messenger RNA (KIF11 mRNA) DMO8L57 MT DTT DMO8L57 MA Inhibitor DMO8L57 RN Novel ATP-competitive kinesin spindle protein inhibitors. J Med Chem. 2007 Oct 4;50(20):4939-52. DMO8L57 RU https://pubmed.ncbi.nlm.nih.gov/17725339 DMCZD37 DI DMCZD37 DMCZD37 DN N-(4-Methyl-benzoyl)-N'-phenethyl-guanidine DMCZD37 MI TTZOVE0 DMCZD37 MN Voltage-gated sodium channel alpha Nav1.5 (SCN5A) DMCZD37 MT DTT DMCZD37 MA Inhibitor DMCZD37 RN Solution-phase, parallel synthesis and pharmacological evaluation of acylguanidine derivatives as potential sodium channel blockers. Bioorg Med Chem Lett. 2001 Dec 17;11(24):3151-5. DMCZD37 RU https://pubmed.ncbi.nlm.nih.gov/11720863 DMZX2BH DI DMZX2BH DMZX2BH DN N-(4-methyl-benzyl)-4-phenoxy-benzamide DMZX2BH MI TTQBR95 DMZX2BH MN Stress-activated protein kinase 2a (p38 alpha) DMZX2BH MT DTT DMZX2BH MA Inhibitor DMZX2BH RN Two classes of p38alpha MAP kinase inhibitors having a common diphenylether core but exhibiting divergent binding modes. Bioorg Med Chem Lett. 2005 Dec 1;15(23):5274-9. DMZX2BH RU https://pubmed.ncbi.nlm.nih.gov/16169718 DMXNMTD DI DMXNMTD DMXNMTD DN N-(4'-methyl-piperazinyl) estradiol-16-carboxamide DMXNMTD MI TTIWB6L DMXNMTD MN Estradiol 17 beta-dehydrogenase 1 (17-beta-HSD1) DMXNMTD MT DTT DMXNMTD MA Inhibitor DMXNMTD RN Modification of estrone at the 6, 16, and 17 positions: novel potent inhibitors of 17beta-hydroxysteroid dehydrogenase type 1. J Med Chem. 2006 Feb 23;49(4):1325-45. DMXNMTD RU https://pubmed.ncbi.nlm.nih.gov/16480268 DM03VXN DI DM03VXN DM03VXN DN N-(4-methylthiazol-2-yl)-2-phenylacetamide DM03VXN MI TTSJ6Q4 DM03VXN MN LOX-5 messenger RNA (ALOX5 mRNA) DM03VXN MT DTT DM03VXN MA Inhibitor DM03VXN RN Identification of natural-product-derived inhibitors of 5-lipoxygenase activity by ligand-based virtual screening. J Med Chem. 2007 May 31;50(11):2640-6. DM03VXN RU https://pubmed.ncbi.nlm.nih.gov/17461565 DMTCA2Z DI DMTCA2Z DMTCA2Z DN N-(4-methylthiazol-2-yl)benzamide DMTCA2Z MI TTSJ6Q4 DMTCA2Z MN LOX-5 messenger RNA (ALOX5 mRNA) DMTCA2Z MT DTT DMTCA2Z MA Inhibitor DMTCA2Z RN Identification of natural-product-derived inhibitors of 5-lipoxygenase activity by ligand-based virtual screening. J Med Chem. 2007 May 31;50(11):2640-6. DMTCA2Z RU https://pubmed.ncbi.nlm.nih.gov/17461565 DMGRFYV DI DMGRFYV DMGRFYV DN N-(4-morpholinophenyl)docos-13-enamide DMGRFYV MI TT6OEDT DMGRFYV MN Cannabinoid receptor 1 (CB1) DMGRFYV MT DTT DMGRFYV MA Inhibitor DMGRFYV RN New metabolically stable fatty acid amide ligands of cannabinoid receptors: Synthesis and receptor affinity studies. Bioorg Med Chem Lett. 2006 Jan 1;16(1):138-41. DMGRFYV RU https://pubmed.ncbi.nlm.nih.gov/16213718 DMEBGF1 DI DMEBGF1 DMEBGF1 DN N-(4-m-Tolylamino-quinazolin-6-yl)-acrylamide DMEBGF1 MI TTGKNB4 DMEBGF1 MN Epidermal growth factor receptor (EGFR) DMEBGF1 MT DTT DMEBGF1 MA Inhibitor DMEBGF1 RN Tyrosine kinase inhibitors. 15. 4-(Phenylamino)quinazoline and 4-(phenylamino)pyrido[d]pyrimidine acrylamides as irreversible inhibitors of the ATP... J Med Chem. 1999 May 20;42(10):1803-15. DMEBGF1 RU https://pubmed.ncbi.nlm.nih.gov/10346932 DMEBGF1 DI DMEBGF1 DMEBGF1 DN N-(4-m-Tolylamino-quinazolin-6-yl)-acrylamide DMEBGF1 MI TTR5TV4 DMEBGF1 MN ERBB2 messenger RNA (HER2 mRNA) DMEBGF1 MT DTT DMEBGF1 MA Inhibitor DMEBGF1 RN Tyrosine kinase inhibitors. 15. 4-(Phenylamino)quinazoline and 4-(phenylamino)pyrido[d]pyrimidine acrylamides as irreversible inhibitors of the ATP... J Med Chem. 1999 May 20;42(10):1803-15. DMEBGF1 RU https://pubmed.ncbi.nlm.nih.gov/10346932 DMG6RTJ DI DMG6RTJ DMG6RTJ DN N-(4-m-Tolylamino-quinazolin-7-yl)-acrylamide DMG6RTJ MI TTGKNB4 DMG6RTJ MN Epidermal growth factor receptor (EGFR) DMG6RTJ MT DTT DMG6RTJ MA Inhibitor DMG6RTJ RN Tyrosine kinase inhibitors. 15. 4-(Phenylamino)quinazoline and 4-(phenylamino)pyrido[d]pyrimidine acrylamides as irreversible inhibitors of the ATP... J Med Chem. 1999 May 20;42(10):1803-15. DMG6RTJ RU https://pubmed.ncbi.nlm.nih.gov/10346932 DMUJS4Y DI DMUJS4Y DMUJS4Y DN N-(4-phenylbenzoyl)-phenylalanyl-glycine-nitrile DMUJS4Y MI TTDZN01 DMUJS4Y MN Cathepsin K (CTSK) DMUJS4Y MT DTT DMUJS4Y MA Inhibitor DMUJS4Y RN Interaction of papain-like cysteine proteases with dipeptide-derived nitriles. J Med Chem. 2005 Dec 1;48(24):7688-707. DMUJS4Y RU https://pubmed.ncbi.nlm.nih.gov/16302809 DMUJS4Y DI DMUJS4Y DMUJS4Y DN N-(4-phenylbenzoyl)-phenylalanyl-glycine-nitrile DMUJS4Y MI TT36ETB DMUJS4Y MN Cathepsin L (CTSL) DMUJS4Y MT DTT DMUJS4Y MA Inhibitor DMUJS4Y RN Interaction of papain-like cysteine proteases with dipeptide-derived nitriles. J Med Chem. 2005 Dec 1;48(24):7688-707. DMUJS4Y RU https://pubmed.ncbi.nlm.nih.gov/16302809 DMUJS4Y DI DMUJS4Y DMUJS4Y DN N-(4-phenylbenzoyl)-phenylalanyl-glycine-nitrile DMUJS4Y MI TTUMQVO DMUJS4Y MN Cathepsin S (CTSS) DMUJS4Y MT DTT DMUJS4Y MA Inhibitor DMUJS4Y RN Interaction of papain-like cysteine proteases with dipeptide-derived nitriles. J Med Chem. 2005 Dec 1;48(24):7688-707. DMUJS4Y RU https://pubmed.ncbi.nlm.nih.gov/16302809 DMTCMUG DI DMTCMUG DMTCMUG DN N-(4-Phenylbutyl)-1H-indole-2-carboxamide DMTCMUG MI TT3WG5C DMTCMUG MN Monoamine oxidase type A (MAO-A) DMTCMUG MT DTT DMTCMUG MA Inhibitor DMTCMUG RN Synthesis, structure-activity relationships and molecular modeling studies of new indole inhibitors of monoamine oxidases A and B. Bioorg Med Chem. 2008 Nov 15;16(22):9729-40. DMTCMUG RU https://pubmed.ncbi.nlm.nih.gov/18951803 DMTCMUG DI DMTCMUG DMTCMUG DN N-(4-Phenylbutyl)-1H-indole-2-carboxamide DMTCMUG MI TTGP7BY DMTCMUG MN Monoamine oxidase type B (MAO-B) DMTCMUG MT DTT DMTCMUG MA Inhibitor DMTCMUG RN Synthesis, structure-activity relationships and molecular modeling studies of new indole inhibitors of monoamine oxidases A and B. Bioorg Med Chem. 2008 Nov 15;16(22):9729-40. DMTCMUG RU https://pubmed.ncbi.nlm.nih.gov/18951803 DMSREW5 DI DMSREW5 DMSREW5 DN N-(4-phenylbutyl)-1H-pyrrole-2-carboxamide DMSREW5 MI TT3WG5C DMSREW5 MN Monoamine oxidase type A (MAO-A) DMSREW5 MT DTT DMSREW5 MA Inhibitor DMSREW5 RN New pyrrole inhibitors of monoamine oxidase: synthesis, biological evaluation, and structural determinants of MAO-A and MAO-B selectivity. J Med Chem. 2007 Mar 8;50(5):922-31. DMSREW5 RU https://pubmed.ncbi.nlm.nih.gov/17256833 DMYD4PC DI DMYD4PC DMYD4PC DN N-(4-Phenyl-pyridin-2-yl)-guanidine DMYD4PC MI TTXAGYU DMYD4PC MN Tissue-type plasminogen activator (PLAT) DMYD4PC MT DTT DMYD4PC MA Inhibitor DMYD4PC RN Selective urokinase-type plasminogen activator (uPA) inhibitors. Part 1: 2-Pyridinylguanidines. Bioorg Med Chem Lett. 2002 Jan 21;12(2):181-4. DMYD4PC RU https://pubmed.ncbi.nlm.nih.gov/11755349 DMQS9OH DI DMQS9OH DMQS9OH DN N-(4-phenylsulfamoyl-naphthalen-1-yl)-benzamide DMQS9OH MI TTE836A DMQS9OH MN C-C chemokine receptor type 8 (CCR8) DMQS9OH MT DTT DMQS9OH MA Inhibitor DMQS9OH RN Design, synthesis, and evaluation of naphthalene-sulfonamide antagonists of human CCR8. J Med Chem. 2007 Feb 8;50(3):566-84. DMQS9OH RU https://pubmed.ncbi.nlm.nih.gov/17266208 DMPA91F DI DMPA91F DMPA91F DN N-(4-Phenyl-thiazol-2-yl)-benzamide DMPA91F MI TTK25J1 DMPA91F MN Adenosine A1 receptor (ADORA1) DMPA91F MT DTT DMPA91F MA Inhibitor DMPA91F RN Substituted 4-phenyl-2-(phenylcarboxamido)-1,3-thiazole derivatives as antagonists for the adenosine A(1) receptor. Bioorg Med Chem Lett. 2001 Aug 6;11(15):2017-9. DMPA91F RU https://pubmed.ncbi.nlm.nih.gov/11454470 DM2OHVJ DI DM2OHVJ DM2OHVJ DN N-(4-Phenylthiazol-2-yl)isonicotinamide DM2OHVJ MI TTVDSZ0 DM2OHVJ MN Poly [ADP-ribose] polymerase 1 (PARP1) DM2OHVJ MT DTT DM2OHVJ MA Inhibitor DM2OHVJ RN Design, synthesis, and cytoprotective effect of 2-aminothiazole analogues as potent poly(ADP-ribose) polymerase-1 inhibitors. J Med Chem. 2009 Feb 12;52(3):718-25. DM2OHVJ RU https://pubmed.ncbi.nlm.nih.gov/19125579 DMG9D7A DI DMG9D7A DMG9D7A DN N-(4-Propylaminobutyl)-4-biphenylcarboxamide DMG9D7A MI TTZFYLI DMG9D7A MN Dopamine D1 receptor (D1R) DMG9D7A MT DTT DMG9D7A MA Inhibitor DMG9D7A RN Novel D3 selective dopaminergics incorporating enyne units as nonaromatic catechol bioisosteres: synthesis, bioactivity, and mutagenesis studies. J Med Chem. 2008 Nov 13;51(21):6829-38. DMG9D7A RU https://pubmed.ncbi.nlm.nih.gov/18834111 DMG9D7A DI DMG9D7A DMG9D7A DN N-(4-Propylaminobutyl)-4-biphenylcarboxamide DMG9D7A MI TT4C8EA DMG9D7A MN Dopamine D3 receptor (D3R) DMG9D7A MT DTT DMG9D7A MA Inhibitor DMG9D7A RN Novel D3 selective dopaminergics incorporating enyne units as nonaromatic catechol bioisosteres: synthesis, bioactivity, and mutagenesis studies. J Med Chem. 2008 Nov 13;51(21):6829-38. DMG9D7A RU https://pubmed.ncbi.nlm.nih.gov/18834111 DMG9D7A DI DMG9D7A DMG9D7A DN N-(4-Propylaminobutyl)-4-biphenylcarboxamide DMG9D7A MI TTE0A2F DMG9D7A MN Dopamine D4 receptor (D4R) DMG9D7A MT DTT DMG9D7A MA Inhibitor DMG9D7A RN Novel D3 selective dopaminergics incorporating enyne units as nonaromatic catechol bioisosteres: synthesis, bioactivity, and mutagenesis studies. J Med Chem. 2008 Nov 13;51(21):6829-38. DMG9D7A RU https://pubmed.ncbi.nlm.nih.gov/18834111 DMHBWM9 DI DMHBWM9 DMHBWM9 DN N-(4-Pyridin-2-yl-thiazol-2-yl)-benzamide DMHBWM9 MI TTM2AOE DMHBWM9 MN Adenosine A2a receptor (ADORA2A) DMHBWM9 MT DTT DMHBWM9 MA Inhibitor DMHBWM9 RN Thiazole and thiadiazole analogues as a novel class of adenosine receptor antagonists. J Med Chem. 2001 Mar 1;44(5):749-62. DMHBWM9 RU https://pubmed.ncbi.nlm.nih.gov/11262085 DMOMYDV DI DMOMYDV DMOMYDV DN N-(4-sulfamoylphenyl)-1H-indazole-3-carboxamide DMOMYDV MI TT7HF4W DMOMYDV MN Cyclin-dependent kinase 2 (CDK2) DMOMYDV MT DTT DMOMYDV MA Inhibitor DMOMYDV RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DMOMYDV RU https://pubmed.ncbi.nlm.nih.gov/10592235 DMZDACT DI DMZDACT DMZDACT DN N-(4-Sulfamoyl-phenyl)-benzamide DMZDACT MI TTHQPL7 DMZDACT MN Carbonic anhydrase I (CA-I) DMZDACT MT DTT DMZDACT MA Inhibitor DMZDACT RN Carbonic anhydrase inhibitors: inhibition of the tumor-associated isozymes IX and XII with a library of aromatic and heteroaromatic sulfonamides. Bioorg Med Chem Lett. 2005 Nov 1;15(21):4862-6. DMZDACT RU https://pubmed.ncbi.nlm.nih.gov/16168653 DMZDACT DI DMZDACT DMZDACT DN N-(4-Sulfamoyl-phenyl)-benzamide DMZDACT MI TTANPDJ DMZDACT MN Carbonic anhydrase II (CA-II) DMZDACT MT DTT DMZDACT MA Inhibitor DMZDACT RN Carbonic anhydrase inhibitors: inhibition of the tumor-associated isozymes IX and XII with a library of aromatic and heteroaromatic sulfonamides. Bioorg Med Chem Lett. 2005 Nov 1;15(21):4862-6. DMZDACT RU https://pubmed.ncbi.nlm.nih.gov/16168653 DMZDACT DI DMZDACT DMZDACT DN N-(4-Sulfamoyl-phenyl)-benzamide DMZDACT MI TT2LVK8 DMZDACT MN Carbonic anhydrase IX (CA-IX) DMZDACT MT DTT DMZDACT MA Inhibitor DMZDACT RN Carbonic anhydrase inhibitors: inhibition of the tumor-associated isozymes IX and XII with a library of aromatic and heteroaromatic sulfonamides. Bioorg Med Chem Lett. 2005 Nov 1;15(21):4862-6. DMZDACT RU https://pubmed.ncbi.nlm.nih.gov/16168653 DMZDACT DI DMZDACT DMZDACT DN N-(4-Sulfamoyl-phenyl)-benzamide DMZDACT MI TTSYM0R DMZDACT MN Carbonic anhydrase XII (CA-XII) DMZDACT MT DTT DMZDACT MA Inhibitor DMZDACT RN Carbonic anhydrase inhibitors: inhibition of the tumor-associated isozymes IX and XII with a library of aromatic and heteroaromatic sulfonamides. Bioorg Med Chem Lett. 2005 Nov 1;15(21):4862-6. DMZDACT RU https://pubmed.ncbi.nlm.nih.gov/16168653 DM3FW9Q DI DM3FW9Q DM3FW9Q DN N-(4-Sulfamoyl-phenyl)-butyramide DM3FW9Q MI TTHQPL7 DM3FW9Q MN Carbonic anhydrase I (CA-I) DM3FW9Q MT DTT DM3FW9Q MA Inhibitor DM3FW9Q RN Carbonic anhydrase inhibitors: inhibition of the tumor-associated isozymes IX and XII with a library of aromatic and heteroaromatic sulfonamides. Bioorg Med Chem Lett. 2005 Nov 1;15(21):4862-6. DM3FW9Q RU https://pubmed.ncbi.nlm.nih.gov/16168653 DM3FW9Q DI DM3FW9Q DM3FW9Q DN N-(4-Sulfamoyl-phenyl)-butyramide DM3FW9Q MI TTANPDJ DM3FW9Q MN Carbonic anhydrase II (CA-II) DM3FW9Q MT DTT DM3FW9Q MA Inhibitor DM3FW9Q RN Carbonic anhydrase inhibitors: inhibition of the tumor-associated isozymes IX and XII with a library of aromatic and heteroaromatic sulfonamides. Bioorg Med Chem Lett. 2005 Nov 1;15(21):4862-6. DM3FW9Q RU https://pubmed.ncbi.nlm.nih.gov/16168653 DM3FW9Q DI DM3FW9Q DM3FW9Q DN N-(4-Sulfamoyl-phenyl)-butyramide DM3FW9Q MI TT2LVK8 DM3FW9Q MN Carbonic anhydrase IX (CA-IX) DM3FW9Q MT DTT DM3FW9Q MA Inhibitor DM3FW9Q RN Carbonic anhydrase inhibitors: inhibition of the tumor-associated isozymes IX and XII with a library of aromatic and heteroaromatic sulfonamides. Bioorg Med Chem Lett. 2005 Nov 1;15(21):4862-6. DM3FW9Q RU https://pubmed.ncbi.nlm.nih.gov/16168653 DM3FW9Q DI DM3FW9Q DM3FW9Q DN N-(4-Sulfamoyl-phenyl)-butyramide DM3FW9Q MI TTSYM0R DM3FW9Q MN Carbonic anhydrase XII (CA-XII) DM3FW9Q MT DTT DM3FW9Q MA Inhibitor DM3FW9Q RN Carbonic anhydrase inhibitors: inhibition of the tumor-associated isozymes IX and XII with a library of aromatic and heteroaromatic sulfonamides. Bioorg Med Chem Lett. 2005 Nov 1;15(21):4862-6. DM3FW9Q RU https://pubmed.ncbi.nlm.nih.gov/16168653 DMJCXYQ DI DMJCXYQ DMJCXYQ DN N-(4-Sulfamoyl-phenyl)-isobutyramide DMJCXYQ MI TTANPDJ DMJCXYQ MN Carbonic anhydrase II (CA-II) DMJCXYQ MT DTT DMJCXYQ MA Inhibitor DMJCXYQ RN Carbonic anhydrase inhibitors: inhibition of the tumor-associated isozymes IX and XII with a library of aromatic and heteroaromatic sulfonamides. Bioorg Med Chem Lett. 2005 Nov 1;15(21):4862-6. DMJCXYQ RU https://pubmed.ncbi.nlm.nih.gov/16168653 DMJCXYQ DI DMJCXYQ DMJCXYQ DN N-(4-Sulfamoyl-phenyl)-isobutyramide DMJCXYQ MI TT2LVK8 DMJCXYQ MN Carbonic anhydrase IX (CA-IX) DMJCXYQ MT DTT DMJCXYQ MA Inhibitor DMJCXYQ RN Carbonic anhydrase inhibitors: inhibition of the tumor-associated isozymes IX and XII with a library of aromatic and heteroaromatic sulfonamides. Bioorg Med Chem Lett. 2005 Nov 1;15(21):4862-6. DMJCXYQ RU https://pubmed.ncbi.nlm.nih.gov/16168653 DMJCXYQ DI DMJCXYQ DMJCXYQ DN N-(4-Sulfamoyl-phenyl)-isobutyramide DMJCXYQ MI TTSYM0R DMJCXYQ MN Carbonic anhydrase XII (CA-XII) DMJCXYQ MT DTT DMJCXYQ MA Inhibitor DMJCXYQ RN Carbonic anhydrase inhibitors: inhibition of the tumor-associated isozymes IX and XII with a library of aromatic and heteroaromatic sulfonamides. Bioorg Med Chem Lett. 2005 Nov 1;15(21):4862-6. DMJCXYQ RU https://pubmed.ncbi.nlm.nih.gov/16168653 DM7MHQD DI DM7MHQD DM7MHQD DN N-(4-Sulfamoyl-phenyl)-propionamide DM7MHQD MI TTHQPL7 DM7MHQD MN Carbonic anhydrase I (CA-I) DM7MHQD MT DTT DM7MHQD MA Inhibitor DM7MHQD RN Carbonic anhydrase inhibitors: inhibition of the tumor-associated isozymes IX and XII with a library of aromatic and heteroaromatic sulfonamides. Bioorg Med Chem Lett. 2005 Nov 1;15(21):4862-6. DM7MHQD RU https://pubmed.ncbi.nlm.nih.gov/16168653 DM7MHQD DI DM7MHQD DM7MHQD DN N-(4-Sulfamoyl-phenyl)-propionamide DM7MHQD MI TTANPDJ DM7MHQD MN Carbonic anhydrase II (CA-II) DM7MHQD MT DTT DM7MHQD MA Inhibitor DM7MHQD RN Carbonic anhydrase inhibitors: inhibition of the tumor-associated isozymes IX and XII with a library of aromatic and heteroaromatic sulfonamides. Bioorg Med Chem Lett. 2005 Nov 1;15(21):4862-6. DM7MHQD RU https://pubmed.ncbi.nlm.nih.gov/16168653 DM7MHQD DI DM7MHQD DM7MHQD DN N-(4-Sulfamoyl-phenyl)-propionamide DM7MHQD MI TT2LVK8 DM7MHQD MN Carbonic anhydrase IX (CA-IX) DM7MHQD MT DTT DM7MHQD MA Inhibitor DM7MHQD RN Carbonic anhydrase inhibitors: inhibition of the tumor-associated isozymes IX and XII with a library of aromatic and heteroaromatic sulfonamides. Bioorg Med Chem Lett. 2005 Nov 1;15(21):4862-6. DM7MHQD RU https://pubmed.ncbi.nlm.nih.gov/16168653 DM7MHQD DI DM7MHQD DM7MHQD DN N-(4-Sulfamoyl-phenyl)-propionamide DM7MHQD MI TTSYM0R DM7MHQD MN Carbonic anhydrase XII (CA-XII) DM7MHQD MT DTT DM7MHQD MA Inhibitor DM7MHQD RN Carbonic anhydrase inhibitors: inhibition of the tumor-associated isozymes IX and XII with a library of aromatic and heteroaromatic sulfonamides. Bioorg Med Chem Lett. 2005 Nov 1;15(21):4862-6. DM7MHQD RU https://pubmed.ncbi.nlm.nih.gov/16168653 DM7QX03 DI DM7QX03 DM7QX03 DN N-(4-sulfamoylphenylethyl)-4-sulfamoylbenzamide DM7QX03 MI TTHQPL7 DM7QX03 MN Carbonic anhydrase I (CA-I) DM7QX03 MT DTT DM7QX03 MA Inhibitor DM7QX03 RN Pteridine-sulfonamide conjugates as dual inhibitors of carbonic anhydrases and dihydrofolate reductase with potential antitumor activity. Bioorg Med Chem. 2010 Jul 15;18(14):5081-9. DM7QX03 RU https://pubmed.ncbi.nlm.nih.gov/20580561 DM7QX03 DI DM7QX03 DM7QX03 DN N-(4-sulfamoylphenylethyl)-4-sulfamoylbenzamide DM7QX03 MI TTANPDJ DM7QX03 MN Carbonic anhydrase II (CA-II) DM7QX03 MT DTT DM7QX03 MA Inhibitor DM7QX03 RN Pteridine-sulfonamide conjugates as dual inhibitors of carbonic anhydrases and dihydrofolate reductase with potential antitumor activity. Bioorg Med Chem. 2010 Jul 15;18(14):5081-9. DM7QX03 RU https://pubmed.ncbi.nlm.nih.gov/20580561 DM7QX03 DI DM7QX03 DM7QX03 DN N-(4-sulfamoylphenylethyl)-4-sulfamoylbenzamide DM7QX03 MI TT2LVK8 DM7QX03 MN Carbonic anhydrase IX (CA-IX) DM7QX03 MT DTT DM7QX03 MA Inhibitor DM7QX03 RN Pteridine-sulfonamide conjugates as dual inhibitors of carbonic anhydrases and dihydrofolate reductase with potential antitumor activity. Bioorg Med Chem. 2010 Jul 15;18(14):5081-9. DM7QX03 RU https://pubmed.ncbi.nlm.nih.gov/20580561 DMHX4F2 DI DMHX4F2 DMHX4F2 DN N-(4'-t-butyl-4-biphenylyl)urea DMHX4F2 MI TTBGTCW DMHX4F2 MN Kinesin spindle messenger RNA (KIF11 mRNA) DMHX4F2 MT DTT DMHX4F2 MA Inhibitor DMHX4F2 RN Novel ATP-competitive kinesin spindle protein inhibitors. J Med Chem. 2007 Oct 4;50(20):4939-52. DMHX4F2 RU https://pubmed.ncbi.nlm.nih.gov/17725339 DMN6DAZ DI DMN6DAZ DMN6DAZ DN N-(4-tert-butylphenyl)-4-(pyridin-2-yl)benzamide DMN6DAZ MI TTMI6F5 DMN6DAZ MN Transient receptor potential cation channel V1 (TRPV1) DMN6DAZ MT DTT DMN6DAZ MA Inhibitor DMN6DAZ RN From arylureas to biarylamides to aminoquinazolines: discovery of a novel, potent TRPV1 antagonist. Bioorg Med Chem Lett. 2006 Oct 1;16(19):5217-21. DMN6DAZ RU https://pubmed.ncbi.nlm.nih.gov/16870426 DMFUBQ8 DI DMFUBQ8 DMFUBQ8 DN N-(4-tert-butylthiazol-2-yl)-1H-indol-4-amine DMFUBQ8 MI TT7HQD0 DMFUBQ8 MN C-C chemokine receptor type 4 (CCR4) DMFUBQ8 MT DTT DMFUBQ8 MA Inhibitor DMFUBQ8 RN Optimization of 2-aminothiazole derivatives as CCR4 antagonists. Bioorg Med Chem Lett. 2006 May 15;16(10):2800-3. DMFUBQ8 RU https://pubmed.ncbi.nlm.nih.gov/16497499 DMMUX86 DI DMMUX86 DMMUX86 DN N-(4-tert-butylthiazol-2-yl)isoquinolin-5-amine DMMUX86 MI TT7HQD0 DMMUX86 MN C-C chemokine receptor type 4 (CCR4) DMMUX86 MT DTT DMMUX86 MA Inhibitor DMMUX86 RN Optimization of 2-aminothiazole derivatives as CCR4 antagonists. Bioorg Med Chem Lett. 2006 May 15;16(10):2800-3. DMMUX86 RU https://pubmed.ncbi.nlm.nih.gov/16497499 DMBMAKG DI DMBMAKG DMBMAKG DN N-(4-tert-butylthiazol-2-yl)quinolin-5-amine DMBMAKG MI TT7HQD0 DMBMAKG MN C-C chemokine receptor type 4 (CCR4) DMBMAKG MT DTT DMBMAKG MA Inhibitor DMBMAKG RN Optimization of 2-aminothiazole derivatives as CCR4 antagonists. Bioorg Med Chem Lett. 2006 May 15;16(10):2800-3. DMBMAKG RU https://pubmed.ncbi.nlm.nih.gov/16497499 DMEW3L0 DI DMEW3L0 DMEW3L0 DN N-(5,6-DIPHENYLFURO[2,3-D]PYRIMIDIN-4-YL)GLYCINE DMEW3L0 MI TTTU902 DMEW3L0 MN Checkpoint kinase-1 (CHK1) DMEW3L0 MT DTT DMEW3L0 MA Inhibitor DMEW3L0 RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DMEW3L0 RU https://pubmed.ncbi.nlm.nih.gov/10592235 DM47XR8 DI DM47XR8 DM47XR8 DN N-(5-Amino-6-oxo-heptyl)-acetamidine DM47XR8 MI TTZUFI5 DM47XR8 MN Nitric-oxide synthase brain (NOS1) DM47XR8 MT DTT DM47XR8 MA Inhibitor DM47XR8 RN Evaluation of pyrrolidin-2-imines and 1,3-thiazolidin-2-imines as inhibitors of nitric oxide synthase. Bioorg Med Chem Lett. 2004 Sep 6;14(17):4539-44. DM47XR8 RU https://pubmed.ncbi.nlm.nih.gov/15357988 DM47XR8 DI DM47XR8 DM47XR8 DN N-(5-Amino-6-oxo-heptyl)-acetamidine DM47XR8 MI TTCM4B3 DM47XR8 MN Nitric-oxide synthase endothelial (NOS3) DM47XR8 MT DTT DM47XR8 MA Inhibitor DM47XR8 RN Evaluation of pyrrolidin-2-imines and 1,3-thiazolidin-2-imines as inhibitors of nitric oxide synthase. Bioorg Med Chem Lett. 2004 Sep 6;14(17):4539-44. DM47XR8 RU https://pubmed.ncbi.nlm.nih.gov/15357988 DM47XR8 DI DM47XR8 DM47XR8 DN N-(5-Amino-6-oxo-heptyl)-acetamidine DM47XR8 MI TTF10I9 DM47XR8 MN Nitric-oxide synthase inducible (NOS2) DM47XR8 MT DTT DM47XR8 MA Inhibitor DM47XR8 RN Evaluation of pyrrolidin-2-imines and 1,3-thiazolidin-2-imines as inhibitors of nitric oxide synthase. Bioorg Med Chem Lett. 2004 Sep 6;14(17):4539-44. DM47XR8 RU https://pubmed.ncbi.nlm.nih.gov/15357988 DMTF8US DI DMTF8US DMTF8US DN N-(5-Benzoyl-4-phenylthiazol-2-yl)benzamide DMTF8US MI TTK25J1 DMTF8US MN Adenosine A1 receptor (ADORA1) DMTF8US MT DTT DMTF8US MA Inhibitor DMTF8US RN 2-Amino-5-benzoyl-4-phenylthiazoles: Development of potent and selective adenosine A1 receptor antagonists. Bioorg Med Chem. 2010 Mar 15;18(6):2195-2203. DMTF8US RU https://pubmed.ncbi.nlm.nih.gov/20188574 DMTF8US DI DMTF8US DMTF8US DN N-(5-Benzoyl-4-phenylthiazol-2-yl)benzamide DMTF8US MI TTM2AOE DMTF8US MN Adenosine A2a receptor (ADORA2A) DMTF8US MT DTT DMTF8US MA Inhibitor DMTF8US RN 2-Amino-5-benzoyl-4-phenylthiazoles: Development of potent and selective adenosine A1 receptor antagonists. Bioorg Med Chem. 2010 Mar 15;18(6):2195-2203. DMTF8US RU https://pubmed.ncbi.nlm.nih.gov/20188574 DMTF8US DI DMTF8US DMTF8US DN N-(5-Benzoyl-4-phenylthiazol-2-yl)benzamide DMTF8US MI TTJFY5U DMTF8US MN Adenosine A3 receptor (ADORA3) DMTF8US MT DTT DMTF8US MA Inhibitor DMTF8US RN 2-Amino-5-benzoyl-4-phenylthiazoles: Development of potent and selective adenosine A1 receptor antagonists. Bioorg Med Chem. 2010 Mar 15;18(6):2195-2203. DMTF8US RU https://pubmed.ncbi.nlm.nih.gov/20188574 DMGAITY DI DMGAITY DMGAITY DN N-(5-Benzyloxy-isoquinolin-1-yl)-guanidine DMGAITY MI TTXAGYU DMGAITY MN Tissue-type plasminogen activator (PLAT) DMGAITY MT DTT DMGAITY MA Inhibitor DMGAITY RN Selective urokinase-type plasminogen activator (uPA) inhibitors. Part 3: 1-isoquinolinylguanidines. Bioorg Med Chem Lett. 2004 Jun 21;14(12):3227-30. DMGAITY RU https://pubmed.ncbi.nlm.nih.gov/15149680 DMD5E8G DI DMD5E8G DMD5E8G DN N-(5-Bromo-quinoxalin-6-yl)-guanidine DMD5E8G MI TTNGILX DMD5E8G MN Adrenergic receptor alpha-1A (ADRA1A) DMD5E8G MT DTT DMD5E8G MA Inhibitor DMD5E8G RN Analogs of UK 14,304: Structural features responsible for alpha2 adrenoceptor activity, Bioorg. Med. Chem. Lett. 5(15):1745-1750 (1995). DMD5E8G RU http://www.sciencedirect.com/science/article/pii/0960894X95002955 DMD5E8G DI DMD5E8G DMD5E8G DN N-(5-Bromo-quinoxalin-6-yl)-guanidine DMD5E8G MI TTBRKXS DMD5E8G MN Adrenergic receptor alpha-1B (ADRA1B) DMD5E8G MT DTT DMD5E8G MA Inhibitor DMD5E8G RN Analogs of UK 14,304: Structural features responsible for alpha2 adrenoceptor activity, Bioorg. Med. Chem. Lett. 5(15):1745-1750 (1995). DMD5E8G RU http://www.sciencedirect.com/science/article/pii/0960894X95002955 DMD5E8G DI DMD5E8G DMD5E8G DN N-(5-Bromo-quinoxalin-6-yl)-guanidine DMD5E8G MI TT34BHT DMD5E8G MN Adrenergic receptor alpha-1D (ADRA1D) DMD5E8G MT DTT DMD5E8G MA Inhibitor DMD5E8G RN Analogs of UK 14,304: Structural features responsible for alpha2 adrenoceptor activity, Bioorg. Med. Chem. Lett. 5(15):1745-1750 (1995). DMD5E8G RU http://www.sciencedirect.com/science/article/pii/0960894X95002955 DMHZ256 DI DMHZ256 DMHZ256 DN N-(5-chloro-2-(phenylthio)phenyl)butyramide DMHZ256 MI TTRTKPV DMHZ256 MN Trypanosoma Trypanothione reductase (Trypano TPR) DMHZ256 MT DTT DMHZ256 MA Inhibitor DMHZ256 RN Antitrypanosomal, antileishmanial, and antimalarial activities of quaternary arylalkylammonium 2-amino-4-chlorophenyl phenyl sulfides, a new class ... J Med Chem. 2005 Dec 15;48(25):8087-97. DMHZ256 RU https://pubmed.ncbi.nlm.nih.gov/16335933 DM2TFJE DI DM2TFJE DM2TFJE DN N-(5-chlorobenzo[d]oxazol-2-yl)benzenesulfonamide DM2TFJE MI TTWHDVK DM2TFJE MN Fructose-1,6-bisphosphatase (FBP) DM2TFJE MT DTT DM2TFJE MA Inhibitor DM2TFJE RN Benzoxazole benzenesulfonamides as allosteric inhibitors of fructose-1,6-bisphosphatase. Bioorg Med Chem Lett. 2006 Apr 1;16(7):1807-10. DM2TFJE RU https://pubmed.ncbi.nlm.nih.gov/16446092 DM9JCD3 DI DM9JCD3 DM9JCD3 DN N-(5-Cyclopropyl-1h-Pyrazol-3-Yl)Benzamide DM9JCD3 MI TT7HF4W DM9JCD3 MN Cyclin-dependent kinase 2 (CDK2) DM9JCD3 MT DTT DM9JCD3 MA Inhibitor DM9JCD3 RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DM9JCD3 RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMNQDLC DI DMNQDLC DMNQDLC DN N-(5-ethyl-1,3,4-thiadiazol-2-yl)sulfamide DMNQDLC MI TTUNARX DMNQDLC MN Carbonic anhydrase (CA) DMNQDLC MT DTT DMNQDLC MA Inhibitor DMNQDLC RN Carbonic anhydrase inhibitors: 2-substituted-1,3,4-thiadiazole-5-sulfamides act as powerful and selective inhibitors of the mitochondrial isozymes ... Bioorg Med Chem Lett. 2008 Dec 15;18(24):6332-5. DMNQDLC RU https://pubmed.ncbi.nlm.nih.gov/18990571 DMNQDLC DI DMNQDLC DMNQDLC DN N-(5-ethyl-1,3,4-thiadiazol-2-yl)sulfamide DMNQDLC MI TTHQPL7 DMNQDLC MN Carbonic anhydrase I (CA-I) DMNQDLC MT DTT DMNQDLC MA Inhibitor DMNQDLC RN Carbonic anhydrase inhibitors: 2-substituted-1,3,4-thiadiazole-5-sulfamides act as powerful and selective inhibitors of the mitochondrial isozymes ... Bioorg Med Chem Lett. 2008 Dec 15;18(24):6332-5. DMNQDLC RU https://pubmed.ncbi.nlm.nih.gov/18990571 DMNQDLC DI DMNQDLC DMNQDLC DN N-(5-ethyl-1,3,4-thiadiazol-2-yl)sulfamide DMNQDLC MI TTANPDJ DMNQDLC MN Carbonic anhydrase II (CA-II) DMNQDLC MT DTT DMNQDLC MA Inhibitor DMNQDLC RN Carbonic anhydrase inhibitors: 2-substituted-1,3,4-thiadiazole-5-sulfamides act as powerful and selective inhibitors of the mitochondrial isozymes ... Bioorg Med Chem Lett. 2008 Dec 15;18(24):6332-5. DMNQDLC RU https://pubmed.ncbi.nlm.nih.gov/18990571 DMNQDLC DI DMNQDLC DMNQDLC DN N-(5-ethyl-1,3,4-thiadiazol-2-yl)sulfamide DMNQDLC MI TTZHA0O DMNQDLC MN Carbonic anhydrase IV (CA-IV) DMNQDLC MT DTT DMNQDLC MA Inhibitor DMNQDLC RN Carbonic anhydrase inhibitors: 2-substituted-1,3,4-thiadiazole-5-sulfamides act as powerful and selective inhibitors of the mitochondrial isozymes ... Bioorg Med Chem Lett. 2008 Dec 15;18(24):6332-5. DMNQDLC RU https://pubmed.ncbi.nlm.nih.gov/18990571 DMUHKYW DI DMUHKYW DMUHKYW DN N-(5-Hydroxycarbamoyl-pentyl)-4-methoxy-benzamide DMUHKYW MI TTBH0VX DMUHKYW MN Histone deacetylase (HDAC) DMUHKYW MT DTT DMUHKYW MA Inhibitor DMUHKYW RN Amide analogues of trichostatin A as inhibitors of histone deacetylase and inducers of terminal cell differentiation. J Med Chem. 1999 Nov 4;42(22):4669-79. DMUHKYW RU https://pubmed.ncbi.nlm.nih.gov/10579829 DMSUW7M DI DMSUW7M DMSUW7M DN N-(5-Hydroxycarbamoyl-pentyl)-4-nitro-benzamide DMSUW7M MI TTBH0VX DMSUW7M MN Histone deacetylase (HDAC) DMSUW7M MT DTT DMSUW7M MA Inhibitor DMSUW7M RN Inhibitors of human histone deacetylase: synthesis and enzyme and cellular activity of straight chain hydroxamates. J Med Chem. 2002 Feb 14;45(4):753-7. DMSUW7M RU https://pubmed.ncbi.nlm.nih.gov/11831887 DMSUW7M DI DMSUW7M DMSUW7M DN N-(5-Hydroxycarbamoyl-pentyl)-4-nitro-benzamide DMSUW7M MI TT6R7JZ DMSUW7M MN Histone deacetylase 1 (HDAC1) DMSUW7M MT DTT DMSUW7M MA Inhibitor DMSUW7M RN Histone deacetylase inhibitors. J Med Chem. 2003 Nov 20;46(24):5097-116. DMSUW7M RU https://pubmed.ncbi.nlm.nih.gov/14613312 DMSUW7M DI DMSUW7M DMSUW7M DN N-(5-Hydroxycarbamoyl-pentyl)-4-nitro-benzamide DMSUW7M MI TTYHPU6 DMSUW7M MN Histone deacetylase 10 (HDAC10) DMSUW7M MT DTT DMSUW7M MA Inhibitor DMSUW7M RN Inhibitors of human histone deacetylase: synthesis and enzyme and cellular activity of straight chain hydroxamates. J Med Chem. 2002 Feb 14;45(4):753-7. DMSUW7M RU https://pubmed.ncbi.nlm.nih.gov/11831887 DMSUW7M DI DMSUW7M DMSUW7M DN N-(5-Hydroxycarbamoyl-pentyl)-4-nitro-benzamide DMSUW7M MI TTSHTOI DMSUW7M MN Histone deacetylase 2 (HDAC2) DMSUW7M MT DTT DMSUW7M MA Inhibitor DMSUW7M RN Histone deacetylase inhibitors. J Med Chem. 2003 Nov 20;46(24):5097-116. DMSUW7M RU https://pubmed.ncbi.nlm.nih.gov/14613312 DMSUW7M DI DMSUW7M DMSUW7M DN N-(5-Hydroxycarbamoyl-pentyl)-4-nitro-benzamide DMSUW7M MI TTTQGH8 DMSUW7M MN Histone deacetylase 4 (HDAC4) DMSUW7M MT DTT DMSUW7M MA Inhibitor DMSUW7M RN Histone deacetylase inhibitors. J Med Chem. 2003 Nov 20;46(24):5097-116. DMSUW7M RU https://pubmed.ncbi.nlm.nih.gov/14613312 DMSUW7M DI DMSUW7M DMSUW7M DN N-(5-Hydroxycarbamoyl-pentyl)-4-nitro-benzamide DMSUW7M MI TT5ZKDI DMSUW7M MN Histone deacetylase 6 (HDAC6) DMSUW7M MT DTT DMSUW7M MA Inhibitor DMSUW7M RN Histone deacetylase inhibitors. J Med Chem. 2003 Nov 20;46(24):5097-116. DMSUW7M RU https://pubmed.ncbi.nlm.nih.gov/14613312 DMSUW7M DI DMSUW7M DMSUW7M DN N-(5-Hydroxycarbamoyl-pentyl)-4-nitro-benzamide DMSUW7M MI TTT6LFV DMSUW7M MN Histone deacetylase 8 (HDAC8) DMSUW7M MT DTT DMSUW7M MA Inhibitor DMSUW7M RN Inhibitors of human histone deacetylase: synthesis and enzyme and cellular activity of straight chain hydroxamates. J Med Chem. 2002 Feb 14;45(4):753-7. DMSUW7M RU https://pubmed.ncbi.nlm.nih.gov/11831887 DMZSGPB DI DMZSGPB DMZSGPB DN N-(5-Hydroxycarbamoyl-pentyl)-benzamide DMZSGPB MI TTBH0VX DMZSGPB MN Histone deacetylase (HDAC) DMZSGPB MT DTT DMZSGPB MA Inhibitor DMZSGPB RN Amide analogues of trichostatin A as inhibitors of histone deacetylase and inducers of terminal cell differentiation. J Med Chem. 1999 Nov 4;42(22):4669-79. DMZSGPB RU https://pubmed.ncbi.nlm.nih.gov/10579829 DMSQEXP DI DMSQEXP DMSQEXP DN N-(5-Mercapto-[1,3,4]thiadiazol-2-yl)-acetamide DMSQEXP MI TTHQPL7 DMSQEXP MN Carbonic anhydrase I (CA-I) DMSQEXP MT DTT DMSQEXP MA Inhibitor DMSQEXP RN Carbonic anhydrase inhibitors. Inhibition of the cytosolic and tumor-associated carbonic anhydrase isozymes I, II, and IX with a series of 1,3,4-th... Bioorg Med Chem Lett. 2005 May 2;15(9):2347-52. DMSQEXP RU https://pubmed.ncbi.nlm.nih.gov/15837323 DMSQEXP DI DMSQEXP DMSQEXP DN N-(5-Mercapto-[1,3,4]thiadiazol-2-yl)-acetamide DMSQEXP MI TTANPDJ DMSQEXP MN Carbonic anhydrase II (CA-II) DMSQEXP MT DTT DMSQEXP MA Inhibitor DMSQEXP RN Carbonic anhydrase inhibitors. Inhibition of the cytosolic and tumor-associated carbonic anhydrase isozymes I, II, and IX with a series of 1,3,4-th... Bioorg Med Chem Lett. 2005 May 2;15(9):2347-52. DMSQEXP RU https://pubmed.ncbi.nlm.nih.gov/15837323 DMSQEXP DI DMSQEXP DMSQEXP DN N-(5-Mercapto-[1,3,4]thiadiazol-2-yl)-acetamide DMSQEXP MI TT2LVK8 DMSQEXP MN Carbonic anhydrase IX (CA-IX) DMSQEXP MT DTT DMSQEXP MA Inhibitor DMSQEXP RN Carbonic anhydrase inhibitors. Inhibition of the cytosolic and tumor-associated carbonic anhydrase isozymes I, II, and IX with a series of 1,3,4-th... Bioorg Med Chem Lett. 2005 May 2;15(9):2347-52. DMSQEXP RU https://pubmed.ncbi.nlm.nih.gov/15837323 DM91463 DI DM91463 DM91463 DN N-(5-Methanesulfonyl-2-methyl-benzoyl)-guanidine DM91463 MI TTGSEFH DM91463 MN Sodium/hydrogen exchanger 1 (SLC9A1) DM91463 MT DTT DM91463 MA Inhibitor DM91463 RN (2-Methyl-5-(methylsulfonyl)benzoyl)guanidine Na+/H+ antiporter inhibitors. J Med Chem. 1997 Jun 20;40(13):2017-34. DM91463 RU https://pubmed.ncbi.nlm.nih.gov/9207943 DM91463 DI DM91463 DM91463 DN N-(5-Methanesulfonyl-2-methyl-benzoyl)-guanidine DM91463 MI TTFZVPO DM91463 MN Sodium/hydrogen exchanger 3 (SLC9A3) DM91463 MT DTT DM91463 MA Inhibitor DM91463 RN (2-Methyl-5-(methylsulfonyl)benzoyl)guanidine Na+/H+ antiporter inhibitors. J Med Chem. 1997 Jun 20;40(13):2017-34. DM91463 RU https://pubmed.ncbi.nlm.nih.gov/9207943 DM8PNKC DI DM8PNKC DM8PNKC DN N-(5-methylthiazol-2-yl)-2-phenylacetamide DM8PNKC MI TTSJ6Q4 DM8PNKC MN LOX-5 messenger RNA (ALOX5 mRNA) DM8PNKC MT DTT DM8PNKC MA Inhibitor DM8PNKC RN Identification of natural-product-derived inhibitors of 5-lipoxygenase activity by ligand-based virtual screening. J Med Chem. 2007 May 31;50(11):2640-6. DM8PNKC RU https://pubmed.ncbi.nlm.nih.gov/17461565 DMFI057 DI DMFI057 DMFI057 DN N-(5-methylthiazol-2-yl)benzamide DMFI057 MI TTSJ6Q4 DMFI057 MN LOX-5 messenger RNA (ALOX5 mRNA) DMFI057 MT DTT DMFI057 MA Inhibitor DMFI057 RN Identification of natural-product-derived inhibitors of 5-lipoxygenase activity by ligand-based virtual screening. J Med Chem. 2007 May 31;50(11):2640-6. DMFI057 RU https://pubmed.ncbi.nlm.nih.gov/17461565 DMS2X69 DI DMS2X69 DMS2X69 DN N-(5-m-Tolyl-furan-2-carbonyl)-guanidine DMS2X69 MI TTGSEFH DMS2X69 MN Sodium/hydrogen exchanger 1 (SLC9A1) DMS2X69 MT DTT DMS2X69 MA Inhibitor DMS2X69 RN (5-Arylfuran-2-ylcarbonyl)guanidines as cardioprotectives through the inhibition of Na+/H+ exchanger isoform-1. J Med Chem. 2005 Apr 21;48(8):2882-91. DMS2X69 RU https://pubmed.ncbi.nlm.nih.gov/15828827 DMFNZSL DI DMFNZSL DMFNZSL DN N-(5-o-Tolyl-furan-2-carbonyl)-guanidine DMFNZSL MI TTGSEFH DMFNZSL MN Sodium/hydrogen exchanger 1 (SLC9A1) DMFNZSL MT DTT DMFNZSL MA Inhibitor DMFNZSL RN (5-Arylfuran-2-ylcarbonyl)guanidines as cardioprotectives through the inhibition of Na+/H+ exchanger isoform-1. J Med Chem. 2005 Apr 21;48(8):2882-91. DMFNZSL RU https://pubmed.ncbi.nlm.nih.gov/15828827 DMA21WB DI DMA21WB DMA21WB DN N-(5-phenyl-1,3,4-thiadiazol-2-yl)sulfamide DMA21WB MI TTUNARX DMA21WB MN Carbonic anhydrase (CA) DMA21WB MT DTT DMA21WB MA Inhibitor DMA21WB RN Carbonic anhydrase inhibitors: 2-substituted-1,3,4-thiadiazole-5-sulfamides act as powerful and selective inhibitors of the mitochondrial isozymes ... Bioorg Med Chem Lett. 2008 Dec 15;18(24):6332-5. DMA21WB RU https://pubmed.ncbi.nlm.nih.gov/18990571 DMA21WB DI DMA21WB DMA21WB DN N-(5-phenyl-1,3,4-thiadiazol-2-yl)sulfamide DMA21WB MI TTHQPL7 DMA21WB MN Carbonic anhydrase I (CA-I) DMA21WB MT DTT DMA21WB MA Inhibitor DMA21WB RN Carbonic anhydrase inhibitors: 2-substituted-1,3,4-thiadiazole-5-sulfamides act as powerful and selective inhibitors of the mitochondrial isozymes ... Bioorg Med Chem Lett. 2008 Dec 15;18(24):6332-5. DMA21WB RU https://pubmed.ncbi.nlm.nih.gov/18990571 DMA21WB DI DMA21WB DMA21WB DN N-(5-phenyl-1,3,4-thiadiazol-2-yl)sulfamide DMA21WB MI TTANPDJ DMA21WB MN Carbonic anhydrase II (CA-II) DMA21WB MT DTT DMA21WB MA Inhibitor DMA21WB RN Carbonic anhydrase inhibitors: 2-substituted-1,3,4-thiadiazole-5-sulfamides act as powerful and selective inhibitors of the mitochondrial isozymes ... Bioorg Med Chem Lett. 2008 Dec 15;18(24):6332-5. DMA21WB RU https://pubmed.ncbi.nlm.nih.gov/18990571 DMA21WB DI DMA21WB DMA21WB DN N-(5-phenyl-1,3,4-thiadiazol-2-yl)sulfamide DMA21WB MI TTZHA0O DMA21WB MN Carbonic anhydrase IV (CA-IV) DMA21WB MT DTT DMA21WB MA Inhibitor DMA21WB RN Carbonic anhydrase inhibitors: 2-substituted-1,3,4-thiadiazole-5-sulfamides act as powerful and selective inhibitors of the mitochondrial isozymes ... Bioorg Med Chem Lett. 2008 Dec 15;18(24):6332-5. DMA21WB RU https://pubmed.ncbi.nlm.nih.gov/18990571 DMNU68D DI DMNU68D DMNU68D DN N-(5-Phenyl-furan-2-carbonyl)-guanidine DMNU68D MI TTGSEFH DMNU68D MN Sodium/hydrogen exchanger 1 (SLC9A1) DMNU68D MT DTT DMNU68D MA Inhibitor DMNU68D RN (5-Arylfuran-2-ylcarbonyl)guanidines as cardioprotectives through the inhibition of Na+/H+ exchanger isoform-1. J Med Chem. 2005 Apr 21;48(8):2882-91. DMNU68D RU https://pubmed.ncbi.nlm.nih.gov/15828827 DM3FCAI DI DM3FCAI DM3FCAI DN N-(5'-Phosphopyridoxyl)-D-Alanine DM3FCAI MI TT6TMZU DM3FCAI MN Mycobacterium Biosynthetic alanine racemase (MycB alr) DM3FCAI MT DTT DM3FCAI MA Inhibitor DM3FCAI RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DM3FCAI RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMDZ9BY DI DMDZ9BY DMDZ9BY DN N-(5-Sulfamoyl-[1,3,4]thiadiazol-2-yl)-benzamide DMDZ9BY MI TTZHA0O DMDZ9BY MN Carbonic anhydrase IV (CA-IV) DMDZ9BY MT DTT DMDZ9BY MA Inhibitor DMDZ9BY RN Carbonic anhydrase inhibitors: anticonvulsant sulfonamides incorporating valproyl and other lipophilic moieties. J Med Chem. 2002 Jan 17;45(2):312-20. DMDZ9BY RU https://pubmed.ncbi.nlm.nih.gov/11784136 DM5E7OC DI DM5E7OC DM5E7OC DN N-(5-tert-butyl-1,3,4-thiadiazol-2-yl)sulfamide DM5E7OC MI TTUNARX DM5E7OC MN Carbonic anhydrase (CA) DM5E7OC MT DTT DM5E7OC MA Inhibitor DM5E7OC RN Carbonic anhydrase inhibitors: 2-substituted-1,3,4-thiadiazole-5-sulfamides act as powerful and selective inhibitors of the mitochondrial isozymes ... Bioorg Med Chem Lett. 2008 Dec 15;18(24):6332-5. DM5E7OC RU https://pubmed.ncbi.nlm.nih.gov/18990571 DM5E7OC DI DM5E7OC DM5E7OC DN N-(5-tert-butyl-1,3,4-thiadiazol-2-yl)sulfamide DM5E7OC MI TTHQPL7 DM5E7OC MN Carbonic anhydrase I (CA-I) DM5E7OC MT DTT DM5E7OC MA Inhibitor DM5E7OC RN Carbonic anhydrase inhibitors: 2-substituted-1,3,4-thiadiazole-5-sulfamides act as powerful and selective inhibitors of the mitochondrial isozymes ... Bioorg Med Chem Lett. 2008 Dec 15;18(24):6332-5. DM5E7OC RU https://pubmed.ncbi.nlm.nih.gov/18990571 DM5E7OC DI DM5E7OC DM5E7OC DN N-(5-tert-butyl-1,3,4-thiadiazol-2-yl)sulfamide DM5E7OC MI TTANPDJ DM5E7OC MN Carbonic anhydrase II (CA-II) DM5E7OC MT DTT DM5E7OC MA Inhibitor DM5E7OC RN Carbonic anhydrase inhibitors: 2-substituted-1,3,4-thiadiazole-5-sulfamides act as powerful and selective inhibitors of the mitochondrial isozymes ... Bioorg Med Chem Lett. 2008 Dec 15;18(24):6332-5. DM5E7OC RU https://pubmed.ncbi.nlm.nih.gov/18990571 DM5E7OC DI DM5E7OC DM5E7OC DN N-(5-tert-butyl-1,3,4-thiadiazol-2-yl)sulfamide DM5E7OC MI TTZHA0O DM5E7OC MN Carbonic anhydrase IV (CA-IV) DM5E7OC MT DTT DM5E7OC MA Inhibitor DM5E7OC RN Carbonic anhydrase inhibitors: 2-substituted-1,3,4-thiadiazole-5-sulfamides act as powerful and selective inhibitors of the mitochondrial isozymes ... Bioorg Med Chem Lett. 2008 Dec 15;18(24):6332-5. DM5E7OC RU https://pubmed.ncbi.nlm.nih.gov/18990571 DMDCX5O DI DMDCX5O DMDCX5O DN N-(6-(2-chlorophenyl)-1H-indazol-3-yl)butyramide DMDCX5O MI TTRSMW9 DMDCX5O MN Glycogen synthase kinase-3 beta (GSK-3B) DMDCX5O MT DTT DMDCX5O MA Inhibitor DMDCX5O RN Rational design of potent GSK3beta inhibitors with selectivity for Cdk1 and Cdk2. Bioorg Med Chem Lett. 2010 Mar 15;20(6):1985-9. DMDCX5O RU https://pubmed.ncbi.nlm.nih.gov/20167481 DMKGBZA DI DMKGBZA DMKGBZA DN N-(6-(3-hydroxyphenyl)-1H-indazol-3-yl)butyramide DMKGBZA MI TTRSMW9 DMKGBZA MN Glycogen synthase kinase-3 beta (GSK-3B) DMKGBZA MT DTT DMKGBZA MA Inhibitor DMKGBZA RN Rational design of potent GSK3beta inhibitors with selectivity for Cdk1 and Cdk2. Bioorg Med Chem Lett. 2010 Mar 15;20(6):1985-9. DMKGBZA RU https://pubmed.ncbi.nlm.nih.gov/20167481 DMDQEZG DI DMDQEZG DMDQEZG DN N-(6-(4-aminophenyl)-1H-indazol-3-yl)butyramide DMDQEZG MI TTRSMW9 DMDQEZG MN Glycogen synthase kinase-3 beta (GSK-3B) DMDQEZG MT DTT DMDQEZG MA Inhibitor DMDQEZG RN Rational design of potent GSK3beta inhibitors with selectivity for Cdk1 and Cdk2. Bioorg Med Chem Lett. 2010 Mar 15;20(6):1985-9. DMDQEZG RU https://pubmed.ncbi.nlm.nih.gov/20167481 DMP7UZB DI DMP7UZB DMP7UZB DN N-(6-(4-CHLOROPHENYL)-7-(2,4-DICHLOROPHENYL)-2,2-DIMETHYL-3,4-DIHYDRO-2H-PYRANO[2,3-B]PYRIDIN-4-YL)-2-HYDROXYACETAMIDE (ENANTIOMERIC MIX) DMP7UZB MI TT6OEDT DMP7UZB MN Cannabinoid receptor 1 (CB1) DMP7UZB MT DTT DMP7UZB MA Inhibitor DMP7UZB RN Dihydro-pyrano[2,3-b]pyridines and tetrahydro-1,8-naphthyridines as CB1 receptor inverse agonists: synthesis, SAR and biological evaluation. Bioorg Med Chem Lett. 2010 Jun 15;20(12):3750-4. DMP7UZB RU https://pubmed.ncbi.nlm.nih.gov/20483606 DMP7UZB DI DMP7UZB DMP7UZB DN N-(6-(4-CHLOROPHENYL)-7-(2,4-DICHLOROPHENYL)-2,2-DIMETHYL-3,4-DIHYDRO-2H-PYRANO[2,3-B]PYRIDIN-4-YL)-2-HYDROXYACETAMIDE (ENANTIOMERIC MIX) DMP7UZB MI TTMSFAW DMP7UZB MN Cannabinoid receptor 2 (CB2) DMP7UZB MT DTT DMP7UZB MA Inhibitor DMP7UZB RN Dihydro-pyrano[2,3-b]pyridines and tetrahydro-1,8-naphthyridines as CB1 receptor inverse agonists: synthesis, SAR and biological evaluation. Bioorg Med Chem Lett. 2010 Jun 15;20(12):3750-4. DMP7UZB RU https://pubmed.ncbi.nlm.nih.gov/20483606 DMDPXUA DI DMDPXUA DMDPXUA DN N-(6-(4-CHLOROPHENYL)-7-(2,4-DICHLOROPHENYL)-2,2-DIMETHYL-3,4-DIHYDRO-2H-PYRANO[2,3-B]PYRIDIN-4-YL)-3-HYDROXY-2,2-DIMETHYLPROPANAMIDE (ENANTIOMERIC MIX) DMDPXUA MI TT6OEDT DMDPXUA MN Cannabinoid receptor 1 (CB1) DMDPXUA MT DTT DMDPXUA MA Inhibitor DMDPXUA RN Dihydro-pyrano[2,3-b]pyridines and tetrahydro-1,8-naphthyridines as CB1 receptor inverse agonists: synthesis, SAR and biological evaluation. Bioorg Med Chem Lett. 2010 Jun 15;20(12):3750-4. DMDPXUA RU https://pubmed.ncbi.nlm.nih.gov/20483606 DMDPXUA DI DMDPXUA DMDPXUA DN N-(6-(4-CHLOROPHENYL)-7-(2,4-DICHLOROPHENYL)-2,2-DIMETHYL-3,4-DIHYDRO-2H-PYRANO[2,3-B]PYRIDIN-4-YL)-3-HYDROXY-2,2-DIMETHYLPROPANAMIDE (ENANTIOMERIC MIX) DMDPXUA MI TTMSFAW DMDPXUA MN Cannabinoid receptor 2 (CB2) DMDPXUA MT DTT DMDPXUA MA Inhibitor DMDPXUA RN Dihydro-pyrano[2,3-b]pyridines and tetrahydro-1,8-naphthyridines as CB1 receptor inverse agonists: synthesis, SAR and biological evaluation. Bioorg Med Chem Lett. 2010 Jun 15;20(12):3750-4. DMDPXUA RU https://pubmed.ncbi.nlm.nih.gov/20483606 DMSX5DI DI DMSX5DI DMSX5DI DN N-(6-(4-CHLOROPHENYL)-7-(2,4-DICHLOROPHENYL)-2,2-DIMETHYL-3,4-DIHYDRO-2H-PYRANO[2,3-B]PYRIDIN-4-YL)-3-HYDROXYPROPANAMIDE (ENANTIOMERIC MIX) DMSX5DI MI TT6OEDT DMSX5DI MN Cannabinoid receptor 1 (CB1) DMSX5DI MT DTT DMSX5DI MA Inhibitor DMSX5DI RN Dihydro-pyrano[2,3-b]pyridines and tetrahydro-1,8-naphthyridines as CB1 receptor inverse agonists: synthesis, SAR and biological evaluation. Bioorg Med Chem Lett. 2010 Jun 15;20(12):3750-4. DMSX5DI RU https://pubmed.ncbi.nlm.nih.gov/20483606 DMSX5DI DI DMSX5DI DMSX5DI DN N-(6-(4-CHLOROPHENYL)-7-(2,4-DICHLOROPHENYL)-2,2-DIMETHYL-3,4-DIHYDRO-2H-PYRANO[2,3-B]PYRIDIN-4-YL)-3-HYDROXYPROPANAMIDE (ENANTIOMERIC MIX) DMSX5DI MI TTMSFAW DMSX5DI MN Cannabinoid receptor 2 (CB2) DMSX5DI MT DTT DMSX5DI MA Inhibitor DMSX5DI RN Dihydro-pyrano[2,3-b]pyridines and tetrahydro-1,8-naphthyridines as CB1 receptor inverse agonists: synthesis, SAR and biological evaluation. Bioorg Med Chem Lett. 2010 Jun 15;20(12):3750-4. DMSX5DI RU https://pubmed.ncbi.nlm.nih.gov/20483606 DMSX5DI DI DMSX5DI DMSX5DI DN N-(6-(4-CHLOROPHENYL)-7-(2,4-DICHLOROPHENYL)-2,2-DIMETHYL-3,4-DIHYDRO-2H-PYRANO[2,3-B]PYRIDIN-4-YL)-3-HYDROXYPROPANAMIDE (ENANTIOMERIC MIX) DMSX5DI MI TTQ6VDM DMSX5DI MN Voltage-gated potassium channel Kv11.1 (KCNH2) DMSX5DI MT DTT DMSX5DI MA Inhibitor DMSX5DI RN Dihydro-pyrano[2,3-b]pyridines and tetrahydro-1,8-naphthyridines as CB1 receptor inverse agonists: synthesis, SAR and biological evaluation. Bioorg Med Chem Lett. 2010 Jun 15;20(12):3750-4. DMSX5DI RU https://pubmed.ncbi.nlm.nih.gov/20483606 DM4M12J DI DM4M12J DM4M12J DN N-(6-(4-fluorophenyl)-1H-indazol-3-yl)butyramide DM4M12J MI TTRSMW9 DM4M12J MN Glycogen synthase kinase-3 beta (GSK-3B) DM4M12J MT DTT DM4M12J MA Inhibitor DM4M12J RN Rational design of potent GSK3beta inhibitors with selectivity for Cdk1 and Cdk2. Bioorg Med Chem Lett. 2010 Mar 15;20(6):1985-9. DM4M12J RU https://pubmed.ncbi.nlm.nih.gov/20167481 DM8JLR4 DI DM8JLR4 DM8JLR4 DN N-(6-(4-hydroxyphenyl)-1H-indazol-3-yl)butyramide DM8JLR4 MI TTRSMW9 DM8JLR4 MN Glycogen synthase kinase-3 beta (GSK-3B) DM8JLR4 MT DTT DM8JLR4 MA Inhibitor DM8JLR4 RN Rational design of potent GSK3beta inhibitors with selectivity for Cdk1 and Cdk2. Bioorg Med Chem Lett. 2010 Mar 15;20(6):1985-9. DM8JLR4 RU https://pubmed.ncbi.nlm.nih.gov/20167481 DMRGQTM DI DMRGQTM DMRGQTM DN N-(6-(furan-3-yl)-1H-indazol-3-yl)butyramide DMRGQTM MI TTRSMW9 DMRGQTM MN Glycogen synthase kinase-3 beta (GSK-3B) DMRGQTM MT DTT DMRGQTM MA Inhibitor DMRGQTM RN Rational design of potent GSK3beta inhibitors with selectivity for Cdk1 and Cdk2. Bioorg Med Chem Lett. 2010 Mar 15;20(6):1985-9. DMRGQTM RU https://pubmed.ncbi.nlm.nih.gov/20167481 DM3FOKL DI DM3FOKL DM3FOKL DN N-(6-(pyridin-3-yl)-1H-indazol-3-yl)butyramide DM3FOKL MI TTRSMW9 DM3FOKL MN Glycogen synthase kinase-3 beta (GSK-3B) DM3FOKL MT DTT DM3FOKL MA Inhibitor DM3FOKL RN Design of potent and selective GSK3beta inhibitors with acceptable safety profile and pharmacokinetics. Bioorg Med Chem Lett. 2010 Apr 1;20(7):2344-9. DM3FOKL RU https://pubmed.ncbi.nlm.nih.gov/20189807 DM4GRK8 DI DM4GRK8 DM4GRK8 DN N-(6-(pyridin-4-yl)-1H-indazol-3-yl)butyramide DM4GRK8 MI TTRSMW9 DM4GRK8 MN Glycogen synthase kinase-3 beta (GSK-3B) DM4GRK8 MT DTT DM4GRK8 MA Inhibitor DM4GRK8 RN Rational design of potent GSK3beta inhibitors with selectivity for Cdk1 and Cdk2. Bioorg Med Chem Lett. 2010 Mar 15;20(6):1985-9. DM4GRK8 RU https://pubmed.ncbi.nlm.nih.gov/20167481 DMNRSYP DI DMNRSYP DMNRSYP DN N-(6-(thiophen-3-yl)-1H-indazol-3-yl)butyramide DMNRSYP MI TTRSMW9 DMNRSYP MN Glycogen synthase kinase-3 beta (GSK-3B) DMNRSYP MT DTT DMNRSYP MA Inhibitor DMNRSYP RN Rational design of potent GSK3beta inhibitors with selectivity for Cdk1 and Cdk2. Bioorg Med Chem Lett. 2010 Mar 15;20(6):1985-9. DMNRSYP RU https://pubmed.ncbi.nlm.nih.gov/20167481 DMMHD9Z DI DMMHD9Z DMMHD9Z DN N-(6-(trifluoromethyl)-1H-indazol-3-yl)butyramide DMMHD9Z MI TTRSMW9 DMMHD9Z MN Glycogen synthase kinase-3 beta (GSK-3B) DMMHD9Z MT DTT DMMHD9Z MA Inhibitor DMMHD9Z RN Rational design of potent GSK3beta inhibitors with selectivity for Cdk1 and Cdk2. Bioorg Med Chem Lett. 2010 Mar 15;20(6):1985-9. DMMHD9Z RU https://pubmed.ncbi.nlm.nih.gov/20167481 DMHINE0 DI DMHINE0 DMHINE0 DN N(6)-cyclohexyladenosine DMHINE0 MI TTK25J1 DMHINE0 MN Adenosine A1 receptor (ADORA1) DMHINE0 MT DTT DMHINE0 MA Agonist DMHINE0 RN Structure-activity relationships for 2-substituted adenosines at A1 and A2 adenosine receptors. Pharmacology. 1993;46(2):91-100. DMHINE0 RU https://pubmed.ncbi.nlm.nih.gov/8441759 DMHINE0 DI DMHINE0 DMHINE0 DN N(6)-cyclohexyladenosine DMHINE0 MI TTNE7KG DMHINE0 MN Adenosine A2b receptor (ADORA2B) DMHINE0 MT DTT DMHINE0 MA Agonist DMHINE0 RN Adenosine receptor activation in human fibroblasts: nucleoside agonists and antagonists. Can J Physiol Pharmacol. 1980 Jun;58(6):673-91. DMHINE0 RU https://pubmed.ncbi.nlm.nih.gov/6253037 DMHINE0 DI DMHINE0 DMHINE0 DN N(6)-cyclohexyladenosine DMHINE0 MI TTJFY5U DMHINE0 MN Adenosine A3 receptor (ADORA3) DMHINE0 MT DTT DMHINE0 MA Agonist DMHINE0 RN Inhibition of TNF-alpha expression by adenosine: role of A3 adenosine receptors. J Immunol. 1996 May 1;156(9):3435-42. DMHINE0 RU https://pubmed.ncbi.nlm.nih.gov/8617970 DMKWYMP DI DMKWYMP DMKWYMP DN N-(6)-methyl-2'-deoxyadenosine-3',5'-bisphosphate DMKWYMP MI TTA93TL DMKWYMP MN P2Y purinoceptor 1 (P2RY1) DMKWYMP MT DTT DMKWYMP MA Antagonist DMKWYMP RN Key role of the P2Y(1) receptor in tissue factor-induced thrombin-dependent acute thromboembolism: studies in P2Y(1)-knockout mice and mice treated with a P2Y(1) antagonist. Circulation. 2001 Feb 6;103(5):718-23. DMKWYMP RU https://pubmed.ncbi.nlm.nih.gov/11156884 DM0OCLU DI DM0OCLU DM0OCLU DN N-(6-benzyl-1H-indazol-3-yl)butyramide DM0OCLU MI TTRSMW9 DM0OCLU MN Glycogen synthase kinase-3 beta (GSK-3B) DM0OCLU MT DTT DM0OCLU MA Inhibitor DM0OCLU RN Rational design of potent GSK3beta inhibitors with selectivity for Cdk1 and Cdk2. Bioorg Med Chem Lett. 2010 Mar 15;20(6):1985-9. DM0OCLU RU https://pubmed.ncbi.nlm.nih.gov/20167481 DMJPL7E DI DMJPL7E DMJPL7E DN N-(6-bromo-1H-indazol-3-yl)butyramide DMJPL7E MI TTRSMW9 DMJPL7E MN Glycogen synthase kinase-3 beta (GSK-3B) DMJPL7E MT DTT DMJPL7E MA Inhibitor DMJPL7E RN Rational design of potent GSK3beta inhibitors with selectivity for Cdk1 and Cdk2. Bioorg Med Chem Lett. 2010 Mar 15;20(6):1985-9. DMJPL7E RU https://pubmed.ncbi.nlm.nih.gov/20167481 DMHGXPY DI DMHGXPY DMHGXPY DN N-(6-chloro-1H-indazol-3-yl)butyramide DMHGXPY MI TTRSMW9 DMHGXPY MN Glycogen synthase kinase-3 beta (GSK-3B) DMHGXPY MT DTT DMHGXPY MA Inhibitor DMHGXPY RN Rational design of potent GSK3beta inhibitors with selectivity for Cdk1 and Cdk2. Bioorg Med Chem Lett. 2010 Mar 15;20(6):1985-9. DMHGXPY RU https://pubmed.ncbi.nlm.nih.gov/20167481 DMJV3UO DI DMJV3UO DMJV3UO DN N-(6-chloro-5-phenyl-1H-indazol-3-yl)butyramide DMJV3UO MI TTRSMW9 DMJV3UO MN Glycogen synthase kinase-3 beta (GSK-3B) DMJV3UO MT DTT DMJV3UO MA Inhibitor DMJV3UO RN Design of potent and selective GSK3beta inhibitors with acceptable safety profile and pharmacokinetics. Bioorg Med Chem Lett. 2010 Apr 1;20(7):2344-9. DMJV3UO RU https://pubmed.ncbi.nlm.nih.gov/20189807 DMIN128 DI DMIN128 DMIN128 DN N-(6-chloro-5-p-tolyl-1H-indazol-3-yl)butyramide DMIN128 MI TTRSMW9 DMIN128 MN Glycogen synthase kinase-3 beta (GSK-3B) DMIN128 MT DTT DMIN128 MA Inhibitor DMIN128 RN Rational design of potent GSK3beta inhibitors with selectivity for Cdk1 and Cdk2. Bioorg Med Chem Lett. 2010 Mar 15;20(6):1985-9. DMIN128 RU https://pubmed.ncbi.nlm.nih.gov/20167481 DM90KGB DI DM90KGB DM90KGB DN N-(6-ethoxypyridin-2-yl)acetamide DM90KGB MI TT0K6EO DM90KGB MN Stress-activated protein kinase JNK1 (JNK1) DM90KGB MT DTT DM90KGB MA Inhibitor DM90KGB RN Aminopyridine-based c-Jun N-terminal kinase inhibitors with cellular activity and minimal cross-kinase activity. J Med Chem. 2006 Jun 15;49(12):3563-80. DM90KGB RU https://pubmed.ncbi.nlm.nih.gov/16759099 DMIZVMT DI DMIZVMT DMIZVMT DN N-(6-Hydroxycarbamoyl-hexyl)-benzamide DMIZVMT MI TTBH0VX DMIZVMT MN Histone deacetylase (HDAC) DMIZVMT MT DTT DMIZVMT MA Inhibitor DMIZVMT RN Inhibitors of human histone deacetylase: synthesis and enzyme and cellular activity of straight chain hydroxamates. J Med Chem. 2002 Feb 14;45(4):753-7. DMIZVMT RU https://pubmed.ncbi.nlm.nih.gov/11831887 DMIZVMT DI DMIZVMT DMIZVMT DN N-(6-Hydroxycarbamoyl-hexyl)-benzamide DMIZVMT MI TT6R7JZ DMIZVMT MN Histone deacetylase 1 (HDAC1) DMIZVMT MT DTT DMIZVMT MA Inhibitor DMIZVMT RN Inhibitors of human histone deacetylase: synthesis and enzyme and cellular activity of straight chain hydroxamates. J Med Chem. 2002 Feb 14;45(4):753-7. DMIZVMT RU https://pubmed.ncbi.nlm.nih.gov/11831887 DMIZVMT DI DMIZVMT DMIZVMT DN N-(6-Hydroxycarbamoyl-hexyl)-benzamide DMIZVMT MI TTYHPU6 DMIZVMT MN Histone deacetylase 10 (HDAC10) DMIZVMT MT DTT DMIZVMT MA Inhibitor DMIZVMT RN Inhibitors of human histone deacetylase: synthesis and enzyme and cellular activity of straight chain hydroxamates. J Med Chem. 2002 Feb 14;45(4):753-7. DMIZVMT RU https://pubmed.ncbi.nlm.nih.gov/11831887 DMIZVMT DI DMIZVMT DMIZVMT DN N-(6-Hydroxycarbamoyl-hexyl)-benzamide DMIZVMT MI TTSHTOI DMIZVMT MN Histone deacetylase 2 (HDAC2) DMIZVMT MT DTT DMIZVMT MA Inhibitor DMIZVMT RN Inhibitors of human histone deacetylase: synthesis and enzyme and cellular activity of straight chain hydroxamates. J Med Chem. 2002 Feb 14;45(4):753-7. DMIZVMT RU https://pubmed.ncbi.nlm.nih.gov/11831887 DMIZVMT DI DMIZVMT DMIZVMT DN N-(6-Hydroxycarbamoyl-hexyl)-benzamide DMIZVMT MI TTTQGH8 DMIZVMT MN Histone deacetylase 4 (HDAC4) DMIZVMT MT DTT DMIZVMT MA Inhibitor DMIZVMT RN Inhibitors of human histone deacetylase: synthesis and enzyme and cellular activity of straight chain hydroxamates. J Med Chem. 2002 Feb 14;45(4):753-7. DMIZVMT RU https://pubmed.ncbi.nlm.nih.gov/11831887 DMIZVMT DI DMIZVMT DMIZVMT DN N-(6-Hydroxycarbamoyl-hexyl)-benzamide DMIZVMT MI TT5ZKDI DMIZVMT MN Histone deacetylase 6 (HDAC6) DMIZVMT MT DTT DMIZVMT MA Inhibitor DMIZVMT RN Inhibitors of human histone deacetylase: synthesis and enzyme and cellular activity of straight chain hydroxamates. J Med Chem. 2002 Feb 14;45(4):753-7. DMIZVMT RU https://pubmed.ncbi.nlm.nih.gov/11831887 DMIZVMT DI DMIZVMT DMIZVMT DN N-(6-Hydroxycarbamoyl-hexyl)-benzamide DMIZVMT MI TTT6LFV DMIZVMT MN Histone deacetylase 8 (HDAC8) DMIZVMT MT DTT DMIZVMT MA Inhibitor DMIZVMT RN Inhibitors of human histone deacetylase: synthesis and enzyme and cellular activity of straight chain hydroxamates. J Med Chem. 2002 Feb 14;45(4):753-7. DMIZVMT RU https://pubmed.ncbi.nlm.nih.gov/11831887 DM01Y37 DI DM01Y37 DM01Y37 DN N-(6-Mercapto-hexyl)-benzamide DM01Y37 MI TTBH0VX DM01Y37 MN Histone deacetylase (HDAC) DM01Y37 MT DTT DM01Y37 MA Inhibitor DM01Y37 RN Novel inhibitors of human histone deacetylases: design, synthesis, enzyme inhibition, and cancer cell growth inhibition of SAHA-based non-hydroxama... J Med Chem. 2005 Feb 24;48(4):1019-32. DM01Y37 RU https://pubmed.ncbi.nlm.nih.gov/15715470 DM01Y37 DI DM01Y37 DM01Y37 DN N-(6-Mercapto-hexyl)-benzamide DM01Y37 MI TT6R7JZ DM01Y37 MN Histone deacetylase 1 (HDAC1) DM01Y37 MT DTT DM01Y37 MA Inhibitor DM01Y37 RN Novel inhibitors of human histone deacetylases: design, synthesis, enzyme inhibition, and cancer cell growth inhibition of SAHA-based non-hydroxama... J Med Chem. 2005 Feb 24;48(4):1019-32. DM01Y37 RU https://pubmed.ncbi.nlm.nih.gov/15715470 DM01Y37 DI DM01Y37 DM01Y37 DN N-(6-Mercapto-hexyl)-benzamide DM01Y37 MI TTYHPU6 DM01Y37 MN Histone deacetylase 10 (HDAC10) DM01Y37 MT DTT DM01Y37 MA Inhibitor DM01Y37 RN Novel inhibitors of human histone deacetylases: design, synthesis, enzyme inhibition, and cancer cell growth inhibition of SAHA-based non-hydroxama... J Med Chem. 2005 Feb 24;48(4):1019-32. DM01Y37 RU https://pubmed.ncbi.nlm.nih.gov/15715470 DM01Y37 DI DM01Y37 DM01Y37 DN N-(6-Mercapto-hexyl)-benzamide DM01Y37 MI TTSHTOI DM01Y37 MN Histone deacetylase 2 (HDAC2) DM01Y37 MT DTT DM01Y37 MA Inhibitor DM01Y37 RN Novel inhibitors of human histone deacetylases: design, synthesis, enzyme inhibition, and cancer cell growth inhibition of SAHA-based non-hydroxama... J Med Chem. 2005 Feb 24;48(4):1019-32. DM01Y37 RU https://pubmed.ncbi.nlm.nih.gov/15715470 DM01Y37 DI DM01Y37 DM01Y37 DN N-(6-Mercapto-hexyl)-benzamide DM01Y37 MI TTTQGH8 DM01Y37 MN Histone deacetylase 4 (HDAC4) DM01Y37 MT DTT DM01Y37 MA Inhibitor DM01Y37 RN Novel inhibitors of human histone deacetylases: design, synthesis, enzyme inhibition, and cancer cell growth inhibition of SAHA-based non-hydroxama... J Med Chem. 2005 Feb 24;48(4):1019-32. DM01Y37 RU https://pubmed.ncbi.nlm.nih.gov/15715470 DM01Y37 DI DM01Y37 DM01Y37 DN N-(6-Mercapto-hexyl)-benzamide DM01Y37 MI TT5ZKDI DM01Y37 MN Histone deacetylase 6 (HDAC6) DM01Y37 MT DTT DM01Y37 MA Inhibitor DM01Y37 RN Novel inhibitors of human histone deacetylases: design, synthesis, enzyme inhibition, and cancer cell growth inhibition of SAHA-based non-hydroxama... J Med Chem. 2005 Feb 24;48(4):1019-32. DM01Y37 RU https://pubmed.ncbi.nlm.nih.gov/15715470 DM01Y37 DI DM01Y37 DM01Y37 DN N-(6-Mercapto-hexyl)-benzamide DM01Y37 MI TTT6LFV DM01Y37 MN Histone deacetylase 8 (HDAC8) DM01Y37 MT DTT DM01Y37 MA Inhibitor DM01Y37 RN Novel inhibitors of human histone deacetylases: design, synthesis, enzyme inhibition, and cancer cell growth inhibition of SAHA-based non-hydroxama... J Med Chem. 2005 Feb 24;48(4):1019-32. DM01Y37 RU https://pubmed.ncbi.nlm.nih.gov/15715470 DMQRE5D DI DMQRE5D DMQRE5D DN N-(6-methylpyridin-2-yl)-5-phenylpicolinamide DMQRE5D MI TTHS256 DMQRE5D MN Metabotropic glutamate receptor 5 (mGluR5) DMQRE5D MT DTT DMQRE5D MA Inhibitor DMQRE5D RN Design and synthesis of novel heterobiaryl amides as metabotropic glutamate receptor subtype 5 antagonists. Bioorg Med Chem Lett. 2007 Apr 1;17(7):2074-9. DMQRE5D RU https://pubmed.ncbi.nlm.nih.gov/17336520 DMQZMRG DI DMQZMRG DMQZMRG DN N-(6-methylpyridin-2-yl)-6-phenylnicotinamide DMQZMRG MI TTHS256 DMQZMRG MN Metabotropic glutamate receptor 5 (mGluR5) DMQZMRG MT DTT DMQZMRG MA Inhibitor DMQZMRG RN Structure-activity relationships comparing N-(6-methylpyridin-yl)-substituted aryl amides to 2-methyl-6-(substituted-arylethynyl)pyridines or 2-met... J Med Chem. 2009 Jun 11;52(11):3563-75. DMQZMRG RU https://pubmed.ncbi.nlm.nih.gov/19445453 DMBNJ2L DI DMBNJ2L DMBNJ2L DN N-(6-methylpyridin-2-yl)biphenyl-3-carboxamide DMBNJ2L MI TTHS256 DMBNJ2L MN Metabotropic glutamate receptor 5 (mGluR5) DMBNJ2L MT DTT DMBNJ2L MA Inhibitor DMBNJ2L RN Structure-activity relationships comparing N-(6-methylpyridin-yl)-substituted aryl amides to 2-methyl-6-(substituted-arylethynyl)pyridines or 2-met... J Med Chem. 2009 Jun 11;52(11):3563-75. DMBNJ2L RU https://pubmed.ncbi.nlm.nih.gov/19445453 DM9K4WP DI DM9K4WP DM9K4WP DN N-(6-phenethyl-1H-indazol-3-yl)butyramide DM9K4WP MI TTRSMW9 DM9K4WP MN Glycogen synthase kinase-3 beta (GSK-3B) DM9K4WP MT DTT DM9K4WP MA Inhibitor DM9K4WP RN Rational design of potent GSK3beta inhibitors with selectivity for Cdk1 and Cdk2. Bioorg Med Chem Lett. 2010 Mar 15;20(6):1985-9. DM9K4WP RU https://pubmed.ncbi.nlm.nih.gov/20167481 DM2E5OX DI DM2E5OX DM2E5OX DN N-(6-phenoxypyridin-3-yl)-1H-indole-3-carboxamide DM2E5OX MI TTWJBZ5 DM2E5OX MN 5-HT 2C receptor (HTR2C) DM2E5OX MT DTT DM2E5OX MA Inhibitor DM2E5OX RN Synthesis and structure-activity relationship of 1H-indole-3-carboxylic acid pyridine-3-ylamides: a novel series of 5-HT2C receptor antagonists. Bioorg Med Chem Lett. 2008 Jul 15;18(14):3844-7. DM2E5OX RU https://pubmed.ncbi.nlm.nih.gov/18602261 DMVCPLU DI DMVCPLU DMVCPLU DN N-(6-phenyl-1H-indazol-3-yl)butyramide DMVCPLU MI TTRSMW9 DMVCPLU MN Glycogen synthase kinase-3 beta (GSK-3B) DMVCPLU MT DTT DMVCPLU MA Inhibitor DMVCPLU RN Design of potent and selective GSK3beta inhibitors with acceptable safety profile and pharmacokinetics. Bioorg Med Chem Lett. 2010 Apr 1;20(7):2344-9. DMVCPLU RU https://pubmed.ncbi.nlm.nih.gov/20189807 DMO3Y0B DI DMO3Y0B DMO3Y0B DN N-(7-(2-CHLOROPHENYL)-6-(4-CHLOROPHENYL)-2,2-DIMETHYL-3,4-DIHYDRO-2H-PYRANO[2,3-B]PYRIDIN-4-YL)-2-HYDROXYACETAMIDE (ENANTIOMERIC MIX) DMO3Y0B MI TT6OEDT DMO3Y0B MN Cannabinoid receptor 1 (CB1) DMO3Y0B MT DTT DMO3Y0B MA Inhibitor DMO3Y0B RN Dihydro-pyrano[2,3-b]pyridines and tetrahydro-1,8-naphthyridines as CB1 receptor inverse agonists: synthesis, SAR and biological evaluation. Bioorg Med Chem Lett. 2010 Jun 15;20(12):3750-4. DMO3Y0B RU https://pubmed.ncbi.nlm.nih.gov/20483606 DMO3Y0B DI DMO3Y0B DMO3Y0B DN N-(7-(2-CHLOROPHENYL)-6-(4-CHLOROPHENYL)-2,2-DIMETHYL-3,4-DIHYDRO-2H-PYRANO[2,3-B]PYRIDIN-4-YL)-2-HYDROXYACETAMIDE (ENANTIOMERIC MIX) DMO3Y0B MI TTMSFAW DMO3Y0B MN Cannabinoid receptor 2 (CB2) DMO3Y0B MT DTT DMO3Y0B MA Inhibitor DMO3Y0B RN Dihydro-pyrano[2,3-b]pyridines and tetrahydro-1,8-naphthyridines as CB1 receptor inverse agonists: synthesis, SAR and biological evaluation. Bioorg Med Chem Lett. 2010 Jun 15;20(12):3750-4. DMO3Y0B RU https://pubmed.ncbi.nlm.nih.gov/20483606 DM5F27T DI DM5F27T DM5F27T DN N-(7'-(2-CHLOROPHENYL)-6'-(4-CHLOROPHENYL)-3',4'-DIHYDROSPIRO[CYCLOHEXANE-1,2'-PYRANO[2,3-B]PYRIDINE]-4'-YL)-2-HYDROXY-2-METHYLPROPANAMIDE (ENANTIOMERIC MIX) DM5F27T MI TT6OEDT DM5F27T MN Cannabinoid receptor 1 (CB1) DM5F27T MT DTT DM5F27T MA Inhibitor DM5F27T RN Dihydro-pyrano[2,3-b]pyridines and tetrahydro-1,8-naphthyridines as CB1 receptor inverse agonists: synthesis, SAR and biological evaluation. Bioorg Med Chem Lett. 2010 Jun 15;20(12):3750-4. DM5F27T RU https://pubmed.ncbi.nlm.nih.gov/20483606 DM5F27T DI DM5F27T DM5F27T DN N-(7'-(2-CHLOROPHENYL)-6'-(4-CHLOROPHENYL)-3',4'-DIHYDROSPIRO[CYCLOHEXANE-1,2'-PYRANO[2,3-B]PYRIDINE]-4'-YL)-2-HYDROXY-2-METHYLPROPANAMIDE (ENANTIOMERIC MIX) DM5F27T MI TTMSFAW DM5F27T MN Cannabinoid receptor 2 (CB2) DM5F27T MT DTT DM5F27T MA Inhibitor DM5F27T RN Dihydro-pyrano[2,3-b]pyridines and tetrahydro-1,8-naphthyridines as CB1 receptor inverse agonists: synthesis, SAR and biological evaluation. Bioorg Med Chem Lett. 2010 Jun 15;20(12):3750-4. DM5F27T RU https://pubmed.ncbi.nlm.nih.gov/20483606 DMPMBC2 DI DMPMBC2 DMPMBC2 DN N-(7-Benzyloxy-isoquinolin-1-yl)-guanidine DMPMBC2 MI TTXAGYU DMPMBC2 MN Tissue-type plasminogen activator (PLAT) DMPMBC2 MT DTT DMPMBC2 MA Inhibitor DMPMBC2 RN Selective urokinase-type plasminogen activator (uPA) inhibitors. Part 3: 1-isoquinolinylguanidines. Bioorg Med Chem Lett. 2004 Jun 21;14(12):3227-30. DMPMBC2 RU https://pubmed.ncbi.nlm.nih.gov/15149680 DMH42L8 DI DMH42L8 DMH42L8 DN N-(7-methoxy-4-phenylbenzofuran-2-yl)acetamide DMH42L8 MI TTM2AOE DMH42L8 MN Adenosine A2a receptor (ADORA2A) DMH42L8 MT DTT DMH42L8 MA Inhibitor DMH42L8 RN Synthetic studies on selective adenosine A2A receptor antagonists: synthesis and structure-activity relationships of novel benzofuran derivatives. Bioorg Med Chem Lett. 2010 Feb 1;20(3):1090-3. DMH42L8 RU https://pubmed.ncbi.nlm.nih.gov/20034788 DMHFPE3 DI DMHFPE3 DMHFPE3 DN N-(8-(3-cyanophenyl)-9H-purin-6-yl)pentanamide DMHFPE3 MI TTRSMW9 DMHFPE3 MN Glycogen synthase kinase-3 beta (GSK-3B) DMHFPE3 MT DTT DMHFPE3 MA Inhibitor DMHFPE3 RN Novel 8-arylated purines as inhibitors of glycogen synthase kinase. Eur J Med Chem. 2010 Aug;45(8):3389-93. DMHFPE3 RU https://pubmed.ncbi.nlm.nih.gov/20472330 DMBD52I DI DMBD52I DMBD52I DN N-(9H-beta-Carbolin-3-yl)-acetamide DMBD52I MI TT1MPAY DMBD52I MN GABA(A) receptor alpha-1 (GABRA1) DMBD52I MT DTT DMBD52I MA Inhibitor DMBD52I RN 3-Amino-beta-carboline derivatives and the benzodiazepine receptor. Synthesis of a selective antagonist of the sedative action of diazepam. J Med Chem. 1985 Jun;28(6):824-8. DMBD52I RU https://pubmed.ncbi.nlm.nih.gov/2989520 DMBD52I DI DMBD52I DMBD52I DN N-(9H-beta-Carbolin-3-yl)-acetamide DMBD52I MI TTNJYV2 DMBD52I MN Gamma-aminobutyric acid receptor (GAR) DMBD52I MT DTT DMBD52I MA Inhibitor DMBD52I RN 3-Amino-beta-carboline derivatives and the benzodiazepine receptor. Synthesis of a selective antagonist of the sedative action of diazepam. J Med Chem. 1985 Jun;28(6):824-8. DMBD52I RU https://pubmed.ncbi.nlm.nih.gov/2989520 DM3KNSY DI DM3KNSY DM3KNSY DN N-(9H-beta-Carbolin-3-yl)-formamide DM3KNSY MI TT1MPAY DM3KNSY MN GABA(A) receptor alpha-1 (GABRA1) DM3KNSY MT DTT DM3KNSY MA Inhibitor DM3KNSY RN 3-Amino-beta-carboline derivatives and the benzodiazepine receptor. Synthesis of a selective antagonist of the sedative action of diazepam. J Med Chem. 1985 Jun;28(6):824-8. DM3KNSY RU https://pubmed.ncbi.nlm.nih.gov/2989520 DM3KNSY DI DM3KNSY DM3KNSY DN N-(9H-beta-Carbolin-3-yl)-formamide DM3KNSY MI TTNJYV2 DM3KNSY MN Gamma-aminobutyric acid receptor (GAR) DM3KNSY MT DTT DM3KNSY MA Inhibitor DM3KNSY RN 3-Amino-beta-carboline derivatives and the benzodiazepine receptor. Synthesis of a selective antagonist of the sedative action of diazepam. J Med Chem. 1985 Jun;28(6):824-8. DM3KNSY RU https://pubmed.ncbi.nlm.nih.gov/2989520 DMFONC1 DI DMFONC1 DMFONC1 DN N-(Adamant-1-yl)-1'H-phenothiazine-1'-carboxamide DMFONC1 MI TTEB0GD DMFONC1 MN Cholinesterase (BCHE) DMFONC1 MT DTT DMFONC1 MA Inhibitor DMFONC1 RN Differential binding of phenothiazine urea derivatives to wild-type human cholinesterases and butyrylcholinesterase mutants. Bioorg Med Chem. 2010 Mar 15;18(6):2232-2244. DMFONC1 RU https://pubmed.ncbi.nlm.nih.gov/20181484 DM87YJW DI DM87YJW DM87YJW DN N-(benzyl),N-(pyrrol-2-ylmethyl)amine DM87YJW MI TT3WG5C DM87YJW MN Monoamine oxidase type A (MAO-A) DM87YJW MT DTT DM87YJW MA Inhibitor DM87YJW RN New pyrrole inhibitors of monoamine oxidase: synthesis, biological evaluation, and structural determinants of MAO-A and MAO-B selectivity. J Med Chem. 2007 Mar 8;50(5):922-31. DM87YJW RU https://pubmed.ncbi.nlm.nih.gov/17256833 DM87YJW DI DM87YJW DM87YJW DN N-(benzyl),N-(pyrrol-2-ylmethyl)amine DM87YJW MI TTGP7BY DM87YJW MN Monoamine oxidase type B (MAO-B) DM87YJW MT DTT DM87YJW MA Inhibitor DM87YJW RN New pyrrole inhibitors of monoamine oxidase: synthesis, biological evaluation, and structural determinants of MAO-A and MAO-B selectivity. J Med Chem. 2007 Mar 8;50(5):922-31. DM87YJW RU https://pubmed.ncbi.nlm.nih.gov/17256833 DMR18YI DI DMR18YI DMR18YI DN N-(benzyloxycarbonyl)-leucyl-glycine-nitrile DMR18YI MI TTDZN01 DMR18YI MN Cathepsin K (CTSK) DMR18YI MT DTT DMR18YI MA Inhibitor DMR18YI RN Interaction of papain-like cysteine proteases with dipeptide-derived nitriles. J Med Chem. 2005 Dec 1;48(24):7688-707. DMR18YI RU https://pubmed.ncbi.nlm.nih.gov/16302809 DMR18YI DI DMR18YI DMR18YI DN N-(benzyloxycarbonyl)-leucyl-glycine-nitrile DMR18YI MI TT36ETB DMR18YI MN Cathepsin L (CTSL) DMR18YI MT DTT DMR18YI MA Inhibitor DMR18YI RN Interaction of papain-like cysteine proteases with dipeptide-derived nitriles. J Med Chem. 2005 Dec 1;48(24):7688-707. DMR18YI RU https://pubmed.ncbi.nlm.nih.gov/16302809 DMR18YI DI DMR18YI DMR18YI DN N-(benzyloxycarbonyl)-leucyl-glycine-nitrile DMR18YI MI TTUMQVO DMR18YI MN Cathepsin S (CTSS) DMR18YI MT DTT DMR18YI MA Inhibitor DMR18YI RN Interaction of papain-like cysteine proteases with dipeptide-derived nitriles. J Med Chem. 2005 Dec 1;48(24):7688-707. DMR18YI RU https://pubmed.ncbi.nlm.nih.gov/16302809 DMRCYB8 DI DMRCYB8 DMRCYB8 DN N-(biphenyl-3-yl)-6-(sulfamoylamino)hexanamide DMRCYB8 MI TT5ZKDI DMRCYB8 MN Histone deacetylase 6 (HDAC6) DMRCYB8 MT DTT DMRCYB8 MA Inhibitor DMRCYB8 RN Sulfamides as novel histone deacetylase inhibitors. Bioorg Med Chem Lett. 2009 Jan 15;19(2):336-40. DMRCYB8 RU https://pubmed.ncbi.nlm.nih.gov/19084395 DM2ZQBS DI DM2ZQBS DM2ZQBS DN N-(biphenyl-3-yl)benzo[d]isoxazol-3-amine DM2ZQBS MI TT7WVHI DM2ZQBS MN Soluble epoxide hydrolase (EPHX2) DM2ZQBS MT DTT DM2ZQBS MA Inhibitor DM2ZQBS RN A strategy of employing aminoheterocycles as amide mimics to identify novel, potent and bioavailable soluble epoxide hydrolase inhibitors. Bioorg Med Chem Lett. 2009 Oct 1;19(19):5716-21. DM2ZQBS RU https://pubmed.ncbi.nlm.nih.gov/19700315 DMSO7FW DI DMSO7FW DMSO7FW DN N-(Biphenyl-4-yl)-2-cyano-3-hydroxybut-2-enamide DMSO7FW MI TT3PQ2Y DMSO7FW MN Plasmodium Dihydroorotate dehydrogenase (Malaria DHOdehase) DMSO7FW MT DTT DMSO7FW MA Inhibitor DMSO7FW RN Structure-based design, synthesis, and characterization of inhibitors of human and Plasmodium falciparum dihydroorotate dehydrogenases. J Med Chem. 2009 May 14;52(9):2683-93. DMSO7FW RU https://pubmed.ncbi.nlm.nih.gov/19351152 DML10NT DI DML10NT DML10NT DN N-(biphenyl-4-yl)benzo[d]isoxazol-3-amine DML10NT MI TT7WVHI DML10NT MN Soluble epoxide hydrolase (EPHX2) DML10NT MT DTT DML10NT MA Inhibitor DML10NT RN A strategy of employing aminoheterocycles as amide mimics to identify novel, potent and bioavailable soluble epoxide hydrolase inhibitors. Bioorg Med Chem Lett. 2009 Oct 1;19(19):5716-21. DML10NT RU https://pubmed.ncbi.nlm.nih.gov/19700315 DMHPITZ DI DMHPITZ DMHPITZ DN N-(biphenyl-4-ylsulfonyl)-D-leucine DMHPITZ MI TTXZ0KQ DMHPITZ MN Matrix metalloproteinase-12 (MMP-12) DMHPITZ MT DTT DMHPITZ MA Inhibitor DMHPITZ RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DMHPITZ RU https://pubmed.ncbi.nlm.nih.gov/10592235 DMFGSLO DI DMFGSLO DMFGSLO DN N-(Chlorophenyl)-N'-Hydroxyguanidine DMFGSLO MI TTCM4B3 DMFGSLO MN Nitric-oxide synthase endothelial (NOS3) DMFGSLO MT DTT DMFGSLO MA Inhibitor DMFGSLO RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DMFGSLO RU https://pubmed.ncbi.nlm.nih.gov/10592235 DM1TA5R DI DM1TA5R DM1TA5R DN N-(cis-9-cis-12-octadecadienyl)sulfamide DM1TA5R MI TT6OEDT DM1TA5R MN Cannabinoid receptor 1 (CB1) DM1TA5R MT DTT DM1TA5R MA Inhibitor DM1TA5R RN Synthesis and pharmacological evaluation of sulfamide-based analogues of anandamide. Eur J Med Chem. 2009 Dec;44(12):4889-95. DM1TA5R RU https://pubmed.ncbi.nlm.nih.gov/19762126 DMTKREZ DI DMTKREZ DMTKREZ DN N-(cyanomethyl)cyclohex-1-ene-1-carboxamide DMTKREZ MI TTDZN01 DMTKREZ MN Cathepsin K (CTSK) DMTKREZ MT DTT DMTKREZ MA Inhibitor DMTKREZ RN Beta-substituted cyclohexanecarboxamide: a nonpeptidic framework for the design of potent inhibitors of cathepsin K. J Med Chem. 2006 Feb 9;49(3):1066-79. DMTKREZ RU https://pubmed.ncbi.nlm.nih.gov/16451072 DMI245K DI DMI245K DMI245K DN N-(dibenzo[b,d]thiophen-3-ylsulfonyl)-L-valine DMI245K MI TTXZ0KQ DMI245K MN Matrix metalloproteinase-12 (MMP-12) DMI245K MT DTT DMI245K MA Inhibitor DMI245K RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DMI245K RU https://pubmed.ncbi.nlm.nih.gov/10592235 DMJ6U4H DI DMJ6U4H DMJ6U4H DN N-(Ethylphosphoryl)-L-isoleucyl-L-Trp-NHCH3 DMJ6U4H MI TTMX39J DMJ6U4H MN Matrix metalloproteinase-1 (MMP-1) DMJ6U4H MT DTT DMJ6U4H MA Inhibitor DMJ6U4H RN Phosphoramidate peptide inhibitors of human skin fibroblast collagenase. J Med Chem. 1990 Jan;33(1):263-73. DMJ6U4H RU https://pubmed.ncbi.nlm.nih.gov/2153207 DMLJZGD DI DMLJZGD DMLJZGD DN N-(furan-2-ylmethyl)estradiol-16-carboxamide DMLJZGD MI TTIWB6L DMLJZGD MN Estradiol 17 beta-dehydrogenase 1 (17-beta-HSD1) DMLJZGD MT DTT DMLJZGD MA Inhibitor DMLJZGD RN Modification of estrone at the 6, 16, and 17 positions: novel potent inhibitors of 17beta-hydroxysteroid dehydrogenase type 1. J Med Chem. 2006 Feb 23;49(4):1325-45. DMLJZGD RU https://pubmed.ncbi.nlm.nih.gov/16480268 DM0DZ9J DI DM0DZ9J DM0DZ9J DN N-(furan-2-ylmethyl)-estrone-16-methyl carboxamide DM0DZ9J MI TTIWB6L DM0DZ9J MN Estradiol 17 beta-dehydrogenase 1 (17-beta-HSD1) DM0DZ9J MT DTT DM0DZ9J MA Inhibitor DM0DZ9J RN Modification of estrone at the 6, 16, and 17 positions: novel potent inhibitors of 17beta-hydroxysteroid dehydrogenase type 1. J Med Chem. 2006 Feb 23;49(4):1325-45. DM0DZ9J RU https://pubmed.ncbi.nlm.nih.gov/16480268 DMW378C DI DMW378C DMW378C DN N-(naphthalen-1-yl)-4-neopentylthiazol-2-amine DMW378C MI TT7HQD0 DMW378C MN C-C chemokine receptor type 4 (CCR4) DMW378C MT DTT DMW378C MA Inhibitor DMW378C RN Optimization of 2-aminothiazole derivatives as CCR4 antagonists. Bioorg Med Chem Lett. 2006 May 15;16(10):2800-3. DMW378C RU https://pubmed.ncbi.nlm.nih.gov/16497499 DMFZPCD DI DMFZPCD DMFZPCD DN N-(naphthalen-1-yl)-4-phenylthiazol-2-amine DMFZPCD MI TT7HQD0 DMFZPCD MN C-C chemokine receptor type 4 (CCR4) DMFZPCD MT DTT DMFZPCD MA Inhibitor DMFZPCD RN Optimization of 2-aminothiazole derivatives as CCR4 antagonists. Bioorg Med Chem Lett. 2006 May 15;16(10):2800-3. DMFZPCD RU https://pubmed.ncbi.nlm.nih.gov/16497499 DM2CBNG DI DM2CBNG DM2CBNG DN N-(naphthalen-1-yl)benzo[d]isoxazol-3-amine DM2CBNG MI TT7WVHI DM2CBNG MN Soluble epoxide hydrolase (EPHX2) DM2CBNG MT DTT DM2CBNG MA Inhibitor DM2CBNG RN A strategy of employing aminoheterocycles as amide mimics to identify novel, potent and bioavailable soluble epoxide hydrolase inhibitors. Bioorg Med Chem Lett. 2009 Oct 1;19(19):5716-21. DM2CBNG RU https://pubmed.ncbi.nlm.nih.gov/19700315 DM2NHVX DI DM2NHVX DM2NHVX DN N-(naphthalen-2-yl)benzo[d]isoxazol-3-amine DM2NHVX MI TT7WVHI DM2NHVX MN Soluble epoxide hydrolase (EPHX2) DM2NHVX MT DTT DM2NHVX MA Inhibitor DM2NHVX RN A strategy of employing aminoheterocycles as amide mimics to identify novel, potent and bioavailable soluble epoxide hydrolase inhibitors. Bioorg Med Chem Lett. 2009 Oct 1;19(19):5716-21. DM2NHVX RU https://pubmed.ncbi.nlm.nih.gov/19700315 DMG8KXR DI DMG8KXR DMG8KXR DN N-(Naphthalene-2-yl)ethyl-ETAV DMG8KXR MI TT9PB26 DMG8KXR MN Presynaptic density protein 95 (DLG4) DMG8KXR MT DTT DMG8KXR MA Inhibitor DMG8KXR RN Modified peptides as potent inhibitors of the postsynaptic density-95/N-methyl-D-aspartate receptor interaction. J Med Chem. 2008 Oct 23;51(20):6450-9. DMG8KXR RU https://pubmed.ncbi.nlm.nih.gov/18811137 DME45J8 DI DME45J8 DME45J8 DN N-(pentafluorophenyl)sulfamide DME45J8 MI TTHQPL7 DME45J8 MN Carbonic anhydrase I (CA-I) DME45J8 MT DTT DME45J8 MA Inhibitor DME45J8 RN Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, IX, and XII with N-hydroxy... Bioorg Med Chem Lett. 2005 May 2;15(9):2353-8. DME45J8 RU https://pubmed.ncbi.nlm.nih.gov/15837324 DME45J8 DI DME45J8 DME45J8 DN N-(pentafluorophenyl)sulfamide DME45J8 MI TTANPDJ DME45J8 MN Carbonic anhydrase II (CA-II) DME45J8 MT DTT DME45J8 MA Inhibitor DME45J8 RN Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, IX, and XII with N-hydroxy... Bioorg Med Chem Lett. 2005 May 2;15(9):2353-8. DME45J8 RU https://pubmed.ncbi.nlm.nih.gov/15837324 DME45J8 DI DME45J8 DME45J8 DN N-(pentafluorophenyl)sulfamide DME45J8 MI TT2LVK8 DME45J8 MN Carbonic anhydrase IX (CA-IX) DME45J8 MT DTT DME45J8 MA Inhibitor DME45J8 RN Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, IX, and XII with N-hydroxy... Bioorg Med Chem Lett. 2005 May 2;15(9):2353-8. DME45J8 RU https://pubmed.ncbi.nlm.nih.gov/15837324 DME45J8 DI DME45J8 DME45J8 DN N-(pentafluorophenyl)sulfamide DME45J8 MI TTSYM0R DME45J8 MN Carbonic anhydrase XII (CA-XII) DME45J8 MT DTT DME45J8 MA Inhibitor DME45J8 RN Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, IX, and XII with N-hydroxy... Bioorg Med Chem Lett. 2005 May 2;15(9):2353-8. DME45J8 RU https://pubmed.ncbi.nlm.nih.gov/15837324 DMJO3B1 DI DMJO3B1 DMJO3B1 DN N'-(phenylsulfonyl)benzofuran-2-carbohydrazide DMJO3B1 MI TTF9OQ6 DMJO3B1 MN Branched-chain-amino-acid transaminase 2 (BCAT2) DMJO3B1 MT DTT DMJO3B1 MA Inhibitor DMJO3B1 RN The design and synthesis of human branched-chain amino acid aminotransferase inhibitors for treatment of neurodegenerative diseases. Bioorg Med Chem Lett. 2006 May 1;16(9):2337-40. DMJO3B1 RU https://pubmed.ncbi.nlm.nih.gov/16143519 DMQETUY DI DMQETUY DMQETUY DN N'-(phenylsulfonyl)quinoline-6-carbohydrazide DMQETUY MI TTF9OQ6 DMQETUY MN Branched-chain-amino-acid transaminase 2 (BCAT2) DMQETUY MT DTT DMQETUY MA Inhibitor DMQETUY RN The design and synthesis of human branched-chain amino acid aminotransferase inhibitors for treatment of neurodegenerative diseases. Bioorg Med Chem Lett. 2006 May 1;16(9):2337-40. DMQETUY RU https://pubmed.ncbi.nlm.nih.gov/16143519 DMGHQJ8 DI DMGHQJ8 DMGHQJ8 DN N-(phosphonacetyl)-L-aspartate DMGHQJ8 MI TT2YT1K DMGHQJ8 MN Aspartate carbamoyltransferase (CAD) DMGHQJ8 MT DTT DMGHQJ8 MA Inhibitor DMGHQJ8 RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMGHQJ8 RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMGHQJ8 DI DMGHQJ8 DMGHQJ8 DN N-(phosphonacetyl)-L-aspartate DMGHQJ8 MI TTANPDJ DMGHQJ8 MN Carbonic anhydrase II (CA-II) DMGHQJ8 MT DTT DMGHQJ8 MA Inhibitor DMGHQJ8 RN Carbonic anhydrase inhibitors. Interaction of isozymes I, II, IV, V, and IX with organic phosphates and phosphonates. Bioorg Med Chem Lett. 2005 Mar 15;15(6):1683-6. DMGHQJ8 RU https://pubmed.ncbi.nlm.nih.gov/15745821 DMGHQJ8 DI DMGHQJ8 DMGHQJ8 DN N-(phosphonacetyl)-L-aspartate DMGHQJ8 MI TTZHA0O DMGHQJ8 MN Carbonic anhydrase IV (CA-IV) DMGHQJ8 MT DTT DMGHQJ8 MA Inhibitor DMGHQJ8 RN Carbonic anhydrase inhibitors. Interaction of isozymes I, II, IV, V, and IX with organic phosphates and phosphonates. Bioorg Med Chem Lett. 2005 Mar 15;15(6):1683-6. DMGHQJ8 RU https://pubmed.ncbi.nlm.nih.gov/15745821 DMGHQJ8 DI DMGHQJ8 DMGHQJ8 DN N-(phosphonacetyl)-L-aspartate DMGHQJ8 MI TTDRBPW DMGHQJ8 MN Pseudomonas Aspartate carbamoyltransferase (Pseudo pyrB) DMGHQJ8 MT DTT DMGHQJ8 MA Inhibitor DMGHQJ8 RN Mechanism of resistance of variants of the Lewis lung carcinoma to N-(phosphonacetyl)-L-aspartic acid. Cancer Res. 1981 Mar;41(3):894-904. DMGHQJ8 RU https://pubmed.ncbi.nlm.nih.gov/7459875 DM9QIH4 DI DM9QIH4 DM9QIH4 DN N-(piperidin-4-yl)-N-propyl-2-naphthamide DM9QIH4 MI TT3ROYC DM9QIH4 MN Serotonin transporter (SERT) DM9QIH4 MT DTT DM9QIH4 MA Inhibitor DM9QIH4 RN Bioorg Med Chem Lett. 2009 Oct 15;19(20):5893-7. Epub 2009 Aug 21.Design and optimisation of selective serotonin re-uptake inhibitors with high synthetic accessibility: part 2. DM9QIH4 RU https://pubmed.ncbi.nlm.nih.gov/19740658 DM9QIH4 DI DM9QIH4 DM9QIH4 DN N-(piperidin-4-yl)-N-propyl-2-naphthamide DM9QIH4 MI TTQ6VDM DM9QIH4 MN Voltage-gated potassium channel Kv11.1 (KCNH2) DM9QIH4 MT DTT DM9QIH4 MA Inhibitor DM9QIH4 RN Bioorg Med Chem Lett. 2009 Oct 15;19(20):5893-7. Epub 2009 Aug 21.Design and optimisation of selective serotonin re-uptake inhibitors with high synthetic accessibility: part 2. DM9QIH4 RU https://pubmed.ncbi.nlm.nih.gov/19740658 DMULBO9 DI DMULBO9 DMULBO9 DN N-(p-methylbenzyl)-5-nitroindol-3-ylglyoxylamide DMULBO9 MI TT1MPAY DMULBO9 MN GABA(A) receptor alpha-1 (GABRA1) DMULBO9 MT DTT DMULBO9 MA Inhibitor DMULBO9 RN Novel N-substituted indol-3-ylglyoxylamides probing the LDi and L1/L2 lipophilic regions of the benzodiazepine receptor site in search for subtype-... J Med Chem. 2007 Apr 5;50(7):1627-34. DMULBO9 RU https://pubmed.ncbi.nlm.nih.gov/17335185 DMULBO9 DI DMULBO9 DMULBO9 DN N-(p-methylbenzyl)-5-nitroindol-3-ylglyoxylamide DMULBO9 MI TTZA1NY DMULBO9 MN GABA(A) receptor beta-2 (GABRB2) DMULBO9 MT DTT DMULBO9 MA Inhibitor DMULBO9 RN Novel N-substituted indol-3-ylglyoxylamides probing the LDi and L1/L2 lipophilic regions of the benzodiazepine receptor site in search for subtype-... J Med Chem. 2007 Apr 5;50(7):1627-34. DMULBO9 RU https://pubmed.ncbi.nlm.nih.gov/17335185 DMULBO9 DI DMULBO9 DMULBO9 DN N-(p-methylbenzyl)-5-nitroindol-3-ylglyoxylamide DMULBO9 MI TT06RH5 DMULBO9 MN GABA(A) receptor gamma-2 (GABRG2) DMULBO9 MT DTT DMULBO9 MA Inhibitor DMULBO9 RN Novel N-substituted indol-3-ylglyoxylamides probing the LDi and L1/L2 lipophilic regions of the benzodiazepine receptor site in search for subtype-... J Med Chem. 2007 Apr 5;50(7):1627-34. DMULBO9 RU https://pubmed.ncbi.nlm.nih.gov/17335185 DMTJ5WL DI DMTJ5WL DMTJ5WL DN N-(propargyl),N-(pyrrol-2-ylmethyl)amine DMTJ5WL MI TT3WG5C DMTJ5WL MN Monoamine oxidase type A (MAO-A) DMTJ5WL MT DTT DMTJ5WL MA Inhibitor DMTJ5WL RN New pyrrole inhibitors of monoamine oxidase: synthesis, biological evaluation, and structural determinants of MAO-A and MAO-B selectivity. J Med Chem. 2007 Mar 8;50(5):922-31. DMTJ5WL RU https://pubmed.ncbi.nlm.nih.gov/17256833 DMTJ5WL DI DMTJ5WL DMTJ5WL DN N-(propargyl),N-(pyrrol-2-ylmethyl)amine DMTJ5WL MI TTGP7BY DMTJ5WL MN Monoamine oxidase type B (MAO-B) DMTJ5WL MT DTT DMTJ5WL MA Inhibitor DMTJ5WL RN New pyrrole inhibitors of monoamine oxidase: synthesis, biological evaluation, and structural determinants of MAO-A and MAO-B selectivity. J Med Chem. 2007 Mar 8;50(5):922-31. DMTJ5WL RU https://pubmed.ncbi.nlm.nih.gov/17256833 DMXI4V8 DI DMXI4V8 DMXI4V8 DN N-(Propylamide-acetophenone)-1-deoxynojirimycin DMXI4V8 MI TT1B5PU DMXI4V8 MN Glucosylceramidase (GBA) DMXI4V8 MT DTT DMXI4V8 MA Inhibitor DMXI4V8 RN Nanomolar affinity, iminosugar-based chemical probes for specific labeling of lysosomal glucocerebrosidase. Bioorg Med Chem. 2010 Jan 1;18(1):267-73. DMXI4V8 RU https://pubmed.ncbi.nlm.nih.gov/19931460 DMCZHBI DI DMCZHBI DMCZHBI DN N-(Propylamide-benzophenone)-1-deoxynojirimycin DMCZHBI MI TT1B5PU DMCZHBI MN Glucosylceramidase (GBA) DMCZHBI MT DTT DMCZHBI MA Inhibitor DMCZHBI RN Nanomolar affinity, iminosugar-based chemical probes for specific labeling of lysosomal glucocerebrosidase. Bioorg Med Chem. 2010 Jan 1;18(1):267-73. DMCZHBI RU https://pubmed.ncbi.nlm.nih.gov/19931460 DMTHJL4 DI DMTHJL4 DMTHJL4 DN N-(pyridin-3-yl)indoline-1-carboxamide DMTHJL4 MI TTWJBZ5 DMTHJL4 MN 5-HT 2C receptor (HTR2C) DMTHJL4 MT DTT DMTHJL4 MA Inhibitor DMTHJL4 RN Synthesis and structure-affinity relationships of novel small molecule natural product derivatives capable of discriminating between serotonin 5-HT1A, 5-HT2A, 5-HT2C receptor subtypes. Bioorg Med Chem. 2010 Jul 1;18(13):4783-92. DMTHJL4 RU https://pubmed.ncbi.nlm.nih.gov/20570529 DMBJKH1 DI DMBJKH1 DMBJKH1 DN N-(pyridin-3-ylmethyl) estradiol-16-carboxamide DMBJKH1 MI TTIWB6L DMBJKH1 MN Estradiol 17 beta-dehydrogenase 1 (17-beta-HSD1) DMBJKH1 MT DTT DMBJKH1 MA Inhibitor DMBJKH1 RN Modification of estrone at the 6, 16, and 17 positions: novel potent inhibitors of 17beta-hydroxysteroid dehydrogenase type 1. J Med Chem. 2006 Feb 23;49(4):1325-45. DMBJKH1 RU https://pubmed.ncbi.nlm.nih.gov/16480268 DMIN60B DI DMIN60B DMIN60B DN N-(pyridin-3-ylmethyl)aniline DMIN60B MI TTXZEAJ DMIN60B MN Leukotriene A-4 hydrolase (LTA4H) DMIN60B MT DTT DMIN60B MA Inhibitor DMIN60B RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DMIN60B RU https://pubmed.ncbi.nlm.nih.gov/10592235 DMYFAQV DI DMYFAQV DMYFAQV DN N-(pyridin-4-ylmethyl) estradiol-16-carboxamide DMYFAQV MI TTIWB6L DMYFAQV MN Estradiol 17 beta-dehydrogenase 1 (17-beta-HSD1) DMYFAQV MT DTT DMYFAQV MA Inhibitor DMYFAQV RN Modification of estrone at the 6, 16, and 17 positions: novel potent inhibitors of 17beta-hydroxysteroid dehydrogenase type 1. J Med Chem. 2006 Feb 23;49(4):1325-45. DMYFAQV RU https://pubmed.ncbi.nlm.nih.gov/16480268 DMYEQXH DI DMYEQXH DMYEQXH DN N-(quinolin-3-yl)-6-(sulfamoylamino)hexanamide DMYEQXH MI TT5ZKDI DMYEQXH MN Histone deacetylase 6 (HDAC6) DMYEQXH MT DTT DMYEQXH MA Inhibitor DMYEQXH RN Sulfamides as novel histone deacetylase inhibitors. Bioorg Med Chem Lett. 2009 Jan 15;19(2):336-40. DMYEQXH RU https://pubmed.ncbi.nlm.nih.gov/19084395 DMFC3XI DI DMFC3XI DMFC3XI DN N-(quinolin-6-yl)-6-(sulfamoylamino)hexanamide DMFC3XI MI TT5ZKDI DMFC3XI MN Histone deacetylase 6 (HDAC6) DMFC3XI MT DTT DMFC3XI MA Inhibitor DMFC3XI RN Sulfamides as novel histone deacetylase inhibitors. Bioorg Med Chem Lett. 2009 Jan 15;19(2):336-40. DMFC3XI RU https://pubmed.ncbi.nlm.nih.gov/19084395 DML8EVA DI DML8EVA DML8EVA DN N-(quinolin-8-yl)-6-(sulfamoylamino)hexanamide DML8EVA MI TT5ZKDI DML8EVA MN Histone deacetylase 6 (HDAC6) DML8EVA MT DTT DML8EVA MA Inhibitor DML8EVA RN Sulfamides as novel histone deacetylase inhibitors. Bioorg Med Chem Lett. 2009 Jan 15;19(2):336-40. DML8EVA RU https://pubmed.ncbi.nlm.nih.gov/19084395 DM7O1F3 DI DM7O1F3 DM7O1F3 DN N-(quinolin-8-yl)thiophene-2-sulfonamide DM7O1F3 MI TTSXVID DM7O1F3 MN Nuclear factor NF-kappa-B (NFKB) DM7O1F3 MT DTT DM7O1F3 MA Inhibitor DM7O1F3 RN Identification of N-(quinolin-8-yl)benzenesulfonamides as agents capable of down-regulating NFkappaB activity within two separate high-throughput s... Bioorg Med Chem Lett. 2008 Jan 1;18(1):329-35. DM7O1F3 RU https://pubmed.ncbi.nlm.nih.gov/18024113 DM2SNXB DI DM2SNXB DM2SNXB DN N-(R-Carboxy-Ethyl)-Alpha-(S)-(2-Phenylethyl) DM2SNXB MI TTXMNHO DM2SNXB MN Plasmodium Plasmepsin 2 (Malaria PLA2) DM2SNXB MT DTT DM2SNXB MA Inhibitor DM2SNXB RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DM2SNXB RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMWJDYZ DI DMWJDYZ DMWJDYZ DN N-(Sulfanylacetyl)Tyrosylprolylmethioninamide DMWJDYZ MI TTIQSC1 DMWJDYZ MN Bacterial Lethal factor (Bact lef) DMWJDYZ MT DTT DMWJDYZ MA Inhibitor DMWJDYZ RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMWJDYZ RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMJ0S5C DI DMJ0S5C DMJ0S5C DN N-(tert-butoxycarbonyl)-isoleucyl-glycine-nitrile DMJ0S5C MI TTDZN01 DMJ0S5C MN Cathepsin K (CTSK) DMJ0S5C MT DTT DMJ0S5C MA Inhibitor DMJ0S5C RN Interaction of papain-like cysteine proteases with dipeptide-derived nitriles. J Med Chem. 2005 Dec 1;48(24):7688-707. DMJ0S5C RU https://pubmed.ncbi.nlm.nih.gov/16302809 DMJ0S5C DI DMJ0S5C DMJ0S5C DN N-(tert-butoxycarbonyl)-isoleucyl-glycine-nitrile DMJ0S5C MI TT36ETB DMJ0S5C MN Cathepsin L (CTSL) DMJ0S5C MT DTT DMJ0S5C MA Inhibitor DMJ0S5C RN Interaction of papain-like cysteine proteases with dipeptide-derived nitriles. J Med Chem. 2005 Dec 1;48(24):7688-707. DMJ0S5C RU https://pubmed.ncbi.nlm.nih.gov/16302809 DMJ0S5C DI DMJ0S5C DMJ0S5C DN N-(tert-butoxycarbonyl)-isoleucyl-glycine-nitrile DMJ0S5C MI TTUMQVO DMJ0S5C MN Cathepsin S (CTSS) DMJ0S5C MT DTT DMJ0S5C MA Inhibitor DMJ0S5C RN Interaction of papain-like cysteine proteases with dipeptide-derived nitriles. J Med Chem. 2005 Dec 1;48(24):7688-707. DMJ0S5C RU https://pubmed.ncbi.nlm.nih.gov/16302809 DMXYQWG DI DMXYQWG DMXYQWG DN N-(tert-butoxycarbonyl)-leucyl-glycine-nitrile DMXYQWG MI TTDZN01 DMXYQWG MN Cathepsin K (CTSK) DMXYQWG MT DTT DMXYQWG MA Inhibitor DMXYQWG RN Interaction of papain-like cysteine proteases with dipeptide-derived nitriles. J Med Chem. 2005 Dec 1;48(24):7688-707. DMXYQWG RU https://pubmed.ncbi.nlm.nih.gov/16302809 DMXYQWG DI DMXYQWG DMXYQWG DN N-(tert-butoxycarbonyl)-leucyl-glycine-nitrile DMXYQWG MI TT36ETB DMXYQWG MN Cathepsin L (CTSL) DMXYQWG MT DTT DMXYQWG MA Inhibitor DMXYQWG RN Interaction of papain-like cysteine proteases with dipeptide-derived nitriles. J Med Chem. 2005 Dec 1;48(24):7688-707. DMXYQWG RU https://pubmed.ncbi.nlm.nih.gov/16302809 DMXYQWG DI DMXYQWG DMXYQWG DN N-(tert-butoxycarbonyl)-leucyl-glycine-nitrile DMXYQWG MI TTUMQVO DMXYQWG MN Cathepsin S (CTSS) DMXYQWG MT DTT DMXYQWG MA Inhibitor DMXYQWG RN Interaction of papain-like cysteine proteases with dipeptide-derived nitriles. J Med Chem. 2005 Dec 1;48(24):7688-707. DMXYQWG RU https://pubmed.ncbi.nlm.nih.gov/16302809 DM3I0WZ DI DM3I0WZ DM3I0WZ DN N-(tert-butoxycarbonyl)-methionyl-glycine-nitrile DM3I0WZ MI TTDZN01 DM3I0WZ MN Cathepsin K (CTSK) DM3I0WZ MT DTT DM3I0WZ MA Inhibitor DM3I0WZ RN Interaction of papain-like cysteine proteases with dipeptide-derived nitriles. J Med Chem. 2005 Dec 1;48(24):7688-707. DM3I0WZ RU https://pubmed.ncbi.nlm.nih.gov/16302809 DM3I0WZ DI DM3I0WZ DM3I0WZ DN N-(tert-butoxycarbonyl)-methionyl-glycine-nitrile DM3I0WZ MI TT36ETB DM3I0WZ MN Cathepsin L (CTSL) DM3I0WZ MT DTT DM3I0WZ MA Inhibitor DM3I0WZ RN Interaction of papain-like cysteine proteases with dipeptide-derived nitriles. J Med Chem. 2005 Dec 1;48(24):7688-707. DM3I0WZ RU https://pubmed.ncbi.nlm.nih.gov/16302809 DM3I0WZ DI DM3I0WZ DM3I0WZ DN N-(tert-butoxycarbonyl)-methionyl-glycine-nitrile DM3I0WZ MI TTUMQVO DM3I0WZ MN Cathepsin S (CTSS) DM3I0WZ MT DTT DM3I0WZ MA Inhibitor DM3I0WZ RN Interaction of papain-like cysteine proteases with dipeptide-derived nitriles. J Med Chem. 2005 Dec 1;48(24):7688-707. DM3I0WZ RU https://pubmed.ncbi.nlm.nih.gov/16302809 DMGF4XC DI DMGF4XC DMGF4XC DN N-(tert-butoxycarbonyl)-norleucyl-glycine-nitrile DMGF4XC MI TTDZN01 DMGF4XC MN Cathepsin K (CTSK) DMGF4XC MT DTT DMGF4XC MA Inhibitor DMGF4XC RN Interaction of papain-like cysteine proteases with dipeptide-derived nitriles. J Med Chem. 2005 Dec 1;48(24):7688-707. DMGF4XC RU https://pubmed.ncbi.nlm.nih.gov/16302809 DMGF4XC DI DMGF4XC DMGF4XC DN N-(tert-butoxycarbonyl)-norleucyl-glycine-nitrile DMGF4XC MI TT36ETB DMGF4XC MN Cathepsin L (CTSL) DMGF4XC MT DTT DMGF4XC MA Inhibitor DMGF4XC RN Interaction of papain-like cysteine proteases with dipeptide-derived nitriles. J Med Chem. 2005 Dec 1;48(24):7688-707. DMGF4XC RU https://pubmed.ncbi.nlm.nih.gov/16302809 DMGF4XC DI DMGF4XC DMGF4XC DN N-(tert-butoxycarbonyl)-norleucyl-glycine-nitrile DMGF4XC MI TTUMQVO DMGF4XC MN Cathepsin S (CTSS) DMGF4XC MT DTT DMGF4XC MA Inhibitor DMGF4XC RN Interaction of papain-like cysteine proteases with dipeptide-derived nitriles. J Med Chem. 2005 Dec 1;48(24):7688-707. DMGF4XC RU https://pubmed.ncbi.nlm.nih.gov/16302809 DMOP5N7 DI DMOP5N7 DMOP5N7 DN N-(tert-butoxycarbonyl)-norvalyl-glycine-nitrile DMOP5N7 MI TTDZN01 DMOP5N7 MN Cathepsin K (CTSK) DMOP5N7 MT DTT DMOP5N7 MA Inhibitor DMOP5N7 RN Interaction of papain-like cysteine proteases with dipeptide-derived nitriles. J Med Chem. 2005 Dec 1;48(24):7688-707. DMOP5N7 RU https://pubmed.ncbi.nlm.nih.gov/16302809 DMOP5N7 DI DMOP5N7 DMOP5N7 DN N-(tert-butoxycarbonyl)-norvalyl-glycine-nitrile DMOP5N7 MI TTUMQVO DMOP5N7 MN Cathepsin S (CTSS) DMOP5N7 MT DTT DMOP5N7 MA Inhibitor DMOP5N7 RN Interaction of papain-like cysteine proteases with dipeptide-derived nitriles. J Med Chem. 2005 Dec 1;48(24):7688-707. DMOP5N7 RU https://pubmed.ncbi.nlm.nih.gov/16302809 DMP9JVT DI DMP9JVT DMP9JVT DN N-(tert-butoxycarbonyl)-tyrosyl-glycine-nitrile DMP9JVT MI TT36ETB DMP9JVT MN Cathepsin L (CTSL) DMP9JVT MT DTT DMP9JVT MA Inhibitor DMP9JVT RN Interaction of papain-like cysteine proteases with dipeptide-derived nitriles. J Med Chem. 2005 Dec 1;48(24):7688-707. DMP9JVT RU https://pubmed.ncbi.nlm.nih.gov/16302809 DMP9JVT DI DMP9JVT DMP9JVT DN N-(tert-butoxycarbonyl)-tyrosyl-glycine-nitrile DMP9JVT MI TTUMQVO DMP9JVT MN Cathepsin S (CTSS) DMP9JVT MT DTT DMP9JVT MA Inhibitor DMP9JVT RN Interaction of papain-like cysteine proteases with dipeptide-derived nitriles. J Med Chem. 2005 Dec 1;48(24):7688-707. DMP9JVT RU https://pubmed.ncbi.nlm.nih.gov/16302809 DMUQBOP DI DMUQBOP DMUQBOP DN N-(tert-butoxycarbonyl)-valyl-glycine-nitrile DMUQBOP MI TTDZN01 DMUQBOP MN Cathepsin K (CTSK) DMUQBOP MT DTT DMUQBOP MA Inhibitor DMUQBOP RN Interaction of papain-like cysteine proteases with dipeptide-derived nitriles. J Med Chem. 2005 Dec 1;48(24):7688-707. DMUQBOP RU https://pubmed.ncbi.nlm.nih.gov/16302809 DMUQBOP DI DMUQBOP DMUQBOP DN N-(tert-butoxycarbonyl)-valyl-glycine-nitrile DMUQBOP MI TT36ETB DMUQBOP MN Cathepsin L (CTSL) DMUQBOP MT DTT DMUQBOP MA Inhibitor DMUQBOP RN Interaction of papain-like cysteine proteases with dipeptide-derived nitriles. J Med Chem. 2005 Dec 1;48(24):7688-707. DMUQBOP RU https://pubmed.ncbi.nlm.nih.gov/16302809 DMUQBOP DI DMUQBOP DMUQBOP DN N-(tert-butoxycarbonyl)-valyl-glycine-nitrile DMUQBOP MI TTUMQVO DMUQBOP MN Cathepsin S (CTSS) DMUQBOP MT DTT DMUQBOP MA Inhibitor DMUQBOP RN Interaction of papain-like cysteine proteases with dipeptide-derived nitriles. J Med Chem. 2005 Dec 1;48(24):7688-707. DMUQBOP RU https://pubmed.ncbi.nlm.nih.gov/16302809 DM1N7AG DI DM1N7AG DM1N7AG DN N-(thiazol-2-yl)benzamide DM1N7AG MI TTSJ6Q4 DM1N7AG MN LOX-5 messenger RNA (ALOX5 mRNA) DM1N7AG MT DTT DM1N7AG MA Inhibitor DM1N7AG RN Identification of natural-product-derived inhibitors of 5-lipoxygenase activity by ligand-based virtual screening. J Med Chem. 2007 May 31;50(11):2640-6. DM1N7AG RU https://pubmed.ncbi.nlm.nih.gov/17461565 DM8JQEO DI DM8JQEO DM8JQEO DN N*1*-(5-Methyl-2-nitro-phenyl)-butane-1,4-diamine DM8JQEO MI TTZUFI5 DM8JQEO MN Nitric-oxide synthase brain (NOS1) DM8JQEO MT DTT DM8JQEO MA Inhibitor DM8JQEO RN Nitroaromatic amino acids as inhibitors of neuronal nitric oxide synthase. J Med Chem. 1998 Jul 2;41(14):2636-42. DM8JQEO RU https://pubmed.ncbi.nlm.nih.gov/9651169 DME8KXT DI DME8KXT DME8KXT DN N*1*-(6-Nitro-quinolin-2-yl)-ethane-1,2-diamine DME8KXT MI TT3ROYC DME8KXT MN Serotonin transporter (SERT) DME8KXT MT DTT DME8KXT MA Inhibitor DME8KXT RN Syntheses and binding affinities of 6-nitroquipazine analogues for serotonin transporter. Part 1. Bioorg Med Chem Lett. 2000 Jul 17;10(14):1559-62. DME8KXT RU https://pubmed.ncbi.nlm.nih.gov/10915050 DM41TQB DI DM41TQB DM41TQB DN N*2*-Benzyl-N*6*-cyclohexyl-9H-purine-2,6-diamine DM41TQB MI TTJFY5U DM41TQB MN Adenosine A3 receptor (ADORA3) DM41TQB MT DTT DM41TQB MA Inhibitor DM41TQB RN Reversine and its 2-substituted adenine derivatives as potent and selective A3 adenosine receptor antagonists. J Med Chem. 2005 Jul 28;48(15):4910-8. DM41TQB RU https://pubmed.ncbi.nlm.nih.gov/16033270 DMFWN5U DI DMFWN5U DMFWN5U DN N*4*-(3-Bromo-phenyl)-quinazoline-4,6,7-triamine DMFWN5U MI TTGKNB4 DMFWN5U MN Epidermal growth factor receptor (EGFR) DMFWN5U MT DTT DMFWN5U MA Inhibitor DMFWN5U RN Tyrosine kinase inhibitors. 9. Synthesis and evaluation of fused tricyclic quinazoline analogues as ATP site inhibitors of the tyrosine kinase acti... J Med Chem. 1996 Feb 16;39(4):918-28. DMFWN5U RU https://pubmed.ncbi.nlm.nih.gov/8632415 DMUI8RC DI DMUI8RC DMUI8RC DN N*4*-(3-Bromo-phenyl)-quinazoline-4,6-diamine DMUI8RC MI TTGKNB4 DMUI8RC MN Epidermal growth factor receptor (EGFR) DMUI8RC MT DTT DMUI8RC MA Inhibitor DMUI8RC RN Synthesis of a prodrug designed to release multiple inhibitors of the epidermal growth factor receptor tyrosine kinase and an alkylating agent: a n... J Med Chem. 2003 Dec 4;46(25):5546-51. DMUI8RC RU https://pubmed.ncbi.nlm.nih.gov/14640561 DMO56XY DI DMO56XY DMO56XY DN N*4*-(3-Bromo-phenyl)-quinazoline-4,7-diamine DMO56XY MI TTGKNB4 DMO56XY MN Epidermal growth factor receptor (EGFR) DMO56XY MT DTT DMO56XY MA Inhibitor DMO56XY RN Tyrosine kinase inhibitors. 5. Synthesis and structure-activity relationships for 4-[(phenylmethyl)amino]- and 4-(phenylamino)quinazolines as poten... J Med Chem. 1995 Sep 1;38(18):3482-7. DMO56XY RU https://pubmed.ncbi.nlm.nih.gov/7658435 DMNGSQK DI DMNGSQK DMNGSQK DN N*4*-Benzyl-6-chloro-pyrimidine-2,4-diamine DMNGSQK MI TT2GPK3 DMNGSQK MN DNA topoisomerase (TOP) DMNGSQK MT DTT DMNGSQK MA Inhibitor DMNGSQK RN Inhibitors of Bacillus subtilis DNA polymerase III. Influence of modifications in the pyrimidine ring of anilino- and (benzylamino)pyrimidines. J Med Chem. 1986 May;29(5):676-81. DMNGSQK RU https://pubmed.ncbi.nlm.nih.gov/3084785 DMK674I DI DMK674I DMK674I DN N*4*-Benzyl-pyrido[4,3-d]pyrimidine-4,7-diamine DMK674I MI TTGKNB4 DMK674I MN Epidermal growth factor receptor (EGFR) DMK674I MT DTT DMK674I MA Inhibitor DMK674I RN Tyrosine kinase inhibitors. 10. Isomeric 4-[(3-bromophenyl)amino]pyrido[d]-pyrimidines are potent ATP binding site inhibitors of the tyrosine kinas... J Med Chem. 1996 Apr 26;39(9):1823-35. DMK674I RU https://pubmed.ncbi.nlm.nih.gov/8627606 DMRNGV0 DI DMRNGV0 DMRNGV0 DN N*6*-Benzyl-quinazoline-2,4,6-triamine DMRNGV0 MI TT9SL3Q DMRNGV0 MN Polypeptide deformylase (PDF) DMRNGV0 MT DTT DMRNGV0 MA Inhibitor DMRNGV0 RN CoMFA and CoMSIA analyses of Pneumocystis carinii dihydrofolate reductase, Toxoplasma gondii dihydrofolate reductase, and rat liver dihydrofolate r... J Med Chem. 2005 Mar 10;48(5):1448-69. DMRNGV0 RU https://pubmed.ncbi.nlm.nih.gov/15743188 DM1K2A4 DI DM1K2A4 DM1K2A4 DN N*6*-Cyclohexyl-N*2*-ethyl-9H-purine-2,6-diamine DM1K2A4 MI TTK25J1 DM1K2A4 MN Adenosine A1 receptor (ADORA1) DM1K2A4 MT DTT DM1K2A4 MA Inhibitor DM1K2A4 RN Reversine and its 2-substituted adenine derivatives as potent and selective A3 adenosine receptor antagonists. J Med Chem. 2005 Jul 28;48(15):4910-8. DM1K2A4 RU https://pubmed.ncbi.nlm.nih.gov/16033270 DM1K2A4 DI DM1K2A4 DM1K2A4 DN N*6*-Cyclohexyl-N*2*-ethyl-9H-purine-2,6-diamine DM1K2A4 MI TTJFY5U DM1K2A4 MN Adenosine A3 receptor (ADORA3) DM1K2A4 MT DTT DM1K2A4 MA Inhibitor DM1K2A4 RN Reversine and its 2-substituted adenine derivatives as potent and selective A3 adenosine receptor antagonists. J Med Chem. 2005 Jul 28;48(15):4910-8. DM1K2A4 RU https://pubmed.ncbi.nlm.nih.gov/16033270 DM3C8PJ DI DM3C8PJ DM3C8PJ DN N*6*-Cyclohexyl-N*2*-phenyl-9H-purine-2,6-diamine DM3C8PJ MI TTK25J1 DM3C8PJ MN Adenosine A1 receptor (ADORA1) DM3C8PJ MT DTT DM3C8PJ MA Inhibitor DM3C8PJ RN Reversine and its 2-substituted adenine derivatives as potent and selective A3 adenosine receptor antagonists. J Med Chem. 2005 Jul 28;48(15):4910-8. DM3C8PJ RU https://pubmed.ncbi.nlm.nih.gov/16033270 DM3C8PJ DI DM3C8PJ DM3C8PJ DN N*6*-Cyclohexyl-N*2*-phenyl-9H-purine-2,6-diamine DM3C8PJ MI TTM2AOE DM3C8PJ MN Adenosine A2a receptor (ADORA2A) DM3C8PJ MT DTT DM3C8PJ MA Inhibitor DM3C8PJ RN Reversine and its 2-substituted adenine derivatives as potent and selective A3 adenosine receptor antagonists. J Med Chem. 2005 Jul 28;48(15):4910-8. DM3C8PJ RU https://pubmed.ncbi.nlm.nih.gov/16033270 DM3C8PJ DI DM3C8PJ DM3C8PJ DN N*6*-Cyclohexyl-N*2*-phenyl-9H-purine-2,6-diamine DM3C8PJ MI TTJFY5U DM3C8PJ MN Adenosine A3 receptor (ADORA3) DM3C8PJ MT DTT DM3C8PJ MA Inhibitor DM3C8PJ RN Reversine and its 2-substituted adenine derivatives as potent and selective A3 adenosine receptor antagonists. J Med Chem. 2005 Jul 28;48(15):4910-8. DM3C8PJ RU https://pubmed.ncbi.nlm.nih.gov/16033270 DMCOPR3 DI DMCOPR3 DMCOPR3 DN N*6*-Cyclooctyl-N*2*-phenyl-9H-purine-2,6-diamine DMCOPR3 MI TTK25J1 DMCOPR3 MN Adenosine A1 receptor (ADORA1) DMCOPR3 MT DTT DMCOPR3 MA Inhibitor DMCOPR3 RN Reversine and its 2-substituted adenine derivatives as potent and selective A3 adenosine receptor antagonists. J Med Chem. 2005 Jul 28;48(15):4910-8. DMCOPR3 RU https://pubmed.ncbi.nlm.nih.gov/16033270 DMCOPR3 DI DMCOPR3 DMCOPR3 DN N*6*-Cyclooctyl-N*2*-phenyl-9H-purine-2,6-diamine DMCOPR3 MI TTJFY5U DMCOPR3 MN Adenosine A3 receptor (ADORA3) DMCOPR3 MT DTT DMCOPR3 MA Inhibitor DMCOPR3 RN Reversine and its 2-substituted adenine derivatives as potent and selective A3 adenosine receptor antagonists. J Med Chem. 2005 Jul 28;48(15):4910-8. DMCOPR3 RU https://pubmed.ncbi.nlm.nih.gov/16033270 DMWKRJX DI DMWKRJX DMWKRJX DN N',2-diphenylquinoline-4-carbohydrazide DMWKRJX MI TTBPGLU DMWKRJX MN Neuromedin-K receptor (TACR3) DMWKRJX MT DTT DMWKRJX MA Antagonist DMWKRJX RN N',2-diphenylquinoline-4-carbohydrazide based NK3 receptor antagonists. Bioorg Med Chem Lett. 2006 Nov 15;16(22):5748-51. DMWKRJX RU https://pubmed.ncbi.nlm.nih.gov/16950620 DMNJA3C DI DMNJA3C DMNJA3C DN N',2-diphenylquinoline-4-carbohydrazide 8m DMNJA3C MI TTBPGLU DMNJA3C MN Neuromedin-K receptor (TACR3) DMNJA3C MT DTT DMNJA3C MA Antagonist DMNJA3C RN N',2-diphenylquinoline-4-carbohydrazide based NK3 receptor antagonists II. Bioorg Med Chem Lett. 2006 Nov 15;16(22):5752-6. DMNJA3C RU https://pubmed.ncbi.nlm.nih.gov/16950617 DMOG37L DI DMOG37L DMOG37L DN N,4-dibenzhydrylpiperazine-1-carboxamide DMOG37L MI TTFK1JQ DMOG37L MN Voltage-gated calcium channel alpha-2/delta-1 (CACNA2D1) DMOG37L MT DTT DMOG37L MA Inhibitor DMOG37L RN Scaffold-based design and synthesis of potent N-type calcium channel blockers. Bioorg Med Chem Lett. 2009 Nov 15;19(22):6467-72. DMOG37L RU https://pubmed.ncbi.nlm.nih.gov/19815411 DMMTQ3N DI DMMTQ3N DMMTQ3N DN N,4-dimethyl-3,4-dihydroquinazolin-2-amine DMMTQ3N MI TTRUFDT DMMTQ3N MN 5-HT 5A receptor (HTR5A) DMMTQ3N MT DTT DMMTQ3N MA Inhibitor DMMTQ3N RN Cyclic guanidines as dual 5-HT5A/5-HT7 receptor ligands: optimising brain penetration. Bioorg Med Chem Lett. 2008 Jan 1;18(1):262-6. DMMTQ3N RU https://pubmed.ncbi.nlm.nih.gov/18023344 DM8G0WX DI DM8G0WX DM8G0WX DN N,8-dihydroxy-8-(naphthalen-2-yl)octanamide DM8G0WX MI TT6R7JZ DM8G0WX MN Histone deacetylase 1 (HDAC1) DM8G0WX MT DTT DM8G0WX MA Inhibitor DM8G0WX RN 3D-QSAR studies of HDACs inhibitors using pharmacophore-based alignment. Eur J Med Chem. 2009 Jul;44(7):2868-76. DM8G0WX RU https://pubmed.ncbi.nlm.nih.gov/19136179 DMZXF36 DI DMZXF36 DMZXF36 DN N,8-diphenyl-9H-purin-6-amine DMZXF36 MI TTRSMW9 DMZXF36 MN Glycogen synthase kinase-3 beta (GSK-3B) DMZXF36 MT DTT DMZXF36 MA Inhibitor DMZXF36 RN Novel 8-arylated purines as inhibitors of glycogen synthase kinase. Eur J Med Chem. 2010 Aug;45(8):3389-93. DMZXF36 RU https://pubmed.ncbi.nlm.nih.gov/20472330 DMIX0CT DI DMIX0CT DMIX0CT DN N,N'-(1',10'-decylene)-bis-(-)-nor-MEP DMIX0CT MI TT1RS9F DMIX0CT MN Acetylcholinesterase (AChE) DMIX0CT MT DTT DMIX0CT MA Inhibitor DMIX0CT RN Bis-(-)-nor-meptazinols as novel nanomolar cholinesterase inhibitors with high inhibitory potency on amyloid-beta aggregation. J Med Chem. 2008 Apr 10;51(7):2027-36. DMIX0CT RU https://pubmed.ncbi.nlm.nih.gov/18333606 DMIX0CT DI DMIX0CT DMIX0CT DN N,N'-(1',10'-decylene)-bis-(-)-nor-MEP DMIX0CT MI TTEB0GD DMIX0CT MN Cholinesterase (BCHE) DMIX0CT MT DTT DMIX0CT MA Inhibitor DMIX0CT RN Bis-(-)-nor-meptazinols as novel nanomolar cholinesterase inhibitors with high inhibitory potency on amyloid-beta aggregation. J Med Chem. 2008 Apr 10;51(7):2027-36. DMIX0CT RU https://pubmed.ncbi.nlm.nih.gov/18333606 DM5NVIO DI DM5NVIO DM5NVIO DN N,N'-(1',11'-undecydene)-bis-(-)-nor-MEP DM5NVIO MI TT1RS9F DM5NVIO MN Acetylcholinesterase (AChE) DM5NVIO MT DTT DM5NVIO MA Inhibitor DM5NVIO RN Bis-(-)-nor-meptazinols as novel nanomolar cholinesterase inhibitors with high inhibitory potency on amyloid-beta aggregation. J Med Chem. 2008 Apr 10;51(7):2027-36. DM5NVIO RU https://pubmed.ncbi.nlm.nih.gov/18333606 DM5NVIO DI DM5NVIO DM5NVIO DN N,N'-(1',11'-undecydene)-bis-(-)-nor-MEP DM5NVIO MI TTEB0GD DM5NVIO MN Cholinesterase (BCHE) DM5NVIO MT DTT DM5NVIO MA Inhibitor DM5NVIO RN Bis-(-)-nor-meptazinols as novel nanomolar cholinesterase inhibitors with high inhibitory potency on amyloid-beta aggregation. J Med Chem. 2008 Apr 10;51(7):2027-36. DM5NVIO RU https://pubmed.ncbi.nlm.nih.gov/18333606 DMWI06H DI DMWI06H DMWI06H DN N,N'-(1',12'-dodecydene)-bis-(-)-nor-MEP DMWI06H MI TT1RS9F DMWI06H MN Acetylcholinesterase (AChE) DMWI06H MT DTT DMWI06H MA Inhibitor DMWI06H RN Bis-(-)-nor-meptazinols as novel nanomolar cholinesterase inhibitors with high inhibitory potency on amyloid-beta aggregation. J Med Chem. 2008 Apr 10;51(7):2027-36. DMWI06H RU https://pubmed.ncbi.nlm.nih.gov/18333606 DMWI06H DI DMWI06H DMWI06H DN N,N'-(1',12'-dodecydene)-bis-(-)-nor-MEP DMWI06H MI TTEB0GD DMWI06H MN Cholinesterase (BCHE) DMWI06H MT DTT DMWI06H MA Inhibitor DMWI06H RN Bis-(-)-nor-meptazinols as novel nanomolar cholinesterase inhibitors with high inhibitory potency on amyloid-beta aggregation. J Med Chem. 2008 Apr 10;51(7):2027-36. DMWI06H RU https://pubmed.ncbi.nlm.nih.gov/18333606 DM1LKEP DI DM1LKEP DM1LKEP DN N,N'-(1',2'-ethylene)-bis-(-)-nor-MEP DM1LKEP MI TTEB0GD DM1LKEP MN Cholinesterase (BCHE) DM1LKEP MT DTT DM1LKEP MA Inhibitor DM1LKEP RN Bis-(-)-nor-meptazinols as novel nanomolar cholinesterase inhibitors with high inhibitory potency on amyloid-beta aggregation. J Med Chem. 2008 Apr 10;51(7):2027-36. DM1LKEP RU https://pubmed.ncbi.nlm.nih.gov/18333606 DM4G6BT DI DM4G6BT DM4G6BT DN N,N'-(1',3'-propylene)-bis-(-)-nor-MEP DM4G6BT MI TTEB0GD DM4G6BT MN Cholinesterase (BCHE) DM4G6BT MT DTT DM4G6BT MA Inhibitor DM4G6BT RN Bis-(-)-nor-meptazinols as novel nanomolar cholinesterase inhibitors with high inhibitory potency on amyloid-beta aggregation. J Med Chem. 2008 Apr 10;51(7):2027-36. DM4G6BT RU https://pubmed.ncbi.nlm.nih.gov/18333606 DMZHBTA DI DMZHBTA DMZHBTA DN N,N'-(1',4'-butylene)-bis-(-)-nor-MEP DMZHBTA MI TTEB0GD DMZHBTA MN Cholinesterase (BCHE) DMZHBTA MT DTT DMZHBTA MA Inhibitor DMZHBTA RN Bis-(-)-nor-meptazinols as novel nanomolar cholinesterase inhibitors with high inhibitory potency on amyloid-beta aggregation. J Med Chem. 2008 Apr 10;51(7):2027-36. DMZHBTA RU https://pubmed.ncbi.nlm.nih.gov/18333606 DMBPC0K DI DMBPC0K DMBPC0K DN N,N'-(1',5'-pentylene)-bis-(-)-nor-MEP DMBPC0K MI TT1RS9F DMBPC0K MN Acetylcholinesterase (AChE) DMBPC0K MT DTT DMBPC0K MA Inhibitor DMBPC0K RN Bis-(-)-nor-meptazinols as novel nanomolar cholinesterase inhibitors with high inhibitory potency on amyloid-beta aggregation. J Med Chem. 2008 Apr 10;51(7):2027-36. DMBPC0K RU https://pubmed.ncbi.nlm.nih.gov/18333606 DMBPC0K DI DMBPC0K DMBPC0K DN N,N'-(1',5'-pentylene)-bis-(-)-nor-MEP DMBPC0K MI TTEB0GD DMBPC0K MN Cholinesterase (BCHE) DMBPC0K MT DTT DMBPC0K MA Inhibitor DMBPC0K RN Bis-(-)-nor-meptazinols as novel nanomolar cholinesterase inhibitors with high inhibitory potency on amyloid-beta aggregation. J Med Chem. 2008 Apr 10;51(7):2027-36. DMBPC0K RU https://pubmed.ncbi.nlm.nih.gov/18333606 DMU4BIW DI DMU4BIW DMU4BIW DN N,N'-(1',6-hexylene)-bis-(-)-nor-MEP DMU4BIW MI TT1RS9F DMU4BIW MN Acetylcholinesterase (AChE) DMU4BIW MT DTT DMU4BIW MA Inhibitor DMU4BIW RN Bis-(-)-nor-meptazinols as novel nanomolar cholinesterase inhibitors with high inhibitory potency on amyloid-beta aggregation. J Med Chem. 2008 Apr 10;51(7):2027-36. DMU4BIW RU https://pubmed.ncbi.nlm.nih.gov/18333606 DMU4BIW DI DMU4BIW DMU4BIW DN N,N'-(1',6-hexylene)-bis-(-)-nor-MEP DMU4BIW MI TTEB0GD DMU4BIW MN Cholinesterase (BCHE) DMU4BIW MT DTT DMU4BIW MA Inhibitor DMU4BIW RN Bis-(-)-nor-meptazinols as novel nanomolar cholinesterase inhibitors with high inhibitory potency on amyloid-beta aggregation. J Med Chem. 2008 Apr 10;51(7):2027-36. DMU4BIW RU https://pubmed.ncbi.nlm.nih.gov/18333606 DMSORHA DI DMSORHA DMSORHA DN N,N'-(1',7'-heptylene)-bis-(-)-nor-MEP DMSORHA MI TT1RS9F DMSORHA MN Acetylcholinesterase (AChE) DMSORHA MT DTT DMSORHA MA Inhibitor DMSORHA RN Bis-(-)-nor-meptazinols as novel nanomolar cholinesterase inhibitors with high inhibitory potency on amyloid-beta aggregation. J Med Chem. 2008 Apr 10;51(7):2027-36. DMSORHA RU https://pubmed.ncbi.nlm.nih.gov/18333606 DMSORHA DI DMSORHA DMSORHA DN N,N'-(1',7'-heptylene)-bis-(-)-nor-MEP DMSORHA MI TTEB0GD DMSORHA MN Cholinesterase (BCHE) DMSORHA MT DTT DMSORHA MA Inhibitor DMSORHA RN Bis-(-)-nor-meptazinols as novel nanomolar cholinesterase inhibitors with high inhibitory potency on amyloid-beta aggregation. J Med Chem. 2008 Apr 10;51(7):2027-36. DMSORHA RU https://pubmed.ncbi.nlm.nih.gov/18333606 DMHFYK2 DI DMHFYK2 DMHFYK2 DN N,N'-(1',8'-octylene)-bis-(-)-nor-MEP DMHFYK2 MI TT1RS9F DMHFYK2 MN Acetylcholinesterase (AChE) DMHFYK2 MT DTT DMHFYK2 MA Inhibitor DMHFYK2 RN Bis-(-)-nor-meptazinols as novel nanomolar cholinesterase inhibitors with high inhibitory potency on amyloid-beta aggregation. J Med Chem. 2008 Apr 10;51(7):2027-36. DMHFYK2 RU https://pubmed.ncbi.nlm.nih.gov/18333606 DMHFYK2 DI DMHFYK2 DMHFYK2 DN N,N'-(1',8'-octylene)-bis-(-)-nor-MEP DMHFYK2 MI TTEB0GD DMHFYK2 MN Cholinesterase (BCHE) DMHFYK2 MT DTT DMHFYK2 MA Inhibitor DMHFYK2 RN Bis-(-)-nor-meptazinols as novel nanomolar cholinesterase inhibitors with high inhibitory potency on amyloid-beta aggregation. J Med Chem. 2008 Apr 10;51(7):2027-36. DMHFYK2 RU https://pubmed.ncbi.nlm.nih.gov/18333606 DMIWF7U DI DMIWF7U DMIWF7U DN N,N'-(1',9'-nonylene)-bis-(-)-nor-MEP DMIWF7U MI TT1RS9F DMIWF7U MN Acetylcholinesterase (AChE) DMIWF7U MT DTT DMIWF7U MA Inhibitor DMIWF7U RN Bis-(-)-nor-meptazinols as novel nanomolar cholinesterase inhibitors with high inhibitory potency on amyloid-beta aggregation. J Med Chem. 2008 Apr 10;51(7):2027-36. DMIWF7U RU https://pubmed.ncbi.nlm.nih.gov/18333606 DMIWF7U DI DMIWF7U DMIWF7U DN N,N'-(1',9'-nonylene)-bis-(-)-nor-MEP DMIWF7U MI TTEB0GD DMIWF7U MN Cholinesterase (BCHE) DMIWF7U MT DTT DMIWF7U MA Inhibitor DMIWF7U RN Bis-(-)-nor-meptazinols as novel nanomolar cholinesterase inhibitors with high inhibitory potency on amyloid-beta aggregation. J Med Chem. 2008 Apr 10;51(7):2027-36. DMIWF7U RU https://pubmed.ncbi.nlm.nih.gov/18333606 DMLU27Y DI DMLU27Y DMLU27Y DN N,N,N-Triisobutyl-pyrimidine-2,4,6-triamine DMLU27Y MI TTZAYWL DMLU27Y MN Estrogen receptor (ESR) DMLU27Y MT DTT DMLU27Y MA Inhibitor DMLU27Y RN Blocking estrogen signaling after the hormone: pyrimidine-core inhibitors of estrogen receptor-coactivator binding. J Med Chem. 2008 Oct 23;51(20):6512-30. DMLU27Y RU https://pubmed.ncbi.nlm.nih.gov/18785725 DMNZKCL DI DMNZKCL DMNZKCL DN N,N`-bis-alkyl butylimmidazole 12b DMNZKCL MI TT8DBY3 DMNZKCL MN Angiotensin II receptor type-1 (AGTR1) DMNZKCL MT DTT DMNZKCL MA Antagonist DMNZKCL RN Rational design, efficient syntheses and biological evaluation of N,N'-symmetrically bis-substituted butylimidazole analogs as a new class of potent Angiotensin II receptor blockers. Eur J Med Chem. 2013 Apr;62:352-70. DMNZKCL RU https://pubmed.ncbi.nlm.nih.gov/23376252 DMT4USP DI DMT4USP DMT4USP DN N,N'-Bis(4-Amino-2-Methylquinolin-6-Yl)Urea DMT4USP MI TTIQSC1 DMT4USP MN Bacterial Lethal factor (Bact lef) DMT4USP MT DTT DMT4USP MA Inhibitor DMT4USP RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMT4USP RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMLOP2B DI DMLOP2B DMLOP2B DN N,N'-Bis-(4-butoxy-phenyl)-guanidine DMLOP2B MI TTLD29N DMLOP2B MN Glutamate receptor ionotropic NMDA 1 (NMDAR1) DMLOP2B MT DTT DMLOP2B MA Inhibitor DMLOP2B RN Synthesis and pharmacological evaluation of N,N'-diarylguanidines as potent sodium channel blockers and anticonvulsant agents. J Med Chem. 1998 Aug 13;41(17):3298-302. DMLOP2B RU https://pubmed.ncbi.nlm.nih.gov/9703475 DMLOP2B DI DMLOP2B DMLOP2B DN N,N'-Bis-(4-butoxy-phenyl)-guanidine DMLOP2B MI TTKJEMQ DMLOP2B MN Glutamate receptor ionotropic NMDA 2A (NMDAR2A) DMLOP2B MT DTT DMLOP2B MA Inhibitor DMLOP2B RN Synthesis and pharmacological evaluation of N,N'-diarylguanidines as potent sodium channel blockers and anticonvulsant agents. J Med Chem. 1998 Aug 13;41(17):3298-302. DMLOP2B RU https://pubmed.ncbi.nlm.nih.gov/9703475 DMLOP2B DI DMLOP2B DMLOP2B DN N,N'-Bis-(4-butoxy-phenyl)-guanidine DMLOP2B MI TTN9D8E DMLOP2B MN Glutamate receptor ionotropic NMDA 2B (NMDAR2B) DMLOP2B MT DTT DMLOP2B MA Inhibitor DMLOP2B RN Synthesis and pharmacological evaluation of N,N'-diarylguanidines as potent sodium channel blockers and anticonvulsant agents. J Med Chem. 1998 Aug 13;41(17):3298-302. DMLOP2B RU https://pubmed.ncbi.nlm.nih.gov/9703475 DMOS2GH DI DMOS2GH DMOS2GH DN N,N'-Bis-(4-butyl-phenyl)-guanidine DMOS2GH MI TTLD29N DMOS2GH MN Glutamate receptor ionotropic NMDA 1 (NMDAR1) DMOS2GH MT DTT DMOS2GH MA Inhibitor DMOS2GH RN Synthesis and pharmacological evaluation of N,N'-diarylguanidines as potent sodium channel blockers and anticonvulsant agents. J Med Chem. 1998 Aug 13;41(17):3298-302. DMOS2GH RU https://pubmed.ncbi.nlm.nih.gov/9703475 DMOS2GH DI DMOS2GH DMOS2GH DN N,N'-Bis-(4-butyl-phenyl)-guanidine DMOS2GH MI TTKJEMQ DMOS2GH MN Glutamate receptor ionotropic NMDA 2A (NMDAR2A) DMOS2GH MT DTT DMOS2GH MA Inhibitor DMOS2GH RN Synthesis and pharmacological evaluation of N,N'-diarylguanidines as potent sodium channel blockers and anticonvulsant agents. J Med Chem. 1998 Aug 13;41(17):3298-302. DMOS2GH RU https://pubmed.ncbi.nlm.nih.gov/9703475 DMOS2GH DI DMOS2GH DMOS2GH DN N,N'-Bis-(4-butyl-phenyl)-guanidine DMOS2GH MI TTN9D8E DMOS2GH MN Glutamate receptor ionotropic NMDA 2B (NMDAR2B) DMOS2GH MT DTT DMOS2GH MA Inhibitor DMOS2GH RN Synthesis and pharmacological evaluation of N,N'-diarylguanidines as potent sodium channel blockers and anticonvulsant agents. J Med Chem. 1998 Aug 13;41(17):3298-302. DMOS2GH RU https://pubmed.ncbi.nlm.nih.gov/9703475 DM0CTG7 DI DM0CTG7 DM0CTG7 DN N,N'-Bis-(4-ethyl-phenyl)-guanidine DM0CTG7 MI TTLD29N DM0CTG7 MN Glutamate receptor ionotropic NMDA 1 (NMDAR1) DM0CTG7 MT DTT DM0CTG7 MA Inhibitor DM0CTG7 RN Synthesis and pharmacological evaluation of N,N'-diarylguanidines as potent sodium channel blockers and anticonvulsant agents. J Med Chem. 1998 Aug 13;41(17):3298-302. DM0CTG7 RU https://pubmed.ncbi.nlm.nih.gov/9703475 DM0CTG7 DI DM0CTG7 DM0CTG7 DN N,N'-Bis-(4-ethyl-phenyl)-guanidine DM0CTG7 MI TTKJEMQ DM0CTG7 MN Glutamate receptor ionotropic NMDA 2A (NMDAR2A) DM0CTG7 MT DTT DM0CTG7 MA Inhibitor DM0CTG7 RN Synthesis and pharmacological evaluation of N,N'-diarylguanidines as potent sodium channel blockers and anticonvulsant agents. J Med Chem. 1998 Aug 13;41(17):3298-302. DM0CTG7 RU https://pubmed.ncbi.nlm.nih.gov/9703475 DM0CTG7 DI DM0CTG7 DM0CTG7 DN N,N'-Bis-(4-ethyl-phenyl)-guanidine DM0CTG7 MI TTN9D8E DM0CTG7 MN Glutamate receptor ionotropic NMDA 2B (NMDAR2B) DM0CTG7 MT DTT DM0CTG7 MA Inhibitor DM0CTG7 RN Synthesis and pharmacological evaluation of N,N'-diarylguanidines as potent sodium channel blockers and anticonvulsant agents. J Med Chem. 1998 Aug 13;41(17):3298-302. DM0CTG7 RU https://pubmed.ncbi.nlm.nih.gov/9703475 DM0RQGU DI DM0RQGU DM0RQGU DN N,N'-Bis-(4-hexyl-phenyl)-guanidine DM0RQGU MI TTLD29N DM0RQGU MN Glutamate receptor ionotropic NMDA 1 (NMDAR1) DM0RQGU MT DTT DM0RQGU MA Inhibitor DM0RQGU RN Synthesis and pharmacological evaluation of N,N'-diarylguanidines as potent sodium channel blockers and anticonvulsant agents. J Med Chem. 1998 Aug 13;41(17):3298-302. DM0RQGU RU https://pubmed.ncbi.nlm.nih.gov/9703475 DM0RQGU DI DM0RQGU DM0RQGU DN N,N'-Bis-(4-hexyl-phenyl)-guanidine DM0RQGU MI TTKJEMQ DM0RQGU MN Glutamate receptor ionotropic NMDA 2A (NMDAR2A) DM0RQGU MT DTT DM0RQGU MA Inhibitor DM0RQGU RN Synthesis and pharmacological evaluation of N,N'-diarylguanidines as potent sodium channel blockers and anticonvulsant agents. J Med Chem. 1998 Aug 13;41(17):3298-302. DM0RQGU RU https://pubmed.ncbi.nlm.nih.gov/9703475 DM0RQGU DI DM0RQGU DM0RQGU DN N,N'-Bis-(4-hexyl-phenyl)-guanidine DM0RQGU MI TTN9D8E DM0RQGU MN Glutamate receptor ionotropic NMDA 2B (NMDAR2B) DM0RQGU MT DTT DM0RQGU MA Inhibitor DM0RQGU RN Synthesis and pharmacological evaluation of N,N'-diarylguanidines as potent sodium channel blockers and anticonvulsant agents. J Med Chem. 1998 Aug 13;41(17):3298-302. DM0RQGU RU https://pubmed.ncbi.nlm.nih.gov/9703475 DMM38BC DI DMM38BC DMM38BC DN N,N'-Bis-(4-isopropyl-phenyl)-guanidine DMM38BC MI TTLD29N DMM38BC MN Glutamate receptor ionotropic NMDA 1 (NMDAR1) DMM38BC MT DTT DMM38BC MA Inhibitor DMM38BC RN Synthesis and pharmacological evaluation of N,N'-diarylguanidines as potent sodium channel blockers and anticonvulsant agents. J Med Chem. 1998 Aug 13;41(17):3298-302. DMM38BC RU https://pubmed.ncbi.nlm.nih.gov/9703475 DMM38BC DI DMM38BC DMM38BC DN N,N'-Bis-(4-isopropyl-phenyl)-guanidine DMM38BC MI TTKJEMQ DMM38BC MN Glutamate receptor ionotropic NMDA 2A (NMDAR2A) DMM38BC MT DTT DMM38BC MA Inhibitor DMM38BC RN Synthesis and pharmacological evaluation of N,N'-diarylguanidines as potent sodium channel blockers and anticonvulsant agents. J Med Chem. 1998 Aug 13;41(17):3298-302. DMM38BC RU https://pubmed.ncbi.nlm.nih.gov/9703475 DMM38BC DI DMM38BC DMM38BC DN N,N'-Bis-(4-isopropyl-phenyl)-guanidine DMM38BC MI TTN9D8E DMM38BC MN Glutamate receptor ionotropic NMDA 2B (NMDAR2B) DMM38BC MT DTT DMM38BC MA Inhibitor DMM38BC RN Synthesis and pharmacological evaluation of N,N'-diarylguanidines as potent sodium channel blockers and anticonvulsant agents. J Med Chem. 1998 Aug 13;41(17):3298-302. DMM38BC RU https://pubmed.ncbi.nlm.nih.gov/9703475 DMFDXLB DI DMFDXLB DMFDXLB DN N,N'-Bis-(4-sec-butyl-phenyl)-guanidine DMFDXLB MI TTLD29N DMFDXLB MN Glutamate receptor ionotropic NMDA 1 (NMDAR1) DMFDXLB MT DTT DMFDXLB MA Inhibitor DMFDXLB RN Synthesis and pharmacological evaluation of N,N'-diarylguanidines as potent sodium channel blockers and anticonvulsant agents. J Med Chem. 1998 Aug 13;41(17):3298-302. DMFDXLB RU https://pubmed.ncbi.nlm.nih.gov/9703475 DMFDXLB DI DMFDXLB DMFDXLB DN N,N'-Bis-(4-sec-butyl-phenyl)-guanidine DMFDXLB MI TTKJEMQ DMFDXLB MN Glutamate receptor ionotropic NMDA 2A (NMDAR2A) DMFDXLB MT DTT DMFDXLB MA Inhibitor DMFDXLB RN Synthesis and pharmacological evaluation of N,N'-diarylguanidines as potent sodium channel blockers and anticonvulsant agents. J Med Chem. 1998 Aug 13;41(17):3298-302. DMFDXLB RU https://pubmed.ncbi.nlm.nih.gov/9703475 DMFDXLB DI DMFDXLB DMFDXLB DN N,N'-Bis-(4-sec-butyl-phenyl)-guanidine DMFDXLB MI TTN9D8E DMFDXLB MN Glutamate receptor ionotropic NMDA 2B (NMDAR2B) DMFDXLB MT DTT DMFDXLB MA Inhibitor DMFDXLB RN Synthesis and pharmacological evaluation of N,N'-diarylguanidines as potent sodium channel blockers and anticonvulsant agents. J Med Chem. 1998 Aug 13;41(17):3298-302. DMFDXLB RU https://pubmed.ncbi.nlm.nih.gov/9703475 DMBQ0TY DI DMBQ0TY DMBQ0TY DN N,N-bis(cyanomethyl)-3,4-dimethoxybenzamide DMBQ0TY MI TTPLTSQ DMBQ0TY MN Neutrophil elastase (NE) DMBQ0TY MT DTT DMBQ0TY MA Inhibitor DMBQ0TY RN N-benzoylpyrazoles are novel small-molecule inhibitors of human neutrophil elastase. J Med Chem. 2007 Oct 4;50(20):4928-38. DMBQ0TY RU https://pubmed.ncbi.nlm.nih.gov/17850059 DMM678B DI DMM678B DMM678B DN N,N-bis(tosylmethyl)hexan-1-amine DMM678B MI TTX4RTB DMM678B MN Melanin-concentrating hormone receptor 1 (MCHR1) DMM678B MT DTT DMM678B MA Inhibitor DMM678B RN Discovery of novel chemotypes to a G-protein-coupled receptor through ligand-steered homology modeling and structure-based virtual screening. J Med Chem. 2008 Feb 14;51(3):581-8. DMM678B RU https://pubmed.ncbi.nlm.nih.gov/18198821 DM8TA0M DI DM8TA0M DM8TA0M DN N,N'-Di-acenaphthen-5-yl-guanidine DM8TA0M MI TT7RGTM DM8TA0M MN Voltage-gated calcium channel alpha Cav1.3 (CACNA1D) DM8TA0M MT DTT DM8TA0M MA Inhibitor DM8TA0M RN Synthesis and characterization of N-(acenaphth-5-yl)-N'-(4-methoxynaphth-1-yl)guanidine as a glutamate release inhibitor and potential anti-ischemic agent, Bioorg. Med. Chem. Lett. 5(19):2259-2262 (1995). DM8TA0M RU http://www.sciencedirect.com/science/article/pii/0960894X95003927 DMSY571 DI DMSY571 DMSY571 DN N,N-diallyl[D-Pro-10]Dyn A-(1-11) DMSY571 MI TTQW87Y DMSY571 MN Opioid receptor kappa (OPRK1) DMSY571 MT DTT DMSY571 MA Inhibitor DMSY571 RN Synthesis and opioid activity of [D-Pro10]dynorphin A-(1-11) analogues with N-terminal alkyl substitution. J Med Chem. 1997 Aug 15;40(17):2733-9. DMSY571 RU https://pubmed.ncbi.nlm.nih.gov/9276018 DMILJUE DI DMILJUE DMILJUE DN N,N-dibenzyl[D-Pro-10]Dyn A-(1-11) DMILJUE MI TTQW87Y DMILJUE MN Opioid receptor kappa (OPRK1) DMILJUE MT DTT DMILJUE MA Inhibitor DMILJUE RN Synthesis and opioid activity of [D-Pro10]dynorphin A-(1-11) analogues with N-terminal alkyl substitution. J Med Chem. 1997 Aug 15;40(17):2733-9. DMILJUE RU https://pubmed.ncbi.nlm.nih.gov/9276018 DM1UCZ9 DI DM1UCZ9 DM1UCZ9 DN N,N-diCPM[D-Pro-10]Dyn A-(1-11) DM1UCZ9 MI TTQW87Y DM1UCZ9 MN Opioid receptor kappa (OPRK1) DM1UCZ9 MT DTT DM1UCZ9 MA Inhibitor DM1UCZ9 RN Synthesis and opioid activity of [D-Pro10]dynorphin A-(1-11) analogues with N-terminal alkyl substitution. J Med Chem. 1997 Aug 15;40(17):2733-9. DM1UCZ9 RU https://pubmed.ncbi.nlm.nih.gov/9276018 DMLVMJH DI DMLVMJH DMLVMJH DN N,N'-dicyclohexyl-urea DMLVMJH MI TT7WVHI DMLVMJH MN Soluble epoxide hydrolase (EPHX2) DMLVMJH MT DTT DMLVMJH MA Inhibitor DMLVMJH RN Orally bioavailable potent soluble epoxide hydrolase inhibitors. J Med Chem. 2007 Aug 9;50(16):3825-40. DMLVMJH RU https://pubmed.ncbi.nlm.nih.gov/17616115 DMZ3EA1 DI DMZ3EA1 DMZ3EA1 DN N,N-diethyl estrone-16-methyl carboxamide DMZ3EA1 MI TTIWB6L DMZ3EA1 MN Estradiol 17 beta-dehydrogenase 1 (17-beta-HSD1) DMZ3EA1 MT DTT DMZ3EA1 MA Inhibitor DMZ3EA1 RN Modification of estrone at the 6, 16, and 17 positions: novel potent inhibitors of 17beta-hydroxysteroid dehydrogenase type 1. J Med Chem. 2006 Feb 23;49(4):1325-45. DMZ3EA1 RU https://pubmed.ncbi.nlm.nih.gov/16480268 DM5K3D2 DI DM5K3D2 DM5K3D2 DN N,N-Diethyl-1'H-phenothiazine-1'-carboxamide DM5K3D2 MI TTEB0GD DM5K3D2 MN Cholinesterase (BCHE) DM5K3D2 MT DTT DM5K3D2 MA Inhibitor DM5K3D2 RN Differential binding of phenothiazine urea derivatives to wild-type human cholinesterases and butyrylcholinesterase mutants. Bioorg Med Chem. 2010 Mar 15;18(6):2232-2244. DM5K3D2 RU https://pubmed.ncbi.nlm.nih.gov/20181484 DM0UBI9 DI DM0UBI9 DM0UBI9 DN N,N-diethyl-2-(1H-indol-3-yl)ethanamine DM0UBI9 MI TTJS8PY DM0UBI9 MN 5-HT 6 receptor (HTR6) DM0UBI9 MT DTT DM0UBI9 MA Inhibitor DM0UBI9 RN Interaction of N1-unsubstituted and N1-benzenesulfonyltryptamines at h5-HT6 receptors. Bioorg Med Chem Lett. 2006 Nov 15;16(22):5832-5. DM0UBI9 RU https://pubmed.ncbi.nlm.nih.gov/16945532 DMBFASY DI DMBFASY DMBFASY DN N,N-Diethyl-2-(2-phenyl-1H-indol-3-yl)-acetamide DMBFASY MI TTPTXIN DMBFASY MN Translocator protein (TSPO) DMBFASY MT DTT DMBFASY MA Inhibitor DMBFASY RN Chemistry, binding affinities, and behavioral properties of a new class of "antineophobic" mitochondrial DBI receptor complex (mDRC) ligands. J Med Chem. 1993 Oct 1;36(20):2908-20. DMBFASY RU https://pubmed.ncbi.nlm.nih.gov/8411007 DMV8QTR DI DMV8QTR DMV8QTR DN N,N-Dihexyl-2-(2-phenyl-1H-indol-3-yl)-acetamide DMV8QTR MI TTPTXIN DMV8QTR MN Translocator protein (TSPO) DMV8QTR MT DTT DMV8QTR MA Inhibitor DMV8QTR RN Chemistry, binding affinities, and behavioral properties of a new class of "antineophobic" mitochondrial DBI receptor complex (mDRC) ligands. J Med Chem. 1993 Oct 1;36(20):2908-20. DMV8QTR RU https://pubmed.ncbi.nlm.nih.gov/8411007 DM4E8C9 DI DM4E8C9 DM4E8C9 DN N,N-Diisopropyl-1'H-phenothiazine-1'-carboxamide DM4E8C9 MI TTEB0GD DM4E8C9 MN Cholinesterase (BCHE) DM4E8C9 MT DTT DM4E8C9 MA Inhibitor DM4E8C9 RN Differential binding of phenothiazine urea derivatives to wild-type human cholinesterases and butyrylcholinesterase mutants. Bioorg Med Chem. 2010 Mar 15;18(6):2232-2244. DM4E8C9 RU https://pubmed.ncbi.nlm.nih.gov/20181484 DMTWK7L DI DMTWK7L DMTWK7L DN N,Ndimethyl milnacipran DMTWK7L MI TTVBI8W DMTWK7L MN Dopamine transporter (DAT) DMTWK7L MT DTT DMTWK7L MA Inhibitor DMTWK7L RN Studies on the SAR and pharmacophore of milnacipran derivatives as monoamine transporter inhibitors. Bioorg Med Chem Lett. 2008 Feb 15;18(4):1346-9. DMTWK7L RU https://pubmed.ncbi.nlm.nih.gov/18207394 DMWK91T DI DMWK91T DMWK91T DN N,N-dimethyl(2-phenoxyphenyl)methanamine DMWK91T MI TTAWNKZ DMWK91T MN Norepinephrine transporter (NET) DMWK91T MT DTT DMWK91T MA Inhibitor DMWK91T RN 1-(2-Phenoxyphenyl)methanamines: SAR for dual serotonin/noradrenaline reuptake inhibition, metabolic stability and hERG affinity. Bioorg Med Chem Lett. 2008 Jan 15;18(2):596-9. DMWK91T RU https://pubmed.ncbi.nlm.nih.gov/18240382 DMWK91T DI DMWK91T DMWK91T DN N,N-dimethyl(2-phenoxyphenyl)methanamine DMWK91T MI TT3ROYC DMWK91T MN Serotonin transporter (SERT) DMWK91T MT DTT DMWK91T MA Inhibitor DMWK91T RN 1-(2-Phenoxyphenyl)methanamines: SAR for dual serotonin/noradrenaline reuptake inhibition, metabolic stability and hERG affinity. Bioorg Med Chem Lett. 2008 Jan 15;18(2):596-9. DMWK91T RU https://pubmed.ncbi.nlm.nih.gov/18240382 DM41C8E DI DM41C8E DM41C8E DN N,N-dimethyl(pyridin-3-yl)methanamine DM41C8E MI TT4H1MQ DM41C8E MN Neuronal acetylcholine receptor alpha-4 (CHRNA4) DM41C8E MT DTT DM41C8E MA Inhibitor DM41C8E RN Synthesis and analgesic activity of secondary amine analogues of pyridylmethylamine and positional isomeric analogues of ABT-594. Bioorg Med Chem Lett. 2006 Apr 1;16(7):2013-6. DM41C8E RU https://pubmed.ncbi.nlm.nih.gov/16412637 DM41C8E DI DM41C8E DM41C8E DN N,N-dimethyl(pyridin-3-yl)methanamine DM41C8E MI TT5KPZR DM41C8E MN Neuronal acetylcholine receptor beta-2 (CHRNB2) DM41C8E MT DTT DM41C8E MA Inhibitor DM41C8E RN Synthesis and analgesic activity of secondary amine analogues of pyridylmethylamine and positional isomeric analogues of ABT-594. Bioorg Med Chem Lett. 2006 Apr 1;16(7):2013-6. DM41C8E RU https://pubmed.ncbi.nlm.nih.gov/16412637 DM4CDYG DI DM4CDYG DM4CDYG DN N,N-Dimethyl-1'H-phenothiazine-1'-carboxamide DM4CDYG MI TTEB0GD DM4CDYG MN Cholinesterase (BCHE) DM4CDYG MT DTT DM4CDYG MA Inhibitor DM4CDYG RN Differential binding of phenothiazine urea derivatives to wild-type human cholinesterases and butyrylcholinesterase mutants. Bioorg Med Chem. 2010 Mar 15;18(6):2232-2244. DM4CDYG RU https://pubmed.ncbi.nlm.nih.gov/20181484 DMYUQDK DI DMYUQDK DMYUQDK DN N,N-dimethyl-2-(1-tosyl-1H-indol-3-yl)ethanamine DMYUQDK MI TTJS8PY DMYUQDK MN 5-HT 6 receptor (HTR6) DMYUQDK MT DTT DMYUQDK MA Inhibitor DMYUQDK RN Further studies on the binding of N1-substituted tryptamines at h5-HT6 receptors. Bioorg Med Chem Lett. 2007 Mar 15;17(6):1691-4. DMYUQDK RU https://pubmed.ncbi.nlm.nih.gov/17239595 DM1DZEL DI DM1DZEL DM1DZEL DN N,N-dimethyl-2-(2'-methylbiphenyl-3-yl)ethanamine DM1DZEL MI TTO9X1H DM1DZEL MN 5-HT 7 receptor (HTR7) DM1DZEL MT DTT DM1DZEL MA Inhibitor DM1DZEL RN SAR studies on new bis-aryls 5-HT7 ligands: Synthesis and molecular modeling. Bioorg Med Chem. 2010 Mar 1;18(5):1958-67. DM1DZEL RU https://pubmed.ncbi.nlm.nih.gov/20138771 DM73PXI DI DM73PXI DM73PXI DN N,N-Dimethyl-2-(2-phenyl-1H-indol-3-yl)-acetamide DM73PXI MI TTPTXIN DM73PXI MN Translocator protein (TSPO) DM73PXI MT DTT DM73PXI MA Inhibitor DM73PXI RN Chemistry, binding affinities, and behavioral properties of a new class of "antineophobic" mitochondrial DBI receptor complex (mDRC) ligands. J Med Chem. 1993 Oct 1;36(20):2908-20. DM73PXI RU https://pubmed.ncbi.nlm.nih.gov/8411007 DMMD9A0 DI DMMD9A0 DMMD9A0 DN N,N-dimethyl-2-(pyridin-3-yloxy)ethanamine DMMD9A0 MI TT4H1MQ DMMD9A0 MN Neuronal acetylcholine receptor alpha-4 (CHRNA4) DMMD9A0 MT DTT DMMD9A0 MA Inhibitor DMMD9A0 RN Synthesis and analgesic activity of secondary amine analogues of pyridylmethylamine and positional isomeric analogues of ABT-594. Bioorg Med Chem Lett. 2006 Apr 1;16(7):2013-6. DMMD9A0 RU https://pubmed.ncbi.nlm.nih.gov/16412637 DMMD9A0 DI DMMD9A0 DMMD9A0 DN N,N-dimethyl-2-(pyridin-3-yloxy)ethanamine DMMD9A0 MI TT5KPZR DMMD9A0 MN Neuronal acetylcholine receptor beta-2 (CHRNB2) DMMD9A0 MT DTT DMMD9A0 MA Inhibitor DMMD9A0 RN Synthesis and analgesic activity of secondary amine analogues of pyridylmethylamine and positional isomeric analogues of ABT-594. Bioorg Med Chem Lett. 2006 Apr 1;16(7):2013-6. DMMD9A0 RU https://pubmed.ncbi.nlm.nih.gov/16412637 DM9XZJN DI DM9XZJN DM9XZJN DN N,N-dimethyl-2,2,2-triphenylacetamide DM9XZJN MI TTMNI76 DM9XZJN MN Calcium-activated potassium channel (KCN) DM9XZJN MT DTT DM9XZJN MA Inhibitor DM9XZJN RN Novel inhibitors of the Gardos channel for the treatment of sickle cell disease. J Med Chem. 2008 Feb 28;51(4):976-82. DM9XZJN RU https://pubmed.ncbi.nlm.nih.gov/18232633 DMJDQGR DI DMJDQGR DMJDQGR DN N,N-dimethyl-2,2-diphenylethanamine DMJDQGR MI TTJQOD7 DMJDQGR MN 5-HT 2A receptor (HTR2A) DMJDQGR MT DTT DMJDQGR MA Inhibitor DMJDQGR RN Synthesis, structure-affinity relationships, and modeling of AMDA analogs at 5-HT2A and H1 receptors: structural factors contributing to selectivity. Bioorg Med Chem. 2009 Sep 15;17(18):6496-504. DMJDQGR RU https://pubmed.ncbi.nlm.nih.gov/19700330 DMJDQGR DI DMJDQGR DMJDQGR DN N,N-dimethyl-2,2-diphenylethanamine DMJDQGR MI TTTIBOJ DMJDQGR MN Histamine H1 receptor (H1R) DMJDQGR MT DTT DMJDQGR MA Inhibitor DMJDQGR RN Synthesis, structure-affinity relationships, and modeling of AMDA analogs at 5-HT2A and H1 receptors: structural factors contributing to selectivity. Bioorg Med Chem. 2009 Sep 15;17(18):6496-504. DMJDQGR RU https://pubmed.ncbi.nlm.nih.gov/19700330 DMIP5K7 DI DMIP5K7 DMIP5K7 DN N,N-Dimethyl-3,3-diphenylpropan-1-amine DMIP5K7 MI TTJQOD7 DMIP5K7 MN 5-HT 2A receptor (HTR2A) DMIP5K7 MT DTT DMIP5K7 MA Inhibitor DMIP5K7 RN Synthesis, structure-affinity relationships, and modeling of AMDA analogs at 5-HT2A and H1 receptors: structural factors contributing to selectivity. Bioorg Med Chem. 2009 Sep 15;17(18):6496-504. DMIP5K7 RU https://pubmed.ncbi.nlm.nih.gov/19700330 DMIP5K7 DI DMIP5K7 DMIP5K7 DN N,N-Dimethyl-3,3-diphenylpropan-1-amine DMIP5K7 MI TTTIBOJ DMIP5K7 MN Histamine H1 receptor (H1R) DMIP5K7 MT DTT DMIP5K7 MA Inhibitor DMIP5K7 RN Synthesis, structure-affinity relationships, and modeling of AMDA analogs at 5-HT2A and H1 receptors: structural factors contributing to selectivity. Bioorg Med Chem. 2009 Sep 15;17(18):6496-504. DMIP5K7 RU https://pubmed.ncbi.nlm.nih.gov/19700330 DMI3CUZ DI DMI3CUZ DMI3CUZ DN N,N-dimethyl-3,4-dihydroquinazolin-2-amine DMI3CUZ MI TTRUFDT DMI3CUZ MN 5-HT 5A receptor (HTR5A) DMI3CUZ MT DTT DMI3CUZ MA Inhibitor DMI3CUZ RN Cyclic guanidines as dual 5-HT5A/5-HT7 receptor ligands: structure-activity relationship elucidation. Bioorg Med Chem Lett. 2008 Jan 1;18(1):256-61. DMI3CUZ RU https://pubmed.ncbi.nlm.nih.gov/17998160 DMLX0PI DI DMLX0PI DMLX0PI DN N,N-dimethyl-4-(pyridin-3-yl)but-3-yn-1-amine DMLX0PI MI TT4H1MQ DMLX0PI MN Neuronal acetylcholine receptor alpha-4 (CHRNA4) DMLX0PI MT DTT DMLX0PI MA Inhibitor DMLX0PI RN Synthesis and analgesic activity of secondary amine analogues of pyridylmethylamine and positional isomeric analogues of ABT-594. Bioorg Med Chem Lett. 2006 Apr 1;16(7):2013-6. DMLX0PI RU https://pubmed.ncbi.nlm.nih.gov/16412637 DMLX0PI DI DMLX0PI DMLX0PI DN N,N-dimethyl-4-(pyridin-3-yl)but-3-yn-1-amine DMLX0PI MI TT5KPZR DMLX0PI MN Neuronal acetylcholine receptor beta-2 (CHRNB2) DMLX0PI MT DTT DMLX0PI MA Inhibitor DMLX0PI RN Synthesis and analgesic activity of secondary amine analogues of pyridylmethylamine and positional isomeric analogues of ABT-594. Bioorg Med Chem Lett. 2006 Apr 1;16(7):2013-6. DMLX0PI RU https://pubmed.ncbi.nlm.nih.gov/16412637 DMX9U7S DI DMX9U7S DMX9U7S DN N,N-dimethyl-4,4-diphenylbutan-1-amine DMX9U7S MI TTJQOD7 DMX9U7S MN 5-HT 2A receptor (HTR2A) DMX9U7S MT DTT DMX9U7S MA Inhibitor DMX9U7S RN Synthesis, structure-affinity relationships, and modeling of AMDA analogs at 5-HT2A and H1 receptors: structural factors contributing to selectivity. Bioorg Med Chem. 2009 Sep 15;17(18):6496-504. DMX9U7S RU https://pubmed.ncbi.nlm.nih.gov/19700330 DMX9U7S DI DMX9U7S DMX9U7S DN N,N-dimethyl-4,4-diphenylbutan-1-amine DMX9U7S MI TTTIBOJ DMX9U7S MN Histamine H1 receptor (H1R) DMX9U7S MT DTT DMX9U7S MA Inhibitor DMX9U7S RN Synthesis, structure-affinity relationships, and modeling of AMDA analogs at 5-HT2A and H1 receptors: structural factors contributing to selectivity. Bioorg Med Chem. 2009 Sep 15;17(18):6496-504. DMX9U7S RU https://pubmed.ncbi.nlm.nih.gov/19700330 DMWJ2PM DI DMWJ2PM DMWJ2PM DN N,N-Dimethylaminoethyl 18-methoxycoronaridinate DMWJ2PM MI TTTVAFQ DMWJ2PM MN Neuronal acetylcholine receptor beta-4 (CHRNB4) DMWJ2PM MT DTT DMWJ2PM MA Inhibitor DMWJ2PM RN Synthesis and biological evaluation of 18-methoxycoronaridine congeners. Potential antiaddiction agents. J Med Chem. 2003 Jun 19;46(13):2716-30. DMWJ2PM RU https://pubmed.ncbi.nlm.nih.gov/12801235 DM0Y8OW DI DM0Y8OW DM0Y8OW DN N,N-dimethylarginine DM0Y8OW MI TTCM4B3 DM0Y8OW MN Nitric-oxide synthase endothelial (NOS3) DM0Y8OW MT DTT DM0Y8OW MA Inhibitor DM0Y8OW RN Homocysteine and asymmetric dimethylarginine (ADMA): biochemically linked but differently related to vascular disease in chronic kidney disease. Clin Chem Lab Med. 2007;45(12):1683-7. DM0Y8OW RU https://pubmed.ncbi.nlm.nih.gov/17937610 DM0Y8OW DI DM0Y8OW DM0Y8OW DN N,N-dimethylarginine DM0Y8OW MI TTF10I9 DM0Y8OW MN Nitric-oxide synthase inducible (NOS2) DM0Y8OW MT DTT DM0Y8OW MA Inhibitor DM0Y8OW RN Homocysteine and asymmetric dimethylarginine (ADMA): biochemically linked but differently related to vascular disease in chronic kidney disease. Clin Chem Lab Med. 2007;45(12):1683-7. DM0Y8OW RU https://pubmed.ncbi.nlm.nih.gov/17937610 DM8WPD2 DI DM8WPD2 DM8WPD2 DN N,N-dimethylhistamine DM8WPD2 MI TTXJ178 DM8WPD2 MN Histamine H4 receptor (H4R) DM8WPD2 MT DTT DM8WPD2 MA Agonist DM8WPD2 RN Compared pharmacology of human histamine H3 and H4 receptors: structure-activity relationships of histamine derivatives. Br J Pharmacol. 2006 Apr;147(7):744-54. DM8WPD2 RU https://pubmed.ncbi.nlm.nih.gov/16432504 DM8769D DI DM8769D DM8769D DN N,N-Dipropyl-1'H-phenothiazine-1'-carboxamide DM8769D MI TTEB0GD DM8769D MN Cholinesterase (BCHE) DM8769D MT DTT DM8769D MA Inhibitor DM8769D RN Differential binding of phenothiazine urea derivatives to wild-type human cholinesterases and butyrylcholinesterase mutants. Bioorg Med Chem. 2010 Mar 15;18(6):2232-2244. DM8769D RU https://pubmed.ncbi.nlm.nih.gov/20181484 DMYCV7U DI DMYCV7U DMYCV7U DN N,O6-Disulfo-Glucosamine DMYCV7U MI TTGKIED DMYCV7U MN Fibroblast growth factor-2 (FGF2) DMYCV7U MT DTT DMYCV7U MA Inhibitor DMYCV7U RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMYCV7U RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMYCV7U DI DMYCV7U DMYCV7U DN N,O6-Disulfo-Glucosamine DMYCV7U MI TTMY81X DMYCV7U MN Heparin-binding growth factor 1 (FGF1) DMYCV7U MT DTT DMYCV7U MA Inhibitor DMYCV7U RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMYCV7U RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMYCV7U DI DMYCV7U DMYCV7U DN N,O6-Disulfo-Glucosamine DMYCV7U MI TT4V2JM DMYCV7U MN Hepatocyte growth factor (HGF) DMYCV7U MT DTT DMYCV7U MA Inhibitor DMYCV7U RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMYCV7U RU https://pubmed.ncbi.nlm.nih.gov/17139284 DM7FT8D DI DM7FT8D DM7FT8D DN N,O-Didansyl-L-Tyrosine DM7FT8D MI TTU6BFZ DM7FT8D MN Candida Thymidylate synthase (Candi TMP1) DM7FT8D MT DTT DM7FT8D MA Inhibitor DM7FT8D RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DM7FT8D RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMCGVAB DI DMCGVAB DMCGVAB DN N/OFQ-(1-13)-NH2 DMCGVAB MI TTNT7K8 DMCGVAB MN Nociceptin receptor (OPRL1) DMCGVAB MT DTT DMCGVAB MA Agonist DMCGVAB RN Address and message sequences for the nociceptin receptor: a structure-activity study of nociceptin-(1-13)-peptide amide. J Med Chem. 1997 Jun 6;40(12):1789-93. DMCGVAB RU https://pubmed.ncbi.nlm.nih.gov/9191955 DMLTYPS DI DMLTYPS DMLTYPS DN N-[(4-bromo-1-benzothien-3-yl)methyl]sulfamide DMLTYPS MI TTANPDJ DMLTYPS MN Carbonic anhydrase II (CA-II) DMLTYPS MT DTT DMLTYPS MA Inhibitor DMLTYPS RN Novel, broad-spectrum anticonvulsants containing a sulfamide group: advancement of N-((benzo[b]thien-3-yl)methyl)sulfamide (JNJ-26990990) into huma... J Med Chem. 2009 Dec 10;52(23):7528-36. DMLTYPS RU https://pubmed.ncbi.nlm.nih.gov/19388676 DMVOJFW DI DMVOJFW DMVOJFW DN N-[(4-methoxyphenyl)sulfonyl]-D-alanine DMVOJFW MI TTXZ0KQ DMVOJFW MN Matrix metalloproteinase-12 (MMP-12) DMVOJFW MT DTT DMVOJFW MA Inhibitor DMVOJFW RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DMVOJFW RU https://pubmed.ncbi.nlm.nih.gov/10592235 DMYJHRV DI DMYJHRV DMYJHRV DN N-[(5-chloro-1-benzothien-3-yl)methyl]sulfamide DMYJHRV MI TTANPDJ DMYJHRV MN Carbonic anhydrase II (CA-II) DMYJHRV MT DTT DMYJHRV MA Inhibitor DMYJHRV RN Novel, broad-spectrum anticonvulsants containing a sulfamide group: advancement of N-((benzo[b]thien-3-yl)methyl)sulfamide (JNJ-26990990) into huma... J Med Chem. 2009 Dec 10;52(23):7528-36. DMYJHRV RU https://pubmed.ncbi.nlm.nih.gov/19388676 DMHNR36 DI DMHNR36 DMHNR36 DN N-[(CYCLOHEXYLAMINO)CARBONYL]GLYCINE DMHNR36 MI TT7WVHI DMHNR36 MN Soluble epoxide hydrolase (EPHX2) DMHNR36 MT DTT DMHNR36 MA Inhibitor DMHNR36 RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DMHNR36 RU https://pubmed.ncbi.nlm.nih.gov/10592235 DMI9GQV DI DMI9GQV DMI9GQV DN N-[2-(1H-benzoimidazol-2-yl)-benzoyl]-guanidine DMI9GQV MI TTGSEFH DMI9GQV MN Sodium/hydrogen exchanger 1 (SLC9A1) DMI9GQV MT DTT DMI9GQV MA Inhibitor DMI9GQV RN Benzimidazol-2-yl or benzimidazol-2-ylthiomethyl benzoylguanidines as novel Na+/H+ exchanger inhibitors, synthesis and protection against ischemic-... Bioorg Med Chem Lett. 2007 May 1;17(9):2430-3. DMI9GQV RU https://pubmed.ncbi.nlm.nih.gov/17346962 DMM7T13 DI DMM7T13 DMM7T13 DN N-[2-(1h-Indol-5-Yl)-Butyl]-4-Sulfamoyl-Benzamide DMM7T13 MI TTANPDJ DMM7T13 MN Carbonic anhydrase II (CA-II) DMM7T13 MT DTT DMM7T13 MA Inhibitor DMM7T13 RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMM7T13 RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMPKBT1 DI DMPKBT1 DMPKBT1 DN N-[2-(4'-Nitrophenyl)ethyl]-imidazole DMPKBT1 MI TTSZLWK DMPKBT1 MN Aromatase (CYP19A1) DMPKBT1 MT DTT DMPKBT1 MA Inhibitor DMPKBT1 RN Pharmacophore modeling strategies for the development of novel nonsteroidal inhibitors of human aromatase (CYP19). Bioorg Med Chem Lett. 2010 May 15;20(10):3050-64. DMPKBT1 RU https://pubmed.ncbi.nlm.nih.gov/20413308 DM5FQH8 DI DM5FQH8 DM5FQH8 DN N-[2-(5-hydroxy-1H-indol-3-yl)ethyl]lauramide DM5FQH8 MI TTMI6F5 DM5FQH8 MN Transient receptor potential cation channel V1 (TRPV1) DM5FQH8 MT DTT DM5FQH8 MA Inhibitor DM5FQH8 RN New N-arachidonoylserotonin analogues with potential "dual" mechanism of action against pain. J Med Chem. 2007 Dec 27;50(26):6554-69. DM5FQH8 RU https://pubmed.ncbi.nlm.nih.gov/18027904 DMG5PL7 DI DMG5PL7 DMG5PL7 DN N-[2-(5-hydroxy-1H-indol-3-yl)ethyl]linoleamide DMG5PL7 MI TTMI6F5 DMG5PL7 MN Transient receptor potential cation channel V1 (TRPV1) DMG5PL7 MT DTT DMG5PL7 MA Inhibitor DMG5PL7 RN New N-arachidonoylserotonin analogues with potential "dual" mechanism of action against pain. J Med Chem. 2007 Dec 27;50(26):6554-69. DMG5PL7 RU https://pubmed.ncbi.nlm.nih.gov/18027904 DMC1GYH DI DMC1GYH DMC1GYH DN N-[2-(5-hydroxy-1H-indol-3-yl)ethyl]undecanamide DMC1GYH MI TTMI6F5 DMC1GYH MN Transient receptor potential cation channel V1 (TRPV1) DMC1GYH MT DTT DMC1GYH MA Inhibitor DMC1GYH RN New N-arachidonoylserotonin analogues with potential "dual" mechanism of action against pain. J Med Chem. 2007 Dec 27;50(26):6554-69. DMC1GYH RU https://pubmed.ncbi.nlm.nih.gov/18027904 DMJ8W6F DI DMJ8W6F DMJ8W6F DN N-[2-(Indol-3-yl)ethyl]-S-benzyl-dithiocarbamate DMJ8W6F MI TTZJYKH DMJ8W6F MN Indoleamine 2,3-dioxygenase 1 (IDO1) DMJ8W6F MT DTT DMJ8W6F MA Inhibitor DMJ8W6F RN Structure-activity study of brassinin derivatives as indoleamine 2,3-dioxygenase inhibitors. J Med Chem. 2006 Jan 26;49(2):684-92. DMJ8W6F RU https://pubmed.ncbi.nlm.nih.gov/16420054 DMU89FH DI DMU89FH DMU89FH DN N-[3-(2-Ethyl-benzooxazol-7-yl)-propyl]-acetamide DMU89FH MI TT32JK8 DMU89FH MN Melatonin receptor type 1B (MTNR1B) DMU89FH MT DTT DMU89FH MA Inhibitor DMU89FH RN Synthesis and structure-activity relationship of novel benzoxazole derivatives as melatonin receptor agonists. Bioorg Med Chem Lett. 2004 Jul 16;14(14):3799-802. DMU89FH RU https://pubmed.ncbi.nlm.nih.gov/15203165 DM7OA4R DI DM7OA4R DM7OA4R DN N-[3'-(trifluoromethyl)-4-biphenylyl]urea DM7OA4R MI TTBGTCW DM7OA4R MN Kinesin spindle messenger RNA (KIF11 mRNA) DM7OA4R MT DTT DM7OA4R MA Inhibitor DM7OA4R RN Novel ATP-competitive kinesin spindle protein inhibitors. J Med Chem. 2007 Oct 4;50(20):4939-52. DM7OA4R RU https://pubmed.ncbi.nlm.nih.gov/17725339 DMKPYEU DI DMKPYEU DMKPYEU DN N-[3,3-Bis-(4-fluorophenyl)-propyl]-benzamide DMKPYEU MI TT7WVHI DMKPYEU MN Soluble epoxide hydrolase (EPHX2) DMKPYEU MT DTT DMKPYEU MA Inhibitor DMKPYEU RN Structure-based optimization of arylamides as inhibitors of soluble epoxide hydrolase. J Med Chem. 2009 Oct 8;52(19):5880-95. DMKPYEU RU https://pubmed.ncbi.nlm.nih.gov/19746975 DMIP8AK DI DMIP8AK DMIP8AK DN N-[3,3-Bis-(4-fluorophenyl)-propyl]-nicotinamide DMIP8AK MI TT7WVHI DMIP8AK MN Soluble epoxide hydrolase (EPHX2) DMIP8AK MT DTT DMIP8AK MA Inhibitor DMIP8AK RN Structure-based optimization of arylamides as inhibitors of soluble epoxide hydrolase. J Med Chem. 2009 Oct 8;52(19):5880-95. DMIP8AK RU https://pubmed.ncbi.nlm.nih.gov/19746975 DMWDCV1 DI DMWDCV1 DMWDCV1 DN N-[3H]alpha-methylhistamine DMWDCV1 MI TT9JNIC DMWDCV1 MN Histamine H3 receptor (H3R) DMWDCV1 MT DTT DMWDCV1 MA Agonist DMWDCV1 RN Molecular and pharmacological characterization of the mouse histamine H3 receptor. Eur J Pharmacol. 2003 Apr 25;467(1-3):57-65. DMWDCV1 RU https://pubmed.ncbi.nlm.nih.gov/12706455 DMWDCV1 DI DMWDCV1 DMWDCV1 DN N-[3H]alpha-methylhistamine DMWDCV1 MI TTXJ178 DMWDCV1 MN Histamine H4 receptor (H4R) DMWDCV1 MT DTT DMWDCV1 MA Agonist DMWDCV1 RN Histamine induces cytoskeletal changes in human eosinophils via the H(4) receptor. Br J Pharmacol. 2003 Nov;140(6):1117-27. DMWDCV1 RU https://pubmed.ncbi.nlm.nih.gov/14530216 DM0CI4L DI DM0CI4L DM0CI4L DN N-[3H]methylhistamine DM0CI4L MI TT9JNIC DM0CI4L MN Histamine H3 receptor (H3R) DM0CI4L MT DTT DM0CI4L MA Agonist DM0CI4L RN Cloning and pharmacological characterization of a fourth histamine receptor (H(4)) expressed in bone marrow. Mol Pharmacol. 2001 Mar;59(3):420-6. DM0CI4L RU https://pubmed.ncbi.nlm.nih.gov/11179434 DM0CI4L DI DM0CI4L DM0CI4L DN N-[3H]methylhistamine DM0CI4L MI TTXJ178 DM0CI4L MN Histamine H4 receptor (H4R) DM0CI4L MT DTT DM0CI4L MA Agonist DM0CI4L RN Cloning and pharmacological characterization of a fourth histamine receptor (H(4)) expressed in bone marrow. Mol Pharmacol. 2001 Mar;59(3):420-6. DM0CI4L RU https://pubmed.ncbi.nlm.nih.gov/11179434 DMITN82 DI DMITN82 DMITN82 DN N-[4-(1,3-benzodioxol-5-yl)phenyl]sulfamide DMITN82 MI TTBGTCW DMITN82 MN Kinesin spindle messenger RNA (KIF11 mRNA) DMITN82 MT DTT DMITN82 MA Inhibitor DMITN82 RN Novel ATP-competitive kinesin spindle protein inhibitors. J Med Chem. 2007 Oct 4;50(20):4939-52. DMITN82 RU https://pubmed.ncbi.nlm.nih.gov/17725339 DMT6LX9 DI DMT6LX9 DMT6LX9 DN N-[4-(1H-benzoimidazol-2-yl)-benzoyl]-guanidine DMT6LX9 MI TTGSEFH DMT6LX9 MN Sodium/hydrogen exchanger 1 (SLC9A1) DMT6LX9 MT DTT DMT6LX9 MA Inhibitor DMT6LX9 RN Benzimidazol-2-yl or benzimidazol-2-ylthiomethyl benzoylguanidines as novel Na+/H+ exchanger inhibitors, synthesis and protection against ischemic-... Bioorg Med Chem Lett. 2007 May 1;17(9):2430-3. DMT6LX9 RU https://pubmed.ncbi.nlm.nih.gov/17346962 DMLV18K DI DMLV18K DMLV18K DN N-[4-(3-amino-1H-indazol-4-yl)phenyl]benzamide DMLV18K MI TTGJCWZ DMLV18K MN Fms-like tyrosine kinase 3 (FLT-3) DMLV18K MT DTT DMLV18K MA Inhibitor DMLV18K RN Discovery of N-(4-(3-amino-1H-indazol-4-yl)phenyl)-N'-(2-fluoro-5-methylphenyl)urea (ABT-869), a 3-aminoindazole-based orally active multitargeted ... J Med Chem. 2007 Apr 5;50(7):1584-97. DMLV18K RU https://pubmed.ncbi.nlm.nih.gov/17343372 DMC62K1 DI DMC62K1 DMC62K1 DN N-[4-(3-pyridylethynyl)-2-thiazolyl]acetamide DMC62K1 MI TTHS256 DMC62K1 MN Metabotropic glutamate receptor 5 (mGluR5) DMC62K1 MT DTT DMC62K1 MA Inhibitor DMC62K1 RN Synthesis and structure-activity relationships of 3-[(2-methyl-1,3-thiazol-4-yl)ethynyl]pyridine analogues as potent, noncompetitive metabotropic g... J Med Chem. 2006 Feb 9;49(3):1080-100. DMC62K1 RU https://pubmed.ncbi.nlm.nih.gov/16451073 DMA4L5P DI DMA4L5P DMA4L5P DN N-[4-(4-Phenyl-piperazin-1-yl)-butyl]-benzamide DMA4L5P MI TTSQIFT DMA4L5P MN 5-HT 1A receptor (HTR1A) DMA4L5P MT DTT DMA4L5P MA Inhibitor DMA4L5P RN Arylpiperazine derivatives as high-affinity 5-HT1A serotonin ligands. J Med Chem. 1988 Oct;31(10):1968-71. DMA4L5P RU https://pubmed.ncbi.nlm.nih.gov/3172131 DMD5F6Z DI DMD5F6Z DMD5F6Z DN N-[4'-(ethylsulfonyl)-3-fluoro-4-biphenylyl]urea DMD5F6Z MI TTBGTCW DMD5F6Z MN Kinesin spindle messenger RNA (KIF11 mRNA) DMD5F6Z MT DTT DMD5F6Z MA Inhibitor DMD5F6Z RN Novel ATP-competitive kinesin spindle protein inhibitors. J Med Chem. 2007 Oct 4;50(20):4939-52. DMD5F6Z RU https://pubmed.ncbi.nlm.nih.gov/17725339 DMCTZFP DI DMCTZFP DMCTZFP DN N-[4'-(trifluoromethyl)-4-biphenylyl]sulfamide DMCTZFP MI TTBGTCW DMCTZFP MN Kinesin spindle messenger RNA (KIF11 mRNA) DMCTZFP MT DTT DMCTZFP MA Inhibitor DMCTZFP RN Novel ATP-competitive kinesin spindle protein inhibitors. J Med Chem. 2007 Oct 4;50(20):4939-52. DMCTZFP RU https://pubmed.ncbi.nlm.nih.gov/17725339 DMPVKWG DI DMPVKWG DMPVKWG DN N-[4'-(trifluoromethyl)-4-biphenylyl]thiourea DMPVKWG MI TTBGTCW DMPVKWG MN Kinesin spindle messenger RNA (KIF11 mRNA) DMPVKWG MT DTT DMPVKWG MA Inhibitor DMPVKWG RN Novel ATP-competitive kinesin spindle protein inhibitors. J Med Chem. 2007 Oct 4;50(20):4939-52. DMPVKWG RU https://pubmed.ncbi.nlm.nih.gov/17725339 DMMHQRT DI DMMHQRT DMMHQRT DN N-[4'-(trifluoromethyl)-4-biphenylyl]urea DMMHQRT MI TTBGTCW DMMHQRT MN Kinesin spindle messenger RNA (KIF11 mRNA) DMMHQRT MT DTT DMMHQRT MA Inhibitor DMMHQRT RN Novel ATP-competitive kinesin spindle protein inhibitors. J Med Chem. 2007 Oct 4;50(20):4939-52. DMMHQRT RU https://pubmed.ncbi.nlm.nih.gov/17725339 DMMX65T DI DMMX65T DMMX65T DN N-[4-(trifluoromethyl)phenyl]sulfamide DMMX65T MI TTHQPL7 DMMX65T MN Carbonic anhydrase I (CA-I) DMMX65T MT DTT DMMX65T MA Inhibitor DMMX65T RN Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, IX, and XII with N-hydroxy... Bioorg Med Chem Lett. 2005 May 2;15(9):2353-8. DMMX65T RU https://pubmed.ncbi.nlm.nih.gov/15837324 DMMX65T DI DMMX65T DMMX65T DN N-[4-(trifluoromethyl)phenyl]sulfamide DMMX65T MI TTANPDJ DMMX65T MN Carbonic anhydrase II (CA-II) DMMX65T MT DTT DMMX65T MA Inhibitor DMMX65T RN Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, IX, and XII with N-hydroxy... Bioorg Med Chem Lett. 2005 May 2;15(9):2353-8. DMMX65T RU https://pubmed.ncbi.nlm.nih.gov/15837324 DMP5A8K DI DMP5A8K DMP5A8K DN N-[5-(2-Ethyl-phenyl)-furan-2-carbonyl]-guanidine DMP5A8K MI TTGSEFH DMP5A8K MN Sodium/hydrogen exchanger 1 (SLC9A1) DMP5A8K MT DTT DMP5A8K MA Inhibitor DMP5A8K RN (5-Arylfuran-2-ylcarbonyl)guanidines as cardioprotectives through the inhibition of Na+/H+ exchanger isoform-1. J Med Chem. 2005 Apr 21;48(8):2882-91. DMP5A8K RU https://pubmed.ncbi.nlm.nih.gov/15828827 DMZ9V18 DI DMZ9V18 DMZ9V18 DN N-[5-(2-Nitro-phenyl)-furan-2-carbonyl]-guanidine DMZ9V18 MI TTGSEFH DMZ9V18 MN Sodium/hydrogen exchanger 1 (SLC9A1) DMZ9V18 MT DTT DMZ9V18 MA Inhibitor DMZ9V18 RN (5-Arylfuran-2-ylcarbonyl)guanidines as cardioprotectives through the inhibition of Na+/H+ exchanger isoform-1. J Med Chem. 2005 Apr 21;48(8):2882-91. DMZ9V18 RU https://pubmed.ncbi.nlm.nih.gov/15828827 DMSI4PE DI DMSI4PE DMSI4PE DN N-[5-(ethylthio)-1,3,4-thiadiazol-2-yl]sulfamide DMSI4PE MI TTUNARX DMSI4PE MN Carbonic anhydrase (CA) DMSI4PE MT DTT DMSI4PE MA Inhibitor DMSI4PE RN Carbonic anhydrase inhibitors: 2-substituted-1,3,4-thiadiazole-5-sulfamides act as powerful and selective inhibitors of the mitochondrial isozymes ... Bioorg Med Chem Lett. 2008 Dec 15;18(24):6332-5. DMSI4PE RU https://pubmed.ncbi.nlm.nih.gov/18990571 DMSI4PE DI DMSI4PE DMSI4PE DN N-[5-(ethylthio)-1,3,4-thiadiazol-2-yl]sulfamide DMSI4PE MI TTHQPL7 DMSI4PE MN Carbonic anhydrase I (CA-I) DMSI4PE MT DTT DMSI4PE MA Inhibitor DMSI4PE RN Carbonic anhydrase inhibitors: 2-substituted-1,3,4-thiadiazole-5-sulfamides act as powerful and selective inhibitors of the mitochondrial isozymes ... Bioorg Med Chem Lett. 2008 Dec 15;18(24):6332-5. DMSI4PE RU https://pubmed.ncbi.nlm.nih.gov/18990571 DMSI4PE DI DMSI4PE DMSI4PE DN N-[5-(ethylthio)-1,3,4-thiadiazol-2-yl]sulfamide DMSI4PE MI TTANPDJ DMSI4PE MN Carbonic anhydrase II (CA-II) DMSI4PE MT DTT DMSI4PE MA Inhibitor DMSI4PE RN Carbonic anhydrase inhibitors: 2-substituted-1,3,4-thiadiazole-5-sulfamides act as powerful and selective inhibitors of the mitochondrial isozymes ... Bioorg Med Chem Lett. 2008 Dec 15;18(24):6332-5. DMSI4PE RU https://pubmed.ncbi.nlm.nih.gov/18990571 DMSI4PE DI DMSI4PE DMSI4PE DN N-[5-(ethylthio)-1,3,4-thiadiazol-2-yl]sulfamide DMSI4PE MI TTZHA0O DMSI4PE MN Carbonic anhydrase IV (CA-IV) DMSI4PE MT DTT DMSI4PE MA Inhibitor DMSI4PE RN Carbonic anhydrase inhibitors: 2-substituted-1,3,4-thiadiazole-5-sulfamides act as powerful and selective inhibitors of the mitochondrial isozymes ... Bioorg Med Chem Lett. 2008 Dec 15;18(24):6332-5. DMSI4PE RU https://pubmed.ncbi.nlm.nih.gov/18990571 DMH7QOF DI DMH7QOF DMH7QOF DN N-[5-(Formyl-hydroxy-amino)-pentyl]-benzamide DMH7QOF MI TT5ZKDI DMH7QOF MN Histone deacetylase 6 (HDAC6) DMH7QOF MT DTT DMH7QOF MA Inhibitor DMH7QOF RN Design, synthesis, and activity of HDAC inhibitors with a N-formyl hydroxylamine head group. Bioorg Med Chem Lett. 2004 Jan 19;14(2):449-53. DMH7QOF RU https://pubmed.ncbi.nlm.nih.gov/14698179 DMXLJGR DI DMXLJGR DMXLJGR DN N-[5-(methylthio)-1,3,4-thiadiazol-2-yl]sulfamide DMXLJGR MI TTUNARX DMXLJGR MN Carbonic anhydrase (CA) DMXLJGR MT DTT DMXLJGR MA Inhibitor DMXLJGR RN Carbonic anhydrase inhibitors: 2-substituted-1,3,4-thiadiazole-5-sulfamides act as powerful and selective inhibitors of the mitochondrial isozymes ... Bioorg Med Chem Lett. 2008 Dec 15;18(24):6332-5. DMXLJGR RU https://pubmed.ncbi.nlm.nih.gov/18990571 DMXLJGR DI DMXLJGR DMXLJGR DN N-[5-(methylthio)-1,3,4-thiadiazol-2-yl]sulfamide DMXLJGR MI TTHQPL7 DMXLJGR MN Carbonic anhydrase I (CA-I) DMXLJGR MT DTT DMXLJGR MA Inhibitor DMXLJGR RN Carbonic anhydrase inhibitors: 2-substituted-1,3,4-thiadiazole-5-sulfamides act as powerful and selective inhibitors of the mitochondrial isozymes ... Bioorg Med Chem Lett. 2008 Dec 15;18(24):6332-5. DMXLJGR RU https://pubmed.ncbi.nlm.nih.gov/18990571 DMXLJGR DI DMXLJGR DMXLJGR DN N-[5-(methylthio)-1,3,4-thiadiazol-2-yl]sulfamide DMXLJGR MI TTANPDJ DMXLJGR MN Carbonic anhydrase II (CA-II) DMXLJGR MT DTT DMXLJGR MA Inhibitor DMXLJGR RN Carbonic anhydrase inhibitors: 2-substituted-1,3,4-thiadiazole-5-sulfamides act as powerful and selective inhibitors of the mitochondrial isozymes ... Bioorg Med Chem Lett. 2008 Dec 15;18(24):6332-5. DMXLJGR RU https://pubmed.ncbi.nlm.nih.gov/18990571 DMXLJGR DI DMXLJGR DMXLJGR DN N-[5-(methylthio)-1,3,4-thiadiazol-2-yl]sulfamide DMXLJGR MI TTZHA0O DMXLJGR MN Carbonic anhydrase IV (CA-IV) DMXLJGR MT DTT DMXLJGR MA Inhibitor DMXLJGR RN Carbonic anhydrase inhibitors: 2-substituted-1,3,4-thiadiazole-5-sulfamides act as powerful and selective inhibitors of the mitochondrial isozymes ... Bioorg Med Chem Lett. 2008 Dec 15;18(24):6332-5. DMXLJGR RU https://pubmed.ncbi.nlm.nih.gov/18990571 DMVY7RX DI DMVY7RX DMVY7RX DN N-[6-(4-CHLOROPHENYL)-7-(2,4-DICHLOROPHENYL)-2,2-DIMETHYL-3,4-DIHYDRO-2H-PYRANO[2,3-B]PYRIDINE-4-YL]-4,4,4-TRIFLUORO-3-HYDROXYBUTANAMIDE (DIASTEREOMERIC MIX) DMVY7RX MI TT6OEDT DMVY7RX MN Cannabinoid receptor 1 (CB1) DMVY7RX MT DTT DMVY7RX MA Inhibitor DMVY7RX RN Discovery of N-[(4R)-6-(4-chlorophenyl)-7-(2,4-dichlorophenyl)-2,2-dimethyl-3,4-dihydro-2H-pyrano[2,3-b]pyridin-4-yl]-5-methyl-1H-pyrazole-3-carbox... J Med Chem. 2010 May 27;53(10):4028-37. DMVY7RX RU https://pubmed.ncbi.nlm.nih.gov/20423086 DMVY7RX DI DMVY7RX DMVY7RX DN N-[6-(4-CHLOROPHENYL)-7-(2,4-DICHLOROPHENYL)-2,2-DIMETHYL-3,4-DIHYDRO-2H-PYRANO[2,3-B]PYRIDINE-4-YL]-4,4,4-TRIFLUORO-3-HYDROXYBUTANAMIDE (DIASTEREOMERIC MIX) DMVY7RX MI TTMSFAW DMVY7RX MN Cannabinoid receptor 2 (CB2) DMVY7RX MT DTT DMVY7RX MA Inhibitor DMVY7RX RN Discovery of N-[(4R)-6-(4-chlorophenyl)-7-(2,4-dichlorophenyl)-2,2-dimethyl-3,4-dihydro-2H-pyrano[2,3-b]pyridin-4-yl]-5-methyl-1H-pyrazole-3-carbox... J Med Chem. 2010 May 27;53(10):4028-37. DMVY7RX RU https://pubmed.ncbi.nlm.nih.gov/20423086 DMVY7RX DI DMVY7RX DMVY7RX DN N-[6-(4-CHLOROPHENYL)-7-(2,4-DICHLOROPHENYL)-2,2-DIMETHYL-3,4-DIHYDRO-2H-PYRANO[2,3-B]PYRIDINE-4-YL]-4,4,4-TRIFLUORO-3-HYDROXYBUTANAMIDE (DIASTEREOMERIC MIX) DMVY7RX MI TTQ6VDM DMVY7RX MN Voltage-gated potassium channel Kv11.1 (KCNH2) DMVY7RX MT DTT DMVY7RX MA Inhibitor DMVY7RX RN Discovery of N-[(4R)-6-(4-chlorophenyl)-7-(2,4-dichlorophenyl)-2,2-dimethyl-3,4-dihydro-2H-pyrano[2,3-b]pyridin-4-yl]-5-methyl-1H-pyrazole-3-carbox... J Med Chem. 2010 May 27;53(10):4028-37. DMVY7RX RU https://pubmed.ncbi.nlm.nih.gov/20423086 DM6EICU DI DM6EICU DM6EICU DN N-[O-Phosphono-Pyridoxyl]-Isoleucine DM6EICU MI TTF9OQ6 DM6EICU MN Branched-chain-amino-acid transaminase 2 (BCAT2) DM6EICU MT DTT DM6EICU MA Inhibitor DM6EICU RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DM6EICU RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMN493F DI DMN493F DMN493F DN N-[Tosyl-D-Prolinyl]Amino-Ethanethiol DMN493F MI TTU6BFZ DMN493F MN Candida Thymidylate synthase (Candi TMP1) DMN493F MT DTT DMN493F MA Inhibitor DMN493F RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMN493F RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMX4QKU DI DMX4QKU DMX4QKU DN N-{2-[4-(AMINOSULFONYL)PHENYL]ETHYL}ACETAMIDE DMX4QKU MI TTHQPL7 DMX4QKU MN Carbonic anhydrase I (CA-I) DMX4QKU MT DTT DMX4QKU MA Inhibitor DMX4QKU RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DMX4QKU RU https://pubmed.ncbi.nlm.nih.gov/10592235 DMX4QKU DI DMX4QKU DMX4QKU DN N-{2-[4-(AMINOSULFONYL)PHENYL]ETHYL}ACETAMIDE DMX4QKU MI TTANPDJ DMX4QKU MN Carbonic anhydrase II (CA-II) DMX4QKU MT DTT DMX4QKU MA Inhibitor DMX4QKU RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DMX4QKU RU https://pubmed.ncbi.nlm.nih.gov/10592235 DM74KHG DI DM74KHG DM74KHG DN N-{4-[(benzylamino)sulfonyl]-1-naphthyl}benzamide DM74KHG MI TTE836A DM74KHG MN C-C chemokine receptor type 8 (CCR8) DM74KHG MT DTT DM74KHG MA Inhibitor DM74KHG RN Design, synthesis, and evaluation of naphthalene-sulfonamide antagonists of human CCR8. J Med Chem. 2007 Feb 8;50(3):566-84. DM74KHG RU https://pubmed.ncbi.nlm.nih.gov/17266208 DM90U5P DI DM90U5P DM90U5P DN N-{4'-[(trifluoromethyl)sulfonyl]-4-biphenyl}urea DM90U5P MI TTBGTCW DM90U5P MN Kinesin spindle messenger RNA (KIF11 mRNA) DM90U5P MT DTT DM90U5P MA Inhibitor DM90U5P RN Novel ATP-competitive kinesin spindle protein inhibitors. J Med Chem. 2007 Oct 4;50(20):4939-52. DM90U5P RU https://pubmed.ncbi.nlm.nih.gov/17725339 DMEIB69 DI DMEIB69 DMEIB69 DN N-{4'-[(trifluoromethyl)thio]-4-biphenyl}urea DMEIB69 MI TTBGTCW DMEIB69 MN Kinesin spindle messenger RNA (KIF11 mRNA) DMEIB69 MT DTT DMEIB69 MA Inhibitor DMEIB69 RN Novel ATP-competitive kinesin spindle protein inhibitors. J Med Chem. 2007 Oct 4;50(20):4939-52. DMEIB69 RU https://pubmed.ncbi.nlm.nih.gov/17725339 DMO3VLJ DI DMO3VLJ DMO3VLJ DN N-{4-[2-(3-Hydroxyphenyl)ethyl]phenyl}phthalimide DMO3VLJ MI TTECBXN DMO3VLJ MN Oxysterols receptor LXR-alpha (NR1H3) DMO3VLJ MT DTT DMO3VLJ MA Inhibitor DMO3VLJ RN Separation of alpha-glucosidase-inhibitory and liver X receptor-antagonistic activities of phenethylphenyl phthalimide analogs and generation of LX... Bioorg Med Chem. 2009 Jul 15;17(14):5001-14. DMO3VLJ RU https://pubmed.ncbi.nlm.nih.gov/19539483 DMZ4N7Q DI DMZ4N7Q DMZ4N7Q DN N-{4-[2-(3-Methoxyphenyl)ethyl]phenyl}phthalimide DMZ4N7Q MI TTECBXN DMZ4N7Q MN Oxysterols receptor LXR-alpha (NR1H3) DMZ4N7Q MT DTT DMZ4N7Q MA Inhibitor DMZ4N7Q RN Separation of alpha-glucosidase-inhibitory and liver X receptor-antagonistic activities of phenethylphenyl phthalimide analogs and generation of LX... Bioorg Med Chem. 2009 Jul 15;17(14):5001-14. DMZ4N7Q RU https://pubmed.ncbi.nlm.nih.gov/19539483 DMZ4N7Q DI DMZ4N7Q DMZ4N7Q DN N-{4-[2-(3-Methoxyphenyl)ethyl]phenyl}phthalimide DMZ4N7Q MI TTXA6PH DMZ4N7Q MN Oxysterols receptor LXR-beta (NR1H2) DMZ4N7Q MT DTT DMZ4N7Q MA Inhibitor DMZ4N7Q RN Separation of alpha-glucosidase-inhibitory and liver X receptor-antagonistic activities of phenethylphenyl phthalimide analogs and generation of LX... Bioorg Med Chem. 2009 Jul 15;17(14):5001-14. DMZ4N7Q RU https://pubmed.ncbi.nlm.nih.gov/19539483 DMXU5IS DI DMXU5IS DMXU5IS DN N-{4-[2-(4-Hydroxyphenyl)ethyl]phenyl}phthalimide DMXU5IS MI TTECBXN DMXU5IS MN Oxysterols receptor LXR-alpha (NR1H3) DMXU5IS MT DTT DMXU5IS MA Inhibitor DMXU5IS RN Separation of alpha-glucosidase-inhibitory and liver X receptor-antagonistic activities of phenethylphenyl phthalimide analogs and generation of LX... Bioorg Med Chem. 2009 Jul 15;17(14):5001-14. DMXU5IS RU https://pubmed.ncbi.nlm.nih.gov/19539483 DM0S71O DI DM0S71O DM0S71O DN N-{4-[2-(4-Methoxyphenyl)ethyl]phenyl}phthalimide DM0S71O MI TTECBXN DM0S71O MN Oxysterols receptor LXR-alpha (NR1H3) DM0S71O MT DTT DM0S71O MA Inhibitor DM0S71O RN Separation of alpha-glucosidase-inhibitory and liver X receptor-antagonistic activities of phenethylphenyl phthalimide analogs and generation of LX... Bioorg Med Chem. 2009 Jul 15;17(14):5001-14. DM0S71O RU https://pubmed.ncbi.nlm.nih.gov/19539483 DML35GB DI DML35GB DML35GB DN N~3~-(3-PYRIDIN-3-YLBENZYL)PYRIDINE-2,3-DIAMINE DML35GB MI TT8JRS7 DML35GB MN Beta-secretase (BACE) DML35GB MT DTT DML35GB MA Inhibitor DML35GB RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DML35GB RU https://pubmed.ncbi.nlm.nih.gov/10592235 DMOCQ9I DI DMOCQ9I DMOCQ9I DN N~3~-BENZYLPYRIDINE-2,3-DIAMINE DMOCQ9I MI TT8JRS7 DMOCQ9I MN Beta-secretase (BACE) DMOCQ9I MT DTT DMOCQ9I MA Inhibitor DMOCQ9I RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DMOCQ9I RU https://pubmed.ncbi.nlm.nih.gov/10592235 DM6HM5S DI DM6HM5S DM6HM5S DN N1-(2-aminoethyl)ethane-1,2-diamine DM6HM5S MI TTUNARX DM6HM5S MN Carbonic anhydrase (CA) DM6HM5S MT DTT DM6HM5S MA Inhibitor DM6HM5S RN Polyamines inhibit carbonic anhydrases by anchoring to the zinc-coordinated water molecule. J Med Chem. 2010 Aug 12;53(15):5511-22. DM6HM5S RU https://pubmed.ncbi.nlm.nih.gov/20590092 DM6HM5S DI DM6HM5S DM6HM5S DN N1-(2-aminoethyl)ethane-1,2-diamine DM6HM5S MI TT2LVK8 DM6HM5S MN Carbonic anhydrase IX (CA-IX) DM6HM5S MT DTT DM6HM5S MA Inhibitor DM6HM5S RN Polyamines inhibit carbonic anhydrases by anchoring to the zinc-coordinated water molecule. J Med Chem. 2010 Aug 12;53(15):5511-22. DM6HM5S RU https://pubmed.ncbi.nlm.nih.gov/20590092 DM6HM5S DI DM6HM5S DM6HM5S DN N1-(2-aminoethyl)ethane-1,2-diamine DM6HM5S MI TTCFSPE DM6HM5S MN Carbonic anhydrase VI (CA-VI) DM6HM5S MT DTT DM6HM5S MA Inhibitor DM6HM5S RN Polyamines inhibit carbonic anhydrases by anchoring to the zinc-coordinated water molecule. J Med Chem. 2010 Aug 12;53(15):5511-22. DM6HM5S RU https://pubmed.ncbi.nlm.nih.gov/20590092 DM6HM5S DI DM6HM5S DM6HM5S DN N1-(2-aminoethyl)ethane-1,2-diamine DM6HM5S MI TTSYM0R DM6HM5S MN Carbonic anhydrase XII (CA-XII) DM6HM5S MT DTT DM6HM5S MA Inhibitor DM6HM5S RN Polyamines inhibit carbonic anhydrases by anchoring to the zinc-coordinated water molecule. J Med Chem. 2010 Aug 12;53(15):5511-22. DM6HM5S RU https://pubmed.ncbi.nlm.nih.gov/20590092 DM6HM5S DI DM6HM5S DM6HM5S DN N1-(2-aminoethyl)ethane-1,2-diamine DM6HM5S MI TTEYTKG DM6HM5S MN Carbonic anhydrase XIV (CA-XIV) DM6HM5S MT DTT DM6HM5S MA Inhibitor DM6HM5S RN Polyamines inhibit carbonic anhydrases by anchoring to the zinc-coordinated water molecule. J Med Chem. 2010 Aug 12;53(15):5511-22. DM6HM5S RU https://pubmed.ncbi.nlm.nih.gov/20590092 DM6HM5S DI DM6HM5S DM6HM5S DN N1-(2-aminoethyl)ethane-1,2-diamine DM6HM5S MI DEMWO83 DM6HM5S MN Putrescine acetyltransferase (SSAT1) DM6HM5S MT DME DM6HM5S MA Metabolism DM6HM5S RN Mechanistic and structural analysis of human spermidine/spermine N1-acetyltransferase. Biochemistry. 2007 Jun 19;46(24):7187-95. DM6HM5S RU https://www.ncbi.nlm.nih.gov/pubmed/?term=17516632 DM5F04D DI DM5F04D DM5F04D DN N1-(3,3-diphenylpropyl)-N3-hydroxymalonamide DM5F04D MI TTPHMWB DM5F04D MN Aminopeptidase N (ANPEP) DM5F04D MT DTT DM5F04D MA Inhibitor DM5F04D RN Novel selective inhibitors of the zinc plasmodial aminopeptidase PfA-M1 as potential antimalarial agents. J Med Chem. 2007 Mar 22;50(6):1322-34. DM5F04D RU https://pubmed.ncbi.nlm.nih.gov/17326615 DMSRHJA DI DMSRHJA DMSRHJA DN N1-(3-phenoxybenzyl)-N3-hydroxymalonamide DMSRHJA MI TTPHMWB DMSRHJA MN Aminopeptidase N (ANPEP) DMSRHJA MT DTT DMSRHJA MA Inhibitor DMSRHJA RN Novel selective inhibitors of the zinc plasmodial aminopeptidase PfA-M1 as potential antimalarial agents. J Med Chem. 2007 Mar 22;50(6):1322-34. DMSRHJA RU https://pubmed.ncbi.nlm.nih.gov/17326615 DMCH7GO DI DMCH7GO DMCH7GO DN N1-(4-bromophenyl)-N2,N2-dipentylphthalamide DMCH7GO MI TTMSFAW DMCH7GO MN Cannabinoid receptor 2 (CB2) DMCH7GO MT DTT DMCH7GO MA Inhibitor DMCH7GO RN Discovery of novel CB2 receptor ligands by a pharmacophore-based virtual screening workflow. J Med Chem. 2009 Jan 22;52(2):369-78. DMCH7GO RU https://pubmed.ncbi.nlm.nih.gov/19143566 DMJ025O DI DMJ025O DMJ025O DN N1-(4-chlorobenzyl)-2-amino-N3-hydroxymalonamide DMJ025O MI TTPHMWB DMJ025O MN Aminopeptidase N (ANPEP) DMJ025O MT DTT DMJ025O MA Inhibitor DMJ025O RN Novel selective inhibitors of the zinc plasmodial aminopeptidase PfA-M1 as potential antimalarial agents. J Med Chem. 2007 Mar 22;50(6):1322-34. DMJ025O RU https://pubmed.ncbi.nlm.nih.gov/17326615 DMTMDZ4 DI DMTMDZ4 DMTMDZ4 DN N1-(4-chlorobenzyl)-2-benzyl-N3-hydroxymalonamide DMTMDZ4 MI TTPHMWB DMTMDZ4 MN Aminopeptidase N (ANPEP) DMTMDZ4 MT DTT DMTMDZ4 MA Inhibitor DMTMDZ4 RN Novel selective inhibitors of the zinc plasmodial aminopeptidase PfA-M1 as potential antimalarial agents. J Med Chem. 2007 Mar 22;50(6):1322-34. DMTMDZ4 RU https://pubmed.ncbi.nlm.nih.gov/17326615 DMS1P85 DI DMS1P85 DMS1P85 DN N1-(4-fluorobenzyl)-2-benzyl-N3-hydroxymalonamide DMS1P85 MI TTPHMWB DMS1P85 MN Aminopeptidase N (ANPEP) DMS1P85 MT DTT DMS1P85 MA Inhibitor DMS1P85 RN Novel selective inhibitors of the zinc plasmodial aminopeptidase PfA-M1 as potential antimalarial agents. J Med Chem. 2007 Mar 22;50(6):1322-34. DMS1P85 RU https://pubmed.ncbi.nlm.nih.gov/17326615 DMMQXON DI DMMQXON DMMQXON DN N1-(biphenyl-3-yl)-N8-hydroxyoctanediamide DMMQXON MI TT6R7JZ DMMQXON MN Histone deacetylase 1 (HDAC1) DMMQXON MT DTT DMMQXON MA Inhibitor DMMQXON RN Sulfamides as novel histone deacetylase inhibitors. Bioorg Med Chem Lett. 2009 Jan 15;19(2):336-40. DMMQXON RU https://pubmed.ncbi.nlm.nih.gov/19084395 DMMQXON DI DMMQXON DMMQXON DN N1-(biphenyl-3-yl)-N8-hydroxyoctanediamide DMMQXON MI TT5ZKDI DMMQXON MN Histone deacetylase 6 (HDAC6) DMMQXON MT DTT DMMQXON MA Inhibitor DMMQXON RN Sulfamides as novel histone deacetylase inhibitors. Bioorg Med Chem Lett. 2009 Jan 15;19(2):336-40. DMMQXON RU https://pubmed.ncbi.nlm.nih.gov/19084395 DMZA8NC DI DMZA8NC DMZA8NC DN N1-(biphenyl-4-yl)-N8-hydroxyoctanediamide DMZA8NC MI TTBH0VX DMZA8NC MN Histone deacetylase (HDAC) DMZA8NC MT DTT DMZA8NC MA Inhibitor DMZA8NC RN Isoxazole moiety in the linker region of HDAC inhibitors adjacent to the Zn-chelating group: effects on HDAC biology and antiproliferative activity. Bioorg Med Chem Lett. 2009 Jun 1;19(11):3023-6. DMZA8NC RU https://pubmed.ncbi.nlm.nih.gov/19419863 DMZA8NC DI DMZA8NC DMZA8NC DN N1-(biphenyl-4-yl)-N8-hydroxyoctanediamide DMZA8NC MI TT6R7JZ DMZA8NC MN Histone deacetylase 1 (HDAC1) DMZA8NC MT DTT DMZA8NC MA Inhibitor DMZA8NC RN Isoxazole moiety in the linker region of HDAC inhibitors adjacent to the Zn-chelating group: effects on HDAC biology and antiproliferative activity. Bioorg Med Chem Lett. 2009 Jun 1;19(11):3023-6. DMZA8NC RU https://pubmed.ncbi.nlm.nih.gov/19419863 DMZA8NC DI DMZA8NC DMZA8NC DN N1-(biphenyl-4-yl)-N8-hydroxyoctanediamide DMZA8NC MI TT5ZKDI DMZA8NC MN Histone deacetylase 6 (HDAC6) DMZA8NC MT DTT DMZA8NC MA Inhibitor DMZA8NC RN Isoxazole moiety in the linker region of HDAC inhibitors adjacent to the Zn-chelating group: effects on HDAC biology and antiproliferative activity. Bioorg Med Chem Lett. 2009 Jun 1;19(11):3023-6. DMZA8NC RU https://pubmed.ncbi.nlm.nih.gov/19419863 DMYGCSV DI DMYGCSV DMYGCSV DN N1-(naphthalen-1-yl)ethane-1,2-diamine DMYGCSV MI TTUNARX DMYGCSV MN Carbonic anhydrase (CA) DMYGCSV MT DTT DMYGCSV MA Inhibitor DMYGCSV RN Polyamines inhibit carbonic anhydrases by anchoring to the zinc-coordinated water molecule. J Med Chem. 2010 Aug 12;53(15):5511-22. DMYGCSV RU https://pubmed.ncbi.nlm.nih.gov/20590092 DMYGCSV DI DMYGCSV DMYGCSV DN N1-(naphthalen-1-yl)ethane-1,2-diamine DMYGCSV MI TTZHA0O DMYGCSV MN Carbonic anhydrase IV (CA-IV) DMYGCSV MT DTT DMYGCSV MA Inhibitor DMYGCSV RN Polyamines inhibit carbonic anhydrases by anchoring to the zinc-coordinated water molecule. J Med Chem. 2010 Aug 12;53(15):5511-22. DMYGCSV RU https://pubmed.ncbi.nlm.nih.gov/20590092 DMYGCSV DI DMYGCSV DMYGCSV DN N1-(naphthalen-1-yl)ethane-1,2-diamine DMYGCSV MI TT2LVK8 DMYGCSV MN Carbonic anhydrase IX (CA-IX) DMYGCSV MT DTT DMYGCSV MA Inhibitor DMYGCSV RN Polyamines inhibit carbonic anhydrases by anchoring to the zinc-coordinated water molecule. J Med Chem. 2010 Aug 12;53(15):5511-22. DMYGCSV RU https://pubmed.ncbi.nlm.nih.gov/20590092 DMYGCSV DI DMYGCSV DMYGCSV DN N1-(naphthalen-1-yl)ethane-1,2-diamine DMYGCSV MI TTCFSPE DMYGCSV MN Carbonic anhydrase VI (CA-VI) DMYGCSV MT DTT DMYGCSV MA Inhibitor DMYGCSV RN Polyamines inhibit carbonic anhydrases by anchoring to the zinc-coordinated water molecule. J Med Chem. 2010 Aug 12;53(15):5511-22. DMYGCSV RU https://pubmed.ncbi.nlm.nih.gov/20590092 DMYGCSV DI DMYGCSV DMYGCSV DN N1-(naphthalen-1-yl)ethane-1,2-diamine DMYGCSV MI TTSYM0R DMYGCSV MN Carbonic anhydrase XII (CA-XII) DMYGCSV MT DTT DMYGCSV MA Inhibitor DMYGCSV RN Polyamines inhibit carbonic anhydrases by anchoring to the zinc-coordinated water molecule. J Med Chem. 2010 Aug 12;53(15):5511-22. DMYGCSV RU https://pubmed.ncbi.nlm.nih.gov/20590092 DMYGCSV DI DMYGCSV DMYGCSV DN N1-(naphthalen-1-yl)ethane-1,2-diamine DMYGCSV MI TTEYTKG DMYGCSV MN Carbonic anhydrase XIV (CA-XIV) DMYGCSV MT DTT DMYGCSV MA Inhibitor DMYGCSV RN Polyamines inhibit carbonic anhydrases by anchoring to the zinc-coordinated water molecule. J Med Chem. 2010 Aug 12;53(15):5511-22. DMYGCSV RU https://pubmed.ncbi.nlm.nih.gov/20590092 DMM59IS DI DMM59IS DMM59IS DN N1,2-dibenzyl-N3-hydroxymalonamide DMM59IS MI TTPHMWB DMM59IS MN Aminopeptidase N (ANPEP) DMM59IS MT DTT DMM59IS MA Inhibitor DMM59IS RN Novel selective inhibitors of the zinc plasmodial aminopeptidase PfA-M1 as potential antimalarial agents. J Med Chem. 2007 Mar 22;50(6):1322-34. DMM59IS RU https://pubmed.ncbi.nlm.nih.gov/17326615 DM1L89K DI DM1L89K DM1L89K DN N1,2-dibenzyl-N3-hydroxy-N1-phenethylmalonamide DM1L89K MI TTPHMWB DM1L89K MN Aminopeptidase N (ANPEP) DM1L89K MT DTT DM1L89K MA Inhibitor DM1L89K RN Novel selective inhibitors of the zinc plasmodial aminopeptidase PfA-M1 as potential antimalarial agents. J Med Chem. 2007 Mar 22;50(6):1322-34. DM1L89K RU https://pubmed.ncbi.nlm.nih.gov/17326615 DMJ10WH DI DMJ10WH DMJ10WH DN N-1,3,4-thiadiazol-2-ylsulfamide DMJ10WH MI TTHQPL7 DMJ10WH MN Carbonic anhydrase I (CA-I) DMJ10WH MT DTT DMJ10WH MA Inhibitor DMJ10WH RN Carbonic anhydrase inhibitors: 2-substituted-1,3,4-thiadiazole-5-sulfamides act as powerful and selective inhibitors of the mitochondrial isozymes ... Bioorg Med Chem Lett. 2008 Dec 15;18(24):6332-5. DMJ10WH RU https://pubmed.ncbi.nlm.nih.gov/18990571 DMJ10WH DI DMJ10WH DMJ10WH DN N-1,3,4-thiadiazol-2-ylsulfamide DMJ10WH MI TTANPDJ DMJ10WH MN Carbonic anhydrase II (CA-II) DMJ10WH MT DTT DMJ10WH MA Inhibitor DMJ10WH RN Carbonic anhydrase inhibitors: 2-substituted-1,3,4-thiadiazole-5-sulfamides act as powerful and selective inhibitors of the mitochondrial isozymes ... Bioorg Med Chem Lett. 2008 Dec 15;18(24):6332-5. DMJ10WH RU https://pubmed.ncbi.nlm.nih.gov/18990571 DMJ10WH DI DMJ10WH DMJ10WH DN N-1,3,4-thiadiazol-2-ylsulfamide DMJ10WH MI TTZHA0O DMJ10WH MN Carbonic anhydrase IV (CA-IV) DMJ10WH MT DTT DMJ10WH MA Inhibitor DMJ10WH RN Carbonic anhydrase inhibitors: 2-substituted-1,3,4-thiadiazole-5-sulfamides act as powerful and selective inhibitors of the mitochondrial isozymes ... Bioorg Med Chem Lett. 2008 Dec 15;18(24):6332-5. DMJ10WH RU https://pubmed.ncbi.nlm.nih.gov/18990571 DMVIGCJ DI DMVIGCJ DMVIGCJ DN N1,N14-Bis((S-Methyl)Isothioureido)Tetradecane DMVIGCJ MI TTCM4B3 DMVIGCJ MN Nitric-oxide synthase endothelial (NOS3) DMVIGCJ MT DTT DMVIGCJ MA Inhibitor DMVIGCJ RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMVIGCJ RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMSDVGQ DI DMSDVGQ DMSDVGQ DN N1,N2-bis(dihydrocaffeoyl)spermine DMSDVGQ MI TTRTKPV DMSDVGQ MN Trypanosoma Trypanothione reductase (Trypano TPR) DMSDVGQ MT DTT DMSDVGQ MA Inhibitor DMSDVGQ RN The use of natural product scaffolds as leads in the search for trypanothione reductase inhibitors. Bioorg Med Chem. 2008 Jul 15;16(14):6689-95. DMSDVGQ RU https://pubmed.ncbi.nlm.nih.gov/18558492 DMA5Z7P DI DMA5Z7P DMA5Z7P DN N1,N3-bis(3-methoxybenzyl)isophthalamide DMA5Z7P MI TTHY57M DMA5Z7P MN Matrix metalloproteinase-13 (MMP-13) DMA5Z7P MT DTT DMA5Z7P MA Inhibitor DMA5Z7P RN Discovery of (pyridin-4-yl)-2H-tetrazole as a novel scaffold to identify highly selective matrix metalloproteinase-13 inhibitors for the treatment ... Bioorg Med Chem Lett. 2010 Jan 15;20(2):576-80. DMA5Z7P RU https://pubmed.ncbi.nlm.nih.gov/20005097 DMRO7JX DI DMRO7JX DMRO7JX DN N1,N4-bis(5-chloro-2-methylphenyl)succinamide DMRO7JX MI TTEAID7 DMRO7JX MN Trypanosoma Cruzipain (Trypano CYSP) DMRO7JX MT DTT DMRO7JX MA Inhibitor DMRO7JX RN Quantitative analyses of aggregation, autofluorescence, and reactivity artifacts in a screen for inhibitors of a thiol protease. J Med Chem. 2010 Jan 14;53(1):37-51. DMRO7JX RU https://pubmed.ncbi.nlm.nih.gov/19908840 DM4Q86B DI DM4Q86B DM4Q86B DN N1-[4-(Phenylmethoxy)phenyl]-D-aspartamine DM4Q86B MI TTXZEAJ DM4Q86B MN Leukotriene A-4 hydrolase (LTA4H) DM4Q86B MT DTT DM4Q86B MA Inhibitor DM4Q86B RN Synthesis of glutamic acid analogs as potent inhibitors of leukotriene A4 hydrolase. Bioorg Med Chem. 2008 May 1;16(9):4963-83. DM4Q86B RU https://pubmed.ncbi.nlm.nih.gov/18394906 DMK10WX DI DMK10WX DMK10WX DN N1-[4-(Phenylmethoxy)phenyl]-D-glutamine DMK10WX MI TTXZEAJ DMK10WX MN Leukotriene A-4 hydrolase (LTA4H) DMK10WX MT DTT DMK10WX MA Inhibitor DMK10WX RN Synthesis of glutamic acid analogs as potent inhibitors of leukotriene A4 hydrolase. Bioorg Med Chem. 2008 May 1;16(9):4963-83. DMK10WX RU https://pubmed.ncbi.nlm.nih.gov/18394906 DMLEMUX DI DMLEMUX DMLEMUX DN N1-[4-(Phenylmethoxy)phenyl]-L-aspartamine DMLEMUX MI TTXZEAJ DMLEMUX MN Leukotriene A-4 hydrolase (LTA4H) DMLEMUX MT DTT DMLEMUX MA Inhibitor DMLEMUX RN Synthesis of glutamic acid analogs as potent inhibitors of leukotriene A4 hydrolase. Bioorg Med Chem. 2008 May 1;16(9):4963-83. DMLEMUX RU https://pubmed.ncbi.nlm.nih.gov/18394906 DM9XCZS DI DM9XCZS DM9XCZS DN N1-[4-(Phenylmethoxy)phenyl]-L-glutamine DM9XCZS MI TTXZEAJ DM9XCZS MN Leukotriene A-4 hydrolase (LTA4H) DM9XCZS MT DTT DM9XCZS MA Inhibitor DM9XCZS RN Synthesis of glutamic acid analogs as potent inhibitors of leukotriene A4 hydrolase. Bioorg Med Chem. 2008 May 1;16(9):4963-83. DM9XCZS RU https://pubmed.ncbi.nlm.nih.gov/18394906 DMXSFWK DI DMXSFWK DMXSFWK DN N1-benzyl-N3-hydroxy-2-isobutylmalonamide DMXSFWK MI TTPHMWB DMXSFWK MN Aminopeptidase N (ANPEP) DMXSFWK MT DTT DMXSFWK MA Inhibitor DMXSFWK RN A library of novel hydroxamic acids targeting the metallo-protease family: design, parallel synthesis and screening. Bioorg Med Chem. 2007 Jan 1;15(1):63-76. DMXSFWK RU https://pubmed.ncbi.nlm.nih.gov/17070058 DM76CLF DI DM76CLF DM76CLF DN N1-dansyl-spermine DM76CLF MI TTKJEMQ DM76CLF MN Glutamate receptor ionotropic NMDA 2A (NMDAR2A) DM76CLF MT DTT DM76CLF MA Blocker (channel blocker) DM76CLF RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 456). DM76CLF RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=456 DM76CLF DI DM76CLF DM76CLF DN N1-dansyl-spermine DM76CLF MI TTN9D8E DM76CLF MN Glutamate receptor ionotropic NMDA 2B (NMDAR2B) DM76CLF MT DTT DM76CLF MA Blocker (channel blocker) DM76CLF RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 457). DM76CLF RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=457 DM76CLF DI DM76CLF DM76CLF DN N1-dansyl-spermine DM76CLF MI TT1M8OW DM76CLF MN Glutamate receptor ionotropic NMDA 2C (GluN2C) DM76CLF MT DTT DM76CLF MA Blocker (channel blocker) DM76CLF RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 458). DM76CLF RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=458 DM76CLF DI DM76CLF DM76CLF DN N1-dansyl-spermine DM76CLF MI TT5POTG DM76CLF MN Glutamate receptor ionotropic NMDA 2D (GluN2D) DM76CLF MT DTT DM76CLF MA Blocker (channel blocker) DM76CLF RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 459). DM76CLF RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=459 DMXE8CB DI DMXE8CB DMXE8CB DN N1-guanyl-1,7-diaminoheptane DMXE8CB MI TTBO2A9 DMXE8CB MN Deoxyhypusine synthase (DHPS) DMXE8CB MT DTT DMXE8CB MA Inhibitor DMXE8CB RN Effects of N1-guanyl-1,7-diaminoheptane, an inhibitor of deoxyhypusine synthase, on the growth of tumorigenic cell lines in culture. Biochim Biophys Acta. 1996 Jan 10;1310(1):119-26. DMXE8CB RU https://pubmed.ncbi.nlm.nih.gov/9244184 DMF6RVS DI DMF6RVS DMF6RVS DN N1-hydroxy-2-isobutyl-N3-phenethylmalonamide DMF6RVS MI TTPHMWB DMF6RVS MN Aminopeptidase N (ANPEP) DMF6RVS MT DTT DMF6RVS MA Inhibitor DMF6RVS RN A library of novel hydroxamic acids targeting the metallo-protease family: design, parallel synthesis and screening. Bioorg Med Chem. 2007 Jan 1;15(1):63-76. DMF6RVS RU https://pubmed.ncbi.nlm.nih.gov/17070058 DMOZARM DI DMOZARM DMOZARM DN N1-hydroxy-N8-(4-phenylthiazol-2-yl)octanediamide DMOZARM MI TT6R7JZ DMOZARM MN Histone deacetylase 1 (HDAC1) DMOZARM MT DTT DMOZARM MA Inhibitor DMOZARM RN Isoxazole moiety in the linker region of HDAC inhibitors adjacent to the Zn-chelating group: effects on HDAC biology and antiproliferative activity. Bioorg Med Chem Lett. 2009 Jun 1;19(11):3023-6. DMOZARM RU https://pubmed.ncbi.nlm.nih.gov/19419863 DMOZARM DI DMOZARM DMOZARM DN N1-hydroxy-N8-(4-phenylthiazol-2-yl)octanediamide DMOZARM MI TT5ZKDI DMOZARM MN Histone deacetylase 6 (HDAC6) DMOZARM MT DTT DMOZARM MA Inhibitor DMOZARM RN Isoxazole moiety in the linker region of HDAC inhibitors adjacent to the Zn-chelating group: effects on HDAC biology and antiproliferative activity. Bioorg Med Chem Lett. 2009 Jun 1;19(11):3023-6. DMOZARM RU https://pubmed.ncbi.nlm.nih.gov/19419863 DM5LC3D DI DM5LC3D DM5LC3D DN N-1-isopropyl-5-MeOT DM5LC3D MI TTJQOD7 DM5LC3D MN 5-HT 2A receptor (HTR2A) DM5LC3D MT DTT DM5LC3D MA Agonist DM5LC3D RN Species variations in transmembrane region V of the 5-hydroxytryptamine type 2A receptor alter the structure-activity relationship of certain ergolines and tryptamines. Mol Pharmacol. 1994 Feb;45(2):277-86. DM5LC3D RU https://pubmed.ncbi.nlm.nih.gov/8114677 DM25NLH DI DM25NLH DM25NLH DN N-1-isopropyltryptamine DM25NLH MI TTJQOD7 DM25NLH MN 5-HT 2A receptor (HTR2A) DM25NLH MT DTT DM25NLH MA Agonist DM25NLH RN Species variations in transmembrane region V of the 5-hydroxytryptamine type 2A receptor alter the structure-activity relationship of certain ergolines and tryptamines. Mol Pharmacol. 1994 Feb;45(2):277-86. DM25NLH RU https://pubmed.ncbi.nlm.nih.gov/8114677 DMGJEH9 DI DMGJEH9 DMGJEH9 DN N2-(3-trifluoromethylphenyl)guanine DMGJEH9 MI TTP3QRF DMGJEH9 MN Thymidine kinase 1 (TK1) DMGJEH9 MT DTT DMGJEH9 MA Inhibitor DMGJEH9 RN Sensitivity of monkey B virus (Cercopithecine herpesvirus 1) to antiviral drugs: role of thymidine kinase in antiviral activities of substrate anal... Antimicrob Agents Chemother. 2007 Jun;51(6):2028-34. DMGJEH9 RU https://pubmed.ncbi.nlm.nih.gov/17438061 DMOZ1IY DI DMOZ1IY DMOZ1IY DN N2-[4-(benzyloxy)benzyl]glycinamide DMOZ1IY MI TT3WG5C DMOZ1IY MN Monoamine oxidase type A (MAO-A) DMOZ1IY MT DTT DMOZ1IY MA Inhibitor DMOZ1IY RN Solid-phase synthesis and insights into structure-activity relationships of safinamide analogues as potent and selective inhibitors of type B monoa... J Med Chem. 2007 Oct 4;50(20):4909-16. DMOZ1IY RU https://pubmed.ncbi.nlm.nih.gov/17824599 DMOZ1IY DI DMOZ1IY DMOZ1IY DN N2-[4-(benzyloxy)benzyl]glycinamide DMOZ1IY MI TTGP7BY DMOZ1IY MN Monoamine oxidase type B (MAO-B) DMOZ1IY MT DTT DMOZ1IY MA Inhibitor DMOZ1IY RN Solid-phase synthesis and insights into structure-activity relationships of safinamide analogues as potent and selective inhibitors of type B monoa... J Med Chem. 2007 Oct 4;50(20):4909-16. DMOZ1IY RU https://pubmed.ncbi.nlm.nih.gov/17824599 DMHJ2IP DI DMHJ2IP DMHJ2IP DN N2-{4-[(3-chlorobenzyl)oxy]benzyl}glycinamide DMHJ2IP MI TTGP7BY DMHJ2IP MN Monoamine oxidase type B (MAO-B) DMHJ2IP MT DTT DMHJ2IP MA Inhibitor DMHJ2IP RN Solid-phase synthesis and insights into structure-activity relationships of safinamide analogues as potent and selective inhibitors of type B monoa... J Med Chem. 2007 Oct 4;50(20):4909-16. DMHJ2IP RU https://pubmed.ncbi.nlm.nih.gov/17824599 DMEWP9L DI DMEWP9L DMEWP9L DN N2-{4-[(3-fluorobenzyl)oxy]benzyl}glycinamide DMEWP9L MI TT3WG5C DMEWP9L MN Monoamine oxidase type A (MAO-A) DMEWP9L MT DTT DMEWP9L MA Inhibitor DMEWP9L RN Solid-phase synthesis and insights into structure-activity relationships of safinamide analogues as potent and selective inhibitors of type B monoa... J Med Chem. 2007 Oct 4;50(20):4909-16. DMEWP9L RU https://pubmed.ncbi.nlm.nih.gov/17824599 DMEWP9L DI DMEWP9L DMEWP9L DN N2-{4-[(3-fluorobenzyl)oxy]benzyl}glycinamide DMEWP9L MI TTGP7BY DMEWP9L MN Monoamine oxidase type B (MAO-B) DMEWP9L MT DTT DMEWP9L MA Inhibitor DMEWP9L RN Solid-phase synthesis and insights into structure-activity relationships of safinamide analogues as potent and selective inhibitors of type B monoa... J Med Chem. 2007 Oct 4;50(20):4909-16. DMEWP9L RU https://pubmed.ncbi.nlm.nih.gov/17824599 DMLPJGX DI DMLPJGX DMLPJGX DN N2-{4-[(4-chlorobenzyl)oxy]benzyl}glycinamide DMLPJGX MI TT3WG5C DMLPJGX MN Monoamine oxidase type A (MAO-A) DMLPJGX MT DTT DMLPJGX MA Inhibitor DMLPJGX RN Solid-phase synthesis and insights into structure-activity relationships of safinamide analogues as potent and selective inhibitors of type B monoa... J Med Chem. 2007 Oct 4;50(20):4909-16. DMLPJGX RU https://pubmed.ncbi.nlm.nih.gov/17824599 DMLPJGX DI DMLPJGX DMLPJGX DN N2-{4-[(4-chlorobenzyl)oxy]benzyl}glycinamide DMLPJGX MI TTGP7BY DMLPJGX MN Monoamine oxidase type B (MAO-B) DMLPJGX MT DTT DMLPJGX MA Inhibitor DMLPJGX RN Solid-phase synthesis and insights into structure-activity relationships of safinamide analogues as potent and selective inhibitors of type B monoa... J Med Chem. 2007 Oct 4;50(20):4909-16. DMLPJGX RU https://pubmed.ncbi.nlm.nih.gov/17824599 DMAVB0G DI DMAVB0G DMAVB0G DN N2-{4-[(4-nitrobenzyl)oxy]benzyl}glycinamide DMAVB0G MI TTGP7BY DMAVB0G MN Monoamine oxidase type B (MAO-B) DMAVB0G MT DTT DMAVB0G MA Inhibitor DMAVB0G RN Solid-phase synthesis and insights into structure-activity relationships of safinamide analogues as potent and selective inhibitors of type B monoa... J Med Chem. 2007 Oct 4;50(20):4909-16. DMAVB0G RU https://pubmed.ncbi.nlm.nih.gov/17824599 DM3WTDL DI DM3WTDL DM3WTDL DN N-2-phenylethyl-1H-pyrrole-2-carboxamide DM3WTDL MI TT3WG5C DM3WTDL MN Monoamine oxidase type A (MAO-A) DM3WTDL MT DTT DM3WTDL MA Inhibitor DM3WTDL RN New pyrrole inhibitors of monoamine oxidase: synthesis, biological evaluation, and structural determinants of MAO-A and MAO-B selectivity. J Med Chem. 2007 Mar 8;50(5):922-31. DM3WTDL RU https://pubmed.ncbi.nlm.nih.gov/17256833 DMLK0J8 DI DMLK0J8 DMLK0J8 DN N-2-Thiophen-2-Yl-Acetamide Boronic Acid DMLK0J8 MI TTHI19T DMLK0J8 MN Staphylococcus Beta-lactamase (Stap-coc blaZ) DMLK0J8 MT DTT DMLK0J8 MA Inhibitor DMLK0J8 RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMLK0J8 RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMFRD09 DI DMFRD09 DMFRD09 DN N-3-(4-bromophenyl)propyl imidazole DMFRD09 MI TTRA5BZ DMFRD09 MN Steroid 17-alpha-monooxygenase (S17AH) DMFRD09 MT DTT DMFRD09 MA Inhibitor DMFRD09 RN Synthesis, biochemical evaluation and rationalisation of the inhibitory activity of a range of 4-substituted phenyl alkyl imidazole-based inhibitor... Bioorg Med Chem Lett. 2006 Sep 15;16(18):4752-6. DMFRD09 RU https://pubmed.ncbi.nlm.nih.gov/16870430 DMWZTKD DI DMWZTKD DMWZTKD DN N-3'-ethylaplysinopsin DMWZTKD MI TTJQOD7 DMWZTKD MN 5-HT 2A receptor (HTR2A) DMWZTKD MT DTT DMWZTKD MA Inhibitor DMWZTKD RN New antiinfective and human 5-HT2 receptor binding natural and semisynthetic compounds from the Jamaican sponge Smenospongia aurea. J Nat Prod. 2002 Apr;65(4):476-80. DMWZTKD RU https://pubmed.ncbi.nlm.nih.gov/11975483 DMWZTKD DI DMWZTKD DMWZTKD DN N-3'-ethylaplysinopsin DMWZTKD MI TTWJBZ5 DMWZTKD MN 5-HT 2C receptor (HTR2C) DMWZTKD MT DTT DMWZTKD MA Inhibitor DMWZTKD RN New antiinfective and human 5-HT2 receptor binding natural and semisynthetic compounds from the Jamaican sponge Smenospongia aurea. J Nat Prod. 2002 Apr;65(4):476-80. DMWZTKD RU https://pubmed.ncbi.nlm.nih.gov/11975483 DMQEGJU DI DMQEGJU DMQEGJU DN N3-GHQMFYYPra-NH2 DMQEGJU MI TT1VAUK DMQEGJU MN VEGFR1 messenger RNA (VEGFR1 mRNA) DMQEGJU MT DTT DMQEGJU MA Inhibitor DMQEGJU RN On-resin cyclization of peptide ligands of the Vascular Endothelial Growth Factor Receptor 1 by copper(I)-catalyzed 1,3-dipolar azide-alkyne cycloa... Bioorg Med Chem Lett. 2007 Oct 15;17(20):5590-4. DMQEGJU RU https://pubmed.ncbi.nlm.nih.gov/17826090 DM561Z7 DI DM561Z7 DM561Z7 DN N4-(3-chlorophenyl)quinazoline-4,6-diamine DM561Z7 MI TTGKNB4 DM561Z7 MN Epidermal growth factor receptor (EGFR) DM561Z7 MT DTT DM561Z7 MA Inhibitor DM561Z7 RN Novel nitrogen mustard-armed combi-molecules for the selective targeting of epidermal growth factor receptor overexperessing solid tumors: discover... J Med Chem. 2007 May 31;50(11):2605-8. DM561Z7 RU https://pubmed.ncbi.nlm.nih.gov/17472358 DMDRYJ7 DI DMDRYJ7 DMDRYJ7 DN N4-(3-methylphenyl)-4,6-quinazolinediamine DMDRYJ7 MI TTGKNB4 DMDRYJ7 MN Epidermal growth factor receptor (EGFR) DMDRYJ7 MT DTT DMDRYJ7 MA Inhibitor DMDRYJ7 RN The combi-targeting concept: synthesis of stable nitrosoureas designed to inhibit the epidermal growth factor receptor (EGFR). J Med Chem. 2006 Jun 15;49(12):3544-52. DMDRYJ7 RU https://pubmed.ncbi.nlm.nih.gov/16759097 DMARZHU DI DMARZHU DMARZHU DN N4-(4-chlorobenzyl)-2,4-diaminobutanoylpiperidine DMARZHU MI TTDIGC1 DMARZHU MN Dipeptidyl peptidase 4 (DPP-4) DMARZHU MT DTT DMARZHU MA Inhibitor DMARZHU RN Synthesis and dipeptidyl peptidase inhibition of N-(4-substituted-2,4-diaminobutanoyl)piperidines. Bioorg Med Chem Lett. 2006 Sep 15;16(18):4777-9. DMARZHU RU https://pubmed.ncbi.nlm.nih.gov/16844373 DMARZHU DI DMARZHU DMARZHU DN N4-(4-chlorobenzyl)-2,4-diaminobutanoylpiperidine DMARZHU MI TTOYT5L DMARZHU MN Dipeptidyl-peptidase 7 (DPP7) DMARZHU MT DTT DMARZHU MA Inhibitor DMARZHU RN Dipeptidyl peptidase II and leukocyte cell death. Biochem Pharmacol. 2006 Jun 28;72(1):70-9. DMARZHU RU https://pubmed.ncbi.nlm.nih.gov/16725115 DMYPZMO DI DMYPZMO DMYPZMO DN N4-(N,N-diphenylcarbamoyl)-aminoguanidine DMYPZMO MI TT6L509 DMYPZMO MN Coagulation factor IIa (F2) DMYPZMO MT DTT DMYPZMO MA Inhibitor DMYPZMO RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DMYPZMO RU https://pubmed.ncbi.nlm.nih.gov/10592235 DMCR13E DI DMCR13E DMCR13E DN N4,N6-dibenzylpyrimidine-4,6-dicarboxamide DMCR13E MI TTHY57M DMCR13E MN Matrix metalloproteinase-13 (MMP-13) DMCR13E MT DTT DMCR13E MA Inhibitor DMCR13E RN Calculation of binding free energies for non-zinc chelating pyrimidine dicarboxamide inhibitors with MMP-13. Bioorg Med Chem Lett. 2009 Jan 1;19(1):47-50. DMCR13E RU https://pubmed.ncbi.nlm.nih.gov/19042129 DMV7ORJ DI DMV7ORJ DMV7ORJ DN N4-[4-(Phenylmethoxy)phenyl]-L-aspartamine DMV7ORJ MI TTXZEAJ DMV7ORJ MN Leukotriene A-4 hydrolase (LTA4H) DMV7ORJ MT DTT DMV7ORJ MA Inhibitor DMV7ORJ RN Synthesis of glutamic acid analogs as potent inhibitors of leukotriene A4 hydrolase. Bioorg Med Chem. 2008 May 1;16(9):4963-83. DMV7ORJ RU https://pubmed.ncbi.nlm.nih.gov/18394906 DM1N73J DI DM1N73J DM1N73J DN N4-Butyl-2-cinnamamido-N1-hydroxysuccinamide DM1N73J MI TTPHMWB DM1N73J MN Aminopeptidase N (ANPEP) DM1N73J MT DTT DM1N73J MA Inhibitor DM1N73J RN Design, synthesis, and preliminary studies of the activity of novel derivatives of N-cinnamoyl-L-aspartic acid as inhibitors of aminopeptidase N/CD13. Bioorg Med Chem. 2009 Oct 15;17(20):7398-404. DM1N73J RU https://pubmed.ncbi.nlm.nih.gov/19782572 DM7KX2V DI DM7KX2V DM7KX2V DN N4-phenylethoxycytidine-5'-triphosphate DM7KX2V MI TT24DGP DM7KX2V MN P2Y purinoceptor 4 (P2RY4) DM7KX2V MT DTT DM7KX2V MA Agonist DM7KX2V RN Pyrimidine nucleotides with 4-alkyloxyimino and terminal tetraphosphate delta-ester modifications as selective agonists of the P2Y(4) receptor. J Med Chem. 2011 Jun 23;54(12):4018-33. DM7KX2V RU https://pubmed.ncbi.nlm.nih.gov/21528910 DMY3O6N DI DMY3O6N DMY3O6N DN N5-(1-Imino-3-Butenyl)-L-Ornithine DMY3O6N MI TTZUFI5 DMY3O6N MN Nitric-oxide synthase brain (NOS1) DMY3O6N MT DTT DMY3O6N MA Inhibitor DMY3O6N RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMY3O6N RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMB62OI DI DMB62OI DMB62OI DN N5-(1-iminobut-3-enyl)-L-ornithine DMB62OI MI TTZUFI5 DMB62OI MN Nitric-oxide synthase brain (NOS1) DMB62OI MT DTT DMB62OI MA Inhibitor DMB62OI RN Structure-activity relationship of novel and known inhibitors of human dimethylarginine dimethylaminohydrolase-1: alkenyl-amidines as new leads. Bioorg Med Chem. 2008 Dec 15;16(24):10205-9. DMB62OI RU https://pubmed.ncbi.nlm.nih.gov/19013076 DMB62OI DI DMB62OI DMB62OI DN N5-(1-iminobut-3-enyl)-L-ornithine DMB62OI MI TTCM4B3 DMB62OI MN Nitric-oxide synthase endothelial (NOS3) DMB62OI MT DTT DMB62OI MA Inhibitor DMB62OI RN Structure-activity relationship of novel and known inhibitors of human dimethylarginine dimethylaminohydrolase-1: alkenyl-amidines as new leads. Bioorg Med Chem. 2008 Dec 15;16(24):10205-9. DMB62OI RU https://pubmed.ncbi.nlm.nih.gov/19013076 DMB62OI DI DMB62OI DMB62OI DN N5-(1-iminobut-3-enyl)-L-ornithine DMB62OI MI TTF10I9 DMB62OI MN Nitric-oxide synthase inducible (NOS2) DMB62OI MT DTT DMB62OI MA Inhibitor DMB62OI RN Structure-activity relationship of novel and known inhibitors of human dimethylarginine dimethylaminohydrolase-1: alkenyl-amidines as new leads. Bioorg Med Chem. 2008 Dec 15;16(24):10205-9. DMB62OI RU https://pubmed.ncbi.nlm.nih.gov/19013076 DMT893N DI DMT893N DMT893N DN N5-(1-iminobutyl)-L-ornithine DMT893N MI TTZUFI5 DMT893N MN Nitric-oxide synthase brain (NOS1) DMT893N MT DTT DMT893N MA Inhibitor DMT893N RN Structure-activity relationship of novel and known inhibitors of human dimethylarginine dimethylaminohydrolase-1: alkenyl-amidines as new leads. Bioorg Med Chem. 2008 Dec 15;16(24):10205-9. DMT893N RU https://pubmed.ncbi.nlm.nih.gov/19013076 DMT893N DI DMT893N DMT893N DN N5-(1-iminobutyl)-L-ornithine DMT893N MI TTCM4B3 DMT893N MN Nitric-oxide synthase endothelial (NOS3) DMT893N MT DTT DMT893N MA Inhibitor DMT893N RN Structure-activity relationship of novel and known inhibitors of human dimethylarginine dimethylaminohydrolase-1: alkenyl-amidines as new leads. Bioorg Med Chem. 2008 Dec 15;16(24):10205-9. DMT893N RU https://pubmed.ncbi.nlm.nih.gov/19013076 DMT893N DI DMT893N DMT893N DN N5-(1-iminobutyl)-L-ornithine DMT893N MI TTF10I9 DMT893N MN Nitric-oxide synthase inducible (NOS2) DMT893N MT DTT DMT893N MA Inhibitor DMT893N RN Structure-activity relationship of novel and known inhibitors of human dimethylarginine dimethylaminohydrolase-1: alkenyl-amidines as new leads. Bioorg Med Chem. 2008 Dec 15;16(24):10205-9. DMT893N RU https://pubmed.ncbi.nlm.nih.gov/19013076 DM0TS21 DI DM0TS21 DM0TS21 DN N5-(1-iminopent-3-enyl)-L-ornithine DM0TS21 MI TTZUFI5 DM0TS21 MN Nitric-oxide synthase brain (NOS1) DM0TS21 MT DTT DM0TS21 MA Inhibitor DM0TS21 RN Structure-activity relationship of novel and known inhibitors of human dimethylarginine dimethylaminohydrolase-1: alkenyl-amidines as new leads. Bioorg Med Chem. 2008 Dec 15;16(24):10205-9. DM0TS21 RU https://pubmed.ncbi.nlm.nih.gov/19013076 DM05O7J DI DM05O7J DM05O7J DN N5-(1-iminopropyl)-L-ornithine DM05O7J MI TTZUFI5 DM05O7J MN Nitric-oxide synthase brain (NOS1) DM05O7J MT DTT DM05O7J MA Inhibitor DM05O7J RN Structure-activity relationship of novel and known inhibitors of human dimethylarginine dimethylaminohydrolase-1: alkenyl-amidines as new leads. Bioorg Med Chem. 2008 Dec 15;16(24):10205-9. DM05O7J RU https://pubmed.ncbi.nlm.nih.gov/19013076 DM05O7J DI DM05O7J DM05O7J DN N5-(1-iminopropyl)-L-ornithine DM05O7J MI TTCM4B3 DM05O7J MN Nitric-oxide synthase endothelial (NOS3) DM05O7J MT DTT DM05O7J MA Inhibitor DM05O7J RN Structure-activity relationship of novel and known inhibitors of human dimethylarginine dimethylaminohydrolase-1: alkenyl-amidines as new leads. Bioorg Med Chem. 2008 Dec 15;16(24):10205-9. DM05O7J RU https://pubmed.ncbi.nlm.nih.gov/19013076 DM05O7J DI DM05O7J DM05O7J DN N5-(1-iminopropyl)-L-ornithine DM05O7J MI TTF10I9 DM05O7J MN Nitric-oxide synthase inducible (NOS2) DM05O7J MT DTT DM05O7J MA Inhibitor DM05O7J RN Structure-activity relationship of novel and known inhibitors of human dimethylarginine dimethylaminohydrolase-1: alkenyl-amidines as new leads. Bioorg Med Chem. 2008 Dec 15;16(24):10205-9. DM05O7J RU https://pubmed.ncbi.nlm.nih.gov/19013076 DMNVK6T DI DMNVK6T DMNVK6T DN N5-(4-Phenoxyphenyl)-L-glutamine DMNVK6T MI TTXZEAJ DMNVK6T MN Leukotriene A-4 hydrolase (LTA4H) DMNVK6T MT DTT DMNVK6T MA Inhibitor DMNVK6T RN Synthesis of glutamic acid analogs as potent inhibitors of leukotriene A4 hydrolase. Bioorg Med Chem. 2008 May 1;16(9):4963-83. DMNVK6T RU https://pubmed.ncbi.nlm.nih.gov/18394906 DMXUODT DI DMXUODT DMXUODT DN N5-[(4-Phenoxy)-3-pyridyl]-L-glutamamide DMXUODT MI TTXZEAJ DMXUODT MN Leukotriene A-4 hydrolase (LTA4H) DMXUODT MT DTT DMXUODT MA Inhibitor DMXUODT RN Synthesis of glutamic acid analogs as potent inhibitors of leukotriene A4 hydrolase. Bioorg Med Chem. 2008 May 1;16(9):4963-83. DMXUODT RU https://pubmed.ncbi.nlm.nih.gov/18394906 DMJT4UR DI DMJT4UR DMJT4UR DN N5-[4-(1H-pyrrol-1-yl)phenyl]-L-glutamamide DMJT4UR MI TTXZEAJ DMJT4UR MN Leukotriene A-4 hydrolase (LTA4H) DMJT4UR MT DTT DMJT4UR MA Inhibitor DMJT4UR RN Synthesis of glutamic acid analogs as potent inhibitors of leukotriene A4 hydrolase. Bioorg Med Chem. 2008 May 1;16(9):4963-83. DMJT4UR RU https://pubmed.ncbi.nlm.nih.gov/18394906 DMR2C94 DI DMR2C94 DMR2C94 DN N5-[4-(2-methylphenoxy)phenyl]-L-glutamamide DMR2C94 MI TTXZEAJ DMR2C94 MN Leukotriene A-4 hydrolase (LTA4H) DMR2C94 MT DTT DMR2C94 MA Inhibitor DMR2C94 RN Synthesis of glutamic acid analogs as potent inhibitors of leukotriene A4 hydrolase. Bioorg Med Chem. 2008 May 1;16(9):4963-83. DMR2C94 RU https://pubmed.ncbi.nlm.nih.gov/18394906 DM97H52 DI DM97H52 DM97H52 DN N5-[4-(2-Oxo-3-phenylpropoxy)phenyl]-L-glutamine DM97H52 MI TTXZEAJ DM97H52 MN Leukotriene A-4 hydrolase (LTA4H) DM97H52 MT DTT DM97H52 MA Inhibitor DM97H52 RN Synthesis of glutamic acid analogs as potent inhibitors of leukotriene A4 hydrolase. Bioorg Med Chem. 2008 May 1;16(9):4963-83. DM97H52 RU https://pubmed.ncbi.nlm.nih.gov/18394906 DMR1XJN DI DMR1XJN DMR1XJN DN N5-[4-(2-phenylethoxy)phenyl]-L-glutamine DMR1XJN MI TTXZEAJ DMR1XJN MN Leukotriene A-4 hydrolase (LTA4H) DMR1XJN MT DTT DMR1XJN MA Inhibitor DMR1XJN RN Synthesis of glutamic acid analogs as potent inhibitors of leukotriene A4 hydrolase. Bioorg Med Chem. 2008 May 1;16(9):4963-83. DMR1XJN RU https://pubmed.ncbi.nlm.nih.gov/18394906 DMTO8KS DI DMTO8KS DMTO8KS DN N5-[4-(3-methylphenoxy)phenyl]-L-glutamamide DMTO8KS MI TTXZEAJ DMTO8KS MN Leukotriene A-4 hydrolase (LTA4H) DMTO8KS MT DTT DMTO8KS MA Inhibitor DMTO8KS RN Synthesis of glutamic acid analogs as potent inhibitors of leukotriene A4 hydrolase. Bioorg Med Chem. 2008 May 1;16(9):4963-83. DMTO8KS RU https://pubmed.ncbi.nlm.nih.gov/18394906 DMINK9Q DI DMINK9Q DMINK9Q DN N5-[4-(3-Phenylpropoxy)phenyl]-L-glutamine DMINK9Q MI TTXZEAJ DMINK9Q MN Leukotriene A-4 hydrolase (LTA4H) DMINK9Q MT DTT DMINK9Q MA Inhibitor DMINK9Q RN Synthesis of glutamic acid analogs as potent inhibitors of leukotriene A4 hydrolase. Bioorg Med Chem. 2008 May 1;16(9):4963-83. DMINK9Q RU https://pubmed.ncbi.nlm.nih.gov/18394906 DM6PXMJ DI DM6PXMJ DM6PXMJ DN N5-[4-(4-(3-Furyl)phenoxy)phenyl]-L-glutamamide DM6PXMJ MI TTXZEAJ DM6PXMJ MN Leukotriene A-4 hydrolase (LTA4H) DM6PXMJ MT DTT DM6PXMJ MA Inhibitor DM6PXMJ RN Synthesis of glutamic acid analogs as potent inhibitors of leukotriene A4 hydrolase. Bioorg Med Chem. 2008 May 1;16(9):4963-83. DM6PXMJ RU https://pubmed.ncbi.nlm.nih.gov/18394906 DMMV1CB DI DMMV1CB DMMV1CB DN N5-[4-(4-methylphenoxy)phenyl]-L-glutamamide DMMV1CB MI TTXZEAJ DMMV1CB MN Leukotriene A-4 hydrolase (LTA4H) DMMV1CB MT DTT DMMV1CB MA Inhibitor DMMV1CB RN Synthesis of glutamic acid analogs as potent inhibitors of leukotriene A4 hydrolase. Bioorg Med Chem. 2008 May 1;16(9):4963-83. DMMV1CB RU https://pubmed.ncbi.nlm.nih.gov/18394906 DMH8VYM DI DMH8VYM DMH8VYM DN N5-[4-(N-Phenylamino)phenyl]-L-glutamine DMH8VYM MI TTXZEAJ DMH8VYM MN Leukotriene A-4 hydrolase (LTA4H) DMH8VYM MT DTT DMH8VYM MA Inhibitor DMH8VYM RN Synthesis of glutamic acid analogs as potent inhibitors of leukotriene A4 hydrolase. Bioorg Med Chem. 2008 May 1;16(9):4963-83. DMH8VYM RU https://pubmed.ncbi.nlm.nih.gov/18394906 DMUVP5L DI DMUVP5L DMUVP5L DN N5-[4-(Phenylmethoxy)phenyl]-D-glutamine DMUVP5L MI TTXZEAJ DMUVP5L MN Leukotriene A-4 hydrolase (LTA4H) DMUVP5L MT DTT DMUVP5L MA Inhibitor DMUVP5L RN Synthesis of glutamic acid analogs as potent inhibitors of leukotriene A4 hydrolase. Bioorg Med Chem. 2008 May 1;16(9):4963-83. DMUVP5L RU https://pubmed.ncbi.nlm.nih.gov/18394906 DMMYIJ0 DI DMMYIJ0 DMMYIJ0 DN N5-[4-(Phenylmethoxy)phenyl]-L-glutamamide DMMYIJ0 MI TTXZEAJ DMMYIJ0 MN Leukotriene A-4 hydrolase (LTA4H) DMMYIJ0 MT DTT DMMYIJ0 MA Inhibitor DMMYIJ0 RN Synthesis of glutamic acid analogs as potent inhibitors of leukotriene A4 hydrolase. Bioorg Med Chem. 2008 May 1;16(9):4963-83. DMMYIJ0 RU https://pubmed.ncbi.nlm.nih.gov/18394906 DMCG26A DI DMCG26A DMCG26A DN N5-[4-(Phenylmethoxy)phenyl]-L-glutamine DMCG26A MI TTXZEAJ DMCG26A MN Leukotriene A-4 hydrolase (LTA4H) DMCG26A MT DTT DMCG26A MA Inhibitor DMCG26A RN Synthesis of glutamic acid analogs as potent inhibitors of leukotriene A4 hydrolase. Bioorg Med Chem. 2008 May 1;16(9):4963-83. DMCG26A RU https://pubmed.ncbi.nlm.nih.gov/18394906 DMH6O4G DI DMH6O4G DMH6O4G DN N5-[4-Benzylphenyl]-L-glutamamide DMH6O4G MI TTXZEAJ DMH6O4G MN Leukotriene A-4 hydrolase (LTA4H) DMH6O4G MT DTT DMH6O4G MA Inhibitor DMH6O4G RN Synthesis of glutamic acid analogs as potent inhibitors of leukotriene A4 hydrolase. Bioorg Med Chem. 2008 May 1;16(9):4963-83. DMH6O4G RU https://pubmed.ncbi.nlm.nih.gov/18394906 DML0R9M DI DML0R9M DML0R9M DN N5-methylfolate DML0R9M MI DTFI42L DML0R9M MN Multidrug resistance-associated protein 2 (ABCC2) DML0R9M MT DTP DML0R9M MA Substrate DML0R9M RN Human intestinal transporter database: QSAR modeling and virtual profiling of drug uptake, efflux and interactions. Pharm Res. 2013 Apr;30(4):996-1007. DML0R9M RU https://doi.org/10.1007/s11095-012-0935-x DMXSZ1A DI DMXSZ1A DMXSZ1A DN N6 benzyl-cAMP DMXSZ1A MI TTYVI76 DMXSZ1A MN Fungal Protein kinase A (Fung ypkA) DMXSZ1A MT DTT DMXSZ1A MA Activator DMXSZ1A RN cAMP analog mapping of Epac1 and cAMP kinase. Discriminating analogs demonstrate that Epac and cAMP kinase act synergistically to promote PC-12 cel... J Biol Chem. 2003 Sep 12;278(37):35394-402. DMXSZ1A RU https://pubmed.ncbi.nlm.nih.gov/12819211 DM30KXV DI DM30KXV DM30KXV DN N6-((+/-)-endo-norborn-2-yl)adenosine DM30KXV MI TTK25J1 DM30KXV MN Adenosine A1 receptor (ADORA1) DM30KXV MT DTT DM30KXV MA Inhibitor DM30KXV RN N6-Cycloalkyl- and N6-bicycloalkyl-C5'(C2')-modified adenosine derivatives as high-affinity and selective agonists at the human A1 adenosine recept... J Med Chem. 2009 Apr 23;52(8):2393-406. DM30KXV RU https://pubmed.ncbi.nlm.nih.gov/19317449 DM30KXV DI DM30KXV DM30KXV DN N6-((+/-)-endo-norborn-2-yl)adenosine DM30KXV MI TTM2AOE DM30KXV MN Adenosine A2a receptor (ADORA2A) DM30KXV MT DTT DM30KXV MA Inhibitor DM30KXV RN N6-Cycloalkyl- and N6-bicycloalkyl-C5'(C2')-modified adenosine derivatives as high-affinity and selective agonists at the human A1 adenosine recept... J Med Chem. 2009 Apr 23;52(8):2393-406. DM30KXV RU https://pubmed.ncbi.nlm.nih.gov/19317449 DM30KXV DI DM30KXV DM30KXV DN N6-((+/-)-endo-norborn-2-yl)adenosine DM30KXV MI TTNE7KG DM30KXV MN Adenosine A2b receptor (ADORA2B) DM30KXV MT DTT DM30KXV MA Inhibitor DM30KXV RN N6-Cycloalkyl- and N6-bicycloalkyl-C5'(C2')-modified adenosine derivatives as high-affinity and selective agonists at the human A1 adenosine recept... J Med Chem. 2009 Apr 23;52(8):2393-406. DM30KXV RU https://pubmed.ncbi.nlm.nih.gov/19317449 DM30KXV DI DM30KXV DM30KXV DN N6-((+/-)-endo-norborn-2-yl)adenosine DM30KXV MI TTJFY5U DM30KXV MN Adenosine A3 receptor (ADORA3) DM30KXV MT DTT DM30KXV MA Inhibitor DM30KXV RN N6-Cycloalkyl- and N6-bicycloalkyl-C5'(C2')-modified adenosine derivatives as high-affinity and selective agonists at the human A1 adenosine recept... J Med Chem. 2009 Apr 23;52(8):2393-406. DM30KXV RU https://pubmed.ncbi.nlm.nih.gov/19317449 DM2W9NO DI DM2W9NO DM2W9NO DN N6-(3-Iodobenzyl)-2'-O-methyladenosine DM2W9NO MI TTJFY5U DM2W9NO MN Adenosine A3 receptor (ADORA3) DM2W9NO MT DTT DM2W9NO MA Inhibitor DM2W9NO RN Design, synthesis, and biological evaluation of LNA nucleosides as adenosine A3 receptor ligands. Bioorg Med Chem. 2007 Aug 15;15(16):5440-7. DM2W9NO RU https://pubmed.ncbi.nlm.nih.gov/17560111 DM5Q71U DI DM5Q71U DM5Q71U DN N6-(4-hydroxybenzyl)adenine riboside DM5Q71U MI TTM2AOE DM5Q71U MN Adenosine A2a receptor (ADORA2A) DM5Q71U MT DTT DM5Q71U MA Inhibitor DM5Q71U RN Neuroprotective principles from Gastrodia elata. J Nat Prod. 2007 Apr;70(4):571-4. DM5Q71U RU https://pubmed.ncbi.nlm.nih.gov/17381154 DM0WMKJ DI DM0WMKJ DM0WMKJ DN N6-[(4-Amino)-phenyl]-9-benzyl-2-phenyladenine DM0WMKJ MI TTK25J1 DM0WMKJ MN Adenosine A1 receptor (ADORA1) DM0WMKJ MT DTT DM0WMKJ MA Inhibitor DM0WMKJ RN N6-1,3-diphenylurea derivatives of 2-phenyl-9-benzyladenines and 8-azaadenines: synthesis and biological evaluation as allosteric modulators of A2A... Eur J Med Chem. 2008 Aug;43(8):1639-47. DM0WMKJ RU https://pubmed.ncbi.nlm.nih.gov/18045744 DM0WMKJ DI DM0WMKJ DM0WMKJ DN N6-[(4-Amino)-phenyl]-9-benzyl-2-phenyladenine DM0WMKJ MI TTM2AOE DM0WMKJ MN Adenosine A2a receptor (ADORA2A) DM0WMKJ MT DTT DM0WMKJ MA Inhibitor DM0WMKJ RN N6-1,3-diphenylurea derivatives of 2-phenyl-9-benzyladenines and 8-azaadenines: synthesis and biological evaluation as allosteric modulators of A2A... Eur J Med Chem. 2008 Aug;43(8):1639-47. DM0WMKJ RU https://pubmed.ncbi.nlm.nih.gov/18045744 DMVNLPF DI DMVNLPF DMVNLPF DN N6-[(4-Nitro)-phenyl]-9-benzyl-2-phenyladenine DMVNLPF MI TTK25J1 DMVNLPF MN Adenosine A1 receptor (ADORA1) DMVNLPF MT DTT DMVNLPF MA Inhibitor DMVNLPF RN N6-1,3-diphenylurea derivatives of 2-phenyl-9-benzyladenines and 8-azaadenines: synthesis and biological evaluation as allosteric modulators of A2A... Eur J Med Chem. 2008 Aug;43(8):1639-47. DMVNLPF RU https://pubmed.ncbi.nlm.nih.gov/18045744 DMVNLPF DI DMVNLPF DMVNLPF DN N6-[(4-Nitro)-phenyl]-9-benzyl-2-phenyladenine DMVNLPF MI TTM2AOE DMVNLPF MN Adenosine A2a receptor (ADORA2A) DMVNLPF MT DTT DMVNLPF MA Inhibitor DMVNLPF RN N6-1,3-diphenylurea derivatives of 2-phenyl-9-benzyladenines and 8-azaadenines: synthesis and biological evaluation as allosteric modulators of A2A... Eur J Med Chem. 2008 Aug;43(8):1639-47. DMVNLPF RU https://pubmed.ncbi.nlm.nih.gov/18045744 DMBT2HW DI DMBT2HW DMBT2HW DN N6-[4-(4-methylphenoxy)phenyl]-L-homoglutamine DMBT2HW MI TTXZEAJ DMBT2HW MN Leukotriene A-4 hydrolase (LTA4H) DMBT2HW MT DTT DMBT2HW MA Inhibitor DMBT2HW RN Synthesis of glutamic acid analogs as potent inhibitors of leukotriene A4 hydrolase. Bioorg Med Chem. 2008 May 1;16(9):4963-83. DMBT2HW RU https://pubmed.ncbi.nlm.nih.gov/18394906 DMDMI7P DI DMDMI7P DMDMI7P DN N-6060 DMDMI7P MI TTEP6RV DMDMI7P MN Glutathione reductase (GR) DMDMI7P MT DTT DMDMI7P MA Inhibitor DMDMI7P RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2613). DMDMI7P RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2613 DM814EQ DI DM814EQ DM814EQ DN N-6547 DM814EQ MI TTEP6RV DM814EQ MN Glutathione reductase (GR) DM814EQ MT DTT DM814EQ MA Inhibitor DM814EQ RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2613). DM814EQ RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2613 DM71MO2 DI DM71MO2 DM71MO2 DN N6-Benzyl Adenosine-5'-Diphosphate DM71MO2 MI TT6PKBN DM71MO2 MN Proto-oncogene c-Src (SRC) DM71MO2 MT DTT DM71MO2 MA Inhibitor DM71MO2 RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DM71MO2 RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMD6AJO DI DMD6AJO DMD6AJO DN N6-cyclopentyladenosine DMD6AJO MI TTK25J1 DMD6AJO MN Adenosine A1 receptor (ADORA1) DMD6AJO MT DTT DMD6AJO MA Inhibitor DMD6AJO RN 5'-Carbamoyl derivatives of 2'-C-methyl-purine nucleosides as selective A1 adenosine receptor agonists: affinity, efficacy, and selectivity for A1 ... Bioorg Med Chem. 2008 Jan 1;16(1):336-53. DMD6AJO RU https://pubmed.ncbi.nlm.nih.gov/17933541 DMD6AJO DI DMD6AJO DMD6AJO DN N6-cyclopentyladenosine DMD6AJO MI TTM2AOE DMD6AJO MN Adenosine A2a receptor (ADORA2A) DMD6AJO MT DTT DMD6AJO MA Inhibitor DMD6AJO RN 2-Amino-5-benzoyl-4-phenylthiazoles: Development of potent and selective adenosine A1 receptor antagonists. Bioorg Med Chem. 2010 Mar 15;18(6):2195-2203. DMD6AJO RU https://pubmed.ncbi.nlm.nih.gov/20188574 DMD6AJO DI DMD6AJO DMD6AJO DN N6-cyclopentyladenosine DMD6AJO MI TTNE7KG DMD6AJO MN Adenosine A2b receptor (ADORA2B) DMD6AJO MT DTT DMD6AJO MA Inhibitor DMD6AJO RN Adenosine receptor agonists: synthesis and biological evaluation of 1-deaza analogues of adenosine derivatives. J Med Chem. 1988 Jun;31(6):1179-83. DMD6AJO RU https://pubmed.ncbi.nlm.nih.gov/3373486 DMD6AJO DI DMD6AJO DMD6AJO DN N6-cyclopentyladenosine DMD6AJO MI TTJFY5U DMD6AJO MN Adenosine A3 receptor (ADORA3) DMD6AJO MT DTT DMD6AJO MA Inhibitor DMD6AJO RN Semi-rational design of (north)-methanocarba nucleosides as dual acting A(1) and A(3) adenosine receptor agonists: novel prototypes for cardioprote... J Med Chem. 2005 Dec 29;48(26):8103-7. DMD6AJO RU https://pubmed.ncbi.nlm.nih.gov/16366590 DMD6AJO DI DMD6AJO DMD6AJO DN N6-cyclopentyladenosine DMD6AJO MI TT2QM9D DMD6AJO MN Adenylate cyclase (ADCY) DMD6AJO MT DTT DMD6AJO MA Inhibitor DMD6AJO RN Activity of N6-substituted 2-chloroadenosines at A1 and A2 adenosine receptors. J Med Chem. 1991 Dec;34(12):3388-90. DMD6AJO RU https://pubmed.ncbi.nlm.nih.gov/1766003 DMD6AJO DI DMD6AJO DMD6AJO DN N6-cyclopentyladenosine DMD6AJO MI TTLXAKE DMD6AJO MN Solute carrier family 29 member 1 (SLC29A1) DMD6AJO MT DTT DMD6AJO MA Inhibitor DMD6AJO RN Inhibition of nucleoside transport proteins by C8-alkylamine-substituted purines. J Med Chem. 2005 Jan 13;48(1):321-9. DMD6AJO RU https://pubmed.ncbi.nlm.nih.gov/15634027 DMSEL5W DI DMSEL5W DMSEL5W DN N6-methoxy-2-[(2-pyridinyl)ethynyl]adenosine DMSEL5W MI TTK25J1 DMSEL5W MN Adenosine A1 receptor (ADORA1) DMSEL5W MT DTT DMSEL5W MA Inhibitor DMSEL5W RN N6-methoxy-2-alkynyladenosine derivatives as highly potent and selective ligands at the human A3 adenosine receptor. J Med Chem. 2007 Mar 22;50(6):1222-30. DMSEL5W RU https://pubmed.ncbi.nlm.nih.gov/17309246 DMSEL5W DI DMSEL5W DMSEL5W DN N6-methoxy-2-[(2-pyridinyl)ethynyl]adenosine DMSEL5W MI TTM2AOE DMSEL5W MN Adenosine A2a receptor (ADORA2A) DMSEL5W MT DTT DMSEL5W MA Inhibitor DMSEL5W RN N6-methoxy-2-alkynyladenosine derivatives as highly potent and selective ligands at the human A3 adenosine receptor. J Med Chem. 2007 Mar 22;50(6):1222-30. DMSEL5W RU https://pubmed.ncbi.nlm.nih.gov/17309246 DMSEL5W DI DMSEL5W DMSEL5W DN N6-methoxy-2-[(2-pyridinyl)ethynyl]adenosine DMSEL5W MI TTJFY5U DMSEL5W MN Adenosine A3 receptor (ADORA3) DMSEL5W MT DTT DMSEL5W MA Inhibitor DMSEL5W RN N6-methoxy-2-alkynyladenosine derivatives as highly potent and selective ligands at the human A3 adenosine receptor. J Med Chem. 2007 Mar 22;50(6):1222-30. DMSEL5W RU https://pubmed.ncbi.nlm.nih.gov/17309246 DMP7246 DI DMP7246 DMP7246 DN N6-methoxy-2-[(3-pyridinyl)ethynyl]-adenosine DMP7246 MI TTK25J1 DMP7246 MN Adenosine A1 receptor (ADORA1) DMP7246 MT DTT DMP7246 MA Inhibitor DMP7246 RN N6-methoxy-2-alkynyladenosine derivatives as highly potent and selective ligands at the human A3 adenosine receptor. J Med Chem. 2007 Mar 22;50(6):1222-30. DMP7246 RU https://pubmed.ncbi.nlm.nih.gov/17309246 DMP7246 DI DMP7246 DMP7246 DN N6-methoxy-2-[(3-pyridinyl)ethynyl]-adenosine DMP7246 MI TTM2AOE DMP7246 MN Adenosine A2a receptor (ADORA2A) DMP7246 MT DTT DMP7246 MA Inhibitor DMP7246 RN N6-methoxy-2-alkynyladenosine derivatives as highly potent and selective ligands at the human A3 adenosine receptor. J Med Chem. 2007 Mar 22;50(6):1222-30. DMP7246 RU https://pubmed.ncbi.nlm.nih.gov/17309246 DMP7246 DI DMP7246 DMP7246 DN N6-methoxy-2-[(3-pyridinyl)ethynyl]-adenosine DMP7246 MI TTJFY5U DMP7246 MN Adenosine A3 receptor (ADORA3) DMP7246 MT DTT DMP7246 MA Inhibitor DMP7246 RN N6-methoxy-2-alkynyladenosine derivatives as highly potent and selective ligands at the human A3 adenosine receptor. J Med Chem. 2007 Mar 22;50(6):1222-30. DMP7246 RU https://pubmed.ncbi.nlm.nih.gov/17309246 DM8LR62 DI DM8LR62 DM8LR62 DN N6-methoxy-2-[(4-methoxyphenyl)ethynyl]adenosine DM8LR62 MI TTK25J1 DM8LR62 MN Adenosine A1 receptor (ADORA1) DM8LR62 MT DTT DM8LR62 MA Inhibitor DM8LR62 RN N6-methoxy-2-alkynyladenosine derivatives as highly potent and selective ligands at the human A3 adenosine receptor. J Med Chem. 2007 Mar 22;50(6):1222-30. DM8LR62 RU https://pubmed.ncbi.nlm.nih.gov/17309246 DM8LR62 DI DM8LR62 DM8LR62 DN N6-methoxy-2-[(4-methoxyphenyl)ethynyl]adenosine DM8LR62 MI TTM2AOE DM8LR62 MN Adenosine A2a receptor (ADORA2A) DM8LR62 MT DTT DM8LR62 MA Inhibitor DM8LR62 RN N6-methoxy-2-alkynyladenosine derivatives as highly potent and selective ligands at the human A3 adenosine receptor. J Med Chem. 2007 Mar 22;50(6):1222-30. DM8LR62 RU https://pubmed.ncbi.nlm.nih.gov/17309246 DM8LR62 DI DM8LR62 DM8LR62 DN N6-methoxy-2-[(4-methoxyphenyl)ethynyl]adenosine DM8LR62 MI TTJFY5U DM8LR62 MN Adenosine A3 receptor (ADORA3) DM8LR62 MT DTT DM8LR62 MA Inhibitor DM8LR62 RN N6-methoxy-2-alkynyladenosine derivatives as highly potent and selective ligands at the human A3 adenosine receptor. J Med Chem. 2007 Mar 22;50(6):1222-30. DM8LR62 RU https://pubmed.ncbi.nlm.nih.gov/17309246 DM1KA9R DI DM1KA9R DM1KA9R DN N6-methoxy-2-[(4-methylphenyl)ethynyl]adenosine DM1KA9R MI TTK25J1 DM1KA9R MN Adenosine A1 receptor (ADORA1) DM1KA9R MT DTT DM1KA9R MA Inhibitor DM1KA9R RN N6-methoxy-2-alkynyladenosine derivatives as highly potent and selective ligands at the human A3 adenosine receptor. J Med Chem. 2007 Mar 22;50(6):1222-30. DM1KA9R RU https://pubmed.ncbi.nlm.nih.gov/17309246 DM1KA9R DI DM1KA9R DM1KA9R DN N6-methoxy-2-[(4-methylphenyl)ethynyl]adenosine DM1KA9R MI TTJFY5U DM1KA9R MN Adenosine A3 receptor (ADORA3) DM1KA9R MT DTT DM1KA9R MA Inhibitor DM1KA9R RN N6-methoxy-2-alkynyladenosine derivatives as highly potent and selective ligands at the human A3 adenosine receptor. J Med Chem. 2007 Mar 22;50(6):1222-30. DM1KA9R RU https://pubmed.ncbi.nlm.nih.gov/17309246 DMQ5K8R DI DMQ5K8R DMQ5K8R DN N6-methoxy-2-[(4-pentylphenyl)ethynyl]adenosine DMQ5K8R MI TTK25J1 DMQ5K8R MN Adenosine A1 receptor (ADORA1) DMQ5K8R MT DTT DMQ5K8R MA Inhibitor DMQ5K8R RN N6-methoxy-2-alkynyladenosine derivatives as highly potent and selective ligands at the human A3 adenosine receptor. J Med Chem. 2007 Mar 22;50(6):1222-30. DMQ5K8R RU https://pubmed.ncbi.nlm.nih.gov/17309246 DMQ5K8R DI DMQ5K8R DMQ5K8R DN N6-methoxy-2-[(4-pentylphenyl)ethynyl]adenosine DMQ5K8R MI TTM2AOE DMQ5K8R MN Adenosine A2a receptor (ADORA2A) DMQ5K8R MT DTT DMQ5K8R MA Inhibitor DMQ5K8R RN N6-methoxy-2-alkynyladenosine derivatives as highly potent and selective ligands at the human A3 adenosine receptor. J Med Chem. 2007 Mar 22;50(6):1222-30. DMQ5K8R RU https://pubmed.ncbi.nlm.nih.gov/17309246 DMQ5K8R DI DMQ5K8R DMQ5K8R DN N6-methoxy-2-[(4-pentylphenyl)ethynyl]adenosine DMQ5K8R MI TTJFY5U DMQ5K8R MN Adenosine A3 receptor (ADORA3) DMQ5K8R MT DTT DMQ5K8R MA Inhibitor DMQ5K8R RN N6-methoxy-2-alkynyladenosine derivatives as highly potent and selective ligands at the human A3 adenosine receptor. J Med Chem. 2007 Mar 22;50(6):1222-30. DMQ5K8R RU https://pubmed.ncbi.nlm.nih.gov/17309246 DM9H3W8 DI DM9H3W8 DM9H3W8 DN N6-methoxy-2-[(4-pyridinyl)ethynyl]adenosine DM9H3W8 MI TTK25J1 DM9H3W8 MN Adenosine A1 receptor (ADORA1) DM9H3W8 MT DTT DM9H3W8 MA Inhibitor DM9H3W8 RN N6-methoxy-2-alkynyladenosine derivatives as highly potent and selective ligands at the human A3 adenosine receptor. J Med Chem. 2007 Mar 22;50(6):1222-30. DM9H3W8 RU https://pubmed.ncbi.nlm.nih.gov/17309246 DM9H3W8 DI DM9H3W8 DM9H3W8 DN N6-methoxy-2-[(4-pyridinyl)ethynyl]adenosine DM9H3W8 MI TTM2AOE DM9H3W8 MN Adenosine A2a receptor (ADORA2A) DM9H3W8 MT DTT DM9H3W8 MA Inhibitor DM9H3W8 RN N6-methoxy-2-alkynyladenosine derivatives as highly potent and selective ligands at the human A3 adenosine receptor. J Med Chem. 2007 Mar 22;50(6):1222-30. DM9H3W8 RU https://pubmed.ncbi.nlm.nih.gov/17309246 DM9H3W8 DI DM9H3W8 DM9H3W8 DN N6-methoxy-2-[(4-pyridinyl)ethynyl]adenosine DM9H3W8 MI TTJFY5U DM9H3W8 MN Adenosine A3 receptor (ADORA3) DM9H3W8 MT DTT DM9H3W8 MA Inhibitor DM9H3W8 RN N6-methoxy-2-alkynyladenosine derivatives as highly potent and selective ligands at the human A3 adenosine receptor. J Med Chem. 2007 Mar 22;50(6):1222-30. DM9H3W8 RU https://pubmed.ncbi.nlm.nih.gov/17309246 DMRBS50 DI DMRBS50 DMRBS50 DN N6-methoxy-2-[2-(trimethylsilyl)ethynyl]adenosine DMRBS50 MI TTK25J1 DMRBS50 MN Adenosine A1 receptor (ADORA1) DMRBS50 MT DTT DMRBS50 MA Inhibitor DMRBS50 RN N6-methoxy-2-alkynyladenosine derivatives as highly potent and selective ligands at the human A3 adenosine receptor. J Med Chem. 2007 Mar 22;50(6):1222-30. DMRBS50 RU https://pubmed.ncbi.nlm.nih.gov/17309246 DMRBS50 DI DMRBS50 DMRBS50 DN N6-methoxy-2-[2-(trimethylsilyl)ethynyl]adenosine DMRBS50 MI TTM2AOE DMRBS50 MN Adenosine A2a receptor (ADORA2A) DMRBS50 MT DTT DMRBS50 MA Inhibitor DMRBS50 RN N6-methoxy-2-alkynyladenosine derivatives as highly potent and selective ligands at the human A3 adenosine receptor. J Med Chem. 2007 Mar 22;50(6):1222-30. DMRBS50 RU https://pubmed.ncbi.nlm.nih.gov/17309246 DMRBS50 DI DMRBS50 DMRBS50 DN N6-methoxy-2-[2-(trimethylsilyl)ethynyl]adenosine DMRBS50 MI TTJFY5U DMRBS50 MN Adenosine A3 receptor (ADORA3) DMRBS50 MT DTT DMRBS50 MA Inhibitor DMRBS50 RN N6-methoxy-2-alkynyladenosine derivatives as highly potent and selective ligands at the human A3 adenosine receptor. J Med Chem. 2007 Mar 22;50(6):1222-30. DMRBS50 RU https://pubmed.ncbi.nlm.nih.gov/17309246 DMDG59X DI DMDG59X DMDG59X DN N6-methoxy-2-phenylethynyladenosine DMDG59X MI TTK25J1 DMDG59X MN Adenosine A1 receptor (ADORA1) DMDG59X MT DTT DMDG59X MA Inhibitor DMDG59X RN N6-methoxy-2-alkynyladenosine derivatives as highly potent and selective ligands at the human A3 adenosine receptor. J Med Chem. 2007 Mar 22;50(6):1222-30. DMDG59X RU https://pubmed.ncbi.nlm.nih.gov/17309246 DMDG59X DI DMDG59X DMDG59X DN N6-methoxy-2-phenylethynyladenosine DMDG59X MI TTM2AOE DMDG59X MN Adenosine A2a receptor (ADORA2A) DMDG59X MT DTT DMDG59X MA Inhibitor DMDG59X RN N6-methoxy-2-alkynyladenosine derivatives as highly potent and selective ligands at the human A3 adenosine receptor. J Med Chem. 2007 Mar 22;50(6):1222-30. DMDG59X RU https://pubmed.ncbi.nlm.nih.gov/17309246 DMDG59X DI DMDG59X DMDG59X DN N6-methoxy-2-phenylethynyladenosine DMDG59X MI TTJFY5U DMDG59X MN Adenosine A3 receptor (ADORA3) DMDG59X MT DTT DMDG59X MA Inhibitor DMDG59X RN N6-methoxy-2-alkynyladenosine derivatives as highly potent and selective ligands at the human A3 adenosine receptor. J Med Chem. 2007 Mar 22;50(6):1222-30. DMDG59X RU https://pubmed.ncbi.nlm.nih.gov/17309246 DM6XDZA DI DM6XDZA DM6XDZA DN N7-hydroxy-2-methoxy-N1-phenylheptanediamide DM6XDZA MI TTSHTOI DM6XDZA MN Histone deacetylase 2 (HDAC2) DM6XDZA MT DTT DM6XDZA MA Inhibitor DM6XDZA RN Omega-alkoxy analogues of SAHA (vorinostat) as inhibitors of HDAC: a study of chain-length and stereochemical dependence. Bioorg Med Chem Lett. 2007 Nov 15;17(22):6261-5. DM6XDZA RU https://pubmed.ncbi.nlm.nih.gov/17892933 DMDJUZX DI DMDJUZX DMDJUZX DN N7-hydroxy-N1-phenyl-2-propoxyheptanediamide DMDJUZX MI TTSHTOI DMDJUZX MN Histone deacetylase 2 (HDAC2) DMDJUZX MT DTT DMDJUZX MA Inhibitor DMDJUZX RN Omega-alkoxy analogues of SAHA (vorinostat) as inhibitors of HDAC: a study of chain-length and stereochemical dependence. Bioorg Med Chem Lett. 2007 Nov 15;17(22):6261-5. DMDJUZX RU https://pubmed.ncbi.nlm.nih.gov/17892933 DMHC32M DI DMHC32M DMHC32M DN N8,2-dihydroxy-N1-phenyloctanediamide DMHC32M MI TTSHTOI DMHC32M MN Histone deacetylase 2 (HDAC2) DMHC32M MT DTT DMHC32M MA Inhibitor DMHC32M RN Omega-alkoxy analogues of SAHA (vorinostat) as inhibitors of HDAC: a study of chain-length and stereochemical dependence. Bioorg Med Chem Lett. 2007 Nov 15;17(22):6261-5. DMHC32M RU https://pubmed.ncbi.nlm.nih.gov/17892933 DM7OZ2T DI DM7OZ2T DM7OZ2T DN N8-hydroxy-2-methoxy-N1-phenyloctanediamide DM7OZ2T MI TTSHTOI DM7OZ2T MN Histone deacetylase 2 (HDAC2) DM7OZ2T MT DTT DM7OZ2T MA Inhibitor DM7OZ2T RN Omega-alkoxy analogues of SAHA (vorinostat) as inhibitors of HDAC: a study of chain-length and stereochemical dependence. Bioorg Med Chem Lett. 2007 Nov 15;17(22):6261-5. DM7OZ2T RU https://pubmed.ncbi.nlm.nih.gov/17892933 DMML1J4 DI DMML1J4 DMML1J4 DN N-9xxx DMML1J4 MI TTEP6RV DMML1J4 MN Glutathione reductase (GR) DMML1J4 MT DTT DMML1J4 MA Modulator DMML1J4 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2613). DMML1J4 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2613 DM51DW6 DI DM51DW6 DM51DW6 DN NAADP DM51DW6 MI TTEBMN7 DM51DW6 MN Long transient receptor potential channel 2 (TRPM2) DM51DW6 MT DTT DM51DW6 MA Activator DM51DW6 RN Nicotinic acid adenine dinucleotide phosphate and cyclic ADP-ribose regulate TRPM2 channels in T lymphocytes. FASEB J. 2006 May;20(7):962-4. DM51DW6 RU https://pubmed.ncbi.nlm.nih.gov/16585058 DM51DW6 DI DM51DW6 DM51DW6 DN NAADP DM51DW6 MI TTYXPCO DM51DW6 MN P2Y purinoceptor 11 (P2RY11) DM51DW6 MT DTT DM51DW6 MA Agonist DM51DW6 RN NAADP+ is an agonist of the human P2Y11 purinergic receptor. Cell Calcium. 2008 Apr;43(4):344-55. DM51DW6 RU https://pubmed.ncbi.nlm.nih.gov/17707504 DMFGOW0 DI DMFGOW0 DMFGOW0 DN NAAG DMFGOW0 MI TT8A9EF DMFGOW0 MN Metabotropic glutamate receptor 3 (mGluR3) DMFGOW0 MT DTT DMFGOW0 MA Agonist DMFGOW0 RN Characterization of [(3)H]-LY354740 binding to rat mGlu2 and mGlu3 receptors expressed in CHO cells using semliki forest virus vectors. Neuropharmacology. 2000 Jul 24;39(10):1700-6. DMFGOW0 RU https://pubmed.ncbi.nlm.nih.gov/10884552 DMFGOW0 DI DMFGOW0 DMFGOW0 DN NAAG DMFGOW0 MI DT9G7XN DMFGOW0 MN Peptide transporter 1 (SLC15A1) DMFGOW0 MT DTP DMFGOW0 MA Substrate DMFGOW0 RN Molecular interactions between dipeptides, drugs and the human intestinal H+ -oligopeptide cotransporter hPEPT1. J Physiol. 2006 Jul 1;574(Pt 1):149-66. DMFGOW0 RU https://doi.org/10.1113/jphysiol.2006.107904 DMFGOW0 DI DMFGOW0 DMFGOW0 DN NAAG DMFGOW0 MI DTWLACT DMFGOW0 MN Vesicular H(+)/Aspartate-glutamate cotransporter (SLC17A5) DMFGOW0 MT DTP DMFGOW0 MA Substrate DMFGOW0 RN Vesicular uptake of N-acetylaspartylglutamate is catalysed by sialin (SLC17A5). Biochem J. 2013 Aug 15;454(1):31-8. DMFGOW0 RU http://www.ncbi.nlm.nih.gov/pubmed/23889254 DMRKIYB DI DMRKIYB DMRKIYB DN NA-alpha-D-glucosamine DMRKIYB MI DEVSIE6 DMRKIYB MN Glyceraldehyde-3-phosphate dehydrogenase (gap) DMRKIYB MT DME DMRKIYB MA Metabolism DMRKIYB RN Cloning, expression and characterization of a mucin-binding GAPDH from Lactobacillus acidophilus. Int J Biol Macromol. 2016 Oct;91:338-46. DMRKIYB RU https://pubmed.ncbi.nlm.nih.gov/27180300 DMRKIYB DI DMRKIYB DMRKIYB DN NA-alpha-D-glucosamine DMRKIYB MI DER0EN5 DMRKIYB MN Phosphoglucomutase 3 (PGM3) DMRKIYB MT DME DMRKIYB MA Metabolism DMRKIYB RN Functional cloning and mutational analysis of the human cDNA for phosphoacetylglucosamine mutase: identification of the amino acid residues essential for the catalysis. Biochim Biophys Acta. 2000 Jul 24;1492(2-3):369-76. DMRKIYB RU https://www.ncbi.nlm.nih.gov/pubmed/?term=11004509 DMZW9AC DI DMZW9AC DMZW9AC DN N-Acetylalanine DMZW9AC MI TTFBNVI DMZW9AC MN Aldose reductase (AKR1B1) DMZW9AC MT DTT DMZW9AC MA Inhibitor DMZW9AC RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMZW9AC RU https://pubmed.ncbi.nlm.nih.gov/17139284 DM9WQ6V DI DM9WQ6V DM9WQ6V DN N-Acetylmethionine DM9WQ6V MI TTH0KSX DM9WQ6V MN Rhodopsin (RHO) DM9WQ6V MT DTT DM9WQ6V MA Inhibitor DM9WQ6V RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DM9WQ6V RU https://pubmed.ncbi.nlm.nih.gov/10592235 DMUNCFQ DI DMUNCFQ DMUNCFQ DN N-Acetyl-N'-Beta-D-Glucopyranosyl Urea DMUNCFQ MI TTZHY6R DMUNCFQ MN Glycogen phosphorylase muscle form (GP) DMUNCFQ MT DTT DMUNCFQ MA Inhibitor DMUNCFQ RN DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Nucleic Acids Res. 2011 Jan;39(Database issue):D1035-41. DMUNCFQ RU https://pubmed.ncbi.nlm.nih.gov/21059682 DME8O69 DI DME8O69 DME8O69 DN N-acetyl-phenylalanyl-glycine-nitrile DME8O69 MI TTDZN01 DME8O69 MN Cathepsin K (CTSK) DME8O69 MT DTT DME8O69 MA Inhibitor DME8O69 RN Interaction of papain-like cysteine proteases with dipeptide-derived nitriles. J Med Chem. 2005 Dec 1;48(24):7688-707. DME8O69 RU https://pubmed.ncbi.nlm.nih.gov/16302809 DME8O69 DI DME8O69 DME8O69 DN N-acetyl-phenylalanyl-glycine-nitrile DME8O69 MI TT36ETB DME8O69 MN Cathepsin L (CTSL) DME8O69 MT DTT DME8O69 MA Inhibitor DME8O69 RN Interaction of papain-like cysteine proteases with dipeptide-derived nitriles. J Med Chem. 2005 Dec 1;48(24):7688-707. DME8O69 RU https://pubmed.ncbi.nlm.nih.gov/16302809 DME8O69 DI DME8O69 DME8O69 DN N-acetyl-phenylalanyl-glycine-nitrile DME8O69 MI TTUMQVO DME8O69 MN Cathepsin S (CTSS) DME8O69 MT DTT DME8O69 MA Inhibitor DME8O69 RN Interaction of papain-like cysteine proteases with dipeptide-derived nitriles. J Med Chem. 2005 Dec 1;48(24):7688-707. DME8O69 RU https://pubmed.ncbi.nlm.nih.gov/16302809 DMJ4SBM DI DMJ4SBM DMJ4SBM DN N-acetylserotonin DMJ4SBM MI TT0WAIE DMJ4SBM MN Melatonin receptor type 1A (MTNR1A) DMJ4SBM MT DTT DMJ4SBM MA Inhibitor DMJ4SBM RN Synthesis of 2-amido-2,3-dihydro-1H-phenalene derivatives as new conformationally restricted ligands for melatonin receptors. J Med Chem. 1996 Aug 2;39(16):3089-95. DMJ4SBM RU https://pubmed.ncbi.nlm.nih.gov/8759629 DM1XH8D DI DM1XH8D DM1XH8D DN N'-Acridin-9-yl-N,N-diethyl-butane-1,4-diamine DM1XH8D MI TTFK1JQ DM1XH8D MN Voltage-gated calcium channel alpha-2/delta-1 (CACNA2D1) DM1XH8D MT DTT DM1XH8D MA Inhibitor DM1XH8D RN N-Acridin-9-yl-butane-1,4-diamine derivatives: high-affinity ligands of the alpha2delta subunit of voltage gated calcium channels. Bioorg Med Chem Lett. 2004 Apr 19;14(8):1913-6. DM1XH8D RU https://pubmed.ncbi.nlm.nih.gov/15050626 DM3ORGM DI DM3ORGM DM3ORGM DN NADA DM3ORGM MI TTXDKTO DM3ORGM MN Long transient receptor potential channel 8 (TRPM8) DM3ORGM MT DTT DM3ORGM MA Blocker (channel blocker) DM3ORGM RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 500). DM3ORGM RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=500 DM3ORGM DI DM3ORGM DM3ORGM DN NADA DM3ORGM MI TTMI6F5 DM3ORGM MN Transient receptor potential cation channel V1 (TRPV1) DM3ORGM MT DTT DM3ORGM MA Blocker (channel blocker) DM3ORGM RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 507). DM3ORGM RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=507 DMSR4A6 DI DMSR4A6 DMSR4A6 DN N-adamantanemethyloxypentyl-1-deoxynojirimycin DMSR4A6 MI TTLPC70 DMSR4A6 MN Lysosomal alpha-glucosidase (GAA) DMSR4A6 MT DTT DMSR4A6 MA Inhibitor DMSR4A6 RN Synthesis and evaluation of D-gluco-pyranocyclopropyl amines as potential glucosidase inhibitors. Bioorg Med Chem Lett. 2009 Dec 1;19(23):6600-3. DMSR4A6 RU https://pubmed.ncbi.nlm.nih.gov/19853441 DMZ43N1 DI DMZ43N1 DMZ43N1 DN N-adamantyl-N'-cyclohexylurea DMZ43N1 MI TT7WVHI DMZ43N1 MN Soluble epoxide hydrolase (EPHX2) DMZ43N1 MT DTT DMZ43N1 MA Inhibitor DMZ43N1 RN Orally bioavailable potent soluble epoxide hydrolase inhibitors. J Med Chem. 2007 Aug 9;50(16):3825-40. DMZ43N1 RU https://pubmed.ncbi.nlm.nih.gov/17616115 DM75Q34 DI DM75Q34 DM75Q34 DN NADPH DM75Q34 MI TTBE4IR DM75Q34 MN Plasmodium Oxoacyl-[acyl-carrier protein] reductase (Malaria fabG) DM75Q34 MT DTT DM75Q34 MA Cofactor DM75Q34 RN Functional characterization of beta-ketoacyl-ACP reductase (FabG) from Plasmodium falciparum. Biochem Biophys Res Commun. 2003 Mar 28;303(1):387-92. DM75Q34 RU https://pubmed.ncbi.nlm.nih.gov/12646215 DM38XWZ DI DM38XWZ DM38XWZ DN NAEPA DM38XWZ MI TTE2YJR DM38XWZ MN Lysophosphatidate-3 receptor (LPAR3) DM38XWZ MT DTT DM38XWZ MA Agonist DM38XWZ RN LPA and its analogs-attractive tools for elucidation of LPA biology and drug development. Curr Med Chem. 2008;15(21):2122-31. DM38XWZ RU https://pubmed.ncbi.nlm.nih.gov/18781939 DM38XWZ DI DM38XWZ DM38XWZ DN NAEPA DM38XWZ MI TTQ6S1K DM38XWZ MN Lysophosphatidic acid receptor 1 (LPAR1) DM38XWZ MT DTT DM38XWZ MA Agonist DM38XWZ RN LPA and its analogs-attractive tools for elucidation of LPA biology and drug development. Curr Med Chem. 2008;15(21):2122-31. DM38XWZ RU https://pubmed.ncbi.nlm.nih.gov/18781939 DM38XWZ DI DM38XWZ DM38XWZ DN NAEPA DM38XWZ MI TTB7Y8I DM38XWZ MN Lysophosphatidic acid receptor 2 (LPAR2) DM38XWZ MT DTT DM38XWZ MA Agonist DM38XWZ RN LPA and its analogs-attractive tools for elucidation of LPA biology and drug development. Curr Med Chem. 2008;15(21):2122-31. DM38XWZ RU https://pubmed.ncbi.nlm.nih.gov/18781939 DM79KLR DI DM79KLR DM79KLR DN nafadotride DM79KLR MI TTSQIFT DM79KLR MN 5-HT 1A receptor (HTR1A) DM79KLR MT DTT DM79KLR MA Agonist DM79KLR RN Agonist and antagonist actions of antipsychotic agents at 5-HT1A receptors: a [35S]GTPgammaS binding study. Eur J Pharmacol. 1998 Aug 21;355(2-3):245-56. DM79KLR RU https://pubmed.ncbi.nlm.nih.gov/9760039 DM79KLR DI DM79KLR DM79KLR DN nafadotride DM79KLR MI TTEX248 DM79KLR MN Dopamine D2 receptor (D2R) DM79KLR MT DTT DM79KLR MA Antagonist DM79KLR RN Nafadotride, a potent preferential dopamine D3 receptor antagonist, activates locomotion in rodents. J Pharmacol Exp Ther. 1995 Dec;275(3):1239-46. DM79KLR RU https://pubmed.ncbi.nlm.nih.gov/8531087 DM79KLR DI DM79KLR DM79KLR DN nafadotride DM79KLR MI TT4C8EA DM79KLR MN Dopamine D3 receptor (D3R) DM79KLR MT DTT DM79KLR MA Antagonist DM79KLR RN Nafadotride, a potent preferential dopamine D3 receptor antagonist, activates locomotion in rodents. J Pharmacol Exp Ther. 1995 Dec;275(3):1239-46. DM79KLR RU https://pubmed.ncbi.nlm.nih.gov/8531087 DM79KLR DI DM79KLR DM79KLR DN nafadotride DM79KLR MI TTE0A2F DM79KLR MN Dopamine D4 receptor (D4R) DM79KLR MT DTT DM79KLR MA Antagonist DM79KLR RN Nonconserved residues in the second transmembrane-spanning domain of the D(4) dopamine receptor are molecular determinants of D(4)-selective pharmacology. Mol Pharmacol. 2000 Jan;57(1):144-52. DM79KLR RU https://pubmed.ncbi.nlm.nih.gov/10617689 DM0FROP DI DM0FROP DM0FROP DN Nafoxidine DM0FROP MI TTZAYWL DM0FROP MN Estrogen receptor (ESR) DM0FROP MT DTT DM0FROP MA Inhibitor DM0FROP RN Discovery and preclinical pharmacology of a novel, potent, nonsteroidal estrogen receptor agonist/antagonist, CP-336156, a diaryltetrahydronaphthal... J Med Chem. 1998 Jul 30;41(16):2928-31. DM0FROP RU https://pubmed.ncbi.nlm.nih.gov/9685230 DM0FROP DI DM0FROP DM0FROP DN Nafoxidine DM0FROP MI TTOM3J0 DM0FROP MN Estrogen receptor beta (ESR2) DM0FROP MT DTT DM0FROP MA Inhibitor DM0FROP RN Discovery and preclinical pharmacology of a novel, potent, nonsteroidal estrogen receptor agonist/antagonist, CP-336156, a diaryltetrahydronaphthal... J Med Chem. 1998 Jul 30;41(16):2928-31. DM0FROP RU https://pubmed.ncbi.nlm.nih.gov/9685230 DM0FROP DI DM0FROP DM0FROP DN Nafoxidine DM0FROP MI DTUGYRD DM0FROP MN P-glycoprotein 1 (ABCB1) DM0FROP MT DTP DM0FROP MA Substrate DM0FROP RN Antiestrogens and steroid hormones: substrates of the human P-glycoprotein. Biochem Pharmacol. 1994 Jul 19;48(2):287-92. DM0FROP RU http://www.ncbi.nlm.nih.gov/pubmed/7914405 DML7UVA DI DML7UVA DML7UVA DN NAG 1-phosphate DML7UVA MI DETYWG5 DML7UVA MN UDP-N-acetylhexosamine pyrophosphorylase (AGX) DML7UVA MT DME DML7UVA MA Metabolism DML7UVA RN Crystal structures of two human pyrophosphorylase isoforms in complexes with UDPGlc(Gal)NAc: role of the alternatively spliced insert in the enzyme oligomeric assembly and active site architecture. EMBO J. 2001 Nov 15;20(22):6191-202. DML7UVA RU https://www.ncbi.nlm.nih.gov/pubmed/?term=11707391 DM1LWMU DI DM1LWMU DM1LWMU DN nahuoic acid A DM1LWMU MI TTGC95K DM1LWMU MN SET domain containing 8 (KMT5A) DM1LWMU MT DTT DM1LWMU MA Inhibitor DM1LWMU RN Nahuoic acid A produced by a Streptomyces sp. isolated from a marine sediment is a selective SAM-competitive inhibitor of the histone methyltransferase SETD8. Org Lett. 2013 Jan 18;15(2):414-7. DM1LWMU RU https://pubmed.ncbi.nlm.nih.gov/23272941 DM0CP36 DI DM0CP36 DM0CP36 DN NalBzOH DM0CP36 MI TTQW87Y DM0CP36 MN Opioid receptor kappa (OPRK1) DM0CP36 MT DTT DM0CP36 MA Inhibitor DM0CP36 RN Opiate receptor binding properties of morphine-, dihydromorphine-, and codeine 6-O-sulfate ester congeners. Bioorg Med Chem Lett. 2006 Aug 15;16(16):4291-5. DM0CP36 RU https://pubmed.ncbi.nlm.nih.gov/16777416 DM0CP36 DI DM0CP36 DM0CP36 DN NalBzOH DM0CP36 MI TTKWM86 DM0CP36 MN Opioid receptor mu (MOP) DM0CP36 MT DTT DM0CP36 MA Inhibitor DM0CP36 RN Opiate receptor binding properties of morphine-, dihydromorphine-, and codeine 6-O-sulfate ester congeners. Bioorg Med Chem Lett. 2006 Aug 15;16(16):4291-5. DM0CP36 RU https://pubmed.ncbi.nlm.nih.gov/16777416 DM9T0OK DI DM9T0OK DM9T0OK DN N-alkyl urea hydroxamic acids DM9T0OK MI TTICO5G DM9T0OK MN Staphylococcus Peptide deformylase (Stap-coc def) DM9T0OK MT DTT DM9T0OK MA Inhibitor DM9T0OK RN N-alkyl urea hydroxamic acids as a new class of peptide deformylase inhibitors with antibacterial activity. Antimicrob Agents Chemother. 2002 Sep;46(9):2752-64. DM9T0OK RU https://pubmed.ncbi.nlm.nih.gov/12183225 DM30LI6 DI DM30LI6 DM30LI6 DN N-allyl[D-Pro-10]Dyn A-(1-11) DM30LI6 MI TTQW87Y DM30LI6 MN Opioid receptor kappa (OPRK1) DM30LI6 MT DTT DM30LI6 MA Inhibitor DM30LI6 RN Synthesis and opioid activity of [D-Pro10]dynorphin A-(1-11) analogues with N-terminal alkyl substitution. J Med Chem. 1997 Aug 15;40(17):2733-9. DM30LI6 RU https://pubmed.ncbi.nlm.nih.gov/9276018 DMZQUMB DI DMZQUMB DMZQUMB DN N-allyl-4-hydroxy-N-phenylbenzenesulfonamide DMZQUMB MI TTZAYWL DMZQUMB MN Estrogen receptor (ESR) DMZQUMB MT DTT DMZQUMB MA Inhibitor DMZQUMB RN Substituted 4-hydroxyphenyl sulfonamides as pathway-selective estrogen receptor ligands. Bioorg Med Chem Lett. 2006 Feb 15;16(4):854-8. DMZQUMB RU https://pubmed.ncbi.nlm.nih.gov/16300947 DMRXA8N DI DMRXA8N DMRXA8N DN N-ALLYLNORGALANTHAMINE DMRXA8N MI TT1RS9F DMRXA8N MN Acetylcholinesterase (AChE) DMRXA8N MT DTT DMRXA8N MA Inhibitor DMRXA8N RN N-Alkylated galanthamine derivatives: Potent acetylcholinesterase inhibitors from Leucojum aestivum. Bioorg Med Chem Lett. 2008 Apr 1;18(7):2263-6. DMRXA8N RU https://pubmed.ncbi.nlm.nih.gov/18356045 DM5W2VK DI DM5W2VK DM5W2VK DN N-allylnorlitebamine DM5W2VK MI TT1RS9F DM5W2VK MN Acetylcholinesterase (AChE) DM5W2VK MT DTT DM5W2VK MA Inhibitor DM5W2VK RN Litebamine N-homologues: preparation and anti-acetylcholinesterase activity. J Nat Prod. 1998 Jan;61(1):46-50. DM5W2VK RU https://pubmed.ncbi.nlm.nih.gov/9461651 DM1SCU5 DI DM1SCU5 DM1SCU5 DN Nalorphine DM1SCU5 MI TTQW87Y DM1SCU5 MN Opioid receptor kappa (OPRK1) DM1SCU5 MT DTT DM1SCU5 MA Agonist DM1SCU5 RN Apparent efficacy of kappa-opioid receptor ligands on serum prolactin levels in rhesus monkeys. Eur J Pharmacol. 1999 Nov 3;383(3):305-9. DM1SCU5 RU https://pubmed.ncbi.nlm.nih.gov/10594324 DM8ZMNH DI DM8ZMNH DM8ZMNH DN naloxonazine DM8ZMNH MI TTKWM86 DM8ZMNH MN Opioid receptor mu (MOP) DM8ZMNH MT DTT DM8ZMNH MA Antagonist DM8ZMNH RN Pharmacological characterization of the cloned kappa-, delta-, and mu-opioid receptors. Mol Pharmacol. 1994 Feb;45(2):330-4. DM8ZMNH RU https://pubmed.ncbi.nlm.nih.gov/8114680 DMFNCQ1 DI DMFNCQ1 DMFNCQ1 DN N-alpha-amidino-Tyr(Me)-D-Pro-Gly-Trp-Phe-NH2 DMFNCQ1 MI TTKWM86 DMFNCQ1 MN Opioid receptor mu (MOP) DMFNCQ1 MT DTT DMFNCQ1 MA Inhibitor DMFNCQ1 RN Endomorphin-1 analogs with enhanced metabolic stability and systemic analgesic activity: design, synthesis, and pharmacological characterization. Bioorg Med Chem. 2007 Feb 15;15(4):1694-702. DMFNCQ1 RU https://pubmed.ncbi.nlm.nih.gov/17188879 DM8QTSU DI DM8QTSU DM8QTSU DN N-alpha-amidino-Tyr(Me)-Pro-Trp-p-Cl-Phe-NH2 DM8QTSU MI TT27RFC DM8QTSU MN Opioid receptor delta (OPRD1) DM8QTSU MT DTT DM8QTSU MA Inhibitor DM8QTSU RN Endomorphin-1 analogs with enhanced metabolic stability and systemic analgesic activity: design, synthesis, and pharmacological characterization. Bioorg Med Chem. 2007 Feb 15;15(4):1694-702. DM8QTSU RU https://pubmed.ncbi.nlm.nih.gov/17188879 DM8QTSU DI DM8QTSU DM8QTSU DN N-alpha-amidino-Tyr(Me)-Pro-Trp-p-Cl-Phe-NH2 DM8QTSU MI TTKWM86 DM8QTSU MN Opioid receptor mu (MOP) DM8QTSU MT DTT DM8QTSU MA Inhibitor DM8QTSU RN Endomorphin-1 analogs with enhanced metabolic stability and systemic analgesic activity: design, synthesis, and pharmacological characterization. Bioorg Med Chem. 2007 Feb 15;15(4):1694-702. DM8QTSU RU https://pubmed.ncbi.nlm.nih.gov/17188879 DMSC9FV DI DMSC9FV DMSC9FV DN N-alpha-amidino-Tyr(Me)-Pro-Trp-Phe-NH2 DMSC9FV MI TT27RFC DMSC9FV MN Opioid receptor delta (OPRD1) DMSC9FV MT DTT DMSC9FV MA Inhibitor DMSC9FV RN Endomorphin-1 analogs with enhanced metabolic stability and systemic analgesic activity: design, synthesis, and pharmacological characterization. Bioorg Med Chem. 2007 Feb 15;15(4):1694-702. DMSC9FV RU https://pubmed.ncbi.nlm.nih.gov/17188879 DMSC9FV DI DMSC9FV DMSC9FV DN N-alpha-amidino-Tyr(Me)-Pro-Trp-Phe-NH2 DMSC9FV MI TTKWM86 DMSC9FV MN Opioid receptor mu (MOP) DMSC9FV MT DTT DMSC9FV MA Inhibitor DMSC9FV RN Endomorphin-1 analogs with enhanced metabolic stability and systemic analgesic activity: design, synthesis, and pharmacological characterization. Bioorg Med Chem. 2007 Feb 15;15(4):1694-702. DMSC9FV RU https://pubmed.ncbi.nlm.nih.gov/17188879 DMRAN5O DI DMRAN5O DMRAN5O DN Naltrexone-6-alpha-ol DMRAN5O MI TT27RFC DMRAN5O MN Opioid receptor delta (OPRD1) DMRAN5O MT DTT DMRAN5O MA Inhibitor DMRAN5O RN Syntheses and opioid receptor binding properties of carboxamido-substituted opioids. Bioorg Med Chem Lett. 2009 Jan 1;19(1):203-8. DMRAN5O RU https://pubmed.ncbi.nlm.nih.gov/19027293 DMRAN5O DI DMRAN5O DMRAN5O DN Naltrexone-6-alpha-ol DMRAN5O MI TTQW87Y DMRAN5O MN Opioid receptor kappa (OPRK1) DMRAN5O MT DTT DMRAN5O MA Inhibitor DMRAN5O RN Syntheses and opioid receptor binding properties of carboxamido-substituted opioids. Bioorg Med Chem Lett. 2009 Jan 1;19(1):203-8. DMRAN5O RU https://pubmed.ncbi.nlm.nih.gov/19027293 DMRAN5O DI DMRAN5O DMRAN5O DN Naltrexone-6-alpha-ol DMRAN5O MI TTKWM86 DMRAN5O MN Opioid receptor mu (MOP) DMRAN5O MT DTT DMRAN5O MA Inhibitor DMRAN5O RN Syntheses and opioid receptor binding properties of carboxamido-substituted opioids. Bioorg Med Chem Lett. 2009 Jan 1;19(1):203-8. DMRAN5O RU https://pubmed.ncbi.nlm.nih.gov/19027293 DMNDOLZ DI DMNDOLZ DMNDOLZ DN naltriben DMNDOLZ MI TT27RFC DMNDOLZ MN Opioid receptor delta (OPRD1) DMNDOLZ MT DTT DMNDOLZ MA Antagonist DMNDOLZ RN Differential antagonism of delta opioid agonists by naltrindole and its benzofuran analog (NTB) in mice: evidence for delta opioid receptor subtypes. J Pharmacol Exp Ther. 1991 May;257(2):676-80. DMNDOLZ RU https://pubmed.ncbi.nlm.nih.gov/1851833 DMNDOLZ DI DMNDOLZ DMNDOLZ DN naltriben DMNDOLZ MI TTQW87Y DMNDOLZ MN Opioid receptor kappa (OPRK1) DMNDOLZ MT DTT DMNDOLZ MA Antagonist DMNDOLZ RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 318). DMNDOLZ RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=318 DMNDOLZ DI DMNDOLZ DMNDOLZ DN naltriben DMNDOLZ MI TTKWM86 DMNDOLZ MN Opioid receptor mu (MOP) DMNDOLZ MT DTT DMNDOLZ MA Antagonist DMNDOLZ RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 319). DMNDOLZ RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=319 DMWXBYC DI DMWXBYC DMWXBYC DN N-Aminoethylmorpholine DMWXBYC MI TTPT2QI DMWXBYC MN Cathepsin D (CTSD) DMWXBYC MT DTT DMWXBYC MA Inhibitor DMWXBYC RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMWXBYC RU https://pubmed.ncbi.nlm.nih.gov/17139284 DM1EZ3N DI DM1EZ3N DM1EZ3N DN Namn DM1EZ3N MI TTH29K0 DM1EZ3N MN Mycobacterium Nicotinate-nucleotide pyrophosphorylase (MycB nadC) DM1EZ3N MT DTT DM1EZ3N MA Inhibitor DM1EZ3N RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DM1EZ3N RU https://pubmed.ncbi.nlm.nih.gov/17139284 DM1EZ3N DI DM1EZ3N DM1EZ3N DN Namn DM1EZ3N MI DE4D159 DM1EZ3N MN Nicotinate-nucleotide adenylyltransferase 1 (NMNAT1) DM1EZ3N MT DME DM1EZ3N MA Metabolism DM1EZ3N RN Initial-rate kinetics of human NMN-adenylyltransferases: substrate and metal ion specificity, inhibition by products and multisubstrate analogues, and isozyme contributions to NAD+ biosynthesis. Biochemistry. 2007 Apr 24;46(16):4912-22. DM1EZ3N RU https://www.ncbi.nlm.nih.gov/pubmed/?term=17402747 DM1EZ3N DI DM1EZ3N DM1EZ3N DN Namn DM1EZ3N MI DE2HB58 DM1EZ3N MN Nicotinate-nucleotide adenylyltransferase 2 (NMNAT2) DM1EZ3N MT DME DM1EZ3N MA Metabolism DM1EZ3N RN Initial-rate kinetics of human NMN-adenylyltransferases: substrate and metal ion specificity, inhibition by products and multisubstrate analogues, and isozyme contributions to NAD+ biosynthesis. Biochemistry. 2007 Apr 24;46(16):4912-22. DM1EZ3N RU https://www.ncbi.nlm.nih.gov/pubmed/?term=17402747 DM1EZ3N DI DM1EZ3N DM1EZ3N DN Namn DM1EZ3N MI DERBKPU DM1EZ3N MN Nicotinate-nucleotide adenylyltransferase 3 (NMNAT3) DM1EZ3N MT DME DM1EZ3N MA Metabolism DM1EZ3N RN The NMN/NaMN adenylyltransferase (NMNAT) protein family. Front Biosci (Landmark Ed). 2009 Jan 1;14:410-31. DM1EZ3N RU https://www.ncbi.nlm.nih.gov/pubmed/?term=19273075 DMYDRB7 DI DMYDRB7 DMYDRB7 DN Naphthalen-1-yl 10H-phenothiazine-10-carboxylate DMYDRB7 MI TTEB0GD DMYDRB7 MN Cholinesterase (BCHE) DMYDRB7 MT DTT DMYDRB7 MA Inhibitor DMYDRB7 RN Carbamates with differential mechanism of inhibition toward acetylcholinesterase and butyrylcholinesterase. J Med Chem. 2008 Jul 24;51(14):4200-12. DMYDRB7 RU https://pubmed.ncbi.nlm.nih.gov/18570368 DM93CZW DI DM93CZW DM93CZW DN Naphthalen-1-yl(10H-phenothiazin-10-yl)methanone DM93CZW MI TTEB0GD DM93CZW MN Cholinesterase (BCHE) DM93CZW MT DTT DM93CZW MA Inhibitor DM93CZW RN Selective reversible inhibition of human butyrylcholinesterase by aryl amide derivatives of phenothiazine. Bioorg Med Chem. 2007 Oct 1;15(19):6367-78. DM93CZW RU https://pubmed.ncbi.nlm.nih.gov/17681768 DM08W6U DI DM08W6U DM08W6U DN Naphthalen-2-yl 10H-phenothiazine-10-carboxylate DM08W6U MI TTEB0GD DM08W6U MN Cholinesterase (BCHE) DM08W6U MT DTT DM08W6U MA Inhibitor DM08W6U RN Carbamates with differential mechanism of inhibition toward acetylcholinesterase and butyrylcholinesterase. J Med Chem. 2008 Jul 24;51(14):4200-12. DM08W6U RU https://pubmed.ncbi.nlm.nih.gov/18570368 DMDXM2A DI DMDXM2A DMDXM2A DN Naphthalen-2-yl cyclohexylcarbamate DMDXM2A MI TTDP1UC DMDXM2A MN Fatty acid amide hydrolase (FAAH) DMDXM2A MT DTT DMDXM2A MA Inhibitor DMDXM2A RN Discovery and development of fatty acid amide hydrolase (FAAH) inhibitors. J Med Chem. 2008 Dec 11;51(23):7327-43. DMDXM2A RU https://pubmed.ncbi.nlm.nih.gov/18983142 DMW8BXG DI DMW8BXG DMW8BXG DN Naphthalen-2-yl(10H-phenothiazin-10-yl)methanone DMW8BXG MI TTEB0GD DMW8BXG MN Cholinesterase (BCHE) DMW8BXG MT DTT DMW8BXG MA Inhibitor DMW8BXG RN Selective reversible inhibition of human butyrylcholinesterase by aryl amide derivatives of phenothiazine. Bioorg Med Chem. 2007 Oct 1;15(19):6367-78. DMW8BXG RU https://pubmed.ncbi.nlm.nih.gov/17681768 DML6FI3 DI DML6FI3 DML6FI3 DN Naphthalene Trisulfonate DML6FI3 MI TTMY81X DML6FI3 MN Heparin-binding growth factor 1 (FGF1) DML6FI3 MT DTT DML6FI3 MA Inhibitor DML6FI3 RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DML6FI3 RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMOQ43W DI DMOQ43W DMOQ43W DN Naphthalene-1,4-diol DMOQ43W MI TTZJYKH DMOQ43W MN Indoleamine 2,3-dioxygenase 1 (IDO1) DMOQ43W MT DTT DMOQ43W MA Inhibitor DMOQ43W RN Rational design of indoleamine 2,3-dioxygenase inhibitors. J Med Chem. 2010 Feb 11;53(3):1172-89. DMOQ43W RU https://pubmed.ncbi.nlm.nih.gov/20055453 DMLHWNG DI DMLHWNG DMLHWNG DN Naphthalene-2,6-disulfonic acid DMLHWNG MI TTAZHU0 DMLHWNG MN L-lactate dehydrogenase (LDH) DMLHWNG MT DTT DMLHWNG MA Inhibitor DMLHWNG RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DMLHWNG RU https://pubmed.ncbi.nlm.nih.gov/10592235 DMG8A74 DI DMG8A74 DMG8A74 DN Naphthalene-2-carboxylic acid hydroxyamide DMG8A74 MI TT2J34L DMG8A74 MN Arachidonate 5-lipoxygenase (5-LOX) DMG8A74 MT DTT DMG8A74 MA Inhibitor DMG8A74 RN Hydroxamic acid inhibitors of 5-lipoxygenase: quantitative structure-activity relationships. J Med Chem. 1990 Mar;33(3):992-8. DMG8A74 RU https://pubmed.ncbi.nlm.nih.gov/2308149 DMTWEQP DI DMTWEQP DMTWEQP DN Naphthyridinomycin DMTWEQP MI TTJP4SM DMTWEQP MN Bacterial Penicillin binding protein (Bact PBP) DMTWEQP MT DTT DMTWEQP RN Naphthyridinomycin-DNA adducts: a molecular modeling study. J Antibiot (Tokyo). 1991 Aug;44(8):885-94. DMTWEQP RU https://pubmed.ncbi.nlm.nih.gov/1917702 DM0OEGV DI DM0OEGV DM0OEGV DN NAPHTHYRIDINONE DM0OEGV MI TT6OEDT DM0OEGV MN Cannabinoid receptor 1 (CB1) DM0OEGV MT DTT DM0OEGV MA Inhibitor DM0OEGV RN Dihydro-pyrano[2,3-b]pyridines and tetrahydro-1,8-naphthyridines as CB1 receptor inverse agonists: synthesis, SAR and biological evaluation. Bioorg Med Chem Lett. 2010 Jun 15;20(12):3750-4. DM0OEGV RU https://pubmed.ncbi.nlm.nih.gov/20483606 DM0OEGV DI DM0OEGV DM0OEGV DN NAPHTHYRIDINONE DM0OEGV MI TTMSFAW DM0OEGV MN Cannabinoid receptor 2 (CB2) DM0OEGV MT DTT DM0OEGV MA Inhibitor DM0OEGV RN Synthesis of functionalized 1,8-naphthyridinones and their evaluation as novel, orally active CB1 receptor inverse agonists. Bioorg Med Chem Lett. 2006 Feb;16(3):681-5. DM0OEGV RU https://pubmed.ncbi.nlm.nih.gov/16263284 DM8F5LR DI DM8F5LR DM8F5LR DN NAPQI DM8F5LR MI TT2AST1 DM8F5LR MN Macrophage migration inhibitory factor (MIF) DM8F5LR MT DTT DM8F5LR MA Inhibitor DM8F5LR RN MIF in autoimmunity and novel therapeutic approaches. Autoimmun Rev. 2009 Jan;8(3):244-9. DM8F5LR RU https://pubmed.ncbi.nlm.nih.gov/18721909 DM85RJ1 DI DM85RJ1 DM85RJ1 DN N-arachidonoylglycine DM85RJ1 MI TTABCJ6 DM85RJ1 MN Lysophosphatidic acid receptor 5 (LPAR5) DM85RJ1 MT DTT DM85RJ1 MA Agonist DM85RJ1 RN Identification of farnesyl pyrophosphate and N-arachidonylglycine as endogenous ligands for GPR92. J Biol Chem. 2008 Jul 25;283(30):21054-64. DM85RJ1 RU https://pubmed.ncbi.nlm.nih.gov/18499677 DM85RJ1 DI DM85RJ1 DM85RJ1 DN N-arachidonoylglycine DM85RJ1 MI TTSLJAR DM85RJ1 MN N-arachidonyl glycine receptor (GPR18) DM85RJ1 MT DTT DM85RJ1 MA Agonist DM85RJ1 RN Identification of N-arachidonylglycine as the endogenous ligand for orphan G-protein-coupled receptor GPR18. Biochem Biophys Res Commun. 2006 Sep 1;347(3):827-32. DM85RJ1 RU https://pubmed.ncbi.nlm.nih.gov/16844083 DMF9U2O DI DMF9U2O DMF9U2O DN N-arachidonoyl-N-(2-hydroxyethyl)hydroxylamine DMF9U2O MI TT6OEDT DMF9U2O MN Cannabinoid receptor 1 (CB1) DMF9U2O MT DTT DMF9U2O MA Inhibitor DMF9U2O RN Oxyhomologues of anandamide and related endolipids: chemoselective synthesis and biological activity. J Med Chem. 2006 Apr 6;49(7):2333-8. DMF9U2O RU https://pubmed.ncbi.nlm.nih.gov/16570929 DMF9U2O DI DMF9U2O DMF9U2O DN N-arachidonoyl-N-(2-hydroxyethyl)hydroxylamine DMF9U2O MI TTMSFAW DMF9U2O MN Cannabinoid receptor 2 (CB2) DMF9U2O MT DTT DMF9U2O MA Inhibitor DMF9U2O RN Oxyhomologues of anandamide and related endolipids: chemoselective synthesis and biological activity. J Med Chem. 2006 Apr 6;49(7):2333-8. DMF9U2O RU https://pubmed.ncbi.nlm.nih.gov/16570929 DM49HIO DI DM49HIO DM49HIO DN N-arachidonoyl-O-(2-hydroxyethyl)hydroxylamine DM49HIO MI TT6OEDT DM49HIO MN Cannabinoid receptor 1 (CB1) DM49HIO MT DTT DM49HIO MA Inhibitor DM49HIO RN Oxyhomologues of anandamide and related endolipids: chemoselective synthesis and biological activity. J Med Chem. 2006 Apr 6;49(7):2333-8. DM49HIO RU https://pubmed.ncbi.nlm.nih.gov/16570929 DM49HIO DI DM49HIO DM49HIO DN N-arachidonoyl-O-(2-hydroxyethyl)hydroxylamine DM49HIO MI TTMSFAW DM49HIO MN Cannabinoid receptor 2 (CB2) DM49HIO MT DTT DM49HIO MA Inhibitor DM49HIO RN Oxyhomologues of anandamide and related endolipids: chemoselective synthesis and biological activity. J Med Chem. 2006 Apr 6;49(7):2333-8. DM49HIO RU https://pubmed.ncbi.nlm.nih.gov/16570929 DMLVGT8 DI DMLVGT8 DMLVGT8 DN N-arachidonylmaleimide DMLVGT8 MI TTDP1UC DMLVGT8 MN Fatty acid amide hydrolase (FAAH) DMLVGT8 MT DTT DMLVGT8 MA Inhibitor DMLVGT8 RN Synthesis and in vitro evaluation of N-substituted maleimide derivatives as selective monoglyceride lipase inhibitors. J Med Chem. 2009 Dec 10;52(23):7410-20. DMLVGT8 RU https://pubmed.ncbi.nlm.nih.gov/19583260 DMI7A6R DI DMI7A6R DMI7A6R DN Narciclasine DMI7A6R MI TT8R0BZ DMI7A6R MN Elongation factor 1A (EF1A) DMI7A6R MT DTT DMI7A6R MA Inhibitor DMI7A6R RN Targeting of eEF1A with Amaryllidaceae isocarbostyrils as a strategy to combat melanomas. FASEB J. 2010 Nov;24(11):4575-84. DMI7A6R RU https://pubmed.ncbi.nlm.nih.gov/20643906 DMMUABE DI DMMUABE DMMUABE DN Naringin DMMUABE MI DEBI82Z DMMUABE MN Alpha-L-rhamnosidase (lrA) DMMUABE MT DME DMMUABE MA Metabolism DMMUABE RN Metabolism of rutin and poncirin by human intestinal microbiota and cloning of their metabolizing alpha-L-rhamnosidase from Bifidobacterium dentium. J Microbiol Biotechnol. 2015 Jan;25(1):18-25. DMMUABE RU https://pubmed.ncbi.nlm.nih.gov/25179902 DM4DG1Y DI DM4DG1Y DM4DG1Y DN Naringin DM4DG1Y MI TTUGD21 DM4DG1Y MN Sodium-independent organic anion transporter (SLCO1A2) DM4DG1Y MT DTT DM4DG1Y MA Inhibitor DM4DG1Y RN Naringin is a major and selective clinical inhibitor of organic anion-transporting polypeptide 1A2 (OATP1A2) in grapefruit juice. Clin Pharmacol Ther. 2007 Apr;81(4):495-502. DM4DG1Y RU https://pubmed.ncbi.nlm.nih.gov/17301733 DM3RP25 DI DM3RP25 DM3RP25 DN NAVPNLRGDLQVLAQKVART DM3RP25 MI TTT1R2L DM3RP25 MN Integrin alpha-V (ITGAV) DM3RP25 MT DTT DM3RP25 MA Inhibitor DM3RP25 RN Structure-function analysis of Arg-Gly-Asp helix motifs in alpha v beta 6 integrin ligands. J Biol Chem. 2007 Mar 30;282(13):9657-65. DM3RP25 RU https://pubmed.ncbi.nlm.nih.gov/17244604 DMO6T9C DI DMO6T9C DMO6T9C DN NAX-5055 DMO6T9C MI TTX3HNZ DMO6T9C MN Galanin receptor type 1 (GAL1-R) DMO6T9C MT DTT DMO6T9C MA Agonist DMO6T9C RN Progress report on new antiepileptic drugs: a summary of the Ninth Eilat Conference (EILAT IX). Epilepsy Res. 2009 Jan;83(1):1-43. DMO6T9C RU https://pubmed.ncbi.nlm.nih.gov/19008076 DMNM6GQ DI DMNM6GQ DMNM6GQ DN NB3178 DMNM6GQ MI TT9SL3Q DMNM6GQ MN Polypeptide deformylase (PDF) DMNM6GQ MT DTT DMNM6GQ MA Inhibitor DMNM6GQ RN Emerging drugs for bacterial urinary tract infections. Expert Opin Emerg Drugs. 2005 May;10(2):275-98. DMNM6GQ RU https://pubmed.ncbi.nlm.nih.gov/15934867 DM7K36E DI DM7K36E DM7K36E DN NB-325 DM7K36E MI TTBID49 DM7K36E MN C-X-C chemokine receptor type 4 (CXCR4) DM7K36E MT DTT DM7K36E MA Modulator DM7K36E RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 71). DM7K36E RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=71 DMJHWGS DI DMJHWGS DMJHWGS DN NB3322 DMJHWGS MI TT9SL3Q DMJHWGS MN Polypeptide deformylase (PDF) DMJHWGS MT DTT DMJHWGS MA Inhibitor DMJHWGS RN Emerging drugs for bacterial urinary tract infections. Expert Opin Emerg Drugs. 2005 May;10(2):275-98. DMJHWGS RU https://pubmed.ncbi.nlm.nih.gov/15934867 DMTZ1XV DI DMTZ1XV DMTZ1XV DN NBBCC DMTZ1XV MI TTZ8EM9 DMTZ1XV MN Glycine receptor (GlyR) DMTZ1XV MT DTT DMTZ1XV RN Developmental regulation of beta-carboline-induced inhibition of glycine-evoked responses depends on glycine receptor beta subunit expression. Mol Pharmacol. 2005 May;67(5):1783-96. DMTZ1XV RU https://pubmed.ncbi.nlm.nih.gov/15722459 DMX0Y79 DI DMX0Y79 DMX0Y79 DN N-BENZOYL-D-ALANINE DMX0Y79 MI TT329FH DMX0Y79 MN Bacterial Penicillin-binding protein 1B (Bact mrcB) DMX0Y79 MT DTT DMX0Y79 MA Inhibitor DMX0Y79 RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DMX0Y79 RU https://pubmed.ncbi.nlm.nih.gov/10592235 DM7U81L DI DM7U81L DM7U81L DN N-Benzoyl-N'-Beta-D-Glucopyranosyl Urea DM7U81L MI TTZHY6R DM7U81L MN Glycogen phosphorylase muscle form (GP) DM7U81L MT DTT DM7U81L MA Inhibitor DM7U81L RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DM7U81L RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMRJ4B1 DI DMRJ4B1 DMRJ4B1 DN N-benzoyl-phenylalanyl-glycine-nitrile DMRJ4B1 MI TTDZN01 DMRJ4B1 MN Cathepsin K (CTSK) DMRJ4B1 MT DTT DMRJ4B1 MA Inhibitor DMRJ4B1 RN Interaction of papain-like cysteine proteases with dipeptide-derived nitriles. J Med Chem. 2005 Dec 1;48(24):7688-707. DMRJ4B1 RU https://pubmed.ncbi.nlm.nih.gov/16302809 DMRJ4B1 DI DMRJ4B1 DMRJ4B1 DN N-benzoyl-phenylalanyl-glycine-nitrile DMRJ4B1 MI TT36ETB DMRJ4B1 MN Cathepsin L (CTSL) DMRJ4B1 MT DTT DMRJ4B1 MA Inhibitor DMRJ4B1 RN Interaction of papain-like cysteine proteases with dipeptide-derived nitriles. J Med Chem. 2005 Dec 1;48(24):7688-707. DMRJ4B1 RU https://pubmed.ncbi.nlm.nih.gov/16302809 DMRJ4B1 DI DMRJ4B1 DMRJ4B1 DN N-benzoyl-phenylalanyl-glycine-nitrile DMRJ4B1 MI TTUMQVO DMRJ4B1 MN Cathepsin S (CTSS) DMRJ4B1 MT DTT DMRJ4B1 MA Inhibitor DMRJ4B1 RN Interaction of papain-like cysteine proteases with dipeptide-derived nitriles. J Med Chem. 2005 Dec 1;48(24):7688-707. DMRJ4B1 RU https://pubmed.ncbi.nlm.nih.gov/16302809 DMOQMEU DI DMOQMEU DMOQMEU DN N-benzyl brucine DMOQMEU MI TTOXS3C DMOQMEU MN Muscarinic acetylcholine receptor (CHRM) DMOQMEU MT DTT DMOQMEU MA Modulator (allosteric modulator) DMOQMEU RN Subtype-selective positive cooperative interactions between brucine analogues and acetylcholine at muscarinic receptors: radioligand binding studies. Mol Pharmacol. 1998 Mar;53(3):573-89. DMOQMEU RU https://pubmed.ncbi.nlm.nih.gov/9495826 DMOQMEU DI DMOQMEU DMOQMEU DN N-benzyl brucine DMOQMEU MI TTQ13Z5 DMOQMEU MN Muscarinic acetylcholine receptor M3 (CHRM3) DMOQMEU MT DTT DMOQMEU MA Modulator (allosteric modulator) DMOQMEU RN Subtype-selective positive cooperative interactions between brucine analogues and acetylcholine at muscarinic receptors: radioligand binding studies. Mol Pharmacol. 1998 Mar;53(3):573-89. DMOQMEU RU https://pubmed.ncbi.nlm.nih.gov/9495826 DMN9WZ3 DI DMN9WZ3 DMN9WZ3 DN N-Benzyl-(6-butoxy-2-naphthyl)-2-aminopropane DMN9WZ3 MI TT3WG5C DMN9WZ3 MN Monoamine oxidase type A (MAO-A) DMN9WZ3 MT DTT DMN9WZ3 MA Inhibitor DMN9WZ3 RN Naphthylisopropylamine and N-benzylamphetamine derivatives as monoamine oxidase inhibitors. Bioorg Med Chem. 2009 Mar 15;17(6):2452-60. DMN9WZ3 RU https://pubmed.ncbi.nlm.nih.gov/19243954 DMKJ6F8 DI DMKJ6F8 DMKJ6F8 DN N-Benzyl-(6-methoxy-2-naphthyl)-2-aminopropane DMKJ6F8 MI TT3WG5C DMKJ6F8 MN Monoamine oxidase type A (MAO-A) DMKJ6F8 MT DTT DMKJ6F8 MA Inhibitor DMKJ6F8 RN Naphthylisopropylamine and N-benzylamphetamine derivatives as monoamine oxidase inhibitors. Bioorg Med Chem. 2009 Mar 15;17(6):2452-60. DMKJ6F8 RU https://pubmed.ncbi.nlm.nih.gov/19243954 DMHVRFM DI DMHVRFM DMHVRFM DN N-Benzyl,N-methyl-1H-indole-2-carboxamide DMHVRFM MI TT3WG5C DMHVRFM MN Monoamine oxidase type A (MAO-A) DMHVRFM MT DTT DMHVRFM MA Inhibitor DMHVRFM RN Synthesis, structure-activity relationships and molecular modeling studies of new indole inhibitors of monoamine oxidases A and B. Bioorg Med Chem. 2008 Nov 15;16(22):9729-40. DMHVRFM RU https://pubmed.ncbi.nlm.nih.gov/18951803 DMHVRFM DI DMHVRFM DMHVRFM DN N-Benzyl,N-methyl-1H-indole-2-carboxamide DMHVRFM MI TTGP7BY DMHVRFM MN Monoamine oxidase type B (MAO-B) DMHVRFM MT DTT DMHVRFM MA Inhibitor DMHVRFM RN Synthesis, structure-activity relationships and molecular modeling studies of new indole inhibitors of monoamine oxidases A and B. Bioorg Med Chem. 2008 Nov 15;16(22):9729-40. DMHVRFM RU https://pubmed.ncbi.nlm.nih.gov/18951803 DM8I7N2 DI DM8I7N2 DM8I7N2 DN N-benzyl,N-methyl-1H-pyrrole-2-carboxamide DM8I7N2 MI TT3WG5C DM8I7N2 MN Monoamine oxidase type A (MAO-A) DM8I7N2 MT DTT DM8I7N2 MA Inhibitor DM8I7N2 RN New pyrrole inhibitors of monoamine oxidase: synthesis, biological evaluation, and structural determinants of MAO-A and MAO-B selectivity. J Med Chem. 2007 Mar 8;50(5):922-31. DM8I7N2 RU https://pubmed.ncbi.nlm.nih.gov/17256833 DM2YZC5 DI DM2YZC5 DM2YZC5 DN N-benzyl[D-Pro-10]Dyn A-(1-11) DM2YZC5 MI TTQW87Y DM2YZC5 MN Opioid receptor kappa (OPRK1) DM2YZC5 MT DTT DM2YZC5 MA Inhibitor DM2YZC5 RN Synthesis and opioid activity of [D-Pro10]dynorphin A-(1-11) analogues with N-terminal alkyl substitution. J Med Chem. 1997 Aug 15;40(17):2733-9. DM2YZC5 RU https://pubmed.ncbi.nlm.nih.gov/9276018 DM7SEM1 DI DM7SEM1 DM7SEM1 DN N-Benzyl-17-(cyclobutylmethyl)morphinan-3-amine DM7SEM1 MI TT27RFC DM7SEM1 MN Opioid receptor delta (OPRD1) DM7SEM1 MT DTT DM7SEM1 MA Inhibitor DM7SEM1 RN Synthesis and opioid receptor binding affinities of 2-substituted and 3-aminomorphinans: ligands for mu, kappa, and delta opioid receptors. J Med Chem. 2010 Jan 14;53(1):402-18. DM7SEM1 RU https://pubmed.ncbi.nlm.nih.gov/19928862 DM7SEM1 DI DM7SEM1 DM7SEM1 DN N-Benzyl-17-(cyclobutylmethyl)morphinan-3-amine DM7SEM1 MI TTQW87Y DM7SEM1 MN Opioid receptor kappa (OPRK1) DM7SEM1 MT DTT DM7SEM1 MA Inhibitor DM7SEM1 RN Synthesis and opioid receptor binding affinities of 2-substituted and 3-aminomorphinans: ligands for mu, kappa, and delta opioid receptors. J Med Chem. 2010 Jan 14;53(1):402-18. DM7SEM1 RU https://pubmed.ncbi.nlm.nih.gov/19928862 DM7SEM1 DI DM7SEM1 DM7SEM1 DN N-Benzyl-17-(cyclobutylmethyl)morphinan-3-amine DM7SEM1 MI TTKWM86 DM7SEM1 MN Opioid receptor mu (MOP) DM7SEM1 MT DTT DM7SEM1 MA Inhibitor DM7SEM1 RN Synthesis and opioid receptor binding affinities of 2-substituted and 3-aminomorphinans: ligands for mu, kappa, and delta opioid receptors. J Med Chem. 2010 Jan 14;53(1):402-18. DM7SEM1 RU https://pubmed.ncbi.nlm.nih.gov/19928862 DMLP9VM DI DMLP9VM DMLP9VM DN N-Benzyl-17-(cyclopropylmethyl)morphinan-3-amine DMLP9VM MI TT27RFC DMLP9VM MN Opioid receptor delta (OPRD1) DMLP9VM MT DTT DMLP9VM MA Inhibitor DMLP9VM RN Synthesis and opioid receptor binding affinities of 2-substituted and 3-aminomorphinans: ligands for mu, kappa, and delta opioid receptors. J Med Chem. 2010 Jan 14;53(1):402-18. DMLP9VM RU https://pubmed.ncbi.nlm.nih.gov/19928862 DMLP9VM DI DMLP9VM DMLP9VM DN N-Benzyl-17-(cyclopropylmethyl)morphinan-3-amine DMLP9VM MI TTQW87Y DMLP9VM MN Opioid receptor kappa (OPRK1) DMLP9VM MT DTT DMLP9VM MA Inhibitor DMLP9VM RN Synthesis and opioid receptor binding affinities of 2-substituted and 3-aminomorphinans: ligands for mu, kappa, and delta opioid receptors. J Med Chem. 2010 Jan 14;53(1):402-18. DMLP9VM RU https://pubmed.ncbi.nlm.nih.gov/19928862 DMLP9VM DI DMLP9VM DMLP9VM DN N-Benzyl-17-(cyclopropylmethyl)morphinan-3-amine DMLP9VM MI TTKWM86 DMLP9VM MN Opioid receptor mu (MOP) DMLP9VM MT DTT DMLP9VM MA Inhibitor DMLP9VM RN Synthesis and opioid receptor binding affinities of 2-substituted and 3-aminomorphinans: ligands for mu, kappa, and delta opioid receptors. J Med Chem. 2010 Jan 14;53(1):402-18. DMLP9VM RU https://pubmed.ncbi.nlm.nih.gov/19928862 DMA3YWU DI DMA3YWU DMA3YWU DN N-Benzyl-1H-indole-2-carboxamide DMA3YWU MI TT3WG5C DMA3YWU MN Monoamine oxidase type A (MAO-A) DMA3YWU MT DTT DMA3YWU MA Inhibitor DMA3YWU RN Synthesis, structure-activity relationships and molecular modeling studies of new indole inhibitors of monoamine oxidases A and B. Bioorg Med Chem. 2008 Nov 15;16(22):9729-40. DMA3YWU RU https://pubmed.ncbi.nlm.nih.gov/18951803 DMA3YWU DI DMA3YWU DMA3YWU DN N-Benzyl-1H-indole-2-carboxamide DMA3YWU MI TTGP7BY DMA3YWU MN Monoamine oxidase type B (MAO-B) DMA3YWU MT DTT DMA3YWU MA Inhibitor DMA3YWU RN Synthesis, structure-activity relationships and molecular modeling studies of new indole inhibitors of monoamine oxidases A and B. Bioorg Med Chem. 2008 Nov 15;16(22):9729-40. DMA3YWU RU https://pubmed.ncbi.nlm.nih.gov/18951803 DMC7XST DI DMC7XST DMC7XST DN N-Benzyl-1'H-phenothiazine-1'-carboxamide DMC7XST MI TTEB0GD DMC7XST MN Cholinesterase (BCHE) DMC7XST MT DTT DMC7XST MA Inhibitor DMC7XST RN Differential binding of phenothiazine urea derivatives to wild-type human cholinesterases and butyrylcholinesterase mutants. Bioorg Med Chem. 2010 Mar 15;18(6):2232-2244. DMC7XST RU https://pubmed.ncbi.nlm.nih.gov/20181484 DM73ZHV DI DM73ZHV DM73ZHV DN N-benzyl-1H-pyrrole-2-carboxamide DM73ZHV MI TT3WG5C DM73ZHV MN Monoamine oxidase type A (MAO-A) DM73ZHV MT DTT DM73ZHV MA Inhibitor DM73ZHV RN New pyrrole inhibitors of monoamine oxidase: synthesis, biological evaluation, and structural determinants of MAO-A and MAO-B selectivity. J Med Chem. 2007 Mar 8;50(5):922-31. DM73ZHV RU https://pubmed.ncbi.nlm.nih.gov/17256833 DM8A23B DI DM8A23B DM8A23B DN N-Benzyl-2-(1H-indol-3-yl)-2-oxo-acetamide DM8A23B MI TT1MPAY DM8A23B MN GABA(A) receptor alpha-1 (GABRA1) DM8A23B MT DTT DM8A23B MA Inhibitor DM8A23B RN Novel N-substituted indol-3-ylglyoxylamides probing the LDi and L1/L2 lipophilic regions of the benzodiazepine receptor site in search for subtype-... J Med Chem. 2007 Apr 5;50(7):1627-34. DM8A23B RU https://pubmed.ncbi.nlm.nih.gov/17335185 DM8A23B DI DM8A23B DM8A23B DN N-Benzyl-2-(1H-indol-3-yl)-2-oxo-acetamide DM8A23B MI TTZA1NY DM8A23B MN GABA(A) receptor beta-2 (GABRB2) DM8A23B MT DTT DM8A23B MA Inhibitor DM8A23B RN Novel N-substituted indol-3-ylglyoxylamides probing the LDi and L1/L2 lipophilic regions of the benzodiazepine receptor site in search for subtype-... J Med Chem. 2007 Apr 5;50(7):1627-34. DM8A23B RU https://pubmed.ncbi.nlm.nih.gov/17335185 DM8A23B DI DM8A23B DM8A23B DN N-Benzyl-2-(1H-indol-3-yl)-2-oxo-acetamide DM8A23B MI TT06RH5 DM8A23B MN GABA(A) receptor gamma-2 (GABRG2) DM8A23B MT DTT DM8A23B MA Inhibitor DM8A23B RN Novel N-substituted indol-3-ylglyoxylamides probing the LDi and L1/L2 lipophilic regions of the benzodiazepine receptor site in search for subtype-... J Med Chem. 2007 Apr 5;50(7):1627-34. DM8A23B RU https://pubmed.ncbi.nlm.nih.gov/17335185 DM8A23B DI DM8A23B DM8A23B DN N-Benzyl-2-(1H-indol-3-yl)-2-oxo-acetamide DM8A23B MI TTNJYV2 DM8A23B MN Gamma-aminobutyric acid receptor (GAR) DM8A23B MT DTT DM8A23B MA Inhibitor DM8A23B RN N'-Phenylindol-3-ylglyoxylohydrazide derivatives: synthesis, structure-activity relationships, molecular modeling studies, and pharmacological acti... J Med Chem. 1998 Sep 24;41(20):3821-30. DM8A23B RU https://pubmed.ncbi.nlm.nih.gov/9748357 DMMT65J DI DMMT65J DMMT65J DN N-benzyl-2-(5-nitro-1H-indol-3-yl)-2-oxoacetamide DMMT65J MI TT1MPAY DMMT65J MN GABA(A) receptor alpha-1 (GABRA1) DMMT65J MT DTT DMMT65J MA Inhibitor DMMT65J RN Novel N-substituted indol-3-ylglyoxylamides probing the LDi and L1/L2 lipophilic regions of the benzodiazepine receptor site in search for subtype-... J Med Chem. 2007 Apr 5;50(7):1627-34. DMMT65J RU https://pubmed.ncbi.nlm.nih.gov/17335185 DMMT65J DI DMMT65J DMMT65J DN N-benzyl-2-(5-nitro-1H-indol-3-yl)-2-oxoacetamide DMMT65J MI TTZA1NY DMMT65J MN GABA(A) receptor beta-2 (GABRB2) DMMT65J MT DTT DMMT65J MA Inhibitor DMMT65J RN Novel N-substituted indol-3-ylglyoxylamides probing the LDi and L1/L2 lipophilic regions of the benzodiazepine receptor site in search for subtype-... J Med Chem. 2007 Apr 5;50(7):1627-34. DMMT65J RU https://pubmed.ncbi.nlm.nih.gov/17335185 DMMT65J DI DMMT65J DMMT65J DN N-benzyl-2-(5-nitro-1H-indol-3-yl)-2-oxoacetamide DMMT65J MI TT06RH5 DMMT65J MN GABA(A) receptor gamma-2 (GABRG2) DMMT65J MT DTT DMMT65J MA Inhibitor DMMT65J RN Novel N-substituted indol-3-ylglyoxylamides probing the LDi and L1/L2 lipophilic regions of the benzodiazepine receptor site in search for subtype-... J Med Chem. 2007 Apr 5;50(7):1627-34. DMMT65J RU https://pubmed.ncbi.nlm.nih.gov/17335185 DM0ZXBQ DI DM0ZXBQ DM0ZXBQ DN N-benzyl-2-(pyrrolidin-1-yl)pyrimidin-4-amine DM0ZXBQ MI TT1RS9F DM0ZXBQ MN Acetylcholinesterase (AChE) DM0ZXBQ MT DTT DM0ZXBQ MA Inhibitor DM0ZXBQ RN Design, synthesis and evaluation of 2,4-disubstituted pyrimidines as cholinesterase inhibitors. Bioorg Med Chem Lett. 2010 Jun 15;20(12):3606-9. DM0ZXBQ RU https://pubmed.ncbi.nlm.nih.gov/20472431 DM3C0P2 DI DM3C0P2 DM3C0P2 DN N-Benzyl-2-(toluene-4-sulfonylamino)-benzamide DM3C0P2 MI TTW0CMT DM3C0P2 MN Voltage-gated potassium channel Kv1.5 (KCNA5) DM3C0P2 MT DTT DM3C0P2 MA Inhibitor DM3C0P2 RN Pharmacophore-based search, synthesis, and biological evaluation of anthranilic amides as novel blockers of the Kv1.5 channel. Bioorg Med Chem Lett. 2004 Jun 7;14(11):2823-7. DM3C0P2 RU https://pubmed.ncbi.nlm.nih.gov/15125940 DMQCGFL DI DMQCGFL DMQCGFL DN N-benzyl-2-morpholinopyrimidin-4-amine DMQCGFL MI TT1RS9F DMQCGFL MN Acetylcholinesterase (AChE) DMQCGFL MT DTT DMQCGFL MA Inhibitor DMQCGFL RN Design, synthesis and evaluation of 2,4-disubstituted pyrimidines as cholinesterase inhibitors. Bioorg Med Chem Lett. 2010 Jun 15;20(12):3606-9. DMQCGFL RU https://pubmed.ncbi.nlm.nih.gov/20472431 DMJ29MN DI DMJ29MN DMJ29MN DN N-benzyl-2-oxo-2H-chromene-3-carboxamide DMJ29MN MI TTGP7BY DMJ29MN MN Monoamine oxidase type B (MAO-B) DMJ29MN MT DTT DMJ29MN MA Inhibitor DMJ29MN RN Synthesis, molecular modeling, and selective inhibitory activity against human monoamine oxidases of 3-carboxamido-7-substituted coumarins. J Med Chem. 2009 Apr 9;52(7):1935-42. DMJ29MN RU https://pubmed.ncbi.nlm.nih.gov/19267475 DMRJMGK DI DMRJMGK DMRJMGK DN N-benzyl-2-thiomorpholinopyrimidin-4-amine DMRJMGK MI TT1RS9F DMRJMGK MN Acetylcholinesterase (AChE) DMRJMGK MT DTT DMRJMGK MA Inhibitor DMRJMGK RN Design, synthesis and evaluation of 2,4-disubstituted pyrimidines as cholinesterase inhibitors. Bioorg Med Chem Lett. 2010 Jun 15;20(12):3606-9. DMRJMGK RU https://pubmed.ncbi.nlm.nih.gov/20472431 DMRJMGK DI DMRJMGK DMRJMGK DN N-benzyl-2-thiomorpholinopyrimidin-4-amine DMRJMGK MI TTEB0GD DMRJMGK MN Cholinesterase (BCHE) DMRJMGK MT DTT DMRJMGK MA Inhibitor DMRJMGK RN Design, synthesis and evaluation of 2,4-disubstituted pyrimidines as cholinesterase inhibitors. Bioorg Med Chem Lett. 2010 Jun 15;20(12):3606-9. DMRJMGK RU https://pubmed.ncbi.nlm.nih.gov/20472431 DMUD85N DI DMUD85N DMUD85N DN N-Benzyl-4-(2,5-dihydroxy-benzylamino)-benzamide DMUD85N MI TTOU65C DMUD85N MN Tyrosine-protein kinase SYK (SYK) DMUD85N MT DTT DMUD85N MA Inhibitor DMUD85N RN Design, synthesis, and biological evaluation of a series of lavendustin A analogues that inhibit EGFR and Syk tyrosine kinases, as well as tubulin ... J Med Chem. 2001 Feb 1;44(3):441-52. DMUD85N RU https://pubmed.ncbi.nlm.nih.gov/11462983 DMCJWQT DI DMCJWQT DMCJWQT DN N-Benzyl-4-(2-diphenyl)-1-piperazinehexanamide DMCJWQT MI TTSQIFT DMCJWQT MN 5-HT 1A receptor (HTR1A) DMCJWQT MT DTT DMCJWQT MA Inhibitor DMCJWQT RN Structural modifications of N-(1,2,3,4-tetrahydronaphthalen-1-yl)-4-aryl-1-piperazinehexanamides: influence on lipophilicity and 5-HT7 receptor act... J Med Chem. 2008 Sep 25;51(18):5813-22. DMCJWQT RU https://pubmed.ncbi.nlm.nih.gov/18800769 DMCJWQT DI DMCJWQT DMCJWQT DN N-Benzyl-4-(2-diphenyl)-1-piperazinehexanamide DMCJWQT MI TTEX248 DMCJWQT MN Dopamine D2 receptor (D2R) DMCJWQT MT DTT DMCJWQT MA Inhibitor DMCJWQT RN Structural modifications of N-(1,2,3,4-tetrahydronaphthalen-1-yl)-4-aryl-1-piperazinehexanamides: influence on lipophilicity and 5-HT7 receptor act... J Med Chem. 2008 Sep 25;51(18):5813-22. DMCJWQT RU https://pubmed.ncbi.nlm.nih.gov/18800769 DMUNL5Q DI DMUNL5Q DMUNL5Q DN N-benzyl-4-bromo-3-(morpholinosulfonyl)benzamide DMUNL5Q MI TTMSFAW DMUNL5Q MN Cannabinoid receptor 2 (CB2) DMUNL5Q MT DTT DMUNL5Q MA Inhibitor DMUNL5Q RN CB2 selective sulfamoyl benzamides: optimization of the amide functionality. Bioorg Med Chem Lett. 2009 Jan 15;19(2):309-13. DMUNL5Q RU https://pubmed.ncbi.nlm.nih.gov/19091565 DMUFR62 DI DMUFR62 DMUFR62 DN N-benzyl-4-cyclopentylpiperazine-1-carboxamide DMUFR62 MI TT9JNIC DMUFR62 MN Histamine H3 receptor (H3R) DMUFR62 MT DTT DMUFR62 MA Inhibitor DMUFR62 RN Ureas with histamine H3-antagonist receptor activity--a new scaffold discovered by lead-hopping from cinnamic acid amides. Bioorg Med Chem Lett. 2006 Oct 15;16(20):5303-8. DMUFR62 RU https://pubmed.ncbi.nlm.nih.gov/16908150 DM5TPEJ DI DM5TPEJ DM5TPEJ DN N-benzyl-4-hydroxy-N-phenylbenzenesulfonamide DM5TPEJ MI TTZAYWL DM5TPEJ MN Estrogen receptor (ESR) DM5TPEJ MT DTT DM5TPEJ MA Inhibitor DM5TPEJ RN Substituted 4-hydroxyphenyl sulfonamides as pathway-selective estrogen receptor ligands. Bioorg Med Chem Lett. 2006 Feb 15;16(4):854-8. DM5TPEJ RU https://pubmed.ncbi.nlm.nih.gov/16300947 DMCIJU0 DI DMCIJU0 DMCIJU0 DN N-Benzyl-4-Sulfamoyl-Benzamide DMCIJU0 MI TTANPDJ DMCIJU0 MN Carbonic anhydrase II (CA-II) DMCIJU0 MT DTT DMCIJU0 MA Inhibitor DMCIJU0 RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMCIJU0 RU https://pubmed.ncbi.nlm.nih.gov/17139284 DM2XLHY DI DM2XLHY DM2XLHY DN N-benzyl-5-(4-chlorophenyl)nicotinamide DM2XLHY MI TT90XZ8 DM2XLHY MN Voltage-gated sodium channel alpha Nav1.8 (SCN10A) DM2XLHY MT DTT DM2XLHY MA Inhibitor DM2XLHY RN Subtype-selective Na(v)1.8 sodium channel blockers: identification of potent, orally active nicotinamide derivatives. Bioorg Med Chem Lett. 2010 Nov 15;20(22):6812-5. DM2XLHY RU https://pubmed.ncbi.nlm.nih.gov/20855211 DM7NHRV DI DM7NHRV DM7NHRV DN N-benzyl-6-(3,3,3-trifluoropropoxy)nicotinamide DM7NHRV MI TT7WVHI DM7NHRV MN Soluble epoxide hydrolase (EPHX2) DM7NHRV MT DTT DM7NHRV MA Inhibitor DM7NHRV RN Design and synthesis of substituted nicotinamides as inhibitors of soluble epoxide hydrolase. Bioorg Med Chem Lett. 2009 Oct 15;19(20):5864-8. DM7NHRV RU https://pubmed.ncbi.nlm.nih.gov/19758802 DMDRE64 DI DMDRE64 DMDRE64 DN N-benzyl-9-oxo-9,10-dihydroacridine-3-carboxamide DMDRE64 MI TTTB4UP DMDRE64 MN Inosine-5'-monophosphate dehydrogenase 2 (IMPDH2) DMDRE64 MT DTT DMDRE64 MA Inhibitor DMDRE64 RN Acridone-based inhibitors of inosine 5'-monophosphate dehydrogenase: discovery and SAR leading to the identification of N-(2-(6-(4-ethylpiperazin-1... J Med Chem. 2007 Jul 26;50(15):3730-42. DMDRE64 RU https://pubmed.ncbi.nlm.nih.gov/17585753 DM26R4P DI DM26R4P DM26R4P DN N-benzylacetimidamide hydrobromide DM26R4P MI TTF10I9 DM26R4P MN Nitric-oxide synthase inducible (NOS2) DM26R4P MT DTT DM26R4P MA Inhibitor DM26R4P RN N-Substituted acetamidines and 2-methylimidazole derivatives as selective inhibitors of neuronal nitric oxide synthase. Bioorg Med Chem Lett. 2010 Nov 15;20(22):6495-9. DM26R4P RU https://pubmed.ncbi.nlm.nih.gov/20933416 DMNPS4R DI DMNPS4R DMNPS4R DN N-Benzyl-ETAV DMNPS4R MI TT9PB26 DMNPS4R MN Presynaptic density protein 95 (DLG4) DMNPS4R MT DTT DMNPS4R MA Inhibitor DMNPS4R RN Modified peptides as potent inhibitors of the postsynaptic density-95/N-methyl-D-aspartate receptor interaction. J Med Chem. 2008 Oct 23;51(20):6450-9. DMNPS4R RU https://pubmed.ncbi.nlm.nih.gov/18811137 DMDZ5XI DI DMDZ5XI DMDZ5XI DN N-Benzylmethylphenidate DMDZ5XI MI TTVBI8W DMDZ5XI MN Dopamine transporter (DAT) DMDZ5XI MT DTT DMDZ5XI MA Inhibitor DMDZ5XI RN Quantitative structure-activity relationship studies of threo-methylphenidate analogs. Bioorg Med Chem. 2010 Oct 15;18(20):7221-38. DMDZ5XI RU https://pubmed.ncbi.nlm.nih.gov/20846865 DM0NJAL DI DM0NJAL DM0NJAL DN N-Benzyl-N-(1H-indol-2-ylmethyl)-N-methylamine DM0NJAL MI TT3WG5C DM0NJAL MN Monoamine oxidase type A (MAO-A) DM0NJAL MT DTT DM0NJAL MA Inhibitor DM0NJAL RN Synthesis, structure-activity relationships and molecular modeling studies of new indole inhibitors of monoamine oxidases A and B. Bioorg Med Chem. 2008 Nov 15;16(22):9729-40. DM0NJAL RU https://pubmed.ncbi.nlm.nih.gov/18951803 DM0NJAL DI DM0NJAL DM0NJAL DN N-Benzyl-N-(1H-indol-2-ylmethyl)-N-methylamine DM0NJAL MI TTGP7BY DM0NJAL MN Monoamine oxidase type B (MAO-B) DM0NJAL MT DTT DM0NJAL MA Inhibitor DM0NJAL RN Synthesis, structure-activity relationships and molecular modeling studies of new indole inhibitors of monoamine oxidases A and B. Bioorg Med Chem. 2008 Nov 15;16(22):9729-40. DM0NJAL RU https://pubmed.ncbi.nlm.nih.gov/18951803 DMT2GSI DI DMT2GSI DMT2GSI DN N-benzyl-N-(phenylsulfonyl)benzamide DMT2GSI MI TTN7BL9 DMT2GSI MN Corticosteroid 11-beta-dehydrogenase 1 (HSD11B1) DMT2GSI MT DTT DMT2GSI MA Inhibitor DMT2GSI RN beta-Keto sulfones as inhibitors of 11beta-hydroxysteroid dehydrogenase type I and the mechanism of action. Bioorg Med Chem. 2007 Jul 1;15(13):4396-405. DMT2GSI RU https://pubmed.ncbi.nlm.nih.gov/17490884 DM6QK7E DI DM6QK7E DM6QK7E DN N-benzyl-N-isobutylpiperidin-4-amine DM6QK7E MI TTAWNKZ DM6QK7E MN Norepinephrine transporter (NET) DM6QK7E MT DTT DM6QK7E MA Inhibitor DM6QK7E RN N-Alkyl-N-arylmethylpiperidin-4-amines: novel dual inhibitors of serotonin and norepinephrine reuptake. Bioorg Med Chem Lett. 2006 May 15;16(10):2714-8. DM6QK7E RU https://pubmed.ncbi.nlm.nih.gov/16497500 DM6QK7E DI DM6QK7E DM6QK7E DN N-benzyl-N-isobutylpiperidin-4-amine DM6QK7E MI TT3ROYC DM6QK7E MN Serotonin transporter (SERT) DM6QK7E MT DTT DM6QK7E MA Inhibitor DM6QK7E RN N-Alkyl-N-arylmethylpiperidin-4-amines: novel dual inhibitors of serotonin and norepinephrine reuptake. Bioorg Med Chem Lett. 2006 May 15;16(10):2714-8. DM6QK7E RU https://pubmed.ncbi.nlm.nih.gov/16497500 DMVEZH1 DI DMVEZH1 DMVEZH1 DN N-benzylnorlitebamine DMVEZH1 MI TT1RS9F DMVEZH1 MN Acetylcholinesterase (AChE) DMVEZH1 MT DTT DMVEZH1 MA Inhibitor DMVEZH1 RN Litebamine N-homologues: preparation and anti-acetylcholinesterase activity. J Nat Prod. 1998 Jan;61(1):46-50. DMVEZH1 RU https://pubmed.ncbi.nlm.nih.gov/9461651 DM7S5Y4 DI DM7S5Y4 DM7S5Y4 DN NBI-59159 DM7S5Y4 MI TTG2A6F DM7S5Y4 MN Excitatory amino acid transporter 3 (SLC1A1) DM7S5Y4 MT DTT DM7S5Y4 MA Inhibitor DM7S5Y4 RN Ligands targeting the excitatory amino acid transporters (EAATs). Curr Top Med Chem. 2006;6(17):1897-906. DM7S5Y4 RU https://pubmed.ncbi.nlm.nih.gov/17017964 DMURC6X DI DMURC6X DMURC6X DN NBI-74330 DMURC6X MI TT1UCIJ DMURC6X MN C-X-C chemokine receptor type 3 (CXCR3) DMURC6X MT DTT DMURC6X MA Antagonist DMURC6X RN Pharmacological characterization of CXC chemokine receptor 3 ligands and a small molecule antagonist. J Pharmacol Exp Ther. 2005 Jun;313(3):1263-71. DMURC6X RU https://pubmed.ncbi.nlm.nih.gov/15761110 DMJF9VA DI DMJF9VA DMJF9VA DN N-biphenyl-3-ylmethyl-N'-hydroxy-malonamide DMJF9VA MI TTPHMWB DMJF9VA MN Aminopeptidase N (ANPEP) DMJF9VA MT DTT DMJF9VA MA Inhibitor DMJF9VA RN Novel selective inhibitors of the zinc plasmodial aminopeptidase PfA-M1 as potential antimalarial agents. J Med Chem. 2007 Mar 22;50(6):1322-34. DMJF9VA RU https://pubmed.ncbi.nlm.nih.gov/17326615 DMWSDZ9 DI DMWSDZ9 DMWSDZ9 DN N-bis-(3-phenyl-propyl)9-oxo-fluorene-2,7-diamide DMWSDZ9 MI TT39J16 DMWSDZ9 MN Poly [ADP-ribose] glycohydrolase (PARG) DMWSDZ9 MT DTT DMWSDZ9 MA Inhibitor DMWSDZ9 RN Post-treatment with a novel PARG inhibitor reduces infarct in cerebral ischemia in the rat. Brain Res. 2003 Jul 18;978(1-2):99-103. DMWSDZ9 RU https://pubmed.ncbi.nlm.nih.gov/12834903 DMVF420 DI DMVF420 DMVF420 DN NBTGR DMVF420 MI TTLXAKE DMVF420 MN Solute carrier family 29 member 1 (SLC29A1) DMVF420 MT DTT DMVF420 MA Inhibitor DMVF420 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1117). DMVF420 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1117 DMAQT6S DI DMAQT6S DMAQT6S DN N-Butyl 2beta-hydroxyolean-12-en-28-oate DMAQT6S MI TTZHY6R DMAQT6S MN Glycogen phosphorylase muscle form (GP) DMAQT6S MT DTT DMAQT6S MA Inhibitor DMAQT6S RN Synthesis of 3-deoxypentacyclic triterpene derivatives as inhibitors of glycogen phosphorylase. J Nat Prod. 2009 Aug;72(8):1414-8. DMAQT6S RU https://pubmed.ncbi.nlm.nih.gov/19642687 DM157LQ DI DM157LQ DM157LQ DN N-butyl-2-(1H-indol-3-yl)-2-oxoacetamide DM157LQ MI TT1MPAY DM157LQ MN GABA(A) receptor alpha-1 (GABRA1) DM157LQ MT DTT DM157LQ MA Inhibitor DM157LQ RN Novel N-substituted indol-3-ylglyoxylamides probing the LDi and L1/L2 lipophilic regions of the benzodiazepine receptor site in search for subtype-... J Med Chem. 2007 Apr 5;50(7):1627-34. DM157LQ RU https://pubmed.ncbi.nlm.nih.gov/17335185 DM157LQ DI DM157LQ DM157LQ DN N-butyl-2-(1H-indol-3-yl)-2-oxoacetamide DM157LQ MI TTZA1NY DM157LQ MN GABA(A) receptor beta-2 (GABRB2) DM157LQ MT DTT DM157LQ MA Inhibitor DM157LQ RN Novel N-substituted indol-3-ylglyoxylamides probing the LDi and L1/L2 lipophilic regions of the benzodiazepine receptor site in search for subtype-... J Med Chem. 2007 Apr 5;50(7):1627-34. DM157LQ RU https://pubmed.ncbi.nlm.nih.gov/17335185 DM157LQ DI DM157LQ DM157LQ DN N-butyl-2-(1H-indol-3-yl)-2-oxoacetamide DM157LQ MI TT06RH5 DM157LQ MN GABA(A) receptor gamma-2 (GABRG2) DM157LQ MT DTT DM157LQ MA Inhibitor DM157LQ RN Novel N-substituted indol-3-ylglyoxylamides probing the LDi and L1/L2 lipophilic regions of the benzodiazepine receptor site in search for subtype-... J Med Chem. 2007 Apr 5;50(7):1627-34. DM157LQ RU https://pubmed.ncbi.nlm.nih.gov/17335185 DMH7Z4L DI DMH7Z4L DMH7Z4L DN N-butyl-2-(5-nitro-1H-indol-3-yl)-2-oxoacetamide DMH7Z4L MI TT1MPAY DMH7Z4L MN GABA(A) receptor alpha-1 (GABRA1) DMH7Z4L MT DTT DMH7Z4L MA Inhibitor DMH7Z4L RN Novel N-substituted indol-3-ylglyoxylamides probing the LDi and L1/L2 lipophilic regions of the benzodiazepine receptor site in search for subtype-... J Med Chem. 2007 Apr 5;50(7):1627-34. DMH7Z4L RU https://pubmed.ncbi.nlm.nih.gov/17335185 DMH7Z4L DI DMH7Z4L DMH7Z4L DN N-butyl-2-(5-nitro-1H-indol-3-yl)-2-oxoacetamide DMH7Z4L MI TTZA1NY DMH7Z4L MN GABA(A) receptor beta-2 (GABRB2) DMH7Z4L MT DTT DMH7Z4L MA Inhibitor DMH7Z4L RN Novel N-substituted indol-3-ylglyoxylamides probing the LDi and L1/L2 lipophilic regions of the benzodiazepine receptor site in search for subtype-... J Med Chem. 2007 Apr 5;50(7):1627-34. DMH7Z4L RU https://pubmed.ncbi.nlm.nih.gov/17335185 DMH7Z4L DI DMH7Z4L DMH7Z4L DN N-butyl-2-(5-nitro-1H-indol-3-yl)-2-oxoacetamide DMH7Z4L MI TT06RH5 DMH7Z4L MN GABA(A) receptor gamma-2 (GABRG2) DMH7Z4L MT DTT DMH7Z4L MA Inhibitor DMH7Z4L RN Novel N-substituted indol-3-ylglyoxylamides probing the LDi and L1/L2 lipophilic regions of the benzodiazepine receptor site in search for subtype-... J Med Chem. 2007 Apr 5;50(7):1627-34. DMH7Z4L RU https://pubmed.ncbi.nlm.nih.gov/17335185 DMH7Z4L DI DMH7Z4L DMH7Z4L DN N-butyl-2-(5-nitro-1H-indol-3-yl)-2-oxoacetamide DMH7Z4L MI TTNJYV2 DMH7Z4L MN Gamma-aminobutyric acid receptor (GAR) DMH7Z4L MT DTT DMH7Z4L MA Inhibitor DMH7Z4L RN Novel N-substituted indol-3-ylglyoxylamides probing the LDi and L1/L2 lipophilic regions of the benzodiazepine receptor site in search for subtype-... J Med Chem. 2007 Apr 5;50(7):1627-34. DMH7Z4L RU https://pubmed.ncbi.nlm.nih.gov/17335185 DMH5GW6 DI DMH5GW6 DMH5GW6 DN N-butyl-4-hydroxy-N-phenylbenzenesulfonamide DMH5GW6 MI TTZAYWL DMH5GW6 MN Estrogen receptor (ESR) DMH5GW6 MT DTT DMH5GW6 MA Inhibitor DMH5GW6 RN Substituted 4-hydroxyphenyl sulfonamides as pathway-selective estrogen receptor ligands. Bioorg Med Chem Lett. 2006 Feb 15;16(4):854-8. DMH5GW6 RU https://pubmed.ncbi.nlm.nih.gov/16300947 DMMI8X4 DI DMMI8X4 DMMI8X4 DN N-butyl-4-methyl-3,4-dihydroquinazolin-2-amine DMMI8X4 MI TTRUFDT DMMI8X4 MN 5-HT 5A receptor (HTR5A) DMMI8X4 MT DTT DMMI8X4 MA Inhibitor DMMI8X4 RN Cyclic guanidines as dual 5-HT5A/5-HT7 receptor ligands: optimising brain penetration. Bioorg Med Chem Lett. 2008 Jan 1;18(1):262-6. DMMI8X4 RU https://pubmed.ncbi.nlm.nih.gov/18023344 DMW7BZT DI DMW7BZT DMW7BZT DN N-Butylcarbamic Acid Biphenyl-3-yl Ester DMW7BZT MI TTDP1UC DMW7BZT MN Fatty acid amide hydrolase (FAAH) DMW7BZT MT DTT DMW7BZT MA Inhibitor DMW7BZT RN Synthesis and quantitative structure-activity relationship of fatty acid amide hydrolase inhibitors: modulation at the N-portion of biphenyl-3-yl a... J Med Chem. 2008 Jun 26;51(12):3487-98. DMW7BZT RU https://pubmed.ncbi.nlm.nih.gov/18507372 DMY3HEF DI DMY3HEF DMY3HEF DN N-Butyl-ETAV DMY3HEF MI TT9PB26 DMY3HEF MN Presynaptic density protein 95 (DLG4) DMY3HEF MT DTT DMY3HEF MA Inhibitor DMY3HEF RN Modified peptides as potent inhibitors of the postsynaptic density-95/N-methyl-D-aspartate receptor interaction. J Med Chem. 2008 Oct 23;51(20):6450-9. DMY3HEF RU https://pubmed.ncbi.nlm.nih.gov/18811137 DMB06TA DI DMB06TA DMB06TA DN N-butylgalactonojirimycin DMB06TA MI TTPHEX3 DMB06TA MN Ceramide glucosyltransferase (UGCG) DMB06TA MT DTT DMB06TA MA Inhibitor DMB06TA RN Accumulation of glucosylceramide in murine testis, caused by inhibition of beta-glucosidase 2: implications for spermatogenesis. J Biol Chem. 2007 Nov 9;282(45):32655-64. DMB06TA RU https://pubmed.ncbi.nlm.nih.gov/17848577 DM8U70E DI DM8U70E DM8U70E DN N-Butyl-N'-(4-methyl-benzoyl)-guanidine DM8U70E MI TTZOVE0 DM8U70E MN Voltage-gated sodium channel alpha Nav1.5 (SCN5A) DM8U70E MT DTT DM8U70E MA Inhibitor DM8U70E RN Solution-phase, parallel synthesis and pharmacological evaluation of acylguanidine derivatives as potential sodium channel blockers. Bioorg Med Chem Lett. 2001 Dec 17;11(24):3151-5. DM8U70E RU https://pubmed.ncbi.nlm.nih.gov/11720863 DMKCX5N DI DMKCX5N DMKCX5N DN N-Butyl-N'-Hydroxyguanidine DMKCX5N MI TTZUFI5 DMKCX5N MN Nitric-oxide synthase brain (NOS1) DMKCX5N MT DTT DMKCX5N MA Inhibitor DMKCX5N RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMKCX5N RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMNFTO6 DI DMNFTO6 DMNFTO6 DN N-butylnorlitebamine DMNFTO6 MI TT1RS9F DMNFTO6 MN Acetylcholinesterase (AChE) DMNFTO6 MT DTT DMNFTO6 MA Inhibitor DMNFTO6 RN Litebamine N-homologues: preparation and anti-acetylcholinesterase activity. J Nat Prod. 1998 Jan;61(1):46-50. DMNFTO6 RU https://pubmed.ncbi.nlm.nih.gov/9461651 DM8STQA DI DM8STQA DM8STQA DN N-butylresorcinol DM8STQA MI TTULVH8 DM8STQA MN Tyrosinase (TYR) DM8STQA MT DTT DM8STQA MA Inhibitor DM8STQA RN Studies on depigmenting activities of dihydroxyl benzamide derivatives containing adamantane moiety. Bioorg Med Chem Lett. 2009 Mar 1;19(5):1532-3. DM8STQA RU https://pubmed.ncbi.nlm.nih.gov/19181523 DMJCYMW DI DMJCYMW DMJCYMW DN NC00075159 DMJCYMW MI TT8HGRW DMJCYMW MN Voltage-gated potassium channel Kv7.4 (KCNQ4) DMJCYMW MT DTT DMJCYMW MA Activator DMJCYMW RN Identification of novel KCNQ4 openers by a high-throughput fluorescence-based thallium flux assay. Anal Biochem. 2011 Nov 1;418(1):66-72. DMJCYMW RU https://pubmed.ncbi.nlm.nih.gov/21782781 DM6XGFE DI DM6XGFE DM6XGFE DN NC1153 DM6XGFE MI TTT7PJU DM6XGFE MN Janus kinase 3 (JAK-3) DM6XGFE MT DTT DM6XGFE MA Inhibitor DM6XGFE RN Immunotherapy for De Novo renal transplantation: what's in the pipeline Drugs. 2006;66(13):1665-84. DM6XGFE RU https://pubmed.ncbi.nlm.nih.gov/16978033 DMJKZUC DI DMJKZUC DMJKZUC DN NC-2100 DMJKZUC MI TTI12YJ DMJKZUC MN Mitochondrial uncoupling protein 1 (UCP1) DMJKZUC MT DTT DMJKZUC MA Inducer DMJKZUC RN A new thiazolidinedione, NC-2100, which is a weak PPAR-gamma activator, exhibits potent antidiabetic effects and induces uncoupling protein 1 in white adipose tissue of KKAy obese mice. Diabetes. 2000 May;49(5):759-67. DMJKZUC RU https://pubmed.ncbi.nlm.nih.gov/10905484 DMJKZUC DI DMJKZUC DMJKZUC DN NC-2100 DMJKZUC MI TTSC2YM DMJKZUC MN Mitochondrial uncoupling protein 2 (UCP2) DMJKZUC MT DTT DMJKZUC MA Inducer DMJKZUC RN A new thiazolidinedione, NC-2100, which is a weak PPAR-gamma activator, exhibits potent antidiabetic effects and induces uncoupling protein 1 in white adipose tissue of KKAy obese mice. Diabetes. 2000 May;49(5):759-67. DMJKZUC RU https://pubmed.ncbi.nlm.nih.gov/10905484 DM45MGZ DI DM45MGZ DM45MGZ DN NC-2500 DM45MGZ MI TT7RJY8 DM45MGZ MN Xanthine dehydrogenase/oxidase (XDH) DM45MGZ MT DTT DM45MGZ MA Inhibitor DM45MGZ RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2646). DM45MGZ RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2646 DMJ13TR DI DMJ13TR DMJ13TR DN N-Carbamoyl-L-Aspartate DMJ13TR MI TT09NOX DMJ13TR MN Plasmodium Dihydroorotase (Malaria dho) DMJ13TR MT DTT DMJ13TR MA Inhibitor DMJ13TR RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMJ13TR RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMX80JF DI DMX80JF DMX80JF DN N-Carboxymethionine DMX80JF MI TTU6BFZ DMX80JF MN Candida Thymidylate synthase (Candi TMP1) DMX80JF MT DTT DMX80JF MA Inhibitor DMX80JF RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMX80JF RU https://pubmed.ncbi.nlm.nih.gov/17139284 DME9U7Y DI DME9U7Y DME9U7Y DN N-Carboxymethyl-N-cyclopentyl-phthalamic acid DME9U7Y MI TTL69WB DME9U7Y MN Angiotensin-converting enzyme (ACE) DME9U7Y MT DTT DME9U7Y MA Inhibitor DME9U7Y RN Angiotensin converting enzyme inhibitors. (Mercaptoaroyl)amino acids. J Med Chem. 1985 Mar;28(3):328-32. DME9U7Y RU https://pubmed.ncbi.nlm.nih.gov/2983075 DM5KNCX DI DM5KNCX DM5KNCX DN N-cetylgallate DM5KNCX MI TTE14XG DM5KNCX MN Squalene monooxygenase (SQLE) DM5KNCX MT DTT DM5KNCX MA Inhibitor DM5KNCX RN Ellagitannins and hexahydroxydiphenoyl esters as inhibitors of vertebrate squalene epoxidase. J Nat Prod. 2001 Aug;64(8):1010-4. DM5KNCX RU https://pubmed.ncbi.nlm.nih.gov/11520216 DM0JCN2 DI DM0JCN2 DM0JCN2 DN NCFP DM0JCN2 MI TTHS256 DM0JCN2 MN Metabotropic glutamate receptor 5 (mGluR5) DM0JCN2 MT DTT DM0JCN2 MA Modulator (allosteric modulator) DM0JCN2 RN A novel metabotropic glutamate receptor 5 positive allosteric modulator acts at a unique site and confers stimulus bias to mGlu5 signaling. Mol Pharmacol. 2013 Apr;83(4):835-47. DM0JCN2 RU https://pubmed.ncbi.nlm.nih.gov/23348500 DMMRWJG DI DMMRWJG DMMRWJG DN NCG21 DMMRWJG MI TT08JVB DMMRWJG MN G-protein coupled receptor 120 (GPR120) DMMRWJG MT DTT DMMRWJG MA Agonist DMMRWJG RN Identification of G protein-coupled receptor 120-selective agonists derived from PPARgamma agonists. J Med Chem. 2008 Dec 11;51(23):7640-4. DMMRWJG RU https://pubmed.ncbi.nlm.nih.gov/19007110 DMY8RT9 DI DMY8RT9 DMY8RT9 DN NCGC00167772-01 DMY8RT9 MI TTTN5QW DMY8RT9 MN Serine/threonine-protein kinase pim-1 (PIM1) DMY8RT9 MT DTT DMY8RT9 MA Inhibitor DMY8RT9 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2158). DMY8RT9 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2158 DM6VEON DI DM6VEON DM6VEON DN N-chloromethyl-brucine DM6VEON MI TTOXS3C DM6VEON MN Muscarinic acetylcholine receptor (CHRM) DM6VEON MT DTT DM6VEON MA Modulator (allosteric modulator) DM6VEON RN Subtype-selective positive cooperative interactions between brucine analogues and acetylcholine at muscarinic receptors: radioligand binding studies. Mol Pharmacol. 1998 Mar;53(3):573-89. DM6VEON RU https://pubmed.ncbi.nlm.nih.gov/9495826 DM6VEON DI DM6VEON DM6VEON DN N-chloromethyl-brucine DM6VEON MI TTQ13Z5 DM6VEON MN Muscarinic acetylcholine receptor M3 (CHRM3) DM6VEON MT DTT DM6VEON MA Modulator (allosteric modulator) DM6VEON RN Subtype-selective positive cooperative interactions between brucine analogues and acetylcholine at muscarinic receptors: radioligand binding studies. Mol Pharmacol. 1998 Mar;53(3):573-89. DM6VEON RU https://pubmed.ncbi.nlm.nih.gov/9495826 DMTCBLS DI DMTCBLS DMTCBLS DN NCI-159878 DMTCBLS MI TTLUQ8E DMTCBLS MN Hormone sensitive lipase (LIPE) DMTCBLS MT DTT DMTCBLS MA Inhibitor DMTCBLS RN Combining ligand-based pharmacophore modeling, quantitative structure-activity relationship analysis and in silico screening for the discovery of n... J Med Chem. 2008 Oct 23;51(20):6478-94. DMTCBLS RU https://pubmed.ncbi.nlm.nih.gov/18808096 DM9C7GP DI DM9C7GP DM9C7GP DN NCI-58425 DM9C7GP MI TTLUQ8E DM9C7GP MN Hormone sensitive lipase (LIPE) DM9C7GP MT DTT DM9C7GP MA Inhibitor DM9C7GP RN Combining ligand-based pharmacophore modeling, quantitative structure-activity relationship analysis and in silico screening for the discovery of n... J Med Chem. 2008 Oct 23;51(20):6478-94. DM9C7GP RU https://pubmed.ncbi.nlm.nih.gov/18808096 DMH1BVG DI DMH1BVG DMH1BVG DN NCL-1 DMH1BVG MI TTNR0UQ DMH1BVG MN Lysine-specific histone demethylase 1 (LSD) DMH1BVG MT DTT DMH1BVG MA Inhibitor DMH1BVG RN Synthesis and biological activity of optically active NCL-1, a lysine-specific demethylase 1 selective inhibitor. Bioorg Med Chem. 2011 Jun 15;19(12):3702-8. DMH1BVG RU https://pubmed.ncbi.nlm.nih.gov/21227703 DM1K64F DI DM1K64F DM1K64F DN N-CPM[D-Pro-10]Dyn A-(1-11) DM1K64F MI TTQW87Y DM1K64F MN Opioid receptor kappa (OPRK1) DM1K64F MT DTT DM1K64F MA Inhibitor DM1K64F RN Synthesis and opioid activity of [D-Pro10]dynorphin A-(1-11) analogues with N-terminal alkyl substitution. J Med Chem. 1997 Aug 15;40(17):2733-9. DM1K64F RU https://pubmed.ncbi.nlm.nih.gov/9276018 DM09UFT DI DM09UFT DM09UFT DN NCT-400 DM09UFT MI TTKWM86 DM09UFT MN Opioid receptor mu (MOP) DM09UFT MT DTT DM09UFT MA Modulator DM09UFT RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 319). DM09UFT RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=319 DM1FOSP DI DM1FOSP DM1FOSP DN NCX-1047 DM1FOSP MI TTPNQAC DM1FOSP MN Estrogen-related receptor-alpha (ESRRA) DM1FOSP MT DTT DM1FOSP MA Modulator DM1FOSP RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 622). DM1FOSP RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=622 DMUHXRA DI DMUHXRA DMUHXRA DN NCX-1067 DMUHXRA MI TTPADOQ DMUHXRA MN HMG-CoA reductase (HMGCR) DMUHXRA MT DTT DMUHXRA MA Modulator DMUHXRA RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 639). DMUHXRA RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=639 DMYBWXR DI DMYBWXR DMYBWXR DN NCX-125 DMYBWXR MI TTT2ZAR DMYBWXR MN Prostaglandin F2-alpha receptor (PTGFR) DMYBWXR MT DTT DMYBWXR MA Modulator DMYBWXR RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 344). DMYBWXR RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=344 DM5T23S DI DM5T23S DM5T23S DN N-Cyclobutyl-1'H-phenothiazine-1'-carboxamide DM5T23S MI TTEB0GD DM5T23S MN Cholinesterase (BCHE) DM5T23S MT DTT DM5T23S MA Inhibitor DM5T23S RN Differential binding of phenothiazine urea derivatives to wild-type human cholinesterases and butyrylcholinesterase mutants. Bioorg Med Chem. 2010 Mar 15;18(6):2232-2244. DM5T23S RU https://pubmed.ncbi.nlm.nih.gov/20181484 DM1GTVW DI DM1GTVW DM1GTVW DN N-cyclobutyl-N-(piperidin-4-yl)-2-naphthamide DM1GTVW MI TT3ROYC DM1GTVW MN Serotonin transporter (SERT) DM1GTVW MT DTT DM1GTVW MA Inhibitor DM1GTVW RN Bioorg Med Chem Lett. 2009 Oct 15;19(20):5893-7. Epub 2009 Aug 21.Design and optimisation of selective serotonin re-uptake inhibitors with high synthetic accessibility: part 2. DM1GTVW RU https://pubmed.ncbi.nlm.nih.gov/19740658 DMMW8J1 DI DMMW8J1 DMMW8J1 DN N-Cyclohexyl-1'H-phenothiazine-1'-carboxamide DMMW8J1 MI TTEB0GD DMMW8J1 MN Cholinesterase (BCHE) DMMW8J1 MT DTT DMMW8J1 MA Inhibitor DMMW8J1 RN Differential binding of phenothiazine urea derivatives to wild-type human cholinesterases and butyrylcholinesterase mutants. Bioorg Med Chem. 2010 Mar 15;18(6):2232-2244. DMMW8J1 RU https://pubmed.ncbi.nlm.nih.gov/20181484 DM8HS0B DI DM8HS0B DM8HS0B DN N-Cyclohexyl-2-(4-methoxy-phenyl)-acetamide DM8HS0B MI TT7WVHI DM8HS0B MN Soluble epoxide hydrolase (EPHX2) DM8HS0B MT DTT DM8HS0B MA Inhibitor DM8HS0B RN Optimization of amide-based inhibitors of soluble epoxide hydrolase with improved water solubility. J Med Chem. 2005 May 19;48(10):3621-9. DM8HS0B RU https://pubmed.ncbi.nlm.nih.gov/15887969 DMRA548 DI DMRA548 DMRA548 DN N-cyclohexyl-2-oxo-2H-chromene-3-carboxamide DMRA548 MI TTGP7BY DMRA548 MN Monoamine oxidase type B (MAO-B) DMRA548 MT DTT DMRA548 MA Inhibitor DMRA548 RN Synthesis, molecular modeling, and selective inhibitory activity against human monoamine oxidases of 3-carboxamido-7-substituted coumarins. J Med Chem. 2009 Apr 9;52(7):1935-42. DMRA548 RU https://pubmed.ncbi.nlm.nih.gov/19267475 DM15MQT DI DM15MQT DM15MQT DN N-Cyclohexyl-2-phenyl-acetamide DM15MQT MI TT7WVHI DM15MQT MN Soluble epoxide hydrolase (EPHX2) DM15MQT MT DTT DM15MQT MA Inhibitor DM15MQT RN Optimization of amide-based inhibitors of soluble epoxide hydrolase with improved water solubility. J Med Chem. 2005 May 19;48(10):3621-9. DM15MQT RU https://pubmed.ncbi.nlm.nih.gov/15887969 DMCDBM5 DI DMCDBM5 DMCDBM5 DN N-cyclohexyl-4-hydroxy-N-phenylbenzenesulfonamide DMCDBM5 MI TTZAYWL DMCDBM5 MN Estrogen receptor (ESR) DMCDBM5 MT DTT DMCDBM5 MA Inhibitor DMCDBM5 RN Substituted 4-hydroxyphenyl sulfonamides as pathway-selective estrogen receptor ligands. Bioorg Med Chem Lett. 2006 Feb 15;16(4):854-8. DMCDBM5 RU https://pubmed.ncbi.nlm.nih.gov/16300947 DM2COR5 DI DM2COR5 DM2COR5 DN N-Cyclohexyl-4-phenyl-butyramide DM2COR5 MI TT7WVHI DM2COR5 MN Soluble epoxide hydrolase (EPHX2) DM2COR5 MT DTT DM2COR5 MA Inhibitor DM2COR5 RN Optimization of amide-based inhibitors of soluble epoxide hydrolase with improved water solubility. J Med Chem. 2005 May 19;48(10):3621-9. DM2COR5 RU https://pubmed.ncbi.nlm.nih.gov/15887969 DMCH5M1 DI DMCH5M1 DMCH5M1 DN N-Cyclohexylethyl-ETAV DMCH5M1 MI TT9PB26 DMCH5M1 MN Presynaptic density protein 95 (DLG4) DMCH5M1 MT DTT DMCH5M1 MA Inhibitor DMCH5M1 RN Modified peptides as potent inhibitors of the postsynaptic density-95/N-methyl-D-aspartate receptor interaction. J Med Chem. 2008 Oct 23;51(20):6450-9. DMCH5M1 RU https://pubmed.ncbi.nlm.nih.gov/18811137 DMIC8Z6 DI DMIC8Z6 DMIC8Z6 DN N-Cyclohexylmethyl-ETAV DMIC8Z6 MI TT9PB26 DMIC8Z6 MN Presynaptic density protein 95 (DLG4) DMIC8Z6 MT DTT DMIC8Z6 MA Inhibitor DMIC8Z6 RN Modified peptides as potent inhibitors of the postsynaptic density-95/N-methyl-D-aspartate receptor interaction. J Med Chem. 2008 Oct 23;51(20):6450-9. DMIC8Z6 RU https://pubmed.ncbi.nlm.nih.gov/18811137 DMPSYRW DI DMPSYRW DMPSYRW DN N-Cyclohexyl-N'-(4-Iodophenyl)Urea DMPSYRW MI TT7WVHI DMPSYRW MN Soluble epoxide hydrolase (EPHX2) DMPSYRW MT DTT DMPSYRW MA Inhibitor DMPSYRW RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMPSYRW RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMYF243 DI DMYF243 DMYF243 DN N-Cyclohexyl-N'-(Propyl)Phenyl Urea DMYF243 MI TT7WVHI DMYF243 MN Soluble epoxide hydrolase (EPHX2) DMYF243 MT DTT DMYF243 MA Inhibitor DMYF243 RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DMYF243 RU https://pubmed.ncbi.nlm.nih.gov/10592235 DM17G82 DI DM17G82 DM17G82 DN N-Cyclohexyl-N'-Decylurea DM17G82 MI TT7WVHI DM17G82 MN Soluble epoxide hydrolase (EPHX2) DM17G82 MT DTT DM17G82 MA Inhibitor DM17G82 RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DM17G82 RU https://pubmed.ncbi.nlm.nih.gov/10592235 DMJ0T3W DI DMJ0T3W DMJ0T3W DN N-cyclohexylquinazolin-4-amine DMJ0T3W MI TTVBPDM DMJ0T3W MN Metabotropic glutamate receptor 1 (mGluR1) DMJ0T3W MT DTT DMJ0T3W MA Inhibitor DMJ0T3W RN In vitro and in vivo SAR of pyrido[3,4-d]pyramid-4-ylamine based mGluR1 antagonists. Bioorg Med Chem Lett. 2009 Apr 15;19(8):2190-4. DMJ0T3W RU https://pubmed.ncbi.nlm.nih.gov/19289283 DMJY2PA DI DMJY2PA DMJY2PA DN N-cyclohexylquinolin-4-amine DMJY2PA MI TTVBPDM DMJY2PA MN Metabotropic glutamate receptor 1 (mGluR1) DMJY2PA MT DTT DMJY2PA MA Inhibitor DMJY2PA RN In vitro and in vivo SAR of pyrido[3,4-d]pyramid-4-ylamine based mGluR1 antagonists. Bioorg Med Chem Lett. 2009 Apr 15;19(8):2190-4. DMJY2PA RU https://pubmed.ncbi.nlm.nih.gov/19289283 DM0KDSA DI DM0KDSA DM0KDSA DN N-Cyclopentyl-1'H-phenothiazine-1'-carboxamide DM0KDSA MI TTEB0GD DM0KDSA MN Cholinesterase (BCHE) DM0KDSA MT DTT DM0KDSA MA Inhibitor DM0KDSA RN Differential binding of phenothiazine urea derivatives to wild-type human cholinesterases and butyrylcholinesterase mutants. Bioorg Med Chem. 2010 Mar 15;18(6):2232-2244. DM0KDSA RU https://pubmed.ncbi.nlm.nih.gov/20181484 DMDPKCM DI DMDPKCM DMDPKCM DN N-cyclopentyl-6-(2-phenylethynyl)nicotinamide DMDPKCM MI TTHS256 DMDPKCM MN Metabotropic glutamate receptor 5 (mGluR5) DMDPKCM MT DTT DMDPKCM MA Inhibitor DMDPKCM RN Discovery of a potent and brain penetrant mGluR5 positive allosteric modulator. Bioorg Med Chem Lett. 2009 Jun 15;19(12):3275-8. DMDPKCM RU https://pubmed.ncbi.nlm.nih.gov/19443216 DMMODRE DI DMMODRE DMMODRE DN ND-2110 DMMODRE MI TTKFVXR DMMODRE MN Renal carcinoma antigen NY-REN-64 (IRAK-4) DMMODRE MT DTT DMMODRE MA Inhibitor DMMODRE RN Recent advances in the discovery of small molecule inhibitors of interleukin-1 receptor-associated kinase 4 (IRAK4) as a therapeutic target for inflammation and oncology disorders. J Med Chem. 2015 Jan 8;58(1):96-110. DMMODRE RU https://pubmed.ncbi.nlm.nih.gov/25479567 DMH7GLE DI DMH7GLE DMH7GLE DN ND-2158 DMH7GLE MI TTKFVXR DMH7GLE MN Renal carcinoma antigen NY-REN-64 (IRAK-4) DMH7GLE MT DTT DMH7GLE MA Inhibitor DMH7GLE RN Recent advances in the discovery of small molecule inhibitors of interleukin-1 receptor-associated kinase 4 (IRAK4) as a therapeutic target for inflammation and oncology disorders. J Med Chem. 2015 Jan 8;58(1):96-110. DMH7GLE RU https://pubmed.ncbi.nlm.nih.gov/25479567 DMT0NQS DI DMT0NQS DMT0NQS DN ND-401 DMT0NQS MI TTBID49 DMT0NQS MN C-X-C chemokine receptor type 4 (CXCR4) DMT0NQS MT DTT DMT0NQS MA Inhibitor DMT0NQS RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 71). DMT0NQS RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=71 DM7NJI2 DI DM7NJI2 DM7NJI2 DN NDC-1022 DM7NJI2 MI TTOM3J0 DM7NJI2 MN Estrogen receptor beta (ESR2) DM7NJI2 MT DTT DM7NJI2 MA Agonist DM7NJI2 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 621). DM7NJI2 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=621 DMBFC1U DI DMBFC1U DMBFC1U DN N-desalkylquetiapine DMBFC1U MI TTAWNKZ DMBFC1U MN Norepinephrine transporter (NET) DMBFC1U MT DTT DMBFC1U MA Inhibitor DMBFC1U RN N-desalkylquetiapine, a potent norepinephrine reuptake inhibitor and partial 5-HT1A agonist, as a putative mediator of quetiapine's antidepressant ... Neuropsychopharmacology. 2008 Sep;33(10):2303-12. DMBFC1U RU https://pubmed.ncbi.nlm.nih.gov/18059438 DMV5RZM DI DMV5RZM DMV5RZM DN N-dodecylgallate DMV5RZM MI TTE14XG DMV5RZM MN Squalene monooxygenase (SQLE) DMV5RZM MT DTT DMV5RZM MA Inhibitor DMV5RZM RN Ellagitannins and hexahydroxydiphenoyl esters as inhibitors of vertebrate squalene epoxidase. J Nat Prod. 2001 Aug;64(8):1010-4. DMV5RZM RU https://pubmed.ncbi.nlm.nih.gov/11520216 DMTMHW2 DI DMTMHW2 DMTMHW2 DN NDP-alpha-MSH DMTMHW2 MI TTD0CIQ DMTMHW2 MN Melanocortin receptor 4 (MC4R) DMTMHW2 MT DTT DMTMHW2 MA Inhibitor DMTMHW2 RN cis-4-(Piperazin-1-yl)-5,6,7a,8,9,10,11,11a-octahydrobenzofuro[2,3-h]quinazolin-2-amine (A-987306), a new histamine H4R antagonist that blocks pain... J Med Chem. 2008 Nov 27;51(22):7094-8. DMTMHW2 RU https://pubmed.ncbi.nlm.nih.gov/18983139 DMRV16G DI DMRV16G DMRV16G DN NDP-SYSMEHFRWGKPVG DMRV16G MI TTEOSZT DMRV16G MN Melanocortin receptor (MCR) DMRV16G MT DTT DMRV16G MA Inhibitor DMRV16G RN Discovery of a beta-MSH-derived MC-4R selective agonist. J Med Chem. 2005 May 5;48(9):3095-8. DMRV16G RU https://pubmed.ncbi.nlm.nih.gov/15857110 DMRV16G DI DMRV16G DMRV16G DN NDP-SYSMEHFRWGKPVG DMRV16G MI TT0MV2T DMRV16G MN Melanocortin receptor 1 (MC1R) DMRV16G MT DTT DMRV16G MA Inhibitor DMRV16G RN Discovery of a beta-MSH-derived MC-4R selective agonist. J Med Chem. 2005 May 5;48(9):3095-8. DMRV16G RU https://pubmed.ncbi.nlm.nih.gov/15857110 DMRV16G DI DMRV16G DMRV16G DN NDP-SYSMEHFRWGKPVG DMRV16G MI TTNI91K DMRV16G MN Melanocortin receptor 3 (MC3R) DMRV16G MT DTT DMRV16G MA Inhibitor DMRV16G RN Discovery of a beta-MSH-derived MC-4R selective agonist. J Med Chem. 2005 May 5;48(9):3095-8. DMRV16G RU https://pubmed.ncbi.nlm.nih.gov/15857110 DMRV16G DI DMRV16G DMRV16G DN NDP-SYSMEHFRWGKPVG DMRV16G MI TTD0CIQ DMRV16G MN Melanocortin receptor 4 (MC4R) DMRV16G MT DTT DMRV16G MA Inhibitor DMRV16G RN Discovery of a beta-MSH-derived MC-4R selective agonist. J Med Chem. 2005 May 5;48(9):3095-8. DMRV16G RU https://pubmed.ncbi.nlm.nih.gov/15857110 DMFKX7Z DI DMFKX7Z DMFKX7Z DN NDT9520492 DMFKX7Z MI TTHXFA1 DMFKX7Z MN C5a anaphylatoxin chemotactic receptor (C5AR1) DMFKX7Z MT DTT DMFKX7Z MA Antagonist DMFKX7Z RN Molecular characterization of the gerbil C5a receptor and identification of a transmembrane domain V amino acid that is crucial for small molecule ... J Biol Chem. 2005 Dec 9;280(49):40617-23. DMFKX7Z RU https://pubmed.ncbi.nlm.nih.gov/16230349 DMGSNU4 DI DMGSNU4 DMGSNU4 DN NE-10575 DMGSNU4 MI TTIKWV4 DMGSNU4 MN Geranyltranstransferase (FDPS) DMGSNU4 MT DTT DMGSNU4 MA Inhibitor DMGSNU4 RN Structure-activity relationships among the nitrogen containing bisphosphonates in clinical use and other analogues: time-dependent inhibition of hu... J Med Chem. 2008 Apr 10;51(7):2187-95. DMGSNU4 RU https://pubmed.ncbi.nlm.nih.gov/18327899 DMVESO2 DI DMVESO2 DMVESO2 DN NE10790 DMVESO2 MI TTIKWV4 DMVESO2 MN Geranyltranstransferase (FDPS) DMVESO2 MT DTT DMVESO2 MA Inhibitor DMVESO2 RN Structure-activity relationships among the nitrogen containing bisphosphonates in clinical use and other analogues: time-dependent inhibition of hu... J Med Chem. 2008 Apr 10;51(7):2187-95. DMVESO2 RU https://pubmed.ncbi.nlm.nih.gov/18327899 DMR92HV DI DMR92HV DMR92HV DN NE11808 DMR92HV MI TTIKWV4 DMR92HV MN Geranyltranstransferase (FDPS) DMR92HV MT DTT DMR92HV MA Inhibitor DMR92HV RN Structure-activity relationships among the nitrogen containing bisphosphonates in clinical use and other analogues: time-dependent inhibition of hu... J Med Chem. 2008 Apr 10;51(7):2187-95. DMR92HV RU https://pubmed.ncbi.nlm.nih.gov/18327899 DMILP0F DI DMILP0F DMILP0F DN NE-2 DMILP0F MI TTKWM86 DMILP0F MN Opioid receptor mu (MOP) DMILP0F MT DTT DMILP0F MA Agonist DMILP0F RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 319). DMILP0F RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=319 DM58O3I DI DM58O3I DM58O3I DN NE21650 DM58O3I MI TTIKWV4 DM58O3I MN Geranyltranstransferase (FDPS) DM58O3I MT DTT DM58O3I MA Inhibitor DM58O3I RN Identification of a bisphosphonate that inhibits isopentenyl diphosphate isomerase and farnesyl diphosphate synthase. Biochem Biophys Res Commun. 2002 Jan 18;290(2):869-73. DM58O3I RU https://pubmed.ncbi.nlm.nih.gov/11785983 DMVSRYH DI DMVSRYH DMVSRYH DN NE-28345 DMVSRYH MI TTMI6F5 DMVSRYH MN Transient receptor potential cation channel V1 (TRPV1) DMVSRYH MT DTT DMVSRYH MA Modulator DMVSRYH RN The ChEMBL database in 2017. Nucleic Acids Res. 2017 Jan 4;45(D1):D945-D954. DMVSRYH RU https://www.ncbi.nlm.nih.gov/pubmed/27899562 DM28ZPT DI DM28ZPT DM28ZPT DN NE58018 DM28ZPT MI TTIKWV4 DM28ZPT MN Geranyltranstransferase (FDPS) DM28ZPT MT DTT DM28ZPT MA Inhibitor DM28ZPT RN Structure-activity relationships among the nitrogen containing bisphosphonates in clinical use and other analogues: time-dependent inhibition of hu... J Med Chem. 2008 Apr 10;51(7):2187-95. DM28ZPT RU https://pubmed.ncbi.nlm.nih.gov/18327899 DMU4I8R DI DMU4I8R DMU4I8R DN NE58027 DMU4I8R MI TTIKWV4 DMU4I8R MN Geranyltranstransferase (FDPS) DMU4I8R MT DTT DMU4I8R MA Inhibitor DMU4I8R RN Structure-activity relationships among the nitrogen containing bisphosphonates in clinical use and other analogues: time-dependent inhibition of hu... J Med Chem. 2008 Apr 10;51(7):2187-95. DMU4I8R RU https://pubmed.ncbi.nlm.nih.gov/18327899 DMS7UNR DI DMS7UNR DMS7UNR DN NE58043 DMS7UNR MI TTIKWV4 DMS7UNR MN Geranyltranstransferase (FDPS) DMS7UNR MT DTT DMS7UNR MA Inhibitor DMS7UNR RN Structure-activity relationships among the nitrogen containing bisphosphonates in clinical use and other analogues: time-dependent inhibition of hu... J Med Chem. 2008 Apr 10;51(7):2187-95. DMS7UNR RU https://pubmed.ncbi.nlm.nih.gov/18327899 DMHIM6N DI DMHIM6N DMHIM6N DN NE58062 DMHIM6N MI TTIKWV4 DMHIM6N MN Geranyltranstransferase (FDPS) DMHIM6N MT DTT DMHIM6N MA Inhibitor DMHIM6N RN Structure-activity relationships among the nitrogen containing bisphosphonates in clinical use and other analogues: time-dependent inhibition of hu... J Med Chem. 2008 Apr 10;51(7):2187-95. DMHIM6N RU https://pubmed.ncbi.nlm.nih.gov/18327899 DMDWESP DI DMDWESP DMDWESP DN NE97220 DMDWESP MI TTIKWV4 DMDWESP MN Geranyltranstransferase (FDPS) DMDWESP MT DTT DMDWESP MA Inhibitor DMDWESP RN Structure-activity relationships among the nitrogen containing bisphosphonates in clinical use and other analogues: time-dependent inhibition of hu... J Med Chem. 2008 Apr 10;51(7):2187-95. DMDWESP RU https://pubmed.ncbi.nlm.nih.gov/18327899 DMNCU6H DI DMNCU6H DMNCU6H DN Neamine DMNCU6H MI TT38DW5 DMNCU6H MN Bacterial 16S ribosomal RNA (Bact 16S rRNA) DMNCU6H MT DTT DMNCU6H MA Inhibitor DMNCU6H RN RNA as a target for small molecules. Curr Opin Chem Biol. 2000 Dec;4(6):678-86. DMNCU6H RU https://pubmed.ncbi.nlm.nih.gov/11102874 DMO0Q1F DI DMO0Q1F DMO0Q1F DN Nectamazin C DMO0Q1F MI TTVKILB DMO0Q1F MN Prostaglandin G/H synthase 2 (COX-2) DMO0Q1F MT DTT DMO0Q1F MA Inhibitor DMO0Q1F RN COX, LOX and platelet aggregation inhibitory properties of Lauraceae neolignans. Bioorg Med Chem Lett. 2009 Dec 15;19(24):6922-5. DMO0Q1F RU https://pubmed.ncbi.nlm.nih.gov/19880317 DM5EWIK DI DM5EWIK DM5EWIK DN NEODYSIDENIN DM5EWIK MI TT12ABZ DM5EWIK MN Arachidonate 12-lipoxygenase (12-LOX) DM5EWIK MT DTT DM5EWIK MA Inhibitor DM5EWIK RN Discovery of platelet-type 12-human lipoxygenase selective inhibitors by high-throughput screening of structurally diverse libraries. Bioorg Med Chem. 2007 Nov 15;15(22):6900-8. DM5EWIK RU https://pubmed.ncbi.nlm.nih.gov/17826100 DM6D0JC DI DM6D0JC DM6D0JC DN Neo-kauluamine DM6D0JC MI TTRSMW9 DM6D0JC MN Glycogen synthase kinase-3 beta (GSK-3B) DM6D0JC MT DTT DM6D0JC MA Inhibitor DM6D0JC RN Manzamine B and E and ircinal A related alkaloids from an Indonesian Acanthostrongylophora sponge and their activity against infectious, tropical p... J Nat Prod. 2006 Jul;69(7):1034-40. DM6D0JC RU https://pubmed.ncbi.nlm.nih.gov/16872140 DMKFPA9 DI DMKFPA9 DMKFPA9 DN NEOLIGNAN 9-NOR-7,8-DEHYDRO-ISOLICARIN B DMKFPA9 MI TTVKILB DMKFPA9 MN Prostaglandin G/H synthase 2 (COX-2) DMKFPA9 MT DTT DMKFPA9 MA Inhibitor DMKFPA9 RN COX, LOX and platelet aggregation inhibitory properties of Lauraceae neolignans. Bioorg Med Chem Lett. 2009 Dec 15;19(24):6922-5. DMKFPA9 RU https://pubmed.ncbi.nlm.nih.gov/19880317 DM5GMOJ DI DM5GMOJ DM5GMOJ DN NEORAUTENOL DM5GMOJ MI TT50QJ3 DM5GMOJ MN Influenza Neuraminidase (Influ NA) DM5GMOJ MT DTT DM5GMOJ MA Inhibitor DM5GMOJ RN Prenylated pterocarpans as bacterial neuraminidase inhibitors. Bioorg Med Chem. 2010 May 1;18(9):3335-44. DM5GMOJ RU https://pubmed.ncbi.nlm.nih.gov/20363636 DM5GMOJ DI DM5GMOJ DM5GMOJ DN NEORAUTENOL DM5GMOJ MI TTELIN2 DM5GMOJ MN PTPN1 messenger RNA (PTPN1 mRNA) DM5GMOJ MT DTT DM5GMOJ MA Inhibitor DM5GMOJ RN Cytotoxic and PTP1B inhibitory activities from Erythrina abyssinica. Bioorg Med Chem Lett. 2009 Dec 1;19(23):6745-9. DM5GMOJ RU https://pubmed.ncbi.nlm.nih.gov/19836230 DMXULGK DI DMXULGK DMXULGK DN Neplanocin A DMXULGK MI TTE2KUJ DMXULGK MN Adenosylhomocysteinase (AHCY) DMXULGK MT DTT DMXULGK MA Inhibitor DMXULGK RN Molecular approaches for the treatment of hemorrhagic fever virus infections. Antiviral Res. 1993 Sep;22(1):45-75. DMXULGK RU https://pubmed.ncbi.nlm.nih.gov/8250543 DMXULGK DI DMXULGK DMXULGK DN Neplanocin A DMXULGK MI TTQWUPT DMXULGK MN Thyroid hormone receptor (THR) DMXULGK MT DTT DMXULGK MA Antagonist DMXULGK RN Design of thyroid hormone receptor antagonists from first principles. J Steroid Biochem Mol Biol. 2002 Dec;83(1-5):59-73. DMXULGK RU https://pubmed.ncbi.nlm.nih.gov/12650702 DM3AW8X DI DM3AW8X DM3AW8X DN Nerve growth factor conjugated RAP peptide DM3AW8X MI TTEDJN4 DM3AW8X MN Low-affinity nerve growth factor receptor (NGFR) DM3AW8X MT DTT DM3AW8X MA Modulator DM3AW8X RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1888). DM3AW8X RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1888 DM1W2GZ DI DM1W2GZ DM1W2GZ DN N-ethyl estradiol-16-methyl carboxamide DM1W2GZ MI TTIWB6L DM1W2GZ MN Estradiol 17 beta-dehydrogenase 1 (17-beta-HSD1) DM1W2GZ MT DTT DM1W2GZ MA Inhibitor DM1W2GZ RN Modification of estrone at the 6, 16, and 17 positions: novel potent inhibitors of 17beta-hydroxysteroid dehydrogenase type 1. J Med Chem. 2006 Feb 23;49(4):1325-45. DM1W2GZ RU https://pubmed.ncbi.nlm.nih.gov/16480268 DMM9526 DI DMM9526 DMM9526 DN N-ethyl estrone-16-methyl carboxamide DMM9526 MI TTIWB6L DMM9526 MN Estradiol 17 beta-dehydrogenase 1 (17-beta-HSD1) DMM9526 MT DTT DMM9526 MA Inhibitor DMM9526 RN Modification of estrone at the 6, 16, and 17 positions: novel potent inhibitors of 17beta-hydroxysteroid dehydrogenase type 1. J Med Chem. 2006 Feb 23;49(4):1325-45. DMM9526 RU https://pubmed.ncbi.nlm.nih.gov/16480268 DMQ3184 DI DMQ3184 DMQ3184 DN N-ethyl-2,2,2-triphenylacetamide DMQ3184 MI TTMNI76 DMQ3184 MN Calcium-activated potassium channel (KCN) DMQ3184 MT DTT DMQ3184 MA Inhibitor DMQ3184 RN Novel inhibitors of the Gardos channel for the treatment of sickle cell disease. J Med Chem. 2008 Feb 28;51(4):976-82. DMQ3184 RU https://pubmed.ncbi.nlm.nih.gov/18232633 DMWLI4U DI DMWLI4U DMWLI4U DN N-Ethyl-2-methylnorapomorphine hydrochloride DMWLI4U MI TTEX248 DMWLI4U MN Dopamine D2 receptor (D2R) DMWLI4U MT DTT DMWLI4U MA Inhibitor DMWLI4U RN N-Substituted-2-alkyl- and 2-arylnorapomorphines: novel, highly active D2 agonists. Bioorg Med Chem. 2009 Jul 1;17(13):4756-62. DMWLI4U RU https://pubmed.ncbi.nlm.nih.gov/19454369 DM6HMBW DI DM6HMBW DM6HMBW DN N-Ethyl-2-phenylnorapomorphine hydrochloride DM6HMBW MI TTEX248 DM6HMBW MN Dopamine D2 receptor (D2R) DM6HMBW MT DTT DM6HMBW MA Inhibitor DM6HMBW RN N-Substituted-2-alkyl- and 2-arylnorapomorphines: novel, highly active D2 agonists. Bioorg Med Chem. 2009 Jul 1;17(13):4756-62. DM6HMBW RU https://pubmed.ncbi.nlm.nih.gov/19454369 DMHY35A DI DMHY35A DMHY35A DN N-ethyl-4-hydroxy-N-phenylbenzenesulfonamide DMHY35A MI TTZAYWL DMHY35A MN Estrogen receptor (ESR) DMHY35A MT DTT DMHY35A MA Inhibitor DMHY35A RN Substituted 4-hydroxyphenyl sulfonamides as pathway-selective estrogen receptor ligands. Bioorg Med Chem Lett. 2006 Feb 15;16(4):854-8. DMHY35A RU https://pubmed.ncbi.nlm.nih.gov/16300947 DM873WR DI DM873WR DM873WR DN N-ethyl-5,6-dip-tolylpyrazine-2-carboxamide DM873WR MI TT6OEDT DM873WR MN Cannabinoid receptor 1 (CB1) DM873WR MT DTT DM873WR MA Inhibitor DM873WR RN Discovery of pyrazine carboxamide CB1 antagonists: the introduction of a hydroxyl group improves the pharmaceutical properties and in vivo efficacy... Bioorg Med Chem Lett. 2007 Jul 15;17(14):3978-82. DM873WR RU https://pubmed.ncbi.nlm.nih.gov/17513109 DMPTNI8 DI DMPTNI8 DMPTNI8 DN N-Ethyl-ETAV DMPTNI8 MI TT9PB26 DMPTNI8 MN Presynaptic density protein 95 (DLG4) DMPTNI8 MT DTT DMPTNI8 MA Inhibitor DMPTNI8 RN Modified peptides as potent inhibitors of the postsynaptic density-95/N-methyl-D-aspartate receptor interaction. J Med Chem. 2008 Oct 23;51(20):6450-9. DMPTNI8 RU https://pubmed.ncbi.nlm.nih.gov/18811137 DMYI87T DI DMYI87T DMYI87T DN N-ethylhistamine DMYI87T MI TTXJ178 DMYI87T MN Histamine H4 receptor (H4R) DMYI87T MT DTT DMYI87T MA Agonist DMYI87T RN Compared pharmacology of human histamine H3 and H4 receptors: structure-activity relationships of histamine derivatives. Br J Pharmacol. 2006 Apr;147(7):744-54. DMYI87T RU https://pubmed.ncbi.nlm.nih.gov/16432504 DMMKSGL DI DMMKSGL DMMKSGL DN N-ethyl-N-methyl-4-(pyridin-3-yl)but-3-yn-1-amine DMMKSGL MI TT4H1MQ DMMKSGL MN Neuronal acetylcholine receptor alpha-4 (CHRNA4) DMMKSGL MT DTT DMMKSGL MA Inhibitor DMMKSGL RN Synthesis and analgesic activity of secondary amine analogues of pyridylmethylamine and positional isomeric analogues of ABT-594. Bioorg Med Chem Lett. 2006 Apr 1;16(7):2013-6. DMMKSGL RU https://pubmed.ncbi.nlm.nih.gov/16412637 DMMKSGL DI DMMKSGL DMMKSGL DN N-ethyl-N-methyl-4-(pyridin-3-yl)but-3-yn-1-amine DMMKSGL MI TT5KPZR DMMKSGL MN Neuronal acetylcholine receptor beta-2 (CHRNB2) DMMKSGL MT DTT DMMKSGL MA Inhibitor DMMKSGL RN Synthesis and analgesic activity of secondary amine analogues of pyridylmethylamine and positional isomeric analogues of ABT-594. Bioorg Med Chem Lett. 2006 Apr 1;16(7):2013-6. DMMKSGL RU https://pubmed.ncbi.nlm.nih.gov/16412637 DMOW2QS DI DMOW2QS DMOW2QS DN Netropsin DMOW2QS MI TTOVXHF DMOW2QS MN Human Deoxyribonucleic acid minor groove (hDNA min) DMOW2QS MT DTT DMOW2QS MA Binder (minor groove binder) DMOW2QS RN Drug-DNA binding specificity: binding of netropsin and distamycin to poly(d2NH2A-dT). Biopolymers. 1990;30(1-2):223-7. DMOW2QS RU https://pubmed.ncbi.nlm.nih.gov/2171689 DM9UXRP DI DM9UXRP DM9UXRP DN neurokinin A DM9UXRP MI TTBPGLU DM9UXRP MN Neuromedin-K receptor (TACR3) DM9UXRP MT DTT DM9UXRP MA Agonist DM9UXRP RN Molecular and pharmacological characterization of the murine tachykinin NK(3) receptor. Eur J Pharmacol. 2001 Feb 16;413(2-3):143-50. DM9UXRP RU https://pubmed.ncbi.nlm.nih.gov/11226387 DM9UXRP DI DM9UXRP DM9UXRP DN neurokinin A DM9UXRP MI TTYO0A3 DM9UXRP MN Substance-K receptor (TACR2) DM9UXRP MT DTT DM9UXRP MA Agonist DM9UXRP RN Structure-activity relationships of neurokinin A (4-10) at the human tachykinin NK(2) receptor: the role of natural residues and their chirality. Biochem Pharmacol. 2001 Jan 1;61(1):55-60. DM9UXRP RU https://pubmed.ncbi.nlm.nih.gov/11137709 DM9UXRP DI DM9UXRP DM9UXRP DN neurokinin A DM9UXRP MI TTZPO1L DM9UXRP MN Substance-P receptor (TACR1) DM9UXRP MT DTT DM9UXRP MA Agonist DM9UXRP RN Nonpeptide tachykinin receptor antagonists: I. Pharmacological and pharmacokinetic characterization of SB 223412, a novel, potent and selective neurokinin-3 receptor antagonist. J Pharmacol Exp Ther.1997 Jun;281(3):1303-11. DM9UXRP RU https://pubmed.ncbi.nlm.nih.gov/9190866 DM5O2MJ DI DM5O2MJ DM5O2MJ DN NEUROKININ B DM5O2MJ MI TTBPGLU DM5O2MJ MN Neuromedin-K receptor (TACR3) DM5O2MJ MT DTT DM5O2MJ MA Inhibitor DM5O2MJ RN The rational development of small molecule tachykinin NK3 receptor selective antagonists - the utilisation of a dipeptide chemical library in drug design, Bioorg. Med. Chem. Lett. 4(14):1679-1684 (1994). DM5O2MJ RU http://www.sciencedirect.com/science/article/pii/S0960894X00803601 DMSJ6T1 DI DMSJ6T1 DMSJ6T1 DN Neuromed 2 DMSJ6T1 MI TTXHYV6 DMSJ6T1 MN Voltage-gated L-type calcium channel (L-CaC) DMSJ6T1 MT DTT DMSJ6T1 MA Blocker DMSJ6T1 RN Recent updates of N-type calcium channel blockers with therapeutic potential for neuropathic pain and stroke. Curr Top Med Chem. 2009;9(4):377-95. DMSJ6T1 RU https://pubmed.ncbi.nlm.nih.gov/19442208 DMXKT45 DI DMXKT45 DMXKT45 DN Neuromed 5 DMXKT45 MI TTXHYV6 DMXKT45 MN Voltage-gated L-type calcium channel (L-CaC) DMXKT45 MT DTT DMXKT45 MA Blocker DMXKT45 RN Recent updates of N-type calcium channel blockers with therapeutic potential for neuropathic pain and stroke. Curr Top Med Chem. 2009;9(4):377-95. DMXKT45 RU https://pubmed.ncbi.nlm.nih.gov/19442208 DMCXJLH DI DMCXJLH DMCXJLH DN neuromedin B DMCXJLH MI TTHYDUM DMCXJLH MN Bombesin receptor (BS) DMCXJLH MT DTT DMCXJLH MA Agonist DMCXJLH RN Insights into bombesin receptors and ligands: Highlighting recent advances. Peptides. 2015 Oct;72:128-44. DMCXJLH RU https://pubmed.ncbi.nlm.nih.gov/25976083 DMCXJLH DI DMCXJLH DMCXJLH DN neuromedin B DMCXJLH MI TTC1MVT DMCXJLH MN Gastrin-releasing peptide receptor (GRPR) DMCXJLH MT DTT DMCXJLH MA Agonist DMCXJLH RN Expression and characterization of cloned human bombesin receptors. Mol Pharmacol. 1995 Jan;47(1):10-20. DMCXJLH RU https://pubmed.ncbi.nlm.nih.gov/7838118 DM27WCE DI DM27WCE DM27WCE DN NEUROTENSIN DM27WCE MI TTTUMEP DM27WCE MN Neurotensin receptor type 1 (NTSR1) DM27WCE MT DTT DM27WCE MA Inhibitor DM27WCE RN Identification of a potent, selective, and orally active leukotriene a4 hydrolase inhibitor with anti-inflammatory activity. J Med Chem. 2008 Jul 24;51(14):4150-69. DM27WCE RU https://pubmed.ncbi.nlm.nih.gov/18588282 DMOBU62 DI DMOBU62 DMOBU62 DN Neurotensin(8-13) DMOBU62 MI TTTUMEP DMOBU62 MN Neurotensin receptor type 1 (NTSR1) DMOBU62 MT DTT DMOBU62 MA Inhibitor DMOBU62 RN Comparison of N-terminal modifications on neurotensin(8-13) analogues correlates peptide stability but not binding affinity with in vivo efficacy. J Med Chem. 2009 Apr 9;52(7):1803-13. DMOBU62 RU https://pubmed.ncbi.nlm.nih.gov/19290594 DM6NS7H DI DM6NS7H DM6NS7H DN nexturastat A DM6NS7H MI TT6R7JZ DM6NS7H MN Histone deacetylase 1 (HDAC1) DM6NS7H MT DTT DM6NS7H MA Inhibitor DM6NS7H RN Selective histone deacetylase 6 inhibitors bearing substituted urea linkers inhibit melanoma cell growth. J Med Chem. 2012 Nov 26;55(22):9891-9. DM6NS7H RU https://pubmed.ncbi.nlm.nih.gov/23009203 DM6NS7H DI DM6NS7H DM6NS7H DN nexturastat A DM6NS7H MI TT5ZKDI DM6NS7H MN Histone deacetylase 6 (HDAC6) DM6NS7H MT DTT DM6NS7H MA Inhibitor DM6NS7H RN Selective histone deacetylase 6 inhibitors bearing substituted urea linkers inhibit melanoma cell growth. J Med Chem. 2012 Nov 26;55(22):9891-9. DM6NS7H RU https://pubmed.ncbi.nlm.nih.gov/23009203 DMJ4GO9 DI DMJ4GO9 DMJ4GO9 DN NF023 DMJ4GO9 MI TTJW7B3 DMJ4GO9 MN P2X purinoceptor 1 (P2RX1) DMJ4GO9 MT DTT DMJ4GO9 MA Antagonist DMJ4GO9 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 478). DMJ4GO9 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=478 DMGMH8T DI DMGMH8T DMGMH8T DN NF157 DMGMH8T MI TTYXPCO DMGMH8T MN P2Y purinoceptor 11 (P2RY11) DMGMH8T MT DTT DMGMH8T MA Antagonist DMGMH8T RN Synthesis and structure-activity relationships of suramin-derived P2Y11 receptor antagonists with nanomolar potency. J Med Chem. 2005 Nov 3;48(22):7040-8. DMGMH8T RU https://pubmed.ncbi.nlm.nih.gov/16250663 DMPSXR8 DI DMPSXR8 DMPSXR8 DN NF340 DMPSXR8 MI TTYXPCO DMPSXR8 MN P2Y purinoceptor 11 (P2RY11) DMPSXR8 MT DTT DMPSXR8 MA Antagonist DMPSXR8 RN Invited Lectures : Overviews Purinergic signalling: past, present and future. Purinergic Signal. 2006 May;2(1):1-324. DMPSXR8 RU https://pubmed.ncbi.nlm.nih.gov/18404494 DM816Z2 DI DM816Z2 DM816Z2 DN NF449 DM816Z2 MI TTJW7B3 DM816Z2 MN P2X purinoceptor 1 (P2RX1) DM816Z2 MT DTT DM816Z2 MA Antagonist DM816Z2 RN Structure-activity relationships of analogues of NF449 confirm NF449 as the most potent and selective known P2X1 receptor antagonist. Eur J Med Chem. 2004 Apr;39(4):345-57. DM816Z2 RU https://pubmed.ncbi.nlm.nih.gov/15072843 DMPZB31 DI DMPZB31 DMPZB31 DN NF546 DMPZB31 MI TTYXPCO DMPZB31 MN P2Y purinoceptor 11 (P2RY11) DMPZB31 MT DTT DMPZB31 MA Agonist DMPZB31 RN NF546 [4,4'-(carbonylbis(imino-3,1-phenylene-carbonylimino-3,1-(4-methyl-phenylene)-carbonylimino))-bis(1,3-xylene-alpha,alpha'-diphosphonic acid) tetrasodium salt] is a non-nucleotide P2Y11 agonist and stimulates release of interleukin-8 from human monocyte-derived dendritic cells. J Pharmacol Exp Ther. 2010 Jan;332(1):238-47. DMPZB31 RU https://pubmed.ncbi.nlm.nih.gov/19815812 DM7GBDX DI DM7GBDX DM7GBDX DN N-Formylmethionine DM7GBDX MI TT4QPUL DM7GBDX MN Antithrombin-III (ATIII) DM7GBDX MT DTT DM7GBDX MA Inhibitor DM7GBDX RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DM7GBDX RU https://pubmed.ncbi.nlm.nih.gov/17139284 DM7GBDX DI DM7GBDX DM7GBDX DN N-Formylmethionine DM7GBDX MI TTNFESW DM7GBDX MN Glutamate--cysteine ligase modifier (GCLM) DM7GBDX MT DTT DM7GBDX MA Inhibitor DM7GBDX RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DM7GBDX RU https://pubmed.ncbi.nlm.nih.gov/17139284 DM7GBDX DI DM7GBDX DM7GBDX DN N-Formylmethionine DM7GBDX MI TTTJF7V DM7GBDX MN NADH dehydrogenase (MT-ND3) DM7GBDX MT DTT DM7GBDX MA Inhibitor DM7GBDX RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DM7GBDX RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMC48D9 DI DMC48D9 DMC48D9 DN NG-25 DMC48D9 MI TTQFRP0 DMC48D9 MN MEK kinase kinase 2 (MAP4K2) DMC48D9 MT DTT DMC48D9 MA Inhibitor DMC48D9 RN Discovery of type II inhibitors of TGFbeta-activated kinase 1 (TAK1) and mitogen-activated protein kinase kinase kinase kinase 2 (MAP4K2). J Med Chem. 2015 Jan 8;58(1):183-96. DMC48D9 RU https://pubmed.ncbi.nlm.nih.gov/25075558 DMC48D9 DI DMC48D9 DMC48D9 DN NG-25 DMC48D9 MI TT6PKBN DMC48D9 MN Proto-oncogene c-Src (SRC) DMC48D9 MT DTT DMC48D9 MA Inhibitor DMC48D9 RN Discovery of type II inhibitors of TGFbeta-activated kinase 1 (TAK1) and mitogen-activated protein kinase kinase kinase kinase 2 (MAP4K2). J Med Chem. 2015 Jan 8;58(1):183-96. DMC48D9 RU https://pubmed.ncbi.nlm.nih.gov/25075558 DMC48D9 DI DMC48D9 DMC48D9 DN NG-25 DMC48D9 MI TTJQT60 DMC48D9 MN TGF-beta-activated kinase 1 (MAP3K7) DMC48D9 MT DTT DMC48D9 MA Inhibitor DMC48D9 RN Discovery of type II inhibitors of TGFbeta-activated kinase 1 (TAK1) and mitogen-activated protein kinase kinase kinase kinase 2 (MAP4K2). J Med Chem. 2015 Jan 8;58(1):183-96. DMC48D9 RU https://pubmed.ncbi.nlm.nih.gov/25075558 DMC48D9 DI DMC48D9 DMC48D9 DN NG-25 DMC48D9 MI TTX6F0Q DMC48D9 MN Tyrosine-protein kinase CSK (CSK) DMC48D9 MT DTT DMC48D9 MA Inhibitor DMC48D9 RN Discovery of type II inhibitors of TGFbeta-activated kinase 1 (TAK1) and mitogen-activated protein kinase kinase kinase kinase 2 (MAP4K2). J Med Chem. 2015 Jan 8;58(1):183-96. DMC48D9 RU https://pubmed.ncbi.nlm.nih.gov/25075558 DMC48D9 DI DMC48D9 DMC48D9 DN NG-25 DMC48D9 MI TT1RWNJ DMC48D9 MN Tyrosine-protein kinase Lyn (JTK8) DMC48D9 MT DTT DMC48D9 MA Inhibitor DMC48D9 RN Discovery of type II inhibitors of TGFbeta-activated kinase 1 (TAK1) and mitogen-activated protein kinase kinase kinase kinase 2 (MAP4K2). J Med Chem. 2015 Jan 8;58(1):183-96. DMC48D9 RU https://pubmed.ncbi.nlm.nih.gov/25075558 DMMC42Z DI DMMC42Z DMMC42Z DN NGB 2904 DMMC42Z MI TT4C8EA DMMC42Z MN Dopamine D3 receptor (D3R) DMMC42Z MT DTT DMMC42Z MA Antagonist DMMC42Z RN Pharmacological actions of NGB 2904, a selective dopamine D3 receptor antagonist, in animal models of drug addiction. CNS Drug Rev. 2007 Summer;13(2):240-59. DMMC42Z RU https://pubmed.ncbi.nlm.nih.gov/17627675 DMWD7I3 DI DMWD7I3 DMWD7I3 DN NGD 96-3 DMWD7I3 MI TTEX6LM DMWD7I3 MN GABA(A) receptor gamma-3 (GABRG3) DMWD7I3 MT DTT DMWD7I3 MA Modulator DMWD7I3 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 415). DMWD7I3 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=415 DMPEZHC DI DMPEZHC DMPEZHC DN N-glycylglycinehydroxamic acid DMPEZHC MI TTAS2UO DMPEZHC MN Bacterial Urease (Bact ureC) DMPEZHC MT DTT DMPEZHC MA Inhibitor DMPEZHC RN Design, synthesis, and evaluation of novel organophosphorus inhibitors of bacterial ureases. J Med Chem. 2008 Sep 25;51(18):5736-44. DMPEZHC RU https://pubmed.ncbi.nlm.nih.gov/18717581 DMBG3ZF DI DMBG3ZF DMBG3ZF DN N-guanyl-1,7-diaminoheptane DMBG3ZF MI TTBO2A9 DMBG3ZF MN Deoxyhypusine synthase (DHPS) DMBG3ZF MT DTT DMBG3ZF MA Inhibitor DMBG3ZF RN Modification of eukaryotic initiation factor 5A from Plasmodium vivax by a truncated deoxyhypusine synthase from Plasmodium falciparum: An enzyme w... Bioorg Med Chem. 2007 Sep 15;15(18):6200-7. DMBG3ZF RU https://pubmed.ncbi.nlm.nih.gov/17591443 DMYAB79 DI DMYAB79 DMYAB79 DN NH-3 DMYAB79 MI TTQWUPT DMYAB79 MN Thyroid hormone receptor (THR) DMYAB79 MT DTT DMYAB79 MA Antagonist DMYAB79 RN Design of thyroid hormone receptor antagonists from first principles. J Steroid Biochem Mol Biol. 2002 Dec;83(1-5):59-73. DMYAB79 RU https://pubmed.ncbi.nlm.nih.gov/12650702 DMSUZFO DI DMSUZFO DMSUZFO DN NH-4 DMSUZFO MI TTQWUPT DMSUZFO MN Thyroid hormone receptor (THR) DMSUZFO MT DTT DMSUZFO MA Antagonist DMSUZFO RN Design of thyroid hormone receptor antagonists from first principles. J Steroid Biochem Mol Biol. 2002 Dec;83(1-5):59-73. DMSUZFO RU https://pubmed.ncbi.nlm.nih.gov/12650702 DMM0F2G DI DMM0F2G DMM0F2G DN N-Hexyl-2-(2-phenyl-1H-indol-3-yl)-acetamide DMM0F2G MI TTPTXIN DMM0F2G MN Translocator protein (TSPO) DMM0F2G MT DTT DMM0F2G MA Inhibitor DMM0F2G RN Chemistry, binding affinities, and behavioral properties of a new class of "antineophobic" mitochondrial DBI receptor complex (mDRC) ligands. J Med Chem. 1993 Oct 1;36(20):2908-20. DMM0F2G RU https://pubmed.ncbi.nlm.nih.gov/8411007 DML27CG DI DML27CG DML27CG DN N-Hexylcarbamic Acid Biphenyl-3-yl Ester DML27CG MI TTDP1UC DML27CG MN Fatty acid amide hydrolase (FAAH) DML27CG MT DTT DML27CG MA Inhibitor DML27CG RN Synthesis and quantitative structure-activity relationship of fatty acid amide hydrolase inhibitors: modulation at the N-portion of biphenyl-3-yl a... J Med Chem. 2008 Jun 26;51(12):3487-98. DML27CG RU https://pubmed.ncbi.nlm.nih.gov/18507372 DMZ2T59 DI DMZ2T59 DMZ2T59 DN N-hydroxy-1-naphthamide DMZ2T59 MI TTT6LFV DMZ2T59 MN Histone deacetylase 8 (HDAC8) DMZ2T59 MT DTT DMZ2T59 MA Inhibitor DMZ2T59 RN Design and evaluation of 'Linkerless' hydroxamic acids as selective HDAC8 inhibitors. Bioorg Med Chem Lett. 2007 May 15;17(10):2874-8. DMZ2T59 RU https://pubmed.ncbi.nlm.nih.gov/17346959 DM56P1I DI DM56P1I DM56P1I DN N-Hydroxy-2-(4-methoxy-benzenesulfonyl)benzamide DM56P1I MI TTXZ0KQ DM56P1I MN Matrix metalloproteinase-12 (MMP-12) DM56P1I MT DTT DM56P1I MA Inhibitor DM56P1I RN Design, synthesis, biological evaluation, and NMR studies of a new series of arylsulfones as selective and potent matrix metalloproteinase-12 inhib... J Med Chem. 2009 Oct 22;52(20):6347-61. DM56P1I RU https://pubmed.ncbi.nlm.nih.gov/19775099 DM50NKS DI DM50NKS DM50NKS DN N-hydroxy-2-(4-methoxyphenylsulfonamido)acetamide DM50NKS MI TTJ4QE7 DM50NKS MN Matrix metalloproteinase-14 (MMP-14) DM50NKS MT DTT DM50NKS MA Inhibitor DM50NKS RN Potent arylsulfonamide inhibitors of tumor necrosis factor-alpha converting enzyme able to reduce activated leukocyte cell adhesion molecule sheddi... J Med Chem. 2010 Mar 25;53(6):2622-35. DM50NKS RU https://pubmed.ncbi.nlm.nih.gov/20180536 DM50NKS DI DM50NKS DM50NKS DN N-hydroxy-2-(4-methoxyphenylsulfonamido)acetamide DM50NKS MI TT6AZXG DM50NKS MN TNF alpha converting enzyme (ADAM17) DM50NKS MT DTT DM50NKS MA Inhibitor DM50NKS RN Potent arylsulfonamide inhibitors of tumor necrosis factor-alpha converting enzyme able to reduce activated leukocyte cell adhesion molecule sheddi... J Med Chem. 2010 Mar 25;53(6):2622-35. DM50NKS RU https://pubmed.ncbi.nlm.nih.gov/20180536 DM4VADN DI DM4VADN DM4VADN DN N-Hydroxy-2-(4-phenoxy-benzenesulfonyl)benzamide DM4VADN MI TTXZ0KQ DM4VADN MN Matrix metalloproteinase-12 (MMP-12) DM4VADN MT DTT DM4VADN MA Inhibitor DM4VADN RN Design, synthesis, biological evaluation, and NMR studies of a new series of arylsulfones as selective and potent matrix metalloproteinase-12 inhib... J Med Chem. 2009 Oct 22;52(20):6347-61. DM4VADN RU https://pubmed.ncbi.nlm.nih.gov/19775099 DM4VADN DI DM4VADN DM4VADN DN N-Hydroxy-2-(4-phenoxy-benzenesulfonyl)benzamide DM4VADN MI TTHY57M DM4VADN MN Matrix metalloproteinase-13 (MMP-13) DM4VADN MT DTT DM4VADN MA Inhibitor DM4VADN RN Design, synthesis, biological evaluation, and NMR studies of a new series of arylsulfones as selective and potent matrix metalloproteinase-12 inhib... J Med Chem. 2009 Oct 22;52(20):6347-61. DM4VADN RU https://pubmed.ncbi.nlm.nih.gov/19775099 DM4VADN DI DM4VADN DM4VADN DN N-Hydroxy-2-(4-phenoxy-benzenesulfonyl)benzamide DM4VADN MI TTJ4QE7 DM4VADN MN Matrix metalloproteinase-14 (MMP-14) DM4VADN MT DTT DM4VADN MA Inhibitor DM4VADN RN Design, synthesis, biological evaluation, and NMR studies of a new series of arylsulfones as selective and potent matrix metalloproteinase-12 inhib... J Med Chem. 2009 Oct 22;52(20):6347-61. DM4VADN RU https://pubmed.ncbi.nlm.nih.gov/19775099 DM4VADN DI DM4VADN DM4VADN DN N-Hydroxy-2-(4-phenoxy-benzenesulfonyl)benzamide DM4VADN MI TTLM12X DM4VADN MN Matrix metalloproteinase-2 (MMP-2) DM4VADN MT DTT DM4VADN MA Inhibitor DM4VADN RN Design, synthesis, biological evaluation, and NMR studies of a new series of arylsulfones as selective and potent matrix metalloproteinase-12 inhib... J Med Chem. 2009 Oct 22;52(20):6347-61. DM4VADN RU https://pubmed.ncbi.nlm.nih.gov/19775099 DM4VADN DI DM4VADN DM4VADN DN N-Hydroxy-2-(4-phenoxy-benzenesulfonyl)benzamide DM4VADN MI TTYRF5E DM4VADN MN Matrix metalloproteinase-21 (MMP-21) DM4VADN MT DTT DM4VADN MA Inhibitor DM4VADN RN Design, synthesis, biological evaluation, and NMR studies of a new series of arylsulfones as selective and potent matrix metalloproteinase-12 inhib... J Med Chem. 2009 Oct 22;52(20):6347-61. DM4VADN RU https://pubmed.ncbi.nlm.nih.gov/19775099 DM4VADN DI DM4VADN DM4VADN DN N-Hydroxy-2-(4-phenoxy-benzenesulfonyl)benzamide DM4VADN MI TTGA1IV DM4VADN MN Matrix metalloproteinase-8 (MMP-8) DM4VADN MT DTT DM4VADN MA Inhibitor DM4VADN RN Design, synthesis, biological evaluation, and NMR studies of a new series of arylsulfones as selective and potent matrix metalloproteinase-12 inhib... J Med Chem. 2009 Oct 22;52(20):6347-61. DM4VADN RU https://pubmed.ncbi.nlm.nih.gov/19775099 DM4VADN DI DM4VADN DM4VADN DN N-Hydroxy-2-(4-phenoxy-benzenesulfonyl)benzamide DM4VADN MI TT6X50U DM4VADN MN Matrix metalloproteinase-9 (MMP-9) DM4VADN MT DTT DM4VADN MA Inhibitor DM4VADN RN Design, synthesis, biological evaluation, and NMR studies of a new series of arylsulfones as selective and potent matrix metalloproteinase-12 inhib... J Med Chem. 2009 Oct 22;52(20):6347-61. DM4VADN RU https://pubmed.ncbi.nlm.nih.gov/19775099 DMISXUM DI DMISXUM DMISXUM DN N-Hydroxy-2-(naphthalen-2-ylsulfanyl)-acetamide DMISXUM MI TTPHMWB DMISXUM MN Aminopeptidase N (ANPEP) DMISXUM MT DTT DMISXUM MA Inhibitor DMISXUM RN N-hydroxy-2-(naphthalene-2-ylsulfanyl)-acetamide, a novel hydroxamic acid-based inhibitor of aminopeptidase N and its anti-angiogenic activity. Bioorg Med Chem Lett. 2005 Jan 3;15(1):181-3. DMISXUM RU https://pubmed.ncbi.nlm.nih.gov/15582436 DMWIMR4 DI DMWIMR4 DMWIMR4 DN N-hydroxy-2,2'-bithiophene-5-carboxamide DMWIMR4 MI TT6R7JZ DMWIMR4 MN Histone deacetylase 1 (HDAC1) DMWIMR4 MT DTT DMWIMR4 MA Inhibitor DMWIMR4 RN Identification and optimisation of a series of substituted 5-pyridin-2-yl-thiophene-2-hydroxamic acids as potent histone deacetylase (HDAC) inhibit... Bioorg Med Chem Lett. 2007 Jan 15;17(2):363-9. DMWIMR4 RU https://pubmed.ncbi.nlm.nih.gov/17107790 DMX3KRQ DI DMX3KRQ DMX3KRQ DN N-hydroxy-2,2-diphenylacetamide DMX3KRQ MI TTBH0VX DMX3KRQ MN Histone deacetylase (HDAC) DMX3KRQ MT DTT DMX3KRQ MA Inhibitor DMX3KRQ RN Diphenylmethylene hydroxamic acids as selective class IIa histone deacetylase inhibitors. Bioorg Med Chem Lett. 2009 Oct 1;19(19):5684-8. DMX3KRQ RU https://pubmed.ncbi.nlm.nih.gov/19699639 DMX3KRQ DI DMX3KRQ DMX3KRQ DN N-hydroxy-2,2-diphenylacetamide DMX3KRQ MI TTTQGH8 DMX3KRQ MN Histone deacetylase 4 (HDAC4) DMX3KRQ MT DTT DMX3KRQ MA Inhibitor DMX3KRQ RN Diphenylmethylene hydroxamic acids as selective class IIa histone deacetylase inhibitors. Bioorg Med Chem Lett. 2009 Oct 1;19(19):5684-8. DMX3KRQ RU https://pubmed.ncbi.nlm.nih.gov/19699639 DM7I2TD DI DM7I2TD DM7I2TD DN N-hydroxy-2,2-diphenylpropanamide DM7I2TD MI TTBH0VX DM7I2TD MN Histone deacetylase (HDAC) DM7I2TD MT DTT DM7I2TD MA Inhibitor DM7I2TD RN Diphenylmethylene hydroxamic acids as selective class IIa histone deacetylase inhibitors. Bioorg Med Chem Lett. 2009 Oct 1;19(19):5684-8. DM7I2TD RU https://pubmed.ncbi.nlm.nih.gov/19699639 DM7I2TD DI DM7I2TD DM7I2TD DN N-hydroxy-2,2-diphenylpropanamide DM7I2TD MI TTTQGH8 DM7I2TD MN Histone deacetylase 4 (HDAC4) DM7I2TD MT DTT DM7I2TD MA Inhibitor DM7I2TD RN Diphenylmethylene hydroxamic acids as selective class IIa histone deacetylase inhibitors. Bioorg Med Chem Lett. 2009 Oct 1;19(19):5684-8. DM7I2TD RU https://pubmed.ncbi.nlm.nih.gov/19699639 DMZWIVJ DI DMZWIVJ DMZWIVJ DN N-hydroxy-2,3-bis(phenylsulfonamido)propanamide DMZWIVJ MI TTYRF5E DMZWIVJ MN Matrix metalloproteinase-21 (MMP-21) DMZWIVJ MT DTT DMZWIVJ MA Inhibitor DMZWIVJ RN Novel bis-(arylsulfonamide) hydroxamate-based selective MMP inhibitors. Bioorg Med Chem Lett. 2008 Jun 1;18(11):3333-7. DMZWIVJ RU https://pubmed.ncbi.nlm.nih.gov/18442906 DMZWIVJ DI DMZWIVJ DMZWIVJ DN N-hydroxy-2,3-bis(phenylsulfonamido)propanamide DMZWIVJ MI TTMTWOS DMZWIVJ MN Matrix metalloproteinase-7 (MMP-7) DMZWIVJ MT DTT DMZWIVJ MA Inhibitor DMZWIVJ RN Novel bis-(arylsulfonamide) hydroxamate-based selective MMP inhibitors. Bioorg Med Chem Lett. 2008 Jun 1;18(11):3333-7. DMZWIVJ RU https://pubmed.ncbi.nlm.nih.gov/18442906 DMZWIVJ DI DMZWIVJ DMZWIVJ DN N-hydroxy-2,3-bis(phenylsulfonamido)propanamide DMZWIVJ MI TT6X50U DMZWIVJ MN Matrix metalloproteinase-9 (MMP-9) DMZWIVJ MT DTT DMZWIVJ MA Inhibitor DMZWIVJ RN Novel bis-(arylsulfonamide) hydroxamate-based selective MMP inhibitors. Bioorg Med Chem Lett. 2008 Jun 1;18(11):3333-7. DMZWIVJ RU https://pubmed.ncbi.nlm.nih.gov/18442906 DME96RF DI DME96RF DME96RF DN N-Hydroxy-2-methyl-3-naphthalen-2-yl-acrylamide DME96RF MI TT2J34L DME96RF MN Arachidonate 5-lipoxygenase (5-LOX) DME96RF MT DTT DME96RF MA Inhibitor DME96RF RN Hydroxamic acid inhibitors of 5-lipoxygenase: quantitative structure-activity relationships. J Med Chem. 1990 Mar;33(3):992-8. DME96RF RU https://pubmed.ncbi.nlm.nih.gov/2308149 DMYDX34 DI DMYDX34 DMYDX34 DN N-Hydroxy-2-naphthalen-2-yl-acetamide DMYDX34 MI TT2J34L DMYDX34 MN Arachidonate 5-lipoxygenase (5-LOX) DMYDX34 MT DTT DMYDX34 MA Inhibitor DMYDX34 RN Hydroxamic acid inhibitors of 5-lipoxygenase: quantitative structure-activity relationships. J Med Chem. 1990 Mar;33(3):992-8. DMYDX34 RU https://pubmed.ncbi.nlm.nih.gov/2308149 DMWXUCT DI DMWXUCT DMWXUCT DN N-hydroxy-3-(2-oxo-2H-chromen-3-yl)propanamide DMWXUCT MI TTLM12X DMWXUCT MN Matrix metalloproteinase-2 (MMP-2) DMWXUCT MT DTT DMWXUCT MA Inhibitor DMWXUCT RN Chromen-based TNF-alpha converting enzyme (TACE) inhibitors: design, synthesis, and biological evaluation. Bioorg Med Chem. 2008 Jan 1;16(1):530-5. DMWXUCT RU https://pubmed.ncbi.nlm.nih.gov/17936631 DMWXUCT DI DMWXUCT DMWXUCT DN N-hydroxy-3-(2-oxo-2H-chromen-3-yl)propanamide DMWXUCT MI TT6X50U DMWXUCT MN Matrix metalloproteinase-9 (MMP-9) DMWXUCT MT DTT DMWXUCT MA Inhibitor DMWXUCT RN Chromen-based TNF-alpha converting enzyme (TACE) inhibitors: design, synthesis, and biological evaluation. Bioorg Med Chem. 2008 Jan 1;16(1):530-5. DMWXUCT RU https://pubmed.ncbi.nlm.nih.gov/17936631 DMWXUCT DI DMWXUCT DMWXUCT DN N-hydroxy-3-(2-oxo-2H-chromen-3-yl)propanamide DMWXUCT MI TT6AZXG DMWXUCT MN TNF alpha converting enzyme (ADAM17) DMWXUCT MT DTT DMWXUCT MA Inhibitor DMWXUCT RN Chromen-based TNF-alpha converting enzyme (TACE) inhibitors: design, synthesis, and biological evaluation. Bioorg Med Chem. 2008 Jan 1;16(1):530-5. DMWXUCT RU https://pubmed.ncbi.nlm.nih.gov/17936631 DMA6EPH DI DMA6EPH DMA6EPH DN N-hydroxy-3-(6-methoxy-2-oxo-2H-chromen-3-yl) DMA6EPH MI TTLM12X DMA6EPH MN Matrix metalloproteinase-2 (MMP-2) DMA6EPH MT DTT DMA6EPH MA Inhibitor DMA6EPH RN Chromen-based TNF-alpha converting enzyme (TACE) inhibitors: design, synthesis, and biological evaluation. Bioorg Med Chem. 2008 Jan 1;16(1):530-5. DMA6EPH RU https://pubmed.ncbi.nlm.nih.gov/17936631 DMA6EPH DI DMA6EPH DMA6EPH DN N-hydroxy-3-(6-methoxy-2-oxo-2H-chromen-3-yl) DMA6EPH MI TT6X50U DMA6EPH MN Matrix metalloproteinase-9 (MMP-9) DMA6EPH MT DTT DMA6EPH MA Inhibitor DMA6EPH RN Chromen-based TNF-alpha converting enzyme (TACE) inhibitors: design, synthesis, and biological evaluation. Bioorg Med Chem. 2008 Jan 1;16(1):530-5. DMA6EPH RU https://pubmed.ncbi.nlm.nih.gov/17936631 DMA6EPH DI DMA6EPH DMA6EPH DN N-hydroxy-3-(6-methoxy-2-oxo-2H-chromen-3-yl) DMA6EPH MI TT6AZXG DMA6EPH MN TNF alpha converting enzyme (ADAM17) DMA6EPH MT DTT DMA6EPH MA Inhibitor DMA6EPH RN Chromen-based TNF-alpha converting enzyme (TACE) inhibitors: design, synthesis, and biological evaluation. Bioorg Med Chem. 2008 Jan 1;16(1):530-5. DMA6EPH RU https://pubmed.ncbi.nlm.nih.gov/17936631 DMY6Z0U DI DMY6Z0U DMY6Z0U DN N-hydroxy-3-(naphthalen-1-yl)acrylamide DMY6Z0U MI TTT6LFV DMY6Z0U MN Histone deacetylase 8 (HDAC8) DMY6Z0U MT DTT DMY6Z0U MA Inhibitor DMY6Z0U RN Design and evaluation of 'Linkerless' hydroxamic acids as selective HDAC8 inhibitors. Bioorg Med Chem Lett. 2007 May 15;17(10):2874-8. DMY6Z0U RU https://pubmed.ncbi.nlm.nih.gov/17346959 DMZ3INJ DI DMZ3INJ DMZ3INJ DN N-Hydroxy-3-naphthalen-2-yl-acrylamide DMZ3INJ MI TT2J34L DMZ3INJ MN Arachidonate 5-lipoxygenase (5-LOX) DMZ3INJ MT DTT DMZ3INJ MA Inhibitor DMZ3INJ RN Hydroxamic acid inhibitors of 5-lipoxygenase: quantitative structure-activity relationships. J Med Chem. 1990 Mar;33(3):992-8. DMZ3INJ RU https://pubmed.ncbi.nlm.nih.gov/2308149 DMVOPXE DI DMVOPXE DMVOPXE DN N-Hydroxy-3-naphthalen-2-yl-N-phenyl-acrylamide DMVOPXE MI TT2J34L DMVOPXE MN Arachidonate 5-lipoxygenase (5-LOX) DMVOPXE MT DTT DMVOPXE MA Inhibitor DMVOPXE RN Hydroxamic acid inhibitors of 5-lipoxygenase: quantitative structure-activity relationships. J Med Chem. 1990 Mar;33(3):992-8. DMVOPXE RU https://pubmed.ncbi.nlm.nih.gov/2308149 DMKBACJ DI DMKBACJ DMKBACJ DN N-Hydroxy-3-naphthalen-2-yl-N-p-tolyl-acrylamide DMKBACJ MI TT2J34L DMKBACJ MN Arachidonate 5-lipoxygenase (5-LOX) DMKBACJ MT DTT DMKBACJ MA Inhibitor DMKBACJ RN Hydroxamic acid inhibitors of 5-lipoxygenase: quantitative structure-activity relationships. J Med Chem. 1990 Mar;33(3):992-8. DMKBACJ RU https://pubmed.ncbi.nlm.nih.gov/2308149 DMPIMRC DI DMPIMRC DMPIMRC DN N-Hydroxy-3-naphthalen-2-yl-propionamide DMPIMRC MI TT2J34L DMPIMRC MN Arachidonate 5-lipoxygenase (5-LOX) DMPIMRC MT DTT DMPIMRC MA Inhibitor DMPIMRC RN Hydroxamic acid inhibitors of 5-lipoxygenase: quantitative structure-activity relationships. J Med Chem. 1990 Mar;33(3):992-8. DMPIMRC RU https://pubmed.ncbi.nlm.nih.gov/2308149 DMTZ8RQ DI DMTZ8RQ DMTZ8RQ DN N-hydroxy-3-phenoxybenzamide DMTZ8RQ MI TTT6LFV DMTZ8RQ MN Histone deacetylase 8 (HDAC8) DMTZ8RQ MT DTT DMTZ8RQ MA Inhibitor DMTZ8RQ RN Design and evaluation of 'Linkerless' hydroxamic acids as selective HDAC8 inhibitors. Bioorg Med Chem Lett. 2007 May 15;17(10):2874-8. DMTZ8RQ RU https://pubmed.ncbi.nlm.nih.gov/17346959 DM9IPTV DI DM9IPTV DM9IPTV DN N-Hydroxy-3-phenyl-acrylamide DM9IPTV MI TT2J34L DM9IPTV MN Arachidonate 5-lipoxygenase (5-LOX) DM9IPTV MT DTT DM9IPTV MA Inhibitor DM9IPTV RN Hydroxamic acid inhibitors of 5-lipoxygenase: quantitative structure-activity relationships. J Med Chem. 1990 Mar;33(3):992-8. DM9IPTV RU https://pubmed.ncbi.nlm.nih.gov/2308149 DMCN91A DI DMCN91A DMCN91A DN N-Hydroxy-4-((R)-2-phenyl-butyrylamino)-benzamide DMCN91A MI TTBH0VX DMCN91A MN Histone deacetylase (HDAC) DMCN91A MT DTT DMCN91A MA Inhibitor DMCN91A RN Structure-based optimization of phenylbutyrate-derived histone deacetylase inhibitors. J Med Chem. 2005 Aug 25;48(17):5530-5. DMCN91A RU https://pubmed.ncbi.nlm.nih.gov/16107152 DMCN91A DI DMCN91A DMCN91A DN N-Hydroxy-4-((R)-2-phenyl-butyrylamino)-benzamide DMCN91A MI TT6R7JZ DMCN91A MN Histone deacetylase 1 (HDAC1) DMCN91A MT DTT DMCN91A MA Inhibitor DMCN91A RN Structure-based optimization of phenylbutyrate-derived histone deacetylase inhibitors. J Med Chem. 2005 Aug 25;48(17):5530-5. DMCN91A RU https://pubmed.ncbi.nlm.nih.gov/16107152 DMCN91A DI DMCN91A DMCN91A DN N-Hydroxy-4-((R)-2-phenyl-butyrylamino)-benzamide DMCN91A MI TTYHPU6 DMCN91A MN Histone deacetylase 10 (HDAC10) DMCN91A MT DTT DMCN91A MA Inhibitor DMCN91A RN Structure-based optimization of phenylbutyrate-derived histone deacetylase inhibitors. J Med Chem. 2005 Aug 25;48(17):5530-5. DMCN91A RU https://pubmed.ncbi.nlm.nih.gov/16107152 DMCN91A DI DMCN91A DMCN91A DN N-Hydroxy-4-((R)-2-phenyl-butyrylamino)-benzamide DMCN91A MI TTSHTOI DMCN91A MN Histone deacetylase 2 (HDAC2) DMCN91A MT DTT DMCN91A MA Inhibitor DMCN91A RN Structure-based optimization of phenylbutyrate-derived histone deacetylase inhibitors. J Med Chem. 2005 Aug 25;48(17):5530-5. DMCN91A RU https://pubmed.ncbi.nlm.nih.gov/16107152 DMCN91A DI DMCN91A DMCN91A DN N-Hydroxy-4-((R)-2-phenyl-butyrylamino)-benzamide DMCN91A MI TTTQGH8 DMCN91A MN Histone deacetylase 4 (HDAC4) DMCN91A MT DTT DMCN91A MA Inhibitor DMCN91A RN Structure-based optimization of phenylbutyrate-derived histone deacetylase inhibitors. J Med Chem. 2005 Aug 25;48(17):5530-5. DMCN91A RU https://pubmed.ncbi.nlm.nih.gov/16107152 DMCN91A DI DMCN91A DMCN91A DN N-Hydroxy-4-((R)-2-phenyl-butyrylamino)-benzamide DMCN91A MI TT5ZKDI DMCN91A MN Histone deacetylase 6 (HDAC6) DMCN91A MT DTT DMCN91A MA Inhibitor DMCN91A RN Structure-based optimization of phenylbutyrate-derived histone deacetylase inhibitors. J Med Chem. 2005 Aug 25;48(17):5530-5. DMCN91A RU https://pubmed.ncbi.nlm.nih.gov/16107152 DMCN91A DI DMCN91A DMCN91A DN N-Hydroxy-4-((R)-2-phenyl-butyrylamino)-benzamide DMCN91A MI TTT6LFV DMCN91A MN Histone deacetylase 8 (HDAC8) DMCN91A MT DTT DMCN91A MA Inhibitor DMCN91A RN Structure-based optimization of phenylbutyrate-derived histone deacetylase inhibitors. J Med Chem. 2005 Aug 25;48(17):5530-5. DMCN91A RU https://pubmed.ncbi.nlm.nih.gov/16107152 DMVK2Y3 DI DMVK2Y3 DMVK2Y3 DN N-Hydroxy-4-((S)-2-phenyl-butyrylamino)-benzamide DMVK2Y3 MI TTBH0VX DMVK2Y3 MN Histone deacetylase (HDAC) DMVK2Y3 MT DTT DMVK2Y3 MA Inhibitor DMVK2Y3 RN Structure-based optimization of phenylbutyrate-derived histone deacetylase inhibitors. J Med Chem. 2005 Aug 25;48(17):5530-5. DMVK2Y3 RU https://pubmed.ncbi.nlm.nih.gov/16107152 DMVK2Y3 DI DMVK2Y3 DMVK2Y3 DN N-Hydroxy-4-((S)-2-phenyl-butyrylamino)-benzamide DMVK2Y3 MI TT6R7JZ DMVK2Y3 MN Histone deacetylase 1 (HDAC1) DMVK2Y3 MT DTT DMVK2Y3 MA Inhibitor DMVK2Y3 RN Structure-based optimization of phenylbutyrate-derived histone deacetylase inhibitors. J Med Chem. 2005 Aug 25;48(17):5530-5. DMVK2Y3 RU https://pubmed.ncbi.nlm.nih.gov/16107152 DMVK2Y3 DI DMVK2Y3 DMVK2Y3 DN N-Hydroxy-4-((S)-2-phenyl-butyrylamino)-benzamide DMVK2Y3 MI TTYHPU6 DMVK2Y3 MN Histone deacetylase 10 (HDAC10) DMVK2Y3 MT DTT DMVK2Y3 MA Inhibitor DMVK2Y3 RN Structure-based optimization of phenylbutyrate-derived histone deacetylase inhibitors. J Med Chem. 2005 Aug 25;48(17):5530-5. DMVK2Y3 RU https://pubmed.ncbi.nlm.nih.gov/16107152 DMVK2Y3 DI DMVK2Y3 DMVK2Y3 DN N-Hydroxy-4-((S)-2-phenyl-butyrylamino)-benzamide DMVK2Y3 MI TTSHTOI DMVK2Y3 MN Histone deacetylase 2 (HDAC2) DMVK2Y3 MT DTT DMVK2Y3 MA Inhibitor DMVK2Y3 RN Structure-based optimization of phenylbutyrate-derived histone deacetylase inhibitors. J Med Chem. 2005 Aug 25;48(17):5530-5. DMVK2Y3 RU https://pubmed.ncbi.nlm.nih.gov/16107152 DMVK2Y3 DI DMVK2Y3 DMVK2Y3 DN N-Hydroxy-4-((S)-2-phenyl-butyrylamino)-benzamide DMVK2Y3 MI TTTQGH8 DMVK2Y3 MN Histone deacetylase 4 (HDAC4) DMVK2Y3 MT DTT DMVK2Y3 MA Inhibitor DMVK2Y3 RN Structure-based optimization of phenylbutyrate-derived histone deacetylase inhibitors. J Med Chem. 2005 Aug 25;48(17):5530-5. DMVK2Y3 RU https://pubmed.ncbi.nlm.nih.gov/16107152 DMVK2Y3 DI DMVK2Y3 DMVK2Y3 DN N-Hydroxy-4-((S)-2-phenyl-butyrylamino)-benzamide DMVK2Y3 MI TT5ZKDI DMVK2Y3 MN Histone deacetylase 6 (HDAC6) DMVK2Y3 MT DTT DMVK2Y3 MA Inhibitor DMVK2Y3 RN Structure-based optimization of phenylbutyrate-derived histone deacetylase inhibitors. J Med Chem. 2005 Aug 25;48(17):5530-5. DMVK2Y3 RU https://pubmed.ncbi.nlm.nih.gov/16107152 DMVK2Y3 DI DMVK2Y3 DMVK2Y3 DN N-Hydroxy-4-((S)-2-phenyl-butyrylamino)-benzamide DMVK2Y3 MI TTT6LFV DMVK2Y3 MN Histone deacetylase 8 (HDAC8) DMVK2Y3 MT DTT DMVK2Y3 MA Inhibitor DMVK2Y3 RN Structure-based optimization of phenylbutyrate-derived histone deacetylase inhibitors. J Med Chem. 2005 Aug 25;48(17):5530-5. DMVK2Y3 RU https://pubmed.ncbi.nlm.nih.gov/16107152 DMKELRB DI DMKELRB DMKELRB DN N-hydroxy-4-(2-oleamidoethyl)benzamide DMKELRB MI TTIQSC1 DMKELRB MN Bacterial Lethal factor (Bact lef) DMKELRB MT DTT DMKELRB MA Inhibitor DMKELRB RN Inhibitors of anthrax lethal factor. Bioorg Med Chem Lett. 2007 Aug 15;17(16):4575-8. DMKELRB RU https://pubmed.ncbi.nlm.nih.gov/17574849 DMHEQ41 DI DMHEQ41 DMHEQ41 DN N-Hydroxy-4-(2-phenyl-butyrylamino)-benzamide DMHEQ41 MI TTBH0VX DMHEQ41 MN Histone deacetylase (HDAC) DMHEQ41 MT DTT DMHEQ41 MA Inhibitor DMHEQ41 RN Structure-based optimization of phenylbutyrate-derived histone deacetylase inhibitors. J Med Chem. 2005 Aug 25;48(17):5530-5. DMHEQ41 RU https://pubmed.ncbi.nlm.nih.gov/16107152 DMHEQ41 DI DMHEQ41 DMHEQ41 DN N-Hydroxy-4-(2-phenyl-butyrylamino)-benzamide DMHEQ41 MI TT6R7JZ DMHEQ41 MN Histone deacetylase 1 (HDAC1) DMHEQ41 MT DTT DMHEQ41 MA Inhibitor DMHEQ41 RN Structure-based optimization of phenylbutyrate-derived histone deacetylase inhibitors. J Med Chem. 2005 Aug 25;48(17):5530-5. DMHEQ41 RU https://pubmed.ncbi.nlm.nih.gov/16107152 DMHEQ41 DI DMHEQ41 DMHEQ41 DN N-Hydroxy-4-(2-phenyl-butyrylamino)-benzamide DMHEQ41 MI TTYHPU6 DMHEQ41 MN Histone deacetylase 10 (HDAC10) DMHEQ41 MT DTT DMHEQ41 MA Inhibitor DMHEQ41 RN Structure-based optimization of phenylbutyrate-derived histone deacetylase inhibitors. J Med Chem. 2005 Aug 25;48(17):5530-5. DMHEQ41 RU https://pubmed.ncbi.nlm.nih.gov/16107152 DMHEQ41 DI DMHEQ41 DMHEQ41 DN N-Hydroxy-4-(2-phenyl-butyrylamino)-benzamide DMHEQ41 MI TTSHTOI DMHEQ41 MN Histone deacetylase 2 (HDAC2) DMHEQ41 MT DTT DMHEQ41 MA Inhibitor DMHEQ41 RN Structure-based optimization of phenylbutyrate-derived histone deacetylase inhibitors. J Med Chem. 2005 Aug 25;48(17):5530-5. DMHEQ41 RU https://pubmed.ncbi.nlm.nih.gov/16107152 DMHEQ41 DI DMHEQ41 DMHEQ41 DN N-Hydroxy-4-(2-phenyl-butyrylamino)-benzamide DMHEQ41 MI TTTQGH8 DMHEQ41 MN Histone deacetylase 4 (HDAC4) DMHEQ41 MT DTT DMHEQ41 MA Inhibitor DMHEQ41 RN Structure-based optimization of phenylbutyrate-derived histone deacetylase inhibitors. J Med Chem. 2005 Aug 25;48(17):5530-5. DMHEQ41 RU https://pubmed.ncbi.nlm.nih.gov/16107152 DMHEQ41 DI DMHEQ41 DMHEQ41 DN N-Hydroxy-4-(2-phenyl-butyrylamino)-benzamide DMHEQ41 MI TT5ZKDI DMHEQ41 MN Histone deacetylase 6 (HDAC6) DMHEQ41 MT DTT DMHEQ41 MA Inhibitor DMHEQ41 RN Structure-based optimization of phenylbutyrate-derived histone deacetylase inhibitors. J Med Chem. 2005 Aug 25;48(17):5530-5. DMHEQ41 RU https://pubmed.ncbi.nlm.nih.gov/16107152 DMHEQ41 DI DMHEQ41 DMHEQ41 DN N-Hydroxy-4-(2-phenyl-butyrylamino)-benzamide DMHEQ41 MI TTT6LFV DMHEQ41 MN Histone deacetylase 8 (HDAC8) DMHEQ41 MT DTT DMHEQ41 MA Inhibitor DMHEQ41 RN Structure-based optimization of phenylbutyrate-derived histone deacetylase inhibitors. J Med Chem. 2005 Aug 25;48(17):5530-5. DMHEQ41 RU https://pubmed.ncbi.nlm.nih.gov/16107152 DMUOCQB DI DMUOCQB DMUOCQB DN N-Hydroxy-4-(3-phenyl-propionylamino)-benzamide DMUOCQB MI TTBH0VX DMUOCQB MN Histone deacetylase (HDAC) DMUOCQB MT DTT DMUOCQB MA Inhibitor DMUOCQB RN Structure-based optimization of phenylbutyrate-derived histone deacetylase inhibitors. J Med Chem. 2005 Aug 25;48(17):5530-5. DMUOCQB RU https://pubmed.ncbi.nlm.nih.gov/16107152 DMUOCQB DI DMUOCQB DMUOCQB DN N-Hydroxy-4-(3-phenyl-propionylamino)-benzamide DMUOCQB MI TT6R7JZ DMUOCQB MN Histone deacetylase 1 (HDAC1) DMUOCQB MT DTT DMUOCQB MA Inhibitor DMUOCQB RN Design, synthesis and preliminary biological evaluation of N-hydroxy-4-(3-phenylpropanamido)benzamide (HPPB) derivatives as novel histone deacetyla... Eur J Med Chem. 2009 Nov;44(11):4470-6. DMUOCQB RU https://pubmed.ncbi.nlm.nih.gov/19608304 DMUOCQB DI DMUOCQB DMUOCQB DN N-Hydroxy-4-(3-phenyl-propionylamino)-benzamide DMUOCQB MI TTYHPU6 DMUOCQB MN Histone deacetylase 10 (HDAC10) DMUOCQB MT DTT DMUOCQB MA Inhibitor DMUOCQB RN Structure-based optimization of phenylbutyrate-derived histone deacetylase inhibitors. J Med Chem. 2005 Aug 25;48(17):5530-5. DMUOCQB RU https://pubmed.ncbi.nlm.nih.gov/16107152 DMUOCQB DI DMUOCQB DMUOCQB DN N-Hydroxy-4-(3-phenyl-propionylamino)-benzamide DMUOCQB MI TTSHTOI DMUOCQB MN Histone deacetylase 2 (HDAC2) DMUOCQB MT DTT DMUOCQB MA Inhibitor DMUOCQB RN Design, synthesis and preliminary biological evaluation of N-hydroxy-4-(3-phenylpropanamido)benzamide (HPPB) derivatives as novel histone deacetyla... Eur J Med Chem. 2009 Nov;44(11):4470-6. DMUOCQB RU https://pubmed.ncbi.nlm.nih.gov/19608304 DMUOCQB DI DMUOCQB DMUOCQB DN N-Hydroxy-4-(3-phenyl-propionylamino)-benzamide DMUOCQB MI TTTQGH8 DMUOCQB MN Histone deacetylase 4 (HDAC4) DMUOCQB MT DTT DMUOCQB MA Inhibitor DMUOCQB RN Structure-based optimization of phenylbutyrate-derived histone deacetylase inhibitors. J Med Chem. 2005 Aug 25;48(17):5530-5. DMUOCQB RU https://pubmed.ncbi.nlm.nih.gov/16107152 DMUOCQB DI DMUOCQB DMUOCQB DN N-Hydroxy-4-(3-phenyl-propionylamino)-benzamide DMUOCQB MI TT5ZKDI DMUOCQB MN Histone deacetylase 6 (HDAC6) DMUOCQB MT DTT DMUOCQB MA Inhibitor DMUOCQB RN Structure-based optimization of phenylbutyrate-derived histone deacetylase inhibitors. J Med Chem. 2005 Aug 25;48(17):5530-5. DMUOCQB RU https://pubmed.ncbi.nlm.nih.gov/16107152 DMUOCQB DI DMUOCQB DMUOCQB DN N-Hydroxy-4-(3-phenyl-propionylamino)-benzamide DMUOCQB MI TTT6LFV DMUOCQB MN Histone deacetylase 8 (HDAC8) DMUOCQB MT DTT DMUOCQB MA Inhibitor DMUOCQB RN Structure-based optimization of phenylbutyrate-derived histone deacetylase inhibitors. J Med Chem. 2005 Aug 25;48(17):5530-5. DMUOCQB RU https://pubmed.ncbi.nlm.nih.gov/16107152 DMQN6CL DI DMQN6CL DMQN6CL DN N-Hydroxy-4-(4-methoxy-phenyl)-4-oxo-butyramide DMQN6CL MI TTMX39J DMQN6CL MN Matrix metalloproteinase-1 (MMP-1) DMQN6CL MT DTT DMQN6CL MA Inhibitor DMQN6CL RN Receptor flexibility in de novo ligand design and docking. J Med Chem. 2005 Oct 20;48(21):6585-96. DMQN6CL RU https://pubmed.ncbi.nlm.nih.gov/16220975 DMVEOBY DI DMVEOBY DMVEOBY DN N-Hydroxy-4-(4-phenyl-butyrylamino)-benzamide DMVEOBY MI TTBH0VX DMVEOBY MN Histone deacetylase (HDAC) DMVEOBY MT DTT DMVEOBY MA Inhibitor DMVEOBY RN Structure-based optimization of phenylbutyrate-derived histone deacetylase inhibitors. J Med Chem. 2005 Aug 25;48(17):5530-5. DMVEOBY RU https://pubmed.ncbi.nlm.nih.gov/16107152 DMVEOBY DI DMVEOBY DMVEOBY DN N-Hydroxy-4-(4-phenyl-butyrylamino)-benzamide DMVEOBY MI TT6R7JZ DMVEOBY MN Histone deacetylase 1 (HDAC1) DMVEOBY MT DTT DMVEOBY MA Inhibitor DMVEOBY RN Structure-based optimization of phenylbutyrate-derived histone deacetylase inhibitors. J Med Chem. 2005 Aug 25;48(17):5530-5. DMVEOBY RU https://pubmed.ncbi.nlm.nih.gov/16107152 DMVEOBY DI DMVEOBY DMVEOBY DN N-Hydroxy-4-(4-phenyl-butyrylamino)-benzamide DMVEOBY MI TTYHPU6 DMVEOBY MN Histone deacetylase 10 (HDAC10) DMVEOBY MT DTT DMVEOBY MA Inhibitor DMVEOBY RN Structure-based optimization of phenylbutyrate-derived histone deacetylase inhibitors. J Med Chem. 2005 Aug 25;48(17):5530-5. DMVEOBY RU https://pubmed.ncbi.nlm.nih.gov/16107152 DMVEOBY DI DMVEOBY DMVEOBY DN N-Hydroxy-4-(4-phenyl-butyrylamino)-benzamide DMVEOBY MI TTSHTOI DMVEOBY MN Histone deacetylase 2 (HDAC2) DMVEOBY MT DTT DMVEOBY MA Inhibitor DMVEOBY RN Structure-based optimization of phenylbutyrate-derived histone deacetylase inhibitors. J Med Chem. 2005 Aug 25;48(17):5530-5. DMVEOBY RU https://pubmed.ncbi.nlm.nih.gov/16107152 DMVEOBY DI DMVEOBY DMVEOBY DN N-Hydroxy-4-(4-phenyl-butyrylamino)-benzamide DMVEOBY MI TTTQGH8 DMVEOBY MN Histone deacetylase 4 (HDAC4) DMVEOBY MT DTT DMVEOBY MA Inhibitor DMVEOBY RN Structure-based optimization of phenylbutyrate-derived histone deacetylase inhibitors. J Med Chem. 2005 Aug 25;48(17):5530-5. DMVEOBY RU https://pubmed.ncbi.nlm.nih.gov/16107152 DMVEOBY DI DMVEOBY DMVEOBY DN N-Hydroxy-4-(4-phenyl-butyrylamino)-benzamide DMVEOBY MI TT5ZKDI DMVEOBY MN Histone deacetylase 6 (HDAC6) DMVEOBY MT DTT DMVEOBY MA Inhibitor DMVEOBY RN Structure-based optimization of phenylbutyrate-derived histone deacetylase inhibitors. J Med Chem. 2005 Aug 25;48(17):5530-5. DMVEOBY RU https://pubmed.ncbi.nlm.nih.gov/16107152 DMVEOBY DI DMVEOBY DMVEOBY DN N-Hydroxy-4-(4-phenyl-butyrylamino)-benzamide DMVEOBY MI TTT6LFV DMVEOBY MN Histone deacetylase 8 (HDAC8) DMVEOBY MT DTT DMVEOBY MA Inhibitor DMVEOBY RN Structure-based optimization of phenylbutyrate-derived histone deacetylase inhibitors. J Med Chem. 2005 Aug 25;48(17):5530-5. DMVEOBY RU https://pubmed.ncbi.nlm.nih.gov/16107152 DMISRMT DI DMISRMT DMISRMT DN N-Hydroxy-4-(5-phenyl-pentanoylamino)-benzamide DMISRMT MI TTBH0VX DMISRMT MN Histone deacetylase (HDAC) DMISRMT MT DTT DMISRMT MA Inhibitor DMISRMT RN Structure-based optimization of phenylbutyrate-derived histone deacetylase inhibitors. J Med Chem. 2005 Aug 25;48(17):5530-5. DMISRMT RU https://pubmed.ncbi.nlm.nih.gov/16107152 DMISRMT DI DMISRMT DMISRMT DN N-Hydroxy-4-(5-phenyl-pentanoylamino)-benzamide DMISRMT MI TT6R7JZ DMISRMT MN Histone deacetylase 1 (HDAC1) DMISRMT MT DTT DMISRMT MA Inhibitor DMISRMT RN Structure-based optimization of phenylbutyrate-derived histone deacetylase inhibitors. J Med Chem. 2005 Aug 25;48(17):5530-5. DMISRMT RU https://pubmed.ncbi.nlm.nih.gov/16107152 DMISRMT DI DMISRMT DMISRMT DN N-Hydroxy-4-(5-phenyl-pentanoylamino)-benzamide DMISRMT MI TTYHPU6 DMISRMT MN Histone deacetylase 10 (HDAC10) DMISRMT MT DTT DMISRMT MA Inhibitor DMISRMT RN Structure-based optimization of phenylbutyrate-derived histone deacetylase inhibitors. J Med Chem. 2005 Aug 25;48(17):5530-5. DMISRMT RU https://pubmed.ncbi.nlm.nih.gov/16107152 DMISRMT DI DMISRMT DMISRMT DN N-Hydroxy-4-(5-phenyl-pentanoylamino)-benzamide DMISRMT MI TTSHTOI DMISRMT MN Histone deacetylase 2 (HDAC2) DMISRMT MT DTT DMISRMT MA Inhibitor DMISRMT RN Structure-based optimization of phenylbutyrate-derived histone deacetylase inhibitors. J Med Chem. 2005 Aug 25;48(17):5530-5. DMISRMT RU https://pubmed.ncbi.nlm.nih.gov/16107152 DMISRMT DI DMISRMT DMISRMT DN N-Hydroxy-4-(5-phenyl-pentanoylamino)-benzamide DMISRMT MI TTTQGH8 DMISRMT MN Histone deacetylase 4 (HDAC4) DMISRMT MT DTT DMISRMT MA Inhibitor DMISRMT RN Structure-based optimization of phenylbutyrate-derived histone deacetylase inhibitors. J Med Chem. 2005 Aug 25;48(17):5530-5. DMISRMT RU https://pubmed.ncbi.nlm.nih.gov/16107152 DMISRMT DI DMISRMT DMISRMT DN N-Hydroxy-4-(5-phenyl-pentanoylamino)-benzamide DMISRMT MI TT5ZKDI DMISRMT MN Histone deacetylase 6 (HDAC6) DMISRMT MT DTT DMISRMT MA Inhibitor DMISRMT RN Structure-based optimization of phenylbutyrate-derived histone deacetylase inhibitors. J Med Chem. 2005 Aug 25;48(17):5530-5. DMISRMT RU https://pubmed.ncbi.nlm.nih.gov/16107152 DMISRMT DI DMISRMT DMISRMT DN N-Hydroxy-4-(5-phenyl-pentanoylamino)-benzamide DMISRMT MI TTT6LFV DMISRMT MN Histone deacetylase 8 (HDAC8) DMISRMT MT DTT DMISRMT MA Inhibitor DMISRMT RN Structure-based optimization of phenylbutyrate-derived histone deacetylase inhibitors. J Med Chem. 2005 Aug 25;48(17):5530-5. DMISRMT RU https://pubmed.ncbi.nlm.nih.gov/16107152 DMSHQE3 DI DMSHQE3 DMSHQE3 DN N-hydroxy-4-(naphthalen-1-yl)benzamide DMSHQE3 MI TT2J34L DMSHQE3 MN Arachidonate 5-lipoxygenase (5-LOX) DMSHQE3 MT DTT DMSHQE3 MA Inhibitor DMSHQE3 RN Hydroxamic acid inhibitors of 5-lipoxygenase: quantitative structure-activity relationships. J Med Chem. 1990 Mar;33(3):992-8. DMSHQE3 RU https://pubmed.ncbi.nlm.nih.gov/2308149 DMSHQE3 DI DMSHQE3 DMSHQE3 DN N-hydroxy-4-(naphthalen-1-yl)benzamide DMSHQE3 MI TTT6LFV DMSHQE3 MN Histone deacetylase 8 (HDAC8) DMSHQE3 MT DTT DMSHQE3 MA Inhibitor DMSHQE3 RN Design and evaluation of 'Linkerless' hydroxamic acids as selective HDAC8 inhibitors. Bioorg Med Chem Lett. 2007 May 15;17(10):2874-8. DMSHQE3 RU https://pubmed.ncbi.nlm.nih.gov/17346959 DMUSHZK DI DMUSHZK DMUSHZK DN N-hydroxy-4-(oleamidomethyl)benzamide DMUSHZK MI TTIQSC1 DMUSHZK MN Bacterial Lethal factor (Bact lef) DMUSHZK MT DTT DMUSHZK MA Inhibitor DMUSHZK RN Inhibitors of anthrax lethal factor based upon N-oleoyldopamine. Bioorg Med Chem Lett. 2008 Apr 1;18(7):2467-70. DMUSHZK RU https://pubmed.ncbi.nlm.nih.gov/18314330 DMGTNQY DI DMGTNQY DMGTNQY DN N-Hydroxy-4-(pentanoylamino-methyl)-benzamide DMGTNQY MI TTBH0VX DMGTNQY MN Histone deacetylase (HDAC) DMGTNQY MT DTT DMGTNQY MA Inhibitor DMGTNQY RN Zn2+-chelating motif-tethered short-chain fatty acids as a novel class of histone deacetylase inhibitors. J Med Chem. 2004 Jan 15;47(2):467-74. DMGTNQY RU https://pubmed.ncbi.nlm.nih.gov/14711316 DMGTNQY DI DMGTNQY DMGTNQY DN N-Hydroxy-4-(pentanoylamino-methyl)-benzamide DMGTNQY MI TT6R7JZ DMGTNQY MN Histone deacetylase 1 (HDAC1) DMGTNQY MT DTT DMGTNQY MA Inhibitor DMGTNQY RN Zn2+-chelating motif-tethered short-chain fatty acids as a novel class of histone deacetylase inhibitors. J Med Chem. 2004 Jan 15;47(2):467-74. DMGTNQY RU https://pubmed.ncbi.nlm.nih.gov/14711316 DMGTNQY DI DMGTNQY DMGTNQY DN N-Hydroxy-4-(pentanoylamino-methyl)-benzamide DMGTNQY MI TTYHPU6 DMGTNQY MN Histone deacetylase 10 (HDAC10) DMGTNQY MT DTT DMGTNQY MA Inhibitor DMGTNQY RN Zn2+-chelating motif-tethered short-chain fatty acids as a novel class of histone deacetylase inhibitors. J Med Chem. 2004 Jan 15;47(2):467-74. DMGTNQY RU https://pubmed.ncbi.nlm.nih.gov/14711316 DMGTNQY DI DMGTNQY DMGTNQY DN N-Hydroxy-4-(pentanoylamino-methyl)-benzamide DMGTNQY MI TTSHTOI DMGTNQY MN Histone deacetylase 2 (HDAC2) DMGTNQY MT DTT DMGTNQY MA Inhibitor DMGTNQY RN Zn2+-chelating motif-tethered short-chain fatty acids as a novel class of histone deacetylase inhibitors. J Med Chem. 2004 Jan 15;47(2):467-74. DMGTNQY RU https://pubmed.ncbi.nlm.nih.gov/14711316 DMGTNQY DI DMGTNQY DMGTNQY DN N-Hydroxy-4-(pentanoylamino-methyl)-benzamide DMGTNQY MI TTTQGH8 DMGTNQY MN Histone deacetylase 4 (HDAC4) DMGTNQY MT DTT DMGTNQY MA Inhibitor DMGTNQY RN Zn2+-chelating motif-tethered short-chain fatty acids as a novel class of histone deacetylase inhibitors. J Med Chem. 2004 Jan 15;47(2):467-74. DMGTNQY RU https://pubmed.ncbi.nlm.nih.gov/14711316 DMGTNQY DI DMGTNQY DMGTNQY DN N-Hydroxy-4-(pentanoylamino-methyl)-benzamide DMGTNQY MI TT5ZKDI DMGTNQY MN Histone deacetylase 6 (HDAC6) DMGTNQY MT DTT DMGTNQY MA Inhibitor DMGTNQY RN Zn2+-chelating motif-tethered short-chain fatty acids as a novel class of histone deacetylase inhibitors. J Med Chem. 2004 Jan 15;47(2):467-74. DMGTNQY RU https://pubmed.ncbi.nlm.nih.gov/14711316 DMGTNQY DI DMGTNQY DMGTNQY DN N-Hydroxy-4-(pentanoylamino-methyl)-benzamide DMGTNQY MI TTT6LFV DMGTNQY MN Histone deacetylase 8 (HDAC8) DMGTNQY MT DTT DMGTNQY MA Inhibitor DMGTNQY RN Zn2+-chelating motif-tethered short-chain fatty acids as a novel class of histone deacetylase inhibitors. J Med Chem. 2004 Jan 15;47(2):467-74. DMGTNQY RU https://pubmed.ncbi.nlm.nih.gov/14711316 DMDUOH4 DI DMDUOH4 DMDUOH4 DN N-Hydroxy-4-(phenylacetylamino-methyl)-benzamide DMDUOH4 MI TTBH0VX DMDUOH4 MN Histone deacetylase (HDAC) DMDUOH4 MT DTT DMDUOH4 MA Inhibitor DMDUOH4 RN Zn2+-chelating motif-tethered short-chain fatty acids as a novel class of histone deacetylase inhibitors. J Med Chem. 2004 Jan 15;47(2):467-74. DMDUOH4 RU https://pubmed.ncbi.nlm.nih.gov/14711316 DMDUOH4 DI DMDUOH4 DMDUOH4 DN N-Hydroxy-4-(phenylacetylamino-methyl)-benzamide DMDUOH4 MI TT6R7JZ DMDUOH4 MN Histone deacetylase 1 (HDAC1) DMDUOH4 MT DTT DMDUOH4 MA Inhibitor DMDUOH4 RN Zn2+-chelating motif-tethered short-chain fatty acids as a novel class of histone deacetylase inhibitors. J Med Chem. 2004 Jan 15;47(2):467-74. DMDUOH4 RU https://pubmed.ncbi.nlm.nih.gov/14711316 DMDUOH4 DI DMDUOH4 DMDUOH4 DN N-Hydroxy-4-(phenylacetylamino-methyl)-benzamide DMDUOH4 MI TTYHPU6 DMDUOH4 MN Histone deacetylase 10 (HDAC10) DMDUOH4 MT DTT DMDUOH4 MA Inhibitor DMDUOH4 RN Zn2+-chelating motif-tethered short-chain fatty acids as a novel class of histone deacetylase inhibitors. J Med Chem. 2004 Jan 15;47(2):467-74. DMDUOH4 RU https://pubmed.ncbi.nlm.nih.gov/14711316 DMDUOH4 DI DMDUOH4 DMDUOH4 DN N-Hydroxy-4-(phenylacetylamino-methyl)-benzamide DMDUOH4 MI TTSHTOI DMDUOH4 MN Histone deacetylase 2 (HDAC2) DMDUOH4 MT DTT DMDUOH4 MA Inhibitor DMDUOH4 RN Zn2+-chelating motif-tethered short-chain fatty acids as a novel class of histone deacetylase inhibitors. J Med Chem. 2004 Jan 15;47(2):467-74. DMDUOH4 RU https://pubmed.ncbi.nlm.nih.gov/14711316 DMDUOH4 DI DMDUOH4 DMDUOH4 DN N-Hydroxy-4-(phenylacetylamino-methyl)-benzamide DMDUOH4 MI TTTQGH8 DMDUOH4 MN Histone deacetylase 4 (HDAC4) DMDUOH4 MT DTT DMDUOH4 MA Inhibitor DMDUOH4 RN Zn2+-chelating motif-tethered short-chain fatty acids as a novel class of histone deacetylase inhibitors. J Med Chem. 2004 Jan 15;47(2):467-74. DMDUOH4 RU https://pubmed.ncbi.nlm.nih.gov/14711316 DMDUOH4 DI DMDUOH4 DMDUOH4 DN N-Hydroxy-4-(phenylacetylamino-methyl)-benzamide DMDUOH4 MI TT5ZKDI DMDUOH4 MN Histone deacetylase 6 (HDAC6) DMDUOH4 MT DTT DMDUOH4 MA Inhibitor DMDUOH4 RN Zn2+-chelating motif-tethered short-chain fatty acids as a novel class of histone deacetylase inhibitors. J Med Chem. 2004 Jan 15;47(2):467-74. DMDUOH4 RU https://pubmed.ncbi.nlm.nih.gov/14711316 DMDUOH4 DI DMDUOH4 DMDUOH4 DN N-Hydroxy-4-(phenylacetylamino-methyl)-benzamide DMDUOH4 MI TTT6LFV DMDUOH4 MN Histone deacetylase 8 (HDAC8) DMDUOH4 MT DTT DMDUOH4 MA Inhibitor DMDUOH4 RN Zn2+-chelating motif-tethered short-chain fatty acids as a novel class of histone deacetylase inhibitors. J Med Chem. 2004 Jan 15;47(2):467-74. DMDUOH4 RU https://pubmed.ncbi.nlm.nih.gov/14711316 DMEO7L5 DI DMEO7L5 DMEO7L5 DN N-Hydroxy-4-iodo-benzamide DMEO7L5 MI TT2J34L DMEO7L5 MN Arachidonate 5-lipoxygenase (5-LOX) DMEO7L5 MT DTT DMEO7L5 MA Inhibitor DMEO7L5 RN Hydroxamic acid inhibitors of 5-lipoxygenase: quantitative structure-activity relationships. J Med Chem. 1990 Mar;33(3):992-8. DMEO7L5 RU https://pubmed.ncbi.nlm.nih.gov/2308149 DM16G80 DI DM16G80 DM16G80 DN N-Hydroxy-4-isobutyl-benzamide DM16G80 MI TT2J34L DM16G80 MN Arachidonate 5-lipoxygenase (5-LOX) DM16G80 MT DTT DM16G80 MA Inhibitor DM16G80 RN Hydroxamic acid inhibitors of 5-lipoxygenase: quantitative structure-activity relationships. J Med Chem. 1990 Mar;33(3):992-8. DM16G80 RU https://pubmed.ncbi.nlm.nih.gov/2308149 DMMHQE8 DI DMMHQE8 DMMHQE8 DN N-Hydroxy-4-naphthalen-2-yl-benzamide DMMHQE8 MI TT2J34L DMMHQE8 MN Arachidonate 5-lipoxygenase (5-LOX) DMMHQE8 MT DTT DMMHQE8 MA Inhibitor DMMHQE8 RN Hydroxamic acid inhibitors of 5-lipoxygenase: quantitative structure-activity relationships. J Med Chem. 1990 Mar;33(3):992-8. DMMHQE8 RU https://pubmed.ncbi.nlm.nih.gov/2308149 DMQSWO8 DI DMQSWO8 DMQSWO8 DN N-Hydroxy-4-oxo-4-(4-phenoxy-phenyl)-butyramide DMQSWO8 MI TTMX39J DMQSWO8 MN Matrix metalloproteinase-1 (MMP-1) DMQSWO8 MT DTT DMQSWO8 MA Inhibitor DMQSWO8 RN Receptor flexibility in de novo ligand design and docking. J Med Chem. 2005 Oct 20;48(21):6585-96. DMQSWO8 RU https://pubmed.ncbi.nlm.nih.gov/16220975 DMCRU17 DI DMCRU17 DMCRU17 DN N-Hydroxy-4-phenylacetylamino-benzamide DMCRU17 MI TTBH0VX DMCRU17 MN Histone deacetylase (HDAC) DMCRU17 MT DTT DMCRU17 MA Inhibitor DMCRU17 RN Structure-based optimization of phenylbutyrate-derived histone deacetylase inhibitors. J Med Chem. 2005 Aug 25;48(17):5530-5. DMCRU17 RU https://pubmed.ncbi.nlm.nih.gov/16107152 DMCRU17 DI DMCRU17 DMCRU17 DN N-Hydroxy-4-phenylacetylamino-benzamide DMCRU17 MI TT6R7JZ DMCRU17 MN Histone deacetylase 1 (HDAC1) DMCRU17 MT DTT DMCRU17 MA Inhibitor DMCRU17 RN Structure-based optimization of phenylbutyrate-derived histone deacetylase inhibitors. J Med Chem. 2005 Aug 25;48(17):5530-5. DMCRU17 RU https://pubmed.ncbi.nlm.nih.gov/16107152 DMCRU17 DI DMCRU17 DMCRU17 DN N-Hydroxy-4-phenylacetylamino-benzamide DMCRU17 MI TTYHPU6 DMCRU17 MN Histone deacetylase 10 (HDAC10) DMCRU17 MT DTT DMCRU17 MA Inhibitor DMCRU17 RN Structure-based optimization of phenylbutyrate-derived histone deacetylase inhibitors. J Med Chem. 2005 Aug 25;48(17):5530-5. DMCRU17 RU https://pubmed.ncbi.nlm.nih.gov/16107152 DMCRU17 DI DMCRU17 DMCRU17 DN N-Hydroxy-4-phenylacetylamino-benzamide DMCRU17 MI TTSHTOI DMCRU17 MN Histone deacetylase 2 (HDAC2) DMCRU17 MT DTT DMCRU17 MA Inhibitor DMCRU17 RN Structure-based optimization of phenylbutyrate-derived histone deacetylase inhibitors. J Med Chem. 2005 Aug 25;48(17):5530-5. DMCRU17 RU https://pubmed.ncbi.nlm.nih.gov/16107152 DMCRU17 DI DMCRU17 DMCRU17 DN N-Hydroxy-4-phenylacetylamino-benzamide DMCRU17 MI TTTQGH8 DMCRU17 MN Histone deacetylase 4 (HDAC4) DMCRU17 MT DTT DMCRU17 MA Inhibitor DMCRU17 RN Structure-based optimization of phenylbutyrate-derived histone deacetylase inhibitors. J Med Chem. 2005 Aug 25;48(17):5530-5. DMCRU17 RU https://pubmed.ncbi.nlm.nih.gov/16107152 DMCRU17 DI DMCRU17 DMCRU17 DN N-Hydroxy-4-phenylacetylamino-benzamide DMCRU17 MI TT5ZKDI DMCRU17 MN Histone deacetylase 6 (HDAC6) DMCRU17 MT DTT DMCRU17 MA Inhibitor DMCRU17 RN Structure-based optimization of phenylbutyrate-derived histone deacetylase inhibitors. J Med Chem. 2005 Aug 25;48(17):5530-5. DMCRU17 RU https://pubmed.ncbi.nlm.nih.gov/16107152 DMCRU17 DI DMCRU17 DMCRU17 DN N-Hydroxy-4-phenylacetylamino-benzamide DMCRU17 MI TTT6LFV DMCRU17 MN Histone deacetylase 8 (HDAC8) DMCRU17 MT DTT DMCRU17 MA Inhibitor DMCRU17 RN Structure-based optimization of phenylbutyrate-derived histone deacetylase inhibitors. J Med Chem. 2005 Aug 25;48(17):5530-5. DMCRU17 RU https://pubmed.ncbi.nlm.nih.gov/16107152 DMYKJZ2 DI DMYKJZ2 DMYKJZ2 DN N-hydroxy-5-(pyridin-2-yl)thiophene-2-carboxamide DMYKJZ2 MI TT6R7JZ DMYKJZ2 MN Histone deacetylase 1 (HDAC1) DMYKJZ2 MT DTT DMYKJZ2 MA Inhibitor DMYKJZ2 RN Identification and optimisation of a series of substituted 5-pyridin-2-yl-thiophene-2-hydroxamic acids as potent histone deacetylase (HDAC) inhibit... Bioorg Med Chem Lett. 2007 Jan 15;17(2):363-9. DMYKJZ2 RU https://pubmed.ncbi.nlm.nih.gov/17107790 DMK98LE DI DMK98LE DMK98LE DN N-hydroxy-5-(pyridin-3-yl)thiophene-2-carboxamide DMK98LE MI TT6R7JZ DMK98LE MN Histone deacetylase 1 (HDAC1) DMK98LE MT DTT DMK98LE MA Inhibitor DMK98LE RN Identification and optimisation of a series of substituted 5-pyridin-2-yl-thiophene-2-hydroxamic acids as potent histone deacetylase (HDAC) inhibit... Bioorg Med Chem Lett. 2007 Jan 15;17(2):363-9. DMK98LE RU https://pubmed.ncbi.nlm.nih.gov/17107790 DM653RM DI DM653RM DM653RM DN N-hydroxy-5-(pyridin-4-yl)thiophene-2-carboxamide DM653RM MI TT6R7JZ DM653RM MN Histone deacetylase 1 (HDAC1) DM653RM MT DTT DM653RM MA Inhibitor DM653RM RN Identification and optimisation of a series of substituted 5-pyridin-2-yl-thiophene-2-hydroxamic acids as potent histone deacetylase (HDAC) inhibit... Bioorg Med Chem Lett. 2007 Jan 15;17(2):363-9. DM653RM RU https://pubmed.ncbi.nlm.nih.gov/17107790 DMA2WUQ DI DMA2WUQ DMA2WUQ DN N-hydroxy-5-phenylthiophene-2-carboxamide DMA2WUQ MI TT6R7JZ DMA2WUQ MN Histone deacetylase 1 (HDAC1) DMA2WUQ MT DTT DMA2WUQ MA Inhibitor DMA2WUQ RN Identification and optimisation of a series of substituted 5-pyridin-2-yl-thiophene-2-hydroxamic acids as potent histone deacetylase (HDAC) inhibit... Bioorg Med Chem Lett. 2007 Jan 15;17(2):363-9. DMA2WUQ RU https://pubmed.ncbi.nlm.nih.gov/17107790 DM0JNO2 DI DM0JNO2 DM0JNO2 DN N-hydroxy-6-oxo-6-phenylhexanamide DM0JNO2 MI TT6R7JZ DM0JNO2 MN Histone deacetylase 1 (HDAC1) DM0JNO2 MT DTT DM0JNO2 MA Inhibitor DM0JNO2 RN 3D-QSAR studies of HDACs inhibitors using pharmacophore-based alignment. Eur J Med Chem. 2009 Jul;44(7):2868-76. DM0JNO2 RU https://pubmed.ncbi.nlm.nih.gov/19136179 DMUXZL1 DI DMUXZL1 DMUXZL1 DN N-hydroxy-7-(4-methoxyphenyl)-7-oxoheptanamide DMUXZL1 MI TT6R7JZ DMUXZL1 MN Histone deacetylase 1 (HDAC1) DMUXZL1 MT DTT DMUXZL1 MA Inhibitor DMUXZL1 RN 3D-QSAR studies of HDACs inhibitors using pharmacophore-based alignment. Eur J Med Chem. 2009 Jul;44(7):2868-76. DMUXZL1 RU https://pubmed.ncbi.nlm.nih.gov/19136179 DM8Z4L0 DI DM8Z4L0 DM8Z4L0 DN N-hydroxy-7-(naphthalen-2-yl)-7-oxoheptanamide DM8Z4L0 MI TT6R7JZ DM8Z4L0 MN Histone deacetylase 1 (HDAC1) DM8Z4L0 MT DTT DM8Z4L0 MA Inhibitor DM8Z4L0 RN 3D-QSAR studies of HDACs inhibitors using pharmacophore-based alignment. Eur J Med Chem. 2009 Jul;44(7):2868-76. DM8Z4L0 RU https://pubmed.ncbi.nlm.nih.gov/19136179 DMBUNAP DI DMBUNAP DMBUNAP DN N-hydroxy-7-(naphthalen-2-yloxy)heptanamide DMBUNAP MI TT6R7JZ DMBUNAP MN Histone deacetylase 1 (HDAC1) DMBUNAP MT DTT DMBUNAP MA Inhibitor DMBUNAP RN Structure-activity relationships of aryloxyalkanoic acid hydroxyamides as potent inhibitors of histone deacetylase. Bioorg Med Chem Lett. 2007 Jan 1;17(1):136-41. DMBUNAP RU https://pubmed.ncbi.nlm.nih.gov/17046252 DMQW7JZ DI DMQW7JZ DMQW7JZ DN N-hydroxy-7-oxo-7-phenylheptanamide DMQW7JZ MI TT6R7JZ DMQW7JZ MN Histone deacetylase 1 (HDAC1) DMQW7JZ MT DTT DMQW7JZ MA Inhibitor DMQW7JZ RN 3D-QSAR studies of HDACs inhibitors using pharmacophore-based alignment. Eur J Med Chem. 2009 Jul;44(7):2868-76. DMQW7JZ RU https://pubmed.ncbi.nlm.nih.gov/19136179 DMSIMNR DI DMSIMNR DMSIMNR DN N-hydroxy-8-(2-methoxyphenyl)-8-oxooctanamide DMSIMNR MI TT6R7JZ DMSIMNR MN Histone deacetylase 1 (HDAC1) DMSIMNR MT DTT DMSIMNR MA Inhibitor DMSIMNR RN 3D-QSAR studies of HDACs inhibitors using pharmacophore-based alignment. Eur J Med Chem. 2009 Jul;44(7):2868-76. DMSIMNR RU https://pubmed.ncbi.nlm.nih.gov/19136179 DMD2K4T DI DMD2K4T DMD2K4T DN N-hydroxy-8-(4-methoxyphenyl)-8-oxooctanamide DMD2K4T MI TT6R7JZ DMD2K4T MN Histone deacetylase 1 (HDAC1) DMD2K4T MT DTT DMD2K4T MA Inhibitor DMD2K4T RN 3D-QSAR studies of HDACs inhibitors using pharmacophore-based alignment. Eur J Med Chem. 2009 Jul;44(7):2868-76. DMD2K4T RU https://pubmed.ncbi.nlm.nih.gov/19136179 DMRN1C6 DI DMRN1C6 DMRN1C6 DN N-hydroxy-8-(naphthalen-2-yl)non-8-enamide DMRN1C6 MI TT6R7JZ DMRN1C6 MN Histone deacetylase 1 (HDAC1) DMRN1C6 MT DTT DMRN1C6 MA Inhibitor DMRN1C6 RN 3D-QSAR studies of HDACs inhibitors using pharmacophore-based alignment. Eur J Med Chem. 2009 Jul;44(7):2868-76. DMRN1C6 RU https://pubmed.ncbi.nlm.nih.gov/19136179 DMGZY1Q DI DMGZY1Q DMGZY1Q DN N-hydroxy-8-(naphthalen-2-yl)oct-7-enamide DMGZY1Q MI TT6R7JZ DMGZY1Q MN Histone deacetylase 1 (HDAC1) DMGZY1Q MT DTT DMGZY1Q MA Inhibitor DMGZY1Q RN 3D-QSAR studies of HDACs inhibitors using pharmacophore-based alignment. Eur J Med Chem. 2009 Jul;44(7):2868-76. DMGZY1Q RU https://pubmed.ncbi.nlm.nih.gov/19136179 DMXQICK DI DMXQICK DMXQICK DN N-hydroxy-8-(naphthalen-2-yl)octanamide DMXQICK MI TT6R7JZ DMXQICK MN Histone deacetylase 1 (HDAC1) DMXQICK MT DTT DMXQICK MA Inhibitor DMXQICK RN 3D-QSAR studies of HDACs inhibitors using pharmacophore-based alignment. Eur J Med Chem. 2009 Jul;44(7):2868-76. DMXQICK RU https://pubmed.ncbi.nlm.nih.gov/19136179 DMO4CR7 DI DMO4CR7 DMO4CR7 DN N-hydroxy-8-oxo-8-(pyridin-3-yl)octanamide DMO4CR7 MI TT6R7JZ DMO4CR7 MN Histone deacetylase 1 (HDAC1) DMO4CR7 MT DTT DMO4CR7 MA Inhibitor DMO4CR7 RN 3D-QSAR studies of HDACs inhibitors using pharmacophore-based alignment. Eur J Med Chem. 2009 Jul;44(7):2868-76. DMO4CR7 RU https://pubmed.ncbi.nlm.nih.gov/19136179 DMID3BF DI DMID3BF DMID3BF DN N-hydroxy-9,10-dihydroanthracene-9-carboxamide DMID3BF MI TTBH0VX DMID3BF MN Histone deacetylase (HDAC) DMID3BF MT DTT DMID3BF MA Inhibitor DMID3BF RN Diphenylmethylene hydroxamic acids as selective class IIa histone deacetylase inhibitors. Bioorg Med Chem Lett. 2009 Oct 1;19(19):5684-8. DMID3BF RU https://pubmed.ncbi.nlm.nih.gov/19699639 DMID3BF DI DMID3BF DMID3BF DN N-hydroxy-9,10-dihydroanthracene-9-carboxamide DMID3BF MI TTTQGH8 DMID3BF MN Histone deacetylase 4 (HDAC4) DMID3BF MT DTT DMID3BF MA Inhibitor DMID3BF RN Diphenylmethylene hydroxamic acids as selective class IIa histone deacetylase inhibitors. Bioorg Med Chem Lett. 2009 Oct 1;19(19):5684-8. DMID3BF RU https://pubmed.ncbi.nlm.nih.gov/19699639 DM0DRHP DI DM0DRHP DM0DRHP DN N-hydroxy-9H-xanthene-9-carboxamide DM0DRHP MI TTBH0VX DM0DRHP MN Histone deacetylase (HDAC) DM0DRHP MT DTT DM0DRHP MA Inhibitor DM0DRHP RN Diphenylmethylene hydroxamic acids as selective class IIa histone deacetylase inhibitors. Bioorg Med Chem Lett. 2009 Oct 1;19(19):5684-8. DM0DRHP RU https://pubmed.ncbi.nlm.nih.gov/19699639 DM0DRHP DI DM0DRHP DM0DRHP DN N-hydroxy-9H-xanthene-9-carboxamide DM0DRHP MI TTTQGH8 DM0DRHP MN Histone deacetylase 4 (HDAC4) DM0DRHP MT DTT DM0DRHP MA Inhibitor DM0DRHP RN Diphenylmethylene hydroxamic acids as selective class IIa histone deacetylase inhibitors. Bioorg Med Chem Lett. 2009 Oct 1;19(19):5684-8. DM0DRHP RU https://pubmed.ncbi.nlm.nih.gov/19699639 DMIC2A8 DI DMIC2A8 DMIC2A8 DN N-hydroxy-9-oxo-9-phenylnonanamide DMIC2A8 MI TT6R7JZ DMIC2A8 MN Histone deacetylase 1 (HDAC1) DMIC2A8 MT DTT DMIC2A8 MA Inhibitor DMIC2A8 RN 3D-QSAR studies of HDACs inhibitors using pharmacophore-based alignment. Eur J Med Chem. 2009 Jul;44(7):2868-76. DMIC2A8 RU https://pubmed.ncbi.nlm.nih.gov/19136179 DMR4J8G DI DMR4J8G DMR4J8G DN N-hydroxybenzo[b]thiophene-2-carboxamide DMR4J8G MI TT6R7JZ DMR4J8G MN Histone deacetylase 1 (HDAC1) DMR4J8G MT DTT DMR4J8G MA Inhibitor DMR4J8G RN Histone deacetylase inhibitors: from bench to clinic. J Med Chem. 2008 Mar 27;51(6):1505-29. DMR4J8G RU https://pubmed.ncbi.nlm.nih.gov/18247554 DM41JIB DI DM41JIB DM41JIB DN N-Hydroxycarbamoylmethyl-4-methoxy-benzamide DM41JIB MI TTMX39J DM41JIB MN Matrix metalloproteinase-1 (MMP-1) DM41JIB MT DTT DM41JIB MA Inhibitor DM41JIB RN Receptor flexibility in de novo ligand design and docking. J Med Chem. 2005 Oct 20;48(21):6585-96. DM41JIB RU https://pubmed.ncbi.nlm.nih.gov/16220975 DMDTX4L DI DMDTX4L DMDTX4L DN N-Hydroxycarbamoylmethyl-4-phenoxy-benzamide DMDTX4L MI TTMX39J DMDTX4L MN Matrix metalloproteinase-1 (MMP-1) DMDTX4L MT DTT DMDTX4L MA Inhibitor DMDTX4L RN Receptor flexibility in de novo ligand design and docking. J Med Chem. 2005 Oct 20;48(21):6585-96. DMDTX4L RU https://pubmed.ncbi.nlm.nih.gov/16220975 DM3J5MR DI DM3J5MR DM3J5MR DN N-Hydroxy-E-3-(4'-chlorobiphenyl-4-yl)-acrylamide DM3J5MR MI TTSHTOI DM3J5MR MN Histone deacetylase 2 (HDAC2) DM3J5MR MT DTT DM3J5MR MA Inhibitor DM3J5MR RN Design, synthesis, and evaluation of biphenyl-4-yl-acrylohydroxamic acid derivatives as histone deacetylase (HDAC) inhibitors. Eur J Med Chem. 2009 May;44(5):1900-12. DM3J5MR RU https://pubmed.ncbi.nlm.nih.gov/19084294 DMVFKO4 DI DMVFKO4 DMVFKO4 DN N-Hydroxy-E-3-(4'-cyanobiphenyl-4-yl)-acrylamide DMVFKO4 MI TTSHTOI DMVFKO4 MN Histone deacetylase 2 (HDAC2) DMVFKO4 MT DTT DMVFKO4 MA Inhibitor DMVFKO4 RN Design, synthesis, and evaluation of biphenyl-4-yl-acrylohydroxamic acid derivatives as histone deacetylase (HDAC) inhibitors. Eur J Med Chem. 2009 May;44(5):1900-12. DMVFKO4 RU https://pubmed.ncbi.nlm.nih.gov/19084294 DMQCK5G DI DMQCK5G DMQCK5G DN N-Hydroxy-E-3-(biphenyl-4-yl)-acrylamide DMQCK5G MI TTSHTOI DMQCK5G MN Histone deacetylase 2 (HDAC2) DMQCK5G MT DTT DMQCK5G MA Inhibitor DMQCK5G RN Design, synthesis, and evaluation of biphenyl-4-yl-acrylohydroxamic acid derivatives as histone deacetylase (HDAC) inhibitors. Eur J Med Chem. 2009 May;44(5):1900-12. DMQCK5G RU https://pubmed.ncbi.nlm.nih.gov/19084294 DM865Y2 DI DM865Y2 DM865Y2 DN N-Hydroxy-N'-(2-methylphenyl)octanediamide DM865Y2 MI TTBH0VX DM865Y2 MN Histone deacetylase (HDAC) DM865Y2 MT DTT DM865Y2 MA Inhibitor DM865Y2 RN Biological and biophysical properties of the histone deacetylase inhibitor suberoylanilide hydroxamic acid are affected by the presence of short al... J Med Chem. 2010 Mar 11;53(5):1937-50. DM865Y2 RU https://pubmed.ncbi.nlm.nih.gov/20143840 DM865Y2 DI DM865Y2 DM865Y2 DN N-Hydroxy-N'-(2-methylphenyl)octanediamide DM865Y2 MI TT6R7JZ DM865Y2 MN Histone deacetylase 1 (HDAC1) DM865Y2 MT DTT DM865Y2 MA Inhibitor DM865Y2 RN Biological and biophysical properties of the histone deacetylase inhibitor suberoylanilide hydroxamic acid are affected by the presence of short al... J Med Chem. 2010 Mar 11;53(5):1937-50. DM865Y2 RU https://pubmed.ncbi.nlm.nih.gov/20143840 DMYRC2M DI DMYRC2M DMYRC2M DN N-Hydroxy-N'-(3-methylphenyl)octanediamide DMYRC2M MI TTBH0VX DMYRC2M MN Histone deacetylase (HDAC) DMYRC2M MT DTT DMYRC2M MA Inhibitor DMYRC2M RN Biological and biophysical properties of the histone deacetylase inhibitor suberoylanilide hydroxamic acid are affected by the presence of short al... J Med Chem. 2010 Mar 11;53(5):1937-50. DMYRC2M RU https://pubmed.ncbi.nlm.nih.gov/20143840 DMYRC2M DI DMYRC2M DMYRC2M DN N-Hydroxy-N'-(3-methylphenyl)octanediamide DMYRC2M MI TT6R7JZ DMYRC2M MN Histone deacetylase 1 (HDAC1) DMYRC2M MT DTT DMYRC2M MA Inhibitor DMYRC2M RN Biological and biophysical properties of the histone deacetylase inhibitor suberoylanilide hydroxamic acid are affected by the presence of short al... J Med Chem. 2010 Mar 11;53(5):1937-50. DMYRC2M RU https://pubmed.ncbi.nlm.nih.gov/20143840 DMELB07 DI DMELB07 DMELB07 DN N-Hydroxy-N'-(4-methoxyphenyl)octanediamide DMELB07 MI TTBH0VX DMELB07 MN Histone deacetylase (HDAC) DMELB07 MT DTT DMELB07 MA Inhibitor DMELB07 RN Biological and biophysical properties of the histone deacetylase inhibitor suberoylanilide hydroxamic acid are affected by the presence of short al... J Med Chem. 2010 Mar 11;53(5):1937-50. DMELB07 RU https://pubmed.ncbi.nlm.nih.gov/20143840 DMELB07 DI DMELB07 DMELB07 DN N-Hydroxy-N'-(4-methoxyphenyl)octanediamide DMELB07 MI TT6R7JZ DMELB07 MN Histone deacetylase 1 (HDAC1) DMELB07 MT DTT DMELB07 MA Inhibitor DMELB07 RN Biological and biophysical properties of the histone deacetylase inhibitor suberoylanilide hydroxamic acid are affected by the presence of short al... J Med Chem. 2010 Mar 11;53(5):1937-50. DMELB07 RU https://pubmed.ncbi.nlm.nih.gov/20143840 DM3DPZ8 DI DM3DPZ8 DM3DPZ8 DN N-Hydroxy-N'-(4-methylphenyl)octanediamide DM3DPZ8 MI TTBH0VX DM3DPZ8 MN Histone deacetylase (HDAC) DM3DPZ8 MT DTT DM3DPZ8 MA Inhibitor DM3DPZ8 RN Biological and biophysical properties of the histone deacetylase inhibitor suberoylanilide hydroxamic acid are affected by the presence of short al... J Med Chem. 2010 Mar 11;53(5):1937-50. DM3DPZ8 RU https://pubmed.ncbi.nlm.nih.gov/20143840 DM3DPZ8 DI DM3DPZ8 DM3DPZ8 DN N-Hydroxy-N'-(4-methylphenyl)octanediamide DM3DPZ8 MI TT6R7JZ DM3DPZ8 MN Histone deacetylase 1 (HDAC1) DM3DPZ8 MT DTT DM3DPZ8 MA Inhibitor DM3DPZ8 RN Biological and biophysical properties of the histone deacetylase inhibitor suberoylanilide hydroxamic acid are affected by the presence of short al... J Med Chem. 2010 Mar 11;53(5):1937-50. DM3DPZ8 RU https://pubmed.ncbi.nlm.nih.gov/20143840 DM4E8NJ DI DM4E8NJ DM4E8NJ DN N-hydroxy-N-[1-(4-isobutylphenyl)ethyl]urea DM4E8NJ MI TT2J34L DM4E8NJ MN Arachidonate 5-lipoxygenase (5-LOX) DM4E8NJ MT DTT DM4E8NJ MA Inhibitor DM4E8NJ RN Nonsteroidal anti-inflammatory drugs as scaffolds for the design of 5-lipoxygenase inhibitors. J Med Chem. 1997 Feb 28;40(5):819-24. DM4E8NJ RU https://pubmed.ncbi.nlm.nih.gov/9057869 DM4E8NJ DI DM4E8NJ DM4E8NJ DN N-hydroxy-N-[1-(4-isobutylphenyl)ethyl]urea DM4E8NJ MI TTSJ6Q4 DM4E8NJ MN LOX-5 messenger RNA (ALOX5 mRNA) DM4E8NJ MT DTT DM4E8NJ MA Inhibitor DM4E8NJ RN Nonsteroidal anti-inflammatory drugs as scaffolds for the design of 5-lipoxygenase inhibitors. J Med Chem. 1997 Feb 28;40(5):819-24. DM4E8NJ RU https://pubmed.ncbi.nlm.nih.gov/9057869 DMQ4ST2 DI DMQ4ST2 DMQ4ST2 DN N-Hydroxy-N-methyl-2,3,3-triphenyl-acrylamide DMQ4ST2 MI TT2J34L DMQ4ST2 MN Arachidonate 5-lipoxygenase (5-LOX) DMQ4ST2 MT DTT DMQ4ST2 MA Inhibitor DMQ4ST2 RN Hydroxamic acid inhibitors of 5-lipoxygenase: quantitative structure-activity relationships. J Med Chem. 1990 Mar;33(3):992-8. DMQ4ST2 RU https://pubmed.ncbi.nlm.nih.gov/2308149 DMNVD8I DI DMNVD8I DMNVD8I DN N-Hydroxy-N-methyl-2-naphthalen-2-yl-propionamide DMNVD8I MI TT2J34L DMNVD8I MN Arachidonate 5-lipoxygenase (5-LOX) DMNVD8I MT DTT DMNVD8I MA Inhibitor DMNVD8I RN Hydroxamic acid inhibitors of 5-lipoxygenase: quantitative structure-activity relationships. J Med Chem. 1990 Mar;33(3):992-8. DMNVD8I RU https://pubmed.ncbi.nlm.nih.gov/2308149 DMSRPI8 DI DMSRPI8 DMSRPI8 DN N-Hydroxy-N-methyl-3-naphthalen-1-yl-acrylamide DMSRPI8 MI TT2J34L DMSRPI8 MN Arachidonate 5-lipoxygenase (5-LOX) DMSRPI8 MT DTT DMSRPI8 MA Inhibitor DMSRPI8 RN Hydroxamic acid inhibitors of 5-lipoxygenase: quantitative structure-activity relationships. J Med Chem. 1990 Mar;33(3):992-8. DMSRPI8 RU https://pubmed.ncbi.nlm.nih.gov/2308149 DMANTW0 DI DMANTW0 DMANTW0 DN N-Hydroxy-N-methyl-3-naphthalen-2-yl-acrylamide DMANTW0 MI TT2J34L DMANTW0 MN Arachidonate 5-lipoxygenase (5-LOX) DMANTW0 MT DTT DMANTW0 MA Inhibitor DMANTW0 RN In vivo characterization of hydroxamic acid inhibitors of 5-lipoxygenase. J Med Chem. 1987 Nov;30(11):2121-6. DMANTW0 RU https://pubmed.ncbi.nlm.nih.gov/3669019 DMMYV34 DI DMMYV34 DMMYV34 DN N-Hydroxy-N-methyl-3-naphthalen-2-yl-propionamide DMMYV34 MI TT2J34L DMMYV34 MN Arachidonate 5-lipoxygenase (5-LOX) DMMYV34 MT DTT DMMYV34 MA Inhibitor DMMYV34 RN Hydroxamic acid inhibitors of 5-lipoxygenase: quantitative structure-activity relationships. J Med Chem. 1990 Mar;33(3):992-8. DMMYV34 RU https://pubmed.ncbi.nlm.nih.gov/2308149 DMAN57F DI DMAN57F DMAN57F DN N-Hydroxy-N-methyl-3-phenanthren-2-yl-acrylamide DMAN57F MI TT2J34L DMAN57F MN Arachidonate 5-lipoxygenase (5-LOX) DMAN57F MT DTT DMAN57F MA Inhibitor DMAN57F RN Hydroxamic acid inhibitors of 5-lipoxygenase: quantitative structure-activity relationships. J Med Chem. 1990 Mar;33(3):992-8. DMAN57F RU https://pubmed.ncbi.nlm.nih.gov/2308149 DMV8UCK DI DMV8UCK DMV8UCK DN N-Hydroxy-N-methyl-3-phenanthren-3-yl-acrylamide DMV8UCK MI TT2J34L DMV8UCK MN Arachidonate 5-lipoxygenase (5-LOX) DMV8UCK MT DTT DMV8UCK MA Inhibitor DMV8UCK RN Hydroxamic acid inhibitors of 5-lipoxygenase: quantitative structure-activity relationships. J Med Chem. 1990 Mar;33(3):992-8. DMV8UCK RU https://pubmed.ncbi.nlm.nih.gov/2308149 DMQBD27 DI DMQBD27 DMQBD27 DN N-Hydroxy-N-methyl-3-phenanthren-9-yl-acrylamide DMQBD27 MI TT2J34L DMQBD27 MN Arachidonate 5-lipoxygenase (5-LOX) DMQBD27 MT DTT DMQBD27 MA Inhibitor DMQBD27 RN Hydroxamic acid inhibitors of 5-lipoxygenase: quantitative structure-activity relationships. J Med Chem. 1990 Mar;33(3):992-8. DMQBD27 RU https://pubmed.ncbi.nlm.nih.gov/2308149 DMDQWOB DI DMDQWOB DMDQWOB DN N-Hydroxy-N-methyl-benzamide DMDQWOB MI TT2J34L DMDQWOB MN Arachidonate 5-lipoxygenase (5-LOX) DMDQWOB MT DTT DMDQWOB MA Inhibitor DMDQWOB RN Hydroxamic acid inhibitors of 5-lipoxygenase: quantitative structure-activity relationships. J Med Chem. 1990 Mar;33(3):992-8. DMDQWOB RU https://pubmed.ncbi.nlm.nih.gov/2308149 DMCIAJL DI DMCIAJL DMCIAJL DN N-hydroxy-nor-L-arginine DMCIAJL MI TTV1AG6 DMCIAJL MN Kidney-type arginase (ARG2) DMCIAJL MT DTT DMCIAJL MA Inhibitor DMCIAJL RN Arginase reciprocally regulates nitric oxide synthase activity and contributes to endothelial dysfunction in aging blood vessels. Circulation. 2003 Oct 21;108(16):2000-6. DMCIAJL RU https://pubmed.ncbi.nlm.nih.gov/14517171 DMTDBMU DI DMTDBMU DMTDBMU DN N-hydroxysulfamide DMTDBMU MI TTHQPL7 DMTDBMU MN Carbonic anhydrase I (CA-I) DMTDBMU MT DTT DMTDBMU MA Inhibitor DMTDBMU RN Carbonic anhydrase inhibitors: crystallographic and solution binding studies for the interaction of a boron-containing aromatic sulfamide with mamm... Bioorg Med Chem Lett. 2010 Jun 15;20(12):3601-5. DMTDBMU RU https://pubmed.ncbi.nlm.nih.gov/20472429 DMTDBMU DI DMTDBMU DMTDBMU DN N-hydroxysulfamide DMTDBMU MI TTANPDJ DMTDBMU MN Carbonic anhydrase II (CA-II) DMTDBMU MT DTT DMTDBMU MA Inhibitor DMTDBMU RN Carbonic anhydrase inhibitors: crystallographic and solution binding studies for the interaction of a boron-containing aromatic sulfamide with mamm... Bioorg Med Chem Lett. 2010 Jun 15;20(12):3601-5. DMTDBMU RU https://pubmed.ncbi.nlm.nih.gov/20472429 DMTDBMU DI DMTDBMU DMTDBMU DN N-hydroxysulfamide DMTDBMU MI TT2LVK8 DMTDBMU MN Carbonic anhydrase IX (CA-IX) DMTDBMU MT DTT DMTDBMU MA Inhibitor DMTDBMU RN Carbonic anhydrase inhibitors: crystallographic and solution binding studies for the interaction of a boron-containing aromatic sulfamide with mamm... Bioorg Med Chem Lett. 2010 Jun 15;20(12):3601-5. DMTDBMU RU https://pubmed.ncbi.nlm.nih.gov/20472429 DMTDBMU DI DMTDBMU DMTDBMU DN N-hydroxysulfamide DMTDBMU MI TTSYM0R DMTDBMU MN Carbonic anhydrase XII (CA-XII) DMTDBMU MT DTT DMTDBMU MA Inhibitor DMTDBMU RN Carbonic anhydrase inhibitors: crystallographic and solution binding studies for the interaction of a boron-containing aromatic sulfamide with mamm... Bioorg Med Chem Lett. 2010 Jun 15;20(12):3601-5. DMTDBMU RU https://pubmed.ncbi.nlm.nih.gov/20472429 DMJBC03 DI DMJBC03 DMJBC03 DN N-hydroxysulfonamides DMJBC03 MI TTHQPL7 DMJBC03 MN Carbonic anhydrase I (CA-I) DMJBC03 MT DTT DMJBC03 MA Inhibitor DMJBC03 RN Carbonic anhydrase inhibitors: inhibition of isozymes I, II and IV with N-hydroxysulfonamides--a novel class of intraocular pressure lowering agents. J Enzyme Inhib. 1998 Jul;13(4):267-84. DMJBC03 RU https://pubmed.ncbi.nlm.nih.gov/9795865 DMJBC03 DI DMJBC03 DMJBC03 DN N-hydroxysulfonamides DMJBC03 MI TTANPDJ DMJBC03 MN Carbonic anhydrase II (CA-II) DMJBC03 MT DTT DMJBC03 MA Inhibitor DMJBC03 RN Carbonic anhydrase inhibitors: inhibition of isozymes I, II and IV with N-hydroxysulfonamides--a novel class of intraocular pressure lowering agents. J Enzyme Inhib. 1998 Jul;13(4):267-84. DMJBC03 RU https://pubmed.ncbi.nlm.nih.gov/9795865 DMJBC03 DI DMJBC03 DMJBC03 DN N-hydroxysulfonamides DMJBC03 MI TTZHA0O DMJBC03 MN Carbonic anhydrase IV (CA-IV) DMJBC03 MT DTT DMJBC03 MA Inhibitor DMJBC03 RN Carbonic anhydrase inhibitors: inhibition of isozymes I, II and IV with N-hydroxysulfonamides--a novel class of intraocular pressure lowering agents. J Enzyme Inhib. 1998 Jul;13(4):267-84. DMJBC03 RU https://pubmed.ncbi.nlm.nih.gov/9795865 DMPK2JO DI DMPK2JO DMPK2JO DN NI-105 DMPK2JO MI TTS87KH DMPK2JO MN Microtubule-associated protein tau (MAPT) DMPK2JO MT DTT DMPK2JO MA Modulator DMPK2JO RN Microtubules (tau) as an emerging therapeutic target: NAP (davunetide). Curr Pharm Des. 2011;17(31):3413-7. DMPK2JO RU https://pubmed.ncbi.nlm.nih.gov/21902667 DM680XO DI DM680XO DM680XO DN NI-1201 DM680XO MI TT0E5SK DM680XO MN Interleukin 6 receptor (IL6R) DM680XO MT DTT DM680XO RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2310). DM680XO RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2310 DMG9OBA DI DMG9OBA DMG9OBA DN NI-1401 DMG9OBA MI TT69OHW DMG9OBA MN Interleukin 17 receptor (IL17R) DMG9OBA MT DTT DMG9OBA RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2294). DMG9OBA RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2294 DM52ITO DI DM52ITO DM52ITO DN NI-57 DM52ITO MI TTT46BN DM52ITO MN Bromodomain and PHD finger containing 1 (BRPF1) DM52ITO MT DTT DM52ITO MA Inhibitor DM52ITO RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2730). DM52ITO RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2730 DM52ITO DI DM52ITO DM52ITO DN NI-57 DM52ITO MI TT1CHFI DM52ITO MN Bromodomain and PHD finger containing 3 (BRPF3) DM52ITO MT DTT DM52ITO MA Inhibitor DM52ITO RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2731). DM52ITO RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2731 DM52ITO DI DM52ITO DM52ITO DN NI-57 DM52ITO MI TTT09OB DM52ITO MN Bromodomain-containing protein 1 (BRD1) DM52ITO MT DTT DM52ITO MA Inhibitor DM52ITO RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2724). DM52ITO RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2724 DMH6MVJ DI DMH6MVJ DMH6MVJ DN NIBR-0213 DMH6MVJ MI TT9JZCK DMH6MVJ MN Sphingosine-1-phosphate receptor 1 (S1PR1) DMH6MVJ MT DTT DMH6MVJ MA Antagonist DMH6MVJ RN A potent and selective S1P(1) antagonist with efficacy in experimental autoimmune encephalomyelitis. Chem Biol. 2012 Sep 21;19(9):1142-51. DMH6MVJ RU https://pubmed.ncbi.nlm.nih.gov/22999882 DMU0BMQ DI DMU0BMQ DMU0BMQ DN NIBR-785 DMU0BMQ MI TT9JZCK DMU0BMQ MN Sphingosine-1-phosphate receptor 1 (S1PR1) DMU0BMQ MT DTT DMU0BMQ MA Modulator DMU0BMQ RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 275). DMU0BMQ RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=275 DM4I6MD DI DM4I6MD DM4I6MD DN NICARBAZIN DM4I6MD MI TTDP1UC DM4I6MD MN Fatty acid amide hydrolase (FAAH) DM4I6MD MT DTT DM4I6MD MA Inhibitor DM4I6MD RN Mining biologically-active molecules for inhibitors of fatty acid amide hydrolase (FAAH): identification of phenmedipham and amperozide as FAAH inh... Bioorg Med Chem Lett. 2009 Dec 1;19(23):6793-6. DM4I6MD RU https://pubmed.ncbi.nlm.nih.gov/19850474 DMI12Y8 DI DMI12Y8 DMI12Y8 DN Nickel chloride DMI12Y8 MI TT729IR DMI12Y8 MN Voltage-gated calcium channel alpha Cav3.1 (CACNA1G) DMI12Y8 MT DTT DMI12Y8 MA Blocker DMI12Y8 RN T-type calcium channels facilitate insulin secretion by enhancing general excitability in the insulin-secreting beta-cell line, INS-1. Endocrinology. 1997 Sep;138(9):3735-40. DMI12Y8 RU https://pubmed.ncbi.nlm.nih.gov/9275059 DM0DFNJ DI DM0DFNJ DM0DFNJ DN Nicotinaldehyde O-4-butoxyphenylcarbamoyl oxime DM0DFNJ MI TTDP1UC DM0DFNJ MN Fatty acid amide hydrolase (FAAH) DM0DFNJ MT DTT DM0DFNJ MA Inhibitor DM0DFNJ RN Oxime carbamate--discovery of a series of novel FAAH inhibitors. Bioorg Med Chem Lett. 2010 Feb 1;20(3):1272-7. DM0DFNJ RU https://pubmed.ncbi.nlm.nih.gov/20036536 DM957CK DI DM957CK DM957CK DN Nicotinaldehyde O-4-ethoxyphenylcarbamoyl oxime DM957CK MI TTDP1UC DM957CK MN Fatty acid amide hydrolase (FAAH) DM957CK MT DTT DM957CK MA Inhibitor DM957CK RN Oxime carbamate--discovery of a series of novel FAAH inhibitors. Bioorg Med Chem Lett. 2010 Feb 1;20(3):1272-7. DM957CK RU https://pubmed.ncbi.nlm.nih.gov/20036536 DMC9WAL DI DMC9WAL DMC9WAL DN Nicotinaldehyde O-4-propoxyphenylcarbamoyl oxime DMC9WAL MI TTDP1UC DMC9WAL MN Fatty acid amide hydrolase (FAAH) DMC9WAL MT DTT DMC9WAL MA Inhibitor DMC9WAL RN Oxime carbamate--discovery of a series of novel FAAH inhibitors. Bioorg Med Chem Lett. 2010 Feb 1;20(3):1272-7. DMC9WAL RU https://pubmed.ncbi.nlm.nih.gov/20036536 DM9LRKB DI DM9LRKB DM9LRKB DN Nicotinamide-Adenine-Dinucleotide DM9LRKB MI TTE2KUJ DM9LRKB MN Adenosylhomocysteinase (AHCY) DM9LRKB MT DTT DM9LRKB MA Inhibitor DM9LRKB RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DM9LRKB RU https://pubmed.ncbi.nlm.nih.gov/17139284 DM9LRKB DI DM9LRKB DM9LRKB DN Nicotinamide-Adenine-Dinucleotide DM9LRKB MI TTHCF4J DM9LRKB MN Alpha-glucosidase (GLA) DM9LRKB MT DTT DM9LRKB MA Inhibitor DM9LRKB RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DM9LRKB RU https://pubmed.ncbi.nlm.nih.gov/17139284 DM9LRKB DI DM9LRKB DM9LRKB DN Nicotinamide-Adenine-Dinucleotide DM9LRKB MI TTPS7KA DM9LRKB MN Bacterial Dehydroquinate synthase (Bact aroB) DM9LRKB MT DTT DM9LRKB MA Inhibitor DM9LRKB RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DM9LRKB RU https://pubmed.ncbi.nlm.nih.gov/17139284 DM9LRKB DI DM9LRKB DM9LRKB DN Nicotinamide-Adenine-Dinucleotide DM9LRKB MI TTVTX4N DM9LRKB MN Bacterial Fatty acid synthetase I (Bact inhA) DM9LRKB MT DTT DM9LRKB MA Inhibitor DM9LRKB RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DM9LRKB RU https://pubmed.ncbi.nlm.nih.gov/17139284 DM9LRKB DI DM9LRKB DM9LRKB DN Nicotinamide-Adenine-Dinucleotide DM9LRKB MI TTNAW8S DM9LRKB MN Bacterial Flavohemoglobin (Bact hmp) DM9LRKB MT DTT DM9LRKB MA Inhibitor DM9LRKB RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DM9LRKB RU https://pubmed.ncbi.nlm.nih.gov/17139284 DM9LRKB DI DM9LRKB DM9LRKB DN Nicotinamide-Adenine-Dinucleotide DM9LRKB MI TT8WCXO DM9LRKB MN Bacterial NH(3)-dependent NAD(+) synthetase (Bact nadE) DM9LRKB MT DTT DM9LRKB MA Inhibitor DM9LRKB RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DM9LRKB RU https://pubmed.ncbi.nlm.nih.gov/17139284 DM9LRKB DI DM9LRKB DM9LRKB DN Nicotinamide-Adenine-Dinucleotide DM9LRKB MI TT1NFO3 DM9LRKB MN Bacterial Nicotinate-nucleotide adenylyltransferase (Bact nadD) DM9LRKB MT DTT DM9LRKB MA Inhibitor DM9LRKB RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DM9LRKB RU https://pubmed.ncbi.nlm.nih.gov/17139284 DM9LRKB DI DM9LRKB DM9LRKB DN Nicotinamide-Adenine-Dinucleotide DM9LRKB MI TTJBPN3 DM9LRKB MN Biliverdin reductase A (BLVRA) DM9LRKB MT DTT DM9LRKB MA Inhibitor DM9LRKB RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DM9LRKB RU https://pubmed.ncbi.nlm.nih.gov/17139284 DM9LRKB DI DM9LRKB DM9LRKB DN Nicotinamide-Adenine-Dinucleotide DM9LRKB MI TTBO2A9 DM9LRKB MN Deoxyhypusine synthase (DHPS) DM9LRKB MT DTT DM9LRKB MA Inhibitor DM9LRKB RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DM9LRKB RU https://pubmed.ncbi.nlm.nih.gov/17139284 DM9LRKB DI DM9LRKB DM9LRKB DN Nicotinamide-Adenine-Dinucleotide DM9LRKB MI TTJS7O4 DM9LRKB MN Entamoeba Alcohol dehydrogenase 2 (Entamo ADH2) DM9LRKB MT DTT DM9LRKB MA Inhibitor DM9LRKB RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DM9LRKB RU https://pubmed.ncbi.nlm.nih.gov/17139284 DM9LRKB DI DM9LRKB DM9LRKB DN Nicotinamide-Adenine-Dinucleotide DM9LRKB MI TTIWB6L DM9LRKB MN Estradiol 17 beta-dehydrogenase 1 (17-beta-HSD1) DM9LRKB MT DTT DM9LRKB MA Inhibitor DM9LRKB RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DM9LRKB RU https://pubmed.ncbi.nlm.nih.gov/17139284 DM9LRKB DI DM9LRKB DM9LRKB DN Nicotinamide-Adenine-Dinucleotide DM9LRKB MI TTL1WGS DM9LRKB MN Estradiol 17 beta-dehydrogenase 4 (HSD17B4) DM9LRKB MT DTT DM9LRKB MA Inhibitor DM9LRKB RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DM9LRKB RU https://pubmed.ncbi.nlm.nih.gov/17139284 DM9LRKB DI DM9LRKB DM9LRKB DN Nicotinamide-Adenine-Dinucleotide DM9LRKB MI TTEP6RV DM9LRKB MN Glutathione reductase (GR) DM9LRKB MT DTT DM9LRKB MA Inhibitor DM9LRKB RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DM9LRKB RU https://pubmed.ncbi.nlm.nih.gov/17139284 DM9LRKB DI DM9LRKB DM9LRKB DN Nicotinamide-Adenine-Dinucleotide DM9LRKB MI TTWUDYC DM9LRKB MN Haemophilus influenzae NadR protein (Hae-influ nadR) DM9LRKB MT DTT DM9LRKB MA Inhibitor DM9LRKB RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DM9LRKB RU https://pubmed.ncbi.nlm.nih.gov/17139284 DM9LRKB DI DM9LRKB DM9LRKB DN Nicotinamide-Adenine-Dinucleotide DM9LRKB MI TTPADOQ DM9LRKB MN HMG-CoA reductase (HMGCR) DM9LRKB MT DTT DM9LRKB MA Inhibitor DM9LRKB RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DM9LRKB RU https://pubmed.ncbi.nlm.nih.gov/17139284 DM9LRKB DI DM9LRKB DM9LRKB DN Nicotinamide-Adenine-Dinucleotide DM9LRKB MI TTTB4UP DM9LRKB MN Inosine-5'-monophosphate dehydrogenase 2 (IMPDH2) DM9LRKB MT DTT DM9LRKB MA Inhibitor DM9LRKB RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DM9LRKB RU https://pubmed.ncbi.nlm.nih.gov/17139284 DM9LRKB DI DM9LRKB DM9LRKB DN Nicotinamide-Adenine-Dinucleotide DM9LRKB MI TTXWASR DM9LRKB MN Intestinal maltase-glucoamylase (MGAM) DM9LRKB MT DTT DM9LRKB MA Inhibitor DM9LRKB RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DM9LRKB RU https://pubmed.ncbi.nlm.nih.gov/17139284 DM9LRKB DI DM9LRKB DM9LRKB DN Nicotinamide-Adenine-Dinucleotide DM9LRKB MI TTAZHU0 DM9LRKB MN L-lactate dehydrogenase (LDH) DM9LRKB MT DTT DM9LRKB MA Inhibitor DM9LRKB RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DM9LRKB RU https://pubmed.ncbi.nlm.nih.gov/17139284 DM9LRKB DI DM9LRKB DM9LRKB DN Nicotinamide-Adenine-Dinucleotide DM9LRKB MI TTFLN4T DM9LRKB MN Mitochondrial aldehyde dehydrogenase (ALDH2) DM9LRKB MT DTT DM9LRKB MA Inhibitor DM9LRKB RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DM9LRKB RU https://pubmed.ncbi.nlm.nih.gov/17139284 DM9LRKB DI DM9LRKB DM9LRKB DN Nicotinamide-Adenine-Dinucleotide DM9LRKB MI TTNX2CS DM9LRKB MN Plasmodium Enoyl-ACP reductase (Malaria fabI) DM9LRKB MT DTT DM9LRKB MA Inhibitor DM9LRKB RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DM9LRKB RU https://pubmed.ncbi.nlm.nih.gov/17139284 DM9LRKB DI DM9LRKB DM9LRKB DN Nicotinamide-Adenine-Dinucleotide DM9LRKB MI TTKVNRF DM9LRKB MN Pseudomonas Nicotinate-nucleotide adenylyltransferase (Pseudo nadD) DM9LRKB MT DTT DM9LRKB MA Inhibitor DM9LRKB RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DM9LRKB RU https://pubmed.ncbi.nlm.nih.gov/17139284 DM9LRKB DI DM9LRKB DM9LRKB DN Nicotinamide-Adenine-Dinucleotide DM9LRKB MI TTLSRBZ DM9LRKB MN Sorbitoldehydrogenase (SORD) DM9LRKB MT DTT DM9LRKB MA Inhibitor DM9LRKB RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DM9LRKB RU https://pubmed.ncbi.nlm.nih.gov/17139284 DM9LRKB DI DM9LRKB DM9LRKB DN Nicotinamide-Adenine-Dinucleotide DM9LRKB MI TTBKQL3 DM9LRKB MN Trypanosoma Dihydrolipoamide dehydrogenase (Trypano LPD) DM9LRKB MT DTT DM9LRKB MA Inhibitor DM9LRKB RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DM9LRKB RU https://pubmed.ncbi.nlm.nih.gov/17139284 DM9LRKB DI DM9LRKB DM9LRKB DN Nicotinamide-Adenine-Dinucleotide DM9LRKB MI TTGRHIB DM9LRKB MN UDP-glucose 4-epimerase (GALE) DM9LRKB MT DTT DM9LRKB MA Inhibitor DM9LRKB RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DM9LRKB RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMO7M2N DI DMO7M2N DMO7M2N DN Nicotinyl alcohol DMO7M2N MI DEJVYAZ DMO7M2N MN Cytochrome P450 2A6 (CYP2A6) DMO7M2N MT DME DMO7M2N MA Metabolism DMO7M2N RN Stability of the nicotine metabolite ratio in ad libitum and reducing smokers. Cancer Epidemiol Biomarkers Prev. 2008 Jun;17(6):1396-400. DMO7M2N RU https://www.ncbi.nlm.nih.gov/pubmed/?term=18559554 DMIK40C DI DMIK40C DMIK40C DN Nifeviroc DMIK40C MI TT2CEJG DMIK40C MN C-C chemokine receptor type 5 (CCR5) DMIK40C MT DTT DMIK40C MA Modulator DMIK40C RN Determination of nifeviroc, a novel CCR5 antagonist: application to a pharmacokinetic study. J Pharm Biomed Anal. 2011 Nov 1;56(3):637-40. DMIK40C RU https://pubmed.ncbi.nlm.nih.gov/21802236 DMDMG1O DI DMDMG1O DMDMG1O DN NIHP DMDMG1O MI TTMXGCW DMDMG1O MN Adrenergic receptor beta-3 (ADRB3) DMDMG1O MT DTT DMDMG1O MA Antagonist DMDMG1O RN LK 204-545, a highly selective beta1-adrenoceptor antagonist at human beta-adrenoceptors. Eur J Pharmacol. 1999 Feb 19;367(2-3):431-5. DMDMG1O RU https://pubmed.ncbi.nlm.nih.gov/10079020 DM0QJSO DI DM0QJSO DM0QJSO DN NILTUBACIN DM0QJSO MI TT5ZKDI DM0QJSO MN Histone deacetylase 6 (HDAC6) DM0QJSO MT DTT DM0QJSO MA Inhibitor DM0QJSO RN Chemical phylogenetics of histone deacetylases. Nat Chem Biol. 2010 Mar;6(3):238-243. DM0QJSO RU https://pubmed.ncbi.nlm.nih.gov/20139990 DM0QJSO DI DM0QJSO DM0QJSO DN NILTUBACIN DM0QJSO MI TTT6LFV DM0QJSO MN Histone deacetylase 8 (HDAC8) DM0QJSO MT DTT DM0QJSO MA Inhibitor DM0QJSO RN Chemical phylogenetics of histone deacetylases. Nat Chem Biol. 2010 Mar;6(3):238-243. DM0QJSO RU https://pubmed.ncbi.nlm.nih.gov/20139990 DM8OGMA DI DM8OGMA DM8OGMA DN Niludipine DM8OGMA MI DE4LYSA DM8OGMA MN Cytochrome P450 3A4 (CYP3A4) DM8OGMA MT DME DM8OGMA MA Metabolism DM8OGMA RN Integrated analysis on the physicochemical properties of dihydropyridine calcium channel blockers in grapefruit juice interactions. Curr Pharm Biotechnol. 2012 Jul;13(9):1705-17. DM8OGMA RU https://www.ncbi.nlm.nih.gov/pubmed/?term=22039822 DM8ZMB5 DI DM8ZMB5 DM8ZMB5 DN N-Indan-1-yl-2-(1H-indol-3-yl)-2-oxo-acetamide DM8ZMB5 MI TT1MPAY DM8ZMB5 MN GABA(A) receptor alpha-1 (GABRA1) DM8ZMB5 MT DTT DM8ZMB5 MA Inhibitor DM8ZMB5 RN Novel N-(arylalkyl)indol-3-ylglyoxylylamides targeted as ligands of the benzodiazepine receptor: synthesis, biological evaluation, and molecular mo... J Med Chem. 2001 Jul 5;44(14):2286-97. DM8ZMB5 RU https://pubmed.ncbi.nlm.nih.gov/11428922 DM8ZMB5 DI DM8ZMB5 DM8ZMB5 DN N-Indan-1-yl-2-(1H-indol-3-yl)-2-oxo-acetamide DM8ZMB5 MI TTZA1NY DM8ZMB5 MN GABA(A) receptor beta-2 (GABRB2) DM8ZMB5 MT DTT DM8ZMB5 MA Inhibitor DM8ZMB5 RN Novel N-(arylalkyl)indol-3-ylglyoxylylamides targeted as ligands of the benzodiazepine receptor: synthesis, biological evaluation, and molecular mo... J Med Chem. 2001 Jul 5;44(14):2286-97. DM8ZMB5 RU https://pubmed.ncbi.nlm.nih.gov/11428922 DM8ZMB5 DI DM8ZMB5 DM8ZMB5 DN N-Indan-1-yl-2-(1H-indol-3-yl)-2-oxo-acetamide DM8ZMB5 MI TT06RH5 DM8ZMB5 MN GABA(A) receptor gamma-2 (GABRG2) DM8ZMB5 MT DTT DM8ZMB5 MA Inhibitor DM8ZMB5 RN Novel N-(arylalkyl)indol-3-ylglyoxylylamides targeted as ligands of the benzodiazepine receptor: synthesis, biological evaluation, and molecular mo... J Med Chem. 2001 Jul 5;44(14):2286-97. DM8ZMB5 RU https://pubmed.ncbi.nlm.nih.gov/11428922 DM8ZMB5 DI DM8ZMB5 DM8ZMB5 DN N-Indan-1-yl-2-(1H-indol-3-yl)-2-oxo-acetamide DM8ZMB5 MI TTNJYV2 DM8ZMB5 MN Gamma-aminobutyric acid receptor (GAR) DM8ZMB5 MT DTT DM8ZMB5 MA Inhibitor DM8ZMB5 RN Novel N-(arylalkyl)indol-3-ylglyoxylylamides targeted as ligands of the benzodiazepine receptor: synthesis, biological evaluation, and molecular mo... J Med Chem. 2001 Jul 5;44(14):2286-97. DM8ZMB5 RU https://pubmed.ncbi.nlm.nih.gov/11428922 DMV53PH DI DMV53PH DMV53PH DN NIP-142 DMV53PH MI TTW0CMT DMV53PH MN Voltage-gated potassium channel Kv1.5 (KCNA5) DMV53PH MT DTT DMV53PH MA Blocker DMV53PH RN New antiarrhythmic agents for atrial fibrillation and atrial flutter. Expert Opin Emerg Drugs. 2005 May;10(2):311-22. DMV53PH RU https://pubmed.ncbi.nlm.nih.gov/15934869 DMPV450 DI DMPV450 DMPV450 DN NIPECOTIC ACID DMPV450 MI TTJFY5U DMPV450 MN Adenosine A3 receptor (ADORA3) DMPV450 MT DTT DMPV450 MA Inhibitor DMPV450 RN 2-n-Butyl-9-methyl-8-[1,2,3]triazol-2-yl-9H-purin-6-ylamine and analogues as A2A adenosine receptor antagonists. Design, synthesis, and pharmacolog... J Med Chem. 2005 Nov 3;48(22):6887-96. DMPV450 RU https://pubmed.ncbi.nlm.nih.gov/16250647 DMPV450 DI DMPV450 DMPV450 DN NIPECOTIC ACID DMPV450 MI TTT2LD9 DMPV450 MN GABA transaminase (ABAT) DMPV450 MT DTT DMPV450 MA Inhibitor DMPV450 RN Aminomethyl-1,2,4-benzothiadiazines as potential analogues of gamma-aminobutyric acid. Unexpected discovery of a taurine antagonist. J Med Chem. 1982 Feb;25(2):113-6. DMPV450 RU https://pubmed.ncbi.nlm.nih.gov/6276545 DMPV450 DI DMPV450 DMPV450 DN NIPECOTIC ACID DMPV450 MI TTPRKM0 DMPV450 MN GABA transporter GAT-1 (SLC6A1) DMPV450 MT DTT DMPV450 MA Inhibitor DMPV450 RN Epimeric cis-decahydroquinoline-5-carboxylic acids: effects on gamma-aminobutyric acid uptake and receptor binding in vitro. J Med Chem. 1981 Jul;24(7):788-94. DMPV450 RU https://pubmed.ncbi.nlm.nih.gov/6268788 DMPV450 DI DMPV450 DMPV450 DN NIPECOTIC ACID DMPV450 MI TT8RXO5 DMPV450 MN GABA transporter-3 (SLC6A11) DMPV450 MT DTT DMPV450 MA Inhibitor DMPV450 RN Epimeric cis-decahydroquinoline-5-carboxylic acids: effects on gamma-aminobutyric acid uptake and receptor binding in vitro. J Med Chem. 1981 Jul;24(7):788-94. DMPV450 RU https://pubmed.ncbi.nlm.nih.gov/6268788 DMPV450 DI DMPV450 DMPV450 DN NIPECOTIC ACID DMPV450 MI TTNJYV2 DMPV450 MN Gamma-aminobutyric acid receptor (GAR) DMPV450 MT DTT DMPV450 MA Inhibitor DMPV450 RN Orally active and potent inhibitors of gamma-aminobutyric acid uptake. J Med Chem. 1985 May;28(5):653-60. DMPV450 RU https://pubmed.ncbi.nlm.nih.gov/2985785 DM1R0WC DI DM1R0WC DM1R0WC DN NIS-62949 DM1R0WC MI TTZ97H5 DM1R0WC MN Phosphodiesterase 4A (PDE4A) DM1R0WC MT DTT DM1R0WC MA Inhibitor DM1R0WC RN Pharmacology of a novel, orally active PDE4 inhibitor. Pharmacology. 2009;83(5):275-86. DM1R0WC RU https://pubmed.ncbi.nlm.nih.gov/19321962 DMO4E9U DI DMO4E9U DMO4E9U DN N-isobutyl-2-oxo-2H-chromene-3-carboxamide DMO4E9U MI TTGP7BY DMO4E9U MN Monoamine oxidase type B (MAO-B) DMO4E9U MT DTT DMO4E9U MA Inhibitor DMO4E9U RN Synthesis, molecular modeling, and selective inhibitory activity against human monoamine oxidases of 3-carboxamido-7-substituted coumarins. J Med Chem. 2009 Apr 9;52(7):1935-42. DMO4E9U RU https://pubmed.ncbi.nlm.nih.gov/19267475 DM9Z6VP DI DM9Z6VP DM9Z6VP DN N-isobutylnorlitebamine DM9Z6VP MI TT1RS9F DM9Z6VP MN Acetylcholinesterase (AChE) DM9Z6VP MT DTT DM9Z6VP MA Inhibitor DM9Z6VP RN Litebamine N-homologues: preparation and anti-acetylcholinesterase activity. J Nat Prod. 1998 Jan;61(1):46-50. DM9Z6VP RU https://pubmed.ncbi.nlm.nih.gov/9461651 DMN1FIU DI DMN1FIU DMN1FIU DN N-isobutylnoroxymorphone DMN1FIU MI TTQW87Y DMN1FIU MN Opioid receptor kappa (OPRK1) DMN1FIU MT DTT DMN1FIU MA Inhibitor DMN1FIU RN Synthesis of N-isobutylnoroxymorphone from naltrexone by a selective cyclopropane ring opening reaction. Bioorg Med Chem Lett. 2008 Sep 15;18(18):4978-81. DMN1FIU RU https://pubmed.ncbi.nlm.nih.gov/18755589 DMN1FIU DI DMN1FIU DMN1FIU DN N-isobutylnoroxymorphone DMN1FIU MI TTKWM86 DMN1FIU MN Opioid receptor mu (MOP) DMN1FIU MT DTT DMN1FIU MA Inhibitor DMN1FIU RN Synthesis of N-isobutylnoroxymorphone from naltrexone by a selective cyclopropane ring opening reaction. Bioorg Med Chem Lett. 2008 Sep 15;18(18):4978-81. DMN1FIU RU https://pubmed.ncbi.nlm.nih.gov/18755589 DM53AS0 DI DM53AS0 DM53AS0 DN N-isoleucylthiazolidine DM53AS0 MI TTDIGC1 DM53AS0 MN Dipeptidyl peptidase 4 (DPP-4) DM53AS0 MT DTT DM53AS0 MA Inhibitor DM53AS0 RN 2-[3-[2-[(2S)-2-Cyano-1-pyrrolidinyl]-2-oxoethylamino]-3-methyl-1-oxobutyl]- 1,2,3,4-tetrahydroisoquinoline: a potent, selective, and orally bioava... J Med Chem. 2006 Jan 12;49(1):373-80. DM53AS0 RU https://pubmed.ncbi.nlm.nih.gov/16392822 DMC8L4J DI DMC8L4J DMC8L4J DN N-isopentyl-5,6-dip-tolylpyrazine-2-carboxamide DMC8L4J MI TT6OEDT DMC8L4J MN Cannabinoid receptor 1 (CB1) DMC8L4J MT DTT DMC8L4J MA Inhibitor DMC8L4J RN Discovery of pyrazine carboxamide CB1 antagonists: the introduction of a hydroxyl group improves the pharmaceutical properties and in vivo efficacy... Bioorg Med Chem Lett. 2007 Jul 15;17(14):3978-82. DMC8L4J RU https://pubmed.ncbi.nlm.nih.gov/17513109 DMFSW5M DI DMFSW5M DMFSW5M DN N-isopropyl estradiol-16-carboxamide DMFSW5M MI TTIWB6L DMFSW5M MN Estradiol 17 beta-dehydrogenase 1 (17-beta-HSD1) DMFSW5M MT DTT DMFSW5M MA Inhibitor DMFSW5M RN Modification of estrone at the 6, 16, and 17 positions: novel potent inhibitors of 17beta-hydroxysteroid dehydrogenase type 1. J Med Chem. 2006 Feb 23;49(4):1325-45. DMFSW5M RU https://pubmed.ncbi.nlm.nih.gov/16480268 DMHJMTI DI DMHJMTI DMHJMTI DN N-isopropyl estradiol-16-methyl carboxamide DMHJMTI MI TTIWB6L DMHJMTI MN Estradiol 17 beta-dehydrogenase 1 (17-beta-HSD1) DMHJMTI MT DTT DMHJMTI MA Inhibitor DMHJMTI RN Modification of estrone at the 6, 16, and 17 positions: novel potent inhibitors of 17beta-hydroxysteroid dehydrogenase type 1. J Med Chem. 2006 Feb 23;49(4):1325-45. DMHJMTI RU https://pubmed.ncbi.nlm.nih.gov/16480268 DMZGMQJ DI DMZGMQJ DMZGMQJ DN N-isopropyl estrone-16-methyl carboxamide DMZGMQJ MI TTIWB6L DMZGMQJ MN Estradiol 17 beta-dehydrogenase 1 (17-beta-HSD1) DMZGMQJ MT DTT DMZGMQJ MA Inhibitor DMZGMQJ RN Modification of estrone at the 6, 16, and 17 positions: novel potent inhibitors of 17beta-hydroxysteroid dehydrogenase type 1. J Med Chem. 2006 Feb 23;49(4):1325-45. DMZGMQJ RU https://pubmed.ncbi.nlm.nih.gov/16480268 DM14L7O DI DM14L7O DM14L7O DN N-Isopropyl-1'H-phenothiazine-1'-carboxamide DM14L7O MI TTEB0GD DM14L7O MN Cholinesterase (BCHE) DM14L7O MT DTT DM14L7O MA Inhibitor DM14L7O RN Differential binding of phenothiazine urea derivatives to wild-type human cholinesterases and butyrylcholinesterase mutants. Bioorg Med Chem. 2010 Mar 15;18(6):2232-2244. DM14L7O RU https://pubmed.ncbi.nlm.nih.gov/20181484 DMRPUCA DI DMRPUCA DMRPUCA DN N-isopropyl-5,6-dip-tolylpyrazine-2-carboxamide DMRPUCA MI TT6OEDT DMRPUCA MN Cannabinoid receptor 1 (CB1) DMRPUCA MT DTT DMRPUCA MA Inhibitor DMRPUCA RN Discovery of pyrazine carboxamide CB1 antagonists: the introduction of a hydroxyl group improves the pharmaceutical properties and in vivo efficacy... Bioorg Med Chem Lett. 2007 Jul 15;17(14):3978-82. DMRPUCA RU https://pubmed.ncbi.nlm.nih.gov/17513109 DMIVO8P DI DMIVO8P DMIVO8P DN N-Isopropyl-N'-Hydroxyguanidine DMIVO8P MI TTZUFI5 DMIVO8P MN Nitric-oxide synthase brain (NOS1) DMIVO8P MT DTT DMIVO8P MA Inhibitor DMIVO8P RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMIVO8P RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMG8NB0 DI DMG8NB0 DMG8NB0 DN N-isopropylnorlitebamine DMG8NB0 MI TT1RS9F DMG8NB0 MN Acetylcholinesterase (AChE) DMG8NB0 MT DTT DMG8NB0 MA Inhibitor DMG8NB0 RN Litebamine N-homologues: preparation and anti-acetylcholinesterase activity. J Nat Prod. 1998 Jan;61(1):46-50. DMG8NB0 RU https://pubmed.ncbi.nlm.nih.gov/9461651 DMDVO9T DI DMDVO9T DMDVO9T DN N-isopropylnorlitebamineN-methoiodide DMDVO9T MI TT1RS9F DMDVO9T MN Acetylcholinesterase (AChE) DMDVO9T MT DTT DMDVO9T MA Inhibitor DMDVO9T RN Litebamine N-homologues: preparation and anti-acetylcholinesterase activity. J Nat Prod. 1998 Jan;61(1):46-50. DMDVO9T RU https://pubmed.ncbi.nlm.nih.gov/9461651 DMZBNH0 DI DMZBNH0 DMZBNH0 DN Nisoxetine DMZBNH0 MI TTVBI8W DMZBNH0 MN Dopamine transporter (DAT) DMZBNH0 MT DTT DMZBNH0 MA Inhibitor DMZBNH0 RN Discovery of a potent, selective, and less flexible selective norepinephrine reuptake inhibitor (sNRI). Bioorg Med Chem Lett. 2008 Jul 15;18(14):4224-7. DMZBNH0 RU https://pubmed.ncbi.nlm.nih.gov/18550369 DMZBNH0 DI DMZBNH0 DMZBNH0 DN Nisoxetine DMZBNH0 MI TTAWNKZ DMZBNH0 MN Norepinephrine transporter (NET) DMZBNH0 MT DTT DMZBNH0 MA Inhibitor DMZBNH0 RN Synthesis and activity of 1-(3-amino-1-phenylpropyl)indolin-2-ones: a new class of selective norepinephrine reuptake inhibitors. Bioorg Med Chem Lett. 2008 Sep 15;18(18):4929-31. DMZBNH0 RU https://pubmed.ncbi.nlm.nih.gov/18771916 DMZBNH0 DI DMZBNH0 DMZBNH0 DN Nisoxetine DMZBNH0 MI TT3ROYC DMZBNH0 MN Serotonin transporter (SERT) DMZBNH0 MT DTT DMZBNH0 MA Inhibitor DMZBNH0 RN 1-Naphthyl and 4-indolyl arylalkylamines as selective monoamine reuptake inhibitors. Bioorg Med Chem Lett. 2009 Jan 1;19(1):58-61. DMZBNH0 RU https://pubmed.ncbi.nlm.nih.gov/19038547 DMY59KQ DI DMY59KQ DMY59KQ DN Nitracrine DMY59KQ MI TTUTN1I DMY59KQ MN Human Deoxyribonucleic acid (hDNA) DMY59KQ MT DTT DMY59KQ MA Breaker DMY59KQ RN Crosslinking of cellular DNA by nitracrine and furocoumarin derivatives. Neoplasma. 1999;46(1):50-3. DMY59KQ RU https://pubmed.ncbi.nlm.nih.gov/10355534 DMVDM0Q DI DMVDM0Q DMVDM0Q DN NITRAQUAZONE DMVDM0Q MI TTZ97H5 DMVDM0Q MN Phosphodiesterase 4A (PDE4A) DMVDM0Q MT DTT DMVDM0Q MA Inhibitor DMVDM0Q RN Synthesis and biological evaluation of 2,5-dihydropyrazol. Bioorg Med Chem Lett. 2000 Dec 4;10(23):2661-4. DMVDM0Q RU https://pubmed.ncbi.nlm.nih.gov/11128646 DMVDM0Q DI DMVDM0Q DMVDM0Q DN NITRAQUAZONE DMVDM0Q MI TTVIAT9 DMVDM0Q MN Phosphodiesterase 4B (PDE4B) DMVDM0Q MT DTT DMVDM0Q MA Inhibitor DMVDM0Q RN Synthesis and biological evaluation of 2,5-dihydropyrazol. Bioorg Med Chem Lett. 2000 Dec 4;10(23):2661-4. DMVDM0Q RU https://pubmed.ncbi.nlm.nih.gov/11128646 DMVFB93 DI DMVFB93 DMVFB93 DN Nitrate DMVFB93 MI DTOTME4 DMVFB93 MN Anion exchange transporter (SLC26A7) DMVFB93 MT DTP DMVFB93 MA Substrate DMVFB93 RN The Transporter Classification Database (TCDB): recent advances. Nucleic Acids Res. 2016 Jan 4;44(D1):D372-9. (ID: 2.A.53.2.6) DMVFB93 RU http://www.tcdb.org/search/result.php?tc=2.A.53.2.6 DMVFB93 DI DMVFB93 DMVFB93 DN Nitrate DMVFB93 MI TTHQPL7 DMVFB93 MN Carbonic anhydrase I (CA-I) DMVFB93 MT DTT DMVFB93 MA Inhibitor DMVFB93 RN Carbonic anhydrase inhibitors. Inhibition of the newly isolated murine isozyme XIII with anions. Bioorg Med Chem Lett. 2004 Nov 1;14(21):5435-9. DMVFB93 RU https://pubmed.ncbi.nlm.nih.gov/15454240 DMVFB93 DI DMVFB93 DMVFB93 DN Nitrate DMVFB93 MI TTANPDJ DMVFB93 MN Carbonic anhydrase II (CA-II) DMVFB93 MT DTT DMVFB93 MA Inhibitor DMVFB93 RN Carbonic anhydrase inhibitors. Inhibition of the newly isolated murine isozyme XIII with anions. Bioorg Med Chem Lett. 2004 Nov 1;14(21):5435-9. DMVFB93 RU https://pubmed.ncbi.nlm.nih.gov/15454240 DMVFB93 DI DMVFB93 DMVFB93 DN Nitrate DMVFB93 MI DTZAH46 DMVFB93 MN Sodium/iodide cotransporter (SLC5A5) DMVFB93 MT DTP DMVFB93 MA Substrate DMVFB93 RN The Transporter Classification Database (TCDB): recent advances. Nucleic Acids Res. 2016 Jan 4;44(D1):D372-9. (ID: 2.A.21.5.1) DMVFB93 RU http://www.tcdb.org/search/result.php?tc=2.A.21.5.1 DMVFB93 DI DMVFB93 DMVFB93 DN Nitrate DMVFB93 MI DTWLACT DMVFB93 MN Vesicular H(+)/Aspartate-glutamate cotransporter (SLC17A5) DMVFB93 MT DTP DMVFB93 MA Substrate DMVFB93 RN Sialin (SLC17A5) functions as a nitrate transporter in the plasma membrane. Proc Natl Acad Sci U S A. 2012 Aug 14;109(33):13434-9. DMVFB93 RU http://www.ncbi.nlm.nih.gov/pubmed/22778404 DMIOQFU DI DMIOQFU DMIOQFU DN Nitrilotriacetic Acid DMIOQFU MI TTSZDQU DMIOQFU MN Lactotransferrin (LTF) DMIOQFU MT DTT DMIOQFU MA Inhibitor DMIOQFU RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMIOQFU RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMR5XT3 DI DMR5XT3 DMR5XT3 DN Nitrite DMR5XT3 MI DE1VDSF DMR5XT3 MN MOSC domain-containing protein 1 (MARC1) DMR5XT3 MT DME DMR5XT3 MA Metabolism DMR5XT3 RN Nitrite reductase and nitric-oxide synthase activity of the mitochondrial molybdopterin enzymes mARC1 and mARC2. J Biol Chem. 2014 Apr 11;289(15):10345-58. DMR5XT3 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=24500710 DMR5XT3 DI DMR5XT3 DMR5XT3 DN Nitrite DMR5XT3 MI DE6QH2D DMR5XT3 MN MOSC domain-containing protein 2 (MARC2) DMR5XT3 MT DME DMR5XT3 MA Metabolism DMR5XT3 RN Nitrite reductase and nitric-oxide synthase activity of the mitochondrial molybdopterin enzymes mARC1 and mARC2. J Biol Chem. 2014 Apr 11;289(15):10345-58. DMR5XT3 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=24500710 DM7T80N DI DM7T80N DM7T80N DN Nitroarginine DM7T80N MI TTZUFI5 DM7T80N MN Nitric-oxide synthase brain (NOS1) DM7T80N MT DTT DM7T80N MA Inhibitor DM7T80N RN Crystal structure of nitric oxide synthase bound to nitro indazole reveals a novel inactivation mechanism. Biochemistry. 2001 Nov 13;40(45):13448-55. DM7T80N RU https://pubmed.ncbi.nlm.nih.gov/11695891 DM7T80N DI DM7T80N DM7T80N DN Nitroarginine DM7T80N MI TTCM4B3 DM7T80N MN Nitric-oxide synthase endothelial (NOS3) DM7T80N MT DTT DM7T80N MA Inhibitor DM7T80N RN Crystal structure of nitric oxide synthase bound to nitro indazole reveals a novel inactivation mechanism. Biochemistry. 2001 Nov 13;40(45):13448-55. DM7T80N RU https://pubmed.ncbi.nlm.nih.gov/11695891 DM4UHB5 DI DM4UHB5 DM4UHB5 DN Nitrobenzaldehyde DM4UHB5 MI DED2FW3 DM4UHB5 MN Aldo-keto reductase 1A1 (AKR1A1) DM4UHB5 MT DME DM4UHB5 MA Metabolism DM4UHB5 RN The C-terminal loop of aldehyde reductase determines the substrate and inhibitor specificity. Biochemistry. 1996 Nov 12;35(45):14276-80. DM4UHB5 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=8916913 DM4UHB5 DI DM4UHB5 DM4UHB5 DN Nitrobenzaldehyde DM4UHB5 MI DER0XCH DM4UHB5 MN Farnesol dehydrogenase (AKR1B15) DM4UHB5 MT DME DM4UHB5 MA Metabolism DM4UHB5 RN Functional expression of novel human and murine AKR1B genes. Chem Biol Interact. 2011 May 30;191(1-3):177-84. DM4UHB5 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=21276782 DM4UHB5 DI DM4UHB5 DM4UHB5 DN Nitrobenzaldehyde DM4UHB5 MI DEIVKZ8 DM4UHB5 MN NADPH-dependent carbonyl reductase 3 (CBR3) DM4UHB5 MT DME DM4UHB5 MA Metabolism DM4UHB5 RN Different functions between human monomeric carbonyl reductase 3 and carbonyl reductase 1. Mol Cell Biochem. 2008 Aug;315(1-2):113-21. DM4UHB5 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=18493841 DMN6L70 DI DMN6L70 DMN6L70 DN Nitrobenzanthrone DMN6L70 MI DENP5RY DMN6L70 MN Quinone reductase 1 (NQO1) DMN6L70 MT DME DMN6L70 MA Metabolism DMN6L70 RN Dose-dependent response to 3-nitrobenzanthrone exposure in human urothelial cancer cells. Chem Res Toxicol. 2017 Oct 16;30(10):1855-1864. DMN6L70 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=28922594 DM6FVHC DI DM6FVHC DM6FVHC DN Nitrobenzoate DM6FVHC MI DE0K82S DM6FVHC MN Nitroreductase (NTR) DM6FVHC MT DME DM6FVHC MA Metabolism DM6FVHC RN nan DM6FVHC RU nan DM6FVHC DI DM6FVHC DM6FVHC DN Nitrobenzoate DM6FVHC MI DED6V8P DM6FVHC MN Oxygen-insensitive NADPH nitroreductase A (nfsA) DM6FVHC MT DME DM6FVHC MA Metabolism DM6FVHC RN nan DM6FVHC RU nan DM254EW DI DM254EW DM254EW DN Nitrobenzodiazepine DM254EW MI DE3N2FM DM254EW MN NADPH-cytochrome P450 reductase (CPR) DM254EW MT DME DM254EW MA Metabolism DM254EW RN Flavin-containing reductase: new perspective on the detoxification of nitrobenzodiazepine. Expert Opin Drug Metab Toxicol. 2010 Aug;6(8):967-81. DM254EW RU https://pubmed.ncbi.nlm.nih.gov/20504108 DM254EW DI DM254EW DM254EW DN Nitrobenzodiazepine DM254EW MI DE0QLUZ DM254EW MN Oxygen-insensitive NADPH nitroreductase B (nfsB) DM254EW MT DME DM254EW MA Metabolism DM254EW RN Structure-based development of bacterial nitroreductase against nitrobenzodiazepine-induced hypnosis. Biochem Pharmacol. 2012 Jun 15;83(12):1690-9. DM254EW RU https://pubmed.ncbi.nlm.nih.gov/22445794 DM7F3RY DI DM7F3RY DM7F3RY DN Nitrobenzylthioinosine DM7F3RY MI TTLXAKE DM7F3RY MN Solute carrier family 29 member 1 (SLC29A1) DM7F3RY MT DTT DM7F3RY MA Inhibitor DM7F3RY RN The role of human nucleoside transporters in uptake of 3'-deoxy-3'-fluorothymidine. Mol Pharmacol. 2008 Nov;74(5):1372-80. DM7F3RY RU https://pubmed.ncbi.nlm.nih.gov/18669604 DMGUNIL DI DMGUNIL DMGUNIL DN Nitrocatechol sulfate DMGUNIL MI DEEGA13 DMGUNIL MN Telethon sulfatase (ARSK) DMGUNIL MT DME DMGUNIL MA Metabolism DMGUNIL RN Arylsulfatase K, a novel lysosomal sulfatase. J Biol Chem. 2013 Oct 18;288(42):30019-28. DMGUNIL RU https://www.ncbi.nlm.nih.gov/pubmed/?term=23986440 DM7M5VY DI DM7M5VY DM7M5VY DN NITROCEFIN DM7M5VY MI TTLP6GN DM7M5VY MN Bacterial DD-carboxypeptidase (Bact vanYB) DM7M5VY MT DTT DM7M5VY MA Inhibitor DM7M5VY RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DM7M5VY RU https://pubmed.ncbi.nlm.nih.gov/10592235 DMWCV48 DI DMWCV48 DMWCV48 DN Nitroflurbiprofen DMWCV48 MI TT8NGED DMWCV48 MN Prostaglandin G/H synthase 1 (COX-1) DMWCV48 MT DTT DMWCV48 MA Modulator DMWCV48 RN The cyclooxygenase inhibitor flurbiprofen reduces radiation-induced angiogenic growth factor secretion of squamous cell carcinoma cell lines. Ann N Y Acad Sci. 2004 Dec;1030:37-42. DMWCV48 RU https://www.ncbi.nlm.nih.gov/pubmed/15659778 DMWCV48 DI DMWCV48 DMWCV48 DN Nitroflurbiprofen DMWCV48 MI TTVKILB DMWCV48 MN Prostaglandin G/H synthase 2 (COX-2) DMWCV48 MT DTT DMWCV48 MA Modulator DMWCV48 RN The cyclooxygenase inhibitor flurbiprofen reduces radiation-induced angiogenic growth factor secretion of squamous cell carcinoma cell lines. Ann N Y Acad Sci. 2004 Dec;1030:37-42. DMWCV48 RU https://www.ncbi.nlm.nih.gov/pubmed/15659778 DMMY2S5 DI DMMY2S5 DMMY2S5 DN Nitroimidazole DMMY2S5 MI DEX5D46 DMMY2S5 MN Oxygen-insensitive NADPH nitroreductase A (nfsA) DMMY2S5 MT DME DMMY2S5 MA Metabolism DMMY2S5 RN Delamanid is not metabolized by Salmonella or human nitroreductases: a possible mechanism for the lack of mutagenicity. Regul Toxicol Pharmacol. 2017 Mar;84:1-8. DMMY2S5 RU https://pubmed.ncbi.nlm.nih.gov/27988333 DMMY2S5 DI DMMY2S5 DMMY2S5 DN Nitroimidazole DMMY2S5 MI DEOWDK1 DMMY2S5 MN Oxygen-insensitive NADPH nitroreductase B (nfsB) DMMY2S5 MT DME DMMY2S5 MA Metabolism DMMY2S5 RN Delamanid is not metabolized by Salmonella or human nitroreductases: a possible mechanism for the lack of mutagenicity. Regul Toxicol Pharmacol. 2017 Mar;84:1-8. DMMY2S5 RU https://pubmed.ncbi.nlm.nih.gov/27988333 DMMY2S5 DI DMMY2S5 DMMY2S5 DN Nitroimidazole DMMY2S5 MI DEKVGPX DMMY2S5 MN Retro-nitroreductase (rNR) DMMY2S5 MT DME DMMY2S5 MA Metabolism DMMY2S5 RN Retro-nitroreductase, a putative evolutionary precursor to Enterobacter cloacae strain 96-3 nitroreductase. Antioxid Redox Signal. 2001 Oct;3(5):747-55. DMMY2S5 RU https://pubmed.ncbi.nlm.nih.gov/11761325 DMHSD8A DI DMHSD8A DMHSD8A DN Nitrophenyl acetate DMHSD8A MI DE1Z0MO DMHSD8A MN Carbonic anhydrase II (CA2) DMHSD8A MT DME DMHSD8A MA Metabolism DMHSD8A RN Inhibition profiling of human carbonic anhydrase II by high-throughput screening of structurally diverse, biologically active compounds. J Biomol Screen. 2006 Oct;11(7):782-91. DMHSD8A RU https://www.ncbi.nlm.nih.gov/pubmed/?term=16858005 DMHSD8A DI DMHSD8A DMHSD8A DN Nitrophenyl acetate DMHSD8A MI DEB30C5 DMHSD8A MN Carboxylesterase 1 (CES1) DMHSD8A MT DME DMHSD8A MA Metabolism DMHSD8A RN Characterization of pyrethroid hydrolysis by the human liver carboxylesterases hCE-1 and hCE-2. Arch Biochem Biophys. 2006 Jan 1;445(1):115-23. DMHSD8A RU https://www.ncbi.nlm.nih.gov/pubmed/?term=16359636 DMZ9WI4 DI DMZ9WI4 DMZ9WI4 DN Nitrosoglutathione DMZ9WI4 MI DEAH3PE DMZ9WI4 MN S-(hydroxymethyl)glutathione dehydrogenase (adh) DMZ9WI4 MT DME DMZ9WI4 MA Metabolism DMZ9WI4 RN Nitrosative stress response in Vibrio cholerae: role of S-nitrosoglutathione reductase. Appl Biochem Biotechnol. 2017 Jul;182(3):871-884. DMZ9WI4 RU https://pubmed.ncbi.nlm.nih.gov/28000045 DMY729C DI DMY729C DMY729C DN NK314 DMY729C MI TTCGY2K DMY729C MN DNA topoisomerase II alpha (TOP2A) DMY729C MT DTT DMY729C MA Inhibitor DMY729C RN NK314, a topoisomerase II inhibitor that specifically targets the alpha isoform. J Biol Chem. 2008 Aug 29;283(35):23711-20. DMY729C RU https://pubmed.ncbi.nlm.nih.gov/18596031 DM9WC1T DI DM9WC1T DM9WC1T DN NK3201 DM9WC1T MI TT8VUE0 DM9WC1T MN Chymase (CYM) DM9WC1T MT DTT DM9WC1T MA Inhibitor DM9WC1T RN Impact of chymase inhibitor on cardiac function and survival after myocardial infarction. Cardiovasc Res. 2003 Nov 1;60(2):413-20. DM9WC1T RU https://pubmed.ncbi.nlm.nih.gov/14613871 DMSB2YG DI DMSB2YG DMSB2YG DN NKY80 DMSB2YG MI TTN64VU DMSB2YG MN Adenylate cyclase type 5 (AC5) DMSB2YG MT DTT DMSB2YG MA Inhibitor DMSB2YG RN Type-specific regulation of adenylyl cyclase. Selective pharmacological stimulation and inhibition of adenylyl cyclase isoforms. J Biol Chem. 2001 Dec 21;276(51):47785-93. DMSB2YG RU https://pubmed.ncbi.nlm.nih.gov/11602596 DM0FA6B DI DM0FA6B DM0FA6B DN Nle-Pro-Glu DM0FA6B MI TTLD29N DM0FA6B MN Glutamate receptor ionotropic NMDA 1 (NMDAR1) DM0FA6B MT DTT DM0FA6B MA Inhibitor DM0FA6B RN New Gly-Pro-Glu (GPE) analogues: expedite solid-phase synthesis and biological activity. Bioorg Med Chem Lett. 2006 Mar 1;16(5):1392-6. DM0FA6B RU https://pubmed.ncbi.nlm.nih.gov/16321525 DM0FA6B DI DM0FA6B DM0FA6B DN Nle-Pro-Glu DM0FA6B MI TTKJEMQ DM0FA6B MN Glutamate receptor ionotropic NMDA 2A (NMDAR2A) DM0FA6B MT DTT DM0FA6B MA Inhibitor DM0FA6B RN New Gly-Pro-Glu (GPE) analogues: expedite solid-phase synthesis and biological activity. Bioorg Med Chem Lett. 2006 Mar 1;16(5):1392-6. DM0FA6B RU https://pubmed.ncbi.nlm.nih.gov/16321525 DM0FA6B DI DM0FA6B DM0FA6B DN Nle-Pro-Glu DM0FA6B MI TTN9D8E DM0FA6B MN Glutamate receptor ionotropic NMDA 2B (NMDAR2B) DM0FA6B MT DTT DM0FA6B MA Inhibitor DM0FA6B RN New Gly-Pro-Glu (GPE) analogues: expedite solid-phase synthesis and biological activity. Bioorg Med Chem Lett. 2006 Mar 1;16(5):1392-6. DM0FA6B RU https://pubmed.ncbi.nlm.nih.gov/16321525 DM6RA20 DI DM6RA20 DM6RA20 DN NM-2014 DM6RA20 MI TTG043C DM6RA20 MN Tumor necrosis factor receptor type I (TNF-R1) DM6RA20 MT DTT DM6RA20 MA Modulator DM6RA20 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1870). DM6RA20 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1870 DMC89HI DI DMC89HI DMC89HI DN NM-9308 DMC89HI MI TTA0P7K DMC89HI MN Complement factor B (CFB) DMC89HI MT DTT DMC89HI RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2339). DMC89HI RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2339 DMKMBSJ DI DMKMBSJ DMKMBSJ DN NM-9405 DMKMBSJ MI TTG043C DMKMBSJ MN Tumor necrosis factor receptor type I (TNF-R1) DMKMBSJ MT DTT DMKMBSJ RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1870). DMKMBSJ RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1870 DM5Q9FG DI DM5Q9FG DM5Q9FG DN NMB-T-BMX-OS01 DM5Q9FG MI TTT6LFV DM5Q9FG MN Histone deacetylase 8 (HDAC8) DM5Q9FG MT DTT DM5Q9FG MA Inhibitor DM5Q9FG RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2619). DM5Q9FG RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2619 DMM731A DI DMM731A DMM731A DN N-Me-aminopyrimidinone 9 DMM731A MI TT4G2JS DMM731A MN Voltage-gated sodium channel alpha Nav1.7 (SCN9A) DMM731A MT DTT DMM731A MA Inhibitor (gating inhibitor) DMM731A RN Discovery and optimization of aminopyrimidinones as potent and state-dependent Nav1.7 antagonists. Bioorg Med Chem Lett. 2012 Jan 15;22(2):1055-60. DMM731A RU https://pubmed.ncbi.nlm.nih.gov/22209205 DMI065U DI DMI065U DMI065U DN N-mesityl-4,6-dimethyl-3-tosylpyridin-2-amine DMI065U MI TT7EFHR DMI065U MN Corticotropin-releasing factor receptor 1 (CRHR1) DMI065U MT DTT DMI065U MA Inhibitor DMI065U RN Synthesis and evaluation of 2-anilino-3-phenylsulfonyl-6-methylpyridines as corticotropin-releasing factor1 receptor ligands. Bioorg Med Chem Lett. 2006 Feb 15;16(4):934-7. DMI065U RU https://pubmed.ncbi.nlm.nih.gov/16297619 DMEUI8C DI DMEUI8C DMEUI8C DN N-mesityl-6-methyl-3-tosylpyridin-2-amine DMEUI8C MI TT7EFHR DMEUI8C MN Corticotropin-releasing factor receptor 1 (CRHR1) DMEUI8C MT DTT DMEUI8C MA Inhibitor DMEUI8C RN Synthesis and evaluation of 2-anilino-3-phenylsulfonyl-6-methylpyridines as corticotropin-releasing factor1 receptor ligands. Bioorg Med Chem Lett. 2006 Feb 15;16(4):934-7. DMEUI8C RU https://pubmed.ncbi.nlm.nih.gov/16297619 DMI9QRO DI DMI9QRO DMI9QRO DN N-methoxyethyl estrone-16-methyl carboxamide DMI9QRO MI TTIWB6L DMI9QRO MN Estradiol 17 beta-dehydrogenase 1 (17-beta-HSD1) DMI9QRO MT DTT DMI9QRO MA Inhibitor DMI9QRO RN Modification of estrone at the 6, 16, and 17 positions: novel potent inhibitors of 17beta-hydroxysteroid dehydrogenase type 1. J Med Chem. 2006 Feb 23;49(4):1325-45. DMI9QRO RU https://pubmed.ncbi.nlm.nih.gov/16480268 DMMB3PG DI DMMB3PG DMMB3PG DN N-methoxyquinuclidine-3-carboximidoyl chloride DMMB3PG MI TTZ9SOR DMMB3PG MN Muscarinic acetylcholine receptor M1 (CHRM1) DMMB3PG MT DTT DMMB3PG MA Inhibitor DMMB3PG RN A novel and selective class of azabicyclic muscarinic agonists incorporating an N-methoxy imidoyl halide or nitrile functionality, Bioorg. Med. Chem. Lett. 2(8):791-796 (1992). DMMB3PG RU http://www.sciencedirect.com/science/article/pii/S0960894X00805338 DMMB3PG DI DMMB3PG DMMB3PG DN N-methoxyquinuclidine-3-carboximidoyl chloride DMMB3PG MI TTYEG6Q DMMB3PG MN Muscarinic acetylcholine receptor M2 (CHRM2) DMMB3PG MT DTT DMMB3PG MA Inhibitor DMMB3PG RN A novel and selective class of azabicyclic muscarinic agonists incorporating an N-methoxy imidoyl halide or nitrile functionality, Bioorg. Med. Chem. Lett. 2(8):791-796 (1992). DMMB3PG RU http://www.sciencedirect.com/science/article/pii/S0960894X00805338 DMMB3PG DI DMMB3PG DMMB3PG DN N-methoxyquinuclidine-3-carboximidoyl chloride DMMB3PG MI TTQ13Z5 DMMB3PG MN Muscarinic acetylcholine receptor M3 (CHRM3) DMMB3PG MT DTT DMMB3PG MA Inhibitor DMMB3PG RN A novel and selective class of azabicyclic muscarinic agonists incorporating an N-methoxy imidoyl halide or nitrile functionality, Bioorg. Med. Chem. Lett. 2(8):791-796 (1992). DMMB3PG RU http://www.sciencedirect.com/science/article/pii/S0960894X00805338 DMMB3PG DI DMMB3PG DMMB3PG DN N-methoxyquinuclidine-3-carboximidoyl chloride DMMB3PG MI TTQ3JTF DMMB3PG MN Muscarinic acetylcholine receptor M4 (CHRM4) DMMB3PG MT DTT DMMB3PG MA Inhibitor DMMB3PG RN A novel and selective class of azabicyclic muscarinic agonists incorporating an N-methoxy imidoyl halide or nitrile functionality, Bioorg. Med. Chem. Lett. 2(8):791-796 (1992). DMMB3PG RU http://www.sciencedirect.com/science/article/pii/S0960894X00805338 DMMB3PG DI DMMB3PG DMMB3PG DN N-methoxyquinuclidine-3-carboximidoyl chloride DMMB3PG MI TTH18TF DMMB3PG MN Muscarinic acetylcholine receptor M5 (CHRM5) DMMB3PG MT DTT DMMB3PG MA Inhibitor DMMB3PG RN A novel and selective class of azabicyclic muscarinic agonists incorporating an N-methoxy imidoyl halide or nitrile functionality, Bioorg. Med. Chem. Lett. 2(8):791-796 (1992). DMMB3PG RU http://www.sciencedirect.com/science/article/pii/S0960894X00805338 DMF8IA6 DI DMF8IA6 DMF8IA6 DN N-methoxyquinuclidine-3-carboximidoyl fluoride DMF8IA6 MI TTZ9SOR DMF8IA6 MN Muscarinic acetylcholine receptor M1 (CHRM1) DMF8IA6 MT DTT DMF8IA6 MA Inhibitor DMF8IA6 RN A novel and selective class of azabicyclic muscarinic agonists incorporating an N-methoxy imidoyl halide or nitrile functionality, Bioorg. Med. Chem. Lett. 2(8):791-796 (1992). DMF8IA6 RU http://www.sciencedirect.com/science/article/pii/S0960894X00805338 DMF8IA6 DI DMF8IA6 DMF8IA6 DN N-methoxyquinuclidine-3-carboximidoyl fluoride DMF8IA6 MI TTYEG6Q DMF8IA6 MN Muscarinic acetylcholine receptor M2 (CHRM2) DMF8IA6 MT DTT DMF8IA6 MA Inhibitor DMF8IA6 RN A novel and selective class of azabicyclic muscarinic agonists incorporating an N-methoxy imidoyl halide or nitrile functionality, Bioorg. Med. Chem. Lett. 2(8):791-796 (1992). DMF8IA6 RU http://www.sciencedirect.com/science/article/pii/S0960894X00805338 DMF8IA6 DI DMF8IA6 DMF8IA6 DN N-methoxyquinuclidine-3-carboximidoyl fluoride DMF8IA6 MI TTQ13Z5 DMF8IA6 MN Muscarinic acetylcholine receptor M3 (CHRM3) DMF8IA6 MT DTT DMF8IA6 MA Inhibitor DMF8IA6 RN A novel and selective class of azabicyclic muscarinic agonists incorporating an N-methoxy imidoyl halide or nitrile functionality, Bioorg. Med. Chem. Lett. 2(8):791-796 (1992). DMF8IA6 RU http://www.sciencedirect.com/science/article/pii/S0960894X00805338 DMF8IA6 DI DMF8IA6 DMF8IA6 DN N-methoxyquinuclidine-3-carboximidoyl fluoride DMF8IA6 MI TTQ3JTF DMF8IA6 MN Muscarinic acetylcholine receptor M4 (CHRM4) DMF8IA6 MT DTT DMF8IA6 MA Inhibitor DMF8IA6 RN A novel and selective class of azabicyclic muscarinic agonists incorporating an N-methoxy imidoyl halide or nitrile functionality, Bioorg. Med. Chem. Lett. 2(8):791-796 (1992). DMF8IA6 RU http://www.sciencedirect.com/science/article/pii/S0960894X00805338 DMF8IA6 DI DMF8IA6 DMF8IA6 DN N-methoxyquinuclidine-3-carboximidoyl fluoride DMF8IA6 MI TTH18TF DMF8IA6 MN Muscarinic acetylcholine receptor M5 (CHRM5) DMF8IA6 MT DTT DMF8IA6 MA Inhibitor DMF8IA6 RN A novel and selective class of azabicyclic muscarinic agonists incorporating an N-methoxy imidoyl halide or nitrile functionality, Bioorg. Med. Chem. Lett. 2(8):791-796 (1992). DMF8IA6 RU http://www.sciencedirect.com/science/article/pii/S0960894X00805338 DM32YID DI DM32YID DM32YID DN N-methyl estradiol-16-methyl carboxamide DM32YID MI TTIWB6L DM32YID MN Estradiol 17 beta-dehydrogenase 1 (17-beta-HSD1) DM32YID MT DTT DM32YID MA Inhibitor DM32YID RN Modification of estrone at the 6, 16, and 17 positions: novel potent inhibitors of 17beta-hydroxysteroid dehydrogenase type 1. J Med Chem. 2006 Feb 23;49(4):1325-45. DM32YID RU https://pubmed.ncbi.nlm.nih.gov/16480268 DM7XIK5 DI DM7XIK5 DM7XIK5 DN N-methyl estrone-16-methyl carboxamide DM7XIK5 MI TTIWB6L DM7XIK5 MN Estradiol 17 beta-dehydrogenase 1 (17-beta-HSD1) DM7XIK5 MT DTT DM7XIK5 MA Inhibitor DM7XIK5 RN Modification of estrone at the 6, 16, and 17 positions: novel potent inhibitors of 17beta-hydroxysteroid dehydrogenase type 1. J Med Chem. 2006 Feb 23;49(4):1325-45. DM7XIK5 RU https://pubmed.ncbi.nlm.nih.gov/16480268 DM6XYCU DI DM6XYCU DM6XYCU DN N-methyl LTC4 DM6XYCU MI TTGKOY9 DM6XYCU MN Leukotriene CysLT1 receptor (CYSLTR1) DM6XYCU MT DTT DM6XYCU MA Agonist DM6XYCU RN Differential signaling of cysteinyl leukotrienes and a novel cysteinyl leukotriene receptor 2 (CysLT agonist, N-methyl-leukotriene C in calcium reporter and beta arrestin assays. Mol Pharmacol. 2011 Feb;79(2):270-8. DM6XYCU RU https://pubmed.ncbi.nlm.nih.gov/21078884 DM6XYCU DI DM6XYCU DM6XYCU DN N-methyl LTC4 DM6XYCU MI TT0PZR5 DM6XYCU MN Leukotriene CysLT2 receptor (CYSLTR2) DM6XYCU MT DTT DM6XYCU MA Agonist DM6XYCU RN Differential signaling of cysteinyl leukotrienes and a novel cysteinyl leukotriene receptor 2 (CysLT agonist, N-methyl-leukotriene C in calcium reporter and beta arrestin assays. Mol Pharmacol. 2011 Feb;79(2):270-8. DM6XYCU RU https://pubmed.ncbi.nlm.nih.gov/21078884 DMXGY4F DI DMXGY4F DMXGY4F DN N-methyl ryanodine-succinamidate DMXGY4F MI TTU5CIX DMXGY4F MN Ryanodine receptor 1 (RYR1) DMXGY4F MT DTT DMXGY4F MA Inhibitor DMXGY4F RN Amino- and guanidinoacylryanodines: basic ryanodine esters with enhanced affinity for the sarcoplasmic reticulum Ca(2+)-release channel. J Med Chem. 1993 May 14;36(10):1319-23. DMXGY4F RU https://pubmed.ncbi.nlm.nih.gov/8388466 DM83AEM DI DM83AEM DM83AEM DN N-methyl,N-(benzyl),N-(pyrrol-2-ylmethyl)amine DM83AEM MI TT3WG5C DM83AEM MN Monoamine oxidase type A (MAO-A) DM83AEM MT DTT DM83AEM MA Inhibitor DM83AEM RN New pyrrole inhibitors of monoamine oxidase: synthesis, biological evaluation, and structural determinants of MAO-A and MAO-B selectivity. J Med Chem. 2007 Mar 8;50(5):922-31. DM83AEM RU https://pubmed.ncbi.nlm.nih.gov/17256833 DM83AEM DI DM83AEM DM83AEM DN N-methyl,N-(benzyl),N-(pyrrol-2-ylmethyl)amine DM83AEM MI TTGP7BY DM83AEM MN Monoamine oxidase type B (MAO-B) DM83AEM MT DTT DM83AEM MA Inhibitor DM83AEM RN New pyrrole inhibitors of monoamine oxidase: synthesis, biological evaluation, and structural determinants of MAO-A and MAO-B selectivity. J Med Chem. 2007 Mar 8;50(5):922-31. DM83AEM RU https://pubmed.ncbi.nlm.nih.gov/17256833 DMZ24XT DI DMZ24XT DMZ24XT DN N-methyl,N-(propargyl),N-(pyrrol-2-ylmethyl)amine DMZ24XT MI TT3WG5C DMZ24XT MN Monoamine oxidase type A (MAO-A) DMZ24XT MT DTT DMZ24XT MA Inhibitor DMZ24XT RN New pyrrole inhibitors of monoamine oxidase: synthesis, biological evaluation, and structural determinants of MAO-A and MAO-B selectivity. J Med Chem. 2007 Mar 8;50(5):922-31. DMZ24XT RU https://pubmed.ncbi.nlm.nih.gov/17256833 DMZ24XT DI DMZ24XT DMZ24XT DN N-methyl,N-(propargyl),N-(pyrrol-2-ylmethyl)amine DMZ24XT MI TTGP7BY DMZ24XT MN Monoamine oxidase type B (MAO-B) DMZ24XT MT DTT DMZ24XT MA Inhibitor DMZ24XT RN New pyrrole inhibitors of monoamine oxidase: synthesis, biological evaluation, and structural determinants of MAO-A and MAO-B selectivity. J Med Chem. 2007 Mar 8;50(5):922-31. DMZ24XT RU https://pubmed.ncbi.nlm.nih.gov/17256833 DMM3B21 DI DMM3B21 DMM3B21 DN N-Methyl,N-phenyl-1H-indole-2-carboxamide DMM3B21 MI TT3WG5C DMM3B21 MN Monoamine oxidase type A (MAO-A) DMM3B21 MT DTT DMM3B21 MA Inhibitor DMM3B21 RN Synthesis, structure-activity relationships and molecular modeling studies of new indole inhibitors of monoamine oxidases A and B. Bioorg Med Chem. 2008 Nov 15;16(22):9729-40. DMM3B21 RU https://pubmed.ncbi.nlm.nih.gov/18951803 DMM3B21 DI DMM3B21 DMM3B21 DN N-Methyl,N-phenyl-1H-indole-2-carboxamide DMM3B21 MI TTGP7BY DMM3B21 MN Monoamine oxidase type B (MAO-B) DMM3B21 MT DTT DMM3B21 MA Inhibitor DMM3B21 RN Synthesis, structure-activity relationships and molecular modeling studies of new indole inhibitors of monoamine oxidases A and B. Bioorg Med Chem. 2008 Nov 15;16(22):9729-40. DMM3B21 RU https://pubmed.ncbi.nlm.nih.gov/18951803 DMUJ18P DI DMUJ18P DMUJ18P DN N-methyl-1-(2-thiophen-2-ylphenyl)methanamine DMUJ18P MI TTXZEAJ DMUJ18P MN Leukotriene A-4 hydrolase (LTA4H) DMUJ18P MT DTT DMUJ18P MA Inhibitor DMUJ18P RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DMUJ18P RU https://pubmed.ncbi.nlm.nih.gov/10592235 DMK8VZM DI DMK8VZM DMK8VZM DN N-Methyl-1'H-phenothiazine-1'-carboxamide DMK8VZM MI TT1RS9F DMK8VZM MN Acetylcholinesterase (AChE) DMK8VZM MT DTT DMK8VZM MA Inhibitor DMK8VZM RN Differential binding of phenothiazine urea derivatives to wild-type human cholinesterases and butyrylcholinesterase mutants. Bioorg Med Chem. 2010 Mar 15;18(6):2232-2244. DMK8VZM RU https://pubmed.ncbi.nlm.nih.gov/20181484 DMK8VZM DI DMK8VZM DMK8VZM DN N-Methyl-1'H-phenothiazine-1'-carboxamide DMK8VZM MI TTEB0GD DMK8VZM MN Cholinesterase (BCHE) DMK8VZM MT DTT DMK8VZM MA Inhibitor DMK8VZM RN Differential binding of phenothiazine urea derivatives to wild-type human cholinesterases and butyrylcholinesterase mutants. Bioorg Med Chem. 2010 Mar 15;18(6):2232-2244. DMK8VZM RU https://pubmed.ncbi.nlm.nih.gov/20181484 DM8LNMY DI DM8LNMY DM8LNMY DN N-methyl-2-(pyridin-2-yl)ethanamine DM8LNMY MI TT9JNIC DM8LNMY MN Histamine H3 receptor (H3R) DM8LNMY MT DTT DM8LNMY MA Inhibitor DM8LNMY RN 5-hydroxyindole-2-carboxylic acid amides: novel histamine-3 receptor inverse agonists for the treatment of obesity. J Med Chem. 2009 Jul 9;52(13):3855-68. DM8LNMY RU https://pubmed.ncbi.nlm.nih.gov/19456097 DMXS43P DI DMXS43P DMXS43P DN N-methyl-2-(pyridin-3-yloxy)ethanamine DMXS43P MI TT4H1MQ DMXS43P MN Neuronal acetylcholine receptor alpha-4 (CHRNA4) DMXS43P MT DTT DMXS43P MA Inhibitor DMXS43P RN Synthesis and analgesic activity of secondary amine analogues of pyridylmethylamine and positional isomeric analogues of ABT-594. Bioorg Med Chem Lett. 2006 Apr 1;16(7):2013-6. DMXS43P RU https://pubmed.ncbi.nlm.nih.gov/16412637 DMXS43P DI DMXS43P DMXS43P DN N-methyl-2-(pyridin-3-yloxy)ethanamine DMXS43P MI TT5KPZR DMXS43P MN Neuronal acetylcholine receptor beta-2 (CHRNB2) DMXS43P MT DTT DMXS43P MA Inhibitor DMXS43P RN Synthesis and analgesic activity of secondary amine analogues of pyridylmethylamine and positional isomeric analogues of ABT-594. Bioorg Med Chem Lett. 2006 Apr 1;16(7):2013-6. DMXS43P RU https://pubmed.ncbi.nlm.nih.gov/16412637 DMQGRMO DI DMQGRMO DMQGRMO DN N-methyl-2,2,2-triphenylacetamide DMQGRMO MI TTMNI76 DMQGRMO MN Calcium-activated potassium channel (KCN) DMQGRMO MT DTT DMQGRMO MA Inhibitor DMQGRMO RN Novel inhibitors of the Gardos channel for the treatment of sickle cell disease. J Med Chem. 2008 Feb 28;51(4):976-82. DMQGRMO RU https://pubmed.ncbi.nlm.nih.gov/18232633 DM8IHQP DI DM8IHQP DM8IHQP DN N-methyl-3,3-diphenylpropan-1-amine DM8IHQP MI TTJQOD7 DM8IHQP MN 5-HT 2A receptor (HTR2A) DM8IHQP MT DTT DM8IHQP MA Inhibitor DM8IHQP RN Synthesis, structure-affinity relationships, and modeling of AMDA analogs at 5-HT2A and H1 receptors: structural factors contributing to selectivity. Bioorg Med Chem. 2009 Sep 15;17(18):6496-504. DM8IHQP RU https://pubmed.ncbi.nlm.nih.gov/19700330 DM8IHQP DI DM8IHQP DM8IHQP DN N-methyl-3,3-diphenylpropan-1-amine DM8IHQP MI TTTIBOJ DM8IHQP MN Histamine H1 receptor (H1R) DM8IHQP MT DTT DM8IHQP MA Inhibitor DM8IHQP RN Synthesis, structure-affinity relationships, and modeling of AMDA analogs at 5-HT2A and H1 receptors: structural factors contributing to selectivity. Bioorg Med Chem. 2009 Sep 15;17(18):6496-504. DM8IHQP RU https://pubmed.ncbi.nlm.nih.gov/19700330 DMMNIRC DI DMMNIRC DMMNIRC DN N-methyl-4-(pyridin-3-yl)but-3-yn-1-amine DMMNIRC MI TT4H1MQ DMMNIRC MN Neuronal acetylcholine receptor alpha-4 (CHRNA4) DMMNIRC MT DTT DMMNIRC MA Inhibitor DMMNIRC RN Synthesis and analgesic activity of secondary amine analogues of pyridylmethylamine and positional isomeric analogues of ABT-594. Bioorg Med Chem Lett. 2006 Apr 1;16(7):2013-6. DMMNIRC RU https://pubmed.ncbi.nlm.nih.gov/16412637 DMMNIRC DI DMMNIRC DMMNIRC DN N-methyl-4-(pyridin-3-yl)but-3-yn-1-amine DMMNIRC MI TT5KPZR DMMNIRC MN Neuronal acetylcholine receptor beta-2 (CHRNB2) DMMNIRC MT DTT DMMNIRC MA Inhibitor DMMNIRC RN Synthesis and analgesic activity of secondary amine analogues of pyridylmethylamine and positional isomeric analogues of ABT-594. Bioorg Med Chem Lett. 2006 Apr 1;16(7):2013-6. DMMNIRC RU https://pubmed.ncbi.nlm.nih.gov/16412637 DMO3PNF DI DMO3PNF DMO3PNF DN N-methyl-4,4-diphenylbutan-1-amine DMO3PNF MI TTJQOD7 DMO3PNF MN 5-HT 2A receptor (HTR2A) DMO3PNF MT DTT DMO3PNF MA Inhibitor DMO3PNF RN Synthesis, structure-affinity relationships, and modeling of AMDA analogs at 5-HT2A and H1 receptors: structural factors contributing to selectivity. Bioorg Med Chem. 2009 Sep 15;17(18):6496-504. DMO3PNF RU https://pubmed.ncbi.nlm.nih.gov/19700330 DMO3PNF DI DMO3PNF DMO3PNF DN N-methyl-4,4-diphenylbutan-1-amine DMO3PNF MI TTTIBOJ DMO3PNF MN Histamine H1 receptor (H1R) DMO3PNF MT DTT DMO3PNF MA Inhibitor DMO3PNF RN Synthesis, structure-affinity relationships, and modeling of AMDA analogs at 5-HT2A and H1 receptors: structural factors contributing to selectivity. Bioorg Med Chem. 2009 Sep 15;17(18):6496-504. DMO3PNF RU https://pubmed.ncbi.nlm.nih.gov/19700330 DMA0YGE DI DMA0YGE DMA0YGE DN N-methyl-4-pentyl-N-(pyridin-3-yl)benzamide DMA0YGE MI TTMI6F5 DMA0YGE MN Transient receptor potential cation channel V1 (TRPV1) DMA0YGE MT DTT DMA0YGE MA Inhibitor DMA0YGE RN N-pyridin-3-yl- and N-quinolin-3-yl-benzamides: modulators of human vanilloid receptor 1 (TRPV1). Bioorg Med Chem Lett. 2008 Apr 15;18(8):2730-4. DMA0YGE RU https://pubmed.ncbi.nlm.nih.gov/18359227 DMD621E DI DMD621E DMD621E DN N-methyl-5,6-dip-tolylpyrazine-2-carboxamide DMD621E MI TT6OEDT DMD621E MN Cannabinoid receptor 1 (CB1) DMD621E MT DTT DMD621E MA Inhibitor DMD621E RN Discovery of pyrazine carboxamide CB1 antagonists: the introduction of a hydroxyl group improves the pharmaceutical properties and in vivo efficacy... Bioorg Med Chem Lett. 2007 Jul 15;17(14):3978-82. DMD621E RU https://pubmed.ncbi.nlm.nih.gov/17513109 DM5GXIS DI DM5GXIS DM5GXIS DN N-methylbicuculline DM5GXIS MI TTAN6JD DM5GXIS MN Glutamate receptor AMPA (GRIA) DM5GXIS MT DTT DM5GXIS MA Antagonist DM5GXIS RN GABA receptors modulate trigeminovascular nociceptive neurotransmission in the trigeminocervical complex. Br J Pharmacol. 2001 Oct;134(4):896-904. DM5GXIS RU https://pubmed.ncbi.nlm.nih.gov/11606331 DMP1EF6 DI DMP1EF6 DMP1EF6 DN N-Methyl-ETAV DMP1EF6 MI TT9PB26 DMP1EF6 MN Presynaptic density protein 95 (DLG4) DMP1EF6 MT DTT DMP1EF6 MA Inhibitor DMP1EF6 RN Modified peptides as potent inhibitors of the postsynaptic density-95/N-methyl-D-aspartate receptor interaction. J Med Chem. 2008 Oct 23;51(20):6450-9. DMP1EF6 RU https://pubmed.ncbi.nlm.nih.gov/18811137 DMCFH5W DI DMCFH5W DMCFH5W DN N-methylhistamine DMCFH5W MI TT9JNIC DMCFH5W MN Histamine H3 receptor (H3R) DMCFH5W MT DTT DMCFH5W MA Agonist DMCFH5W RN Cloning and pharmacological characterization of a fourth histamine receptor (H(4)) expressed in bone marrow. Mol Pharmacol. 2001 Mar;59(3):420-6. DMCFH5W RU https://pubmed.ncbi.nlm.nih.gov/11179434 DMCFH5W DI DMCFH5W DMCFH5W DN N-methylhistamine DMCFH5W MI TTXJ178 DMCFH5W MN Histamine H4 receptor (H4R) DMCFH5W MT DTT DMCFH5W MA Agonist DMCFH5W RN Comparison of human, mouse, rat, and guinea pig histamine H4 receptors reveals substantial pharmacological species variation. J Pharmacol Exp Ther. 2001 Oct;299(1):121-30. DMCFH5W RU https://pubmed.ncbi.nlm.nih.gov/11561071 DMWPBKU DI DMWPBKU DMWPBKU DN N-methyllaurotetanine DMWPBKU MI TTSQIFT DMWPBKU MN 5-HT 1A receptor (HTR1A) DMWPBKU MT DTT DMWPBKU MA Inhibitor DMWPBKU RN Alkaloids from Eschscholzia californica and their capacity to inhibit binding of [3H]8-Hydroxy-2-(di-N-propylamino)tetralin to 5-HT1A receptors in ... J Nat Prod. 2006 Mar;69(3):432-5. DMWPBKU RU https://pubmed.ncbi.nlm.nih.gov/16562853 DM9AGCV DI DM9AGCV DM9AGCV DN N-Methylleucine DM9AGCV MI TTQOVYA DM9AGCV MN C-X-C motif chemokine 10 (CXCL10) DM9AGCV MT DTT DM9AGCV MA Inhibitor DM9AGCV RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DM9AGCV RU https://pubmed.ncbi.nlm.nih.gov/17139284 DM4FMZP DI DM4FMZP DM4FMZP DN N-Methylmesoporphyrin DM4FMZP MI TTQ6VF4 DM4FMZP MN Ferrochelatase (FECH) DM4FMZP MT DTT DM4FMZP MA Inhibitor DM4FMZP RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DM4FMZP RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMKZL5H DI DMKZL5H DMKZL5H DN N-Methylmesoporphyrin Containing Copper DMKZL5H MI TTQ6VF4 DMKZL5H MN Ferrochelatase (FECH) DMKZL5H MT DTT DMKZL5H MA Inhibitor DMKZL5H RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMKZL5H RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMYPEX3 DI DMYPEX3 DMYPEX3 DN N-Methyl-N-(Methylbenzyl)Formamide DMYPEX3 MI TTB2MXP DMYPEX3 MN Angiotensinogenase renin (REN) DMYPEX3 MT DTT DMYPEX3 MA Inhibitor DMYPEX3 RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DMYPEX3 RU https://pubmed.ncbi.nlm.nih.gov/10592235 DMYPEX3 DI DMYPEX3 DMYPEX3 DN N-Methyl-N-(Methylbenzyl)Formamide DMYPEX3 MI DEVDYN7 DMYPEX3 MN Cytochrome P450 2E1 (CYP2E1) DMYPEX3 MT DME DMYPEX3 MA Metabolism DMYPEX3 RN Drug Interactions Flockhart Table DMYPEX3 RU https://drug-interactions.medicine.iu.edu/Main-Table.aspx DM796AX DI DM796AX DM796AX DN N-methyl-N-(prop-2-ynyl)-1H-pyrrole-2-carboxamide DM796AX MI TT3WG5C DM796AX MN Monoamine oxidase type A (MAO-A) DM796AX MT DTT DM796AX MA Inhibitor DM796AX RN New pyrrole inhibitors of monoamine oxidase: synthesis, biological evaluation, and structural determinants of MAO-A and MAO-B selectivity. J Med Chem. 2007 Mar 8;50(5):922-31. DM796AX RU https://pubmed.ncbi.nlm.nih.gov/17256833 DMOP128 DI DMOP128 DMOP128 DN N-methyl-N-(pyridin-3-ylmethyl)ethanamine DMOP128 MI TT4H1MQ DMOP128 MN Neuronal acetylcholine receptor alpha-4 (CHRNA4) DMOP128 MT DTT DMOP128 MA Inhibitor DMOP128 RN Synthesis and analgesic activity of secondary amine analogues of pyridylmethylamine and positional isomeric analogues of ABT-594. Bioorg Med Chem Lett. 2006 Apr 1;16(7):2013-6. DMOP128 RU https://pubmed.ncbi.nlm.nih.gov/16412637 DMOP128 DI DMOP128 DMOP128 DN N-methyl-N-(pyridin-3-ylmethyl)ethanamine DMOP128 MI TT5KPZR DMOP128 MN Neuronal acetylcholine receptor beta-2 (CHRNB2) DMOP128 MT DTT DMOP128 MA Inhibitor DMOP128 RN Synthesis and analgesic activity of secondary amine analogues of pyridylmethylamine and positional isomeric analogues of ABT-594. Bioorg Med Chem Lett. 2006 Apr 1;16(7):2013-6. DMOP128 RU https://pubmed.ncbi.nlm.nih.gov/16412637 DMXSJH0 DI DMXSJH0 DMXSJH0 DN N-Methylnaloxonium DMXSJH0 MI TTMF541 DMXSJH0 MN Liver carboxylesterase (CES1) DMXSJH0 MT DTT DMXSJH0 MA Inhibitor DMXSJH0 RN DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Nucleic Acids Res. 2011 Jan;39(Database issue):D1035-41. DMXSJH0 RU https://pubmed.ncbi.nlm.nih.gov/21059682 DM6DM4L DI DM6DM4L DM6DM4L DN N-methyl-N-ethyl estradiol-16-carboxamide DM6DM4L MI TTIWB6L DM6DM4L MN Estradiol 17 beta-dehydrogenase 1 (17-beta-HSD1) DM6DM4L MT DTT DM6DM4L MA Inhibitor DM6DM4L RN Modification of estrone at the 6, 16, and 17 positions: novel potent inhibitors of 17beta-hydroxysteroid dehydrogenase type 1. J Med Chem. 2006 Feb 23;49(4):1325-45. DM6DM4L RU https://pubmed.ncbi.nlm.nih.gov/16480268 DM2CUEB DI DM2CUEB DM2CUEB DN N-methyl-N-ethyl estrone-16-methyl carboxamide DM2CUEB MI TTIWB6L DM2CUEB MN Estradiol 17 beta-dehydrogenase 1 (17-beta-HSD1) DM2CUEB MT DTT DM2CUEB MA Inhibitor DM2CUEB RN Modification of estrone at the 6, 16, and 17 positions: novel potent inhibitors of 17beta-hydroxysteroid dehydrogenase type 1. J Med Chem. 2006 Feb 23;49(4):1325-45. DM2CUEB RU https://pubmed.ncbi.nlm.nih.gov/16480268 DMDB7ZM DI DMDB7ZM DMDB7ZM DN N-Methyl-N-phenyl-2-oxo-2H-chromene-3-carboxamide DMDB7ZM MI TTGP7BY DMDB7ZM MN Monoamine oxidase type B (MAO-B) DMDB7ZM MT DTT DMDB7ZM MA Inhibitor DMDB7ZM RN Synthesis, molecular modeling, and selective inhibitory activity against human monoamine oxidases of 3-carboxamido-7-substituted coumarins. J Med Chem. 2009 Apr 9;52(7):1935-42. DMDB7ZM RU https://pubmed.ncbi.nlm.nih.gov/19267475 DMB9OGI DI DMB9OGI DMB9OGI DN N-Methyl-N-Propargyl-1(R)-Aminoindan DMB9OGI MI TTGP7BY DMB9OGI MN Monoamine oxidase type B (MAO-B) DMB9OGI MT DTT DMB9OGI MA Inhibitor DMB9OGI RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DMB9OGI RU https://pubmed.ncbi.nlm.nih.gov/10592235 DMDAN0K DI DMDAN0K DMDAN0K DN N-methyl-Pip-F-homoF-vinyl sulfonyl phenyl (N-methyl-Pip-F-hF-VS phi) DMDAN0K MI TTO9X1H DMDAN0K MN 5-HT 7 receptor (HTR7) DMDAN0K MT DTT DMDAN0K MA Antagonist DMDAN0K RN 5-HT7 receptors. Curr Drug Targets CNS Neurol Disord. 2004 Feb;3(1):81-90. DMDAN0K RU https://pubmed.ncbi.nlm.nih.gov/14965246 DMDAN0K DI DMDAN0K DMDAN0K DN N-methyl-Pip-F-homoF-vinyl sulfonyl phenyl (N-methyl-Pip-F-hF-VS phi) DMDAN0K MI TT2SUAQ DMDAN0K MN Cysteine protease (CYP) DMDAN0K MT DTT DMDAN0K MA Inhibitor DMDAN0K RN A cysteine protease inhibitor cures Chagas' disease in an immunodeficient-mouse model of infection. Antimicrob Agents Chemother. 2007 Nov;51(11):3932-9. DMDAN0K RU https://pubmed.ncbi.nlm.nih.gov/17698625 DMZYSM1 DI DMZYSM1 DMZYSM1 DN N-methylstephisoferulin DMZYSM1 MI TT27RFC DMZYSM1 MN Opioid receptor delta (OPRD1) DMZYSM1 MT DTT DMZYSM1 MA Inhibitor DMZYSM1 RN Hasubanan alkaloids with delta-opioid binding affinity from the aerial parts of Stephania japonica. J Nat Prod. 2010 May 28;73(5):988-91. DMZYSM1 RU https://pubmed.ncbi.nlm.nih.gov/20426456 DM5CR2E DI DM5CR2E DM5CR2E DN N-methylstephuline DM5CR2E MI TT27RFC DM5CR2E MN Opioid receptor delta (OPRD1) DM5CR2E MT DTT DM5CR2E MA Inhibitor DM5CR2E RN Hasubanan alkaloids with delta-opioid binding affinity from the aerial parts of Stephania japonica. J Nat Prod. 2010 May 28;73(5):988-91. DM5CR2E RU https://pubmed.ncbi.nlm.nih.gov/20426456 DMS8H5Q DI DMS8H5Q DMS8H5Q DN NM-PP1 DMS8H5Q MI TT860QF DMS8H5Q MN LCK tyrosine protein kinase (LCK) DMS8H5Q MT DTT DMS8H5Q MA Inhibitor DMS8H5Q RN The selectivity of protein kinase inhibitors: a further update. Biochem J. 2007 Dec 15;408(3):297-315. DMS8H5Q RU https://pubmed.ncbi.nlm.nih.gov/17850214 DMS8H5Q DI DMS8H5Q DMS8H5Q DN NM-PP1 DMS8H5Q MI TT5U49F DMS8H5Q MN PRKACA messenger RNA (PRKACA mRNA) DMS8H5Q MT DTT DMS8H5Q MA Inhibitor DMS8H5Q RN The selectivity of protein kinase inhibitors: a further update. Biochem J. 2007 Dec 15;408(3):297-315. DMS8H5Q RU https://pubmed.ncbi.nlm.nih.gov/17850214 DMS8H5Q DI DMS8H5Q DMS8H5Q DN NM-PP1 DMS8H5Q MI TT6PKBN DMS8H5Q MN Proto-oncogene c-Src (SRC) DMS8H5Q MT DTT DMS8H5Q MA Inhibitor DMS8H5Q RN The selectivity of protein kinase inhibitors: a further update. Biochem J. 2007 Dec 15;408(3):297-315. DMS8H5Q RU https://pubmed.ncbi.nlm.nih.gov/17850214 DMS8H5Q DI DMS8H5Q DMS8H5Q DN NM-PP1 DMS8H5Q MI TTCQ2E5 DMS8H5Q MN RIP2 messenger RNA (RIP2 mRNA) DMS8H5Q MT DTT DMS8H5Q MA Inhibitor DMS8H5Q RN The selectivity of protein kinase inhibitors: a further update. Biochem J. 2007 Dec 15;408(3):297-315. DMS8H5Q RU https://pubmed.ncbi.nlm.nih.gov/17850214 DMS8H5Q DI DMS8H5Q DMS8H5Q DN NM-PP1 DMS8H5Q MI TT0K6EO DMS8H5Q MN Stress-activated protein kinase JNK1 (JNK1) DMS8H5Q MT DTT DMS8H5Q MA Inhibitor DMS8H5Q RN The selectivity of protein kinase inhibitors: a further update. Biochem J. 2007 Dec 15;408(3):297-315. DMS8H5Q RU https://pubmed.ncbi.nlm.nih.gov/17850214 DMX4ZGL DI DMX4ZGL DMX4ZGL DN NMS-1 DMX4ZGL MI TTIYVQP DMX4ZGL MN Polo-like kinase 1 (PLK1) DMX4ZGL MT DTT DMX4ZGL MA Inhibitor DMX4ZGL RN Polo-like kinase (PLK) inhibitors in preclinical and early clinical development in oncology. Oncologist. 2009 Jun;14(6):559-70. DMX4ZGL RU https://pubmed.ncbi.nlm.nih.gov/19474163 DMYKZ6U DI DMYKZ6U DMYKZ6U DN NMS-873 DMYKZ6U MI TTYWTI0 DMYKZ6U MN HUMAN valosin-containing protein p97 (VCP) DMYKZ6U MT DTT DMYKZ6U MA Inhibitor DMYKZ6U RN A SARS-CoV-2 Protein Interaction Map Reveals Targets for Drug Repurposing. Nature. 2020 Apr 30. doi: 10.1038/s41586-020-2286-9. DMYKZ6U RU https://pubmed.ncbi.nlm.nih.gov/32353859 DMSQ4TL DI DMSQ4TL DMSQ4TL DN NNC 11-1314 DMSQ4TL MI TTOXS3C DMSQ4TL MN Muscarinic acetylcholine receptor (CHRM) DMSQ4TL MT DTT DMSQ4TL MA Agonist DMSQ4TL RN Synthesis and pharmacological evaluation of dimeric muscarinic acetylcholine receptor agonists. J Pharmacol Exp Ther. 2001 Sep;298(3):1260-8. DMSQ4TL RU https://pubmed.ncbi.nlm.nih.gov/11504829 DMSQ4TL DI DMSQ4TL DMSQ4TL DN NNC 11-1314 DMSQ4TL MI TTQ13Z5 DMSQ4TL MN Muscarinic acetylcholine receptor M3 (CHRM3) DMSQ4TL MT DTT DMSQ4TL MA Agonist DMSQ4TL RN Synthesis and pharmacological evaluation of dimeric muscarinic acetylcholine receptor agonists. J Pharmacol Exp Ther. 2001 Sep;298(3):1260-8. DMSQ4TL RU https://pubmed.ncbi.nlm.nih.gov/11504829 DMMX19B DI DMMX19B DMMX19B DN NNC 11-1585 DMMX19B MI TTOXS3C DMMX19B MN Muscarinic acetylcholine receptor (CHRM) DMMX19B MT DTT DMMX19B MA Agonist DMMX19B RN Synthesis and pharmacological evaluation of dimeric muscarinic acetylcholine receptor agonists. J Pharmacol Exp Ther. 2001 Sep;298(3):1260-8. DMMX19B RU https://pubmed.ncbi.nlm.nih.gov/11504829 DMMX19B DI DMMX19B DMMX19B DN NNC 11-1585 DMMX19B MI TTQ13Z5 DMMX19B MN Muscarinic acetylcholine receptor M3 (CHRM3) DMMX19B MT DTT DMMX19B MA Agonist DMMX19B RN Synthesis and pharmacological evaluation of dimeric muscarinic acetylcholine receptor agonists. J Pharmacol Exp Ther. 2001 Sep;298(3):1260-8. DMMX19B RU https://pubmed.ncbi.nlm.nih.gov/11504829 DMZJSWI DI DMZJSWI DMZJSWI DN NNC 11-1607 DMZJSWI MI TTOXS3C DMZJSWI MN Muscarinic acetylcholine receptor (CHRM) DMZJSWI MT DTT DMZJSWI MA Agonist DMZJSWI RN Synthesis and pharmacological evaluation of dimeric muscarinic acetylcholine receptor agonists. J Pharmacol Exp Ther. 2001 Sep;298(3):1260-8. DMZJSWI RU https://pubmed.ncbi.nlm.nih.gov/11504829 DMZJSWI DI DMZJSWI DMZJSWI DN NNC 11-1607 DMZJSWI MI TTQ13Z5 DMZJSWI MN Muscarinic acetylcholine receptor M3 (CHRM3) DMZJSWI MT DTT DMZJSWI MA Agonist DMZJSWI RN Synthesis and pharmacological evaluation of dimeric muscarinic acetylcholine receptor agonists. J Pharmacol Exp Ther. 2001 Sep;298(3):1260-8. DMZJSWI RU https://pubmed.ncbi.nlm.nih.gov/11504829 DM0C8N3 DI DM0C8N3 DM0C8N3 DN NNC 711 DM0C8N3 MI TTV9MQG DM0C8N3 MN Gamma-aminobutyric acid uptake (GABAU) DM0C8N3 MT DTT DM0C8N3 MA Inhibitor DM0C8N3 RN Effects of NNC 711, a GABA uptake inhibitor, on pentylenetetrazol-induced seizures in developing and adult rats. Naunyn Schmiedebergs Arch Pharmacol. 1998 Sep;358(3):334-41. DM0C8N3 RU https://pubmed.ncbi.nlm.nih.gov/9774221 DMPQ1HL DI DMPQ1HL DMPQ1HL DN NNC 92-1687 DMPQ1HL MI TT9O6WS DMPQ1HL MN Glucagon receptor (GCGR) DMPQ1HL MT DTT DMPQ1HL MA Antagonist DMPQ1HL RN Discovery and structure-activity relationship of the first non-peptide competitive human glucagon receptor antagonists. J Med Chem. 1998 Dec 17;41(26):5150-7. DMPQ1HL RU https://pubmed.ncbi.nlm.nih.gov/9857085 DMCGF3U DI DMCGF3U DMCGF3U DN NNC052090 DMCGF3U MI TTQBMPI DMCGF3U MN Na(+)/Cl(-) betaine/GABA transporter (SLC6A12) DMCGF3U MT DTT DMCGF3U MA Inhibitor DMCGF3U RN 1-(3-(9H-carbazol-9-yl)-1-propyl)-4-(2-methoxyphenyl)-4-piperidinol, a novel subtype selective inhibitor of the mouse type II GABA-transporter. Br J Pharmacol. 1997 Mar;120(6):983-5. DMCGF3U RU https://pubmed.ncbi.nlm.nih.gov/9134205 DMDCPFJ DI DMDCPFJ DMDCPFJ DN NNC-26-0194 DMDCPFJ MI TTKMAZ6 DMDCPFJ MN Growth hormone receptor (GHR) DMDCPFJ MT DTT DMDCPFJ MA Modulator DMDCPFJ RN Pharmacokinetic evaluation of ipamorelin and other peptidyl growth hormone secretagogues with emphasis on nasal absorption. Xenobiotica. 1998 Nov;28(11):1083-92. DMDCPFJ RU https://www.ncbi.nlm.nih.gov/pubmed/9879640 DMAQTW3 DI DMAQTW3 DMAQTW3 DN NNC269100 DMAQTW3 MI TTAE1BR DMAQTW3 MN Somatostatin receptor type 4 (SSTR4) DMAQTW3 MT DTT DMAQTW3 MA Agonist DMAQTW3 RN Nonpeptide somatostatin agonists with sst4 selectivity: synthesis and structure-activity relationships of thioureas. J Med Chem. 1998 Nov 19;41(24):4693-705. DMAQTW3 RU https://pubmed.ncbi.nlm.nih.gov/9822540 DMID3F7 DI DMID3F7 DMID3F7 DN NNC55-0396 DMID3F7 MI TTWOCZI DMID3F7 MN Cation channel sperm-associated protein (CatSper) DMID3F7 MT DTT DMID3F7 MA Blocker (channel blocker) DMID3F7 RN The CatSper channel mediates progesterone-induced Ca2+ influx in human sperm. Nature. 2011 Mar 17;471(7338):382-6. DMID3F7 RU https://pubmed.ncbi.nlm.nih.gov/21412338 DMID3F7 DI DMID3F7 DMID3F7 DN NNC55-0396 DMID3F7 MI TT5CISB DMID3F7 MN Cation channel sperm-associated protein 1 (CatSper1) DMID3F7 MT DTT DMID3F7 MA Blocker (channel blocker) DMID3F7 RN The CatSper channel mediates progesterone-induced Ca2+ influx in human sperm. Nature. 2011 Mar 17;471(7338):382-6. DMID3F7 RU https://pubmed.ncbi.nlm.nih.gov/21412338 DMID3F7 DI DMID3F7 DMID3F7 DN NNC55-0396 DMID3F7 MI TTOEGC4 DMID3F7 MN Cation channel sperm-associated protein 2 (CatSper2) DMID3F7 MT DTT DMID3F7 MA Blocker (channel blocker) DMID3F7 RN The CatSper channel mediates progesterone-induced Ca2+ influx in human sperm. Nature. 2011 Mar 17;471(7338):382-6. DMID3F7 RU https://pubmed.ncbi.nlm.nih.gov/21412338 DMID3F7 DI DMID3F7 DMID3F7 DN NNC55-0396 DMID3F7 MI TTP52ZV DMID3F7 MN Cation channel sperm-associated protein 3 (CatSper3) DMID3F7 MT DTT DMID3F7 MA Blocker (channel blocker) DMID3F7 RN The CatSper channel mediates progesterone-induced Ca2+ influx in human sperm. Nature. 2011 Mar 17;471(7338):382-6. DMID3F7 RU https://pubmed.ncbi.nlm.nih.gov/21412338 DMUHZ23 DI DMUHZ23 DMUHZ23 DN N-N-diethyl estradiol-16-methyl carboxamide DMUHZ23 MI TTIWB6L DMUHZ23 MN Estradiol 17 beta-dehydrogenase 1 (17-beta-HSD1) DMUHZ23 MT DTT DMUHZ23 MA Inhibitor DMUHZ23 RN Modification of estrone at the 6, 16, and 17 positions: novel potent inhibitors of 17beta-hydroxysteroid dehydrogenase type 1. J Med Chem. 2006 Feb 23;49(4):1325-45. DMUHZ23 RU https://pubmed.ncbi.nlm.nih.gov/16480268 DMSYOHD DI DMSYOHD DMSYOHD DN NN-dimethyl-D-erythrosphingosine DMSYOHD MI TTO3TD8 DMSYOHD MN Long transient receptor potential channel 3 (TRPM3) DMSYOHD MT DTT DMSYOHD MA Activator DMSYOHD RN Activation of the melastatin-related cation channel TRPM3 by D-erythro-sphingosine [corrected]. Mol Pharmacol. 2005 Mar;67(3):798-805. DMSYOHD RU https://pubmed.ncbi.nlm.nih.gov/15550678 DM8FOSR DI DM8FOSR DM8FOSR DN N-n-dodecyl-7-methoxytacrine hydrochloride DM8FOSR MI TT1RS9F DM8FOSR MN Acetylcholinesterase (AChE) DM8FOSR MT DTT DM8FOSR MA Inhibitor DM8FOSR RN Synthesis and in vitro evaluation of N-alkyl-7-methoxytacrine hydrochlorides as potential cholinesterase inhibitors in Alzheimer disease. Bioorg Med Chem Lett. 2010 Oct 15;20(20):6093-5. DM8FOSR RU https://pubmed.ncbi.nlm.nih.gov/20817518 DMSUK2A DI DMSUK2A DMSUK2A DN N-Neopentyl-1'H-phenothiazine-1'-carboxamide DMSUK2A MI TTEB0GD DMSUK2A MN Cholinesterase (BCHE) DMSUK2A MT DTT DMSUK2A MA Inhibitor DMSUK2A RN Differential binding of phenothiazine urea derivatives to wild-type human cholinesterases and butyrylcholinesterase mutants. Bioorg Med Chem. 2010 Mar 15;18(6):2232-2244. DMSUK2A RU https://pubmed.ncbi.nlm.nih.gov/20181484 DMA8R47 DI DMA8R47 DMA8R47 DN N-n-heptyl-7-methoxytacrine hydrochloride DMA8R47 MI TT1RS9F DMA8R47 MN Acetylcholinesterase (AChE) DMA8R47 MT DTT DMA8R47 MA Inhibitor DMA8R47 RN Synthesis and in vitro evaluation of N-alkyl-7-methoxytacrine hydrochlorides as potential cholinesterase inhibitors in Alzheimer disease. Bioorg Med Chem Lett. 2010 Oct 15;20(20):6093-5. DMA8R47 RU https://pubmed.ncbi.nlm.nih.gov/20817518 DMA8R47 DI DMA8R47 DMA8R47 DN N-n-heptyl-7-methoxytacrine hydrochloride DMA8R47 MI TTEB0GD DMA8R47 MN Cholinesterase (BCHE) DMA8R47 MT DTT DMA8R47 MA Inhibitor DMA8R47 RN Synthesis and in vitro evaluation of N-alkyl-7-methoxytacrine hydrochlorides as potential cholinesterase inhibitors in Alzheimer disease. Bioorg Med Chem Lett. 2010 Oct 15;20(20):6093-5. DMA8R47 RU https://pubmed.ncbi.nlm.nih.gov/20817518 DM4ZMG6 DI DM4ZMG6 DM4ZMG6 DN N-n-hexyl-7-methoxytacrine hydrochloride DM4ZMG6 MI TT1RS9F DM4ZMG6 MN Acetylcholinesterase (AChE) DM4ZMG6 MT DTT DM4ZMG6 MA Inhibitor DM4ZMG6 RN Synthesis and in vitro evaluation of N-alkyl-7-methoxytacrine hydrochlorides as potential cholinesterase inhibitors in Alzheimer disease. Bioorg Med Chem Lett. 2010 Oct 15;20(20):6093-5. DM4ZMG6 RU https://pubmed.ncbi.nlm.nih.gov/20817518 DM4ZMG6 DI DM4ZMG6 DM4ZMG6 DN N-n-hexyl-7-methoxytacrine hydrochloride DM4ZMG6 MI TTEB0GD DM4ZMG6 MN Cholinesterase (BCHE) DM4ZMG6 MT DTT DM4ZMG6 MA Inhibitor DM4ZMG6 RN Synthesis and in vitro evaluation of N-alkyl-7-methoxytacrine hydrochlorides as potential cholinesterase inhibitors in Alzheimer disease. Bioorg Med Chem Lett. 2010 Oct 15;20(20):6093-5. DM4ZMG6 RU https://pubmed.ncbi.nlm.nih.gov/20817518 DMLH23M DI DMLH23M DMLH23M DN N-n-nonyl-7-methoxytacrine hydrochloride DMLH23M MI TT1RS9F DMLH23M MN Acetylcholinesterase (AChE) DMLH23M MT DTT DMLH23M MA Inhibitor DMLH23M RN Synthesis and in vitro evaluation of N-alkyl-7-methoxytacrine hydrochlorides as potential cholinesterase inhibitors in Alzheimer disease. Bioorg Med Chem Lett. 2010 Oct 15;20(20):6093-5. DMLH23M RU https://pubmed.ncbi.nlm.nih.gov/20817518 DMLH23M DI DMLH23M DMLH23M DN N-n-nonyl-7-methoxytacrine hydrochloride DMLH23M MI TTEB0GD DMLH23M MN Cholinesterase (BCHE) DMLH23M MT DTT DMLH23M MA Inhibitor DMLH23M RN Synthesis and in vitro evaluation of N-alkyl-7-methoxytacrine hydrochlorides as potential cholinesterase inhibitors in Alzheimer disease. Bioorg Med Chem Lett. 2010 Oct 15;20(20):6093-5. DMLH23M RU https://pubmed.ncbi.nlm.nih.gov/20817518 DMLC257 DI DMLC257 DMLC257 DN N-n-octyl-7-methoxytacrine hydrochloride DMLC257 MI TT1RS9F DMLC257 MN Acetylcholinesterase (AChE) DMLC257 MT DTT DMLC257 MA Inhibitor DMLC257 RN Synthesis and in vitro evaluation of N-alkyl-7-methoxytacrine hydrochlorides as potential cholinesterase inhibitors in Alzheimer disease. Bioorg Med Chem Lett. 2010 Oct 15;20(20):6093-5. DMLC257 RU https://pubmed.ncbi.nlm.nih.gov/20817518 DMLC257 DI DMLC257 DMLC257 DN N-n-octyl-7-methoxytacrine hydrochloride DMLC257 MI TTEB0GD DMLC257 MN Cholinesterase (BCHE) DMLC257 MT DTT DMLC257 MA Inhibitor DMLC257 RN Synthesis and in vitro evaluation of N-alkyl-7-methoxytacrine hydrochlorides as potential cholinesterase inhibitors in Alzheimer disease. Bioorg Med Chem Lett. 2010 Oct 15;20(20):6093-5. DMLC257 RU https://pubmed.ncbi.nlm.nih.gov/20817518 DMH3OUX DI DMH3OUX DMH3OUX DN N-nonylphenol DMH3OUX MI DE0P6LK DMH3OUX MN Sulfotransferase 2A1 (SULT2A1) DMH3OUX MT DME DMH3OUX MA Metabolism DMH3OUX RN Sulfation of environmental estrogens by cytosolic human sulfotransferases. Drug Metab Pharmacokinet. 2002;17(3):221-8. DMH3OUX RU https://www.ncbi.nlm.nih.gov/pubmed/?term=15618673 DMWAK5V DI DMWAK5V DMWAK5V DN N-n-pentyl-7-methoxytacrine hydrochloride DMWAK5V MI TT1RS9F DMWAK5V MN Acetylcholinesterase (AChE) DMWAK5V MT DTT DMWAK5V MA Inhibitor DMWAK5V RN Synthesis and in vitro evaluation of N-alkyl-7-methoxytacrine hydrochlorides as potential cholinesterase inhibitors in Alzheimer disease. Bioorg Med Chem Lett. 2010 Oct 15;20(20):6093-5. DMWAK5V RU https://pubmed.ncbi.nlm.nih.gov/20817518 DMWAK5V DI DMWAK5V DMWAK5V DN N-n-pentyl-7-methoxytacrine hydrochloride DMWAK5V MI TTEB0GD DMWAK5V MN Cholinesterase (BCHE) DMWAK5V MT DTT DMWAK5V MA Inhibitor DMWAK5V RN Synthesis and in vitro evaluation of N-alkyl-7-methoxytacrine hydrochlorides as potential cholinesterase inhibitors in Alzheimer disease. Bioorg Med Chem Lett. 2010 Oct 15;20(20):6093-5. DMWAK5V RU https://pubmed.ncbi.nlm.nih.gov/20817518 DMCN78A DI DMCN78A DMCN78A DN N-n-propyl-7-methoxytacrine hydrochloride DMCN78A MI TT1RS9F DMCN78A MN Acetylcholinesterase (AChE) DMCN78A MT DTT DMCN78A MA Inhibitor DMCN78A RN Synthesis and in vitro evaluation of N-alkyl-7-methoxytacrine hydrochlorides as potential cholinesterase inhibitors in Alzheimer disease. Bioorg Med Chem Lett. 2010 Oct 15;20(20):6093-5. DMCN78A RU https://pubmed.ncbi.nlm.nih.gov/20817518 DMN7GO8 DI DMN7GO8 DMN7GO8 DN NOCARDIMICIN A DMN7GO8 MI TTQ13Z5 DMN7GO8 MN Muscarinic acetylcholine receptor M3 (CHRM3) DMN7GO8 MT DTT DMN7GO8 MA Inhibitor DMN7GO8 RN Nocardimicins A, B, C, D, E, and F, siderophores with muscarinic M3 receptor inhibiting activity from Nocardia sp. TP-A0674. J Nat Prod. 2005 Jul;68(7):1061-5. DMN7GO8 RU https://pubmed.ncbi.nlm.nih.gov/16038549 DM4SRL7 DI DM4SRL7 DM4SRL7 DN Nocardimicin C DM4SRL7 MI TTQ13Z5 DM4SRL7 MN Muscarinic acetylcholine receptor M3 (CHRM3) DM4SRL7 MT DTT DM4SRL7 MA Inhibitor DM4SRL7 RN Nocardimicins A, B, C, D, E, and F, siderophores with muscarinic M3 receptor inhibiting activity from Nocardia sp. TP-A0674. J Nat Prod. 2005 Jul;68(7):1061-5. DM4SRL7 RU https://pubmed.ncbi.nlm.nih.gov/16038549 DM1SABZ DI DM1SABZ DM1SABZ DN Nocardimicin D DM1SABZ MI TTQ13Z5 DM1SABZ MN Muscarinic acetylcholine receptor M3 (CHRM3) DM1SABZ MT DTT DM1SABZ MA Inhibitor DM1SABZ RN Nocardimicins A, B, C, D, E, and F, siderophores with muscarinic M3 receptor inhibiting activity from Nocardia sp. TP-A0674. J Nat Prod. 2005 Jul;68(7):1061-5. DM1SABZ RU https://pubmed.ncbi.nlm.nih.gov/16038549 DMK02YC DI DMK02YC DMK02YC DN Nocardimicin F DMK02YC MI TTQ13Z5 DMK02YC MN Muscarinic acetylcholine receptor M3 (CHRM3) DMK02YC MT DTT DMK02YC MA Inhibitor DMK02YC RN Nocardimicins A, B, C, D, E, and F, siderophores with muscarinic M3 receptor inhibiting activity from Nocardia sp. TP-A0674. J Nat Prod. 2005 Jul;68(7):1061-5. DMK02YC RU https://pubmed.ncbi.nlm.nih.gov/16038549 DMXOF4Z DI DMXOF4Z DMXOF4Z DN Noccardimicin E DMXOF4Z MI TTQ13Z5 DMXOF4Z MN Muscarinic acetylcholine receptor M3 (CHRM3) DMXOF4Z MT DTT DMXOF4Z MA Inhibitor DMXOF4Z RN Nocardimicins A, B, C, D, E, and F, siderophores with muscarinic M3 receptor inhibiting activity from Nocardia sp. TP-A0674. J Nat Prod. 2005 Jul;68(7):1061-5. DMXOF4Z RU https://pubmed.ncbi.nlm.nih.gov/16038549 DMKTE5V DI DMKTE5V DMKTE5V DN N-octadecyl-N'-propylsulfamide DMKTE5V MI TT6OEDT DMKTE5V MN Cannabinoid receptor 1 (CB1) DMKTE5V MT DTT DMKTE5V MA Inhibitor DMKTE5V RN Synthesis and pharmacological evaluation of sulfamide-based analogues of anandamide. Eur J Med Chem. 2009 Dec;44(12):4889-95. DMKTE5V RU https://pubmed.ncbi.nlm.nih.gov/19762126 DM95JEW DI DM95JEW DM95JEW DN N-Octylcarbamic Acid Biphenyl-3-yl Ester DM95JEW MI TTDP1UC DM95JEW MN Fatty acid amide hydrolase (FAAH) DM95JEW MT DTT DM95JEW MA Inhibitor DM95JEW RN Synthesis and quantitative structure-activity relationship of fatty acid amide hydrolase inhibitors: modulation at the N-portion of biphenyl-3-yl a... J Med Chem. 2008 Jun 26;51(12):3487-98. DM95JEW RU https://pubmed.ncbi.nlm.nih.gov/18507372 DM50TCG DI DM50TCG DM50TCG DN Nogalamycin DM50TCG MI TTGTQHC DM50TCG MN DNA topoisomerase I (TOP1) DM50TCG MT DTT DM50TCG MA Intercalator DM50TCG RN Structure, dynamics and hydration of the nogalamycin-d(ATGCAT)2Complex determined by NMR and molecular dynamics simulations in solution. J Mol Biol. 1999 Jul 16;290(3):699-716. DM50TCG RU https://pubmed.ncbi.nlm.nih.gov/10395824 DM50TCG DI DM50TCG DM50TCG DN Nogalamycin DM50TCG MI DTUGYRD DM50TCG MN P-glycoprotein 1 (ABCB1) DM50TCG MT DTP DM50TCG MA Substrate DM50TCG RN Fingerprint-based in silico models for the prediction of P-glycoprotein substrates and inhibitors. Bioorg Med Chem. 2012 Sep 15;20(18):5388-95. DM50TCG RU https://doi.org/10.1016/j.bmc.2012.03.045 DMYZRTB DI DMYZRTB DMYZRTB DN Nojirimycine Tetrazole DMYZRTB MI TTZHY6R DMYZRTB MN Glycogen phosphorylase muscle form (GP) DMYZRTB MT DTT DMYZRTB MA Inhibitor DMYZRTB RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DMYZRTB RU https://pubmed.ncbi.nlm.nih.gov/10592235 DMYZRTB DI DMYZRTB DMYZRTB DN Nojirimycine Tetrazole DMYZRTB MI TTA0OSE DMYZRTB MN Lactase-phlorizin hydrolase (LCT) DMYZRTB MT DTT DMYZRTB MA Inhibitor DMYZRTB RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DMYZRTB RU https://pubmed.ncbi.nlm.nih.gov/10592235 DM1AVCZ DI DM1AVCZ DM1AVCZ DN N-oleoyl-dopamine DM1AVCZ MI TTIQSC1 DM1AVCZ MN Bacterial Lethal factor (Bact lef) DM1AVCZ MT DTT DM1AVCZ MA Inhibitor DM1AVCZ RN Inhibitors of anthrax lethal factor. Bioorg Med Chem Lett. 2007 Aug 15;17(16):4575-8. DM1AVCZ RU https://pubmed.ncbi.nlm.nih.gov/17574849 DMJQ4L7 DI DMJQ4L7 DMJQ4L7 DN N-oleoylethanolamide DMJQ4L7 MI TT6OEDT DMJQ4L7 MN Cannabinoid receptor 1 (CB1) DMJQ4L7 MT DTT DMJQ4L7 MA Inhibitor DMJQ4L7 RN Conformationally constrained fatty acid ethanolamides as cannabinoid and vanilloid receptor probes. J Med Chem. 2009 May 14;52(9):3001-9. DMJQ4L7 RU https://pubmed.ncbi.nlm.nih.gov/19361197 DMJQ4L7 DI DMJQ4L7 DMJQ4L7 DN N-oleoylethanolamide DMJQ4L7 MI TT7QNVC DMJQ4L7 MN Glucose-dependent insulinotropic receptor (GPR119) DMJQ4L7 MT DTT DMJQ4L7 MA Agonist DMJQ4L7 RN Screening beta-arrestin recruitment for the identification of natural ligands for orphan G-protein-coupled receptors. J Biomol Screen. 2013 Jun;18(5):599-609. DMJQ4L7 RU https://pubmed.ncbi.nlm.nih.gov/23396314 DMJQ4L7 DI DMJQ4L7 DMJQ4L7 DN N-oleoylethanolamide DMJQ4L7 MI TTNET8J DMJQ4L7 MN G-protein coupled receptor 55 (GPR55) DMJQ4L7 MT DTT DMJQ4L7 MA Agonist DMJQ4L7 RN The orphan receptor GPR55 is a novel cannabinoid receptor. Br J Pharmacol. 2007 Dec;152(7):1092-101. DMJQ4L7 RU https://pubmed.ncbi.nlm.nih.gov/17876302 DMJQ4L7 DI DMJQ4L7 DMJQ4L7 DN N-oleoylethanolamide DMJQ4L7 MI TTJ584C DMJQ4L7 MN Peroxisome proliferator-activated receptor alpha (PPARA) DMJQ4L7 MT DTT DMJQ4L7 MA Agonist DMJQ4L7 RN Oleoylethanolamide, an endogenous PPAR-alpha agonist, lowers body weight and hyperlipidemia in obese rats. Neuropharmacology. 2005 Jun;48(8):1147-53. DMJQ4L7 RU https://pubmed.ncbi.nlm.nih.gov/15910890 DMRU21X DI DMRU21X DMRU21X DN N-oleoyl-N-(2-hydroxyethyl)hydroxylamine DMRU21X MI TTMSFAW DMRU21X MN Cannabinoid receptor 2 (CB2) DMRU21X MT DTT DMRU21X MA Inhibitor DMRU21X RN Oxyhomologues of anandamide and related endolipids: chemoselective synthesis and biological activity. J Med Chem. 2006 Apr 6;49(7):2333-8. DMRU21X RU https://pubmed.ncbi.nlm.nih.gov/16570929 DMZM3CH DI DMZM3CH DMZM3CH DN N-oleoyl-O-(2-hydroxyethyl)hydroxylamine DMZM3CH MI TTMSFAW DMZM3CH MN Cannabinoid receptor 2 (CB2) DMZM3CH MT DTT DMZM3CH MA Inhibitor DMZM3CH RN Oxyhomologues of anandamide and related endolipids: chemoselective synthesis and biological activity. J Med Chem. 2006 Apr 6;49(7):2333-8. DMZM3CH RU https://pubmed.ncbi.nlm.nih.gov/16570929 DM0BPCT DI DM0BPCT DM0BPCT DN N-omega-allyl-L-arginine DM0BPCT MI TTZUFI5 DM0BPCT MN Nitric-oxide synthase brain (NOS1) DM0BPCT MT DTT DM0BPCT MA Inhibitor DM0BPCT RN Structure-activity relationship of novel and known inhibitors of human dimethylarginine dimethylaminohydrolase-1: alkenyl-amidines as new leads. Bioorg Med Chem. 2008 Dec 15;16(24):10205-9. DM0BPCT RU https://pubmed.ncbi.nlm.nih.gov/19013076 DM0BPCT DI DM0BPCT DM0BPCT DN N-omega-allyl-L-arginine DM0BPCT MI TTCM4B3 DM0BPCT MN Nitric-oxide synthase endothelial (NOS3) DM0BPCT MT DTT DM0BPCT MA Inhibitor DM0BPCT RN Structure-activity relationship of novel and known inhibitors of human dimethylarginine dimethylaminohydrolase-1: alkenyl-amidines as new leads. Bioorg Med Chem. 2008 Dec 15;16(24):10205-9. DM0BPCT RU https://pubmed.ncbi.nlm.nih.gov/19013076 DM0BPCT DI DM0BPCT DM0BPCT DN N-omega-allyl-L-arginine DM0BPCT MI TTF10I9 DM0BPCT MN Nitric-oxide synthase inducible (NOS2) DM0BPCT MT DTT DM0BPCT MA Inhibitor DM0BPCT RN Structure-activity relationship of novel and known inhibitors of human dimethylarginine dimethylaminohydrolase-1: alkenyl-amidines as new leads. Bioorg Med Chem. 2008 Dec 15;16(24):10205-9. DM0BPCT RU https://pubmed.ncbi.nlm.nih.gov/19013076 DMOXQ3N DI DMOXQ3N DMOXQ3N DN N-Omega-Hydroxy-L-Arginine DMOXQ3N MI TTZUFI5 DMOXQ3N MN Nitric-oxide synthase brain (NOS1) DMOXQ3N MT DTT DMOXQ3N MA Inhibitor DMOXQ3N RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMOXQ3N RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMOXQ3N DI DMOXQ3N DMOXQ3N DN N-Omega-Hydroxy-L-Arginine DMOXQ3N MI TTCM4B3 DMOXQ3N MN Nitric-oxide synthase endothelial (NOS3) DMOXQ3N MT DTT DMOXQ3N MA Inhibitor DMOXQ3N RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMOXQ3N RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMOXQ3N DI DMOXQ3N DMOXQ3N DN N-Omega-Hydroxy-L-Arginine DMOXQ3N MI TTF10I9 DMOXQ3N MN Nitric-oxide synthase inducible (NOS2) DMOXQ3N MT DTT DMOXQ3N MA Inhibitor DMOXQ3N RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMOXQ3N RU https://pubmed.ncbi.nlm.nih.gov/17139284 DM9X3B7 DI DM9X3B7 DM9X3B7 DN N-omega-propargyl-L-arginine DM9X3B7 MI TTZUFI5 DM9X3B7 MN Nitric-oxide synthase brain (NOS1) DM9X3B7 MT DTT DM9X3B7 MA Inhibitor DM9X3B7 RN Structure-activity relationship of novel and known inhibitors of human dimethylarginine dimethylaminohydrolase-1: alkenyl-amidines as new leads. Bioorg Med Chem. 2008 Dec 15;16(24):10205-9. DM9X3B7 RU https://pubmed.ncbi.nlm.nih.gov/19013076 DM9X3B7 DI DM9X3B7 DM9X3B7 DN N-omega-propargyl-L-arginine DM9X3B7 MI TTCM4B3 DM9X3B7 MN Nitric-oxide synthase endothelial (NOS3) DM9X3B7 MT DTT DM9X3B7 MA Inhibitor DM9X3B7 RN Structure-activity relationship of novel and known inhibitors of human dimethylarginine dimethylaminohydrolase-1: alkenyl-amidines as new leads. Bioorg Med Chem. 2008 Dec 15;16(24):10205-9. DM9X3B7 RU https://pubmed.ncbi.nlm.nih.gov/19013076 DM9X3B7 DI DM9X3B7 DM9X3B7 DN N-omega-propargyl-L-arginine DM9X3B7 MI TTF10I9 DM9X3B7 MN Nitric-oxide synthase inducible (NOS2) DM9X3B7 MT DTT DM9X3B7 MA Inhibitor DM9X3B7 RN Structure-activity relationship of novel and known inhibitors of human dimethylarginine dimethylaminohydrolase-1: alkenyl-amidines as new leads. Bioorg Med Chem. 2008 Dec 15;16(24):10205-9. DM9X3B7 RU https://pubmed.ncbi.nlm.nih.gov/19013076 DM4X0WY DI DM4X0WY DM4X0WY DN N-Omega-Propyl-L-Arginine DM4X0WY MI TTZUFI5 DM4X0WY MN Nitric-oxide synthase brain (NOS1) DM4X0WY MT DTT DM4X0WY MA Inhibitor DM4X0WY RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DM4X0WY RU https://pubmed.ncbi.nlm.nih.gov/17139284 DM4X0WY DI DM4X0WY DM4X0WY DN N-Omega-Propyl-L-Arginine DM4X0WY MI TTF10I9 DM4X0WY MN Nitric-oxide synthase inducible (NOS2) DM4X0WY MT DTT DM4X0WY MA Inhibitor DM4X0WY RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DM4X0WY RU https://pubmed.ncbi.nlm.nih.gov/17139284 DM951PF DI DM951PF DM951PF DN Nonanoic acid biphenyl-2-ylamide DM951PF MI TTK3C21 DM951PF MN Acetoacetyl-CoA thiolase (ACAT1) DM951PF MT DTT DM951PF MA Inhibitor DM951PF RN Biphenyl versus phenylpyridazine derivatives: the role of the heterocycle in a series of acyl-CoA:cholesterol acyl transferase inhibitors. J Med Chem. 2008 Mar 13;51(5):1474-7. DM951PF RU https://pubmed.ncbi.nlm.nih.gov/18284184 DMMJFTR DI DMMJFTR DMMJFTR DN Non-PEGylated butyrylcholinesterase DMMJFTR MI TTEB0GD DMMJFTR MN Cholinesterase (BCHE) DMMJFTR MT DTT DMMJFTR MA Modulator DMMJFTR RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2471). DMMJFTR RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2471 DMZ2DSK DI DMZ2DSK DMZ2DSK DN Non-peptide TPO mimics DMZ2DSK MI TTIHYA4 DMZ2DSK MN Thrombopoietin receptor (MPL) DMZ2DSK MT DTT DMZ2DSK MA Modulator DMZ2DSK RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1722). DMZ2DSK RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1722 DMFNB40 DI DMFNB40 DMFNB40 DN Noradrenalone (arterenone) DMFNB40 MI TTN451K DMFNB40 MN Aromatic-L-amino-acid decarboxylase (DDC) DMFNB40 MT DTT DMFNB40 MA Activator DMFNB40 RN Activation of an adrenergic pro-drug through sequential stereoselective action of tandem target enzymes. Biochem Biophys Res Commun. 1992 Nov 30;189(1):33-9. DMFNB40 RU https://pubmed.ncbi.nlm.nih.gov/1449487 DMZ9024 DI DMZ9024 DMZ9024 DN NORARISTEROMYCIN DMZ9024 MI TTE2KUJ DMZ9024 MN Adenosylhomocysteinase (AHCY) DMZ9024 MT DTT DMZ9024 MA Inhibitor DMZ9024 RN Synthesis of 4'-modified noraristeromycins to clarify the effect of the 4'-hydroxyl groups for inhibitory activity against S-adenosyl-L-homocystein... Bioorg Med Chem Lett. 2008 Apr 15;18(8):2615-8. DMZ9024 RU https://pubmed.ncbi.nlm.nih.gov/18374570 DMLYZOG DI DMLYZOG DMLYZOG DN NORBINALTORPHIMINE DMLYZOG MI TT27RFC DMLYZOG MN Opioid receptor delta (OPRD1) DMLYZOG MT DTT DMLYZOG MA Inhibitor DMLYZOG RN Identification of (3R)-7-hydroxy-N-((1S)-1-[[(3R,4R)-4-(3-hydroxyphenyl)- 3,4-dimethyl-1-piperidinyl]methyl]-2-methylpropyl)-1,2,3,4-tetrahydro- 3-... J Med Chem. 2003 Jul 3;46(14):3127-37. DMLYZOG RU https://pubmed.ncbi.nlm.nih.gov/12825951 DMLYZOG DI DMLYZOG DMLYZOG DN NORBINALTORPHIMINE DMLYZOG MI TTQW87Y DMLYZOG MN Opioid receptor kappa (OPRK1) DMLYZOG MT DTT DMLYZOG MA Inhibitor DMLYZOG RN Synthesis of pyrrolomorphinan derivatives as kappa opioid agonists. Bioorg Med Chem Lett. 2010 Sep 1;20(17):5035-8. DMLYZOG RU https://pubmed.ncbi.nlm.nih.gov/20685120 DMLYZOG DI DMLYZOG DMLYZOG DN NORBINALTORPHIMINE DMLYZOG MI TTKWM86 DMLYZOG MN Opioid receptor mu (MOP) DMLYZOG MT DTT DMLYZOG MA Inhibitor DMLYZOG RN Synthesis of pyrrolomorphinan derivatives as kappa opioid agonists. Bioorg Med Chem Lett. 2010 Sep 1;20(17):5035-8. DMLYZOG RU https://pubmed.ncbi.nlm.nih.gov/20685120 DM6HKEC DI DM6HKEC DM6HKEC DN Nor-binaltorphimine dihydrochloride DM6HKEC MI TTQW87Y DM6HKEC MN Opioid receptor kappa (OPRK1) DM6HKEC MT DTT DM6HKEC MA Antagonist DM6HKEC RN Kappa-opioid receptor selectivity for ischemic neuroprotection with BRL 52537 in rats. Anesth Analg. 2003 Dec;97(6):1776-83. DM6HKEC RU https://pubmed.ncbi.nlm.nih.gov/14633559 DM6BNQR DI DM6BNQR DM6BNQR DN NORBOLDINE DM6BNQR MI TTVBI8W DM6BNQR MN Dopamine transporter (DAT) DM6BNQR MT DTT DM6BNQR MA Inhibitor DM6BNQR RN Effects of various isoquinoline alkaloids on in vitro 3H-dopamine uptake by rat striatal synaptosomes. J Nat Prod. 1995 Oct;58(10):1475-84. DM6BNQR RU https://pubmed.ncbi.nlm.nih.gov/8676127 DM9B6Y1 DI DM9B6Y1 DM9B6Y1 DN NORCANTHARIDIN DM9B6Y1 MI TTLONKX DM9B6Y1 MN PP2A B subunit isoform R5-alpha (PPP2R5A) DM9B6Y1 MT DTT DM9B6Y1 MA Inhibitor DM9B6Y1 RN Structure-activity relationship of cantharidin derivatives to protein phosphatases 1, 2A1, and 2B, Bioorg. Med. Chem. Lett. 7(14):1833-1836 (1997). DM9B6Y1 RU http://www.sciencedirect.com/science/article/pii/S0960894X97003168 DM9B6Y1 DI DM9B6Y1 DM9B6Y1 DN NORCANTHARIDIN DM9B6Y1 MI TTFLH0E DM9B6Y1 MN Serine/threonine PP1-alpha (PPP1CA) DM9B6Y1 MT DTT DM9B6Y1 MA Inhibitor DM9B6Y1 RN In silico identification and biochemical evaluation of novel inhibitors of NRH:quinone oxidoreductase 2 (NQO2). Bioorg Med Chem Lett. 2010 Dec 15;20(24):7331-6. DM9B6Y1 RU https://pubmed.ncbi.nlm.nih.gov/21074425 DMHAWYQ DI DMHAWYQ DMHAWYQ DN Nordazepam DMHAWYQ MI DE4LYSA DMHAWYQ MN Cytochrome P450 3A4 (CYP3A4) DMHAWYQ MT DME DMHAWYQ MA Metabolism DMHAWYQ RN Sigmoidal kinetic model for two co-operative substrate-binding sites in a cytochrome P450 3A4 active site: an example of the metabolism of diazepam and its derivatives. Biochem J. 1999 Jun 15;340 ( Pt 3):845-53. DMHAWYQ RU https://www.ncbi.nlm.nih.gov/pubmed/?term=10359672 DMHAWYQ DI DMHAWYQ DMHAWYQ DN Nordazepam DMHAWYQ MI DEGTFWK DMHAWYQ MN Mephenytoin 4-hydroxylase (CYP2C19) DMHAWYQ MT DME DMHAWYQ MA Metabolism DMHAWYQ RN Effect of the gene dosage of CgammaP2C19 on diazepam metabolism in Chinese subjects. Clin Pharmacol Ther. 1999 Dec;66(6):642-6. DMHAWYQ RU https://www.ncbi.nlm.nih.gov/pubmed/?term=10613621 DMGI4ZW DI DMGI4ZW DMGI4ZW DN norfenfluramine DMGI4ZW MI TT0K1SC DMGI4ZW MN 5-HT 2B receptor (HTR2B) DMGI4ZW MT DTT DMGI4ZW MA Agonist DMGI4ZW RN Evidence for possible involvement of 5-HT(2B) receptors in the cardiac valvulopathy associated with fenfluramine and other serotonergic medications. Circulation. 2000 Dec 5;102(23):2836-41. DMGI4ZW RU https://pubmed.ncbi.nlm.nih.gov/11104741 DMKNUP3 DI DMKNUP3 DMKNUP3 DN norfluoxetine DMKNUP3 MI TTJQOD7 DMKNUP3 MN 5-HT 2A receptor (HTR2A) DMKNUP3 MT DTT DMKNUP3 MA Antagonist DMKNUP3 RN Evidence for possible involvement of 5-HT(2B) receptors in the cardiac valvulopathy associated with fenfluramine and other serotonergic medications. Circulation. 2000 Dec 5;102(23):2836-41. DMKNUP3 RU https://pubmed.ncbi.nlm.nih.gov/11104741 DMKNUP3 DI DMKNUP3 DMKNUP3 DN norfluoxetine DMKNUP3 MI TT0K1SC DMKNUP3 MN 5-HT 2B receptor (HTR2B) DMKNUP3 MT DTT DMKNUP3 MA Antagonist DMKNUP3 RN Evidence for possible involvement of 5-HT(2B) receptors in the cardiac valvulopathy associated with fenfluramine and other serotonergic medications. Circulation. 2000 Dec 5;102(23):2836-41. DMKNUP3 RU https://pubmed.ncbi.nlm.nih.gov/11104741 DMKNUP3 DI DMKNUP3 DMKNUP3 DN norfluoxetine DMKNUP3 MI TTWJBZ5 DMKNUP3 MN 5-HT 2C receptor (HTR2C) DMKNUP3 MT DTT DMKNUP3 MA Antagonist DMKNUP3 RN Evidence for possible involvement of 5-HT(2B) receptors in the cardiac valvulopathy associated with fenfluramine and other serotonergic medications. Circulation. 2000 Dec 5;102(23):2836-41. DMKNUP3 RU https://pubmed.ncbi.nlm.nih.gov/11104741 DMKNUP3 DI DMKNUP3 DMKNUP3 DN norfluoxetine DMKNUP3 MI TTVUWHQ DMKNUP3 MN Voltage-gated potassium channel Kv3.1 (KCNC1) DMKNUP3 MT DTT DMKNUP3 MA Inhibitor (gating inhibitor) DMKNUP3 RN Effects of norfluoxetine, the major metabolite of fluoxetine, on the cloned neuronal potassium channel Kv3.1. Neuropharmacology. 2001 Sep;41(4):443-53. DMKNUP3 RU https://pubmed.ncbi.nlm.nih.gov/11543764 DMKYQWG DI DMKYQWG DMKYQWG DN NORHARMANE DMKYQWG MI TT1MPAY DMKYQWG MN GABA(A) receptor alpha-1 (GABRA1) DMKYQWG MT DTT DMKYQWG MA Inhibitor DMKYQWG RN Synthesis of novel 3-substituted beta-carbolines as benzodiazepine receptor ligands: probing the benzodiazepine receptor pharmacophore. J Med Chem. 1988 Sep;31(9):1854-61. DMKYQWG RU https://pubmed.ncbi.nlm.nih.gov/2842507 DMKYQWG DI DMKYQWG DMKYQWG DN NORHARMANE DMKYQWG MI TTNJYV2 DMKYQWG MN Gamma-aminobutyric acid receptor (GAR) DMKYQWG MT DTT DMKYQWG MA Inhibitor DMKYQWG RN Synthesis of novel 3-substituted beta-carbolines as benzodiazepine receptor ligands: probing the benzodiazepine receptor pharmacophore. J Med Chem. 1988 Sep;31(9):1854-61. DMKYQWG RU https://pubmed.ncbi.nlm.nih.gov/2842507 DMYQGFJ DI DMYQGFJ DMYQGFJ DN normorphine DMYQGFJ MI TT27RFC DMYQGFJ MN Opioid receptor delta (OPRD1) DMYQGFJ MT DTT DMYQGFJ MA Agonist DMYQGFJ RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 317). DMYQGFJ RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=317 DMYQGFJ DI DMYQGFJ DMYQGFJ DN normorphine DMYQGFJ MI TTQW87Y DMYQGFJ MN Opioid receptor kappa (OPRK1) DMYQGFJ MT DTT DMYQGFJ MA Agonist DMYQGFJ RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 318). DMYQGFJ RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=318 DMYQGFJ DI DMYQGFJ DMYQGFJ DN normorphine DMYQGFJ MI TTKWM86 DMYQGFJ MN Opioid receptor mu (MOP) DMYQGFJ MT DTT DMYQGFJ MA Agonist DMYQGFJ RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 319). DMYQGFJ RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=319 DMSZWGN DI DMSZWGN DMSZWGN DN NOR-ROEFRACTINE DMSZWGN MI TTEX248 DMSZWGN MN Dopamine D2 receptor (D2R) DMSZWGN MT DTT DMSZWGN MA Inhibitor DMSZWGN RN Synthesis and dopamine receptor selectivity of the benzyltetrahydroisoquinoline, (R)-(+)-nor-roefractine. J Nat Prod. 1998 Jun 26;61(6):709-12. DMSZWGN RU https://pubmed.ncbi.nlm.nih.gov/9644051 DM1VIHC DI DM1VIHC DM1VIHC DN NORSTEPHALAGINE DM1VIHC MI TTZFYLI DM1VIHC MN Dopamine D1 receptor (D1R) DM1VIHC MT DTT DM1VIHC MA Inhibitor DM1VIHC RN Advances in development of dopaminergic aporphinoids. J Med Chem. 2007 Jan 25;50(2):171-81. DM1VIHC RU https://pubmed.ncbi.nlm.nih.gov/17228858 DM1VIHC DI DM1VIHC DM1VIHC DN NORSTEPHALAGINE DM1VIHC MI TTVBI8W DM1VIHC MN Dopamine transporter (DAT) DM1VIHC MT DTT DM1VIHC MA Inhibitor DM1VIHC RN Effects of various isoquinoline alkaloids on in vitro 3H-dopamine uptake by rat striatal synaptosomes. J Nat Prod. 1995 Oct;58(10):1475-84. DM1VIHC RU https://pubmed.ncbi.nlm.nih.gov/8676127 DMTY43L DI DMTY43L DMTY43L DN Nortropinyl-arylsulfonylurea 3 DMTY43L MI TTHM0R1 DMTY43L MN Steryl-sulfatase (STS) DMTY43L MT DTT DMTY43L MA Inhibitor DMTY43L RN Nortropinyl-arylsulfonylureas as novel, reversible inhibitors of human steroid sulfatase. Bioorg Med Chem Lett. 2003 Nov 3;13(21):3673-7. DMTY43L RU https://pubmed.ncbi.nlm.nih.gov/14552755 DM19FS3 DI DM19FS3 DM19FS3 DN Norzimelidine DM19FS3 MI TTJXYQ6 DM19FS3 MN Monoamine uptake (MA uptake) DM19FS3 MT DTT DM19FS3 MA Inhibitor DM19FS3 RN The antidepressant agents desipramine, fluoxetine, fluvoxamine and norzimelidine inhibit uptake of [3H]noradrenaline and [3H]5-hydroxytryptamine in slices of human and rat cortical brain tissue. Brain Res. 1983 Sep 19;275(1):99-104. DM19FS3 RU https://pubmed.ncbi.nlm.nih.gov/6226337 DMS3N4X DI DMS3N4X DMS3N4X DN norzotepine DMS3N4X MI TTAWNKZ DMS3N4X MN Norepinephrine transporter (NET) DMS3N4X MT DTT DMS3N4X MA Inhibitor DMS3N4X RN Norzotepine, a major metabolite of zotepine, exerts atypical antipsychotic-like and antidepressant-like actions through its potent inhibition of norepinephrine reuptake. J Pharmacol Exp Ther. 2010 Jun;333(3):772-81. DMS3N4X RU https://pubmed.ncbi.nlm.nih.gov/20223878 DMS3N4X DI DMS3N4X DMS3N4X DN norzotepine DMS3N4X MI TT3ROYC DMS3N4X MN Serotonin transporter (SERT) DMS3N4X MT DTT DMS3N4X MA Inhibitor DMS3N4X RN Norzotepine, a major metabolite of zotepine, exerts atypical antipsychotic-like and antidepressant-like actions through its potent inhibition of norepinephrine reuptake. J Pharmacol Exp Ther. 2010 Jun;333(3):772-81. DMS3N4X RU https://pubmed.ncbi.nlm.nih.gov/20223878 DME5O17 DI DME5O17 DME5O17 DN NOSTOCARBOLINE DME5O17 MI TTEB0GD DME5O17 MN Cholinesterase (BCHE) DME5O17 MT DTT DME5O17 MA Inhibitor DME5O17 RN Nostocarboline: isolation and synthesis of a new cholinesterase inhibitor from Nostoc 78-12A. J Nat Prod. 2005 Dec;68(12):1793-5. DME5O17 RU https://pubmed.ncbi.nlm.nih.gov/16378379 DMLVFUY DI DMLVFUY DMLVFUY DN N-o-Tolyl-1'H-phenothiazine-1'-carboxamide DMLVFUY MI TTEB0GD DMLVFUY MN Cholinesterase (BCHE) DMLVFUY MT DTT DMLVFUY MA Inhibitor DMLVFUY RN Differential binding of phenothiazine urea derivatives to wild-type human cholinesterases and butyrylcholinesterase mutants. Bioorg Med Chem. 2010 Mar 15;18(6):2232-2244. DMLVFUY RU https://pubmed.ncbi.nlm.nih.gov/20181484 DM82DNL DI DM82DNL DM82DNL DN Nova-EPO DM82DNL MI TTAUX24 DM82DNL MN Erythropoietin Receptor (EPOR) DM82DNL MT DTT DM82DNL MA Modulator DM82DNL RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1718). DM82DNL RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1718 DM3C2VA DI DM3C2VA DM3C2VA DN Novo Nordisk a/S Compound DM3C2VA MI TTELIN2 DM3C2VA MN PTPN1 messenger RNA (PTPN1 mRNA) DM3C2VA MT DTT DM3C2VA MA Inhibitor DM3C2VA RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DM3C2VA RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMAM5ZO DI DMAM5ZO DMAM5ZO DN NOX 2137a/b DMAM5ZO MI TTNT7K8 DMAM5ZO MN Nociceptin receptor (OPRL1) DMAM5ZO MT DTT DMAM5ZO RN Therapeutic applications of aptamers. Expert Opin Investig Drugs. 2008 Jan;17(1):43-60. DMAM5ZO RU https://pubmed.ncbi.nlm.nih.gov/18095918 DMZVDLS DI DMZVDLS DMZVDLS DN NOX 2149 DMZVDLS MI TTNT7K8 DMZVDLS MN Nociceptin receptor (OPRL1) DMZVDLS MT DTT DMZVDLS RN Therapeutic applications of aptamers. Expert Opin Investig Drugs. 2008 Jan;17(1):43-60. DMZVDLS RU https://pubmed.ncbi.nlm.nih.gov/18095918 DMFW8O5 DI DMFW8O5 DMFW8O5 DN NOX-B11 DMFW8O5 MI TTWDC17 DMFW8O5 MN Growth hormone secretagogue receptor 1 (GHSR) DMFW8O5 MT DTT DMFW8O5 MA Antagonist DMFW8O5 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 246). DMFW8O5 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=246 DMQ84J7 DI DMQ84J7 DMQ84J7 DN N-oxo-2-(phenylsulfonylamino)ethanamide DMQ84J7 MI TTXZ0KQ DMQ84J7 MN Matrix metalloproteinase-12 (MMP-12) DMQ84J7 MT DTT DMQ84J7 MA Inhibitor DMQ84J7 RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DMQ84J7 RU https://pubmed.ncbi.nlm.nih.gov/10592235 DMHTI5X DI DMHTI5X DMHTI5X DN N-oxo-2-[(4-phenylphenyl)sulfonylamino]ethanamide DMHTI5X MI TTXZ0KQ DMHTI5X MN Matrix metalloproteinase-12 (MMP-12) DMHTI5X MT DTT DMHTI5X MA Inhibitor DMHTI5X RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DMHTI5X RU https://pubmed.ncbi.nlm.nih.gov/10592235 DMVS6DW DI DMVS6DW DMVS6DW DN NOX-S91 DMVS6DW MI TT9JZCK DMVS6DW MN Sphingosine-1-phosphate receptor 1 (S1PR1) DMVS6DW MT DTT DMVS6DW MA Inhibitor DMVS6DW RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 275). DMVS6DW RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=275 DM906YB DI DM906YB DM906YB DN NP-0336 DM906YB MI TTEB0GD DM906YB MN Cholinesterase (BCHE) DM906YB MT DTT DM906YB MA Inhibitor DM906YB RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2471). DM906YB RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2471 DM51S0B DI DM51S0B DM51S0B DN NP16 DM51S0B MI TTR5YAZ DM51S0B MN Staphylococcus Dehydrosqualene desaturase (Stap-coc crtN) DM51S0B MT DTT DM51S0B MA Inhibitor DM51S0B RN Dehydrosqualene Desaturase as a Novel Target for Anti-Virulence Therapy against Staphylococcus aureus.MBio. 2017 Sep 5;8(5). pii: e01224-17. DM51S0B RU https://pubmed.ncbi.nlm.nih.gov/28874472 DMVPIF8 DI DMVPIF8 DMVPIF8 DN NP-506 DMVPIF8 MI TTRLW2X DMVPIF8 MN Fibroblast growth factor receptor 1 (FGFR1) DMVPIF8 MT DTT DMVPIF8 MA Inhibitor DMVPIF8 RN 5-Substituted pyrido[2,3-d]pyrimidine, an inhibitor against three receptor tyrosine kinases. Bioorg Med Chem Lett. 2009 Feb 1;19(3):745-50. DMVPIF8 RU https://pubmed.ncbi.nlm.nih.gov/19110422 DMMZXRT DI DMMZXRT DMMZXRT DN NP93-31 DMMZXRT MI TTN9D8E DMMZXRT MN Glutamate receptor ionotropic NMDA 2B (NMDAR2B) DMMZXRT MT DTT DMMZXRT MA Antagonist DMMZXRT RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 457). DMMZXRT RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=457 DMU426Z DI DMU426Z DMU426Z DN NPC-349 DMU426Z MI TTGY8IW DMU426Z MN B2 bradykinin receptor (BDKRB2) DMU426Z MT DTT DMU426Z MA Antagonist DMU426Z RN Differential pharmacology of cloned human and mouse B2 bradykinin receptors. Mol Pharmacol. 1994 Jan;45(1):1-8. DMU426Z RU https://pubmed.ncbi.nlm.nih.gov/8302267 DMJQZMH DI DMJQZMH DMJQZMH DN N-phenethyl-2-(pyrrolidin-1-yl)pyrimidin-4-amine DMJQZMH MI TT1RS9F DMJQZMH MN Acetylcholinesterase (AChE) DMJQZMH MT DTT DMJQZMH MA Inhibitor DMJQZMH RN Design, synthesis and evaluation of 2,4-disubstituted pyrimidines as cholinesterase inhibitors. Bioorg Med Chem Lett. 2010 Jun 15;20(12):3606-9. DMJQZMH RU https://pubmed.ncbi.nlm.nih.gov/20472431 DMJQZMH DI DMJQZMH DMJQZMH DN N-phenethyl-2-(pyrrolidin-1-yl)pyrimidin-4-amine DMJQZMH MI TTEB0GD DMJQZMH MN Cholinesterase (BCHE) DMJQZMH MT DTT DMJQZMH MA Inhibitor DMJQZMH RN Design, synthesis and evaluation of 2,4-disubstituted pyrimidines as cholinesterase inhibitors. Bioorg Med Chem Lett. 2010 Jun 15;20(12):3606-9. DMJQZMH RU https://pubmed.ncbi.nlm.nih.gov/20472431 DM1BU5P DI DM1BU5P DM1BU5P DN N-Phenethyl-2-(toluene-4-sulfonylamino)-benzamide DM1BU5P MI TTW0CMT DM1BU5P MN Voltage-gated potassium channel Kv1.5 (KCNA5) DM1BU5P MT DTT DM1BU5P MA Inhibitor DM1BU5P RN Pharmacophore-based search, synthesis, and biological evaluation of anthranilic amides as novel blockers of the Kv1.5 channel. Bioorg Med Chem Lett. 2004 Jun 7;14(11):2823-7. DM1BU5P RU https://pubmed.ncbi.nlm.nih.gov/15125940 DM4G6LJ DI DM4G6LJ DM4G6LJ DN N-phenethyl-2-phenylquinoline-4-carboxamide DM4G6LJ MI TTBPGLU DM4G6LJ MN Neuromedin-K receptor (TACR3) DM4G6LJ MT DTT DM4G6LJ MA Inhibitor DM4G6LJ RN Virtual screening to identify novel antagonists for the G protein-coupled NK3 receptor. J Med Chem. 2010 Nov 25;53(22):8080-8. DM4G6LJ RU https://pubmed.ncbi.nlm.nih.gov/21047106 DM1ZPGY DI DM1ZPGY DM1ZPGY DN N-phenethylquinoxaline-2-carboxamide DM1ZPGY MI TTVBPDM DM1ZPGY MN Metabotropic glutamate receptor 1 (mGluR1) DM1ZPGY MT DTT DM1ZPGY MA Inhibitor DM1ZPGY RN Structure-activity relationships of novel non-competitive mGluR1 antagonists: a potential treatment for chronic pain. Bioorg Med Chem Lett. 2007 Jan 15;17(2):486-90. DM1ZPGY RU https://pubmed.ncbi.nlm.nih.gov/17064898 DM7V025 DI DM7V025 DM7V025 DN N-Phenyl-1H-indole-2-carboxamide DM7V025 MI TT3WG5C DM7V025 MN Monoamine oxidase type A (MAO-A) DM7V025 MT DTT DM7V025 MA Inhibitor DM7V025 RN Synthesis, structure-activity relationships and molecular modeling studies of new indole inhibitors of monoamine oxidases A and B. Bioorg Med Chem. 2008 Nov 15;16(22):9729-40. DM7V025 RU https://pubmed.ncbi.nlm.nih.gov/18951803 DM7V025 DI DM7V025 DM7V025 DN N-Phenyl-1H-indole-2-carboxamide DM7V025 MI TTGP7BY DM7V025 MN Monoamine oxidase type B (MAO-B) DM7V025 MT DTT DM7V025 MA Inhibitor DM7V025 RN Synthesis, structure-activity relationships and molecular modeling studies of new indole inhibitors of monoamine oxidases A and B. Bioorg Med Chem. 2008 Nov 15;16(22):9729-40. DM7V025 RU https://pubmed.ncbi.nlm.nih.gov/18951803 DM1LHD3 DI DM1LHD3 DM1LHD3 DN N-Phenyl-1'H-phenothiazine-1'-carboxamide DM1LHD3 MI TTEB0GD DM1LHD3 MN Cholinesterase (BCHE) DM1LHD3 MT DTT DM1LHD3 MA Inhibitor DM1LHD3 RN Differential binding of phenothiazine urea derivatives to wild-type human cholinesterases and butyrylcholinesterase mutants. Bioorg Med Chem. 2010 Mar 15;18(6):2232-2244. DM1LHD3 RU https://pubmed.ncbi.nlm.nih.gov/20181484 DMP5E1G DI DMP5E1G DMP5E1G DN N-phenyl-1H-pyrazole-3-carboxamide DMP5E1G MI TT7HF4W DMP5E1G MN Cyclin-dependent kinase 2 (CDK2) DMP5E1G MT DTT DMP5E1G MA Inhibitor DMP5E1G RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DMP5E1G RU https://pubmed.ncbi.nlm.nih.gov/10592235 DMBGIUE DI DMBGIUE DMBGIUE DN N-phenyl-1H-pyrrole-2-carboxamide DMBGIUE MI TT3WG5C DMBGIUE MN Monoamine oxidase type A (MAO-A) DMBGIUE MT DTT DMBGIUE MA Inhibitor DMBGIUE RN New pyrrole inhibitors of monoamine oxidase: synthesis, biological evaluation, and structural determinants of MAO-A and MAO-B selectivity. J Med Chem. 2007 Mar 8;50(5):922-31. DMBGIUE RU https://pubmed.ncbi.nlm.nih.gov/17256833 DM1XV0O DI DM1XV0O DM1XV0O DN N-Phenyl-1-methyl-1H-indole-2-carboxamide DM1XV0O MI TT3WG5C DM1XV0O MN Monoamine oxidase type A (MAO-A) DM1XV0O MT DTT DM1XV0O MA Inhibitor DM1XV0O RN Synthesis, structure-activity relationships and molecular modeling studies of new indole inhibitors of monoamine oxidases A and B. Bioorg Med Chem. 2008 Nov 15;16(22):9729-40. DM1XV0O RU https://pubmed.ncbi.nlm.nih.gov/18951803 DM0JI2L DI DM0JI2L DM0JI2L DN N-phenyl-2,3,4-trihydroxy-5-benzyl-benzamide DM0JI2L MI TTJGNVC DM0JI2L MN Apoptosis regulator Bcl-2 (BCL-2) DM0JI2L MT DTT DM0JI2L MA Inhibitor DM0JI2L RN Structure-based design of potent small-molecule inhibitors of anti-apoptotic Bcl-2 proteins. J Med Chem. 2006 Oct 19;49(21):6139-42. DM0JI2L RU https://pubmed.ncbi.nlm.nih.gov/17034116 DMWH86J DI DMWH86J DMWH86J DN N-phenyl-3-(2-aminoethyl)benzenesulfonamide DMWH86J MI TTJS8PY DMWH86J MN 5-HT 6 receptor (HTR6) DMWH86J MT DTT DMWH86J MA Inhibitor DMWH86J RN Binding of sulfonyl-containing arylalkylamines at human 5-HT6 serotonin receptors. J Med Chem. 2006 Aug 24;49(17):5217-25. DMWH86J RU https://pubmed.ncbi.nlm.nih.gov/16913710 DM7XER1 DI DM7XER1 DM7XER1 DN N-phenyl-5,6-dip-tolylpyrazine-2-carboxamide DM7XER1 MI TT6OEDT DM7XER1 MN Cannabinoid receptor 1 (CB1) DM7XER1 MT DTT DM7XER1 MA Inhibitor DM7XER1 RN Discovery of pyrazine carboxamide CB1 antagonists: the introduction of a hydroxyl group improves the pharmaceutical properties and in vivo efficacy... Bioorg Med Chem Lett. 2007 Jul 15;17(14):3978-82. DM7XER1 RU https://pubmed.ncbi.nlm.nih.gov/17513109 DMGVJBD DI DMGVJBD DMGVJBD DN N-Phenyl-5-phenylimidazo[1,5-a]pyrazin-8-amine DMGVJBD MI TT6PKBN DMGVJBD MN Proto-oncogene c-Src (SRC) DMGVJBD MT DTT DMGVJBD MA Inhibitor DMGVJBD RN Synthesis and c-Src inhibitory activity of imidazo[1,5-a]pyrazine derivatives as an agent for treatment of acute ischemic stroke. Bioorg Med Chem. 2007 Jan 15;15(2):868-85. DMGVJBD RU https://pubmed.ncbi.nlm.nih.gov/17095233 DMRHKF8 DI DMRHKF8 DMRHKF8 DN N-phenyl-6-(sulfamoylamino)hexanamide DMRHKF8 MI TT5ZKDI DMRHKF8 MN Histone deacetylase 6 (HDAC6) DMRHKF8 MT DTT DMRHKF8 MA Inhibitor DMRHKF8 RN Sulfamides as novel histone deacetylase inhibitors. Bioorg Med Chem Lett. 2009 Jan 15;19(2):336-40. DMRHKF8 RU https://pubmed.ncbi.nlm.nih.gov/19084395 DMXANES DI DMXANES DMXANES DN N-Phenylbenzo[d]oxazol-2-amine DMXANES MI TT2J34L DMXANES MN Arachidonate 5-lipoxygenase (5-LOX) DMXANES MT DTT DMXANES MA Inhibitor DMXANES RN Synthesis and evaluation of benzoxazole derivatives as 5-lipoxygenase inhibitors. Bioorg Med Chem. 2010 Nov 1;18(21):7580-5. DMXANES RU https://pubmed.ncbi.nlm.nih.gov/20870413 DM1VSO9 DI DM1VSO9 DM1VSO9 DN N-Phenylethyl-ETAV DM1VSO9 MI TT9PB26 DM1VSO9 MN Presynaptic density protein 95 (DLG4) DM1VSO9 MT DTT DM1VSO9 MA Inhibitor DM1VSO9 RN Modified peptides as potent inhibitors of the postsynaptic density-95/N-methyl-D-aspartate receptor interaction. J Med Chem. 2008 Oct 23;51(20):6450-9. DM1VSO9 RU https://pubmed.ncbi.nlm.nih.gov/18811137 DM90GNC DI DM90GNC DM90GNC DN N-Phenylpropyl-ETAV DM90GNC MI TT9PB26 DM90GNC MN Presynaptic density protein 95 (DLG4) DM90GNC MT DTT DM90GNC MA Inhibitor DM90GNC RN Modified peptides as potent inhibitors of the postsynaptic density-95/N-methyl-D-aspartate receptor interaction. J Med Chem. 2008 Oct 23;51(20):6450-9. DM90GNC RU https://pubmed.ncbi.nlm.nih.gov/18811137 DMFIWAN DI DMFIWAN DMFIWAN DN NPPB DMFIWAN MI TTOJI4S DMFIWAN MN Calcium-dependent chloride channel anoctamin (ANO) DMFIWAN MT DTT DMFIWAN MA Blocker (channel blocker) DMFIWAN RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 708). DMFIWAN RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=708 DMFIWAN DI DMFIWAN DMFIWAN DN NPPB DMFIWAN MI TT30NW6 DMFIWAN MN Chloride channel protein 2 (CLC-2) DMFIWAN MT DTT DMFIWAN MA Blocker (channel blocker) DMFIWAN RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 699). DMFIWAN RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=699 DMFIWAN DI DMFIWAN DMFIWAN DN NPPB DMFIWAN MI TTST1AJ DMFIWAN MN Chloride channel protein 7 (ClC-7) DMFIWAN MT DTT DMFIWAN MA Blocker (channel blocker) DMFIWAN RN The G215R mutation in the Cl-/H+-antiporter ClC-7 found in ADO II osteopetrosis does not abolish function but causes a severe trafficking defect. PLoS One. 2010 Sep 7;5(9):e12585. DMFIWAN RU https://pubmed.ncbi.nlm.nih.gov/20830208 DMFIWAN DI DMFIWAN DMFIWAN DN NPPB DMFIWAN MI TTT1MCF DMFIWAN MN Permeability pathway (NP pathway) DMFIWAN MT DTT DMFIWAN MA Inhibitor DMFIWAN RN Novel molecular targets for antimalarial drug development. Chem Biol Drug Des. 2008 Apr;71(4):287-97. DMFIWAN RU https://pubmed.ncbi.nlm.nih.gov/18298458 DMFIWAN DI DMFIWAN DMFIWAN DN NPPB DMFIWAN MI TTELV3W DMFIWAN MN Transformation-sensitive protein p120 (TRPA1) DMFIWAN MT DTT DMFIWAN MA Activator DMFIWAN RN NPPB structure-specifically activates TRPA1 channels. Biochem Pharmacol. 2010 Jul 1;80(1):113-21. DMFIWAN RU https://pubmed.ncbi.nlm.nih.gov/20226176 DMFIWAN DI DMFIWAN DMFIWAN DN NPPB DMFIWAN MI TT0FC1V DMFIWAN MN Volume regulated chloride channel (VRAC) DMFIWAN MT DTT DMFIWAN MA Blocker (channel blocker) DMFIWAN RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 710). DMFIWAN RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=710 DMHZCLV DI DMHZCLV DMHZCLV DN N-Propargyl-1(S)-Aminoindan DMHZCLV MI TTGP7BY DMHZCLV MN Monoamine oxidase type B (MAO-B) DMHZCLV MT DTT DMHZCLV MA Inhibitor DMHZCLV RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DMHZCLV RU https://pubmed.ncbi.nlm.nih.gov/10592235 DMNYQ28 DI DMNYQ28 DMNYQ28 DN N-propargyl-1H-pyrrole-2-carboxamide DMNYQ28 MI TT3WG5C DMNYQ28 MN Monoamine oxidase type A (MAO-A) DMNYQ28 MT DTT DMNYQ28 MA Inhibitor DMNYQ28 RN New pyrrole inhibitors of monoamine oxidase: synthesis, biological evaluation, and structural determinants of MAO-A and MAO-B selectivity. J Med Chem. 2007 Mar 8;50(5):922-31. DMNYQ28 RU https://pubmed.ncbi.nlm.nih.gov/17256833 DMKBG1F DI DMKBG1F DMKBG1F DN N-Propyl-2-methylnorapomorphine hydrochloride DMKBG1F MI TTEX248 DMKBG1F MN Dopamine D2 receptor (D2R) DMKBG1F MT DTT DMKBG1F MA Inhibitor DMKBG1F RN N-Substituted-2-alkyl- and 2-arylnorapomorphines: novel, highly active D2 agonists. Bioorg Med Chem. 2009 Jul 1;17(13):4756-62. DMKBG1F RU https://pubmed.ncbi.nlm.nih.gov/19454369 DML6SAG DI DML6SAG DML6SAG DN N-Propyl-2-phenylnorapomorphine hydrochloride DML6SAG MI TTEX248 DML6SAG MN Dopamine D2 receptor (D2R) DML6SAG MT DTT DML6SAG MA Inhibitor DML6SAG RN N-Substituted-2-alkyl- and 2-arylnorapomorphines: novel, highly active D2 agonists. Bioorg Med Chem. 2009 Jul 1;17(13):4756-62. DML6SAG RU https://pubmed.ncbi.nlm.nih.gov/19454369 DMUTDNV DI DMUTDNV DMUTDNV DN N-Propyl-ETAV DMUTDNV MI TT9PB26 DMUTDNV MN Presynaptic density protein 95 (DLG4) DMUTDNV MT DTT DMUTDNV MA Inhibitor DMUTDNV RN Modified peptides as potent inhibitors of the postsynaptic density-95/N-methyl-D-aspartate receptor interaction. J Med Chem. 2008 Oct 23;51(20):6450-9. DMUTDNV RU https://pubmed.ncbi.nlm.nih.gov/18811137 DMO7MTX DI DMO7MTX DMO7MTX DN N-propylnorapomorphine DMO7MTX MI TTZFYLI DMO7MTX MN Dopamine D1 receptor (D1R) DMO7MTX MT DTT DMO7MTX MA Agonist DMO7MTX RN Cloning of the gene for a human dopamine D5 receptor with higher affinity for dopamine than D1. Nature. 1991 Apr 18;350(6319):614-9. DMO7MTX RU https://pubmed.ncbi.nlm.nih.gov/1826762 DMO7MTX DI DMO7MTX DMO7MTX DN N-propylnorapomorphine DMO7MTX MI TTEX248 DMO7MTX MN Dopamine D2 receptor (D2R) DMO7MTX MT DTT DMO7MTX MA Inhibitor DMO7MTX RN A functional test identifies dopamine agonists selective for D3 versus D2 receptors. Neuroreport. 1995 Jan 26;6(2):329-32. DMO7MTX RU https://pubmed.ncbi.nlm.nih.gov/7756621 DMO7MTX DI DMO7MTX DMO7MTX DN N-propylnorapomorphine DMO7MTX MI TT4C8EA DMO7MTX MN Dopamine D3 receptor (D3R) DMO7MTX MT DTT DMO7MTX MA Agonist DMO7MTX RN A functional test identifies dopamine agonists selective for D3 versus D2 receptors. Neuroreport. 1995 Jan 26;6(2):329-32. DMO7MTX RU https://pubmed.ncbi.nlm.nih.gov/7756621 DMO7MTX DI DMO7MTX DMO7MTX DN N-propylnorapomorphine DMO7MTX MI TTS2PH3 DMO7MTX MN Dopamine D5 receptor (D5R) DMO7MTX MT DTT DMO7MTX MA Agonist DMO7MTX RN Cloning of the gene for a human dopamine D5 receptor with higher affinity for dopamine than D1. Nature. 1991 Apr 18;350(6319):614-9. DMO7MTX RU https://pubmed.ncbi.nlm.nih.gov/1826762 DM3JQYD DI DM3JQYD DM3JQYD DN N-propylnorlitebamine DM3JQYD MI TT1RS9F DM3JQYD MN Acetylcholinesterase (AChE) DM3JQYD MT DTT DM3JQYD MA Inhibitor DM3JQYD RN Litebamine N-homologues: preparation and anti-acetylcholinesterase activity. J Nat Prod. 1998 Jan;61(1):46-50. DM3JQYD RU https://pubmed.ncbi.nlm.nih.gov/9461651 DMWTPJH DI DMWTPJH DMWTPJH DN N-propynyl amidebenzenesulphonide DMWTPJH MI TTHQPL7 DMWTPJH MN Carbonic anhydrase I (CA-I) DMWTPJH MT DTT DMWTPJH MA Inhibitor DMWTPJH RN A novel class of carbonic anhydrase inhibitors: glycoconjugate benzene sulfonamides prepared by "click-tailing". J Med Chem. 2006 Nov 2;49(22):6539-48. DMWTPJH RU https://pubmed.ncbi.nlm.nih.gov/17064072 DMWTPJH DI DMWTPJH DMWTPJH DN N-propynyl amidebenzenesulphonide DMWTPJH MI TTANPDJ DMWTPJH MN Carbonic anhydrase II (CA-II) DMWTPJH MT DTT DMWTPJH MA Inhibitor DMWTPJH RN A novel class of carbonic anhydrase inhibitors: glycoconjugate benzene sulfonamides prepared by "click-tailing". J Med Chem. 2006 Nov 2;49(22):6539-48. DMWTPJH RU https://pubmed.ncbi.nlm.nih.gov/17064072 DMWTPJH DI DMWTPJH DMWTPJH DN N-propynyl amidebenzenesulphonide DMWTPJH MI TT2LVK8 DMWTPJH MN Carbonic anhydrase IX (CA-IX) DMWTPJH MT DTT DMWTPJH MA Inhibitor DMWTPJH RN A novel class of carbonic anhydrase inhibitors: glycoconjugate benzene sulfonamides prepared by "click-tailing". J Med Chem. 2006 Nov 2;49(22):6539-48. DMWTPJH RU https://pubmed.ncbi.nlm.nih.gov/17064072 DMWTPJH DI DMWTPJH DMWTPJH DN N-propynyl amidebenzenesulphonide DMWTPJH MI TTSYM0R DMWTPJH MN Carbonic anhydrase XII (CA-XII) DMWTPJH MT DTT DMWTPJH MA Inhibitor DMWTPJH RN Inhibition of membrane-associated carbonic anhydrase isozymes IX, XII and XIV with a library of glycoconjugate benzenesulfonamides. Bioorg Med Chem Lett. 2007 Feb 15;17(4):987-92. DMWTPJH RU https://pubmed.ncbi.nlm.nih.gov/17157501 DMWTPJH DI DMWTPJH DMWTPJH DN N-propynyl amidebenzenesulphonide DMWTPJH MI TTEYTKG DMWTPJH MN Carbonic anhydrase XIV (CA-XIV) DMWTPJH MT DTT DMWTPJH MA Inhibitor DMWTPJH RN Inhibition of membrane-associated carbonic anhydrase isozymes IX, XII and XIV with a library of glycoconjugate benzenesulfonamides. Bioorg Med Chem Lett. 2007 Feb 15;17(4):987-92. DMWTPJH RU https://pubmed.ncbi.nlm.nih.gov/17157501 DMYB2EZ DI DMYB2EZ DMYB2EZ DN NPRx-30 DMYB2EZ MI TT1RS9F DMYB2EZ MN Acetylcholinesterase (AChE) DMYB2EZ MT DTT DMYB2EZ MA Modulator DMYB2EZ RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2465). DMYB2EZ RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2465 DMMUY73 DI DMMUY73 DMMUY73 DN NPT-500 DMMUY73 MI TTSQIFT DMMUY73 MN 5-HT 1A receptor (HTR1A) DMMUY73 MT DTT DMMUY73 MA Modulator DMMUY73 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1). DMMUY73 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1 DMMR7DI DI DMMR7DI DMMR7DI DN N-p-Tolyl-1'H-phenothiazine-1'-carboxamide DMMR7DI MI TTEB0GD DMMR7DI MN Cholinesterase (BCHE) DMMR7DI MT DTT DMMR7DI MA Inhibitor DMMR7DI RN Differential binding of phenothiazine urea derivatives to wild-type human cholinesterases and butyrylcholinesterase mutants. Bioorg Med Chem. 2010 Mar 15;18(6):2232-2244. DMMR7DI RU https://pubmed.ncbi.nlm.nih.gov/20181484 DM1MOG8 DI DM1MOG8 DM1MOG8 DN NPY-1 antagonist DM1MOG8 MI TTRK9JT DM1MOG8 MN Neuropeptide Y receptor type 1 (NPY1R) DM1MOG8 MT DTT DM1MOG8 MA Antagonist DM1MOG8 RN Emerging drugs for eating disorder treatment. Expert Opin Emerg Drugs. 2006 May;11(2):315-36. DM1MOG8 RU https://pubmed.ncbi.nlm.nih.gov/16634704 DMMV1YN DI DMMV1YN DMMV1YN DN N-Pyridoxyl-Glycine-5-Monophosphate DMMV1YN MI TTUMGNO DMMV1YN MN Ornithine decarboxylase (ODC1) DMMV1YN MT DTT DMMV1YN MA Inhibitor DMMV1YN RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMMV1YN RU https://pubmed.ncbi.nlm.nih.gov/17139284 DM3ZHBO DI DM3ZHBO DM3ZHBO DN N'-Pyridoxyl-Lysine-5'-Monophosphate DM3ZHBO MI TTDU0HP DM3ZHBO MN Bacterial Cystathionine gamma-synthase (Bact metB) DM3ZHBO MT DTT DM3ZHBO MA Inhibitor DM3ZHBO RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DM3ZHBO RU https://pubmed.ncbi.nlm.nih.gov/17139284 DM3ZHBO DI DM3ZHBO DM3ZHBO DN N'-Pyridoxyl-Lysine-5'-Monophosphate DM3ZHBO MI TTZHY6R DM3ZHBO MN Glycogen phosphorylase muscle form (GP) DM3ZHBO MT DTT DM3ZHBO MA Inhibitor DM3ZHBO RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DM3ZHBO RU https://pubmed.ncbi.nlm.nih.gov/17139284 DM3ZHBO DI DM3ZHBO DM3ZHBO DN N'-Pyridoxyl-Lysine-5'-Monophosphate DM3ZHBO MI TTUMGNO DM3ZHBO MN Ornithine decarboxylase (ODC1) DM3ZHBO MT DTT DM3ZHBO MA Inhibitor DM3ZHBO RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DM3ZHBO RU https://pubmed.ncbi.nlm.nih.gov/17139284 DM3ZHBO DI DM3ZHBO DM3ZHBO DN N'-Pyridoxyl-Lysine-5'-Monophosphate DM3ZHBO MI TT1UY5C DM3ZHBO MN Pseudomonas Methionine gamma-lyase (Pseudo mdeA) DM3ZHBO MT DTT DM3ZHBO MA Inhibitor DM3ZHBO RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DM3ZHBO RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMAXHLK DI DMAXHLK DMAXHLK DN NQN-1 DMAXHLK MI TT5ZKDI DMAXHLK MN Histone deacetylase 6 (HDAC6) DMAXHLK MT DTT DMAXHLK MA Inhibitor DMAXHLK RN A novel class of small molecule inhibitors of HDAC6. ACS Chem Biol. 2012 Feb 17;7(2):331-9. DMAXHLK RU https://pubmed.ncbi.nlm.nih.gov/22047054 DMXP03H DI DMXP03H DMXP03H DN NRC-2694 DMXP03H MI TTGKNB4 DMXP03H MN Epidermal growth factor receptor (EGFR) DMXP03H MT DTT DMXP03H MA Inhibitor DMXP03H RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1797). DMXP03H RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1797 DMC9XJA DI DMC9XJA DMC9XJA DN NRP290 DMC9XJA MI TT27RFC DMC9XJA MN Opioid receptor delta (OPRD1) DMC9XJA MT DTT DMC9XJA MA Agonist DMC9XJA RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 317). DMC9XJA RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=317 DMC9XJA DI DMC9XJA DMC9XJA DN NRP290 DMC9XJA MI TTQW87Y DMC9XJA MN Opioid receptor kappa (OPRK1) DMC9XJA MT DTT DMC9XJA MA Agonist DMC9XJA RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 318). DMC9XJA RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=318 DMC9XJA DI DMC9XJA DMC9XJA DN NRP290 DMC9XJA MI TTKWM86 DMC9XJA MN Opioid receptor mu (MOP) DMC9XJA MT DTT DMC9XJA MA Agonist DMC9XJA RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 319). DMC9XJA RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=319 DM3IWP5 DI DM3IWP5 DM3IWP5 DN NRT-300 DM3IWP5 MI TTKWM86 DM3IWP5 MN Opioid receptor mu (MOP) DM3IWP5 MT DTT DM3IWP5 MA Modulator DM3IWP5 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 319). DM3IWP5 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=319 DML0N7D DI DML0N7D DML0N7D DN NS 2028 DML0N7D MI TTWNFC2 DML0N7D MN Soluble guanylyl cyclase (GUCY2D) DML0N7D MT DTT DML0N7D MA Inhibitor DML0N7D RN Characterization of NS 2028 as a specific inhibitor of soluble guanylyl cyclase. Br J Pharmacol. 1998 Jan;123(2):299-309. DML0N7D RU https://pubmed.ncbi.nlm.nih.gov/9489619 DM98VMZ DI DM98VMZ DM98VMZ DN NS-11757 DM98VMZ MI TTP835K DM98VMZ MN ATP-binding cassette transporter C8 (ABCC8) DM98VMZ MT DTT DM98VMZ MA Modulator DM98VMZ RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2944). DM98VMZ RU http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=2944 DMT97KV DI DMT97KV DMT97KV DN NS-1643 DMT97KV MI TTQ6VDM DMT97KV MN Voltage-gated potassium channel Kv11.1 (KCNH2) DMT97KV MT DTT DMT97KV MA Opener DMT97KV RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 572). DMT97KV RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=572 DM2S5ZF DI DM2S5ZF DM2S5ZF DN NS1738 DM2S5ZF MI TTH18TF DM2S5ZF MN Muscarinic acetylcholine receptor M5 (CHRM5) DM2S5ZF MT DTT DM2S5ZF MA Blocker (channel blocker) DM2S5ZF RN An allosteric modulator of the alpha7 nicotinic acetylcholine receptor possessing cognition-enhancing properties in vivo. J Pharmacol Exp Ther. 2007 Oct;323(1):294-307. DM2S5ZF RU https://pubmed.ncbi.nlm.nih.gov/17625074 DM2S5ZF DI DM2S5ZF DM2S5ZF DN NS1738 DM2S5ZF MI TTLA931 DM2S5ZF MN Neuronal acetylcholine receptor alpha-7 (CHRNA7) DM2S5ZF MT DTT DM2S5ZF MA Modulator (allosteric modulator) DM2S5ZF RN An allosteric modulator of the alpha7 nicotinic acetylcholine receptor possessing cognition-enhancing properties in vivo. J Pharmacol Exp Ther. 2007 Oct;323(1):294-307. DM2S5ZF RU https://pubmed.ncbi.nlm.nih.gov/17625074 DM2S5ZF DI DM2S5ZF DM2S5ZF DN NS1738 DM2S5ZF MI TT5KPZR DM2S5ZF MN Neuronal acetylcholine receptor beta-2 (CHRNB2) DM2S5ZF MT DTT DM2S5ZF MA Blocker (channel blocker) DM2S5ZF RN An allosteric modulator of the alpha7 nicotinic acetylcholine receptor possessing cognition-enhancing properties in vivo. J Pharmacol Exp Ther. 2007 Oct;323(1):294-307. DM2S5ZF RU https://pubmed.ncbi.nlm.nih.gov/17625074 DMVL5KS DI DMVL5KS DMVL5KS DN NS3763 DMVL5KS MI TT0MYE2 DMVL5KS MN Glutamate receptor ionotropic kainate 1 (GRIK1) DMVL5KS MT DTT DMVL5KS MA Antagonist DMVL5KS RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 450). DMVL5KS RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=450 DM629TD DI DM629TD DM629TD DN NS5818 DM629TD MI TTST1AJ DM629TD MN Chloride channel protein 7 (ClC-7) DM629TD MT DTT DM629TD MA Blocker (channel blocker) DM629TD RN The G215R mutation in the Cl-/H+-antiporter ClC-7 found in ADO II osteopetrosis does not abolish function but causes a severe trafficking defect. PLoS One. 2010 Sep 7;5(9):e12585. DM629TD RU https://pubmed.ncbi.nlm.nih.gov/20830208 DMWN8FU DI DMWN8FU DMWN8FU DN NS9283 DMWN8FU MI TT5KPZR DMWN8FU MN Neuronal acetylcholine receptor beta-2 (CHRNB2) DMWN8FU MT DTT DMWN8FU MA Modulator (allosteric modulator) DMWN8FU RN alpha4beta2 neuronal nicotinic receptor positive allosteric modulation: an approach for improving the therapeutic index of alpha4beta2 nAChR agonists in pain. Biochem Pharmacol. 2011 Oct 15;82(8):959-66. DMWN8FU RU https://pubmed.ncbi.nlm.nih.gov/21763685 DMLT8G9 DI DMLT8G9 DMLT8G9 DN NSC 19630 DMLT8G9 MI TT2H5WQ DMLT8G9 MN Werner syndrome ATP-dependent helicase (WRN) DMLT8G9 MT DTT DMLT8G9 MA Inhibitor DMLT8G9 RN WRN-targeted therapy using inhibitors NSC 19630 and NSC 617145 induce apoptosis in HTLV-1-transformed adult T-cell leukemia cells. J Hematol Oncol. 2016 Nov 9;9(1):121. DMLT8G9 RU https://pubmed.ncbi.nlm.nih.gov/27829440 DMX4DT7 DI DMX4DT7 DMX4DT7 DN NSC 665564 DMX4DT7 MI TT3PQ2Y DMX4DT7 MN Plasmodium Dihydroorotate dehydrogenase (Malaria DHOdehase) DMX4DT7 MT DTT DMX4DT7 MA Inhibitor DMX4DT7 RN Identification of a novel inhibitor (NSC 665564) of dihydroorotate dehydrogenase with a potency equivalent to brequinar. Biochem Biophys Res Commun. 1996 Jun 25;223(3):654-9. DMX4DT7 RU https://pubmed.ncbi.nlm.nih.gov/8687451 DMR6P9S DI DMR6P9S DMR6P9S DN NSC-106080 DMR6P9S MI TT8XK6L DMR6P9S MN Quinone reductase 1 (NQO1) DMR6P9S MT DTT DMR6P9S MA Inhibitor DMR6P9S RN In silico identification and biochemical evaluation of novel inhibitors of NRH:quinone oxidoreductase 2 (NQO2). Bioorg Med Chem Lett. 2010 Dec 15;20(24):7331-6. DMR6P9S RU https://pubmed.ncbi.nlm.nih.gov/21074425 DMR6P9S DI DMR6P9S DMR6P9S DN NSC-106080 DMR6P9S MI TTJLP0R DMR6P9S MN Quinone reductase 2 (NQO2) DMR6P9S MT DTT DMR6P9S MA Inhibitor DMR6P9S RN In silico identification and biochemical evaluation of novel inhibitors of NRH:quinone oxidoreductase 2 (NQO2). Bioorg Med Chem Lett. 2010 Dec 15;20(24):7331-6. DMR6P9S RU https://pubmed.ncbi.nlm.nih.gov/21074425 DM6ID8P DI DM6ID8P DM6ID8P DN NSC-106084 DM6ID8P MI TTHVCUP DM6ID8P MN DNA [cytosine-5]-methyltransferase (DNMT) DM6ID8P MT DTT DM6ID8P MA Inhibitor DM6ID8P RN Novel and selective DNA methyltransferase inhibitors: Docking-based virtual screening and experimental evaluation. Bioorg Med Chem. 2010 Jan 15;18(2):822-9. DM6ID8P RU https://pubmed.ncbi.nlm.nih.gov/20006515 DM6ID8P DI DM6ID8P DM6ID8P DN NSC-106084 DM6ID8P MI TT6VZ78 DM6ID8P MN DNA [cytosine-5]-methyltransferase 3B (DNMT3B) DM6ID8P MT DTT DM6ID8P MA Inhibitor DM6ID8P RN Novel and selective DNA methyltransferase inhibitors: Docking-based virtual screening and experimental evaluation. Bioorg Med Chem. 2010 Jan 15;18(2):822-9. DM6ID8P RU https://pubmed.ncbi.nlm.nih.gov/20006515 DMR2DTI DI DMR2DTI DMR2DTI DN NSC-106547 DMR2DTI MI TT8XK6L DMR2DTI MN Quinone reductase 1 (NQO1) DMR2DTI MT DTT DMR2DTI MA Inhibitor DMR2DTI RN In silico identification and biochemical characterization of novel inhibitors of NQO1. Bioorg Med Chem Lett. 2006 Dec 15;16(24):6246-54. DMR2DTI RU https://pubmed.ncbi.nlm.nih.gov/17011189 DMHK0F6 DI DMHK0F6 DMHK0F6 DN NSC-106970 DMHK0F6 MI TTML2WA DMHK0F6 MN Tubulin (TUB) DMHK0F6 MT DTT DMHK0F6 MA Inhibitor DMHK0F6 RN Structure-activity requirements for flavone cytotoxicity and binding to tubulin. J Med Chem. 1998 Jun 18;41(13):2333-8. DMHK0F6 RU https://pubmed.ncbi.nlm.nih.gov/9632366 DMHK0F6 DI DMHK0F6 DMHK0F6 DN NSC-106970 DMHK0F6 MI TTYFKSZ DMHK0F6 MN Tubulin beta (TUBB) DMHK0F6 MT DTT DMHK0F6 MA Inhibitor DMHK0F6 RN Structure-activity requirements for flavone cytotoxicity and binding to tubulin. J Med Chem. 1998 Jun 18;41(13):2333-8. DMHK0F6 RU https://pubmed.ncbi.nlm.nih.gov/9632366 DMPLUHT DI DMPLUHT DMPLUHT DN NSC-115890 DMPLUHT MI TTJLP0R DMPLUHT MN Quinone reductase 2 (NQO2) DMPLUHT MT DTT DMPLUHT MA Inhibitor DMPLUHT RN In silico identification and biochemical evaluation of novel inhibitors of NRH:quinone oxidoreductase 2 (NQO2). Bioorg Med Chem Lett. 2010 Dec 15;20(24):7331-6. DMPLUHT RU https://pubmed.ncbi.nlm.nih.gov/21074425 DMKHMS4 DI DMKHMS4 DMKHMS4 DN NSC-119910 DMKHMS4 MI TTHYBIX DMKHMS4 MN Heat shock protein 70 (HSP70) DMKHMS4 MT DTT DMKHMS4 MA Inhibitor DMKHMS4 RN In silico identification and biochemical evaluation of novel inhibitors of NRH:quinone oxidoreductase 2 (NQO2). Bioorg Med Chem Lett. 2010 Dec 15;20(24):7331-6. DMKHMS4 RU https://pubmed.ncbi.nlm.nih.gov/21074425 DM1MRFW DI DM1MRFW DM1MRFW DN NSC-119911 DM1MRFW MI TTHYBIX DM1MRFW MN Heat shock protein 70 (HSP70) DM1MRFW MT DTT DM1MRFW MA Inhibitor DM1MRFW RN In silico identification and biochemical evaluation of novel inhibitors of NRH:quinone oxidoreductase 2 (NQO2). Bioorg Med Chem Lett. 2010 Dec 15;20(24):7331-6. DM1MRFW RU https://pubmed.ncbi.nlm.nih.gov/21074425 DM1MRFW DI DM1MRFW DM1MRFW DN NSC-119911 DM1MRFW MI TTMQL3K DM1MRFW MN Lipopolysaccharide-associated protein 1 (HSPA8) DM1MRFW MT DTT DM1MRFW MA Inhibitor DM1MRFW RN In silico identification and biochemical evaluation of novel inhibitors of NRH:quinone oxidoreductase 2 (NQO2). Bioorg Med Chem Lett. 2010 Dec 15;20(24):7331-6. DM1MRFW RU https://pubmed.ncbi.nlm.nih.gov/21074425 DMVE69Y DI DMVE69Y DMVE69Y DN NSC-119913 DMVE69Y MI TTHYBIX DMVE69Y MN Heat shock protein 70 (HSP70) DMVE69Y MT DTT DMVE69Y MA Inhibitor DMVE69Y RN In silico identification and biochemical evaluation of novel inhibitors of NRH:quinone oxidoreductase 2 (NQO2). Bioorg Med Chem Lett. 2010 Dec 15;20(24):7331-6. DMVE69Y RU https://pubmed.ncbi.nlm.nih.gov/21074425 DMVE69Y DI DMVE69Y DMVE69Y DN NSC-119913 DMVE69Y MI TTMQL3K DMVE69Y MN Lipopolysaccharide-associated protein 1 (HSPA8) DMVE69Y MT DTT DMVE69Y MA Inhibitor DMVE69Y RN In silico identification and biochemical evaluation of novel inhibitors of NRH:quinone oxidoreductase 2 (NQO2). Bioorg Med Chem Lett. 2010 Dec 15;20(24):7331-6. DMVE69Y RU https://pubmed.ncbi.nlm.nih.gov/21074425 DMYMB4A DI DMYMB4A DMYMB4A DN NSC-122427 DMYMB4A MI TTSZLWK DMYMB4A MN Aromatase (CYP19A1) DMYMB4A MT DTT DMYMB4A MA Inhibitor DMYMB4A RN An efficient steroid pharmacophore-based strategy to identify new aromatase inhibitors. Eur J Med Chem. 2009 Oct;44(10):4121-7. DMYMB4A RU https://pubmed.ncbi.nlm.nih.gov/19500885 DM3NQDW DI DM3NQDW DM3NQDW DN NSC-125034 DM3NQDW MI TT12ABZ DM3NQDW MN Arachidonate 12-lipoxygenase (12-LOX) DM3NQDW MT DTT DM3NQDW MA Inhibitor DM3NQDW RN Discovery of platelet-type 12-human lipoxygenase selective inhibitors by high-throughput screening of structurally diverse libraries. Bioorg Med Chem. 2007 Nov 15;15(22):6900-8. DM3NQDW RU https://pubmed.ncbi.nlm.nih.gov/17826100 DMHGIB1 DI DMHGIB1 DMHGIB1 DN NSC-126445 DMHGIB1 MI TT9NVXQ DMHGIB1 MN Phosphoribosylaminoimidazolecarboxamide formyltransferase (ATIC) DMHGIB1 MT DTT DMHGIB1 MA Inhibitor DMHGIB1 RN Virtual screening of human 5-aminoimidazole-4-carboxamide ribonucleotide transformylase against the NCI diversity set by use of AutoDock to identif... J Med Chem. 2004 Dec 30;47(27):6681-90. DMHGIB1 RU https://pubmed.ncbi.nlm.nih.gov/15615517 DMJAO6Z DI DMJAO6Z DMJAO6Z DN NSC-12999 DMJAO6Z MI TTSZLWK DMJAO6Z MN Aromatase (CYP19A1) DMJAO6Z MT DTT DMJAO6Z MA Inhibitor DMJAO6Z RN Fast three dimensional pharmacophore virtual screening of new potent non-steroid aromatase inhibitors. J Med Chem. 2009 Jan 8;52(1):143-50. DMJAO6Z RU https://pubmed.ncbi.nlm.nih.gov/19072235 DMYJNS9 DI DMYJNS9 DMYJNS9 DN NSC-131736 DMYJNS9 MI TTSZLWK DMYJNS9 MN Aromatase (CYP19A1) DMYJNS9 MT DTT DMYJNS9 MA Inhibitor DMYJNS9 RN Fast three dimensional pharmacophore virtual screening of new potent non-steroid aromatase inhibitors. J Med Chem. 2009 Jan 8;52(1):143-50. DMYJNS9 RU https://pubmed.ncbi.nlm.nih.gov/19072235 DMKQYMX DI DMKQYMX DMKQYMX DN NSC-137546 DMKQYMX MI TTHVCUP DMKQYMX MN DNA [cytosine-5]-methyltransferase (DNMT) DMKQYMX MT DTT DMKQYMX MA Inhibitor DMKQYMX RN Novel and selective DNA methyltransferase inhibitors: Docking-based virtual screening and experimental evaluation. Bioorg Med Chem. 2010 Jan 15;18(2):822-9. DMKQYMX RU https://pubmed.ncbi.nlm.nih.gov/20006515 DMKQYMX DI DMKQYMX DMKQYMX DN NSC-137546 DMKQYMX MI TT6VZ78 DMKQYMX MN DNA [cytosine-5]-methyltransferase 3B (DNMT3B) DMKQYMX MT DTT DMKQYMX MA Inhibitor DMKQYMX RN Novel and selective DNA methyltransferase inhibitors: Docking-based virtual screening and experimental evaluation. Bioorg Med Chem. 2010 Jan 15;18(2):822-9. DMKQYMX RU https://pubmed.ncbi.nlm.nih.gov/20006515 DMH684Q DI DMH684Q DMH684Q DN NSC-138419 DMH684Q MI TTHVCUP DMH684Q MN DNA [cytosine-5]-methyltransferase (DNMT) DMH684Q MT DTT DMH684Q MA Inhibitor DMH684Q RN Novel and selective DNA methyltransferase inhibitors: Docking-based virtual screening and experimental evaluation. Bioorg Med Chem. 2010 Jan 15;18(2):822-9. DMH684Q RU https://pubmed.ncbi.nlm.nih.gov/20006515 DMH684Q DI DMH684Q DMH684Q DN NSC-138419 DMH684Q MI TT6VZ78 DMH684Q MN DNA [cytosine-5]-methyltransferase 3B (DNMT3B) DMH684Q MT DTT DMH684Q MA Inhibitor DMH684Q RN Novel and selective DNA methyltransferase inhibitors: Docking-based virtual screening and experimental evaluation. Bioorg Med Chem. 2010 Jan 15;18(2):822-9. DMH684Q RU https://pubmed.ncbi.nlm.nih.gov/20006515 DMW82SA DI DMW82SA DMW82SA DN NSC-154957 DMW82SA MI TTHVCUP DMW82SA MN DNA [cytosine-5]-methyltransferase (DNMT) DMW82SA MT DTT DMW82SA MA Inhibitor DMW82SA RN Novel and selective DNA methyltransferase inhibitors: Docking-based virtual screening and experimental evaluation. Bioorg Med Chem. 2010 Jan 15;18(2):822-9. DMW82SA RU https://pubmed.ncbi.nlm.nih.gov/20006515 DMW82SA DI DMW82SA DMW82SA DN NSC-154957 DMW82SA MI TT6VZ78 DMW82SA MN DNA [cytosine-5]-methyltransferase 3B (DNMT3B) DMW82SA MT DTT DMW82SA MA Inhibitor DMW82SA RN Novel and selective DNA methyltransferase inhibitors: Docking-based virtual screening and experimental evaluation. Bioorg Med Chem. 2010 Jan 15;18(2):822-9. DMW82SA RU https://pubmed.ncbi.nlm.nih.gov/20006515 DMDR460 DI DMDR460 DMDR460 DN NSC-158324 DMDR460 MI TTHVCUP DMDR460 MN DNA [cytosine-5]-methyltransferase (DNMT) DMDR460 MT DTT DMDR460 MA Inhibitor DMDR460 RN Novel and selective DNA methyltransferase inhibitors: Docking-based virtual screening and experimental evaluation. Bioorg Med Chem. 2010 Jan 15;18(2):822-9. DMDR460 RU https://pubmed.ncbi.nlm.nih.gov/20006515 DMDR460 DI DMDR460 DMDR460 DN NSC-158324 DMDR460 MI TT6VZ78 DMDR460 MN DNA [cytosine-5]-methyltransferase 3B (DNMT3B) DMDR460 MT DTT DMDR460 MA Inhibitor DMDR460 RN Novel and selective DNA methyltransferase inhibitors: Docking-based virtual screening and experimental evaluation. Bioorg Med Chem. 2010 Jan 15;18(2):822-9. DMDR460 RU https://pubmed.ncbi.nlm.nih.gov/20006515 DM9QW8N DI DM9QW8N DM9QW8N DN NSC-172033 DM9QW8N MI TT12ABZ DM9QW8N MN Arachidonate 12-lipoxygenase (12-LOX) DM9QW8N MT DTT DM9QW8N MA Inhibitor DM9QW8N RN Discovery of platelet-type 12-human lipoxygenase selective inhibitors by high-throughput screening of structurally diverse libraries. Bioorg Med Chem. 2007 Nov 15;15(22):6900-8. DM9QW8N RU https://pubmed.ncbi.nlm.nih.gov/17826100 DM9QW8N DI DM9QW8N DM9QW8N DN NSC-172033 DM9QW8N MI TTN9T81 DM9QW8N MN Arachidonate 15-lipoxygenase (15-LOX) DM9QW8N MT DTT DM9QW8N MA Inhibitor DM9QW8N RN Discovery of platelet-type 12-human lipoxygenase selective inhibitors by high-throughput screening of structurally diverse libraries. Bioorg Med Chem. 2007 Nov 15;15(22):6900-8. DM9QW8N RU https://pubmed.ncbi.nlm.nih.gov/17826100 DMNXDGQ DI DMNXDGQ DMNXDGQ DN NSC-1771 DMNXDGQ MI DEVDYN7 DMNXDGQ MN Cytochrome P450 2E1 (CYP2E1) DMNXDGQ MT DME DMNXDGQ MA Metabolism DMNXDGQ RN Effect of cytochrome P450 inducers on the metabolism and toxicity of thiram in rats. Vet Hum Toxicol. 2002 Dec;44(6):331-3. DMNXDGQ RU https://www.ncbi.nlm.nih.gov/pubmed/?term=12458634 DMNXDGQ DI DMNXDGQ DMNXDGQ DN NSC-1771 DMNXDGQ MI TTRMX3V DMNXDGQ MN Janus kinase 2 (JAK-2) DMNXDGQ MT DTT DMNXDGQ MA Inhibitor DMNXDGQ RN In silico identification and biochemical evaluation of novel inhibitors of NRH:quinone oxidoreductase 2 (NQO2). Bioorg Med Chem Lett. 2010 Dec 15;20(24):7331-6. DMNXDGQ RU https://pubmed.ncbi.nlm.nih.gov/21074425 DMXBRCI DI DMXBRCI DMXBRCI DN NSC-180246 DMXBRCI MI TTL53M6 DMXBRCI MN Induced myeloid leukemia cell differentiation protein Mcl-1 (MCL1) DMXBRCI MT DTT DMXBRCI MA Inhibitor DMXBRCI RN In silico identification and biochemical evaluation of novel inhibitors of NRH:quinone oxidoreductase 2 (NQO2). Bioorg Med Chem Lett. 2010 Dec 15;20(24):7331-6. DMXBRCI RU https://pubmed.ncbi.nlm.nih.gov/21074425 DMXBRCI DI DMXBRCI DMXBRCI DN NSC-180246 DMXBRCI MI TT4FDG6 DMXBRCI MN Voltage-gated calcium channel alpha Cav2.2 (CACNA1B) DMXBRCI MT DTT DMXBRCI MA Inhibitor DMXBRCI RN In silico identification and biochemical evaluation of novel inhibitors of NRH:quinone oxidoreductase 2 (NQO2). Bioorg Med Chem Lett. 2010 Dec 15;20(24):7331-6. DMXBRCI RU https://pubmed.ncbi.nlm.nih.gov/21074425 DMZFHL0 DI DMZFHL0 DMZFHL0 DN NSC-180969 DMZFHL0 MI TTJLP0R DMZFHL0 MN Quinone reductase 2 (NQO2) DMZFHL0 MT DTT DMZFHL0 MA Inhibitor DMZFHL0 RN In silico identification and biochemical evaluation of novel inhibitors of NRH:quinone oxidoreductase 2 (NQO2). Bioorg Med Chem Lett. 2010 Dec 15;20(24):7331-6. DMZFHL0 RU https://pubmed.ncbi.nlm.nih.gov/21074425 DMAQGIW DI DMAQGIW DMAQGIW DN NSC-204996 DMAQGIW MI TTJLP0R DMAQGIW MN Quinone reductase 2 (NQO2) DMAQGIW MT DTT DMAQGIW MA Inhibitor DMAQGIW RN In silico identification and biochemical evaluation of novel inhibitors of NRH:quinone oxidoreductase 2 (NQO2). Bioorg Med Chem Lett. 2010 Dec 15;20(24):7331-6. DMAQGIW RU https://pubmed.ncbi.nlm.nih.gov/21074425 DMOGV9F DI DMOGV9F DMOGV9F DN NSC-2113 DMOGV9F MI TT8XK6L DMOGV9F MN Quinone reductase 1 (NQO1) DMOGV9F MT DTT DMOGV9F MA Inhibitor DMOGV9F RN In silico identification and biochemical characterization of novel inhibitors of NQO1. Bioorg Med Chem Lett. 2006 Dec 15;16(24):6246-54. DMOGV9F RU https://pubmed.ncbi.nlm.nih.gov/17011189 DMM9PDR DI DMM9PDR DMM9PDR DN NSC-224124 DMM9PDR MI TT8XK6L DMM9PDR MN Quinone reductase 1 (NQO1) DMM9PDR MT DTT DMM9PDR MA Inhibitor DMM9PDR RN In silico identification and biochemical characterization of novel inhibitors of NQO1. Bioorg Med Chem Lett. 2006 Dec 15;16(24):6246-54. DMM9PDR RU https://pubmed.ncbi.nlm.nih.gov/17011189 DMJ91Y7 DI DMJ91Y7 DMJ91Y7 DN NSC-23180 DMJ91Y7 MI TT1RS9F DMJ91Y7 MN Acetylcholinesterase (AChE) DMJ91Y7 MT DTT DMJ91Y7 MA Inhibitor DMJ91Y7 RN Planarity and constraint of the carbonyl groups in 1,2-diones are determinants for selective inhibition of human carboxylesterase 1. J Med Chem. 2007 Nov 15;50(23):5727-34. DMJ91Y7 RU https://pubmed.ncbi.nlm.nih.gov/17941623 DMJ91Y7 DI DMJ91Y7 DMJ91Y7 DN NSC-23180 DMJ91Y7 MI TTEB0GD DMJ91Y7 MN Cholinesterase (BCHE) DMJ91Y7 MT DTT DMJ91Y7 MA Inhibitor DMJ91Y7 RN Planarity and constraint of the carbonyl groups in 1,2-diones are determinants for selective inhibition of human carboxylesterase 1. J Med Chem. 2007 Nov 15;50(23):5727-34. DMJ91Y7 RU https://pubmed.ncbi.nlm.nih.gov/17941623 DMJ91Y7 DI DMJ91Y7 DMJ91Y7 DN NSC-23180 DMJ91Y7 MI TTMF541 DMJ91Y7 MN Liver carboxylesterase (CES1) DMJ91Y7 MT DTT DMJ91Y7 MA Inhibitor DMJ91Y7 RN Planarity and constraint of the carbonyl groups in 1,2-diones are determinants for selective inhibition of human carboxylesterase 1. J Med Chem. 2007 Nov 15;50(23):5727-34. DMJ91Y7 RU https://pubmed.ncbi.nlm.nih.gov/17941623 DMWXNOI DI DMWXNOI DMWXNOI DN NSC-238146 DMWXNOI MI TTJLP0R DMWXNOI MN Quinone reductase 2 (NQO2) DMWXNOI MT DTT DMWXNOI MA Inhibitor DMWXNOI RN In silico identification and biochemical evaluation of novel inhibitors of NRH:quinone oxidoreductase 2 (NQO2). Bioorg Med Chem Lett. 2010 Dec 15;20(24):7331-6. DMWXNOI RU https://pubmed.ncbi.nlm.nih.gov/21074425 DM4RPBJ DI DM4RPBJ DM4RPBJ DN NSC-26699 DM4RPBJ MI TT9NVXQ DM4RPBJ MN Phosphoribosylaminoimidazolecarboxamide formyltransferase (ATIC) DM4RPBJ MT DTT DM4RPBJ MA Inhibitor DM4RPBJ RN Virtual screening of human 5-aminoimidazole-4-carboxamide ribonucleotide transformylase against the NCI diversity set by use of AutoDock to identif... J Med Chem. 2004 Dec 30;47(27):6681-90. DM4RPBJ RU https://pubmed.ncbi.nlm.nih.gov/15615517 DMNX245 DI DMNX245 DMNX245 DN NSC-26745 DMNX245 MI TTKPW01 DMNX245 MN Androgen receptor messenger RNA (AR mRNA) DMNX245 MT DTT DMNX245 MA Inhibitor DMNX245 RN Effect of flavonoids on androgen and glucocorticoid receptors based on in vitro reporter gene assay. Bioorg Med Chem Lett. 2009 Aug 15;19(16):4706-10. DMNX245 RU https://pubmed.ncbi.nlm.nih.gov/19592245 DMUNIWE DI DMUNIWE DMUNIWE DN NSC-270718 DMUNIWE MI TT2QM9D DMUNIWE MN Adenylate cyclase (ADCY) DMUNIWE MT DTT DMUNIWE MA Inhibitor DMUNIWE RN Structure-based development of novel adenylyl cyclase inhibitors. J Med Chem. 2008 Aug 14;51(15):4456-64. DMUNIWE RU https://pubmed.ncbi.nlm.nih.gov/18630896 DMANZIE DI DMANZIE DMANZIE DN NSC-27236 DMANZIE MI TTVKILB DMANZIE MN Prostaglandin G/H synthase 2 (COX-2) DMANZIE MT DTT DMANZIE MA Inhibitor DMANZIE RN Selective COX-2 inhibitors. Part 1: synthesis and biological evaluation of phenylazobenzenesulfonamides. Bioorg Med Chem Lett. 2006 Sep 1;16(17):4440-3. DMANZIE RU https://pubmed.ncbi.nlm.nih.gov/16814546 DMV2D8F DI DMV2D8F DMV2D8F DN NSC-275420 DMV2D8F MI TT8XK6L DMV2D8F MN Quinone reductase 1 (NQO1) DMV2D8F MT DTT DMV2D8F MA Inhibitor DMV2D8F RN In silico identification and biochemical characterization of novel inhibitors of NQO1. Bioorg Med Chem Lett. 2006 Dec 15;16(24):6246-54. DMV2D8F RU https://pubmed.ncbi.nlm.nih.gov/17011189 DMZU1L0 DI DMZU1L0 DMZU1L0 DN NSC-289311 DMZU1L0 MI TTSZLWK DMZU1L0 MN Aromatase (CYP19A1) DMZU1L0 MT DTT DMZU1L0 MA Inhibitor DMZU1L0 RN Fast three dimensional pharmacophore virtual screening of new potent non-steroid aromatase inhibitors. J Med Chem. 2009 Jan 8;52(1):143-50. DMZU1L0 RU https://pubmed.ncbi.nlm.nih.gov/19072235 DMNUSKT DI DMNUSKT DMNUSKT DN NSC-292213 DMNUSKT MI TT12ABZ DMNUSKT MN Arachidonate 12-lipoxygenase (12-LOX) DMNUSKT MT DTT DMNUSKT MA Inhibitor DMNUSKT RN Discovery of platelet-type 12-human lipoxygenase selective inhibitors by high-throughput screening of structurally diverse libraries. Bioorg Med Chem. 2007 Nov 15;15(22):6900-8. DMNUSKT RU https://pubmed.ncbi.nlm.nih.gov/17826100 DMNUSKT DI DMNUSKT DMNUSKT DN NSC-292213 DMNUSKT MI TT9NVXQ DMNUSKT MN Phosphoribosylaminoimidazolecarboxamide formyltransferase (ATIC) DMNUSKT MT DTT DMNUSKT MA Inhibitor DMNUSKT RN Virtual screening of human 5-aminoimidazole-4-carboxamide ribonucleotide transformylase against the NCI diversity set by use of AutoDock to identif... J Med Chem. 2004 Dec 30;47(27):6681-90. DMNUSKT RU https://pubmed.ncbi.nlm.nih.gov/15615517 DM6IF8N DI DM6IF8N DM6IF8N DN NSC-300853 DM6IF8N MI TTJLP0R DM6IF8N MN Quinone reductase 2 (NQO2) DM6IF8N MT DTT DM6IF8N MA Inhibitor DM6IF8N RN In silico identification and biochemical evaluation of novel inhibitors of NRH:quinone oxidoreductase 2 (NQO2). Bioorg Med Chem Lett. 2010 Dec 15;20(24):7331-6. DM6IF8N RU https://pubmed.ncbi.nlm.nih.gov/21074425 DMFBZEI DI DMFBZEI DMFBZEI DN NSC-30171 DMFBZEI MI TT9NVXQ DMFBZEI MN Phosphoribosylaminoimidazolecarboxamide formyltransferase (ATIC) DMFBZEI MT DTT DMFBZEI MA Inhibitor DMFBZEI RN Virtual screening of human 5-aminoimidazole-4-carboxamide ribonucleotide transformylase against the NCI diversity set by use of AutoDock to identif... J Med Chem. 2004 Dec 30;47(27):6681-90. DMFBZEI RU https://pubmed.ncbi.nlm.nih.gov/15615517 DMZYJU0 DI DMZYJU0 DMZYJU0 DN NSC-306843 DMZYJU0 MI TTJLP0R DMZYJU0 MN Quinone reductase 2 (NQO2) DMZYJU0 MT DTT DMZYJU0 MA Inhibitor DMZYJU0 RN In silico identification and biochemical evaluation of novel inhibitors of NRH:quinone oxidoreductase 2 (NQO2). Bioorg Med Chem Lett. 2010 Dec 15;20(24):7331-6. DMZYJU0 RU https://pubmed.ncbi.nlm.nih.gov/21074425 DMTPRXI DI DMTPRXI DMTPRXI DN NSC-316158 DMTPRXI MI TT8XK6L DMTPRXI MN Quinone reductase 1 (NQO1) DMTPRXI MT DTT DMTPRXI MA Inhibitor DMTPRXI RN In silico identification and biochemical characterization of novel inhibitors of NQO1. Bioorg Med Chem Lett. 2006 Dec 15;16(24):6246-54. DMTPRXI RU https://pubmed.ncbi.nlm.nih.gov/17011189 DMF3G06 DI DMF3G06 DMF3G06 DN NSC-319745 DMF3G06 MI TTHVCUP DMF3G06 MN DNA [cytosine-5]-methyltransferase (DNMT) DMF3G06 MT DTT DMF3G06 MA Inhibitor DMF3G06 RN Novel and selective DNA methyltransferase inhibitors: Docking-based virtual screening and experimental evaluation. Bioorg Med Chem. 2010 Jan 15;18(2):822-9. DMF3G06 RU https://pubmed.ncbi.nlm.nih.gov/20006515 DMF3G06 DI DMF3G06 DMF3G06 DN NSC-319745 DMF3G06 MI TT6VZ78 DMF3G06 MN DNA [cytosine-5]-methyltransferase 3B (DNMT3B) DMF3G06 MT DTT DMF3G06 MA Inhibitor DMF3G06 RN Novel and selective DNA methyltransferase inhibitors: Docking-based virtual screening and experimental evaluation. Bioorg Med Chem. 2010 Jan 15;18(2):822-9. DMF3G06 RU https://pubmed.ncbi.nlm.nih.gov/20006515 DMN50OT DI DMN50OT DMN50OT DN NSC-324572 DMN50OT MI TT9NVXQ DMN50OT MN Phosphoribosylaminoimidazolecarboxamide formyltransferase (ATIC) DMN50OT MT DTT DMN50OT MA Inhibitor DMN50OT RN Virtual screening of human 5-aminoimidazole-4-carboxamide ribonucleotide transformylase against the NCI diversity set by use of AutoDock to identif... J Med Chem. 2004 Dec 30;47(27):6681-90. DMN50OT RU https://pubmed.ncbi.nlm.nih.gov/15615517 DMK0H2P DI DMK0H2P DMK0H2P DN NSC-339580 DMK0H2P MI TT8XK6L DMK0H2P MN Quinone reductase 1 (NQO1) DMK0H2P MT DTT DMK0H2P MA Inhibitor DMK0H2P RN In silico identification and biochemical characterization of novel inhibitors of NQO1. Bioorg Med Chem Lett. 2006 Dec 15;16(24):6246-54. DMK0H2P RU https://pubmed.ncbi.nlm.nih.gov/17011189 DMITE1A DI DMITE1A DMITE1A DN NSC-339583 DMITE1A MI TT8XK6L DMITE1A MN Quinone reductase 1 (NQO1) DMITE1A MT DTT DMITE1A MA Inhibitor DMITE1A RN In silico identification and biochemical characterization of novel inhibitors of NQO1. Bioorg Med Chem Lett. 2006 Dec 15;16(24):6246-54. DMITE1A RU https://pubmed.ncbi.nlm.nih.gov/17011189 DMVGLH7 DI DMVGLH7 DMVGLH7 DN NSC-341622 DMVGLH7 MI TTGTQHC DMVGLH7 MN DNA topoisomerase I (TOP1) DMVGLH7 MT DTT DMVGLH7 MA Inhibitor DMVGLH7 RN Synthesis and biological evaluation of 14-(aminoalkyl-aminomethyl)aromathecins as topoisomerase I inhibitors: investigating the hypothesis of share... Bioorg Med Chem. 2009 Oct 15;17(20):7145-55. DMVGLH7 RU https://pubmed.ncbi.nlm.nih.gov/19783447 DM2UPSV DI DM2UPSV DM2UPSV DN NSC-345763 DM2UPSV MI TTHVCUP DM2UPSV MN DNA [cytosine-5]-methyltransferase (DNMT) DM2UPSV MT DTT DM2UPSV MA Inhibitor DM2UPSV RN Novel and selective DNA methyltransferase inhibitors: Docking-based virtual screening and experimental evaluation. Bioorg Med Chem. 2010 Jan 15;18(2):822-9. DM2UPSV RU https://pubmed.ncbi.nlm.nih.gov/20006515 DM2UPSV DI DM2UPSV DM2UPSV DN NSC-345763 DM2UPSV MI TT6VZ78 DM2UPSV MN DNA [cytosine-5]-methyltransferase 3B (DNMT3B) DM2UPSV MT DTT DM2UPSV MA Inhibitor DM2UPSV RN Novel and selective DNA methyltransferase inhibitors: Docking-based virtual screening and experimental evaluation. Bioorg Med Chem. 2010 Jan 15;18(2):822-9. DM2UPSV RU https://pubmed.ncbi.nlm.nih.gov/20006515 DM3TDEO DI DM3TDEO DM3TDEO DN NSC-348926 DM3TDEO MI TTHVCUP DM3TDEO MN DNA [cytosine-5]-methyltransferase (DNMT) DM3TDEO MT DTT DM3TDEO MA Inhibitor DM3TDEO RN Novel and selective DNA methyltransferase inhibitors: Docking-based virtual screening and experimental evaluation. Bioorg Med Chem. 2010 Jan 15;18(2):822-9. DM3TDEO RU https://pubmed.ncbi.nlm.nih.gov/20006515 DM3TDEO DI DM3TDEO DM3TDEO DN NSC-348926 DM3TDEO MI TT6VZ78 DM3TDEO MN DNA [cytosine-5]-methyltransferase 3B (DNMT3B) DM3TDEO MT DTT DM3TDEO MA Inhibitor DM3TDEO RN Novel and selective DNA methyltransferase inhibitors: Docking-based virtual screening and experimental evaluation. Bioorg Med Chem. 2010 Jan 15;18(2):822-9. DM3TDEO RU https://pubmed.ncbi.nlm.nih.gov/20006515 DMVL51I DI DMVL51I DMVL51I DN NSC-354279 DMVL51I MI TT8XK6L DMVL51I MN Quinone reductase 1 (NQO1) DMVL51I MT DTT DMVL51I MA Inhibitor DMVL51I RN In silico identification and biochemical characterization of novel inhibitors of NQO1. Bioorg Med Chem Lett. 2006 Dec 15;16(24):6246-54. DMVL51I RU https://pubmed.ncbi.nlm.nih.gov/17011189 DMEK5B2 DI DMEK5B2 DMEK5B2 DN NSC-356483 DMEK5B2 MI TTSZLWK DMEK5B2 MN Aromatase (CYP19A1) DMEK5B2 MT DTT DMEK5B2 MA Inhibitor DMEK5B2 RN Fast three dimensional pharmacophore virtual screening of new potent non-steroid aromatase inhibitors. J Med Chem. 2009 Jan 8;52(1):143-50. DMEK5B2 RU https://pubmed.ncbi.nlm.nih.gov/19072235 DM9LI7M DI DM9LI7M DM9LI7M DN NSC-356781 DM9LI7M MI TTSZLWK DM9LI7M MN Aromatase (CYP19A1) DM9LI7M MT DTT DM9LI7M MA Inhibitor DM9LI7M RN Fast three dimensional pharmacophore virtual screening of new potent non-steroid aromatase inhibitors. J Med Chem. 2009 Jan 8;52(1):143-50. DM9LI7M RU https://pubmed.ncbi.nlm.nih.gov/19072235 DMXT1EK DI DMXT1EK DMXT1EK DN NSC-356819 DMXT1EK MI TTJLP0R DMXT1EK MN Quinone reductase 2 (NQO2) DMXT1EK MT DTT DMXT1EK MA Inhibitor DMXT1EK RN In silico identification and biochemical evaluation of novel inhibitors of NRH:quinone oxidoreductase 2 (NQO2). Bioorg Med Chem Lett. 2010 Dec 15;20(24):7331-6. DMXT1EK RU https://pubmed.ncbi.nlm.nih.gov/21074425 DM9CM5V DI DM9CM5V DM9CM5V DN NSC-356820 DM9CM5V MI TTJLP0R DM9CM5V MN Quinone reductase 2 (NQO2) DM9CM5V MT DTT DM9CM5V MA Inhibitor DM9CM5V RN In silico identification and biochemical evaluation of novel inhibitors of NRH:quinone oxidoreductase 2 (NQO2). Bioorg Med Chem Lett. 2010 Dec 15;20(24):7331-6. DM9CM5V RU https://pubmed.ncbi.nlm.nih.gov/21074425 DMHUG1W DI DMHUG1W DMHUG1W DN NSC-359466 DMHUG1W MI TTJLP0R DMHUG1W MN Quinone reductase 2 (NQO2) DMHUG1W MT DTT DMHUG1W MA Inhibitor DMHUG1W RN In silico identification and biochemical evaluation of novel inhibitors of NRH:quinone oxidoreductase 2 (NQO2). Bioorg Med Chem Lett. 2010 Dec 15;20(24):7331-6. DMHUG1W RU https://pubmed.ncbi.nlm.nih.gov/21074425 DMR97X3 DI DMR97X3 DMR97X3 DN NSC-368272 DMR97X3 MI TTSZLWK DMR97X3 MN Aromatase (CYP19A1) DMR97X3 MT DTT DMR97X3 MA Inhibitor DMR97X3 RN Fast three dimensional pharmacophore virtual screening of new potent non-steroid aromatase inhibitors. J Med Chem. 2009 Jan 8;52(1):143-50. DMR97X3 RU https://pubmed.ncbi.nlm.nih.gov/19072235 DMR3IP5 DI DMR3IP5 DMR3IP5 DN NSC-368280 DMR3IP5 MI TTSZLWK DMR3IP5 MN Aromatase (CYP19A1) DMR3IP5 MT DTT DMR3IP5 MA Inhibitor DMR3IP5 RN Fast three dimensional pharmacophore virtual screening of new potent non-steroid aromatase inhibitors. J Med Chem. 2009 Jan 8;52(1):143-50. DMR3IP5 RU https://pubmed.ncbi.nlm.nih.gov/19072235 DMAQWM8 DI DMAQWM8 DMAQWM8 DN NSC-369087 DMAQWM8 MI TTSZLWK DMAQWM8 MN Aromatase (CYP19A1) DMAQWM8 MT DTT DMAQWM8 MA Inhibitor DMAQWM8 RN Fast three dimensional pharmacophore virtual screening of new potent non-steroid aromatase inhibitors. J Med Chem. 2009 Jan 8;52(1):143-50. DMAQWM8 RU https://pubmed.ncbi.nlm.nih.gov/19072235 DMLY6WX DI DMLY6WX DMLY6WX DN NSC-37031 DMLY6WX MI TT9NVXQ DMLY6WX MN Phosphoribosylaminoimidazolecarboxamide formyltransferase (ATIC) DMLY6WX MT DTT DMLY6WX MA Inhibitor DMLY6WX RN Virtual screening of human 5-aminoimidazole-4-carboxamide ribonucleotide transformylase against the NCI diversity set by use of AutoDock to identif... J Med Chem. 2004 Dec 30;47(27):6681-90. DMLY6WX RU https://pubmed.ncbi.nlm.nih.gov/15615517 DMZFULS DI DMZFULS DMZFULS DN NSC-37173 DMZFULS MI TT9NVXQ DMZFULS MN Phosphoribosylaminoimidazolecarboxamide formyltransferase (ATIC) DMZFULS MT DTT DMZFULS MA Inhibitor DMZFULS RN Virtual screening of human 5-aminoimidazole-4-carboxamide ribonucleotide transformylase against the NCI diversity set by use of AutoDock to identif... J Med Chem. 2004 Dec 30;47(27):6681-90. DMZFULS RU https://pubmed.ncbi.nlm.nih.gov/15615517 DMHO40Q DI DMHO40Q DMHO40Q DN NSC-380292 DMHO40Q MI TT84ETX DMHO40Q MN Human immunodeficiency virus Reverse transcriptase (HIV RT) DMHO40Q MT DTT DMHO40Q MA Inhibitor DMHO40Q RN New HIV-1 reverse transcriptase inhibitors based on a tricyclic benzothiophene scaffold: synthesis, resolution, and inhibitory activity. Bioorg Med Chem Lett. 2006 Jun 1;16(11):3034-8. DMHO40Q RU https://pubmed.ncbi.nlm.nih.gov/16527484 DMLGWHM DI DMLGWHM DMLGWHM DN NSC-381864 DMLGWHM MI TTJLP0R DMLGWHM MN Quinone reductase 2 (NQO2) DMLGWHM MT DTT DMLGWHM MA Inhibitor DMLGWHM RN In silico identification and biochemical evaluation of novel inhibitors of NRH:quinone oxidoreductase 2 (NQO2). Bioorg Med Chem Lett. 2010 Dec 15;20(24):7331-6. DMLGWHM RU https://pubmed.ncbi.nlm.nih.gov/21074425 DMMXZBK DI DMMXZBK DMMXZBK DN NSC-39851 DMMXZBK MI DERA3OF DMMXZBK MN Bile acid-CoA thioesterase (BAAT) DMMXZBK MT DME DMMXZBK MA Metabolism DMMXZBK RN Bile acid coenzyme A: amino acid N-acyltransferase in the amino acid conjugation of bile acids. Methods Enzymol. 2005;400:374-94. DMMXZBK RU https://www.ncbi.nlm.nih.gov/pubmed/?term=16399361 DM0214E DI DM0214E DM0214E DN NSC-401077 DM0214E MI TTHVCUP DM0214E MN DNA [cytosine-5]-methyltransferase (DNMT) DM0214E MT DTT DM0214E MA Inhibitor DM0214E RN Novel and selective DNA methyltransferase inhibitors: Docking-based virtual screening and experimental evaluation. Bioorg Med Chem. 2010 Jan 15;18(2):822-9. DM0214E RU https://pubmed.ncbi.nlm.nih.gov/20006515 DM0214E DI DM0214E DM0214E DN NSC-401077 DM0214E MI TT6VZ78 DM0214E MN DNA [cytosine-5]-methyltransferase 3B (DNMT3B) DM0214E MT DTT DM0214E MA Inhibitor DM0214E RN Novel and selective DNA methyltransferase inhibitors: Docking-based virtual screening and experimental evaluation. Bioorg Med Chem. 2010 Jan 15;18(2):822-9. DM0214E RU https://pubmed.ncbi.nlm.nih.gov/20006515 DMCFNMK DI DMCFNMK DMCFNMK DN NSC-40331 DMCFNMK MI TTFQAYR DMCFNMK MN Cholesteryl ester transfer protein (CETP) DMCFNMK MT DTT DMCFNMK MA Inhibitor DMCFNMK RN Discovery of new cholesteryl ester transfer protein inhibitors via ligand-based pharmacophore modeling and QSAR analysis followed by synthetic expl... Eur J Med Chem. 2010 Apr;45(4):1598-617. DMCFNMK RU https://pubmed.ncbi.nlm.nih.gov/20116902 DMKJWGP DI DMKJWGP DMKJWGP DN NSC-407228 DMKJWGP MI TTJFY5U DMKJWGP MN Adenosine A3 receptor (ADORA3) DMKJWGP MT DTT DMKJWGP MA Inhibitor DMKJWGP RN Interactions of flavonoids and other phytochemicals with adenosine receptors. J Med Chem. 1996 Feb 2;39(3):781-8. DMKJWGP RU https://pubmed.ncbi.nlm.nih.gov/8576921 DMQ6GBX DI DMQ6GBX DMQ6GBX DN NSC-45592 DMQ6GBX MI TT9NVXQ DMQ6GBX MN Phosphoribosylaminoimidazolecarboxamide formyltransferase (ATIC) DMQ6GBX MT DTT DMQ6GBX MA Inhibitor DMQ6GBX RN Virtual screening of human 5-aminoimidazole-4-carboxamide ribonucleotide transformylase against the NCI diversity set by use of AutoDock to identif... J Med Chem. 2004 Dec 30;47(27):6681-90. DMQ6GBX RU https://pubmed.ncbi.nlm.nih.gov/15615517 DMRZJL1 DI DMRZJL1 DMRZJL1 DN NSC-47729 DMRZJL1 MI TT9NVXQ DMRZJL1 MN Phosphoribosylaminoimidazolecarboxamide formyltransferase (ATIC) DMRZJL1 MT DTT DMRZJL1 MA Inhibitor DMRZJL1 RN Virtual screening of human 5-aminoimidazole-4-carboxamide ribonucleotide transformylase against the NCI diversity set by use of AutoDock to identif... J Med Chem. 2004 Dec 30;47(27):6681-90. DMRZJL1 RU https://pubmed.ncbi.nlm.nih.gov/15615517 DMTQP3V DI DMTQP3V DMTQP3V DN NSC-50187 DMTQP3V MI TTGP7BY DMTQP3V MN Monoamine oxidase type B (MAO-B) DMTQP3V MT DTT DMTQP3V MA Inhibitor DMTQP3V RN A new series of flavones, thioflavones, and flavanones as selective monoamine oxidase-B inhibitors. Bioorg Med Chem. 2010 Feb;18(3):1273-9. DMTQP3V RU https://pubmed.ncbi.nlm.nih.gov/20045650 DMY689Z DI DMY689Z DMY689Z DN NSC-527035 DMY689Z MI TTB6UM0 DMY689Z MN Fatty aldehyde dehydrogenase (ALDH3A2) DMY689Z MT DTT DMY689Z MA Inhibitor DMY689Z RN Exploring the structural requirements for inhibition of the ubiquitin E3 ligase breast cancer associated protein 2 (BCA2) as a treatment for breast... J Med Chem. 2010 Apr 8;53(7):2757-65. DMY689Z RU https://pubmed.ncbi.nlm.nih.gov/20222671 DMW2Q6N DI DMW2Q6N DMW2Q6N DN NSC-54162 DMW2Q6N MI TTHVCUP DMW2Q6N MN DNA [cytosine-5]-methyltransferase (DNMT) DMW2Q6N MT DTT DMW2Q6N MA Inhibitor DMW2Q6N RN Novel and selective DNA methyltransferase inhibitors: Docking-based virtual screening and experimental evaluation. Bioorg Med Chem. 2010 Jan 15;18(2):822-9. DMW2Q6N RU https://pubmed.ncbi.nlm.nih.gov/20006515 DMW2Q6N DI DMW2Q6N DMW2Q6N DN NSC-54162 DMW2Q6N MI TT6VZ78 DMW2Q6N MN DNA [cytosine-5]-methyltransferase 3B (DNMT3B) DMW2Q6N MT DTT DMW2Q6N MA Inhibitor DMW2Q6N RN Novel and selective DNA methyltransferase inhibitors: Docking-based virtual screening and experimental evaluation. Bioorg Med Chem. 2010 Jan 15;18(2):822-9. DMW2Q6N RU https://pubmed.ncbi.nlm.nih.gov/20006515 DMLEN4X DI DMLEN4X DMLEN4X DN NSC-56071 DMLEN4X MI TTHVCUP DMLEN4X MN DNA [cytosine-5]-methyltransferase (DNMT) DMLEN4X MT DTT DMLEN4X MA Inhibitor DMLEN4X RN Novel and selective DNA methyltransferase inhibitors: Docking-based virtual screening and experimental evaluation. Bioorg Med Chem. 2010 Jan 15;18(2):822-9. DMLEN4X RU https://pubmed.ncbi.nlm.nih.gov/20006515 DMLEN4X DI DMLEN4X DMLEN4X DN NSC-56071 DMLEN4X MI TT6VZ78 DMLEN4X MN DNA [cytosine-5]-methyltransferase 3B (DNMT3B) DMLEN4X MT DTT DMLEN4X MA Inhibitor DMLEN4X RN Novel and selective DNA methyltransferase inhibitors: Docking-based virtual screening and experimental evaluation. Bioorg Med Chem. 2010 Jan 15;18(2):822-9. DMLEN4X RU https://pubmed.ncbi.nlm.nih.gov/20006515 DMIRK41 DI DMIRK41 DMIRK41 DN NSC-57893 DMIRK41 MI TTHVCUP DMIRK41 MN DNA [cytosine-5]-methyltransferase (DNMT) DMIRK41 MT DTT DMIRK41 MA Inhibitor DMIRK41 RN Novel and selective DNA methyltransferase inhibitors: Docking-based virtual screening and experimental evaluation. Bioorg Med Chem. 2010 Jan 15;18(2):822-9. DMIRK41 RU https://pubmed.ncbi.nlm.nih.gov/20006515 DMIRK41 DI DMIRK41 DMIRK41 DN NSC-57893 DMIRK41 MI TT6VZ78 DMIRK41 MN DNA [cytosine-5]-methyltransferase 3B (DNMT3B) DMIRK41 MT DTT DMIRK41 MA Inhibitor DMIRK41 RN Novel and selective DNA methyltransferase inhibitors: Docking-based virtual screening and experimental evaluation. Bioorg Med Chem. 2010 Jan 15;18(2):822-9. DMIRK41 RU https://pubmed.ncbi.nlm.nih.gov/20006515 DMI6WA7 DI DMI6WA7 DMI6WA7 DN NSC-58046 DMI6WA7 MI TT9NVXQ DMI6WA7 MN Phosphoribosylaminoimidazolecarboxamide formyltransferase (ATIC) DMI6WA7 MT DTT DMI6WA7 MA Inhibitor DMI6WA7 RN Virtual screening of human 5-aminoimidazole-4-carboxamide ribonucleotide transformylase against the NCI diversity set by use of AutoDock to identif... J Med Chem. 2004 Dec 30;47(27):6681-90. DMI6WA7 RU https://pubmed.ncbi.nlm.nih.gov/15615517 DMX2YH7 DI DMX2YH7 DMX2YH7 DN NSC-6113 DMX2YH7 MI DEJGDUW DMX2YH7 MN Cytochrome P450 1A2 (CYP1A2) DMX2YH7 MT DME DMX2YH7 MA Metabolism DMX2YH7 RN Coleman J., Cox A. and Cowley N. (2011). Side Effects of Drugs Annual. Elsevier. DMX2YH7 RU https://www.sciencedirect.com/bookseries/side-effects-of-drugs-annual/vol/33/suppl/C DMD1XM0 DI DMD1XM0 DMD1XM0 DN NSC-613604 DMD1XM0 MI TTSZLWK DMD1XM0 MN Aromatase (CYP19A1) DMD1XM0 MT DTT DMD1XM0 MA Inhibitor DMD1XM0 RN An efficient steroid pharmacophore-based strategy to identify new aromatase inhibitors. Eur J Med Chem. 2009 Oct;44(10):4121-7. DMD1XM0 RU https://pubmed.ncbi.nlm.nih.gov/19500885 DMFXEIK DI DMFXEIK DMFXEIK DN NSC-621351 DMFXEIK MI TT8XK6L DMFXEIK MN Quinone reductase 1 (NQO1) DMFXEIK MT DTT DMFXEIK MA Inhibitor DMFXEIK RN In silico identification and biochemical evaluation of novel inhibitors of NRH:quinone oxidoreductase 2 (NQO2). Bioorg Med Chem Lett. 2010 Dec 15;20(24):7331-6. DMFXEIK RU https://pubmed.ncbi.nlm.nih.gov/21074425 DMM5UT9 DI DMM5UT9 DMM5UT9 DN NSC-622444 DMM5UT9 MI TTHVCUP DMM5UT9 MN DNA [cytosine-5]-methyltransferase (DNMT) DMM5UT9 MT DTT DMM5UT9 MA Inhibitor DMM5UT9 RN Novel and selective DNA methyltransferase inhibitors: Docking-based virtual screening and experimental evaluation. Bioorg Med Chem. 2010 Jan 15;18(2):822-9. DMM5UT9 RU https://pubmed.ncbi.nlm.nih.gov/20006515 DMM5UT9 DI DMM5UT9 DMM5UT9 DN NSC-622444 DMM5UT9 MI TT6VZ78 DMM5UT9 MN DNA [cytosine-5]-methyltransferase 3B (DNMT3B) DMM5UT9 MT DTT DMM5UT9 MA Inhibitor DMM5UT9 RN Novel and selective DNA methyltransferase inhibitors: Docking-based virtual screening and experimental evaluation. Bioorg Med Chem. 2010 Jan 15;18(2):822-9. DMM5UT9 RU https://pubmed.ncbi.nlm.nih.gov/20006515 DME35CB DI DME35CB DME35CB DN NSC-622445 DME35CB MI TTIQSC1 DME35CB MN Bacterial Lethal factor (Bact lef) DME35CB MT DTT DME35CB MA Inhibitor DME35CB RN Novel small-molecule inhibitors of anthrax lethal factor identified by high-throughput screening. J Med Chem. 2006 Aug 24;49(17):5232-44. DME35CB RU https://pubmed.ncbi.nlm.nih.gov/16913712 DME35CB DI DME35CB DME35CB DN NSC-622445 DME35CB MI TTHVCUP DME35CB MN DNA [cytosine-5]-methyltransferase (DNMT) DME35CB MT DTT DME35CB MA Inhibitor DME35CB RN Novel and selective DNA methyltransferase inhibitors: Docking-based virtual screening and experimental evaluation. Bioorg Med Chem. 2010 Jan 15;18(2):822-9. DME35CB RU https://pubmed.ncbi.nlm.nih.gov/20006515 DME35CB DI DME35CB DME35CB DN NSC-622445 DME35CB MI TT6VZ78 DME35CB MN DNA [cytosine-5]-methyltransferase 3B (DNMT3B) DME35CB MT DTT DME35CB MA Inhibitor DME35CB RN Novel and selective DNA methyltransferase inhibitors: Docking-based virtual screening and experimental evaluation. Bioorg Med Chem. 2010 Jan 15;18(2):822-9. DME35CB RU https://pubmed.ncbi.nlm.nih.gov/20006515 DMW437Z DI DMW437Z DMW437Z DN NSC-623548 DMW437Z MI TTHVCUP DMW437Z MN DNA [cytosine-5]-methyltransferase (DNMT) DMW437Z MT DTT DMW437Z MA Inhibitor DMW437Z RN Novel and selective DNA methyltransferase inhibitors: Docking-based virtual screening and experimental evaluation. Bioorg Med Chem. 2010 Jan 15;18(2):822-9. DMW437Z RU https://pubmed.ncbi.nlm.nih.gov/20006515 DMW437Z DI DMW437Z DMW437Z DN NSC-623548 DMW437Z MI TT6VZ78 DMW437Z MN DNA [cytosine-5]-methyltransferase 3B (DNMT3B) DMW437Z MT DTT DMW437Z MA Inhibitor DMW437Z RN Novel and selective DNA methyltransferase inhibitors: Docking-based virtual screening and experimental evaluation. Bioorg Med Chem. 2010 Jan 15;18(2):822-9. DMW437Z RU https://pubmed.ncbi.nlm.nih.gov/20006515 DM0GWAC DI DM0GWAC DM0GWAC DN NSC-625409 DM0GWAC MI TTSZLWK DM0GWAC MN Aromatase (CYP19A1) DM0GWAC MT DTT DM0GWAC MA Inhibitor DM0GWAC RN Fast three dimensional pharmacophore virtual screening of new potent non-steroid aromatase inhibitors. J Med Chem. 2009 Jan 8;52(1):143-50. DM0GWAC RU https://pubmed.ncbi.nlm.nih.gov/19072235 DM63G4R DI DM63G4R DM63G4R DN NSC-625487 DM63G4R MI TT84ETX DM63G4R MN Human immunodeficiency virus Reverse transcriptase (HIV RT) DM63G4R MT DTT DM63G4R MA Inhibitor DM63G4R RN Synthesis and biological activity of novel 1H,3H-thiazolo[3,4-a]benzimidazoles: non-nucleoside human immunodeficiency virus type 1 reverse transcriptase inhibitors. Antivir Chem Chemother. 1999 Jul;10(4):211-7. DM63G4R RU https://pubmed.ncbi.nlm.nih.gov/10480739 DMLG05U DI DMLG05U DMLG05U DN NSC-625987 DMLG05U MI TT7HF4W DMLG05U MN Cyclin-dependent kinase 2 (CDK2) DMLG05U MT DTT DMLG05U MA Inhibitor DMLG05U RN The p16 status of tumor cell lines identifies small molecule inhibitors specific for cyclin-dependent kinase 4. Clin Cancer Res. 1999 Dec;5(12):4279-86. DMLG05U RU https://pubmed.ncbi.nlm.nih.gov/10632371 DMLG05U DI DMLG05U DMLG05U DN NSC-625987 DMLG05U MI TT0PG8F DMLG05U MN Cyclin-dependent kinase 4 (CDK4) DMLG05U MT DTT DMLG05U MA Inhibitor DMLG05U RN The p16 status of tumor cell lines identifies small molecule inhibitors specific for cyclin-dependent kinase 4. Clin Cancer Res. 1999 Dec;5(12):4279-86. DMLG05U RU https://pubmed.ncbi.nlm.nih.gov/10632371 DMY7EAF DI DMY7EAF DMY7EAF DN NSC-637991 DMY7EAF MI TTJLP0R DMY7EAF MN Quinone reductase 2 (NQO2) DMY7EAF MT DTT DMY7EAF MA Inhibitor DMY7EAF RN Imidazoacridin-6-ones as novel inhibitors of the quinone oxidoreductase NQO2. Bioorg Med Chem Lett. 2010 May 1;20(9):2832-6. DMY7EAF RU https://pubmed.ncbi.nlm.nih.gov/20356739 DM0U7CK DI DM0U7CK DM0U7CK DN NSC-637992 DM0U7CK MI TTJLP0R DM0U7CK MN Quinone reductase 2 (NQO2) DM0U7CK MT DTT DM0U7CK MA Inhibitor DM0U7CK RN Imidazoacridin-6-ones as novel inhibitors of the quinone oxidoreductase NQO2. Bioorg Med Chem Lett. 2010 May 1;20(9):2832-6. DM0U7CK RU https://pubmed.ncbi.nlm.nih.gov/20356739 DM2HC8L DI DM2HC8L DM2HC8L DN NSC-637993 DM2HC8L MI TTJLP0R DM2HC8L MN Quinone reductase 2 (NQO2) DM2HC8L MT DTT DM2HC8L MA Inhibitor DM2HC8L RN Imidazoacridin-6-ones as novel inhibitors of the quinone oxidoreductase NQO2. Bioorg Med Chem Lett. 2010 May 1;20(9):2832-6. DM2HC8L RU https://pubmed.ncbi.nlm.nih.gov/20356739 DMKA8YT DI DMKA8YT DMKA8YT DN NSC-637994 DMKA8YT MI TTJLP0R DMKA8YT MN Quinone reductase 2 (NQO2) DMKA8YT MT DTT DMKA8YT MA Inhibitor DMKA8YT RN Imidazoacridin-6-ones as novel inhibitors of the quinone oxidoreductase NQO2. Bioorg Med Chem Lett. 2010 May 1;20(9):2832-6. DMKA8YT RU https://pubmed.ncbi.nlm.nih.gov/20356739 DMZCYM1 DI DMZCYM1 DMZCYM1 DN NSC-640353 DMZCYM1 MI TTJLP0R DMZCYM1 MN Quinone reductase 2 (NQO2) DMZCYM1 MT DTT DMZCYM1 MA Inhibitor DMZCYM1 RN In silico identification and biochemical evaluation of novel inhibitors of NRH:quinone oxidoreductase 2 (NQO2). Bioorg Med Chem Lett. 2010 Dec 15;20(24):7331-6. DMZCYM1 RU https://pubmed.ncbi.nlm.nih.gov/21074425 DM3DW6A DI DM3DW6A DM3DW6A DN NSC-640556 DM3DW6A MI TTJLP0R DM3DW6A MN Quinone reductase 2 (NQO2) DM3DW6A MT DTT DM3DW6A MA Inhibitor DM3DW6A RN In silico identification and biochemical evaluation of novel inhibitors of NRH:quinone oxidoreductase 2 (NQO2). Bioorg Med Chem Lett. 2010 Dec 15;20(24):7331-6. DM3DW6A RU https://pubmed.ncbi.nlm.nih.gov/21074425 DMPFC5U DI DMPFC5U DMPFC5U DN NSC-640558 DMPFC5U MI TTJLP0R DMPFC5U MN Quinone reductase 2 (NQO2) DMPFC5U MT DTT DMPFC5U MA Inhibitor DMPFC5U RN In silico identification and biochemical evaluation of novel inhibitors of NRH:quinone oxidoreductase 2 (NQO2). Bioorg Med Chem Lett. 2010 Dec 15;20(24):7331-6. DMPFC5U RU https://pubmed.ncbi.nlm.nih.gov/21074425 DMMT73G DI DMMT73G DMMT73G DN NSC-640559 DMMT73G MI TTJLP0R DMMT73G MN Quinone reductase 2 (NQO2) DMMT73G MT DTT DMMT73G MA Inhibitor DMMT73G RN In silico identification and biochemical evaluation of novel inhibitors of NRH:quinone oxidoreductase 2 (NQO2). Bioorg Med Chem Lett. 2010 Dec 15;20(24):7331-6. DMMT73G RU https://pubmed.ncbi.nlm.nih.gov/21074425 DMSJ06G DI DMSJ06G DMSJ06G DN NSC-640566 DMSJ06G MI TTJLP0R DMSJ06G MN Quinone reductase 2 (NQO2) DMSJ06G MT DTT DMSJ06G MA Inhibitor DMSJ06G RN In silico identification and biochemical evaluation of novel inhibitors of NRH:quinone oxidoreductase 2 (NQO2). Bioorg Med Chem Lett. 2010 Dec 15;20(24):7331-6. DMSJ06G RU https://pubmed.ncbi.nlm.nih.gov/21074425 DMC4Y0R DI DMC4Y0R DMC4Y0R DN NSC-640583 DMC4Y0R MI TTJLP0R DMC4Y0R MN Quinone reductase 2 (NQO2) DMC4Y0R MT DTT DMC4Y0R MA Inhibitor DMC4Y0R RN In silico identification and biochemical evaluation of novel inhibitors of NRH:quinone oxidoreductase 2 (NQO2). Bioorg Med Chem Lett. 2010 Dec 15;20(24):7331-6. DMC4Y0R RU https://pubmed.ncbi.nlm.nih.gov/21074425 DMY2API DI DMY2API DMY2API DN NSC-640584 DMY2API MI TTJLP0R DMY2API MN Quinone reductase 2 (NQO2) DMY2API MT DTT DMY2API MA Inhibitor DMY2API RN In silico identification and biochemical evaluation of novel inhibitors of NRH:quinone oxidoreductase 2 (NQO2). Bioorg Med Chem Lett. 2010 Dec 15;20(24):7331-6. DMY2API RU https://pubmed.ncbi.nlm.nih.gov/21074425 DMMBAR3 DI DMMBAR3 DMMBAR3 DN NSC-645808 DMMBAR3 MI TT8XK6L DMMBAR3 MN Quinone reductase 1 (NQO1) DMMBAR3 MT DTT DMMBAR3 MA Inhibitor DMMBAR3 RN In silico identification and biochemical characterization of novel inhibitors of NQO1. Bioorg Med Chem Lett. 2006 Dec 15;16(24):6246-54. DMMBAR3 RU https://pubmed.ncbi.nlm.nih.gov/17011189 DMMBAR3 DI DMMBAR3 DMMBAR3 DN NSC-645808 DMMBAR3 MI TTJLP0R DMMBAR3 MN Quinone reductase 2 (NQO2) DMMBAR3 MT DTT DMMBAR3 MA Inhibitor DMMBAR3 RN Imidazoacridin-6-ones as novel inhibitors of the quinone oxidoreductase NQO2. Bioorg Med Chem Lett. 2010 May 1;20(9):2832-6. DMMBAR3 RU https://pubmed.ncbi.nlm.nih.gov/20356739 DMCNIT2 DI DMCNIT2 DMCNIT2 DN NSC-645811 DMCNIT2 MI TTJLP0R DMCNIT2 MN Quinone reductase 2 (NQO2) DMCNIT2 MT DTT DMCNIT2 MA Inhibitor DMCNIT2 RN Imidazoacridin-6-ones as novel inhibitors of the quinone oxidoreductase NQO2. Bioorg Med Chem Lett. 2010 May 1;20(9):2832-6. DMCNIT2 RU https://pubmed.ncbi.nlm.nih.gov/20356739 DM1MPJ9 DI DM1MPJ9 DM1MPJ9 DN NSC-645812 DM1MPJ9 MI TTJLP0R DM1MPJ9 MN Quinone reductase 2 (NQO2) DM1MPJ9 MT DTT DM1MPJ9 MA Inhibitor DM1MPJ9 RN Imidazoacridin-6-ones as novel inhibitors of the quinone oxidoreductase NQO2. Bioorg Med Chem Lett. 2010 May 1;20(9):2832-6. DM1MPJ9 RU https://pubmed.ncbi.nlm.nih.gov/20356739 DMNJLW2 DI DMNJLW2 DMNJLW2 DN NSC-645827 DMNJLW2 MI TT8XK6L DMNJLW2 MN Quinone reductase 1 (NQO1) DMNJLW2 MT DTT DMNJLW2 MA Inhibitor DMNJLW2 RN In silico identification and biochemical characterization of novel inhibitors of NQO1. Bioorg Med Chem Lett. 2006 Dec 15;16(24):6246-54. DMNJLW2 RU https://pubmed.ncbi.nlm.nih.gov/17011189 DMSO215 DI DMSO215 DMSO215 DN NSC-645831 DMSO215 MI TTJLP0R DMSO215 MN Quinone reductase 2 (NQO2) DMSO215 MT DTT DMSO215 MA Inhibitor DMSO215 RN Imidazoacridin-6-ones as novel inhibitors of the quinone oxidoreductase NQO2. Bioorg Med Chem Lett. 2010 May 1;20(9):2832-6. DMSO215 RU https://pubmed.ncbi.nlm.nih.gov/20356739 DM1AD8T DI DM1AD8T DM1AD8T DN NSC-645833 DM1AD8T MI TTJLP0R DM1AD8T MN Quinone reductase 2 (NQO2) DM1AD8T MT DTT DM1AD8T MA Inhibitor DM1AD8T RN Imidazoacridin-6-ones as novel inhibitors of the quinone oxidoreductase NQO2. Bioorg Med Chem Lett. 2010 May 1;20(9):2832-6. DM1AD8T RU https://pubmed.ncbi.nlm.nih.gov/20356739 DMY5JFB DI DMY5JFB DMY5JFB DN NSC-645834 DMY5JFB MI TTJLP0R DMY5JFB MN Quinone reductase 2 (NQO2) DMY5JFB MT DTT DMY5JFB MA Inhibitor DMY5JFB RN Imidazoacridin-6-ones as novel inhibitors of the quinone oxidoreductase NQO2. Bioorg Med Chem Lett. 2010 May 1;20(9):2832-6. DMY5JFB RU https://pubmed.ncbi.nlm.nih.gov/20356739 DMKDVP7 DI DMKDVP7 DMKDVP7 DN NSC-645835 DMKDVP7 MI TTJLP0R DMKDVP7 MN Quinone reductase 2 (NQO2) DMKDVP7 MT DTT DMKDVP7 MA Inhibitor DMKDVP7 RN Imidazoacridin-6-ones as novel inhibitors of the quinone oxidoreductase NQO2. Bioorg Med Chem Lett. 2010 May 1;20(9):2832-6. DMKDVP7 RU https://pubmed.ncbi.nlm.nih.gov/20356739 DMQ13SI DI DMQ13SI DMQ13SI DN NSC-645836 DMQ13SI MI TTJLP0R DMQ13SI MN Quinone reductase 2 (NQO2) DMQ13SI MT DTT DMQ13SI MA Inhibitor DMQ13SI RN Imidazoacridin-6-ones as novel inhibitors of the quinone oxidoreductase NQO2. Bioorg Med Chem Lett. 2010 May 1;20(9):2832-6. DMQ13SI RU https://pubmed.ncbi.nlm.nih.gov/20356739 DM6F3HV DI DM6F3HV DM6F3HV DN NSC-649091 DM6F3HV MI TTJLP0R DM6F3HV MN Quinone reductase 2 (NQO2) DM6F3HV MT DTT DM6F3HV MA Inhibitor DM6F3HV RN In silico identification and biochemical evaluation of novel inhibitors of NRH:quinone oxidoreductase 2 (NQO2). Bioorg Med Chem Lett. 2010 Dec 15;20(24):7331-6. DM6F3HV RU https://pubmed.ncbi.nlm.nih.gov/21074425 DMFEGYB DI DMFEGYB DMFEGYB DN NSC-65069 DMFEGYB MI TT8XK6L DMFEGYB MN Quinone reductase 1 (NQO1) DMFEGYB MT DTT DMFEGYB MA Inhibitor DMFEGYB RN In silico identification and biochemical evaluation of novel inhibitors of NRH:quinone oxidoreductase 2 (NQO2). Bioorg Med Chem Lett. 2010 Dec 15;20(24):7331-6. DMFEGYB RU https://pubmed.ncbi.nlm.nih.gov/21074425 DMWY39L DI DMWY39L DMWY39L DN NSC-651016 DMWY39L MI TTFZYTO DMWY39L MN C-C chemokine receptor type 2 (CCR2) DMWY39L MT DTT DMWY39L MA Inhibitor DMWY39L RN Inhibition of in vitro and in vivo HIV replication by a distamycin analogue that interferes with chemokine receptor function: a candidate for chemo... J Med Chem. 1998 Jun 18;41(13):2184-93. DMWY39L RU https://pubmed.ncbi.nlm.nih.gov/9632350 DMW3QAK DI DMW3QAK DMW3QAK DN NSC-654077 DMW3QAK MI TTHQPL7 DMW3QAK MN Carbonic anhydrase I (CA-I) DMW3QAK MT DTT DMW3QAK MA Inhibitor DMW3QAK RN Recent developments of carbonic anhydrase inhibitors as potential anticancer drugs. J Med Chem. 2008 Jun 12;51(11):3051-6. DMW3QAK RU https://pubmed.ncbi.nlm.nih.gov/18348513 DMW3QAK DI DMW3QAK DMW3QAK DN NSC-654077 DMW3QAK MI TTANPDJ DMW3QAK MN Carbonic anhydrase II (CA-II) DMW3QAK MT DTT DMW3QAK MA Inhibitor DMW3QAK RN Recent developments of carbonic anhydrase inhibitors as potential anticancer drugs. J Med Chem. 2008 Jun 12;51(11):3051-6. DMW3QAK RU https://pubmed.ncbi.nlm.nih.gov/18348513 DMW3QAK DI DMW3QAK DMW3QAK DN NSC-654077 DMW3QAK MI TT2LVK8 DMW3QAK MN Carbonic anhydrase IX (CA-IX) DMW3QAK MT DTT DMW3QAK MA Inhibitor DMW3QAK RN Recent developments of carbonic anhydrase inhibitors as potential anticancer drugs. J Med Chem. 2008 Jun 12;51(11):3051-6. DMW3QAK RU https://pubmed.ncbi.nlm.nih.gov/18348513 DM52NOI DI DM52NOI DM52NOI DN NSC-656158 DM52NOI MI TT3WG5C DM52NOI MN Monoamine oxidase type A (MAO-A) DM52NOI MT DTT DM52NOI MA Inhibitor DM52NOI RN Synthesis and preclinical evaluations of 2-(2-fluorophenyl)-6,7-methylenedioxyquinolin-4-one monosodium phosphate (CHM-1-P-Na) as a potent antitumo... J Med Chem. 2010 Feb 25;53(4):1616-26. DM52NOI RU https://pubmed.ncbi.nlm.nih.gov/20102207 DM52NOI DI DM52NOI DM52NOI DN NSC-656158 DM52NOI MI TT056SO DM52NOI MN Stress-activated protein kinase JNK3 (JNK3) DM52NOI MT DTT DM52NOI MA Inhibitor DM52NOI RN Synthesis and preclinical evaluations of 2-(2-fluorophenyl)-6,7-methylenedioxyquinolin-4-one monosodium phosphate (CHM-1-P-Na) as a potent antitumo... J Med Chem. 2010 Feb 25;53(4):1616-26. DM52NOI RU https://pubmed.ncbi.nlm.nih.gov/20102207 DMXDNQ6 DI DMXDNQ6 DMXDNQ6 DN NSC-660838 DMXDNQ6 MI TTJLP0R DMXDNQ6 MN Quinone reductase 2 (NQO2) DMXDNQ6 MT DTT DMXDNQ6 MA Inhibitor DMXDNQ6 RN Imidazoacridin-6-ones as novel inhibitors of the quinone oxidoreductase NQO2. Bioorg Med Chem Lett. 2010 May 1;20(9):2832-6. DMXDNQ6 RU https://pubmed.ncbi.nlm.nih.gov/20356739 DM8LOCA DI DM8LOCA DM8LOCA DN NSC-660839 DM8LOCA MI TTJLP0R DM8LOCA MN Quinone reductase 2 (NQO2) DM8LOCA MT DTT DM8LOCA MA Inhibitor DM8LOCA RN Imidazoacridin-6-ones as novel inhibitors of the quinone oxidoreductase NQO2. Bioorg Med Chem Lett. 2010 May 1;20(9):2832-6. DM8LOCA RU https://pubmed.ncbi.nlm.nih.gov/20356739 DMB5PLD DI DMB5PLD DMB5PLD DN NSC-660840 DMB5PLD MI TTJLP0R DMB5PLD MN Quinone reductase 2 (NQO2) DMB5PLD MT DTT DMB5PLD MA Inhibitor DMB5PLD RN Imidazoacridin-6-ones as novel inhibitors of the quinone oxidoreductase NQO2. Bioorg Med Chem Lett. 2010 May 1;20(9):2832-6. DMB5PLD RU https://pubmed.ncbi.nlm.nih.gov/20356739 DMXHPV0 DI DMXHPV0 DMXHPV0 DN NSC-660841 DMXHPV0 MI TTJLP0R DMXHPV0 MN Quinone reductase 2 (NQO2) DMXHPV0 MT DTT DMXHPV0 MA Inhibitor DMXHPV0 RN Imidazoacridin-6-ones as novel inhibitors of the quinone oxidoreductase NQO2. Bioorg Med Chem Lett. 2010 May 1;20(9):2832-6. DMXHPV0 RU https://pubmed.ncbi.nlm.nih.gov/20356739 DMQ0S4B DI DMQ0S4B DMQ0S4B DN NSC-66209 DMQ0S4B MI TT915ZD DMQ0S4B MN Candida Mannose-6-phosphate isomerase (Candi PMI1) DMQ0S4B MT DTT DMQ0S4B MA Inhibitor DMQ0S4B RN In silico identification and biochemical evaluation of novel inhibitors of NRH:quinone oxidoreductase 2 (NQO2). Bioorg Med Chem Lett. 2010 Dec 15;20(24):7331-6. DMQ0S4B RU https://pubmed.ncbi.nlm.nih.gov/21074425 DMQ0S4B DI DMQ0S4B DMQ0S4B DN NSC-66209 DMQ0S4B MI TTL53M6 DMQ0S4B MN Induced myeloid leukemia cell differentiation protein Mcl-1 (MCL1) DMQ0S4B MT DTT DMQ0S4B MA Inhibitor DMQ0S4B RN In silico identification and biochemical evaluation of novel inhibitors of NRH:quinone oxidoreductase 2 (NQO2). Bioorg Med Chem Lett. 2010 Dec 15;20(24):7331-6. DMQ0S4B RU https://pubmed.ncbi.nlm.nih.gov/21074425 DMEXW31 DI DMEXW31 DMEXW31 DN NSC-663284 DMEXW31 MI TTESBNC DMEXW31 MN M-phase inducer phosphatase 3 (MPIP3) DMEXW31 MT DTT DMEXW31 MA Inhibitor DMEXW31 RN Synthesis and biological evaluation of novel heterocyclic quinones as inhibitors of the dual specificity protein phosphatase CDC25C. Bioorg Med Chem Lett. 2006 Jan 1;16(1):171-5. DMEXW31 RU https://pubmed.ncbi.nlm.nih.gov/16216500 DMEF603 DI DMEF603 DMEF603 DN NSC-664171 DMEF603 MI TTML2WA DMEF603 MN Tubulin (TUB) DMEF603 MT DTT DMEF603 MA Inhibitor DMEF603 RN Antitumor agents. 181. Synthesis and biological evaluation of 6,7,2',3',4'-substituted-1,2,3,4-tetrahydro-2-phenyl-4-quinolones as a new class of a... J Med Chem. 1998 Mar 26;41(7):1155-62. DMEF603 RU https://pubmed.ncbi.nlm.nih.gov/9544215 DMEF603 DI DMEF603 DMEF603 DN NSC-664171 DMEF603 MI TTYFKSZ DMEF603 MN Tubulin beta (TUBB) DMEF603 MT DTT DMEF603 MA Inhibitor DMEF603 RN Antitumor agents. 181. Synthesis and biological evaluation of 6,7,2',3',4'-substituted-1,2,3,4-tetrahydro-2-phenyl-4-quinolones as a new class of a... J Med Chem. 1998 Mar 26;41(7):1155-62. DMEF603 RU https://pubmed.ncbi.nlm.nih.gov/9544215 DMNQXE0 DI DMNQXE0 DMNQXE0 DN NSC-665126 DMNQXE0 MI TTJLP0R DMNQXE0 MN Quinone reductase 2 (NQO2) DMNQXE0 MT DTT DMNQXE0 MA Inhibitor DMNQXE0 RN In silico identification and biochemical evaluation of novel inhibitors of NRH:quinone oxidoreductase 2 (NQO2). Bioorg Med Chem Lett. 2010 Dec 15;20(24):7331-6. DMNQXE0 RU https://pubmed.ncbi.nlm.nih.gov/21074425 DMNMF0C DI DMNMF0C DMNMF0C DN NSC-666292 DMNMF0C MI TTSZLWK DMNMF0C MN Aromatase (CYP19A1) DMNMF0C MT DTT DMNMF0C MA Inhibitor DMNMF0C RN Fast three dimensional pharmacophore virtual screening of new potent non-steroid aromatase inhibitors. J Med Chem. 2009 Jan 8;52(1):143-50. DMNMF0C RU https://pubmed.ncbi.nlm.nih.gov/19072235 DMRVMA5 DI DMRVMA5 DMRVMA5 DN NSC-66811 DMRVMA5 MI TT9TE0O DMRVMA5 MN Mdm2 messenger RNA (MDM2 mRNA) DMRVMA5 MT DTT DMRVMA5 MA Inhibitor DMRVMA5 RN Discovery of a nanomolar inhibitor of the human murine double minute 2 (MDM2)-p53 interaction through an integrated, virtual database screening str... J Med Chem. 2006 Jun 29;49(13):3759-62. DMRVMA5 RU https://pubmed.ncbi.nlm.nih.gov/16789731 DMVFZKQ DI DMVFZKQ DMVFZKQ DN NSC-669977 DMVFZKQ MI TTJLP0R DMVFZKQ MN Quinone reductase 2 (NQO2) DMVFZKQ MT DTT DMVFZKQ MA Inhibitor DMVFZKQ RN In silico identification and biochemical evaluation of novel inhibitors of NRH:quinone oxidoreductase 2 (NQO2). Bioorg Med Chem Lett. 2010 Dec 15;20(24):7331-6. DMVFZKQ RU https://pubmed.ncbi.nlm.nih.gov/21074425 DMY4MPG DI DMY4MPG DMY4MPG DN NSC-676468 DMY4MPG MI TTJLP0R DMY4MPG MN Quinone reductase 2 (NQO2) DMY4MPG MT DTT DMY4MPG MA Inhibitor DMY4MPG RN In silico identification and biochemical evaluation of novel inhibitors of NRH:quinone oxidoreductase 2 (NQO2). Bioorg Med Chem Lett. 2010 Dec 15;20(24):7331-6. DMY4MPG RU https://pubmed.ncbi.nlm.nih.gov/21074425 DM35V46 DI DM35V46 DM35V46 DN NSC-677939 DM35V46 MI TTJLP0R DM35V46 MN Quinone reductase 2 (NQO2) DM35V46 MT DTT DM35V46 MA Inhibitor DM35V46 RN In silico identification and biochemical evaluation of novel inhibitors of NRH:quinone oxidoreductase 2 (NQO2). Bioorg Med Chem Lett. 2010 Dec 15;20(24):7331-6. DM35V46 RU https://pubmed.ncbi.nlm.nih.gov/21074425 DMPO2RU DI DMPO2RU DMPO2RU DN NSC-679036 DMPO2RU MI TTML2WA DMPO2RU MN Tubulin (TUB) DMPO2RU MT DTT DMPO2RU MA Inhibitor DMPO2RU RN Antitumor agents. 178. Synthesis and biological evaluation of substituted 2-aryl-1,8-naphthyridin-4(1H)-ones as antitumor agents that inhibit tubul... J Med Chem. 1997 Sep 12;40(19):3049-56. DMPO2RU RU https://pubmed.ncbi.nlm.nih.gov/9301667 DMPO2RU DI DMPO2RU DMPO2RU DN NSC-679036 DMPO2RU MI TTYFKSZ DMPO2RU MN Tubulin beta (TUBB) DMPO2RU MT DTT DMPO2RU MA Inhibitor DMPO2RU RN Antitumor agents. 178. Synthesis and biological evaluation of substituted 2-aryl-1,8-naphthyridin-4(1H)-ones as antitumor agents that inhibit tubul... J Med Chem. 1997 Sep 12;40(19):3049-56. DMPO2RU RU https://pubmed.ncbi.nlm.nih.gov/9301667 DMZ2KUB DI DMZ2KUB DMZ2KUB DN NSC-683634 DMZ2KUB MI TTSZLWK DMZ2KUB MN Aromatase (CYP19A1) DMZ2KUB MT DTT DMZ2KUB MA Inhibitor DMZ2KUB RN Fast three dimensional pharmacophore virtual screening of new potent non-steroid aromatase inhibitors. J Med Chem. 2009 Jan 8;52(1):143-50. DMZ2KUB RU https://pubmed.ncbi.nlm.nih.gov/19072235 DM0164B DI DM0164B DM0164B DN NSC-686549 DM0164B MI TTGECUM DM0164B MN Cot oncogene messenger RNA (MAP3K8 mRNA) DM0164B MT DTT DM0164B MA Inhibitor DM0164B RN A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases. Proc Natl Acad Sci U S A. 2007 Dec 18;104(51):20523-8. DM0164B RU https://pubmed.ncbi.nlm.nih.gov/18077363 DM0164B DI DM0164B DM0164B DN NSC-686549 DM0164B MI TTROQ37 DM0164B MN MAPK/ERK kinase kinase (MAP3K) DM0164B MT DTT DM0164B MA Inhibitor DM0164B RN A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases. Proc Natl Acad Sci U S A. 2007 Dec 18;104(51):20523-8. DM0164B RU https://pubmed.ncbi.nlm.nih.gov/18077363 DMKMTJ9 DI DMKMTJ9 DMKMTJ9 DN NSC-693571 DMKMTJ9 MI TTJLP0R DMKMTJ9 MN Quinone reductase 2 (NQO2) DMKMTJ9 MT DTT DMKMTJ9 MA Inhibitor DMKMTJ9 RN In silico identification and biochemical evaluation of novel inhibitors of NRH:quinone oxidoreductase 2 (NQO2). Bioorg Med Chem Lett. 2010 Dec 15;20(24):7331-6. DMKMTJ9 RU https://pubmed.ncbi.nlm.nih.gov/21074425 DMCP1I6 DI DMCP1I6 DMCP1I6 DN NSC-720622 DMCP1I6 MI TTJLP0R DMCP1I6 MN Quinone reductase 2 (NQO2) DMCP1I6 MT DTT DMCP1I6 MA Inhibitor DMCP1I6 RN In silico identification and biochemical evaluation of novel inhibitors of NRH:quinone oxidoreductase 2 (NQO2). Bioorg Med Chem Lett. 2010 Dec 15;20(24):7331-6. DMCP1I6 RU https://pubmed.ncbi.nlm.nih.gov/21074425 DMX0VQN DI DMX0VQN DMX0VQN DN NSC-73410 DMX0VQN MI TT8XK6L DMX0VQN MN Quinone reductase 1 (NQO1) DMX0VQN MT DTT DMX0VQN MA Inhibitor DMX0VQN RN In silico identification and biochemical characterization of novel inhibitors of NQO1. Bioorg Med Chem Lett. 2006 Dec 15;16(24):6246-54. DMX0VQN RU https://pubmed.ncbi.nlm.nih.gov/17011189 DMT6CV5 DI DMT6CV5 DMT6CV5 DN NSC-73613 DMT6CV5 MI TT1MPAY DMT6CV5 MN GABA(A) receptor alpha-1 (GABRA1) DMT6CV5 MT DTT DMT6CV5 MA Inhibitor DMT6CV5 RN Synthesis of halogenated/nitrated flavone derivatives and evaluation of their affinity for the central benzodiazepine receptor, Bioorg. Med. Chem. Lett. 7(15):2003-2008 (1997). DMT6CV5 RU http://www.sciencedirect.com/science/article/pii/S0960894X97003430 DMT6CV5 DI DMT6CV5 DMT6CV5 DN NSC-73613 DMT6CV5 MI TTNJYV2 DMT6CV5 MN Gamma-aminobutyric acid receptor (GAR) DMT6CV5 MT DTT DMT6CV5 MA Inhibitor DMT6CV5 RN Synthesis of halogenated/nitrated flavone derivatives and evaluation of their affinity for the central benzodiazepine receptor, Bioorg. Med. Chem. Lett. 7(15):2003-2008 (1997). DMT6CV5 RU http://www.sciencedirect.com/science/article/pii/S0960894X97003430 DM1ETX5 DI DM1ETX5 DM1ETX5 DN NSC-745794 DM1ETX5 MI TTQY2EJ DM1ETX5 MN TERT messenger RNA (TERT mRNA) DM1ETX5 MT DTT DM1ETX5 MA Inhibitor DM1ETX5 RN Synthesis, cytotoxicity and human telomerase inhibition activities of a series of 1,2-heteroannelated anthraquinones and anthra[1,2-d]imidazole-6,1... Bioorg Med Chem. 2009 Nov 1;17(21):7418-28. DM1ETX5 RU https://pubmed.ncbi.nlm.nih.gov/19804981 DMI2GFM DI DMI2GFM DMI2GFM DN NSC-745795 DMI2GFM MI TTQY2EJ DMI2GFM MN TERT messenger RNA (TERT mRNA) DMI2GFM MT DTT DMI2GFM MA Inhibitor DMI2GFM RN Synthesis, cytotoxicity and human telomerase inhibition activities of a series of 1,2-heteroannelated anthraquinones and anthra[1,2-d]imidazole-6,1... Bioorg Med Chem. 2009 Nov 1;17(21):7418-28. DMI2GFM RU https://pubmed.ncbi.nlm.nih.gov/19804981 DM8JMBI DI DM8JMBI DM8JMBI DN NSC-745796 DM8JMBI MI TTQY2EJ DM8JMBI MN TERT messenger RNA (TERT mRNA) DM8JMBI MT DTT DM8JMBI MA Inhibitor DM8JMBI RN Synthesis, cytotoxicity and human telomerase inhibition activities of a series of 1,2-heteroannelated anthraquinones and anthra[1,2-d]imidazole-6,1... Bioorg Med Chem. 2009 Nov 1;17(21):7418-28. DM8JMBI RU https://pubmed.ncbi.nlm.nih.gov/19804981 DM9YAPX DI DM9YAPX DM9YAPX DN NSC-745797 DM9YAPX MI TTQY2EJ DM9YAPX MN TERT messenger RNA (TERT mRNA) DM9YAPX MT DTT DM9YAPX MA Inhibitor DM9YAPX RN Synthesis, cytotoxicity and human telomerase inhibition activities of a series of 1,2-heteroannelated anthraquinones and anthra[1,2-d]imidazole-6,1... Bioorg Med Chem. 2009 Nov 1;17(21):7418-28. DM9YAPX RU https://pubmed.ncbi.nlm.nih.gov/19804981 DMSPQYV DI DMSPQYV DMSPQYV DN NSC-745798 DMSPQYV MI TTQY2EJ DMSPQYV MN TERT messenger RNA (TERT mRNA) DMSPQYV MT DTT DMSPQYV MA Inhibitor DMSPQYV RN Synthesis, cytotoxicity and human telomerase inhibition activities of a series of 1,2-heteroannelated anthraquinones and anthra[1,2-d]imidazole-6,1... Bioorg Med Chem. 2009 Nov 1;17(21):7418-28. DMSPQYV RU https://pubmed.ncbi.nlm.nih.gov/19804981 DML6OMH DI DML6OMH DML6OMH DN NSC-745799 DML6OMH MI TTQY2EJ DML6OMH MN TERT messenger RNA (TERT mRNA) DML6OMH MT DTT DML6OMH MA Inhibitor DML6OMH RN Synthesis, cytotoxicity and human telomerase inhibition activities of a series of 1,2-heteroannelated anthraquinones and anthra[1,2-d]imidazole-6,1... Bioorg Med Chem. 2009 Nov 1;17(21):7418-28. DML6OMH RU https://pubmed.ncbi.nlm.nih.gov/19804981 DMVA6R0 DI DMVA6R0 DMVA6R0 DN NSC-745883 DMVA6R0 MI TTQY2EJ DMVA6R0 MN TERT messenger RNA (TERT mRNA) DMVA6R0 MT DTT DMVA6R0 MA Inhibitor DMVA6R0 RN Synthesis, cytotoxicity and human telomerase inhibition activities of a series of 1,2-heteroannelated anthraquinones and anthra[1,2-d]imidazole-6,1... Bioorg Med Chem. 2009 Nov 1;17(21):7418-28. DMVA6R0 RU https://pubmed.ncbi.nlm.nih.gov/19804981 DM8W0J3 DI DM8W0J3 DM8W0J3 DN NSC-745884 DM8W0J3 MI TTQY2EJ DM8W0J3 MN TERT messenger RNA (TERT mRNA) DM8W0J3 MT DTT DM8W0J3 MA Inhibitor DM8W0J3 RN Synthesis, cytotoxicity and human telomerase inhibition activities of a series of 1,2-heteroannelated anthraquinones and anthra[1,2-d]imidazole-6,1... Bioorg Med Chem. 2009 Nov 1;17(21):7418-28. DM8W0J3 RU https://pubmed.ncbi.nlm.nih.gov/19804981 DMZQ803 DI DMZQ803 DMZQ803 DN NSC-745885 DMZQ803 MI TTQY2EJ DMZQ803 MN TERT messenger RNA (TERT mRNA) DMZQ803 MT DTT DMZQ803 MA Inhibitor DMZQ803 RN Synthesis, cytotoxicity and human telomerase inhibition activities of a series of 1,2-heteroannelated anthraquinones and anthra[1,2-d]imidazole-6,1... Bioorg Med Chem. 2009 Nov 1;17(21):7418-28. DMZQ803 RU https://pubmed.ncbi.nlm.nih.gov/19804981 DMHBYN5 DI DMHBYN5 DMHBYN5 DN NSC-745886 DMHBYN5 MI TTQY2EJ DMHBYN5 MN TERT messenger RNA (TERT mRNA) DMHBYN5 MT DTT DMHBYN5 MA Inhibitor DMHBYN5 RN Synthesis, cytotoxicity and human telomerase inhibition activities of a series of 1,2-heteroannelated anthraquinones and anthra[1,2-d]imidazole-6,1... Bioorg Med Chem. 2009 Nov 1;17(21):7418-28. DMHBYN5 RU https://pubmed.ncbi.nlm.nih.gov/19804981 DMG9BWY DI DMG9BWY DMG9BWY DN NSC-745887 DMG9BWY MI TTQY2EJ DMG9BWY MN TERT messenger RNA (TERT mRNA) DMG9BWY MT DTT DMG9BWY MA Inhibitor DMG9BWY RN Synthesis, cytotoxicity and human telomerase inhibition activities of a series of 1,2-heteroannelated anthraquinones and anthra[1,2-d]imidazole-6,1... Bioorg Med Chem. 2009 Nov 1;17(21):7418-28. DMG9BWY RU https://pubmed.ncbi.nlm.nih.gov/19804981 DMWHYND DI DMWHYND DMWHYND DN NSC-745888 DMWHYND MI TTQY2EJ DMWHYND MN TERT messenger RNA (TERT mRNA) DMWHYND MT DTT DMWHYND MA Inhibitor DMWHYND RN Synthesis, cytotoxicity and human telomerase inhibition activities of a series of 1,2-heteroannelated anthraquinones and anthra[1,2-d]imidazole-6,1... Bioorg Med Chem. 2009 Nov 1;17(21):7418-28. DMWHYND RU https://pubmed.ncbi.nlm.nih.gov/19804981 DM2GO7N DI DM2GO7N DM2GO7N DN NSC-746457 DM2GO7N MI TT6R7JZ DM2GO7N MN Histone deacetylase 1 (HDAC1) DM2GO7N MT DTT DM2GO7N MA Inhibitor DM2GO7N RN Histone deacetylase inhibitors through click chemistry. J Med Chem. 2008 Dec 11;51(23):7417-27. DM2GO7N RU https://pubmed.ncbi.nlm.nih.gov/19007204 DM8GZAM DI DM8GZAM DM8GZAM DN NSC-75308 DM8GZAM MI TTSZLWK DM8GZAM MN Aromatase (CYP19A1) DM8GZAM MT DTT DM8GZAM MA Inhibitor DM8GZAM RN Fast three dimensional pharmacophore virtual screening of new potent non-steroid aromatase inhibitors. J Med Chem. 2009 Jan 8;52(1):143-50. DM8GZAM RU https://pubmed.ncbi.nlm.nih.gov/19072235 DM82XAU DI DM82XAU DM82XAU DN NSC-77833 DM82XAU MI TTJLP0R DM82XAU MN Quinone reductase 2 (NQO2) DM82XAU MT DTT DM82XAU MA Inhibitor DM82XAU RN In silico identification and biochemical evaluation of novel inhibitors of NRH:quinone oxidoreductase 2 (NQO2). Bioorg Med Chem Lett. 2010 Dec 15;20(24):7331-6. DM82XAU RU https://pubmed.ncbi.nlm.nih.gov/21074425 DM8R12J DI DM8R12J DM8R12J DN NSC-78017 DM8R12J MI TTJLP0R DM8R12J MN Quinone reductase 2 (NQO2) DM8R12J MT DTT DM8R12J MA Inhibitor DM8R12J RN In silico identification and biochemical evaluation of novel inhibitors of NRH:quinone oxidoreductase 2 (NQO2). Bioorg Med Chem Lett. 2010 Dec 15;20(24):7331-6. DM8R12J RU https://pubmed.ncbi.nlm.nih.gov/21074425 DM7L3DE DI DM7L3DE DM7L3DE DN NSC-78021 DM7L3DE MI TTJLP0R DM7L3DE MN Quinone reductase 2 (NQO2) DM7L3DE MT DTT DM7L3DE MA Inhibitor DM7L3DE RN In silico identification and biochemical evaluation of novel inhibitors of NRH:quinone oxidoreductase 2 (NQO2). Bioorg Med Chem Lett. 2010 Dec 15;20(24):7331-6. DM7L3DE RU https://pubmed.ncbi.nlm.nih.gov/21074425 DMA53YD DI DMA53YD DMA53YD DN NSC-86715 DMA53YD MI TTJLP0R DMA53YD MN Quinone reductase 2 (NQO2) DMA53YD MT DTT DMA53YD MA Inhibitor DMA53YD RN In silico identification and biochemical evaluation of novel inhibitors of NRH:quinone oxidoreductase 2 (NQO2). Bioorg Med Chem Lett. 2010 Dec 15;20(24):7331-6. DMA53YD RU https://pubmed.ncbi.nlm.nih.gov/21074425 DMSYT0A DI DMSYT0A DMSYT0A DN NSC-87509 DMSYT0A MI TT4FDG6 DMSYT0A MN Voltage-gated calcium channel alpha Cav2.2 (CACNA1B) DMSYT0A MT DTT DMSYT0A MA Inhibitor DMSYT0A RN In silico identification and biochemical evaluation of novel inhibitors of NRH:quinone oxidoreductase 2 (NQO2). Bioorg Med Chem Lett. 2010 Dec 15;20(24):7331-6. DMSYT0A RU https://pubmed.ncbi.nlm.nih.gov/21074425 DM9WIHJ DI DM9WIHJ DM9WIHJ DN NSC-88915 DM9WIHJ MI TT2QM9D DM9WIHJ MN Adenylate cyclase (ADCY) DM9WIHJ MT DTT DM9WIHJ MA Inhibitor DM9WIHJ RN Structure-based development of novel adenylyl cyclase inhibitors. J Med Chem. 2008 Aug 14;51(15):4456-64. DM9WIHJ RU https://pubmed.ncbi.nlm.nih.gov/18630896 DM9WIHJ DI DM9WIHJ DM9WIHJ DN NSC-88915 DM9WIHJ MI TT9NVXQ DM9WIHJ MN Phosphoribosylaminoimidazolecarboxamide formyltransferase (ATIC) DM9WIHJ MT DTT DM9WIHJ MA Inhibitor DM9WIHJ RN Virtual screening of human 5-aminoimidazole-4-carboxamide ribonucleotide transformylase against the NCI diversity set by use of AutoDock to identif... J Med Chem. 2004 Dec 30;47(27):6681-90. DM9WIHJ RU https://pubmed.ncbi.nlm.nih.gov/15615517 DM9WIHJ DI DM9WIHJ DM9WIHJ DN NSC-88915 DM9WIHJ MI TTH0KSX DM9WIHJ MN Rhodopsin (RHO) DM9WIHJ MT DTT DM9WIHJ MA Inhibitor DM9WIHJ RN Modulating G-protein coupled receptor/G-protein signal transduction by small molecules suggested by virtual screening. J Med Chem. 2008 Sep 11;51(17):5297-303. DM9WIHJ RU https://pubmed.ncbi.nlm.nih.gov/18707087 DMGS6HB DI DMGS6HB DMGS6HB DN NSC-89508 DMGS6HB MI TTFQAYR DMGS6HB MN Cholesteryl ester transfer protein (CETP) DMGS6HB MT DTT DMGS6HB MA Inhibitor DMGS6HB RN Discovery of new cholesteryl ester transfer protein inhibitors via ligand-based pharmacophore modeling and QSAR analysis followed by synthetic expl... Eur J Med Chem. 2010 Apr;45(4):1598-617. DMGS6HB RU https://pubmed.ncbi.nlm.nih.gov/20116902 DMTOFS7 DI DMTOFS7 DMTOFS7 DN NSC-93358 DMTOFS7 MI TTSZLWK DMTOFS7 MN Aromatase (CYP19A1) DMTOFS7 MT DTT DMTOFS7 MA Inhibitor DMTOFS7 RN An efficient steroid pharmacophore-based strategy to identify new aromatase inhibitors. Eur J Med Chem. 2009 Oct;44(10):4121-7. DMTOFS7 RU https://pubmed.ncbi.nlm.nih.gov/19500885 DM2JPD4 DI DM2JPD4 DM2JPD4 DN NSC-93394 DM2JPD4 MI TT1MPAY DM2JPD4 MN GABA(A) receptor alpha-1 (GABRA1) DM2JPD4 MT DTT DM2JPD4 MA Inhibitor DM2JPD4 RN Synthesis of halogenated/nitrated flavone derivatives and evaluation of their affinity for the central benzodiazepine receptor, Bioorg. Med. Chem. Lett. 7(15):2003-2008 (1997). DM2JPD4 RU http://www.sciencedirect.com/science/article/pii/S0960894X97003430 DM2JPD4 DI DM2JPD4 DM2JPD4 DN NSC-93394 DM2JPD4 MI TTNJYV2 DM2JPD4 MN Gamma-aminobutyric acid receptor (GAR) DM2JPD4 MT DTT DM2JPD4 MA Inhibitor DM2JPD4 RN Synthesis of halogenated/nitrated flavone derivatives and evaluation of their affinity for the central benzodiazepine receptor, Bioorg. Med. Chem. Lett. 7(15):2003-2008 (1997). DM2JPD4 RU http://www.sciencedirect.com/science/article/pii/S0960894X97003430 DM3BZ7S DI DM3BZ7S DM3BZ7S DN NSC-93405 DM3BZ7S MI TTGP7BY DM3BZ7S MN Monoamine oxidase type B (MAO-B) DM3BZ7S MT DTT DM3BZ7S MA Inhibitor DM3BZ7S RN A new series of flavones, thioflavones, and flavanones as selective monoamine oxidase-B inhibitors. Bioorg Med Chem. 2010 Feb;18(3):1273-9. DM3BZ7S RU https://pubmed.ncbi.nlm.nih.gov/20045650 DM6VY3P DI DM6VY3P DM6VY3P DN NSC-94258 DM6VY3P MI TTFBNVI DM6VY3P MN Aldose reductase (AKR1B1) DM6VY3P MT DTT DM6VY3P MA Inhibitor DM6VY3P RN 1-Benzopyran-4-one antioxidants as aldose reductase inhibitors. J Med Chem. 1999 Jun 3;42(11):1881-93. DM6VY3P RU https://pubmed.ncbi.nlm.nih.gov/10354396 DM6VY3P DI DM6VY3P DM6VY3P DN NSC-94258 DM6VY3P MI TTSZLWK DM6VY3P MN Aromatase (CYP19A1) DM6VY3P MT DTT DM6VY3P MA Inhibitor DM6VY3P RN Pharmacophore modeling strategies for the development of novel nonsteroidal inhibitors of human aromatase (CYP19). Bioorg Med Chem Lett. 2010 May 15;20(10):3050-64. DM6VY3P RU https://pubmed.ncbi.nlm.nih.gov/20413308 DM6VY3P DI DM6VY3P DM6VY3P DN NSC-94258 DM6VY3P MI TTIWB6L DM6VY3P MN Estradiol 17 beta-dehydrogenase 1 (17-beta-HSD1) DM6VY3P MT DTT DM6VY3P MA Inhibitor DM6VY3P RN Discovery of nonsteroidal 17beta-hydroxysteroid dehydrogenase 1 inhibitors by pharmacophore-based screening of virtual compound libraries. J Med Chem. 2008 Jul 24;51(14):4188-99. DM6VY3P RU https://pubmed.ncbi.nlm.nih.gov/18533708 DM31CZK DI DM31CZK DM31CZK DN NSC-94891 DM31CZK MI TTSZLWK DM31CZK MN Aromatase (CYP19A1) DM31CZK MT DTT DM31CZK MA Inhibitor DM31CZK RN An efficient steroid pharmacophore-based strategy to identify new aromatase inhibitors. Eur J Med Chem. 2009 Oct;44(10):4121-7. DM31CZK RU https://pubmed.ncbi.nlm.nih.gov/19500885 DMX0TAM DI DMX0TAM DMX0TAM DN NSC-95397 DMX0TAM MI TTLZS4Q DMX0TAM MN M-phase inducer phosphatase 1 (MPIP1) DMX0TAM MT DTT DMX0TAM MA Inhibitor DMX0TAM RN Structure-based de novo design and biochemical evaluation of novel Cdc25 phosphatase inhibitors. Bioorg Med Chem Lett. 2009 Aug 1;19(15):4330-4. DMX0TAM RU https://pubmed.ncbi.nlm.nih.gov/19497739 DMX0TAM DI DMX0TAM DMX0TAM DN NSC-95397 DMX0TAM MI TTR0SWN DMX0TAM MN M-phase inducer phosphatase 2 (MPIP2) DMX0TAM MT DTT DMX0TAM MA Inhibitor DMX0TAM RN Novel naphthoquinone and quinolinedione inhibitors of CDC25 phosphatase activity with antiproliferative properties. Bioorg Med Chem. 2008 Oct 1;16(19):9040-9. DMX0TAM RU https://pubmed.ncbi.nlm.nih.gov/18789703 DM96X2U DI DM96X2U DM96X2U DN NSC-99495 DM96X2U MI TTJLP0R DM96X2U MN Quinone reductase 2 (NQO2) DM96X2U MT DTT DM96X2U MA Inhibitor DM96X2U RN In silico identification and biochemical evaluation of novel inhibitors of NRH:quinone oxidoreductase 2 (NQO2). Bioorg Med Chem Lett. 2010 Dec 15;20(24):7331-6. DM96X2U RU https://pubmed.ncbi.nlm.nih.gov/21074425 DMXZAIG DI DMXZAIG DMXZAIG DN NSC-99528 DMXZAIG MI TT8XK6L DMXZAIG MN Quinone reductase 1 (NQO1) DMXZAIG MT DTT DMXZAIG MA Inhibitor DMXZAIG RN In silico identification and biochemical evaluation of novel inhibitors of NRH:quinone oxidoreductase 2 (NQO2). Bioorg Med Chem Lett. 2010 Dec 15;20(24):7331-6. DMXZAIG RU https://pubmed.ncbi.nlm.nih.gov/21074425 DMXZAIG DI DMXZAIG DMXZAIG DN NSC-99528 DMXZAIG MI TTJLP0R DMXZAIG MN Quinone reductase 2 (NQO2) DMXZAIG MT DTT DMXZAIG MA Inhibitor DMXZAIG RN In silico identification and biochemical evaluation of novel inhibitors of NRH:quinone oxidoreductase 2 (NQO2). Bioorg Med Chem Lett. 2010 Dec 15;20(24):7331-6. DMXZAIG RU https://pubmed.ncbi.nlm.nih.gov/21074425 DMSLA8X DI DMSLA8X DMSLA8X DN NSFQ-105 DMSLA8X MI TTN6J5F DMSLA8X MN Bacterial DNA gyrase (Bact gyrase) DMSLA8X MT DTT DMSLA8X MA Modulator DMSLA8X RN Engineering the specificity of antibacterial fluoroquinolones: benzenesulfonamide modifications at C-7 of ciprofloxacin change its primary target i... Antimicrob Agents Chemother. 2000 Feb;44(2):320-5. DMSLA8X RU https://www.ncbi.nlm.nih.gov/pubmed/10639357 DMSLA8X DI DMSLA8X DMSLA8X DN NSFQ-105 DMSLA8X MI TTIXTO3 DMSLA8X MN Staphylococcus Topoisomerase IV (Stap-coc parC) DMSLA8X MT DTT DMSLA8X MA Modulator DMSLA8X RN Engineering the specificity of antibacterial fluoroquinolones: benzenesulfonamide modifications at C-7 of ciprofloxacin change its primary target i... Antimicrob Agents Chemother. 2000 Feb;44(2):320-5. DMSLA8X RU https://www.ncbi.nlm.nih.gov/pubmed/10639357 DMUHZ2V DI DMUHZ2V DMUHZ2V DN NT-69-L DMUHZ2V MI TTTUMEP DMUHZ2V MN Neurotensin receptor type 1 (NTSR1) DMUHZ2V MT DTT DMUHZ2V MA Modulator DMUHZ2V RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 309). DMUHZ2V RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=309 DMFIE0U DI DMFIE0U DMFIE0U DN NTE-1 DMFIE0U MI TT2EDHU DMFIE0U MN Insulin-degrading enzyme (IDE) DMFIE0U MT DTT DMFIE0U MA Inhibitor DMFIE0U RN Dual Exosite-binding Inhibitors of Insulin-degrading Enzyme Challenge Its Role as the Primary Mediator of Insulin Clearance in Vivo. J Biol Chem. 2015 Aug 14;290(33):20044-59. DMFIE0U RU https://pubmed.ncbi.nlm.nih.gov/26085101 DM4DB0W DI DM4DB0W DM4DB0W DN NTE-2 DM4DB0W MI TT2EDHU DM4DB0W MN Insulin-degrading enzyme (IDE) DM4DB0W MT DTT DM4DB0W MA Inhibitor DM4DB0W RN Dual Exosite-binding Inhibitors of Insulin-degrading Enzyme Challenge Its Role as the Primary Mediator of Insulin Clearance in Vivo. J Biol Chem. 2015 Aug 14;290(33):20044-59. DM4DB0W RU https://pubmed.ncbi.nlm.nih.gov/26085101 DMOPSJU DI DMOPSJU DMOPSJU DN N-tert-Butyl-1'H-phenothiazine-1'-carboxamide DMOPSJU MI TTEB0GD DMOPSJU MN Cholinesterase (BCHE) DMOPSJU MT DTT DMOPSJU MA Inhibitor DMOPSJU RN Differential binding of phenothiazine urea derivatives to wild-type human cholinesterases and butyrylcholinesterase mutants. Bioorg Med Chem. 2010 Mar 15;18(6):2232-2244. DMOPSJU RU https://pubmed.ncbi.nlm.nih.gov/20181484 DMNZ37C DI DMNZ37C DMNZ37C DN N-Tridecanoic Acid DMNZ37C MI TTO8QRU DMNZ37C MN Group IIA phospholipase A2 (GIIA sPLA2) DMNZ37C MT DTT DMNZ37C MA Inhibitor DMNZ37C RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DMNZ37C RU https://pubmed.ncbi.nlm.nih.gov/10592235 DMNZ37C DI DMNZ37C DMNZ37C DN N-Tridecanoic Acid DMNZ37C MI TT9V5JH DMNZ37C MN Phospholipase A2 (PLA2G1B) DMNZ37C MT DTT DMNZ37C MA Inhibitor DMNZ37C RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DMNZ37C RU https://pubmed.ncbi.nlm.nih.gov/10592235 DMZQXLS DI DMZQXLS DMZQXLS DN N-Trimethyllysine DMZQXLS MI TTV3NH6 DMZQXLS MN Calmodulin (CALM) DMZQXLS MT DTT DMZQXLS MA Inhibitor DMZQXLS RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMZQXLS RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMTHB2Y DI DMTHB2Y DMTHB2Y DN nTzDpa DMTHB2Y MI TTT2SVW DMTHB2Y MN PPAR-gamma messenger RNA (PPARG mRNA) DMTHB2Y MT DTT DMTHB2Y MA Agonist DMTHB2Y RN Distinct properties and advantages of a novel peroxisome proliferator-activated protein [gamma] selective modulator. Mol Endocrinol. 2003 Apr;17(4):662-76. DMTHB2Y RU https://pubmed.ncbi.nlm.nih.gov/12554792 DMEHMOK DI DMEHMOK DMEHMOK DN NU-1001-41 DMEHMOK MI TTWTSCV DMEHMOK MN RAC-alpha serine/threonine-protein kinase (AKT1) DMEHMOK MT DTT DMEHMOK RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1479). DMEHMOK RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1479 DMELYAX DI DMELYAX DMELYAX DN NU-6027 DMELYAX MI TTAMQ62 DMELYAX MN Cyclin A2 (CCNA2) DMELYAX MT DTT DMELYAX MA Inhibitor DMELYAX RN 4-Alkoxy-2,6-diaminopyrimidine derivatives: inhibitors of cyclin dependent kinases 1 and 2. Bioorg Med Chem Lett. 2003 Jan 20;13(2):217-22. DMELYAX RU https://pubmed.ncbi.nlm.nih.gov/12482427 DMELYAX DI DMELYAX DMELYAX DN NU-6027 DMELYAX MI TT7HF4W DMELYAX MN Cyclin-dependent kinase 2 (CDK2) DMELYAX MT DTT DMELYAX MA Inhibitor DMELYAX RN 4-Alkoxy-2,6-diaminopyrimidine derivatives: inhibitors of cyclin dependent kinases 1 and 2. Bioorg Med Chem Lett. 2003 Jan 20;13(2):217-22. DMELYAX RU https://pubmed.ncbi.nlm.nih.gov/12482427 DMMOFKD DI DMMOFKD DMMOFKD DN NU-6102 DMMOFKD MI TTTU902 DMMOFKD MN Checkpoint kinase-1 (CHK1) DMMOFKD MT DTT DMMOFKD MA Inhibitor DMMOFKD RN Triazolo[1,5-a]pyrimidines as novel CDK2 inhibitors: protein structure-guided design and SAR. Bioorg Med Chem Lett. 2006 Mar 1;16(5):1353-7. DMMOFKD RU https://pubmed.ncbi.nlm.nih.gov/16325401 DMMOFKD DI DMMOFKD DMMOFKD DN NU-6102 DMMOFKD MI TT7HF4W DMMOFKD MN Cyclin-dependent kinase 2 (CDK2) DMMOFKD MT DTT DMMOFKD MA Inhibitor DMMOFKD RN Dissecting the determinants of cyclin-dependent kinase 2 and cyclin-dependent kinase 4 inhibitor selectivity. J Med Chem. 2006 Sep 7;49(18):5470-7. DMMOFKD RU https://pubmed.ncbi.nlm.nih.gov/16942020 DMMOFKD DI DMMOFKD DMMOFKD DN NU-6102 DMMOFKD MI TT0PG8F DMMOFKD MN Cyclin-dependent kinase 4 (CDK4) DMMOFKD MT DTT DMMOFKD MA Inhibitor DMMOFKD RN Dissecting the determinants of cyclin-dependent kinase 2 and cyclin-dependent kinase 4 inhibitor selectivity. J Med Chem. 2006 Sep 7;49(18):5470-7. DMMOFKD RU https://pubmed.ncbi.nlm.nih.gov/16942020 DMMOFKD DI DMMOFKD DMMOFKD DN NU-6102 DMMOFKD MI TTRSMW9 DMMOFKD MN Glycogen synthase kinase-3 beta (GSK-3B) DMMOFKD MT DTT DMMOFKD MA Inhibitor DMMOFKD RN Triazolo[1,5-a]pyrimidines as novel CDK2 inhibitors: protein structure-guided design and SAR. Bioorg Med Chem Lett. 2006 Mar 1;16(5):1353-7. DMMOFKD RU https://pubmed.ncbi.nlm.nih.gov/16325401 DMMOFKD DI DMMOFKD DMMOFKD DN NU-6102 DMMOFKD MI TTYMGWX DMMOFKD MN PDK-1 messenger RNA (PDK-1 mRNA) DMMOFKD MT DTT DMMOFKD MA Inhibitor DMMOFKD RN Triazolo[1,5-a]pyrimidines as novel CDK2 inhibitors: protein structure-guided design and SAR. Bioorg Med Chem Lett. 2006 Mar 1;16(5):1353-7. DMMOFKD RU https://pubmed.ncbi.nlm.nih.gov/16325401 DMCUSG3 DI DMCUSG3 DMCUSG3 DN NU6140 DMCUSG3 MI TTH6V3D DMCUSG3 MN Cyclin-dependent kinase 1 (CDK1) DMCUSG3 MT DTT DMCUSG3 MA Inhibitor DMCUSG3 RN Potentiation of paclitaxel-induced apoptosis by the novel cyclin-dependent kinase inhibitor NU6140: a possible role for survivin down-regulation. Mol Cancer Ther. 2005 Sep;4(9):1328-37. DMCUSG3 RU https://pubmed.ncbi.nlm.nih.gov/16170024 DMCUSG3 DI DMCUSG3 DMCUSG3 DN NU6140 DMCUSG3 MI TT7HF4W DMCUSG3 MN Cyclin-dependent kinase 2 (CDK2) DMCUSG3 MT DTT DMCUSG3 MA Inhibitor DMCUSG3 RN Potentiation of paclitaxel-induced apoptosis by the novel cyclin-dependent kinase inhibitor NU6140: a possible role for survivin down-regulation. Mol Cancer Ther. 2005 Sep;4(9):1328-37. DMCUSG3 RU https://pubmed.ncbi.nlm.nih.gov/16170024 DMCUSG3 DI DMCUSG3 DMCUSG3 DN NU6140 DMCUSG3 MI TT0PG8F DMCUSG3 MN Cyclin-dependent kinase 4 (CDK4) DMCUSG3 MT DTT DMCUSG3 MA Inhibitor DMCUSG3 RN Potentiation of paclitaxel-induced apoptosis by the novel cyclin-dependent kinase inhibitor NU6140: a possible role for survivin down-regulation. Mol Cancer Ther. 2005 Sep;4(9):1328-37. DMCUSG3 RU https://pubmed.ncbi.nlm.nih.gov/16170024 DMCUSG3 DI DMCUSG3 DMCUSG3 DN NU6140 DMCUSG3 MI TTL4Q97 DMCUSG3 MN Cyclin-dependent kinase 5 (CDK5) DMCUSG3 MT DTT DMCUSG3 MA Inhibitor DMCUSG3 RN Potentiation of paclitaxel-induced apoptosis by the novel cyclin-dependent kinase inhibitor NU6140: a possible role for survivin down-regulation. Mol Cancer Ther. 2005 Sep;4(9):1328-37. DMCUSG3 RU https://pubmed.ncbi.nlm.nih.gov/16170024 DMCUSG3 DI DMCUSG3 DMCUSG3 DN NU6140 DMCUSG3 MI TTQYF7G DMCUSG3 MN Cyclin-dependent kinase 7 (CDK7) DMCUSG3 MT DTT DMCUSG3 MA Inhibitor DMCUSG3 RN Potentiation of paclitaxel-induced apoptosis by the novel cyclin-dependent kinase inhibitor NU6140: a possible role for survivin down-regulation. Mol Cancer Ther. 2005 Sep;4(9):1328-37. DMCUSG3 RU https://pubmed.ncbi.nlm.nih.gov/16170024 DMCUSG3 DI DMCUSG3 DMCUSG3 DN NU6140 DMCUSG3 MI TTXEZJ4 DMCUSG3 MN Tyrosine-protein kinase EIF2AK2 (p68) DMCUSG3 MT DTT DMCUSG3 MA Inhibitor DMCUSG3 RN Identification of new inhibitors of protein kinase R guided by statistical modeling. Bioorg Med Chem Lett. 2011 Jul 1;21(13):4108-14. DMCUSG3 RU https://pubmed.ncbi.nlm.nih.gov/21632247 DMDNUM5 DI DMDNUM5 DMDNUM5 DN NU-7432 DMDNUM5 MI TTK3PY9 DMDNUM5 MN DNA-dependent protein kinase catalytic (PRKDC) DMDNUM5 MT DTT DMDNUM5 MA Inhibitor DMDNUM5 RN Discovery of potent chromen-4-one inhibitors of the DNA-dependent protein kinase (DNA-PK) using a small-molecule library approach. J Med Chem. 2005 Dec 1;48(24):7829-46. DMDNUM5 RU https://pubmed.ncbi.nlm.nih.gov/16302822 DMEUV5R DI DMEUV5R DMEUV5R DN NU-8231 DMEUV5R MI TT7SBF5 DMEUV5R MN Cellular tumor antigen p53 (TP53) DMEUV5R MT DTT DMEUV5R MA Inhibitor DMEUV5R RN Small-molecule inhibitors of the MDM2-p53 protein-protein interaction based on an isoindolinone scaffold. J Med Chem. 2006 Oct 19;49(21):6209-21. DMEUV5R RU https://pubmed.ncbi.nlm.nih.gov/17034127 DMEUV5R DI DMEUV5R DMEUV5R DN NU-8231 DMEUV5R MI TT9TE0O DMEUV5R MN Mdm2 messenger RNA (MDM2 mRNA) DMEUV5R MT DTT DMEUV5R MA Inhibitor DMEUV5R RN Small-molecule inhibitors of the MDM2-p53 protein-protein interaction based on an isoindolinone scaffold. J Med Chem. 2006 Oct 19;49(21):6209-21. DMEUV5R RU https://pubmed.ncbi.nlm.nih.gov/17034127 DM5KXFI DI DM5KXFI DM5KXFI DN NUTLIN-3 DM5KXFI MI TT7SBF5 DM5KXFI MN Cellular tumor antigen p53 (TP53) DM5KXFI MT DTT DM5KXFI MA Inhibitor DM5KXFI RN Discovery and optimization of chromenotriazolopyrimidines as potent inhibitors of the mouse double minute 2-tumor protein 53 protein-protein intera... J Med Chem. 2009 Nov 26;52(22):7044-53. DM5KXFI RU https://pubmed.ncbi.nlm.nih.gov/19856920 DM5KXFI DI DM5KXFI DM5KXFI DN NUTLIN-3 DM5KXFI MI TT9TE0O DM5KXFI MN Mdm2 messenger RNA (MDM2 mRNA) DM5KXFI MT DTT DM5KXFI MA Inhibitor DM5KXFI RN Reaching for high-hanging fruit in drug discovery at protein-protein interfaces. Nature. 2007 Dec 13;450(7172):1001-9. DM5KXFI RU https://pubmed.ncbi.nlm.nih.gov/18075579 DMWLQV8 DI DMWLQV8 DMWLQV8 DN NV-07a DMWLQV8 MI TTXPQW1 DMWLQV8 MN Hormone unspecific (HOM) DMWLQV8 MT DTT DMWLQV8 MA Modulator DMWLQV8 RN UV radiation-induced immunosuppression is greater in men and prevented by topical nicotinamide. J Invest Dermatol. 2008 Feb;128(2):447-54. DMWLQV8 RU https://pubmed.ncbi.nlm.nih.gov/17882270 DM0BNYU DI DM0BNYU DM0BNYU DN NV-31 DM0BNYU MI TTZ8EM9 DM0BNYU MN Glycine receptor (GlyR) DM0BNYU MT DTT DM0BNYU RN Subunit-specific potentiation of recombinant glycine receptors by NV-31, a bilobalide-derived compound. Neurosci Lett. 2008 Apr 18;435(2):147-51. DM0BNYU RU https://pubmed.ncbi.nlm.nih.gov/18329806 DM6DRFC DI DM6DRFC DM6DRFC DN NVP 231 DM6DRFC MI TT9XRNV DM6DRFC MN Ceramide kinase (CERK) DM6DRFC MT DTT DM6DRFC MA Inhibitor DM6DRFC RN Targeting ceramide metabolism with a potent and specific ceramide kinase inhibitor. Mol Pharmacol. 2008 Oct;74(4):925-32. DM6DRFC RU https://pubmed.ncbi.nlm.nih.gov/18612076 DM8R16V DI DM8R16V DM8R16V DN NVP ACQ090 DM8R16V MI TTJX3UE DM8R16V MN Somatostatin receptor type 3 (SSTR3) DM8R16V MT DTT DM8R16V MA Antagonist DM8R16V RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 357). DM8R16V RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=357 DM9DURZ DI DM9DURZ DM9DURZ DN NVP-AAM077 DM9DURZ MI TTKJEMQ DM9DURZ MN Glutamate receptor ionotropic NMDA 2A (NMDAR2A) DM9DURZ MT DTT DM9DURZ MA Antagonist DM9DURZ RN Relating NMDA receptor function to receptor subunit composition: limitations of the pharmacological approach. J Neurosci. 2006 Feb 1;26(5):1331-3. DM9DURZ RU https://pubmed.ncbi.nlm.nih.gov/16452656 DM9DURZ DI DM9DURZ DM9DURZ DN NVP-AAM077 DM9DURZ MI TTN9D8E DM9DURZ MN Glutamate receptor ionotropic NMDA 2B (NMDAR2B) DM9DURZ MT DTT DM9DURZ MA Antagonist DM9DURZ RN Relating NMDA receptor function to receptor subunit composition: limitations of the pharmacological approach. J Neurosci. 2006 Feb 1;26(5):1331-3. DM9DURZ RU https://pubmed.ncbi.nlm.nih.gov/16452656 DMXL3CD DI DMXL3CD DMXL3CD DN NVP-ADW742 DMXL3CD MI TTHRID2 DMXL3CD MN Insulin-like growth factor I receptor (IGF1R) DMXL3CD MT DTT DMXL3CD MA Inhibitor DMXL3CD RN Emerging therapies for multiple myeloma. Expert Opin Emerg Drugs. 2009 Mar;14(1):99-127. DMXL3CD RU https://pubmed.ncbi.nlm.nih.gov/19249983 DMOV0QT DI DMOV0QT DMOV0QT DN NVP-PDF386 DMOV0QT MI TTICO5G DMOV0QT MN Staphylococcus Peptide deformylase (Stap-coc def) DMOV0QT MT DTT DMOV0QT MA Inhibitor DMOV0QT RN Comparative spectrum and activity of NVP-PDF386 (VRC4887), a new peptide deformylase inhibitor. J Antimicrob Chemother. 2003 Jan;51(1):157-61. DMOV0QT RU https://pubmed.ncbi.nlm.nih.gov/12493802 DMN90R6 DI DMN90R6 DMN90R6 DN NVP-SAA164 DMN90R6 MI TTG5QIA DMN90R6 MN B1 bradykinin receptor (BDKRB1) DMN90R6 MT DTT DMN90R6 MA Antagonist DMN90R6 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 659). DMN90R6 RU http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=659 DMFZXI2 DI DMFZXI2 DMFZXI2 DN NVP-TAE684 DMFZXI2 MI TTCBFJO DMFZXI2 MN Insulin receptor (INSR) DMFZXI2 MT DTT DMFZXI2 MA Inhibitor DMFZXI2 RN Identification of NVP-TAE684, a potent, selective, and efficacious inhibitor of NPM-ALK. Proc Natl Acad Sci U S A. 2007 Jan 2;104(1):270-5. DMFZXI2 RU https://pubmed.ncbi.nlm.nih.gov/17185414 DMBQRA8 DI DMBQRA8 DMBQRA8 DN NVX-207 DMBQRA8 MI TTB6T7O DMBQRA8 MN Caspase-9 (CASP9) DMBQRA8 MT DTT DMBQRA8 MA Modulator DMBQRA8 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1625). DMBQRA8 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1625 DMRYBK6 DI DMRYBK6 DMRYBK6 DN NW-1772 DMRYBK6 MI TTGP7BY DMRYBK6 MN Monoamine oxidase type B (MAO-B) DMRYBK6 MT DTT DMRYBK6 MA Inhibitor DMRYBK6 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2490). DMRYBK6 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2490 DM9VISB DI DM9VISB DM9VISB DN O-1602 DM9VISB MI TTNET8J DM9VISB MN G-protein coupled receptor 55 (GPR55) DM9VISB MT DTT DM9VISB MA Agonist DM9VISB RN International Union of Basic and Clinical Pharmacology. LXXIX. Cannabinoid receptors and their ligands: beyond CB and CB Pharmacol Rev. 2010 Dec;62(4):588-631. DM9VISB RU https://pubmed.ncbi.nlm.nih.gov/21079038 DM9VISB DI DM9VISB DM9VISB DN O-1602 DM9VISB MI TTSLJAR DM9VISB MN N-arachidonyl glycine receptor (GPR18) DM9VISB MT DTT DM9VISB MA Agonist DM9VISB RN Delta(9) -Tetrahydrocannabinol and N-arachidonyl glycine are full agonists at GPR18 receptors and induce migration in human endometrial HEC-1B cells. Br J Pharmacol. 2012 Apr;165(8):2414-24. DM9VISB RU https://pubmed.ncbi.nlm.nih.gov/21595653 DMCXMQJ DI DMCXMQJ DMCXMQJ DN O-1812 DMCXMQJ MI TT6OEDT DMCXMQJ MN Cannabinoid receptor 1 (CB1) DMCXMQJ MT DTT DMCXMQJ MA Agonist DMCXMQJ RN Highly selective CB(1) cannabinoid receptor ligands and novel CB(1)/VR(1) vanilloid receptor "hybrid" ligands. Biochem Biophys Res Commun. 2001 Feb 23;281(2):444-51. DMCXMQJ RU https://pubmed.ncbi.nlm.nih.gov/11181068 DMK8AGF DI DMK8AGF DMK8AGF DN O-2442 DMK8AGF MI TTVBI8W DMK8AGF MN Dopamine transporter (DAT) DMK8AGF MT DTT DMK8AGF MA Inhibitor DMK8AGF RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 927). DMK8AGF RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=927 DME78MS DI DME78MS DME78MS DN O2-Sulfo-Glucuronic Acid DME78MS MI TTMY81X DME78MS MN Heparin-binding growth factor 1 (FGF1) DME78MS MT DTT DME78MS MA Inhibitor DME78MS RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DME78MS RU https://pubmed.ncbi.nlm.nih.gov/17139284 DME78MS DI DME78MS DME78MS DN O2-Sulfo-Glucuronic Acid DME78MS MI TT4V2JM DME78MS MN Hepatocyte growth factor (HGF) DME78MS MT DTT DME78MS MA Inhibitor DME78MS RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DME78MS RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMKMH2X DI DMKMH2X DMKMH2X DN O5-Acetyl-O7-nitrooxyethyl chrysin DMKMH2X MI TTFBNVI DMKMH2X MN Aldose reductase (AKR1B1) DMKMH2X MT DTT DMKMH2X MA Inhibitor DMKMH2X RN Synthesis, characterization and vasculoprotective effects of nitric oxide-donating derivatives of chrysin. Bioorg Med Chem. 2010 May 1;18(9):3020-5. DMKMH2X RU https://pubmed.ncbi.nlm.nih.gov/20395149 DMAUDCW DI DMAUDCW DMAUDCW DN O7-Nitrooxyethyl chrysin DMAUDCW MI TTFBNVI DMAUDCW MN Aldose reductase (AKR1B1) DMAUDCW MT DTT DMAUDCW MA Inhibitor DMAUDCW RN Synthesis, characterization and vasculoprotective effects of nitric oxide-donating derivatives of chrysin. Bioorg Med Chem. 2010 May 1;18(9):3020-5. DMAUDCW RU https://pubmed.ncbi.nlm.nih.gov/20395149 DM458IH DI DM458IH DM458IH DN OAADPR DM458IH MI TTEBMN7 DM458IH MN Long transient receptor potential channel 2 (TRPM2) DM458IH MT DTT DM458IH MA Activator DM458IH RN Metabolite of SIR2 reaction modulates TRPM2 ion channel. J Biol Chem. 2006 May 19;281(20):14057-65. DM458IH RU https://pubmed.ncbi.nlm.nih.gov/16565078 DMAEHFT DI DMAEHFT DMAEHFT DN O-Acetylserine DMAEHFT MI TT8NGED DMAEHFT MN Prostaglandin G/H synthase 1 (COX-1) DMAEHFT MT DTT DMAEHFT MA Inhibitor DMAEHFT RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMAEHFT RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMOP8IJ DI DMOP8IJ DMOP8IJ DN OAG DMOP8IJ MI TTSJ9E7 DMOP8IJ MN Short transient receptor potential channel 2 (TRPC2) DMOP8IJ MT DTT DMOP8IJ MA Activator DMOP8IJ RN A diacylglycerol-gated cation channel in vomeronasal neuron dendrites is impaired in TRPC2 mutant mice: mechanism of pheromone transduction. Neuron. 2003 Oct 30;40(3):551-61. DMOP8IJ RU https://pubmed.ncbi.nlm.nih.gov/14642279 DMOP8IJ DI DMOP8IJ DMOP8IJ DN OAG DMOP8IJ MI TTNVC34 DMOP8IJ MN Short transient receptor potential channel 3 (TRPC3) DMOP8IJ MT DTT DMOP8IJ MA Activator DMOP8IJ RN Direct activation of human TRPC6 and TRPC3 channels by diacylglycerol. Nature. 1999 Jan 21;397(6716):259-63. DMOP8IJ RU https://pubmed.ncbi.nlm.nih.gov/9930701 DMOP8IJ DI DMOP8IJ DMOP8IJ DN OAG DMOP8IJ MI TTRBT3W DMOP8IJ MN Short transient receptor potential channel 6 (TRPC6) DMOP8IJ MT DTT DMOP8IJ MA Activator DMOP8IJ RN Direct activation of human TRPC6 and TRPC3 channels by diacylglycerol. Nature. 1999 Jan 21;397(6716):259-63. DMOP8IJ RU https://pubmed.ncbi.nlm.nih.gov/9930701 DMOP8IJ DI DMOP8IJ DMOP8IJ DN OAG DMOP8IJ MI TT06GRA DMOP8IJ MN Short transient receptor potential channel 7 (TRPC7) DMOP8IJ MT DTT DMOP8IJ MA Activator DMOP8IJ RN Molecular and functional characterization of a novel mouse transient receptor potential protein homologue TRP7. Ca(2+)-permeable cation channel that is constitutively activated and enhanced by stimulation of G protein-coupled receptor. J Biol Chem. 1999 Sep 24;274(39):27359-70. DMOP8IJ RU https://pubmed.ncbi.nlm.nih.gov/10488066 DML0P72 DI DML0P72 DML0P72 DN O-arachidonoyl ethanolamine DML0P72 MI TTNET8J DML0P72 MN G-protein coupled receptor 55 (GPR55) DML0P72 MT DTT DML0P72 MA Agonist DML0P72 RN The orphan receptor GPR55 is a novel cannabinoid receptor. Br J Pharmacol. 2007 Dec;152(7):1092-101. DML0P72 RU https://pubmed.ncbi.nlm.nih.gov/17876302 DMWZXH6 DI DMWZXH6 DMWZXH6 DN O-arachidonoyl-N-(2-hydroxyethyl)hydroxylamine DMWZXH6 MI TT6OEDT DMWZXH6 MN Cannabinoid receptor 1 (CB1) DMWZXH6 MT DTT DMWZXH6 MA Inhibitor DMWZXH6 RN Oxyhomologues of anandamide and related endolipids: chemoselective synthesis and biological activity. J Med Chem. 2006 Apr 6;49(7):2333-8. DMWZXH6 RU https://pubmed.ncbi.nlm.nih.gov/16570929 DMWZXH6 DI DMWZXH6 DMWZXH6 DN O-arachidonoyl-N-(2-hydroxyethyl)hydroxylamine DMWZXH6 MI TTMSFAW DMWZXH6 MN Cannabinoid receptor 2 (CB2) DMWZXH6 MT DTT DMWZXH6 MA Inhibitor DMWZXH6 RN Oxyhomologues of anandamide and related endolipids: chemoselective synthesis and biological activity. J Med Chem. 2006 Apr 6;49(7):2333-8. DMWZXH6 RU https://pubmed.ncbi.nlm.nih.gov/16570929 DMY4PMN DI DMY4PMN DMY4PMN DN OBABERINE DMY4PMN MI TTVBI8W DMY4PMN MN Dopamine transporter (DAT) DMY4PMN MT DTT DMY4PMN MA Inhibitor DMY4PMN RN Effects of various isoquinoline alkaloids on in vitro 3H-dopamine uptake by rat striatal synaptosomes. J Nat Prod. 1995 Oct;58(10):1475-84. DMY4PMN RU https://pubmed.ncbi.nlm.nih.gov/8676127 DMD25HJ DI DMD25HJ DMD25HJ DN O-Benzylsulfonyl-Serine DMD25HJ MI TT5DOVB DMD25HJ MN Cytomegalovirus Protease (CMV UL80) DMD25HJ MT DTT DMD25HJ MA Inhibitor DMD25HJ RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMD25HJ RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMM98BC DI DMM98BC DMM98BC DN OBIDOXIME DMM98BC MI TT1RS9F DMM98BC MN Acetylcholinesterase (AChE) DMM98BC MT DTT DMM98BC MA Inhibitor DMM98BC RN Synthesis of the novel series of bispyridinium compounds bearing (E)-but-2-ene linker and evaluation of their reactivation activity against chlorpy... Bioorg Med Chem Lett. 2006 Feb;16(3):622-7. DMM98BC RU https://pubmed.ncbi.nlm.nih.gov/16288867 DMA63FQ DI DMA63FQ DMA63FQ DN Obtusifoldienol DMA63FQ MI DEVSF75 DMA63FQ MN Cytochrome P450 monooxygenase 51A (cyp51A) DMA63FQ MT DME DMA63FQ MA Metabolism DMA63FQ RN nan DMA63FQ RU nan DMGVDR6 DI DMGVDR6 DMGVDR6 DN Ochnaflavone DMGVDR6 MI TTO8QRU DMGVDR6 MN Group IIA phospholipase A2 (GIIA sPLA2) DMGVDR6 MT DTT DMGVDR6 MA Inhibitor DMGVDR6 RN Synthesis of phospholipase A2 inhibitory biflavonoids. Bioorg Med Chem Lett. 2006 May 1;16(9):2373-5. DMGVDR6 RU https://pubmed.ncbi.nlm.nih.gov/16504502 DM69O3S DI DM69O3S DM69O3S DN OCID-2987 DM69O3S MI TTZ97H5 DM69O3S MN Phosphodiesterase 4A (PDE4A) DM69O3S MT DTT DM69O3S MA Inhibitor DM69O3S RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1300). DM69O3S RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1300 DM69O3S DI DM69O3S DM69O3S DN OCID-2987 DM69O3S MI TTVIAT9 DM69O3S MN Phosphodiesterase 4B (PDE4B) DM69O3S MT DTT DM69O3S MA Inhibitor DM69O3S RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1301). DM69O3S RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1301 DM69O3S DI DM69O3S DM69O3S DN OCID-2987 DM69O3S MI TTSKMI8 DM69O3S MN Phosphodiesterase 4D (PDE4D) DM69O3S MT DTT DM69O3S MA Inhibitor DM69O3S RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1303). DM69O3S RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1303 DMT59UG DI DMT59UG DMT59UG DN OCOPHYLLALS A DMT59UG MI TTVKILB DMT59UG MN Prostaglandin G/H synthase 2 (COX-2) DMT59UG MT DTT DMT59UG MA Inhibitor DMT59UG RN COX, LOX and platelet aggregation inhibitory properties of Lauraceae neolignans. Bioorg Med Chem Lett. 2009 Dec 15;19(24):6922-5. DMT59UG RU https://pubmed.ncbi.nlm.nih.gov/19880317 DMEUPVF DI DMEUPVF DMEUPVF DN Ocophyllals b DMEUPVF MI TTVKILB DMEUPVF MN Prostaglandin G/H synthase 2 (COX-2) DMEUPVF MT DTT DMEUPVF MA Inhibitor DMEUPVF RN COX, LOX and platelet aggregation inhibitory properties of Lauraceae neolignans. Bioorg Med Chem Lett. 2009 Dec 15;19(24):6922-5. DMEUPVF RU https://pubmed.ncbi.nlm.nih.gov/19880317 DMUFDR6 DI DMUFDR6 DMUFDR6 DN Octahydrocurcumin DMUFDR6 MI TTCJUR4 DMUFDR6 MN Exportin-1 (XPO1) DMUFDR6 MT DTT DMUFDR6 MA Inhibitor DMUFDR6 RN Therapeutic strategies targeting FOXO transcription factors. Nat Rev Drug Discov. 2021 Jan;20(1):21-38. DMUFDR6 RU https://pubmed.ncbi.nlm.nih.gov/33173189 DM4C70S DI DM4C70S DM4C70S DN Octahydro-isoindol-(1Z)-ylideneamine DM4C70S MI TTZUFI5 DM4C70S MN Nitric-oxide synthase brain (NOS1) DM4C70S MT DTT DM4C70S MA Inhibitor DM4C70S RN Evaluation of pyrrolidin-2-imines and 1,3-thiazolidin-2-imines as inhibitors of nitric oxide synthase. Bioorg Med Chem Lett. 2004 Sep 6;14(17):4539-44. DM4C70S RU https://pubmed.ncbi.nlm.nih.gov/15357988 DM4C70S DI DM4C70S DM4C70S DN Octahydro-isoindol-(1Z)-ylideneamine DM4C70S MI TTF10I9 DM4C70S MN Nitric-oxide synthase inducible (NOS2) DM4C70S MT DTT DM4C70S MA Inhibitor DM4C70S RN Evaluation of pyrrolidin-2-imines and 1,3-thiazolidin-2-imines as inhibitors of nitric oxide synthase. Bioorg Med Chem Lett. 2004 Sep 6;14(17):4539-44. DM4C70S RU https://pubmed.ncbi.nlm.nih.gov/15357988 DMTN0OK DI DMTN0OK DMTN0OK DN Octanal DMTN0OK MI DEM1HNL DMTN0OK MN Alcohol dehydrogenase class-I gamma (ADH1C) DMTN0OK MT DME DMTN0OK MA Metabolism DMTN0OK RN Oxidation of alcohols and reduction of aldehydes derived from methyl- and dimethylpyrenes by cDNA-expressed human alcohol dehydrogenases. Toxicology. 2008 Mar 12;245(1-2):65-75. DMTN0OK RU https://www.ncbi.nlm.nih.gov/pubmed/?term=18242813 DMTN0OK DI DMTN0OK DMTN0OK DN Octanal DMTN0OK MI DEOCWU3 DMTN0OK MN Alcohol dehydrogenase class-II (ADH4) DMTN0OK MT DME DMTN0OK MA Metabolism DMTN0OK RN Oxidation of alcohols and reduction of aldehydes derived from methyl- and dimethylpyrenes by cDNA-expressed human alcohol dehydrogenases. Toxicology. 2008 Mar 12;245(1-2):65-75. DMTN0OK RU https://www.ncbi.nlm.nih.gov/pubmed/?term=18242813 DMBQMGH DI DMBQMGH DMBQMGH DN Octane-1,8-diyl disulfamate DMBQMGH MI TTUNARX DMBQMGH MN Carbonic anhydrase (CA) DMBQMGH MT DTT DMBQMGH MA Inhibitor DMBQMGH RN Carbonic anhydrase inhibitors. Comparison of aliphatic sulfamate/bis-sulfamate adducts with isozymes II and IX as a platform for designing tight-bi... J Med Chem. 2009 Oct 8;52(19):5990-8. DMBQMGH RU https://pubmed.ncbi.nlm.nih.gov/19731956 DMBQMGH DI DMBQMGH DMBQMGH DN Octane-1,8-diyl disulfamate DMBQMGH MI TTHQPL7 DMBQMGH MN Carbonic anhydrase I (CA-I) DMBQMGH MT DTT DMBQMGH MA Inhibitor DMBQMGH RN Carbonic anhydrase inhibitors. Comparison of aliphatic sulfamate/bis-sulfamate adducts with isozymes II and IX as a platform for designing tight-bi... J Med Chem. 2009 Oct 8;52(19):5990-8. DMBQMGH RU https://pubmed.ncbi.nlm.nih.gov/19731956 DMBQMGH DI DMBQMGH DMBQMGH DN Octane-1,8-diyl disulfamate DMBQMGH MI TTANPDJ DMBQMGH MN Carbonic anhydrase II (CA-II) DMBQMGH MT DTT DMBQMGH MA Inhibitor DMBQMGH RN Carbonic anhydrase inhibitors. Comparison of aliphatic sulfamate/bis-sulfamate adducts with isozymes II and IX as a platform for designing tight-bi... J Med Chem. 2009 Oct 8;52(19):5990-8. DMBQMGH RU https://pubmed.ncbi.nlm.nih.gov/19731956 DMBQMGH DI DMBQMGH DMBQMGH DN Octane-1,8-diyl disulfamate DMBQMGH MI TTZHA0O DMBQMGH MN Carbonic anhydrase IV (CA-IV) DMBQMGH MT DTT DMBQMGH MA Inhibitor DMBQMGH RN Carbonic anhydrase inhibitors. Comparison of aliphatic sulfamate/bis-sulfamate adducts with isozymes II and IX as a platform for designing tight-bi... J Med Chem. 2009 Oct 8;52(19):5990-8. DMBQMGH RU https://pubmed.ncbi.nlm.nih.gov/19731956 DMBQMGH DI DMBQMGH DMBQMGH DN Octane-1,8-diyl disulfamate DMBQMGH MI TT2LVK8 DMBQMGH MN Carbonic anhydrase IX (CA-IX) DMBQMGH MT DTT DMBQMGH MA Inhibitor DMBQMGH RN Carbonic anhydrase inhibitors. Comparison of aliphatic sulfamate/bis-sulfamate adducts with isozymes II and IX as a platform for designing tight-bi... J Med Chem. 2009 Oct 8;52(19):5990-8. DMBQMGH RU https://pubmed.ncbi.nlm.nih.gov/19731956 DMBQMGH DI DMBQMGH DMBQMGH DN Octane-1,8-diyl disulfamate DMBQMGH MI TTCFSPE DMBQMGH MN Carbonic anhydrase VI (CA-VI) DMBQMGH MT DTT DMBQMGH MA Inhibitor DMBQMGH RN Carbonic anhydrase inhibitors. Comparison of aliphatic sulfamate/bis-sulfamate adducts with isozymes II and IX as a platform for designing tight-bi... J Med Chem. 2009 Oct 8;52(19):5990-8. DMBQMGH RU https://pubmed.ncbi.nlm.nih.gov/19731956 DMBQMGH DI DMBQMGH DMBQMGH DN Octane-1,8-diyl disulfamate DMBQMGH MI TTSYM0R DMBQMGH MN Carbonic anhydrase XII (CA-XII) DMBQMGH MT DTT DMBQMGH MA Inhibitor DMBQMGH RN Carbonic anhydrase inhibitors. Comparison of aliphatic sulfamate/bis-sulfamate adducts with isozymes II and IX as a platform for designing tight-bi... J Med Chem. 2009 Oct 8;52(19):5990-8. DMBQMGH RU https://pubmed.ncbi.nlm.nih.gov/19731956 DMBQMGH DI DMBQMGH DMBQMGH DN Octane-1,8-diyl disulfamate DMBQMGH MI TTEYTKG DMBQMGH MN Carbonic anhydrase XIV (CA-XIV) DMBQMGH MT DTT DMBQMGH MA Inhibitor DMBQMGH RN Carbonic anhydrase inhibitors. Comparison of aliphatic sulfamate/bis-sulfamate adducts with isozymes II and IX as a platform for designing tight-bi... J Med Chem. 2009 Oct 8;52(19):5990-8. DMBQMGH RU https://pubmed.ncbi.nlm.nih.gov/19731956 DMDBI5S DI DMDBI5S DMDBI5S DN Octane-1-sulfonyl fluoride DMDBI5S MI TT6OEDT DMDBI5S MN Cannabinoid receptor 1 (CB1) DMDBI5S MT DTT DMDBI5S MA Inhibitor DMDBI5S RN Monoacylglycerol lipase regulates 2-arachidonoylglycerol action and arachidonic acid levels. Bioorg Med Chem Lett. 2008 Nov 15;18(22):5875-8. DMDBI5S RU https://pubmed.ncbi.nlm.nih.gov/18752948 DMDBI5S DI DMDBI5S DMDBI5S DN Octane-1-sulfonyl fluoride DMDBI5S MI TTDP1UC DMDBI5S MN Fatty acid amide hydrolase (FAAH) DMDBI5S MT DTT DMDBI5S MA Inhibitor DMDBI5S RN Monoacylglycerol lipase regulates 2-arachidonoylglycerol action and arachidonic acid levels. Bioorg Med Chem Lett. 2008 Nov 15;18(22):5875-8. DMDBI5S RU https://pubmed.ncbi.nlm.nih.gov/18752948 DMJNQ9K DI DMJNQ9K DMJNQ9K DN Octanedioic acid bis-hydroxyamide DMJNQ9K MI TTBH0VX DMJNQ9K MN Histone deacetylase (HDAC) DMJNQ9K MT DTT DMJNQ9K MA Inhibitor DMJNQ9K RN Chemical phylogenetics of histone deacetylases. Nat Chem Biol. 2010 Mar;6(3):238-243. DMJNQ9K RU https://pubmed.ncbi.nlm.nih.gov/20139990 DMJNQ9K DI DMJNQ9K DMJNQ9K DN Octanedioic acid bis-hydroxyamide DMJNQ9K MI TT6R7JZ DMJNQ9K MN Histone deacetylase 1 (HDAC1) DMJNQ9K MT DTT DMJNQ9K MA Inhibitor DMJNQ9K RN Structure-activity relationships on phenylalanine-containing inhibitors of histone deacetylase: in vitro enzyme inhibition, induction of differenti... J Med Chem. 2002 Jul 18;45(15):3296-309. DMJNQ9K RU https://pubmed.ncbi.nlm.nih.gov/12109913 DMJNQ9K DI DMJNQ9K DMJNQ9K DN Octanedioic acid bis-hydroxyamide DMJNQ9K MI TTSHTOI DMJNQ9K MN Histone deacetylase 2 (HDAC2) DMJNQ9K MT DTT DMJNQ9K MA Inhibitor DMJNQ9K RN Structure-activity relationships on phenylalanine-containing inhibitors of histone deacetylase: in vitro enzyme inhibition, induction of differenti... J Med Chem. 2002 Jul 18;45(15):3296-309. DMJNQ9K RU https://pubmed.ncbi.nlm.nih.gov/12109913 DMJNQ9K DI DMJNQ9K DMJNQ9K DN Octanedioic acid bis-hydroxyamide DMJNQ9K MI TTTQGH8 DMJNQ9K MN Histone deacetylase 4 (HDAC4) DMJNQ9K MT DTT DMJNQ9K MA Inhibitor DMJNQ9K RN Structure-activity relationships on phenylalanine-containing inhibitors of histone deacetylase: in vitro enzyme inhibition, induction of differenti... J Med Chem. 2002 Jul 18;45(15):3296-309. DMJNQ9K RU https://pubmed.ncbi.nlm.nih.gov/12109913 DMJNQ9K DI DMJNQ9K DMJNQ9K DN Octanedioic acid bis-hydroxyamide DMJNQ9K MI TT5ZKDI DMJNQ9K MN Histone deacetylase 6 (HDAC6) DMJNQ9K MT DTT DMJNQ9K MA Inhibitor DMJNQ9K RN Structure-activity relationships on phenylalanine-containing inhibitors of histone deacetylase: in vitro enzyme inhibition, induction of differenti... J Med Chem. 2002 Jul 18;45(15):3296-309. DMJNQ9K RU https://pubmed.ncbi.nlm.nih.gov/12109913 DMJNQ9K DI DMJNQ9K DMJNQ9K DN Octanedioic acid bis-hydroxyamide DMJNQ9K MI TTT6LFV DMJNQ9K MN Histone deacetylase 8 (HDAC8) DMJNQ9K MT DTT DMJNQ9K MA Inhibitor DMJNQ9K RN Chemical phylogenetics of histone deacetylases. Nat Chem Biol. 2010 Mar;6(3):238-243. DMJNQ9K RU https://pubmed.ncbi.nlm.nih.gov/20139990 DMHNWS1 DI DMHNWS1 DMHNWS1 DN Octanedioic acid hydroxyamide pyridin-2-ylamide DMHNWS1 MI TTBH0VX DMHNWS1 MN Histone deacetylase (HDAC) DMHNWS1 MT DTT DMHNWS1 MA Inhibitor DMHNWS1 RN Inhibitors of human histone deacetylase: synthesis and enzyme and cellular activity of straight chain hydroxamates. J Med Chem. 2002 Feb 14;45(4):753-7. DMHNWS1 RU https://pubmed.ncbi.nlm.nih.gov/11831887 DMHNWS1 DI DMHNWS1 DMHNWS1 DN Octanedioic acid hydroxyamide pyridin-2-ylamide DMHNWS1 MI TT6R7JZ DMHNWS1 MN Histone deacetylase 1 (HDAC1) DMHNWS1 MT DTT DMHNWS1 MA Inhibitor DMHNWS1 RN Inhibitors of human histone deacetylase: synthesis and enzyme and cellular activity of straight chain hydroxamates. J Med Chem. 2002 Feb 14;45(4):753-7. DMHNWS1 RU https://pubmed.ncbi.nlm.nih.gov/11831887 DMHNWS1 DI DMHNWS1 DMHNWS1 DN Octanedioic acid hydroxyamide pyridin-2-ylamide DMHNWS1 MI TTYHPU6 DMHNWS1 MN Histone deacetylase 10 (HDAC10) DMHNWS1 MT DTT DMHNWS1 MA Inhibitor DMHNWS1 RN Inhibitors of human histone deacetylase: synthesis and enzyme and cellular activity of straight chain hydroxamates. J Med Chem. 2002 Feb 14;45(4):753-7. DMHNWS1 RU https://pubmed.ncbi.nlm.nih.gov/11831887 DMHNWS1 DI DMHNWS1 DMHNWS1 DN Octanedioic acid hydroxyamide pyridin-2-ylamide DMHNWS1 MI TTSHTOI DMHNWS1 MN Histone deacetylase 2 (HDAC2) DMHNWS1 MT DTT DMHNWS1 MA Inhibitor DMHNWS1 RN Inhibitors of human histone deacetylase: synthesis and enzyme and cellular activity of straight chain hydroxamates. J Med Chem. 2002 Feb 14;45(4):753-7. DMHNWS1 RU https://pubmed.ncbi.nlm.nih.gov/11831887 DMHNWS1 DI DMHNWS1 DMHNWS1 DN Octanedioic acid hydroxyamide pyridin-2-ylamide DMHNWS1 MI TTTQGH8 DMHNWS1 MN Histone deacetylase 4 (HDAC4) DMHNWS1 MT DTT DMHNWS1 MA Inhibitor DMHNWS1 RN Inhibitors of human histone deacetylase: synthesis and enzyme and cellular activity of straight chain hydroxamates. J Med Chem. 2002 Feb 14;45(4):753-7. DMHNWS1 RU https://pubmed.ncbi.nlm.nih.gov/11831887 DMHNWS1 DI DMHNWS1 DMHNWS1 DN Octanedioic acid hydroxyamide pyridin-2-ylamide DMHNWS1 MI TT5ZKDI DMHNWS1 MN Histone deacetylase 6 (HDAC6) DMHNWS1 MT DTT DMHNWS1 MA Inhibitor DMHNWS1 RN Inhibitors of human histone deacetylase: synthesis and enzyme and cellular activity of straight chain hydroxamates. J Med Chem. 2002 Feb 14;45(4):753-7. DMHNWS1 RU https://pubmed.ncbi.nlm.nih.gov/11831887 DMHNWS1 DI DMHNWS1 DMHNWS1 DN Octanedioic acid hydroxyamide pyridin-2-ylamide DMHNWS1 MI TTT6LFV DMHNWS1 MN Histone deacetylase 8 (HDAC8) DMHNWS1 MT DTT DMHNWS1 MA Inhibitor DMHNWS1 RN Inhibitors of human histone deacetylase: synthesis and enzyme and cellular activity of straight chain hydroxamates. J Med Chem. 2002 Feb 14;45(4):753-7. DMHNWS1 RU https://pubmed.ncbi.nlm.nih.gov/11831887 DM945RK DI DM945RK DM945RK DN Octanedioic acid hydroxyamide pyridin-4-ylamide DM945RK MI TTBH0VX DM945RK MN Histone deacetylase (HDAC) DM945RK MT DTT DM945RK MA Inhibitor DM945RK RN Inhibitors of human histone deacetylase: synthesis and enzyme and cellular activity of straight chain hydroxamates. J Med Chem. 2002 Feb 14;45(4):753-7. DM945RK RU https://pubmed.ncbi.nlm.nih.gov/11831887 DM945RK DI DM945RK DM945RK DN Octanedioic acid hydroxyamide pyridin-4-ylamide DM945RK MI TT6R7JZ DM945RK MN Histone deacetylase 1 (HDAC1) DM945RK MT DTT DM945RK MA Inhibitor DM945RK RN Inhibitors of human histone deacetylase: synthesis and enzyme and cellular activity of straight chain hydroxamates. J Med Chem. 2002 Feb 14;45(4):753-7. DM945RK RU https://pubmed.ncbi.nlm.nih.gov/11831887 DM945RK DI DM945RK DM945RK DN Octanedioic acid hydroxyamide pyridin-4-ylamide DM945RK MI TTYHPU6 DM945RK MN Histone deacetylase 10 (HDAC10) DM945RK MT DTT DM945RK MA Inhibitor DM945RK RN Inhibitors of human histone deacetylase: synthesis and enzyme and cellular activity of straight chain hydroxamates. J Med Chem. 2002 Feb 14;45(4):753-7. DM945RK RU https://pubmed.ncbi.nlm.nih.gov/11831887 DM945RK DI DM945RK DM945RK DN Octanedioic acid hydroxyamide pyridin-4-ylamide DM945RK MI TTSHTOI DM945RK MN Histone deacetylase 2 (HDAC2) DM945RK MT DTT DM945RK MA Inhibitor DM945RK RN Inhibitors of human histone deacetylase: synthesis and enzyme and cellular activity of straight chain hydroxamates. J Med Chem. 2002 Feb 14;45(4):753-7. DM945RK RU https://pubmed.ncbi.nlm.nih.gov/11831887 DM945RK DI DM945RK DM945RK DN Octanedioic acid hydroxyamide pyridin-4-ylamide DM945RK MI TTTQGH8 DM945RK MN Histone deacetylase 4 (HDAC4) DM945RK MT DTT DM945RK MA Inhibitor DM945RK RN Inhibitors of human histone deacetylase: synthesis and enzyme and cellular activity of straight chain hydroxamates. J Med Chem. 2002 Feb 14;45(4):753-7. DM945RK RU https://pubmed.ncbi.nlm.nih.gov/11831887 DM945RK DI DM945RK DM945RK DN Octanedioic acid hydroxyamide pyridin-4-ylamide DM945RK MI TT5ZKDI DM945RK MN Histone deacetylase 6 (HDAC6) DM945RK MT DTT DM945RK MA Inhibitor DM945RK RN Inhibitors of human histone deacetylase: synthesis and enzyme and cellular activity of straight chain hydroxamates. J Med Chem. 2002 Feb 14;45(4):753-7. DM945RK RU https://pubmed.ncbi.nlm.nih.gov/11831887 DM945RK DI DM945RK DM945RK DN Octanedioic acid hydroxyamide pyridin-4-ylamide DM945RK MI TTT6LFV DM945RK MN Histone deacetylase 8 (HDAC8) DM945RK MT DTT DM945RK MA Inhibitor DM945RK RN Inhibitors of human histone deacetylase: synthesis and enzyme and cellular activity of straight chain hydroxamates. J Med Chem. 2002 Feb 14;45(4):753-7. DM945RK RU https://pubmed.ncbi.nlm.nih.gov/11831887 DM4RGCX DI DM4RGCX DM4RGCX DN Octanoic acid biphenyl-2-ylamide DM4RGCX MI TTK3C21 DM4RGCX MN Acetoacetyl-CoA thiolase (ACAT1) DM4RGCX MT DTT DM4RGCX MA Inhibitor DM4RGCX RN Biphenyl versus phenylpyridazine derivatives: the role of the heterocycle in a series of acyl-CoA:cholesterol acyl transferase inhibitors. J Med Chem. 2008 Mar 13;51(5):1474-7. DM4RGCX RU https://pubmed.ncbi.nlm.nih.gov/18284184 DMBGHPE DI DMBGHPE DMBGHPE DN Octanol DMBGHPE MI DEM1HNL DMBGHPE MN Alcohol dehydrogenase class-I gamma (ADH1C) DMBGHPE MT DME DMBGHPE MA Metabolism DMBGHPE RN Oxidation of alcohols and reduction of aldehydes derived from methyl- and dimethylpyrenes by cDNA-expressed human alcohol dehydrogenases. Toxicology. 2008 Mar 12;245(1-2):65-75. DMBGHPE RU https://www.ncbi.nlm.nih.gov/pubmed/?term=18242813 DMBGHPE DI DMBGHPE DMBGHPE DN Octanol DMBGHPE MI DEOCWU3 DMBGHPE MN Alcohol dehydrogenase class-II (ADH4) DMBGHPE MT DME DMBGHPE MA Metabolism DMBGHPE RN Oxidation of alcohols and reduction of aldehydes derived from methyl- and dimethylpyrenes by cDNA-expressed human alcohol dehydrogenases. Toxicology. 2008 Mar 12;245(1-2):65-75. DMBGHPE RU https://www.ncbi.nlm.nih.gov/pubmed/?term=18242813 DMBGHPE DI DMBGHPE DMBGHPE DN Octanol DMBGHPE MI TTDQPXA DMBGHPE MN Connexin-23 (Cx23) DMBGHPE MT DTT DMBGHPE MA Inhibitor DMBGHPE RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 714). DMBGHPE RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=714 DMBGHPE DI DMBGHPE DMBGHPE DN Octanol DMBGHPE MI TTZ7POK DMBGHPE MN Connexin-25 (Cx25) DMBGHPE MT DTT DMBGHPE MA Inhibitor DMBGHPE RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 715). DMBGHPE RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=715 DMBGHPE DI DMBGHPE DMBGHPE DN Octanol DMBGHPE MI TTAU8SJ DMBGHPE MN Connexin-30 (Cx30) DMBGHPE MT DTT DMBGHPE MA Inhibitor DMBGHPE RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 717). DMBGHPE RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=717 DMBGHPE DI DMBGHPE DMBGHPE DN Octanol DMBGHPE MI TTHWA40 DMBGHPE MN Connexin-32 (Cx32) DMBGHPE MT DTT DMBGHPE MA Inhibitor DMBGHPE RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 723). DMBGHPE RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=723 DMBGHPE DI DMBGHPE DMBGHPE DN Octanol DMBGHPE MI TTEP7OC DMBGHPE MN Connexin-45 (Cx45) DMBGHPE MT DTT DMBGHPE MA Inhibitor DMBGHPE RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 729). DMBGHPE RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=729 DMBGHPE DI DMBGHPE DMBGHPE DN Octanol DMBGHPE MI TTYP9NL DMBGHPE MN Connexin-59 (Cx59) DMBGHPE MT DTT DMBGHPE MA Inhibitor DMBGHPE RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 733). DMBGHPE RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=733 DMBGHPE DI DMBGHPE DMBGHPE DN Octanol DMBGHPE MI TTQMI2N DMBGHPE MN Connexin-62 (Cx62) DMBGHPE MT DTT DMBGHPE MA Inhibitor DMBGHPE RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 734). DMBGHPE RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=734 DMBGHPE DI DMBGHPE DMBGHPE DN Octanol DMBGHPE MI TT4F7SL DMBGHPE MN Gap junction alpha-1 protein (GJA1) DMBGHPE MT DTT DMBGHPE MA Inhibitor DMBGHPE RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 728). DMBGHPE RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=728 DMBGHPE DI DMBGHPE DMBGHPE DN Octanol DMBGHPE MI TTFZRG0 DMBGHPE MN Gap junction alpha-3 protein (Cx46) DMBGHPE MT DTT DMBGHPE MA Inhibitor DMBGHPE RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 730). DMBGHPE RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=730 DMBGHPE DI DMBGHPE DMBGHPE DN Octanol DMBGHPE MI TTQO1VY DMBGHPE MN Gap junction alpha-4 protein (Cx37) DMBGHPE MT DTT DMBGHPE MA Inhibitor DMBGHPE RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 725). DMBGHPE RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=725 DMBGHPE DI DMBGHPE DMBGHPE DN Octanol DMBGHPE MI TTFQKZ7 DMBGHPE MN Gap junction alpha-5 protein (Cx40) DMBGHPE MT DTT DMBGHPE MA Inhibitor DMBGHPE RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 726). DMBGHPE RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=726 DMBGHPE DI DMBGHPE DMBGHPE DN Octanol DMBGHPE MI TTJ7ATH DMBGHPE MN Gap junction alpha-8 protein (Cx50) DMBGHPE MT DTT DMBGHPE MA Inhibitor DMBGHPE RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 732). DMBGHPE RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=732 DMBGHPE DI DMBGHPE DMBGHPE DN Octanol DMBGHPE MI TTRGZX3 DMBGHPE MN Gap junction beta-2 protein (Cx26) DMBGHPE MT DTT DMBGHPE MA Inhibitor DMBGHPE RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 716). DMBGHPE RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=716 DMBGHPE DI DMBGHPE DMBGHPE DN Octanol DMBGHPE MI TTVRQ8L DMBGHPE MN Gap junction beta-3 protein (Cx31) DMBGHPE MT DTT DMBGHPE MA Inhibitor DMBGHPE RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 720). DMBGHPE RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=720 DMBGHPE DI DMBGHPE DMBGHPE DN Octanol DMBGHPE MI TTBRDFI DMBGHPE MN Gap junction beta-4 protein (Cx30.3) DMBGHPE MT DTT DMBGHPE MA Inhibitor DMBGHPE RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 719). DMBGHPE RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=719 DMBGHPE DI DMBGHPE DMBGHPE DN Octanol DMBGHPE MI TTL9MHP DMBGHPE MN Gap junction beta-5 protein (Cx31.1) DMBGHPE MT DTT DMBGHPE MA Inhibitor DMBGHPE RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 721). DMBGHPE RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=721 DMBGHPE DI DMBGHPE DMBGHPE DN Octanol DMBGHPE MI TTOZAFI DMBGHPE MN Gap junction delta-2 protein (Cx36) DMBGHPE MT DTT DMBGHPE MA Inhibitor DMBGHPE RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 724). DMBGHPE RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=724 DMBGHPE DI DMBGHPE DMBGHPE DN Octanol DMBGHPE MI TT7C18W DMBGHPE MN Gap junction delta-3 protein (Cx31.9) DMBGHPE MT DTT DMBGHPE MA Inhibitor DMBGHPE RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 722). DMBGHPE RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=722 DMBGHPE DI DMBGHPE DMBGHPE DN Octanol DMBGHPE MI TTL07NQ DMBGHPE MN Gap junction delta-4 protein (Cx40.1) DMBGHPE MT DTT DMBGHPE MA Inhibitor DMBGHPE RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 727). DMBGHPE RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=727 DMBGHPE DI DMBGHPE DMBGHPE DN Octanol DMBGHPE MI TTPOCAL DMBGHPE MN Gap junction gamma-2 protein (Cx47) DMBGHPE MT DTT DMBGHPE MA Inhibitor DMBGHPE RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 731). DMBGHPE RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=731 DMBGHPE DI DMBGHPE DMBGHPE DN Octanol DMBGHPE MI TTUW608 DMBGHPE MN Gap junction gamma-3 protein (Cx30.2) DMBGHPE MT DTT DMBGHPE MA Inhibitor DMBGHPE RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 718). DMBGHPE RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=718 DM0UADK DI DM0UADK DM0UADK DN OCTOCLOTHEPIN DM0UADK MI TTWJBZ5 DM0UADK MN 5-HT 2C receptor (HTR2C) DM0UADK MT DTT DM0UADK MA Inhibitor DM0UADK RN Exploring the neuroleptic substituent in octoclothepin: potential ligands for positron emission tomography with subnanomolar affinity for (1)-adre... J Med Chem. 2010 Oct 14;53(19):7021-34. DM0UADK RU https://pubmed.ncbi.nlm.nih.gov/20857909 DM0UADK DI DM0UADK DM0UADK DN OCTOCLOTHEPIN DM0UADK MI TTJS8PY DM0UADK MN 5-HT 6 receptor (HTR6) DM0UADK MT DTT DM0UADK MA Inhibitor DM0UADK RN Medicinal chemistry driven approaches toward novel and selective serotonin 5-HT6 receptor ligands. J Med Chem. 2005 Mar 24;48(6):1781-95. DM0UADK RU https://pubmed.ncbi.nlm.nih.gov/15771424 DM0UADK DI DM0UADK DM0UADK DN OCTOCLOTHEPIN DM0UADK MI TTNGILX DM0UADK MN Adrenergic receptor alpha-1A (ADRA1A) DM0UADK MT DTT DM0UADK MA Inhibitor DM0UADK RN Exploring the neuroleptic substituent in octoclothepin: potential ligands for positron emission tomography with subnanomolar affinity for (1)-adre... J Med Chem. 2010 Oct 14;53(19):7021-34. DM0UADK RU https://pubmed.ncbi.nlm.nih.gov/20857909 DM0UADK DI DM0UADK DM0UADK DN OCTOCLOTHEPIN DM0UADK MI TTBRKXS DM0UADK MN Adrenergic receptor alpha-1B (ADRA1B) DM0UADK MT DTT DM0UADK MA Inhibitor DM0UADK RN Exploring the neuroleptic substituent in octoclothepin: potential ligands for positron emission tomography with subnanomolar affinity for (1)-adre... J Med Chem. 2010 Oct 14;53(19):7021-34. DM0UADK RU https://pubmed.ncbi.nlm.nih.gov/20857909 DM0UADK DI DM0UADK DM0UADK DN OCTOCLOTHEPIN DM0UADK MI TT34BHT DM0UADK MN Adrenergic receptor alpha-1D (ADRA1D) DM0UADK MT DTT DM0UADK MA Inhibitor DM0UADK RN Exploring the neuroleptic substituent in octoclothepin: potential ligands for positron emission tomography with subnanomolar affinity for (1)-adre... J Med Chem. 2010 Oct 14;53(19):7021-34. DM0UADK RU https://pubmed.ncbi.nlm.nih.gov/20857909 DM0UADK DI DM0UADK DM0UADK DN OCTOCLOTHEPIN DM0UADK MI TTEX248 DM0UADK MN Dopamine D2 receptor (D2R) DM0UADK MT DTT DM0UADK MA Inhibitor DM0UADK RN Exploring the neuroleptic substituent in octoclothepin: potential ligands for positron emission tomography with subnanomolar affinity for (1)-adre... J Med Chem. 2010 Oct 14;53(19):7021-34. DM0UADK RU https://pubmed.ncbi.nlm.nih.gov/20857909 DM0UADK DI DM0UADK DM0UADK DN OCTOCLOTHEPIN DM0UADK MI TTTIBOJ DM0UADK MN Histamine H1 receptor (H1R) DM0UADK MT DTT DM0UADK MA Inhibitor DM0UADK RN Exploring the neuroleptic substituent in octoclothepin: potential ligands for positron emission tomography with subnanomolar affinity for (1)-adre... J Med Chem. 2010 Oct 14;53(19):7021-34. DM0UADK RU https://pubmed.ncbi.nlm.nih.gov/20857909 DM40ZCA DI DM40ZCA DM40ZCA DN Octyl sulfamate DM40ZCA MI TTUNARX DM40ZCA MN Carbonic anhydrase (CA) DM40ZCA MT DTT DM40ZCA MA Inhibitor DM40ZCA RN Carbonic anhydrase inhibitors. Comparison of aliphatic sulfamate/bis-sulfamate adducts with isozymes II and IX as a platform for designing tight-bi... J Med Chem. 2009 Oct 8;52(19):5990-8. DM40ZCA RU https://pubmed.ncbi.nlm.nih.gov/19731956 DM40ZCA DI DM40ZCA DM40ZCA DN Octyl sulfamate DM40ZCA MI TTHQPL7 DM40ZCA MN Carbonic anhydrase I (CA-I) DM40ZCA MT DTT DM40ZCA MA Inhibitor DM40ZCA RN Carbonic anhydrase inhibitors. Comparison of aliphatic sulfamate/bis-sulfamate adducts with isozymes II and IX as a platform for designing tight-bi... J Med Chem. 2009 Oct 8;52(19):5990-8. DM40ZCA RU https://pubmed.ncbi.nlm.nih.gov/19731956 DM40ZCA DI DM40ZCA DM40ZCA DN Octyl sulfamate DM40ZCA MI TTANPDJ DM40ZCA MN Carbonic anhydrase II (CA-II) DM40ZCA MT DTT DM40ZCA MA Inhibitor DM40ZCA RN Carbonic anhydrase inhibitors. Comparison of aliphatic sulfamate/bis-sulfamate adducts with isozymes II and IX as a platform for designing tight-bi... J Med Chem. 2009 Oct 8;52(19):5990-8. DM40ZCA RU https://pubmed.ncbi.nlm.nih.gov/19731956 DM40ZCA DI DM40ZCA DM40ZCA DN Octyl sulfamate DM40ZCA MI TTZHA0O DM40ZCA MN Carbonic anhydrase IV (CA-IV) DM40ZCA MT DTT DM40ZCA MA Inhibitor DM40ZCA RN Carbonic anhydrase inhibitors. Comparison of aliphatic sulfamate/bis-sulfamate adducts with isozymes II and IX as a platform for designing tight-bi... J Med Chem. 2009 Oct 8;52(19):5990-8. DM40ZCA RU https://pubmed.ncbi.nlm.nih.gov/19731956 DM40ZCA DI DM40ZCA DM40ZCA DN Octyl sulfamate DM40ZCA MI TT2LVK8 DM40ZCA MN Carbonic anhydrase IX (CA-IX) DM40ZCA MT DTT DM40ZCA MA Inhibitor DM40ZCA RN Carbonic anhydrase inhibitors. Comparison of aliphatic sulfamate/bis-sulfamate adducts with isozymes II and IX as a platform for designing tight-bi... J Med Chem. 2009 Oct 8;52(19):5990-8. DM40ZCA RU https://pubmed.ncbi.nlm.nih.gov/19731956 DM40ZCA DI DM40ZCA DM40ZCA DN Octyl sulfamate DM40ZCA MI TTCFSPE DM40ZCA MN Carbonic anhydrase VI (CA-VI) DM40ZCA MT DTT DM40ZCA MA Inhibitor DM40ZCA RN Carbonic anhydrase inhibitors. Comparison of aliphatic sulfamate/bis-sulfamate adducts with isozymes II and IX as a platform for designing tight-bi... J Med Chem. 2009 Oct 8;52(19):5990-8. DM40ZCA RU https://pubmed.ncbi.nlm.nih.gov/19731956 DM40ZCA DI DM40ZCA DM40ZCA DN Octyl sulfamate DM40ZCA MI TTSYM0R DM40ZCA MN Carbonic anhydrase XII (CA-XII) DM40ZCA MT DTT DM40ZCA MA Inhibitor DM40ZCA RN Carbonic anhydrase inhibitors. Comparison of aliphatic sulfamate/bis-sulfamate adducts with isozymes II and IX as a platform for designing tight-bi... J Med Chem. 2009 Oct 8;52(19):5990-8. DM40ZCA RU https://pubmed.ncbi.nlm.nih.gov/19731956 DM40ZCA DI DM40ZCA DM40ZCA DN Octyl sulfamate DM40ZCA MI TTEYTKG DM40ZCA MN Carbonic anhydrase XIV (CA-XIV) DM40ZCA MT DTT DM40ZCA MA Inhibitor DM40ZCA RN Carbonic anhydrase inhibitors. Comparison of aliphatic sulfamate/bis-sulfamate adducts with isozymes II and IX as a platform for designing tight-bi... J Med Chem. 2009 Oct 8;52(19):5990-8. DM40ZCA RU https://pubmed.ncbi.nlm.nih.gov/19731956 DM2RJYO DI DM2RJYO DM2RJYO DN octyl thiophosphatidic acid DM2RJYO MI TTABCJ6 DM2RJYO MN Lysophosphatidic acid receptor 5 (LPAR5) DM2RJYO MT DTT DM2RJYO MA Agonist DM2RJYO RN Unique ligand selectivity of the GPR92/LPA5 lysophosphatidate receptor indicates role in human platelet activation. J Biol Chem. 2009 Jun 19;284(25):17304-19. DM2RJYO RU https://pubmed.ncbi.nlm.nih.gov/19366702 DMXLGUS DI DMXLGUS DMXLGUS DN OCTYL_GALLATE DMXLGUS MI TTE14XG DMXLGUS MN Squalene monooxygenase (SQLE) DMXLGUS MT DTT DMXLGUS MA Inhibitor DMXLGUS RN Ellagitannins and hexahydroxydiphenoyl esters as inhibitors of vertebrate squalene epoxidase. J Nat Prod. 2001 Aug;64(8):1010-4. DMXLGUS RU https://pubmed.ncbi.nlm.nih.gov/11520216 DM8ZG2I DI DM8ZG2I DM8ZG2I DN O-DESMETHYL TRAMADOL DM8ZG2I MI TT27RFC DM8ZG2I MN Opioid receptor delta (OPRD1) DM8ZG2I MT DTT DM8ZG2I MA Inhibitor DM8ZG2I RN Syntheses and opioid receptor binding properties of carboxamido-substituted opioids. Bioorg Med Chem Lett. 2009 Jan 1;19(1):203-8. DM8ZG2I RU https://pubmed.ncbi.nlm.nih.gov/19027293 DM8ZG2I DI DM8ZG2I DM8ZG2I DN O-DESMETHYL TRAMADOL DM8ZG2I MI TTQW87Y DM8ZG2I MN Opioid receptor kappa (OPRK1) DM8ZG2I MT DTT DM8ZG2I MA Inhibitor DM8ZG2I RN Syntheses and opioid receptor binding properties of carboxamido-substituted opioids. Bioorg Med Chem Lett. 2009 Jan 1;19(1):203-8. DM8ZG2I RU https://pubmed.ncbi.nlm.nih.gov/19027293 DM8ZG2I DI DM8ZG2I DM8ZG2I DN O-DESMETHYL TRAMADOL DM8ZG2I MI TTKWM86 DM8ZG2I MN Opioid receptor mu (MOP) DM8ZG2I MT DTT DM8ZG2I MA Inhibitor DM8ZG2I RN Syntheses and opioid receptor binding properties of carboxamido-substituted opioids. Bioorg Med Chem Lett. 2009 Jan 1;19(1):203-8. DM8ZG2I RU https://pubmed.ncbi.nlm.nih.gov/19027293 DM8ZG2I DI DM8ZG2I DM8ZG2I DN O-DESMETHYL TRAMADOL DM8ZG2I MI TT3ROYC DM8ZG2I MN Serotonin transporter (SERT) DM8ZG2I MT DTT DM8ZG2I MA Inhibitor DM8ZG2I RN Derivatives of tramadol for increased duration of effect. Bioorg Med Chem Lett. 2006 Feb;16(3):691-4. DM8ZG2I RU https://pubmed.ncbi.nlm.nih.gov/16257206 DM0GVZO DI DM0GVZO DM0GVZO DN ODN-1411 DM0GVZO MI TT8CWFK DM0GVZO MN Toll-like receptor 8 (TLR8) DM0GVZO MT DTT DM0GVZO MA Inhibitor DM0GVZO RN Oligodeoxynucleotide inhibition of Toll-like receptors 3, 7, 8, and 9 suppresses cytokine production in a human rheumatoid arthritis model. Eur J Immunol. 2016 Mar;46(3):772-81. DM0GVZO RU https://pubmed.ncbi.nlm.nih.gov/26593270 DM692XV DI DM692XV DM692XV DN ODN-2088 DM692XV MI TTSHG0T DM692XV MN Toll-like receptor 9 (TLR9) DM692XV MT DTT DM692XV MA Antagonist DM692XV RN Toll-like receptor 9 antagonism modulates astrocyte function and preserves proximal axons following spinal cord injury. Brain Behav Immun. 2019 Aug;80:328-343. DM692XV RU https://pubmed.ncbi.nlm.nih.gov/30953770 DMSAJO8 DI DMSAJO8 DMSAJO8 DN ODQ DMSAJO8 MI TTWNFC2 DMSAJO8 MN Soluble guanylyl cyclase (GUCY2D) DMSAJO8 MT DTT DMSAJO8 MA Inhibitor DMSAJO8 RN Potent and selective inhibition of nitric oxide-sensitive guanylyl cyclase by 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one. Mol Pharmacol. 1995 Aug;48(2):184-8. DMSAJO8 RU https://pubmed.ncbi.nlm.nih.gov/7544433 DMK8LEC DI DMK8LEC DMK8LEC DN OF-1 DMK8LEC MI TTT46BN DMK8LEC MN Bromodomain and PHD finger containing 1 (BRPF1) DMK8LEC MT DTT DMK8LEC MA Inhibitor DMK8LEC RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2730). DMK8LEC RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2730 DMK8LEC DI DMK8LEC DMK8LEC DN OF-1 DMK8LEC MI TTT09OB DMK8LEC MN Bromodomain-containing protein 1 (BRD1) DMK8LEC MT DTT DMK8LEC MA Inhibitor DMK8LEC RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2724). DMK8LEC RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2724 DM0PMKW DI DM0PMKW DM0PMKW DN OG-L002 DM0PMKW MI TTNR0UQ DM0PMKW MN Lysine-specific histone demethylase 1 (LSD) DM0PMKW MT DTT DM0PMKW MA Inhibitor DM0PMKW RN A novel selective LSD1/KDM1A inhibitor epigenetically blocks herpes simplex virus lytic replication and reactivation from latency. MBio. 2013 Feb 5;4(1):e00558-12. DM0PMKW RU https://pubmed.ncbi.nlm.nih.gov/23386436 DMXGA12 DI DMXGA12 DMXGA12 DN OGX-427 + Paclitaxel DMXGA12 MI TT9AZWY DMXGA12 MN HSPB1 messenger RNA (HSPB1 mRNA) DMXGA12 MT DTT DMXGA12 RN Design and development of antisense drugs. Expert Opin. Drug Discov. 2008 3(10):1189-1207. DMXGA12 RU http://www.informahealthcare.com/doi/abs/10.1517/17460441.3.10.1177 DMZMTLB DI DMZMTLB DMZMTLB DN OHIOENSIN A DMZMTLB MI TTELIN2 DMZMTLB MN PTPN1 messenger RNA (PTPN1 mRNA) DMZMTLB MT DTT DMZMTLB MA Inhibitor DMZMTLB RN Ohioensins F and G: protein tyrosine phosphatase 1B inhibitory benzonaphthoxanthenones from the Antarctic moss Polytrichastrum alpinum. Bioorg Med Chem Lett. 2008 Jan 15;18(2):772-5. DMZMTLB RU https://pubmed.ncbi.nlm.nih.gov/18053716 DMNUGTL DI DMNUGTL DMNUGTL DN Ohioensin C DMNUGTL MI TTELIN2 DMNUGTL MN PTPN1 messenger RNA (PTPN1 mRNA) DMNUGTL MT DTT DMNUGTL MA Inhibitor DMNUGTL RN Ohioensins F and G: protein tyrosine phosphatase 1B inhibitory benzonaphthoxanthenones from the Antarctic moss Polytrichastrum alpinum. Bioorg Med Chem Lett. 2008 Jan 15;18(2):772-5. DMNUGTL RU https://pubmed.ncbi.nlm.nih.gov/18053716 DMCT348 DI DMCT348 DMCT348 DN Ohioensin F DMCT348 MI TTELIN2 DMCT348 MN PTPN1 messenger RNA (PTPN1 mRNA) DMCT348 MT DTT DMCT348 MA Inhibitor DMCT348 RN Ohioensins F and G: protein tyrosine phosphatase 1B inhibitory benzonaphthoxanthenones from the Antarctic moss Polytrichastrum alpinum. Bioorg Med Chem Lett. 2008 Jan 15;18(2):772-5. DMCT348 RU https://pubmed.ncbi.nlm.nih.gov/18053716 DMLJBVP DI DMLJBVP DMLJBVP DN Ohioensin G DMLJBVP MI TTELIN2 DMLJBVP MN PTPN1 messenger RNA (PTPN1 mRNA) DMLJBVP MT DTT DMLJBVP MA Inhibitor DMLJBVP RN Ohioensins F and G: protein tyrosine phosphatase 1B inhibitory benzonaphthoxanthenones from the Antarctic moss Polytrichastrum alpinum. Bioorg Med Chem Lett. 2008 Jan 15;18(2):772-5. DMLJBVP RU https://pubmed.ncbi.nlm.nih.gov/18053716 DMN37KO DI DMN37KO DMN37KO DN o-hydroxyatorvastatin DMN37KO MI TTPADOQ DMN37KO MN HMG-CoA reductase (HMGCR) DMN37KO MT DTT DMN37KO MA Inhibitor DMN37KO RN Thermodynamic and structure guided design of statin based inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A reductase. J Med Chem. 2008 Jul 10;51(13):3804-13. DMN37KO RU https://pubmed.ncbi.nlm.nih.gov/18540668 DMN7KPQ DI DMN7KPQ DMN7KPQ DN OICR-9429 DMN7KPQ MI TT7OFWB DMN7KPQ MN WD repeat-containing protein 5 (WDR5) DMN7KPQ MT DTT DMN7KPQ MA Antagonist DMN7KPQ RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2831). DMN7KPQ RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2831 DM47CO1 DI DM47CO1 DM47CO1 DN Okadaic acid DM47CO1 MI TTG8HIM DM47CO1 MN Dual specificity protein phosphatase 1 (DUSP1) DM47CO1 MT DTT DM47CO1 MA Inhibitor DM47CO1 RN Inhibition of protein phosphatase 1 stimulates secretion of Alzheimer amyloid precursor protein. Mol Med. 1995 Jul;1(5):535-41. DM47CO1 RU https://pubmed.ncbi.nlm.nih.gov/8529119 DM47CO1 DI DM47CO1 DM47CO1 DN Okadaic acid DM47CO1 MI DTUGYRD DM47CO1 MN P-glycoprotein 1 (ABCB1) DM47CO1 MT DTP DM47CO1 MA Substrate DM47CO1 RN Fingerprint-based in silico models for the prediction of P-glycoprotein substrates and inhibitors. Bioorg Med Chem. 2012 Sep 15;20(18):5388-95. DM47CO1 RU https://doi.org/10.1016/j.bmc.2012.03.045 DMT1CZ0 DI DMT1CZ0 DMT1CZ0 DN OL-135 DMT1CZ0 MI TTDP1UC DMT1CZ0 MN Fatty acid amide hydrolase (FAAH) DMT1CZ0 MT DTT DMT1CZ0 MA Inhibitor DMT1CZ0 RN X-ray crystallographic analysis of alpha-ketoheterocycle inhibitors bound to a humanized variant of fatty acid amide hydrolase. J Med Chem. 2010 Jan 14;53(1):230-40. DMT1CZ0 RU https://pubmed.ncbi.nlm.nih.gov/19924997 DM5ZJ3G DI DM5ZJ3G DM5ZJ3G DN OL-92 DM5ZJ3G MI TTDP1UC DM5ZJ3G MN Fatty acid amide hydrolase (FAAH) DM5ZJ3G MT DTT DM5ZJ3G MA Inhibitor DM5ZJ3G RN Synthesis and evaluation of benzothiazole-based analogues as novel, potent, and selective fatty acid amide hydrolase inhibitors. J Med Chem. 2009 Jan 8;52(1):170-80. DM5ZJ3G RU https://pubmed.ncbi.nlm.nih.gov/19072118 DMVM78Q DI DMVM78Q DMVM78Q DN Olean-12-en-3beta,15alpha-diol DMVM78Q MI TT0IHXV DMVM78Q MN DNA topoisomerase II (TOP2) DMVM78Q MT DTT DMVM78Q MA Inhibitor DMVM78Q RN Screening of triterpenoids isolated from Phyllanthus flexuosus for DNA topoisomerase inhibitory activity. J Nat Prod. 2001 Dec;64(12):1545-7. DMVM78Q RU https://pubmed.ncbi.nlm.nih.gov/11754608 DMWDMJ3 DI DMWDMJ3 DMWDMJ3 DN OLEANOLIC_ACID DMWDMJ3 MI TTZHY6R DMWDMJ3 MN Glycogen phosphorylase muscle form (GP) DMWDMJ3 MT DTT DMWDMJ3 MA Inhibitor DMWDMJ3 RN Naturally occurring pentacyclic triterpenes as inhibitors of glycogen phosphorylase: synthesis, structure-activity relationships, and X-ray crystal... J Med Chem. 2008 Jun 26;51(12):3540-54. DMWDMJ3 RU https://pubmed.ncbi.nlm.nih.gov/18517260 DMWDMJ3 DI DMWDMJ3 DMWDMJ3 DN OLEANOLIC_ACID DMWDMJ3 MI TTIU7X1 DMWDMJ3 MN Herpes simplex virus DNA polymerase UL30 (HSV UL30) DMWDMJ3 MT DTT DMWDMJ3 MA Inhibitor DMWDMJ3 RN DNA polymerase beta inhibitors from Baeckea gunniana. J Nat Prod. 1999 Dec;62(12):1624-6. DMWDMJ3 RU https://pubmed.ncbi.nlm.nih.gov/10654412 DMWDMJ3 DI DMWDMJ3 DMWDMJ3 DN OLEANOLIC_ACID DMWDMJ3 MI TTELIN2 DMWDMJ3 MN PTPN1 messenger RNA (PTPN1 mRNA) DMWDMJ3 MT DTT DMWDMJ3 MA Inhibitor DMWDMJ3 RN Chemical Constituents of the Roots of Euphorbia micractina. J Nat Prod. 2009 Sep;72(9):1620-6. DMWDMJ3 RU https://pubmed.ncbi.nlm.nih.gov/19702283 DMYPJC3 DI DMYPJC3 DMYPJC3 DN Oleanonic acid DMYPJC3 MI TTZHY6R DMYPJC3 MN Glycogen phosphorylase muscle form (GP) DMYPJC3 MT DTT DMYPJC3 MA Inhibitor DMYPJC3 RN Naturally occurring pentacyclic triterpenes as inhibitors of glycogen phosphorylase: synthesis, structure-activity relationships, and X-ray crystal... J Med Chem. 2008 Jun 26;51(12):3540-54. DMYPJC3 RU https://pubmed.ncbi.nlm.nih.gov/18517260 DMYPJC3 DI DMYPJC3 DMYPJC3 DN Oleanonic acid DMYPJC3 MI TTELIN2 DMYPJC3 MN PTPN1 messenger RNA (PTPN1 mRNA) DMYPJC3 MT DTT DMYPJC3 MA Inhibitor DMYPJC3 RN Triterpenoids from the leaves of Diospyros kaki (persimmon) and their inhibitory effects on protein tyrosine phosphatase 1B. J Nat Prod. 2008 Oct;71(10):1775-8. DMYPJC3 RU https://pubmed.ncbi.nlm.nih.gov/18798681 DM54O1Z DI DM54O1Z DM54O1Z DN Oleic acid DM54O1Z MI DTKDTML DM54O1Z MN Fatty acid transport protein 1 (SLC27A1) DM54O1Z MT DTP DM54O1Z MA Substrate DM54O1Z RN The blood-brain barrier fatty acid transport protein 1 (FATP1/SLC27A1) supplies docosahexaenoic acid to the brain, and insulin facilitates transport. J Neurochem. 2017 May;141(3):400-412. DM54O1Z RU http://www.ncbi.nlm.nih.gov/pubmed/28035674 DM54O1Z DI DM54O1Z DM54O1Z DN Oleic acid DM54O1Z MI TTIV96N DM54O1Z MN Fatty acid-binding protein 1 (FABP1) DM54O1Z MT DTT DM54O1Z MA Inhibitor DM54O1Z RN Characterization of the drug binding specificity of rat liver fatty acid binding protein. J Med Chem. 2008 Jul 10;51(13):3755-64. DM54O1Z RU https://pubmed.ncbi.nlm.nih.gov/18533710 DM54O1Z DI DM54O1Z DM54O1Z DN Oleic acid DM54O1Z MI TTHWMFZ DM54O1Z MN Fatty acid-binding protein 4 (FABP4) DM54O1Z MT DTT DM54O1Z MA Inhibitor DM54O1Z RN Discovery of highly selective inhibitors of human fatty acid binding protein 4 (FABP4) by virtual screening. Bioorg Med Chem Lett. 2010 Jun 15;20(12):3675-9. DM54O1Z RU https://pubmed.ncbi.nlm.nih.gov/20471252 DMXCSVH DI DMXCSVH DMXCSVH DN Oleic acid anilide DMXCSVH MI TTMF541 DMXCSVH MN Liver carboxylesterase (CES1) DMXCSVH MT DTT DMXCSVH MA Inhibitor DMXCSVH RN Phenolic compounds from the roots of Lindera fruticosa. J Nat Prod. 2006 May;69(5):853-5. DMXCSVH RU https://pubmed.ncbi.nlm.nih.gov/16724860 DMXCSVH DI DMXCSVH DMXCSVH DN Oleic acid anilide DMXCSVH MI TTAK0IN DMXCSVH MN SOAT2 messenger RNA (SOAT2 mRNA) DMXCSVH MT DTT DMXCSVH MA Inhibitor DMXCSVH RN Anti-atherosclerotic and anti-inflammatory activities of catecholic xanthones and flavonoids isolated from Cudrania tricuspidata. Bioorg Med Chem Lett. 2006 Nov 1;16(21):5580-3. DMXCSVH RU https://pubmed.ncbi.nlm.nih.gov/16919944 DMI1CAJ DI DMI1CAJ DMI1CAJ DN oleocanthal DMI1CAJ MI TTELV3W DMI1CAJ MN Transformation-sensitive protein p120 (TRPA1) DMI1CAJ MT DTT DMI1CAJ MA Activator DMI1CAJ RN Unusual pungency from extra-virgin olive oil is attributable to restricted spatial expression of the receptor of oleocanthal. J Neurosci. 2011 Jan 19;31(3):999-1009. DMI1CAJ RU https://pubmed.ncbi.nlm.nih.gov/21248124 DMJ1VRU DI DMJ1VRU DMJ1VRU DN oleoyl-CoA DMJ1VRU MI TTH7UO3 DMJ1VRU MN Inward rectifier potassium channel Kir2.1 (KCNJ2) DMJ1VRU MT DTT DMJ1VRU MA Inhibitor (gating inhibitor) DMJ1VRU RN Cytoplasmic accumulation of long-chain coenzyme A esters activates KATP and inhibits Kir2.1 channels. J Physiol. 2006 Sep 1;575(Pt 2):433-42. DMJ1VRU RU https://pubmed.ncbi.nlm.nih.gov/16777940 DMB5KQ4 DI DMB5KQ4 DMB5KQ4 DN oleoyl-lysophosphatidylcholine DMB5KQ4 MI TT7QNVC DMB5KQ4 MN Glucose-dependent insulinotropic receptor (GPR119) DMB5KQ4 MT DTT DMB5KQ4 MA Agonist DMB5KQ4 RN Lysophosphatidylcholine enhances glucose-dependent insulin secretion via an orphan G-protein-coupled receptor. Biochem Biophys Res Commun. 2005 Jan 28;326(4):744-51. DMB5KQ4 RU https://pubmed.ncbi.nlm.nih.gov/15607732 DM1TAM9 DI DM1TAM9 DM1TAM9 DN oleoyl-thiophosphate DM1TAM9 MI TTE2YJR DM1TAM9 MN Lysophosphatidate-3 receptor (LPAR3) DM1TAM9 MT DTT DM1TAM9 MA Agonist DM1TAM9 RN Synthesis, structure-activity relationships, and biological evaluation of fatty alcohol phosphates as lysophosphatidic acid receptor ligands, activ... J Med Chem. 2005 Jul 28;48(15):4919-30. DM1TAM9 RU https://pubmed.ncbi.nlm.nih.gov/16033271 DM1TAM9 DI DM1TAM9 DM1TAM9 DN oleoyl-thiophosphate DM1TAM9 MI TTQ6S1K DM1TAM9 MN Lysophosphatidic acid receptor 1 (LPAR1) DM1TAM9 MT DTT DM1TAM9 MA Agonist DM1TAM9 RN Pharmacological tools for lysophospholipid GPCRs: development of agonists and antagonists for LPA and S1P receptors. Acta Pharmacol Sin. 2010 Sep;31(9):1213-22. DM1TAM9 RU https://pubmed.ncbi.nlm.nih.gov/20729877 DM1TAM9 DI DM1TAM9 DM1TAM9 DN oleoyl-thiophosphate DM1TAM9 MI TTB7Y8I DM1TAM9 MN Lysophosphatidic acid receptor 2 (LPAR2) DM1TAM9 MT DTT DM1TAM9 MA Agonist DM1TAM9 RN Synthesis, structure-activity relationships, and biological evaluation of fatty alcohol phosphates as lysophosphatidic acid receptor ligands, activ... J Med Chem. 2005 Jul 28;48(15):4919-30. DM1TAM9 RU https://pubmed.ncbi.nlm.nih.gov/16033271 DM5X76V DI DM5X76V DM5X76V DN Oligomycin C DM5X76V MI DEV62G1 DM5X76V MN Cytochrome P450 107W1 (cyp107) DM5X76V MT DME DM5X76V MA Metabolism DM5X76V RN nan DM5X76V RU nan DM1XJBE DI DM1XJBE DM1XJBE DN OLPADRONIC ACID SODIUM SALT DM1XJBE MI TTIKWV4 DM1XJBE MN Geranyltranstransferase (FDPS) DM1XJBE MT DTT DM1XJBE MA Modulator DM1XJBE RN Nitrogen-containing bisphosphonates inhibit isopentenyl pyrophosphate isomerase/farnesyl pyrophosphate synthase activity with relative potencies corresponding to their antiresorptive potencies in vitro and in vivo. Biochem Biophys Res Commun. 1999 Feb 16;255(2):491-4. DM1XJBE RU https://pubmed.ncbi.nlm.nih.gov/10049736 DMTY63G DI DMTY63G DMTY63G DN Olterodine DMTY63G MI TTQ13Z5 DMTY63G MN Muscarinic acetylcholine receptor M3 (CHRM3) DMTY63G MT DTT DMTY63G MA Antagonist DMTY63G RN Which muscarinic receptor is important in the bladder World J Urol. 2001 Nov;19(5):299-306. DMTY63G RU https://pubmed.ncbi.nlm.nih.gov/11760777 DMXJ2SM DI DMXJ2SM DMXJ2SM DN OM00-3 DMXJ2SM MI TT8JRS7 DMXJ2SM MN Beta-secretase (BACE) DMXJ2SM MT DTT DMXJ2SM MA Inhibitor DMXJ2SM RN Synthesis and biological evaluation of phosphino dipeptide isostere inhibitor of human beta-secretase (BACE1). Bioorg Med Chem. 2007 Jun 15;15(12):4136-43. DMXJ2SM RU https://pubmed.ncbi.nlm.nih.gov/17433698 DME8RNV DI DME8RNV DME8RNV DN OM-197-MP-AC DME8RNV MI TTISGCA DME8RNV MN Toll-like receptor 4 (TLR4) DME8RNV MT DTT DME8RNV MA Modulator DME8RNV RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1754). DME8RNV RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1754 DML5AWQ DI DML5AWQ DML5AWQ DN OM-294-DP DML5AWQ MI TTISGCA DML5AWQ MN Toll-like receptor 4 (TLR4) DML5AWQ MT DTT DML5AWQ MA Modulator DML5AWQ RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1754). DML5AWQ RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1754 DMGMIX3 DI DMGMIX3 DMGMIX3 DN omega-chloroacetophenone DMGMIX3 MI TTELV3W DMGMIX3 MN Transformation-sensitive protein p120 (TRPA1) DMGMIX3 MT DTT DMGMIX3 MA Activator DMGMIX3 RN Tear gasses CN, CR, and CS are potent activators of the human TRPA1 receptor. Toxicol Appl Pharmacol. 2008 Sep 1;231(2):150-6. DMGMIX3 RU https://pubmed.ncbi.nlm.nih.gov/18501939 DM4BQFW DI DM4BQFW DM4BQFW DN omega-conotoxin GVIA DM4BQFW MI TTX4QDJ DM4BQFW MN Voltage-gated calcium channel alpha Cav2.1 (CACNA1A) DM4BQFW MT DTT DM4BQFW MA Blocker (channel blocker) DM4BQFW RN Novel omega-conotoxins from Conus catus discriminate among neuronal calcium channel subtypes. J Biol Chem. 2000 Nov 10;275(45):35335-44. DM4BQFW RU https://pubmed.ncbi.nlm.nih.gov/10938268 DM4BQFW DI DM4BQFW DM4BQFW DN omega-conotoxin GVIA DM4BQFW MI TT4FDG6 DM4BQFW MN Voltage-gated calcium channel alpha Cav2.2 (CACNA1B) DM4BQFW MT DTT DM4BQFW MA Blocker (channel blocker) DM4BQFW RN Novel omega-conotoxins from Conus catus discriminate among neuronal calcium channel subtypes. J Biol Chem. 2000 Nov 10;275(45):35335-44. DM4BQFW RU https://pubmed.ncbi.nlm.nih.gov/10938268 DMKTA5R DI DMKTA5R DMKTA5R DN O-methyldauricine DMKTA5R MI TTVBI8W DMKTA5R MN Dopamine transporter (DAT) DMKTA5R MT DTT DMKTA5R MA Inhibitor DMKTA5R RN Effects of various isoquinoline alkaloids on in vitro 3H-dopamine uptake by rat striatal synaptosomes. J Nat Prod. 1995 Oct;58(10):1475-84. DMKTA5R RU https://pubmed.ncbi.nlm.nih.gov/8676127 DMGFRSY DI DMGFRSY DMGFRSY DN OMPT DMGFRSY MI TTE2YJR DMGFRSY MN Lysophosphatidate-3 receptor (LPAR3) DMGFRSY MT DTT DMGFRSY MA Agonist DMGFRSY RN Identification of a phosphothionate analogue of lysophosphatidic acid (LPA) as a selective agonist of the LPA3 receptor. J Biol Chem. 2003 Apr 4;278(14):11962-9. DMGFRSY RU https://pubmed.ncbi.nlm.nih.gov/12554733 DMWOHDV DI DMWOHDV DMWOHDV DN ON-044580 DMWOHDV MI TTIV39N DMWOHDV MN Fusion protein Bcr-Abl T315I mutant (Bcr-Abl T315I) DMWOHDV MT DTT DMWOHDV MA Inhibitor DMWOHDV RN A Non-ATP-Competitive Dual Inhibitor of JAK2 and BCR-ABL Kinases: Elucidation of a Novel Therapeutic Spectrum Based on Substrate Competitive Inhibition. Genes Cancer. 2010 Apr;1(4):331-45. DMWOHDV RU https://pubmed.ncbi.nlm.nih.gov/20717479 DMWOHDV DI DMWOHDV DMWOHDV DN ON-044580 DMWOHDV MI TTRMX3V DMWOHDV MN Janus kinase 2 (JAK-2) DMWOHDV MT DTT DMWOHDV MA Inhibitor DMWOHDV RN A Non-ATP-Competitive Dual Inhibitor of JAK2 and BCR-ABL Kinases: Elucidation of a Novel Therapeutic Spectrum Based on Substrate Competitive Inhibition. Genes Cancer. 2010 Apr;1(4):331-45. DMWOHDV RU https://pubmed.ncbi.nlm.nih.gov/20717479 DMHLEGT DI DMHLEGT DMHLEGT DN ON-123 DMHLEGT MI TT976FS DMHLEGT MN Polo-like kinase 2 (PLK2) DMHLEGT MT DTT DMHLEGT MA Inhibitor DMHLEGT RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2169). DMHLEGT RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2169 DMTNKBW DI DMTNKBW DMTNKBW DN ON-128 DMTNKBW MI TTGKNB4 DMTNKBW MN Epidermal growth factor receptor (EGFR) DMTNKBW MT DTT DMTNKBW MA Inhibitor DMTNKBW RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1797). DMTNKBW RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1797 DMSFQHO DI DMSFQHO DMSFQHO DN ON-24160 DMSFQHO MI TTYFKSZ DMSFQHO MN Tubulin beta (TUBB) DMSFQHO MT DTT DMSFQHO MA Inhibitor DMSFQHO RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2640). DMSFQHO RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2640 DMSWI4D DI DMSWI4D DMSWI4D DN Ono 1 DMSWI4D MI TTXHYV6 DMSWI4D MN Voltage-gated L-type calcium channel (L-CaC) DMSWI4D MT DTT DMSWI4D MA Blocker DMSWI4D RN Recent updates of N-type calcium channel blockers with therapeutic potential for neuropathic pain and stroke. Curr Top Med Chem. 2009;9(4):377-95. DMSWI4D RU https://pubmed.ncbi.nlm.nih.gov/19442208 DMCG6H8 DI DMCG6H8 DMCG6H8 DN Ono 3 DMCG6H8 MI TTXHYV6 DMCG6H8 MN Voltage-gated L-type calcium channel (L-CaC) DMCG6H8 MT DTT DMCG6H8 MA Blocker DMCG6H8 RN Recent updates of N-type calcium channel blockers with therapeutic potential for neuropathic pain and stroke. Curr Top Med Chem. 2009;9(4):377-95. DMCG6H8 RU https://pubmed.ncbi.nlm.nih.gov/19442208 DMSXT0H DI DMSXT0H DMSXT0H DN ONO-1581 DMSXT0H MI TTKNWZ4 DMSXT0H MN Thromboxane-A synthase (TBXAS1) DMSXT0H MT DTT DMSXT0H MA Inhibitor DMSXT0H RN Pharmacological evaluation of combined PGI2 agonists/thromboxane synthase inhibitors, Bioorg. Med. Chem. Lett. 5(10):1087-1090 (1995). DMSXT0H RU http://www.sciencedirect.com/science/article/pii/0960894X9500171O DM8LKED DI DM8LKED DM8LKED DN ONO-3080573 DM8LKED MI TTQ6S1K DM8LKED MN Lysophosphatidic acid receptor 1 (LPAR1) DM8LKED MT DTT DM8LKED MA Antagonist DM8LKED RN Crystal Structure of Antagonist Bound Human Lysophosphatidic Acid Receptor 1. Cell. 2015 Jun 18;161(7):1633-43. DM8LKED RU https://pubmed.ncbi.nlm.nih.gov/26091040 DM84IW9 DI DM84IW9 DM84IW9 DN ONO-3708 DM84IW9 MI TT2O84V DM84IW9 MN Thromboxane A2 receptor (TBXA2R) DM84IW9 MT DTT DM84IW9 MA Antagonist DM84IW9 RN Characterization of U46619 binding in unactivated, intact human platelets and determination of binding site affinities of four TXA2/PGH2 receptor antagonists (13-APA, BM 13.177, ONO 3708 and SQ 29,548). Thromb Res. 1986 Feb 15;41(4):471-81. DM84IW9 RU https://pubmed.ncbi.nlm.nih.gov/3008368 DMD2G65 DI DMD2G65 DMD2G65 DN ONO-8713 DMD2G65 MI TTG1QMU DMD2G65 MN Prostaglandin E2 receptor EP1 (PTGER1) DMD2G65 MT DTT DMD2G65 MA Antagonist DMD2G65 RN New class of biphenylene dibenzazocinones as potent ligands for the human EP1 prostanoid receptor. Bioorg Med Chem Lett. 1999 Sep 20;9(18):2699-704. DMD2G65 RU https://pubmed.ncbi.nlm.nih.gov/10509919 DMD2G65 DI DMD2G65 DMD2G65 DN ONO-8713 DMD2G65 MI TTPNGDE DMD2G65 MN Prostaglandin E2 receptor EP3 (PTGER3) DMD2G65 MT DTT DMD2G65 MA Agonist DMD2G65 RN Molecular cloning and characterization of the four rat prostaglandin E2 prostanoid receptor subtypes. Eur J Pharmacol. 1997 Dec 11;340(2-3):227-41. DMD2G65 RU https://pubmed.ncbi.nlm.nih.gov/9537820 DM5BMA9 DI DM5BMA9 DM5BMA9 DN ONO-8809 DM5BMA9 MI TT2O84V DM5BMA9 MN Thromboxane A2 receptor (TBXA2R) DM5BMA9 MT DTT DM5BMA9 MA Antagonist DM5BMA9 RN Anti-thrombotic effect of ONO-8809, a novel TXA2/PG endoperoxide receptor antagonist. Adv Prostaglandin Thromboxane Leukot Res. 1991;21B:599-602. DM5BMA9 RU https://pubmed.ncbi.nlm.nih.gov/1825384 DMATXHR DI DMATXHR DMATXHR DN ONO-9780307 DMATXHR MI TTQ6S1K DMATXHR MN Lysophosphatidic acid receptor 1 (LPAR1) DMATXHR MT DTT DMATXHR MA Antagonist DMATXHR RN Crystal Structure of Antagonist Bound Human Lysophosphatidic Acid Receptor 1. Cell. 2015 Jun 18;161(7):1633-43. DMATXHR RU https://pubmed.ncbi.nlm.nih.gov/26091040 DML4DPV DI DML4DPV DML4DPV DN ONO-9910539 DML4DPV MI TTQ6S1K DML4DPV MN Lysophosphatidic acid receptor 1 (LPAR1) DML4DPV MT DTT DML4DPV MA Antagonist DML4DPV RN Crystal Structure of Antagonist Bound Human Lysophosphatidic Acid Receptor 1. Cell. 2015 Jun 18;161(7):1633-43. DML4DPV RU https://pubmed.ncbi.nlm.nih.gov/26091040 DMS3MZG DI DMS3MZG DMS3MZG DN ONO-AE1-329 DMS3MZG MI TT1ZAVI DMS3MZG MN Prostaglandin E2 receptor EP2 (PTGER2) DMS3MZG MT DTT DMS3MZG MA Agonist DMS3MZG RN The role of prostaglandin E receptor subtypes (EP1, EP2, EP3, and EP4) in bone resorption: an analysis using specific agonists for the respective EPs. Endocrinology. 2000 Apr;141(4):1554-9. DMS3MZG RU https://pubmed.ncbi.nlm.nih.gov/10746663 DMS3MZG DI DMS3MZG DMS3MZG DN ONO-AE1-329 DMS3MZG MI TTPNGDE DMS3MZG MN Prostaglandin E2 receptor EP3 (PTGER3) DMS3MZG MT DTT DMS3MZG MA Agonist DMS3MZG RN The role of prostaglandin E receptor subtypes (EP1, EP2, EP3, and EP4) in bone resorption: an analysis using specific agonists for the respective EPs. Endocrinology. 2000 Apr;141(4):1554-9. DMS3MZG RU https://pubmed.ncbi.nlm.nih.gov/10746663 DMS3MZG DI DMS3MZG DMS3MZG DN ONO-AE1-329 DMS3MZG MI TT79WV3 DMS3MZG MN Prostaglandin E2 receptor EP4 (PTGER4) DMS3MZG MT DTT DMS3MZG MA Agonist DMS3MZG RN The role of prostaglandin E receptor subtypes (EP1, EP2, EP3, and EP4) in bone resorption: an analysis using specific agonists for the respective EPs. Endocrinology. 2000 Apr;141(4):1554-9. DMS3MZG RU https://pubmed.ncbi.nlm.nih.gov/10746663 DM78DO6 DI DM78DO6 DM78DO6 DN ONO-AE2-227 DM78DO6 MI TTPNGDE DM78DO6 MN Prostaglandin E2 receptor EP3 (PTGER3) DM78DO6 MT DTT DM78DO6 MA Antagonist DM78DO6 RN Involvement of prostaglandin E receptor subtype EP(4) in colon carcinogenesis. Cancer Res. 2002 Jan 1;62(1):28-32. DM78DO6 RU https://pubmed.ncbi.nlm.nih.gov/11782353 DM78DO6 DI DM78DO6 DM78DO6 DN ONO-AE2-227 DM78DO6 MI TT79WV3 DM78DO6 MN Prostaglandin E2 receptor EP4 (PTGER4) DM78DO6 MT DTT DM78DO6 MA Antagonist DM78DO6 RN Involvement of prostaglandin E receptor subtype EP(4) in colon carcinogenesis. Cancer Res. 2002 Jan 1;62(1):28-32. DM78DO6 RU https://pubmed.ncbi.nlm.nih.gov/11782353 DMA7VP5 DI DMA7VP5 DMA7VP5 DN ONO-AE-248 DMA7VP5 MI TT1ZAVI DMA7VP5 MN Prostaglandin E2 receptor EP2 (PTGER2) DMA7VP5 MT DTT DMA7VP5 MA Agonist DMA7VP5 RN The role of prostaglandin E receptor subtypes (EP1, EP2, EP3, and EP4) in bone resorption: an analysis using specific agonists for the respective EPs. Endocrinology. 2000 Apr;141(4):1554-9. DMA7VP5 RU https://pubmed.ncbi.nlm.nih.gov/10746663 DMA7VP5 DI DMA7VP5 DMA7VP5 DN ONO-AE-248 DMA7VP5 MI TTPNGDE DMA7VP5 MN Prostaglandin E2 receptor EP3 (PTGER3) DMA7VP5 MT DTT DMA7VP5 MA Agonist DMA7VP5 RN Selective activation of the prostanoid EP(3) receptor reduces myocardial infarct size in rodents. Arterioscler Thromb Vasc Biol. 1999 Sep;19(9):2141-7. DMA7VP5 RU https://pubmed.ncbi.nlm.nih.gov/10479656 DMEY7T4 DI DMEY7T4 DMEY7T4 DN ONO-AE3-208 DMEY7T4 MI TTPNGDE DMEY7T4 MN Prostaglandin E2 receptor EP3 (PTGER3) DMEY7T4 MT DTT DMEY7T4 MA Antagonist DMEY7T4 RN The prostaglandin receptor EP4 suppresses colitis, mucosal damage and CD4 cell activation in the gut. J Clin Invest. 2002 Apr;109(7):883-93. DMEY7T4 RU https://pubmed.ncbi.nlm.nih.gov/11927615 DMEY7T4 DI DMEY7T4 DMEY7T4 DN ONO-AE3-208 DMEY7T4 MI TT79WV3 DMEY7T4 MN Prostaglandin E2 receptor EP4 (PTGER4) DMEY7T4 MT DTT DMEY7T4 MA Antagonist DMEY7T4 RN The prostaglandin receptor EP4 suppresses colitis, mucosal damage and CD4 cell activation in the gut. J Clin Invest. 2002 Apr;109(7):883-93. DMEY7T4 RU https://pubmed.ncbi.nlm.nih.gov/11927615 DMGA4W5 DI DMGA4W5 DMGA4W5 DN ONO-AE3-237 DMGA4W5 MI TTNVEIR DMGA4W5 MN Prostaglandin D2 receptor (PTGDR) DMGA4W5 MT DTT DMGA4W5 MA Antagonist DMGA4W5 RN Prostaglandin D2 inhibits the production of IFN-gamma by invariant NK T cells: consequences in the control of B16 melanoma. J Immunol. 2008 Jan 15;180(2):783-92. DMGA4W5 RU https://pubmed.ncbi.nlm.nih.gov/18178816 DMN3OWP DI DMN3OWP DMN3OWP DN ONO-AE3-240 DMN3OWP MI TTPNGDE DMN3OWP MN Prostaglandin E2 receptor EP3 (PTGER3) DMN3OWP MT DTT DMN3OWP MA Antagonist DMN3OWP RN Host prostaglandin E(2)-EP3 signaling regulates tumor-associated angiogenesis and tumor growth. J Exp Med. 2003 Jan 20;197(2):221-32. DMN3OWP RU https://pubmed.ncbi.nlm.nih.gov/12538661 DMN3OWP DI DMN3OWP DMN3OWP DN ONO-AE3-240 DMN3OWP MI TT79WV3 DMN3OWP MN Prostaglandin E2 receptor EP4 (PTGER4) DMN3OWP MT DTT DMN3OWP MA Antagonist DMN3OWP RN Host prostaglandin E(2)-EP3 signaling regulates tumor-associated angiogenesis and tumor growth. J Exp Med. 2003 Jan 20;197(2):221-32. DMN3OWP RU https://pubmed.ncbi.nlm.nih.gov/12538661 DMDA7M9 DI DMDA7M9 DMDA7M9 DN ONO-AE5-599 DMDA7M9 MI TTPNGDE DMDA7M9 MN Prostaglandin E2 receptor EP3 (PTGER3) DMDA7M9 MT DTT DMDA7M9 MA Antagonist DMDA7M9 RN Involvement of prostaglandin E receptor EP3 subtype in duodenal bicarbonate secretion in rats. Life Sci. 2007 Jun 6;80(26):2446-53. DMDA7M9 RU https://pubmed.ncbi.nlm.nih.gov/17512019 DMA1NL9 DI DMA1NL9 DMA1NL9 DN ONO-AP-324 DMA1NL9 MI TTPNGDE DMA1NL9 MN Prostaglandin E2 receptor EP3 (PTGER3) DMA1NL9 MT DTT DMA1NL9 MA Agonist DMA1NL9 RN Characterization of a prostanoid EP3-receptor in guinea-pig aorta: partial agonist action of the non-prostanoid ONO-AP-324. Br J Pharmacol. 1998 Nov;125(6):1288-96. DMA1NL9 RU https://pubmed.ncbi.nlm.nih.gov/9863659 DM81RKT DI DM81RKT DM81RKT DN ONO-DI-004 DM81RKT MI TTG1QMU DM81RKT MN Prostaglandin E2 receptor EP1 (PTGER1) DM81RKT MT DTT DM81RKT MA Agonist DM81RKT RN The role of prostaglandin E receptor subtypes (EP1, EP2, EP3, and EP4) in bone resorption: an analysis using specific agonists for the respective EPs. Endocrinology. 2000 Apr;141(4):1554-9. DM81RKT RU https://pubmed.ncbi.nlm.nih.gov/10746663 DMDR95N DI DMDR95N DMDR95N DN O-oleoyl-N-(2-hydroxyethyl)hydroxylamine DMDR95N MI TTMSFAW DMDR95N MN Cannabinoid receptor 2 (CB2) DMDR95N MT DTT DMDR95N MA Inhibitor DMDR95N RN Oxyhomologues of anandamide and related endolipids: chemoselective synthesis and biological activity. J Med Chem. 2006 Apr 6;49(7):2333-8. DMDR95N RU https://pubmed.ncbi.nlm.nih.gov/16570929 DMQOJY2 DI DMQOJY2 DMQOJY2 DN OPC 4392 DMQOJY2 MI TTJS8PY DMQOJY2 MN 5-HT 6 receptor (HTR6) DMQOJY2 MT DTT DMQOJY2 MA Agonist DMQOJY2 RN Interactions of the novel antipsychotic aripiprazole (OPC-14597) with dopamine and serotonin receptor subtypes. Neuropsychopharmacology. 1999 Jun;20(6):612-27. DMQOJY2 RU https://pubmed.ncbi.nlm.nih.gov/10327430 DMQOJY2 DI DMQOJY2 DMQOJY2 DN OPC 4392 DMQOJY2 MI TTO9X1H DMQOJY2 MN 5-HT 7 receptor (HTR7) DMQOJY2 MT DTT DMQOJY2 MA Agonist DMQOJY2 RN Interactions of the novel antipsychotic aripiprazole (OPC-14597) with dopamine and serotonin receptor subtypes. Neuropsychopharmacology. 1999 Jun;20(6):612-27. DMQOJY2 RU https://pubmed.ncbi.nlm.nih.gov/10327430 DMO4WH9 DI DMO4WH9 DMO4WH9 DN OPC-22575 DMO4WH9 MI TTF1QVM DMO4WH9 MN Gastric H(+)/K(+) ATPase alpha (ATP4A) DMO4WH9 MT DTT DMO4WH9 MA Modulator DMO4WH9 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 849). DMO4WH9 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=849 DM3O9YW DI DM3O9YW DM3O9YW DN O-Phosphoethanolamine DM3O9YW MI TTYPXQF DM3O9YW MN Protein kinase C beta (PRKCB) DM3O9YW MT DTT DM3O9YW MA Inhibitor DM3O9YW RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DM3O9YW RU https://pubmed.ncbi.nlm.nih.gov/17139284 DM0XT69 DI DM0XT69 DM0XT69 DN orexin-B DM0XT69 MI TT60Q8D DM0XT69 MN Orexin receptor type 1 (HCRTR1) DM0XT69 MT DTT DM0XT69 MA Agonist DM0XT69 RN Agonist ligand discrimination by the two orexin receptors depends on the expression system. Neurosci Lett. 2011 Apr 20;494(1):57-60. DM0XT69 RU https://pubmed.ncbi.nlm.nih.gov/21362456 DM0XT69 DI DM0XT69 DM0XT69 DN orexin-B DM0XT69 MI TT9N02I DM0XT69 MN Orexin receptor type 2 (HCRTR2) DM0XT69 MT DTT DM0XT69 MA Agonist DM0XT69 RN The signalling profile of recombinant human orexin-2 receptor. Cell Signal. 2008 Sep;20(9):1651-61. DM0XT69 RU https://pubmed.ncbi.nlm.nih.gov/18599270 DM8JUBG DI DM8JUBG DM8JUBG DN Org 12962 DM8JUBG MI TTJQOD7 DM8JUBG MN 5-HT 2A receptor (HTR2A) DM8JUBG MT DTT DM8JUBG MA Agonist DM8JUBG RN Pharmacological characterisation of the agonist radioligand binding site of 5-HT(2A), 5-HT(2B) and 5-HT(2C) receptors. Naunyn Schmiedebergs Arch Pharmacol. 2004 Aug;370(2):114-23. DM8JUBG RU https://pubmed.ncbi.nlm.nih.gov/15322733 DM8JUBG DI DM8JUBG DM8JUBG DN Org 12962 DM8JUBG MI TT0K1SC DM8JUBG MN 5-HT 2B receptor (HTR2B) DM8JUBG MT DTT DM8JUBG MA Agonist DM8JUBG RN Pharmacological characterisation of the agonist radioligand binding site of 5-HT(2A), 5-HT(2B) and 5-HT(2C) receptors. Naunyn Schmiedebergs Arch Pharmacol. 2004 Aug;370(2):114-23. DM8JUBG RU https://pubmed.ncbi.nlm.nih.gov/15322733 DM8JUBG DI DM8JUBG DM8JUBG DN Org 12962 DM8JUBG MI TTWJBZ5 DM8JUBG MN 5-HT 2C receptor (HTR2C) DM8JUBG MT DTT DM8JUBG MA Agonist DM8JUBG RN Pharmacological characterisation of the agonist radioligand binding site of 5-HT(2A), 5-HT(2B) and 5-HT(2C) receptors. Naunyn Schmiedebergs Arch Pharmacol. 2004 Aug;370(2):114-23. DM8JUBG RU https://pubmed.ncbi.nlm.nih.gov/15322733 DMH1M6N DI DMH1M6N DMH1M6N DN ORG2058 DMH1M6N MI TTUV8G9 DMH1M6N MN Progesterone receptor (PGR) DMH1M6N MT DTT DMH1M6N MA Agonist DMH1M6N RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 627). DMH1M6N RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=627 DMTFGYH DI DMTFGYH DMTFGYH DN Org-231295 DMTFGYH MI TTDP1UC DMTFGYH MN Fatty acid amide hydrolase (FAAH) DMTFGYH MT DTT DMTFGYH MA Inhibitor DMTFGYH RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1400). DMTFGYH RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1400 DMRU3H0 DI DMRU3H0 DMRU3H0 DN Org27569 DMRU3H0 MI TT6OEDT DMRU3H0 MN Cannabinoid receptor 1 (CB1) DMRU3H0 MT DTT DMRU3H0 MA Modulator (allosteric modulator) DMRU3H0 RN Indole-2-carboxamides as allosteric modulators of the cannabinoid CB receptor. J Med Chem. 2012 Jun 14;55(11):5627-31. DMRU3H0 RU https://pubmed.ncbi.nlm.nih.gov/22571451 DMXGA56 DI DMXGA56 DMXGA56 DN Org-30850 DMXGA56 MI TT8R70G DMXGA56 MN Gonadotropin-releasing hormone receptor (GNRHR) DMXGA56 MT DTT DMXGA56 MA Modulator DMXGA56 RN In vivo effects of a potent GnRH antagonist ORG 30850: physiologic evidence that down-regulation of GnRH receptors does not occur. J Soc Gynecol Investig. 1994 Oct-Dec;1(4):290-6. DMXGA56 RU https://www.ncbi.nlm.nih.gov/pubmed/9419786 DMDY38R DI DMDY38R DMDY38R DN Org-33201 DMDY38R MI TTSZLWK DMDY38R MN Aromatase (CYP19A1) DMDY38R MT DTT DMDY38R MA Modulator DMDY38R RN Org 33201: a new highly selective orally active aromatase inhibitor. J Steroid Biochem Mol Biol. 1993 Mar;44(4-6):681-2. DMDY38R RU https://www.ncbi.nlm.nih.gov/pubmed/8476784 DM4SFKW DI DM4SFKW DM4SFKW DN Org-36764 DM4SFKW MI TT4QPUL DM4SFKW MN Antithrombin-III (ATIII) DM4SFKW MT DTT DM4SFKW MA Modulator DM4SFKW RN Pre-clinical pharmacological profile of the novel glycoconjugate Org 36764 with both factor Xa and thrombin (IIa) inhibitory activities. Thromb Haemost. 2000 Oct;84(4):611-20. DM4SFKW RU https://www.ncbi.nlm.nih.gov/pubmed/11057859 DM3EZDG DI DM3EZDG DM3EZDG DN Org-37663 DM3EZDG MI TTZAYWL DM3EZDG MN Estrogen receptor (ESR) DM3EZDG MT DTT DM3EZDG MA Modulator DM3EZDG RN The selective estrogen receptor alpha agonist Org 37663 induces estrogenic effects but lacks antirheumatic activity: a phase IIa trial investigating efficacy and safety of Org 37663 in postmenopausal female rheumatoid arthritis patients receiving stable background methotrexate or sulfasalazine.Arthritis Rheum.2010 Feb;62(2):351-8. DM3EZDG RU https://www.ncbi.nlm.nih.gov/pubmed/20112368 DMPQGUL DI DMPQGUL DMPQGUL DN ORIPAVINE DMPQGUL MI TTKWM86 DMPQGUL MN Opioid receptor mu (MOP) DMPQGUL MT DTT DMPQGUL MA Inhibitor DMPQGUL RN Live cell monitoring of mu-opioid receptor-mediated G-protein activation reveals strong biological activity of close morphine biosynthetic precursors. J Biol Chem. 2007 Sep 14;282(37):27126-32. DMPQGUL RU https://pubmed.ncbi.nlm.nih.gov/17616524 DMA2DQT DI DMA2DQT DMA2DQT DN OROIDIN DMA2DQT MI TTIDAPM DMA2DQT MN ERK activator kinase 1 (MEK1) DMA2DQT MT DTT DMA2DQT MA Inhibitor DMA2DQT RN Aldisine alkaloids from the Philippine sponge Stylissa massa are potent inhibitors of mitogen-activated protein kinase kinase-1 (MEK-1). J Med Chem. 2002 Jan 17;45(2):529-32. DMA2DQT RU https://pubmed.ncbi.nlm.nih.gov/11784156 DMA2DQT DI DMA2DQT DMA2DQT DN OROIDIN DMA2DQT MI TTNX2CS DMA2DQT MN Plasmodium Enoyl-ACP reductase (Malaria fabI) DMA2DQT MT DTT DMA2DQT MA Inhibitor DMA2DQT RN Marine natural products from the Turkish sponge Agelas oroides that inhibit the enoyl reductases from Plasmodium falciparum, Mycobacterium tubercul... Bioorg Med Chem. 2007 Nov 1;15(21):6834-45. DMA2DQT RU https://pubmed.ncbi.nlm.nih.gov/17765547 DMMB29S DI DMMB29S DMMB29S DN Orotate DMMB29S MI TT09NOX DMMB29S MN Plasmodium Dihydroorotase (Malaria dho) DMMB29S MT DTT DMMB29S MA Inhibitor DMMB29S RN Antimalarial activity of orotate analogs that inhibit dihydroorotase and dihydroorotate dehydrogenase. Biochem Pharmacol. 1992 Mar 17;43(6):1295-301. DMMB29S RU https://pubmed.ncbi.nlm.nih.gov/1348618 DMMB29S DI DMMB29S DMMB29S DN Orotate DMMB29S MI TT3PQ2Y DMMB29S MN Plasmodium Dihydroorotate dehydrogenase (Malaria DHOdehase) DMMB29S MT DTT DMMB29S MA Inhibitor DMMB29S RN Antimalarial activity of orotate analogs that inhibit dihydroorotase and dihydroorotate dehydrogenase. Biochem Pharmacol. 1992 Mar 17;43(6):1295-301. DMMB29S RU https://pubmed.ncbi.nlm.nih.gov/1348618 DMMB29S DI DMMB29S DMMB29S DN Orotate DMMB29S MI DT2WLAD DMMB29S MN Urate anion exchanger 1 (SLC22A12) DMMB29S MT DTP DMMB29S MA Substrate DMMB29S RN Human urate transporter 1 (hURAT1) mediates the transport of orotate. J Physiol Sci. 2011 May;61(3):253-7. DMMB29S RU http://www.ncbi.nlm.nih.gov/pubmed/21350910 DMP6BSH DI DMP6BSH DMP6BSH DN Orotic acid DMP6BSH MI TT3PQ2Y DMP6BSH MN Plasmodium Dihydroorotate dehydrogenase (Malaria DHOdehase) DMP6BSH MT DTT DMP6BSH MA Inhibitor DMP6BSH RN Structure-activity relationships of pyrimidines as dihydroorotate dehydrogenase inhibitors. Biochem Pharmacol. 1988 Oct 15;37(20):3807-16. DMP6BSH RU https://pubmed.ncbi.nlm.nih.gov/2847745 DMGRXD4 DI DMGRXD4 DMGRXD4 DN Orthovanadate DMGRXD4 MI TTCWXFA DMGRXD4 MN Protein-tyrosine phosphatase sigma (R-PTP-sigma) DMGRXD4 MT DTT DMGRXD4 MA Inhibitor DMGRXD4 RN Human protein tyrosine phosphatase-sigma: alternative splicing and inhibition by bisphosphonates. J Bone Miner Res. 1996 Apr;11(4):535-43. DMGRXD4 RU https://pubmed.ncbi.nlm.nih.gov/8992885 DMK6X5P DI DMK6X5P DMK6X5P DN OSCILLARIN DMK6X5P MI TT6L509 DMK6X5P MN Coagulation factor IIa (F2) DMK6X5P MT DTT DMK6X5P MA Inhibitor DMK6X5P RN From natural products to achiral drug prototypes: potent thrombin inhibitors based on P2/P3 dihydropyrid-2-one core motifs. Bioorg Med Chem Lett. 2009 Sep 15;19(18):5429-32. DMK6X5P RU https://pubmed.ncbi.nlm.nih.gov/19674897 DM5IGN7 DI DM5IGN7 DM5IGN7 DN OSI-75 DM5IGN7 MI TTGKNB4 DM5IGN7 MN Epidermal growth factor receptor (EGFR) DM5IGN7 MT DTT DM5IGN7 MA Inhibitor DM5IGN7 RN Selected novel anticancer treatments targeting cell signaling proteins. Oncologist. 2001;6(6):517-37. DM5IGN7 RU https://pubmed.ncbi.nlm.nih.gov/11743214 DMCAR7B DI DMCAR7B DMCAR7B DN O-Sialic Acid DMCAR7B MI TTAU4D6 DMCAR7B MN E-selectin (SELE) DMCAR7B MT DTT DMCAR7B MA Inhibitor DMCAR7B RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DMCAR7B RU https://pubmed.ncbi.nlm.nih.gov/10592235 DMCAR7B DI DMCAR7B DMCAR7B DN O-Sialic Acid DMCAR7B MI TT50QJ3 DMCAR7B MN Influenza Neuraminidase (Influ NA) DMCAR7B MT DTT DMCAR7B MA Inhibitor DMCAR7B RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DMCAR7B RU https://pubmed.ncbi.nlm.nih.gov/10592235 DMCAR7B DI DMCAR7B DMCAR7B DN O-Sialic Acid DMCAR7B MI TTMF541 DMCAR7B MN Liver carboxylesterase (CES1) DMCAR7B MT DTT DMCAR7B MA Inhibitor DMCAR7B RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DMCAR7B RU https://pubmed.ncbi.nlm.nih.gov/10592235 DMCAR7B DI DMCAR7B DMCAR7B DN O-Sialic Acid DMCAR7B MI TTE5VG0 DMCAR7B MN P-selectin (SELP) DMCAR7B MT DTT DMCAR7B MA Inhibitor DMCAR7B RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DMCAR7B RU https://pubmed.ncbi.nlm.nih.gov/10592235 DM3FS62 DI DM3FS62 DM3FS62 DN O-spiroketal glucoside DM3FS62 MI TTF8JAT DM3FS62 MN SLC5A2 messenger RNA (SLC5A2 mRNA) DM3FS62 MT DTT DM3FS62 MA Inhibitor DM3FS62 RN ortho-Substituted C-aryl glucosides as highly potent and selective renal sodium-dependent glucose co-transporter 2 (SGLT2) inhibitors. Bioorg Med Chem. 2010 Jun 15;18(12):4422-32. DM3FS62 RU https://pubmed.ncbi.nlm.nih.gov/20576578 DM3FS62 DI DM3FS62 DM3FS62 DN O-spiroketal glucoside DM3FS62 MI TT2UE56 DM3FS62 MN Sodium/glucose cotransporter 1 (SGLT1) DM3FS62 MT DTT DM3FS62 MA Inhibitor DM3FS62 RN ortho-Substituted C-aryl glucosides as highly potent and selective renal sodium-dependent glucose co-transporter 2 (SGLT2) inhibitors. Bioorg Med Chem. 2010 Jun 15;18(12):4422-32. DM3FS62 RU https://pubmed.ncbi.nlm.nih.gov/20576578 DMQPJXT DI DMQPJXT DMQPJXT DN OSU-53 DMQPJXT MI TTLAFZV DMQPJXT MN AMP-activated protein kinase (AMPK) DMQPJXT MT DTT DMQPJXT MA Activator DMQPJXT RN A novel dual AMPK activator/mTOR inhibitor inhibits thyroid cancer cell growth. J Clin Endocrinol Metab. 2015 May;100(5):E748-56. DMQPJXT RU https://pubmed.ncbi.nlm.nih.gov/25710562 DM0R6MT DI DM0R6MT DM0R6MT DN O-tolyl 10H-phenothiazine-10-carboxylate DM0R6MT MI TTEB0GD DM0R6MT MN Cholinesterase (BCHE) DM0R6MT MT DTT DM0R6MT MA Inhibitor DM0R6MT RN Carbamates with differential mechanism of inhibition toward acetylcholinesterase and butyrylcholinesterase. J Med Chem. 2008 Jul 24;51(14):4200-12. DM0R6MT RU https://pubmed.ncbi.nlm.nih.gov/18570368 DMXP72F DI DMXP72F DMXP72F DN OTS964 DMXP72F MI TTMY6BZ DMXP72F MN PDZ binding kinase (PBK) DMXP72F MT DTT DMXP72F MA Inhibitor DMXP72F RN TOPK inhibitor induces complete tumor regression in xenograft models of human cancer through inhibition of cytokinesis. Sci Transl Med. 2014 Oct 22;6(259):259ra145. DMXP72F RU https://pubmed.ncbi.nlm.nih.gov/25338756 DMM4CE7 DI DMM4CE7 DMM4CE7 DN Ovalicin DMM4CE7 MI TTZL0OI DMM4CE7 MN Methionine aminopeptidase 2 (METAP2) DMM4CE7 MT DTT DMM4CE7 MA Inhibitor DMM4CE7 RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMM4CE7 RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMAV9PS DI DMAV9PS DMAV9PS DN OVI-117 DMAV9PS MI TTU6BFZ DMAV9PS MN Candida Thymidylate synthase (Candi TMP1) DMAV9PS MT DTT DMAV9PS MA Modulator DMAV9PS RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2642). DMAV9PS RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2642 DMCFM2E DI DMCFM2E DMCFM2E DN OXA-01 DMCFM2E MI TTCJG29 DMCFM2E MN Serine/threonine-protein kinase mTOR (mTOR) DMCFM2E MT DTT DMCFM2E MA Inhibitor DMCFM2E RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2109). DMCFM2E RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2109 DMPZSV1 DI DMPZSV1 DMPZSV1 DN Oxalacetic acid DMPZSV1 MI DENCJTA DMPZSV1 MN Oxaloacetate decarboxylase (FAHD1) DMPZSV1 MT DME DMPZSV1 MA Metabolism DMPZSV1 RN Identification of FAH domain-containing protein 1 (FAHD1) as oxaloacetate decarboxylase. J Biol Chem. 2015 Mar 13;290(11):6755-62. DMPZSV1 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=25575590 DMPZSV1 DI DMPZSV1 DMPZSV1 DN Oxalacetic acid DMPZSV1 MI DEPLH5Z DMPZSV1 MN Phosphoenolpyruvate carboxykinase (PCK1) DMPZSV1 MT DME DMPZSV1 MA Metabolism DMPZSV1 RN Tyr235 of human cytosolic phosphoenolpyruvate carboxykinase influences catalysis through an anion-quadrupole interaction with phosphoenolpyruvate carboxylate. FEBS J. 2008 Dec;275(23):5810-9. DMPZSV1 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=19021757 DM40SEU DI DM40SEU DM40SEU DN Oxalate DM40SEU MI DTVGOLN DM40SEU MN Anion exchange transporter (SLC26A6) DM40SEU MT DTP DM40SEU MA Substrate DM40SEU RN Oxalate (urine, plasma) DM40SEU RU http://www.acb.org.uk/Nat%20Lab%20Med%20Hbk/Oxalate.pdf DM40SEU DI DM40SEU DM40SEU DN Oxalate DM40SEU MI DTOTME4 DM40SEU MN Anion exchange transporter (SLC26A7) DM40SEU MT DTP DM40SEU MA Substrate DM40SEU RN The Transporter Classification Database (TCDB): recent advances. Nucleic Acids Res. 2016 Jan 4;44(D1):D372-9. (ID: 2.A.53.2.6) DM40SEU RU http://www.tcdb.org/search/result.php?tc=2.A.53.2.6 DM40SEU DI DM40SEU DM40SEU DN Oxalate DM40SEU MI DTJ785O DM40SEU MN Sulfate anion transporter 1 (SLC26A1) DM40SEU MT DTP DM40SEU MA Substrate DM40SEU RN Mutations in SLC26A1 Cause Nephrolithiasis. Am J Hum Genet. 2016 Jun 2;98(6):1228-1234. DM40SEU RU http://www.ncbi.nlm.nih.gov/pubmed/27210743 DMLN2GQ DI DMLN2GQ DMLN2GQ DN Oxalic Acid DMLN2GQ MI TT6PKBN DMLN2GQ MN Proto-oncogene c-Src (SRC) DMLN2GQ MT DTT DMLN2GQ MA Inhibitor DMLN2GQ RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMLN2GQ RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMT7XYE DI DMT7XYE DMT7XYE DN Oxalylaminobenzoic acid DMT7XYE MI TTELIN2 DMT7XYE MN PTPN1 messenger RNA (PTPN1 mRNA) DMT7XYE MT DTT DMT7XYE MA Inhibitor DMT7XYE RN Synthesis and evaluation of some novel dibenzo[b,d]furan carboxylic acids as potential anti-diabetic agents. Eur J Med Chem. 2010 Sep;45(9):3709-18. DMT7XYE RU https://pubmed.ncbi.nlm.nih.gov/20627471 DMTYBC9 DI DMTYBC9 DMTYBC9 DN OXAMATE DMTYBC9 MI TTT2LD9 DMTYBC9 MN GABA transaminase (ABAT) DMTYBC9 MT DTT DMTYBC9 MA Inhibitor DMTYBC9 RN Aminomethyl-1,2,4-benzothiadiazines as potential analogues of gamma-aminobutyric acid. Unexpected discovery of a taurine antagonist. J Med Chem. 1982 Feb;25(2):113-6. DMTYBC9 RU https://pubmed.ncbi.nlm.nih.gov/6276545 DMTYBC9 DI DMTYBC9 DMTYBC9 DN OXAMATE DMTYBC9 MI TTAZHU0 DMTYBC9 MN L-lactate dehydrogenase (LDH) DMTYBC9 MT DTT DMTYBC9 MA Inhibitor DMTYBC9 RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMTYBC9 RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMWVLG1 DI DMWVLG1 DMWVLG1 DN Oxametacin DMWVLG1 MI TT8NGED DMWVLG1 MN Prostaglandin G/H synthase 1 (COX-1) DMWVLG1 MT DTT DMWVLG1 MA Inhibitor DMWVLG1 RN Structure-based design, synthesis, and biological evaluation of indomethacin derivatives as cyclooxygenase-2 inhibiting nitric oxide donors. J Med Chem. 2007 Dec 13;50(25):6367-82. DMWVLG1 RU https://pubmed.ncbi.nlm.nih.gov/17994684 DMWVLG1 DI DMWVLG1 DMWVLG1 DN Oxametacin DMWVLG1 MI TTVKILB DMWVLG1 MN Prostaglandin G/H synthase 2 (COX-2) DMWVLG1 MT DTT DMWVLG1 MA Inhibitor DMWVLG1 RN Structure-based design, synthesis, and biological evaluation of indomethacin derivatives as cyclooxygenase-2 inhibiting nitric oxide donors. J Med Chem. 2007 Dec 13;50(25):6367-82. DMWVLG1 RU https://pubmed.ncbi.nlm.nih.gov/17994684 DM8109D DI DM8109D DM8109D DN Oxazolidin-(2Z)-ylideneamine DM8109D MI TTF10I9 DM8109D MN Nitric-oxide synthase inducible (NOS2) DM8109D MT DTT DM8109D MA Inhibitor DM8109D RN 4,5-Disubstituted-1,3-oxazolidin-2-imine derivatives: a new class of orally bioavailable nitric oxide synthase inhibitor. Bioorg Med Chem Lett. 2004 Jan 19;14(2):313-6. DM8109D RU https://pubmed.ncbi.nlm.nih.gov/14698148 DMMEDJT DI DMMEDJT DMMEDJT DN OXDEX DMMEDJT MI TTOZRK6 DMMEDJT MN Glucocorticoid receptor messenger RNA (GCR mRNA) DMMEDJT MT DTT DMMEDJT MA Inhibitor DMMEDJT RN Investigation of the relative cellular permeability of DNA-binding pyrrole-imidazole polyamides. J Med Chem. 2009 Aug 13;52(15):4604-12. DMMEDJT RU https://pubmed.ncbi.nlm.nih.gov/19610652 DM6RJOI DI DM6RJOI DM6RJOI DN OXENDLONE DM6RJOI MI TTS64P2 DM6RJOI MN Androgen receptor (AR) DM6RJOI MT DTT DM6RJOI MA Inhibitor DM6RJOI RN Antiandrogenic natural Diels--Alder-type adducts from Brosimum rubescens. J Nat Prod. 1997 Oct;60(10):997-1002. DM6RJOI RU https://pubmed.ncbi.nlm.nih.gov/9358642 DMG6O0L DI DMG6O0L DMG6O0L DN Oximidine I DMG6O0L MI TTTK3BH DMG6O0L MN Vacuolar-type proton ATPase (v-ATPase) DMG6O0L MT DTT DMG6O0L MA Inhibitor DMG6O0L RN Discovery of a novel antitumor benzolactone enamide class that selectively inhibits mammalian vacuolar-type (H+)-atpases. J Pharmacol Exp Ther. 2001 Apr;297(1):114-20. DMG6O0L RU https://pubmed.ncbi.nlm.nih.gov/11259534 DMW6K80 DI DMW6K80 DMW6K80 DN Oximidine II DMW6K80 MI TTTK3BH DMW6K80 MN Vacuolar-type proton ATPase (v-ATPase) DMW6K80 MT DTT DMW6K80 MA Inhibitor DMW6K80 RN Discovery of a novel antitumor benzolactone enamide class that selectively inhibits mammalian vacuolar-type (H+)-atpases. J Pharmacol Exp Ther. 2001 Apr;297(1):114-20. DMW6K80 RU https://pubmed.ncbi.nlm.nih.gov/11259534 DMM5208 DI DMM5208 DMM5208 DN Oxindole 16 (compound 3) DMM5208 MI TTL4Q97 DMM5208 MN Cyclin-dependent kinase 5 (CDK5) DMM5208 MT DTT DMM5208 MA Inhibitor DMM5208 RN Pharmacological inhibitors of cyclin-dependent kinases. Trends Pharmacol Sci. 2002 Sep;23(9):417-25. DMM5208 RU https://pubmed.ncbi.nlm.nih.gov/12237154 DMM5208 DI DMM5208 DMM5208 DN Oxindole 16 (compound 3) DMM5208 MI TTBJR4L DMM5208 MN Cyclin-dependent kinase 8 (CDK8) DMM5208 MT DTT DMM5208 MA Inhibitor DMM5208 RN Pharmacological inhibitors of cyclin-dependent kinases. Trends Pharmacol Sci. 2002 Sep;23(9):417-25. DMM5208 RU https://pubmed.ncbi.nlm.nih.gov/12237154 DMPFD6Y DI DMPFD6Y DMPFD6Y DN Oxindole 94 DMPFD6Y MI TTBJR4L DMPFD6Y MN Cyclin-dependent kinase 8 (CDK8) DMPFD6Y MT DTT DMPFD6Y MA Inhibitor DMPFD6Y RN Pharmacological inhibitors of cyclin-dependent kinases. Trends Pharmacol Sci. 2002 Sep;23(9):417-25. DMPFD6Y RU https://pubmed.ncbi.nlm.nih.gov/12237154 DMPFD6Y DI DMPFD6Y DMPFD6Y DN Oxindole 94 DMPFD6Y MI TTVKILB DMPFD6Y MN Prostaglandin G/H synthase 2 (COX-2) DMPFD6Y MT DTT DMPFD6Y MA Inhibitor DMPFD6Y RN A selective inhibitor of p38 MAP kinase, SB202190, induced apoptotic cell death of a lipopolysaccharide-treated macrophage-like cell line, J774.1. Biochim Biophys Acta. 2000 Oct 18;1502(2):207-23. DMPFD6Y RU https://pubmed.ncbi.nlm.nih.gov/11040446 DMPFD6Y DI DMPFD6Y DMPFD6Y DN Oxindole 94 DMPFD6Y MI TTQBR95 DMPFD6Y MN Stress-activated protein kinase 2a (p38 alpha) DMPFD6Y MT DTT DMPFD6Y MA Inhibitor DMPFD6Y RN Inhibition of p38 MAPK decreases myocardial TNF-alpha expression and improves myocardial function and survival in endotoxemia. Cardiovasc Res. 2003 Oct 1;59(4):893-900. DMPFD6Y RU https://pubmed.ncbi.nlm.nih.gov/14553829 DM4UL1G DI DM4UL1G DM4UL1G DN Oxindole 95 DM4UL1G MI TT7HF4W DM4UL1G MN Cyclin-dependent kinase 2 (CDK2) DM4UL1G MT DTT DM4UL1G MA Inhibitor DM4UL1G RN Pharmacological inhibitors of cyclin-dependent kinases. Trends Pharmacol Sci. 2002 Sep;23(9):417-25. DM4UL1G RU https://pubmed.ncbi.nlm.nih.gov/12237154 DM4UL1G DI DM4UL1G DM4UL1G DN Oxindole 95 DM4UL1G MI TTL4Q97 DM4UL1G MN Cyclin-dependent kinase 5 (CDK5) DM4UL1G MT DTT DM4UL1G MA Inhibitor DM4UL1G RN Pharmacological inhibitors of cyclin-dependent kinases. Trends Pharmacol Sci. 2002 Sep;23(9):417-25. DM4UL1G RU https://pubmed.ncbi.nlm.nih.gov/12237154 DM1AU8V DI DM1AU8V DM1AU8V DN Oxindole derivative DM1AU8V MI TTSFWA7 DM1AU8V MN Plasmodium CDK Pfmrk (Malaria Pfmrk) DM1AU8V MT DTT DM1AU8V MA Inhibitor DM1AU8V RN Novel molecular targets for antimalarial chemotherapy. Int J Antimicrob Agents. 2007 Jul;30(1):4-10. DM1AU8V RU https://pubmed.ncbi.nlm.nih.gov/17339102 DMV0KTW DI DMV0KTW DMV0KTW DN oxo-arpromidine DMV0KTW MI TTTIBOJ DMV0KTW MN Histamine H1 receptor (H1R) DMV0KTW MT DTT DMV0KTW MA Agonist DMV0KTW RN Probing ligand-specific histamine H1- and H2-receptor conformations with NG-acylated Imidazolylpropylguanidines. J Pharmacol Exp Ther. 2006 Apr;317(1):139-46. DMV0KTW RU https://pubmed.ncbi.nlm.nih.gov/16394198 DMV0KTW DI DMV0KTW DMV0KTW DN oxo-arpromidine DMV0KTW MI TTQHJ1K DMV0KTW MN Histamine H2 receptor (H2R) DMV0KTW MT DTT DMV0KTW MA Agonist DMV0KTW RN Probing ligand-specific histamine H1- and H2-receptor conformations with NG-acylated Imidazolylpropylguanidines. J Pharmacol Exp Ther. 2006 Apr;317(1):139-46. DMV0KTW RU https://pubmed.ncbi.nlm.nih.gov/16394198 DMRKA08 DI DMRKA08 DMRKA08 DN Oxolithocholic acid DMRKA08 MI DEL5PTS DMRKA08 MN Alpha-hydroxysteroid dehydrogenase (12AH) DMRKA08 MT DME DMRKA08 MA Metabolism DMRKA08 RN Metabolism of oxo-bile acids and characterization of recombinant 12alpha-hydroxysteroid dehydrogenases from bile acid 7alpha-dehydroxylating human gut bacteria. Appl Environ Microbiol. 2018 May 1;84(10). pii: e00235-18. DMRKA08 RU https://pubmed.ncbi.nlm.nih.gov/29549099 DMRKA08 DI DMRKA08 DMRKA08 DN Oxolithocholic acid DMRKA08 MI DEOIYWD DMRKA08 MN Alpha-hydroxysteroid dehydrogenase (12AH) DMRKA08 MT DME DMRKA08 MA Metabolism DMRKA08 RN Metabolism of oxo-bile acids and characterization of recombinant 12alpha-hydroxysteroid dehydrogenases from bile acid 7alpha-dehydroxylating human gut bacteria. Appl Environ Microbiol. 2018 May 1;84(10). pii: e00235-18. DMRKA08 RU https://pubmed.ncbi.nlm.nih.gov/29549099 DMRKA08 DI DMRKA08 DMRKA08 DN Oxolithocholic acid DMRKA08 MI DER7IAK DMRKA08 MN Alpha-hydroxysteroid dehydrogenase (12AH) DMRKA08 MT DME DMRKA08 MA Metabolism DMRKA08 RN Metabolism of oxo-bile acids and characterization of recombinant 12alpha-hydroxysteroid dehydrogenases from bile acid 7alpha-dehydroxylating human gut bacteria. Appl Environ Microbiol. 2018 May 1;84(10). pii: e00235-18. DMRKA08 RU https://pubmed.ncbi.nlm.nih.gov/29549099 DMRKA08 DI DMRKA08 DMRKA08 DN Oxolithocholic acid DMRKA08 MI DE5Q9XD DMRKA08 MN Alpha-hydroxysteroid dehydrogenase (12AH) DMRKA08 MT DME DMRKA08 MA Metabolism DMRKA08 RN Metabolism of oxo-bile acids and characterization of recombinant 12alpha-hydroxysteroid dehydrogenases from bile acid 7alpha-dehydroxylating human gut bacteria. Appl Environ Microbiol. 2018 May 1;84(10). pii: e00235-18. DMRKA08 RU https://pubmed.ncbi.nlm.nih.gov/29549099 DMMZYX6 DI DMMZYX6 DMMZYX6 DN OXYBENZONE DMMZYX6 MI TTLUQ8E DMMZYX6 MN Hormone sensitive lipase (LIPE) DMMZYX6 MT DTT DMMZYX6 MA Inhibitor DMMZYX6 RN Combining ligand-based pharmacophore modeling, quantitative structure-activity relationship analysis and in silico screening for the discovery of n... J Med Chem. 2008 Oct 23;51(20):6478-94. DMMZYX6 RU https://pubmed.ncbi.nlm.nih.gov/18808096 DMJPBAX DI DMJPBAX DMJPBAX DN Oxybutynine DMJPBAX MI TTQ13Z5 DMJPBAX MN Muscarinic acetylcholine receptor M3 (CHRM3) DMJPBAX MT DTT DMJPBAX MA Antagonist DMJPBAX RN Generation of an agonistic binding site for blockers of the M(3) muscarinic acetylcholine receptor. Biochem J. 2008 May 15;412(1):103-12. DMJPBAX RU https://pubmed.ncbi.nlm.nih.gov/18237275 DMTP4S2 DI DMTP4S2 DMTP4S2 DN OXYMORPHINDOLE DMTP4S2 MI TT27RFC DMTP4S2 MN Opioid receptor delta (OPRD1) DMTP4S2 MT DTT DMTP4S2 MA Inhibitor DMTP4S2 RN Ligand binding to nucleic acids and proteins: Does selectivity increase with strength Eur J Med Chem. 2008 Nov;43(11):2307-15. DMTP4S2 RU https://pubmed.ncbi.nlm.nih.gov/18403056 DMTP4S2 DI DMTP4S2 DMTP4S2 DN OXYMORPHINDOLE DMTP4S2 MI TTQW87Y DMTP4S2 MN Opioid receptor kappa (OPRK1) DMTP4S2 MT DTT DMTP4S2 MA Inhibitor DMTP4S2 RN Ligand binding to nucleic acids and proteins: Does selectivity increase with strength Eur J Med Chem. 2008 Nov;43(11):2307-15. DMTP4S2 RU https://pubmed.ncbi.nlm.nih.gov/18403056 DMTP4S2 DI DMTP4S2 DMTP4S2 DN OXYMORPHINDOLE DMTP4S2 MI TTKWM86 DMTP4S2 MN Opioid receptor mu (MOP) DMTP4S2 MT DTT DMTP4S2 MA Inhibitor DMTP4S2 RN Ligand binding to nucleic acids and proteins: Does selectivity increase with strength Eur J Med Chem. 2008 Nov;43(11):2307-15. DMTP4S2 RU https://pubmed.ncbi.nlm.nih.gov/18403056 DMTSM61 DI DMTSM61 DMTSM61 DN Oxymorphone semicarbazone hydrochloride DMTSM61 MI TTQW87Y DMTSM61 MN Opioid receptor kappa (OPRK1) DMTSM61 MT DTT DMTSM61 MA Inhibitor DMTSM61 RN Peptides as receptor selectivity modulators of opiate pharmacophores. J Med Chem. 1986 Jul;29(7):1222-5. DMTSM61 RU https://pubmed.ncbi.nlm.nih.gov/2879914 DMTSM61 DI DMTSM61 DMTSM61 DN Oxymorphone semicarbazone hydrochloride DMTSM61 MI TTKWM86 DMTSM61 MN Opioid receptor mu (MOP) DMTSM61 MT DTT DMTSM61 MA Inhibitor DMTSM61 RN Peptides as receptor selectivity modulators of opiate pharmacophores. J Med Chem. 1986 Jul;29(7):1222-5. DMTSM61 RU https://pubmed.ncbi.nlm.nih.gov/2879914 DMZVS9Y DI DMZVS9Y DMZVS9Y DN OXYQUINOLINE DMZVS9Y MI TTZL0OI DMZVS9Y MN Methionine aminopeptidase 2 (METAP2) DMZVS9Y MT DTT DMZVS9Y MA Inhibitor DMZVS9Y RN Subtype-selectivity of metal-dependent methionine aminopeptidase inhibitors, Bioorg. Med. Chem. Lett. 20(14):4038-4044 (2010). DMZVS9Y RU http://www.sciencedirect.com/science/article/pii/S0960894X10007468 DMN7S4L DI DMN7S4L DMN7S4L DN OXYRESVERATROL DMN7S4L MI TTULVH8 DMN7S4L MN Tyrosinase (TYR) DMN7S4L MT DTT DMN7S4L MA Inhibitor DMN7S4L RN Chemical transformations of oxyresveratrol (trans-2,4,3',5'-tetrahydroxystilbene) into a potent tyrosinase inhibitor and a strong cytotoxic agent. Bioorg Med Chem Lett. 2006 Nov 1;16(21):5650-3. DMN7S4L RU https://pubmed.ncbi.nlm.nih.gov/16919455 DMOY627 DI DMOY627 DMOY627 DN P(1)-(6-Hydroxymethylpterin)-P(4)-(5'-adenosyl)tetraphosphate DMOY627 MI TT38ECI DMOY627 MN Bacterial Hydroxymethyl-dihydropterin pyrophosphokinase (Bact folK) DMOY627 MT DTT DMOY627 MA Inhibitor DMOY627 RN Bisubstrate analogue inhibitors of 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase: synthesis and biochemical and crystallographic studies. J Med Chem. 2001 Apr 26;44(9):1364-71. DMOY627 RU https://pubmed.ncbi.nlm.nih.gov/11311059 DMJ0W43 DI DMJ0W43 DMJ0W43 DN P-(2'-Iodo-5'-Thenoyl)Hydrotropic Acid DMJ0W43 MI TT8NGED DMJ0W43 MN Prostaglandin G/H synthase 1 (COX-1) DMJ0W43 MT DTT DMJ0W43 MA Inhibitor DMJ0W43 RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DMJ0W43 RU https://pubmed.ncbi.nlm.nih.gov/10592235 DM9SNFX DI DM9SNFX DM9SNFX DN p-[18F]MPPF DM9SNFX MI TTSQIFT DM9SNFX MN 5-HT 1A receptor (HTR1A) DM9SNFX MT DTT DM9SNFX MA Antagonist DM9SNFX RN A 18F-MPPF PET normative database of 5-HT1A receptor binding in men and women over aging. J Nucl Med. 2005 Dec;46(12):1980-9. DM9SNFX RU https://pubmed.ncbi.nlm.nih.gov/16330560 DMM4VWD DI DMM4VWD DMM4VWD DN P1-(5'-Adenosyl)P5-(5'-Thymidyl)Pentaphosphate DMM4VWD MI TT5B8AX DMM4VWD MN Mycobacterium Thymidine monophosphate kinase (MycB tmk) DMM4VWD MT DTT DMM4VWD MA Inhibitor DMM4VWD RN DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Nucleic Acids Res. 2011 Jan;39(Database issue):D1035-41. DMM4VWD RU https://pubmed.ncbi.nlm.nih.gov/21059682 DMM4VWD DI DMM4VWD DMM4VWD DN P1-(5'-Adenosyl)P5-(5'-Thymidyl)Pentaphosphate DMM4VWD MI TTP3QRF DMM4VWD MN Thymidine kinase 1 (TK1) DMM4VWD MT DTT DMM4VWD MA Inhibitor DMM4VWD RN DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Nucleic Acids Res. 2011 Jan;39(Database issue):D1035-41. DMM4VWD RU https://pubmed.ncbi.nlm.nih.gov/21059682 DMQ6TZE DI DMQ6TZE DMQ6TZE DN P-1116 DMQ6TZE MI TTAUX24 DMQ6TZE MN Erythropoietin Receptor (EPOR) DMQ6TZE MT DTT DMQ6TZE MA Stimulator DMQ6TZE RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1718). DMQ6TZE RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1718 DMETL3Z DI DMETL3Z DMETL3Z DN P2,P3 Ketoamide derivative DMETL3Z MI TTDZN01 DMETL3Z MN Cathepsin K (CTSK) DMETL3Z MT DTT DMETL3Z MA Inhibitor DMETL3Z RN Potent and selective P2-P3 ketoamide inhibitors of cathepsin K with good pharmacokinetic properties via favorable P1', P1, and/or P3 substitutions. Bioorg Med Chem Lett. 2004 Oct 4;14(19):4897-902. DMETL3Z RU https://pubmed.ncbi.nlm.nih.gov/15341947 DMETL3Z DI DMETL3Z DMETL3Z DN P2,P3 Ketoamide derivative DMETL3Z MI TTUMQVO DMETL3Z MN Cathepsin S (CTSS) DMETL3Z MT DTT DMETL3Z MA Inhibitor DMETL3Z RN Potent and selective P2-P3 ketoamide inhibitors of cathepsin K with good pharmacokinetic properties via favorable P1', P1, and/or P3 substitutions. Bioorg Med Chem Lett. 2004 Oct 4;14(19):4897-902. DMETL3Z RU https://pubmed.ncbi.nlm.nih.gov/15341947 DMZI8QW DI DMZI8QW DMZI8QW DN P-2281 DMZI8QW MI TTCJG29 DMZI8QW MN Serine/threonine-protein kinase mTOR (mTOR) DMZI8QW MT DTT DMZI8QW MA Inhibitor DMZI8QW RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2109). DMZI8QW RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2109 DMJDI7O DI DMJDI7O DMJDI7O DN P-6915 DMJDI7O MI TTHBTOP DMJDI7O MN PI3-kinase gamma (PIK3CG) DMJDI7O MT DTT DMJDI7O MA Inhibitor DMJDI7O RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2155). DMJDI7O RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2155 DMJDI7O DI DMJDI7O DMJDI7O DN P-6915 DMJDI7O MI TTCJG29 DMJDI7O MN Serine/threonine-protein kinase mTOR (mTOR) DMJDI7O MT DTT DMJDI7O MA Inhibitor DMJDI7O RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2109). DMJDI7O RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2109 DMELTM2 DI DMELTM2 DMELTM2 DN PA-10040 DMELTM2 MI TTF1QVM DMELTM2 MN Gastric H(+)/K(+) ATPase alpha (ATP4A) DMELTM2 MT DTT DMELTM2 MA Modulator DMELTM2 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 849). DMELTM2 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=849 DMUH203 DI DMUH203 DMUH203 DN PA-1637 DMUH203 MI TTE4KHA DMUH203 MN Amyloid beta A4 protein (APP) DMUH203 MT DTT DMUH203 MA Modulator DMUH203 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2402). DMUH203 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2402 DMTGZ3E DI DMTGZ3E DMTGZ3E DN PA451 DMTGZ3E MI TT6PEUO DMTGZ3E MN Retinoic acid receptor RXR-alpha (RXRA) DMTGZ3E MT DTT DMTGZ3E MA Antagonist DMTGZ3E RN Novel retinoid X receptor antagonists: specific inhibition of retinoid synergism in RXR-RAR heterodimer actions. J Med Chem. 2002 Aug 1;45(16):3327-30. DMTGZ3E RU https://pubmed.ncbi.nlm.nih.gov/12139443 DMKL6IC DI DMKL6IC DMKL6IC DN PAC-10649 DMKL6IC MI TTVKILB DMKL6IC MN Prostaglandin G/H synthase 2 (COX-2) DMKL6IC MT DTT DMKL6IC MA Inhibitor DMKL6IC RN PAC 10649 Pacific licensing offer, Worldwide excluding South Korea. R & D Focus Drug News. September 22, 2003. DMKL6IC RU http://business.highbeam.com/436989/article-1G1-107911540/pac-10649-pacific-licensing-offer-worldwide-excluding DMB26IK DI DMB26IK DMB26IK DN PACAP-27 DMB26IK MI TT4O5P0 DMB26IK MN Helodermin-preferring VIP receptor (VIPR2) DMB26IK MT DTT DMB26IK MA Agonist DMB26IK RN A systematic comparison of intracellular cyclic AMP and calcium signalling highlights complexities in human VPAC/PAC receptor pharmacology. Neuropharmacology. 2006 Nov;51(6):1086-98. DMB26IK RU https://pubmed.ncbi.nlm.nih.gov/16930633 DMB26IK DI DMB26IK DMB26IK DN PACAP-27 DMB26IK MI TT5OREU DMB26IK MN PACAP type I receptor (PAC1R) DMB26IK MT DTT DMB26IK MA Agonist DMB26IK RN A systematic comparison of intracellular cyclic AMP and calcium signalling highlights complexities in human VPAC/PAC receptor pharmacology. Neuropharmacology. 2006 Nov;51(6):1086-98. DMB26IK RU https://pubmed.ncbi.nlm.nih.gov/16930633 DMB26IK DI DMB26IK DMB26IK DN PACAP-27 DMB26IK MI TTCL30I DMB26IK MN Vasoactive intestinal polypeptide receptor 1 (VIPR1) DMB26IK MT DTT DMB26IK MA Agonist DMB26IK RN A systematic comparison of intracellular cyclic AMP and calcium signalling highlights complexities in human VPAC/PAC receptor pharmacology. Neuropharmacology. 2006 Nov;51(6):1086-98. DMB26IK RU https://pubmed.ncbi.nlm.nih.gov/16930633 DMJ5TAU DI DMJ5TAU DMJ5TAU DN Paeoniflorin DMJ5TAU MI TTK25J1 DMJ5TAU MN Adenosine A1 receptor (ADORA1) DMJ5TAU MT DTT DMJ5TAU MA Modulator DMJ5TAU RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 18). DMJ5TAU RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=18 DMRZAQW DI DMRZAQW DMRZAQW DN PAF DMRZAQW MI TTQL5VC DMRZAQW MN Platelet-activating factor receptor (PTAFR) DMRZAQW MT DTT DMRZAQW MA Agonist DMRZAQW RN Identification of transmembrane domain residues determinant in the structure-function relationship of the human platelet-activating factor receptor by site-directed mutagenesis. J Biol Chem. 1996 Sep20;271(38):23298-303. DMRZAQW RU https://pubmed.ncbi.nlm.nih.gov/8798529 DMDTP1R DI DMDTP1R DMDTP1R DN PALASONIN DMDTP1R MI TTFLH0E DMDTP1R MN Serine/threonine PP1-alpha (PPP1CA) DMDTP1R MT DTT DMDTP1R MA Inhibitor DMDTP1R RN Serine-threonine protein phosphatase inhibitors: development of potential therapeutic strategies. J Med Chem. 2002 Mar 14;45(6):1151-75. DMDTP1R RU https://pubmed.ncbi.nlm.nih.gov/11881984 DMN97BF DI DMN97BF DMN97BF DN PALBINONE DMN97BF MI TTFBNVI DMN97BF MN Aldose reductase (AKR1B1) DMN97BF MT DTT DMN97BF MA Inhibitor DMN97BF RN Inhibitors of aldose reductase and formation of advanced glycation end-products in moutan cortex (Paeonia suffruticosa). J Nat Prod. 2009 Aug;72(8):1465-70. DMN97BF RU https://pubmed.ncbi.nlm.nih.gov/19670875 DMJCOKV DI DMJCOKV DMJCOKV DN PALMATINE DMJCOKV MI TTXV4FI DMJCOKV MN Albendazole monooxygenase (CYP3A4) DMJCOKV MT DTT DMJCOKV MA Inhibitor DMJCOKV RN Cytochrome P3A4 inhibitors and other constituents of Fibraurea tinctoria. J Nat Prod. 2007 Dec;70(12):1930-3. DMJCOKV RU https://pubmed.ncbi.nlm.nih.gov/17994701 DM4W5X8 DI DM4W5X8 DM4W5X8 DN Palmitoleic Acid DM4W5X8 MI TT0OFWN DM4W5X8 MN Pseudomonas UDP-3-O-acyl-GlcNAc deacetylase (Pseudo lpxC) DM4W5X8 MT DTT DM4W5X8 MA Inhibitor DM4W5X8 RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DM4W5X8 RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMKLVSO DI DMKLVSO DMKLVSO DN Palodesangren C DMKLVSO MI TTS64P2 DMKLVSO MN Androgen receptor (AR) DMKLVSO MT DTT DMKLVSO MA Inhibitor DMKLVSO RN Antiandrogenic natural Diels--Alder-type adducts from Brosimum rubescens. J Nat Prod. 1997 Oct;60(10):997-1002. DMKLVSO RU https://pubmed.ncbi.nlm.nih.gov/9358642 DMY6NRC DI DMY6NRC DMY6NRC DN Palodesangren D DMY6NRC MI TTS64P2 DMY6NRC MN Androgen receptor (AR) DMY6NRC MT DTT DMY6NRC MA Inhibitor DMY6NRC RN Antiandrogenic natural Diels--Alder-type adducts from Brosimum rubescens. J Nat Prod. 1997 Oct;60(10):997-1002. DMY6NRC RU https://pubmed.ncbi.nlm.nih.gov/9358642 DMUEK1N DI DMUEK1N DMUEK1N DN Palodesangren E DMUEK1N MI TTS64P2 DMUEK1N MN Androgen receptor (AR) DMUEK1N MT DTT DMUEK1N MA Inhibitor DMUEK1N RN Antiandrogenic natural Diels--Alder-type adducts from Brosimum rubescens. J Nat Prod. 1997 Oct;60(10):997-1002. DMUEK1N RU https://pubmed.ncbi.nlm.nih.gov/9358642 DM7M5AF DI DM7M5AF DM7M5AF DN pamoic acid DM7M5AF MI TT254XD DM7M5AF MN Kynurenic acid receptor (GPR35) DM7M5AF MT DTT DM7M5AF MA Agonist DM7M5AF RN Identification of novel species-selective agonists of the G-protein-coupled receptor GPR35 that promote recruitment of beta-arrestin-2 and activate Galpha13. Biochem J. 2010 Dec 15;432(3):451-9. DM7M5AF RU https://pubmed.ncbi.nlm.nih.gov/20919992 DM8HWS9 DI DM8HWS9 DM8HWS9 DN P-Anisic Acid DM8HWS9 MI TT9V5JH DM8HWS9 MN Phospholipase A2 (PLA2G1B) DM8HWS9 MT DTT DM8HWS9 MA Inhibitor DM8HWS9 RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DM8HWS9 RU https://pubmed.ncbi.nlm.nih.gov/17139284 DM2JUTB DI DM2JUTB DM2JUTB DN PARA-(BENZOYL)-PHENYLALANINE DM2JUTB MI TTELIN2 DM2JUTB MN PTPN1 messenger RNA (PTPN1 mRNA) DM2JUTB MT DTT DM2JUTB MA Inhibitor DM2JUTB RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DM2JUTB RU https://pubmed.ncbi.nlm.nih.gov/10592235 DMOH75D DI DMOH75D DMOH75D DN Para-chloroamphetamine DMOH75D MI TTVBI8W DMOH75D MN Dopamine transporter (DAT) DMOH75D MT DTT DMOH75D MA Inhibitor DMOH75D RN Synthesis and serotonin transporter activity of sulphur-substituted alpha-alkyl phenethylamines as a new class of anticancer agents. Eur J Med Chem. 2009 Dec;44(12):4862-88. DMOH75D RU https://pubmed.ncbi.nlm.nih.gov/19717215 DMOH75D DI DMOH75D DMOH75D DN Para-chloroamphetamine DMOH75D MI TTAWNKZ DMOH75D MN Norepinephrine transporter (NET) DMOH75D MT DTT DMOH75D MA Inhibitor DMOH75D RN Synthesis and serotonin transporter activity of sulphur-substituted alpha-alkyl phenethylamines as a new class of anticancer agents. Eur J Med Chem. 2009 Dec;44(12):4862-88. DMOH75D RU https://pubmed.ncbi.nlm.nih.gov/19717215 DMOH75D DI DMOH75D DMOH75D DN Para-chloroamphetamine DMOH75D MI TT3ROYC DMOH75D MN Serotonin transporter (SERT) DMOH75D MT DTT DMOH75D MA Inhibitor DMOH75D RN Synthesis and serotonin transporter activity of sulphur-substituted alpha-alkyl phenethylamines as a new class of anticancer agents. Eur J Med Chem. 2009 Dec;44(12):4862-88. DMOH75D RU https://pubmed.ncbi.nlm.nih.gov/19717215 DMZY41U DI DMZY41U DMZY41U DN Para-Isopropylaniline DMZY41U MI TT3NKIB DMZY41U MN Pancreatic elastase 1 (CELA1) DMZY41U MT DTT DMZY41U MA Inhibitor DMZY41U RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMZY41U RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMQVFWJ DI DMQVFWJ DMQVFWJ DN Para-Mercury-Benzenesulfonic Acid DMQVFWJ MI TTOM3J0 DMQVFWJ MN Estrogen receptor beta (ESR2) DMQVFWJ MT DTT DMQVFWJ MA Inhibitor DMQVFWJ RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMQVFWJ RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMN4ZKC DI DMN4ZKC DMN4ZKC DN Paraoxon DMN4ZKC MI TT1RS9F DMN4ZKC MN Acetylcholinesterase (AChE) DMN4ZKC MT DTT DMN4ZKC MA Inhibitor DMN4ZKC RN Activation of the endocannabinoid system by organophosphorus nerve agents. Nat Chem Biol. 2008 Jun;4(6):373-8. DMN4ZKC RU https://pubmed.ncbi.nlm.nih.gov/18438404 DMN4ZKC DI DMN4ZKC DMN4ZKC DN Paraoxon DMN4ZKC MI TT6OEDT DMN4ZKC MN Cannabinoid receptor 1 (CB1) DMN4ZKC MT DTT DMN4ZKC MA Inhibitor DMN4ZKC RN Monoacylglycerol lipase regulates 2-arachidonoylglycerol action and arachidonic acid levels. Bioorg Med Chem Lett. 2008 Nov 15;18(22):5875-8. DMN4ZKC RU https://pubmed.ncbi.nlm.nih.gov/18752948 DMN4ZKC DI DMN4ZKC DMN4ZKC DN Paraoxon DMN4ZKC MI TTUNARX DMN4ZKC MN Carbonic anhydrase (CA) DMN4ZKC MT DTT DMN4ZKC MA Inhibitor DMN4ZKC RN Paraoxon, 4-nitrophenyl phosphate and acetate are substrates of - but not of -, - and -carbonic anhydrases. Bioorg Med Chem Lett. 2010 Nov 1;20(21):6208-12. DMN4ZKC RU https://pubmed.ncbi.nlm.nih.gov/20833546 DMN4ZKC DI DMN4ZKC DMN4ZKC DN Paraoxon DMN4ZKC MI TTHQPL7 DMN4ZKC MN Carbonic anhydrase I (CA-I) DMN4ZKC MT DTT DMN4ZKC MA Inhibitor DMN4ZKC RN Paraoxon, 4-nitrophenyl phosphate and acetate are substrates of - but not of -, - and -carbonic anhydrases. Bioorg Med Chem Lett. 2010 Nov 1;20(21):6208-12. DMN4ZKC RU https://pubmed.ncbi.nlm.nih.gov/20833546 DMN4ZKC DI DMN4ZKC DMN4ZKC DN Paraoxon DMN4ZKC MI TTANPDJ DMN4ZKC MN Carbonic anhydrase II (CA-II) DMN4ZKC MT DTT DMN4ZKC MA Inhibitor DMN4ZKC RN Paraoxon, 4-nitrophenyl phosphate and acetate are substrates of - but not of -, - and -carbonic anhydrases. Bioorg Med Chem Lett. 2010 Nov 1;20(21):6208-12. DMN4ZKC RU https://pubmed.ncbi.nlm.nih.gov/20833546 DMN4ZKC DI DMN4ZKC DMN4ZKC DN Paraoxon DMN4ZKC MI DEJGDUW DMN4ZKC MN Cytochrome P450 1A2 (CYP1A2) DMN4ZKC MT DME DMN4ZKC MA Metabolism DMN4ZKC RN Diazinon, chlorpyrifos and parathion are metabolised by multiple cytochromes P450 in human liver. Toxicology. 2006 Jul 5;224(1-2):22-32. DMN4ZKC RU https://www.ncbi.nlm.nih.gov/pubmed/?term=16757081 DMN4ZKC DI DMN4ZKC DMN4ZKC DN Paraoxon DMN4ZKC MI DES5XRU DMN4ZKC MN Cytochrome P450 2C8 (CYP2C8) DMN4ZKC MT DME DMN4ZKC MA Metabolism DMN4ZKC RN Diazinon, chlorpyrifos and parathion are metabolised by multiple cytochromes P450 in human liver. Toxicology. 2006 Jul 5;224(1-2):22-32. DMN4ZKC RU https://www.ncbi.nlm.nih.gov/pubmed/?term=16757081 DMN4ZKC DI DMN4ZKC DMN4ZKC DN Paraoxon DMN4ZKC MI DEVDYN7 DMN4ZKC MN Cytochrome P450 2E1 (CYP2E1) DMN4ZKC MT DME DMN4ZKC MA Metabolism DMN4ZKC RN Interaction of ethanol and the organophosphorus insecticide parathion. Biochem Pharmacol. 1995 Nov 27;50(11):1925-32. DMN4ZKC RU https://www.ncbi.nlm.nih.gov/pubmed/?term=8615874 DMN4ZKC DI DMN4ZKC DMN4ZKC DN Paraoxon DMN4ZKC MI DE4LYSA DMN4ZKC MN Cytochrome P450 3A4 (CYP3A4) DMN4ZKC MT DME DMN4ZKC MA Metabolism DMN4ZKC RN Diazinon, chlorpyrifos and parathion are metabolised by multiple cytochromes P450 in human liver. Toxicology. 2006 Jul 5;224(1-2):22-32. DMN4ZKC RU https://www.ncbi.nlm.nih.gov/pubmed/?term=16757081 DMN4ZKC DI DMN4ZKC DMN4ZKC DN Paraoxon DMN4ZKC MI DEIBDNY DMN4ZKC MN Cytochrome P450 3A5 (CYP3A5) DMN4ZKC MT DME DMN4ZKC MA Metabolism DMN4ZKC RN Diazinon, chlorpyrifos and parathion are metabolised by multiple cytochromes P450 in human liver. Toxicology. 2006 Jul 5;224(1-2):22-32. DMN4ZKC RU https://www.ncbi.nlm.nih.gov/pubmed/?term=16757081 DMN4ZKC DI DMN4ZKC DMN4ZKC DN Paraoxon DMN4ZKC MI TTDP1UC DMN4ZKC MN Fatty acid amide hydrolase (FAAH) DMN4ZKC MT DTT DMN4ZKC MA Inhibitor DMN4ZKC RN Activation of the endocannabinoid system by organophosphorus nerve agents. Nat Chem Biol. 2008 Jun;4(6):373-8. DMN4ZKC RU https://pubmed.ncbi.nlm.nih.gov/18438404 DMN4ZKC DI DMN4ZKC DMN4ZKC DN Paraoxon DMN4ZKC MI DESDN74 DMN4ZKC MN Serum paraoxonase/arylesterase 1 (PON1) DMN4ZKC MT DME DMN4ZKC MA Metabolism DMN4ZKC RN Human serum paraoxonase (PON1) isozymes Q and R hydrolyze lactones and cyclic carbonate esters. Drug Metab Dispos. 2000 Nov;28(11):1335-42. DMN4ZKC RU https://www.ncbi.nlm.nih.gov/pubmed/?term=11038162 DMN4ZKC DI DMN4ZKC DMN4ZKC DN Paraoxon DMN4ZKC MI DEHJU7E DMN4ZKC MN Serum paraoxonase/arylesterase 2 (PON2) DMN4ZKC MT DME DMN4ZKC MA Metabolism DMN4ZKC RN Paraoxonases-1, -2 and -3: what are their functions? Chem Biol Interact. 2016 Nov 25;259(Pt B):51-62. DMN4ZKC RU https://www.ncbi.nlm.nih.gov/pubmed/?term=27238723 DMR8O3X DI DMR8O3X DMR8O3X DN Paraquat DMR8O3X MI DTZGT0P DMR8O3X MN Multidrug and toxin extrusion protein 1 (SLC47A1) DMR8O3X MT DTP DMR8O3X MA Substrate DMR8O3X RN Genetic variants in multidrug and toxic compound extrusion-1, hMATE1, alter transport function. Pharmacogenomics J. 2009 Apr;9(2):127-36. DMR8O3X RU http://www.ncbi.nlm.nih.gov/pubmed/19172157 DMR8O3X DI DMR8O3X DMR8O3X DN Paraquat DMR8O3X MI DTUGYRD DMR8O3X MN P-glycoprotein 1 (ABCB1) DMR8O3X MT DTP DMR8O3X MA Substrate DMR8O3X RN Mammalian drug efflux transporters of the ATP binding cassette (ABC) family in multidrug resistance: A review of the past decade. Cancer Lett. 2016 Jan 1;370(1):153-64. DMR8O3X RU http://www.ncbi.nlm.nih.gov/pubmed/26499806 DM83C9N DI DM83C9N DM83C9N DN Para-sirtinol DM83C9N MI TTUF2HO DM83C9N MN NAD-dependent deacetylase sirtuin-1 (SIRT1) DM83C9N MT DTT DM83C9N MA Inhibitor DM83C9N RN Design, synthesis, and biological evaluation of sirtinol analogues as class III histone/protein deacetylase (Sirtuin) inhibitors. J Med Chem. 2005 Dec 1;48(24):7789-95. DM83C9N RU https://pubmed.ncbi.nlm.nih.gov/16302818 DMKJY3U DI DMKJY3U DMKJY3U DN parathyroid hormone DMKJY3U MI TT6F7GZ DMKJY3U MN Parathyroid hormone (PTH) DMKJY3U MT DTT DMKJY3U MA Modulator DMKJY3U RN Daily parathyroid hormone 1-34 replacement therapy for hypoparathyroidism induces marked changes in bone turnover and structure.J Bone Miner Res.2012 Aug;27(8):1811-20. DMKJY3U RU https://www.ncbi.nlm.nih.gov/pubmed/22492501 DMWVPSM DI DMWVPSM DMWVPSM DN PARCETASAL DMWVPSM MI TTGSRBC DMWVPSM MN Prostaglandin synthetase (PGS) DMWVPSM MT DTT DMWVPSM MA Modulator DMWVPSM RN Paracetamol effectively reduces prostaglandin E2 synthesis in brain macrophages by inhibiting enzymatic activity of cyclooxygenase but not phospholipase and prostaglandin E synthase. J Neurosci Res. 2003 Mar 15;71(6):844-52. DMWVPSM RU https://pubmed.ncbi.nlm.nih.gov/12605411 DMVI8R2 DI DMVI8R2 DMVI8R2 DN Parke-Davis 1 DMVI8R2 MI TTXHYV6 DMVI8R2 MN Voltage-gated L-type calcium channel (L-CaC) DMVI8R2 MT DTT DMVI8R2 MA Blocker DMVI8R2 RN Recent updates of N-type calcium channel blockers with therapeutic potential for neuropathic pain and stroke. Curr Top Med Chem. 2009;9(4):377-95. DMVI8R2 RU https://pubmed.ncbi.nlm.nih.gov/19442208 DMMQY42 DI DMMQY42 DMMQY42 DN Parke-Davis 9 DMMQY42 MI TTXHYV6 DMMQY42 MN Voltage-gated L-type calcium channel (L-CaC) DMMQY42 MT DTT DMMQY42 MA Blocker DMMQY42 RN Recent updates of N-type calcium channel blockers with therapeutic potential for neuropathic pain and stroke. Curr Top Med Chem. 2009;9(4):377-95. DMMQY42 RU https://pubmed.ncbi.nlm.nih.gov/19442208 DML8BT7 DI DML8BT7 DML8BT7 DN PAS219 DML8BT7 MI TT6PKBN DML8BT7 MN Proto-oncogene c-Src (SRC) DML8BT7 MT DTT DML8BT7 MA Inhibitor DML8BT7 RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DML8BT7 RU https://pubmed.ncbi.nlm.nih.gov/10592235 DM7Y0G6 DI DM7Y0G6 DM7Y0G6 DN PASBN DM7Y0G6 MI TT6PKBN DM7Y0G6 MN Proto-oncogene c-Src (SRC) DM7Y0G6 MT DTT DM7Y0G6 MA Inhibitor DM7Y0G6 RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DM7Y0G6 RU https://pubmed.ncbi.nlm.nih.gov/10592235 DMRJ104 DI DMRJ104 DMRJ104 DN PAT5A DMRJ104 MI TTT2SVW DMRJ104 MN PPAR-gamma messenger RNA (PPARG mRNA) DMRJ104 MT DTT DMRJ104 MA Agonist DMRJ104 RN Euglycemic and hypolipidemic activity of PAT5A: a unique thiazolidinedione with weak peroxisome proliferator activated receptor gamma activity. Metabolism. 2000 Nov;49(11):1417-23. DMRJ104 RU https://pubmed.ncbi.nlm.nih.gov/11092504 DMOXNYQ DI DMOXNYQ DMOXNYQ DN Patuletin 3-O-beta-D-galactoside DMOXNYQ MI TTFBNVI DMOXNYQ MN Aldose reductase (AKR1B1) DMOXNYQ MT DTT DMOXNYQ MA Inhibitor DMOXNYQ RN Flavonoids with anti-cataract activity from Brickellia arguta. J Nat Prod. 1984 Mar-Apr;47(2):316-9. DMOXNYQ RU https://pubmed.ncbi.nlm.nih.gov/6429283 DMZ5Q7J DI DMZ5Q7J DMZ5Q7J DN Patuletin 3-O-beta-D-robinobioside DMZ5Q7J MI TTFBNVI DMZ5Q7J MN Aldose reductase (AKR1B1) DMZ5Q7J MT DTT DMZ5Q7J MA Inhibitor DMZ5Q7J RN Flavonoids with anti-cataract activity from Brickellia arguta. J Nat Prod. 1984 Mar-Apr;47(2):316-9. DMZ5Q7J RU https://pubmed.ncbi.nlm.nih.gov/6429283 DM0RV9C DI DM0RV9C DM0RV9C DN PATULIN DM0RV9C MI TTWXB3E DM0RV9C MN Hepatitis C virus NS3 helicase (HCV NS3) DM0RV9C MT DTT DM0RV9C MA Inhibitor DM0RV9C RN Control of hepatitis C: a medicinal chemistry perspective. J Med Chem. 2005 Jan 13;48(1):1-20. DM0RV9C RU https://pubmed.ncbi.nlm.nih.gov/15633995 DMQA8N3 DI DMQA8N3 DMQA8N3 DN PAULLONE DMQA8N3 MI TTRSMW9 DMQA8N3 MN Glycogen synthase kinase-3 beta (GSK-3B) DMQA8N3 MT DTT DMQA8N3 MA Inhibitor DMQA8N3 RN Discovery of potent and bioavailable GSK-3beta inhibitors. Bioorg Med Chem Lett. 2010 Mar 1;20(5):1693-6. DMQA8N3 RU https://pubmed.ncbi.nlm.nih.gov/20138512 DMPF2N1 DI DMPF2N1 DMPF2N1 DN paxilline DMPF2N1 MI TT1AQ50 DMPF2N1 MN Charybdotoxin receptor beta-4 (BKbeta4) DMPF2N1 MT DTT DMPF2N1 MA Blocker (channel blocker) DMPF2N1 RN Paxilline inhibition of the alpha-subunit of the high-conductance calcium-activated potassium channel. Neuropharmacology. 1996;35(7):963-8. DMPF2N1 RU https://pubmed.ncbi.nlm.nih.gov/8938726 DMPF2N1 DI DMPF2N1 DMPF2N1 DN paxilline DMPF2N1 MI TTECBXN DMPF2N1 MN Oxysterols receptor LXR-alpha (NR1H3) DMPF2N1 MT DTT DMPF2N1 MA Agonist DMPF2N1 RN A natural product ligand of the oxysterol receptor, liver X receptor. J Pharmacol Exp Ther. 2003 Oct;307(1):291-6. DMPF2N1 RU https://pubmed.ncbi.nlm.nih.gov/12893846 DMX7WU9 DI DMX7WU9 DMX7WU9 DN PB-1120 DMX7WU9 MI TT4O5P0 DMX7WU9 MN Helodermin-preferring VIP receptor (VIPR2) DMX7WU9 MT DTT DMX7WU9 MA Modulator DMX7WU9 RN Company report (PhaseBio) DMX7WU9 RU http://phasebio.com/clinical-development-pipeline/pb1046-pb1120/ DMZURA2 DI DMZURA2 DMZURA2 DN PB-27 DMZURA2 MI TT7WZIJ DMZURA2 MN CAAX farnesyltransferase beta (FNTB) DMZURA2 MT DTT DMZURA2 MA Inhibitor DMZURA2 RN Protein farnesyltransferase inhibitors exhibit potent antimalarial activity. J Med Chem. 2005 Jun 2;48(11):3704-13. DMZURA2 RU https://pubmed.ncbi.nlm.nih.gov/15916422 DMZURA2 DI DMZURA2 DMZURA2 DN PB-27 DMZURA2 MI TTXQKM3 DMZURA2 MN Farnesyl protein transferase (Ftase) DMZURA2 MT DTT DMZURA2 MA Inhibitor DMZURA2 RN Protein farnesyltransferase inhibitors exhibit potent antimalarial activity. J Med Chem. 2005 Jun 2;48(11):3704-13. DMZURA2 RU https://pubmed.ncbi.nlm.nih.gov/15916422 DMMNQ1B DI DMMNQ1B DMMNQ1B DN PB28 DMMNQ1B MI TTTPE1L DMMNQ1B MN HUMAN opioid receptor sigma 1 (OPRS1) DMMNQ1B MT DTT DMMNQ1B MA Modulator DMMNQ1B RN A SARS-CoV-2 protein interaction map reveals targets for drug repurposing DMMNQ1B RU https://www.nature.com/articles/s41586-020-2286-9 DMMNQ1B DI DMMNQ1B DMMNQ1B DN PB28 DMMNQ1B MI TTIS0R2 DMMNQ1B MN HUMAN sigma intracellular receptor 2 (TMEM97) DMMNQ1B MT DTT DMMNQ1B MA Modulator DMMNQ1B RN A SARS-CoV-2 protein interaction map reveals targets for drug repurposing DMMNQ1B RU https://www.nature.com/articles/s41586-020-2286-9 DMSXZ19 DI DMSXZ19 DMSXZ19 DN PB-28 DMSXZ19 MI TTSQIFT DMSXZ19 MN 5-HT 1A receptor (HTR1A) DMSXZ19 MT DTT DMSXZ19 MA Inhibitor DMSXZ19 RN New sigma and 5-HT1A receptor ligands: omega-(tetralin-1-yl)-n-alkylamine derivatives. J Med Chem. 1996 Jan 5;39(1):176-82. DMSXZ19 RU https://pubmed.ncbi.nlm.nih.gov/8568804 DMAOIW5 DI DMAOIW5 DMAOIW5 DN PB-80 DMAOIW5 MI TT7WZIJ DMAOIW5 MN CAAX farnesyltransferase beta (FNTB) DMAOIW5 MT DTT DMAOIW5 MA Inhibitor DMAOIW5 RN Protein farnesyltransferase inhibitors exhibit potent antimalarial activity. J Med Chem. 2005 Jun 2;48(11):3704-13. DMAOIW5 RU https://pubmed.ncbi.nlm.nih.gov/15916422 DMAOIW5 DI DMAOIW5 DMAOIW5 DN PB-80 DMAOIW5 MI TTXQKM3 DMAOIW5 MN Farnesyl protein transferase (Ftase) DMAOIW5 MT DTT DMAOIW5 MA Inhibitor DMAOIW5 RN Protein farnesyltransferase inhibitors exhibit potent antimalarial activity. J Med Chem. 2005 Jun 2;48(11):3704-13. DMAOIW5 RU https://pubmed.ncbi.nlm.nih.gov/15916422 DM9V807 DI DM9V807 DM9V807 DN PB-81 DM9V807 MI TT7WZIJ DM9V807 MN CAAX farnesyltransferase beta (FNTB) DM9V807 MT DTT DM9V807 MA Inhibitor DM9V807 RN Protein farnesyltransferase inhibitors exhibit potent antimalarial activity. J Med Chem. 2005 Jun 2;48(11):3704-13. DM9V807 RU https://pubmed.ncbi.nlm.nih.gov/15916422 DM9V807 DI DM9V807 DM9V807 DN PB-81 DM9V807 MI TTXQKM3 DM9V807 MN Farnesyl protein transferase (Ftase) DM9V807 MT DTT DM9V807 MA Inhibitor DM9V807 RN Protein farnesyltransferase inhibitors exhibit potent antimalarial activity. J Med Chem. 2005 Jun 2;48(11):3704-13. DM9V807 RU https://pubmed.ncbi.nlm.nih.gov/15916422 DM39LS5 DI DM39LS5 DM39LS5 DN PBC-264 DM39LS5 MI TTVFO0U DM39LS5 MN Gastrin/cholecystokinin type B receptor (CCKBR) DM39LS5 MT DTT DM39LS5 MA Agonist DM39LS5 RN His381 of the rat CCKB receptor is essential for CCKB versus CCKA receptor antagonist selectivity. Eur J Pharmacol. 1996 Jan 18;296(1):97-106. DM39LS5 RU https://pubmed.ncbi.nlm.nih.gov/8720482 DM1Y2F0 DI DM1Y2F0 DM1Y2F0 DN PBD150 DM1Y2F0 MI TTJ7YTV DM1Y2F0 MN Glutaminyl cyclase (QPCT) DM1Y2F0 MT DTT DM1Y2F0 MA Inhibitor DM1Y2F0 RN The first potent inhibitors for human glutaminyl cyclase: synthesis and structure-activity relationship. J Med Chem. 2006 Jan 26;49(2):664-77. DM1Y2F0 RU https://pubmed.ncbi.nlm.nih.gov/16420052 DM8Q54I DI DM8Q54I DM8Q54I DN PBIT DM8Q54I MI TTIG67W DM8Q54I MN Lysine-specific demethylase 5A (KDM5A) DM8Q54I MT DTT DM8Q54I MA Inhibitor DM8Q54I RN Identification of small molecule inhibitors of Jumonji AT-rich interactive domain 1B (JARID1B) histone demethylase by a sensitive high throughput screen. J Biol Chem. 2013 Mar 29;288(13):9408-17. DM8Q54I RU https://pubmed.ncbi.nlm.nih.gov/23408432 DM8Q54I DI DM8Q54I DM8Q54I DN PBIT DM8Q54I MI TTCLI75 DM8Q54I MN Lysine-specific demethylase 5B (KDM5B) DM8Q54I MT DTT DM8Q54I MA Inhibitor DM8Q54I RN Identification of small molecule inhibitors of Jumonji AT-rich interactive domain 1B (JARID1B) histone demethylase by a sensitive high throughput screen. J Biol Chem. 2013 Mar 29;288(13):9408-17. DM8Q54I RU https://pubmed.ncbi.nlm.nih.gov/23408432 DM8Q54I DI DM8Q54I DM8Q54I DN PBIT DM8Q54I MI TT94UCF DM8Q54I MN Lysine-specific demethylase 5C (KDM5C) DM8Q54I MT DTT DM8Q54I MA Inhibitor DM8Q54I RN Identification of small molecule inhibitors of Jumonji AT-rich interactive domain 1B (JARID1B) histone demethylase by a sensitive high throughput screen. J Biol Chem. 2013 Mar 29;288(13):9408-17. DM8Q54I RU https://pubmed.ncbi.nlm.nih.gov/23408432 DM8K7C4 DI DM8K7C4 DM8K7C4 DN PBMC DM8K7C4 MI TTXDKTO DM8K7C4 MN Long transient receptor potential channel 8 (TRPM8) DM8K7C4 MT DTT DM8K7C4 MA Blocker (channel blocker) DM8K7C4 RN Pharmacological blockade of TRPM8 ion channels alters cold and cold pain responses in mice. PLoS One. 2011;6(9):e25894. DM8K7C4 RU https://pubmed.ncbi.nlm.nih.gov/21984952 DMD9KYN DI DMD9KYN DMD9KYN DN PCCG-4 DMD9KYN MI TTXJ47W DMD9KYN MN Metabotropic glutamate receptor 2 (mGluR2) DMD9KYN MT DTT DMD9KYN MA Antagonist DMD9KYN RN Synthesis and pharmacological characterization of all sixteen stereoisomers of 2-(2'-carboxy-3'-phenylcyclopropyl)glycine. Focus on (2S,1'S,2'S,3'R)-2-(2'-carboxy-3'-phenylcyclopropyl)glycine, a novel and selective group II metabotropic glutamate receptors antagonist. J Med Chem. 1996 May 24;39(11):2259-69. DMD9KYN RU https://pubmed.ncbi.nlm.nih.gov/8667369 DMIMPDL DI DMIMPDL DMIMPDL DN PCI-34051 DMIMPDL MI TTT6LFV DMIMPDL MN Histone deacetylase 8 (HDAC8) DMIMPDL MT DTT DMIMPDL MA Inhibitor DMIMPDL RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2619). DMIMPDL RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2619 DMGIS5Q DI DMGIS5Q DMGIS5Q DN pCMPS DMGIS5Q MI TTZ1DT0 DMGIS5Q MN P2Y purinoceptor 12 (P2RY12) DMGIS5Q MT DTT DMGIS5Q MA Antagonist DMGIS5Q RN P2Y12, a new platelet ADP receptor, target of clopidogrel. Semin Vasc Med. 2003 May;3(2):113-22. DMGIS5Q RU https://pubmed.ncbi.nlm.nih.gov/15199474 DMGS6YH DI DMGS6YH DMGS6YH DN PCNOTAXIME GROUP DMGS6YH MI TT85JMW DMGS6YH MN Bacterial Penicillin binding protein 3 (Bact mrcA) DMGS6YH MT DTT DMGS6YH MA Inhibitor DMGS6YH RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DMGS6YH RU https://pubmed.ncbi.nlm.nih.gov/10592235 DMGS6YH DI DMGS6YH DMGS6YH DN PCNOTAXIME GROUP DMGS6YH MI TTHI19T DMGS6YH MN Staphylococcus Beta-lactamase (Stap-coc blaZ) DMGS6YH MT DTT DMGS6YH MA Inhibitor DMGS6YH RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DMGS6YH RU https://pubmed.ncbi.nlm.nih.gov/10592235 DMGJSVD DI DMGJSVD DMGJSVD DN P-Coumaric Acid DMGJSVD MI TTUNARX DMGJSVD MN Carbonic anhydrase (CA) DMGJSVD MT DTT DMGJSVD MA Inhibitor DMGJSVD RN Carbonic anhydrase inhibitors. Inhibition of mammalian isoforms I-XIV with a series of natural product polyphenols and phenolic acids. Bioorg Med Chem. 2010 Mar 15;18(6):2159-2164. DMGJSVD RU https://pubmed.ncbi.nlm.nih.gov/20185318 DMGJSVD DI DMGJSVD DMGJSVD DN P-Coumaric Acid DMGJSVD MI TTHQPL7 DMGJSVD MN Carbonic anhydrase I (CA-I) DMGJSVD MT DTT DMGJSVD MA Inhibitor DMGJSVD RN Carbonic anhydrase inhibitors. Inhibition of mammalian isoforms I-XIV with a series of natural product polyphenols and phenolic acids. Bioorg Med Chem. 2010 Mar 15;18(6):2159-2164. DMGJSVD RU https://pubmed.ncbi.nlm.nih.gov/20185318 DMGJSVD DI DMGJSVD DMGJSVD DN P-Coumaric Acid DMGJSVD MI TTANPDJ DMGJSVD MN Carbonic anhydrase II (CA-II) DMGJSVD MT DTT DMGJSVD MA Inhibitor DMGJSVD RN Carbonic anhydrase inhibitors. Inhibition of mammalian isoforms I-XIV with a series of natural product polyphenols and phenolic acids. Bioorg Med Chem. 2010 Mar 15;18(6):2159-2164. DMGJSVD RU https://pubmed.ncbi.nlm.nih.gov/20185318 DMGJSVD DI DMGJSVD DMGJSVD DN P-Coumaric Acid DMGJSVD MI TTZHA0O DMGJSVD MN Carbonic anhydrase IV (CA-IV) DMGJSVD MT DTT DMGJSVD MA Inhibitor DMGJSVD RN Carbonic anhydrase inhibitors. Inhibition of mammalian isoforms I-XIV with a series of natural product polyphenols and phenolic acids. Bioorg Med Chem. 2010 Mar 15;18(6):2159-2164. DMGJSVD RU https://pubmed.ncbi.nlm.nih.gov/20185318 DMGJSVD DI DMGJSVD DMGJSVD DN P-Coumaric Acid DMGJSVD MI TT2LVK8 DMGJSVD MN Carbonic anhydrase IX (CA-IX) DMGJSVD MT DTT DMGJSVD MA Inhibitor DMGJSVD RN Carbonic anhydrase inhibitors. Inhibition of mammalian isoforms I-XIV with a series of natural product polyphenols and phenolic acids. Bioorg Med Chem. 2010 Mar 15;18(6):2159-2164. DMGJSVD RU https://pubmed.ncbi.nlm.nih.gov/20185318 DMGJSVD DI DMGJSVD DMGJSVD DN P-Coumaric Acid DMGJSVD MI TTCFSPE DMGJSVD MN Carbonic anhydrase VI (CA-VI) DMGJSVD MT DTT DMGJSVD MA Inhibitor DMGJSVD RN Carbonic anhydrase inhibitors. Inhibition of mammalian isoforms I-XIV with a series of natural product polyphenols and phenolic acids. Bioorg Med Chem. 2010 Mar 15;18(6):2159-2164. DMGJSVD RU https://pubmed.ncbi.nlm.nih.gov/20185318 DMGJSVD DI DMGJSVD DMGJSVD DN P-Coumaric Acid DMGJSVD MI TTSYM0R DMGJSVD MN Carbonic anhydrase XII (CA-XII) DMGJSVD MT DTT DMGJSVD MA Inhibitor DMGJSVD RN Carbonic anhydrase inhibitors. Inhibition of mammalian isoforms I-XIV with a series of natural product polyphenols and phenolic acids. Bioorg Med Chem. 2010 Mar 15;18(6):2159-2164. DMGJSVD RU https://pubmed.ncbi.nlm.nih.gov/20185318 DMGJSVD DI DMGJSVD DMGJSVD DN P-Coumaric Acid DMGJSVD MI TTEYTKG DMGJSVD MN Carbonic anhydrase XIV (CA-XIV) DMGJSVD MT DTT DMGJSVD MA Inhibitor DMGJSVD RN Carbonic anhydrase inhibitors. Inhibition of mammalian isoforms I-XIV with a series of natural product polyphenols and phenolic acids. Bioorg Med Chem. 2010 Mar 15;18(6):2159-2164. DMGJSVD RU https://pubmed.ncbi.nlm.nih.gov/20185318 DMZVJYL DI DMZVJYL DMZVJYL DN PcTx1 DMZVJYL MI TTRJYB6 DMZVJYL MN Acid-sensing ion channel 1 (ASIC1) DMZVJYL MT DTT DMZVJYL MA Blocker DMZVJYL RN Challenges in analgesic drug development. Clin Pharmacol Ther. 2009 Oct;86(4):447-50. DMZVJYL RU https://pubmed.ncbi.nlm.nih.gov/19675542 DMYC51H DI DMYC51H DMYC51H DN PD 128907 DMYC51H MI TTEX248 DMYC51H MN Dopamine D2 receptor (D2R) DMYC51H MT DTT DMYC51H MA Agonist DMYC51H RN Neurochemical and functional characterization of the preferentially selective dopamine D3 agonist PD 128907. J Pharmacol Exp Ther. 1995 Dec;275(3):1355-66. DMYC51H RU https://pubmed.ncbi.nlm.nih.gov/8531103 DMYC51H DI DMYC51H DMYC51H DN PD 128907 DMYC51H MI TT4C8EA DMYC51H MN Dopamine D3 receptor (D3R) DMYC51H MT DTT DMYC51H MA Agonist DMYC51H RN Neurochemical and functional characterization of the preferentially selective dopamine D3 agonist PD 128907. J Pharmacol Exp Ther. 1995 Dec;275(3):1355-66. DMYC51H RU https://pubmed.ncbi.nlm.nih.gov/8531103 DM5GTHE DI DM5GTHE DM5GTHE DN PD 154740 DM5GTHE MI TTBPGLU DM5GTHE MN Neuromedin-K receptor (TACR3) DM5GTHE MT DTT DM5GTHE MA Antagonist DM5GTHE RN Two classes of structurally different antagonists display similar species preference for the human tachykinin neurokinin3 receptor. Mol Pharmacol. 1995 Oct;48(4):711-6. DM5GTHE RU https://pubmed.ncbi.nlm.nih.gov/7476898 DM5J4NA DI DM5J4NA DM5J4NA DN PD 165929 DM5J4NA MI TTHYDUM DM5J4NA MN Bombesin receptor (BS) DM5J4NA MT DTT DM5J4NA MA Antagonist DM5J4NA RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 38). DM5J4NA RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=38 DMFNQEA DI DMFNQEA DMFNQEA DN PD 168368 DMFNQEA MI TTHYDUM DMFNQEA MN Bombesin receptor (BS) DMFNQEA MT DTT DMFNQEA MA Antagonist DMFNQEA RN Characterization of putative GRP- and NMB-receptor antagonist's interaction with human receptors. Peptides. 2009 Aug;30(8):1473-86. DMFNQEA RU https://pubmed.ncbi.nlm.nih.gov/19463875 DMFNQEA DI DMFNQEA DMFNQEA DN PD 168368 DMFNQEA MI TTC1MVT DMFNQEA MN Gastrin-releasing peptide receptor (GRPR) DMFNQEA MT DTT DMFNQEA MA Antagonist DMFNQEA RN Comparative pharmacology of the nonpeptide neuromedin B receptor antagonist PD 168368. J Pharmacol Exp Ther. 1999 Sep;290(3):1202-11. DMFNQEA RU https://pubmed.ncbi.nlm.nih.gov/10454496 DM7AY6K DI DM7AY6K DM7AY6K DN PD 176252 DM7AY6K MI TTHYDUM DM7AY6K MN Bombesin receptor (BS) DM7AY6K MT DTT DM7AY6K MA Antagonist DM7AY6K RN Characterization of putative GRP- and NMB-receptor antagonist's interaction with human receptors. Peptides. 2009 Aug;30(8):1473-86. DM7AY6K RU https://pubmed.ncbi.nlm.nih.gov/19463875 DM7AY6K DI DM7AY6K DM7AY6K DN PD 176252 DM7AY6K MI TTC1MVT DM7AY6K MN Gastrin-releasing peptide receptor (GRPR) DM7AY6K MT DTT DM7AY6K MA Antagonist DM7AY6K RN PD 176252--the first high affinity non-peptide gastrin-releasing peptide (BB2) receptor antagonist. Bioorg Med Chem Lett. 1998 Sep 22;8(18):2589-94. DM7AY6K RU https://pubmed.ncbi.nlm.nih.gov/9873586 DMD2CG9 DI DMD2CG9 DMD2CG9 DN PD-0166326 DMD2CG9 MI TTGKNB4 DMD2CG9 MN Epidermal growth factor receptor (EGFR) DMD2CG9 MT DTT DMD2CG9 MA Inhibitor DMD2CG9 RN Biochemical and cellular effects of c-Src kinase-selective pyrido[2, 3-d]pyrimidine tyrosine kinase inhibitors. Biochem Pharmacol. 2000 Oct 1;60(7):885-98. DMD2CG9 RU https://pubmed.ncbi.nlm.nih.gov/10974196 DMD2CG9 DI DMD2CG9 DMD2CG9 DN PD-0166326 DMD2CG9 MI TTRLW2X DMD2CG9 MN Fibroblast growth factor receptor 1 (FGFR1) DMD2CG9 MT DTT DMD2CG9 MA Inhibitor DMD2CG9 RN Biochemical and cellular effects of c-Src kinase-selective pyrido[2, 3-d]pyrimidine tyrosine kinase inhibitors. Biochem Pharmacol. 2000 Oct 1;60(7):885-98. DMD2CG9 RU https://pubmed.ncbi.nlm.nih.gov/10974196 DMD2CG9 DI DMD2CG9 DMD2CG9 DN PD-0166326 DMD2CG9 MI TT860QF DMD2CG9 MN LCK tyrosine protein kinase (LCK) DMD2CG9 MT DTT DMD2CG9 MA Inhibitor DMD2CG9 RN Biochemical and cellular effects of c-Src kinase-selective pyrido[2, 3-d]pyrimidine tyrosine kinase inhibitors. Biochem Pharmacol. 2000 Oct 1;60(7):885-98. DMD2CG9 RU https://pubmed.ncbi.nlm.nih.gov/10974196 DMD2CG9 DI DMD2CG9 DMD2CG9 DN PD-0166326 DMD2CG9 MI TT8FYO9 DMD2CG9 MN Platelet-derived growth factor receptor alpha (PDGFRA) DMD2CG9 MT DTT DMD2CG9 MA Inhibitor DMD2CG9 RN Biochemical and cellular effects of c-Src kinase-selective pyrido[2, 3-d]pyrimidine tyrosine kinase inhibitors. Biochem Pharmacol. 2000 Oct 1;60(7):885-98. DMD2CG9 RU https://pubmed.ncbi.nlm.nih.gov/10974196 DMD2CG9 DI DMD2CG9 DMD2CG9 DN PD-0166326 DMD2CG9 MI TTI7421 DMD2CG9 MN Platelet-derived growth factor receptor beta (PDGFRB) DMD2CG9 MT DTT DMD2CG9 MA Inhibitor DMD2CG9 RN Biochemical and cellular effects of c-Src kinase-selective pyrido[2, 3-d]pyrimidine tyrosine kinase inhibitors. Biochem Pharmacol. 2000 Oct 1;60(7):885-98. DMD2CG9 RU https://pubmed.ncbi.nlm.nih.gov/10974196 DMD2CG9 DI DMD2CG9 DMD2CG9 DN PD-0166326 DMD2CG9 MI TT6PKBN DMD2CG9 MN Proto-oncogene c-Src (SRC) DMD2CG9 MT DTT DMD2CG9 MA Inhibitor DMD2CG9 RN Structure-activity relationships of 6-(2,6-dichlorophenyl)-8-methyl-2-(phenylamino)pyrido[2,3-d]pyrimidin-7-ones: toward selective Abl inhibitors. Bioorg Med Chem Lett. 2009 Dec 15;19(24):6872-6. DMD2CG9 RU https://pubmed.ncbi.nlm.nih.gov/19889540 DMD2CG9 DI DMD2CG9 DMD2CG9 DN PD-0166326 DMD2CG9 MI TTQBR95 DMD2CG9 MN Stress-activated protein kinase 2a (p38 alpha) DMD2CG9 MT DTT DMD2CG9 MA Inhibitor DMD2CG9 RN Structure-activity relationships of 6-(2,6-dichlorophenyl)-8-methyl-2-(phenylamino)pyrido[2,3-d]pyrimidin-7-ones: toward selective Abl inhibitors. Bioorg Med Chem Lett. 2009 Dec 15;19(24):6872-6. DMD2CG9 RU https://pubmed.ncbi.nlm.nih.gov/19889540 DMD2CG9 DI DMD2CG9 DMD2CG9 DN PD-0166326 DMD2CG9 MI TT3PJMV DMD2CG9 MN Tyrosine-protein kinase ABL1 (ABL) DMD2CG9 MT DTT DMD2CG9 MA Inhibitor DMD2CG9 RN Structure-activity relationships of 6-(2,6-dichlorophenyl)-8-methyl-2-(phenylamino)pyrido[2,3-d]pyrimidin-7-ones: toward selective Abl inhibitors. Bioorg Med Chem Lett. 2009 Dec 15;19(24):6872-6. DMD2CG9 RU https://pubmed.ncbi.nlm.nih.gov/19889540 DMD2CG9 DI DMD2CG9 DMD2CG9 DN PD-0166326 DMD2CG9 MI TTX41N9 DMD2CG9 MN Tyrosine-protein kinase Kit (KIT) DMD2CG9 MT DTT DMD2CG9 MA Inhibitor DMD2CG9 RN Structure-activity relationships of 6-(2,6-dichlorophenyl)-8-methyl-2-(phenylamino)pyrido[2,3-d]pyrimidin-7-ones: toward selective Abl inhibitors. Bioorg Med Chem Lett. 2009 Dec 15;19(24):6872-6. DMD2CG9 RU https://pubmed.ncbi.nlm.nih.gov/19889540 DMSCQ9U DI DMSCQ9U DMSCQ9U DN PD-0173952 DMSCQ9U MI TTRLW2X DMSCQ9U MN Fibroblast growth factor receptor 1 (FGFR1) DMSCQ9U MT DTT DMSCQ9U MA Inhibitor DMSCQ9U RN Biochemical and cellular effects of c-Src kinase-selective pyrido[2, 3-d]pyrimidine tyrosine kinase inhibitors. Biochem Pharmacol. 2000 Oct 1;60(7):885-98. DMSCQ9U RU https://pubmed.ncbi.nlm.nih.gov/10974196 DMSCQ9U DI DMSCQ9U DMSCQ9U DN PD-0173952 DMSCQ9U MI TT860QF DMSCQ9U MN LCK tyrosine protein kinase (LCK) DMSCQ9U MT DTT DMSCQ9U MA Inhibitor DMSCQ9U RN Biochemical and cellular effects of c-Src kinase-selective pyrido[2, 3-d]pyrimidine tyrosine kinase inhibitors. Biochem Pharmacol. 2000 Oct 1;60(7):885-98. DMSCQ9U RU https://pubmed.ncbi.nlm.nih.gov/10974196 DMSCQ9U DI DMSCQ9U DMSCQ9U DN PD-0173952 DMSCQ9U MI TT8FYO9 DMSCQ9U MN Platelet-derived growth factor receptor alpha (PDGFRA) DMSCQ9U MT DTT DMSCQ9U MA Inhibitor DMSCQ9U RN Biochemical and cellular effects of c-Src kinase-selective pyrido[2, 3-d]pyrimidine tyrosine kinase inhibitors. Biochem Pharmacol. 2000 Oct 1;60(7):885-98. DMSCQ9U RU https://pubmed.ncbi.nlm.nih.gov/10974196 DMSCQ9U DI DMSCQ9U DMSCQ9U DN PD-0173952 DMSCQ9U MI TTI7421 DMSCQ9U MN Platelet-derived growth factor receptor beta (PDGFRB) DMSCQ9U MT DTT DMSCQ9U MA Inhibitor DMSCQ9U RN Biochemical and cellular effects of c-Src kinase-selective pyrido[2, 3-d]pyrimidine tyrosine kinase inhibitors. Biochem Pharmacol. 2000 Oct 1;60(7):885-98. DMSCQ9U RU https://pubmed.ncbi.nlm.nih.gov/10974196 DMSCQ9U DI DMSCQ9U DMSCQ9U DN PD-0173952 DMSCQ9U MI TT6PKBN DMSCQ9U MN Proto-oncogene c-Src (SRC) DMSCQ9U MT DTT DMSCQ9U MA Inhibitor DMSCQ9U RN Biochemical and cellular effects of c-Src kinase-selective pyrido[2, 3-d]pyrimidine tyrosine kinase inhibitors. Biochem Pharmacol. 2000 Oct 1;60(7):885-98. DMSCQ9U RU https://pubmed.ncbi.nlm.nih.gov/10974196 DMOZEW9 DI DMOZEW9 DMOZEW9 DN PD-0173955 DMOZEW9 MI TTRLW2X DMOZEW9 MN Fibroblast growth factor receptor 1 (FGFR1) DMOZEW9 MT DTT DMOZEW9 MA Inhibitor DMOZEW9 RN Biochemical and cellular effects of c-Src kinase-selective pyrido[2, 3-d]pyrimidine tyrosine kinase inhibitors. Biochem Pharmacol. 2000 Oct 1;60(7):885-98. DMOZEW9 RU https://pubmed.ncbi.nlm.nih.gov/10974196 DMOZEW9 DI DMOZEW9 DMOZEW9 DN PD-0173955 DMOZEW9 MI TTS7G69 DMOZEW9 MN Fusion protein Bcr-Abl (Bcr-Abl) DMOZEW9 MT DTT DMOZEW9 MA Inhibitor DMOZEW9 RN Structural insights into the ATP binding pocket of the anaplastic lymphoma kinase by site-directed mutagenesis, inhibitor binding analysis, and hom... J Med Chem. 2006 Sep 21;49(19):5759-68. DMOZEW9 RU https://pubmed.ncbi.nlm.nih.gov/16970400 DMOZEW9 DI DMOZEW9 DMOZEW9 DN PD-0173955 DMOZEW9 MI TT860QF DMOZEW9 MN LCK tyrosine protein kinase (LCK) DMOZEW9 MT DTT DMOZEW9 MA Inhibitor DMOZEW9 RN Biochemical and cellular effects of c-Src kinase-selective pyrido[2, 3-d]pyrimidine tyrosine kinase inhibitors. Biochem Pharmacol. 2000 Oct 1;60(7):885-98. DMOZEW9 RU https://pubmed.ncbi.nlm.nih.gov/10974196 DMOZEW9 DI DMOZEW9 DMOZEW9 DN PD-0173955 DMOZEW9 MI TT8FYO9 DMOZEW9 MN Platelet-derived growth factor receptor alpha (PDGFRA) DMOZEW9 MT DTT DMOZEW9 MA Inhibitor DMOZEW9 RN Biochemical and cellular effects of c-Src kinase-selective pyrido[2, 3-d]pyrimidine tyrosine kinase inhibitors. Biochem Pharmacol. 2000 Oct 1;60(7):885-98. DMOZEW9 RU https://pubmed.ncbi.nlm.nih.gov/10974196 DMOZEW9 DI DMOZEW9 DMOZEW9 DN PD-0173955 DMOZEW9 MI TTI7421 DMOZEW9 MN Platelet-derived growth factor receptor beta (PDGFRB) DMOZEW9 MT DTT DMOZEW9 MA Inhibitor DMOZEW9 RN Biochemical and cellular effects of c-Src kinase-selective pyrido[2, 3-d]pyrimidine tyrosine kinase inhibitors. Biochem Pharmacol. 2000 Oct 1;60(7):885-98. DMOZEW9 RU https://pubmed.ncbi.nlm.nih.gov/10974196 DMOZEW9 DI DMOZEW9 DMOZEW9 DN PD-0173955 DMOZEW9 MI TT6PKBN DMOZEW9 MN Proto-oncogene c-Src (SRC) DMOZEW9 MT DTT DMOZEW9 MA Inhibitor DMOZEW9 RN Biochemical and cellular effects of c-Src kinase-selective pyrido[2, 3-d]pyrimidine tyrosine kinase inhibitors. Biochem Pharmacol. 2000 Oct 1;60(7):885-98. DMOZEW9 RU https://pubmed.ncbi.nlm.nih.gov/10974196 DM8RW92 DI DM8RW92 DM8RW92 DN PD-0173956 DM8RW92 MI TTGKNB4 DM8RW92 MN Epidermal growth factor receptor (EGFR) DM8RW92 MT DTT DM8RW92 MA Inhibitor DM8RW92 RN Biochemical and cellular effects of c-Src kinase-selective pyrido[2, 3-d]pyrimidine tyrosine kinase inhibitors. Biochem Pharmacol. 2000 Oct 1;60(7):885-98. DM8RW92 RU https://pubmed.ncbi.nlm.nih.gov/10974196 DM8RW92 DI DM8RW92 DM8RW92 DN PD-0173956 DM8RW92 MI TTRLW2X DM8RW92 MN Fibroblast growth factor receptor 1 (FGFR1) DM8RW92 MT DTT DM8RW92 MA Inhibitor DM8RW92 RN Biochemical and cellular effects of c-Src kinase-selective pyrido[2, 3-d]pyrimidine tyrosine kinase inhibitors. Biochem Pharmacol. 2000 Oct 1;60(7):885-98. DM8RW92 RU https://pubmed.ncbi.nlm.nih.gov/10974196 DM8RW92 DI DM8RW92 DM8RW92 DN PD-0173956 DM8RW92 MI TT860QF DM8RW92 MN LCK tyrosine protein kinase (LCK) DM8RW92 MT DTT DM8RW92 MA Inhibitor DM8RW92 RN Biochemical and cellular effects of c-Src kinase-selective pyrido[2, 3-d]pyrimidine tyrosine kinase inhibitors. Biochem Pharmacol. 2000 Oct 1;60(7):885-98. DM8RW92 RU https://pubmed.ncbi.nlm.nih.gov/10974196 DM8RW92 DI DM8RW92 DM8RW92 DN PD-0173956 DM8RW92 MI TT8FYO9 DM8RW92 MN Platelet-derived growth factor receptor alpha (PDGFRA) DM8RW92 MT DTT DM8RW92 MA Inhibitor DM8RW92 RN Biochemical and cellular effects of c-Src kinase-selective pyrido[2, 3-d]pyrimidine tyrosine kinase inhibitors. Biochem Pharmacol. 2000 Oct 1;60(7):885-98. DM8RW92 RU https://pubmed.ncbi.nlm.nih.gov/10974196 DM8RW92 DI DM8RW92 DM8RW92 DN PD-0173956 DM8RW92 MI TTI7421 DM8RW92 MN Platelet-derived growth factor receptor beta (PDGFRB) DM8RW92 MT DTT DM8RW92 MA Inhibitor DM8RW92 RN Biochemical and cellular effects of c-Src kinase-selective pyrido[2, 3-d]pyrimidine tyrosine kinase inhibitors. Biochem Pharmacol. 2000 Oct 1;60(7):885-98. DM8RW92 RU https://pubmed.ncbi.nlm.nih.gov/10974196 DM8RW92 DI DM8RW92 DM8RW92 DN PD-0173956 DM8RW92 MI TT6PKBN DM8RW92 MN Proto-oncogene c-Src (SRC) DM8RW92 MT DTT DM8RW92 MA Inhibitor DM8RW92 RN Structure-activity relationships of 6-(2,6-dichlorophenyl)-8-methyl-2-(phenylamino)pyrido[2,3-d]pyrimidin-7-ones: toward selective Abl inhibitors. Bioorg Med Chem Lett. 2009 Dec 15;19(24):6872-6. DM8RW92 RU https://pubmed.ncbi.nlm.nih.gov/19889540 DM8RW92 DI DM8RW92 DM8RW92 DN PD-0173956 DM8RW92 MI TTQBR95 DM8RW92 MN Stress-activated protein kinase 2a (p38 alpha) DM8RW92 MT DTT DM8RW92 MA Inhibitor DM8RW92 RN Structure-activity relationships of 6-(2,6-dichlorophenyl)-8-methyl-2-(phenylamino)pyrido[2,3-d]pyrimidin-7-ones: toward selective Abl inhibitors. Bioorg Med Chem Lett. 2009 Dec 15;19(24):6872-6. DM8RW92 RU https://pubmed.ncbi.nlm.nih.gov/19889540 DM8RW92 DI DM8RW92 DM8RW92 DN PD-0173956 DM8RW92 MI TT3PJMV DM8RW92 MN Tyrosine-protein kinase ABL1 (ABL) DM8RW92 MT DTT DM8RW92 MA Inhibitor DM8RW92 RN Structure-activity relationships of 6-(2,6-dichlorophenyl)-8-methyl-2-(phenylamino)pyrido[2,3-d]pyrimidin-7-ones: toward selective Abl inhibitors. Bioorg Med Chem Lett. 2009 Dec 15;19(24):6872-6. DM8RW92 RU https://pubmed.ncbi.nlm.nih.gov/19889540 DM8RW92 DI DM8RW92 DM8RW92 DN PD-0173956 DM8RW92 MI TTX41N9 DM8RW92 MN Tyrosine-protein kinase Kit (KIT) DM8RW92 MT DTT DM8RW92 MA Inhibitor DM8RW92 RN Structure-activity relationships of 6-(2,6-dichlorophenyl)-8-methyl-2-(phenylamino)pyrido[2,3-d]pyrimidin-7-ones: toward selective Abl inhibitors. Bioorg Med Chem Lett. 2009 Dec 15;19(24):6872-6. DM8RW92 RU https://pubmed.ncbi.nlm.nih.gov/19889540 DMZQ8YV DI DMZQ8YV DMZQ8YV DN PD-0173958 DMZQ8YV MI TTRLW2X DMZQ8YV MN Fibroblast growth factor receptor 1 (FGFR1) DMZQ8YV MT DTT DMZQ8YV MA Inhibitor DMZQ8YV RN Biochemical and cellular effects of c-Src kinase-selective pyrido[2, 3-d]pyrimidine tyrosine kinase inhibitors. Biochem Pharmacol. 2000 Oct 1;60(7):885-98. DMZQ8YV RU https://pubmed.ncbi.nlm.nih.gov/10974196 DMZQ8YV DI DMZQ8YV DMZQ8YV DN PD-0173958 DMZQ8YV MI TT860QF DMZQ8YV MN LCK tyrosine protein kinase (LCK) DMZQ8YV MT DTT DMZQ8YV MA Inhibitor DMZQ8YV RN Biochemical and cellular effects of c-Src kinase-selective pyrido[2, 3-d]pyrimidine tyrosine kinase inhibitors. Biochem Pharmacol. 2000 Oct 1;60(7):885-98. DMZQ8YV RU https://pubmed.ncbi.nlm.nih.gov/10974196 DMZQ8YV DI DMZQ8YV DMZQ8YV DN PD-0173958 DMZQ8YV MI TT8FYO9 DMZQ8YV MN Platelet-derived growth factor receptor alpha (PDGFRA) DMZQ8YV MT DTT DMZQ8YV MA Inhibitor DMZQ8YV RN Biochemical and cellular effects of c-Src kinase-selective pyrido[2, 3-d]pyrimidine tyrosine kinase inhibitors. Biochem Pharmacol. 2000 Oct 1;60(7):885-98. DMZQ8YV RU https://pubmed.ncbi.nlm.nih.gov/10974196 DMZQ8YV DI DMZQ8YV DMZQ8YV DN PD-0173958 DMZQ8YV MI TTI7421 DMZQ8YV MN Platelet-derived growth factor receptor beta (PDGFRB) DMZQ8YV MT DTT DMZQ8YV MA Inhibitor DMZQ8YV RN Biochemical and cellular effects of c-Src kinase-selective pyrido[2, 3-d]pyrimidine tyrosine kinase inhibitors. Biochem Pharmacol. 2000 Oct 1;60(7):885-98. DMZQ8YV RU https://pubmed.ncbi.nlm.nih.gov/10974196 DMZQ8YV DI DMZQ8YV DMZQ8YV DN PD-0173958 DMZQ8YV MI TT6PKBN DMZQ8YV MN Proto-oncogene c-Src (SRC) DMZQ8YV MT DTT DMZQ8YV MA Inhibitor DMZQ8YV RN Biochemical and cellular effects of c-Src kinase-selective pyrido[2, 3-d]pyrimidine tyrosine kinase inhibitors. Biochem Pharmacol. 2000 Oct 1;60(7):885-98. DMZQ8YV RU https://pubmed.ncbi.nlm.nih.gov/10974196 DMKO8LE DI DMKO8LE DMKO8LE DN PD-0179483 DMKO8LE MI TTRLW2X DMKO8LE MN Fibroblast growth factor receptor 1 (FGFR1) DMKO8LE MT DTT DMKO8LE MA Inhibitor DMKO8LE RN Biochemical and cellular effects of c-Src kinase-selective pyrido[2, 3-d]pyrimidine tyrosine kinase inhibitors. Biochem Pharmacol. 2000 Oct 1;60(7):885-98. DMKO8LE RU https://pubmed.ncbi.nlm.nih.gov/10974196 DMKO8LE DI DMKO8LE DMKO8LE DN PD-0179483 DMKO8LE MI TT860QF DMKO8LE MN LCK tyrosine protein kinase (LCK) DMKO8LE MT DTT DMKO8LE MA Inhibitor DMKO8LE RN Biochemical and cellular effects of c-Src kinase-selective pyrido[2, 3-d]pyrimidine tyrosine kinase inhibitors. Biochem Pharmacol. 2000 Oct 1;60(7):885-98. DMKO8LE RU https://pubmed.ncbi.nlm.nih.gov/10974196 DMKO8LE DI DMKO8LE DMKO8LE DN PD-0179483 DMKO8LE MI TT8FYO9 DMKO8LE MN Platelet-derived growth factor receptor alpha (PDGFRA) DMKO8LE MT DTT DMKO8LE MA Inhibitor DMKO8LE RN Biochemical and cellular effects of c-Src kinase-selective pyrido[2, 3-d]pyrimidine tyrosine kinase inhibitors. Biochem Pharmacol. 2000 Oct 1;60(7):885-98. DMKO8LE RU https://pubmed.ncbi.nlm.nih.gov/10974196 DMKO8LE DI DMKO8LE DMKO8LE DN PD-0179483 DMKO8LE MI TTI7421 DMKO8LE MN Platelet-derived growth factor receptor beta (PDGFRB) DMKO8LE MT DTT DMKO8LE MA Inhibitor DMKO8LE RN Biochemical and cellular effects of c-Src kinase-selective pyrido[2, 3-d]pyrimidine tyrosine kinase inhibitors. Biochem Pharmacol. 2000 Oct 1;60(7):885-98. DMKO8LE RU https://pubmed.ncbi.nlm.nih.gov/10974196 DMKO8LE DI DMKO8LE DMKO8LE DN PD-0179483 DMKO8LE MI TT6PKBN DMKO8LE MN Proto-oncogene c-Src (SRC) DMKO8LE MT DTT DMKO8LE MA Inhibitor DMKO8LE RN Biochemical and cellular effects of c-Src kinase-selective pyrido[2, 3-d]pyrimidine tyrosine kinase inhibitors. Biochem Pharmacol. 2000 Oct 1;60(7):885-98. DMKO8LE RU https://pubmed.ncbi.nlm.nih.gov/10974196 DM8QMJ1 DI DM8QMJ1 DM8QMJ1 DN PD-068235 DM8QMJ1 MI TTT2SVW DM8QMJ1 MN PPAR-gamma messenger RNA (PPARG mRNA) DM8QMJ1 MT DTT DM8QMJ1 MA Inhibitor DM8QMJ1 RN Tryptophan-containing dipeptide derivatives as potent PPARgamma antagonists: design, synthesis, biological evaluation, and molecular modeling. Eur J Med Chem. 2008 Dec;43(12):2699-716. DM8QMJ1 RU https://pubmed.ncbi.nlm.nih.gov/18329752 DMQ4LRZ DI DMQ4LRZ DMQ4LRZ DN PD-115199 DMQ4LRZ MI TTK25J1 DMQ4LRZ MN Adenosine A1 receptor (ADORA1) DMQ4LRZ MT DTT DMQ4LRZ MA Inhibitor DMQ4LRZ RN (E)-1,3-dialkyl-7-methyl-8-(3,4,5-trimethoxystyryl)xanthines: potent and selective adenosine A2 antagonists. J Med Chem. 1992 Jun 12;35(12):2342-5. DMQ4LRZ RU https://pubmed.ncbi.nlm.nih.gov/1613758 DMQ4LRZ DI DMQ4LRZ DMQ4LRZ DN PD-115199 DMQ4LRZ MI TTM2AOE DMQ4LRZ MN Adenosine A2a receptor (ADORA2A) DMQ4LRZ MT DTT DMQ4LRZ MA Inhibitor DMQ4LRZ RN (E)-1,3-dialkyl-7-methyl-8-(3,4,5-trimethoxystyryl)xanthines: potent and selective adenosine A2 antagonists. J Med Chem. 1992 Jun 12;35(12):2342-5. DMQ4LRZ RU https://pubmed.ncbi.nlm.nih.gov/1613758 DMQ4LRZ DI DMQ4LRZ DMQ4LRZ DN PD-115199 DMQ4LRZ MI TTNE7KG DMQ4LRZ MN Adenosine A2b receptor (ADORA2B) DMQ4LRZ MT DTT DMQ4LRZ MA Inhibitor DMQ4LRZ RN (E)-1,3-dialkyl-7-methyl-8-(3,4,5-trimethoxystyryl)xanthines: potent and selective adenosine A2 antagonists. J Med Chem. 1992 Jun 12;35(12):2342-5. DMQ4LRZ RU https://pubmed.ncbi.nlm.nih.gov/1613758 DM3KAY5 DI DM3KAY5 DM3KAY5 DN PD-117558 DM3KAY5 MI TTN6J5F DM3KAY5 MN Bacterial DNA gyrase (Bact gyrase) DM3KAY5 MT DTT DM3KAY5 MA Modulator DM3KAY5 RN 1-Substituted 7-[3-[(ethylamino)methyl]-1-pyrrolidinyl]-6,8- difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acids.New quantitative structure-activity relationships at N1 for the quinolone antibacterials.J Med Chem.1988 May;31(5):991-1001. DM3KAY5 RU https://www.ncbi.nlm.nih.gov/pubmed/2834557 DM0E4OW DI DM0E4OW DM0E4OW DN PD-118057 DM0E4OW MI TTQ6VDM DM0E4OW MN Voltage-gated potassium channel Kv11.1 (KCNH2) DM0E4OW MT DTT DM0E4OW MA Activator DM0E4OW RN Novel potent human ether-a-go-go-related gene (hERG) potassium channel enhancers and their in vitro antiarrhythmic activity. Mol Pharmacol. 2005 Sep;68(3):876-84. DM0E4OW RU https://pubmed.ncbi.nlm.nih.gov/15976038 DM4OQZX DI DM4OQZX DM4OQZX DN PD123177 DM4OQZX MI TTQVOEI DM4OQZX MN Angiotensin II receptor type-2 (AGTR2) DM4OQZX MT DTT DM4OQZX MA Antagonist DM4OQZX RN Two distinct angiotensin II receptor binding sites in rat adrenal revealed by new selective nonpeptide ligands. Mol Pharmacol. 1990 Mar;37(3):347-51. DM4OQZX RU https://pubmed.ncbi.nlm.nih.gov/2314387 DMV1F7U DI DMV1F7U DMV1F7U DN PD-128763 DMV1F7U MI TTVDSZ0 DMV1F7U MN Poly [ADP-ribose] polymerase 1 (PARP1) DMV1F7U MT DTT DMV1F7U MA Inhibitor DMV1F7U RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMV1F7U RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMYEFAV DI DMYEFAV DMYEFAV DN PD-135111 DMYEFAV MI TTEX248 DMYEFAV MN Dopamine D2 receptor (D2R) DMYEFAV MT DTT DMYEFAV MA Inhibitor DMYEFAV RN Synthesis and pharmacological evaluation of the enantiomers of the dopamine autoreceptor agonist PD 135385, Bioorg. Med. Chem. Lett. 3(4):639-644 (1993). DMYEFAV RU http://www.sciencedirect.com/science/article/pii/S0960894X01812452 DMUTEWI DI DMUTEWI DMUTEWI DN PD-135118 DMUTEWI MI TTCG0AL DMUTEWI MN Cholecystokinin receptor type A (CCKAR) DMUTEWI MT DTT DMUTEWI MA Inhibitor DMUTEWI RN Selective ligands for cholecystokinin receptor subtypes CCK-A and CCK-B within a single structural class, Bioorg. Med. Chem. Lett. 3(5):881-884 (1993). DMUTEWI RU http://www.sciencedirect.com/science/article/pii/S0960894X0080685X DMUTEWI DI DMUTEWI DMUTEWI DN PD-135118 DMUTEWI MI TTVFO0U DMUTEWI MN Gastrin/cholecystokinin type B receptor (CCKBR) DMUTEWI MT DTT DMUTEWI MA Inhibitor DMUTEWI RN Selective ligands for cholecystokinin receptor subtypes CCK-A and CCK-B within a single structural class, Bioorg. Med. Chem. Lett. 3(5):881-884 (1993). DMUTEWI RU http://www.sciencedirect.com/science/article/pii/S0960894X0080685X DMZ4LDC DI DMZ4LDC DMZ4LDC DN PD-135146 DMZ4LDC MI TTEX248 DMZ4LDC MN Dopamine D2 receptor (D2R) DMZ4LDC MT DTT DMZ4LDC MA Inhibitor DMZ4LDC RN Synthesis and pharmacological evaluation of the enantiomers of the dopamine autoreceptor agonist PD 135385, Bioorg. Med. Chem. Lett. 3(4):639-644 (1993). DMZ4LDC RU http://www.sciencedirect.com/science/article/pii/S0960894X01812452 DMA7YJV DI DMA7YJV DMA7YJV DN PD-135158 DMA7YJV MI TTCG0AL DMA7YJV MN Cholecystokinin receptor type A (CCKAR) DMA7YJV MT DTT DMA7YJV MA Antagonist DMA7YJV RN Development of a class of selective cholecystokinin type B receptor antagonists having potent anxiolytic activity. Proc Natl Acad Sci U S A. 1990 Sep;87(17):6728-32. DMA7YJV RU https://pubmed.ncbi.nlm.nih.gov/1975695 DMA7YJV DI DMA7YJV DMA7YJV DN PD-135158 DMA7YJV MI TTVFO0U DMA7YJV MN Gastrin/cholecystokinin type B receptor (CCKBR) DMA7YJV MT DTT DMA7YJV MA Antagonist DMA7YJV RN Pharmacological characterization of a Chinese hamster ovary cell line transfected with the human CCK-B receptor gene. Neuropeptides. 1996 Aug;30(4):359-63. DMA7YJV RU https://pubmed.ncbi.nlm.nih.gov/8914862 DMSHBLF DI DMSHBLF DMSHBLF DN PD-135188 DMSHBLF MI TTEX248 DMSHBLF MN Dopamine D2 receptor (D2R) DMSHBLF MT DTT DMSHBLF MA Inhibitor DMSHBLF RN Synthesis and pharmacological evaluation of the enantiomers of the dopamine autoreceptor agonist PD 135385, Bioorg. Med. Chem. Lett. 3(4):639-644 (1993). DMSHBLF RU http://www.sciencedirect.com/science/article/pii/S0960894X01812452 DM0LTNJ DI DM0LTNJ DM0LTNJ DN PD-135222 DM0LTNJ MI TTEX248 DM0LTNJ MN Dopamine D2 receptor (D2R) DM0LTNJ MT DTT DM0LTNJ MA Inhibitor DM0LTNJ RN Synthesis and pharmacological evaluation of the enantiomers of the dopamine autoreceptor agonist PD 135385, Bioorg. Med. Chem. Lett. 3(4):639-644 (1993). DM0LTNJ RU http://www.sciencedirect.com/science/article/pii/S0960894X01812452 DMX294V DI DMX294V DMX294V DN PD-135385 DMX294V MI TTEX248 DMX294V MN Dopamine D2 receptor (D2R) DMX294V MT DTT DMX294V MA Inhibitor DMX294V RN Synthesis and pharmacological evaluation of the enantiomers of the dopamine autoreceptor agonist PD 135385, Bioorg. Med. Chem. Lett. 3(4):639-644 (1993). DMX294V RU http://www.sciencedirect.com/science/article/pii/S0960894X01812452 DM56PBI DI DM56PBI DM56PBI DN PD-135478 DM56PBI MI TTEX248 DM56PBI MN Dopamine D2 receptor (D2R) DM56PBI MT DTT DM56PBI MA Inhibitor DM56PBI RN Synthesis and pharmacological evaluation of the enantiomers of the dopamine autoreceptor agonist PD 135385, Bioorg. Med. Chem. Lett. 3(4):639-644 (1993). DM56PBI RU http://www.sciencedirect.com/science/article/pii/S0960894X01812452 DMI4MPZ DI DMI4MPZ DMI4MPZ DN PD-135540 DMI4MPZ MI TTEX248 DMI4MPZ MN Dopamine D2 receptor (D2R) DMI4MPZ MT DTT DMI4MPZ MA Inhibitor DMI4MPZ RN Synthesis and pharmacological evaluation of the enantiomers of the dopamine autoreceptor agonist PD 135385, Bioorg. Med. Chem. Lett. 3(4):639-644 (1993). DMI4MPZ RU http://www.sciencedirect.com/science/article/pii/S0960894X01812452 DM8N3RB DI DM8N3RB DM8N3RB DN PD-136621 DM8N3RB MI TTCG0AL DM8N3RB MN Cholecystokinin receptor type A (CCKAR) DM8N3RB MT DTT DM8N3RB MA Inhibitor DM8N3RB RN Selective ligands for cholecystokinin receptor subtypes CCK-A and CCK-B within a single structural class, Bioorg. Med. Chem. Lett. 3(5):881-884 (1993). DM8N3RB RU http://www.sciencedirect.com/science/article/pii/S0960894X0080685X DM8N3RB DI DM8N3RB DM8N3RB DN PD-136621 DM8N3RB MI TTVFO0U DM8N3RB MN Gastrin/cholecystokinin type B receptor (CCKBR) DM8N3RB MT DTT DM8N3RB MA Inhibitor DM8N3RB RN Selective ligands for cholecystokinin receptor subtypes CCK-A and CCK-B within a single structural class, Bioorg. Med. Chem. Lett. 3(5):881-884 (1993). DM8N3RB RU http://www.sciencedirect.com/science/article/pii/S0960894X0080685X DMJWK0T DI DMJWK0T DMJWK0T DN PD-137337 DMJWK0T MI TTCG0AL DMJWK0T MN Cholecystokinin receptor type A (CCKAR) DMJWK0T MT DTT DMJWK0T MA Inhibitor DMJWK0T RN Selective ligands for cholecystokinin receptor subtypes CCK-A and CCK-B within a single structural class, Bioorg. Med. Chem. Lett. 3(5):881-884 (1993). DMJWK0T RU http://www.sciencedirect.com/science/article/pii/S0960894X0080685X DMJWK0T DI DMJWK0T DMJWK0T DN PD-137337 DMJWK0T MI TTVFO0U DMJWK0T MN Gastrin/cholecystokinin type B receptor (CCKBR) DMJWK0T MT DTT DMJWK0T MA Inhibitor DMJWK0T RN Selective ligands for cholecystokinin receptor subtypes CCK-A and CCK-B within a single structural class, Bioorg. Med. Chem. Lett. 3(5):881-884 (1993). DMJWK0T RU http://www.sciencedirect.com/science/article/pii/S0960894X0080685X DMH2OV9 DI DMH2OV9 DMH2OV9 DN PD-137342 DMH2OV9 MI TTCG0AL DMH2OV9 MN Cholecystokinin receptor type A (CCKAR) DMH2OV9 MT DTT DMH2OV9 MA Inhibitor DMH2OV9 RN Selective ligands for cholecystokinin receptor subtypes CCK-A and CCK-B within a single structural class, Bioorg. Med. Chem. Lett. 3(5):881-884 (1993). DMH2OV9 RU http://www.sciencedirect.com/science/article/pii/S0960894X0080685X DMH2OV9 DI DMH2OV9 DMH2OV9 DN PD-137342 DMH2OV9 MI TTVFO0U DMH2OV9 MN Gastrin/cholecystokinin type B receptor (CCKBR) DMH2OV9 MT DTT DMH2OV9 MA Inhibitor DMH2OV9 RN Selective ligands for cholecystokinin receptor subtypes CCK-A and CCK-B within a single structural class, Bioorg. Med. Chem. Lett. 3(5):881-884 (1993). DMH2OV9 RU http://www.sciencedirect.com/science/article/pii/S0960894X0080685X DM9ZK6L DI DM9ZK6L DM9ZK6L DN PD-137789 DM9ZK6L MI TTEX248 DM9ZK6L MN Dopamine D2 receptor (D2R) DM9ZK6L MT DTT DM9ZK6L MA Inhibitor DM9ZK6L RN Synthesis and pharmacological evaluation of the enantiomers of the dopamine autoreceptor agonist PD 135385, Bioorg. Med. Chem. Lett. 3(4):639-644 (1993). DM9ZK6L RU http://www.sciencedirect.com/science/article/pii/S0960894X01812452 DMYMFSE DI DMYMFSE DMYMFSE DN PD-137821 DMYMFSE MI TTEX248 DMYMFSE MN Dopamine D2 receptor (D2R) DMYMFSE MT DTT DMYMFSE MA Inhibitor DMYMFSE RN Synthesis and pharmacological evaluation of the enantiomers of the dopamine autoreceptor agonist PD 135385, Bioorg. Med. Chem. Lett. 3(4):639-644 (1993). DMYMFSE RU http://www.sciencedirect.com/science/article/pii/S0960894X01812452 DMLVRU7 DI DMLVRU7 DMLVRU7 DN PD-138915 DMLVRU7 MI TTCG0AL DMLVRU7 MN Cholecystokinin receptor type A (CCKAR) DMLVRU7 MT DTT DMLVRU7 MA Inhibitor DMLVRU7 RN Selective ligands for cholecystokinin receptor subtypes CCK-A and CCK-B within a single structural class, Bioorg. Med. Chem. Lett. 3(5):881-884 (1993). DMLVRU7 RU http://www.sciencedirect.com/science/article/pii/S0960894X0080685X DMLVRU7 DI DMLVRU7 DMLVRU7 DN PD-138915 DMLVRU7 MI TTVFO0U DMLVRU7 MN Gastrin/cholecystokinin type B receptor (CCKBR) DMLVRU7 MT DTT DMLVRU7 MA Inhibitor DMLVRU7 RN Selective ligands for cholecystokinin receptor subtypes CCK-A and CCK-B within a single structural class, Bioorg. Med. Chem. Lett. 3(5):881-884 (1993). DMLVRU7 RU http://www.sciencedirect.com/science/article/pii/S0960894X0080685X DMIAFN5 DI DMIAFN5 DMIAFN5 DN PD-138916 DMIAFN5 MI TTCG0AL DMIAFN5 MN Cholecystokinin receptor type A (CCKAR) DMIAFN5 MT DTT DMIAFN5 MA Inhibitor DMIAFN5 RN Selective ligands for cholecystokinin receptor subtypes CCK-A and CCK-B within a single structural class, Bioorg. Med. Chem. Lett. 3(5):881-884 (1993). DMIAFN5 RU http://www.sciencedirect.com/science/article/pii/S0960894X0080685X DMIAFN5 DI DMIAFN5 DMIAFN5 DN PD-138916 DMIAFN5 MI TTVFO0U DMIAFN5 MN Gastrin/cholecystokinin type B receptor (CCKBR) DMIAFN5 MT DTT DMIAFN5 MA Inhibitor DMIAFN5 RN Selective ligands for cholecystokinin receptor subtypes CCK-A and CCK-B within a single structural class, Bioorg. Med. Chem. Lett. 3(5):881-884 (1993). DMIAFN5 RU http://www.sciencedirect.com/science/article/pii/S0960894X0080685X DMUG2L9 DI DMUG2L9 DMUG2L9 DN PD-138917 DMUG2L9 MI TTVFO0U DMUG2L9 MN Gastrin/cholecystokinin type B receptor (CCKBR) DMUG2L9 MT DTT DMUG2L9 MA Inhibitor DMUG2L9 RN Selective ligands for cholecystokinin receptor subtypes CCK-A and CCK-B within a single structural class, Bioorg. Med. Chem. Lett. 3(5):881-884 (1993). DMUG2L9 RU http://www.sciencedirect.com/science/article/pii/S0960894X0080685X DMF86P3 DI DMF86P3 DMF86P3 DN PD-140547 DMF86P3 MI TTCG0AL DMF86P3 MN Cholecystokinin receptor type A (CCKAR) DMF86P3 MT DTT DMF86P3 MA Inhibitor DMF86P3 RN Selective ligands for cholecystokinin receptor subtypes CCK-A and CCK-B within a single structural class, Bioorg. Med. Chem. Lett. 3(5):881-884 (1993). DMF86P3 RU http://www.sciencedirect.com/science/article/pii/S0960894X0080685X DMF86P3 DI DMF86P3 DMF86P3 DN PD-140547 DMF86P3 MI TTVFO0U DMF86P3 MN Gastrin/cholecystokinin type B receptor (CCKBR) DMF86P3 MT DTT DMF86P3 MA Inhibitor DMF86P3 RN Selective ligands for cholecystokinin receptor subtypes CCK-A and CCK-B within a single structural class, Bioorg. Med. Chem. Lett. 3(5):881-884 (1993). DMF86P3 RU http://www.sciencedirect.com/science/article/pii/S0960894X0080685X DMNO2EP DI DMNO2EP DMNO2EP DN PD-140548 DMNO2EP MI TTCG0AL DMNO2EP MN Cholecystokinin receptor type A (CCKAR) DMNO2EP MT DTT DMNO2EP MA Inhibitor DMNO2EP RN Selective ligands for cholecystokinin receptor subtypes CCK-A and CCK-B within a single structural class, Bioorg. Med. Chem. Lett. 3(5):881-884 (1993). DMNO2EP RU http://www.sciencedirect.com/science/article/pii/S0960894X0080685X DMNO2EP DI DMNO2EP DMNO2EP DN PD-140548 DMNO2EP MI TTVFO0U DMNO2EP MN Gastrin/cholecystokinin type B receptor (CCKBR) DMNO2EP MT DTT DMNO2EP MA Inhibitor DMNO2EP RN Selective ligands for cholecystokinin receptor subtypes CCK-A and CCK-B within a single structural class, Bioorg. Med. Chem. Lett. 3(5):881-884 (1993). DMNO2EP RU http://www.sciencedirect.com/science/article/pii/S0960894X0080685X DMWTOJN DI DMWTOJN DMWTOJN DN PD-140723 DMWTOJN MI TTCG0AL DMWTOJN MN Cholecystokinin receptor type A (CCKAR) DMWTOJN MT DTT DMWTOJN MA Inhibitor DMWTOJN RN Selective ligands for cholecystokinin receptor subtypes CCK-A and CCK-B within a single structural class, Bioorg. Med. Chem. Lett. 3(5):881-884 (1993). DMWTOJN RU http://www.sciencedirect.com/science/article/pii/S0960894X0080685X DMWTOJN DI DMWTOJN DMWTOJN DN PD-140723 DMWTOJN MI TTVFO0U DMWTOJN MN Gastrin/cholecystokinin type B receptor (CCKBR) DMWTOJN MT DTT DMWTOJN MA Inhibitor DMWTOJN RN Selective ligands for cholecystokinin receptor subtypes CCK-A and CCK-B within a single structural class, Bioorg. Med. Chem. Lett. 3(5):881-884 (1993). DMWTOJN RU http://www.sciencedirect.com/science/article/pii/S0960894X0080685X DMJKH28 DI DMJKH28 DMJKH28 DN PD-144418 DMJKH28 MI TTTPE1L DMJKH28 MN HUMAN opioid receptor sigma 1 (OPRS1) DMJKH28 MT DTT DMJKH28 MA Antagonist DMJKH28 RN A SARS-CoV-2 protein interaction map reveals targets for drug repurposing DMJKH28 RU https://www.nature.com/articles/s41586-020-2286-9 DM03526 DI DM03526 DM03526 DN PD-144550 DM03526 MI TTFK1JQ DM03526 MN Voltage-gated calcium channel alpha-2/delta-1 (CACNA2D1) DM03526 MT DTT DM03526 MA Inhibitor DM03526 RN Enantioselective synthesis of PD144723: a potent stereospecific anticonvulsant, Bioorg. Med. Chem. Lett. 4(6):823-826 (1994). DM03526 RU http://www.sciencedirect.com/science/article/pii/S0960894X01808556 DM03526 DI DM03526 DM03526 DN PD-144550 DM03526 MI TTU8P3M DM03526 MN Voltage-gated calcium channel alpha-2/delta-2 (CACNA2D2) DM03526 MT DTT DM03526 MA Inhibitor DM03526 RN Enantioselective synthesis of PD144723: a potent stereospecific anticonvulsant, Bioorg. Med. Chem. Lett. 4(6):823-826 (1994). DM03526 RU http://www.sciencedirect.com/science/article/pii/S0960894X01808556 DM03526 DI DM03526 DM03526 DN PD-144550 DM03526 MI TTN7T29 DM03526 MN Voltage-gated calcium channel alpha-2/delta-3 (CACNA2D3) DM03526 MT DTT DM03526 MA Inhibitor DM03526 RN Enantioselective synthesis of PD144723: a potent stereospecific anticonvulsant, Bioorg. Med. Chem. Lett. 4(6):823-826 (1994). DM03526 RU http://www.sciencedirect.com/science/article/pii/S0960894X01808556 DMP65EI DI DMP65EI DMP65EI DN PD-149164 DMP65EI MI TTVFO0U DMP65EI MN Gastrin/cholecystokinin type B receptor (CCKBR) DMP65EI MT DTT DMP65EI MA Antagonist DMP65EI RN Cholecystokinin B antagonists. Synthesis and quantitative structure-activity relationships of a series of C-terminal analogues of CI-988. Bioorg Med Chem. 1996 Oct;4(10):1733-45. DMP65EI RU https://pubmed.ncbi.nlm.nih.gov/8931944 DMHD8UL DI DMHD8UL DMHD8UL DN PD-151307 DMHD8UL MI TT4FDG6 DMHD8UL MN Voltage-gated calcium channel alpha Cav2.2 (CACNA1B) DMHD8UL MT DTT DMHD8UL MA Inhibitor DMHD8UL RN Synthesis of a series of 4-benzyloxyaniline analogues as neuronal N-type calcium channel blockers with improved anticonvulsant and analgesic proper... J Med Chem. 1999 Oct 7;42(20):4239-49. DMHD8UL RU https://pubmed.ncbi.nlm.nih.gov/10514294 DMV0EDM DI DMV0EDM DMV0EDM DN PD-152255 DMV0EDM MI TT4C8EA DMV0EDM MN Dopamine D3 receptor (D3R) DMV0EDM MT DTT DMV0EDM MA Modulator DMV0EDM RN Pharmacological characterization of PD 152255, a novel dimeric benzimidazole dopamine D3 antagonist. Pharmacol Biochem Behav. 1998 Feb;59(2):487-93. DMV0EDM RU https://www.ncbi.nlm.nih.gov/pubmed/9476999 DMY5SX9 DI DMY5SX9 DMY5SX9 DN PD-156 DMY5SX9 MI TTHY57M DMY5SX9 MN Matrix metalloproteinase-13 (MMP-13) DMY5SX9 MT DTT DMY5SX9 MA Inhibitor DMY5SX9 RN Selective matrix metalloproteinase inhibition attenuates progression of left ventricular dysfunction and remodeling in dogs with chronic heart fail... Am J Physiol Heart Circ Physiol. 2006 Jun;290(6):H2522-7. DMY5SX9 RU https://pubmed.ncbi.nlm.nih.gov/16428338 DMHI8C9 DI DMHI8C9 DMHI8C9 DN PD-157672 DMHI8C9 MI TTBPGLU DMHI8C9 MN Neuromedin-K receptor (TACR3) DMHI8C9 MT DTT DMHI8C9 MA Inhibitor DMHI8C9 RN The rational development of small molecule tachykinin NK3 receptor selective antagonists - the utilisation of a dipeptide chemical library in drug design, Bioorg. Med. Chem. Lett. 4(14):1679-1684 (1994). DMHI8C9 RU http://www.sciencedirect.com/science/article/pii/S0960894X00803601 DMQXYE9 DI DMQXYE9 DMQXYE9 DN PD-158780 DMQXYE9 MI TTGKNB4 DMQXYE9 MN Epidermal growth factor receptor (EGFR) DMQXYE9 MT DTT DMQXYE9 MA Inhibitor DMQXYE9 RN Tyrosine kinase inhibitors. 10. Isomeric 4-[(3-bromophenyl)amino]pyrido[d]-pyrimidines are potent ATP binding site inhibitors of the tyrosine kinas... J Med Chem. 1996 Apr 26;39(9):1823-35. DMQXYE9 RU https://pubmed.ncbi.nlm.nih.gov/8627606 DM6RVTO DI DM6RVTO DM6RVTO DN PD159790 DM6RVTO MI TTQ9RYT DM6RVTO MN Endothelin-converting enzyme 1 (ECE1) DM6RVTO MT DTT DM6RVTO MA Inhibitor DM6RVTO RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1615). DM6RVTO RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1615 DMZYIKR DI DMZYIKR DMZYIKR DN PD-160946 DMZYIKR MI TTBPGLU DMZYIKR MN Neuromedin-K receptor (TACR3) DMZYIKR MT DTT DMZYIKR MA Inhibitor DMZYIKR RN The development of a novel series of non-peptide tachykinin NK3 receptor selective antagonists, Bioorg. Med. Chem. Lett. 5(16):1773-1778 (1995). DMZYIKR RU http://www.sciencedirect.com/science/article/pii/0960894X9500313I DM8NV2E DI DM8NV2E DM8NV2E DN PD-161182 DM8NV2E MI TTBPGLU DM8NV2E MN Neuromedin-K receptor (TACR3) DM8NV2E MT DTT DM8NV2E MA Inhibitor DM8NV2E RN The development of a novel series of non-peptide tachykinin NK3 receptor selective antagonists, Bioorg. Med. Chem. Lett. 5(16):1773-1778 (1995). DM8NV2E RU http://www.sciencedirect.com/science/article/pii/0960894X9500313I DMBZ09U DI DMBZ09U DMBZ09U DN PD-163140 DMBZ09U MI TTKRD0G DMBZ09U MN Endothelin A receptor (EDNRA) DMBZ09U MT DTT DMBZ09U MA Inhibitor DMBZ09U RN gamma-Carbamate butenolide analogues as potent ETA selective endothelin receptor antagonists and prodrugs, Bioorg. Med. Chem. Lett. 7(3):297-302 (1997). DMBZ09U RU http://www.sciencedirect.com/science/article/pii/S0960894X97000024 DMBZ09U DI DMBZ09U DMBZ09U DN PD-163140 DMBZ09U MI TT3ZTGU DMBZ09U MN Endothelin B receptor (EDNRB) DMBZ09U MT DTT DMBZ09U MA Inhibitor DMBZ09U RN gamma-Carbamate butenolide analogues as potent ETA selective endothelin receptor antagonists and prodrugs, Bioorg. Med. Chem. Lett. 7(3):297-302 (1997). DMBZ09U RU http://www.sciencedirect.com/science/article/pii/S0960894X97000024 DM5421R DI DM5421R DM5421R DN PD164333 DM5421R MI TTKRD0G DM5421R MN Endothelin A receptor (EDNRA) DM5421R MT DTT DM5421R MA Antagonist DM5421R RN Characterization of [125I]-PD164333, an ETA selective non-peptide radiolabelled antagonist, in normal and diseased human tissues. Br J Pharmacol. 1998 Jan;123(2):223-30. DM5421R RU https://pubmed.ncbi.nlm.nih.gov/9489609 DM9LJEP DI DM9LJEP DM9LJEP DN PD-167341 DM9LJEP MI TT4FDG6 DM9LJEP MN Voltage-gated calcium channel alpha Cav2.2 (CACNA1B) DM9LJEP MT DTT DM9LJEP MA Inhibitor DM9LJEP RN Synthesis of a series of 4-benzyloxyaniline analogues as neuronal N-type calcium channel blockers with improved anticonvulsant and analgesic proper... J Med Chem. 1999 Oct 7;42(20):4239-49. DM9LJEP RU https://pubmed.ncbi.nlm.nih.gov/10514294 DMX1AY4 DI DMX1AY4 DMX1AY4 DN PD-168077 DMX1AY4 MI TTEX248 DMX1AY4 MN Dopamine D2 receptor (D2R) DMX1AY4 MT DTT DMX1AY4 MA Inhibitor DMX1AY4 RN New N-n-propyl-substituted 3-aryl- and 3-cyclohexylpiperidines as partial agonists at the D4 dopamine receptor. J Med Chem. 2003 Jan 2;46(1):161-8. DMX1AY4 RU https://pubmed.ncbi.nlm.nih.gov/12502370 DMN8M5P DI DMN8M5P DMN8M5P DN PD-168393 DMN8M5P MI TTGKNB4 DMN8M5P MN Epidermal growth factor receptor (EGFR) DMN8M5P MT DTT DMN8M5P MA Inhibitor DMN8M5P RN Structure-guided development of affinity probes for tyrosine kinases using chemical genetics. Nat Chem Biol. 2007 Apr;3(4):229-38. DMN8M5P RU https://pubmed.ncbi.nlm.nih.gov/17334377 DMN8M5P DI DMN8M5P DMN8M5P DN PD-168393 DMN8M5P MI TTR5TV4 DMN8M5P MN ERBB2 messenger RNA (HER2 mRNA) DMN8M5P MT DTT DMN8M5P MA Inhibitor DMN8M5P RN Tyrosine kinase inhibitors. 15. 4-(Phenylamino)quinazoline and 4-(phenylamino)pyrido[d]pyrimidine acrylamides as irreversible inhibitors of the ATP... J Med Chem. 1999 May 20;42(10):1803-15. DMN8M5P RU https://pubmed.ncbi.nlm.nih.gov/10346932 DM1Z3D7 DI DM1Z3D7 DM1Z3D7 DN PD-169316 DM1Z3D7 MI TTSJ6Q4 DM1Z3D7 MN LOX-5 messenger RNA (ALOX5 mRNA) DM1Z3D7 MT DTT DM1Z3D7 MA Inhibitor DM1Z3D7 RN 2,4,5- triarylimidazole inhibitors of IL-1 biosynthesis, Bioorg. Med. Chem. Lett. 5(11):1171-1176 (1995). DM1Z3D7 RU http://www.sciencedirect.com/science/article/pii/0960894X9500189Z DMU3OR1 DI DMU3OR1 DMU3OR1 DN PD-169469 DMU3OR1 MI TTLM12X DMU3OR1 MN Matrix metalloproteinase-2 (MMP-2) DMU3OR1 MT DTT DMU3OR1 MA Inhibitor DMU3OR1 RN Structural insight into the stereoselective inhibition of MMP-8 by enantiomeric sulfonamide phosphonates. J Med Chem. 2006 Feb 9;49(3):923-31. DMU3OR1 RU https://pubmed.ncbi.nlm.nih.gov/16451058 DMU3OR1 DI DMU3OR1 DMU3OR1 DN PD-169469 DMU3OR1 MI TTUZ2L5 DMU3OR1 MN Matrix metalloproteinase-3 (MMP-3) DMU3OR1 MT DTT DMU3OR1 MA Inhibitor DMU3OR1 RN Structural insight into the stereoselective inhibition of MMP-8 by enantiomeric sulfonamide phosphonates. J Med Chem. 2006 Feb 9;49(3):923-31. DMU3OR1 RU https://pubmed.ncbi.nlm.nih.gov/16451058 DMJ3DOI DI DMJ3DOI DMJ3DOI DN PD-171729 DMJ3DOI MI TT7EFHR DMJ3DOI MN Corticotropin-releasing factor receptor 1 (CRHR1) DMJ3DOI MT DTT DMJ3DOI MA Inhibitor DMJ3DOI RN Pyrazolo[1,5-a]pyrimidine CRF-1 receptor antagonists. Bioorg Med Chem Lett. 1998 Aug 18;8(16):2067-70. DMJ3DOI RU https://pubmed.ncbi.nlm.nih.gov/9873487 DM29GUY DI DM29GUY DM29GUY DN PD-172938 DM29GUY MI TTEX248 DM29GUY MN Dopamine D2 receptor (D2R) DM29GUY MT DTT DM29GUY MA Inhibitor DM29GUY RN Isoindolinone enantiomers having affinity for the dopamine D4 receptor. Bioorg Med Chem Lett. 1998 Jun 16;8(12):1499-502. DM29GUY RU https://pubmed.ncbi.nlm.nih.gov/9873377 DMI8JTE DI DMI8JTE DMI8JTE DN PD-172939 DMI8JTE MI TTEX248 DMI8JTE MN Dopamine D2 receptor (D2R) DMI8JTE MT DTT DMI8JTE MA Inhibitor DMI8JTE RN Isoindolinone enantiomers having affinity for the dopamine D4 receptor. Bioorg Med Chem Lett. 1998 Jun 16;8(12):1499-502. DMI8JTE RU https://pubmed.ncbi.nlm.nih.gov/9873377 DMP0N4U DI DMP0N4U DMP0N4U DN PD173074 DMP0N4U MI TT0LF7H DMP0N4U MN Fibroblast growth factor receptor (FGFR) DMP0N4U MT DTT DMP0N4U MA Antagonist DMP0N4U RN Tumor angiogenesis as a therapeutic target. Drug Discov Today. 2001 Oct 1;6(19):1005-1024. DMP0N4U RU https://pubmed.ncbi.nlm.nih.gov/11576867 DMP0N4U DI DMP0N4U DMP0N4U DN PD173074 DMP0N4U MI TTFPD8J DMP0N4U MN Fusion protein FGFR3-TACC3 (FGFR3-TACC3) DMP0N4U MT DTT DMP0N4U MA Inhibitor DMP0N4U RN Recurrent FGFR3-TACC3 fusion gene in nasopharyngeal carcinoma.Cancer Biol Ther. 2014;15(12):1613-21. DMP0N4U RU https://pubmed.ncbi.nlm.nih.gov/25535896 DMP0N4U DI DMP0N4U DMP0N4U DN PD173074 DMP0N4U MI TT6PKBN DMP0N4U MN Proto-oncogene c-Src (SRC) DMP0N4U MT DTT DMP0N4U MA Inhibitor DMP0N4U RN Anti-angiogenic activity of selected receptor tyrosine kinase inhibitors, PD166285 and PD173074: implications for combination treatment with photodynamic therapy. Invest New Drugs. 1999;17(2):121-35. DMP0N4U RU https://pubmed.ncbi.nlm.nih.gov/10638483 DMRBKW6 DI DMRBKW6 DMRBKW6 DN PD173212 DMRBKW6 MI TTXHYV6 DMRBKW6 MN Voltage-gated L-type calcium channel (L-CaC) DMRBKW6 MT DTT DMRBKW6 MA Blocker DMRBKW6 RN Recent updates of N-type calcium channel blockers with therapeutic potential for neuropathic pain and stroke. Curr Top Med Chem. 2009;9(4):377-95. DMRBKW6 RU https://pubmed.ncbi.nlm.nih.gov/19442208 DMBHIAK DI DMBHIAK DMBHIAK DN PD-174265 DMBHIAK MI TT6PKBN DMBHIAK MN Proto-oncogene c-Src (SRC) DMBHIAK MT DTT DMBHIAK MA Inhibitor DMBHIAK RN Hybrid compound design to overcome the gatekeeper T338M mutation in cSrc. J Med Chem. 2009 Jul 9;52(13):3915-26. DMBHIAK RU https://pubmed.ncbi.nlm.nih.gov/19462975 DM6XHUZ DI DM6XHUZ DM6XHUZ DN PD176078 DM6XHUZ MI TTXHYV6 DM6XHUZ MN Voltage-gated L-type calcium channel (L-CaC) DM6XHUZ MT DTT DM6XHUZ MA Blocker DM6XHUZ RN Recent updates of N-type calcium channel blockers with therapeutic potential for neuropathic pain and stroke. Curr Top Med Chem. 2009;9(4):377-95. DM6XHUZ RU https://pubmed.ncbi.nlm.nih.gov/19442208 DMXLW4F DI DMXLW4F DMXLW4F DN PD182905 DMXLW4F MI TTGKNB4 DMXLW4F MN Epidermal growth factor receptor (EGFR) DMXLW4F MT DTT DMXLW4F MA Inhibitor DMXLW4F RN Growth factors and their receptors: new targets for prostate cancer therapy. Urology. 2001 Aug;58(2 Suppl 1):114-22. DMXLW4F RU https://pubmed.ncbi.nlm.nih.gov/11502465 DMLU9P6 DI DMLU9P6 DMLU9P6 DN PD-307243 DMLU9P6 MI TTQ6VDM DMLU9P6 MN Voltage-gated potassium channel Kv11.1 (KCNH2) DMLU9P6 MT DTT DMLU9P6 MA Activator DMLU9P6 RN 2-[2-(3,4-dichloro-phenyl)-2,3-dihydro-1H-isoindol-5-ylamino]-nicotinic acid (PD-307243) causes instantaneous current through human ether-a-go-go-r... Mol Pharmacol. 2008 Mar;73(3):639-51. DMLU9P6 RU https://pubmed.ncbi.nlm.nih.gov/18042732 DMBA15J DI DMBA15J DMBA15J DN PD-32577 DMBA15J MI TTZIFHC DMBA15J MN Voltage-gated calcium channel alpha Cav1.2 (CACNA1C) DMBA15J MT DTT DMBA15J MA Inhibitor DMBA15J RN Synthesis and biological activity of substituted bis-(4-hydroxyphenyl)methanes as N-type calcium channel blockers. Bioorg Med Chem Lett. 1999 Aug 16;9(16):2447-52. DMBA15J RU https://pubmed.ncbi.nlm.nih.gov/10476885 DMBA15J DI DMBA15J DMBA15J DN PD-32577 DMBA15J MI TT7RGTM DMBA15J MN Voltage-gated calcium channel alpha Cav1.3 (CACNA1D) DMBA15J MT DTT DMBA15J MA Inhibitor DMBA15J RN Synthesis and biological activity of substituted bis-(4-hydroxyphenyl)methanes as N-type calcium channel blockers. Bioorg Med Chem Lett. 1999 Aug 16;9(16):2447-52. DMBA15J RU https://pubmed.ncbi.nlm.nih.gov/10476885 DMBA15J DI DMBA15J DMBA15J DN PD-32577 DMBA15J MI TT4FDG6 DMBA15J MN Voltage-gated calcium channel alpha Cav2.2 (CACNA1B) DMBA15J MT DTT DMBA15J MA Inhibitor DMBA15J RN Synthesis and biological activity of substituted bis-(4-hydroxyphenyl)methanes as N-type calcium channel blockers. Bioorg Med Chem Lett. 1999 Aug 16;9(16):2447-52. DMBA15J RU https://pubmed.ncbi.nlm.nih.gov/10476885 DMBA15J DI DMBA15J DMBA15J DN PD-32577 DMBA15J MI TTPXI3S DMBA15J MN Voltage-gated potassium channel Kv7.2 (KCNQ2) DMBA15J MT DTT DMBA15J MA Inhibitor DMBA15J RN Synthesis and biological activity of substituted bis-(4-hydroxyphenyl)methanes as N-type calcium channel blockers. Bioorg Med Chem Lett. 1999 Aug 16;9(16):2447-52. DMBA15J RU https://pubmed.ncbi.nlm.nih.gov/10476885 DMBA15J DI DMBA15J DMBA15J DN PD-32577 DMBA15J MI TTIVDM3 DMBA15J MN Voltage-gated potassium channel Kv7.3 (KCNQ3) DMBA15J MT DTT DMBA15J MA Inhibitor DMBA15J RN Synthesis and biological activity of substituted bis-(4-hydroxyphenyl)methanes as N-type calcium channel blockers. Bioorg Med Chem Lett. 1999 Aug 16;9(16):2447-52. DMBA15J RU https://pubmed.ncbi.nlm.nih.gov/10476885 DMBA15J DI DMBA15J DMBA15J DN PD-32577 DMBA15J MI TT90XZ8 DMBA15J MN Voltage-gated sodium channel alpha Nav1.8 (SCN10A) DMBA15J MT DTT DMBA15J MA Inhibitor DMBA15J RN Synthesis and biological activity of substituted bis-(4-hydroxyphenyl)methanes as N-type calcium channel blockers. Bioorg Med Chem Lett. 1999 Aug 16;9(16):2447-52. DMBA15J RU https://pubmed.ncbi.nlm.nih.gov/10476885 DMBA15J DI DMBA15J DMBA15J DN PD-32577 DMBA15J MI TTN9VTF DMBA15J MN Voltage-gated sodium channel alpha Nav1.9 (SCN11A) DMBA15J MT DTT DMBA15J MA Inhibitor DMBA15J RN Synthesis and biological activity of substituted bis-(4-hydroxyphenyl)methanes as N-type calcium channel blockers. Bioorg Med Chem Lett. 1999 Aug 16;9(16):2447-52. DMBA15J RU https://pubmed.ncbi.nlm.nih.gov/10476885 DM0OEH3 DI DM0OEH3 DM0OEH3 DN PD-4048 DM0OEH3 MI TTJ6WK9 DM0OEH3 MN Neuropeptide Y receptor type 2 (NPY2R) DM0OEH3 MT DTT DM0OEH3 MA Agonist DM0OEH3 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 306). DM0OEH3 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=306 DM4BDEY DI DM4BDEY DM4BDEY DN PD-4074 DM4BDEY MI TTW4N16 DM4BDEY MN Neuropeptide Y receptor type 4 (NPY4R) DM4BDEY MT DTT DM4BDEY MA Agonist DM4BDEY RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 307). DM4BDEY RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=307 DM5SYTW DI DM5SYTW DM5SYTW DN PD-81723 DM5SYTW MI TTK25J1 DM5SYTW MN Adenosine A1 receptor (ADORA1) DM5SYTW MT DTT DM5SYTW MA Inhibitor DM5SYTW RN Synthesis and biological evaluation of 2-amino-3-(4-chlorobenzoyl)-4-[N-(substituted) piperazin-1-yl]thiophenes as potent allosteric enhancers of t... J Med Chem. 2008 Sep 25;51(18):5875-9. DM5SYTW RU https://pubmed.ncbi.nlm.nih.gov/18729349 DMSIMKZ DI DMSIMKZ DMSIMKZ DN PD-83176 DMSIMKZ MI TT7WZIJ DMSIMKZ MN CAAX farnesyltransferase beta (FNTB) DMSIMKZ MT DTT DMSIMKZ MA Inhibitor DMSIMKZ RN Structure-activity relationships of cysteine-lacking pentapeptide derivatives that inhibit ras farnesyltransferase. J Med Chem. 1997 Jan 17;40(2):192-200. DMSIMKZ RU https://pubmed.ncbi.nlm.nih.gov/9003517 DMSIMKZ DI DMSIMKZ DMSIMKZ DN PD-83176 DMSIMKZ MI TTXQKM3 DMSIMKZ MN Farnesyl protein transferase (Ftase) DMSIMKZ MT DTT DMSIMKZ MA Inhibitor DMSIMKZ RN Structure-activity relationships of cysteine-lacking pentapeptide derivatives that inhibit ras farnesyltransferase. J Med Chem. 1997 Jan 17;40(2):192-200. DMSIMKZ RU https://pubmed.ncbi.nlm.nih.gov/9003517 DMSIMKZ DI DMSIMKZ DMSIMKZ DN PD-83176 DMSIMKZ MI TTX20QP DMSIMKZ MN Geranylgeranyl transferase I (GGTase-I) DMSIMKZ MT DTT DMSIMKZ MA Inhibitor DMSIMKZ RN Structure-activity relationships of cysteine-lacking pentapeptide derivatives that inhibit ras farnesyltransferase. J Med Chem. 1997 Jan 17;40(2):192-200. DMSIMKZ RU https://pubmed.ncbi.nlm.nih.gov/9003517 DMZC90M DI DMZC90M DMZC90M DN PD98059 DMZC90M MI TTIDAPM DMZC90M MN ERK activator kinase 1 (MEK1) DMZC90M MT DTT DMZC90M MA Inhibitor DMZC90M RN The MEK1 inhibitor PD98059 sensitizes C8161 melanoma cells to cisplatin-induced apoptosis. Melanoma Res. 2001 Feb;11(1):11-9. DMZC90M RU https://pubmed.ncbi.nlm.nih.gov/11254111 DMZC90M DI DMZC90M DMZC90M DN PD98059 DMZC90M MI TTTW2NY DMZC90M MN ERK activator kinase 2 (MEK2) DMZC90M MT DTT DMZC90M MA Inhibitor DMZC90M RN The MEK1 inhibitor PD98059 sensitizes C8161 melanoma cells to cisplatin-induced apoptosis. Melanoma Res. 2001 Feb;11(1):11-9. DMZC90M RU https://pubmed.ncbi.nlm.nih.gov/11254111 DMUDY7H DI DMUDY7H DMUDY7H DN PDC-31 DMUDY7H MI TTT2ZAR DMUDY7H MN Prostaglandin F2-alpha receptor (PTGFR) DMUDY7H MT DTT DMUDY7H MA Antagonist DMUDY7H RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 344). DMUDY7H RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=344 DMSO3HM DI DMSO3HM DMSO3HM DN PDGF gene therapy DMSO3HM MI TTI2WET DMSO3HM MN Platelet-derived growth factor receptor (PDGFR) DMSO3HM MT DTT DMSO3HM MA Activator DMSO3HM RN Emerging drugs for diabetic foot ulcers. Expert Opin Emerg Drugs. 2006 Nov;11(4):709-24. DMSO3HM RU https://pubmed.ncbi.nlm.nih.gov/17064227 DMORLTH DI DMORLTH DMORLTH DN PDGF receptor tyrosine kinase inhibitor III DMORLTH MI TTI7421 DMORLTH MN Platelet-derived growth factor receptor beta (PDGFRB) DMORLTH MT DTT DMORLTH MA Inhibitor DMORLTH RN Potent and selective inhibitors of platelet-derived growth factor receptor phosphorylation. 3. Replacement of quinazoline moiety and improvement of metabolic polymorphism of 4-[4-(N-substituted (thio)carbamoyl)-1-piperazinyl]-6,7-dimethoxyquinazoline derivatives. J Med Chem. 2003 Nov 6;46(23):4910-25. DMORLTH RU https://pubmed.ncbi.nlm.nih.gov/14584942 DMKLRCX DI DMKLRCX DMKLRCX DN Pedunculagin DMKLRCX MI TT6L509 DMKLRCX MN Coagulation factor IIa (F2) DMKLRCX MT DTT DMKLRCX MA Inhibitor DMKLRCX RN Effects of tannins from Geum japonicum on the catalytic activity of thrombin and factor Xa of blood coagulation cascade. J Nat Prod. 1998 Nov;61(11):1356-60. DMKLRCX RU https://pubmed.ncbi.nlm.nih.gov/9834152 DMKLRCX DI DMKLRCX DMKLRCX DN Pedunculagin DMKLRCX MI TTCIHJA DMKLRCX MN Coagulation factor Xa (F10) DMKLRCX MT DTT DMKLRCX MA Inhibitor DMKLRCX RN Effects of tannins from Geum japonicum on the catalytic activity of thrombin and factor Xa of blood coagulation cascade. J Nat Prod. 1998 Nov;61(11):1356-60. DMKLRCX RU https://pubmed.ncbi.nlm.nih.gov/9834152 DMKLRCX DI DMKLRCX DMKLRCX DN Pedunculagin DMKLRCX MI TTE14XG DMKLRCX MN Squalene monooxygenase (SQLE) DMKLRCX MT DTT DMKLRCX MA Inhibitor DMKLRCX RN Ellagitannins and hexahydroxydiphenoyl esters as inhibitors of vertebrate squalene epoxidase. J Nat Prod. 2001 Aug;64(8):1010-4. DMKLRCX RU https://pubmed.ncbi.nlm.nih.gov/11520216 DM5GVZJ DI DM5GVZJ DM5GVZJ DN PEG-EPO DM5GVZJ MI TTAUX24 DM5GVZJ MN Erythropoietin Receptor (EPOR) DM5GVZJ MT DTT DM5GVZJ MA Stimulator DM5GVZJ RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1718). DM5GVZJ RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1718 DMY293M DI DMY293M DMY293M DN PEG-LPA-2 DMY293M MI TT0HD6V DMY293M MN Leptin receptor (LEPR) DMY293M MT DTT DMY293M MA Antagonist DMY293M RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1712). DMY293M RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1712 DMZ01PS DI DMZ01PS DMZ01PS DN PEGylated leptin DMZ01PS MI TT0HD6V DMZ01PS MN Leptin receptor (LEPR) DMZ01PS MT DTT DMZ01PS MA Modulator DMZ01PS RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1712). DMZ01PS RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1712 DM6K3G7 DI DM6K3G7 DM6K3G7 DN PEGylated PYY-3-36 DM6K3G7 MI TTJ6WK9 DM6K3G7 MN Neuropeptide Y receptor type 2 (NPY2R) DM6K3G7 MT DTT DM6K3G7 MA Modulator DM6K3G7 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 306). DM6K3G7 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=306 DMAW0R7 DI DMAW0R7 DMAW0R7 DN PELARGONIDIN CHLORIDE DMAW0R7 MI TTV9A7R DMAW0R7 MN Lactoylglutathione lyase (GLO1) DMAW0R7 MT DTT DMAW0R7 MA Inhibitor DMAW0R7 RN Delphinidin, a dietary anthocyanidin in berry fruits, inhibits human glyoxalase I. Bioorg Med Chem. 2010 Oct 1;18(19):7029-33. DMAW0R7 RU https://pubmed.ncbi.nlm.nih.gov/20801663 DMYIWBD DI DMYIWBD DMYIWBD DN Pellitorin DMYIWBD MI TTA1L39 DMYIWBD MN ICAM1 messenger RNA (ICAM1 mRNA) DMYIWBD MT DTT DMYIWBD MA Inhibitor DMYIWBD RN Alkamides from the fruits of Piper longum and Piper nigrum displaying potent cell adhesion inhibition. Bioorg Med Chem Lett. 2008 Aug 15;18(16):4544-6. DMYIWBD RU https://pubmed.ncbi.nlm.nih.gov/18672369 DM81AWU DI DM81AWU DM81AWU DN Pen(Acm)AQFRKEKETFC(Acm)-OH DM81AWU MI TTJDUNO DM81AWU MN T-cell surface antigen CD2 (CD2) DM81AWU MT DTT DM81AWU MA Inhibitor DM81AWU RN Structure-activity studies of peptides from the "hot-spot" region of human CD2 protein: development of peptides for immunomodulation. J Med Chem. 2005 Oct 6;48(20):6236-49. DM81AWU RU https://pubmed.ncbi.nlm.nih.gov/16190751 DMZ3WPN DI DMZ3WPN DMZ3WPN DN Penciclovir DMZ3WPN MI TTV1095 DMZ3WPN MN COVID-19 RNA-directed RNA polymerase (RdRp) DMZ3WPN MT DTT DMZ3WPN MA Inhibitor DMZ3WPN RN Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro. Cell Res. 2020 Mar;30(3):269-271. DMZ3WPN RU https://pubmed.ncbi.nlm.nih.gov/32020029 DMIDSJ9 DI DMIDSJ9 DMIDSJ9 DN PENECA DMIDSJ9 MI TTK25J1 DMIDSJ9 MN Adenosine A1 receptor (ADORA1) DMIDSJ9 MT DTT DMIDSJ9 MA Agonist DMIDSJ9 RN N(6)-alkyl-2-alkynyl derivatives of adenosine as potent and selective agonists at the human adenosine A(3) receptor and a starting point for searching A(2B) ligands. J Med Chem. 2002 Jul 18;45(15):3271-9. DMIDSJ9 RU https://pubmed.ncbi.nlm.nih.gov/12109910 DMIDSJ9 DI DMIDSJ9 DMIDSJ9 DN PENECA DMIDSJ9 MI TTNE7KG DMIDSJ9 MN Adenosine A2b receptor (ADORA2B) DMIDSJ9 MT DTT DMIDSJ9 MA Agonist DMIDSJ9 RN N(6)-alkyl-2-alkynyl derivatives of adenosine as potent and selective agonists at the human adenosine A(3) receptor and a starting point for searching A(2B) ligands. J Med Chem. 2002 Jul 18;45(15):3271-9. DMIDSJ9 RU https://pubmed.ncbi.nlm.nih.gov/12109910 DMIDSJ9 DI DMIDSJ9 DMIDSJ9 DN PENECA DMIDSJ9 MI TTJFY5U DMIDSJ9 MN Adenosine A3 receptor (ADORA3) DMIDSJ9 MT DTT DMIDSJ9 MA Agonist DMIDSJ9 RN N(6)-alkyl-2-alkynyl derivatives of adenosine as potent and selective agonists at the human adenosine A(3) receptor and a starting point for searching A(2B) ligands. J Med Chem. 2002 Jul 18;45(15):3271-9. DMIDSJ9 RU https://pubmed.ncbi.nlm.nih.gov/12109910 DMZUES2 DI DMZUES2 DMZUES2 DN PENICILLIOL A DMZUES2 MI TTIU7X1 DMZUES2 MN Herpes simplex virus DNA polymerase UL30 (HSV UL30) DMZUES2 MT DTT DMZUES2 MA Inhibitor DMZUES2 RN Penicilliols A and B, novel inhibitors specific to mammalian Y-family DNA polymerases. Bioorg Med Chem. 2009 Mar 1;17(5):1811-6. DMZUES2 RU https://pubmed.ncbi.nlm.nih.gov/19223184 DMA13KG DI DMA13KG DMA13KG DN Pentamycin DMA13KG MI DEW6V07 DMA13KG MN Ribosomal 23S RNA methyltransferase Erm (erm) DMA13KG MT DME DMA13KG MA Metabolism DMA13KG RN High frequency of macrolide resistance mechanisms in clinical isolates of Corynebacterium species. Microb Drug Resist. 2010 Dec;16(4):273-7. DMA13KG RU https://pubmed.ncbi.nlm.nih.gov/20624090 DMA13KG DI DMA13KG DMA13KG DN Pentamycin DMA13KG MI DEA65D8 DMA13KG MN Ribosomal 23S RNA methyltransferase Erm (erm) DMA13KG MT DME DMA13KG MA Metabolism DMA13KG RN High frequency of macrolide resistance mechanisms in clinical isolates of Corynebacterium species. Microb Drug Resist. 2010 Dec;16(4):273-7. DMA13KG RU https://pubmed.ncbi.nlm.nih.gov/20624090 DMVPZG9 DI DMVPZG9 DMVPZG9 DN Pentane-1,5-diamine DMVPZG9 MI TTUNARX DMVPZG9 MN Carbonic anhydrase (CA) DMVPZG9 MT DTT DMVPZG9 MA Inhibitor DMVPZG9 RN Polyamines inhibit carbonic anhydrases by anchoring to the zinc-coordinated water molecule. J Med Chem. 2010 Aug 12;53(15):5511-22. DMVPZG9 RU https://pubmed.ncbi.nlm.nih.gov/20590092 DMVPZG9 DI DMVPZG9 DMVPZG9 DN Pentane-1,5-diamine DMVPZG9 MI TTHQPL7 DMVPZG9 MN Carbonic anhydrase I (CA-I) DMVPZG9 MT DTT DMVPZG9 MA Inhibitor DMVPZG9 RN Polyamines inhibit carbonic anhydrases by anchoring to the zinc-coordinated water molecule. J Med Chem. 2010 Aug 12;53(15):5511-22. DMVPZG9 RU https://pubmed.ncbi.nlm.nih.gov/20590092 DMVPZG9 DI DMVPZG9 DMVPZG9 DN Pentane-1,5-diamine DMVPZG9 MI TTANPDJ DMVPZG9 MN Carbonic anhydrase II (CA-II) DMVPZG9 MT DTT DMVPZG9 MA Inhibitor DMVPZG9 RN Polyamines inhibit carbonic anhydrases by anchoring to the zinc-coordinated water molecule. J Med Chem. 2010 Aug 12;53(15):5511-22. DMVPZG9 RU https://pubmed.ncbi.nlm.nih.gov/20590092 DMVPZG9 DI DMVPZG9 DMVPZG9 DN Pentane-1,5-diamine DMVPZG9 MI TTZHA0O DMVPZG9 MN Carbonic anhydrase IV (CA-IV) DMVPZG9 MT DTT DMVPZG9 MA Inhibitor DMVPZG9 RN Polyamines inhibit carbonic anhydrases by anchoring to the zinc-coordinated water molecule. J Med Chem. 2010 Aug 12;53(15):5511-22. DMVPZG9 RU https://pubmed.ncbi.nlm.nih.gov/20590092 DMVPZG9 DI DMVPZG9 DMVPZG9 DN Pentane-1,5-diamine DMVPZG9 MI TT2LVK8 DMVPZG9 MN Carbonic anhydrase IX (CA-IX) DMVPZG9 MT DTT DMVPZG9 MA Inhibitor DMVPZG9 RN Polyamines inhibit carbonic anhydrases by anchoring to the zinc-coordinated water molecule. J Med Chem. 2010 Aug 12;53(15):5511-22. DMVPZG9 RU https://pubmed.ncbi.nlm.nih.gov/20590092 DMVPZG9 DI DMVPZG9 DMVPZG9 DN Pentane-1,5-diamine DMVPZG9 MI TTCFSPE DMVPZG9 MN Carbonic anhydrase VI (CA-VI) DMVPZG9 MT DTT DMVPZG9 MA Inhibitor DMVPZG9 RN Polyamines inhibit carbonic anhydrases by anchoring to the zinc-coordinated water molecule. J Med Chem. 2010 Aug 12;53(15):5511-22. DMVPZG9 RU https://pubmed.ncbi.nlm.nih.gov/20590092 DMVPZG9 DI DMVPZG9 DMVPZG9 DN Pentane-1,5-diamine DMVPZG9 MI TTSYM0R DMVPZG9 MN Carbonic anhydrase XII (CA-XII) DMVPZG9 MT DTT DMVPZG9 MA Inhibitor DMVPZG9 RN Polyamines inhibit carbonic anhydrases by anchoring to the zinc-coordinated water molecule. J Med Chem. 2010 Aug 12;53(15):5511-22. DMVPZG9 RU https://pubmed.ncbi.nlm.nih.gov/20590092 DMVPZG9 DI DMVPZG9 DMVPZG9 DN Pentane-1,5-diamine DMVPZG9 MI TTEYTKG DMVPZG9 MN Carbonic anhydrase XIV (CA-XIV) DMVPZG9 MT DTT DMVPZG9 MA Inhibitor DMVPZG9 RN Polyamines inhibit carbonic anhydrases by anchoring to the zinc-coordinated water molecule. J Med Chem. 2010 Aug 12;53(15):5511-22. DMVPZG9 RU https://pubmed.ncbi.nlm.nih.gov/20590092 DM56RAX DI DM56RAX DM56RAX DN pentanoic acid DM56RAX MI TT0FYAN DM56RAX MN Free fatty acid receptor 2 (FFAR2) DM56RAX MT DTT DM56RAX MA Agonist DM56RAX RN The Orphan G protein-coupled receptors GPR41 and GPR43 are activated by propionate and other short chain carboxylic acids. J Biol Chem. 2003 Mar 28;278(13):11312-9. DM56RAX RU https://pubmed.ncbi.nlm.nih.gov/12496283 DM56RAX DI DM56RAX DM56RAX DN pentanoic acid DM56RAX MI TTXDOHN DM56RAX MN Free fatty acid receptor 3 (FFAR3) DM56RAX MT DTT DM56RAX MA Agonist DM56RAX RN Short-chain fatty acids stimulate leptin production in adipocytes through the G protein-coupled receptor GPR41. Proc Natl Acad Sci U S A. 2004 Jan 27;101(4):1045-50. DM56RAX RU https://pubmed.ncbi.nlm.nih.gov/14722361 DM3S790 DI DM3S790 DM3S790 DN Pentanoic acid (4,6-diphenylpyrimidin-2-yl)amide DM3S790 MI TTK25J1 DM3S790 MN Adenosine A1 receptor (ADORA1) DM3S790 MT DTT DM3S790 MA Inhibitor DM3S790 RN 2,4,6-trisubstituted pyrimidines as a new class of selective adenosine A1 receptor antagonists. J Med Chem. 2004 Dec 16;47(26):6529-40. DM3S790 RU https://pubmed.ncbi.nlm.nih.gov/15588088 DMAZ07T DI DMAZ07T DMAZ07T DN Pentanoic acid (4-sulfamoyl-phenyl)-amide DMAZ07T MI TTHQPL7 DMAZ07T MN Carbonic anhydrase I (CA-I) DMAZ07T MT DTT DMAZ07T MA Inhibitor DMAZ07T RN Carbonic anhydrase inhibitors: inhibition of the tumor-associated isozymes IX and XII with a library of aromatic and heteroaromatic sulfonamides. Bioorg Med Chem Lett. 2005 Nov 1;15(21):4862-6. DMAZ07T RU https://pubmed.ncbi.nlm.nih.gov/16168653 DMAZ07T DI DMAZ07T DMAZ07T DN Pentanoic acid (4-sulfamoyl-phenyl)-amide DMAZ07T MI TTANPDJ DMAZ07T MN Carbonic anhydrase II (CA-II) DMAZ07T MT DTT DMAZ07T MA Inhibitor DMAZ07T RN Carbonic anhydrase inhibitors: inhibition of the tumor-associated isozymes IX and XII with a library of aromatic and heteroaromatic sulfonamides. Bioorg Med Chem Lett. 2005 Nov 1;15(21):4862-6. DMAZ07T RU https://pubmed.ncbi.nlm.nih.gov/16168653 DMAZ07T DI DMAZ07T DMAZ07T DN Pentanoic acid (4-sulfamoyl-phenyl)-amide DMAZ07T MI TT2LVK8 DMAZ07T MN Carbonic anhydrase IX (CA-IX) DMAZ07T MT DTT DMAZ07T MA Inhibitor DMAZ07T RN Carbonic anhydrase inhibitors: inhibition of the tumor-associated isozymes IX and XII with a library of aromatic and heteroaromatic sulfonamides. Bioorg Med Chem Lett. 2005 Nov 1;15(21):4862-6. DMAZ07T RU https://pubmed.ncbi.nlm.nih.gov/16168653 DMAZ07T DI DMAZ07T DMAZ07T DN Pentanoic acid (4-sulfamoyl-phenyl)-amide DMAZ07T MI TTSYM0R DMAZ07T MN Carbonic anhydrase XII (CA-XII) DMAZ07T MT DTT DMAZ07T MA Inhibitor DMAZ07T RN Carbonic anhydrase inhibitors: inhibition of the tumor-associated isozymes IX and XII with a library of aromatic and heteroaromatic sulfonamides. Bioorg Med Chem Lett. 2005 Nov 1;15(21):4862-6. DMAZ07T RU https://pubmed.ncbi.nlm.nih.gov/16168653 DMD8NHB DI DMD8NHB DMD8NHB DN pentylthio-TZTP DMD8NHB MI TTOXS3C DMD8NHB MN Muscarinic acetylcholine receptor (CHRM) DMD8NHB MT DTT DMD8NHB MA Agonist DMD8NHB RN Positive cooperativity of acetylcholine and other agonists with allosteric ligands on muscarinic acetylcholine receptors. Mol Pharmacol. 1997 Jul;52(1):172-9. DMD8NHB RU https://pubmed.ncbi.nlm.nih.gov/9224827 DMD8NHB DI DMD8NHB DMD8NHB DN pentylthio-TZTP DMD8NHB MI TTQ13Z5 DMD8NHB MN Muscarinic acetylcholine receptor M3 (CHRM3) DMD8NHB MT DTT DMD8NHB MA Agonist DMD8NHB RN Positive cooperativity of acetylcholine and other agonists with allosteric ligands on muscarinic acetylcholine receptors. Mol Pharmacol. 1997 Jul;52(1):172-9. DMD8NHB RU https://pubmed.ncbi.nlm.nih.gov/9224827 DMIDP1R DI DMIDP1R DMIDP1R DN peptide 18 DMIDP1R MI TTH9WF6 DMIDP1R MN Dibasic-processing enzyme (Furin) DMIDP1R MT DTT DMIDP1R MA Inhibitor DMIDP1R RN Design, synthesis, and structure-activity relationship studies of a potent PACE4 inhibitor. J Med Chem. 2014 Jan 9;57(1):98-109. DMIDP1R RU https://pubmed.ncbi.nlm.nih.gov/24350995 DMIDP1R DI DMIDP1R DMIDP1R DN peptide 18 DMIDP1R MI TT46F0P DMIDP1R MN Neuroendocrine convertase 2 (PCSK2) DMIDP1R MT DTT DMIDP1R MA Inhibitor DMIDP1R RN Design, synthesis, and structure-activity relationship studies of a potent PACE4 inhibitor. J Med Chem. 2014 Jan 9;57(1):98-109. DMIDP1R RU https://pubmed.ncbi.nlm.nih.gov/24350995 DMIDP1R DI DMIDP1R DMIDP1R DN peptide 18 DMIDP1R MI TT75LN9 DMIDP1R MN Proprotein convertase subtilisin/kexin type 6 (PCSK6) DMIDP1R MT DTT DMIDP1R MA Inhibitor DMIDP1R RN Design, synthesis, and structure-activity relationship studies of a potent PACE4 inhibitor. J Med Chem. 2014 Jan 9;57(1):98-109. DMIDP1R RU https://pubmed.ncbi.nlm.nih.gov/24350995 DMIDP1R DI DMIDP1R DMIDP1R DN peptide 18 DMIDP1R MI TTD30LY DMIDP1R MN Proprotein convertase subtilisin/kexin type 7 (PCSK7) DMIDP1R MT DTT DMIDP1R MA Inhibitor DMIDP1R RN Design, synthesis, and structure-activity relationship studies of a potent PACE4 inhibitor. J Med Chem. 2014 Jan 9;57(1):98-109. DMIDP1R RU https://pubmed.ncbi.nlm.nih.gov/24350995 DM45RTZ DI DM45RTZ DM45RTZ DN peptide 4 DM45RTZ MI TTQ7R2V DM45RTZ MN Tripeptidyl-peptidase II (TPP2) DM45RTZ MT DTT DM45RTZ MA Inhibitor DM45RTZ RN Use of lantibiotic synthetases for the preparation of bioactive constrained peptides. Bioorg Med Chem Lett. 2008 May 15;18(10):3025-8. DM45RTZ RU https://pubmed.ncbi.nlm.nih.gov/18294843 DMC6GUA DI DMC6GUA DMC6GUA DN Peptide alpha-keto-beta-aldehyde-based inhibitors DMC6GUA MI TT36ETB DMC6GUA MN Cathepsin L (CTSL) DMC6GUA MT DTT DMC6GUA MA Inhibitor DMC6GUA RN Synthesis and kinetic evaluation of peptide alpha-keto-beta-aldehyde-based inhibitors of trypsin-like serine proteases. J Pharm Pharmacol. 2001 Apr;53(4):473-80. DMC6GUA RU https://pubmed.ncbi.nlm.nih.gov/11341363 DMSDFOC DI DMSDFOC DMSDFOC DN peptide III-BTD DMSDFOC MI TTNT7K8 DMSDFOC MN Nociceptin receptor (OPRL1) DMSDFOC MT DTT DMSDFOC MA Antagonist DMSDFOC RN Ligands for kappa-opioid and ORL1 receptors identified from a conformationally constrained peptide combinatorial library. J Biol Chem. 1999 Sep 24;274(39):27513-22. DMSDFOC RU https://pubmed.ncbi.nlm.nih.gov/10488086 DM8OC9F DI DM8OC9F DM8OC9F DN Pergularinine DM8OC9F MI TTS7IR5 DM8OC9F MN c-Jun messenger RNA (c-Jun mRNA) DM8OC9F MT DTT DM8OC9F MA Inhibitor DM8OC9F RN Structure-activity studies of phenanthroindolizidine alkaloids as potential antitumor agents. Bioorg Med Chem Lett. 2007 Aug 1;17(15):4338-42. DM8OC9F RU https://pubmed.ncbi.nlm.nih.gov/17531481 DM8OC9F DI DM8OC9F DM8OC9F DN Pergularinine DM8OC9F MI TT9SL3Q DM8OC9F MN Polypeptide deformylase (PDF) DM8OC9F MT DTT DM8OC9F MA Inhibitor DM8OC9F RN Inhibition of dihydrofolate reductase and cell growth activity by the phenanthroindolizidine alkaloids pergularinine and tylophorinidine: the in vitro cytotoxicity of these plant alkaloids and their potential as antimicrobial and anticancer agents. Toxicol In Vitro. 2000 Feb;14(1):53-9. DM8OC9F RU https://pubmed.ncbi.nlm.nih.gov/10699361 DMZA0VD DI DMZA0VD DMZA0VD DN Perillaldehyde DMZA0VD MI TTXDKTO DMZA0VD MN Long transient receptor potential channel 8 (TRPM8) DMZA0VD MT DTT DMZA0VD MA Inhibitor DMZA0VD RN Taste-guided identification of high potency TRPA1 agonists from Perilla frutescens. Bioorg Med Chem. 2009 Feb 15;17(4):1636-9. DMZA0VD RU https://pubmed.ncbi.nlm.nih.gov/19162486 DMN9W56 DI DMN9W56 DMN9W56 DN PERIPENTADENINE DMN9W56 MI TT27RFC DMN9W56 MN Opioid receptor delta (OPRD1) DMN9W56 MT DTT DMN9W56 MA Inhibitor DMN9W56 RN Alkaloids with human delta-opioid receptor binding affinity from the Australian rainforest tree Peripentadenia mearsii. J Nat Prod. 2007 Dec;70(12):1946-50. DMN9W56 RU https://pubmed.ncbi.nlm.nih.gov/18039010 DM3RGPF DI DM3RGPF DM3RGPF DN PERSICARIN DM3RGPF MI TT7RJY8 DM3RGPF MN Xanthine dehydrogenase/oxidase (XDH) DM3RGPF MT DTT DM3RGPF MA Inhibitor DM3RGPF RN Inhibition of cow's milk xanthine oxidase by flavonoids. J Nat Prod. 1988 Mar-Apr;51(2):345-8. DM3RGPF RU https://pubmed.ncbi.nlm.nih.gov/3379415 DM873BS DI DM873BS DM873BS DN Pervanadate DM873BS MI TTWC6MY DM873BS MN Protein tyrosine phosphatase (PTP) DM873BS MT DTT DM873BS MA Inhibitor DM873BS RN Induction of endothelial cell surface adhesion molecules by tumor necrosis factor is blocked by protein tyrosine phosphatase inhibitors: role of the nuclear transcription factor NF-kappa B. Eur J Immunol. 1997 Sep;27(9):2172-9. DM873BS RU https://pubmed.ncbi.nlm.nih.gov/9341756 DM0N1DH DI DM0N1DH DM0N1DH DN PETCM DM0N1DH MI TTPF2QI DM0N1DH MN Caspase-3 (CASP3) DM0N1DH MT DTT DM0N1DH MA Activator DM0N1DH RN Distinctive roles of PHAP proteins and prothymosin-alpha in a death regulatory pathway. Science. 2003 Jan 10;299(5604):223-6. DM0N1DH RU https://pubmed.ncbi.nlm.nih.gov/12522243 DMYIEOJ DI DMYIEOJ DMYIEOJ DN Petrosamine DMYIEOJ MI TT1RS9F DMYIEOJ MN Acetylcholinesterase (AChE) DMYIEOJ MT DTT DMYIEOJ MA Inhibitor DMYIEOJ RN Petrosamine, a potent anticholinesterase pyridoacridine alkaloid from a Thai marine sponge Petrosia n. sp. Bioorg Med Chem. 2008 Jul 1;16(13):6560-7. DMYIEOJ RU https://pubmed.ncbi.nlm.nih.gov/18538575 DMR8ZBT DI DMR8ZBT DMR8ZBT DN Petrosaspongiolide M DMR8ZBT MI TT9V5JH DMR8ZBT MN Phospholipase A2 (PLA2G1B) DMR8ZBT MT DTT DMR8ZBT MA Inhibitor DMR8ZBT RN Synthesis and pharmacological evaluation of a selected library of new potential anti-inflammatory agents bearing the gamma-hydroxybutenolide scaffo... J Med Chem. 2007 May 3;50(9):2176-84. DMR8ZBT RU https://pubmed.ncbi.nlm.nih.gov/17407277 DMMVZFN DI DMMVZFN DMMVZFN DN Petrosaspongiolide P DMMVZFN MI TT9V5JH DMMVZFN MN Phospholipase A2 (PLA2G1B) DMMVZFN MT DTT DMMVZFN MA Inhibitor DMMVZFN RN Petrosaspongiolides M-R: new potent and selective phospholipase A2 inhibitors from the New Caledonian marine sponge Petrosaspongia nigra. J Nat Prod. 1998 May;61(5):571-5. DMMVZFN RU https://pubmed.ncbi.nlm.nih.gov/9599251 DMY45K1 DI DMY45K1 DMY45K1 DN PF 5208766 DMY45K1 MI TTGKNB4 DMY45K1 MN Epidermal growth factor receptor (EGFR) DMY45K1 MT DTT DMY45K1 MA Modulator DMY45K1 RN Optimization of 6,7-disubstituted-4-(arylamino)quinoline-3-carbonitriles as orally active, irreversible inhibitors of human epidermal growth factor... J Med Chem. 2005 Feb 24;48(4):1107-31. DMY45K1 RU https://www.ncbi.nlm.nih.gov/pubmed/15715478 DMY45K1 DI DMY45K1 DMY45K1 DN PF 5208766 DMY45K1 MI TT6EO5L DMY45K1 MN Erbb2 tyrosine kinase receptor (HER2) DMY45K1 MT DTT DMY45K1 MA Modulator DMY45K1 RN Optimization of 6,7-disubstituted-4-(arylamino)quinoline-3-carbonitriles as orally active, irreversible inhibitors of human epidermal growth factor... J Med Chem. 2005 Feb 24;48(4):1107-31. DMY45K1 RU https://www.ncbi.nlm.nih.gov/pubmed/15715478 DMRHIMC DI DMRHIMC DMRHIMC DN PF-00212062 DMRHIMC MI TT1ZAVI DMRHIMC MN Prostaglandin E2 receptor EP2 (PTGER2) DMRHIMC MT DTT DMRHIMC MA Antagonist DMRHIMC RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 341). DMRHIMC RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=341 DMV43NF DI DMV43NF DMV43NF DN PF-00356231 DMV43NF MI TTXZ0KQ DMV43NF MN Matrix metalloproteinase-12 (MMP-12) DMV43NF MT DTT DMV43NF MA Inhibitor DMV43NF RN DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Nucleic Acids Res. 2011 Jan;39(Database issue):D1035-41. DMV43NF RU https://pubmed.ncbi.nlm.nih.gov/21059682 DMWL9CU DI DMWL9CU DMWL9CU DN PF-00614435 DMWL9CU MI TTNDSF4 DMWL9CU MN Proto-oncogene c-Met (MET) DMWL9CU MT DTT DMWL9CU MA Inhibitor DMWL9CU RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1815). DMWL9CU RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1815 DMZ5JNT DI DMZ5JNT DMZ5JNT DN PF-02367982 DMZ5JNT MI TTUV8G9 DMZ5JNT MN Progesterone receptor (PGR) DMZ5JNT MT DTT DMZ5JNT MA Inhibitor DMZ5JNT RN Optimisation of a pyrazole series of progesterone antagonists; Part 1. Bioorg Med Chem Lett. 2010 Jun 1;20(11):3384-6. DMZ5JNT RU https://pubmed.ncbi.nlm.nih.gov/20430618 DMJ0936 DI DMJ0936 DMJ0936 DN PF-03772304 DMJ0936 MI TTHBTOP DMJ0936 MN PI3-kinase gamma (PIK3CG) DMJ0936 MT DTT DMJ0936 MA Inhibitor DMJ0936 RN Discovery of the Highly Potent PI3K/mTOR Dual Inhibitor PF-04979064 through Structure-Based Drug Design. ACS Med Chem Lett. 2012 Nov 7;4(1):91-7. DMJ0936 RU https://pubmed.ncbi.nlm.nih.gov/24900568 DMJ0936 DI DMJ0936 DMJ0936 DN PF-03772304 DMJ0936 MI TTCJG29 DMJ0936 MN Serine/threonine-protein kinase mTOR (mTOR) DMJ0936 MT DTT DMJ0936 MA Inhibitor DMJ0936 RN Discovery of the Highly Potent PI3K/mTOR Dual Inhibitor PF-04979064 through Structure-Based Drug Design. ACS Med Chem Lett. 2012 Nov 7;4(1):91-7. DMJ0936 RU https://pubmed.ncbi.nlm.nih.gov/24900568 DM5NBVG DI DM5NBVG DM5NBVG DN PF-03800130 DM5NBVG MI TTEX248 DM5NBVG MN Dopamine D2 receptor (D2R) DM5NBVG MT DTT DM5NBVG MA Agonist DM5NBVG RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 215). DM5NBVG RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=215 DMMHQL4 DI DMMHQL4 DMMHQL4 DN PF-04475270 DMMHQL4 MI TT79WV3 DMMHQL4 MN Prostaglandin E2 receptor EP4 (PTGER4) DMMHQL4 MT DTT DMMHQL4 MA Agonist DMMHQL4 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 343). DMMHQL4 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=343 DMPEZKT DI DMPEZKT DMPEZKT DN PF-04957325 DMPEZKT MI TTIS4OW DMPEZKT MN Phosphodiesterase 8 (PDE8) DMPEZKT MT DTT DMPEZKT MA Inhibitor DMPEZKT RN Differential Expression and Function of PDE8 and PDE4 in Effector T cells: Implications for PDE8 as a Drug Target in Inflammation.Front Pharmacol. 2016 Aug 23;7:259. DMPEZKT RU https://pubmed.ncbi.nlm.nih.gov/27601994 DMZAE97 DI DMZAE97 DMZAE97 DN PF-05094037 DMZAE97 MI TTCJG29 DMZAE97 MN Serine/threonine-protein kinase mTOR (mTOR) DMZAE97 MT DTT DMZAE97 MA Inhibitor DMZAE97 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2109). DMZAE97 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2109 DMOLI1E DI DMOLI1E DMOLI1E DN PF-05313261 DMOLI1E MI TTKFVXR DMOLI1E MN Renal carcinoma antigen NY-REN-64 (IRAK-4) DMOLI1E MT DTT DMOLI1E MA Inhibitor DMOLI1E RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2045). DMOLI1E RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2045 DMEUT0W DI DMEUT0W DMEUT0W DN PF-06447475 DMEUT0W MI TTK0FEA DMEUT0W MN Leucine-rich repeat kinase 2 (LRRK2) DMEUT0W MT DTT DMEUT0W MA Inhibitor DMEUT0W RN Discovery and preclinical profiling of 3-[4-(morpholin-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl]benzonitrile (PF-06447475), a highly potent, selective, brain penetrant, and in vivo active LRRK2 kinase inhibitor. J Med Chem. 2015 Jan 8;58(1):419-32. DMEUT0W RU https://pubmed.ncbi.nlm.nih.gov/25353650 DMWIVM3 DI DMWIVM3 DMWIVM3 DN PF-06454589 DMWIVM3 MI TTK0FEA DMWIVM3 MN Leucine-rich repeat kinase 2 (LRRK2) DMWIVM3 MT DTT DMWIVM3 MA Inhibitor DMWIVM3 RN Discovery and preclinical profiling of 3-[4-(morpholin-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl]benzonitrile (PF-06447475), a highly potent, selective, brain penetrant, and in vivo active LRRK2 kinase inhibitor. J Med Chem. 2015 Jan 8;58(1):419-32. DMWIVM3 RU https://pubmed.ncbi.nlm.nih.gov/25353650 DMBM7LU DI DMBM7LU DMBM7LU DN PF-0998425 DMBM7LU MI TTKPW01 DMBM7LU MN Androgen receptor messenger RNA (AR mRNA) DMBM7LU MT DTT DMBM7LU MA Inhibitor DMBM7LU RN Rational design and synthesis of 4-((1R,2R)-2-hydroxycyclohexyl)-2(trifluoromethyl)benzonitrile (PF-998425), a novel, nonsteroidal androgen recepto... J Med Chem. 2008 Nov 13;51(21):7010-4. DMBM7LU RU https://pubmed.ncbi.nlm.nih.gov/18921992 DMJMU09 DI DMJMU09 DMJMU09 DN PF-18298 DMJMU09 MI TTVBI8W DMJMU09 MN Dopamine transporter (DAT) DMJMU09 MT DTT DMJMU09 MA Inhibitor DMJMU09 RN Second generation N-(1,2-diphenylethyl)piperazines as dual serotonin and noradrenaline reuptake inhibitors: improving metabolic stability and reduc... Bioorg Med Chem Lett. 2010 Jun 15;20(12):3788-92. DMJMU09 RU https://pubmed.ncbi.nlm.nih.gov/20471260 DMJMU09 DI DMJMU09 DMJMU09 DN PF-18298 DMJMU09 MI TTAWNKZ DMJMU09 MN Norepinephrine transporter (NET) DMJMU09 MT DTT DMJMU09 MA Inhibitor DMJMU09 RN Second generation N-(1,2-diphenylethyl)piperazines as dual serotonin and noradrenaline reuptake inhibitors: improving metabolic stability and reduc... Bioorg Med Chem Lett. 2010 Jun 15;20(12):3788-92. DMJMU09 RU https://pubmed.ncbi.nlm.nih.gov/20471260 DMJMU09 DI DMJMU09 DMJMU09 DN PF-18298 DMJMU09 MI TT3ROYC DMJMU09 MN Serotonin transporter (SERT) DMJMU09 MT DTT DMJMU09 MA Inhibitor DMJMU09 RN Second generation N-(1,2-diphenylethyl)piperazines as dual serotonin and noradrenaline reuptake inhibitors: improving metabolic stability and reduc... Bioorg Med Chem Lett. 2010 Jun 15;20(12):3788-92. DMJMU09 RU https://pubmed.ncbi.nlm.nih.gov/20471260 DM32FKD DI DM32FKD DM32FKD DN PF-228 DM32FKD MI TTH6V3D DM32FKD MN Cyclin-dependent kinase 1 (CDK1) DM32FKD MT DTT DM32FKD MA Inhibitor DM32FKD RN Cellular characterization of a novel focal adhesion kinase inhibitor. J Biol Chem. 2007 May 18;282(20):14845-52. DM32FKD RU https://pubmed.ncbi.nlm.nih.gov/17395594 DM32FKD DI DM32FKD DM32FKD DN PF-228 DM32FKD MI TT7HF4W DM32FKD MN Cyclin-dependent kinase 2 (CDK2) DM32FKD MT DTT DM32FKD MA Inhibitor DM32FKD RN Cellular characterization of a novel focal adhesion kinase inhibitor. J Biol Chem. 2007 May 18;282(20):14845-52. DM32FKD RU https://pubmed.ncbi.nlm.nih.gov/17395594 DM32FKD DI DM32FKD DM32FKD DN PF-228 DM32FKD MI TTQYF7G DM32FKD MN Cyclin-dependent kinase 7 (CDK7) DM32FKD MT DTT DM32FKD MA Inhibitor DM32FKD RN Cellular characterization of a novel focal adhesion kinase inhibitor. J Biol Chem. 2007 May 18;282(20):14845-52. DM32FKD RU https://pubmed.ncbi.nlm.nih.gov/17395594 DM32FKD DI DM32FKD DM32FKD DN PF-228 DM32FKD MI TTON5IT DM32FKD MN Focal adhesion kinase 1 (FAK) DM32FKD MT DTT DM32FKD MA Inhibitor DM32FKD RN Cellular characterization of a novel focal adhesion kinase inhibitor. J Biol Chem. 2007 May 18;282(20):14845-52. DM32FKD RU https://pubmed.ncbi.nlm.nih.gov/17395594 DM32FKD DI DM32FKD DM32FKD DN PF-228 DM32FKD MI TTRSMW9 DM32FKD MN Glycogen synthase kinase-3 beta (GSK-3B) DM32FKD MT DTT DM32FKD MA Inhibitor DM32FKD RN Cellular characterization of a novel focal adhesion kinase inhibitor. J Biol Chem. 2007 May 18;282(20):14845-52. DM32FKD RU https://pubmed.ncbi.nlm.nih.gov/17395594 DM32FKD DI DM32FKD DM32FKD DN PF-228 DM32FKD MI TTJ3E9X DM32FKD MN Inhibitor of nuclear factor kappa-B kinase beta (IKKB) DM32FKD MT DTT DM32FKD MA Inhibitor DM32FKD RN Cellular characterization of a novel focal adhesion kinase inhibitor. J Biol Chem. 2007 May 18;282(20):14845-52. DM32FKD RU https://pubmed.ncbi.nlm.nih.gov/17395594 DMYSWAZ DI DMYSWAZ DMYSWAZ DN PF-271836 DMYSWAZ MI TTSCIUP DMYSWAZ MN Oxytocin receptor (OTR) DMYSWAZ MT DTT DMYSWAZ MA Antagonist DMYSWAZ RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 369). DMYSWAZ RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=369 DMEZA0T DI DMEZA0T DMEZA0T DN PF-3409409 DMEZA0T MI TTVBI8W DMEZA0T MN Dopamine transporter (DAT) DMEZA0T MT DTT DMEZA0T MA Inhibitor DMEZA0T RN Design, synthesis and evaluation of N-[(3S)-pyrrolidin-3-yl]benzamides as selective noradrenaline reuptake inhibitors: CNS penetration in a more po... Bioorg Med Chem Lett. 2009 Aug 15;19(16):4579-83. DMEZA0T RU https://pubmed.ncbi.nlm.nih.gov/19616432 DMEZA0T DI DMEZA0T DMEZA0T DN PF-3409409 DMEZA0T MI TTQ3JTF DMEZA0T MN Muscarinic acetylcholine receptor M4 (CHRM4) DMEZA0T MT DTT DMEZA0T MA Inhibitor DMEZA0T RN Design, synthesis and evaluation of N-[(3S)-pyrrolidin-3-yl]benzamides as selective noradrenaline reuptake inhibitors: CNS penetration in a more po... Bioorg Med Chem Lett. 2009 Aug 15;19(16):4579-83. DMEZA0T RU https://pubmed.ncbi.nlm.nih.gov/19616432 DMEZA0T DI DMEZA0T DMEZA0T DN PF-3409409 DMEZA0T MI TTH18TF DMEZA0T MN Muscarinic acetylcholine receptor M5 (CHRM5) DMEZA0T MT DTT DMEZA0T MA Inhibitor DMEZA0T RN Design, synthesis and evaluation of N-[(3S)-pyrrolidin-3-yl]benzamides as selective noradrenaline reuptake inhibitors: CNS penetration in a more po... Bioorg Med Chem Lett. 2009 Aug 15;19(16):4579-83. DMEZA0T RU https://pubmed.ncbi.nlm.nih.gov/19616432 DMEZA0T DI DMEZA0T DMEZA0T DN PF-3409409 DMEZA0T MI TTAWNKZ DMEZA0T MN Norepinephrine transporter (NET) DMEZA0T MT DTT DMEZA0T MA Inhibitor DMEZA0T RN Design, synthesis and evaluation of N-[(3S)-pyrrolidin-3-yl]benzamides as selective noradrenaline reuptake inhibitors: CNS penetration in a more po... Bioorg Med Chem Lett. 2009 Aug 15;19(16):4579-83. DMEZA0T RU https://pubmed.ncbi.nlm.nih.gov/19616432 DMEZA0T DI DMEZA0T DMEZA0T DN PF-3409409 DMEZA0T MI TT3ROYC DMEZA0T MN Serotonin transporter (SERT) DMEZA0T MT DTT DMEZA0T MA Inhibitor DMEZA0T RN Design, synthesis and evaluation of N-[(3S)-pyrrolidin-3-yl]benzamides as selective noradrenaline reuptake inhibitors: CNS penetration in a more po... Bioorg Med Chem Lett. 2009 Aug 15;19(16):4579-83. DMEZA0T RU https://pubmed.ncbi.nlm.nih.gov/19616432 DM6KVIA DI DM6KVIA DM6KVIA DN PF-3644022 DM6KVIA MI TTMUG9D DM6KVIA MN MAPK-activated protein kinase 2 (MAPKAPK2) DM6KVIA MT DTT DM6KVIA MA Inhibitor DM6KVIA RN A benzothiophene inhibitor of mitogen-activated protein kinase-activated protein kinase 2 inhibits tumor necrosis factor alpha production and has oral anti-inflammatory efficacy in acute and chronic models of inflammation. J Pharmacol Exp Ther. 2010 Jun;333(3):797-807. DM6KVIA RU https://pubmed.ncbi.nlm.nih.gov/20237073 DMCRXAM DI DMCRXAM DMCRXAM DN PF3845 DMCRXAM MI TTDP1UC DMCRXAM MN Fatty acid amide hydrolase (FAAH) DMCRXAM MT DTT DMCRXAM MA Inhibitor DMCRXAM RN Discovery and characterization of a highly selective FAAH inhibitor that reduces inflammatory pain. Chem Biol. 2009 Apr 24;16(4):411-20. DMCRXAM RU https://pubmed.ncbi.nlm.nih.gov/19389627 DM7E391 DI DM7E391 DM7E391 DN PF-3900422 DM7E391 MI TT9JNIC DM7E391 MN Histamine H3 receptor (H3R) DM7E391 MT DTT DM7E391 MA Antagonist DM7E391 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 264). DM7E391 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=264 DMC8G4S DI DMC8G4S DMC8G4S DN PF-4181366 DMC8G4S MI TTZOEBC DMC8G4S MN Phosphodiesterase 9 (PDE9) DMC8G4S MT DTT DMC8G4S MA Inhibitor DMC8G4S RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1309). DMC8G4S RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1309 DMB0OZ3 DI DMB0OZ3 DMB0OZ3 DN PF-429242 DMB0OZ3 MI TTNSM2I DMB0OZ3 MN Endopeptidase S1P (MBTPS1) DMB0OZ3 MT DTT DMB0OZ3 MA Inhibitor DMB0OZ3 RN Aminopyrrolidineamide inhibitors of site-1 protease. Bioorg Med Chem Lett. 2007 Aug 15;17(16):4411-4. DMB0OZ3 RU https://pubmed.ncbi.nlm.nih.gov/17583500 DMMNEJB DI DMMNEJB DMMNEJB DN PF-454583 DMMNEJB MI TTNT7K8 DMMNEJB MN Nociceptin receptor (OPRL1) DMMNEJB MT DTT DMMNEJB MA Antagonist DMMNEJB RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 320). DMMNEJB RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=320 DMI29ED DI DMI29ED DMI29ED DN PF-4840154 DMI29ED MI TTELV3W DMI29ED MN Transformation-sensitive protein p120 (TRPA1) DMI29ED MT DTT DMI29ED MA Activator DMI29ED RN Design and pharmacological evaluation of PF-4840154, a non-electrophilic reference agonist of the TrpA1 channel. Bioorg Med Chem Lett. 2011 Aug 15;21(16):4857-9. DMI29ED RU https://pubmed.ncbi.nlm.nih.gov/21741838 DMV4P7S DI DMV4P7S DMV4P7S DN PF-4957325-00 DMV4P7S MI TTIS4OW DMV4P7S MN Phosphodiesterase 8 (PDE8) DMV4P7S MT DTT DMV4P7S MA Inhibitor DMV4P7S RN PDE8 regulates rapid Teff cell adhesion and proliferation independent of ICER. PLoS One. 2010 Aug 9;5(8):e12011. DMV4P7S RU https://pubmed.ncbi.nlm.nih.gov/20711499 DMSG6F1 DI DMSG6F1 DMSG6F1 DN PF-4989216 DMSG6F1 MI TTHBTOP DMSG6F1 MN PI3-kinase gamma (PIK3CG) DMSG6F1 MT DTT DMSG6F1 MA Inhibitor DMSG6F1 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2155). DMSG6F1 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2155 DMUOFT0 DI DMUOFT0 DMUOFT0 DN PF-5177624 DMUOFT0 MI TT9QBI6 DMUOFT0 MN Phosphoinositide dependent protein kinase-1 (PDPK1) DMUOFT0 MT DTT DMUOFT0 MA Inhibitor DMUOFT0 RN Targeting 3-phosphoinoside-dependent kinase-1 to inhibit insulin-like growth factor-I induced AKT and p70 S6 kinase activation in breast cancer cells. PLoS One. 2012;7(10):e48402. DMUOFT0 RU https://pubmed.ncbi.nlm.nih.gov/23119004 DMD8QOZ DI DMD8QOZ DMD8QOZ DN PF-526014 DMD8QOZ MI TTVBI8W DMD8QOZ MN Dopamine transporter (DAT) DMD8QOZ MT DTT DMD8QOZ MA Inhibitor DMD8QOZ RN Second generation N-(1,2-diphenylethyl)piperazines as dual serotonin and noradrenaline reuptake inhibitors: improving metabolic stability and reduc... Bioorg Med Chem Lett. 2010 Jun 15;20(12):3788-92. DMD8QOZ RU https://pubmed.ncbi.nlm.nih.gov/20471260 DMD8QOZ DI DMD8QOZ DMD8QOZ DN PF-526014 DMD8QOZ MI TTAWNKZ DMD8QOZ MN Norepinephrine transporter (NET) DMD8QOZ MT DTT DMD8QOZ MA Inhibitor DMD8QOZ RN Second generation N-(1,2-diphenylethyl)piperazines as dual serotonin and noradrenaline reuptake inhibitors: improving metabolic stability and reduc... Bioorg Med Chem Lett. 2010 Jun 15;20(12):3788-92. DMD8QOZ RU https://pubmed.ncbi.nlm.nih.gov/20471260 DMD8QOZ DI DMD8QOZ DMD8QOZ DN PF-526014 DMD8QOZ MI TT3ROYC DMD8QOZ MN Serotonin transporter (SERT) DMD8QOZ MT DTT DMD8QOZ MA Inhibitor DMD8QOZ RN Second generation N-(1,2-diphenylethyl)piperazines as dual serotonin and noradrenaline reuptake inhibitors: improving metabolic stability and reduc... Bioorg Med Chem Lett. 2010 Jun 15;20(12):3788-92. DMD8QOZ RU https://pubmed.ncbi.nlm.nih.gov/20471260 DMD8QOZ DI DMD8QOZ DMD8QOZ DN PF-526014 DMD8QOZ MI TTQ6VDM DMD8QOZ MN Voltage-gated potassium channel Kv11.1 (KCNH2) DMD8QOZ MT DTT DMD8QOZ MA Inhibitor DMD8QOZ RN Second generation N-(1,2-diphenylethyl)piperazines as dual serotonin and noradrenaline reuptake inhibitors: improving metabolic stability and reduc... Bioorg Med Chem Lett. 2010 Jun 15;20(12):3788-92. DMD8QOZ RU https://pubmed.ncbi.nlm.nih.gov/20471260 DMC4UHD DI DMC4UHD DMC4UHD DN PF-543 DMC4UHD MI TTOHFIY DMC4UHD MN Sphingosine kinase 1 (SPHK1) DMC4UHD MT DTT DMC4UHD MA Inhibitor DMC4UHD RN Modulation of cellular S1P levels with a novel, potent and specific inhibitor of sphingosine kinase-1. Biochem J. 2012 May 15;444(1):79-88. DMC4UHD RU https://pubmed.ncbi.nlm.nih.gov/22397330 DMY93GJ DI DMY93GJ DMY93GJ DN PF-592379 DMY93GJ MI TT4C8EA DMY93GJ MN Dopamine D3 receptor (D3R) DMY93GJ MT DTT DMY93GJ MA Agonist DMY93GJ RN Lack of abuse potential in a highly selective dopamine D3 agonist, PF-592,379, in drug self-administration and drug discrimination in rats. Behav Pharmacol. 2012 Jun;23(3):280-91. DMY93GJ RU https://pubmed.ncbi.nlm.nih.gov/22470105 DMY93GJ DI DMY93GJ DMY93GJ DN PF-592379 DMY93GJ MI TTE0A2F DMY93GJ MN Dopamine D4 receptor (D4R) DMY93GJ MT DTT DMY93GJ MA Agonist DMY93GJ RN Lack of abuse potential in a highly selective dopamine D3 agonist, PF-592,379, in drug self-administration and drug discrimination in rats. Behav Pharmacol. 2012 Jun;23(3):280-91. DMY93GJ RU https://pubmed.ncbi.nlm.nih.gov/22470105 DMBE24Y DI DMBE24Y DMBE24Y DN PF750 DMBE24Y MI TTDP1UC DMBE24Y MN Fatty acid amide hydrolase (FAAH) DMBE24Y MT DTT DMBE24Y MA Inhibitor DMBE24Y RN Novel mechanistic class of fatty acid amide hydrolase inhibitors with remarkable selectivity. Biochemistry. 2007 Nov 13;46(45):13019-30. DMBE24Y RU https://pubmed.ncbi.nlm.nih.gov/17949010 DM49MYE DI DM49MYE DM49MYE DN PF-877423 DM49MYE MI TTN7BL9 DM49MYE MN Corticosteroid 11-beta-dehydrogenase 1 (HSD11B1) DM49MYE MT DTT DM49MYE MA Inhibitor DM49MYE RN The development and SAR of pyrrolidine carboxamide 11beta-HSD1 inhibitors. Bioorg Med Chem Lett. 2010 May 1;20(9):2897-902. DM49MYE RU https://pubmed.ncbi.nlm.nih.gov/20363126 DMIUZSR DI DMIUZSR DMIUZSR DN PF-956980 DMIUZSR MI TTT7PJU DMIUZSR MN Janus kinase 3 (JAK-3) DMIUZSR MT DTT DMIUZSR MA Inhibitor DMIUZSR RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2049). DMIUZSR RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2049 DM9AZKE DI DM9AZKE DM9AZKE DN PFFFFF DM9AZKE MI TTFPQV7 DM9AZKE MN Galectin-3 (LGALS3) DM9AZKE MT DTT DM9AZKE MA Inhibitor DM9AZKE RN Discovery of galectin ligands in fully randomized combinatorial one-bead-one-compound (glyco)peptide libraries. Bioorg Med Chem Lett. 2007 Feb 1;17(3):793-8. DM9AZKE RU https://pubmed.ncbi.nlm.nih.gov/17095217 DM9CV6S DI DM9CV6S DM9CV6S DN p-F-HHSiD DM9CV6S MI TTOXS3C DM9CV6S MN Muscarinic acetylcholine receptor (CHRM) DM9CV6S MT DTT DM9CV6S MA Antagonist DM9CV6S RN Stimulation of cyclic AMP accumulation and phosphoinositide hydrolysis by M3 muscarinic receptors in the rat peripheral lung. Biochem Pharmacol. 1996 Aug 23;52(4):643-58. DM9CV6S RU https://pubmed.ncbi.nlm.nih.gov/8759038 DM9CV6S DI DM9CV6S DM9CV6S DN p-F-HHSiD DM9CV6S MI TTQ13Z5 DM9CV6S MN Muscarinic acetylcholine receptor M3 (CHRM3) DM9CV6S MT DTT DM9CV6S MA Antagonist DM9CV6S RN Stimulation of cyclic AMP accumulation and phosphoinositide hydrolysis by M3 muscarinic receptors in the rat peripheral lung. Biochem Pharmacol. 1996 Aug 23;52(4):643-58. DM9CV6S RU https://pubmed.ncbi.nlm.nih.gov/8759038 DMVFK3J DI DMVFK3J DMVFK3J DN PFI-1 DMVFK3J MI TTRA6BO DMVFK3J MN Bromodomain-containing protein 4 (BRD4) DMVFK3J MT DTT DMVFK3J MA Inhibitor DMVFK3J RN Identification of a chemical probe for bromo and extra C-terminal bromodomain inhibition through optimization of a fragment-derived hit. J Med Chem. 2012 Nov 26;55(22):9831-7. DMVFK3J RU https://pubmed.ncbi.nlm.nih.gov/23095041 DM619EU DI DM619EU DM619EU DN PFI-3 DM619EU MI TTVQEZS DM619EU MN Mitotic growth and transcription activator (BAF190A) DM619EU MT DTT DM619EU MA Inhibitor DM619EU RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2740). DM619EU RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2740 DM619EU DI DM619EU DM619EU DN PFI-3 DM619EU MI TTH8ZRL DM619EU MN Polybromo-1 (PBRM1) DM619EU MT DTT DM619EU MA Inhibitor DM619EU RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2738). DM619EU RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2738 DMPKXNZ DI DMPKXNZ DMPKXNZ DN PFI-4 DMPKXNZ MI TTT46BN DMPKXNZ MN Bromodomain and PHD finger containing 1 (BRPF1) DMPKXNZ MT DTT DMPKXNZ MA Inhibitor DMPKXNZ RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2730). DMPKXNZ RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2730 DM2TP4Q DI DM2TP4Q DM2TP4Q DN PG-01037 DM2TP4Q MI TTSQIFT DM2TP4Q MN 5-HT 1A receptor (HTR1A) DM2TP4Q MT DTT DM2TP4Q MA Inhibitor DM2TP4Q RN Heterocyclic analogues of N-(4-(4-(2,3-dichlorophenyl)piperazin-1-yl)butyl)arylcarboxamides with functionalized linking chains as novel dopamine D3... J Med Chem. 2007 Aug 23;50(17):4135-46. DM2TP4Q RU https://pubmed.ncbi.nlm.nih.gov/17672446 DM2TP4Q DI DM2TP4Q DM2TP4Q DN PG-01037 DM2TP4Q MI TTJQOD7 DM2TP4Q MN 5-HT 2A receptor (HTR2A) DM2TP4Q MT DTT DM2TP4Q MA Inhibitor DM2TP4Q RN Heterocyclic analogues of N-(4-(4-(2,3-dichlorophenyl)piperazin-1-yl)butyl)arylcarboxamides with functionalized linking chains as novel dopamine D3... J Med Chem. 2007 Aug 23;50(17):4135-46. DM2TP4Q RU https://pubmed.ncbi.nlm.nih.gov/17672446 DM2TP4Q DI DM2TP4Q DM2TP4Q DN PG-01037 DM2TP4Q MI TTWJBZ5 DM2TP4Q MN 5-HT 2C receptor (HTR2C) DM2TP4Q MT DTT DM2TP4Q MA Inhibitor DM2TP4Q RN Heterocyclic analogues of N-(4-(4-(2,3-dichlorophenyl)piperazin-1-yl)butyl)arylcarboxamides with functionalized linking chains as novel dopamine D3... J Med Chem. 2007 Aug 23;50(17):4135-46. DM2TP4Q RU https://pubmed.ncbi.nlm.nih.gov/17672446 DM2TP4Q DI DM2TP4Q DM2TP4Q DN PG-01037 DM2TP4Q MI TTEX248 DM2TP4Q MN Dopamine D2 receptor (D2R) DM2TP4Q MT DTT DM2TP4Q MA Inhibitor DM2TP4Q RN Heterocyclic analogues of N-(4-(4-(2,3-dichlorophenyl)piperazin-1-yl)butyl)arylcarboxamides with functionalized linking chains as novel dopamine D3... J Med Chem. 2007 Aug 23;50(17):4135-46. DM2TP4Q RU https://pubmed.ncbi.nlm.nih.gov/17672446 DM2TP4Q DI DM2TP4Q DM2TP4Q DN PG-01037 DM2TP4Q MI TT4C8EA DM2TP4Q MN Dopamine D3 receptor (D3R) DM2TP4Q MT DTT DM2TP4Q MA Inhibitor DM2TP4Q RN Heterocyclic analogues of N-(4-(4-(2,3-dichlorophenyl)piperazin-1-yl)butyl)arylcarboxamides with functionalized linking chains as novel dopamine D3... J Med Chem. 2007 Aug 23;50(17):4135-46. DM2TP4Q RU https://pubmed.ncbi.nlm.nih.gov/17672446 DM2TP4Q DI DM2TP4Q DM2TP4Q DN PG-01037 DM2TP4Q MI TTE0A2F DM2TP4Q MN Dopamine D4 receptor (D4R) DM2TP4Q MT DTT DM2TP4Q MA Inhibitor DM2TP4Q RN Heterocyclic analogues of N-(4-(4-(2,3-dichlorophenyl)piperazin-1-yl)butyl)arylcarboxamides with functionalized linking chains as novel dopamine D3... J Med Chem. 2007 Aug 23;50(17):4135-46. DM2TP4Q RU https://pubmed.ncbi.nlm.nih.gov/17672446 DMH4AKG DI DMH4AKG DMH4AKG DN PG-1014491 DMH4AKG MI TTIKWV4 DMH4AKG MN Geranyltranstransferase (FDPS) DMH4AKG MT DTT DMH4AKG MA Inhibitor DMH4AKG RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 643). DMH4AKG RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=643 DMWP0BX DI DMWP0BX DMWP0BX DN PG-120 DMWP0BX MI TTN6Y9A DMWP0BX MN CD40L receptor (CD40) DMWP0BX MT DTT DMWP0BX RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1874). DMWP0BX RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1874 DM0NBKR DI DM0NBKR DM0NBKR DN PGC GLP-1 DM0NBKR MI TTVIMDE DM0NBKR MN Glucagon-like peptide 1 receptor (GLP1R) DM0NBKR MT DTT DM0NBKR MA Modulator DM0NBKR RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 249). DM0NBKR RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=249 DMYDW6J DI DMYDW6J DMYDW6J DN PGD2 DMYDW6J MI TTNVEIR DMYDW6J MN Prostaglandin D2 receptor (PTGDR) DMYDW6J MT DTT DMYDW6J MA Agonist DMYDW6J RN A novel biological role for prostaglandin D2 is suggested by distribution studies of the rat DP prostanoid receptor. Eur J Pharmacol. 1999 Jul 14;377(1):101-15. DMYDW6J RU https://pubmed.ncbi.nlm.nih.gov/10448933 DMYDW6J DI DMYDW6J DMYDW6J DN PGD2 DMYDW6J MI TTQDMX5 DMYDW6J MN Prostaglandin D2 receptor 2 (PTGDR2) DMYDW6J MT DTT DMYDW6J MA Agonist DMYDW6J RN CRTH2-specific binding characteristics of [3H]ramatroban and its effects on PGD2-, 15-deoxy-Delta12, 14-PGJ2- and indomethacin-induced agonist resp... Eur J Pharmacol. 2005 Nov 7;524(1-3):30-7. DMYDW6J RU https://pubmed.ncbi.nlm.nih.gov/16256979 DMYDW6J DI DMYDW6J DMYDW6J DN PGD2 DMYDW6J MI TTG1QMU DMYDW6J MN Prostaglandin E2 receptor EP1 (PTGER1) DMYDW6J MT DTT DMYDW6J MA Agonist DMYDW6J RN Cloned human EP1 prostanoid receptor pharmacology characterized using radioligand binding techniques. J Pharm Pharmacol. 2002 Apr;54(4):539-47. DMYDW6J RU https://pubmed.ncbi.nlm.nih.gov/11999132 DMYDW6J DI DMYDW6J DMYDW6J DN PGD2 DMYDW6J MI TT1ZAVI DMYDW6J MN Prostaglandin E2 receptor EP2 (PTGER2) DMYDW6J MT DTT DMYDW6J MA Agonist DMYDW6J RN Importance of the extracellular domain for prostaglandin EP(2) receptor function. Mol Pharmacol. 1999 Sep;56(3):545-51. DMYDW6J RU https://pubmed.ncbi.nlm.nih.gov/10462542 DMYDW6J DI DMYDW6J DMYDW6J DN PGD2 DMYDW6J MI TTPNGDE DMYDW6J MN Prostaglandin E2 receptor EP3 (PTGER3) DMYDW6J MT DTT DMYDW6J MA Agonist DMYDW6J RN Molecular cloning and characterization of the four rat prostaglandin E2 prostanoid receptor subtypes. Eur J Pharmacol. 1997 Dec 11;340(2-3):227-41. DMYDW6J RU https://pubmed.ncbi.nlm.nih.gov/9537820 DMYDW6J DI DMYDW6J DMYDW6J DN PGD2 DMYDW6J MI TT79WV3 DMYDW6J MN Prostaglandin E2 receptor EP4 (PTGER4) DMYDW6J MT DTT DMYDW6J MA Agonist DMYDW6J RN Molecular cloning and characterization of the four rat prostaglandin E2 prostanoid receptor subtypes. Eur J Pharmacol. 1997 Dec 11;340(2-3):227-41. DMYDW6J RU https://pubmed.ncbi.nlm.nih.gov/9537820 DMYDW6J DI DMYDW6J DMYDW6J DN PGD2 DMYDW6J MI TTT2ZAR DMYDW6J MN Prostaglandin F2-alpha receptor (PTGFR) DMYDW6J MT DTT DMYDW6J MA Agonist DMYDW6J RN Ligand binding specificities of the eight types and subtypes of the mouse prostanoid receptors expressed in Chinese hamster ovary cells. Br J Pharmacol. 1997 Sep;122(2):217-24. DMYDW6J RU https://pubmed.ncbi.nlm.nih.gov/9313928 DMWNCLJ DI DMWNCLJ DMWNCLJ DN PGD3 DMWNCLJ MI TTQDMX5 DMWNCLJ MN Prostaglandin D2 receptor 2 (PTGDR2) DMWNCLJ MT DTT DMWNCLJ MA Agonist DMWNCLJ RN Expression and molecular pharmacology of the mouse CRTH2 receptor. J Pharmacol Exp Ther. 2003 Aug;306(2):463-70. DMWNCLJ RU https://pubmed.ncbi.nlm.nih.gov/12721327 DMNY187 DI DMNY187 DMNY187 DN P'-geranyl 2-fluoromevalonate 5-diphosphate DMNY187 MI TTE5J6X DMNY187 MN Diphosphomevalonate decarboxylase (MVD) DMNY187 MT DTT DMNY187 MA Inhibitor DMNY187 RN Human mevalonate diphosphate decarboxylase: characterization, investigation of the mevalonate diphosphate binding site, and crystal structure. Arch Biochem Biophys. 2008 Dec 1;480(1):58-67. DMNY187 RU https://pubmed.ncbi.nlm.nih.gov/18823933 DMJ4SIA DI DMJ4SIA DMJ4SIA DN P'-geranyl 3,5,7-trihydroxy-3-methylheptanate 7-diphosphate DMJ4SIA MI TTE5J6X DMJ4SIA MN Diphosphomevalonate decarboxylase (MVD) DMJ4SIA MT DTT DMJ4SIA MA Inhibitor DMJ4SIA RN Bifunctional inhibitors of mevalonate kinase and mevalonate 5-diphosphate decarboxylase. Org Lett. 2006 Mar 16;8(6):1013-6. DMJ4SIA RU https://pubmed.ncbi.nlm.nih.gov/16524256 DMO9BUR DI DMO9BUR DMO9BUR DN P'-geranyl 3,5,8-trihydroxy-3-methyloctanate 8-diphosphate DMO9BUR MI TTE5J6X DMO9BUR MN Diphosphomevalonate decarboxylase (MVD) DMO9BUR MT DTT DMO9BUR MA Inhibitor DMO9BUR RN Bifunctional inhibitors of mevalonate kinase and mevalonate 5-diphosphate decarboxylase. Org Lett. 2006 Mar 16;8(6):1013-6. DMO9BUR RU https://pubmed.ncbi.nlm.nih.gov/16524256 DM2395E DI DM2395E DM2395E DN P'-geranyl 3,5,9-trihydroxy-3-methylnonanate 9-diphosphate DM2395E MI TTE5J6X DM2395E MN Diphosphomevalonate decarboxylase (MVD) DM2395E MT DTT DM2395E MA Inhibitor DM2395E RN Bifunctional inhibitors of mevalonate kinase and mevalonate 5-diphosphate decarboxylase. Org Lett. 2006 Mar 16;8(6):1013-6. DM2395E RU https://pubmed.ncbi.nlm.nih.gov/16524256 DMUPWQT DI DMUPWQT DMUPWQT DN PGF1alpha DMUPWQT MI TTWOCZI DMUPWQT MN Cation channel sperm-associated protein (CatSper) DMUPWQT MT DTT DMUPWQT MA Activator DMUPWQT RN Progesterone activates the principal Ca2+ channel of human sperm. Nature. 2011 Mar 17;471(7338):387-91. DMUPWQT RU https://pubmed.ncbi.nlm.nih.gov/21412339 DMUPWQT DI DMUPWQT DMUPWQT DN PGF1alpha DMUPWQT MI TT5CISB DMUPWQT MN Cation channel sperm-associated protein 1 (CatSper1) DMUPWQT MT DTT DMUPWQT MA Activator DMUPWQT RN Progesterone activates the principal Ca2+ channel of human sperm. Nature. 2011 Mar 17;471(7338):387-91. DMUPWQT RU https://pubmed.ncbi.nlm.nih.gov/21412339 DMUPWQT DI DMUPWQT DMUPWQT DN PGF1alpha DMUPWQT MI TTOEGC4 DMUPWQT MN Cation channel sperm-associated protein 2 (CatSper2) DMUPWQT MT DTT DMUPWQT MA Activator DMUPWQT RN Progesterone activates the principal Ca2+ channel of human sperm. Nature. 2011 Mar 17;471(7338):387-91. DMUPWQT RU https://pubmed.ncbi.nlm.nih.gov/21412339 DMUPWQT DI DMUPWQT DMUPWQT DN PGF1alpha DMUPWQT MI TTP52ZV DMUPWQT MN Cation channel sperm-associated protein 3 (CatSper3) DMUPWQT MT DTT DMUPWQT MA Activator DMUPWQT RN Progesterone activates the principal Ca2+ channel of human sperm. Nature. 2011 Mar 17;471(7338):387-91. DMUPWQT RU https://pubmed.ncbi.nlm.nih.gov/21412339 DMZFVGC DI DMZFVGC DMZFVGC DN PGH2 DMZFVGC MI TT2O84V DMZFVGC MN Thromboxane A2 receptor (TBXA2R) DMZFVGC MT DTT DMZFVGC MA Agonist DMZFVGC RN Effects of KW-3635, a novel dibenzoxepin derivative of a selective thromboxane A2 antagonist, on human, guinea pig and rat platelets. Jpn J Pharmacol. 1992 Jul;59(3):357-64. DMZFVGC RU https://pubmed.ncbi.nlm.nih.gov/1434130 DMTVY6K DI DMTVY6K DMTVY6K DN PGI-02749 DMTVY6K MI TT9G4N0 DMTVY6K MN Glutamate carboxypeptidase II (GCPII) DMTVY6K MT DTT DMTVY6K MA Inhibitor DMTVY6K RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1606). DMTVY6K RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1606 DMR2LTC DI DMR2LTC DMR2LTC DN PGJ2 DMR2LTC MI TTNVEIR DMR2LTC MN Prostaglandin D2 receptor (PTGDR) DMR2LTC MT DTT DMR2LTC MA Agonist DMR2LTC RN Characterization of the recombinant human prostanoid DP receptor and identification of L-644,698, a novel selective DP agonist. Br J Pharmacol. 1998 Apr;123(7):1317-24. DMR2LTC RU https://pubmed.ncbi.nlm.nih.gov/9579725 DMR2LTC DI DMR2LTC DMR2LTC DN PGJ2 DMR2LTC MI TTQDMX5 DMR2LTC MN Prostaglandin D2 receptor 2 (PTGDR2) DMR2LTC MT DTT DMR2LTC MA Agonist DMR2LTC RN Molecular pharmacology of the human prostaglandin D2 receptor, CRTH2. Br J Pharmacol. 2002 Dec;137(8):1163-72. DMR2LTC RU https://pubmed.ncbi.nlm.nih.gov/12466225 DMLMTIY DI DMLMTIY DMLMTIY DN PGlu-His-Trp-Ser-His-D-Tyr-Leu-Arg-Pro-Gly-NH2 DMLMTIY MI TT8R70G DMLMTIY MN Gonadotropin-releasing hormone receptor (GNRHR) DMLMTIY MT DTT DMLMTIY MA Inhibitor DMLMTIY RN Overlapping, nonidentical binding sites of different classes of nonpeptide antagonists for the human gonadotropin-releasing hormone receptor. J Med Chem. 2006 Jan 26;49(2):637-47. DMLMTIY RU https://pubmed.ncbi.nlm.nih.gov/16420049 DM40PT5 DI DM40PT5 DM40PT5 DN PGlu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2 DM40PT5 MI TT8R70G DM40PT5 MN Gonadotropin-releasing hormone receptor (GNRHR) DM40PT5 MT DTT DM40PT5 MA Inhibitor DM40PT5 RN Overlapping, nonidentical binding sites of different classes of nonpeptide antagonists for the human gonadotropin-releasing hormone receptor. J Med Chem. 2006 Jan 26;49(2):637-47. DM40PT5 RU https://pubmed.ncbi.nlm.nih.gov/16420049 DM5GY6Z DI DM5GY6Z DM5GY6Z DN PH-709829 DM5GY6Z MI TTPC4TU DM5GY6Z MN 5-HT 3A receptor (HTR3A) DM5GY6Z MT DTT DM5GY6Z MA Inhibitor DM5GY6Z RN Discovery of N-[(3R,5R)-1-azabicyclo[3.2.1]oct-3-yl]furo[2,3-c]pyridine-5-carboxamide as an agonist of the alpha7 nicotinic acetylcholine receptor:... Bioorg Med Chem Lett. 2008 Jun 15;18(12):3611-5. DM5GY6Z RU https://pubmed.ncbi.nlm.nih.gov/18490160 DM5GY6Z DI DM5GY6Z DM5GY6Z DN PH-709829 DM5GY6Z MI TTLA931 DM5GY6Z MN Neuronal acetylcholine receptor alpha-7 (CHRNA7) DM5GY6Z MT DTT DM5GY6Z MA Inhibitor DM5GY6Z RN Discovery of N-[(3R,5R)-1-azabicyclo[3.2.1]oct-3-yl]furo[2,3-c]pyridine-5-carboxamide as an agonist of the alpha7 nicotinic acetylcholine receptor:... Bioorg Med Chem Lett. 2008 Jun 15;18(12):3611-5. DM5GY6Z RU https://pubmed.ncbi.nlm.nih.gov/18490160 DMCGX9U DI DMCGX9U DMCGX9U DN PHA-665752 DMCGX9U MI TTNDSF4 DMCGX9U MN Proto-oncogene c-Met (MET) DMCGX9U MT DTT DMCGX9U MA Inhibitor DMCGX9U RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1815). DMCGX9U RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1815 DMHQ6KT DI DMHQ6KT DMHQ6KT DN PHA-666859 DMHQ6KT MI TTQBR95 DMHQ6KT MN Stress-activated protein kinase 2a (p38 alpha) DMHQ6KT MT DTT DMHQ6KT MA Inhibitor DMHQ6KT RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1499). DMHQ6KT RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1499 DMNS70E DI DMNS70E DMNS70E DN PHA-690509 DMNS70E MI TT7HF4W DMNS70E MN Cyclin-dependent kinase 2 (CDK2) DMNS70E MT DTT DMNS70E MA Inhibitor DMNS70E RN Discovery of drug mode of action and drug repositioning from transcriptional responses. Proc Natl Acad Sci U S A. 2010 Aug 17;107(33):14621-6. DMNS70E RU https://pubmed.ncbi.nlm.nih.gov/20679242 DM4H7D5 DI DM4H7D5 DM4H7D5 DN PHA-767491 DM4H7D5 MI TTSMTDI DM4H7D5 MN CDC7-related kinase (CDC7) DM4H7D5 MT DTT DM4H7D5 MA Modulator DM4H7D5 RN Drug design with Cdc7 kinase: a potential novel cancer therapy target. Drug Des Devel Ther. 2009 Feb 6;2:255-64. DM4H7D5 RU https://www.ncbi.nlm.nih.gov/pubmed/19920912 DMALRCH DI DMALRCH DMALRCH DN Phaclofen DMALRCH MI TTDCVZW DMALRCH MN Gamma-aminobutyric acid B receptor (GABBR) DMALRCH MT DTT DMALRCH MA Antagonist DMALRCH RN Astrocytes and interneurons in memory processing in the chick hippocampus: roles for G-coupled protein receptors, GABA(B) and mGluR1. Neurochem Res. 2009 Oct;34(10):1712-20. DMALRCH RU https://pubmed.ncbi.nlm.nih.gov/19415487 DM7H5KY DI DM7H5KY DM7H5KY DN PHASEOLIN DM7H5KY MI TT50QJ3 DM7H5KY MN Influenza Neuraminidase (Influ NA) DM7H5KY MT DTT DM7H5KY MA Inhibitor DM7H5KY RN Prenylated pterocarpans as bacterial neuraminidase inhibitors. Bioorg Med Chem. 2010 May 1;18(9):3335-44. DM7H5KY RU https://pubmed.ncbi.nlm.nih.gov/20363636 DMSQ10I DI DMSQ10I DMSQ10I DN PHASEOLLIDIN DMSQ10I MI TT50QJ3 DMSQ10I MN Influenza Neuraminidase (Influ NA) DMSQ10I MT DTT DMSQ10I MA Inhibitor DMSQ10I RN Prenylated pterocarpans as bacterial neuraminidase inhibitors. Bioorg Med Chem. 2010 May 1;18(9):3335-44. DMSQ10I RU https://pubmed.ncbi.nlm.nih.gov/20363636 DMNJY79 DI DMNJY79 DMNJY79 DN PHCCC DMNJY79 MI TTVBPDM DMNJY79 MN Metabotropic glutamate receptor 1 (mGluR1) DMNJY79 MT DTT DMNJY79 MA Modulator (allosteric modulator) DMNJY79 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 289). DMNJY79 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=289 DMNJY79 DI DMNJY79 DMNJY79 DN PHCCC DMNJY79 MI TTICZ1O DMNJY79 MN Metabotropic glutamate receptor 4 (mGluR4) DMNJY79 MT DTT DMNJY79 MA Modulator (allosteric modulator) DMNJY79 RN (-)-PHCCC, a positive allosteric modulator of mGluR4: characterization, mechanism of action, and neuroprotection. Neuropharmacology. 2003 Dec;45(7):895-906. DMNJY79 RU https://pubmed.ncbi.nlm.nih.gov/14573382 DMNJY79 DI DMNJY79 DMNJY79 DN PHCCC DMNJY79 MI TTWRP2F DMNJY79 MN Metabotropic glutamate receptor 6 (mGluR6) DMNJY79 MT DTT DMNJY79 MA Modulator (allosteric modulator) DMNJY79 RN The mGlu(4) receptor allosteric modulator N-phenyl-7-(hydroxyimino)cyclopropa[b]chromen-1a-carboxamide acts as a direct agonist at mGlu(6) receptors. Eur J Pharmacol. 2008 Jul 28;589(1-3):49-52. DMNJY79 RU https://pubmed.ncbi.nlm.nih.gov/18593581 DMAP04X DI DMAP04X DMAP04X DN PHELLIGRIDIN I DMAP04X MI TTELIN2 DMAP04X MN PTPN1 messenger RNA (PTPN1 mRNA) DMAP04X MT DTT DMAP04X MA Inhibitor DMAP04X RN Structures, biogenesis, and biological activities of pyrano[4,3-c]isochromen-4-one derivatives from the Fungus Phellinus igniarius. J Nat Prod. 2007 Feb;70(2):296-9. DMAP04X RU https://pubmed.ncbi.nlm.nih.gov/17279797 DMJLUFM DI DMJLUFM DMJLUFM DN phenamil DMJLUFM MI TTAHD89 DMJLUFM MN Polycystic kidney disease 2-like 1 (TRPP2) DMJLUFM MT DTT DMJLUFM MA Blocker (channel blocker) DMJLUFM RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 505). DMJLUFM RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=505 DMYT8UG DI DMYT8UG DMYT8UG DN Phenanthrene-2-carboxylic acid hydroxyamide DMYT8UG MI TT2J34L DMYT8UG MN Arachidonate 5-lipoxygenase (5-LOX) DMYT8UG MT DTT DMYT8UG MA Inhibitor DMYT8UG RN Hydroxamic acid inhibitors of 5-lipoxygenase: quantitative structure-activity relationships. J Med Chem. 1990 Mar;33(3):992-8. DMYT8UG RU https://pubmed.ncbi.nlm.nih.gov/2308149 DMRYJBA DI DMRYJBA DMRYJBA DN Phenanthrene-3-carboxylic acid hydroxyamide DMRYJBA MI TT2J34L DMRYJBA MN Arachidonate 5-lipoxygenase (5-LOX) DMRYJBA MT DTT DMRYJBA MA Inhibitor DMRYJBA RN Hydroxamic acid inhibitors of 5-lipoxygenase: quantitative structure-activity relationships. J Med Chem. 1990 Mar;33(3):992-8. DMRYJBA RU https://pubmed.ncbi.nlm.nih.gov/2308149 DMG8KS9 DI DMG8KS9 DMG8KS9 DN Phenanthrene-9,10-dione DMG8KS9 MI TTEB0GD DMG8KS9 MN Cholinesterase (BCHE) DMG8KS9 MT DTT DMG8KS9 MA Inhibitor DMG8KS9 RN Planarity and constraint of the carbonyl groups in 1,2-diones are determinants for selective inhibition of human carboxylesterase 1. J Med Chem. 2007 Nov 15;50(23):5727-34. DMG8KS9 RU https://pubmed.ncbi.nlm.nih.gov/17941623 DMG8KS9 DI DMG8KS9 DMG8KS9 DN Phenanthrene-9,10-dione DMG8KS9 MI TTMF541 DMG8KS9 MN Liver carboxylesterase (CES1) DMG8KS9 MT DTT DMG8KS9 MA Inhibitor DMG8KS9 RN Planarity and constraint of the carbonyl groups in 1,2-diones are determinants for selective inhibition of human carboxylesterase 1. J Med Chem. 2007 Nov 15;50(23):5727-34. DMG8KS9 RU https://pubmed.ncbi.nlm.nih.gov/17941623 DMG8KS9 DI DMG8KS9 DMG8KS9 DN Phenanthrene-9,10-dione DMG8KS9 MI DE9JFMC DMG8KS9 MN NADPH-dependent carbonyl reductase 1 (CBR1) DMG8KS9 MT DME DMG8KS9 MA Metabolism DMG8KS9 RN Studies on reduction of S-nitrosoglutathione by human carbonyl reductases 1 and 3. Chem Biol Interact. 2011 May 30;191(1-3):95-103. DMG8KS9 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=21256830 DMG8KS9 DI DMG8KS9 DMG8KS9 DN Phenanthrene-9,10-dione DMG8KS9 MI DEIVKZ8 DMG8KS9 MN NADPH-dependent carbonyl reductase 3 (CBR3) DMG8KS9 MT DME DMG8KS9 MA Metabolism DMG8KS9 RN Studies on reduction of S-nitrosoglutathione by human carbonyl reductases 1 and 3. Chem Biol Interact. 2011 May 30;191(1-3):95-103. DMG8KS9 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=21256830 DMG8KS9 DI DMG8KS9 DMG8KS9 DN Phenanthrene-9,10-dione DMG8KS9 MI DEP6GT1 DMG8KS9 MN Small intestine reductase (AKR1B10) DMG8KS9 MT DME DMG8KS9 MA Metabolism DMG8KS9 RN Exposure to 9,10-phenanthrenequinone accelerates malignant progression of lung cancer cells through up-regulation of aldo-keto reductase 1B10. Toxicol Appl Pharmacol. 2014 Jul 15;278(2):180-9. DMG8KS9 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=24813866 DMCTVMI DI DMCTVMI DMCTVMI DN PHENAZOCINE DMCTVMI MI TT27RFC DMCTVMI MN Opioid receptor delta (OPRD1) DMCTVMI MT DTT DMCTVMI MA Inhibitor DMCTVMI RN Syntheses and opioid receptor binding properties of carboxamido-substituted opioids. Bioorg Med Chem Lett. 2009 Jan 1;19(1):203-8. DMCTVMI RU https://pubmed.ncbi.nlm.nih.gov/19027293 DMCTVMI DI DMCTVMI DMCTVMI DN PHENAZOCINE DMCTVMI MI TTQW87Y DMCTVMI MN Opioid receptor kappa (OPRK1) DMCTVMI MT DTT DMCTVMI MA Inhibitor DMCTVMI RN Syntheses and opioid receptor binding properties of carboxamido-substituted opioids. Bioorg Med Chem Lett. 2009 Jan 1;19(1):203-8. DMCTVMI RU https://pubmed.ncbi.nlm.nih.gov/19027293 DMCTVMI DI DMCTVMI DMCTVMI DN PHENAZOCINE DMCTVMI MI TTKWM86 DMCTVMI MN Opioid receptor mu (MOP) DMCTVMI MT DTT DMCTVMI MA Inhibitor DMCTVMI RN Syntheses and opioid receptor binding properties of carboxamido-substituted opioids. Bioorg Med Chem Lett. 2009 Jan 1;19(1):203-8. DMCTVMI RU https://pubmed.ncbi.nlm.nih.gov/19027293 DMCE985 DI DMCE985 DMCE985 DN Phenazone DMCE985 MI DEJGDUW DMCE985 MN Cytochrome P450 1A2 (CYP1A2) DMCE985 MT DME DMCE985 MA Metabolism DMCE985 RN Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. DMCE985 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=19515014 DMCE985 DI DMCE985 DMCE985 DN Phenazone DMCE985 MI DEJVYAZ DMCE985 MN Cytochrome P450 2A6 (CYP2A6) DMCE985 MT DME DMCE985 MA Metabolism DMCE985 RN Identification of the human hepatic cytochromes P450 involved in the in vitro oxidation of antipyrine. Drug Metab Dispos. 1996 Apr;24(4):487-94. DMCE985 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=8801065 DMCE985 DI DMCE985 DMCE985 DN Phenazone DMCE985 MI DEPKLMQ DMCE985 MN Cytochrome P450 2B6 (CYP2B6) DMCE985 MT DME DMCE985 MA Metabolism DMCE985 RN Orphenadrine and methimazole inhibit multiple cytochrome P450 enzymes in human liver microsomes. Drug Metab Dispos. 1997 Mar;25(3):390-3. DMCE985 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=9172960 DMCE985 DI DMCE985 DMCE985 DN Phenazone DMCE985 MI DEZMWRE DMCE985 MN Cytochrome P450 2C18 (CYP2C18) DMCE985 MT DME DMCE985 MA Metabolism DMCE985 RN Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. DMCE985 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=19515014 DMCE985 DI DMCE985 DMCE985 DN Phenazone DMCE985 MI DES5XRU DMCE985 MN Cytochrome P450 2C8 (CYP2C8) DMCE985 MT DME DMCE985 MA Metabolism DMCE985 RN Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. DMCE985 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=19515014 DMCE985 DI DMCE985 DMCE985 DN Phenazone DMCE985 MI DE5IED8 DMCE985 MN Cytochrome P450 2C9 (CYP2C9) DMCE985 MT DME DMCE985 MA Metabolism DMCE985 RN Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. DMCE985 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=19515014 DMCE985 DI DMCE985 DMCE985 DN Phenazone DMCE985 MI DECB0K3 DMCE985 MN Cytochrome P450 2D6 (CYP2D6) DMCE985 MT DME DMCE985 MA Metabolism DMCE985 RN Identification of the human hepatic cytochromes P450 involved in the in vitro oxidation of antipyrine. Drug Metab Dispos. 1996 Apr;24(4):487-94. DMCE985 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=8801065 DMCE985 DI DMCE985 DMCE985 DN Phenazone DMCE985 MI DEVDYN7 DMCE985 MN Cytochrome P450 2E1 (CYP2E1) DMCE985 MT DME DMCE985 MA Metabolism DMCE985 RN Identification of the human hepatic cytochromes P450 involved in the in vitro oxidation of antipyrine. Drug Metab Dispos. 1996 Apr;24(4):487-94. DMCE985 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=8801065 DMCE985 DI DMCE985 DMCE985 DN Phenazone DMCE985 MI DE4LYSA DMCE985 MN Cytochrome P450 3A4 (CYP3A4) DMCE985 MT DME DMCE985 MA Metabolism DMCE985 RN Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. DMCE985 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=19515014 DMCE985 DI DMCE985 DMCE985 DN Phenazone DMCE985 MI DEGTFWK DMCE985 MN Mephenytoin 4-hydroxylase (CYP2C19) DMCE985 MT DME DMCE985 MA Metabolism DMCE985 RN Orphenadrine and methimazole inhibit multiple cytochrome P450 enzymes in human liver microsomes. Drug Metab Dispos. 1997 Mar;25(3):390-3. DMCE985 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=9172960 DMCE985 DI DMCE985 DMCE985 DN Phenazone DMCE985 MI TT8NGED DMCE985 MN Prostaglandin G/H synthase 1 (COX-1) DMCE985 MT DTT DMCE985 MA Inhibitor DMCE985 RN Pharmacokinetic and pharmacodynamic aspects of the ideal COX-2 inhibitor: a pharmacologist's perspective. Clin Exp Rheumatol. 2001 Nov-Dec;19(6 Suppl 25):S51-7. DMCE985 RU https://pubmed.ncbi.nlm.nih.gov/11695253 DMCE985 DI DMCE985 DMCE985 DN Phenazone DMCE985 MI DEZV4AP DMCE985 MN RNA cytidine acetyltransferase (hALP) DMCE985 MT DME DMCE985 MA Metabolism DMCE985 RN Evaluation of the influence of diabetes mellitus on antipyrine metabolism and CYP1A2 and CYP2D6 activity. Pharmacotherapy. 2000 Feb;20(2):182-90. DMCE985 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=10678296 DMQBEYX DI DMQBEYX DMQBEYX DN Phencyclidine DMQBEYX MI TTLD29N DMQBEYX MN Glutamate receptor ionotropic NMDA 1 (NMDAR1) DMQBEYX MT DTT DMQBEYX MA Inhibitor DMQBEYX RN Synthesis and biological activity of conformationally restricted analogs of milnacipran: (1S,2R)-1-phenyl-2-[(S)-1-aminopropyl]-N,N-diethylcyclopro... J Med Chem. 1996 Nov 22;39(24):4844-52. DMQBEYX RU https://pubmed.ncbi.nlm.nih.gov/8941398 DMQBEYX DI DMQBEYX DMQBEYX DN Phencyclidine DMQBEYX MI TTKJEMQ DMQBEYX MN Glutamate receptor ionotropic NMDA 2A (NMDAR2A) DMQBEYX MT DTT DMQBEYX MA Inhibitor DMQBEYX RN Synthesis and biological activity of conformationally restricted analogs of milnacipran: (1S,2R)-1-phenyl-2-[(S)-1-aminopropyl]-N,N-diethylcyclopro... J Med Chem. 1996 Nov 22;39(24):4844-52. DMQBEYX RU https://pubmed.ncbi.nlm.nih.gov/8941398 DMQBEYX DI DMQBEYX DMQBEYX DN Phencyclidine DMQBEYX MI TTN9D8E DMQBEYX MN Glutamate receptor ionotropic NMDA 2B (NMDAR2B) DMQBEYX MT DTT DMQBEYX MA Inhibitor DMQBEYX RN Synthesis and biological activity of conformationally restricted analogs of milnacipran: (1S,2R)-1-phenyl-2-[(S)-1-aminopropyl]-N,N-diethylcyclopro... J Med Chem. 1996 Nov 22;39(24):4844-52. DMQBEYX RU https://pubmed.ncbi.nlm.nih.gov/8941398 DMQBEYX DI DMQBEYX DMQBEYX DN Phencyclidine DMQBEYX MI DTT79CX DMQBEYX MN Organic cation transporter 1 (SLC22A1) DMQBEYX MT DTP DMQBEYX MA Substrate DMQBEYX RN Drug transporters of platinum-based anticancer agents and their clinical significance. Drug Resist Updat. 2011 Feb;14(1):22-34. DMQBEYX RU https://doi.org/10.1016/j.drup.2010.12.002 DMQWFO1 DI DMQWFO1 DMQWFO1 DN Phenethyl-(3-phenyl-propyl)-amine DMQWFO1 MI TTLD29N DMQWFO1 MN Glutamate receptor ionotropic NMDA 1 (NMDAR1) DMQWFO1 MT DTT DMQWFO1 MA Inhibitor DMQWFO1 RN Structure-activity relationships for a series of bis(phenylalkyl)amines: potent subtype-selective inhibitors of N-methyl-D-aspartate receptors. J Med Chem. 1998 Aug 27;41(18):3499-506. DMQWFO1 RU https://pubmed.ncbi.nlm.nih.gov/9719603 DMQWFO1 DI DMQWFO1 DMQWFO1 DN Phenethyl-(3-phenyl-propyl)-amine DMQWFO1 MI TTN9D8E DMQWFO1 MN Glutamate receptor ionotropic NMDA 2B (NMDAR2B) DMQWFO1 MT DTT DMQWFO1 MA Inhibitor DMQWFO1 RN Structure-activity relationships for a series of bis(phenylalkyl)amines: potent subtype-selective inhibitors of N-methyl-D-aspartate receptors. J Med Chem. 1998 Aug 27;41(18):3499-506. DMQWFO1 RU https://pubmed.ncbi.nlm.nih.gov/9719603 DMFQMHK DI DMFQMHK DMFQMHK DN Phenethyl-(4-phenyl-butyl)-amine DMFQMHK MI TTLD29N DMFQMHK MN Glutamate receptor ionotropic NMDA 1 (NMDAR1) DMFQMHK MT DTT DMFQMHK MA Inhibitor DMFQMHK RN Structure-activity relationships for a series of bis(phenylalkyl)amines: potent subtype-selective inhibitors of N-methyl-D-aspartate receptors. J Med Chem. 1998 Aug 27;41(18):3499-506. DMFQMHK RU https://pubmed.ncbi.nlm.nih.gov/9719603 DMFQMHK DI DMFQMHK DMFQMHK DN Phenethyl-(4-phenyl-butyl)-amine DMFQMHK MI TTN9D8E DMFQMHK MN Glutamate receptor ionotropic NMDA 2B (NMDAR2B) DMFQMHK MT DTT DMFQMHK MA Inhibitor DMFQMHK RN Structure-activity relationships for a series of bis(phenylalkyl)amines: potent subtype-selective inhibitors of N-methyl-D-aspartate receptors. J Med Chem. 1998 Aug 27;41(18):3499-506. DMFQMHK RU https://pubmed.ncbi.nlm.nih.gov/9719603 DMX0G4F DI DMX0G4F DMX0G4F DN Phenethylamine DMX0G4F MI TTJQOD7 DMX0G4F MN 5-HT 2A receptor (HTR2A) DMX0G4F MT DTT DMX0G4F MA Inhibitor DMX0G4F RN Exploring the relationship between binding modes of 9-(aminomethyl)-9,10-dihydroanthracene and cyproheptadine analogues at the 5-HT2A serotonin rec... Bioorg Med Chem Lett. 2001 Feb 26;11(4):563-6. DMX0G4F RU https://pubmed.ncbi.nlm.nih.gov/11229772 DMX0G4F DI DMX0G4F DMX0G4F DN Phenethylamine DMX0G4F MI DE6SOC5 DMX0G4F MN Copper amine oxidase (AOC3) DMX0G4F MT DME DMX0G4F MA Metabolism DMX0G4F RN The unique substrate specificity of human AOC2, a semicarbazide-sensitive amine oxidase. Cell Mol Life Sci. 2009 Aug;66(16):2743-57. DMX0G4F RU https://www.ncbi.nlm.nih.gov/pubmed/?term=19588076 DMX0G4F DI DMX0G4F DMX0G4F DN Phenethylamine DMX0G4F MI DERE4TU DMX0G4F MN Monoamine oxidase type A (MAO-A) DMX0G4F MT DME DMX0G4F MA Metabolism DMX0G4F RN Do monomeric vs dimeric forms of MAO-A make a difference? A direct comparison of the catalytic properties of rat and human MAO-A's. J Neural Transm (Vienna). 2007;114(6):721-4. DMX0G4F RU https://www.ncbi.nlm.nih.gov/pubmed/?term=17401534 DMX0G4F DI DMX0G4F DMX0G4F DN Phenethylamine DMX0G4F MI DE8DP90 DMX0G4F MN Semicarbazide-sensitive amine oxidase (AOC2) DMX0G4F MT DME DMX0G4F MA Metabolism DMX0G4F RN The unique substrate specificity of human AOC2, a semicarbazide-sensitive amine oxidase. Cell Mol Life Sci. 2009 Aug;66(16):2743-57. DMX0G4F RU https://www.ncbi.nlm.nih.gov/pubmed/?term=19588076 DMPDVG2 DI DMPDVG2 DMPDVG2 DN Phenethylboronic acid DMPDVG2 MI TTHQPL7 DMPDVG2 MN Carbonic anhydrase I (CA-I) DMPDVG2 MT DTT DMPDVG2 MA Inhibitor DMPDVG2 RN Carbonic anhydrase inhibitors. Inhibition of the fungal beta-carbonic anhydrases from Candida albicans and Cryptococcus neoformans with boronic acids. Bioorg Med Chem Lett. 2009 May 15;19(10):2642-5. DMPDVG2 RU https://pubmed.ncbi.nlm.nih.gov/19375309 DMPDVG2 DI DMPDVG2 DMPDVG2 DN Phenethylboronic acid DMPDVG2 MI TTANPDJ DMPDVG2 MN Carbonic anhydrase II (CA-II) DMPDVG2 MT DTT DMPDVG2 MA Inhibitor DMPDVG2 RN Carbonic anhydrase inhibitors. Inhibition of the fungal beta-carbonic anhydrases from Candida albicans and Cryptococcus neoformans with boronic acids. Bioorg Med Chem Lett. 2009 May 15;19(10):2642-5. DMPDVG2 RU https://pubmed.ncbi.nlm.nih.gov/19375309 DMPDVG2 DI DMPDVG2 DMPDVG2 DN Phenethylboronic acid DMPDVG2 MI TTDP1UC DMPDVG2 MN Fatty acid amide hydrolase (FAAH) DMPDVG2 MT DTT DMPDVG2 MA Inhibitor DMPDVG2 RN Discovery of boronic acids as novel and potent inhibitors of fatty acid amide hydrolase. J Med Chem. 2008 Nov 27;51(22):7057-60. DMPDVG2 RU https://pubmed.ncbi.nlm.nih.gov/18983140 DM02PAW DI DM02PAW DM02PAW DN Phenethylcarbamic Acid Biphenyl-3-yl Ester DM02PAW MI TTDP1UC DM02PAW MN Fatty acid amide hydrolase (FAAH) DM02PAW MT DTT DM02PAW MA Inhibitor DM02PAW RN Synthesis and quantitative structure-activity relationship of fatty acid amide hydrolase inhibitors: modulation at the N-portion of biphenyl-3-yl a... J Med Chem. 2008 Jun 26;51(12):3487-98. DM02PAW RU https://pubmed.ncbi.nlm.nih.gov/18507372 DMJD8XN DI DMJD8XN DMJD8XN DN PHENIDONE DMJD8XN MI TT2J34L DMJD8XN MN Arachidonate 5-lipoxygenase (5-LOX) DMJD8XN MT DTT DMJD8XN MA Inhibitor DMJD8XN RN Cylindol A, a novel biphenyl ether with 5-lipoxygenase inhibitory activity, and a related compound from Imperata Cylindrica. J Nat Prod. 1994 Sep;57(9):1290-3. DMJD8XN RU https://pubmed.ncbi.nlm.nih.gov/7798964 DMJD8XN DI DMJD8XN DMJD8XN DN PHENIDONE DMJD8XN MI TT8NGED DMJD8XN MN Prostaglandin G/H synthase 1 (COX-1) DMJD8XN MT DTT DMJD8XN MA Inhibitor DMJD8XN RN Indazolinones, a new series of redox-active 5-lipoxygenase inhibitors with built-in selectivity and oral activity. J Med Chem. 1991 Mar;34(3):1028-36. DMJD8XN RU https://pubmed.ncbi.nlm.nih.gov/1848292 DMJD8XN DI DMJD8XN DMJD8XN DN PHENIDONE DMJD8XN MI TTVKILB DMJD8XN MN Prostaglandin G/H synthase 2 (COX-2) DMJD8XN MT DTT DMJD8XN MA Inhibitor DMJD8XN RN Indazolinones, a new series of redox-active 5-lipoxygenase inhibitors with built-in selectivity and oral activity. J Med Chem. 1991 Mar;34(3):1028-36. DMJD8XN RU https://pubmed.ncbi.nlm.nih.gov/1848292 DMYCHTD DI DMYCHTD DMYCHTD DN PHENMEDIPHAM DMYCHTD MI TTDP1UC DMYCHTD MN Fatty acid amide hydrolase (FAAH) DMYCHTD MT DTT DMYCHTD MA Inhibitor DMYCHTD RN Mining biologically-active molecules for inhibitors of fatty acid amide hydrolase (FAAH): identification of phenmedipham and amperozide as FAAH inh... Bioorg Med Chem Lett. 2009 Dec 1;19(23):6793-6. DMYCHTD RU https://pubmed.ncbi.nlm.nih.gov/19850474 DMCTUAD DI DMCTUAD DMCTUAD DN Phenolsulfonphthalein DMCTUAD MI DTVP67E DMCTUAD MN Organic anion transporter 3 (SLC22A8) DMCTUAD MT DTP DMCTUAD MA Substrate DMCTUAD RN Expression levels of renal organic anion transporters (OATs) and their correlation with anionic drug excretion in patients with renal diseases. Pharm Res. 2004 Jan;21(1):61-7. DMCTUAD RU http://www.ncbi.nlm.nih.gov/pubmed/14984259 DMZJO5V DI DMZJO5V DMZJO5V DN Phenoxyarsonous acid DMZJO5V MI TTHQPL7 DMZJO5V MN Carbonic anhydrase I (CA-I) DMZJO5V MT DTT DMZJO5V MA Inhibitor DMZJO5V RN Carbonic anhydrase inhibitors. Inhibition of the newly isolated murine isozyme XIII with anions. Bioorg Med Chem Lett. 2004 Nov 1;14(21):5435-9. DMZJO5V RU https://pubmed.ncbi.nlm.nih.gov/15454240 DMZJO5V DI DMZJO5V DMZJO5V DN Phenoxyarsonous acid DMZJO5V MI TTANPDJ DMZJO5V MN Carbonic anhydrase II (CA-II) DMZJO5V MT DTT DMZJO5V MA Inhibitor DMZJO5V RN Carbonic anhydrase inhibitors. Inhibition of the newly isolated murine isozyme XIII with anions. Bioorg Med Chem Lett. 2004 Nov 1;14(21):5435-9. DMZJO5V RU https://pubmed.ncbi.nlm.nih.gov/15454240 DMJ5GY7 DI DMJ5GY7 DMJ5GY7 DN PHENSTATIN DMJ5GY7 MI TTML2WA DMJ5GY7 MN Tubulin (TUB) DMJ5GY7 MT DTT DMJ5GY7 MA Inhibitor DMJ5GY7 RN Antineoplastic agents. 465. Structural modification of resveratrol: sodium resverastatin phosphate. J Med Chem. 2002 Jun 6;45(12):2534-42. DMJ5GY7 RU https://pubmed.ncbi.nlm.nih.gov/12036362 DMJ5GY7 DI DMJ5GY7 DMJ5GY7 DN PHENSTATIN DMJ5GY7 MI TTYFKSZ DMJ5GY7 MN Tubulin beta (TUBB) DMJ5GY7 MT DTT DMJ5GY7 MA Inhibitor DMJ5GY7 RN Antineoplastic agents. 465. Structural modification of resveratrol: sodium resverastatin phosphate. J Med Chem. 2002 Jun 6;45(12):2534-42. DMJ5GY7 RU https://pubmed.ncbi.nlm.nih.gov/12036362 DMSNIBO DI DMSNIBO DMSNIBO DN Phenyl 1-(4-butoxyphenyl)propylcarbamate DMSNIBO MI TTDP1UC DMSNIBO MN Fatty acid amide hydrolase (FAAH) DMSNIBO MT DTT DMSNIBO MA Inhibitor DMSNIBO RN Oxime carbamate--discovery of a series of novel FAAH inhibitors. Bioorg Med Chem Lett. 2010 Feb 1;20(3):1272-7. DMSNIBO RU https://pubmed.ncbi.nlm.nih.gov/20036536 DM52H1D DI DM52H1D DM52H1D DN Phenyl 10H-phenothiazine-10-carboxylate DM52H1D MI TTEB0GD DM52H1D MN Cholinesterase (BCHE) DM52H1D MT DTT DM52H1D MA Inhibitor DM52H1D RN Carbamates with differential mechanism of inhibition toward acetylcholinesterase and butyrylcholinesterase. J Med Chem. 2008 Jul 24;51(14):4200-12. DM52H1D RU https://pubmed.ncbi.nlm.nih.gov/18570368 DMHDWTS DI DMHDWTS DMHDWTS DN Phenyl 4-(4,5-dihydro-1H-imidazol-2-yl)benzoate DMHDWTS MI TT3WG5C DMHDWTS MN Monoamine oxidase type A (MAO-A) DMHDWTS MT DTT DMHDWTS MA Inhibitor DMHDWTS RN Ultrasound promoted synthesis of 2-imidazolines in water: a greener approach toward monoamine oxidase inhibitors. Bioorg Med Chem Lett. 2009 Jan 15;19(2):546-9. DMHDWTS RU https://pubmed.ncbi.nlm.nih.gov/19064321 DMHDWTS DI DMHDWTS DMHDWTS DN Phenyl 4-(4,5-dihydro-1H-imidazol-2-yl)benzoate DMHDWTS MI TTGP7BY DMHDWTS MN Monoamine oxidase type B (MAO-B) DMHDWTS MT DTT DMHDWTS MA Inhibitor DMHDWTS RN Ultrasound promoted synthesis of 2-imidazolines in water: a greener approach toward monoamine oxidase inhibitors. Bioorg Med Chem Lett. 2009 Jan 15;19(2):546-9. DMHDWTS RU https://pubmed.ncbi.nlm.nih.gov/19064321 DMZ03DT DI DMZ03DT DMZ03DT DN Phenyl 4-(decyloxy)phenylcarbamate DMZ03DT MI TTDP1UC DMZ03DT MN Fatty acid amide hydrolase (FAAH) DMZ03DT MT DTT DMZ03DT MA Inhibitor DMZ03DT RN Oxime carbamate--discovery of a series of novel FAAH inhibitors. Bioorg Med Chem Lett. 2010 Feb 1;20(3):1272-7. DMZ03DT RU https://pubmed.ncbi.nlm.nih.gov/20036536 DMR1MQE DI DMR1MQE DMR1MQE DN Phenyl 4-(dodecyloxy)phenylcarbamate DMR1MQE MI TTDP1UC DMR1MQE MN Fatty acid amide hydrolase (FAAH) DMR1MQE MT DTT DMR1MQE MA Inhibitor DMR1MQE RN Oxime carbamate--discovery of a series of novel FAAH inhibitors. Bioorg Med Chem Lett. 2010 Feb 1;20(3):1272-7. DMR1MQE RU https://pubmed.ncbi.nlm.nih.gov/20036536 DM9UNLH DI DM9UNLH DM9UNLH DN Phenyl 4-(heptyloxy)phenylcarbamate DM9UNLH MI TTDP1UC DM9UNLH MN Fatty acid amide hydrolase (FAAH) DM9UNLH MT DTT DM9UNLH MA Inhibitor DM9UNLH RN Oxime carbamate--discovery of a series of novel FAAH inhibitors. Bioorg Med Chem Lett. 2010 Feb 1;20(3):1272-7. DM9UNLH RU https://pubmed.ncbi.nlm.nih.gov/20036536 DMZ07H6 DI DMZ07H6 DMZ07H6 DN Phenyl 4-(hexyloxy)phenylcarbamate DMZ07H6 MI TTDP1UC DMZ07H6 MN Fatty acid amide hydrolase (FAAH) DMZ07H6 MT DTT DMZ07H6 MA Inhibitor DMZ07H6 RN Oxime carbamate--discovery of a series of novel FAAH inhibitors. Bioorg Med Chem Lett. 2010 Feb 1;20(3):1272-7. DMZ07H6 RU https://pubmed.ncbi.nlm.nih.gov/20036536 DMULMWK DI DMULMWK DMULMWK DN Phenyl 4-(octyloxy)phenylcarbamate DMULMWK MI TTDP1UC DMULMWK MN Fatty acid amide hydrolase (FAAH) DMULMWK MT DTT DMULMWK MA Inhibitor DMULMWK RN Oxime carbamate--discovery of a series of novel FAAH inhibitors. Bioorg Med Chem Lett. 2010 Feb 1;20(3):1272-7. DMULMWK RU https://pubmed.ncbi.nlm.nih.gov/20036536 DMSZ2CO DI DMSZ2CO DMSZ2CO DN Phenyl 4-(undecyloxy)phenylcarbamate DMSZ2CO MI TTDP1UC DMSZ2CO MN Fatty acid amide hydrolase (FAAH) DMSZ2CO MT DTT DMSZ2CO MA Inhibitor DMSZ2CO RN Oxime carbamate--discovery of a series of novel FAAH inhibitors. Bioorg Med Chem Lett. 2010 Feb 1;20(3):1272-7. DMSZ2CO RU https://pubmed.ncbi.nlm.nih.gov/20036536 DMWN9XU DI DMWN9XU DMWN9XU DN Phenyl 7-methoxy-4-phenylbenzofuran-2-ylcarbamate DMWN9XU MI TTM2AOE DMWN9XU MN Adenosine A2a receptor (ADORA2A) DMWN9XU MT DTT DMWN9XU MA Inhibitor DMWN9XU RN Synthetic studies on selective adenosine A2A receptor antagonists: synthesis and structure-activity relationships of novel benzofuran derivatives. Bioorg Med Chem Lett. 2010 Feb 1;20(3):1090-3. DMWN9XU RU https://pubmed.ncbi.nlm.nih.gov/20034788 DMFZH49 DI DMFZH49 DMFZH49 DN Phenyl Boronic acid DMFZH49 MI TTLP6GN DMFZH49 MN Bacterial DD-carboxypeptidase (Bact vanYB) DMFZH49 MT DTT DMFZH49 MA Inhibitor DMFZH49 RN Synthesis and evaluation of 3-(dihydroxyboryl)benzoic acids as D,D-carboxypeptidase R39 inhibitors. J Med Chem. 2009 Oct 8;52(19):6097-106. DMFZH49 RU https://pubmed.ncbi.nlm.nih.gov/19731939 DMFZH49 DI DMFZH49 DMFZH49 DN Phenyl Boronic acid DMFZH49 MI TTUNARX DMFZH49 MN Carbonic anhydrase (CA) DMFZH49 MT DTT DMFZH49 MA Inhibitor DMFZH49 RN Carbonic anhydrase inhibitors: inhibition of the cytosolic human isozyme VII with anions. Bioorg Med Chem Lett. 2006 Jun 15;16(12):3139-43. DMFZH49 RU https://pubmed.ncbi.nlm.nih.gov/16621537 DMFZH49 DI DMFZH49 DMFZH49 DN Phenyl Boronic acid DMFZH49 MI TTHQPL7 DMFZH49 MN Carbonic anhydrase I (CA-I) DMFZH49 MT DTT DMFZH49 MA Inhibitor DMFZH49 RN Carbonic anhydrase inhibitors. Inhibition of the newly isolated murine isozyme XIII with anions. Bioorg Med Chem Lett. 2004 Nov 1;14(21):5435-9. DMFZH49 RU https://pubmed.ncbi.nlm.nih.gov/15454240 DMFZH49 DI DMFZH49 DMFZH49 DN Phenyl Boronic acid DMFZH49 MI TTANPDJ DMFZH49 MN Carbonic anhydrase II (CA-II) DMFZH49 MT DTT DMFZH49 MA Inhibitor DMFZH49 RN Carbonic anhydrase inhibitors. Inhibition of the newly isolated murine isozyme XIII with anions. Bioorg Med Chem Lett. 2004 Nov 1;14(21):5435-9. DMFZH49 RU https://pubmed.ncbi.nlm.nih.gov/15454240 DMFZH49 DI DMFZH49 DMFZH49 DN Phenyl Boronic acid DMFZH49 MI TTZHA0O DMFZH49 MN Carbonic anhydrase IV (CA-IV) DMFZH49 MT DTT DMFZH49 MA Inhibitor DMFZH49 RN Carbonic anhydrase inhibitors: the membrane-associated isoform XV is highly inhibited by inorganic anions. Bioorg Med Chem Lett. 2009 Feb 15;19(4):1155-8. DMFZH49 RU https://pubmed.ncbi.nlm.nih.gov/19128966 DMFZH49 DI DMFZH49 DMFZH49 DN Phenyl Boronic acid DMFZH49 MI TTDP1UC DMFZH49 MN Fatty acid amide hydrolase (FAAH) DMFZH49 MT DTT DMFZH49 MA Inhibitor DMFZH49 RN Discovery of boronic acids as novel and potent inhibitors of fatty acid amide hydrolase. J Med Chem. 2008 Nov 27;51(22):7057-60. DMFZH49 RU https://pubmed.ncbi.nlm.nih.gov/18983140 DMDV1SN DI DMDV1SN DMDV1SN DN Phenyl(2-(trifluoromethyl)quinolin-4-yl)methanol DMDV1SN MI TTK25J1 DMDV1SN MN Adenosine A1 receptor (ADORA1) DMDV1SN MT DTT DMDV1SN MA Inhibitor DMDV1SN RN Antagonists of the human adenosine A2A receptor. Part 1: Discovery and synthesis of thieno[3,2-d]pyrimidine-4-methanone derivatives. Bioorg Med Chem Lett. 2008 May 1;18(9):2916-9. DMDV1SN RU https://pubmed.ncbi.nlm.nih.gov/18406614 DMDV1SN DI DMDV1SN DMDV1SN DN Phenyl(2-(trifluoromethyl)quinolin-4-yl)methanol DMDV1SN MI TTM2AOE DMDV1SN MN Adenosine A2a receptor (ADORA2A) DMDV1SN MT DTT DMDV1SN MA Inhibitor DMDV1SN RN Antagonists of the human adenosine A2A receptor. Part 1: Discovery and synthesis of thieno[3,2-d]pyrimidine-4-methanone derivatives. Bioorg Med Chem Lett. 2008 May 1;18(9):2916-9. DMDV1SN RU https://pubmed.ncbi.nlm.nih.gov/18406614 DMDCTNU DI DMDCTNU DMDCTNU DN Phenyl-(3-phenyl-1H-indazol-6-yl)-amine DMDCTNU MI TTQBR95 DMDCTNU MN Stress-activated protein kinase 2a (p38 alpha) DMDCTNU MT DTT DMDCTNU MA Inhibitor DMDCTNU RN Design and synthesis of 6-anilinoindazoles as selective inhibitors of c-Jun N-terminal kinase-3. Bioorg Med Chem Lett. 2005 Nov 15;15(22):5095-9. DMDCTNU RU https://pubmed.ncbi.nlm.nih.gov/16140012 DMDCTNU DI DMDCTNU DMDCTNU DN Phenyl-(3-phenyl-1H-indazol-6-yl)-amine DMDCTNU MI TT056SO DMDCTNU MN Stress-activated protein kinase JNK3 (JNK3) DMDCTNU MT DTT DMDCTNU MA Inhibitor DMDCTNU RN Design and synthesis of 6-anilinoindazoles as selective inhibitors of c-Jun N-terminal kinase-3. Bioorg Med Chem Lett. 2005 Nov 15;15(22):5095-9. DMDCTNU RU https://pubmed.ncbi.nlm.nih.gov/16140012 DMR2B4O DI DMR2B4O DMR2B4O DN Phenyl-(5-phenyl-oxazol-2-yl)-amine DMR2B4O MI TTUTJGQ DMR2B4O MN Vascular endothelial growth factor receptor 2 (KDR) DMR2B4O MT DTT DMR2B4O MA Inhibitor DMR2B4O RN Discovery and evaluation of 2-anilino-5-aryloxazoles as a novel class of VEGFR2 kinase inhibitors. J Med Chem. 2005 Mar 10;48(5):1610-9. DMR2B4O RU https://pubmed.ncbi.nlm.nih.gov/15743202 DMR2B4O DI DMR2B4O DMR2B4O DN Phenyl-(5-phenyl-oxazol-2-yl)-amine DMR2B4O MI TTDCBX5 DMR2B4O MN Vascular endothelial growth factor receptor 3 (FLT-4) DMR2B4O MT DTT DMR2B4O MA Inhibitor DMR2B4O RN Discovery and evaluation of 2-anilino-5-aryloxazoles as a novel class of VEGFR2 kinase inhibitors. J Med Chem. 2005 Mar 10;48(5):1610-9. DMR2B4O RU https://pubmed.ncbi.nlm.nih.gov/15743202 DMR2B4O DI DMR2B4O DMR2B4O DN Phenyl-(5-phenyl-oxazol-2-yl)-amine DMR2B4O MI TT1VAUK DMR2B4O MN VEGFR1 messenger RNA (VEGFR1 mRNA) DMR2B4O MT DTT DMR2B4O MA Inhibitor DMR2B4O RN Discovery and evaluation of 2-anilino-5-aryloxazoles as a novel class of VEGFR2 kinase inhibitors. J Med Chem. 2005 Mar 10;48(5):1610-9. DMR2B4O RU https://pubmed.ncbi.nlm.nih.gov/15743202 DMIQ18W DI DMIQ18W DMIQ18W DN Phenyl-(9-phenyl-9H-purin-6-yl)-amine DMIQ18W MI TTK25J1 DMIQ18W MN Adenosine A1 receptor (ADORA1) DMIQ18W MT DTT DMIQ18W MA Inhibitor DMIQ18W RN N6,9-disubstituted adenines: potent, selective antagonists at the A1 adenosine receptor. J Med Chem. 1991 Sep;34(9):2877-82. DMIQ18W RU https://pubmed.ncbi.nlm.nih.gov/1895305 DMWEKBD DI DMWEKBD DMWEKBD DN Phenyl-1,4-bismaleimide DMWEKBD MI TTDP1UC DMWEKBD MN Fatty acid amide hydrolase (FAAH) DMWEKBD MT DTT DMWEKBD MA Inhibitor DMWEKBD RN Synthesis and in vitro evaluation of N-substituted maleimide derivatives as selective monoglyceride lipase inhibitors. J Med Chem. 2009 Dec 10;52(23):7410-20. DMWEKBD RU https://pubmed.ncbi.nlm.nih.gov/19583260 DM5A8KR DI DM5A8KR DM5A8KR DN phenylacetyl-Ala,DTrp-phenthylamide DM5A8KR MI TTHYDUM DM5A8KR MN Bombesin receptor (BS) DM5A8KR MT DTT DM5A8KR MA Agonist DM5A8KR RN Pharmacology of putative selective hBRS-3 receptor agonists for human bombesin receptors (BnR): affinities, potencies and selectivity in multiple native and BnR transfected cells. Peptides. 2010 Aug;31(8):1569-78. DM5A8KR RU https://pubmed.ncbi.nlm.nih.gov/20438784 DM16KSA DI DM16KSA DM16KSA DN Phenylacetyl-Arg-Val-Arg-4-amidinobenzylamide DM16KSA MI TTED9LZ DM16KSA MN Neuroendocrine convertase 1 (PCSK1) DM16KSA MT DTT DM16KSA MA Inhibitor DM16KSA RN Potent inhibitors of furin and furin-like proprotein convertases containing decarboxylated P1 arginine mimetics. J Med Chem. 2010 Feb 11;53(3):1067-75. DM16KSA RU https://pubmed.ncbi.nlm.nih.gov/20038105 DM16KSA DI DM16KSA DM16KSA DN Phenylacetyl-Arg-Val-Arg-4-amidinobenzylamide DM16KSA MI TT46F0P DM16KSA MN Neuroendocrine convertase 2 (PCSK2) DM16KSA MT DTT DM16KSA MA Inhibitor DM16KSA RN Potent inhibitors of furin and furin-like proprotein convertases containing decarboxylated P1 arginine mimetics. J Med Chem. 2010 Feb 11;53(3):1067-75. DM16KSA RU https://pubmed.ncbi.nlm.nih.gov/20038105 DM29EFJ DI DM29EFJ DM29EFJ DN phenylacetylrinvanil DM29EFJ MI TTMI6F5 DM29EFJ MN Transient receptor potential cation channel V1 (TRPV1) DM29EFJ MT DTT DM29EFJ MA Activator DM29EFJ RN Development of the first ultra-potent "capsaicinoid" agonist at transient receptor potential vanilloid type 1 (TRPV1) channels and its therapeutic ... J Pharmacol Exp Ther. 2005 Feb;312(2):561-70. DM29EFJ RU https://pubmed.ncbi.nlm.nih.gov/15356216 DMZNFT2 DI DMZNFT2 DMZNFT2 DN Phenylalanylmethane DMZNFT2 MI TT8VUE0 DMZNFT2 MN Chymase (CYM) DMZNFT2 MT DTT DMZNFT2 MA Inhibitor DMZNFT2 RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMZNFT2 RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMHVW61 DI DMHVW61 DMHVW61 DN PHENYLAMINOIMIDAZO(1,2-ALPHA)PYRIDINE DMHVW61 MI TT7HF4W DMHVW61 MN Cyclin-dependent kinase 2 (CDK2) DMHVW61 MT DTT DMHVW61 MA Inhibitor DMHVW61 RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DMHVW61 RU https://pubmed.ncbi.nlm.nih.gov/10592235 DMFRA1Y DI DMFRA1Y DMFRA1Y DN Phenylarsonic acid DMFRA1Y MI TTUNARX DMFRA1Y MN Carbonic anhydrase (CA) DMFRA1Y MT DTT DMFRA1Y MA Inhibitor DMFRA1Y RN Carbonic anhydrase inhibitors: inhibition of the cytosolic human isozyme VII with anions. Bioorg Med Chem Lett. 2006 Jun 15;16(12):3139-43. DMFRA1Y RU https://pubmed.ncbi.nlm.nih.gov/16621537 DMFRA1Y DI DMFRA1Y DMFRA1Y DN Phenylarsonic acid DMFRA1Y MI TTZHA0O DMFRA1Y MN Carbonic anhydrase IV (CA-IV) DMFRA1Y MT DTT DMFRA1Y MA Inhibitor DMFRA1Y RN Carbonic anhydrase inhibitors: inhibition of the membrane-bound human isozyme IV with anions. Bioorg Med Chem Lett. 2004 Dec 6;14(23):5769-73. DMFRA1Y RU https://pubmed.ncbi.nlm.nih.gov/15501038 DMMNYXK DI DMMNYXK DMMNYXK DN Phenylcarbamic Acid Biphenyl-3-yl Ester DMMNYXK MI TTDP1UC DMMNYXK MN Fatty acid amide hydrolase (FAAH) DMMNYXK MT DTT DMMNYXK MA Inhibitor DMMNYXK RN Synthesis and quantitative structure-activity relationship of fatty acid amide hydrolase inhibitors: modulation at the N-portion of biphenyl-3-yl a... J Med Chem. 2008 Jun 26;51(12):3487-98. DMMNYXK RU https://pubmed.ncbi.nlm.nih.gov/18507372 DME75VC DI DME75VC DME75VC DN PHENYLDIFLUOROMETHANESULFONAMIDE DME75VC MI TTUNARX DME75VC MN Carbonic anhydrase (CA) DME75VC MT DTT DME75VC MA Inhibitor DME75VC RN Carbonic anhydrase inhibitors: inhibition of the human isozymes I, II, VA, and IX with a library of substituted difluoromethanesulfonamides. Bioorg Med Chem Lett. 2005 Dec 1;15(23):5192-6. DME75VC RU https://pubmed.ncbi.nlm.nih.gov/16203142 DME75VC DI DME75VC DME75VC DN PHENYLDIFLUOROMETHANESULFONAMIDE DME75VC MI TTHQPL7 DME75VC MN Carbonic anhydrase I (CA-I) DME75VC MT DTT DME75VC MA Inhibitor DME75VC RN Carbonic anhydrase inhibitors: inhibition of the human isozymes I, II, VA, and IX with a library of substituted difluoromethanesulfonamides. Bioorg Med Chem Lett. 2005 Dec 1;15(23):5192-6. DME75VC RU https://pubmed.ncbi.nlm.nih.gov/16203142 DME75VC DI DME75VC DME75VC DN PHENYLDIFLUOROMETHANESULFONAMIDE DME75VC MI TTANPDJ DME75VC MN Carbonic anhydrase II (CA-II) DME75VC MT DTT DME75VC MA Inhibitor DME75VC RN Carbonic anhydrase inhibitors: inhibition of the human isozymes I, II, VA, and IX with a library of substituted difluoromethanesulfonamides. Bioorg Med Chem Lett. 2005 Dec 1;15(23):5192-6. DME75VC RU https://pubmed.ncbi.nlm.nih.gov/16203142 DME75VC DI DME75VC DME75VC DN PHENYLDIFLUOROMETHANESULFONAMIDE DME75VC MI TT2LVK8 DME75VC MN Carbonic anhydrase IX (CA-IX) DME75VC MT DTT DME75VC MA Inhibitor DME75VC RN Carbonic anhydrase inhibitors: inhibition of the human isozymes I, II, VA, and IX with a library of substituted difluoromethanesulfonamides. Bioorg Med Chem Lett. 2005 Dec 1;15(23):5192-6. DME75VC RU https://pubmed.ncbi.nlm.nih.gov/16203142 DMQD2IA DI DMQD2IA DMQD2IA DN Phenylethanolamine DMQD2IA MI DER8LQ6 DMQD2IA MN Phenylethanolamine N-methyltransferase (PNMT) DMQD2IA MT DME DMQD2IA MA Metabolism DMQD2IA RN Structural, mutagenic, and kinetic analysis of the binding of substrates and inhibitors of human phenylethanolamine N-methyltransferase. J Med Chem. 2005 Nov 17;48(23):7243-52. DMQD2IA RU https://www.ncbi.nlm.nih.gov/pubmed/?term=16279783 DMHT9AR DI DMHT9AR DMHT9AR DN phenylglycine-01 DMHT9AR MI TTRLZHP DMHT9AR MN cAMP-dependent chloride channel (CFTR) DMHT9AR MT DTT DMHT9AR MA Activator DMHT9AR RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 707). DMHT9AR RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=707 DMHW93J DI DMHW93J DMHW93J DN Phenylglyoxal DMHW93J MI DEPOVCH DMHW93J MN Maillard deglycase (PARK7) DMHW93J MT DME DMHW93J MA Metabolism DMHW93J RN Stereospecific mechanism of DJ-1 glyoxalases inferred from their hemithioacetal-containing crystal structures. FEBS J. 2014 Dec;281(24):5447-62. DMHW93J RU https://www.ncbi.nlm.nih.gov/pubmed/?term=25283443 DMJTC2B DI DMJTC2B DMJTC2B DN Phenylmercury DMJTC2B MI TT1O264 DMJTC2B MN Coagulation factor Va (F5) DMJTC2B MT DTT DMJTC2B MA Inhibitor DMJTC2B RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMJTC2B RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMGLDFI DI DMGLDFI DMGLDFI DN PHENYLMETHANESULFONAMIDE DMGLDFI MI TTUNARX DMGLDFI MN Carbonic anhydrase (CA) DMGLDFI MT DTT DMGLDFI MA Inhibitor DMGLDFI RN Carbonic anhydrase inhibitors: inhibition of the human isozymes I, II, VA, and IX with a library of substituted difluoromethanesulfonamides. Bioorg Med Chem Lett. 2005 Dec 1;15(23):5192-6. DMGLDFI RU https://pubmed.ncbi.nlm.nih.gov/16203142 DMGLDFI DI DMGLDFI DMGLDFI DN PHENYLMETHANESULFONAMIDE DMGLDFI MI TTHQPL7 DMGLDFI MN Carbonic anhydrase I (CA-I) DMGLDFI MT DTT DMGLDFI MA Inhibitor DMGLDFI RN Carbonic anhydrase inhibitors: inhibition of the human isozymes I, II, VA, and IX with a library of substituted difluoromethanesulfonamides. Bioorg Med Chem Lett. 2005 Dec 1;15(23):5192-6. DMGLDFI RU https://pubmed.ncbi.nlm.nih.gov/16203142 DMGLDFI DI DMGLDFI DMGLDFI DN PHENYLMETHANESULFONAMIDE DMGLDFI MI TTANPDJ DMGLDFI MN Carbonic anhydrase II (CA-II) DMGLDFI MT DTT DMGLDFI MA Inhibitor DMGLDFI RN Carbonic anhydrase inhibitors: inhibition of the human isozymes I, II, VA, and IX with a library of substituted difluoromethanesulfonamides. Bioorg Med Chem Lett. 2005 Dec 1;15(23):5192-6. DMGLDFI RU https://pubmed.ncbi.nlm.nih.gov/16203142 DMGLDFI DI DMGLDFI DMGLDFI DN PHENYLMETHANESULFONAMIDE DMGLDFI MI TT2LVK8 DMGLDFI MN Carbonic anhydrase IX (CA-IX) DMGLDFI MT DTT DMGLDFI MA Inhibitor DMGLDFI RN Carbonic anhydrase inhibitors: inhibition of the human isozymes I, II, VA, and IX with a library of substituted difluoromethanesulfonamides. Bioorg Med Chem Lett. 2005 Dec 1;15(23):5192-6. DMGLDFI RU https://pubmed.ncbi.nlm.nih.gov/16203142 DMYTS73 DI DMYTS73 DMYTS73 DN Phenyl-N,N-bis(tosylmethyl)methanamine DMYTS73 MI TTX4RTB DMYTS73 MN Melanin-concentrating hormone receptor 1 (MCHR1) DMYTS73 MT DTT DMYTS73 MA Inhibitor DMYTS73 RN Discovery of novel chemotypes to a G-protein-coupled receptor through ligand-steered homology modeling and structure-based virtual screening. J Med Chem. 2008 Feb 14;51(3):581-8. DMYTS73 RU https://pubmed.ncbi.nlm.nih.gov/18198821 DMQ6P13 DI DMQ6P13 DMQ6P13 DN Phenylphosphate DMQ6P13 MI TT6PKBN DMQ6P13 MN Proto-oncogene c-Src (SRC) DMQ6P13 MT DTT DMQ6P13 MA Inhibitor DMQ6P13 RN DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Nucleic Acids Res. 2011 Jan;39(Database issue):D1035-41. DMQ6P13 RU https://pubmed.ncbi.nlm.nih.gov/21059682 DMYMNBL DI DMYMNBL DMYMNBL DN Phenyl-phosphonic acid DMYMNBL MI TTANPDJ DMYMNBL MN Carbonic anhydrase II (CA-II) DMYMNBL MT DTT DMYMNBL MA Inhibitor DMYMNBL RN Carbonic anhydrase inhibitors. Interaction of isozymes I, II, IV, V, and IX with organic phosphates and phosphonates. Bioorg Med Chem Lett. 2005 Mar 15;15(6):1683-6. DMYMNBL RU https://pubmed.ncbi.nlm.nih.gov/15745821 DMYMNBL DI DMYMNBL DMYMNBL DN Phenyl-phosphonic acid DMYMNBL MI TTZHA0O DMYMNBL MN Carbonic anhydrase IV (CA-IV) DMYMNBL MT DTT DMYMNBL MA Inhibitor DMYMNBL RN Carbonic anhydrase inhibitors. Interaction of isozymes I, II, IV, V, and IX with organic phosphates and phosphonates. Bioorg Med Chem Lett. 2005 Mar 15;15(6):1683-6. DMYMNBL RU https://pubmed.ncbi.nlm.nih.gov/15745821 DMWAK1R DI DMWAK1R DMWAK1R DN PHENYLPIPERAZINE DMWAK1R MI TTSQIFT DMWAK1R MN 5-HT 1A receptor (HTR1A) DMWAK1R MT DTT DMWAK1R MA Inhibitor DMWAK1R RN 5-HT1 and 5-HT2 binding characteristics of some quipazine analogues. J Med Chem. 1986 Nov;29(11):2375-80. DMWAK1R RU https://pubmed.ncbi.nlm.nih.gov/3783595 DMWAK1R DI DMWAK1R DMWAK1R DN PHENYLPIPERAZINE DMWAK1R MI TT6MSOK DMWAK1R MN 5-HT 1D receptor (HTR1D) DMWAK1R MT DTT DMWAK1R MA Inhibitor DMWAK1R RN 5-HT1 and 5-HT2 binding characteristics of some quipazine analogues. J Med Chem. 1986 Nov;29(11):2375-80. DMWAK1R RU https://pubmed.ncbi.nlm.nih.gov/3783595 DMWAK1R DI DMWAK1R DMWAK1R DN PHENYLPIPERAZINE DMWAK1R MI TTJQOD7 DMWAK1R MN 5-HT 2A receptor (HTR2A) DMWAK1R MT DTT DMWAK1R MA Inhibitor DMWAK1R RN 5-HT1 and 5-HT2 binding characteristics of some quipazine analogues. J Med Chem. 1986 Nov;29(11):2375-80. DMWAK1R RU https://pubmed.ncbi.nlm.nih.gov/3783595 DMRLFJV DI DMRLFJV DMRLFJV DN PHENYLSULFAMATE DMRLFJV MI TTHQPL7 DMRLFJV MN Carbonic anhydrase I (CA-I) DMRLFJV MT DTT DMRLFJV MA Inhibitor DMRLFJV RN Carbonic anhydrase inhibitors: inhibition of the human isozymes I, II, VA, and IX with a library of substituted difluoromethanesulfonamides. Bioorg Med Chem Lett. 2005 Dec 1;15(23):5192-6. DMRLFJV RU https://pubmed.ncbi.nlm.nih.gov/16203142 DMRLFJV DI DMRLFJV DMRLFJV DN PHENYLSULFAMATE DMRLFJV MI TTANPDJ DMRLFJV MN Carbonic anhydrase II (CA-II) DMRLFJV MT DTT DMRLFJV MA Inhibitor DMRLFJV RN Inhibition of carbonic anhydrase-II by sulfamate and sulfamide groups: an investigation involving direct thermodynamic binding measurements. J Med Chem. 2006 Jun 15;49(12):3496-500. DMRLFJV RU https://pubmed.ncbi.nlm.nih.gov/16759092 DMRLFJV DI DMRLFJV DMRLFJV DN PHENYLSULFAMATE DMRLFJV MI TT2LVK8 DMRLFJV MN Carbonic anhydrase IX (CA-IX) DMRLFJV MT DTT DMRLFJV MA Inhibitor DMRLFJV RN Carbonic anhydrase inhibitors: inhibition of the human isozymes I, II, VA, and IX with a library of substituted difluoromethanesulfonamides. Bioorg Med Chem Lett. 2005 Dec 1;15(23):5192-6. DMRLFJV RU https://pubmed.ncbi.nlm.nih.gov/16203142 DMRTHW1 DI DMRTHW1 DMRTHW1 DN PHENYLSULFAMIDE DMRTHW1 MI TTANPDJ DMRTHW1 MN Carbonic anhydrase II (CA-II) DMRTHW1 MT DTT DMRTHW1 MA Inhibitor DMRTHW1 RN Inhibition of carbonic anhydrase-II by sulfamate and sulfamide groups: an investigation involving direct thermodynamic binding measurements. J Med Chem. 2006 Jun 15;49(12):3496-500. DMRTHW1 RU https://pubmed.ncbi.nlm.nih.gov/16759092 DMM1IAU DI DMM1IAU DMM1IAU DN PHENYLTHIOUREA DMM1IAU MI TTULVH8 DMM1IAU MN Tyrosinase (TYR) DMM1IAU MT DTT DMM1IAU MA Inhibitor DMM1IAU RN Analogues of N-hydroxy-N'-phenylthiourea and N-hydroxy-N'-phenylurea as inhibitors of tyrosinase and melanin formation. Bioorg Med Chem Lett. 2008 Jun 15;18(12):3607-10. DMM1IAU RU https://pubmed.ncbi.nlm.nih.gov/18501598 DM7J0YG DI DM7J0YG DM7J0YG DN Phenyl-Uridine-5'-Diphosphate DM7J0YG MI TTGRHIB DM7J0YG MN UDP-glucose 4-epimerase (GALE) DM7J0YG MT DTT DM7J0YG MA Inhibitor DM7J0YG RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DM7J0YG RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMJMLKA DI DMJMLKA DMJMLKA DN Phe-Pro-Glu DMJMLKA MI TTLD29N DMJMLKA MN Glutamate receptor ionotropic NMDA 1 (NMDAR1) DMJMLKA MT DTT DMJMLKA MA Inhibitor DMJMLKA RN New Gly-Pro-Glu (GPE) analogues: expedite solid-phase synthesis and biological activity. Bioorg Med Chem Lett. 2006 Mar 1;16(5):1392-6. DMJMLKA RU https://pubmed.ncbi.nlm.nih.gov/16321525 DMJMLKA DI DMJMLKA DMJMLKA DN Phe-Pro-Glu DMJMLKA MI TTKJEMQ DMJMLKA MN Glutamate receptor ionotropic NMDA 2A (NMDAR2A) DMJMLKA MT DTT DMJMLKA MA Inhibitor DMJMLKA RN New Gly-Pro-Glu (GPE) analogues: expedite solid-phase synthesis and biological activity. Bioorg Med Chem Lett. 2006 Mar 1;16(5):1392-6. DMJMLKA RU https://pubmed.ncbi.nlm.nih.gov/16321525 DMJMLKA DI DMJMLKA DMJMLKA DN Phe-Pro-Glu DMJMLKA MI TTN9D8E DMJMLKA MN Glutamate receptor ionotropic NMDA 2B (NMDAR2B) DMJMLKA MT DTT DMJMLKA MA Inhibitor DMJMLKA RN New Gly-Pro-Glu (GPE) analogues: expedite solid-phase synthesis and biological activity. Bioorg Med Chem Lett. 2006 Mar 1;16(5):1392-6. DMJMLKA RU https://pubmed.ncbi.nlm.nih.gov/16321525 DMWMBP3 DI DMWMBP3 DMWMBP3 DN PheTQS DMWMBP3 MI TTLA931 DMWMBP3 MN Neuronal acetylcholine receptor alpha-7 (CHRNA7) DMWMBP3 MT DTT DMWMBP3 MA Modulator DMWMBP3 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 468). DMWMBP3 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=468 DMP3MOC DI DMP3MOC DMP3MOC DN Philanthotoxin-343 DMP3MOC MI TTVPQTF DMP3MOC MN Glutamate receptor AMPA 1 (GRIA1) DMP3MOC MT DTT DMP3MOC MA Inhibitor DMP3MOC RN Developing a complete pharmacology for AMPA receptors: a perspective on subtype-selective ligands. Bioorg Med Chem. 2010 Feb 15;18(4):1381-7. DMP3MOC RU https://pubmed.ncbi.nlm.nih.gov/20096591 DM7DWZC DI DM7DWZC DM7DWZC DN PhIP glucuronide DM7DWZC MI DE9EXRN DM7DWZC MN Beta-glucuronidase (uidA) DM7DWZC MT DME DM7DWZC MA Metabolism DM7DWZC RN Gut microbial beta-glucuronidase and glycerol/diol dehydratase activity contribute to dietary heterocyclic amine biotransformation. BMC Microbiol. 2019 May 16;19(1):99. DM7DWZC RU https://pubmed.ncbi.nlm.nih.gov/31096909 DMYA50U DI DMYA50U DMYA50U DN Phloretin DMYA50U MI TTQEI32 DMYA50U MN Aquaporin-9 (AQP9) DMYA50U MT DTT DMYA50U MA Inhibitor DMYA50U RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 696). DMYA50U RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=696 DMYA50U DI DMYA50U DMYA50U DN Phloretin DMYA50U MI TT8XNZ7 DMYA50U MN Chloride channel protein 3 (CLC-3) DMYA50U MT DTT DMYA50U MA Blocker (channel blocker) DMYA50U RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 702). DMYA50U RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=702 DMYA50U DI DMYA50U DMYA50U DN Phloretin DMYA50U MI TT6XAGK DMYA50U MN Solute carrier family 23 member 1 (SLC23A1) DMYA50U MT DTT DMYA50U MA Inhibitor DMYA50U RN A family of mammalian Na+-dependent L-ascorbic acid transporters. Nature. 1999 May 6;399(6731):70-5. DMYA50U RU https://pubmed.ncbi.nlm.nih.gov/10331392 DMYA50U DI DMYA50U DMYA50U DN Phloretin DMYA50U MI DEYGVN4 DMYA50U MN UDP-glucuronosyltransferase 1A1 (UGT1A1) DMYA50U MT DME DMYA50U MA Metabolism DMYA50U RN Differential and special properties of the major human UGT1-encoded gastrointestinal UDP-glucuronosyltransferases enhance potential to control chemical uptake. J Biol Chem. 2004 Jan 9;279(2):1429-41. DMYA50U RU https://www.ncbi.nlm.nih.gov/pubmed/?term=14557274 DMYA50U DI DMYA50U DMYA50U DN Phloretin DMYA50U MI DEZO4N3 DMYA50U MN UDP-glucuronosyltransferase 1A7 (UGT1A7) DMYA50U MT DME DMYA50U MA Metabolism DMYA50U RN Differential and special properties of the major human UGT1-encoded gastrointestinal UDP-glucuronosyltransferases enhance potential to control chemical uptake. J Biol Chem. 2004 Jan 9;279(2):1429-41. DMYA50U RU https://www.ncbi.nlm.nih.gov/pubmed/?term=14557274 DMYA50U DI DMYA50U DMYA50U DN Phloretin DMYA50U MI DE2GB8N DMYA50U MN UDP-glucuronosyltransferase 1A8 (UGT1A8) DMYA50U MT DME DMYA50U MA Metabolism DMYA50U RN Differential and special properties of the major human UGT1-encoded gastrointestinal UDP-glucuronosyltransferases enhance potential to control chemical uptake. J Biol Chem. 2004 Jan 9;279(2):1429-41. DMYA50U RU https://www.ncbi.nlm.nih.gov/pubmed/?term=14557274 DMYA50U DI DMYA50U DMYA50U DN Phloretin DMYA50U MI DE85D2P DMYA50U MN UDP-glucuronosyltransferase 1A9 (UGT1A9) DMYA50U MT DME DMYA50U MA Metabolism DMYA50U RN Differential and special properties of the major human UGT1-encoded gastrointestinal UDP-glucuronosyltransferases enhance potential to control chemical uptake. J Biol Chem. 2004 Jan 9;279(2):1429-41. DMYA50U RU https://www.ncbi.nlm.nih.gov/pubmed/?term=14557274 DMNARGO DI DMNARGO DMNARGO DN Phlorizin DMNARGO MI DTFI42L DMNARGO MN Multidrug resistance-associated protein 2 (ABCC2) DMNARGO MT DTP DMNARGO MA Substrate DMNARGO RN Mammalian drug efflux transporters of the ATP binding cassette (ABC) family in multidrug resistance: A review of the past decade. Cancer Lett. 2016 Jan 1;370(1):153-64. DMNARGO RU http://www.ncbi.nlm.nih.gov/pubmed/26499806 DMNARGO DI DMNARGO DMNARGO DN Phlorizin DMNARGO MI TT2UE56 DMNARGO MN Sodium/glucose cotransporter 1 (SGLT1) DMNARGO MT DTT DMNARGO MA Inhibitor DMNARGO RN J Biol Chem. 1988 Jan 5;263(1):187-92.High affinity phlorizin binding to the LLC-PK1 cells exhibits a sodium:phlorizin stoichiometry of 2:1. DMNARGO RU https://pubmed.ncbi.nlm.nih.gov/3335496 DMO1I6G DI DMO1I6G DMO1I6G DN PHLOROFUCOFUROECKOL A DMO1I6G MI TT8JRS7 DMO1I6G MN Beta-secretase (BACE) DMO1I6G MT DTT DMO1I6G MA Inhibitor DMO1I6G RN Molecular docking studies of phlorotannins from Eisenia bicyclis with BACE1 inhibitory activity. Bioorg Med Chem Lett. 2010 Jun 1;20(11):3211-5. DMO1I6G RU https://pubmed.ncbi.nlm.nih.gov/20462757 DMZWTY7 DI DMZWTY7 DMZWTY7 DN Phorbol 12,13-butyrate DMZWTY7 MI TT9WJ8U DMZWTY7 MN Protein kinase C delta (PRKCD) DMZWTY7 MT DTT DMZWTY7 MA Inhibitor DMZWTY7 RN Conformationally constrained analogues of diacylglycerol (DAG). 28. DAG-dioxolanones reveal a new additional interaction site in the C1b domain of ... J Med Chem. 2007 Jul 26;50(15):3465-81. DMZWTY7 RU https://pubmed.ncbi.nlm.nih.gov/17591763 DM096SC DI DM096SC DM096SC DN Phorbol 12-myristate DM096SC MI TTBZ7OD DM096SC MN Protein kinase C epsilon (PRKCE) DM096SC MT DTT DM096SC MA Activator DM096SC RN Protein kinase epsilon dampens the secretory response of model intestinal epithelia during ischemia. Surgery. 2001 Aug;130(2):310-8. DM096SC RU https://pubmed.ncbi.nlm.nih.gov/11490365 DM2USYW DI DM2USYW DM2USYW DN Phosethanolamine DM2USYW MI DEIRJ6O DM2USYW MN Phospholipase C (plc) DM2USYW MT DME DM2USYW MA Metabolism DM2USYW RN Phospholipase C from Clostridium novyi type A. I. Biochim Biophys Acta. 1975 Oct 21;409(1):75-85. DM2USYW RU https://pubmed.ncbi.nlm.nih.gov/241423 DMMHQYB DI DMMHQYB DMMHQYB DN phosphatidyl (3,5) inositol biphosphate DMMHQYB MI TT9XBVO DMMHQYB MN Mucolipin-1 (TRPML1) DMMHQYB MT DTT DMMHQYB MA Activator DMMHQYB RN PI(3,5)P(2) controls membrane trafficking by direct activation of mucolipin Ca(2+) release channels in the endolysosome. Nat Commun. 2010 Jul 13;1:38. DMMHQYB RU https://pubmed.ncbi.nlm.nih.gov/20802798 DMMHQYB DI DMMHQYB DMMHQYB DN phosphatidyl (3,5) inositol biphosphate DMMHQYB MI TTODQE2 DMMHQYB MN Two pore calcium channel protein 1 (TPC1) DMMHQYB MT DTT DMMHQYB MA Activator DMMHQYB RN The voltage-gated sodium channel TPC1 confers endolysosomal excitability. Nat Chem Biol. 2014 Jun;10(6):463-9. DMMHQYB RU https://pubmed.ncbi.nlm.nih.gov/24776928 DMMHQYB DI DMMHQYB DMMHQYB DN phosphatidyl (3,5) inositol biphosphate DMMHQYB MI TTZWC8B DMMHQYB MN Two pore calcium channel protein 2 (TPC2) DMMHQYB MT DTT DMMHQYB MA Activator DMMHQYB RN TPC proteins are phosphoinositide- activated sodium-selective ion channels in endosomes and lysosomes. Cell. 2012 Oct 12;151(2):372-83. DMMHQYB RU https://pubmed.ncbi.nlm.nih.gov/23063126 DMY2RVX DI DMY2RVX DMY2RVX DN Phosphatidylcholine DMY2RVX MI DELNI4J DMY2RVX MN Lecithin-cholesterol acyltransferase (LCAT) DMY2RVX MT DME DMY2RVX MA Metabolism DMY2RVX RN Characterization of lecithin:cholesterol acyltransferase expressed in a human lung cell line. Protein Expr Purif. 2004 Aug;36(2):157-64. DMY2RVX RU https://www.ncbi.nlm.nih.gov/pubmed/?term=15249036 DMOPYWF DI DMOPYWF DMOPYWF DN Phosphatidylethanolamine DMOPYWF MI DTM4YG0 DMOPYWF MN ATP-binding cassette sub-family A member 4 (ABCA4) DMOPYWF MT DTP DMOPYWF MA Substrate DMOPYWF RN The ATP-binding cassette transporter ABCA4: structural and functional properties and role in retinal disease. Adv Exp Med Biol. 2010;703:105-25. DMOPYWF RU http://www.ncbi.nlm.nih.gov/pubmed/20711710 DMOPYWF DI DMOPYWF DMOPYWF DN Phosphatidylethanolamine DMOPYWF MI DTTQ8WI DMOPYWF MN Probable phospholipid-transporting ATPase VA (ATP10A) DMOPYWF MT DTP DMOPYWF MA Substrate DMOPYWF RN Substrates of P4-ATPases: beyond aminophospholipids (phosphatidylserine and phosphatidylethanolamine). FASEB J. 2019 Mar;33(3):3087-3096. DMOPYWF RU http://www.ncbi.nlm.nih.gov/pubmed/30509129 DM76TSG DI DM76TSG DM76TSG DN Phosphatidylserine DM76TSG MI TT5Z1WV DM76TSG MN Adhesion G protein-coupled receptor B1 (BAI1) DM76TSG MT DTT DM76TSG MA Agonist DM76TSG RN BAI1 is an engulfment receptor for apoptotic cells upstream of the ELMO/Dock180/Rac module. Nature. 2007 Nov 15;450(7168):430-4. DM76TSG RU https://pubmed.ncbi.nlm.nih.gov/17960134 DM76TSG DI DM76TSG DM76TSG DN Phosphatidylserine DM76TSG MI DTI7UX6 DM76TSG MN Breast cancer resistance protein (ABCG2) DM76TSG MT DTP DM76TSG MA Substrate DM76TSG RN ABCG2: a potential marker of stem cells and novel target in stem cell and cancer therapy. Life Sci. 2010 Apr 24;86(17-18):631-7. DM76TSG RU https://doi.org/10.1016/j.lfs.2010.02.012 DMIZLVW DI DMIZLVW DMIZLVW DN Phosphocholine DMIZLVW MI TTWRN6M DMIZLVW MN CRP messenger RNA (CRP mRNA) DMIZLVW MT DTT DMIZLVW MA Inhibitor DMIZLVW RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMIZLVW RU https://pubmed.ncbi.nlm.nih.gov/17139284 DM2D947 DI DM2D947 DM2D947 DN Phosphoenolpyruvate DM2D947 MI TTVNA43 DM2D947 MN Bacterial Deoxy-D-manno-octulosonate 8-phosphate synthase (Bact kdsA) DM2D947 MT DTT DM2D947 MA Inhibitor DM2D947 RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DM2D947 RU https://pubmed.ncbi.nlm.nih.gov/17139284 DM2D947 DI DM2D947 DM2D947 DN Phosphoenolpyruvate DM2D947 MI DEPLH5Z DM2D947 MN Phosphoenolpyruvate carboxykinase (PCK1) DM2D947 MT DME DM2D947 MA Metabolism DM2D947 RN Tyr235 of human cytosolic phosphoenolpyruvate carboxykinase influences catalysis through an anion-quadrupole interaction with phosphoenolpyruvate carboxylate. FEBS J. 2008 Dec;275(23):5810-9. DM2D947 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=19021757 DM2D947 DI DM2D947 DM2D947 DN Phosphoenolpyruvate DM2D947 MI DETH24K DM2D947 MN Red cell/liver pyruvate kinase (PKLR) DM2D947 MT DME DM2D947 MA Metabolism DM2D947 RN Energetic coupling between an oxidizable cysteine and the phosphorylatable N-terminus of human liver pyruvate kinase. Biochemistry. 2013 Jan 22;52(3):466-76. DM2D947 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=23270483 DMAYLNO DI DMAYLNO DMAYLNO DN PHOSPHOGLYCOLOHYDROXAMATE DMAYLNO MI TT1FL6V DMAYLNO MN Plasmodium Fructose-bisphosphate aldolase (Malaria FBA) DMAYLNO MT DTT DMAYLNO MA Inhibitor DMAYLNO RN N-Sulfonyl hydroxamate derivatives as inhibitors of class II fructose-1,6-diphosphate aldolase. Bioorg Med Chem Lett. 2005 Dec 15;15(24):5375-7. DMAYLNO RU https://pubmed.ncbi.nlm.nih.gov/16236509 DM4IRU5 DI DM4IRU5 DM4IRU5 DN Phosphomethylphosphonic Acid Guanylate Ester DM4IRU5 MI TT4W1VJ DM4IRU5 MN Bacterial Celldivision protein FtsZ (Bact ftsZ) DM4IRU5 MT DTT DM4IRU5 MA Inhibitor DM4IRU5 RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DM4IRU5 RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMTFHPI DI DMTFHPI DMTFHPI DN Phosphonothreonine DMTFHPI MI TTPS3C0 DMTFHPI MN Aurora kinase A (AURKA) DMTFHPI MT DTT DMTFHPI MA Inhibitor DMTFHPI RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMTFHPI RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMTFHPI DI DMTFHPI DMTFHPI DN Phosphonothreonine DMTFHPI MI TTQYF7G DMTFHPI MN Cyclin-dependent kinase 7 (CDK7) DMTFHPI MT DTT DMTFHPI MA Inhibitor DMTFHPI RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMTFHPI RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMTFHPI DI DMTFHPI DMTFHPI DN Phosphonothreonine DMTFHPI MI TT4TQBX DMTFHPI MN Extracellular signal-regulated kinase 2 (ERK2) DMTFHPI MT DTT DMTFHPI MA Inhibitor DMTFHPI RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMTFHPI RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMTFHPI DI DMTFHPI DMTFHPI DN Phosphonothreonine DMTFHPI MI TTYT93M DMTFHPI MN MAP kinase p38 (MAPK12) DMTFHPI MT DTT DMTFHPI MA Inhibitor DMTFHPI RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMTFHPI RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMTFHPI DI DMTFHPI DMTFHPI DN Phosphonothreonine DMTFHPI MI TT8QL1J DMTFHPI MN Protein kinase C theta (PRKCQ) DMTFHPI MT DTT DMTFHPI MA Inhibitor DMTFHPI RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMTFHPI RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMTFHPI DI DMTFHPI DMTFHPI DN Phosphonothreonine DMTFHPI MI TTH0KSX DMTFHPI MN Rhodopsin (RHO) DMTFHPI MT DTT DMTFHPI MA Inhibitor DMTFHPI RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMTFHPI RU https://pubmed.ncbi.nlm.nih.gov/17139284 DM09MY1 DI DM09MY1 DM09MY1 DN Phosphonotyrosine DM09MY1 MI TT6PKBN DM09MY1 MN Proto-oncogene c-Src (SRC) DM09MY1 MT DTT DM09MY1 MA Inhibitor DM09MY1 RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DM09MY1 RU https://pubmed.ncbi.nlm.nih.gov/17139284 DM09MY1 DI DM09MY1 DM09MY1 DN Phosphonotyrosine DM09MY1 MI TTX41N9 DM09MY1 MN Tyrosine-protein kinase Kit (KIT) DM09MY1 MT DTT DM09MY1 MA Inhibitor DM09MY1 RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DM09MY1 RU https://pubmed.ncbi.nlm.nih.gov/17139284 DM3VL7G DI DM3VL7G DM3VL7G DN Phosphoramidon DM3VL7G MI TT1BGDH DM3VL7G MN Endothelin-converting enzyme (ECE) DM3VL7G MT DTT DM3VL7G MA Inhibitor DM3VL7G RN In vitro enzymatic processing of radiolabelled big ET-1 in human kidney. Biochem Pharmacol. 1998 Mar 1;55(5):697-701. DM3VL7G RU https://pubmed.ncbi.nlm.nih.gov/9515580 DM3VL7G DI DM3VL7G DM3VL7G DN Phosphoramidon DM3VL7G MI TT5TKPM DM3VL7G MN Neutral endopeptidase (MME) DM3VL7G MT DTT DM3VL7G MA Inhibitor DM3VL7G RN Neprilysin, a novel target for ultraviolet B regulation of melanogenesis via melanocortins. J Invest Dermatol. 2000 Sep;115(3):381-7. DM3VL7G RU https://pubmed.ncbi.nlm.nih.gov/10951272 DMS57HX DI DMS57HX DMS57HX DN Phosphoric acid mono-((E)-dec-4-enyl) ester DMS57HX MI TTQ6S1K DMS57HX MN Lysophosphatidic acid receptor 1 (LPAR1) DMS57HX MT DTT DMS57HX MA Inhibitor DMS57HX RN Synthesis, structure-activity relationships, and biological evaluation of fatty alcohol phosphates as lysophosphatidic acid receptor ligands, activ... J Med Chem. 2005 Jul 28;48(15):4919-30. DMS57HX RU https://pubmed.ncbi.nlm.nih.gov/16033271 DMC873V DI DMC873V DMC873V DN Phosphoric acid mono-((E)-dodec-9-enyl) ester DMC873V MI TTQ6S1K DMC873V MN Lysophosphatidic acid receptor 1 (LPAR1) DMC873V MT DTT DMC873V MA Inhibitor DMC873V RN Synthesis, structure-activity relationships, and biological evaluation of fatty alcohol phosphates as lysophosphatidic acid receptor ligands, activ... J Med Chem. 2005 Jul 28;48(15):4919-30. DMC873V RU https://pubmed.ncbi.nlm.nih.gov/16033271 DMET9ZC DI DMET9ZC DMET9ZC DN Phosphoric acid mono-((E)-tetradec-11-enyl) ester DMET9ZC MI TTQ6S1K DMET9ZC MN Lysophosphatidic acid receptor 1 (LPAR1) DMET9ZC MT DTT DMET9ZC MA Inhibitor DMET9ZC RN Synthesis, structure-activity relationships, and biological evaluation of fatty alcohol phosphates as lysophosphatidic acid receptor ligands, activ... J Med Chem. 2005 Jul 28;48(15):4919-30. DMET9ZC RU https://pubmed.ncbi.nlm.nih.gov/16033271 DME8APC DI DME8APC DME8APC DN Phosphoric acid mono-((E)-tetradec-9-enyl) ester DME8APC MI TTQ6S1K DME8APC MN Lysophosphatidic acid receptor 1 (LPAR1) DME8APC MT DTT DME8APC MA Inhibitor DME8APC RN Synthesis, structure-activity relationships, and biological evaluation of fatty alcohol phosphates as lysophosphatidic acid receptor ligands, activ... J Med Chem. 2005 Jul 28;48(15):4919-30. DME8APC RU https://pubmed.ncbi.nlm.nih.gov/16033271 DMANVJY DI DMANVJY DMANVJY DN Phosphoric acid monodec-9-enyl ester DMANVJY MI TTQ6S1K DMANVJY MN Lysophosphatidic acid receptor 1 (LPAR1) DMANVJY MT DTT DMANVJY MA Inhibitor DMANVJY RN Synthesis, structure-activity relationships, and biological evaluation of fatty alcohol phosphates as lysophosphatidic acid receptor ligands, activ... J Med Chem. 2005 Jul 28;48(15):4919-30. DMANVJY RU https://pubmed.ncbi.nlm.nih.gov/16033271 DMME0VN DI DMME0VN DMME0VN DN Phosphoric acid monododecyl ester DMME0VN MI TTQ6S1K DMME0VN MN Lysophosphatidic acid receptor 1 (LPAR1) DMME0VN MT DTT DMME0VN MA Inhibitor DMME0VN RN Synthesis, structure-activity relationships, and biological evaluation of fatty alcohol phosphates as lysophosphatidic acid receptor ligands, activ... J Med Chem. 2005 Jul 28;48(15):4919-30. DMME0VN RU https://pubmed.ncbi.nlm.nih.gov/16033271 DMG5MJL DI DMG5MJL DMG5MJL DN Phosphoric acid monotetradecyl ester DMG5MJL MI TTQ6S1K DMG5MJL MN Lysophosphatidic acid receptor 1 (LPAR1) DMG5MJL MT DTT DMG5MJL MA Inhibitor DMG5MJL RN Synthesis, structure-activity relationships, and biological evaluation of fatty alcohol phosphates as lysophosphatidic acid receptor ligands, activ... J Med Chem. 2005 Jul 28;48(15):4919-30. DMG5MJL RU https://pubmed.ncbi.nlm.nih.gov/16033271 DMN0D14 DI DMN0D14 DMN0D14 DN PhSO2-Gly-(Me-Gly)-Arg-(2-thiazole) DMN0D14 MI TTCIHJA DMN0D14 MN Coagulation factor Xa (F10) DMN0D14 MT DTT DMN0D14 MA Inhibitor DMN0D14 RN Inhibitors of proteases and amide hydrolases that employ an alpha-ketoheterocycle as a key enabling functionality. Bioorg Med Chem. 2008 Feb 15;16(4):1562-95. DMN0D14 RU https://pubmed.ncbi.nlm.nih.gov/18053726 DMI96Y3 DI DMI96Y3 DMI96Y3 DN PHT-427 DMI96Y3 MI TT9QBI6 DMI96Y3 MN Phosphoinositide dependent protein kinase-1 (PDPK1) DMI96Y3 MT DTT DMI96Y3 MA Inhibitor DMI96Y3 RN Molecular pharmacology and antitumor activity of PHT-427, a novel Akt/phosphatidylinositide-dependent protein kinase 1 pleckstrin homology domain inhibitor. Mol Cancer Ther. 2010 Mar;9(3):706-17. DMI96Y3 RU https://pubmed.ncbi.nlm.nih.gov/20197390 DMI96Y3 DI DMI96Y3 DMI96Y3 DN PHT-427 DMI96Y3 MI TTH24WI DMI96Y3 MN RAC-beta serine/threonine-protein kinase (AKT2) DMI96Y3 MT DTT DMI96Y3 MA Inhibitor DMI96Y3 RN Molecular pharmacology and antitumor activity of PHT-427, a novel Akt/phosphatidylinositide-dependent protein kinase 1 pleckstrin homology domain inhibitor. Mol Cancer Ther. 2010 Mar;9(3):706-17. DMI96Y3 RU https://pubmed.ncbi.nlm.nih.gov/20197390 DMF9T64 DI DMF9T64 DMF9T64 DN Phthalic Acid DMF9T64 MI TTH29K0 DMF9T64 MN Mycobacterium Nicotinate-nucleotide pyrophosphorylase (MycB nadC) DMF9T64 MT DTT DMF9T64 MA Inhibitor DMF9T64 RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMF9T64 RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMBHKAV DI DMBHKAV DMBHKAV DN PHTPP DMBHKAV MI TTOM3J0 DMBHKAV MN Estrogen receptor beta (ESR2) DMBHKAV MT DTT DMBHKAV MA Antagonist DMBHKAV RN Structure-guided optimization of estrogen receptor binding affinity and antagonist potency of pyrazolopyrimidines with basic side chains. J Med Chem. 2007 Jan 25;50(2):399-403. DMBHKAV RU https://pubmed.ncbi.nlm.nih.gov/17228884 DMPS1Y2 DI DMPS1Y2 DMPS1Y2 DN P-hydroxyphenethyl trans-ferulate DMPS1Y2 MI TTO9X1H DMPS1Y2 MN 5-HT 7 receptor (HTR7) DMPS1Y2 MT DTT DMPS1Y2 MA Inhibitor DMPS1Y2 RN Serotonergic activity-guided phytochemical investigation of the roots of Angelica sinensis. J Nat Prod. 2006 Apr;69(4):536-41. DMPS1Y2 RU https://pubmed.ncbi.nlm.nih.gov/16643021 DMU30IO DI DMU30IO DMU30IO DN Phylomers DMU30IO MI TT0K6EO DMU30IO MN Stress-activated protein kinase JNK1 (JNK1) DMU30IO MT DTT DMU30IO MA Inhibitor DMU30IO RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1496). DMU30IO RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1496 DM09T76 DI DM09T76 DM09T76 DN physalaemin DM09T76 MI TTZPO1L DM09T76 MN Substance-P receptor (TACR1) DM09T76 MT DTT DM09T76 MA Agonist DM09T76 RN The unpredicted high affinities of a large number of naturally occurring tachykinins for chimeric NK1/NK3 receptors suggest a role for an inhibitory domain in determining receptor specificity. J BiolChem. 1996 Aug 23;271(34):20250-7. DM09T76 RU https://pubmed.ncbi.nlm.nih.gov/8702757 DMSZ1RB DI DMSZ1RB DMSZ1RB DN Phytanic acid DMSZ1RB MI DE87ZNW DMSZ1RB MN Cytochrome P450 121A1 (cyp121) DMSZ1RB MT DME DMSZ1RB MA Metabolism DMSZ1RB RN Function, essentiality, and expression of cytochrome P450 enzymes and their cognate redox partners in Mycobacterium tuberculosis: are they drug targets? Appl Microbiol Biotechnol. 2019 May;103(9):3597-3614. DMSZ1RB RU https://pubmed.ncbi.nlm.nih.gov/30810776 DMSZ1RB DI DMSZ1RB DMSZ1RB DN Phytanic acid DMSZ1RB MI TT6PEUO DMSZ1RB MN Retinoic acid receptor RXR-alpha (RXRA) DMSZ1RB MT DTT DMSZ1RB MA Agonist DMSZ1RB RN Phytanic acid is a retinoid X receptor ligand. Eur J Biochem. 1996 Feb 15;236(1):328-33. DMSZ1RB RU https://pubmed.ncbi.nlm.nih.gov/8617282 DMWJCST DI DMWJCST DMWJCST DN phytosphingosine 1-phosphate DMWJCST MI TTZ8C5Q DMWJCST MN Sphingosine-1-phosphate receptor 4 (S1PR4) DMWJCST MT DTT DMWJCST MA Agonist DMWJCST RN Phytosphingosine 1-phosphate: a high affinity ligand for the S1P(4)/Edg-6 receptor. Biochem Biophys Res Commun. 2002 Sep 27;297(3):600-6. DMWJCST RU https://pubmed.ncbi.nlm.nih.gov/12270137 DM68JNY DI DM68JNY DM68JNY DN PI1 DM68JNY MI TTV1C0Z DM68JNY MN Neuropeptide S receptor (NPSR) DM68JNY MT DTT DM68JNY MA Antagonist DM68JNY RN Tricyclic imidazole antagonists of the Neuropeptide S Receptor. Bioorg Med Chem Lett. 2010 Aug 1;20(15):4704-8. DM68JNY RU https://pubmed.ncbi.nlm.nih.gov/20615693 DMEK4TJ DI DMEK4TJ DMEK4TJ DN PI-103 DMEK4TJ MI TTHBTOP DMEK4TJ MN PI3-kinase gamma (PIK3CG) DMEK4TJ MT DTT DMEK4TJ MA Inhibitor DMEK4TJ RN The PI3K/Akt pathway as a target in the treatment of hematologic malignancies. Anticancer Agents Med Chem. 2009 Jun;9(5):550-9. DMEK4TJ RU https://pubmed.ncbi.nlm.nih.gov/19519296 DMCQUWI DI DMCQUWI DMCQUWI DN PI-3065 DMCQUWI MI TTTHBCA DMCQUWI MN PI3-kinase beta (PIK3CB) DMCQUWI MT DTT DMCQUWI MA Inhibitor DMCQUWI RN Inactivation of PI(3)K p110delta breaks regulatory T-cell-mediated immune tolerance to cancer. Nature. 2014 Jun 19;510(7505):407-11. DMCQUWI RU https://pubmed.ncbi.nlm.nih.gov/24919154 DMCQUWI DI DMCQUWI DMCQUWI DN PI-3065 DMCQUWI MI TTHBTOP DMCQUWI MN PI3-kinase gamma (PIK3CG) DMCQUWI MT DTT DMCQUWI MA Inhibitor DMCQUWI RN Inactivation of PI(3)K p110delta breaks regulatory T-cell-mediated immune tolerance to cancer. Nature. 2014 Jun 19;510(7505):407-11. DMCQUWI RU https://pubmed.ncbi.nlm.nih.gov/24919154 DMQBAM6 DI DMQBAM6 DMQBAM6 DN PIBTU DMQBAM6 MI TTF10I9 DMQBAM6 MN Nitric-oxide synthase inducible (NOS2) DMQBAM6 MT DTT DMQBAM6 MA Inhibitor DMQBAM6 RN Potent and selective inhibition of human nitric oxide synthases. Inhibition by non-amino acid isothioureas. J Biol Chem. 1994 Oct 28;269(43):26669-76. DMQBAM6 RU https://pubmed.ncbi.nlm.nih.gov/7523409 DMYOP45 DI DMYOP45 DMYOP45 DN Piceatannol DMYOP45 MI TTYR7OH DMYOP45 MN Interferon regulatory factor 3 (IRF3) DMYOP45 MT DTT DMYOP45 MA Inhibitor DMYOP45 RN Inhibition of lipopolysaccharide-induced interferon regulatory factor 3 activation and protection from septic shock by hydroxystilbenes. Shock. 2004 May;21(5):470-5. DMYOP45 RU https://pubmed.ncbi.nlm.nih.gov/15087825 DMND2QG DI DMND2QG DMND2QG DN PICROTIN DMND2QG MI TTZ8EM9 DMND2QG MN Glycine receptor (GlyR) DMND2QG MT DTT DMND2QG MA Inhibitor DMND2QG RN Mechanisms for picrotoxinin and picrotin blocks of alpha2 homomeric glycine receptors. J Biol Chem. 2007 Jun 1;282(22):16016-35. DMND2QG RU https://pubmed.ncbi.nlm.nih.gov/17405877 DM9BQTX DI DM9BQTX DM9BQTX DN PIK-75 DM9BQTX MI TTK3PY9 DM9BQTX MN DNA-dependent protein kinase catalytic (PRKDC) DM9BQTX MT DTT DM9BQTX MA Inhibitor DM9BQTX RN A pharmacological map of the PI3-K family defines a role for p110alpha in insulin signaling. Cell. 2006 May 19;125(4):733-47. DM9BQTX RU https://pubmed.ncbi.nlm.nih.gov/16647110 DM9BQTX DI DM9BQTX DM9BQTX DN PIK-75 DM9BQTX MI TTTHBCA DM9BQTX MN PI3-kinase beta (PIK3CB) DM9BQTX MT DTT DM9BQTX MA Inhibitor DM9BQTX RN Synthesis and biological evaluation of sulfonylhydrazone-substituted imidazo[1,2-a]pyridines as novel PI3 kinase p110alpha inhibitors. Bioorg Med Chem. 2007 Sep 1;15(17):5837-44. DM9BQTX RU https://pubmed.ncbi.nlm.nih.gov/17601739 DM9BQTX DI DM9BQTX DM9BQTX DN PIK-75 DM9BQTX MI TTHBTOP DM9BQTX MN PI3-kinase gamma (PIK3CG) DM9BQTX MT DTT DM9BQTX MA Inhibitor DM9BQTX RN Synthesis and biological evaluation of sulfonylhydrazone-substituted imidazo[1,2-a]pyridines as novel PI3 kinase p110alpha inhibitors. Bioorg Med Chem. 2007 Sep 1;15(17):5837-44. DM9BQTX RU https://pubmed.ncbi.nlm.nih.gov/17601739 DM3JBLK DI DM3JBLK DM3JBLK DN PIK-93 DM3JBLK MI TTNPL3B DM3JBLK MN Phosphatidylinositol-4-kinase beta (PI4KB) DM3JBLK MT DTT DM3JBLK MA Inhibitor DM3JBLK RN A pharmacological map of the PI3-K family defines a role for p110alpha in insulin signaling. Cell. 2006 May 19;125(4):733-47. DM3JBLK RU https://pubmed.ncbi.nlm.nih.gov/16647110 DMBERSG DI DMBERSG DMBERSG DN Pim[-Trp-Arg-Nva-Arg-Tyr-NH2]2 DMBERSG MI TTRK9JT DMBERSG MN Neuropeptide Y receptor type 1 (NPY1R) DMBERSG MT DTT DMBERSG MA Inhibitor DMBERSG RN Neuropeptide Y (NPY) Y4 receptor selective agonists based on NPY(32-36): development of an anorectic Y4 receptor selective agonist with picomolar a... J Med Chem. 2006 Apr 20;49(8):2661-5. DMBERSG RU https://pubmed.ncbi.nlm.nih.gov/16610810 DMBERSG DI DMBERSG DMBERSG DN Pim[-Trp-Arg-Nva-Arg-Tyr-NH2]2 DMBERSG MI TTJ6WK9 DMBERSG MN Neuropeptide Y receptor type 2 (NPY2R) DMBERSG MT DTT DMBERSG MA Inhibitor DMBERSG RN Neuropeptide Y (NPY) Y4 receptor selective agonists based on NPY(32-36): development of an anorectic Y4 receptor selective agonist with picomolar a... J Med Chem. 2006 Apr 20;49(8):2661-5. DMBERSG RU https://pubmed.ncbi.nlm.nih.gov/16610810 DMBERSG DI DMBERSG DMBERSG DN Pim[-Trp-Arg-Nva-Arg-Tyr-NH2]2 DMBERSG MI TTW4N16 DMBERSG MN Neuropeptide Y receptor type 4 (NPY4R) DMBERSG MT DTT DMBERSG MA Inhibitor DMBERSG RN Neuropeptide Y (NPY) Y4 receptor selective agonists based on NPY(32-36): development of an anorectic Y4 receptor selective agonist with picomolar a... J Med Chem. 2006 Apr 20;49(8):2661-5. DMBERSG RU https://pubmed.ncbi.nlm.nih.gov/16610810 DMHLBZR DI DMHLBZR DMHLBZR DN P-IODOAMPHETAMINE DMHLBZR MI TTK25J1 DMHLBZR MN Adenosine A1 receptor (ADORA1) DMHLBZR MT DTT DMHLBZR MA Inhibitor DMHLBZR RN Synthesis and biological activity of N6-(p-sulfophenyl)alkyl and N6-sulfoalkyl derivatives of adenosine: water-soluble and peripherally selective a... J Med Chem. 1992 Oct 30;35(22):4143-9. DMHLBZR RU https://pubmed.ncbi.nlm.nih.gov/1433217 DMOZV7N DI DMOZV7N DMOZV7N DN PIP2 DMOZV7N MI TT9EUT4 DMOZV7N MN Hyperpolarization cyclic nucleotide-gated channel 2 (HCN2) DMOZV7N MT DTT DMOZV7N MA Activator DMOZV7N RN Regulation of gating and rundown of HCN hyperpolarization-activated channels by exogenous and endogenous PIP2. J Gen Physiol. 2006 Nov;128(5):593-604. DMOZV7N RU https://pubmed.ncbi.nlm.nih.gov/17074978 DMOZV7N DI DMOZV7N DMOZV7N DN PIP2 DMOZV7N MI TTH7UO3 DMOZV7N MN Inward rectifier potassium channel Kir2.1 (KCNJ2) DMOZV7N MT DTT DMOZV7N MA Activator DMOZV7N RN Multiple PIP2 binding sites in Kir2.1 inwardly rectifying potassium channels. FEBS Lett. 2001 Feb 9;490(1-2):49-53. DMOZV7N RU https://pubmed.ncbi.nlm.nih.gov/11172809 DMOZV7N DI DMOZV7N DMOZV7N DN PIP2 DMOZV7N MI TTGM19J DMOZV7N MN Inward rectifier potassium channel Kir3.1 (KCNJ3) DMOZV7N MT DTT DMOZV7N MA Activator DMOZV7N RN Direct activation of inward rectifier potassium channels by PIP2 and its stabilization by Gbetagamma. Nature. 1998 Feb 19;391(6669):803-6. DMOZV7N RU https://pubmed.ncbi.nlm.nih.gov/9486652 DMOZV7N DI DMOZV7N DMOZV7N DN PIP2 DMOZV7N MI TTTIBVP DMOZV7N MN Inward rectifier potassium channel Kir3.2 (KCNJ6) DMOZV7N MT DTT DMOZV7N MA Activator DMOZV7N RN Direct activation of inward rectifier potassium channels by PIP2 and its stabilization by Gbetagamma. Nature. 1998 Feb 19;391(6669):803-6. DMOZV7N RU https://pubmed.ncbi.nlm.nih.gov/9486652 DMOZV7N DI DMOZV7N DMOZV7N DN PIP2 DMOZV7N MI TT4VHL6 DMOZV7N MN Inward rectifier potassium channel Kir3.3 (KCNJ9) DMOZV7N MT DTT DMOZV7N MA Activator DMOZV7N RN Regulation of cardiac Na+,Ca2+ exchange and KATP potassium channels by PIP2. Science. 1996 Aug 16;273(5277):956-9. DMOZV7N RU https://pubmed.ncbi.nlm.nih.gov/8688080 DMOZV7N DI DMOZV7N DMOZV7N DN PIP2 DMOZV7N MI TTEO25X DMOZV7N MN Inward rectifier potassium channel Kir3.4 (KCNJ5) DMOZV7N MT DTT DMOZV7N MA Activator DMOZV7N RN PIP2 and PIP as determinants for ATP inhibition of KATP channels. Science. 1998 Nov 6;282(5391):1141-4. DMOZV7N RU https://pubmed.ncbi.nlm.nih.gov/9804555 DMOZV7N DI DMOZV7N DMOZV7N DN PIP2 DMOZV7N MI TT5HWAT DMOZV7N MN IP3 receptor isoform 1 (ITPR1) DMOZV7N MT DTT DMOZV7N MA Antagonist DMOZV7N RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 743). DMOZV7N RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=743 DMOZV7N DI DMOZV7N DMOZV7N DN PIP2 DMOZV7N MI TTJ2HKA DMOZV7N MN Long transient receptor potential channel 4 (TRPM4) DMOZV7N MT DTT DMOZV7N MA Activator DMOZV7N RN Phosphatidylinositol 4,5-bisphosphate rescues TRPM4 channels from desensitization. J Biol Chem. 2005 Nov 25;280(47):39185-92. DMOZV7N RU https://pubmed.ncbi.nlm.nih.gov/16186107 DMOZV7N DI DMOZV7N DMOZV7N DN PIP2 DMOZV7N MI TTFPVZO DMOZV7N MN Long transient receptor potential channel 7 (TRPM7) DMOZV7N MT DTT DMOZV7N MA Activator DMOZV7N RN The TRPM7 channel is inactivated by PIP(2) hydrolysis. Nat Cell Biol. 2002 May;4(5):329-36. DMOZV7N RU https://pubmed.ncbi.nlm.nih.gov/11941371 DMOZV7N DI DMOZV7N DMOZV7N DN PIP2 DMOZV7N MI TTRLMKF DMOZV7N MN Phospholipase D2 (PLD2) DMOZV7N MT DTT DMOZV7N MA Activator DMOZV7N RN Cloning and initial characterization of a human phospholipase D2 (hPLD2). ADP-ribosylation factor regulates hPLD2. J Biol Chem. 1998 May 22;273(21):12846-52. DMOZV7N RU https://pubmed.ncbi.nlm.nih.gov/9582313 DMOZV7N DI DMOZV7N DMOZV7N DN PIP2 DMOZV7N MI TTPXI3S DMOZV7N MN Voltage-gated potassium channel Kv7.2 (KCNQ2) DMOZV7N MT DTT DMOZV7N MA Activator DMOZV7N RN Regulation of Kv7 (KCNQ) K+ channel open probability by phosphatidylinositol 4,5-bisphosphate. J Neurosci. 2005 Oct 26;25(43):9825-35. DMOZV7N RU https://pubmed.ncbi.nlm.nih.gov/16251430 DMOZV7N DI DMOZV7N DMOZV7N DN PIP2 DMOZV7N MI TT8HGRW DMOZV7N MN Voltage-gated potassium channel Kv7.4 (KCNQ4) DMOZV7N MT DTT DMOZV7N MA Activator DMOZV7N RN Regulation of Kv7 (KCNQ) K+ channel open probability by phosphatidylinositol 4,5-bisphosphate. J Neurosci. 2005 Oct 26;25(43):9825-35. DMOZV7N RU https://pubmed.ncbi.nlm.nih.gov/16251430 DMJX39N DI DMJX39N DMJX39N DN PIP3 DMJX39N MI TT8SJGB DMJX39N MN Cyclic nucleotide-gated channel alpha-2 (CNGA2) DMJX39N MT DTT DMJX39N MA Inhibitor (gating inhibitor) DMJX39N RN Interplay between PIP3 and calmodulin regulation of olfactory cyclic nucleotide-gated channels. Proc Natl Acad Sci U S A. 2006 Oct 17;103(42):15635-40. DMJX39N RU https://pubmed.ncbi.nlm.nih.gov/17032767 DMN8OR2 DI DMN8OR2 DMN8OR2 DN Piperidin-(2E)-ylideneamine DMN8OR2 MI TTZUFI5 DMN8OR2 MN Nitric-oxide synthase brain (NOS1) DMN8OR2 MT DTT DMN8OR2 MA Inhibitor DMN8OR2 RN Bicyclic amidine inhibitors of nitric oxide synthase: discovery of perhydro-iminopyrindine and perhydro-iminoquinoline as potent, orally active inh... Bioorg Med Chem Lett. 2005 Apr 15;15(8):1997-2001. DMN8OR2 RU https://pubmed.ncbi.nlm.nih.gov/15808455 DMN8OR2 DI DMN8OR2 DMN8OR2 DN Piperidin-(2E)-ylideneamine DMN8OR2 MI TTCM4B3 DMN8OR2 MN Nitric-oxide synthase endothelial (NOS3) DMN8OR2 MT DTT DMN8OR2 MA Inhibitor DMN8OR2 RN Bicyclic amidine inhibitors of nitric oxide synthase: discovery of perhydro-iminopyrindine and perhydro-iminoquinoline as potent, orally active inh... Bioorg Med Chem Lett. 2005 Apr 15;15(8):1997-2001. DMN8OR2 RU https://pubmed.ncbi.nlm.nih.gov/15808455 DMN8OR2 DI DMN8OR2 DMN8OR2 DN Piperidin-(2E)-ylideneamine DMN8OR2 MI TTF10I9 DMN8OR2 MN Nitric-oxide synthase inducible (NOS2) DMN8OR2 MT DTT DMN8OR2 MA Inhibitor DMN8OR2 RN Bicyclic amidine inhibitors of nitric oxide synthase: discovery of perhydro-iminopyrindine and perhydro-iminoquinoline as potent, orally active inh... Bioorg Med Chem Lett. 2005 Apr 15;15(8):1997-2001. DMN8OR2 RU https://pubmed.ncbi.nlm.nih.gov/15808455 DMKYF5U DI DMKYF5U DMKYF5U DN Piperidine-1-carboxamidine DMKYF5U MI TT2WR1T DMKYF5U MN Cationic trypsinogen (PRSS1) DMKYF5U MT DTT DMKYF5U MA Inhibitor DMKYF5U RN GRID/CPCA: a new computational tool to design selective ligands. J Med Chem. 2000 Aug 10;43(16):3033-44. DMKYF5U RU https://pubmed.ncbi.nlm.nih.gov/10956211 DMF375O DI DMF375O DMF375O DN Piperidine-1-carboxylic acid adamantan-2-yl ester DMF375O MI TTN7BL9 DMF375O MN Corticosteroid 11-beta-dehydrogenase 1 (HSD11B1) DMF375O MT DTT DMF375O MA Inhibitor DMF375O RN Discovery and optimization of adamantyl carbamate inhibitors of 11-HSD1. Bioorg Med Chem Lett. 2010 Nov 15;20(22):6725-9. DMF375O RU https://pubmed.ncbi.nlm.nih.gov/20864344 DMHZFK1 DI DMHZFK1 DMHZFK1 DN Piperidine-1-carboxylic acid adamantan-2-ylamide DMHZFK1 MI TTN7BL9 DMHZFK1 MN Corticosteroid 11-beta-dehydrogenase 1 (HSD11B1) DMHZFK1 MT DTT DMHZFK1 MA Inhibitor DMHZFK1 RN Discovery and optimization of adamantyl carbamate inhibitors of 11-HSD1. Bioorg Med Chem Lett. 2010 Nov 15;20(22):6725-9. DMHZFK1 RU https://pubmed.ncbi.nlm.nih.gov/20864344 DMMIZWE DI DMMIZWE DMMIZWE DN piperidine-4-sulphonic acid DMMIZWE MI TTBMV1G DMMIZWE MN GABA(A) receptor alpha-2 (GABRA2) DMMIZWE MT DTT DMMIZWE MA Agonist DMMIZWE RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 405). DMMIZWE RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=405 DMMIZWE DI DMMIZWE DMMIZWE DN piperidine-4-sulphonic acid DMMIZWE MI TT37EDJ DMMIZWE MN GABA(A) receptor alpha-3 (GABRA3) DMMIZWE MT DTT DMMIZWE MA Agonist DMMIZWE RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 406). DMMIZWE RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=406 DMMIZWE DI DMMIZWE DMMIZWE DN piperidine-4-sulphonic acid DMMIZWE MI TTNZPQ1 DMMIZWE MN GABA(A) receptor alpha-5 (GABRA5) DMMIZWE MT DTT DMMIZWE MA Agonist DMMIZWE RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 408). DMMIZWE RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=408 DMMIZWE DI DMMIZWE DMMIZWE DN piperidine-4-sulphonic acid DMMIZWE MI TTEX6LM DMMIZWE MN GABA(A) receptor gamma-3 (GABRG3) DMMIZWE MT DTT DMMIZWE MA Agonist DMMIZWE RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 415). DMMIZWE RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=415 DMMIZWE DI DMMIZWE DMMIZWE DN piperidine-4-sulphonic acid DMMIZWE MI TT6XFEU DMMIZWE MN GABA(A) receptor rho1 (GABRR1) DMMIZWE MT DTT DMMIZWE MA Antagonist DMMIZWE RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 420). DMMIZWE RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=420 DMMIZWE DI DMMIZWE DMMIZWE DN piperidine-4-sulphonic acid DMMIZWE MI TTQMXLS DMMIZWE MN GABA(A) receptor rho2 (GABRR2) DMMIZWE MT DTT DMMIZWE MA Antagonist DMMIZWE RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 421). DMMIZWE RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=421 DMMIZWE DI DMMIZWE DMMIZWE DN piperidine-4-sulphonic acid DMMIZWE MI TT4N6D8 DMMIZWE MN GABA(A) receptor rho3 (GABRR3) DMMIZWE MT DTT DMMIZWE MA Antagonist DMMIZWE RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 422). DMMIZWE RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=422 DMB3NZA DI DMB3NZA DMB3NZA DN PIPERNONALINE DMB3NZA MI TTA1L39 DMB3NZA MN ICAM1 messenger RNA (ICAM1 mRNA) DMB3NZA MT DTT DMB3NZA MA Inhibitor DMB3NZA RN Alkamides from the fruits of Piper longum and Piper nigrum displaying potent cell adhesion inhibition. Bioorg Med Chem Lett. 2008 Aug 15;18(16):4544-6. DMB3NZA RU https://pubmed.ncbi.nlm.nih.gov/18672369 DMIHO0P DI DMIHO0P DMIHO0P DN PIPEROXAN DMIHO0P MI TTWG9A4 DMIHO0P MN Adrenergic receptor alpha-2A (ADRA2A) DMIHO0P MT DTT DMIHO0P MA Inhibitor DMIHO0P RN alpha 2 adrenoceptors: classification, localization, mechanisms, and targets for drugs. J Med Chem. 1982 Dec;25(12):1389-401. DMIHO0P RU https://pubmed.ncbi.nlm.nih.gov/6296387 DMIHO0P DI DMIHO0P DMIHO0P DN PIPEROXAN DMIHO0P MI TTWM4TY DMIHO0P MN Adrenergic receptor alpha-2B (ADRA2B) DMIHO0P MT DTT DMIHO0P MA Inhibitor DMIHO0P RN alpha 2 adrenoceptors: classification, localization, mechanisms, and targets for drugs. J Med Chem. 1982 Dec;25(12):1389-401. DMIHO0P RU https://pubmed.ncbi.nlm.nih.gov/6296387 DMIHO0P DI DMIHO0P DMIHO0P DN PIPEROXAN DMIHO0P MI TT2NUT5 DMIHO0P MN Adrenergic receptor alpha-2C (ADRA2C) DMIHO0P MT DTT DMIHO0P MA Inhibitor DMIHO0P RN alpha 2 adrenoceptors: classification, localization, mechanisms, and targets for drugs. J Med Chem. 1982 Dec;25(12):1389-401. DMIHO0P RU https://pubmed.ncbi.nlm.nih.gov/6296387 DMRVHWZ DI DMRVHWZ DMRVHWZ DN PIPERROLEIN B DMRVHWZ MI TTA1L39 DMRVHWZ MN ICAM1 messenger RNA (ICAM1 mRNA) DMRVHWZ MT DTT DMRVHWZ MA Inhibitor DMRVHWZ RN Alkamides from the fruits of Piper longum and Piper nigrum displaying potent cell adhesion inhibition. Bioorg Med Chem Lett. 2008 Aug 15;18(16):4544-6. DMRVHWZ RU https://pubmed.ncbi.nlm.nih.gov/18672369 DMOE39X DI DMOE39X DMOE39X DN Piragliatin DMOE39X MI TTDLNGZ DMOE39X MN Glucokinase (GCK) DMOE39X MT DTT DMOE39X MA Modulator DMOE39X RN Piragliatin (RO4389620), a novel glucokinase activator, lowers plasma glucose both in the postabsorptive state and after a glucose challenge in patients with type 2 diabetes mellitus: a mechanistic study.J Clin Endocrinol Metab.2010 Nov;95(11):5028-36. DMOE39X RU https://www.ncbi.nlm.nih.gov/pubmed/20739378 DM9T2G3 DI DM9T2G3 DM9T2G3 DN pirenperone DM9T2G3 MI TTO9X1H DM9T2G3 MN 5-HT 7 receptor (HTR7) DM9T2G3 MT DTT DM9T2G3 MA Antagonist DM9T2G3 RN Cloning, expression and pharmacology of a truncated splice variant of the human 5-HT7 receptor (h5-HT7b). Br J Pharmacol. 1997 Sep;122(1):126-32. DM9T2G3 RU https://pubmed.ncbi.nlm.nih.gov/9298538 DM0SCDR DI DM0SCDR DM0SCDR DN Piretanide DM0SCDR MI TTS087L DM0SCDR MN Solute carrier family 12 member 1 (SLC12A1) DM0SCDR MT DTT DM0SCDR MA Blocker DM0SCDR RN Peripheral and central antinociceptive action of Na+-K+-2Cl- cotransporter blockers on formalin-induced nociception in rats. Pain. 2005 Mar;114(1-2):231-8. DM0SCDR RU https://pubmed.ncbi.nlm.nih.gov/15733649 DMNP6QD DI DMNP6QD DMNP6QD DN piribedil DMNP6QD MI TTSQIFT DMNP6QD MN 5-HT 1A receptor (HTR1A) DMNP6QD MT DTT DMNP6QD MA Agonist DMNP6QD RN Differential actions of antiparkinson agents at multiple classes of monoaminergic receptor. I. A multivariate analysis of the binding profiles of 14 drugs at 21 native and cloned human receptor subtypes. J Pharmacol Exp Ther. 2002 Nov;303(2):791-804. DMNP6QD RU https://pubmed.ncbi.nlm.nih.gov/12388666 DMNP6QD DI DMNP6QD DMNP6QD DN piribedil DMNP6QD MI TT0K1SC DMNP6QD MN 5-HT 2B receptor (HTR2B) DMNP6QD MT DTT DMNP6QD MA Antagonist DMNP6QD RN Differential actions of antiparkinson agents at multiple classes of monoaminergic receptor. I. A multivariate analysis of the binding profiles of 14 drugs at 21 native and cloned human receptor subtypes. J Pharmacol Exp Ther. 2002 Nov;303(2):791-804. DMNP6QD RU https://pubmed.ncbi.nlm.nih.gov/12388666 DMNP6QD DI DMNP6QD DMNP6QD DN piribedil DMNP6QD MI TT2NUT5 DMNP6QD MN Adrenergic receptor alpha-2C (ADRA2C) DMNP6QD MT DTT DMNP6QD MA Antagonist DMNP6QD RN Differential actions of antiparkinson agents at multiple classes of monoaminergic receptor. I. A multivariate analysis of the binding profiles of 14 drugs at 21 native and cloned human receptor subtypes. J Pharmacol Exp Ther. 2002 Nov;303(2):791-804. DMNP6QD RU https://pubmed.ncbi.nlm.nih.gov/12388666 DMNP6QD DI DMNP6QD DMNP6QD DN piribedil DMNP6QD MI TTEX248 DMNP6QD MN Dopamine D2 receptor (D2R) DMNP6QD MT DTT DMNP6QD MA Agonist DMNP6QD RN Differential actions of antiparkinson agents at multiple classes of monoaminergic receptor. I. A multivariate analysis of the binding profiles of 14 drugs at 21 native and cloned human receptor subtypes. J Pharmacol Exp Ther. 2002 Nov;303(2):791-804. DMNP6QD RU https://pubmed.ncbi.nlm.nih.gov/12388666 DMNP6QD DI DMNP6QD DMNP6QD DN piribedil DMNP6QD MI TT4C8EA DMNP6QD MN Dopamine D3 receptor (D3R) DMNP6QD MT DTT DMNP6QD MA Agonist DMNP6QD RN Differential actions of antiparkinson agents at multiple classes of monoaminergic receptor. I. A multivariate analysis of the binding profiles of 14 drugs at 21 native and cloned human receptor subtypes. J Pharmacol Exp Ther. 2002 Nov;303(2):791-804. DMNP6QD RU https://pubmed.ncbi.nlm.nih.gov/12388666 DMNP6QD DI DMNP6QD DMNP6QD DN piribedil DMNP6QD MI TTE0A2F DMNP6QD MN Dopamine D4 receptor (D4R) DMNP6QD MT DTT DMNP6QD MA Antagonist DMNP6QD RN Differential actions of antiparkinson agents at multiple classes of monoaminergic receptor. I. A multivariate analysis of the binding profiles of 14 drugs at 21 native and cloned human receptor subtypes. J Pharmacol Exp Ther. 2002 Nov;303(2):791-804. DMNP6QD RU https://pubmed.ncbi.nlm.nih.gov/12388666 DMRDF8Z DI DMRDF8Z DMRDF8Z DN Piridronic acid DMRDF8Z MI TTIKWV4 DMRDF8Z MN Geranyltranstransferase (FDPS) DMRDF8Z MT DTT DMRDF8Z MA Inhibitor DMRDF8Z RN Structure-activity relationships among the nitrogen containing bisphosphonates in clinical use and other analogues: time-dependent inhibition of hu... J Med Chem. 2008 Apr 10;51(7):2187-95. DMRDF8Z RU https://pubmed.ncbi.nlm.nih.gov/18327899 DM7XTHD DI DM7XTHD DM7XTHD DN Piriqualone DM7XTHD MI TTAN6JD DM7XTHD MN Glutamate receptor AMPA (GRIA) DM7XTHD MT DTT DM7XTHD MA Inhibitor DM7XTHD RN Atropisomeric quinazolin-4-one derivatives are potent noncompetitive alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor antag... Bioorg Med Chem Lett. 2001 Jan 22;11(2):177-81. DM7XTHD RU https://pubmed.ncbi.nlm.nih.gov/11206453 DM7XTHD DI DM7XTHD DM7XTHD DN Piriqualone DM7XTHD MI TTVPQTF DM7XTHD MN Glutamate receptor AMPA 1 (GRIA1) DM7XTHD MT DTT DM7XTHD MA Inhibitor DM7XTHD RN Atropisomeric quinazolin-4-one derivatives are potent noncompetitive alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor antag... Bioorg Med Chem Lett. 2001 Jan 22;11(2):177-81. DM7XTHD RU https://pubmed.ncbi.nlm.nih.gov/11206453 DMWLDRJ DI DMWLDRJ DMWLDRJ DN PIROTIODECANE DMWLDRJ MI TTXLO8T DMWLDRJ MN Potential penetration (PP) DMWLDRJ MT DTT DMWLDRJ MA Modulator DMWLDRJ RN Effectiveness of pirotiodecane, absorption enhancer, on nasal absorption in rabbits. Drug Metab Pharmacokinet. 2005 Feb;20(1):65-71. DMWLDRJ RU https://pubmed.ncbi.nlm.nih.gov/15770076 DMKHZQW DI DMKHZQW DMKHZQW DN Pitrazepine DMKHZQW MI TTNJYV2 DMKHZQW MN Gamma-aminobutyric acid receptor (GAR) DMKHZQW MT DTT DMKHZQW MA Inhibitor DMKHZQW RN Structure and molecular modeling of GABAA receptor antagonists. J Med Chem. 1992 May 29;35(11):1969-77. DMKHZQW RU https://pubmed.ncbi.nlm.nih.gov/1317920 DMVYNTB DI DMVYNTB DMVYNTB DN Piv-RYYRIK-NH2 DMVYNTB MI TTNT7K8 DMVYNTB MN Nociceptin receptor (OPRL1) DMVYNTB MT DTT DMVYNTB MA Inhibitor DMVYNTB RN Designed modification of partial agonist of ORL1 nociceptin receptor for conversion into highly potent antagonist. Bioorg Med Chem. 2008 Mar 1;16(5):2635-44. DMVYNTB RU https://pubmed.ncbi.nlm.nih.gov/18068993 DMDOZPU DI DMDOZPU DMDOZPU DN PK 11195 DMDOZPU MI TTGJVQM DMDOZPU MN Fibroblast growth factor receptor 2 (FGFR2) DMDOZPU MT DTT DMDOZPU MA Binder DMDOZPU RN DrugBank: a knowledgebase for drugs, drug actions and drug targets. Nucleic Acids Res. 2008 Jan;36(Database issue):D901-6. DMDOZPU RU https://pubmed.ncbi.nlm.nih.gov/18048412 DMDOZPU DI DMDOZPU DMDOZPU DN PK 11195 DMDOZPU MI TTPTXIN DMDOZPU MN Translocator protein (TSPO) DMDOZPU MT DTT DMDOZPU MA Binder DMDOZPU RN Specific ligands of the peripheral benzodiazepine receptor induce apoptosis and cell cycle arrest in human colorectal cancer cells. Br J Cancer. 2001 Nov 30;85(11):1771-80. DMDOZPU RU https://pubmed.ncbi.nlm.nih.gov/11742501 DM40HWI DI DM40HWI DM40HWI DN PK-44 DM40HWI MI TTDIGC1 DM40HWI MN Dipeptidyl peptidase 4 (DPP-4) DM40HWI MT DTT DM40HWI MA Inhibitor DM40HWI RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1612). DM40HWI RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1612 DMIUZGY DI DMIUZGY DMIUZGY DN PK68 DMIUZGY MI TTAIQSN DMIUZGY MN Receptor-interacting protein 1 (RIPK1) DMIUZGY MT DTT DMIUZGY MA Inhibitor DMIUZGY RN Discovery of potent necroptosis inhibitors targeting RIPK1 kinase activity for the treatment of inflammatory disorder and cancer metastasis. Cell Death Dis. 2019 Jun 24;10(7):493. DMIUZGY RU https://pubmed.ncbi.nlm.nih.gov/31235688 DM04C9V DI DM04C9V DM04C9V DN PKF-241-466 DM04C9V MI TT6AZXG DM04C9V MN TNF alpha converting enzyme (ADAM17) DM04C9V MT DTT DM04C9V MA Inhibitor DM04C9V RN Current perspective of TACE inhibitors: a review. Bioorg Med Chem. 2009 Jan 15;17(2):444-59. DM04C9V RU https://pubmed.ncbi.nlm.nih.gov/19095454 DM04C9V DI DM04C9V DM04C9V DN PKF-241-466 DM04C9V MI TTF8CQI DM04C9V MN Tumor necrosis factor (TNF) DM04C9V MT DTT DM04C9V MA Inhibitor DM04C9V RN Beta-aryl-succinic acid hydroxamates as dual inhibitors of matrix metalloproteinases and tumor necrosis factor alpha converting enzyme. J Med Chem. 2002 May 23;45(11):2289-93. DM04C9V RU https://pubmed.ncbi.nlm.nih.gov/12014967 DMNDLAS DI DMNDLAS DMNDLAS DN PKF-242-484 DMNDLAS MI TTMX39J DMNDLAS MN Matrix metalloproteinase-1 (MMP-1) DMNDLAS MT DTT DMNDLAS MA Inhibitor DMNDLAS RN A cassette-dosing approach for improvement of oral bioavailability of dual TACE/MMP inhibitors. Bioorg Med Chem Lett. 2006 May 15;16(10):2632-6. DMNDLAS RU https://pubmed.ncbi.nlm.nih.gov/16516469 DMNDLAS DI DMNDLAS DMNDLAS DN PKF-242-484 DMNDLAS MI TTHY57M DMNDLAS MN Matrix metalloproteinase-13 (MMP-13) DMNDLAS MT DTT DMNDLAS MA Inhibitor DMNDLAS RN A cassette-dosing approach for improvement of oral bioavailability of dual TACE/MMP inhibitors. Bioorg Med Chem Lett. 2006 May 15;16(10):2632-6. DMNDLAS RU https://pubmed.ncbi.nlm.nih.gov/16516469 DMNDLAS DI DMNDLAS DMNDLAS DN PKF-242-484 DMNDLAS MI TTUZ2L5 DMNDLAS MN Matrix metalloproteinase-3 (MMP-3) DMNDLAS MT DTT DMNDLAS MA Inhibitor DMNDLAS RN A cassette-dosing approach for improvement of oral bioavailability of dual TACE/MMP inhibitors. Bioorg Med Chem Lett. 2006 May 15;16(10):2632-6. DMNDLAS RU https://pubmed.ncbi.nlm.nih.gov/16516469 DMNDLAS DI DMNDLAS DMNDLAS DN PKF-242-484 DMNDLAS MI TT6AZXG DMNDLAS MN TNF alpha converting enzyme (ADAM17) DMNDLAS MT DTT DMNDLAS MA Inhibitor DMNDLAS RN Current perspective of TACE inhibitors: a review. Bioorg Med Chem. 2009 Jan 15;17(2):444-59. DMNDLAS RU https://pubmed.ncbi.nlm.nih.gov/19095454 DMNDLAS DI DMNDLAS DMNDLAS DN PKF-242-484 DMNDLAS MI TTF8CQI DMNDLAS MN Tumor necrosis factor (TNF) DMNDLAS MT DTT DMNDLAS MA Inhibitor DMNDLAS RN Beta-aryl-succinic acid hydroxamates as dual inhibitors of matrix metalloproteinases and tumor necrosis factor alpha converting enzyme. J Med Chem. 2002 May 23;45(11):2289-93. DMNDLAS RU https://pubmed.ncbi.nlm.nih.gov/12014967 DM6NX4H DI DM6NX4H DM6NX4H DN PKI-402 DM6NX4H MI TTHBTOP DM6NX4H MN PI3-kinase gamma (PIK3CG) DM6NX4H MT DTT DM6NX4H MA Inhibitor DM6NX4H RN Lead optimization of N-3-substituted 7-morpholinotriazolopyrimidines as dual phosphoinositide 3-kinase/mammalian target of rapamycin inhibitors: di... J Med Chem. 2010 Jan 28;53(2):798-810. DM6NX4H RU https://pubmed.ncbi.nlm.nih.gov/19968288 DMSJCKN DI DMSJCKN DMSJCKN DN PKR-A DMSJCKN MI TTM67AX DMSJCKN MN Prokineticin receptor 2 (PKR2) DMSJCKN MT DTT DMSJCKN MA Antagonist DMSJCKN RN Prokineticin 2 is an endangering mediator of cerebral ischemic injury. Proc Natl Acad Sci U S A. 2012 Apr 3;109(14):5475-80. DMSJCKN RU https://pubmed.ncbi.nlm.nih.gov/22431614 DMICVXN DI DMICVXN DMICVXN DN PL017 DMICVXN MI TTKWM86 DMICVXN MN Opioid receptor mu (MOP) DMICVXN MT DTT DMICVXN MA Agonist DMICVXN RN Potent morphiceptin analogs: structure activity relationships and morphine-like activities. J Pharmacol Exp Ther. 1983 Nov;227(2):403-8. DMICVXN RU https://pubmed.ncbi.nlm.nih.gov/6313901 DMWHNZ4 DI DMWHNZ4 DMWHNZ4 DN Plantainoside D DMWHNZ4 MI TTFJ8Q1 DMWHNZ4 MN Protein kinase C alpha (PRKCA) DMWHNZ4 MT DTT DMWHNZ4 MA Inhibitor DMWHNZ4 RN Phenylethanoid glycosides from Digitalis purpurea and Penstemon linarioides with PKCalpha-inhibitory activity. J Nat Prod. 1998 Nov;61(11):1410-2. DMWHNZ4 RU https://pubmed.ncbi.nlm.nih.gov/9834166 DMV34O2 DI DMV34O2 DMV34O2 DN Platelet factor 4 (PF-4) DMV34O2 MI TTGJVQM DMV34O2 MN Fibroblast growth factor receptor 2 (FGFR2) DMV34O2 MT DTT DMV34O2 MA Inhibitor DMV34O2 RN A short peptide domain of platelet factor 4 blocks angiogenic key events induced by FGF-2. FASEB J. 2001 Mar;15(3):550-2. DMV34O2 RU https://pubmed.ncbi.nlm.nih.gov/11259363 DM9N0RH DI DM9N0RH DM9N0RH DN PLATENSIMYCIN DM9N0RH MI TTRFV0W DM9N0RH MN Bacterial Oxoacyl-[acyl-carrier-protein] synthase II (Bact fabF) DM9N0RH MT DTT DM9N0RH MA Inhibitor DM9N0RH RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DM9N0RH RU https://pubmed.ncbi.nlm.nih.gov/10592235 DM4MKIX DI DM4MKIX DM4MKIX DN Ploglitazone DM4MKIX MI TTT2SVW DM4MKIX MN PPAR-gamma messenger RNA (PPARG mRNA) DM4MKIX MT DTT DM4MKIX MA Inhibitor DM4MKIX RN Peroxisome proliferator-activated receptor alpha/gamma dual agonists for the treatment of type 2 diabetes. J Med Chem. 2004 Aug 12;47(17):4118-27. DM4MKIX RU https://pubmed.ncbi.nlm.nih.gov/15293980 DMBN4V6 DI DMBN4V6 DMBN4V6 DN PLSQETFSDLWKLLPEN-NH2 DMBN4V6 MI TT9TE0O DMBN4V6 MN Mdm2 messenger RNA (MDM2 mRNA) DMBN4V6 MT DTT DMBN4V6 MA Inhibitor DMBN4V6 RN Structure-based design of spiro-oxindoles as potent, specific small-molecule inhibitors of the MDM2-p53 interaction. J Med Chem. 2006 Jun 15;49(12):3432-5. DMBN4V6 RU https://pubmed.ncbi.nlm.nih.gov/16759082 DM9BS50 DI DM9BS50 DM9BS50 DN Plumbagin DM9BS50 MI TT3PQ2Y DM9BS50 MN Plasmodium Dihydroorotate dehydrogenase (Malaria DHOdehase) DM9BS50 MT DTT DM9BS50 MA Inhibitor DM9BS50 RN Kinetics of inhibition of human and rat dihydroorotate dehydrogenase by atovaquone, lawsone derivatives, brequinar sodium and polyporic acid. Chem Biol Interact. 2000 Jan 3;124(1):61-76. DM9BS50 RU https://pubmed.ncbi.nlm.nih.gov/10658902 DMZG1L5 DI DMZG1L5 DMZG1L5 DN PLX-ORI3 DMZG1L5 MI TT0EOB8 DMZG1L5 MN B-Raf messenger RNA (BRAF mRNA) DMZG1L5 MT DTT DMZG1L5 MA Inhibitor DMZG1L5 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1943). DMZG1L5 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1943 DMZG1L5 DI DMZG1L5 DMZG1L5 DN PLX-ORI3 DMZG1L5 MI TTAN5W2 DMZG1L5 MN Raf messenger RNA (Raf mRNA) DMZG1L5 MT DTT DMZG1L5 MA Inhibitor DMZG1L5 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2184). DMZG1L5 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2184 DMU6972 DI DMU6972 DMU6972 DN PMBA DMU6972 MI TTZ8EM9 DMU6972 MN Glycine receptor (GlyR) DMU6972 MT DTT DMU6972 MA Antagonist DMU6972 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 425). DMU6972 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=425 DMEYHWN DI DMEYHWN DMEYHWN DN PMD38 DMEYHWN MI TTXDKTO DMEYHWN MN Long transient receptor potential channel 8 (TRPM8) DMEYHWN MT DTT DMEYHWN MA Activator DMEYHWN RN Characterization of the mouse cold-menthol receptor TRPM8 and vanilloid receptor type-1 VR1 using a fluorometric imaging plate reader (FLIPR) assay. Br J Pharmacol. 2004 Feb;141(4):737-45. DMEYHWN RU https://pubmed.ncbi.nlm.nih.gov/14757700 DMBKVJY DI DMBKVJY DMBKVJY DN PMEA DMBKVJY MI TTIU7X1 DMBKVJY MN Herpes simplex virus DNA polymerase UL30 (HSV UL30) DMBKVJY MT DTT DMBKVJY MA Inhibitor DMBKVJY RN Herpes simplex virus-specified DNA polymerase is the target for the antiviral action of 9-(2-phosphonylmethoxyethyl)adenine. J Biol Chem. 1991 Jan 5;266(1):238-44. DMBKVJY RU https://pubmed.ncbi.nlm.nih.gov/1845964 DMHX704 DI DMHX704 DMHX704 DN PMI-008 DMHX704 MI TTLUQ8E DMHX704 MN Hormone sensitive lipase (LIPE) DMHX704 MT DTT DMHX704 MA Modulator DMHX704 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2593). DMHX704 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2593 DM7SDNI DI DM7SDNI DM7SDNI DN PMID10395480C6 DM7SDNI MI TTI9MBZ DM7SDNI MN X-prolyl aminopeptidase 2 (XPNPEP2) DM7SDNI MT DTT DM7SDNI MA Inhibitor DM7SDNI RN Apstatin analogue inhibitors of aminopeptidase P, a bradykinin-degrading enzyme. J Med Chem. 1999 Jul 1;42(13):2394-402. DM7SDNI RU https://pubmed.ncbi.nlm.nih.gov/10395480 DMLH73O DI DMLH73O DMLH73O DN PMID10602705C40 DMLH73O MI TT9PBIL DMLH73O MN Glutamyl aminopeptidase (ENPEP) DMLH73O MT DTT DMLH73O MA Inhibitor DMLH73O RN Investigation of subsite preferences in aminopeptidase A (EC 3.4.11.7) led to the design of the first highly potent and selective inhibitors of this enzyme. J Med Chem. 1999 Dec 16;42(25):5197-211. DMLH73O RU https://pubmed.ncbi.nlm.nih.gov/10602705 DMU0AGE DI DMU0AGE DMU0AGE DN PMID11934595C2 DMU0AGE MI TT0L58T DMU0AGE MN Bone morphogenetic protein 1 (BMP1) DMU0AGE MT DTT DMU0AGE MA Inhibitor DMU0AGE RN Amino acid derived sulfonamide hydroxamates as inhibitors of procollagen C-proteinase. Part 2: Solid-phase optimization of side chains. Bioorg Med Chem Lett. 2002 Apr 22;12(8):1233-5. DMU0AGE RU https://pubmed.ncbi.nlm.nih.gov/11934595 DMFO7UC DI DMFO7UC DMFO7UC DN PMID12014956C12 DMFO7UC MI TTIKWV4 DMFO7UC MN Geranyltranstransferase (FDPS) DMFO7UC MT DTT DMFO7UC MA Inhibitor DMFO7UC RN Inhibition of geranylgeranyl diphosphate synthase by bisphosphonates and diphosphates: a potential route to new bone antiresorption and antiparasitic agents. J Med Chem. 2002 May 23;45(11):2185-96. DMFO7UC RU https://pubmed.ncbi.nlm.nih.gov/12014956 DMY7W2U DI DMY7W2U DMY7W2U DN PMID12127536C20 DMY7W2U MI TTKEPHX DMY7W2U MN Granzyme B (GZMB) DMY7W2U MT DTT DMY7W2U MA Inhibitor DMY7W2U RN Discovery of potent, selective human granzyme B inhibitors that inhibit CTL mediated apoptosis. Bioorg Med Chem Lett. 2002 Aug 19;12(16):2197-200. DMY7W2U RU https://pubmed.ncbi.nlm.nih.gov/12127536 DMQZXMF DI DMQZXMF DMQZXMF DN PMID12238936C3a DMQZXMF MI TTFQEO5 DMQZXMF MN Squalene synthetase (FDFT1) DMQZXMF MT DTT DMQZXMF MA Inhibitor DMQZXMF RN Synthesis of novel 4,1-benzoxazepine derivatives as squalene synthase inhibitors and their inhibition of cholesterol synthesis. J Med Chem. 2002 Sep 26;45(20):4571-80. DMQZXMF RU https://pubmed.ncbi.nlm.nih.gov/12238936 DMO5J8N DI DMO5J8N DMO5J8N DN PMID12238936C3f DMO5J8N MI TTFQEO5 DMO5J8N MN Squalene synthetase (FDFT1) DMO5J8N MT DTT DMO5J8N MA Inhibitor DMO5J8N RN Synthesis of novel 4,1-benzoxazepine derivatives as squalene synthase inhibitors and their inhibition of cholesterol synthesis. J Med Chem. 2002 Sep 26;45(20):4571-80. DMO5J8N RU https://pubmed.ncbi.nlm.nih.gov/12238936 DMIW5TY DI DMIW5TY DMIW5TY DN PMID12372533C20 DMIW5TY MI TT3RMNA DMIW5TY MN Chymotrypsin-C (CLCR) DMIW5TY MT DTT DMIW5TY MA Inhibitor DMIW5TY RN P1 Phenethyl peptide boronic acid inhibitors of HCV NS3 protease. Bioorg Med Chem Lett. 2002 Nov 4;12(21):3199-202. DMIW5TY RU https://pubmed.ncbi.nlm.nih.gov/12372533 DM1ISJU DI DM1ISJU DM1ISJU DN PMID12470711C3 DM1ISJU MI TTVBPDM DM1ISJU MN Metabotropic glutamate receptor 1 (mGluR1) DM1ISJU MT DTT DM1ISJU MA Modulator (allosteric modulator) DM1ISJU RN Synthesis and pharmacological characterisation of 2,4-dicarboxy-pyrroles as selective non-competitive mGluR1 antagonists. Bioorg Med Chem. 2003 Jan 17;11(2):171-83. DM1ISJU RU https://pubmed.ncbi.nlm.nih.gov/12470711 DMXFY4P DI DMXFY4P DMXFY4P DN PMID12614873C2b-1 DMXFY4P MI TT8KLPT DMXFY4P MN C-C chemokine receptor (CCR) DMXFY4P MT DTT DMXFY4P MA Antagonist DMXFY4P RN Structure-activity relationships of xanthene carboxamides, novel CCR1 receptor antagonists. Bioorg Med Chem. 2003 Mar 20;11(6):875-84. DMXFY4P RU https://pubmed.ncbi.nlm.nih.gov/12614873 DMR1MCD DI DMR1MCD DMR1MCD DN PMID12723943C12 DMR1MCD MI TTGY8IW DMR1MCD MN B2 bradykinin receptor (BDKRB2) DMR1MCD MT DTT DMR1MCD MA Antagonist DMR1MCD RN Benzodiazepines as potent and selective bradykinin B1 antagonists. J Med Chem. 2003 May 8;46(10):1803-6. DMR1MCD RU https://pubmed.ncbi.nlm.nih.gov/12723943 DM3EZ9Q DI DM3EZ9Q DM3EZ9Q DN PMID12723954C21b DM3EZ9Q MI TTHYDUM DM3EZ9Q MN Bombesin receptor (BS) DM3EZ9Q MT DTT DM3EZ9Q MA Agonist DM3EZ9Q RN Design of selective peptidomimetic agonists for the human orphan receptor BRS-3. J Med Chem. 2003 May 8;46(10):1918-30. DM3EZ9Q RU https://pubmed.ncbi.nlm.nih.gov/12723954 DMYXDK5 DI DMYXDK5 DMYXDK5 DN PMID12812482C11 DMYXDK5 MI TTGY8IW DMYXDK5 MN B2 bradykinin receptor (BDKRB2) DMYXDK5 MT DTT DMYXDK5 MA Antagonist DMYXDK5 RN Discovery of a potent, non-peptide bradykinin B1 receptor antagonist. J Am Chem Soc. 2003 Jun 25;125(25):7516-7. DMYXDK5 RU https://pubmed.ncbi.nlm.nih.gov/12812482 DMR2L6X DI DMR2L6X DMR2L6X DN PMID14640538C3 DMR2L6X MI TT8V2KD DMR2L6X MN Arginine carboxypeptidase (CPN1) DMR2L6X MT DTT DMR2L6X MA Inhibitor DMR2L6X RN Synthesis and evaluation of imidazole acetic acid inhibitors of activated thrombin-activatable fibrinolysis inhibitor as novel antithrombotics. J Med Chem. 2003 Dec 4;46(25):5294-7. DMR2L6X RU https://pubmed.ncbi.nlm.nih.gov/14640538 DMR2L6X DI DMR2L6X DMR2L6X DN PMID14640538C3 DMR2L6X MI TT4UJX5 DMR2L6X MN Carboxypeptidase B1 (CPB1) DMR2L6X MT DTT DMR2L6X MA Inhibitor DMR2L6X RN Synthesis and evaluation of imidazole acetic acid inhibitors of activated thrombin-activatable fibrinolysis inhibitor as novel antithrombotics. J Med Chem. 2003 Dec 4;46(25):5294-7. DMR2L6X RU https://pubmed.ncbi.nlm.nih.gov/14640538 DMR2L6X DI DMR2L6X DMR2L6X DN PMID14640538C3 DMR2L6X MI TTP18AY DMR2L6X MN Carboxypeptidase B2 (CPB2) DMR2L6X MT DTT DMR2L6X MA Inhibitor DMR2L6X RN Synthesis and evaluation of imidazole acetic acid inhibitors of activated thrombin-activatable fibrinolysis inhibitor as novel antithrombotics. J Med Chem. 2003 Dec 4;46(25):5294-7. DMR2L6X RU https://pubmed.ncbi.nlm.nih.gov/14640538 DMR2L6X DI DMR2L6X DMR2L6X DN PMID14640538C3 DMR2L6X MI TTVOH2M DMR2L6X MN Carboxypeptidase M (CPM) DMR2L6X MT DTT DMR2L6X MA Inhibitor DMR2L6X RN Synthesis and evaluation of imidazole acetic acid inhibitors of activated thrombin-activatable fibrinolysis inhibitor as novel antithrombotics. J Med Chem. 2003 Dec 4;46(25):5294-7. DMR2L6X RU https://pubmed.ncbi.nlm.nih.gov/14640538 DMFWCAJ DI DMFWCAJ DMFWCAJ DN PMID14697765C11a DMFWCAJ MI TTHS256 DMFWCAJ MN Metabotropic glutamate receptor 5 (mGluR5) DMFWCAJ MT DTT DMFWCAJ MA Modulator (allosteric modulator) DMFWCAJ RN Discovery of novel modulators of metabotropic glutamate receptor subtype-5. Bioorg Med Chem. 2004 Jan 2;12(1):17-21. DMFWCAJ RU https://pubmed.ncbi.nlm.nih.gov/14697765 DMFT1DO DI DMFT1DO DMFT1DO DN PMID14697765C16a DMFT1DO MI TTHS256 DMFT1DO MN Metabotropic glutamate receptor 5 (mGluR5) DMFT1DO MT DTT DMFT1DO MA Modulator (allosteric modulator) DMFT1DO RN Discovery of novel modulators of metabotropic glutamate receptor subtype-5. Bioorg Med Chem. 2004 Jan 2;12(1):17-21. DMFT1DO RU https://pubmed.ncbi.nlm.nih.gov/14697765 DMOQ8PF DI DMOQ8PF DMOQ8PF DN PMID15027864C8d DMOQ8PF MI TT9G4N0 DMOQ8PF MN Glutamate carboxypeptidase II (GCPII) DMOQ8PF MT DTT DMOQ8PF MA Inhibitor DMOQ8PF RN Synthesis of urea-based inhibitors as active site probes of glutamate carboxypeptidase II: efficacy as analgesic agents. J Med Chem. 2004 Mar 25;47(7):1729-38. DMOQ8PF RU https://pubmed.ncbi.nlm.nih.gov/15027864 DM9V6YK DI DM9V6YK DM9V6YK DN PMID15055993C1a DM9V6YK MI TT6X50U DM9V6YK MN Matrix metalloproteinase-9 (MMP-9) DM9V6YK MT DTT DM9V6YK MA Inhibitor DM9V6YK RN Azasugar-based MMP/ADAM inhibitors as antipsoriatic agents. J Med Chem. 2004 Apr 8;47(8):1930-8. DM9V6YK RU https://pubmed.ncbi.nlm.nih.gov/15055993 DMFI4J6 DI DMFI4J6 DMFI4J6 DN PMID15261275C1 DMFI4J6 MI TT60Q8D DMFI4J6 MN Orexin receptor type 1 (HCRTR1) DMFI4J6 MT DTT DMFI4J6 MA Antagonist DMFI4J6 RN Novel substituted 4-phenyl-[1,3]dioxanes: potent and selective orexin receptor 2 (OX(2)R) antagonists. Bioorg Med Chem Lett. 2004 Aug 16;14(16):4225-9. DMFI4J6 RU https://pubmed.ncbi.nlm.nih.gov/15261275 DMFI4J6 DI DMFI4J6 DMFI4J6 DN PMID15261275C1 DMFI4J6 MI TT9N02I DMFI4J6 MN Orexin receptor type 2 (HCRTR2) DMFI4J6 MT DTT DMFI4J6 MA Antagonist DMFI4J6 RN Novel substituted 4-phenyl-[1,3]dioxanes: potent and selective orexin receptor 2 (OX(2)R) antagonists. Bioorg Med Chem Lett. 2004 Aug 16;14(16):4225-9. DMFI4J6 RU https://pubmed.ncbi.nlm.nih.gov/15261275 DM7JKLM DI DM7JKLM DM7JKLM DN PMID1527791C29 DM7JKLM MI TTPADOQ DM7JKLM MN HMG-CoA reductase (HMGCR) DM7JKLM MT DTT DM7JKLM MA Inhibitor DM7JKLM RN Synthesis and biological evaluation of dihydroeptastatin, a novel inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase. J Med Chem. 1992 Sep 4;35(18):3388-93. DM7JKLM RU https://pubmed.ncbi.nlm.nih.gov/1527791 DMWDE9A DI DMWDE9A DMWDE9A DN PMID15300839C17 DMWDE9A MI TTBUYHA DMWDE9A MN Extracellular calcium-sensing receptor (CASR) DMWDE9A MT DTT DMWDE9A MA Antagonist DMWDE9A RN N(1)-Arylsulfonyl-N(2)-(1-(1-naphthyl)ethyl)-1,2-diaminocyclohexanes: a new class of calcilytic agents acting at the calcium-sensing receptor. Chembiochem. 2004 Aug 6;5(8):1131-6. DMWDE9A RU https://pubmed.ncbi.nlm.nih.gov/15300839 DM7T8BE DI DM7T8BE DM7T8BE DN PMID15482906C10 DM7T8BE MI TTHS256 DM7T8BE MN Metabotropic glutamate receptor 5 (mGluR5) DM7T8BE MT DTT DM7T8BE MA Modulator (allosteric modulator) DM7T8BE RN 2-(2-[3-(pyridin-3-yloxy)phenyl]-2H-tetrazol-5-yl) pyridine: a highly potent, orally active, metabotropic glutamate subtype 5 (mGlu5) receptor antagonist. Bioorg Med Chem Lett. 2004 Nov 15;14(22):5473-6. DM7T8BE RU https://pubmed.ncbi.nlm.nih.gov/15482906 DMCPIQ4 DI DMCPIQ4 DMCPIQ4 DN PMID15482908C8 DMCPIQ4 MI TTHS256 DMCPIQ4 MN Metabotropic glutamate receptor 5 (mGluR5) DMCPIQ4 MT DTT DMCPIQ4 MA Modulator (allosteric modulator) DMCPIQ4 RN Discovery of highly potent, selective, orally bioavailable, metabotropic glutamate subtype 5 (mGlu5) receptor antagonists devoid of cytochrome P450 1A2 inhibitory activity. Bioorg Med Chem Lett. 2004Nov 15;14(22):5481-4. DMCPIQ4 RU https://pubmed.ncbi.nlm.nih.gov/15482908 DMOPUIH DI DMOPUIH DMOPUIH DN PMID15546730C2 DMOPUIH MI TTNDSC3 DMOPUIH MN B lymphocyte kinase (BLK) DMOPUIH MT DTT DMOPUIH MA Inhibitor DMOPUIH RN Discovery of novel 2-(aminoheteroaryl)-thiazole-5-carboxamides as potent and orally active Src-family kinase p56(Lck) inhibitors. Bioorg Med Chem Lett. 2004 Dec 20;14(24):6061-6. DMOPUIH RU https://pubmed.ncbi.nlm.nih.gov/15546730 DMOPUIH DI DMOPUIH DMOPUIH DN PMID15546730C2 DMOPUIH MI TT2B9KF DMOPUIH MN Fyn tyrosine protein kinase (FYN) DMOPUIH MT DTT DMOPUIH MA Inhibitor DMOPUIH RN Discovery of novel 2-(aminoheteroaryl)-thiazole-5-carboxamides as potent and orally active Src-family kinase p56(Lck) inhibitors. Bioorg Med Chem Lett. 2004 Dec 20;14(24):6061-6. DMOPUIH RU https://pubmed.ncbi.nlm.nih.gov/15546730 DMOPUIH DI DMOPUIH DMOPUIH DN PMID15546730C2 DMOPUIH MI TT42OGM DMOPUIH MN Hematopoietic cell kinase (HCK) DMOPUIH MT DTT DMOPUIH MA Inhibitor DMOPUIH RN Discovery of novel 2-(aminoheteroaryl)-thiazole-5-carboxamides as potent and orally active Src-family kinase p56(Lck) inhibitors. Bioorg Med Chem Lett. 2004 Dec 20;14(24):6061-6. DMOPUIH RU https://pubmed.ncbi.nlm.nih.gov/15546730 DMOPUIH DI DMOPUIH DMOPUIH DN PMID15546730C2 DMOPUIH MI TTT7PJU DMOPUIH MN Janus kinase 3 (JAK-3) DMOPUIH MT DTT DMOPUIH MA Inhibitor DMOPUIH RN Discovery of novel 2-(aminoheteroaryl)-thiazole-5-carboxamides as potent and orally active Src-family kinase p56(Lck) inhibitors. Bioorg Med Chem Lett. 2004 Dec 20;14(24):6061-6. DMOPUIH RU https://pubmed.ncbi.nlm.nih.gov/15546730 DMOPUIH DI DMOPUIH DMOPUIH DN PMID15546730C2 DMOPUIH MI TT860QF DMOPUIH MN LCK tyrosine protein kinase (LCK) DMOPUIH MT DTT DMOPUIH MA Inhibitor DMOPUIH RN Discovery of novel 2-(aminoheteroaryl)-thiazole-5-carboxamides as potent and orally active Src-family kinase p56(Lck) inhibitors. Bioorg Med Chem Lett. 2004 Dec 20;14(24):6061-6. DMOPUIH RU https://pubmed.ncbi.nlm.nih.gov/15546730 DMOPUIH DI DMOPUIH DMOPUIH DN PMID15546730C2 DMOPUIH MI TT6PKBN DMOPUIH MN Proto-oncogene c-Src (SRC) DMOPUIH MT DTT DMOPUIH MA Inhibitor DMOPUIH RN Discovery of novel 2-(aminoheteroaryl)-thiazole-5-carboxamides as potent and orally active Src-family kinase p56(Lck) inhibitors. Bioorg Med Chem Lett. 2004 Dec 20;14(24):6061-6. DMOPUIH RU https://pubmed.ncbi.nlm.nih.gov/15546730 DMOPUIH DI DMOPUIH DMOPUIH DN PMID15546730C2 DMOPUIH MI TTPOGS1 DMOPUIH MN Tyrosine-protein kinase Fgr (FGR) DMOPUIH MT DTT DMOPUIH MA Inhibitor DMOPUIH RN Discovery of novel 2-(aminoheteroaryl)-thiazole-5-carboxamides as potent and orally active Src-family kinase p56(Lck) inhibitors. Bioorg Med Chem Lett. 2004 Dec 20;14(24):6061-6. DMOPUIH RU https://pubmed.ncbi.nlm.nih.gov/15546730 DMN5LZQ DI DMN5LZQ DMN5LZQ DN PMID15603962Crac-16 DMN5LZQ MI TT7M9I6 DMN5LZQ MN Calcium-activated potassium channel KCa3.1 (KCNN4) DMN5LZQ MT DTT DMN5LZQ MA Blocker (channel blocker) DMN5LZQ RN IKCa-channel blockers. Part 2: discovery of cyclohexadienes. Bioorg Med Chem Lett. 2005 Jan 17;15(2):401-4. DMN5LZQ RU https://pubmed.ncbi.nlm.nih.gov/15603962 DM93RKC DI DM93RKC DM93RKC DN PMID15664838C18 DM93RKC MI TTJGLZF DM93RKC MN Dipeptidyl peptidase 8 (DPP-8) DM93RKC MT DTT DM93RKC MA Inhibitor DM93RKC RN Novel isoindoline compounds for potent and selective inhibition of prolyl dipeptidase DPP8. Bioorg Med Chem Lett. 2005 Feb 1;15(3):687-91. DM93RKC RU https://pubmed.ncbi.nlm.nih.gov/15664838 DM50E6R DI DM50E6R DM50E6R DN PMID15686906C17 DM50E6R MI TTPADOQ DM50E6R MN HMG-CoA reductase (HMGCR) DM50E6R MT DTT DM50E6R MA Inhibitor DM50E6R RN Three-dimensional quantitative structure (3-D QSAR) activity relationship studies on imidazolyl and N-pyrrolyl heptenoates as 3-hydroxy-3-methylglutaryl-CoA reductase (HMGR) inhibitors by comparativemolecular similarity indices analysis (CoMSIA). Bioorg Med Chem Lett. 2005 Feb 15;15(4):1027-32. DM50E6R RU https://pubmed.ncbi.nlm.nih.gov/15686906 DMBZSKJ DI DMBZSKJ DMBZSKJ DN PMID15686906C29 DMBZSKJ MI TTPADOQ DMBZSKJ MN HMG-CoA reductase (HMGCR) DMBZSKJ MT DTT DMBZSKJ MA Inhibitor DMBZSKJ RN Three-dimensional quantitative structure (3-D QSAR) activity relationship studies on imidazolyl and N-pyrrolyl heptenoates as 3-hydroxy-3-methylglutaryl-CoA reductase (HMGR) inhibitors by comparativemolecular similarity indices analysis (CoMSIA). Bioorg Med Chem Lett. 2005 Feb 15;15(4):1027-32. DMBZSKJ RU https://pubmed.ncbi.nlm.nih.gov/15686906 DMPB7Z6 DI DMPB7Z6 DMPB7Z6 DN PMID15686941C13 DMPB7Z6 MI TTHS256 DMPB7Z6 MN Metabotropic glutamate receptor 5 (mGluR5) DMPB7Z6 MT DTT DMPB7Z6 MA Modulator (allosteric modulator) DMPB7Z6 RN Dipyridyl amides: potent metabotropic glutamate subtype 5 (mGlu5) receptor antagonists. Bioorg Med Chem Lett. 2005 Feb 15;15(4):1197-200. DMPB7Z6 RU https://pubmed.ncbi.nlm.nih.gov/15686941 DMR7UBZ DI DMR7UBZ DMR7UBZ DN PMID15686947C(S)-3h DMR7UBZ MI TTBUYHA DMR7UBZ MN Extracellular calcium-sensing receptor (CASR) DMR7UBZ MT DTT DMR7UBZ MA Antagonist DMR7UBZ RN Discovery and structure-activity relationships of 2-benzylpyrrolidine-substituted aryloxypropanols as calcium-sensing receptor antagonists. Bioorg Med Chem Lett. 2005 Feb 15;15(4):1225-8. DMR7UBZ RU https://pubmed.ncbi.nlm.nih.gov/15686947 DMBEHA5 DI DMBEHA5 DMBEHA5 DN PMID15724976C1 DMBEHA5 MI TTVK7SB DMBEHA5 MN Histone acetyltransferase KAT2B (KAT2B) DMBEHA5 MT DTT DMBEHA5 MA Inhibitor DMBEHA5 RN Selective small molecules blocking HIV-1 Tat and coactivator PCAF association. J Am Chem Soc. 2005 Mar 2;127(8):2376-7. DMBEHA5 RU https://pubmed.ncbi.nlm.nih.gov/15724976 DMHY95J DI DMHY95J DMHY95J DN PMID15925511C13 DMHY95J MI TTU3WV6 DMHY95J MN SRSF protein kinase 1 (SRPK1) DMHY95J MT DTT DMHY95J MA Inhibitor DMHY95J RN Synthesis of selective SRPK-1 inhibitors: novel tricyclic quinoxaline derivatives. Bioorg Med Chem Lett. 2005 Jul 1;15(13):3241-6. DMHY95J RU https://pubmed.ncbi.nlm.nih.gov/15925511 DMF0ZXU DI DMF0ZXU DMF0ZXU DN PMID15955699C24 DMF0ZXU MI TTYXEPL DMF0ZXU MN Ribosomal protein S6 kinase alpha-5 (RSK5) DMF0ZXU MT DTT DMF0ZXU MA Inhibitor DMF0ZXU RN (1H-imidazo[4,5-c]pyridin-2-yl)-1,2,5-oxadiazol-3-ylamine derivatives: further optimisation as highly potent and selective MSK-1-inhibitors. Bioorg Med Chem Lett. 2005 Jul 15;15(14):3407-11. DMF0ZXU RU https://pubmed.ncbi.nlm.nih.gov/15955699 DMIRSWL DI DMIRSWL DMIRSWL DN PMID16099654C3a DMIRSWL MI TTVBPDM DMIRSWL MN Metabotropic glutamate receptor 1 (mGluR1) DMIRSWL MT DTT DMIRSWL MA Modulator (allosteric modulator) DMIRSWL RN 9H-Xanthene-9-carboxylic acid [1,2,4]oxadiazol-3-yl- and (2H-tetrazol-5-yl)-amides as potent, orally available mGlu1 receptor enhancers. Bioorg Med Chem Lett. 2005 Oct 15;15(20):4628-31. DMIRSWL RU https://pubmed.ncbi.nlm.nih.gov/16099654 DMV8UK1 DI DMV8UK1 DMV8UK1 DN PMID16099654C4b DMV8UK1 MI TTVBPDM DMV8UK1 MN Metabotropic glutamate receptor 1 (mGluR1) DMV8UK1 MT DTT DMV8UK1 MA Modulator (allosteric modulator) DMV8UK1 RN 9H-Xanthene-9-carboxylic acid [1,2,4]oxadiazol-3-yl- and (2H-tetrazol-5-yl)-amides as potent, orally available mGlu1 receptor enhancers. Bioorg Med Chem Lett. 2005 Oct 15;15(20):4628-31. DMV8UK1 RU https://pubmed.ncbi.nlm.nih.gov/16099654 DMM4A7P DI DMM4A7P DMM4A7P DN PMID16242323C15a DMM4A7P MI TTK3C21 DMM4A7P MN Acetoacetyl-CoA thiolase (ACAT1) DMM4A7P MT DTT DMM4A7P MA Inhibitor DMM4A7P RN Synthesis and biological activity of novel 4-phenyl-1,8-naphthyridin-2(1H)-on-3-yl ureas: potent acyl-CoA:cholesterol acyltransferase inhibitor wit... Bioorg Med Chem Lett. 2006 Jan 1;16(1):44-8. DMM4A7P RU https://pubmed.ncbi.nlm.nih.gov/16242323 DM7U3RM DI DM7U3RM DM7U3RM DN PMID16242323C15b DM7U3RM MI TTK3C21 DM7U3RM MN Acetoacetyl-CoA thiolase (ACAT1) DM7U3RM MT DTT DM7U3RM MA Inhibitor DM7U3RM RN Synthesis and biological activity of novel 4-phenyl-1,8-naphthyridin-2(1H)-on-3-yl ureas: potent acyl-CoA:cholesterol acyltransferase inhibitor wit... Bioorg Med Chem Lett. 2006 Jan 1;16(1):44-8. DM7U3RM RU https://pubmed.ncbi.nlm.nih.gov/16242323 DM2Q79X DI DM2Q79X DM2Q79X DN PMID16242323C16 DM2Q79X MI TTK3C21 DM2Q79X MN Acetoacetyl-CoA thiolase (ACAT1) DM2Q79X MT DTT DM2Q79X MA Inhibitor DM2Q79X RN Synthesis and biological activity of novel 4-phenyl-1,8-naphthyridin-2(1H)-on-3-yl ureas: potent acyl-CoA:cholesterol acyltransferase inhibitor wit... Bioorg Med Chem Lett. 2006 Jan 1;16(1):44-8. DM2Q79X RU https://pubmed.ncbi.nlm.nih.gov/16242323 DMI5WPQ DI DMI5WPQ DMI5WPQ DN PMID16242323C18a DMI5WPQ MI TTK3C21 DMI5WPQ MN Acetoacetyl-CoA thiolase (ACAT1) DMI5WPQ MT DTT DMI5WPQ MA Inhibitor DMI5WPQ RN Synthesis and biological activity of novel 4-phenyl-1,8-naphthyridin-2(1H)-on-3-yl ureas: potent acyl-CoA:cholesterol acyltransferase inhibitor wit... Bioorg Med Chem Lett. 2006 Jan 1;16(1):44-8. DMI5WPQ RU https://pubmed.ncbi.nlm.nih.gov/16242323 DMIS7NT DI DMIS7NT DMIS7NT DN PMID16242323C18b DMIS7NT MI TTK3C21 DMIS7NT MN Acetoacetyl-CoA thiolase (ACAT1) DMIS7NT MT DTT DMIS7NT MA Inhibitor DMIS7NT RN Synthesis and biological activity of novel 4-phenyl-1,8-naphthyridin-2(1H)-on-3-yl ureas: potent acyl-CoA:cholesterol acyltransferase inhibitor wit... Bioorg Med Chem Lett. 2006 Jan 1;16(1):44-8. DMIS7NT RU https://pubmed.ncbi.nlm.nih.gov/16242323 DMFDRMH DI DMFDRMH DMFDRMH DN PMID16242323C22c DMFDRMH MI TTK3C21 DMFDRMH MN Acetoacetyl-CoA thiolase (ACAT1) DMFDRMH MT DTT DMFDRMH MA Inhibitor DMFDRMH RN Synthesis and biological activity of novel 4-phenyl-1,8-naphthyridin-2(1H)-on-3-yl ureas: potent acyl-CoA:cholesterol acyltransferase inhibitor wit... Bioorg Med Chem Lett. 2006 Jan 1;16(1):44-8. DMFDRMH RU https://pubmed.ncbi.nlm.nih.gov/16242323 DMJICNL DI DMJICNL DMJICNL DN PMID16242323C22d DMJICNL MI TTK3C21 DMJICNL MN Acetoacetyl-CoA thiolase (ACAT1) DMJICNL MT DTT DMJICNL MA Inhibitor DMJICNL RN Synthesis and biological activity of novel 4-phenyl-1,8-naphthyridin-2(1H)-on-3-yl ureas: potent acyl-CoA:cholesterol acyltransferase inhibitor wit... Bioorg Med Chem Lett. 2006 Jan 1;16(1):44-8. DMJICNL RU https://pubmed.ncbi.nlm.nih.gov/16242323 DMD0Q7K DI DMD0Q7K DMD0Q7K DN PMID16242323C26a DMD0Q7K MI TTK3C21 DMD0Q7K MN Acetoacetyl-CoA thiolase (ACAT1) DMD0Q7K MT DTT DMD0Q7K MA Inhibitor DMD0Q7K RN Synthesis and biological activity of novel 4-phenyl-1,8-naphthyridin-2(1H)-on-3-yl ureas: potent acyl-CoA:cholesterol acyltransferase inhibitor wit... Bioorg Med Chem Lett. 2006 Jan 1;16(1):44-8. DMD0Q7K RU https://pubmed.ncbi.nlm.nih.gov/16242323 DMF0VLX DI DMF0VLX DMF0VLX DN PMID16242323C26b DMF0VLX MI TTK3C21 DMF0VLX MN Acetoacetyl-CoA thiolase (ACAT1) DMF0VLX MT DTT DMF0VLX MA Inhibitor DMF0VLX RN Synthesis and biological activity of novel 4-phenyl-1,8-naphthyridin-2(1H)-on-3-yl ureas: potent acyl-CoA:cholesterol acyltransferase inhibitor wit... Bioorg Med Chem Lett. 2006 Jan 1;16(1):44-8. DMF0VLX RU https://pubmed.ncbi.nlm.nih.gov/16242323 DMT3EU2 DI DMT3EU2 DMT3EU2 DN PMID16242323C26c DMT3EU2 MI TTK3C21 DMT3EU2 MN Acetoacetyl-CoA thiolase (ACAT1) DMT3EU2 MT DTT DMT3EU2 MA Inhibitor DMT3EU2 RN Synthesis and biological activity of novel 4-phenyl-1,8-naphthyridin-2(1H)-on-3-yl ureas: potent acyl-CoA:cholesterol acyltransferase inhibitor wit... Bioorg Med Chem Lett. 2006 Jan 1;16(1):44-8. DMT3EU2 RU https://pubmed.ncbi.nlm.nih.gov/16242323 DMIT4UN DI DMIT4UN DMIT4UN DN PMID16250654C37 DMIT4UN MI TTSCIUP DMIT4UN MN Oxytocin receptor (OTR) DMIT4UN MT DTT DMIT4UN MA Antagonist DMIT4UN RN 2,5-diketopiperazines as potent, selective, and orally bioavailable oxytocin antagonists. 2. Synthesis, chirality, and pharmacokinetics. J Med Chem. 2005 Nov 3;48(22):6956-69. DMIT4UN RU https://pubmed.ncbi.nlm.nih.gov/16250654 DMOP8YM DI DMOP8YM DMOP8YM DN PMID16290936C1b DMOP8YM MI TT3G406 DMOP8YM MN Cathepsin H (CTSH) DMOP8YM MT DTT DMOP8YM MA Inhibitor DMOP8YM RN Semicarbazone-based inhibitors of cathepsin K, are they prodrugs for aldehyde inhibitors Bioorg Med Chem Lett. 2006 Feb 15;16(4):978-83. DMOP8YM RU https://pubmed.ncbi.nlm.nih.gov/16290936 DMOP8YM DI DMOP8YM DMOP8YM DN PMID16290936C1b DMOP8YM MI TTDZN01 DMOP8YM MN Cathepsin K (CTSK) DMOP8YM MT DTT DMOP8YM MA Inhibitor DMOP8YM RN Semicarbazone-based inhibitors of cathepsin K, are they prodrugs for aldehyde inhibitors Bioorg Med Chem Lett. 2006 Feb 15;16(4):978-83. DMOP8YM RU https://pubmed.ncbi.nlm.nih.gov/16290936 DMI8HAV DI DMI8HAV DMI8HAV DN PMID16439120C20 DMI8HAV MI TTHS256 DMI8HAV MN Metabotropic glutamate receptor 5 (mGluR5) DMI8HAV MT DTT DMI8HAV MA Modulator (allosteric modulator) DMI8HAV RN Arylmethoxypyridines as novel, potent and orally active mGlu5 receptor antagonists. Bioorg Med Chem Lett. 2006 Apr 1;16(7):1892-7. DMI8HAV RU https://pubmed.ncbi.nlm.nih.gov/16439120 DMVM2XD DI DMVM2XD DMVM2XD DN PMID16439120C26 DMVM2XD MI TTHS256 DMVM2XD MN Metabotropic glutamate receptor 5 (mGluR5) DMVM2XD MT DTT DMVM2XD MA Modulator (allosteric modulator) DMVM2XD RN Arylmethoxypyridines as novel, potent and orally active mGlu5 receptor antagonists. Bioorg Med Chem Lett. 2006 Apr 1;16(7):1892-7. DMVM2XD RU https://pubmed.ncbi.nlm.nih.gov/16439120 DMT3RUE DI DMT3RUE DMT3RUE DN PMID16451062C46 DMT3RUE MI TT9RTBL DMT3RUE MN Aurora B messenger RNA (AURKB mRNA) DMT3RUE MT DTT DMT3RUE MA Inhibitor DMT3RUE RN Discovery of novel and potent thiazoloquinazolines as selective Aurora A and B kinase inhibitors. J Med Chem. 2006 Feb 9;49(3):955-70. DMT3RUE RU https://pubmed.ncbi.nlm.nih.gov/16451062 DMT3RUE DI DMT3RUE DMT3RUE DN PMID16451062C46 DMT3RUE MI TTLYXIT DMT3RUE MN Aurora kinase C (AURKC) DMT3RUE MT DTT DMT3RUE MA Inhibitor DMT3RUE RN Discovery of novel and potent thiazoloquinazolines as selective Aurora A and B kinase inhibitors. J Med Chem. 2006 Feb 9;49(3):955-70. DMT3RUE RU https://pubmed.ncbi.nlm.nih.gov/16451062 DM8BKI4 DI DM8BKI4 DM8BKI4 DN PMID16460935C28 DM8BKI4 MI TT7LRQH DM8BKI4 MN Complement C1s component (C1S) DM8BKI4 MT DTT DM8BKI4 MA Inhibitor DM8BKI4 RN A novel series of arylsulfonylthiophene-2-carboxamidine inhibitors of the complement component C1s. Bioorg Med Chem Lett. 2006 Apr 15;16(8):2200-4. DM8BKI4 RU https://pubmed.ncbi.nlm.nih.gov/16460935 DM2ZYR8 DI DM2ZYR8 DM2ZYR8 DN PMID16516466C12c DM2ZYR8 MI TTS2TEI DM2ZYR8 MN ADAM metallopeptidase with thrombospondin 1 (ADAMTS1) DM2ZYR8 MT DTT DM2ZYR8 MA Inhibitor DM2ZYR8 RN Synthesis and structure-activity relationship of a novel, achiral series of TNF-alpha converting enzyme inhibitors. Bioorg Med Chem Lett. 2006 May 15;16(10):2699-704. DM2ZYR8 RU https://pubmed.ncbi.nlm.nih.gov/16516466 DMU2X59 DI DMU2X59 DMU2X59 DN PMID16539403C15b DMU2X59 MI TTTUZ3O DMU2X59 MN MLK-related kinase (MLTK) DMU2X59 MT DTT DMU2X59 MA Inhibitor DMU2X59 RN Dihydropyrrolopyrazole transforming growth factor-beta type I receptor kinase domain inhibitors: a novel benzimidazole series with selectivity vers... J Med Chem. 2006 Mar 23;49(6):2138-42. DMU2X59 RU https://pubmed.ncbi.nlm.nih.gov/16539403 DMU2X59 DI DMU2X59 DMU2X59 DN PMID16539403C15b DMU2X59 MI TTP4520 DMU2X59 MN TGF-beta receptor type I (TGFBR1) DMU2X59 MT DTT DMU2X59 MA Inhibitor DMU2X59 RN Dihydropyrrolopyrazole transforming growth factor-beta type I receptor kinase domain inhibitors: a novel benzimidazole series with selectivity vers... J Med Chem. 2006 Mar 23;49(6):2138-42. DMU2X59 RU https://pubmed.ncbi.nlm.nih.gov/16539403 DMU2X59 DI DMU2X59 DMU2X59 DN PMID16539403C15b DMU2X59 MI TTZE3P7 DMU2X59 MN TGF-beta receptor type II (TGFBR2) DMU2X59 MT DTT DMU2X59 MA Inhibitor DMU2X59 RN Dihydropyrrolopyrazole transforming growth factor-beta type I receptor kinase domain inhibitors: a novel benzimidazole series with selectivity vers... J Med Chem. 2006 Mar 23;49(6):2138-42. DMU2X59 RU https://pubmed.ncbi.nlm.nih.gov/16539403 DMJ8A4I DI DMJ8A4I DMJ8A4I DN PMID1656041C11dd DMJ8A4I MI TTPADOQ DMJ8A4I MN HMG-CoA reductase (HMGCR) DMJ8A4I MT DTT DMJ8A4I MA Inhibitor DMJ8A4I RN Synthesis and biological activity of new HMG-CoA reductase inhibitors. 3. Lactones of 6-phenoxy-3,5-dihydroxyhexanoic acids. J Med Chem. 1991 Oct;34(10):2962-83. DMJ8A4I RU https://pubmed.ncbi.nlm.nih.gov/1656041 DM20TFH DI DM20TFH DM20TFH DN PMID1656041C11ff DM20TFH MI TTPADOQ DM20TFH MN HMG-CoA reductase (HMGCR) DM20TFH MT DTT DM20TFH MA Inhibitor DM20TFH RN Synthesis and biological activity of new HMG-CoA reductase inhibitors. 3. Lactones of 6-phenoxy-3,5-dihydroxyhexanoic acids. J Med Chem. 1991 Oct;34(10):2962-83. DM20TFH RU https://pubmed.ncbi.nlm.nih.gov/1656041 DMLIXJW DI DMLIXJW DMLIXJW DN PMID1656041C11jj DMLIXJW MI TTPADOQ DMLIXJW MN HMG-CoA reductase (HMGCR) DMLIXJW MT DTT DMLIXJW MA Inhibitor DMLIXJW RN Synthesis and biological activity of new HMG-CoA reductase inhibitors. 3. Lactones of 6-phenoxy-3,5-dihydroxyhexanoic acids. J Med Chem. 1991 Oct;34(10):2962-83. DMLIXJW RU https://pubmed.ncbi.nlm.nih.gov/1656041 DMNOMCT DI DMNOMCT DMNOMCT DN PMID1656041C11nn DMNOMCT MI TTPADOQ DMNOMCT MN HMG-CoA reductase (HMGCR) DMNOMCT MT DTT DMNOMCT MA Inhibitor DMNOMCT RN Synthesis and biological activity of new HMG-CoA reductase inhibitors. 3. Lactones of 6-phenoxy-3,5-dihydroxyhexanoic acids. J Med Chem. 1991 Oct;34(10):2962-83. DMNOMCT RU https://pubmed.ncbi.nlm.nih.gov/1656041 DMW90GD DI DMW90GD DMW90GD DN PMID1656041C4ff DMW90GD MI TTPADOQ DMW90GD MN HMG-CoA reductase (HMGCR) DMW90GD MT DTT DMW90GD MA Inhibitor DMW90GD RN Synthesis and biological activity of new HMG-CoA reductase inhibitors. 3. Lactones of 6-phenoxy-3,5-dihydroxyhexanoic acids. J Med Chem. 1991 Oct;34(10):2962-83. DMW90GD RU https://pubmed.ncbi.nlm.nih.gov/1656041 DMQGPJE DI DMQGPJE DMQGPJE DN PMID1656041C4rr DMQGPJE MI TTPADOQ DMQGPJE MN HMG-CoA reductase (HMGCR) DMQGPJE MT DTT DMQGPJE MA Inhibitor DMQGPJE RN Synthesis and biological activity of new HMG-CoA reductase inhibitors. 3. Lactones of 6-phenoxy-3,5-dihydroxyhexanoic acids. J Med Chem. 1991 Oct;34(10):2962-83. DMQGPJE RU https://pubmed.ncbi.nlm.nih.gov/1656041 DMZVK16 DI DMZVK16 DMZVK16 DN PMID1656041C74 DMZVK16 MI TTPADOQ DMZVK16 MN HMG-CoA reductase (HMGCR) DMZVK16 MT DTT DMZVK16 MA Inhibitor DMZVK16 RN Synthesis and biological activity of new HMG-CoA reductase inhibitors. 3. Lactones of 6-phenoxy-3,5-dihydroxyhexanoic acids. J Med Chem. 1991 Oct;34(10):2962-83. DMZVK16 RU https://pubmed.ncbi.nlm.nih.gov/1656041 DMITDEB DI DMITDEB DMITDEB DN PMID17064898C29 DMITDEB MI TTVBPDM DMITDEB MN Metabotropic glutamate receptor 1 (mGluR1) DMITDEB MT DTT DMITDEB MA Modulator (allosteric modulator) DMITDEB RN Structure-activity relationships of novel non-competitive mGluR1 antagonists: a potential treatment for chronic pain. Bioorg Med Chem Lett. 2007 Jan 15;17(2):486-90. DMITDEB RU https://pubmed.ncbi.nlm.nih.gov/17064898 DMLTXHJ DI DMLTXHJ DMLTXHJ DN PMID17125263C17 DMLTXHJ MI TTX4RTB DMLTXHJ MN Melanin-concentrating hormone receptor 1 (MCHR1) DMLTXHJ MT DTT DMLTXHJ MA Antagonist DMLTXHJ RN 6-(4-chlorophenyl)-3-substituted-thieno[3,2-d]pyrimidin-4(3H)-one-based melanin-concentrating hormone receptor 1 antagonist. J Med Chem. 2006 Nov 30;49(24):7108-18. DMLTXHJ RU https://pubmed.ncbi.nlm.nih.gov/17125263 DMG9ZYP DI DMG9ZYP DMG9ZYP DN PMID17189691C42 DMG9ZYP MI TTHS256 DMG9ZYP MN Metabotropic glutamate receptor 5 (mGluR5) DMG9ZYP MT DTT DMG9ZYP MA Modulator (allosteric modulator) DMG9ZYP RN Rational design, synthesis, and structure-activity relationship of benzoxazolones: new potent mglu5 receptor antagonists based on the fenobam struc... Bioorg Med Chem Lett. 2007 Mar 1;17(5):1302-6. DMG9ZYP RU https://pubmed.ncbi.nlm.nih.gov/17189691 DMWNYBV DI DMWNYBV DMWNYBV DN PMID17276684C22 DMWNYBV MI TTVBPDM DMWNYBV MN Metabotropic glutamate receptor 1 (mGluR1) DMWNYBV MT DTT DMWNYBV MA Modulator (allosteric modulator) DMWNYBV RN From pyrroles to 1-oxo-2,3,4,9-tetrahydro-1H-beta-carbolines: a new class of orally bioavailable mGluR1 antagonists. Bioorg Med Chem Lett. 2007 Apr 15;17(8):2254-9. DMWNYBV RU https://pubmed.ncbi.nlm.nih.gov/17276684 DMXHS4L DI DMXHS4L DMXHS4L DN PMID17280833C30 DMXHS4L MI TTIET93 DMXHS4L MN Activated CDC42 kinase 1 (ACK-1) DMXHS4L MT DTT DMXHS4L MA Inhibitor DMXHS4L RN Discovery of 4-amino-5,6-biaryl-furo[2,3-d]pyrimidines as inhibitors of Lck: development of an expedient and divergent synthetic route and prelimin... Bioorg Med Chem Lett. 2007 Apr 15;17(8):2305-9. DMXHS4L RU https://pubmed.ncbi.nlm.nih.gov/17280833 DMXHS4L DI DMXHS4L DMXHS4L DN PMID17280833C30 DMXHS4L MI TT860QF DMXHS4L MN LCK tyrosine protein kinase (LCK) DMXHS4L MT DTT DMXHS4L MA Inhibitor DMXHS4L RN Discovery of 4-amino-5,6-biaryl-furo[2,3-d]pyrimidines as inhibitors of Lck: development of an expedient and divergent synthetic route and prelimin... Bioorg Med Chem Lett. 2007 Apr 15;17(8):2305-9. DMXHS4L RU https://pubmed.ncbi.nlm.nih.gov/17280833 DMR9TYV DI DMR9TYV DMR9TYV DN PMID17358052C5b DMR9TYV MI TT8WFXV DMR9TYV MN Hydroxycarboxylic acid receptor 3 (HCAR3) DMR9TYV MT DTT DMR9TYV MA Agonist DMR9TYV RN Analogues of acifran: agonists of the high and low affinity niacin receptors, GPR109a and GPR109b. J Med Chem. 2007 Apr 5;50(7):1445-8. DMR9TYV RU https://pubmed.ncbi.nlm.nih.gov/17358052 DM4BZ2L DI DM4BZ2L DM4BZ2L DN PMID1738140C9 DM4BZ2L MI TTGMFY7 DM4BZ2L MN Aspartyl aminopeptidase (DNPEP) DM4BZ2L MT DTT DM4BZ2L MA Inhibitor DM4BZ2L RN Alpha-Keto amide inhibitors of aminopeptidases. J Med Chem. 1992 Feb 7;35(3):451-6. DM4BZ2L RU https://pubmed.ncbi.nlm.nih.gov/1738140 DM4IABG DI DM4IABG DM4IABG DN PMID17480064C16 DM4IABG MI TTMUG9D DM4IABG MN MAPK-activated protein kinase 2 (MAPKAPK2) DM4IABG MT DTT DM4IABG MA Inhibitor DM4IABG RN Pyrrolopyridine inhibitors of mitogen-activated protein kinase-activated protein kinase 2 (MK-2). J Med Chem. 2007 May 31;50(11):2647-54. DM4IABG RU https://pubmed.ncbi.nlm.nih.gov/17480064 DM4IABG DI DM4IABG DM4IABG DN PMID17480064C16 DM4IABG MI TTFS4VU DM4IABG MN MAPK-activated protein kinase 3 (MAPKAPK3) DM4IABG MT DTT DM4IABG MA Inhibitor DM4IABG RN Pyrrolopyridine inhibitors of mitogen-activated protein kinase-activated protein kinase 2 (MK-2). J Med Chem. 2007 May 31;50(11):2647-54. DM4IABG RU https://pubmed.ncbi.nlm.nih.gov/17480064 DM4IABG DI DM4IABG DM4IABG DN PMID17480064C16 DM4IABG MI TT3UJ7Z DM4IABG MN MAPK-activated protein kinase 5 (MAPKAPK5) DM4IABG MT DTT DM4IABG MA Inhibitor DM4IABG RN Pyrrolopyridine inhibitors of mitogen-activated protein kinase-activated protein kinase 2 (MK-2). J Med Chem. 2007 May 31;50(11):2647-54. DM4IABG RU https://pubmed.ncbi.nlm.nih.gov/17480064 DMX3CYG DI DMX3CYG DMX3CYG DN PMID17532216C2f DMX3CYG MI TTVBPDM DMX3CYG MN Metabotropic glutamate receptor 1 (mGluR1) DMX3CYG MT DTT DMX3CYG MA Modulator (allosteric modulator) DMX3CYG RN Rapid hit to lead evaluation of pyrazolo[3,4-d]pyrimidin-4-one as selective and orally bioavailable mGluR1 antagonists. Bioorg Med Chem Lett. 2007 Aug 1;17(15):4303-7. DMX3CYG RU https://pubmed.ncbi.nlm.nih.gov/17532216 DM7Z2WV DI DM7Z2WV DM7Z2WV DN PMID17556356C1a DM7Z2WV MI TTPNQAC DM7Z2WV MN Estrogen-related receptor-alpha (ESRRA) DM7Z2WV MT DTT DM7Z2WV MA Antagonist DM7Z2WV RN Crystal structure of human estrogen-related receptor alpha in complex with a synthetic inverse agonist reveals its novel molecular mechanism. J Biol Chem. 2007 Aug 10;282(32):23231-9. DM7Z2WV RU https://pubmed.ncbi.nlm.nih.gov/17556356 DMLX87P DI DMLX87P DMLX87P DN PMID17560788C29f DMLX87P MI TTPADOQ DMLX87P MN HMG-CoA reductase (HMGCR) DMLX87P MT DTT DMLX87P MA Inhibitor DMLX87P RN Discovery of pyrrole-based hepatoselective ligands as potent inhibitors of HMG-CoA reductase. Bioorg Med Chem. 2007 Aug 15;15(16):5576-89. DMLX87P RU https://pubmed.ncbi.nlm.nih.gov/17560788 DM6W73A DI DM6W73A DM6W73A DN PMID17574411C41 DM6W73A MI TTPADOQ DM6W73A MN HMG-CoA reductase (HMGCR) DM6W73A MT DTT DM6W73A MA Inhibitor DM6W73A RN Design and synthesis of novel, conformationally restricted HMG-CoA reductase inhibitors. Bioorg Med Chem Lett. 2007 Aug 15;17(16):4531-7. DM6W73A RU https://pubmed.ncbi.nlm.nih.gov/17574411 DM1YLF6 DI DM1YLF6 DM1YLF6 DN PMID17574411C42 DM1YLF6 MI TTPADOQ DM1YLF6 MN HMG-CoA reductase (HMGCR) DM1YLF6 MT DTT DM1YLF6 MA Inhibitor DM1YLF6 RN Design and synthesis of novel, conformationally restricted HMG-CoA reductase inhibitors. Bioorg Med Chem Lett. 2007 Aug 15;17(16):4531-7. DM1YLF6 RU https://pubmed.ncbi.nlm.nih.gov/17574411 DM7HYPZ DI DM7HYPZ DM7HYPZ DN PMID17574412C33 DM7HYPZ MI TTPADOQ DM7HYPZ MN HMG-CoA reductase (HMGCR) DM7HYPZ MT DTT DM7HYPZ MA Inhibitor DM7HYPZ RN Design and synthesis of hepatoselective, pyrrole-based HMG-CoA reductase inhibitors. Bioorg Med Chem Lett. 2007 Aug 15;17(16):4538-44. DM7HYPZ RU https://pubmed.ncbi.nlm.nih.gov/17574412 DMJFOGW DI DMJFOGW DMJFOGW DN PMID17600705C23 DMJFOGW MI TT860QF DMJFOGW MN LCK tyrosine protein kinase (LCK) DMJFOGW MT DTT DMJFOGW MA Inhibitor DMJFOGW RN N-4-Pyrimidinyl-1H-indazol-4-amine inhibitors of Lck: indazoles as phenol isosteres with improved pharmacokinetics. Bioorg Med Chem Lett. 2007 Aug 1;17(15):4363-8. DMJFOGW RU https://pubmed.ncbi.nlm.nih.gov/17600705 DMJFOGW DI DMJFOGW DMJFOGW DN PMID17600705C23 DMJFOGW MI TT1RWNJ DMJFOGW MN Tyrosine-protein kinase Lyn (JTK8) DMJFOGW MT DTT DMJFOGW MA Inhibitor DMJFOGW RN N-4-Pyrimidinyl-1H-indazol-4-amine inhibitors of Lck: indazoles as phenol isosteres with improved pharmacokinetics. Bioorg Med Chem Lett. 2007 Aug 1;17(15):4363-8. DMJFOGW RU https://pubmed.ncbi.nlm.nih.gov/17600705 DMJFOGW DI DMJFOGW DMJFOGW DN PMID17600705C23 DMJFOGW MI TTOU65C DMJFOGW MN Tyrosine-protein kinase SYK (SYK) DMJFOGW MT DTT DMJFOGW MA Inhibitor DMJFOGW RN N-4-Pyrimidinyl-1H-indazol-4-amine inhibitors of Lck: indazoles as phenol isosteres with improved pharmacokinetics. Bioorg Med Chem Lett. 2007 Aug 1;17(15):4363-8. DMJFOGW RU https://pubmed.ncbi.nlm.nih.gov/17600705 DMJFOGW DI DMJFOGW DMJFOGW DN PMID17600705C23 DMJFOGW MI TT8M1DP DMJFOGW MN Tyrosine-protein kinase TXK (TXK) DMJFOGW MT DTT DMJFOGW MA Inhibitor DMJFOGW RN N-4-Pyrimidinyl-1H-indazol-4-amine inhibitors of Lck: indazoles as phenol isosteres with improved pharmacokinetics. Bioorg Med Chem Lett. 2007 Aug 1;17(15):4363-8. DMJFOGW RU https://pubmed.ncbi.nlm.nih.gov/17600705 DMMB6NU DI DMMB6NU DMMB6NU DN PMID17709461C4g DMMB6NU MI TTFQEO5 DMMB6NU MN Squalene synthetase (FDFT1) DMMB6NU MT DTT DMMB6NU MA Inhibitor DMMB6NU RN Quinuclidine derivatives as potential antiparasitics. Antimicrob Agents Chemother. 2007 Nov;51(11):4049-61. DMMB6NU RU https://pubmed.ncbi.nlm.nih.gov/17709461 DMBP3O7 DI DMBP3O7 DMBP3O7 DN PMID17723296C18 DMBP3O7 MI TTHS256 DMBP3O7 MN Metabotropic glutamate receptor 5 (mGluR5) DMBP3O7 MT DTT DMBP3O7 MA Modulator (allosteric modulator) DMBP3O7 RN Synthesis and SAR of 2-aryl pyrido[2,3-d]pyrimidines as potent mGlu5 receptor antagonists. Bioorg Med Chem Lett. 2007 Oct 1;17(19):5396-9. DMBP3O7 RU https://pubmed.ncbi.nlm.nih.gov/17723296 DMLPC17 DI DMLPC17 DMLPC17 DN PMID17888661C18 DMLPC17 MI TTE5J6X DMLPC17 MN Diphosphomevalonate decarboxylase (MVD) DMLPC17 MT DTT DMLPC17 MA Inhibitor DMLPC17 RN Mutation and inhibition studies of mevalonate 5-diphosphate decarboxylase. Bioorg Med Chem Lett. 2007 Nov 15;17(22):6164-8. DMLPC17 RU https://pubmed.ncbi.nlm.nih.gov/17888661 DMRWTHA DI DMRWTHA DMRWTHA DN PMID17888661C19 DMRWTHA MI TTE5J6X DMRWTHA MN Diphosphomevalonate decarboxylase (MVD) DMRWTHA MT DTT DMRWTHA MA Inhibitor DMRWTHA RN Mutation and inhibition studies of mevalonate 5-diphosphate decarboxylase. Bioorg Med Chem Lett. 2007 Nov 15;17(22):6164-8. DMRWTHA RU https://pubmed.ncbi.nlm.nih.gov/17888661 DMDVW4K DI DMDVW4K DMDVW4K DN PMID17929793C11c DMDVW4K MI TTVBPDM DMDVW4K MN Metabotropic glutamate receptor 1 (mGluR1) DMDVW4K MT DTT DMDVW4K MA Modulator (allosteric modulator) DMDVW4K RN Discovery of orally efficacious tetracyclic metabotropic glutamate receptor 1 (mGluR1) antagonists for the treatment of chronic pain. J Med Chem. 2007 Nov 15;50(23):5550-3. DMDVW4K RU https://pubmed.ncbi.nlm.nih.gov/17929793 DMIG308 DI DMIG308 DMIG308 DN PMID17929793C23c DMIG308 MI TTVBPDM DMIG308 MN Metabotropic glutamate receptor 1 (mGluR1) DMIG308 MT DTT DMIG308 MA Modulator (allosteric modulator) DMIG308 RN Discovery of orally efficacious tetracyclic metabotropic glutamate receptor 1 (mGluR1) antagonists for the treatment of chronic pain. J Med Chem. 2007 Nov 15;50(23):5550-3. DMIG308 RU https://pubmed.ncbi.nlm.nih.gov/17929793 DMOB07W DI DMOB07W DMOB07W DN PMID17929793C23e DMOB07W MI TTVBPDM DMOB07W MN Metabotropic glutamate receptor 1 (mGluR1) DMOB07W MT DTT DMOB07W MA Modulator (allosteric modulator) DMOB07W RN Discovery of orally efficacious tetracyclic metabotropic glutamate receptor 1 (mGluR1) antagonists for the treatment of chronic pain. J Med Chem. 2007 Nov 15;50(23):5550-3. DMOB07W RU https://pubmed.ncbi.nlm.nih.gov/17929793 DM83Z6M DI DM83Z6M DM83Z6M DN PMID17929793C23h DM83Z6M MI TTVBPDM DM83Z6M MN Metabotropic glutamate receptor 1 (mGluR1) DM83Z6M MT DTT DM83Z6M MA Modulator (allosteric modulator) DM83Z6M RN Discovery of orally efficacious tetracyclic metabotropic glutamate receptor 1 (mGluR1) antagonists for the treatment of chronic pain. J Med Chem. 2007 Nov 15;50(23):5550-3. DM83Z6M RU https://pubmed.ncbi.nlm.nih.gov/17929793 DM07TVS DI DM07TVS DM07TVS DN PMID17929793C23i DM07TVS MI TTVBPDM DM07TVS MN Metabotropic glutamate receptor 1 (mGluR1) DM07TVS MT DTT DM07TVS MA Modulator (allosteric modulator) DM07TVS RN Discovery of orally efficacious tetracyclic metabotropic glutamate receptor 1 (mGluR1) antagonists for the treatment of chronic pain. J Med Chem. 2007 Nov 15;50(23):5550-3. DM07TVS RU https://pubmed.ncbi.nlm.nih.gov/17929793 DML8ZBR DI DML8ZBR DML8ZBR DN PMID17935989C25 DML8ZBR MI TTTU902 DML8ZBR MN Checkpoint kinase-1 (CHK1) DML8ZBR MT DTT DML8ZBR MA Inhibitor DML8ZBR RN Macrocyclic ureas as potent and selective Chk1 inhibitors: an improved synthesis, kinome profiling, structure-activity relationships, and prelimina... Bioorg Med Chem Lett. 2007 Dec 1;17(23):6593-601. DML8ZBR RU https://pubmed.ncbi.nlm.nih.gov/17935989 DML8ZBR DI DML8ZBR DML8ZBR DN PMID17935989C25 DML8ZBR MI TT6SA0X DML8ZBR MN Muscle-specific kinase receptor (MUSK) DML8ZBR MT DTT DML8ZBR MA Inhibitor DML8ZBR RN Macrocyclic ureas as potent and selective Chk1 inhibitors: an improved synthesis, kinome profiling, structure-activity relationships, and prelimina... Bioorg Med Chem Lett. 2007 Dec 1;17(23):6593-601. DML8ZBR RU https://pubmed.ncbi.nlm.nih.gov/17935989 DML8ZBR DI DML8ZBR DML8ZBR DN PMID17935989C25 DML8ZBR MI TT1VAUK DML8ZBR MN VEGFR1 messenger RNA (VEGFR1 mRNA) DML8ZBR MT DTT DML8ZBR MA Inhibitor DML8ZBR RN Macrocyclic ureas as potent and selective Chk1 inhibitors: an improved synthesis, kinome profiling, structure-activity relationships, and prelimina... Bioorg Med Chem Lett. 2007 Dec 1;17(23):6593-601. DML8ZBR RU https://pubmed.ncbi.nlm.nih.gov/17935989 DMEHC2I DI DMEHC2I DMEHC2I DN PMID17936624C36 DMEHC2I MI TTHS256 DMEHC2I MN Metabotropic glutamate receptor 5 (mGluR5) DMEHC2I MT DTT DMEHC2I MA Modulator (allosteric modulator) DMEHC2I RN Synthesis and SAR comparison of regioisomeric aryl naphthyridines as potent mGlu5 receptor antagonists. Bioorg Med Chem Lett. 2007 Dec 1;17(23):6525-8. DMEHC2I RU https://pubmed.ncbi.nlm.nih.gov/17936624 DMYH36T DI DMYH36T DMYH36T DN PMID17942791C3 DMYH36T MI TT2AP5B DMYH36T MN Ras converting CAAX endopeptidase 1 (RCE1) DMYH36T MT DTT DMYH36T MA Inhibitor DMYH36T RN Small-molecule inhibitors of the Rce1p CaaX protease. J Biomol Screen. 2007 Oct;12(7):983-93. DMYH36T RU https://pubmed.ncbi.nlm.nih.gov/17942791 DMTP5OY DI DMTP5OY DMTP5OY DN PMID17963374C31 DMTP5OY MI TTIKWV4 DMTP5OY MN Geranyltranstransferase (FDPS) DMTP5OY MT DTT DMTP5OY MA Inhibitor DMTP5OY RN Activity of sulfonium bisphosphonates on tumor cell lines. J Med Chem. 2007 Nov 29;50(24):6067-79. DMTP5OY RU https://pubmed.ncbi.nlm.nih.gov/17963374 DMS1QM8 DI DMS1QM8 DMS1QM8 DN PMID17975902C5e DMS1QM8 MI TTIKWV4 DMS1QM8 MN Geranyltranstransferase (FDPS) DMS1QM8 MT DTT DMS1QM8 MA Inhibitor DMS1QM8 RN Synthesis and biological evaluation of alpha-halogenated bisphosphonate and phosphonocarboxylate analogues of risedronate. J Med Chem. 2007 Nov 29;50(24):5967-75. DMS1QM8 RU https://pubmed.ncbi.nlm.nih.gov/17975902 DMTZQUJ DI DMTZQUJ DMTZQUJ DN PMID18068976C25 DMTZQUJ MI TTVXEGU DMTZQUJ MN ADAM10 messenger RNA (ADAM10 mRNA) DMTZQUJ MT DTT DMTZQUJ MA Inhibitor DMTZQUJ RN Conversion of an MMP-potent scaffold to an MMP-selective HER-2 sheddase inhibitor via scaffold hybridization and subtle P1' permutations. Bioorg Med Chem Lett. 2008 Jan 15;18(2):560-4. DMTZQUJ RU https://pubmed.ncbi.nlm.nih.gov/18068976 DMK5PO8 DI DMK5PO8 DMK5PO8 DN PMID18072721C50 DMK5PO8 MI TTPADOQ DMK5PO8 MN HMG-CoA reductase (HMGCR) DMK5PO8 MT DTT DMK5PO8 MA Inhibitor DMK5PO8 RN Substituted pyrazoles as hepatoselective HMG-CoA reductase inhibitors: discovery of (3R,5R)-7-[2-(4-fluoro-phenyl)-4-isopropyl-5-(4-methyl-benzylca... J Med Chem. 2008 Jan 10;51(1):31-45. DMK5PO8 RU https://pubmed.ncbi.nlm.nih.gov/18072721 DMO21H5 DI DMO21H5 DMO21H5 DN PMID18078750C1b DMO21H5 MI TT3LJ6G DMO21H5 MN Carboxypeptidase A1 (CPA1) DMO21H5 MT DTT DMO21H5 MA Inhibitor DMO21H5 RN Thiol-based angiotensin-converting enzyme 2 inhibitors: P1 modifications for the exploration of the S1 subsite. Bioorg Med Chem Lett. 2008 Jan 15;18(2):732-7. DMO21H5 RU https://pubmed.ncbi.nlm.nih.gov/18078750 DMO21H5 DI DMO21H5 DMO21H5 DN PMID18078750C1b DMO21H5 MI TT5TKPM DMO21H5 MN Neutral endopeptidase (MME) DMO21H5 MT DTT DMO21H5 MA Inhibitor DMO21H5 RN Thiol-based angiotensin-converting enzyme 2 inhibitors: P1 modifications for the exploration of the S1 subsite. Bioorg Med Chem Lett. 2008 Jan 15;18(2):732-7. DMO21H5 RU https://pubmed.ncbi.nlm.nih.gov/18078750 DM2U4NW DI DM2U4NW DM2U4NW DN PMID18155906C16f DM2U4NW MI TTPADOQ DM2U4NW MN HMG-CoA reductase (HMGCR) DM2U4NW MT DTT DM2U4NW MA Inhibitor DM2U4NW RN Hepatoselectivity of statins: design and synthesis of 4-sulfamoyl pyrroles as HMG-CoA reductase inhibitors. Bioorg Med Chem Lett. 2008 Feb 1;18(3):1151-6. DM2U4NW RU https://pubmed.ncbi.nlm.nih.gov/18155906 DMA2OWK DI DMA2OWK DMA2OWK DN PMID18178086C15 DMA2OWK MI TTB7Y8I DMA2OWK MN Lysophosphatidic acid receptor 2 (LPAR2) DMA2OWK MT DTT DMA2OWK MA Antagonist DMA2OWK RN Discovery of potent LPA2 (EDG4) antagonists as potential anticancer agents. Bioorg Med Chem Lett. 2008 Feb 1;18(3):1037-41. DMA2OWK RU https://pubmed.ncbi.nlm.nih.gov/18178086 DM3GYNM DI DM3GYNM DM3GYNM DN PMID18295483C2 DM3GYNM MI TTIKWV4 DM3GYNM MN Geranyltranstransferase (FDPS) DM3GYNM MT DTT DM3GYNM MA Inhibitor DM3GYNM RN Design and structure-activity relationships of potent and selective inhibitors of undecaprenyl pyrophosphate synthase (UPPS): tetramic, tetronic acids and dihydropyridin-2-ones. Bioorg Med Chem Lett.2008 Mar 15;18(6):1840-4. DM3GYNM RU https://pubmed.ncbi.nlm.nih.gov/18295483 DMCTFWE DI DMCTFWE DMCTFWE DN PMID18324760C28 DMCTFWE MI TTUI5H7 DMCTFWE MN Angiotensin-converting enzyme 2 (ACE2) DMCTFWE MT DTT DMCTFWE MA Inhibitor DMCTFWE RN Development of potent and selective phosphinic peptide inhibitors of angiotensin-converting enzyme 2. J Med Chem. 2008 Apr 10;51(7):2216-26. DMCTFWE RU https://pubmed.ncbi.nlm.nih.gov/18324760 DM1I6AY DI DM1I6AY DM1I6AY DN PMID18334293C15b DM1I6AY MI TTFYL58 DM1I6AY MN CaM-kinase II (CAMK2) DM1I6AY MT DTT DM1I6AY MA Inhibitor DM1I6AY RN Pyrimidine-based inhibitors of CaMKIIdelta. Bioorg Med Chem Lett. 2008 Apr 1;18(7):2404-8. DM1I6AY RU https://pubmed.ncbi.nlm.nih.gov/18334293 DMEOHLV DI DMEOHLV DMEOHLV DN PMID18337095C27 DMEOHLV MI TTFYL58 DMEOHLV MN CaM-kinase II (CAMK2) DMEOHLV MT DTT DMEOHLV MA Inhibitor DMEOHLV RN Aryl-indolyl maleimides as inhibitors of CaMKIIdelta. Part 3: Importance of the indole orientation. Bioorg Med Chem Lett. 2008 Apr 1;18(7):2399-403. DMEOHLV RU https://pubmed.ncbi.nlm.nih.gov/18337095 DM6NL2B DI DM6NL2B DM6NL2B DN PMID18412317C13b DM6NL2B MI TTPADOQ DM6NL2B MN HMG-CoA reductase (HMGCR) DM6NL2B MT DTT DM6NL2B MA Inhibitor DM6NL2B RN (3R,5S,E)-7-(4-(4-fluorophenyl)-6-isopropyl-2-(methyl(1-methyl-1h-1,2,4-triazol-5-yl)amino)pyrimidin-5-yl)-3,5-dihydroxyhept-6-enoic acid (BMS-644950): a rationally designed orally efficacious 3-hydroxy-3-methylglutaryl coenzyme-a reductase inhibitor with reduced myotoxicity potential. J Med Chem. 2008 May 8;51(9):2722-33. DM6NL2B RU https://pubmed.ncbi.nlm.nih.gov/18412317 DMW7PQ8 DI DMW7PQ8 DMW7PQ8 DN PMID18445527C11 DMW7PQ8 MI TTA93TL DMW7PQ8 MN P2Y purinoceptor 1 (P2RY1) DMW7PQ8 MT DTT DMW7PQ8 MA Antagonist DMW7PQ8 RN P2Y1 receptor antagonists as novel antithrombotic agents. Bioorg Med Chem Lett. 2008 Jun 1;18(11):3338-43. DMW7PQ8 RU https://pubmed.ncbi.nlm.nih.gov/18445527 DM7AXRF DI DM7AXRF DM7AXRF DN PMID18445527C67 DM7AXRF MI TTA93TL DM7AXRF MN P2Y purinoceptor 1 (P2RY1) DM7AXRF MT DTT DM7AXRF MA Antagonist DM7AXRF RN P2Y1 receptor antagonists as novel antithrombotic agents. Bioorg Med Chem Lett. 2008 Jun 1;18(11):3338-43. DM7AXRF RU https://pubmed.ncbi.nlm.nih.gov/18445527 DM0G42B DI DM0G42B DM0G42B DN PMID18477808CB DM0G42B MI TTB8FUC DM0G42B MN Free fatty acid receptor 1 (GPR40) DM0G42B MT DTT DM0G42B MA Agonist DM0G42B RN Selective small-molecule agonists of G protein-coupled receptor 40 promote glucose-dependent insulin secretion and reduce blood glucose in mice. Diabetes. 2008 Aug;57(8):2211-9. DM0G42B RU https://pubmed.ncbi.nlm.nih.gov/18477808 DMPZSGV DI DMPZSGV DMPZSGV DN PMID18752940C9n DMPZSGV MI TTWNV8U DMPZSGV MN Nicotinic acid receptor (HCAR2) DMPZSGV MT DTT DMPZSGV MA Modulator (allosteric modulator) DMPZSGV RN Discovery of pyrazolopyrimidines as the first class of allosteric agonists for the high affinity nicotinic acid receptor GPR109A. Bioorg Med Chem Lett. 2008 Sep 15;18(18):4948-51. DMPZSGV RU https://pubmed.ncbi.nlm.nih.gov/18752940 DMTH0PD DI DMTH0PD DMTH0PD DN PMID1875346C18 DMTH0PD MI TTPADOQ DMTH0PD MN HMG-CoA reductase (HMGCR) DMTH0PD MT DTT DMTH0PD MA Inhibitor DMTH0PD RN 3-Hydroxy-3-methylglutaryl-coenzyme a reductase inhibitors. 7. Modification of the hexahydronaphthalene moiety of simvastatin: 5-oxygenated and 5-oxa derivatives. J Med Chem. 1991 Aug;34(8):2489-95. DMTH0PD RU https://pubmed.ncbi.nlm.nih.gov/1875346 DM1JRGI DI DM1JRGI DM1JRGI DN PMID18754614C10 DM1JRGI MI TTFQEO5 DM1JRGI MN Squalene synthetase (FDFT1) DM1JRGI MT DTT DM1JRGI MA Inhibitor DM1JRGI RN Lipid-lowering (hetero)aromatic tetrahydro-1,4-oxazine derivatives with antioxidant and squalene synthase inhibitory activity. J Med Chem. 2008 Sep 25;51(18):5861-5. DM1JRGI RU https://pubmed.ncbi.nlm.nih.gov/18754614 DMSVB9D DI DMSVB9D DMSVB9D DN PMID18754614C17 DMSVB9D MI TTFQEO5 DMSVB9D MN Squalene synthetase (FDFT1) DMSVB9D MT DTT DMSVB9D MA Inhibitor DMSVB9D RN Lipid-lowering (hetero)aromatic tetrahydro-1,4-oxazine derivatives with antioxidant and squalene synthase inhibitory activity. J Med Chem. 2008 Sep 25;51(18):5861-5. DMSVB9D RU https://pubmed.ncbi.nlm.nih.gov/18754614 DMF7VZO DI DMF7VZO DMF7VZO DN PMID18754614C18 DMF7VZO MI TTFQEO5 DMF7VZO MN Squalene synthetase (FDFT1) DMF7VZO MT DTT DMF7VZO MA Inhibitor DMF7VZO RN Lipid-lowering (hetero)aromatic tetrahydro-1,4-oxazine derivatives with antioxidant and squalene synthase inhibitory activity. J Med Chem. 2008 Sep 25;51(18):5861-5. DMF7VZO RU https://pubmed.ncbi.nlm.nih.gov/18754614 DMHSE96 DI DMHSE96 DMHSE96 DN PMID18754614C19 DMHSE96 MI TTFQEO5 DMHSE96 MN Squalene synthetase (FDFT1) DMHSE96 MT DTT DMHSE96 MA Inhibitor DMHSE96 RN Lipid-lowering (hetero)aromatic tetrahydro-1,4-oxazine derivatives with antioxidant and squalene synthase inhibitory activity. J Med Chem. 2008 Sep 25;51(18):5861-5. DMHSE96 RU https://pubmed.ncbi.nlm.nih.gov/18754614 DMQFYM4 DI DMQFYM4 DMQFYM4 DN PMID18754614C4 DMQFYM4 MI TTFQEO5 DMQFYM4 MN Squalene synthetase (FDFT1) DMQFYM4 MT DTT DMQFYM4 MA Inhibitor DMQFYM4 RN Lipid-lowering (hetero)aromatic tetrahydro-1,4-oxazine derivatives with antioxidant and squalene synthase inhibitory activity. J Med Chem. 2008 Sep 25;51(18):5861-5. DMQFYM4 RU https://pubmed.ncbi.nlm.nih.gov/18754614 DMVTLO0 DI DMVTLO0 DMVTLO0 DN PMID18754614C7 DMVTLO0 MI TTFQEO5 DMVTLO0 MN Squalene synthetase (FDFT1) DMVTLO0 MT DTT DMVTLO0 MA Inhibitor DMVTLO0 RN Lipid-lowering (hetero)aromatic tetrahydro-1,4-oxazine derivatives with antioxidant and squalene synthase inhibitory activity. J Med Chem. 2008 Sep 25;51(18):5861-5. DMVTLO0 RU https://pubmed.ncbi.nlm.nih.gov/18754614 DM7SCM3 DI DM7SCM3 DM7SCM3 DN PMID18754614C8 DM7SCM3 MI TTFQEO5 DM7SCM3 MN Squalene synthetase (FDFT1) DM7SCM3 MT DTT DM7SCM3 MA Inhibitor DM7SCM3 RN Lipid-lowering (hetero)aromatic tetrahydro-1,4-oxazine derivatives with antioxidant and squalene synthase inhibitory activity. J Med Chem. 2008 Sep 25;51(18):5861-5. DM7SCM3 RU https://pubmed.ncbi.nlm.nih.gov/18754614 DMPH7A6 DI DMPH7A6 DMPH7A6 DN PMID18754614C9 DMPH7A6 MI TTFQEO5 DMPH7A6 MN Squalene synthetase (FDFT1) DMPH7A6 MT DTT DMPH7A6 MA Inhibitor DMPH7A6 RN Lipid-lowering (hetero)aromatic tetrahydro-1,4-oxazine derivatives with antioxidant and squalene synthase inhibitory activity. J Med Chem. 2008 Sep 25;51(18):5861-5. DMPH7A6 RU https://pubmed.ncbi.nlm.nih.gov/18754614 DM613NQ DI DM613NQ DM613NQ DN PMID18790648C10 DM613NQ MI TTZW4MV DM613NQ MN Matrix metalloproteinase-11 (MMP-11) DM613NQ MT DTT DM613NQ MA Inhibitor DM613NQ RN Specific targeting of metzincin family members with small-molecule inhibitors: progress toward a multifarious challenge. Bioorg Med Chem. 2008 Oct 1;16(19):8781-94. DM613NQ RU https://pubmed.ncbi.nlm.nih.gov/18790648 DM4UWKR DI DM4UWKR DM4UWKR DN PMID18800762C11 DM4UWKR MI TTIKWV4 DM4UWKR MN Geranyltranstransferase (FDPS) DM4UWKR MT DTT DM4UWKR MA Inhibitor DM4UWKR RN Inhibition of geranylgeranyl diphosphate synthase by bisphosphonates: a crystallographic and computational investigation. J Med Chem. 2008 Sep 25;51(18):5594-607. DM4UWKR RU https://pubmed.ncbi.nlm.nih.gov/18800762 DM5T2FR DI DM5T2FR DM5T2FR DN PMID18800762C14 DM5T2FR MI TTIKWV4 DM5T2FR MN Geranyltranstransferase (FDPS) DM5T2FR MT DTT DM5T2FR MA Inhibitor DM5T2FR RN Inhibition of geranylgeranyl diphosphate synthase by bisphosphonates: a crystallographic and computational investigation. J Med Chem. 2008 Sep 25;51(18):5594-607. DM5T2FR RU https://pubmed.ncbi.nlm.nih.gov/18800762 DM70SEQ DI DM70SEQ DM70SEQ DN PMID18800762C16 DM70SEQ MI TTIKWV4 DM70SEQ MN Geranyltranstransferase (FDPS) DM70SEQ MT DTT DM70SEQ MA Inhibitor DM70SEQ RN Inhibition of geranylgeranyl diphosphate synthase by bisphosphonates: a crystallographic and computational investigation. J Med Chem. 2008 Sep 25;51(18):5594-607. DM70SEQ RU https://pubmed.ncbi.nlm.nih.gov/18800762 DM1QXFI DI DM1QXFI DM1QXFI DN PMID18800762C19 DM1QXFI MI TTIKWV4 DM1QXFI MN Geranyltranstransferase (FDPS) DM1QXFI MT DTT DM1QXFI MA Inhibitor DM1QXFI RN Inhibition of geranylgeranyl diphosphate synthase by bisphosphonates: a crystallographic and computational investigation. J Med Chem. 2008 Sep 25;51(18):5594-607. DM1QXFI RU https://pubmed.ncbi.nlm.nih.gov/18800762 DMZDC14 DI DMZDC14 DMZDC14 DN PMID18800762C47 DMZDC14 MI TTIKWV4 DMZDC14 MN Geranyltranstransferase (FDPS) DMZDC14 MT DTT DMZDC14 MA Inhibitor DMZDC14 RN Inhibition of geranylgeranyl diphosphate synthase by bisphosphonates: a crystallographic and computational investigation. J Med Chem. 2008 Sep 25;51(18):5594-607. DMZDC14 RU https://pubmed.ncbi.nlm.nih.gov/18800762 DMWFGY4 DI DMWFGY4 DMWFGY4 DN PMID18800762C51 DMWFGY4 MI TTIKWV4 DMWFGY4 MN Geranyltranstransferase (FDPS) DMWFGY4 MT DTT DMWFGY4 MA Inhibitor DMWFGY4 RN Inhibition of geranylgeranyl diphosphate synthase by bisphosphonates: a crystallographic and computational investigation. J Med Chem. 2008 Sep 25;51(18):5594-607. DMWFGY4 RU https://pubmed.ncbi.nlm.nih.gov/18800762 DMA5P9Q DI DMA5P9Q DMA5P9Q DN PMID1895299C1 DMA5P9Q MI TTPADOQ DMA5P9Q MN HMG-CoA reductase (HMGCR) DMA5P9Q MT DTT DMA5P9Q MA Inhibitor DMA5P9Q RN Phosphorus-containing inhibitors of HMG-CoA reductase. 2. Synthesis and biological activities of a series of substituted pyridines containing a hydroxyphosphinyl moiety. J Med Chem. 1991 Sep;34(9):2804-15. DMA5P9Q RU https://pubmed.ncbi.nlm.nih.gov/1895299 DMAZWHB DI DMAZWHB DMAZWHB DN PMID1895299C4p DMAZWHB MI TTPADOQ DMAZWHB MN HMG-CoA reductase (HMGCR) DMAZWHB MT DTT DMAZWHB MA Inhibitor DMAZWHB RN Phosphorus-containing inhibitors of HMG-CoA reductase. 2. Synthesis and biological activities of a series of substituted pyridines containing a hydroxyphosphinyl moiety. J Med Chem. 1991 Sep;34(9):2804-15. DMAZWHB RU https://pubmed.ncbi.nlm.nih.gov/1895299 DM384PH DI DM384PH DM384PH DN PMID1895299C6v DM384PH MI TTPADOQ DM384PH MN HMG-CoA reductase (HMGCR) DM384PH MT DTT DM384PH MA Inhibitor DM384PH RN Phosphorus-containing inhibitors of HMG-CoA reductase. 2. Synthesis and biological activities of a series of substituted pyridines containing a hydroxyphosphinyl moiety. J Med Chem. 1991 Sep;34(9):2804-15. DM384PH RU https://pubmed.ncbi.nlm.nih.gov/1895299 DMFU6AI DI DMFU6AI DMFU6AI DN PMID18986805C9b DMFU6AI MI TTH6V3D DMFU6AI MN Cyclin-dependent kinase 1 (CDK1) DMFU6AI MT DTT DMFU6AI MA Inhibitor DMFU6AI RN Imidazole pyrimidine amides as potent, orally bioavailable cyclin-dependent kinase inhibitors. Bioorg Med Chem Lett. 2008 Dec 15;18(24):6486-9. DMFU6AI RU https://pubmed.ncbi.nlm.nih.gov/18986805 DMFU6AI DI DMFU6AI DMFU6AI DN PMID18986805C9b DMFU6AI MI TT7HF4W DMFU6AI MN Cyclin-dependent kinase 2 (CDK2) DMFU6AI MT DTT DMFU6AI MA Inhibitor DMFU6AI RN Imidazole pyrimidine amides as potent, orally bioavailable cyclin-dependent kinase inhibitors. Bioorg Med Chem Lett. 2008 Dec 15;18(24):6486-9. DMFU6AI RU https://pubmed.ncbi.nlm.nih.gov/18986805 DMFU6AI DI DMFU6AI DMFU6AI DN PMID18986805C9b DMFU6AI MI TT0PG8F DMFU6AI MN Cyclin-dependent kinase 4 (CDK4) DMFU6AI MT DTT DMFU6AI MA Inhibitor DMFU6AI RN Imidazole pyrimidine amides as potent, orally bioavailable cyclin-dependent kinase inhibitors. Bioorg Med Chem Lett. 2008 Dec 15;18(24):6486-9. DMFU6AI RU https://pubmed.ncbi.nlm.nih.gov/18986805 DMFU6AI DI DMFU6AI DMFU6AI DN PMID18986805C9b DMFU6AI MI TTBTI6P DMFU6AI MN Cyclin-dependent kinase-like 1 (CDKL1) DMFU6AI MT DTT DMFU6AI MA Inhibitor DMFU6AI RN Imidazole pyrimidine amides as potent, orally bioavailable cyclin-dependent kinase inhibitors. Bioorg Med Chem Lett. 2008 Dec 15;18(24):6486-9. DMFU6AI RU https://pubmed.ncbi.nlm.nih.gov/18986805 DMH70UC DI DMH70UC DMH70UC DN PMID19097784C2 DMH70UC MI TTIYVQP DMH70UC MN Polo-like kinase 1 (PLK1) DMH70UC MT DTT DMH70UC MA Inhibitor DMH70UC RN Discovery of thiophene inhibitors of polo-like kinase. Bioorg Med Chem Lett. 2009 Feb 1;19(3):1018-21. DMH70UC RU https://pubmed.ncbi.nlm.nih.gov/19097784 DMVTXKI DI DMVTXKI DMVTXKI DN PMID19111466C7d DMVTXKI MI TT5ZKDI DMVTXKI MN Histone deacetylase 6 (HDAC6) DMVTXKI MT DTT DMVTXKI MA Inhibitor DMVTXKI RN Novel HDAC6 isoform selective chiral small molecule histone deacetylase inhibitors. Bioorg Med Chem Lett. 2009 Feb 1;19(3):688-92. DMVTXKI RU https://pubmed.ncbi.nlm.nih.gov/19111466 DMB9F2L DI DMB9F2L DMB9F2L DN PMID19115845C89S DMB9F2L MI TTSMTDI DMB9F2L MN CDC7-related kinase (CDC7) DMB9F2L MT DTT DMB9F2L MA Inhibitor DMB9F2L RN First Cdc7 kinase inhibitors: pyrrolopyridinones as potent and orally active antitumor agents. 2. Lead discovery. J Med Chem. 2009 Jan 22;52(2):293-307. DMB9F2L RU https://pubmed.ncbi.nlm.nih.gov/19115845 DMB9F2L DI DMB9F2L DMB9F2L DN PMID19115845C89S DMB9F2L MI TTH6V3D DMB9F2L MN Cyclin-dependent kinase 1 (CDK1) DMB9F2L MT DTT DMB9F2L MA Inhibitor DMB9F2L RN First Cdc7 kinase inhibitors: pyrrolopyridinones as potent and orally active antitumor agents. 2. Lead discovery. J Med Chem. 2009 Jan 22;52(2):293-307. DMB9F2L RU https://pubmed.ncbi.nlm.nih.gov/19115845 DMB9F2L DI DMB9F2L DMB9F2L DN PMID19115845C89S DMB9F2L MI TT7HF4W DMB9F2L MN Cyclin-dependent kinase 2 (CDK2) DMB9F2L MT DTT DMB9F2L MA Inhibitor DMB9F2L RN First Cdc7 kinase inhibitors: pyrrolopyridinones as potent and orally active antitumor agents. 2. Lead discovery. J Med Chem. 2009 Jan 22;52(2):293-307. DMB9F2L RU https://pubmed.ncbi.nlm.nih.gov/19115845 DMB9F2L DI DMB9F2L DMB9F2L DN PMID19115845C89S DMB9F2L MI TT1LVF2 DMB9F2L MN Cyclin-dependent kinase 9 (CDK9) DMB9F2L MT DTT DMB9F2L MA Inhibitor DMB9F2L RN First Cdc7 kinase inhibitors: pyrrolopyridinones as potent and orally active antitumor agents. 2. Lead discovery. J Med Chem. 2009 Jan 22;52(2):293-307. DMB9F2L RU https://pubmed.ncbi.nlm.nih.gov/19115845 DMB9F2L DI DMB9F2L DMB9F2L DN PMID19115845C89S DMB9F2L MI TTRSMW9 DMB9F2L MN Glycogen synthase kinase-3 beta (GSK-3B) DMB9F2L MT DTT DMB9F2L MA Inhibitor DMB9F2L RN First Cdc7 kinase inhibitors: pyrrolopyridinones as potent and orally active antitumor agents. 2. Lead discovery. J Med Chem. 2009 Jan 22;52(2):293-307. DMB9F2L RU https://pubmed.ncbi.nlm.nih.gov/19115845 DMB9F2L DI DMB9F2L DMB9F2L DN PMID19115845C89S DMB9F2L MI TTO7L0V DMB9F2L MN TAO kinase 3 (TAOK3) DMB9F2L MT DTT DMB9F2L MA Inhibitor DMB9F2L RN First Cdc7 kinase inhibitors: pyrrolopyridinones as potent and orally active antitumor agents. 2. Lead discovery. J Med Chem. 2009 Jan 22;52(2):293-307. DMB9F2L RU https://pubmed.ncbi.nlm.nih.gov/19115845 DMG7D3I DI DMG7D3I DMG7D3I DN PMID19191557C14 DMG7D3I MI TTFQEO5 DMG7D3I MN Squalene synthetase (FDFT1) DMG7D3I MT DTT DMG7D3I MA Inhibitor DMG7D3I RN Phosphonosulfonates are potent, selective inhibitors of dehydrosqualene synthase and staphyloxanthin biosynthesis in Staphylococcus aureus. J Med Chem. 2009 Feb 26;52(4):976-88. DMG7D3I RU https://pubmed.ncbi.nlm.nih.gov/19191557 DMXLVEC DI DMXLVEC DMXLVEC DN PMID19191557C19 DMXLVEC MI TTFQEO5 DMXLVEC MN Squalene synthetase (FDFT1) DMXLVEC MT DTT DMXLVEC MA Inhibitor DMXLVEC RN Phosphonosulfonates are potent, selective inhibitors of dehydrosqualene synthase and staphyloxanthin biosynthesis in Staphylococcus aureus. J Med Chem. 2009 Feb 26;52(4):976-88. DMXLVEC RU https://pubmed.ncbi.nlm.nih.gov/19191557 DM5RIB0 DI DM5RIB0 DM5RIB0 DN PMID19191557C21 DM5RIB0 MI TTFQEO5 DM5RIB0 MN Squalene synthetase (FDFT1) DM5RIB0 MT DTT DM5RIB0 MA Inhibitor DM5RIB0 RN Phosphonosulfonates are potent, selective inhibitors of dehydrosqualene synthase and staphyloxanthin biosynthesis in Staphylococcus aureus. J Med Chem. 2009 Feb 26;52(4):976-88. DM5RIB0 RU https://pubmed.ncbi.nlm.nih.gov/19191557 DM1MEY3 DI DM1MEY3 DM1MEY3 DN PMID19191557C3 DM1MEY3 MI TTFQEO5 DM1MEY3 MN Squalene synthetase (FDFT1) DM1MEY3 MT DTT DM1MEY3 MA Inhibitor DM1MEY3 RN Phosphonosulfonates are potent, selective inhibitors of dehydrosqualene synthase and staphyloxanthin biosynthesis in Staphylococcus aureus. J Med Chem. 2009 Feb 26;52(4):976-88. DM1MEY3 RU https://pubmed.ncbi.nlm.nih.gov/19191557 DMH8QRI DI DMH8QRI DMH8QRI DN PMID19191557C32 DMH8QRI MI TTFQEO5 DMH8QRI MN Squalene synthetase (FDFT1) DMH8QRI MT DTT DMH8QRI MA Inhibitor DMH8QRI RN Phosphonosulfonates are potent, selective inhibitors of dehydrosqualene synthase and staphyloxanthin biosynthesis in Staphylococcus aureus. J Med Chem. 2009 Feb 26;52(4):976-88. DMH8QRI RU https://pubmed.ncbi.nlm.nih.gov/19191557 DM09IEK DI DM09IEK DM09IEK DN PMID19191557C35 DM09IEK MI TTFQEO5 DM09IEK MN Squalene synthetase (FDFT1) DM09IEK MT DTT DM09IEK MA Inhibitor DM09IEK RN Phosphonosulfonates are potent, selective inhibitors of dehydrosqualene synthase and staphyloxanthin biosynthesis in Staphylococcus aureus. J Med Chem. 2009 Feb 26;52(4):976-88. DM09IEK RU https://pubmed.ncbi.nlm.nih.gov/19191557 DMUWYA2 DI DMUWYA2 DMUWYA2 DN PMID19191557C8 DMUWYA2 MI TTFQEO5 DMUWYA2 MN Squalene synthetase (FDFT1) DMUWYA2 MT DTT DMUWYA2 MA Inhibitor DMUWYA2 RN Phosphonosulfonates are potent, selective inhibitors of dehydrosqualene synthase and staphyloxanthin biosynthesis in Staphylococcus aureus. J Med Chem. 2009 Feb 26;52(4):976-88. DMUWYA2 RU https://pubmed.ncbi.nlm.nih.gov/19191557 DMJRLB5 DI DMJRLB5 DMJRLB5 DN PMID19289283C22 DMJRLB5 MI TTVBPDM DMJRLB5 MN Metabotropic glutamate receptor 1 (mGluR1) DMJRLB5 MT DTT DMJRLB5 MA Modulator (allosteric modulator) DMJRLB5 RN In vitro and in vivo SAR of pyrido[3,4-d]pyramid-4-ylamine based mGluR1 antagonists. Bioorg Med Chem Lett. 2009 Apr 15;19(8):2190-4. DMJRLB5 RU https://pubmed.ncbi.nlm.nih.gov/19289283 DMSKGEJ DI DMSKGEJ DMSKGEJ DN PMID19289283C32 DMSKGEJ MI TTVBPDM DMSKGEJ MN Metabotropic glutamate receptor 1 (mGluR1) DMSKGEJ MT DTT DMSKGEJ MA Modulator (allosteric modulator) DMSKGEJ RN In vitro and in vivo SAR of pyrido[3,4-d]pyramid-4-ylamine based mGluR1 antagonists. Bioorg Med Chem Lett. 2009 Apr 15;19(8):2190-4. DMSKGEJ RU https://pubmed.ncbi.nlm.nih.gov/19289283 DMTASYN DI DMTASYN DMTASYN DN PMID19309152C2g DMTASYN MI TTWNV8U DMTASYN MN Nicotinic acid receptor (HCAR2) DMTASYN MT DTT DMTASYN MA Agonist DMTASYN RN Discovery of novel tricyclic full agonists for the G-protein-coupled niacin receptor 109A with minimized flushing in rats. J Med Chem. 2009 Apr 23;52(8):2587-602. DMTASYN RU https://pubmed.ncbi.nlm.nih.gov/19309152 DMSE1C3 DI DMSE1C3 DMSE1C3 DN PMID19364658C33 DMSE1C3 MI TTQR5YD DMSE1C3 MN Casein kinase I gamma-1 (CSNK1G1) DMSE1C3 MT DTT DMSE1C3 MA Inhibitor DMSE1C3 RN Identification and SAR of squarate inhibitors of mitogen activated protein kinase-activated protein kinase 2 (MK-2). Bioorg Med Chem. 2009 May 1;17(9):3342-51. DMSE1C3 RU https://pubmed.ncbi.nlm.nih.gov/19364658 DMSE1C3 DI DMSE1C3 DMSE1C3 DN PMID19364658C33 DMSE1C3 MI TTTU902 DMSE1C3 MN Checkpoint kinase-1 (CHK1) DMSE1C3 MT DTT DMSE1C3 MA Inhibitor DMSE1C3 RN Identification and SAR of squarate inhibitors of mitogen activated protein kinase-activated protein kinase 2 (MK-2). Bioorg Med Chem. 2009 May 1;17(9):3342-51. DMSE1C3 RU https://pubmed.ncbi.nlm.nih.gov/19364658 DMSE1C3 DI DMSE1C3 DMSE1C3 DN PMID19364658C33 DMSE1C3 MI TTYVI76 DMSE1C3 MN Fungal Protein kinase A (Fung ypkA) DMSE1C3 MT DTT DMSE1C3 MA Inhibitor DMSE1C3 RN Identification and SAR of squarate inhibitors of mitogen activated protein kinase-activated protein kinase 2 (MK-2). Bioorg Med Chem. 2009 May 1;17(9):3342-51. DMSE1C3 RU https://pubmed.ncbi.nlm.nih.gov/19364658 DMSE1C3 DI DMSE1C3 DMSE1C3 DN PMID19364658C33 DMSE1C3 MI TTMUG9D DMSE1C3 MN MAPK-activated protein kinase 2 (MAPKAPK2) DMSE1C3 MT DTT DMSE1C3 MA Inhibitor DMSE1C3 RN Identification and SAR of squarate inhibitors of mitogen activated protein kinase-activated protein kinase 2 (MK-2). Bioorg Med Chem. 2009 May 1;17(9):3342-51. DMSE1C3 RU https://pubmed.ncbi.nlm.nih.gov/19364658 DMSE1C3 DI DMSE1C3 DMSE1C3 DN PMID19364658C33 DMSE1C3 MI TTZN7RP DMSE1C3 MN Rho-associated protein kinase 1 (ROCK1) DMSE1C3 MT DTT DMSE1C3 MA Inhibitor DMSE1C3 RN Identification and SAR of squarate inhibitors of mitogen activated protein kinase-activated protein kinase 2 (MK-2). Bioorg Med Chem. 2009 May 1;17(9):3342-51. DMSE1C3 RU https://pubmed.ncbi.nlm.nih.gov/19364658 DMSE1C3 DI DMSE1C3 DMSE1C3 DN PMID19364658C33 DMSE1C3 MI TTIXKA4 DMSE1C3 MN Ribosomal protein S6 kinase alpha-1 (RSK1) DMSE1C3 MT DTT DMSE1C3 MA Inhibitor DMSE1C3 RN Identification and SAR of squarate inhibitors of mitogen activated protein kinase-activated protein kinase 2 (MK-2). Bioorg Med Chem. 2009 May 1;17(9):3342-51. DMSE1C3 RU https://pubmed.ncbi.nlm.nih.gov/19364658 DMPXEIQ DI DMPXEIQ DMPXEIQ DN PMID19433355C11q DMPXEIQ MI TTVBPDM DMPXEIQ MN Metabotropic glutamate receptor 1 (mGluR1) DMPXEIQ MT DTT DMPXEIQ MA Modulator (allosteric modulator) DMPXEIQ RN Tricyclic thienopyridine-pyrimidones/thienopyrimidine-pyrimidones as orally efficacious mGluR1 antagonists for neuropathic pain. Bioorg Med Chem Lett. 2009 Jun 15;19(12):3199-203. DMPXEIQ RU https://pubmed.ncbi.nlm.nih.gov/19433355 DMBU0XJ DI DMBU0XJ DMBU0XJ DN PMID19433355C11s DMBU0XJ MI TTVBPDM DMBU0XJ MN Metabotropic glutamate receptor 1 (mGluR1) DMBU0XJ MT DTT DMBU0XJ MA Modulator (allosteric modulator) DMBU0XJ RN Tricyclic thienopyridine-pyrimidones/thienopyrimidine-pyrimidones as orally efficacious mGluR1 antagonists for neuropathic pain. Bioorg Med Chem Lett. 2009 Jun 15;19(12):3199-203. DMBU0XJ RU https://pubmed.ncbi.nlm.nih.gov/19433355 DMBU9E4 DI DMBU9E4 DMBU9E4 DN PMID19456099C13 DMBU9E4 MI TTFQEO5 DMBU9E4 MN Squalene synthetase (FDFT1) DMBU9E4 MT DTT DMBU9E4 MA Inhibitor DMBU9E4 RN Inhibition of staphyloxanthin virulence factor biosynthesis in Staphylococcus aureus: in vitro, in vivo, and crystallographic results. J Med Chem. 2009 Jul 9;52(13):3869-80. DMBU9E4 RU https://pubmed.ncbi.nlm.nih.gov/19456099 DMPZMS0 DI DMPZMS0 DMPZMS0 DN PMID19456099C15 DMPZMS0 MI TTFQEO5 DMPZMS0 MN Squalene synthetase (FDFT1) DMPZMS0 MT DTT DMPZMS0 MA Inhibitor DMPZMS0 RN Inhibition of staphyloxanthin virulence factor biosynthesis in Staphylococcus aureus: in vitro, in vivo, and crystallographic results. J Med Chem. 2009 Jul 9;52(13):3869-80. DMPZMS0 RU https://pubmed.ncbi.nlm.nih.gov/19456099 DMTRL0X DI DMTRL0X DMTRL0X DN PMID19502059C25d DMTRL0X MI TTPADOQ DMTRL0X MN HMG-CoA reductase (HMGCR) DMTRL0X MT DTT DMTRL0X MA Inhibitor DMTRL0X RN Application of a 3,3-diphenylpentane skeleton as a multi-template for creation of HMG-CoA reductase inhibitors. Bioorg Med Chem Lett. 2009 Aug 1;19(15):4228-31. DMTRL0X RU https://pubmed.ncbi.nlm.nih.gov/19502059 DMK5JB8 DI DMK5JB8 DMK5JB8 DN PMID19524438C6o DMK5JB8 MI TT8WFXV DMK5JB8 MN Hydroxycarboxylic acid receptor 3 (HCAR3) DMK5JB8 MT DTT DMK5JB8 MA Agonist DMK5JB8 RN 5-N,N-Disubstituted 5-aminopyrazole-3-carboxylic acids are highly potent agonists of GPR109b. Bioorg Med Chem Lett. 2009 Aug 1;19(15):4207-9. DMK5JB8 RU https://pubmed.ncbi.nlm.nih.gov/19524438 DMRWM24 DI DMRWM24 DMRWM24 DN PMID19632837C17f DMRWM24 MI TTIZQFJ DMRWM24 MN Histone-arginine methyltransferase CARM1 (CARM1) DMRWM24 MT DTT DMRWM24 MA Inhibitor DMRWM24 RN Benzo[d]imidazole inhibitors of Coactivator Associated Arginine Methyltransferase 1 (CARM1)--Hit to Lead studies. Bioorg Med Chem Lett. 2009 Sep 1;19(17):5063-6. DMRWM24 RU https://pubmed.ncbi.nlm.nih.gov/19632837 DMTX0ZJ DI DMTX0ZJ DMTX0ZJ DN PMID19743866C51 DMTX0ZJ MI TTA0P7K DMTX0ZJ MN Complement factor B (CFB) DMTX0ZJ MT DTT DMTX0ZJ MA Inhibitor DMTX0ZJ RN Structure-activity relationships for substrate-based inhibitors of human complement factor B. J Med Chem. 2009 Oct 8;52(19):6042-52. DMTX0ZJ RU https://pubmed.ncbi.nlm.nih.gov/19743866 DMCVJK9 DI DMCVJK9 DMCVJK9 DN PMID19788238C66 DMCVJK9 MI TTLFZVU DMCVJK9 MN Ephrin type-A receptor 1 (EPHA1) DMCVJK9 MT DTT DMCVJK9 MA Inhibitor DMCVJK9 RN Structure-based optimization of potent and selective inhibitors of the tyrosine kinase erythropoietin producing human hepatocellular carcinoma receptor B4 (EphB4). J Med Chem. 2009 Oct 22;52(20):6433-46. DMCVJK9 RU https://pubmed.ncbi.nlm.nih.gov/19788238 DMCVJK9 DI DMCVJK9 DMCVJK9 DN PMID19788238C66 DMCVJK9 MI TTRJB2G DMCVJK9 MN Ephrin type-A receptor 2 (EPHA2) DMCVJK9 MT DTT DMCVJK9 MA Inhibitor DMCVJK9 RN Structure-based optimization of potent and selective inhibitors of the tyrosine kinase erythropoietin producing human hepatocellular carcinoma receptor B4 (EphB4). J Med Chem. 2009 Oct 22;52(20):6433-46. DMCVJK9 RU https://pubmed.ncbi.nlm.nih.gov/19788238 DMCVJK9 DI DMCVJK9 DMCVJK9 DN PMID19788238C66 DMCVJK9 MI TTHS2LR DMCVJK9 MN Ephrin type-A receptor 3 (EPHA3) DMCVJK9 MT DTT DMCVJK9 MA Inhibitor DMCVJK9 RN Structure-based optimization of potent and selective inhibitors of the tyrosine kinase erythropoietin producing human hepatocellular carcinoma receptor B4 (EphB4). J Med Chem. 2009 Oct 22;52(20):6433-46. DMCVJK9 RU https://pubmed.ncbi.nlm.nih.gov/19788238 DMCVJK9 DI DMCVJK9 DMCVJK9 DN PMID19788238C66 DMCVJK9 MI TTG84D3 DMCVJK9 MN Ephrin type-A receptor 4 (EPHA4) DMCVJK9 MT DTT DMCVJK9 MA Inhibitor DMCVJK9 RN Structure-based optimization of potent and selective inhibitors of the tyrosine kinase erythropoietin producing human hepatocellular carcinoma receptor B4 (EphB4). J Med Chem. 2009 Oct 22;52(20):6433-46. DMCVJK9 RU https://pubmed.ncbi.nlm.nih.gov/19788238 DMCVJK9 DI DMCVJK9 DMCVJK9 DN PMID19788238C66 DMCVJK9 MI TTV9KOD DMCVJK9 MN Ephrin type-A receptor 5 (EPHA5) DMCVJK9 MT DTT DMCVJK9 MA Inhibitor DMCVJK9 RN Structure-based optimization of potent and selective inhibitors of the tyrosine kinase erythropoietin producing human hepatocellular carcinoma receptor B4 (EphB4). J Med Chem. 2009 Oct 22;52(20):6433-46. DMCVJK9 RU https://pubmed.ncbi.nlm.nih.gov/19788238 DMCVJK9 DI DMCVJK9 DMCVJK9 DN PMID19788238C66 DMCVJK9 MI TTAHTVG DMCVJK9 MN Ephrin type-A receptor 7 (EPHA7) DMCVJK9 MT DTT DMCVJK9 MA Inhibitor DMCVJK9 RN Structure-based optimization of potent and selective inhibitors of the tyrosine kinase erythropoietin producing human hepatocellular carcinoma receptor B4 (EphB4). J Med Chem. 2009 Oct 22;52(20):6433-46. DMCVJK9 RU https://pubmed.ncbi.nlm.nih.gov/19788238 DMCVJK9 DI DMCVJK9 DMCVJK9 DN PMID19788238C66 DMCVJK9 MI TTHZ2LW DMCVJK9 MN Ephrin type-A receptor 8 (EPHA8) DMCVJK9 MT DTT DMCVJK9 MA Inhibitor DMCVJK9 RN Structure-based optimization of potent and selective inhibitors of the tyrosine kinase erythropoietin producing human hepatocellular carcinoma receptor B4 (EphB4). J Med Chem. 2009 Oct 22;52(20):6433-46. DMCVJK9 RU https://pubmed.ncbi.nlm.nih.gov/19788238 DMCVJK9 DI DMCVJK9 DMCVJK9 DN PMID19788238C66 DMCVJK9 MI TT8MDAC DMCVJK9 MN Ephrin type-B receptor 1 (EPHB1) DMCVJK9 MT DTT DMCVJK9 MA Inhibitor DMCVJK9 RN Structure-based optimization of potent and selective inhibitors of the tyrosine kinase erythropoietin producing human hepatocellular carcinoma receptor B4 (EphB4). J Med Chem. 2009 Oct 22;52(20):6433-46. DMCVJK9 RU https://pubmed.ncbi.nlm.nih.gov/19788238 DMCVJK9 DI DMCVJK9 DMCVJK9 DN PMID19788238C66 DMCVJK9 MI TTKPV6O DMCVJK9 MN Ephrin type-B receptor 2 (EPHB2) DMCVJK9 MT DTT DMCVJK9 MA Inhibitor DMCVJK9 RN Structure-based optimization of potent and selective inhibitors of the tyrosine kinase erythropoietin producing human hepatocellular carcinoma receptor B4 (EphB4). J Med Chem. 2009 Oct 22;52(20):6433-46. DMCVJK9 RU https://pubmed.ncbi.nlm.nih.gov/19788238 DMCVJK9 DI DMCVJK9 DMCVJK9 DN PMID19788238C66 DMCVJK9 MI TT5LM7U DMCVJK9 MN Ephrin type-B receptor 3 (EPHB3) DMCVJK9 MT DTT DMCVJK9 MA Inhibitor DMCVJK9 RN Structure-based optimization of potent and selective inhibitors of the tyrosine kinase erythropoietin producing human hepatocellular carcinoma receptor B4 (EphB4). J Med Chem. 2009 Oct 22;52(20):6433-46. DMCVJK9 RU https://pubmed.ncbi.nlm.nih.gov/19788238 DMCVJK9 DI DMCVJK9 DMCVJK9 DN PMID19788238C66 DMCVJK9 MI TTI4ZX2 DMCVJK9 MN Ephrin type-B receptor 4 (EPHB4) DMCVJK9 MT DTT DMCVJK9 MA Inhibitor DMCVJK9 RN Structure-based optimization of potent and selective inhibitors of the tyrosine kinase erythropoietin producing human hepatocellular carcinoma receptor B4 (EphB4). J Med Chem. 2009 Oct 22;52(20):6433-46. DMCVJK9 RU https://pubmed.ncbi.nlm.nih.gov/19788238 DMQXK4B DI DMQXK4B DMQXK4B DN PMID19800804C12 DMQXK4B MI TTE2YJR DMQXK4B MN Lysophosphatidate-3 receptor (LPAR3) DMQXK4B MT DTT DMQXK4B MA Antagonist DMQXK4B RN Structure-based drug design identifies novel LPA3 antagonists. Bioorg Med Chem. 2009 Nov 1;17(21):7457-64. DMQXK4B RU https://pubmed.ncbi.nlm.nih.gov/19800804 DMIECOF DI DMIECOF DMIECOF DN PMID19831390C14 DMIECOF MI TTWL9TY DMIECOF MN LIM domain kinase-1 (LIMK-1) DMIECOF MT DTT DMIECOF MA Inhibitor DMIECOF RN Novel class of LIM-kinase 2 inhibitors for the treatment of ocular hypertension and associated glaucoma. J Med Chem. 2009 Nov 12;52(21):6515-8. DMIECOF RU https://pubmed.ncbi.nlm.nih.gov/19831390 DMIECOF DI DMIECOF DMIECOF DN PMID19831390C14 DMIECOF MI TTASMD8 DMIECOF MN LIM domain kinase-2 (LIMK-2) DMIECOF MT DTT DMIECOF MA Inhibitor DMIECOF RN Novel class of LIM-kinase 2 inhibitors for the treatment of ocular hypertension and associated glaucoma. J Med Chem. 2009 Nov 12;52(21):6515-8. DMIECOF RU https://pubmed.ncbi.nlm.nih.gov/19831390 DM8T6VG DI DM8T6VG DM8T6VG DN PMID19831390C22m DM8T6VG MI TTASMD8 DM8T6VG MN LIM domain kinase-2 (LIMK-2) DM8T6VG MT DTT DM8T6VG MA Inhibitor DM8T6VG RN Novel class of LIM-kinase 2 inhibitors for the treatment of ocular hypertension and associated glaucoma. J Med Chem. 2009 Nov 12;52(21):6515-8. DM8T6VG RU https://pubmed.ncbi.nlm.nih.gov/19831390 DMEGPBS DI DMEGPBS DMEGPBS DN PMID19854648C27 DMEGPBS MI TTRUJBV DMEGPBS MN Eukaryotic translation initiation factor 2-alpha kinase 1 (EIF2AK1) DMEGPBS MT DTT DMEGPBS MA Inhibitor DMEGPBS RN Discovery of the first known small-molecule inhibitors of heme-regulated eukaryotic initiation factor 2alpha (HRI) kinase. Bioorg Med Chem Lett. 2009 Dec 1;19(23):6548-51. DMEGPBS RU https://pubmed.ncbi.nlm.nih.gov/19854648 DMBTV20 DI DMBTV20 DMBTV20 DN PMID19899765C22 DMBTV20 MI TTQ9RYT DMBTV20 MN Endothelin-converting enzyme 1 (ECE1) DMBTV20 MT DTT DMBTV20 MA Inhibitor DMBTV20 RN Phosphinic tripeptides as dual angiotensin-converting enzyme C-domain and endothelin-converting enzyme-1 inhibitors. J Med Chem. 2010 Jan 14;53(1):208-20. DMBTV20 RU https://pubmed.ncbi.nlm.nih.gov/19899765 DMI3PCZ DI DMI3PCZ DMI3PCZ DN PMID1992138C8b DMI3PCZ MI TTPADOQ DMI3PCZ MN HMG-CoA reductase (HMGCR) DMI3PCZ MT DTT DMI3PCZ MA Inhibitor DMI3PCZ RN Inhibitors of cholesterol biosynthesis. 4. trans-6-[2-(substituted-quinolinyl)ethenyl/ethyl]tetrahydro-4-hydroxy-2 H-pyran-2-ones, a novel series of HMG-CoA reductase inhibitors. J Med Chem. 1991 Jan;34(1):367-73. DMI3PCZ RU https://pubmed.ncbi.nlm.nih.gov/1992138 DM2X1NY DI DM2X1NY DM2X1NY DN PMID1992149C13 DM2X1NY MI TTPADOQ DM2X1NY MN HMG-CoA reductase (HMGCR) DM2X1NY MT DTT DM2X1NY MA Inhibitor DM2X1NY RN Relationship between tissue selectivity and lipophilicity for inhibitors of HMG-CoA reductase. J Med Chem. 1991 Jan;34(1):463-6. DM2X1NY RU https://pubmed.ncbi.nlm.nih.gov/1992149 DM9RENG DI DM9RENG DM9RENG DN PMID1992149C9 DM9RENG MI TTPADOQ DM9RENG MN HMG-CoA reductase (HMGCR) DM9RENG MT DTT DM9RENG MA Inhibitor DM9RENG RN Inhibitors of cholesterol biosynthesis. 6. trans-6-[2-(2-N-heteroaryl-3,5-disubstituted- pyrazol-4-yl)ethyl/ethenyl]tetrahydro-4-hydroxy-2H-pyran-2-ones. J Med Chem. 1992 May 29;35(11):2095-103. DM9RENG RU https://pubmed.ncbi.nlm.nih.gov/1597859 DM3DCR9 DI DM3DCR9 DM3DCR9 DN PMID19931453C16m DM3DCR9 MI TTHS256 DM3DCR9 MN Metabotropic glutamate receptor 5 (mGluR5) DM3DCR9 MT DTT DM3DCR9 MA Modulator (allosteric modulator) DM3DCR9 RN Piperidyl amides as novel, potent and orally active mGlu5 receptor antagonists with anxiolytic-like activity. Bioorg Med Chem Lett. 2010 Jan 1;20(1):184-8. DM3DCR9 RU https://pubmed.ncbi.nlm.nih.gov/19931453 DMDYZE5 DI DMDYZE5 DMDYZE5 DN PMID19954973C4 DMDYZE5 MI TT4UJX5 DMDYZE5 MN Carboxypeptidase B1 (CPB1) DMDYZE5 MT DTT DMDYZE5 MA Inhibitor DMDYZE5 RN Oxygenated analogues of UK-396082 as inhibitors of activated thrombin activatable fibrinolysis inhibitor. Bioorg Med Chem Lett. 2010 Jan 1;20(1):92-6. DMDYZE5 RU https://pubmed.ncbi.nlm.nih.gov/19954973 DMDYZE5 DI DMDYZE5 DMDYZE5 DN PMID19954973C4 DMDYZE5 MI TTP18AY DMDYZE5 MN Carboxypeptidase B2 (CPB2) DMDYZE5 MT DTT DMDYZE5 MA Inhibitor DMDYZE5 RN Oxygenated analogues of UK-396082 as inhibitors of activated thrombin activatable fibrinolysis inhibitor. Bioorg Med Chem Lett. 2010 Jan 1;20(1):92-6. DMDYZE5 RU https://pubmed.ncbi.nlm.nih.gov/19954973 DMMESBW DI DMMESBW DMMESBW DN PMID20005102C1 DMMESBW MI TTYVI76 DMMESBW MN Fungal Protein kinase A (Fung ypkA) DMMESBW MT DTT DMMESBW MA Inhibitor DMMESBW RN 2,3,5-Trisubstituted pyridines as selective AKT inhibitors. Part II: Improved drug-like properties and kinase selectivity from azaindazoles. Bioorg Med Chem Lett. 2010 Jan 15;20(2):679-83. DMMESBW RU https://pubmed.ncbi.nlm.nih.gov/20005102 DMMESBW DI DMMESBW DMMESBW DN PMID20005102C1 DMMESBW MI TTFN95D DMMESBW MN PAK-1 protein kinase (PAK1) DMMESBW MT DTT DMMESBW MA Inhibitor DMMESBW RN 2,3,5-Trisubstituted pyridines as selective AKT inhibitors. Part II: Improved drug-like properties and kinase selectivity from azaindazoles. Bioorg Med Chem Lett. 2010 Jan 15;20(2):679-83. DMMESBW RU https://pubmed.ncbi.nlm.nih.gov/20005102 DMMESBW DI DMMESBW DMMESBW DN PMID20005102C1 DMMESBW MI TT9QBI6 DMMESBW MN Phosphoinositide dependent protein kinase-1 (PDPK1) DMMESBW MT DTT DMMESBW MA Inhibitor DMMESBW RN 2,3,5-Trisubstituted pyridines as selective AKT inhibitors. Part II: Improved drug-like properties and kinase selectivity from azaindazoles. Bioorg Med Chem Lett. 2010 Jan 15;20(2):679-83. DMMESBW RU https://pubmed.ncbi.nlm.nih.gov/20005102 DMMESBW DI DMMESBW DMMESBW DN PMID20005102C1 DMMESBW MI TTWTSCV DMMESBW MN RAC-alpha serine/threonine-protein kinase (AKT1) DMMESBW MT DTT DMMESBW MA Inhibitor DMMESBW RN 2,3,5-Trisubstituted pyridines as selective AKT inhibitors. Part II: Improved drug-like properties and kinase selectivity from azaindazoles. Bioorg Med Chem Lett. 2010 Jan 15;20(2):679-83. DMMESBW RU https://pubmed.ncbi.nlm.nih.gov/20005102 DMMESBW DI DMMESBW DMMESBW DN PMID20005102C1 DMMESBW MI TTH24WI DMMESBW MN RAC-beta serine/threonine-protein kinase (AKT2) DMMESBW MT DTT DMMESBW MA Inhibitor DMMESBW RN 2,3,5-Trisubstituted pyridines as selective AKT inhibitors. Part II: Improved drug-like properties and kinase selectivity from azaindazoles. Bioorg Med Chem Lett. 2010 Jan 15;20(2):679-83. DMMESBW RU https://pubmed.ncbi.nlm.nih.gov/20005102 DMMESBW DI DMMESBW DMMESBW DN PMID20005102C1 DMMESBW MI TTAZ05C DMMESBW MN RAC-gamma serine/threonine-protein kinase (AKT3) DMMESBW MT DTT DMMESBW MA Inhibitor DMMESBW RN 2,3,5-Trisubstituted pyridines as selective AKT inhibitors. Part II: Improved drug-like properties and kinase selectivity from azaindazoles. Bioorg Med Chem Lett. 2010 Jan 15;20(2):679-83. DMMESBW RU https://pubmed.ncbi.nlm.nih.gov/20005102 DMMESBW DI DMMESBW DMMESBW DN PMID20005102C1 DMMESBW MI TTG0U4H DMMESBW MN Ribosomal protein S6 kinase beta-1 (S6K1) DMMESBW MT DTT DMMESBW MA Inhibitor DMMESBW RN 2,3,5-Trisubstituted pyridines as selective AKT inhibitors. Part II: Improved drug-like properties and kinase selectivity from azaindazoles. Bioorg Med Chem Lett. 2010 Jan 15;20(2):679-83. DMMESBW RU https://pubmed.ncbi.nlm.nih.gov/20005102 DMV8ZFA DI DMV8ZFA DMV8ZFA DN PMID20080612C1 DMV8ZFA MI TT1ZAVI DMV8ZFA MN Prostaglandin E2 receptor EP2 (PTGER2) DMV8ZFA MT DTT DMV8ZFA MA Modulator (allosteric modulator) DMV8ZFA RN Neuroprotection by selective allosteric potentiators of the EP2 prostaglandin receptor. Proc Natl Acad Sci U S A. 2010 Feb 2;107(5):2307-12. DMV8ZFA RU https://pubmed.ncbi.nlm.nih.gov/20080612 DMM49JO DI DMM49JO DMM49JO DN PMID20121197C57 DMM49JO MI TTFEZ5Q DMM49JO MN Coagulation factor IX (F9) DMM49JO MT DTT DMM49JO MA Inhibitor DMM49JO RN Structure based drug design: development of potent and selective factor IXa (FIXa) inhibitors. J Med Chem. 2010 Feb 25;53(4):1473-82. DMM49JO RU https://pubmed.ncbi.nlm.nih.gov/20121197 DM8NGEQ DI DM8NGEQ DM8NGEQ DN PMID20167483C22e DM8NGEQ MI TTHYDUM DM8NGEQ MN Bombesin receptor (BS) DM8NGEQ MT DTT DM8NGEQ MA Agonist DM8NGEQ RN Discovery of substituted biphenyl imidazoles as potent, bioavailable bombesin receptor subtype-3 agonists. Bioorg Med Chem Lett. 2010 Mar 15;20(6):1913-7. DM8NGEQ RU https://pubmed.ncbi.nlm.nih.gov/20167483 DMKAZ1O DI DMKAZ1O DMKAZ1O DN PMID20299227C12 DMKAZ1O MI TTFQEO5 DMKAZ1O MN Squalene synthetase (FDFT1) DMKAZ1O MT DTT DMKAZ1O MA Inhibitor DMKAZ1O RN Synthesis and preliminary pharmacological characterisation of a new class of nitrogen-containing bisphosphonates (N-BPs). Bioorg Med Chem. 2010 Apr 1;18(7):2428-38. DMKAZ1O RU https://pubmed.ncbi.nlm.nih.gov/20299227 DM9H6LZ DI DM9H6LZ DM9H6LZ DN PMID20299227C20 DM9H6LZ MI TTFQEO5 DM9H6LZ MN Squalene synthetase (FDFT1) DM9H6LZ MT DTT DM9H6LZ MA Inhibitor DM9H6LZ RN Synthesis and preliminary pharmacological characterisation of a new class of nitrogen-containing bisphosphonates (N-BPs). Bioorg Med Chem. 2010 Apr 1;18(7):2428-38. DM9H6LZ RU https://pubmed.ncbi.nlm.nih.gov/20299227 DMLKFTE DI DMLKFTE DMLKFTE DN PMID20346665C24 DMLKFTE MI TTVBPDM DMLKFTE MN Metabotropic glutamate receptor 1 (mGluR1) DMLKFTE MT DTT DMLKFTE MA Modulator (allosteric modulator) DMLKFTE RN A-ring modifications on the triazafluorenone core structure and their mGluR1 antagonist properties. Bioorg Med Chem Lett. 2010 Apr 15;20(8):2474-7. DMLKFTE RU https://pubmed.ncbi.nlm.nih.gov/20346665 DMDKW6G DI DMDKW6G DMDKW6G DN PMID20346665C27 DMDKW6G MI TTVBPDM DMDKW6G MN Metabotropic glutamate receptor 1 (mGluR1) DMDKW6G MT DTT DMDKW6G MA Modulator (allosteric modulator) DMDKW6G RN A-ring modifications on the triazafluorenone core structure and their mGluR1 antagonist properties. Bioorg Med Chem Lett. 2010 Apr 15;20(8):2474-7. DMDKW6G RU https://pubmed.ncbi.nlm.nih.gov/20346665 DMCAXNU DI DMCAXNU DMCAXNU DN PMID20363624C(+)17a DMCAXNU MI TTWNV8U DMCAXNU MN Nicotinic acid receptor (HCAR2) DMCAXNU MT DTT DMCAXNU MA Agonist DMCAXNU RN Potent tricyclic pyrazole tetrazole agonists of the nicotinic acid receptor (GPR109a). Bioorg Med Chem Lett. 2010 May 1;20(9):2797-800. DMCAXNU RU https://pubmed.ncbi.nlm.nih.gov/20363624 DMA2Y74 DI DMA2Y74 DMA2Y74 DN PMID20409708C34 DMA2Y74 MI TTXJ47W DMA2Y74 MN Metabotropic glutamate receptor 2 (mGluR2) DMA2Y74 MT DTT DMA2Y74 MA Modulator (allosteric modulator) DMA2Y74 RN 3-Aryl-5-phenoxymethyl-1,3-oxazolidin-2-ones as positive allosteric modulators of mGluR2 for the treatment of schizophrenia: Hit-to-lead efforts. Bioorg Med Chem Lett. 2010 May 15;20(10):3129-33. DMA2Y74 RU https://pubmed.ncbi.nlm.nih.gov/20409708 DMQFKBI DI DMQFKBI DMQFKBI DN PMID20462760C22 DMQFKBI MI TTHOI91 DMQFKBI MN NIMA-related kinase 6 (NEK6) DMQFKBI MT DTT DMQFKBI MA Inhibitor DMQFKBI RN Substituted 2H-isoquinolin-1-one as potent Rho-Kinase inhibitors. Part 1: Hit-to-lead account. Bioorg Med Chem Lett. 2010 Jun 1;20(11):3235-9. DMQFKBI RU https://pubmed.ncbi.nlm.nih.gov/20462760 DMQFKBI DI DMQFKBI DMQFKBI DN PMID20462760C22 DMQFKBI MI TTJ5SWP DMQFKBI MN NIMA-related kinase 7 (NEK7) DMQFKBI MT DTT DMQFKBI MA Inhibitor DMQFKBI RN Substituted 2H-isoquinolin-1-one as potent Rho-Kinase inhibitors. Part 1: Hit-to-lead account. Bioorg Med Chem Lett. 2010 Jun 1;20(11):3235-9. DMQFKBI RU https://pubmed.ncbi.nlm.nih.gov/20462760 DMQFKBI DI DMQFKBI DMQFKBI DN PMID20462760C22 DMQFKBI MI TTZN7RP DMQFKBI MN Rho-associated protein kinase 1 (ROCK1) DMQFKBI MT DTT DMQFKBI MA Inhibitor DMQFKBI RN Substituted 2H-isoquinolin-1-one as potent Rho-Kinase inhibitors. Part 1: Hit-to-lead account. Bioorg Med Chem Lett. 2010 Jun 1;20(11):3235-9. DMQFKBI RU https://pubmed.ncbi.nlm.nih.gov/20462760 DMQFKBI DI DMQFKBI DMQFKBI DN PMID20462760C22 DMQFKBI MI TTGWKQJ DMQFKBI MN Rho-associated protein kinase 2 (ROCK2) DMQFKBI MT DTT DMQFKBI MA Inhibitor DMQFKBI RN Substituted 2H-isoquinolin-1-one as potent Rho-Kinase inhibitors. Part 1: Hit-to-lead account. Bioorg Med Chem Lett. 2010 Jun 1;20(11):3235-9. DMQFKBI RU https://pubmed.ncbi.nlm.nih.gov/20462760 DMBQAKO DI DMBQAKO DMBQAKO DN PMID20471253C32 DMBQAKO MI TTDWFCQ DMBQAKO MN Protein kinase G2 (PRKG2) DMBQAKO MT DTT DMBQAKO MA Inhibitor DMBQAKO RN Substituted 2H-isoquinolin-1-ones as potent Rho-kinase inhibitors: part 3, aryl substituted pyrrolidines. Bioorg Med Chem Lett. 2010 Jun 15;20(12):3746-9. DMBQAKO RU https://pubmed.ncbi.nlm.nih.gov/20471253 DMBQAKO DI DMBQAKO DMBQAKO DN PMID20471253C32 DMBQAKO MI TTTHO0M DMBQAKO MN Protein kinase N2 (PKN2) DMBQAKO MT DTT DMBQAKO MA Inhibitor DMBQAKO RN Substituted 2H-isoquinolin-1-ones as potent Rho-kinase inhibitors: part 3, aryl substituted pyrrolidines. Bioorg Med Chem Lett. 2010 Jun 15;20(12):3746-9. DMBQAKO RU https://pubmed.ncbi.nlm.nih.gov/20471253 DMBQAKO DI DMBQAKO DMBQAKO DN PMID20471253C32 DMBQAKO MI TTGWKQJ DMBQAKO MN Rho-associated protein kinase 2 (ROCK2) DMBQAKO MT DTT DMBQAKO MA Inhibitor DMBQAKO RN Substituted 2H-isoquinolin-1-ones as potent Rho-kinase inhibitors: part 3, aryl substituted pyrrolidines. Bioorg Med Chem Lett. 2010 Jun 15;20(12):3746-9. DMBQAKO RU https://pubmed.ncbi.nlm.nih.gov/20471253 DMQ918T DI DMQ918T DMQ918T DN PMID20483621C5g DMQ918T MI TTPMQSO DMQ918T MN ALK tyrosine kinase receptor (ALK) DMQ918T MT DTT DMQ918T MA Inhibitor DMQ918T RN Synthesis and structure-activity relationships of 1,2,3,4-tetrahydropyrido[2,3-b]pyrazines as potent and selective inhibitors of the anaplastic lymphoma kinase. Bioorg Med Chem. 2010 Jun 15;18(12):4351-62. DMQ918T RU https://pubmed.ncbi.nlm.nih.gov/20483621 DMQ918T DI DMQ918T DMQ918T DN PMID20483621C5g DMQ918T MI TTOHTCY DMQ918T MN Doublecortin-like kinase 1 (DCLK1) DMQ918T MT DTT DMQ918T MA Inhibitor DMQ918T RN Synthesis and structure-activity relationships of 1,2,3,4-tetrahydropyrido[2,3-b]pyrazines as potent and selective inhibitors of the anaplastic lymphoma kinase. Bioorg Med Chem. 2010 Jun 15;18(12):4351-62. DMQ918T RU https://pubmed.ncbi.nlm.nih.gov/20483621 DML6OZR DI DML6OZR DML6OZR DN PMID20483621C5m DML6OZR MI TTPMQSO DML6OZR MN ALK tyrosine kinase receptor (ALK) DML6OZR MT DTT DML6OZR MA Inhibitor DML6OZR RN Synthesis and structure-activity relationships of 1,2,3,4-tetrahydropyrido[2,3-b]pyrazines as potent and selective inhibitors of the anaplastic lymphoma kinase. Bioorg Med Chem. 2010 Jun 15;18(12):4351-62. DML6OZR RU https://pubmed.ncbi.nlm.nih.gov/20483621 DML6OZR DI DML6OZR DML6OZR DN PMID20483621C5m DML6OZR MI TT32VXH DML6OZR MN BMP-2-inducible protein kinase (BMP2K) DML6OZR MT DTT DML6OZR MA Inhibitor DML6OZR RN Synthesis and structure-activity relationships of 1,2,3,4-tetrahydropyrido[2,3-b]pyrazines as potent and selective inhibitors of the anaplastic lymphoma kinase. Bioorg Med Chem. 2010 Jun 15;18(12):4351-62. DML6OZR RU https://pubmed.ncbi.nlm.nih.gov/20483621 DM2BUKP DI DM2BUKP DM2BUKP DN PMID20483621C5n DM2BUKP MI TTPMQSO DM2BUKP MN ALK tyrosine kinase receptor (ALK) DM2BUKP MT DTT DM2BUKP MA Inhibitor DM2BUKP RN Synthesis and structure-activity relationships of 1,2,3,4-tetrahydropyrido[2,3-b]pyrazines as potent and selective inhibitors of the anaplastic lymphoma kinase. Bioorg Med Chem. 2010 Jun 15;18(12):4351-62. DM2BUKP RU https://pubmed.ncbi.nlm.nih.gov/20483621 DM2BUKP DI DM2BUKP DM2BUKP DN PMID20483621C5n DM2BUKP MI TTMYK4Z DM2BUKP MN Doublecortin-like kinase 3 (DCLK3) DM2BUKP MT DTT DM2BUKP MA Inhibitor DM2BUKP RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2007). DM2BUKP RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2007 DM2BUKP DI DM2BUKP DM2BUKP DN PMID20483621C5n DM2BUKP MI TTE7RCU DM2BUKP MN MAPK/ERK kinase kinase 3 (MAP3K3) DM2BUKP MT DTT DM2BUKP MA Inhibitor DM2BUKP RN Synthesis and structure-activity relationships of 1,2,3,4-tetrahydropyrido[2,3-b]pyrazines as potent and selective inhibitors of the anaplastic lymphoma kinase. Bioorg Med Chem. 2010 Jun 15;18(12):4351-62. DM2BUKP RU https://pubmed.ncbi.nlm.nih.gov/20483621 DMI30V7 DI DMI30V7 DMI30V7 DN PMID20527968-compound-6577871 DMI30V7 MI TTRGHB2 DMI30V7 MN SARS-CoV papain-like proteinase (PL-PRO) DMI30V7 MT DTT DMI30V7 MA Inhibitor DMI30V7 RN Severe acute respiratory syndrome coronavirus papain-like novel protease inhibitors: design, synthesis, protein-ligand X-ray structure and biologic... J Med Chem. 2010 Jul 8;53(13):4968-79. DMI30V7 RU https://pubmed.ncbi.nlm.nih.gov/20527968 DMS21ZP DI DMS21ZP DMS21ZP DN PMID20598884C8 DMS21ZP MI TTHS256 DMS21ZP MN Metabotropic glutamate receptor 5 (mGluR5) DMS21ZP MT DTT DMS21ZP MA Modulator (allosteric modulator) DMS21ZP RN 3-Cyano-5-fluoro-N-arylbenzamides as negative allosteric modulators of mGlu(5): Identification of easily prepared tool compounds with CNS exposure ... Bioorg Med Chem Lett. 2010 Aug 1;20(15):4390-4. DMS21ZP RU https://pubmed.ncbi.nlm.nih.gov/20598884 DMN2HXL DI DMN2HXL DMN2HXL DN PMID20615702C8f DMN2HXL MI TTWNV8U DMN2HXL MN Nicotinic acid receptor (HCAR2) DMN2HXL MT DTT DMN2HXL MA Agonist DMN2HXL RN GPR109a agonists. Part 2: pyrazole-acids as agonists of the human orphan G-protein coupled receptor GPR109a. Bioorg Med Chem Lett. 2010 Aug 1;20(15):4472-4. DMN2HXL RU https://pubmed.ncbi.nlm.nih.gov/20615702 DMFHS4V DI DMFHS4V DMFHS4V DN PMID20638279C11 DMFHS4V MI TTICZ1O DMFHS4V MN Metabotropic glutamate receptor 4 (mGluR4) DMFHS4V MT DTT DMFHS4V MA Modulator (allosteric modulator) DMFHS4V RN An orally bioavailable positive allosteric modulator of the mGlu4 receptor with efficacy in an animal model of motor dysfunction. Bioorg Med Chem Lett. 2010 Aug 15;20(16):4901-5. DMFHS4V RU https://pubmed.ncbi.nlm.nih.gov/20638279 DMKFJP2 DI DMKFJP2 DMKFJP2 DN PMID20638279C7 DMKFJP2 MI TTICZ1O DMKFJP2 MN Metabotropic glutamate receptor 4 (mGluR4) DMKFJP2 MT DTT DMKFJP2 MA Modulator (allosteric modulator) DMKFJP2 RN An orally bioavailable positive allosteric modulator of the mGlu4 receptor with efficacy in an animal model of motor dysfunction. Bioorg Med Chem Lett. 2010 Aug 15;20(16):4901-5. DMKFJP2 RU https://pubmed.ncbi.nlm.nih.gov/20638279 DMWZK9U DI DMWZK9U DMWZK9U DN PMID20684603C24dd DMWZK9U MI TTDIGC1 DMWZK9U MN Dipeptidyl peptidase 4 (DPP-4) DMWZK9U MT DTT DMWZK9U MA Inhibitor DMWZK9U RN Discovery of 6-(aminomethyl)-5-(2,4-dichlorophenyl)-7-methylimidazo[1,2-a]pyrimidine-2-carboxamides as potent, selective dipeptidyl peptidase-4 (DPP4) inhibitors. J Med Chem. 2010 Aug 12;53(15):5620-8. DMWZK9U RU https://pubmed.ncbi.nlm.nih.gov/20684603 DMWZK9U DI DMWZK9U DMWZK9U DN PMID20684603C24dd DMWZK9U MI TTJGLZF DMWZK9U MN Dipeptidyl peptidase 8 (DPP-8) DMWZK9U MT DTT DMWZK9U MA Inhibitor DMWZK9U RN Discovery of 6-(aminomethyl)-5-(2,4-dichlorophenyl)-7-methylimidazo[1,2-a]pyrimidine-2-carboxamides as potent, selective dipeptidyl peptidase-4 (DPP4) inhibitors. J Med Chem. 2010 Aug 12;53(15):5620-8. DMWZK9U RU https://pubmed.ncbi.nlm.nih.gov/20684603 DMWZK9U DI DMWZK9U DMWZK9U DN PMID20684603C24dd DMWZK9U MI TTNDUL7 DMWZK9U MN Dipeptidyl peptidase 9 (DPP-9) DMWZK9U MT DTT DMWZK9U MA Inhibitor DMWZK9U RN Discovery of 6-(aminomethyl)-5-(2,4-dichlorophenyl)-7-methylimidazo[1,2-a]pyrimidine-2-carboxamides as potent, selective dipeptidyl peptidase-4 (DPP4) inhibitors. J Med Chem. 2010 Aug 12;53(15):5620-8. DMWZK9U RU https://pubmed.ncbi.nlm.nih.gov/20684603 DMVUEZI DI DMVUEZI DMVUEZI DN PMID20684608C35 DMVUEZI MI TTML7FG DMVUEZI MN Large tumor suppressor homolog 2 (LATS2) DMVUEZI MT DTT DMVUEZI MA Inhibitor DMVUEZI RN Tetrahydroisoquinoline derivatives as highly selective and potent Rho kinase inhibitors. J Med Chem. 2010 Aug 12;53(15):5727-37. DMVUEZI RU https://pubmed.ncbi.nlm.nih.gov/20684608 DMVUEZI DI DMVUEZI DMVUEZI DN PMID20684608C35 DMVUEZI MI TT27XFN DMVUEZI MN NDR1 protein kinase (STK38) DMVUEZI MT DTT DMVUEZI MA Inhibitor DMVUEZI RN Tetrahydroisoquinoline derivatives as highly selective and potent Rho kinase inhibitors. J Med Chem. 2010 Aug 12;53(15):5727-37. DMVUEZI RU https://pubmed.ncbi.nlm.nih.gov/20684608 DMVUEZI DI DMVUEZI DMVUEZI DN PMID20684608C35 DMVUEZI MI TTZN7RP DMVUEZI MN Rho-associated protein kinase 1 (ROCK1) DMVUEZI MT DTT DMVUEZI MA Inhibitor DMVUEZI RN Tetrahydroisoquinoline derivatives as highly selective and potent Rho kinase inhibitors. J Med Chem. 2010 Aug 12;53(15):5727-37. DMVUEZI RU https://pubmed.ncbi.nlm.nih.gov/20684608 DMVUEZI DI DMVUEZI DMVUEZI DN PMID20684608C35 DMVUEZI MI TTGWKQJ DMVUEZI MN Rho-associated protein kinase 2 (ROCK2) DMVUEZI MT DTT DMVUEZI MA Inhibitor DMVUEZI RN Tetrahydroisoquinoline derivatives as highly selective and potent Rho kinase inhibitors. J Med Chem. 2010 Aug 12;53(15):5727-37. DMVUEZI RU https://pubmed.ncbi.nlm.nih.gov/20684608 DMKVONZ DI DMKVONZ DMKVONZ DN PMID20690647C4b DMKVONZ MI TTG5QB7 DMKVONZ MN Calpain-2 (CAPN2) DMKVONZ MT DTT DMKVONZ MA Inhibitor DMKVONZ RN Peptidyl alpha-ketoamides with nucleobases, methylpiperazine, and dimethylaminoalkyl substituents as calpain inhibitors. J Med Chem. 2010 Sep 9;53(17):6326-36. DMKVONZ RU https://pubmed.ncbi.nlm.nih.gov/20690647 DMRWZX6 DI DMRWZX6 DMRWZX6 DN PMID20690647C5a DMRWZX6 MI TTG5QB7 DMRWZX6 MN Calpain-2 (CAPN2) DMRWZX6 MT DTT DMRWZX6 MA Inhibitor DMRWZX6 RN Peptidyl alpha-ketoamides with nucleobases, methylpiperazine, and dimethylaminoalkyl substituents as calpain inhibitors. J Med Chem. 2010 Sep 9;53(17):6326-36. DMRWZX6 RU https://pubmed.ncbi.nlm.nih.gov/20690647 DM0W6C9 DI DM0W6C9 DM0W6C9 DN PMID20809633C29b DM0W6C9 MI TTHS256 DM0W6C9 MN Metabotropic glutamate receptor 5 (mGluR5) DM0W6C9 MT DTT DM0W6C9 MA Modulator (allosteric modulator) DM0W6C9 RN Design, synthesis, and structure-activity relationships of novel bicyclic azole-amines as negative allosteric modulators of metabotropic glutamate receptor 5. J Med Chem. 2010 Oct 14;53(19):7107-18. DM0W6C9 RU https://pubmed.ncbi.nlm.nih.gov/20809633 DMNEB6J DI DMNEB6J DMNEB6J DN PMID20855207C25 DMNEB6J MI TT9RTBL DMNEB6J MN Aurora B messenger RNA (AURKB mRNA) DMNEB6J MT DTT DMNEB6J MA Inhibitor DMNEB6J RN Discovery of orally bioavailable imidazo[1,2-a]pyrazine-based Aurora kinase inhibitors. Bioorg Med Chem Lett. 2010 Nov 15;20(22):6739-43. DMNEB6J RU https://pubmed.ncbi.nlm.nih.gov/20855207 DMNEB6J DI DMNEB6J DMNEB6J DN PMID20855207C25 DMNEB6J MI TTLYXIT DMNEB6J MN Aurora kinase C (AURKC) DMNEB6J MT DTT DMNEB6J MA Inhibitor DMNEB6J RN Discovery of orally bioavailable imidazo[1,2-a]pyrazine-based Aurora kinase inhibitors. Bioorg Med Chem Lett. 2010 Nov 15;20(22):6739-43. DMNEB6J RU https://pubmed.ncbi.nlm.nih.gov/20855207 DMNEB6J DI DMNEB6J DMNEB6J DN PMID20855207C25 DMNEB6J MI TTTU902 DMNEB6J MN Checkpoint kinase-1 (CHK1) DMNEB6J MT DTT DMNEB6J MA Inhibitor DMNEB6J RN Discovery of orally bioavailable imidazo[1,2-a]pyrazine-based Aurora kinase inhibitors. Bioorg Med Chem Lett. 2010 Nov 15;20(22):6739-43. DMNEB6J RU https://pubmed.ncbi.nlm.nih.gov/20855207 DMVHR3Z DI DMVHR3Z DMVHR3Z DN PMID20873740C18 DMVHR3Z MI TTSMTDI DMVHR3Z MN CDC7-related kinase (CDC7) DMVHR3Z MT DTT DMVHR3Z MA Inhibitor DMVHR3Z RN Cdc7 kinase inhibitors: 5-heteroaryl-3-carboxamido-2-aryl pyrroles as potential antitumor agents. 1. Lead finding. J Med Chem. 2010 Oct 28;53(20):7296-315. DMVHR3Z RU https://pubmed.ncbi.nlm.nih.gov/20873740 DMVHR3Z DI DMVHR3Z DMVHR3Z DN PMID20873740C18 DMVHR3Z MI TT1LVF2 DMVHR3Z MN Cyclin-dependent kinase 9 (CDK9) DMVHR3Z MT DTT DMVHR3Z MA Inhibitor DMVHR3Z RN Cdc7 kinase inhibitors: 5-heteroaryl-3-carboxamido-2-aryl pyrroles as potential antitumor agents. 1. Lead finding. J Med Chem. 2010 Oct 28;53(20):7296-315. DMVHR3Z RU https://pubmed.ncbi.nlm.nih.gov/20873740 DMVHR3Z DI DMVHR3Z DMVHR3Z DN PMID20873740C18 DMVHR3Z MI TTQY9DH DMVHR3Z MN TAO kinase 1 (TAOK1) DMVHR3Z MT DTT DMVHR3Z MA Inhibitor DMVHR3Z RN Cdc7 kinase inhibitors: 5-heteroaryl-3-carboxamido-2-aryl pyrroles as potential antitumor agents. 1. Lead finding. J Med Chem. 2010 Oct 28;53(20):7296-315. DMVHR3Z RU https://pubmed.ncbi.nlm.nih.gov/20873740 DMUGWO6 DI DMUGWO6 DMUGWO6 DN PMID20936789C31 DMUGWO6 MI TTO5QT2 DMUGWO6 MN NIMA-related kinase 1 (NEK1) DMUGWO6 MT DTT DMUGWO6 MA Inhibitor DMUGWO6 RN Aminopyrazine inhibitors binding to an unusual inactive conformation of the mitotic kinase Nek2: SAR and structural characterization. J Med Chem. 2010 Nov 11;53(21):7682-98. DMUGWO6 RU https://pubmed.ncbi.nlm.nih.gov/20936789 DMUGWO6 DI DMUGWO6 DMUGWO6 DN PMID20936789C31 DMUGWO6 MI TT3VZ24 DMUGWO6 MN NIMA-related kinase 2 (NEK2) DMUGWO6 MT DTT DMUGWO6 MA Inhibitor DMUGWO6 RN Aminopyrazine inhibitors binding to an unusual inactive conformation of the mitotic kinase Nek2: SAR and structural characterization. J Med Chem. 2010 Nov 11;53(21):7682-98. DMUGWO6 RU https://pubmed.ncbi.nlm.nih.gov/20936789 DM02YSE DI DM02YSE DM02YSE DN PMID20947351C16 DM02YSE MI TT5ZKDI DM02YSE MN Histone deacetylase 6 (HDAC6) DM02YSE MT DTT DM02YSE MA Inhibitor DM02YSE RN Inhibitors selective for HDAC6 in enzymes and cells. Bioorg Med Chem Lett. 2010 Dec 1;20(23):7067-70. DM02YSE RU https://pubmed.ncbi.nlm.nih.gov/20947351 DMVPW1G DI DMVPW1G DMVPW1G DN PMID21123062C27 DMVPW1G MI TTNM4ZH DMVPW1G MN NDR2 protein kinase (STK38L) DMVPW1G MT DTT DMVPW1G MA Inhibitor DMVPW1G RN Fused bicyclic derivatives of 2,4-diaminopyrimidine as c-Met inhibitors. Bioorg Med Chem Lett. 2011 Jan 1;21(1):164-7. DMVPW1G RU https://pubmed.ncbi.nlm.nih.gov/21123062 DMVPW1G DI DMVPW1G DMVPW1G DN PMID21123062C27 DMVPW1G MI TTNDSF4 DMVPW1G MN Proto-oncogene c-Met (MET) DMVPW1G MT DTT DMVPW1G MA Inhibitor DMVPW1G RN Fused bicyclic derivatives of 2,4-diaminopyrimidine as c-Met inhibitors. Bioorg Med Chem Lett. 2011 Jan 1;21(1):164-7. DMVPW1G RU https://pubmed.ncbi.nlm.nih.gov/21123062 DMVPW1G DI DMVPW1G DMVPW1G DN PMID21123062C27 DMVPW1G MI TTFGN19 DMVPW1G MN TGF-beta-stimulated factor 1 (STK16) DMVPW1G MT DTT DMVPW1G MA Inhibitor DMVPW1G RN Fused bicyclic derivatives of 2,4-diaminopyrimidine as c-Met inhibitors. Bioorg Med Chem Lett. 2011 Jan 1;21(1):164-7. DMVPW1G RU https://pubmed.ncbi.nlm.nih.gov/21123062 DM7I341 DI DM7I341 DM7I341 DN PMID21155570C14 DM7I341 MI TTXJ47W DM7I341 MN Metabotropic glutamate receptor 2 (mGluR2) DM7I341 MT DTT DM7I341 MA Modulator (allosteric modulator) DM7I341 RN Design and synthesis of an orally active metabotropic glutamate receptor subtype-2 (mGluR2) positive allosteric modulator (PAM) that decreases cocaine self-administration in rats. J Med Chem. 2011 Jan 13;54(1):342-53. DM7I341 RU https://pubmed.ncbi.nlm.nih.gov/21155570 DM1BQY3 DI DM1BQY3 DM1BQY3 DN PMID21185185C21 DM1BQY3 MI TTWNV8U DM1BQY3 MN Nicotinic acid receptor (HCAR2) DM1BQY3 MT DTT DM1BQY3 MA Agonist DM1BQY3 RN The discovery of high affinity agonists of GPR109a with reduced serum shift and improved ADME properties. Bioorg Med Chem Lett. 2011 May 1;21(9):2721-4. DM1BQY3 RU https://pubmed.ncbi.nlm.nih.gov/21185185 DMEFUZW DI DMEFUZW DMEFUZW DN PMID21273063C1 DMEFUZW MI TT7QNVC DMEFUZW MN Glucose-dependent insulinotropic receptor (GPR119) DMEFUZW MT DTT DMEFUZW MA Agonist DMEFUZW RN Design of potent and selective GPR119 agonists for type II diabetes. Bioorg Med Chem Lett. 2011 May 1;21(9):2665-9. DMEFUZW RU https://pubmed.ncbi.nlm.nih.gov/21273063 DMFYJ6O DI DMFYJ6O DMFYJ6O DN PMID21273063C36 DMFYJ6O MI TT7QNVC DMFYJ6O MN Glucose-dependent insulinotropic receptor (GPR119) DMFYJ6O MT DTT DMFYJ6O MA Agonist DMFYJ6O RN Design of potent and selective GPR119 agonists for type II diabetes. Bioorg Med Chem Lett. 2011 May 1;21(9):2665-9. DMFYJ6O RU https://pubmed.ncbi.nlm.nih.gov/21273063 DMDCUYB DI DMDCUYB DMDCUYB DN PMID21273063C58 DMDCUYB MI TT7QNVC DMDCUYB MN Glucose-dependent insulinotropic receptor (GPR119) DMDCUYB MT DTT DMDCUYB MA Agonist DMDCUYB RN Design of potent and selective GPR119 agonists for type II diabetes. Bioorg Med Chem Lett. 2011 May 1;21(9):2665-9. DMDCUYB RU https://pubmed.ncbi.nlm.nih.gov/21273063 DMYBV8Q DI DMYBV8Q DMYBV8Q DN PMID21277783C7 DMYBV8Q MI TTSD9T1 DMYBV8Q MN Cathepsin V (CTSV) DMYBV8Q MT DTT DMYBV8Q MA Inhibitor DMYBV8Q RN Acridone alkaloids as potent inhibitors of cathepsin V. Bioorg Med Chem. 2011 Feb 15;19(4):1477-81. DMYBV8Q RU https://pubmed.ncbi.nlm.nih.gov/21277783 DM0DNSV DI DM0DNSV DM0DNSV DN PMID21295468C47 DM0DNSV MI TTHS256 DM0DNSV MN Metabotropic glutamate receptor 5 (mGluR5) DM0DNSV MT DTT DM0DNSV MA Modulator (allosteric modulator) DM0DNSV RN Discovery of novel positive allosteric modulators of the metabotropic glutamate receptor 5 (mGlu5). Bioorg Med Chem Lett. 2011 Mar 1;21(5):1402-6. DM0DNSV RU https://pubmed.ncbi.nlm.nih.gov/21295468 DMTOM3E DI DMTOM3E DMTOM3E DN PMID21310611C3 DMTOM3E MI TT7QNVC DMTOM3E MN Glucose-dependent insulinotropic receptor (GPR119) DMTOM3E MT DTT DMTOM3E MA Agonist DMTOM3E RN Design and evaluation of a 2-(2,3,6-trifluorophenyl)acetamide derivative as an agonist of the GPR119 receptor. Bioorg Med Chem Lett. 2011 Mar 1;21(5):1306-9. DMTOM3E RU https://pubmed.ncbi.nlm.nih.gov/21310611 DM9YVPU DI DM9YVPU DM9YVPU DN PMID21444206C23 DM9YVPU MI TT7QNVC DM9YVPU MN Glucose-dependent insulinotropic receptor (GPR119) DM9YVPU MT DTT DM9YVPU MA Agonist DM9YVPU RN Discovery of fused bicyclic agonists of the orphan G-protein coupled receptor GPR119 with in vivo activity in rodent models of glucose control. Bioorg Med Chem Lett. 2011 May 15;21(10):3134-41. DM9YVPU RU https://pubmed.ncbi.nlm.nih.gov/21444206 DMN50B9 DI DMN50B9 DMN50B9 DN PMID21444206C3a DMN50B9 MI TT7QNVC DMN50B9 MN Glucose-dependent insulinotropic receptor (GPR119) DMN50B9 MT DTT DMN50B9 MA Agonist DMN50B9 RN Discovery of fused bicyclic agonists of the orphan G-protein coupled receptor GPR119 with in vivo activity in rodent models of glucose control. Bioorg Med Chem Lett. 2011 May 15;21(10):3134-41. DMN50B9 RU https://pubmed.ncbi.nlm.nih.gov/21444206 DMM1YBE DI DMM1YBE DMM1YBE DN PMID21444206C3j DMM1YBE MI TT7QNVC DMM1YBE MN Glucose-dependent insulinotropic receptor (GPR119) DMM1YBE MT DTT DMM1YBE MA Agonist DMM1YBE RN Discovery of fused bicyclic agonists of the orphan G-protein coupled receptor GPR119 with in vivo activity in rodent models of glucose control. Bioorg Med Chem Lett. 2011 May 15;21(10):3134-41. DMM1YBE RU https://pubmed.ncbi.nlm.nih.gov/21444206 DMR21YD DI DMR21YD DMR21YD DN PMID21444206C8g DMR21YD MI TT7QNVC DMR21YD MN Glucose-dependent insulinotropic receptor (GPR119) DMR21YD MT DTT DMR21YD MA Agonist DMR21YD RN Discovery of fused bicyclic agonists of the orphan G-protein coupled receptor GPR119 with in vivo activity in rodent models of glucose control. Bioorg Med Chem Lett. 2011 May 15;21(10):3134-41. DMR21YD RU https://pubmed.ncbi.nlm.nih.gov/21444206 DMFUQIT DI DMFUQIT DMFUQIT DN PMID21493067C1d DMFUQIT MI TTST7KB DMFUQIT MN Fibroblast growth factor receptor 3 (FGFR3) DMFUQIT MT DTT DMFUQIT MA Inhibitor DMFUQIT RN In vitro and in vivo evaluation of 6-aminopyrazolyl-pyridine-3-carbonitriles as JAK2 kinase inhibitors. Bioorg Med Chem Lett. 2011 May 15;21(10):2958-61. DMFUQIT RU https://pubmed.ncbi.nlm.nih.gov/21493067 DMFUQIT DI DMFUQIT DMFUQIT DN PMID21493067C1d DMFUQIT MI TTRMX3V DMFUQIT MN Janus kinase 2 (JAK-2) DMFUQIT MT DTT DMFUQIT MA Inhibitor DMFUQIT RN In vitro and in vivo evaluation of 6-aminopyrazolyl-pyridine-3-carbonitriles as JAK2 kinase inhibitors. Bioorg Med Chem Lett. 2011 May 15;21(10):2958-61. DMFUQIT RU https://pubmed.ncbi.nlm.nih.gov/21493067 DMFUQIT DI DMFUQIT DMFUQIT DN PMID21493067C1d DMFUQIT MI TTT7PJU DMFUQIT MN Janus kinase 3 (JAK-3) DMFUQIT MT DTT DMFUQIT MA Inhibitor DMFUQIT RN In vitro and in vivo evaluation of 6-aminopyrazolyl-pyridine-3-carbonitriles as JAK2 kinase inhibitors. Bioorg Med Chem Lett. 2011 May 15;21(10):2958-61. DMFUQIT RU https://pubmed.ncbi.nlm.nih.gov/21493067 DMFUQIT DI DMFUQIT DMFUQIT DN PMID21493067C1d DMFUQIT MI TT6SA0X DMFUQIT MN Muscle-specific kinase receptor (MUSK) DMFUQIT MT DTT DMFUQIT MA Inhibitor DMFUQIT RN In vitro and in vivo evaluation of 6-aminopyrazolyl-pyridine-3-carbonitriles as JAK2 kinase inhibitors. Bioorg Med Chem Lett. 2011 May 15;21(10):2958-61. DMFUQIT RU https://pubmed.ncbi.nlm.nih.gov/21493067 DMFUQIT DI DMFUQIT DMFUQIT DN PMID21493067C1d DMFUQIT MI TTXABCW DMFUQIT MN NT-3 growth factor receptor (TrkC) DMFUQIT MT DTT DMFUQIT MA Inhibitor DMFUQIT RN In vitro and in vivo evaluation of 6-aminopyrazolyl-pyridine-3-carbonitriles as JAK2 kinase inhibitors. Bioorg Med Chem Lett. 2011 May 15;21(10):2958-61. DMFUQIT RU https://pubmed.ncbi.nlm.nih.gov/21493067 DMFUQIT DI DMFUQIT DMFUQIT DN PMID21493067C1d DMFUQIT MI TT4DXQT DMFUQIT MN Proto-oncogene c-Ret (RET) DMFUQIT MT DTT DMFUQIT MA Inhibitor DMFUQIT RN In vitro and in vivo evaluation of 6-aminopyrazolyl-pyridine-3-carbonitriles as JAK2 kinase inhibitors. Bioorg Med Chem Lett. 2011 May 15;21(10):2958-61. DMFUQIT RU https://pubmed.ncbi.nlm.nih.gov/21493067 DMUMYTB DI DMUMYTB DMUMYTB DN PMID2153213C13b DMUMYTB MI TTPADOQ DMUMYTB MN HMG-CoA reductase (HMGCR) DMUMYTB MT DTT DMUMYTB MA Inhibitor DMUMYTB RN Synthesis and biological activity of new HMG-CoA reductase inhibitors. 2. Derivatives of 7-(1H-pyrrol-3-yl)-substituted-3,5-dihydroxyhept-6(E)-enoic (-heptanoic) acids. J Med Chem. 1990 Jan;33(1):61-70. DMUMYTB RU https://pubmed.ncbi.nlm.nih.gov/2153213 DM5TL2S DI DM5TL2S DM5TL2S DN PMID2153213C13g DM5TL2S MI TTPADOQ DM5TL2S MN HMG-CoA reductase (HMGCR) DM5TL2S MT DTT DM5TL2S MA Inhibitor DM5TL2S RN Synthesis and biological activity of new HMG-CoA reductase inhibitors. 2. Derivatives of 7-(1H-pyrrol-3-yl)-substituted-3,5-dihydroxyhept-6(E)-enoic (-heptanoic) acids. J Med Chem. 1990 Jan;33(1):61-70. DM5TL2S RU https://pubmed.ncbi.nlm.nih.gov/2153213 DMVYB6Q DI DMVYB6Q DMVYB6Q DN PMID2153213C1a DMVYB6Q MI TTPADOQ DMVYB6Q MN HMG-CoA reductase (HMGCR) DMVYB6Q MT DTT DMVYB6Q MA Inhibitor DMVYB6Q RN Synthesis and biological activity of new HMG-CoA reductase inhibitors. 2. Derivatives of 7-(1H-pyrrol-3-yl)-substituted-3,5-dihydroxyhept-6(E)-enoic (-heptanoic) acids. J Med Chem. 1990 Jan;33(1):61-70. DMVYB6Q RU https://pubmed.ncbi.nlm.nih.gov/2153213 DMRUJFZ DI DMRUJFZ DMRUJFZ DN PMID2153213C1e DMRUJFZ MI TTPADOQ DMRUJFZ MN HMG-CoA reductase (HMGCR) DMRUJFZ MT DTT DMRUJFZ MA Inhibitor DMRUJFZ RN Synthesis and biological activity of new HMG-CoA reductase inhibitors. 2. Derivatives of 7-(1H-pyrrol-3-yl)-substituted-3,5-dihydroxyhept-6(E)-enoic (-heptanoic) acids. J Med Chem. 1990 Jan;33(1):61-70. DMRUJFZ RU https://pubmed.ncbi.nlm.nih.gov/2153213 DMOLIE1 DI DMOLIE1 DMOLIE1 DN PMID2153213C1f DMOLIE1 MI TTPADOQ DMOLIE1 MN HMG-CoA reductase (HMGCR) DMOLIE1 MT DTT DMOLIE1 MA Inhibitor DMOLIE1 RN Synthesis and biological activity of new HMG-CoA reductase inhibitors. 2. Derivatives of 7-(1H-pyrrol-3-yl)-substituted-3,5-dihydroxyhept-6(E)-enoic (-heptanoic) acids. J Med Chem. 1990 Jan;33(1):61-70. DMOLIE1 RU https://pubmed.ncbi.nlm.nih.gov/2153213 DMJ4126 DI DMJ4126 DMJ4126 DN PMID2153213C2c DMJ4126 MI TTPADOQ DMJ4126 MN HMG-CoA reductase (HMGCR) DMJ4126 MT DTT DMJ4126 MA Inhibitor DMJ4126 RN Synthesis and biological activity of new HMG-CoA reductase inhibitors. 2. Derivatives of 7-(1H-pyrrol-3-yl)-substituted-3,5-dihydroxyhept-6(E)-enoic (-heptanoic) acids. J Med Chem. 1990 Jan;33(1):61-70. DMJ4126 RU https://pubmed.ncbi.nlm.nih.gov/2153213 DMGAY4M DI DMGAY4M DMGAY4M DN PMID2153213C2d DMGAY4M MI TTPADOQ DMGAY4M MN HMG-CoA reductase (HMGCR) DMGAY4M MT DTT DMGAY4M MA Inhibitor DMGAY4M RN Synthesis and biological activity of new HMG-CoA reductase inhibitors. 2. Derivatives of 7-(1H-pyrrol-3-yl)-substituted-3,5-dihydroxyhept-6(E)-enoic (-heptanoic) acids. J Med Chem. 1990 Jan;33(1):61-70. DMGAY4M RU https://pubmed.ncbi.nlm.nih.gov/2153213 DM6QXYE DI DM6QXYE DM6QXYE DN PMID2153213C2f DM6QXYE MI TTPADOQ DM6QXYE MN HMG-CoA reductase (HMGCR) DM6QXYE MT DTT DM6QXYE MA Inhibitor DM6QXYE RN Synthesis and biological activity of new HMG-CoA reductase inhibitors. 2. Derivatives of 7-(1H-pyrrol-3-yl)-substituted-3,5-dihydroxyhept-6(E)-enoic (-heptanoic) acids. J Med Chem. 1990 Jan;33(1):61-70. DM6QXYE RU https://pubmed.ncbi.nlm.nih.gov/2153213 DM2R94W DI DM2R94W DM2R94W DN PMID21536437C15c DM2R94W MI TTXSU2Y DM2R94W MN Aggrecanase (ADAMTS5) DM2R94W MT DTT DM2R94W MA Inhibitor DM2R94W RN Orally active achiral N-hydroxyformamide inhibitors of ADAM-TS4 (aggrecanase-1) and ADAM-TS5 (aggrecanase-2) for the treatment of osteoarthritis. Bioorg Med Chem Lett. 2011 Jun 1;21(11):3301-6. DM2R94W RU https://pubmed.ncbi.nlm.nih.gov/21536437 DMHWX2O DI DMHWX2O DMHWX2O DN PMID21536438C20f DMHWX2O MI TT7QNVC DMHWX2O MN Glucose-dependent insulinotropic receptor (GPR119) DMHWX2O MT DTT DMHWX2O MA Agonist DMHWX2O RN Discovery of a nortropanol derivative as a potent and orally active GPR119 agonist for type 2 diabetes. Bioorg Med Chem Lett. 2011 Jun 1;21(11):3290-6. DMHWX2O RU https://pubmed.ncbi.nlm.nih.gov/21536438 DM06V1Q DI DM06V1Q DM06V1Q DN PMID21536438C36j DM06V1Q MI TT7QNVC DM06V1Q MN Glucose-dependent insulinotropic receptor (GPR119) DM06V1Q MT DTT DM06V1Q MA Agonist DM06V1Q RN Discovery of a nortropanol derivative as a potent and orally active GPR119 agonist for type 2 diabetes. Bioorg Med Chem Lett. 2011 Jun 1;21(11):3290-6. DM06V1Q RU https://pubmed.ncbi.nlm.nih.gov/21536438 DMABZH6 DI DMABZH6 DMABZH6 DN PMID21561767C8h DMABZH6 MI TT6B75U DMABZH6 MN ABL messenger RNA (ABL mRNA) DMABZH6 MT DTT DMABZH6 MA Inhibitor DMABZH6 RN Discovery of 5-(arenethynyl) hetero-monocyclic derivatives as potent inhibitors of BCR-ABL including the T315I gatekeeper mutant. Bioorg Med Chem Lett. 2011 Jun 15;21(12):3743-8. DMABZH6 RU https://pubmed.ncbi.nlm.nih.gov/21561767 DMABZH6 DI DMABZH6 DMABZH6 DN PMID21561767C8h DMABZH6 MI TT9VGXW DMABZH6 MN Angiopoietin 1 receptor (TEK) DMABZH6 MT DTT DMABZH6 MA Inhibitor DMABZH6 RN Discovery of 5-(arenethynyl) hetero-monocyclic derivatives as potent inhibitors of BCR-ABL including the T315I gatekeeper mutant. Bioorg Med Chem Lett. 2011 Jun 15;21(12):3743-8. DMABZH6 RU https://pubmed.ncbi.nlm.nih.gov/21561767 DMABZH6 DI DMABZH6 DMABZH6 DN PMID21561767C8h DMABZH6 MI TTRJB2G DMABZH6 MN Ephrin type-A receptor 2 (EPHA2) DMABZH6 MT DTT DMABZH6 MA Inhibitor DMABZH6 RN Discovery of 5-(arenethynyl) hetero-monocyclic derivatives as potent inhibitors of BCR-ABL including the T315I gatekeeper mutant. Bioorg Med Chem Lett. 2011 Jun 15;21(12):3743-8. DMABZH6 RU https://pubmed.ncbi.nlm.nih.gov/21561767 DMABZH6 DI DMABZH6 DMABZH6 DN PMID21561767C8h DMABZH6 MI TTHS2LR DMABZH6 MN Ephrin type-A receptor 3 (EPHA3) DMABZH6 MT DTT DMABZH6 MA Inhibitor DMABZH6 RN Discovery of 5-(arenethynyl) hetero-monocyclic derivatives as potent inhibitors of BCR-ABL including the T315I gatekeeper mutant. Bioorg Med Chem Lett. 2011 Jun 15;21(12):3743-8. DMABZH6 RU https://pubmed.ncbi.nlm.nih.gov/21561767 DMABZH6 DI DMABZH6 DMABZH6 DN PMID21561767C8h DMABZH6 MI TTAHTVG DMABZH6 MN Ephrin type-A receptor 7 (EPHA7) DMABZH6 MT DTT DMABZH6 MA Inhibitor DMABZH6 RN Discovery of 5-(arenethynyl) hetero-monocyclic derivatives as potent inhibitors of BCR-ABL including the T315I gatekeeper mutant. Bioorg Med Chem Lett. 2011 Jun 15;21(12):3743-8. DMABZH6 RU https://pubmed.ncbi.nlm.nih.gov/21561767 DMABZH6 DI DMABZH6 DMABZH6 DN PMID21561767C8h DMABZH6 MI TT8FYO9 DMABZH6 MN Platelet-derived growth factor receptor alpha (PDGFRA) DMABZH6 MT DTT DMABZH6 MA Inhibitor DMABZH6 RN Discovery of 5-(arenethynyl) hetero-monocyclic derivatives as potent inhibitors of BCR-ABL including the T315I gatekeeper mutant. Bioorg Med Chem Lett. 2011 Jun 15;21(12):3743-8. DMABZH6 RU https://pubmed.ncbi.nlm.nih.gov/21561767 DMABZH6 DI DMABZH6 DMABZH6 DN PMID21561767C8h DMABZH6 MI TT4DXQT DMABZH6 MN Proto-oncogene c-Ret (RET) DMABZH6 MT DTT DMABZH6 MA Inhibitor DMABZH6 RN Discovery of 5-(arenethynyl) hetero-monocyclic derivatives as potent inhibitors of BCR-ABL including the T315I gatekeeper mutant. Bioorg Med Chem Lett. 2011 Jun 15;21(12):3743-8. DMABZH6 RU https://pubmed.ncbi.nlm.nih.gov/21561767 DMEF8GV DI DMEF8GV DMEF8GV DN PMID21571530C5g DMEF8GV MI TT4FX9Y DMEF8GV MN Succinate receptor (SUCNR1) DMEF8GV MT DTT DMEF8GV MA Antagonist DMEF8GV RN Discovery of a potent and selective small molecule hGPR91 antagonist. Bioorg Med Chem Lett. 2011 Jun 15;21(12):3596-602. DMEF8GV RU https://pubmed.ncbi.nlm.nih.gov/21571530 DMPBITK DI DMPBITK DMPBITK DN PMID21571530C7e DMPBITK MI TT4FX9Y DMPBITK MN Succinate receptor (SUCNR1) DMPBITK MT DTT DMPBITK MA Antagonist DMPBITK RN Discovery of a potent and selective small molecule hGPR91 antagonist. Bioorg Med Chem Lett. 2011 Jun 15;21(12):3596-602. DMPBITK RU https://pubmed.ncbi.nlm.nih.gov/21571530 DM7JRHB DI DM7JRHB DM7JRHB DN PMID21596927C101 DM7JRHB MI TTAZ3MN DM7JRHB MN Beta-adrenergic receptor kinase 1 (ADRBK1) DM7JRHB MT DTT DM7JRHB MA Inhibitor DM7JRHB RN Molecular mechanism of selectivity among G protein-coupled receptor kinase 2 inhibitors. Mol Pharmacol. 2011 Aug;80(2):294-303. DM7JRHB RU https://pubmed.ncbi.nlm.nih.gov/21596927 DM7JRHB DI DM7JRHB DM7JRHB DN PMID21596927C101 DM7JRHB MI TT5A4DX DM7JRHB MN Beta-adrenergic receptor kinase 2 (ADRBK2) DM7JRHB MT DTT DM7JRHB MA Inhibitor DM7JRHB RN Molecular mechanism of selectivity among G protein-coupled receptor kinase 2 inhibitors. Mol Pharmacol. 2011 Aug;80(2):294-303. DM7JRHB RU https://pubmed.ncbi.nlm.nih.gov/21596927 DMQHAIK DI DMQHAIK DMQHAIK DN PMID21627121C2 DMQHAIK MI TT3VZ24 DMQHAIK MN NIMA-related kinase 2 (NEK2) DMQHAIK MT DTT DMQHAIK MA Inhibitor DMQHAIK RN Irreversible Nek2 kinase inhibitors with cellular activity. J Med Chem. 2011 Jun 23;54(12):4133-46. DMQHAIK RU https://pubmed.ncbi.nlm.nih.gov/21627121 DMEBM19 DI DMEBM19 DMEBM19 DN PMID21688779C22a DMEBM19 MI TTICZ1O DMEBM19 MN Metabotropic glutamate receptor 4 (mGluR4) DMEBM19 MT DTT DMEBM19 MA Modulator (allosteric modulator) DMEBM19 RN Tricyclic thiazolopyrazole derivatives as metabotropic glutamate receptor 4 positive allosteric modulators. J Med Chem. 2011 Jul 28;54(14):5070-81. DMEBM19 RU https://pubmed.ncbi.nlm.nih.gov/21688779 DMXSCEA DI DMXSCEA DMXSCEA DN PMID21692504C8 DMXSCEA MI TT3HYDO DMXSCEA MN Prolyl endopeptidase-like (PREPL) DMXSCEA MT DTT DMXSCEA MA Inhibitor DMXSCEA RN A substrate-free activity-based protein profiling screen for the discovery of selective PREPL inhibitors. J Am Chem Soc. 2011 Aug 3;133(30):11665-74. DMXSCEA RU https://pubmed.ncbi.nlm.nih.gov/21692504 DM8PA2V DI DM8PA2V DM8PA2V DN PMID21741839C5 DM8PA2V MI TTWHYC8 DM8PA2V MN Airway trypsin-like protease (TMPRSS11D) DM8PA2V MT DTT DM8PA2V MA Inhibitor DM8PA2V RN Development of substrate analogue inhibitors for the human airway trypsin-like protease HAT. Bioorg Med Chem Lett. 2011 Aug 15;21(16):4860-4. DM8PA2V RU https://pubmed.ncbi.nlm.nih.gov/21741839 DM8PA2V DI DM8PA2V DM8PA2V DN PMID21741839C5 DM8PA2V MI TT1GM2Z DM8PA2V MN Transmembrane protease serine 2 (TMPRSS2) DM8PA2V MT DTT DM8PA2V MA Inhibitor DM8PA2V RN Development of substrate analogue inhibitors for the human airway trypsin-like protease HAT. Bioorg Med Chem Lett. 2011 Aug 15;21(16):4860-4. DM8PA2V RU https://pubmed.ncbi.nlm.nih.gov/21741839 DME3JMH DI DME3JMH DME3JMH DN PMID21742770C1 DME3JMH MI TT9RTBL DME3JMH MN Aurora B messenger RNA (AURKB mRNA) DME3JMH MT DTT DME3JMH MA Inhibitor DME3JMH RN A Potent and Selective Quinoxalinone-Based STK33 Inhibitor Does Not Show Synthetic Lethality in KRAS-Dependent Cells. ACS Med Chem Lett. 2012 Dec 13;3(12):1034-1038. DME3JMH RU https://pubmed.ncbi.nlm.nih.gov/23256033 DME3JMH DI DME3JMH DME3JMH DN PMID21742770C1 DME3JMH MI TTYVI76 DME3JMH MN Fungal Protein kinase A (Fung ypkA) DME3JMH MT DTT DME3JMH MA Inhibitor DME3JMH RN A Potent and Selective Quinoxalinone-Based STK33 Inhibitor Does Not Show Synthetic Lethality in KRAS-Dependent Cells. ACS Med Chem Lett. 2012 Dec 13;3(12):1034-1038. DME3JMH RU https://pubmed.ncbi.nlm.nih.gov/23256033 DME3JMH DI DME3JMH DME3JMH DN PMID21742770C1 DME3JMH MI TTP34DQ DME3JMH MN Serine/threonine-protein kinase 33 (STK33) DME3JMH MT DTT DME3JMH MA Inhibitor DME3JMH RN STK33 kinase activity is nonessential in KRAS-dependent cancer cells. Cancer Res. 2011 Sep 1;71(17):5818-26. DME3JMH RU https://pubmed.ncbi.nlm.nih.gov/21742770 DM3ELPS DI DM3ELPS DM3ELPS DN PMID21757343C30 DM3ELPS MI TTHS256 DM3ELPS MN Metabotropic glutamate receptor 5 (mGluR5) DM3ELPS MT DTT DM3ELPS MA Modulator (allosteric modulator) DM3ELPS RN 6-Aryl-3-pyrrolidinylpyridines as mGlu5 receptor negative allosteric modulators. Bioorg Med Chem Lett. 2011 Aug 15;21(16):4891-9. DM3ELPS RU https://pubmed.ncbi.nlm.nih.gov/21757343 DM48HR9 DI DM48HR9 DM48HR9 DN PMID21802293C66 DM48HR9 MI TT7YMXZ DM48HR9 MN Tyrosine-protein kinase Srms (SRMS) DM48HR9 MT DTT DM48HR9 MA Inhibitor DM48HR9 RN Pyrazolopyridine inhibitors of B-RafV600E. Part 2: structure-activity relationships. Bioorg Med Chem Lett. 2011 Sep 15;21(18):5533-7. DM48HR9 RU https://pubmed.ncbi.nlm.nih.gov/21802293 DMXF32O DI DMXF32O DMXF32O DN PMID21823616C22 DMXF32O MI TT7ALZG DMXF32O MN Integrin-linked protein kinase 1 (ILK) DMXF32O MT DTT DMXF32O MA Inhibitor DMXF32O RN Identification and characterization of a novel integrin-linked kinase inhibitor. J Med Chem. 2011 Sep 22;54(18):6364-74. DMXF32O RU https://pubmed.ncbi.nlm.nih.gov/21823616 DMI1FGV DI DMI1FGV DMI1FGV DN PMID21851057C4d DMI1FGV MI TTDP48B DMI1FGV MN Bromodomain-containing protein 2 (BRD2) DMI1FGV MT DTT DMI1FGV MA Inhibitor DMI1FGV RN 3,5-dimethylisoxazoles act as acetyl-lysine-mimetic bromodomain ligands. J Med Chem. 2011 Oct 13;54(19):6761-70. DMI1FGV RU https://pubmed.ncbi.nlm.nih.gov/21851057 DMI1FGV DI DMI1FGV DMI1FGV DN PMID21851057C4d DMI1FGV MI TTRA6BO DMI1FGV MN Bromodomain-containing protein 4 (BRD4) DMI1FGV MT DTT DMI1FGV MA Inhibitor DMI1FGV RN 3,5-dimethylisoxazoles act as acetyl-lysine-mimetic bromodomain ligands. J Med Chem. 2011 Oct 13;54(19):6761-70. DMI1FGV RU https://pubmed.ncbi.nlm.nih.gov/21851057 DMTKJA9 DI DMTKJA9 DMTKJA9 DN PMID21855335C19a DMTKJA9 MI TT860QF DMTKJA9 MN LCK tyrosine protein kinase (LCK) DMTKJA9 MT DTT DMTKJA9 MA Inhibitor DMTKJA9 RN Discovery of novel imidazo[1,2-a]pyrazin-8-amines as Brk/PTK6 inhibitors. Bioorg Med Chem Lett. 2011 Oct 1;21(19):5870-5. DMTKJA9 RU https://pubmed.ncbi.nlm.nih.gov/21855335 DMTKJA9 DI DMTKJA9 DMTKJA9 DN PMID21855335C19a DMTKJA9 MI TT6TH8V DMTKJA9 MN Tyrosine-protein kinase BRK (PTK6) DMTKJA9 MT DTT DMTKJA9 MA Inhibitor DMTKJA9 RN Discovery of novel imidazo[1,2-a]pyrazin-8-amines as Brk/PTK6 inhibitors. Bioorg Med Chem Lett. 2011 Oct 1;21(19):5870-5. DMTKJA9 RU https://pubmed.ncbi.nlm.nih.gov/21855335 DMST0IN DI DMST0IN DMST0IN DN PMID21907142CJ DMST0IN MI TT8JRS7 DMST0IN MN Beta-secretase (BACE) DMST0IN MT DTT DMST0IN MA Inhibitor DMST0IN RN Bace2 is a beta cell-enriched protease that regulates pancreatic beta cell function and mass. Cell Metab. 2011 Sep 7;14(3):365-77. DMST0IN RU https://pubmed.ncbi.nlm.nih.gov/21907142 DMST0IN DI DMST0IN DMST0IN DN PMID21907142CJ DMST0IN MI TT69DB8 DMST0IN MN Beta-site APP-cleaving enzyme 2 (BACE2) DMST0IN MT DTT DMST0IN MA Inhibitor DMST0IN RN Bace2 is a beta cell-enriched protease that regulates pancreatic beta cell function and mass. Cell Metab. 2011 Sep 7;14(3):365-77. DMST0IN RU https://pubmed.ncbi.nlm.nih.gov/21907142 DMLGKD3 DI DMLGKD3 DMLGKD3 DN PMID21927650C18 DMLGKD3 MI TTHS256 DMLGKD3 MN Metabotropic glutamate receptor 5 (mGluR5) DMLGKD3 MT DTT DMLGKD3 MA Modulator (allosteric modulator) DMLGKD3 RN (3-Cyano-5-fluorophenyl)biaryl negative allosteric modulators of mGlu(5): Discovery of a new tool compound with activity in the OSS mouse model of addiction. ACS Chem Neurosci. 2011 Aug 17;2(8):471-482. DMLGKD3 RU https://pubmed.ncbi.nlm.nih.gov/21927650 DMEUQFG DI DMEUQFG DMEUQFG DN PMID21939274C1 DMEUQFG MI TT7QNVC DMEUQFG MN Glucose-dependent insulinotropic receptor (GPR119) DMEUQFG MT DTT DMEUQFG MA Agonist DMEUQFG RN Oxidative metabolism of a quinoxaline derivative by xanthine oxidase in rodent plasma. Chem Res Toxicol. 2011 Dec 19;24(12):2207-16. DMEUQFG RU https://pubmed.ncbi.nlm.nih.gov/21939274 DMRCAEI DI DMRCAEI DMRCAEI DN PMID21939274C2 DMRCAEI MI TT7QNVC DMRCAEI MN Glucose-dependent insulinotropic receptor (GPR119) DMRCAEI MT DTT DMRCAEI MA Agonist DMRCAEI RN Oxidative metabolism of a quinoxaline derivative by xanthine oxidase in rodent plasma. Chem Res Toxicol. 2011 Dec 19;24(12):2207-16. DMRCAEI RU https://pubmed.ncbi.nlm.nih.gov/21939274 DMCOHKU DI DMCOHKU DMCOHKU DN PMID21967808CR-16 DMCOHKU MI TTBPJOK DMCOHKU MN IL-1 receptor-associated kinase 3 (IRAK3) DMCOHKU MT DTT DMCOHKU MA Inhibitor DMCOHKU RN Improvement in oral bioavailability of 2,4-diaminopyrimidine c-Met inhibitors by incorporation of a 3-amidobenzazepin-2-one group. Bioorg Med Chem. 2011 Nov 1;19(21):6274-84. DMCOHKU RU https://pubmed.ncbi.nlm.nih.gov/21967808 DMCOHKU DI DMCOHKU DMCOHKU DN PMID21967808CR-16 DMCOHKU MI TTNDSF4 DMCOHKU MN Proto-oncogene c-Met (MET) DMCOHKU MT DTT DMCOHKU MA Inhibitor DMCOHKU RN Improvement in oral bioavailability of 2,4-diaminopyrimidine c-Met inhibitors by incorporation of a 3-amidobenzazepin-2-one group. Bioorg Med Chem. 2011 Nov 1;19(21):6274-84. DMCOHKU RU https://pubmed.ncbi.nlm.nih.gov/21967808 DMCOHKU DI DMCOHKU DMCOHKU DN PMID21967808CR-16 DMCOHKU MI TT4D7MJ DMCOHKU MN Serine/threonine-protein kinase ULK1 (ULK1) DMCOHKU MT DTT DMCOHKU MA Inhibitor DMCOHKU RN Improvement in oral bioavailability of 2,4-diaminopyrimidine c-Met inhibitors by incorporation of a 3-amidobenzazepin-2-one group. Bioorg Med Chem. 2011 Nov 1;19(21):6274-84. DMCOHKU RU https://pubmed.ncbi.nlm.nih.gov/21967808 DMCOHKU DI DMCOHKU DMCOHKU DN PMID21967808CR-16 DMCOHKU MI TTYNM3X DMCOHKU MN Sugen kinase 110 (SBK3) DMCOHKU MT DTT DMCOHKU MA Inhibitor DMCOHKU RN Improvement in oral bioavailability of 2,4-diaminopyrimidine c-Met inhibitors by incorporation of a 3-amidobenzazepin-2-one group. Bioorg Med Chem. 2011 Nov 1;19(21):6274-84. DMCOHKU RU https://pubmed.ncbi.nlm.nih.gov/21967808 DMCOHKU DI DMCOHKU DMCOHKU DN PMID21967808CR-16 DMCOHKU MI TTT4236 DMCOHKU MN Tie-1 tyrosine kinase receptor (TIE1) DMCOHKU MT DTT DMCOHKU MA Inhibitor DMCOHKU RN Improvement in oral bioavailability of 2,4-diaminopyrimidine c-Met inhibitors by incorporation of a 3-amidobenzazepin-2-one group. Bioorg Med Chem. 2011 Nov 1;19(21):6274-84. DMCOHKU RU https://pubmed.ncbi.nlm.nih.gov/21967808 DM0VOXN DI DM0VOXN DM0VOXN DN PMID21982499C14k DM0VOXN MI TT34L5N DM0VOXN MN Casein kinase I gamma-3 (CSNK1G3) DM0VOXN MT DTT DM0VOXN MA Inhibitor DM0VOXN RN 7-(4H-1,2,4-Triazol-3-yl)benzo[c][2,6]naphthyridines: a novel class of Pim kinase inhibitors with potent cell antiproliferative activity. Bioorg Med Chem Lett. 2011 Nov 15;21(22):6687-92. DM0VOXN RU https://pubmed.ncbi.nlm.nih.gov/21982499 DM0VOXN DI DM0VOXN DM0VOXN DN PMID21982499C14k DM0VOXN MI TTGJCWZ DM0VOXN MN Fms-like tyrosine kinase 3 (FLT-3) DM0VOXN MT DTT DM0VOXN MA Inhibitor DM0VOXN RN 7-(4H-1,2,4-Triazol-3-yl)benzo[c][2,6]naphthyridines: a novel class of Pim kinase inhibitors with potent cell antiproliferative activity. Bioorg Med Chem Lett. 2011 Nov 15;21(22):6687-92. DM0VOXN RU https://pubmed.ncbi.nlm.nih.gov/21982499 DM0VOXN DI DM0VOXN DM0VOXN DN PMID21982499C14k DM0VOXN MI TTCGOIN DM0VOXN MN PIM-3 protein kinase (PIM3) DM0VOXN MT DTT DM0VOXN MA Inhibitor DM0VOXN RN 7-(4H-1,2,4-Triazol-3-yl)benzo[c][2,6]naphthyridines: a novel class of Pim kinase inhibitors with potent cell antiproliferative activity. Bioorg Med Chem Lett. 2011 Nov 15;21(22):6687-92. DM0VOXN RU https://pubmed.ncbi.nlm.nih.gov/21982499 DM0VOXN DI DM0VOXN DM0VOXN DN PMID21982499C14k DM0VOXN MI TTTN5QW DM0VOXN MN Serine/threonine-protein kinase pim-1 (PIM1) DM0VOXN MT DTT DM0VOXN MA Inhibitor DM0VOXN RN 7-(4H-1,2,4-Triazol-3-yl)benzo[c][2,6]naphthyridines: a novel class of Pim kinase inhibitors with potent cell antiproliferative activity. Bioorg Med Chem Lett. 2011 Nov 15;21(22):6687-92. DM0VOXN RU https://pubmed.ncbi.nlm.nih.gov/21982499 DM0VOXN DI DM0VOXN DM0VOXN DN PMID21982499C14k DM0VOXN MI TT69J2Z DM0VOXN MN Serine/threonine-protein kinase pim-2 (PIM2) DM0VOXN MT DTT DM0VOXN MA Inhibitor DM0VOXN RN 7-(4H-1,2,4-Triazol-3-yl)benzo[c][2,6]naphthyridines: a novel class of Pim kinase inhibitors with potent cell antiproliferative activity. Bioorg Med Chem Lett. 2011 Nov 15;21(22):6687-92. DM0VOXN RU https://pubmed.ncbi.nlm.nih.gov/21982499 DMWBYNF DI DMWBYNF DMWBYNF DN PMID22017539C15 DMWBYNF MI TTHY57M DMWBYNF MN Matrix metalloproteinase-13 (MMP-13) DMWBYNF MT DTT DMWBYNF MA Inhibitor DMWBYNF RN Fragment-based discovery of indole inhibitors of matrix metalloproteinase-13. J Med Chem. 2011 Dec 8;54(23):8174-87. DMWBYNF RU https://pubmed.ncbi.nlm.nih.gov/22017539 DMX5UKA DI DMX5UKA DMX5UKA DN PMID22115617C2c DMX5UKA MI TTER6YH DMX5UKA MN Casein kinase II alpha (CSNK2A1) DMX5UKA MT DTT DMX5UKA MA Inhibitor DMX5UKA RN CK2alpha and CK2alpha' subunits differ in their sensitivity to 4,5,6,7-tetrabromo- and 4,5,6,7-tetraiodo-1H-benzimidazole derivatives. Eur J Med Chem. 2012 Jan;47(1):345-50. DMX5UKA RU https://pubmed.ncbi.nlm.nih.gov/22115617 DMX5UKA DI DMX5UKA DMX5UKA DN PMID22115617C2c DMX5UKA MI TTR93NU DMX5UKA MN Casein kinase II alpha prime (CSNK2A2) DMX5UKA MT DTT DMX5UKA MA Inhibitor DMX5UKA RN CK2alpha and CK2alpha' subunits differ in their sensitivity to 4,5,6,7-tetrabromo- and 4,5,6,7-tetraiodo-1H-benzimidazole derivatives. Eur J Med Chem. 2012 Jan;47(1):345-50. DMX5UKA RU https://pubmed.ncbi.nlm.nih.gov/22115617 DMZ5BHX DI DMZ5BHX DMZ5BHX DN PMID22123324C38 DMZ5BHX MI TTS17MG DMZ5BHX MN Melanin-concentrating hormone receptor 2 (MCHR2) DMZ5BHX MT DTT DMZ5BHX MA Antagonist DMZ5BHX RN Discovery and characterization of a potent and selective antagonist of melanin-concentrating hormone receptor 2. Bioorg Med Chem Lett. 2012 Jan 1;22(1):363-6. DMZ5BHX RU https://pubmed.ncbi.nlm.nih.gov/22123324 DMI8217 DI DMI8217 DMI8217 DN PMID22136433C20 DMI8217 MI TTV298Y DMI8217 MN Calmodulin-dependent kinase II (CAMKK2) DMI8217 MT DTT DMI8217 MA Inhibitor DMI8217 RN 7,8-dichloro-1-oxo-beta-carbolines as a versatile scaffold for the development of potent and selective kinase inhibitors with unusual binding modes. J Med Chem. 2012 Jan 12;55(1):403-13. DMI8217 RU https://pubmed.ncbi.nlm.nih.gov/22136433 DMI8217 DI DMI8217 DMI8217 DN PMID22136433C20 DMI8217 MI TTCGOIN DMI8217 MN PIM-3 protein kinase (PIM3) DMI8217 MT DTT DMI8217 MA Inhibitor DMI8217 RN 7,8-dichloro-1-oxo-beta-carbolines as a versatile scaffold for the development of potent and selective kinase inhibitors with unusual binding modes. J Med Chem. 2012 Jan 12;55(1):403-13. DMI8217 RU https://pubmed.ncbi.nlm.nih.gov/22136433 DMI8217 DI DMI8217 DMI8217 DN PMID22136433C20 DMI8217 MI TTSL41O DMI8217 MN Protein kinase N1 (PKN1) DMI8217 MT DTT DMI8217 MA Inhibitor DMI8217 RN 7,8-dichloro-1-oxo-beta-carbolines as a versatile scaffold for the development of potent and selective kinase inhibitors with unusual binding modes. J Med Chem. 2012 Jan 12;55(1):403-13. DMI8217 RU https://pubmed.ncbi.nlm.nih.gov/22136433 DMI8217 DI DMI8217 DMI8217 DN PMID22136433C20 DMI8217 MI TTTN5QW DMI8217 MN Serine/threonine-protein kinase pim-1 (PIM1) DMI8217 MT DTT DMI8217 MA Inhibitor DMI8217 RN 7,8-dichloro-1-oxo-beta-carbolines as a versatile scaffold for the development of potent and selective kinase inhibitors with unusual binding modes. J Med Chem. 2012 Jan 12;55(1):403-13. DMI8217 RU https://pubmed.ncbi.nlm.nih.gov/22136433 DMTGVSU DI DMTGVSU DMTGVSU DN PMID22153340C20 DMTGVSU MI TTXZ0KQ DMTGVSU MN Matrix metalloproteinase-12 (MMP-12) DMTGVSU MT DTT DMTGVSU MA Inhibitor DMTGVSU RN Discovery of potent and selective matrix metalloprotease 12 inhibitors for the potential treatment of chronic obstructive pulmonary disease (COPD). Bioorg Med Chem Lett. 2012 Jan 1;22(1):138-43. DMTGVSU RU https://pubmed.ncbi.nlm.nih.gov/22153340 DM4NRG5 DI DM4NRG5 DM4NRG5 DN PMID22266036C12e DM4NRG5 MI TTVBPDM DM4NRG5 MN Metabotropic glutamate receptor 1 (mGluR1) DM4NRG5 MT DTT DM4NRG5 MA Modulator (allosteric modulator) DM4NRG5 RN Fused tricyclic mGluR1 antagonists for the treatment of neuropathic pain. Bioorg Med Chem Lett. 2012 Feb 15;22(4):1575-8. DM4NRG5 RU https://pubmed.ncbi.nlm.nih.gov/22266036 DMFQHVL DI DMFQHVL DMFQHVL DN PMID22266036C9a DMFQHVL MI TTVBPDM DMFQHVL MN Metabotropic glutamate receptor 1 (mGluR1) DMFQHVL MT DTT DMFQHVL MA Modulator (allosteric modulator) DMFQHVL RN Fused tricyclic mGluR1 antagonists for the treatment of neuropathic pain. Bioorg Med Chem Lett. 2012 Feb 15;22(4):1575-8. DMFQHVL RU https://pubmed.ncbi.nlm.nih.gov/22266036 DMVI6EX DI DMVI6EX DMVI6EX DN PMID2231594C3j DMVI6EX MI TTPADOQ DMVI6EX MN HMG-CoA reductase (HMGCR) DMVI6EX MT DTT DMVI6EX MA Inhibitor DMVI6EX RN Phosphorus-containing inhibitors of HMG-CoA reductase. 1. 4-[(2-arylethyl)hydroxyphosphinyl]-3-hydroxy-butanoic acids: a new class of cell-selective inhibitors of cholesterol biosynthesis. J Med Chem. 1990 Nov;33(11):2952-6. DMVI6EX RU https://pubmed.ncbi.nlm.nih.gov/2231594 DMJYHIM DI DMJYHIM DMJYHIM DN PMID2231594C3k DMJYHIM MI TTPADOQ DMJYHIM MN HMG-CoA reductase (HMGCR) DMJYHIM MT DTT DMJYHIM MA Inhibitor DMJYHIM RN Phosphorus-containing inhibitors of HMG-CoA reductase. 1. 4-[(2-arylethyl)hydroxyphosphinyl]-3-hydroxy-butanoic acids: a new class of cell-selective inhibitors of cholesterol biosynthesis. J Med Chem. 1990 Nov;33(11):2952-6. DMJYHIM RU https://pubmed.ncbi.nlm.nih.gov/2231594 DMJQ5B0 DI DMJQ5B0 DMJQ5B0 DN PMID2231594C3q DMJQ5B0 MI TTPADOQ DMJQ5B0 MN HMG-CoA reductase (HMGCR) DMJQ5B0 MT DTT DMJQ5B0 MA Inhibitor DMJQ5B0 RN Phosphorus-containing inhibitors of HMG-CoA reductase. 1. 4-[(2-arylethyl)hydroxyphosphinyl]-3-hydroxy-butanoic acids: a new class of cell-selective inhibitors of cholesterol biosynthesis. J Med Chem. 1990 Nov;33(11):2952-6. DMJQ5B0 RU https://pubmed.ncbi.nlm.nih.gov/2231594 DMJ504Y DI DMJ504Y DMJ504Y DN PMID2231594C3u DMJ504Y MI TTPADOQ DMJ504Y MN HMG-CoA reductase (HMGCR) DMJ504Y MT DTT DMJ504Y MA Inhibitor DMJ504Y RN Phosphorus-containing inhibitors of HMG-CoA reductase. 1. 4-[(2-arylethyl)hydroxyphosphinyl]-3-hydroxy-butanoic acids: a new class of cell-selective inhibitors of cholesterol biosynthesis. J Med Chem. 1990 Nov;33(11):2952-6. DMJ504Y RU https://pubmed.ncbi.nlm.nih.gov/2231594 DMRLG7Z DI DMRLG7Z DMRLG7Z DN PMID22364337C48 DMRLG7Z MI TTXJ47W DMRLG7Z MN Metabotropic glutamate receptor 2 (mGluR2) DMRLG7Z MT DTT DMRLG7Z MA Modulator (allosteric modulator) DMRLG7Z RN Discovery of 1,4-disubstituted 3-cyano-2-pyridones: a new class of positive allosteric modulators of the metabotropic glutamate 2 receptor. J Med Chem. 2012 Mar 8;55(5):2388-405. DMRLG7Z RU https://pubmed.ncbi.nlm.nih.gov/22364337 DM123TU DI DM123TU DM123TU DN PMID22420767C42 DM123TU MI TTWNV8U DM123TU MN Nicotinic acid receptor (HCAR2) DM123TU MT DTT DM123TU MA Modulator (allosteric modulator) DM123TU RN Novel 3,6,7-substituted pyrazolopyrimidines as positive allosteric modulators for the hydroxycarboxylic acid receptor 2 (GPR109A). J Med Chem. 2012 Apr 12;55(7):3563-7. DM123TU RU https://pubmed.ncbi.nlm.nih.gov/22420767 DMCDOHA DI DMCDOHA DMCDOHA DN PMID22464687C15a DMCDOHA MI TTFQEO5 DMCDOHA MN Squalene synthetase (FDFT1) DMCDOHA MT DTT DMCDOHA MA Inhibitor DMCDOHA RN Discovery of novel tricyclic compounds as squalene synthase inhibitors. Bioorg Med Chem. 2012 May 1;20(9):3072-93. DMCDOHA RU https://pubmed.ncbi.nlm.nih.gov/22464687 DMV4ZWD DI DMV4ZWD DMV4ZWD DN PMID22465637C1 DMV4ZWD MI TTICZ1O DMV4ZWD MN Metabotropic glutamate receptor 4 (mGluR4) DMV4ZWD MT DTT DMV4ZWD MA Modulator (allosteric modulator) DMV4ZWD RN 4-(1-Phenyl-1H-pyrazol-4-yl)quinolines as novel, selective and brain penetrant metabotropic glutamate receptor 4 positive allosteric modulators. Bioorg Med Chem Lett. 2012 May 1;22(9):3235-9. DMV4ZWD RU https://pubmed.ncbi.nlm.nih.gov/22465637 DMQXRCW DI DMQXRCW DMQXRCW DN PMID22490048C(R)-10h DMQXRCW MI TTX4RTB DMQXRCW MN Melanin-concentrating hormone receptor 1 (MCHR1) DMQXRCW MT DTT DMQXRCW MA Antagonist DMQXRCW RN Synthesis, structure-activity relationship, and pharmacological studies of novel melanin-concentrating hormone receptor 1 antagonists 3-aminomethylquinolines: reducing human ether-a-go-go-related gene (hERG) associated liabilities. J Med Chem. 2012 May 10;55(9):4336-51. DMQXRCW RU https://pubmed.ncbi.nlm.nih.gov/22490048 DMYQDXO DI DMYQDXO DMYQDXO DN PMID22521646C12 DMYQDXO MI TTQBR95 DMYQDXO MN Stress-activated protein kinase 2a (p38 alpha) DMYQDXO MT DTT DMYQDXO MA Inhibitor DMYQDXO RN Novel triazolopyridylbenzamides as potent and selective p38alpha inhibitors. Bioorg Med Chem Lett. 2012 May 15;22(10):3431-6. DMYQDXO RU https://pubmed.ncbi.nlm.nih.gov/22521646 DMYEMWB DI DMYEMWB DMYEMWB DN PMID22533316C1 DMYEMWB MI TT7O8ZA DMYEMWB MN Lanosterol synthase (LSS) DMYEMWB MT DTT DMYEMWB MA Inhibitor DMYEMWB RN Cytotoxic effects of combination of oxidosqualene cyclase inhibitors with atorvastatin in human cancer cells. J Med Chem. 2012 Jun 14;55(11):4990-5002. DMYEMWB RU https://pubmed.ncbi.nlm.nih.gov/22533316 DMOZG0A DI DMOZG0A DMOZG0A DN PMID22533316C3 DMOZG0A MI TT7O8ZA DMOZG0A MN Lanosterol synthase (LSS) DMOZG0A MT DTT DMOZG0A MA Inhibitor DMOZG0A RN Cytotoxic effects of combination of oxidosqualene cyclase inhibitors with atorvastatin in human cancer cells. J Med Chem. 2012 Jun 14;55(11):4990-5002. DMOZG0A RU https://pubmed.ncbi.nlm.nih.gov/22533316 DMW3UHO DI DMW3UHO DMW3UHO DN PMID22533316C4 DMW3UHO MI TT7O8ZA DMW3UHO MN Lanosterol synthase (LSS) DMW3UHO MT DTT DMW3UHO MA Inhibitor DMW3UHO RN Cytotoxic effects of combination of oxidosqualene cyclase inhibitors with atorvastatin in human cancer cells. J Med Chem. 2012 Jun 14;55(11):4990-5002. DMW3UHO RU https://pubmed.ncbi.nlm.nih.gov/22533316 DMVZQ6U DI DMVZQ6U DMVZQ6U DN PMID22545772C42 DMVZQ6U MI TT7QNVC DMVZQ6U MN Glucose-dependent insulinotropic receptor (GPR119) DMVZQ6U MT DTT DMVZQ6U MA Agonist DMVZQ6U RN Use of small-molecule crystal structures to address solubility in a novel series of G protein coupled receptor 119 agonists: optimization of a lead and in vivo evaluation. J Med Chem. 2012 Jun 14;55(11):5361-79. DMVZQ6U RU https://pubmed.ncbi.nlm.nih.gov/22545772 DMBMYKQ DI DMBMYKQ DMBMYKQ DN PMID22564207C25b DMBMYKQ MI TTPMQSO DMBMYKQ MN ALK tyrosine kinase receptor (ALK) DMBMYKQ MT DTT DMBMYKQ MA Inhibitor DMBMYKQ RN Discovery of an orally efficacious inhibitor of anaplastic lymphoma kinase. J Med Chem. 2012 May 24;55(10):4580-93. DMBMYKQ RU https://pubmed.ncbi.nlm.nih.gov/22564207 DMBMYKQ DI DMBMYKQ DMBMYKQ DN PMID22564207C25b DMBMYKQ MI TT65FL0 DMBMYKQ MN Omphalocele kinase 1 (NUAK1) DMBMYKQ MT DTT DMBMYKQ MA Inhibitor DMBMYKQ RN Discovery of an orally efficacious inhibitor of anaplastic lymphoma kinase. J Med Chem. 2012 May 24;55(10):4580-93. DMBMYKQ RU https://pubmed.ncbi.nlm.nih.gov/22564207 DMBMYKQ DI DMBMYKQ DMBMYKQ DN PMID22564207C25b DMBMYKQ MI TTRA9G0 DMBMYKQ MN Proto-oncogene c-Fer (FER) DMBMYKQ MT DTT DMBMYKQ MA Inhibitor DMBMYKQ RN Discovery of an orally efficacious inhibitor of anaplastic lymphoma kinase. J Med Chem. 2012 May 24;55(10):4580-93. DMBMYKQ RU https://pubmed.ncbi.nlm.nih.gov/22564207 DMBMYKQ DI DMBMYKQ DMBMYKQ DN PMID22564207C25b DMBMYKQ MI TTLBY21 DMBMYKQ MN Proto-oncogene c-Fes (FES) DMBMYKQ MT DTT DMBMYKQ MA Inhibitor DMBMYKQ RN Discovery of an orally efficacious inhibitor of anaplastic lymphoma kinase. J Med Chem. 2012 May 24;55(10):4580-93. DMBMYKQ RU https://pubmed.ncbi.nlm.nih.gov/22564207 DMBMYKQ DI DMBMYKQ DMBMYKQ DN PMID22564207C25b DMBMYKQ MI TT0ZW9O DMBMYKQ MN Ribosomal protein S6 kinase alpha-2 (RSK2) DMBMYKQ MT DTT DMBMYKQ MA Inhibitor DMBMYKQ RN Discovery of an orally efficacious inhibitor of anaplastic lymphoma kinase. J Med Chem. 2012 May 24;55(10):4580-93. DMBMYKQ RU https://pubmed.ncbi.nlm.nih.gov/22564207 DMBMYKQ DI DMBMYKQ DMBMYKQ DN PMID22564207C25b DMBMYKQ MI TTUM2ZR DMBMYKQ MN Ribosomal protein S6 kinase alpha-3 (RSK3) DMBMYKQ MT DTT DMBMYKQ MA Inhibitor DMBMYKQ RN Discovery of an orally efficacious inhibitor of anaplastic lymphoma kinase. J Med Chem. 2012 May 24;55(10):4580-93. DMBMYKQ RU https://pubmed.ncbi.nlm.nih.gov/22564207 DMBMYKQ DI DMBMYKQ DMBMYKQ DN PMID22564207C25b DMBMYKQ MI TT3KYWB DMBMYKQ MN Ribosomal protein S6 kinase alpha-6 (RSK6) DMBMYKQ MT DTT DMBMYKQ MA Inhibitor DMBMYKQ RN Discovery of an orally efficacious inhibitor of anaplastic lymphoma kinase. J Med Chem. 2012 May 24;55(10):4580-93. DMBMYKQ RU https://pubmed.ncbi.nlm.nih.gov/22564207 DMBMYKQ DI DMBMYKQ DMBMYKQ DN PMID22564207C25b DMBMYKQ MI TT9ABMF DMBMYKQ MN Serine/threonine-protein kinase Chk2 (RAD53) DMBMYKQ MT DTT DMBMYKQ MA Inhibitor DMBMYKQ RN Discovery of an orally efficacious inhibitor of anaplastic lymphoma kinase. J Med Chem. 2012 May 24;55(10):4580-93. DMBMYKQ RU https://pubmed.ncbi.nlm.nih.gov/22564207 DM9SLUK DI DM9SLUK DM9SLUK DN PMID22595175C4g DM9SLUK MI TTQAJF1 DM9SLUK MN Cathepsin G (CTSG) DM9SLUK MT DTT DM9SLUK MA Inhibitor DM9SLUK RN N-Acyl and N-sulfonyloxazolidine-2,4-diones are pseudo-irreversible inhibitors of serine proteases. Bioorg Med Chem Lett. 2012 Jun 15;22(12):3993-7. DM9SLUK RU https://pubmed.ncbi.nlm.nih.gov/22595175 DM9SLUK DI DM9SLUK DM9SLUK DN PMID22595175C4g DM9SLUK MI TT5MLC4 DM9SLUK MN Leukocyte proteinase-3 (PRTN3) DM9SLUK MT DTT DM9SLUK MA Inhibitor DM9SLUK RN N-Acyl and N-sulfonyloxazolidine-2,4-diones are pseudo-irreversible inhibitors of serine proteases. Bioorg Med Chem Lett. 2012 Jun 15;22(12):3993-7. DM9SLUK RU https://pubmed.ncbi.nlm.nih.gov/22595175 DM9SLUK DI DM9SLUK DM9SLUK DN PMID22595175C4g DM9SLUK MI TTPLTSQ DM9SLUK MN Neutrophil elastase (NE) DM9SLUK MT DTT DM9SLUK MA Inhibitor DM9SLUK RN N-Acyl and N-sulfonyloxazolidine-2,4-diones are pseudo-irreversible inhibitors of serine proteases. Bioorg Med Chem Lett. 2012 Jun 15;22(12):3993-7. DM9SLUK RU https://pubmed.ncbi.nlm.nih.gov/22595175 DM7OJ5Q DI DM7OJ5Q DM7OJ5Q DN PMID22607879CR-(-)-5f DM7OJ5Q MI TTOJ1NF DM7OJ5Q MN FMLP-related receptor I (FPR2) DM7OJ5Q MT DTT DM7OJ5Q MA Agonist DM7OJ5Q RN Synthesis, enantioresolution, and activity profile of chiral 6-methyl-2,4-disubstituted pyridazin-3(2H)-ones as potent N-formyl peptide receptor agonists. Bioorg Med Chem. 2012 Jun 15;20(12):3781-92. DM7OJ5Q RU https://pubmed.ncbi.nlm.nih.gov/22607879 DM7OJ5Q DI DM7OJ5Q DM7OJ5Q DN PMID22607879CR-(-)-5f DM7OJ5Q MI TT5Y4EM DM7OJ5Q MN N-formyl peptide receptor (FPR1) DM7OJ5Q MT DTT DM7OJ5Q MA Agonist DM7OJ5Q RN Synthesis, enantioresolution, and activity profile of chiral 6-methyl-2,4-disubstituted pyridazin-3(2H)-ones as potent N-formyl peptide receptor agonists. Bioorg Med Chem. 2012 Jun 15;20(12):3781-92. DM7OJ5Q RU https://pubmed.ncbi.nlm.nih.gov/22607879 DM19D7G DI DM19D7G DM19D7G DN PMID22686657C(R)-26 DM19D7G MI TTJOKD1 DM19D7G MN Cathepsin F (CTSF) DM19D7G MT DTT DM19D7G MA Inhibitor DM19D7G RN Selective nitrile inhibitors to modulate the proteolytic synergism of cathepsins S and F. J Med Chem. 2012 Jun 28;55(12):5982-6. DM19D7G RU https://pubmed.ncbi.nlm.nih.gov/22686657 DM19D7G DI DM19D7G DM19D7G DN PMID22686657C(R)-26 DM19D7G MI TTUMQVO DM19D7G MN Cathepsin S (CTSS) DM19D7G MT DTT DM19D7G MA Inhibitor DM19D7G RN Selective nitrile inhibitors to modulate the proteolytic synergism of cathepsins S and F. J Med Chem. 2012 Jun 28;55(12):5982-6. DM19D7G RU https://pubmed.ncbi.nlm.nih.gov/22686657 DMH5RFU DI DMH5RFU DMH5RFU DN PMID22765894C8h DMH5RFU MI TTRLW2X DMH5RFU MN Fibroblast growth factor receptor 1 (FGFR1) DMH5RFU MT DTT DMH5RFU MA Inhibitor DMH5RFU RN The design, synthesis, and biological evaluation of potent receptor tyrosine kinase inhibitors. Bioorg Med Chem Lett. 2012 Aug 1;22(15):4979-85. DMH5RFU RU https://pubmed.ncbi.nlm.nih.gov/22765894 DMH5RFU DI DMH5RFU DMH5RFU DN PMID22765894C8h DMH5RFU MI TTGJCWZ DMH5RFU MN Fms-like tyrosine kinase 3 (FLT-3) DMH5RFU MT DTT DMH5RFU MA Inhibitor DMH5RFU RN The design, synthesis, and biological evaluation of potent receptor tyrosine kinase inhibitors. Bioorg Med Chem Lett. 2012 Aug 1;22(15):4979-85. DMH5RFU RU https://pubmed.ncbi.nlm.nih.gov/22765894 DMH5RFU DI DMH5RFU DMH5RFU DN PMID22765894C8h DMH5RFU MI TTI0AHJ DMH5RFU MN MEK kinase kinase 3 (MAP4K3) DMH5RFU MT DTT DMH5RFU MA Inhibitor DMH5RFU RN The design, synthesis, and biological evaluation of potent receptor tyrosine kinase inhibitors. Bioorg Med Chem Lett. 2012 Aug 1;22(15):4979-85. DMH5RFU RU https://pubmed.ncbi.nlm.nih.gov/22765894 DMH5RFU DI DMH5RFU DMH5RFU DN PMID22765894C8h DMH5RFU MI TT8FYO9 DMH5RFU MN Platelet-derived growth factor receptor alpha (PDGFRA) DMH5RFU MT DTT DMH5RFU MA Inhibitor DMH5RFU RN The design, synthesis, and biological evaluation of potent receptor tyrosine kinase inhibitors. Bioorg Med Chem Lett. 2012 Aug 1;22(15):4979-85. DMH5RFU RU https://pubmed.ncbi.nlm.nih.gov/22765894 DMH5RFU DI DMH5RFU DMH5RFU DN PMID22765894C8h DMH5RFU MI TTI7421 DMH5RFU MN Platelet-derived growth factor receptor beta (PDGFRB) DMH5RFU MT DTT DMH5RFU MA Inhibitor DMH5RFU RN The design, synthesis, and biological evaluation of potent receptor tyrosine kinase inhibitors. Bioorg Med Chem Lett. 2012 Aug 1;22(15):4979-85. DMH5RFU RU https://pubmed.ncbi.nlm.nih.gov/22765894 DMH5RFU DI DMH5RFU DMH5RFU DN PMID22765894C8h DMH5RFU MI TT6PKBN DMH5RFU MN Proto-oncogene c-Src (SRC) DMH5RFU MT DTT DMH5RFU MA Inhibitor DMH5RFU RN The design, synthesis, and biological evaluation of potent receptor tyrosine kinase inhibitors. Bioorg Med Chem Lett. 2012 Aug 1;22(15):4979-85. DMH5RFU RU https://pubmed.ncbi.nlm.nih.gov/22765894 DMH5RFU DI DMH5RFU DMH5RFU DN PMID22765894C8h DMH5RFU MI TTUM2ZR DMH5RFU MN Ribosomal protein S6 kinase alpha-3 (RSK3) DMH5RFU MT DTT DMH5RFU MA Inhibitor DMH5RFU RN The design, synthesis, and biological evaluation of potent receptor tyrosine kinase inhibitors. Bioorg Med Chem Lett. 2012 Aug 1;22(15):4979-85. DMH5RFU RU https://pubmed.ncbi.nlm.nih.gov/22765894 DMH5RFU DI DMH5RFU DMH5RFU DN PMID22765894C8h DMH5RFU MI TTX41N9 DMH5RFU MN Tyrosine-protein kinase Kit (KIT) DMH5RFU MT DTT DMH5RFU MA Inhibitor DMH5RFU RN The design, synthesis, and biological evaluation of potent receptor tyrosine kinase inhibitors. Bioorg Med Chem Lett. 2012 Aug 1;22(15):4979-85. DMH5RFU RU https://pubmed.ncbi.nlm.nih.gov/22765894 DMH5RFU DI DMH5RFU DMH5RFU DN PMID22765894C8h DMH5RFU MI TTUTJGQ DMH5RFU MN Vascular endothelial growth factor receptor 2 (KDR) DMH5RFU MT DTT DMH5RFU MA Inhibitor DMH5RFU RN The design, synthesis, and biological evaluation of potent receptor tyrosine kinase inhibitors. Bioorg Med Chem Lett. 2012 Aug 1;22(15):4979-85. DMH5RFU RU https://pubmed.ncbi.nlm.nih.gov/22765894 DMH5RFU DI DMH5RFU DMH5RFU DN PMID22765894C8h DMH5RFU MI TTDCBX5 DMH5RFU MN Vascular endothelial growth factor receptor 3 (FLT-4) DMH5RFU MT DTT DMH5RFU MA Inhibitor DMH5RFU RN The design, synthesis, and biological evaluation of potent receptor tyrosine kinase inhibitors. Bioorg Med Chem Lett. 2012 Aug 1;22(15):4979-85. DMH5RFU RU https://pubmed.ncbi.nlm.nih.gov/22765894 DMH5RFU DI DMH5RFU DMH5RFU DN PMID22765894C8h DMH5RFU MI TT1VAUK DMH5RFU MN VEGFR1 messenger RNA (VEGFR1 mRNA) DMH5RFU MT DTT DMH5RFU MA Inhibitor DMH5RFU RN The design, synthesis, and biological evaluation of potent receptor tyrosine kinase inhibitors. Bioorg Med Chem Lett. 2012 Aug 1;22(15):4979-85. DMH5RFU RU https://pubmed.ncbi.nlm.nih.gov/22765894 DM0XQZO DI DM0XQZO DM0XQZO DN PMID22795084C1 DM0XQZO MI TTL4XSQ DM0XQZO MN Protein arginine methyltransferase 3 (PRMT3) DM0XQZO MT DTT DM0XQZO MA Inhibitor DM0XQZO RN An allosteric inhibitor of protein arginine methyltransferase 3. Structure. 2012 Aug 8;20(8):1425-35. DM0XQZO RU https://pubmed.ncbi.nlm.nih.gov/22795084 DMVK1GT DI DMVK1GT DMVK1GT DN PMID22802221C21 DMVK1GT MI TTQVOEI DMVK1GT MN Angiotensin II receptor type-2 (AGTR2) DMVK1GT MT DTT DMVK1GT MA Agonist DMVK1GT RN Compound 21 induces vasorelaxation via an endothelium- and angiotensin II type 2 receptor-independent mechanism. Hypertension. 2012 Sep;60(3):722-9. DMVK1GT RU https://pubmed.ncbi.nlm.nih.gov/22802221 DM6RY4F DI DM6RY4F DM6RY4F DN PMID22861813C8a DM6RY4F MI TT5NILS DM6RY4F MN Cathepsin A (CTSA) DM6RY4F MT DTT DM6RY4F MA Inhibitor DM6RY4F RN Novel beta-amino acid derivatives as inhibitors of cathepsin A. J Med Chem. 2012 Sep 13;55(17):7636-49. DM6RY4F RU https://pubmed.ncbi.nlm.nih.gov/22861813 DMLUCSB DI DMLUCSB DMLUCSB DN PMID22873688C3a DMLUCSB MI TTA93TL DMLUCSB MN P2Y purinoceptor 1 (P2RY1) DMLUCSB MT DTT DMLUCSB MA Agonist DMLUCSB RN Identification of a promising drug candidate for the treatment of type 2 diabetes based on a P2Y(1) receptor agonist. J Med Chem. 2012 Sep 13;55(17):7623-35. DMLUCSB RU https://pubmed.ncbi.nlm.nih.gov/22873688 DMXDTPL DI DMXDTPL DMXDTPL DN PMID22902653C30 DMXDTPL MI TTWL9TY DMXDTPL MN LIM domain kinase-1 (LIMK-1) DMXDTPL MT DTT DMXDTPL MA Inhibitor DMXDTPL RN Modulation of cofilin phosphorylation by inhibition of the Lim family kinases. Bioorg Med Chem Lett. 2012 Sep 15;22(18):5995-8. DMXDTPL RU https://pubmed.ncbi.nlm.nih.gov/22902653 DMXDTPL DI DMXDTPL DMXDTPL DN PMID22902653C30 DMXDTPL MI TTASMD8 DMXDTPL MN LIM domain kinase-2 (LIMK-2) DMXDTPL MT DTT DMXDTPL MA Inhibitor DMXDTPL RN Modulation of cofilin phosphorylation by inhibition of the Lim family kinases. Bioorg Med Chem Lett. 2012 Sep 15;22(18):5995-8. DMXDTPL RU https://pubmed.ncbi.nlm.nih.gov/22902653 DMXDTPL DI DMXDTPL DMXDTPL DN PMID22902653C30 DMXDTPL MI TTWKT3Y DMXDTPL MN Testis-specific kinase 1 (TESK1) DMXDTPL MT DTT DMXDTPL MA Inhibitor DMXDTPL RN Modulation of cofilin phosphorylation by inhibition of the Lim family kinases. Bioorg Med Chem Lett. 2012 Sep 15;22(18):5995-8. DMXDTPL RU https://pubmed.ncbi.nlm.nih.gov/22902653 DMXDTPL DI DMXDTPL DMXDTPL DN PMID22902653C30 DMXDTPL MI TTRMD8U DMXDTPL MN Testis-specific kinase 2 (TESK2) DMXDTPL MT DTT DMXDTPL MA Inhibitor DMXDTPL RN Modulation of cofilin phosphorylation by inhibition of the Lim family kinases. Bioorg Med Chem Lett. 2012 Sep 15;22(18):5995-8. DMXDTPL RU https://pubmed.ncbi.nlm.nih.gov/22902653 DMWVTAE DI DMWVTAE DMWVTAE DN PMID22902653C31 DMWVTAE MI TTWL9TY DMWVTAE MN LIM domain kinase-1 (LIMK-1) DMWVTAE MT DTT DMWVTAE MA Inhibitor DMWVTAE RN Modulation of cofilin phosphorylation by inhibition of the Lim family kinases. Bioorg Med Chem Lett. 2012 Sep 15;22(18):5995-8. DMWVTAE RU https://pubmed.ncbi.nlm.nih.gov/22902653 DMWVTAE DI DMWVTAE DMWVTAE DN PMID22902653C31 DMWVTAE MI TTASMD8 DMWVTAE MN LIM domain kinase-2 (LIMK-2) DMWVTAE MT DTT DMWVTAE MA Inhibitor DMWVTAE RN Modulation of cofilin phosphorylation by inhibition of the Lim family kinases. Bioorg Med Chem Lett. 2012 Sep 15;22(18):5995-8. DMWVTAE RU https://pubmed.ncbi.nlm.nih.gov/22902653 DMWVTAE DI DMWVTAE DMWVTAE DN PMID22902653C31 DMWVTAE MI TTWKT3Y DMWVTAE MN Testis-specific kinase 1 (TESK1) DMWVTAE MT DTT DMWVTAE MA Inhibitor DMWVTAE RN Modulation of cofilin phosphorylation by inhibition of the Lim family kinases. Bioorg Med Chem Lett. 2012 Sep 15;22(18):5995-8. DMWVTAE RU https://pubmed.ncbi.nlm.nih.gov/22902653 DMWVTAE DI DMWVTAE DMWVTAE DN PMID22902653C31 DMWVTAE MI TTRMD8U DMWVTAE MN Testis-specific kinase 2 (TESK2) DMWVTAE MT DTT DMWVTAE MA Inhibitor DMWVTAE RN Modulation of cofilin phosphorylation by inhibition of the Lim family kinases. Bioorg Med Chem Lett. 2012 Sep 15;22(18):5995-8. DMWVTAE RU https://pubmed.ncbi.nlm.nih.gov/22902653 DMLVKPG DI DMLVKPG DMLVKPG DN PMID22902653C35 DMLVKPG MI TTWL9TY DMLVKPG MN LIM domain kinase-1 (LIMK-1) DMLVKPG MT DTT DMLVKPG MA Inhibitor DMLVKPG RN Modulation of cofilin phosphorylation by inhibition of the Lim family kinases. Bioorg Med Chem Lett. 2012 Sep 15;22(18):5995-8. DMLVKPG RU https://pubmed.ncbi.nlm.nih.gov/22902653 DMLVKPG DI DMLVKPG DMLVKPG DN PMID22902653C35 DMLVKPG MI TTASMD8 DMLVKPG MN LIM domain kinase-2 (LIMK-2) DMLVKPG MT DTT DMLVKPG MA Inhibitor DMLVKPG RN Modulation of cofilin phosphorylation by inhibition of the Lim family kinases. Bioorg Med Chem Lett. 2012 Sep 15;22(18):5995-8. DMLVKPG RU https://pubmed.ncbi.nlm.nih.gov/22902653 DMLVKPG DI DMLVKPG DMLVKPG DN PMID22902653C35 DMLVKPG MI TTWKT3Y DMLVKPG MN Testis-specific kinase 1 (TESK1) DMLVKPG MT DTT DMLVKPG MA Inhibitor DMLVKPG RN Modulation of cofilin phosphorylation by inhibition of the Lim family kinases. Bioorg Med Chem Lett. 2012 Sep 15;22(18):5995-8. DMLVKPG RU https://pubmed.ncbi.nlm.nih.gov/22902653 DMLVKPG DI DMLVKPG DMLVKPG DN PMID22902653C35 DMLVKPG MI TTRMD8U DMLVKPG MN Testis-specific kinase 2 (TESK2) DMLVKPG MT DTT DMLVKPG MA Inhibitor DMLVKPG RN Modulation of cofilin phosphorylation by inhibition of the Lim family kinases. Bioorg Med Chem Lett. 2012 Sep 15;22(18):5995-8. DMLVKPG RU https://pubmed.ncbi.nlm.nih.gov/22902653 DMOKZ3R DI DMOKZ3R DMOKZ3R DN PMID2296027C25 DMOKZ3R MI TTPADOQ DMOKZ3R MN HMG-CoA reductase (HMGCR) DMOKZ3R MT DTT DMOKZ3R MA Inhibitor DMOKZ3R RN Inhibitors of cholesterol biosynthesis. 2. 1,3,5-trisubstituted [2-(tetrahydro-4-hydroxy-2-oxopyran-6-yl)ethyl]pyrazoles. J Med Chem. 1990 Jan;33(1):31-8. DMOKZ3R RU https://pubmed.ncbi.nlm.nih.gov/2296027 DMY267E DI DMY267E DMY267E DN PMID2296027C29 DMY267E MI TTPADOQ DMY267E MN HMG-CoA reductase (HMGCR) DMY267E MT DTT DMY267E MA Inhibitor DMY267E RN Inhibitors of cholesterol biosynthesis. 2. 1,3,5-trisubstituted [2-(tetrahydro-4-hydroxy-2-oxopyran-6-yl)ethyl]pyrazoles. J Med Chem. 1990 Jan;33(1):31-8. DMY267E RU https://pubmed.ncbi.nlm.nih.gov/2296027 DM6VG8K DI DM6VG8K DM6VG8K DN PMID2296036C2g DM6VG8K MI TTPADOQ DM6VG8K MN HMG-CoA reductase (HMGCR) DM6VG8K MT DTT DM6VG8K MA Inhibitor DM6VG8K RN Synthesis and biological activity of new HMG-CoA reductase inhibitors. 1. Lactones of pyridine- and pyrimidine-substituted 3,5-dihydroxy-6-heptenoic (-heptanoic) acids. J Med Chem. 1990 Jan;33(1):52-60. DM6VG8K RU https://pubmed.ncbi.nlm.nih.gov/2296036 DMBXCNA DI DMBXCNA DMBXCNA DN PMID2296036C2t DMBXCNA MI TTPADOQ DMBXCNA MN HMG-CoA reductase (HMGCR) DMBXCNA MT DTT DMBXCNA MA Inhibitor DMBXCNA RN Synthesis and biological activity of new HMG-CoA reductase inhibitors. 1. Lactones of pyridine- and pyrimidine-substituted 3,5-dihydroxy-6-heptenoic (-heptanoic) acids. J Med Chem. 1990 Jan;33(1):52-60. DMBXCNA RU https://pubmed.ncbi.nlm.nih.gov/2296036 DMC6HQL DI DMC6HQL DMC6HQL DN PMID2296036C4d DMC6HQL MI TTPADOQ DMC6HQL MN HMG-CoA reductase (HMGCR) DMC6HQL MT DTT DMC6HQL MA Inhibitor DMC6HQL RN Synthesis and biological activity of new HMG-CoA reductase inhibitors. 1. Lactones of pyridine- and pyrimidine-substituted 3,5-dihydroxy-6-heptenoic (-heptanoic) acids. J Med Chem. 1990 Jan;33(1):52-60. DMC6HQL RU https://pubmed.ncbi.nlm.nih.gov/2296036 DMSJ94N DI DMSJ94N DMSJ94N DN PMID2296036C4i DMSJ94N MI TTPADOQ DMSJ94N MN HMG-CoA reductase (HMGCR) DMSJ94N MT DTT DMSJ94N MA Inhibitor DMSJ94N RN Synthesis and biological activity of new HMG-CoA reductase inhibitors. 1. Lactones of pyridine- and pyrimidine-substituted 3,5-dihydroxy-6-heptenoic (-heptanoic) acids. J Med Chem. 1990 Jan;33(1):52-60. DMSJ94N RU https://pubmed.ncbi.nlm.nih.gov/2296036 DMAW86U DI DMAW86U DMAW86U DN PMID22984835C20o DMAW86U MI TTZ1DT0 DMAW86U MN P2Y purinoceptor 12 (P2RY12) DMAW86U MT DTT DMAW86U MA Antagonist DMAW86U RN Identification of high-affinity P2Y antagonists based on a phenylpyrazole glutamic acid piperazine backbone. J Med Chem. 2012 Oct 25;55(20):8615-29. DMAW86U RU https://pubmed.ncbi.nlm.nih.gov/22984835 DMMI9JE DI DMMI9JE DMMI9JE DN PMID22984835C4 DMMI9JE MI TTZ1DT0 DMMI9JE MN P2Y purinoceptor 12 (P2RY12) DMMI9JE MT DTT DMMI9JE MA Antagonist DMMI9JE RN Identification of high-affinity P2Y antagonists based on a phenylpyrazole glutamic acid piperazine backbone. J Med Chem. 2012 Oct 25;55(20):8615-29. DMMI9JE RU https://pubmed.ncbi.nlm.nih.gov/22984835 DMW579R DI DMW579R DMW579R DN PMID23083103C4 DMW579R MI TTZ1DT0 DMW579R MN P2Y purinoceptor 12 (P2RY12) DMW579R MT DTT DMW579R MA Antagonist DMW579R RN Modified diadenosine tetraphosphates with dual specificity for P2Y1 and P2Y12 are potent antagonists of ADP-induced platelet activation. J Thromb Haemost. 2012 Dec;10(12):2573-80. DMW579R RU https://pubmed.ncbi.nlm.nih.gov/23083103 DMURP5Y DI DMURP5Y DMURP5Y DN PMID23084894C10i DMURP5Y MI TTVBPDM DMURP5Y MN Metabotropic glutamate receptor 1 (mGluR1) DMURP5Y MT DTT DMURP5Y MA Modulator (allosteric modulator) DMURP5Y RN Synthesis and SAR development of novel mGluR1 antagonists for the treatment of chronic pain. Bioorg Med Chem Lett. 2012 Dec 1;22(23):7223-6. DMURP5Y RU https://pubmed.ncbi.nlm.nih.gov/23084894 DM4ATLM DI DM4ATLM DM4ATLM DN PMID23084894C9n DM4ATLM MI TTVBPDM DM4ATLM MN Metabotropic glutamate receptor 1 (mGluR1) DM4ATLM MT DTT DM4ATLM MA Modulator (allosteric modulator) DM4ATLM RN Synthesis and SAR development of novel mGluR1 antagonists for the treatment of chronic pain. Bioorg Med Chem Lett. 2012 Dec 1;22(23):7223-6. DM4ATLM RU https://pubmed.ncbi.nlm.nih.gov/23084894 DMWS7O9 DI DMWS7O9 DMWS7O9 DN PMID23099093C17d DMWS7O9 MI TTRPDBG DMWS7O9 MN Inhibitor of nuclear factor kappa-B kinase (IKK) DMWS7O9 MT DTT DMWS7O9 MA Inhibitor DMWS7O9 RN Synthesis and structure-activity relationships of a novel series of pyrimidines as potent inhibitors of TBK1/IKKepsilon kinases. Bioorg Med Chem Lett. 2012 Dec 1;22(23):7169-73. DMWS7O9 RU https://pubmed.ncbi.nlm.nih.gov/23099093 DMWS7O9 DI DMWS7O9 DMWS7O9 DN PMID23099093C17d DMWS7O9 MI TT3DCYJ DMWS7O9 MN Microtubule affinity regulating kinase 3 (MARK3) DMWS7O9 MT DTT DMWS7O9 MA Inhibitor DMWS7O9 RN Synthesis and structure-activity relationships of a novel series of pyrimidines as potent inhibitors of TBK1/IKKepsilon kinases. Bioorg Med Chem Lett. 2012 Dec 1;22(23):7169-73. DMWS7O9 RU https://pubmed.ncbi.nlm.nih.gov/23099093 DMWS7O9 DI DMWS7O9 DMWS7O9 DN PMID23099093C17d DMWS7O9 MI TTH5TC2 DMWS7O9 MN NF-kappa-B-activating kinase (TBK1) DMWS7O9 MT DTT DMWS7O9 MA Inhibitor DMWS7O9 RN Synthesis and structure-activity relationships of a novel series of pyrimidines as potent inhibitors of TBK1/IKKepsilon kinases. Bioorg Med Chem Lett. 2012 Dec 1;22(23):7169-73. DMWS7O9 RU https://pubmed.ncbi.nlm.nih.gov/23099093 DMWS7O9 DI DMWS7O9 DMWS7O9 DN PMID23099093C17d DMWS7O9 MI TTJQT60 DMWS7O9 MN TGF-beta-activated kinase 1 (MAP3K7) DMWS7O9 MT DTT DMWS7O9 MA Inhibitor DMWS7O9 RN Synthesis and structure-activity relationships of a novel series of pyrimidines as potent inhibitors of TBK1/IKKepsilon kinases. Bioorg Med Chem Lett. 2012 Dec 1;22(23):7169-73. DMWS7O9 RU https://pubmed.ncbi.nlm.nih.gov/23099093 DM3Z6F4 DI DM3Z6F4 DM3Z6F4 DN PMID23147077C10 DM3Z6F4 MI TTOQCD8 DM3Z6F4 MN Apoptosis signal-regulating kinase 1 (MAP3K5) DM3Z6F4 MT DTT DM3Z6F4 MA Inhibitor DM3Z6F4 RN Design and biological evaluation of imidazo[1,2-a]pyridines as novel and potent ASK1 inhibitors. Bioorg Med Chem Lett. 2012 Dec 15;22(24):7326-9. DM3Z6F4 RU https://pubmed.ncbi.nlm.nih.gov/23147077 DM3Z6F4 DI DM3Z6F4 DM3Z6F4 DN PMID23147077C10 DM3Z6F4 MI TT64GC2 DM3Z6F4 MN Apoptosis signal-regulating kinase 2 (MAP3K6) DM3Z6F4 MT DTT DM3Z6F4 MA Inhibitor DM3Z6F4 RN Design and biological evaluation of imidazo[1,2-a]pyridines as novel and potent ASK1 inhibitors. Bioorg Med Chem Lett. 2012 Dec 15;22(24):7326-9. DM3Z6F4 RU https://pubmed.ncbi.nlm.nih.gov/23147077 DMBT92F DI DMBT92F DMBT92F DN PMID23232060C5 DMBT92F MI TTPB1W3 DMBT92F MN TRAF2 and NCK interacting kinase (TNIK) DMBT92F MT DTT DMBT92F MA Inhibitor DMBT92F RN Discovery of 4-phenyl-2-phenylaminopyridine based TNIK inhibitors. Bioorg Med Chem Lett. 2013 Jan 15;23(2):569-73. DMBT92F RU https://pubmed.ncbi.nlm.nih.gov/23232060 DMOJ8QR DI DMOJ8QR DMOJ8QR DN PMID23312943C21 DMOJ8QR MI TT6NI13 DMOJ8QR MN MEK kinase kinase 4 (MAP4K4) DMOJ8QR MT DTT DMOJ8QR MA Inhibitor DMOJ8QR RN Optimization of highly selective 2,4-diaminopyrimidine-5-carboxamide inhibitors of Sky kinase. Bioorg Med Chem Lett. 2013 Feb 15;23(4):1051-5. DMOJ8QR RU https://pubmed.ncbi.nlm.nih.gov/23312943 DMOJ8QR DI DMOJ8QR DMOJ8QR DN PMID23312943C21 DMOJ8QR MI TTOU65C DMOJ8QR MN Tyrosine-protein kinase SYK (SYK) DMOJ8QR MT DTT DMOJ8QR MA Inhibitor DMOJ8QR RN Optimization of highly selective 2,4-diaminopyrimidine-5-carboxamide inhibitors of Sky kinase. Bioorg Med Chem Lett. 2013 Feb 15;23(4):1051-5. DMOJ8QR RU https://pubmed.ncbi.nlm.nih.gov/23312943 DM4NAC9 DI DM4NAC9 DM4NAC9 DN PMID23357634C24d DM4NAC9 MI TTHS256 DM4NAC9 MN Metabotropic glutamate receptor 5 (mGluR5) DM4NAC9 MT DTT DM4NAC9 MA Modulator (allosteric modulator) DM4NAC9 RN Discovery and structure-activity relationship of 1,3-cyclohexyl amide derivatives as novel mGluR5 negative allosteric modulators. Bioorg Med Chem Lett. 2013 Mar 1;23(5):1398-406. DM4NAC9 RU https://pubmed.ncbi.nlm.nih.gov/23357634 DMPHKJI DI DMPHKJI DMPHKJI DN PMID23368907C16 DMPHKJI MI TTA93TL DMPHKJI MN P2Y purinoceptor 1 (P2RY1) DMPHKJI MT DTT DMPHKJI MA Antagonist DMPHKJI RN Two disparate ligand-binding sites in the human P2Y1 receptor. Nature. 2015 Apr 16;520(7547):317-21. DMPHKJI RU https://pubmed.ncbi.nlm.nih.gov/25822790 DMEZSHI DI DMEZSHI DMEZSHI DN PMID23374866C31 DMEZSHI MI TT4LIAC DMEZSHI MN Serine/threonine-protein kinase NIK (MAP3K14) DMEZSHI MT DTT DMEZSHI MA Inhibitor DMEZSHI RN Inhibiting NF- B-inducing kinase (NIK): discovery, structure-based design, synthesis, structure-activity relationship, and co-crystal structures. Bioorg Med Chem Lett. 2013 Mar 1;23(5):1238-44. DMEZSHI RU https://pubmed.ncbi.nlm.nih.gov/23374866 DMRC14X DI DMRC14X DMRC14X DN PMID23374867C24 DMRC14X MI TTHS256 DMRC14X MN Metabotropic glutamate receptor 5 (mGluR5) DMRC14X MT DTT DMRC14X MA Modulator (allosteric modulator) DMRC14X RN Discovery of (1R,2R)-N-(4-(6-isopropylpyridin-2-yl)-3-(2-methyl-2H-indazol-5-yl)isothiazol-5-yl)-2-methylcyclopropanecarboxamide, a potent and orally efficacious mGlu5 receptor negative allosteric modulator. Bioorg Med Chem Lett. 2013 Mar 1;23(5):1249-52. DMRC14X RU https://pubmed.ncbi.nlm.nih.gov/23374867 DM9O8I7 DI DM9O8I7 DM9O8I7 DN PMID23412139C16 DM9O8I7 MI TT8JRS7 DM9O8I7 MN Beta-secretase (BACE) DM9O8I7 MT DTT DM9O8I7 MA Inhibitor DM9O8I7 RN Discovery of an Orally Available, Brain Penetrant BACE1 Inhibitor that Affords Robust CNS A Reduction. ACS Med Chem Lett. 2012 Nov 8;3(11):897-902. DM9O8I7 RU https://pubmed.ncbi.nlm.nih.gov/23412139 DMNVQ29 DI DMNVQ29 DMNVQ29 DN PMID23414845C30 DMNVQ29 MI TTON5IT DMNVQ29 MN Focal adhesion kinase 1 (FAK) DMNVQ29 MT DTT DMNVQ29 MA Inhibitor DMNVQ29 RN Structure-based discovery of cellular-active allosteric inhibitors of FAK. Bioorg Med Chem Lett. 2013 Mar 15;23(6):1779-85. DMNVQ29 RU https://pubmed.ncbi.nlm.nih.gov/23414845 DMZUQ7X DI DMZUQ7X DMZUQ7X DN PMID23428964CI3 DMZUQ7X MI TTPHMWB DMZUQ7X MN Aminopeptidase N (ANPEP) DMZUQ7X MT DTT DMZUQ7X MA Inhibitor DMZUQ7X RN Selective aminopeptidase-N (CD13) inhibitors with relevance to cancer chemotherapy. Bioorg Med Chem. 2013 Apr 1;21(7):2135-44. DMZUQ7X RU https://pubmed.ncbi.nlm.nih.gov/23428964 DMG0XC7 DI DMG0XC7 DMG0XC7 DN PMID23434029C41 DMG0XC7 MI TTHS256 DMG0XC7 MN Metabotropic glutamate receptor 5 (mGluR5) DMG0XC7 MT DTT DMG0XC7 MA Modulator (allosteric modulator) DMG0XC7 RN Discovery of biological evaluation of pyrazole/imidazole amides as mGlu5 receptor negative allosteric modulators. Bioorg Med Chem Lett. 2013 Apr 1;23(7):2134-9. DMG0XC7 RU https://pubmed.ncbi.nlm.nih.gov/23434029 DMG0B4N DI DMG0B4N DMG0B4N DN PMID23434029C53 DMG0B4N MI TTHS256 DMG0B4N MN Metabotropic glutamate receptor 5 (mGluR5) DMG0B4N MT DTT DMG0B4N MA Modulator (allosteric modulator) DMG0B4N RN Discovery of biological evaluation of pyrazole/imidazole amides as mGlu5 receptor negative allosteric modulators. Bioorg Med Chem Lett. 2013 Apr 1;23(7):2134-9. DMG0B4N RU https://pubmed.ncbi.nlm.nih.gov/23434029 DMG4MLA DI DMG4MLA DMG4MLA DN PMID23441572C24 DMG4MLA MI TT6B75U DMG4MLA MN ABL messenger RNA (ABL mRNA) DMG4MLA MT DTT DMG4MLA MA Inhibitor DMG4MLA RN Rapid discovery of a novel series of Abl kinase inhibitors by application of an integrated microfluidic synthesis and screening platform. J Med Chem. 2013 Apr 11;56(7):3033-47. DMG4MLA RU https://pubmed.ncbi.nlm.nih.gov/23441572 DMG4MLA DI DMG4MLA DMG4MLA DN PMID23441572C24 DMG4MLA MI TT1A6HL DMG4MLA MN Tyrosine-protein kinase ABL2 (ABL2) DMG4MLA MT DTT DMG4MLA MA Inhibitor DMG4MLA RN Rapid discovery of a novel series of Abl kinase inhibitors by application of an integrated microfluidic synthesis and screening platform. J Med Chem. 2013 Apr 11;56(7):3033-47. DMG4MLA RU https://pubmed.ncbi.nlm.nih.gov/23441572 DMDYC4J DI DMDYC4J DMDYC4J DN PMID23489211C20 DMDYC4J MI TTLFZVU DMDYC4J MN Ephrin type-A receptor 1 (EPHA1) DMDYC4J MT DTT DMDYC4J MA Inhibitor DMDYC4J RN Amino acid conjugates of lithocholic acid as antagonists of the EphA2 receptor. J Med Chem. 2013 Apr 11;56(7):2936-47. DMDYC4J RU https://pubmed.ncbi.nlm.nih.gov/23489211 DMDYC4J DI DMDYC4J DMDYC4J DN PMID23489211C20 DMDYC4J MI TTRJB2G DMDYC4J MN Ephrin type-A receptor 2 (EPHA2) DMDYC4J MT DTT DMDYC4J MA Inhibitor DMDYC4J RN Amino acid conjugates of lithocholic acid as antagonists of the EphA2 receptor. J Med Chem. 2013 Apr 11;56(7):2936-47. DMDYC4J RU https://pubmed.ncbi.nlm.nih.gov/23489211 DMDYC4J DI DMDYC4J DMDYC4J DN PMID23489211C20 DMDYC4J MI TTHS2LR DMDYC4J MN Ephrin type-A receptor 3 (EPHA3) DMDYC4J MT DTT DMDYC4J MA Inhibitor DMDYC4J RN Amino acid conjugates of lithocholic acid as antagonists of the EphA2 receptor. J Med Chem. 2013 Apr 11;56(7):2936-47. DMDYC4J RU https://pubmed.ncbi.nlm.nih.gov/23489211 DMDYC4J DI DMDYC4J DMDYC4J DN PMID23489211C20 DMDYC4J MI TTG84D3 DMDYC4J MN Ephrin type-A receptor 4 (EPHA4) DMDYC4J MT DTT DMDYC4J MA Inhibitor DMDYC4J RN Amino acid conjugates of lithocholic acid as antagonists of the EphA2 receptor. J Med Chem. 2013 Apr 11;56(7):2936-47. DMDYC4J RU https://pubmed.ncbi.nlm.nih.gov/23489211 DMDYC4J DI DMDYC4J DMDYC4J DN PMID23489211C20 DMDYC4J MI TTV9KOD DMDYC4J MN Ephrin type-A receptor 5 (EPHA5) DMDYC4J MT DTT DMDYC4J MA Inhibitor DMDYC4J RN Amino acid conjugates of lithocholic acid as antagonists of the EphA2 receptor. J Med Chem. 2013 Apr 11;56(7):2936-47. DMDYC4J RU https://pubmed.ncbi.nlm.nih.gov/23489211 DMDYC4J DI DMDYC4J DMDYC4J DN PMID23489211C20 DMDYC4J MI TTFAHWI DMDYC4J MN Ephrin type-A receptor 6 (EPHA6) DMDYC4J MT DTT DMDYC4J MA Inhibitor DMDYC4J RN Amino acid conjugates of lithocholic acid as antagonists of the EphA2 receptor. J Med Chem. 2013 Apr 11;56(7):2936-47. DMDYC4J RU https://pubmed.ncbi.nlm.nih.gov/23489211 DMDYC4J DI DMDYC4J DMDYC4J DN PMID23489211C20 DMDYC4J MI TTAHTVG DMDYC4J MN Ephrin type-A receptor 7 (EPHA7) DMDYC4J MT DTT DMDYC4J MA Inhibitor DMDYC4J RN Amino acid conjugates of lithocholic acid as antagonists of the EphA2 receptor. J Med Chem. 2013 Apr 11;56(7):2936-47. DMDYC4J RU https://pubmed.ncbi.nlm.nih.gov/23489211 DMDYC4J DI DMDYC4J DMDYC4J DN PMID23489211C20 DMDYC4J MI TTHZ2LW DMDYC4J MN Ephrin type-A receptor 8 (EPHA8) DMDYC4J MT DTT DMDYC4J MA Inhibitor DMDYC4J RN Amino acid conjugates of lithocholic acid as antagonists of the EphA2 receptor. J Med Chem. 2013 Apr 11;56(7):2936-47. DMDYC4J RU https://pubmed.ncbi.nlm.nih.gov/23489211 DMDYC4J DI DMDYC4J DMDYC4J DN PMID23489211C20 DMDYC4J MI TT8MDAC DMDYC4J MN Ephrin type-B receptor 1 (EPHB1) DMDYC4J MT DTT DMDYC4J MA Inhibitor DMDYC4J RN Amino acid conjugates of lithocholic acid as antagonists of the EphA2 receptor. J Med Chem. 2013 Apr 11;56(7):2936-47. DMDYC4J RU https://pubmed.ncbi.nlm.nih.gov/23489211 DMDYC4J DI DMDYC4J DMDYC4J DN PMID23489211C20 DMDYC4J MI TTKPV6O DMDYC4J MN Ephrin type-B receptor 2 (EPHB2) DMDYC4J MT DTT DMDYC4J MA Inhibitor DMDYC4J RN Amino acid conjugates of lithocholic acid as antagonists of the EphA2 receptor. J Med Chem. 2013 Apr 11;56(7):2936-47. DMDYC4J RU https://pubmed.ncbi.nlm.nih.gov/23489211 DMDYC4J DI DMDYC4J DMDYC4J DN PMID23489211C20 DMDYC4J MI TT5LM7U DMDYC4J MN Ephrin type-B receptor 3 (EPHB3) DMDYC4J MT DTT DMDYC4J MA Inhibitor DMDYC4J RN Amino acid conjugates of lithocholic acid as antagonists of the EphA2 receptor. J Med Chem. 2013 Apr 11;56(7):2936-47. DMDYC4J RU https://pubmed.ncbi.nlm.nih.gov/23489211 DMDYC4J DI DMDYC4J DMDYC4J DN PMID23489211C20 DMDYC4J MI TTI4ZX2 DMDYC4J MN Ephrin type-B receptor 4 (EPHB4) DMDYC4J MT DTT DMDYC4J MA Inhibitor DMDYC4J RN Amino acid conjugates of lithocholic acid as antagonists of the EphA2 receptor. J Med Chem. 2013 Apr 11;56(7):2936-47. DMDYC4J RU https://pubmed.ncbi.nlm.nih.gov/23489211 DMDYC4J DI DMDYC4J DMDYC4J DN PMID23489211C20 DMDYC4J MI TTZEMUY DMDYC4J MN Ephrin type-B receptor 6 (EPHB6) DMDYC4J MT DTT DMDYC4J MA Inhibitor DMDYC4J RN Amino acid conjugates of lithocholic acid as antagonists of the EphA2 receptor. J Med Chem. 2013 Apr 11;56(7):2936-47. DMDYC4J RU https://pubmed.ncbi.nlm.nih.gov/23489211 DMFQVNL DI DMFQVNL DMFQVNL DN PMID23517011C9 DMFQVNL MI TTRA6BO DMFQVNL MN Bromodomain-containing protein 4 (BRD4) DMFQVNL MT DTT DMFQVNL MA Inhibitor DMFQVNL RN Optimization of 3,5-dimethylisoxazole derivatives as potent bromodomain ligands. J Med Chem. 2013 Apr 25;56(8):3217-27. DMFQVNL RU https://pubmed.ncbi.nlm.nih.gov/23517011 DMPCTED DI DMPCTED DMPCTED DN PMID23521020C7k DMPCTED MI TTI1FPZ DMPCTED MN Epithelial discoidin domain receptor 1 (DDR1) DMPCTED MT DTT DMPCTED MA Inhibitor DMPCTED RN Discovery and optimization of 3-(2-(Pyrazolo[1,5-a]pyrimidin-6-yl)ethynyl)benzamides as novel selective and orally bioavailable discoidin domain receptor 1 (DDR1) inhibitors. J Med Chem. 2013 Apr 25;56(8):3281-95. DMPCTED RU https://pubmed.ncbi.nlm.nih.gov/23521020 DMPCTED DI DMPCTED DMPCTED DN PMID23521020C7k DMPCTED MI TTX41N9 DMPCTED MN Tyrosine-protein kinase Kit (KIT) DMPCTED MT DTT DMPCTED MA Inhibitor DMPCTED RN Discovery and optimization of 3-(2-(Pyrazolo[1,5-a]pyrimidin-6-yl)ethynyl)benzamides as novel selective and orally bioavailable discoidin domain receptor 1 (DDR1) inhibitors. J Med Chem. 2013 Apr 25;56(8):3281-95. DMPCTED RU https://pubmed.ncbi.nlm.nih.gov/23521020 DMB7TE6 DI DMB7TE6 DMB7TE6 DN PMID23589301C1 DMB7TE6 MI TT0FYAN DMB7TE6 MN Free fatty acid receptor 2 (FFAR2) DMB7TE6 MT DTT DMB7TE6 MA Agonist DMB7TE6 RN Defining the molecular basis for the first potent and selective orthosteric agonists of the FFA2 free fatty acid receptor. J Biol Chem. 2013 Jun 14;288(24):17296-312. DMB7TE6 RU https://pubmed.ncbi.nlm.nih.gov/23589301 DMM92IB DI DMM92IB DMM92IB DN PMID23631440C29e DMM92IB MI TTJ4QE7 DMM92IB MN Matrix metalloproteinase-14 (MMP-14) DMM92IB MT DTT DMM92IB MA Inhibitor DMM92IB RN Matrix metalloproteinase inhibitors based on the 3-mercaptopyrrolidine core. J Med Chem. 2013 Jun 13;56(11):4357-73. DMM92IB RU https://pubmed.ncbi.nlm.nih.gov/23631440 DMM92IB DI DMM92IB DMM92IB DN PMID23631440C29e DMM92IB MI TT6X50U DMM92IB MN Matrix metalloproteinase-9 (MMP-9) DMM92IB MT DTT DMM92IB MA Inhibitor DMM92IB RN Matrix metalloproteinase inhibitors based on the 3-mercaptopyrrolidine core. J Med Chem. 2013 Jun 13;56(11):4357-73. DMM92IB RU https://pubmed.ncbi.nlm.nih.gov/23631440 DMA8UQM DI DMA8UQM DMA8UQM DN PMID23634668C14 DMA8UQM MI TT1L79K DMA8UQM MN Methionyl aminopeptidase 1 (METAP1) DMA8UQM MT DTT DMA8UQM MA Inhibitor DMA8UQM RN Pyridinylquinazolines selectively inhibit human methionine aminopeptidase-1 in cells. J Med Chem. 2013 May 23;56(10):3996-4016. DMA8UQM RU https://pubmed.ncbi.nlm.nih.gov/23634668 DMLXOAQ DI DMLXOAQ DMLXOAQ DN PMID23639540C13a DMLXOAQ MI TTJNBQA DMLXOAQ MN Activin receptor-like kinase 2 (ALK-2) DMLXOAQ MT DTT DMLXOAQ MA Inhibitor DMLXOAQ RN Synthesis and structure-activity relationships of a novel and selective bone morphogenetic protein receptor (BMP) inhibitor derived from the pyrazolo[1.5-a]pyrimidine scaffold of dorsomorphin: the discovery of ML347 as an ALK2 versus ALK3 selective MLPCN probe. Bioorg Med Chem Lett. 2013 Jun 1;23(11):3248-52. DMLXOAQ RU https://pubmed.ncbi.nlm.nih.gov/23639540 DMLXOAQ DI DMLXOAQ DMLXOAQ DN PMID23639540C13a DMLXOAQ MI TTGYPTC DMLXOAQ MN Activin receptor-like kinase-1 (ACVRL1) DMLXOAQ MT DTT DMLXOAQ MA Inhibitor DMLXOAQ RN Synthesis and structure-activity relationships of a novel and selective bone morphogenetic protein receptor (BMP) inhibitor derived from the pyrazolo[1.5-a]pyrimidine scaffold of dorsomorphin: the discovery of ML347 as an ALK2 versus ALK3 selective MLPCN probe. Bioorg Med Chem Lett. 2013 Jun 1;23(11):3248-52. DMLXOAQ RU https://pubmed.ncbi.nlm.nih.gov/23639540 DMLXOAQ DI DMLXOAQ DMLXOAQ DN PMID23639540C13a DMLXOAQ MI TTLAFZV DMLXOAQ MN AMP-activated protein kinase (AMPK) DMLXOAQ MT DTT DMLXOAQ MA Inhibitor DMLXOAQ RN Synthesis and structure-activity relationships of a novel and selective bone morphogenetic protein receptor (BMP) inhibitor derived from the pyrazolo[1.5-a]pyrimidine scaffold of dorsomorphin: the discovery of ML347 as an ALK2 versus ALK3 selective MLPCN probe. Bioorg Med Chem Lett. 2013 Jun 1;23(11):3248-52. DMLXOAQ RU https://pubmed.ncbi.nlm.nih.gov/23639540 DMLXOAQ DI DMLXOAQ DMLXOAQ DN PMID23639540C13a DMLXOAQ MI TTGKF90 DMLXOAQ MN Bone morphogenetic protein receptor (BMPR2) DMLXOAQ MT DTT DMLXOAQ MA Inhibitor DMLXOAQ RN Synthesis and structure-activity relationships of a novel and selective bone morphogenetic protein receptor (BMP) inhibitor derived from the pyrazolo[1.5-a]pyrimidine scaffold of dorsomorphin: the discovery of ML347 as an ALK2 versus ALK3 selective MLPCN probe. Bioorg Med Chem Lett. 2013 Jun 1;23(11):3248-52. DMLXOAQ RU https://pubmed.ncbi.nlm.nih.gov/23639540 DMLXOAQ DI DMLXOAQ DMLXOAQ DN PMID23639540C13a DMLXOAQ MI TTZE3P7 DMLXOAQ MN TGF-beta receptor type II (TGFBR2) DMLXOAQ MT DTT DMLXOAQ MA Inhibitor DMLXOAQ RN Synthesis and structure-activity relationships of a novel and selective bone morphogenetic protein receptor (BMP) inhibitor derived from the pyrazolo[1.5-a]pyrimidine scaffold of dorsomorphin: the discovery of ML347 as an ALK2 versus ALK3 selective MLPCN probe. Bioorg Med Chem Lett. 2013 Jun 1;23(11):3248-52. DMLXOAQ RU https://pubmed.ncbi.nlm.nih.gov/23639540 DMLXOAQ DI DMLXOAQ DMLXOAQ DN PMID23639540C13a DMLXOAQ MI TTUTJGQ DMLXOAQ MN Vascular endothelial growth factor receptor 2 (KDR) DMLXOAQ MT DTT DMLXOAQ MA Inhibitor DMLXOAQ RN Synthesis and structure-activity relationships of a novel and selective bone morphogenetic protein receptor (BMP) inhibitor derived from the pyrazolo[1.5-a]pyrimidine scaffold of dorsomorphin: the discovery of ML347 as an ALK2 versus ALK3 selective MLPCN probe. Bioorg Med Chem Lett. 2013 Jun 1;23(11):3248-52. DMLXOAQ RU https://pubmed.ncbi.nlm.nih.gov/23639540 DMSTQGH DI DMSTQGH DMSTQGH DN PMID23639540C13d DMSTQGH MI TTPKHTZ DMSTQGH MN Activin receptor type IB (ACVR1B) DMSTQGH MT DTT DMSTQGH MA Inhibitor DMSTQGH RN Synthesis and structure-activity relationships of a novel and selective bone morphogenetic protein receptor (BMP) inhibitor derived from the pyrazolo[1.5-a]pyrimidine scaffold of dorsomorphin: the discovery of ML347 as an ALK2 versus ALK3 selective MLPCN probe. Bioorg Med Chem Lett. 2013 Jun 1;23(11):3248-52. DMSTQGH RU https://pubmed.ncbi.nlm.nih.gov/23639540 DMSTQGH DI DMSTQGH DMSTQGH DN PMID23639540C13d DMSTQGH MI TTJNBQA DMSTQGH MN Activin receptor-like kinase 2 (ALK-2) DMSTQGH MT DTT DMSTQGH MA Inhibitor DMSTQGH RN Synthesis and structure-activity relationships of a novel and selective bone morphogenetic protein receptor (BMP) inhibitor derived from the pyrazolo[1.5-a]pyrimidine scaffold of dorsomorphin: the discovery of ML347 as an ALK2 versus ALK3 selective MLPCN probe. Bioorg Med Chem Lett. 2013 Jun 1;23(11):3248-52. DMSTQGH RU https://pubmed.ncbi.nlm.nih.gov/23639540 DMSTQGH DI DMSTQGH DMSTQGH DN PMID23639540C13d DMSTQGH MI TTGYPTC DMSTQGH MN Activin receptor-like kinase-1 (ACVRL1) DMSTQGH MT DTT DMSTQGH MA Inhibitor DMSTQGH RN Synthesis and structure-activity relationships of a novel and selective bone morphogenetic protein receptor (BMP) inhibitor derived from the pyrazolo[1.5-a]pyrimidine scaffold of dorsomorphin: the discovery of ML347 as an ALK2 versus ALK3 selective MLPCN probe. Bioorg Med Chem Lett. 2013 Jun 1;23(11):3248-52. DMSTQGH RU https://pubmed.ncbi.nlm.nih.gov/23639540 DMSTQGH DI DMSTQGH DMSTQGH DN PMID23639540C13d DMSTQGH MI TTGKF90 DMSTQGH MN Bone morphogenetic protein receptor (BMPR2) DMSTQGH MT DTT DMSTQGH MA Inhibitor DMSTQGH RN Synthesis and structure-activity relationships of a novel and selective bone morphogenetic protein receptor (BMP) inhibitor derived from the pyrazolo[1.5-a]pyrimidine scaffold of dorsomorphin: the discovery of ML347 as an ALK2 versus ALK3 selective MLPCN probe. Bioorg Med Chem Lett. 2013 Jun 1;23(11):3248-52. DMSTQGH RU https://pubmed.ncbi.nlm.nih.gov/23639540 DMSTQGH DI DMSTQGH DMSTQGH DN PMID23639540C13d DMSTQGH MI TTP4520 DMSTQGH MN TGF-beta receptor type I (TGFBR1) DMSTQGH MT DTT DMSTQGH MA Inhibitor DMSTQGH RN Synthesis and structure-activity relationships of a novel and selective bone morphogenetic protein receptor (BMP) inhibitor derived from the pyrazolo[1.5-a]pyrimidine scaffold of dorsomorphin: the discovery of ML347 as an ALK2 versus ALK3 selective MLPCN probe. Bioorg Med Chem Lett. 2013 Jun 1;23(11):3248-52. DMSTQGH RU https://pubmed.ncbi.nlm.nih.gov/23639540 DMSTQGH DI DMSTQGH DMSTQGH DN PMID23639540C13d DMSTQGH MI TTZE3P7 DMSTQGH MN TGF-beta receptor type II (TGFBR2) DMSTQGH MT DTT DMSTQGH MA Inhibitor DMSTQGH RN Synthesis and structure-activity relationships of a novel and selective bone morphogenetic protein receptor (BMP) inhibitor derived from the pyrazolo[1.5-a]pyrimidine scaffold of dorsomorphin: the discovery of ML347 as an ALK2 versus ALK3 selective MLPCN probe. Bioorg Med Chem Lett. 2013 Jun 1;23(11):3248-52. DMSTQGH RU https://pubmed.ncbi.nlm.nih.gov/23639540 DMHBZ0N DI DMHBZ0N DMHBZ0N DN PMID23639540C13r DMHBZ0N MI TTPKHTZ DMHBZ0N MN Activin receptor type IB (ACVR1B) DMHBZ0N MT DTT DMHBZ0N MA Inhibitor DMHBZ0N RN Synthesis and structure-activity relationships of a novel and selective bone morphogenetic protein receptor (BMP) inhibitor derived from the pyrazolo[1.5-a]pyrimidine scaffold of dorsomorphin: the discovery of ML347 as an ALK2 versus ALK3 selective MLPCN probe. Bioorg Med Chem Lett. 2013 Jun 1;23(11):3248-52. DMHBZ0N RU https://pubmed.ncbi.nlm.nih.gov/23639540 DMHBZ0N DI DMHBZ0N DMHBZ0N DN PMID23639540C13r DMHBZ0N MI TTJNBQA DMHBZ0N MN Activin receptor-like kinase 2 (ALK-2) DMHBZ0N MT DTT DMHBZ0N MA Inhibitor DMHBZ0N RN Synthesis and structure-activity relationships of a novel and selective bone morphogenetic protein receptor (BMP) inhibitor derived from the pyrazolo[1.5-a]pyrimidine scaffold of dorsomorphin: the discovery of ML347 as an ALK2 versus ALK3 selective MLPCN probe. Bioorg Med Chem Lett. 2013 Jun 1;23(11):3248-52. DMHBZ0N RU https://pubmed.ncbi.nlm.nih.gov/23639540 DMHBZ0N DI DMHBZ0N DMHBZ0N DN PMID23639540C13r DMHBZ0N MI TTGYPTC DMHBZ0N MN Activin receptor-like kinase-1 (ACVRL1) DMHBZ0N MT DTT DMHBZ0N MA Inhibitor DMHBZ0N RN Synthesis and structure-activity relationships of a novel and selective bone morphogenetic protein receptor (BMP) inhibitor derived from the pyrazolo[1.5-a]pyrimidine scaffold of dorsomorphin: the discovery of ML347 as an ALK2 versus ALK3 selective MLPCN probe. Bioorg Med Chem Lett. 2013 Jun 1;23(11):3248-52. DMHBZ0N RU https://pubmed.ncbi.nlm.nih.gov/23639540 DMHBZ0N DI DMHBZ0N DMHBZ0N DN PMID23639540C13r DMHBZ0N MI TTGKF90 DMHBZ0N MN Bone morphogenetic protein receptor (BMPR2) DMHBZ0N MT DTT DMHBZ0N MA Inhibitor DMHBZ0N RN Synthesis and structure-activity relationships of a novel and selective bone morphogenetic protein receptor (BMP) inhibitor derived from the pyrazolo[1.5-a]pyrimidine scaffold of dorsomorphin: the discovery of ML347 as an ALK2 versus ALK3 selective MLPCN probe. Bioorg Med Chem Lett. 2013 Jun 1;23(11):3248-52. DMHBZ0N RU https://pubmed.ncbi.nlm.nih.gov/23639540 DMHBZ0N DI DMHBZ0N DMHBZ0N DN PMID23639540C13r DMHBZ0N MI TTP4520 DMHBZ0N MN TGF-beta receptor type I (TGFBR1) DMHBZ0N MT DTT DMHBZ0N MA Inhibitor DMHBZ0N RN Synthesis and structure-activity relationships of a novel and selective bone morphogenetic protein receptor (BMP) inhibitor derived from the pyrazolo[1.5-a]pyrimidine scaffold of dorsomorphin: the discovery of ML347 as an ALK2 versus ALK3 selective MLPCN probe. Bioorg Med Chem Lett. 2013 Jun 1;23(11):3248-52. DMHBZ0N RU https://pubmed.ncbi.nlm.nih.gov/23639540 DM4JWMA DI DM4JWMA DM4JWMA DN PMID23642479C17 DM4JWMA MI TTE6YDG DM4JWMA MN CDC-like kinase 1 (CLK1) DM4JWMA MT DTT DM4JWMA MA Inhibitor DM4JWMA RN Small-molecule pyrimidine inhibitors of the cdc2-like (Clk) and dual specificity tyrosine phosphorylation-regulated (Dyrk) kinases: development of chemical probe ML315. Bioorg Med Chem Lett. 2013 Jun15;23(12):3654-61. DM4JWMA RU https://pubmed.ncbi.nlm.nih.gov/23642479 DM4JWMA DI DM4JWMA DM4JWMA DN PMID23642479C17 DM4JWMA MI TT85TPS DM4JWMA MN CDC-like kinase 2 (CLK2) DM4JWMA MT DTT DM4JWMA MA Inhibitor DM4JWMA RN Small-molecule pyrimidine inhibitors of the cdc2-like (Clk) and dual specificity tyrosine phosphorylation-regulated (Dyrk) kinases: development of chemical probe ML315. Bioorg Med Chem Lett. 2013 Jun15;23(12):3654-61. DM4JWMA RU https://pubmed.ncbi.nlm.nih.gov/23642479 DM4JWMA DI DM4JWMA DM4JWMA DN PMID23642479C17 DM4JWMA MI TT1RFQP DM4JWMA MN CDC-like kinase 4 (CLK4) DM4JWMA MT DTT DM4JWMA MA Inhibitor DM4JWMA RN Small-molecule pyrimidine inhibitors of the cdc2-like (Clk) and dual specificity tyrosine phosphorylation-regulated (Dyrk) kinases: development of chemical probe ML315. Bioorg Med Chem Lett. 2013 Jun15;23(12):3654-61. DM4JWMA RU https://pubmed.ncbi.nlm.nih.gov/23642479 DM4JWMA DI DM4JWMA DM4JWMA DN PMID23642479C17 DM4JWMA MI TTSBVFO DM4JWMA MN Dual-specificity tyrosine-phosphorylation regulated kinase 1A (DYRK1A) DM4JWMA MT DTT DM4JWMA MA Inhibitor DM4JWMA RN Small-molecule pyrimidine inhibitors of the cdc2-like (Clk) and dual specificity tyrosine phosphorylation-regulated (Dyrk) kinases: development of chemical probe ML315. Bioorg Med Chem Lett. 2013 Jun15;23(12):3654-61. DM4JWMA RU https://pubmed.ncbi.nlm.nih.gov/23642479 DM4JWMA DI DM4JWMA DM4JWMA DN PMID23642479C17 DM4JWMA MI TTYGQ8A DM4JWMA MN Dual-specificity tyrosine-phosphorylation regulated kinase 1B (DYRK1B) DM4JWMA MT DTT DM4JWMA MA Inhibitor DM4JWMA RN Small-molecule pyrimidine inhibitors of the cdc2-like (Clk) and dual specificity tyrosine phosphorylation-regulated (Dyrk) kinases: development of chemical probe ML315. Bioorg Med Chem Lett. 2013 Jun15;23(12):3654-61. DM4JWMA RU https://pubmed.ncbi.nlm.nih.gov/23642479 DM1T9LJ DI DM1T9LJ DM1T9LJ DN PMID23692593C20 DM1T9LJ MI TTS78AZ DM1T9LJ MN Prostate specific antigen (KLK3) DM1T9LJ MT DTT DM1T9LJ MA Inhibitor DM1T9LJ RN Structural optimization, biological evaluation, and application of peptidomimetic prostate specific antigen inhibitors. J Med Chem. 2013 Jun 13;56(11):4224-35. DM1T9LJ RU https://pubmed.ncbi.nlm.nih.gov/23692593 DM2FDJN DI DM2FDJN DM2FDJN DN PMID23788657C1754-31 DM2FDJN MI TTOJ1NF DM2FDJN MN FMLP-related receptor I (FPR2) DM2FDJN MT DTT DM2FDJN MA Antagonist DM2FDJN RN Selective agonists and antagonists of formylpeptide receptors: duplex flow cytometry and mixture-based positional scanning libraries. Mol Pharmacol. 2013 Sep;84(3):314-24. DM2FDJN RU https://pubmed.ncbi.nlm.nih.gov/23788657 DMUW3MT DI DMUW3MT DMUW3MT DN PMID23849879C3 DMUW3MT MI TTDA81R DMUW3MT MN Kallikrein-14 (KLK14) DMUW3MT MT DTT DMUW3MT MA Inhibitor DMUW3MT RN 1,2,4-Triazole derivatives as transient inactivators of kallikreins involved in skin diseases. Bioorg Med Chem Lett. 2013 Aug 15;23(16):4547-51. DMUW3MT RU https://pubmed.ncbi.nlm.nih.gov/23849879 DMUW3MT DI DMUW3MT DMUW3MT DN PMID23849879C3 DMUW3MT MI TTULSEW DMUW3MT MN Kallikrein-5 (KLK5) DMUW3MT MT DTT DMUW3MT MA Inhibitor DMUW3MT RN 1,2,4-Triazole derivatives as transient inactivators of kallikreins involved in skin diseases. Bioorg Med Chem Lett. 2013 Aug 15;23(16):4547-51. DMUW3MT RU https://pubmed.ncbi.nlm.nih.gov/23849879 DMUW3MT DI DMUW3MT DMUW3MT DN PMID23849879C3 DMUW3MT MI TTE6GTB DMUW3MT MN Kallikrein-7 (KLK7) DMUW3MT MT DTT DMUW3MT MA Inhibitor DMUW3MT RN 1,2,4-Triazole derivatives as transient inactivators of kallikreins involved in skin diseases. Bioorg Med Chem Lett. 2013 Aug 15;23(16):4547-51. DMUW3MT RU https://pubmed.ncbi.nlm.nih.gov/23849879 DMUW3MT DI DMUW3MT DMUW3MT DN PMID23849879C3 DMUW3MT MI TTPRO7W DMUW3MT MN Suppressor of tumorigenicity 14 protein (ST14) DMUW3MT MT DTT DMUW3MT MA Inhibitor DMUW3MT RN 1,2,4-Triazole derivatives as transient inactivators of kallikreins involved in skin diseases. Bioorg Med Chem Lett. 2013 Aug 15;23(16):4547-51. DMUW3MT RU https://pubmed.ncbi.nlm.nih.gov/23849879 DM35FH8 DI DM35FH8 DM35FH8 DN PMID23916253C17 DM35FH8 MI TT60XFL DM35FH8 MN Adipocyte-derived leucine aminopeptidase (ERAP1) DM35FH8 MT DTT DM35FH8 MA Inhibitor DM35FH8 RN Novel selective inhibitors of aminopeptidases that generate antigenic peptides. Bioorg Med Chem Lett. 2013 Sep 1;23(17):4832-6. DM35FH8 RU https://pubmed.ncbi.nlm.nih.gov/23916253 DM35FH8 DI DM35FH8 DM35FH8 DN PMID23916253C17 DM35FH8 MI TTVGS1C DM35FH8 MN Endoplasmic reticulum aminopeptidase 2 (ERAP2) DM35FH8 MT DTT DM35FH8 MA Inhibitor DM35FH8 RN Novel selective inhibitors of aminopeptidases that generate antigenic peptides. Bioorg Med Chem Lett. 2013 Sep 1;23(17):4832-6. DM35FH8 RU https://pubmed.ncbi.nlm.nih.gov/23916253 DM35FH8 DI DM35FH8 DM35FH8 DN PMID23916253C17 DM35FH8 MI TTY2KP7 DM35FH8 MN Leucyl-cysteinyl aminopeptidase (LNPEP) DM35FH8 MT DTT DM35FH8 MA Inhibitor DM35FH8 RN Novel selective inhibitors of aminopeptidases that generate antigenic peptides. Bioorg Med Chem Lett. 2013 Sep 1;23(17):4832-6. DM35FH8 RU https://pubmed.ncbi.nlm.nih.gov/23916253 DMHUWZS DI DMHUWZS DMHUWZS DN PMID24000170C36 DMHUWZS MI TTDP48B DMHUWZS MN Bromodomain-containing protein 2 (BRD2) DMHUWZS MT DTT DMHUWZS MA Inhibitor DMHUWZS RN Naphthyridines as novel BET family bromodomain inhibitors. ChemMedChem. 2014 Mar;9(3):580-9. DMHUWZS RU https://pubmed.ncbi.nlm.nih.gov/24000170 DMHUWZS DI DMHUWZS DMHUWZS DN PMID24000170C36 DMHUWZS MI TTHE657 DMHUWZS MN Bromodomain-containing protein 3 (BRD3) DMHUWZS MT DTT DMHUWZS MA Inhibitor DMHUWZS RN Naphthyridines as novel BET family bromodomain inhibitors. ChemMedChem. 2014 Mar;9(3):580-9. DMHUWZS RU https://pubmed.ncbi.nlm.nih.gov/24000170 DMHUWZS DI DMHUWZS DMHUWZS DN PMID24000170C36 DMHUWZS MI TTRA6BO DMHUWZS MN Bromodomain-containing protein 4 (BRD4) DMHUWZS MT DTT DMHUWZS MA Inhibitor DMHUWZS RN Naphthyridines as novel BET family bromodomain inhibitors. ChemMedChem. 2014 Mar;9(3):580-9. DMHUWZS RU https://pubmed.ncbi.nlm.nih.gov/24000170 DMOLRIY DI DMOLRIY DMOLRIY DN PMID24000170C38 DMOLRIY MI TTDP48B DMOLRIY MN Bromodomain-containing protein 2 (BRD2) DMOLRIY MT DTT DMOLRIY MA Inhibitor DMOLRIY RN Naphthyridines as novel BET family bromodomain inhibitors. ChemMedChem. 2014 Mar;9(3):580-9. DMOLRIY RU https://pubmed.ncbi.nlm.nih.gov/24000170 DMOLRIY DI DMOLRIY DMOLRIY DN PMID24000170C38 DMOLRIY MI TTHE657 DMOLRIY MN Bromodomain-containing protein 3 (BRD3) DMOLRIY MT DTT DMOLRIY MA Inhibitor DMOLRIY RN Naphthyridines as novel BET family bromodomain inhibitors. ChemMedChem. 2014 Mar;9(3):580-9. DMOLRIY RU https://pubmed.ncbi.nlm.nih.gov/24000170 DMOLRIY DI DMOLRIY DMOLRIY DN PMID24000170C38 DMOLRIY MI TTRA6BO DMOLRIY MN Bromodomain-containing protein 4 (BRD4) DMOLRIY MT DTT DMOLRIY MA Inhibitor DMOLRIY RN Naphthyridines as novel BET family bromodomain inhibitors. ChemMedChem. 2014 Mar;9(3):580-9. DMOLRIY RU https://pubmed.ncbi.nlm.nih.gov/24000170 DML4KMP DI DML4KMP DML4KMP DN PMID24044867C8 DML4KMP MI TTETX6Q DML4KMP MN Mixed lineage kinase 3 (MAP3K11) DML4KMP MT DTT DML4KMP MA Inhibitor DML4KMP RN Discovery, synthesis, and characterization of an orally bioavailable, brain penetrant inhibitor of mixed lineage kinase 3. J Med Chem. 2013 Oct 24;56(20):8032-48. DML4KMP RU https://pubmed.ncbi.nlm.nih.gov/24044867 DMWOHAE DI DMWOHAE DMWOHAE DN PMID24099220C5i DMWOHAE MI TTZJYKH DMWOHAE MN Indoleamine 2,3-dioxygenase 1 (IDO1) DMWOHAE MT DTT DMWOHAE MA Inhibitor DMWOHAE RN Discovery of tryptanthrin derivatives as potent inhibitors of indoleamine 2,3-dioxygenase with therapeutic activity in Lewis lung cancer (LLC) tumor-bearing mice. J Med Chem. 2013 Nov 14;56(21):8321-31. DMWOHAE RU https://pubmed.ncbi.nlm.nih.gov/24099220 DMWUZP1 DI DMWUZP1 DMWUZP1 DN PMID24157366C35 DMWUZP1 MI TTTJZ4M DMWUZP1 MN Prolylcarboxypeptidase (PRCP) DMWUZP1 MT DTT DMWUZP1 MA Inhibitor DMWUZP1 RN Discovery and optimization of orally active cyclohexane-based prolylcarboxypeptidase (PrCP) inhibitors. Bioorg Med Chem Lett. 2013 Dec 1;23(23):6228-33. DMWUZP1 RU https://pubmed.ncbi.nlm.nih.gov/24157366 DM4LEUT DI DM4LEUT DM4LEUT DN PMID24210504C1o DM4LEUT MI TTAZ3MN DM4LEUT MN Beta-adrenergic receptor kinase 1 (ADRBK1) DM4LEUT MT DTT DM4LEUT MA Inhibitor DM4LEUT RN Design and synthesis of novel 3-(benzo[d]oxazol-2-yl)-5-(1-(piperidin-4-yl)-1H-pyrazol-4-yl)pyridin-2-amine derivatives as selective G-protein-coupled receptor kinase-2 and -5 inhibitors. Bioorg Med Chem Lett. 2013 Dec 15;23(24):6711-6. DM4LEUT RU https://pubmed.ncbi.nlm.nih.gov/24210504 DM4LEUT DI DM4LEUT DM4LEUT DN PMID24210504C1o DM4LEUT MI TTTCXO0 DM4LEUT MN G protein-coupled receptor kinase 5 (GRK5) DM4LEUT MT DTT DM4LEUT MA Inhibitor DM4LEUT RN Design and synthesis of novel 3-(benzo[d]oxazol-2-yl)-5-(1-(piperidin-4-yl)-1H-pyrazol-4-yl)pyridin-2-amine derivatives as selective G-protein-coupled receptor kinase-2 and -5 inhibitors. Bioorg Med Chem Lett. 2013 Dec 15;23(24):6711-6. DM4LEUT RU https://pubmed.ncbi.nlm.nih.gov/24210504 DM4LEUT DI DM4LEUT DM4LEUT DN PMID24210504C1o DM4LEUT MI TTNDSF4 DM4LEUT MN Proto-oncogene c-Met (MET) DM4LEUT MT DTT DM4LEUT MA Inhibitor DM4LEUT RN Design and synthesis of novel 3-(benzo[d]oxazol-2-yl)-5-(1-(piperidin-4-yl)-1H-pyrazol-4-yl)pyridin-2-amine derivatives as selective G-protein-coupled receptor kinase-2 and -5 inhibitors. Bioorg Med Chem Lett. 2013 Dec 15;23(24):6711-6. DM4LEUT RU https://pubmed.ncbi.nlm.nih.gov/24210504 DM26JYS DI DM26JYS DM26JYS DN PMID24359159C19a DM26JYS MI TT6DM01 DM26JYS MN Janus kinase 1 (JAK-1) DM26JYS MT DTT DM26JYS MA Inhibitor DM26JYS RN Discovery of 1-methyl-1H-imidazole derivatives as potent Jak2 inhibitors. J Med Chem. 2014 Jan 9;57(1):144-58. DM26JYS RU https://pubmed.ncbi.nlm.nih.gov/24359159 DM26JYS DI DM26JYS DM26JYS DN PMID24359159C19a DM26JYS MI TTRMX3V DM26JYS MN Janus kinase 2 (JAK-2) DM26JYS MT DTT DM26JYS MA Inhibitor DM26JYS RN Discovery of 1-methyl-1H-imidazole derivatives as potent Jak2 inhibitors. J Med Chem. 2014 Jan 9;57(1):144-58. DM26JYS RU https://pubmed.ncbi.nlm.nih.gov/24359159 DM26JYS DI DM26JYS DM26JYS DN PMID24359159C19a DM26JYS MI TTT7PJU DM26JYS MN Janus kinase 3 (JAK-3) DM26JYS MT DTT DM26JYS MA Inhibitor DM26JYS RN Discovery of 1-methyl-1H-imidazole derivatives as potent Jak2 inhibitors. J Med Chem. 2014 Jan 9;57(1):144-58. DM26JYS RU https://pubmed.ncbi.nlm.nih.gov/24359159 DM6O7MK DI DM6O7MK DM6O7MK DN PMID24412111C9f DM6O7MK MI TTHYDUM DM6O7MK MN Bombesin receptor (BS) DM6O7MK MT DTT DM6O7MK MA Agonist DM6O7MK RN Discovery of novel chiral diazepines as bombesin receptor subtype-3 (BRS-3) agonists with low brain penetration. Bioorg Med Chem Lett. 2014 Feb 1;24(3):750-5. DM6O7MK RU https://pubmed.ncbi.nlm.nih.gov/24412111 DM8JQL4 DI DM8JQL4 DM8JQL4 DN PMID24412111C9g DM8JQL4 MI TTHYDUM DM8JQL4 MN Bombesin receptor (BS) DM8JQL4 MT DTT DM8JQL4 MA Agonist DM8JQL4 RN Discovery of novel chiral diazepines as bombesin receptor subtype-3 (BRS-3) agonists with low brain penetration. Bioorg Med Chem Lett. 2014 Feb 1;24(3):750-5. DM8JQL4 RU https://pubmed.ncbi.nlm.nih.gov/24412111 DMG4NQV DI DMG4NQV DMG4NQV DN PMID24418773C37 DMG4NQV MI TTZUXYS DMG4NQV MN Vitamin K-dependent protein C (PROC) DMG4NQV MT DTT DMG4NQV MA Inhibitor DMG4NQV RN Design, synthesis, and SAR of a series of activated protein C (APC) inhibitors with selectivity against thrombin for the treatment of haemophilia. Bioorg Med Chem Lett. 2014 Feb 1;24(3):821-7. DMG4NQV RU https://pubmed.ncbi.nlm.nih.gov/24418773 DMEGAZS DI DMEGAZS DMEGAZS DN PMID24432909C8e DMEGAZS MI TTPMQSO DMEGAZS MN ALK tyrosine kinase receptor (ALK) DMEGAZS MT DTT DMEGAZS MA Inhibitor DMEGAZS RN Design of potent and selective inhibitors to overcome clinical anaplastic lymphoma kinase mutations resistant to crizotinib. J Med Chem.> 2014 Feb 27;57(4):1170-87. DMEGAZS RU https://pubmed.ncbi.nlm.nih.gov/24432909 DMEGAZS DI DMEGAZS DMEGAZS DN PMID24432909C8e DMEGAZS MI TTKN7QR DMEGAZS MN BDNF/NT-3 growth factors receptor (TrkB) DMEGAZS MT DTT DMEGAZS MA Inhibitor DMEGAZS RN Design of potent and selective inhibitors to overcome clinical anaplastic lymphoma kinase mutations resistant to crizotinib. J Med Chem.> 2014 Feb 27;57(4):1170-87. DMEGAZS RU https://pubmed.ncbi.nlm.nih.gov/24432909 DMEGAZS DI DMEGAZS DMEGAZS DN PMID24432909C8e DMEGAZS MI TT1JZG6 DMEGAZS MN Leukocyte receptor tyrosine kinase (LTK) DMEGAZS MT DTT DMEGAZS MA Inhibitor DMEGAZS RN Design of potent and selective inhibitors to overcome clinical anaplastic lymphoma kinase mutations resistant to crizotinib. J Med Chem.> 2014 Feb 27;57(4):1170-87. DMEGAZS RU https://pubmed.ncbi.nlm.nih.gov/24432909 DMEGAZS DI DMEGAZS DMEGAZS DN PMID24432909C8e DMEGAZS MI TTRA9G0 DMEGAZS MN Proto-oncogene c-Fer (FER) DMEGAZS MT DTT DMEGAZS MA Inhibitor DMEGAZS RN Design of potent and selective inhibitors to overcome clinical anaplastic lymphoma kinase mutations resistant to crizotinib. J Med Chem.> 2014 Feb 27;57(4):1170-87. DMEGAZS RU https://pubmed.ncbi.nlm.nih.gov/24432909 DMEGAZS DI DMEGAZS DMEGAZS DN PMID24432909C8e DMEGAZS MI TTLBY21 DMEGAZS MN Proto-oncogene c-Fes (FES) DMEGAZS MT DTT DMEGAZS MA Inhibitor DMEGAZS RN Design of potent and selective inhibitors to overcome clinical anaplastic lymphoma kinase mutations resistant to crizotinib. J Med Chem.> 2014 Feb 27;57(4):1170-87. DMEGAZS RU https://pubmed.ncbi.nlm.nih.gov/24432909 DMEGAZS DI DMEGAZS DMEGAZS DN PMID24432909C8e DMEGAZS MI TTSZ6Y3 DMEGAZS MN Proto-oncogene c-Ros (ROS1) DMEGAZS MT DTT DMEGAZS MA Inhibitor DMEGAZS RN Design of potent and selective inhibitors to overcome clinical anaplastic lymphoma kinase mutations resistant to crizotinib. J Med Chem.> 2014 Feb 27;57(4):1170-87. DMEGAZS RU https://pubmed.ncbi.nlm.nih.gov/24432909 DMHQK54 DI DMHQK54 DMHQK54 DN PMID24440480C3 DMHQK54 MI TTSCHFW DMHQK54 MN Peptidyl arginine deiminase type III (PADI3) DMHQK54 MT DTT DMHQK54 MA Inhibitor DMHQK54 RN Insights into the mechanism of streptonigrin-induced protein arginine deiminase inactivation. Bioorg Med Chem. 2014 Feb 15;22(4):1362-9. DMHQK54 RU https://pubmed.ncbi.nlm.nih.gov/24440480 DMHQK54 DI DMHQK54 DMHQK54 DN PMID24440480C3 DMHQK54 MI TTQHAXM DMHQK54 MN Peptidyl arginine deiminase type IV (PADI4) DMHQK54 MT DTT DMHQK54 MA Inhibitor DMHQK54 RN Insights into the mechanism of streptonigrin-induced protein arginine deiminase inactivation. Bioorg Med Chem. 2014 Feb 15;22(4):1362-9. DMHQK54 RU https://pubmed.ncbi.nlm.nih.gov/24440480 DMK6GAU DI DMK6GAU DMK6GAU DN PMID24556381C10f DMK6GAU MI TTTRNQW DMK6GAU MN Bile-salt-activated lipase (CEL) DMK6GAU MT DTT DMK6GAU MA Inhibitor DMK6GAU RN Synthesis and evaluation of 2-(1H-indol-3-yl)-4-phenylquinolines as inhibitors of cholesterol esterase. Bioorg Med Chem Lett. 2014 Mar 15;24(6):1545-9. DMK6GAU RU https://pubmed.ncbi.nlm.nih.gov/24556381 DMK6GAU DI DMK6GAU DMK6GAU DN PMID24556381C10f DMK6GAU MI TTPLTSQ DMK6GAU MN Neutrophil elastase (NE) DMK6GAU MT DTT DMK6GAU MA Inhibitor DMK6GAU RN Synthesis and evaluation of 2-(1H-indol-3-yl)-4-phenylquinolines as inhibitors of cholesterol esterase. Bioorg Med Chem Lett. 2014 Mar 15;24(6):1545-9. DMK6GAU RU https://pubmed.ncbi.nlm.nih.gov/24556381 DMOH45T DI DMOH45T DMOH45T DN PMID24556381C10l DMOH45T MI TTTRNQW DMOH45T MN Bile-salt-activated lipase (CEL) DMOH45T MT DTT DMOH45T MA Inhibitor DMOH45T RN Synthesis and evaluation of 2-(1H-indol-3-yl)-4-phenylquinolines as inhibitors of cholesterol esterase. Bioorg Med Chem Lett. 2014 Mar 15;24(6):1545-9. DMOH45T RU https://pubmed.ncbi.nlm.nih.gov/24556381 DMOH45T DI DMOH45T DMOH45T DN PMID24556381C10l DMOH45T MI TTPLTSQ DMOH45T MN Neutrophil elastase (NE) DMOH45T MT DTT DMOH45T MA Inhibitor DMOH45T RN Synthesis and evaluation of 2-(1H-indol-3-yl)-4-phenylquinolines as inhibitors of cholesterol esterase. Bioorg Med Chem Lett. 2014 Mar 15;24(6):1545-9. DMOH45T RU https://pubmed.ncbi.nlm.nih.gov/24556381 DM2HVU8 DI DM2HVU8 DM2HVU8 DN PMID24673130C26 DM2HVU8 MI TT6NI13 DM2HVU8 MN MEK kinase kinase 4 (MAP4K4) DM2HVU8 MT DTT DM2HVU8 MA Inhibitor DM2HVU8 RN Discovery of selective 4-Amino-pyridopyrimidine inhibitors of MAP4K4 using fragment-based lead identification and optimization. J Med Chem. 2014 Apr 24;57(8):3484-93. DM2HVU8 RU https://pubmed.ncbi.nlm.nih.gov/24673130 DMJNQE1 DI DMJNQE1 DMJNQE1 DN PMID24749861C34 DMJNQE1 MI TTOJ9QL DMJNQE1 MN Endoplasmic reticulum to nucleus signaling 1 (ERN1) DMJNQE1 MT DTT DMJNQE1 MA Inhibitor DMJNQE1 RN Synthesis of novel tricyclic chromenone-based inhibitors of IRE-1 RNase activity. J Med Chem. 2014 May 22;57(10):4289-301. DMJNQE1 RU https://pubmed.ncbi.nlm.nih.gov/24749861 DMDMU01 DI DMDMU01 DMDMU01 DN PMID24775305C7u DMDMU01 MI TTPTWV5 DMDMU01 MN Legumain (LGMN) DMDMU01 MT DTT DMDMU01 MA Inhibitor DMDMU01 RN P3 SAR exploration of biphenyl carbamate based Legumain inhibitors. Bioorg Med Chem Lett. 2014 Jun 1;24(11):2521-4. DMDMU01 RU https://pubmed.ncbi.nlm.nih.gov/24775305 DMFSJQC DI DMFSJQC DMFSJQC DN PMID24793884C74 DMFSJQC MI TTSMTDI DMFSJQC MN CDC7-related kinase (CDC7) DMFSJQC MT DTT DMFSJQC MA Inhibitor DMFSJQC RN Synthesis and structure-activity relationship of trisubstituted thiazoles as Cdc7 kinase inhibitors. Eur J Med Chem. 2014 Jun 10;80:364-82. DMFSJQC RU https://pubmed.ncbi.nlm.nih.gov/24793884 DMFSJQC DI DMFSJQC DMFSJQC DN PMID24793884C74 DMFSJQC MI TT7ZY03 DMFSJQC MN Oxidative stress responsive 1 (OXSR1) DMFSJQC MT DTT DMFSJQC MA Inhibitor DMFSJQC RN Synthesis and structure-activity relationship of trisubstituted thiazoles as Cdc7 kinase inhibitors. Eur J Med Chem. 2014 Jun 10;80:364-82. DMFSJQC RU https://pubmed.ncbi.nlm.nih.gov/24793884 DMFSJQC DI DMFSJQC DMFSJQC DN PMID24793884C74 DMFSJQC MI TT4D2GZ DMFSJQC MN Yet another novel kinase 2 (STK32B) DMFSJQC MT DTT DMFSJQC MA Inhibitor DMFSJQC RN Synthesis and structure-activity relationship of trisubstituted thiazoles as Cdc7 kinase inhibitors. Eur J Med Chem. 2014 Jun 10;80:364-82. DMFSJQC RU https://pubmed.ncbi.nlm.nih.gov/24793884 DMZENGX DI DMZENGX DMZENGX DN PMID24793884C77 DMZENGX MI TTSMTDI DMZENGX MN CDC7-related kinase (CDC7) DMZENGX MT DTT DMZENGX MA Inhibitor DMZENGX RN Synthesis and structure-activity relationship of trisubstituted thiazoles as Cdc7 kinase inhibitors. Eur J Med Chem. 2014 Jun 10;80:364-82. DMZENGX RU https://pubmed.ncbi.nlm.nih.gov/24793884 DMZENGX DI DMZENGX DMZENGX DN PMID24793884C77 DMZENGX MI TTUMFAR DMZENGX MN Cyclin-dependent kinase 18 (CDK18) DMZENGX MT DTT DMZENGX MA Inhibitor DMZENGX RN Synthesis and structure-activity relationship of trisubstituted thiazoles as Cdc7 kinase inhibitors. Eur J Med Chem. 2014 Jun 10;80:364-82. DMZENGX RU https://pubmed.ncbi.nlm.nih.gov/24793884 DM5G1RP DI DM5G1RP DM5G1RP DN PMID24793972C2 DM5G1RP MI TTMRQY1 DM5G1RP MN Striatum-specific G-protein coupled receptor (GPR88) DM5G1RP MT DTT DM5G1RP MA Agonist DM5G1RP RN Synthesis, pharmacological characterization, and structure-activity relationship studies of small molecular agonists for the orphan GPR88 receptor. ACS Chem Neurosci. 2014 Jul 16;5(7):576-87. DM5G1RP RU https://pubmed.ncbi.nlm.nih.gov/24793972 DMI8T1Y DI DMI8T1Y DMI8T1Y DN PMID24809814C31 DMI8T1Y MI TT618Q2 DMI8T1Y MN Sphingosine-1-phosphate lyase 1 (SGPL1) DMI8T1Y MT DTT DMI8T1Y MA Inhibitor DMI8T1Y RN Orally active 7-substituted (4-benzylphthalazin-1-yl)-2-methylpiperazin-1-yl]nicotinonitriles as active-site inhibitors of sphingosine 1-phosphate lyase for the treatment of multiple sclerosis. J MedChem. 2014 Jun 26;57(12):5074-84. DMI8T1Y RU https://pubmed.ncbi.nlm.nih.gov/24809814 DM6TFPY DI DM6TFPY DM6TFPY DN PMID24900237C15 DM6TFPY MI TTPMQSO DM6TFPY MN ALK tyrosine kinase receptor (ALK) DM6TFPY MT DTT DM6TFPY MA Inhibitor DM6TFPY RN Discovery of a potent inhibitor of anaplastic lymphoma kinase with in vivo antitumor activity. ACS Med Chem Lett. 2010 Sep 1;1(9):493-8. DM6TFPY RU https://pubmed.ncbi.nlm.nih.gov/24900237 DM6TFPY DI DM6TFPY DM6TFPY DN PMID24900237C15 DM6TFPY MI TTCBFJO DM6TFPY MN Insulin receptor (INSR) DM6TFPY MT DTT DM6TFPY MA Inhibitor DM6TFPY RN Discovery of a potent inhibitor of anaplastic lymphoma kinase with in vivo antitumor activity. ACS Med Chem Lett. 2010 Sep 1;1(9):493-8. DM6TFPY RU https://pubmed.ncbi.nlm.nih.gov/24900237 DM6TFPY DI DM6TFPY DM6TFPY DN PMID24900237C15 DM6TFPY MI TTYENHQ DM6TFPY MN Unc-51 like kinase 3 (ULK3) DM6TFPY MT DTT DM6TFPY MA Inhibitor DM6TFPY RN Discovery of a potent inhibitor of anaplastic lymphoma kinase with in vivo antitumor activity. ACS Med Chem Lett. 2010 Sep 1;1(9):493-8. DM6TFPY RU https://pubmed.ncbi.nlm.nih.gov/24900237 DM6TYD0 DI DM6TYD0 DM6TYD0 DN PMID24900283C8a DM6TYD0 MI TTHYDUM DM6TYD0 MN Bombesin receptor (BS) DM6TYD0 MT DTT DM6TYD0 MA Agonist DM6TYD0 RN Discovery of benzodiazepine sulfonamide-based bombesin receptor subtype 3 agonists and their unusual chirality. ACS Med Chem Lett. 2011 Oct 3;2(12):933-7. DM6TYD0 RU https://pubmed.ncbi.nlm.nih.gov/24900283 DMJS0F5 DI DMJS0F5 DMJS0F5 DN PMID24900311C1a DMJS0F5 MI TTOL9B0 DMJS0F5 MN G-protein-coupled receptor PGR3 (GPR139) DMJS0F5 MT DTT DMJS0F5 MA Agonist DMJS0F5 RN Discovery and SAR of a Series of Agonists at Orphan G Protein-Coupled Receptor 139. ACS Med Chem Lett. 2011 Feb 28;2(4):303-6. DMJS0F5 RU https://pubmed.ncbi.nlm.nih.gov/24900311 DMU4BL2 DI DMU4BL2 DMU4BL2 DN PMID24900428C14 DMU4BL2 MI TTFQEMX DMU4BL2 MN Casein kinase I alpha (CSNK1A1) DMU4BL2 MT DTT DMU4BL2 MA Inhibitor DMU4BL2 RN Structure-Based Design of Potent and Selective CK1gamma Inhibitors. ACS Med Chem Lett. 2012 Oct 18;3(12):1059-64. DMU4BL2 RU https://pubmed.ncbi.nlm.nih.gov/24900428 DMU4BL2 DI DMU4BL2 DMU4BL2 DN PMID24900428C14 DMU4BL2 MI TTH30UI DMU4BL2 MN Casein kinase I delta (CSNK1D) DMU4BL2 MT DTT DMU4BL2 MA Inhibitor DMU4BL2 RN Structure-Based Design of Potent and Selective CK1gamma Inhibitors. ACS Med Chem Lett. 2012 Oct 18;3(12):1059-64. DMU4BL2 RU https://pubmed.ncbi.nlm.nih.gov/24900428 DMU4BL2 DI DMU4BL2 DMU4BL2 DN PMID24900428C14 DMU4BL2 MI TT0UZJ9 DMU4BL2 MN Casein kinase I gamma-2 (CSNK1G2) DMU4BL2 MT DTT DMU4BL2 MA Inhibitor DMU4BL2 RN Structure-Based Design of Potent and Selective CK1gamma Inhibitors. ACS Med Chem Lett. 2012 Oct 18;3(12):1059-64. DMU4BL2 RU https://pubmed.ncbi.nlm.nih.gov/24900428 DMZ5P2K DI DMZ5P2K DMZ5P2K DN PMID24900446C5 DMZ5P2K MI TTLPF4X DMZ5P2K MN Kallikrein-6 (KLK6) DMZ5P2K MT DTT DMZ5P2K MA Inhibitor DMZ5P2K RN Virtual Screening and X-ray Crystallography for Human Kallikrein 6 Inhibitors with an Amidinothiophene P1 Group. ACS Med Chem Lett. 2012 Jan 11;3(2):159-64. DMZ5P2K RU https://pubmed.ncbi.nlm.nih.gov/24900446 DMEWVG8 DI DMEWVG8 DMEWVG8 DN PMID24900526C1 DMEWVG8 MI TTXZ0KQ DMEWVG8 MN Matrix metalloproteinase-12 (MMP-12) DMEWVG8 MT DTT DMEWVG8 MA Inhibitor DMEWVG8 RN Target-Activated Prodrugs (TAPs) for the Autoregulated Inhibition of MMP12. ACS Med Chem Lett. 2012 Jul 14;3(8):653-7. DMEWVG8 RU https://pubmed.ncbi.nlm.nih.gov/24900526 DMKTBCM DI DMKTBCM DMKTBCM DN PMID24900526C5 DMKTBCM MI TTXZ0KQ DMKTBCM MN Matrix metalloproteinase-12 (MMP-12) DMKTBCM MT DTT DMKTBCM MA Inhibitor DMKTBCM RN Target-Activated Prodrugs (TAPs) for the Autoregulated Inhibition of MMP12. ACS Med Chem Lett. 2012 Jul 14;3(8):653-7. DMKTBCM RU https://pubmed.ncbi.nlm.nih.gov/24900526 DM5PATM DI DM5PATM DM5PATM DN PMID24900538C2c DM5PATM MI TT6B75U DM5PATM MN ABL messenger RNA (ABL mRNA) DM5PATM MT DTT DM5PATM MA Inhibitor DM5PATM RN Discovery of Disubstituted Imidazo[4,5-b]pyridines and Purines as Potent TrkA Inhibitors. ACS Med Chem Lett. 2012 Jul 26;3(9):705-9. DM5PATM RU https://pubmed.ncbi.nlm.nih.gov/24900538 DM5PATM DI DM5PATM DM5PATM DN PMID24900538C2c DM5PATM MI TTRLW2X DM5PATM MN Fibroblast growth factor receptor 1 (FGFR1) DM5PATM MT DTT DM5PATM MA Inhibitor DM5PATM RN Discovery of Disubstituted Imidazo[4,5-b]pyridines and Purines as Potent TrkA Inhibitors. ACS Med Chem Lett. 2012 Jul 26;3(9):705-9. DM5PATM RU https://pubmed.ncbi.nlm.nih.gov/24900538 DM5PATM DI DM5PATM DM5PATM DN PMID24900538C2c DM5PATM MI TTGJCWZ DM5PATM MN Fms-like tyrosine kinase 3 (FLT-3) DM5PATM MT DTT DM5PATM MA Inhibitor DM5PATM RN Discovery of Disubstituted Imidazo[4,5-b]pyridines and Purines as Potent TrkA Inhibitors. ACS Med Chem Lett. 2012 Jul 26;3(9):705-9. DM5PATM RU https://pubmed.ncbi.nlm.nih.gov/24900538 DM5PATM DI DM5PATM DM5PATM DN PMID24900538C2c DM5PATM MI TTXABCW DM5PATM MN NT-3 growth factor receptor (TrkC) DM5PATM MT DTT DM5PATM MA Inhibitor DM5PATM RN Discovery of Disubstituted Imidazo[4,5-b]pyridines and Purines as Potent TrkA Inhibitors. ACS Med Chem Lett. 2012 Jul 26;3(9):705-9. DM5PATM RU https://pubmed.ncbi.nlm.nih.gov/24900538 DM5PATM DI DM5PATM DM5PATM DN PMID24900538C2c DM5PATM MI TTI5WS6 DM5PATM MN Phosphorylase kinase testis gamma 2 (PHKG2) DM5PATM MT DTT DM5PATM MA Inhibitor DM5PATM RN Discovery of Disubstituted Imidazo[4,5-b]pyridines and Purines as Potent TrkA Inhibitors. ACS Med Chem Lett. 2012 Jul 26;3(9):705-9. DM5PATM RU https://pubmed.ncbi.nlm.nih.gov/24900538 DM5PATM DI DM5PATM DM5PATM DN PMID24900538C2c DM5PATM MI TT1H6LC DM5PATM MN Salt-inducible kinase 1 (SIK1) DM5PATM MT DTT DM5PATM MA Inhibitor DM5PATM RN Discovery of Disubstituted Imidazo[4,5-b]pyridines and Purines as Potent TrkA Inhibitors. ACS Med Chem Lett. 2012 Jul 26;3(9):705-9. DM5PATM RU https://pubmed.ncbi.nlm.nih.gov/24900538 DM5PATM DI DM5PATM DM5PATM DN PMID24900538C2c DM5PATM MI TTA3Z2W DM5PATM MN Testis-specific serine kinase 2 (TSSK2) DM5PATM MT DTT DM5PATM MA Inhibitor DM5PATM RN Discovery of Disubstituted Imidazo[4,5-b]pyridines and Purines as Potent TrkA Inhibitors. ACS Med Chem Lett. 2012 Jul 26;3(9):705-9. DM5PATM RU https://pubmed.ncbi.nlm.nih.gov/24900538 DM5PATM DI DM5PATM DM5PATM DN PMID24900538C2c DM5PATM MI TTGM6VW DM5PATM MN Tyrosine-protein kinase BTK (ATK) DM5PATM MT DTT DM5PATM MA Inhibitor DM5PATM RN Discovery of Disubstituted Imidazo[4,5-b]pyridines and Purines as Potent TrkA Inhibitors. ACS Med Chem Lett. 2012 Jul 26;3(9):705-9. DM5PATM RU https://pubmed.ncbi.nlm.nih.gov/24900538 DM5PATM DI DM5PATM DM5PATM DN PMID24900538C2c DM5PATM MI TTPOGS1 DM5PATM MN Tyrosine-protein kinase Fgr (FGR) DM5PATM MT DTT DM5PATM MA Inhibitor DM5PATM RN Discovery of Disubstituted Imidazo[4,5-b]pyridines and Purines as Potent TrkA Inhibitors. ACS Med Chem Lett. 2012 Jul 26;3(9):705-9. DM5PATM RU https://pubmed.ncbi.nlm.nih.gov/24900538 DM5PATM DI DM5PATM DM5PATM DN PMID24900538C2c DM5PATM MI TTI7FDX DM5PATM MN WNK lysine-deficient protein kinase 3 (WNK3) DM5PATM MT DTT DM5PATM MA Inhibitor DM5PATM RN Discovery of Disubstituted Imidazo[4,5-b]pyridines and Purines as Potent TrkA Inhibitors. ACS Med Chem Lett. 2012 Jul 26;3(9):705-9. DM5PATM RU https://pubmed.ncbi.nlm.nih.gov/24900538 DMCL6H3 DI DMCL6H3 DMCL6H3 DN PMID24900608C1 DMCL6H3 MI TTTPCNU DMCL6H3 MN G-protein coupled receptor 39 (GPR39) DMCL6H3 MT DTT DMCL6H3 MA Agonist DMCL6H3 RN Chemical Probe Identification Platform for Orphan GPCRs Using Focused Compound Screening: GPR39 as a Case Example. ACS Med Chem Lett. 2013 Sep 16;4(11):1079-84. DMCL6H3 RU https://pubmed.ncbi.nlm.nih.gov/24900608 DM1QDG0 DI DM1QDG0 DM1QDG0 DN PMID24900635C21 DM1QDG0 MI TTAIQSN DM1QDG0 MN Receptor-interacting protein 1 (RIPK1) DM1QDG0 MT DTT DM1QDG0 MA Inhibitor DM1QDG0 RN Discovery of Small Molecule RIP1 Kinase Inhibitors for the Treatment of Pathologies Associated with Necroptosis. ACS Med Chem Lett. 2013 Nov 4;4(12):1238-43. DM1QDG0 RU https://pubmed.ncbi.nlm.nih.gov/24900635 DM2V4MJ DI DM2V4MJ DM2V4MJ DN PMID24900699C68 DM2V4MJ MI TTSBVFO DM2V4MJ MN Dual-specificity tyrosine-phosphorylation regulated kinase 1A (DYRK1A) DM2V4MJ MT DTT DM2V4MJ MA Inhibitor DM2V4MJ RN Tricyclic Pyrimidines As Inhibitors of DYRK1A/DYRK1B As Potential Treatment for Down's Syndrome or Alzheimer's Disease. ACS Med Chem Lett. 2013 Apr 26;4(6):502-3. DM2V4MJ RU https://pubmed.ncbi.nlm.nih.gov/24900699 DM2V4MJ DI DM2V4MJ DM2V4MJ DN PMID24900699C68 DM2V4MJ MI TTYGQ8A DM2V4MJ MN Dual-specificity tyrosine-phosphorylation regulated kinase 1B (DYRK1B) DM2V4MJ MT DTT DM2V4MJ MA Inhibitor DM2V4MJ RN Tricyclic Pyrimidines As Inhibitors of DYRK1A/DYRK1B As Potential Treatment for Down's Syndrome or Alzheimer's Disease. ACS Med Chem Lett. 2013 Apr 26;4(6):502-3. DM2V4MJ RU https://pubmed.ncbi.nlm.nih.gov/24900699 DMZPUSO DI DMZPUSO DMZPUSO DN PMID24900749C1a DMZPUSO MI TTER6YH DMZPUSO MN Casein kinase II alpha (CSNK2A1) DMZPUSO MT DTT DMZPUSO MA Inhibitor DMZPUSO RN Structure and Property Based Design of Pyrazolo[1,5-a]pyrimidine Inhibitors of CK2 Kinase with Activity in Vivo. ACS Med Chem Lett. 2013 Jul 3;4(8):800-5. DMZPUSO RU https://pubmed.ncbi.nlm.nih.gov/24900749 DMZPUSO DI DMZPUSO DMZPUSO DN PMID24900749C1a DMZPUSO MI TTV4EX0 DMZPUSO MN Dual-specificity tyrosine-phosphorylation regulated kinase 3 (DYRK3) DMZPUSO MT DTT DMZPUSO MA Inhibitor DMZPUSO RN Structure and Property Based Design of Pyrazolo[1,5-a]pyrimidine Inhibitors of CK2 Kinase with Activity in Vivo. ACS Med Chem Lett. 2013 Jul 3;4(8):800-5. DMZPUSO RU https://pubmed.ncbi.nlm.nih.gov/24900749 DMZPUSO DI DMZPUSO DMZPUSO DN PMID24900749C1a DMZPUSO MI TTOB49C DMZPUSO MN Homeodomain interacting protein kinase 2 (HIPK2) DMZPUSO MT DTT DMZPUSO MA Inhibitor DMZPUSO RN Structure and Property Based Design of Pyrazolo[1,5-a]pyrimidine Inhibitors of CK2 Kinase with Activity in Vivo. ACS Med Chem Lett. 2013 Jul 3;4(8):800-5. DMZPUSO RU https://pubmed.ncbi.nlm.nih.gov/24900749 DMZPUSO DI DMZPUSO DMZPUSO DN PMID24900749C1a DMZPUSO MI TTCGOIN DMZPUSO MN PIM-3 protein kinase (PIM3) DMZPUSO MT DTT DMZPUSO MA Inhibitor DMZPUSO RN Structure and Property Based Design of Pyrazolo[1,5-a]pyrimidine Inhibitors of CK2 Kinase with Activity in Vivo. ACS Med Chem Lett. 2013 Jul 3;4(8):800-5. DMZPUSO RU https://pubmed.ncbi.nlm.nih.gov/24900749 DMOSMBZ DI DMOSMBZ DMOSMBZ DN PMID24900824C2-1-1 DMOSMBZ MI TT78309 DMOSMBZ MN BUB1 mitotic checkpoint serine/threonine kinase (BUB1) DMOSMBZ MT DTT DMOSMBZ MA Inhibitor DMOSMBZ RN Novel cycloalkenepyrazoles as inhibitors of bub1 kinase. ACS Med Chem Lett. 2014 Feb 12;5(4):280-1. DMOSMBZ RU https://pubmed.ncbi.nlm.nih.gov/24900824 DM2FYUM DI DM2FYUM DM2FYUM DN PMID24900824C2-13-1 DM2FYUM MI TT78309 DM2FYUM MN BUB1 mitotic checkpoint serine/threonine kinase (BUB1) DM2FYUM MT DTT DM2FYUM MA Inhibitor DM2FYUM RN Novel cycloalkenepyrazoles as inhibitors of bub1 kinase. ACS Med Chem Lett. 2014 Feb 12;5(4):280-1. DM2FYUM RU https://pubmed.ncbi.nlm.nih.gov/24900824 DMC5JAT DI DMC5JAT DMC5JAT DN PMID24900824C2-3-1 DMC5JAT MI TT78309 DMC5JAT MN BUB1 mitotic checkpoint serine/threonine kinase (BUB1) DMC5JAT MT DTT DMC5JAT MA Inhibitor DMC5JAT RN Novel cycloalkenepyrazoles as inhibitors of bub1 kinase. ACS Med Chem Lett. 2014 Feb 12;5(4):280-1. DMC5JAT RU https://pubmed.ncbi.nlm.nih.gov/24900824 DMVP0Z9 DI DMVP0Z9 DMVP0Z9 DN PMID24900824C2-3-2 DMVP0Z9 MI TT78309 DMVP0Z9 MN BUB1 mitotic checkpoint serine/threonine kinase (BUB1) DMVP0Z9 MT DTT DMVP0Z9 MA Inhibitor DMVP0Z9 RN Novel cycloalkenepyrazoles as inhibitors of bub1 kinase. ACS Med Chem Lett. 2014 Feb 12;5(4):280-1. DMVP0Z9 RU https://pubmed.ncbi.nlm.nih.gov/24900824 DMN7QB8 DI DMN7QB8 DMN7QB8 DN PMID24915291C31 DMN7QB8 MI TTNDSC3 DMN7QB8 MN B lymphocyte kinase (BLK) DMN7QB8 MT DTT DMN7QB8 MA Inhibitor DMN7QB8 RN Discovery of a series of 2,5-diaminopyrimidine covalent irreversible inhibitors of Bruton's tyrosine kinase with in vivo antitumor activity. J Med Chem. 2014 Jun 26;57(12):5112-28. DMN7QB8 RU https://pubmed.ncbi.nlm.nih.gov/24915291 DMN7QB8 DI DMN7QB8 DMN7QB8 DN PMID24915291C31 DMN7QB8 MI TTN2I9E DMN7QB8 MN Tyrosine-protein kinase BMX (BMX) DMN7QB8 MT DTT DMN7QB8 MA Inhibitor DMN7QB8 RN Discovery of a series of 2,5-diaminopyrimidine covalent irreversible inhibitors of Bruton's tyrosine kinase with in vivo antitumor activity. J Med Chem. 2014 Jun 26;57(12):5112-28. DMN7QB8 RU https://pubmed.ncbi.nlm.nih.gov/24915291 DMN7QB8 DI DMN7QB8 DMN7QB8 DN PMID24915291C31 DMN7QB8 MI TTGM6VW DMN7QB8 MN Tyrosine-protein kinase BTK (ATK) DMN7QB8 MT DTT DMN7QB8 MA Inhibitor DMN7QB8 RN Discovery of a series of 2,5-diaminopyrimidine covalent irreversible inhibitors of Bruton's tyrosine kinase with in vivo antitumor activity. J Med Chem. 2014 Jun 26;57(12):5112-28. DMN7QB8 RU https://pubmed.ncbi.nlm.nih.gov/24915291 DMN7QB8 DI DMN7QB8 DMN7QB8 DN PMID24915291C31 DMN7QB8 MI TT1ZV49 DMN7QB8 MN Tyrosine-protein kinase Tec (PSCTK4) DMN7QB8 MT DTT DMN7QB8 MA Inhibitor DMN7QB8 RN Discovery of a series of 2,5-diaminopyrimidine covalent irreversible inhibitors of Bruton's tyrosine kinase with in vivo antitumor activity. J Med Chem. 2014 Jun 26;57(12):5112-28. DMN7QB8 RU https://pubmed.ncbi.nlm.nih.gov/24915291 DMN7QB8 DI DMN7QB8 DMN7QB8 DN PMID24915291C31 DMN7QB8 MI TT8M1DP DMN7QB8 MN Tyrosine-protein kinase TXK (TXK) DMN7QB8 MT DTT DMN7QB8 MA Inhibitor DMN7QB8 RN Discovery of a series of 2,5-diaminopyrimidine covalent irreversible inhibitors of Bruton's tyrosine kinase with in vivo antitumor activity. J Med Chem. 2014 Jun 26;57(12):5112-28. DMN7QB8 RU https://pubmed.ncbi.nlm.nih.gov/24915291 DMBXT9J DI DMBXT9J DMBXT9J DN PMID24915291C38 DMBXT9J MI TTNDSC3 DMBXT9J MN B lymphocyte kinase (BLK) DMBXT9J MT DTT DMBXT9J MA Inhibitor DMBXT9J RN Discovery of a series of 2,5-diaminopyrimidine covalent irreversible inhibitors of Bruton's tyrosine kinase with in vivo antitumor activity. J Med Chem. 2014 Jun 26;57(12):5112-28. DMBXT9J RU https://pubmed.ncbi.nlm.nih.gov/24915291 DMBXT9J DI DMBXT9J DMBXT9J DN PMID24915291C38 DMBXT9J MI TTGKNB4 DMBXT9J MN Epidermal growth factor receptor (EGFR) DMBXT9J MT DTT DMBXT9J MA Inhibitor DMBXT9J RN Discovery of a series of 2,5-diaminopyrimidine covalent irreversible inhibitors of Bruton's tyrosine kinase with in vivo antitumor activity. J Med Chem. 2014 Jun 26;57(12):5112-28. DMBXT9J RU https://pubmed.ncbi.nlm.nih.gov/24915291 DMBXT9J DI DMBXT9J DMBXT9J DN PMID24915291C38 DMBXT9J MI TTR5TV4 DMBXT9J MN ERBB2 messenger RNA (HER2 mRNA) DMBXT9J MT DTT DMBXT9J MA Inhibitor DMBXT9J RN Discovery of a series of 2,5-diaminopyrimidine covalent irreversible inhibitors of Bruton's tyrosine kinase with in vivo antitumor activity. J Med Chem. 2014 Jun 26;57(12):5112-28. DMBXT9J RU https://pubmed.ncbi.nlm.nih.gov/24915291 DMBXT9J DI DMBXT9J DMBXT9J DN PMID24915291C38 DMBXT9J MI TT0JESD DMBXT9J MN Erbb4 tyrosine kinase receptor (Erbb-4) DMBXT9J MT DTT DMBXT9J MA Inhibitor DMBXT9J RN Discovery of a series of 2,5-diaminopyrimidine covalent irreversible inhibitors of Bruton's tyrosine kinase with in vivo antitumor activity. J Med Chem. 2014 Jun 26;57(12):5112-28. DMBXT9J RU https://pubmed.ncbi.nlm.nih.gov/24915291 DMBXT9J DI DMBXT9J DMBXT9J DN PMID24915291C38 DMBXT9J MI TTN2I9E DMBXT9J MN Tyrosine-protein kinase BMX (BMX) DMBXT9J MT DTT DMBXT9J MA Inhibitor DMBXT9J RN Discovery of a series of 2,5-diaminopyrimidine covalent irreversible inhibitors of Bruton's tyrosine kinase with in vivo antitumor activity. J Med Chem. 2014 Jun 26;57(12):5112-28. DMBXT9J RU https://pubmed.ncbi.nlm.nih.gov/24915291 DMBXT9J DI DMBXT9J DMBXT9J DN PMID24915291C38 DMBXT9J MI TTGM6VW DMBXT9J MN Tyrosine-protein kinase BTK (ATK) DMBXT9J MT DTT DMBXT9J MA Inhibitor DMBXT9J RN Discovery of a series of 2,5-diaminopyrimidine covalent irreversible inhibitors of Bruton's tyrosine kinase with in vivo antitumor activity. J Med Chem. 2014 Jun 26;57(12):5112-28. DMBXT9J RU https://pubmed.ncbi.nlm.nih.gov/24915291 DMBXT9J DI DMBXT9J DMBXT9J DN PMID24915291C38 DMBXT9J MI TT1ZV49 DMBXT9J MN Tyrosine-protein kinase Tec (PSCTK4) DMBXT9J MT DTT DMBXT9J MA Inhibitor DMBXT9J RN Discovery of a series of 2,5-diaminopyrimidine covalent irreversible inhibitors of Bruton's tyrosine kinase with in vivo antitumor activity. J Med Chem. 2014 Jun 26;57(12):5112-28. DMBXT9J RU https://pubmed.ncbi.nlm.nih.gov/24915291 DMBXT9J DI DMBXT9J DMBXT9J DN PMID24915291C38 DMBXT9J MI TT8M1DP DMBXT9J MN Tyrosine-protein kinase TXK (TXK) DMBXT9J MT DTT DMBXT9J MA Inhibitor DMBXT9J RN Discovery of a series of 2,5-diaminopyrimidine covalent irreversible inhibitors of Bruton's tyrosine kinase with in vivo antitumor activity. J Med Chem. 2014 Jun 26;57(12):5112-28. DMBXT9J RU https://pubmed.ncbi.nlm.nih.gov/24915291 DMNPA2C DI DMNPA2C DMNPA2C DN PMID24946214C3b DMNPA2C MI TT68GPI DMNPA2C MN Proteasome beta-5 (PS beta-5) DMNPA2C MT DTT DMNPA2C MA Inhibitor DMNPA2C RN Optimization of peptidomimetic boronates bearing a P3 bicyclic scaffold as proteasome inhibitors. Eur J Med Chem. 2014 Aug 18;83:1-14. DMNPA2C RU https://pubmed.ncbi.nlm.nih.gov/24946214 DML0PFU DI DML0PFU DML0PFU DN PMID24997608CA DML0PFU MI TT08JVB DML0PFU MN G-protein coupled receptor 120 (GPR120) DML0PFU MT DTT DML0PFU MA Agonist DML0PFU RN A Gpr120-selective agonist improves insulin resistance and chronic inflammation in obese mice. Nat Med. 2014 Aug;20(8):942-7. DML0PFU RU https://pubmed.ncbi.nlm.nih.gov/24997608 DM5D3SN DI DM5D3SN DM5D3SN DN PMID24999562C6b DM5D3SN MI TT2L6C5 DM5D3SN MN Neuromedin-U receptor 2 (NMUR2) DM5D3SN MT DTT DM5D3SN MA Agonist DM5D3SN RN Discovery of selective hexapeptide agonists to human neuromedin U receptors types 1 and 2. J Med Chem. 2014 Aug 14;57(15):6583-93. DM5D3SN RU https://pubmed.ncbi.nlm.nih.gov/24999562 DMD7VOZ DI DMD7VOZ DMD7VOZ DN PMID24999562C8d DMD7VOZ MI TTI7T1Q DMD7VOZ MN Neuromedin-U receptor 1 (NMUR1) DMD7VOZ MT DTT DMD7VOZ MA Agonist DMD7VOZ RN Discovery of selective hexapeptide agonists to human neuromedin U receptors types 1 and 2. J Med Chem. 2014 Aug 14;57(15):6583-93. DMD7VOZ RU https://pubmed.ncbi.nlm.nih.gov/24999562 DMJPR8M DI DMJPR8M DMJPR8M DN PMID25037917C58 DMJPR8M MI TTVBI8W DMJPR8M MN Dopamine transporter (DAT) DMJPR8M MT DTT DMJPR8M MA Inhibitor DMJPR8M RN Novel inhibitors of the high-affinity L-proline transporter as potential therapeutic agents for the treatment of cognitive disorders. Bioorg Med Chem Lett. 2014 Aug 15;24(16):3886-90. DMJPR8M RU https://pubmed.ncbi.nlm.nih.gov/25037917 DMJPR8M DI DMJPR8M DMJPR8M DN PMID25037917C58 DMJPR8M MI TT9LGO5 DMJPR8M MN Sodium-dependent proline transporter (SLC6A7) DMJPR8M MT DTT DMJPR8M MA Inhibitor DMJPR8M RN Novel inhibitors of the high-affinity L-proline transporter as potential therapeutic agents for the treatment of cognitive disorders. Bioorg Med Chem Lett. 2014 Aug 15;24(16):3886-90. DMJPR8M RU https://pubmed.ncbi.nlm.nih.gov/25037917 DMRFQ1W DI DMRFQ1W DMRFQ1W DN PMID25050158C14 DMRFQ1W MI TTDCVZW DMRFQ1W MN Gamma-aminobutyric acid B receptor (GABBR) DMRFQ1W MT DTT DMRFQ1W MA Modulator (allosteric modulator) DMRFQ1W RN Discovery of a Negative Allosteric Modulator of GABAB Receptors. ACS Med Chem Lett. 2014 May 27;5(7):742-7. DMRFQ1W RU https://pubmed.ncbi.nlm.nih.gov/25050158 DMTCGLY DI DMTCGLY DMTCGLY DN PMID25259874C21 DMTCGLY MI TTI6B3F DMTCGLY MN C3a anaphylatoxin chemotactic receptor (C3AR1) DMTCGLY MT DTT DMTCGLY MA Agonist DMTCGLY RN Potent heterocyclic ligands for human complement c3a receptor. J Med Chem. 2014 Oct 23;57(20):8459-70. DMTCGLY RU https://pubmed.ncbi.nlm.nih.gov/25259874 DMZKEIH DI DMZKEIH DMZKEIH DN PMID25259874C4 DMZKEIH MI TTI6B3F DMZKEIH MN C3a anaphylatoxin chemotactic receptor (C3AR1) DMZKEIH MT DTT DMZKEIH MA Antagonist DMZKEIH RN Potent heterocyclic ligands for human complement c3a receptor. J Med Chem. 2014 Oct 23;57(20):8459-70. DMZKEIH RU https://pubmed.ncbi.nlm.nih.gov/25259874 DMDO9AJ DI DMDO9AJ DMDO9AJ DN PMID25313322C15 DMDO9AJ MI TTTPCNU DMDO9AJ MN G-protein coupled receptor 39 (GPR39) DMDO9AJ MT DTT DMDO9AJ MA Agonist DMDO9AJ RN Discovery of 2-Pyridylpyrimidines as the First Orally Bioavailable GPR39 Agonists. ACS Med Chem Lett. 2014 Aug 4;5(10):1114-8. DMDO9AJ RU https://pubmed.ncbi.nlm.nih.gov/25313322 DM5GL23 DI DM5GL23 DM5GL23 DN PMID25408830C1 DM5GL23 MI TTT46BN DM5GL23 MN Bromodomain and PHD finger containing 1 (BRPF1) DM5GL23 MT DTT DM5GL23 MA Inhibitor DM5GL23 RN 1,3-Dimethyl Benzimidazolones Are Potent, Selective Inhibitors of the BRPF1 Bromodomain. ACS Med Chem Lett. 2014 Sep 10;5(11):1190-5. DM5GL23 RU https://pubmed.ncbi.nlm.nih.gov/25408830 DM5GL23 DI DM5GL23 DM5GL23 DN PMID25408830C1 DM5GL23 MI TTRA6BO DM5GL23 MN Bromodomain-containing protein 4 (BRD4) DM5GL23 MT DTT DM5GL23 MA Inhibitor DM5GL23 RN 1,3-Dimethyl Benzimidazolones Are Potent, Selective Inhibitors of the BRPF1 Bromodomain. ACS Med Chem Lett. 2014 Sep 10;5(11):1190-5. DM5GL23 RU https://pubmed.ncbi.nlm.nih.gov/25408830 DM20E13 DI DM20E13 DM20E13 DN PMID25408830C2 DM20E13 MI TTT46BN DM20E13 MN Bromodomain and PHD finger containing 1 (BRPF1) DM20E13 MT DTT DM20E13 MA Inhibitor DM20E13 RN 1,3-Dimethyl Benzimidazolones Are Potent, Selective Inhibitors of the BRPF1 Bromodomain. ACS Med Chem Lett. 2014 Sep 10;5(11):1190-5. DM20E13 RU https://pubmed.ncbi.nlm.nih.gov/25408830 DM20E13 DI DM20E13 DM20E13 DN PMID25408830C2 DM20E13 MI TTRA6BO DM20E13 MN Bromodomain-containing protein 4 (BRD4) DM20E13 MT DTT DM20E13 MA Inhibitor DM20E13 RN 1,3-Dimethyl Benzimidazolones Are Potent, Selective Inhibitors of the BRPF1 Bromodomain. ACS Med Chem Lett. 2014 Sep 10;5(11):1190-5. DM20E13 RU https://pubmed.ncbi.nlm.nih.gov/25408830 DM8SBR2 DI DM8SBR2 DM8SBR2 DN PMID25408830C3 DM8SBR2 MI TTT46BN DM8SBR2 MN Bromodomain and PHD finger containing 1 (BRPF1) DM8SBR2 MT DTT DM8SBR2 MA Inhibitor DM8SBR2 RN 1,3-Dimethyl Benzimidazolones Are Potent, Selective Inhibitors of the BRPF1 Bromodomain. ACS Med Chem Lett. 2014 Sep 10;5(11):1190-5. DM8SBR2 RU https://pubmed.ncbi.nlm.nih.gov/25408830 DM8SBR2 DI DM8SBR2 DM8SBR2 DN PMID25408830C3 DM8SBR2 MI TTRA6BO DM8SBR2 MN Bromodomain-containing protein 4 (BRD4) DM8SBR2 MT DTT DM8SBR2 MA Inhibitor DM8SBR2 RN 1,3-Dimethyl Benzimidazolones Are Potent, Selective Inhibitors of the BRPF1 Bromodomain. ACS Med Chem Lett. 2014 Sep 10;5(11):1190-5. DM8SBR2 RU https://pubmed.ncbi.nlm.nih.gov/25408830 DMWZJT0 DI DMWZJT0 DMWZJT0 DN PMID25489658C4d DMWZJT0 MI TTDA81R DMWZJT0 MN Kallikrein-14 (KLK14) DMWZJT0 MT DTT DMWZJT0 MA Inhibitor DMWZJT0 RN Toward the first class of suicide inhibitors of kallikreins involved in skin diseases. J Med Chem. 2015 Jan 22;58(2):598-612. DMWZJT0 RU https://pubmed.ncbi.nlm.nih.gov/25489658 DMWZJT0 DI DMWZJT0 DMWZJT0 DN PMID25489658C4d DMWZJT0 MI TTULSEW DMWZJT0 MN Kallikrein-5 (KLK5) DMWZJT0 MT DTT DMWZJT0 MA Inhibitor DMWZJT0 RN Toward the first class of suicide inhibitors of kallikreins involved in skin diseases. J Med Chem. 2015 Jan 22;58(2):598-612. DMWZJT0 RU https://pubmed.ncbi.nlm.nih.gov/25489658 DMWZJT0 DI DMWZJT0 DMWZJT0 DN PMID25489658C4d DMWZJT0 MI TTE6GTB DMWZJT0 MN Kallikrein-7 (KLK7) DMWZJT0 MT DTT DMWZJT0 MA Inhibitor DMWZJT0 RN Toward the first class of suicide inhibitors of kallikreins involved in skin diseases. J Med Chem. 2015 Jan 22;58(2):598-612. DMWZJT0 RU https://pubmed.ncbi.nlm.nih.gov/25489658 DMWZJT0 DI DMWZJT0 DMWZJT0 DN PMID25489658C4d DMWZJT0 MI TTPRO7W DMWZJT0 MN Suppressor of tumorigenicity 14 protein (ST14) DMWZJT0 MT DTT DMWZJT0 MA Inhibitor DMWZJT0 RN Toward the first class of suicide inhibitors of kallikreins involved in skin diseases. J Med Chem. 2015 Jan 22;58(2):598-612. DMWZJT0 RU https://pubmed.ncbi.nlm.nih.gov/25489658 DMO6NEX DI DMO6NEX DMO6NEX DN PMID25497965C17c DMO6NEX MI TTHYDUM DMO6NEX MN Bombesin receptor (BS) DMO6NEX MT DTT DMO6NEX MA Agonist DMO6NEX RN Synthesis and biological evaluation of novel chiral diazepine derivatives as bombesin receptor subtype-3 (BRS-3) agonists incorporating an antedrug approach. Bioorg Med Chem. 2015 Jan 1;23(1):89-104. DMO6NEX RU https://pubmed.ncbi.nlm.nih.gov/25497965 DM4PZ37 DI DM4PZ37 DM4PZ37 DN PMID25703523C7d DM4PZ37 MI TTRA6BO DM4PZ37 MN Bromodomain-containing protein 4 (BRD4) DM4PZ37 MT DTT DM4PZ37 MA Inhibitor DM4PZ37 RN 9H-purine scaffold reveals induced-fit pocket plasticity of the BRD9 bromodomain. J Med Chem. 2015 Mar 26;58(6):2718-36. DM4PZ37 RU https://pubmed.ncbi.nlm.nih.gov/25703523 DM7AJER DI DM7AJER DM7AJER DN PMID25719566C1 DM7AJER MI TT6K8YG DM7AJER MN Bromodomain adjacent to zinc finger 2B (BAZ2B) DM7AJER MT DTT DM7AJER MA Inhibitor DM7AJER RN Structure enabled design of BAZ2-ICR, a chemical probe targeting the bromodomains of BAZ2A and BAZ2B. J Med Chem. 2015 Mar 12;58(5):2553-9. DM7AJER RU https://pubmed.ncbi.nlm.nih.gov/25719566 DMGCAIO DI DMGCAIO DMGCAIO DN PMID25719566C7 DMGCAIO MI TT6K8YG DMGCAIO MN Bromodomain adjacent to zinc finger 2B (BAZ2B) DMGCAIO MT DTT DMGCAIO MA Inhibitor DMGCAIO RN Structure enabled design of BAZ2-ICR, a chemical probe targeting the bromodomains of BAZ2A and BAZ2B. J Med Chem. 2015 Mar 12;58(5):2553-9. DMGCAIO RU https://pubmed.ncbi.nlm.nih.gov/25719566 DMDYT6P DI DMDYT6P DMDYT6P DN PMID25742366C14b DMDYT6P MI TTSCHFW DMDYT6P MN Peptidyl arginine deiminase type III (PADI3) DMDYT6P MT DTT DMDYT6P MA Inhibitor DMDYT6P RN Identification of multiple structurally distinct, nonpeptidic small molecule inhibitors of protein arginine deiminase 3 using a substrate-based fragment method. J Am Chem Soc. 2015 Mar 18;137(10):3616-21. DMDYT6P RU https://pubmed.ncbi.nlm.nih.gov/25742366 DMDYT6P DI DMDYT6P DMDYT6P DN PMID25742366C14b DMDYT6P MI TTQHAXM DMDYT6P MN Peptidyl arginine deiminase type IV (PADI4) DMDYT6P MT DTT DMDYT6P MA Inhibitor DMDYT6P RN Identification of multiple structurally distinct, nonpeptidic small molecule inhibitors of protein arginine deiminase 3 using a substrate-based fragment method. J Am Chem Soc. 2015 Mar 18;137(10):3616-21. DMDYT6P RU https://pubmed.ncbi.nlm.nih.gov/25742366 DMUEDBP DI DMUEDBP DMUEDBP DN PMID25815140C48 DMUEDBP MI TTVP9IQ DMUEDBP MN Solute carrier family 28 member 2 (SLC28A2) DMUEDBP MT DTT DMUEDBP MA Inhibitor DMUEDBP RN Identification of 8-aminoadenosine derivatives as a new class of human concentrative nucleoside transporter 2 inhibitors. ACS Med Chem Lett. 2015 Jan 28;6(3):244-8. DMUEDBP RU https://pubmed.ncbi.nlm.nih.gov/25815140 DMGWZA3 DI DMGWZA3 DMGWZA3 DN PMID25974391C34 DMGWZA3 MI TTT46BN DMGWZA3 MN Bromodomain and PHD finger containing 1 (BRPF1) DMGWZA3 MT DTT DMGWZA3 MA Inhibitor DMGWZA3 RN Discovery of a Chemical Tool Inhibitor Targeting the Bromodomains of TRIM24 and BRPF. J Med Chem. 2016 Feb 25;59(4):1642-7. DMGWZA3 RU https://pubmed.ncbi.nlm.nih.gov/25974391 DMGWZA3 DI DMGWZA3 DMGWZA3 DN PMID25974391C34 DMGWZA3 MI TT9Q7AE DMGWZA3 MN Tripartite motif-containing 24 (TRIM24) DMGWZA3 MT DTT DMGWZA3 MA Inhibitor DMGWZA3 RN Discovery of a Chemical Tool Inhibitor Targeting the Bromodomains of TRIM24 and BRPF. J Med Chem. 2016 Feb 25;59(4):1642-7. DMGWZA3 RU https://pubmed.ncbi.nlm.nih.gov/25974391 DMHZOIU DI DMHZOIU DMHZOIU DN PMID26061392C2 DMHZOIU MI TT0EOB8 DMHZOIU MN B-Raf messenger RNA (BRAF mRNA) DMHZOIU MT DTT DMHZOIU MA Inhibitor DMHZOIU RN Photoactivatable Prodrugs of Antimelanoma Agent Vemurafenib. ACS Chem Biol. 2015 Sep 18;10(9):2099-107. DMHZOIU RU https://pubmed.ncbi.nlm.nih.gov/26061392 DM8D6ZL DI DM8D6ZL DM8D6ZL DN PMID26080733C7r DM8D6ZL MI TTRLW2X DM8D6ZL MN Fibroblast growth factor receptor 1 (FGFR1) DM8D6ZL MT DTT DM8D6ZL MA Inhibitor DM8D6ZL RN Design, synthesis and biological evaluation of novel FGFR inhibitors bearing an indazole scaffold. Org Biomol Chem. 2015 Jul 28;13(28):7643-54. DM8D6ZL RU https://pubmed.ncbi.nlm.nih.gov/26080733 DM4TN73 DI DM4TN73 DM4TN73 DN PMID26155854C57 DM4TN73 MI TT9A0HI DM4TN73 MN ATPase family AAA domain containing 2 (ATAD2) DM4TN73 MT DTT DM4TN73 MA Inhibitor DM4TN73 RN Fragment-Based Discovery of Low-Micromolar ATAD2 Bromodomain Inhibitors. J Med Chem. 2015 Jul 23;58(14):5649-73. DM4TN73 RU https://pubmed.ncbi.nlm.nih.gov/26155854 DMM5SI4 DI DMM5SI4 DMM5SI4 DN PMID26155854C60 DMM5SI4 MI TT9A0HI DMM5SI4 MN ATPase family AAA domain containing 2 (ATAD2) DMM5SI4 MT DTT DMM5SI4 MA Inhibitor DMM5SI4 RN Fragment-Based Discovery of Low-Micromolar ATAD2 Bromodomain Inhibitors. J Med Chem. 2015 Jul 23;58(14):5649-73. DMM5SI4 RU https://pubmed.ncbi.nlm.nih.gov/26155854 DMTO95J DI DMTO95J DMTO95J DN PMID26161824C70 DMTO95J MI TT6OEDT DMTO95J MN Cannabinoid receptor 1 (CB1) DMTO95J MT DTT DMTO95J MA Antagonist DMTO95J RN A comprehensive patents review on cannabinoid 1 receptor antagonists as antiobesity agents. Expert Opin Ther Pat. 2015 Oct;25(10):1093-116. DMTO95J RU https://pubmed.ncbi.nlm.nih.gov/26161824 DM9J5Q7 DI DM9J5Q7 DM9J5Q7 DN PMID2909732C7 DM9J5Q7 MI TTPADOQ DM9J5Q7 MN HMG-CoA reductase (HMGCR) DM9J5Q7 MT DTT DM9J5Q7 MA Inhibitor DM9J5Q7 RN Synthesis and biological evaluation of a monocyclic, fully functional analogue of compactin. J Med Chem. 1989 Jan;32(1):197-202. DM9J5Q7 RU https://pubmed.ncbi.nlm.nih.gov/2909732 DMOA1Y7 DI DMOA1Y7 DMOA1Y7 DN PMID30247903-Compound-General structure10 DMOA1Y7 MI TT8ZLTI DMOA1Y7 MN Programmed cell death 1 ligand 1 (PD-L1) DMOA1Y7 MT DTT DMOA1Y7 MA Inhibitor DMOA1Y7 RN Development of Inhibitors of the Programmed Cell Death-1/Programmed Cell Death-Ligand 1 Signaling Pathway.J Med Chem. 2019 Feb 28;62(4):1715-1730. DMOA1Y7 RU https://pubmed.ncbi.nlm.nih.gov/30247903 DMA3ZPH DI DMA3ZPH DMA3ZPH DN PMID30247903-Compound-General structure12 DMA3ZPH MI TT8ZLTI DMA3ZPH MN Programmed cell death 1 ligand 1 (PD-L1) DMA3ZPH MT DTT DMA3ZPH MA Inhibitor DMA3ZPH RN Development of Inhibitors of the Programmed Cell Death-1/Programmed Cell Death-Ligand 1 Signaling Pathway.J Med Chem. 2019 Feb 28;62(4):1715-1730. DMA3ZPH RU https://pubmed.ncbi.nlm.nih.gov/30247903 DMJ0YZA DI DMJ0YZA DMJ0YZA DN PMID30247903-Compound-General structure13 DMJ0YZA MI TTNBFWK DMJ0YZA MN Programmed cell death protein 1 (PD-1) DMJ0YZA MT DTT DMJ0YZA MA antagonist DMJ0YZA RN Development of Inhibitors of the Programmed Cell Death-1/Programmed Cell Death-Ligand 1 Signaling Pathway.J Med Chem. 2019 Feb 28;62(4):1715-1730. DMJ0YZA RU https://pubmed.ncbi.nlm.nih.gov/30247903 DM5Z4JR DI DM5Z4JR DM5Z4JR DN PMID30247903-Compound-General structure14 DM5Z4JR MI TTNBFWK DM5Z4JR MN Programmed cell death protein 1 (PD-1) DM5Z4JR MT DTT DM5Z4JR MA antagonist DM5Z4JR RN Development of Inhibitors of the Programmed Cell Death-1/Programmed Cell Death-Ligand 1 Signaling Pathway.J Med Chem. 2019 Feb 28;62(4):1715-1730. DM5Z4JR RU https://pubmed.ncbi.nlm.nih.gov/30247903 DMCJDLO DI DMCJDLO DMCJDLO DN PMID30247903-Compound-General structure15 DMCJDLO MI TTNBFWK DMCJDLO MN Programmed cell death protein 1 (PD-1) DMCJDLO MT DTT DMCJDLO MA antagonist DMCJDLO RN Development of Inhibitors of the Programmed Cell Death-1/Programmed Cell Death-Ligand 1 Signaling Pathway.J Med Chem. 2019 Feb 28;62(4):1715-1730. DMCJDLO RU https://pubmed.ncbi.nlm.nih.gov/30247903 DMVR4QH DI DMVR4QH DMVR4QH DN PMID30247903-Compound-General structure16 DMVR4QH MI TTNBFWK DMVR4QH MN Programmed cell death protein 1 (PD-1) DMVR4QH MT DTT DMVR4QH MA Inhibitor DMVR4QH RN Development of Inhibitors of the Programmed Cell Death-1/Programmed Cell Death-Ligand 1 Signaling Pathway.J Med Chem. 2019 Feb 28;62(4):1715-1730. DMVR4QH RU https://pubmed.ncbi.nlm.nih.gov/30247903 DMC3GFI DI DMC3GFI DMC3GFI DN PMID30247903-Compound-General structure17 DMC3GFI MI TTNBFWK DMC3GFI MN Programmed cell death protein 1 (PD-1) DMC3GFI MT DTT DMC3GFI MA Inhibitor DMC3GFI RN Development of Inhibitors of the Programmed Cell Death-1/Programmed Cell Death-Ligand 1 Signaling Pathway.J Med Chem. 2019 Feb 28;62(4):1715-1730. DMC3GFI RU https://pubmed.ncbi.nlm.nih.gov/30247903 DMZBQ5R DI DMZBQ5R DMZBQ5R DN PMID30247903-Compound-General structure18 DMZBQ5R MI TT23XQV DMZBQ5R MN PD-1-PD-L1 interaction (PD-1/PD-L1 PPI) DMZBQ5R MT DTT DMZBQ5R MA Inhibitor DMZBQ5R RN Development of Inhibitors of the Programmed Cell Death-1/Programmed Cell Death-Ligand 1 Signaling Pathway.J Med Chem. 2019 Feb 28;62(4):1715-1730. DMZBQ5R RU https://pubmed.ncbi.nlm.nih.gov/30247903 DM8LS3I DI DM8LS3I DM8LS3I DN PMID30247903-Compound-General structure19 DM8LS3I MI TT23XQV DM8LS3I MN PD-1-PD-L1 interaction (PD-1/PD-L1 PPI) DM8LS3I MT DTT DM8LS3I MA Inhibitor DM8LS3I RN Development of Inhibitors of the Programmed Cell Death-1/Programmed Cell Death-Ligand 1 Signaling Pathway.J Med Chem. 2019 Feb 28;62(4):1715-1730. DM8LS3I RU https://pubmed.ncbi.nlm.nih.gov/30247903 DMCNXKE DI DMCNXKE DMCNXKE DN PMID30247903-Compound-General structure20 DMCNXKE MI TTNBFWK DMCNXKE MN Programmed cell death protein 1 (PD-1) DMCNXKE MT DTT DMCNXKE MA Inhibitor DMCNXKE RN Development of Inhibitors of the Programmed Cell Death-1/Programmed Cell Death-Ligand 1 Signaling Pathway.J Med Chem. 2019 Feb 28;62(4):1715-1730. DMCNXKE RU https://pubmed.ncbi.nlm.nih.gov/30247903 DMFACRH DI DMFACRH DMFACRH DN PMID30247903-Compound-General structure21 DMFACRH MI TTNBFWK DMFACRH MN Programmed cell death protein 1 (PD-1) DMFACRH MT DTT DMFACRH MA Inhibitor DMFACRH RN Development of Inhibitors of the Programmed Cell Death-1/Programmed Cell Death-Ligand 1 Signaling Pathway.J Med Chem. 2019 Feb 28;62(4):1715-1730. DMFACRH RU https://pubmed.ncbi.nlm.nih.gov/30247903 DMLD1IU DI DMLD1IU DMLD1IU DN PMID30247903-Compound-General structure22 DMLD1IU MI TTNBFWK DMLD1IU MN Programmed cell death protein 1 (PD-1) DMLD1IU MT DTT DMLD1IU MA Inhibitor DMLD1IU RN Development of Inhibitors of the Programmed Cell Death-1/Programmed Cell Death-Ligand 1 Signaling Pathway.J Med Chem. 2019 Feb 28;62(4):1715-1730. DMLD1IU RU https://pubmed.ncbi.nlm.nih.gov/30247903 DMMXLHW DI DMMXLHW DMMXLHW DN PMID30247903-Compound-General structure23 DMMXLHW MI TTNBFWK DMMXLHW MN Programmed cell death protein 1 (PD-1) DMMXLHW MT DTT DMMXLHW MA Inhibitor DMMXLHW RN Development of Inhibitors of the Programmed Cell Death-1/Programmed Cell Death-Ligand 1 Signaling Pathway.J Med Chem. 2019 Feb 28;62(4):1715-1730. DMMXLHW RU https://pubmed.ncbi.nlm.nih.gov/30247903 DM8CPZB DI DM8CPZB DM8CPZB DN PMID30247903-Compound-General structure24 DM8CPZB MI TTNBFWK DM8CPZB MN Programmed cell death protein 1 (PD-1) DM8CPZB MT DTT DM8CPZB MA Inhibitor DM8CPZB RN Development of Inhibitors of the Programmed Cell Death-1/Programmed Cell Death-Ligand 1 Signaling Pathway.J Med Chem. 2019 Feb 28;62(4):1715-1730. DM8CPZB RU https://pubmed.ncbi.nlm.nih.gov/30247903 DMEMLHR DI DMEMLHR DMEMLHR DN PMID30247903-Compound-General structure25 DMEMLHR MI TTNBFWK DMEMLHR MN Programmed cell death protein 1 (PD-1) DMEMLHR MT DTT DMEMLHR MA Inhibitor DMEMLHR RN Development of Inhibitors of the Programmed Cell Death-1/Programmed Cell Death-Ligand 1 Signaling Pathway.J Med Chem. 2019 Feb 28;62(4):1715-1730. DMEMLHR RU https://pubmed.ncbi.nlm.nih.gov/30247903 DM4BF1P DI DM4BF1P DM4BF1P DN PMID30247903-Compound-General structure26 DM4BF1P MI TT23XQV DM4BF1P MN PD-1-PD-L1 interaction (PD-1/PD-L1 PPI) DM4BF1P MT DTT DM4BF1P MA Inhibitor DM4BF1P RN Development of Inhibitors of the Programmed Cell Death-1/Programmed Cell Death-Ligand 1 Signaling Pathway.J Med Chem. 2019 Feb 28;62(4):1715-1730. DM4BF1P RU https://pubmed.ncbi.nlm.nih.gov/30247903 DMYSWO4 DI DMYSWO4 DMYSWO4 DN PMID30247903-Compound-General structure27 DMYSWO4 MI TT23XQV DMYSWO4 MN PD-1-PD-L1 interaction (PD-1/PD-L1 PPI) DMYSWO4 MT DTT DMYSWO4 MA Inhibitor DMYSWO4 RN Development of Inhibitors of the Programmed Cell Death-1/Programmed Cell Death-Ligand 1 Signaling Pathway.J Med Chem. 2019 Feb 28;62(4):1715-1730. DMYSWO4 RU https://pubmed.ncbi.nlm.nih.gov/30247903 DMALSIW DI DMALSIW DMALSIW DN PMID30247903-Compound-General structure28 DMALSIW MI TT23XQV DMALSIW MN PD-1-PD-L1 interaction (PD-1/PD-L1 PPI) DMALSIW MT DTT DMALSIW MA Inhibitor DMALSIW RN Development of Inhibitors of the Programmed Cell Death-1/Programmed Cell Death-Ligand 1 Signaling Pathway.J Med Chem. 2019 Feb 28;62(4):1715-1730. DMALSIW RU https://pubmed.ncbi.nlm.nih.gov/30247903 DM9FEB6 DI DM9FEB6 DM9FEB6 DN PMID30247903-Compound-General structure29 DM9FEB6 MI TT23XQV DM9FEB6 MN PD-1-PD-L1 interaction (PD-1/PD-L1 PPI) DM9FEB6 MT DTT DM9FEB6 MA Inhibitor DM9FEB6 RN Development of Inhibitors of the Programmed Cell Death-1/Programmed Cell Death-Ligand 1 Signaling Pathway.J Med Chem. 2019 Feb 28;62(4):1715-1730. DM9FEB6 RU https://pubmed.ncbi.nlm.nih.gov/30247903 DMHQ1ZD DI DMHQ1ZD DMHQ1ZD DN PMID30247903-Compound-General structure30 DMHQ1ZD MI TT23XQV DMHQ1ZD MN PD-1-PD-L1 interaction (PD-1/PD-L1 PPI) DMHQ1ZD MT DTT DMHQ1ZD MA Inhibitor DMHQ1ZD RN Development of Inhibitors of the Programmed Cell Death-1/Programmed Cell Death-Ligand 1 Signaling Pathway.J Med Chem. 2019 Feb 28;62(4):1715-1730. DMHQ1ZD RU https://pubmed.ncbi.nlm.nih.gov/30247903 DMSLWBI DI DMSLWBI DMSLWBI DN PMID30247903-Compound-General structure31 DMSLWBI MI TT23XQV DMSLWBI MN PD-1-PD-L1 interaction (PD-1/PD-L1 PPI) DMSLWBI MT DTT DMSLWBI MA Inhibitor DMSLWBI RN Development of Inhibitors of the Programmed Cell Death-1/Programmed Cell Death-Ligand 1 Signaling Pathway.J Med Chem. 2019 Feb 28;62(4):1715-1730. DMSLWBI RU https://pubmed.ncbi.nlm.nih.gov/30247903 DMD04TR DI DMD04TR DMD04TR DN PMID30247903-Compound-General structure32 DMD04TR MI TT23XQV DMD04TR MN PD-1-PD-L1 interaction (PD-1/PD-L1 PPI) DMD04TR MT DTT DMD04TR MA Inhibitor DMD04TR RN Development of Inhibitors of the Programmed Cell Death-1/Programmed Cell Death-Ligand 1 Signaling Pathway.J Med Chem. 2019 Feb 28;62(4):1715-1730. DMD04TR RU https://pubmed.ncbi.nlm.nih.gov/30247903 DMFLQ96 DI DMFLQ96 DMFLQ96 DN PMID30247903-Compound-General structure33 DMFLQ96 MI TT23XQV DMFLQ96 MN PD-1-PD-L1 interaction (PD-1/PD-L1 PPI) DMFLQ96 MT DTT DMFLQ96 MA Inhibitor DMFLQ96 RN Development of Inhibitors of the Programmed Cell Death-1/Programmed Cell Death-Ligand 1 Signaling Pathway.J Med Chem. 2019 Feb 28;62(4):1715-1730. DMFLQ96 RU https://pubmed.ncbi.nlm.nih.gov/30247903 DM1YOVG DI DM1YOVG DM1YOVG DN PMID30247903-Compound-General structure34 DM1YOVG MI TT23XQV DM1YOVG MN PD-1-PD-L1 interaction (PD-1/PD-L1 PPI) DM1YOVG MT DTT DM1YOVG MA Inhibitor DM1YOVG RN Development of Inhibitors of the Programmed Cell Death-1/Programmed Cell Death-Ligand 1 Signaling Pathway.J Med Chem. 2019 Feb 28;62(4):1715-1730. DM1YOVG RU https://pubmed.ncbi.nlm.nih.gov/30247903 DMF9HIJ DI DMF9HIJ DMF9HIJ DN PMID30247903-Compound-General structure35 DMF9HIJ MI TT23XQV DMF9HIJ MN PD-1-PD-L1 interaction (PD-1/PD-L1 PPI) DMF9HIJ MT DTT DMF9HIJ MA Inhibitor DMF9HIJ RN Development of Inhibitors of the Programmed Cell Death-1/Programmed Cell Death-Ligand 1 Signaling Pathway.J Med Chem. 2019 Feb 28;62(4):1715-1730. DMF9HIJ RU https://pubmed.ncbi.nlm.nih.gov/30247903 DMI4EU5 DI DMI4EU5 DMI4EU5 DN PMID30247903-Compound-General structure36 DMI4EU5 MI TT23XQV DMI4EU5 MN PD-1-PD-L1 interaction (PD-1/PD-L1 PPI) DMI4EU5 MT DTT DMI4EU5 MA Inhibitor DMI4EU5 RN Development of Inhibitors of the Programmed Cell Death-1/Programmed Cell Death-Ligand 1 Signaling Pathway.J Med Chem. 2019 Feb 28;62(4):1715-1730. DMI4EU5 RU https://pubmed.ncbi.nlm.nih.gov/30247903 DMDWHIN DI DMDWHIN DMDWHIN DN PMID30247903-Compound-General structure37 DMDWHIN MI TT23XQV DMDWHIN MN PD-1-PD-L1 interaction (PD-1/PD-L1 PPI) DMDWHIN MT DTT DMDWHIN MA Inhibitor DMDWHIN RN Development of Inhibitors of the Programmed Cell Death-1/Programmed Cell Death-Ligand 1 Signaling Pathway.J Med Chem. 2019 Feb 28;62(4):1715-1730. DMDWHIN RU https://pubmed.ncbi.nlm.nih.gov/30247903 DMDB9FT DI DMDB9FT DMDB9FT DN PMID30247903-Compound-General structure38 DMDB9FT MI TT23XQV DMDB9FT MN PD-1-PD-L1 interaction (PD-1/PD-L1 PPI) DMDB9FT MT DTT DMDB9FT MA Inhibitor DMDB9FT RN Development of Inhibitors of the Programmed Cell Death-1/Programmed Cell Death-Ligand 1 Signaling Pathway.J Med Chem. 2019 Feb 28;62(4):1715-1730. DMDB9FT RU https://pubmed.ncbi.nlm.nih.gov/30247903 DMKLATO DI DMKLATO DMKLATO DN PMID30247903-Compound-General structure39 DMKLATO MI TT23XQV DMKLATO MN PD-1-PD-L1 interaction (PD-1/PD-L1 PPI) DMKLATO MT DTT DMKLATO MA Inhibitor DMKLATO RN Development of Inhibitors of the Programmed Cell Death-1/Programmed Cell Death-Ligand 1 Signaling Pathway.J Med Chem. 2019 Feb 28;62(4):1715-1730. DMKLATO RU https://pubmed.ncbi.nlm.nih.gov/30247903 DMPZ3AY DI DMPZ3AY DMPZ3AY DN PMID30247903-Compound-General structure40 DMPZ3AY MI TT23XQV DMPZ3AY MN PD-1-PD-L1 interaction (PD-1/PD-L1 PPI) DMPZ3AY MT DTT DMPZ3AY MA Inhibitor DMPZ3AY RN Development of Inhibitors of the Programmed Cell Death-1/Programmed Cell Death-Ligand 1 Signaling Pathway.J Med Chem. 2019 Feb 28;62(4):1715-1730. DMPZ3AY RU https://pubmed.ncbi.nlm.nih.gov/30247903 DM0UMSF DI DM0UMSF DM0UMSF DN PMID30247903-Compound-General structure41 DM0UMSF MI TT23XQV DM0UMSF MN PD-1-PD-L1 interaction (PD-1/PD-L1 PPI) DM0UMSF MT DTT DM0UMSF MA Inhibitor DM0UMSF RN Development of Inhibitors of the Programmed Cell Death-1/Programmed Cell Death-Ligand 1 Signaling Pathway.J Med Chem. 2019 Feb 28;62(4):1715-1730. DM0UMSF RU https://pubmed.ncbi.nlm.nih.gov/30247903 DMRNF96 DI DMRNF96 DMRNF96 DN PMID30247903-Compound-General structure42 DMRNF96 MI TT23XQV DMRNF96 MN PD-1-PD-L1 interaction (PD-1/PD-L1 PPI) DMRNF96 MT DTT DMRNF96 MA Inhibitor DMRNF96 RN Development of Inhibitors of the Programmed Cell Death-1/Programmed Cell Death-Ligand 1 Signaling Pathway.J Med Chem. 2019 Feb 28;62(4):1715-1730. DMRNF96 RU https://pubmed.ncbi.nlm.nih.gov/30247903 DMY971M DI DMY971M DMY971M DN PMID30247903-Compound-General structure43 DMY971M MI TT23XQV DMY971M MN PD-1-PD-L1 interaction (PD-1/PD-L1 PPI) DMY971M MT DTT DMY971M MA Inhibitor DMY971M RN Development of Inhibitors of the Programmed Cell Death-1/Programmed Cell Death-Ligand 1 Signaling Pathway.J Med Chem. 2019 Feb 28;62(4):1715-1730. DMY971M RU https://pubmed.ncbi.nlm.nih.gov/30247903 DMRAFSB DI DMRAFSB DMRAFSB DN PMID30247903-Compound-General structure44 DMRAFSB MI TT23XQV DMRAFSB MN PD-1-PD-L1 interaction (PD-1/PD-L1 PPI) DMRAFSB MT DTT DMRAFSB MA Inhibitor DMRAFSB RN Development of Inhibitors of the Programmed Cell Death-1/Programmed Cell Death-Ligand 1 Signaling Pathway.J Med Chem. 2019 Feb 28;62(4):1715-1730. DMRAFSB RU https://pubmed.ncbi.nlm.nih.gov/30247903 DMHMUNB DI DMHMUNB DMHMUNB DN PMID30247903-Compound-General structure45 DMHMUNB MI TT23XQV DMHMUNB MN PD-1-PD-L1 interaction (PD-1/PD-L1 PPI) DMHMUNB MT DTT DMHMUNB MA Inhibitor DMHMUNB RN Development of Inhibitors of the Programmed Cell Death-1/Programmed Cell Death-Ligand 1 Signaling Pathway.J Med Chem. 2019 Feb 28;62(4):1715-1730. DMHMUNB RU https://pubmed.ncbi.nlm.nih.gov/30247903 DMWYCOB DI DMWYCOB DMWYCOB DN PMID30247903-Compound-General structure46 DMWYCOB MI TT23XQV DMWYCOB MN PD-1-PD-L1 interaction (PD-1/PD-L1 PPI) DMWYCOB MT DTT DMWYCOB MA Inhibitor DMWYCOB RN Development of Inhibitors of the Programmed Cell Death-1/Programmed Cell Death-Ligand 1 Signaling Pathway.J Med Chem. 2019 Feb 28;62(4):1715-1730. DMWYCOB RU https://pubmed.ncbi.nlm.nih.gov/30247903 DM7LUI2 DI DM7LUI2 DM7LUI2 DN PMID30247903-Compound-General structure5 DM7LUI2 MI TT8ZLTI DM7LUI2 MN Programmed cell death 1 ligand 1 (PD-L1) DM7LUI2 MT DTT DM7LUI2 MA Inhibitor DM7LUI2 RN Development of Inhibitors of the Programmed Cell Death-1/Programmed Cell Death-Ligand 1 Signaling Pathway.J Med Chem. 2019 Feb 28;62(4):1715-1730. DM7LUI2 RU https://pubmed.ncbi.nlm.nih.gov/30247903 DMHQ6C3 DI DMHQ6C3 DMHQ6C3 DN PMID30247903-Compound-General structure6 DMHQ6C3 MI TT8ZLTI DMHQ6C3 MN Programmed cell death 1 ligand 1 (PD-L1) DMHQ6C3 MT DTT DMHQ6C3 MA Inhibitor DMHQ6C3 RN Development of Inhibitors of the Programmed Cell Death-1/Programmed Cell Death-Ligand 1 Signaling Pathway.J Med Chem. 2019 Feb 28;62(4):1715-1730. DMHQ6C3 RU https://pubmed.ncbi.nlm.nih.gov/30247903 DM9QMA2 DI DM9QMA2 DM9QMA2 DN PMID30247903-Compound-General structure7 DM9QMA2 MI TT8ZLTI DM9QMA2 MN Programmed cell death 1 ligand 1 (PD-L1) DM9QMA2 MT DTT DM9QMA2 MA Inhibitor DM9QMA2 RN Development of Inhibitors of the Programmed Cell Death-1/Programmed Cell Death-Ligand 1 Signaling Pathway.J Med Chem. 2019 Feb 28;62(4):1715-1730. DM9QMA2 RU https://pubmed.ncbi.nlm.nih.gov/30247903 DMLMYE0 DI DMLMYE0 DMLMYE0 DN PMID30247903-Compound-General structure8 DMLMYE0 MI TT8ZLTI DMLMYE0 MN Programmed cell death 1 ligand 1 (PD-L1) DMLMYE0 MT DTT DMLMYE0 MA Inhibitor DMLMYE0 RN Development of Inhibitors of the Programmed Cell Death-1/Programmed Cell Death-Ligand 1 Signaling Pathway.J Med Chem. 2019 Feb 28;62(4):1715-1730. DMLMYE0 RU https://pubmed.ncbi.nlm.nih.gov/30247903 DMBR7A6 DI DMBR7A6 DMBR7A6 DN PMID30247903-Compound-General structure9 DMBR7A6 MI TT8ZLTI DMBR7A6 MN Programmed cell death 1 ligand 1 (PD-L1) DMBR7A6 MT DTT DMBR7A6 MA Inhibitor DMBR7A6 RN Development of Inhibitors of the Programmed Cell Death-1/Programmed Cell Death-Ligand 1 Signaling Pathway.J Med Chem. 2019 Feb 28;62(4):1715-1730. DMBR7A6 RU https://pubmed.ncbi.nlm.nih.gov/30247903 DMN39V6 DI DMN39V6 DMN39V6 DN PMID32321856-compound-11a DMN39V6 MI TTNHMO8 DMN39V6 MN COVID-19 papain-like proteinase (PL-PRO) DMN39V6 MT DTT DMN39V6 MA Inhibitor DMN39V6 RN Structure-based Design of Antiviral Drug Candidates Targeting the SARS-CoV-2 Main Protease. Science. 2020 Apr 22;eabb4489. DMN39V6 RU https://pubmed.ncbi.nlm.nih.gov/32321856 DM31QEY DI DM31QEY DM31QEY DN PMID32321856-compound-11b DM31QEY MI TTNHMO8 DM31QEY MN COVID-19 papain-like proteinase (PL-PRO) DM31QEY MT DTT DM31QEY MA Inhibitor DM31QEY RN Structure-based Design of Antiviral Drug Candidates Targeting the SARS-CoV-2 Main Protease. Science. 2020 Apr 22;eabb4489. DM31QEY RU https://pubmed.ncbi.nlm.nih.gov/32321856 DM3J746 DI DM3J746 DM3J746 DN PMID3514912C9 DM3J746 MI TTAHE2N DM3J746 MN Acrosin (ACR) DM3J746 MT DTT DM3J746 MA Inhibitor DM3J746 RN Synthesis and inhibition of human acrosin and trypsin and acute toxicity of aryl 4-guanidinobenzoates. J Med Chem. 1986 Apr;29(4):514-9. DM3J746 RU https://pubmed.ncbi.nlm.nih.gov/3514912 DM3J746 DI DM3J746 DM3J746 DN PMID3514912C9 DM3J746 MI TT2WR1T DM3J746 MN Cationic trypsinogen (PRSS1) DM3J746 MT DTT DM3J746 MA Inhibitor DM3J746 RN Synthesis and inhibition of human acrosin and trypsin and acute toxicity of aryl 4-guanidinobenzoates. J Med Chem. 1986 Apr;29(4):514-9. DM3J746 RU https://pubmed.ncbi.nlm.nih.gov/3514912 DM6ZOW4 DI DM6ZOW4 DM6ZOW4 DN PMID3941405C3d DM6ZOW4 MI TT4H0V2 DM6ZOW4 MN Dipeptidyl peptidase I (CTSC) DM6ZOW4 MT DTT DM6ZOW4 MA Inhibitor DM6ZOW4 RN Carboxyl-modified amino acids and peptides as protease inhibitors. J Med Chem. 1986 Jan;29(1):104-11. DM6ZOW4 RU https://pubmed.ncbi.nlm.nih.gov/3941405 DMB2MQW DI DMB2MQW DMB2MQW DN PMID7473541C11 DMB2MQW MI TTFQEO5 DMB2MQW MN Squalene synthetase (FDFT1) DMB2MQW MT DTT DMB2MQW MA Inhibitor DMB2MQW RN Phenoxypropylamines: a new series of squalene synthase inhibitors. J Med Chem. 1995 Oct 13;38(21):4157-60. DMB2MQW RU https://pubmed.ncbi.nlm.nih.gov/7473541 DM2CP5J DI DM2CP5J DM2CP5J DN PMID7473541C19 DM2CP5J MI TTFQEO5 DM2CP5J MN Squalene synthetase (FDFT1) DM2CP5J MT DTT DM2CP5J MA Inhibitor DM2CP5J RN Phenoxypropylamines: a new series of squalene synthase inhibitors. J Med Chem. 1995 Oct 13;38(21):4157-60. DM2CP5J RU https://pubmed.ncbi.nlm.nih.gov/7473541 DMMZ1LR DI DMMZ1LR DMMZ1LR DN PMID7473541C20 DMMZ1LR MI TTFQEO5 DMMZ1LR MN Squalene synthetase (FDFT1) DMMZ1LR MT DTT DMMZ1LR MA Inhibitor DMMZ1LR RN Phenoxypropylamines: a new series of squalene synthase inhibitors. J Med Chem. 1995 Oct 13;38(21):4157-60. DMMZ1LR RU https://pubmed.ncbi.nlm.nih.gov/7473541 DMMRSZB DI DMMRSZB DMMRSZB DN PMID7473541C21 DMMRSZB MI TTFQEO5 DMMRSZB MN Squalene synthetase (FDFT1) DMMRSZB MT DTT DMMRSZB MA Inhibitor DMMRSZB RN Phenoxypropylamines: a new series of squalene synthase inhibitors. J Med Chem. 1995 Oct 13;38(21):4157-60. DMMRSZB RU https://pubmed.ncbi.nlm.nih.gov/7473541 DMOJ57D DI DMOJ57D DMOJ57D DN PMID7629799C2d DMOJ57D MI TTFQEO5 DMOJ57D MN Squalene synthetase (FDFT1) DMOJ57D MT DTT DMOJ57D MA Inhibitor DMOJ57D RN 1,1-Bisphosphonate squalene synthase inhibitors: interplay between the isoprenoid subunit and the diphosphate surrogate. J Med Chem. 1995 Jul 7;38(14):2596-605. DMOJ57D RU https://pubmed.ncbi.nlm.nih.gov/7629799 DMBRH0Q DI DMBRH0Q DMBRH0Q DN PMID7629799C2e DMBRH0Q MI TTFQEO5 DMBRH0Q MN Squalene synthetase (FDFT1) DMBRH0Q MT DTT DMBRH0Q MA Inhibitor DMBRH0Q RN 1,1-Bisphosphonate squalene synthase inhibitors: interplay between the isoprenoid subunit and the diphosphate surrogate. J Med Chem. 1995 Jul 7;38(14):2596-605. DMBRH0Q RU https://pubmed.ncbi.nlm.nih.gov/7629799 DMXMF39 DI DMXMF39 DMXMF39 DN PMID7629799C6 DMXMF39 MI TTFQEO5 DMXMF39 MN Squalene synthetase (FDFT1) DMXMF39 MT DTT DMXMF39 MA Inhibitor DMXMF39 RN Phosphonosulfonates are potent, selective inhibitors of dehydrosqualene synthase and staphyloxanthin biosynthesis in Staphylococcus aureus. J Med Chem. 2009 Feb 26;52(4):976-88. DMXMF39 RU https://pubmed.ncbi.nlm.nih.gov/19191557 DM5SU6N DI DM5SU6N DM5SU6N DN PMID7650673C4q DM5SU6N MI TTFQEO5 DM5SU6N MN Squalene synthetase (FDFT1) DM5SU6N MT DTT DM5SU6N MA Inhibitor DM5SU6N RN (Aryloxy)methylsilane derivatives as new cholesterol biosynthesis inhibitors: synthesis and hypocholesterolemic activity of a new class of squalene epoxidase inhibitors. J Med Chem. 1995 Aug 18;38(17):3207-16. DM5SU6N RU https://pubmed.ncbi.nlm.nih.gov/7650673 DM769YQ DI DM769YQ DM769YQ DN PMID7932551C9 DM769YQ MI TTPADOQ DM769YQ MN HMG-CoA reductase (HMGCR) DM769YQ MT DTT DM769YQ MA Inhibitor DM769YQ RN Synthesis and biological activity of bile acid-derived HMG-CoA reductase inhibitors. The role of 21-methyl in recognition of HMG-CoA reductase and the ileal bile acid transport system. J Med Chem. 1994 Sep 30;37(20):3240-6. DM769YQ RU https://pubmed.ncbi.nlm.nih.gov/7932551 DMJF7OC DI DMJF7OC DMJF7OC DN PMID7966163C3f DMJF7OC MI TTFQEO5 DMJF7OC MN Squalene synthetase (FDFT1) DMJF7OC MT DTT DMJF7OC MA Inhibitor DMJF7OC RN Structure-activity relationships of C1 and C6 side chains of zaragozic acid A derivatives. J Med Chem. 1994 Nov 11;37(23):4031-51. DMJF7OC RU https://pubmed.ncbi.nlm.nih.gov/7966163 DMD524S DI DMD524S DMD524S DN PMID7966163C4e DMD524S MI TTFQEO5 DMD524S MN Squalene synthetase (FDFT1) DMD524S MT DTT DMD524S MA Inhibitor DMD524S RN Structure-activity relationships of C1 and C6 side chains of zaragozic acid A derivatives. J Med Chem. 1994 Nov 11;37(23):4031-51. DMD524S RU https://pubmed.ncbi.nlm.nih.gov/7966163 DMUEG8O DI DMUEG8O DMUEG8O DN PMID7966163C6c DMUEG8O MI TTFQEO5 DMUEG8O MN Squalene synthetase (FDFT1) DMUEG8O MT DTT DMUEG8O MA Inhibitor DMUEG8O RN Structure-activity relationships of C1 and C6 side chains of zaragozic acid A derivatives. J Med Chem. 1994 Nov 11;37(23):4031-51. DMUEG8O RU https://pubmed.ncbi.nlm.nih.gov/7966163 DM0XU3C DI DM0XU3C DM0XU3C DN PMID7966163C6d DM0XU3C MI TTFQEO5 DM0XU3C MN Squalene synthetase (FDFT1) DM0XU3C MT DTT DM0XU3C MA Inhibitor DM0XU3C RN Structure-activity relationships of C1 and C6 side chains of zaragozic acid A derivatives. J Med Chem. 1994 Nov 11;37(23):4031-51. DM0XU3C RU https://pubmed.ncbi.nlm.nih.gov/7966163 DM8T41N DI DM8T41N DM8T41N DN PMID7966163C6g DM8T41N MI TTFQEO5 DM8T41N MN Squalene synthetase (FDFT1) DM8T41N MT DTT DM8T41N MA Inhibitor DM8T41N RN Structure-activity relationships of C1 and C6 side chains of zaragozic acid A derivatives. J Med Chem. 1994 Nov 11;37(23):4031-51. DM8T41N RU https://pubmed.ncbi.nlm.nih.gov/7966163 DMRGY2X DI DMRGY2X DMRGY2X DN PMID8246233C28 DMRGY2X MI TTPADOQ DMRGY2X MN HMG-CoA reductase (HMGCR) DMRGY2X MT DTT DMRGY2X MA Inhibitor DMRGY2X RN Inhibitors of cholesterol biosynthesis. 1. 3,5-Dihydroxy-7-(N-imidazolyl)-6-heptenoates and -heptanoates, a novel series of HMG-CoA reductase inhibitors. J Med Chem. 1993 Nov 12;36(23):3646-57. DMRGY2X RU https://pubmed.ncbi.nlm.nih.gov/8246233 DMUJ9F7 DI DMUJ9F7 DMUJ9F7 DN PMID8246233C35 DMUJ9F7 MI TTPADOQ DMUJ9F7 MN HMG-CoA reductase (HMGCR) DMUJ9F7 MT DTT DMUJ9F7 MA Inhibitor DMUJ9F7 RN Inhibitors of cholesterol biosynthesis. 1. 3,5-Dihydroxy-7-(N-imidazolyl)-6-heptenoates and -heptanoates, a novel series of HMG-CoA reductase inhibitors. J Med Chem. 1993 Nov 12;36(23):3646-57. DMUJ9F7 RU https://pubmed.ncbi.nlm.nih.gov/8246233 DMETHN7 DI DMETHN7 DMETHN7 DN PMID8246233C5ab DMETHN7 MI TTPADOQ DMETHN7 MN HMG-CoA reductase (HMGCR) DMETHN7 MT DTT DMETHN7 MA Inhibitor DMETHN7 RN Inhibitors of cholesterol biosynthesis. 1. 3,5-Dihydroxy-7-(N-imidazolyl)-6-heptenoates and -heptanoates, a novel series of HMG-CoA reductase inhibitors. J Med Chem. 1993 Nov 12;36(23):3646-57. DMETHN7 RU https://pubmed.ncbi.nlm.nih.gov/8246233 DMJWEXQ DI DMJWEXQ DMJWEXQ DN PMID8246234C3h DMJWEXQ MI TTPADOQ DMJWEXQ MN HMG-CoA reductase (HMGCR) DMJWEXQ MT DTT DMJWEXQ MA Inhibitor DMJWEXQ RN Inhibitors of cholesterol biosynthesis. 2. 3,5-Dihydroxy-7-(N-pyrrolyl)-6-heptenoates, a novel series of HMG-CoA reductase inhibitors. J Med Chem. 1993 Nov 12;36(23):3658-62. DMJWEXQ RU https://pubmed.ncbi.nlm.nih.gov/8246234 DMLOR6F DI DMLOR6F DMLOR6F DN PMID8246237C18t DMLOR6F MI TTPADOQ DMLOR6F MN HMG-CoA reductase (HMGCR) DMLOR6F MT DTT DMLOR6F MA Inhibitor DMLOR6F RN HMG-CoA reductase inhibitors: design, synthesis, and biological activity of tetrahydroindazole-substituted 3,5-dihydroxy-6-heptenoic acid sodium salts. J Med Chem. 1993 Nov 12;36(23):3674-85. DMLOR6F RU https://pubmed.ncbi.nlm.nih.gov/8246237 DMEITGU DI DMEITGU DMEITGU DN PMID8410973C2 DMEITGU MI TTLXC4Q DMEITGU MN Cathepsin E (CTSE) DMEITGU MT DTT DMEITGU MA Inhibitor DMEITGU RN Specificity in the binding of inhibitors to the active site of human/primate aspartic proteinases: analysis of P2-P1-P1'-P2' variation. J Med Chem. 1993 Sep 3;36(18):2614-20. DMEITGU RU https://pubmed.ncbi.nlm.nih.gov/8410973 DM6J5KY DI DM6J5KY DM6J5KY DN PMID8410973C3 DM6J5KY MI TTPT2QI DM6J5KY MN Cathepsin D (CTSD) DM6J5KY MT DTT DM6J5KY MA Inhibitor DM6J5KY RN Specificity in the binding of inhibitors to the active site of human/primate aspartic proteinases: analysis of P2-P1-P1'-P2' variation. J Med Chem. 1993 Sep 3;36(18):2614-20. DM6J5KY RU https://pubmed.ncbi.nlm.nih.gov/8410973 DM6J5KY DI DM6J5KY DM6J5KY DN PMID8410973C3 DM6J5KY MI TTLXC4Q DM6J5KY MN Cathepsin E (CTSE) DM6J5KY MT DTT DM6J5KY MA Inhibitor DM6J5KY RN Specificity in the binding of inhibitors to the active site of human/primate aspartic proteinases: analysis of P2-P1-P1'-P2' variation. J Med Chem. 1993 Sep 3;36(18):2614-20. DM6J5KY RU https://pubmed.ncbi.nlm.nih.gov/8410973 DM6J5KY DI DM6J5KY DM6J5KY DN PMID8410973C3 DM6J5KY MI TTKZ864 DM6J5KY MN Pepsinogen-5 (PGA5) DM6J5KY MT DTT DM6J5KY MA Inhibitor DM6J5KY RN Specificity in the binding of inhibitors to the active site of human/primate aspartic proteinases: analysis of P2-P1-P1'-P2' variation. J Med Chem. 1993 Sep 3;36(18):2614-20. DM6J5KY RU https://pubmed.ncbi.nlm.nih.gov/8410973 DM6J5KY DI DM6J5KY DM6J5KY DN PMID8410973C3 DM6J5KY MI TT7K6AD DM6J5KY MN Progastricsin pepsinogen C (PGC) DM6J5KY MT DTT DM6J5KY MA Inhibitor DM6J5KY RN Specificity in the binding of inhibitors to the active site of human/primate aspartic proteinases: analysis of P2-P1-P1'-P2' variation. J Med Chem. 1993 Sep 3;36(18):2614-20. DM6J5KY RU https://pubmed.ncbi.nlm.nih.gov/8410973 DMTURQZ DI DMTURQZ DMTURQZ DN PMID8426367C18 DMTURQZ MI TTPADOQ DMTURQZ MN HMG-CoA reductase (HMGCR) DMTURQZ MT DTT DMTURQZ MA Inhibitor DMTURQZ RN 32-Methyl-32-oxylanosterols: dual-action inhibitors of cholesterol biosynthesis. J Med Chem. 1993 Feb 5;36(3):410-6. DMTURQZ RU https://pubmed.ncbi.nlm.nih.gov/8426367 DM8PBKQ DI DM8PBKQ DM8PBKQ DN PMID8496919C7 DM8PBKQ MI TTFQEO5 DM8PBKQ MN Squalene synthetase (FDFT1) DM8PBKQ MT DTT DM8PBKQ MA Inhibitor DM8PBKQ RN N-(arylalkyl)farnesylamines: new potent squalene synthetase inhibitors. J Med Chem. 1993 May 14;36(10):1501-4. DM8PBKQ RU https://pubmed.ncbi.nlm.nih.gov/8496919 DMG3ZD1 DI DMG3ZD1 DMG3ZD1 DN PMID8568816C56 DMG3ZD1 MI TTGKNB4 DMG3ZD1 MN Epidermal growth factor receptor (EGFR) DMG3ZD1 MT DTT DMG3ZD1 MA Inhibitor DMG3ZD1 RN Tyrosine kinase inhibitors. 8. An unusually steep structure-activity relationship for analogues of 4-(3-bromoanilino)-6,7-dimethoxyquinazoline (PD 153035), a potent inhibitor of the epidermal growth factor receptor. J Med Chem. 1996 Jan 5;39(1):267-76. DMG3ZD1 RU https://pubmed.ncbi.nlm.nih.gov/8568816 DMUJEA4 DI DMUJEA4 DMUJEA4 DN PMID8576905C4 DMUJEA4 MI TTFQEO5 DMUJEA4 MN Squalene synthetase (FDFT1) DMUJEA4 MT DTT DMUJEA4 MA Inhibitor DMUJEA4 RN Alpha-Phosphonosulfonic acids: potent and selective inhibitors of squalene synthase. J Med Chem. 1996 Feb 2;39(3):657-60. DMUJEA4 RU https://pubmed.ncbi.nlm.nih.gov/8576905 DMWBPOJ DI DMWBPOJ DMWBPOJ DN PMID8709131C15 DMWBPOJ MI TTFQEO5 DMWBPOJ MN Squalene synthetase (FDFT1) DMWBPOJ MT DTT DMWBPOJ MA Inhibitor DMWBPOJ RN Synthesis and activity of a novel series of 3-biarylquinuclidine squalene synthase inhibitors. J Med Chem. 1996 Jul 19;39(15):2971-9. DMWBPOJ RU https://pubmed.ncbi.nlm.nih.gov/8709131 DM10IQP DI DM10IQP DM10IQP DN PMID8709131C17 DM10IQP MI TTFQEO5 DM10IQP MN Squalene synthetase (FDFT1) DM10IQP MT DTT DM10IQP MA Inhibitor DM10IQP RN Synthesis and activity of a novel series of 3-biarylquinuclidine squalene synthase inhibitors. J Med Chem. 1996 Jul 19;39(15):2971-9. DM10IQP RU https://pubmed.ncbi.nlm.nih.gov/8709131 DMSKJ53 DI DMSKJ53 DMSKJ53 DN PMID8709131C23 DMSKJ53 MI TTFQEO5 DMSKJ53 MN Squalene synthetase (FDFT1) DMSKJ53 MT DTT DMSKJ53 MA Inhibitor DMSKJ53 RN Synthesis and activity of a novel series of 3-biarylquinuclidine squalene synthase inhibitors. J Med Chem. 1996 Jul 19;39(15):2971-9. DMSKJ53 RU https://pubmed.ncbi.nlm.nih.gov/8709131 DM1OS6M DI DM1OS6M DM1OS6M DN PMID8709131C2a (+) DM1OS6M MI TTFQEO5 DM1OS6M MN Squalene synthetase (FDFT1) DM1OS6M MT DTT DM1OS6M MA Inhibitor DM1OS6M RN Synthesis and activity of a novel series of 3-biarylquinuclidine squalene synthase inhibitors. J Med Chem. 1996 Jul 19;39(15):2971-9. DM1OS6M RU https://pubmed.ncbi.nlm.nih.gov/8709131 DMETC8A DI DMETC8A DMETC8A DN PMID8709131C4 DMETC8A MI TTFQEO5 DMETC8A MN Squalene synthetase (FDFT1) DMETC8A MT DTT DMETC8A MA Inhibitor DMETC8A RN Synthesis and activity of a novel series of 3-biarylquinuclidine squalene synthase inhibitors. J Med Chem. 1996 Jul 19;39(15):2971-9. DMETC8A RU https://pubmed.ncbi.nlm.nih.gov/8709131 DMM08LV DI DMM08LV DMM08LV DN PMID8831774C19 DMM08LV MI TTG5QB7 DMM08LV MN Calpain-2 (CAPN2) DMM08LV MT DTT DMM08LV MA Inhibitor DMM08LV RN Novel peptidyl alpha-keto amide inhibitors of calpains and other cysteine proteases. J Med Chem. 1996 Sep 27;39(20):4089-98. DMM08LV RU https://pubmed.ncbi.nlm.nih.gov/8831774 DM1I578 DI DM1I578 DM1I578 DN PMID9003518C3 DM1I578 MI TT7O8ZA DM1I578 MN Lanosterol synthase (LSS) DM1I578 MT DTT DM1I578 MA Inhibitor DM1I578 RN Synthesis and inhibition studies of sulfur-substituted squalene oxide analogues as mechanism-based inhibitors of 2,3-oxidosqualene-lanosterol cyclase. J Med Chem. 1997 Jan 17;40(2):201-9. DM1I578 RU https://pubmed.ncbi.nlm.nih.gov/9003518 DMYE64O DI DMYE64O DMYE64O DN PMID9003518C4 DMYE64O MI TT7O8ZA DMYE64O MN Lanosterol synthase (LSS) DMYE64O MT DTT DMYE64O MA Inhibitor DMYE64O RN Synthesis and inhibition studies of sulfur-substituted squalene oxide analogues as mechanism-based inhibitors of 2,3-oxidosqualene-lanosterol cyclase. J Med Chem. 1997 Jan 17;40(2):201-9. DMYE64O RU https://pubmed.ncbi.nlm.nih.gov/9003518 DM2F81A DI DM2F81A DM2F81A DN PMID9216829C5j DM2F81A MI TTFQEO5 DM2F81A MN Squalene synthetase (FDFT1) DM2F81A MT DTT DM2F81A MA Inhibitor DM2F81A RN (1 alpha, 2 beta, 3 beta, 4 alpha)-1,2-bis[N-propyl-N-(4-phenoxybenzyl) amino]carbonyl]cyclobutane-3,4-dicarboxylic acid (A-87049): a novel potent ... J Med Chem. 1997 Jul 4;40(14):2123-5. DM2F81A RU https://pubmed.ncbi.nlm.nih.gov/9216829 DM3ARWX DI DM3ARWX DM3ARWX DN PMID9216829C5m DM3ARWX MI TTFQEO5 DM3ARWX MN Squalene synthetase (FDFT1) DM3ARWX MT DTT DM3ARWX MA Inhibitor DM3ARWX RN (1 alpha, 2 beta, 3 beta, 4 alpha)-1,2-bis[N-propyl-N-(4-phenoxybenzyl) amino]carbonyl]cyclobutane-3,4-dicarboxylic acid (A-87049): a novel potent ... J Med Chem. 1997 Jul 4;40(14):2123-5. DM3ARWX RU https://pubmed.ncbi.nlm.nih.gov/9216829 DMY28QM DI DMY28QM DMY28QM DN PMID9871507C14 DMY28QM MI TTFQEO5 DMY28QM MN Squalene synthetase (FDFT1) DMY28QM MT DTT DMY28QM MA Inhibitor DMY28QM RN Cyclopentanedi- and tricarboxylic acids as squalene synthase inhibitors: syntheses and evaluation. Bioorg Med Chem Lett. 1998 Apr 21;8(8):891-6. DMY28QM RU https://pubmed.ncbi.nlm.nih.gov/9871507 DMHSWT6 DI DMHSWT6 DMHSWT6 DN P-MPPI DMHSWT6 MI TTSQIFT DMHSWT6 MN 5-HT 1A receptor (HTR1A) DMHSWT6 MT DTT DMHSWT6 MA Antagonist DMHSWT6 RN p-Chloroamphetamine, a serotonin-releasing drug, elicited in rats a hyperglycemia mediated by the 5-HT1A and 5-HT2B/2C receptors. Eur J Pharmacol. 1998 Oct 23;359(2-3):185-90. DMHSWT6 RU https://pubmed.ncbi.nlm.nih.gov/9832390 DMZCSF1 DI DMZCSF1 DMZCSF1 DN PMX-700 DMZCSF1 MI TT6S2FE DMZCSF1 MN DNA [cytosine-5]-methyltransferase 1 (DNMT1) DMZCSF1 MT DTT DMZCSF1 MA Modulator DMZCSF1 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2605). DMZCSF1 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2605 DMPUC8I DI DMPUC8I DMPUC8I DN PNA-D-glucopyranoside DMPUC8I MI DEQB4LT DMPUC8I MN Beta-galactosidase (bgaB) DMPUC8I MT DME DMPUC8I MA Metabolism DMPUC8I RN Identification and characterization of a novel beta-galactosidase from Victivallis vadensis ATCC BAA-548, an anaerobic fecal bacterium. J Microbiol. 2012 Dec;50(6):1034-40. DMPUC8I RU https://pubmed.ncbi.nlm.nih.gov/23274992 DMPUC8I DI DMPUC8I DMPUC8I DN PNA-D-glucopyranoside DMPUC8I MI DEPR1Y7 DMPUC8I MN Beta-galactosidase (bgaB) DMPUC8I MT DME DMPUC8I MA Metabolism DMPUC8I RN Beta-galactosidase from Bifidobacterium adolescentis DSM20083 prefers beta(1,4)-galactosides over lactose. Appl Microbiol Biotechnol. 2004 Dec;66(3):276-84. DMPUC8I RU https://pubmed.ncbi.nlm.nih.gov/15480628 DMPUC8I DI DMPUC8I DMPUC8I DN PNA-D-glucopyranoside DMPUC8I MI DE073GW DMPUC8I MN Glucosidase II beta (PRKCSH) DMPUC8I MT DME DMPUC8I MA Metabolism DMPUC8I RN The heterodimeric structure of glucosidase II is required for its activity, solubility, and localization in vivo. Glycobiology. 2000 Aug;10(8):815-27. DMPUC8I RU https://www.ncbi.nlm.nih.gov/pubmed/?term=10929008 DMPUC8I DI DMPUC8I DMPUC8I DN PNA-D-glucopyranoside DMPUC8I MI DEMWKYT DMPUC8I MN Neutral alpha-glucosidase AB (GANAB) DMPUC8I MT DME DMPUC8I MA Metabolism DMPUC8I RN The heterodimeric structure of glucosidase II is required for its activity, solubility, and localization in vivo. Glycobiology. 2000 Aug;10(8):815-27. DMPUC8I RU https://www.ncbi.nlm.nih.gov/pubmed/?term=10929008 DMZF7RQ DI DMZF7RQ DMZF7RQ DN PNA-l-rhamnopyranoside DMZF7RQ MI DEBI82Z DMZF7RQ MN Alpha-L-rhamnosidase (lrA) DMZF7RQ MT DME DMZF7RQ MA Metabolism DMZF7RQ RN Metabolism of rutin and poncirin by human intestinal microbiota and cloning of their metabolizing alpha-L-rhamnosidase from Bifidobacterium dentium. J Microbiol Biotechnol. 2015 Jan;25(1):18-25. DMZF7RQ RU https://pubmed.ncbi.nlm.nih.gov/25179902 DMBK8QI DI DMBK8QI DMBK8QI DN PNB-D-glucoside DMBK8QI MI DE21ZKX DMBK8QI MN GH3 beta-glucosidase (BAD1610) DMBK8QI MT DME DMBK8QI MA Metabolism DMBK8QI RN Structural and biochemical characterization of a GH3 beta-glucosidase from the probiotic bacteria Bifidobacterium adolescentis. Biochimie. 2018 May;148:107-115. DMBK8QI RU https://pubmed.ncbi.nlm.nih.gov/29555372 DMZ91P5 DI DMZ91P5 DMZ91P5 DN PNB-D-glucuronide DMZ91P5 MI DE65RJO DMZ91P5 MN Beta-glucuronidase (uidA) DMZ91P5 MT DME DMZ91P5 MA Metabolism DMZ91P5 RN Active site flexibility revealed in crystal structures of Parabacteroides merdae beta-glucuronidase from the human gut microbiome. Protein Sci. 2018 Dec;27(12):2010-2022. DMZ91P5 RU https://pubmed.ncbi.nlm.nih.gov/30230652 DMWPECH DI DMWPECH DMWPECH DN PNB-D-xyloside DMWPECH MI DEG1VAR DMWPECH MN Beta-glucuronidase (uidA) DMWPECH MT DME DMWPECH MA Metabolism DMWPECH RN Structural and biochemical characterization of glycoside hydrolase family 79 beta-glucuronidase from Acidobacterium capsulatum. J Biol Chem. 2012 Apr 20;287(17):14069-77. DMWPECH RU https://pubmed.ncbi.nlm.nih.gov/22367201 DMWPECH DI DMWPECH DMWPECH DN PNB-D-xyloside DMWPECH MI DE21ZKX DMWPECH MN GH3 beta-glucosidase (BAD1610) DMWPECH MT DME DMWPECH MA Metabolism DMWPECH RN Structural and biochemical characterization of a GH3 beta-glucosidase from the probiotic bacteria Bifidobacterium adolescentis. Biochimie. 2018 May;148:107-115. DMWPECH RU https://pubmed.ncbi.nlm.nih.gov/29555372 DMVJUOZ DI DMVJUOZ DMVJUOZ DN P-nitrobenzoic acid DMVJUOZ MI DEAVXGM DMVJUOZ MN Nitroreductase (NTR) DMVJUOZ MT DME DMVJUOZ MA Metabolism DMVJUOZ RN Isolation of nitrofurantoin-resistant mutants of nitroreductase-producing Clostridium sp. strains from the human intestinal tract. Antimicrob Agents Chemother. 1998 May;42(5):1121-6. DMVJUOZ RU https://pubmed.ncbi.nlm.nih.gov/9593138 DMVJUOZ DI DMVJUOZ DMVJUOZ DN P-nitrobenzoic acid DMVJUOZ MI DE7XBKW DMVJUOZ MN Nitroreductase (NTR) DMVJUOZ MT DME DMVJUOZ MA Metabolism DMVJUOZ RN Isolation of nitrofurantoin-resistant mutants of nitroreductase-producing Clostridium sp. strains from the human intestinal tract. Antimicrob Agents Chemother. 1998 May;42(5):1121-6. DMVJUOZ RU https://pubmed.ncbi.nlm.nih.gov/9593138 DMVJUOZ DI DMVJUOZ DMVJUOZ DN P-nitrobenzoic acid DMVJUOZ MI DEP7ECA DMVJUOZ MN Nitroreductase (NTR) DMVJUOZ MT DME DMVJUOZ MA Metabolism DMVJUOZ RN Isolation of nitrofurantoin-resistant mutants of nitroreductase-producing Clostridium sp. strains from the human intestinal tract. Antimicrob Agents Chemother. 1998 May;42(5):1121-6. DMVJUOZ RU https://pubmed.ncbi.nlm.nih.gov/9593138 DMVJUOZ DI DMVJUOZ DMVJUOZ DN P-nitrobenzoic acid DMVJUOZ MI DEH3ABM DMVJUOZ MN Nitroreductase (NTR) DMVJUOZ MT DME DMVJUOZ MA Metabolism DMVJUOZ RN Isolation of nitrofurantoin-resistant mutants of nitroreductase-producing Clostridium sp. strains from the human intestinal tract. Antimicrob Agents Chemother. 1998 May;42(5):1121-6. DMVJUOZ RU https://pubmed.ncbi.nlm.nih.gov/9593138 DM7LPCE DI DM7LPCE DM7LPCE DN P-nitrophenyl DM7LPCE MI DEMH6UB DM7LPCE MN Lysosomal beta A mannosidase (MANBA) DM7LPCE MT DME DM7LPCE MA Metabolism DM7LPCE RN Cloning, sequence, expression and characterization of human beta-mannosidase. Acta Biochim Pol. 2008;55(3):479-90. DM7LPCE RU https://www.ncbi.nlm.nih.gov/pubmed/?term=18800177 DM29RO1 DI DM29RO1 DM29RO1 DN P-Nitrophenyl Glutamyl Anilide DM29RO1 MI TTF7WRM DM29RO1 MN Alanine/serine/cysteine transporter 2 (SLC1A5) DM29RO1 MT DTT DM29RO1 MA Inhibitor DM29RO1 RN Ngamma-aryl glutamine analogues as probes of the ASCT2 neutral amino acid transporter binding site. Bioorg Med Chem. 2005 Feb 15;13(4):1111-8. DM29RO1 RU https://pubmed.ncbi.nlm.nih.gov/15670919 DMDBZGP DI DMDBZGP DMDBZGP DN PNRI-299 DMDBZGP MI TTN3GBV DMDBZGP MN Transcription factor AP-1 (JUN) DMDBZGP MT DTT DMDBZGP MA Inhibitor DMDBZGP RN Chemogenomic identification of Ref-1/AP-1 as a therapeutic target for asthma. Proc Natl Acad Sci U S A. 2003 Feb 4;100(3):1169-73. DMDBZGP RU https://pubmed.ncbi.nlm.nih.gov/12552119 DM8WJQ0 DI DM8WJQ0 DM8WJQ0 DN PNT-300 DM8WJQ0 MI TTM8FR7 DM8WJQ0 MN KRAS messenger RNA (KRAS mRNA) DM8WJQ0 MT DTT DM8WJQ0 MA Inhibitor DM8WJQ0 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2824). DM8WJQ0 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2824 DMIEKVB DI DMIEKVB DMIEKVB DN PNT-500 DMIEKVB MI TTR5TV4 DMIEKVB MN ERBB2 messenger RNA (HER2 mRNA) DMIEKVB MT DTT DMIEKVB MA Inhibitor DMIEKVB RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2019). DMIEKVB RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2019 DMKBCS2 DI DMKBCS2 DMKBCS2 DN PNU 101017 DMKBCS2 MI TTEX6LM DMKBCS2 MN GABA(A) receptor gamma-3 (GABRG3) DMKBCS2 MT DTT DMKBCS2 MA Modulator DMKBCS2 RN Neuroprotective effects of the GABA(A) receptor partial agonist U-101017 in 3-acetylpyridine-treated rats. Neurosci Lett. 1997 May 30;228(1):45-9. DMKBCS2 RU https://www.ncbi.nlm.nih.gov/pubmed/9197284 DMS5XRY DI DMS5XRY DMS5XRY DN PNU-107859 DMS5XRY MI TTLM12X DMS5XRY MN Matrix metalloproteinase-2 (MMP-2) DMS5XRY MT DTT DMS5XRY MA Inhibitor DMS5XRY RN A molecular basis for the selectivity of thiadiazole urea inhibitors with stromelysin-1 and gelatinase-A from generalized born molecular dynamics s... J Med Chem. 2004 Jun 3;47(12):3065-74. DMS5XRY RU https://pubmed.ncbi.nlm.nih.gov/15163188 DMS5XRY DI DMS5XRY DMS5XRY DN PNU-107859 DMS5XRY MI TTUZ2L5 DMS5XRY MN Matrix metalloproteinase-3 (MMP-3) DMS5XRY MT DTT DMS5XRY MA Inhibitor DMS5XRY RN A molecular basis for the selectivity of thiadiazole urea inhibitors with stromelysin-1 and gelatinase-A from generalized born molecular dynamics s... J Med Chem. 2004 Jun 3;47(12):3065-74. DMS5XRY RU https://pubmed.ncbi.nlm.nih.gov/15163188 DMYBQM7 DI DMYBQM7 DMYBQM7 DN PNU-120596 DMYBQM7 MI TTLA931 DMYBQM7 MN Neuronal acetylcholine receptor alpha-7 (CHRNA7) DMYBQM7 MT DTT DMYBQM7 MA Modulator (allosteric modulator) DMYBQM7 RN A novel positive allosteric modulator of the alpha7 neuronal nicotinic acetylcholine receptor: in vitro and in vivo characterization. J Neurosci. 2005 Apr 27;25(17):4396-405. DMYBQM7 RU https://pubmed.ncbi.nlm.nih.gov/15858066 DMEI0S7 DI DMEI0S7 DMEI0S7 DN PNU-142372 DMEI0S7 MI TTUZ2L5 DMEI0S7 MN Matrix metalloproteinase-3 (MMP-3) DMEI0S7 MT DTT DMEI0S7 MA Inhibitor DMEI0S7 RN Protease inhibitors: synthesis of matrix metalloproteinase and bacterial collagenase inhibitors incorporating 5-amino-2-mercapto-1,3,4-thiadiazole ... Bioorg Med Chem Lett. 2002 Oct 7;12(19):2667-72. DMEI0S7 RU https://pubmed.ncbi.nlm.nih.gov/12217351 DMM0EYR DI DMM0EYR DMM0EYR DN PNU177836 DMM0EYR MI TTELIN2 DMM0EYR MN PTPN1 messenger RNA (PTPN1 mRNA) DMM0EYR MT DTT DMM0EYR MA Inhibitor DMM0EYR RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMM0EYR RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMHTPSF DI DMHTPSF DMHTPSF DN PNU-22394 DMHTPSF MI TT3WG5C DMHTPSF MN Monoamine oxidase type A (MAO-A) DMHTPSF MT DTT DMHTPSF MA Inhibitor DMHTPSF RN Binding of beta-carbolines at imidazoline I2 receptors: a structure-affinity investigation. Bioorg Med Chem Lett. 2004 Feb 23;14(4):999-1002. DMHTPSF RU https://pubmed.ncbi.nlm.nih.gov/15013009 DMHTPSF DI DMHTPSF DMHTPSF DN PNU-22394 DMHTPSF MI TTGP7BY DMHTPSF MN Monoamine oxidase type B (MAO-B) DMHTPSF MT DTT DMHTPSF MA Inhibitor DMHTPSF RN Binding of beta-carbolines at imidazoline I2 receptors: a structure-affinity investigation. Bioorg Med Chem Lett. 2004 Feb 23;14(4):999-1002. DMHTPSF RU https://pubmed.ncbi.nlm.nih.gov/15013009 DM43K1D DI DM43K1D DM43K1D DN PNU-248686A DM43K1D MI TT1GHVO DM43K1D MN Matrix metalloproteinase (MMP) DM43K1D MT DTT DM43K1D MA Modulator DM43K1D RN Determination of PNU-248686A, a novel matrix metalloproteinase inhibitor, in human plasma by liquid chromatography-tandem mass spectrometry, following protein precipitation in the 96-well plate format. J Chromatogr A. 2003 Feb 14;987(1-2):249-56. DM43K1D RU https://pubmed.ncbi.nlm.nih.gov/12613819 DM6SZVE DI DM6SZVE DM6SZVE DN PNU-87663 DM6SZVE MI TT4QPUL DM6SZVE MN Antithrombin-III (ATIII) DM6SZVE MT DTT DM6SZVE MA Modulator DM6SZVE RN List of drugs in development for neurodegenerative diseases.Update June 2004.Neurodegener Dis.2004;1(2-3):113-52. DM6SZVE RU https://www.ncbi.nlm.nih.gov/pubmed/16908983 DMQMDSG DI DMQMDSG DMQMDSG DN PO3 2-Ile-Trp-O-3K DMQMDSG MI TTQ9RYT DMQMDSG MN Endothelin-converting enzyme 1 (ECE1) DMQMDSG MT DTT DMQMDSG MA Inhibitor DMQMDSG RN Aminophosphonate endothelin converting enzyme inhibitors: potency-enhancing and selectivity-improving modifications of phosphoramidon, Bioorg. Med. Chem. Lett. 4(10):1257-1262 (1994). DMQMDSG RU http://www.sciencedirect.com/science/article/pii/S0960894X01803413 DMY43FU DI DMY43FU DMY43FU DN PO3 2-Leu-Nal-O-3K DMY43FU MI TTQ9RYT DMY43FU MN Endothelin-converting enzyme 1 (ECE1) DMY43FU MT DTT DMY43FU MA Inhibitor DMY43FU RN Aminophosphonate endothelin converting enzyme inhibitors: potency-enhancing and selectivity-improving modifications of phosphoramidon, Bioorg. Med. Chem. Lett. 4(10):1257-1262 (1994). DMY43FU RU http://www.sciencedirect.com/science/article/pii/S0960894X01803413 DM3O78D DI DM3O78D DM3O78D DN PO3 2-Leu-Trp-O-3K DM3O78D MI TTQ9RYT DM3O78D MN Endothelin-converting enzyme 1 (ECE1) DM3O78D MT DTT DM3O78D MA Inhibitor DM3O78D RN Aminophosphonate endothelin converting enzyme inhibitors: potency-enhancing and selectivity-improving modifications of phosphoramidon, Bioorg. Med. Chem. Lett. 4(10):1257-1262 (1994). DM3O78D RU http://www.sciencedirect.com/science/article/pii/S0960894X01803413 DMW1XY4 DI DMW1XY4 DMW1XY4 DN PO3 2-Nle-Trp-O-3K DMW1XY4 MI TTQ9RYT DMW1XY4 MN Endothelin-converting enzyme 1 (ECE1) DMW1XY4 MT DTT DMW1XY4 MA Inhibitor DMW1XY4 RN Aminophosphonate endothelin converting enzyme inhibitors: potency-enhancing and selectivity-improving modifications of phosphoramidon, Bioorg. Med. Chem. Lett. 4(10):1257-1262 (1994). DMW1XY4 RU http://www.sciencedirect.com/science/article/pii/S0960894X01803413 DMURB4Y DI DMURB4Y DMURB4Y DN pobilukast DMURB4Y MI TTGKOY9 DMURB4Y MN Leukotriene CysLT1 receptor (CYSLTR1) DMURB4Y MT DTT DMURB4Y MA Antagonist DMURB4Y RN Identification, molecular cloning, expression, and characterization of a cysteinyl leukotriene receptor. Mol Pharmacol. 1999 Sep;56(3):657-63. DMURB4Y RU https://pubmed.ncbi.nlm.nih.gov/10462554 DMURB4Y DI DMURB4Y DMURB4Y DN pobilukast DMURB4Y MI TT0PZR5 DMURB4Y MN Leukotriene CysLT2 receptor (CYSLTR2) DMURB4Y MT DTT DMURB4Y MA Antagonist DMURB4Y RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 270). DMURB4Y RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=270 DMXA4HY DI DMXA4HY DMXA4HY DN Poly IC-poly arginine DMXA4HY MI TTD24Y0 DMXA4HY MN Toll-like receptor 3 (TLR3) DMXA4HY MT DTT DMXA4HY RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1753). DMXA4HY RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1753 DMG7K84 DI DMG7K84 DMG7K84 DN Polybrominated diphenyl ether derivative DMG7K84 MI TT12ABZ DMG7K84 MN Arachidonate 12-lipoxygenase (12-LOX) DMG7K84 MT DTT DMG7K84 MA Inhibitor DMG7K84 RN Probing the activity differences of simple and complex brominated aryl compounds against 15-soybean, 15-human, and 12-human lipoxygenase. J Med Chem. 2004 Jul 29;47(16):4060-5. DMG7K84 RU https://pubmed.ncbi.nlm.nih.gov/15267244 DMG7K84 DI DMG7K84 DMG7K84 DN Polybrominated diphenyl ether derivative DMG7K84 MI TTN9T81 DMG7K84 MN Arachidonate 15-lipoxygenase (15-LOX) DMG7K84 MT DTT DMG7K84 MA Inhibitor DMG7K84 RN Probing the activity differences of simple and complex brominated aryl compounds against 15-soybean, 15-human, and 12-human lipoxygenase. J Med Chem. 2004 Jul 29;47(16):4060-5. DMG7K84 RU https://pubmed.ncbi.nlm.nih.gov/15267244 DMUTV5P DI DMUTV5P DMUTV5P DN POLYGALATENOSIDE B DMUTV5P MI TTAWNKZ DMUTV5P MN Norepinephrine transporter (NET) DMUTV5P MT DTT DMUTV5P MA Inhibitor DMUTV5P RN Antidepressant principles of the roots of Polygala tenuifolia. J Nat Prod. 2006 Sep;69(9):1305-9. DMUTV5P RU https://pubmed.ncbi.nlm.nih.gov/16989524 DMV486E DI DMV486E DMV486E DN polyIC DMV486E MI TTD24Y0 DMV486E MN Toll-like receptor 3 (TLR3) DMV486E MT DTT DMV486E MA Agonist DMV486E RN Recognition of double-stranded RNA and activation of NF-kappaB by Toll-like receptor 3. Nature. 2001 Oct 18;413(6857):732-8. DMV486E RU https://pubmed.ncbi.nlm.nih.gov/11607032 DMUMJ7B DI DMUMJ7B DMUMJ7B DN Poly-ICR DMUMJ7B MI TTD24Y0 DMUMJ7B MN Toll-like receptor 3 (TLR3) DMUMJ7B MT DTT DMUMJ7B MA Agonist DMUMJ7B RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1753). DMUMJ7B RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1753 DM4VZCW DI DM4VZCW DM4VZCW DN Polyinosinic:polycytidylic acid DM4VZCW MI TT1CN09 DM4VZCW MN HUMAN toll-like receptor 3 (TLR3) DM4VZCW MT DTT DM4VZCW MA Agonist DM4VZCW RN Middle East Respiratory Syndrome Coronavirus (MERS-CoV): Infection, Immunological Response, and Vaccine Development. J Immunol Res. 2019 Apr 7;2019:6491738. doi: 10.1155/2019/6491738. DM4VZCW RU https://pubmed.ncbi.nlm.nih.gov/31089478 DMN6Q4E DI DMN6Q4E DMN6Q4E DN Polyporic acid DMN6Q4E MI TT3PQ2Y DMN6Q4E MN Plasmodium Dihydroorotate dehydrogenase (Malaria DHOdehase) DMN6Q4E MT DTT DMN6Q4E MA Inhibitor DMN6Q4E RN Kinetics of inhibition of human and rat dihydroorotate dehydrogenase by atovaquone, lawsone derivatives, brequinar sodium and polyporic acid. Chem Biol Interact. 2000 Jan 3;124(1):61-76. DMN6Q4E RU https://pubmed.ncbi.nlm.nih.gov/10658902 DMRX9E3 DI DMRX9E3 DMRX9E3 DN POLYSIN DMRX9E3 MI TTHQ79V DMRX9E3 MN Trypanosoma Pyrophosphate-dependent phosphofructokinase (Trypano pfk) DMRX9E3 MT DTT DMRX9E3 MA Inhibitor DMRX9E3 RN Antitrypanosomal alkaloids from Polyalthia suaveolens (Annonaceae): their effects on three selected glycolytic enzymes of Trypanosoma brucei. Bioorg Med Chem Lett. 2010 Jun 15;20(12):3495-8. DMRX9E3 RU https://pubmed.ncbi.nlm.nih.gov/20529682 DM1GV7K DI DM1GV7K DM1GV7K DN Pomolic acid DM1GV7K MI TTELIN2 DM1GV7K MN PTPN1 messenger RNA (PTPN1 mRNA) DM1GV7K MT DTT DM1GV7K MA Inhibitor DM1GV7K RN Triterpenoids from the leaves of Diospyros kaki (persimmon) and their inhibitory effects on protein tyrosine phosphatase 1B. J Nat Prod. 2008 Oct;71(10):1775-8. DM1GV7K RU https://pubmed.ncbi.nlm.nih.gov/18798681 DMGRPK8 DI DMGRPK8 DMGRPK8 DN PONKORANOL DMGRPK8 MI TTXWASR DMGRPK8 MN Intestinal maltase-glucoamylase (MGAM) DMGRPK8 MT DTT DMGRPK8 MA Inhibitor DMGRPK8 RN Probing the active-site requirements of human intestinal N-terminal maltase glucoamylase: the effect of replacing the sulfate moiety by a methyl et... Bioorg Med Chem Lett. 2010 Oct 1;20(19):5686-9. DMGRPK8 RU https://pubmed.ncbi.nlm.nih.gov/20801033 DMVTKCX DI DMVTKCX DMVTKCX DN POP-1 DMVTKCX MI TTHCF4J DMVTKCX MN Alpha-glucosidase (GLA) DMVTKCX MT DTT DMVTKCX MA Modulator DMVTKCX RN US patent application no. 2012,0251,516, PHARMACEUTICAL COMPOSITION FOR TREATING CANCER COMPRISING TRYPSINOGEN AND/OR CHYMOTRYPSINOGEN AND AN ACTIVE AGENT SELECTED FROM A SELENIUM COMPOUND, A VANILLOID COMPOUND AND A CYTOPLASMIC GLYCOLYSIS REDUCTION AGENT. DMVTKCX RU http://www.patentbuddy.com/Patent/20120251516?ft=true&sr=true DMVTKCX DI DMVTKCX DMVTKCX DN POP-1 DMVTKCX MI TT2WR1T DMVTKCX MN Cationic trypsinogen (PRSS1) DMVTKCX MT DTT DMVTKCX MA Modulator DMVTKCX RN US patent application no. 2012,0251,516, PHARMACEUTICAL COMPOSITION FOR TREATING CANCER COMPRISING TRYPSINOGEN AND/OR CHYMOTRYPSINOGEN AND AN ACTIVE AGENT SELECTED FROM A SELENIUM COMPOUND, A VANILLOID COMPOUND AND A CYTOPLASMIC GLYCOLYSIS REDUCTION AGENT. DMVTKCX RU http://www.patentbuddy.com/Patent/20120251516?ft=true&sr=true DMVTKCX DI DMVTKCX DMVTKCX DN POP-1 DMVTKCX MI TT7MRGU DMVTKCX MN Chymotrypsin (CTR) DMVTKCX MT DTT DMVTKCX MA Modulator DMVTKCX RN US patent application no. 2012,0251,516, PHARMACEUTICAL COMPOSITION FOR TREATING CANCER COMPRISING TRYPSINOGEN AND/OR CHYMOTRYPSINOGEN AND AN ACTIVE AGENT SELECTED FROM A SELENIUM COMPOUND, A VANILLOID COMPOUND AND A CYTOPLASMIC GLYCOLYSIS REDUCTION AGENT. DMVTKCX RU http://www.patentbuddy.com/Patent/20120251516?ft=true&sr=true DMQCSFV DI DMQCSFV DMQCSFV DN Porphyran DMQCSFV MI DEF4X7T DMQCSFV MN Beta-porphyranase A (GH86A) DMQCSFV MT DME DMQCSFV MA Metabolism DMQCSFV RN Transfer of carbohydrate-active enzymes from marine bacteria to Japanese gut microbiota. Nature. 2010 Apr 8;464(7290):908-12. DMQCSFV RU https://pubmed.ncbi.nlm.nih.gov/20376150 DMU8KTO DI DMU8KTO DMU8KTO DN PP121 DMU8KTO MI TT6B75U DMU8KTO MN ABL messenger RNA (ABL mRNA) DMU8KTO MT DTT DMU8KTO MA Inhibitor DMU8KTO RN Targeted polypharmacology: discovery of dual inhibitors of tyrosine and phosphoinositide kinases. Nat Chem Biol. 2008 Nov;4(11):691-9. DMU8KTO RU https://pubmed.ncbi.nlm.nih.gov/18849971 DMU8KTO DI DMU8KTO DMU8KTO DN PP121 DMU8KTO MI TTK3PY9 DMU8KTO MN DNA-dependent protein kinase catalytic (PRKDC) DMU8KTO MT DTT DMU8KTO MA Inhibitor DMU8KTO RN Targeted polypharmacology: discovery of dual inhibitors of tyrosine and phosphoinositide kinases. Nat Chem Biol. 2008 Nov;4(11):691-9. DMU8KTO RU https://pubmed.ncbi.nlm.nih.gov/18849971 DMU8KTO DI DMU8KTO DMU8KTO DN PP121 DMU8KTO MI TTGKNB4 DMU8KTO MN Epidermal growth factor receptor (EGFR) DMU8KTO MT DTT DMU8KTO MA Inhibitor DMU8KTO RN Targeted polypharmacology: discovery of dual inhibitors of tyrosine and phosphoinositide kinases. Nat Chem Biol. 2008 Nov;4(11):691-9. DMU8KTO RU https://pubmed.ncbi.nlm.nih.gov/18849971 DMU8KTO DI DMU8KTO DMU8KTO DN PP121 DMU8KTO MI TT42OGM DMU8KTO MN Hematopoietic cell kinase (HCK) DMU8KTO MT DTT DMU8KTO MA Inhibitor DMU8KTO RN Targeted polypharmacology: discovery of dual inhibitors of tyrosine and phosphoinositide kinases. Nat Chem Biol. 2008 Nov;4(11):691-9. DMU8KTO RU https://pubmed.ncbi.nlm.nih.gov/18849971 DMU8KTO DI DMU8KTO DMU8KTO DN PP121 DMU8KTO MI TTTHBCA DMU8KTO MN PI3-kinase beta (PIK3CB) DMU8KTO MT DTT DMU8KTO MA Inhibitor DMU8KTO RN Targeted polypharmacology: discovery of dual inhibitors of tyrosine and phosphoinositide kinases. Nat Chem Biol. 2008 Nov;4(11):691-9. DMU8KTO RU https://pubmed.ncbi.nlm.nih.gov/18849971 DMU8KTO DI DMU8KTO DMU8KTO DN PP121 DMU8KTO MI TTHBTOP DMU8KTO MN PI3-kinase gamma (PIK3CG) DMU8KTO MT DTT DMU8KTO MA Inhibitor DMU8KTO RN Targeted polypharmacology: discovery of dual inhibitors of tyrosine and phosphoinositide kinases. Nat Chem Biol. 2008 Nov;4(11):691-9. DMU8KTO RU https://pubmed.ncbi.nlm.nih.gov/18849971 DMU8KTO DI DMU8KTO DMU8KTO DN PP121 DMU8KTO MI TT8FYO9 DMU8KTO MN Platelet-derived growth factor receptor alpha (PDGFRA) DMU8KTO MT DTT DMU8KTO MA Inhibitor DMU8KTO RN Targeted polypharmacology: discovery of dual inhibitors of tyrosine and phosphoinositide kinases. Nat Chem Biol. 2008 Nov;4(11):691-9. DMU8KTO RU https://pubmed.ncbi.nlm.nih.gov/18849971 DMU8KTO DI DMU8KTO DMU8KTO DN PP121 DMU8KTO MI TT6PKBN DMU8KTO MN Proto-oncogene c-Src (SRC) DMU8KTO MT DTT DMU8KTO MA Inhibitor DMU8KTO RN Targeted polypharmacology: discovery of dual inhibitors of tyrosine and phosphoinositide kinases. Nat Chem Biol. 2008 Nov;4(11):691-9. DMU8KTO RU https://pubmed.ncbi.nlm.nih.gov/18849971 DMU8KTO DI DMU8KTO DMU8KTO DN PP121 DMU8KTO MI TTCJG29 DMU8KTO MN Serine/threonine-protein kinase mTOR (mTOR) DMU8KTO MT DTT DMU8KTO MA Inhibitor DMU8KTO RN Targeted polypharmacology: discovery of dual inhibitors of tyrosine and phosphoinositide kinases. Nat Chem Biol. 2008 Nov;4(11):691-9. DMU8KTO RU https://pubmed.ncbi.nlm.nih.gov/18849971 DMU8KTO DI DMU8KTO DMU8KTO DN PP121 DMU8KTO MI TTUTJGQ DMU8KTO MN Vascular endothelial growth factor receptor 2 (KDR) DMU8KTO MT DTT DMU8KTO MA Inhibitor DMU8KTO RN Targeted polypharmacology: discovery of dual inhibitors of tyrosine and phosphoinositide kinases. Nat Chem Biol. 2008 Nov;4(11):691-9. DMU8KTO RU https://pubmed.ncbi.nlm.nih.gov/18849971 DMYA5CB DI DMYA5CB DMYA5CB DN PP1-Pro-Phe-N-MeHis-LVA-Ile-Amp-(O) DMYA5CB MI TTB2MXP DMYA5CB MN Angiotensinogenase renin (REN) DMYA5CB MT DTT DMYA5CB MA Inhibitor DMYA5CB RN Renin inhibitory peptides. Incorporation of polar, hydrophilic end groups into an active renin inhibitory peptide template and their evaluation in ... J Med Chem. 1991 Feb;34(2):633-42. DMYA5CB RU https://pubmed.ncbi.nlm.nih.gov/1995887 DM2348V DI DM2348V DM2348V DN PP-242 DM2348V MI TTC0V1J DM2348V MN PAS domain-containing serine/threonine-protein kinase (PASK) DM2348V MT DTT DM2348V MA Inhibitor DM2348V RN Targeted polypharmacology: discovery of dual inhibitors of tyrosine and phosphoinositide kinases. Nat Chem Biol. 2008 Nov;4(11):691-9. DM2348V RU https://pubmed.ncbi.nlm.nih.gov/18849971 DM2348V DI DM2348V DM2348V DN PP-242 DM2348V MI TTCJG29 DM2348V MN Serine/threonine-protein kinase mTOR (mTOR) DM2348V MT DTT DM2348V MA Inhibitor DM2348V RN Targeted polypharmacology: discovery of dual inhibitors of tyrosine and phosphoinositide kinases. Nat Chem Biol. 2008 Nov;4(11):691-9. DM2348V RU https://pubmed.ncbi.nlm.nih.gov/18849971 DM3NUKX DI DM3NUKX DM3NUKX DN PP2-Pro-Phe-N-MeHis-LVA-Ile-Amp-(O) DM3NUKX MI TTB2MXP DM3NUKX MN Angiotensinogenase renin (REN) DM3NUKX MT DTT DM3NUKX MA Inhibitor DM3NUKX RN Renin inhibitory peptides. Incorporation of polar, hydrophilic end groups into an active renin inhibitory peptide template and their evaluation in ... J Med Chem. 1991 Feb;34(2):633-42. DM3NUKX RU https://pubmed.ncbi.nlm.nih.gov/1995887 DM86ZL2 DI DM86ZL2 DM86ZL2 DN PPA DM86ZL2 MI TTUJFD0 DM86ZL2 MN Telomerase reverse transcriptase (TERT) DM86ZL2 MT DTT DM86ZL2 MA Inhibitor DM86ZL2 RN Growth arrest, apoptosis, and telomere shortening of Barrett's-associated adenocarcinoma cells by a telomerase inhibitor. Gastroenterology. 2004 May;126(5):1337-46. DM86ZL2 RU https://pubmed.ncbi.nlm.nih.gov/15131795 DMWHN3T DI DMWHN3T DMWHN3T DN PPADS DMWHN3T MI TTA93TL DMWHN3T MN P2Y purinoceptor 1 (P2RY1) DMWHN3T MT DTT DMWHN3T MA Antagonist DMWHN3T RN Quantitation of the P2Y(1) receptor with a high affinity radiolabeled antagonist. Mol Pharmacol. 2002 Nov;62(5):1249-57. DMWHN3T RU https://pubmed.ncbi.nlm.nih.gov/12391289 DMWHN3T DI DMWHN3T DMWHN3T DN PPADS DMWHN3T MI TT1FE3L DMWHN3T MN P2Y purinoceptor 13 (P2RY13) DMWHN3T MT DTT DMWHN3T MA Antagonist DMWHN3T RN Pharmacological characterization of the human P2Y13 receptor. Mol Pharmacol. 2003 Jul;64(1):104-12. DMWHN3T RU https://pubmed.ncbi.nlm.nih.gov/12815166 DMWHN3T DI DMWHN3T DMWHN3T DN PPADS DMWHN3T MI TT24DGP DMWHN3T MN P2Y purinoceptor 4 (P2RY4) DMWHN3T MT DTT DMWHN3T MA Antagonist DMWHN3T RN Development of selective agonists and antagonists of P2Y receptors. Purinergic Signal. 2009 Mar;5(1):75-89. DMWHN3T RU https://pubmed.ncbi.nlm.nih.gov/18600475 DMWVZFK DI DMWVZFK DMWVZFK DN PPAHV DMWVZFK MI TTMI6F5 DMWVZFK MN Transient receptor potential cation channel V1 (TRPV1) DMWVZFK MT DTT DMWVZFK MA Activator DMWVZFK RN Pharmacological differences between the human and rat vanilloid receptor 1 (VR1). Br J Pharmacol. 2001 Mar;132(5):1084-94. DMWVZFK RU https://pubmed.ncbi.nlm.nih.gov/11226139 DM5IG4F DI DM5IG4F DM5IG4F DN PPG DM5IG4F MI TT0I76D DM5IG4F MN Metabotropic glutamate receptor 7 (mGluR7) DM5IG4F MT DTT DM5IG4F MA Agonist DM5IG4F RN Binding of [3H](2S,1'S,2'S)-2-(9-xanthylmethyl)-2-(2'-carboxycyclopropyl) glycine ([3H]LY341495) to cell membranes expressing recombinant human group III metabotropic glutamate receptor subtypes. Naunyn Schmiedebergs Arch Pharmacol. 2000 Dec;362(6):546-54. DM5IG4F RU https://pubmed.ncbi.nlm.nih.gov/11138847 DML72JT DI DML72JT DML72JT DN PPTN DML72JT MI TT72OKI DML72JT MN P2Y purinoceptor 14 (P2RY14) DML72JT MT DTT DML72JT MA Antagonist DML72JT RN A selective high-affinity antagonist of the P2Y14 receptor inhibits UDP-glucose-stimulated chemotaxis of human neutrophils. Mol Pharmacol. 2013 Jul;84(1):41-9. DML72JT RU https://pubmed.ncbi.nlm.nih.gov/23592514 DMXLPO6 DI DMXLPO6 DMXLPO6 DN PQ-1 DMXLPO6 MI TTJ7ATH DMXLPO6 MN Gap junction alpha-8 protein (Cx50) DMXLPO6 MT DTT DMXLPO6 MA Modulator DMXLPO6 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 732). DMXLPO6 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=732 DMVNHTE DI DMVNHTE DMVNHTE DN PQ401 DMVNHTE MI TTQFBMY DMVNHTE MN IGF1R messenger RNA (IGF1R mRNA) DMVNHTE MT DTT DMVNHTE MA Inhibitor DMVNHTE RN Diarylureas are small-molecule inhibitors of insulin-like growth factor I receptor signaling and breast cancer cell growth. Mol Cancer Ther. 2006 Apr;5(4):1079-86. DMVNHTE RU https://pubmed.ncbi.nlm.nih.gov/16648580 DMBCG31 DI DMBCG31 DMBCG31 DN PR-39 DMBCG31 MI DEX542K DMBCG31 MN Dipeptidylpeptidase IV (DPP4) DMBCG31 MT DME DMBCG31 MA Metabolism DMBCG31 RN nan DMBCG31 RU nan DM3XRJT DI DM3XRJT DM3XRJT DN PRAVADOLINE DM3XRJT MI TT6OEDT DM3XRJT MN Cannabinoid receptor 1 (CB1) DM3XRJT MT DTT DM3XRJT MA Inhibitor DM3XRJT RN Morpholinoalkylindenes as antinociceptive agents: Novel cannabinoid receptor agonists, Bioorg. Med. Chem. Lett. 5(4):381-386 (1995). DM3XRJT RU http://www.sciencedirect.com/science/article/pii/0960894X9500040Z DM3XRJT DI DM3XRJT DM3XRJT DN PRAVADOLINE DM3XRJT MI TTMSFAW DM3XRJT MN Cannabinoid receptor 2 (CB2) DM3XRJT MT DTT DM3XRJT MA Inhibitor DM3XRJT RN Morpholinoalkylindenes as antinociceptive agents: Novel cannabinoid receptor agonists, Bioorg. Med. Chem. Lett. 5(4):381-386 (1995). DM3XRJT RU http://www.sciencedirect.com/science/article/pii/0960894X9500040Z DMHEV75 DI DMHEV75 DMHEV75 DN Preclamol DMHEV75 MI TTEX248 DMHEV75 MN Dopamine D2 receptor (D2R) DMHEV75 MT DTT DMHEV75 MA Inhibitor DMHEV75 RN Pre- and postsynaptic dopaminergic activities of indolizidine and quinolizidine derivatives of 3-(3-hydroxyphenyl)-N-(n-propyl)piperidine (3-PPP). ... J Med Chem. 1990 Mar;33(3):1015-22. DMHEV75 RU https://pubmed.ncbi.nlm.nih.gov/1968512 DM2HN4D DI DM2HN4D DM2HN4D DN Predicentrine methiodide DM2HN4D MI TT4H1MQ DM2HN4D MN Neuronal acetylcholine receptor alpha-4 (CHRNA4) DM2HN4D MT DTT DM2HN4D MA Inhibitor DM2HN4D RN Aporphine metho salts as neuronal nicotinic acetylcholine receptor blockers. Bioorg Med Chem. 2007 May 15;15(10):3368-72. DM2HN4D RU https://pubmed.ncbi.nlm.nih.gov/17391965 DM2HN4D DI DM2HN4D DM2HN4D DN Predicentrine methiodide DM2HN4D MI TT5KPZR DM2HN4D MN Neuronal acetylcholine receptor beta-2 (CHRNB2) DM2HN4D MT DTT DM2HN4D MA Inhibitor DM2HN4D RN Aporphine metho salts as neuronal nicotinic acetylcholine receptor blockers. Bioorg Med Chem. 2007 May 15;15(10):3368-72. DM2HN4D RU https://pubmed.ncbi.nlm.nih.gov/17391965 DM0LW7G DI DM0LW7G DM0LW7G DN pregnenolone-16alpha-carbonitrile DM0LW7G MI TT7LCTF DM0LW7G MN Pregnane X receptor (NR1I2) DM0LW7G MT DTT DM0LW7G MA Agonist DM0LW7G RN An orphan nuclear receptor activated by pregnanes defines a novel steroid signaling pathway. Cell. 1998 Jan 9;92(1):73-82. DM0LW7G RU https://pubmed.ncbi.nlm.nih.gov/9489701 DMC4W03 DI DMC4W03 DMC4W03 DN Premafloxacin DMC4W03 MI TTIXTO3 DMC4W03 MN Staphylococcus Topoisomerase IV (Stap-coc parC) DMC4W03 MT DTT DMC4W03 MA Inhibitor DMC4W03 RN Alteration of Escherichia coli topoisomerase IV to novobiocin resistance. Antimicrob Agents Chemother. 2003 Mar;47(3):941-7. DMC4W03 RU https://pubmed.ncbi.nlm.nih.gov/12604525 DMC4W03 DI DMC4W03 DMC4W03 DN Premafloxacin DMC4W03 MI TT1WJCI DMC4W03 MN Streptococcus Topoisomerase IV A (Stre-coc parC) DMC4W03 MT DTT DMC4W03 MA Inhibitor DMC4W03 RN Alteration of Escherichia coli topoisomerase IV to novobiocin resistance. Antimicrob Agents Chemother. 2003 Mar;47(3):941-7. DMC4W03 RU https://pubmed.ncbi.nlm.nih.gov/12604525 DMVOGT4 DI DMVOGT4 DMVOGT4 DN PREMETREXED DMVOGT4 MI TTU6BFZ DMVOGT4 MN Candida Thymidylate synthase (Candi TMP1) DMVOGT4 MT DTT DMVOGT4 MA Inhibitor DMVOGT4 RN Dual inhibitors of thymidylate synthase and dihydrofolate reductase as antitumor agents: design, synthesis, and biological evaluation of classical ... J Med Chem. 2006 Feb 9;49(3):1055-65. DMVOGT4 RU https://pubmed.ncbi.nlm.nih.gov/16451071 DMVOGT4 DI DMVOGT4 DMVOGT4 DN PREMETREXED DMVOGT4 MI TT9SL3Q DMVOGT4 MN Polypeptide deformylase (PDF) DMVOGT4 MT DTT DMVOGT4 MA Inhibitor DMVOGT4 RN Synthesis, antifolate, and antitumor activities of classical and nonclassical 2-amino-4-oxo-5-substituted-pyrrolo[2,3-d]pyrimidines. J Med Chem. 2001 Jun 7;44(12):1993-2003. DMVOGT4 RU https://pubmed.ncbi.nlm.nih.gov/11384244 DMVOGT4 DI DMVOGT4 DMVOGT4 DN PREMETREXED DMVOGT4 MI TTY8Z2E DMVOGT4 MN Proton-coupled folate transporter (SLC46A1) DMVOGT4 MT DTT DMVOGT4 MA Modulator DMVOGT4 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1213). DMVOGT4 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1213 DMV8YHQ DI DMV8YHQ DMV8YHQ DN prenalterol DMV8YHQ MI TTMXGCW DMV8YHQ MN Adrenergic receptor beta-3 (ADRB3) DMV8YHQ MT DTT DMV8YHQ MA Agonist DMV8YHQ RN Beta 1- and beta 2-adrenergic receptor-mediated adenylate cyclase stimulation in nonfailing and failing human ventricular myocardium. Mol Pharmacol. 1989 Mar;35(3):295-303. DMV8YHQ RU https://pubmed.ncbi.nlm.nih.gov/2564629 DM9HSQJ DI DM9HSQJ DM9HSQJ DN Prenyl pyrophosphate analogue DM9HSQJ MI TT7WZIJ DM9HSQJ MN CAAX farnesyltransferase beta (FNTB) DM9HSQJ MT DTT DM9HSQJ MA Inhibitor DM9HSQJ RN Synthesis and evaluation of benzophenone-based photoaffinity labeling analogs of prenyl pyrophosphates containing stable amide linkages, Bioorg. Med. Chem. Lett. 7(16):2125-2130 (1997). DM9HSQJ RU http://www.sciencedirect.com/science/article/pii/S0960894X97003739 DM5P1NZ DI DM5P1NZ DM5P1NZ DN PREUSSOMERIN DM5P1NZ MI TT7WZIJ DM5P1NZ MN CAAX farnesyltransferase beta (FNTB) DM5P1NZ MT DTT DM5P1NZ MA Inhibitor DM5P1NZ RN Ras farnesyltransferase: a new therapeutic target. J Med Chem. 1997 Sep 12;40(19):2971-90. DM5P1NZ RU https://pubmed.ncbi.nlm.nih.gov/9301658 DMLI4RF DI DMLI4RF DMLI4RF DN Prifelone DMLI4RF MI TT8NGED DMLI4RF MN Prostaglandin G/H synthase 1 (COX-1) DMLI4RF MT DTT DMLI4RF MA Inhibitor DMLI4RF RN Designed multiple ligands. An emerging drug discovery paradigm. J Med Chem. 2005 Oct 20;48(21):6523-43. DMLI4RF RU https://pubmed.ncbi.nlm.nih.gov/16220969 DMLI4RF DI DMLI4RF DMLI4RF DN Prifelone DMLI4RF MI TTVKILB DMLI4RF MN Prostaglandin G/H synthase 2 (COX-2) DMLI4RF MT DTT DMLI4RF MA Inhibitor DMLI4RF RN Designed multiple ligands. An emerging drug discovery paradigm. J Med Chem. 2005 Oct 20;48(21):6523-43. DMLI4RF RU https://pubmed.ncbi.nlm.nih.gov/16220969 DMA8GI6 DI DMA8GI6 DMA8GI6 DN Primary alcohol metabolite of celecoxib DMA8GI6 MI TT8NGED DMA8GI6 MN Prostaglandin G/H synthase 1 (COX-1) DMA8GI6 MT DTT DMA8GI6 MA Inhibitor DMA8GI6 RN Diazen-1-ium-1,2-diolated nitric oxide donor ester prodrugs of 5-(4-hydroxymethylphenyl)-1-(4-aminosulfonylphenyl)-3-trifluoromethyl-1H-pyrazole an... Bioorg Med Chem. 2008 Nov 15;16(22):9694-8. DMA8GI6 RU https://pubmed.ncbi.nlm.nih.gov/18930406 DMA8GI6 DI DMA8GI6 DMA8GI6 DN Primary alcohol metabolite of celecoxib DMA8GI6 MI TTVKILB DMA8GI6 MN Prostaglandin G/H synthase 2 (COX-2) DMA8GI6 MT DTT DMA8GI6 MA Inhibitor DMA8GI6 RN Diazen-1-ium-1,2-diolated nitric oxide donor ester prodrugs of 5-(4-hydroxymethylphenyl)-1-(4-aminosulfonylphenyl)-3-trifluoromethyl-1H-pyrazole an... Bioorg Med Chem. 2008 Nov 15;16(22):9694-8. DMA8GI6 RU https://pubmed.ncbi.nlm.nih.gov/18930406 DMTJZQK DI DMTJZQK DMTJZQK DN pristanic acid DMTJZQK MI TTJ584C DMTJZQK MN Peroxisome proliferator-activated receptor alpha (PPARA) DMTJZQK MT DTT DMTJZQK MA Agonist DMTJZQK RN Pristanic acid and phytanic acid: naturally occurring ligands for the nuclear receptor peroxisome proliferator-activated receptor alpha. J Lipid Res. 2000 Nov;41(11):1801-7. DMTJZQK RU https://pubmed.ncbi.nlm.nih.gov/11060349 DMA2SBL DI DMA2SBL DMA2SBL DN PRO-135 DMA2SBL MI TTZQTY2 DMA2SBL MN DMPK messenger RNA (DMPK mRNA) DMA2SBL MT DTT DMA2SBL RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1505). DMA2SBL RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1505 DMARYLK DI DMARYLK DMARYLK DN Prochiral ketones DMARYLK MI DE6N3C5 DMARYLK MN Alcohol dehydrogenase (ADH) DMARYLK MT DME DMARYLK MA Metabolism DMARYLK RN Neutron and X-ray crystal structures of Lactobacillus brevis alcohol dehydrogenase reveal new insights into hydrogen-bonding pathways. Acta Crystallogr F Struct Biol Commun. 2018 Dec 1;74(Pt 12):754-764. DMARYLK RU https://pubmed.ncbi.nlm.nih.gov/30511668 DMTW82E DI DMTW82E DMTW82E DN Procyanidin B-2 3,3'-di-O-gallate DMTW82E MI TTE14XG DMTW82E MN Squalene monooxygenase (SQLE) DMTW82E MT DTT DMTW82E MA Inhibitor DMTW82E RN Ellagitannins and hexahydroxydiphenoyl esters as inhibitors of vertebrate squalene epoxidase. J Nat Prod. 2001 Aug;64(8):1010-4. DMTW82E RU https://pubmed.ncbi.nlm.nih.gov/11520216 DMGIF1L DI DMGIF1L DMGIF1L DN Prodipine DMGIF1L MI TTVG215 DMGIF1L MN Debrisoquine 4-hydroxylase (CYP2D6) DMGIF1L MT DTT DMGIF1L MA Inhibitor DMGIF1L RN Development of a pharmacophore for inhibition of human liver cytochrome P-450 2D6: molecular modeling and inhibition studies. J Med Chem. 1993 Apr 30;36(9):1136-45. DMGIF1L RU https://pubmed.ncbi.nlm.nih.gov/8487254 DMZH0KY DI DMZH0KY DMZH0KY DN Pro-His-Pro-His-Leu-Phe-Val-Tyr DMZH0KY MI TTB2MXP DMZH0KY MN Angiotensinogenase renin (REN) DMZH0KY MT DTT DMZH0KY MA Inhibitor DMZH0KY RN Inhibition of the renin-angiotensin system. A new approach to the therapy of hypertension. J Med Chem. 1981 Apr;24(4):355-61. DMZH0KY RU https://pubmed.ncbi.nlm.nih.gov/6267277 DMD3WVO DI DMD3WVO DMD3WVO DN Pro-His-Pro-His-Phe-Phe-Val-Tyr DMD3WVO MI TTB2MXP DMD3WVO MN Angiotensinogenase renin (REN) DMD3WVO MT DTT DMD3WVO MA Inhibitor DMD3WVO RN Inhibition of the renin-angiotensin system. A new approach to the therapy of hypertension. J Med Chem. 1981 Apr;24(4):355-61. DMD3WVO RU https://pubmed.ncbi.nlm.nih.gov/6267277 DMNDUI3 DI DMNDUI3 DMNDUI3 DN Pro-His-Pro-His-Phe-Phe-Val-Tyr-Lys DMNDUI3 MI TTB2MXP DMNDUI3 MN Angiotensinogenase renin (REN) DMNDUI3 MT DTT DMNDUI3 MA Inhibitor DMNDUI3 RN Inhibition of the renin-angiotensin system. A new approach to the therapy of hypertension. J Med Chem. 1981 Apr;24(4):355-61. DMNDUI3 RU https://pubmed.ncbi.nlm.nih.gov/6267277 DM26VFX DI DM26VFX DM26VFX DN Pro-His-Pro-Phe-His-Leu(CH2NH)Val-Ile-His-Lys DM26VFX MI TTB2MXP DM26VFX MN Angiotensinogenase renin (REN) DM26VFX MT DTT DM26VFX MA Inhibitor DM26VFX RN Synthesis and biological activity of some transition-state inhibitors of human renin. J Med Chem. 1988 Sep;31(9):1839-46. DM26VFX RU https://pubmed.ncbi.nlm.nih.gov/3137345 DM82TMA DI DM82TMA DM82TMA DN Proline DM82TMA MI DEVJIHS DM82TMA MN Proline dehydrogenase 1 (PRODH) DM82TMA MT DME DM82TMA MA Metabolism DM82TMA RN Proline metabolism and microenvironmental stress. Annu Rev Nutr. 2010 Aug 21;30:441-63. DM82TMA RU https://www.ncbi.nlm.nih.gov/pubmed/?term=20415579 DMOTXE3 DI DMOTXE3 DMOTXE3 DN Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2 DMOTXE3 MI TTZPO1L DMOTXE3 MN Substance-P receptor (TACR1) DMOTXE3 MT DTT DMOTXE3 MA Inhibitor DMOTXE3 RN Conformational comparisons of a series of tachykinin peptide analogs. J Med Chem. 2007 Dec 27;50(26):6501-6. DMOTXE3 RU https://pubmed.ncbi.nlm.nih.gov/18067242 DMY3VGC DI DMY3VGC DMY3VGC DN Promethazine DMY3VGC MI TTAIY2U DMY3VGC MN HUMAN clathrin-mediated endocytosis (RME) DMY3VGC MT DTT DMY3VGC MA Inhibitor DMY3VGC RN Therapeutic options for the 2019 novel coronavirus (2019-nCoV). Nat Rev Drug Discov. 2020 Mar;19(3):149-150. DMY3VGC RU https://pubmed.ncbi.nlm.nih.gov/32127666 DMIUV25 DI DMIUV25 DMIUV25 DN PRONTOCIL DMIUV25 MI TTUNARX DMIUV25 MN Carbonic anhydrase (CA) DMIUV25 MT DTT DMIUV25 MA Inhibitor DMIUV25 RN Carbonic anhydrase inhibitors: cloning, characterization, and inhibition studies of the cytosolic isozyme III with sulfonamides. Bioorg Med Chem. 2007 Dec 1;15(23):7229-36. DMIUV25 RU https://pubmed.ncbi.nlm.nih.gov/17826101 DMIUV25 DI DMIUV25 DMIUV25 DN PRONTOCIL DMIUV25 MI TTANPDJ DMIUV25 MN Carbonic anhydrase II (CA-II) DMIUV25 MT DTT DMIUV25 MA Inhibitor DMIUV25 RN Carbonic anhydrase inhibitors. Inhibition of the Rv1284 and Rv3273 beta-carbonic anhydrases from Mycobacterium tuberculosis with diazenylbenzenesul... Bioorg Med Chem Lett. 2009 Sep 1;19(17):4929-32. DMIUV25 RU https://pubmed.ncbi.nlm.nih.gov/19651511 DMGA53N DI DMGA53N DMGA53N DN Prontosil DMGA53N MI DEUGFHC DMGA53N MN Azoreductase (azoR) DMGA53N MT DME DMGA53N MA Metabolism DMGA53N RN Intestinal azo-reduction and glucuronide conjugation of prontosil. Xenobiotica. 1973 Sep;3(9):599-604. DMGA53N RU https://pubmed.ncbi.nlm.nih.gov/4763145 DM8O41M DI DM8O41M DM8O41M DN Prop-2-ynyl 4-sulfamoylbenzoate DM8O41M MI TTHQPL7 DM8O41M MN Carbonic anhydrase I (CA-I) DM8O41M MT DTT DM8O41M MA Inhibitor DM8O41M RN A novel class of carbonic anhydrase inhibitors: glycoconjugate benzene sulfonamides prepared by "click-tailing". J Med Chem. 2006 Nov 2;49(22):6539-48. DM8O41M RU https://pubmed.ncbi.nlm.nih.gov/17064072 DM8O41M DI DM8O41M DM8O41M DN Prop-2-ynyl 4-sulfamoylbenzoate DM8O41M MI TTANPDJ DM8O41M MN Carbonic anhydrase II (CA-II) DM8O41M MT DTT DM8O41M MA Inhibitor DM8O41M RN A novel class of carbonic anhydrase inhibitors: glycoconjugate benzene sulfonamides prepared by "click-tailing". J Med Chem. 2006 Nov 2;49(22):6539-48. DM8O41M RU https://pubmed.ncbi.nlm.nih.gov/17064072 DM8O41M DI DM8O41M DM8O41M DN Prop-2-ynyl 4-sulfamoylbenzoate DM8O41M MI TT2LVK8 DM8O41M MN Carbonic anhydrase IX (CA-IX) DM8O41M MT DTT DM8O41M MA Inhibitor DM8O41M RN A novel class of carbonic anhydrase inhibitors: glycoconjugate benzene sulfonamides prepared by "click-tailing". J Med Chem. 2006 Nov 2;49(22):6539-48. DM8O41M RU https://pubmed.ncbi.nlm.nih.gov/17064072 DM8O41M DI DM8O41M DM8O41M DN Prop-2-ynyl 4-sulfamoylbenzoate DM8O41M MI TTSYM0R DM8O41M MN Carbonic anhydrase XII (CA-XII) DM8O41M MT DTT DM8O41M MA Inhibitor DM8O41M RN Inhibition of membrane-associated carbonic anhydrase isozymes IX, XII and XIV with a library of glycoconjugate benzenesulfonamides. Bioorg Med Chem Lett. 2007 Feb 15;17(4):987-92. DM8O41M RU https://pubmed.ncbi.nlm.nih.gov/17157501 DM8O41M DI DM8O41M DM8O41M DN Prop-2-ynyl 4-sulfamoylbenzoate DM8O41M MI TTEYTKG DM8O41M MN Carbonic anhydrase XIV (CA-XIV) DM8O41M MT DTT DM8O41M MA Inhibitor DM8O41M RN Inhibition of membrane-associated carbonic anhydrase isozymes IX, XII and XIV with a library of glycoconjugate benzenesulfonamides. Bioorg Med Chem Lett. 2007 Feb 15;17(4):987-92. DM8O41M RU https://pubmed.ncbi.nlm.nih.gov/17157501 DMQZYW6 DI DMQZYW6 DMQZYW6 DN Propan-2-one O-3-butoxyphenylcarbamoyl oxime DMQZYW6 MI TTDP1UC DMQZYW6 MN Fatty acid amide hydrolase (FAAH) DMQZYW6 MT DTT DMQZYW6 MA Inhibitor DMQZYW6 RN Oxime carbamate--discovery of a series of novel FAAH inhibitors. Bioorg Med Chem Lett. 2010 Feb 1;20(3):1272-7. DMQZYW6 RU https://pubmed.ncbi.nlm.nih.gov/20036536 DMIQ0DF DI DMIQ0DF DMIQ0DF DN Propan-2-one O-4-(decyloxy)phenylcarbamoyl oxime DMIQ0DF MI TTDP1UC DMIQ0DF MN Fatty acid amide hydrolase (FAAH) DMIQ0DF MT DTT DMIQ0DF MA Inhibitor DMIQ0DF RN Oxime carbamate--discovery of a series of novel FAAH inhibitors. Bioorg Med Chem Lett. 2010 Feb 1;20(3):1272-7. DMIQ0DF RU https://pubmed.ncbi.nlm.nih.gov/20036536 DM8FXM6 DI DM8FXM6 DM8FXM6 DN Propan-2-one O-4-(heptyloxy)phenylcarbamoyl oxime DM8FXM6 MI TTDP1UC DM8FXM6 MN Fatty acid amide hydrolase (FAAH) DM8FXM6 MT DTT DM8FXM6 MA Inhibitor DM8FXM6 RN Oxime carbamate--discovery of a series of novel FAAH inhibitors. Bioorg Med Chem Lett. 2010 Feb 1;20(3):1272-7. DM8FXM6 RU https://pubmed.ncbi.nlm.nih.gov/20036536 DM5J0H3 DI DM5J0H3 DM5J0H3 DN Propan-2-one O-4-(hexyloxy)phenylcarbamoyl oxime DM5J0H3 MI TTDP1UC DM5J0H3 MN Fatty acid amide hydrolase (FAAH) DM5J0H3 MT DTT DM5J0H3 MA Inhibitor DM5J0H3 RN Oxime carbamate--discovery of a series of novel FAAH inhibitors. Bioorg Med Chem Lett. 2010 Feb 1;20(3):1272-7. DM5J0H3 RU https://pubmed.ncbi.nlm.nih.gov/20036536 DMYBH91 DI DMYBH91 DMYBH91 DN Propan-2-one O-4-(nonyloxy)phenylcarbamoyl oxime DMYBH91 MI TTDP1UC DMYBH91 MN Fatty acid amide hydrolase (FAAH) DMYBH91 MT DTT DMYBH91 MA Inhibitor DMYBH91 RN Oxime carbamate--discovery of a series of novel FAAH inhibitors. Bioorg Med Chem Lett. 2010 Feb 1;20(3):1272-7. DMYBH91 RU https://pubmed.ncbi.nlm.nih.gov/20036536 DM6VZ4S DI DM6VZ4S DM6VZ4S DN Propan-2-one O-4-(octyloxy)phenylcarbamoyl oxime DM6VZ4S MI TTDP1UC DM6VZ4S MN Fatty acid amide hydrolase (FAAH) DM6VZ4S MT DTT DM6VZ4S MA Inhibitor DM6VZ4S RN Oxime carbamate--discovery of a series of novel FAAH inhibitors. Bioorg Med Chem Lett. 2010 Feb 1;20(3):1272-7. DM6VZ4S RU https://pubmed.ncbi.nlm.nih.gov/20036536 DM408U3 DI DM408U3 DM408U3 DN Propan-2-one O-4-(pentyloxy)phenylcarbamoyl oxime DM408U3 MI TTDP1UC DM408U3 MN Fatty acid amide hydrolase (FAAH) DM408U3 MT DTT DM408U3 MA Inhibitor DM408U3 RN Oxime carbamate--discovery of a series of novel FAAH inhibitors. Bioorg Med Chem Lett. 2010 Feb 1;20(3):1272-7. DM408U3 RU https://pubmed.ncbi.nlm.nih.gov/20036536 DMV13MO DI DMV13MO DMV13MO DN Propan-2-one O-4-butoxybenzylcarbamoyl oxime DMV13MO MI TTDP1UC DMV13MO MN Fatty acid amide hydrolase (FAAH) DMV13MO MT DTT DMV13MO MA Inhibitor DMV13MO RN Oxime carbamate--discovery of a series of novel FAAH inhibitors. Bioorg Med Chem Lett. 2010 Feb 1;20(3):1272-7. DMV13MO RU https://pubmed.ncbi.nlm.nih.gov/20036536 DMYJ28G DI DMYJ28G DMYJ28G DN Propan-2-one O-4-butoxyphenylcarbamoyl oxime DMYJ28G MI TTDP1UC DMYJ28G MN Fatty acid amide hydrolase (FAAH) DMYJ28G MT DTT DMYJ28G MA Inhibitor DMYJ28G RN Oxime carbamate--discovery of a series of novel FAAH inhibitors. Bioorg Med Chem Lett. 2010 Feb 1;20(3):1272-7. DMYJ28G RU https://pubmed.ncbi.nlm.nih.gov/20036536 DM573UT DI DM573UT DM573UT DN Propan-2-one O-4-ethoxyphenylcarbamoyl oxime DM573UT MI TTDP1UC DM573UT MN Fatty acid amide hydrolase (FAAH) DM573UT MT DTT DM573UT MA Inhibitor DM573UT RN Oxime carbamate--discovery of a series of novel FAAH inhibitors. Bioorg Med Chem Lett. 2010 Feb 1;20(3):1272-7. DM573UT RU https://pubmed.ncbi.nlm.nih.gov/20036536 DMWX5Q6 DI DMWX5Q6 DMWX5Q6 DN Propan-2-one O-4-propoxyphenylcarbamoyl oxime DMWX5Q6 MI TTDP1UC DMWX5Q6 MN Fatty acid amide hydrolase (FAAH) DMWX5Q6 MT DTT DMWX5Q6 MA Inhibitor DMWX5Q6 RN Oxime carbamate--discovery of a series of novel FAAH inhibitors. Bioorg Med Chem Lett. 2010 Feb 1;20(3):1272-7. DMWX5Q6 RU https://pubmed.ncbi.nlm.nih.gov/20036536 DMQ9USH DI DMQ9USH DMQ9USH DN Propandiamine DMQ9USH MI DEMWO83 DMQ9USH MN Putrescine acetyltransferase (SSAT1) DMQ9USH MT DME DMQ9USH MA Metabolism DMQ9USH RN Mechanistic and structural analysis of human spermidine/spermine N1-acetyltransferase. Biochemistry. 2007 Jun 19;46(24):7187-95. DMQ9USH RU https://www.ncbi.nlm.nih.gov/pubmed/?term=17516632 DM9TN2W DI DM9TN2W DM9TN2W DN Propanoic Acid DM9TN2W MI TT6TMZU DM9TN2W MN Mycobacterium Biosynthetic alanine racemase (MycB alr) DM9TN2W MT DTT DM9TN2W MA Inhibitor DM9TN2W RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DM9TN2W RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMVRWL6 DI DMVRWL6 DMVRWL6 DN propargylglycine DMVRWL6 MI TTLQUZS DMVRWL6 MN Cystathionine gamma-lyase (CTH) DMVRWL6 MT DTT DMVRWL6 MA Inhibitor DMVRWL6 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1444). DMVRWL6 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1444 DMZ1FRS DI DMZ1FRS DMZ1FRS DN Propidium DMZ1FRS MI TT1RS9F DMZ1FRS MN Acetylcholinesterase (AChE) DMZ1FRS MT DTT DMZ1FRS MA Inhibitor DMZ1FRS RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMZ1FRS RU https://pubmed.ncbi.nlm.nih.gov/17139284 DM0O8N6 DI DM0O8N6 DM0O8N6 DN Propionate DM0O8N6 MI TT6TMZU DM0O8N6 MN Mycobacterium Biosynthetic alanine racemase (MycB alr) DM0O8N6 MT DTT DM0O8N6 MA Inhibitor DM0O8N6 RN Molecular dynamics studies of alanine racemase: a structural model for drug design. Biopolymers. 2003 Oct;70(2):186-200. DM0O8N6 RU https://pubmed.ncbi.nlm.nih.gov/14517907 DM0O8N6 DI DM0O8N6 DM0O8N6 DN Propionate DM0O8N6 MI DTE3TAW DM0O8N6 MN Sodium-coupled monocarboxylate transporter 1 (SLC5A8) DM0O8N6 MT DTP DM0O8N6 MA Substrate DM0O8N6 RN SLC transporters as a novel class of tumour suppressors: identity, function and molecular mechanisms. Biochem J. 2016 May 1;473(9):1113-24. DM0O8N6 RU http://www.ncbi.nlm.nih.gov/pubmed/27118869 DMO325J DI DMO325J DMO325J DN Propionic acid 8-aza-bicyclo[3.2.1]oct-6-yl ester DMO325J MI TTZ9SOR DMO325J MN Muscarinic acetylcholine receptor M1 (CHRM1) DMO325J MT DTT DMO325J MA Inhibitor DMO325J RN 6beta-Acyloxy(nor)tropanes: affinities for antagonist/agonist binding sites on transfected and native muscarinic receptors. J Med Chem. 2000 Jun 29;43(13):2514-22. DMO325J RU https://pubmed.ncbi.nlm.nih.gov/10891110 DMO325J DI DMO325J DMO325J DN Propionic acid 8-aza-bicyclo[3.2.1]oct-6-yl ester DMO325J MI TTYEG6Q DMO325J MN Muscarinic acetylcholine receptor M2 (CHRM2) DMO325J MT DTT DMO325J MA Inhibitor DMO325J RN 6beta-Acyloxy(nor)tropanes: affinities for antagonist/agonist binding sites on transfected and native muscarinic receptors. J Med Chem. 2000 Jun 29;43(13):2514-22. DMO325J RU https://pubmed.ncbi.nlm.nih.gov/10891110 DMO325J DI DMO325J DMO325J DN Propionic acid 8-aza-bicyclo[3.2.1]oct-6-yl ester DMO325J MI TTQ13Z5 DMO325J MN Muscarinic acetylcholine receptor M3 (CHRM3) DMO325J MT DTT DMO325J MA Inhibitor DMO325J RN 6beta-Acyloxy(nor)tropanes: affinities for antagonist/agonist binding sites on transfected and native muscarinic receptors. J Med Chem. 2000 Jun 29;43(13):2514-22. DMO325J RU https://pubmed.ncbi.nlm.nih.gov/10891110 DMO325J DI DMO325J DMO325J DN Propionic acid 8-aza-bicyclo[3.2.1]oct-6-yl ester DMO325J MI TTQ3JTF DMO325J MN Muscarinic acetylcholine receptor M4 (CHRM4) DMO325J MT DTT DMO325J MA Inhibitor DMO325J RN 6beta-Acyloxy(nor)tropanes: affinities for antagonist/agonist binding sites on transfected and native muscarinic receptors. J Med Chem. 2000 Jun 29;43(13):2514-22. DMO325J RU https://pubmed.ncbi.nlm.nih.gov/10891110 DMZ40RQ DI DMZ40RQ DMZ40RQ DN Propyl-(4,5,6,7-tetrahydro-2H-indazol-5-yl)-amine DMZ40RQ MI TTEX248 DMZ40RQ MN Dopamine D2 receptor (D2R) DMZ40RQ MT DTT DMZ40RQ MA Inhibitor DMZ40RQ RN Substituted 5-amino-4,5,6,7-tetrahydroindazoles as partial ergoline structures with dopaminergic activity. J Med Chem. 1989 Oct;32(10):2388-96. DMZ40RQ RU https://pubmed.ncbi.nlm.nih.gov/2571732 DMTCP8K DI DMTCP8K DMTCP8K DN propylpyrazoletriol DMTCP8K MI TTZAYWL DMTCP8K MN Estrogen receptor (ESR) DMTCP8K MT DTT DMTCP8K MA Agonist DMTCP8K RN Conformational changes and coactivator recruitment by novel ligands for estrogen receptor-alpha and estrogen receptor-beta: correlations with biological character and distinct differences among SRC coactivator family members. Endocrinology. 2000 Oct;141(10):3534-45. DMTCP8K RU https://pubmed.ncbi.nlm.nih.gov/11014206 DMXCJ7O DI DMXCJ7O DMXCJ7O DN Prostacyclin analog DMXCJ7O MI TTOFYT1 DMXCJ7O MN Prostacyclin receptor (PTGIR) DMXCJ7O MT DTT DMXCJ7O MA Modulator DMXCJ7O RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 345). DMXCJ7O RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=345 DMWC4X8 DI DMWC4X8 DMWC4X8 DN Prostaglandin A2 DMWC4X8 MI DTUGYRD DMWC4X8 MN P-glycoprotein 1 (ABCB1) DMWC4X8 MT DTP DMWC4X8 MA Substrate DMWC4X8 RN Unveiling the role of multidrug resistance proteins in hypertension. Hypertension. 2009 Aug;54(2):210-6. DMWC4X8 RU https://doi.org/10.1161/HYPERTENSIONAHA.109.129742 DMWC4X8 DI DMWC4X8 DMWC4X8 DN Prostaglandin A2 DMWC4X8 MI TTELV3W DMWC4X8 MN Transformation-sensitive protein p120 (TRPA1) DMWC4X8 MT DTT DMWC4X8 MA Activator DMWC4X8 RN Cox-dependent fatty acid metabolites cause pain through activation of the irritant receptor TRPA1. Proc Natl Acad Sci U S A. 2008 Aug 19;105(33):12045-50. DMWC4X8 RU https://pubmed.ncbi.nlm.nih.gov/18687886 DME74SP DI DME74SP DME74SP DN Prostaglandin G2 DME74SP MI TTVKILB DME74SP MN Prostaglandin G/H synthase 2 (COX-2) DME74SP MT DTT DME74SP MA Inhibitor DME74SP RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DME74SP RU https://pubmed.ncbi.nlm.nih.gov/10592235 DM9GFOM DI DM9GFOM DM9GFOM DN ProstaRex DM9GFOM MI TTS78AZ DM9GFOM MN Prostate specific antigen (KLK3) DM9GFOM MT DTT DM9GFOM MA Modulator DM9GFOM RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2373). DM9GFOM RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2373 DMI8SH2 DI DMI8SH2 DMI8SH2 DN PROSTEPHABYSSINE DMI8SH2 MI TT27RFC DMI8SH2 MN Opioid receptor delta (OPRD1) DMI8SH2 MT DTT DMI8SH2 MA Inhibitor DMI8SH2 RN Hasubanan alkaloids with delta-opioid binding affinity from the aerial parts of Stephania japonica. J Nat Prod. 2010 May 28;73(5):988-91. DMI8SH2 RU https://pubmed.ncbi.nlm.nih.gov/20426456 DM1HMJ5 DI DM1HMJ5 DM1HMJ5 DN PROSTRATIN DM1HMJ5 MI TT7A1BO DM1HMJ5 MN PKC-delta messenger RNA (PRKCD mRNA) DM1HMJ5 MT DTT DM1HMJ5 MA Inhibitor DM1HMJ5 RN A nonpromoting phorbol from the samoan medicinal plant Homalanthus nutans inhibits cell killing by HIV-1. J Med Chem. 1992 May 29;35(11):1978-86. DM1HMJ5 RU https://pubmed.ncbi.nlm.nih.gov/1597853 DM1HMJ5 DI DM1HMJ5 DM1HMJ5 DN PROSTRATIN DM1HMJ5 MI TT57MT2 DM1HMJ5 MN PKC-epsilon messenger RNA (PRKCE mRNA) DM1HMJ5 MT DTT DM1HMJ5 MA Inhibitor DM1HMJ5 RN A nonpromoting phorbol from the samoan medicinal plant Homalanthus nutans inhibits cell killing by HIV-1. J Med Chem. 1992 May 29;35(11):1978-86. DM1HMJ5 RU https://pubmed.ncbi.nlm.nih.gov/1597853 DM1HMJ5 DI DM1HMJ5 DM1HMJ5 DN PROSTRATIN DM1HMJ5 MI TTONI0R DM1HMJ5 MN PKC-eta messenger RNA (PRKCH mRNA) DM1HMJ5 MT DTT DM1HMJ5 MA Inhibitor DM1HMJ5 RN A nonpromoting phorbol from the samoan medicinal plant Homalanthus nutans inhibits cell killing by HIV-1. J Med Chem. 1992 May 29;35(11):1978-86. DM1HMJ5 RU https://pubmed.ncbi.nlm.nih.gov/1597853 DM1HMJ5 DI DM1HMJ5 DM1HMJ5 DN PROSTRATIN DM1HMJ5 MI TT1MS7X DM1HMJ5 MN PKC-theta messenger RNA (PRKCQ mRNA) DM1HMJ5 MT DTT DM1HMJ5 MA Inhibitor DM1HMJ5 RN A nonpromoting phorbol from the samoan medicinal plant Homalanthus nutans inhibits cell killing by HIV-1. J Med Chem. 1992 May 29;35(11):1978-86. DM1HMJ5 RU https://pubmed.ncbi.nlm.nih.gov/1597853 DM1HMJ5 DI DM1HMJ5 DM1HMJ5 DN PROSTRATIN DM1HMJ5 MI TTFJ8Q1 DM1HMJ5 MN Protein kinase C alpha (PRKCA) DM1HMJ5 MT DTT DM1HMJ5 MA Inhibitor DM1HMJ5 RN A nonpromoting phorbol from the samoan medicinal plant Homalanthus nutans inhibits cell killing by HIV-1. J Med Chem. 1992 May 29;35(11):1978-86. DM1HMJ5 RU https://pubmed.ncbi.nlm.nih.gov/1597853 DM1HMJ5 DI DM1HMJ5 DM1HMJ5 DN PROSTRATIN DM1HMJ5 MI TTYPXQF DM1HMJ5 MN Protein kinase C beta (PRKCB) DM1HMJ5 MT DTT DM1HMJ5 MA Inhibitor DM1HMJ5 RN A nonpromoting phorbol from the samoan medicinal plant Homalanthus nutans inhibits cell killing by HIV-1. J Med Chem. 1992 May 29;35(11):1978-86. DM1HMJ5 RU https://pubmed.ncbi.nlm.nih.gov/1597853 DM1HMJ5 DI DM1HMJ5 DM1HMJ5 DN PROSTRATIN DM1HMJ5 MI TT9WJ8U DM1HMJ5 MN Protein kinase C delta (PRKCD) DM1HMJ5 MT DTT DM1HMJ5 MA Inhibitor DM1HMJ5 RN A nonpromoting phorbol from the samoan medicinal plant Homalanthus nutans inhibits cell killing by HIV-1. J Med Chem. 1992 May 29;35(11):1978-86. DM1HMJ5 RU https://pubmed.ncbi.nlm.nih.gov/1597853 DM1HMJ5 DI DM1HMJ5 DM1HMJ5 DN PROSTRATIN DM1HMJ5 MI TTRFOXJ DM1HMJ5 MN Protein kinase C gamma (PRKCG) DM1HMJ5 MT DTT DM1HMJ5 MA Inhibitor DM1HMJ5 RN A nonpromoting phorbol from the samoan medicinal plant Homalanthus nutans inhibits cell killing by HIV-1. J Med Chem. 1992 May 29;35(11):1978-86. DM1HMJ5 RU https://pubmed.ncbi.nlm.nih.gov/1597853 DMWYE7A DI DMWYE7A DMWYE7A DN Protoporphyrin IX DMWYE7A MI DTI7UX6 DMWYE7A MN Breast cancer resistance protein (ABCG2) DMWYE7A MT DTP DMWYE7A MA Substrate DMWYE7A RN Pharmacogenomic importance of ABCG2. Pharmacogenomics. 2008 Aug;9(8):1005-9. DMWYE7A RU https://doi.org/10.2217/14622416.9.8.1005 DMWYE7A DI DMWYE7A DMWYE7A DN Protoporphyrin IX DMWYE7A MI TTCYE56 DMWYE7A MN Glutathione-dependent PGD synthase (HPGDS) DMWYE7A MT DTT DMWYE7A MA Inhibitor DMWYE7A RN Inhibition of glutathione-S-transferase from Plasmodium yoelii by protoporphyrin IX, cibacron blue and menadione: implications and therapeutic bene... Parasitol Res. 2008 Mar;102(4):805-7. DMWYE7A RU https://pubmed.ncbi.nlm.nih.gov/18180958 DMJ8TP3 DI DMJ8TP3 DMJ8TP3 DN Protoporphyrin Ix Containing Co DMJ8TP3 MI TT8NGED DMJ8TP3 MN Prostaglandin G/H synthase 1 (COX-1) DMJ8TP3 MT DTT DMJ8TP3 MA Inhibitor DMJ8TP3 RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMJ8TP3 RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMI6TKU DI DMI6TKU DMI6TKU DN PROTOSTEMODIOL DMI6TKU MI TTJSZTB DMI6TKU MN Nicotinic acetylcholine receptor (nAChR) DMI6TKU MT DTT DMI6TKU MA Inhibitor DMI6TKU RN Alkaloids from stems and leaves of Stemona japonica and their insecticidal activities. J Nat Prod. 2008 Jan;71(1):112-6. DMI6TKU RU https://pubmed.ncbi.nlm.nih.gov/18163592 DM43ABN DI DM43ABN DM43ABN DN Provitamin D3 DM43ABN MI DE28NZ9 DM43ABN MN Cytochrome P450 124 (cyp124) DM43ABN MT DME DM43ABN MA Metabolism DM43ABN RN Identification of Mycobacterium tuberculosis enzyme involved in vitamin D and 7-dehydrocholesterol metabolism. J Steroid Biochem Mol Biol. 2017 May;169:202-209. DM43ABN RU https://pubmed.ncbi.nlm.nih.gov/27289046 DM72AT8 DI DM72AT8 DM72AT8 DN Proxyfan DM72AT8 MI TT9JNIC DM72AT8 MN Histamine H3 receptor (H3R) DM72AT8 MT DTT DM72AT8 MA Antagonist DM72AT8 RN The histamine H3 receptor: from gene cloning to H3 receptor drugs. Nat Rev Drug Discov. 2005 Feb;4(2):107-20. DM72AT8 RU https://pubmed.ncbi.nlm.nih.gov/15665857 DMKRMSP DI DMKRMSP DMKRMSP DN Pr-RYYRIK-NH2 DMKRMSP MI TTNT7K8 DMKRMSP MN Nociceptin receptor (OPRL1) DMKRMSP MT DTT DMKRMSP MA Inhibitor DMKRMSP RN Designed modification of partial agonist of ORL1 nociceptin receptor for conversion into highly potent antagonist. Bioorg Med Chem. 2008 Mar 1;16(5):2635-44. DMKRMSP RU https://pubmed.ncbi.nlm.nih.gov/18068993 DM8GCHX DI DM8GCHX DM8GCHX DN PRS-060 DM8GCHX MI TTDWHC3 DM8GCHX MN Interleukin 4 receptor alpha (IL4R) DM8GCHX MT DTT DM8GCHX MA Inhibitor DM8GCHX RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1697). DM8GCHX RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1697 DMB923H DI DMB923H DMB923H DN PRS-110 DMB923H MI TTNDSF4 DMB923H MN Proto-oncogene c-Met (MET) DMB923H MT DTT DMB923H MA Inhibitor DMB923H RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1815). DMB923H RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1815 DM25EDB DI DM25EDB DM25EDB DN PRT-060096 DM25EDB MI TTZ1DT0 DM25EDB MN P2Y purinoceptor 12 (P2RY12) DM25EDB MT DTT DM25EDB MA Antagonist DM25EDB RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 328). DM25EDB RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=328 DMQPEA7 DI DMQPEA7 DMQPEA7 DN PRT-060318 DMQPEA7 MI TTOU65C DMQPEA7 MN Tyrosine-protein kinase SYK (SYK) DMQPEA7 MT DTT DMQPEA7 MA Inhibitor DMQPEA7 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2230). DMQPEA7 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2230 DMOVE31 DI DMOVE31 DMOVE31 DN PRT-064445 DMOVE31 MI TTCIHJA DMOVE31 MN Coagulation factor Xa (F10) DMOVE31 MT DTT DMOVE31 MA Inhibitor DMOVE31 RN Semuloparin for the prevention of venous thromboembolic events in cancer patients. Drugs Today (Barc). 2012 Jul;48(7):451-7. DMOVE31 RU https://pubmed.ncbi.nlm.nih.gov/22844656 DMPD41Q DI DMPD41Q DMPD41Q DN prunetin DMPD41Q MI TTFLN4T DMPD41Q MN Mitochondrial aldehyde dehydrogenase (ALDH2) DMPD41Q MT DTT DMPD41Q MA Inhibitor DMPD41Q RN Structure of daidzin, a naturally occurring anti-alcohol-addiction agent, in complex with human mitochondrial aldehyde dehydrogenase. J Med Chem. 2008 Aug 14;51(15):4482-7. DMPD41Q RU https://pubmed.ncbi.nlm.nih.gov/18613661 DMSPH30 DI DMSPH30 DMSPH30 DN PRX-111 DMSPH30 MI TTZFDBT DMSPH30 MN Follicle-stimulating hormone receptor (FSHR) DMSPH30 MT DTT DMSPH30 MA Modulator DMSPH30 RN A naturally occurring basically charged human follicle-stimulating hormone (FSH) variant inhibits FSH-induced androgen aromatization and tissue-type plasminogen activator enzyme activity in vitro. Neuroendocrinology. 1998 Mar;67(3):153-63. DMSPH30 RU https://pubmed.ncbi.nlm.nih.gov/9630432 DMK6HMS DI DMK6HMS DMK6HMS DN PS020990 DMK6HMS MI TTGY8IW DMK6HMS MN B2 bradykinin receptor (BDKRB2) DMK6HMS MT DTT DMK6HMS MA Antagonist DMK6HMS RN Small molecule antagonists of the bradykinin B1 receptor. Immunopharmacology. 1999 Sep;43(2-3):169-77. DMK6HMS RU https://pubmed.ncbi.nlm.nih.gov/10596850 DMVUMWZ DI DMVUMWZ DMVUMWZ DN PS-1145 DMVUMWZ MI TTRPDBG DMVUMWZ MN Inhibitor of nuclear factor kappa-B kinase (IKK) DMVUMWZ MT DTT DMVUMWZ MA Inhibitor DMVUMWZ RN Emerging therapies for multiple myeloma. Expert Opin Emerg Drugs. 2009 Mar;14(1):99-127. DMVUMWZ RU https://pubmed.ncbi.nlm.nih.gov/19249983 DMVUMWZ DI DMVUMWZ DMVUMWZ DN PS-1145 DMVUMWZ MI TTSXVID DMVUMWZ MN Nuclear factor NF-kappa-B (NFKB) DMVUMWZ MT DTT DMVUMWZ MA Activator DMVUMWZ RN Emerging therapies for multiple myeloma. Expert Opin Emerg Drugs. 2009 Mar;14(1):99-127. DMVUMWZ RU https://pubmed.ncbi.nlm.nih.gov/19249983 DMQUG0K DI DMQUG0K DMQUG0K DN PS-154636-1 DMQUG0K MI TTXMNHO DMQUG0K MN Plasmodium Plasmepsin 2 (Malaria PLA2) DMQUG0K MT DTT DMQUG0K MA Inhibitor DMQUG0K RN Identification of potent inhibitors of Plasmodium falciparum plasmepsin II from an encoded statine combinatorial library. Bioorg Med Chem Lett. 1998 Sep 8;8(17):2315-20. DMQUG0K RU https://pubmed.ncbi.nlm.nih.gov/9873534 DMQVI5U DI DMQVI5U DMQVI5U DN PS-222036 DMQVI5U MI TTXMNHO DMQVI5U MN Plasmodium Plasmepsin 2 (Malaria PLA2) DMQVI5U MT DTT DMQVI5U MA Inhibitor DMQVI5U RN Identification of potent inhibitors of Plasmodium falciparum plasmepsin II from an encoded statine combinatorial library. Bioorg Med Chem Lett. 1998 Sep 8;8(17):2315-20. DMQVI5U RU https://pubmed.ncbi.nlm.nih.gov/9873534 DMH8YMP DI DMH8YMP DMH8YMP DN PS-444035 DMH8YMP MI TTXMNHO DMH8YMP MN Plasmodium Plasmepsin 2 (Malaria PLA2) DMH8YMP MT DTT DMH8YMP MA Inhibitor DMH8YMP RN Identification of potent inhibitors of Plasmodium falciparum plasmepsin II from an encoded statine combinatorial library. Bioorg Med Chem Lett. 1998 Sep 8;8(17):2315-20. DMH8YMP RU https://pubmed.ncbi.nlm.nih.gov/9873534 DMT4YFR DI DMT4YFR DMT4YFR DN PS-662477 DMT4YFR MI TTXMNHO DMT4YFR MN Plasmodium Plasmepsin 2 (Malaria PLA2) DMT4YFR MT DTT DMT4YFR MA Inhibitor DMT4YFR RN Identification of potent inhibitors of Plasmodium falciparum plasmepsin II from an encoded statine combinatorial library. Bioorg Med Chem Lett. 1998 Sep 8;8(17):2315-20. DMT4YFR RU https://pubmed.ncbi.nlm.nih.gov/9873534 DM05DOF DI DM05DOF DM05DOF DN PS-725074 DM05DOF MI TTXMNHO DM05DOF MN Plasmodium Plasmepsin 2 (Malaria PLA2) DM05DOF MT DTT DM05DOF MA Inhibitor DM05DOF RN Identification of potent inhibitors of Plasmodium falciparum plasmepsin II from an encoded statine combinatorial library. Bioorg Med Chem Lett. 1998 Sep 8;8(17):2315-20. DM05DOF RU https://pubmed.ncbi.nlm.nih.gov/9873534 DM3F7SD DI DM3F7SD DM3F7SD DN PS-777621 DM3F7SD MI TTH9VL3 DM3F7SD MN Plasmodium Plasmepsin 1 (Malaria PLA1) DM3F7SD MT DTT DM3F7SD MA Inhibitor DM3F7SD RN High antiplasmodial activity of novel plasmepsins I and II inhibitors. J Med Chem. 2006 Dec 14;49(25):7440-9. DM3F7SD RU https://pubmed.ncbi.nlm.nih.gov/17149873 DM3F7SD DI DM3F7SD DM3F7SD DN PS-777621 DM3F7SD MI TTXMNHO DM3F7SD MN Plasmodium Plasmepsin 2 (Malaria PLA2) DM3F7SD MT DTT DM3F7SD MA Inhibitor DM3F7SD RN High antiplasmodial activity of novel plasmepsins I and II inhibitors. J Med Chem. 2006 Dec 14;49(25):7440-9. DM3F7SD RU https://pubmed.ncbi.nlm.nih.gov/17149873 DM38JMK DI DM38JMK DM38JMK DN PSAB-OFP DM38JMK MI TTLA931 DM38JMK MN Neuronal acetylcholine receptor alpha-7 (CHRNA7) DM38JMK MT DTT DM38JMK MA Agonist DM38JMK RN PSAB-OFP, a selective alpha 7 nicotinic receptor agonist, is also a potent agonist of the 5-HT3 receptor. Eur J Pharmacol. 2002 Oct 4;452(2):137-44. DM38JMK RU https://pubmed.ncbi.nlm.nih.gov/12354563 DM6T0IQ DI DM6T0IQ DM6T0IQ DN PSAMMAPLIN A DM6T0IQ MI TTBH0VX DM6T0IQ MN Histone deacetylase (HDAC) DM6T0IQ MT DTT DM6T0IQ MA Inhibitor DM6T0IQ RN Histone deacetylase inhibitors. J Med Chem. 2003 Nov 20;46(24):5097-116. DM6T0IQ RU https://pubmed.ncbi.nlm.nih.gov/14613312 DM6T0IQ DI DM6T0IQ DM6T0IQ DN PSAMMAPLIN A DM6T0IQ MI TT6R7JZ DM6T0IQ MN Histone deacetylase 1 (HDAC1) DM6T0IQ MT DTT DM6T0IQ MA Inhibitor DM6T0IQ RN Histone deacetylase inhibitors. J Med Chem. 2003 Nov 20;46(24):5097-116. DM6T0IQ RU https://pubmed.ncbi.nlm.nih.gov/14613312 DM6T0IQ DI DM6T0IQ DM6T0IQ DN PSAMMAPLIN A DM6T0IQ MI TTYHPU6 DM6T0IQ MN Histone deacetylase 10 (HDAC10) DM6T0IQ MT DTT DM6T0IQ MA Inhibitor DM6T0IQ RN Histone deacetylase inhibitors. J Med Chem. 2003 Nov 20;46(24):5097-116. DM6T0IQ RU https://pubmed.ncbi.nlm.nih.gov/14613312 DM6T0IQ DI DM6T0IQ DM6T0IQ DN PSAMMAPLIN A DM6T0IQ MI TTSHTOI DM6T0IQ MN Histone deacetylase 2 (HDAC2) DM6T0IQ MT DTT DM6T0IQ MA Inhibitor DM6T0IQ RN Histone deacetylase inhibitors. J Med Chem. 2003 Nov 20;46(24):5097-116. DM6T0IQ RU https://pubmed.ncbi.nlm.nih.gov/14613312 DM6T0IQ DI DM6T0IQ DM6T0IQ DN PSAMMAPLIN A DM6T0IQ MI TTTQGH8 DM6T0IQ MN Histone deacetylase 4 (HDAC4) DM6T0IQ MT DTT DM6T0IQ MA Inhibitor DM6T0IQ RN Histone deacetylase inhibitors. J Med Chem. 2003 Nov 20;46(24):5097-116. DM6T0IQ RU https://pubmed.ncbi.nlm.nih.gov/14613312 DM6T0IQ DI DM6T0IQ DM6T0IQ DN PSAMMAPLIN A DM6T0IQ MI TT5ZKDI DM6T0IQ MN Histone deacetylase 6 (HDAC6) DM6T0IQ MT DTT DM6T0IQ MA Inhibitor DM6T0IQ RN Histone deacetylase inhibitors. J Med Chem. 2003 Nov 20;46(24):5097-116. DM6T0IQ RU https://pubmed.ncbi.nlm.nih.gov/14613312 DM6T0IQ DI DM6T0IQ DM6T0IQ DN PSAMMAPLIN A DM6T0IQ MI TTT6LFV DM6T0IQ MN Histone deacetylase 8 (HDAC8) DM6T0IQ MT DTT DM6T0IQ MA Inhibitor DM6T0IQ RN Histone deacetylase inhibitors. J Med Chem. 2003 Nov 20;46(24):5097-116. DM6T0IQ RU https://pubmed.ncbi.nlm.nih.gov/14613312 DM6T0IQ DI DM6T0IQ DM6T0IQ DN PSAMMAPLIN A DM6T0IQ MI TTGRHIB DM6T0IQ MN UDP-glucose 4-epimerase (GALE) DM6T0IQ MT DTT DM6T0IQ MA Inhibitor DM6T0IQ RN Identification of novel inhibitors of UDP-Glc 4'-epimerase, a validated drug target for african sleeping sickness. Bioorg Med Chem Lett. 2006 Nov 15;16(22):5744-7. DM6T0IQ RU https://pubmed.ncbi.nlm.nih.gov/16962325 DMLAFJE DI DMLAFJE DMLAFJE DN PSB-0702 DMLAFJE MI TTZ1DT0 DMLAFJE MN P2Y purinoceptor 12 (P2RY12) DMLAFJE MT DTT DMLAFJE MA Inhibitor DMLAFJE RN High-affinity, non-nucleotide-derived competitive antagonists of platelet P2Y12 receptors. J Med Chem. 2009 Jun 25;52(12):3784-93. DMLAFJE RU https://pubmed.ncbi.nlm.nih.gov/19463000 DM3AZPD DI DM3AZPD DM3AZPD DN PSB-0739 DM3AZPD MI TTZ1DT0 DM3AZPD MN P2Y purinoceptor 12 (P2RY12) DM3AZPD MT DTT DM3AZPD MA Inhibitor DM3AZPD RN High-affinity, non-nucleotide-derived competitive antagonists of platelet P2Y12 receptors. J Med Chem. 2009 Jun 25;52(12):3784-93. DM3AZPD RU https://pubmed.ncbi.nlm.nih.gov/19463000 DM0FKV9 DI DM0FKV9 DM0FKV9 DN PSB-0788 DM0FKV9 MI TTK25J1 DM0FKV9 MN Adenosine A1 receptor (ADORA1) DM0FKV9 MT DTT DM0FKV9 MA Inhibitor DM0FKV9 RN 1-alkyl-8-(piperazine-1-sulfonyl)phenylxanthines: development and characterization of adenosine A2B receptor antagonists and a new radioligand with... J Med Chem. 2009 Jul 9;52(13):3994-4006. DM0FKV9 RU https://pubmed.ncbi.nlm.nih.gov/19569717 DM0FKV9 DI DM0FKV9 DM0FKV9 DN PSB-0788 DM0FKV9 MI TTM2AOE DM0FKV9 MN Adenosine A2a receptor (ADORA2A) DM0FKV9 MT DTT DM0FKV9 MA Inhibitor DM0FKV9 RN 1-alkyl-8-(piperazine-1-sulfonyl)phenylxanthines: development and characterization of adenosine A2B receptor antagonists and a new radioligand with... J Med Chem. 2009 Jul 9;52(13):3994-4006. DM0FKV9 RU https://pubmed.ncbi.nlm.nih.gov/19569717 DM0FKV9 DI DM0FKV9 DM0FKV9 DN PSB-0788 DM0FKV9 MI TTNE7KG DM0FKV9 MN Adenosine A2b receptor (ADORA2B) DM0FKV9 MT DTT DM0FKV9 MA Inhibitor DM0FKV9 RN 1-alkyl-8-(piperazine-1-sulfonyl)phenylxanthines: development and characterization of adenosine A2B receptor antagonists and a new radioligand with... J Med Chem. 2009 Jul 9;52(13):3994-4006. DM0FKV9 RU https://pubmed.ncbi.nlm.nih.gov/19569717 DMAFHLX DI DMAFHLX DMAFHLX DN PSB-09120 DMAFHLX MI TTM2AOE DMAFHLX MN Adenosine A2a receptor (ADORA2A) DMAFHLX MT DTT DMAFHLX MA Inhibitor DMAFHLX RN 1-alkyl-8-(piperazine-1-sulfonyl)phenylxanthines: development and characterization of adenosine A2B receptor antagonists and a new radioligand with... J Med Chem. 2009 Jul 9;52(13):3994-4006. DMAFHLX RU https://pubmed.ncbi.nlm.nih.gov/19569717 DMAFHLX DI DMAFHLX DMAFHLX DN PSB-09120 DMAFHLX MI TTNE7KG DMAFHLX MN Adenosine A2b receptor (ADORA2B) DMAFHLX MT DTT DMAFHLX MA Inhibitor DMAFHLX RN 1-alkyl-8-(piperazine-1-sulfonyl)phenylxanthines: development and characterization of adenosine A2B receptor antagonists and a new radioligand with... J Med Chem. 2009 Jul 9;52(13):3994-4006. DMAFHLX RU https://pubmed.ncbi.nlm.nih.gov/19569717 DMW19LB DI DMW19LB DMW19LB DN PSB-0952 DMW19LB MI TTK0O6Y DMW19LB MN Ecto-5'-nucleotidase (CD73) DMW19LB MT DTT DMW19LB MA Inhibitor DMW19LB RN Development of potent and selective inhibitors of ecto-5'-nucleotidase based on an anthraquinone scaffold. J Med Chem. 2010 Mar 11;53(5):2076-86. DMW19LB RU https://pubmed.ncbi.nlm.nih.gov/20146483 DMW19LB DI DMW19LB DMW19LB DN PSB-0952 DMW19LB MI TTNVSKA DMW19LB MN P2Y purinoceptor 6 (P2RY6) DMW19LB MT DTT DMW19LB MA Inhibitor DMW19LB RN Development of potent and selective inhibitors of ecto-5'-nucleotidase based on an anthraquinone scaffold. J Med Chem. 2010 Mar 11;53(5):2076-86. DMW19LB RU https://pubmed.ncbi.nlm.nih.gov/20146483 DMBDVJ1 DI DMBDVJ1 DMBDVJ1 DN PSB-0963 DMBDVJ1 MI TTK0O6Y DMBDVJ1 MN Ecto-5'-nucleotidase (CD73) DMBDVJ1 MT DTT DMBDVJ1 MA Inhibitor DMBDVJ1 RN Development of potent and selective inhibitors of ecto-5'-nucleotidase based on an anthraquinone scaffold. J Med Chem. 2010 Mar 11;53(5):2076-86. DMBDVJ1 RU https://pubmed.ncbi.nlm.nih.gov/20146483 DMBDVJ1 DI DMBDVJ1 DMBDVJ1 DN PSB-0963 DMBDVJ1 MI TTYM8DJ DMBDVJ1 MN Ectonucleoside triphosphate diphosphohydrolase 1 (CD39) DMBDVJ1 MT DTT DMBDVJ1 MA Inhibitor DMBDVJ1 RN Development of potent and selective inhibitors of ecto-5'-nucleotidase based on an anthraquinone scaffold. J Med Chem. 2010 Mar 11;53(5):2076-86. DMBDVJ1 RU https://pubmed.ncbi.nlm.nih.gov/20146483 DMBDVJ1 DI DMBDVJ1 DMBDVJ1 DN PSB-0963 DMBDVJ1 MI TTOZHQC DMBDVJ1 MN P2Y purinoceptor 2 (P2RY2) DMBDVJ1 MT DTT DMBDVJ1 MA Inhibitor DMBDVJ1 RN Development of potent and selective inhibitors of ecto-5'-nucleotidase based on an anthraquinone scaffold. J Med Chem. 2010 Mar 11;53(5):2076-86. DMBDVJ1 RU https://pubmed.ncbi.nlm.nih.gov/20146483 DMXDWO7 DI DMXDWO7 DMXDWO7 DN PSB-10 DMXDWO7 MI TTK25J1 DMXDWO7 MN Adenosine A1 receptor (ADORA1) DMXDWO7 MT DTT DMXDWO7 MA Antagonist DMXDWO7 RN 2-Phenylimidazo[2,1-i]purin-5-ones: structure-activity relationships and characterization of potent and selective inverse agonists at Human A3 adenosine receptors. Bioorg Med Chem. 2003 Feb 6;11(3):347-56. DMXDWO7 RU https://pubmed.ncbi.nlm.nih.gov/12517430 DMXDWO7 DI DMXDWO7 DMXDWO7 DN PSB-10 DMXDWO7 MI TTNE7KG DMXDWO7 MN Adenosine A2b receptor (ADORA2B) DMXDWO7 MT DTT DMXDWO7 MA Antagonist DMXDWO7 RN Imidazo[2,1-i]purin-5-ones and related tricyclic water-soluble purine derivatives: potent A(2A)- and A(3)-adenosine receptor antagonists. J Med Chem. 2002 Aug 1;45(16):3440-50. DMXDWO7 RU https://pubmed.ncbi.nlm.nih.gov/12139454 DMXDWO7 DI DMXDWO7 DMXDWO7 DN PSB-10 DMXDWO7 MI TTJFY5U DMXDWO7 MN Adenosine A3 receptor (ADORA3) DMXDWO7 MT DTT DMXDWO7 MA Antagonist DMXDWO7 RN Imidazo[2,1-i]purin-5-ones and related tricyclic water-soluble purine derivatives: potent A(2A)- and A(3)-adenosine receptor antagonists. J Med Chem. 2002 Aug 1;45(16):3440-50. DMXDWO7 RU https://pubmed.ncbi.nlm.nih.gov/12139454 DMGK2PC DI DMGK2PC DMGK2PC DN PSB-11 DMGK2PC MI TTK25J1 DMGK2PC MN Adenosine A1 receptor (ADORA1) DMGK2PC MT DTT DMGK2PC MA Antagonist DMGK2PC RN 2-Phenylimidazo[2,1-i]purin-5-ones: structure-activity relationships and characterization of potent and selective inverse agonists at Human A3 adenosine receptors. Bioorg Med Chem. 2003 Feb 6;11(3):347-56. DMGK2PC RU https://pubmed.ncbi.nlm.nih.gov/12517430 DMGK2PC DI DMGK2PC DMGK2PC DN PSB-11 DMGK2PC MI TTNE7KG DMGK2PC MN Adenosine A2b receptor (ADORA2B) DMGK2PC MT DTT DMGK2PC MA Antagonist DMGK2PC RN Imidazo[2,1-i]purin-5-ones and related tricyclic water-soluble purine derivatives: potent A(2A)- and A(3)-adenosine receptor antagonists. J Med Chem. 2002 Aug 1;45(16):3440-50. DMGK2PC RU https://pubmed.ncbi.nlm.nih.gov/12139454 DMGK2PC DI DMGK2PC DMGK2PC DN PSB-11 DMGK2PC MI TTJFY5U DMGK2PC MN Adenosine A3 receptor (ADORA3) DMGK2PC MT DTT DMGK2PC MA Antagonist DMGK2PC RN [(3)H]8-Ethyl-4-methyl-2-phenyl-(8R)-4,5,7,8-tetrahydro-1H-imidazo[2,1-i]-purin-5-one ([(3)H]PSB-11), a novel high-affinity antagonist radioligand for human A(3) adenosine receptors. Bioorg Med Chem Lett. 2002 Feb 11;12(3):501-3. DMGK2PC RU https://pubmed.ncbi.nlm.nih.gov/11814828 DMR9HYI DI DMR9HYI DMR9HYI DN PSB1114 DMR9HYI MI TTOZHQC DMR9HYI MN P2Y purinoceptor 2 (P2RY2) DMR9HYI MT DTT DMR9HYI MA Agonist DMR9HYI RN Structural modifications of UMP, UDP, and UTP leading to subtype-selective agonists for P2Y2, P2Y4, and P2Y6 receptors. J Med Chem. 2011 Apr 28;54(8):2878-90. DMR9HYI RU https://pubmed.ncbi.nlm.nih.gov/21417463 DMOH2VC DI DMOH2VC DMOH2VC DN PSB-1115 DMOH2VC MI TTK25J1 DMOH2VC MN Adenosine A1 receptor (ADORA1) DMOH2VC MT DTT DMOH2VC MA Inhibitor DMOH2VC RN 1-alkyl-8-(piperazine-1-sulfonyl)phenylxanthines: development and characterization of adenosine A2B receptor antagonists and a new radioligand with... J Med Chem. 2009 Jul 9;52(13):3994-4006. DMOH2VC RU https://pubmed.ncbi.nlm.nih.gov/19569717 DMOH2VC DI DMOH2VC DMOH2VC DN PSB-1115 DMOH2VC MI TTNE7KG DMOH2VC MN Adenosine A2b receptor (ADORA2B) DMOH2VC MT DTT DMOH2VC MA Inhibitor DMOH2VC RN 1-alkyl-8-(piperazine-1-sulfonyl)phenylxanthines: development and characterization of adenosine A2B receptor antagonists and a new radioligand with... J Med Chem. 2009 Jul 9;52(13):3994-4006. DMOH2VC RU https://pubmed.ncbi.nlm.nih.gov/19569717 DMBGM1E DI DMBGM1E DMBGM1E DN PSB36 DMBGM1E MI TTK25J1 DMBGM1E MN Adenosine A1 receptor (ADORA1) DMBGM1E MT DTT DMBGM1E MA Antagonist DMBGM1E RN Antinociceptive effects of novel A2B adenosine receptor antagonists. J Pharmacol Exp Ther. 2004 Jan;308(1):358-66. DMBGM1E RU https://pubmed.ncbi.nlm.nih.gov/14563788 DMBGM1E DI DMBGM1E DMBGM1E DN PSB36 DMBGM1E MI TTNE7KG DMBGM1E MN Adenosine A2b receptor (ADORA2B) DMBGM1E MT DTT DMBGM1E MA Antagonist DMBGM1E RN Norbornyllactone-substituted xanthines as adenosine A(1) receptor antagonists. Bioorg Med Chem. 2006 Jun 1;14(11):3654-61. DMBGM1E RU https://pubmed.ncbi.nlm.nih.gov/16458010 DMBGM1E DI DMBGM1E DMBGM1E DN PSB36 DMBGM1E MI TTJFY5U DMBGM1E MN Adenosine A3 receptor (ADORA3) DMBGM1E MT DTT DMBGM1E MA Antagonist DMBGM1E RN Improving potency, selectivity, and water solubility of adenosine A1 receptor antagonists: xanthines modified at position 3 and related pyrimido[1,2,3-cd]purinediones. ChemMedChem. 2006 Aug;1(8):891-902. DMBGM1E RU https://pubmed.ncbi.nlm.nih.gov/16902942 DMBIK7D DI DMBIK7D DMBIK7D DN PSB-601 DMBIK7D MI TTK25J1 DMBIK7D MN Adenosine A1 receptor (ADORA1) DMBIK7D MT DTT DMBIK7D MA Inhibitor DMBIK7D RN 1-alkyl-8-(piperazine-1-sulfonyl)phenylxanthines: development and characterization of adenosine A2B receptor antagonists and a new radioligand with... J Med Chem. 2009 Jul 9;52(13):3994-4006. DMBIK7D RU https://pubmed.ncbi.nlm.nih.gov/19569717 DMBIK7D DI DMBIK7D DMBIK7D DN PSB-601 DMBIK7D MI TTM2AOE DMBIK7D MN Adenosine A2a receptor (ADORA2A) DMBIK7D MT DTT DMBIK7D MA Inhibitor DMBIK7D RN 1-alkyl-8-(piperazine-1-sulfonyl)phenylxanthines: development and characterization of adenosine A2B receptor antagonists and a new radioligand with... J Med Chem. 2009 Jul 9;52(13):3994-4006. DMBIK7D RU https://pubmed.ncbi.nlm.nih.gov/19569717 DMBIK7D DI DMBIK7D DMBIK7D DN PSB-601 DMBIK7D MI TTNE7KG DMBIK7D MN Adenosine A2b receptor (ADORA2B) DMBIK7D MT DTT DMBIK7D MA Inhibitor DMBIK7D RN Insights into binding modes of adenosine A(2B) antagonists with ligand-based and receptor-based methods. Eur J Med Chem. 2010 Aug;45(8):3459-71. DMBIK7D RU https://pubmed.ncbi.nlm.nih.gov/20537438 DM6QERS DI DM6QERS DM6QERS DN PSB603 DM6QERS MI TTK25J1 DM6QERS MN Adenosine A1 receptor (ADORA1) DM6QERS MT DTT DM6QERS MA Antagonist DM6QERS RN 1-alkyl-8-(piperazine-1-sulfonyl)phenylxanthines: development and characterization of adenosine A2B receptor antagonists and a new radioligand with... J Med Chem. 2009 Jul 9;52(13):3994-4006. DM6QERS RU https://pubmed.ncbi.nlm.nih.gov/19569717 DM6QERS DI DM6QERS DM6QERS DN PSB603 DM6QERS MI TTNE7KG DM6QERS MN Adenosine A2b receptor (ADORA2B) DM6QERS MT DTT DM6QERS MA Antagonist DM6QERS RN 1-alkyl-8-(piperazine-1-sulfonyl)phenylxanthines: development and characterization of adenosine A2B receptor antagonists and a new radioligand with... J Med Chem. 2009 Jul 9;52(13):3994-4006. DM6QERS RU https://pubmed.ncbi.nlm.nih.gov/19569717 DM6QERS DI DM6QERS DM6QERS DN PSB603 DM6QERS MI TTJFY5U DM6QERS MN Adenosine A3 receptor (ADORA3) DM6QERS MT DTT DM6QERS MA Antagonist DM6QERS RN 1-alkyl-8-(piperazine-1-sulfonyl)phenylxanthines: development and characterization of adenosine A2B receptor antagonists and a new radioligand with... J Med Chem. 2009 Jul 9;52(13):3994-4006. DM6QERS RU https://pubmed.ncbi.nlm.nih.gov/19569717 DMJ9ML8 DI DMJ9ML8 DMJ9ML8 DN PSB-6426 DMJ9ML8 MI TTYM8DJ DMJ9ML8 MN Ectonucleoside triphosphate diphosphohydrolase 1 (CD39) DMJ9ML8 MT DTT DMJ9ML8 MA Inhibitor DMJ9ML8 RN Selective nucleoside triphosphate diphosphohydrolase-2 (NTPDase2) inhibitors: nucleotide mimetics derived from uridine-5'-carboxamide. J Med Chem. 2008 Aug 14;51(15):4518-28. DMJ9ML8 RU https://pubmed.ncbi.nlm.nih.gov/18630897 DMS2V0P DI DMS2V0P DMS2V0P DN PSB-716 DMS2V0P MI TTOZHQC DMS2V0P MN P2Y purinoceptor 2 (P2RY2) DMS2V0P MT DTT DMS2V0P MA Inhibitor DMS2V0P RN Combinatorial synthesis of anilinoanthraquinone derivatives and evaluation as non-nucleotide-derived P2Y2 receptor antagonists. Bioorg Med Chem Lett. 2008 Jan 1;18(1):223-7. DMS2V0P RU https://pubmed.ncbi.nlm.nih.gov/18006312 DMN5AE8 DI DMN5AE8 DMN5AE8 DN PSEUDOCOCAINE DMN5AE8 MI TTVBI8W DMN5AE8 MN Dopamine transporter (DAT) DMN5AE8 MT DTT DMN5AE8 MA Inhibitor DMN5AE8 RN Synthesis of 8-Oxa analogues of norcocaine endowed with interesting cocaine-like activity. Bioorg Med Chem Lett. 1999 Jul 5;9(13):1831-6. DMN5AE8 RU https://pubmed.ncbi.nlm.nih.gov/10406650 DM0E5G9 DI DM0E5G9 DM0E5G9 DN Pseudocolumbamine trifluoroacetate DM0E5G9 MI TT1RS9F DM0E5G9 MN Acetylcholinesterase (AChE) DM0E5G9 MT DTT DM0E5G9 MA Inhibitor DM0E5G9 RN Characterization of Acetylcholinesterase Inhibitory Constituents from Annona glabra Assisted by HPLC Microfractionation. J Nat Prod. 2010 Oct 22;73(10):1632-5. DM0E5G9 RU https://pubmed.ncbi.nlm.nih.gov/20828184 DM4HE1V DI DM4HE1V DM4HE1V DN Pseudopalmatine trifluoroacetate DM4HE1V MI TT1RS9F DM4HE1V MN Acetylcholinesterase (AChE) DM4HE1V MT DTT DM4HE1V MA Inhibitor DM4HE1V RN Characterization of Acetylcholinesterase Inhibitory Constituents from Annona glabra Assisted by HPLC Microfractionation. J Nat Prod. 2010 Oct 22;73(10):1632-5. DM4HE1V RU https://pubmed.ncbi.nlm.nih.gov/20828184 DM5ZU1V DI DM5ZU1V DM5ZU1V DN PSI 7851 DM5ZU1V MI TTMVBWH DM5ZU1V MN Hepatitis C virus RNA-directed RNA polymerase (HCV NS5B) DM5ZU1V MT DTT DM5ZU1V MA Modulator DM5ZU1V RN Mechanism of activation of PSI-7851 and its diastereoisomer PSI-7977.J Biol Chem.2010 Nov 5;285(45):34337-47. DM5ZU1V RU https://www.ncbi.nlm.nih.gov/pubmed/20801890 DMPDO49 DI DMPDO49 DMPDO49 DN PSILOCIN DMPDO49 MI TTJQOD7 DMPDO49 MN 5-HT 2A receptor (HTR2A) DMPDO49 MT DTT DMPDO49 MA Inhibitor DMPDO49 RN The role of lipophilicity in determining binding affinity and functional activity for 5-HT2A receptor ligands. Bioorg Med Chem. 2008 Apr 15;16(8):4661-9. DMPDO49 RU https://pubmed.ncbi.nlm.nih.gov/18296055 DMUROIY DI DMUROIY DMUROIY DN PSN-101 DMUROIY MI TTDLNGZ DMUROIY MN Glucokinase (GCK) DMUROIY MT DTT DMUROIY MA Activator DMUROIY RN CenterWatch. Drugs in Clinical Trials Database. CenterWatch. 2008. DMUROIY RU http://www.centerwatch.com/ DM2U9SR DI DM2U9SR DM2U9SR DN PSN375963 DM2U9SR MI TT7QNVC DM2U9SR MN Glucose-dependent insulinotropic receptor (GPR119) DM2U9SR MT DTT DM2U9SR MA Agonist DM2U9SR RN Deorphanization of a G protein-coupled receptor for oleoylethanolamide and its use in the discovery of small-molecule hypophagic agents. Cell Metab. 2006 Mar;3(3):167-75. DM2U9SR RU https://pubmed.ncbi.nlm.nih.gov/16517404 DMJIB8N DI DMJIB8N DMJIB8N DN PSN632408 DMJIB8N MI TT7QNVC DMJIB8N MN Glucose-dependent insulinotropic receptor (GPR119) DMJIB8N MT DTT DMJIB8N MA Agonist DMJIB8N RN Deorphanization of a G protein-coupled receptor for oleoylethanolamide and its use in the discovery of small-molecule hypophagic agents. Cell Metab. 2006 Mar;3(3):167-75. DMJIB8N RU https://pubmed.ncbi.nlm.nih.gov/16517404 DMVJDCM DI DMVJDCM DMVJDCM DN PSX-4206 DMVJDCM MI TT7HC21 DMVJDCM MN Membrane copper amine oxidase (AOC3) DMVJDCM MT DTT DMVJDCM MA Inhibitor DMVJDCM RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2767). DMVJDCM RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2767 DM47F9I DI DM47F9I DM47F9I DN PT-101 DM47F9I MI TT84ETX DM47F9I MN Human immunodeficiency virus Reverse transcriptase (HIV RT) DM47F9I MT DTT DM47F9I MA Inhibitor DM47F9I RN Phenethylthiazolethiourea (PETT) compounds, a new class of HIV-1 reverse transcriptase inhibitors. 1. Synthesis and basic structure-activity relati... J Med Chem. 1995 Dec 8;38(25):4929-36. DM47F9I RU https://pubmed.ncbi.nlm.nih.gov/8523406 DMD0K61 DI DMD0K61 DMD0K61 DN PT-102 DMD0K61 MI TT84ETX DMD0K61 MN Human immunodeficiency virus Reverse transcriptase (HIV RT) DMD0K61 MT DTT DMD0K61 MA Inhibitor DMD0K61 RN Antioxidant function of phenethyl-5-bromo-pyridyl thiourea compounds with potent anti-HIV activity. Bioorg Med Chem Lett. 2000 Jan 3;10(1):87-90. DMD0K61 RU https://pubmed.ncbi.nlm.nih.gov/10636251 DM0LTB2 DI DM0LTB2 DM0LTB2 DN PT-103 DM0LTB2 MI TT84ETX DM0LTB2 MN Human immunodeficiency virus Reverse transcriptase (HIV RT) DM0LTB2 MT DTT DM0LTB2 MA Inhibitor DM0LTB2 RN Phenethylthiazolethiourea (PETT) compounds, a new class of HIV-1 reverse transcriptase inhibitors. 1. Synthesis and basic structure-activity relati... J Med Chem. 1995 Dec 8;38(25):4929-36. DM0LTB2 RU https://pubmed.ncbi.nlm.nih.gov/8523406 DMABLF7 DI DMABLF7 DMABLF7 DN PT-104 DMABLF7 MI TT84ETX DMABLF7 MN Human immunodeficiency virus Reverse transcriptase (HIV RT) DMABLF7 MT DTT DMABLF7 MA Inhibitor DMABLF7 RN Phenethylthiazolylthiourea (PETT) compounds as a new class of HIV-1 reverse transcriptase inhibitors. 2. Synthesis and further structure-activity r... J Med Chem. 1996 Oct 11;39(21):4261-74. DMABLF7 RU https://pubmed.ncbi.nlm.nih.gov/8863804 DMPX71O DI DMPX71O DMPX71O DN PT-106 DMPX71O MI TT84ETX DMPX71O MN Human immunodeficiency virus Reverse transcriptase (HIV RT) DMPX71O MT DTT DMPX71O MA Inhibitor DMPX71O RN Phenethylthiazolethiourea (PETT) compounds, a new class of HIV-1 reverse transcriptase inhibitors. 1. Synthesis and basic structure-activity relati... J Med Chem. 1995 Dec 8;38(25):4929-36. DMPX71O RU https://pubmed.ncbi.nlm.nih.gov/8523406 DMBLAV4 DI DMBLAV4 DMBLAV4 DN PT-108 DMBLAV4 MI TT84ETX DMBLAV4 MN Human immunodeficiency virus Reverse transcriptase (HIV RT) DMBLAV4 MT DTT DMBLAV4 MA Inhibitor DMBLAV4 RN Phenethylthiazolethiourea (PETT) compounds, a new class of HIV-1 reverse transcriptase inhibitors. 1. Synthesis and basic structure-activity relati... J Med Chem. 1995 Dec 8;38(25):4929-36. DMBLAV4 RU https://pubmed.ncbi.nlm.nih.gov/8523406 DM8PX1T DI DM8PX1T DM8PX1T DN PT-109 DM8PX1T MI TT84ETX DM8PX1T MN Human immunodeficiency virus Reverse transcriptase (HIV RT) DM8PX1T MT DTT DM8PX1T MA Inhibitor DM8PX1T RN Phenethylthiazolylthiourea (PETT) compounds as a new class of HIV-1 reverse transcriptase inhibitors. 2. Synthesis and further structure-activity r... J Med Chem. 1996 Oct 11;39(21):4261-74. DM8PX1T RU https://pubmed.ncbi.nlm.nih.gov/8863804 DMEIW5T DI DMEIW5T DMEIW5T DN PT-110 DMEIW5T MI TT84ETX DMEIW5T MN Human immunodeficiency virus Reverse transcriptase (HIV RT) DMEIW5T MT DTT DMEIW5T MA Inhibitor DMEIW5T RN Phenethylthiazolylthiourea (PETT) compounds as a new class of HIV-1 reverse transcriptase inhibitors. 2. Synthesis and further structure-activity r... J Med Chem. 1996 Oct 11;39(21):4261-74. DMEIW5T RU https://pubmed.ncbi.nlm.nih.gov/8863804 DMUFC6V DI DMUFC6V DMUFC6V DN PT-113 DMUFC6V MI TT84ETX DMUFC6V MN Human immunodeficiency virus Reverse transcriptase (HIV RT) DMUFC6V MT DTT DMUFC6V MA Inhibitor DMUFC6V RN Phenethylthiazolylthiourea (PETT) compounds as a new class of HIV-1 reverse transcriptase inhibitors. 2. Synthesis and further structure-activity r... J Med Chem. 1996 Oct 11;39(21):4261-74. DMUFC6V RU https://pubmed.ncbi.nlm.nih.gov/8863804 DMYE1P8 DI DMYE1P8 DMYE1P8 DN PT-114 DMYE1P8 MI TT84ETX DMYE1P8 MN Human immunodeficiency virus Reverse transcriptase (HIV RT) DMYE1P8 MT DTT DMYE1P8 MA Inhibitor DMYE1P8 RN Phenethylthiazolylthiourea (PETT) compounds as a new class of HIV-1 reverse transcriptase inhibitors. 2. Synthesis and further structure-activity r... J Med Chem. 1996 Oct 11;39(21):4261-74. DMYE1P8 RU https://pubmed.ncbi.nlm.nih.gov/8863804 DMS01IN DI DMS01IN DMS01IN DN PT-115 DMS01IN MI TT84ETX DMS01IN MN Human immunodeficiency virus Reverse transcriptase (HIV RT) DMS01IN MT DTT DMS01IN MA Inhibitor DMS01IN RN Phenethylthiazolylthiourea (PETT) compounds as a new class of HIV-1 reverse transcriptase inhibitors. 2. Synthesis and further structure-activity r... J Med Chem. 1996 Oct 11;39(21):4261-74. DMS01IN RU https://pubmed.ncbi.nlm.nih.gov/8863804 DME0N2Z DI DME0N2Z DME0N2Z DN PT-306 DME0N2Z MI TT84ETX DME0N2Z MN Human immunodeficiency virus Reverse transcriptase (HIV RT) DME0N2Z MT DTT DME0N2Z MA Inhibitor DME0N2Z RN Phenethylthiazolethiourea (PETT) compounds, a new class of HIV-1 reverse transcriptase inhibitors. 1. Synthesis and basic structure-activity relati... J Med Chem. 1995 Dec 8;38(25):4929-36. DME0N2Z RU https://pubmed.ncbi.nlm.nih.gov/8523406 DM45HVR DI DM45HVR DM45HVR DN PT-307 DM45HVR MI TT84ETX DM45HVR MN Human immunodeficiency virus Reverse transcriptase (HIV RT) DM45HVR MT DTT DM45HVR MA Inhibitor DM45HVR RN Phenethylthiazolethiourea (PETT) compounds, a new class of HIV-1 reverse transcriptase inhibitors. 1. Synthesis and basic structure-activity relati... J Med Chem. 1995 Dec 8;38(25):4929-36. DM45HVR RU https://pubmed.ncbi.nlm.nih.gov/8523406 DM7FM8V DI DM7FM8V DM7FM8V DN PT-308 DM7FM8V MI TT84ETX DM7FM8V MN Human immunodeficiency virus Reverse transcriptase (HIV RT) DM7FM8V MT DTT DM7FM8V MA Inhibitor DM7FM8V RN Phenethylthiazolethiourea (PETT) compounds, a new class of HIV-1 reverse transcriptase inhibitors. 1. Synthesis and basic structure-activity relati... J Med Chem. 1995 Dec 8;38(25):4929-36. DM7FM8V RU https://pubmed.ncbi.nlm.nih.gov/8523406 DM7TILD DI DM7TILD DM7TILD DN PT-309 DM7TILD MI TT84ETX DM7TILD MN Human immunodeficiency virus Reverse transcriptase (HIV RT) DM7TILD MT DTT DM7TILD MA Inhibitor DM7TILD RN Phenethylthiazolethiourea (PETT) compounds, a new class of HIV-1 reverse transcriptase inhibitors. 1. Synthesis and basic structure-activity relati... J Med Chem. 1995 Dec 8;38(25):4929-36. DM7TILD RU https://pubmed.ncbi.nlm.nih.gov/8523406 DMT7G32 DI DMT7G32 DMT7G32 DN PT-310 DMT7G32 MI TT84ETX DMT7G32 MN Human immunodeficiency virus Reverse transcriptase (HIV RT) DMT7G32 MT DTT DMT7G32 MA Inhibitor DMT7G32 RN Phenethylthiazolethiourea (PETT) compounds, a new class of HIV-1 reverse transcriptase inhibitors. 1. Synthesis and basic structure-activity relati... J Med Chem. 1995 Dec 8;38(25):4929-36. DMT7G32 RU https://pubmed.ncbi.nlm.nih.gov/8523406 DM9ZCGX DI DM9ZCGX DM9ZCGX DN PT-311 DM9ZCGX MI TT84ETX DM9ZCGX MN Human immunodeficiency virus Reverse transcriptase (HIV RT) DM9ZCGX MT DTT DM9ZCGX MA Inhibitor DM9ZCGX RN Phenethylthiazolethiourea (PETT) compounds, a new class of HIV-1 reverse transcriptase inhibitors. 1. Synthesis and basic structure-activity relati... J Med Chem. 1995 Dec 8;38(25):4929-36. DM9ZCGX RU https://pubmed.ncbi.nlm.nih.gov/8523406 DM7GN3E DI DM7GN3E DM7GN3E DN PT-312 DM7GN3E MI TT84ETX DM7GN3E MN Human immunodeficiency virus Reverse transcriptase (HIV RT) DM7GN3E MT DTT DM7GN3E MA Inhibitor DM7GN3E RN Phenethylthiazolethiourea (PETT) compounds, a new class of HIV-1 reverse transcriptase inhibitors. 1. Synthesis and basic structure-activity relati... J Med Chem. 1995 Dec 8;38(25):4929-36. DM7GN3E RU https://pubmed.ncbi.nlm.nih.gov/8523406 DMN80XD DI DMN80XD DMN80XD DN PT-313 DMN80XD MI TT84ETX DMN80XD MN Human immunodeficiency virus Reverse transcriptase (HIV RT) DMN80XD MT DTT DMN80XD MA Inhibitor DMN80XD RN Phenethylthiazolethiourea (PETT) compounds, a new class of HIV-1 reverse transcriptase inhibitors. 1. Synthesis and basic structure-activity relati... J Med Chem. 1995 Dec 8;38(25):4929-36. DMN80XD RU https://pubmed.ncbi.nlm.nih.gov/8523406 DM5C1ND DI DM5C1ND DM5C1ND DN PT-314 DM5C1ND MI TT84ETX DM5C1ND MN Human immunodeficiency virus Reverse transcriptase (HIV RT) DM5C1ND MT DTT DM5C1ND MA Inhibitor DM5C1ND RN Phenethylthiazolethiourea (PETT) compounds, a new class of HIV-1 reverse transcriptase inhibitors. 1. Synthesis and basic structure-activity relati... J Med Chem. 1995 Dec 8;38(25):4929-36. DM5C1ND RU https://pubmed.ncbi.nlm.nih.gov/8523406 DMUK7IT DI DMUK7IT DMUK7IT DN PT-315 DMUK7IT MI TT84ETX DMUK7IT MN Human immunodeficiency virus Reverse transcriptase (HIV RT) DMUK7IT MT DTT DMUK7IT MA Inhibitor DMUK7IT RN Phenethylthiazolethiourea (PETT) compounds, a new class of HIV-1 reverse transcriptase inhibitors. 1. Synthesis and basic structure-activity relati... J Med Chem. 1995 Dec 8;38(25):4929-36. DMUK7IT RU https://pubmed.ncbi.nlm.nih.gov/8523406 DMXM6NT DI DMXM6NT DMXM6NT DN PT-316 DMXM6NT MI TT84ETX DMXM6NT MN Human immunodeficiency virus Reverse transcriptase (HIV RT) DMXM6NT MT DTT DMXM6NT MA Inhibitor DMXM6NT RN Phenethylthiazolethiourea (PETT) compounds, a new class of HIV-1 reverse transcriptase inhibitors. 1. Synthesis and basic structure-activity relati... J Med Chem. 1995 Dec 8;38(25):4929-36. DMXM6NT RU https://pubmed.ncbi.nlm.nih.gov/8523406 DM14XB7 DI DM14XB7 DM14XB7 DN PT-317 DM14XB7 MI TT84ETX DM14XB7 MN Human immunodeficiency virus Reverse transcriptase (HIV RT) DM14XB7 MT DTT DM14XB7 MA Inhibitor DM14XB7 RN Phenethylthiazolethiourea (PETT) compounds, a new class of HIV-1 reverse transcriptase inhibitors. 1. Synthesis and basic structure-activity relati... J Med Chem. 1995 Dec 8;38(25):4929-36. DM14XB7 RU https://pubmed.ncbi.nlm.nih.gov/8523406 DMKEPGN DI DMKEPGN DMKEPGN DN PT-319 DMKEPGN MI TT84ETX DMKEPGN MN Human immunodeficiency virus Reverse transcriptase (HIV RT) DMKEPGN MT DTT DMKEPGN MA Inhibitor DMKEPGN RN Phenethylthiazolethiourea (PETT) compounds, a new class of HIV-1 reverse transcriptase inhibitors. 1. Synthesis and basic structure-activity relati... J Med Chem. 1995 Dec 8;38(25):4929-36. DMKEPGN RU https://pubmed.ncbi.nlm.nih.gov/8523406 DMV940C DI DMV940C DMV940C DN PT-320 DMV940C MI TT84ETX DMV940C MN Human immunodeficiency virus Reverse transcriptase (HIV RT) DMV940C MT DTT DMV940C MA Inhibitor DMV940C RN Phenethylthiazolethiourea (PETT) compounds, a new class of HIV-1 reverse transcriptase inhibitors. 1. Synthesis and basic structure-activity relati... J Med Chem. 1995 Dec 8;38(25):4929-36. DMV940C RU https://pubmed.ncbi.nlm.nih.gov/8523406 DMIHSEV DI DMIHSEV DMIHSEV DN PT-322 DMIHSEV MI TT84ETX DMIHSEV MN Human immunodeficiency virus Reverse transcriptase (HIV RT) DMIHSEV MT DTT DMIHSEV MA Inhibitor DMIHSEV RN Phenethylthiazolethiourea (PETT) compounds, a new class of HIV-1 reverse transcriptase inhibitors. 1. Synthesis and basic structure-activity relati... J Med Chem. 1995 Dec 8;38(25):4929-36. DMIHSEV RU https://pubmed.ncbi.nlm.nih.gov/8523406 DM736T8 DI DM736T8 DM736T8 DN PT-401 DM736T8 MI TTAUX24 DM736T8 MN Erythropoietin Receptor (EPOR) DM736T8 MT DTT DM736T8 MA Stimulator DM736T8 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1718). DM736T8 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1718 DMEJ6SK DI DMEJ6SK DMEJ6SK DN PTAC DMEJ6SK MI TTYEG6Q DMEJ6SK MN Muscarinic acetylcholine receptor M2 (CHRM2) DMEJ6SK MT DTT DMEJ6SK MA Agonist DMEJ6SK RN Function of pulmonary neuronal M(2) muscarinic receptors in stable chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2001 May;163(6):1320-5. DMEJ6SK RU https://pubmed.ncbi.nlm.nih.gov/11371395 DMEJ6SK DI DMEJ6SK DMEJ6SK DN PTAC DMEJ6SK MI TTQ13Z5 DMEJ6SK MN Muscarinic acetylcholine receptor M3 (CHRM3) DMEJ6SK MT DTT DMEJ6SK MA Antagonist DMEJ6SK RN Which muscarinic receptor is important in the bladder World J Urol. 2001 Nov;19(5):299-306. DMEJ6SK RU https://pubmed.ncbi.nlm.nih.gov/11760777 DMEJ6SK DI DMEJ6SK DMEJ6SK DN PTAC DMEJ6SK MI TTQ3JTF DMEJ6SK MN Muscarinic acetylcholine receptor M4 (CHRM4) DMEJ6SK MT DTT DMEJ6SK MA Agonist DMEJ6SK RN Function of pulmonary neuronal M(2) muscarinic receptors in stable chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2001 May;163(6):1320-5. DMEJ6SK RU https://pubmed.ncbi.nlm.nih.gov/11371395 DMY02IR DI DMY02IR DMY02IR DN PTBE DMY02IR MI TTXJ47W DMY02IR MN Metabotropic glutamate receptor 2 (mGluR2) DMY02IR MT DTT DMY02IR MA Modulator (allosteric modulator) DMY02IR RN Phenyl-tetrazolyl acetophenones: discovery of positive allosteric potentiatiors for the metabotropic glutamate 2 receptor. J Med Chem. 2004 Aug 26;47(18):4595-9. DMY02IR RU https://pubmed.ncbi.nlm.nih.gov/15317469 DM1NM5F DI DM1NM5F DM1NM5F DN PTeB DM1NM5F MI TTHS256 DM1NM5F MN Metabotropic glutamate receptor 5 (mGluR5) DM1NM5F MT DTT DM1NM5F MA Modulator (allosteric modulator) DM1NM5F RN Discovery of novel heteroarylazoles that are metabotropic glutamate subtype 5 receptor antagonists with anxiolytic activity. J Med Chem. 2004 Sep 9;47(19):4645-8. Letter DM1NM5F RU https://pubmed.ncbi.nlm.nih.gov/15341479 DM98IOX DI DM98IOX DM98IOX DN Pterin-6-Yl-Methyl-Monophosphate DM98IOX MI TT4ILYC DM98IOX MN Bacterial Dihydropteroate synthetase (Bact folP) DM98IOX MT DTT DM98IOX MA Inhibitor DM98IOX RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DM98IOX RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMT2YNG DI DMT2YNG DMT2YNG DN Pteroic Acid DMT2YNG MI TT4ILYC DMT2YNG MN Bacterial Dihydropteroate synthetase (Bact folP) DMT2YNG MT DTT DMT2YNG MA Inhibitor DMT2YNG RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DMT2YNG RU https://pubmed.ncbi.nlm.nih.gov/10592235 DM10KIW DI DM10KIW DM10KIW DN PTHr pepducins DM10KIW MI TTEPJL5 DM10KIW MN Parathyroid hormone receptor (PTH2R) DM10KIW MT DTT DM10KIW MA Modulator DM10KIW RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 332). DM10KIW RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=332 DMQUSXK DI DMQUSXK DMQUSXK DN PTI-601 DMQUSXK MI TTAWNKZ DMQUSXK MN Norepinephrine transporter (NET) DMQUSXK MT DTT DMQUSXK MA Inhibitor DMQUSXK RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 926). DMQUSXK RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=926 DMQUSXK DI DMQUSXK DMQUSXK DN PTI-601 DMQUSXK MI TTKWM86 DMQUSXK MN Opioid receptor mu (MOP) DMQUSXK MT DTT DMQUSXK MA Modulator DMQUSXK RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 319). DMQUSXK RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=319 DMAEL4C DI DMAEL4C DMAEL4C DN PTL-101 DMAEL4C MI TTP4520 DMAEL4C MN TGF-beta receptor type I (TGFBR1) DMAEL4C MT DTT DMAEL4C MA Modulator DMAEL4C RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1788). DMAEL4C RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1788 DMPEKTO DI DMPEKTO DMPEKTO DN P-toluenesulfonamide DMPEKTO MI TTUNARX DMPEKTO MN Carbonic anhydrase (CA) DMPEKTO MT DTT DMPEKTO MA Inhibitor DMPEKTO RN Cloning, expression, post-translational modifications and inhibition studies on the latest mammalian carbonic anhydrase isoform, CA XV. J Med Chem. 2009 Feb 12;52(3):646-54. DMPEKTO RU https://pubmed.ncbi.nlm.nih.gov/19193158 DMPEKTO DI DMPEKTO DMPEKTO DN P-toluenesulfonamide DMPEKTO MI TTANPDJ DMPEKTO MN Carbonic anhydrase II (CA-II) DMPEKTO MT DTT DMPEKTO MA Inhibitor DMPEKTO RN Carbonic anhydrase inhibitors. Characterization and inhibition studies of the most active beta-carbonic anhydrase from Mycobacterium tuberculosis, ... Bioorg Med Chem Lett. 2009 Dec 1;19(23):6649-54. DMPEKTO RU https://pubmed.ncbi.nlm.nih.gov/19846301 DMPEKTO DI DMPEKTO DMPEKTO DN P-toluenesulfonamide DMPEKTO MI TT2LVK8 DMPEKTO MN Carbonic anhydrase IX (CA-IX) DMPEKTO MT DTT DMPEKTO MA Inhibitor DMPEKTO RN Cloning, expression, post-translational modifications and inhibition studies on the latest mammalian carbonic anhydrase isoform, CA XV. J Med Chem. 2009 Feb 12;52(3):646-54. DMPEKTO RU https://pubmed.ncbi.nlm.nih.gov/19193158 DMPEKTO DI DMPEKTO DMPEKTO DN P-toluenesulfonamide DMPEKTO MI TTCFSPE DMPEKTO MN Carbonic anhydrase VI (CA-VI) DMPEKTO MT DTT DMPEKTO MA Inhibitor DMPEKTO RN Cloning, expression, post-translational modifications and inhibition studies on the latest mammalian carbonic anhydrase isoform, CA XV. J Med Chem. 2009 Feb 12;52(3):646-54. DMPEKTO RU https://pubmed.ncbi.nlm.nih.gov/19193158 DMPEKTO DI DMPEKTO DMPEKTO DN P-toluenesulfonamide DMPEKTO MI TTSYM0R DMPEKTO MN Carbonic anhydrase XII (CA-XII) DMPEKTO MT DTT DMPEKTO MA Inhibitor DMPEKTO RN Carbonic anhydrase inhibitors. Inhibition of the transmembrane isozyme XII with sulfonamides-a new target for the design of antitumor and antiglauc... Bioorg Med Chem Lett. 2005 Feb 15;15(4):963-9. DMPEKTO RU https://pubmed.ncbi.nlm.nih.gov/15686894 DMDGUEK DI DMDGUEK DMDGUEK DN P-tolyl 10H-phenothiazine-10-carboxylate DMDGUEK MI TTEB0GD DMDGUEK MN Cholinesterase (BCHE) DMDGUEK MT DTT DMDGUEK MA Inhibitor DMDGUEK RN Carbamates with differential mechanism of inhibition toward acetylcholinesterase and butyrylcholinesterase. J Med Chem. 2008 Jul 24;51(14):4200-12. DMDGUEK RU https://pubmed.ncbi.nlm.nih.gov/18570368 DM8MZF4 DI DM8MZF4 DM8MZF4 DN P-tolylboronic acid DM8MZF4 MI TTUNARX DM8MZF4 MN Carbonic anhydrase (CA) DM8MZF4 MT DTT DM8MZF4 MA Inhibitor DM8MZF4 RN Carbonic anhydrase inhibitors. Inhibition of the fungal beta-carbonic anhydrases from Candida albicans and Cryptococcus neoformans with boronic acids. Bioorg Med Chem Lett. 2009 May 15;19(10):2642-5. DM8MZF4 RU https://pubmed.ncbi.nlm.nih.gov/19375309 DM8MZF4 DI DM8MZF4 DM8MZF4 DN P-tolylboronic acid DM8MZF4 MI TTANPDJ DM8MZF4 MN Carbonic anhydrase II (CA-II) DM8MZF4 MT DTT DM8MZF4 MA Inhibitor DM8MZF4 RN Carbonic anhydrase inhibitors. Inhibition of the fungal beta-carbonic anhydrases from Candida albicans and Cryptococcus neoformans with boronic acids. Bioorg Med Chem Lett. 2009 May 15;19(10):2642-5. DM8MZF4 RU https://pubmed.ncbi.nlm.nih.gov/19375309 DMPEVQT DI DMPEVQT DMPEVQT DN PTosyl-Glu(OtBu)-Ala-LeuVSMe DMPEVQT MI TTF2LRI DMPEVQT MN Cathepsin B (CTSB) DMPEVQT MT DTT DMPEVQT MA Inhibitor DMPEVQT RN Optimization of subsite binding to the beta5 subunit of the human 20S proteasome using vinyl sulfones and 2-keto-1,3,4-oxadiazoles: syntheses and c... J Med Chem. 2006 May 18;49(10):2953-68. DMPEVQT RU https://pubmed.ncbi.nlm.nih.gov/16686537 DMZGFE8 DI DMZGFE8 DMZGFE8 DN PTR-3046 DMZGFE8 MI TT2BC4G DMZGFE8 MN Somatostatin receptor type 5 (SSTR5) DMZGFE8 MT DTT DMZGFE8 MA Inhibitor DMZGFE8 RN Highly potent 4-amino-indolo[2,3-c]azepin-3-one-containing somatostatin mimetics with a range of sst receptor selectivities. J Med Chem. 2009 Jan 8;52(1):95-104. DMZGFE8 RU https://pubmed.ncbi.nlm.nih.gov/19067538 DMHAJC1 DI DMHAJC1 DMHAJC1 DN PU24S DMHAJC1 MI TT78R5H DMHAJC1 MN Heat shock protein 90 alpha (HSP90A) DMHAJC1 MT DTT DMHAJC1 MA Inhibitor DMHAJC1 RN Recent advances in Hsp90 inhibitors as antitumor agents. Anticancer Agents Med Chem. 2008 Oct;8(7):761-82. DMHAJC1 RU https://pubmed.ncbi.nlm.nih.gov/18855578 DM4SGVF DI DM4SGVF DM4SGVF DN PUKATEINE DM4SGVF MI TTZFYLI DM4SGVF MN Dopamine D1 receptor (D1R) DM4SGVF MT DTT DM4SGVF MA Inhibitor DM4SGVF RN Advances in development of dopaminergic aporphinoids. J Med Chem. 2007 Jan 25;50(2):171-81. DM4SGVF RU https://pubmed.ncbi.nlm.nih.gov/17228858 DM4SGVF DI DM4SGVF DM4SGVF DN PUKATEINE DM4SGVF MI TTEX248 DM4SGVF MN Dopamine D2 receptor (D2R) DM4SGVF MT DTT DM4SGVF MA Inhibitor DM4SGVF RN Advances in development of dopaminergic aporphinoids. J Med Chem. 2007 Jan 25;50(2):171-81. DM4SGVF RU https://pubmed.ncbi.nlm.nih.gov/17228858 DMY2F6T DI DMY2F6T DMY2F6T DN Pumiliotoxin 251D DMY2F6T MI TT0IHXV DMY2F6T MN DNA topoisomerase II (TOP2) DMY2F6T MT DTT DMY2F6T MA Inhibitor DMY2F6T RN How many modes of action should an antibiotic have Curr Opin Pharmacol. 2008 Oct;8(5):564-73. DMY2F6T RU https://pubmed.ncbi.nlm.nih.gov/18621146 DMY2F6T DI DMY2F6T DMY2F6T DN Pumiliotoxin 251D DMY2F6T MI TT1WJCI DMY2F6T MN Streptococcus Topoisomerase IV A (Stre-coc parC) DMY2F6T MT DTT DMY2F6T MA Inhibitor DMY2F6T RN How many modes of action should an antibiotic have Curr Opin Pharmacol. 2008 Oct;8(5):564-73. DMY2F6T RU https://pubmed.ncbi.nlm.nih.gov/18621146 DM7CWQY DI DM7CWQY DM7CWQY DN PUNICAFOLIN DM7CWQY MI TTFJ8Q1 DM7CWQY MN Protein kinase C alpha (PRKCA) DM7CWQY MT DTT DM7CWQY MA Inhibitor DM7CWQY RN Tannins as selective inhibitors of protein kinase C, Bioorg. Med. Chem. Lett. 2(3):239-244 (1992). DM7CWQY RU http://www.sciencedirect.com/science/article/pii/S0960894X01810726 DM7CWQY DI DM7CWQY DM7CWQY DN PUNICAFOLIN DM7CWQY MI TTYPXQF DM7CWQY MN Protein kinase C beta (PRKCB) DM7CWQY MT DTT DM7CWQY MA Inhibitor DM7CWQY RN Tannins as selective inhibitors of protein kinase C, Bioorg. Med. Chem. Lett. 2(3):239-244 (1992). DM7CWQY RU http://www.sciencedirect.com/science/article/pii/S0960894X01810726 DMCWT4L DI DMCWT4L DMCWT4L DN PUP-1 DMCWT4L MI TTXZ0KQ DMCWT4L MN Matrix metalloproteinase-12 (MMP-12) DMCWT4L MT DTT DMCWT4L MA Inhibitor DMCWT4L RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1636). DMCWT4L RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1636 DMHNS0V DI DMHNS0V DMHNS0V DN Purine Riboside DMHNS0V MI TTLP57V DMHNS0V MN Adenosine deaminase (ADA) DMHNS0V MT DTT DMHNS0V MA Inhibitor DMHNS0V RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMHNS0V RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMYWRL6 DI DMYWRL6 DMYWRL6 DN Purpurin DMYWRL6 MI TT5FH9Y DMYWRL6 MN Human immunodeficiency virus Integrase (HIV IN) DMYWRL6 MT DTT DMYWRL6 MA Inhibitor DMYWRL6 RN Identification of HIV-1 integrase inhibitors based on a four-point pharmacophore. Antivir Chem Chemother. 1998 Nov;9(6):461-72. DMYWRL6 RU https://pubmed.ncbi.nlm.nih.gov/9865384 DMNQ7TM DI DMNQ7TM DMNQ7TM DN Purvalanol A DMNQ7TM MI TTAMQ62 DMNQ7TM MN Cyclin A2 (CCNA2) DMNQ7TM MT DTT DMNQ7TM MA Inhibitor DMNQ7TM RN The selectivity of protein kinase inhibitors: a further update. Biochem J. 2007 Dec 15;408(3):297-315. DMNQ7TM RU https://pubmed.ncbi.nlm.nih.gov/17850214 DMNQ7TM DI DMNQ7TM DMNQ7TM DN Purvalanol A DMNQ7TM MI TTH6V3D DMNQ7TM MN Cyclin-dependent kinase 1 (CDK1) DMNQ7TM MT DTT DMNQ7TM MA Inhibitor DMNQ7TM RN Down-regulation of survivin in nitric oxide-induced cell growth inhibition and apoptosis of the human lung carcinoma cells. J Biol Chem. 2004 May 7;279(19):20267-76. DMNQ7TM RU https://pubmed.ncbi.nlm.nih.gov/14988404 DMNQ7TM DI DMNQ7TM DMNQ7TM DN Purvalanol A DMNQ7TM MI TT7HF4W DMNQ7TM MN Cyclin-dependent kinase 2 (CDK2) DMNQ7TM MT DTT DMNQ7TM MA Inhibitor DMNQ7TM RN The selectivity of protein kinase inhibitors: a further update. Biochem J. 2007 Dec 15;408(3):297-315. DMNQ7TM RU https://pubmed.ncbi.nlm.nih.gov/17850214 DMF28IU DI DMF28IU DMF28IU DN PUUPEHEDIONE DMF28IU MI TT12ABZ DMF28IU MN Arachidonate 12-lipoxygenase (12-LOX) DMF28IU MT DTT DMF28IU MA Inhibitor DMF28IU RN Using enzyme assays to evaluate the structure and bioactivity of sponge-derived meroterpenes. J Nat Prod. 2009 Oct;72(10):1857-63. DMF28IU RU https://pubmed.ncbi.nlm.nih.gov/19848434 DMF28IU DI DMF28IU DMF28IU DN PUUPEHEDIONE DMF28IU MI TTN9T81 DMF28IU MN Arachidonate 15-lipoxygenase (15-LOX) DMF28IU MT DTT DMF28IU MA Inhibitor DMF28IU RN Using enzyme assays to evaluate the structure and bioactivity of sponge-derived meroterpenes. J Nat Prod. 2009 Oct;72(10):1857-63. DMF28IU RU https://pubmed.ncbi.nlm.nih.gov/19848434 DMF28IU DI DMF28IU DMF28IU DN PUUPEHEDIONE DMF28IU MI TTSJ6Q4 DMF28IU MN LOX-5 messenger RNA (ALOX5 mRNA) DMF28IU MT DTT DMF28IU MA Inhibitor DMF28IU RN Using enzyme assays to evaluate the structure and bioactivity of sponge-derived meroterpenes. J Nat Prod. 2009 Oct;72(10):1857-63. DMF28IU RU https://pubmed.ncbi.nlm.nih.gov/19848434 DMF3BCK DI DMF3BCK DMF3BCK DN PUUPEHENONE DMF3BCK MI TT12ABZ DMF3BCK MN Arachidonate 12-lipoxygenase (12-LOX) DMF3BCK MT DTT DMF3BCK MA Inhibitor DMF3BCK RN Exploring sponge-derived terpenoids for their potency and selectivity against 12-human, 15-human, and 15-soybean lipoxygenases. J Nat Prod. 2003 Feb;66(2):230-5. DMF3BCK RU https://pubmed.ncbi.nlm.nih.gov/12608855 DMF3BCK DI DMF3BCK DMF3BCK DN PUUPEHENONE DMF3BCK MI TTN9T81 DMF3BCK MN Arachidonate 15-lipoxygenase (15-LOX) DMF3BCK MT DTT DMF3BCK MA Inhibitor DMF3BCK RN Using enzyme assays to evaluate the structure and bioactivity of sponge-derived meroterpenes. J Nat Prod. 2009 Oct;72(10):1857-63. DMF3BCK RU https://pubmed.ncbi.nlm.nih.gov/19848434 DMF3BCK DI DMF3BCK DMF3BCK DN PUUPEHENONE DMF3BCK MI TTSJ6Q4 DMF3BCK MN LOX-5 messenger RNA (ALOX5 mRNA) DMF3BCK MT DTT DMF3BCK MA Inhibitor DMF3BCK RN Using enzyme assays to evaluate the structure and bioactivity of sponge-derived meroterpenes. J Nat Prod. 2009 Oct;72(10):1857-63. DMF3BCK RU https://pubmed.ncbi.nlm.nih.gov/19848434 DMRI1LF DI DMRI1LF DMRI1LF DN PV-1019 DMRI1LF MI TT9ABMF DMRI1LF MN Serine/threonine-protein kinase Chk2 (RAD53) DMRI1LF MT DTT DMRI1LF MA Inhibitor DMRI1LF RN Cellular inhibition of checkpoint kinase 2 (Chk2) and potentiation of camptothecins and radiation by the novel Chk2 inhibitor PV1019 [7-nitro-1H-indole-2-carboxylic acid {4-[1-(guanidinohydrazone)-ethyl]-phenyl}-amide]. J Pharmacol Exp Ther. 2009 Dec;331(3):816-26. DMRI1LF RU https://pubmed.ncbi.nlm.nih.gov/19741151 DM9JYF3 DI DM9JYF3 DM9JYF3 DN PX-12 DM9JYF3 MI TTNHMO8 DM9JYF3 MN COVID-19 papain-like proteinase (PL-PRO) DM9JYF3 MT DTT DM9JYF3 MA Inhibitor DM9JYF3 RN Structure of Mpro from COVID-19 virus and discovery of its inhibitors. Nature. 2020 Apr 9. DM9JYF3 RU https://pubmed.ncbi.nlm.nih.gov/32272481 DMHCEOU DI DMHCEOU DMHCEOU DN PXS-4159 DMHCEOU MI TT7HC21 DMHCEOU MN Membrane copper amine oxidase (AOC3) DMHCEOU MT DTT DMHCEOU MA Inhibitor DMHCEOU RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2767). DMHCEOU RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2767 DM2P0I4 DI DM2P0I4 DM2P0I4 DN PXVX-0103 DM2P0I4 MI TTF4CAM DM2P0I4 MN Influenza Hemagglutinin (Influ HA) DM2P0I4 MT DTT DM2P0I4 MA Modulator DM2P0I4 RN Company report (PaxVax) DM2P0I4 RU http://paxvax.com/other-diseases/h5n1-avian-influenza DMLFJHE DI DMLFJHE DMLFJHE DN Pycnogenol DMLFJHE MI TTSXVID DMLFJHE MN Nuclear factor NF-kappa-B (NFKB) DMLFJHE MT DTT DMLFJHE MA Inhibitor DMLFJHE RN Inhibition mechanisms of bioflavonoids extracted from the bark of Pinus maritima on the expression of proinflammatory cytokines. Ann N Y Acad Sci. 2001 Apr;928:141-56. DMLFJHE RU https://pubmed.ncbi.nlm.nih.gov/11795505 DM3VNYQ DI DM3VNYQ DM3VNYQ DN Pyr3 DM3VNYQ MI TTNVC34 DM3VNYQ MN Short transient receptor potential channel 3 (TRPC3) DM3VNYQ MT DTT DM3VNYQ MA Blocker (channel blocker) DM3VNYQ RN Selective and direct inhibition of TRPC3 channels underlies biological activities of a pyrazole compound. Proc Natl Acad Sci U S A. 2009 Mar 31;106(13):5400-5. DM3VNYQ RU https://pubmed.ncbi.nlm.nih.gov/19289841 DMIZB81 DI DMIZB81 DMIZB81 DN Pyrazine-2-carboxylic acid adamantan-1-ylamide DMIZB81 MI TTVBPDM DMIZB81 MN Metabotropic glutamate receptor 1 (mGluR1) DMIZB81 MT DTT DMIZB81 MA Inhibitor DMIZB81 RN Positive and negative modulation of group I metabotropic glutamate receptors. J Med Chem. 2008 Feb 14;51(3):634-47. DMIZB81 RU https://pubmed.ncbi.nlm.nih.gov/18173231 DMVJLSM DI DMVJLSM DMVJLSM DN Pyrazofurin DMVJLSM MI TTAFJUD DMVJLSM MN Orotidine 5'-monophosphate decarboxylase (UMPS) DMVJLSM MT DTT DMVJLSM MA Inhibitor DMVJLSM RN Molecular approaches for the treatment of hemorrhagic fever virus infections. Antiviral Res. 1993 Sep;22(1):45-75. DMVJLSM RU https://pubmed.ncbi.nlm.nih.gov/8250543 DMUB0EJ DI DMUB0EJ DMUB0EJ DN Pyrazolo[1,5-a]pyrimidine 3G DMUB0EJ MI TTUTJGQ DMUB0EJ MN Vascular endothelial growth factor receptor 2 (KDR) DMUB0EJ MT DTT DMUB0EJ MA Inhibitor DMUB0EJ RN Optimization of a pyrazolo[1,5-a]pyrimidine class of KDR kinase inhibitors: improvements in physical properties enhance cellular activity and pharm... Bioorg Med Chem Lett. 2002 Dec 16;12(24):3537-41. DMUB0EJ RU https://pubmed.ncbi.nlm.nih.gov/12443771 DM69LKB DI DM69LKB DM69LKB DN Pyrazolo[1,5-a]pyrimidine-3-carboxylate DM69LKB MI TT0EOB8 DM69LKB MN B-Raf messenger RNA (BRAF mRNA) DM69LKB MT DTT DM69LKB MA Inhibitor DM69LKB RN Identification of pyrazolo[1,5-a]pyrimidine-3-carboxylates as B-Raf kinase inhibitors. Bioorg Med Chem Lett. 2009 May 15;19(10):2735-8. DM69LKB RU https://pubmed.ncbi.nlm.nih.gov/19362830 DMLFQKU DI DMLFQKU DMLFQKU DN pyrazolone, 1 DMLFQKU MI TTOJ1NF DMLFQKU MN FMLP-related receptor I (FPR2) DMLFQKU MT DTT DMLFQKU MA Agonist DMLFQKU RN Potent hFPRL1 (ALXR) agonists as potential anti-inflammatory agents. Bioorg Med Chem Lett. 2006 Jul 15;16(14):3713-8. DMLFQKU RU https://pubmed.ncbi.nlm.nih.gov/16697190 DMLFQKU DI DMLFQKU DMLFQKU DN pyrazolone, 1 DMLFQKU MI TT5Y4EM DMLFQKU MN N-formyl peptide receptor (FPR1) DMLFQKU MT DTT DMLFQKU MA Agonist DMLFQKU RN Functional characterization of three mouse formyl peptide receptors. Mol Pharmacol. 2013 Feb;83(2):389-98. DMLFQKU RU https://pubmed.ncbi.nlm.nih.gov/23160941 DMKTB5U DI DMKTB5U DMKTB5U DN PYRAZOLOPYRIDAZINE 1 DMKTB5U MI TT7HF4W DMKTB5U MN Cyclin-dependent kinase 2 (CDK2) DMKTB5U MT DTT DMKTB5U MA Inhibitor DMKTB5U RN N-Phenyl-4-pyrazolo[1,5-b]pyridazin-3-ylpyrimidin-2-amines as potent and selective inhibitors of glycogen synthase kinase 3 with good cellular effi... J Med Chem. 2004 Sep 9;47(19):4716-30. DMKTB5U RU https://pubmed.ncbi.nlm.nih.gov/15341487 DMKTB5U DI DMKTB5U DMKTB5U DN PYRAZOLOPYRIDAZINE 1 DMKTB5U MI TT0PG8F DMKTB5U MN Cyclin-dependent kinase 4 (CDK4) DMKTB5U MT DTT DMKTB5U MA Inhibitor DMKTB5U RN N-Phenyl-4-pyrazolo[1,5-b]pyridazin-3-ylpyrimidin-2-amines as potent and selective inhibitors of glycogen synthase kinase 3 with good cellular effi... J Med Chem. 2004 Sep 9;47(19):4716-30. DMKTB5U RU https://pubmed.ncbi.nlm.nih.gov/15341487 DMKTB5U DI DMKTB5U DMKTB5U DN PYRAZOLOPYRIDAZINE 1 DMKTB5U MI TTRSMW9 DMKTB5U MN Glycogen synthase kinase-3 beta (GSK-3B) DMKTB5U MT DTT DMKTB5U MA Inhibitor DMKTB5U RN N-Phenyl-4-pyrazolo[1,5-b]pyridazin-3-ylpyrimidin-2-amines as potent and selective inhibitors of glycogen synthase kinase 3 with good cellular effi... J Med Chem. 2004 Sep 9;47(19):4716-30. DMKTB5U RU https://pubmed.ncbi.nlm.nih.gov/15341487 DMI7AUJ DI DMI7AUJ DMI7AUJ DN PYRAZOLOPYRIDAZINE 2 DMI7AUJ MI TT7HF4W DMI7AUJ MN Cyclin-dependent kinase 2 (CDK2) DMI7AUJ MT DTT DMI7AUJ MA Inhibitor DMI7AUJ RN N-Phenyl-4-pyrazolo[1,5-b]pyridazin-3-ylpyrimidin-2-amines as potent and selective inhibitors of glycogen synthase kinase 3 with good cellular effi... J Med Chem. 2004 Sep 9;47(19):4716-30. DMI7AUJ RU https://pubmed.ncbi.nlm.nih.gov/15341487 DMI7AUJ DI DMI7AUJ DMI7AUJ DN PYRAZOLOPYRIDAZINE 2 DMI7AUJ MI TT0PG8F DMI7AUJ MN Cyclin-dependent kinase 4 (CDK4) DMI7AUJ MT DTT DMI7AUJ MA Inhibitor DMI7AUJ RN N-Phenyl-4-pyrazolo[1,5-b]pyridazin-3-ylpyrimidin-2-amines as potent and selective inhibitors of glycogen synthase kinase 3 with good cellular effi... J Med Chem. 2004 Sep 9;47(19):4716-30. DMI7AUJ RU https://pubmed.ncbi.nlm.nih.gov/15341487 DMI7AUJ DI DMI7AUJ DMI7AUJ DN PYRAZOLOPYRIDAZINE 2 DMI7AUJ MI TTRSMW9 DMI7AUJ MN Glycogen synthase kinase-3 beta (GSK-3B) DMI7AUJ MT DTT DMI7AUJ MA Inhibitor DMI7AUJ RN N-Phenyl-4-pyrazolo[1,5-b]pyridazin-3-ylpyrimidin-2-amines as potent and selective inhibitors of glycogen synthase kinase 3 with good cellular effi... J Med Chem. 2004 Sep 9;47(19):4716-30. DMI7AUJ RU https://pubmed.ncbi.nlm.nih.gov/15341487 DMEF6IP DI DMEF6IP DMEF6IP DN Pyrene-1-aldehyde DMEF6IP MI DEM1HNL DMEF6IP MN Alcohol dehydrogenase class-I gamma (ADH1C) DMEF6IP MT DME DMEF6IP MA Metabolism DMEF6IP RN Oxidation of alcohols and reduction of aldehydes derived from methyl- and dimethylpyrenes by cDNA-expressed human alcohol dehydrogenases. Toxicology. 2008 Mar 12;245(1-2):65-75. DMEF6IP RU https://www.ncbi.nlm.nih.gov/pubmed/?term=18242813 DMEF6IP DI DMEF6IP DMEF6IP DN Pyrene-1-aldehyde DMEF6IP MI DEOCWU3 DMEF6IP MN Alcohol dehydrogenase class-II (ADH4) DMEF6IP MT DME DMEF6IP MA Metabolism DMEF6IP RN Oxidation of alcohols and reduction of aldehydes derived from methyl- and dimethylpyrenes by cDNA-expressed human alcohol dehydrogenases. Toxicology. 2008 Mar 12;245(1-2):65-75. DMEF6IP RU https://www.ncbi.nlm.nih.gov/pubmed/?term=18242813 DMGJ0RM DI DMGJ0RM DMGJ0RM DN Pyrenemethanol DMGJ0RM MI DEM1HNL DMGJ0RM MN Alcohol dehydrogenase class-I gamma (ADH1C) DMGJ0RM MT DME DMGJ0RM MA Metabolism DMGJ0RM RN Oxidation of alcohols and reduction of aldehydes derived from methyl- and dimethylpyrenes by cDNA-expressed human alcohol dehydrogenases. Toxicology. 2008 Mar 12;245(1-2):65-75. DMGJ0RM RU https://www.ncbi.nlm.nih.gov/pubmed/?term=18242813 DMGJ0RM DI DMGJ0RM DMGJ0RM DN Pyrenemethanol DMGJ0RM MI DEOCWU3 DMGJ0RM MN Alcohol dehydrogenase class-II (ADH4) DMGJ0RM MT DME DMGJ0RM MA Metabolism DMGJ0RM RN Oxidation of alcohols and reduction of aldehydes derived from methyl- and dimethylpyrenes by cDNA-expressed human alcohol dehydrogenases. Toxicology. 2008 Mar 12;245(1-2):65-75. DMGJ0RM RU https://www.ncbi.nlm.nih.gov/pubmed/?term=18242813 DMOCG6M DI DMOCG6M DMOCG6M DN Pyridin-3-yl 4-butoxybenzylcarbamate DMOCG6M MI TTDP1UC DMOCG6M MN Fatty acid amide hydrolase (FAAH) DMOCG6M MT DTT DMOCG6M MA Inhibitor DMOCG6M RN Oxime carbamate--discovery of a series of novel FAAH inhibitors. Bioorg Med Chem Lett. 2010 Feb 1;20(3):1272-7. DMOCG6M RU https://pubmed.ncbi.nlm.nih.gov/20036536 DM4G8WX DI DM4G8WX DM4G8WX DN Pyridine-2,4-dicarboxylic acid DM4G8WX MI TTMHFRY DM4G8WX MN HIF-prolyl hydroxylase 1 (HPH-1) DM4G8WX MT DTT DM4G8WX MA Inhibitor DM4G8WX RN Design, synthesis, enzyme-inhibitory activity, and effect on human cancer cells of a novel series of jumonji domain-containing protein 2 histone de... J Med Chem. 2010 Aug 12;53(15):5629-38. DM4G8WX RU https://pubmed.ncbi.nlm.nih.gov/20684604 DM3PAS4 DI DM3PAS4 DM3PAS4 DN Pyridobenzimidazole DM3PAS4 MI TTZMS1L DM3PAS4 MN Fungal Papulacandin B resistance protein 1 (Fung FKS1) DM3PAS4 MT DTT DM3PAS4 MA Inhibitor DM3PAS4 RN Novel antifungal agents, targets or therapeutic strategies for the treatment of invasive fungal diseases: a review of the literature (2005-2009). Rev Iberoam Micol. 2009 Mar 31;26(1):15-22. DM3PAS4 RU https://pubmed.ncbi.nlm.nih.gov/19463273 DMQ6POC DI DMQ6POC DMQ6POC DN Pyridoxamine-5'-Phosphate DMQ6POC MI TTF9OQ6 DMQ6POC MN Branched-chain-amino-acid transaminase 2 (BCAT2) DMQ6POC MT DTT DMQ6POC MA Inhibitor DMQ6POC RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMQ6POC RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMQ6POC DI DMQ6POC DMQ6POC DN Pyridoxamine-5'-Phosphate DMQ6POC MI TT6TMZU DMQ6POC MN Mycobacterium Biosynthetic alanine racemase (MycB alr) DMQ6POC MT DTT DMQ6POC MA Inhibitor DMQ6POC RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMQ6POC RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMQ6POC DI DMQ6POC DMQ6POC DN Pyridoxamine-5'-Phosphate DMQ6POC MI TTN6GE9 DMQ6POC MN Staphylococcus D-amino acid aminotransferase (Stap-coc dat) DMQ6POC MT DTT DMQ6POC MA Inhibitor DMQ6POC RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMQ6POC RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMFUNL1 DI DMFUNL1 DMFUNL1 DN Pyridoxine-5'-phosphate DMFUNL1 MI TTHB48R DMFUNL1 MN Bacterial Pyridoxal phosphate biosynthetic pdxJ (Bact pdxJ) DMFUNL1 MT DTT DMFUNL1 MA Inhibitor DMFUNL1 RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMFUNL1 RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMFUNL1 DI DMFUNL1 DMFUNL1 DN Pyridoxine-5'-phosphate DMFUNL1 MI TTUMGNO DMFUNL1 MN Ornithine decarboxylase (ODC1) DMFUNL1 MT DTT DMFUNL1 MA Inhibitor DMFUNL1 RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMFUNL1 RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMFUNL1 DI DMFUNL1 DMFUNL1 DN Pyridoxine-5'-phosphate DMFUNL1 MI DE3Z1RA DMFUNL1 MN Pyridoxamine-phosphate oxidase (PNPO) DMFUNL1 MT DME DMFUNL1 MA Metabolism DMFUNL1 RN Pyridoxine 5'-phosphate oxidase is a novel therapeutic target and regulated by the TGF-beta signalling pathway in epithelial ovarian cancer. Cell Death Dis. 2017 Dec 13;8(12):3214. DMFUNL1 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=29238081 DMUVCWY DI DMUVCWY DMUVCWY DN Pyridoxyl-Alanine-5-Phosphate DMUVCWY MI TT6TMZU DMUVCWY MN Mycobacterium Biosynthetic alanine racemase (MycB alr) DMUVCWY MT DTT DMUVCWY MA Inhibitor DMUVCWY RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMUVCWY RU https://pubmed.ncbi.nlm.nih.gov/17139284 DM7AW0X DI DM7AW0X DM7AW0X DN Pyridoxyl-N,O-Cycloserylamide-5-Monophosphate DM7AW0X MI TT6TMZU DM7AW0X MN Mycobacterium Biosynthetic alanine racemase (MycB alr) DM7AW0X MT DTT DM7AW0X MA Inhibitor DM7AW0X RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DM7AW0X RU https://pubmed.ncbi.nlm.nih.gov/17139284 DM7T2VQ DI DM7T2VQ DM7T2VQ DN Pyrimidinyl acylthiourea DM7T2VQ MI TTSUKYD DM7T2VQ MN Virus RNA-dependent RNA polymerase (Viru RdRP) DM7T2VQ MT DTT DM7T2VQ MA Inhibitor DM7T2VQ RN Activity of T-705 in a hamster model of yellow fever virus infection in comparison with that of a chemically related compound, T-1106. Antimicrob Agents Chemother. 2009 Jan;53(1):202-9. DM7T2VQ RU https://pubmed.ncbi.nlm.nih.gov/18955536 DMCTJAM DI DMCTJAM DMCTJAM DN PYRIPYROPENE A DMCTJAM MI TTMF541 DMCTJAM MN Liver carboxylesterase (CES1) DMCTJAM MT DTT DMCTJAM MA Inhibitor DMCTJAM RN Acyl-CoA: cholesterol acyltransferase inhibitory activities of fatty acid amides isolated from Mylabris phalerate Pallas. Bioorg Med Chem Lett. 2004 Aug 16;14(16):4277-80. DMCTJAM RU https://pubmed.ncbi.nlm.nih.gov/15261286 DMCTJAM DI DMCTJAM DMCTJAM DN PYRIPYROPENE A DMCTJAM MI TTAK0IN DMCTJAM MN SOAT2 messenger RNA (SOAT2 mRNA) DMCTJAM MT DTT DMCTJAM MA Inhibitor DMCTJAM RN Saucerneol B derivatives as human acyl-CoA: cholesterol acyltransferase inhibitors. Bioorg Med Chem Lett. 2005 Jan 17;15(2):385-8. DMCTJAM RU https://pubmed.ncbi.nlm.nih.gov/15603959 DMG5KDY DI DMG5KDY DMG5KDY DN Pyrogallol DMG5KDY MI TT2J34L DMG5KDY MN Arachidonate 5-lipoxygenase (5-LOX) DMG5KDY MT DTT DMG5KDY MA Inhibitor DMG5KDY RN Simple analogues of anthralin: unusual specificity of structure and antiproliferative activity. J Med Chem. 1997 Nov 7;40(23):3773-80. DMG5KDY RU https://pubmed.ncbi.nlm.nih.gov/9371243 DMG5KDY DI DMG5KDY DMG5KDY DN Pyrogallol DMG5KDY MI DEWRN24 DMG5KDY MN Glucansucrase (gtf106B) DMG5KDY MT DME DMG5KDY MA Metabolism DMG5KDY RN Impact of low-level laser therapy on hyposalivation, salivary pH, and quality of life in head and neck cancer patients post-radiotherapy. Lasers Med Sci. 2017 May;32(4):827-832. DMG5KDY RU https://pubmed.ncbi.nlm.nih.gov/28258315 DMROZUA DI DMROZUA DMROZUA DN Pyroglutamic acid DMROZUA MI TTURHFP DMROZUA MN Angiogenin (ANG) DMROZUA MT DTT DMROZUA MA Inhibitor DMROZUA RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMROZUA RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMROZUA DI DMROZUA DMROZUA DN Pyroglutamic acid DMROZUA MI DT342ZG DMROZUA MN Monocarboxylate transporter 1 (SLC16A1) DMROZUA MT DTP DMROZUA MA Substrate DMROZUA RN Interaction of atorvastatin with the human glial transporter SLC16A1. Eur J Pharmacol. 2016 Oct 5;788:248-254. DMROZUA RU http://www.ncbi.nlm.nih.gov/pubmed/27341998 DMROZUA DI DMROZUA DMROZUA DN Pyroglutamic acid DMROZUA MI TTU5HJP DMROZUA MN Orexin (HCRT) DMROZUA MT DTT DMROZUA MA Inhibitor DMROZUA RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMROZUA RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMROZUA DI DMROZUA DMROZUA DN Pyroglutamic acid DMROZUA MI TTCGSZ4 DMROZUA MN Pancreatic alpha-amylase (AMY2A) DMROZUA MT DTT DMROZUA MA Inhibitor DMROZUA RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMROZUA RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMZQ75M DI DMZQ75M DMZQ75M DN Pyrophosphate 2- DMZQ75M MI TTURHFP DMZQ75M MN Angiogenin (ANG) DMZQ75M MT DTT DMZQ75M MA Inhibitor DMZQ75M RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DMZQ75M RU https://pubmed.ncbi.nlm.nih.gov/10592235 DMZQ75M DI DMZQ75M DMZQ75M DN Pyrophosphate 2- DMZQ75M MI TT8WCXO DMZQ75M MN Bacterial NH(3)-dependent NAD(+) synthetase (Bact nadE) DMZQ75M MT DTT DMZQ75M MA Inhibitor DMZQ75M RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DMZQ75M RU https://pubmed.ncbi.nlm.nih.gov/10592235 DMZQ75M DI DMZQ75M DMZQ75M DN Pyrophosphate 2- DMZQ75M MI TTCFP0V DMZQ75M MN Glutamine amidotransferase (GMPS) DMZQ75M MT DTT DMZQ75M MA Inhibitor DMZQ75M RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DMZQ75M RU https://pubmed.ncbi.nlm.nih.gov/10592235 DMZQ75M DI DMZQ75M DMZQ75M DN Pyrophosphate 2- DMZQ75M MI TTZ3IFB DMZQ75M MN Phosphogluconate dehydrogenase (PGD) DMZQ75M MT DTT DMZQ75M MA Inhibitor DMZQ75M RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DMZQ75M RU https://pubmed.ncbi.nlm.nih.gov/10592235 DMZQ75M DI DMZQ75M DMZQ75M DN Pyrophosphate 2- DMZQ75M MI TTBL49X DMZQ75M MN Plasmodium Hypoxanthine-guanine phosphoribosyltransferase (Malaria LACZ) DMZQ75M MT DTT DMZQ75M MA Inhibitor DMZQ75M RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DMZQ75M RU https://pubmed.ncbi.nlm.nih.gov/10592235 DMZQ75M DI DMZQ75M DMZQ75M DN Pyrophosphate 2- DMZQ75M MI TTOY91U DMZQ75M MN Plasmodium Hypoxanthine-guanine-xanthine phosphoribosyltransferase (Malaria LACZ) DMZQ75M MT DTT DMZQ75M MA Inhibitor DMZQ75M RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DMZQ75M RU https://pubmed.ncbi.nlm.nih.gov/10592235 DMZQ75M DI DMZQ75M DMZQ75M DN Pyrophosphate 2- DMZQ75M MI TTSUKYD DMZQ75M MN Virus RNA-dependent RNA polymerase (Viru RdRP) DMZQ75M MT DTT DMZQ75M MA Inhibitor DMZQ75M RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DMZQ75M RU https://pubmed.ncbi.nlm.nih.gov/10592235 DMV48S2 DI DMV48S2 DMV48S2 DN Pyrovalerone DMV48S2 MI TTVBI8W DMV48S2 MN Dopamine transporter (DAT) DMV48S2 MT DTT DMV48S2 MA Inhibitor DMV48S2 RN A novel photoaffinity ligand for the dopamine transporter based on pyrovalerone. Bioorg Med Chem. 2009 Jun 1;17(11):3770-4. DMV48S2 RU https://pubmed.ncbi.nlm.nih.gov/19442525 DMV48S2 DI DMV48S2 DMV48S2 DN Pyrovalerone DMV48S2 MI TTAWNKZ DMV48S2 MN Norepinephrine transporter (NET) DMV48S2 MT DTT DMV48S2 MA Inhibitor DMV48S2 RN 1-(4-Methylphenyl)-2-pyrrolidin-1-yl-pentan-1-one (Pyrovalerone) analogues: a promising class of monoamine uptake inhibitors. J Med Chem. 2006 Feb 23;49(4):1420-32. DMV48S2 RU https://pubmed.ncbi.nlm.nih.gov/16480278 DMV48S2 DI DMV48S2 DMV48S2 DN Pyrovalerone DMV48S2 MI TT3ROYC DMV48S2 MN Serotonin transporter (SERT) DMV48S2 MT DTT DMV48S2 MA Inhibitor DMV48S2 RN 1-(4-Methylphenyl)-2-pyrrolidin-1-yl-pentan-1-one (Pyrovalerone) analogues: a promising class of monoamine uptake inhibitors. J Med Chem. 2006 Feb 23;49(4):1420-32. DMV48S2 RU https://pubmed.ncbi.nlm.nih.gov/16480278 DMS4ZFU DI DMS4ZFU DMS4ZFU DN Pyrrolidin-(2Z)-ylideneamine DMS4ZFU MI TTZUFI5 DMS4ZFU MN Nitric-oxide synthase brain (NOS1) DMS4ZFU MT DTT DMS4ZFU MA Inhibitor DMS4ZFU RN Evaluation of pyrrolidin-2-imines and 1,3-thiazolidin-2-imines as inhibitors of nitric oxide synthase. Bioorg Med Chem Lett. 2004 Sep 6;14(17):4539-44. DMS4ZFU RU https://pubmed.ncbi.nlm.nih.gov/15357988 DMS4ZFU DI DMS4ZFU DMS4ZFU DN Pyrrolidin-(2Z)-ylideneamine DMS4ZFU MI TTCM4B3 DMS4ZFU MN Nitric-oxide synthase endothelial (NOS3) DMS4ZFU MT DTT DMS4ZFU MA Inhibitor DMS4ZFU RN Evaluation of pyrrolidin-2-imines and 1,3-thiazolidin-2-imines as inhibitors of nitric oxide synthase. Bioorg Med Chem Lett. 2004 Sep 6;14(17):4539-44. DMS4ZFU RU https://pubmed.ncbi.nlm.nih.gov/15357988 DMS4ZFU DI DMS4ZFU DMS4ZFU DN Pyrrolidin-(2Z)-ylideneamine DMS4ZFU MI TTF10I9 DMS4ZFU MN Nitric-oxide synthase inducible (NOS2) DMS4ZFU MT DTT DMS4ZFU MA Inhibitor DMS4ZFU RN Evaluation of pyrrolidin-2-imines and 1,3-thiazolidin-2-imines as inhibitors of nitric oxide synthase. Bioorg Med Chem Lett. 2004 Sep 6;14(17):4539-44. DMS4ZFU RU https://pubmed.ncbi.nlm.nih.gov/15357988 DMYNZXC DI DMYNZXC DMYNZXC DN Pyrrolidin-1-yl-thiourea DMYNZXC MI TTMI6F5 DMYNZXC MN Transient receptor potential cation channel V1 (TRPV1) DMYNZXC MT DTT DMYNZXC MA Inhibitor DMYNZXC RN N-4-methansulfonamidobenzyl-N'-2-substituted-4-tert-butyl-benzyl thioureas as potent vanilloid receptor antagonistic ligands. Bioorg Med Chem Lett. 2004 Apr 5;14(7):1693-6. DMYNZXC RU https://pubmed.ncbi.nlm.nih.gov/15026052 DMYNZXC DI DMYNZXC DMYNZXC DN Pyrrolidin-1-yl-thiourea DMYNZXC MI TTKP2SU DMYNZXC MN Transient receptor potential cation channel V4 (TRPV4) DMYNZXC MT DTT DMYNZXC MA Inhibitor DMYNZXC RN N-4-methansulfonamidobenzyl-N'-2-substituted-4-tert-butyl-benzyl thioureas as potent vanilloid receptor antagonistic ligands. Bioorg Med Chem Lett. 2004 Apr 5;14(7):1693-6. DMYNZXC RU https://pubmed.ncbi.nlm.nih.gov/15026052 DM0BHCJ DI DM0BHCJ DM0BHCJ DN Pyrrolidin-3-yl-acetic acid DM0BHCJ MI TT1MPAY DM0BHCJ MN GABA(A) receptor alpha-1 (GABRA1) DM0BHCJ MT DTT DM0BHCJ MA Inhibitor DM0BHCJ RN Orally active and potent inhibitors of gamma-aminobutyric acid uptake. J Med Chem. 1985 May;28(5):653-60. DM0BHCJ RU https://pubmed.ncbi.nlm.nih.gov/2985785 DM0BHCJ DI DM0BHCJ DM0BHCJ DN Pyrrolidin-3-yl-acetic acid DM0BHCJ MI TTNJYV2 DM0BHCJ MN Gamma-aminobutyric acid receptor (GAR) DM0BHCJ MT DTT DM0BHCJ MA Inhibitor DM0BHCJ RN Orally active and potent inhibitors of gamma-aminobutyric acid uptake. J Med Chem. 1985 May;28(5):653-60. DM0BHCJ RU https://pubmed.ncbi.nlm.nih.gov/2985785 DM5ZAS6 DI DM5ZAS6 DM5ZAS6 DN Pyrrolidine dithiocarbamate DM5ZAS6 MI TTSXVID DM5ZAS6 MN Nuclear factor NF-kappa-B (NFKB) DM5ZAS6 MT DTT DM5ZAS6 MA Inhibitor DM5ZAS6 RN Simulated ischemia induces renal tubular cell apoptosis through a nuclear factor-kappaB dependent mechanism. J Urol. 2002 Jul;168(1):248-52. DM5ZAS6 RU https://pubmed.ncbi.nlm.nih.gov/12050551 DME6HCQ DI DME6HCQ DME6HCQ DN pyrrolidine MCHR1 antagonist 1 DME6HCQ MI TTX4RTB DME6HCQ MN Melanin-concentrating hormone receptor 1 (MCHR1) DME6HCQ MT DTT DME6HCQ MA Antagonist DME6HCQ RN Novel pyrrolidine melanin-concentrating hormone receptor 1 antagonists with reduced hERG inhibition. Bioorg Med Chem Lett. 2011 Apr 15;21(8):2460-7. DME6HCQ RU https://pubmed.ncbi.nlm.nih.gov/21414780 DM906JK DI DM906JK DM906JK DN Pyrrolidine-1-carbonitrile DM906JK MI TTDZN01 DM906JK MN Cathepsin K (CTSK) DM906JK MT DTT DM906JK MA Inhibitor DM906JK RN Acyclic cyanamide-based inhibitors of cathepsin K. Bioorg Med Chem Lett. 2005 Jun 15;15(12):3039-43. DM906JK RU https://pubmed.ncbi.nlm.nih.gov/15896958 DM1X5JR DI DM1X5JR DM1X5JR DN Pyrrolo[3,4-c]carbazole-1,3(2H,6H)-dione DM1X5JR MI TTVDSZ0 DM1X5JR MN Poly [ADP-ribose] polymerase 1 (PARP1) DM1X5JR MT DTT DM1X5JR MA Inhibitor DM1X5JR RN Synthesis and structure-activity relationships of novel poly(ADP-ribose) polymerase-1 inhibitors. Bioorg Med Chem Lett. 2006 Feb 15;16(4):938-42. DM1X5JR RU https://pubmed.ncbi.nlm.nih.gov/16290935 DMM4CU9 DI DMM4CU9 DMM4CU9 DN Pyrrolo[3,4-e]indole-1,3(2H,6H)-dione DMM4CU9 MI TTVDSZ0 DMM4CU9 MN Poly [ADP-ribose] polymerase 1 (PARP1) DMM4CU9 MT DTT DMM4CU9 MA Inhibitor DMM4CU9 RN Synthesis and structure-activity relationships of novel poly(ADP-ribose) polymerase-1 inhibitors. Bioorg Med Chem Lett. 2006 Feb 15;16(4):938-42. DMM4CU9 RU https://pubmed.ncbi.nlm.nih.gov/16290935 DMZLFVG DI DMZLFVG DMZLFVG DN Pyrrolopyrimidine DMZLFVG MI TTOI92F DMZLFVG MN Multidrug resistance-associated protein 1 (ABCC1) DMZLFVG MT DTT DMZLFVG MA Inhibitor DMZLFVG RN Topological model for the prediction of MRP1 inhibitory activity of pyrrolopyrimidines and templates derived from pyrrolopyrimidine. Bioorg Med Chem Lett. 2005 Nov 15;15(22):4967-72. DMZLFVG RU https://pubmed.ncbi.nlm.nih.gov/16168641 DMUEKB3 DI DMUEKB3 DMUEKB3 DN pyrrolopyrimidine 48 DMUEKB3 MI TT4G2JS DMUEKB3 MN Voltage-gated sodium channel alpha Nav1.7 (SCN9A) DMUEKB3 MT DTT DMUEKB3 MA Blocker (channel blocker) DMUEKB3 RN Discovery and hit-to-lead optimization of pyrrolopyrimidines as potent, state-dependent Na(v)1.7 antagonists. Bioorg Med Chem Lett. 2012 Mar 1;22(5):2052-62. DMUEKB3 RU https://pubmed.ncbi.nlm.nih.gov/22318156 DM725FL DI DM725FL DM725FL DN PYY(22-36) DM725FL MI TTRK9JT DM725FL MN Neuropeptide Y receptor type 1 (NPY1R) DM725FL MT DTT DM725FL MA Inhibitor DM725FL RN Identification of selective neuropeptide Y2 peptide agonists. Bioorg Med Chem Lett. 2007 Jan 15;17(2):538-41. DM725FL RU https://pubmed.ncbi.nlm.nih.gov/17055726 DM725FL DI DM725FL DM725FL DN PYY(22-36) DM725FL MI TTJ6WK9 DM725FL MN Neuropeptide Y receptor type 2 (NPY2R) DM725FL MT DTT DM725FL MA Inhibitor DM725FL RN Identification of selective neuropeptide Y2 peptide agonists. Bioorg Med Chem Lett. 2007 Jan 15;17(2):538-41. DM725FL RU https://pubmed.ncbi.nlm.nih.gov/17055726 DMD6ZWV DI DMD6ZWV DMD6ZWV DN PYY(25-36) DMD6ZWV MI TTJ6WK9 DMD6ZWV MN Neuropeptide Y receptor type 2 (NPY2R) DMD6ZWV MT DTT DMD6ZWV MA Inhibitor DMD6ZWV RN Identification of selective neuropeptide Y2 peptide agonists. Bioorg Med Chem Lett. 2007 Jan 15;17(2):538-41. DMD6ZWV RU https://pubmed.ncbi.nlm.nih.gov/17055726 DMFUYR1 DI DMFUYR1 DMFUYR1 DN Pyz11-D-Trp8-SRIF DMFUYR1 MI TTZ6T9E DMFUYR1 MN Somatostatin receptor type 2 (SSTR2) DMFUYR1 MT DTT DMFUYR1 MA Inhibitor DMFUYR1 RN Replacement of Phe6, Phe7, and Phe11 of D-Trp8-somatostatin-14 with L-pyrazinylalanine. Predicted and observed effects on binding affinities at hSS... J Med Chem. 2005 Jun 16;48(12):4025-30. DMFUYR1 RU https://pubmed.ncbi.nlm.nih.gov/15943475 DMFUYR1 DI DMFUYR1 DMFUYR1 DN Pyz11-D-Trp8-SRIF DMFUYR1 MI TTAE1BR DMFUYR1 MN Somatostatin receptor type 4 (SSTR4) DMFUYR1 MT DTT DMFUYR1 MA Inhibitor DMFUYR1 RN Replacement of Phe6, Phe7, and Phe11 of D-Trp8-somatostatin-14 with L-pyrazinylalanine. Predicted and observed effects on binding affinities at hSS... J Med Chem. 2005 Jun 16;48(12):4025-30. DMFUYR1 RU https://pubmed.ncbi.nlm.nih.gov/15943475 DMDB3Q8 DI DMDB3Q8 DMDB3Q8 DN Pyz6-D-Trp8-SRIF DMDB3Q8 MI TTZ6T9E DMDB3Q8 MN Somatostatin receptor type 2 (SSTR2) DMDB3Q8 MT DTT DMDB3Q8 MA Inhibitor DMDB3Q8 RN Replacement of Phe6, Phe7, and Phe11 of D-Trp8-somatostatin-14 with L-pyrazinylalanine. Predicted and observed effects on binding affinities at hSS... J Med Chem. 2005 Jun 16;48(12):4025-30. DMDB3Q8 RU https://pubmed.ncbi.nlm.nih.gov/15943475 DMDB3Q8 DI DMDB3Q8 DMDB3Q8 DN Pyz6-D-Trp8-SRIF DMDB3Q8 MI TTAE1BR DMDB3Q8 MN Somatostatin receptor type 4 (SSTR4) DMDB3Q8 MT DTT DMDB3Q8 MA Inhibitor DMDB3Q8 RN Replacement of Phe6, Phe7, and Phe11 of D-Trp8-somatostatin-14 with L-pyrazinylalanine. Predicted and observed effects on binding affinities at hSS... J Med Chem. 2005 Jun 16;48(12):4025-30. DMDB3Q8 RU https://pubmed.ncbi.nlm.nih.gov/15943475 DM9D805 DI DM9D805 DM9D805 DN Pyz7-D-Trp8-SRIF DM9D805 MI TTAE1BR DM9D805 MN Somatostatin receptor type 4 (SSTR4) DM9D805 MT DTT DM9D805 MA Inhibitor DM9D805 RN Replacement of Phe6, Phe7, and Phe11 of D-Trp8-somatostatin-14 with L-pyrazinylalanine. Predicted and observed effects on binding affinities at hSS... J Med Chem. 2005 Jun 16;48(12):4025-30. DM9D805 RU https://pubmed.ncbi.nlm.nih.gov/15943475 DME0NO8 DI DME0NO8 DME0NO8 DN PYZD-4409 DME0NO8 MI TTXHWA7 DME0NO8 MN Ubiquitin-activating enzyme E1 (UBAE1) DME0NO8 MT DTT DME0NO8 MA Inhibitor DME0NO8 RN The ubiquitin-activating enzyme E1 as a therapeutic target for the treatment of leukemia and multiple myeloma. Blood. 2010 Mar 18;115(11):2251-9. DME0NO8 RU https://pubmed.ncbi.nlm.nih.gov/20075161 DML5KMT DI DML5KMT DML5KMT DN Q-27137207 DML5KMT MI DECV2ME DML5KMT MN Cytochrome P450 105D7 (cyp105) DML5KMT MT DME DML5KMT MA Metabolism DML5KMT RN nan DML5KMT RU nan DM26GBV DI DM26GBV DM26GBV DN QA1 DM26GBV MI TTV1C0Z DM26GBV MN Neuropeptide S receptor (NPSR) DM26GBV MT DTT DM26GBV MA Antagonist DM26GBV RN Synthesis and evaluation of a new series of Neuropeptide S receptor antagonists. Bioorg Med Chem Lett. 2010 Aug 1;20(15):4700-3. DM26GBV RU https://pubmed.ncbi.nlm.nih.gov/20510609 DM62PI8 DI DM62PI8 DM62PI8 DN QCP DM62PI8 MI TT2UE56 DM62PI8 MN Sodium/glucose cotransporter 1 (SGLT1) DM62PI8 MT DTT DM62PI8 MA Inhibitor DM62PI8 RN Tripeptides of RS1 (RSC1A1) inhibit a monosaccharide-dependent exocytotic pathway of Na+-D-glucose cotransporter SGLT1 with high affinity. J Biol Chem. 2007 Sep 28;282(39):28501-13. DM62PI8 RU https://pubmed.ncbi.nlm.nih.gov/17686765 DMSMQXZ DI DMSMQXZ DMSMQXZ DN Qcpac DMSMQXZ MI TT2UE56 DMSMQXZ MN Sodium/glucose cotransporter 1 (SGLT1) DMSMQXZ MT DTT DMSMQXZ MA Inhibitor DMSMQXZ RN Tripeptides of RS1 (RSC1A1) inhibit a monosaccharide-dependent exocytotic pathway of Na+-D-glucose cotransporter SGLT1 with high affinity. J Biol Chem. 2007 Sep 28;282(39):28501-13. DMSMQXZ RU https://pubmed.ncbi.nlm.nih.gov/17686765 DMJ38YV DI DMJ38YV DMJ38YV DN QEDIIRNIARHLAQVGDSMDR DMJ38YV MI TTJGNVC DMJ38YV MN Apoptosis regulator Bcl-2 (BCL-2) DMJ38YV MT DTT DMJ38YV MA Inhibitor DMJ38YV RN Structure-based design of potent small-molecule inhibitors of anti-apoptotic Bcl-2 proteins. J Med Chem. 2006 Oct 19;49(21):6139-42. DMJ38YV RU https://pubmed.ncbi.nlm.nih.gov/17034116 DMJ38YV DI DMJ38YV DMJ38YV DN QEDIIRNIARHLAQVGDSMDR DMJ38YV MI TTRE6AX DMJ38YV MN Bcl-x messenger RNA (BCL2L1 mRNA) DMJ38YV MT DTT DMJ38YV MA Inhibitor DMJ38YV RN Structure-based design of potent small-molecule inhibitors of anti-apoptotic Bcl-2 proteins. J Med Chem. 2006 Oct 19;49(21):6139-42. DMJ38YV RU https://pubmed.ncbi.nlm.nih.gov/17034116 DMJ38YV DI DMJ38YV DMJ38YV DN QEDIIRNIARHLAQVGDSMDR DMJ38YV MI TTL53M6 DMJ38YV MN Induced myeloid leukemia cell differentiation protein Mcl-1 (MCL1) DMJ38YV MT DTT DMJ38YV MA Inhibitor DMJ38YV RN Structure-based design of potent small-molecule inhibitors of anti-apoptotic Bcl-2 proteins. J Med Chem. 2006 Oct 19;49(21):6139-42. DMJ38YV RU https://pubmed.ncbi.nlm.nih.gov/17034116 DMWOSFJ DI DMWOSFJ DMWOSFJ DN QLT-091382 DMWOSFJ MI TTY84UG DMWOSFJ MN Acetyl-CoA carboxylase 2 (ACACB) DMWOSFJ MT DTT DMWOSFJ MA Inhibitor DMWOSFJ RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1264). DMWOSFJ RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1264 DMTY5HP DI DMTY5HP DMTY5HP DN QNEQCPQVSac DMTY5HP MI TT2UE56 DMTY5HP MN Sodium/glucose cotransporter 1 (SGLT1) DMTY5HP MT DTT DMTY5HP MA Inhibitor DMTY5HP RN Tripeptides of RS1 (RSC1A1) inhibit a monosaccharide-dependent exocytotic pathway of Na+-D-glucose cotransporter SGLT1 with high affinity. J Biol Chem. 2007 Sep 28;282(39):28501-13. DMTY5HP RU https://pubmed.ncbi.nlm.nih.gov/17686765 DM01RZX DI DM01RZX DM01RZX DN QNZ 46 DM01RZX MI TT5POTG DM01RZX MN Glutamate receptor ionotropic NMDA 2D (GluN2D) DM01RZX MT DTT DM01RZX MA Modulator (allosteric modulator) DM01RZX RN Structural and mechanistic determinants of a novel site for noncompetitive inhibition of GluN2D-containing NMDA receptors. J Neurosci. 2011 Mar 9;31(10):3650-61. DM01RZX RU https://pubmed.ncbi.nlm.nih.gov/21389220 DMYXPF8 DI DMYXPF8 DMYXPF8 DN QO-58 DMYXPF8 MI TTPXI3S DMYXPF8 MN Voltage-gated potassium channel Kv7.2 (KCNQ2) DMYXPF8 MT DTT DMYXPF8 MA Activator DMYXPF8 RN Modulation of K(v)7 potassium channels by a novel opener pyrazolo[1,5-a]pyrimidin-7(4H)-one compound QO-58. Br J Pharmacol. 2013 Feb;168(4):1030-42. DMYXPF8 RU https://pubmed.ncbi.nlm.nih.gov/23013484 DMJHTUG DI DMJHTUG DMJHTUG DN QSPac DMJHTUG MI TT2UE56 DMJHTUG MN Sodium/glucose cotransporter 1 (SGLT1) DMJHTUG MT DTT DMJHTUG MA Inhibitor DMJHTUG RN Tripeptides of RS1 (RSC1A1) inhibit a monosaccharide-dependent exocytotic pathway of Na+-D-glucose cotransporter SGLT1 with high affinity. J Biol Chem. 2007 Sep 28;282(39):28501-13. DMJHTUG RU https://pubmed.ncbi.nlm.nih.gov/17686765 DM2Q6JY DI DM2Q6JY DM2Q6JY DN quadazocine DM2Q6JY MI TT27RFC DM2Q6JY MN Opioid receptor delta (OPRD1) DM2Q6JY MT DTT DM2Q6JY MA Antagonist DM2Q6JY RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 317). DM2Q6JY RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=317 DM2Q6JY DI DM2Q6JY DM2Q6JY DN quadazocine DM2Q6JY MI TTQW87Y DM2Q6JY MN Opioid receptor kappa (OPRK1) DM2Q6JY MT DTT DM2Q6JY MA Antagonist DM2Q6JY RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 318). DM2Q6JY RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=318 DM2Q6JY DI DM2Q6JY DM2Q6JY DN quadazocine DM2Q6JY MI TTKWM86 DM2Q6JY MN Opioid receptor mu (MOP) DM2Q6JY MT DTT DM2Q6JY MA Antagonist DM2Q6JY RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 319). DM2Q6JY RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=319 DMXIU6W DI DMXIU6W DMXIU6W DN Quercetin 3-O-neohesperidoside DMXIU6W MI TTFBNVI DMXIU6W MN Aldose reductase (AKR1B1) DMXIU6W MT DTT DMXIU6W MA Inhibitor DMXIU6W RN New flavonol oligoglycosides and polyacylated sucroses with inhibitory effects on aldose reductase and platelet aggregation from the flowers of Pru... J Nat Prod. 2002 Aug;65(8):1151-5. DMXIU6W RU https://pubmed.ncbi.nlm.nih.gov/12193020 DM1DH96 DI DM1DH96 DM1DH96 DN QUERCITRIN DM1DH96 MI TTFBNVI DM1DH96 MN Aldose reductase (AKR1B1) DM1DH96 MT DTT DM1DH96 MA Inhibitor DM1DH96 RN Erigeroflavanone, a flavanone derivative from the flowers of Erigeron annuus with protein glycation and aldose reductase inhibitory activity. J Nat Prod. 2008 Apr;71(4):713-5. DM1DH96 RU https://pubmed.ncbi.nlm.nih.gov/18298080 DM9YWG8 DI DM9YWG8 DM9YWG8 DN Quick-acting insulin DM9YWG8 MI TTCBFJO DM9YWG8 MN Insulin receptor (INSR) DM9YWG8 MT DTT DM9YWG8 MA Modulator DM9YWG8 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1800). DM9YWG8 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1800 DM0BEZS DI DM0BEZS DM0BEZS DN Quinapril analogue DM0BEZS MI TTGY8IW DM0BEZS MN B2 bradykinin receptor (BDKRB2) DM0BEZS MT DTT DM0BEZS MA Inhibitor DM0BEZS RN Ace inhibitors as a template for the design of bradykinin B2 receptor antagonists, Bioorg. Med. Chem. Lett. 5(4):367-370 (1995). DM0BEZS RU http://www.sciencedirect.com/science/article/pii/0960894X9500037T DMJDU5S DI DMJDU5S DMJDU5S DN quinazoline deriv. 1 DMJDU5S MI TT9RTBL DMJDU5S MN Aurora B messenger RNA (AURKB mRNA) DMJDU5S MT DTT DMJDU5S MA Inhibitor DMJDU5S RN A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases. Proc Natl Acad Sci U S A. 2007 Dec 18;104(51):20523-8. DMJDU5S RU https://pubmed.ncbi.nlm.nih.gov/18077363 DMJDU5S DI DMJDU5S DMJDU5S DN quinazoline deriv. 1 DMJDU5S MI TTLYXIT DMJDU5S MN Aurora kinase C (AURKC) DMJDU5S MT DTT DMJDU5S MA Inhibitor DMJDU5S RN A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases. Proc Natl Acad Sci U S A. 2007 Dec 18;104(51):20523-8. DMJDU5S RU https://pubmed.ncbi.nlm.nih.gov/18077363 DMVQYWS DI DMVQYWS DMVQYWS DN quin-C1 DMVQYWS MI TTOJ1NF DMVQYWS MN FMLP-related receptor I (FPR2) DMVQYWS MT DTT DMVQYWS MA Agonist DMVQYWS RN A novel nonpeptide ligand for formyl peptide receptor-like 1. Mol Pharmacol. 2004 Nov;66(5):1213-22. DMVQYWS RU https://pubmed.ncbi.nlm.nih.gov/15308762 DM1CYWB DI DM1CYWB DM1CYWB DN quin-C7 DM1CYWB MI TTOJ1NF DM1CYWB MN FMLP-related receptor I (FPR2) DM1CYWB MT DTT DM1CYWB MA Antagonist DM1CYWB RN Pharmacological characterization of a novel nonpeptide antagonist for formyl peptide receptor-like 1. Mol Pharmacol. 2007 Oct;72(4):976-83. DM1CYWB RU https://pubmed.ncbi.nlm.nih.gov/17652444 DMRQCK3 DI DMRQCK3 DMRQCK3 DN Quinizarin DMRQCK3 MI TTGTQHC DMRQCK3 MN DNA topoisomerase I (TOP1) DMRQCK3 MT DTT DMRQCK3 MA Binder DMRQCK3 RN Comparison of responses of DNA topoisomerase I from Candida albicans and human cells to four new agents which stimulate topoisomerase-dependent DNA nicking. FEMS Microbiol Lett. 1996 May 1;138(2-3):105-11. DMRQCK3 RU https://pubmed.ncbi.nlm.nih.gov/9026436 DM1QIPZ DI DM1QIPZ DM1QIPZ DN quinoline 2 DM1QIPZ MI TT2EDHU DM1QIPZ MN Insulin-degrading enzyme (IDE) DM1QIPZ MT DTT DM1QIPZ MA Inhibitor DM1QIPZ RN Dual Exosite-binding Inhibitors of Insulin-degrading Enzyme Challenge Its Role as the Primary Mediator of Insulin Clearance in Vivo. J Biol Chem. 2015 Aug 14;290(33):20044-59. DM1QIPZ RU https://pubmed.ncbi.nlm.nih.gov/26085101 DMDY3I2 DI DMDY3I2 DMDY3I2 DN Quinoline-2-carboxylic acid adamantan-1-ylamide DMDY3I2 MI TTVBPDM DMDY3I2 MN Metabotropic glutamate receptor 1 (mGluR1) DMDY3I2 MT DTT DMDY3I2 MA Inhibitor DMDY3I2 RN Positive and negative modulation of group I metabotropic glutamate receptors. J Med Chem. 2008 Feb 14;51(3):634-47. DMDY3I2 RU https://pubmed.ncbi.nlm.nih.gov/18173231 DM9BIVL DI DM9BIVL DM9BIVL DN Quinoline-3-carboxylic acid adamantan-1-ylamide DM9BIVL MI TTVBPDM DM9BIVL MN Metabotropic glutamate receptor 1 (mGluR1) DM9BIVL MT DTT DM9BIVL MA Inhibitor DM9BIVL RN Positive and negative modulation of group I metabotropic glutamate receptors. J Med Chem. 2008 Feb 14;51(3):634-47. DM9BIVL RU https://pubmed.ncbi.nlm.nih.gov/18173231 DMV57OZ DI DMV57OZ DMV57OZ DN Quinoline-8-carboxamide DMV57OZ MI TTVDSZ0 DMV57OZ MN Poly [ADP-ribose] polymerase 1 (PARP1) DMV57OZ MT DTT DMV57OZ MA Inhibitor DMV57OZ RN Design, synthesis, and evaluation in vitro of quinoline-8-carboxamides, a new class of poly(adenosine-diphosphate-ribose)polymerase-1 (PARP-1) inhi... J Med Chem. 2009 Feb 12;52(3):868-77. DMV57OZ RU https://pubmed.ncbi.nlm.nih.gov/19117416 DMTPFLU DI DMTPFLU DMTPFLU DN Quinoline-8-sulfonamide DMTPFLU MI TTANPDJ DMTPFLU MN Carbonic anhydrase II (CA-II) DMTPFLU MT DTT DMTPFLU MA Inhibitor DMTPFLU RN Ligand-based and structure-based virtual screening to identify carbonic anhydrase IX inhibitors. Bioorg Med Chem. 2009 Jan 15;17(2):553-7. DMTPFLU RU https://pubmed.ncbi.nlm.nih.gov/19097911 DMTPFLU DI DMTPFLU DMTPFLU DN Quinoline-8-sulfonamide DMTPFLU MI TT2LVK8 DMTPFLU MN Carbonic anhydrase IX (CA-IX) DMTPFLU MT DTT DMTPFLU MA Inhibitor DMTPFLU RN Ligand-based and structure-based virtual screening to identify carbonic anhydrase IX inhibitors. Bioorg Med Chem. 2009 Jan 15;17(2):553-7. DMTPFLU RU https://pubmed.ncbi.nlm.nih.gov/19097911 DM8YGOI DI DM8YGOI DM8YGOI DN Quinolinic Acid DM8YGOI MI TTH29K0 DM8YGOI MN Mycobacterium Nicotinate-nucleotide pyrophosphorylase (MycB nadC) DM8YGOI MT DTT DM8YGOI MA Inhibitor DM8YGOI RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DM8YGOI RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMRWXH4 DI DMRWXH4 DMRWXH4 DN Quinoxaline1 DMRWXH4 MI TTH6V3D DMRWXH4 MN Cyclin-dependent kinase 1 (CDK1) DMRWXH4 MT DTT DMRWXH4 MA Inhibitor DMRWXH4 RN A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases. Proc Natl Acad Sci U S A. 2007 Dec 18;104(51):20523-8. DMRWXH4 RU https://pubmed.ncbi.nlm.nih.gov/18077363 DMRWXH4 DI DMRWXH4 DMRWXH4 DN Quinoxaline1 DMRWXH4 MI TTL4Q97 DMRWXH4 MN Cyclin-dependent kinase 5 (CDK5) DMRWXH4 MT DTT DMRWXH4 MA Inhibitor DMRWXH4 RN A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases. Proc Natl Acad Sci U S A. 2007 Dec 18;104(51):20523-8. DMRWXH4 RU https://pubmed.ncbi.nlm.nih.gov/18077363 DMRWXH4 DI DMRWXH4 DMRWXH4 DN Quinoxaline1 DMRWXH4 MI TTRSMW9 DMRWXH4 MN Glycogen synthase kinase-3 beta (GSK-3B) DMRWXH4 MT DTT DMRWXH4 MA Inhibitor DMRWXH4 RN A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases. Proc Natl Acad Sci U S A. 2007 Dec 18;104(51):20523-8. DMRWXH4 RU https://pubmed.ncbi.nlm.nih.gov/18077363 DMDNHEP DI DMDNHEP DMDNHEP DN QUINPIROLE DMDNHEP MI TTZFYLI DMDNHEP MN Dopamine D1 receptor (D1R) DMDNHEP MT DTT DMDNHEP MA Inhibitor DMDNHEP RN Pharmacophore-guided drug discovery investigations leading to bioactive 5-aminotetrahydropyrazolopyridines. Implications for the binding mode of he... J Med Chem. 2005 Sep 8;48(18):5771-9. DMDNHEP RU https://pubmed.ncbi.nlm.nih.gov/16134944 DMDNHEP DI DMDNHEP DMDNHEP DN QUINPIROLE DMDNHEP MI TTEX248 DMDNHEP MN Dopamine D2 receptor (D2R) DMDNHEP MT DTT DMDNHEP MA Inhibitor DMDNHEP RN N-n-Propyl-substituted 3-(dimethylphenyl)piperidines display novel discriminative properties between dopamine receptor subtypes: synthesis and rece... J Med Chem. 1998 Dec 3;41(25):4933-8. DMDNHEP RU https://pubmed.ncbi.nlm.nih.gov/9836610 DMDNHEP DI DMDNHEP DMDNHEP DN QUINPIROLE DMDNHEP MI TT4C8EA DMDNHEP MN Dopamine D3 receptor (D3R) DMDNHEP MT DTT DMDNHEP MA Inhibitor DMDNHEP RN 1,1'-Disubstituted ferrocenes as molecular hinges in mono- and bivalent dopamine receptor ligands. J Med Chem. 2009 Nov 12;52(21):6860-70. DMDNHEP RU https://pubmed.ncbi.nlm.nih.gov/19807103 DMDNHEP DI DMDNHEP DMDNHEP DN QUINPIROLE DMDNHEP MI TTE0A2F DMDNHEP MN Dopamine D4 receptor (D4R) DMDNHEP MT DTT DMDNHEP MA Inhibitor DMDNHEP RN Pharmacophore-guided drug discovery investigations leading to bioactive 5-aminotetrahydropyrazolopyridines. Implications for the binding mode of he... J Med Chem. 2005 Sep 8;48(18):5771-9. DMDNHEP RU https://pubmed.ncbi.nlm.nih.gov/16134944 DMPY6IG DI DMPY6IG DMPY6IG DN Quipazine DMPY6IG MI TTSQIFT DMPY6IG MN 5-HT 1A receptor (HTR1A) DMPY6IG MT DTT DMPY6IG MA Inhibitor DMPY6IG RN Novel, potent, and selective quinoxaline-based 5-HT(3) receptor ligands. 1. Further structure-activity relationships and pharmacological characteri... J Med Chem. 2009 Nov 12;52(21):6946-50. DMPY6IG RU https://pubmed.ncbi.nlm.nih.gov/19831400 DMPY6IG DI DMPY6IG DMPY6IG DN Quipazine DMPY6IG MI TT6MSOK DMPY6IG MN 5-HT 1D receptor (HTR1D) DMPY6IG MT DTT DMPY6IG MA Inhibitor DMPY6IG RN 5-HT1 and 5-HT2 binding characteristics of some quipazine analogues. J Med Chem. 1986 Nov;29(11):2375-80. DMPY6IG RU https://pubmed.ncbi.nlm.nih.gov/3783595 DMPY6IG DI DMPY6IG DMPY6IG DN Quipazine DMPY6IG MI TTJQOD7 DMPY6IG MN 5-HT 2A receptor (HTR2A) DMPY6IG MT DTT DMPY6IG MA Inhibitor DMPY6IG RN Novel, potent, and selective quinoxaline-based 5-HT(3) receptor ligands. 1. Further structure-activity relationships and pharmacological characteri... J Med Chem. 2009 Nov 12;52(21):6946-50. DMPY6IG RU https://pubmed.ncbi.nlm.nih.gov/19831400 DMPY6IG DI DMPY6IG DMPY6IG DN Quipazine DMPY6IG MI TTPC4TU DMPY6IG MN 5-HT 3A receptor (HTR3A) DMPY6IG MT DTT DMPY6IG MA Inhibitor DMPY6IG RN Novel, potent, and selective quinoxaline-based 5-HT(3) receptor ligands. 1. Further structure-activity relationships and pharmacological characteri... J Med Chem. 2009 Nov 12;52(21):6946-50. DMPY6IG RU https://pubmed.ncbi.nlm.nih.gov/19831400 DMPY6IG DI DMPY6IG DMPY6IG DN Quipazine DMPY6IG MI TTR6K75 DMPY6IG MN 5-HT 3B receptor (HTR3B) DMPY6IG MT DTT DMPY6IG MA Inhibitor DMPY6IG RN Novel potent and selective central 5-HT3 receptor ligands provided with different intrinsic efficacy. 2. Molecular basis of the intrinsic efficacy ... J Med Chem. 1999 May 6;42(9):1556-75. DMPY6IG RU https://pubmed.ncbi.nlm.nih.gov/10229626 DMPY6IG DI DMPY6IG DMPY6IG DN Quipazine DMPY6IG MI TTJS8PY DMPY6IG MN 5-HT 6 receptor (HTR6) DMPY6IG MT DTT DMPY6IG MA Inhibitor DMPY6IG RN Higher-end serotonin receptors: 5-HT(5), 5-HT(6), and 5-HT(7). J Med Chem. 2003 Jul 3;46(14):2795-812. DMPY6IG RU https://pubmed.ncbi.nlm.nih.gov/12825922 DMPY6IG DI DMPY6IG DMPY6IG DN Quipazine DMPY6IG MI TT3ROYC DMPY6IG MN Serotonin transporter (SERT) DMPY6IG MT DTT DMPY6IG MA Inhibitor DMPY6IG RN Syntheses and binding affinities of 6-nitroquipazine analogues for serotonin transporter. Part 1. Bioorg Med Chem Lett. 2000 Jul 17;10(14):1559-62. DMPY6IG RU https://pubmed.ncbi.nlm.nih.gov/10915050 DM9KMEI DI DM9KMEI DM9KMEI DN Quizalofop DM9KMEI MI TTYAWV0 DM9KMEI MN Plasmodium Acetyl-CoA carboxylase 1 (Malaria ACC1) DM9KMEI MT DTT DM9KMEI MA Binder DM9KMEI RN The apicoplast as an antimalarial drug target. Drug Resist Updat. 2001 Jun;4(3):145-51. DM9KMEI RU https://pubmed.ncbi.nlm.nih.gov/11768328 DMQ7PIL DI DMQ7PIL DMQ7PIL DN QwFwLL-NH2 DMQ7PIL MI TTWDC17 DMQ7PIL MN Growth hormone secretagogue receptor 1 (GHSR) DMQ7PIL MT DTT DMQ7PIL MA Inhibitor DMQ7PIL RN Identification of an efficacy switch region in the ghrelin receptor responsible for interchange between agonism and inverse agonism. J Biol Chem. 2007 May 25;282(21):15799-811. DMQ7PIL RU https://pubmed.ncbi.nlm.nih.gov/17371869 DM72ES1 DI DM72ES1 DM72ES1 DN R(-)amphetamine DM72ES1 MI TTIU98M DM72ES1 MN Trace amine-associated receptor-1 (TAAR1) DM72ES1 MT DTT DM72ES1 MA Agonist DM72ES1 RN The Trace Amine 1 receptor knockout mouse: an animal model with relevance to schizophrenia. Genes Brain Behav. 2007 Oct;6(7):628-39. DM72ES1 RU https://pubmed.ncbi.nlm.nih.gov/17212650 DM4URMA DI DM4URMA DM4URMA DN R,R-THC DM4URMA MI TTZAYWL DM4URMA MN Estrogen receptor (ESR) DM4URMA MT DTT DM4URMA MA Agonist DM4URMA RN Novel ligands that function as selective estrogens or antiestrogens for estrogen receptor-alpha or estrogen receptor-beta. Endocrinology. 1999 Feb;140(2):800-4. DM4URMA RU https://pubmed.ncbi.nlm.nih.gov/9927308 DM4URMA DI DM4URMA DM4URMA DN R,R-THC DM4URMA MI TTOM3J0 DM4URMA MN Estrogen receptor beta (ESR2) DM4URMA MT DTT DM4URMA MA Antagonist DM4URMA RN Estrogen receptor subtype-selective ligands: asymmetric synthesis and biological evaluation of cis- and trans-5,11-dialkyl- 5,6,11, 12-tetrahydrochrysenes. J Med Chem. 1999 Jul 1;42(13):2456-68. DM4URMA RU https://pubmed.ncbi.nlm.nih.gov/10395487 DMK0YP7 DI DMK0YP7 DMK0YP7 DN R-1 DMK0YP7 MI TT0K1SC DMK0YP7 MN 5-HT 2B receptor (HTR2B) DMK0YP7 MT DTT DMK0YP7 MA Antagonist DMK0YP7 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 7). DMK0YP7 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=7 DM6Y7QM DI DM6Y7QM DM6Y7QM DN R116031 DM6Y7QM MI TTZPO1L DM6Y7QM MN Substance-P receptor (TACR1) DM6Y7QM MT DTT DM6Y7QM MA Antagonist DM6Y7QM RN Pharmacological profile of (2R-trans)-4-[1-[3,5-bis(trifluoromethyl)benzoyl]-2-(phenylmethyl)-4-piperidinyl]-N-(2,6-dimethylphenyl)-1-acetamide (S)-Hydroxybutanedioate (R116301), an orally and centrally active neurokinin-1 receptor antagonist. J Pharmacol Exp Ther. 2002 Aug;302(2):696-709. DM6Y7QM RU https://pubmed.ncbi.nlm.nih.gov/12130734 DMJ14OV DI DMJ14OV DMJ14OV DN R-116712 DMJ14OV MI TT07C3Y DMJ14OV MN 5-HT 4 receptor (HTR4) DMJ14OV MT DTT DMJ14OV MA Antagonist DMJ14OV RN Mapping of serotonin 5-HT(4) receptor mRNA and ligand binding sites in the post-mortem human brain. Synapse. 2000 Apr;36(1):35-46. DMJ14OV RU https://pubmed.ncbi.nlm.nih.gov/10700024 DML49FI DI DML49FI DML49FI DN R-138727 DML49FI MI TTZ1DT0 DML49FI MN P2Y purinoceptor 12 (P2RY12) DML49FI MT DTT DML49FI MA Antagonist DML49FI RN Stereoselective inhibition of human platelet aggregation by R-138727, the active metabolite of CS-747 (prasugrel, LY640315), a novel P2Y12 receptor inhibitor. Thromb Haemost. 2005 Sep;94(3):593-8. DML49FI RU https://pubmed.ncbi.nlm.nih.gov/16268477 DMX80BL DI DMX80BL DMX80BL DN R214127 DMX80BL MI TTVBPDM DMX80BL MN Metabotropic glutamate receptor 1 (mGluR1) DMX80BL MT DTT DMX80BL MA Modulator (allosteric modulator) DMX80BL RN [3H]R214127: a novel high-affinity radioligand for the mGlu1 receptor reveals a common binding site shared by multiple allosteric antagonists. Mol Pharmacol. 2003 May;63(5):1082-93. DMX80BL RU https://pubmed.ncbi.nlm.nih.gov/12695537 DM4BP7S DI DM4BP7S DM4BP7S DN R-226161 DM4BP7S MI TTNGILX DM4BP7S MN Adrenergic receptor alpha-1A (ADRA1A) DM4BP7S MT DTT DM4BP7S MA Inhibitor DM4BP7S RN Tricyclic isoxazolines: identification of R226161 as a potential new antidepressant that combines potent serotonin reuptake inhibition and alpha2-a... Bioorg Med Chem. 2007 Jun 1;15(11):3649-60. DM4BP7S RU https://pubmed.ncbi.nlm.nih.gov/17407815 DM4BP7S DI DM4BP7S DM4BP7S DN R-226161 DM4BP7S MI TTWG9A4 DM4BP7S MN Adrenergic receptor alpha-2A (ADRA2A) DM4BP7S MT DTT DM4BP7S MA Inhibitor DM4BP7S RN Tricyclic isoxazolines: identification of R226161 as a potential new antidepressant that combines potent serotonin reuptake inhibition and alpha2-a... Bioorg Med Chem. 2007 Jun 1;15(11):3649-60. DM4BP7S RU https://pubmed.ncbi.nlm.nih.gov/17407815 DM4BP7S DI DM4BP7S DM4BP7S DN R-226161 DM4BP7S MI TTWM4TY DM4BP7S MN Adrenergic receptor alpha-2B (ADRA2B) DM4BP7S MT DTT DM4BP7S MA Inhibitor DM4BP7S RN Tricyclic isoxazolines: identification of R226161 as a potential new antidepressant that combines potent serotonin reuptake inhibition and alpha2-a... Bioorg Med Chem. 2007 Jun 1;15(11):3649-60. DM4BP7S RU https://pubmed.ncbi.nlm.nih.gov/17407815 DM4BP7S DI DM4BP7S DM4BP7S DN R-226161 DM4BP7S MI TT2NUT5 DM4BP7S MN Adrenergic receptor alpha-2C (ADRA2C) DM4BP7S MT DTT DM4BP7S MA Inhibitor DM4BP7S RN Tricyclic isoxazolines: identification of R226161 as a potential new antidepressant that combines potent serotonin reuptake inhibition and alpha2-a... Bioorg Med Chem. 2007 Jun 1;15(11):3649-60. DM4BP7S RU https://pubmed.ncbi.nlm.nih.gov/17407815 DM4BP7S DI DM4BP7S DM4BP7S DN R-226161 DM4BP7S MI TT4C8EA DM4BP7S MN Dopamine D3 receptor (D3R) DM4BP7S MT DTT DM4BP7S MA Inhibitor DM4BP7S RN Tricyclic isoxazolines: identification of R226161 as a potential new antidepressant that combines potent serotonin reuptake inhibition and alpha2-a... Bioorg Med Chem. 2007 Jun 1;15(11):3649-60. DM4BP7S RU https://pubmed.ncbi.nlm.nih.gov/17407815 DM4BP7S DI DM4BP7S DM4BP7S DN R-226161 DM4BP7S MI TTVBI8W DM4BP7S MN Dopamine transporter (DAT) DM4BP7S MT DTT DM4BP7S MA Inhibitor DM4BP7S RN Tricyclic isoxazolines: identification of R226161 as a potential new antidepressant that combines potent serotonin reuptake inhibition and alpha2-a... Bioorg Med Chem. 2007 Jun 1;15(11):3649-60. DM4BP7S RU https://pubmed.ncbi.nlm.nih.gov/17407815 DM4BP7S DI DM4BP7S DM4BP7S DN R-226161 DM4BP7S MI TTTIBOJ DM4BP7S MN Histamine H1 receptor (H1R) DM4BP7S MT DTT DM4BP7S MA Inhibitor DM4BP7S RN Tricyclic isoxazolines: identification of R226161 as a potential new antidepressant that combines potent serotonin reuptake inhibition and alpha2-a... Bioorg Med Chem. 2007 Jun 1;15(11):3649-60. DM4BP7S RU https://pubmed.ncbi.nlm.nih.gov/17407815 DM4BP7S DI DM4BP7S DM4BP7S DN R-226161 DM4BP7S MI TT3ROYC DM4BP7S MN Serotonin transporter (SERT) DM4BP7S MT DTT DM4BP7S MA Inhibitor DM4BP7S RN Tricyclic isoxazolines: identification of R226161 as a potential new antidepressant that combines potent serotonin reuptake inhibition and alpha2-a... Bioorg Med Chem. 2007 Jun 1;15(11):3649-60. DM4BP7S RU https://pubmed.ncbi.nlm.nih.gov/17407815 DM4BP7S DI DM4BP7S DM4BP7S DN R-226161 DM4BP7S MI TTZPO1L DM4BP7S MN Substance-P receptor (TACR1) DM4BP7S MT DTT DM4BP7S MA Inhibitor DM4BP7S RN Tricyclic isoxazolines: identification of R226161 as a potential new antidepressant that combines potent serotonin reuptake inhibition and alpha2-a... Bioorg Med Chem. 2007 Jun 1;15(11):3649-60. DM4BP7S RU https://pubmed.ncbi.nlm.nih.gov/17407815 DM1OPZ9 DI DM1OPZ9 DM1OPZ9 DN R396 DM1OPZ9 MI TTYO0A3 DM1OPZ9 MN Substance-K receptor (TACR2) DM1OPZ9 MT DTT DM1OPZ9 MA Antagonist DM1OPZ9 RN Characterization of the binding sites of [3H]SR 48968, a potent nonpeptide radioligand antagonist of the neurokinin-2 receptor. Biochem Biophys Res Commun. 1993 Mar 31;191(3):1172-7. DM1OPZ9 RU https://pubmed.ncbi.nlm.nih.gov/7682062 DMSHMIK DI DMSHMIK DMSHMIK DN R-65 DMSHMIK MI TT1ZAVI DMSHMIK MN Prostaglandin E2 receptor EP2 (PTGER2) DMSHMIK MT DTT DMSHMIK MA Modulator DMSHMIK RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 341). DMSHMIK RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=341 DMHX9CT DI DMHX9CT DMHX9CT DN R-820 DMHX9CT MI TTBPGLU DMHX9CT MN Neuromedin-K receptor (TACR3) DMHX9CT MT DTT DMHX9CT MA Antagonist DMHX9CT RN Implication of nigral tachykinin NK3 receptors in the maintenance of hypertension in spontaneously hypertensive rats: a pharmacologic and autoradiographic study. Br J Pharmacol. 2003 Feb;138(4):554-63. DMHX9CT RU https://pubmed.ncbi.nlm.nih.gov/12598409 DM1MIRJ DI DM1MIRJ DM1MIRJ DN R-84 DM1MIRJ MI TTUTJGQ DM1MIRJ MN Vascular endothelial growth factor receptor 2 (KDR) DM1MIRJ MT DTT DM1MIRJ RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1813). DM1MIRJ RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1813 DM2QN0S DI DM2QN0S DM2QN0S DN R-87027 DM2QN0S MI TT84ETX DM2QN0S MN Human immunodeficiency virus Reverse transcriptase (HIV RT) DM2QN0S MT DTT DM2QN0S MA Inhibitor DM2QN0S RN Prediction of binding affinities for TIBO inhibitors of HIV-1 reverse transcriptase using Monte Carlo simulations in a linear response method. J Med Chem. 1998 Dec 17;41(26):5272-86. DM2QN0S RU https://pubmed.ncbi.nlm.nih.gov/9857095 DMTUR6C DI DMTUR6C DMTUR6C DN Rac-2-amino-4-phenylbutanoic acid DMTUR6C MI TTFK1JQ DMTUR6C MN Voltage-gated calcium channel alpha-2/delta-1 (CACNA2D1) DMTUR6C MT DTT DMTUR6C MA Inhibitor DMTUR6C RN Structure-activity relationships of alpha-amino acid ligands for the alpha2delta subunit of voltage-gated calcium channels. Bioorg Med Chem Lett. 2006 Mar 1;16(5):1138-41. DMTUR6C RU https://pubmed.ncbi.nlm.nih.gov/16380257 DMU0746 DI DMU0746 DMU0746 DN Rac-2-amino-5-cyclohexylpentanoic acid DMU0746 MI TTFK1JQ DMU0746 MN Voltage-gated calcium channel alpha-2/delta-1 (CACNA2D1) DMU0746 MT DTT DMU0746 MA Inhibitor DMU0746 RN Structure-activity relationships of alpha-amino acid ligands for the alpha2delta subunit of voltage-gated calcium channels. Bioorg Med Chem Lett. 2006 Mar 1;16(5):1138-41. DMU0746 RU https://pubmed.ncbi.nlm.nih.gov/16380257 DMD5TPH DI DMD5TPH DMD5TPH DN Rac-2q DMD5TPH MI TT8VUE0 DMD5TPH MN Chymase (CYM) DMD5TPH MT DTT DMD5TPH MA Inhibitor DMD5TPH RN Identification of 6-substituted 4-arylsulfonyl-1,4-diazepane-2,5-diones as a novel scaffold for human chymase inhibitors. Bioorg Med Chem Lett. 2007 Jun 15;17(12):3431-4. DMD5TPH RU https://pubmed.ncbi.nlm.nih.gov/17419055 DMTN7IU DI DMTN7IU DMTN7IU DN Rac-4'-(1-Imidazol-1-yl-propyl)-biphenyl-3,4-diol DMTN7IU MI TTRA5BZ DMTN7IU MN Steroid 17-alpha-monooxygenase (S17AH) DMTN7IU MT DTT DMTN7IU MA Inhibitor DMTN7IU RN Novel CYP17 inhibitors: synthesis, biological evaluation, structure-activity relationships and modelling of methoxy- and hydroxy-substituted methyl... Eur J Med Chem. 2009 Jul;44(7):2765-75. DMTN7IU RU https://pubmed.ncbi.nlm.nih.gov/19211174 DMQYRAB DI DMQYRAB DMQYRAB DN Rac-4'-(1-Imidazol-1-yl-propyl)-biphenyl-3,5-diol DMQYRAB MI TTRA5BZ DMQYRAB MN Steroid 17-alpha-monooxygenase (S17AH) DMQYRAB MT DTT DMQYRAB MA Inhibitor DMQYRAB RN Novel CYP17 inhibitors: synthesis, biological evaluation, structure-activity relationships and modelling of methoxy- and hydroxy-substituted methyl... Eur J Med Chem. 2009 Jul;44(7):2765-75. DMQYRAB RU https://pubmed.ncbi.nlm.nih.gov/19211174 DMH2CX5 DI DMH2CX5 DMH2CX5 DN Rac-4'-(1-Imidazol-1-yl-propyl)-biphenyl-3-ol DMH2CX5 MI TTRA5BZ DMH2CX5 MN Steroid 17-alpha-monooxygenase (S17AH) DMH2CX5 MT DTT DMH2CX5 MA Inhibitor DMH2CX5 RN Novel CYP17 inhibitors: synthesis, biological evaluation, structure-activity relationships and modelling of methoxy- and hydroxy-substituted methyl... Eur J Med Chem. 2009 Jul;44(7):2765-75. DMH2CX5 RU https://pubmed.ncbi.nlm.nih.gov/19211174 DMUQ6FW DI DMUQ6FW DMUQ6FW DN Rac-4'-(1-Imidazol-1-yl-propyl)-biphenyl-4-ol DMUQ6FW MI TTRA5BZ DMUQ6FW MN Steroid 17-alpha-monooxygenase (S17AH) DMUQ6FW MT DTT DMUQ6FW MA Inhibitor DMUQ6FW RN Novel CYP17 inhibitors: synthesis, biological evaluation, structure-activity relationships and modelling of methoxy- and hydroxy-substituted methyl... Eur J Med Chem. 2009 Jul;44(7):2765-75. DMUQ6FW RU https://pubmed.ncbi.nlm.nih.gov/19211174 DMR8L6O DI DMR8L6O DMR8L6O DN Rac-cis-N-arachidonoylcyclopropanolamide DMR8L6O MI TT6OEDT DMR8L6O MN Cannabinoid receptor 1 (CB1) DMR8L6O MT DTT DMR8L6O MA Inhibitor DMR8L6O RN Conformationally constrained fatty acid ethanolamides as cannabinoid and vanilloid receptor probes. J Med Chem. 2009 May 14;52(9):3001-9. DMR8L6O RU https://pubmed.ncbi.nlm.nih.gov/19361197 DMR8L6O DI DMR8L6O DMR8L6O DN Rac-cis-N-arachidonoylcyclopropanolamide DMR8L6O MI TTMSFAW DMR8L6O MN Cannabinoid receptor 2 (CB2) DMR8L6O MT DTT DMR8L6O MA Inhibitor DMR8L6O RN Conformationally constrained fatty acid ethanolamides as cannabinoid and vanilloid receptor probes. J Med Chem. 2009 May 14;52(9):3001-9. DMR8L6O RU https://pubmed.ncbi.nlm.nih.gov/19361197 DM39FSQ DI DM39FSQ DM39FSQ DN Racemic DOI DM39FSQ MI TTJQOD7 DM39FSQ MN 5-HT 2A receptor (HTR2A) DM39FSQ MT DTT DM39FSQ MA Inhibitor DM39FSQ RN The role of lipophilicity in determining binding affinity and functional activity for 5-HT2A receptor ligands. Bioorg Med Chem. 2008 Apr 15;16(8):4661-9. DM39FSQ RU https://pubmed.ncbi.nlm.nih.gov/18296055 DM39FSQ DI DM39FSQ DM39FSQ DN Racemic DOI DM39FSQ MI TT0K1SC DM39FSQ MN 5-HT 2B receptor (HTR2B) DM39FSQ MT DTT DM39FSQ MA Inhibitor DM39FSQ RN cis-4-(Piperazin-1-yl)-5,6,7a,8,9,10,11,11a-octahydrobenzofuro[2,3-h]quinazolin-2-amine (A-987306), a new histamine H4R antagonist that blocks pain... J Med Chem. 2008 Nov 27;51(22):7094-8. DM39FSQ RU https://pubmed.ncbi.nlm.nih.gov/18983139 DMNLCUH DI DMNLCUH DMNLCUH DN Racemic DOTFM DMNLCUH MI TTJQOD7 DMNLCUH MN 5-HT 2A receptor (HTR2A) DMNLCUH MT DTT DMNLCUH MA Inhibitor DMNLCUH RN The role of lipophilicity in determining binding affinity and functional activity for 5-HT2A receptor ligands. Bioorg Med Chem. 2008 Apr 15;16(8):4661-9. DMNLCUH RU https://pubmed.ncbi.nlm.nih.gov/18296055 DM9DA8O DI DM9DA8O DM9DA8O DN Rac-trans-N-oleoylcyclopropanolamide DM9DA8O MI TT6OEDT DM9DA8O MN Cannabinoid receptor 1 (CB1) DM9DA8O MT DTT DM9DA8O MA Inhibitor DM9DA8O RN Conformationally constrained fatty acid ethanolamides as cannabinoid and vanilloid receptor probes. J Med Chem. 2009 May 14;52(9):3001-9. DM9DA8O RU https://pubmed.ncbi.nlm.nih.gov/19361197 DM9DA8O DI DM9DA8O DM9DA8O DN Rac-trans-N-oleoylcyclopropanolamide DM9DA8O MI TTMSFAW DM9DA8O MN Cannabinoid receptor 2 (CB2) DM9DA8O MT DTT DM9DA8O MA Inhibitor DM9DA8O RN Conformationally constrained fatty acid ethanolamides as cannabinoid and vanilloid receptor probes. J Med Chem. 2009 May 14;52(9):3001-9. DM9DA8O RU https://pubmed.ncbi.nlm.nih.gov/19361197 DMNZS94 DI DMNZS94 DMNZS94 DN Radicicol DMNZS94 MI TT78R5H DMNZS94 MN Heat shock protein 90 alpha (HSP90A) DMNZS94 MT DTT DMNZS94 MA Inhibitor DMNZS94 RN High-throughput screening assay for inhibitors of heat-shock protein 90 ATPase activity. Anal Biochem. 2004 Apr 15;327(2):176-83. DMNZS94 RU https://pubmed.ncbi.nlm.nih.gov/15051534 DMVHDOS DI DMVHDOS DMVHDOS DN Raffinose DMVHDOS MI DEJRWQ6 DMVHDOS MN Alpha-galactosidase (melA) DMVHDOS MT DME DMVHDOS MA Metabolism DMVHDOS RN Crystal structure of alpha-galactosidase from Lactobacillus acidophilus NCFM: insight into tetramer formation and substrate binding. J Mol Biol. 2011 Sep 23;412(3):466-80. DMVHDOS RU https://pubmed.ncbi.nlm.nih.gov/21827767 DMVHDOS DI DMVHDOS DMVHDOS DN Raffinose DMVHDOS MI DEUOBTJ DMVHDOS MN Alpha-galactosidase (melA) DMVHDOS MT DME DMVHDOS MA Metabolism DMVHDOS RN Use of an alpha-galactosidase gene as a food-grade selection marker for Streptococcus thermophilus. J Dairy Sci. 2005 Jul;88(7):2341-7. DMVHDOS RU https://pubmed.ncbi.nlm.nih.gov/15956297 DMVHDOS DI DMVHDOS DMVHDOS DN Raffinose DMVHDOS MI DE5EODL DMVHDOS MN Beta-fructofuranosidase (BFRU) DMVHDOS MT DME DMVHDOS MA Metabolism DMVHDOS RN Alpha-glactosidase activity of lactobacilli. Appl Microbiol. 1973 Nov;26(5):783-8. DMVHDOS RU https://pubmed.ncbi.nlm.nih.gov/4796954 DMVHDOS DI DMVHDOS DMVHDOS DN Raffinose DMVHDOS MI DER8TO2 DMVHDOS MN Beta-fructofuranosidase (BFRU) DMVHDOS MT DME DMVHDOS MA Metabolism DMVHDOS RN Alpha-glactosidase activity of lactobacilli. Appl Microbiol. 1973 Nov;26(5):783-8. DMVHDOS RU https://pubmed.ncbi.nlm.nih.gov/4796954 DMVHDOS DI DMVHDOS DMVHDOS DN Raffinose DMVHDOS MI DEET5ZQ DMVHDOS MN Beta-fructofuranosidase (BFRU) DMVHDOS MT DME DMVHDOS MA Metabolism DMVHDOS RN Alpha-glactosidase activity of lactobacilli. Appl Microbiol. 1973 Nov;26(5):783-8. DMVHDOS RU https://pubmed.ncbi.nlm.nih.gov/4796954 DMVHDOS DI DMVHDOS DMVHDOS DN Raffinose DMVHDOS MI DEBUN2V DMVHDOS MN Beta-galactosidase (bgaB) DMVHDOS MT DME DMVHDOS MA Metabolism DMVHDOS RN Differential proteome and cellular adhesion analyses of the probiotic bacterium Lactobacillus acidophilus NCFM grown on raffinose - an emerging prebiotic. Proteomics. 2016 May;16(9):1361-75. DMVHDOS RU https://pubmed.ncbi.nlm.nih.gov/26959526 DMVHDOS DI DMVHDOS DMVHDOS DN Raffinose DMVHDOS MI DE4IPGZ DMVHDOS MN Sucrose phosphorylase (Spase) DMVHDOS MT DME DMVHDOS MA Metabolism DMVHDOS RN Differential proteome and cellular adhesion analyses of the probiotic bacterium Lactobacillus acidophilus NCFM grown on raffinose - an emerging prebiotic. Proteomics. 2016 May;16(9):1361-75. DMVHDOS RU https://pubmed.ncbi.nlm.nih.gov/26959526 DMI7NAF DI DMI7NAF DMI7NAF DN ranatensin DMI7NAF MI TTHYDUM DMI7NAF MN Bombesin receptor (BS) DMI7NAF MT DTT DMI7NAF MA Agonist DMI7NAF RN Pharmacology and cell biology of the bombesin receptor subtype 4 (BB4-R). Biochemistry. 1999 Jun 1;38(22):7307-20. DMI7NAF RU https://pubmed.ncbi.nlm.nih.gov/10353842 DMI7NAF DI DMI7NAF DMI7NAF DN ranatensin DMI7NAF MI TTC1MVT DMI7NAF MN Gastrin-releasing peptide receptor (GRPR) DMI7NAF MT DTT DMI7NAF MA Agonist DMI7NAF RN Pharmacology and cell biology of the bombesin receptor subtype 4 (BB4-R). Biochemistry. 1999 Jun 1;38(22):7307-20. DMI7NAF RU https://pubmed.ncbi.nlm.nih.gov/10353842 DM961JG DI DM961JG DM961JG DN RAP-103 DM961JG MI TTFZYTO DM961JG MN C-C chemokine receptor type 2 (CCR2) DM961JG MT DTT DM961JG MA Modulator DM961JG RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 59). DM961JG RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=59 DMP2DMB DI DMP2DMB DMP2DMB DN RAP-310 DMP2DMB MI TTFZYTO DMP2DMB MN C-C chemokine receptor type 2 (CCR2) DMP2DMB MT DTT DMP2DMB MA Modulator DMP2DMB RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 59). DMP2DMB RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=59 DM8GRJK DI DM8GRJK DM8GRJK DN Rapamycin DM8GRJK MI TT7HQAF DM8GRJK MN HUMAN mammalian target of rapamycin (mTOR) DM8GRJK MT DTT DM8GRJK MA Inhibitor DM8GRJK RN Coronaviruses - drug discovery and therapeutic options. Nat Rev Drug Discov. 2016 May;15(5):327-47. DM8GRJK RU https://pubmed.ncbi.nlm.nih.gov/26868298 DMLBP3F DI DMLBP3F DMLBP3F DN Rapamycin complexed with immunophilin FKBP12 DMLBP3F MI TTCJG29 DMLBP3F MN Serine/threonine-protein kinase mTOR (mTOR) DMLBP3F MT DTT DMLBP3F MA Inhibitor DMLBP3F RN Selected novel anticancer treatments targeting cell signaling proteins. Oncologist. 2001;6(6):517-37. DMLBP3F RU https://pubmed.ncbi.nlm.nih.gov/11743214 DM678IB DI DM678IB DM678IB DN Rapamycin Immunosuppressant Drug DM678IB MI TTMW94E DM678IB MN FK506-binding protein 1A (FKBP1A) DM678IB MT DTT DM678IB MA Inhibitor DM678IB RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DM678IB RU https://pubmed.ncbi.nlm.nih.gov/17139284 DM9XOE6 DI DM9XOE6 DM9XOE6 DN rawsonol DM9XOE6 MI TTPADOQ DM9XOE6 MN HMG-CoA reductase (HMGCR) DM9XOE6 MT DTT DM9XOE6 MA Modulator DM9XOE6 RN Bromophenols in Marine Algae and Their Bioactivities DM9XOE6 RU https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3148503 DMPML15 DI DMPML15 DMPML15 DN RAZAXABAN DMPML15 MI TT6L509 DMPML15 MN Coagulation factor IIa (F2) DMPML15 MT DTT DMPML15 MA Inhibitor DMPML15 RN Phenyltriazolinones as potent factor Xa inhibitors. Bioorg Med Chem Lett. 2010 Feb 15;20(4):1373-7. DMPML15 RU https://pubmed.ncbi.nlm.nih.gov/20100660 DMPML15 DI DMPML15 DMPML15 DN RAZAXABAN DMPML15 MI TTFEZ5Q DMPML15 MN Coagulation factor IX (F9) DMPML15 MT DTT DMPML15 MA Inhibitor DMPML15 RN Aminobenzisoxazoles with biaryl P4 moieties as potent, selective, and orally bioavailable factor Xa inhibitors. Bioorg Med Chem Lett. 2006 Apr 1;16(7):1795-8. DMPML15 RU https://pubmed.ncbi.nlm.nih.gov/16434195 DMPML15 DI DMPML15 DMPML15 DN RAZAXABAN DMPML15 MI TT1O264 DMPML15 MN Coagulation factor Va (F5) DMPML15 MT DTT DMPML15 MA Inhibitor DMPML15 RN Aminobenzisoxazoles with biaryl P4 moieties as potent, selective, and orally bioavailable factor Xa inhibitors. Bioorg Med Chem Lett. 2006 Apr 1;16(7):1795-8. DMPML15 RU https://pubmed.ncbi.nlm.nih.gov/16434195 DMPML15 DI DMPML15 DMPML15 DN RAZAXABAN DMPML15 MI TTCIHJA DMPML15 MN Coagulation factor Xa (F10) DMPML15 MT DTT DMPML15 MA Inhibitor DMPML15 RN Discovery of 1-(4-methoxyphenyl)-7-oxo-6-(4-(2-oxopiperidin-1-yl)phenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxamide (apixaban, BMS... J Med Chem. 2007 Nov 1;50(22):5339-56. DMPML15 RU https://pubmed.ncbi.nlm.nih.gov/17914785 DMCEFUW DI DMCEFUW DMCEFUW DN RB 2 DMCEFUW MI TTK0O6Y DMCEFUW MN Ecto-5'-nucleotidase (CD73) DMCEFUW MT DTT DMCEFUW MA Inhibitor DMCEFUW RN Development of potent and selective inhibitors of ecto-5'-nucleotidase based on an anthraquinone scaffold. J Med Chem. 2010 Mar 11;53(5):2076-86. DMCEFUW RU https://pubmed.ncbi.nlm.nih.gov/20146483 DMCEFUW DI DMCEFUW DMCEFUW DN RB 2 DMCEFUW MI TTOZHQC DMCEFUW MN P2Y purinoceptor 2 (P2RY2) DMCEFUW MT DTT DMCEFUW MA Inhibitor DMCEFUW RN Combinatorial synthesis of anilinoanthraquinone derivatives and evaluation as non-nucleotide-derived P2Y2 receptor antagonists. Bioorg Med Chem Lett. 2008 Jan 1;18(1):223-7. DMCEFUW RU https://pubmed.ncbi.nlm.nih.gov/18006312 DMCEFUW DI DMCEFUW DMCEFUW DN RB 2 DMCEFUW MI TTNVSKA DMCEFUW MN P2Y purinoceptor 6 (P2RY6) DMCEFUW MT DTT DMCEFUW MA Inhibitor DMCEFUW RN Development of potent and selective inhibitors of ecto-5'-nucleotidase based on an anthraquinone scaffold. J Med Chem. 2010 Mar 11;53(5):2076-86. DMCEFUW RU https://pubmed.ncbi.nlm.nih.gov/20146483 DMRK3HO DI DMRK3HO DMRK3HO DN RB-105 DMRK3HO MI TTL69WB DMRK3HO MN Angiotensin-converting enzyme (ACE) DMRK3HO MT DTT DMRK3HO MA Modulator DMRK3HO RN Reversal of cardiac hypertrophy and fibrosis by S21402, a dual inhibitor of neutral endopeptidase and angiotensin converting enzyme in SHRs. J Hypertens. 2000 Jun;18(6):749-55. DMRK3HO RU https://www.ncbi.nlm.nih.gov/pubmed/10872560 DMRK3HO DI DMRK3HO DMRK3HO DN RB-105 DMRK3HO MI TT5TKPM DMRK3HO MN Neutral endopeptidase (MME) DMRK3HO MT DTT DMRK3HO MA Modulator DMRK3HO RN Reversal of cardiac hypertrophy and fibrosis by S21402, a dual inhibitor of neutral endopeptidase and angiotensin converting enzyme in SHRs. J Hypertens. 2000 Jun;18(6):749-55. DMRK3HO RU https://www.ncbi.nlm.nih.gov/pubmed/10872560 DMJDE6Y DI DMJDE6Y DMJDE6Y DN RB-400 DMJDE6Y MI TTVFO0U DMJDE6Y MN Gastrin/cholecystokinin type B receptor (CCKBR) DMJDE6Y MT DTT DMJDE6Y MA Agonist DMJDE6Y RN Synthesis and biological characterisation of [3H]BBL454, a new CCK2 selective radiolabelled agonist displaying original pharmacological properties. Bioorg Med Chem Lett. 2004 Jan 19;14(2):369-72. DMJDE6Y RU https://pubmed.ncbi.nlm.nih.gov/14698161 DM9IQXM DI DM9IQXM DM9IQXM DN RBI257 DM9IQXM MI TTE0A2F DM9IQXM MN Dopamine D4 receptor (D4R) DM9IQXM MT DTT DM9IQXM MA Antagonist DM9IQXM RN Certain 1,4-disubstituted aromatic piperidines and piperazines with extreme selectivity for the dopamine D4 receptor interact with a common recepto... Mol Pharmacol. 2004 Dec;66(6):1491-9. DM9IQXM RU https://pubmed.ncbi.nlm.nih.gov/15448188 DMNEK79 DI DMNEK79 DMNEK79 DN RBx-343E48F0 DMNEK79 MI TTOXS3C DMNEK79 MN Muscarinic acetylcholine receptor (CHRM) DMNEK79 MT DTT DMNEK79 MA Modulator DMNEK79 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 17). DMNEK79 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=17 DM6FVZW DI DM6FVZW DM6FVZW DN R-dimethindene DM6FVZW MI TTTIBOJ DM6FVZW MN Histamine H1 receptor (H1R) DM6FVZW MT DTT DM6FVZW MA Inhibitor DM6FVZW RN Characterization of novel selective H1-antihistamines for clinical evaluation in the treatment of insomnia. J Med Chem. 2009 Sep 10;52(17):5307-10. DM6FVZW RU https://pubmed.ncbi.nlm.nih.gov/19663387 DM6FVZW DI DM6FVZW DM6FVZW DN R-dimethindene DM6FVZW MI TTZ9SOR DM6FVZW MN Muscarinic acetylcholine receptor M1 (CHRM1) DM6FVZW MT DTT DM6FVZW MA Inhibitor DM6FVZW RN Characterization of novel selective H1-antihistamines for clinical evaluation in the treatment of insomnia. J Med Chem. 2009 Sep 10;52(17):5307-10. DM6FVZW RU https://pubmed.ncbi.nlm.nih.gov/19663387 DM6FVZW DI DM6FVZW DM6FVZW DN R-dimethindene DM6FVZW MI TTQ6VDM DM6FVZW MN Voltage-gated potassium channel Kv11.1 (KCNH2) DM6FVZW MT DTT DM6FVZW MA Inhibitor DM6FVZW RN Characterization of novel selective H1-antihistamines for clinical evaluation in the treatment of insomnia. J Med Chem. 2009 Sep 10;52(17):5307-10. DM6FVZW RU https://pubmed.ncbi.nlm.nih.gov/19663387 DM386JM DI DM386JM DM386JM DN Rec 15/2615 DM386JM MI TTBRKXS DM386JM MN Adrenergic receptor alpha-1B (ADRA1B) DM386JM MT DTT DM386JM MA Antagonist DM386JM RN Pharmacological characterization of the uroselective alpha-1 antagonist Rec 15/2739 (SB 216469): role of the alpha-1L adrenoceptor in tissue selectivity, part II. J Pharmacol Exp Ther. 1997 Jun;281(3):1284-93. DM386JM RU https://pubmed.ncbi.nlm.nih.gov/9190864 DMJ0FCG DI DMJ0FCG DMJ0FCG DN REC2615 DMJ0FCG MI TTNGILX DMJ0FCG MN Adrenergic receptor alpha-1A (ADRA1A) DMJ0FCG MT DTT DMJ0FCG MA Antagonist DMJ0FCG RN Designing drugs for the treatment of female sexual dysfunction. Drug Discov Today. 2007 Sep;12(17-18):757-66. DMJ0FCG RU https://pubmed.ncbi.nlm.nih.gov/17826689 DM1P830 DI DM1P830 DM1P830 DN recAAT, PPL Therapeutics/Bayer DM1P830 MI TT2WR1T DM1P830 MN Cationic trypsinogen (PRSS1) DM1P830 MT DTT DM1P830 MA Modulator DM1P830 RN Reduction in neutrophil elastase concentration by recombinant alphal-antitrypsin (recAAT) does not alter bacterial loading in the sputum of cystic ... Br J Biomed Sci. 2004;61(3):146-7. DM1P830 RU https://www.ncbi.nlm.nih.gov/pubmed/15462261 DM1XFE9 DI DM1XFE9 DM1XFE9 DN RECALL-VAX DM1XFE9 MI TTE4KHA DM1XFE9 MN Amyloid beta A4 protein (APP) DM1XFE9 MT DTT DM1XFE9 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2402). DM1XFE9 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2402 DM4B6FO DI DM4B6FO DM4B6FO DN Receptor-Fc fusion proteins DM4B6FO MI TTWMIDN DM4B6FO MN B-cell-activating factor (TNFSF13B) DM4B6FO MT DTT DM4B6FO RN BAFF: B cell survival factor and emerging therapeutic target for autoimmune disorders. Expert Opin Ther Targets. 2003 Feb;7(1):115-23. DM4B6FO RU https://pubmed.ncbi.nlm.nih.gov/12556207 DMA6VCG DI DMA6VCG DMA6VCG DN Recombinant botulinum toxin DMA6VCG MI TTH18TF DMA6VCG MN Muscarinic acetylcholine receptor M5 (CHRM5) DMA6VCG MT DTT DMA6VCG MA Modulator DMA6VCG RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 467). DMA6VCG RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=467 DMFAST4 DI DMFAST4 DMFAST4 DN Recombinant coagulation factors DMFAST4 MI TTCIHJA DMFAST4 MN Coagulation factor Xa (F10) DMFAST4 MT DTT DMFAST4 MA Modulator DMFAST4 RN Semuloparin for the prevention of venous thromboembolic events in cancer patients. Drugs Today (Barc). 2012 Jul;48(7):451-7. DMFAST4 RU https://pubmed.ncbi.nlm.nih.gov/22844656 DMX6LV3 DI DMX6LV3 DMX6LV3 DN Recombinant Factor X DMX6LV3 MI TTCIHJA DMX6LV3 MN Coagulation factor Xa (F10) DMX6LV3 MT DTT DMX6LV3 MA Modulator DMX6LV3 RN Semuloparin for the prevention of venous thromboembolic events in cancer patients. Drugs Today (Barc). 2012 Jul;48(7):451-7. DMX6LV3 RU https://pubmed.ncbi.nlm.nih.gov/22844656 DMNHOI3 DI DMNHOI3 DMNHOI3 DN Recombinant follicle stimulating hormone DMNHOI3 MI TTZFDBT DMNHOI3 MN Follicle-stimulating hormone receptor (FSHR) DMNHOI3 MT DTT DMNHOI3 MA Modulator DMNHOI3 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 253). DMNHOI3 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=253 DMM3465 DI DMM3465 DMM3465 DN Recombinant human butyrylcholinesterase DMM3465 MI TTEB0GD DMM3465 MN Cholinesterase (BCHE) DMM3465 MT DTT DMM3465 MA Modulator DMM3465 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2471). DMM3465 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2471 DMVJLR3 DI DMVJLR3 DMVJLR3 DN Recombinant human pro-urokinase DMVJLR3 MI TTGY7WI DMVJLR3 MN Urokinase-type plasminogen activator (PLAU) DMVJLR3 MT DTT DMVJLR3 MA Inhibitor DMVJLR3 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2393). DMVJLR3 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2393 DMLYQWV DI DMLYQWV DMLYQWV DN Recombinant human TNF receptor DMLYQWV MI TTG043C DMLYQWV MN Tumor necrosis factor receptor type I (TNF-R1) DMLYQWV MT DTT DMLYQWV MA Modulator DMLYQWV RN Secretion of a TNFR:Fc fusion protein following pulmonary administration of pseudotyped adeno-associated virus vectors. J Virol. 2004 Nov;78(22):12355-65. DMLYQWV RU https://pubmed.ncbi.nlm.nih.gov/15507622 DMJQ7XD DI DMJQ7XD DMJQ7XD DN Recombinant TSH superagonists DMJQ7XD MI TT6NYJA DMJQ7XD MN Thyrotropin receptor (TSHR) DMJQ7XD MT DTT DMJQ7XD MA Agonist DMJQ7XD RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 255). DMJQ7XD RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=255 DM2S496 DI DM2S496 DM2S496 DN Redoxal DM2S496 MI TT6EO5L DM2S496 MN Erbb2 tyrosine kinase receptor (HER2) DM2S496 MT DTT DM2S496 RN A new human antitumor immunoreagent specific for ErbB2. Clin Cancer Res. 2002 Jun;8(6):1710-9. DM2S496 RU https://pubmed.ncbi.nlm.nih.gov/12060608 DM2S496 DI DM2S496 DM2S496 DN Redoxal DM2S496 MI TT3PQ2Y DM2S496 MN Plasmodium Dihydroorotate dehydrogenase (Malaria DHOdehase) DM2S496 MT DTT DM2S496 MA Inhibitor DM2S496 RN Malarial dihydroorotate dehydrogenase. Substrate and inhibitor specificity. J Biol Chem. 2002 Nov 1;277(44):41827-34. DM2S496 RU https://pubmed.ncbi.nlm.nih.gov/12189151 DMQ3ER0 DI DMQ3ER0 DMQ3ER0 DN reglitazar DMQ3ER0 MI TTJ584C DMQ3ER0 MN Peroxisome proliferator-activated receptor alpha (PPARA) DMQ3ER0 MT DTT DMQ3ER0 MA Agonist DMQ3ER0 RN Pharmacological profiles of a novel oral antidiabetic agent, JTT-501, an isoxazolidinedione derivative. Eur J Pharmacol. 1999 Jan 8;364(2-3):211-9. DMQ3ER0 RU https://pubmed.ncbi.nlm.nih.gov/9932726 DMQ3ER0 DI DMQ3ER0 DMQ3ER0 DN reglitazar DMQ3ER0 MI TTT2SVW DMQ3ER0 MN PPAR-gamma messenger RNA (PPARG mRNA) DMQ3ER0 MT DTT DMQ3ER0 MA Agonist DMQ3ER0 RN Pharmacological profiles of a novel oral antidiabetic agent, JTT-501, an isoxazolidinedione derivative. Eur J Pharmacol. 1999 Jan 8;364(2-3):211-9. DMQ3ER0 RU https://pubmed.ncbi.nlm.nih.gov/9932726 DM3AWPB DI DM3AWPB DM3AWPB DN Relcovaptan DM3AWPB MI TT4TFGN DM3AWPB MN Vasopressin V1a receptor (V1AR) DM3AWPB MT DTT DM3AWPB MA Inhibitor DM3AWPB RN Binding of [3H] SR 49059, a potent nonpeptide vasopressin V1a antagonist, to rat and human liver membranes. Biochem Biophys Res Commun. 1994 Feb 28;199(1):353-60. DM3AWPB RU https://pubmed.ncbi.nlm.nih.gov/8123034 DM47TSV DI DM47TSV DM47TSV DN Repinotan DM47TSV MI TTSQIFT DM47TSV MN 5-HT 1A receptor (HTR1A) DM47TSV MT DTT DM47TSV MA Antagonist DM47TSV RN Characterization of the aminomethylchroman derivative BAY x 3702 as a highly potent 5-hydroxytryptamine1A receptor agonist. J Pharmacol Exp Ther. 1998 Mar;284(3):1082-94. DM47TSV RU https://pubmed.ncbi.nlm.nih.gov/9495870 DM47TSV DI DM47TSV DM47TSV DN Repinotan DM47TSV MI DECB0K3 DM47TSV MN Cytochrome P450 2D6 (CYP2D6) DM47TSV MT DME DM47TSV MA Metabolism DM47TSV RN Evaluation of interethnic differences in repinotan pharmacokinetics by using population approach. Drug Metab Pharmacokinet. 2006 Feb;21(1):61-9. DM47TSV RU https://www.ncbi.nlm.nih.gov/pubmed/?term=16547395 DMQEBKF DI DMQEBKF DMQEBKF DN RES-701-1-C-terminal analogue DMQEBKF MI TT3ZTGU DMQEBKF MN Endothelin B receptor (EDNRB) DMQEBKF MT DTT DMQEBKF MA Inhibitor DMQEBKF RN Analogs of an endothelin antagonist RES-701-1: substitutions of C-terminal amino acid, Bioorg. Med. Chem. Lett. 6(7):775-778 (1996). DMQEBKF RU http://www.sciencedirect.com/science/article/pii/0960894X96001278 DM2IBND DI DM2IBND DM2IBND DN RESCOVITINE DM2IBND MI TTAMQ62 DM2IBND MN Cyclin A2 (CCNA2) DM2IBND MT DTT DM2IBND MA Inhibitor DM2IBND RN Design, synthesis, and biological evaluation of novel pyrimidine derivatives as CDK2 inhibitors. Eur J Med Chem. 2010 Mar;45(3):1158-66. DM2IBND RU https://pubmed.ncbi.nlm.nih.gov/20045222 DM2IBND DI DM2IBND DM2IBND DN RESCOVITINE DM2IBND MI TT7HF4W DM2IBND MN Cyclin-dependent kinase 2 (CDK2) DM2IBND MT DTT DM2IBND MA Inhibitor DM2IBND RN Design, synthesis, and biological evaluation of novel pyrimidine derivatives as CDK2 inhibitors. Eur J Med Chem. 2010 Mar;45(3):1158-66. DM2IBND RU https://pubmed.ncbi.nlm.nih.gov/20045222 DMLVU6H DI DMLVU6H DMLVU6H DN resolvin D2 DMLVU6H MI TTELV3W DMLVU6H MN Transformation-sensitive protein p120 (TRPA1) DMLVU6H MT DTT DMLVU6H MA Inhibitor (gating inhibitor) DMLVU6H RN Resolvin D2 is a potent endogenous inhibitor for transient receptor potential subtype V1/A1, inflammatory pain, and spinal cord synaptic plasticity in mice: distinct roles of resolvin D1, D2, and E1.J Neurosci. 2011 Dec 14;31(50):18433-8. DMLVU6H RU https://pubmed.ncbi.nlm.nih.gov/22171045 DMM37C0 DI DMM37C0 DMM37C0 DN Resorcinol DMM37C0 MI TTUNARX DMM37C0 MN Carbonic anhydrase (CA) DMM37C0 MT DTT DMM37C0 MA Inhibitor DMM37C0 RN Carbonic anhydrase inhibitors: inhibition of mammalian isoforms I-XIV with a series of substituted phenols including paracetamol and salicylic acid. Bioorg Med Chem. 2008 Aug 1;16(15):7424-8. DMM37C0 RU https://pubmed.ncbi.nlm.nih.gov/18579385 DMM37C0 DI DMM37C0 DMM37C0 DN Resorcinol DMM37C0 MI TTANPDJ DMM37C0 MN Carbonic anhydrase II (CA-II) DMM37C0 MT DTT DMM37C0 MA Inhibitor DMM37C0 RN Carbonic anhydrase inhibitors: inhibition of mammalian isoforms I-XIV with a series of substituted phenols including paracetamol and salicylic acid. Bioorg Med Chem. 2008 Aug 1;16(15):7424-8. DMM37C0 RU https://pubmed.ncbi.nlm.nih.gov/18579385 DMM37C0 DI DMM37C0 DMM37C0 DN Resorcinol DMM37C0 MI TTSYM0R DMM37C0 MN Carbonic anhydrase XII (CA-XII) DMM37C0 MT DTT DMM37C0 MA Inhibitor DMM37C0 RN Carbonic anhydrase inhibitors: inhibition of mammalian isoforms I-XIV with a series of substituted phenols including paracetamol and salicylic acid. Bioorg Med Chem. 2008 Aug 1;16(15):7424-8. DMM37C0 RU https://pubmed.ncbi.nlm.nih.gov/18579385 DMM37C0 DI DMM37C0 DMM37C0 DN Resorcinol DMM37C0 MI TTEYTKG DMM37C0 MN Carbonic anhydrase XIV (CA-XIV) DMM37C0 MT DTT DMM37C0 MA Inhibitor DMM37C0 RN Carbonic anhydrase inhibitors: inhibition of mammalian isoforms I-XIV with a series of substituted phenols including paracetamol and salicylic acid. Bioorg Med Chem. 2008 Aug 1;16(15):7424-8. DMM37C0 RU https://pubmed.ncbi.nlm.nih.gov/18579385 DMM37C0 DI DMM37C0 DMM37C0 DN Resorcinol DMM37C0 MI DEWRN24 DMM37C0 MN Glucansucrase (gtf106B) DMM37C0 MT DME DMM37C0 MA Metabolism DMM37C0 RN Increased infections with beta-blocker use in ischemic stroke, a beta2-receptor mediated process? Neurol Sci. 2017 Jun;38(6):967-974. DMM37C0 RU https://pubmed.ncbi.nlm.nih.gov/28258316 DMM37C0 DI DMM37C0 DMM37C0 DN Resorcinol DMM37C0 MI TT8NGED DMM37C0 MN Prostaglandin G/H synthase 1 (COX-1) DMM37C0 MT DTT DMM37C0 MA Inhibitor DMM37C0 RN Mechanism-based inactivation of COX-1 by red wine m-hydroquinones: a structure-activity relationship study. J Nat Prod. 2004 Nov;67(11):1777-82. DMM37C0 RU https://pubmed.ncbi.nlm.nih.gov/15568761 DMN1RLA DI DMN1RLA DMN1RLA DN Resveratrol Potassium3-Sulfate DMN1RLA MI TT8NGED DMN1RLA MN Prostaglandin G/H synthase 1 (COX-1) DMN1RLA MT DTT DMN1RLA MA Inhibitor DMN1RLA RN Selective synthesis and biological evaluation of sulfate-conjugated resveratrol metabolites. J Med Chem. 2010 Jul 8;53(13):5033-43. DMN1RLA RU https://pubmed.ncbi.nlm.nih.gov/20527891 DMN1RLA DI DMN1RLA DMN1RLA DN Resveratrol Potassium3-Sulfate DMN1RLA MI TTVKILB DMN1RLA MN Prostaglandin G/H synthase 2 (COX-2) DMN1RLA MT DTT DMN1RLA MA Inhibitor DMN1RLA RN Selective synthesis and biological evaluation of sulfate-conjugated resveratrol metabolites. J Med Chem. 2010 Jul 8;53(13):5033-43. DMN1RLA RU https://pubmed.ncbi.nlm.nih.gov/20527891 DMMFP57 DI DMMFP57 DMMFP57 DN Resveratrol Potassium4,-Sulfate DMMFP57 MI TTF10I9 DMMFP57 MN Nitric-oxide synthase inducible (NOS2) DMMFP57 MT DTT DMMFP57 MA Inhibitor DMMFP57 RN Selective synthesis and biological evaluation of sulfate-conjugated resveratrol metabolites. J Med Chem. 2010 Jul 8;53(13):5033-43. DMMFP57 RU https://pubmed.ncbi.nlm.nih.gov/20527891 DMMFP57 DI DMMFP57 DMMFP57 DN Resveratrol Potassium4,-Sulfate DMMFP57 MI TT8NGED DMMFP57 MN Prostaglandin G/H synthase 1 (COX-1) DMMFP57 MT DTT DMMFP57 MA Inhibitor DMMFP57 RN Selective synthesis and biological evaluation of sulfate-conjugated resveratrol metabolites. J Med Chem. 2010 Jul 8;53(13):5033-43. DMMFP57 RU https://pubmed.ncbi.nlm.nih.gov/20527891 DMMFP57 DI DMMFP57 DMMFP57 DN Resveratrol Potassium4,-Sulfate DMMFP57 MI TTVKILB DMMFP57 MN Prostaglandin G/H synthase 2 (COX-2) DMMFP57 MT DTT DMMFP57 MA Inhibitor DMMFP57 RN Selective synthesis and biological evaluation of sulfate-conjugated resveratrol metabolites. J Med Chem. 2010 Jul 8;53(13):5033-43. DMMFP57 RU https://pubmed.ncbi.nlm.nih.gov/20527891 DMQFSI5 DI DMQFSI5 DMQFSI5 DN Retagliptin DMQFSI5 MI TTDIGC1 DMQFSI5 MN Dipeptidyl peptidase 4 (DPP-4) DMQFSI5 MT DTT DMQFSI5 MA Inhibitor DMQFSI5 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1612). DMQFSI5 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1612 DMWDNOK DI DMWDNOK DMWDNOK DN REVERSINE DMWDNOK MI TTJFY5U DMWDNOK MN Adenosine A3 receptor (ADORA3) DMWDNOK MT DTT DMWDNOK MA Inhibitor DMWDNOK RN Reversine and its 2-substituted adenine derivatives as potent and selective A3 adenosine receptor antagonists. J Med Chem. 2005 Jul 28;48(15):4910-8. DMWDNOK RU https://pubmed.ncbi.nlm.nih.gov/16033270 DMWDNOK DI DMWDNOK DMWDNOK DN REVERSINE DMWDNOK MI TTIDAPM DMWDNOK MN ERK activator kinase 1 (MEK1) DMWDNOK MT DTT DMWDNOK MA Inhibitor DMWDNOK RN Reversine increases the plasticity of lineage-committed mammalian cells. Proc Natl Acad Sci U S A. 2007 Jun 19;104(25):10482-7. DMWDNOK RU https://pubmed.ncbi.nlm.nih.gov/17566101 DM3IXEA DI DM3IXEA DM3IXEA DN RF9 DM3IXEA MI TTEP027 DM3IXEA MN Neuropeptide FF receptor 1 (NPFFR1) DM3IXEA MT DTT DM3IXEA MA Antagonist DM3IXEA RN RF9, a potent and selective neuropeptide FF receptor antagonist, prevents opioid-induced tolerance associated with hyperalgesia. Proc Natl Acad Sci U S A. 2006 Jan 10;103(2):466-71. DM3IXEA RU https://pubmed.ncbi.nlm.nih.gov/16407169 DM3IXEA DI DM3IXEA DM3IXEA DN RF9 DM3IXEA MI TTXYNDJ DM3IXEA MN Neuropeptide FF receptor 2 (NPFFR2) DM3IXEA MT DTT DM3IXEA MA Antagonist DM3IXEA RN RF9, a potent and selective neuropeptide FF receptor antagonist, prevents opioid-induced tolerance associated with hyperalgesia. Proc Natl Acad Sci U S A. 2006 Jan 10;103(2):466-71. DM3IXEA RU https://pubmed.ncbi.nlm.nih.gov/16407169 DMJG4U0 DI DMJG4U0 DMJG4U0 DN R-fadrozole DMJG4U0 MI TTIQUX7 DMJG4U0 MN Steroid 11-beta-hydroxylase (CYP11B1) DMJG4U0 MT DTT DMJG4U0 MA Inhibitor DMJG4U0 RN Synthesis, biological evaluation, and molecular modeling of 1-benzyl-1H-imidazoles as selective inhibitors of aldosterone synthase (CYP11B2). J Med Chem. 2010 Feb 25;53(4):1712-25. DMJG4U0 RU https://pubmed.ncbi.nlm.nih.gov/20121113 DMUR9LM DI DMUR9LM DMUR9LM DN RG-50810 DMUR9LM MI TTGKNB4 DMUR9LM MN Epidermal growth factor receptor (EGFR) DMUR9LM MT DTT DMUR9LM MA Inhibitor DMUR9LM RN Protein-tyrosine kinase inhibition: mechanism-based discovery of antitumor agents. J Nat Prod. 1992 Nov;55(11):1529-60. DMUR9LM RU https://pubmed.ncbi.nlm.nih.gov/1479375 DMGYWIK DI DMGYWIK DMGYWIK DN RG6046 DMGYWIK MI TTZAYWL DMGYWIK MN Estrogen receptor (ESR) DMGYWIK MT DTT DMGYWIK MA Modulator DMGYWIK RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015 DMGYWIK RU https://www.accessdata.fda.gov/scripts/cder/drugsatfda/ DMSTL12 DI DMSTL12 DMSTL12 DN RG7232 DMSTL12 MI TTJW1GN DMSTL12 MN ATP-binding cassette transporter A1 (ABCA1) DMSTL12 MT DTT DMSTL12 MA Modulator DMSTL12 RN Analysis of "On/Off" Kinetics of a CETP Inhibitor Using a Mechanistic Model of Lipoprotein Metabolism and Kinetics. CPT Pharmacometrics Syst Pharmacol. 2015 Aug;4(8):465-73. DMSTL12 RU https://pubmed.ncbi.nlm.nih.gov/26380155 DMP08BY DI DMP08BY DMP08BY DN RGB-286147 DMP08BY MI TTO0FDJ DMP08BY MN Cyclin-dependent kinase 6 (CDK6) DMP08BY MT DTT DMP08BY MA Inhibitor DMP08BY RN A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases. Proc Natl Acad Sci U S A. 2007 Dec 18;104(51):20523-8. DMP08BY RU https://pubmed.ncbi.nlm.nih.gov/18077363 DMP08BY DI DMP08BY DMP08BY DN RGB-286147 DMP08BY MI TTQYF7G DMP08BY MN Cyclin-dependent kinase 7 (CDK7) DMP08BY MT DTT DMP08BY MA Inhibitor DMP08BY RN A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases. Proc Natl Acad Sci U S A. 2007 Dec 18;104(51):20523-8. DMP08BY RU https://pubmed.ncbi.nlm.nih.gov/18077363 DMP08BY DI DMP08BY DMP08BY DN RGB-286147 DMP08BY MI TTRSMW9 DMP08BY MN Glycogen synthase kinase-3 beta (GSK-3B) DMP08BY MT DTT DMP08BY MA Inhibitor DMP08BY RN A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases. Proc Natl Acad Sci U S A. 2007 Dec 18;104(51):20523-8. DMP08BY RU https://pubmed.ncbi.nlm.nih.gov/18077363 DMFASRB DI DMFASRB DMFASRB DN RGD DMFASRB MI TT38RM1 DMFASRB MN Glycoprotein IIb/IIIa receptor (GPIIb/IIIa) DMFASRB MT DTT DMFASRB MA Binder DMFASRB RN AlphaIIbbeta3 and its antagonism at the new millennium. Thromb Haemost. 2001 Jul;86(1):34-40. DMFASRB RU https://pubmed.ncbi.nlm.nih.gov/11487023 DM0O9VG DI DM0O9VG DM0O9VG DN RGD-039 DM0O9VG MI TT38RM1 DM0O9VG MN Glycoprotein IIb/IIIa receptor (GPIIb/IIIa) DM0O9VG MT DTT DM0O9VG MA Modulator DM0O9VG RN Pharmacokinetics and concentration-effect analysis of intravenous RGD891, a platelet GPIIb/IIIa antagonist, using mixed-effects modeling (NONMEM). J Clin Pharmacol. 2000 Oct;40(10):1129-40. DM0O9VG RU https://pubmed.ncbi.nlm.nih.gov/11028252 DMX4JN6 DI DMX4JN6 DMX4JN6 DN RGDechi DMX4JN6 MI TTT1R2L DMX4JN6 MN Integrin alpha-V (ITGAV) DMX4JN6 MT DTT DMX4JN6 MA Inhibitor DMX4JN6 RN Novel and selective alpha(v)beta3 receptor peptide antagonist: design, synthesis, and biological behavior. J Med Chem. 2006 Jun 1;49(11):3416-20. DMX4JN6 RU https://pubmed.ncbi.nlm.nih.gov/16722662 DMX4JN6 DI DMX4JN6 DMX4JN6 DN RGDechi DMX4JN6 MI TTJA1ZO DMX4JN6 MN ITGB3 messenger RNA (ITGB3 mRNA) DMX4JN6 MT DTT DMX4JN6 MA Inhibitor DMX4JN6 RN Novel and selective alpha(v)beta3 receptor peptide antagonist: design, synthesis, and biological behavior. J Med Chem. 2006 Jun 1;49(11):3416-20. DMX4JN6 RU https://pubmed.ncbi.nlm.nih.gov/16722662 DME9T0A DI DME9T0A DME9T0A DN RGFP966 DME9T0A MI TT4YWTO DME9T0A MN Histone deacetylase 3 (HDAC3) DME9T0A MT DTT DME9T0A MA Inhibitor DME9T0A RN HDAC3-selective inhibitor enhances extinction of cocaine-seeking behavior in a persistent manner. Proc Natl Acad Sci U S A. 2013 Feb 12;110(7):2647-52. DME9T0A RU https://pubmed.ncbi.nlm.nih.gov/23297220 DM4XVLB DI DM4XVLB DM4XVLB DN RGS4 inhibitor 13 DM4XVLB MI TTGTKX9 DM4XVLB MN Regulator of G-protein signaling 4 (RGS4) DM4XVLB MT DTT DM4XVLB MA Inhibitor DM4XVLB RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2811). DM4XVLB RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2811 DM4XVLB DI DM4XVLB DM4XVLB DN RGS4 inhibitor 13 DM4XVLB MI TTWME23 DM4XVLB MN Regulator of G-protein signaling 8 (RGS8) DM4XVLB MT DTT DM4XVLB MA Inhibitor DM4XVLB RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2813). DM4XVLB RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2813 DMC471Z DI DMC471Z DMC471Z DN RHC80267 DMC471Z MI TTRQ6UD DMC471Z MN Diacylglycerol lipase alpha (DAGLA) DMC471Z MT DTT DMC471Z MA Inhibitor DMC471Z RN Assay and inhibition of diacylglycerol lipase activity. Bioorg Med Chem Lett. 2012 Jul 15;22(14):4585-92. DMC471Z RU https://pubmed.ncbi.nlm.nih.gov/22738638 DMC471Z DI DMC471Z DMC471Z DN RHC80267 DMC471Z MI TTXZDEN DMC471Z MN Diacylglycerol lipase beta (DAGLB) DMC471Z MT DTT DMC471Z MA Inhibitor DMC471Z RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1397). DMC471Z RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1397 DMS6IJ0 DI DMS6IJ0 DMS6IJ0 DN RHEIN DMS6IJ0 MI TT78R5H DMS6IJ0 MN Heat shock protein 90 alpha (HSP90A) DMS6IJ0 MT DTT DMS6IJ0 MA Inhibitor DMS6IJ0 RN In silico identification and biochemical evaluation of novel inhibitors of NRH:quinone oxidoreductase 2 (NQO2). Bioorg Med Chem Lett. 2010 Dec 15;20(24):7331-6. DMS6IJ0 RU https://pubmed.ncbi.nlm.nih.gov/21074425 DMWP09B DI DMWP09B DMWP09B DN RHIIP DMWP09B MI TTCBFJO DMWP09B MN Insulin receptor (INSR) DMWP09B MT DTT DMWP09B MA Modulator DMWP09B RN PROMAXX inhaled insulin: safe and efficacious administration with a commercially available dry powder inhaler. Diabetes Obes Metab. 2009 May;11(5):455-9. DMWP09B RU https://pubmed.ncbi.nlm.nih.gov/19236443 DMH9QAF DI DMH9QAF DMH9QAF DN RHODIOLININ DMH9QAF MI TT50QJ3 DMH9QAF MN Influenza Neuraminidase (Influ NA) DMH9QAF MT DTT DMH9QAF MA Inhibitor DMH9QAF RN Neuraminidase inhibitory activities of flavonols isolated from Rhodiola rosea roots and their in vitro anti-influenza viral activities. Bioorg Med Chem. 2009 Oct 1;17(19):6816-23. DMH9QAF RU https://pubmed.ncbi.nlm.nih.gov/19729316 DMW1VOB DI DMW1VOB DMW1VOB DN rHuB-D2 DMW1VOB MI TTIVY12 DMW1VOB MN Beta-defensin 4A (DEFB4A) DMW1VOB MT DTT DMW1VOB MA Modulator DMW1VOB RN Bioactive coating of titanium surfaces with recombinant human -defensin-2 (rHuD2) may prevent bacterial colonization in orthopaedic surgery.J Bone Joint Surg Am.2011 May 4;93(9):840-6. DMW1VOB RU https://www.ncbi.nlm.nih.gov/pubmed/21543673 DMSL2CM DI DMSL2CM DMSL2CM DN Ribavirin + interferon alfa-2a DMSL2CM MI TTOA6YT DMSL2CM MN MERS-CoV RNA-directed RNA polymerase (RdRp) DMSL2CM MT DTT DMSL2CM MA Inhibitor DMSL2CM RN Coronaviruses - drug discovery and therapeutic options. Nat Rev Drug Discov. 2016 May;15(5):327-47. DMSL2CM RU https://pubmed.ncbi.nlm.nih.gov/26868298 DMT4JCW DI DMT4JCW DMT4JCW DN Ribavirin + interferon alfa-2b DMT4JCW MI TTOA6YT DMT4JCW MN MERS-CoV RNA-directed RNA polymerase (RdRp) DMT4JCW MT DTT DMT4JCW MA Inhibitor DMT4JCW RN Coronaviruses - drug discovery and therapeutic options. Nat Rev Drug Discov. 2016 May;15(5):327-47. DMT4JCW RU https://pubmed.ncbi.nlm.nih.gov/26868298 DMAQMXT DI DMAQMXT DMAQMXT DN Ribavirin + interferon beta-1a DMAQMXT MI TTOA6YT DMAQMXT MN MERS-CoV RNA-directed RNA polymerase (RdRp) DMAQMXT MT DTT DMAQMXT MA Inhibitor DMAQMXT RN Coronaviruses - drug discovery and therapeutic options. Nat Rev Drug Discov. 2016 May;15(5):327-47. DMAQMXT RU https://pubmed.ncbi.nlm.nih.gov/26868298 DM7DRO4 DI DM7DRO4 DM7DRO4 DN Ribavirin + lopinavir + ritonavir + interferon alfa-2a DM7DRO4 MI TTWOH4Q DM7DRO4 MN MERS-CoV 3C-like proteinase (3CLpro) DM7DRO4 MT DTT DM7DRO4 MA Inhibitor DM7DRO4 RN Coronavirus puts drug repurposing on the fast track. Nat Biotechnol. 2020 Apr;38(4):379-381. DM7DRO4 RU https://pubmed.ncbi.nlm.nih.gov/32205870 DM7DRO4 DI DM7DRO4 DM7DRO4 DN Ribavirin + lopinavir + ritonavir + interferon alfa-2a DM7DRO4 MI TTOA6YT DM7DRO4 MN MERS-CoV RNA-directed RNA polymerase (RdRp) DM7DRO4 MT DTT DM7DRO4 MA Inhibitor DM7DRO4 RN Coronaviruses - drug discovery and therapeutic options. Nat Rev Drug Discov. 2016 May;15(5):327-47. DM7DRO4 RU https://pubmed.ncbi.nlm.nih.gov/26868298 DM09NGV DI DM09NGV DM09NGV DN Ribavirin-TP DM09NGV MI TTWXB3E DM09NGV MN Hepatitis C virus NS3 helicase (HCV NS3) DM09NGV MT DTT DM09NGV MA Inhibitor DM09NGV RN ATP-binding domain of NTPase/helicase as a target for hepatitis C antiviral therapy. Acta Biochim Pol. 2000;47(1):173-80. DM09NGV RU https://pubmed.ncbi.nlm.nih.gov/10961691 DM7V8DZ DI DM7V8DZ DM7V8DZ DN Ribose-1-Phosphate DM7V8DZ MI TTMCF1Y DM7V8DZ MN Purine nucleoside phosphorylase (PNP) DM7V8DZ MT DTT DM7V8DZ MA Inhibitor DM7V8DZ RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DM7V8DZ RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMRKO49 DI DMRKO49 DMRKO49 DN Ribose-5-Phosphate DMRKO49 MI TTVNA43 DMRKO49 MN Bacterial Deoxy-D-manno-octulosonate 8-phosphate synthase (Bact kdsA) DMRKO49 MT DTT DMRKO49 MA Inhibitor DMRKO49 RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMRKO49 RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMXWUHA DI DMXWUHA DMXWUHA DN Ribostamycin DMXWUHA MI TT38DW5 DMXWUHA MN Bacterial 16S ribosomal RNA (Bact 16S rRNA) DMXWUHA MT DTT DMXWUHA MA Inhibitor DMXWUHA RN RNA as a target for small molecules. Curr Opin Chem Biol. 2000 Dec;4(6):678-86. DMXWUHA RU https://pubmed.ncbi.nlm.nih.gov/11102874 DM6MYGX DI DM6MYGX DM6MYGX DN Riccardin C DM6MYGX MI TTECBXN DM6MYGX MN Oxysterols receptor LXR-alpha (NR1H3) DM6MYGX MT DTT DM6MYGX MA Inhibitor DM6MYGX RN Co-existence of alpha-glucosidase-inhibitory and liver X receptor-regulatory activities and their separation by structural development. Bioorg Med Chem. 2008 Apr 15;16(8):4272-85. DM6MYGX RU https://pubmed.ncbi.nlm.nih.gov/18343126 DM6MYGX DI DM6MYGX DM6MYGX DN Riccardin C DM6MYGX MI TTXA6PH DM6MYGX MN Oxysterols receptor LXR-beta (NR1H2) DM6MYGX MT DTT DM6MYGX MA Inhibitor DM6MYGX RN Co-existence of alpha-glucosidase-inhibitory and liver X receptor-regulatory activities and their separation by structural development. Bioorg Med Chem. 2008 Apr 15;16(8):4272-85. DM6MYGX RU https://pubmed.ncbi.nlm.nih.gov/18343126 DM9HMCS DI DM9HMCS DM9HMCS DN Ridine-5-carboxylic acid ethyl ester DM9HMCS MI TT1MPAY DM9HMCS MN GABA(A) receptor alpha-1 (GABRA1) DM9HMCS MT DTT DM9HMCS MA Inhibitor DM9HMCS RN Synthesis and structure-activity relationships of a series of anxioselective pyrazolopyridine ester and amide anxiolytic agents. J Med Chem. 1989 Dec;32(12):2561-73. DM9HMCS RU https://pubmed.ncbi.nlm.nih.gov/2573731 DM9HMCS DI DM9HMCS DM9HMCS DN Ridine-5-carboxylic acid ethyl ester DM9HMCS MI TTZA1NY DM9HMCS MN GABA(A) receptor beta-2 (GABRB2) DM9HMCS MT DTT DM9HMCS MA Inhibitor DM9HMCS RN Synthesis and structure-activity relationships of a series of anxioselective pyrazolopyridine ester and amide anxiolytic agents. J Med Chem. 1989 Dec;32(12):2561-73. DM9HMCS RU https://pubmed.ncbi.nlm.nih.gov/2573731 DM9HMCS DI DM9HMCS DM9HMCS DN Ridine-5-carboxylic acid ethyl ester DM9HMCS MI TT06RH5 DM9HMCS MN GABA(A) receptor gamma-2 (GABRG2) DM9HMCS MT DTT DM9HMCS MA Inhibitor DM9HMCS RN Synthesis and structure-activity relationships of a series of anxioselective pyrazolopyridine ester and amide anxiolytic agents. J Med Chem. 1989 Dec;32(12):2561-73. DM9HMCS RU https://pubmed.ncbi.nlm.nih.gov/2573731 DM9HMCS DI DM9HMCS DM9HMCS DN Ridine-5-carboxylic acid ethyl ester DM9HMCS MI TTNJYV2 DM9HMCS MN Gamma-aminobutyric acid receptor (GAR) DM9HMCS MT DTT DM9HMCS MA Inhibitor DM9HMCS RN Synthesis and structure-activity relationships of a series of anxioselective pyrazolopyridine ester and amide anxiolytic agents. J Med Chem. 1989 Dec;32(12):2561-73. DM9HMCS RU https://pubmed.ncbi.nlm.nih.gov/2573731 DMN98U1 DI DMN98U1 DMN98U1 DN Rimantadine isomer 1 DMN98U1 MI TTXT3PU DMN98U1 MN Influenza M2 protein (Influ M) DMN98U1 MT DTT DMN98U1 MA Inhibitor DMN98U1 RN Antiviral agents active against influenza A viruses. Nat Rev Drug Discov. 2006 Dec;5(12):1015-25. DMN98U1 RU https://pubmed.ncbi.nlm.nih.gov/17139286 DM3BEF7 DI DM3BEF7 DM3BEF7 DN Rimantadine isomer 2 DM3BEF7 MI TTXT3PU DM3BEF7 MN Influenza M2 protein (Influ M) DM3BEF7 MT DTT DM3BEF7 MA Inhibitor DM3BEF7 RN Antiviral agents active against influenza A viruses. Nat Rev Drug Discov. 2006 Dec;5(12):1015-25. DM3BEF7 RU https://pubmed.ncbi.nlm.nih.gov/17139286 DM59G40 DI DM59G40 DM59G40 DN Rimeporide DM59G40 MI TT70SZ3 DM59G40 MN Sodium/hydrogen exchanger (SLC) DM59G40 MT DTT DM59G40 MA Inhibitor DM59G40 RN Sodium-hydrogen exchanger, cardiac overload, and myocardial hypertrophy. Circulation. 2007 Mar 6;115(9):1090-100. DM59G40 RU https://pubmed.ncbi.nlm.nih.gov/17339567 DM83L5Y DI DM83L5Y DM83L5Y DN RIP DM83L5Y MI TTL69WB DM83L5Y MN Angiotensin-converting enzyme (ACE) DM83L5Y MT DTT DM83L5Y MA Inhibitor DM83L5Y RN Difluorostatine- and difluorostatone-containing peptides as potent and specific renin inhibitors. J Med Chem. 1985 Nov;28(11):1553-5. DM83L5Y RU https://pubmed.ncbi.nlm.nih.gov/3906126 DMYIQRK DI DMYIQRK DMYIQRK DN RIPA-56 DMYIQRK MI TTAIQSN DMYIQRK MN Receptor-interacting protein 1 (RIPK1) DMYIQRK MT DTT DMYIQRK MA Inhibitor DMYIQRK RN Inhibition of receptor-interacting protein kinase 1 improves experimental non-alcoholic fatty liver disease. J Hepatol. 2020 Apr;72(4):627-635. DMYIQRK RU https://pubmed.ncbi.nlm.nih.gov/31760070 DMTHVQD DI DMTHVQD DMTHVQD DN RIPAZEPAM DMTHVQD MI TT1MPAY DMTHVQD MN GABA(A) receptor alpha-1 (GABRA1) DMTHVQD MT DTT DMTHVQD MA Inhibitor DMTHVQD RN Synthesis and interaction of 5-(substituted-phenyl)-3-methyl-6,7-dihydropyrazolo[4,3-e] [1,4]diazepin-8(7H)-ones with benzodiazepine receptors in r... J Med Chem. 1985 May;28(5):683-5. DMTHVQD RU https://pubmed.ncbi.nlm.nih.gov/2985787 DMTHVQD DI DMTHVQD DMTHVQD DN RIPAZEPAM DMTHVQD MI TTNJYV2 DMTHVQD MN Gamma-aminobutyric acid receptor (GAR) DMTHVQD MT DTT DMTHVQD MA Inhibitor DMTHVQD RN Synthesis and interaction of 5-(substituted-phenyl)-3-methyl-6,7-dihydropyrazolo[4,3-e] [1,4]diazepin-8(7H)-ones with benzodiazepine receptors in r... J Med Chem. 1985 May;28(5):683-5. DMTHVQD RU https://pubmed.ncbi.nlm.nih.gov/2985787 DMJD3WY DI DMJD3WY DMJD3WY DN RI-TPO DMJD3WY MI TTIHYA4 DMJD3WY MN Thrombopoietin receptor (MPL) DMJD3WY MT DTT DMJD3WY MA Modulator DMJD3WY RN The ChEMBL database in 2017. Nucleic Acids Res. 2017 Jan 4;45(D1):D945-D954. DMJD3WY RU https://www.ncbi.nlm.nih.gov/pubmed/27899562 DM2P6I8 DI DM2P6I8 DM2P6I8 DN RJM-0035-K002 DM2P6I8 MI TTL69WB DM2P6I8 MN Angiotensin-converting enzyme (ACE) DM2P6I8 MT DTT DM2P6I8 MA Inhibitor DM2P6I8 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1613). DM2P6I8 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1613 DM5CI2P DI DM5CI2P DM5CI2P DN RK-682 DM5CI2P MI TTELIN2 DM5CI2P MN PTPN1 messenger RNA (PTPN1 mRNA) DM5CI2P MT DTT DM5CI2P MA Inhibitor DM5CI2P RN Prenylflavonoids from Glycyrrhiza uralensis and their protein tyrosine phosphatase-1B inhibitory activities. Bioorg Med Chem Lett. 2010 Sep 15;20(18):5398-401. DM5CI2P RU https://pubmed.ncbi.nlm.nih.gov/20724155 DMGTAWC DI DMGTAWC DMGTAWC DN RKI-1447 DMGTAWC MI TT5Z0EF DMGTAWC MN CDC42 binding protein kinase alpha (DMPK-like alpha) DMGTAWC MT DTT DMGTAWC MA Inhibitor DMGTAWC RN Pyridylthiazole-based ureas as inhibitors of Rho associated protein kinases (ROCK1 and 2). Medchemcomm. 2012 Jun 1;3(6):699-709. DMGTAWC RU https://pubmed.ncbi.nlm.nih.gov/23275831 DMGTAWC DI DMGTAWC DMGTAWC DN RKI-1447 DMGTAWC MI TTZQTY2 DMGTAWC MN DMPK messenger RNA (DMPK mRNA) DMGTAWC MT DTT DMGTAWC MA Inhibitor DMGTAWC RN Pyridylthiazole-based ureas as inhibitors of Rho associated protein kinases (ROCK1 and 2). Medchemcomm. 2012 Jun 1;3(6):699-709. DMGTAWC RU https://pubmed.ncbi.nlm.nih.gov/23275831 DMGTAWC DI DMGTAWC DMGTAWC DN RKI-1447 DMGTAWC MI TTWL9TY DMGTAWC MN LIM domain kinase-1 (LIMK-1) DMGTAWC MT DTT DMGTAWC MA Inhibitor DMGTAWC RN Pyridylthiazole-based ureas as inhibitors of Rho associated protein kinases (ROCK1 and 2). Medchemcomm. 2012 Jun 1;3(6):699-709. DMGTAWC RU https://pubmed.ncbi.nlm.nih.gov/23275831 DMGTAWC DI DMGTAWC DMGTAWC DN RKI-1447 DMGTAWC MI TT18ETS DMGTAWC MN Myosin light kinase (MYLK) DMGTAWC MT DTT DMGTAWC MA Inhibitor DMGTAWC RN Pyridylthiazole-based ureas as inhibitors of Rho associated protein kinases (ROCK1 and 2). Medchemcomm. 2012 Jun 1;3(6):699-709. DMGTAWC RU https://pubmed.ncbi.nlm.nih.gov/23275831 DMGTAWC DI DMGTAWC DMGTAWC DN RKI-1447 DMGTAWC MI TTFN95D DMGTAWC MN PAK-1 protein kinase (PAK1) DMGTAWC MT DTT DMGTAWC MA Inhibitor DMGTAWC RN Pyridylthiazole-based ureas as inhibitors of Rho associated protein kinases (ROCK1 and 2). Medchemcomm. 2012 Jun 1;3(6):699-709. DMGTAWC RU https://pubmed.ncbi.nlm.nih.gov/23275831 DMGTAWC DI DMGTAWC DMGTAWC DN RKI-1447 DMGTAWC MI TTSL41O DMGTAWC MN Protein kinase N1 (PKN1) DMGTAWC MT DTT DMGTAWC MA Inhibitor DMGTAWC RN Pyridylthiazole-based ureas as inhibitors of Rho associated protein kinases (ROCK1 and 2). Medchemcomm. 2012 Jun 1;3(6):699-709. DMGTAWC RU https://pubmed.ncbi.nlm.nih.gov/23275831 DMGTAWC DI DMGTAWC DMGTAWC DN RKI-1447 DMGTAWC MI TTZN7RP DMGTAWC MN Rho-associated protein kinase 1 (ROCK1) DMGTAWC MT DTT DMGTAWC MA Inhibitor DMGTAWC RN Pyridylthiazole-based ureas as inhibitors of Rho associated protein kinases (ROCK1 and 2). Medchemcomm. 2012 Jun 1;3(6):699-709. DMGTAWC RU https://pubmed.ncbi.nlm.nih.gov/23275831 DMGTAWC DI DMGTAWC DMGTAWC DN RKI-1447 DMGTAWC MI TTGWKQJ DMGTAWC MN Rho-associated protein kinase 2 (ROCK2) DMGTAWC MT DTT DMGTAWC MA Inhibitor DMGTAWC RN Pyridylthiazole-based ureas as inhibitors of Rho associated protein kinases (ROCK1 and 2). Medchemcomm. 2012 Jun 1;3(6):699-709. DMGTAWC RU https://pubmed.ncbi.nlm.nih.gov/23275831 DMGEDQJ DI DMGEDQJ DMGEDQJ DN R-L3 DMGEDQJ MI TT846HF DMGEDQJ MN Voltage-gated potassium channel Kv7.1 (KCNQ1) DMGEDQJ MT DTT DMGEDQJ MA Activator DMGEDQJ RN A novel benzodiazepine that activates cardiac slow delayed rectifier K+ currents. Mol Pharmacol. 1998 Jul;54(1):220-30. DMGEDQJ RU https://pubmed.ncbi.nlm.nih.gov/9658209 DM87Z3Y DI DM87Z3Y DM87Z3Y DN RM-6427 DM87Z3Y MI TTGKNB4 DM87Z3Y MN Epidermal growth factor receptor (EGFR) DM87Z3Y MT DTT DM87Z3Y MA Inhibitor DM87Z3Y RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1797). DM87Z3Y RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1797 DMJU5A9 DI DMJU5A9 DMJU5A9 DN RM65 DMJU5A9 MI TTVOJAI DMJU5A9 MN Protein arginine methyltransferase 1 (PRMT1) DMJU5A9 MT DTT DMJU5A9 MA Inhibitor DMJU5A9 RN A novel arginine methyltransferase inhibitor with cellular activity. Bioorg Med Chem Lett. 2007 Aug 1;17(15):4150-3. DMJU5A9 RU https://pubmed.ncbi.nlm.nih.gov/17570663 DMA3ZXM DI DMA3ZXM DMA3ZXM DN RN1734 DMA3ZXM MI TTKP2SU DMA3ZXM MN Transient receptor potential cation channel V4 (TRPV4) DMA3ZXM MT DTT DMA3ZXM MA Blocker (channel blocker) DMA3ZXM RN Identification and characterization of novel TRPV4 modulators. Biochem Biophys Res Commun. 2009 Nov 20;389(3):490-4. DMA3ZXM RU https://pubmed.ncbi.nlm.nih.gov/19737537 DMIPZTM DI DMIPZTM DMIPZTM DN RN1747 DMIPZTM MI TTKP2SU DMIPZTM MN Transient receptor potential cation channel V4 (TRPV4) DMIPZTM MT DTT DMIPZTM MA Activator DMIPZTM RN Identification and characterization of novel TRPV4 modulators. Biochem Biophys Res Commun. 2009 Nov 20;389(3):490-4. DMIPZTM RU https://pubmed.ncbi.nlm.nih.gov/19737537 DML7SQH DI DML7SQH DML7SQH DN RN486 DML7SQH MI TT8K4DE DML7SQH MN STE20-related serine/threonine-protein kinase (SLK) DML7SQH MT DTT DML7SQH MA Inhibitor DML7SQH RN RN486, a selective Bruton's tyrosine kinase inhibitor, abrogates immune hypersensitivity responses and arthritis in rodents. J Pharmacol Exp Ther. 2012 Apr;341(1):90-103. DML7SQH RU https://pubmed.ncbi.nlm.nih.gov/22228807 DML7SQH DI DML7SQH DML7SQH DN RN486 DML7SQH MI TTGM6VW DML7SQH MN Tyrosine-protein kinase BTK (ATK) DML7SQH MT DTT DML7SQH MA Inhibitor DML7SQH RN RN486, a selective Bruton's tyrosine kinase inhibitor, abrogates immune hypersensitivity responses and arthritis in rodents. J Pharmacol Exp Ther. 2012 Apr;341(1):90-103. DML7SQH RU https://pubmed.ncbi.nlm.nih.gov/22228807 DM2N3BA DI DM2N3BA DM2N3BA DN R-N6-(phenylisopropyl)adenosine DM2N3BA MI TTK25J1 DM2N3BA MN Adenosine A1 receptor (ADORA1) DM2N3BA MT DTT DM2N3BA MA Inhibitor DM2N3BA RN Comparative pharmacology of human adenosine receptor subtypes - characterization of stably transfected receptors in CHO cells. Naunyn Schmiedebergs Arch Pharmacol. 1998 Jan;357(1):1-9. DM2N3BA RU https://pubmed.ncbi.nlm.nih.gov/9459566 DM2N3BA DI DM2N3BA DM2N3BA DN R-N6-(phenylisopropyl)adenosine DM2N3BA MI TTM2AOE DM2N3BA MN Adenosine A2a receptor (ADORA2A) DM2N3BA MT DTT DM2N3BA MA Inhibitor DM2N3BA RN Structure-activity relationships of 2,N(6),5'-substituted adenosine derivatives with potent activity at the A2B adenosine receptor. J Med Chem. 2007 Apr 19;50(8):1810-27. DM2N3BA RU https://pubmed.ncbi.nlm.nih.gov/17378544 DM2N3BA DI DM2N3BA DM2N3BA DN R-N6-(phenylisopropyl)adenosine DM2N3BA MI TTNE7KG DM2N3BA MN Adenosine A2b receptor (ADORA2B) DM2N3BA MT DTT DM2N3BA MA Agonist DM2N3BA RN Adenosine receptor activation in human fibroblasts: nucleoside agonists and antagonists. Can J Physiol Pharmacol. 1980 Jun;58(6):673-91. DM2N3BA RU https://pubmed.ncbi.nlm.nih.gov/6253037 DM2N3BA DI DM2N3BA DM2N3BA DN R-N6-(phenylisopropyl)adenosine DM2N3BA MI TTJFY5U DM2N3BA MN Adenosine A3 receptor (ADORA3) DM2N3BA MT DTT DM2N3BA MA Inhibitor DM2N3BA RN Structure-activity relationships for 2-substituted adenosines at A1 and A2 adenosine receptors. Pharmacology. 1993;46(2):91-100. DM2N3BA RU https://pubmed.ncbi.nlm.nih.gov/8441759 DMGV4DS DI DMGV4DS DMGV4DS DN R-norduloxetine DMGV4DS MI TTVBI8W DMGV4DS MN Dopamine transporter (DAT) DMGV4DS MT DTT DMGV4DS MA Inhibitor DMGV4DS RN Inhibition of serotonin and norepinephrine reuptake and inhibition of phosphodiesterase by multi-target inhibitors as potential agents for depression. Bioorg Med Chem. 2009 Oct 1;17(19):6890-7. DMGV4DS RU https://pubmed.ncbi.nlm.nih.gov/19740668 DMGV4DS DI DMGV4DS DMGV4DS DN R-norduloxetine DMGV4DS MI TTAWNKZ DMGV4DS MN Norepinephrine transporter (NET) DMGV4DS MT DTT DMGV4DS MA Inhibitor DMGV4DS RN Inhibition of serotonin and norepinephrine reuptake and inhibition of phosphodiesterase by multi-target inhibitors as potential agents for depression. Bioorg Med Chem. 2009 Oct 1;17(19):6890-7. DMGV4DS RU https://pubmed.ncbi.nlm.nih.gov/19740668 DMGV4DS DI DMGV4DS DMGV4DS DN R-norduloxetine DMGV4DS MI TT3ROYC DMGV4DS MN Serotonin transporter (SERT) DMGV4DS MT DTT DMGV4DS MA Inhibitor DMGV4DS RN Inhibition of serotonin and norepinephrine reuptake and inhibition of phosphodiesterase by multi-target inhibitors as potential agents for depression. Bioorg Med Chem. 2009 Oct 1;17(19):6890-7. DMGV4DS RU https://pubmed.ncbi.nlm.nih.gov/19740668 DMXT34V DI DMXT34V DMXT34V DN Ro 10-4548 DMXT34V MI TTE0A2F DMXT34V MN Dopamine D4 receptor (D4R) DMXT34V MT DTT DMXT34V MA Antagonist DMXT34V RN Certain 1,4-disubstituted aromatic piperidines and piperazines with extreme selectivity for the dopamine D4 receptor interact with a common recepto... Mol Pharmacol. 2004 Dec;66(6):1491-9. DMXT34V RU https://pubmed.ncbi.nlm.nih.gov/15448188 DMMO6PH DI DMMO6PH DMMO6PH DN RO 116 1148 DMMO6PH MI TT07C3Y DMMO6PH MN 5-HT 4 receptor (HTR4) DMMO6PH MT DTT DMMO6PH MA Antagonist DMMO6PH RN A 5-HT4 receptor transmembrane network implicated in the activity of inverse agonists but not agonists. J Biol Chem. 2002 Jul 12;277(28):25502-11. DMMO6PH RU https://pubmed.ncbi.nlm.nih.gov/11976337 DM3FYUM DI DM3FYUM DM3FYUM DN RO 244383 DM3FYUM MI TTJP4SM DM3FYUM MN Bacterial Penicillin binding protein (Bact PBP) DM3FYUM MT DTT DM3FYUM MA Modulator DM3FYUM RN Mechanisms of resistance to cephalosporin antibiotics.Drugs.1987;34 Suppl 2:64-88. DM3FYUM RU https://www.ncbi.nlm.nih.gov/pubmed/3319506 DMDC4HY DI DMDC4HY DMDC4HY DN Ro 28-2653 DMDC4HY MI TT6X50U DMDC4HY MN Matrix metalloproteinase-9 (MMP-9) DMDC4HY MT DTT DMDC4HY MA Inhibitor DMDC4HY RN The new synthetic matrix metalloproteinase inhibitor (Roche 28-2653) reduces tumor growth and prolongs survival in a prostate cancer standard rat model. Oncogene. 2002 Mar 27;21(13):2089-96. DMDC4HY RU https://pubmed.ncbi.nlm.nih.gov/11960381 DMU2EKN DI DMU2EKN DMU2EKN DN Ro 40-6055 DMU2EKN MI TTW38KT DMU2EKN MN Retinoic acid receptor alpha (RARA) DMU2EKN MT DTT DMU2EKN MA Agonist DMU2EKN RN Selective high affinity retinoic acid receptor alpha or beta-gamma ligands. Mol Pharmacol. 1991 Oct;40(4):556-62. DMU2EKN RU https://pubmed.ncbi.nlm.nih.gov/1656191 DMSJLWP DI DMSJLWP DMSJLWP DN Ro 41-5253 DMSJLWP MI TTW38KT DMSJLWP MN Retinoic acid receptor alpha (RARA) DMSJLWP MT DTT DMSJLWP MA Antagonist DMSJLWP RN A retinoic acid receptor alpha antagonist selectively counteracts retinoic acid effects. Proc Natl Acad Sci U S A. 1992 Aug 1;89(15):7129-33. DMSJLWP RU https://pubmed.ncbi.nlm.nih.gov/1323127 DMXMSYB DI DMXMSYB DMXMSYB DN Ro 46-8443 DMXMSYB MI TT3ZTGU DMXMSYB MN Endothelin B receptor (EDNRB) DMXMSYB MT DTT DMXMSYB MA Antagonist DMXMSYB RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 220). DMXMSYB RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=220 DMTQP0K DI DMTQP0K DMTQP0K DN Ro 5-4864 DMTQP0K MI TT9SL3Q DMTQP0K MN Polypeptide deformylase (PDF) DMTQP0K MT DTT DMTQP0K MA Inhibitor DMTQP0K RN Emerging drugs for bacterial urinary tract infections. Expert Opin Emerg Drugs. 2005 May;10(2):275-98. DMTQP0K RU https://pubmed.ncbi.nlm.nih.gov/15934867 DMTQP0K DI DMTQP0K DMTQP0K DN Ro 5-4864 DMTQP0K MI TTPTXIN DMTQP0K MN Translocator protein (TSPO) DMTQP0K MT DTT DMTQP0K MA Binder DMTQP0K RN Specific ligands of the peripheral benzodiazepine receptor induce apoptosis and cell cycle arrest in human colorectal cancer cells. Br J Cancer. 2001 Nov 30;85(11):1771-80. DMTQP0K RU https://pubmed.ncbi.nlm.nih.gov/11742501 DMYVQF5 DI DMYVQF5 DMYVQF5 DN Ro 63-1908 DMYVQF5 MI TTN9D8E DMYVQF5 MN Glutamate receptor ionotropic NMDA 2B (NMDAR2B) DMYVQF5 MT DTT DMYVQF5 MA Antagonist DMYVQF5 RN Pharmacological characterization of Ro 63-1908 (1-[2-(4-hydroxy-phenoxy)-ethyl]-4-(4-methyl-benzyl)-piperidin-4-ol), a novel subtype-selective N-methyl-D-aspartate antagonist. J Pharmacol Exp Ther. 2002 Sep;302(3):940-8. DMYVQF5 RU https://pubmed.ncbi.nlm.nih.gov/12183650 DM0AC84 DI DM0AC84 DM0AC84 DN Ro01-6128 DM0AC84 MI TTVBPDM DM0AC84 MN Metabotropic glutamate receptor 1 (mGluR1) DM0AC84 MT DTT DM0AC84 MA Modulator (allosteric modulator) DM0AC84 RN Positive allosteric modulators of metabotropic glutamate 1 receptor: characterization, mechanism of action, and binding site. Proc Natl Acad Sci U S A. 2001 Nov 6;98(23):13402-7. DM0AC84 RU https://pubmed.ncbi.nlm.nih.gov/11606768 DM6H8JM DI DM6H8JM DM6H8JM DN Ro-04-6790 DM6H8JM MI TTJS8PY DM6H8JM MN 5-HT 6 receptor (HTR6) DM6H8JM MT DTT DM6H8JM MA Inhibitor DM6H8JM RN Indene-based scaffolds. 2. An indole-indene switch: discovery of novel indenylsulfonamides as 5-HT6 serotonin receptor agonists. J Med Chem. 2009 Feb 12;52(3):675-87. DM6H8JM RU https://pubmed.ncbi.nlm.nih.gov/19159187 DMLVERQ DI DMLVERQ DMLVERQ DN Ro-0505124 DMLVERQ MI TT0PG8F DMLVERQ MN Cyclin-dependent kinase 4 (CDK4) DMLVERQ MT DTT DMLVERQ MA Inhibitor DMLVERQ RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1976). DMLVERQ RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1976 DMLVERQ DI DMLVERQ DMLVERQ DN Ro-0505124 DMLVERQ MI TTX5KEQ DMLVERQ MN Fused homolog (STK36) DMLVERQ MT DTT DMLVERQ MA Inhibitor DMLVERQ RN Inhibition of S/G2 phase CDK4 reduces mitotic fidelity. J Biol Chem. 2006 Apr 14;281(15):9987-95. DMLVERQ RU https://pubmed.ncbi.nlm.nih.gov/16476733 DM78B4A DI DM78B4A DM78B4A DN RO-054520 DM78B4A MI TT1MPAY DM78B4A MN GABA(A) receptor alpha-1 (GABRA1) DM78B4A MT DTT DM78B4A MA Inhibitor DM78B4A RN Methods for drug discovery: development of potent, selective, orally effective cholecystokinin antagonists. J Med Chem. 1988 Dec;31(12):2235-46. DM78B4A RU https://pubmed.ncbi.nlm.nih.gov/2848124 DM78B4A DI DM78B4A DM78B4A DN RO-054520 DM78B4A MI TTNJYV2 DM78B4A MN Gamma-aminobutyric acid receptor (GAR) DM78B4A MT DTT DM78B4A MA Inhibitor DM78B4A RN Methods for drug discovery: development of potent, selective, orally effective cholecystokinin antagonists. J Med Chem. 1988 Dec;31(12):2235-46. DM78B4A RU https://pubmed.ncbi.nlm.nih.gov/2848124 DMZLUAK DI DMZLUAK DMZLUAK DN Ro0711401 DMZLUAK MI TTVBPDM DMZLUAK MN Metabotropic glutamate receptor 1 (mGluR1) DMZLUAK MT DTT DMZLUAK MA Modulator (allosteric modulator) DMZLUAK RN Fluorinated 9H-xanthene-9-carboxylic acid oxazol-2-yl-amides as potent, orally available mGlu1 receptor enhancers. Bioorg Med Chem Lett. 2009 Mar 15;19(6):1666-9. DMZLUAK RU https://pubmed.ncbi.nlm.nih.gov/19233648 DM2DXHO DI DM2DXHO DM2DXHO DN Ro092210 DM2DXHO MI TTQBCEJ DM2DXHO MN MAPK/ERK kinase kinase 1 (MAP3K1) DM2DXHO MT DTT DM2DXHO MA Inhibitor DM2DXHO RN Pharmacological inhibitors of MAPK pathways. Trends Pharmacol Sci. 2002 Jan;23(1):40-5. DM2DXHO RU https://pubmed.ncbi.nlm.nih.gov/11804650 DM2DXHO DI DM2DXHO DM2DXHO DN Ro092210 DM2DXHO MI TTK1N5G DM2DXHO MN MAPK/ERK kinase kinase 2 (MAP3K2) DM2DXHO MT DTT DM2DXHO MA Inhibitor DM2DXHO RN Pharmacological inhibitors of MAPK pathways. Trends Pharmacol Sci. 2002 Jan;23(1):40-5. DM2DXHO RU https://pubmed.ncbi.nlm.nih.gov/11804650 DMOQ0CE DI DMOQ0CE DMOQ0CE DN Ro-11-04253 DMOQ0CE MI TTNGILX DMOQ0CE MN Adrenergic receptor alpha-1A (ADRA1A) DMOQ0CE MT DTT DMOQ0CE MA Inhibitor DMOQ0CE RN Pharmacophore identification of alpha(1A)-adrenoceptor antagonists. Bioorg Med Chem Lett. 2005 Feb 1;15(3):657-64. DMOQ0CE RU https://pubmed.ncbi.nlm.nih.gov/15664832 DMAOI51 DI DMAOI51 DMAOI51 DN RO1138452 DMAOI51 MI TTOFYT1 DMAOI51 MN Prostacyclin receptor (PTGIR) DMAOI51 MT DTT DMAOI51 MA Antagonist DMAOI51 RN RO1138452 and RO3244794: characterization of structurally distinct, potent and selective IP (prostacyclin) receptor antagonists. Br J Pharmacol. 2006 Feb;147(3):335-45. DMAOI51 RU https://pubmed.ncbi.nlm.nih.gov/16331286 DMFTW0U DI DMFTW0U DMFTW0U DN RO116-4875/608 DMFTW0U MI TTU3Y87 DMFTW0U MN CCR3 messenger RNA (CCR3 mRNA) DMFTW0U MT DTT DMFTW0U MA Antagonist DMFTW0U RN Responses of leukocytes to chemokines in whole blood and their antagonism by novel CC-chemokine receptor 3 antagonists. Am J Respir Crit Care Med. 2002 Jun 15;165(12):1602-9. DMFTW0U RU https://pubmed.ncbi.nlm.nih.gov/12070060 DM6XM1D DI DM6XM1D DM6XM1D DN RO116-9132/238 DM6XM1D MI TTU3Y87 DM6XM1D MN CCR3 messenger RNA (CCR3 mRNA) DM6XM1D MT DTT DM6XM1D MA Antagonist DM6XM1D RN Responses of leukocytes to chemokines in whole blood and their antagonism by novel CC-chemokine receptor 3 antagonists. Am J Respir Crit Care Med. 2002 Jun 15;165(12):1602-9. DM6XM1D RU https://pubmed.ncbi.nlm.nih.gov/12070060 DM0ACKJ DI DM0ACKJ DM0ACKJ DN RO-145974 DM0ACKJ MI TT1MPAY DM0ACKJ MN GABA(A) receptor alpha-1 (GABRA1) DM0ACKJ MT DTT DM0ACKJ MA Inhibitor DM0ACKJ RN Synthesis and evaluation of imidazo[1,5-a][1,4]benzodiazepine esters with high affinities and selectivities at "diazepam-insensitive" benzodiazepin... J Med Chem. 1993 Apr 16;36(8):1001-6. DM0ACKJ RU https://pubmed.ncbi.nlm.nih.gov/8386769 DM0ACKJ DI DM0ACKJ DM0ACKJ DN RO-145974 DM0ACKJ MI TTZA1NY DM0ACKJ MN GABA(A) receptor beta-2 (GABRB2) DM0ACKJ MT DTT DM0ACKJ MA Inhibitor DM0ACKJ RN Synthesis and evaluation of imidazo[1,5-a][1,4]benzodiazepine esters with high affinities and selectivities at "diazepam-insensitive" benzodiazepin... J Med Chem. 1993 Apr 16;36(8):1001-6. DM0ACKJ RU https://pubmed.ncbi.nlm.nih.gov/8386769 DM0ACKJ DI DM0ACKJ DM0ACKJ DN RO-145974 DM0ACKJ MI TT06RH5 DM0ACKJ MN GABA(A) receptor gamma-2 (GABRG2) DM0ACKJ MT DTT DM0ACKJ MA Inhibitor DM0ACKJ RN Synthesis and evaluation of imidazo[1,5-a][1,4]benzodiazepine esters with high affinities and selectivities at "diazepam-insensitive" benzodiazepin... J Med Chem. 1993 Apr 16;36(8):1001-6. DM0ACKJ RU https://pubmed.ncbi.nlm.nih.gov/8386769 DM0ACKJ DI DM0ACKJ DM0ACKJ DN RO-145974 DM0ACKJ MI TTNJYV2 DM0ACKJ MN Gamma-aminobutyric acid receptor (GAR) DM0ACKJ MT DTT DM0ACKJ MA Inhibitor DM0ACKJ RN Synthesis and evaluation of imidazo[1,5-a][1,4]benzodiazepine esters with high affinities and selectivities at "diazepam-insensitive" benzodiazepin... J Med Chem. 1993 Apr 16;36(8):1001-6. DM0ACKJ RU https://pubmed.ncbi.nlm.nih.gov/8386769 DMAJ6BW DI DMAJ6BW DMAJ6BW DN RO-145975 DMAJ6BW MI TT1MPAY DMAJ6BW MN GABA(A) receptor alpha-1 (GABRA1) DMAJ6BW MT DTT DMAJ6BW MA Inhibitor DMAJ6BW RN Synthesis and evaluation of imidazo[1,5-a][1,4]benzodiazepine esters with high affinities and selectivities at "diazepam-insensitive" benzodiazepin... J Med Chem. 1993 Apr 16;36(8):1001-6. DMAJ6BW RU https://pubmed.ncbi.nlm.nih.gov/8386769 DMAJ6BW DI DMAJ6BW DMAJ6BW DN RO-145975 DMAJ6BW MI TTZA1NY DMAJ6BW MN GABA(A) receptor beta-2 (GABRB2) DMAJ6BW MT DTT DMAJ6BW MA Inhibitor DMAJ6BW RN Synthesis and evaluation of imidazo[1,5-a][1,4]benzodiazepine esters with high affinities and selectivities at "diazepam-insensitive" benzodiazepin... J Med Chem. 1993 Apr 16;36(8):1001-6. DMAJ6BW RU https://pubmed.ncbi.nlm.nih.gov/8386769 DMAJ6BW DI DMAJ6BW DMAJ6BW DN RO-145975 DMAJ6BW MI TT06RH5 DMAJ6BW MN GABA(A) receptor gamma-2 (GABRG2) DMAJ6BW MT DTT DMAJ6BW MA Inhibitor DMAJ6BW RN Synthesis and evaluation of imidazo[1,5-a][1,4]benzodiazepine esters with high affinities and selectivities at "diazepam-insensitive" benzodiazepin... J Med Chem. 1993 Apr 16;36(8):1001-6. DMAJ6BW RU https://pubmed.ncbi.nlm.nih.gov/8386769 DMAJ6BW DI DMAJ6BW DMAJ6BW DN RO-145975 DMAJ6BW MI TTNJYV2 DMAJ6BW MN Gamma-aminobutyric acid receptor (GAR) DMAJ6BW MT DTT DMAJ6BW MA Inhibitor DMAJ6BW RN Synthesis and evaluation of imidazo[1,5-a][1,4]benzodiazepine esters with high affinities and selectivities at "diazepam-insensitive" benzodiazepin... J Med Chem. 1993 Apr 16;36(8):1001-6. DMAJ6BW RU https://pubmed.ncbi.nlm.nih.gov/8386769 DMX4B36 DI DMX4B36 DMX4B36 DN RO-147437 DMX4B36 MI TT1MPAY DMX4B36 MN GABA(A) receptor alpha-1 (GABRA1) DMX4B36 MT DTT DMX4B36 MA Inhibitor DMX4B36 RN Synthesis and evaluation of imidazo[1,5-a][1,4]benzodiazepine esters with high affinities and selectivities at "diazepam-insensitive" benzodiazepin... J Med Chem. 1993 Apr 16;36(8):1001-6. DMX4B36 RU https://pubmed.ncbi.nlm.nih.gov/8386769 DMX4B36 DI DMX4B36 DMX4B36 DN RO-147437 DMX4B36 MI TTZA1NY DMX4B36 MN GABA(A) receptor beta-2 (GABRB2) DMX4B36 MT DTT DMX4B36 MA Inhibitor DMX4B36 RN Synthesis and evaluation of imidazo[1,5-a][1,4]benzodiazepine esters with high affinities and selectivities at "diazepam-insensitive" benzodiazepin... J Med Chem. 1993 Apr 16;36(8):1001-6. DMX4B36 RU https://pubmed.ncbi.nlm.nih.gov/8386769 DMX4B36 DI DMX4B36 DMX4B36 DN RO-147437 DMX4B36 MI TT06RH5 DMX4B36 MN GABA(A) receptor gamma-2 (GABRG2) DMX4B36 MT DTT DMX4B36 MA Inhibitor DMX4B36 RN Synthesis and evaluation of imidazo[1,5-a][1,4]benzodiazepine esters with high affinities and selectivities at "diazepam-insensitive" benzodiazepin... J Med Chem. 1993 Apr 16;36(8):1001-6. DMX4B36 RU https://pubmed.ncbi.nlm.nih.gov/8386769 DMX4B36 DI DMX4B36 DMX4B36 DN RO-147437 DMX4B36 MI TTNJYV2 DMX4B36 MN Gamma-aminobutyric acid receptor (GAR) DMX4B36 MT DTT DMX4B36 MA Inhibitor DMX4B36 RN Synthesis and evaluation of imidazo[1,5-a][1,4]benzodiazepine esters with high affinities and selectivities at "diazepam-insensitive" benzodiazepin... J Med Chem. 1993 Apr 16;36(8):1001-6. DMX4B36 RU https://pubmed.ncbi.nlm.nih.gov/8386769 DM4NW3U DI DM4NW3U DM4NW3U DN Ro-15-3505 DM4NW3U MI TT1MPAY DM4NW3U MN GABA(A) receptor alpha-1 (GABRA1) DM4NW3U MT DTT DM4NW3U MA Inhibitor DM4NW3U RN Synthesis and evaluation of imidazo[1,5-a][1,4]benzodiazepine esters with high affinities and selectivities at "diazepam-insensitive" benzodiazepin... J Med Chem. 1993 Apr 16;36(8):1001-6. DM4NW3U RU https://pubmed.ncbi.nlm.nih.gov/8386769 DM4NW3U DI DM4NW3U DM4NW3U DN Ro-15-3505 DM4NW3U MI TTBMV1G DM4NW3U MN GABA(A) receptor alpha-2 (GABRA2) DM4NW3U MT DTT DM4NW3U MA Inhibitor DM4NW3U RN The GABA(A) receptor as a target for photochromic molecules. Bioorg Med Chem. 2010 Nov 15;18(22):7731-8. DM4NW3U RU https://pubmed.ncbi.nlm.nih.gov/20646926 DM4NW3U DI DM4NW3U DM4NW3U DN Ro-15-3505 DM4NW3U MI TT37EDJ DM4NW3U MN GABA(A) receptor alpha-3 (GABRA3) DM4NW3U MT DTT DM4NW3U MA Inhibitor DM4NW3U RN The GABA(A) receptor as a target for photochromic molecules. Bioorg Med Chem. 2010 Nov 15;18(22):7731-8. DM4NW3U RU https://pubmed.ncbi.nlm.nih.gov/20646926 DM4NW3U DI DM4NW3U DM4NW3U DN Ro-15-3505 DM4NW3U MI TTNZPQ1 DM4NW3U MN GABA(A) receptor alpha-5 (GABRA5) DM4NW3U MT DTT DM4NW3U MA Inhibitor DM4NW3U RN The GABA(A) receptor as a target for photochromic molecules. Bioorg Med Chem. 2010 Nov 15;18(22):7731-8. DM4NW3U RU https://pubmed.ncbi.nlm.nih.gov/20646926 DM4NW3U DI DM4NW3U DM4NW3U DN Ro-15-3505 DM4NW3U MI TTZA1NY DM4NW3U MN GABA(A) receptor beta-2 (GABRB2) DM4NW3U MT DTT DM4NW3U MA Inhibitor DM4NW3U RN Synthesis and evaluation of imidazo[1,5-a][1,4]benzodiazepine esters with high affinities and selectivities at "diazepam-insensitive" benzodiazepin... J Med Chem. 1993 Apr 16;36(8):1001-6. DM4NW3U RU https://pubmed.ncbi.nlm.nih.gov/8386769 DM4NW3U DI DM4NW3U DM4NW3U DN Ro-15-3505 DM4NW3U MI TT06RH5 DM4NW3U MN GABA(A) receptor gamma-2 (GABRG2) DM4NW3U MT DTT DM4NW3U MA Inhibitor DM4NW3U RN Synthesis and evaluation of imidazo[1,5-a][1,4]benzodiazepine esters with high affinities and selectivities at "diazepam-insensitive" benzodiazepin... J Med Chem. 1993 Apr 16;36(8):1001-6. DM4NW3U RU https://pubmed.ncbi.nlm.nih.gov/8386769 DM4NW3U DI DM4NW3U DM4NW3U DN Ro-15-3505 DM4NW3U MI TTEX6LM DM4NW3U MN GABA(A) receptor gamma-3 (GABRG3) DM4NW3U MT DTT DM4NW3U MA Modulator DM4NW3U RN Molecular structure and stereoelectronic properties of sarmazenil--a weak inverse agonist at the omega modulatory sites (benzodiazepine receptors):... Bioorg Med Chem. 1998 Oct;6(10):1745-57. DM4NW3U RU https://www.ncbi.nlm.nih.gov/pubmed/9839004 DM4NW3U DI DM4NW3U DM4NW3U DN Ro-15-3505 DM4NW3U MI TTNJYV2 DM4NW3U MN Gamma-aminobutyric acid receptor (GAR) DM4NW3U MT DTT DM4NW3U MA Inhibitor DM4NW3U RN The GABA(A) receptor as a target for photochromic molecules. Bioorg Med Chem. 2010 Nov 15;18(22):7731-8. DM4NW3U RU https://pubmed.ncbi.nlm.nih.gov/20646926 DM8C2Z0 DI DM8C2Z0 DM8C2Z0 DN RO-194603 DM8C2Z0 MI TT1MPAY DM8C2Z0 MN GABA(A) receptor alpha-1 (GABRA1) DM8C2Z0 MT DTT DM8C2Z0 MA Inhibitor DM8C2Z0 RN Synthesis and evaluation of imidazo[1,5-a][1,4]benzodiazepine esters with high affinities and selectivities at "diazepam-insensitive" benzodiazepin... J Med Chem. 1993 Apr 16;36(8):1001-6. DM8C2Z0 RU https://pubmed.ncbi.nlm.nih.gov/8386769 DM8C2Z0 DI DM8C2Z0 DM8C2Z0 DN RO-194603 DM8C2Z0 MI TTZA1NY DM8C2Z0 MN GABA(A) receptor beta-2 (GABRB2) DM8C2Z0 MT DTT DM8C2Z0 MA Inhibitor DM8C2Z0 RN Synthesis and evaluation of imidazo[1,5-a][1,4]benzodiazepine esters with high affinities and selectivities at "diazepam-insensitive" benzodiazepin... J Med Chem. 1993 Apr 16;36(8):1001-6. DM8C2Z0 RU https://pubmed.ncbi.nlm.nih.gov/8386769 DM8C2Z0 DI DM8C2Z0 DM8C2Z0 DN RO-194603 DM8C2Z0 MI TT06RH5 DM8C2Z0 MN GABA(A) receptor gamma-2 (GABRG2) DM8C2Z0 MT DTT DM8C2Z0 MA Inhibitor DM8C2Z0 RN Synthesis and evaluation of imidazo[1,5-a][1,4]benzodiazepine esters with high affinities and selectivities at "diazepam-insensitive" benzodiazepin... J Med Chem. 1993 Apr 16;36(8):1001-6. DM8C2Z0 RU https://pubmed.ncbi.nlm.nih.gov/8386769 DM8C2Z0 DI DM8C2Z0 DM8C2Z0 DN RO-194603 DM8C2Z0 MI TTNJYV2 DM8C2Z0 MN Gamma-aminobutyric acid receptor (GAR) DM8C2Z0 MT DTT DM8C2Z0 MA Inhibitor DM8C2Z0 RN Synthesis and evaluation of imidazo[1,5-a][1,4]benzodiazepine esters with high affinities and selectivities at "diazepam-insensitive" benzodiazepin... J Med Chem. 1993 Apr 16;36(8):1001-6. DM8C2Z0 RU https://pubmed.ncbi.nlm.nih.gov/8386769 DMOE0JX DI DMOE0JX DMOE0JX DN Ro-21-7767 DMOE0JX MI TTZFYLI DMOE0JX MN Dopamine D1 receptor (D1R) DMOE0JX MT DTT DMOE0JX MA Inhibitor DMOE0JX RN Evaluation of cis- and trans-9- and 11-hydroxy-5,6,6a,7,8,12b-hexahydrobenzo[a]phenanthridines as structurally rigid, selective D1 dopamine recepto... J Med Chem. 1995 Jan 20;38(2):318-27. DMOE0JX RU https://pubmed.ncbi.nlm.nih.gov/7830274 DMOE0JX DI DMOE0JX DMOE0JX DN Ro-21-7767 DMOE0JX MI TTEX248 DMOE0JX MN Dopamine D2 receptor (D2R) DMOE0JX MT DTT DMOE0JX MA Inhibitor DMOE0JX RN Evaluation of cis- and trans-9- and 11-hydroxy-5,6,6a,7,8,12b-hexahydrobenzo[a]phenanthridines as structurally rigid, selective D1 dopamine recepto... J Med Chem. 1995 Jan 20;38(2):318-27. DMOE0JX RU https://pubmed.ncbi.nlm.nih.gov/7830274 DMGL7TM DI DMGL7TM DMGL7TM DN Ro26-4550 DMGL7TM MI TTAJU0S DMGL7TM MN Interleukin 2 receptor (IL2R) DMGL7TM MT DTT DMGL7TM MA Antagonist DMGL7TM RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2297). DMGL7TM RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2297 DMRYNJE DI DMRYNJE DMRYNJE DN RO3 DMRYNJE MI TT2THBD DMRYNJE MN P2X purinoceptor 3 (P2RX3) DMRYNJE MT DTT DMRYNJE MA Antagonist DMRYNJE RN Purinoceptors as therapeutic targets for lower urinary tract dysfunction. Br J Pharmacol. 2006 Feb;147 Suppl 2:S132-43. DMRYNJE RU https://pubmed.ncbi.nlm.nih.gov/16465177 DMAGLPW DI DMAGLPW DMAGLPW DN RO-316233 DMAGLPW MI TTNAHEX DMAGLPW MN cAMP-dependent protein kinase A type I (PRKAR1A) DMAGLPW MT DTT DMAGLPW MA Inhibitor DMAGLPW RN Inhibitors of protein kinase C. 1. 2,3-Bisarylmaleimides. J Med Chem. 1992 Jan;35(1):177-84. DMAGLPW RU https://pubmed.ncbi.nlm.nih.gov/1732526 DMAGLPW DI DMAGLPW DMAGLPW DN RO-316233 DMAGLPW MI TTTU902 DMAGLPW MN Checkpoint kinase-1 (CHK1) DMAGLPW MT DTT DMAGLPW MA Inhibitor DMAGLPW RN Specificity and mechanism of action of some commonly used protein kinase inhibitors. Biochem J. 2000 Oct 1;351(Pt 1):95-105. DMAGLPW RU https://pubmed.ncbi.nlm.nih.gov/10998351 DMAGLPW DI DMAGLPW DMAGLPW DN RO-316233 DMAGLPW MI TTH6V3D DMAGLPW MN Cyclin-dependent kinase 1 (CDK1) DMAGLPW MT DTT DMAGLPW MA Inhibitor DMAGLPW RN Design of new inhibitors for cdc2 kinase based on a multiple pseudosubstrate structure. Bioorg Med Chem Lett. 1998 May 5;8(9):1019-22. DMAGLPW RU https://pubmed.ncbi.nlm.nih.gov/9871700 DMAGLPW DI DMAGLPW DMAGLPW DN RO-316233 DMAGLPW MI TT4TQBX DMAGLPW MN Extracellular signal-regulated kinase 2 (ERK2) DMAGLPW MT DTT DMAGLPW MA Inhibitor DMAGLPW RN Specificity and mechanism of action of some commonly used protein kinase inhibitors. Biochem J. 2000 Oct 1;351(Pt 1):95-105. DMAGLPW RU https://pubmed.ncbi.nlm.nih.gov/10998351 DMAGLPW DI DMAGLPW DMAGLPW DN RO-316233 DMAGLPW MI TT9P6OW DMAGLPW MN G2/mitotic-specific cyclin B1 (CCNB1) DMAGLPW MT DTT DMAGLPW MA Inhibitor DMAGLPW RN Design of new inhibitors for cdc2 kinase based on a multiple pseudosubstrate structure. Bioorg Med Chem Lett. 1998 May 5;8(9):1019-22. DMAGLPW RU https://pubmed.ncbi.nlm.nih.gov/9871700 DMAGLPW DI DMAGLPW DMAGLPW DN RO-316233 DMAGLPW MI TT860QF DMAGLPW MN LCK tyrosine protein kinase (LCK) DMAGLPW MT DTT DMAGLPW MA Inhibitor DMAGLPW RN Specificity and mechanism of action of some commonly used protein kinase inhibitors. Biochem J. 2000 Oct 1;351(Pt 1):95-105. DMAGLPW RU https://pubmed.ncbi.nlm.nih.gov/10998351 DMAGLPW DI DMAGLPW DMAGLPW DN RO-316233 DMAGLPW MI TTYT93M DMAGLPW MN MAP kinase p38 (MAPK12) DMAGLPW MT DTT DMAGLPW MA Inhibitor DMAGLPW RN Specificity and mechanism of action of some commonly used protein kinase inhibitors. Biochem J. 2000 Oct 1;351(Pt 1):95-105. DMAGLPW RU https://pubmed.ncbi.nlm.nih.gov/10998351 DMAGLPW DI DMAGLPW DMAGLPW DN RO-316233 DMAGLPW MI TTUF2HO DMAGLPW MN NAD-dependent deacetylase sirtuin-1 (SIRT1) DMAGLPW MT DTT DMAGLPW MA Inhibitor DMAGLPW RN Adenosine mimetics as inhibitors of NAD+-dependent histone deacetylases, from kinase to sirtuin inhibition. J Med Chem. 2006 Dec 14;49(25):7307-16. DMAGLPW RU https://pubmed.ncbi.nlm.nih.gov/17149860 DMAGLPW DI DMAGLPW DMAGLPW DN RO-316233 DMAGLPW MI TT57MT2 DMAGLPW MN PKC-epsilon messenger RNA (PRKCE mRNA) DMAGLPW MT DTT DMAGLPW MA Inhibitor DMAGLPW RN Synthesis of anilino-monoindolylmaleimides as potent and selective PKCbeta inhibitors. Bioorg Med Chem Lett. 2004 Oct 18;14(20):5171-4. DMAGLPW RU https://pubmed.ncbi.nlm.nih.gov/15380221 DMAGLPW DI DMAGLPW DMAGLPW DN RO-316233 DMAGLPW MI TTFJ8Q1 DMAGLPW MN Protein kinase C alpha (PRKCA) DMAGLPW MT DTT DMAGLPW MA Inhibitor DMAGLPW RN Inhibitors of protein kinase C. 1. 2,3-Bisarylmaleimides. J Med Chem. 1992 Jan;35(1):177-84. DMAGLPW RU https://pubmed.ncbi.nlm.nih.gov/1732526 DMAGLPW DI DMAGLPW DMAGLPW DN RO-316233 DMAGLPW MI TTYPXQF DMAGLPW MN Protein kinase C beta (PRKCB) DMAGLPW MT DTT DMAGLPW MA Inhibitor DMAGLPW RN Inhibitors of protein kinase C. 1. 2,3-Bisarylmaleimides. J Med Chem. 1992 Jan;35(1):177-84. DMAGLPW RU https://pubmed.ncbi.nlm.nih.gov/1732526 DMAGLPW DI DMAGLPW DMAGLPW DN RO-316233 DMAGLPW MI TT9WJ8U DMAGLPW MN Protein kinase C delta (PRKCD) DMAGLPW MT DTT DMAGLPW MA Inhibitor DMAGLPW RN Inhibitors of protein kinase C. 1. 2,3-Bisarylmaleimides. J Med Chem. 1992 Jan;35(1):177-84. DMAGLPW RU https://pubmed.ncbi.nlm.nih.gov/1732526 DMAGLPW DI DMAGLPW DMAGLPW DN RO-316233 DMAGLPW MI TTBZ7OD DMAGLPW MN Protein kinase C epsilon (PRKCE) DMAGLPW MT DTT DMAGLPW MA Inhibitor DMAGLPW RN Inhibitors of protein kinase C. 1. 2,3-Bisarylmaleimides. J Med Chem. 1992 Jan;35(1):177-84. DMAGLPW RU https://pubmed.ncbi.nlm.nih.gov/1732526 DMAGLPW DI DMAGLPW DMAGLPW DN RO-316233 DMAGLPW MI TTRFOXJ DMAGLPW MN Protein kinase C gamma (PRKCG) DMAGLPW MT DTT DMAGLPW MA Inhibitor DMAGLPW RN Inhibitors of protein kinase C. 1. 2,3-Bisarylmaleimides. J Med Chem. 1992 Jan;35(1):177-84. DMAGLPW RU https://pubmed.ncbi.nlm.nih.gov/1732526 DMAGLPW DI DMAGLPW DMAGLPW DN RO-316233 DMAGLPW MI TT8QL1J DMAGLPW MN Protein kinase C theta (PRKCQ) DMAGLPW MT DTT DMAGLPW MA Inhibitor DMAGLPW RN Inhibitors of protein kinase C. 1. 2,3-Bisarylmaleimides. J Med Chem. 1992 Jan;35(1):177-84. DMAGLPW RU https://pubmed.ncbi.nlm.nih.gov/1732526 DMAGLPW DI DMAGLPW DMAGLPW DN RO-316233 DMAGLPW MI TTUWGRA DMAGLPW MN Protein kinase C zeta (PRKCZ) DMAGLPW MT DTT DMAGLPW MA Inhibitor DMAGLPW RN Inhibitors of protein kinase C. 1. 2,3-Bisarylmaleimides. J Med Chem. 1992 Jan;35(1):177-84. DMAGLPW RU https://pubmed.ncbi.nlm.nih.gov/1732526 DMAGLPW DI DMAGLPW DMAGLPW DN RO-316233 DMAGLPW MI TTWTSCV DMAGLPW MN RAC-alpha serine/threonine-protein kinase (AKT1) DMAGLPW MT DTT DMAGLPW MA Inhibitor DMAGLPW RN Specificity and mechanism of action of some commonly used protein kinase inhibitors. Biochem J. 2000 Oct 1;351(Pt 1):95-105. DMAGLPW RU https://pubmed.ncbi.nlm.nih.gov/10998351 DMAGLPW DI DMAGLPW DMAGLPW DN RO-316233 DMAGLPW MI TTZN7RP DMAGLPW MN Rho-associated protein kinase 1 (ROCK1) DMAGLPW MT DTT DMAGLPW MA Inhibitor DMAGLPW RN Specificity and mechanism of action of some commonly used protein kinase inhibitors. Biochem J. 2000 Oct 1;351(Pt 1):95-105. DMAGLPW RU https://pubmed.ncbi.nlm.nih.gov/10998351 DMAGLPW DI DMAGLPW DMAGLPW DN RO-316233 DMAGLPW MI TTG0U4H DMAGLPW MN Ribosomal protein S6 kinase beta-1 (S6K1) DMAGLPW MT DTT DMAGLPW MA Inhibitor DMAGLPW RN Specificity and mechanism of action of some commonly used protein kinase inhibitors. Biochem J. 2000 Oct 1;351(Pt 1):95-105. DMAGLPW RU https://pubmed.ncbi.nlm.nih.gov/10998351 DMAGLPW DI DMAGLPW DMAGLPW DN RO-316233 DMAGLPW MI TTTV8EJ DMAGLPW MN Serine/threonine-protein kinase Sgk1 (SGK1) DMAGLPW MT DTT DMAGLPW MA Inhibitor DMAGLPW RN Specificity and mechanism of action of some commonly used protein kinase inhibitors. Biochem J. 2000 Oct 1;351(Pt 1):95-105. DMAGLPW RU https://pubmed.ncbi.nlm.nih.gov/10998351 DMAGLPW DI DMAGLPW DMAGLPW DN RO-316233 DMAGLPW MI TTQBR95 DMAGLPW MN Stress-activated protein kinase 2a (p38 alpha) DMAGLPW MT DTT DMAGLPW MA Inhibitor DMAGLPW RN Specificity and mechanism of action of some commonly used protein kinase inhibitors. Biochem J. 2000 Oct 1;351(Pt 1):95-105. DMAGLPW RU https://pubmed.ncbi.nlm.nih.gov/10998351 DMAGLPW DI DMAGLPW DMAGLPW DN RO-316233 DMAGLPW MI TT73U6C DMAGLPW MN Stress-activated protein kinase 2b (p38 beta) DMAGLPW MT DTT DMAGLPW MA Inhibitor DMAGLPW RN Specificity and mechanism of action of some commonly used protein kinase inhibitors. Biochem J. 2000 Oct 1;351(Pt 1):95-105. DMAGLPW RU https://pubmed.ncbi.nlm.nih.gov/10998351 DMAGLPW DI DMAGLPW DMAGLPW DN RO-316233 DMAGLPW MI TT0K6EO DMAGLPW MN Stress-activated protein kinase JNK1 (JNK1) DMAGLPW MT DTT DMAGLPW MA Inhibitor DMAGLPW RN Specificity and mechanism of action of some commonly used protein kinase inhibitors. Biochem J. 2000 Oct 1;351(Pt 1):95-105. DMAGLPW RU https://pubmed.ncbi.nlm.nih.gov/10998351 DMDJLF0 DI DMDJLF0 DMDJLF0 DN Ro31-8220 DMDJLF0 MI TT4TQBX DMDJLF0 MN Extracellular signal-regulated kinase 2 (ERK2) DMDJLF0 MT DTT DMDJLF0 MA Inhibitor DMDJLF0 RN Specificity and mechanism of action of some commonly used protein kinase inhibitors. Biochem J. 2000 Oct 1;351(Pt 1):95-105. DMDJLF0 RU https://pubmed.ncbi.nlm.nih.gov/10998351 DMDJLF0 DI DMDJLF0 DMDJLF0 DN Ro31-8220 DMDJLF0 MI TTRSMW9 DMDJLF0 MN Glycogen synthase kinase-3 beta (GSK-3B) DMDJLF0 MT DTT DMDJLF0 MA Inhibitor DMDJLF0 RN Specificity and mechanism of action of some commonly used protein kinase inhibitors. Biochem J. 2000 Oct 1;351(Pt 1):95-105. DMDJLF0 RU https://pubmed.ncbi.nlm.nih.gov/10998351 DMDJLF0 DI DMDJLF0 DMDJLF0 DN Ro31-8220 DMDJLF0 MI TT860QF DMDJLF0 MN LCK tyrosine protein kinase (LCK) DMDJLF0 MT DTT DMDJLF0 MA Inhibitor DMDJLF0 RN Specificity and mechanism of action of some commonly used protein kinase inhibitors. Biochem J. 2000 Oct 1;351(Pt 1):95-105. DMDJLF0 RU https://pubmed.ncbi.nlm.nih.gov/10998351 DMDJLF0 DI DMDJLF0 DMDJLF0 DN Ro31-8220 DMDJLF0 MI TTYT93M DMDJLF0 MN MAP kinase p38 (MAPK12) DMDJLF0 MT DTT DMDJLF0 MA Inhibitor DMDJLF0 RN Specificity and mechanism of action of some commonly used protein kinase inhibitors. Biochem J. 2000 Oct 1;351(Pt 1):95-105. DMDJLF0 RU https://pubmed.ncbi.nlm.nih.gov/10998351 DMDJLF0 DI DMDJLF0 DMDJLF0 DN Ro31-8220 DMDJLF0 MI TTUF2HO DMDJLF0 MN NAD-dependent deacetylase sirtuin-1 (SIRT1) DMDJLF0 MT DTT DMDJLF0 MA Inhibitor DMDJLF0 RN Adenosine mimetics as inhibitors of NAD+-dependent histone deacetylases, from kinase to sirtuin inhibition. J Med Chem. 2006 Dec 14;49(25):7307-16. DMDJLF0 RU https://pubmed.ncbi.nlm.nih.gov/17149860 DMDJLF0 DI DMDJLF0 DMDJLF0 DN Ro31-8220 DMDJLF0 MI TTFJ8Q1 DMDJLF0 MN Protein kinase C alpha (PRKCA) DMDJLF0 MT DTT DMDJLF0 MA Inhibitor DMDJLF0 RN Specificity and mechanism of action of some commonly used protein kinase inhibitors. Biochem J. 2000 Oct 1;351(Pt 1):95-105. DMDJLF0 RU https://pubmed.ncbi.nlm.nih.gov/10998351 DMDJLF0 DI DMDJLF0 DMDJLF0 DN Ro31-8220 DMDJLF0 MI TTWTSCV DMDJLF0 MN RAC-alpha serine/threonine-protein kinase (AKT1) DMDJLF0 MT DTT DMDJLF0 MA Inhibitor DMDJLF0 RN Specificity and mechanism of action of some commonly used protein kinase inhibitors. Biochem J. 2000 Oct 1;351(Pt 1):95-105. DMDJLF0 RU https://pubmed.ncbi.nlm.nih.gov/10998351 DMDJLF0 DI DMDJLF0 DMDJLF0 DN Ro31-8220 DMDJLF0 MI TTZN7RP DMDJLF0 MN Rho-associated protein kinase 1 (ROCK1) DMDJLF0 MT DTT DMDJLF0 MA Inhibitor DMDJLF0 RN Specificity and mechanism of action of some commonly used protein kinase inhibitors. Biochem J. 2000 Oct 1;351(Pt 1):95-105. DMDJLF0 RU https://pubmed.ncbi.nlm.nih.gov/10998351 DMDJLF0 DI DMDJLF0 DMDJLF0 DN Ro31-8220 DMDJLF0 MI TTG0U4H DMDJLF0 MN Ribosomal protein S6 kinase beta-1 (S6K1) DMDJLF0 MT DTT DMDJLF0 MA Inhibitor DMDJLF0 RN Specificity and mechanism of action of some commonly used protein kinase inhibitors. Biochem J. 2000 Oct 1;351(Pt 1):95-105. DMDJLF0 RU https://pubmed.ncbi.nlm.nih.gov/10998351 DMDJLF0 DI DMDJLF0 DMDJLF0 DN Ro31-8220 DMDJLF0 MI TTQBR95 DMDJLF0 MN Stress-activated protein kinase 2a (p38 alpha) DMDJLF0 MT DTT DMDJLF0 MA Inhibitor DMDJLF0 RN Specificity and mechanism of action of some commonly used protein kinase inhibitors. Biochem J. 2000 Oct 1;351(Pt 1):95-105. DMDJLF0 RU https://pubmed.ncbi.nlm.nih.gov/10998351 DMDJLF0 DI DMDJLF0 DMDJLF0 DN Ro31-8220 DMDJLF0 MI TT73U6C DMDJLF0 MN Stress-activated protein kinase 2b (p38 beta) DMDJLF0 MT DTT DMDJLF0 MA Inhibitor DMDJLF0 RN Specificity and mechanism of action of some commonly used protein kinase inhibitors. Biochem J. 2000 Oct 1;351(Pt 1):95-105. DMDJLF0 RU https://pubmed.ncbi.nlm.nih.gov/10998351 DMDJLF0 DI DMDJLF0 DMDJLF0 DN Ro31-8220 DMDJLF0 MI TT0K6EO DMDJLF0 MN Stress-activated protein kinase JNK1 (JNK1) DMDJLF0 MT DTT DMDJLF0 MA Inhibitor DMDJLF0 RN Specificity and mechanism of action of some commonly used protein kinase inhibitors. Biochem J. 2000 Oct 1;351(Pt 1):95-105. DMDJLF0 RU https://pubmed.ncbi.nlm.nih.gov/10998351 DM9GXYV DI DM9GXYV DM9GXYV DN Ro-3201195 DM9GXYV MI TTQBR95 DM9GXYV MN Stress-activated protein kinase 2a (p38 alpha) DM9GXYV MT DTT DM9GXYV MA Inhibitor DM9GXYV RN Microwave-assisted synthesis of 5-aminopyrazol-4-yl ketones and the p38(MAPK) inhibitor RO3201195 for study in Werner syndrome cells. Bioorg Med Chem Lett. 2008 Jul 1;18(13):3745-8. DM9GXYV RU https://pubmed.ncbi.nlm.nih.gov/18539026 DM8BLYO DI DM8BLYO DM8BLYO DN RO320-2947/001 DM8BLYO MI TTU3Y87 DM8BLYO MN CCR3 messenger RNA (CCR3 mRNA) DM8BLYO MT DTT DM8BLYO MA Antagonist DM8BLYO RN Responses of leukocytes to chemokines in whole blood and their antagonism by novel CC-chemokine receptor 3 antagonists. Am J Respir Crit Care Med. 2002 Jun 15;165(12):1602-9. DM8BLYO RU https://pubmed.ncbi.nlm.nih.gov/12070060 DMPVKEA DI DMPVKEA DMPVKEA DN Ro-32-0557 DMPVKEA MI TTFJ8Q1 DMPVKEA MN Protein kinase C alpha (PRKCA) DMPVKEA MT DTT DMPVKEA MA Inhibitor DMPVKEA RN Bisindolylmaleimide inhibitors of protein kinase C. Further conformational restriction of a tertiary amine side chain, Bioorg. Med. Chem. Lett. 4(11):1303-1308 (1994). DMPVKEA RU http://www.sciencedirect.com/science/article/pii/S0960894X01803498 DMPVKEA DI DMPVKEA DMPVKEA DN Ro-32-0557 DMPVKEA MI TTYPXQF DMPVKEA MN Protein kinase C beta (PRKCB) DMPVKEA MT DTT DMPVKEA MA Inhibitor DMPVKEA RN Bisindolylmaleimide inhibitors of protein kinase C. Further conformational restriction of a tertiary amine side chain, Bioorg. Med. Chem. Lett. 4(11):1303-1308 (1994). DMPVKEA RU http://www.sciencedirect.com/science/article/pii/S0960894X01803498 DMPVKEA DI DMPVKEA DMPVKEA DN Ro-32-0557 DMPVKEA MI TT9WJ8U DMPVKEA MN Protein kinase C delta (PRKCD) DMPVKEA MT DTT DMPVKEA MA Inhibitor DMPVKEA RN Bisindolylmaleimide inhibitors of protein kinase C. Further conformational restriction of a tertiary amine side chain, Bioorg. Med. Chem. Lett. 4(11):1303-1308 (1994). DMPVKEA RU http://www.sciencedirect.com/science/article/pii/S0960894X01803498 DMPVKEA DI DMPVKEA DMPVKEA DN Ro-32-0557 DMPVKEA MI TTBZ7OD DMPVKEA MN Protein kinase C epsilon (PRKCE) DMPVKEA MT DTT DMPVKEA MA Inhibitor DMPVKEA RN Bisindolylmaleimide inhibitors of protein kinase C. Further conformational restriction of a tertiary amine side chain, Bioorg. Med. Chem. Lett. 4(11):1303-1308 (1994). DMPVKEA RU http://www.sciencedirect.com/science/article/pii/S0960894X01803498 DMPVKEA DI DMPVKEA DMPVKEA DN Ro-32-0557 DMPVKEA MI TTRFOXJ DMPVKEA MN Protein kinase C gamma (PRKCG) DMPVKEA MT DTT DMPVKEA MA Inhibitor DMPVKEA RN Bisindolylmaleimide inhibitors of protein kinase C. Further conformational restriction of a tertiary amine side chain, Bioorg. Med. Chem. Lett. 4(11):1303-1308 (1994). DMPVKEA RU http://www.sciencedirect.com/science/article/pii/S0960894X01803498 DMPVKEA DI DMPVKEA DMPVKEA DN Ro-32-0557 DMPVKEA MI TT8QL1J DMPVKEA MN Protein kinase C theta (PRKCQ) DMPVKEA MT DTT DMPVKEA MA Inhibitor DMPVKEA RN Bisindolylmaleimide inhibitors of protein kinase C. Further conformational restriction of a tertiary amine side chain, Bioorg. Med. Chem. Lett. 4(11):1303-1308 (1994). DMPVKEA RU http://www.sciencedirect.com/science/article/pii/S0960894X01803498 DMPVKEA DI DMPVKEA DMPVKEA DN Ro-32-0557 DMPVKEA MI TTUWGRA DMPVKEA MN Protein kinase C zeta (PRKCZ) DMPVKEA MT DTT DMPVKEA MA Inhibitor DMPVKEA RN Bisindolylmaleimide inhibitors of protein kinase C. Further conformational restriction of a tertiary amine side chain, Bioorg. Med. Chem. Lett. 4(11):1303-1308 (1994). DMPVKEA RU http://www.sciencedirect.com/science/article/pii/S0960894X01803498 DMBFCKD DI DMBFCKD DMBFCKD DN RO3244794 DMBFCKD MI TTOFYT1 DMBFCKD MN Prostacyclin receptor (PTGIR) DMBFCKD MT DTT DMBFCKD MA Antagonist DMBFCKD RN RO1138452 and RO3244794: characterization of structurally distinct, potent and selective IP (prostacyclin) receptor antagonists. Br J Pharmacol. 2006 Feb;147(3):335-45. DMBFCKD RU https://pubmed.ncbi.nlm.nih.gov/16331286 DMGOPY1 DI DMGOPY1 DMGOPY1 DN RO330-0802/001 DMGOPY1 MI TTU3Y87 DMGOPY1 MN CCR3 messenger RNA (CCR3 mRNA) DMGOPY1 MT DTT DMGOPY1 MA Antagonist DMGOPY1 RN Responses of leukocytes to chemokines in whole blood and their antagonism by novel CC-chemokine receptor 3 antagonists. Am J Respir Crit Care Med. 2002 Jun 15;165(12):1602-9. DMGOPY1 RU https://pubmed.ncbi.nlm.nih.gov/12070060 DM83QMZ DI DM83QMZ DM83QMZ DN Ro-37-9790 DM83QMZ MI TTMX39J DM83QMZ MN Matrix metalloproteinase-1 (MMP-1) DM83QMZ MT DTT DM83QMZ MA Inhibitor DM83QMZ RN 11,21-Bisphenyl-19-norpregnane derivatives are selective antiglucocorticoids, Bioorg. Med. Chem. Lett. 7(17):2299-2302 (1997). DM83QMZ RU http://www.sciencedirect.com/science/article/pii/S0960894X97003971 DM83QMZ DI DM83QMZ DM83QMZ DN Ro-37-9790 DM83QMZ MI TTHY57M DM83QMZ MN Matrix metalloproteinase-13 (MMP-13) DM83QMZ MT DTT DM83QMZ MA Inhibitor DM83QMZ RN 11,21-Bisphenyl-19-norpregnane derivatives are selective antiglucocorticoids, Bioorg. Med. Chem. Lett. 7(17):2299-2302 (1997). DM83QMZ RU http://www.sciencedirect.com/science/article/pii/S0960894X97003971 DM83QMZ DI DM83QMZ DM83QMZ DN Ro-37-9790 DM83QMZ MI TTLM12X DM83QMZ MN Matrix metalloproteinase-2 (MMP-2) DM83QMZ MT DTT DM83QMZ MA Inhibitor DM83QMZ RN 11,21-Bisphenyl-19-norpregnane derivatives are selective antiglucocorticoids, Bioorg. Med. Chem. Lett. 7(17):2299-2302 (1997). DM83QMZ RU http://www.sciencedirect.com/science/article/pii/S0960894X97003971 DM83QMZ DI DM83QMZ DM83QMZ DN Ro-37-9790 DM83QMZ MI TTUZ2L5 DM83QMZ MN Matrix metalloproteinase-3 (MMP-3) DM83QMZ MT DTT DM83QMZ MA Inhibitor DM83QMZ RN 11,21-Bisphenyl-19-norpregnane derivatives are selective antiglucocorticoids, Bioorg. Med. Chem. Lett. 7(17):2299-2302 (1997). DM83QMZ RU http://www.sciencedirect.com/science/article/pii/S0960894X97003971 DM83QMZ DI DM83QMZ DM83QMZ DN Ro-37-9790 DM83QMZ MI TTGA1IV DM83QMZ MN Matrix metalloproteinase-8 (MMP-8) DM83QMZ MT DTT DM83QMZ MA Inhibitor DM83QMZ RN 11,21-Bisphenyl-19-norpregnane derivatives are selective antiglucocorticoids, Bioorg. Med. Chem. Lett. 7(17):2299-2302 (1997). DM83QMZ RU http://www.sciencedirect.com/science/article/pii/S0960894X97003971 DM83QMZ DI DM83QMZ DM83QMZ DN Ro-37-9790 DM83QMZ MI TT6X50U DM83QMZ MN Matrix metalloproteinase-9 (MMP-9) DM83QMZ MT DTT DM83QMZ MA Inhibitor DM83QMZ RN 11,21-Bisphenyl-19-norpregnane derivatives are selective antiglucocorticoids, Bioorg. Med. Chem. Lett. 7(17):2299-2302 (1997). DM83QMZ RU http://www.sciencedirect.com/science/article/pii/S0960894X97003971 DM8PYAN DI DM8PYAN DM8PYAN DN Ro-40-0655 DM8PYAN MI TTW38KT DM8PYAN MN Retinoic acid receptor alpha (RARA) DM8PYAN MT DTT DM8PYAN MA Agonist DM8PYAN RN Tamibarotene. Drugs Today (Barc). 2007 Aug;43(8):563-8. DM8PYAN RU https://pubmed.ncbi.nlm.nih.gov/17925887 DM5DMCH DI DM5DMCH DM5DMCH DN Ro-4396686 DM5DMCH MI TTW4Y2M DM5DMCH MN cAMP protein kinase type II-beta (PRKAR2B) DM5DMCH MT DTT DM5DMCH MA Inhibitor DM5DMCH RN Biological evaluation of a multi-targeted small molecule inhibitor of tumor-induced angiogenesis. Bioorg Med Chem Lett. 2006 Apr 1;16(7):1950-3. DM5DMCH RU https://pubmed.ncbi.nlm.nih.gov/16460940 DM5DMCH DI DM5DMCH DM5DMCH DN Ro-4396686 DM5DMCH MI TTGKNB4 DM5DMCH MN Epidermal growth factor receptor (EGFR) DM5DMCH MT DTT DM5DMCH MA Inhibitor DM5DMCH RN Biological evaluation of a multi-targeted small molecule inhibitor of tumor-induced angiogenesis. Bioorg Med Chem Lett. 2006 Apr 1;16(7):1950-3. DM5DMCH RU https://pubmed.ncbi.nlm.nih.gov/16460940 DM5DMCH DI DM5DMCH DM5DMCH DN Ro-4396686 DM5DMCH MI TT4TQBX DM5DMCH MN Extracellular signal-regulated kinase 2 (ERK2) DM5DMCH MT DTT DM5DMCH MA Inhibitor DM5DMCH RN Biological evaluation of a multi-targeted small molecule inhibitor of tumor-induced angiogenesis. Bioorg Med Chem Lett. 2006 Apr 1;16(7):1950-3. DM5DMCH RU https://pubmed.ncbi.nlm.nih.gov/16460940 DM5DMCH DI DM5DMCH DM5DMCH DN Ro-4396686 DM5DMCH MI TT1KX2S DM5DMCH MN FGFR4 messenger RNA (FGFR4 mRNA) DM5DMCH MT DTT DM5DMCH MA Inhibitor DM5DMCH RN Biological evaluation of a multi-targeted small molecule inhibitor of tumor-induced angiogenesis. Bioorg Med Chem Lett. 2006 Apr 1;16(7):1950-3. DM5DMCH RU https://pubmed.ncbi.nlm.nih.gov/16460940 DM5DMCH DI DM5DMCH DM5DMCH DN Ro-4396686 DM5DMCH MI TTRLW2X DM5DMCH MN Fibroblast growth factor receptor 1 (FGFR1) DM5DMCH MT DTT DM5DMCH MA Inhibitor DM5DMCH RN Biological evaluation of a multi-targeted small molecule inhibitor of tumor-induced angiogenesis. Bioorg Med Chem Lett. 2006 Apr 1;16(7):1950-3. DM5DMCH RU https://pubmed.ncbi.nlm.nih.gov/16460940 DM5DMCH DI DM5DMCH DM5DMCH DN Ro-4396686 DM5DMCH MI TTGJVQM DM5DMCH MN Fibroblast growth factor receptor 2 (FGFR2) DM5DMCH MT DTT DM5DMCH MA Inhibitor DM5DMCH RN Biological evaluation of a multi-targeted small molecule inhibitor of tumor-induced angiogenesis. Bioorg Med Chem Lett. 2006 Apr 1;16(7):1950-3. DM5DMCH RU https://pubmed.ncbi.nlm.nih.gov/16460940 DM5DMCH DI DM5DMCH DM5DMCH DN Ro-4396686 DM5DMCH MI TTST7KB DM5DMCH MN Fibroblast growth factor receptor 3 (FGFR3) DM5DMCH MT DTT DM5DMCH MA Inhibitor DM5DMCH RN Biological evaluation of a multi-targeted small molecule inhibitor of tumor-induced angiogenesis. Bioorg Med Chem Lett. 2006 Apr 1;16(7):1950-3. DM5DMCH RU https://pubmed.ncbi.nlm.nih.gov/16460940 DM5DMCH DI DM5DMCH DM5DMCH DN Ro-4396686 DM5DMCH MI TTYVI76 DM5DMCH MN Fungal Protein kinase A (Fung ypkA) DM5DMCH MT DTT DM5DMCH MA Inhibitor DM5DMCH RN Biological evaluation of a multi-targeted small molecule inhibitor of tumor-induced angiogenesis. Bioorg Med Chem Lett. 2006 Apr 1;16(7):1950-3. DM5DMCH RU https://pubmed.ncbi.nlm.nih.gov/16460940 DM5DMCH DI DM5DMCH DM5DMCH DN Ro-4396686 DM5DMCH MI TT2B9KF DM5DMCH MN Fyn tyrosine protein kinase (FYN) DM5DMCH MT DTT DM5DMCH MA Inhibitor DM5DMCH RN Biological evaluation of a multi-targeted small molecule inhibitor of tumor-induced angiogenesis. Bioorg Med Chem Lett. 2006 Apr 1;16(7):1950-3. DM5DMCH RU https://pubmed.ncbi.nlm.nih.gov/16460940 DM5DMCH DI DM5DMCH DM5DMCH DN Ro-4396686 DM5DMCH MI TT8FYO9 DM5DMCH MN Platelet-derived growth factor receptor alpha (PDGFRA) DM5DMCH MT DTT DM5DMCH MA Inhibitor DM5DMCH RN Biological evaluation of a multi-targeted small molecule inhibitor of tumor-induced angiogenesis. Bioorg Med Chem Lett. 2006 Apr 1;16(7):1950-3. DM5DMCH RU https://pubmed.ncbi.nlm.nih.gov/16460940 DM5DMCH DI DM5DMCH DM5DMCH DN Ro-4396686 DM5DMCH MI TTI7421 DM5DMCH MN Platelet-derived growth factor receptor beta (PDGFRB) DM5DMCH MT DTT DM5DMCH MA Inhibitor DM5DMCH RN Biological evaluation of a multi-targeted small molecule inhibitor of tumor-induced angiogenesis. Bioorg Med Chem Lett. 2006 Apr 1;16(7):1950-3. DM5DMCH RU https://pubmed.ncbi.nlm.nih.gov/16460940 DM5DMCH DI DM5DMCH DM5DMCH DN Ro-4396686 DM5DMCH MI TT5U49F DM5DMCH MN PRKACA messenger RNA (PRKACA mRNA) DM5DMCH MT DTT DM5DMCH MA Inhibitor DM5DMCH RN Biological evaluation of a multi-targeted small molecule inhibitor of tumor-induced angiogenesis. Bioorg Med Chem Lett. 2006 Apr 1;16(7):1950-3. DM5DMCH RU https://pubmed.ncbi.nlm.nih.gov/16460940 DM5DMCH DI DM5DMCH DM5DMCH DN Ro-4396686 DM5DMCH MI TTUTJGQ DM5DMCH MN Vascular endothelial growth factor receptor 2 (KDR) DM5DMCH MT DTT DM5DMCH MA Inhibitor DM5DMCH RN Biological evaluation of a multi-targeted small molecule inhibitor of tumor-induced angiogenesis. Bioorg Med Chem Lett. 2006 Apr 1;16(7):1950-3. DM5DMCH RU https://pubmed.ncbi.nlm.nih.gov/16460940 DMJLSX0 DI DMJLSX0 DMJLSX0 DN Ro4491533 DMJLSX0 MI TTXJ47W DMJLSX0 MN Metabotropic glutamate receptor 2 (mGluR2) DMJLSX0 MT DTT DMJLSX0 MA Modulator (allosteric modulator) DMJLSX0 RN Characterization of an mGluR2/3 negative allosteric modulator in rodent models of depression. J Neurogenet. 2011 Dec;25(4):152-66. DMJLSX0 RU https://pubmed.ncbi.nlm.nih.gov/22091727 DMJLSX0 DI DMJLSX0 DMJLSX0 DN Ro4491533 DMJLSX0 MI TT8A9EF DMJLSX0 MN Metabotropic glutamate receptor 3 (mGluR3) DMJLSX0 MT DTT DMJLSX0 MA Modulator (allosteric modulator) DMJLSX0 RN Synthesis and characterization of 1,3-dihydro-benzo[b][1,4]diazepin-2-one derivatives: Part 4. In vivo active potent and selective non-competitive metabotropic glutamate receptor 2/3 antagonists. Bioorg Med Chem Lett. 2010 Dec 1;20(23):6969-74. DMJLSX0 RU https://pubmed.ncbi.nlm.nih.gov/20971004 DMC0V25 DI DMC0V25 DMC0V25 DN RO-4840700 DMC0V25 MI TTHJTF7 DMC0V25 MN Glycine transporter GlyT-1 (SLC6A9) DMC0V25 MT DTT DMC0V25 MA Inhibitor DMC0V25 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 935). DMC0V25 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=935 DMVGITD DI DMVGITD DMVGITD DN Ro48-8071 DMVGITD MI TT7O8ZA DMVGITD MN Lanosterol synthase (LSS) DMVGITD MT DTT DMVGITD MA Inhibitor DMVGITD RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMVGITD RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMD9SCI DI DMD9SCI DMD9SCI DN RO-4920506 DMD9SCI MI TTROQ37 DMD9SCI MN MAPK/ERK kinase kinase (MAP3K) DMD9SCI MT DTT DMD9SCI MA Inhibitor DMD9SCI RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2063). DMD9SCI RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2063 DMCB2N9 DI DMCB2N9 DMCB2N9 DN Ro-4938581 DMCB2N9 MI TT1MPAY DMCB2N9 MN GABA(A) receptor alpha-1 (GABRA1) DMCB2N9 MT DTT DMCB2N9 MA Inhibitor DMCB2N9 RN The discovery and unique pharmacological profile of RO4938581 and RO4882224 as potent and selective GABAA alpha5 inverse agonists for the treatment... Bioorg Med Chem Lett. 2009 Oct 15;19(20):5940-4. DMCB2N9 RU https://pubmed.ncbi.nlm.nih.gov/19762240 DMCB2N9 DI DMCB2N9 DMCB2N9 DN Ro-4938581 DMCB2N9 MI TTBMV1G DMCB2N9 MN GABA(A) receptor alpha-2 (GABRA2) DMCB2N9 MT DTT DMCB2N9 MA Inhibitor DMCB2N9 RN The discovery and unique pharmacological profile of RO4938581 and RO4882224 as potent and selective GABAA alpha5 inverse agonists for the treatment... Bioorg Med Chem Lett. 2009 Oct 15;19(20):5940-4. DMCB2N9 RU https://pubmed.ncbi.nlm.nih.gov/19762240 DMCB2N9 DI DMCB2N9 DMCB2N9 DN Ro-4938581 DMCB2N9 MI TT37EDJ DMCB2N9 MN GABA(A) receptor alpha-3 (GABRA3) DMCB2N9 MT DTT DMCB2N9 MA Inhibitor DMCB2N9 RN The discovery and unique pharmacological profile of RO4938581 and RO4882224 as potent and selective GABAA alpha5 inverse agonists for the treatment... Bioorg Med Chem Lett. 2009 Oct 15;19(20):5940-4. DMCB2N9 RU https://pubmed.ncbi.nlm.nih.gov/19762240 DMCB2N9 DI DMCB2N9 DMCB2N9 DN Ro-4938581 DMCB2N9 MI TTNZPQ1 DMCB2N9 MN GABA(A) receptor alpha-5 (GABRA5) DMCB2N9 MT DTT DMCB2N9 MA Inhibitor DMCB2N9 RN The discovery and unique pharmacological profile of RO4938581 and RO4882224 as potent and selective GABAA alpha5 inverse agonists for the treatment... Bioorg Med Chem Lett. 2009 Oct 15;19(20):5940-4. DMCB2N9 RU https://pubmed.ncbi.nlm.nih.gov/19762240 DMCB2N9 DI DMCB2N9 DMCB2N9 DN Ro-4938581 DMCB2N9 MI TT06RH5 DMCB2N9 MN GABA(A) receptor gamma-2 (GABRG2) DMCB2N9 MT DTT DMCB2N9 MA Inhibitor DMCB2N9 RN The discovery and unique pharmacological profile of RO4938581 and RO4882224 as potent and selective GABAA alpha5 inverse agonists for the treatment... Bioorg Med Chem Lett. 2009 Oct 15;19(20):5940-4. DMCB2N9 RU https://pubmed.ncbi.nlm.nih.gov/19762240 DMCB2N9 DI DMCB2N9 DMCB2N9 DN Ro-4938581 DMCB2N9 MI TTNJYV2 DMCB2N9 MN Gamma-aminobutyric acid receptor (GAR) DMCB2N9 MT DTT DMCB2N9 MA Inhibitor DMCB2N9 RN The discovery and unique pharmacological profile of RO4938581 and RO4882224 as potent and selective GABAA alpha5 inverse agonists for the treatment... Bioorg Med Chem Lett. 2009 Oct 15;19(20):5940-4. DMCB2N9 RU https://pubmed.ncbi.nlm.nih.gov/19762240 DM6SQ9A DI DM6SQ9A DM6SQ9A DN RO4988546 DM6SQ9A MI TTXJ47W DM6SQ9A MN Metabotropic glutamate receptor 2 (mGluR2) DM6SQ9A MT DTT DM6SQ9A MA Modulator (allosteric modulator) DM6SQ9A RN Structural determinants of allosteric antagonism at metabotropic glutamate receptor 2: mechanistic studies with new potent negative allosteric modulators. Br J Pharmacol. 2011 Sep;164(2b):521-37. DM6SQ9A RU https://pubmed.ncbi.nlm.nih.gov/21470207 DMPXC9L DI DMPXC9L DMPXC9L DN RO5101576 DMPXC9L MI TTVJX54 DMPXC9L MN Leukotriene B4 receptor 2 (LTB4R2) DMPXC9L MT DTT DMPXC9L MA Antagonist DMPXC9L RN Effects of LTB4 receptor antagonism on pulmonary inflammation in rodents and non-human primates. Prostaglandins Other Lipid Mediat. 2010 Jun;92(1-4):33-43. DMPXC9L RU https://pubmed.ncbi.nlm.nih.gov/20214997 DM57UB9 DI DM57UB9 DM57UB9 DN RO5166017 DM57UB9 MI TTIU98M DM57UB9 MN Trace amine-associated receptor-1 (TAAR1) DM57UB9 MT DTT DM57UB9 MA Agonist DM57UB9 RN TAAR1 activation modulates monoaminergic neurotransmission, preventing hyperdopaminergic and hypoglutamatergic activity. Proc Natl Acad Sci U S A. 2011 May 17;108(20):8485-90. DM57UB9 RU https://pubmed.ncbi.nlm.nih.gov/21525407 DM42UK5 DI DM42UK5 DM42UK5 DN Ro5203280 DM42UK5 MI TTIYVQP DM42UK5 MN Polo-like kinase 1 (PLK1) DM42UK5 MT DTT DM42UK5 MA Inhibitor DM42UK5 RN Polo-like kinase inhibitor Ro5203280 has potent antitumor activity in nasopharyngeal carcinoma.Mol Cancer Ther. 2013 Aug;12(8):1393-401. DM42UK5 RU https://pubmed.ncbi.nlm.nih.gov/23686835 DMP0GA6 DI DMP0GA6 DMP0GA6 DN RO-5212651 DMP0GA6 MI TT7QNVC DMP0GA6 MN Glucose-dependent insulinotropic receptor (GPR119) DMP0GA6 MT DTT DMP0GA6 MA Agonist DMP0GA6 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 126). DMP0GA6 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=126 DMHXGCO DI DMHXGCO DMHXGCO DN RO5488608 DMHXGCO MI TTXJ47W DMHXGCO MN Metabotropic glutamate receptor 2 (mGluR2) DMHXGCO MT DTT DMHXGCO MA Modulator (allosteric modulator) DMHXGCO RN Structural determinants of allosteric antagonism at metabotropic glutamate receptor 2: mechanistic studies with new potent negative allosteric modulators. Br J Pharmacol. 2011 Sep;164(2b):521-37. DMHXGCO RU https://pubmed.ncbi.nlm.nih.gov/21470207 DMXOTHC DI DMXOTHC DMXOTHC DN Ro64-5229 DMXOTHC MI TTXJ47W DMXOTHC MN Metabotropic glutamate receptor 2 (mGluR2) DMXOTHC MT DTT DMXOTHC MA Modulator (allosteric modulator) DMXOTHC RN Synthesis of heterocyclic enol ethers and their use as group 2 metabotropic glutamate receptor antagonists. Bioorg Med Chem Lett. 1999 Aug 2;9(15):2173-6. DMXOTHC RU https://pubmed.ncbi.nlm.nih.gov/10465539 DM6S742 DI DM6S742 DM6S742 DN Ro-65-7219 DM6S742 MI TTB2MXP DM6S742 MN Angiotensinogenase renin (REN) DM6S742 MT DTT DM6S742 MA Inhibitor DM6S742 RN Direct renin inhibitors as a new therapy for hypertension. J Med Chem. 2010 Nov 11;53(21):7490-520. DM6S742 RU https://pubmed.ncbi.nlm.nih.gov/20731374 DMPT01J DI DMPT01J DMPT01J DN Ro-66-1168 DMPT01J MI TTB2MXP DMPT01J MN Angiotensinogenase renin (REN) DMPT01J MT DTT DMPT01J MA Inhibitor DMPT01J RN Design and preparation of potent, nonpeptidic, bioavailable renin inhibitors. J Med Chem. 2009 Jun 25;52(12):3689-702. DMPT01J RU https://pubmed.ncbi.nlm.nih.gov/19358611 DMD93NP DI DMD93NP DMD93NP DN Ro67-4853 DMD93NP MI TTVBPDM DMD93NP MN Metabotropic glutamate receptor 1 (mGluR1) DMD93NP MT DTT DMD93NP MA Modulator (allosteric modulator) DMD93NP RN Positive allosteric modulators of metabotropic glutamate 1 receptor: characterization, mechanism of action, and binding site. Proc Natl Acad Sci U S A. 2001 Nov 6;98(23):13402-7. DMD93NP RU https://pubmed.ncbi.nlm.nih.gov/11606768 DMI95DP DI DMI95DP DMI95DP DN Ro67-7476 DMI95DP MI TTVBPDM DMI95DP MN Metabotropic glutamate receptor 1 (mGluR1) DMI95DP MT DTT DMI95DP MA Modulator (allosteric modulator) DMI95DP RN Positive allosteric modulators of metabotropic glutamate 1 receptor: characterization, mechanism of action, and binding site. Proc Natl Acad Sci U S A. 2001 Nov 6;98(23):13402-7. DMI95DP RU https://pubmed.ncbi.nlm.nih.gov/11606768 DMASOWP DI DMASOWP DMASOWP DN ROBINETIN DMASOWP MI TT7RJY8 DMASOWP MN Xanthine dehydrogenase/oxidase (XDH) DMASOWP MT DTT DMASOWP MA Inhibitor DMASOWP RN Inhibition of cow's milk xanthine oxidase by flavonoids. J Nat Prod. 1988 Mar-Apr;51(2):345-8. DMASOWP RU https://pubmed.ncbi.nlm.nih.gov/3379415 DME9VTX DI DME9VTX DME9VTX DN ROCAGLAMIDE DME9VTX MI TTSXVID DME9VTX MN Nuclear factor NF-kappa-B (NFKB) DME9VTX MT DTT DME9VTX MA Inhibitor DME9VTX RN Cytotoxic and NF-kappaB inhibitory constituents of Artocarpus rigida. J Nat Prod. 2010 May 28;73(5):949-55. DME9VTX RU https://pubmed.ncbi.nlm.nih.gov/20384315 DMD4JHK DI DMD4JHK DMD4JHK DN Roche 28-2653 DMD4JHK MI TTLM12X DMD4JHK MN Matrix metalloproteinase-2 (MMP-2) DMD4JHK MT DTT DMD4JHK MA Inhibitor DMD4JHK RN The new synthetic matrix metalloproteinase inhibitor (Roche 28-2653) reduces tumor growth and prolongs survival in a prostate cancer standard rat model. Oncogene. 2002 Mar 27;21(13):2089-96. DMD4JHK RU https://pubmed.ncbi.nlm.nih.gov/11960381 DMD4JHK DI DMD4JHK DMD4JHK DN Roche 28-2653 DMD4JHK MI TT6X50U DMD4JHK MN Matrix metalloproteinase-9 (MMP-9) DMD4JHK MT DTT DMD4JHK MA Inhibitor DMD4JHK RN The new synthetic matrix metalloproteinase inhibitor (Roche 28-2653) reduces tumor growth and prolongs survival in a prostate cancer standard rat model. Oncogene. 2002 Mar 27;21(13):2089-96. DMD4JHK RU https://pubmed.ncbi.nlm.nih.gov/11960381 DMOTPJD DI DMOTPJD DMOTPJD DN Rockout DMOTPJD MI TTTB4UP DMOTPJD MN Inosine-5'-monophosphate dehydrogenase 2 (IMPDH2) DMOTPJD MT DTT DMOTPJD MA Inhibitor DMOTPJD RN Novel indole inhibitors of IMPDH from fragments: synthesis and initial structure-activity relationships. Bioorg Med Chem Lett. 2006 May 1;16(9):2539-42. DMOTPJD RU https://pubmed.ncbi.nlm.nih.gov/16483773 DM5HV4W DI DM5HV4W DM5HV4W DN Rolicyclidine DM5HV4W MI TTEX248 DM5HV4W MN Dopamine D2 receptor (D2R) DM5HV4W MT DTT DM5HV4W MA Inhibitor DM5HV4W RN 4-Acetoxy-7-chloro-3-(3-(-4-[11C]methoxybenzyl)phenyl)-2(1H)-quinolone Molecular Imaging and Contrast Agent Database (MICAD) [Internet]. DM5HV4W RU https://pubmed.ncbi.nlm.nih.gov/20641908 DMJ03UM DI DMJ03UM DMJ03UM DN ROLIPRAM DMJ03UM MI TTZ97H5 DMJ03UM MN Phosphodiesterase 4A (PDE4A) DMJ03UM MT DTT DMJ03UM MA Inhibitor DMJ03UM RN Discovery of micromolar PDE IV inhibitors that exhibit much reduced affinity for the [3H]rolipram binding site: 3-norbornyloxy-4-methoxyphenylmethylene oxindoles, Bioorg. Med. Chem. Lett. 5(17):1965-1968 (1995). DMJ03UM RU http://www.sciencedirect.com/science/article/pii/0960894X9500333O DMJ03UM DI DMJ03UM DMJ03UM DN ROLIPRAM DMJ03UM MI TTVIAT9 DMJ03UM MN Phosphodiesterase 4B (PDE4B) DMJ03UM MT DTT DMJ03UM MA Inhibitor DMJ03UM RN Novel heterocyclic-fused pyridazinones as potent and selective phosphodiesterase IV inhibitors. J Med Chem. 1997 May 9;40(10):1417-21. DMJ03UM RU https://pubmed.ncbi.nlm.nih.gov/9154964 DMJ03UM DI DMJ03UM DMJ03UM DN ROLIPRAM DMJ03UM MI TTSKMI8 DMJ03UM MN Phosphodiesterase 4D (PDE4D) DMJ03UM MT DTT DMJ03UM MA Inhibitor DMJ03UM RN In silico search for multi-target anti-inflammatories in Chinese herbs and formulas. Bioorg Med Chem. 2010 Mar 15;18(6):2204-2218. DMJ03UM RU https://pubmed.ncbi.nlm.nih.gov/20188577 DMJ03UM DI DMJ03UM DMJ03UM DN ROLIPRAM DMJ03UM MI TTJ0IQB DMJ03UM MN Phosphodiesterase 5A (PDE5A) DMJ03UM MT DTT DMJ03UM MA Inhibitor DMJ03UM RN Cyclic GMP phosphodiesterase inhibitors. 2. Requirement of 6-substitution of quinazoline derivatives for potent and selective inhibitory activity. J Med Chem. 1994 Jun 24;37(13):2106-11. DMJ03UM RU https://pubmed.ncbi.nlm.nih.gov/8027992 DMAROW1 DI DMAROW1 DMAROW1 DN ROMe DMAROW1 MI TTCN0M9 DMAROW1 MN Sphingosine kinase 2 (SPHK2) DMAROW1 MT DTT DMAROW1 MA Inhibitor DMAROW1 RN (R)-FTY720 methyl ether is a specific sphingosine kinase 2 inhibitor: Effect on sphingosine kinase 2 expression in HEK 293 cells and actin rearrangement and survival of MCF-7 breast cancer cells. Cell Signal. 2011 Oct;23(10):1590-5. DMAROW1 RU https://pubmed.ncbi.nlm.nih.gov/21620961 DM3NBQ6 DI DM3NBQ6 DM3NBQ6 DN rose bengal (photoactivated) DM3NBQ6 MI TTXF0ZW DM3NBQ6 MN Inward rectifier potassium channel Kir2.3 (KCNJ4) DM3NBQ6 MT DTT DM3NBQ6 MA Inhibitor (gating inhibitor) DM3NBQ6 RN Susceptibility of cloned K+ channels to reactive oxygen species. Proc Natl Acad Sci U S A. 1995 Dec 5;92(25):11796-800. DM3NBQ6 RU https://pubmed.ncbi.nlm.nih.gov/8524851 DMN802V DI DMN802V DMN802V DN ROSETTACIN DMN802V MI TTGTQHC DMN802V MN DNA topoisomerase I (TOP1) DMN802V MT DTT DMN802V MA Inhibitor DMN802V RN Synthesis and biological evaluation of 14-(aminoalkyl-aminomethyl)aromathecins as topoisomerase I inhibitors: investigating the hypothesis of share... Bioorg Med Chem. 2009 Oct 15;17(20):7145-55. DMN802V RU https://pubmed.ncbi.nlm.nih.gov/19783447 DMQ6SJT DI DMQ6SJT DMQ6SJT DN ROSMARINIC ACID DMQ6SJT MI TTL53M6 DMQ6SJT MN Induced myeloid leukemia cell differentiation protein Mcl-1 (MCL1) DMQ6SJT MT DTT DMQ6SJT MA Inhibitor DMQ6SJT RN In silico identification and biochemical evaluation of novel inhibitors of NRH:quinone oxidoreductase 2 (NQO2). Bioorg Med Chem Lett. 2010 Dec 15;20(24):7331-6. DMQ6SJT RU https://pubmed.ncbi.nlm.nih.gov/21074425 DMQ6SJT DI DMQ6SJT DMQ6SJT DN ROSMARINIC ACID DMQ6SJT MI TTULVH8 DMQ6SJT MN Tyrosinase (TYR) DMQ6SJT MT DTT DMQ6SJT MA Inhibitor DMQ6SJT RN A novel ring-expanded product with enhanced tyrosinase inhibitory activity from classical Fe-catalyzed oxidation of rosmarinic acid, a potent antio... Bioorg Med Chem Lett. 2010 Dec 15;20(24):7393-6. DMQ6SJT RU https://pubmed.ncbi.nlm.nih.gov/21041086 DMT0DW4 DI DMT0DW4 DMT0DW4 DN Rotigitine DMT0DW4 MI TTEX248 DMT0DW4 MN Dopamine D2 receptor (D2R) DMT0DW4 MT DTT DMT0DW4 MA Agonist DMT0DW4 RN Novel pharmacological targets for the treatment of Parkinson's disease. Nat Rev Drug Discov. 2006 Oct;5(10):845-54. DMT0DW4 RU https://pubmed.ncbi.nlm.nih.gov/17016425 DM751OH DI DM751OH DM751OH DN Rotungenic acid DM751OH MI TTELIN2 DM751OH MN PTPN1 messenger RNA (PTPN1 mRNA) DM751OH MT DTT DM751OH MA Inhibitor DM751OH RN Triterpenoids from the leaves of Diospyros kaki (persimmon) and their inhibitory effects on protein tyrosine phosphatase 1B. J Nat Prod. 2008 Oct;71(10):1775-8. DM751OH RU https://pubmed.ncbi.nlm.nih.gov/18798681 DMWUAMQ DI DMWUAMQ DMWUAMQ DN ROXIFIBAN DMWUAMQ MI TTJA1ZO DMWUAMQ MN ITGB3 messenger RNA (ITGB3 mRNA) DMWUAMQ MT DTT DMWUAMQ MA Inhibitor DMWUAMQ RN Platelet glycoprotein IIb-IIIa antagonists as prototypical integrin blockers: novel parenteral and potential oral antithrombotic agents. J Med Chem. 2000 Sep 21;43(19):3453-73. DMWUAMQ RU https://pubmed.ncbi.nlm.nih.gov/10999999 DMP2EDX DI DMP2EDX DMP2EDX DN RP-1040 DMP2EDX MI TTNDSF4 DMP2EDX MN Proto-oncogene c-Met (MET) DMP2EDX MT DTT DMP2EDX MA Inhibitor DMP2EDX RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1815). DMP2EDX RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1815 DM5IXOS DI DM5IXOS DM5IXOS DN RP-52770 DM5IXOS MI TTQL5VC DM5IXOS MN Platelet-activating factor receptor (PTAFR) DM5IXOS MT DTT DM5IXOS MA Antagonist DM5IXOS RN [3H]52770 RP, a platelet-activating factor receptor antagonist, and tritiated platelet-activating factor label a common specific binding site in human polymorphonuclear leukocytes. J Pharmacol Exp Ther. 1988 Feb;244(2):709-15. DM5IXOS RU https://pubmed.ncbi.nlm.nih.gov/2831350 DM03RIT DI DM03RIT DM03RIT DN Rp-5-OMe-UDPalphaB DM03RIT MI TTNVSKA DM03RIT MN P2Y purinoceptor 6 (P2RY6) DM03RIT MT DTT DM03RIT MA Agonist DM03RIT RN 5-OMe-uridine-5'-O-(alpha-boranodiphosphate), a novel nucleotide derivative highly active at the human P2Y(6) receptor protects against death-receptor mediated glial apoptosis. Neurosci Lett. 2014 Aug 22;578:80-4. DM03RIT RU https://pubmed.ncbi.nlm.nih.gov/24970757 DMR4O3I DI DMR4O3I DMR4O3I DN RP-66471 DMR4O3I MI TT1VOHK DMR4O3I MN Potassium channel unspecific (KC) DMR4O3I MT DTT DMR4O3I MA Modulator DMR4O3I RN Potassium channel opener, RP 66471, induces membrane depolarization of rat liver mitochondria. Biochem Biophys Res Commun. 1995 Feb 6;207(1):126-32. DMR4O3I RU https://www.ncbi.nlm.nih.gov/pubmed/7857254 DMXMRVG DI DMXMRVG DMXMRVG DN RP-69758 DMXMRVG MI TTVFO0U DMXMRVG MN Gastrin/cholecystokinin type B receptor (CCKBR) DMXMRVG MT DTT DMXMRVG MA Antagonist DMXMRVG RN Pharmacological properties of ureido-acetamides, new potent and selective non-peptide CCKB/gastrin receptor antagonists. Eur J Pharmacol. 1994 Sep 12;262(3):233-45. DMXMRVG RU https://pubmed.ncbi.nlm.nih.gov/7813588 DMUFLNT DI DMUFLNT DMUFLNT DN RP-71483 DMUFLNT MI TTVFO0U DMUFLNT MN Gastrin/cholecystokinin type B receptor (CCKBR) DMUFLNT MT DTT DMUFLNT MA Modulator DMUFLNT RN Pharmacological properties of ureido-acetamides, new potent and selective non-peptide CCKB/gastrin receptor antagonists. Eur J Pharmacol. 1994 Sep 12;262(3):233-45. DMUFLNT RU https://pubmed.ncbi.nlm.nih.gov/7813588 DMWIXQS DI DMWIXQS DMWIXQS DN RP-72540 DMWIXQS MI TTVFO0U DMWIXQS MN Gastrin/cholecystokinin type B receptor (CCKBR) DMWIXQS MT DTT DMWIXQS MA Modulator DMWIXQS RN Pharmacological properties of ureido-acetamides, new potent and selective non-peptide CCKB/gastrin receptor antagonists. Eur J Pharmacol. 1994 Sep 12;262(3):233-45. DMWIXQS RU https://pubmed.ncbi.nlm.nih.gov/7813588 DMLKPZ6 DI DMLKPZ6 DMLKPZ6 DN RP73870 DMLKPZ6 MI TTVFO0U DMLKPZ6 MN Gastrin/cholecystokinin type B receptor (CCKBR) DMLKPZ6 MT DTT DMLKPZ6 MA Antagonist DMLKPZ6 RN Pharmacological analysis of CCK2 receptor antagonists using isolated rat stomach ECL cells. Br J Pharmacol. 1999 May;127(2):530-6. DMLKPZ6 RU https://pubmed.ncbi.nlm.nih.gov/10385255 DMJMC43 DI DMJMC43 DMJMC43 DN Rp-8-CPT-cGMPS DMJMC43 MI TT7IZSA DMJMC43 MN Protein kinase G1 (PRKG1) DMJMC43 MT DTT DMJMC43 MA Inhibitor DMJMC43 RN (Rp)-8-pCPT-cGMPS, a novel cGMP-dependent protein kinase inhibitor. Eur J Pharmacol. 1994 Oct 14;269(2):265-8. DMJMC43 RU https://pubmed.ncbi.nlm.nih.gov/7851503 DM1JWGH DI DM1JWGH DM1JWGH DN Rp-adenosine 3',5'-cyclic monophosphothioate triethylamine (Rp-cAMPS) DM1JWGH MI TTYVI76 DM1JWGH MN Fungal Protein kinase A (Fung ypkA) DM1JWGH MT DTT DM1JWGH MA Inhibitor DM1JWGH RN Inhibition of protein kinase A activity interferes with long-term, but not short-term, memory of conditioned taste aversions. Behav Neurosci. 2002 Dec;116(6):1070-4. DM1JWGH RU https://pubmed.ncbi.nlm.nih.gov/12492305 DMG0S9B DI DMG0S9B DMG0S9B DN Rp-cAMPS DMG0S9B MI TTYVI76 DMG0S9B MN Fungal Protein kinase A (Fung ypkA) DMG0S9B MT DTT DMG0S9B MA Inhibitor DMG0S9B RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1694). DMG0S9B RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1694 DMAROTU DI DMAROTU DMAROTU DN RPKPfQwFwLL-NH2 DMAROTU MI TTWDC17 DMAROTU MN Growth hormone secretagogue receptor 1 (GHSR) DMAROTU MT DTT DMAROTU MA Inhibitor DMAROTU RN Identification of an efficacy switch region in the ghrelin receptor responsible for interchange between agonism and inverse agonism. J Biol Chem. 2007 May 25;282(21):15799-811. DMAROTU RU https://pubmed.ncbi.nlm.nih.gov/17371869 DM0HD3O DI DM0HD3O DM0HD3O DN RPR-101511 DM0HD3O MI TT8FYO9 DM0HD3O MN Platelet-derived growth factor receptor alpha (PDGFRA) DM0HD3O MT DTT DM0HD3O MA Inhibitor DM0HD3O RN A new series of PDGF receptor tyrosine kinase inhibitors: 3-substituted quinoline derivatives. J Med Chem. 1994 Jul 8;37(14):2129-37. DM0HD3O RU https://pubmed.ncbi.nlm.nih.gov/8035419 DM0HD3O DI DM0HD3O DM0HD3O DN RPR-101511 DM0HD3O MI TTI7421 DM0HD3O MN Platelet-derived growth factor receptor beta (PDGFRB) DM0HD3O MT DTT DM0HD3O MA Inhibitor DM0HD3O RN A new series of PDGF receptor tyrosine kinase inhibitors: 3-substituted quinoline derivatives. J Med Chem. 1994 Jul 8;37(14):2129-37. DM0HD3O RU https://pubmed.ncbi.nlm.nih.gov/8035419 DM9ODEZ DI DM9ODEZ DM9ODEZ DN RPR-107836 DM9ODEZ MI TTVFO0U DM9ODEZ MN Gastrin/cholecystokinin type B receptor (CCKBR) DM9ODEZ MT DTT DM9ODEZ MA Modulator DM9ODEZ RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 77). DM9ODEZ RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=77 DM37I92 DI DM37I92 DM37I92 DN RPR-108514A DM37I92 MI TT8FYO9 DM37I92 MN Platelet-derived growth factor receptor alpha (PDGFRA) DM37I92 MT DTT DM37I92 MA Inhibitor DM37I92 RN The synthesis and SAR of new 4-(N-alkyl-N-phenyl)amino-6,7-dimethoxyquinazolines and 4-(N-alkyl-N-phenyl)aminopyrazolo[3,4-d]pyrimidines, inhibitors of CSF-1R tyrosine kinase activity, Bioorg. Med. Chem. Lett. 7(4):421-424 (1997). DM37I92 RU http://www.sciencedirect.com/science/article/pii/S0960894X97000358 DM37I92 DI DM37I92 DM37I92 DN RPR-108514A DM37I92 MI TTI7421 DM37I92 MN Platelet-derived growth factor receptor beta (PDGFRB) DM37I92 MT DTT DM37I92 MA Inhibitor DM37I92 RN The synthesis and SAR of new 4-(N-alkyl-N-phenyl)amino-6,7-dimethoxyquinazolines and 4-(N-alkyl-N-phenyl)aminopyrazolo[3,4-d]pyrimidines, inhibitors of CSF-1R tyrosine kinase activity, Bioorg. Med. Chem. Lett. 7(4):421-424 (1997). DM37I92 RU http://www.sciencedirect.com/science/article/pii/S0960894X97000358 DMJ6RZI DI DMJ6RZI DMJ6RZI DN RPR-108518A DMJ6RZI MI TT860QF DMJ6RZI MN LCK tyrosine protein kinase (LCK) DMJ6RZI MT DTT DMJ6RZI MA Inhibitor DMJ6RZI RN he preparation and sar of 4-(anilino), 4-(phenoxy), and 4-(thiophenoxy)-quinazolines: Inhibitors of p56lck and EGF-R tyrosine kinase activity, Bioorg. Med. Chem. Lett. 7(4):417-420 (1997). DMJ6RZI RU http://www.sciencedirect.com/science/article/pii/S0960894X97000346 DM61VHF DI DM61VHF DM61VHF DN RPR-118071 DM61VHF MI TTZUXYS DM61VHF MN Vitamin K-dependent protein C (PROC) DM61VHF MT DTT DM61VHF MA Inhibitor DM61VHF RN Design and structure-activity relationships of potent and selective inhibitors of blood coagulation factor Xa. J Med Chem. 1999 Sep 9;42(18):3557-71. DM61VHF RU https://pubmed.ncbi.nlm.nih.gov/10479288 DMLDWCB DI DMLDWCB DMLDWCB DN RPR-118723 DMLDWCB MI TTAN6JD DMLDWCB MN Glutamate receptor AMPA (GRIA) DMLDWCB MT DTT DMLDWCB MA Inhibitor DMLDWCB RN Indeno[1,2-b]pyrazin-2,3-diones: a new class of antagonists at the glycine site of the NMDA receptor with potent in vivo activity. J Med Chem. 2000 Jun 15;43(12):2371-81. DMLDWCB RU https://pubmed.ncbi.nlm.nih.gov/10882363 DMLDWCB DI DMLDWCB DMLDWCB DN RPR-118723 DMLDWCB MI TTVPQTF DMLDWCB MN Glutamate receptor AMPA 1 (GRIA1) DMLDWCB MT DTT DMLDWCB MA Inhibitor DMLDWCB RN Indeno[1,2-b]pyrazin-2,3-diones: a new class of antagonists at the glycine site of the NMDA receptor with potent in vivo activity. J Med Chem. 2000 Jun 15;43(12):2371-81. DMLDWCB RU https://pubmed.ncbi.nlm.nih.gov/10882363 DMLDWCB DI DMLDWCB DMLDWCB DN RPR-118723 DMLDWCB MI TTLD29N DMLDWCB MN Glutamate receptor ionotropic NMDA 1 (NMDAR1) DMLDWCB MT DTT DMLDWCB MA Inhibitor DMLDWCB RN Indeno[1,2-b]pyrazin-2,3-diones: a new class of antagonists at the glycine site of the NMDA receptor with potent in vivo activity. J Med Chem. 2000 Jun 15;43(12):2371-81. DMLDWCB RU https://pubmed.ncbi.nlm.nih.gov/10882363 DMLDWCB DI DMLDWCB DMLDWCB DN RPR-118723 DMLDWCB MI TTKJEMQ DMLDWCB MN Glutamate receptor ionotropic NMDA 2A (NMDAR2A) DMLDWCB MT DTT DMLDWCB MA Inhibitor DMLDWCB RN Indeno[1,2-b]pyrazin-2,3-diones: a new class of antagonists at the glycine site of the NMDA receptor with potent in vivo activity. J Med Chem. 2000 Jun 15;43(12):2371-81. DMLDWCB RU https://pubmed.ncbi.nlm.nih.gov/10882363 DMLDWCB DI DMLDWCB DMLDWCB DN RPR-118723 DMLDWCB MI TTN9D8E DMLDWCB MN Glutamate receptor ionotropic NMDA 2B (NMDAR2B) DMLDWCB MT DTT DMLDWCB MA Inhibitor DMLDWCB RN Indeno[1,2-b]pyrazin-2,3-diones: a new class of antagonists at the glycine site of the NMDA receptor with potent in vivo activity. J Med Chem. 2000 Jun 15;43(12):2371-81. DMLDWCB RU https://pubmed.ncbi.nlm.nih.gov/10882363 DM1V0MD DI DM1V0MD DM1V0MD DN RPR-120844 DM1V0MD MI TTZUXYS DM1V0MD MN Vitamin K-dependent protein C (PROC) DM1V0MD MT DTT DM1V0MD MA Inhibitor DM1V0MD RN Design and structure-activity relationships of potent and selective inhibitors of blood coagulation factor Xa. J Med Chem. 1999 Sep 9;42(18):3557-71. DM1V0MD RU https://pubmed.ncbi.nlm.nih.gov/10479288 DM9DXHM DI DM9DXHM DM9DXHM DN RPR121154 DM9DXHM MI TTHXFA1 DM9DXHM MN C5a anaphylatoxin chemotactic receptor (C5AR1) DM9DXHM MT DTT DM9DXHM MA Antagonist DM9DXHM RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 32). DM9DXHM RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=32 DM4T2R3 DI DM4T2R3 DM4T2R3 DN RPR260243 DM4T2R3 MI TTQ6VDM DM4T2R3 MN Voltage-gated potassium channel Kv11.1 (KCNH2) DM4T2R3 MT DTT DM4T2R3 MA Activator DM4T2R3 RN Discovery of a small molecule activator of the human ether-a-go-go-related gene (HERG) cardiac K+ channel. Mol Pharmacol. 2005 Mar;67(3):827-36. DM4T2R3 RU https://pubmed.ncbi.nlm.nih.gov/15548764 DM4LTE3 DI DM4LTE3 DM4LTE3 DN R-PSOP DM4LTE3 MI TT2L6C5 DM4LTE3 MN Neuromedin-U receptor 2 (NMUR2) DM4LTE3 MT DTT DM4LTE3 MA Antagonist DM4LTE3 RN Discovery and pharmacological characterization of a small-molecule antagonist at neuromedin U receptor NMUR2. J Pharmacol Exp Ther. 2009 Jul;330(1):268-75. DM4LTE3 RU https://pubmed.ncbi.nlm.nih.gov/19369576 DMP9V7U DI DMP9V7U DMP9V7U DN RQ-00000008 DMP9V7U MI TT79WV3 DMP9V7U MN Prostaglandin E2 receptor EP4 (PTGER4) DMP9V7U MT DTT DMP9V7U MA Antagonist DMP9V7U RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 343). DMP9V7U RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=343 DMLN280 DI DMLN280 DMLN280 DN RQ-00000010 DMLN280 MI TT07C3Y DMLN280 MN 5-HT 4 receptor (HTR4) DMLN280 MT DTT DMLN280 MA Agonist DMLN280 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 9). DMLN280 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=9 DM4T8KV DI DM4T8KV DM4T8KV DN RQ-00201894 DM4T8KV MI TT953CX DM4T8KV MN Motilin receptor (MLNR) DM4T8KV MT DTT DM4T8KV MA Agonist DM4T8KV RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 297). DM4T8KV RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=297 DMTD3O8 DI DMTD3O8 DMTD3O8 DN RQ-00202730 DMTD3O8 MI TTMSFAW DMTD3O8 MN Cannabinoid receptor 2 (CB2) DMTD3O8 MT DTT DMTD3O8 MA Agonist DMTD3O8 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 57). DMTD3O8 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=57 DMAIOQB DI DMAIOQB DMAIOQB DN RQ-00203066 DMAIOQB MI TTAXZ0K DMAIOQB MN Voltage-gated sodium channel alpha Nav1.3 (SCN3A) DMAIOQB MT DTT DMAIOQB MA Antagonist DMAIOQB RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 580). DMAIOQB RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=580 DM83THZ DI DM83THZ DM83THZ DN RQ-00203078 DM83THZ MI TTXDKTO DM83THZ MN Long transient receptor potential channel 8 (TRPM8) DM83THZ MT DTT DM83THZ MA Antagonist DM83THZ RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 500). DM83THZ RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=500 DMYK6OU DI DMYK6OU DMYK6OU DN RQ-00310941 DMYK6OU MI TT0K1SC DMYK6OU MN 5-HT 2B receptor (HTR2B) DMYK6OU MT DTT DMYK6OU MA Antagonist DMYK6OU RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 7). DMYK6OU RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=7 DMP9RLE DI DMP9RLE DMP9RLE DN RR(17)PZ DMP9RLE MI TTZ9SOR DMP9RLE MN Muscarinic acetylcholine receptor M1 (CHRM1) DMP9RLE MT DTT DMP9RLE MA Inhibitor DMP9RLE RN On the use of nonfluorescent dye labeled ligands in FRET-based receptor binding studies. J Med Chem. 2005 Dec 1;48(24):7847-59. DMP9RLE RU https://pubmed.ncbi.nlm.nih.gov/16302823 DM32ZIC DI DM32ZIC DM32ZIC DN RS 100235 DM32ZIC MI TT07C3Y DM32ZIC MN 5-HT 4 receptor (HTR4) DM32ZIC MT DTT DM32ZIC MA Antagonist DM32ZIC RN New insights into the human 5-HT4 receptor binding site: exploration of a hydrophobic pocket. Br J Pharmacol. 2004 Oct;143(3):361-70. DM32ZIC RU https://pubmed.ncbi.nlm.nih.gov/15351779 DMX9W0T DI DMX9W0T DMX9W0T DN RS 116 0086 DMX9W0T MI TT07C3Y DMX9W0T MN 5-HT 4 receptor (HTR4) DMX9W0T MT DTT DMX9W0T MA Antagonist DMX9W0T RN A 5-HT4 receptor transmembrane network implicated in the activity of inverse agonists but not agonists. J Biol Chem. 2002 Jul 12;277(28):25502-11. DMX9W0T RU https://pubmed.ncbi.nlm.nih.gov/11976337 DMD91WS DI DMD91WS DMD91WS DN RS 57639 DMD91WS MI TT07C3Y DMD91WS MN 5-HT 4 receptor (HTR4) DMD91WS MT DTT DMD91WS MA Agonist DMD91WS RN [3H]RS 57639, a high affinity, selective 5-HT4 receptor partial agonist, specifically labels guinea-pig striatal and rat cloned (5-HT4S and 5-HT4L) receptors. Neuropharmacology. 1997 Apr-May;36(4-5):671-9. DMD91WS RU https://pubmed.ncbi.nlm.nih.gov/9225293 DMO7G94 DI DMO7G94 DMO7G94 DN RS 67333 DMO7G94 MI TT07C3Y DMO7G94 MN 5-HT 4 receptor (HTR4) DMO7G94 MT DTT DMO7G94 MA Agonist DMO7G94 RN Pharmacological characterization of the human 5-HT(4(d)) receptor splice variant stably expressed in Chinese hamster ovary cells. Br J Pharmacol. 2000 Oct;131(4):827-35. DMO7G94 RU https://pubmed.ncbi.nlm.nih.gov/11030734 DM8SGTQ DI DM8SGTQ DM8SGTQ DN RS 93520 DM8SGTQ MI TTNVEIR DM8SGTQ MN Prostaglandin D2 receptor (PTGDR) DM8SGTQ MT DTT DM8SGTQ MA Agonist DM8SGTQ RN Affinities, selectivities, potencies, and intrinsic activities of natural and synthetic prostanoids using endogenous receptors: focus on DP class prostanoids. J Pharmacol Exp Ther. 2000 May;293(2):321-8. DM8SGTQ RU https://pubmed.ncbi.nlm.nih.gov/10772998 DM63NGW DI DM63NGW DM63NGW DN RS-100302 DM63NGW MI TTW0CMT DM63NGW MN Voltage-gated potassium channel Kv1.5 (KCNA5) DM63NGW MT DTT DM63NGW MA Blocker DM63NGW RN New antiarrhythmic agents for atrial fibrillation and atrial flutter. Expert Opin Emerg Drugs. 2005 May;10(2):311-22. DM63NGW RU https://pubmed.ncbi.nlm.nih.gov/15934869 DMDKC0J DI DMDKC0J DMDKC0J DN RS-100329 DMDKC0J MI TTNGILX DMDKC0J MN Adrenergic receptor alpha-1A (ADRA1A) DMDKC0J MT DTT DMDKC0J MA Inhibitor DMDKC0J RN Pharmacophore identification of alpha(1A)-adrenoceptor antagonists. Bioorg Med Chem Lett. 2005 Feb 1;15(3):657-64. DMDKC0J RU https://pubmed.ncbi.nlm.nih.gov/15664832 DMHDYBN DI DMHDYBN DMHDYBN DN RS-102,221 DMHDYBN MI TTWJBZ5 DMHDYBN MN 5-HT 2C receptor (HTR2C) DMHDYBN MT DTT DMHDYBN MA Inhibitor DMHDYBN RN cis-4-(Piperazin-1-yl)-5,6,7a,8,9,10,11,11a-octahydrobenzofuro[2,3-h]quinazolin-2-amine (A-987306), a new histamine H4R antagonist that blocks pain... J Med Chem. 2008 Nov 27;51(22):7094-8. DMHDYBN RU https://pubmed.ncbi.nlm.nih.gov/18983139 DMF71B3 DI DMF71B3 DMF71B3 DN RS-102895 DMF71B3 MI TTFZYTO DMF71B3 MN C-C chemokine receptor type 2 (CCR2) DMF71B3 MT DTT DMF71B3 MA Antagonist DMF71B3 RN Identification of the binding site for a novel class of CCR2b chemokine receptor antagonists: binding to a common chemokine receptor motif within t... J Biol Chem. 2000 Aug 18;275(33):25562-71. DMF71B3 RU https://pubmed.ncbi.nlm.nih.gov/10770925 DMEHN2L DI DMEHN2L DMEHN2L DN RS-136270 DMEHN2L MI TTFZYTO DMEHN2L MN C-C chemokine receptor type 2 (CCR2) DMEHN2L MT DTT DMEHN2L MA Antagonist DMEHN2L RN Identification of the binding site for a novel class of CCR2b chemokine receptor antagonists: binding to a common chemokine receptor motif within t... J Biol Chem. 2000 Aug 18;275(33):25562-71. DMEHN2L RU https://pubmed.ncbi.nlm.nih.gov/10770925 DMRW57G DI DMRW57G DMRW57G DN RS-14491 DMRW57G MI TTZ97H5 DMRW57G MN Phosphodiesterase 4A (PDE4A) DMRW57G MT DTT DMRW57G MA Inhibitor DMRW57G RN Novel heterocyclic-fused pyridazinones as potent and selective phosphodiesterase IV inhibitors. J Med Chem. 1997 May 9;40(10):1417-21. DMRW57G RU https://pubmed.ncbi.nlm.nih.gov/9154964 DMRW57G DI DMRW57G DMRW57G DN RS-14491 DMRW57G MI TTVIAT9 DMRW57G MN Phosphodiesterase 4B (PDE4B) DMRW57G MT DTT DMRW57G MA Inhibitor DMRW57G RN Novel heterocyclic-fused pyridazinones as potent and selective phosphodiesterase IV inhibitors. J Med Chem. 1997 May 9;40(10):1417-21. DMRW57G RU https://pubmed.ncbi.nlm.nih.gov/9154964 DMKQT1Y DI DMKQT1Y DMKQT1Y DN RS-1636 DMKQT1Y MI TTGP7BY DMKQT1Y MN Monoamine oxidase type B (MAO-B) DMKQT1Y MT DTT DMKQT1Y MA Inhibitor DMKQT1Y RN Novel monoamine oxidase inhibitors, 3-(2-aminoethoxy)-1,2-benzisoxazole derivatives, and their differential reversibility. Jpn J Pharmacol. 2002 Feb;88(2):174-82. DMKQT1Y RU https://pubmed.ncbi.nlm.nih.gov/11928718 DM9D8XC DI DM9D8XC DM9D8XC DN RS-1748 DM9D8XC MI TT7HQD0 DM9D8XC MN C-C chemokine receptor type 4 (CCR4) DM9D8XC MT DTT DM9D8XC MA Modulator DM9D8XC RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 61). DM9D8XC RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=61 DM0W2IS DI DM0W2IS DM0W2IS DN RS-25344 DM0W2IS MI TTZ97H5 DM0W2IS MN Phosphodiesterase 4A (PDE4A) DM0W2IS MT DTT DM0W2IS MA Inhibitor DM0W2IS RN Comparison of recombinant human PDE4 isoforms: interaction with substrate and inhibitors. Cell Signal. 1998 Jun;10(6):427-40. DM0W2IS RU https://pubmed.ncbi.nlm.nih.gov/9720765 DM0W2IS DI DM0W2IS DM0W2IS DN RS-25344 DM0W2IS MI TTVIAT9 DM0W2IS MN Phosphodiesterase 4B (PDE4B) DM0W2IS MT DTT DM0W2IS MA Inhibitor DM0W2IS RN Comparison of recombinant human PDE4 isoforms: interaction with substrate and inhibitors. Cell Signal. 1998 Jun;10(6):427-40. DM0W2IS RU https://pubmed.ncbi.nlm.nih.gov/9720765 DM0W2IS DI DM0W2IS DM0W2IS DN RS-25344 DM0W2IS MI TT6A59G DM0W2IS MN Phosphodiesterase 4C (PDE4C) DM0W2IS MT DTT DM0W2IS MA Inhibitor DM0W2IS RN Comparison of recombinant human PDE4 isoforms: interaction with substrate and inhibitors. Cell Signal. 1998 Jun;10(6):427-40. DM0W2IS RU https://pubmed.ncbi.nlm.nih.gov/9720765 DM0W2IS DI DM0W2IS DM0W2IS DN RS-25344 DM0W2IS MI TTSKMI8 DM0W2IS MN Phosphodiesterase 4D (PDE4D) DM0W2IS MT DTT DM0W2IS MA Inhibitor DM0W2IS RN Comparison of recombinant human PDE4 isoforms: interaction with substrate and inhibitors. Cell Signal. 1998 Jun;10(6):427-40. DM0W2IS RU https://pubmed.ncbi.nlm.nih.gov/9720765 DMDC1B4 DI DMDC1B4 DMDC1B4 DN RS-30199 DMDC1B4 MI TTSQIFT DMDC1B4 MN 5-HT 1A receptor (HTR1A) DMDC1B4 MT DTT DMDC1B4 MA Modulator (allosteric modulator) DMDC1B4 RN Interaction of the anxiogenic agent, RS-30199, with 5-HT1A receptors: modulation of sexual activity in the male rat. Neuropharmacology. 1998 Jun;37(6):769-80. DMDC1B4 RU https://pubmed.ncbi.nlm.nih.gov/9707291 DM2SCM7 DI DM2SCM7 DM2SCM7 DN RS-39066 DM2SCM7 MI TTMX39J DM2SCM7 MN Matrix metalloproteinase-1 (MMP-1) DM2SCM7 MT DTT DM2SCM7 MA Inhibitor DM2SCM7 RN Design, synthesis, activity, and structure of a novel class of matrix metalloproteinase inhibitors containing a heterocyclic P2 P3 Bioorg. Med. Chem. Lett. 6(13):1541-1542 (1996). DM2SCM7 RU http://www.sciencedirect.com/science/article/pii/S0960894X96002831 DM2SCM7 DI DM2SCM7 DM2SCM7 DN RS-39066 DM2SCM7 MI TTUZ2L5 DM2SCM7 MN Matrix metalloproteinase-3 (MMP-3) DM2SCM7 MT DTT DM2SCM7 MA Inhibitor DM2SCM7 RN Design, synthesis, activity, and structure of a novel class of matrix metalloproteinase inhibitors containing a heterocyclic P2 P3 Bioorg. Med. Chem. Lett. 6(13):1541-1542 (1996). DM2SCM7 RU http://www.sciencedirect.com/science/article/pii/S0960894X96002831 DM2SCM7 DI DM2SCM7 DM2SCM7 DN RS-39066 DM2SCM7 MI TTMTWOS DM2SCM7 MN Matrix metalloproteinase-7 (MMP-7) DM2SCM7 MT DTT DM2SCM7 MA Inhibitor DM2SCM7 RN Design, synthesis, activity, and structure of a novel class of matrix metalloproteinase inhibitors containing a heterocyclic P2 P3 Bioorg. Med. Chem. Lett. 6(13):1541-1542 (1996). DM2SCM7 RU http://www.sciencedirect.com/science/article/pii/S0960894X96002831 DMLI5U2 DI DMLI5U2 DMLI5U2 DN RS-513815 DMLI5U2 MI TTNGILX DMLI5U2 MN Adrenergic receptor alpha-1A (ADRA1A) DMLI5U2 MT DTT DMLI5U2 MA Inhibitor DMLI5U2 RN Pharmacophore identification of alpha(1A)-adrenoceptor antagonists. Bioorg Med Chem Lett. 2005 Feb 1;15(3):657-64. DMLI5U2 RU https://pubmed.ncbi.nlm.nih.gov/15664832 DM89I0L DI DM89I0L DM89I0L DN RS67506 DM89I0L MI TT07C3Y DM89I0L MN 5-HT 4 receptor (HTR4) DM89I0L MT DTT DM89I0L MA Agonist DM89I0L RN Peripheral 5-HT4 receptors. FASEB J. 1996 Oct;10(12):1398-407. DM89I0L RU https://pubmed.ncbi.nlm.nih.gov/8903510 DMN3ZOD DI DMN3ZOD DMN3ZOD DN RS-PPCC DMN3ZOD MI TTTPE1L DMN3ZOD MN HUMAN opioid receptor sigma 1 (OPRS1) DMN3ZOD MT DTT DMN3ZOD MA Agonist DMN3ZOD RN A SARS-CoV-2 protein interaction map reveals targets for drug repurposing DMN3ZOD RU https://www.nature.com/articles/s41586-020-2286-9 DMWDXPN DI DMWDXPN DMWDXPN DN rT3 DMWDXPN MI TTTSEPU DMWDXPN MN Thyroid hormone receptor alpha (THRA) DMWDXPN MT DTT DMWDXPN MA Agonist DMWDXPN RN Binding of 3,5,3'-triiodothyronine (T3) and its analogs to the in vitro translational products of c-erbA protooncogenes: differences in the affinity of the alpha- and beta-forms for the acetic acid analog and failure of the human testis and kidney alpha-2 products to bind T3. Mol Endocrinol. 1990 Feb;4(2):227-34. DMWDXPN RU https://pubmed.ncbi.nlm.nih.gov/2158622 DMWDXPN DI DMWDXPN DMWDXPN DN rT3 DMWDXPN MI TTGER3L DMWDXPN MN Thyroid hormone receptor beta (THRB) DMWDXPN MT DTT DMWDXPN MA Agonist DMWDXPN RN Binding of 3,5,3'-triiodothyronine (T3) and its analogs to the in vitro translational products of c-erbA protooncogenes: differences in the affinity of the alpha- and beta-forms for the acetic acid analog and failure of the human testis and kidney alpha-2 products to bind T3. Mol Endocrinol. 1990 Feb;4(2):227-34. DMWDXPN RU https://pubmed.ncbi.nlm.nih.gov/2158622 DMLY4C9 DI DMLY4C9 DMLY4C9 DN RTA-301 DMLY4C9 MI TTYFKSZ DMLY4C9 MN Tubulin beta (TUBB) DMLY4C9 MT DTT DMLY4C9 MA Inhibitor DMLY4C9 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2640). DMLY4C9 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2640 DMD3ST8 DI DMD3ST8 DMD3ST8 DN RTI-20 DMD3ST8 MI TT84ETX DMD3ST8 MN Human immunodeficiency virus Reverse transcriptase (HIV RT) DMD3ST8 MT DTT DMD3ST8 MA Inhibitor DMD3ST8 RN Novel non-nucleoside inhibitors of HIV-1 reverse transcriptase. 1. Tricyclic pyridobenzo- and dipyridodiazepinones. J Med Chem. 1991 Jul;34(7):2231-41. DMD3ST8 RU https://pubmed.ncbi.nlm.nih.gov/1712395 DM2QYXN DI DM2QYXN DM2QYXN DN RTI-219 DM2QYXN MI TTVBI8W DM2QYXN MN Dopamine transporter (DAT) DM2QYXN MT DTT DM2QYXN MA Inhibitor DM2QYXN RN Synthesis, monoamine transporter binding, properties, and functional monoamine uptake activity of 3beta-[4-methylphenyl and 4-chlorophenyl]-2 beta-... J Med Chem. 2007 Jul 26;50(15):3686-95. DM2QYXN RU https://pubmed.ncbi.nlm.nih.gov/17602602 DM2QYXN DI DM2QYXN DM2QYXN DN RTI-219 DM2QYXN MI TTAWNKZ DM2QYXN MN Norepinephrine transporter (NET) DM2QYXN MT DTT DM2QYXN MA Inhibitor DM2QYXN RN Synthesis, monoamine transporter binding, properties, and functional monoamine uptake activity of 3beta-[4-methylphenyl and 4-chlorophenyl]-2 beta-... J Med Chem. 2007 Jul 26;50(15):3686-95. DM2QYXN RU https://pubmed.ncbi.nlm.nih.gov/17602602 DM2QYXN DI DM2QYXN DM2QYXN DN RTI-219 DM2QYXN MI TT3ROYC DM2QYXN MN Serotonin transporter (SERT) DM2QYXN MT DTT DM2QYXN MA Inhibitor DM2QYXN RN Synthesis, monoamine transporter binding, properties, and functional monoamine uptake activity of 3beta-[4-methylphenyl and 4-chlorophenyl]-2 beta-... J Med Chem. 2007 Jul 26;50(15):3686-95. DM2QYXN RU https://pubmed.ncbi.nlm.nih.gov/17602602 DMG6TOA DI DMG6TOA DMG6TOA DN RTI-4229-982 DMG6TOA MI TTHS256 DMG6TOA MN Metabotropic glutamate receptor 5 (mGluR5) DMG6TOA MT DTT DMG6TOA MA Antagonist DMG6TOA RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 293). DMG6TOA RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=293 DMR4TM1 DI DMR4TM1 DMR4TM1 DN RTI-5989-23 DMR4TM1 MI TT27RFC DMR4TM1 MN Opioid receptor delta (OPRD1) DMR4TM1 MT DTT DMR4TM1 MA Inhibitor DMR4TM1 RN Investigation of the N-substituent conformation governing potency and mu receptor subtype-selectivity in (+)-(3R, 4R)-dimethyl-4-(3-hydroxyphenyl)p... J Med Chem. 1998 May 21;41(11):1980-90. DMR4TM1 RU https://pubmed.ncbi.nlm.nih.gov/9599247 DMR4TM1 DI DMR4TM1 DMR4TM1 DN RTI-5989-23 DMR4TM1 MI TTQW87Y DMR4TM1 MN Opioid receptor kappa (OPRK1) DMR4TM1 MT DTT DMR4TM1 MA Inhibitor DMR4TM1 RN Investigation of the N-substituent conformation governing potency and mu receptor subtype-selectivity in (+)-(3R, 4R)-dimethyl-4-(3-hydroxyphenyl)p... J Med Chem. 1998 May 21;41(11):1980-90. DMR4TM1 RU https://pubmed.ncbi.nlm.nih.gov/9599247 DMQ28L9 DI DMQ28L9 DMQ28L9 DN RTI-5989-25 DMQ28L9 MI TT27RFC DMQ28L9 MN Opioid receptor delta (OPRD1) DMQ28L9 MT DTT DMQ28L9 MA Inhibitor DMQ28L9 RN Investigation of the N-substituent conformation governing potency and mu receptor subtype-selectivity in (+)-(3R, 4R)-dimethyl-4-(3-hydroxyphenyl)p... J Med Chem. 1998 May 21;41(11):1980-90. DMQ28L9 RU https://pubmed.ncbi.nlm.nih.gov/9599247 DMQ28L9 DI DMQ28L9 DMQ28L9 DN RTI-5989-25 DMQ28L9 MI TTQW87Y DMQ28L9 MN Opioid receptor kappa (OPRK1) DMQ28L9 MT DTT DMQ28L9 MA Inhibitor DMQ28L9 RN Investigation of the N-substituent conformation governing potency and mu receptor subtype-selectivity in (+)-(3R, 4R)-dimethyl-4-(3-hydroxyphenyl)p... J Med Chem. 1998 May 21;41(11):1980-90. DMQ28L9 RU https://pubmed.ncbi.nlm.nih.gov/9599247 DMZO1QC DI DMZO1QC DMZO1QC DN RTI-5989-31 DMZO1QC MI TT27RFC DMZO1QC MN Opioid receptor delta (OPRD1) DMZO1QC MT DTT DMZO1QC MA Inhibitor DMZO1QC RN Probes for narcotic receptor mediated phenomena. 34. Synthesis and structure-activity relationships of a potent mu-agonist delta-antagonist and an ... J Med Chem. 2007 Aug 9;50(16):3765-76. DMZO1QC RU https://pubmed.ncbi.nlm.nih.gov/17625813 DMZO1QC DI DMZO1QC DMZO1QC DN RTI-5989-31 DMZO1QC MI TTQW87Y DMZO1QC MN Opioid receptor kappa (OPRK1) DMZO1QC MT DTT DMZO1QC MA Inhibitor DMZO1QC RN Probes for narcotic receptor mediated phenomena. 34. Synthesis and structure-activity relationships of a potent mu-agonist delta-antagonist and an ... J Med Chem. 2007 Aug 9;50(16):3765-76. DMZO1QC RU https://pubmed.ncbi.nlm.nih.gov/17625813 DMZO1QC DI DMZO1QC DMZO1QC DN RTI-5989-31 DMZO1QC MI TTKWM86 DMZO1QC MN Opioid receptor mu (MOP) DMZO1QC MT DTT DMZO1QC MA Inhibitor DMZO1QC RN Probes for narcotic receptor mediated phenomena. 34. Synthesis and structure-activity relationships of a potent mu-agonist delta-antagonist and an ... J Med Chem. 2007 Aug 9;50(16):3765-76. DMZO1QC RU https://pubmed.ncbi.nlm.nih.gov/17625813 DMWVBD9 DI DMWVBD9 DMWVBD9 DN RTU-1096 DMWVBD9 MI TT7HC21 DMWVBD9 MN Membrane copper amine oxidase (AOC3) DMWVBD9 MT DTT DMWVBD9 MA Inhibitor DMWVBD9 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2767). DMWVBD9 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2767 DMA7URH DI DMA7URH DMA7URH DN RU26988 DMA7URH MI TTOZRK6 DMA7URH MN Glucocorticoid receptor messenger RNA (GCR mRNA) DMA7URH MT DTT DMA7URH MA Agonist DMA7URH RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 625). DMA7URH RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=625 DMN049T DI DMN049T DMN049T DN RU28318 DMN049T MI TT26PHO DMN049T MN Mineralocorticoid receptor (MR) DMN049T MT DTT DMN049T MA Antagonist DMN049T RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 626). DMN049T RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=626 DMAOJ0E DI DMAOJ0E DMAOJ0E DN RU28362 DMAOJ0E MI TTOZRK6 DMAOJ0E MN Glucocorticoid receptor messenger RNA (GCR mRNA) DMAOJ0E MT DTT DMAOJ0E MA Agonist DMAOJ0E RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 625). DMAOJ0E RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=625 DMY9P85 DI DMY9P85 DMY9P85 DN RU-43044 DMY9P85 MI TTKPW01 DMY9P85 MN Androgen receptor messenger RNA (AR mRNA) DMY9P85 MT DTT DMY9P85 MA Inhibitor DMY9P85 RN Discovery of potent, nonsteroidal, and highly selective glucocorticoid receptor antagonists. J Med Chem. 2002 Jun 6;45(12):2417-24. DMY9P85 RU https://pubmed.ncbi.nlm.nih.gov/12036351 DMY9P85 DI DMY9P85 DMY9P85 DN RU-43044 DMY9P85 MI TTOZRK6 DMY9P85 MN Glucocorticoid receptor messenger RNA (GCR mRNA) DMY9P85 MT DTT DMY9P85 MA Inhibitor DMY9P85 RN Virtual screening for the identification of novel nonsteroidal glucocorticoid modulators. J Med Chem. 2010 Apr 22;53(8):3065-74. DMY9P85 RU https://pubmed.ncbi.nlm.nih.gov/20334371 DMCASRD DI DMCASRD DMCASRD DN RU-5135 DMCASRD MI TTGXH6N DMCASRD MN GABA(A) receptor delta (GABRD) DMCASRD MT DTT DMCASRD MA Modulator DMCASRD RN Complex interactions between the steroid derivative RU 5135 and the GABAA-receptor complex. Eur J Pharmacol. 1992 Oct 1;227(2):147-51. DMCASRD RU https://www.ncbi.nlm.nih.gov/pubmed/1330646 DMO3WEG DI DMO3WEG DMO3WEG DN RU-56187 DMO3WEG MI TTKPW01 DMO3WEG MN Androgen receptor messenger RNA (AR mRNA) DMO3WEG MT DTT DMO3WEG MA Inhibitor DMO3WEG RN Structure-activity relationships of bioisosteric replacement of the carboxylic acid in novel androgen receptor pure antagonists. Bioorg Med Chem. 2010 May 1;18(9):3159-68. DMO3WEG RU https://pubmed.ncbi.nlm.nih.gov/20381361 DM5D9UT DI DM5D9UT DM5D9UT DN RU-59063 DM5D9UT MI TTS64P2 DM5D9UT MN Androgen receptor (AR) DM5D9UT MT DTT DM5D9UT MA Inhibitor DM5D9UT RN Design, synthesis, and pharmacological characterization of 4-[4, 4-dimethyl-3-(4-hydroxybutyl)-5-oxo-2-thioxo-1-imidazolidinyl]- 2-iodobenzonitrile... J Med Chem. 2000 Aug 24;43(17):3344-7. DM5D9UT RU https://pubmed.ncbi.nlm.nih.gov/10966753 DMOQE91 DI DMOQE91 DMOQE91 DN RU78191 DMOQE91 MI TT6PKBN DMOQE91 MN Proto-oncogene c-Src (SRC) DMOQE91 MT DTT DMOQE91 MA Inhibitor DMOQE91 RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DMOQE91 RU https://pubmed.ncbi.nlm.nih.gov/10592235 DMR8I03 DI DMR8I03 DMR8I03 DN RU78262 DMR8I03 MI TT6PKBN DMR8I03 MN Proto-oncogene c-Src (SRC) DMR8I03 MT DTT DMR8I03 MA Inhibitor DMR8I03 RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DMR8I03 RU https://pubmed.ncbi.nlm.nih.gov/10592235 DMXAK92 DI DMXAK92 DMXAK92 DN RU78299 DMXAK92 MI TT6PKBN DMXAK92 MN Proto-oncogene c-Src (SRC) DMXAK92 MT DTT DMXAK92 MA Inhibitor DMXAK92 RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DMXAK92 RU https://pubmed.ncbi.nlm.nih.gov/10592235 DM27BKD DI DM27BKD DM27BKD DN RU78300 DM27BKD MI TT6PKBN DM27BKD MN Proto-oncogene c-Src (SRC) DM27BKD MT DTT DM27BKD MA Inhibitor DM27BKD RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DM27BKD RU https://pubmed.ncbi.nlm.nih.gov/10592235 DMU5H4K DI DMU5H4K DMU5H4K DN RU78783 DMU5H4K MI TT6PKBN DMU5H4K MN Proto-oncogene c-Src (SRC) DMU5H4K MT DTT DMU5H4K MA Inhibitor DMU5H4K RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMU5H4K RU https://pubmed.ncbi.nlm.nih.gov/17139284 DM9GQP0 DI DM9GQP0 DM9GQP0 DN RU79072 DM9GQP0 MI TT6PKBN DM9GQP0 MN Proto-oncogene c-Src (SRC) DM9GQP0 MT DTT DM9GQP0 MA Inhibitor DM9GQP0 RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DM9GQP0 RU https://pubmed.ncbi.nlm.nih.gov/10592235 DMWKTYC DI DMWKTYC DMWKTYC DN RU79073 DMWKTYC MI TT6PKBN DMWKTYC MN Proto-oncogene c-Src (SRC) DMWKTYC MT DTT DMWKTYC MA Inhibitor DMWKTYC RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DMWKTYC RU https://pubmed.ncbi.nlm.nih.gov/10592235 DM06BGV DI DM06BGV DM06BGV DN RU79256 DM06BGV MI TT6PKBN DM06BGV MN Proto-oncogene c-Src (SRC) DM06BGV MT DTT DM06BGV MA Inhibitor DM06BGV RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DM06BGV RU https://pubmed.ncbi.nlm.nih.gov/10592235 DMY3X6I DI DMY3X6I DMY3X6I DN RU81843 DMY3X6I MI TT6PKBN DMY3X6I MN Proto-oncogene c-Src (SRC) DMY3X6I MT DTT DMY3X6I MA Inhibitor DMY3X6I RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMY3X6I RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMX7ZI0 DI DMX7ZI0 DMX7ZI0 DN RU82129 DMX7ZI0 MI TT6PKBN DMX7ZI0 MN Proto-oncogene c-Src (SRC) DMX7ZI0 MT DTT DMX7ZI0 MA Inhibitor DMX7ZI0 RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMX7ZI0 RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMJG4RC DI DMJG4RC DMJG4RC DN RU82197 DMJG4RC MI TT6PKBN DMJG4RC MN Proto-oncogene c-Src (SRC) DMJG4RC MT DTT DMJG4RC MA Inhibitor DMJG4RC RN DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Nucleic Acids Res. 2011 Jan;39(Database issue):D1035-41. DMJG4RC RU https://pubmed.ncbi.nlm.nih.gov/21059682 DMR3A2O DI DMR3A2O DMR3A2O DN RU82209 DMR3A2O MI TT6PKBN DMR3A2O MN Proto-oncogene c-Src (SRC) DMR3A2O MT DTT DMR3A2O MA Inhibitor DMR3A2O RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMR3A2O RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMNGKYF DI DMNGKYF DMNGKYF DN RU83876 DMNGKYF MI TT6PKBN DMNGKYF MN Proto-oncogene c-Src (SRC) DMNGKYF MT DTT DMNGKYF MA Inhibitor DMNGKYF RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMNGKYF RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMWK3LU DI DMWK3LU DMWK3LU DN RU84687 DMWK3LU MI TT6PKBN DMWK3LU MN Proto-oncogene c-Src (SRC) DMWK3LU MT DTT DMWK3LU MA Inhibitor DMWK3LU RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DMWK3LU RU https://pubmed.ncbi.nlm.nih.gov/10592235 DMOA8FK DI DMOA8FK DMOA8FK DN RU85053 DMOA8FK MI TT6PKBN DMOA8FK MN Proto-oncogene c-Src (SRC) DMOA8FK MT DTT DMOA8FK MA Inhibitor DMOA8FK RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMOA8FK RU https://pubmed.ncbi.nlm.nih.gov/17139284 DM97ZHX DI DM97ZHX DM97ZHX DN RU85493 DM97ZHX MI TT6PKBN DM97ZHX MN Proto-oncogene c-Src (SRC) DM97ZHX MT DTT DM97ZHX MA Inhibitor DM97ZHX RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DM97ZHX RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMHFKUC DI DMHFKUC DMHFKUC DN RU90395 DMHFKUC MI TT6PKBN DMHFKUC MN Proto-oncogene c-Src (SRC) DMHFKUC MT DTT DMHFKUC MA Inhibitor DMHFKUC RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMHFKUC RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMOHTC6 DI DMOHTC6 DMOHTC6 DN Ruthenium red DMOHTC6 MI TTU5CIX DMOHTC6 MN Ryanodine receptor 1 (RYR1) DMOHTC6 MT DTT DMOHTC6 MA Antagonist DMOHTC6 RN Role of ryanodine receptor channels in Ca2+ oscillations of porcine tracheal smooth muscle. Am J Physiol. 1997 Apr;272(4 Pt 1):L659-64. DMOHTC6 RU https://pubmed.ncbi.nlm.nih.gov/9142939 DMEHRAJ DI DMEHRAJ DMEHRAJ DN Rutin DMEHRAJ MI DEBI82Z DMEHRAJ MN Alpha-L-rhamnosidase (lrA) DMEHRAJ MT DME DMEHRAJ MA Metabolism DMEHRAJ RN Metabolism of rutin and poncirin by human intestinal microbiota and cloning of their metabolizing alpha-L-rhamnosidase from Bifidobacterium dentium. J Microbiol Biotechnol. 2015 Jan;25(1):18-25. DMEHRAJ RU https://pubmed.ncbi.nlm.nih.gov/25179902 DMEHRAJ DI DMEHRAJ DMEHRAJ DN Rutin DMEHRAJ MI DEC389G DMEHRAJ MN Alpha-L-rhamnosidase (lrA) DMEHRAJ MT DME DMEHRAJ MA Metabolism DMEHRAJ RN Identification of rutin deglycosylated metabolites produced by human intestinal bacteria using UPLC-Q-TOF/MS. J Chromatogr B Analyt Technol Biomed Life Sci. 2012 Jun 1;898:95-100. DMEHRAJ RU https://pubmed.ncbi.nlm.nih.gov/22583754 DMEHRAJ DI DMEHRAJ DMEHRAJ DN Rutin DMEHRAJ MI DE7BILX DMEHRAJ MN Alpha-L-rhamnosidase (lrA) DMEHRAJ MT DME DMEHRAJ MA Metabolism DMEHRAJ RN Identification of rutin deglycosylated metabolites produced by human intestinal bacteria using UPLC-Q-TOF/MS. J Chromatogr B Analyt Technol Biomed Life Sci. 2012 Jun 1;898:95-100. DMEHRAJ RU https://pubmed.ncbi.nlm.nih.gov/22583754 DMEHRAJ DI DMEHRAJ DMEHRAJ DN Rutin DMEHRAJ MI DE13AYF DMEHRAJ MN Alpha-L-rhamnosidase (lrA) DMEHRAJ MT DME DMEHRAJ MA Metabolism DMEHRAJ RN Identification of rutin deglycosylated metabolites produced by human intestinal bacteria using UPLC-Q-TOF/MS. J Chromatogr B Analyt Technol Biomed Life Sci. 2012 Jun 1;898:95-100. DMEHRAJ RU https://pubmed.ncbi.nlm.nih.gov/22583754 DMEHRAJ DI DMEHRAJ DMEHRAJ DN Rutin DMEHRAJ MI TT5ZWB6 DMEHRAJ MN Dihydrodiol dehydrogenase type I (AKR1C3) DMEHRAJ MT DTT DMEHRAJ MA Inhibitor DMEHRAJ RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMEHRAJ RU https://pubmed.ncbi.nlm.nih.gov/17139284 DM8EZTM DI DM8EZTM DM8EZTM DN RvD1-ME DM8EZTM MI TTOJ1NF DM8EZTM MN FMLP-related receptor I (FPR2) DM8EZTM MT DTT DM8EZTM MA Agonist DM8EZTM RN Resolvin D1 receptor stereoselectivity and regulation of inflammation and proresolving microRNAs. Am J Pathol. 2012 May;180(5):2018-27. DM8EZTM RU https://pubmed.ncbi.nlm.nih.gov/22449948 DM8EZTM DI DM8EZTM DM8EZTM DN RvD1-ME DM8EZTM MI TT7OCUB DM8EZTM MN G-protein coupled receptor 32 (GPR32) DM8EZTM MT DTT DM8EZTM MA Agonist DM8EZTM RN Resolvin D1 receptor stereoselectivity and regulation of inflammation and proresolving microRNAs. Am J Pathol. 2012 May;180(5):2018-27. DM8EZTM RU https://pubmed.ncbi.nlm.nih.gov/22449948 DMAU6FN DI DMAU6FN DMAU6FN DN RwFwLL-NH2 DMAU6FN MI TTWDC17 DMAU6FN MN Growth hormone secretagogue receptor 1 (GHSR) DMAU6FN MT DTT DMAU6FN MA Inhibitor DMAU6FN RN Identification of an efficacy switch region in the ghrelin receptor responsible for interchange between agonism and inverse agonism. J Biol Chem. 2007 May 25;282(21):15799-811. DMAU6FN RU https://pubmed.ncbi.nlm.nih.gov/17371869 DMP7SI9 DI DMP7SI9 DMP7SI9 DN RWJ-140998 DMP7SI9 MI TTICX3S DMP7SI9 MN Bacterial UDP-N-acetylglucosamine carboxyvinyltransferase (Bact murA) DMP7SI9 MT DTT DMP7SI9 MA Inhibitor DMP7SI9 RN Emerging drugs for bacterial urinary tract infections. Expert Opin Emerg Drugs. 2005 May;10(2):275-98. DMP7SI9 RU https://pubmed.ncbi.nlm.nih.gov/15934867 DME68VT DI DME68VT DME68VT DN RWJ-16979 DME68VT MI TT1MPAY DME68VT MN GABA(A) receptor alpha-1 (GABRA1) DME68VT MT DTT DME68VT MA Inhibitor DME68VT RN Potential anxiolytic agents. Pyrido[1,2-a]benzimidazoles: a new structural class of ligands for the benzodiazepine binding site on GABA-A receptors. J Med Chem. 1995 Jan 6;38(1):16-20. DME68VT RU https://pubmed.ncbi.nlm.nih.gov/7837226 DME68VT DI DME68VT DME68VT DN RWJ-16979 DME68VT MI TTNJYV2 DME68VT MN Gamma-aminobutyric acid receptor (GAR) DME68VT MT DTT DME68VT MA Inhibitor DME68VT RN Potential anxiolytic agents. Pyrido[1,2-a]benzimidazoles: a new structural class of ligands for the benzodiazepine binding site on GABA-A receptors. J Med Chem. 1995 Jan 6;38(1):16-20. DME68VT RU https://pubmed.ncbi.nlm.nih.gov/7837226 DMPJTLM DI DMPJTLM DMPJTLM DN RWJ-38063 DMPJTLM MI TTNGILX DMPJTLM MN Adrenergic receptor alpha-1A (ADRA1A) DMPJTLM MT DTT DMPJTLM MA Inhibitor DMPJTLM RN Pharmacophore identification of alpha(1A)-adrenoceptor antagonists. Bioorg Med Chem Lett. 2005 Feb 1;15(3):657-64. DMPJTLM RU https://pubmed.ncbi.nlm.nih.gov/15664832 DMPJTLM DI DMPJTLM DMPJTLM DN RWJ-38063 DMPJTLM MI TT34BHT DMPJTLM MN Adrenergic receptor alpha-1D (ADRA1D) DMPJTLM MT DTT DMPJTLM MA Inhibitor DMPJTLM RN Novel arylpiperazines as selective alpha1-adrenergic receptor antagonists. Bioorg Med Chem Lett. 2000 May 15;10(10):1093-6. DMPJTLM RU https://pubmed.ncbi.nlm.nih.gov/10843225 DM28IKN DI DM28IKN DM28IKN DN RWJ-387273 DM28IKN MI TTJ0IQB DM28IKN MN Phosphodiesterase 5A (PDE5A) DM28IKN MT DTT DM28IKN MA Modulator DM28IKN RN DOI: 10.1021/op060099f DM28IKN RU http://pubs.acs.org/doi/abs/10.1021/op060099f DMBVLCQ DI DMBVLCQ DMBVLCQ DN RWJ-3981 DMBVLCQ MI TTICX3S DMBVLCQ MN Bacterial UDP-N-acetylglucosamine carboxyvinyltransferase (Bact murA) DMBVLCQ MT DTT DMBVLCQ MA Inhibitor DMBVLCQ RN Emerging drugs for bacterial urinary tract infections. Expert Opin Emerg Drugs. 2005 May;10(2):275-98. DMBVLCQ RU https://pubmed.ncbi.nlm.nih.gov/15934867 DMBOSGN DI DMBOSGN DMBOSGN DN RWJ-49968 DMBOSGN MI TTJVCG0 DMBOSGN MN Bacterial Sporulation kinase A (Bact kinA) DMBOSGN MT DTT DMBOSGN MA Inhibitor DMBOSGN RN Antifungal agents: mode of action in yeast cells. Rev Esp Quimioter. 2006 Jun;19(2):130-9. DMBOSGN RU https://pubmed.ncbi.nlm.nih.gov/16964330 DMRPYGX DI DMRPYGX DMRPYGX DN RWJ-50353 DMRPYGX MI TT2WR1T DMRPYGX MN Cationic trypsinogen (PRSS1) DMRPYGX MT DTT DMRPYGX MA Inhibitor DMRPYGX RN In-depth study of tripeptide-based alpha-ketoheterocycles as inhibitors of thrombin. Effective utilization of the S1' subsite and its implications ... J Med Chem. 2005 Mar 24;48(6):1984-2008. DMRPYGX RU https://pubmed.ncbi.nlm.nih.gov/15771442 DMRPYGX DI DMRPYGX DMRPYGX DN RWJ-50353 DMRPYGX MI TT6L509 DMRPYGX MN Coagulation factor IIa (F2) DMRPYGX MT DTT DMRPYGX MA Inhibitor DMRPYGX RN Inhibitors of proteases and amide hydrolases that employ an alpha-ketoheterocycle as a key enabling functionality. Bioorg Med Chem. 2008 Feb 15;16(4):1562-95. DMRPYGX RU https://pubmed.ncbi.nlm.nih.gov/18053726 DMAEWMP DI DMAEWMP DMAEWMP DN RWJ-53419 DMAEWMP MI TTJA1ZO DMAEWMP MN ITGB3 messenger RNA (ITGB3 mRNA) DMAEWMP MT DTT DMAEWMP MA Inhibitor DMAEWMP RN 1,2,4-triazolo[3,4-a]pyridine as a novel, constrained template for fibrinogen receptor (GPIIb/IIIa) antagonists. Bioorg Med Chem Lett. 2001 Oct 8;11(19):2619-22. DMAEWMP RU https://pubmed.ncbi.nlm.nih.gov/11551763 DME07AN DI DME07AN DME07AN DN RWJ-56110 DME07AN MI TTL935N DME07AN MN Proteinase activated receptor 1 (F2R) DME07AN MT DTT DME07AN MA Antagonist DME07AN RN Design, synthesis, and biological characterization of a peptide-mimetic antagonist for a tethered-ligand receptor. Proc Natl Acad Sci U S A. 1999 Oct 26;96(22):12257-62. DME07AN RU https://pubmed.ncbi.nlm.nih.gov/10535908 DMGUWFJ DI DMGUWFJ DMGUWFJ DN RWJ-61907 DMGUWFJ MI TTJVCG0 DMGUWFJ MN Bacterial Sporulation kinase A (Bact kinA) DMGUWFJ MT DTT DMGUWFJ MA Inhibitor DMGUWFJ RN Antifungal agents: mode of action in yeast cells. Rev Esp Quimioter. 2006 Jun;19(2):130-9. DMGUWFJ RU https://pubmed.ncbi.nlm.nih.gov/16964330 DMUZW80 DI DMUZW80 DMUZW80 DN RWJ-68141 DMUZW80 MI TTNGILX DMUZW80 MN Adrenergic receptor alpha-1A (ADRA1A) DMUZW80 MT DTT DMUZW80 MA Inhibitor DMUZW80 RN Pharmacophore identification of alpha(1A)-adrenoceptor antagonists. Bioorg Med Chem Lett. 2005 Feb 1;15(3):657-64. DMUZW80 RU https://pubmed.ncbi.nlm.nih.gov/15664832 DMUK7LX DI DMUK7LX DMUK7LX DN RWJ-68157 DMUK7LX MI TTNGILX DMUK7LX MN Adrenergic receptor alpha-1A (ADRA1A) DMUK7LX MT DTT DMUK7LX MA Inhibitor DMUK7LX RN Pharmacophore identification of alpha(1A)-adrenoceptor antagonists. Bioorg Med Chem Lett. 2005 Feb 1;15(3):657-64. DMUK7LX RU https://pubmed.ncbi.nlm.nih.gov/15664832 DMUK7LX DI DMUK7LX DMUK7LX DN RWJ-68157 DMUK7LX MI TTBRKXS DMUK7LX MN Adrenergic receptor alpha-1B (ADRA1B) DMUK7LX MT DTT DMUK7LX MA Inhibitor DMUK7LX RN Novel arylpiperazines as selective alpha1-adrenergic receptor antagonists. Bioorg Med Chem Lett. 2000 May 15;10(10):1093-6. DMUK7LX RU https://pubmed.ncbi.nlm.nih.gov/10843225 DMUK7LX DI DMUK7LX DMUK7LX DN RWJ-68157 DMUK7LX MI TT34BHT DMUK7LX MN Adrenergic receptor alpha-1D (ADRA1D) DMUK7LX MT DTT DMUK7LX MA Inhibitor DMUK7LX RN Novel arylpiperazines as selective alpha1-adrenergic receptor antagonists. Bioorg Med Chem Lett. 2000 May 15;10(10):1093-6. DMUK7LX RU https://pubmed.ncbi.nlm.nih.gov/10843225 DMNLVRS DI DMNLVRS DMNLVRS DN RWJ-68354 DMNLVRS MI TTYT93M DMNLVRS MN MAP kinase p38 (MAPK12) DMNLVRS MT DTT DMNLVRS MA Inhibitor DMNLVRS RN Imidazopyrimidines, potent inhibitors of p38 MAP kinase. Bioorg Med Chem Lett. 2003 Feb 10;13(3):347-50. DMNLVRS RU https://pubmed.ncbi.nlm.nih.gov/12565927 DMNLVRS DI DMNLVRS DMNLVRS DN RWJ-68354 DMNLVRS MI TTQBR95 DMNLVRS MN Stress-activated protein kinase 2a (p38 alpha) DMNLVRS MT DTT DMNLVRS MA Inhibitor DMNLVRS RN Imidazopyrimidines, potent inhibitors of p38 MAP kinase. Bioorg Med Chem Lett. 2003 Feb 10;13(3):347-50. DMNLVRS RU https://pubmed.ncbi.nlm.nih.gov/12565927 DMNLVRS DI DMNLVRS DMNLVRS DN RWJ-68354 DMNLVRS MI TT73U6C DMNLVRS MN Stress-activated protein kinase 2b (p38 beta) DMNLVRS MT DTT DMNLVRS MA Inhibitor DMNLVRS RN Imidazopyrimidines, potent inhibitors of p38 MAP kinase. Bioorg Med Chem Lett. 2003 Feb 10;13(3):347-50. DMNLVRS RU https://pubmed.ncbi.nlm.nih.gov/12565927 DM2EOBM DI DM2EOBM DM2EOBM DN RWJ-69736 DM2EOBM MI TTNGILX DM2EOBM MN Adrenergic receptor alpha-1A (ADRA1A) DM2EOBM MT DTT DM2EOBM MA Inhibitor DM2EOBM RN Pharmacophore identification of alpha(1A)-adrenoceptor antagonists. Bioorg Med Chem Lett. 2005 Feb 1;15(3):657-64. DM2EOBM RU https://pubmed.ncbi.nlm.nih.gov/15664832 DM2EOBM DI DM2EOBM DM2EOBM DN RWJ-69736 DM2EOBM MI TTBRKXS DM2EOBM MN Adrenergic receptor alpha-1B (ADRA1B) DM2EOBM MT DTT DM2EOBM MA Inhibitor DM2EOBM RN Novel arylpiperazines as selective alpha1-adrenergic receptor antagonists. Bioorg Med Chem Lett. 2000 May 15;10(10):1093-6. DM2EOBM RU https://pubmed.ncbi.nlm.nih.gov/10843225 DM2EOBM DI DM2EOBM DM2EOBM DN RWJ-69736 DM2EOBM MI TT34BHT DM2EOBM MN Adrenergic receptor alpha-1D (ADRA1D) DM2EOBM MT DTT DM2EOBM MA Inhibitor DM2EOBM RN Novel arylpiperazines as selective alpha1-adrenergic receptor antagonists. Bioorg Med Chem Lett. 2000 May 15;10(10):1093-6. DM2EOBM RU https://pubmed.ncbi.nlm.nih.gov/10843225 DMKYNGE DI DMKYNGE DMKYNGE DN RX-1792 DMKYNGE MI TTGKNB4 DMKYNGE MN Epidermal growth factor receptor (EGFR) DMKYNGE MT DTT DMKYNGE MA Antagonist DMKYNGE RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1797). DMKYNGE RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1797 DMM5O30 DI DMM5O30 DMM5O30 DN RXP-407 DMM5O30 MI TTL69WB DMM5O30 MN Angiotensin-converting enzyme (ACE) DMM5O30 MT DTT DMM5O30 MA Inhibitor DMM5O30 RN New ketomethylene inhibitor analogues: synthesis and assessment of structural determinants for N-domain selective inhibition of angiotensin-converting enzyme. Biol Chem. 2012 May;393(6):485-93. DMM5O30 RU https://pubmed.ncbi.nlm.nih.gov/22628311 DM5GIUY DI DM5GIUY DM5GIUY DN RXP-470 DM5GIUY MI TTXZ0KQ DM5GIUY MN Matrix metalloproteinase-12 (MMP-12) DM5GIUY MT DTT DM5GIUY MA Inhibitor DM5GIUY RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1636). DM5GIUY RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1636 DMB7EGU DI DMB7EGU DMB7EGU DN RXP470.1 DMB7EGU MI TTXZ0KQ DMB7EGU MN Matrix metalloproteinase-12 (MMP-12) DMB7EGU MT DTT DMB7EGU MA Inhibitor DMB7EGU RN Molecular determinants of a selective matrix metalloprotease-12 inhibitor: insights from crystallography and thermodynamic studies. J Med Chem. 2013 Feb 14;56(3):1149-59. DMB7EGU RU https://pubmed.ncbi.nlm.nih.gov/23343195 DM9KXV0 DI DM9KXV0 DM9KXV0 DN RY024 DM9KXV0 MI TTNZPQ1 DM9KXV0 MN GABA(A) receptor alpha-5 (GABRA5) DM9KXV0 MT DTT DM9KXV0 MA Modulator (allosteric modulator) DM9KXV0 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 408). DM9KXV0 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=408 DMGUX16 DI DMGUX16 DMGUX16 DN RY-066 DMGUX16 MI TT1MPAY DMGUX16 MN GABA(A) receptor alpha-1 (GABRA1) DMGUX16 MT DTT DMGUX16 MA Inhibitor DMGUX16 RN Predictive models for GABAA/benzodiazepine receptor subtypes: studies of quantitative structure-activity relationships for imidazobenzodiazepines a... J Med Chem. 1998 Oct 8;41(21):4130-42. DMGUX16 RU https://pubmed.ncbi.nlm.nih.gov/9767648 DMGUX16 DI DMGUX16 DMGUX16 DN RY-066 DMGUX16 MI TTBMV1G DMGUX16 MN GABA(A) receptor alpha-2 (GABRA2) DMGUX16 MT DTT DMGUX16 MA Inhibitor DMGUX16 RN Predictive models for GABAA/benzodiazepine receptor subtypes: studies of quantitative structure-activity relationships for imidazobenzodiazepines a... J Med Chem. 1998 Oct 8;41(21):4130-42. DMGUX16 RU https://pubmed.ncbi.nlm.nih.gov/9767648 DMGUX16 DI DMGUX16 DMGUX16 DN RY-066 DMGUX16 MI TT37EDJ DMGUX16 MN GABA(A) receptor alpha-3 (GABRA3) DMGUX16 MT DTT DMGUX16 MA Inhibitor DMGUX16 RN Predictive models for GABAA/benzodiazepine receptor subtypes: studies of quantitative structure-activity relationships for imidazobenzodiazepines a... J Med Chem. 1998 Oct 8;41(21):4130-42. DMGUX16 RU https://pubmed.ncbi.nlm.nih.gov/9767648 DMGUX16 DI DMGUX16 DMGUX16 DN RY-066 DMGUX16 MI TT06RH5 DMGUX16 MN GABA(A) receptor gamma-2 (GABRG2) DMGUX16 MT DTT DMGUX16 MA Inhibitor DMGUX16 RN Predictive models for GABAA/benzodiazepine receptor subtypes: studies of quantitative structure-activity relationships for imidazobenzodiazepines a... J Med Chem. 1998 Oct 8;41(21):4130-42. DMGUX16 RU https://pubmed.ncbi.nlm.nih.gov/9767648 DMGUX16 DI DMGUX16 DMGUX16 DN RY-066 DMGUX16 MI TTNJYV2 DMGUX16 MN Gamma-aminobutyric acid receptor (GAR) DMGUX16 MT DTT DMGUX16 MA Inhibitor DMGUX16 RN Predictive models for GABAA/benzodiazepine receptor subtypes: studies of quantitative structure-activity relationships for imidazobenzodiazepines a... J Med Chem. 1998 Oct 8;41(21):4130-42. DMGUX16 RU https://pubmed.ncbi.nlm.nih.gov/9767648 DMW4850 DI DMW4850 DMW4850 DN RY796 DMW4850 MI TT5OEKU DMW4850 MN Voltage-gated potassium channel Kv2.1 (KCNB1) DMW4850 MT DTT DMW4850 MA Inhibitor (gating inhibitor) DMW4850 RN Identification of novel and selective Kv2 channel inhibitors. Mol Pharmacol. 2011 Dec;80(6):959-64. DMW4850 RU https://pubmed.ncbi.nlm.nih.gov/21948463 DMW4850 DI DMW4850 DMW4850 DN RY796 DMW4850 MI TT5PFNG DMW4850 MN Voltage-gated potassium channel Kv2.2 (KCNB2) DMW4850 MT DTT DMW4850 MA Inhibitor (gating inhibitor) DMW4850 RN Identification of novel and selective Kv2 channel inhibitors. Mol Pharmacol. 2011 Dec;80(6):959-64. DMW4850 RU https://pubmed.ncbi.nlm.nih.gov/21948463 DM2K6I8 DI DM2K6I8 DM2K6I8 DN Ryanodine DM2K6I8 MI TTU5CIX DM2K6I8 MN Ryanodine receptor 1 (RYR1) DM2K6I8 MT DTT DM2K6I8 MA Antagonist DM2K6I8 RN The contribution of inositol 1,4,5-trisphosphate and ryanodine receptors to agonist-induced Ca(2+) signaling of airway smooth muscle cells. Am J Physiol Lung Cell Mol Physiol. 2009 Aug;297(2):L347-61. DM2K6I8 RU https://pubmed.ncbi.nlm.nih.gov/19465516 DM9HA8G DI DM9HA8G DM9HA8G DN S 0957 DM9HA8G MI TT1KPBZ DM9HA8G MN Glucose-6-phosphate translocase (SLC37A4) DM9HA8G MT DTT DM9HA8G MA Inhibitor DM9HA8G RN Identification of protein components of the microsomal glucose 6-phosphate transporter by photoaffinity labelling. Biochem J. 1999 May 1;339 ( Pt 3):629-38. DM9HA8G RU https://pubmed.ncbi.nlm.nih.gov/10215602 DMA5GOX DI DMA5GOX DMA5GOX DN S 1743 DMA5GOX MI TT1KPBZ DMA5GOX MN Glucose-6-phosphate translocase (SLC37A4) DMA5GOX MT DTT DMA5GOX MA Inhibitor DMA5GOX RN Identification of protein components of the microsomal glucose 6-phosphate transporter by photoaffinity labelling. Biochem J. 1999 May 1;339 ( Pt 3):629-38. DMA5GOX RU https://pubmed.ncbi.nlm.nih.gov/10215602 DM2FC5V DI DM2FC5V DM2FC5V DN S 18204 DM2FC5V MI TT2O84V DM2FC5V MN Thromboxane A2 receptor (TBXA2R) DM2FC5V MT DTT DM2FC5V MA Modulator DM2FC5V RN Antithrombotic effects of S 18886, a novel orally active thromboxane A2 receptor antagonist. J Thromb Haemost. 2004 Mar;2(3):492-8. DM2FC5V RU https://www.ncbi.nlm.nih.gov/pubmed/15009468 DMGEHNX DI DMGEHNX DMGEHNX DN S 202 791 DMGEHNX MI TTXHYV6 DMGEHNX MN Voltage-gated L-type calcium channel (L-CaC) DMGEHNX MT DTT DMGEHNX MA Activator DMGEHNX RN Molecular determinants of drug binding and action on L-type calcium channels. Annu Rev Pharmacol Toxicol. 1997;37:361-96. DMGEHNX RU https://pubmed.ncbi.nlm.nih.gov/9131258 DMZN0RW DI DMZN0RW DMZN0RW DN S 3025 DMZN0RW MI TT1KPBZ DMZN0RW MN Glucose-6-phosphate translocase (SLC37A4) DMZN0RW MT DTT DMZN0RW MA Inhibitor DMZN0RW RN Prolonged blood glucose reduction in mrp-2 deficient rats (GY/TR(-)) by the glucose-6-phosphate translocase inhibitor S 3025. Biochim Biophys Acta. 2002 Jan 15;1569(1-3):105-10. DMZN0RW RU https://pubmed.ncbi.nlm.nih.gov/11853963 DMXUBIK DI DMXUBIK DMXUBIK DN S-(-)CPB DMXUBIK MI TTUYAF3 DMXUBIK MN Chloride channel protein 1 (ClC-1) DMXUBIK MT DTT DMXUBIK MA Blocker (channel blocker) DMXUBIK RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 698). DMXUBIK RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=698 DME9QR0 DI DME9QR0 DME9QR0 DN S-(-)CPP DME9QR0 MI TTUYAF3 DME9QR0 MN Chloride channel protein 1 (ClC-1) DME9QR0 MT DTT DME9QR0 MA Blocker (channel blocker) DME9QR0 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 698). DME9QR0 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=698 DMQG4L2 DI DMQG4L2 DMQG4L2 DN S-(-)-enantiomer of 3-(3-hydroxyphenyl)-N-n-propylpiperidine (3-PPP) DMQG4L2 MI TTV5CGO DMQG4L2 MN Phosphodiesterase 4 (PDE4) DMQG4L2 MT DTT DMQG4L2 MA Inhibitor DMQG4L2 RN Ocular hypotension induced by topical dopaminergic drugs and phosphodiesterase inhibitors. Eur J Pharmacol. 1994 Jun 2;258(1-2):85-94. DMQG4L2 RU https://pubmed.ncbi.nlm.nih.gov/7925603 DM1D7KY DI DM1D7KY DM1D7KY DN S-(-)-sulpiride DM1D7KY MI TTEX248 DM1D7KY MN Dopamine D2 receptor (D2R) DM1D7KY MT DTT DM1D7KY MA Antagonist DM1D7KY RN The treatment of Tourette's syndrome: current opinions. Expert Opin Pharmacother. 2002 Jul;3(7):899-914. DM1D7KY RU https://pubmed.ncbi.nlm.nih.gov/12083990 DMO1R69 DI DMO1R69 DMO1R69 DN S-(2,4-Dichlorobenzyl)isothiourea hydrobromide DMO1R69 MI TTZJYKH DMO1R69 MN Indoleamine 2,3-dioxygenase 1 (IDO1) DMO1R69 MT DTT DMO1R69 MA Inhibitor DMO1R69 RN S-benzylisothiourea derivatives as small-molecule inhibitors of indoleamine-2,3-dioxygenase. Bioorg Med Chem Lett. 2010 Sep 1;20(17):5126-9. DMO1R69 RU https://pubmed.ncbi.nlm.nih.gov/20688518 DMMZQB5 DI DMMZQB5 DMMZQB5 DN S-(2-boronoethyl)-L-cysteine DMMZQB5 MI TTV1AG6 DMMZQB5 MN Kidney-type arginase (ARG2) DMMZQB5 MT DTT DMMZQB5 MA Inhibitor DMMZQB5 RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMMZQB5 RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMN62KP DI DMN62KP DMN62KP DN S-(2-Chlorobenzyl)isothiourea hydrochloride DMN62KP MI TTZJYKH DMN62KP MN Indoleamine 2,3-dioxygenase 1 (IDO1) DMN62KP MT DTT DMN62KP MA Inhibitor DMN62KP RN S-benzylisothiourea derivatives as small-molecule inhibitors of indoleamine-2,3-dioxygenase. Bioorg Med Chem Lett. 2010 Sep 1;20(17):5126-9. DMN62KP RU https://pubmed.ncbi.nlm.nih.gov/20688518 DMNMCQJ DI DMNMCQJ DMNMCQJ DN S-(3,4-Dichlorobenzyl)isothiourea hydrochloride DMNMCQJ MI TTZJYKH DMNMCQJ MN Indoleamine 2,3-dioxygenase 1 (IDO1) DMNMCQJ MT DTT DMNMCQJ MA Inhibitor DMNMCQJ RN S-benzylisothiourea derivatives as small-molecule inhibitors of indoleamine-2,3-dioxygenase. Bioorg Med Chem Lett. 2010 Sep 1;20(17):5126-9. DMNMCQJ RU https://pubmed.ncbi.nlm.nih.gov/20688518 DMNG6JB DI DMNG6JB DMNG6JB DN S-(3-Chlorobenzyl)isothiourea hydrochloride DMNG6JB MI TTZJYKH DMNG6JB MN Indoleamine 2,3-dioxygenase 1 (IDO1) DMNG6JB MT DTT DMNG6JB MA Inhibitor DMNG6JB RN S-benzylisothiourea derivatives as small-molecule inhibitors of indoleamine-2,3-dioxygenase. Bioorg Med Chem Lett. 2010 Sep 1;20(17):5126-9. DMNG6JB RU https://pubmed.ncbi.nlm.nih.gov/20688518 DM0XDFG DI DM0XDFG DM0XDFG DN S-(4-Bromobenzyl)isothiourea hydrobromide DM0XDFG MI TTZJYKH DM0XDFG MN Indoleamine 2,3-dioxygenase 1 (IDO1) DM0XDFG MT DTT DM0XDFG MA Inhibitor DM0XDFG RN S-benzylisothiourea derivatives as small-molecule inhibitors of indoleamine-2,3-dioxygenase. Bioorg Med Chem Lett. 2010 Sep 1;20(17):5126-9. DM0XDFG RU https://pubmed.ncbi.nlm.nih.gov/20688518 DMWJE2X DI DMWJE2X DMWJE2X DN S-(4-Chlorobenzyl)isothiourea hydrochloride DMWJE2X MI TTZJYKH DMWJE2X MN Indoleamine 2,3-dioxygenase 1 (IDO1) DMWJE2X MT DTT DMWJE2X MA Inhibitor DMWJE2X RN S-benzylisothiourea derivatives as small-molecule inhibitors of indoleamine-2,3-dioxygenase. Bioorg Med Chem Lett. 2010 Sep 1;20(17):5126-9. DMWJE2X RU https://pubmed.ncbi.nlm.nih.gov/20688518 DMYGULD DI DMYGULD DMYGULD DN S-(4-Cyanobenzyl)isothiourea hydrobromide DMYGULD MI TTZJYKH DMYGULD MN Indoleamine 2,3-dioxygenase 1 (IDO1) DMYGULD MT DTT DMYGULD MA Inhibitor DMYGULD RN S-benzylisothiourea derivatives as small-molecule inhibitors of indoleamine-2,3-dioxygenase. Bioorg Med Chem Lett. 2010 Sep 1;20(17):5126-9. DMYGULD RU https://pubmed.ncbi.nlm.nih.gov/20688518 DMNXDWV DI DMNXDWV DMNXDWV DN S-(4-Ethylbenzyl)isothiourea hydrochloride DMNXDWV MI TTZJYKH DMNXDWV MN Indoleamine 2,3-dioxygenase 1 (IDO1) DMNXDWV MT DTT DMNXDWV MA Inhibitor DMNXDWV RN S-benzylisothiourea derivatives as small-molecule inhibitors of indoleamine-2,3-dioxygenase. Bioorg Med Chem Lett. 2010 Sep 1;20(17):5126-9. DMNXDWV RU https://pubmed.ncbi.nlm.nih.gov/20688518 DM10MET DI DM10MET DM10MET DN S-(4-Fluorobenzyl)isothiourea hydrochloride DM10MET MI TTZJYKH DM10MET MN Indoleamine 2,3-dioxygenase 1 (IDO1) DM10MET MT DTT DM10MET MA Inhibitor DM10MET RN S-benzylisothiourea derivatives as small-molecule inhibitors of indoleamine-2,3-dioxygenase. Bioorg Med Chem Lett. 2010 Sep 1;20(17):5126-9. DM10MET RU https://pubmed.ncbi.nlm.nih.gov/20688518 DM4XWAU DI DM4XWAU DM4XWAU DN S-(4-Methoxybenzyl)isothiourea hydrochloride DM4XWAU MI TTZJYKH DM4XWAU MN Indoleamine 2,3-dioxygenase 1 (IDO1) DM4XWAU MT DTT DM4XWAU MA Inhibitor DM4XWAU RN S-benzylisothiourea derivatives as small-molecule inhibitors of indoleamine-2,3-dioxygenase. Bioorg Med Chem Lett. 2010 Sep 1;20(17):5126-9. DM4XWAU RU https://pubmed.ncbi.nlm.nih.gov/20688518 DMAGLI8 DI DMAGLI8 DMAGLI8 DN S-(4-Methylbenzyl)isothiourea hydrochloride DMAGLI8 MI TTZJYKH DMAGLI8 MN Indoleamine 2,3-dioxygenase 1 (IDO1) DMAGLI8 MT DTT DMAGLI8 MA Inhibitor DMAGLI8 RN S-benzylisothiourea derivatives as small-molecule inhibitors of indoleamine-2,3-dioxygenase. Bioorg Med Chem Lett. 2010 Sep 1;20(17):5126-9. DMAGLI8 RU https://pubmed.ncbi.nlm.nih.gov/20688518 DMYRBO0 DI DMYRBO0 DMYRBO0 DN S-(4-Nitrobenzyl)isothiourea hydrochloride DMYRBO0 MI TTZJYKH DMYRBO0 MN Indoleamine 2,3-dioxygenase 1 (IDO1) DMYRBO0 MT DTT DMYRBO0 MA Inhibitor DMYRBO0 RN S-benzylisothiourea derivatives as small-molecule inhibitors of indoleamine-2,3-dioxygenase. Bioorg Med Chem Lett. 2010 Sep 1;20(17):5126-9. DMYRBO0 RU https://pubmed.ncbi.nlm.nih.gov/20688518 DMSCHL0 DI DMSCHL0 DMSCHL0 DN S-(Dimethylarsenic)Cysteine DMSCHL0 MI TT5DOVB DMSCHL0 MN Cytomegalovirus Protease (CMV UL80) DMSCHL0 MT DTT DMSCHL0 MA Inhibitor DMSCHL0 RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMSCHL0 RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMSCHL0 DI DMSCHL0 DMSCHL0 DN S-(Dimethylarsenic)Cysteine DMSCHL0 MI TTCM4B3 DMSCHL0 MN Nitric-oxide synthase endothelial (NOS3) DMSCHL0 MT DTT DMSCHL0 MA Inhibitor DMSCHL0 RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMSCHL0 RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMSCHL0 DI DMSCHL0 DMSCHL0 DN S-(Dimethylarsenic)Cysteine DMSCHL0 MI TTY7ZHS DMSCHL0 MN Toll-like receptor 2 (TLR2) DMSCHL0 MT DTT DMSCHL0 MA Inhibitor DMSCHL0 RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMSCHL0 RU https://pubmed.ncbi.nlm.nih.gov/17139284 DM3FXPV DI DM3FXPV DM3FXPV DN S-(N-4bromophenyl-N-hydroxycarbamoyl)glutathione DM3FXPV MI TTV9A7R DM3FXPV MN Lactoylglutathione lyase (GLO1) DM3FXPV MT DTT DM3FXPV MA Inhibitor DM3FXPV RN Role of hydrophobic interactions in binding S-(N-aryl/alkyl-N-hydroxycarbamoyl)glutathiones to the active site of the antitumor target enzyme glyoxalase I. J Med Chem. 2000 Oct 19;43(21):3981-6. DM3FXPV RU https://pubmed.ncbi.nlm.nih.gov/11052803 DMPURE8 DI DMPURE8 DMPURE8 DN S-(N-4chlorophenyl-N-hydroxycarbamoyl)glutathione DMPURE8 MI TTV9A7R DMPURE8 MN Lactoylglutathione lyase (GLO1) DMPURE8 MT DTT DMPURE8 MA Inhibitor DMPURE8 RN Role of hydrophobic interactions in binding S-(N-aryl/alkyl-N-hydroxycarbamoyl)glutathiones to the active site of the antitumor target enzyme glyoxalase I. J Med Chem. 2000 Oct 19;43(21):3981-6. DMPURE8 RU https://pubmed.ncbi.nlm.nih.gov/11052803 DMU7EQV DI DMU7EQV DMU7EQV DN S-(N-butyl-N-hydroxycarbamoyl)glutathione DMU7EQV MI TTV9A7R DMU7EQV MN Lactoylglutathione lyase (GLO1) DMU7EQV MT DTT DMU7EQV MA Inhibitor DMU7EQV RN Role of hydrophobic interactions in binding S-(N-aryl/alkyl-N-hydroxycarbamoyl)glutathiones to the active site of the antitumor target enzyme glyoxalase I. J Med Chem. 2000 Oct 19;43(21):3981-6. DMU7EQV RU https://pubmed.ncbi.nlm.nih.gov/11052803 DMMETC2 DI DMMETC2 DMMETC2 DN S-(N-ethyl-N-hydroxycarbamoyl)glutathione DMMETC2 MI TTV9A7R DMMETC2 MN Lactoylglutathione lyase (GLO1) DMMETC2 MT DTT DMMETC2 MA Inhibitor DMMETC2 RN Role of hydrophobic interactions in binding S-(N-aryl/alkyl-N-hydroxycarbamoyl)glutathiones to the active site of the antitumor target enzyme glyoxalase I. J Med Chem. 2000 Oct 19;43(21):3981-6. DMMETC2 RU https://pubmed.ncbi.nlm.nih.gov/11052803 DMV6T1Q DI DMV6T1Q DMV6T1Q DN S-(N-heptyl-N-hydroxycarbamoyl)glutathione DMV6T1Q MI TTV9A7R DMV6T1Q MN Lactoylglutathione lyase (GLO1) DMV6T1Q MT DTT DMV6T1Q MA Inhibitor DMV6T1Q RN Role of hydrophobic interactions in binding S-(N-aryl/alkyl-N-hydroxycarbamoyl)glutathiones to the active site of the antitumor target enzyme glyoxalase I. J Med Chem. 2000 Oct 19;43(21):3981-6. DMV6T1Q RU https://pubmed.ncbi.nlm.nih.gov/11052803 DMSWHMI DI DMSWHMI DMSWHMI DN S-(N-hexyl-N-hydroxycarbamoyl)glutathione DMSWHMI MI TTV9A7R DMSWHMI MN Lactoylglutathione lyase (GLO1) DMSWHMI MT DTT DMSWHMI MA Inhibitor DMSWHMI RN Role of hydrophobic interactions in binding S-(N-aryl/alkyl-N-hydroxycarbamoyl)glutathiones to the active site of the antitumor target enzyme glyoxalase I. J Med Chem. 2000 Oct 19;43(21):3981-6. DMSWHMI RU https://pubmed.ncbi.nlm.nih.gov/11052803 DM1AHIW DI DM1AHIW DM1AHIW DN S-(N-Hydroxy-N-Iodophenylcarbamoyl)Glutathione DM1AHIW MI TTV9A7R DM1AHIW MN Lactoylglutathione lyase (GLO1) DM1AHIW MT DTT DM1AHIW MA Inhibitor DM1AHIW RN DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Nucleic Acids Res. 2011 Jan;39(Database issue):D1035-41. DM1AHIW RU https://pubmed.ncbi.nlm.nih.gov/21059682 DM1C9W3 DI DM1C9W3 DM1C9W3 DN S-(N-methyl-N-hydroxycarbamoyl)glutathione DM1C9W3 MI TTV9A7R DM1C9W3 MN Lactoylglutathione lyase (GLO1) DM1C9W3 MT DTT DM1C9W3 MA Inhibitor DM1C9W3 RN Role of hydrophobic interactions in binding S-(N-aryl/alkyl-N-hydroxycarbamoyl)glutathiones to the active site of the antitumor target enzyme glyoxalase I. J Med Chem. 2000 Oct 19;43(21):3981-6. DM1C9W3 RU https://pubmed.ncbi.nlm.nih.gov/11052803 DM4E9J2 DI DM4E9J2 DM4E9J2 DN S-(N-pentyl-N-hydroxycarbamoyl)glutathione DM4E9J2 MI TTV9A7R DM4E9J2 MN Lactoylglutathione lyase (GLO1) DM4E9J2 MT DTT DM4E9J2 MA Inhibitor DM4E9J2 RN Role of hydrophobic interactions in binding S-(N-aryl/alkyl-N-hydroxycarbamoyl)glutathiones to the active site of the antitumor target enzyme glyoxalase I. J Med Chem. 2000 Oct 19;43(21):3981-6. DM4E9J2 RU https://pubmed.ncbi.nlm.nih.gov/11052803 DMECAS0 DI DMECAS0 DMECAS0 DN S-(N-phenyl-N-hydroxycarbamoyl)glutathione DMECAS0 MI TTV9A7R DMECAS0 MN Lactoylglutathione lyase (GLO1) DMECAS0 MT DTT DMECAS0 MA Inhibitor DMECAS0 RN Role of hydrophobic interactions in binding S-(N-aryl/alkyl-N-hydroxycarbamoyl)glutathiones to the active site of the antitumor target enzyme glyoxalase I. J Med Chem. 2000 Oct 19;43(21):3981-6. DMECAS0 RU https://pubmed.ncbi.nlm.nih.gov/11052803 DMRFKZ6 DI DMRFKZ6 DMRFKZ6 DN S-(N-propyl-N-hydroxycarbamoyl)glutathione DMRFKZ6 MI TTV9A7R DMRFKZ6 MN Lactoylglutathione lyase (GLO1) DMRFKZ6 MT DTT DMRFKZ6 MA Inhibitor DMRFKZ6 RN Role of hydrophobic interactions in binding S-(N-aryl/alkyl-N-hydroxycarbamoyl)glutathiones to the active site of the antitumor target enzyme glyoxalase I. J Med Chem. 2000 Oct 19;43(21):3981-6. DMRFKZ6 RU https://pubmed.ncbi.nlm.nih.gov/11052803 DMLPAD8 DI DMLPAD8 DMLPAD8 DN S,S-(2-Hydroxyethyl)Thiocysteine DMLPAD8 MI TTU6BFZ DMLPAD8 MN Candida Thymidylate synthase (Candi TMP1) DMLPAD8 MT DTT DMLPAD8 MA Inhibitor DMLPAD8 RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMLPAD8 RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMLPAD8 DI DMLPAD8 DMLPAD8 DN S,S-(2-Hydroxyethyl)Thiocysteine DMLPAD8 MI TTJHKYD DMLPAD8 MN Delta-aminolevulinic acid dehydratase (ALAD) DMLPAD8 MT DTT DMLPAD8 MA Inhibitor DMLPAD8 RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMLPAD8 RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMLPAD8 DI DMLPAD8 DMLPAD8 DN S,S-(2-Hydroxyethyl)Thiocysteine DMLPAD8 MI TT1KW50 DMLPAD8 MN Maspin (SERPINB5) DMLPAD8 MT DTT DMLPAD8 MA Inhibitor DMLPAD8 RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMLPAD8 RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMLPAD8 DI DMLPAD8 DMLPAD8 DN S,S-(2-Hydroxyethyl)Thiocysteine DMLPAD8 MI TTKGY3F DMLPAD8 MN Mycobacterium DTDP-dehydrorhamnose epimerase rmlC (MycB rmlC) DMLPAD8 MT DTT DMLPAD8 MA Inhibitor DMLPAD8 RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMLPAD8 RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMLPAD8 DI DMLPAD8 DMLPAD8 DN S,S-(2-Hydroxyethyl)Thiocysteine DMLPAD8 MI TTHQENC DMLPAD8 MN Phosphodiesterase 1 (PDE1) DMLPAD8 MT DTT DMLPAD8 MA Inhibitor DMLPAD8 RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMLPAD8 RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMLPAD8 DI DMLPAD8 DMLPAD8 DN S,S-(2-Hydroxyethyl)Thiocysteine DMLPAD8 MI TTVIAT9 DMLPAD8 MN Phosphodiesterase 4B (PDE4B) DMLPAD8 MT DTT DMLPAD8 MA Inhibitor DMLPAD8 RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMLPAD8 RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMT36AB DI DMT36AB DMT36AB DN S-024 DMT36AB MI TTTU902 DMT36AB MN Checkpoint kinase-1 (CHK1) DMT36AB MT DTT DMT36AB MA Inhibitor DMT36AB RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1987). DMT36AB RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1987 DMANSCK DI DMANSCK DMANSCK DN S-070 DMANSCK MI TTTU902 DMANSCK MN Checkpoint kinase-1 (CHK1) DMANSCK MT DTT DMANSCK MA Inhibitor DMANSCK RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1987). DMANSCK RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1987 DMANSCK DI DMANSCK DMANSCK DN S-070 DMANSCK MI TTVDSZ0 DMANSCK MN Poly [ADP-ribose] polymerase 1 (PARP1) DMANSCK MT DTT DMANSCK MA Inhibitor DMANSCK RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2771). DMANSCK RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2771 DMIBEY6 DI DMIBEY6 DMIBEY6 DN S-1,2-propanediol DMIBEY6 MI DE9TLVP DMIBEY6 MN Diol dehydratase (pddA) DMIBEY6 MT DME DMIBEY6 MA Metabolism DMIBEY6 RN 1,2-Propanediol dehydration in Roseburia inulinivorans: structural basis for substrates and enantiomers selectivity. J Biol Chem. 2016 Jul 22;291(30):15515-26. DMIBEY6 RU https://pubmed.ncbi.nlm.nih.gov/27252380 DM2JYQA DI DM2JYQA DM2JYQA DN S109 DM2JYQA MI TTCJUR4 DM2JYQA MN Exportin-1 (XPO1) DM2JYQA MT DTT DM2JYQA MA Inhibitor DM2JYQA RN Reversible inhibitor of CRM1 sensitizes glioblastoma cells to radiation by blocking the NF-B signaling pathway. Cancer Cell Int. 2020 Mar 30;20:97. DM2JYQA RU https://pubmed.ncbi.nlm.nih.gov/32256206 DMRVUCY DI DMRVUCY DMRVUCY DN S-111 DMRVUCY MI TTVDSZ0 DMRVUCY MN Poly [ADP-ribose] polymerase 1 (PARP1) DMRVUCY MT DTT DMRVUCY MA Inhibitor DMRVUCY RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2771). DMRVUCY RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2771 DMN6HE3 DI DMN6HE3 DMN6HE3 DN S136492 DMN6HE3 MI TT5U914 DMN6HE3 MN Endothelin-converting enzyme 2 (ECE2) DMN6HE3 MT DTT DMN6HE3 MA Inhibitor DMN6HE3 RN Homology modeling and site-directed mutagenesis to identify selective inhibitors of endothelin-converting enzyme-2. J Med Chem. 2008 Jun 26;51(12):3378-87. DMN6HE3 RU https://pubmed.ncbi.nlm.nih.gov/18507370 DMHVEJF DI DMHVEJF DMHVEJF DN S-14671 DMHVEJF MI TTSQIFT DMHVEJF MN 5-HT 1A receptor (HTR1A) DMHVEJF MT DTT DMHVEJF MA Agonist DMHVEJF RN Labelling of recombinant human and native rat serotonin 5-HT1A receptors by a novel, selective radioligand, [3H]-S 15535: definition of its binding profile using agonists, antagonists and inverse agonists. Naunyn Schmiedebergs Arch Pharmacol. 1998 Mar;357(3):205-17. DMHVEJF RU https://pubmed.ncbi.nlm.nih.gov/9550290 DMD4KLQ DI DMD4KLQ DMD4KLQ DN S1627 DMD4KLQ MI TTRPDBG DMD4KLQ MN Inhibitor of nuclear factor kappa-B kinase (IKK) DMD4KLQ MT DTT DMD4KLQ MA Inhibitor DMD4KLQ RN Specific Inhibition of IkappaB kinase reduces hyperalgesia in inflammatory and neuropathic pain models in rats. J Neurosci. 2004 Feb 18;24(7):1637-45. DMD4KLQ RU https://pubmed.ncbi.nlm.nih.gov/14973242 DM589XM DI DM589XM DM589XM DN S-19528 DM589XM MI TTRK9JT DM589XM MN Neuropeptide Y receptor type 1 (NPY1R) DM589XM MT DTT DM589XM MA Antagonist DM589XM RN Emerging drugs for eating disorder treatment. Expert Opin Emerg Drugs. 2006 May;11(2):315-36. DM589XM RU https://pubmed.ncbi.nlm.nih.gov/16634704 DM589XM DI DM589XM DM589XM DN S-19528 DM589XM MI TTY6EWA DM589XM MN Neuropeptide Y receptor type 5 (NPY5R) DM589XM MT DTT DM589XM MA Antagonist DM589XM RN Emerging drugs for eating disorder treatment. Expert Opin Emerg Drugs. 2006 May;11(2):315-36. DM589XM RU https://pubmed.ncbi.nlm.nih.gov/16634704 DMU9F7K DI DMU9F7K DMU9F7K DN S-2-(o-toluidino)-2-oxoethyl carbamothioate DMU9F7K MI TTULVH8 DMU9F7K MN Tyrosinase (TYR) DMU9F7K MT DTT DMU9F7K MA Inhibitor DMU9F7K RN Discovery of small-molecule inhibitors of tyrosinase. Bioorg Med Chem Lett. 2007 Dec 15;17(24):6871-5. DMU9F7K RU https://pubmed.ncbi.nlm.nih.gov/17964155 DMTH15E DI DMTH15E DMTH15E DN S-2,9-dioxo-9-(phenylamino)nonyl ethanethioate DMTH15E MI TTT6LFV DMTH15E MN Histone deacetylase 8 (HDAC8) DMTH15E MT DTT DMTH15E MA Inhibitor DMTH15E RN Histone deacetylase inhibitors: from bench to clinic. J Med Chem. 2008 Mar 27;51(6):1505-29. DMTH15E RU https://pubmed.ncbi.nlm.nih.gov/18247554 DMOJ9N6 DI DMOJ9N6 DMOJ9N6 DN S-21007 DMOJ9N6 MI TTNXLKE DMOJ9N6 MN 5-HT 3 receptor (5HT3R) DMOJ9N6 MT DTT DMOJ9N6 MA Modulator DMOJ9N6 RN Effects of S-21007, a potent 5-HT3 partial agonist, in mouse anxiety. Zhongguo Yao Li Xue Bao. 1999 Sep;20(9):805-12. DMOJ9N6 RU https://www.ncbi.nlm.nih.gov/pubmed/11245088 DM4S5TQ DI DM4S5TQ DM4S5TQ DN S22153 DM4S5TQ MI TT0WAIE DM4S5TQ MN Melatonin receptor type 1A (MTNR1A) DM4S5TQ MT DTT DM4S5TQ MA Antagonist DM4S5TQ RN New selective ligands of human cloned melatonin MT1 and MT2 receptors. Naunyn Schmiedebergs Arch Pharmacol. 2003 Jun;367(6):553-61. DM4S5TQ RU https://pubmed.ncbi.nlm.nih.gov/12764576 DM3GS2X DI DM3GS2X DM3GS2X DN S-2238 DM3GS2X MI TT6L509 DM3GS2X MN Coagulation factor IIa (F2) DM3GS2X MT DTT DM3GS2X MA Inhibitor DM3GS2X RN Screening for selective thrombin inhibitors in mushrooms. Blood Coagul Fibrinolysis. 2001 Mar;12(2):123-8. DM3GS2X RU https://pubmed.ncbi.nlm.nih.gov/11302474 DM9RU46 DI DM9RU46 DM9RU46 DN S24014 DM9RU46 MI TT0WAIE DM9RU46 MN Melatonin receptor type 1A (MTNR1A) DM9RU46 MT DTT DM9RU46 MA Agonist DM9RU46 RN New selective ligands of human cloned melatonin MT1 and MT2 receptors. Naunyn Schmiedebergs Arch Pharmacol. 2003 Jun;367(6):553-61. DM9RU46 RU https://pubmed.ncbi.nlm.nih.gov/12764576 DM1HAD0 DI DM1HAD0 DM1HAD0 DN S24773 DM1HAD0 MI TT0WAIE DM1HAD0 MN Melatonin receptor type 1A (MTNR1A) DM1HAD0 MT DTT DM1HAD0 MA Agonist DM1HAD0 RN New selective ligands of human cloned melatonin MT1 and MT2 receptors. Naunyn Schmiedebergs Arch Pharmacol. 2003 Jun;367(6):553-61. DM1HAD0 RU https://pubmed.ncbi.nlm.nih.gov/12764576 DMBUD1M DI DMBUD1M DMBUD1M DN S-25585 DMBUD1M MI TTRK9JT DMBUD1M MN Neuropeptide Y receptor type 1 (NPY1R) DMBUD1M MT DTT DMBUD1M MA Antagonist DMBUD1M RN Emerging drugs for eating disorder treatment. Expert Opin Emerg Drugs. 2006 May;11(2):315-36. DMBUD1M RU https://pubmed.ncbi.nlm.nih.gov/16634704 DMBUD1M DI DMBUD1M DMBUD1M DN S-25585 DMBUD1M MI TTY6EWA DMBUD1M MN Neuropeptide Y receptor type 5 (NPY5R) DMBUD1M MT DTT DMBUD1M MA Antagonist DMBUD1M RN Emerging drugs for eating disorder treatment. Expert Opin Emerg Drugs. 2006 May;11(2):315-36. DMBUD1M RU https://pubmed.ncbi.nlm.nih.gov/16634704 DMCJ86U DI DMCJ86U DMCJ86U DN S26131 DMCJ86U MI TT0WAIE DMCJ86U MN Melatonin receptor type 1A (MTNR1A) DMCJ86U MT DTT DMCJ86U MA Antagonist DMCJ86U RN New selective ligands of human cloned melatonin MT1 and MT2 receptors. Naunyn Schmiedebergs Arch Pharmacol. 2003 Jun;367(6):553-61. DMCJ86U RU https://pubmed.ncbi.nlm.nih.gov/12764576 DMLJITC DI DMLJITC DMLJITC DN S26284 DMLJITC MI TT0WAIE DMLJITC MN Melatonin receptor type 1A (MTNR1A) DMLJITC MT DTT DMLJITC MA Agonist DMLJITC RN New selective ligands of human cloned melatonin MT1 and MT2 receptors. Naunyn Schmiedebergs Arch Pharmacol. 2003 Jun;367(6):553-61. DMLJITC RU https://pubmed.ncbi.nlm.nih.gov/12764576 DM3Z6TI DI DM3Z6TI DM3Z6TI DN S33005 DM3Z6TI MI TTAWNKZ DM3Z6TI MN Norepinephrine transporter (NET) DM3Z6TI MT DTT DM3Z6TI MA Inhibitor DM3Z6TI RN Serotonin reuptake inhibitors: the corner stone in treatment of depression for half a century--a medicinal chemistry survey. Curr Top Med Chem. 2006;6(17):1801-23. DM3Z6TI RU https://pubmed.ncbi.nlm.nih.gov/17017959 DM3Z6TI DI DM3Z6TI DM3Z6TI DN S33005 DM3Z6TI MI TT3ROYC DM3Z6TI MN Serotonin transporter (SERT) DM3Z6TI MT DTT DM3Z6TI MA Inhibitor DM3Z6TI RN Serotonin reuptake inhibitors: the corner stone in treatment of depression for half a century--a medicinal chemistry survey. Curr Top Med Chem. 2006;6(17):1801-23. DM3Z6TI RU https://pubmed.ncbi.nlm.nih.gov/17017959 DMZLQ5W DI DMZLQ5W DMZLQ5W DN S-34324 DMZLQ5W MI TTWG9A4 DMZLQ5W MN Adrenergic receptor alpha-2A (ADRA2A) DMZLQ5W MT DTT DMZLQ5W MA Inhibitor DMZLQ5W RN Discovery of a new series of centrally active tricyclic isoxazoles combining serotonin (5-HT) reuptake inhibition with alpha2-adrenoceptor blocking... J Med Chem. 2005 Mar 24;48(6):2054-71. DMZLQ5W RU https://pubmed.ncbi.nlm.nih.gov/15771448 DMZLQ5W DI DMZLQ5W DMZLQ5W DN S-34324 DMZLQ5W MI TTWM4TY DMZLQ5W MN Adrenergic receptor alpha-2B (ADRA2B) DMZLQ5W MT DTT DMZLQ5W MA Inhibitor DMZLQ5W RN Discovery of a new series of centrally active tricyclic isoxazoles combining serotonin (5-HT) reuptake inhibition with alpha2-adrenoceptor blocking... J Med Chem. 2005 Mar 24;48(6):2054-71. DMZLQ5W RU https://pubmed.ncbi.nlm.nih.gov/15771448 DMZLQ5W DI DMZLQ5W DMZLQ5W DN S-34324 DMZLQ5W MI TT2NUT5 DMZLQ5W MN Adrenergic receptor alpha-2C (ADRA2C) DMZLQ5W MT DTT DMZLQ5W MA Inhibitor DMZLQ5W RN Discovery of a new series of centrally active tricyclic isoxazoles combining serotonin (5-HT) reuptake inhibition with alpha2-adrenoceptor blocking... J Med Chem. 2005 Mar 24;48(6):2054-71. DMZLQ5W RU https://pubmed.ncbi.nlm.nih.gov/15771448 DMZLQ5W DI DMZLQ5W DMZLQ5W DN S-34324 DMZLQ5W MI TTAWNKZ DMZLQ5W MN Norepinephrine transporter (NET) DMZLQ5W MT DTT DMZLQ5W MA Inhibitor DMZLQ5W RN Discovery of a new series of centrally active tricyclic isoxazoles combining serotonin (5-HT) reuptake inhibition with alpha2-adrenoceptor blocking... J Med Chem. 2005 Mar 24;48(6):2054-71. DMZLQ5W RU https://pubmed.ncbi.nlm.nih.gov/15771448 DMZLQ5W DI DMZLQ5W DMZLQ5W DN S-34324 DMZLQ5W MI TT3ROYC DMZLQ5W MN Serotonin transporter (SERT) DMZLQ5W MT DTT DMZLQ5W MA Inhibitor DMZLQ5W RN Discovery of a new series of centrally active tricyclic isoxazoles combining serotonin (5-HT) reuptake inhibition with alpha2-adrenoceptor blocking... J Med Chem. 2005 Mar 24;48(6):2054-71. DMZLQ5W RU https://pubmed.ncbi.nlm.nih.gov/15771448 DM84DMW DI DM84DMW DM84DMW DN S3969 DM84DMW MI TTQM7TE DM84DMW MN Amiloride-sensitive sodium channel (ENaC) DM84DMW MT DTT DM84DMW MA Activator DM84DMW RN Small molecule activator of the human epithelial sodium channel. J Biol Chem. 2008 May 2;283(18):11981-94. DM84DMW RU https://pubmed.ncbi.nlm.nih.gov/18326490 DME5HIR DI DME5HIR DME5HIR DN S-4048 DME5HIR MI TT1KPBZ DME5HIR MN Glucose-6-phosphate translocase (SLC37A4) DME5HIR MT DTT DME5HIR MA Inhibitor DME5HIR RN Glucose release from GLUT2-null hepatocytes: characterization of a major and a minor pathway. Am J Physiol Endocrinol Metab. 2002 Apr;282(4):E794-801. DME5HIR RU https://pubmed.ncbi.nlm.nih.gov/11882499 DMFC430 DI DMFC430 DMFC430 DN S-41744 DMFC430 MI TTZPO1L DMFC430 MN Substance-P receptor (TACR1) DMFC430 MT DTT DMFC430 MA Antagonist DMFC430 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 360). DMFC430 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=360 DMML1HC DI DMML1HC DMML1HC DN S6716 DMML1HC MI TTW5UDX DMML1HC MN Urotensin II receptor (UTS2R) DMML1HC MT DTT DMML1HC MA Antagonist DMML1HC RN Identification of nonpeptidic urotensin II receptor antagonists by virtual screening based on a pharmacophore model derived from structure-activity relationships and nuclear magnetic resonance studies on urotensin II. J Med Chem. 2002 Apr 25;45(9):1799-805. DMML1HC RU https://pubmed.ncbi.nlm.nih.gov/11960491 DMIKJNL DI DMIKJNL DMIKJNL DN S6-nitrobenzyl mercaptopurine riboside DMIKJNL MI TTLXAKE DMIKJNL MN Solute carrier family 29 member 1 (SLC29A1) DMIKJNL MT DTT DMIKJNL MA Inhibitor DMIKJNL RN Synthesis and biological evaluation of phloridzin analogs as human concentrative nucleoside transporter 3 (hCNT3) inhibitors. Bioorg Med Chem Lett. 2009 Feb 1;19(3):917-21. DMIKJNL RU https://pubmed.ncbi.nlm.nih.gov/19097778 DMHB6UY DI DMHB6UY DMHB6UY DN S-9947 DMHB6UY MI TTW0CMT DMHB6UY MN Voltage-gated potassium channel Kv1.5 (KCNA5) DMHB6UY MT DTT DMHB6UY MA Blocker DMHB6UY RN New antiarrhythmic agents for atrial fibrillation and atrial flutter. Expert Opin Emerg Drugs. 2005 May;10(2):311-22. DMHB6UY RU https://pubmed.ncbi.nlm.nih.gov/15934869 DMVA5FE DI DMVA5FE DMVA5FE DN SA-6541 DMVA5FE MI TTXZEAJ DMVA5FE MN Leukotriene A-4 hydrolase (LTA4H) DMVA5FE MT DTT DMVA5FE MA Inhibitor DMVA5FE RN Synthesis and biological evaluation of N-mercaptoacylcysteine derivatives as leukotriene A4 hydrolase inhibitors. Bioorg Med Chem Lett. 2009 Jan 15;19(2):442-6. DMVA5FE RU https://pubmed.ncbi.nlm.nih.gov/19042128 DM5MBX7 DI DM5MBX7 DM5MBX7 DN Sabadinine DM5MBX7 MI TTJLVBO DM5MBX7 MN Coronavirus Main proteinase (CoV 1a) DM5MBX7 MT DTT DM5MBX7 MA Inhibitor DM5MBX7 RN Sabadinine: a potential non-peptide anti-severe acute-respiratory-syndrome agent identified using structure-aided design. J Med Chem. 2004 Feb 26;47(5):1079-80. DM5MBX7 RU https://pubmed.ncbi.nlm.nih.gov/14971887 DMRA736 DI DMRA736 DMRA736 DN Saccharin DMRA736 MI TTUNARX DMRA736 MN Carbonic anhydrase (CA) DMRA736 MT DTT DMRA736 MA Inhibitor DMRA736 RN Carbonic anhydrase inhibitors. Characterization and inhibition studies of the most active beta-carbonic anhydrase from Mycobacterium tuberculosis, ... Bioorg Med Chem Lett. 2009 Dec 1;19(23):6649-54. DMRA736 RU https://pubmed.ncbi.nlm.nih.gov/19846301 DMRA736 DI DMRA736 DMRA736 DN Saccharin DMRA736 MI TTHQPL7 DMRA736 MN Carbonic anhydrase I (CA-I) DMRA736 MT DTT DMRA736 MA Inhibitor DMRA736 RN Mutation of Phe91 to Asn in human carbonic anhydrase I unexpectedly enhanced both catalytic activity and affinity for sulfonamide inhibitors. Bioorg Med Chem. 2010 Aug 1;18(15):5498-503. DMRA736 RU https://pubmed.ncbi.nlm.nih.gov/20624682 DMRA736 DI DMRA736 DMRA736 DN Saccharin DMRA736 MI TTANPDJ DMRA736 MN Carbonic anhydrase II (CA-II) DMRA736 MT DTT DMRA736 MA Inhibitor DMRA736 RN Mutation of Phe91 to Asn in human carbonic anhydrase I unexpectedly enhanced both catalytic activity and affinity for sulfonamide inhibitors. Bioorg Med Chem. 2010 Aug 1;18(15):5498-503. DMRA736 RU https://pubmed.ncbi.nlm.nih.gov/20624682 DMRA736 DI DMRA736 DMRA736 DN Saccharin DMRA736 MI TT2LVK8 DMRA736 MN Carbonic anhydrase IX (CA-IX) DMRA736 MT DTT DMRA736 MA Inhibitor DMRA736 RN Carbonic anhydrase inhibitors: copper(II) complexes of polyamino-polycarboxylamido aromatic/heterocyclic sulfonamides are very potent inhibitors of... Bioorg Med Chem Lett. 2008 Jan 15;18(2):836-41. DMRA736 RU https://pubmed.ncbi.nlm.nih.gov/18042384 DMRA736 DI DMRA736 DMRA736 DN Saccharin DMRA736 MI TTSYM0R DMRA736 MN Carbonic anhydrase XII (CA-XII) DMRA736 MT DTT DMRA736 MA Inhibitor DMRA736 RN Carbonic anhydrase inhibitors: copper(II) complexes of polyamino-polycarboxylamido aromatic/heterocyclic sulfonamides are very potent inhibitors of... Bioorg Med Chem Lett. 2008 Jan 15;18(2):836-41. DMRA736 RU https://pubmed.ncbi.nlm.nih.gov/18042384 DM3TO27 DI DM3TO27 DM3TO27 DN saclofen DM3TO27 MI TTDCVZW DM3TO27 MN Gamma-aminobutyric acid B receptor (GABBR) DM3TO27 MT DTT DM3TO27 MA Antagonist DM3TO27 RN Expression cloning of GABA(B) receptors uncovers similarity to metabotropic glutamate receptors. Nature. 1997 Mar 20;386(6622):239-46. DM3TO27 RU https://pubmed.ncbi.nlm.nih.gov/9069281 DMZWGVP DI DMZWGVP DMZWGVP DN Saframycin A DMZWGVP MI TTUGSWA DMZWGVP MN Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) DMZWGVP MT DTT DMZWGVP MA Binder DMZWGVP RN Identification of GAPDH as a protein target of the saframycin antiproliferative agents. Proc Natl Acad Sci U S A. 2004 Apr 20;101(16):5862-6. DMZWGVP RU https://pubmed.ncbi.nlm.nih.gov/15079082 DMHOG7W DI DMHOG7W DMHOG7W DN SAG DMHOG7W MI TTSJ9E7 DMHOG7W MN Short transient receptor potential channel 2 (TRPC2) DMHOG7W MT DTT DMHOG7W MA Activator DMHOG7W RN A diacylglycerol-gated cation channel in vomeronasal neuron dendrites is impaired in TRPC2 mutant mice: mechanism of pheromone transduction. Neuron. 2003 Oct 30;40(3):551-61. DMHOG7W RU https://pubmed.ncbi.nlm.nih.gov/14642279 DMHOG7W DI DMHOG7W DMHOG7W DN SAG DMHOG7W MI TTRBT3W DMHOG7W MN Short transient receptor potential channel 6 (TRPC6) DMHOG7W MT DTT DMHOG7W MA Activator DMHOG7W RN Direct activation of human TRPC6 and TRPC3 channels by diacylglycerol. Nature. 1999 Jan 21;397(6716):259-63. DMHOG7W RU https://pubmed.ncbi.nlm.nih.gov/9930701 DMLU6J0 DI DMLU6J0 DMLU6J0 DN SAIT301 DMLU6J0 MI TTKA5LP DMLU6J0 MN HGF/Met signaling pathway (HGF/Met pathway) DMLU6J0 MT DTT DMLU6J0 RN Nasopharyngeal carcinoma: Current treatment options and future directions. J Nasopharyng Carcinoma, 2014, 1(16): e16. DMLU6J0 RU http://journalofnasopharyngealcarcinoma.org/JNPC/article/view/30/227 DMUAQYZ DI DMUAQYZ DMUAQYZ DN sakuranetin DMUAQYZ MI TTK25J1 DMUAQYZ MN Adenosine A1 receptor (ADORA1) DMUAQYZ MT DTT DMUAQYZ MA Antagonist DMUAQYZ RN Synthesis and biological activities of flavonoid derivatives as A3 adenosine receptor antagonists. J Med Chem. 1996 Jun 7;39(12):2293-301. DMUAQYZ RU https://pubmed.ncbi.nlm.nih.gov/8691424 DMUAQYZ DI DMUAQYZ DMUAQYZ DN sakuranetin DMUAQYZ MI TTNE7KG DMUAQYZ MN Adenosine A2b receptor (ADORA2B) DMUAQYZ MT DTT DMUAQYZ MA Antagonist DMUAQYZ RN Synthesis and biological activities of flavonoid derivatives as A3 adenosine receptor antagonists. J Med Chem. 1996 Jun 7;39(12):2293-301. DMUAQYZ RU https://pubmed.ncbi.nlm.nih.gov/8691424 DMUAQYZ DI DMUAQYZ DMUAQYZ DN sakuranetin DMUAQYZ MI TTJFY5U DMUAQYZ MN Adenosine A3 receptor (ADORA3) DMUAQYZ MT DTT DMUAQYZ MA Antagonist DMUAQYZ RN Synthesis and biological activities of flavonoid derivatives as A3 adenosine receptor antagonists. J Med Chem. 1996 Jun 7;39(12):2293-301. DMUAQYZ RU https://pubmed.ncbi.nlm.nih.gov/8691424 DMGLSPC DI DMGLSPC DMGLSPC DN Salicylhydroxamic acid DMGLSPC MI TT3PQ2Y DMGLSPC MN Plasmodium Dihydroorotate dehydrogenase (Malaria DHOdehase) DMGLSPC MT DTT DMGLSPC MA Inhibitor DMGLSPC RN Effects of atovaquone and other inhibitors on Pneumocystis carinii dihydroorotate dehydrogenase. Antimicrob Agents Chemother. 1995 Feb;39(2):325-8. DMGLSPC RU https://pubmed.ncbi.nlm.nih.gov/7726490 DMUPCA6 DI DMUPCA6 DMUPCA6 DN s-allylglycine DMUPCA6 MI TT7UY6K DMUPCA6 MN Glutamate decarboxylase 2 (GAD2) DMUPCA6 MT DTT DMUPCA6 MA Inhibitor DMUPCA6 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1273). DMUPCA6 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1273 DMUPCA6 DI DMUPCA6 DMUPCA6 DN s-allylglycine DMUPCA6 MI TTKGEP3 DMUPCA6 MN Glutamic acid decarboxylase 1 (GAD1) DMUPCA6 MT DTT DMUPCA6 MA Inhibitor DMUPCA6 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1272). DMUPCA6 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1272 DM8T1Y4 DI DM8T1Y4 DM8T1Y4 DN Salvinicin A DM8T1Y4 MI TTQW87Y DM8T1Y4 MN Opioid receptor kappa (OPRK1) DM8T1Y4 MT DTT DM8T1Y4 MA Inhibitor DM8T1Y4 RN Synthetic studies of neoclerodane diterpenes from Salvia divinorum: preparation and opioid receptor activity of salvinicin analogues. J Med Chem. 2007 Jul 26;50(15):3596-603. DM8T1Y4 RU https://pubmed.ncbi.nlm.nih.gov/17580847 DMB70T3 DI DMB70T3 DMB70T3 DN SALVINICIN B DMB70T3 MI TTQW87Y DMB70T3 MN Opioid receptor kappa (OPRK1) DMB70T3 MT DTT DMB70T3 MA Inhibitor DMB70T3 RN Synthetic studies of neoclerodane diterpenes from Salvia divinorum: preparation and opioid receptor activity of salvinicin analogues. J Med Chem. 2007 Jul 26;50(15):3596-603. DMB70T3 RU https://pubmed.ncbi.nlm.nih.gov/17580847 DMYH9Q5 DI DMYH9Q5 DMYH9Q5 DN Salvinorin A (ester) DMYH9Q5 MI TTQW87Y DMYH9Q5 MN Opioid receptor kappa (OPRK1) DMYH9Q5 MT DTT DMYH9Q5 MA Inhibitor DMYH9Q5 RN Synthesis and in vitro evaluation of salvinorin A analogues: effect of configuration at C(2) and substitution at C(18). Bioorg Med Chem Lett. 2006 Sep 1;16(17):4679-85. DMYH9Q5 RU https://pubmed.ncbi.nlm.nih.gov/16777411 DMBR7O0 DI DMBR7O0 DMBR7O0 DN SALVINORIN B DMBR7O0 MI TTQW87Y DMBR7O0 MN Opioid receptor kappa (OPRK1) DMBR7O0 MT DTT DMBR7O0 MA Inhibitor DMBR7O0 RN Herkinorin analogues with differential beta-arrestin-2 interactions. J Med Chem. 2008 Apr 24;51(8):2421-31. DMBR7O0 RU https://pubmed.ncbi.nlm.nih.gov/18380425 DM5ZE7F DI DM5ZE7F DM5ZE7F DN Salvinorin B 1-ethoxyethyl ether DM5ZE7F MI TTQW87Y DM5ZE7F MN Opioid receptor kappa (OPRK1) DM5ZE7F MT DTT DM5ZE7F MA Inhibitor DM5ZE7F RN Standard protecting groups create potent and selective kappa opioids: salvinorin B alkoxymethyl ethers. Bioorg Med Chem. 2008 Feb 1;16(3):1279-86. DM5ZE7F RU https://pubmed.ncbi.nlm.nih.gov/17981041 DM1DE3F DI DM1DE3F DM1DE3F DN Salvinorin B 2,2,2-trifluoroethoxymethyl ether DM1DE3F MI TTQW87Y DM1DE3F MN Opioid receptor kappa (OPRK1) DM1DE3F MT DTT DM1DE3F MA Inhibitor DM1DE3F RN Standard protecting groups create potent and selective kappa opioids: salvinorin B alkoxymethyl ethers. Bioorg Med Chem. 2008 Feb 1;16(3):1279-86. DM1DE3F RU https://pubmed.ncbi.nlm.nih.gov/17981041 DMBAXDU DI DMBAXDU DMBAXDU DN Salvinorin B 2-fluoroethoxymethyl ether DMBAXDU MI TTQW87Y DMBAXDU MN Opioid receptor kappa (OPRK1) DMBAXDU MT DTT DMBAXDU MA Inhibitor DMBAXDU RN Standard protecting groups create potent and selective kappa opioids: salvinorin B alkoxymethyl ethers. Bioorg Med Chem. 2008 Feb 1;16(3):1279-86. DMBAXDU RU https://pubmed.ncbi.nlm.nih.gov/17981041 DMD9A08 DI DMD9A08 DMD9A08 DN Salvinorin B 2-methoxy-2-propyl ether DMD9A08 MI TTQW87Y DMD9A08 MN Opioid receptor kappa (OPRK1) DMD9A08 MT DTT DMD9A08 MA Inhibitor DMD9A08 RN Standard protecting groups create potent and selective kappa opioids: salvinorin B alkoxymethyl ethers. Bioorg Med Chem. 2008 Feb 1;16(3):1279-86. DMD9A08 RU https://pubmed.ncbi.nlm.nih.gov/17981041 DM8UATD DI DM8UATD DM8UATD DN Salvinorin B 2-methoxyethoxymethyl ether DM8UATD MI TTQW87Y DM8UATD MN Opioid receptor kappa (OPRK1) DM8UATD MT DTT DM8UATD MA Inhibitor DM8UATD RN Standard protecting groups create potent and selective kappa opioids: salvinorin B alkoxymethyl ethers. Bioorg Med Chem. 2008 Feb 1;16(3):1279-86. DM8UATD RU https://pubmed.ncbi.nlm.nih.gov/17981041 DMKXEQ6 DI DMKXEQ6 DMKXEQ6 DN Salvinorin B benzyloxymethyl ether DMKXEQ6 MI TTQW87Y DMKXEQ6 MN Opioid receptor kappa (OPRK1) DMKXEQ6 MT DTT DMKXEQ6 MA Inhibitor DMKXEQ6 RN Standard protecting groups create potent and selective kappa opioids: salvinorin B alkoxymethyl ethers. Bioorg Med Chem. 2008 Feb 1;16(3):1279-86. DMKXEQ6 RU https://pubmed.ncbi.nlm.nih.gov/17981041 DM7Q12B DI DM7Q12B DM7Q12B DN Salvinorin B butoxymethyl ether DM7Q12B MI TTQW87Y DM7Q12B MN Opioid receptor kappa (OPRK1) DM7Q12B MT DTT DM7Q12B MA Inhibitor DM7Q12B RN Standard protecting groups create potent and selective kappa opioids: salvinorin B alkoxymethyl ethers. Bioorg Med Chem. 2008 Feb 1;16(3):1279-86. DM7Q12B RU https://pubmed.ncbi.nlm.nih.gov/17981041 DMP5WNL DI DMP5WNL DMP5WNL DN Salvinorin B ethoxymethyl ether DMP5WNL MI TTQW87Y DMP5WNL MN Opioid receptor kappa (OPRK1) DMP5WNL MT DTT DMP5WNL MA Inhibitor DMP5WNL RN Standard protecting groups create potent and selective kappa opioids: salvinorin B alkoxymethyl ethers. Bioorg Med Chem. 2008 Feb 1;16(3):1279-86. DMP5WNL RU https://pubmed.ncbi.nlm.nih.gov/17981041 DM01WOF DI DM01WOF DM01WOF DN Salvinorin B fluoromethyl ether DM01WOF MI TTQW87Y DM01WOF MN Opioid receptor kappa (OPRK1) DM01WOF MT DTT DM01WOF MA Inhibitor DM01WOF RN Standard protecting groups create potent and selective kappa opioids: salvinorin B alkoxymethyl ethers. Bioorg Med Chem. 2008 Feb 1;16(3):1279-86. DM01WOF RU https://pubmed.ncbi.nlm.nih.gov/17981041 DMSFXA3 DI DMSFXA3 DMSFXA3 DN Salvinorin B isopropoxymethyl ether DMSFXA3 MI TTQW87Y DMSFXA3 MN Opioid receptor kappa (OPRK1) DMSFXA3 MT DTT DMSFXA3 MA Inhibitor DMSFXA3 RN Standard protecting groups create potent and selective kappa opioids: salvinorin B alkoxymethyl ethers. Bioorg Med Chem. 2008 Feb 1;16(3):1279-86. DMSFXA3 RU https://pubmed.ncbi.nlm.nih.gov/17981041 DMZ51IE DI DMZ51IE DMZ51IE DN Salvinorin B methoxymethyl ether DMZ51IE MI TTQW87Y DMZ51IE MN Opioid receptor kappa (OPRK1) DMZ51IE MT DTT DMZ51IE MA Inhibitor DMZ51IE RN Standard protecting groups create potent and selective kappa opioids: salvinorin B alkoxymethyl ethers. Bioorg Med Chem. 2008 Feb 1;16(3):1279-86. DMZ51IE RU https://pubmed.ncbi.nlm.nih.gov/17981041 DMKDMPL DI DMKDMPL DMKDMPL DN Salvinorin B methylthiomethyl ether DMKDMPL MI TTQW87Y DMKDMPL MN Opioid receptor kappa (OPRK1) DMKDMPL MT DTT DMKDMPL MA Inhibitor DMKDMPL RN Standard protecting groups create potent and selective kappa opioids: salvinorin B alkoxymethyl ethers. Bioorg Med Chem. 2008 Feb 1;16(3):1279-86. DMKDMPL RU https://pubmed.ncbi.nlm.nih.gov/17981041 DMKCUY6 DI DMKCUY6 DMKCUY6 DN Salvinorin B propoxymethyl ether DMKCUY6 MI TTQW87Y DMKCUY6 MN Opioid receptor kappa (OPRK1) DMKCUY6 MT DTT DMKCUY6 MA Inhibitor DMKCUY6 RN Standard protecting groups create potent and selective kappa opioids: salvinorin B alkoxymethyl ethers. Bioorg Med Chem. 2008 Feb 1;16(3):1279-86. DMKCUY6 RU https://pubmed.ncbi.nlm.nih.gov/17981041 DM8H6AT DI DM8H6AT DM8H6AT DN Salvinorin B tert-butoxymethyl ether DM8H6AT MI TTQW87Y DM8H6AT MN Opioid receptor kappa (OPRK1) DM8H6AT MT DTT DM8H6AT MA Inhibitor DM8H6AT RN Standard protecting groups create potent and selective kappa opioids: salvinorin B alkoxymethyl ethers. Bioorg Med Chem. 2008 Feb 1;16(3):1279-86. DM8H6AT RU https://pubmed.ncbi.nlm.nih.gov/17981041 DM3UPAE DI DM3UPAE DM3UPAE DN Salvinorin B tetrahydropyran-2-yl ether DM3UPAE MI TTQW87Y DM3UPAE MN Opioid receptor kappa (OPRK1) DM3UPAE MT DTT DM3UPAE MA Inhibitor DM3UPAE RN Standard protecting groups create potent and selective kappa opioids: salvinorin B alkoxymethyl ethers. Bioorg Med Chem. 2008 Feb 1;16(3):1279-86. DM3UPAE RU https://pubmed.ncbi.nlm.nih.gov/17981041 DMTRMX8 DI DMTRMX8 DMTRMX8 DN Sanfetrinem cilexetil DMTRMX8 MI TTJP4SM DMTRMX8 MN Bacterial Penicillin binding protein (Bact PBP) DMTRMX8 MT DTT DMTRMX8 MA Modulator DMTRMX8 RN Entry of Sanfetrinem into Human Polymorphonuclear Granulocytes and Its Cell-Associated Activity against Intracellular, Penicillin-Resistant Streptococcus pneumoniae DMTRMX8 RU https://www.ncbi.nlm.nih.gov/pmc/articles/PMC105677 DMSF5DW DI DMSF5DW DMSF5DW DN Sanggenon C DMSF5DW MI TTELIN2 DMSF5DW MN PTPN1 messenger RNA (PTPN1 mRNA) DMSF5DW MT DTT DMSF5DW MA Inhibitor DMSF5DW RN Protein tyrosine phosphatase 1B inhibitors from Morus root bark. Bioorg Med Chem Lett. 2006 Mar 1;16(5):1426-9. DMSF5DW RU https://pubmed.ncbi.nlm.nih.gov/16356713 DMNHUOD DI DMNHUOD DMNHUOD DN Sanggenon G DMNHUOD MI TTELIN2 DMNHUOD MN PTPN1 messenger RNA (PTPN1 mRNA) DMNHUOD MT DTT DMNHUOD MA Inhibitor DMNHUOD RN Protein tyrosine phosphatase 1B inhibitors from Morus root bark. Bioorg Med Chem Lett. 2006 Mar 1;16(5):1426-9. DMNHUOD RU https://pubmed.ncbi.nlm.nih.gov/16356713 DM9XV16 DI DM9XV16 DM9XV16 DN Sanguiin H-6 DM9XV16 MI TTE14XG DM9XV16 MN Squalene monooxygenase (SQLE) DM9XV16 MT DTT DM9XV16 MA Inhibitor DM9XV16 RN Ellagitannins and hexahydroxydiphenoyl esters as inhibitors of vertebrate squalene epoxidase. J Nat Prod. 2001 Aug;64(8):1010-4. DM9XV16 RU https://pubmed.ncbi.nlm.nih.gov/11520216 DM9CV4P DI DM9CV4P DM9CV4P DN Sant7 DM9CV4P MI TT0E5SK DM9CV4P MN Interleukin 6 receptor (IL6R) DM9CV4P MT DTT DM9CV4P MA Antagonist DM9CV4P RN Emerging therapies for multiple myeloma. Expert Opin Emerg Drugs. 2009 Mar;14(1):99-127. DM9CV4P RU https://pubmed.ncbi.nlm.nih.gov/19249983 DMFAM7P DI DMFAM7P DMFAM7P DN santacruzamate A DMFAM7P MI TTSHTOI DMFAM7P MN Histone deacetylase 2 (HDAC2) DMFAM7P MT DTT DMFAM7P MA Inhibitor DMFAM7P RN Santacruzamate A, a potent and selective histone deacetylase inhibitor from the Panamanian marine cyanobacterium cf. Symploca sp. J Nat Prod. 2013 Nov 22;76(11):2026-33. DMFAM7P RU https://pubmed.ncbi.nlm.nih.gov/24164245 DMFAM7P DI DMFAM7P DMFAM7P DN santacruzamate A DMFAM7P MI TTTQGH8 DMFAM7P MN Histone deacetylase 4 (HDAC4) DMFAM7P MT DTT DMFAM7P MA Inhibitor DMFAM7P RN Santacruzamate A, a potent and selective histone deacetylase inhibitor from the Panamanian marine cyanobacterium cf. Symploca sp. J Nat Prod. 2013 Nov 22;76(11):2026-33. DMFAM7P RU https://pubmed.ncbi.nlm.nih.gov/24164245 DMFAM7P DI DMFAM7P DMFAM7P DN santacruzamate A DMFAM7P MI TT5ZKDI DMFAM7P MN Histone deacetylase 6 (HDAC6) DMFAM7P MT DTT DMFAM7P MA Inhibitor DMFAM7P RN Santacruzamate A, a potent and selective histone deacetylase inhibitor from the Panamanian marine cyanobacterium cf. Symploca sp. J Nat Prod. 2013 Nov 22;76(11):2026-33. DMFAM7P RU https://pubmed.ncbi.nlm.nih.gov/24164245 DMYZFNH DI DMYZFNH DMYZFNH DN Sapanisertib DMYZFNH MI TT7HQAF DMYZFNH MN HUMAN mammalian target of rapamycin (mTOR) DMYZFNH MT DTT DMYZFNH MA Inhibitor DMYZFNH RN Prevent COVID-19 Severity by Repurposing mTOR Inhibitors. 2 April 2020 DMYZFNH RU https://www.preprints.org/manuscript/202004.0060/v1 DM6GE21 DI DM6GE21 DM6GE21 DN Sapropterin DM6GE21 MI DER6XYF DM6GE21 MN Tryptophan 5-hydroxylase 2 (TPH2) DM6GE21 MT DME DM6GE21 MA Metabolism DM6GE21 RN Characterization of wild-type and mutant forms of human tryptophan hydroxylase 2. J Neurochem. 2007 Mar;100(6):1648-57. DM6GE21 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=17181551 DM2J0UN DI DM2J0UN DM2J0UN DN SAR-106881 DM2J0UN MI TTRLW2X DM2J0UN MN Fibroblast growth factor receptor 1 (FGFR1) DM2J0UN MT DTT DM2J0UN MA Agonist DM2J0UN RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1808). DM2J0UN RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1808 DMSYE4W DI DMSYE4W DMSYE4W DN SAR-131675 DMSYE4W MI TTDCBX5 DMSYE4W MN Vascular endothelial growth factor receptor 3 (FLT-4) DMSYE4W MT DTT DMSYE4W MA Inhibitor DMSYE4W RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1814). DMSYE4W RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1814 DM0RDC4 DI DM0RDC4 DM0RDC4 DN Sarafotoxin 6C DM0RDC4 MI TT3ZTGU DM0RDC4 MN Endothelin B receptor (EDNRB) DM0RDC4 MT DTT DM0RDC4 MA Antagonist DM0RDC4 RN Human optic nerve head astrocytes as a target for endothelin-1. Invest Ophthalmol Vis Sci. 2002 Aug;43(8):2704-13. DM0RDC4 RU https://pubmed.ncbi.nlm.nih.gov/12147606 DMR6PJ5 DI DMR6PJ5 DMR6PJ5 DN sarafotoxin S6b DMR6PJ5 MI TTKRD0G DMR6PJ5 MN Endothelin A receptor (EDNRA) DMR6PJ5 MT DTT DMR6PJ5 MA Agonist DMR6PJ5 RN ETA receptor-mediated constrictor responses to endothelin peptides in human blood vessels in vitro. Br J Pharmacol. 1995 May;115(1):191-7. DMR6PJ5 RU https://pubmed.ncbi.nlm.nih.gov/7647976 DMCNOJV DI DMCNOJV DMCNOJV DN Sar-Arg-Val-Tyr-Ile-His-Pro-Ala DMCNOJV MI TTQVOEI DMCNOJV MN Angiotensin II receptor type-2 (AGTR2) DMCNOJV MT DTT DMCNOJV MA Inhibitor DMCNOJV RN Synthesis and structure-activity relationships of a novel series of non-peptide angiotensin II receptor binding inhibitors specific for the AT2 sub... J Med Chem. 1991 Nov;34(11):3248-60. DMCNOJV RU https://pubmed.ncbi.nlm.nih.gov/1956044 DMS0FQC DI DMS0FQC DMS0FQC DN Sar-Arg-Val-Tyr-Ile-His-Pro-Ile DMS0FQC MI TTQVOEI DMS0FQC MN Angiotensin II receptor type-2 (AGTR2) DMS0FQC MT DTT DMS0FQC MA Inhibitor DMS0FQC RN Synthesis and structure-activity relationships of a novel series of non-peptide angiotensin II receptor binding inhibitors specific for the AT2 sub... J Med Chem. 1991 Nov;34(11):3248-60. DMS0FQC RU https://pubmed.ncbi.nlm.nih.gov/1956044 DMD6SJT DI DMD6SJT DMD6SJT DN Sar-Arg-Val-Tyr-Ile-His-Pro-Phe-OH DMD6SJT MI TTQVOEI DMD6SJT MN Angiotensin II receptor type-2 (AGTR2) DMD6SJT MT DTT DMD6SJT MA Inhibitor DMD6SJT RN 1-(carboxybenzyl)imidazole-5-acrylic acids: potent and selective angiotensin II receptor antagonists. J Med Chem. 1991 Apr;34(4):1514-7. DMD6SJT RU https://pubmed.ncbi.nlm.nih.gov/2016730 DMZR4FX DI DMZR4FX DMZR4FX DN Sarcodictyin A DMZR4FX MI TTML2WA DMZR4FX MN Tubulin (TUB) DMZR4FX MT DTT DMZR4FX MA Inducer DMZR4FX RN The coral-derived natural products eleutherobin and sarcodictyins A and B: effects on the assembly of purified tubulin with and without microtubule-associated proteins and binding at the polymer taxoid site. Biochemistry. 1999 Apr 27;38(17):5490-8. DMZR4FX RU https://pubmed.ncbi.nlm.nih.gov/10220336 DMIVGOR DI DMIVGOR DMIVGOR DN Sarcosine DMIVGOR MI DT2CFQ5 DMIVGOR MN Sodium- and chloride-dependent glycine transporter 1 (SLC6A9) DMIVGOR MT DTP DMIVGOR MA Substrate DMIVGOR RN Glycine is taken up through GLYT1 and GLYT2 transporters into mouse spinal cord axon terminals and causes vesicular and carrier-mediated release of its proposed co-transmitter GABA. J Neurochem. 2001 Mar;76(6):1823-32. DMIVGOR RU http://www.ncbi.nlm.nih.gov/pubmed/11259500 DMILBO9 DI DMILBO9 DMILBO9 DN SARMs DMILBO9 MI TTS64P2 DMILBO9 MN Androgen receptor (AR) DMILBO9 MT DTT DMILBO9 MA Modulator DMILBO9 RN The ChEMBL database in 2017. Nucleic Acids Res. 2017 Jan 4;45(D1):D945-D954. DMILBO9 RU https://www.ncbi.nlm.nih.gov/pubmed/27899562 DMJQVAG DI DMJQVAG DMJQVAG DN S-ATPO DMJQVAG MI TT0MYE2 DMJQVAG MN Glutamate receptor ionotropic kainate 1 (GRIK1) DMJQVAG MT DTT DMJQVAG MA Inhibitor DMJQVAG RN 3-Substituted phenylalanines as selective AMPA- and kainate receptor ligands. Bioorg Med Chem. 2009 Sep 1;17(17):6390-401. DMJQVAG RU https://pubmed.ncbi.nlm.nih.gov/19656686 DMF8O62 DI DMF8O62 DMF8O62 DN SAVX-1 DMF8O62 MI TT2JWF6 DMF8O62 MN Peroxisome proliferator-activated receptor delta (PPARD) DMF8O62 MT DTT DMF8O62 MA Modulator DMF8O62 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 594). DMF8O62 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=594 DMLX8RW DI DMLX8RW DMLX8RW DN Saxitoxin DMLX8RW MI TTRK8B9 DMLX8RW MN Sodium channel unspecific (NaC) DMLX8RW MT DTT DMLX8RW MA Blocker DMLX8RW RN Effect of neurotoxins on the electrical activity and contraction of the heart muscle. C R Seances Soc Biol Fil. 1997;191(3):451-71. DMLX8RW RU https://pubmed.ncbi.nlm.nih.gov/9295968 DM68JI5 DI DM68JI5 DM68JI5 DN Sazetidine-A DM68JI5 MI TTWNV8U DM68JI5 MN Nicotinic acid receptor (HCAR2) DM68JI5 MT DTT DM68JI5 MA Binder DM68JI5 RN Discovery of SCH 900271, a Potent Nicotinic Acid Receptor Agonist for the Treatment of Dyslipidemia. ACS Med Chem Lett. 2011 Nov 24;3(1):63-8. DM68JI5 RU https://pubmed.ncbi.nlm.nih.gov/24900372 DMQAO5B DI DMQAO5B DMQAO5B DN SB 203106 DMQAO5B MI TT85JO3 DMQAO5B MN 5-HT receptor (5HTR) DMQAO5B MT DTT DMQAO5B MA Antagonist DMQAO5B RN 5-Hydroxytryptamine mediated contractions in isolated preparations of equine ileum and pelvic flexure: pharmacological characterization of a new 5-HT(4) agonist. J Vet Pharmacol Ther. 2002 Feb;25(1):49-58. DMQAO5B RU https://pubmed.ncbi.nlm.nih.gov/11874527 DM43K85 DI DM43K85 DM43K85 DN SB 204070 DM43K85 MI TT07C3Y DM43K85 MN 5-HT 4 receptor (HTR4) DM43K85 MT DTT DM43K85 MA Antagonist DM43K85 RN [3H]RS 57639, a high affinity, selective 5-HT4 receptor partial agonist, specifically labels guinea-pig striatal and rat cloned (5-HT4S and 5-HT4L) receptors. Neuropharmacology. 1997 Apr-May;36(4-5):671-9. DM43K85 RU https://pubmed.ncbi.nlm.nih.gov/9225293 DM3LQF4 DI DM3LQF4 DM3LQF4 DN SB 204741 DM3LQF4 MI TT0K1SC DM3LQF4 MN 5-HT 2B receptor (HTR2B) DM3LQF4 MT DTT DM3LQF4 MA Antagonist DM3LQF4 RN Pharmacological characterisation of the agonist radioligand binding site of 5-HT(2A), 5-HT(2B) and 5-HT(2C) receptors. Naunyn Schmiedebergs Arch Pharmacol. 2004 Aug;370(2):114-23. DM3LQF4 RU https://pubmed.ncbi.nlm.nih.gov/15322733 DM3LQF4 DI DM3LQF4 DM3LQF4 DN SB 204741 DM3LQF4 MI TTWJBZ5 DM3LQF4 MN 5-HT 2C receptor (HTR2C) DM3LQF4 MT DTT DM3LQF4 MA Antagonist DM3LQF4 RN Pharmacological characterisation of the agonist radioligand binding site of 5-HT(2A), 5-HT(2B) and 5-HT(2C) receptors. Naunyn Schmiedebergs Arch Pharmacol. 2004 Aug;370(2):114-23. DM3LQF4 RU https://pubmed.ncbi.nlm.nih.gov/15322733 DMCM4LT DI DMCM4LT DMCM4LT DN SB 215505 DMCM4LT MI TTJQOD7 DMCM4LT MN 5-HT 2A receptor (HTR2A) DMCM4LT MT DTT DMCM4LT MA Antagonist DMCM4LT RN Attenuation of haloperidol-induced catalepsy by a 5-HT2C receptor antagonist. Br J Pharmacol. 1999 Feb;126(3):572-4. DMCM4LT RU https://pubmed.ncbi.nlm.nih.gov/10188965 DMCM4LT DI DMCM4LT DMCM4LT DN SB 215505 DMCM4LT MI TT0K1SC DMCM4LT MN 5-HT 2B receptor (HTR2B) DMCM4LT MT DTT DMCM4LT MA Antagonist DMCM4LT RN Attenuation of haloperidol-induced catalepsy by a 5-HT2C receptor antagonist. Br J Pharmacol. 1999 Feb;126(3):572-4. DMCM4LT RU https://pubmed.ncbi.nlm.nih.gov/10188965 DMCM4LT DI DMCM4LT DMCM4LT DN SB 215505 DMCM4LT MI TTWJBZ5 DMCM4LT MN 5-HT 2C receptor (HTR2C) DMCM4LT MT DTT DMCM4LT MA Antagonist DMCM4LT RN Attenuation of haloperidol-induced catalepsy by a 5-HT2C receptor antagonist. Br J Pharmacol. 1999 Feb;126(3):572-4. DMCM4LT RU https://pubmed.ncbi.nlm.nih.gov/10188965 DMB3R4Z DI DMB3R4Z DMB3R4Z DN SB 216641 DMB3R4Z MI TTSQIFT DMB3R4Z MN 5-HT 1A receptor (HTR1A) DMB3R4Z MT DTT DMB3R4Z MA Agonist DMB3R4Z RN SB-216641 and BRL-15572--compounds to pharmacologically discriminate h5-HT1B and h5-HT1D receptors. Naunyn Schmiedebergs Arch Pharmacol. 1997 Sep;356(3):312-20. DMB3R4Z RU https://pubmed.ncbi.nlm.nih.gov/9303567 DMB3R4Z DI DMB3R4Z DMB3R4Z DN SB 216641 DMB3R4Z MI TTK8CXU DMB3R4Z MN 5-HT 1B receptor (HTR1B) DMB3R4Z MT DTT DMB3R4Z MA Agonist DMB3R4Z RN SB-216641 and BRL-15572--compounds to pharmacologically discriminate h5-HT1B and h5-HT1D receptors. Naunyn Schmiedebergs Arch Pharmacol. 1997 Sep;356(3):312-20. DMB3R4Z RU https://pubmed.ncbi.nlm.nih.gov/9303567 DMB3R4Z DI DMB3R4Z DMB3R4Z DN SB 216641 DMB3R4Z MI TT6MSOK DMB3R4Z MN 5-HT 1D receptor (HTR1D) DMB3R4Z MT DTT DMB3R4Z MA Agonist DMB3R4Z RN SB-216641 and BRL-15572--compounds to pharmacologically discriminate h5-HT1B and h5-HT1D receptors. Naunyn Schmiedebergs Arch Pharmacol. 1997 Sep;356(3):312-20. DMB3R4Z RU https://pubmed.ncbi.nlm.nih.gov/9303567 DMB3R4Z DI DMB3R4Z DMB3R4Z DN SB 216641 DMB3R4Z MI TTJQOD7 DMB3R4Z MN 5-HT 2A receptor (HTR2A) DMB3R4Z MT DTT DMB3R4Z MA Agonist DMB3R4Z RN SB-216641 and BRL-15572--compounds to pharmacologically discriminate h5-HT1B and h5-HT1D receptors. Naunyn Schmiedebergs Arch Pharmacol. 1997 Sep;356(3):312-20. DMB3R4Z RU https://pubmed.ncbi.nlm.nih.gov/9303567 DMB3R4Z DI DMB3R4Z DMB3R4Z DN SB 216641 DMB3R4Z MI TT0K1SC DMB3R4Z MN 5-HT 2B receptor (HTR2B) DMB3R4Z MT DTT DMB3R4Z MA Agonist DMB3R4Z RN SB-216641 and BRL-15572--compounds to pharmacologically discriminate h5-HT1B and h5-HT1D receptors. Naunyn Schmiedebergs Arch Pharmacol. 1997 Sep;356(3):312-20. DMB3R4Z RU https://pubmed.ncbi.nlm.nih.gov/9303567 DMB3R4Z DI DMB3R4Z DMB3R4Z DN SB 216641 DMB3R4Z MI TTWJBZ5 DMB3R4Z MN 5-HT 2C receptor (HTR2C) DMB3R4Z MT DTT DMB3R4Z MA Agonist DMB3R4Z RN SB-216641 and BRL-15572--compounds to pharmacologically discriminate h5-HT1B and h5-HT1D receptors. Naunyn Schmiedebergs Arch Pharmacol. 1997 Sep;356(3):312-20. DMB3R4Z RU https://pubmed.ncbi.nlm.nih.gov/9303567 DMN1G5S DI DMN1G5S DMN1G5S DN SB 218078 DMN1G5S MI TTTU902 DMN1G5S MN Checkpoint kinase-1 (CHK1) DMN1G5S MT DTT DMN1G5S MA Inhibitor DMN1G5S RN An indolocarbazole inhibitor of human checkpoint kinase (Chk1) abrogates cell cycle arrest caused by DNA damage. Cancer Res. 2000 Feb 1;60(3):566-72. DMN1G5S RU https://pubmed.ncbi.nlm.nih.gov/10676638 DM8DVY2 DI DM8DVY2 DM8DVY2 DN SB 221284 DM8DVY2 MI TTJQOD7 DM8DVY2 MN 5-HT 2A receptor (HTR2A) DM8DVY2 MT DTT DM8DVY2 MA Antagonist DM8DVY2 RN Pharmacological characterisation of the agonist radioligand binding site of 5-HT(2A), 5-HT(2B) and 5-HT(2C) receptors. Naunyn Schmiedebergs Arch Pharmacol. 2004 Aug;370(2):114-23. DM8DVY2 RU https://pubmed.ncbi.nlm.nih.gov/15322733 DM8DVY2 DI DM8DVY2 DM8DVY2 DN SB 221284 DM8DVY2 MI TT0K1SC DM8DVY2 MN 5-HT 2B receptor (HTR2B) DM8DVY2 MT DTT DM8DVY2 MA Antagonist DM8DVY2 RN Pharmacological characterisation of the agonist radioligand binding site of 5-HT(2A), 5-HT(2B) and 5-HT(2C) receptors. Naunyn Schmiedebergs Arch Pharmacol. 2004 Aug;370(2):114-23. DM8DVY2 RU https://pubmed.ncbi.nlm.nih.gov/15322733 DM8DVY2 DI DM8DVY2 DM8DVY2 DN SB 221284 DM8DVY2 MI TTWJBZ5 DM8DVY2 MN 5-HT 2C receptor (HTR2C) DM8DVY2 MT DTT DM8DVY2 MA Antagonist DM8DVY2 RN Pharmacological characterisation of the agonist radioligand binding site of 5-HT(2A), 5-HT(2B) and 5-HT(2C) receptors. Naunyn Schmiedebergs Arch Pharmacol. 2004 Aug;370(2):114-23. DM8DVY2 RU https://pubmed.ncbi.nlm.nih.gov/15322733 DMIS8JQ DI DMIS8JQ DMIS8JQ DN SB 224289 DMIS8JQ MI TTK8CXU DMIS8JQ MN 5-HT 1B receptor (HTR1B) DMIS8JQ MT DTT DMIS8JQ MA Antagonist DMIS8JQ RN 5-hydroxytryptamine receptors mediating contraction in human small muscular pulmonary arteries: importance of the 5-HT1B receptor. Br J Pharmacol. 1999 Oct;128(3):730-4. DMIS8JQ RU https://pubmed.ncbi.nlm.nih.gov/10516655 DM7S63O DI DM7S63O DM7S63O DN SB 227122 DM7S63O MI TT27RFC DM7S63O MN Opioid receptor delta (OPRD1) DM7S63O MT DTT DM7S63O MA Agonist DM7S63O RN The antitussive activity of delta-opioid receptor stimulation in guinea pigs. J Pharmacol Exp Ther. 2000 Feb;292(2):803-9. DM7S63O RU https://pubmed.ncbi.nlm.nih.gov/10640321 DMKA8R4 DI DMKA8R4 DMKA8R4 DN SB 228357 DMKA8R4 MI TTJQOD7 DMKA8R4 MN 5-HT 2A receptor (HTR2A) DMKA8R4 MT DTT DMKA8R4 MA Antagonist DMKA8R4 RN Biarylcarbamoylindolines are novel and selective 5-HT(2C) receptor inverse agonists: identification of 5-methyl-1-[[2-[(2-methyl-3-pyridyl)oxy]- 5-pyridyl]carbamoyl]-6-trifluoromethylindoline (SB-243213) as a potential antidepressant/anxiolytic agent. J Med Chem. 2000 Mar 23;43(6):1123-34. DMKA8R4 RU https://pubmed.ncbi.nlm.nih.gov/10737744 DMKA8R4 DI DMKA8R4 DMKA8R4 DN SB 228357 DMKA8R4 MI TT0K1SC DMKA8R4 MN 5-HT 2B receptor (HTR2B) DMKA8R4 MT DTT DMKA8R4 MA Antagonist DMKA8R4 RN Biarylcarbamoylindolines are novel and selective 5-HT(2C) receptor inverse agonists: identification of 5-methyl-1-[[2-[(2-methyl-3-pyridyl)oxy]- 5-pyridyl]carbamoyl]-6-trifluoromethylindoline (SB-243213) as a potential antidepressant/anxiolytic agent. J Med Chem. 2000 Mar 23;43(6):1123-34. DMKA8R4 RU https://pubmed.ncbi.nlm.nih.gov/10737744 DMKA8R4 DI DMKA8R4 DMKA8R4 DN SB 228357 DMKA8R4 MI TTWJBZ5 DMKA8R4 MN 5-HT 2C receptor (HTR2C) DMKA8R4 MT DTT DMKA8R4 MA Antagonist DMKA8R4 RN Biarylcarbamoylindolines are novel and selective 5-HT(2C) receptor inverse agonists: identification of 5-methyl-1-[[2-[(2-methyl-3-pyridyl)oxy]- 5-pyridyl]carbamoyl]-6-trifluoromethylindoline (SB-243213) as a potential antidepressant/anxiolytic agent. J Med Chem. 2000 Mar 23;43(6):1123-34. DMKA8R4 RU https://pubmed.ncbi.nlm.nih.gov/10737744 DM201Q7 DI DM201Q7 DM201Q7 DN SB 239063 DM201Q7 MI TTVKILB DM201Q7 MN Prostaglandin G/H synthase 2 (COX-2) DM201Q7 MT DTT DM201Q7 MA Inhibitor DM201Q7 RN SB-239063, a potent and selective inhibitor of p38 map kinase: preclinical pharmacokinetics and species-specific reversible isomerization. Pharm Res. 2001 Sep;18(9):1336-44. DM201Q7 RU https://pubmed.ncbi.nlm.nih.gov/11683250 DMISBDC DI DMISBDC DMISBDC DN SB 242084 DMISBDC MI TTJQOD7 DMISBDC MN 5-HT 2A receptor (HTR2A) DMISBDC MT DTT DMISBDC MA Antagonist DMISBDC RN SB 242084, a selective and brain penetrant 5-HT2C receptor antagonist. Neuropharmacology. 1997 Apr-May;36(4-5):609-20. DMISBDC RU https://pubmed.ncbi.nlm.nih.gov/9225286 DMISBDC DI DMISBDC DMISBDC DN SB 242084 DMISBDC MI TT0K1SC DMISBDC MN 5-HT 2B receptor (HTR2B) DMISBDC MT DTT DMISBDC MA Antagonist DMISBDC RN SB 242084, a selective and brain penetrant 5-HT2C receptor antagonist. Neuropharmacology. 1997 Apr-May;36(4-5):609-20. DMISBDC RU https://pubmed.ncbi.nlm.nih.gov/9225286 DMISBDC DI DMISBDC DMISBDC DN SB 242084 DMISBDC MI TTWJBZ5 DMISBDC MN 5-HT 2C receptor (HTR2C) DMISBDC MT DTT DMISBDC MA Antagonist DMISBDC RN SB 242084, a selective and brain penetrant 5-HT2C receptor antagonist. Neuropharmacology. 1997 Apr-May;36(4-5):609-20. DMISBDC RU https://pubmed.ncbi.nlm.nih.gov/9225286 DMAFWRT DI DMAFWRT DMAFWRT DN SB 243213 DMAFWRT MI TTWJBZ5 DMAFWRT MN 5-HT 2C receptor (HTR2C) DMAFWRT MT DTT DMAFWRT MA Agonist DMAFWRT RN SB-243213; a selective 5-HT2C receptor inverse agonist with improved anxiolytic profile: lack of tolerance and withdrawal anxiety. Neuropharmacology. 2001 Aug;41(2):186-99. DMAFWRT RU https://pubmed.ncbi.nlm.nih.gov/11489455 DM2QJKZ DI DM2QJKZ DM2QJKZ DN SB 258585 DM2QJKZ MI TTJS8PY DM2QJKZ MN 5-HT 6 receptor (HTR6) DM2QJKZ MT DTT DM2QJKZ MA Antagonist DM2QJKZ RN 5-HT6 receptor binding sites in schizophrenia and following antipsychotic drug administration: autoradiographic studies with [125I]SB-258585. Synapse. 2002 Sep 1;45(3):191-9. DM2QJKZ RU https://pubmed.ncbi.nlm.nih.gov/12112397 DMFHUGC DI DMFHUGC DMFHUGC DN SB 269970-A DMFHUGC MI TTO9X1H DMFHUGC MN 5-HT 7 receptor (HTR7) DMFHUGC MT DTT DMFHUGC MA Antagonist DMFHUGC RN 5-HT7 receptors. Curr Drug Targets CNS Neurol Disord. 2004 Feb;3(1):81-90. DMFHUGC RU https://pubmed.ncbi.nlm.nih.gov/14965246 DMOLNQX DI DMOLNQX DMOLNQX DN SB 272183 DMOLNQX MI TTSQIFT DMOLNQX MN 5-HT 1A receptor (HTR1A) DMOLNQX MT DTT DMOLNQX MA Antagonist DMOLNQX RN SB-272183, a selective 5-HT(1A), 5-HT(1B) and 5-HT(1D) receptor antagonist in native tissue. Br J Pharmacol. 2001 Jul;133(6):797-806. DMOLNQX RU https://pubmed.ncbi.nlm.nih.gov/11454652 DMOLNQX DI DMOLNQX DMOLNQX DN SB 272183 DMOLNQX MI TTK8CXU DMOLNQX MN 5-HT 1B receptor (HTR1B) DMOLNQX MT DTT DMOLNQX MA Antagonist DMOLNQX RN SB-272183, a selective 5-HT(1A), 5-HT(1B) and 5-HT(1D) receptor antagonist in native tissue. Br J Pharmacol. 2001 Jul;133(6):797-806. DMOLNQX RU https://pubmed.ncbi.nlm.nih.gov/11454652 DMOLNQX DI DMOLNQX DMOLNQX DN SB 272183 DMOLNQX MI TT6MSOK DMOLNQX MN 5-HT 1D receptor (HTR1D) DMOLNQX MT DTT DMOLNQX MA Antagonist DMOLNQX RN SB-272183, a selective 5-HT(1A), 5-HT(1B) and 5-HT(1D) receptor antagonist in native tissue. Br J Pharmacol. 2001 Jul;133(6):797-806. DMOLNQX RU https://pubmed.ncbi.nlm.nih.gov/11454652 DMVO8P5 DI DMVO8P5 DMVO8P5 DN SB 272844 DMVO8P5 MI TT30C9G DMVO8P5 MN C-X-C chemokine receptor type 2 (CXCR2) DMVO8P5 MT DTT DMVO8P5 MA Antagonist DMVO8P5 RN The selective CXCR2 antagonist SB272844 blocks interleukin-8 and growth-related oncogene-alpha-mediated inhibition of spontaneous neutrophil apoptosis. Pulm Pharmacol Ther. 2002;15(2):103-10. DMVO8P5 RU https://pubmed.ncbi.nlm.nih.gov/12090783 DM21Z6H DI DM21Z6H DM21Z6H DN SB 649915 DM21Z6H MI TTSQIFT DM21Z6H MN 5-HT 1A receptor (HTR1A) DM21Z6H MT DTT DM21Z6H MA Antagonist DM21Z6H RN Discovery of the first potent, selective 5-hydroxytryptamine1D receptor antagonist. J Med Chem. 2005 May 19;48(10):3478-80. DM21Z6H RU https://pubmed.ncbi.nlm.nih.gov/15887956 DM21Z6H DI DM21Z6H DM21Z6H DN SB 649915 DM21Z6H MI TTK8CXU DM21Z6H MN 5-HT 1B receptor (HTR1B) DM21Z6H MT DTT DM21Z6H MA Antagonist DM21Z6H RN Discovery of the first potent, selective 5-hydroxytryptamine1D receptor antagonist. J Med Chem. 2005 May 19;48(10):3478-80. DM21Z6H RU https://pubmed.ncbi.nlm.nih.gov/15887956 DM21Z6H DI DM21Z6H DM21Z6H DN SB 649915 DM21Z6H MI TT6MSOK DM21Z6H MN 5-HT 1D receptor (HTR1D) DM21Z6H MT DTT DM21Z6H MA Antagonist DM21Z6H RN Discovery of the first potent, selective 5-hydroxytryptamine1D receptor antagonist. J Med Chem. 2005 May 19;48(10):3478-80. DM21Z6H RU https://pubmed.ncbi.nlm.nih.gov/15887956 DM82GH9 DI DM82GH9 DM82GH9 DN SB 699551 DM82GH9 MI TTRUFDT DM82GH9 MN 5-HT 5A receptor (HTR5A) DM82GH9 MT DTT DM82GH9 MA Antagonist DM82GH9 RN Discovery of a potent and selective 5-ht5A receptor antagonist by high-throughput chemistry. Bioorg Med Chem Lett. 2005 Sep 15;15(18):4014-8. DM82GH9 RU https://pubmed.ncbi.nlm.nih.gov/16002289 DMGHRY0 DI DMGHRY0 DMGHRY0 DN SB 714786 DMGHRY0 MI TTSQIFT DMGHRY0 MN 5-HT 1A receptor (HTR1A) DMGHRY0 MT DTT DMGHRY0 MA Antagonist DMGHRY0 RN Discovery of the first potent, selective 5-hydroxytryptamine1D receptor antagonist. J Med Chem. 2005 May 19;48(10):3478-80. DMGHRY0 RU https://pubmed.ncbi.nlm.nih.gov/15887956 DMGHRY0 DI DMGHRY0 DMGHRY0 DN SB 714786 DMGHRY0 MI TTK8CXU DMGHRY0 MN 5-HT 1B receptor (HTR1B) DMGHRY0 MT DTT DMGHRY0 MA Antagonist DMGHRY0 RN Discovery of the first potent, selective 5-hydroxytryptamine1D receptor antagonist. J Med Chem. 2005 May 19;48(10):3478-80. DMGHRY0 RU https://pubmed.ncbi.nlm.nih.gov/15887956 DMGHRY0 DI DMGHRY0 DMGHRY0 DN SB 714786 DMGHRY0 MI TT6MSOK DMGHRY0 MN 5-HT 1D receptor (HTR1D) DMGHRY0 MT DTT DMGHRY0 MA Antagonist DMGHRY0 RN Discovery of the first potent, selective 5-hydroxytryptamine1D receptor antagonist. J Med Chem. 2005 May 19;48(10):3478-80. DMGHRY0 RU https://pubmed.ncbi.nlm.nih.gov/15887956 DMOZX0D DI DMOZX0D DMOZX0D DN SB-0304 DMOZX0D MI TT27RFC DMOZX0D MN Opioid receptor delta (OPRD1) DMOZX0D MT DTT DMOZX0D MA Inhibitor DMOZX0D RN Blood-brain barrier penetration by two dermorphin tetrapeptide analogues: role of lipophilicity vs structural flexibility. J Med Chem. 2008 Apr 24;51(8):2571-4. DMOZX0D RU https://pubmed.ncbi.nlm.nih.gov/18370374 DMOZX0D DI DMOZX0D DMOZX0D DN SB-0304 DMOZX0D MI TTKWM86 DMOZX0D MN Opioid receptor mu (MOP) DMOZX0D MT DTT DMOZX0D MA Inhibitor DMOZX0D RN Blood-brain barrier penetration by two dermorphin tetrapeptide analogues: role of lipophilicity vs structural flexibility. J Med Chem. 2008 Apr 24;51(8):2571-4. DMOZX0D RU https://pubmed.ncbi.nlm.nih.gov/18370374 DM9O0AR DI DM9O0AR DM9O0AR DN SB-13 DM9O0AR MI TTE4KHA DM9O0AR MN Amyloid beta A4 protein (APP) DM9O0AR MT DTT DM9O0AR MA Inhibitor DM9O0AR RN Synthesis of biphenyltrienes as probes for beta-amyloid plaques. J Med Chem. 2006 May 4;49(9):2841-4. DM9O0AR RU https://pubmed.ncbi.nlm.nih.gov/16640346 DMKLWSG DI DMKLWSG DMKLWSG DN SB-201076 DMKLWSG MI TT0Z6Y2 DMKLWSG MN ATP-citrate synthase (ACLY) DMKLWSG MT DTT DMKLWSG MA Inhibitor DMKLWSG RN The biology and chemistry of hyperlipidemia. Bioorg Med Chem. 2007 Jul 15;15(14):4674-99. DMKLWSG RU https://pubmed.ncbi.nlm.nih.gov/17521912 DM09UIS DI DM09UIS DM09UIS DN SB-202235 DM09UIS MI TT2J34L DM09UIS MN Arachidonate 5-lipoxygenase (5-LOX) DM09UIS MT DTT DM09UIS MA Modulator DM09UIS RN Pharmacological characterization of SB 202235, a potent and selective 5-lipoxygenase inhibitor: effects in models of allergic asthma. J Pharmacol Exp Ther. 1995 Jun;273(3):1147-55. DM09UIS RU https://www.ncbi.nlm.nih.gov/pubmed/7791085 DM3AWMF DI DM3AWMF DM3AWMF DN SB-203347 DM3AWMF MI TT9V5JH DM3AWMF MN Phospholipase A2 (PLA2G1B) DM3AWMF MT DTT DM3AWMF MA Modulator DM3AWMF RN SB 203347, an inhibitor of 14 kDa phospholipase A2, alters human neutrophil arachidonic acid release and metabolism and prolongs survival in murine... J Pharmacol Exp Ther. 1995 Sep;274(3):1254-62. DM3AWMF RU https://www.ncbi.nlm.nih.gov/pubmed/7562496 DM704TL DI DM704TL DM704TL DN SB-207043 DM704TL MI TTJA1ZO DM704TL MN ITGB3 messenger RNA (ITGB3 mRNA) DM704TL MT DTT DM704TL MA Inhibitor DM704TL RN Preparation and Properties of a fibrinogen receptor antagonist containing the Arg-Gly-Asp sequence and nitroxide radicals, Bioorg. Med. Chem. Lett. 3(6):1179-1184 (1993). DM704TL RU http://www.sciencedirect.com/science/article/pii/S0960894X00803108 DMVQKMC DI DMVQKMC DMVQKMC DN SB-207710 DMVQKMC MI TT07C3Y DMVQKMC MN 5-HT 4 receptor (HTR4) DMVQKMC MT DTT DMVQKMC MA Inhibitor DMVQKMC RN Synthesis, structure-affinity relationships, and radiolabeling of selective high-affinity 5-HT4 receptor ligands as prospective imaging probes for ... J Med Chem. 2010 Oct 14;53(19):7035-47. DMVQKMC RU https://pubmed.ncbi.nlm.nih.gov/20812727 DM5EWQN DI DM5EWQN DM5EWQN DN SB-210313 DM5EWQN MI TTVG215 DM5EWQN MN Debrisoquine 4-hydroxylase (CYP2D6) DM5EWQN MT DTT DM5EWQN MA Inhibitor DM5EWQN RN Pyrimidinylimidazole inhibitors of CSBP/p38 kinase demonstrating decreased inhibition of hepatic cytochrome P450 enzymes. Bioorg Med Chem Lett. 1998 Nov 17;8(22):3111-6. DM5EWQN RU https://pubmed.ncbi.nlm.nih.gov/9873686 DMUCHNP DI DMUCHNP DMUCHNP DN SB-213068 DMUCHNP MI TTT2SVW DMUCHNP MN PPAR-gamma messenger RNA (PPARG mRNA) DMUCHNP MT DTT DMUCHNP MA Inhibitor DMUCHNP RN Non thiazolidinedione antihyperglycaemic agents. 2: alpha-Carbon substituted beta-phenylpropanoic acids1, Bioorg. Med. Chem. Lett. 6(17):2127-2130 (1996). DMUCHNP RU http://www.sciencedirect.com/science/article/pii/0960894X96003824 DMH1CFX DI DMH1CFX DMH1CFX DN SB-214111 DMH1CFX MI TTJS8PY DMH1CFX MN 5-HT 6 receptor (HTR6) DMH1CFX MT DTT DMH1CFX MA Modulator DMH1CFX RN The distribution of 5-HT(6) receptors in rat brain: an autoradiographic binding study using the radiolabelled 5-HT(6) receptor antagonist [(125)I]S... Brain Res. 2002 Apr 26;934(1):49-57. DMH1CFX RU https://www.ncbi.nlm.nih.gov/pubmed/11937069 DMIYFQ5 DI DMIYFQ5 DMIYFQ5 DN SB216763 DMIYFQ5 MI TTRZQE3 DMIYFQ5 MN Glycogen synthase kinase-3 alpha (GSK-3A) DMIYFQ5 MT DTT DMIYFQ5 MA Inhibitor DMIYFQ5 RN Intracellular protein phosphorylation in eosinophils and the functional relevance in cytokine production. Int Arch Allergy Immunol. 2009;149 Suppl 1:45-50. DMIYFQ5 RU https://pubmed.ncbi.nlm.nih.gov/19494504 DMOH9TA DI DMOH9TA DMOH9TA DN SB-216995 DMOH9TA MI TTQBR95 DMOH9TA MN Stress-activated protein kinase 2a (p38 alpha) DMOH9TA MT DTT DMOH9TA MA Inhibitor DMOH9TA RN In silico search for multi-target anti-inflammatories in Chinese herbs and formulas. Bioorg Med Chem. 2010 Mar 15;18(6):2204-2218. DMOH9TA RU https://pubmed.ncbi.nlm.nih.gov/20188577 DM7LARD DI DM7LARD DM7LARD DN SB218078 DM7LARD MI TTTU902 DM7LARD MN Checkpoint kinase-1 (CHK1) DM7LARD MT DTT DM7LARD MA Inhibitor DM7LARD RN Chk1 inhibitor synergizes quinacrine mediated apoptosis in breast cancer cells by compromising the base excision repair cascade. Biochem Pharmacol. 2016 Apr 1;105:23-33. DM7LARD RU https://pubmed.ncbi.nlm.nih.gov/26850987 DMJKE4M DI DMJKE4M DMJKE4M DN SB-218655 DMJKE4M MI TTQBR95 DMJKE4M MN Stress-activated protein kinase 2a (p38 alpha) DMJKE4M MT DTT DMJKE4M MA Inhibitor DMJKE4M RN In silico search for multi-target anti-inflammatories in Chinese herbs and formulas. Bioorg Med Chem. 2010 Mar 15;18(6):2204-2218. DMJKE4M RU https://pubmed.ncbi.nlm.nih.gov/20188577 DMMWCLV DI DMMWCLV DMMWCLV DN SB-221420-A DMMWCLV MI TTN9VTF DMMWCLV MN Voltage-gated sodium channel alpha Nav1.9 (SCN11A) DMMWCLV MT DTT DMMWCLV MA Blocker DMMWCLV RN Recent updates of N-type calcium channel blockers with therapeutic potential for neuropathic pain and stroke. Curr Top Med Chem. 2009;9(4):377-95. DMMWCLV RU https://pubmed.ncbi.nlm.nih.gov/19442208 DMO1WI8 DI DMO1WI8 DMO1WI8 DN SB-227931 DMO1WI8 MI TTQBR95 DMO1WI8 MN Stress-activated protein kinase 2a (p38 alpha) DMO1WI8 MT DTT DMO1WI8 MA Inhibitor DMO1WI8 RN The neuroprotective action of JNK3 inhibitors based on the 6,7-dihydro-5H-pyrrolo[1,2-a]imidazole scaffold. Bioorg Med Chem Lett. 2005 Nov 1;15(21):4666-70. DMO1WI8 RU https://pubmed.ncbi.nlm.nih.gov/16153829 DMIBS95 DI DMIBS95 DMIBS95 DN SB-2280 DMIBS95 MI TTCJG29 DMIBS95 MN Serine/threonine-protein kinase mTOR (mTOR) DMIBS95 MT DTT DMIBS95 MA Inhibitor DMIBS95 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2109). DMIBS95 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2109 DMYQDPM DI DMYQDPM DMYQDPM DN SB236057 DMYQDPM MI TTK8CXU DMYQDPM MN 5-HT 1B receptor (HTR1B) DMYQDPM MT DTT DMYQDPM MA Antagonist DMYQDPM RN SB-236057, a selective 5-HT1B receptor inverse agonist, blocks the 5-HT human terminal autoreceptor. Eur J Pharmacol. 1999 Jun 30;375(1-3):359-65. DMYQDPM RU https://pubmed.ncbi.nlm.nih.gov/10443589 DMLZDK6 DI DMLZDK6 DMLZDK6 DN SB251023 DMLZDK6 MI TTMXGCW DMLZDK6 MN Adrenergic receptor beta-3 (ADRB3) DMLZDK6 MT DTT DMLZDK6 MA Agonist DMLZDK6 RN Mouse beta 3a- and beta 3b-adrenoceptors expressed in Chinese hamster ovary cells display identical pharmacology but utilize distinct signalling pathways. Br J Pharmacol. 2002 Apr;135(8):1903-14. DMLZDK6 RU https://pubmed.ncbi.nlm.nih.gov/11959793 DMO01AG DI DMO01AG DMO01AG DN SB-258719 DMO01AG MI TTO9X1H DMO01AG MN 5-HT 7 receptor (HTR7) DMO01AG MT DTT DMO01AG MA Inhibitor DMO01AG RN Higher-end serotonin receptors: 5-HT(5), 5-HT(6), and 5-HT(7). J Med Chem. 2003 Jul 3;46(14):2795-812. DMO01AG RU https://pubmed.ncbi.nlm.nih.gov/12825922 DMO01AG DI DMO01AG DMO01AG DN SB-258719 DMO01AG MI TTEX248 DMO01AG MN Dopamine D2 receptor (D2R) DMO01AG MT DTT DMO01AG MA Inhibitor DMO01AG RN Atropisomeric derivatives of 2',6'-disubstituted (R)-11-phenylaporphine: selective serotonin 5-HT(7) receptor antagonists. J Med Chem. 2001 Apr 26;44(9):1337-40. DMO01AG RU https://pubmed.ncbi.nlm.nih.gov/11311055 DM0HK6L DI DM0HK6L DM0HK6L DN SB-258741 DM0HK6L MI TTO9X1H DM0HK6L MN 5-HT 7 receptor (HTR7) DM0HK6L MT DTT DM0HK6L MA Inhibitor DM0HK6L RN Higher-end serotonin receptors: 5-HT(5), 5-HT(6), and 5-HT(7). J Med Chem. 2003 Jul 3;46(14):2795-812. DM0HK6L RU https://pubmed.ncbi.nlm.nih.gov/12825922 DM8UKH7 DI DM8UKH7 DM8UKH7 DN SB-265123 DM8UKH7 MI TTT1R2L DM8UKH7 MN Integrin alpha-V (ITGAV) DM8UKH7 MT DTT DM8UKH7 MA Inhibitor DM8UKH7 RN 1,2,3,4-Tetrahydroquinoline-containing alphaVbeta3 integrin antagonists with enhanced oral bioavailability. Bioorg Med Chem Lett. 2004 Dec 6;14(23):5937-41. DM8UKH7 RU https://pubmed.ncbi.nlm.nih.gov/15501072 DM8UKH7 DI DM8UKH7 DM8UKH7 DN SB-265123 DM8UKH7 MI TTBVIQC DM8UKH7 MN Integrin beta-1 (ITGB1) DM8UKH7 MT DTT DM8UKH7 MA Inhibitor DM8UKH7 RN Orally bioavailable nonpeptide vitronectin receptor antagonists with efficacy in an osteoporosis model. Bioorg Med Chem Lett. 1999 Jul 5;9(13):1807-12. DM8UKH7 RU https://pubmed.ncbi.nlm.nih.gov/10406646 DM8UKH7 DI DM8UKH7 DM8UKH7 DN SB-265123 DM8UKH7 MI TTJA1ZO DM8UKH7 MN ITGB3 messenger RNA (ITGB3 mRNA) DM8UKH7 MT DTT DM8UKH7 MA Inhibitor DM8UKH7 RN 1,2,3,4-Tetrahydroquinoline-containing alphaVbeta3 integrin antagonists with enhanced oral bioavailability. Bioorg Med Chem Lett. 2004 Dec 6;14(23):5937-41. DM8UKH7 RU https://pubmed.ncbi.nlm.nih.gov/15501072 DMEGNJK DI DMEGNJK DMEGNJK DN SB269652 DMEGNJK MI TTEX248 DMEGNJK MN Dopamine D2 receptor (D2R) DMEGNJK MT DTT DMEGNJK MA Modulator (allosteric modulator) DMEGNJK RN A new mechanism of allostery in a G protein-coupled receptor dimer. Nat Chem Biol. 2014 Sep;10(9):745-52. DMEGNJK RU https://pubmed.ncbi.nlm.nih.gov/25108820 DMEGNJK DI DMEGNJK DMEGNJK DN SB269652 DMEGNJK MI TT4C8EA DMEGNJK MN Dopamine D3 receptor (D3R) DMEGNJK MT DTT DMEGNJK MA Modulator (allosteric modulator) DMEGNJK RN Investigation of the binding and functional properties of extended length D3 dopamine receptor-selective antagonists. Eur Neuropsychopharmacol. 2015 Sep;25(9):1448-61. DMEGNJK RU https://pubmed.ncbi.nlm.nih.gov/25583363 DM5VJAF DI DM5VJAF DM5VJAF DN SB-271046 DM5VJAF MI TTSQIFT DM5VJAF MN 5-HT 1A receptor (HTR1A) DM5VJAF MT DTT DM5VJAF MA Inhibitor DM5VJAF RN Discovery of 3-aryl-3-methyl-1H-quinoline-2,4-diones as a new class of selective 5-HT6 receptor antagonists. Bioorg Med Chem Lett. 2008 Jan 15;18(2):738-43. DM5VJAF RU https://pubmed.ncbi.nlm.nih.gov/18053713 DM5VJAF DI DM5VJAF DM5VJAF DN SB-271046 DM5VJAF MI TTJQOD7 DM5VJAF MN 5-HT 2A receptor (HTR2A) DM5VJAF MT DTT DM5VJAF MA Inhibitor DM5VJAF RN Discovery of 3-aryl-3-methyl-1H-quinoline-2,4-diones as a new class of selective 5-HT6 receptor antagonists. Bioorg Med Chem Lett. 2008 Jan 15;18(2):738-43. DM5VJAF RU https://pubmed.ncbi.nlm.nih.gov/18053713 DM5VJAF DI DM5VJAF DM5VJAF DN SB-271046 DM5VJAF MI TTWJBZ5 DM5VJAF MN 5-HT 2C receptor (HTR2C) DM5VJAF MT DTT DM5VJAF MA Inhibitor DM5VJAF RN Discovery of 3-aryl-3-methyl-1H-quinoline-2,4-diones as a new class of selective 5-HT6 receptor antagonists. Bioorg Med Chem Lett. 2008 Jan 15;18(2):738-43. DM5VJAF RU https://pubmed.ncbi.nlm.nih.gov/18053713 DM5VJAF DI DM5VJAF DM5VJAF DN SB-271046 DM5VJAF MI TTJS8PY DM5VJAF MN 5-HT 6 receptor (HTR6) DM5VJAF MT DTT DM5VJAF MA Inhibitor DM5VJAF RN Synthesis and SAR of tolylamine 5-HT6 antagonists. Bioorg Med Chem Lett. 2009 May 1;19(9):2409-12. DM5VJAF RU https://pubmed.ncbi.nlm.nih.gov/19346128 DM5VJAF DI DM5VJAF DM5VJAF DN SB-271046 DM5VJAF MI TTO9X1H DM5VJAF MN 5-HT 7 receptor (HTR7) DM5VJAF MT DTT DM5VJAF MA Inhibitor DM5VJAF RN Discovery of 3-aryl-3-methyl-1H-quinoline-2,4-diones as a new class of selective 5-HT6 receptor antagonists. Bioorg Med Chem Lett. 2008 Jan 15;18(2):738-43. DM5VJAF RU https://pubmed.ncbi.nlm.nih.gov/18053713 DM5VJAF DI DM5VJAF DM5VJAF DN SB-271046 DM5VJAF MI TTZFYLI DM5VJAF MN Dopamine D1 receptor (D1R) DM5VJAF MT DTT DM5VJAF MA Inhibitor DM5VJAF RN Discovery of 3-aryl-3-methyl-1H-quinoline-2,4-diones as a new class of selective 5-HT6 receptor antagonists. Bioorg Med Chem Lett. 2008 Jan 15;18(2):738-43. DM5VJAF RU https://pubmed.ncbi.nlm.nih.gov/18053713 DM5VJAF DI DM5VJAF DM5VJAF DN SB-271046 DM5VJAF MI TTEX248 DM5VJAF MN Dopamine D2 receptor (D2R) DM5VJAF MT DTT DM5VJAF MA Inhibitor DM5VJAF RN Discovery of 3-aryl-3-methyl-1H-quinoline-2,4-diones as a new class of selective 5-HT6 receptor antagonists. Bioorg Med Chem Lett. 2008 Jan 15;18(2):738-43. DM5VJAF RU https://pubmed.ncbi.nlm.nih.gov/18053713 DM5VJAF DI DM5VJAF DM5VJAF DN SB-271046 DM5VJAF MI TT4C8EA DM5VJAF MN Dopamine D3 receptor (D3R) DM5VJAF MT DTT DM5VJAF MA Inhibitor DM5VJAF RN Discovery of 3-aryl-3-methyl-1H-quinoline-2,4-diones as a new class of selective 5-HT6 receptor antagonists. Bioorg Med Chem Lett. 2008 Jan 15;18(2):738-43. DM5VJAF RU https://pubmed.ncbi.nlm.nih.gov/18053713 DM5VJAF DI DM5VJAF DM5VJAF DN SB-271046 DM5VJAF MI TTE0A2F DM5VJAF MN Dopamine D4 receptor (D4R) DM5VJAF MT DTT DM5VJAF MA Inhibitor DM5VJAF RN Discovery of 3-aryl-3-methyl-1H-quinoline-2,4-diones as a new class of selective 5-HT6 receptor antagonists. Bioorg Med Chem Lett. 2008 Jan 15;18(2):738-43. DM5VJAF RU https://pubmed.ncbi.nlm.nih.gov/18053713 DM28K0E DI DM28K0E DM28K0E DN SB290157 DM28K0E MI TTI6B3F DM28K0E MN C3a anaphylatoxin chemotactic receptor (C3AR1) DM28K0E MT DTT DM28K0E MA Antagonist DM28K0E RN Identification of a selective nonpeptide antagonist of the anaphylatoxin C3a receptor that demonstrates antiinflammatory activity in animal models. J Immunol. 2001 May 15;166(10):6341-8. DM28K0E RU https://pubmed.ncbi.nlm.nih.gov/11342658 DMU2J3K DI DMU2J3K DMU2J3K DN SB-298 DMU2J3K MI TTK25J1 DMU2J3K MN Adenosine A1 receptor (ADORA1) DMU2J3K MT DTT DMU2J3K MA Inhibitor DMU2J3K RN 1-alkyl-8-(piperazine-1-sulfonyl)phenylxanthines: development and characterization of adenosine A2B receptor antagonists and a new radioligand with... J Med Chem. 2009 Jul 9;52(13):3994-4006. DMU2J3K RU https://pubmed.ncbi.nlm.nih.gov/19569717 DMU2J3K DI DMU2J3K DMU2J3K DN SB-298 DMU2J3K MI TTM2AOE DMU2J3K MN Adenosine A2a receptor (ADORA2A) DMU2J3K MT DTT DMU2J3K MA Inhibitor DMU2J3K RN 1-alkyl-8-(piperazine-1-sulfonyl)phenylxanthines: development and characterization of adenosine A2B receptor antagonists and a new radioligand with... J Med Chem. 2009 Jul 9;52(13):3994-4006. DMU2J3K RU https://pubmed.ncbi.nlm.nih.gov/19569717 DMU2J3K DI DMU2J3K DMU2J3K DN SB-298 DMU2J3K MI TTNE7KG DMU2J3K MN Adenosine A2b receptor (ADORA2B) DMU2J3K MT DTT DMU2J3K MA Inhibitor DMU2J3K RN 1-alkyl-8-(piperazine-1-sulfonyl)phenylxanthines: development and characterization of adenosine A2B receptor antagonists and a new radioligand with... J Med Chem. 2009 Jul 9;52(13):3994-4006. DMU2J3K RU https://pubmed.ncbi.nlm.nih.gov/19569717 DMU2J3K DI DMU2J3K DMU2J3K DN SB-298 DMU2J3K MI TTJFY5U DMU2J3K MN Adenosine A3 receptor (ADORA3) DMU2J3K MT DTT DMU2J3K MA Inhibitor DMU2J3K RN 1-alkyl-8-(piperazine-1-sulfonyl)phenylxanthines: development and characterization of adenosine A2B receptor antagonists and a new radioligand with... J Med Chem. 2009 Jul 9;52(13):3994-4006. DMU2J3K RU https://pubmed.ncbi.nlm.nih.gov/19569717 DMT1KFL DI DMT1KFL DMT1KFL DN SB-328872 DMT1KFL MI TTW5UDX DMT1KFL MN Urotensin II receptor (UTS2R) DMT1KFL MT DTT DMT1KFL MA Inhibitor DMT1KFL RN Urotensin-II receptor antagonists: synthesis and SAR of N-cyclic azaalkyl benzamides. Bioorg Med Chem Lett. 2008 Jul 15;18(14):3950-4. DMT1KFL RU https://pubmed.ncbi.nlm.nih.gov/18573659 DMDZKWJ DI DMDZKWJ DMDZKWJ DN SB-334867 DMDZKWJ MI TT60Q8D DMDZKWJ MN Orexin receptor type 1 (HCRTR1) DMDZKWJ MT DTT DMDZKWJ MA Antagonist DMDZKWJ RN Biochemical and electrophysiological characterization of almorexant, a dual orexin 1 receptor (OX1)/orexin 2 receptor (OX2) antagonist: comparison ... Mol Pharmacol. 2009 Sep;76(3):618-31. DMDZKWJ RU https://pubmed.ncbi.nlm.nih.gov/19542319 DMDZKWJ DI DMDZKWJ DMDZKWJ DN SB-334867 DMDZKWJ MI TT9N02I DMDZKWJ MN Orexin receptor type 2 (HCRTR2) DMDZKWJ MT DTT DMDZKWJ MA Antagonist DMDZKWJ RN Biochemical and electrophysiological characterization of almorexant, a dual orexin 1 receptor (OX1)/orexin 2 receptor (OX2) antagonist: comparison ... Mol Pharmacol. 2009 Sep;76(3):618-31. DMDZKWJ RU https://pubmed.ncbi.nlm.nih.gov/19542319 DMFTO8R DI DMFTO8R DMFTO8R DN SB-357134 DMFTO8R MI TTJS8PY DMFTO8R MN 5-HT 6 receptor (HTR6) DMFTO8R MT DTT DMFTO8R MA Inhibitor DMFTO8R RN Discovery of 3-aryl-3-methyl-1H-quinoline-2,4-diones as a new class of selective 5-HT6 receptor antagonists. Bioorg Med Chem Lett. 2008 Jan 15;18(2):738-43. DMFTO8R RU https://pubmed.ncbi.nlm.nih.gov/18053713 DM3BV5S DI DM3BV5S DM3BV5S DN SB-381320 DM3BV5S MI TTDNFMT DM3BV5S MN Platelet-activating factor acetylhydrolase (PLA2G7) DM3BV5S MT DTT DM3BV5S MA Inhibitor DM3BV5S RN (E)-Phenyl- and -heteroaryl-substituted O-benzoyl-(or acyl)oximes as lipoprotein-associated phospholipase A2 inhibitors. Bioorg Med Chem Lett. 2005 Mar 1;15(5):1525-7. DM3BV5S RU https://pubmed.ncbi.nlm.nih.gov/15713421 DMFMK89 DI DMFMK89 DMFMK89 DN SB399885 DMFMK89 MI TTJS8PY DMFMK89 MN 5-HT 6 receptor (HTR6) DMFMK89 MT DTT DMFMK89 MA Antagonist DMFMK89 RN SB-399885 is a potent, selective 5-HT6 receptor antagonist with cognitive enhancing properties in aged rat water maze and novel object recognition ... Eur J Pharmacol. 2006 Dec 28;553(1-3):109-19. DMFMK89 RU https://pubmed.ncbi.nlm.nih.gov/17069795 DMB8XZP DI DMB8XZP DMB8XZP DN SB-408124 DMB8XZP MI TT60Q8D DMB8XZP MN Orexin receptor type 1 (HCRTR1) DMB8XZP MT DTT DMB8XZP MA Antagonist DMB8XZP RN Biochemical and electrophysiological characterization of almorexant, a dual orexin 1 receptor (OX1)/orexin 2 receptor (OX2) antagonist: comparison ... Mol Pharmacol. 2009 Sep;76(3):618-31. DMB8XZP RU https://pubmed.ncbi.nlm.nih.gov/19542319 DMB8XZP DI DMB8XZP DMB8XZP DN SB-408124 DMB8XZP MI TT9N02I DMB8XZP MN Orexin receptor type 2 (HCRTR2) DMB8XZP MT DTT DMB8XZP MA Antagonist DMB8XZP RN Biochemical and electrophysiological characterization of almorexant, a dual orexin 1 receptor (OX1)/orexin 2 receptor (OX2) antagonist: comparison ... Mol Pharmacol. 2009 Sep;76(3):618-31. DMB8XZP RU https://pubmed.ncbi.nlm.nih.gov/19542319 DMQLHE8 DI DMQLHE8 DMQLHE8 DN SB-410220 DMQLHE8 MI TT60Q8D DMQLHE8 MN Orexin receptor type 1 (HCRTR1) DMQLHE8 MT DTT DMQLHE8 MA Antagonist DMQLHE8 RN Characterisation of the binding of [3H]-SB-674042, a novel nonpeptide antagonist, to the human orexin-1 receptor. Br J Pharmacol. 2004 Jan;141(2):340-6. DMQLHE8 RU https://pubmed.ncbi.nlm.nih.gov/14691055 DMMAL3I DI DMMAL3I DMMAL3I DN SB-415286 DMMAL3I MI TTRSMW9 DMMAL3I MN Glycogen synthase kinase-3 beta (GSK-3B) DMMAL3I MT DTT DMMAL3I MA Inhibitor DMMAL3I RN Fragment and knowledge-based design of selective GSK-3beta inhibitors using virtual screening models. Eur J Med Chem. 2009 Jun;44(6):2361-71. DMMAL3I RU https://pubmed.ncbi.nlm.nih.gov/18929433 DMMAL3I DI DMMAL3I DMMAL3I DN SB-415286 DMMAL3I MI TTG0U4H DMMAL3I MN Ribosomal protein S6 kinase beta-1 (S6K1) DMMAL3I MT DTT DMMAL3I MA Inhibitor DMMAL3I RN 3-Anilino-4-arylmaleimides: potent and selective inhibitors of glycogen synthase kinase-3 (GSK-3). Bioorg Med Chem Lett. 2001 Mar 12;11(5):635-9. DMMAL3I RU https://pubmed.ncbi.nlm.nih.gov/11266159 DMJW72O DI DMJW72O DMJW72O DN SB-416 DMJW72O MI TTOZHQC DMJW72O MN P2Y purinoceptor 2 (P2RY2) DMJW72O MT DTT DMJW72O MA Inhibitor DMJW72O RN Combinatorial synthesis of anilinoanthraquinone derivatives and evaluation as non-nucleotide-derived P2Y2 receptor antagonists. Bioorg Med Chem Lett. 2008 Jan 1;18(1):223-7. DMJW72O RU https://pubmed.ncbi.nlm.nih.gov/18006312 DMUFV4O DI DMUFV4O DMUFV4O DN SB452533 DMUFV4O MI TTMI6F5 DMUFV4O MN Transient receptor potential cation channel V1 (TRPV1) DMUFV4O MT DTT DMUFV4O MA Blocker (channel blocker) DMUFV4O RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 507). DMUFV4O RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=507 DM4G09S DI DM4G09S DM4G09S DN SB-505124 DM4G09S MI TTP4520 DM4G09S MN TGF-beta receptor type I (TGFBR1) DM4G09S MT DTT DM4G09S MA Inhibitor DM4G09S RN Synthesis and biological evaluation of 2-pyridyl-substituted pyrazoles and imidazoles as transforming growth factor-beta type 1 receptor kinase inhibitors, Bioorg. Med. Chem. Lett. 20(14):4228-4232 (2010). DM4G09S RU http://www.sciencedirect.com/science/article/pii/S0960894X10006736 DM0PETL DI DM0PETL DM0PETL DN SB-525334 DM0PETL MI TTP4520 DM0PETL MN TGF-beta receptor type I (TGFBR1) DM0PETL MT DTT DM0PETL MA Inhibitor DM0PETL RN Synthesis and biological evaluation of 2-pyridyl-substituted pyrazoles and imidazoles as transforming growth factor-beta type 1 receptor kinase inhibitors, Bioorg. Med. Chem. Lett. 20(14):4228-4232 (2010). DM0PETL RU http://www.sciencedirect.com/science/article/pii/S0960894X10006736 DM0OLYF DI DM0OLYF DM0OLYF DN SB-559457 DM0OLYF MI TTIHYA4 DM0OLYF MN Thrombopoietin receptor (MPL) DM0OLYF MT DTT DM0OLYF MA Agonist DM0OLYF RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1722). DM0OLYF RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1722 DMBIF42 DI DMBIF42 DMBIF42 DN SB-568849 DMBIF42 MI TTX4RTB DMBIF42 MN Melanin-concentrating hormone receptor 1 (MCHR1) DMBIF42 MT DTT DMBIF42 MA Antagonist DMBIF42 RN Discovery of potent and stable conformationally constrained analogues of the MCH R1 antagonist SB-568849. Bioorg Med Chem Lett. 2006 Sep 15;16(18):4872-8. DMBIF42 RU https://pubmed.ncbi.nlm.nih.gov/16839763 DMASQV4 DI DMASQV4 DMASQV4 DN SB-611812 DMASQV4 MI TTW5UDX DMASQV4 MN Urotensin II receptor (UTS2R) DMASQV4 MT DTT DMASQV4 MA Antagonist DMASQV4 RN A role for urotensin II in restenosis following balloon angioplasty: use of a selective UT receptor blocker. J Mol Cell Cardiol. 2005 Nov;39(5):785-91. DMASQV4 RU https://pubmed.ncbi.nlm.nih.gov/16171813 DM2SZ3F DI DM2SZ3F DM2SZ3F DN SB-612111 DM2SZ3F MI TTNT7K8 DM2SZ3F MN Nociceptin receptor (OPRL1) DM2SZ3F MT DTT DM2SZ3F MA Antagonist DM2SZ3F RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 320). DM2SZ3F RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=320 DMVOIL5 DI DMVOIL5 DMVOIL5 DN SB-656104 DMVOIL5 MI TTSQIFT DMVOIL5 MN 5-HT 1A receptor (HTR1A) DMVOIL5 MT DTT DMVOIL5 MA Inhibitor DMVOIL5 RN Novel 3-aminochromans as potential pharmacological tools for the serotonin 5-HT(7) receptor. Bioorg Med Chem Lett. 2005 Feb 1;15(3):747-50. DMVOIL5 RU https://pubmed.ncbi.nlm.nih.gov/15664850 DMVOIL5 DI DMVOIL5 DMVOIL5 DN SB-656104 DMVOIL5 MI TTO9X1H DMVOIL5 MN 5-HT 7 receptor (HTR7) DMVOIL5 MT DTT DMVOIL5 MA Inhibitor DMVOIL5 RN Higher-end serotonin receptors: 5-HT(5), 5-HT(6), and 5-HT(7). J Med Chem. 2003 Jul 3;46(14):2795-812. DMVOIL5 RU https://pubmed.ncbi.nlm.nih.gov/12825922 DMLW8BI DI DMLW8BI DMLW8BI DN SB-699551-A DMLW8BI MI TTRUFDT DMLW8BI MN 5-HT 5A receptor (HTR5A) DMLW8BI MT DTT DMLW8BI MA Antagonist DMLW8BI RN 5-ht5A receptors as a therapeutic target. Pharmacol Ther. 2006 Sep;111(3):707-14. DMLW8BI RU https://pubmed.ncbi.nlm.nih.gov/16516972 DM9ZYNJ DI DM9ZYNJ DM9ZYNJ DN SB-706375 DM9ZYNJ MI TTW5UDX DM9ZYNJ MN Urotensin II receptor (UTS2R) DM9ZYNJ MT DTT DM9ZYNJ MA Inhibitor DM9ZYNJ RN Urotensin-II receptor modulators as potential drugs. J Med Chem. 2010 Apr 8;53(7):2695-708. DM9ZYNJ RU https://pubmed.ncbi.nlm.nih.gov/20043680 DMO2EXW DI DMO2EXW DMO2EXW DN SB-731489 DMO2EXW MI TTBGTCW DMO2EXW MN Kinesin spindle messenger RNA (KIF11 mRNA) DMO2EXW MT DTT DMO2EXW MA Inhibitor DMO2EXW RN Novel ATP-competitive kinesin spindle protein inhibitors. J Med Chem. 2007 Oct 4;50(20):4939-52. DMO2EXW RU https://pubmed.ncbi.nlm.nih.gov/17725339 DM20Q5O DI DM20Q5O DM20Q5O DN SB-747651A DM20Q5O MI TTO6SGY DM20Q5O MN AKT3 messenger RNA (AKT3 mRNA) DM20Q5O MT DTT DM20Q5O MA Inhibitor DM20Q5O RN Identification of 4-(2-(4-amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-{[(3S)-3-piperidinylmethyl]oxy}-1H-imidazo[4,5-c]pyridin-4-yl)-2-methyl-3-butyn-2-o... J Med Chem. 2008 Sep 25;51(18):5663-79. DM20Q5O RU https://pubmed.ncbi.nlm.nih.gov/18800763 DM20Q5O DI DM20Q5O DM20Q5O DN SB-747651A DM20Q5O MI TTWTSCV DM20Q5O MN RAC-alpha serine/threonine-protein kinase (AKT1) DM20Q5O MT DTT DM20Q5O MA Inhibitor DM20Q5O RN Identification of 4-(2-(4-amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-{[(3S)-3-piperidinylmethyl]oxy}-1H-imidazo[4,5-c]pyridin-4-yl)-2-methyl-3-butyn-2-o... J Med Chem. 2008 Sep 25;51(18):5663-79. DM20Q5O RU https://pubmed.ncbi.nlm.nih.gov/18800763 DM20Q5O DI DM20Q5O DM20Q5O DN SB-747651A DM20Q5O MI TTZN7RP DM20Q5O MN Rho-associated protein kinase 1 (ROCK1) DM20Q5O MT DTT DM20Q5O MA Inhibitor DM20Q5O RN Identification of 4-(2-(4-amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-{[(3S)-3-piperidinylmethyl]oxy}-1H-imidazo[4,5-c]pyridin-4-yl)-2-methyl-3-butyn-2-o... J Med Chem. 2008 Sep 25;51(18):5663-79. DM20Q5O RU https://pubmed.ncbi.nlm.nih.gov/18800763 DM20Q5O DI DM20Q5O DM20Q5O DN SB-747651A DM20Q5O MI TTG0U4H DM20Q5O MN Ribosomal protein S6 kinase beta-1 (S6K1) DM20Q5O MT DTT DM20Q5O MA Inhibitor DM20Q5O RN (1H-imidazo[4,5-c]pyridin-2-yl)-1,2,5-oxadiazol-3-ylamine derivatives: further optimisation as highly potent and selective MSK-1-inhibitors. Bioorg Med Chem Lett. 2005 Jul 15;15(14):3407-11. DM20Q5O RU https://pubmed.ncbi.nlm.nih.gov/15955699 DMYL56F DI DMYL56F DMYL56F DN SB-782443 DMYL56F MI TTMI6F5 DMYL56F MN Transient receptor potential cation channel V1 (TRPV1) DMYL56F MT DTT DMYL56F MA Inhibitor DMYL56F RN Design and synthesis of 6-phenylnicotinamide derivatives as antagonists of TRPV1. Bioorg Med Chem Lett. 2008 Oct 15;18(20):5609-13. DMYL56F RU https://pubmed.ncbi.nlm.nih.gov/18809327 DMU8KGB DI DMU8KGB DMU8KGB DN SBB007833 DMU8KGB MI TT6PKBN DMU8KGB MN Proto-oncogene c-Src (SRC) DMU8KGB MT DTT DMU8KGB MA Inhibitor DMU8KGB RN Synthesis and pharmacological evaluation of novel beta-nitrostyrene derivatives as tyrosine kinase inhibitors with potent antiplatelet activity. Biochem Pharmacol. 2007 Aug 15;74(4):601-11. DMU8KGB RU https://pubmed.ncbi.nlm.nih.gov/17601492 DMU8KGB DI DMU8KGB DMU8KGB DN SBB007833 DMU8KGB MI TTOU65C DMU8KGB MN Tyrosine-protein kinase SYK (SYK) DMU8KGB MT DTT DMU8KGB MA Inhibitor DMU8KGB RN Synthesis and pharmacological evaluation of novel beta-nitrostyrene derivatives as tyrosine kinase inhibitors with potent antiplatelet activity. Biochem Pharmacol. 2007 Aug 15;74(4):601-11. DMU8KGB RU https://pubmed.ncbi.nlm.nih.gov/17601492 DMCRQ29 DI DMCRQ29 DMCRQ29 DN S-benzo[d]oxazol-2-yl O-butyl carbonothioate DMCRQ29 MI TT6804T DMCRQ29 MN MIF messenger RNA (MIF mRNA) DMCRQ29 MT DTT DMCRQ29 MA Inhibitor DMCRQ29 RN An integrative in silico methodology for the identification of modulators of macrophage migration inhibitory factor (MIF) tautomerase activity. Bioorg Med Chem. 2010 Jul 15;18(14):5425-40. DMCRQ29 RU https://pubmed.ncbi.nlm.nih.gov/20639113 DMDUC2X DI DMDUC2X DMDUC2X DN S-benzyl phenylmethanesulfinothioate DMDUC2X MI TT2SUAQ DMDUC2X MN Cysteine protease (CYP) DMDUC2X MT DTT DMDUC2X MA Inhibitor DMDUC2X RN Allicin and derivates are cysteine protease inhibitors with antiparasitic activity. Bioorg Med Chem Lett. 2010 Sep 15;20(18):5541-3. DMDUC2X RU https://pubmed.ncbi.nlm.nih.gov/20692829 DM2RLXF DI DM2RLXF DM2RLXF DN S-Benzyl-brassinin DM2RLXF MI TTZJYKH DM2RLXF MN Indoleamine 2,3-dioxygenase 1 (IDO1) DM2RLXF MT DTT DM2RLXF MA Inhibitor DM2RLXF RN Structure-activity study of brassinin derivatives as indoleamine 2,3-dioxygenase inhibitors. J Med Chem. 2006 Jan 26;49(2):684-92. DM2RLXF RU https://pubmed.ncbi.nlm.nih.gov/16420054 DMIQU8D DI DMIQU8D DMIQU8D DN S-Benzyl-Glutathione DMIQU8D MI TTV9A7R DMIQU8D MN Lactoylglutathione lyase (GLO1) DMIQU8D MT DTT DMIQU8D MA Inhibitor DMIQU8D RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMIQU8D RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMDBLGQ DI DMDBLGQ DMDBLGQ DN SBTI DMDBLGQ MI TT5T3P6 DMDBLGQ MN Tissue kallikrein (KLK1) DMDBLGQ MT DTT DMDBLGQ MA Inhibitor DMDBLGQ RN Expression and characterization of human tissue kallikrein variants. Protein Expr Purif. 1998 Apr;12(3):361-70. DMDBLGQ RU https://pubmed.ncbi.nlm.nih.gov/9535704 DMD2WEQ DI DMD2WEQ DMD2WEQ DN SC-0030 DMD2WEQ MI TTMI6F5 DMD2WEQ MN Transient receptor potential cation channel V1 (TRPV1) DMD2WEQ MT DTT DMD2WEQ MA Inhibitor DMD2WEQ RN Silicon switch approach in TRPV1 antagonist MK-056 and its analogues. Bioorg Med Chem. 2010 Jan 1;18(1):111-6. DMD2WEQ RU https://pubmed.ncbi.nlm.nih.gov/19931463 DMD2WEQ DI DMD2WEQ DMD2WEQ DN SC-0030 DMD2WEQ MI TTKP2SU DMD2WEQ MN Transient receptor potential cation channel V4 (TRPV4) DMD2WEQ MT DTT DMD2WEQ MA Inhibitor DMD2WEQ RN Novel non-vanilloid VR1 antagonist of high analgesic effects and its structural requirement for VR1 antagonistic effects. Bioorg Med Chem Lett. 2003 Dec 15;13(24):4389-93. DMD2WEQ RU https://pubmed.ncbi.nlm.nih.gov/14643332 DMU2C9W DI DMU2C9W DMU2C9W DN SC-19220 DMU2C9W MI TTG1QMU DMU2C9W MN Prostaglandin E2 receptor EP1 (PTGER1) DMU2C9W MT DTT DMU2C9W MA Antagonist DMU2C9W RN Molecular cloning and characterization of the four rat prostaglandin E2 prostanoid receptor subtypes. Eur J Pharmacol. 1997 Dec 11;340(2-3):227-41. DMU2C9W RU https://pubmed.ncbi.nlm.nih.gov/9537820 DMCWZ84 DI DMCWZ84 DMCWZ84 DN SC-41661A DMCWZ84 MI TT2J34L DMCWZ84 MN Arachidonate 5-lipoxygenase (5-LOX) DMCWZ84 MT DTT DMCWZ84 MA Modulator DMCWZ84 RN Induction of apoptosis in blood cells from a patient with acute myelogenous leukemia by SC41661A, a selective inhibitor of 5-lipoxygenase. Prostaglandins Leukot Essent Fatty Acids. 1993 Apr;48(4):323-6. DMCWZ84 RU https://www.ncbi.nlm.nih.gov/pubmed/8497493 DMVZ9Q0 DI DMVZ9Q0 DMVZ9Q0 DN Sc-43076 DMVZ9Q0 MI TTSJIRP DMVZ9Q0 MN Connexin 32 messenger RNA (GJB1 mRNA) DMVZ9Q0 MT DTT DMVZ9Q0 RN Connexin Antibodies. Report from santa cruz biotechnology, inc. Santa cruz biotechnology. 2009. DMVZ9Q0 RU http://www.scbt.com/table-connexin.html DMYDS5Z DI DMYDS5Z DMYDS5Z DN Sc-43077 DMYDS5Z MI TTSJIRP DMYDS5Z MN Connexin 32 messenger RNA (GJB1 mRNA) DMYDS5Z MT DTT DMYDS5Z RN Connexin Antibodies. Report from santa cruz biotechnology, inc. Santa cruz biotechnology. 2009. DMYDS5Z RU http://www.scbt.com/table-connexin.html DM6AS0P DI DM6AS0P DM6AS0P DN SC46275 DM6AS0P MI TTPNGDE DM6AS0P MN Prostaglandin E2 receptor EP3 (PTGER3) DM6AS0P MT DTT DM6AS0P MA Agonist DM6AS0P RN Investigation of the pronounced synergism between prostaglandin E2 and other constrictor agents on rat femoral artery. Prostaglandins Leukot Essent Fatty Acids. 2006 Jun;74(6):401-15. DM6AS0P RU https://pubmed.ncbi.nlm.nih.gov/16737803 DM2DU80 DI DM2DU80 DM2DU80 DN SC-5003 DM2DU80 MI TTH9VL3 DM2DU80 MN Plasmodium Plasmepsin 1 (Malaria PLA1) DM2DU80 MT DTT DM2DU80 MA Inhibitor DM2DU80 RN Protease inhibitors: current status and future prospects. J Med Chem. 2000 Feb 10;43(3):305-41. DM2DU80 RU https://pubmed.ncbi.nlm.nih.gov/10669559 DMU2WIS DI DMU2WIS DMU2WIS DN SC-50073 DMU2WIS MI TTN53ZF DMU2WIS MN Leukotriene B4 receptor 1 (LTB4R) DMU2WIS MT DTT DMU2WIS MA Inhibitor DMU2WIS RN Synthesis and pharmacological activity of SC-53228, a leukotriene B4 receptor antagonist with high intrinsic potency and selectivity, Bioorg. Med. Chem. Lett. 4(6):811-816 (1994). DMU2WIS RU http://www.sciencedirect.com/science/article/pii/S0960894X01808532 DMI2KE7 DI DMI2KE7 DMI2KE7 DN SC-50135 DMI2KE7 MI TTN53ZF DMI2KE7 MN Leukotriene B4 receptor 1 (LTB4R) DMI2KE7 MT DTT DMI2KE7 MA Inhibitor DMI2KE7 RN Synthesis and pharmacological activity of SC-53228, a leukotriene B4 receptor antagonist with high intrinsic potency and selectivity, Bioorg. Med. Chem. Lett. 4(6):811-816 (1994). DMI2KE7 RU http://www.sciencedirect.com/science/article/pii/S0960894X01808532 DM8RJ0V DI DM8RJ0V DM8RJ0V DN SC-50676 DM8RJ0V MI TTN53ZF DM8RJ0V MN Leukotriene B4 receptor 1 (LTB4R) DM8RJ0V MT DTT DM8RJ0V MA Inhibitor DM8RJ0V RN Synthesis and pharmacological activity of SC-53228, a leukotriene B4 receptor antagonist with high intrinsic potency and selectivity, Bioorg. Med. Chem. Lett. 4(6):811-816 (1994). DM8RJ0V RU http://www.sciencedirect.com/science/article/pii/S0960894X01808532 DMBQ16F DI DMBQ16F DMBQ16F DN SC-50998 DMBQ16F MI TTCG0AL DMBQ16F MN Cholecystokinin receptor type A (CCKAR) DMBQ16F MT DTT DMBQ16F MA Antagonist DMBQ16F RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 76). DMBQ16F RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=76 DM0LWUV DI DM0LWUV DM0LWUV DN SC-51322 DM0LWUV MI TTG1QMU DM0LWUV MN Prostaglandin E2 receptor EP1 (PTGER1) DM0LWUV MT DTT DM0LWUV MA Modulator DM0LWUV RN Antihypertensive effects of selective prostaglandin E2 receptor subtype 1 targeting. J Clin Invest. 2007 Sep;117(9):2496-505. DM0LWUV RU https://www.ncbi.nlm.nih.gov/pubmed/17710229 DMAWI4M DI DMAWI4M DMAWI4M DN SC-514 DMAWI4M MI TTJ3E9X DMAWI4M MN Inhibitor of nuclear factor kappa-B kinase beta (IKKB) DMAWI4M MT DTT DMAWI4M MA Inhibitor DMAWI4M RN The selectivity of protein kinase inhibitors: a further update. Biochem J. 2007 Dec 15;408(3):297-315. DMAWI4M RU https://pubmed.ncbi.nlm.nih.gov/17850214 DM0E2SM DI DM0E2SM DM0E2SM DN SC-52073 DM0E2SM MI TTN53ZF DM0E2SM MN Leukotriene B4 receptor 1 (LTB4R) DM0E2SM MT DTT DM0E2SM MA Inhibitor DM0E2SM RN Synthesis and pharmacological activity of SC-53228, a leukotriene B4 receptor antagonist with high intrinsic potency and selectivity, Bioorg. Med. Chem. Lett. 4(6):811-816 (1994). DM0E2SM RU http://www.sciencedirect.com/science/article/pii/S0960894X01808532 DMJ576C DI DMJ576C DMJ576C DN SC-52491 DMJ576C MI TTNXLKE DMJ576C MN 5-HT 3 receptor (5HT3R) DMJ576C MT DTT DMJ576C MA Modulator DMJ576C RN Azaadamantane benzamide 5-HT4 agonists: gastrointestinal prokinetic SC-54750. Bioorg Med Chem Lett. 2004 Nov 15;14(22):5509-12. DMJ576C RU https://www.ncbi.nlm.nih.gov/pubmed/15482914 DMJ576C DI DMJ576C DMJ576C DN SC-52491 DMJ576C MI TT07C3Y DMJ576C MN 5-HT 4 receptor (HTR4) DMJ576C MT DTT DMJ576C MA Modulator DMJ576C RN Azaadamantane benzamide 5-HT4 agonists: gastrointestinal prokinetic SC-54750. Bioorg Med Chem Lett. 2004 Nov 15;14(22):5509-12. DMJ576C RU https://www.ncbi.nlm.nih.gov/pubmed/15482914 DMLOJ42 DI DMLOJ42 DMLOJ42 DN SC-52569 DMLOJ42 MI TTN53ZF DMLOJ42 MN Leukotriene B4 receptor 1 (LTB4R) DMLOJ42 MT DTT DMLOJ42 MA Inhibitor DMLOJ42 RN Synthesis and pharmacological activity of SC-53228, a leukotriene B4 receptor antagonist with high intrinsic potency and selectivity, Bioorg. Med. Chem. Lett. 4(6):811-816 (1994). DMLOJ42 RU http://www.sciencedirect.com/science/article/pii/S0960894X01808532 DMXA6LU DI DMXA6LU DMXA6LU DN SC-52892 DMXA6LU MI TTQVOEI DMXA6LU MN Angiotensin II receptor type-2 (AGTR2) DMXA6LU MT DTT DMXA6LU MA Inhibitor DMXA6LU RN N1-sterically hindered 2H-imidazol-2-one angiotensin II receptor antagonists: The conversion of surmountable antagonists to insurmountable antagonists, Bioorg. Med. Chem. Lett. 3(6):1055-1060 (1993). DMXA6LU RU http://www.sciencedirect.com/science/article/pii/S0960894X00802863 DMYH12X DI DMYH12X DMYH12X DN SC-53229 DMYH12X MI TTN53ZF DMYH12X MN Leukotriene B4 receptor 1 (LTB4R) DMYH12X MT DTT DMYH12X MA Inhibitor DMYH12X RN Synthesis and pharmacological activity of SC-53228, a leukotriene B4 receptor antagonist with high intrinsic potency and selectivity, Bioorg. Med. Chem. Lett. 4(6):811-816 (1994). DMYH12X RU http://www.sciencedirect.com/science/article/pii/S0960894X01808532 DM3BEKV DI DM3BEKV DM3BEKV DN SC-54701A DM3BEKV MI TTJA1ZO DM3BEKV MN ITGB3 messenger RNA (ITGB3 mRNA) DM3BEKV MT DTT DM3BEKV MA Inhibitor DM3BEKV RN Use of conformationally restricted benzamidines as arginine surrogates in the design of platelet GPIIb-IIIa receptor antagonists. J Med Chem. 1997 Aug 29;40(18):2843-57. DM3BEKV RU https://pubmed.ncbi.nlm.nih.gov/9288166 DMEUTXG DI DMEUTXG DMEUTXG DN SC-54750 DMEUTXG MI TTNXLKE DMEUTXG MN 5-HT 3 receptor (5HT3R) DMEUTXG MT DTT DMEUTXG MA Modulator DMEUTXG RN Azaadamantane benzamide 5-HT4 agonists: gastrointestinal prokinetic SC-54750. Bioorg Med Chem Lett. 2004 Nov 15;14(22):5509-12. DMEUTXG RU https://www.ncbi.nlm.nih.gov/pubmed/15482914 DMEUTXG DI DMEUTXG DMEUTXG DN SC-54750 DMEUTXG MI TT07C3Y DMEUTXG MN 5-HT 4 receptor (HTR4) DMEUTXG MT DTT DMEUTXG MA Modulator DMEUTXG RN Azaadamantane benzamide 5-HT4 agonists: gastrointestinal prokinetic SC-54750. Bioorg Med Chem Lett. 2004 Nov 15;14(22):5509-12. DMEUTXG RU https://www.ncbi.nlm.nih.gov/pubmed/15482914 DMLJ8T7 DI DMLJ8T7 DMLJ8T7 DN SC-55634 DMLJ8T7 MI TTQVOEI DMLJ8T7 MN Angiotensin II receptor type-2 (AGTR2) DMLJ8T7 MT DTT DMLJ8T7 MA Inhibitor DMLJ8T7 RN N1-sterically hindered 2H-imidazol-2-one angiotensin II receptor antagonists: The conversion of surmountable antagonists to insurmountable antagonists, Bioorg. Med. Chem. Lett. 3(6):1055-1060 (1993). DMLJ8T7 RU http://www.sciencedirect.com/science/article/pii/S0960894X00802863 DMAZLKX DI DMAZLKX DMAZLKX DN SC-558 DMAZLKX MI TTVKILB DMAZLKX MN Prostaglandin G/H synthase 2 (COX-2) DMAZLKX MT DTT DMAZLKX MA Inhibitor DMAZLKX RN In silico search for multi-target anti-inflammatories in Chinese herbs and formulas. Bioorg Med Chem. 2010 Mar 15;18(6):2204-2218. DMAZLKX RU https://pubmed.ncbi.nlm.nih.gov/20188577 DMT1GJL DI DMT1GJL DMT1GJL DN SC-560 DMT1GJL MI TT8NGED DMT1GJL MN Prostaglandin G/H synthase 1 (COX-1) DMT1GJL MT DTT DMT1GJL MA Inhibitor DMT1GJL RN Synthesis and antiinflammatory activity of coumarin derivatives. J Med Chem. 2005 Oct 6;48(20):6400-8. DMT1GJL RU https://pubmed.ncbi.nlm.nih.gov/16190766 DMZJQ1D DI DMZJQ1D DMZJQ1D DN SC-58272 DMZJQ1D MI TTBAF05 DMZJQ1D MN Candida Peptide N-myristoyltransferase (Candi NMT1) DMZJQ1D MT DTT DMZJQ1D MA Inhibitor DMZJQ1D RN Crystal structures of Saccharomyces cerevisiae N-myristoyltransferase with bound myristoyl-CoA and inhibitors reveal the functional roles of the N-... J Biol Chem. 2007 Jul 27;282(30):22185-94. DMZJQ1D RU https://pubmed.ncbi.nlm.nih.gov/17513302 DMNI91Z DI DMNI91Z DMNI91Z DN SC-74020 DMNI91Z MI TTLM12X DMNI91Z MN Matrix metalloproteinase-2 (MMP-2) DMNI91Z MT DTT DMNI91Z MA Inhibitor DMNI91Z RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMNI91Z RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMD71VB DI DMD71VB DMD71VB DN SC-79407 DMD71VB MI TT6L509 DMD71VB MN Coagulation factor IIa (F2) DMD71VB MT DTT DMD71VB MA Inhibitor DMD71VB RN Pharmacological intervention at disparate sites in the coagulation cascade: comparison of anti-thrombotic efficacy vs bleeding propensity in a rat model of acute arterial thrombosis. J Thromb Thrombolysis. 2002 Oct;14(2):113-21. DMD71VB RU https://pubmed.ncbi.nlm.nih.gov/12714830 DMZN7YT DI DMZN7YT DMZN7YT DN SC-795 DMZN7YT MI TTFQAYR DMZN7YT MN Cholesteryl ester transfer protein (CETP) DMZN7YT MT DTT DMZN7YT MA Inhibitor DMZN7YT RN Discovery of new cholesteryl ester transfer protein inhibitors via ligand-based pharmacophore modeling and QSAR analysis followed by synthetic expl... Eur J Med Chem. 2010 Apr;45(4):1598-617. DMZN7YT RU https://pubmed.ncbi.nlm.nih.gov/20116902 DM96ATK DI DM96ATK DM96ATK DN SC-83157 DM96ATK MI TTCIHJA DM96ATK MN Coagulation factor Xa (F10) DM96ATK MT DTT DM96ATK MA Inhibitor DM96ATK RN Pharmacological intervention at disparate sites in the coagulation cascade: comparison of anti-thrombotic efficacy vs bleeding propensity in a rat model of acute arterial thrombosis. J Thromb Thrombolysis. 2002 Oct;14(2):113-21. DM96ATK RU https://pubmed.ncbi.nlm.nih.gov/12714830 DMX40NM DI DMX40NM DMX40NM DN SCANDENOLIDE DMX40NM MI TTSXVID DMX40NM MN Nuclear factor NF-kappa-B (NFKB) DMX40NM MT DTT DMX40NM MA Inhibitor DMX40NM RN Quantitative structure-activity relationship of sesquiterpene lactones as inhibitors of the transcription factor NF-kappaB. J Med Chem. 2004 Nov 18;47(24):6042-54. DMX40NM RU https://pubmed.ncbi.nlm.nih.gov/15537359 DMRC4LE DI DMRC4LE DMRC4LE DN Sch 202596 DMRC4LE MI TTOPAY7 DMRC4LE MN Galanin receptor (GAL-R) DMRC4LE MT DTT DMRC4LE MA Antagonist DMRC4LE RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 245). DMRC4LE RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=245 DMD1M24 DI DMD1M24 DMD1M24 DN SCH 206272 DMD1M24 MI TTBPGLU DMD1M24 MN Neuromedin-K receptor (TACR3) DMD1M24 MT DTT DMD1M24 MA Antagonist DMD1M24 RN SCH 206272: a potent, orally active tachykinin NK(1), NK(2), and NK(3) receptor antagonist. Eur J Pharmacol. 2002 Aug 23;450(2):191-202. DMD1M24 RU https://pubmed.ncbi.nlm.nih.gov/12206858 DMD1M24 DI DMD1M24 DMD1M24 DN SCH 206272 DMD1M24 MI TTYO0A3 DMD1M24 MN Substance-K receptor (TACR2) DMD1M24 MT DTT DMD1M24 MA Antagonist DMD1M24 RN SCH 206272: a potent, orally active tachykinin NK(1), NK(2), and NK(3) receptor antagonist. Eur J Pharmacol. 2002 Aug 23;450(2):191-202. DMD1M24 RU https://pubmed.ncbi.nlm.nih.gov/12206858 DMD1M24 DI DMD1M24 DMD1M24 DN SCH 206272 DMD1M24 MI TTZPO1L DMD1M24 MN Substance-P receptor (TACR1) DMD1M24 MT DTT DMD1M24 MA Antagonist DMD1M24 RN SCH 206272: a potent, orally active tachykinin NK(1), NK(2), and NK(3) receptor antagonist. Eur J Pharmacol. 2002 Aug 23;450(2):191-202. DMD1M24 RU https://pubmed.ncbi.nlm.nih.gov/12206858 DMNLD6W DI DMNLD6W DMNLD6W DN SCH 44643 DMNLD6W MI TT27K59 DMNLD6W MN Platelet activating factor (PAF) DMNLD6W MT DTT DMNLD6W MA Inhibitor DMNLD6W RN Determination of plasma concentrations of SCH 44643 by a GC method and correlation of plasma concentration and anti-PAF activity in cynomolgus monkeys. J Pharm Biomed Anal. 1996 Dec;15(3):343-7. DMNLD6W RU https://pubmed.ncbi.nlm.nih.gov/8951694 DMIKJLP DI DMIKJLP DMIKJLP DN Sch-036 DMIKJLP MI TTMSFAW DMIKJLP MN Cannabinoid receptor 2 (CB2) DMIKJLP MT DTT DMIKJLP MA Agonist DMIKJLP RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 57). DMIKJLP RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=57 DMP8OKA DI DMP8OKA DMP8OKA DN SCH-12679 DMP8OKA MI TTZFYLI DMP8OKA MN Dopamine D1 receptor (D1R) DMP8OKA MT DTT DMP8OKA MA Inhibitor DMP8OKA RN Modified ibogaine fragments: synthesis and preliminary pharmacological characterization of 3-ethyl-5-phenyl-1,2,3,4,5, 6-hexahydroazepino[4,5-b]ben... J Med Chem. 1998 Nov 5;41(23):4486-91. DMP8OKA RU https://pubmed.ncbi.nlm.nih.gov/9804688 DM584T6 DI DM584T6 DM584T6 DN SCH-205831 DM584T6 MI TTL935N DM584T6 MN Proteinase activated receptor 1 (F2R) DM584T6 MT DTT DM584T6 MA Inhibitor DM584T6 RN Himbacine derived thrombin receptor (PAR-1) antagonists: SAR of the pyridine ring. Bioorg Med Chem Lett. 2007 Aug 15;17(16):4509-13. DM584T6 RU https://pubmed.ncbi.nlm.nih.gov/17574850 DM42A1F DI DM42A1F DM42A1F DN SCH-210971 DM42A1F MI TT2CEJG DM42A1F MN C-C chemokine receptor type 5 (CCR5) DM42A1F MT DTT DM42A1F MA Inhibitor DM42A1F RN Chemokine receptor CCR-5 inhibitors produced by Chaetomium globosum. J Nat Prod. 2006 Jul;69(7):1025-8. DM42A1F RU https://pubmed.ncbi.nlm.nih.gov/16872138 DMHOUSR DI DMHOUSR DMHOUSR DN SCH-221510 DMHOUSR MI TTNT7K8 DMHOUSR MN Nociceptin receptor (OPRL1) DMHOUSR MT DTT DMHOUSR MA Agonist DMHOUSR RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 320). DMHOUSR RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=320 DMH7EWZ DI DMH7EWZ DMH7EWZ DN SCH-225336 DMH7EWZ MI TTMSFAW DMH7EWZ MN Cannabinoid receptor 2 (CB2) DMH7EWZ MT DTT DMH7EWZ MA Inhibitor DMH7EWZ RN Radiosynthesis of novel carbon-11-labeled triaryl ligands for cannabinoid-type 2 receptor. Bioorg Med Chem Lett. 2010 Mar 1;20(5):1565-8. DMH7EWZ RU https://pubmed.ncbi.nlm.nih.gov/20137936 DMT1OAH DI DMT1OAH DMT1OAH DN SCH-23390 DMT1OAH MI TTZFYLI DMT1OAH MN Dopamine D1 receptor (D1R) DMT1OAH MT DTT DMT1OAH MA Antagonist DMT1OAH RN Dopamine modulates effort-based decision making in rats. Behav Neurosci. 2009 Apr;123(2):242-51. DMT1OAH RU https://pubmed.ncbi.nlm.nih.gov/19331447 DM6SC5K DI DM6SC5K DM6SC5K DN SCH-24518 DM6SC5K MI TTZFYLI DM6SC5K MN Dopamine D1 receptor (D1R) DM6SC5K MT DTT DM6SC5K MA Inhibitor DM6SC5K RN Synthesis and pharmacological characterization of 1-phenyl-, 4-phenyl-, and 1-benzyl-1,2,3,4-tetrahydroisoquinolines as dopamine receptor ligands. J Med Chem. 1988 Oct;31(10):1941-6. DM6SC5K RU https://pubmed.ncbi.nlm.nih.gov/3050089 DM6SC5K DI DM6SC5K DM6SC5K DN SCH-24518 DM6SC5K MI TTEX248 DM6SC5K MN Dopamine D2 receptor (D2R) DM6SC5K MT DTT DM6SC5K MA Inhibitor DM6SC5K RN Synthesis and pharmacological characterization of 1-phenyl-, 4-phenyl-, and 1-benzyl-1,2,3,4-tetrahydroisoquinolines as dopamine receptor ligands. J Med Chem. 1988 Oct;31(10):1941-6. DM6SC5K RU https://pubmed.ncbi.nlm.nih.gov/3050089 DMOEB8M DI DMOEB8M DMOEB8M DN SCH-356036 DMOEB8M MI TT6OEDT DMOEB8M MN Cannabinoid receptor 1 (CB1) DMOEB8M MT DTT DMOEB8M MA Inhibitor DMOEB8M RN Synthesis and SAR of novel imidazoles as potent and selective cannabinoid CB2 receptor antagonists with high binding efficiencies. Bioorg Med Chem Lett. 2010 Feb 1;20(3):1084-9. DMOEB8M RU https://pubmed.ncbi.nlm.nih.gov/20031412 DMOEB8M DI DMOEB8M DMOEB8M DN SCH-356036 DMOEB8M MI TTMSFAW DMOEB8M MN Cannabinoid receptor 2 (CB2) DMOEB8M MT DTT DMOEB8M MA Inhibitor DMOEB8M RN Synthesis and SAR of novel imidazoles as potent and selective cannabinoid CB2 receptor antagonists with high binding efficiencies. Bioorg Med Chem Lett. 2010 Feb 1;20(3):1084-9. DMOEB8M RU https://pubmed.ncbi.nlm.nih.gov/20031412 DM0J937 DI DM0J937 DM0J937 DN SCH-48375 DM0J937 MI TTMF541 DM0J937 MN Liver carboxylesterase (CES1) DM0J937 MT DTT DM0J937 MA Inhibitor DM0J937 RN 2-Azetidinones as inhibitors of cholesterol absorption. J Med Chem. 1994 Jun 10;37(12):1733-6. DM0J937 RU https://pubmed.ncbi.nlm.nih.gov/8021912 DMCWSJP DI DMCWSJP DMCWSJP DN SCH51866 DMCWSJP MI TT73TEJ DMCWSJP MN Phosphodiesterase 1A (PDE1A) DMCWSJP MT DTT DMCWSJP MA Inhibitor DMCWSJP RN Antiplatelet and antiproliferative effects of SCH 51866, a novel type 1 and type 5 phosphodiesterase inhibitor. J Cardiovasc Pharmacol. 1996 Dec;28(6):862-9. DMCWSJP RU https://pubmed.ncbi.nlm.nih.gov/8961086 DMCWSJP DI DMCWSJP DMCWSJP DN SCH51866 DMCWSJP MI TT3ZS42 DMCWSJP MN Phosphodiesterase 1B (PDE1B) DMCWSJP MT DTT DMCWSJP MA Inhibitor DMCWSJP RN Antiplatelet and antiproliferative effects of SCH 51866, a novel type 1 and type 5 phosphodiesterase inhibitor. J Cardiovasc Pharmacol. 1996 Dec;28(6):862-9. DMCWSJP RU https://pubmed.ncbi.nlm.nih.gov/8961086 DMCWSJP DI DMCWSJP DMCWSJP DN SCH51866 DMCWSJP MI TTW2HRK DMCWSJP MN Phosphodiesterase 1C (PDE1C) DMCWSJP MT DTT DMCWSJP MA Inhibitor DMCWSJP RN Antiplatelet and antiproliferative effects of SCH 51866, a novel type 1 and type 5 phosphodiesterase inhibitor. J Cardiovasc Pharmacol. 1996 Dec;28(6):862-9. DMCWSJP RU https://pubmed.ncbi.nlm.nih.gov/8961086 DMCWSJP DI DMCWSJP DMCWSJP DN SCH51866 DMCWSJP MI TTJ0IQB DMCWSJP MN Phosphodiesterase 5A (PDE5A) DMCWSJP MT DTT DMCWSJP MA Inhibitor DMCWSJP RN Antiplatelet and antiproliferative effects of SCH 51866, a novel type 1 and type 5 phosphodiesterase inhibitor. J Cardiovasc Pharmacol. 1996 Dec;28(6):862-9. DMCWSJP RU https://pubmed.ncbi.nlm.nih.gov/8961086 DMCWSJP DI DMCWSJP DMCWSJP DN SCH51866 DMCWSJP MI TTWIEY9 DMCWSJP MN Phosphodiesterase 7B (PDE7B) DMCWSJP MT DTT DMCWSJP MA Inhibitor DMCWSJP RN Identification of human PDE7B, a cAMP-specific phosphodiesterase. Biochem Biophys Res Commun. 2000 May 19;271(3):575-83. DMCWSJP RU https://pubmed.ncbi.nlm.nih.gov/10814504 DMCWSJP DI DMCWSJP DMCWSJP DN SCH51866 DMCWSJP MI TTZOEBC DMCWSJP MN Phosphodiesterase 9 (PDE9) DMCWSJP MT DTT DMCWSJP MA Inhibitor DMCWSJP RN Isolation and characterization of PDE9A, a novel human cGMP-specific phosphodiesterase. J Biol Chem. 1998 Jun 19;273(25):15559-64. DMCWSJP RU https://pubmed.ncbi.nlm.nih.gov/9624146 DMMXIB4 DI DMMXIB4 DMMXIB4 DN SCH-546909 DMMXIB4 MI TT7HF4W DMMXIB4 MN Cyclin-dependent kinase 2 (CDK2) DMMXIB4 MT DTT DMMXIB4 MA Inhibitor DMMXIB4 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1973). DMMXIB4 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1973 DMDK8TR DI DMDK8TR DMDK8TR DN SCH-57726 DMDK8TR MI TTJ0IQB DMDK8TR MN Phosphodiesterase 5A (PDE5A) DMDK8TR MT DTT DMDK8TR MA Inhibitor DMDK8TR RN The Gif system as a tool in medicinal chemistry: The oxidation of Sch 57726 under GoAggIII conditions, Bioorg. Med. Chem. Lett. 7(11):1381-1386 (1997). DMDK8TR RU http://www.sciencedirect.com/science/article/pii/S0960894X97002382 DMRDM9S DI DMRDM9S DMRDM9S DN SCH-602539 DMRDM9S MI TTL935N DMRDM9S MN Proteinase activated receptor 1 (F2R) DMRDM9S MT DTT DMRDM9S MA Antagonist DMRDM9S RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 347). DMRDM9S RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=347 DMAUB9F DI DMAUB9F DMAUB9F DN SCH-63390 DMAUB9F MI TTK25J1 DMAUB9F MN Adenosine A1 receptor (ADORA1) DMAUB9F MT DTT DMAUB9F MA Inhibitor DMAUB9F RN Design, synthesis, and biological evaluation of a second generation of pyrazolo[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidines as potent and selective A2A... J Med Chem. 1998 Jun 4;41(12):2126-33. DMAUB9F RU https://pubmed.ncbi.nlm.nih.gov/9622554 DMAUB9F DI DMAUB9F DMAUB9F DN SCH-63390 DMAUB9F MI TTM2AOE DMAUB9F MN Adenosine A2a receptor (ADORA2A) DMAUB9F MT DTT DMAUB9F MA Inhibitor DMAUB9F RN Design, synthesis, and biological evaluation of a second generation of pyrazolo[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidines as potent and selective A2A... J Med Chem. 1998 Jun 4;41(12):2126-33. DMAUB9F RU https://pubmed.ncbi.nlm.nih.gov/9622554 DM4CI57 DI DM4CI57 DM4CI57 DN SCH-68631 DM4CI57 MI TTWXB3E DM4CI57 MN Hepatitis C virus NS3 helicase (HCV NS3) DM4CI57 MT DTT DM4CI57 MA Inhibitor DM4CI57 RN Control of hepatitis C: a medicinal chemistry perspective. J Med Chem. 2005 Jan 13;48(1):1-20. DM4CI57 RU https://pubmed.ncbi.nlm.nih.gov/15633995 DM9YJI8 DI DM9YJI8 DM9YJI8 DN SCH-725737 DM9YJI8 MI TT90XZ8 DM9YJI8 MN Voltage-gated sodium channel alpha Nav1.8 (SCN10A) DM9YJI8 MT DTT DM9YJI8 MA Inhibitor DM9YJI8 RN Novel steroidal saponins, Sch 725737 and Sch 725739, from a marine starfish, Novodinia antillensis. Bioorg Med Chem Lett. 2007 Oct 15;17(20):5543-7. DM9YJI8 RU https://pubmed.ncbi.nlm.nih.gov/17804230 DMYKB0S DI DMYKB0S DMYKB0S DN SCH-725739 DMYKB0S MI TT90XZ8 DMYKB0S MN Voltage-gated sodium channel alpha Nav1.8 (SCN10A) DMYKB0S MT DTT DMYKB0S MA Inhibitor DMYKB0S RN Novel steroidal saponins, Sch 725737 and Sch 725739, from a marine starfish, Novodinia antillensis. Bioorg Med Chem Lett. 2007 Oct 15;17(20):5543-7. DMYKB0S RU https://pubmed.ncbi.nlm.nih.gov/17804230 DMWVH62 DI DMWVH62 DMWVH62 DN SCH772984 DMWVH62 MI TT4TQBX DMWVH62 MN Extracellular signal-regulated kinase 2 (ERK2) DMWVH62 MT DTT DMWVH62 MA Inhibitor DMWVH62 RN Discovery of a novel ERK inhibitor with activity in models of acquired resistance to BRAF and MEK inhibitors. Cancer Discov. 2013 Jul;3(7):742-50. DMWVH62 RU https://pubmed.ncbi.nlm.nih.gov/23614898 DM5ZEPD DI DM5ZEPD DM5ZEPD DN SCH79687 DM5ZEPD MI TT9JNIC DM5ZEPD MN Histamine H3 receptor (H3R) DM5ZEPD MT DTT DM5ZEPD MA Antagonist DM5ZEPD RN The histamine H3 receptor: from gene cloning to H3 receptor drugs. Nat Rev Drug Discov. 2005 Feb;4(2):107-20. DM5ZEPD RU https://pubmed.ncbi.nlm.nih.gov/15665857 DM346KA DI DM346KA DM346KA DN Sch-900875 DM346KA MI TT1UCIJ DM346KA MN C-X-C chemokine receptor type 3 (CXCR3) DM346KA MT DTT DM346KA MA Antagonist DM346KA RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 70). DM346KA RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=70 DMWQ480 DI DMWQ480 DMWQ480 DN schisandrin A DMWQ480 MI TT7LCTF DMWQ480 MN Pregnane X receptor (NR1I2) DMWQ480 MT DTT DMWQ480 MA Agonist DMWQ480 RN Traditional Chinese medicines Wu Wei Zi (Schisandra chinensis Baill) and Gan Cao (Glycyrrhiza uralensis Fisch) activate pregnane X receptor and inc... J Pharmacol Exp Ther. 2006 Mar;316(3):1369-77. DMWQ480 RU https://pubmed.ncbi.nlm.nih.gov/16267138 DM645FP DI DM645FP DM645FP DN SCOPOLETIN DM645FP MI TTN9T81 DM645FP MN Arachidonate 15-lipoxygenase (15-LOX) DM645FP MT DTT DM645FP MA Inhibitor DM645FP RN Lipoxygenase inhibitory constituents of the fruits of noni (Morinda citrifolia) collected in Tahiti. J Nat Prod. 2007 May;70(5):859-62. DM645FP RU https://pubmed.ncbi.nlm.nih.gov/17378609 DMJD03I DI DMJD03I DMJD03I DN SCUTELLAREIN DMJD03I MI TT7RJY8 DMJD03I MN Xanthine dehydrogenase/oxidase (XDH) DMJD03I MT DTT DMJD03I MA Inhibitor DMJD03I RN Inhibition of cow's milk xanthine oxidase by flavonoids. J Nat Prod. 1988 Mar-Apr;51(2):345-8. DMJD03I RU https://pubmed.ncbi.nlm.nih.gov/3379415 DMQXUYH DI DMQXUYH DMQXUYH DN SD-208 DMQXUYH MI TTP4520 DMQXUYH MN TGF-beta receptor type I (TGFBR1) DMQXUYH MT DTT DMQXUYH MA Inhibitor DMQXUYH RN Evaluation of the anti-hepatitis C virus effect of novel potent, selective, and orally bioavailable JNK and VEGFR kinase inhibitors. Bioorg Med Chem Lett. 2007 Apr 1;17(7):1843-9. DMQXUYH RU https://pubmed.ncbi.nlm.nih.gov/17289388 DMP3EXG DI DMP3EXG DMP3EXG DN SDZ-205-557 DMP3EXG MI TT07C3Y DMP3EXG MN 5-HT 4 receptor (HTR4) DMP3EXG MT DTT DMP3EXG MA Modulator DMP3EXG RN SDZ 205-557, a selective antagonist at 5-HT4 receptors in the isolated guinea pig ileum. Eur J Pharmacol. 1991 Aug 6;200(2-3):373-4. DMP3EXG RU https://www.ncbi.nlm.nih.gov/pubmed/1782999 DMLPRU4 DI DMLPRU4 DMLPRU4 DN SDZ-208911 DMLPRU4 MI TTEX248 DMLPRU4 MN Dopamine D2 receptor (D2R) DMLPRU4 MT DTT DMLPRU4 MA Modulator DMLPRU4 RN Effects of the partial dopamine receptor agonists SDZ 208-911, SDZ 208-912 and terguride on central monoamine receptors. A behavioral, biochemical and electrophysiological study. Naunyn SchmiedebergsArch Pharmacol. 1991 Sep;344(3):263-74. DMLPRU4 RU https://pubmed.ncbi.nlm.nih.gov/1683686 DM3GJ07 DI DM3GJ07 DM3GJ07 DN SDZ-PDI-747 DM3GJ07 MI TTV5CGO DM3GJ07 MN Phosphodiesterase 4 (PDE4) DM3GJ07 MT DTT DM3GJ07 MA Modulator DM3GJ07 RN The ChEMBL database in 2017. Nucleic Acids Res. 2017 Jan 4;45(D1):D945-D954. DM3GJ07 RU https://www.ncbi.nlm.nih.gov/pubmed/27899562 DMBYSEM DI DMBYSEM DMBYSEM DN SDZ-PTS-893 DMBYSEM MI TTEPJL5 DMBYSEM MN Parathyroid hormone receptor (PTH2R) DMBYSEM MT DTT DMBYSEM MA Modulator DMBYSEM RN Long-term therapy of ovariectomy-induced osteopenia with parathyroid hormone analog SDZ PTS 893 and bone maintenance in retired breeder rats. Bone. 1999 Nov;25(5):561-9. DMBYSEM RU https://www.ncbi.nlm.nih.gov/pubmed/10574576 DMYSKI0 DI DMYSKI0 DMYSKI0 DN SE RNA DMYSKI0 MI TTWXB3E DMYSKI0 MN Hepatitis C virus NS3 helicase (HCV NS3) DMYSKI0 MT DTT DMYSKI0 RN Therapeutic applications of aptamers. Expert Opin Investig Drugs. 2008 Jan;17(1):43-60. DMYSKI0 RU https://pubmed.ncbi.nlm.nih.gov/18095918 DMSB4WO DI DMSB4WO DMSB4WO DN SEA DMSB4WO MI TT7QNVC DMSB4WO MN Glucose-dependent insulinotropic receptor (GPR119) DMSB4WO MT DTT DMSB4WO MA Agonist DMSB4WO RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 126). DMSB4WO RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=126 DME69PI DI DME69PI DME69PI DN SEA-0400 DME69PI MI TT619TC DME69PI MN Sodium/calcium exchanger (SLC) DME69PI MT DTT DME69PI MA Inhibitor DME69PI RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4617). DME69PI RU http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=4617 DM3VOPQ DI DM3VOPQ DM3VOPQ DN SEBACIC ACID DM3VOPQ MI TTQO71U DM3VOPQ MN Hemoglobin (HB) DM3VOPQ MT DTT DM3VOPQ MA Inhibitor DM3VOPQ RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DM3VOPQ RU https://pubmed.ncbi.nlm.nih.gov/10592235 DM9QSDC DI DM9QSDC DM9QSDC DN Sec-butyl 9H-pyrido[3,4-b]indole-3-carboxylate DM9QSDC MI TT1MPAY DM9QSDC MN GABA(A) receptor alpha-1 (GABRA1) DM9QSDC MT DTT DM9QSDC MA Inhibitor DM9QSDC RN Design, synthesis, and subtype selectivity of 3,6-disubstituted -carbolines at Bz/GABA(A)ergic receptors. SAR and studies directed toward agents f... Bioorg Med Chem. 2010 Nov 1;18(21):7548-64. DM9QSDC RU https://pubmed.ncbi.nlm.nih.gov/20888240 DM9QSDC DI DM9QSDC DM9QSDC DN Sec-butyl 9H-pyrido[3,4-b]indole-3-carboxylate DM9QSDC MI TTBMV1G DM9QSDC MN GABA(A) receptor alpha-2 (GABRA2) DM9QSDC MT DTT DM9QSDC MA Inhibitor DM9QSDC RN Design, synthesis, and subtype selectivity of 3,6-disubstituted -carbolines at Bz/GABA(A)ergic receptors. SAR and studies directed toward agents f... Bioorg Med Chem. 2010 Nov 1;18(21):7548-64. DM9QSDC RU https://pubmed.ncbi.nlm.nih.gov/20888240 DM9QSDC DI DM9QSDC DM9QSDC DN Sec-butyl 9H-pyrido[3,4-b]indole-3-carboxylate DM9QSDC MI TT37EDJ DM9QSDC MN GABA(A) receptor alpha-3 (GABRA3) DM9QSDC MT DTT DM9QSDC MA Inhibitor DM9QSDC RN Design, synthesis, and subtype selectivity of 3,6-disubstituted -carbolines at Bz/GABA(A)ergic receptors. SAR and studies directed toward agents f... Bioorg Med Chem. 2010 Nov 1;18(21):7548-64. DM9QSDC RU https://pubmed.ncbi.nlm.nih.gov/20888240 DM9QSDC DI DM9QSDC DM9QSDC DN Sec-butyl 9H-pyrido[3,4-b]indole-3-carboxylate DM9QSDC MI TTNZPQ1 DM9QSDC MN GABA(A) receptor alpha-5 (GABRA5) DM9QSDC MT DTT DM9QSDC MA Inhibitor DM9QSDC RN Design, synthesis, and subtype selectivity of 3,6-disubstituted -carbolines at Bz/GABA(A)ergic receptors. SAR and studies directed toward agents f... Bioorg Med Chem. 2010 Nov 1;18(21):7548-64. DM9QSDC RU https://pubmed.ncbi.nlm.nih.gov/20888240 DM9QSDC DI DM9QSDC DM9QSDC DN Sec-butyl 9H-pyrido[3,4-b]indole-3-carboxylate DM9QSDC MI TT06RH5 DM9QSDC MN GABA(A) receptor gamma-2 (GABRG2) DM9QSDC MT DTT DM9QSDC MA Inhibitor DM9QSDC RN Design, synthesis, and subtype selectivity of 3,6-disubstituted -carbolines at Bz/GABA(A)ergic receptors. SAR and studies directed toward agents f... Bioorg Med Chem. 2010 Nov 1;18(21):7548-64. DM9QSDC RU https://pubmed.ncbi.nlm.nih.gov/20888240 DM9QSDC DI DM9QSDC DM9QSDC DN Sec-butyl 9H-pyrido[3,4-b]indole-3-carboxylate DM9QSDC MI TTNJYV2 DM9QSDC MN Gamma-aminobutyric acid receptor (GAR) DM9QSDC MT DTT DM9QSDC MA Inhibitor DM9QSDC RN Design, synthesis, and subtype selectivity of 3,6-disubstituted -carbolines at Bz/GABA(A)ergic receptors. SAR and studies directed toward agents f... Bioorg Med Chem. 2010 Nov 1;18(21):7548-64. DM9QSDC RU https://pubmed.ncbi.nlm.nih.gov/20888240 DM76CUP DI DM76CUP DM76CUP DN SECOCULARIDINE DM76CUP MI TTVBI8W DM76CUP MN Dopamine transporter (DAT) DM76CUP MT DTT DM76CUP MA Inhibitor DM76CUP RN Effects of various isoquinoline alkaloids on in vitro 3H-dopamine uptake by rat striatal synaptosomes. J Nat Prod. 1995 Oct;58(10):1475-84. DM76CUP RU https://pubmed.ncbi.nlm.nih.gov/8676127 DMY7IVZ DI DMY7IVZ DMY7IVZ DN Seco-exiguamine DMY7IVZ MI TTZJYKH DMY7IVZ MN Indoleamine 2,3-dioxygenase 1 (IDO1) DMY7IVZ MT DTT DMY7IVZ MA Inhibitor DMY7IVZ RN Biomimetic synthesis of the IDO inhibitors exiguamine A and B. Nat Chem Biol. 2008 Sep;4(9):535-7. DMY7IVZ RU https://pubmed.ncbi.nlm.nih.gov/18677305 DM9BJ27 DI DM9BJ27 DM9BJ27 DN Se-Ethyl-Isoselenourea DM9BJ27 MI TTCM4B3 DM9BJ27 MN Nitric-oxide synthase endothelial (NOS3) DM9BJ27 MT DTT DM9BJ27 MA Inhibitor DM9BJ27 RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DM9BJ27 RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMCQNT9 DI DMCQNT9 DMCQNT9 DN SE-ET-TP020d DMCQNT9 MI TTIHYA4 DMCQNT9 MN Thrombopoietin receptor (MPL) DMCQNT9 MT DTT DMCQNT9 MA Modulator DMCQNT9 RN The ChEMBL database in 2017. Nucleic Acids Res. 2017 Jan 4;45(D1):D945-D954. DMCQNT9 RU https://www.ncbi.nlm.nih.gov/pubmed/27899562 DMFKE6C DI DMFKE6C DMFKE6C DN SEL-73 DMFKE6C MI TTSQIFT DMFKE6C MN 5-HT 1A receptor (HTR1A) DMFKE6C MT DTT DMFKE6C MA Modulator DMFKE6C RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1). DMFKE6C RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1 DMFKE6C DI DMFKE6C DMFKE6C DN SEL-73 DMFKE6C MI TTJQOD7 DMFKE6C MN 5-HT 2A receptor (HTR2A) DMFKE6C MT DTT DMFKE6C MA Modulator DMFKE6C RN Pharmacological profile of the new potent neuroleptic ocaperidone (R 79,598). J Pharmacol Exp Ther. 1992 Jan;260(1):146-59. DMFKE6C RU https://pubmed.ncbi.nlm.nih.gov/1370538 DMFKE6C DI DMFKE6C DMFKE6C DN SEL-73 DMFKE6C MI TTJS8PY DMFKE6C MN 5-HT 6 receptor (HTR6) DMFKE6C MT DTT DMFKE6C MA Modulator DMFKE6C RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 11). DMFKE6C RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=11 DMFKE6C DI DMFKE6C DMFKE6C DN SEL-73 DMFKE6C MI TTO9X1H DMFKE6C MN 5-HT 7 receptor (HTR7) DMFKE6C MT DTT DMFKE6C MA Modulator DMFKE6C RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 12). DMFKE6C RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=12 DMFKE6C DI DMFKE6C DMFKE6C DN SEL-73 DMFKE6C MI TTEX248 DMFKE6C MN Dopamine D2 receptor (D2R) DMFKE6C MT DTT DMFKE6C MA Modulator DMFKE6C RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 215). DMFKE6C RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=215 DMKSIVL DI DMKSIVL DMKSIVL DN Selenazofurin DMKSIVL MI TTL7C8Q DMKSIVL MN Inosine-5'-monophosphate dehydrogenase 1 (IMPDH1) DMKSIVL MT DTT DMKSIVL MA Inhibitor DMKSIVL RN In vitro and in vivo antiproliferative activity of IPCAR, a new pyrazole nucleoside analog. Anticancer Res. 1998 Jul-Aug;18(4A):2623-30. DMKSIVL RU https://pubmed.ncbi.nlm.nih.gov/9703919 DMXERWD DI DMXERWD DMXERWD DN Selenazole-4-Carboxyamide-Adenine Dinucleotide DMXERWD MI TTTB4UP DMXERWD MN Inosine-5'-monophosphate dehydrogenase 2 (IMPDH2) DMXERWD MT DTT DMXERWD MA Inhibitor DMXERWD RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMXERWD RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMB7GPA DI DMB7GPA DMB7GPA DN Selenious acid DMB7GPA MI DEUP4DA DMB7GPA MN Thioredoxin reductase TR1 (TXNRD1) DMB7GPA MT DME DMB7GPA MA Metabolism DMB7GPA RN Selenium metabolism, selenoproteins and mechanisms of cancer prevention: complexities with thioredoxin reductase. Carcinogenesis. 1999 Sep;20(9):1657-66. DMB7GPA RU https://www.ncbi.nlm.nih.gov/pubmed/?term=10469608 DMBJ1E0 DI DMBJ1E0 DMBJ1E0 DN Selumetinib DMBJ1E0 MI TTAW3TO DMBJ1E0 MN HUMAN ERK activator kinase 1 (MEK1) DMBJ1E0 MT DTT DMBJ1E0 MA Inhibitor DMBJ1E0 RN Coronaviruses - drug discovery and therapeutic options. Nat Rev Drug Discov. 2016 May;15(5):327-47. DMBJ1E0 RU https://pubmed.ncbi.nlm.nih.gov/26868298 DMBJ1E0 DI DMBJ1E0 DMBJ1E0 DN Selumetinib DMBJ1E0 MI TTWX403 DMBJ1E0 MN HUMAN ERK activator kinase 2 (MEK2) DMBJ1E0 MT DTT DMBJ1E0 MA Inhibitor DMBJ1E0 RN Coronaviruses - drug discovery and therapeutic options. Nat Rev Drug Discov. 2016 May;15(5):327-47. DMBJ1E0 RU https://pubmed.ncbi.nlm.nih.gov/26868298 DMDIZUT DI DMDIZUT DMDIZUT DN SEM-606 DMDIZUT MI TTE4KHA DMDIZUT MN Amyloid beta A4 protein (APP) DMDIZUT MT DTT DMDIZUT MA Inhibitor DMDIZUT RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2402). DMDIZUT RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2402 DMW5SIQ DI DMW5SIQ DMW5SIQ DN SEMIPLENAMIDE A DMW5SIQ MI TT6OEDT DMW5SIQ MN Cannabinoid receptor 1 (CB1) DMW5SIQ MT DTT DMW5SIQ MA Inhibitor DMW5SIQ RN Semiplenamides A-G, fatty acid amides from a Papua New Guinea collection of the marine cyanobacterium Lyngbya semiplena. J Nat Prod. 2003 Oct;66(10):1364-8. DMW5SIQ RU https://pubmed.ncbi.nlm.nih.gov/14575438 DMHWCFJ DI DMHWCFJ DMHWCFJ DN SEMIPLENAMIDE B DMHWCFJ MI TT6OEDT DMHWCFJ MN Cannabinoid receptor 1 (CB1) DMHWCFJ MT DTT DMHWCFJ MA Inhibitor DMHWCFJ RN Semiplenamides A-G, fatty acid amides from a Papua New Guinea collection of the marine cyanobacterium Lyngbya semiplena. J Nat Prod. 2003 Oct;66(10):1364-8. DMHWCFJ RU https://pubmed.ncbi.nlm.nih.gov/14575438 DM4RP0A DI DM4RP0A DM4RP0A DN Semiplenamide G DM4RP0A MI TT6OEDT DM4RP0A MN Cannabinoid receptor 1 (CB1) DM4RP0A MT DTT DM4RP0A MA Inhibitor DM4RP0A RN Semiplenamides A-G, fatty acid amides from a Papua New Guinea collection of the marine cyanobacterium Lyngbya semiplena. J Nat Prod. 2003 Oct;66(10):1364-8. DM4RP0A RU https://pubmed.ncbi.nlm.nih.gov/14575438 DM1C5GZ DI DM1C5GZ DM1C5GZ DN Semorphone DM1C5GZ MI TTKWM86 DM1C5GZ MN Opioid receptor mu (MOP) DM1C5GZ MT DTT DM1C5GZ MA Modulator DM1C5GZ RN Respiratory effects and tolerability of Mr 2264 Cl.A new opiate partial agonist in comparison with morphine and placebo.Eur J Clin Pharmacol.1994;46(4):301-4. DM1C5GZ RU https://www.ncbi.nlm.nih.gov/pubmed/7957512 DMKB2IJ DI DMKB2IJ DMKB2IJ DN SEN-1500 DMKB2IJ MI TTE4KHA DMKB2IJ MN Amyloid beta A4 protein (APP) DMKB2IJ MT DTT DMKB2IJ MA Inhibitor DMKB2IJ RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2402). DMKB2IJ RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2402 DMRJIP4 DI DMRJIP4 DMRJIP4 DN Septide DMRJIP4 MI TTZPO1L DMRJIP4 MN Substance-P receptor (TACR1) DMRJIP4 MT DTT DMRJIP4 MA Agonist DMRJIP4 RN Septide: an agonist for the NK1 receptor acting at a site distinct from substance P. Mol Pharmacol. 1994 Feb;45(2):287-93. DMRJIP4 RU https://pubmed.ncbi.nlm.nih.gov/7509440 DMIKT7W DI DMIKT7W DMIKT7W DN SER-203 DMIKT7W MI TTGTQHC DMIKT7W MN DNA topoisomerase I (TOP1) DMIKT7W MT DTT DMIKT7W MA Stimulator DMIKT7W RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2636). DMIKT7W RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2636 DMF8GAX DI DMF8GAX DMF8GAX DN sergliflozin DMF8GAX MI TT2UE56 DMF8GAX MN Sodium/glucose cotransporter 1 (SGLT1) DMF8GAX MT DTT DMF8GAX MA Inhibitor DMF8GAX RN Sergliflozin, a novel selective inhibitor of low-affinity sodium glucose cotransporter (SGLT2), validates the critical role of SGLT2 in renal gluco... J Pharmacol Exp Ther. 2007 Jan;320(1):323-30. DMF8GAX RU https://pubmed.ncbi.nlm.nih.gov/17050778 DMF8GAX DI DMF8GAX DMF8GAX DN sergliflozin DMF8GAX MI TTLWPVF DMF8GAX MN Sodium/glucose cotransporter 2 (SGLT2) DMF8GAX MT DTT DMF8GAX MA Inhibitor DMF8GAX RN Sergliflozin, a novel selective inhibitor of low-affinity sodium glucose cotransporter (SGLT2), validates the critical role of SGLT2 in renal gluco... J Pharmacol Exp Ther. 2007 Jan;320(1):323-30. DMF8GAX RU https://pubmed.ncbi.nlm.nih.gov/17050778 DM6FVCE DI DM6FVCE DM6FVCE DN Sergliflozin A DM6FVCE MI TTF8JAT DM6FVCE MN SLC5A2 messenger RNA (SLC5A2 mRNA) DM6FVCE MT DTT DM6FVCE MA Inhibitor DM6FVCE RN Novel C-aryl glucoside SGLT2 inhibitors as potential antidiabetic agents: 1,3,4-Thiadiazolylmethylphenyl glucoside congeners. Bioorg Med Chem. 2010 Mar 15;18(6):2178-2194. DM6FVCE RU https://pubmed.ncbi.nlm.nih.gov/20181486 DM4ZYKV DI DM4ZYKV DM4ZYKV DN SERMs DM4ZYKV MI TTZAYWL DM4ZYKV MN Estrogen receptor (ESR) DM4ZYKV MT DTT DM4ZYKV MA Modulator DM4ZYKV RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 620). DM4ZYKV RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=620 DMOFCRY DI DMOFCRY DMOFCRY DN Serotonin DMOFCRY MI TTSQIFT DMOFCRY MN 5-HT 1A receptor (HTR1A) DMOFCRY MT DTT DMOFCRY MA Inhibitor DMOFCRY RN Novel, potent, and selective quinoxaline-based 5-HT(3) receptor ligands. 1. Further structure-activity relationships and pharmacological characteri... J Med Chem. 2009 Nov 12;52(21):6946-50. DMOFCRY RU https://pubmed.ncbi.nlm.nih.gov/19831400 DMOFCRY DI DMOFCRY DMOFCRY DN Serotonin DMOFCRY MI TTK8CXU DMOFCRY MN 5-HT 1B receptor (HTR1B) DMOFCRY MT DTT DMOFCRY MA Inhibitor DMOFCRY RN cis-4-(Piperazin-1-yl)-5,6,7a,8,9,10,11,11a-octahydrobenzofuro[2,3-h]quinazolin-2-amine (A-987306), a new histamine H4R antagonist that blocks pain... J Med Chem. 2008 Nov 27;51(22):7094-8. DMOFCRY RU https://pubmed.ncbi.nlm.nih.gov/18983139 DMOFCRY DI DMOFCRY DMOFCRY DN Serotonin DMOFCRY MI TT6MSOK DMOFCRY MN 5-HT 1D receptor (HTR1D) DMOFCRY MT DTT DMOFCRY MA Inhibitor DMOFCRY RN Designing selective, high affinity ligands of 5-HT1D receptor by covalent dimerization of 5-HT1F ligands derived from 4-fluoro-N-[3-(1-methyl-4-pip... J Med Chem. 2008 Jun 26;51(12):3609-16. DMOFCRY RU https://pubmed.ncbi.nlm.nih.gov/18507369 DMOFCRY DI DMOFCRY DMOFCRY DN Serotonin DMOFCRY MI TTJQOD7 DMOFCRY MN 5-HT 2A receptor (HTR2A) DMOFCRY MT DTT DMOFCRY MA Inhibitor DMOFCRY RN Novel, potent, and selective quinoxaline-based 5-HT(3) receptor ligands. 1. Further structure-activity relationships and pharmacological characteri... J Med Chem. 2009 Nov 12;52(21):6946-50. DMOFCRY RU https://pubmed.ncbi.nlm.nih.gov/19831400 DMOFCRY DI DMOFCRY DMOFCRY DN Serotonin DMOFCRY MI TT0K1SC DMOFCRY MN 5-HT 2B receptor (HTR2B) DMOFCRY MT DTT DMOFCRY MA Inhibitor DMOFCRY RN Pyrrolo(iso)quinoline derivatives as 5-HT(2C) receptor agonists. Bioorg Med Chem Lett. 2006 Feb;16(3):677-80. DMOFCRY RU https://pubmed.ncbi.nlm.nih.gov/16257207 DMOFCRY DI DMOFCRY DMOFCRY DN Serotonin DMOFCRY MI TTWJBZ5 DMOFCRY MN 5-HT 2C receptor (HTR2C) DMOFCRY MT DTT DMOFCRY MA Inhibitor DMOFCRY RN Brominated cyclodipeptides from the marine sponge Geodia barretti as selective 5-HT ligands. J Nat Prod. 2006 Oct;69(10):1421-4. DMOFCRY RU https://pubmed.ncbi.nlm.nih.gov/17067154 DMOFCRY DI DMOFCRY DMOFCRY DN Serotonin DMOFCRY MI TTPC4TU DMOFCRY MN 5-HT 3A receptor (HTR3A) DMOFCRY MT DTT DMOFCRY MA Inhibitor DMOFCRY RN Novel potent and selective central 5-HT3 receptor ligands provided with different intrinsic efficacy. 2. Molecular basis of the intrinsic efficacy ... J Med Chem. 1999 May 6;42(9):1556-75. DMOFCRY RU https://pubmed.ncbi.nlm.nih.gov/10229626 DMOFCRY DI DMOFCRY DMOFCRY DN Serotonin DMOFCRY MI TTR6K75 DMOFCRY MN 5-HT 3B receptor (HTR3B) DMOFCRY MT DTT DMOFCRY MA Inhibitor DMOFCRY RN Novel potent and selective central 5-HT3 receptor ligands provided with different intrinsic efficacy. 2. Molecular basis of the intrinsic efficacy ... J Med Chem. 1999 May 6;42(9):1556-75. DMOFCRY RU https://pubmed.ncbi.nlm.nih.gov/10229626 DMOFCRY DI DMOFCRY DMOFCRY DN Serotonin DMOFCRY MI TT07C3Y DMOFCRY MN 5-HT 4 receptor (HTR4) DMOFCRY MT DTT DMOFCRY MA Inhibitor DMOFCRY RN Brominated cyclodipeptides from the marine sponge Geodia barretti as selective 5-HT ligands. J Nat Prod. 2006 Oct;69(10):1421-4. DMOFCRY RU https://pubmed.ncbi.nlm.nih.gov/17067154 DMOFCRY DI DMOFCRY DMOFCRY DN Serotonin DMOFCRY MI TTRUFDT DMOFCRY MN 5-HT 5A receptor (HTR5A) DMOFCRY MT DTT DMOFCRY MA Inhibitor DMOFCRY RN Identification of a potent, selective, and orally active leukotriene a4 hydrolase inhibitor with anti-inflammatory activity. J Med Chem. 2008 Jul 24;51(14):4150-69. DMOFCRY RU https://pubmed.ncbi.nlm.nih.gov/18588282 DMOFCRY DI DMOFCRY DMOFCRY DN Serotonin DMOFCRY MI TTJS8PY DMOFCRY MN 5-HT 6 receptor (HTR6) DMOFCRY MT DTT DMOFCRY MA Inhibitor DMOFCRY RN 5-Cyclic amine-3-arylsulfonylindazoles as novel 5-HT6 receptor antagonists. J Med Chem. 2010 Mar 25;53(6):2521-7. DMOFCRY RU https://pubmed.ncbi.nlm.nih.gov/20170099 DMOFCRY DI DMOFCRY DMOFCRY DN Serotonin DMOFCRY MI TTO9X1H DMOFCRY MN 5-HT 7 receptor (HTR7) DMOFCRY MT DTT DMOFCRY MA Inhibitor DMOFCRY RN Identification of a potent, selective, and orally active leukotriene a4 hydrolase inhibitor with anti-inflammatory activity. J Med Chem. 2008 Jul 24;51(14):4150-69. DMOFCRY RU https://pubmed.ncbi.nlm.nih.gov/18588282 DMOFCRY DI DMOFCRY DMOFCRY DN Serotonin DMOFCRY MI TTJFY5U DMOFCRY MN Adenosine A3 receptor (ADORA3) DMOFCRY MT DTT DMOFCRY MA Inhibitor DMOFCRY RN 2-n-Butyl-9-methyl-8-[1,2,3]triazol-2-yl-9H-purin-6-ylamine and analogues as A2A adenosine receptor antagonists. Design, synthesis, and pharmacolog... J Med Chem. 2005 Nov 3;48(22):6887-96. DMOFCRY RU https://pubmed.ncbi.nlm.nih.gov/16250647 DMOFCRY DI DMOFCRY DMOFCRY DN Serotonin DMOFCRY MI DT3EAQP DMOFCRY MN Equilibrative nucleoside transporter 4 (SLC29A4) DMOFCRY MT DTP DMOFCRY MA Substrate DMOFCRY RN Autism spectrum disorder associated with low serotonin in CSF and mutations in the SLC29A4 plasma membrane monoamine transporter (PMAT) gene. Mol Autism. 2014 Aug 13;5:43. DMOFCRY RU http://www.ncbi.nlm.nih.gov/pubmed/25802735 DMOFCRY DI DMOFCRY DMOFCRY DN Serotonin DMOFCRY MI DERE4TU DMOFCRY MN Monoamine oxidase type A (MAO-A) DMOFCRY MT DME DMOFCRY MA Metabolism DMOFCRY RN Do monomeric vs dimeric forms of MAO-A make a difference? A direct comparison of the catalytic properties of rat and human MAO-A's. J Neural Transm (Vienna). 2007;114(6):721-4. DMOFCRY RU https://www.ncbi.nlm.nih.gov/pubmed/?term=17401534 DMOFCRY DI DMOFCRY DMOFCRY DN Serotonin DMOFCRY MI DT9IDPW DMOFCRY MN Organic cation transporter 2 (SLC22A2) DMOFCRY MT DTP DMOFCRY MA Substrate DMOFCRY RN Differential pharmacological in vitro properties of organic cation transporters and regional distribution in rat brain. Neuropharmacology. 2006 Jun;50(8):941-52. DMOFCRY RU http://www.ncbi.nlm.nih.gov/pubmed/16581093 DMOFCRY DI DMOFCRY DMOFCRY DN Serotonin DMOFCRY MI DTAV4SY DMOFCRY MN Sodium-dependent serotonin transporter (SLC6A4) DMOFCRY MT DTP DMOFCRY MA Substrate DMOFCRY RN Serotonin transporter gene, depressive symptoms, and interleukin-6. Circ Cardiovasc Genet. 2009 Dec;2(6):614-20. DMOFCRY RU http://www.ncbi.nlm.nih.gov/pubmed/20031642 DMOFCRY DI DMOFCRY DMOFCRY DN Serotonin DMOFCRY MI DTM953D DMOFCRY MN Vesicular amine transporter 1 (SLC18A1) DMOFCRY MT DTP DMOFCRY MA Substrate DMOFCRY RN SLC18: Vesicular neurotransmitter transporters for monoamines and acetylcholine. Mol Aspects Med. 2013 Apr-Jun;34(2-3):360-72. DMOFCRY RU http://www.ncbi.nlm.nih.gov/pubmed/23506877 DMOFCRY DI DMOFCRY DMOFCRY DN Serotonin DMOFCRY MI DTT7VPB DMOFCRY MN Vesicular amine transporter 2 (SLC18A2) DMOFCRY MT DTP DMOFCRY MA Substrate DMOFCRY RN SLC18: Vesicular neurotransmitter transporters for monoamines and acetylcholine. Mol Aspects Med. 2013 Apr-Jun;34(2-3):360-72. DMOFCRY RU http://www.ncbi.nlm.nih.gov/pubmed/23506877 DMS509U DI DMS509U DMS509U DN Ser-Tyr-Ser-Nle-Glu-His-Dphe-Arg DMS509U MI TTD0CIQ DMS509U MN Melanocortin receptor 4 (MC4R) DMS509U MT DTT DMS509U MA Inhibitor DMS509U RN Squalene-derived flexible linkers for bioactive peptides. Bioorg Med Chem Lett. 2007 Jun 15;17(12):3310-3. DMS509U RU https://pubmed.ncbi.nlm.nih.gov/17448660 DM49AYM DI DM49AYM DM49AYM DN S-Ethyl-N-[4-(Trifluoromethyl)Phenyl]Isothiourea DM49AYM MI TTZUFI5 DM49AYM MN Nitric-oxide synthase brain (NOS1) DM49AYM MT DTT DM49AYM MA Inhibitor DM49AYM RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DM49AYM RU https://pubmed.ncbi.nlm.nih.gov/10592235 DM6DT9Z DI DM6DT9Z DM6DT9Z DN S-Ethyl-N-Phenyl-Isothiourea DM6DT9Z MI TTZUFI5 DM6DT9Z MN Nitric-oxide synthase brain (NOS1) DM6DT9Z MT DTT DM6DT9Z MA Inhibitor DM6DT9Z RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DM6DT9Z RU https://pubmed.ncbi.nlm.nih.gov/10592235 DM6DT9Z DI DM6DT9Z DM6DT9Z DN S-Ethyl-N-Phenyl-Isothiourea DM6DT9Z MI TTCM4B3 DM6DT9Z MN Nitric-oxide synthase endothelial (NOS3) DM6DT9Z MT DTT DM6DT9Z MA Inhibitor DM6DT9Z RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DM6DT9Z RU https://pubmed.ncbi.nlm.nih.gov/10592235 DMJBW7X DI DMJBW7X DMJBW7X DN SEW2871 DMJBW7X MI TT9JZCK DMJBW7X MN Sphingosine-1-phosphate receptor 1 (S1PR1) DMJBW7X MT DTT DMJBW7X MA Agonist DMJBW7X RN Sphingosine 1-phosphate (S1P) receptor subtypes S1P1 and S1P3, respectively, regulate lymphocyte recirculation and heart rate. J Biol Chem. 2004 Apr 2;279(14):13839-48. DMJBW7X RU https://pubmed.ncbi.nlm.nih.gov/14732717 DMVI2H9 DI DMVI2H9 DMVI2H9 DN SF-11 DMVI2H9 MI TT0NLAQ DMVI2H9 MN Mucolipin-3 (TRPML3) DMVI2H9 MT DTT DMVI2H9 MA Activator DMVI2H9 RN Small molecule activators of TRPML3. Chem Biol. 2010 Feb 26;17(2):135-48. DMVI2H9 RU https://pubmed.ncbi.nlm.nih.gov/20189104 DMI6SNQ DI DMI6SNQ DMI6SNQ DN SF-21 DMI6SNQ MI TT0NLAQ DMI6SNQ MN Mucolipin-3 (TRPML3) DMI6SNQ MT DTT DMI6SNQ MA Activator DMI6SNQ RN Small molecule activators of TRPML3. Chem Biol. 2010 Feb 26;17(2):135-48. DMI6SNQ RU https://pubmed.ncbi.nlm.nih.gov/20189104 DMH36A9 DI DMH36A9 DMH36A9 DN SF303 DMH36A9 MI TTCIHJA DMH36A9 MN Coagulation factor Xa (F10) DMH36A9 MT DTT DMH36A9 MA Inhibitor DMH36A9 RN The design and synthesis of noncovalent factor Xa inhibitors. Curr Top Med Chem. 2001 Jun;1(2):137-49. DMH36A9 RU https://pubmed.ncbi.nlm.nih.gov/11899249 DMP35VS DI DMP35VS DMP35VS DN SGC0946 DMP35VS MI TTSZ8T1 DMP35VS MN Histone-lysine N-methyltransferase (HLNM) DMP35VS MT DTT DMP35VS MA Inhibitor DMP35VS RN Catalytic site remodelling of the DOT1L methyltransferase by selective inhibitors. Nat Commun. 2012;3:1288. DMP35VS RU https://pubmed.ncbi.nlm.nih.gov/23250418 DMGINBT DI DMGINBT DMGINBT DN SGC707 DMGINBT MI TTL4XSQ DMGINBT MN Protein arginine methyltransferase 3 (PRMT3) DMGINBT MT DTT DMGINBT MA Modulator (allosteric modulator) DMGINBT RN A potent, selective and cell-active allosteric inhibitor of protein arginine methyltransferase (PRMT3). Angew Chem Int Ed Engl. 2015 Apr 20;54(17):5166-70. DMGINBT RU https://pubmed.ncbi.nlm.nih.gov/25728001 DMTLRGZ DI DMTLRGZ DMTLRGZ DN SGC-CBP30 DMTLRGZ MI TTFRCTK DMTLRGZ MN CREB-binding protein (CREBBP) DMTLRGZ MT DTT DMTLRGZ MA Inhibitor DMTLRGZ RN Bromodomains and their pharmacological inhibitors. ChemMedChem. 2014 Mar;9(3):438-64. DMTLRGZ RU https://pubmed.ncbi.nlm.nih.gov/24497428 DMTLRGZ DI DMTLRGZ DMTLRGZ DN SGC-CBP30 DMTLRGZ MI TTH4VJL DMTLRGZ MN Histone acetyltransferase KAT6B (KAT6B) DMTLRGZ MT DTT DMTLRGZ MA Inhibitor DMTLRGZ RN Bromodomains and their pharmacological inhibitors. ChemMedChem. 2014 Mar;9(3):438-64. DMTLRGZ RU https://pubmed.ncbi.nlm.nih.gov/24497428 DMZ20A5 DI DMZ20A5 DMZ20A5 DN SGI-1252 DMZ20A5 MI TTRMX3V DMZ20A5 MN Janus kinase 2 (JAK-2) DMZ20A5 MT DTT DMZ20A5 MA Inhibitor DMZ20A5 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2048). DMZ20A5 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2048 DMW7E32 DI DMW7E32 DMW7E32 DN SHA 68 DMW7E32 MI TTV1C0Z DMW7E32 MN Neuropeptide S receptor (NPSR) DMW7E32 MT DTT DMW7E32 MA Antagonist DMW7E32 RN Further studies on the pharmacological profile of the neuropeptide S receptor antagonist SHA 68. Peptides. 2010 May;31(5):915-25. DMW7E32 RU https://pubmed.ncbi.nlm.nih.gov/20172007 DMODS9A DI DMODS9A DMODS9A DN S-hexyl hexane-1-sulfinothioate DMODS9A MI TT2SUAQ DMODS9A MN Cysteine protease (CYP) DMODS9A MT DTT DMODS9A MA Inhibitor DMODS9A RN Allicin and derivates are cysteine protease inhibitors with antiparasitic activity. Bioorg Med Chem Lett. 2010 Sep 15;20(18):5541-3. DMODS9A RU https://pubmed.ncbi.nlm.nih.gov/20692829 DMNWP02 DI DMNWP02 DMNWP02 DN S-hexylglutathione DMNWP02 MI TTCYE56 DMNWP02 MN Glutathione-dependent PGD synthase (HPGDS) DMNWP02 MT DTT DMNWP02 MA Inhibitor DMNWP02 RN Purification and catalytic properties of glutathione transferase from the hepatopancreas of crayfish macrobrachium vollenhovenii (herklots). J Biochem Mol Toxicol. 2004;18(6):332-44. DMNWP02 RU https://pubmed.ncbi.nlm.nih.gov/15674845 DMBE0CT DI DMBE0CT DMBE0CT DN Shikimate-3-Phosphate DMBE0CT MI TTB30PF DMBE0CT MN Bacterial Phosphoshikimate1-carboxyvinyltransferase (Bact aroA) DMBE0CT MT DTT DMBE0CT MA Inhibitor DMBE0CT RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMBE0CT RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMTKHR3 DI DMTKHR3 DMTKHR3 DN ShRNA molecule silencing DNAPK radiosensitizer DMTKHR3 MI TTK3PY9 DMTKHR3 MN DNA-dependent protein kinase catalytic (PRKDC) DMTKHR3 MT DTT DMTKHR3 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2800). DMTKHR3 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2800 DMT62LS DI DMT62LS DMT62LS DN SHU9119 DMT62LS MI TTNI91K DMT62LS MN Melanocortin receptor 3 (MC3R) DMT62LS MT DTT DMT62LS MA Antagonist DMT62LS RN Activation of melanocortin type 3 receptor as a molecular mechanism for adrenocorticotropic hormone efficacy in gouty arthritis. Arthritis Rheum. 2002 Oct;46(10):2765-75. DMT62LS RU https://pubmed.ncbi.nlm.nih.gov/12384937 DMAEY9X DI DMAEY9X DMAEY9X DN Sialic acid DMAEY9X MI DE3OGM0 DMAEY9X MN N-acetylneuraminate lyase (nanA) DMAEY9X MT DME DMAEY9X MA Metabolism DMAEY9X RN Crystal structures and kinetics of N-acetylneuraminate lyase from Fusobacterium nucleatum. Acta Crystallogr F Struct Biol Commun. 2018 Nov 1;74(Pt 11):725-732. DMAEY9X RU https://pubmed.ncbi.nlm.nih.gov/30387778 DMR5FD9 DI DMR5FD9 DMR5FD9 DN Sib-1533A DMR5FD9 MI TTMT0HG DMR5FD9 MN Neuronal acetylcholine receptor alpha-2/alpha-3 (CHRNA2/A3) DMR5FD9 MT DTT DMR5FD9 MA Agonist DMR5FD9 RN Nicotine, brain nicotinic receptors, and neuropsychiatric disorders. Arch Med Res. 2000 Mar-Apr;31(2):131-44. DMR5FD9 RU https://pubmed.ncbi.nlm.nih.gov/10880717 DMFOGE2 DI DMFOGE2 DMFOGE2 DN SIB-1757 DMFOGE2 MI TTHS256 DMFOGE2 MN Metabotropic glutamate receptor 5 (mGluR5) DMFOGE2 MT DTT DMFOGE2 MA Inhibitor DMFOGE2 RN Design and synthesis of noncompetitive metabotropic glutamate receptor subtype 5 antagonists. Bioorg Med Chem Lett. 2006 Jul 1;16(13):3371-5. DMFOGE2 RU https://pubmed.ncbi.nlm.nih.gov/16678408 DMAVBKP DI DMAVBKP DMAVBKP DN SIB-1893 DMAVBKP MI TTHS256 DMAVBKP MN Metabotropic glutamate receptor 5 (mGluR5) DMAVBKP MT DTT DMAVBKP MA Inhibitor DMAVBKP RN Design and synthesis of noncompetitive metabotropic glutamate receptor subtype 5 antagonists. Bioorg Med Chem Lett. 2006 Jul 1;16(13):3371-5. DMAVBKP RU https://pubmed.ncbi.nlm.nih.gov/16678408 DMEIBTY DI DMEIBTY DMEIBTY DN SIDEROXYLONAL A DMEIBTY MI TTTO43N DMEIBTY MN Endothelial plasminogen activator inhibitor (SERPINE1) DMEIBTY MT DTT DMEIBTY MA Inhibitor DMEIBTY RN Sideroxylonal C, a new inhibitor of human plasminogen activator inhibitor type-1, from the flowers of Eucalyptus albens. J Nat Prod. 1999 Feb;62(2):324-6. DMEIBTY RU https://pubmed.ncbi.nlm.nih.gov/10075775 DMDP7Y5 DI DMDP7Y5 DMDP7Y5 DN SIDEROXYLONAL B DMDP7Y5 MI TTTO43N DMDP7Y5 MN Endothelial plasminogen activator inhibitor (SERPINE1) DMDP7Y5 MT DTT DMDP7Y5 MA Inhibitor DMDP7Y5 RN Sideroxylonal C, a new inhibitor of human plasminogen activator inhibitor type-1, from the flowers of Eucalyptus albens. J Nat Prod. 1999 Feb;62(2):324-6. DMDP7Y5 RU https://pubmed.ncbi.nlm.nih.gov/10075775 DMSGNM1 DI DMSGNM1 DMSGNM1 DN Sideroxylonal C DMSGNM1 MI TTTO43N DMSGNM1 MN Endothelial plasminogen activator inhibitor (SERPINE1) DMSGNM1 MT DTT DMSGNM1 MA Inhibitor DMSGNM1 RN Sideroxylonal C, a new inhibitor of human plasminogen activator inhibitor type-1, from the flowers of Eucalyptus albens. J Nat Prod. 1999 Feb;62(2):324-6. DMSGNM1 RU https://pubmed.ncbi.nlm.nih.gov/10075775 DMB70NK DI DMB70NK DMB70NK DN SIGMOIDIN A DMB70NK MI TTELIN2 DMB70NK MN PTPN1 messenger RNA (PTPN1 mRNA) DMB70NK MT DTT DMB70NK MA Inhibitor DMB70NK RN Isoprenylated flavonoids from the stem bark of Erythrina abyssinica. J Nat Prod. 2007 Jun;70(6):1039-42. DMB70NK RU https://pubmed.ncbi.nlm.nih.gov/17489632 DMVH5WK DI DMVH5WK DMVH5WK DN SIGMOIDIN B DMVH5WK MI TTELIN2 DMVH5WK MN PTPN1 messenger RNA (PTPN1 mRNA) DMVH5WK MT DTT DMVH5WK MA Inhibitor DMVH5WK RN Isoprenylated flavonoids from the stem bark of Erythrina abyssinica. J Nat Prod. 2007 Jun;70(6):1039-42. DMVH5WK RU https://pubmed.ncbi.nlm.nih.gov/17489632 DM8E62L DI DM8E62L DM8E62L DN Sigmoidin F DM8E62L MI TTELIN2 DM8E62L MN PTPN1 messenger RNA (PTPN1 mRNA) DM8E62L MT DTT DM8E62L MA Inhibitor DM8E62L RN Isoprenylated flavonoids from the stem bark of Erythrina abyssinica. J Nat Prod. 2007 Jun;70(6):1039-42. DM8E62L RU https://pubmed.ncbi.nlm.nih.gov/17489632 DM4VDMP DI DM4VDMP DM4VDMP DN silahexocyclium DM4VDMP MI TTOXS3C DM4VDMP MN Muscarinic acetylcholine receptor (CHRM) DM4VDMP MT DTT DM4VDMP MA Antagonist DM4VDMP RN Antagonist binding properties of five cloned muscarinic receptors expressed in CHO-K1 cells. Mol Pharmacol. 1989 Apr;35(4):469-76. DM4VDMP RU https://pubmed.ncbi.nlm.nih.gov/2704370 DM4VDMP DI DM4VDMP DM4VDMP DN silahexocyclium DM4VDMP MI TTQ13Z5 DM4VDMP MN Muscarinic acetylcholine receptor M3 (CHRM3) DM4VDMP MT DTT DM4VDMP MA Antagonist DM4VDMP RN Antagonist binding properties of five cloned muscarinic receptors expressed in CHO-K1 cells. Mol Pharmacol. 1989 Apr;35(4):469-76. DM4VDMP RU https://pubmed.ncbi.nlm.nih.gov/2704370 DM5ZILV DI DM5ZILV DM5ZILV DN Silicon-modified indomethacin DM5ZILV MI TTVKILB DM5ZILV MN Prostaglandin G/H synthase 2 (COX-2) DM5ZILV MT DTT DM5ZILV MA Inhibitor DM5ZILV RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1376). DM5ZILV RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1376 DMQIBZD DI DMQIBZD DMQIBZD DN Silmitasertib DMQIBZD MI TTDT8RP DMQIBZD MN HUMAN casein kinase II (CSK2) DMQIBZD MT DTT DMQIBZD MA Inhibitor DMQIBZD RN News report, company report or official report of Senhwa Biosciences, Inc. Senhwa Biosciences Silmitasertib Named as Potential COVID-19 Therapy. 2020 March 31. DMQIBZD RU https://www.ptcommunity.com/wire/senhwa-biosciences-silmitasertib-named-potential-covid-19-therapy DM5JKNF DI DM5JKNF DM5JKNF DN Silvestrol DM5JKNF MI TTIGYVZ DM5JKNF MN HUMAN eukaryotic initiation factor-4A (eIF4A) DM5JKNF MT DTT DM5JKNF MA Inhibitor DM5JKNF RN Broad-spectrum antiviral activity of the eIF4A inhibitor silvestrol against corona- and picornaviruses. Antiviral Res. 2018 Feb;150:123-129. DM5JKNF RU https://pubmed.ncbi.nlm.nih.gov/29258862 DMS7EHF DI DMS7EHF DMS7EHF DN Silvestrol DMS7EHF MI DTUGYRD DMS7EHF MN P-glycoprotein 1 (ABCB1) DMS7EHF MT DTP DMS7EHF MA Substrate DMS7EHF RN Resistance to the translation initiation inhibitor silvestrol is mediated by ABCB1/P-glycoprotein overexpression in acute lymphoblastic leukemia cells. AAPS J. 2011 Sep;13(3):357-64. DMS7EHF RU https://doi.org/10.1208/s12248-011-9276-7 DM3LDFB DI DM3LDFB DM3LDFB DN Simoctocog alfa DM3LDFB MI TT1290U DM3LDFB MN Coagulation factor VIII (F8) DM3LDFB MT DTT DM3LDFB MA Modulator DM3LDFB RN A new recombinant factor VIII: from genetics to clinical use DM3LDFB RU https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4517516 DMNWM8H DI DMNWM8H DMNWM8H DN Sinefungin DMNWM8H MI TTFHEWL DMNWM8H MN Streptomyces RNA methyltransferase (Stre-myc carB) DMNWM8H MT DTT DMNWM8H MA Inhibitor DMNWM8H RN The effect of sinefungin and synthetic analogues on RNA and DNA methyltransferases from Streptomyces. J Antibiot (Tokyo). 1991 Oct;44(10):1141-7. DMNWM8H RU https://pubmed.ncbi.nlm.nih.gov/1720117 DM1NXFL DI DM1NXFL DM1NXFL DN S-isopentyl 3-methylbutane-1-sulfinothioate DM1NXFL MI TT2SUAQ DM1NXFL MN Cysteine protease (CYP) DM1NXFL MT DTT DM1NXFL MA Inhibitor DM1NXFL RN Allicin and derivates are cysteine protease inhibitors with antiparasitic activity. Bioorg Med Chem Lett. 2010 Sep 15;20(18):5541-3. DM1NXFL RU https://pubmed.ncbi.nlm.nih.gov/20692829 DMZ30AM DI DMZ30AM DMZ30AM DN S-Isopropyl-Isothiourea DMZ30AM MI TTCM4B3 DMZ30AM MN Nitric-oxide synthase endothelial (NOS3) DMZ30AM MT DTT DMZ30AM MA Inhibitor DMZ30AM RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMZ30AM RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMCMIUG DI DMCMIUG DMCMIUG DN SITS DMCMIUG MI TTOJI4S DMCMIUG MN Calcium-dependent chloride channel anoctamin (ANO) DMCMIUG MT DTT DMCMIUG MA Blocker (channel blocker) DMCMIUG RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 708). DMCMIUG RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=708 DMCMIUG DI DMCMIUG DMCMIUG DN SITS DMCMIUG MI TTST1AJ DMCMIUG MN Chloride channel protein 7 (ClC-7) DMCMIUG MT DTT DMCMIUG MA Blocker (channel blocker) DMCMIUG RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 709). DMCMIUG RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=709 DMEQBU2 DI DMEQBU2 DMEQBU2 DN SJ-8002 DMEQBU2 MI TTPF2QI DMEQBU2 MN Caspase-3 (CASP3) DMEQBU2 MT DTT DMEQBU2 MA Inhibitor DMEQBU2 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1619). DMEQBU2 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1619 DMU1P3T DI DMU1P3T DMU1P3T DN SK&F 107649 DMU1P3T MI TT2J34L DMU1P3T MN Arachidonate 5-lipoxygenase (5-LOX) DMU1P3T MT DTT DMU1P3T MA Inhibitor DMU1P3T RN Selective inhibition of 5-lipoxygenase attenuates glomerulonephritis in the rat. Kidney Int. 1994 May;45(5):1301-10. DMU1P3T RU https://pubmed.ncbi.nlm.nih.gov/8072241 DMYRKEJ DI DMYRKEJ DMYRKEJ DN SK&F-105854 DMYRKEJ MI TTNGILX DMYRKEJ MN Adrenergic receptor alpha-1A (ADRA1A) DMYRKEJ MT DTT DMYRKEJ MA Inhibitor DMYRKEJ RN Pharmacophore identification of alpha(1A)-adrenoceptor antagonists. Bioorg Med Chem Lett. 2005 Feb 1;15(3):657-64. DMYRKEJ RU https://pubmed.ncbi.nlm.nih.gov/15664832 DMYRKEJ DI DMYRKEJ DMYRKEJ DN SK&F-105854 DMYRKEJ MI TTBRKXS DMYRKEJ MN Adrenergic receptor alpha-1B (ADRA1B) DMYRKEJ MT DTT DMYRKEJ MA Inhibitor DMYRKEJ RN Alpha- and beta-adrenoceptors: from the gene to the clinic. 2. Structure-activity relationships and therapeutic applications. J Med Chem. 1995 Sep 15;38(19):3681-716. DMYRKEJ RU https://pubmed.ncbi.nlm.nih.gov/7562902 DMYRKEJ DI DMYRKEJ DMYRKEJ DN SK&F-105854 DMYRKEJ MI TT34BHT DMYRKEJ MN Adrenergic receptor alpha-1D (ADRA1D) DMYRKEJ MT DTT DMYRKEJ MA Inhibitor DMYRKEJ RN Alpha- and beta-adrenoceptors: from the gene to the clinic. 2. Structure-activity relationships and therapeutic applications. J Med Chem. 1995 Sep 15;38(19):3681-716. DMYRKEJ RU https://pubmed.ncbi.nlm.nih.gov/7562902 DMHETY7 DI DMHETY7 DMHETY7 DN SK&F-106686 DMHETY7 MI TTNGILX DMHETY7 MN Adrenergic receptor alpha-1A (ADRA1A) DMHETY7 MT DTT DMHETY7 MA Inhibitor DMHETY7 RN Alpha- and beta-adrenoceptors: from the gene to the clinic. 2. Structure-activity relationships and therapeutic applications. J Med Chem. 1995 Sep 15;38(19):3681-716. DMHETY7 RU https://pubmed.ncbi.nlm.nih.gov/7562902 DMHETY7 DI DMHETY7 DMHETY7 DN SK&F-106686 DMHETY7 MI TTBRKXS DMHETY7 MN Adrenergic receptor alpha-1B (ADRA1B) DMHETY7 MT DTT DMHETY7 MA Inhibitor DMHETY7 RN Alpha- and beta-adrenoceptors: from the gene to the clinic. 2. Structure-activity relationships and therapeutic applications. J Med Chem. 1995 Sep 15;38(19):3681-716. DMHETY7 RU https://pubmed.ncbi.nlm.nih.gov/7562902 DMHETY7 DI DMHETY7 DMHETY7 DN SK&F-106686 DMHETY7 MI TT34BHT DMHETY7 MN Adrenergic receptor alpha-1D (ADRA1D) DMHETY7 MT DTT DMHETY7 MA Inhibitor DMHETY7 RN Alpha- and beta-adrenoceptors: from the gene to the clinic. 2. Structure-activity relationships and therapeutic applications. J Med Chem. 1995 Sep 15;38(19):3681-716. DMHETY7 RU https://pubmed.ncbi.nlm.nih.gov/7562902 DM2KFQ5 DI DM2KFQ5 DM2KFQ5 DN SK&F-29661 DM2KFQ5 MI TTWG9A4 DM2KFQ5 MN Adrenergic receptor alpha-2A (ADRA2A) DM2KFQ5 MT DTT DM2KFQ5 MA Inhibitor DM2KFQ5 RN Exploring the active site of phenylethanolamine N-methyltransferase with 3-hydroxyethyl- and 3-hydroxypropyl-7-substituted-1,2,3,4-tetrahydroisoqui... Bioorg Med Chem Lett. 2005 Feb 15;15(4):1143-7. DM2KFQ5 RU https://pubmed.ncbi.nlm.nih.gov/15686930 DM60Y3Q DI DM60Y3Q DM60Y3Q DN SK&F-64139 DM60Y3Q MI TTWG9A4 DM60Y3Q MN Adrenergic receptor alpha-2A (ADRA2A) DM60Y3Q MT DTT DM60Y3Q MA Inhibitor DM60Y3Q RN Comparison of the binding of 3-fluoromethyl-7-sulfonyl-1,2,3,4-tetrahydroisoquinolines with their isosteric sulfonamides to the active site of phen... J Med Chem. 2006 Sep 7;49(18):5424-33. DM60Y3Q RU https://pubmed.ncbi.nlm.nih.gov/16942016 DM60Y3Q DI DM60Y3Q DM60Y3Q DN SK&F-64139 DM60Y3Q MI TTWM4TY DM60Y3Q MN Adrenergic receptor alpha-2B (ADRA2B) DM60Y3Q MT DTT DM60Y3Q MA Inhibitor DM60Y3Q RN Comparison of the binding of 3-fluoromethyl-7-sulfonyl-1,2,3,4-tetrahydroisoquinolines with their isosteric sulfonamides to the active site of phen... J Med Chem. 2006 Sep 7;49(18):5424-33. DM60Y3Q RU https://pubmed.ncbi.nlm.nih.gov/16942016 DM60Y3Q DI DM60Y3Q DM60Y3Q DN SK&F-64139 DM60Y3Q MI TT2NUT5 DM60Y3Q MN Adrenergic receptor alpha-2C (ADRA2C) DM60Y3Q MT DTT DM60Y3Q MA Inhibitor DM60Y3Q RN Comparison of the binding of 3-fluoromethyl-7-sulfonyl-1,2,3,4-tetrahydroisoquinolines with their isosteric sulfonamides to the active site of phen... J Med Chem. 2006 Sep 7;49(18):5424-33. DM60Y3Q RU https://pubmed.ncbi.nlm.nih.gov/16942016 DM4RHEZ DI DM4RHEZ DM4RHEZ DN SK&F-86466 DM4RHEZ MI TTNGILX DM4RHEZ MN Adrenergic receptor alpha-1A (ADRA1A) DM4RHEZ MT DTT DM4RHEZ MA Inhibitor DM4RHEZ RN Alpha- and beta-adrenoceptors: from the gene to the clinic. 2. Structure-activity relationships and therapeutic applications. J Med Chem. 1995 Sep 15;38(19):3681-716. DM4RHEZ RU https://pubmed.ncbi.nlm.nih.gov/7562902 DM4RHEZ DI DM4RHEZ DM4RHEZ DN SK&F-86466 DM4RHEZ MI TTBRKXS DM4RHEZ MN Adrenergic receptor alpha-1B (ADRA1B) DM4RHEZ MT DTT DM4RHEZ MA Inhibitor DM4RHEZ RN Alpha- and beta-adrenoceptors: from the gene to the clinic. 2. Structure-activity relationships and therapeutic applications. J Med Chem. 1995 Sep 15;38(19):3681-716. DM4RHEZ RU https://pubmed.ncbi.nlm.nih.gov/7562902 DM4RHEZ DI DM4RHEZ DM4RHEZ DN SK&F-86466 DM4RHEZ MI TT34BHT DM4RHEZ MN Adrenergic receptor alpha-1D (ADRA1D) DM4RHEZ MT DTT DM4RHEZ MA Inhibitor DM4RHEZ RN Alpha- and beta-adrenoceptors: from the gene to the clinic. 2. Structure-activity relationships and therapeutic applications. J Med Chem. 1995 Sep 15;38(19):3681-716. DM4RHEZ RU https://pubmed.ncbi.nlm.nih.gov/7562902 DM3SUKX DI DM3SUKX DM3SUKX DN SK&F-89626 DM3SUKX MI TTZFYLI DM3SUKX MN Dopamine D1 receptor (D1R) DM3SUKX MT DTT DM3SUKX MA Inhibitor DM3SUKX RN trans-10,11-dihydroxy-5,6,6a,7,8,12b-hexahydrobenzo[a]phenanthridine: a highly potent selective dopamine D1 full agonist. J Med Chem. 1990 Jun;33(6):1756-64. DM3SUKX RU https://pubmed.ncbi.nlm.nih.gov/1971308 DM3SUKX DI DM3SUKX DM3SUKX DN SK&F-89626 DM3SUKX MI TTEX248 DM3SUKX MN Dopamine D2 receptor (D2R) DM3SUKX MT DTT DM3SUKX MA Inhibitor DM3SUKX RN trans-10,11-dihydroxy-5,6,6a,7,8,12b-hexahydrobenzo[a]phenanthridine: a highly potent selective dopamine D1 full agonist. J Med Chem. 1990 Jun;33(6):1756-64. DM3SUKX RU https://pubmed.ncbi.nlm.nih.gov/1971308 DMMYX7C DI DMMYX7C DMMYX7C DN SK1-I DMMYX7C MI TTOHFIY DMMYX7C MN Sphingosine kinase 1 (SPHK1) DMMYX7C MT DTT DMMYX7C MA Inhibitor DMMYX7C RN A selective sphingosine kinase 1 inhibitor integrates multiple molecular therapeutic targets in human leukemia. Blood. 2008 Aug 15;112(4):1382-91. DMMYX7C RU https://pubmed.ncbi.nlm.nih.gov/18511810 DM73SC6 DI DM73SC6 DM73SC6 DN SK509 DM73SC6 MI TTJVCG0 DM73SC6 MN Bacterial Sporulation kinase A (Bact kinA) DM73SC6 MT DTT DM73SC6 MA Inhibitor DM73SC6 RN Histidine kinases as targets for new antimicrobial agents. Bioorg Med Chem. 2002 Apr;10(4):855-67. DM73SC6 RU https://pubmed.ncbi.nlm.nih.gov/11836091 DM73SC6 DI DM73SC6 DM73SC6 DN SK509 DM73SC6 MI TTCIHJA DM73SC6 MN Coagulation factor Xa (F10) DM73SC6 MT DTT DM73SC6 MA Inhibitor DM73SC6 RN The design and synthesis of noncovalent factor Xa inhibitors. Curr Top Med Chem. 2001 Jun;1(2):137-49. DM73SC6 RU https://pubmed.ncbi.nlm.nih.gov/11899249 DMK1OP2 DI DMK1OP2 DMK1OP2 DN SK549 DMK1OP2 MI TTCIHJA DMK1OP2 MN Coagulation factor Xa (F10) DMK1OP2 MT DTT DMK1OP2 MA Inhibitor DMK1OP2 RN Design and synthesis of isoxazoline derivatives as factor Xa inhibitors. 2. J Med Chem. 1999 Jul 29;42(15):2760-73. DMK1OP2 RU https://pubmed.ncbi.nlm.nih.gov/10425087 DMUTBZ8 DI DMUTBZ8 DMUTBZ8 DN SK554 DMUTBZ8 MI TTCIHJA DMUTBZ8 MN Coagulation factor Xa (F10) DMUTBZ8 MT DTT DMUTBZ8 MA Inhibitor DMUTBZ8 RN Novel approaches to the treatment of thrombosis. Trends Pharmacol Sci. 2002 Jan;23(1):25-32. DMUTBZ8 RU https://pubmed.ncbi.nlm.nih.gov/11804648 DMM32CF DI DMM32CF DMM32CF DN SK-683 DMM32CF MI TT6R7JZ DMM32CF MN Histone deacetylase 1 (HDAC1) DMM32CF MT DTT DMM32CF MA Inhibitor DMM32CF RN On the function of the 14 A long internal cavity of histone deacetylase-like protein: implications for the design of histone deacetylase inhibitors. J Med Chem. 2004 Jun 17;47(13):3409-17. DMM32CF RU https://pubmed.ncbi.nlm.nih.gov/15189037 DMBL7YN DI DMBL7YN DMBL7YN DN SKA-121 DMBL7YN MI TT7M9I6 DMBL7YN MN Calcium-activated potassium channel KCa3.1 (KCNN4) DMBL7YN MT DTT DMBL7YN MA Activator DMBL7YN RN New positive Ca2+-activated K+ channel gating modulators with selectivity for KCa3.1. Mol Pharmacol. 2014 Sep;86(3):342-57. DMBL7YN RU https://pubmed.ncbi.nlm.nih.gov/24958817 DMX34F1 DI DMX34F1 DMX34F1 DN SKA-31 DMX34F1 MI TT7M9I6 DMX34F1 MN Calcium-activated potassium channel KCa3.1 (KCNN4) DMX34F1 MT DTT DMX34F1 MA Activator DMX34F1 RN Naphtho[1,2-d]thiazol-2-ylamine (SKA-31), a new activator of KCa2 and KCa3.1 potassium channels, potentiates the endothelium-derived hyperpolarizing factor response and lowers blood pressure. Mol Pharmacol. 2009 Feb;75(2):281-95. DMX34F1 RU https://pubmed.ncbi.nlm.nih.gov/18955585 DMWODHR DI DMWODHR DMWODHR DN SKF 89748 DMWODHR MI TT2NUT5 DMWODHR MN Adrenergic receptor alpha-2C (ADRA2C) DMWODHR MT DTT DMWODHR MA Agonist DMWODHR RN Selectivity of agonists for cloned alpha 1-adrenergic receptor subtypes. Mol Pharmacol. 1994 Nov;46(5):929-36. DMWODHR RU https://pubmed.ncbi.nlm.nih.gov/7969082 DMQ6YXF DI DMQ6YXF DMQ6YXF DN SKF-75670 DMQ6YXF MI TTZFYLI DMQ6YXF MN Dopamine D1 receptor (D1R) DMQ6YXF MT DTT DMQ6YXF MA Agonist DMQ6YXF RN Dopamine receptor agonists: selectivity and dopamine D1 receptor efficacy. Eur J Pharmacol. 1990 Jun 12;188(6):335-47. DMQ6YXF RU https://pubmed.ncbi.nlm.nih.gov/1973652 DMCMQH8 DI DMCMQH8 DMCMQH8 DN SKF-83556 DMCMQH8 MI TTZFYLI DMCMQH8 MN Dopamine D1 receptor (D1R) DMCMQH8 MT DTT DMCMQH8 MA Antagonist DMCMQH8 RN Cloning of the gene for a human dopamine D5 receptor with higher affinity for dopamine than D1. Nature. 1991 Apr 18;350(6319):614-9. DMCMQH8 RU https://pubmed.ncbi.nlm.nih.gov/1826762 DMCMQH8 DI DMCMQH8 DMCMQH8 DN SKF-83556 DMCMQH8 MI TTS2PH3 DMCMQH8 MN Dopamine D5 receptor (D5R) DMCMQH8 MT DTT DMCMQH8 MA Antagonist DMCMQH8 RN Cloning of the gene for a human dopamine D5 receptor with higher affinity for dopamine than D1. Nature. 1991 Apr 18;350(6319):614-9. DMCMQH8 RU https://pubmed.ncbi.nlm.nih.gov/1826762 DMWC6RU DI DMWC6RU DMWC6RU DN SKF-83959 DMWC6RU MI TTZFYLI DMWC6RU MN Dopamine D1 receptor (D1R) DMWC6RU MT DTT DMWC6RU MA Agonist DMWC6RU RN Identification of G protein-biased agonists that fail to recruit beta-arrestin or promote internalization of the D1 dopamine receptor. ACS Chem Neurosci. 2015 Apr 15;6(4):681-92. DMWC6RU RU https://pubmed.ncbi.nlm.nih.gov/25660762 DMNUQ9P DI DMNUQ9P DMNUQ9P DN SKF-89124A DMNUQ9P MI TTEX248 DMNUQ9P MN Dopamine D2 receptor (D2R) DMNUQ9P MT DTT DMNUQ9P MA Inhibitor DMNUQ9P RN Synthesis and evaluation of non-catechol D-1 and D-2 dopamine receptor agonists: benzimidazol-2-one, benzoxazol-2-one, and the highly potent benzot... J Med Chem. 1987 Jul;30(7):1166-76. DMNUQ9P RU https://pubmed.ncbi.nlm.nih.gov/2955118 DM0WNHQ DI DM0WNHQ DM0WNHQ DN SKF89976A DM0WNHQ MI TTPRKM0 DM0WNHQ MN GABA transporter GAT-1 (SLC6A1) DM0WNHQ MT DTT DM0WNHQ MA Inhibitor DM0WNHQ RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 929). DM0WNHQ RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=929 DMJL6HX DI DMJL6HX DMJL6HX DN SKI-2852 DMJL6HX MI TTN7BL9 DMJL6HX MN Corticosteroid 11-beta-dehydrogenase 1 (HSD11B1) DMJL6HX MT DTT DMJL6HX MA Inhibitor DMJL6HX RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2763). DMJL6HX RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2763 DMXS9V8 DI DMXS9V8 DMXS9V8 DN SKL-18287 DMXS9V8 MI TTVIMDE DMXS9V8 MN Glucagon-like peptide 1 receptor (GLP1R) DMXS9V8 MT DTT DMXS9V8 MA Modulator DMXS9V8 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 249). DMXS9V8 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=249 DM5T4Y1 DI DM5T4Y1 DM5T4Y1 DN SKL-19014 DM5T4Y1 MI TTDLNGZ DM5T4Y1 MN Glucokinase (GCK) DM5T4Y1 MT DTT DM5T4Y1 MA Activator DM5T4Y1 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2798). DM5T4Y1 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2798 DMUVAFO DI DMUVAFO DMUVAFO DN SKLB-010 DMUVAFO MI TTF10I9 DMUVAFO MN Nitric-oxide synthase inducible (NOS2) DMUVAFO MT DTT DMUVAFO MA Modulator DMUVAFO RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1250). DMUVAFO RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1250 DM4X2GH DI DM4X2GH DM4X2GH DN SKL-PD DM4X2GH MI TTGP7BY DM4X2GH MN Monoamine oxidase type B (MAO-B) DM4X2GH MT DTT DM4X2GH MA Inhibitor DM4X2GH RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2490). DM4X2GH RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2490 DMGQ9Z5 DI DMGQ9Z5 DMGQ9Z5 DN SKS-927 DMGQ9Z5 MI TT6PKBN DMGQ9Z5 MN Proto-oncogene c-Src (SRC) DMGQ9Z5 MT DTT DMGQ9Z5 MA Inhibitor DMGQ9Z5 RN Inhibition of Src kinase activity by 7-ethynyl-4-phenylamino-3-quinolinecarbonitriles: identification of SKS-927. Bioorg Med Chem Lett. 2007 Mar 1;17(5):1358-61. DMGQ9Z5 RU https://pubmed.ncbi.nlm.nih.gov/17188862 DMEIZ20 DI DMEIZ20 DMEIZ20 DN SL125 DMEIZ20 MI TTIQUX7 DMEIZ20 MN Steroid 11-beta-hydroxylase (CYP11B1) DMEIZ20 MT DTT DMEIZ20 MA Inhibitor DMEIZ20 RN Reduction of cell proliferation induced by PD166866: an inhibitor of the basic fibroblast growth factor. J Exp Clin Cancer Res. 2007 Sep;26(3):405-9. DMEIZ20 RU https://pubmed.ncbi.nlm.nih.gov/17987803 DM0UE28 DI DM0UE28 DM0UE28 DN SL-3111 DM0UE28 MI TTKWM86 DM0UE28 MN Opioid receptor mu (MOP) DM0UE28 MT DTT DM0UE28 MA Inhibitor DM0UE28 RN Exploring the structure-activity relationships of [1-(4-tert-butyl-3'-hydroxy)benzhydryl-4-benzylpiperazine] (SL-3111), a high-affinity and selecti... J Med Chem. 1999 Dec 30;42(26):5359-68. DM0UE28 RU https://pubmed.ncbi.nlm.nih.gov/10639279 DMYJV4I DI DMYJV4I DMYJV4I DN SL-327 DMYJV4I MI TTROQ37 DMYJV4I MN MAPK/ERK kinase kinase (MAP3K) DMYJV4I MT DTT DMYJV4I MA Inhibitor DMYJV4I RN A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases. Proc Natl Acad Sci U S A. 2007 Dec 18;104(51):20523-8. DMYJV4I RU https://pubmed.ncbi.nlm.nih.gov/18077363 DM3I2US DI DM3I2US DM3I2US DN SL422 DM3I2US MI TTHY57M DM3I2US MN Matrix metalloproteinase-13 (MMP-13) DM3I2US MT DTT DM3I2US MA Inhibitor DM3I2US RN Design, synthesis, and structure-activity relationships of macrocyclic hydroxamic acids that inhibit tumor necrosis factor alpha release in vitro and in vivo. J Med Chem. 2001 Aug 2;44(16):2636-60. DM3I2US RU https://pubmed.ncbi.nlm.nih.gov/11472217 DM3I2US DI DM3I2US DM3I2US DN SL422 DM3I2US MI TTNSTO3 DM3I2US MN Matrix metalloproteinase-15 (MMP-15) DM3I2US MT DTT DM3I2US MA Inhibitor DM3I2US RN Design, synthesis, and structure-activity relationships of macrocyclic hydroxamic acids that inhibit tumor necrosis factor alpha release in vitro and in vivo. J Med Chem. 2001 Aug 2;44(16):2636-60. DM3I2US RU https://pubmed.ncbi.nlm.nih.gov/11472217 DM3I2US DI DM3I2US DM3I2US DN SL422 DM3I2US MI TTNP4CU DM3I2US MN Matrix metalloproteinase-16 (MMP-16) DM3I2US MT DTT DM3I2US MA Inhibitor DM3I2US RN Design, synthesis, and structure-activity relationships of macrocyclic hydroxamic acids that inhibit tumor necrosis factor alpha release in vitro and in vivo. J Med Chem. 2001 Aug 2;44(16):2636-60. DM3I2US RU https://pubmed.ncbi.nlm.nih.gov/11472217 DM3I2US DI DM3I2US DM3I2US DN SL422 DM3I2US MI TTMTWOS DM3I2US MN Matrix metalloproteinase-7 (MMP-7) DM3I2US MT DTT DM3I2US MA Inhibitor DM3I2US RN Design, synthesis, and structure-activity relationships of macrocyclic hydroxamic acids that inhibit tumor necrosis factor alpha release in vitro and in vivo. J Med Chem. 2001 Aug 2;44(16):2636-60. DM3I2US RU https://pubmed.ncbi.nlm.nih.gov/11472217 DM3I2US DI DM3I2US DM3I2US DN SL422 DM3I2US MI TTGA1IV DM3I2US MN Matrix metalloproteinase-8 (MMP-8) DM3I2US MT DTT DM3I2US MA Inhibitor DM3I2US RN Design, synthesis, and structure-activity relationships of macrocyclic hydroxamic acids that inhibit tumor necrosis factor alpha release in vitro and in vivo. J Med Chem. 2001 Aug 2;44(16):2636-60. DM3I2US RU https://pubmed.ncbi.nlm.nih.gov/11472217 DM3I2US DI DM3I2US DM3I2US DN SL422 DM3I2US MI TT6X50U DM3I2US MN Matrix metalloproteinase-9 (MMP-9) DM3I2US MT DTT DM3I2US MA Inhibitor DM3I2US RN Design, synthesis, and structure-activity relationships of macrocyclic hydroxamic acids that inhibit tumor necrosis factor alpha release in vitro and in vivo. J Med Chem. 2001 Aug 2;44(16):2636-60. DM3I2US RU https://pubmed.ncbi.nlm.nih.gov/11472217 DM3I2US DI DM3I2US DM3I2US DN SL422 DM3I2US MI TT6AZXG DM3I2US MN TNF alpha converting enzyme (ADAM17) DM3I2US MT DTT DM3I2US MA Inhibitor DM3I2US RN Design, synthesis, and structure-activity relationships of macrocyclic hydroxamic acids that inhibit tumor necrosis factor alpha release in vitro and in vivo. J Med Chem. 2001 Aug 2;44(16):2636-60. DM3I2US RU https://pubmed.ncbi.nlm.nih.gov/11472217 DMEBPCO DI DMEBPCO DMEBPCO DN SLG DMEBPCO MI TTRBT3W DMEBPCO MN Short transient receptor potential channel 6 (TRPC6) DMEBPCO MT DTT DMEBPCO MA Activator DMEBPCO RN Direct activation of human TRPC6 and TRPC3 channels by diacylglycerol. Nature. 1999 Jan 21;397(6716):259-63. DMEBPCO RU https://pubmed.ncbi.nlm.nih.gov/9930701 DMBD6TC DI DMBD6TC DMBD6TC DN slotoxin DMBD6TC MI TT1AQ50 DMBD6TC MN Charybdotoxin receptor beta-4 (BKbeta4) DMBD6TC MT DTT DMBD6TC MA Blocker (channel blocker) DMBD6TC RN Slotoxin, alphaKTx1.11, a new scorpion peptide blocker of MaxiK channels that differentiates between alpha and alpha+beta (beta1 or beta4) complexes. FEBS Lett. 2001 Sep 21;505(3):369-73. DMBD6TC RU https://pubmed.ncbi.nlm.nih.gov/11576530 DMPETL7 DI DMPETL7 DMPETL7 DN SLV-314 DMPETL7 MI TTEX248 DMPETL7 MN Dopamine D2 receptor (D2R) DMPETL7 MT DTT DMPETL7 MA Inhibitor DMPETL7 RN Synthesis, structure-activity relationships, and biological properties of 1-heteroaryl-4-[omega-(1H-indol-3-yl)alkyl]piperazines, novel potential a... J Med Chem. 2005 Nov 3;48(22):6855-69. DMPETL7 RU https://pubmed.ncbi.nlm.nih.gov/16250644 DM7MSGK DI DM7MSGK DM7MSGK DN SM 21 DM7MSGK MI TT9NXW4 DM7MSGK MN Sigma intracellular receptor 2 (TMEM97) DM7MSGK MT DTT DM7MSGK MA Antagonist DM7MSGK RN The analgesic tropane analogue (+/-)-SM 21 has a high affinity for sigma2 receptors. Life Sci. 1999;64(10):PL131-7. DM7MSGK RU https://pubmed.ncbi.nlm.nih.gov/10096443 DMC7YQE DI DMC7YQE DMC7YQE DN SM-122 DMC7YQE MI TTAIWZN DMC7YQE MN Apoptosis-2 messenger RNA (BIRC3 mRNA) DMC7YQE MT DTT DMC7YQE MA Inhibitor DMC7YQE RN Nonpeptidic and potent small-molecule inhibitors of cIAP-1/2 and XIAP proteins. J Med Chem. 2010 Sep 9;53(17):6361-7. DMC7YQE RU https://pubmed.ncbi.nlm.nih.gov/20684551 DMC7YQE DI DMC7YQE DMC7YQE DN SM-122 DMC7YQE MI TTK3WBU DMC7YQE MN XIAP messenger RNA (XIAP mRNA) DMC7YQE MT DTT DMC7YQE MA Inhibitor DMC7YQE RN Nonpeptidic and potent small-molecule inhibitors of cIAP-1/2 and XIAP proteins. J Med Chem. 2010 Sep 9;53(17):6361-7. DMC7YQE RU https://pubmed.ncbi.nlm.nih.gov/20684551 DMKZVEQ DI DMKZVEQ DMKZVEQ DN SM-130,686 DMKZVEQ MI TTWDC17 DMKZVEQ MN Growth hormone secretagogue receptor 1 (GHSR) DMKZVEQ MT DTT DMKZVEQ MA Agonist DMKZVEQ RN Oxindole derivatives as orally active potent growth hormone secretagogues. J Med Chem. 2001 Dec 20;44(26):4641-9. DMKZVEQ RU https://pubmed.ncbi.nlm.nih.gov/11741481 DMP8VO6 DI DMP8VO6 DMP8VO6 DN SM-131 DMP8VO6 MI TTAIWZN DMP8VO6 MN Apoptosis-2 messenger RNA (BIRC3 mRNA) DMP8VO6 MT DTT DMP8VO6 MA Inhibitor DMP8VO6 RN Design, synthesis, and evaluation of tricyclic, conformationally constrained small-molecule mimetics of second mitochondria-derived activator of ca... J Med Chem. 2008 Dec 11;51(23):7352-5. DMP8VO6 RU https://pubmed.ncbi.nlm.nih.gov/19012392 DMP8VO6 DI DMP8VO6 DMP8VO6 DN SM-131 DMP8VO6 MI TTK3WBU DMP8VO6 MN XIAP messenger RNA (XIAP mRNA) DMP8VO6 MT DTT DMP8VO6 MA Inhibitor DMP8VO6 RN Design, synthesis, and evaluation of tricyclic, conformationally constrained small-molecule mimetics of second mitochondria-derived activator of ca... J Med Chem. 2008 Dec 11;51(23):7352-5. DMP8VO6 RU https://pubmed.ncbi.nlm.nih.gov/19012392 DMOSTP9 DI DMOSTP9 DMOSTP9 DN SM-337 DMOSTP9 MI TTAIWZN DMOSTP9 MN Apoptosis-2 messenger RNA (BIRC3 mRNA) DMOSTP9 MT DTT DMOSTP9 MA Inhibitor DMOSTP9 RN Nonpeptidic and potent small-molecule inhibitors of cIAP-1/2 and XIAP proteins. J Med Chem. 2010 Sep 9;53(17):6361-7. DMOSTP9 RU https://pubmed.ncbi.nlm.nih.gov/20684551 DMOSTP9 DI DMOSTP9 DMOSTP9 DN SM-337 DMOSTP9 MI TTK3WBU DMOSTP9 MN XIAP messenger RNA (XIAP mRNA) DMOSTP9 MT DTT DMOSTP9 MA Inhibitor DMOSTP9 RN Nonpeptidic and potent small-molecule inhibitors of cIAP-1/2 and XIAP proteins. J Med Chem. 2010 Sep 9;53(17):6361-7. DMOSTP9 RU https://pubmed.ncbi.nlm.nih.gov/20684551 DMWJ70Q DI DMWJ70Q DMWJ70Q DN Small molecule 34 DMWJ70Q MI TTQBR95 DMWJ70Q MN Stress-activated protein kinase 2a (p38 alpha) DMWJ70Q MT DTT DMWJ70Q MA Inhibitor DMWJ70Q RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMWJ70Q RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMGJTL3 DI DMGJTL3 DMGJTL3 DN SMaRT FVIII DMGJTL3 MI TT1290U DMGJTL3 MN Coagulation factor VIII (F8) DMGJTL3 MT DTT DMGJTL3 MA Modulator DMGJTL3 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2607). DMGJTL3 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2607 DMZC2BT DI DMZC2BT DMZC2BT DN SMEATHXANTHONE A DMZC2BT MI TT50QJ3 DMZC2BT MN Influenza Neuraminidase (Influ NA) DMZC2BT MT DTT DMZC2BT MA Inhibitor DMZC2BT RN Xanthones with neuraminidase inhibitory activity from the seedcases of Garcinia mangostana. Bioorg Med Chem. 2010 Sep 1;18(17):6258-64. DMZC2BT RU https://pubmed.ncbi.nlm.nih.gov/20696581 DM79QC2 DI DM79QC2 DM79QC2 DN S-methyl 4-methyl-4-morpholinopent-2-ynethioate DM79QC2 MI TTB6UM0 DM79QC2 MN Fatty aldehyde dehydrogenase (ALDH3A2) DM79QC2 MT DTT DM79QC2 MA Inhibitor DM79QC2 RN Aldehyde dehydrogenase inhibitors: alpha,beta-acetylenic N-substituted aminothiolesters are reversible growth inhibitors of normal epithelial but i... Eur J Med Chem. 2008 May;43(5):906-16. DM79QC2 RU https://pubmed.ncbi.nlm.nih.gov/17692435 DMAMRKS DI DMAMRKS DMAMRKS DN S-Methylcysteine DMAMRKS MI TTPT2QI DMAMRKS MN Cathepsin D (CTSD) DMAMRKS MT DTT DMAMRKS MA Inhibitor DMAMRKS RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMAMRKS RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMAMRKS DI DMAMRKS DMAMRKS DN S-Methylcysteine DMAMRKS MI TTJ8DV7 DMAMRKS MN O-6-methylguanine-DNA-alkyltransferase (MGMT) DMAMRKS MT DTT DMAMRKS MA Inhibitor DMAMRKS RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMAMRKS RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMBLWMS DI DMBLWMS DMBLWMS DN SMI-4a DMBLWMS MI TTTN5QW DMBLWMS MN Serine/threonine-protein kinase pim-1 (PIM1) DMBLWMS MT DTT DMBLWMS MA Inhibitor DMBLWMS RN Pim-1 inhibitor SMI-4a suppresses tumor growth in non-small cell lung cancer via PI3K/AKT/mTOR pathway. Onco Targets Ther. 2019 Apr 23;12:3043-3050. DMBLWMS RU https://pubmed.ncbi.nlm.nih.gov/31114247 DMABIX1 DI DMABIX1 DMABIX1 DN SMOi2-17 DMABIX1 MI TT8J1S3 DMABIX1 MN Smoothened homolog (SMO) DMABIX1 MT DTT DMABIX1 MA Antagonist DMABIX1 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 239). DMABIX1 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=239 DMSI95J DI DMSI95J DMSI95J DN SMP-797 DMSI95J MI TTMF541 DMSI95J MN Liver carboxylesterase (CES1) DMSI95J MT DTT DMSI95J MA Modulator DMSI95J RN Company report (Dainippon Sumitomo Pharma) DMSI95J RU http://www.ds-pharma.com/ir/library/presentation/pdf/eir20060314.pdf (A lowering of plasma cholesterol by ACAT inhibition and enhancing LDL receptor activity leads to the direct inhibition of the progress of arteriosclerosis by ACAT inhibition) DMO8G39 DI DMO8G39 DMO8G39 DN S-MTC DMO8G39 MI DEY0TQC DMO8G39 MN Dimethylarginine dimethylaminohydrolase 1 (DDAH1) DMO8G39 MT DME DMO8G39 MA Metabolism DMO8G39 RN Developing dual and specific inhibitors of dimethylarginine dimethylaminohydrolase-1 and nitric oxide synthase: toward a targeted polypharmacology to control nitric oxide. Biochemistry. 2009 Sep 15;48(36):8624-35. DMO8G39 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=19663506 DM9SF48 DI DM9SF48 DM9SF48 DN SMTP-0 DM9SF48 MI TTP86E2 DM9SF48 MN Plasminogen (PLG) DM9SF48 MT DTT DM9SF48 MA Modulator DM9SF48 RN Tranexamic acid in trauma: how should we use it. J Trauma Acute Care Surg. 2013 Jun;74(6):1575-86. DM9SF48 RU https://pubmed.ncbi.nlm.nih.gov/23694890 DMWCSQH DI DMWCSQH DMWCSQH DN SN-1 DMWCSQH MI TT0NLAQ DMWCSQH MN Mucolipin-3 (TRPML3) DMWCSQH MT DTT DMWCSQH MA Activator DMWCSQH RN Small molecule activators of TRPML3. Chem Biol. 2010 Feb 26;17(2):135-48. DMWCSQH RU https://pubmed.ncbi.nlm.nih.gov/20189104 DMA0JZM DI DMA0JZM DMA0JZM DN SN-11 DMA0JZM MI TT27RFC DMA0JZM MN Opioid receptor delta (OPRD1) DMA0JZM MT DTT DMA0JZM MA Inhibitor DMA0JZM RN Design and synthesis of novel delta opioid receptor agonists and their pharmacologies. Bioorg Med Chem Lett. 2009 May 15;19(10):2792-5. DMA0JZM RU https://pubmed.ncbi.nlm.nih.gov/19362480 DMA0JZM DI DMA0JZM DMA0JZM DN SN-11 DMA0JZM MI TTQW87Y DMA0JZM MN Opioid receptor kappa (OPRK1) DMA0JZM MT DTT DMA0JZM MA Inhibitor DMA0JZM RN Design and synthesis of novel delta opioid receptor agonists and their pharmacologies. Bioorg Med Chem Lett. 2009 May 15;19(10):2792-5. DMA0JZM RU https://pubmed.ncbi.nlm.nih.gov/19362480 DMA0JZM DI DMA0JZM DMA0JZM DN SN-11 DMA0JZM MI TTKWM86 DMA0JZM MN Opioid receptor mu (MOP) DMA0JZM MT DTT DMA0JZM MA Inhibitor DMA0JZM RN Design and synthesis of novel delta opioid receptor agonists and their pharmacologies. Bioorg Med Chem Lett. 2009 May 15;19(10):2792-5. DMA0JZM RU https://pubmed.ncbi.nlm.nih.gov/19362480 DMYVIBW DI DMYVIBW DMYVIBW DN SN-2 DMYVIBW MI TT0NLAQ DMYVIBW MN Mucolipin-3 (TRPML3) DMYVIBW MT DTT DMYVIBW MA Activator DMYVIBW RN Small molecule activators of TRPML3. Chem Biol. 2010 Feb 26;17(2):135-48. DMYVIBW RU https://pubmed.ncbi.nlm.nih.gov/20189104 DM6O0PD DI DM6O0PD DM6O0PD DN SN-23 DM6O0PD MI TT27RFC DM6O0PD MN Opioid receptor delta (OPRD1) DM6O0PD MT DTT DM6O0PD MA Inhibitor DM6O0PD RN Design and synthesis of novel delta opioid receptor agonists and their pharmacologies. Bioorg Med Chem Lett. 2009 May 15;19(10):2792-5. DM6O0PD RU https://pubmed.ncbi.nlm.nih.gov/19362480 DM6O0PD DI DM6O0PD DM6O0PD DN SN-23 DM6O0PD MI TTQW87Y DM6O0PD MN Opioid receptor kappa (OPRK1) DM6O0PD MT DTT DM6O0PD MA Inhibitor DM6O0PD RN Design and synthesis of novel delta opioid receptor agonists and their pharmacologies. Bioorg Med Chem Lett. 2009 May 15;19(10):2792-5. DM6O0PD RU https://pubmed.ncbi.nlm.nih.gov/19362480 DM6O0PD DI DM6O0PD DM6O0PD DN SN-23 DM6O0PD MI TTKWM86 DM6O0PD MN Opioid receptor mu (MOP) DM6O0PD MT DTT DM6O0PD MA Inhibitor DM6O0PD RN Design and synthesis of novel delta opioid receptor agonists and their pharmacologies. Bioorg Med Chem Lett. 2009 May 15;19(10):2792-5. DM6O0PD RU https://pubmed.ncbi.nlm.nih.gov/19362480 DMB8TJC DI DMB8TJC DMB8TJC DN SN-28 DMB8TJC MI TT27RFC DMB8TJC MN Opioid receptor delta (OPRD1) DMB8TJC MT DTT DMB8TJC MA Inhibitor DMB8TJC RN Design and synthesis of KNT-127, a -opioid receptor agonist effective by systemic administration. Bioorg Med Chem Lett. 2010 Nov 1;20(21):6302-5. DMB8TJC RU https://pubmed.ncbi.nlm.nih.gov/20850307 DMB8TJC DI DMB8TJC DMB8TJC DN SN-28 DMB8TJC MI TTQW87Y DMB8TJC MN Opioid receptor kappa (OPRK1) DMB8TJC MT DTT DMB8TJC MA Inhibitor DMB8TJC RN Design and synthesis of KNT-127, a -opioid receptor agonist effective by systemic administration. Bioorg Med Chem Lett. 2010 Nov 1;20(21):6302-5. DMB8TJC RU https://pubmed.ncbi.nlm.nih.gov/20850307 DMB8TJC DI DMB8TJC DMB8TJC DN SN-28 DMB8TJC MI TTKWM86 DMB8TJC MN Opioid receptor mu (MOP) DMB8TJC MT DTT DMB8TJC MA Inhibitor DMB8TJC RN Design and synthesis of KNT-127, a -opioid receptor agonist effective by systemic administration. Bioorg Med Chem Lett. 2010 Nov 1;20(21):6302-5. DMB8TJC RU https://pubmed.ncbi.nlm.nih.gov/20850307 DM2UVNB DI DM2UVNB DM2UVNB DN SN-38G DM2UVNB MI DE5Z9QK DM2UVNB MN Beta-glucuronidase (uidA) DM2UVNB MT DME DM2UVNB MA Metabolism DM2UVNB RN Three structurally and functionally distinct beta-glucuronidases from the human gut microbe Bacteroides uniformis. J Biol Chem. 2018 Nov 30;293(48):18559-18573. DM2UVNB RU https://pubmed.ncbi.nlm.nih.gov/30301767 DM2UVNB DI DM2UVNB DM2UVNB DN SN-38G DM2UVNB MI DELQJ5O DM2UVNB MN Beta-glucuronidase (uidA) DM2UVNB MT DME DM2UVNB MA Metabolism DM2UVNB RN Three structurally and functionally distinct beta-glucuronidases from the human gut microbe Bacteroides uniformis. J Biol Chem. 2018 Nov 30;293(48):18559-18573. DM2UVNB RU https://pubmed.ncbi.nlm.nih.gov/30301767 DM2UVNB DI DM2UVNB DM2UVNB DN SN-38G DM2UVNB MI DE2IMU4 DM2UVNB MN Beta-glucuronidase (uidA) DM2UVNB MT DME DM2UVNB MA Metabolism DM2UVNB RN Structure and inhibition of microbiome beta-glucuronidases essential to the alleviation of cancer drug toxicity. Chem Biol. 2015 Sep 17;22(9):1238-49. DM2UVNB RU https://pubmed.ncbi.nlm.nih.gov/26364932 DM2UVNB DI DM2UVNB DM2UVNB DN SN-38G DM2UVNB MI DERFVMW DM2UVNB MN Beta-glucuronidase (uidA) DM2UVNB MT DME DM2UVNB MA Metabolism DM2UVNB RN Structure and inhibition of microbiome beta-glucuronidases essential to the alleviation of cancer drug toxicity. Chem Biol. 2015 Sep 17;22(9):1238-49. DM2UVNB RU https://pubmed.ncbi.nlm.nih.gov/26364932 DM2UVNB DI DM2UVNB DM2UVNB DN SN-38G DM2UVNB MI DE9RA0I DM2UVNB MN Beta-glucuronidase (uidA) DM2UVNB MT DME DM2UVNB MA Metabolism DM2UVNB RN Metabolism of irinotecan and its active metabolite SN-38 by intestinal microflora in rats. Oncol Rep. 2008 Oct;20(4):727-30. DM2UVNB RU https://pubmed.ncbi.nlm.nih.gov/18813810 DMP4IJ6 DI DMP4IJ6 DMP4IJ6 DN SN429 DMP4IJ6 MI TTCIHJA DMP4IJ6 MN Coagulation factor Xa (F10) DMP4IJ6 MT DTT DMP4IJ6 MA Inhibitor DMP4IJ6 RN Pharmacological intervention at disparate sites in the coagulation cascade: comparison of anti-thrombotic efficacy vs bleeding propensity in a rat model of acute arterial thrombosis. J Thromb Thrombolysis. 2002 Oct;14(2):113-21. DMP4IJ6 RU https://pubmed.ncbi.nlm.nih.gov/12714830 DMS1AFL DI DMS1AFL DMS1AFL DN SNAP 398299 DMS1AFL MI TTOPAY7 DMS1AFL MN Galanin receptor (GAL-R) DMS1AFL MT DTT DMS1AFL MA Antagonist DMS1AFL RN Anxiolytic- and antidepressant-like profiles of the galanin-3 receptor (Gal3) antagonists SNAP 37889 and SNAP 398299. Proc Natl Acad Sci U S A. 2005 Nov 29;102(48):17489-94. DMS1AFL RU https://pubmed.ncbi.nlm.nih.gov/16287967 DMEJ5CP DI DMEJ5CP DMEJ5CP DN SNAP-5036 DMEJ5CP MI TTNGILX DMEJ5CP MN Adrenergic receptor alpha-1A (ADRA1A) DMEJ5CP MT DTT DMEJ5CP MA Inhibitor DMEJ5CP RN Pharmacophore identification of alpha(1A)-adrenoceptor antagonists. Bioorg Med Chem Lett. 2005 Feb 1;15(3):657-64. DMEJ5CP RU https://pubmed.ncbi.nlm.nih.gov/15664832 DMFM19S DI DMFM19S DMFM19S DN SNAP-5114 DMFM19S MI TTHVBOC DMFM19S MN Gamma-aminobutyric acid transporter 4 (SLC6A11) DMFM19S MT DTT DMFM19S MA Blocker DMFM19S RN GABA-level increasing and anticonvulsant effects of three different GABA uptake inhibitors. Neuropharmacology. 2000 Sep;39(12):2399-407. DMFM19S RU https://pubmed.ncbi.nlm.nih.gov/10974324 DM2OLGQ DI DM2OLGQ DM2OLGQ DN SNAP-5150 DM2OLGQ MI TTWG9A4 DM2OLGQ MN Adrenergic receptor alpha-2A (ADRA2A) DM2OLGQ MT DTT DM2OLGQ MA Inhibitor DM2OLGQ RN Design and synthesis of novel dihydropyridine alpha-1a antagonists. Bioorg Med Chem Lett. 1999 Oct 4;9(19):2843-8. DM2OLGQ RU https://pubmed.ncbi.nlm.nih.gov/10522703 DM2OLGQ DI DM2OLGQ DM2OLGQ DN SNAP-5150 DM2OLGQ MI TTWM4TY DM2OLGQ MN Adrenergic receptor alpha-2B (ADRA2B) DM2OLGQ MT DTT DM2OLGQ MA Inhibitor DM2OLGQ RN Design and synthesis of novel dihydropyridine alpha-1a antagonists. Bioorg Med Chem Lett. 1999 Oct 4;9(19):2843-8. DM2OLGQ RU https://pubmed.ncbi.nlm.nih.gov/10522703 DM2OLGQ DI DM2OLGQ DM2OLGQ DN SNAP-5150 DM2OLGQ MI TT2NUT5 DM2OLGQ MN Adrenergic receptor alpha-2C (ADRA2C) DM2OLGQ MT DTT DM2OLGQ MA Inhibitor DM2OLGQ RN Design and synthesis of novel dihydropyridine alpha-1a antagonists. Bioorg Med Chem Lett. 1999 Oct 4;9(19):2843-8. DM2OLGQ RU https://pubmed.ncbi.nlm.nih.gov/10522703 DM3KN2F DI DM3KN2F DM3KN2F DN SNAP-7915 DM3KN2F MI TTNGILX DM3KN2F MN Adrenergic receptor alpha-1A (ADRA1A) DM3KN2F MT DTT DM3KN2F MA Inhibitor DM3KN2F RN Pharmacophore identification of alpha(1A)-adrenoceptor antagonists. Bioorg Med Chem Lett. 2005 Feb 1;15(3):657-64. DM3KN2F RU https://pubmed.ncbi.nlm.nih.gov/15664832 DMCHPMA DI DMCHPMA DMCHPMA DN SNAP-8719 DMCHPMA MI TTSQIFT DMCHPMA MN 5-HT 1A receptor (HTR1A) DMCHPMA MT DTT DMCHPMA MA Inhibitor DMCHPMA RN Synthesis and structure-activity relationship of fluoro analogues of 8-{2-[4-(4-methoxyphenyl)piperazin-1yl]ethyl}-8-azaspiro[4.5]decane-7,9-dione ... J Med Chem. 2005 Apr 21;48(8):3076-9. DMCHPMA RU https://pubmed.ncbi.nlm.nih.gov/15828846 DMCHPMA DI DMCHPMA DMCHPMA DN SNAP-8719 DMCHPMA MI TTNGILX DMCHPMA MN Adrenergic receptor alpha-1A (ADRA1A) DMCHPMA MT DTT DMCHPMA MA Inhibitor DMCHPMA RN Synthesis and structure-activity relationship of fluoro analogues of 8-{2-[4-(4-methoxyphenyl)piperazin-1yl]ethyl}-8-azaspiro[4.5]decane-7,9-dione ... J Med Chem. 2005 Apr 21;48(8):3076-9. DMCHPMA RU https://pubmed.ncbi.nlm.nih.gov/15828846 DMCHPMA DI DMCHPMA DMCHPMA DN SNAP-8719 DMCHPMA MI TTBRKXS DMCHPMA MN Adrenergic receptor alpha-1B (ADRA1B) DMCHPMA MT DTT DMCHPMA MA Inhibitor DMCHPMA RN Synthesis and structure-activity relationship of fluoro analogues of 8-{2-[4-(4-methoxyphenyl)piperazin-1yl]ethyl}-8-azaspiro[4.5]decane-7,9-dione ... J Med Chem. 2005 Apr 21;48(8):3076-9. DMCHPMA RU https://pubmed.ncbi.nlm.nih.gov/15828846 DMCHPMA DI DMCHPMA DMCHPMA DN SNAP-8719 DMCHPMA MI TT34BHT DMCHPMA MN Adrenergic receptor alpha-1D (ADRA1D) DMCHPMA MT DTT DMCHPMA MA Inhibitor DMCHPMA RN Synthesis and structure-activity relationship of fluoro analogues of 8-{2-[4-(4-methoxyphenyl)piperazin-1yl]ethyl}-8-azaspiro[4.5]decane-7,9-dione ... J Med Chem. 2005 Apr 21;48(8):3076-9. DMCHPMA RU https://pubmed.ncbi.nlm.nih.gov/15828846 DMMHQDX DI DMMHQDX DMMHQDX DN SNAP-94847 DMMHQDX MI TTNGILX DMMHQDX MN Adrenergic receptor alpha-1A (ADRA1A) DMMHQDX MT DTT DMMHQDX MA Inhibitor DMMHQDX RN Synthesis and SAR investigations for novel melanin-concentrating hormone 1 receptor (MCH1) antagonists part 2: A hybrid strategy combining key frag... J Med Chem. 2007 Aug 9;50(16):3883-90. DMMHQDX RU https://pubmed.ncbi.nlm.nih.gov/17668922 DMMHQDX DI DMMHQDX DMMHQDX DN SNAP-94847 DMMHQDX MI TTEX248 DMMHQDX MN Dopamine D2 receptor (D2R) DMMHQDX MT DTT DMMHQDX MA Inhibitor DMMHQDX RN Synthesis and SAR investigations for novel melanin-concentrating hormone 1 receptor (MCH1) antagonists part 2: A hybrid strategy combining key frag... J Med Chem. 2007 Aug 9;50(16):3883-90. DMMHQDX RU https://pubmed.ncbi.nlm.nih.gov/17668922 DMJI5H0 DI DMJI5H0 DMJI5H0 DN SNC-80 DMJI5H0 MI TT27RFC DMJI5H0 MN Opioid receptor delta (OPRD1) DMJI5H0 MT DTT DMJI5H0 MA Agonist DMJI5H0 RN Nonpeptidic delta-opioid receptor agonists reduce immobility in the forced swim assay in rats. Neuropsychopharmacology. 2002 Jun;26(6):744-55. DMJI5H0 RU https://pubmed.ncbi.nlm.nih.gov/12007745 DMYUH62 DI DMYUH62 DMYUH62 DN SNEWIQPRLPQH DMYUH62 MI TTKPV6O DMYUH62 MN Ephrin type-B receptor 2 (EPHB2) DMYUH62 MT DTT DMYUH62 MA Inhibitor DMYUH62 RN Three-dimensional structure of the EphB2 receptor in complex with an antagonistic peptide reveals a novel mode of inhibition. J Biol Chem. 2007 Dec 14;282(50):36505-13. DMYUH62 RU https://pubmed.ncbi.nlm.nih.gov/17897949 DMOLQNK DI DMOLQNK DMOLQNK DN SNG-163 DMOLQNK MI TTZAYWL DMOLQNK MN Estrogen receptor (ESR) DMOLQNK MT DTT DMOLQNK MA Inhibitor DMOLQNK RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 620). DMOLQNK RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=620 DMCT02Q DI DMCT02Q DMCT02Q DN SNG-8006 DMCT02Q MI TTZAYWL DMCT02Q MN Estrogen receptor (ESR) DMCT02Q MT DTT DMCT02Q MA Antagonist DMCT02Q RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 620). DMCT02Q RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=620 DM6O9DQ DI DM6O9DQ DM6O9DQ DN SNG-8023 DM6O9DQ MI TTZAYWL DM6O9DQ MN Estrogen receptor (ESR) DM6O9DQ MT DTT DM6O9DQ RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 620). DM6O9DQ RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=620 DM0W54R DI DM0W54R DM0W54R DN SNG-8033 DM0W54R MI TTZAYWL DM0W54R MN Estrogen receptor (ESR) DM0W54R MT DTT DM0W54R MA Inhibitor DM0W54R RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 620). DM0W54R RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=620 DMB5A80 DI DMB5A80 DMB5A80 DN SNX-2112 DMB5A80 MI TT78R5H DMB5A80 MN Heat shock protein 90 alpha (HSP90A) DMB5A80 MT DTT DMB5A80 MA Inhibitor DMB5A80 RN Heat shock protein 90: inhibitors in clinical trials. J Med Chem. 2010 Jan 14;53(1):3-17. DMB5A80 RU https://pubmed.ncbi.nlm.nih.gov/20055425 DMSRM49 DI DMSRM49 DMSRM49 DN Sodium 2,3,5,6-tetrafluorobenzoate DMSRM49 MI TTANPDJ DMSRM49 MN Carbonic anhydrase II (CA-II) DMSRM49 MT DTT DMSRM49 MA Inhibitor DMSRM49 RN Carbonic anhydrase inhibitors. Inhibition of the beta-class enzymes from the fungal pathogens Candida albicans and Cryptococcus neoformans with ali... Bioorg Med Chem. 2009 Apr 1;17(7):2654-7. DMSRM49 RU https://pubmed.ncbi.nlm.nih.gov/19297172 DMHPD2Y DI DMHPD2Y DMHPD2Y DN SODIUM CITRATE DMHPD2Y MI TTZHA0O DMHPD2Y MN Carbonic anhydrase IV (CA-IV) DMHPD2Y MT DTT DMHPD2Y MA Inhibitor DMHPD2Y RN Carbonic anhydrase inhibitors. Interaction of isozymes I, II, IV, V, and IX with carboxylates. Bioorg Med Chem Lett. 2005 Feb 1;15(3):573-8. DMHPD2Y RU https://pubmed.ncbi.nlm.nih.gov/15664815 DM2WUZA DI DM2WUZA DM2WUZA DN Sodium maleate DM2WUZA MI TTUNARX DM2WUZA MN Carbonic anhydrase (CA) DM2WUZA MT DTT DM2WUZA MA Inhibitor DM2WUZA RN Carbonic anhydrase inhibitors. Inhibition of the beta-class enzymes from the fungal pathogens Candida albicans and Cryptococcus neoformans with ali... Bioorg Med Chem. 2009 Apr 1;17(7):2654-7. DM2WUZA RU https://pubmed.ncbi.nlm.nih.gov/19297172 DMBVQI4 DI DMBVQI4 DMBVQI4 DN Sodium N-methylphenylaminomethanesulfonate DMBVQI4 MI TT2LVK8 DMBVQI4 MN Carbonic anhydrase IX (CA-IX) DMBVQI4 MT DTT DMBVQI4 MA Inhibitor DMBVQI4 RN Carbonic anhydrase inhibitors. Diazenylbenzenesulfonamides are potent and selective inhibitors of the tumor-associated isozymes IX and XII over the... Bioorg Med Chem. 2009 Oct 15;17(20):7093-9. DMBVQI4 RU https://pubmed.ncbi.nlm.nih.gov/19773173 DMBVQI4 DI DMBVQI4 DMBVQI4 DN Sodium N-methylphenylaminomethanesulfonate DMBVQI4 MI TTSYM0R DMBVQI4 MN Carbonic anhydrase XII (CA-XII) DMBVQI4 MT DTT DMBVQI4 MA Inhibitor DMBVQI4 RN Carbonic anhydrase inhibitors. Diazenylbenzenesulfonamides are potent and selective inhibitors of the tumor-associated isozymes IX and XII over the... Bioorg Med Chem. 2009 Oct 15;17(20):7093-9. DMBVQI4 RU https://pubmed.ncbi.nlm.nih.gov/19773173 DM8CLG2 DI DM8CLG2 DM8CLG2 DN Sodium orthovanadate DM8CLG2 MI TT7YM8D DM8CLG2 MN Protein tyrosine phosphatase IVA 3 (PRL-3) DM8CLG2 MT DTT DM8CLG2 MA Inhibitor DM8CLG2 RN Structure of human PRL-3, the phosphatase associated with cancer metastasis. FEBS Lett. 2004 May 7;565(1-3):181-7. DM8CLG2 RU https://pubmed.ncbi.nlm.nih.gov/15135076 DMESHV2 DI DMESHV2 DMESHV2 DN SODIUM PERFLUOROHEXANESULFONAMIDE DMESHV2 MI TTANPDJ DMESHV2 MN Carbonic anhydrase II (CA-II) DMESHV2 MT DTT DMESHV2 MA Inhibitor DMESHV2 RN Synthesis and investigation of inhibition effect of fluorinated sulfonamide derivatives on carbonic anhydrase. Eur J Med Chem. 2010 Mar;45(3):1225-9. DMESHV2 RU https://pubmed.ncbi.nlm.nih.gov/20036446 DMJ7I4U DI DMJ7I4U DMJ7I4U DN Sodium phenylaminomethanesulfonate DMJ7I4U MI TT2LVK8 DMJ7I4U MN Carbonic anhydrase IX (CA-IX) DMJ7I4U MT DTT DMJ7I4U MA Inhibitor DMJ7I4U RN Carbonic anhydrase inhibitors. Diazenylbenzenesulfonamides are potent and selective inhibitors of the tumor-associated isozymes IX and XII over the... Bioorg Med Chem. 2009 Oct 15;17(20):7093-9. DMJ7I4U RU https://pubmed.ncbi.nlm.nih.gov/19773173 DMJ7I4U DI DMJ7I4U DMJ7I4U DN Sodium phenylaminomethanesulfonate DMJ7I4U MI TTSYM0R DMJ7I4U MN Carbonic anhydrase XII (CA-XII) DMJ7I4U MT DTT DMJ7I4U MA Inhibitor DMJ7I4U RN Carbonic anhydrase inhibitors. Diazenylbenzenesulfonamides are potent and selective inhibitors of the tumor-associated isozymes IX and XII over the... Bioorg Med Chem. 2009 Oct 15;17(20):7093-9. DMJ7I4U RU https://pubmed.ncbi.nlm.nih.gov/19773173 DMXELBI DI DMXELBI DMXELBI DN Sodium phenylarsonate DMXELBI MI TTZHA0O DMXELBI MN Carbonic anhydrase IV (CA-IV) DMXELBI MT DTT DMXELBI MA Inhibitor DMXELBI RN Carbonic anhydrase inhibitors: the membrane-associated isoform XV is highly inhibited by inorganic anions. Bioorg Med Chem Lett. 2009 Feb 15;19(4):1155-8. DMXELBI RU https://pubmed.ncbi.nlm.nih.gov/19128966 DM1G4S9 DI DM1G4S9 DM1G4S9 DN Sodium Phosphate, Dibasic, Anhydrous DM1G4S9 MI TTZHA0O DM1G4S9 MN Carbonic anhydrase IV (CA-IV) DM1G4S9 MT DTT DM1G4S9 MA Inhibitor DM1G4S9 RN Carbonic anhydrase inhibitors. Interaction of isozymes I, II, IV, V, and IX with phosphates, carbamoyl phosphate, and the phosphonate antiviral dru... Bioorg Med Chem Lett. 2004 Dec 6;14(23):5763-7. DM1G4S9 RU https://pubmed.ncbi.nlm.nih.gov/15501037 DM1G4S9 DI DM1G4S9 DM1G4S9 DN Sodium Phosphate, Dibasic, Anhydrous DM1G4S9 MI DEX2KIA DM1G4S9 MN Steroid 17-alpha-monooxygenase (CYP17A1) DM1G4S9 MT DME DM1G4S9 MA Metabolism DM1G4S9 RN Transcriptional complexes at the CYP17 CRS. Endocr Res. 2002 Nov;28(4):551-8. DM1G4S9 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=12530662 DMAMV6T DI DMAMV6T DMAMV6T DN Sodium sulfamate DMAMV6T MI TTZHA0O DMAMV6T MN Carbonic anhydrase IV (CA-IV) DMAMV6T MT DTT DMAMV6T MA Inhibitor DMAMV6T RN Carbonic anhydrase inhibitors: the membrane-associated isoform XV is highly inhibited by inorganic anions. Bioorg Med Chem Lett. 2009 Feb 15;19(4):1155-8. DMAMV6T RU https://pubmed.ncbi.nlm.nih.gov/19128966 DM6WYGC DI DM6WYGC DM6WYGC DN Sodium trithiocarbonate DM6WYGC MI TTHQPL7 DM6WYGC MN Carbonic anhydrase I (CA-I) DM6WYGC MT DTT DM6WYGC MA Inhibitor DM6WYGC RN Carbonic anhydrase inhibitors. Inhibition of cytosolic isoforms I, II, III, VII and XIII with less investigated inorganic anions. Bioorg Med Chem Lett. 2009 Apr 1;19(7):1855-7. DM6WYGC RU https://pubmed.ncbi.nlm.nih.gov/19269822 DM6WYGC DI DM6WYGC DM6WYGC DN Sodium trithiocarbonate DM6WYGC MI TTANPDJ DM6WYGC MN Carbonic anhydrase II (CA-II) DM6WYGC MT DTT DM6WYGC MA Inhibitor DM6WYGC RN Carbonic anhydrase inhibitors. Inhibition of cytosolic isoforms I, II, III, VII and XIII with less investigated inorganic anions. Bioorg Med Chem Lett. 2009 Apr 1;19(7):1855-7. DM6WYGC RU https://pubmed.ncbi.nlm.nih.gov/19269822 DM6WYGC DI DM6WYGC DM6WYGC DN Sodium trithiocarbonate DM6WYGC MI TTZHA0O DM6WYGC MN Carbonic anhydrase IV (CA-IV) DM6WYGC MT DTT DM6WYGC MA Inhibitor DM6WYGC RN Carbonic anhydrase inhibitors. Inhibition of cytosolic isoforms I, II, III, VII and XIII with less investigated inorganic anions. Bioorg Med Chem Lett. 2009 Apr 1;19(7):1855-7. DM6WYGC RU https://pubmed.ncbi.nlm.nih.gov/19269822 DMX6PLV DI DMX6PLV DMX6PLV DN Sodium valproate DMX6PLV MI TTT2LD9 DMX6PLV MN GABA transaminase (ABAT) DMX6PLV MT DTT DMX6PLV MA Inhibitor DMX6PLV RN Influence of a GABA transaminase inhibitor on central nervous system oxygen toxicity. Aviat Space Environ Med. 1978 Jul;49(7):877-9. DMX6PLV RU https://pubmed.ncbi.nlm.nih.gov/352331 DMEZAPR DI DMEZAPR DMEZAPR DN SODIUM ZINC DIHYDROLIPOYLHISTIDINATE DMEZAPR MI TTULVH8 DMEZAPR MN Tyrosinase (TYR) DMEZAPR MT DTT DMEZAPR MA Inhibitor DMEZAPR RN Modulating effects of a novel skin-lightening agent, alpha-lipoic acid derivative, on melanin production by the formation of DOPA conjugate products. Bioorg Med Chem. 2007 Mar 1;15(5):1967-75. DMEZAPR RU https://pubmed.ncbi.nlm.nih.gov/17218103 DMJXN1G DI DMJXN1G DMJXN1G DN Soluble ErbB3 theragnostics DMJXN1G MI TTDC8N2 DMJXN1G MN Erbb3 tyrosine kinase receptor (Erbb-3) DMJXN1G MT DTT DMJXN1G MA Inhibitor DMJXN1G RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1798). DMJXN1G RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1798 DMIOFQE DI DMIOFQE DMIOFQE DN SOMATOSTATIN DMIOFQE MI TT27RFC DMIOFQE MN Opioid receptor delta (OPRD1) DMIOFQE MT DTT DMIOFQE MA Inhibitor DMIOFQE RN Design and synthesis of conformationally constrained somatostatin analogues with high potency and specificity for mu opioid receptors. J Med Chem. 1986 Nov;29(11):2370-5. DMIOFQE RU https://pubmed.ncbi.nlm.nih.gov/2878079 DMIOFQE DI DMIOFQE DMIOFQE DN SOMATOSTATIN DMIOFQE MI TTKWM86 DMIOFQE MN Opioid receptor mu (MOP) DMIOFQE MT DTT DMIOFQE MA Inhibitor DMIOFQE RN Design and synthesis of conformationally constrained somatostatin analogues with high potency and specificity for mu opioid receptors. J Med Chem. 1986 Nov;29(11):2370-5. DMIOFQE RU https://pubmed.ncbi.nlm.nih.gov/2878079 DMIOFQE DI DMIOFQE DMIOFQE DN SOMATOSTATIN DMIOFQE MI TTIND6G DMIOFQE MN Somatostatin receptor type 1 (SSTR1) DMIOFQE MT DTT DMIOFQE MA Inhibitor DMIOFQE RN Discovery of iodinated somatostatin analogues selective for hsst2 and hsst5 with excellent inhibition of growth hormone and prolactin release from ... J Med Chem. 2005 Oct 20;48(21):6643-52. DMIOFQE RU https://pubmed.ncbi.nlm.nih.gov/16220980 DMIOFQE DI DMIOFQE DMIOFQE DN SOMATOSTATIN DMIOFQE MI TTZ6T9E DMIOFQE MN Somatostatin receptor type 2 (SSTR2) DMIOFQE MT DTT DMIOFQE MA Inhibitor DMIOFQE RN Discovery of iodinated somatostatin analogues selective for hsst2 and hsst5 with excellent inhibition of growth hormone and prolactin release from ... J Med Chem. 2005 Oct 20;48(21):6643-52. DMIOFQE RU https://pubmed.ncbi.nlm.nih.gov/16220980 DMIOFQE DI DMIOFQE DMIOFQE DN SOMATOSTATIN DMIOFQE MI TTJX3UE DMIOFQE MN Somatostatin receptor type 3 (SSTR3) DMIOFQE MT DTT DMIOFQE MA Inhibitor DMIOFQE RN Discovery of iodinated somatostatin analogues selective for hsst2 and hsst5 with excellent inhibition of growth hormone and prolactin release from ... J Med Chem. 2005 Oct 20;48(21):6643-52. DMIOFQE RU https://pubmed.ncbi.nlm.nih.gov/16220980 DMIOFQE DI DMIOFQE DMIOFQE DN SOMATOSTATIN DMIOFQE MI TTAE1BR DMIOFQE MN Somatostatin receptor type 4 (SSTR4) DMIOFQE MT DTT DMIOFQE MA Inhibitor DMIOFQE RN Discovery of iodinated somatostatin analogues selective for hsst2 and hsst5 with excellent inhibition of growth hormone and prolactin release from ... J Med Chem. 2005 Oct 20;48(21):6643-52. DMIOFQE RU https://pubmed.ncbi.nlm.nih.gov/16220980 DMIOFQE DI DMIOFQE DMIOFQE DN SOMATOSTATIN DMIOFQE MI TT2BC4G DMIOFQE MN Somatostatin receptor type 5 (SSTR5) DMIOFQE MT DTT DMIOFQE MA Inhibitor DMIOFQE RN Discovery of iodinated somatostatin analogues selective for hsst2 and hsst5 with excellent inhibition of growth hormone and prolactin release from ... J Med Chem. 2005 Oct 20;48(21):6643-52. DMIOFQE RU https://pubmed.ncbi.nlm.nih.gov/16220980 DMH6JI8 DI DMH6JI8 DMH6JI8 DN S-OOPP DMH6JI8 MI TTMN4HY DMH6JI8 MN N-acylethanolamine-hydrolyzing acidamidase (NAAA) DMH6JI8 MT DTT DMH6JI8 MA Inhibitor DMH6JI8 RN Selective N-acylethanolamine-hydrolyzing acid amidase inhibition reveals a key role for endogenous palmitoylethanolamide in inflammation. Proc Natl Acad Sci U S A. 2009 Dec 8;106(49):20966-71. DMH6JI8 RU https://pubmed.ncbi.nlm.nih.gov/19926854 DM8Y1S7 DI DM8Y1S7 DM8Y1S7 DN SOPHOFLAVESCENOL DM8Y1S7 MI TT06AWU DM8Y1S7 MN Phosphodiesterase 3A (PDE3A) DM8Y1S7 MT DTT DM8Y1S7 MA Inhibitor DM8Y1S7 RN A prenylated flavonol, sophoflavescenol: a potent and selective inhibitor of cGMP phosphodiesterase 5. Bioorg Med Chem Lett. 2002 Sep 2;12(17):2313-6. DM8Y1S7 RU https://pubmed.ncbi.nlm.nih.gov/12161123 DM8Y1S7 DI DM8Y1S7 DM8Y1S7 DN SOPHOFLAVESCENOL DM8Y1S7 MI TTZ97H5 DM8Y1S7 MN Phosphodiesterase 4A (PDE4A) DM8Y1S7 MT DTT DM8Y1S7 MA Inhibitor DM8Y1S7 RN A prenylated flavonol, sophoflavescenol: a potent and selective inhibitor of cGMP phosphodiesterase 5. Bioorg Med Chem Lett. 2002 Sep 2;12(17):2313-6. DM8Y1S7 RU https://pubmed.ncbi.nlm.nih.gov/12161123 DM8Y1S7 DI DM8Y1S7 DM8Y1S7 DN SOPHOFLAVESCENOL DM8Y1S7 MI TTVIAT9 DM8Y1S7 MN Phosphodiesterase 4B (PDE4B) DM8Y1S7 MT DTT DM8Y1S7 MA Inhibitor DM8Y1S7 RN A prenylated flavonol, sophoflavescenol: a potent and selective inhibitor of cGMP phosphodiesterase 5. Bioorg Med Chem Lett. 2002 Sep 2;12(17):2313-6. DM8Y1S7 RU https://pubmed.ncbi.nlm.nih.gov/12161123 DM8Y1S7 DI DM8Y1S7 DM8Y1S7 DN SOPHOFLAVESCENOL DM8Y1S7 MI TTJ0IQB DM8Y1S7 MN Phosphodiesterase 5A (PDE5A) DM8Y1S7 MT DTT DM8Y1S7 MA Inhibitor DM8Y1S7 RN A prenylated flavonol, sophoflavescenol: a potent and selective inhibitor of cGMP phosphodiesterase 5. Bioorg Med Chem Lett. 2002 Sep 2;12(17):2313-6. DM8Y1S7 RU https://pubmed.ncbi.nlm.nih.gov/12161123 DMUVKX5 DI DMUVKX5 DMUVKX5 DN SOPHORAFLAVANONE B DMUVKX5 MI TTZAYWL DMUVKX5 MN Estrogen receptor (ESR) DMUVKX5 MT DTT DMUVKX5 MA Inhibitor DMUVKX5 RN Subtle side-chain modifications of the hop phytoestrogen 8-prenylnaringenin result in distinct agonist/antagonist activity profiles for estrogen re... J Med Chem. 2006 Dec 14;49(25):7357-65. DMUVKX5 RU https://pubmed.ncbi.nlm.nih.gov/17149865 DMUVKX5 DI DMUVKX5 DMUVKX5 DN SOPHORAFLAVANONE B DMUVKX5 MI TTOM3J0 DMUVKX5 MN Estrogen receptor beta (ESR2) DMUVKX5 MT DTT DMUVKX5 MA Inhibitor DMUVKX5 RN Subtle side-chain modifications of the hop phytoestrogen 8-prenylnaringenin result in distinct agonist/antagonist activity profiles for estrogen re... J Med Chem. 2006 Dec 14;49(25):7357-65. DMUVKX5 RU https://pubmed.ncbi.nlm.nih.gov/17149865 DMUVKX5 DI DMUVKX5 DMUVKX5 DN SOPHORAFLAVANONE B DMUVKX5 MI TTJ0IQB DMUVKX5 MN Phosphodiesterase 5A (PDE5A) DMUVKX5 MT DTT DMUVKX5 MA Inhibitor DMUVKX5 RN Potent inhibition of human phosphodiesterase-5 by icariin derivatives. J Nat Prod. 2008 Sep;71(9):1513-7. DMUVKX5 RU https://pubmed.ncbi.nlm.nih.gov/18778098 DMBTMN5 DI DMBTMN5 DMBTMN5 DN Sophoraflavanone G DMBTMN5 MI TTF8JAT DMBTMN5 MN SLC5A2 messenger RNA (SLC5A2 mRNA) DMBTMN5 MT DTT DMBTMN5 MA Inhibitor DMBTMN5 RN Na+-glucose cotransporter (SGLT) inhibitory flavonoids from the roots of Sophora flavescens. Bioorg Med Chem. 2007 May 15;15(10):3445-9. DMBTMN5 RU https://pubmed.ncbi.nlm.nih.gov/17374486 DMBTMN5 DI DMBTMN5 DMBTMN5 DN Sophoraflavanone G DMBTMN5 MI TT2UE56 DMBTMN5 MN Sodium/glucose cotransporter 1 (SGLT1) DMBTMN5 MT DTT DMBTMN5 MA Inhibitor DMBTMN5 RN Na+-glucose cotransporter (SGLT) inhibitory flavonoids from the roots of Sophora flavescens. Bioorg Med Chem. 2007 May 15;15(10):3445-9. DMBTMN5 RU https://pubmed.ncbi.nlm.nih.gov/17374486 DM4A0NP DI DM4A0NP DM4A0NP DN SOPHORICOSIDE DM4A0NP MI TTPREZD DM4A0NP MN Interleukin-5 (IL5) DM4A0NP MT DTT DM4A0NP MA Inhibitor DM4A0NP RN Design and synthesis of novel hydroxyalkylaminomethylchromones for their IL-5 inhibitory activity. Bioorg Med Chem. 2010 Jul 1;18(13):4625-9. DM4A0NP RU https://pubmed.ncbi.nlm.nih.gov/20627591 DM18IKZ DI DM18IKZ DM18IKZ DN Soraphen A DM18IKZ MI TTY84UG DM18IKZ MN Acetyl-CoA carboxylase 2 (ACACB) DM18IKZ MT DTT DM18IKZ MA Inhibitor DM18IKZ RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DM18IKZ RU https://pubmed.ncbi.nlm.nih.gov/17139284 DM2TRIZ DI DM2TRIZ DM2TRIZ DN SP-08 DM2TRIZ MI TTE4KHA DM2TRIZ MN Amyloid beta A4 protein (APP) DM2TRIZ MT DTT DM2TRIZ MA Inhibitor DM2TRIZ RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2402). DM2TRIZ RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2402 DM6VQZ7 DI DM6VQZ7 DM6VQZ7 DN SP203 DM6VQZ7 MI TTHS256 DM6VQZ7 MN Metabotropic glutamate receptor 5 (mGluR5) DM6VQZ7 MT DTT DM6VQZ7 MA Modulator (allosteric modulator) DM6VQZ7 RN Synthesis and simple 18F-labeling of 3-fluoro-5-(2-(2-(fluoromethyl)thiazol-4-yl)ethynyl)benzonitrile as a high affinity radioligand for imaging mo... J Med Chem. 2007 Jul 12;50(14):3256-66. DM6VQZ7 RU https://pubmed.ncbi.nlm.nih.gov/17571866 DM5HUY0 DI DM5HUY0 DM5HUY0 DN SP2456 DM5HUY0 MI TTF89GD DM5HUY0 MN Interleukin-2 (IL2) DM5HUY0 MT DTT DM5HUY0 MA Inhibitor DM5HUY0 RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DM5HUY0 RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMLA3WY DI DMLA3WY DMLA3WY DN SP4160 DMLA3WY MI TTF89GD DMLA3WY MN Interleukin-2 (IL2) DMLA3WY MT DTT DMLA3WY MA Inhibitor DMLA3WY RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMLA3WY RU https://pubmed.ncbi.nlm.nih.gov/17139284 DM4SXIT DI DM4SXIT DM4SXIT DN SP-650003 DM4SXIT MI TTSXVID DM4SXIT MN Nuclear factor NF-kappa-B (NFKB) DM4SXIT MT DTT DM4SXIT MA Modulator DM4SXIT RN Book (Current Pharmaceutical Design) DM4SXIT RU https://books.google.com.hk/books?id=ZbENzZB8BwwC&pg=PA523&lpg=PA523&dq=SP-650003&source=bl&ots=n0z8_atusD&sig=HB0ARlN36liy5QcqXckEZyeYPpc&hl=zh-CN&sa=X&ved=0ahUKEwj27ubRtKTKAhUHnZQKHfWTDGoQ6AEIHTAA#v=onepage&q=SP-650003&f=false DMV1W4M DI DMV1W4M DMV1W4M DN Sp-722 DMV1W4M MI TTU6BFZ DMV1W4M MN Candida Thymidylate synthase (Candi TMP1) DMV1W4M MT DTT DMV1W4M MA Inhibitor DMV1W4M RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMV1W4M RU https://pubmed.ncbi.nlm.nih.gov/17139284 DML2V1I DI DML2V1I DML2V1I DN Sp7343-Sp7964 DML2V1I MI TTELIN2 DML2V1I MN PTPN1 messenger RNA (PTPN1 mRNA) DML2V1I MT DTT DML2V1I MA Inhibitor DML2V1I RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DML2V1I RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMJZKEH DI DMJZKEH DMJZKEH DN Sp-876 DMJZKEH MI TTU6BFZ DMJZKEH MN Candida Thymidylate synthase (Candi TMP1) DMJZKEH MT DTT DMJZKEH MA Inhibitor DMJZKEH RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMJZKEH RU https://pubmed.ncbi.nlm.nih.gov/17139284 DM1VQ4K DI DM1VQ4K DM1VQ4K DN Sp-Adenosine-3',5'-Cyclic-Monophosphorothioate DM1VQ4K MI TTNAHEX DM1VQ4K MN cAMP-dependent protein kinase A type I (PRKAR1A) DM1VQ4K MT DTT DM1VQ4K MA Inhibitor DM1VQ4K RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DM1VQ4K RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMV63IP DI DMV63IP DMV63IP DN SPANTIDE DMV63IP MI TTZPO1L DMV63IP MN Substance-P receptor (TACR1) DMV63IP MT DTT DMV63IP MA Inhibitor DMV63IP RN Synthesis and substance P antagonist activity of naphthimidazolium derivatives. J Med Chem. 1992 Apr 3;35(7):1273-9. DMV63IP RU https://pubmed.ncbi.nlm.nih.gov/1373191 DMKC6IX DI DMKC6IX DMKC6IX DN spantide II DMKC6IX MI TTZPO1L DMKC6IX MN Substance-P receptor (TACR1) DMKC6IX MT DTT DMKC6IX MA Antagonist DMKC6IX RN Spantide II, an effective tachykinin antagonist having high potency and negligible neurotoxicity. Proc Natl Acad Sci U S A. 1990 Jun;87(12):4833-5. DMKC6IX RU https://pubmed.ncbi.nlm.nih.gov/1693780 DMWCIMG DI DMWCIMG DMWCIMG DN Sparteine DMWCIMG MI DECB0K3 DMWCIMG MN Cytochrome P450 2D6 (CYP2D6) DMWCIMG MT DME DMWCIMG MA Metabolism DMWCIMG RN Cytochrome P450 2D6.1 and cytochrome P450 2D6.10 differ in catalytic activity for multiple substrates. Pharmacogenetics. 2001 Aug;11(6):477-87. DMWCIMG RU https://www.ncbi.nlm.nih.gov/pubmed/?term=11505218 DMJ6WNK DI DMJ6WNK DMJ6WNK DN Spathodic acid DMJ6WNK MI TTELIN2 DMJ6WNK MN PTPN1 messenger RNA (PTPN1 mRNA) DMJ6WNK MT DTT DMJ6WNK MA Inhibitor DMJ6WNK RN Triterpenoids from the leaves of Diospyros kaki (persimmon) and their inhibitory effects on protein tyrosine phosphatase 1B. J Nat Prod. 2008 Oct;71(10):1775-8. DMJ6WNK RU https://pubmed.ncbi.nlm.nih.gov/18798681 DMFXJKB DI DMFXJKB DMFXJKB DN S-p-bromobenzyl glutatione DMFXJKB MI TTV9A7R DMFXJKB MN Lactoylglutathione lyase (GLO1) DMFXJKB MT DTT DMFXJKB MA Inhibitor DMFXJKB RN Inhibition of glyoxalase I: the first low-nanomolar tight-binding inhibitors. J Med Chem. 2009 Aug 13;52(15):4650-6. DMFXJKB RU https://pubmed.ncbi.nlm.nih.gov/19610604 DM9ZBLE DI DM9ZBLE DM9ZBLE DN Sphinganine DM9ZBLE MI TTO3TD8 DM9ZBLE MN Long transient receptor potential channel 3 (TRPM3) DM9ZBLE MT DTT DM9ZBLE MA Activator DM9ZBLE RN Activation of the melastatin-related cation channel TRPM3 by D-erythro-sphingosine [corrected]. Mol Pharmacol. 2005 Mar;67(3):798-805. DM9ZBLE RU https://pubmed.ncbi.nlm.nih.gov/15550678 DM7ZIMS DI DM7ZIMS DM7ZIMS DN sphingosylphosphorylcholine DM7ZIMS MI TT3IPW2 DM7ZIMS MN G-protein coupled receptor 12 (GPR12) DM7ZIMS MT DTT DM7ZIMS MA Agonist DM7ZIMS RN Role of the G-protein-coupled receptor GPR12 as high-affinity receptor for sphingosylphosphorylcholine and its expression and function in brain development. J Neurosci. 2003 Feb 1;23(3):907-14. DM7ZIMS RU https://pubmed.ncbi.nlm.nih.gov/12574419 DM8MNVX DI DM8MNVX DM8MNVX DN Spingomyelin DM8MNVX MI DEIRJ6O DM8MNVX MN Phospholipase C (plc) DM8MNVX MT DME DM8MNVX MA Metabolism DM8MNVX RN Phospholipase C from Clostridium novyi type A. I. Biochim Biophys Acta. 1975 Oct 21;409(1):75-85. DM8MNVX RU https://pubmed.ncbi.nlm.nih.gov/241423 DMDZIV5 DI DMDZIV5 DMDZIV5 DN spiradoline DMDZIV5 MI TTQW87Y DMDZIV5 MN Opioid receptor kappa (OPRK1) DMDZIV5 MT DTT DMDZIV5 MA Agonist DMDZIV5 RN Cloning and functional comparison of kappa and delta opioid receptors from mouse brain. Proc Natl Acad Sci U S A. 1993 Jul 15;90(14):6736-40. DMDZIV5 RU https://pubmed.ncbi.nlm.nih.gov/8393575 DM5KNMD DI DM5KNMD DM5KNMD DN spiramide DM5KNMD MI TTJQOD7 DM5KNMD MN 5-HT 2A receptor (HTR2A) DM5KNMD MT DTT DM5KNMD MA Antagonist DM5KNMD RN Pharmacological characterisation of the agonist radioligand binding site of 5-HT(2A), 5-HT(2B) and 5-HT(2C) receptors. Naunyn Schmiedebergs Arch Pharmacol. 2004 Aug;370(2):114-23. DM5KNMD RU https://pubmed.ncbi.nlm.nih.gov/15322733 DM5KNMD DI DM5KNMD DM5KNMD DN spiramide DM5KNMD MI TT0K1SC DM5KNMD MN 5-HT 2B receptor (HTR2B) DM5KNMD MT DTT DM5KNMD MA Antagonist DM5KNMD RN Pharmacological characterisation of the agonist radioligand binding site of 5-HT(2A), 5-HT(2B) and 5-HT(2C) receptors. Naunyn Schmiedebergs Arch Pharmacol. 2004 Aug;370(2):114-23. DM5KNMD RU https://pubmed.ncbi.nlm.nih.gov/15322733 DM5KNMD DI DM5KNMD DM5KNMD DN spiramide DM5KNMD MI TTWJBZ5 DM5KNMD MN 5-HT 2C receptor (HTR2C) DM5KNMD MT DTT DM5KNMD MA Antagonist DM5KNMD RN Pharmacological characterisation of the agonist radioligand binding site of 5-HT(2A), 5-HT(2B) and 5-HT(2C) receptors. Naunyn Schmiedebergs Arch Pharmacol. 2004 Aug;370(2):114-23. DM5KNMD RU https://pubmed.ncbi.nlm.nih.gov/15322733 DMGFC8D DI DMGFC8D DMGFC8D DN Spiro[cyclopropane-1,2-adamantan]-2-amine DMGFC8D MI TTXT3PU DMGFC8D MN Influenza M2 protein (Influ M) DMGFC8D MT DTT DMGFC8D MA Inhibitor DMGFC8D RN Antiviral agents active against influenza A viruses. Nat Rev Drug Discov. 2006 Dec;5(12):1015-25. DMGFC8D RU https://pubmed.ncbi.nlm.nih.gov/17139286 DMWU9PV DI DMWU9PV DMWU9PV DN Spiro[piperidine-2,2-adamantane] DMWU9PV MI TTXT3PU DMWU9PV MN Influenza M2 protein (Influ M) DMWU9PV MT DTT DMWU9PV MA Inhibitor DMWU9PV RN Antiviral agents active against influenza A viruses. Nat Rev Drug Discov. 2006 Dec;5(12):1015-25. DMWU9PV RU https://pubmed.ncbi.nlm.nih.gov/17139286 DMW48JD DI DMW48JD DMW48JD DN Spiro[pyrrolidine-2,2-adamantane] DMW48JD MI TTXT3PU DMW48JD MN Influenza M2 protein (Influ M) DMW48JD MT DTT DMW48JD MA Inhibitor DMW48JD RN Antiviral agents active against influenza A viruses. Nat Rev Drug Discov. 2006 Dec;5(12):1015-25. DMW48JD RU https://pubmed.ncbi.nlm.nih.gov/17139286 DMNJVZU DI DMNJVZU DMNJVZU DN SPIROINDANYLOXYMORPHONE DMNJVZU MI TTQW87Y DMNJVZU MN Opioid receptor kappa (OPRK1) DMNJVZU MT DTT DMNJVZU MA Inhibitor DMNJVZU RN Aerobic oxidation of indolomorphinan without the 4,5-epoxy bridge and subsequent rearrangement of the oxidation product to spiroindolinonyl-C-normo... Bioorg Med Chem. 2009 Aug 15;17(16):5983-8. DMNJVZU RU https://pubmed.ncbi.nlm.nih.gov/19620007 DMNJVZU DI DMNJVZU DMNJVZU DN SPIROINDANYLOXYMORPHONE DMNJVZU MI TTKWM86 DMNJVZU MN Opioid receptor mu (MOP) DMNJVZU MT DTT DMNJVZU MA Inhibitor DMNJVZU RN Aerobic oxidation of indolomorphinan without the 4,5-epoxy bridge and subsequent rearrangement of the oxidation product to spiroindolinonyl-C-normo... Bioorg Med Chem. 2009 Aug 15;17(16):5983-8. DMNJVZU RU https://pubmed.ncbi.nlm.nih.gov/19620007 DMPHRXQ DI DMPHRXQ DMPHRXQ DN spiroxatrine DMPHRXQ MI TTSQIFT DMPHRXQ MN 5-HT 1A receptor (HTR1A) DMPHRXQ MT DTT DMPHRXQ MA Agonist DMPHRXQ RN Agonist and antagonist actions of antipsychotic agents at 5-HT1A receptors: a [35S]GTPgammaS binding study. Eur J Pharmacol. 1998 Aug 21;355(2-3):245-56. DMPHRXQ RU https://pubmed.ncbi.nlm.nih.gov/9760039 DMPHRXQ DI DMPHRXQ DMPHRXQ DN spiroxatrine DMPHRXQ MI TT0K1SC DMPHRXQ MN 5-HT 2B receptor (HTR2B) DMPHRXQ MT DTT DMPHRXQ MA Antagonist DMPHRXQ RN [3H]Rauwolscine: an antagonist radioligand for the cloned human 5-hydroxytryptamine2b (5-HT2B) receptor. Naunyn Schmiedebergs Arch Pharmacol. 1998 Jan;357(1):17-24. DMPHRXQ RU https://pubmed.ncbi.nlm.nih.gov/9459568 DMPHRXQ DI DMPHRXQ DMPHRXQ DN spiroxatrine DMPHRXQ MI TTBRKXS DMPHRXQ MN Adrenergic receptor alpha-1B (ADRA1B) DMPHRXQ MT DTT DMPHRXQ MA Antagonist DMPHRXQ RN Affinity of serotonin receptor antagonists and agonists to recombinant and native alpha1-adrenoceptor subtypes. Jpn J Pharmacol. 2001 Jun;86(2):189-95. DMPHRXQ RU https://pubmed.ncbi.nlm.nih.gov/11459121 DMPHRXQ DI DMPHRXQ DMPHRXQ DN spiroxatrine DMPHRXQ MI TTWM4TY DMPHRXQ MN Adrenergic receptor alpha-2B (ADRA2B) DMPHRXQ MT DTT DMPHRXQ MA Antagonist DMPHRXQ RN The novel alpha-2 adrenergic radioligand [3H]-MK912 is alpha-2C selective among human alpha-2A, alpha-2B and alpha-2C adrenoceptors. J Pharmacol Exp Ther. 1994 Dec;271(3):1558-65. DMPHRXQ RU https://pubmed.ncbi.nlm.nih.gov/7996470 DMPHRXQ DI DMPHRXQ DMPHRXQ DN spiroxatrine DMPHRXQ MI TT2NUT5 DMPHRXQ MN Adrenergic receptor alpha-2C (ADRA2C) DMPHRXQ MT DTT DMPHRXQ MA Antagonist DMPHRXQ RN Affinity of serotonin receptor antagonists and agonists to recombinant and native alpha1-adrenoceptor subtypes. Jpn J Pharmacol. 2001 Jun;86(2):189-95. DMPHRXQ RU https://pubmed.ncbi.nlm.nih.gov/11459121 DMCLHZ5 DI DMCLHZ5 DMCLHZ5 DN splitomicin DMCLHZ5 MI TTUF2HO DMCLHZ5 MN NAD-dependent deacetylase sirtuin-1 (SIRT1) DMCLHZ5 MT DTT DMCLHZ5 MA Inhibitor DMCLHZ5 RN Characterization of sirtuin inhibitors in nematodes expressing a muscular dystrophy protein reveals muscle cell and behavioral protection by specif... J Med Chem. 2010 Feb 11;53(3):1407-11. DMCLHZ5 RU https://pubmed.ncbi.nlm.nih.gov/20041717 DMYBCEG DI DMYBCEG DMYBCEG DN S-P-Nitrobenzyloxycarbonylglutathione DMYBCEG MI TTV9A7R DMYBCEG MN Lactoylglutathione lyase (GLO1) DMYBCEG MT DTT DMYBCEG MA Inhibitor DMYBCEG RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMYBCEG RU https://pubmed.ncbi.nlm.nih.gov/17139284 DM0GJVS DI DM0GJVS DM0GJVS DN SPONGIADIOXIN A DM0GJVS MI TTN9T81 DM0GJVS MN Arachidonate 15-lipoxygenase (15-LOX) DM0GJVS MT DTT DM0GJVS MA Inhibitor DM0GJVS RN Probing the activity differences of simple and complex brominated aryl compounds against 15-soybean, 15-human, and 12-human lipoxygenase. J Med Chem. 2004 Jul 29;47(16):4060-5. DM0GJVS RU https://pubmed.ncbi.nlm.nih.gov/15267244 DMP5VN2 DI DMP5VN2 DMP5VN2 DN SPP-800 DMP5VN2 MI TTB2MXP DMP5VN2 MN Angiotensinogenase renin (REN) DMP5VN2 MT DTT DMP5VN2 MA Inhibitor DMP5VN2 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2413). DMP5VN2 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2413 DMFTLY9 DI DMFTLY9 DMFTLY9 DN S-propyl propane-1-sulfinothioate DMFTLY9 MI TT2SUAQ DMFTLY9 MN Cysteine protease (CYP) DMFTLY9 MT DTT DMFTLY9 MA Inhibitor DMFTLY9 RN Allicin and derivates are cysteine protease inhibitors with antiparasitic activity. Bioorg Med Chem Lett. 2010 Sep 15;20(18):5541-3. DMFTLY9 RU https://pubmed.ncbi.nlm.nih.gov/20692829 DMKCJQW DI DMKCJQW DMKCJQW DN SP-SAP DMKCJQW MI TTZPO1L DMKCJQW MN Substance-P receptor (TACR1) DMKCJQW MT DTT DMKCJQW MA Inhibitor DMKCJQW RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 360). DMKCJQW RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=360 DM94RJW DI DM94RJW DM94RJW DN SPT DM94RJW MI TTSLI08 DM94RJW MN Adenosine receptor (ADOR) DM94RJW MT DTT DM94RJW MA Antagonist DM94RJW RN Pretreatment with angiotensin II activates protein kinase C and limits myocardial infarction in isolated rabbit hearts. J Mol Cell Cardiol. 1995 Mar;27(3):883-92. DM94RJW RU https://pubmed.ncbi.nlm.nih.gov/7602606 DMRP42B DI DMRP42B DMRP42B DN SQ 26655 DMRP42B MI TT2O84V DMRP42B MN Thromboxane A2 receptor (TBXA2R) DMRP42B MT DTT DMRP42B MA Agonist DMRP42B RN Synthesis and in vitro pharmacology of 7-oxabicyclo[2.2.1]heptane analogues of thromboxane A2/PGH2. J Med Chem. 1985 Nov;28(11):1580-90. DMRP42B RU https://pubmed.ncbi.nlm.nih.gov/4067988 DMJW8NV DI DMJW8NV DMJW8NV DN SQ-14603 DMJW8NV MI TT3LJ6G DMJW8NV MN Carboxypeptidase A1 (CPA1) DMJW8NV MT DTT DMJW8NV MA Inhibitor DMJW8NV RN Discovery of potent & selective inhibitors of activated thrombin-activatable fibrinolysis inhibitor for the treatment of thrombosis. J Med Chem. 2007 Nov 29;50(24):6095-103. DMJW8NV RU https://pubmed.ncbi.nlm.nih.gov/17990866 DMW7Y9L DI DMW7Y9L DMW7Y9L DN SQ-24798 DMW7Y9L MI TTP18AY DMW7Y9L MN Carboxypeptidase B2 (CPB2) DMW7Y9L MT DTT DMW7Y9L MA Inhibitor DMW7Y9L RN 3-Mercaptopropionic acids as efficacious inhibitors of activated thrombin activatable fibrinolysis inhibitor (TAFIa). Bioorg Med Chem Lett. 2007 Mar 1;17(5):1349-54. DMW7Y9L RU https://pubmed.ncbi.nlm.nih.gov/17189688 DMLPN95 DI DMLPN95 DMLPN95 DN SQ-27986 DMLPN95 MI TTNVEIR DMLPN95 MN Prostaglandin D2 receptor (PTGDR) DMLPN95 MT DTT DMLPN95 MA Agonist DMLPN95 RN Affinities, selectivities, potencies, and intrinsic activities of natural and synthetic prostanoids using endogenous receptors: focus on DP class prostanoids. J Pharmacol Exp Ther. 2000 May;293(2):321-8. DMLPN95 RU https://pubmed.ncbi.nlm.nih.gov/10772998 DM9G3UD DI DM9G3UD DM9G3UD DN SQ-29548 DM9G3UD MI TT2O84V DM9G3UD MN Thromboxane A2 receptor (TBXA2R) DM9G3UD MT DTT DM9G3UD MA Inhibitor DM9G3UD RN The utilization of recombinant prostanoid receptors to determine the affinities and selectivities of prostaglandins and related analogs. Biochim Biophys Acta. 2000 Jan 17;1483(2):285-93. DM9G3UD RU https://pubmed.ncbi.nlm.nih.gov/10634944 DML6SIE DI DML6SIE DML6SIE DN SQ32,910 DML6SIE MI TTXHYV6 DML6SIE MN Voltage-gated L-type calcium channel (L-CaC) DML6SIE MT DTT DML6SIE MA Blocker DML6SIE RN Molecular determinants of drug binding and action on L-type calcium channels. Annu Rev Pharmacol Toxicol. 1997;37:361-96. DML6SIE RU https://pubmed.ncbi.nlm.nih.gov/9131258 DMBA297 DI DMBA297 DMBA297 DN SR11254 DMBA297 MI TT1Q3IE DMBA297 MN Retinoic acid receptor gamma (RARG) DMBA297 MT DTT DMBA297 MA Inhibitor DMBA297 RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMBA297 RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMPN3Q0 DI DMPN3Q0 DMPN3Q0 DN SR-14136 DMPN3Q0 MI TTNT7K8 DMPN3Q0 MN Nociceptin receptor (OPRL1) DMPN3Q0 MT DTT DMPN3Q0 MA Binder DMPN3Q0 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 320). DMPN3Q0 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=320 DMMXU6R DI DMMXU6R DMMXU6R DN SR142948A DMMXU6R MI TTTUMEP DMMXU6R MN Neurotensin receptor type 1 (NTSR1) DMMXU6R MT DTT DMMXU6R MA Antagonist DMMXU6R RN Biochemical and pharmacological activities of SR 142948A, a new potent neurotensin receptor antagonist. J Pharmacol Exp Ther. 1997 Feb;280(2):802-12. DMMXU6R RU https://pubmed.ncbi.nlm.nih.gov/9023294 DMBRVXY DI DMBRVXY DMBRVXY DN SR144528 DMBRVXY MI TTMSFAW DMBRVXY MN Cannabinoid receptor 2 (CB2) DMBRVXY MT DTT DMBRVXY MA Antagonist DMBRVXY RN Antinociceptive activity of the endogenous fatty acid amide, palmitylethanolamide. Eur J Pharmacol. 2001 May 11;419(2-3):191-8. DMBRVXY RU https://pubmed.ncbi.nlm.nih.gov/11426841 DMPO4WX DI DMPO4WX DMPO4WX DN SR-33805A DMPO4WX MI TT5HONZ DMPO4WX MN Calcium channel unspecific (CaC) DMPO4WX MT DTT DMPO4WX MA Modulator DMPO4WX RN Vascular calcium overload produced by vitamin D3, in rats. Effect of treatment with SR 33805, a novel calcium entry blocker. Cardiovasc Res. 1995 Dec;30(6):1038-43. DMPO4WX RU https://pubmed.ncbi.nlm.nih.gov/8746222 DM3Y09Z DI DM3Y09Z DM3Y09Z DN SR-3850 DM3Y09Z MI TTZN7RP DM3Y09Z MN Rho-associated protein kinase 1 (ROCK1) DM3Y09Z MT DTT DM3Y09Z MA Inhibitor DM3Y09Z RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1503). DM3Y09Z RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1503 DM3Y09Z DI DM3Y09Z DM3Y09Z DN SR-3850 DM3Y09Z MI TTGWKQJ DM3Y09Z MN Rho-associated protein kinase 2 (ROCK2) DM3Y09Z MT DTT DM3Y09Z MA Inhibitor DM3Y09Z RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1504). DM3Y09Z RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1504 DMUHQS9 DI DMUHQS9 DMUHQS9 DN SR48527 DMUHQS9 MI TTTUMEP DMUHQS9 MN Neurotensin receptor type 1 (NTSR1) DMUHQS9 MT DTT DMUHQS9 MA Antagonist DMUHQS9 RN [3H]SR 48692, the first nonpeptide neurotensin antagonist radioligand: characterization of binding properties and evidence for distinct agonist and antagonist binding domains on the rat neurotensin receptor. Mol Pharmacol. 1995 May;47(5):1050-6. DMUHQS9 RU https://pubmed.ncbi.nlm.nih.gov/7746272 DMCRVM2 DI DMCRVM2 DMCRVM2 DN SR-59026 DMCRVM2 MI TTSQIFT DMCRVM2 MN 5-HT 1A receptor (HTR1A) DMCRVM2 MT DTT DMCRVM2 MA Modulator DMCRVM2 RN Effect of SR 59026A, a new 5-HT(1A) receptor agonist, on sexual activity in male rats. Behav Pharmacol. 1995 Apr;6(3):276-282. DMCRVM2 RU https://www.ncbi.nlm.nih.gov/pubmed/11224336 DM2WIGO DI DM2WIGO DM2WIGO DN SR9238 DM2WIGO MI TTECBXN DM2WIGO MN Oxysterols receptor LXR-alpha (NR1H3) DM2WIGO MT DTT DM2WIGO MA Antagonist DM2WIGO RN A liver-selective LXR inverse agonist that suppresses hepatic steatosis. ACS Chem Biol. 2013 Mar 15;8(3):559-67. DM2WIGO RU https://pubmed.ncbi.nlm.nih.gov/23237488 DM2WIGO DI DM2WIGO DM2WIGO DN SR9238 DM2WIGO MI TTXA6PH DM2WIGO MN Oxysterols receptor LXR-beta (NR1H2) DM2WIGO MT DTT DM2WIGO MA Antagonist DM2WIGO RN A liver-selective LXR inverse agonist that suppresses hepatic steatosis. ACS Chem Biol. 2013 Mar 15;8(3):559-67. DM2WIGO RU https://pubmed.ncbi.nlm.nih.gov/23237488 DMA28ZX DI DMA28ZX DMA28ZX DN SR95531 DMA28ZX MI TTNJYV2 DMA28ZX MN Gamma-aminobutyric acid receptor (GAR) DMA28ZX MT DTT DMA28ZX MA Antagonist DMA28ZX RN GABA receptors inhibited by benzodiazepines mediate fast inhibitory transmission in the central amygdala. J Neurosci. 1999 Nov 15;19(22):9698-704. DMA28ZX RU https://pubmed.ncbi.nlm.nih.gov/10559379 DMU48OD DI DMU48OD DMU48OD DN SR-973 DMU48OD MI TTE4KHA DMU48OD MN Amyloid beta A4 protein (APP) DMU48OD MT DTT DMU48OD MA Inhibitor DMU48OD RN Synthesis and evaluation of succinoyl-caprolactam gamma-secretase inhibitors. Bioorg Med Chem Lett. 2006 May 1;16(9):2357-63. DMU48OD RU https://pubmed.ncbi.nlm.nih.gov/16473009 DMU48OD DI DMU48OD DMU48OD DN SR-973 DMU48OD MI TTMX39J DMU48OD MN Matrix metalloproteinase-1 (MMP-1) DMU48OD MT DTT DMU48OD MA Inhibitor DMU48OD RN Synthesis and evaluation of succinoyl-caprolactam gamma-secretase inhibitors. Bioorg Med Chem Lett. 2006 May 1;16(9):2357-63. DMU48OD RU https://pubmed.ncbi.nlm.nih.gov/16473009 DMU48OD DI DMU48OD DMU48OD DN SR-973 DMU48OD MI TTHY57M DMU48OD MN Matrix metalloproteinase-13 (MMP-13) DMU48OD MT DTT DMU48OD MA Inhibitor DMU48OD RN Synthesis and evaluation of succinoyl-caprolactam gamma-secretase inhibitors. Bioorg Med Chem Lett. 2006 May 1;16(9):2357-63. DMU48OD RU https://pubmed.ncbi.nlm.nih.gov/16473009 DMU48OD DI DMU48OD DMU48OD DN SR-973 DMU48OD MI TTJ4QE7 DMU48OD MN Matrix metalloproteinase-14 (MMP-14) DMU48OD MT DTT DMU48OD MA Inhibitor DMU48OD RN Synthesis and evaluation of succinoyl-caprolactam gamma-secretase inhibitors. Bioorg Med Chem Lett. 2006 May 1;16(9):2357-63. DMU48OD RU https://pubmed.ncbi.nlm.nih.gov/16473009 DMU48OD DI DMU48OD DMU48OD DN SR-973 DMU48OD MI TTLM12X DMU48OD MN Matrix metalloproteinase-2 (MMP-2) DMU48OD MT DTT DMU48OD MA Inhibitor DMU48OD RN Synthesis and evaluation of succinoyl-caprolactam gamma-secretase inhibitors. Bioorg Med Chem Lett. 2006 May 1;16(9):2357-63. DMU48OD RU https://pubmed.ncbi.nlm.nih.gov/16473009 DMU48OD DI DMU48OD DMU48OD DN SR-973 DMU48OD MI TTYRF5E DMU48OD MN Matrix metalloproteinase-21 (MMP-21) DMU48OD MT DTT DMU48OD MA Inhibitor DMU48OD RN Synthesis and evaluation of succinoyl-caprolactam gamma-secretase inhibitors. Bioorg Med Chem Lett. 2006 May 1;16(9):2357-63. DMU48OD RU https://pubmed.ncbi.nlm.nih.gov/16473009 DMU48OD DI DMU48OD DMU48OD DN SR-973 DMU48OD MI TTMTWOS DMU48OD MN Matrix metalloproteinase-7 (MMP-7) DMU48OD MT DTT DMU48OD MA Inhibitor DMU48OD RN Synthesis and evaluation of succinoyl-caprolactam gamma-secretase inhibitors. Bioorg Med Chem Lett. 2006 May 1;16(9):2357-63. DMU48OD RU https://pubmed.ncbi.nlm.nih.gov/16473009 DMU48OD DI DMU48OD DMU48OD DN SR-973 DMU48OD MI TT6X50U DMU48OD MN Matrix metalloproteinase-9 (MMP-9) DMU48OD MT DTT DMU48OD MA Inhibitor DMU48OD RN Synthesis and evaluation of succinoyl-caprolactam gamma-secretase inhibitors. Bioorg Med Chem Lett. 2006 May 1;16(9):2357-63. DMU48OD RU https://pubmed.ncbi.nlm.nih.gov/16473009 DMU48OD DI DMU48OD DMU48OD DN SR-973 DMU48OD MI TT6AZXG DMU48OD MN TNF alpha converting enzyme (ADAM17) DMU48OD MT DTT DMU48OD MA Inhibitor DMU48OD RN Synthesis and evaluation of succinoyl-caprolactam gamma-secretase inhibitors. Bioorg Med Chem Lett. 2006 May 1;16(9):2357-63. DMU48OD RU https://pubmed.ncbi.nlm.nih.gov/16473009 DM37YJH DI DM37YJH DM37YJH DN SRA880 DM37YJH MI TTIND6G DM37YJH MN Somatostatin receptor type 1 (SSTR1) DM37YJH MT DTT DM37YJH MA Antagonist DM37YJH RN SRA880, in vitro characterization of the first non-peptide somatostatin sst(1) receptor antagonist. Neurosci Lett. 2004 May 6;361(1-3):132-5. DM37YJH RU https://pubmed.ncbi.nlm.nih.gov/15135911 DMUZP9V DI DMUZP9V DMUZP9V DN Src kinase inhibitor I DMUZP9V MI TTCQ2E5 DMUZP9V MN RIP2 messenger RNA (RIP2 mRNA) DMUZP9V MT DTT DMUZP9V MA Inhibitor DMUZP9V RN The selectivity of protein kinase inhibitors: a further update. Biochem J. 2007 Dec 15;408(3):297-315. DMUZP9V RU https://pubmed.ncbi.nlm.nih.gov/17850214 DM35NF6 DI DM35NF6 DM35NF6 DN SRI-224 DM35NF6 MI TTULVH8 DM35NF6 MN Tyrosinase (TYR) DM35NF6 MT DTT DM35NF6 MA Inhibitor DM35NF6 RN Discovery of 4-functionalized phenyl-O-beta-D-glycosides as a new class of mushroom tyrosinase inhibitors. Bioorg Med Chem Lett. 2009 Nov 1;19(21):6157-60. DM35NF6 RU https://pubmed.ncbi.nlm.nih.gov/19800229 DM8GDZS DI DM8GDZS DM8GDZS DN SRI-63-675 DM8GDZS MI TTQL5VC DM8GDZS MN Platelet-activating factor receptor (PTAFR) DM8GDZS MT DTT DM8GDZS MA Modulator DM8GDZS RN The effect of SRI 63-675, a competitive platelet-activating factor receptor-antagonist, in the generalized Shwartzman reaction. J Lipid Mediat Cell Signal. 1994 Sep;10(3):229-42. DM8GDZS RU https://www.ncbi.nlm.nih.gov/pubmed/7812674 DM5GILS DI DM5GILS DM5GILS DN Sri-9439 DM5GILS MI TT9SL3Q DM5GILS MN Polypeptide deformylase (PDF) DM5GILS MT DTT DM5GILS MA Inhibitor DM5GILS RN DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Nucleic Acids Res. 2011 Jan;39(Database issue):D1035-41. DM5GILS RU https://pubmed.ncbi.nlm.nih.gov/21059682 DMYO4A3 DI DMYO4A3 DMYO4A3 DN Sri-9662 DMYO4A3 MI TT9SL3Q DMYO4A3 MN Polypeptide deformylase (PDF) DMYO4A3 MT DTT DMYO4A3 MA Inhibitor DMYO4A3 RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMYO4A3 RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMDY1M7 DI DMDY1M7 DMDY1M7 DN SRIF-14 DMDY1M7 MI TTIND6G DMDY1M7 MN Somatostatin receptor type 1 (SSTR1) DMDY1M7 MT DTT DMDY1M7 MA Agonist DMDY1M7 RN Synthesis and biological activities of potent peptidomimetics selective for somatostatin receptor subtype 2. Proc Natl Acad Sci U S A. 1998 Sep 1;95(18):10836-41. DMDY1M7 RU https://pubmed.ncbi.nlm.nih.gov/9724791 DMDY1M7 DI DMDY1M7 DMDY1M7 DN SRIF-14 DMDY1M7 MI TTZ6T9E DMDY1M7 MN Somatostatin receptor type 2 (SSTR2) DMDY1M7 MT DTT DMDY1M7 MA Agonist DMDY1M7 RN [125I][Tyr3]octreotide labels human somatostatin sst2 and sst5 receptors. Eur J Pharmacol. 1998 May 8;348(2-3):311-20. DMDY1M7 RU https://pubmed.ncbi.nlm.nih.gov/9652348 DMDY1M7 DI DMDY1M7 DMDY1M7 DN SRIF-14 DMDY1M7 MI TTJX3UE DMDY1M7 MN Somatostatin receptor type 3 (SSTR3) DMDY1M7 MT DTT DMDY1M7 MA Agonist DMDY1M7 RN A human somatostatin receptor (SSTR3), located on chromosome 22, displays preferential affinity for somatostatin-14 like peptides. FEBS Lett. 1993 Apr 26;321(2-3):279-84. DMDY1M7 RU https://pubmed.ncbi.nlm.nih.gov/8097479 DMDY1M7 DI DMDY1M7 DMDY1M7 DN SRIF-14 DMDY1M7 MI TTAE1BR DMDY1M7 MN Somatostatin receptor type 4 (SSTR4) DMDY1M7 MT DTT DMDY1M7 MA Agonist DMDY1M7 RN Synthesis and biological activities of potent peptidomimetics selective for somatostatin receptor subtype 2. Proc Natl Acad Sci U S A. 1998 Sep 1;95(18):10836-41. DMDY1M7 RU https://pubmed.ncbi.nlm.nih.gov/9724791 DMDY1M7 DI DMDY1M7 DMDY1M7 DN SRIF-14 DMDY1M7 MI TT2BC4G DMDY1M7 MN Somatostatin receptor type 5 (SSTR5) DMDY1M7 MT DTT DMDY1M7 MA Agonist DMDY1M7 RN [125I][Tyr3]octreotide labels human somatostatin sst2 and sst5 receptors. Eur J Pharmacol. 1998 May 8;348(2-3):311-20. DMDY1M7 RU https://pubmed.ncbi.nlm.nih.gov/9652348 DM0OM9L DI DM0OM9L DM0OM9L DN SRIF-28 DM0OM9L MI TTIND6G DM0OM9L MN Somatostatin receptor type 1 (SSTR1) DM0OM9L MT DTT DM0OM9L MA Inhibitor DM0OM9L RN Novel octreotide dicarba-analogues with high affinity and different selectivity for somatostatin receptors. J Med Chem. 2010 Aug 26;53(16):6188-97. DM0OM9L RU https://pubmed.ncbi.nlm.nih.gov/20666484 DM0OM9L DI DM0OM9L DM0OM9L DN SRIF-28 DM0OM9L MI TTZ6T9E DM0OM9L MN Somatostatin receptor type 2 (SSTR2) DM0OM9L MT DTT DM0OM9L MA Inhibitor DM0OM9L RN Novel octreotide dicarba-analogues with high affinity and different selectivity for somatostatin receptors. J Med Chem. 2010 Aug 26;53(16):6188-97. DM0OM9L RU https://pubmed.ncbi.nlm.nih.gov/20666484 DM0OM9L DI DM0OM9L DM0OM9L DN SRIF-28 DM0OM9L MI TTJX3UE DM0OM9L MN Somatostatin receptor type 3 (SSTR3) DM0OM9L MT DTT DM0OM9L MA Inhibitor DM0OM9L RN Novel octreotide dicarba-analogues with high affinity and different selectivity for somatostatin receptors. J Med Chem. 2010 Aug 26;53(16):6188-97. DM0OM9L RU https://pubmed.ncbi.nlm.nih.gov/20666484 DM0OM9L DI DM0OM9L DM0OM9L DN SRIF-28 DM0OM9L MI TTAE1BR DM0OM9L MN Somatostatin receptor type 4 (SSTR4) DM0OM9L MT DTT DM0OM9L MA Inhibitor DM0OM9L RN Novel octreotide dicarba-analogues with high affinity and different selectivity for somatostatin receptors. J Med Chem. 2010 Aug 26;53(16):6188-97. DM0OM9L RU https://pubmed.ncbi.nlm.nih.gov/20666484 DM0OM9L DI DM0OM9L DM0OM9L DN SRIF-28 DM0OM9L MI TT2BC4G DM0OM9L MN Somatostatin receptor type 5 (SSTR5) DM0OM9L MT DTT DM0OM9L MA Inhibitor DM0OM9L RN Novel octreotide dicarba-analogues with high affinity and different selectivity for somatostatin receptors. J Med Chem. 2010 Aug 26;53(16):6188-97. DM0OM9L RU https://pubmed.ncbi.nlm.nih.gov/20666484 DMUKVHQ DI DMUKVHQ DMUKVHQ DN SRT1720 DMUKVHQ MI TTUF2HO DMUKVHQ MN NAD-dependent deacetylase sirtuin-1 (SIRT1) DMUKVHQ MT DTT DMUKVHQ MA Activator DMUKVHQ RN Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes. Nature. 2007 Nov 29;450(7170):712-6. DMUKVHQ RU https://pubmed.ncbi.nlm.nih.gov/18046409 DMF0X2S DI DMF0X2S DMF0X2S DN SSR126768A DMF0X2S MI TTSCIUP DMF0X2S MN Oxytocin receptor (OTR) DMF0X2S MT DTT DMF0X2S MA Antagonist DMF0X2S RN SSR126768A (4-chloro-3-[(3R)-(+)-5-chloro-1-(2,4-dimethoxybenzyl)-3-methyl-2-oxo-2,3-dihydro-1H-indol-3-yl]-N-ethyl-N-(3-pyridylmethyl)-benzamide, ... J Pharmacol Exp Ther. 2004 Apr;309(1):414-24. DMF0X2S RU https://pubmed.ncbi.nlm.nih.gov/14722330 DMF0X2S DI DMF0X2S DMF0X2S DN SSR126768A DMF0X2S MI TT4TFGN DMF0X2S MN Vasopressin V1a receptor (V1AR) DMF0X2S MT DTT DMF0X2S MA Antagonist DMF0X2S RN SSR126768A (4-chloro-3-[(3R)-(+)-5-chloro-1-(2,4-dimethoxybenzyl)-3-methyl-2-oxo-2,3-dihydro-1H-indol-3-yl]-N-ethyl-N-(3-pyridylmethyl)-benzamide, ... J Pharmacol Exp Ther. 2004 Apr;309(1):414-24. DMF0X2S RU https://pubmed.ncbi.nlm.nih.gov/14722330 DMDIYWV DI DMDIYWV DMDIYWV DN S-sulpho-L-cysteine DMDIYWV MI TTQWGU9 DMDIYWV MN Bacterial Aspartate-semialdehyde dehydrogenase (Bact asd2) DMDIYWV MT DTT DMDIYWV MA Inhibitor DMDIYWV RN Petrosamine B, an inhibitor of the Helicobacter pylori enzyme aspartyl semialdehyde dehydrogenase from the Australian sponge Oceanapia sp. J Nat Prod. 2005 May;68(5):804-6. DMDIYWV RU https://pubmed.ncbi.nlm.nih.gov/15921437 DMO7WRU DI DMO7WRU DMO7WRU DN ST074946 DMO7WRU MI TTMBUHI DMO7WRU MN Deneddylase-1 (SENP8) DMO7WRU MT DTT DMO7WRU MA Inhibitor DMO7WRU RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2417). DMO7WRU RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2417 DM14PLC DI DM14PLC DM14PLC DN ST-1025 DM14PLC MI TT9JNIC DM14PLC MN Histamine H3 receptor (H3R) DM14PLC MT DTT DM14PLC MA Inhibitor DM14PLC RN Azole derivatives as histamine H3 receptor antagonists, part 2: C-C and C-S coupled heterocycles. Bioorg Med Chem Lett. 2010 Oct 1;20(19):5883-6. DM14PLC RU https://pubmed.ncbi.nlm.nih.gov/20727744 DMKZJWV DI DMKZJWV DMKZJWV DN ST-1093 DMKZJWV MI TT9JNIC DMKZJWV MN Histamine H3 receptor (H3R) DMKZJWV MT DTT DMKZJWV MA Inhibitor DMKZJWV RN Azole derivatives as histamine H3 receptor antagonists, part 2: C-C and C-S coupled heterocycles. Bioorg Med Chem Lett. 2010 Oct 1;20(19):5883-6. DMKZJWV RU https://pubmed.ncbi.nlm.nih.gov/20727744 DMUTC9Z DI DMUTC9Z DMUTC9Z DN ST-1535 DMUTC9Z MI TTK25J1 DMUTC9Z MN Adenosine A1 receptor (ADORA1) DMUTC9Z MT DTT DMUTC9Z MA Inhibitor DMUTC9Z RN 2-n-Butyl-9-methyl-8-[1,2,3]triazol-2-yl-9H-purin-6-ylamine and analogues as A2A adenosine receptor antagonists. Design, synthesis, and pharmacolog... J Med Chem. 2005 Nov 3;48(22):6887-96. DMUTC9Z RU https://pubmed.ncbi.nlm.nih.gov/16250647 DMUTC9Z DI DMUTC9Z DMUTC9Z DN ST-1535 DMUTC9Z MI TTM2AOE DMUTC9Z MN Adenosine A2a receptor (ADORA2A) DMUTC9Z MT DTT DMUTC9Z MA Inhibitor DMUTC9Z RN 2-Amino-6-furan-2-yl-4-substituted nicotinonitriles as A2A adenosine receptor antagonists. J Med Chem. 2008 Aug 14;51(15):4449-55. DMUTC9Z RU https://pubmed.ncbi.nlm.nih.gov/18637670 DMUTC9Z DI DMUTC9Z DMUTC9Z DN ST-1535 DMUTC9Z MI TTNE7KG DMUTC9Z MN Adenosine A2b receptor (ADORA2B) DMUTC9Z MT DTT DMUTC9Z MA Inhibitor DMUTC9Z RN 2-n-Butyl-9-methyl-8-[1,2,3]triazol-2-yl-9H-purin-6-ylamine and analogues as A2A adenosine receptor antagonists. Design, synthesis, and pharmacolog... J Med Chem. 2005 Nov 3;48(22):6887-96. DMUTC9Z RU https://pubmed.ncbi.nlm.nih.gov/16250647 DMR1G40 DI DMR1G40 DMR1G40 DN ST-1646 DMR1G40 MI TTT1R2L DMR1G40 MN Integrin alpha-V (ITGAV) DMR1G40 MT DTT DMR1G40 MA Inhibitor DMR1G40 RN Discovery of subnanomolar arginine-glycine-aspartate-based alphaVbeta3/alphaVbeta5 integrin binders embedding 4-aminoproline residues. J Med Chem. 2008 Mar 27;51(6):1771-82. DMR1G40 RU https://pubmed.ncbi.nlm.nih.gov/18303826 DMR1G40 DI DMR1G40 DMR1G40 DN ST-1646 DMR1G40 MI TTJA1ZO DMR1G40 MN ITGB3 messenger RNA (ITGB3 mRNA) DMR1G40 MT DTT DMR1G40 MA Inhibitor DMR1G40 RN Discovery of subnanomolar arginine-glycine-aspartate-based alphaVbeta3/alphaVbeta5 integrin binders embedding 4-aminoproline residues. J Med Chem. 2008 Mar 27;51(6):1771-82. DMR1G40 RU https://pubmed.ncbi.nlm.nih.gov/18303826 DM73E0G DI DM73E0G DM73E0G DN ST-2741 DM73E0G MI TT5ZKDI DM73E0G MN Histone deacetylase 6 (HDAC6) DM73E0G MT DTT DM73E0G MA Inhibitor DM73E0G RN Exploring bis-(indolyl)methane moiety as an alternative and innovative CAP group in the design of histone deacetylase (HDAC) inhibitors. Bioorg Med Chem Lett. 2009 May 15;19(10):2840-3. DM73E0G RU https://pubmed.ncbi.nlm.nih.gov/19359173 DMNERM6 DI DMNERM6 DMNERM6 DN ST-2986 DMNERM6 MI TTBH0VX DMNERM6 MN Histone deacetylase (HDAC) DMNERM6 MT DTT DMNERM6 MA Inhibitor DMNERM6 RN N-Hydroxy-(4-oxime)-cinnamide: a versatile scaffold for the synthesis of novel histone deacetylase [correction of deacetilase] (HDAC) inhibitors. Bioorg Med Chem Lett. 2009 Apr 15;19(8):2346-9. DMNERM6 RU https://pubmed.ncbi.nlm.nih.gov/19285395 DMNERM6 DI DMNERM6 DMNERM6 DN ST-2986 DMNERM6 MI TT6R7JZ DMNERM6 MN Histone deacetylase 1 (HDAC1) DMNERM6 MT DTT DMNERM6 MA Inhibitor DMNERM6 RN N-Hydroxy-(4-oxime)-cinnamide: a versatile scaffold for the synthesis of novel histone deacetylase [correction of deacetilase] (HDAC) inhibitors. Bioorg Med Chem Lett. 2009 Apr 15;19(8):2346-9. DMNERM6 RU https://pubmed.ncbi.nlm.nih.gov/19285395 DMNERM6 DI DMNERM6 DMNERM6 DN ST-2986 DMNERM6 MI TTYHPU6 DMNERM6 MN Histone deacetylase 10 (HDAC10) DMNERM6 MT DTT DMNERM6 MA Inhibitor DMNERM6 RN N-Hydroxy-(4-oxime)-cinnamide: a versatile scaffold for the synthesis of novel histone deacetylase [correction of deacetilase] (HDAC) inhibitors. Bioorg Med Chem Lett. 2009 Apr 15;19(8):2346-9. DMNERM6 RU https://pubmed.ncbi.nlm.nih.gov/19285395 DMNERM6 DI DMNERM6 DMNERM6 DN ST-2986 DMNERM6 MI TTSHTOI DMNERM6 MN Histone deacetylase 2 (HDAC2) DMNERM6 MT DTT DMNERM6 MA Inhibitor DMNERM6 RN N-Hydroxy-(4-oxime)-cinnamide: a versatile scaffold for the synthesis of novel histone deacetylase [correction of deacetilase] (HDAC) inhibitors. Bioorg Med Chem Lett. 2009 Apr 15;19(8):2346-9. DMNERM6 RU https://pubmed.ncbi.nlm.nih.gov/19285395 DMNERM6 DI DMNERM6 DMNERM6 DN ST-2986 DMNERM6 MI TT5ZKDI DMNERM6 MN Histone deacetylase 6 (HDAC6) DMNERM6 MT DTT DMNERM6 MA Inhibitor DMNERM6 RN N-Hydroxy-(4-oxime)-cinnamide: a versatile scaffold for the synthesis of novel histone deacetylase [correction of deacetilase] (HDAC) inhibitors. Bioorg Med Chem Lett. 2009 Apr 15;19(8):2346-9. DMNERM6 RU https://pubmed.ncbi.nlm.nih.gov/19285395 DMNERM6 DI DMNERM6 DMNERM6 DN ST-2986 DMNERM6 MI TTT6LFV DMNERM6 MN Histone deacetylase 8 (HDAC8) DMNERM6 MT DTT DMNERM6 MA Inhibitor DMNERM6 RN N-Hydroxy-(4-oxime)-cinnamide: a versatile scaffold for the synthesis of novel histone deacetylase [correction of deacetilase] (HDAC) inhibitors. Bioorg Med Chem Lett. 2009 Apr 15;19(8):2346-9. DMNERM6 RU https://pubmed.ncbi.nlm.nih.gov/19285395 DMWXTM8 DI DMWXTM8 DMWXTM8 DN ST-2987 DMWXTM8 MI TTBH0VX DMWXTM8 MN Histone deacetylase (HDAC) DMWXTM8 MT DTT DMWXTM8 MA Inhibitor DMWXTM8 RN N-Hydroxy-(4-oxime)-cinnamide: a versatile scaffold for the synthesis of novel histone deacetylase [correction of deacetilase] (HDAC) inhibitors. Bioorg Med Chem Lett. 2009 Apr 15;19(8):2346-9. DMWXTM8 RU https://pubmed.ncbi.nlm.nih.gov/19285395 DMWXTM8 DI DMWXTM8 DMWXTM8 DN ST-2987 DMWXTM8 MI TT6R7JZ DMWXTM8 MN Histone deacetylase 1 (HDAC1) DMWXTM8 MT DTT DMWXTM8 MA Inhibitor DMWXTM8 RN N-Hydroxy-(4-oxime)-cinnamide: a versatile scaffold for the synthesis of novel histone deacetylase [correction of deacetilase] (HDAC) inhibitors. Bioorg Med Chem Lett. 2009 Apr 15;19(8):2346-9. DMWXTM8 RU https://pubmed.ncbi.nlm.nih.gov/19285395 DMWXTM8 DI DMWXTM8 DMWXTM8 DN ST-2987 DMWXTM8 MI TTYHPU6 DMWXTM8 MN Histone deacetylase 10 (HDAC10) DMWXTM8 MT DTT DMWXTM8 MA Inhibitor DMWXTM8 RN N-Hydroxy-(4-oxime)-cinnamide: a versatile scaffold for the synthesis of novel histone deacetylase [correction of deacetilase] (HDAC) inhibitors. Bioorg Med Chem Lett. 2009 Apr 15;19(8):2346-9. DMWXTM8 RU https://pubmed.ncbi.nlm.nih.gov/19285395 DMWXTM8 DI DMWXTM8 DMWXTM8 DN ST-2987 DMWXTM8 MI TTSHTOI DMWXTM8 MN Histone deacetylase 2 (HDAC2) DMWXTM8 MT DTT DMWXTM8 MA Inhibitor DMWXTM8 RN N-Hydroxy-(4-oxime)-cinnamide: a versatile scaffold for the synthesis of novel histone deacetylase [correction of deacetilase] (HDAC) inhibitors. Bioorg Med Chem Lett. 2009 Apr 15;19(8):2346-9. DMWXTM8 RU https://pubmed.ncbi.nlm.nih.gov/19285395 DMWXTM8 DI DMWXTM8 DMWXTM8 DN ST-2987 DMWXTM8 MI TTTQGH8 DMWXTM8 MN Histone deacetylase 4 (HDAC4) DMWXTM8 MT DTT DMWXTM8 MA Inhibitor DMWXTM8 RN N-Hydroxy-(4-oxime)-cinnamide: a versatile scaffold for the synthesis of novel histone deacetylase [correction of deacetilase] (HDAC) inhibitors. Bioorg Med Chem Lett. 2009 Apr 15;19(8):2346-9. DMWXTM8 RU https://pubmed.ncbi.nlm.nih.gov/19285395 DMWXTM8 DI DMWXTM8 DMWXTM8 DN ST-2987 DMWXTM8 MI TT5ZKDI DMWXTM8 MN Histone deacetylase 6 (HDAC6) DMWXTM8 MT DTT DMWXTM8 MA Inhibitor DMWXTM8 RN N-Hydroxy-(4-oxime)-cinnamide: a versatile scaffold for the synthesis of novel histone deacetylase [correction of deacetilase] (HDAC) inhibitors. Bioorg Med Chem Lett. 2009 Apr 15;19(8):2346-9. DMWXTM8 RU https://pubmed.ncbi.nlm.nih.gov/19285395 DMWXTM8 DI DMWXTM8 DMWXTM8 DN ST-2987 DMWXTM8 MI TTT6LFV DMWXTM8 MN Histone deacetylase 8 (HDAC8) DMWXTM8 MT DTT DMWXTM8 MA Inhibitor DMWXTM8 RN N-Hydroxy-(4-oxime)-cinnamide: a versatile scaffold for the synthesis of novel histone deacetylase [correction of deacetilase] (HDAC) inhibitors. Bioorg Med Chem Lett. 2009 Apr 15;19(8):2346-9. DMWXTM8 RU https://pubmed.ncbi.nlm.nih.gov/19285395 DM19K2D DI DM19K2D DM19K2D DN ST-3050 DM19K2D MI TTBH0VX DM19K2D MN Histone deacetylase (HDAC) DM19K2D MT DTT DM19K2D MA Inhibitor DM19K2D RN N-Hydroxy-(4-oxime)-cinnamide: a versatile scaffold for the synthesis of novel histone deacetylase [correction of deacetilase] (HDAC) inhibitors. Bioorg Med Chem Lett. 2009 Apr 15;19(8):2346-9. DM19K2D RU https://pubmed.ncbi.nlm.nih.gov/19285395 DM19K2D DI DM19K2D DM19K2D DN ST-3050 DM19K2D MI TT6R7JZ DM19K2D MN Histone deacetylase 1 (HDAC1) DM19K2D MT DTT DM19K2D MA Inhibitor DM19K2D RN N-Hydroxy-(4-oxime)-cinnamide: a versatile scaffold for the synthesis of novel histone deacetylase [correction of deacetilase] (HDAC) inhibitors. Bioorg Med Chem Lett. 2009 Apr 15;19(8):2346-9. DM19K2D RU https://pubmed.ncbi.nlm.nih.gov/19285395 DM19K2D DI DM19K2D DM19K2D DN ST-3050 DM19K2D MI TTYHPU6 DM19K2D MN Histone deacetylase 10 (HDAC10) DM19K2D MT DTT DM19K2D MA Inhibitor DM19K2D RN N-Hydroxy-(4-oxime)-cinnamide: a versatile scaffold for the synthesis of novel histone deacetylase [correction of deacetilase] (HDAC) inhibitors. Bioorg Med Chem Lett. 2009 Apr 15;19(8):2346-9. DM19K2D RU https://pubmed.ncbi.nlm.nih.gov/19285395 DM19K2D DI DM19K2D DM19K2D DN ST-3050 DM19K2D MI TTTQGH8 DM19K2D MN Histone deacetylase 4 (HDAC4) DM19K2D MT DTT DM19K2D MA Inhibitor DM19K2D RN N-Hydroxy-(4-oxime)-cinnamide: a versatile scaffold for the synthesis of novel histone deacetylase [correction of deacetilase] (HDAC) inhibitors. Bioorg Med Chem Lett. 2009 Apr 15;19(8):2346-9. DM19K2D RU https://pubmed.ncbi.nlm.nih.gov/19285395 DM19K2D DI DM19K2D DM19K2D DN ST-3050 DM19K2D MI TT5ZKDI DM19K2D MN Histone deacetylase 6 (HDAC6) DM19K2D MT DTT DM19K2D MA Inhibitor DM19K2D RN N-Hydroxy-(4-oxime)-cinnamide: a versatile scaffold for the synthesis of novel histone deacetylase [correction of deacetilase] (HDAC) inhibitors. Bioorg Med Chem Lett. 2009 Apr 15;19(8):2346-9. DM19K2D RU https://pubmed.ncbi.nlm.nih.gov/19285395 DM19K2D DI DM19K2D DM19K2D DN ST-3050 DM19K2D MI TTT6LFV DM19K2D MN Histone deacetylase 8 (HDAC8) DM19K2D MT DTT DM19K2D MA Inhibitor DM19K2D RN N-Hydroxy-(4-oxime)-cinnamide: a versatile scaffold for the synthesis of novel histone deacetylase [correction of deacetilase] (HDAC) inhibitors. Bioorg Med Chem Lett. 2009 Apr 15;19(8):2346-9. DM19K2D RU https://pubmed.ncbi.nlm.nih.gov/19285395 DM9FYPM DI DM9FYPM DM9FYPM DN ST-5732 DM9FYPM MI TTBH0VX DM9FYPM MN Histone deacetylase (HDAC) DM9FYPM MT DTT DM9FYPM MA Inhibitor DM9FYPM RN Exploring bis-(indolyl)methane moiety as an alternative and innovative CAP group in the design of histone deacetylase (HDAC) inhibitors. Bioorg Med Chem Lett. 2009 May 15;19(10):2840-3. DM9FYPM RU https://pubmed.ncbi.nlm.nih.gov/19359173 DMIYJ2M DI DMIYJ2M DMIYJ2M DN STA2 DMIYJ2M MI TTPNGDE DMIYJ2M MN Prostaglandin E2 receptor EP3 (PTGER3) DMIYJ2M MT DTT DMIYJ2M MA Agonist DMIYJ2M RN Ligand binding specificities of the eight types and subtypes of the mouse prostanoid receptors expressed in Chinese hamster ovary cells. Br J Pharmacol. 1997 Sep;122(2):217-24. DMIYJ2M RU https://pubmed.ncbi.nlm.nih.gov/9313928 DMIYJ2M DI DMIYJ2M DMIYJ2M DN STA2 DMIYJ2M MI TT2O84V DMIYJ2M MN Thromboxane A2 receptor (TBXA2R) DMIYJ2M MT DTT DMIYJ2M MA Agonist DMIYJ2M RN Ligand binding specificities of the eight types and subtypes of the mouse prostanoid receptors expressed in Chinese hamster ovary cells. Br J Pharmacol. 1997 Sep;122(2):217-24. DMIYJ2M RU https://pubmed.ncbi.nlm.nih.gov/9313928 DMIZESL DI DMIZESL DMIZESL DN Stachyflin DMIZESL MI TTF4CAM DMIZESL MN Influenza Hemagglutinin (Influ HA) DMIZESL MT DTT DMIZESL MA Inhibitor DMIZESL RN Structure of influenza hemagglutinin in complex with an inhibitor of membrane fusion. Proc Natl Acad Sci U S A. 2008 Nov 18;105(46):17736-41. DMIZESL RU https://pubmed.ncbi.nlm.nih.gov/19004788 DM1R9GV DI DM1R9GV DM1R9GV DN Stachyose DM1R9GV MI DE5EODL DM1R9GV MN Beta-fructofuranosidase (BFRU) DM1R9GV MT DME DM1R9GV MA Metabolism DM1R9GV RN Alpha-glactosidase activity of lactobacilli. Appl Microbiol. 1973 Nov;26(5):783-8. DM1R9GV RU https://pubmed.ncbi.nlm.nih.gov/4796954 DM1R9GV DI DM1R9GV DM1R9GV DN Stachyose DM1R9GV MI DER8TO2 DM1R9GV MN Beta-fructofuranosidase (BFRU) DM1R9GV MT DME DM1R9GV MA Metabolism DM1R9GV RN Alpha-glactosidase activity of lactobacilli. Appl Microbiol. 1973 Nov;26(5):783-8. DM1R9GV RU https://pubmed.ncbi.nlm.nih.gov/4796954 DM1R9GV DI DM1R9GV DM1R9GV DN Stachyose DM1R9GV MI DEET5ZQ DM1R9GV MN Beta-fructofuranosidase (BFRU) DM1R9GV MT DME DM1R9GV MA Metabolism DM1R9GV RN Alpha-glactosidase activity of lactobacilli. Appl Microbiol. 1973 Nov;26(5):783-8. DM1R9GV RU https://pubmed.ncbi.nlm.nih.gov/4796954 DM4WQHU DI DM4WQHU DM4WQHU DN Statin DM4WQHU MI TTPADOQ DM4WQHU MN HMG-CoA reductase (HMGCR) DM4WQHU MT DTT DM4WQHU MA Modulator DM4WQHU RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 639). DM4WQHU RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=639 DM0E9BR DI DM0E9BR DM0E9BR DN Staurosporine DM0E9BR MI TTJ3E9X DM0E9BR MN Inhibitor of nuclear factor kappa-B kinase beta (IKKB) DM0E9BR MT DTT DM0E9BR MA Inhibitor DM0E9BR RN UCN-01: a potent abrogator of G2 checkpoint function in cancer cells with disrupted p53. J Natl Cancer Inst. 1996 Jul 17;88(14):956-65. DM0E9BR RU https://pubmed.ncbi.nlm.nih.gov/8667426 DM0E9BR DI DM0E9BR DM0E9BR DN Staurosporine DM0E9BR MI DTUGYRD DM0E9BR MN P-glycoprotein 1 (ABCB1) DM0E9BR MT DTP DM0E9BR MA Substrate DM0E9BR RN Human intestinal transporter database: QSAR modeling and virtual profiling of drug uptake, efflux and interactions. Pharm Res. 2013 Apr;30(4):996-1007. DM0E9BR RU https://doi.org/10.1007/s11095-012-0935-x DM0E9BR DI DM0E9BR DM0E9BR DN Staurosporine DM0E9BR MI TTYVX59 DM0E9BR MN Protein kinase C (PRKC) DM0E9BR MT DTT DM0E9BR MA Inhibitor DM0E9BR RN Protein kinase C zeta isoform is critical for proliferation in human glioblastoma cell lines. J Neurooncol. 2000 Apr;47(2):109-15. DM0E9BR RU https://pubmed.ncbi.nlm.nih.gov/10982151 DMU2H4K DI DMU2H4K DMU2H4K DN STAUROSPORINONE DMU2H4K MI TTZC6DR DMU2H4K MN cGMP-dependent protein kinase (cGK) DMU2H4K MT DTT DMU2H4K MA Inhibitor DMU2H4K RN Non-glycosidic/non-aminoalkyl-substituted indolocarbazoles as inhibitors of protein kinase C, Bioorg. Med. Chem. Lett. 3(10):1959-1964 (1993). DMU2H4K RU http://www.sciencedirect.com/science/article/pii/S0960894X01809951 DMU2H4K DI DMU2H4K DMU2H4K DN STAUROSPORINONE DMU2H4K MI TTRSMW9 DMU2H4K MN Glycogen synthase kinase-3 beta (GSK-3B) DMU2H4K MT DTT DMU2H4K MA Inhibitor DMU2H4K RN Specificity and mechanism of action of some commonly used protein kinase inhibitors. Biochem J. 2000 Oct 1;351(Pt 1):95-105. DMU2H4K RU https://pubmed.ncbi.nlm.nih.gov/10998351 DMU2H4K DI DMU2H4K DMU2H4K DN STAUROSPORINONE DMU2H4K MI TT860QF DMU2H4K MN LCK tyrosine protein kinase (LCK) DMU2H4K MT DTT DMU2H4K MA Inhibitor DMU2H4K RN Specificity and mechanism of action of some commonly used protein kinase inhibitors. Biochem J. 2000 Oct 1;351(Pt 1):95-105. DMU2H4K RU https://pubmed.ncbi.nlm.nih.gov/10998351 DMU2H4K DI DMU2H4K DMU2H4K DN STAUROSPORINONE DMU2H4K MI TTYT93M DMU2H4K MN MAP kinase p38 (MAPK12) DMU2H4K MT DTT DMU2H4K MA Inhibitor DMU2H4K RN Specificity and mechanism of action of some commonly used protein kinase inhibitors. Biochem J. 2000 Oct 1;351(Pt 1):95-105. DMU2H4K RU https://pubmed.ncbi.nlm.nih.gov/10998351 DMU2H4K DI DMU2H4K DMU2H4K DN STAUROSPORINONE DMU2H4K MI TTFJ8Q1 DMU2H4K MN Protein kinase C alpha (PRKCA) DMU2H4K MT DTT DMU2H4K MA Inhibitor DMU2H4K RN Specificity and mechanism of action of some commonly used protein kinase inhibitors. Biochem J. 2000 Oct 1;351(Pt 1):95-105. DMU2H4K RU https://pubmed.ncbi.nlm.nih.gov/10998351 DMU2H4K DI DMU2H4K DMU2H4K DN STAUROSPORINONE DMU2H4K MI TTWTSCV DMU2H4K MN RAC-alpha serine/threonine-protein kinase (AKT1) DMU2H4K MT DTT DMU2H4K MA Inhibitor DMU2H4K RN Specificity and mechanism of action of some commonly used protein kinase inhibitors. Biochem J. 2000 Oct 1;351(Pt 1):95-105. DMU2H4K RU https://pubmed.ncbi.nlm.nih.gov/10998351 DMU2H4K DI DMU2H4K DMU2H4K DN STAUROSPORINONE DMU2H4K MI TTG0U4H DMU2H4K MN Ribosomal protein S6 kinase beta-1 (S6K1) DMU2H4K MT DTT DMU2H4K MA Inhibitor DMU2H4K RN Specificity and mechanism of action of some commonly used protein kinase inhibitors. Biochem J. 2000 Oct 1;351(Pt 1):95-105. DMU2H4K RU https://pubmed.ncbi.nlm.nih.gov/10998351 DMU2H4K DI DMU2H4K DMU2H4K DN STAUROSPORINONE DMU2H4K MI TTQBR95 DMU2H4K MN Stress-activated protein kinase 2a (p38 alpha) DMU2H4K MT DTT DMU2H4K MA Inhibitor DMU2H4K RN Specificity and mechanism of action of some commonly used protein kinase inhibitors. Biochem J. 2000 Oct 1;351(Pt 1):95-105. DMU2H4K RU https://pubmed.ncbi.nlm.nih.gov/10998351 DMU2H4K DI DMU2H4K DMU2H4K DN STAUROSPORINONE DMU2H4K MI TT73U6C DMU2H4K MN Stress-activated protein kinase 2b (p38 beta) DMU2H4K MT DTT DMU2H4K MA Inhibitor DMU2H4K RN Specificity and mechanism of action of some commonly used protein kinase inhibitors. Biochem J. 2000 Oct 1;351(Pt 1):95-105. DMU2H4K RU https://pubmed.ncbi.nlm.nih.gov/10998351 DMU2H4K DI DMU2H4K DMU2H4K DN STAUROSPORINONE DMU2H4K MI TT0K6EO DMU2H4K MN Stress-activated protein kinase JNK1 (JNK1) DMU2H4K MT DTT DMU2H4K MA Inhibitor DMU2H4K RN Specificity and mechanism of action of some commonly used protein kinase inhibitors. Biochem J. 2000 Oct 1;351(Pt 1):95-105. DMU2H4K RU https://pubmed.ncbi.nlm.nih.gov/10998351 DMGMXQC DI DMGMXQC DMGMXQC DN STEPHOLIDINE DMGMXQC MI TTZFYLI DMGMXQC MN Dopamine D1 receptor (D1R) DMGMXQC MT DTT DMGMXQC MA Inhibitor DMGMXQC RN Dibenzazecine scaffold rebuilding--is the flexibility always essential for high dopamine receptor affinities Bioorg Med Chem. 2009 Oct 1;17(19):6898-907. DMGMXQC RU https://pubmed.ncbi.nlm.nih.gov/19744859 DMGMXQC DI DMGMXQC DMGMXQC DN STEPHOLIDINE DMGMXQC MI TTEX248 DMGMXQC MN Dopamine D2 receptor (D2R) DMGMXQC MT DTT DMGMXQC MA Inhibitor DMGMXQC RN Dibenzazecine scaffold rebuilding--is the flexibility always essential for high dopamine receptor affinities Bioorg Med Chem. 2009 Oct 1;17(19):6898-907. DMGMXQC RU https://pubmed.ncbi.nlm.nih.gov/19744859 DMGMXQC DI DMGMXQC DMGMXQC DN STEPHOLIDINE DMGMXQC MI TT4C8EA DMGMXQC MN Dopamine D3 receptor (D3R) DMGMXQC MT DTT DMGMXQC MA Inhibitor DMGMXQC RN Dibenzazecine scaffold rebuilding--is the flexibility always essential for high dopamine receptor affinities Bioorg Med Chem. 2009 Oct 1;17(19):6898-907. DMGMXQC RU https://pubmed.ncbi.nlm.nih.gov/19744859 DMGMXQC DI DMGMXQC DMGMXQC DN STEPHOLIDINE DMGMXQC MI TTE0A2F DMGMXQC MN Dopamine D4 receptor (D4R) DMGMXQC MT DTT DMGMXQC MA Inhibitor DMGMXQC RN Dibenzazecine scaffold rebuilding--is the flexibility always essential for high dopamine receptor affinities Bioorg Med Chem. 2009 Oct 1;17(19):6898-907. DMGMXQC RU https://pubmed.ncbi.nlm.nih.gov/19744859 DMGMXQC DI DMGMXQC DMGMXQC DN STEPHOLIDINE DMGMXQC MI TTS2PH3 DMGMXQC MN Dopamine D5 receptor (D5R) DMGMXQC MT DTT DMGMXQC MA Inhibitor DMGMXQC RN Dibenzazecine scaffold rebuilding--is the flexibility always essential for high dopamine receptor affinities Bioorg Med Chem. 2009 Oct 1;17(19):6898-907. DMGMXQC RU https://pubmed.ncbi.nlm.nih.gov/19744859 DM1PMR3 DI DM1PMR3 DM1PMR3 DN Sterculic acid DM1PMR3 MI TT6RIOV DM1PMR3 MN Acyl-CoA desaturase (SCD) DM1PMR3 MT DTT DM1PMR3 MA Inhibitor DM1PMR3 RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015 DM1PMR3 RU https://www.accessdata.fda.gov/scripts/cder/drugsatfda/ DMZSOG2 DI DMZSOG2 DMZSOG2 DN STO609 DMZSOG2 MI TTV298Y DMZSOG2 MN Calmodulin-dependent kinase II (CAMKK2) DMZSOG2 MT DTT DMZSOG2 MA Inhibitor DMZSOG2 RN STO-609, a specific inhibitor of the Ca(2+)/calmodulin-dependent protein kinase kinase. J Biol Chem. 2002 May 3;277(18):15813-8. DMZSOG2 RU https://pubmed.ncbi.nlm.nih.gov/11867640 DMZSOG2 DI DMZSOG2 DMZSOG2 DN STO609 DMZSOG2 MI TTGLQWZ DMZSOG2 MN CaM-kinase IV kinase (CAMKK1) DMZSOG2 MT DTT DMZSOG2 MA Inhibitor DMZSOG2 RN STO-609, a specific inhibitor of the Ca(2+)/calmodulin-dependent protein kinase kinase. J Biol Chem. 2002 May 3;277(18):15813-8. DMZSOG2 RU https://pubmed.ncbi.nlm.nih.gov/11867640 DM0HOEA DI DM0HOEA DM0HOEA DN streptonigrin DM0HOEA MI TTSCHFW DM0HOEA MN Peptidyl arginine deiminase type III (PADI3) DM0HOEA MT DTT DM0HOEA MA Inhibitor DM0HOEA RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2878). DM0HOEA RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2878 DM0HOEA DI DM0HOEA DM0HOEA DN streptonigrin DM0HOEA MI TTQHAXM DM0HOEA MN Peptidyl arginine deiminase type IV (PADI4) DM0HOEA MT DTT DM0HOEA MA Inhibitor DM0HOEA RN A fluopol-ABPP HTS assay to identify PAD inhibitors. Chem Commun (Camb). 2010 Oct 14;46(38):7175-7. DM0HOEA RU https://pubmed.ncbi.nlm.nih.gov/20740228 DM5BATX DI DM5BATX DM5BATX DN STS-T4 DM5BATX MI TTIHYA4 DM5BATX MN Thrombopoietin receptor (MPL) DM5BATX MT DTT DM5BATX MA Agonist DM5BATX RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1722). DM5BATX RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1722 DM9UHCY DI DM9UHCY DM9UHCY DN S-tubercidinylhomocysteine DM9UHCY MI TTHVCUP DM9UHCY MN DNA [cytosine-5]-methyltransferase (DNMT) DM9UHCY MT DTT DM9UHCY MA Inhibitor DM9UHCY RN SAR around (l)-S-adenosyl-l-homocysteine, an inhibitor of human DNA methyltransferase (DNMT) enzymes. Bioorg Med Chem Lett. 2009 May 15;19(10):2747-51. DM9UHCY RU https://pubmed.ncbi.nlm.nih.gov/19362833 DM9UHCY DI DM9UHCY DM9UHCY DN S-tubercidinylhomocysteine DM9UHCY MI TT6VZ78 DM9UHCY MN DNA [cytosine-5]-methyltransferase 3B (DNMT3B) DM9UHCY MT DTT DM9UHCY MA Inhibitor DM9UHCY RN SAR around (l)-S-adenosyl-l-homocysteine, an inhibitor of human DNA methyltransferase (DNMT) enzymes. Bioorg Med Chem Lett. 2009 May 15;19(10):2747-51. DM9UHCY RU https://pubmed.ncbi.nlm.nih.gov/19362833 DM7LZJ3 DI DM7LZJ3 DM7LZJ3 DN STX DM7LZJ3 MI TTZAYWL DM7LZJ3 MN Estrogen receptor (ESR) DM7LZJ3 MT DTT DM7LZJ3 MA Modulator DM7LZJ3 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 620). DM7LZJ3 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=620 DMO9VWJ DI DMO9VWJ DMO9VWJ DN STYLISSADINE A DMO9VWJ MI TT473XN DMO9VWJ MN P2X purinoceptor 7 (P2RX7) DMO9VWJ MT DTT DMO9VWJ MA Inhibitor DMO9VWJ RN Purinergic P2X(7) receptor antagonists: Chemistry and fundamentals of biological screening. Bioorg Med Chem. 2009 Jul 15;17(14):4861-5. DMO9VWJ RU https://pubmed.ncbi.nlm.nih.gov/19540765 DMNAYEP DI DMNAYEP DMNAYEP DN STYLISSADINE B DMNAYEP MI TT473XN DMNAYEP MN P2X purinoceptor 7 (P2RX7) DMNAYEP MT DTT DMNAYEP MA Inhibitor DMNAYEP RN Purinergic P2X(7) receptor antagonists: Chemistry and fundamentals of biological screening. Bioorg Med Chem. 2009 Jul 15;17(14):4861-5. DMNAYEP RU https://pubmed.ncbi.nlm.nih.gov/19540765 DMJ4Z7W DI DMJ4Z7W DMJ4Z7W DN Styrylboronic acid DMJ4Z7W MI TTHQPL7 DMJ4Z7W MN Carbonic anhydrase I (CA-I) DMJ4Z7W MT DTT DMJ4Z7W MA Inhibitor DMJ4Z7W RN Carbonic anhydrase inhibitors. Inhibition of the fungal beta-carbonic anhydrases from Candida albicans and Cryptococcus neoformans with boronic acids. Bioorg Med Chem Lett. 2009 May 15;19(10):2642-5. DMJ4Z7W RU https://pubmed.ncbi.nlm.nih.gov/19375309 DMF1P6W DI DMF1P6W DMF1P6W DN SU 6656 DMF1P6W MI TTLAFZV DMF1P6W MN AMP-activated protein kinase (AMPK) DMF1P6W MT DTT DMF1P6W MA Inhibitor DMF1P6W RN The selectivity of protein kinase inhibitors: a further update. Biochem J. 2007 Dec 15;408(3):297-315. DMF1P6W RU https://pubmed.ncbi.nlm.nih.gov/17850214 DMF1P6W DI DMF1P6W DMF1P6W DN SU 6656 DMF1P6W MI TT9RTBL DMF1P6W MN Aurora B messenger RNA (AURKB mRNA) DMF1P6W MT DTT DMF1P6W MA Inhibitor DMF1P6W RN The selectivity of protein kinase inhibitors: a further update. Biochem J. 2007 Dec 15;408(3):297-315. DMF1P6W RU https://pubmed.ncbi.nlm.nih.gov/17850214 DMF1P6W DI DMF1P6W DMF1P6W DN SU 6656 DMF1P6W MI TTLYXIT DMF1P6W MN Aurora kinase C (AURKC) DMF1P6W MT DTT DMF1P6W MA Inhibitor DMF1P6W RN The selectivity of protein kinase inhibitors: a further update. Biochem J. 2007 Dec 15;408(3):297-315. DMF1P6W RU https://pubmed.ncbi.nlm.nih.gov/17850214 DMF1P6W DI DMF1P6W DMF1P6W DN SU 6656 DMF1P6W MI TT860QF DMF1P6W MN LCK tyrosine protein kinase (LCK) DMF1P6W MT DTT DMF1P6W MA Inhibitor DMF1P6W RN The selectivity of protein kinase inhibitors: a further update. Biochem J. 2007 Dec 15;408(3):297-315. DMF1P6W RU https://pubmed.ncbi.nlm.nih.gov/17850214 DMF1P6W DI DMF1P6W DMF1P6W DN SU 6656 DMF1P6W MI TT6PKBN DMF1P6W MN Proto-oncogene c-Src (SRC) DMF1P6W MT DTT DMF1P6W MA Inhibitor DMF1P6W RN The selectivity of protein kinase inhibitors: a further update. Biochem J. 2007 Dec 15;408(3):297-315. DMF1P6W RU https://pubmed.ncbi.nlm.nih.gov/17850214 DMASP9Z DI DMASP9Z DMASP9Z DN SU11274 DMASP9Z MI TTNDSF4 DMASP9Z MN Proto-oncogene c-Met (MET) DMASP9Z MT DTT DMASP9Z MA Inhibitor DMASP9Z RN Potent and selective inhibitors of the Met [hepatocyte growth factor/scatter factor (HGF/SF) receptor] tyrosine kinase block HGF/SF-induced tumor cell growth and invasion. Mol Cancer Ther. 2003 Nov;2(11):1085-92. DMASP9Z RU https://pubmed.ncbi.nlm.nih.gov/14617781 DMGQXN7 DI DMGQXN7 DMGQXN7 DN SU-11652 DMGQXN7 MI TT8FYO9 DMGQXN7 MN Platelet-derived growth factor receptor alpha (PDGFRA) DMGQXN7 MT DTT DMGQXN7 MA Inhibitor DMGQXN7 RN Discovery of 5-[5-fluoro-2-oxo-1,2- dihydroindol-(3Z)-ylidenemethyl]-2,4- dimethyl-1H-pyrrole-3-carboxylic acid (2-diethylaminoethyl)amide, a novel... J Med Chem. 2003 Mar 27;46(7):1116-9. DMGQXN7 RU https://pubmed.ncbi.nlm.nih.gov/12646019 DMGQXN7 DI DMGQXN7 DMGQXN7 DN SU-11652 DMGQXN7 MI TTI7421 DMGQXN7 MN Platelet-derived growth factor receptor beta (PDGFRB) DMGQXN7 MT DTT DMGQXN7 MA Inhibitor DMGQXN7 RN Discovery of 5-[5-fluoro-2-oxo-1,2- dihydroindol-(3Z)-ylidenemethyl]-2,4- dimethyl-1H-pyrrole-3-carboxylic acid (2-diethylaminoethyl)amide, a novel... J Med Chem. 2003 Mar 27;46(7):1116-9. DMGQXN7 RU https://pubmed.ncbi.nlm.nih.gov/12646019 DMGQXN7 DI DMGQXN7 DMGQXN7 DN SU-11652 DMGQXN7 MI TT2Q6G1 DMGQXN7 MN Vascular endothelial growth factor receptor 1 (FLT-1) DMGQXN7 MT DTT DMGQXN7 MA Inhibitor DMGQXN7 RN Discovery of 5-[5-fluoro-2-oxo-1,2- dihydroindol-(3Z)-ylidenemethyl]-2,4- dimethyl-1H-pyrrole-3-carboxylic acid (2-diethylaminoethyl)amide, a novel... J Med Chem. 2003 Mar 27;46(7):1116-9. DMGQXN7 RU https://pubmed.ncbi.nlm.nih.gov/12646019 DMGQXN7 DI DMGQXN7 DMGQXN7 DN SU-11652 DMGQXN7 MI TTUTJGQ DMGQXN7 MN Vascular endothelial growth factor receptor 2 (KDR) DMGQXN7 MT DTT DMGQXN7 MA Inhibitor DMGQXN7 RN Discovery of 5-[5-fluoro-2-oxo-1,2- dihydroindol-(3Z)-ylidenemethyl]-2,4- dimethyl-1H-pyrrole-3-carboxylic acid (2-diethylaminoethyl)amide, a novel... J Med Chem. 2003 Mar 27;46(7):1116-9. DMGQXN7 RU https://pubmed.ncbi.nlm.nih.gov/12646019 DMWVN8R DI DMWVN8R DMWVN8R DN SU4984 DMWVN8R MI TT0LF7H DMWVN8R MN Fibroblast growth factor receptor (FGFR) DMWVN8R MT DTT DMWVN8R MA Antagonist DMWVN8R RN Tumor angiogenesis as a therapeutic target. Drug Discov Today. 2001 Oct 1;6(19):1005-1024. DMWVN8R RU https://pubmed.ncbi.nlm.nih.gov/11576867 DM9JON3 DI DM9JON3 DM9JON3 DN SU5402 DM9JON3 MI TTST7KB DM9JON3 MN Fibroblast growth factor receptor 3 (FGFR3) DM9JON3 MT DTT DM9JON3 MA Inhibitor DM9JON3 RN Emerging therapies for multiple myeloma. Expert Opin Emerg Drugs. 2009 Mar;14(1):99-127. DM9JON3 RU https://pubmed.ncbi.nlm.nih.gov/19249983 DMV1408 DI DMV1408 DMV1408 DN SU5403 DMV1408 MI TT0LF7H DMV1408 MN Fibroblast growth factor receptor (FGFR) DMV1408 MT DTT DMV1408 MA Antagonist DMV1408 RN Tumor angiogenesis as a therapeutic target. Drug Discov Today. 2001 Oct 1;6(19):1005-1024. DMV1408 RU https://pubmed.ncbi.nlm.nih.gov/11576867 DMDNA23 DI DMDNA23 DMDNA23 DN SU-6689 DMDNA23 MI TTYMGWX DMDNA23 MN PDK-1 messenger RNA (PDK-1 mRNA) DMDNA23 MT DTT DMDNA23 MA Inhibitor DMDNA23 RN Indolinone based phosphoinositide-dependent kinase-1 (PDK1) inhibitors. Part 1: design, synthesis and biological activity. Bioorg Med Chem Lett. 2007 Jul 15;17(14):3814-8. DMDNA23 RU https://pubmed.ncbi.nlm.nih.gov/17531483 DMQHG0R DI DMQHG0R DMQHG0R DN SU9516 DMQHG0R MI TTH6V3D DMQHG0R MN Cyclin-dependent kinase 1 (CDK1) DMQHG0R MT DTT DMQHG0R MA Binder DMQHG0R RN SU9516: biochemical analysis of cdk inhibition and crystal structure in complex with cdk2. Biochem Biophys Res Commun. 2003 Oct 24;310(3):1026-31. DMQHG0R RU https://pubmed.ncbi.nlm.nih.gov/14550307 DMQHG0R DI DMQHG0R DMQHG0R DN SU9516 DMQHG0R MI TT7HF4W DMQHG0R MN Cyclin-dependent kinase 2 (CDK2) DMQHG0R MT DTT DMQHG0R MA Inhibitor DMQHG0R RN Pharmacological inhibitors of cyclin-dependent kinases. Trends Pharmacol Sci. 2002 Sep;23(9):417-25. DMQHG0R RU https://pubmed.ncbi.nlm.nih.gov/12237154 DMQHG0R DI DMQHG0R DMQHG0R DN SU9516 DMQHG0R MI TTL4Q97 DMQHG0R MN Cyclin-dependent kinase 5 (CDK5) DMQHG0R MT DTT DMQHG0R MA Inhibitor DMQHG0R RN Pharmacological inhibitors of cyclin-dependent kinases. Trends Pharmacol Sci. 2002 Sep;23(9):417-25. DMQHG0R RU https://pubmed.ncbi.nlm.nih.gov/12237154 DM4SWQA DI DM4SWQA DM4SWQA DN Sub[-Trp-Arg-Nva-Arg-Tyr-NH2]2 DM4SWQA MI TTRK9JT DM4SWQA MN Neuropeptide Y receptor type 1 (NPY1R) DM4SWQA MT DTT DM4SWQA MA Inhibitor DM4SWQA RN Neuropeptide Y (NPY) Y4 receptor selective agonists based on NPY(32-36): development of an anorectic Y4 receptor selective agonist with picomolar a... J Med Chem. 2006 Apr 20;49(8):2661-5. DM4SWQA RU https://pubmed.ncbi.nlm.nih.gov/16610810 DM4SWQA DI DM4SWQA DM4SWQA DN Sub[-Trp-Arg-Nva-Arg-Tyr-NH2]2 DM4SWQA MI TTJ6WK9 DM4SWQA MN Neuropeptide Y receptor type 2 (NPY2R) DM4SWQA MT DTT DM4SWQA MA Inhibitor DM4SWQA RN Neuropeptide Y (NPY) Y4 receptor selective agonists based on NPY(32-36): development of an anorectic Y4 receptor selective agonist with picomolar a... J Med Chem. 2006 Apr 20;49(8):2661-5. DM4SWQA RU https://pubmed.ncbi.nlm.nih.gov/16610810 DM4SWQA DI DM4SWQA DM4SWQA DN Sub[-Trp-Arg-Nva-Arg-Tyr-NH2]2 DM4SWQA MI TTW4N16 DM4SWQA MN Neuropeptide Y receptor type 4 (NPY4R) DM4SWQA MT DTT DM4SWQA MA Inhibitor DM4SWQA RN Neuropeptide Y (NPY) Y4 receptor selective agonists based on NPY(32-36): development of an anorectic Y4 receptor selective agonist with picomolar a... J Med Chem. 2006 Apr 20;49(8):2661-5. DM4SWQA RU https://pubmed.ncbi.nlm.nih.gov/16610810 DM56MOV DI DM56MOV DM56MOV DN Sub[-Tyr-Arg-Leu-Arg-Tyr-NH2]2 DM56MOV MI TTRK9JT DM56MOV MN Neuropeptide Y receptor type 1 (NPY1R) DM56MOV MT DTT DM56MOV MA Inhibitor DM56MOV RN Neuropeptide Y (NPY) Y4 receptor selective agonists based on NPY(32-36): development of an anorectic Y4 receptor selective agonist with picomolar a... J Med Chem. 2006 Apr 20;49(8):2661-5. DM56MOV RU https://pubmed.ncbi.nlm.nih.gov/16610810 DM56MOV DI DM56MOV DM56MOV DN Sub[-Tyr-Arg-Leu-Arg-Tyr-NH2]2 DM56MOV MI TTJ6WK9 DM56MOV MN Neuropeptide Y receptor type 2 (NPY2R) DM56MOV MT DTT DM56MOV MA Inhibitor DM56MOV RN Neuropeptide Y (NPY) Y4 receptor selective agonists based on NPY(32-36): development of an anorectic Y4 receptor selective agonist with picomolar a... J Med Chem. 2006 Apr 20;49(8):2661-5. DM56MOV RU https://pubmed.ncbi.nlm.nih.gov/16610810 DM56MOV DI DM56MOV DM56MOV DN Sub[-Tyr-Arg-Leu-Arg-Tyr-NH2]2 DM56MOV MI TTW4N16 DM56MOV MN Neuropeptide Y receptor type 4 (NPY4R) DM56MOV MT DTT DM56MOV MA Inhibitor DM56MOV RN Neuropeptide Y (NPY) Y4 receptor selective agonists based on NPY(32-36): development of an anorectic Y4 receptor selective agonist with picomolar a... J Med Chem. 2006 Apr 20;49(8):2661-5. DM56MOV RU https://pubmed.ncbi.nlm.nih.gov/16610810 DMKH9IE DI DMKH9IE DMKH9IE DN subalin DMKH9IE MI TTSIUJ9 DMKH9IE MN Interferon-alpha 2 (IFNA2) DMKH9IE MT DTT DMKH9IE MA Modulator DMKH9IE RN [Adjuvant properties of subalin, a recombinant interferon-producing probiotic].Zh Mikrobiol Epidemiol Immunobiol.2001 Nov-Dec;(6):77-82. DMKH9IE RU https://www.ncbi.nlm.nih.gov/pubmed/11881504 DM235XH DI DM235XH DM235XH DN Suberic bishydroxamic acid DM235XH MI TTBH0VX DM235XH MN Histone deacetylase (HDAC) DM235XH MT DTT DM235XH MA Inhibitor DM235XH RN Anticancer activities of histone deacetylase inhibitors. Nat Rev Drug Discov. 2006 Sep;5(9):769-84. DM235XH RU https://pubmed.ncbi.nlm.nih.gov/16955068 DM8BLXT DI DM8BLXT DM8BLXT DN Subersic acid DM8BLXT MI TTN9T81 DM8BLXT MN Arachidonate 15-lipoxygenase (15-LOX) DM8BLXT MT DTT DM8BLXT MA Inhibitor DM8BLXT RN Exploring sponge-derived terpenoids for their potency and selectivity against 12-human, 15-human, and 15-soybean lipoxygenases. J Nat Prod. 2003 Feb;66(2):230-5. DM8BLXT RU https://pubmed.ncbi.nlm.nih.gov/12608855 DMQ6W4I DI DMQ6W4I DMQ6W4I DN Substance P DMQ6W4I MI DTUGYRD DMQ6W4I MN P-glycoprotein 1 (ABCB1) DMQ6W4I MT DTP DMQ6W4I MA Substrate DMQ6W4I RN Transport of somatostatin and substance P by human P-glycoprotein. FEBS Lett. 2004 Sep 10;574(1-3):55-61. DMQ6W4I RU https://doi.org/10.1016/j.febslet.2004.07.084 DMQ6W4I DI DMQ6W4I DMQ6W4I DN Substance P DMQ6W4I MI TTZPO1L DMQ6W4I MN Substance-P receptor (TACR1) DMQ6W4I MT DTT DMQ6W4I MA Inhibitor DMQ6W4I RN Synthesis and structure-activity relationships of CP-122,721, a second-generation NK-1 receptor antagonist. Bioorg Med Chem Lett. 1998 Feb 3;8(3):281-4. DMQ6W4I RU https://pubmed.ncbi.nlm.nih.gov/9871670 DMPY09A DI DMPY09A DMPY09A DN Succinate DMPY09A MI DTKXTPW DMPY09A MN Sodium/dicarboxylate cotransporter 3 (SLC13A3) DMPY09A MT DTP DMPY09A MA Substrate DMPY09A RN SLC13A3 variants cause acute reversible leukoencephalopathy and -ketoglutarate accumulation. Ann Neurol. 2019 Mar;85(3):385-395. DMPY09A RU http://www.ncbi.nlm.nih.gov/pubmed/30635937 DMPY09A DI DMPY09A DMPY09A DN Succinate DMPY09A MI DTFPWJ9 DMPY09A MN Sodium-coupled citrate transporter (SLC13A5) DMPY09A MT DTP DMPY09A MA Substrate DMPY09A RN SLC13 family of Na+ coupled di- and tri-carboxylate/sulfate transporters. Mol Aspects Med. 2013 Apr-Jun;34(2-3):299-312. DMPY09A RU http://www.ncbi.nlm.nih.gov/pubmed/23506872 DMVWUCF DI DMVWUCF DMVWUCF DN Sucrose DMVWUCF MI DECWNTP DMVWUCF MN Beta-fructofuranosidase (BFRU) DMVWUCF MT DME DMVWUCF MA Metabolism DMVWUCF RN Characterization of fructooligosaccharide-degrading enzymes in human commensal Bifidobacterium longum and Anaerostipes caccae. Biochem Biophys Res Commun. 2019 Oct 15;518(2):294-298. DMVWUCF RU https://pubmed.ncbi.nlm.nih.gov/31420164 DMVWUCF DI DMVWUCF DMVWUCF DN Sucrose DMVWUCF MI DEBW1FU DMVWUCF MN Fructokinase (scrK) DMVWUCF MT DME DMVWUCF MA Metabolism DMVWUCF RN Sugar metabolism by fusobacteria: regulation of transport, phosphorylation, and polymer formation by Fusobacterium mortiferum ATCC 25557. Infect Immun. 1991 Dec;59(12):4547-54. DMVWUCF RU https://pubmed.ncbi.nlm.nih.gov/1937813 DMVWUCF DI DMVWUCF DMVWUCF DN Sucrose DMVWUCF MI DEWRN24 DMVWUCF MN Glucansucrase (gtf106B) DMVWUCF MT DME DMVWUCF MA Metabolism DMVWUCF RN Biosolids application affects the competitive sorption and lability of cadmium, copper, nickel, lead, and zinc in fluvial and calcareous soils. Environ Geochem Health. 2017 Dec;39(6):1365-1379. DMVWUCF RU https://pubmed.ncbi.nlm.nih.gov/28258314 DMVWUCF DI DMVWUCF DMVWUCF DN Sucrose DMVWUCF MI DTNCJAT DMVWUCF MN Membrane-associated transporter protein (SLC45A2) DMVWUCF MT DTP DMVWUCF MA Substrate DMVWUCF RN Identification of amino acids important for substrate specificity in sucrose transporters using gene shuffling. J Biol Chem. 2012 Aug 31;287(36):30296-304. DMVWUCF RU http://www.ncbi.nlm.nih.gov/pubmed/22807445 DMVWUCF DI DMVWUCF DMVWUCF DN Sucrose DMVWUCF MI DTGEFXH DMVWUCF MN Solute carrier family 45 member 3 (SLC45A3) DMVWUCF MT DTP DMVWUCF MA Substrate DMVWUCF RN Putative role of the H(+)/sucrose symporter SLC45A3 as an osmolyte transporter in the kidney. Pflugers Arch. 2016 Aug;468(8):1353-62. DMVWUCF RU http://www.ncbi.nlm.nih.gov/pubmed/27228996 DMVWUCF DI DMVWUCF DMVWUCF DN Sucrose DMVWUCF MI DTKPHZ6 DMVWUCF MN Solute carrier family 45 member 4 (SLC45A4) DMVWUCF MT DTP DMVWUCF MA Substrate DMVWUCF RN The SLC45 gene family of putative sugar transporters. Mol Aspects Med. 2013 Apr-Jun;34(2-3):655-60. DMVWUCF RU http://www.ncbi.nlm.nih.gov/pubmed/23506898 DMVWUCF DI DMVWUCF DMVWUCF DN Sucrose DMVWUCF MI TTHI19T DMVWUCF MN Staphylococcus Beta-lactamase (Stap-coc blaZ) DMVWUCF MT DTT DMVWUCF MA Inhibitor DMVWUCF RN Ten S, Maclaren N: Insulin resistance syndrome in children. J Clin Endocrinol Metab. 2004 Jun;89(6):2526-39. DMVWUCF RU https://pubmed.ncbi.nlm.nih.gov/15181020 DMVWUCF DI DMVWUCF DMVWUCF DN Sucrose DMVWUCF MI DEJ4FO2 DMVWUCF MN Sucrose phosphorylase (Spase) DMVWUCF MT DME DMVWUCF MA Metabolism DMVWUCF RN Characterization of fructooligosaccharide-degrading enzymes in human commensal Bifidobacterium longum and Anaerostipes caccae. Biochem Biophys Res Commun. 2019 Oct 15;518(2):294-298. DMVWUCF RU https://pubmed.ncbi.nlm.nih.gov/31420164 DMVWUCF DI DMVWUCF DMVWUCF DN Sucrose DMVWUCF MI DEICTXP DMVWUCF MN Sucrose-6-phosphate hydrolase scrB (ScrB) DMVWUCF MT DME DMVWUCF MA Metabolism DMVWUCF RN Characterization of fructooligosaccharide-degrading enzymes in human commensal Bifidobacterium longum and Anaerostipes caccae. Biochem Biophys Res Commun. 2019 Oct 15;518(2):294-298. DMVWUCF RU https://pubmed.ncbi.nlm.nih.gov/31420164 DMET64R DI DMET64R DMET64R DN Sucrose Octasulfate DMET64R MI TTMY81X DMET64R MN Heparin-binding growth factor 1 (FGF1) DMET64R MT DTT DMET64R MA Inhibitor DMET64R RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMET64R RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMF1589 DI DMF1589 DMF1589 DN SULFAMATE DMF1589 MI TTUNARX DMF1589 MN Carbonic anhydrase (CA) DMF1589 MT DTT DMF1589 MA Inhibitor DMF1589 RN Carbonic anhydrase inhibitors: inhibition of the cytosolic human isozyme VII with anions. Bioorg Med Chem Lett. 2006 Jun 15;16(12):3139-43. DMF1589 RU https://pubmed.ncbi.nlm.nih.gov/16621537 DMF1589 DI DMF1589 DMF1589 DN SULFAMATE DMF1589 MI TTHQPL7 DMF1589 MN Carbonic anhydrase I (CA-I) DMF1589 MT DTT DMF1589 MA Inhibitor DMF1589 RN Carbonic anhydrase inhibitors. Inhibition of the newly isolated murine isozyme XIII with anions. Bioorg Med Chem Lett. 2004 Nov 1;14(21):5435-9. DMF1589 RU https://pubmed.ncbi.nlm.nih.gov/15454240 DMF1589 DI DMF1589 DMF1589 DN SULFAMATE DMF1589 MI TTANPDJ DMF1589 MN Carbonic anhydrase II (CA-II) DMF1589 MT DTT DMF1589 MA Inhibitor DMF1589 RN Carbonic anhydrase inhibitors. Inhibition of the newly isolated murine isozyme XIII with anions. Bioorg Med Chem Lett. 2004 Nov 1;14(21):5435-9. DMF1589 RU https://pubmed.ncbi.nlm.nih.gov/15454240 DMF1589 DI DMF1589 DMF1589 DN SULFAMATE DMF1589 MI TTZHA0O DMF1589 MN Carbonic anhydrase IV (CA-IV) DMF1589 MT DTT DMF1589 MA Inhibitor DMF1589 RN Carbonic anhydrase inhibitors: inhibition of the membrane-bound human isozyme IV with anions. Bioorg Med Chem Lett. 2004 Dec 6;14(23):5769-73. DMF1589 RU https://pubmed.ncbi.nlm.nih.gov/15501038 DMF1589 DI DMF1589 DMF1589 DN SULFAMATE DMF1589 MI TT2LVK8 DMF1589 MN Carbonic anhydrase IX (CA-IX) DMF1589 MT DTT DMF1589 MA Inhibitor DMF1589 RN Carbonic anhydrase inhibitors. Inhibition of isozymes I, II, IV, V, and IX with anions isosteric and isoelectronic with sulfate, nitrate, and carbo... Bioorg Med Chem Lett. 2005 Feb 1;15(3):567-71. DMF1589 RU https://pubmed.ncbi.nlm.nih.gov/15664814 DM9XNSK DI DM9XNSK DM9XNSK DN Sulfamic acid 12-sulfamoyloxy-dodecyl ester DM9XNSK MI TTHQPL7 DM9XNSK MN Carbonic anhydrase I (CA-I) DM9XNSK MT DTT DM9XNSK MA Inhibitor DM9XNSK RN Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, and IX with bis-sulfamates. Bioorg Med Chem Lett. 2005 Feb 1;15(3):579-84. DM9XNSK RU https://pubmed.ncbi.nlm.nih.gov/15664816 DM9XNSK DI DM9XNSK DM9XNSK DN Sulfamic acid 12-sulfamoyloxy-dodecyl ester DM9XNSK MI TTANPDJ DM9XNSK MN Carbonic anhydrase II (CA-II) DM9XNSK MT DTT DM9XNSK MA Inhibitor DM9XNSK RN Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, and IX with bis-sulfamates. Bioorg Med Chem Lett. 2005 Feb 1;15(3):579-84. DM9XNSK RU https://pubmed.ncbi.nlm.nih.gov/15664816 DM9XNSK DI DM9XNSK DM9XNSK DN Sulfamic acid 12-sulfamoyloxy-dodecyl ester DM9XNSK MI TT2LVK8 DM9XNSK MN Carbonic anhydrase IX (CA-IX) DM9XNSK MT DTT DM9XNSK MA Inhibitor DM9XNSK RN Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, and IX with bis-sulfamates. Bioorg Med Chem Lett. 2005 Feb 1;15(3):579-84. DM9XNSK RU https://pubmed.ncbi.nlm.nih.gov/15664816 DM7VBSY DI DM7VBSY DM7VBSY DN Sulfamic acid 16-sulfamoyloxy-hexadecyl ester DM7VBSY MI TTHQPL7 DM7VBSY MN Carbonic anhydrase I (CA-I) DM7VBSY MT DTT DM7VBSY MA Inhibitor DM7VBSY RN Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, and IX with bis-sulfamates. Bioorg Med Chem Lett. 2005 Feb 1;15(3):579-84. DM7VBSY RU https://pubmed.ncbi.nlm.nih.gov/15664816 DM7VBSY DI DM7VBSY DM7VBSY DN Sulfamic acid 16-sulfamoyloxy-hexadecyl ester DM7VBSY MI TTANPDJ DM7VBSY MN Carbonic anhydrase II (CA-II) DM7VBSY MT DTT DM7VBSY MA Inhibitor DM7VBSY RN Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, and IX with bis-sulfamates. Bioorg Med Chem Lett. 2005 Feb 1;15(3):579-84. DM7VBSY RU https://pubmed.ncbi.nlm.nih.gov/15664816 DM7VBSY DI DM7VBSY DM7VBSY DN Sulfamic acid 16-sulfamoyloxy-hexadecyl ester DM7VBSY MI TT2LVK8 DM7VBSY MN Carbonic anhydrase IX (CA-IX) DM7VBSY MT DTT DM7VBSY MA Inhibitor DM7VBSY RN Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, and IX with bis-sulfamates. Bioorg Med Chem Lett. 2005 Feb 1;15(3):579-84. DM7VBSY RU https://pubmed.ncbi.nlm.nih.gov/15664816 DMM70K1 DI DMM70K1 DMM70K1 DN Sulfamic acid 2-nonyl-4-oxo-4H-chromen-6-yl ester DMM70K1 MI TTHM0R1 DMM70K1 MN Steryl-sulfatase (STS) DMM70K1 MT DTT DMM70K1 MA Inhibitor DMM70K1 RN Estrogenic potential of 2-alkyl-4-(thio)chromenone 6-O-sulfamates: potent inhibitors of human steroid sulfatase. J Med Chem. 2003 Nov 6;46(23):5091-4. DMM70K1 RU https://pubmed.ncbi.nlm.nih.gov/14584960 DMSZ50N DI DMSZ50N DMSZ50N DN Sulfamic acid 3-(3-hydroxy-benzoyl)-phenyl ester DMSZ50N MI TTHM0R1 DMSZ50N MN Steryl-sulfatase (STS) DMSZ50N MT DTT DMSZ50N MA Inhibitor DMSZ50N RN 4,4'-Benzophenone-O,O'-disulfamate: a potent inhibitor of steroid sulfatase. Bioorg Med Chem Lett. 2002 Aug 19;12(16):2093-5. DMSZ50N RU https://pubmed.ncbi.nlm.nih.gov/12127511 DMIQWAH DI DMIQWAH DMIQWAH DN Sulfamic acid 3-(3-methoxy-benzoyl)-phenyl ester DMIQWAH MI TTHM0R1 DMIQWAH MN Steryl-sulfatase (STS) DMIQWAH MT DTT DMIQWAH MA Inhibitor DMIQWAH RN 4,4'-Benzophenone-O,O'-disulfamate: a potent inhibitor of steroid sulfatase. Bioorg Med Chem Lett. 2002 Aug 19;12(16):2093-5. DMIQWAH RU https://pubmed.ncbi.nlm.nih.gov/12127511 DMH71N6 DI DMH71N6 DMH71N6 DN Sulfamic acid 3-(4-hydroxy-benzoyl)-phenyl ester DMH71N6 MI TTHM0R1 DMH71N6 MN Steryl-sulfatase (STS) DMH71N6 MT DTT DMH71N6 MA Inhibitor DMH71N6 RN 4,4'-Benzophenone-O,O'-disulfamate: a potent inhibitor of steroid sulfatase. Bioorg Med Chem Lett. 2002 Aug 19;12(16):2093-5. DMH71N6 RU https://pubmed.ncbi.nlm.nih.gov/12127511 DMFVE3N DI DMFVE3N DMFVE3N DN Sulfamic acid 3-(4-methoxy-benzoyl)-phenyl ester DMFVE3N MI TTHM0R1 DMFVE3N MN Steryl-sulfatase (STS) DMFVE3N MT DTT DMFVE3N MA Inhibitor DMFVE3N RN 4,4'-Benzophenone-O,O'-disulfamate: a potent inhibitor of steroid sulfatase. Bioorg Med Chem Lett. 2002 Aug 19;12(16):2093-5. DMFVE3N RU https://pubmed.ncbi.nlm.nih.gov/12127511 DMLXHAI DI DMLXHAI DMLXHAI DN Sulfamic acid 3-benzoyl-phenyl ester DMLXHAI MI TTHM0R1 DMLXHAI MN Steryl-sulfatase (STS) DMLXHAI MT DTT DMLXHAI MA Inhibitor DMLXHAI RN 4,4'-Benzophenone-O,O'-disulfamate: a potent inhibitor of steroid sulfatase. Bioorg Med Chem Lett. 2002 Aug 19;12(16):2093-5. DMLXHAI RU https://pubmed.ncbi.nlm.nih.gov/12127511 DMA0MEV DI DMA0MEV DMA0MEV DN Sulfamic acid 3-sulfamoyloxy-phenyl ester DMA0MEV MI TTHQPL7 DMA0MEV MN Carbonic anhydrase I (CA-I) DMA0MEV MT DTT DMA0MEV MA Inhibitor DMA0MEV RN Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, and IX with bis-sulfamates. Bioorg Med Chem Lett. 2005 Feb 1;15(3):579-84. DMA0MEV RU https://pubmed.ncbi.nlm.nih.gov/15664816 DMA0MEV DI DMA0MEV DMA0MEV DN Sulfamic acid 3-sulfamoyloxy-phenyl ester DMA0MEV MI TTANPDJ DMA0MEV MN Carbonic anhydrase II (CA-II) DMA0MEV MT DTT DMA0MEV MA Inhibitor DMA0MEV RN Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, and IX with bis-sulfamates. Bioorg Med Chem Lett. 2005 Feb 1;15(3):579-84. DMA0MEV RU https://pubmed.ncbi.nlm.nih.gov/15664816 DMA0MEV DI DMA0MEV DMA0MEV DN Sulfamic acid 3-sulfamoyloxy-phenyl ester DMA0MEV MI TT2LVK8 DMA0MEV MN Carbonic anhydrase IX (CA-IX) DMA0MEV MT DTT DMA0MEV MA Inhibitor DMA0MEV RN Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, and IX with bis-sulfamates. Bioorg Med Chem Lett. 2005 Feb 1;15(3):579-84. DMA0MEV RU https://pubmed.ncbi.nlm.nih.gov/15664816 DMSYXHF DI DMSYXHF DMSYXHF DN Sulfamic acid 4-(2-hydroxy-benzoyl)-phenyl ester DMSYXHF MI TTHM0R1 DMSYXHF MN Steryl-sulfatase (STS) DMSYXHF MT DTT DMSYXHF MA Inhibitor DMSYXHF RN 4,4'-Benzophenone-O,O'-disulfamate: a potent inhibitor of steroid sulfatase. Bioorg Med Chem Lett. 2002 Aug 19;12(16):2093-5. DMSYXHF RU https://pubmed.ncbi.nlm.nih.gov/12127511 DM8LWM3 DI DM8LWM3 DM8LWM3 DN Sulfamic acid 4-(2-methoxy-benzoyl)-phenyl ester DM8LWM3 MI TTHM0R1 DM8LWM3 MN Steryl-sulfatase (STS) DM8LWM3 MT DTT DM8LWM3 MA Inhibitor DM8LWM3 RN 4,4'-Benzophenone-O,O'-disulfamate: a potent inhibitor of steroid sulfatase. Bioorg Med Chem Lett. 2002 Aug 19;12(16):2093-5. DM8LWM3 RU https://pubmed.ncbi.nlm.nih.gov/12127511 DMK97WC DI DMK97WC DMK97WC DN Sulfamic acid 4-(3-methoxy-benzoyl)-phenyl ester DMK97WC MI TTHM0R1 DMK97WC MN Steryl-sulfatase (STS) DMK97WC MT DTT DMK97WC MA Inhibitor DMK97WC RN 4,4'-Benzophenone-O,O'-disulfamate: a potent inhibitor of steroid sulfatase. Bioorg Med Chem Lett. 2002 Aug 19;12(16):2093-5. DMK97WC RU https://pubmed.ncbi.nlm.nih.gov/12127511 DMDUW9F DI DMDUW9F DMDUW9F DN Sulfamic acid 4-benzoyl-phenyl ester DMDUW9F MI TTHM0R1 DMDUW9F MN Steryl-sulfatase (STS) DMDUW9F MT DTT DMDUW9F MA Inhibitor DMDUW9F RN 4,4'-Benzophenone-O,O'-disulfamate: a potent inhibitor of steroid sulfatase. Bioorg Med Chem Lett. 2002 Aug 19;12(16):2093-5. DMDUW9F RU https://pubmed.ncbi.nlm.nih.gov/12127511 DMQZGNJ DI DMQZGNJ DMQZGNJ DN Sulfamic acid 4-sulfamoyloxy-butyl ester DMQZGNJ MI TTHQPL7 DMQZGNJ MN Carbonic anhydrase I (CA-I) DMQZGNJ MT DTT DMQZGNJ MA Inhibitor DMQZGNJ RN Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, and IX with bis-sulfamates. Bioorg Med Chem Lett. 2005 Feb 1;15(3):579-84. DMQZGNJ RU https://pubmed.ncbi.nlm.nih.gov/15664816 DMQZGNJ DI DMQZGNJ DMQZGNJ DN Sulfamic acid 4-sulfamoyloxy-butyl ester DMQZGNJ MI TTANPDJ DMQZGNJ MN Carbonic anhydrase II (CA-II) DMQZGNJ MT DTT DMQZGNJ MA Inhibitor DMQZGNJ RN Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, and IX with bis-sulfamates. Bioorg Med Chem Lett. 2005 Feb 1;15(3):579-84. DMQZGNJ RU https://pubmed.ncbi.nlm.nih.gov/15664816 DMQZGNJ DI DMQZGNJ DMQZGNJ DN Sulfamic acid 4-sulfamoyloxy-butyl ester DMQZGNJ MI TT2LVK8 DMQZGNJ MN Carbonic anhydrase IX (CA-IX) DMQZGNJ MT DTT DMQZGNJ MA Inhibitor DMQZGNJ RN Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, and IX with bis-sulfamates. Bioorg Med Chem Lett. 2005 Feb 1;15(3):579-84. DMQZGNJ RU https://pubmed.ncbi.nlm.nih.gov/15664816 DMFJR0S DI DMFJR0S DMFJR0S DN Sulfamic acid 4-sulfamoyloxymethyl-benzyl ester DMFJR0S MI TTANPDJ DMFJR0S MN Carbonic anhydrase II (CA-II) DMFJR0S MT DTT DMFJR0S MA Inhibitor DMFJR0S RN Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, and IX with bis-sulfamates. Bioorg Med Chem Lett. 2005 Feb 1;15(3):579-84. DMFJR0S RU https://pubmed.ncbi.nlm.nih.gov/15664816 DMFJR0S DI DMFJR0S DMFJR0S DN Sulfamic acid 4-sulfamoyloxymethyl-benzyl ester DMFJR0S MI TT2LVK8 DMFJR0S MN Carbonic anhydrase IX (CA-IX) DMFJR0S MT DTT DMFJR0S MA Inhibitor DMFJR0S RN Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, and IX with bis-sulfamates. Bioorg Med Chem Lett. 2005 Feb 1;15(3):579-84. DMFJR0S RU https://pubmed.ncbi.nlm.nih.gov/15664816 DMT3U2D DI DMT3U2D DMT3U2D DN Sulfamic acid 6-sulfamoyloxy-hexyl ester DMT3U2D MI TTHQPL7 DMT3U2D MN Carbonic anhydrase I (CA-I) DMT3U2D MT DTT DMT3U2D MA Inhibitor DMT3U2D RN Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, and IX with bis-sulfamates. Bioorg Med Chem Lett. 2005 Feb 1;15(3):579-84. DMT3U2D RU https://pubmed.ncbi.nlm.nih.gov/15664816 DMT3U2D DI DMT3U2D DMT3U2D DN Sulfamic acid 6-sulfamoyloxy-hexyl ester DMT3U2D MI TTANPDJ DMT3U2D MN Carbonic anhydrase II (CA-II) DMT3U2D MT DTT DMT3U2D MA Inhibitor DMT3U2D RN Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, and IX with bis-sulfamates. Bioorg Med Chem Lett. 2005 Feb 1;15(3):579-84. DMT3U2D RU https://pubmed.ncbi.nlm.nih.gov/15664816 DMT3U2D DI DMT3U2D DMT3U2D DN Sulfamic acid 6-sulfamoyloxy-hexyl ester DMT3U2D MI TT2LVK8 DMT3U2D MN Carbonic anhydrase IX (CA-IX) DMT3U2D MT DTT DMT3U2D MA Inhibitor DMT3U2D RN Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, and IX with bis-sulfamates. Bioorg Med Chem Lett. 2005 Feb 1;15(3):579-84. DMT3U2D RU https://pubmed.ncbi.nlm.nih.gov/15664816 DMVWEN3 DI DMVWEN3 DMVWEN3 DN Sulfamic acid 7-sulfamoyloxy-heptyl ester DMVWEN3 MI TTHQPL7 DMVWEN3 MN Carbonic anhydrase I (CA-I) DMVWEN3 MT DTT DMVWEN3 MA Inhibitor DMVWEN3 RN Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, and IX with bis-sulfamates. Bioorg Med Chem Lett. 2005 Feb 1;15(3):579-84. DMVWEN3 RU https://pubmed.ncbi.nlm.nih.gov/15664816 DMVWEN3 DI DMVWEN3 DMVWEN3 DN Sulfamic acid 7-sulfamoyloxy-heptyl ester DMVWEN3 MI TTANPDJ DMVWEN3 MN Carbonic anhydrase II (CA-II) DMVWEN3 MT DTT DMVWEN3 MA Inhibitor DMVWEN3 RN Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, and IX with bis-sulfamates. Bioorg Med Chem Lett. 2005 Feb 1;15(3):579-84. DMVWEN3 RU https://pubmed.ncbi.nlm.nih.gov/15664816 DMVWEN3 DI DMVWEN3 DMVWEN3 DN Sulfamic acid 7-sulfamoyloxy-heptyl ester DMVWEN3 MI TT2LVK8 DMVWEN3 MN Carbonic anhydrase IX (CA-IX) DMVWEN3 MT DTT DMVWEN3 MA Inhibitor DMVWEN3 RN Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, and IX with bis-sulfamates. Bioorg Med Chem Lett. 2005 Feb 1;15(3):579-84. DMVWEN3 RU https://pubmed.ncbi.nlm.nih.gov/15664816 DMFVQYI DI DMFVQYI DMFVQYI DN Sulfamic acid benzo[1,3]dioxol-2-ylmethyl ester DMFVQYI MI TTANPDJ DMFVQYI MN Carbonic anhydrase II (CA-II) DMFVQYI MT DTT DMFVQYI MA Inhibitor DMFVQYI RN Comparison of sulfamate and sulfamide groups for the inhibition of carbonic anhydrase-II by using topiramate as a structural platform. J Med Chem. 2005 Mar 24;48(6):1941-7. DMFVQYI RU https://pubmed.ncbi.nlm.nih.gov/15771438 DMN0Q71 DI DMN0Q71 DMN0Q71 DN Sulfamic acid chroman-2-ylmethyl ester DMN0Q71 MI TTANPDJ DMN0Q71 MN Carbonic anhydrase II (CA-II) DMN0Q71 MT DTT DMN0Q71 MA Inhibitor DMN0Q71 RN Comparison of sulfamate and sulfamide groups for the inhibition of carbonic anhydrase-II by using topiramate as a structural platform. J Med Chem. 2005 Mar 24;48(6):1941-7. DMN0Q71 RU https://pubmed.ncbi.nlm.nih.gov/15771438 DMW0ZBF DI DMW0ZBF DMW0ZBF DN Sulfate DMW0ZBF MI DTVGOLN DMW0ZBF MN Anion exchange transporter (SLC26A6) DMW0ZBF MT DTP DMW0ZBF MA Substrate DMW0ZBF RN The Transporter Classification Database (TCDB): recent advances. Nucleic Acids Res. 2016 Jan 4;44(D1):D372-9. (ID: 2.A.53.2.7) DMW0ZBF RU http://www.tcdb.org/search/result.php?tc=2.A.53.2.7 DMW0ZBF DI DMW0ZBF DMW0ZBF DN Sulfate DMW0ZBF MI DTOTME4 DMW0ZBF MN Anion exchange transporter (SLC26A7) DMW0ZBF MT DTP DMW0ZBF MA Substrate DMW0ZBF RN The Transporter Classification Database (TCDB): recent advances. Nucleic Acids Res. 2016 Jan 4;44(D1):D372-9. (ID: 2.A.53.2.6) DMW0ZBF RU http://www.tcdb.org/search/result.php?tc=2.A.53.2.6 DMW0ZBF DI DMW0ZBF DMW0ZBF DN Sulfate DMW0ZBF MI TTHQPL7 DMW0ZBF MN Carbonic anhydrase I (CA-I) DMW0ZBF MT DTT DMW0ZBF MA Inhibitor DMW0ZBF RN Carbonic anhydrase inhibitors. Inhibition of the newly isolated murine isozyme XIII with anions. Bioorg Med Chem Lett. 2004 Nov 1;14(21):5435-9. DMW0ZBF RU https://pubmed.ncbi.nlm.nih.gov/15454240 DMW0ZBF DI DMW0ZBF DMW0ZBF DN Sulfate DMW0ZBF MI DTJYKDQ DMW0ZBF MN Mitochondrial dicarboxylate carrier (SLC25A10) DMW0ZBF MT DTP DMW0ZBF MA Substrate DMW0ZBF RN SLC25A10 biallelic mutations in intractable epileptic encephalopathy with complex I deficiency. Hum Mol Genet. 2018 Feb 1;27(3):499-504. DMW0ZBF RU http://www.ncbi.nlm.nih.gov/pubmed/29211846 DMW0ZBF DI DMW0ZBF DMW0ZBF DN Sulfate DMW0ZBF MI DTJZ7W2 DMW0ZBF MN Na(+)/sulfate cotransporter SUT-1 (SLC13A4) DMW0ZBF MT DTP DMW0ZBF MA Substrate DMW0ZBF RN Loss of the sulfate transporter Slc13a4 in placenta causes severe fetal abnormalities and death in mice. Cell Res. 2015 Nov;25(11):1273-6. DMW0ZBF RU http://www.ncbi.nlm.nih.gov/pubmed/26292834 DMW0ZBF DI DMW0ZBF DMW0ZBF DN Sulfate DMW0ZBF MI DTIZEMV DMW0ZBF MN Sodium/sulfate cotransporter 1 (SLC13A1) DMW0ZBF MT DTP DMW0ZBF MA Substrate DMW0ZBF RN Na+-sulfate cotransporter SLC13A1. Pflugers Arch. 2014 Jan;466(1):131-7. DMW0ZBF RU http://www.ncbi.nlm.nih.gov/pubmed/24193406 DMW0ZBF DI DMW0ZBF DMW0ZBF DN Sulfate DMW0ZBF MI DTJ785O DMW0ZBF MN Sulfate anion transporter 1 (SLC26A1) DMW0ZBF MT DTP DMW0ZBF MA Substrate DMW0ZBF RN Mutations in SLC26A1 Cause Nephrolithiasis. Am J Hum Genet. 2016 Jun 2;98(6):1228-1234. DMW0ZBF RU http://www.ncbi.nlm.nih.gov/pubmed/27210743 DMW0ZBF DI DMW0ZBF DMW0ZBF DN Sulfate DMW0ZBF MI DTFSLX5 DMW0ZBF MN Sulfate transporter (SLC26A2) DMW0ZBF MT DTP DMW0ZBF MA Substrate DMW0ZBF RN Regulated transport of sulfate and oxalate by SLC26A2/DTDST. Am J Physiol Cell Physiol. 2010 Jun;298(6):C1363-75. DMW0ZBF RU http://www.ncbi.nlm.nih.gov/pubmed/20219950 DMW0ZBF DI DMW0ZBF DMW0ZBF DN Sulfate DMW0ZBF MI DEDG68B DMW0ZBF MN Sulfurylase kinase 1 (PAPSS1) DMW0ZBF MT DME DMW0ZBF MA Metabolism DMW0ZBF RN Human 3'-phosphoadenosine 5'-phosphosulfate synthetase (isoform 1, brain): kinetic properties of the adenosine triphosphate sulfurylase and adenosine 5'-phosphosulfate kinase domains. Biochemistry. 2004 Apr 13;43(14):4356-65. DMW0ZBF RU https://www.ncbi.nlm.nih.gov/pubmed/?term=15065880 DM8KYUE DI DM8KYUE DM8KYUE DN SULFOARECOLINE DM8KYUE MI TTZ9SOR DM8KYUE MN Muscarinic acetylcholine receptor M1 (CHRM1) DM8KYUE MT DTT DM8KYUE MA Inhibitor DM8KYUE RN Heterocyclic muscarinic agonists. Synthesis and biological activity of some bicyclic sulfonium arecoline bioisosteres. J Med Chem. 1988 Jul;31(7):1312-6. DM8KYUE RU https://pubmed.ncbi.nlm.nih.gov/3385727 DM8KYUE DI DM8KYUE DM8KYUE DN SULFOARECOLINE DM8KYUE MI TTYEG6Q DM8KYUE MN Muscarinic acetylcholine receptor M2 (CHRM2) DM8KYUE MT DTT DM8KYUE MA Inhibitor DM8KYUE RN Heterocyclic muscarinic agonists. Synthesis and biological activity of some bicyclic sulfonium arecoline bioisosteres. J Med Chem. 1988 Jul;31(7):1312-6. DM8KYUE RU https://pubmed.ncbi.nlm.nih.gov/3385727 DM8KYUE DI DM8KYUE DM8KYUE DN SULFOARECOLINE DM8KYUE MI TTQ13Z5 DM8KYUE MN Muscarinic acetylcholine receptor M3 (CHRM3) DM8KYUE MT DTT DM8KYUE MA Inhibitor DM8KYUE RN Heterocyclic muscarinic agonists. Synthesis and biological activity of some bicyclic sulfonium arecoline bioisosteres. J Med Chem. 1988 Jul;31(7):1312-6. DM8KYUE RU https://pubmed.ncbi.nlm.nih.gov/3385727 DM8KYUE DI DM8KYUE DM8KYUE DN SULFOARECOLINE DM8KYUE MI TTQ3JTF DM8KYUE MN Muscarinic acetylcholine receptor M4 (CHRM4) DM8KYUE MT DTT DM8KYUE MA Inhibitor DM8KYUE RN Heterocyclic muscarinic agonists. Synthesis and biological activity of some bicyclic sulfonium arecoline bioisosteres. J Med Chem. 1988 Jul;31(7):1312-6. DM8KYUE RU https://pubmed.ncbi.nlm.nih.gov/3385727 DM8KYUE DI DM8KYUE DM8KYUE DN SULFOARECOLINE DM8KYUE MI TTH18TF DM8KYUE MN Muscarinic acetylcholine receptor M5 (CHRM5) DM8KYUE MT DTT DM8KYUE MA Inhibitor DM8KYUE RN Heterocyclic muscarinic agonists. Synthesis and biological activity of some bicyclic sulfonium arecoline bioisosteres. J Med Chem. 1988 Jul;31(7):1312-6. DM8KYUE RU https://pubmed.ncbi.nlm.nih.gov/3385727 DMU0BW9 DI DMU0BW9 DMU0BW9 DN sulfonamide-01 DMU0BW9 MI TTRLZHP DMU0BW9 MN cAMP-dependent chloride channel (CFTR) DMU0BW9 MT DTT DMU0BW9 MA Activator DMU0BW9 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 707). DMU0BW9 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=707 DMBG0H1 DI DMBG0H1 DMBG0H1 DN Sulfonylthioureas DMBG0H1 MI TTG140O DMBG0H1 MN Inward rectifier potassium channel Kir1.2 (KCNJ10) DMBG0H1 MT DTT DMBG0H1 MA Blocker DMBG0H1 RN Cardioselective K(ATP) channel blockers derived from a new series of m-anisamidoethylbenzenesulfonylthioureas. J Med Chem. 2001 Mar 29;44(7):1085-98. DMBG0H1 RU https://pubmed.ncbi.nlm.nih.gov/11297455 DMQY3L0 DI DMQY3L0 DMQY3L0 DN Sulforaphane DMQY3L0 MI TTH1ZOP DMQY3L0 MN Inactive rhomboid protein 2 (RHBDF2) DMQY3L0 MT DTT DMQY3L0 RN p63 is a key regulator of iRHOM2 signalling in the keratinocyte stress response.Nat Commun. 2018 Mar 9;9(1):1021. DMQY3L0 RU https://pubmed.ncbi.nlm.nih.gov/29523849 DMYPM2D DI DMYPM2D DMYPM2D DN SULFURETIN DMYPM2D MI TTL53M6 DMYPM2D MN Induced myeloid leukemia cell differentiation protein Mcl-1 (MCL1) DMYPM2D MT DTT DMYPM2D MA Inhibitor DMYPM2D RN In silico identification and biochemical evaluation of novel inhibitors of NRH:quinone oxidoreductase 2 (NQO2). Bioorg Med Chem Lett. 2010 Dec 15;20(24):7331-6. DMYPM2D RU https://pubmed.ncbi.nlm.nih.gov/21074425 DMTEU0L DI DMTEU0L DMTEU0L DN Sul-Pro-Phe-N-MeHis-LVA-Ile-Amp DMTEU0L MI TTB2MXP DMTEU0L MN Angiotensinogenase renin (REN) DMTEU0L MT DTT DMTEU0L MA Inhibitor DMTEU0L RN Renin inhibitory peptides. Incorporation of polar, hydrophilic end groups into an active renin inhibitory peptide template and their evaluation in ... J Med Chem. 1991 Feb;34(2):633-42. DMTEU0L RU https://pubmed.ncbi.nlm.nih.gov/1995887 DMQB2CN DI DMQB2CN DMQB2CN DN Sul-Pro-Phe-N-MeHis-LVA-Ile-Amp-(O) DMQB2CN MI TTB2MXP DMQB2CN MN Angiotensinogenase renin (REN) DMQB2CN MT DTT DMQB2CN MA Inhibitor DMQB2CN RN Renin inhibitory peptides. Incorporation of polar, hydrophilic end groups into an active renin inhibitory peptide template and their evaluation in ... J Med Chem. 1991 Feb;34(2):633-42. DMQB2CN RU https://pubmed.ncbi.nlm.nih.gov/1995887 DM26KQG DI DM26KQG DM26KQG DN SUN-C8257 DM26KQG MI TT8VUE0 DM26KQG MN Chymase (CYM) DM26KQG MT DTT DM26KQG MA Inhibitor DM26KQG RN Chymase inhibitor ameliorates eosinophilia in mice infected with Nippostrongylus brasiliensis. Int Arch Allergy Immunol. 2002 Jul;128(3):235-9. DM26KQG RU https://pubmed.ncbi.nlm.nih.gov/12119506 DMVZWCI DI DMVZWCI DMVZWCI DN super cinnamaldehyde DMVZWCI MI TTELV3W DMVZWCI MN Transformation-sensitive protein p120 (TRPA1) DMVZWCI MT DTT DMVZWCI MA Activator DMVZWCI RN Noxious compounds activate TRPA1 ion channels through covalent modification of cysteines. Nature. 2007 Feb 1;445(7127):541-5. DMVZWCI RU https://pubmed.ncbi.nlm.nih.gov/17237762 DMN4IW5 DI DMN4IW5 DMN4IW5 DN Suramin DMN4IW5 MI TTV1095 DMN4IW5 MN COVID-19 RNA-directed RNA polymerase (RdRp) DMN4IW5 MT DTT DMN4IW5 MA Inhibitor DMN4IW5 RN Suramin, Penciclovir and Anidulafungin bind nsp12, which governs the RNA-dependent-RNA polymerase activity of SARS-CoV-2, with higher interaction energy than Remdesivir, indicating potential in the treatment of Covid-19 infection. April.21.2020. Doi: 10.31219/osf.io/urxwh DMN4IW5 RU https://osf.io/urxwh DMQ5GMV DI DMQ5GMV DMQ5GMV DN SUVN-1004028 DMQ5GMV MI TT07C3Y DMQ5GMV MN 5-HT 4 receptor (HTR4) DMQ5GMV MT DTT DMQ5GMV MA Agonist DMQ5GMV RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 9). DMQ5GMV RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=9 DMT8PKC DI DMT8PKC DMT8PKC DN SUVN-501 DMT8PKC MI TTJS8PY DMT8PKC MN 5-HT 6 receptor (HTR6) DMT8PKC MT DTT DMT8PKC MA Antagonist DMT8PKC RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 11). DMT8PKC RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=11 DMZCKDH DI DMZCKDH DMZCKDH DN SUVN-504 DMZCKDH MI TTJS8PY DMZCKDH MN 5-HT 6 receptor (HTR6) DMZCKDH MT DTT DMZCKDH MA Antagonist DMZCKDH RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 11). DMZCKDH RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=11 DM2UMK8 DI DM2UMK8 DM2UMK8 DN SUVN-507 DM2UMK8 MI TTJS8PY DM2UMK8 MN 5-HT 6 receptor (HTR6) DM2UMK8 MT DTT DM2UMK8 MA Antagonist DM2UMK8 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 11). DM2UMK8 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=11 DMVDHBT DI DMVDHBT DMVDHBT DN SUVN-G1031 DMVDHBT MI TT9JNIC DMVDHBT MN Histamine H3 receptor (H3R) DMVDHBT MT DTT DMVDHBT MA Antagonist DMVDHBT RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 264). DMVDHBT RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=264 DMZGX48 DI DMZGX48 DMZGX48 DN SX-517 DMZGX48 MI TT30C9G DMZGX48 MN C-X-C chemokine receptor type 2 (CXCR2) DMZGX48 MT DTT DMZGX48 MA Antagonist DMZGX48 RN Discovery of 2-[5-(4-Fluorophenylcarbamoyl)pyridin-2-ylsulfanylmethyl]phenylboronic Acid (SX-517): Noncompetitive Boronic Acid Antagonist of CXCR1 and CXCR2. J Med Chem. 2014 Oct 23;57(20):8378-97. DMZGX48 RU https://pubmed.ncbi.nlm.nih.gov/25254640 DMEA36L DI DMEA36L DMEA36L DN SX-ARPC DMEA36L MI TTS64P2 DMEA36L MN Androgen receptor (AR) DMEA36L MT DTT DMEA36L MA Antagonist DMEA36L RN Clinical pipeline report, company report or official report of Progenics Pharmaceuticals Serometrix. DMEA36L RU http://www.serometrix.com/pipeline.html DMT53U6 DI DMT53U6 DMT53U6 DN SX-GLP1 DMT53U6 MI TTVIMDE DMT53U6 MN Glucagon-like peptide 1 receptor (GLP1R) DMT53U6 MT DTT DMT53U6 MA Agonist DMT53U6 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 249). DMT53U6 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=249 DMJGZ79 DI DMJGZ79 DMJGZ79 DN SX-MTR1 DMJGZ79 MI TTCJG29 DMJGZ79 MN Serine/threonine-protein kinase mTOR (mTOR) DMJGZ79 MT DTT DMJGZ79 MA Modulator DMJGZ79 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2109). DMJGZ79 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2109 DM7YB08 DI DM7YB08 DM7YB08 DN SYL-040003 DM7YB08 MI TTZHA0O DM7YB08 MN Carbonic anhydrase IV (CA-IV) DM7YB08 MT DTT DM7YB08 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2599). DM7YB08 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2599 DMKIDRY DI DMKIDRY DMKIDRY DN SYM-011 DMKIDRY MI TTGKNB4 DMKIDRY MN Epidermal growth factor receptor (EGFR) DMKIDRY MT DTT DMKIDRY MA Modulator DMKIDRY RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1797). DMKIDRY RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1797 DMKIDRY DI DMKIDRY DMKIDRY DN SYM-011 DMKIDRY MI TTDC8N2 DMKIDRY MN Erbb3 tyrosine kinase receptor (Erbb-3) DMKIDRY MT DTT DMKIDRY MA Modulator DMKIDRY RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1798). DMKIDRY RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1798 DM30WDL DI DM30WDL DM30WDL DN SYM2081 DM30WDL MI TT8WRDA DM30WDL MN Excitatory amino acid transporter 1 (SLC1A3) DM30WDL MT DTT DM30WDL MA Modulator DM30WDL RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 868). DM30WDL RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=868 DM30WDL DI DM30WDL DM30WDL DN SYM2081 DM30WDL MI TT2F078 DM30WDL MN Excitatory amino acid transporter 2 (SLC1A2) DM30WDL MT DTT DM30WDL MA Inhibitor DM30WDL RN Contrasting modes of action of methylglutamate derivatives on the excitatory amino acid transporters, EAAT1 and EAAT2. Mol Pharmacol. 1997 May;51(5):809-15. DM30WDL RU https://pubmed.ncbi.nlm.nih.gov/9145919 DM30WDL DI DM30WDL DM30WDL DN SYM2081 DM30WDL MI TT0MYE2 DM30WDL MN Glutamate receptor ionotropic kainate 1 (GRIK1) DM30WDL MT DTT DM30WDL MA Agonist DM30WDL RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 450). DM30WDL RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=450 DM30WDL DI DM30WDL DM30WDL DN SYM2081 DM30WDL MI TT0K5RG DM30WDL MN Glutamate receptor ionotropic kainate 2 (GRIK2) DM30WDL MT DTT DM30WDL MA Agonist DM30WDL RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 451). DM30WDL RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=451 DM30WDL DI DM30WDL DM30WDL DN SYM2081 DM30WDL MI TTNP6O2 DM30WDL MN Glutamate receptor ionotropic kainate 3 (GluK3) DM30WDL MT DTT DM30WDL MA Agonist DM30WDL RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 452). DM30WDL RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=452 DM30WDL DI DM30WDL DM30WDL DN SYM2081 DM30WDL MI TTQV6BO DM30WDL MN Glutamate receptor ionotropic kainate 4 (GluK4) DM30WDL MT DTT DM30WDL MA Agonist DM30WDL RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 453). DM30WDL RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=453 DM30WDL DI DM30WDL DM30WDL DN SYM2081 DM30WDL MI TTO6LI7 DM30WDL MN Glutamate receptor ionotropic kainate 5 (GRIK5) DM30WDL MT DTT DM30WDL MA Agonist DM30WDL RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 454). DM30WDL RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=454 DM28TXP DI DM28TXP DM28TXP DN SYMBIOPOLYOL DM28TXP MI TTHCEF6 DM28TXP MN VCAM-1 messenger RNA (VCAM1 mRNA) DM28TXP MT DTT DM28TXP MA Inhibitor DM28TXP RN Symbiopolyol, a VCAM-1 inhibitor from a symbiotic dinoflagellate of the jellyfish Mastigias papua. J Nat Prod. 2010 Jul 23;73(7):1318-22. DM28TXP RU https://pubmed.ncbi.nlm.nih.gov/20557071 DMYTEXB DI DMYTEXB DMYTEXB DN Syn-1020 DMYTEXB MI TTNT7K8 DMYTEXB MN Nociceptin receptor (OPRL1) DMYTEXB MT DTT DMYTEXB MA Agonist DMYTEXB RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 320). DMYTEXB RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=320 DMFNR75 DI DMFNR75 DMFNR75 DN SYN-1327 DMFNR75 MI TTKLPHO DMFNR75 MN Neonatal Fc receptor (FCGRT) DMFNR75 MT DTT DMFNR75 MA Inhibitor DMFNR75 RN Structure-activity relationships of a peptide inhibitor of the human FcRn:human IgG interaction. Bioorg Med Chem. 2008 Jun 15;16(12):6394-405. DMFNR75 RU https://pubmed.ncbi.nlm.nih.gov/18501614 DMM5PVL DI DMM5PVL DMM5PVL DN syn-BrP-LPA DMM5PVL MI TTQ6S1K DMM5PVL MN Lysophosphatidic acid receptor 1 (LPAR1) DMM5PVL MT DTT DMM5PVL MA Antagonist DMM5PVL RN Dual activity lysophosphatidic acid receptor pan-antagonist/autotaxin inhibitor reduces breast cancer cell migration in vitro and causes tumor regression in vivo. Cancer Res. 2009 Jul 1;69(13):5441-9. DMM5PVL RU https://pubmed.ncbi.nlm.nih.gov/19509223 DM802V7 DI DM802V7 DM802V7 DN Syringic Acid DM802V7 MI TTUNARX DM802V7 MN Carbonic anhydrase (CA) DM802V7 MT DTT DM802V7 MA Inhibitor DM802V7 RN Carbonic anhydrase inhibitors. Inhibition of mammalian isoforms I-XIV with a series of natural product polyphenols and phenolic acids. Bioorg Med Chem. 2010 Mar 15;18(6):2159-2164. DM802V7 RU https://pubmed.ncbi.nlm.nih.gov/20185318 DM802V7 DI DM802V7 DM802V7 DN Syringic Acid DM802V7 MI TTHQPL7 DM802V7 MN Carbonic anhydrase I (CA-I) DM802V7 MT DTT DM802V7 MA Inhibitor DM802V7 RN Carbonic anhydrase inhibitors. Inhibition of mammalian isoforms I-XIV with a series of natural product polyphenols and phenolic acids. Bioorg Med Chem. 2010 Mar 15;18(6):2159-2164. DM802V7 RU https://pubmed.ncbi.nlm.nih.gov/20185318 DM802V7 DI DM802V7 DM802V7 DN Syringic Acid DM802V7 MI TTANPDJ DM802V7 MN Carbonic anhydrase II (CA-II) DM802V7 MT DTT DM802V7 MA Inhibitor DM802V7 RN Carbonic anhydrase inhibitors. Inhibition of mammalian isoforms I-XIV with a series of natural product polyphenols and phenolic acids. Bioorg Med Chem. 2010 Mar 15;18(6):2159-2164. DM802V7 RU https://pubmed.ncbi.nlm.nih.gov/20185318 DM802V7 DI DM802V7 DM802V7 DN Syringic Acid DM802V7 MI TTZHA0O DM802V7 MN Carbonic anhydrase IV (CA-IV) DM802V7 MT DTT DM802V7 MA Inhibitor DM802V7 RN Carbonic anhydrase inhibitors. Inhibition of mammalian isoforms I-XIV with a series of natural product polyphenols and phenolic acids. Bioorg Med Chem. 2010 Mar 15;18(6):2159-2164. DM802V7 RU https://pubmed.ncbi.nlm.nih.gov/20185318 DM802V7 DI DM802V7 DM802V7 DN Syringic Acid DM802V7 MI TT2LVK8 DM802V7 MN Carbonic anhydrase IX (CA-IX) DM802V7 MT DTT DM802V7 MA Inhibitor DM802V7 RN Carbonic anhydrase inhibitors. Inhibition of mammalian isoforms I-XIV with a series of natural product polyphenols and phenolic acids. Bioorg Med Chem. 2010 Mar 15;18(6):2159-2164. DM802V7 RU https://pubmed.ncbi.nlm.nih.gov/20185318 DM802V7 DI DM802V7 DM802V7 DN Syringic Acid DM802V7 MI TTCFSPE DM802V7 MN Carbonic anhydrase VI (CA-VI) DM802V7 MT DTT DM802V7 MA Inhibitor DM802V7 RN Carbonic anhydrase inhibitors. Inhibition of mammalian isoforms I-XIV with a series of natural product polyphenols and phenolic acids. Bioorg Med Chem. 2010 Mar 15;18(6):2159-2164. DM802V7 RU https://pubmed.ncbi.nlm.nih.gov/20185318 DM802V7 DI DM802V7 DM802V7 DN Syringic Acid DM802V7 MI TTSYM0R DM802V7 MN Carbonic anhydrase XII (CA-XII) DM802V7 MT DTT DM802V7 MA Inhibitor DM802V7 RN Carbonic anhydrase inhibitors. Inhibition of mammalian isoforms I-XIV with a series of natural product polyphenols and phenolic acids. Bioorg Med Chem. 2010 Mar 15;18(6):2159-2164. DM802V7 RU https://pubmed.ncbi.nlm.nih.gov/20185318 DM802V7 DI DM802V7 DM802V7 DN Syringic Acid DM802V7 MI TTEYTKG DM802V7 MN Carbonic anhydrase XIV (CA-XIV) DM802V7 MT DTT DM802V7 MA Inhibitor DM802V7 RN Carbonic anhydrase inhibitors. Inhibition of mammalian isoforms I-XIV with a series of natural product polyphenols and phenolic acids. Bioorg Med Chem. 2010 Mar 15;18(6):2159-2164. DM802V7 RU https://pubmed.ncbi.nlm.nih.gov/20185318 DM8L6ZF DI DM8L6ZF DM8L6ZF DN SZ(+)-(S)-202-791 DM8L6ZF MI TT94HRF DM8L6ZF MN Voltage-gated calcium channel alpha Cav1.1 (CACNA1S) DM8L6ZF MT DTT DM8L6ZF MA Activator DM8L6ZF RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 528). DM8L6ZF RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=528 DM8L6ZF DI DM8L6ZF DM8L6ZF DN SZ(+)-(S)-202-791 DM8L6ZF MI TTZIFHC DM8L6ZF MN Voltage-gated calcium channel alpha Cav1.2 (CACNA1C) DM8L6ZF MT DTT DM8L6ZF MA Activator DM8L6ZF RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 529). DM8L6ZF RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=529 DMTKSVO DI DMTKSVO DMTKSVO DN T0070907 DMTKSVO MI TTT2SVW DMTKSVO MN PPAR-gamma messenger RNA (PPARG mRNA) DMTKSVO MT DTT DMTKSVO MA Antagonist DMTKSVO RN T0070907, a selective ligand for peroxisome proliferator-activated receptor gamma, functions as an antagonist of biochemical and cellular activities. J Biol Chem. 2002 May 31;277(22):19649-57. DMTKSVO RU https://pubmed.ncbi.nlm.nih.gov/11877444 DMZE9TW DI DMZE9TW DMZE9TW DN T0156 DMZE9TW MI TTJ0IQB DMZE9TW MN Phosphodiesterase 5A (PDE5A) DMZE9TW MT DTT DMZE9TW MA Inhibitor DMZE9TW RN Enzymological and pharmacological profile of T-0156, a potent and selective phosphodiesterase type 5 inhibitor. Eur J Pharmacol. 2002 Dec 5;456(1-3):91-8. DMZE9TW RU https://pubmed.ncbi.nlm.nih.gov/12450574 DMSVLXQ DI DMSVLXQ DMSVLXQ DN T-0509 DMSVLXQ MI TTMXGCW DMSVLXQ MN Adrenergic receptor beta-3 (ADRB3) DMSVLXQ MT DTT DMSVLXQ MA Agonist DMSVLXQ RN Molecular characterization of pharmacological properties of T-0509 for beta-adrenoceptors. Eur J Pharmacol. 1996 Nov 21;315(3):363-7. DMSVLXQ RU https://pubmed.ncbi.nlm.nih.gov/8982677 DMZQVDI DI DMZQVDI DMZQVDI DN T0901317 DMZQVDI MI TTM1EQF DMZQVDI MN Oxysterols receptor LXR (NR1H) DMZQVDI MT DTT DMZQVDI MA Binder DMZQVDI RN The LXR ligand T0901317 induces severe lipogenesis in the db/db diabetic mouse. J Lipid Res. 2003 Nov;44(11):2039-48. DMZQVDI RU https://pubmed.ncbi.nlm.nih.gov/12923232 DMGPQ0Y DI DMGPQ0Y DMGPQ0Y DN T-1105 DMGPQ0Y MI TTSUKYD DMGPQ0Y MN Virus RNA-dependent RNA polymerase (Viru RdRP) DMGPQ0Y MT DTT DMGPQ0Y MA Inhibitor DMGPQ0Y RN Activity of T-705 in a hamster model of yellow fever virus infection in comparison with that of a chemically related compound, T-1106. Antimicrob Agents Chemother. 2009 Jan;53(1):202-9. DMGPQ0Y RU https://pubmed.ncbi.nlm.nih.gov/18955536 DMPA2E9 DI DMPA2E9 DMPA2E9 DN T-1106 DMPA2E9 MI TTSUKYD DMPA2E9 MN Virus RNA-dependent RNA polymerase (Viru RdRP) DMPA2E9 MT DTT DMPA2E9 MA Inhibitor DMPA2E9 RN Activity of T-705 in a hamster model of yellow fever virus infection in comparison with that of a chemically related compound, T-1106. Antimicrob Agents Chemother. 2009 Jan;53(1):202-9. DMPA2E9 RU https://pubmed.ncbi.nlm.nih.gov/18955536 DMSA3U4 DI DMSA3U4 DMSA3U4 DN T1117 DMSA3U4 MI TTNET8J DMSA3U4 MN G-protein coupled receptor 55 (GPR55) DMSA3U4 MT DTT DMSA3U4 MA Agonist DMSA3U4 RN Fluorescent ligand binding reveals heterogeneous distribution of adrenoceptors and 'cannabinoid-like' receptors in small arteries. Br J Pharmacol. 2010 Feb;159(4):787-96. DMSA3U4 RU https://pubmed.ncbi.nlm.nih.gov/20136833 DMVRJEL DI DMVRJEL DMVRJEL DN T13 DMVRJEL MI TTE2YJR DMVRJEL MN Lysophosphatidate-3 receptor (LPAR3) DMVRJEL MT DTT DMVRJEL MA Agonist DMVRJEL RN LPA and its analogs-attractive tools for elucidation of LPA biology and drug development. Curr Med Chem. 2008;15(21):2122-31. DMVRJEL RU https://pubmed.ncbi.nlm.nih.gov/18781939 DMVRJEL DI DMVRJEL DMVRJEL DN T13 DMVRJEL MI TTQ6S1K DMVRJEL MN Lysophosphatidic acid receptor 1 (LPAR1) DMVRJEL MT DTT DMVRJEL MA Agonist DMVRJEL RN Pharmacological tools for lysophospholipid GPCRs: development of agonists and antagonists for LPA and S1P receptors. Acta Pharmacol Sin. 2010 Sep;31(9):1213-22. DMVRJEL RU https://pubmed.ncbi.nlm.nih.gov/20729877 DM6HZVC DI DM6HZVC DM6HZVC DN T134 DM6HZVC MI TTBID49 DM6HZVC MN C-X-C chemokine receptor type 4 (CXCR4) DM6HZVC MT DTT DM6HZVC MA Antagonist DM6HZVC RN A low-molecular-weight inhibitor against the chemokine receptor CXCR4: a strong anti-HIV peptide T140. Biochem Biophys Res Commun. 1998 Dec 30;253(3):877-82. DM6HZVC RU https://pubmed.ncbi.nlm.nih.gov/9918823 DMIHBC5 DI DMIHBC5 DMIHBC5 DN T140 DMIHBC5 MI TTBID49 DMIHBC5 MN C-X-C chemokine receptor type 4 (CXCR4) DMIHBC5 MT DTT DMIHBC5 MA Antagonist DMIHBC5 RN A low-molecular-weight inhibitor against the chemokine receptor CXCR4: a strong anti-HIV peptide T140. Biochem Biophys Res Commun. 1998 Dec 30;253(3):877-82. DMIHBC5 RU https://pubmed.ncbi.nlm.nih.gov/9918823 DMBIH8A DI DMBIH8A DMBIH8A DN T22 DMBIH8A MI TTBID49 DMBIH8A MN C-X-C chemokine receptor type 4 (CXCR4) DMBIH8A MT DTT DMBIH8A MA Antagonist DMBIH8A RN A low-molecular-weight inhibitor against the chemokine receptor CXCR4: a strong anti-HIV peptide T140. Biochem Biophys Res Commun. 1998 Dec 30;253(3):877-82. DMBIH8A RU https://pubmed.ncbi.nlm.nih.gov/9918823 DMCWE90 DI DMCWE90 DMCWE90 DN T2328 DMCWE90 MI TTZPO1L DMCWE90 MN Substance-P receptor (TACR1) DMCWE90 MT DTT DMCWE90 MA Antagonist DMCWE90 RN Pharmacological characterization of T-2328, 2-fluoro-4'-methoxy-3'-[[[(2S,3S)-2-phenyl-3-piperidinyl]amino]methyl]-[1,1'-biphenyl]-4-carbonitrile d... J Pharmacol Sci. 2008 Jan;106(1):121-7. DMCWE90 RU https://pubmed.ncbi.nlm.nih.gov/18187929 DMFKQ1W DI DMFKQ1W DMFKQ1W DN T-98475 DMFKQ1W MI TT8R70G DMFKQ1W MN Gonadotropin-releasing hormone receptor (GNRHR) DMFKQ1W MT DTT DMFKQ1W MA Inhibitor DMFKQ1W RN Non-peptide gonadotropin-releasing hormone receptor antagonists. J Med Chem. 2008 Jun 26;51(12):3331-48. DMFKQ1W RU https://pubmed.ncbi.nlm.nih.gov/18419112 DME2PFQ DI DME2PFQ DME2PFQ DN TA-106 DME2PFQ MI TTA0P7K DME2PFQ MN Complement factor B (CFB) DME2PFQ MT DTT DME2PFQ RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2339). DME2PFQ RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2339 DMP2016 DI DMP2016 DMP2016 DN TA1-RTA DMP2016 MI TT6EO5L DMP2016 MN Erbb2 tyrosine kinase receptor (HER2) DMP2016 MT DTT DMP2016 MA Binder DMP2016 RN Synergistic interaction between anti-p185HER-2 ricin A chain immunotoxins and radionuclide conjugates for inhibiting growth of ovarian and breast cancer cells that overexpress HER-2. Clin Cancer Res.2000 Aug;6(8):3334-41. DMP2016 RU https://pubmed.ncbi.nlm.nih.gov/10955821 DMOWHER DI DMOWHER DMOWHER DN TACRINE(8)-4-AMINOQUINOLINE DMOWHER MI TT1RS9F DMOWHER MN Acetylcholinesterase (AChE) DMOWHER MT DTT DMOWHER MA Inhibitor DMOWHER RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DMOWHER RU https://pubmed.ncbi.nlm.nih.gov/10592235 DMCIEQO DI DMCIEQO DMCIEQO DN TAD DMCIEQO MI TTL7C8Q DMCIEQO MN Inosine-5'-monophosphate dehydrogenase 1 (IMPDH1) DMCIEQO MT DTT DMCIEQO MA Inhibitor DMCIEQO RN Crystal structure of a ternary complex of Tritrichomonas foetus inosine 5'-monophosphate dehydrogenase: NAD+ orients the active site loop for catalysis. Biochemistry. 2002 Nov 5;41(44):13309-17. DMCIEQO RU https://pubmed.ncbi.nlm.nih.gov/12403633 DM3B8R1 DI DM3B8R1 DM3B8R1 DN Tagetitoxin DM3B8R1 MI TTS31JH DM3B8R1 MN Staphylococcus Plastid RNA polymerase beta (Stap-coc rpoB) DM3B8R1 MT DTT DM3B8R1 MA Inhibitor DM3B8R1 RN Synthesis of the bicyclic core of tagetitoxin. Chem Commun (Camb). 2006 Mar 21;(11):1197-9. DM3B8R1 RU https://pubmed.ncbi.nlm.nih.gov/16518489 DM2RN0S DI DM2RN0S DM2RN0S DN tagitinin A DM2RN0S MI TTT2SVW DM2RN0S MN PPAR-gamma messenger RNA (PPARG mRNA) DM2RN0S MT DTT DM2RN0S MA Agonist DM2RN0S RN Sesquiterpene lactones from Tithonia diversifolia act as peroxisome proliferator-activated receptor agonists. Bioorg Med Chem Lett. 2012 Apr 15;22(8):2954-8. DM2RN0S RU https://pubmed.ncbi.nlm.nih.gov/22424975 DMLOAZB DI DMLOAZB DMLOAZB DN TAK-075 DMLOAZB MI TTBUYHA DMLOAZB MN Extracellular calcium-sensing receptor (CASR) DMLOAZB MT DTT DMLOAZB MA Antagonist DMLOAZB RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 54). DMLOAZB RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=54 DMW24JP DI DMW24JP DMW24JP DN TALAROFLAVONE DMW24JP MI TTIU7X1 DMW24JP MN Herpes simplex virus DNA polymerase UL30 (HSV UL30) DMW24JP MT DTT DMW24JP MA Inhibitor DMW24JP RN 1-deoxyrubralactone, a novel specific inhibitor of families X and Y of eukaryotic DNA polymerases from a fungal strain derived from sea algae. Bioorg Med Chem. 2008 Mar 15;16(6):2939-44. DMW24JP RU https://pubmed.ncbi.nlm.nih.gov/18178092 DMRTD16 DI DMRTD16 DMRTD16 DN Talinolol DMRTD16 MI DE4LYSA DMRTD16 MN Cytochrome P450 3A4 (CYP3A4) DMRTD16 MT DME DMRTD16 MA Metabolism DMRTD16 RN Stereoselective disposition of talinolol in man. J Pharm Sci. 2002 Feb;91(2):303-11. DMRTD16 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=11835190 DMRTD16 DI DMRTD16 DMRTD16 DN Talinolol DMRTD16 MI DTFI42L DMRTD16 MN Multidrug resistance-associated protein 2 (ABCC2) DMRTD16 MT DTP DMRTD16 MA Substrate DMRTD16 RN FDA Drug Development and Drug Interactions DMRTD16 RU https://www.fda.gov/drugs/developmentapprovalprocess/developmentresources/druginteractionslabeling/ucm093664.htm#table3-2 DMRTD16 DI DMRTD16 DMRTD16 DN Talinolol DMRTD16 MI DTE2B1D DMRTD16 MN Organic anion transporting polypeptide 1A2 (SLCO1A2) DMRTD16 MT DTP DMRTD16 MA Substrate DMRTD16 RN Concentration-dependent effect of naringin on intestinal absorption of beta(1)-adrenoceptor antagonist talinolol mediated by p-glycoprotein and organic anion transporting polypeptide (Oatp). Pharm Res. 2009 Mar;26(3):560-7. DMRTD16 RU http://www.ncbi.nlm.nih.gov/pubmed/19002566 DMRTD16 DI DMRTD16 DMRTD16 DN Talinolol DMRTD16 MI DTPFTEQ DMRTD16 MN Organic anion transporting polypeptide 2B1 (SLCO2B1) DMRTD16 MT DTP DMRTD16 MA Substrate DMRTD16 RN Species difference in the effect of grapefruit juice on intestinal absorption of talinolol between human and rat. J Pharmacol Exp Ther. 2010 Jan;332(1):181-9. DMRTD16 RU http://www.ncbi.nlm.nih.gov/pubmed/19779132 DMRTD16 DI DMRTD16 DMRTD16 DN Talinolol DMRTD16 MI DTUGYRD DMRTD16 MN P-glycoprotein 1 (ABCB1) DMRTD16 MT DTP DMRTD16 MA Substrate DMRTD16 RN Grapefruit juice-drug interactions: Grapefruit juice and its components inhibit P-glycoprotein (ABCB1) mediated transport of talinolol in Caco-2 cells. J Pharm Sci. 2007 Oct;96(10):2808-17. DMRTD16 RU http://www.ncbi.nlm.nih.gov/pubmed/17542018 DMMTSL2 DI DMMTSL2 DMMTSL2 DN Talmapimod DMMTSL2 MI TTQBR95 DMMTSL2 MN Stress-activated protein kinase 2a (p38 alpha) DMMTSL2 MT DTT DMMTSL2 MA Modulator DMMTSL2 RN Mitogen-activated protein kinases in innate immunity.Nat Rev Immunol.2013 Sep;13(9):679-92. DMMTSL2 RU https://www.ncbi.nlm.nih.gov/pubmed/23954936 DM26SE7 DI DM26SE7 DM26SE7 DN TAM-67 DM26SE7 MI TTN3GBV DM26SE7 MN Transcription factor AP-1 (JUN) DM26SE7 MT DTT DM26SE7 MA Inhibitor DM26SE7 RN AP-1 blockade inhibits the growth of normal and malignant breast cells. Oncogene. 2001 May 17;20(22):2771-80. DM26SE7 RU https://pubmed.ncbi.nlm.nih.gov/11420689 DM0EP51 DI DM0EP51 DM0EP51 DN TAMARIXETIN DM0EP51 MI TTI84H7 DM0EP51 MN Cytochrome P450 1B1 (CYP1B1) DM0EP51 MT DTT DM0EP51 MA Inhibitor DM0EP51 RN Selective inhibition of methoxyflavonoids on human CYP1B1 activity. Bioorg Med Chem. 2010 Sep 1;18(17):6310-5. DM0EP51 RU https://pubmed.ncbi.nlm.nih.gov/20696580 DM17JFO DI DM17JFO DM17JFO DN Tamarixetin 3-glucoside-7-sulfate DM17JFO MI TTFBNVI DM17JFO MN Aldose reductase (AKR1B1) DM17JFO MT DTT DM17JFO MA Inhibitor DM17JFO RN Effect of Polygonum hydropiper sulfated flavonoids on lens aldose reductase and related enzymes. J Nat Prod. 1996 Apr;59(4):443-5. DM17JFO RU https://pubmed.ncbi.nlm.nih.gov/8699190 DMBKL5O DI DMBKL5O DMBKL5O DN Tamoxifen butyl bromide DMBKL5O MI TTZAYWL DMBKL5O MN Estrogen receptor (ESR) DMBKL5O MT DTT DMBKL5O MA Inhibitor DMBKL5O RN Genomic action of permanently charged tamoxifen derivatives via estrogen receptor-alpha. Bioorg Med Chem. 2010 Aug 1;18(15):5593-601. DMBKL5O RU https://pubmed.ncbi.nlm.nih.gov/20621492 DM76BXY DI DM76BXY DM76BXY DN Tamoxifen ethyl bromide DM76BXY MI TTZAYWL DM76BXY MN Estrogen receptor (ESR) DM76BXY MT DTT DM76BXY MA Inhibitor DM76BXY RN Genomic action of permanently charged tamoxifen derivatives via estrogen receptor-alpha. Bioorg Med Chem. 2010 Aug 1;18(15):5593-601. DM76BXY RU https://pubmed.ncbi.nlm.nih.gov/20621492 DMBKWUZ DI DMBKWUZ DMBKWUZ DN Tamoxifen isopropyl bromide DMBKWUZ MI TTZAYWL DMBKWUZ MN Estrogen receptor (ESR) DMBKWUZ MT DTT DMBKWUZ MA Inhibitor DMBKWUZ RN Genomic action of permanently charged tamoxifen derivatives via estrogen receptor-alpha. Bioorg Med Chem. 2010 Aug 1;18(15):5593-601. DMBKWUZ RU https://pubmed.ncbi.nlm.nih.gov/20621492 DMQCW7V DI DMQCW7V DMQCW7V DN Tanaproget DMQCW7V MI TTUV8G9 DMQCW7V MN Progesterone receptor (PGR) DMQCW7V MT DTT DMQCW7V MA Inhibitor DMQCW7V RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DMQCW7V RU https://pubmed.ncbi.nlm.nih.gov/10592235 DM52WGH DI DM52WGH DM52WGH DN tannic acid DM52WGH MI TTOJI4S DM52WGH MN Calcium-dependent chloride channel anoctamin (ANO) DM52WGH MT DTT DM52WGH MA Blocker (channel blocker) DM52WGH RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 708). DM52WGH RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=708 DMTFHRI DI DMTFHRI DMTFHRI DN TANNIN DMTFHRI MI TTFJ8Q1 DMTFHRI MN Protein kinase C alpha (PRKCA) DMTFHRI MT DTT DMTFHRI MA Inhibitor DMTFHRI RN Tannins as selective inhibitors of protein kinase C, Bioorg. Med. Chem. Lett. 2(3):239-244 (1992). DMTFHRI RU http://www.sciencedirect.com/science/article/pii/S0960894X01810726 DMTFHRI DI DMTFHRI DMTFHRI DN TANNIN DMTFHRI MI TTYPXQF DMTFHRI MN Protein kinase C beta (PRKCB) DMTFHRI MT DTT DMTFHRI MA Inhibitor DMTFHRI RN Tannins as selective inhibitors of protein kinase C, Bioorg. Med. Chem. Lett. 2(3):239-244 (1992). DMTFHRI RU http://www.sciencedirect.com/science/article/pii/S0960894X01810726 DM07FBL DI DM07FBL DM07FBL DN TAS-203 DM07FBL MI TTZ97H5 DM07FBL MN Phosphodiesterase 4A (PDE4A) DM07FBL MT DTT DM07FBL MA Inhibitor DM07FBL RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1300). DM07FBL RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1300 DM07FBL DI DM07FBL DM07FBL DN TAS-203 DM07FBL MI TTVIAT9 DM07FBL MN Phosphodiesterase 4B (PDE4B) DM07FBL MT DTT DM07FBL MA Inhibitor DM07FBL RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1301). DM07FBL RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1301 DM07FBL DI DM07FBL DM07FBL DN TAS-203 DM07FBL MI TTSKMI8 DM07FBL MN Phosphodiesterase 4D (PDE4D) DM07FBL MT DTT DM07FBL MA Inhibitor DM07FBL RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1303). DM07FBL RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1303 DM9S5DV DI DM9S5DV DM9S5DV DN TASPINE DM9S5DV MI TT1RS9F DM9S5DV MN Acetylcholinesterase (AChE) DM9S5DV MT DTT DM9S5DV MA Inhibitor DM9S5DV RN Taspine: bioactivity-guided isolation and molecular ligand-target insight of a potent acetylcholinesterase inhibitor from Magnolia x soulangiana. J Nat Prod. 2006 Sep;69(9):1341-6. DM9S5DV RU https://pubmed.ncbi.nlm.nih.gov/16989531 DML01Y7 DI DML01Y7 DML01Y7 DN TAT-120 DML01Y7 MI TTCPLVN DML01Y7 MN MST-1 protein kinase (STK4) DML01Y7 MT DTT DML01Y7 MA Inhibitor DML01Y7 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2225). DML01Y7 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2225 DMVW7N3 DI DMVW7N3 DMVW7N3 DN Taurine DMVW7N3 MI DERA3OF DMVW7N3 MN Bile acid-CoA thioesterase (BAAT) DMVW7N3 MT DME DMVW7N3 MA Metabolism DMVW7N3 RN Bile acid coenzyme A: amino acid N-acyltransferase in the amino acid conjugation of bile acids. Methods Enzymol. 2005;400:374-94. DMVW7N3 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=16399361 DMVW7N3 DI DMVW7N3 DMVW7N3 DN Taurine DMVW7N3 MI TTZ8EM9 DMVW7N3 MN Glycine receptor (GlyR) DMVW7N3 MT DTT DMVW7N3 MA Agonist DMVW7N3 RN Identification of intracellular and extracellular domains mediating signal transduction in the inhibitory glycine receptor chloride channel. EMBO J. 1997 Jan 2;16(1):110-20. DMVW7N3 RU https://pubmed.ncbi.nlm.nih.gov/9009272 DMVW7N3 DI DMVW7N3 DMVW7N3 DN Taurine DMVW7N3 MI DTHWCVA DMVW7N3 MN Sodium- and chloride-dependent taurine transporter (SLC6A6) DMVW7N3 MT DTP DMVW7N3 MA Substrate DMVW7N3 RN Astrocytic -aminobutyric acid (GABA) transporters mediate guanidinoacetate transport in rat brain. 2018 Feb;113:1-7. DMVW7N3 RU http://www.ncbi.nlm.nih.gov/pubmed/29175673 DMVW7N3 DI DMVW7N3 DMVW7N3 DN Taurine DMVW7N3 MI DEUWCVD DMVW7N3 MN Transglutaminase Y (TGM6) DMVW7N3 MT DME DMVW7N3 MA Metabolism DMVW7N3 RN KEGG: new perspectives on genomes, pathways, diseases and drugs. Nucleic Acids Res. 2017 Jan 4;45(D1):D353-D361. (pathway:hsa00430) DMVW7N3 RU http://www.genome.jp/kegg-bin/show_pathway?hsa00430 DMEL9UT DI DMEL9UT DMEL9UT DN Taurochenodeoxycholic acid DMEL9UT MI DE4LYSA DMEL9UT MN Cytochrome P450 3A4 (CYP3A4) DMEL9UT MT DME DMEL9UT MA Metabolism DMEL9UT RN 6alpha-hydroxylation of taurochenodeoxycholic acid and lithocholic acid by CYP3A4 in human liver microsomes. Biochim Biophys Acta. 1999 Apr 19;1438(1):47-54. DMEL9UT RU https://www.ncbi.nlm.nih.gov/pubmed/?term=10216279 DMFKRQE DI DMFKRQE DMFKRQE DN Tauroursodeoxycholic acid DMFKRQE MI DTFI42L DMFKRQE MN Multidrug resistance-associated protein 2 (ABCC2) DMFKRQE MT DTP DMFKRQE MA Substrate DMFKRQE RN Human multidrug resistance protein 2 transports the therapeutic bile salt tauroursodeoxycholate. J Pharmacol Exp Ther. 2007 Feb;320(2):893-9. DMFKRQE RU https://doi.org/10.1124/jpet.106.106922 DMFKRQE DI DMFKRQE DMFKRQE DN Tauroursodeoxycholic acid DMFKRQE MI DTE2B1D DMFKRQE MN Organic anion transporting polypeptide 1A2 (SLCO1A2) DMFKRQE MT DTP DMFKRQE MA Substrate DMFKRQE RN Molecular and functional characterization of an organic anion transporting polypeptide cloned from human liver. Gastroenterology. 1995 Oct;109(4):1274-82. DMFKRQE RU http://www.ncbi.nlm.nih.gov/pubmed/7557095 DMC92DQ DI DMC92DQ DMC92DQ DN TAUTOMYCIN DMC92DQ MI TTFLH0E DMC92DQ MN Serine/threonine PP1-alpha (PPP1CA) DMC92DQ MT DTT DMC92DQ MA Inhibitor DMC92DQ RN Serine-threonine protein phosphatase inhibitors: development of potential therapeutic strategies. J Med Chem. 2002 Mar 14;45(6):1151-75. DMC92DQ RU https://pubmed.ncbi.nlm.nih.gov/11881984 DMCZIFS DI DMCZIFS DMCZIFS DN TB-101 DMCZIFS MI TT6L509 DMCZIFS MN Coagulation factor IIa (F2) DMCZIFS MT DTT DMCZIFS MA Modulator DMCZIFS RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2362). DMCZIFS RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2362 DMUN8CG DI DMUN8CG DMUN8CG DN TB-102 DMUN8CG MI TT6L509 DMUN8CG MN Coagulation factor IIa (F2) DMUN8CG MT DTT DMUN8CG MA Modulator DMUN8CG RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2362). DMUN8CG RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2362 DMFC3XP DI DMFC3XP DMFC3XP DN TBPS DMFC3XP MI TTBMV1G DMFC3XP MN GABA(A) receptor alpha-2 (GABRA2) DMFC3XP MT DTT DMFC3XP MA Blocker (channel blocker) DMFC3XP RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 405). DMFC3XP RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=405 DMFC3XP DI DMFC3XP DMFC3XP DN TBPS DMFC3XP MI TT37EDJ DMFC3XP MN GABA(A) receptor alpha-3 (GABRA3) DMFC3XP MT DTT DMFC3XP MA Blocker (channel blocker) DMFC3XP RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 406). DMFC3XP RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=406 DMFC3XP DI DMFC3XP DMFC3XP DN TBPS DMFC3XP MI TTNZPQ1 DMFC3XP MN GABA(A) receptor alpha-5 (GABRA5) DMFC3XP MT DTT DMFC3XP MA Blocker (channel blocker) DMFC3XP RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 408). DMFC3XP RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=408 DMFC3XP DI DMFC3XP DMFC3XP DN TBPS DMFC3XP MI TTZA1NY DMFC3XP MN GABA(A) receptor beta-2 (GABRB2) DMFC3XP MT DTT DMFC3XP MA Blocker (channel blocker) DMFC3XP RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 411). DMFC3XP RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=411 DMFC3XP DI DMFC3XP DMFC3XP DN TBPS DMFC3XP MI TTGXH6N DMFC3XP MN GABA(A) receptor delta (GABRD) DMFC3XP MT DTT DMFC3XP MA Blocker (channel blocker) DMFC3XP RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 416). DMFC3XP RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=416 DMFC3XP DI DMFC3XP DMFC3XP DN TBPS DMFC3XP MI TTBY4OD DMFC3XP MN GABA(A) receptor epsilon (GABRE) DMFC3XP MT DTT DMFC3XP MA Blocker (channel blocker) DMFC3XP RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 417). DMFC3XP RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=417 DMFC3XP DI DMFC3XP DMFC3XP DN TBPS DMFC3XP MI TT06RH5 DMFC3XP MN GABA(A) receptor gamma-2 (GABRG2) DMFC3XP MT DTT DMFC3XP MA Blocker (channel blocker) DMFC3XP RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 414). DMFC3XP RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=414 DMFC3XP DI DMFC3XP DMFC3XP DN TBPS DMFC3XP MI TTEX6LM DMFC3XP MN GABA(A) receptor gamma-3 (GABRG3) DMFC3XP MT DTT DMFC3XP MA Blocker (channel blocker) DMFC3XP RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 415). DMFC3XP RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=415 DMFC3XP DI DMFC3XP DMFC3XP DN TBPS DMFC3XP MI TT3E0DI DMFC3XP MN GABA(A) receptor pi (GABRP) DMFC3XP MT DTT DMFC3XP MA Blocker (channel blocker) DMFC3XP RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 419). DMFC3XP RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=419 DMFC3XP DI DMFC3XP DMFC3XP DN TBPS DMFC3XP MI TT6XFEU DMFC3XP MN GABA(A) receptor rho1 (GABRR1) DMFC3XP MT DTT DMFC3XP MA Blocker (channel blocker) DMFC3XP RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 420). DMFC3XP RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=420 DMFC3XP DI DMFC3XP DMFC3XP DN TBPS DMFC3XP MI TTQMXLS DMFC3XP MN GABA(A) receptor rho2 (GABRR2) DMFC3XP MT DTT DMFC3XP MA Blocker (channel blocker) DMFC3XP RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 421). DMFC3XP RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=421 DMFC3XP DI DMFC3XP DMFC3XP DN TBPS DMFC3XP MI TT4N6D8 DMFC3XP MN GABA(A) receptor rho3 (GABRR3) DMFC3XP MT DTT DMFC3XP MA Blocker (channel blocker) DMFC3XP RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 422). DMFC3XP RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=422 DMFC3XP DI DMFC3XP DMFC3XP DN TBPS DMFC3XP MI TTXDUR9 DMFC3XP MN GABA(A) receptor theta (GABRQ) DMFC3XP MT DTT DMFC3XP MA Blocker (channel blocker) DMFC3XP RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 418). DMFC3XP RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=418 DMKAX76 DI DMKAX76 DMKAX76 DN T-BuAc-RYYRIK-NH2 DMKAX76 MI TTNT7K8 DMKAX76 MN Nociceptin receptor (OPRL1) DMKAX76 MT DTT DMKAX76 MA Inhibitor DMKAX76 RN Designed modification of partial agonist of ORL1 nociceptin receptor for conversion into highly potent antagonist. Bioorg Med Chem. 2008 Mar 1;16(5):2635-44. DMKAX76 RU https://pubmed.ncbi.nlm.nih.gov/18068993 DMLNVH8 DI DMLNVH8 DMLNVH8 DN TC-2559 DMLNVH8 MI TT5KPZR DMLNVH8 MN Neuronal acetylcholine receptor beta-2 (CHRNB2) DMLNVH8 MT DTT DMLNVH8 MA Agonist DMLNVH8 RN The nicotinic alpha 4 beta 2 receptor selective agonist, TC-2559, increases dopamine neuronal activity in the ventral tegmental area of rat midbrain slices. Neuropharmacology. 2003 Sep;45(3):334-44. DMLNVH8 RU https://pubmed.ncbi.nlm.nih.gov/12871651 DM06DI1 DI DM06DI1 DM06DI1 DN TCI15 DM06DI1 MI TTMSB0A DM06DI1 MN Integrin alpha-2/beta-1 (ITGA2/B1) DM06DI1 MT DTT DM06DI1 MA Inhibitor DM06DI1 RN Small-molecule inhibitors of integrin alpha2beta1 that prevent pathological thrombus formation via an allosteric mechanism. Proc Natl Acad Sci U S A. 2009 Jan 20;106(3):719-24. DM06DI1 RU https://pubmed.ncbi.nlm.nih.gov/19141632 DMMT2GP DI DMMT2GP DMMT2GP DN TCN-201 DMMT2GP MI TTKJEMQ DMMT2GP MN Glutamate receptor ionotropic NMDA 2A (NMDAR2A) DMMT2GP MT DTT DMMT2GP MA Modulator (allosteric modulator) DMMT2GP RN Subunit-selective allosteric inhibition of glycine binding to NMDA receptors. J Neurosci. 2012 May 2;32(18):6197-208. DMMT2GP RU https://pubmed.ncbi.nlm.nih.gov/22553026 DMTF4VI DI DMTF4VI DMTF4VI DN TCPA DMTF4VI MI TTK25J1 DMTF4VI MN Adenosine A1 receptor (ADORA1) DMTF4VI MT DTT DMTF4VI MA Agonist DMTF4VI RN N6-cyclopentyl-2-(3-phenylaminocarbonyltriazene-1-yl)adenosine (TCPA), a very selective agonist with high affinity for the human adenosine A1 receptor. J Med Chem. 2003 Apr 10;46(8):1492-503. DMTF4VI RU https://pubmed.ncbi.nlm.nih.gov/12672250 DMTF4VI DI DMTF4VI DMTF4VI DN TCPA DMTF4VI MI TTNE7KG DMTF4VI MN Adenosine A2b receptor (ADORA2B) DMTF4VI MT DTT DMTF4VI MA Agonist DMTF4VI RN Heterologous expression of rat epitope-tagged histamine H2 receptors in insect Sf9 cells. Br J Pharmacol. 1997 Nov;122(5):867-74. DMTF4VI RU https://pubmed.ncbi.nlm.nih.gov/9384502 DMTF4VI DI DMTF4VI DMTF4VI DN TCPA DMTF4VI MI TTJFY5U DMTF4VI MN Adenosine A3 receptor (ADORA3) DMTF4VI MT DTT DMTF4VI MA Agonist DMTF4VI RN N6-cyclopentyl-2-(3-phenylaminocarbonyltriazene-1-yl)adenosine (TCPA), a very selective agonist with high affinity for the human adenosine A1 receptor. J Med Chem. 2003 Apr 10;46(8):1492-503. DMTF4VI RU https://pubmed.ncbi.nlm.nih.gov/12672250 DMKVF5Q DI DMKVF5Q DMKVF5Q DN TCPOBOP DMKVF5Q MI TTRANFM DMKVF5Q MN Orphan nuclear receptor NR1I3 (NR1I3) DMKVF5Q MT DTT DMKVF5Q MA Agonist DMKVF5Q RN The nuclear receptor CAR is a regulator of thyroid hormone metabolism during caloric restriction. J Biol Chem. 2004 May 7;279(19):19832-8. DMKVF5Q RU https://pubmed.ncbi.nlm.nih.gov/15004031 DMOLJRH DI DMOLJRH DMOLJRH DN TCS 2510 DMOLJRH MI TT79WV3 DMOLJRH MN Prostaglandin E2 receptor EP4 (PTGER4) DMOLJRH MT DTT DMOLJRH MA Agonist DMOLJRH RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 343). DMOLJRH RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=343 DMMUFSQ DI DMMUFSQ DMMUFSQ DN TCS 5861528 DMMUFSQ MI TTELV3W DMMUFSQ MN Transformation-sensitive protein p120 (TRPA1) DMMUFSQ MT DTT DMMUFSQ MA Inhibitor (gating inhibitor) DMMUFSQ RN Attenuation of mechanical hypersensitivity by an antagonist of the TRPA1 ion channel in diabetic animals. Anesthesiology. 2009 Jul;111(1):147-54. DMMUFSQ RU https://pubmed.ncbi.nlm.nih.gov/19512877 DMBVYQR DI DMBVYQR DMBVYQR DN TCS2314 DMBVYQR MI TT6S84X DMBVYQR MN Integrin alpha-4/beta-1 (ITGA4/B1) DMBVYQR MT DTT DMBVYQR MA Inhibitor DMBVYQR RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2580). DMBVYQR RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2580 DMH6UN8 DI DMH6UN8 DMH6UN8 DN TCS-359 DMH6UN8 MI TTGJCWZ DMH6UN8 MN Fms-like tyrosine kinase 3 (FLT-3) DMH6UN8 MT DTT DMH6UN8 MA Inhibitor DMH6UN8 RN Identification of 2-acylaminothiophene-3-carboxamides as potent inhibitors of FLT3. Bioorg Med Chem Lett. 2006 Jun 15;16(12):3282-6. DMH6UN8 RU https://pubmed.ncbi.nlm.nih.gov/16580199 DML8RTO DI DML8RTO DML8RTO DN TCS-OX2-29 DML8RTO MI TT9N02I DML8RTO MN Orexin receptor type 2 (HCRTR2) DML8RTO MT DTT DML8RTO MA Antagonist DML8RTO RN N-acyl 6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline: the first orexin-2 receptor selective non-peptidic antagonist. Bioorg Med Chem Lett. 2003 Dec 15;13(24):4497-9. DML8RTO RU https://pubmed.ncbi.nlm.nih.gov/14643355 DMQ7VDM DI DMQ7VDM DMQ7VDM DN TDI-0033 DMQ7VDM MI TTEDJN4 DMQ7VDM MN Low-affinity nerve growth factor receptor (NGFR) DMQ7VDM MT DTT DMQ7VDM MA Agonist DMQ7VDM RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1888). DMQ7VDM RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1888 DMSI9QM DI DMSI9QM DMSI9QM DN TDI-0059 DMSI9QM MI TTEDJN4 DMSI9QM MN Low-affinity nerve growth factor receptor (NGFR) DMSI9QM MT DTT DMSI9QM MA Modulator DMSI9QM RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1888). DMSI9QM RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1888 DMXHWAY DI DMXHWAY DMXHWAY DN TDI-0060 DMXHWAY MI TT6RVLG DMXHWAY MN Superoxide dismutase Cu-Zn (SOD Cu-Zn) DMXHWAY MT DTT DMXHWAY MA Modulator DMXHWAY RN Copper binding by tetrathiomolybdate attenuates angiogenesis and tumor cell proliferation through the inhibition of superoxide dismutase 1. Clin Cancer Res. 2006 Aug 15;12(16):4974-82. DMXHWAY RU https://pubmed.ncbi.nlm.nih.gov/16914587 DM5HEIR DI DM5HEIR DM5HEIR DN TDI-0079 DM5HEIR MI TT6RVLG DM5HEIR MN Superoxide dismutase Cu-Zn (SOD Cu-Zn) DM5HEIR MT DTT DM5HEIR MA Modulator DM5HEIR RN Copper binding by tetrathiomolybdate attenuates angiogenesis and tumor cell proliferation through the inhibition of superoxide dismutase 1. Clin Cancer Res. 2006 Aug 15;12(16):4974-82. DM5HEIR RU https://pubmed.ncbi.nlm.nih.gov/16914587 DMWGDXF DI DMWGDXF DMWGDXF DN TDI-0107 DMWGDXF MI TT6RVLG DMWGDXF MN Superoxide dismutase Cu-Zn (SOD Cu-Zn) DMWGDXF MT DTT DMWGDXF MA Inhibitor DMWGDXF RN Copper binding by tetrathiomolybdate attenuates angiogenesis and tumor cell proliferation through the inhibition of superoxide dismutase 1. Clin Cancer Res. 2006 Aug 15;12(16):4974-82. DMWGDXF RU https://pubmed.ncbi.nlm.nih.gov/16914587 DMRU8WT DI DMRU8WT DMRU8WT DN TDT-044 DMRU8WT MI TTPNQAC DMRU8WT MN Estrogen-related receptor-alpha (ESRRA) DMRU8WT MT DTT DMRU8WT MA Agonist DMRU8WT RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 622). DMRU8WT RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=622 DM0HJD4 DI DM0HJD4 DM0HJD4 DN tedisamil DM0HJD4 MI TTCVBT7 DM0HJD4 MN Voltage-gated potassium channel Kv1.7 (KCNA7) DM0HJD4 MT DTT DM0HJD4 MA Blocker (channel blocker) DM0HJD4 RN Genomic organization, chromosomal localization, tissue distribution, and biophysical characterization of a novel mammalian Shaker-related voltage-gated potassium channel, Kv1.7. J Biol Chem. 1998 Mar6;273(10):5851-7. DM0HJD4 RU https://pubmed.ncbi.nlm.nih.gov/9488722 DMRPFCS DI DMRPFCS DMRPFCS DN TEFLUDAZINE DMRPFCS MI TT3ROYC DMRPFCS MN Serotonin transporter (SERT) DMRPFCS MT DTT DMRPFCS MA Inhibitor DMRPFCS RN Neuroleptic activity and dopamine-uptake inhibition in 1-piperazino-3-phenylindans. J Med Chem. 1983 Jul;26(7):935-47. DMRPFCS RU https://pubmed.ncbi.nlm.nih.gov/6134833 DMBNYJW DI DMBNYJW DMBNYJW DN TEI-8362 DMBNYJW MI TTPLTSQ DMBNYJW MN Neutrophil elastase (NE) DMBNYJW MT DTT DMBNYJW MA Inhibitor DMBNYJW RN Neutrophil elastase inhibitors as treatment for COPD. Expert Opin Investig Drugs. 2002 Jul;11(7):965-80. DMBNYJW RU https://pubmed.ncbi.nlm.nih.gov/12084007 DMGQLYR DI DMGQLYR DMGQLYR DN TEI-9063 DMGQLYR MI TTOFYT1 DMGQLYR MN Prostacyclin receptor (PTGIR) DMGQLYR MT DTT DMGQLYR MA Agonist DMGQLYR RN Relaxant actions of nonprostanoid prostacyclin mimetics on human pulmonary artery. J Cardiovasc Pharmacol. 1997 Apr;29(4):525-35. DMGQLYR RU https://pubmed.ncbi.nlm.nih.gov/9156364 DMLDAR4 DI DMLDAR4 DMLDAR4 DN TEI-9647 DMLDAR4 MI TTK59TV DMLDAR4 MN Vitamin D3 receptor (VDR) DMLDAR4 MT DTT DMLDAR4 MA Antagonist DMLDAR4 RN Further synthetic and biological studies on vitamin D hormone antagonists based on C24-alkylation and C2alpha-functionalization of 25-dehydro-1alpha-hydroxyvitamin D(3)-26,23-lactones. J Med Chem. 2006 Nov 30;49(24):7063-75. DMLDAR4 RU https://pubmed.ncbi.nlm.nih.gov/17125259 DMSMLRB DI DMSMLRB DMSMLRB DN Teijin-lead_cmp_5 DMSMLRB MI TTFZYTO DMSMLRB MN C-C chemokine receptor type 2 (CCR2) DMSMLRB MT DTT DMSMLRB MA Antagonist DMSMLRB RN CCR2: characterization of the antagonist binding site from a combined receptor modeling/mutagenesis approach. J Med Chem. 2003 Sep 11;46(19):4070-86. DMSMLRB RU https://pubmed.ncbi.nlm.nih.gov/12954060 DM60HU5 DI DM60HU5 DM60HU5 DN Tellimagrandin II DM60HU5 MI TT6L509 DM60HU5 MN Coagulation factor IIa (F2) DM60HU5 MT DTT DM60HU5 MA Inhibitor DM60HU5 RN Effects of tannins from Geum japonicum on the catalytic activity of thrombin and factor Xa of blood coagulation cascade. J Nat Prod. 1998 Nov;61(11):1356-60. DM60HU5 RU https://pubmed.ncbi.nlm.nih.gov/9834152 DM60HU5 DI DM60HU5 DM60HU5 DN Tellimagrandin II DM60HU5 MI TTCIHJA DM60HU5 MN Coagulation factor Xa (F10) DM60HU5 MT DTT DM60HU5 MA Inhibitor DM60HU5 RN Effects of tannins from Geum japonicum on the catalytic activity of thrombin and factor Xa of blood coagulation cascade. J Nat Prod. 1998 Nov;61(11):1356-60. DM60HU5 RU https://pubmed.ncbi.nlm.nih.gov/9834152 DMGD0HT DI DMGD0HT DMGD0HT DN Tellurium DMGD0HT MI TTE14XG DMGD0HT MN Squalene monooxygenase (SQLE) DMGD0HT MT DTT DMGD0HT MA Inhibitor DMGD0HT RN Squalene epoxidase as hypocholesterolemic drug target revisited. Prog Lipid Res. 2003 Jan;42(1):37-50. DMGD0HT RU https://pubmed.ncbi.nlm.nih.gov/12467639 DM6EIVM DI DM6EIVM DM6EIVM DN Telomestatin DM6EIVM MI TTUJFD0 DM6EIVM MN Telomerase reverse transcriptase (TERT) DM6EIVM MT DTT DM6EIVM MA Inhibitor DM6EIVM RN Emerging therapies for multiple myeloma. Expert Opin Emerg Drugs. 2009 Mar;14(1):99-127. DM6EIVM RU https://pubmed.ncbi.nlm.nih.gov/19249983 DMT4NWX DI DMT4NWX DMT4NWX DN TELUDIPINE HYDROCHLORIDE DMT4NWX MI TT5HONZ DMT4NWX MN Calcium channel unspecific (CaC) DMT4NWX MT DTT DMT4NWX MA Blocker DMT4NWX RN Effects of R-enantiomer (GR66234A) and L-enantiomer (GR66235A) of telupidine, a new dihydropyridine derivative, on cell lines displaying the multidrug resistant phenotype. Haematologica. 1994 Jul-Aug;79(4):328-33. DMT4NWX RU https://pubmed.ncbi.nlm.nih.gov/7806087 DML53GP DI DML53GP DML53GP DN Tendamistat DML53GP MI TTHCF4J DML53GP MN Alpha-glucosidase (GLA) DML53GP MT DTT DML53GP MA Inhibitor DML53GP RN Influence of Specific Signal Peptide Mutations on the Expression and Secretion of the alpha -Amylase Inhibitor Tendamistat in Streptomyces lividans. J Biol Chem. 1996 Jun 21;271(25):15244-52. DML53GP RU https://pubmed.ncbi.nlm.nih.gov/8662986 DM1S209 DI DM1S209 DM1S209 DN TENELLONE A DM1S209 MI TTZC6DR DM1S209 MN cGMP-dependent protein kinase (cGK) DM1S209 MT DTT DM1S209 MA Inhibitor DM1S209 RN Tenellones A and B from a Diaporthe sp.: two highly substituted benzophenone inhibitors of parasite cGMP-dependent protein kinase activity. J Nat Prod. 2005 Apr;68(4):611-3. DM1S209 RU https://pubmed.ncbi.nlm.nih.gov/15844962 DM9ZVJ7 DI DM9ZVJ7 DM9ZVJ7 DN TENELLONE B DM9ZVJ7 MI TTZC6DR DM9ZVJ7 MN cGMP-dependent protein kinase (cGK) DM9ZVJ7 MT DTT DM9ZVJ7 MA Inhibitor DM9ZVJ7 RN Tenellones A and B from a Diaporthe sp.: two highly substituted benzophenone inhibitors of parasite cGMP-dependent protein kinase activity. J Nat Prod. 2005 Apr;68(4):611-3. DM9ZVJ7 RU https://pubmed.ncbi.nlm.nih.gov/15844962 DMRM1QV DI DMRM1QV DMRM1QV DN Tenocyclidine DMRM1QV MI TTKJEMQ DMRM1QV MN Glutamate receptor ionotropic NMDA 2A (NMDAR2A) DMRM1QV MT DTT DMRM1QV MA Antagonist DMRM1QV RN The binding of [3H]thienyl cyclohexylpiperidine ([3H]TCP) to the NMDA-phencyclidine receptor complex. Neuropharmacology. 1989 Jan;28(1):1-7. DMRM1QV RU https://pubmed.ncbi.nlm.nih.gov/2538766 DMRM1QV DI DMRM1QV DMRM1QV DN Tenocyclidine DMRM1QV MI TTN9D8E DMRM1QV MN Glutamate receptor ionotropic NMDA 2B (NMDAR2B) DMRM1QV MT DTT DMRM1QV MA Antagonist DMRM1QV RN The binding of [3H]thienyl cyclohexylpiperidine ([3H]TCP) to the NMDA-phencyclidine receptor complex. Neuropharmacology. 1989 Jan;28(1):1-7. DMRM1QV RU https://pubmed.ncbi.nlm.nih.gov/2538766 DMMLSZ4 DI DMMLSZ4 DMMLSZ4 DN TENOSAL DMMLSZ4 MI TTVKILB DMMLSZ4 MN Prostaglandin G/H synthase 2 (COX-2) DMMLSZ4 MT DTT DMMLSZ4 MA Inhibitor DMMLSZ4 RN US patent application no. 6,274,627, Conjugates of dithiocarbamate disulfides with pharmacologically active agents and uses therefor. DMMLSZ4 RU http://www.google.com/patents/US6274627 DMROS5K DI DMROS5K DMROS5K DN TEPA (possesses cytotoxic activity) DMROS5K MI TTZFYLI DMROS5K MN Dopamine D1 receptor (D1R) DMROS5K MT DTT DMROS5K MA Inhibitor DMROS5K RN N-(Iodopropenyl)-octahydrobenzo[f]- and -[g]quinolines: synthesis and adrenergic and dopaminergic activity studies. J Med Chem. 1998 Oct 8;41(21):4165-70. DMROS5K RU https://pubmed.ncbi.nlm.nih.gov/9767652 DMPX7QS DI DMPX7QS DMPX7QS DN TERRITREM B DMPX7QS MI TT1RS9F DMPX7QS MN Acetylcholinesterase (AChE) DMPX7QS MT DTT DMPX7QS MA Inhibitor DMPX7QS RN Acetylcholinesterase inhibition by territrem B derivatives. J Nat Prod. 1995 Jun;58(6):857-62. DMPX7QS RU https://pubmed.ncbi.nlm.nih.gov/7673929 DM8LI1K DI DM8LI1K DM8LI1K DN Tert-butyl (2S)-1-cyanopyrrolidine-2-carboxylate DM8LI1K MI TTDZN01 DM8LI1K MN Cathepsin K (CTSK) DM8LI1K MT DTT DM8LI1K MA Inhibitor DM8LI1K RN Acyclic cyanamide-based inhibitors of cathepsin K. Bioorg Med Chem Lett. 2005 Jun 15;15(12):3039-43. DM8LI1K RU https://pubmed.ncbi.nlm.nih.gov/15896958 DMW2X5V DI DMW2X5V DMW2X5V DN Tert-butyl 10H-phenothiazine-10-carboxylate DMW2X5V MI TTEB0GD DMW2X5V MN Cholinesterase (BCHE) DMW2X5V MT DTT DMW2X5V MA Inhibitor DMW2X5V RN Carbamates with differential mechanism of inhibition toward acetylcholinesterase and butyrylcholinesterase. J Med Chem. 2008 Jul 24;51(14):4200-12. DMW2X5V RU https://pubmed.ncbi.nlm.nih.gov/18570368 DMWQFY6 DI DMWQFY6 DMWQFY6 DN Tert-Butyl 2-(2-oxohexadecanamido)acetate DMWQFY6 MI TTT1JVS DMWQFY6 MN Cytosolic phospholipase A2 (GIVA cPLA2) DMWQFY6 MT DTT DMWQFY6 MA Inhibitor DMWQFY6 RN Structure-activity relationships of natural and non-natural amino acid-based amide and 2-oxoamide inhibitors of human phospholipase A(2) enzymes. Bioorg Med Chem. 2008 Dec 15;16(24):10257-69. DMWQFY6 RU https://pubmed.ncbi.nlm.nih.gov/18993078 DMZG5I7 DI DMZG5I7 DMZG5I7 DN TERT-BUTYL 2-CYANO-2-METHYLHYDRAZINECARBOXYLATE DMZG5I7 MI TTDZN01 DMZG5I7 MN Cathepsin K (CTSK) DMZG5I7 MT DTT DMZG5I7 MA Inhibitor DMZG5I7 RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DMZG5I7 RU https://pubmed.ncbi.nlm.nih.gov/10592235 DMNU9WV DI DMNU9WV DMNU9WV DN Tert-Butyl 3-(2-oxo-8-phenyloctanamido)propanoate DMNU9WV MI TTT1JVS DMNU9WV MN Cytosolic phospholipase A2 (GIVA cPLA2) DMNU9WV MT DTT DMNU9WV MA Inhibitor DMNU9WV RN Structure-activity relationships of natural and non-natural amino acid-based amide and 2-oxoamide inhibitors of human phospholipase A(2) enzymes. Bioorg Med Chem. 2008 Dec 15;16(24):10257-69. DMNU9WV RU https://pubmed.ncbi.nlm.nih.gov/18993078 DMYQXPB DI DMYQXPB DMYQXPB DN Tert-Butyl 3-(2-oxohexadecanamido)propanoate DMYQXPB MI TTT1JVS DMYQXPB MN Cytosolic phospholipase A2 (GIVA cPLA2) DMYQXPB MT DTT DMYQXPB MA Inhibitor DMYQXPB RN Structure-activity relationships of natural and non-natural amino acid-based amide and 2-oxoamide inhibitors of human phospholipase A(2) enzymes. Bioorg Med Chem. 2008 Dec 15;16(24):10257-69. DMYQXPB RU https://pubmed.ncbi.nlm.nih.gov/18993078 DM1ALTR DI DM1ALTR DM1ALTR DN Tert-Butyl 5-(2-oxohexadecanamido)pentanoate DM1ALTR MI TTT1JVS DM1ALTR MN Cytosolic phospholipase A2 (GIVA cPLA2) DM1ALTR MT DTT DM1ALTR MA Inhibitor DM1ALTR RN Structure-activity relationships of natural and non-natural amino acid-based amide and 2-oxoamide inhibitors of human phospholipase A(2) enzymes. Bioorg Med Chem. 2008 Dec 15;16(24):10257-69. DM1ALTR RU https://pubmed.ncbi.nlm.nih.gov/18993078 DM42WFH DI DM42WFH DM42WFH DN Tert-Butyl(1s)-1-Cyclohexyl-2-Oxoethylcarbamate DM42WFH MI TTDZN01 DM42WFH MN Cathepsin K (CTSK) DM42WFH MT DTT DM42WFH MA Inhibitor DM42WFH RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DM42WFH RU https://pubmed.ncbi.nlm.nih.gov/10592235 DMQKOUZ DI DMQKOUZ DMQKOUZ DN Tert-butyloxy carbonyl-D-Phe-pro-Arg-H DMQKOUZ MI TT2WR1T DMQKOUZ MN Cationic trypsinogen (PRSS1) DMQKOUZ MT DTT DMQKOUZ MA Inhibitor DMQKOUZ RN Structure-activity study of tripeptide thrombin inhibitors using alpha-alkyl amino acids and other conformationally constrained amino acid substitu... J Med Chem. 1995 Oct 27;38(22):4446-53. DMQKOUZ RU https://pubmed.ncbi.nlm.nih.gov/7473571 DMQDVNZ DI DMQDVNZ DMQDVNZ DN Testetrol DMQDVNZ MI TTS64P2 DMQDVNZ MN Androgen receptor (AR) DMQDVNZ MT DTT DMQDVNZ MA Agonist DMQDVNZ RN Estetrol review: profile and potential clinical applications. Climacteric. 2008;11 Suppl 1:47-58. DMQDVNZ RU https://pubmed.ncbi.nlm.nih.gov/18464023 DMKLIXZ DI DMKLIXZ DMKLIXZ DN Tetrabromocinnamic acid DMKLIXZ MI TTZ5NI7 DMKLIXZ MN Casein kinase II (CSNK2) DMKLIXZ MT DTT DMKLIXZ MA Inhibitor DMKLIXZ RN Tetrabromocinnamic acid (TBCA) and related compounds represent a new class of specific protein kinase CK2 inhibitors. Chembiochem. 2007 Jan 2;8(1):129-39. DMKLIXZ RU https://pubmed.ncbi.nlm.nih.gov/17133643 DMX5MAU DI DMX5MAU DMX5MAU DN Tetrabutylammonium Ion DMX5MAU MI TTYOMFZ DMX5MAU MN Voltage-gated potassium channel (VGKC) DMX5MAU MT DTT DMX5MAU MA Inhibitor DMX5MAU RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMX5MAU RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMK8P61 DI DMK8P61 DMK8P61 DN Tetradecane DMK8P61 MI TT7O8ZA DMK8P61 MN Lanosterol synthase (LSS) DMK8P61 MT DTT DMK8P61 MA Inhibitor DMK8P61 RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMK8P61 RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMABITD DI DMABITD DMABITD DN Tetradecyl-phosphonic acid DMABITD MI TTQ6S1K DMABITD MN Lysophosphatidic acid receptor 1 (LPAR1) DMABITD MT DTT DMABITD MA Inhibitor DMABITD RN Synthesis, structure-activity relationships, and biological evaluation of fatty alcohol phosphates as lysophosphatidic acid receptor ligands, activ... J Med Chem. 2005 Jul 28;48(15):4919-30. DMABITD RU https://pubmed.ncbi.nlm.nih.gov/16033271 DMH4AGL DI DMH4AGL DMH4AGL DN Tetraethylene Glycol DMH4AGL MI TT1RS9F DMH4AGL MN Acetylcholinesterase (AChE) DMH4AGL MT DTT DMH4AGL MA Inhibitor DMH4AGL RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMH4AGL RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMDWUCX DI DMDWUCX DMDWUCX DN Tetragastrin DMDWUCX MI TTCG0AL DMDWUCX MN Cholecystokinin receptor type A (CCKAR) DMDWUCX MT DTT DMDWUCX MA Inhibitor DMDWUCX RN Synthesis and binding affinities of analogues of cholecystokinin-(30-33) as probes for central nervous system cholecystokinin receptors. J Med Chem. 1987 Apr;30(4):729-32. DMDWUCX RU https://pubmed.ncbi.nlm.nih.gov/3560164 DMDWUCX DI DMDWUCX DMDWUCX DN Tetragastrin DMDWUCX MI TTVFO0U DMDWUCX MN Gastrin/cholecystokinin type B receptor (CCKBR) DMDWUCX MT DTT DMDWUCX MA Inhibitor DMDWUCX RN Synthesis and binding affinities of analogues of cholecystokinin-(30-33) as probes for central nervous system cholecystokinin receptors. J Med Chem. 1987 Apr;30(4):729-32. DMDWUCX RU https://pubmed.ncbi.nlm.nih.gov/3560164 DM2QKOU DI DM2QKOU DM2QKOU DN Tetrahydroaldosterone DM2QKOU MI DEB3CV1 DM2QKOU MN UDP-glucuronosyltransferase 2B7 (UGT2B7) DM2QKOU MT DME DM2QKOU MA Metabolism DM2QKOU RN Human uridine diphosphate-glucuronosyltransferase UGT2B7 conjugates mineralocorticoid and glucocorticoid metabolites. Endocrinology. 2003 Jun;144(6):2659-68. DM2QKOU RU https://www.ncbi.nlm.nih.gov/pubmed/?term=12746330 DMNURE0 DI DMNURE0 DMNURE0 DN TETRAHYDROBENXIMIDAZOLE DMNURE0 MI TT06AWU DMNURE0 MN Phosphodiesterase 3A (PDE3A) DMNURE0 MT DTT DMNURE0 MA Inhibitor DMNURE0 RN Cardiotonic agents. 9. Synthesis and biological evaluation of a series of (E)-4,5-dihydro-6-[2-[4-(1H-imidazol-1-yl)phenyl]ethenyl]-3 (2H)-pyridazi... J Med Chem. 1989 Feb;32(2):342-50. DMNURE0 RU https://pubmed.ncbi.nlm.nih.gov/2536438 DMDY1MZ DI DMDY1MZ DMDY1MZ DN tetrahydrocannabivarin DMDY1MZ MI TT946IA DMDY1MZ MN Transient receptor potential cation channel V3 (TRPV3) DMDY1MZ MT DTT DMDY1MZ MA Activator DMDY1MZ RN Cannabinoid actions at TRPV channels: effects on TRPV3 and TRPV4 and their potential relevance to gastrointestinal inflammation. Acta Physiol (Oxf). 2012 Feb;204(2):255-66. DMDY1MZ RU https://pubmed.ncbi.nlm.nih.gov/21726418 DMF8M0W DI DMF8M0W DMF8M0W DN tetrahydrodeoxycorticosterone DMF8M0W MI TTBMV1G DMF8M0W MN GABA(A) receptor alpha-2 (GABRA2) DMF8M0W MT DTT DMF8M0W MA Modulator (allosteric modulator) DMF8M0W RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 405). DMF8M0W RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=405 DMF8M0W DI DMF8M0W DMF8M0W DN tetrahydrodeoxycorticosterone DMF8M0W MI TT37EDJ DMF8M0W MN GABA(A) receptor alpha-3 (GABRA3) DMF8M0W MT DTT DMF8M0W MA Modulator (allosteric modulator) DMF8M0W RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 406). DMF8M0W RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=406 DMF8M0W DI DMF8M0W DMF8M0W DN tetrahydrodeoxycorticosterone DMF8M0W MI TTNZPQ1 DMF8M0W MN GABA(A) receptor alpha-5 (GABRA5) DMF8M0W MT DTT DMF8M0W MA Modulator (allosteric modulator) DMF8M0W RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 408). DMF8M0W RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=408 DMF8M0W DI DMF8M0W DMF8M0W DN tetrahydrodeoxycorticosterone DMF8M0W MI TTEX6LM DMF8M0W MN GABA(A) receptor gamma-3 (GABRG3) DMF8M0W MT DTT DMF8M0W MA Modulator (allosteric modulator) DMF8M0W RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 415). DMF8M0W RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=415 DMNH3ST DI DMNH3ST DMNH3ST DN Tetrahydroimidazo[4,5,1-jk]-[1,4]benzodiazepin-2(1H)-one DMNH3ST MI TT84ETX DMNH3ST MN Human immunodeficiency virus Reverse transcriptase (HIV RT) DMNH3ST MT DTT DMNH3ST MA Inhibitor DMNH3ST RN Chimeric human immunodeficiency virus type 1/type 2 reverse transcriptases display reversed sensitivity to nonnucleoside analog inhibitors. Proc Natl Acad Sci U S A. 1991 Nov 1;88(21):9878-82. DMNH3ST RU https://pubmed.ncbi.nlm.nih.gov/1719542 DMMU6WQ DI DMMU6WQ DMMU6WQ DN Tetrahydro-pyrimidin-2-ylideneamine DMMU6WQ MI TTZUFI5 DMMU6WQ MN Nitric-oxide synthase brain (NOS1) DMMU6WQ MT DTT DMMU6WQ MA Inhibitor DMMU6WQ RN 2-Iminopiperidine and other 2-iminoazaheterocycles as potent inhibitors of human nitric oxide synthase isoforms. J Med Chem. 1996 Feb 2;39(3):669-72. DMMU6WQ RU https://pubmed.ncbi.nlm.nih.gov/8576908 DMWRZJX DI DMWRZJX DMWRZJX DN TETRAHYDROQUINOLINE A DMWRZJX MI TTFQAYR DMWRZJX MN Cholesteryl ester transfer protein (CETP) DMWRZJX MT DTT DMWRZJX MA Inhibitor DMWRZJX RN Design and synthesis of potent inhibitors of cholesteryl ester transfer protein (CETP) exploiting a 1,2,3,4-tetrahydroquinoline platform. Bioorg Med Chem Lett. 2009 May 1;19(9):2456-60. DMWRZJX RU https://pubmed.ncbi.nlm.nih.gov/19339179 DMHT61V DI DMHT61V DMHT61V DN TETRAHYDROQUINOLINE B DMHT61V MI TTFQAYR DMHT61V MN Cholesteryl ester transfer protein (CETP) DMHT61V MT DTT DMHT61V MA Inhibitor DMHT61V RN Design and synthesis of potent inhibitors of cholesteryl ester transfer protein (CETP) exploiting a 1,2,3,4-tetrahydroquinoline platform. Bioorg Med Chem Lett. 2009 May 1;19(9):2456-60. DMHT61V RU https://pubmed.ncbi.nlm.nih.gov/19339179 DMWOBAE DI DMWOBAE DMWOBAE DN tetralin_urea analogue (7o) DMWOBAE MI TTX4RTB DMWOBAE MN Melanin-concentrating hormone receptor 1 (MCHR1) DMWOBAE MT DTT DMWOBAE MA Antagonist DMWOBAE RN Discovery of tetralin ureas as potent melanin concentrating hormone 1 receptor antagonists. Bioorg Med Chem Lett. 2007 Mar 15;17(6):1718-21. DMWOBAE RU https://pubmed.ncbi.nlm.nih.gov/17251014 DMLEPYN DI DMLEPYN DMLEPYN DN Tetramethylammonium Ion DMLEPYN MI DTT79CX DMLEPYN MN Organic cation transporter 1 (SLC22A1) DMLEPYN MT DTP DMLEPYN MA Substrate DMLEPYN RN Scintillation proximity assay for measuring uptake by the human drug transporters hOCT1, hOAT3, and hOATP1B1. Anal Biochem. 2007 Jul 15;366(2):117-25. DMLEPYN RU http://www.ncbi.nlm.nih.gov/pubmed/17555702 DMLEPYN DI DMLEPYN DMLEPYN DN Tetramethylammonium Ion DMLEPYN MI TTGRHIB DMLEPYN MN UDP-glucose 4-epimerase (GALE) DMLEPYN MT DTT DMLEPYN MA Inhibitor DMLEPYN RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMLEPYN RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMW9CH2 DI DMW9CH2 DMW9CH2 DN Tetramethylbutylphenol DMW9CH2 MI DE0P6LK DMW9CH2 MN Sulfotransferase 2A1 (SULT2A1) DMW9CH2 MT DME DMW9CH2 MA Metabolism DMW9CH2 RN Sulfation of environmental estrogens by cytosolic human sulfotransferases. Drug Metab Pharmacokinet. 2002;17(3):221-8. DMW9CH2 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=15618673 DM8T7CG DI DM8T7CG DM8T7CG DN tetronothiodin DM8T7CG MI TTVFO0U DM8T7CG MN Gastrin/cholecystokinin type B receptor (CCKBR) DM8T7CG MT DTT DM8T7CG MA Antagonist DM8T7CG RN Species specificity of pharmacological characteristics of CCK-B receptors. Neurosci Lett. 1993 Aug 6;158(1):1-4. DM8T7CG RU https://pubmed.ncbi.nlm.nih.gov/8233061 DMHBMJZ DI DMHBMJZ DMHBMJZ DN Textilinin DMHBMJZ MI TTP86E2 DMHBMJZ MN Plasminogen (PLG) DMHBMJZ MT DTT DMHBMJZ MA Inhibitor DMHBMJZ RN Tranexamic acid in trauma: how should we use it. J Trauma Acute Care Surg. 2013 Jun;74(6):1575-86. DMHBMJZ RU https://pubmed.ncbi.nlm.nih.gov/23694890 DMAC8TP DI DMAC8TP DMAC8TP DN TFMPP DMAC8TP MI TTSQIFT DMAC8TP MN 5-HT 1A receptor (HTR1A) DMAC8TP MT DTT DMAC8TP MA Inhibitor DMAC8TP RN Synthesis and evaluation of phenyl- and benzoylpiperazines as potential serotonergic agents. J Med Chem. 1986 May;29(5):630-4. DMAC8TP RU https://pubmed.ncbi.nlm.nih.gov/3701781 DMAC8TP DI DMAC8TP DMAC8TP DN TFMPP DMAC8TP MI TTK8CXU DMAC8TP MN 5-HT 1B receptor (HTR1B) DMAC8TP MT DTT DMAC8TP MA Agonist DMAC8TP RN Two amino acid differences in the sixth transmembrane domain are partially responsible for the pharmacological differences between the 5-HT1D beta and 5-HT1E 5-hydroxytryptamine receptors. J Neurochem. 1996 Nov;67(5):2096-103. DMAC8TP RU https://pubmed.ncbi.nlm.nih.gov/8863519 DMAC8TP DI DMAC8TP DMAC8TP DN TFMPP DMAC8TP MI TT6MSOK DMAC8TP MN 5-HT 1D receptor (HTR1D) DMAC8TP MT DTT DMAC8TP MA Agonist DMAC8TP RN Primary structure and functional characterization of a human 5-HT1D-type serotonin receptor. Mol Pharmacol. 1991 Aug;40(2):143-8. DMAC8TP RU https://pubmed.ncbi.nlm.nih.gov/1652050 DMAC8TP DI DMAC8TP DMAC8TP DN TFMPP DMAC8TP MI TTCPG9S DMAC8TP MN 5-HT 1E receptor (HTR1E) DMAC8TP MT DTT DMAC8TP MA Agonist DMAC8TP RN Molecular cloning and pharmacological characterization of the guinea pig 5-HT1E receptor. Eur J Pharmacol. 2004 Jan 26;484(2-3):127-39. DMAC8TP RU https://pubmed.ncbi.nlm.nih.gov/14744596 DMAC8TP DI DMAC8TP DMAC8TP DN TFMPP DMAC8TP MI TT0MI3F DMAC8TP MN 5-HT 1F receptor (HTR1F) DMAC8TP MT DTT DMAC8TP MA Agonist DMAC8TP RN Cloning of another human serotonin receptor (5-HT1F): a fifth 5-HT1 receptor subtype coupled to the inhibition of adenylate cyclase. Proc Natl Acad Sci U S A. 1993 Jan 15;90(2):408-12. DMAC8TP RU https://pubmed.ncbi.nlm.nih.gov/8380639 DMAC8TP DI DMAC8TP DMAC8TP DN TFMPP DMAC8TP MI TTJQOD7 DMAC8TP MN 5-HT 2A receptor (HTR2A) DMAC8TP MT DTT DMAC8TP MA Agonist DMAC8TP RN Pharmacological characterisation of the agonist radioligand binding site of 5-HT(2A), 5-HT(2B) and 5-HT(2C) receptors. Naunyn Schmiedebergs Arch Pharmacol. 2004 Aug;370(2):114-23. DMAC8TP RU https://pubmed.ncbi.nlm.nih.gov/15322733 DMAC8TP DI DMAC8TP DMAC8TP DN TFMPP DMAC8TP MI TT0K1SC DMAC8TP MN 5-HT 2B receptor (HTR2B) DMAC8TP MT DTT DMAC8TP MA Agonist DMAC8TP RN Pharmacological characteristics of the newly cloned rat 5-hydroxytryptamine2F receptor. Mol Pharmacol. 1993 Mar;43(3):419-26. DMAC8TP RU https://pubmed.ncbi.nlm.nih.gov/8450835 DMAC8TP DI DMAC8TP DMAC8TP DN TFMPP DMAC8TP MI TTWJBZ5 DMAC8TP MN 5-HT 2C receptor (HTR2C) DMAC8TP MT DTT DMAC8TP MA Agonist DMAC8TP RN Agonist high and low affinity state ratios predict drug intrinsic activity and a revised ternary complex mechanism at serotonin 5-HT(2A) and 5-HT(2C) receptors. Synapse. 2000 Feb;35(2):144-50. DMAC8TP RU https://pubmed.ncbi.nlm.nih.gov/10611640 DMAC8TP DI DMAC8TP DMAC8TP DN TFMPP DMAC8TP MI TTRUFDT DMAC8TP MN 5-HT 5A receptor (HTR5A) DMAC8TP MT DTT DMAC8TP MA Agonist DMAC8TP RN Mouse 5-hydroxytryptamine5A and 5-hydroxytryptamine5B receptors define a new family of serotonin receptors: cloning, functional expression, and chromosomal localization. Mol Pharmacol. 1993 Mar;43(3):313-9. DMAC8TP RU https://pubmed.ncbi.nlm.nih.gov/8450829 DMAC8TP DI DMAC8TP DMAC8TP DN TFMPP DMAC8TP MI TTJS8PY DMAC8TP MN 5-HT 6 receptor (HTR6) DMAC8TP MT DTT DMAC8TP MA Agonist DMAC8TP RN Cloning and expression of a novel serotonin receptor with high affinity for tricyclic psychotropic drugs. Mol Pharmacol. 1993 Mar;43(3):320-7. DMAC8TP RU https://pubmed.ncbi.nlm.nih.gov/7680751 DMAC8TP DI DMAC8TP DMAC8TP DN TFMPP DMAC8TP MI TTO9X1H DMAC8TP MN 5-HT 7 receptor (HTR7) DMAC8TP MT DTT DMAC8TP MA Agonist DMAC8TP RN Molecular cloning and expression of a 5-hydroxytryptamine7 serotonin receptor subtype. J Biol Chem. 1993 Aug 25;268(24):18200-4. DMAC8TP RU https://pubmed.ncbi.nlm.nih.gov/8394362 DMIR3X2 DI DMIR3X2 DMIR3X2 DN TG-100435 DMIR3X2 MI TTI4ZX2 DMIR3X2 MN Ephrin type-B receptor 4 (EPHB4) DMIR3X2 MT DTT DMIR3X2 MA Inhibitor DMIR3X2 RN Discovery of [7-(2,6-dichlorophenyl)-5-methylbenzo [1,2,4]triazin-3-yl]-[4-(2-pyrrolidin-1-ylethoxy)phenyl]amine--a potent, orally active Src kinas... Bioorg Med Chem Lett. 2007 Feb 1;17(3):602-8. DMIR3X2 RU https://pubmed.ncbi.nlm.nih.gov/17113292 DMIR3X2 DI DMIR3X2 DMIR3X2 DN TG-100435 DMIR3X2 MI TTGJVQM DMIR3X2 MN Fibroblast growth factor receptor 2 (FGFR2) DMIR3X2 MT DTT DMIR3X2 MA Inhibitor DMIR3X2 RN Discovery of [7-(2,6-dichlorophenyl)-5-methylbenzo [1,2,4]triazin-3-yl]-[4-(2-pyrrolidin-1-ylethoxy)phenyl]amine--a potent, orally active Src kinas... Bioorg Med Chem Lett. 2007 Feb 1;17(3):602-8. DMIR3X2 RU https://pubmed.ncbi.nlm.nih.gov/17113292 DMIR3X2 DI DMIR3X2 DMIR3X2 DN TG-100435 DMIR3X2 MI TT860QF DMIR3X2 MN LCK tyrosine protein kinase (LCK) DMIR3X2 MT DTT DMIR3X2 MA Inhibitor DMIR3X2 RN Discovery of [7-(2,6-dichlorophenyl)-5-methylbenzo [1,2,4]triazin-3-yl]-[4-(2-pyrrolidin-1-ylethoxy)phenyl]amine--a potent, orally active Src kinas... Bioorg Med Chem Lett. 2007 Feb 1;17(3):602-8. DMIR3X2 RU https://pubmed.ncbi.nlm.nih.gov/17113292 DMIR3X2 DI DMIR3X2 DMIR3X2 DN TG-100435 DMIR3X2 MI TTI7421 DMIR3X2 MN Platelet-derived growth factor receptor beta (PDGFRB) DMIR3X2 MT DTT DMIR3X2 MA Inhibitor DMIR3X2 RN Discovery of [7-(2,6-dichlorophenyl)-5-methylbenzo [1,2,4]triazin-3-yl]-[4-(2-pyrrolidin-1-ylethoxy)phenyl]amine--a potent, orally active Src kinas... Bioorg Med Chem Lett. 2007 Feb 1;17(3):602-8. DMIR3X2 RU https://pubmed.ncbi.nlm.nih.gov/17113292 DMIR3X2 DI DMIR3X2 DMIR3X2 DN TG-100435 DMIR3X2 MI TT4DXQT DMIR3X2 MN Proto-oncogene c-Ret (RET) DMIR3X2 MT DTT DMIR3X2 MA Inhibitor DMIR3X2 RN Discovery of [7-(2,6-dichlorophenyl)-5-methylbenzo [1,2,4]triazin-3-yl]-[4-(2-pyrrolidin-1-ylethoxy)phenyl]amine--a potent, orally active Src kinas... Bioorg Med Chem Lett. 2007 Feb 1;17(3):602-8. DMIR3X2 RU https://pubmed.ncbi.nlm.nih.gov/17113292 DMIR3X2 DI DMIR3X2 DMIR3X2 DN TG-100435 DMIR3X2 MI TT6PKBN DMIR3X2 MN Proto-oncogene c-Src (SRC) DMIR3X2 MT DTT DMIR3X2 MA Inhibitor DMIR3X2 RN Discovery of [7-(2,6-dichlorophenyl)-5-methylbenzo [1,2,4]triazin-3-yl]-[4-(2-pyrrolidin-1-ylethoxy)phenyl]amine--a potent, orally active Src kinas... Bioorg Med Chem Lett. 2007 Feb 1;17(3):602-8. DMIR3X2 RU https://pubmed.ncbi.nlm.nih.gov/17113292 DMIR3X2 DI DMIR3X2 DMIR3X2 DN TG-100435 DMIR3X2 MI TT3PJMV DMIR3X2 MN Tyrosine-protein kinase ABL1 (ABL) DMIR3X2 MT DTT DMIR3X2 MA Inhibitor DMIR3X2 RN Discovery of [7-(2,6-dichlorophenyl)-5-methylbenzo [1,2,4]triazin-3-yl]-[4-(2-pyrrolidin-1-ylethoxy)phenyl]amine--a potent, orally active Src kinas... Bioorg Med Chem Lett. 2007 Feb 1;17(3):602-8. DMIR3X2 RU https://pubmed.ncbi.nlm.nih.gov/17113292 DMIR3X2 DI DMIR3X2 DMIR3X2 DN TG-100435 DMIR3X2 MI TTUTJGQ DMIR3X2 MN Vascular endothelial growth factor receptor 2 (KDR) DMIR3X2 MT DTT DMIR3X2 MA Inhibitor DMIR3X2 RN Discovery of [7-(2,6-dichlorophenyl)-5-methylbenzo [1,2,4]triazin-3-yl]-[4-(2-pyrrolidin-1-ylethoxy)phenyl]amine--a potent, orally active Src kinas... Bioorg Med Chem Lett. 2007 Feb 1;17(3):602-8. DMIR3X2 RU https://pubmed.ncbi.nlm.nih.gov/17113292 DMIR3X2 DI DMIR3X2 DMIR3X2 DN TG-100435 DMIR3X2 MI TT0SQ8J DMIR3X2 MN Yes tyrosine kinase (YES) DMIR3X2 MT DTT DMIR3X2 MA Inhibitor DMIR3X2 RN Discovery of [7-(2,6-dichlorophenyl)-5-methylbenzo [1,2,4]triazin-3-yl]-[4-(2-pyrrolidin-1-ylethoxy)phenyl]amine--a potent, orally active Src kinas... Bioorg Med Chem Lett. 2007 Feb 1;17(3):602-8. DMIR3X2 RU https://pubmed.ncbi.nlm.nih.gov/17113292 DMSG0TL DI DMSG0TL DMSG0TL DN TG-1022 DMSG0TL MI TTLAFZV DMSG0TL MN AMP-activated protein kinase (AMPK) DMSG0TL MT DTT DMSG0TL MA Stimulator DMSG0TL RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1540). DMSG0TL RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1540 DM5VJQP DI DM5VJQP DM5VJQP DN TG-1031 DM5VJQP MI TTF89GD DM5VJQP MN Interleukin-2 (IL2) DM5VJQP MT DTT DM5VJQP MA Modulator DM5VJQP RN Technology evaluation: TG-1031, Transgene SA.Curr Opin Mol Ther.2000 Feb;2(1):106-11. DM5VJQP RU https://www.ncbi.nlm.nih.gov/pubmed/11249647 DM5VJQP DI DM5VJQP DM5VJQP DN TG-1031 DM5VJQP MI TTBHFYQ DM5VJQP MN Mucin-1 (MUC1) DM5VJQP MT DTT DM5VJQP MA Modulator DM5VJQP RN Technology evaluation: TG-1031, Transgene SA.Curr Opin Mol Ther.2000 Feb;2(1):106-11. DM5VJQP RU https://www.ncbi.nlm.nih.gov/pubmed/11249647 DMRFAVG DI DMRFAVG DMRFAVG DN TG-2001 DMRFAVG MI TTF89GD DMRFAVG MN Interleukin-2 (IL2) DMRFAVG MT DTT DMRFAVG MA Modulator DMRFAVG RN Immunotherapy of metastatic melanoma by intratumoral injections of Vero cells producing human IL-2: phase II randomized study comparing two dose le... Cancer Gene Ther. 2002 Mar;9(3):289-95. DMRFAVG RU https://www.ncbi.nlm.nih.gov/pubmed/11896446 DMHTEMP DI DMHTEMP DMHTEMP DN TG-3003 DMHTEMP MI TTC70AJ DMHTEMP MN Granulocyte colony-stimulating factor receptor (G-CSF-R) DMHTEMP MT DTT DMHTEMP RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1719). DMHTEMP RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1719 DM8RSDE DI DM8RSDE DM8RSDE DN TG-3030 DM8RSDE MI TTDCVZW DM8RSDE MN Gamma-aminobutyric acid B receptor (GABBR) DM8RSDE MT DTT DM8RSDE MA Agonist DM8RSDE RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 241). DM8RSDE RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=241 DM862TI DI DM862TI DM862TI DN TG4-155 DM862TI MI TT1ZAVI DM862TI MN Prostaglandin E2 receptor EP2 (PTGER2) DM862TI MT DTT DM862TI MA Antagonist DM862TI RN Small molecule antagonist reveals seizure-induced mediation of neuronal injury by prostaglandin E2 receptor subtype EP2. Proc Natl Acad Sci U S A. 2012 Feb 21;109(8):3149-54. DM862TI RU https://pubmed.ncbi.nlm.nih.gov/22323596 DM0OHL3 DI DM0OHL3 DM0OHL3 DN TG7-171 DM0OHL3 MI TT1ZAVI DM0OHL3 MN Prostaglandin E2 receptor EP2 (PTGER2) DM0OHL3 MT DTT DM0OHL3 MA Antagonist DM0OHL3 RN Development of second generation EP2 antagonists with high selectivity. Eur J Med Chem. 2014 Jul 23;82:521-35. DM0OHL3 RU https://pubmed.ncbi.nlm.nih.gov/24937185 DMBFX7S DI DMBFX7S DMBFX7S DN TgBSSL DMBFX7S MI TTTRNQW DMBFX7S MN Bile-salt-activated lipase (CEL) DMBFX7S MT DTT DMBFX7S MA Modulator DMBFX7S RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2872). DMBFX7S RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2872 DMOX3AH DI DMOX3AH DMOX3AH DN TGF alpha DMOX3AH MI TTGKNB4 DMOX3AH MN Epidermal growth factor receptor (EGFR) DMOX3AH MT DTT DMOX3AH MA Modulator DMOX3AH RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1797). DMOX3AH RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1797 DMUP34S DI DMUP34S DMUP34S DN TGF-beta Shield DMUP34S MI TTP4520 DMUP34S MN TGF-beta receptor type I (TGFBR1) DMUP34S MT DTT DMUP34S MA Antagonist DMUP34S RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1788). DMUP34S RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1788 DM1BVW3 DI DM1BVW3 DM1BVW3 DN TGSC01AA(4) DM1BVW3 MI TTPTXIN DM1BVW3 MN Translocator protein (TSPO) DM1BVW3 MT DTT DM1BVW3 MA Binder DM1BVW3 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2879). DM1BVW3 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2879 DMM0LRE DI DMM0LRE DMM0LRE DN TGX-221 DMM0LRE MI TTTHBCA DMM0LRE MN PI3-kinase beta (PIK3CB) DMM0LRE MT DTT DMM0LRE MA Inhibitor DMM0LRE RN PI 3-kinase p110beta: a new target for antithrombotic therapy. Nat Med. 2005 May;11(5):507-14. DMM0LRE RU https://pubmed.ncbi.nlm.nih.gov/15834429 DMM0LRE DI DMM0LRE DMM0LRE DN TGX-221 DMM0LRE MI TTHBTOP DMM0LRE MN PI3-kinase gamma (PIK3CG) DMM0LRE MT DTT DMM0LRE MA Inhibitor DMM0LRE RN PI 3-kinase p110beta: a new target for antithrombotic therapy. Nat Med. 2005 May;11(5):507-14. DMM0LRE RU https://pubmed.ncbi.nlm.nih.gov/15834429 DMLC8PX DI DMLC8PX DMLC8PX DN TH-1320 DMLC8PX MI TTGTQHC DMLC8PX MN DNA topoisomerase I (TOP1) DMLC8PX MT DTT DMLC8PX MA Modulator DMLC8PX RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2636). DMLC8PX RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2636 DMKCY0X DI DMKCY0X DMKCY0X DN THA-902 DMKCY0X MI TTLGDIS DMKCY0X MN Acid-sensing ion channel 3 (ASIC3) DMKCY0X MT DTT DMKCY0X MA Antagonist DMKCY0X RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 686). DMKCY0X RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=686 DMQSO7V DI DMQSO7V DMQSO7V DN THA-904 DMQSO7V MI TTVMWLP DMQSO7V MN Acid-sensing ion channel 2 (ASIC2) DMQSO7V MT DTT DMQSO7V MA Antagonist DMQSO7V RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 685). DMQSO7V RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=685 DMG6S2V DI DMG6S2V DMG6S2V DN THEASINENSIN A DMG6S2V MI TTE14XG DMG6S2V MN Squalene monooxygenase (SQLE) DMG6S2V MT DTT DMG6S2V MA Inhibitor DMG6S2V RN Ellagitannins and hexahydroxydiphenoyl esters as inhibitors of vertebrate squalene epoxidase. J Nat Prod. 2001 Aug;64(8):1010-4. DMG6S2V RU https://pubmed.ncbi.nlm.nih.gov/11520216 DMRCD3O DI DMRCD3O DMRCD3O DN THEBAINE DMRCD3O MI TTKWM86 DMRCD3O MN Opioid receptor mu (MOP) DMRCD3O MT DTT DMRCD3O MA Inhibitor DMRCD3O RN Live cell monitoring of mu-opioid receptor-mediated G-protein activation reveals strong biological activity of close morphine biosynthetic precursors. J Biol Chem. 2007 Sep 14;282(37):27126-32. DMRCD3O RU https://pubmed.ncbi.nlm.nih.gov/17616524 DMRVXFN DI DMRVXFN DMRVXFN DN Theliatinib DMRVXFN MI TTGKNB4 DMRVXFN MN Epidermal growth factor receptor (EGFR) DMRVXFN MT DTT DMRVXFN MA Inhibitor DMRVXFN RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1797). DMRVXFN RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1797 DM54OKX DI DM54OKX DM54OKX DN Thenoyltrifluoroacetone DM54OKX MI TTMF541 DM54OKX MN Liver carboxylesterase (CES1) DM54OKX MT DTT DM54OKX MA Inhibitor DM54OKX RN Zhang JG, Fariss MW: Thenoyltrifluoroacetone, a potent inhibitor of carboxylesterase activity. Biochem Pharmacol. 2002 Feb 15;63(4):751-4. DM54OKX RU https://pubmed.ncbi.nlm.nih.gov/11992644 DM9CF45 DI DM9CF45 DM9CF45 DN thiadiazolidinone (TDZD) deriv. 6 DM9CF45 MI TTGTKX9 DM9CF45 MN Regulator of G-protein signaling 4 (RGS4) DM9CF45 MT DTT DM9CF45 MA Inhibitor DM9CF45 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2811). DM9CF45 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2811 DM9CF45 DI DM9CF45 DM9CF45 DN thiadiazolidinone (TDZD) deriv. 6 DM9CF45 MI TTWME23 DM9CF45 MN Regulator of G-protein signaling 8 (RGS8) DM9CF45 MT DTT DM9CF45 MA Inhibitor DM9CF45 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2813). DM9CF45 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2813 DMKRG2C DI DMKRG2C DMKRG2C DN Thiadiazolo[2,3-a]pyrimidine DMKRG2C MI TTSUKYD DMKRG2C MN Virus RNA-dependent RNA polymerase (Viru RdRP) DMKRG2C MT DTT DMKRG2C MA Inhibitor DMKRG2C RN Activity of T-705 in a hamster model of yellow fever virus infection in comparison with that of a chemically related compound, T-1106. Antimicrob Agents Chemother. 2009 Jan;53(1):202-9. DMKRG2C RU https://pubmed.ncbi.nlm.nih.gov/18955536 DM3F25L DI DM3F25L DM3F25L DN Thiamin Diphosphate DM3F25L MI TTUTN1I DM3F25L MN Human Deoxyribonucleic acid (hDNA) DM3F25L MT DTT DM3F25L MA Inhibitor DM3F25L RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DM3F25L RU https://pubmed.ncbi.nlm.nih.gov/17139284 DM5WYJ6 DI DM5WYJ6 DM5WYJ6 DN Thiamine pyrophosphate DM5WYJ6 MI DTT82QK DM5WYJ6 MN Mitochondrial thiamine pyrophosphate carrier (SLC25A19) DM5WYJ6 MT DTP DM5WYJ6 MA Substrate DM5WYJ6 RN Knockout of Slc25a19 causes mitochondrial thiamine pyrophosphate depletion, embryonic lethality, CNS malformations, and anemia. Proc Natl Acad Sci U S A. 2006 Oct 24;103(43):15927-32. DM5WYJ6 RU http://www.ncbi.nlm.nih.gov/pubmed/17035501 DM5WYJ6 DI DM5WYJ6 DM5WYJ6 DN Thiamine pyrophosphate DM5WYJ6 MI DT9V8W1 DM5WYJ6 MN Solute carrier family 35 member E4 (SLC35E4) DM5WYJ6 MT DTP DM5WYJ6 MA Substrate DM5WYJ6 RN The Transporter Classification Database (TCDB): recent advances. Nucleic Acids Res. 2016 Jan 4;44(D1):D372-9. (ID: 2.A.7.9.11) DM5WYJ6 RU http://www.tcdb.org/search/result.php?tc=2.A.7.9.11 DMIOTHG DI DMIOTHG DMIOTHG DN Thieno analogue of kenpaullone DMIOTHG MI TTH6V3D DMIOTHG MN Cyclin-dependent kinase 1 (CDK1) DMIOTHG MT DTT DMIOTHG MA Inhibitor DMIOTHG RN 1-Azakenpaullone is a selective inhibitor of glycogen synthase kinase-3 beta. Bioorg Med Chem Lett. 2004 Jan 19;14(2):413-6. DMIOTHG RU https://pubmed.ncbi.nlm.nih.gov/14698171 DMIOTHG DI DMIOTHG DMIOTHG DN Thieno analogue of kenpaullone DMIOTHG MI TTL4Q97 DMIOTHG MN Cyclin-dependent kinase 5 (CDK5) DMIOTHG MT DTT DMIOTHG MA Inhibitor DMIOTHG RN 1-Azakenpaullone is a selective inhibitor of glycogen synthase kinase-3 beta. Bioorg Med Chem Lett. 2004 Jan 19;14(2):413-6. DMIOTHG RU https://pubmed.ncbi.nlm.nih.gov/14698171 DMIOTHG DI DMIOTHG DMIOTHG DN Thieno analogue of kenpaullone DMIOTHG MI TT9P6OW DMIOTHG MN G2/mitotic-specific cyclin B1 (CCNB1) DMIOTHG MT DTT DMIOTHG MA Inhibitor DMIOTHG RN 1-Azakenpaullone is a selective inhibitor of glycogen synthase kinase-3 beta. Bioorg Med Chem Lett. 2004 Jan 19;14(2):413-6. DMIOTHG RU https://pubmed.ncbi.nlm.nih.gov/14698171 DMIOTHG DI DMIOTHG DMIOTHG DN Thieno analogue of kenpaullone DMIOTHG MI TTRSMW9 DMIOTHG MN Glycogen synthase kinase-3 beta (GSK-3B) DMIOTHG MT DTT DMIOTHG MA Inhibitor DMIOTHG RN 1-Azakenpaullone is a selective inhibitor of glycogen synthase kinase-3 beta. Bioorg Med Chem Lett. 2004 Jan 19;14(2):413-6. DMIOTHG RU https://pubmed.ncbi.nlm.nih.gov/14698171 DMUL2FW DI DMUL2FW DMUL2FW DN Thieno[2,3-B]Pyridine-2-Carboxamidine DMUL2FW MI TTGY7WI DMUL2FW MN Urokinase-type plasminogen activator (PLAU) DMUL2FW MT DTT DMUL2FW MA Inhibitor DMUL2FW RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DMUL2FW RU https://pubmed.ncbi.nlm.nih.gov/10592235 DMT74N6 DI DMT74N6 DMT74N6 DN Thieno[3,2-e][1]benzothiophene-4,5-dione DMT74N6 MI TTMF541 DMT74N6 MN Liver carboxylesterase (CES1) DMT74N6 MT DTT DMT74N6 MA Inhibitor DMT74N6 RN Planarity and constraint of the carbonyl groups in 1,2-diones are determinants for selective inhibition of human carboxylesterase 1. J Med Chem. 2007 Nov 15;50(23):5727-34. DMT74N6 RU https://pubmed.ncbi.nlm.nih.gov/17941623 DMFDROW DI DMFDROW DMFDROW DN Thieno-phenanthridin-6-one DMFDROW MI TTVDSZ0 DMFDROW MN Poly [ADP-ribose] polymerase 1 (PARP1) DMFDROW MT DTT DMFDROW MA Inhibitor DMFDROW RN Poly(ADP-ribose) polymerase and the therapeutic effects of its inhibitors. Nat Rev Drug Discov. 2005 May;4(5):421-40. DMFDROW RU https://pubmed.ncbi.nlm.nih.gov/15864271 DMQ0YB5 DI DMQ0YB5 DMQ0YB5 DN Thiethylperazine DMQ0YB5 MI TTAIY2U DMQ0YB5 MN HUMAN clathrin-mediated endocytosis (RME) DMQ0YB5 MT DTT DMQ0YB5 MA Inhibitor DMQ0YB5 RN Repurposing of clinically developed drugs for treatment of Middle East respiratory syndrome coronavirus infection. Antimicrob Agents Chemother. 2014 Aug;58(8):4885-93. DMQ0YB5 RU https://pubmed.ncbi.nlm.nih.gov/24841273 DM3KU46 DI DM3KU46 DM3KU46 DN THIIC DM3KU46 MI TTXJ47W DM3KU46 MN Metabotropic glutamate receptor 2 (mGluR2) DM3KU46 MT DTT DM3KU46 MA Modulator (allosteric modulator) DM3KU46 RN N-(4-((2-(trifluoromethyl)-3-hydroxy-4-(isobutyryl)phenoxy)methyl)benzyl)-1-methyl-1H-imidazole-4-carboxamide (THIIC), a novel metabotropic glutamate 2 potentiator with potential anxiolytic/antidepressant properties: in vivo profiling suggests a link between behavioral and central nervous system neurochemical changes. J Pharmacol Exp Ther. 2011 Jan;336(1):165-77. DM3KU46 RU https://pubmed.ncbi.nlm.nih.gov/20947638 DMBOKSF DI DMBOKSF DMBOKSF DN Thioacetic acid S-(6-phenylcarbamoyl-hexyl) ester DMBOKSF MI TTBH0VX DMBOKSF MN Histone deacetylase (HDAC) DMBOKSF MT DTT DMBOKSF MA Inhibitor DMBOKSF RN Novel inhibitors of human histone deacetylases: design, synthesis, enzyme inhibition, and cancer cell growth inhibition of SAHA-based non-hydroxama... J Med Chem. 2005 Feb 24;48(4):1019-32. DMBOKSF RU https://pubmed.ncbi.nlm.nih.gov/15715470 DMBOKSF DI DMBOKSF DMBOKSF DN Thioacetic acid S-(6-phenylcarbamoyl-hexyl) ester DMBOKSF MI TT6R7JZ DMBOKSF MN Histone deacetylase 1 (HDAC1) DMBOKSF MT DTT DMBOKSF MA Inhibitor DMBOKSF RN Novel inhibitors of human histone deacetylases: design, synthesis, enzyme inhibition, and cancer cell growth inhibition of SAHA-based non-hydroxama... J Med Chem. 2005 Feb 24;48(4):1019-32. DMBOKSF RU https://pubmed.ncbi.nlm.nih.gov/15715470 DMBOKSF DI DMBOKSF DMBOKSF DN Thioacetic acid S-(6-phenylcarbamoyl-hexyl) ester DMBOKSF MI TTYHPU6 DMBOKSF MN Histone deacetylase 10 (HDAC10) DMBOKSF MT DTT DMBOKSF MA Inhibitor DMBOKSF RN Novel inhibitors of human histone deacetylases: design, synthesis, enzyme inhibition, and cancer cell growth inhibition of SAHA-based non-hydroxama... J Med Chem. 2005 Feb 24;48(4):1019-32. DMBOKSF RU https://pubmed.ncbi.nlm.nih.gov/15715470 DMBOKSF DI DMBOKSF DMBOKSF DN Thioacetic acid S-(6-phenylcarbamoyl-hexyl) ester DMBOKSF MI TTSHTOI DMBOKSF MN Histone deacetylase 2 (HDAC2) DMBOKSF MT DTT DMBOKSF MA Inhibitor DMBOKSF RN Novel inhibitors of human histone deacetylases: design, synthesis, enzyme inhibition, and cancer cell growth inhibition of SAHA-based non-hydroxama... J Med Chem. 2005 Feb 24;48(4):1019-32. DMBOKSF RU https://pubmed.ncbi.nlm.nih.gov/15715470 DMBOKSF DI DMBOKSF DMBOKSF DN Thioacetic acid S-(6-phenylcarbamoyl-hexyl) ester DMBOKSF MI TTTQGH8 DMBOKSF MN Histone deacetylase 4 (HDAC4) DMBOKSF MT DTT DMBOKSF MA Inhibitor DMBOKSF RN Novel inhibitors of human histone deacetylases: design, synthesis, enzyme inhibition, and cancer cell growth inhibition of SAHA-based non-hydroxama... J Med Chem. 2005 Feb 24;48(4):1019-32. DMBOKSF RU https://pubmed.ncbi.nlm.nih.gov/15715470 DMBOKSF DI DMBOKSF DMBOKSF DN Thioacetic acid S-(6-phenylcarbamoyl-hexyl) ester DMBOKSF MI TT5ZKDI DMBOKSF MN Histone deacetylase 6 (HDAC6) DMBOKSF MT DTT DMBOKSF MA Inhibitor DMBOKSF RN Novel inhibitors of human histone deacetylases: design, synthesis, enzyme inhibition, and cancer cell growth inhibition of SAHA-based non-hydroxama... J Med Chem. 2005 Feb 24;48(4):1019-32. DMBOKSF RU https://pubmed.ncbi.nlm.nih.gov/15715470 DMBOKSF DI DMBOKSF DMBOKSF DN Thioacetic acid S-(6-phenylcarbamoyl-hexyl) ester DMBOKSF MI TTT6LFV DMBOKSF MN Histone deacetylase 8 (HDAC8) DMBOKSF MT DTT DMBOKSF MA Inhibitor DMBOKSF RN Novel inhibitors of human histone deacetylases: design, synthesis, enzyme inhibition, and cancer cell growth inhibition of SAHA-based non-hydroxama... J Med Chem. 2005 Feb 24;48(4):1019-32. DMBOKSF RU https://pubmed.ncbi.nlm.nih.gov/15715470 DM76EPH DI DM76EPH DM76EPH DN thio-BCTC DM76EPH MI TTXDKTO DM76EPH MN Long transient receptor potential channel 8 (TRPM8) DM76EPH MT DTT DM76EPH MA Blocker (channel blocker) DM76EPH RN Characterization of the mouse cold-menthol receptor TRPM8 and vanilloid receptor type-1 VR1 using a fluorometric imaging plate reader (FLIPR) assay. Br J Pharmacol. 2004 Feb;141(4):737-45. DM76EPH RU https://pubmed.ncbi.nlm.nih.gov/14757700 DMP7LJH DI DMP7LJH DMP7LJH DN Thiocarbamate DMP7LJH MI TTE14XG DMP7LJH MN Squalene monooxygenase (SQLE) DMP7LJH MT DTT DMP7LJH MA Inhibitor DMP7LJH RN Characterization of squalene epoxidase activity from the dermatophyte Trichophyton rubrum and its inhibition by terbinafine and other antimycotic agents. Antimicrob Agents Chemother. 1996 Feb;40(2):443-7. DMP7LJH RU https://pubmed.ncbi.nlm.nih.gov/8834895 DML4TQ5 DI DML4TQ5 DML4TQ5 DN thiochrome DML4TQ5 MI TTOXS3C DML4TQ5 MN Muscarinic acetylcholine receptor (CHRM) DML4TQ5 MT DTT DML4TQ5 MA Modulator (allosteric modulator) DML4TQ5 RN Thiochrome enhances acetylcholine affinity at muscarinic M4 receptors: receptor subtype selectivity via cooperativity rather than affinity. Mol Pharmacol. 2004 Jan;65(1):257-66. DML4TQ5 RU https://pubmed.ncbi.nlm.nih.gov/14722259 DML4TQ5 DI DML4TQ5 DML4TQ5 DN thiochrome DML4TQ5 MI TTQ13Z5 DML4TQ5 MN Muscarinic acetylcholine receptor M3 (CHRM3) DML4TQ5 MT DTT DML4TQ5 MA Modulator (allosteric modulator) DML4TQ5 RN Thiochrome enhances acetylcholine affinity at muscarinic M4 receptors: receptor subtype selectivity via cooperativity rather than affinity. Mol Pharmacol. 2004 Jan;65(1):257-66. DML4TQ5 RU https://pubmed.ncbi.nlm.nih.gov/14722259 DM7X8MH DI DM7X8MH DM7X8MH DN THIOCITRULLINE DM7X8MH MI TTZUFI5 DM7X8MH MN Nitric-oxide synthase brain (NOS1) DM7X8MH MT DTT DM7X8MH MA Inhibitor DM7X8MH RN Evaluation of 3-substituted arginine analogs as selective inhibitors of human nitric oxide synthase isozymes. Bioorg Med Chem Lett. 2005 Jun 2;15(11):2881-5. DM7X8MH RU https://pubmed.ncbi.nlm.nih.gov/15911272 DM7X8MH DI DM7X8MH DM7X8MH DN THIOCITRULLINE DM7X8MH MI TTCM4B3 DM7X8MH MN Nitric-oxide synthase endothelial (NOS3) DM7X8MH MT DTT DM7X8MH MA Inhibitor DM7X8MH RN Evaluation of 3-substituted arginine analogs as selective inhibitors of human nitric oxide synthase isozymes. Bioorg Med Chem Lett. 2005 Jun 2;15(11):2881-5. DM7X8MH RU https://pubmed.ncbi.nlm.nih.gov/15911272 DM7X8MH DI DM7X8MH DM7X8MH DN THIOCITRULLINE DM7X8MH MI TTF10I9 DM7X8MH MN Nitric-oxide synthase inducible (NOS2) DM7X8MH MT DTT DM7X8MH MA Inhibitor DM7X8MH RN Evaluation of 3-substituted arginine analogs as selective inhibitors of human nitric oxide synthase isozymes. Bioorg Med Chem Lett. 2005 Jun 2;15(11):2881-5. DM7X8MH RU https://pubmed.ncbi.nlm.nih.gov/15911272 DMJSKIP DI DMJSKIP DMJSKIP DN Thiocolchicine DMJSKIP MI TTML2WA DMJSKIP MN Tubulin (TUB) DMJSKIP MT DTT DMJSKIP MA Inhibitor DMJSKIP RN Antitumor agents. 139. Synthesis and biological evaluation of thiocolchicine analogs 5,6-dihydro-6(S)-(acyloxy)- and 5,6-dihydro-6(S)-[(aroyloxy)me... J Med Chem. 1993 Mar 5;36(5):544-51. DMJSKIP RU https://pubmed.ncbi.nlm.nih.gov/8496935 DMJSKIP DI DMJSKIP DMJSKIP DN Thiocolchicine DMJSKIP MI TTYFKSZ DMJSKIP MN Tubulin beta (TUBB) DMJSKIP MT DTT DMJSKIP MA Inhibitor DMJSKIP RN Antitumor agents. 139. Synthesis and biological evaluation of thiocolchicine analogs 5,6-dihydro-6(S)-(acyloxy)- and 5,6-dihydro-6(S)-[(aroyloxy)me... J Med Chem. 1993 Mar 5;36(5):544-51. DMJSKIP RU https://pubmed.ncbi.nlm.nih.gov/8496935 DMPTSN0 DI DMPTSN0 DMPTSN0 DN Thiocoumarin DMPTSN0 MI TTF10I9 DMPTSN0 MN Nitric-oxide synthase inducible (NOS2) DMPTSN0 MT DTT DMPTSN0 MA Inhibitor DMPTSN0 RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DMPTSN0 RU https://pubmed.ncbi.nlm.nih.gov/10592235 DMNFCXW DI DMNFCXW DMNFCXW DN THIOCTIC ACID DMNFCXW MI TT1RS9F DMNFCXW MN Acetylcholinesterase (AChE) DMNFCXW MT DTT DMNFCXW MA Inhibitor DMNFCXW RN Multi-target-directed ligands to combat neurodegenerative diseases. J Med Chem. 2008 Feb 14;51(3):347-72. DMNFCXW RU https://pubmed.ncbi.nlm.nih.gov/18181565 DMNFCXW DI DMNFCXW DMNFCXW DN THIOCTIC ACID DMNFCXW MI TTVKILB DMNFCXW MN Prostaglandin G/H synthase 2 (COX-2) DMNFCXW MT DTT DMNFCXW MA Inhibitor DMNFCXW RN Investigations concerning the COX/5-LOX inhibiting and hydroxyl radical scavenging potencies of novel 4,5-diaryl isoselenazoles. Eur J Med Chem. 2008 Jun;43(6):1152-9. DMNFCXW RU https://pubmed.ncbi.nlm.nih.gov/17976864 DMK2J5L DI DMK2J5L DMK2J5L DN THIOGENISTEIN DMK2J5L MI TTOM3J0 DMK2J5L MN Estrogen receptor beta (ESR2) DMK2J5L MT DTT DMK2J5L MA Inhibitor DMK2J5L RN Synthesis and characterization of 3-arylquinazolinone and 3-arylquinazolinethione derivatives as selective estrogen receptor beta modulators. J Med Chem. 2006 Apr 20;49(8):2440-55. DMK2J5L RU https://pubmed.ncbi.nlm.nih.gov/16610787 DMBAWDG DI DMBAWDG DMBAWDG DN Thiolactomycin DMBAWDG MI TT0O4QL DMBAWDG MN Bacterial Beta-ketoacyl-ACP synthase I (Bact fabB) DMBAWDG MT DTT DMBAWDG MA Binder DMBAWDG RN Therapeutic target database update 2012: a resource for facilitating target-oriented drug discovery. Nucleic Acids Res. 2012 Jan;40(Database issue):D1128-36. DMBAWDG RU https://pubmed.ncbi.nlm.nih.gov/21948793 DMBAWDG DI DMBAWDG DMBAWDG DN Thiolactomycin DMBAWDG MI TTRVTMX DMBAWDG MN Bacterial Beta-ketoacyl-ACP synthase III (Bact fabH) DMBAWDG MT DTT DMBAWDG MA Binder DMBAWDG RN The apicoplast as an antimalarial drug target. Drug Resist Updat. 2001 Jun;4(3):145-51. DMBAWDG RU https://pubmed.ncbi.nlm.nih.gov/11768328 DMBAWDG DI DMBAWDG DMBAWDG DN Thiolactomycin DMBAWDG MI TTRFV0W DMBAWDG MN Bacterial Oxoacyl-[acyl-carrier-protein] synthase II (Bact fabF) DMBAWDG MT DTT DMBAWDG MA Binder DMBAWDG RN Therapeutic target database update 2012: a resource for facilitating target-oriented drug discovery. Nucleic Acids Res. 2012 Jan;40(Database issue):D1128-36. DMBAWDG RU https://pubmed.ncbi.nlm.nih.gov/21948793 DMBAWDG DI DMBAWDG DMBAWDG DN Thiolactomycin DMBAWDG MI TTNX2CS DMBAWDG MN Plasmodium Enoyl-ACP reductase (Malaria fabI) DMBAWDG MT DTT DMBAWDG MA Inhibitor DMBAWDG RN Novel molecular targets for antimalarial drug development. Chem Biol Drug Des. 2008 Apr;71(4):287-97. DMBAWDG RU https://pubmed.ncbi.nlm.nih.gov/18298458 DMAKW2S DI DMAKW2S DMAKW2S DN Thiophene sulfonamide DMAKW2S MI TTSFWA7 DMAKW2S MN Plasmodium CDK Pfmrk (Malaria Pfmrk) DMAKW2S MT DTT DMAKW2S MA Inhibitor DMAKW2S RN Novel molecular targets for antimalarial drug development. Chem Biol Drug Des. 2008 Apr;71(4):287-97. DMAKW2S RU https://pubmed.ncbi.nlm.nih.gov/18298458 DML3OHW DI DML3OHW DML3OHW DN Thiophene-2-ylboronic acid DML3OHW MI TTHI19T DML3OHW MN Staphylococcus Beta-lactamase (Stap-coc blaZ) DML3OHW MT DTT DML3OHW MA Inhibitor DML3OHW RN Optimizing cell permeation of an antibiotic resistance inhibitor for improved efficacy. J Med Chem. 2007 Nov 15;50(23):5644-54. DML3OHW RU https://pubmed.ncbi.nlm.nih.gov/17956081 DMZ4FCB DI DMZ4FCB DMZ4FCB DN Thiophosphoric acid (E)-dodec-9-enyl ester DMZ4FCB MI TTQ6S1K DMZ4FCB MN Lysophosphatidic acid receptor 1 (LPAR1) DMZ4FCB MT DTT DMZ4FCB MA Inhibitor DMZ4FCB RN Synthesis, structure-activity relationships, and biological evaluation of fatty alcohol phosphates as lysophosphatidic acid receptor ligands, activ... J Med Chem. 2005 Jul 28;48(15):4919-30. DMZ4FCB RU https://pubmed.ncbi.nlm.nih.gov/16033271 DMYOXJ4 DI DMYOXJ4 DMYOXJ4 DN Thiophosphoric acid (E)-tetradec-9-enyl ester DMYOXJ4 MI TTQ6S1K DMYOXJ4 MN Lysophosphatidic acid receptor 1 (LPAR1) DMYOXJ4 MT DTT DMYOXJ4 MA Inhibitor DMYOXJ4 RN Synthesis, structure-activity relationships, and biological evaluation of fatty alcohol phosphates as lysophosphatidic acid receptor ligands, activ... J Med Chem. 2005 Jul 28;48(15):4919-30. DMYOXJ4 RU https://pubmed.ncbi.nlm.nih.gov/16033271 DM12NGE DI DM12NGE DM12NGE DN Thiophosphoric acid dec-9-enyl ester DM12NGE MI TTQ6S1K DM12NGE MN Lysophosphatidic acid receptor 1 (LPAR1) DM12NGE MT DTT DM12NGE MA Inhibitor DM12NGE RN Synthesis, structure-activity relationships, and biological evaluation of fatty alcohol phosphates as lysophosphatidic acid receptor ligands, activ... J Med Chem. 2005 Jul 28;48(15):4919-30. DM12NGE RU https://pubmed.ncbi.nlm.nih.gov/16033271 DM36KW9 DI DM36KW9 DM36KW9 DN Thiophosphoric acid decyl ester DM36KW9 MI TTQ6S1K DM36KW9 MN Lysophosphatidic acid receptor 1 (LPAR1) DM36KW9 MT DTT DM36KW9 MA Inhibitor DM36KW9 RN Synthesis, structure-activity relationships, and biological evaluation of fatty alcohol phosphates as lysophosphatidic acid receptor ligands, activ... J Med Chem. 2005 Jul 28;48(15):4919-30. DM36KW9 RU https://pubmed.ncbi.nlm.nih.gov/16033271 DM86LFB DI DM86LFB DM86LFB DN Thiorphan DM86LFB MI TT5TKPM DM86LFB MN Neutral endopeptidase (MME) DM86LFB MT DTT DM86LFB MA Inhibitor DM86LFB RN Thiorphan enhances bradykinin-induced vascular relaxation in hypoxic/hyperkalaemic porcine coronary artery. J Pharm Pharmacol. 2003 Mar;55(3):339-45. DM86LFB RU https://pubmed.ncbi.nlm.nih.gov/12724039 DML7Y1R DI DML7Y1R DML7Y1R DN Thiostrepton DML7Y1R MI TTLFGBV DML7Y1R MN Bacterial 23S ribosomal RNA (Bact 23S rRNA) DML7Y1R MT DTT DML7Y1R MA Binder DML7Y1R RN The apicoplast as an antimalarial drug target. Drug Resist Updat. 2001 Jun;4(3):145-51. DML7Y1R RU https://pubmed.ncbi.nlm.nih.gov/11768328 DMUELHN DI DMUELHN DMUELHN DN Thiourea DMUELHN MI DTMF8LB DMUELHN MN Urea transporter 1 (SLC14A1) DMUELHN MT DTP DMUELHN MA Substrate DMUELHN RN Functional differentiation of the human red blood cell and kidney urea transporters. Am J Physiol. 1996 Dec;271(6 Pt 2):F1264-8. DMUELHN RU http://www.ncbi.nlm.nih.gov/pubmed/8997401 DM8WYEM DI DM8WYEM DM8WYEM DN Thioureido sulfonamide DM8WYEM MI TTHQPL7 DM8WYEM MN Carbonic anhydrase I (CA-I) DM8WYEM MT DTT DM8WYEM MA Inhibitor DM8WYEM RN Carbonic anhydrase inhibitors: design of thioureido sulfonamides with potent isozyme II and XII inhibitory properties and intraocular pressure lowe... Bioorg Med Chem Lett. 2005 Sep 1;15(17):3821-7. DM8WYEM RU https://pubmed.ncbi.nlm.nih.gov/16039853 DM8WYEM DI DM8WYEM DM8WYEM DN Thioureido sulfonamide DM8WYEM MI TTANPDJ DM8WYEM MN Carbonic anhydrase II (CA-II) DM8WYEM MT DTT DM8WYEM MA Inhibitor DM8WYEM RN Carbonic anhydrase inhibitors: design of thioureido sulfonamides with potent isozyme II and XII inhibitory properties and intraocular pressure lowe... Bioorg Med Chem Lett. 2005 Sep 1;15(17):3821-7. DM8WYEM RU https://pubmed.ncbi.nlm.nih.gov/16039853 DM8WYEM DI DM8WYEM DM8WYEM DN Thioureido sulfonamide DM8WYEM MI TTSYM0R DM8WYEM MN Carbonic anhydrase XII (CA-XII) DM8WYEM MT DTT DM8WYEM MA Inhibitor DM8WYEM RN Carbonic anhydrase inhibitors: design of thioureido sulfonamides with potent isozyme II and XII inhibitory properties and intraocular pressure lowe... Bioorg Med Chem Lett. 2005 Sep 1;15(17):3821-7. DM8WYEM RU https://pubmed.ncbi.nlm.nih.gov/16039853 DMP8LSF DI DMP8LSF DMP8LSF DN THIQ DMP8LSF MI TTD0CIQ DMP8LSF MN Melanocortin receptor 4 (MC4R) DMP8LSF MT DTT DMP8LSF MA Agonist DMP8LSF RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 285). DMP8LSF RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=285 DMD1G6R DI DMD1G6R DMD1G6R DN THPG DMD1G6R MI TTWRP2F DMD1G6R MN Metabotropic glutamate receptor 6 (mGluR6) DMD1G6R MT DTT DMD1G6R MA Antagonist DMD1G6R RN Two phenylglycine derivatives antagonize responses to L-AP4 in ON bipolar cells of the amphibian retina. Neuropharmacology. 1997 Jan;36(1):13-20. DMD1G6R RU https://pubmed.ncbi.nlm.nih.gov/9144637 DMJD479 DI DMJD479 DMJD479 DN THPO DMJD479 MI TTV9MQG DMJD479 MN Gamma-aminobutyric acid uptake (GABAU) DMJD479 MT DTT DMJD479 MA Inhibitor DMJD479 RN Anticonvulsant activity of intracerebroventricularly administered glial GABA uptake inhibitors and other GABAmimetics in chemical seizure models. Epilepsy Res. 1989 Jul-Aug;4(1):34-41. DMJD479 RU https://pubmed.ncbi.nlm.nih.gov/2526732 DM4W1E8 DI DM4W1E8 DM4W1E8 DN Threo-1-aza-5-phenyl[4.4.0]decane hydrochloride DM4W1E8 MI TTVBI8W DM4W1E8 MN Dopamine transporter (DAT) DM4W1E8 MT DTT DM4W1E8 MA Inhibitor DM4W1E8 RN Synthesis and pharmacology of site-specific cocaine abuse treatment agents: restricted rotation analogues of methylphenidate. J Med Chem. 2007 May 31;50(11):2718-31. DM4W1E8 RU https://pubmed.ncbi.nlm.nih.gov/17489581 DM4W1E8 DI DM4W1E8 DM4W1E8 DN Threo-1-aza-5-phenyl[4.4.0]decane hydrochloride DM4W1E8 MI TT3ROYC DM4W1E8 MN Serotonin transporter (SERT) DM4W1E8 MT DTT DM4W1E8 MA Inhibitor DM4W1E8 RN Synthesis and pharmacology of site-specific cocaine abuse treatment agents: restricted rotation analogues of methylphenidate. J Med Chem. 2007 May 31;50(11):2718-31. DM4W1E8 RU https://pubmed.ncbi.nlm.nih.gov/17489581 DMA7GTH DI DMA7GTH DMA7GTH DN Threo-3,4-dichlororitalinol hydrochloride DMA7GTH MI TTVBI8W DMA7GTH MN Dopamine transporter (DAT) DMA7GTH MT DTT DMA7GTH MA Inhibitor DMA7GTH RN Synthesis and pharmacology of site-specific cocaine abuse treatment agents: restricted rotation analogues of methylphenidate. J Med Chem. 2007 May 31;50(11):2718-31. DMA7GTH RU https://pubmed.ncbi.nlm.nih.gov/17489581 DMA7GTH DI DMA7GTH DMA7GTH DN Threo-3,4-dichlororitalinol hydrochloride DMA7GTH MI TT3ROYC DMA7GTH MN Serotonin transporter (SERT) DMA7GTH MT DTT DMA7GTH MA Inhibitor DMA7GTH RN Synthesis and pharmacology of site-specific cocaine abuse treatment agents: restricted rotation analogues of methylphenidate. J Med Chem. 2007 May 31;50(11):2718-31. DMA7GTH RU https://pubmed.ncbi.nlm.nih.gov/17489581 DMOE3IJ DI DMOE3IJ DMOE3IJ DN Threo-3-methylglutamate DMOE3IJ MI TT2F078 DMOE3IJ MN Excitatory amino acid transporter 2 (SLC1A2) DMOE3IJ MT DTT DMOE3IJ MA Inhibitor DMOE3IJ RN Contrasting modes of action of methylglutamate derivatives on the excitatory amino acid transporters, EAAT1 and EAAT2. Mol Pharmacol. 1997 May;51(5):809-15. DMOE3IJ RU https://pubmed.ncbi.nlm.nih.gov/9145919 DMOE3IJ DI DMOE3IJ DMOE3IJ DN Threo-3-methylglutamate DMOE3IJ MI TT6KMPN DMOE3IJ MN Excitatory amino acid transporter 4 (SLC1A6) DMOE3IJ MT DTT DMOE3IJ MA Inhibitor DMOE3IJ RN Pharmacological characterization of threo-3-methylglutamic acid with excitatory amino acid transporters in native and recombinant systems. J Neurochem. 2001 Apr;77(2):550-7. DMOE3IJ RU https://pubmed.ncbi.nlm.nih.gov/11299317 DMEVT7S DI DMEVT7S DMEVT7S DN Threo-N-ethylritalinol hydrochloride DMEVT7S MI TTVBI8W DMEVT7S MN Dopamine transporter (DAT) DMEVT7S MT DTT DMEVT7S MA Inhibitor DMEVT7S RN Synthesis and pharmacology of site-specific cocaine abuse treatment agents: restricted rotation analogues of methylphenidate. J Med Chem. 2007 May 31;50(11):2718-31. DMEVT7S RU https://pubmed.ncbi.nlm.nih.gov/17489581 DM4MPVE DI DM4MPVE DM4MPVE DN Threo-ritalinol hydrochloride DM4MPVE MI TTVBI8W DM4MPVE MN Dopamine transporter (DAT) DM4MPVE MT DTT DM4MPVE MA Inhibitor DM4MPVE RN Synthesis and pharmacology of site-specific cocaine abuse treatment agents: restricted rotation analogues of methylphenidate. J Med Chem. 2007 May 31;50(11):2718-31. DM4MPVE RU https://pubmed.ncbi.nlm.nih.gov/17489581 DMV0CZ5 DI DMV0CZ5 DMV0CZ5 DN Threo-ritalinol methyl ether hydrochloride DMV0CZ5 MI TTVBI8W DMV0CZ5 MN Dopamine transporter (DAT) DMV0CZ5 MT DTT DMV0CZ5 MA Inhibitor DMV0CZ5 RN Synthesis and pharmacology of site-specific cocaine abuse treatment agents: restricted rotation analogues of methylphenidate. J Med Chem. 2007 May 31;50(11):2718-31. DMV0CZ5 RU https://pubmed.ncbi.nlm.nih.gov/17489581 DMRVXH7 DI DMRVXH7 DMRVXH7 DN ThromboMer DMRVXH7 MI TTIHYA4 DMRVXH7 MN Thrombopoietin receptor (MPL) DMRVXH7 MT DTT DMRVXH7 MA Modulator DMRVXH7 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1722). DMRVXH7 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1722 DMY07CA DI DMY07CA DMY07CA DN THRX160209 DMY07CA MI TTOXS3C DMY07CA MN Muscarinic acetylcholine receptor (CHRM) DMY07CA MT DTT DMY07CA MA Antagonist DMY07CA RN A novel multivalent ligand that bridges the allosteric and orthosteric binding sites of the M2 muscarinic receptor. Mol Pharmacol. 2007 Aug;72(2):291-302. DMY07CA RU https://pubmed.ncbi.nlm.nih.gov/17478612 DMUDGSN DI DMUDGSN DMUDGSN DN THYMELEATOXIN DMUDGSN MI TT9WJ8U DMUDGSN MN Protein kinase C delta (PRKCD) DMUDGSN MT DTT DMUDGSN MA Inhibitor DMUDGSN RN Structural basis of binding of high-affinity ligands to protein kinase C: prediction of the binding modes through a new molecular dynamics method a... J Med Chem. 2001 May 24;44(11):1690-701. DMUDGSN RU https://pubmed.ncbi.nlm.nih.gov/11356104 DMKM6NQ DI DMKM6NQ DMKM6NQ DN Thymidine-5'-Phosphate DMKM6NQ MI TTU6BFZ DMKM6NQ MN Candida Thymidylate synthase (Candi TMP1) DMKM6NQ MT DTT DMKM6NQ MA Inhibitor DMKM6NQ RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMKM6NQ RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMKM6NQ DI DMKM6NQ DMKM6NQ DN Thymidine-5'-Phosphate DMKM6NQ MI TT5B8AX DMKM6NQ MN Mycobacterium Thymidine monophosphate kinase (MycB tmk) DMKM6NQ MT DTT DMKM6NQ MA Inhibitor DMKM6NQ RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMKM6NQ RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMKM6NQ DI DMKM6NQ DMKM6NQ DN Thymidine-5'-Phosphate DMKM6NQ MI TTP3QRF DMKM6NQ MN Thymidine kinase 1 (TK1) DMKM6NQ MT DTT DMKM6NQ MA Inhibitor DMKM6NQ RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMKM6NQ RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMKGXB9 DI DMKGXB9 DMKGXB9 DN Thymine DMKGXB9 MI TTO0IB8 DMKGXB9 MN Thymidine phosphorylase (TYMP) DMKGXB9 MT DTT DMKGXB9 MA Inhibitor DMKGXB9 RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMKGXB9 RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMU10FE DI DMU10FE DMU10FE DN THZ1 DMU10FE MI TTQYF7G DMU10FE MN Cyclin-dependent kinase 7 (CDK7) DMU10FE MT DTT DMU10FE MA Inhibitor DMU10FE RN Targeting transcription regulation in cancer with a covalent CDK7 inhibitor. Nature. 2014 Jul 31;511(7511):616-20. DMU10FE RU https://pubmed.ncbi.nlm.nih.gov/25043025 DMBZ2MF DI DMBZ2MF DMBZ2MF DN THZ531 DMBZ2MF MI TTJ21A9 DMBZ2MF MN Cyclin-dependent kinase 12 (CDK12) DMBZ2MF MT DTT DMBZ2MF MA Inhibitor DMBZ2MF RN Covalent targeting of remote cysteine residues to develop CDK12 and CDK13 inhibitors. Nat Chem Biol. 2016 Oct;12(10):876-84. DMBZ2MF RU https://pubmed.ncbi.nlm.nih.gov/27571479 DMBZ2MF DI DMBZ2MF DMBZ2MF DN THZ531 DMBZ2MF MI TTRIM0E DMBZ2MF MN Cyclin-dependent kinase 13 (CDK13) DMBZ2MF MT DTT DMBZ2MF MA Inhibitor DMBZ2MF RN Covalent targeting of remote cysteine residues to develop CDK12 and CDK13 inhibitors. Nat Chem Biol. 2016 Oct;12(10):876-84. DMBZ2MF RU https://pubmed.ncbi.nlm.nih.gov/27571479 DMGXSTB DI DMGXSTB DMGXSTB DN TI3 DMGXSTB MI TTVDSZ0 DMGXSTB MN Poly [ADP-ribose] polymerase 1 (PARP1) DMGXSTB MT DTT DMGXSTB MA Inhibitor DMGXSTB RN Identification of potent nontoxic poly(ADP-Ribose) polymerase-1 inhibitors: chemopotentiation and pharmacological studies. Clin Cancer Res. 2003 Jul;9(7):2711-8. DMGXSTB RU https://pubmed.ncbi.nlm.nih.gov/12855651 DMOXINT DI DMOXINT DMOXINT DN TI4 DMOXINT MI TTVDSZ0 DMOXINT MN Poly [ADP-ribose] polymerase 1 (PARP1) DMOXINT MT DTT DMOXINT MA Inhibitor DMOXINT RN Identification of potent nontoxic poly(ADP-Ribose) polymerase-1 inhibitors: chemopotentiation and pharmacological studies. Clin Cancer Res. 2003 Jul;9(7):2711-8. DMOXINT RU https://pubmed.ncbi.nlm.nih.gov/12855651 DMWSI0H DI DMWSI0H DMWSI0H DN Tiapamil DMWSI0H MI DTUGYRD DMWSI0H MN P-glycoprotein 1 (ABCB1) DMWSI0H MT DTP DMWSI0H MA Substrate DMWSI0H RN Mammalian drug efflux transporters of the ATP binding cassette (ABC) family in multidrug resistance: A review of the past decade. Cancer Lett. 2016 Jan 1;370(1):153-64. DMWSI0H RU http://www.ncbi.nlm.nih.gov/pubmed/26499806 DMEFVPH DI DMEFVPH DMEFVPH DN Tiazofurin adenine dinucleotide DMEFVPH MI TTZFTY4 DMEFVPH MN Amidophosphoribosyltransferase (PPAT) DMEFVPH MT DTT DMEFVPH MA Inhibitor DMEFVPH RN Dual inhibitors of inosine monophosphate dehydrogenase and histone deacetylases for cancer treatment. J Med Chem. 2007 Dec 27;50(26):6685-91. DMEFVPH RU https://pubmed.ncbi.nlm.nih.gov/18038969 DMEFVPH DI DMEFVPH DMEFVPH DN Tiazofurin adenine dinucleotide DMEFVPH MI TTTB4UP DMEFVPH MN Inosine-5'-monophosphate dehydrogenase 2 (IMPDH2) DMEFVPH MT DTT DMEFVPH MA Inhibitor DMEFVPH RN Dual inhibitors of inosine monophosphate dehydrogenase and histone deacetylases for cancer treatment. J Med Chem. 2007 Dec 27;50(26):6685-91. DMEFVPH RU https://pubmed.ncbi.nlm.nih.gov/18038969 DMMFCHU DI DMMFCHU DMMFCHU DN Tic-D-Phe-Arg-2-Nal-NHCH3 DMMFCHU MI TT0MV2T DMMFCHU MN Melanocortin receptor 1 (MC1R) DMMFCHU MT DTT DMMFCHU MA Inhibitor DMMFCHU RN Synthesis of Tic-D-Phe Psi[CH2-CH2] isostere and its use in the development of melanocortin receptor agonists. Bioorg Med Chem Lett. 2006 Mar 15;16(6):1721-5. DMMFCHU RU https://pubmed.ncbi.nlm.nih.gov/16376076 DMMFCHU DI DMMFCHU DMMFCHU DN Tic-D-Phe-Arg-2-Nal-NHCH3 DMMFCHU MI TTNI91K DMMFCHU MN Melanocortin receptor 3 (MC3R) DMMFCHU MT DTT DMMFCHU MA Inhibitor DMMFCHU RN Synthesis of Tic-D-Phe Psi[CH2-CH2] isostere and its use in the development of melanocortin receptor agonists. Bioorg Med Chem Lett. 2006 Mar 15;16(6):1721-5. DMMFCHU RU https://pubmed.ncbi.nlm.nih.gov/16376076 DMMFCHU DI DMMFCHU DMMFCHU DN Tic-D-Phe-Arg-2-Nal-NHCH3 DMMFCHU MI TTD0CIQ DMMFCHU MN Melanocortin receptor 4 (MC4R) DMMFCHU MT DTT DMMFCHU MA Inhibitor DMMFCHU RN Synthesis of Tic-D-Phe Psi[CH2-CH2] isostere and its use in the development of melanocortin receptor agonists. Bioorg Med Chem Lett. 2006 Mar 15;16(6):1721-5. DMMFCHU RU https://pubmed.ncbi.nlm.nih.gov/16376076 DM71HQL DI DM71HQL DM71HQL DN Tideglusib DM71HQL MI TTNHMO8 DM71HQL MN COVID-19 papain-like proteinase (PL-PRO) DM71HQL MT DTT DM71HQL MA Inhibitor DM71HQL RN Structure of Mpro from COVID-19 virus and discovery of its inhibitors. Nature. 2020 Apr 9. DM71HQL RU https://pubmed.ncbi.nlm.nih.gov/32272481 DM4QK0T DI DM4QK0T DM4QK0T DN tifluadom DM4QK0T MI TTQW87Y DM4QK0T MN Opioid receptor kappa (OPRK1) DM4QK0T MT DTT DM4QK0T MA Agonist DM4QK0T RN Activation of the cloned human kappa opioid receptor by agonists enhances [35S]GTPgammaS binding to membranes: determination of potencies and efficacies of ligands. J Pharmacol Exp Ther. 1997 Aug;282(2):676-84. DM4QK0T RU https://pubmed.ncbi.nlm.nih.gov/9262330 DMLNTB5 DI DMLNTB5 DMLNTB5 DN TILIROSIDE DMLNTB5 MI TTXV4FI DMLNTB5 MN Albendazole monooxygenase (CYP3A4) DMLNTB5 MT DTT DMLNTB5 MA Inhibitor DMLNTB5 RN Isolation of cytochrome P450 inhibitors from strawberry fruit, Fragaria ananassa. J Nat Prod. 2004 Nov;67(11):1839-41. DMLNTB5 RU https://pubmed.ncbi.nlm.nih.gov/15568772 DMTXJ5S DI DMTXJ5S DMTXJ5S DN Tin protoporphyrin DMTXJ5S MI TTI6V2A DMTXJ5S MN Heme oxygenase 1 (HMOX1) DMTXJ5S MT DTT DMTXJ5S MA Inhibitor DMTXJ5S RN Adenovirus-mediated heme oxygenase-1 gene delivery inhibits injury-induced vascular neointima formation. Circulation. 2001 Nov 27;104(22):2710-5. DMTXJ5S RU https://pubmed.ncbi.nlm.nih.gov/11723024 DMEV7FY DI DMEV7FY DMEV7FY DN TINGENIN B DMEV7FY MI TTFBNVI DMEV7FY MN Aldose reductase (AKR1B1) DMEV7FY MT DTT DMEV7FY MA Inhibitor DMEV7FY RN Structures of new friedelane-type triterpenes and eudesmane-type sesquiterpene and aldose reductase inhibitors from Salacia chinensis. J Nat Prod. 2003 Sep;66(9):1191-6. DMEV7FY RU https://pubmed.ncbi.nlm.nih.gov/14510595 DMH3NTP DI DMH3NTP DMH3NTP DN TINGENONE DMH3NTP MI TTFBNVI DMH3NTP MN Aldose reductase (AKR1B1) DMH3NTP MT DTT DMH3NTP MA Inhibitor DMH3NTP RN Structures of new friedelane-type triterpenes and eudesmane-type sesquiterpene and aldose reductase inhibitors from Salacia chinensis. J Nat Prod. 2003 Sep;66(9):1191-6. DMH3NTP RU https://pubmed.ncbi.nlm.nih.gov/14510595 DM81KD2 DI DM81KD2 DM81KD2 DN tiotidine DM81KD2 MI TTQHJ1K DM81KD2 MN Histamine H2 receptor (H2R) DM81KD2 MT DTT DM81KD2 MA Antagonist DM81KD2 RN Heterologous expression of rat epitope-tagged histamine H2 receptors in insect Sf9 cells. Br J Pharmacol. 1997 Nov;122(5):867-74. DM81KD2 RU https://pubmed.ncbi.nlm.nih.gov/9384502 DMZO1FJ DI DMZO1FJ DMZO1FJ DN TIP DMZO1FJ MI TT27RFC DMZO1FJ MN Opioid receptor delta (OPRD1) DMZO1FJ MT DTT DMZO1FJ MA Antagonist DMZO1FJ RN The TIPP opioid peptide family: development of delta antagonists, delta agonists, and mixed mu agonist/delta antagonists. Biopolymers. 1999;51(6):411-25. DMZO1FJ RU https://pubmed.ncbi.nlm.nih.gov/10797230 DM9FNQ6 DI DM9FNQ6 DM9FNQ6 DN TIPPpsi DM9FNQ6 MI TT27RFC DM9FNQ6 MN Opioid receptor delta (OPRD1) DM9FNQ6 MT DTT DM9FNQ6 MA Antagonist DM9FNQ6 RN TIPP[psi]: a highly potent and stable pseudopeptide delta opioid receptor antagonist with extraordinary delta selectivity. J Med Chem. 1993 Oct 15;36(21):3182-7. DM9FNQ6 RU https://pubmed.ncbi.nlm.nih.gov/8230106 DMQ4GBO DI DMQ4GBO DMQ4GBO DN tirotundin DMQ4GBO MI TTT2SVW DMQ4GBO MN PPAR-gamma messenger RNA (PPARG mRNA) DMQ4GBO MT DTT DMQ4GBO MA Agonist DMQ4GBO RN Sesquiterpene lactones from Tithonia diversifolia act as peroxisome proliferator-activated receptor agonists. Bioorg Med Chem Lett. 2012 Apr 15;22(8):2954-8. DMQ4GBO RU https://pubmed.ncbi.nlm.nih.gov/22424975 DMKV52P DI DMKV52P DMKV52P DN TK-112690 DMKV52P MI TT9TQRP DMKV52P MN Uridine phosphorylase (UPP) DMKV52P MT DTT DMKV52P MA Modulator DMKV52P RN CN patent application no. 102014919, Methotrexate adjuvants to reduce toxicity and methods for using the same. DMKV52P RU http://www.google.com/patents/CN102014919B?cl=en DMYGXHK DI DMYGXHK DMYGXHK DN T-kinin DMYGXHK MI TTGY8IW DMYGXHK MN B2 bradykinin receptor (BDKRB2) DMYGXHK MT DTT DMYGXHK MA Agonist DMYGXHK RN Molecular characterisation of cloned bradykinin B1 receptors from rat and human. Eur J Pharmacol. 1999 Jun 25;374(3):423-33. DMYGXHK RU https://pubmed.ncbi.nlm.nih.gov/10422787 DMDBUXR DI DMDBUXR DMDBUXR DN TKP-1001 DMDBUXR MI TTE4KHA DMDBUXR MN Amyloid beta A4 protein (APP) DMDBUXR MT DTT DMDBUXR MA Modulator DMDBUXR RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2402). DMDBUXR RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2402 DMZU4O8 DI DMZU4O8 DMZU4O8 DN TKP-1002 DMZU4O8 MI TTE0A2F DMZU4O8 MN Dopamine D4 receptor (D4R) DMZU4O8 MT DTT DMZU4O8 MA Modulator DMZU4O8 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 217). DMZU4O8 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=217 DMAHG9E DI DMAHG9E DMAHG9E DN TL-1892 DMAHG9E MI TTYFKSZ DMAHG9E MN Tubulin beta (TUBB) DMAHG9E MT DTT DMAHG9E MA Inhibitor DMAHG9E RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2640). DMAHG9E RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2640 DMCN2B8 DI DMCN2B8 DMCN2B8 DN TMB-8 DMCN2B8 MI TTPC4TU DMCN2B8 MN 5-HT 3A receptor (HTR3A) DMCN2B8 MT DTT DMCN2B8 MA Blocker (channel blocker) DMCN2B8 RN Characterization of interaction of 3,4,5-trimethoxybenzoic acid 8-(diethylamino)octyl ester with Torpedo californica nicotinic acetylcholine receptor and 5-hydroxytryptamine3 receptor. J Pharmacol Exp Ther. 1999 Jul;290(1):129-35. DMCN2B8 RU https://pubmed.ncbi.nlm.nih.gov/10381768 DMSMQE7 DI DMSMQE7 DMSMQE7 DN TMP269 DMSMQE7 MI TTTQGH8 DMSMQE7 MN Histone deacetylase 4 (HDAC4) DMSMQE7 MT DTT DMSMQE7 MA Inhibitor DMSMQE7 RN Selective class IIa histone deacetylase inhibition via a nonchelating zinc-binding group. Nat Chem Biol. 2013 May;9(5):319-25. DMSMQE7 RU https://pubmed.ncbi.nlm.nih.gov/23524983 DMSMQE7 DI DMSMQE7 DMSMQE7 DN TMP269 DMSMQE7 MI TTUELN5 DMSMQE7 MN Histone deacetylase 5 (HDAC5) DMSMQE7 MT DTT DMSMQE7 MA Inhibitor DMSMQE7 RN Selective class IIa histone deacetylase inhibition via a nonchelating zinc-binding group. Nat Chem Biol. 2013 May;9(5):319-25. DMSMQE7 RU https://pubmed.ncbi.nlm.nih.gov/23524983 DMSMQE7 DI DMSMQE7 DMSMQE7 DN TMP269 DMSMQE7 MI TTMUEK1 DMSMQE7 MN Histone deacetylase 7 (HDAC7) DMSMQE7 MT DTT DMSMQE7 MA Inhibitor DMSMQE7 RN Selective class IIa histone deacetylase inhibition via a nonchelating zinc-binding group. Nat Chem Biol. 2013 May;9(5):319-25. DMSMQE7 RU https://pubmed.ncbi.nlm.nih.gov/23524983 DMSMQE7 DI DMSMQE7 DMSMQE7 DN TMP269 DMSMQE7 MI TT8M4E1 DMSMQE7 MN Histone deacetylase 9 (HDAC9) DMSMQE7 MT DTT DMSMQE7 MA Inhibitor DMSMQE7 RN Selective class IIa histone deacetylase inhibition via a nonchelating zinc-binding group. Nat Chem Biol. 2013 May;9(5):319-25. DMSMQE7 RU https://pubmed.ncbi.nlm.nih.gov/23524983 DMWO85H DI DMWO85H DMWO85H DN TMPyP4 DMWO85H MI TTUJFD0 DMWO85H MN Telomerase reverse transcriptase (TERT) DMWO85H MT DTT DMWO85H MA Inhibitor DMWO85H RN Emerging therapies for multiple myeloma. Expert Opin Emerg Drugs. 2009 Mar;14(1):99-127. DMWO85H RU https://pubmed.ncbi.nlm.nih.gov/19249983 DMULO0V DI DMULO0V DMULO0V DN TMX-201 DMULO0V MI TTRJ1K4 DMULO0V MN Toll-like receptor 7 (TLR7) DMULO0V MT DTT DMULO0V RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1757). DMULO0V RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1757 DMPX3WT DI DMPX3WT DMPX3WT DN TMX-202 DMPX3WT MI TTRJ1K4 DMPX3WT MN Toll-like receptor 7 (TLR7) DMPX3WT MT DTT DMPX3WT MA Agonist DMPX3WT RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1757). DMPX3WT RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1757 DMSEAMU DI DMSEAMU DMSEAMU DN TMX-30X DMSEAMU MI TTRJ1K4 DMSEAMU MN Toll-like receptor 7 (TLR7) DMSEAMU MT DTT DMSEAMU MA Agonist DMSEAMU RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1757). DMSEAMU RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1757 DME0I7O DI DME0I7O DME0I7O DN TN-14003 DME0I7O MI TTBID49 DME0I7O MN C-X-C chemokine receptor type 4 (CXCR4) DME0I7O MT DTT DME0I7O MA Inhibitor DME0I7O RN Discovery of small molecule CXCR4 antagonists. J Med Chem. 2007 Nov 15;50(23):5655-64. DME0I7O RU https://pubmed.ncbi.nlm.nih.gov/17958344 DMAGI7K DI DMAGI7K DMAGI7K DN TNFcept DMAGI7K MI TTG043C DMAGI7K MN Tumor necrosis factor receptor type I (TNF-R1) DMAGI7K MT DTT DMAGI7K MA Modulator DMAGI7K RN Secretion of a TNFR:Fc fusion protein following pulmonary administration of pseudotyped adeno-associated virus vectors. J Virol. 2004 Nov;78(22):12355-65. DMAGI7K RU https://pubmed.ncbi.nlm.nih.gov/15507622 DM4T0ZF DI DM4T0ZF DM4T0ZF DN TNFmab DM4T0ZF MI TTG043C DM4T0ZF MN Tumor necrosis factor receptor type I (TNF-R1) DM4T0ZF MT DTT DM4T0ZF RN Secretion of a TNFR:Fc fusion protein following pulmonary administration of pseudotyped adeno-associated virus vectors. J Virol. 2004 Nov;78(22):12355-65. DM4T0ZF RU https://pubmed.ncbi.nlm.nih.gov/15507622 DMPTQEG DI DMPTQEG DMPTQEG DN TNFR1 NAM DMPTQEG MI TTG043C DMPTQEG MN Tumor necrosis factor receptor type I (TNF-R1) DMPTQEG MT DTT DMPTQEG MA Modulator DMPTQEG RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1870). DMPTQEG RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1870 DMC958O DI DMC958O DMC958O DN TNK-651 DMC958O MI TT84ETX DMC958O MN Human immunodeficiency virus Reverse transcriptase (HIV RT) DMC958O MT DTT DMC958O MA Modulator DMC958O RN Synthesis and Antiviral Evaluation of 1-[(2-Phenoxyethyl)oxymethyl] and 6-(3,5-Dimethoxybenzyl) Analogues of HIV Drugs Emivirine and TNK-651.Drug Res (Stuttg).2016 Apr;66(4):181-8. DMC958O RU https://www.ncbi.nlm.nih.gov/pubmed/26313923 DMVZY0X DI DMVZY0X DMVZY0X DN TNP-ATP DMVZY0X MI TTJW7B3 DMVZY0X MN P2X purinoceptor 1 (P2RX1) DMVZY0X MT DTT DMVZY0X MA Antagonist DMVZY0X RN Trinitrophenyl-substituted nucleotides are potent antagonists selective for P2X1, P2X3, and heteromeric P2X2/3 receptors. Mol Pharmacol. 1998 Jun;53(6):969-73. DMVZY0X RU https://pubmed.ncbi.nlm.nih.gov/9614197 DMVZY0X DI DMVZY0X DMVZY0X DN TNP-ATP DMVZY0X MI TT2THBD DMVZY0X MN P2X purinoceptor 3 (P2RX3) DMVZY0X MT DTT DMVZY0X MA Antagonist DMVZY0X RN Trinitrophenyl-substituted nucleotides are potent antagonists selective for P2X1, P2X3, and heteromeric P2X2/3 receptors. Mol Pharmacol. 1998 Jun;53(6):969-73. DMVZY0X RU https://pubmed.ncbi.nlm.nih.gov/9614197 DMHV5NK DI DMHV5NK DMHV5NK DN TOLOXATONE DMHV5NK MI TT3WG5C DMHV5NK MN Monoamine oxidase type A (MAO-A) DMHV5NK MT DTT DMHV5NK MA Inhibitor DMHV5NK RN Quercetin as the active principle of Hypericum hircinum exerts a selective inhibitory activity against MAO-A: extraction, biological analysis, and ... J Nat Prod. 2006 Jun;69(6):945-9. DMHV5NK RU https://pubmed.ncbi.nlm.nih.gov/16792415 DMHV5NK DI DMHV5NK DMHV5NK DN TOLOXATONE DMHV5NK MI TTGP7BY DMHV5NK MN Monoamine oxidase type B (MAO-B) DMHV5NK MT DTT DMHV5NK MA Inhibitor DMHV5NK RN 3-(1H-Pyrrol-1-yl)-2-oxazolidinones as reversible, highly potent, and selective inhibitors of monoamine oxidase type A. J Med Chem. 2002 Mar 14;45(6):1180-3. DMHV5NK RU https://pubmed.ncbi.nlm.nih.gov/11881986 DMPTM6V DI DMPTM6V DMPTM6V DN TOLSERINE DMPTM6V MI TT1RS9F DMPTM6V MN Acetylcholinesterase (AChE) DMPTM6V MT DTT DMPTM6V MA Inhibitor DMPTM6V RN Novel carbamates as orally active acetylcholinesterase inhibitors found to improve scopolamine-induced cognition impairment: pharmacophore-based vi... J Med Chem. 2010 Sep 9;53(17):6490-505. DMPTM6V RU https://pubmed.ncbi.nlm.nih.gov/20684567 DMPTM6V DI DMPTM6V DMPTM6V DN TOLSERINE DMPTM6V MI TTEB0GD DMPTM6V MN Cholinesterase (BCHE) DMPTM6V MT DTT DMPTM6V MA Inhibitor DMPTM6V RN Inhibition of human acetyl- and butyrylcholinesterase by novel carbamates of (-)- and (+)-tetrahydrofurobenzofuran and methanobenzodioxepine. J Med Chem. 2006 Apr 6;49(7):2174-85. DMPTM6V RU https://pubmed.ncbi.nlm.nih.gov/16570913 DMAYUV6 DI DMAYUV6 DMAYUV6 DN Toluene-1-diazonium-3-sulfonic acid anion DMAYUV6 MI TTNJYV2 DMAYUV6 MN Gamma-aminobutyric acid receptor (GAR) DMAYUV6 MT DTT DMAYUV6 MA Inhibitor DMAYUV6 RN Aryl diazo compounds and diazonium salts as potential irreversible probes of the gamma-aminobutyric acid receptor. J Med Chem. 1987 Dec;30(12):2222-7. DMAYUV6 RU https://pubmed.ncbi.nlm.nih.gov/2824775 DMA3U15 DI DMA3U15 DMA3U15 DN Tomatine DMA3U15 MI DTF9Y2V DMA3U15 MN ATP-binding cassette sub-family B member 6 (ABCB6) DMA3U15 MT DTP DMA3U15 MA Substrate DMA3U15 RN Efficient purification and reconstitution of ATP binding cassette transporter B6 (ABCB6) for functional and structural studies. J Biol Chem. 2013 Aug 2;288(31):22658-69. DMA3U15 RU http://www.ncbi.nlm.nih.gov/pubmed/23792964 DMROZL8 DI DMROZL8 DMROZL8 DN Tonazocine mesylate DMROZL8 MI TT27RFC DMROZL8 MN Opioid receptor delta (OPRD1) DMROZL8 MT DTT DMROZL8 MA Agonist DMROZL8 RN Antiparkinson potential of delta-opioid receptor agonists. Eur J Pharmacol. 2000 May 19;396(2-3):101-7. DMROZL8 RU https://pubmed.ncbi.nlm.nih.gov/10822062 DMNZQO9 DI DMNZQO9 DMNZQO9 DN TOPOSTATIN DMNZQO9 MI TT2GPK3 DMNZQO9 MN DNA topoisomerase (TOP) DMNZQO9 MT DTT DMNZQO9 MA Inhibitor DMNZQO9 RN Isoaurostatin, a novel topoisomerase inhibitor produced by Thermomonospora alba. J Nat Prod. 2001 Feb;64(2):204-7. DMNZQO9 RU https://pubmed.ncbi.nlm.nih.gov/11430001 DMNZQO9 DI DMNZQO9 DMNZQO9 DN TOPOSTATIN DMNZQO9 MI TTGTQHC DMNZQO9 MN DNA topoisomerase I (TOP1) DMNZQO9 MT DTT DMNZQO9 MA Inhibitor DMNZQO9 RN Isoaurostatin, a novel topoisomerase inhibitor produced by Thermomonospora alba. J Nat Prod. 2001 Feb;64(2):204-7. DMNZQO9 RU https://pubmed.ncbi.nlm.nih.gov/11430001 DMNZQO9 DI DMNZQO9 DMNZQO9 DN TOPOSTATIN DMNZQO9 MI TT0IHXV DMNZQO9 MN DNA topoisomerase II (TOP2) DMNZQO9 MT DTT DMNZQO9 MA Inhibitor DMNZQO9 RN Isoaurostatin, a novel topoisomerase inhibitor produced by Thermomonospora alba. J Nat Prod. 2001 Feb;64(2):204-7. DMNZQO9 RU https://pubmed.ncbi.nlm.nih.gov/11430001 DMKD6GA DI DMKD6GA DMKD6GA DN Toremifene DMKD6GA MI TTC2DS7 DMKD6GA MN COVID-19 non-structural protein 14 (nsp14) DMKD6GA MT DTT DMKD6GA MA Inhibitor DMKD6GA RN Repurposing of FDA-Approved Toremifene to Treat COVID-19 by Blocking the Spike Glycoprotein and NSP14 of SARS-CoV-2. June 5, 2020. DMKD6GA RU https://chemrxiv.org/articles/Repurposing_of_FDA-Approved_Toremifene_to_Treat_COVID-19_by_Blocking_the_Spike_Glycoprotein_and_NSP14_of_SARS-CoV-2/12431966/1 DMKD6GA DI DMKD6GA DMKD6GA DN Toremifene DMKD6GA MI TTZ3COY DMKD6GA MN COVID-19 spike glycoprotein (S) DMKD6GA MT DTT DMKD6GA MA Inhibitor DMKD6GA RN Repurposing of FDA-Approved Toremifene to Treat COVID-19 by Blocking the Spike Glycoprotein and NSP14 of SARS-CoV-2. June 5, 2020. DMKD6GA RU https://chemrxiv.org/articles/Repurposing_of_FDA-Approved_Toremifene_to_Treat_COVID-19_by_Blocking_the_Spike_Glycoprotein_and_NSP14_of_SARS-CoV-2/12431966/1 DMZD0NA DI DMZD0NA DMZD0NA DN torin 1 DMZD0NA MI TTCJG29 DMZD0NA MN Serine/threonine-protein kinase mTOR (mTOR) DMZD0NA MT DTT DMZD0NA MA Inhibitor DMZD0NA RN Discovery of 1-(4-(4-propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-9-(quinolin-3-yl)benzo[h][1,6]naphthyridin-2(1H)-one as a highly potent, selective mammalian target of rapamycin (mTOR) inhibitor for the treatment of cancer. J Med Chem. 2010 Oct 14;53(19):7146-55. DMZD0NA RU https://pubmed.ncbi.nlm.nih.gov/20860370 DMC6U93 DI DMC6U93 DMC6U93 DN Torin2 DMC6U93 MI TTCJG29 DMC6U93 MN Serine/threonine-protein kinase mTOR (mTOR) DMC6U93 MT DTT DMC6U93 MA Inhibitor DMC6U93 RN Torin2 Potentiates Anticancer Effects on Adult T-Cell Leukemia/Lymphoma by Inhibiting Mammalian Target of Rapamycin. Anticancer Res. 2016 Jan;36(1):95-102. DMC6U93 RU https://pubmed.ncbi.nlm.nih.gov/26722032 DMDG0HK DI DMDG0HK DMDG0HK DN Tormentic acid methyl ester DMDG0HK MI TTN7BL9 DMDG0HK MN Corticosteroid 11-beta-dehydrogenase 1 (HSD11B1) DMDG0HK MT DTT DMDG0HK MA Inhibitor DMDG0HK RN 11beta-Hydroxysteroid dehydrogenase 1 inhibiting constituents from Eriobotrya japonica revealed by bioactivity-guided isolation and computational a... Bioorg Med Chem. 2010 Feb 15;18(4):1507-15. DMDG0HK RU https://pubmed.ncbi.nlm.nih.gov/20100662 DMNC2A5 DI DMNC2A5 DMNC2A5 DN Tosyl-D-Proline DMNC2A5 MI TTU6BFZ DMNC2A5 MN Candida Thymidylate synthase (Candi TMP1) DMNC2A5 MT DTT DMNC2A5 MA Inhibitor DMNC2A5 RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMNC2A5 RU https://pubmed.ncbi.nlm.nih.gov/17139284 DM4R657 DI DM4R657 DM4R657 DN toxaphene DM4R657 MI TTPNQAC DM4R657 MN Estrogen-related receptor-alpha (ESRRA) DM4R657 MT DTT DM4R657 MA Antagonist DM4R657 RN Two organochlorine pesticides, toxaphene and chlordane, are antagonists for estrogen-related receptor alpha-1 orphan receptor. Cancer Res. 1999 Sep 15;59(18):4519-24. DM4R657 RU https://pubmed.ncbi.nlm.nih.gov/10493499 DMJHTQK DI DMJHTQK DMJHTQK DN TOXIFERINE DMJHTQK MI TTLA931 DMJHTQK MN Neuronal acetylcholine receptor alpha-7 (CHRNA7) DMJHTQK MT DTT DMJHTQK MA Inhibitor DMJHTQK RN Pharmacological characteristics and binding modes of caracurine V analogues and related compounds at the neuronal alpha7 nicotinic acetylcholine re... J Med Chem. 2007 Sep 20;50(19):4616-29. DMJHTQK RU https://pubmed.ncbi.nlm.nih.gov/17722904 DMRHDGN DI DMRHDGN DMRHDGN DN TP003 DMRHDGN MI TTBMV1G DMRHDGN MN GABA(A) receptor alpha-2 (GABRA2) DMRHDGN MT DTT DMRHDGN MA Modulator (allosteric modulator) DMRHDGN RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 405). DMRHDGN RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=405 DMRHDGN DI DMRHDGN DMRHDGN DN TP003 DMRHDGN MI TT37EDJ DMRHDGN MN GABA(A) receptor alpha-3 (GABRA3) DMRHDGN MT DTT DMRHDGN MA Modulator (allosteric modulator) DMRHDGN RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 406). DMRHDGN RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=406 DMRHDGN DI DMRHDGN DMRHDGN DN TP003 DMRHDGN MI TTNZPQ1 DMRHDGN MN GABA(A) receptor alpha-5 (GABRA5) DMRHDGN MT DTT DMRHDGN MA Modulator (allosteric modulator) DMRHDGN RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 408). DMRHDGN RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=408 DMRHDGN DI DMRHDGN DMRHDGN DN TP003 DMRHDGN MI TTEX6LM DMRHDGN MN GABA(A) receptor gamma-3 (GABRG3) DMRHDGN MT DTT DMRHDGN MA Modulator (allosteric modulator) DMRHDGN RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 415). DMRHDGN RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=415 DMM41O9 DI DMM41O9 DMM41O9 DN TP-680 DMM41O9 MI TTCG0AL DMM41O9 MN Cholecystokinin receptor type A (CCKAR) DMM41O9 MT DTT DMM41O9 MA Antagonist DMM41O9 RN Pharmacological profile of TP-680, a new cholecystokininA receptor antagonist. Br J Pharmacol. 1996 Apr;117(7):1558-64. DMM41O9 RU https://pubmed.ncbi.nlm.nih.gov/8730754 DMM41O9 DI DMM41O9 DMM41O9 DN TP-680 DMM41O9 MI TTVFO0U DMM41O9 MN Gastrin/cholecystokinin type B receptor (CCKBR) DMM41O9 MT DTT DMM41O9 MA Antagonist DMM41O9 RN Pharmacological profile of TP-680, a new cholecystokininA receptor antagonist. Br J Pharmacol. 1996 Apr;117(7):1558-64. DMM41O9 RU https://pubmed.ncbi.nlm.nih.gov/8730754 DM4WTCE DI DM4WTCE DM4WTCE DN TP-801 DM4WTCE MI TTNDSF4 DM4WTCE MN Proto-oncogene c-Met (MET) DM4WTCE MT DTT DM4WTCE MA Inhibitor DM4WTCE RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1815). DM4WTCE RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1815 DMA14PR DI DMA14PR DMA14PR DN TPCA-1 DMA14PR MI TTRPDBG DMA14PR MN Inhibitor of nuclear factor kappa-B kinase (IKK) DMA14PR MT DTT DMA14PR MA Inhibitor DMA14PR RN Attenuation of murine collagen-induced arthritis by a novel, potent, selective small molecule inhibitor of IkappaB Kinase 2, TPCA-1 (2-[(aminocarbo... J Pharmacol Exp Ther. 2005 Jan;312(1):373-81. DMA14PR RU https://pubmed.ncbi.nlm.nih.gov/15316093 DMW2FTP DI DMW2FTP DMW2FTP DN TPI-1361-17 DMW2FTP MI TTX4RTB DMW2FTP MN Melanin-concentrating hormone receptor 1 (MCHR1) DMW2FTP MT DTT DMW2FTP MA Antagonist DMW2FTP RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 280). DMW2FTP RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=280 DMHATCZ DI DMHATCZ DMHATCZ DN Tpl2 kinase inhibitor DMHATCZ MI TTGECUM DMHATCZ MN Cot oncogene messenger RNA (MAP3K8 mRNA) DMHATCZ MT DTT DMHATCZ MA Inhibitor DMHATCZ RN Inhibition of Tpl2 kinase and TNF-alpha production with 1,7-naphthyridine-3-carbonitriles: synthesis and structure-activity relationships. Bioorg Med Chem Lett. 2005 Dec 1;15(23):5288-92. DMHATCZ RU https://pubmed.ncbi.nlm.nih.gov/16165349 DMBF6KS DI DMBF6KS DMBF6KS DN TPMPA DMBF6KS MI TT6XFEU DMBF6KS MN GABA(A) receptor rho1 (GABRR1) DMBF6KS MT DTT DMBF6KS MA Antagonist DMBF6KS RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 420). DMBF6KS RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=420 DMBF6KS DI DMBF6KS DMBF6KS DN TPMPA DMBF6KS MI TTQMXLS DMBF6KS MN GABA(A) receptor rho2 (GABRR2) DMBF6KS MT DTT DMBF6KS MA Antagonist DMBF6KS RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 421). DMBF6KS RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=421 DMBF6KS DI DMBF6KS DMBF6KS DN TPMPA DMBF6KS MI TT4N6D8 DMBF6KS MN GABA(A) receptor rho3 (GABRR3) DMBF6KS MT DTT DMBF6KS MA Antagonist DMBF6KS RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 422). DMBF6KS RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=422 DMW9G7H DI DMW9G7H DMW9G7H DN TPN-729 DMW9G7H MI TTJ0IQB DMW9G7H MN Phosphodiesterase 5A (PDE5A) DMW9G7H MT DTT DMW9G7H MA Inhibitor DMW9G7H RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1304). DMW9G7H RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1304 DMFL5XU DI DMFL5XU DMFL5XU DN TPO gene plasmid DMFL5XU MI TT52XDZ DMFL5XU MN Thyroid peroxidase (TPO) DMFL5XU MT DTT DMFL5XU MA Modulator DMFL5XU RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2526). DMFL5XU RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2526 DMEF32D DI DMEF32D DMEF32D DN TQ-1017 DMEF32D MI TTWJBZ5 DMEF32D MN 5-HT 2C receptor (HTR2C) DMEF32D MT DTT DMEF32D MA Agonist DMEF32D RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015 DMEF32D RU https://www.accessdata.fda.gov/scripts/cder/drugsatfda/ DMEF32D DI DMEF32D DMEF32D DN TQ-1017 DMEF32D MI TTAWNKZ DMEF32D MN Norepinephrine transporter (NET) DMEF32D MT DTT DMEF32D MA Agonist DMEF32D RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015 DMEF32D RU https://www.accessdata.fda.gov/scripts/cder/drugsatfda/ DMEF32D DI DMEF32D DMEF32D DN TQ-1017 DMEF32D MI TTKWM86 DMEF32D MN Opioid receptor mu (MOP) DMEF32D MT DTT DMEF32D MA Agonist DMEF32D RN Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015 DMEF32D RU https://www.accessdata.fda.gov/scripts/cder/drugsatfda/ DMZA6X3 DI DMZA6X3 DMZA6X3 DN TQX-173 DMZA6X3 MI TT0MYE2 DMZA6X3 MN Glutamate receptor ionotropic kainate 1 (GRIK1) DMZA6X3 MT DTT DMZA6X3 MA Inhibitor DMZA6X3 RN Synthesis, ionotropic glutamate receptor binding affinity, and structure-activity relationships of a new set of 4,5-dihydro-8-heteroaryl-4-oxo-1,2,... J Med Chem. 2001 Sep 13;44(19):3157-65. DMZA6X3 RU https://pubmed.ncbi.nlm.nih.gov/11543685 DM18CV3 DI DM18CV3 DM18CV3 DN TRACIZOLINE DM18CV3 MI TTWG9A4 DM18CV3 MN Adrenergic receptor alpha-2A (ADRA2A) DM18CV3 MT DTT DM18CV3 MA Inhibitor DM18CV3 RN Binding of an imidazopyridoindole at imidazoline I2 receptors. Bioorg Med Chem Lett. 2004 Jan 19;14(2):527-9. DM18CV3 RU https://pubmed.ncbi.nlm.nih.gov/14698196 DM18CV3 DI DM18CV3 DM18CV3 DN TRACIZOLINE DM18CV3 MI TTWM4TY DM18CV3 MN Adrenergic receptor alpha-2B (ADRA2B) DM18CV3 MT DTT DM18CV3 MA Inhibitor DM18CV3 RN Binding of an imidazopyridoindole at imidazoline I2 receptors. Bioorg Med Chem Lett. 2004 Jan 19;14(2):527-9. DM18CV3 RU https://pubmed.ncbi.nlm.nih.gov/14698196 DM18CV3 DI DM18CV3 DM18CV3 DN TRACIZOLINE DM18CV3 MI TT2NUT5 DM18CV3 MN Adrenergic receptor alpha-2C (ADRA2C) DM18CV3 MT DTT DM18CV3 MA Inhibitor DM18CV3 RN Binding of an imidazopyridoindole at imidazoline I2 receptors. Bioorg Med Chem Lett. 2004 Jan 19;14(2):527-9. DM18CV3 RU https://pubmed.ncbi.nlm.nih.gov/14698196 DM18CV3 DI DM18CV3 DM18CV3 DN TRACIZOLINE DM18CV3 MI TT3WG5C DM18CV3 MN Monoamine oxidase type A (MAO-A) DM18CV3 MT DTT DM18CV3 MA Inhibitor DM18CV3 RN Binding of an imidazopyridoindole at imidazoline I2 receptors. Bioorg Med Chem Lett. 2004 Jan 19;14(2):527-9. DM18CV3 RU https://pubmed.ncbi.nlm.nih.gov/14698196 DM18CV3 DI DM18CV3 DM18CV3 DN TRACIZOLINE DM18CV3 MI TTGP7BY DM18CV3 MN Monoamine oxidase type B (MAO-B) DM18CV3 MT DTT DM18CV3 MA Inhibitor DM18CV3 RN Binding of an imidazopyridoindole at imidazoline I2 receptors. Bioorg Med Chem Lett. 2004 Jan 19;14(2):527-9. DM18CV3 RU https://pubmed.ncbi.nlm.nih.gov/14698196 DM3ML0N DI DM3ML0N DM3ML0N DN Tramazoline DM3ML0N MI TTWG9A4 DM3ML0N MN Adrenergic receptor alpha-2A (ADRA2A) DM3ML0N MT DTT DM3ML0N MA Inhibitor DM3ML0N RN alpha 2 adrenoceptors: classification, localization, mechanisms, and targets for drugs. J Med Chem. 1982 Dec;25(12):1389-401. DM3ML0N RU https://pubmed.ncbi.nlm.nih.gov/6296387 DM3ML0N DI DM3ML0N DM3ML0N DN Tramazoline DM3ML0N MI TTWM4TY DM3ML0N MN Adrenergic receptor alpha-2B (ADRA2B) DM3ML0N MT DTT DM3ML0N MA Inhibitor DM3ML0N RN alpha 2 adrenoceptors: classification, localization, mechanisms, and targets for drugs. J Med Chem. 1982 Dec;25(12):1389-401. DM3ML0N RU https://pubmed.ncbi.nlm.nih.gov/6296387 DM3ML0N DI DM3ML0N DM3ML0N DN Tramazoline DM3ML0N MI TT2NUT5 DM3ML0N MN Adrenergic receptor alpha-2C (ADRA2C) DM3ML0N MT DTT DM3ML0N MA Inhibitor DM3ML0N RN alpha 2 adrenoceptors: classification, localization, mechanisms, and targets for drugs. J Med Chem. 1982 Dec;25(12):1389-401. DM3ML0N RU https://pubmed.ncbi.nlm.nih.gov/6296387 DMRTASL DI DMRTASL DMRTASL DN Trametinib DMRTASL MI TTAW3TO DMRTASL MN HUMAN ERK activator kinase 1 (MEK1) DMRTASL MT DTT DMRTASL MA Inhibitor DMRTASL RN Coronaviruses - drug discovery and therapeutic options. Nat Rev Drug Discov. 2016 May;15(5):327-47. DMRTASL RU https://pubmed.ncbi.nlm.nih.gov/26868298 DMRTASL DI DMRTASL DMRTASL DN Trametinib DMRTASL MI TTWX403 DMRTASL MN HUMAN ERK activator kinase 2 (MEK2) DMRTASL MT DTT DMRTASL MA Inhibitor DMRTASL RN Coronaviruses - drug discovery and therapeutic options. Nat Rev Drug Discov. 2016 May;15(5):327-47. DMRTASL RU https://pubmed.ncbi.nlm.nih.gov/26868298 DM27TPM DI DM27TPM DM27TPM DN Trans-(+/-)-2-Fluoro-1,2-diphenylcyclopropylamine DM27TPM MI TT3WG5C DM27TPM MN Monoamine oxidase type A (MAO-A) DM27TPM MT DTT DM27TPM MA Inhibitor DM27TPM RN Fluorinated phenylcyclopropylamines. Part 5: Effects of electron-withdrawing or -donating aryl substituents on the inhibition of monoamine oxidases... Bioorg Med Chem. 2008 Aug 1;16(15):7148-66. DM27TPM RU https://pubmed.ncbi.nlm.nih.gov/18640844 DMYVJHN DI DMYVJHN DMYVJHN DN Trans-(1S(R),2S(R))-2-Hydroxycyclooctyl nitrate DMYVJHN MI TTEP6RV DMYVJHN MN Glutathione reductase (GR) DMYVJHN MT DTT DMYVJHN MA Inhibitor DMYVJHN RN In vitro inhibition of human erythrocyte glutathione reductase by some new organic nitrates. Bioorg Med Chem Lett. 2009 Jul 1;19(13):3661-3. DMYVJHN RU https://pubmed.ncbi.nlm.nih.gov/19447620 DMXC98D DI DMXC98D DMXC98D DN Trans-(R(S))-2-Hydroxy-1-phenylethyl nitrate DMXC98D MI TTEP6RV DMXC98D MN Glutathione reductase (GR) DMXC98D MT DTT DMXC98D MA Inhibitor DMXC98D RN In vitro inhibition of human erythrocyte glutathione reductase by some new organic nitrates. Bioorg Med Chem Lett. 2009 Jul 1;19(13):3661-3. DMXC98D RU https://pubmed.ncbi.nlm.nih.gov/19447620 DMHD1XM DI DMHD1XM DMHD1XM DN Trans,trans-1,3-bis-(4-hydroxycyclohexyl)urea DMHD1XM MI TT7WVHI DMHD1XM MN Soluble epoxide hydrolase (EPHX2) DMHD1XM MT DTT DMHD1XM MA Inhibitor DMHD1XM RN Orally bioavailable potent soluble epoxide hydrolase inhibitors. J Med Chem. 2007 Aug 9;50(16):3825-40. DMHD1XM RU https://pubmed.ncbi.nlm.nih.gov/17616115 DMH1S57 DI DMH1S57 DMH1S57 DN Trans-2-(4-chlorophenyl)-2-fluorocyclopropanamine DMH1S57 MI TT3WG5C DMH1S57 MN Monoamine oxidase type A (MAO-A) DMH1S57 MT DTT DMH1S57 MA Inhibitor DMH1S57 RN Fluorinated phenylcyclopropylamines. Part 5: Effects of electron-withdrawing or -donating aryl substituents on the inhibition of monoamine oxidases... Bioorg Med Chem. 2008 Aug 1;16(15):7148-66. DMH1S57 RU https://pubmed.ncbi.nlm.nih.gov/18640844 DMH1S57 DI DMH1S57 DMH1S57 DN Trans-2-(4-chlorophenyl)-2-fluorocyclopropanamine DMH1S57 MI TTGP7BY DMH1S57 MN Monoamine oxidase type B (MAO-B) DMH1S57 MT DTT DMH1S57 MA Inhibitor DMH1S57 RN Fluorinated phenylcyclopropylamines. Part 5: Effects of electron-withdrawing or -donating aryl substituents on the inhibition of monoamine oxidases... Bioorg Med Chem. 2008 Aug 1;16(15):7148-66. DMH1S57 RU https://pubmed.ncbi.nlm.nih.gov/18640844 DMO01T8 DI DMO01T8 DMO01T8 DN Trans-2-fluoro-2-(4-fluorophenyl)cyclopropanamine DMO01T8 MI TT3WG5C DMO01T8 MN Monoamine oxidase type A (MAO-A) DMO01T8 MT DTT DMO01T8 MA Inhibitor DMO01T8 RN Fluorinated phenylcyclopropylamines. Part 5: Effects of electron-withdrawing or -donating aryl substituents on the inhibition of monoamine oxidases... Bioorg Med Chem. 2008 Aug 1;16(15):7148-66. DMO01T8 RU https://pubmed.ncbi.nlm.nih.gov/18640844 DMO01T8 DI DMO01T8 DMO01T8 DN Trans-2-fluoro-2-(4-fluorophenyl)cyclopropanamine DMO01T8 MI TTGP7BY DMO01T8 MN Monoamine oxidase type B (MAO-B) DMO01T8 MT DTT DMO01T8 MA Inhibitor DMO01T8 RN Fluorinated phenylcyclopropylamines. Part 5: Effects of electron-withdrawing or -donating aryl substituents on the inhibition of monoamine oxidases... Bioorg Med Chem. 2008 Aug 1;16(15):7148-66. DMO01T8 RU https://pubmed.ncbi.nlm.nih.gov/18640844 DMVGAFR DI DMVGAFR DMVGAFR DN Trans-2-fluoro-2-phenylcyclopropylamin DMVGAFR MI TT3WG5C DMVGAFR MN Monoamine oxidase type A (MAO-A) DMVGAFR MT DTT DMVGAFR MA Inhibitor DMVGAFR RN Fluorinated phenylcyclopropylamines. Part 5: Effects of electron-withdrawing or -donating aryl substituents on the inhibition of monoamine oxidases... Bioorg Med Chem. 2008 Aug 1;16(15):7148-66. DMVGAFR RU https://pubmed.ncbi.nlm.nih.gov/18640844 DMVGAFR DI DMVGAFR DMVGAFR DN Trans-2-fluoro-2-phenylcyclopropylamin DMVGAFR MI TTGP7BY DMVGAFR MN Monoamine oxidase type B (MAO-B) DMVGAFR MT DTT DMVGAFR MA Inhibitor DMVGAFR RN Fluorinated phenylcyclopropylamines. Part 5: Effects of electron-withdrawing or -donating aryl substituents on the inhibition of monoamine oxidases... Bioorg Med Chem. 2008 Aug 1;16(15):7148-66. DMVGAFR RU https://pubmed.ncbi.nlm.nih.gov/18640844 DM392QT DI DM392QT DM392QT DN Trans-2-fluoro-2-p-tolylcyclopropanamine DM392QT MI TT3WG5C DM392QT MN Monoamine oxidase type A (MAO-A) DM392QT MT DTT DM392QT MA Inhibitor DM392QT RN Fluorinated phenylcyclopropylamines. Part 5: Effects of electron-withdrawing or -donating aryl substituents on the inhibition of monoamine oxidases... Bioorg Med Chem. 2008 Aug 1;16(15):7148-66. DM392QT RU https://pubmed.ncbi.nlm.nih.gov/18640844 DM392QT DI DM392QT DM392QT DN Trans-2-fluoro-2-p-tolylcyclopropanamine DM392QT MI TTGP7BY DM392QT MN Monoamine oxidase type B (MAO-B) DM392QT MT DTT DM392QT MA Inhibitor DM392QT RN Fluorinated phenylcyclopropylamines. Part 5: Effects of electron-withdrawing or -donating aryl substituents on the inhibition of monoamine oxidases... Bioorg Med Chem. 2008 Aug 1;16(15):7148-66. DM392QT RU https://pubmed.ncbi.nlm.nih.gov/18640844 DMHJM0B DI DMHJM0B DMHJM0B DN trans-2-methylcrotonic acid DMHJM0B MI TT0FYAN DMHJM0B MN Free fatty acid receptor 2 (FFAR2) DMHJM0B MT DTT DMHJM0B MA Agonist DMHJM0B RN Selective orthosteric free fatty acid receptor 2 (FFA2) agonists: identification of the structural and chemical requirements for selective activation of FFA2 versus FFA3. J Biol Chem. 2011 Mar 25;286(12):10628-40. DMHJM0B RU https://pubmed.ncbi.nlm.nih.gov/21220428 DMEDC5I DI DMEDC5I DMEDC5I DN Trans-3-(o-tolyloxy)-2,3-dihydro-1H-inden-1-amine DMEDC5I MI TTVBI8W DMEDC5I MN Dopamine transporter (DAT) DMEDC5I MT DTT DMEDC5I MA Inhibitor DMEDC5I RN Discovery of a potent, selective, and less flexible selective norepinephrine reuptake inhibitor (sNRI). Bioorg Med Chem Lett. 2008 Jul 15;18(14):4224-7. DMEDC5I RU https://pubmed.ncbi.nlm.nih.gov/18550369 DMEDC5I DI DMEDC5I DMEDC5I DN Trans-3-(o-tolyloxy)-2,3-dihydro-1H-inden-1-amine DMEDC5I MI TTAWNKZ DMEDC5I MN Norepinephrine transporter (NET) DMEDC5I MT DTT DMEDC5I MA Inhibitor DMEDC5I RN Discovery of a potent, selective, and less flexible selective norepinephrine reuptake inhibitor (sNRI). Bioorg Med Chem Lett. 2008 Jul 15;18(14):4224-7. DMEDC5I RU https://pubmed.ncbi.nlm.nih.gov/18550369 DMEDC5I DI DMEDC5I DMEDC5I DN Trans-3-(o-tolyloxy)-2,3-dihydro-1H-inden-1-amine DMEDC5I MI TT3ROYC DMEDC5I MN Serotonin transporter (SERT) DMEDC5I MT DTT DMEDC5I MA Inhibitor DMEDC5I RN Discovery of a potent, selective, and less flexible selective norepinephrine reuptake inhibitor (sNRI). Bioorg Med Chem Lett. 2008 Jul 15;18(14):4224-7. DMEDC5I RU https://pubmed.ncbi.nlm.nih.gov/18550369 DM6HI8W DI DM6HI8W DM6HI8W DN trans-3-ACPBPA DM6HI8W MI TT6XFEU DM6HI8W MN GABA(A) receptor rho1 (GABRR1) DM6HI8W MT DTT DM6HI8W MA Antagonist DM6HI8W RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 420). DM6HI8W RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=420 DM6HI8W DI DM6HI8W DM6HI8W DN trans-3-ACPBPA DM6HI8W MI TTQMXLS DM6HI8W MN GABA(A) receptor rho2 (GABRR2) DM6HI8W MT DTT DM6HI8W MA Antagonist DM6HI8W RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 421). DM6HI8W RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=421 DM6HI8W DI DM6HI8W DM6HI8W DN trans-3-ACPBPA DM6HI8W MI TT4N6D8 DM6HI8W MN GABA(A) receptor rho3 (GABRR3) DM6HI8W MT DTT DM6HI8W MA Antagonist DM6HI8W RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 422). DM6HI8W RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=422 DM8E9YS DI DM8E9YS DM8E9YS DN Trans-dimethyl gababutin DM8E9YS MI TTFK1JQ DM8E9YS MN Voltage-gated calcium channel alpha-2/delta-1 (CACNA2D1) DM8E9YS MT DTT DM8E9YS MA Inhibitor DM8E9YS RN Synthesis and in vivo evaluation of bicyclic gababutins. Bioorg Med Chem Lett. 2010 Jan 15;20(2):461-4. DM8E9YS RU https://pubmed.ncbi.nlm.nih.gov/20005103 DMBU4KJ DI DMBU4KJ DMBU4KJ DN Trans-H-Tyr-c[D-AllylGly-Gly-Phe-D-Allylgly]-OH DMBU4KJ MI TT27RFC DMBU4KJ MN Opioid receptor delta (OPRD1) DMBU4KJ MT DTT DMBU4KJ MA Inhibitor DMBU4KJ RN Synthesis of stable and potent delta/mu opioid peptides: analogues of H-Tyr-c[D-Cys-Gly-Phe-D-Cys]-OH by ring-closing metathesis. J Med Chem. 2007 Jun 28;50(13):3138-42. DMBU4KJ RU https://pubmed.ncbi.nlm.nih.gov/17539621 DMBU4KJ DI DMBU4KJ DMBU4KJ DN Trans-H-Tyr-c[D-AllylGly-Gly-Phe-D-Allylgly]-OH DMBU4KJ MI TTQW87Y DMBU4KJ MN Opioid receptor kappa (OPRK1) DMBU4KJ MT DTT DMBU4KJ MA Inhibitor DMBU4KJ RN Synthesis of stable and potent delta/mu opioid peptides: analogues of H-Tyr-c[D-Cys-Gly-Phe-D-Cys]-OH by ring-closing metathesis. J Med Chem. 2007 Jun 28;50(13):3138-42. DMBU4KJ RU https://pubmed.ncbi.nlm.nih.gov/17539621 DMBU4KJ DI DMBU4KJ DMBU4KJ DN Trans-H-Tyr-c[D-AllylGly-Gly-Phe-D-Allylgly]-OH DMBU4KJ MI TTKWM86 DMBU4KJ MN Opioid receptor mu (MOP) DMBU4KJ MT DTT DMBU4KJ MA Inhibitor DMBU4KJ RN Synthesis of stable and potent delta/mu opioid peptides: analogues of H-Tyr-c[D-Cys-Gly-Phe-D-Cys]-OH by ring-closing metathesis. J Med Chem. 2007 Jun 28;50(13):3138-42. DMBU4KJ RU https://pubmed.ncbi.nlm.nih.gov/17539621 DMXS8LN DI DMXS8LN DMXS8LN DN Trans-hydroxytamoxifen DMXS8LN MI TTZAYWL DMXS8LN MN Estrogen receptor (ESR) DMXS8LN MT DTT DMXS8LN MA Antagonist DMXS8LN RN Antagonists selective for estrogen receptor alpha. Endocrinology. 2002 Mar;143(3):941-7. DMXS8LN RU https://pubmed.ncbi.nlm.nih.gov/11861516 DMXS8LN DI DMXS8LN DMXS8LN DN Trans-hydroxytamoxifen DMXS8LN MI TTOM3J0 DMXS8LN MN Estrogen receptor beta (ESR2) DMXS8LN MT DTT DMXS8LN MA Antagonist DMXS8LN RN Antagonists selective for estrogen receptor alpha. Endocrinology. 2002 Mar;143(3):941-7. DMXS8LN RU https://pubmed.ncbi.nlm.nih.gov/11861516 DMP4T87 DI DMP4T87 DMP4T87 DN TRANSTORINE DMP4T87 MI TTLD29N DMP4T87 MN Glutamate receptor ionotropic NMDA 1 (NMDAR1) DMP4T87 MT DTT DMP4T87 MA Inhibitor DMP4T87 RN 3-(2-carboxyindol-3-yl)propionic acid derivatives: antagonists of the strychnine-insensitive glycine receptor associated with the N-methyl-D-aspart... J Med Chem. 1990 Nov;33(11):2944-6. DMP4T87 RU https://pubmed.ncbi.nlm.nih.gov/2146391 DMP4T87 DI DMP4T87 DMP4T87 DN TRANSTORINE DMP4T87 MI TTKJEMQ DMP4T87 MN Glutamate receptor ionotropic NMDA 2A (NMDAR2A) DMP4T87 MT DTT DMP4T87 MA Inhibitor DMP4T87 RN 3-(2-carboxyindol-3-yl)propionic acid derivatives: antagonists of the strychnine-insensitive glycine receptor associated with the N-methyl-D-aspart... J Med Chem. 1990 Nov;33(11):2944-6. DMP4T87 RU https://pubmed.ncbi.nlm.nih.gov/2146391 DMP4T87 DI DMP4T87 DMP4T87 DN TRANSTORINE DMP4T87 MI TTN9D8E DMP4T87 MN Glutamate receptor ionotropic NMDA 2B (NMDAR2B) DMP4T87 MT DTT DMP4T87 MA Inhibitor DMP4T87 RN 3-(2-carboxyindol-3-yl)propionic acid derivatives: antagonists of the strychnine-insensitive glycine receptor associated with the N-methyl-D-aspart... J Med Chem. 1990 Nov;33(11):2944-6. DMP4T87 RU https://pubmed.ncbi.nlm.nih.gov/2146391 DMXZAH6 DI DMXZAH6 DMXZAH6 DN Trapoxin DMXZAH6 MI TTBH0VX DMXZAH6 MN Histone deacetylase (HDAC) DMXZAH6 MT DTT DMXZAH6 MA Inhibitor DMXZAH6 RN Histone deacetylase as a new target for cancer chemotherapy. Cancer Chemother Pharmacol. 2001 Aug;48 Suppl 1:S20-6. DMXZAH6 RU https://pubmed.ncbi.nlm.nih.gov/11587361 DMDX0VI DI DMDX0VI DMDX0VI DN Trecadrine DMDX0VI MI TTMXGCW DMDX0VI MN Adrenergic receptor beta-3 (ADRB3) DMDX0VI MT DTT DMDX0VI MA Agonist DMDX0VI RN Potential anti-diabetic applications of a new molecule with affinity for beta 3-adrenoceptors. Life Sci. 1996;59(11):PL141-6. DMDX0VI RU https://pubmed.ncbi.nlm.nih.gov/8795708 DMDX0VI DI DMDX0VI DMDX0VI DN Trecadrine DMDX0VI MI TTHQPL7 DMDX0VI MN Carbonic anhydrase I (CA-I) DMDX0VI MT DTT DMDX0VI MA Inhibitor DMDX0VI RN Sulfenamido-sulfonamides as inhibitors of carbonic anhydrase isozymes I, II and IV. J Enzyme Inhib. 1997 Aug;12(3):175-90. DMDX0VI RU https://pubmed.ncbi.nlm.nih.gov/9314114 DMDX0VI DI DMDX0VI DMDX0VI DN Trecadrine DMDX0VI MI TTANPDJ DMDX0VI MN Carbonic anhydrase II (CA-II) DMDX0VI MT DTT DMDX0VI MA Inhibitor DMDX0VI RN Sulfenamido-sulfonamides as inhibitors of carbonic anhydrase isozymes I, II and IV. J Enzyme Inhib. 1997 Aug;12(3):175-90. DMDX0VI RU https://pubmed.ncbi.nlm.nih.gov/9314114 DMDX0VI DI DMDX0VI DMDX0VI DN Trecadrine DMDX0VI MI TTZHA0O DMDX0VI MN Carbonic anhydrase IV (CA-IV) DMDX0VI MT DTT DMDX0VI MA Inhibitor DMDX0VI RN Sulfenamido-sulfonamides as inhibitors of carbonic anhydrase isozymes I, II and IV. J Enzyme Inhib. 1997 Aug;12(3):175-90. DMDX0VI RU https://pubmed.ncbi.nlm.nih.gov/9314114 DME94KO DI DME94KO DME94KO DN Trecetilide fumarate DME94KO MI TT1VOHK DME94KO MN Potassium channel unspecific (KC) DME94KO MT DTT DME94KO MA Blocker DME94KO RN IKr channel blockers: novel antiarrhythmic agents. Curr Med Chem Cardiovasc Hematol Agents. 2003 Oct;1(3):203-23. DME94KO RU https://pubmed.ncbi.nlm.nih.gov/15326913 DM8LYSB DI DM8LYSB DM8LYSB DN Triazine DM8LYSB MI TT3PQ2Y DM8LYSB MN Plasmodium Dihydroorotate dehydrogenase (Malaria DHOdehase) DM8LYSB MT DTT DM8LYSB MA Inhibitor DM8LYSB RN Kinetics of inhibition of human and rat dihydroorotate dehydrogenase by atovaquone, lawsone derivatives, brequinar sodium and polyporic acid. Chem Biol Interact. 2000 Jan 3;124(1):61-76. DM8LYSB RU https://pubmed.ncbi.nlm.nih.gov/10658902 DMCLA2D DI DMCLA2D DMCLA2D DN triazine compound PC10 DMCLA2D MI TTM67AX DMCLA2D MN Prokineticin receptor 2 (PKR2) DMCLA2D MT DTT DMCLA2D MA Antagonist DMCLA2D RN Prokineticin receptor 1 antagonist PC-10 as a biomarker for imaging inflammatory pain. J Nucl Med. 2011 Apr;52(4):600-7. DMCLA2D RU https://pubmed.ncbi.nlm.nih.gov/21421710 DMCLA2D DI DMCLA2D DMCLA2D DN triazine compound PC10 DMCLA2D MI TTB9CIL DMCLA2D MN Prokineticin receptor-1 (PROKR1) DMCLA2D MT DTT DMCLA2D MA Antagonist DMCLA2D RN Prokineticin receptor 1 antagonist PC-10 as a biomarker for imaging inflammatory pain. J Nucl Med. 2011 Apr;52(4):600-7. DMCLA2D RU https://pubmed.ncbi.nlm.nih.gov/21421710 DM1F2K0 DI DM1F2K0 DM1F2K0 DN Triazolopyridine DM1F2K0 MI TTQBR95 DM1F2K0 MN Stress-activated protein kinase 2a (p38 alpha) DM1F2K0 MT DTT DM1F2K0 MA Inhibitor DM1F2K0 RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DM1F2K0 RU https://pubmed.ncbi.nlm.nih.gov/10592235 DM5ZBF3 DI DM5ZBF3 DM5ZBF3 DN TRIAZOLOPYRIMIDINE DM5ZBF3 MI TT7HF4W DM5ZBF3 MN Cyclin-dependent kinase 2 (CDK2) DM5ZBF3 MT DTT DM5ZBF3 MA Inhibitor DM5ZBF3 RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DM5ZBF3 RU https://pubmed.ncbi.nlm.nih.gov/10592235 DMYSX0K DI DMYSX0K DMYSX0K DN Tribenzyl 2-aminopropane-1,2,3-tricarboxylate DMYSX0K MI TTHI19T DMYSX0K MN Staphylococcus Beta-lactamase (Stap-coc blaZ) DMYSX0K MT DTT DMYSX0K MA Inhibitor DMYSX0K RN Discovery of novel lipophilic inhibitors of OXA-10 enzyme (class D beta-lactamase) by screening amino analogs and homologs of citrate and isocitrate. Bioorg Med Chem Lett. 2009 Jul 1;19(13):3593-7. DMYSX0K RU https://pubmed.ncbi.nlm.nih.gov/19467869 DMHN7CB DI DMHN7CB DMHN7CB DN Tributylstannanyl DMHN7CB MI TT6PEUO DMHN7CB MN Retinoic acid receptor RXR-alpha (RXRA) DMHN7CB MT DTT DMHN7CB MA Inhibitor DMHN7CB RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DMHN7CB RU https://pubmed.ncbi.nlm.nih.gov/10592235 DMLKWTG DI DMLKWTG DMLKWTG DN Tricarballylic Acid DMLKWTG MI TTMTF2P DMLKWTG MN Citrate hydro-lyase (ACO2) DMLKWTG MT DTT DMLKWTG MA Inhibitor DMLKWTG RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMLKWTG RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMNALMF DI DMNALMF DMNALMF DN trichloroethanol DMNALMF MI TTPC4TU DMNALMF MN 5-HT 3A receptor (HTR3A) DMNALMF MT DTT DMNALMF MA Modulator (allosteric modulator) DMNALMF RN Arginine 246 of the pretransmembrane domain 1 region alters 2,2,2-trichloroethanol action in the 5-hydroxytryptamine3A receptor. J Pharmacol Exp Ther. 2008 Mar;324(3):1011-8. DMNALMF RU https://pubmed.ncbi.nlm.nih.gov/18094321 DMNALMF DI DMNALMF DMNALMF DN trichloroethanol DMNALMF MI TTR6K75 DMNALMF MN 5-HT 3B receptor (HTR3B) DMNALMF MT DTT DMNALMF MA Modulator (allosteric modulator) DMNALMF RN Co-expression of the 5-HT(3B) subunit with the 5-HT(3A) receptor reduces alcohol sensitivity. Brain Res Mol Brain Res. 2005 Dec 14;142(2):146-50. DMNALMF RU https://pubmed.ncbi.nlm.nih.gov/16257471 DM9C8NX DI DM9C8NX DM9C8NX DN Trichostatin A DM9C8NX MI TTBH0VX DM9C8NX MN Histone deacetylase (HDAC) DM9C8NX MT DTT DM9C8NX MA Inhibitor DM9C8NX RN Histone deacetylase inhibitors induce apoptosis, histone hyperacetylation and up-regulation of gene transcription in Schistosoma mansoni. Mol Biochem Parasitol. 2009 Nov;168(1):7-15. DM9C8NX RU https://pubmed.ncbi.nlm.nih.gov/19538992 DMYB57J DI DMYB57J DMYB57J DN Triclosan monophosphate DMYB57J MI DEA9TJ6 DMYB57J MN Alkaline phosphatase (ALP) DMYB57J MT DME DMYB57J MA Metabolism DMYB57J RN Hydrolysis of triclosan monophosphate by dental plaque and selected species of oral micro-organisms. J Dent Res. 1996 Aug;75(8):1578-84. DMYB57J RU https://pubmed.ncbi.nlm.nih.gov/8906126 DM5Q7K8 DI DM5Q7K8 DM5Q7K8 DN Triethyl 2-aminopropane-1,2,3-tricarboxylate DM5Q7K8 MI TTHI19T DM5Q7K8 MN Staphylococcus Beta-lactamase (Stap-coc blaZ) DM5Q7K8 MT DTT DM5Q7K8 MA Inhibitor DM5Q7K8 RN Discovery of novel lipophilic inhibitors of OXA-10 enzyme (class D beta-lactamase) by screening amino analogs and homologs of citrate and isocitrate. Bioorg Med Chem Lett. 2009 Jul 1;19(13):3593-7. DM5Q7K8 RU https://pubmed.ncbi.nlm.nih.gov/19467869 DMUPK6G DI DMUPK6G DMUPK6G DN Triethylcholine DMUPK6G MI DTWI9TE DMUPK6G MN High affinity choline transporter 1 (SLC5A7) DMUPK6G MT DTP DMUPK6G MA Substrate DMUPK6G RN The IUPHAR/BPS Guide to PHARMACOLOGY in 2018: updates and expansion to encompass the new guide to IMMUNOPHARMACOLOGY. Nucleic Acids Res. 2018 Jan 4;46(D1):D1091-D1106. (familyId=172) DMUPK6G RU http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=172 DMAWTUL DI DMAWTUL DMAWTUL DN Trifluoroethanol DMAWTUL MI TTJS7O4 DMAWTUL MN Entamoeba Alcohol dehydrogenase 2 (Entamo ADH2) DMAWTUL MT DTT DMAWTUL MA Inhibitor DMAWTUL RN DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Nucleic Acids Res. 2011 Jan;39(Database issue):D1035-41. DMAWTUL RU https://pubmed.ncbi.nlm.nih.gov/21059682 DM4IKBV DI DM4IKBV DM4IKBV DN Trifluoromethionine DM4IKBV MI TT1UY5C DM4IKBV MN Pseudomonas Methionine gamma-lyase (Pseudo mdeA) DM4IKBV MT DTT DM4IKBV MA Inhibitor DM4IKBV RN Kinetic characterization of methionine gamma-lyases from the enteric protozoan parasite Entamoeba histolytica against physiological substrates and trifluoromethionine, a promising lead compound against amoebiasis. FEBS J. 2008 Feb;275(3):548-60. DM4IKBV RU https://pubmed.ncbi.nlm.nih.gov/18199285 DMEPFAB DI DMEPFAB DMEPFAB DN Trifluoromethylketone DMEPFAB MI TTBH0VX DMEPFAB MN Histone deacetylase (HDAC) DMEPFAB MT DTT DMEPFAB MA Inhibitor DMEPFAB RN Anticancer activities of histone deacetylase inhibitors. Nat Rev Drug Discov. 2006 Sep;5(9):769-84. DMEPFAB RU https://pubmed.ncbi.nlm.nih.gov/16955068 DMIZX8P DI DMIZX8P DMIZX8P DN Triflupromazine DMIZX8P MI TTAIY2U DMIZX8P MN HUMAN clathrin-mediated endocytosis (RME) DMIZX8P MT DTT DMIZX8P MA Inhibitor DMIZX8P RN Repurposing of clinically developed drugs for treatment of Middle East respiratory syndrome coronavirus infection. Antimicrob Agents Chemother. 2014 Aug;58(8):4885-93. DMIZX8P RU https://pubmed.ncbi.nlm.nih.gov/24841273 DMSP56N DI DMSP56N DMSP56N DN trihydroxycholestane DMSP56N MI TT7LCTF DMSP56N MN Pregnane X receptor (NR1I2) DMSP56N MT DTT DMSP56N MA Agonist DMSP56N RN Identification of bile acid precursors as endogenous ligands for the nuclear xenobiotic pregnane X receptor. Proc Natl Acad Sci U S A. 2003 Jan 7;100(1):223-8. DMSP56N RU https://pubmed.ncbi.nlm.nih.gov/12509506 DMVJD1A DI DMVJD1A DMVJD1A DN Triiodo-l-thyronine DMVJD1A MI DEYWLRK DMVJD1A MN Sulfotransferase 1A1 (SULT1A1) DMVJD1A MT DME DMVJD1A MA Metabolism DMVJD1A RN Characterization of human liver thermostable phenol sulfotransferase (SULT1A1) allozymes with 3,3',5-triiodothyronine as the substrate. J Endocrinol. 2001 Dec;171(3):525-32. DMVJD1A RU https://www.ncbi.nlm.nih.gov/pubmed/?term=11739018 DMNHU4M DI DMNHU4M DMNHU4M DN TRIM DMNHU4M MI TTBECWA DMNHU4M MN Transient receptor potential cation channel V2 (TRPV2) DMNHU4M MT DTT DMNHU4M MA Blocker (channel blocker) DMNHU4M RN Pharmacological characterization and molecular determinants of the activation of transient receptor potential V2 channel orthologs by 2-aminoethoxy... Mol Pharmacol. 2007 Nov;72(5):1258-68. DMNHU4M RU https://pubmed.ncbi.nlm.nih.gov/17673572 DMPXHTY DI DMPXHTY DMPXHTY DN TRIMEDOXIME DMPXHTY MI TT1RS9F DMPXHTY MN Acetylcholinesterase (AChE) DMPXHTY MT DTT DMPXHTY MA Inhibitor DMPXHTY RN Synthesis of the novel series of bispyridinium compounds bearing (E)-but-2-ene linker and evaluation of their reactivation activity against chlorpy... Bioorg Med Chem Lett. 2006 Feb;16(3):622-7. DMPXHTY RU https://pubmed.ncbi.nlm.nih.gov/16288867 DMQXPMB DI DMQXPMB DMQXPMB DN Trimethyl-(3-nitro-phenyl)-ammonium iodide DMQXPMB MI TT1RS9F DMQXPMB MN Acetylcholinesterase (AChE) DMQXPMB MT DTT DMQXPMB MA Inhibitor DMQXPMB RN Structure-based alignment and comparative molecular field analysis of acetylcholinesterase inhibitors. J Med Chem. 1996 Dec 20;39(26):5064-71. DMQXPMB RU https://pubmed.ncbi.nlm.nih.gov/8978837 DMJ4I98 DI DMJ4I98 DMJ4I98 DN Trimethyl-(4-oxo-pentyl)-ammonium iodide DMJ4I98 MI TT1RS9F DMJ4I98 MN Acetylcholinesterase (AChE) DMJ4I98 MT DTT DMJ4I98 MA Inhibitor DMJ4I98 RN Structure-based alignment and comparative molecular field analysis of acetylcholinesterase inhibitors. J Med Chem. 1996 Dec 20;39(26):5064-71. DMJ4I98 RU https://pubmed.ncbi.nlm.nih.gov/8978837 DM8LJ3C DI DM8LJ3C DM8LJ3C DN trimethylamine DM8LJ3C MI TTCO25G DM8LJ3C MN Trace amine receptor 5 (TAAR5) DM8LJ3C MT DTT DM8LJ3C MA Agonist DM8LJ3C RN A second class of chemosensory receptors in the olfactory epithelium. Nature. 2006 Aug 10;442(7103):645-50. DM8LJ3C RU https://pubmed.ncbi.nlm.nih.gov/16878137 DMK9743 DI DMK9743 DMK9743 DN Trimetoquinol DMK9743 MI TTMXGCW DMK9743 MN Adrenergic receptor beta-3 (ADRB3) DMK9743 MT DTT DMK9743 MA Agonist DMK9743 RN Synthesis and human beta-adrenoceptor activity of 1-(3,5-diiodo-4- methoxybenzyl)-1,2,3,4-tetrahydroisoquinolin-6-ol derivatives in vitro. J Med Chem. 2000 Feb 24;43(4):591-8. DMK9743 RU https://pubmed.ncbi.nlm.nih.gov/10691685 DML3OYH DI DML3OYH DML3OYH DN TriMixDC DML3OYH MI TTNCIE0 DML3OYH MN CD70 antigen (CD27-L) DML3OYH MT DTT DML3OYH RN Characterization of CD8+ T-cell responses in the peripheral blood and skin injection sites of melanoma patients treated with mRNA electroporated autologous dendritic cells (TriMixDC-MEL). Biomed Res Int. 2013;2013:976383. DML3OYH RU https://pubmed.ncbi.nlm.nih.gov/23509826 DML3OYH DI DML3OYH DML3OYH DN TriMixDC DML3OYH MI TTIJP3Q DML3OYH MN TNF related activation protein (CD40LG) DML3OYH MT DTT DML3OYH RN Characterization of CD8+ T-cell responses in the peripheral blood and skin injection sites of melanoma patients treated with mRNA electroporated autologous dendritic cells (TriMixDC-MEL). Biomed Res Int. 2013;2013:976383. DML3OYH RU https://pubmed.ncbi.nlm.nih.gov/23509826 DML3OYH DI DML3OYH DML3OYH DN TriMixDC DML3OYH MI TTISGCA DML3OYH MN Toll-like receptor 4 (TLR4) DML3OYH MT DTT DML3OYH RN Characterization of CD8+ T-cell responses in the peripheral blood and skin injection sites of melanoma patients treated with mRNA electroporated autologous dendritic cells (TriMixDC-MEL). Biomed Res Int. 2013;2013:976383. DML3OYH RU https://pubmed.ncbi.nlm.nih.gov/23509826 DM2VIDK DI DM2VIDK DM2VIDK DN Triphenylacetic acid methyl ester DM2VIDK MI TTMNI76 DM2VIDK MN Calcium-activated potassium channel (KCN) DM2VIDK MT DTT DM2VIDK MA Inhibitor DM2VIDK RN Novel inhibitors of the Gardos channel for the treatment of sickle cell disease. J Med Chem. 2008 Feb 28;51(4):976-82. DM2VIDK RU https://pubmed.ncbi.nlm.nih.gov/18232633 DM3CQIZ DI DM3CQIZ DM3CQIZ DN Triphenylmethanamine DM3CQIZ MI TTMNI76 DM3CQIZ MN Calcium-activated potassium channel (KCN) DM3CQIZ MT DTT DM3CQIZ MA Inhibitor DM3CQIZ RN Novel inhibitors of the Gardos channel for the treatment of sickle cell disease. J Med Chem. 2008 Feb 28;51(4):976-82. DM3CQIZ RU https://pubmed.ncbi.nlm.nih.gov/18232633 DMF8QR6 DI DMF8QR6 DMF8QR6 DN TRIPHLOROETHOL A DMF8QR6 MI TT8JRS7 DMF8QR6 MN Beta-secretase (BACE) DMF8QR6 MT DTT DMF8QR6 MA Inhibitor DMF8QR6 RN Molecular docking studies of phlorotannins from Eisenia bicyclis with BACE1 inhibitory activity. Bioorg Med Chem Lett. 2010 Jun 1;20(11):3211-5. DMF8QR6 RU https://pubmed.ncbi.nlm.nih.gov/20462757 DMWZ5FB DI DMWZ5FB DMWZ5FB DN tripitramine DMWZ5FB MI TTOXS3C DMWZ5FB MN Muscarinic acetylcholine receptor (CHRM) DMWZ5FB MT DTT DMWZ5FB MA Antagonist DMWZ5FB RN Binding profile of the selective muscarinic receptor antagonist tripitramine. Eur J Pharmacol. 1994 Aug 16;268(3):459-62. DMWZ5FB RU https://pubmed.ncbi.nlm.nih.gov/7805774 DMWZ5FB DI DMWZ5FB DMWZ5FB DN tripitramine DMWZ5FB MI TTQ13Z5 DMWZ5FB MN Muscarinic acetylcholine receptor M3 (CHRM3) DMWZ5FB MT DTT DMWZ5FB MA Antagonist DMWZ5FB RN Design, synthesis, and biological evaluation of pirenzepine analogs bearing a 1,2-cyclohexanediamine and perhydroquinoxaline units in exchange for the piperazine ring as antimuscarinics. Bioorg Med Chem. 2008 Aug 1;16(15):7311-20. DMWZ5FB RU https://pubmed.ncbi.nlm.nih.gov/18595721 DMBYV3M DI DMBYV3M DMBYV3M DN TRIPTOCALLINE A DMBYV3M MI TTFBNVI DMBYV3M MN Aldose reductase (AKR1B1) DMBYV3M MT DTT DMBYV3M MA Inhibitor DMBYV3M RN Structures of new friedelane-type triterpenes and eudesmane-type sesquiterpene and aldose reductase inhibitors from Salacia chinensis. J Nat Prod. 2003 Sep;66(9):1191-6. DMBYV3M RU https://pubmed.ncbi.nlm.nih.gov/14510595 DM6USPC DI DM6USPC DM6USPC DN TRISMETHOXYRESVERATROL DM6USPC MI TTI84H7 DM6USPC MN Cytochrome P450 1B1 (CYP1B1) DM6USPC MT DTT DM6USPC MA Inhibitor DM6USPC RN Design, synthesis, and discovery of novel trans-stilbene analogues as potent and selective human cytochrome P450 1B1 inhibitors. J Med Chem. 2002 Jan 3;45(1):160-4. DM6USPC RU https://pubmed.ncbi.nlm.nih.gov/11754588 DM6USPC DI DM6USPC DM6USPC DN TRISMETHOXYRESVERATROL DM6USPC MI TT3OT40 DM6USPC MN Multidrug resistance protein 1 (ABCB1) DM6USPC MT DTT DM6USPC MA Inhibitor DM6USPC RN Identification of a terphenyl derivative that blocks the cell cycle in the G0-G1 phase and induces differentiation in leukemia cells. J Med Chem. 2006 May 18;49(10):3012-8. DM6USPC RU https://pubmed.ncbi.nlm.nih.gov/16686543 DM6USPC DI DM6USPC DM6USPC DN TRISMETHOXYRESVERATROL DM6USPC MI TT3PJMV DM6USPC MN Tyrosine-protein kinase ABL1 (ABL) DM6USPC MT DTT DM6USPC MA Inhibitor DM6USPC RN Identification of a terphenyl derivative that blocks the cell cycle in the G0-G1 phase and induces differentiation in leukemia cells. J Med Chem. 2006 May 18;49(10):3012-8. DM6USPC RU https://pubmed.ncbi.nlm.nih.gov/16686543 DMQVH3J DI DMQVH3J DMQVH3J DN Trisnorsqualene alcohol DMQVH3J MI TTE14XG DMQVH3J MN Squalene monooxygenase (SQLE) DMQVH3J MT DTT DMQVH3J MA Inhibitor DMQVH3J RN Ellagitannins and hexahydroxydiphenoyl esters as inhibitors of vertebrate squalene epoxidase. J Nat Prod. 2001 Aug;64(8):1010-4. DMQVH3J RU https://pubmed.ncbi.nlm.nih.gov/11520216 DM0G2IR DI DM0G2IR DM0G2IR DN Trisnorsqualene cyclopropylamine DM0G2IR MI TTE14XG DM0G2IR MN Squalene monooxygenase (SQLE) DM0G2IR MT DTT DM0G2IR MA Inhibitor DM0G2IR RN Ellagitannins and hexahydroxydiphenoyl esters as inhibitors of vertebrate squalene epoxidase. J Nat Prod. 2001 Aug;64(8):1010-4. DM0G2IR RU https://pubmed.ncbi.nlm.nih.gov/11520216 DMQA7ZS DI DMQA7ZS DMQA7ZS DN Trisnorsqualene difluoromethylidene DMQA7ZS MI TTE14XG DMQA7ZS MN Squalene monooxygenase (SQLE) DMQA7ZS MT DTT DMQA7ZS MA Inhibitor DMQA7ZS RN Ellagitannins and hexahydroxydiphenoyl esters as inhibitors of vertebrate squalene epoxidase. J Nat Prod. 2001 Aug;64(8):1010-4. DMQA7ZS RU https://pubmed.ncbi.nlm.nih.gov/11520216 DMPVI3A DI DMPVI3A DMPVI3A DN Trisodium phosphate DMPVI3A MI TTZHA0O DMPVI3A MN Carbonic anhydrase IV (CA-IV) DMPVI3A MT DTT DMPVI3A MA Inhibitor DMPVI3A RN Carbonic anhydrase inhibitors. Interaction of isozymes I, II, IV, V, and IX with phosphates, carbamoyl phosphate, and the phosphonate antiviral dru... Bioorg Med Chem Lett. 2004 Dec 6;14(23):5763-7. DMPVI3A RU https://pubmed.ncbi.nlm.nih.gov/15501037 DMBZI5F DI DMBZI5F DMBZI5F DN TrkB NAM DMBZI5F MI TTKN7QR DMBZI5F MN BDNF/NT-3 growth factors receptor (TrkB) DMBZI5F MT DTT DMBZI5F MA Modulator DMBZI5F RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1818). DMBZI5F RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1818 DMU3E1M DI DMU3E1M DMU3E1M DN TRL-382 DMU3E1M MI TT8NGED DMU3E1M MN Prostaglandin G/H synthase 1 (COX-1) DMU3E1M MT DTT DMU3E1M MA Inhibitor DMU3E1M RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1375). DMU3E1M RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1375 DMXNSTF DI DMXNSTF DMXNSTF DN TRN-101 DMXNSTF MI TTZN7RP DMXNSTF MN Rho-associated protein kinase 1 (ROCK1) DMXNSTF MT DTT DMXNSTF MA Inhibitor DMXNSTF RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1503). DMXNSTF RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1503 DMXNSTF DI DMXNSTF DMXNSTF DN TRN-101 DMXNSTF MI TTGWKQJ DMXNSTF MN Rho-associated protein kinase 2 (ROCK2) DMXNSTF MT DTT DMXNSTF MA Inhibitor DMXNSTF RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1504). DMXNSTF RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1504 DMOMXP7 DI DMOMXP7 DMOMXP7 DN TROPOLONE DMOMXP7 MI TTULVH8 DMOMXP7 MN Tyrosinase (TYR) DMOMXP7 MT DTT DMOMXP7 MA Inhibitor DMOMXP7 RN Discovery of 4-functionalized phenyl-O-beta-D-glycosides as a new class of mushroom tyrosinase inhibitors. Bioorg Med Chem Lett. 2009 Nov 1;19(21):6157-60. DMOMXP7 RU https://pubmed.ncbi.nlm.nih.gov/19800229 DMIF6NS DI DMIF6NS DMIF6NS DN TROX-1 DMIF6NS MI TT4FDG6 DMIF6NS MN Voltage-gated calcium channel alpha Cav2.2 (CACNA1B) DMIF6NS MT DTT DMIF6NS MA Inhibitor (gating inhibitor) DMIF6NS RN Analgesic effects of a substituted N-triazole oxindole (TROX-1), a state-dependent, voltage-gated calcium channel 2 blocker. J Pharmacol Exp Ther. 2010 Aug;334(2):545-55. DMIF6NS RU https://pubmed.ncbi.nlm.nih.gov/20439438 DM48QTG DI DM48QTG DM48QTG DN Trp-Ile-Ile-Asp-Leu-Hisc(Cys-Ser-Val-Tyr-Phe-Cys) DM48QTG MI TTKRD0G DM48QTG MN Endothelin A receptor (EDNRA) DM48QTG MT DTT DM48QTG MA Inhibitor DM48QTG RN Structure-activity relationships in a series of monocyclic endothelin analogues, Bioorg. Med. Chem. Lett. 4(4):567-572 (1994). DM48QTG RU http://www.sciencedirect.com/science/article/pii/S0960894X01801566 DM48QTG DI DM48QTG DM48QTG DN Trp-Ile-Ile-Asp-Leu-Hisc(Cys-Ser-Val-Tyr-Phe-Cys) DM48QTG MI TT3ZTGU DM48QTG MN Endothelin B receptor (EDNRB) DM48QTG MT DTT DM48QTG MA Inhibitor DM48QTG RN Structure-activity relationships in a series of monocyclic endothelin analogues, Bioorg. Med. Chem. Lett. 4(4):567-572 (1994). DM48QTG RU http://www.sciencedirect.com/science/article/pii/S0960894X01801566 DMOZX8M DI DMOZX8M DMOZX8M DN Trp-Ile-Ile-Asp-Leu-Hisc(Cys-Val-Tyr-Phe-Cys) DMOZX8M MI TTKRD0G DMOZX8M MN Endothelin A receptor (EDNRA) DMOZX8M MT DTT DMOZX8M MA Inhibitor DMOZX8M RN Structure-activity relationships in a series of monocyclic endothelin analogues, Bioorg. Med. Chem. Lett. 4(4):567-572 (1994). DMOZX8M RU http://www.sciencedirect.com/science/article/pii/S0960894X01801566 DMOZX8M DI DMOZX8M DMOZX8M DN Trp-Ile-Ile-Asp-Leu-Hisc(Cys-Val-Tyr-Phe-Cys) DMOZX8M MI TT3ZTGU DMOZX8M MN Endothelin B receptor (EDNRB) DMOZX8M MT DTT DMOZX8M MA Inhibitor DMOZX8M RN Structure-activity relationships in a series of monocyclic endothelin analogues, Bioorg. Med. Chem. Lett. 4(4):567-572 (1994). DMOZX8M RU http://www.sciencedirect.com/science/article/pii/S0960894X01801566 DMDUGQ1 DI DMDUGQ1 DMDUGQ1 DN Trypanothione DMDUGQ1 MI TTRTKPV DMDUGQ1 MN Trypanosoma Trypanothione reductase (Trypano TPR) DMDUGQ1 MT DTT DMDUGQ1 MA Inhibitor DMDUGQ1 RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMDUGQ1 RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMTRYCI DI DMTRYCI DMTRYCI DN tryptanthrin DMTRYCI MI TTZJYKH DMTRYCI MN Indoleamine 2,3-dioxygenase 1 (IDO1) DMTRYCI MT DTT DMTRYCI MA Inhibitor DMTRYCI RN Discovery of tryptanthrin derivatives as potent inhibitors of indoleamine 2,3-dioxygenase with therapeutic activity in Lewis lung cancer (LLC) tumor-bearing mice. J Med Chem. 2013 Nov 14;56(21):8321-31. DMTRYCI RU https://pubmed.ncbi.nlm.nih.gov/24099220 DMV19K7 DI DMV19K7 DMV19K7 DN TRYPTOLINE DMV19K7 MI TTJQOD7 DMV19K7 MN 5-HT 2A receptor (HTR2A) DMV19K7 MT DTT DMV19K7 MA Inhibitor DMV19K7 RN Binding of beta-carbolines at 5-HT(2) serotonin receptors. Bioorg Med Chem Lett. 2003 Dec 15;13(24):4421-5. DMV19K7 RU https://pubmed.ncbi.nlm.nih.gov/14643338 DMV19K7 DI DMV19K7 DMV19K7 DN TRYPTOLINE DMV19K7 MI TTWG9A4 DMV19K7 MN Adrenergic receptor alpha-2A (ADRA2A) DMV19K7 MT DTT DMV19K7 MA Inhibitor DMV19K7 RN Binding of an imidazopyridoindole at imidazoline I2 receptors. Bioorg Med Chem Lett. 2004 Jan 19;14(2):527-9. DMV19K7 RU https://pubmed.ncbi.nlm.nih.gov/14698196 DMV19K7 DI DMV19K7 DMV19K7 DN TRYPTOLINE DMV19K7 MI TTWM4TY DMV19K7 MN Adrenergic receptor alpha-2B (ADRA2B) DMV19K7 MT DTT DMV19K7 MA Inhibitor DMV19K7 RN Binding of an imidazopyridoindole at imidazoline I2 receptors. Bioorg Med Chem Lett. 2004 Jan 19;14(2):527-9. DMV19K7 RU https://pubmed.ncbi.nlm.nih.gov/14698196 DMV19K7 DI DMV19K7 DMV19K7 DN TRYPTOLINE DMV19K7 MI TT2NUT5 DMV19K7 MN Adrenergic receptor alpha-2C (ADRA2C) DMV19K7 MT DTT DMV19K7 MA Inhibitor DMV19K7 RN Binding of an imidazopyridoindole at imidazoline I2 receptors. Bioorg Med Chem Lett. 2004 Jan 19;14(2):527-9. DMV19K7 RU https://pubmed.ncbi.nlm.nih.gov/14698196 DMV19K7 DI DMV19K7 DMV19K7 DN TRYPTOLINE DMV19K7 MI TT3WG5C DMV19K7 MN Monoamine oxidase type A (MAO-A) DMV19K7 MT DTT DMV19K7 MA Inhibitor DMV19K7 RN Binding of an imidazopyridoindole at imidazoline I2 receptors. Bioorg Med Chem Lett. 2004 Jan 19;14(2):527-9. DMV19K7 RU https://pubmed.ncbi.nlm.nih.gov/14698196 DMV19K7 DI DMV19K7 DMV19K7 DN TRYPTOLINE DMV19K7 MI TTGP7BY DMV19K7 MN Monoamine oxidase type B (MAO-B) DMV19K7 MT DTT DMV19K7 MA Inhibitor DMV19K7 RN Binding of an imidazopyridoindole at imidazoline I2 receptors. Bioorg Med Chem Lett. 2004 Jan 19;14(2):527-9. DMV19K7 RU https://pubmed.ncbi.nlm.nih.gov/14698196 DMIV75Q DI DMIV75Q DMIV75Q DN TS antisense + raltitrexed DMIV75Q MI TTP1UKZ DMIV75Q MN Thymidylate synthase messenger RNA (TYMS mRNA) DMIV75Q MT DTT DMIV75Q RN Design and development of antisense drugs. Expert Opin. Drug Discov. 2008 3(10):1189-1207. DMIV75Q RU http://www.informahealthcare.com/doi/abs/10.1517/17460441.3.10.1177 DM6JF7T DI DM6JF7T DM6JF7T DN TSERaM DM6JF7T MI TTZAYWL DM6JF7T MN Estrogen receptor (ESR) DM6JF7T MT DTT DM6JF7T MA Modulator DM6JF7T RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 620). DM6JF7T RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=620 DM6NZFH DI DM6NZFH DM6NZFH DN TTH 03-001 DM6NZFH MI TTNVEIR DM6NZFH MN Prostaglandin D2 receptor (PTGDR) DM6NZFH MT DTT DM6NZFH MA Modulator DM6NZFH RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 338). DM6NZFH RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=338 DMDM7C6 DI DMDM7C6 DMDM7C6 DN TTL-1177 DMDM7C6 MI TTZPWGN DMDM7C6 MN Voltage-gated calcium channel alpha Cav3.2 (CACNA1H) DMDM7C6 MT DTT DMDM7C6 MA Inhibitor DMDM7C6 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 536). DMDM7C6 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=536 DMSABD0 DI DMSABD0 DMSABD0 DN TTNPB DMSABD0 MI TTISP28 DMSABD0 MN Retinoic acid receptor beta (RARB) DMSABD0 MT DTT DMSABD0 MA Inhibitor DMSABD0 RN 9-cis-retinoic acid analogues with bulky hydrophobic rings: new RXR-selective agonists. Bioorg Med Chem Lett. 2004 Dec 20;14(24):6117-22. DMSABD0 RU https://pubmed.ncbi.nlm.nih.gov/15546741 DMUR0TF DI DMUR0TF DMUR0TF DN Tu-514 DMUR0TF MI TT0OFWN DMUR0TF MN Pseudomonas UDP-3-O-acyl-GlcNAc deacetylase (Pseudo lpxC) DMUR0TF MT DTT DMUR0TF MA Inhibitor DMUR0TF RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMUR0TF RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMYR8SG DI DMYR8SG DMYR8SG DN Tubacin DMYR8SG MI TT5ZKDI DMYR8SG MN Histone deacetylase 6 (HDAC6) DMYR8SG MT DTT DMYR8SG MA Inhibitor DMYR8SG RN Emerging therapies for multiple myeloma. Expert Opin Emerg Drugs. 2009 Mar;14(1):99-127. DMYR8SG RU https://pubmed.ncbi.nlm.nih.gov/19249983 DMHICK8 DI DMHICK8 DMHICK8 DN Tubercidin DMHICK8 MI DTZAWTH DMHICK8 MN Equilibrative nucleoside transporter 3 (SLC29A3) DMHICK8 MT DTP DMHICK8 MA Substrate DMHICK8 RN Functional characterization of novel human and mouse equilibrative nucleoside transporters (hENT3 and mENT3) located in intracellular membranes. J Biol Chem. 2005 Apr 22;280(16):15880-7. DMHICK8 RU http://www.ncbi.nlm.nih.gov/pubmed/15701636 DM2H0PQ DI DM2H0PQ DM2H0PQ DN TUG-424 DM2H0PQ MI TTB8FUC DM2H0PQ MN Free fatty acid receptor 1 (GPR40) DM2H0PQ MT DTT DM2H0PQ MA Agonist DM2H0PQ RN Discovery of potent and selective agonists for the free fatty acid receptor 1 (FFA(1)/GPR40), a potential target for the treatment of type II diabetes. J Med Chem. 2008 Nov 27;51(22):7061-4. DM2H0PQ RU https://pubmed.ncbi.nlm.nih.gov/18947221 DM8YN42 DI DM8YN42 DM8YN42 DN TUG-469 DM8YN42 MI TTB8FUC DM8YN42 MN Free fatty acid receptor 1 (GPR40) DM8YN42 MT DTT DM8YN42 MA Agonist DM8YN42 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 225). DM8YN42 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=225 DM487HF DI DM487HF DM487HF DN TUG-770 DM487HF MI TTB8FUC DM487HF MN Free fatty acid receptor 1 (GPR40) DM487HF MT DTT DM487HF MA Agonist DM487HF RN Discovery of TUG-770: A Highly Potent Free Fatty Acid Receptor 1 (FFA1/GPR40) Agonist for Treatment of Type 2 Diabetes. ACS Med Chem Lett. 2013 May 9;4(5):441-445. DM487HF RU https://pubmed.ncbi.nlm.nih.gov/23687558 DMJRGZT DI DMJRGZT DMJRGZT DN TUG-891 DMJRGZT MI TT08JVB DMJRGZT MN G-protein coupled receptor 120 (GPR120) DMJRGZT MT DTT DMJRGZT MA Agonist DMJRGZT RN Discovery of a potent and selective GPR120 agonist. J Med Chem. 2012 May 10;55(9):4511-5. DMJRGZT RU https://pubmed.ncbi.nlm.nih.gov/22519963 DMIRQ65 DI DMIRQ65 DMIRQ65 DN Tumor vascular thrombogen DMIRQ65 MI TT6L509 DMIRQ65 MN Coagulation factor IIa (F2) DMIRQ65 MT DTT DMIRQ65 MA Modulator DMIRQ65 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2362). DMIRQ65 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2362 DMAUTRP DI DMAUTRP DMAUTRP DN TUPICHINOL C DMAUTRP MI TTOM3J0 DMAUTRP MN Estrogen receptor beta (ESR2) DMAUTRP MT DTT DMAUTRP MA Inhibitor DMAUTRP RN New estrogenic compounds isolated from Broussonetia kazinoki. Bioorg Med Chem Lett. 2010 Jun 15;20(12):3764-7. DMAUTRP RU https://pubmed.ncbi.nlm.nih.gov/20493686 DMLDYVB DI DMLDYVB DMLDYVB DN TURBINATINE DMLDYVB MI TT1RS9F DMLDYVB MN Acetylcholinesterase (AChE) DMLDYVB MT DTT DMLDYVB MA Inhibitor DMLDYVB RN Indole glucoalkaloids from Chimarrhis turbinata and their evaluation as antioxidant agents and acetylcholinesterase inhibitors. J Nat Prod. 2004 Nov;67(11):1882-5. DMLDYVB RU https://pubmed.ncbi.nlm.nih.gov/15568781 DM3QE8P DI DM3QE8P DM3QE8P DN Turmeric extracts DM3QE8P MI TTE4KHA DM3QE8P MN Amyloid beta A4 protein (APP) DM3QE8P MT DTT DM3QE8P MA Inhibitor DM3QE8P RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2402). DM3QE8P RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2402 DMDE8YS DI DMDE8YS DMDE8YS DN TW-37 DMDE8YS MI TTJGNVC DMDE8YS MN Apoptosis regulator Bcl-2 (BCL-2) DMDE8YS MT DTT DMDE8YS MA Inhibitor DMDE8YS RN Structure-based design of potent small-molecule inhibitors of anti-apoptotic Bcl-2 proteins. J Med Chem. 2006 Oct 19;49(21):6139-42. DMDE8YS RU https://pubmed.ncbi.nlm.nih.gov/17034116 DMDE8YS DI DMDE8YS DMDE8YS DN TW-37 DMDE8YS MI TTRE6AX DMDE8YS MN Bcl-x messenger RNA (BCL2L1 mRNA) DMDE8YS MT DTT DMDE8YS MA Inhibitor DMDE8YS RN Fragment-based deconstruction of Bcl-xL inhibitors. J Med Chem. 2010 Mar 25;53(6):2577-88. DMDE8YS RU https://pubmed.ncbi.nlm.nih.gov/20192224 DMDE8YS DI DMDE8YS DMDE8YS DN TW-37 DMDE8YS MI TTL53M6 DMDE8YS MN Induced myeloid leukemia cell differentiation protein Mcl-1 (MCL1) DMDE8YS MT DTT DMDE8YS MA Inhibitor DMDE8YS RN Structure-based design of potent small-molecule inhibitors of anti-apoptotic Bcl-2 proteins. J Med Chem. 2006 Oct 19;49(21):6139-42. DMDE8YS RU https://pubmed.ncbi.nlm.nih.gov/17034116 DMS29M4 DI DMS29M4 DMS29M4 DN TWS-119 DMS29M4 MI TTRSMW9 DMS29M4 MN Glycogen synthase kinase-3 beta (GSK-3B) DMS29M4 MT DTT DMS29M4 MA Inhibitor DMS29M4 RN Diversity-oriented synthesis: exploring the intersections between chemistry and biology. Nat Chem Biol. 2005 Jul;1(2):74-84. DMS29M4 RU https://pubmed.ncbi.nlm.nih.gov/16408003 DMS29M4 DI DMS29M4 DMS29M4 DN TWS-119 DMS29M4 MI TTZILNJ DMS29M4 MN Proto-oncogene c-Myc (MYC) DMS29M4 MT DTT DMS29M4 MA Inhibitor DMS29M4 RN Diversity-oriented synthesis: exploring the intersections between chemistry and biology. Nat Chem Biol. 2005 Jul;1(2):74-84. DMS29M4 RU https://pubmed.ncbi.nlm.nih.gov/16408003 DMS29M4 DI DMS29M4 DMS29M4 DN TWS-119 DMS29M4 MI TTN3GBV DMS29M4 MN Transcription factor AP-1 (JUN) DMS29M4 MT DTT DMS29M4 MA Inhibitor DMS29M4 RN Diversity-oriented synthesis: exploring the intersections between chemistry and biology. Nat Chem Biol. 2005 Jul;1(2):74-84. DMS29M4 RU https://pubmed.ncbi.nlm.nih.gov/16408003 DMHFCZA DI DMHFCZA DMHFCZA DN Tylophorinidine DMHFCZA MI TT9SL3Q DMHFCZA MN Polypeptide deformylase (PDF) DMHFCZA MT DTT DMHFCZA MA Inhibitor DMHFCZA RN Inhibition of dihydrofolate reductase and cell growth activity by the phenanthroindolizidine alkaloids pergularinine and tylophorinidine: the in vitro cytotoxicity of these plant alkaloids and their potential as antimicrobial and anticancer agents. Toxicol In Vitro. 2000 Feb;14(1):53-9. DMHFCZA RU https://pubmed.ncbi.nlm.nih.gov/10699361 DMIWPKB DI DMIWPKB DMIWPKB DN Tyr-(NMe)Ala-L-Phe-D-Pro-NH2 DMIWPKB MI TT27RFC DMIWPKB MN Opioid receptor delta (OPRD1) DMIWPKB MT DTT DMIWPKB MA Inhibitor DMIWPKB RN A topochemical approach to explain morphiceptin bioactivity. J Med Chem. 1993 Mar 19;36(6):708-19. DMIWPKB RU https://pubmed.ncbi.nlm.nih.gov/8384662 DMIWPKB DI DMIWPKB DMIWPKB DN Tyr-(NMe)Ala-L-Phe-D-Pro-NH2 DMIWPKB MI TTKWM86 DMIWPKB MN Opioid receptor mu (MOP) DMIWPKB MT DTT DMIWPKB MA Inhibitor DMIWPKB RN A topochemical approach to explain morphiceptin bioactivity. J Med Chem. 1993 Mar 19;36(6):708-19. DMIWPKB RU https://pubmed.ncbi.nlm.nih.gov/8384662 DMDQJUO DI DMDQJUO DMDQJUO DN Tyr-(R)-Aba-Gly-Phe-NH2 DMDQJUO MI TT27RFC DMDQJUO MN Opioid receptor delta (OPRD1) DMDQJUO MT DTT DMDQJUO MA Inhibitor DMDQJUO RN Endomorphin-2 with a beta-turn backbone constraint retains the potent micro-opioid receptor agonist properties. J Med Chem. 2008 Jan 10;51(1):173-7. DMDQJUO RU https://pubmed.ncbi.nlm.nih.gov/18062664 DMDQJUO DI DMDQJUO DMDQJUO DN Tyr-(R)-Aba-Gly-Phe-NH2 DMDQJUO MI TTKWM86 DMDQJUO MN Opioid receptor mu (MOP) DMDQJUO MT DTT DMDQJUO MA Inhibitor DMDQJUO RN Endomorphin-2 with a beta-turn backbone constraint retains the potent micro-opioid receptor agonist properties. J Med Chem. 2008 Jan 10;51(1):173-7. DMDQJUO RU https://pubmed.ncbi.nlm.nih.gov/18062664 DMHNM3K DI DMHNM3K DMHNM3K DN Tyr-(R)-spiro-Aba-Gly-Phe-NH2 DMHNM3K MI TTKWM86 DMHNM3K MN Opioid receptor mu (MOP) DMHNM3K MT DTT DMHNM3K MA Inhibitor DMHNM3K RN Endomorphin-2 with a beta-turn backbone constraint retains the potent micro-opioid receptor agonist properties. J Med Chem. 2008 Jan 10;51(1):173-7. DMHNM3K RU https://pubmed.ncbi.nlm.nih.gov/18062664 DMYZ792 DI DMYZ792 DMYZ792 DN Tyr-(S)-Aba-Gly-Phe-NH2 DMYZ792 MI TT27RFC DMYZ792 MN Opioid receptor delta (OPRD1) DMYZ792 MT DTT DMYZ792 MA Inhibitor DMYZ792 RN Endomorphin-2 with a beta-turn backbone constraint retains the potent micro-opioid receptor agonist properties. J Med Chem. 2008 Jan 10;51(1):173-7. DMYZ792 RU https://pubmed.ncbi.nlm.nih.gov/18062664 DMYZ792 DI DMYZ792 DMYZ792 DN Tyr-(S)-Aba-Gly-Phe-NH2 DMYZ792 MI TTKWM86 DMYZ792 MN Opioid receptor mu (MOP) DMYZ792 MT DTT DMYZ792 MA Inhibitor DMYZ792 RN Endomorphin-2 with a beta-turn backbone constraint retains the potent micro-opioid receptor agonist properties. J Med Chem. 2008 Jan 10;51(1):173-7. DMYZ792 RU https://pubmed.ncbi.nlm.nih.gov/18062664 DMT316S DI DMT316S DMT316S DN Tyr-(S)-spiro-Aba-Gly-Phe-NH2 DMT316S MI TT27RFC DMT316S MN Opioid receptor delta (OPRD1) DMT316S MT DTT DMT316S MA Inhibitor DMT316S RN Endomorphin-2 with a beta-turn backbone constraint retains the potent micro-opioid receptor agonist properties. J Med Chem. 2008 Jan 10;51(1):173-7. DMT316S RU https://pubmed.ncbi.nlm.nih.gov/18062664 DMT316S DI DMT316S DMT316S DN Tyr-(S)-spiro-Aba-Gly-Phe-NH2 DMT316S MI TTKWM86 DMT316S MN Opioid receptor mu (MOP) DMT316S MT DTT DMT316S MA Inhibitor DMT316S RN Endomorphin-2 with a beta-turn backbone constraint retains the potent micro-opioid receptor agonist properties. J Med Chem. 2008 Jan 10;51(1):173-7. DMT316S RU https://pubmed.ncbi.nlm.nih.gov/18062664 DM4UXT1 DI DM4UXT1 DM4UXT1 DN Tyramine DM4UXT1 MI DE6SOC5 DM4UXT1 MN Copper amine oxidase (AOC3) DM4UXT1 MT DME DM4UXT1 MA Metabolism DM4UXT1 RN The unique substrate specificity of human AOC2, a semicarbazide-sensitive amine oxidase. Cell Mol Life Sci. 2009 Aug;66(16):2743-57. DM4UXT1 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=19588076 DM4UXT1 DI DM4UXT1 DM4UXT1 DN Tyramine DM4UXT1 MI DTT79CX DM4UXT1 MN Organic cation transporter 1 (SLC22A1) DM4UXT1 MT DTP DM4UXT1 MA Substrate DM4UXT1 RN Human intestinal transporter database: QSAR modeling and virtual profiling of drug uptake, efflux and interactions. Pharm Res. 2013 Apr;30(4):996-1007. DM4UXT1 RU https://doi.org/10.1007/s11095-012-0935-x DM4UXT1 DI DM4UXT1 DM4UXT1 DN Tyramine DM4UXT1 MI DE8DP90 DM4UXT1 MN Semicarbazide-sensitive amine oxidase (AOC2) DM4UXT1 MT DME DM4UXT1 MA Metabolism DM4UXT1 RN The unique substrate specificity of human AOC2, a semicarbazide-sensitive amine oxidase. Cell Mol Life Sci. 2009 Aug;66(16):2743-57. DM4UXT1 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=19588076 DM4UXT1 DI DM4UXT1 DM4UXT1 DN Tyramine DM4UXT1 MI TTIU98M DM4UXT1 MN Trace amine-associated receptor-1 (TAAR1) DM4UXT1 MT DTT DM4UXT1 MA Agonist DM4UXT1 RN Differential modulation of Beta-adrenergic receptor signaling by trace amine-associated receptor 1 agonists. PLoS One. 2011;6(10):e27073. DM4UXT1 RU https://pubmed.ncbi.nlm.nih.gov/22073124 DM0D1Z5 DI DM0D1Z5 DM0D1Z5 DN Tyr-D-Ala-Gly-D-Trp-Nle-Asp-Phe-NH2 DM0D1Z5 MI TTCG0AL DM0D1Z5 MN Cholecystokinin receptor type A (CCKAR) DM0D1Z5 MT DTT DM0D1Z5 MA Inhibitor DM0D1Z5 RN Structure-activity relationships of bifunctional peptides based on overlapping pharmacophores at opioid and cholecystokinin receptors. J Med Chem. 2006 May 18;49(10):2868-75. DM0D1Z5 RU https://pubmed.ncbi.nlm.nih.gov/16686530 DM0D1Z5 DI DM0D1Z5 DM0D1Z5 DN Tyr-D-Ala-Gly-D-Trp-Nle-Asp-Phe-NH2 DM0D1Z5 MI TTVFO0U DM0D1Z5 MN Gastrin/cholecystokinin type B receptor (CCKBR) DM0D1Z5 MT DTT DM0D1Z5 MA Inhibitor DM0D1Z5 RN Structure-activity relationships of bifunctional peptides based on overlapping pharmacophores at opioid and cholecystokinin receptors. J Med Chem. 2006 May 18;49(10):2868-75. DM0D1Z5 RU https://pubmed.ncbi.nlm.nih.gov/16686530 DM0D1Z5 DI DM0D1Z5 DM0D1Z5 DN Tyr-D-Ala-Gly-D-Trp-Nle-Asp-Phe-NH2 DM0D1Z5 MI TT27RFC DM0D1Z5 MN Opioid receptor delta (OPRD1) DM0D1Z5 MT DTT DM0D1Z5 MA Inhibitor DM0D1Z5 RN Structure-activity relationships of bifunctional peptides based on overlapping pharmacophores at opioid and cholecystokinin receptors. J Med Chem. 2006 May 18;49(10):2868-75. DM0D1Z5 RU https://pubmed.ncbi.nlm.nih.gov/16686530 DM0D1Z5 DI DM0D1Z5 DM0D1Z5 DN Tyr-D-Ala-Gly-D-Trp-Nle-Asp-Phe-NH2 DM0D1Z5 MI TTKWM86 DM0D1Z5 MN Opioid receptor mu (MOP) DM0D1Z5 MT DTT DM0D1Z5 MA Inhibitor DM0D1Z5 RN Structure-activity relationships of bifunctional peptides based on overlapping pharmacophores at opioid and cholecystokinin receptors. J Med Chem. 2006 May 18;49(10):2868-75. DM0D1Z5 RU https://pubmed.ncbi.nlm.nih.gov/16686530 DMPH1G0 DI DMPH1G0 DMPH1G0 DN Tyr-D-Ala-Gly-D-Trp-NMeNle-Asp-Phe-NH2 DMPH1G0 MI TTCG0AL DMPH1G0 MN Cholecystokinin receptor type A (CCKAR) DMPH1G0 MT DTT DMPH1G0 MA Inhibitor DMPH1G0 RN Structure-activity relationships of bifunctional peptides based on overlapping pharmacophores at opioid and cholecystokinin receptors. J Med Chem. 2006 May 18;49(10):2868-75. DMPH1G0 RU https://pubmed.ncbi.nlm.nih.gov/16686530 DMPH1G0 DI DMPH1G0 DMPH1G0 DN Tyr-D-Ala-Gly-D-Trp-NMeNle-Asp-Phe-NH2 DMPH1G0 MI TTVFO0U DMPH1G0 MN Gastrin/cholecystokinin type B receptor (CCKBR) DMPH1G0 MT DTT DMPH1G0 MA Inhibitor DMPH1G0 RN Structure-activity relationships of bifunctional peptides based on overlapping pharmacophores at opioid and cholecystokinin receptors. J Med Chem. 2006 May 18;49(10):2868-75. DMPH1G0 RU https://pubmed.ncbi.nlm.nih.gov/16686530 DMPH1G0 DI DMPH1G0 DMPH1G0 DN Tyr-D-Ala-Gly-D-Trp-NMeNle-Asp-Phe-NH2 DMPH1G0 MI TT27RFC DMPH1G0 MN Opioid receptor delta (OPRD1) DMPH1G0 MT DTT DMPH1G0 MA Inhibitor DMPH1G0 RN Structure-activity relationships of bifunctional peptides based on overlapping pharmacophores at opioid and cholecystokinin receptors. J Med Chem. 2006 May 18;49(10):2868-75. DMPH1G0 RU https://pubmed.ncbi.nlm.nih.gov/16686530 DMPH1G0 DI DMPH1G0 DMPH1G0 DN Tyr-D-Ala-Gly-D-Trp-NMeNle-Asp-Phe-NH2 DMPH1G0 MI TTKWM86 DMPH1G0 MN Opioid receptor mu (MOP) DMPH1G0 MT DTT DMPH1G0 MA Inhibitor DMPH1G0 RN Structure-activity relationships of bifunctional peptides based on overlapping pharmacophores at opioid and cholecystokinin receptors. J Med Chem. 2006 May 18;49(10):2868-75. DMPH1G0 RU https://pubmed.ncbi.nlm.nih.gov/16686530 DM2XRZL DI DM2XRZL DM2XRZL DN Tyr-D-Ala-Gly-NMePhe DM2XRZL MI TTKWM86 DM2XRZL MN Opioid receptor mu (MOP) DM2XRZL MT DTT DM2XRZL MA Inhibitor DM2XRZL RN Discovery of dermorphin-based affinity labels with subnanomolar affinity for mu opioid receptors. J Med Chem. 2009 Dec 10;52(23):7372-5. DM2XRZL RU https://pubmed.ncbi.nlm.nih.gov/19621878 DMC7LND DI DMC7LND DMC7LND DN Tyr-D-Ala-Gly-Phe-Met-NH2 DMC7LND MI TT27RFC DMC7LND MN Opioid receptor delta (OPRD1) DMC7LND MT DTT DMC7LND MA Inhibitor DMC7LND RN The biological activity and metabolic stability of peptidic bifunctional compounds that are opioid receptor agonists and neurokinin-1 receptor anta... Bioorg Med Chem. 2009 Oct 15;17(20):7337-43. DMC7LND RU https://pubmed.ncbi.nlm.nih.gov/19762245 DMC7LND DI DMC7LND DMC7LND DN Tyr-D-Ala-Gly-Phe-Met-NH2 DMC7LND MI TTKWM86 DMC7LND MN Opioid receptor mu (MOP) DMC7LND MT DTT DMC7LND MA Inhibitor DMC7LND RN Biological and conformational evaluation of bifunctional compounds for opioid receptor agonists and neurokinin 1 receptor antagonists possessing tw... J Med Chem. 2010 Aug 12;53(15):5491-501. DMC7LND RU https://pubmed.ncbi.nlm.nih.gov/20617791 DMWOP9N DI DMWOP9N DMWOP9N DN Tyr-D-Ala-Gly-Phe-Met-Pro-Leu-Trp-NH-Bzl DMWOP9N MI TT27RFC DMWOP9N MN Opioid receptor delta (OPRD1) DMWOP9N MT DTT DMWOP9N MA Inhibitor DMWOP9N RN The importance of micelle-bound states for the bioactivities of bifunctional peptide derivatives for delta/mu opioid receptor agonists and neurokin... J Med Chem. 2008 Oct 23;51(20):6334-47. DMWOP9N RU https://pubmed.ncbi.nlm.nih.gov/18821747 DMWOP9N DI DMWOP9N DMWOP9N DN Tyr-D-Ala-Gly-Phe-Met-Pro-Leu-Trp-NH-Bzl DMWOP9N MI TTKWM86 DMWOP9N MN Opioid receptor mu (MOP) DMWOP9N MT DTT DMWOP9N MA Inhibitor DMWOP9N RN The importance of micelle-bound states for the bioactivities of bifunctional peptide derivatives for delta/mu opioid receptor agonists and neurokin... J Med Chem. 2008 Oct 23;51(20):6334-47. DMWOP9N RU https://pubmed.ncbi.nlm.nih.gov/18821747 DMWOP9N DI DMWOP9N DMWOP9N DN Tyr-D-Ala-Gly-Phe-Met-Pro-Leu-Trp-NH-Bzl DMWOP9N MI TTZPO1L DMWOP9N MN Substance-P receptor (TACR1) DMWOP9N MT DTT DMWOP9N MA Inhibitor DMWOP9N RN The importance of micelle-bound states for the bioactivities of bifunctional peptide derivatives for delta/mu opioid receptor agonists and neurokin... J Med Chem. 2008 Oct 23;51(20):6334-47. DMWOP9N RU https://pubmed.ncbi.nlm.nih.gov/18821747 DMB2TCF DI DMB2TCF DMB2TCF DN Tyr-D-Ala-Gly-Phe-NH-NH-Phe-Asp-NMeNle-D-Trp-Boc DMB2TCF MI TTCG0AL DMB2TCF MN Cholecystokinin receptor type A (CCKAR) DMB2TCF MT DTT DMB2TCF MA Inhibitor DMB2TCF RN Design and synthesis of novel hydrazide-linked bifunctional peptides as delta/mu opioid receptor agonists and CCK-1/CCK-2 receptor antagonists. J Med Chem. 2006 Mar 9;49(5):1773-80. DMB2TCF RU https://pubmed.ncbi.nlm.nih.gov/16509592 DMB2TCF DI DMB2TCF DMB2TCF DN Tyr-D-Ala-Gly-Phe-NH-NH-Phe-Asp-NMeNle-D-Trp-Boc DMB2TCF MI TTVFO0U DMB2TCF MN Gastrin/cholecystokinin type B receptor (CCKBR) DMB2TCF MT DTT DMB2TCF MA Inhibitor DMB2TCF RN Design and synthesis of novel hydrazide-linked bifunctional peptides as delta/mu opioid receptor agonists and CCK-1/CCK-2 receptor antagonists. J Med Chem. 2006 Mar 9;49(5):1773-80. DMB2TCF RU https://pubmed.ncbi.nlm.nih.gov/16509592 DMB2TCF DI DMB2TCF DMB2TCF DN Tyr-D-Ala-Gly-Phe-NH-NH-Phe-Asp-NMeNle-D-Trp-Boc DMB2TCF MI TT27RFC DMB2TCF MN Opioid receptor delta (OPRD1) DMB2TCF MT DTT DMB2TCF MA Inhibitor DMB2TCF RN Design and synthesis of novel hydrazide-linked bifunctional peptides as delta/mu opioid receptor agonists and CCK-1/CCK-2 receptor antagonists. J Med Chem. 2006 Mar 9;49(5):1773-80. DMB2TCF RU https://pubmed.ncbi.nlm.nih.gov/16509592 DMB2TCF DI DMB2TCF DMB2TCF DN Tyr-D-Ala-Gly-Phe-NH-NH-Phe-Asp-NMeNle-D-Trp-Boc DMB2TCF MI TTKWM86 DMB2TCF MN Opioid receptor mu (MOP) DMB2TCF MT DTT DMB2TCF MA Inhibitor DMB2TCF RN Design and synthesis of novel hydrazide-linked bifunctional peptides as delta/mu opioid receptor agonists and CCK-1/CCK-2 receptor antagonists. J Med Chem. 2006 Mar 9;49(5):1773-80. DMB2TCF RU https://pubmed.ncbi.nlm.nih.gov/16509592 DMUXMVQ DI DMUXMVQ DMUXMVQ DN Tyr-D-Ala-Gly-Trp-Nle-Asp-Phe-NH2 DMUXMVQ MI TTCG0AL DMUXMVQ MN Cholecystokinin receptor type A (CCKAR) DMUXMVQ MT DTT DMUXMVQ MA Inhibitor DMUXMVQ RN Structure-activity relationships of bifunctional peptides based on overlapping pharmacophores at opioid and cholecystokinin receptors. J Med Chem. 2006 May 18;49(10):2868-75. DMUXMVQ RU https://pubmed.ncbi.nlm.nih.gov/16686530 DMUXMVQ DI DMUXMVQ DMUXMVQ DN Tyr-D-Ala-Gly-Trp-Nle-Asp-Phe-NH2 DMUXMVQ MI TTVFO0U DMUXMVQ MN Gastrin/cholecystokinin type B receptor (CCKBR) DMUXMVQ MT DTT DMUXMVQ MA Inhibitor DMUXMVQ RN Structure-activity relationships of bifunctional peptides based on overlapping pharmacophores at opioid and cholecystokinin receptors. J Med Chem. 2006 May 18;49(10):2868-75. DMUXMVQ RU https://pubmed.ncbi.nlm.nih.gov/16686530 DMUXMVQ DI DMUXMVQ DMUXMVQ DN Tyr-D-Ala-Gly-Trp-Nle-Asp-Phe-NH2 DMUXMVQ MI TT27RFC DMUXMVQ MN Opioid receptor delta (OPRD1) DMUXMVQ MT DTT DMUXMVQ MA Inhibitor DMUXMVQ RN Structure-activity relationships of bifunctional peptides based on overlapping pharmacophores at opioid and cholecystokinin receptors. J Med Chem. 2006 May 18;49(10):2868-75. DMUXMVQ RU https://pubmed.ncbi.nlm.nih.gov/16686530 DMUXMVQ DI DMUXMVQ DMUXMVQ DN Tyr-D-Ala-Gly-Trp-Nle-Asp-Phe-NH2 DMUXMVQ MI TTKWM86 DMUXMVQ MN Opioid receptor mu (MOP) DMUXMVQ MT DTT DMUXMVQ MA Inhibitor DMUXMVQ RN Structure-activity relationships of bifunctional peptides based on overlapping pharmacophores at opioid and cholecystokinin receptors. J Med Chem. 2006 May 18;49(10):2868-75. DMUXMVQ RU https://pubmed.ncbi.nlm.nih.gov/16686530 DMREJ69 DI DMREJ69 DMREJ69 DN Tyr-D-Ala-Gly-Trp-NMeNle-Asp-Phe-NH2 DMREJ69 MI TTCG0AL DMREJ69 MN Cholecystokinin receptor type A (CCKAR) DMREJ69 MT DTT DMREJ69 MA Inhibitor DMREJ69 RN Structure-activity relationships of bifunctional peptides based on overlapping pharmacophores at opioid and cholecystokinin receptors. J Med Chem. 2006 May 18;49(10):2868-75. DMREJ69 RU https://pubmed.ncbi.nlm.nih.gov/16686530 DMREJ69 DI DMREJ69 DMREJ69 DN Tyr-D-Ala-Gly-Trp-NMeNle-Asp-Phe-NH2 DMREJ69 MI TTVFO0U DMREJ69 MN Gastrin/cholecystokinin type B receptor (CCKBR) DMREJ69 MT DTT DMREJ69 MA Inhibitor DMREJ69 RN Structure-activity relationships of bifunctional peptides based on overlapping pharmacophores at opioid and cholecystokinin receptors. J Med Chem. 2006 May 18;49(10):2868-75. DMREJ69 RU https://pubmed.ncbi.nlm.nih.gov/16686530 DMREJ69 DI DMREJ69 DMREJ69 DN Tyr-D-Ala-Gly-Trp-NMeNle-Asp-Phe-NH2 DMREJ69 MI TT27RFC DMREJ69 MN Opioid receptor delta (OPRD1) DMREJ69 MT DTT DMREJ69 MA Inhibitor DMREJ69 RN Structure-activity relationships of bifunctional peptides based on overlapping pharmacophores at opioid and cholecystokinin receptors. J Med Chem. 2006 May 18;49(10):2868-75. DMREJ69 RU https://pubmed.ncbi.nlm.nih.gov/16686530 DMREJ69 DI DMREJ69 DMREJ69 DN Tyr-D-Ala-Gly-Trp-NMeNle-Asp-Phe-NH2 DMREJ69 MI TTKWM86 DMREJ69 MN Opioid receptor mu (MOP) DMREJ69 MT DTT DMREJ69 MA Inhibitor DMREJ69 RN Structure-activity relationships of bifunctional peptides based on overlapping pharmacophores at opioid and cholecystokinin receptors. J Med Chem. 2006 May 18;49(10):2868-75. DMREJ69 RU https://pubmed.ncbi.nlm.nih.gov/16686530 DMTPLNZ DI DMTPLNZ DMTPLNZ DN Tyr-D-Ala-Phe-Asp-Val-Val-Thr[Beta-D-Glc]-Gly-NH2 DMTPLNZ MI TT27RFC DMTPLNZ MN Opioid receptor delta (OPRD1) DMTPLNZ MT DTT DMTPLNZ MA Inhibitor DMTPLNZ RN Synthesis and pharmacological activity of deltorphin and dermorphin-related glycopeptides. J Med Chem. 1997 Aug 29;40(18):2948-52. DMTPLNZ RU https://pubmed.ncbi.nlm.nih.gov/9288177 DMTPLNZ DI DMTPLNZ DMTPLNZ DN Tyr-D-Ala-Phe-Asp-Val-Val-Thr[Beta-D-Glc]-Gly-NH2 DMTPLNZ MI TTKWM86 DMTPLNZ MN Opioid receptor mu (MOP) DMTPLNZ MT DTT DMTPLNZ MA Inhibitor DMTPLNZ RN Synthesis and pharmacological activity of deltorphin and dermorphin-related glycopeptides. J Med Chem. 1997 Aug 29;40(18):2948-52. DMTPLNZ RU https://pubmed.ncbi.nlm.nih.gov/9288177 DMC4NO5 DI DMC4NO5 DMC4NO5 DN Tyr-D-Ala-Phe-Glu-Val-Val-Gly-NH2 DMC4NO5 MI TT27RFC DMC4NO5 MN Opioid receptor delta (OPRD1) DMC4NO5 MT DTT DMC4NO5 MA Inhibitor DMC4NO5 RN Design of cyclic deltorphins and dermenkephalins with a disulfide bridge leads to analogues with high selectivity for delta-opioid receptors. J Med Chem. 1994 Jan 7;37(1):141-5. DMC4NO5 RU https://pubmed.ncbi.nlm.nih.gov/8289187 DMC4NO5 DI DMC4NO5 DMC4NO5 DN Tyr-D-Ala-Phe-Glu-Val-Val-Gly-NH2 DMC4NO5 MI TTKWM86 DMC4NO5 MN Opioid receptor mu (MOP) DMC4NO5 MT DTT DMC4NO5 MA Inhibitor DMC4NO5 RN Design of cyclic deltorphins and dermenkephalins with a disulfide bridge leads to analogues with high selectivity for delta-opioid receptors. J Med Chem. 1994 Jan 7;37(1):141-5. DMC4NO5 RU https://pubmed.ncbi.nlm.nih.gov/8289187 DM4FASR DI DM4FASR DM4FASR DN Tyr-D-Ala-Phe-Gly-Tyr-Pro-Thr(Beta-D-Glc)-Gly-NH2 DM4FASR MI TT27RFC DM4FASR MN Opioid receptor delta (OPRD1) DM4FASR MT DTT DM4FASR MA Inhibitor DM4FASR RN Synthesis and pharmacological activity of deltorphin and dermorphin-related glycopeptides. J Med Chem. 1997 Aug 29;40(18):2948-52. DM4FASR RU https://pubmed.ncbi.nlm.nih.gov/9288177 DM4FASR DI DM4FASR DM4FASR DN Tyr-D-Ala-Phe-Gly-Tyr-Pro-Thr(Beta-D-Glc)-Gly-NH2 DM4FASR MI TTKWM86 DM4FASR MN Opioid receptor mu (MOP) DM4FASR MT DTT DM4FASR MA Inhibitor DM4FASR RN Synthesis and pharmacological activity of deltorphin and dermorphin-related glycopeptides. J Med Chem. 1997 Aug 29;40(18):2948-52. DM4FASR RU https://pubmed.ncbi.nlm.nih.gov/9288177 DMB9A46 DI DMB9A46 DMB9A46 DN Tyr-D-Ala-Phe-Thr(-D-Glc)-Tyr-Pro-Ser-NH2 DMB9A46 MI TT27RFC DMB9A46 MN Opioid receptor delta (OPRD1) DMB9A46 MT DTT DMB9A46 MA Inhibitor DMB9A46 RN Synthesis and pharmacological activity of deltorphin and dermorphin-related glycopeptides. J Med Chem. 1997 Aug 29;40(18):2948-52. DMB9A46 RU https://pubmed.ncbi.nlm.nih.gov/9288177 DMB9A46 DI DMB9A46 DMB9A46 DN Tyr-D-Ala-Phe-Thr(-D-Glc)-Tyr-Pro-Ser-NH2 DMB9A46 MI TTKWM86 DMB9A46 MN Opioid receptor mu (MOP) DMB9A46 MT DTT DMB9A46 MA Inhibitor DMB9A46 RN Synthesis and pharmacological activity of deltorphin and dermorphin-related glycopeptides. J Med Chem. 1997 Aug 29;40(18):2948-52. DMB9A46 RU https://pubmed.ncbi.nlm.nih.gov/9288177 DMLC0NW DI DMLC0NW DMLC0NW DN Tyr-D-Ala-Phe-Thr[-D-Glc(OAc)4]-Tyr-Pro-Ser-NH2 DMLC0NW MI TTKWM86 DMLC0NW MN Opioid receptor mu (MOP) DMLC0NW MT DTT DMLC0NW MA Inhibitor DMLC0NW RN Synthesis and pharmacological activity of deltorphin and dermorphin-related glycopeptides. J Med Chem. 1997 Aug 29;40(18):2948-52. DMLC0NW RU https://pubmed.ncbi.nlm.nih.gov/9288177 DM4YTFP DI DM4YTFP DM4YTFP DN Tyr-D-Met-Phe-His-Leu-Met-Asp-NH2 DM4YTFP MI TT27RFC DM4YTFP MN Opioid receptor delta (OPRD1) DM4YTFP MT DTT DM4YTFP MA Inhibitor DM4YTFP RN Design of cyclic deltorphins and dermenkephalins with a disulfide bridge leads to analogues with high selectivity for delta-opioid receptors. J Med Chem. 1994 Jan 7;37(1):141-5. DM4YTFP RU https://pubmed.ncbi.nlm.nih.gov/8289187 DM4YTFP DI DM4YTFP DM4YTFP DN Tyr-D-Met-Phe-His-Leu-Met-Asp-NH2 DM4YTFP MI TTKWM86 DM4YTFP MN Opioid receptor mu (MOP) DM4YTFP MT DTT DM4YTFP MA Inhibitor DM4YTFP RN Design of cyclic deltorphins and dermenkephalins with a disulfide bridge leads to analogues with high selectivity for delta-opioid receptors. J Med Chem. 1994 Jan 7;37(1):141-5. DM4YTFP RU https://pubmed.ncbi.nlm.nih.gov/8289187 DMY9NIJ DI DMY9NIJ DMY9NIJ DN Tyr-D-Nle-Gly-D-Trp-Nle-Asp-Phe-NH2 DMY9NIJ MI TTVFO0U DMY9NIJ MN Gastrin/cholecystokinin type B receptor (CCKBR) DMY9NIJ MT DTT DMY9NIJ MA Inhibitor DMY9NIJ RN Structure-activity relationships of bifunctional peptides based on overlapping pharmacophores at opioid and cholecystokinin receptors. J Med Chem. 2006 May 18;49(10):2868-75. DMY9NIJ RU https://pubmed.ncbi.nlm.nih.gov/16686530 DMY9NIJ DI DMY9NIJ DMY9NIJ DN Tyr-D-Nle-Gly-D-Trp-Nle-Asp-Phe-NH2 DMY9NIJ MI TT27RFC DMY9NIJ MN Opioid receptor delta (OPRD1) DMY9NIJ MT DTT DMY9NIJ MA Inhibitor DMY9NIJ RN Structure-activity relationships of bifunctional peptides based on overlapping pharmacophores at opioid and cholecystokinin receptors. J Med Chem. 2006 May 18;49(10):2868-75. DMY9NIJ RU https://pubmed.ncbi.nlm.nih.gov/16686530 DMY9NIJ DI DMY9NIJ DMY9NIJ DN Tyr-D-Nle-Gly-D-Trp-Nle-Asp-Phe-NH2 DMY9NIJ MI TTKWM86 DMY9NIJ MN Opioid receptor mu (MOP) DMY9NIJ MT DTT DMY9NIJ MA Inhibitor DMY9NIJ RN Structure-activity relationships of bifunctional peptides based on overlapping pharmacophores at opioid and cholecystokinin receptors. J Med Chem. 2006 May 18;49(10):2868-75. DMY9NIJ RU https://pubmed.ncbi.nlm.nih.gov/16686530 DMQREP2 DI DMQREP2 DMQREP2 DN Tyr-D-Nle-Gly-D-Trp-NMeNle-Asp-Phe-NH2 DMQREP2 MI TTCG0AL DMQREP2 MN Cholecystokinin receptor type A (CCKAR) DMQREP2 MT DTT DMQREP2 MA Inhibitor DMQREP2 RN Structure-activity relationships of bifunctional peptides based on overlapping pharmacophores at opioid and cholecystokinin receptors. J Med Chem. 2006 May 18;49(10):2868-75. DMQREP2 RU https://pubmed.ncbi.nlm.nih.gov/16686530 DMQREP2 DI DMQREP2 DMQREP2 DN Tyr-D-Nle-Gly-D-Trp-NMeNle-Asp-Phe-NH2 DMQREP2 MI TTVFO0U DMQREP2 MN Gastrin/cholecystokinin type B receptor (CCKBR) DMQREP2 MT DTT DMQREP2 MA Inhibitor DMQREP2 RN Structure-activity relationships of bifunctional peptides based on overlapping pharmacophores at opioid and cholecystokinin receptors. J Med Chem. 2006 May 18;49(10):2868-75. DMQREP2 RU https://pubmed.ncbi.nlm.nih.gov/16686530 DMQREP2 DI DMQREP2 DMQREP2 DN Tyr-D-Nle-Gly-D-Trp-NMeNle-Asp-Phe-NH2 DMQREP2 MI TT27RFC DMQREP2 MN Opioid receptor delta (OPRD1) DMQREP2 MT DTT DMQREP2 MA Inhibitor DMQREP2 RN Structure-activity relationships of bifunctional peptides based on overlapping pharmacophores at opioid and cholecystokinin receptors. J Med Chem. 2006 May 18;49(10):2868-75. DMQREP2 RU https://pubmed.ncbi.nlm.nih.gov/16686530 DMQREP2 DI DMQREP2 DMQREP2 DN Tyr-D-Nle-Gly-D-Trp-NMeNle-Asp-Phe-NH2 DMQREP2 MI TTKWM86 DMQREP2 MN Opioid receptor mu (MOP) DMQREP2 MT DTT DMQREP2 MA Inhibitor DMQREP2 RN Structure-activity relationships of bifunctional peptides based on overlapping pharmacophores at opioid and cholecystokinin receptors. J Med Chem. 2006 May 18;49(10):2868-75. DMQREP2 RU https://pubmed.ncbi.nlm.nih.gov/16686530 DMZ24LN DI DMZ24LN DMZ24LN DN Tyr-D-Nle-Gly-Trp-Nle-Asp-Phe-NH2 DMZ24LN MI TTCG0AL DMZ24LN MN Cholecystokinin receptor type A (CCKAR) DMZ24LN MT DTT DMZ24LN MA Inhibitor DMZ24LN RN Structure-activity relationships of bifunctional peptides based on overlapping pharmacophores at opioid and cholecystokinin receptors. J Med Chem. 2006 May 18;49(10):2868-75. DMZ24LN RU https://pubmed.ncbi.nlm.nih.gov/16686530 DMZ24LN DI DMZ24LN DMZ24LN DN Tyr-D-Nle-Gly-Trp-Nle-Asp-Phe-NH2 DMZ24LN MI TTVFO0U DMZ24LN MN Gastrin/cholecystokinin type B receptor (CCKBR) DMZ24LN MT DTT DMZ24LN MA Inhibitor DMZ24LN RN Structure-activity relationships of bifunctional peptides based on overlapping pharmacophores at opioid and cholecystokinin receptors. J Med Chem. 2006 May 18;49(10):2868-75. DMZ24LN RU https://pubmed.ncbi.nlm.nih.gov/16686530 DMZ24LN DI DMZ24LN DMZ24LN DN Tyr-D-Nle-Gly-Trp-Nle-Asp-Phe-NH2 DMZ24LN MI TT27RFC DMZ24LN MN Opioid receptor delta (OPRD1) DMZ24LN MT DTT DMZ24LN MA Inhibitor DMZ24LN RN Structure-activity relationships of bifunctional peptides based on overlapping pharmacophores at opioid and cholecystokinin receptors. J Med Chem. 2006 May 18;49(10):2868-75. DMZ24LN RU https://pubmed.ncbi.nlm.nih.gov/16686530 DMZ24LN DI DMZ24LN DMZ24LN DN Tyr-D-Nle-Gly-Trp-Nle-Asp-Phe-NH2 DMZ24LN MI TTKWM86 DMZ24LN MN Opioid receptor mu (MOP) DMZ24LN MT DTT DMZ24LN MA Inhibitor DMZ24LN RN Structure-activity relationships of bifunctional peptides based on overlapping pharmacophores at opioid and cholecystokinin receptors. J Med Chem. 2006 May 18;49(10):2868-75. DMZ24LN RU https://pubmed.ncbi.nlm.nih.gov/16686530 DMPSJ72 DI DMPSJ72 DMPSJ72 DN Tyr-D-Nle-Gly-Trp-NMeNle-Asp-Phe-NH2 DMPSJ72 MI TTVFO0U DMPSJ72 MN Gastrin/cholecystokinin type B receptor (CCKBR) DMPSJ72 MT DTT DMPSJ72 MA Inhibitor DMPSJ72 RN Structure-activity relationships of bifunctional peptides based on overlapping pharmacophores at opioid and cholecystokinin receptors. J Med Chem. 2006 May 18;49(10):2868-75. DMPSJ72 RU https://pubmed.ncbi.nlm.nih.gov/16686530 DMPSJ72 DI DMPSJ72 DMPSJ72 DN Tyr-D-Nle-Gly-Trp-NMeNle-Asp-Phe-NH2 DMPSJ72 MI TT27RFC DMPSJ72 MN Opioid receptor delta (OPRD1) DMPSJ72 MT DTT DMPSJ72 MA Inhibitor DMPSJ72 RN Structure-activity relationships of bifunctional peptides based on overlapping pharmacophores at opioid and cholecystokinin receptors. J Med Chem. 2006 May 18;49(10):2868-75. DMPSJ72 RU https://pubmed.ncbi.nlm.nih.gov/16686530 DMPSJ72 DI DMPSJ72 DMPSJ72 DN Tyr-D-Nle-Gly-Trp-NMeNle-Asp-Phe-NH2 DMPSJ72 MI TTKWM86 DMPSJ72 MN Opioid receptor mu (MOP) DMPSJ72 MT DTT DMPSJ72 MA Inhibitor DMPSJ72 RN Structure-activity relationships of bifunctional peptides based on overlapping pharmacophores at opioid and cholecystokinin receptors. J Med Chem. 2006 May 18;49(10):2868-75. DMPSJ72 RU https://pubmed.ncbi.nlm.nih.gov/16686530 DMIWMN6 DI DMIWMN6 DMIWMN6 DN Tyr-D-Phe-Gly-D-Trp-Nle-Asp-Phe-NH2 DMIWMN6 MI TTCG0AL DMIWMN6 MN Cholecystokinin receptor type A (CCKAR) DMIWMN6 MT DTT DMIWMN6 MA Inhibitor DMIWMN6 RN Structure-activity relationships of bifunctional peptides based on overlapping pharmacophores at opioid and cholecystokinin receptors. J Med Chem. 2006 May 18;49(10):2868-75. DMIWMN6 RU https://pubmed.ncbi.nlm.nih.gov/16686530 DMIWMN6 DI DMIWMN6 DMIWMN6 DN Tyr-D-Phe-Gly-D-Trp-Nle-Asp-Phe-NH2 DMIWMN6 MI TTVFO0U DMIWMN6 MN Gastrin/cholecystokinin type B receptor (CCKBR) DMIWMN6 MT DTT DMIWMN6 MA Inhibitor DMIWMN6 RN Structure-activity relationships of bifunctional peptides based on overlapping pharmacophores at opioid and cholecystokinin receptors. J Med Chem. 2006 May 18;49(10):2868-75. DMIWMN6 RU https://pubmed.ncbi.nlm.nih.gov/16686530 DMIWMN6 DI DMIWMN6 DMIWMN6 DN Tyr-D-Phe-Gly-D-Trp-Nle-Asp-Phe-NH2 DMIWMN6 MI TT27RFC DMIWMN6 MN Opioid receptor delta (OPRD1) DMIWMN6 MT DTT DMIWMN6 MA Inhibitor DMIWMN6 RN Structure-activity relationships of bifunctional peptides based on overlapping pharmacophores at opioid and cholecystokinin receptors. J Med Chem. 2006 May 18;49(10):2868-75. DMIWMN6 RU https://pubmed.ncbi.nlm.nih.gov/16686530 DMIWMN6 DI DMIWMN6 DMIWMN6 DN Tyr-D-Phe-Gly-D-Trp-Nle-Asp-Phe-NH2 DMIWMN6 MI TTKWM86 DMIWMN6 MN Opioid receptor mu (MOP) DMIWMN6 MT DTT DMIWMN6 MA Inhibitor DMIWMN6 RN Structure-activity relationships of bifunctional peptides based on overlapping pharmacophores at opioid and cholecystokinin receptors. J Med Chem. 2006 May 18;49(10):2868-75. DMIWMN6 RU https://pubmed.ncbi.nlm.nih.gov/16686530 DM2CEWT DI DM2CEWT DM2CEWT DN Tyr-D-Phe-Gly-D-Trp-NMeNle-Asp-Phe-NH2 DM2CEWT MI TTCG0AL DM2CEWT MN Cholecystokinin receptor type A (CCKAR) DM2CEWT MT DTT DM2CEWT MA Inhibitor DM2CEWT RN Structure-activity relationships of bifunctional peptides based on overlapping pharmacophores at opioid and cholecystokinin receptors. J Med Chem. 2006 May 18;49(10):2868-75. DM2CEWT RU https://pubmed.ncbi.nlm.nih.gov/16686530 DM2CEWT DI DM2CEWT DM2CEWT DN Tyr-D-Phe-Gly-D-Trp-NMeNle-Asp-Phe-NH2 DM2CEWT MI TTVFO0U DM2CEWT MN Gastrin/cholecystokinin type B receptor (CCKBR) DM2CEWT MT DTT DM2CEWT MA Inhibitor DM2CEWT RN Structure-activity relationships of bifunctional peptides based on overlapping pharmacophores at opioid and cholecystokinin receptors. J Med Chem. 2006 May 18;49(10):2868-75. DM2CEWT RU https://pubmed.ncbi.nlm.nih.gov/16686530 DM2CEWT DI DM2CEWT DM2CEWT DN Tyr-D-Phe-Gly-D-Trp-NMeNle-Asp-Phe-NH2 DM2CEWT MI TT27RFC DM2CEWT MN Opioid receptor delta (OPRD1) DM2CEWT MT DTT DM2CEWT MA Inhibitor DM2CEWT RN Structure-activity relationships of bifunctional peptides based on overlapping pharmacophores at opioid and cholecystokinin receptors. J Med Chem. 2006 May 18;49(10):2868-75. DM2CEWT RU https://pubmed.ncbi.nlm.nih.gov/16686530 DM2CEWT DI DM2CEWT DM2CEWT DN Tyr-D-Phe-Gly-D-Trp-NMeNle-Asp-Phe-NH2 DM2CEWT MI TTKWM86 DM2CEWT MN Opioid receptor mu (MOP) DM2CEWT MT DTT DM2CEWT MA Inhibitor DM2CEWT RN Structure-activity relationships of bifunctional peptides based on overlapping pharmacophores at opioid and cholecystokinin receptors. J Med Chem. 2006 May 18;49(10):2868-75. DM2CEWT RU https://pubmed.ncbi.nlm.nih.gov/16686530 DMKM81A DI DMKM81A DMKM81A DN Tyr-D-Phe-Gly-Trp-Nle-Asp-Phe-NH2 DMKM81A MI TTCG0AL DMKM81A MN Cholecystokinin receptor type A (CCKAR) DMKM81A MT DTT DMKM81A MA Inhibitor DMKM81A RN Structure-activity relationships of bifunctional peptides based on overlapping pharmacophores at opioid and cholecystokinin receptors. J Med Chem. 2006 May 18;49(10):2868-75. DMKM81A RU https://pubmed.ncbi.nlm.nih.gov/16686530 DMKM81A DI DMKM81A DMKM81A DN Tyr-D-Phe-Gly-Trp-Nle-Asp-Phe-NH2 DMKM81A MI TTVFO0U DMKM81A MN Gastrin/cholecystokinin type B receptor (CCKBR) DMKM81A MT DTT DMKM81A MA Inhibitor DMKM81A RN Structure-activity relationships of bifunctional peptides based on overlapping pharmacophores at opioid and cholecystokinin receptors. J Med Chem. 2006 May 18;49(10):2868-75. DMKM81A RU https://pubmed.ncbi.nlm.nih.gov/16686530 DMKM81A DI DMKM81A DMKM81A DN Tyr-D-Phe-Gly-Trp-Nle-Asp-Phe-NH2 DMKM81A MI TT27RFC DMKM81A MN Opioid receptor delta (OPRD1) DMKM81A MT DTT DMKM81A MA Inhibitor DMKM81A RN Structure-activity relationships of bifunctional peptides based on overlapping pharmacophores at opioid and cholecystokinin receptors. J Med Chem. 2006 May 18;49(10):2868-75. DMKM81A RU https://pubmed.ncbi.nlm.nih.gov/16686530 DMKM81A DI DMKM81A DMKM81A DN Tyr-D-Phe-Gly-Trp-Nle-Asp-Phe-NH2 DMKM81A MI TTKWM86 DMKM81A MN Opioid receptor mu (MOP) DMKM81A MT DTT DMKM81A MA Inhibitor DMKM81A RN Structure-activity relationships of bifunctional peptides based on overlapping pharmacophores at opioid and cholecystokinin receptors. J Med Chem. 2006 May 18;49(10):2868-75. DMKM81A RU https://pubmed.ncbi.nlm.nih.gov/16686530 DMZOTGM DI DMZOTGM DMZOTGM DN Tyr-D-Phe-Gly-Trp-NMeNle-Asp-Phe-NH2 DMZOTGM MI TTCG0AL DMZOTGM MN Cholecystokinin receptor type A (CCKAR) DMZOTGM MT DTT DMZOTGM MA Inhibitor DMZOTGM RN Structure-activity relationships of bifunctional peptides based on overlapping pharmacophores at opioid and cholecystokinin receptors. J Med Chem. 2006 May 18;49(10):2868-75. DMZOTGM RU https://pubmed.ncbi.nlm.nih.gov/16686530 DMZOTGM DI DMZOTGM DMZOTGM DN Tyr-D-Phe-Gly-Trp-NMeNle-Asp-Phe-NH2 DMZOTGM MI TTVFO0U DMZOTGM MN Gastrin/cholecystokinin type B receptor (CCKBR) DMZOTGM MT DTT DMZOTGM MA Inhibitor DMZOTGM RN Structure-activity relationships of bifunctional peptides based on overlapping pharmacophores at opioid and cholecystokinin receptors. J Med Chem. 2006 May 18;49(10):2868-75. DMZOTGM RU https://pubmed.ncbi.nlm.nih.gov/16686530 DMZOTGM DI DMZOTGM DMZOTGM DN Tyr-D-Phe-Gly-Trp-NMeNle-Asp-Phe-NH2 DMZOTGM MI TT27RFC DMZOTGM MN Opioid receptor delta (OPRD1) DMZOTGM MT DTT DMZOTGM MA Inhibitor DMZOTGM RN Structure-activity relationships of bifunctional peptides based on overlapping pharmacophores at opioid and cholecystokinin receptors. J Med Chem. 2006 May 18;49(10):2868-75. DMZOTGM RU https://pubmed.ncbi.nlm.nih.gov/16686530 DMZOTGM DI DMZOTGM DMZOTGM DN Tyr-D-Phe-Gly-Trp-NMeNle-Asp-Phe-NH2 DMZOTGM MI TTKWM86 DMZOTGM MN Opioid receptor mu (MOP) DMZOTGM MT DTT DMZOTGM MA Inhibitor DMZOTGM RN Structure-activity relationships of bifunctional peptides based on overlapping pharmacophores at opioid and cholecystokinin receptors. J Med Chem. 2006 May 18;49(10):2868-75. DMZOTGM RU https://pubmed.ncbi.nlm.nih.gov/16686530 DMM9H07 DI DMM9H07 DMM9H07 DN Tyr-D-Pro-Gly-Trp-NMeNle-Asp-Phe-NH2 DMM9H07 MI TTVFO0U DMM9H07 MN Gastrin/cholecystokinin type B receptor (CCKBR) DMM9H07 MT DTT DMM9H07 MA Inhibitor DMM9H07 RN Structure-activity relationships of bifunctional peptides based on overlapping pharmacophores at opioid and cholecystokinin receptors. J Med Chem. 2006 May 18;49(10):2868-75. DMM9H07 RU https://pubmed.ncbi.nlm.nih.gov/16686530 DMM9H07 DI DMM9H07 DMM9H07 DN Tyr-D-Pro-Gly-Trp-NMeNle-Asp-Phe-NH2 DMM9H07 MI TT27RFC DMM9H07 MN Opioid receptor delta (OPRD1) DMM9H07 MT DTT DMM9H07 MA Inhibitor DMM9H07 RN Structure-activity relationships of bifunctional peptides based on overlapping pharmacophores at opioid and cholecystokinin receptors. J Med Chem. 2006 May 18;49(10):2868-75. DMM9H07 RU https://pubmed.ncbi.nlm.nih.gov/16686530 DMM9H07 DI DMM9H07 DMM9H07 DN Tyr-D-Pro-Gly-Trp-NMeNle-Asp-Phe-NH2 DMM9H07 MI TTKWM86 DMM9H07 MN Opioid receptor mu (MOP) DMM9H07 MT DTT DMM9H07 MA Inhibitor DMM9H07 RN Structure-activity relationships of bifunctional peptides based on overlapping pharmacophores at opioid and cholecystokinin receptors. J Med Chem. 2006 May 18;49(10):2868-75. DMM9H07 RU https://pubmed.ncbi.nlm.nih.gov/16686530 DMKND2R DI DMKND2R DMKND2R DN Tyr-Gly-Gly-Phe-c(Cys-Arg-Arg-Ile-Cys)-Arg-lys DMKND2R MI TT27RFC DMKND2R MN Opioid receptor delta (OPRD1) DMKND2R MT DTT DMKND2R MA Inhibitor DMKND2R RN Design and synthesis of highly potent and selective cyclic dynorphin A analogs. 2. New analogs. J Med Chem. 1993 Mar 19;36(6):750-7. DMKND2R RU https://pubmed.ncbi.nlm.nih.gov/8096246 DMG6NDA DI DMG6NDA DMG6NDA DN Tyr-Gly-Gly-Phe-leu-c(Cys-Arg-Ile-Arg-Cys)-lys DMG6NDA MI TT27RFC DMG6NDA MN Opioid receptor delta (OPRD1) DMG6NDA MT DTT DMG6NDA MA Inhibitor DMG6NDA RN Design and synthesis of highly potent and selective cyclic dynorphin A analogs. 2. New analogs. J Med Chem. 1993 Mar 19;36(6):750-7. DMG6NDA RU https://pubmed.ncbi.nlm.nih.gov/8096246 DMN7290 DI DMN7290 DMN7290 DN Tyr-Gly-Gly-Trp-NMeNle-Asp-Phe-NH2 DMN7290 MI TTVFO0U DMN7290 MN Gastrin/cholecystokinin type B receptor (CCKBR) DMN7290 MT DTT DMN7290 MA Inhibitor DMN7290 RN Structure-activity relationships of bifunctional peptides based on overlapping pharmacophores at opioid and cholecystokinin receptors. J Med Chem. 2006 May 18;49(10):2868-75. DMN7290 RU https://pubmed.ncbi.nlm.nih.gov/16686530 DMN7290 DI DMN7290 DMN7290 DN Tyr-Gly-Gly-Trp-NMeNle-Asp-Phe-NH2 DMN7290 MI TT27RFC DMN7290 MN Opioid receptor delta (OPRD1) DMN7290 MT DTT DMN7290 MA Inhibitor DMN7290 RN Structure-activity relationships of bifunctional peptides based on overlapping pharmacophores at opioid and cholecystokinin receptors. J Med Chem. 2006 May 18;49(10):2868-75. DMN7290 RU https://pubmed.ncbi.nlm.nih.gov/16686530 DMN7290 DI DMN7290 DMN7290 DN Tyr-Gly-Gly-Trp-NMeNle-Asp-Phe-NH2 DMN7290 MI TTKWM86 DMN7290 MN Opioid receptor mu (MOP) DMN7290 MT DTT DMN7290 MA Inhibitor DMN7290 RN Structure-activity relationships of bifunctional peptides based on overlapping pharmacophores at opioid and cholecystokinin receptors. J Med Chem. 2006 May 18;49(10):2868-75. DMN7290 RU https://pubmed.ncbi.nlm.nih.gov/16686530 DM91UKB DI DM91UKB DM91UKB DN Tyropanoic acid DM91UKB MI DEP54UE DM91UKB MN Beta-glucuronidase (GUSB) DM91UKB MT DME DM91UKB MA Metabolism DM91UKB RN Foreign Compound Metabolism in Mammals. Edited by D. E. Hathway. DM91UKB RU https://books.google.ca/books?id=raKIFKRdi0AC&pg=PA423&lpg=PA423&dq=tyropanoic+acid&source=bl&ots=qASeCBztrt&sig=Ux3ZzP6AIeG9EQyKiq90uLdTUh8&hl=en&sa=X&ved=0ahUKEwjMs9PgjuDZAhUE6mMKHY3qA404ChDoAQhBMAY#v=onepage&q=tyropanoic%20acid&f=false DM87ZIH DI DM87ZIH DM87ZIH DN Tyrphostin Ag-1478 DM87ZIH MI DTI7UX6 DM87ZIH MN Breast cancer resistance protein (ABCG2) DM87ZIH MT DTP DM87ZIH MA Substrate DM87ZIH RN Inhibiting the function of ABCB1 and ABCG2 by the EGFR tyrosine kinase inhibitor AG1478. Biochem Pharmacol. 2009 Mar 1;77(5):781-93. DM87ZIH RU https://doi.org/10.1016/j.bcp.2008.11.007 DM87ZIH DI DM87ZIH DM87ZIH DN Tyrphostin Ag-1478 DM87ZIH MI TTGKNB4 DM87ZIH MN Epidermal growth factor receptor (EGFR) DM87ZIH MT DTT DM87ZIH MA Inhibitor DM87ZIH RN Use of a pharmacophore model for the design of EGFR tyrosine kinase inhibitors: isoflavones and 3-phenyl-4(1H)-quinolones. J Med Chem. 1999 Mar 25;42(6):1018-26. DM87ZIH RU https://pubmed.ncbi.nlm.nih.gov/10090785 DM87ZIH DI DM87ZIH DM87ZIH DN Tyrphostin Ag-1478 DM87ZIH MI DTUGYRD DM87ZIH MN P-glycoprotein 1 (ABCB1) DM87ZIH MT DTP DM87ZIH MA Substrate DM87ZIH RN Inhibiting the function of ABCB1 and ABCG2 by the EGFR tyrosine kinase inhibitor AG1478. Biochem Pharmacol. 2009 Mar 1;77(5):781-93. DM87ZIH RU https://doi.org/10.1016/j.bcp.2008.11.007 DM87ZIH DI DM87ZIH DM87ZIH DN Tyrphostin Ag-1478 DM87ZIH MI TTQBR95 DM87ZIH MN Stress-activated protein kinase 2a (p38 alpha) DM87ZIH MT DTT DM87ZIH MA Inhibitor DM87ZIH RN Novel, potent and selective anilinoquinazoline and anilinopyrimidine inhibitors of p38 MAP kinase. Bioorg Med Chem Lett. 2004 Nov 1;14(21):5389-94. DM87ZIH RU https://pubmed.ncbi.nlm.nih.gov/15454232 DMDCJWU DI DMDCJWU DMDCJWU DN Tyr-Pro-3,5Dmp-Phe-NH2 DMDCJWU MI TT27RFC DMDCJWU MN Opioid receptor delta (OPRD1) DMDCJWU MT DTT DMDCJWU MA Inhibitor DMDCJWU RN Bifunctional [2',6'-dimethyl-L-tyrosine1]endomorphin-2 analogues substituted at position 3 with alkylated phenylalanine derivatives yield potent mi... J Med Chem. 2007 Jun 14;50(12):2753-66. DMDCJWU RU https://pubmed.ncbi.nlm.nih.gov/17497839 DMDCJWU DI DMDCJWU DMDCJWU DN Tyr-Pro-3,5Dmp-Phe-NH2 DMDCJWU MI TTKWM86 DMDCJWU MN Opioid receptor mu (MOP) DMDCJWU MT DTT DMDCJWU MA Inhibitor DMDCJWU RN Bifunctional [2',6'-dimethyl-L-tyrosine1]endomorphin-2 analogues substituted at position 3 with alkylated phenylalanine derivatives yield potent mi... J Med Chem. 2007 Jun 14;50(12):2753-66. DMDCJWU RU https://pubmed.ncbi.nlm.nih.gov/17497839 DMH08O3 DI DMH08O3 DMH08O3 DN Tyr-Pro-D-(NMe)Phe-D-Pro-NH2 DMH08O3 MI TTKWM86 DMH08O3 MN Opioid receptor mu (MOP) DMH08O3 MT DTT DMH08O3 MA Inhibitor DMH08O3 RN A topochemical approach to explain morphiceptin bioactivity. J Med Chem. 1993 Mar 19;36(6):708-19. DMH08O3 RU https://pubmed.ncbi.nlm.nih.gov/8384662 DMNXCHT DI DMNXCHT DMNXCHT DN Tyr-Pro-Dmp-Phe-NH2 DMNXCHT MI TT27RFC DMNXCHT MN Opioid receptor delta (OPRD1) DMNXCHT MT DTT DMNXCHT MA Inhibitor DMNXCHT RN Bifunctional [2',6'-dimethyl-L-tyrosine1]endomorphin-2 analogues substituted at position 3 with alkylated phenylalanine derivatives yield potent mi... J Med Chem. 2007 Jun 14;50(12):2753-66. DMNXCHT RU https://pubmed.ncbi.nlm.nih.gov/17497839 DMNXCHT DI DMNXCHT DMNXCHT DN Tyr-Pro-Dmp-Phe-NH2 DMNXCHT MI TTKWM86 DMNXCHT MN Opioid receptor mu (MOP) DMNXCHT MT DTT DMNXCHT MA Inhibitor DMNXCHT RN Bifunctional [2',6'-dimethyl-L-tyrosine1]endomorphin-2 analogues substituted at position 3 with alkylated phenylalanine derivatives yield potent mi... J Med Chem. 2007 Jun 14;50(12):2753-66. DMNXCHT RU https://pubmed.ncbi.nlm.nih.gov/17497839 DMOU43H DI DMOU43H DMOU43H DN Tyr-Pro-Dmt-Phe-NH2 DMOU43H MI TT27RFC DMOU43H MN Opioid receptor delta (OPRD1) DMOU43H MT DTT DMOU43H MA Inhibitor DMOU43H RN Bifunctional [2',6'-dimethyl-L-tyrosine1]endomorphin-2 analogues substituted at position 3 with alkylated phenylalanine derivatives yield potent mi... J Med Chem. 2007 Jun 14;50(12):2753-66. DMOU43H RU https://pubmed.ncbi.nlm.nih.gov/17497839 DMOU43H DI DMOU43H DMOU43H DN Tyr-Pro-Dmt-Phe-NH2 DMOU43H MI TTKWM86 DMOU43H MN Opioid receptor mu (MOP) DMOU43H MT DTT DMOU43H MA Inhibitor DMOU43H RN Bifunctional [2',6'-dimethyl-L-tyrosine1]endomorphin-2 analogues substituted at position 3 with alkylated phenylalanine derivatives yield potent mi... J Med Chem. 2007 Jun 14;50(12):2753-66. DMOU43H RU https://pubmed.ncbi.nlm.nih.gov/17497839 DM4ZJR5 DI DM4ZJR5 DM4ZJR5 DN Tyr-Pro-D-Phe-D-Pro-NH2 DM4ZJR5 MI TT27RFC DM4ZJR5 MN Opioid receptor delta (OPRD1) DM4ZJR5 MT DTT DM4ZJR5 MA Inhibitor DM4ZJR5 RN A topochemical approach to explain morphiceptin bioactivity. J Med Chem. 1993 Mar 19;36(6):708-19. DM4ZJR5 RU https://pubmed.ncbi.nlm.nih.gov/8384662 DM4ZJR5 DI DM4ZJR5 DM4ZJR5 DN Tyr-Pro-D-Phe-D-Pro-NH2 DM4ZJR5 MI TTKWM86 DM4ZJR5 MN Opioid receptor mu (MOP) DM4ZJR5 MT DTT DM4ZJR5 MA Inhibitor DM4ZJR5 RN A topochemical approach to explain morphiceptin bioactivity. J Med Chem. 1993 Mar 19;36(6):708-19. DM4ZJR5 RU https://pubmed.ncbi.nlm.nih.gov/8384662 DMCTSNE DI DMCTSNE DMCTSNE DN Tyr-Pro-D-Phe-Pro-NH2 DMCTSNE MI TT27RFC DMCTSNE MN Opioid receptor delta (OPRD1) DMCTSNE MT DTT DMCTSNE MA Inhibitor DMCTSNE RN A topochemical approach to explain morphiceptin bioactivity. J Med Chem. 1993 Mar 19;36(6):708-19. DMCTSNE RU https://pubmed.ncbi.nlm.nih.gov/8384662 DMCTSNE DI DMCTSNE DMCTSNE DN Tyr-Pro-D-Phe-Pro-NH2 DMCTSNE MI TTKWM86 DMCTSNE MN Opioid receptor mu (MOP) DMCTSNE MT DTT DMCTSNE MA Inhibitor DMCTSNE RN A topochemical approach to explain morphiceptin bioactivity. J Med Chem. 1993 Mar 19;36(6):708-19. DMCTSNE RU https://pubmed.ncbi.nlm.nih.gov/8384662 DMEDVRN DI DMEDVRN DMEDVRN DN Tyr-Pro-D-Phg-Phe-NH2 DMEDVRN MI TT27RFC DMEDVRN MN Opioid receptor delta (OPRD1) DMEDVRN MT DTT DMEDVRN MA Inhibitor DMEDVRN RN Opioid receptor binding and antinociceptive activity of the analogues of endomorphin-2 and morphiceptin with phenylalanine mimics in the position 3... Bioorg Med Chem Lett. 2006 Jul 15;16(14):3688-92. DMEDVRN RU https://pubmed.ncbi.nlm.nih.gov/16682191 DMEDVRN DI DMEDVRN DMEDVRN DN Tyr-Pro-D-Phg-Phe-NH2 DMEDVRN MI TTKWM86 DMEDVRN MN Opioid receptor mu (MOP) DMEDVRN MT DTT DMEDVRN MA Inhibitor DMEDVRN RN Opioid receptor binding and antinociceptive activity of the analogues of endomorphin-2 and morphiceptin with phenylalanine mimics in the position 3... Bioorg Med Chem Lett. 2006 Jul 15;16(14):3688-92. DMEDVRN RU https://pubmed.ncbi.nlm.nih.gov/16682191 DMUKE43 DI DMUKE43 DMUKE43 DN Tyr-Pro-Emp-Phe-NH2 DMUKE43 MI TT27RFC DMUKE43 MN Opioid receptor delta (OPRD1) DMUKE43 MT DTT DMUKE43 MA Inhibitor DMUKE43 RN Bifunctional [2',6'-dimethyl-L-tyrosine1]endomorphin-2 analogues substituted at position 3 with alkylated phenylalanine derivatives yield potent mi... J Med Chem. 2007 Jun 14;50(12):2753-66. DMUKE43 RU https://pubmed.ncbi.nlm.nih.gov/17497839 DMUKE43 DI DMUKE43 DMUKE43 DN Tyr-Pro-Emp-Phe-NH2 DMUKE43 MI TTKWM86 DMUKE43 MN Opioid receptor mu (MOP) DMUKE43 MT DTT DMUKE43 MA Inhibitor DMUKE43 RN Bifunctional [2',6'-dimethyl-L-tyrosine1]endomorphin-2 analogues substituted at position 3 with alkylated phenylalanine derivatives yield potent mi... J Med Chem. 2007 Jun 14;50(12):2753-66. DMUKE43 RU https://pubmed.ncbi.nlm.nih.gov/17497839 DM8THU2 DI DM8THU2 DM8THU2 DN Tyr-Pro-Gly-Trp-NMeNle-Asp-Phe-NH2 DM8THU2 MI TTVFO0U DM8THU2 MN Gastrin/cholecystokinin type B receptor (CCKBR) DM8THU2 MT DTT DM8THU2 MA Inhibitor DM8THU2 RN Structure-activity relationships of bifunctional peptides based on overlapping pharmacophores at opioid and cholecystokinin receptors. J Med Chem. 2006 May 18;49(10):2868-75. DM8THU2 RU https://pubmed.ncbi.nlm.nih.gov/16686530 DM8THU2 DI DM8THU2 DM8THU2 DN Tyr-Pro-Gly-Trp-NMeNle-Asp-Phe-NH2 DM8THU2 MI TT27RFC DM8THU2 MN Opioid receptor delta (OPRD1) DM8THU2 MT DTT DM8THU2 MA Inhibitor DM8THU2 RN Structure-activity relationships of bifunctional peptides based on overlapping pharmacophores at opioid and cholecystokinin receptors. J Med Chem. 2006 May 18;49(10):2868-75. DM8THU2 RU https://pubmed.ncbi.nlm.nih.gov/16686530 DME5HIS DI DME5HIS DME5HIS DN Tyr-Pro-Hfe-Phe-NH2 DME5HIS MI TTKWM86 DME5HIS MN Opioid receptor mu (MOP) DME5HIS MT DTT DME5HIS MA Inhibitor DME5HIS RN Opioid receptor binding and antinociceptive activity of the analogues of endomorphin-2 and morphiceptin with phenylalanine mimics in the position 3... Bioorg Med Chem Lett. 2006 Jul 15;16(14):3688-92. DME5HIS RU https://pubmed.ncbi.nlm.nih.gov/16682191 DMJBR75 DI DMJBR75 DMJBR75 DN Tyr-Pro-Hfe-Pro-NH2 DMJBR75 MI TTKWM86 DMJBR75 MN Opioid receptor mu (MOP) DMJBR75 MT DTT DMJBR75 MA Inhibitor DMJBR75 RN Opioid receptor binding and antinociceptive activity of the analogues of endomorphin-2 and morphiceptin with phenylalanine mimics in the position 3... Bioorg Med Chem Lett. 2006 Jul 15;16(14):3688-92. DMJBR75 RU https://pubmed.ncbi.nlm.nih.gov/16682191 DMUV3ZW DI DMUV3ZW DMUV3ZW DN Tyr-Pro-Imp-Phe-NH2 DMUV3ZW MI TT27RFC DMUV3ZW MN Opioid receptor delta (OPRD1) DMUV3ZW MT DTT DMUV3ZW MA Inhibitor DMUV3ZW RN Bifunctional [2',6'-dimethyl-L-tyrosine1]endomorphin-2 analogues substituted at position 3 with alkylated phenylalanine derivatives yield potent mi... J Med Chem. 2007 Jun 14;50(12):2753-66. DMUV3ZW RU https://pubmed.ncbi.nlm.nih.gov/17497839 DMUV3ZW DI DMUV3ZW DMUV3ZW DN Tyr-Pro-Imp-Phe-NH2 DMUV3ZW MI TTKWM86 DMUV3ZW MN Opioid receptor mu (MOP) DMUV3ZW MT DTT DMUV3ZW MA Inhibitor DMUV3ZW RN Bifunctional [2',6'-dimethyl-L-tyrosine1]endomorphin-2 analogues substituted at position 3 with alkylated phenylalanine derivatives yield potent mi... J Med Chem. 2007 Jun 14;50(12):2753-66. DMUV3ZW RU https://pubmed.ncbi.nlm.nih.gov/17497839 DMI65GV DI DMI65GV DMI65GV DN Tyr-Pro-L-(NMe)Phe-D-Pro-NH2 DMI65GV MI TT27RFC DMI65GV MN Opioid receptor delta (OPRD1) DMI65GV MT DTT DMI65GV MA Inhibitor DMI65GV RN A topochemical approach to explain morphiceptin bioactivity. J Med Chem. 1993 Mar 19;36(6):708-19. DMI65GV RU https://pubmed.ncbi.nlm.nih.gov/8384662 DMI65GV DI DMI65GV DMI65GV DN Tyr-Pro-L-(NMe)Phe-D-Pro-NH2 DMI65GV MI TTKWM86 DMI65GV MN Opioid receptor mu (MOP) DMI65GV MT DTT DMI65GV MA Inhibitor DMI65GV RN A topochemical approach to explain morphiceptin bioactivity. J Med Chem. 1993 Mar 19;36(6):708-19. DMI65GV RU https://pubmed.ncbi.nlm.nih.gov/8384662 DM1NITL DI DM1NITL DM1NITL DN Tyr-Pro-L-(NMe)Phe-Pro-NH2 DM1NITL MI TT27RFC DM1NITL MN Opioid receptor delta (OPRD1) DM1NITL MT DTT DM1NITL MA Inhibitor DM1NITL RN A topochemical approach to explain morphiceptin bioactivity. J Med Chem. 1993 Mar 19;36(6):708-19. DM1NITL RU https://pubmed.ncbi.nlm.nih.gov/8384662 DM1NITL DI DM1NITL DM1NITL DN Tyr-Pro-L-(NMe)Phe-Pro-NH2 DM1NITL MI TTKWM86 DM1NITL MN Opioid receptor mu (MOP) DM1NITL MT DTT DM1NITL MA Inhibitor DM1NITL RN A topochemical approach to explain morphiceptin bioactivity. J Med Chem. 1993 Mar 19;36(6):708-19. DM1NITL RU https://pubmed.ncbi.nlm.nih.gov/8384662 DMUVHGS DI DMUVHGS DMUVHGS DN Tyr-Pro-L-Phe-D-Pro-NH2 DMUVHGS MI TT27RFC DMUVHGS MN Opioid receptor delta (OPRD1) DMUVHGS MT DTT DMUVHGS MA Inhibitor DMUVHGS RN A topochemical approach to explain morphiceptin bioactivity. J Med Chem. 1993 Mar 19;36(6):708-19. DMUVHGS RU https://pubmed.ncbi.nlm.nih.gov/8384662 DMUVHGS DI DMUVHGS DMUVHGS DN Tyr-Pro-L-Phe-D-Pro-NH2 DMUVHGS MI TTKWM86 DMUVHGS MN Opioid receptor mu (MOP) DMUVHGS MT DTT DMUVHGS MA Inhibitor DMUVHGS RN A topochemical approach to explain morphiceptin bioactivity. J Med Chem. 1993 Mar 19;36(6):708-19. DMUVHGS RU https://pubmed.ncbi.nlm.nih.gov/8384662 DM8VW3Z DI DM8VW3Z DM8VW3Z DN Tyr-Pro-L-Phe-Pro-NH2 DM8VW3Z MI TT27RFC DM8VW3Z MN Opioid receptor delta (OPRD1) DM8VW3Z MT DTT DM8VW3Z MA Inhibitor DM8VW3Z RN A topochemical approach to explain morphiceptin bioactivity. J Med Chem. 1993 Mar 19;36(6):708-19. DM8VW3Z RU https://pubmed.ncbi.nlm.nih.gov/8384662 DM8VW3Z DI DM8VW3Z DM8VW3Z DN Tyr-Pro-L-Phe-Pro-NH2 DM8VW3Z MI TTKWM86 DM8VW3Z MN Opioid receptor mu (MOP) DM8VW3Z MT DTT DM8VW3Z MA Inhibitor DM8VW3Z RN A topochemical approach to explain morphiceptin bioactivity. J Med Chem. 1993 Mar 19;36(6):708-19. DM8VW3Z RU https://pubmed.ncbi.nlm.nih.gov/8384662 DMRE7G3 DI DMRE7G3 DMRE7G3 DN Tyr-Pro-Mmp-Phe-NH DMRE7G3 MI TT27RFC DMRE7G3 MN Opioid receptor delta (OPRD1) DMRE7G3 MT DTT DMRE7G3 MA Inhibitor DMRE7G3 RN Bifunctional [2',6'-dimethyl-L-tyrosine1]endomorphin-2 analogues substituted at position 3 with alkylated phenylalanine derivatives yield potent mi... J Med Chem. 2007 Jun 14;50(12):2753-66. DMRE7G3 RU https://pubmed.ncbi.nlm.nih.gov/17497839 DMRE7G3 DI DMRE7G3 DMRE7G3 DN Tyr-Pro-Mmp-Phe-NH DMRE7G3 MI TTKWM86 DMRE7G3 MN Opioid receptor mu (MOP) DMRE7G3 MT DTT DMRE7G3 MA Inhibitor DMRE7G3 RN Bifunctional [2',6'-dimethyl-L-tyrosine1]endomorphin-2 analogues substituted at position 3 with alkylated phenylalanine derivatives yield potent mi... J Med Chem. 2007 Jun 14;50(12):2753-66. DMRE7G3 RU https://pubmed.ncbi.nlm.nih.gov/17497839 DMIE4U5 DI DMIE4U5 DMIE4U5 DN Tyr-Pro-Phe-Ala-Bn DMIE4U5 MI TTKWM86 DMIE4U5 MN Opioid receptor mu (MOP) DMIE4U5 MT DTT DMIE4U5 MA Inhibitor DMIE4U5 RN Molecular modeling studies to predict the possible binding modes of endomorphin analogs in mu opioid receptor. Bioorg Med Chem Lett. 2009 Sep 15;19(18):5387-91. DMIE4U5 RU https://pubmed.ncbi.nlm.nih.gov/19679474 DMLQ3PR DI DMLQ3PR DMLQ3PR DN Tyr-Pro-Phe-D-2-Nal-NH2 DMLQ3PR MI TTKWM86 DMLQ3PR MN Opioid receptor mu (MOP) DMLQ3PR MT DTT DMLQ3PR MA Inhibitor DMLQ3PR RN Novel highly potent mu-opioid receptor antagonist based on endomorphin-2 structure. Bioorg Med Chem Lett. 2008 Feb 15;18(4):1350-3. DMLQ3PR RU https://pubmed.ncbi.nlm.nih.gov/18207400 DMLEUF6 DI DMLEUF6 DMLEUF6 DN Tyr-Pro-Phe-D-Ala-Bn DMLEUF6 MI TTKWM86 DMLEUF6 MN Opioid receptor mu (MOP) DMLEUF6 MT DTT DMLEUF6 MA Inhibitor DMLEUF6 RN Molecular modeling studies to predict the possible binding modes of endomorphin analogs in mu opioid receptor. Bioorg Med Chem Lett. 2009 Sep 15;19(18):5387-91. DMLEUF6 RU https://pubmed.ncbi.nlm.nih.gov/19679474 DM6YRVT DI DM6YRVT DM6YRVT DN Tyr-Pro-Phe-D-Phg-NH2 DM6YRVT MI TTKWM86 DM6YRVT MN Opioid receptor mu (MOP) DM6YRVT MT DTT DM6YRVT MA Inhibitor DM6YRVT RN Opioid receptor binding and antinociceptive activity of the analogues of endomorphin-2 and morphiceptin with phenylalanine mimics in the position 3... Bioorg Med Chem Lett. 2006 Jul 15;16(14):3688-92. DM6YRVT RU https://pubmed.ncbi.nlm.nih.gov/16682191 DM1QZ9X DI DM1QZ9X DM1QZ9X DN Tyr-Pro-Phe-D-Val-Bn DM1QZ9X MI TTKWM86 DM1QZ9X MN Opioid receptor mu (MOP) DM1QZ9X MT DTT DM1QZ9X MA Inhibitor DM1QZ9X RN Molecular modeling studies to predict the possible binding modes of endomorphin analogs in mu opioid receptor. Bioorg Med Chem Lett. 2009 Sep 15;19(18):5387-91. DM1QZ9X RU https://pubmed.ncbi.nlm.nih.gov/19679474 DM71P2O DI DM71P2O DM71P2O DN Tyr-Pro-Phe-Hfe-NH2 DM71P2O MI TTKWM86 DM71P2O MN Opioid receptor mu (MOP) DM71P2O MT DTT DM71P2O MA Inhibitor DM71P2O RN Opioid receptor binding and antinociceptive activity of the analogues of endomorphin-2 and morphiceptin with phenylalanine mimics in the position 3... Bioorg Med Chem Lett. 2006 Jul 15;16(14):3688-92. DM71P2O RU https://pubmed.ncbi.nlm.nih.gov/16682191 DM5DRIZ DI DM5DRIZ DM5DRIZ DN Tyr-Pro-Phe-Phe-N(CH3)2 DM5DRIZ MI TT27RFC DM5DRIZ MN Opioid receptor delta (OPRD1) DM5DRIZ MT DTT DM5DRIZ MA Inhibitor DM5DRIZ RN Structure-activity study of endomorphin-2 analogs with C-terminal modifications by NMR spectroscopy and molecular modeling. Bioorg Med Chem. 2008 Jun 15;16(12):6415-22. DM5DRIZ RU https://pubmed.ncbi.nlm.nih.gov/18490168 DM5DRIZ DI DM5DRIZ DM5DRIZ DN Tyr-Pro-Phe-Phe-N(CH3)2 DM5DRIZ MI TTKWM86 DM5DRIZ MN Opioid receptor mu (MOP) DM5DRIZ MT DTT DM5DRIZ MA Inhibitor DM5DRIZ RN Structure-activity study of endomorphin-2 analogs with C-terminal modifications by NMR spectroscopy and molecular modeling. Bioorg Med Chem. 2008 Jun 15;16(12):6415-22. DM5DRIZ RU https://pubmed.ncbi.nlm.nih.gov/18490168 DM2U4VI DI DM2U4VI DM2U4VI DN Tyr-Pro-Phe-Phe-NHCH3 DM2U4VI MI TT27RFC DM2U4VI MN Opioid receptor delta (OPRD1) DM2U4VI MT DTT DM2U4VI MA Inhibitor DM2U4VI RN Structure-activity study of endomorphin-2 analogs with C-terminal modifications by NMR spectroscopy and molecular modeling. Bioorg Med Chem. 2008 Jun 15;16(12):6415-22. DM2U4VI RU https://pubmed.ncbi.nlm.nih.gov/18490168 DM2U4VI DI DM2U4VI DM2U4VI DN Tyr-Pro-Phe-Phe-NHCH3 DM2U4VI MI TTKWM86 DM2U4VI MN Opioid receptor mu (MOP) DM2U4VI MT DTT DM2U4VI MA Inhibitor DM2U4VI RN Structure-activity study of endomorphin-2 analogs with C-terminal modifications by NMR spectroscopy and molecular modeling. Bioorg Med Chem. 2008 Jun 15;16(12):6415-22. DM2U4VI RU https://pubmed.ncbi.nlm.nih.gov/18490168 DMY6V9R DI DMY6V9R DMY6V9R DN Tyr-Pro-Phe-Phe-NHNH2 DMY6V9R MI TT27RFC DMY6V9R MN Opioid receptor delta (OPRD1) DMY6V9R MT DTT DMY6V9R MA Inhibitor DMY6V9R RN Structure-activity study of endomorphin-2 analogs with C-terminal modifications by NMR spectroscopy and molecular modeling. Bioorg Med Chem. 2008 Jun 15;16(12):6415-22. DMY6V9R RU https://pubmed.ncbi.nlm.nih.gov/18490168 DMY6V9R DI DMY6V9R DMY6V9R DN Tyr-Pro-Phe-Phe-NHNH2 DMY6V9R MI TTKWM86 DMY6V9R MN Opioid receptor mu (MOP) DMY6V9R MT DTT DMY6V9R MA Inhibitor DMY6V9R RN Structure-activity study of endomorphin-2 analogs with C-terminal modifications by NMR spectroscopy and molecular modeling. Bioorg Med Chem. 2008 Jun 15;16(12):6415-22. DMY6V9R RU https://pubmed.ncbi.nlm.nih.gov/18490168 DMS4P1E DI DMS4P1E DMS4P1E DN Tyr-Pro-Phe-Phe-OC(CH3)3 DMS4P1E MI TT27RFC DMS4P1E MN Opioid receptor delta (OPRD1) DMS4P1E MT DTT DMS4P1E MA Inhibitor DMS4P1E RN Structure-activity study of endomorphin-2 analogs with C-terminal modifications by NMR spectroscopy and molecular modeling. Bioorg Med Chem. 2008 Jun 15;16(12):6415-22. DMS4P1E RU https://pubmed.ncbi.nlm.nih.gov/18490168 DMS4P1E DI DMS4P1E DMS4P1E DN Tyr-Pro-Phe-Phe-OC(CH3)3 DMS4P1E MI TTKWM86 DMS4P1E MN Opioid receptor mu (MOP) DMS4P1E MT DTT DMS4P1E MA Inhibitor DMS4P1E RN Structure-activity study of endomorphin-2 analogs with C-terminal modifications by NMR spectroscopy and molecular modeling. Bioorg Med Chem. 2008 Jun 15;16(12):6415-22. DMS4P1E RU https://pubmed.ncbi.nlm.nih.gov/18490168 DMZNHEC DI DMZNHEC DMZNHEC DN Tyr-Pro-Phe-Phe-OCH2CH3 DMZNHEC MI TT27RFC DMZNHEC MN Opioid receptor delta (OPRD1) DMZNHEC MT DTT DMZNHEC MA Inhibitor DMZNHEC RN Structure-activity study of endomorphin-2 analogs with C-terminal modifications by NMR spectroscopy and molecular modeling. Bioorg Med Chem. 2008 Jun 15;16(12):6415-22. DMZNHEC RU https://pubmed.ncbi.nlm.nih.gov/18490168 DMZNHEC DI DMZNHEC DMZNHEC DN Tyr-Pro-Phe-Phe-OCH2CH3 DMZNHEC MI TTKWM86 DMZNHEC MN Opioid receptor mu (MOP) DMZNHEC MT DTT DMZNHEC MA Inhibitor DMZNHEC RN Structure-activity study of endomorphin-2 analogs with C-terminal modifications by NMR spectroscopy and molecular modeling. Bioorg Med Chem. 2008 Jun 15;16(12):6415-22. DMZNHEC RU https://pubmed.ncbi.nlm.nih.gov/18490168 DMFV7NI DI DMFV7NI DMFV7NI DN Tyr-Pro-Phe-Phe-OCH2OH DMFV7NI MI TT27RFC DMFV7NI MN Opioid receptor delta (OPRD1) DMFV7NI MT DTT DMFV7NI MA Inhibitor DMFV7NI RN Structure-activity study of endomorphin-2 analogs with C-terminal modifications by NMR spectroscopy and molecular modeling. Bioorg Med Chem. 2008 Jun 15;16(12):6415-22. DMFV7NI RU https://pubmed.ncbi.nlm.nih.gov/18490168 DMFV7NI DI DMFV7NI DMFV7NI DN Tyr-Pro-Phe-Phe-OCH2OH DMFV7NI MI TTKWM86 DMFV7NI MN Opioid receptor mu (MOP) DMFV7NI MT DTT DMFV7NI MA Inhibitor DMFV7NI RN Structure-activity study of endomorphin-2 analogs with C-terminal modifications by NMR spectroscopy and molecular modeling. Bioorg Med Chem. 2008 Jun 15;16(12):6415-22. DMFV7NI RU https://pubmed.ncbi.nlm.nih.gov/18490168 DMRQXHO DI DMRQXHO DMRQXHO DN Tyr-Pro-Phe-Phe-OCH3 DMRQXHO MI TT27RFC DMRQXHO MN Opioid receptor delta (OPRD1) DMRQXHO MT DTT DMRQXHO MA Inhibitor DMRQXHO RN Structure-activity study of endomorphin-2 analogs with C-terminal modifications by NMR spectroscopy and molecular modeling. Bioorg Med Chem. 2008 Jun 15;16(12):6415-22. DMRQXHO RU https://pubmed.ncbi.nlm.nih.gov/18490168 DMRQXHO DI DMRQXHO DMRQXHO DN Tyr-Pro-Phe-Phe-OCH3 DMRQXHO MI TTKWM86 DMRQXHO MN Opioid receptor mu (MOP) DMRQXHO MT DTT DMRQXHO MA Inhibitor DMRQXHO RN Structure-activity study of endomorphin-2 analogs with C-terminal modifications by NMR spectroscopy and molecular modeling. Bioorg Med Chem. 2008 Jun 15;16(12):6415-22. DMRQXHO RU https://pubmed.ncbi.nlm.nih.gov/18490168 DM70HYT DI DM70HYT DM70HYT DN Tyr-Pro-Phe-Phg-NH2 DM70HYT MI TTKWM86 DM70HYT MN Opioid receptor mu (MOP) DM70HYT MT DTT DM70HYT MA Inhibitor DM70HYT RN Opioid receptor binding and antinociceptive activity of the analogues of endomorphin-2 and morphiceptin with phenylalanine mimics in the position 3... Bioorg Med Chem Lett. 2006 Jul 15;16(14):3688-92. DM70HYT RU https://pubmed.ncbi.nlm.nih.gov/16682191 DMVDM73 DI DMVDM73 DMVDM73 DN Tyr-Pro-Phg-Phe-NH2 DMVDM73 MI TTKWM86 DMVDM73 MN Opioid receptor mu (MOP) DMVDM73 MT DTT DMVDM73 MA Inhibitor DMVDM73 RN Opioid receptor binding and antinociceptive activity of the analogues of endomorphin-2 and morphiceptin with phenylalanine mimics in the position 3... Bioorg Med Chem Lett. 2006 Jul 15;16(14):3688-92. DMVDM73 RU https://pubmed.ncbi.nlm.nih.gov/16682191 DMSGMPU DI DMSGMPU DMSGMPU DN Tyr-Pro-Phg-Pro-NH2 DMSGMPU MI TTKWM86 DMSGMPU MN Opioid receptor mu (MOP) DMSGMPU MT DTT DMSGMPU MA Inhibitor DMSGMPU RN Opioid receptor binding and antinociceptive activity of the analogues of endomorphin-2 and morphiceptin with phenylalanine mimics in the position 3... Bioorg Med Chem Lett. 2006 Jul 15;16(14):3688-92. DMSGMPU RU https://pubmed.ncbi.nlm.nih.gov/16682191 DMR3IVB DI DMR3IVB DMR3IVB DN Tyr-Pro-Tmp-Phe-NH DMR3IVB MI TT27RFC DMR3IVB MN Opioid receptor delta (OPRD1) DMR3IVB MT DTT DMR3IVB MA Inhibitor DMR3IVB RN Bifunctional [2',6'-dimethyl-L-tyrosine1]endomorphin-2 analogues substituted at position 3 with alkylated phenylalanine derivatives yield potent mi... J Med Chem. 2007 Jun 14;50(12):2753-66. DMR3IVB RU https://pubmed.ncbi.nlm.nih.gov/17497839 DMR3IVB DI DMR3IVB DMR3IVB DN Tyr-Pro-Tmp-Phe-NH DMR3IVB MI TTKWM86 DMR3IVB MN Opioid receptor mu (MOP) DMR3IVB MT DTT DMR3IVB MA Inhibitor DMR3IVB RN Bifunctional [2',6'-dimethyl-L-tyrosine1]endomorphin-2 analogues substituted at position 3 with alkylated phenylalanine derivatives yield potent mi... J Med Chem. 2007 Jun 14;50(12):2753-66. DMR3IVB RU https://pubmed.ncbi.nlm.nih.gov/17497839 DMFIPXA DI DMFIPXA DMFIPXA DN Tyr-Pro-Trp-D-Ala-Bn DMFIPXA MI TTKWM86 DMFIPXA MN Opioid receptor mu (MOP) DMFIPXA MT DTT DMFIPXA MA Inhibitor DMFIPXA RN Molecular modeling studies to predict the possible binding modes of endomorphin analogs in mu opioid receptor. Bioorg Med Chem Lett. 2009 Sep 15;19(18):5387-91. DMFIPXA RU https://pubmed.ncbi.nlm.nih.gov/19679474 DMY5HX6 DI DMY5HX6 DMY5HX6 DN Tyr-Pro-Trp-D-Val-Bn DMY5HX6 MI TTKWM86 DMY5HX6 MN Opioid receptor mu (MOP) DMY5HX6 MT DTT DMY5HX6 MA Inhibitor DMY5HX6 RN Molecular modeling studies to predict the possible binding modes of endomorphin analogs in mu opioid receptor. Bioorg Med Chem Lett. 2009 Sep 15;19(18):5387-91. DMY5HX6 RU https://pubmed.ncbi.nlm.nih.gov/19679474 DMKLDWF DI DMKLDWF DMKLDWF DN Tyr-Pro-Trp-Gly-Bn DMKLDWF MI TTKWM86 DMKLDWF MN Opioid receptor mu (MOP) DMKLDWF MT DTT DMKLDWF MA Inhibitor DMKLDWF RN Molecular modeling studies to predict the possible binding modes of endomorphin analogs in mu opioid receptor. Bioorg Med Chem Lett. 2009 Sep 15;19(18):5387-91. DMKLDWF RU https://pubmed.ncbi.nlm.nih.gov/19679474 DMIZB25 DI DMIZB25 DMIZB25 DN Tyr-Sar-Phe-D-2-Nal-NH2 DMIZB25 MI TTKWM86 DMIZB25 MN Opioid receptor mu (MOP) DMIZB25 MT DTT DMIZB25 MA Inhibitor DMIZB25 RN Novel highly potent mu-opioid receptor antagonist based on endomorphin-2 structure. Bioorg Med Chem Lett. 2008 Feb 15;18(4):1350-3. DMIZB25 RU https://pubmed.ncbi.nlm.nih.gov/18207400 DMVCHOX DI DMVCHOX DMVCHOX DN TZD18 DMVCHOX MI TTJ584C DMVCHOX MN Peroxisome proliferator-activated receptor alpha (PPARA) DMVCHOX MT DTT DMVCHOX MA Agonist DMVCHOX RN A novel peroxisome proliferator-activated receptor alpha/gamma dual agonist demonstrates favorable effects on lipid homeostasis. Endocrinology. 2004 Apr;145(4):1640-8. DMVCHOX RU https://pubmed.ncbi.nlm.nih.gov/14701675 DMVCHOX DI DMVCHOX DMVCHOX DN TZD18 DMVCHOX MI TTT2SVW DMVCHOX MN PPAR-gamma messenger RNA (PPARG mRNA) DMVCHOX MT DTT DMVCHOX MA Agonist DMVCHOX RN A novel peroxisome proliferator-activated receptor alpha/gamma dual agonist demonstrates favorable effects on lipid homeostasis. Endocrinology. 2004 Apr;145(4):1640-8. DMVCHOX RU https://pubmed.ncbi.nlm.nih.gov/14701675 DMSI0HE DI DMSI0HE DMSI0HE DN TZI-41127 DMSI0HE MI TT2J34L DMSI0HE MN Arachidonate 5-lipoxygenase (5-LOX) DMSI0HE MT DTT DMSI0HE MA Inhibitor DMSI0HE RN Design of pyrrolo-1,4-benzoxazine derivatives as inhibitors of 5-lipoxygenase and PAF antagonists with anthihistaminic properties, Bioorg. Med. Chem. Lett. 4(20):2383-2388 (1994). DMSI0HE RU http://www.sciencedirect.com/science/article/pii/S0960894X01803954 DMD6CLG DI DMD6CLG DMD6CLG DN TZP-201 DMD6CLG MI TT953CX DMD6CLG MN Motilin receptor (MLNR) DMD6CLG MT DTT DMD6CLG MA Antagonist DMD6CLG RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 297). DMD6CLG RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=297 DM31OGF DI DM31OGF DM31OGF DN U0126 DM31OGF MI TTQBCEJ DM31OGF MN MAPK/ERK kinase kinase 1 (MAP3K1) DM31OGF MT DTT DM31OGF MA Inhibitor DM31OGF RN Pharmacological inhibitors of MAPK pathways. Trends Pharmacol Sci. 2002 Jan;23(1):40-5. DM31OGF RU https://pubmed.ncbi.nlm.nih.gov/11804650 DM31OGF DI DM31OGF DM31OGF DN U0126 DM31OGF MI TTK1N5G DM31OGF MN MAPK/ERK kinase kinase 2 (MAP3K2) DM31OGF MT DTT DM31OGF MA Inhibitor DM31OGF RN Pharmacological inhibitors of MAPK pathways. Trends Pharmacol Sci. 2002 Jan;23(1):40-5. DM31OGF RU https://pubmed.ncbi.nlm.nih.gov/11804650 DM31OGF DI DM31OGF DM31OGF DN U0126 DM31OGF MI TTVOE6D DM31OGF MN Mitogen-activated protein kinase (MAPK) DM31OGF MT DTT DM31OGF MA Inhibitor DM31OGF RN Intravenous administration of MEK inhibitor U0126 affords brain protection against forebrain ischemia and focal cerebral ischemia. Proc Natl Acad Sci U S A. 2001 Sep 25;98(20):11569-74. DM31OGF RU https://pubmed.ncbi.nlm.nih.gov/11504919 DM31OGF DI DM31OGF DM31OGF DN U0126 DM31OGF MI TTCZO0Q DM31OGF MN Mitogen-activated protein kinase kinase (MAPKK) DM31OGF MT DTT DM31OGF MA Inhibitor DM31OGF RN Transcriptional regulation of basal cyclooxygenase-2 expression in murine lung tumor-derived cell lines by CCAAT/enhancer-binding protein and activating transcription factor/cAMP response element-binding protein. Mol Pharmacol. 2002 Aug;62(2):326-33. DM31OGF RU https://pubmed.ncbi.nlm.nih.gov/12130685 DM9GOAV DI DM9GOAV DM9GOAV DN U101958 DM9GOAV MI TTE0A2F DM9GOAV MN Dopamine D4 receptor (D4R) DM9GOAV MT DTT DM9GOAV MA Antagonist DM9GOAV RN Substituted 4-aminopiperidines having high in vitro affinity and selectivity for the cloned human dopamine D4 receptor. Eur J Pharmacol. 1997 Mar 19;322(2-3):283-6. DM9GOAV RU https://pubmed.ncbi.nlm.nih.gov/9098699 DM0DMNS DI DM0DMNS DM0DMNS DN U-44069 DM0DMNS MI TT2O84V DM0DMNS MN Thromboxane A2 receptor (TBXA2R) DM0DMNS MT DTT DM0DMNS MA Inhibitor DM0DMNS RN cis-4-(Piperazin-1-yl)-5,6,7a,8,9,10,11,11a-octahydrobenzofuro[2,3-h]quinazolin-2-amine (A-987306), a new histamine H4R antagonist that blocks pain... J Med Chem. 2008 Nov 27;51(22):7094-8. DM0DMNS RU https://pubmed.ncbi.nlm.nih.gov/18983139 DM13FX4 DI DM13FX4 DM13FX4 DN U46619 DM13FX4 MI TTOFYT1 DM13FX4 MN Prostacyclin receptor (PTGIR) DM13FX4 MT DTT DM13FX4 MA Agonist DM13FX4 RN The utilization of recombinant prostanoid receptors to determine the affinities and selectivities of prostaglandins and related analogs. Biochim Biophys Acta. 2000 Jan 17;1483(2):285-93. DM13FX4 RU https://pubmed.ncbi.nlm.nih.gov/10634944 DM13FX4 DI DM13FX4 DM13FX4 DN U46619 DM13FX4 MI TTNVEIR DM13FX4 MN Prostaglandin D2 receptor (PTGDR) DM13FX4 MT DTT DM13FX4 MA Agonist DM13FX4 RN The utilization of recombinant prostanoid receptors to determine the affinities and selectivities of prostaglandins and related analogs. Biochim Biophys Acta. 2000 Jan 17;1483(2):285-93. DM13FX4 RU https://pubmed.ncbi.nlm.nih.gov/10634944 DM13FX4 DI DM13FX4 DM13FX4 DN U46619 DM13FX4 MI TTQDMX5 DM13FX4 MN Prostaglandin D2 receptor 2 (PTGDR2) DM13FX4 MT DTT DM13FX4 MA Agonist DM13FX4 RN Molecular pharmacology of the human prostaglandin D2 receptor, CRTH2. Br J Pharmacol. 2002 Dec;137(8):1163-72. DM13FX4 RU https://pubmed.ncbi.nlm.nih.gov/12466225 DM13FX4 DI DM13FX4 DM13FX4 DN U46619 DM13FX4 MI TTG1QMU DM13FX4 MN Prostaglandin E2 receptor EP1 (PTGER1) DM13FX4 MT DTT DM13FX4 MA Agonist DM13FX4 RN Molecular cloning and characterization of the four rat prostaglandin E2 prostanoid receptor subtypes. Eur J Pharmacol. 1997 Dec 11;340(2-3):227-41. DM13FX4 RU https://pubmed.ncbi.nlm.nih.gov/9537820 DM13FX4 DI DM13FX4 DM13FX4 DN U46619 DM13FX4 MI TT1ZAVI DM13FX4 MN Prostaglandin E2 receptor EP2 (PTGER2) DM13FX4 MT DTT DM13FX4 MA Agonist DM13FX4 RN Molecular cloning and characterization of the four rat prostaglandin E2 prostanoid receptor subtypes. Eur J Pharmacol. 1997 Dec 11;340(2-3):227-41. DM13FX4 RU https://pubmed.ncbi.nlm.nih.gov/9537820 DM13FX4 DI DM13FX4 DM13FX4 DN U46619 DM13FX4 MI TTPNGDE DM13FX4 MN Prostaglandin E2 receptor EP3 (PTGER3) DM13FX4 MT DTT DM13FX4 MA Agonist DM13FX4 RN The utilization of recombinant prostanoid receptors to determine the affinities and selectivities of prostaglandins and related analogs. Biochim Biophys Acta. 2000 Jan 17;1483(2):285-93. DM13FX4 RU https://pubmed.ncbi.nlm.nih.gov/10634944 DM13FX4 DI DM13FX4 DM13FX4 DN U46619 DM13FX4 MI TT79WV3 DM13FX4 MN Prostaglandin E2 receptor EP4 (PTGER4) DM13FX4 MT DTT DM13FX4 MA Agonist DM13FX4 RN Molecular cloning and characterization of the four rat prostaglandin E2 prostanoid receptor subtypes. Eur J Pharmacol. 1997 Dec 11;340(2-3):227-41. DM13FX4 RU https://pubmed.ncbi.nlm.nih.gov/9537820 DM13FX4 DI DM13FX4 DM13FX4 DN U46619 DM13FX4 MI TTT2ZAR DM13FX4 MN Prostaglandin F2-alpha receptor (PTGFR) DM13FX4 MT DTT DM13FX4 MA Agonist DM13FX4 RN The utilization of recombinant prostanoid receptors to determine the affinities and selectivities of prostaglandins and related analogs. Biochim Biophys Acta. 2000 Jan 17;1483(2):285-93. DM13FX4 RU https://pubmed.ncbi.nlm.nih.gov/10634944 DM13FX4 DI DM13FX4 DM13FX4 DN U46619 DM13FX4 MI TT2O84V DM13FX4 MN Thromboxane A2 receptor (TBXA2R) DM13FX4 MT DTT DM13FX4 MA Agonist DM13FX4 RN The utilization of recombinant prostanoid receptors to determine the affinities and selectivities of prostaglandins and related analogs. Biochim Biophys Acta. 2000 Jan 17;1483(2):285-93. DM13FX4 RU https://pubmed.ncbi.nlm.nih.gov/10634944 DMYW1VP DI DMYW1VP DMYW1VP DN U50,488H DMYW1VP MI TTQW87Y DMYW1VP MN Opioid receptor kappa (OPRK1) DMYW1VP MT DTT DMYW1VP MA Agonist DMYW1VP RN The selective kappa-opioid receptor agonist U50,488H attenuates voluntary ethanol intake in the rat. Behav Brain Res. 2001 May;120(2):137-46. DMYW1VP RU https://pubmed.ncbi.nlm.nih.gov/11182162 DMQT6AH DI DMQT6AH DMQT6AH DN U-89267 DMQT6AH MI TT1MPAY DMQT6AH MN GABA(A) receptor alpha-1 (GABRA1) DMQT6AH MT DTT DMQT6AH MA Inhibitor DMQT6AH RN Antagonist, partial agonist, and full agonist imidazo[1,5-a]quinoxaline amides and carbamates acting through the GABAA/benzodiazepine receptor. J Med Chem. 1994 Mar 18;37(6):758-68. DMQT6AH RU https://pubmed.ncbi.nlm.nih.gov/8145225 DMQT6AH DI DMQT6AH DMQT6AH DN U-89267 DMQT6AH MI TTZA1NY DMQT6AH MN GABA(A) receptor beta-2 (GABRB2) DMQT6AH MT DTT DMQT6AH MA Inhibitor DMQT6AH RN Antagonist, partial agonist, and full agonist imidazo[1,5-a]quinoxaline amides and carbamates acting through the GABAA/benzodiazepine receptor. J Med Chem. 1994 Mar 18;37(6):758-68. DMQT6AH RU https://pubmed.ncbi.nlm.nih.gov/8145225 DMQT6AH DI DMQT6AH DMQT6AH DN U-89267 DMQT6AH MI TT06RH5 DMQT6AH MN GABA(A) receptor gamma-2 (GABRG2) DMQT6AH MT DTT DMQT6AH MA Inhibitor DMQT6AH RN Antagonist, partial agonist, and full agonist imidazo[1,5-a]quinoxaline amides and carbamates acting through the GABAA/benzodiazepine receptor. J Med Chem. 1994 Mar 18;37(6):758-68. DMQT6AH RU https://pubmed.ncbi.nlm.nih.gov/8145225 DMQT6AH DI DMQT6AH DMQT6AH DN U-89267 DMQT6AH MI TTNJYV2 DMQT6AH MN Gamma-aminobutyric acid receptor (GAR) DMQT6AH MT DTT DMQT6AH MA Inhibitor DMQT6AH RN Antagonist, partial agonist, and full agonist imidazo[1,5-a]quinoxaline amides and carbamates acting through the GABAA/benzodiazepine receptor. J Med Chem. 1994 Mar 18;37(6):758-68. DMQT6AH RU https://pubmed.ncbi.nlm.nih.gov/8145225 DMI6VAX DI DMI6VAX DMI6VAX DN U-89854 DMI6VAX MI TTPTXIN DMI6VAX MN Translocator protein (TSPO) DMI6VAX MT DTT DMI6VAX MA Modulator DMI6VAX RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2879). DMI6VAX RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2879 DM7CJNE DI DM7CJNE DM7CJNE DN U92016A DM7CJNE MI TTSQIFT DM7CJNE MN 5-HT 1A receptor (HTR1A) DM7CJNE MT DTT DM7CJNE MA Agonist DM7CJNE RN Characterization of U-92016A as a selective, orally active, high intrinsic activity 5-hydroxytryptamine1A agonist. J Pharmacol Exp Ther. 1994 Nov;271(2):875-83. DM7CJNE RU https://pubmed.ncbi.nlm.nih.gov/7965808 DMLUP30 DI DMLUP30 DMLUP30 DN UBIQUINONE-2 DMLUP30 MI TTRAMF0 DMLUP30 MN Plasmodium Cytochrome B (Malaria MT-CYB) DMLUP30 MT DTT DMLUP30 MA Inhibitor DMLUP30 RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DMLUP30 RU https://pubmed.ncbi.nlm.nih.gov/10592235 DM6IG5J DI DM6IG5J DM6IG5J DN UBP141 DM6IG5J MI TTKJEMQ DM6IG5J MN Glutamate receptor ionotropic NMDA 2A (NMDAR2A) DM6IG5J MT DTT DM6IG5J MA Antagonist DM6IG5J RN Synthesis and pharmacology of N1-substituted piperazine-2,3-dicarboxylic acid derivatives acting as NMDA receptor antagonists. J Med Chem. 2005 Apr 7;48(7):2627-37. DM6IG5J RU https://pubmed.ncbi.nlm.nih.gov/15801853 DM6IG5J DI DM6IG5J DM6IG5J DN UBP141 DM6IG5J MI TTN9D8E DM6IG5J MN Glutamate receptor ionotropic NMDA 2B (NMDAR2B) DM6IG5J MT DTT DM6IG5J MA Antagonist DM6IG5J RN Synthesis and pharmacology of N1-substituted piperazine-2,3-dicarboxylic acid derivatives acting as NMDA receptor antagonists. J Med Chem. 2005 Apr 7;48(7):2627-37. DM6IG5J RU https://pubmed.ncbi.nlm.nih.gov/15801853 DM6IG5J DI DM6IG5J DM6IG5J DN UBP141 DM6IG5J MI TT1M8OW DM6IG5J MN Glutamate receptor ionotropic NMDA 2C (GluN2C) DM6IG5J MT DTT DM6IG5J MA Antagonist DM6IG5J RN Synthesis and pharmacology of N1-substituted piperazine-2,3-dicarboxylic acid derivatives acting as NMDA receptor antagonists. J Med Chem. 2005 Apr 7;48(7):2627-37. DM6IG5J RU https://pubmed.ncbi.nlm.nih.gov/15801853 DM6IG5J DI DM6IG5J DM6IG5J DN UBP141 DM6IG5J MI TT5POTG DM6IG5J MN Glutamate receptor ionotropic NMDA 2D (GluN2D) DM6IG5J MT DTT DM6IG5J MA Antagonist DM6IG5J RN Synthesis and pharmacology of N1-substituted piperazine-2,3-dicarboxylic acid derivatives acting as NMDA receptor antagonists. J Med Chem. 2005 Apr 7;48(7):2627-37. DM6IG5J RU https://pubmed.ncbi.nlm.nih.gov/15801853 DMSJLX0 DI DMSJLX0 DMSJLX0 DN UBP-302 DMSJLX0 MI TT0MYE2 DMSJLX0 MN Glutamate receptor ionotropic kainate 1 (GRIK1) DMSJLX0 MT DTT DMSJLX0 MA Inhibitor DMSJLX0 RN Structural investigation of the 7-chloro-3-hydroxy-1H-quinazoline-2,4-dione scaffold to obtain AMPA and kainate receptor selective antagonists. Syn... J Med Chem. 2006 Oct 5;49(20):6015-26. DMSJLX0 RU https://pubmed.ncbi.nlm.nih.gov/17004715 DMVQL3J DI DMVQL3J DMVQL3J DN UBP310 DMVQL3J MI TT0MYE2 DMVQL3J MN Glutamate receptor ionotropic kainate 1 (GRIK1) DMVQL3J MT DTT DMVQL3J MA Antagonist DMVQL3J RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 450). DMVQL3J RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=450 DMVQL3J DI DMVQL3J DMVQL3J DN UBP310 DMVQL3J MI TTNP6O2 DMVQL3J MN Glutamate receptor ionotropic kainate 3 (GluK3) DMVQL3J MT DTT DMVQL3J MA Antagonist DMVQL3J RN Mapping the ligand binding sites of kainate receptors: molecular determinants of subunit-selective binding of the antagonist [3H]UBP310. Mol Pharmacol. 2010 Dec;78(6):1036-45. DMVQL3J RU https://pubmed.ncbi.nlm.nih.gov/20837679 DMCRFT5 DI DMCRFT5 DMCRFT5 DN UC-1011 DMCRFT5 MI TTEX6LM DMCRFT5 MN GABA(A) receptor gamma-3 (GABRG3) DMCRFT5 MT DTT DMCRFT5 MA Antagonist DMCRFT5 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 415). DMCRFT5 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=415 DMJVT4K DI DMJVT4K DMJVT4K DN UC-2024 DMJVT4K MI TTEX6LM DMJVT4K MN GABA(A) receptor gamma-3 (GABRG3) DMJVT4K MT DTT DMJVT4K MA Modulator DMJVT4K RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 415). DMJVT4K RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=415 DMGSOZ7 DI DMGSOZ7 DMGSOZ7 DN UC-2029 DMGSOZ7 MI TTEX6LM DMGSOZ7 MN GABA(A) receptor gamma-3 (GABRG3) DMGSOZ7 MT DTT DMGSOZ7 MA Modulator DMGSOZ7 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 415). DMGSOZ7 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=415 DMHYORU DI DMHYORU DMHYORU DN UCB-101333-3 DMHYORU MI TTQ13Z5 DMHYORU MN Muscarinic acetylcholine receptor M3 (CHRM3) DMHYORU MT DTT DMHYORU MA Inhibitor DMHYORU RN Dual M3 antagonists-PDE4 inhibitors. Part 2: Synthesis and SAR of 3-substituted azetidinyl derivatives. Bioorg Med Chem Lett. 2007 Jun 1;17(11):3077-80. DMHYORU RU https://pubmed.ncbi.nlm.nih.gov/17398090 DMHYORU DI DMHYORU DMHYORU DN UCB-101333-3 DMHYORU MI TTZ97H5 DMHYORU MN Phosphodiesterase 4A (PDE4A) DMHYORU MT DTT DMHYORU MA Inhibitor DMHYORU RN First dual M3 antagonists-PDE4 inhibitors: synthesis and SAR of 4,6-diaminopyrimidine derivatives. Bioorg Med Chem Lett. 2006 Apr 1;16(7):1834-9. DMHYORU RU https://pubmed.ncbi.nlm.nih.gov/16439121 DMHYORU DI DMHYORU DMHYORU DN UCB-101333-3 DMHYORU MI TTVIAT9 DMHYORU MN Phosphodiesterase 4B (PDE4B) DMHYORU MT DTT DMHYORU MA Inhibitor DMHYORU RN First dual M3 antagonists-PDE4 inhibitors: synthesis and SAR of 4,6-diaminopyrimidine derivatives. Bioorg Med Chem Lett. 2006 Apr 1;16(7):1834-9. DMHYORU RU https://pubmed.ncbi.nlm.nih.gov/16439121 DMHYORU DI DMHYORU DMHYORU DN UCB-101333-3 DMHYORU MI TTSKMI8 DMHYORU MN Phosphodiesterase 4D (PDE4D) DMHYORU MT DTT DMHYORU MA Inhibitor DMHYORU RN First dual M3 antagonists-PDE4 inhibitors: synthesis and SAR of 4,6-diaminopyrimidine derivatives. Bioorg Med Chem Lett. 2006 Apr 1;16(7):1834-9. DMHYORU RU https://pubmed.ncbi.nlm.nih.gov/16439121 DMFUE43 DI DMFUE43 DMFUE43 DN UCB-1277763 DMFUE43 MI TTQBR95 DMFUE43 MN Stress-activated protein kinase 2a (p38 alpha) DMFUE43 MT DTT DMFUE43 MA Inhibitor DMFUE43 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1499). DMFUE43 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1499 DMQ20A4 DI DMQ20A4 DMQ20A4 DN UCB-2892 DMQ20A4 MI TT9JNIC DMQ20A4 MN Histamine H3 receptor (H3R) DMQ20A4 MT DTT DMQ20A4 MA Antagonist DMQ20A4 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 264). DMQ20A4 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=264 DMQB8C3 DI DMQB8C3 DMQB8C3 DN UCB35625 DMQB8C3 MI TT8KLPT DMQB8C3 MN C-C chemokine receptor (CCR) DMQB8C3 MT DTT DMQB8C3 MA Antagonist DMQB8C3 RN A small molecule antagonist of chemokine receptors CCR1 and CCR3. Potent inhibition of eosinophil function and CCR3-mediated HIV-1 entry. J Biol Chem. 2000 Aug 25;275(34):25985-92. DMQB8C3 RU https://pubmed.ncbi.nlm.nih.gov/10854442 DMO9S5P DI DMO9S5P DMO9S5P DN UCCF-029 DMO9S5P MI TTRLZHP DMO9S5P MN cAMP-dependent chloride channel (CFTR) DMO9S5P MT DTT DMO9S5P MA Activator DMO9S5P RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 707). DMO9S5P RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=707 DM3I9JG DI DM3I9JG DM3I9JG DN UCCF-339 DM3I9JG MI TTRLZHP DM3I9JG MN cAMP-dependent chloride channel (CFTR) DM3I9JG MT DTT DM3I9JG MA Activator DM3I9JG RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 707). DM3I9JG RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=707 DMN9QO4 DI DMN9QO4 DMN9QO4 DN UCCF-853 DMN9QO4 MI TTRLZHP DMN9QO4 MN cAMP-dependent chloride channel (CFTR) DMN9QO4 MT DTT DMN9QO4 MA Activator DMN9QO4 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 707). DMN9QO4 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=707 DMZNJFU DI DMZNJFU DMZNJFU DN UCL1684 DMZNJFU MI TT9R6BE DMZNJFU MN Calcium-activated potassium channel KCa2.1 (KCNN1) DMZNJFU MT DTT DMZNJFU MA Blocker (channel blocker) DMZNJFU RN Small conductance calcium-activated potassium channels: from structure to function. Prog Neurobiol. 2010 Jul;91(3):242-55. DMZNJFU RU https://pubmed.ncbi.nlm.nih.gov/20359520 DMZNJFU DI DMZNJFU DMZNJFU DN UCL1684 DMZNJFU MI TT2T5M0 DMZNJFU MN Calcium-activated potassium channel KCa2.2 (KCNN2) DMZNJFU MT DTT DMZNJFU MA Blocker (channel blocker) DMZNJFU RN Pharmacological characterization of small-conductance Ca(2+)-activated K(+) channels stably expressed in HEK 293 cells. Br J Pharmacol. 2000 Mar;129(5):991-9. DMZNJFU RU https://pubmed.ncbi.nlm.nih.gov/10696100 DMZNJFU DI DMZNJFU DMZNJFU DN UCL1684 DMZNJFU MI TT9JH25 DMZNJFU MN Calcium-activated potassium channel KCa2.3 (KCNN3) DMZNJFU MT DTT DMZNJFU MA Blocker (channel blocker) DMZNJFU RN SK3 is an important component of K(+) channels mediating the afterhyperpolarization in cultured rat SCG neurones. J Physiol. 2001 Sep 1;535(Pt 2):323-34. DMZNJFU RU https://pubmed.ncbi.nlm.nih.gov/11533126 DM2CN0A DI DM2CN0A DM2CN0A DN UCL1848 DM2CN0A MI TT9R6BE DM2CN0A MN Calcium-activated potassium channel KCa2.1 (KCNN1) DM2CN0A MT DTT DM2CN0A MA Blocker (channel blocker) DM2CN0A RN The pharmacology of hSK1 Ca2+-activated K+ channels expressed in mammalian cell lines. Br J Pharmacol. 2000 Feb;129(4):627-30. DM2CN0A RU https://pubmed.ncbi.nlm.nih.gov/10683185 DM2CN0A DI DM2CN0A DM2CN0A DN UCL1848 DM2CN0A MI TT2T5M0 DM2CN0A MN Calcium-activated potassium channel KCa2.2 (KCNN2) DM2CN0A MT DTT DM2CN0A MA Blocker (channel blocker) DM2CN0A RN Calcium-activated potassium channels sustain calcium signaling in T lymphocytes. Selective blockers and manipulated channel expression levels. J Biol Chem. 2001 Apr 13;276(15):12249-56. DM2CN0A RU https://pubmed.ncbi.nlm.nih.gov/11278890 DM2CN0A DI DM2CN0A DM2CN0A DN UCL1848 DM2CN0A MI TT9JH25 DM2CN0A MN Calcium-activated potassium channel KCa2.3 (KCNN3) DM2CN0A MT DTT DM2CN0A MA Blocker (channel blocker) DM2CN0A RN SK3 is an important component of K(+) channels mediating the afterhyperpolarization in cultured rat SCG neurones. J Physiol. 2001 Sep 1;535(Pt 2):323-34. DM2CN0A RU https://pubmed.ncbi.nlm.nih.gov/11533126 DM0P5Z9 DI DM0P5Z9 DM0P5Z9 DN UCL1972 DM0P5Z9 MI TT9JNIC DM0P5Z9 MN Histamine H3 receptor (H3R) DM0P5Z9 MT DTT DM0P5Z9 MA Antagonist DM0P5Z9 RN The histamine H3 receptor: from gene cloning to H3 receptor drugs. Nat Rev Drug Discov. 2005 Feb;4(2):107-20. DM0P5Z9 RU https://pubmed.ncbi.nlm.nih.gov/15665857 DM15CJZ DI DM15CJZ DM15CJZ DN UCL-2138 DM15CJZ MI TT9JNIC DM15CJZ MN Histamine H3 receptor (H3R) DM15CJZ MT DTT DM15CJZ MA Inhibitor DM15CJZ RN Fluorinated non-imidazole histamine H3 receptor antagonists. Bioorg Med Chem Lett. 2009 Apr 15;19(8):2172-5. DM15CJZ RU https://pubmed.ncbi.nlm.nih.gov/19286376 DMFYUMX DI DMFYUMX DMFYUMX DN UCL-67022 DMFYUMX MI TT5ZKDI DMFYUMX MN Histone deacetylase 6 (HDAC6) DMFYUMX MT DTT DMFYUMX MA Inhibitor DMFYUMX RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2618). DMFYUMX RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2618 DM9JG1L DI DM9JG1L DM9JG1L DN UCM 549 DM9JG1L MI TT0WAIE DM9JG1L MN Melatonin receptor type 1A (MTNR1A) DM9JG1L MT DTT DM9JG1L MA Antagonist DM9JG1L RN Synthesis, enantiomeric resolution, and structure-activity relationship study of a series of 10,11-dihydro-5H-dibenzo[a,d]cycloheptene MT2 receptor antagonists. ChemMedChem. 2007 Dec;2(12):1741-9. DM9JG1L RU https://pubmed.ncbi.nlm.nih.gov/17907131 DMCKSYQ DI DMCKSYQ DMCKSYQ DN UCM 724 DMCKSYQ MI TT0WAIE DMCKSYQ MN Melatonin receptor type 1A (MTNR1A) DMCKSYQ MT DTT DMCKSYQ MA Antagonist DMCKSYQ RN Synthesis, enantiomeric resolution, and structure-activity relationship study of a series of 10,11-dihydro-5H-dibenzo[a,d]cycloheptene MT2 receptor antagonists. ChemMedChem. 2007 Dec;2(12):1741-9. DMCKSYQ RU https://pubmed.ncbi.nlm.nih.gov/17907131 DMD16MH DI DMD16MH DMD16MH DN UCM 765 DMD16MH MI TT0WAIE DMD16MH MN Melatonin receptor type 1A (MTNR1A) DMD16MH MT DTT DMD16MH MA Agonist DMD16MH RN N-(substituted-anilinoethyl)amides: design, synthesis, and pharmacological characterization of a new class of melatonin receptor ligands. J Med Chem. 2007 Dec 27;50(26):6618-26. DMD16MH RU https://pubmed.ncbi.nlm.nih.gov/18052314 DM8J41W DI DM8J41W DM8J41W DN UCM 793 DM8J41W MI TT0WAIE DM8J41W MN Melatonin receptor type 1A (MTNR1A) DM8J41W MT DTT DM8J41W MA Agonist DM8J41W RN N-(substituted-anilinoethyl)amides: design, synthesis, and pharmacological characterization of a new class of melatonin receptor ligands. J Med Chem. 2007 Dec 27;50(26):6618-26. DM8J41W RU https://pubmed.ncbi.nlm.nih.gov/18052314 DMSVJFG DI DMSVJFG DMSVJFG DN UCM-454 DMSVJFG MI TT0WAIE DMSVJFG MN Melatonin receptor type 1A (MTNR1A) DMSVJFG MT DTT DMSVJFG MA Inhibitor DMSVJFG RN 2-[(2,3-dihydro-1H-indol-1-yl)methyl]melatonin analogues: a novel class of MT2-selective melatonin receptor antagonists. J Med Chem. 2009 Feb 12;52(3):826-33. DMSVJFG RU https://pubmed.ncbi.nlm.nih.gov/19193160 DMSVJFG DI DMSVJFG DMSVJFG DN UCM-454 DMSVJFG MI TT32JK8 DMSVJFG MN Melatonin receptor type 1B (MTNR1B) DMSVJFG MT DTT DMSVJFG MA Inhibitor DMSVJFG RN 2-[(2,3-dihydro-1H-indol-1-yl)methyl]melatonin analogues: a novel class of MT2-selective melatonin receptor antagonists. J Med Chem. 2009 Feb 12;52(3):826-33. DMSVJFG RU https://pubmed.ncbi.nlm.nih.gov/19193160 DMOJ4TG DI DMOJ4TG DMOJ4TG DN UCM-5600 DMOJ4TG MI TTO9X1H DMOJ4TG MN 5-HT 7 receptor (HTR7) DMOJ4TG MT DTT DMOJ4TG MA Inhibitor DMOJ4TG RN Synthesis of new serotonin 5-HT7 receptor ligands. Determinants of 5-HT7/5-HT1A receptor selectivity. J Med Chem. 2009 Apr 23;52(8):2384-92. DMOJ4TG RU https://pubmed.ncbi.nlm.nih.gov/19326916 DMTQEDA DI DMTQEDA DMTQEDA DN UCPH-101 DMTQEDA MI TT8WRDA DMTQEDA MN Excitatory amino acid transporter 1 (SLC1A3) DMTQEDA MT DTT DMTQEDA MA Inhibitor DMTQEDA RN Discovery of the first selective inhibitor of excitatory amino acid transporter subtype 1. J Med Chem. 2009 Feb 26;52(4):912-5. DMTQEDA RU https://pubmed.ncbi.nlm.nih.gov/19161278 DMMWHAV DI DMMWHAV DMMWHAV DN UDP-beta-S DMMWHAV MI TTNVSKA DMMWHAV MN P2Y purinoceptor 6 (P2RY6) DMMWHAV MT DTT DMMWHAV MA Agonist DMMWHAV RN P2 receptors activated by uracil nucleotides--an update. Curr Med Chem. 2006;13(3):289-312. DMMWHAV RU https://pubmed.ncbi.nlm.nih.gov/16475938 DMLT4JA DI DMLT4JA DMLT4JA DN UDP-glucose DMLT4JA MI TT72OKI DMLT4JA MN P2Y purinoceptor 14 (P2RY14) DMLT4JA MT DTT DMLT4JA MA Agonist DMLT4JA RN Cloning, pharmacology, and tissue distribution of G-protein-coupled receptor GPR105 (KIAA0001) rodent orthologs. Genomics. 2001 Dec;78(3):124-8. DMLT4JA RU https://pubmed.ncbi.nlm.nih.gov/11735218 DMLT4JA DI DMLT4JA DMLT4JA DN UDP-glucose DMLT4JA MI TTGRHIB DMLT4JA MN UDP-glucose 4-epimerase (GALE) DMLT4JA MT DTT DMLT4JA MA Inhibitor DMLT4JA RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMLT4JA RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMLT4JA DI DMLT4JA DMLT4JA DN UDP-glucose DMLT4JA MI DE48Q2Z DMLT4JA MN UDP-glucose 6-dehydrogenase (UGDH) DMLT4JA MT DME DMLT4JA MA Metabolism DMLT4JA RN Importance of Gly-13 for the coenzyme binding of human UDP-glucose dehydrogenase. J Biol Chem. 2004 Sep 3;279(36):37491-8. DMLT4JA RU https://www.ncbi.nlm.nih.gov/pubmed/?term=15247292 DMLT4JA DI DMLT4JA DMLT4JA DN UDP-glucose DMLT4JA MI DTOUNZE DMLT4JA MN UDP-N-acetylglucosamine/UDP-glucose/GDP-mannose transporter (SLC35D2) DMLT4JA MT DTP DMLT4JA MA Substrate DMLT4JA RN Identification and characterization of human Golgi nucleotide sugar transporter SLC35D2, a novel member of the SLC35 nucleotide sugar transporter family. Genomics. 2005 Jan;85(1):106-16. DMLT4JA RU http://www.ncbi.nlm.nih.gov/pubmed/15607426 DMLT4JA DI DMLT4JA DMLT4JA DN UDP-glucose DMLT4JA MI TTMPART DMLT4JA MN Uracil nucleotide/cysteinyl leukotriene receptor (GPR17) DMLT4JA MT DTT DMLT4JA MA Agonist DMLT4JA RN The orphan receptor GPR17 identified as a new dual uracil nucleotides/cysteinyl-leukotrienes receptor. EMBO J. 2006 Oct 4;25(19):4615-27. DMLT4JA RU https://pubmed.ncbi.nlm.nih.gov/16990797 DMW16X2 DI DMW16X2 DMW16X2 DN UDP-glucuronic acid DMW16X2 MI DEBH7ND DMW16X2 MN Chondroitin sulfate glucuronyltransferase (CHPF2) DMW16X2 MT DME DMW16X2 MA Metabolism DMW16X2 RN Molecular cloning and characterization of a novel chondroitin sulfate glucuronyltransferase that transfers glucuronic acid to N-acetylgalactosamine. J Biol Chem. 2002 Oct 11;277(41):38179-88. DMW16X2 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=12145278 DMW16X2 DI DMW16X2 DMW16X2 DN UDP-glucuronic acid DMW16X2 MI TT72OKI DMW16X2 MN P2Y purinoceptor 14 (P2RY14) DMW16X2 MT DTT DMW16X2 MA Agonist DMW16X2 RN Gi-dependent cell signaling responses of the human P2Y14 receptor in model cell systems. J Pharmacol Exp Ther. 2009 Jul;330(1):162-8. DMW16X2 RU https://pubmed.ncbi.nlm.nih.gov/19339661 DMW16X2 DI DMW16X2 DMW16X2 DN UDP-glucuronic acid DMW16X2 MI DELOY3P DMW16X2 MN UDP-glucuronosyltransferase 1A4 (UGT1A4) DMW16X2 MT DME DMW16X2 MA Metabolism DMW16X2 RN Identification of aspartic acid and histidine residues mediating the reaction mechanism and the substrate specificity of the human UDP-glucuronosyltransferases 1A. J Biol Chem. 2007 Dec 14;282(50):36514-24. DMW16X2 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=17956868 DMW16X2 DI DMW16X2 DMW16X2 DN UDP-glucuronic acid DMW16X2 MI DESD26P DMW16X2 MN UDP-glucuronosyltransferase 1A6 (UGT1A6) DMW16X2 MT DME DMW16X2 MA Metabolism DMW16X2 RN Identification of aspartic acid and histidine residues mediating the reaction mechanism and the substrate specificity of the human UDP-glucuronosyltransferases 1A. J Biol Chem. 2007 Dec 14;282(50):36514-24. DMW16X2 RU https://www.ncbi.nlm.nih.gov/pubmed/?term=17956868 DMVE7MZ DI DMVE7MZ DMVE7MZ DN UDP-xylose DMVE7MZ MI DTMALXP DMVE7MZ MN UDP-xylose and UDP-N-acetylglucosamine transporter (SLC35B4) DMVE7MZ MT DTP DMVE7MZ MA Substrate DMVE7MZ RN The human solute carrier gene SLC35B4 encodes a bifunctional nucleotide sugar transporter with specificity for UDP-xylose and UDP-N-acetylglucosamine. J Biol Chem. 2005 Jul 22;280(29):27230-5. DMVE7MZ RU http://www.ncbi.nlm.nih.gov/pubmed/15911612 DMKZF01 DI DMKZF01 DMKZF01 DN UFP-101 DMKZF01 MI TTNT7K8 DMKZF01 MN Nociceptin receptor (OPRL1) DMKZF01 MT DTT DMKZF01 MA Antagonist DMKZF01 RN Nphe1,Arg14,Lys15nociceptin-NH2, a novel potent and selective antagonist of the nociceptin/orphanin FQ receptor. Br J Pharmacol. 2002 May;136(2):303-11. DMKZF01 RU https://pubmed.ncbi.nlm.nih.gov/12010780 DMENTMP DI DMENTMP DMENTMP DN UFP-112 DMENTMP MI TTNT7K8 DMENTMP MN Nociceptin receptor (OPRL1) DMENTMP MT DTT DMENTMP MA Agonist DMENTMP RN Pharmacological profile of NOP receptors coupled with calcium signaling via the chimeric protein G alpha qi5. Naunyn Schmiedebergs Arch Pharmacol. 2009 Jun;379(6):599-607. DMENTMP RU https://pubmed.ncbi.nlm.nih.gov/19183962 DMD8BRG DI DMD8BRG DMD8BRG DN UFP-502 DMD8BRG MI TT27RFC DMD8BRG MN Opioid receptor delta (OPRD1) DMD8BRG MT DTT DMD8BRG MA Inhibitor DMD8BRG RN Role of 2',6'-dimethyl-l-tyrosine (Dmt) in some opioid lead compounds. Bioorg Med Chem. 2010 Aug 15;18(16):6024-30. DMD8BRG RU https://pubmed.ncbi.nlm.nih.gov/20637637 DMD8BRG DI DMD8BRG DMD8BRG DN UFP-502 DMD8BRG MI TTKWM86 DMD8BRG MN Opioid receptor mu (MOP) DMD8BRG MT DTT DMD8BRG MA Inhibitor DMD8BRG RN Role of 2',6'-dimethyl-l-tyrosine (Dmt) in some opioid lead compounds. Bioorg Med Chem. 2010 Aug 15;18(16):6024-30. DMD8BRG RU https://pubmed.ncbi.nlm.nih.gov/20637637 DMYPVSJ DI DMYPVSJ DMYPVSJ DN UFP-512 DMYPVSJ MI TT27RFC DMYPVSJ MN Opioid receptor delta (OPRD1) DMYPVSJ MT DTT DMYPVSJ MA Inhibitor DMYPVSJ RN Role of 2',6'-dimethyl-l-tyrosine (Dmt) in some opioid lead compounds. Bioorg Med Chem. 2010 Aug 15;18(16):6024-30. DMYPVSJ RU https://pubmed.ncbi.nlm.nih.gov/20637637 DMYPVSJ DI DMYPVSJ DMYPVSJ DN UFP-512 DMYPVSJ MI TTKWM86 DMYPVSJ MN Opioid receptor mu (MOP) DMYPVSJ MT DTT DMYPVSJ MA Inhibitor DMYPVSJ RN Role of 2',6'-dimethyl-l-tyrosine (Dmt) in some opioid lead compounds. Bioorg Med Chem. 2010 Aug 15;18(16):6024-30. DMYPVSJ RU https://pubmed.ncbi.nlm.nih.gov/20637637 DM5K6ZE DI DM5K6ZE DM5K6ZE DN UH-232 DM5K6ZE MI TTSQIFT DM5K6ZE MN 5-HT 1A receptor (HTR1A) DM5K6ZE MT DTT DM5K6ZE MA Inhibitor DM5K6ZE RN (Dipropylamino)-tetrahydronaphthofurans: centrally acting serotonin agonists and dopamine agonists-antagonists, Bioorg. Med. Chem. Lett. 7(21):2759-2764 (1997). DM5K6ZE RU http://www.sciencedirect.com/science/article/pii/S0960894X97100683 DM5K6ZE DI DM5K6ZE DM5K6ZE DN UH-232 DM5K6ZE MI TTEX248 DM5K6ZE MN Dopamine D2 receptor (D2R) DM5K6ZE MT DTT DM5K6ZE MA Inhibitor DM5K6ZE RN (Dipropylamino)-tetrahydronaphthofurans: centrally acting serotonin agonists and dopamine agonists-antagonists, Bioorg. Med. Chem. Lett. 7(21):2759-2764 (1997). DM5K6ZE RU http://www.sciencedirect.com/science/article/pii/S0960894X97100683 DM5K6ZE DI DM5K6ZE DM5K6ZE DN UH-232 DM5K6ZE MI TT4C8EA DM5K6ZE MN Dopamine D3 receptor (D3R) DM5K6ZE MT DTT DM5K6ZE MA Inhibitor DM5K6ZE RN (Dipropylamino)-tetrahydronaphthofurans: centrally acting serotonin agonists and dopamine agonists-antagonists, Bioorg. Med. Chem. Lett. 7(21):2759-2764 (1997). DM5K6ZE RU http://www.sciencedirect.com/science/article/pii/S0960894X97100683 DM5K6ZE DI DM5K6ZE DM5K6ZE DN UH-232 DM5K6ZE MI TTE0A2F DM5K6ZE MN Dopamine D4 receptor (D4R) DM5K6ZE MT DTT DM5K6ZE MA Inhibitor DM5K6ZE RN (Dipropylamino)-tetrahydronaphthofurans: centrally acting serotonin agonists and dopamine agonists-antagonists, Bioorg. Med. Chem. Lett. 7(21):2759-2764 (1997). DM5K6ZE RU http://www.sciencedirect.com/science/article/pii/S0960894X97100683 DM5NYWV DI DM5NYWV DM5NYWV DN UH-301 DM5NYWV MI TTSQIFT DM5NYWV MN 5-HT 1A receptor (HTR1A) DM5NYWV MT DTT DM5NYWV MA Inhibitor DM5NYWV RN N-[2-[(substituted chroman-8-yl)oxy]ethyl]-4-(4-methoxyphenyl)butylamines: synthesis and wide range of antagonism at the human 5-HT1A receptor. J Med Chem. 1997 Apr 11;40(8):1252-7. DM5NYWV RU https://pubmed.ncbi.nlm.nih.gov/9111299 DM5NYWV DI DM5NYWV DM5NYWV DN UH-301 DM5NYWV MI TTNGILX DM5NYWV MN Adrenergic receptor alpha-1A (ADRA1A) DM5NYWV MT DTT DM5NYWV MA Inhibitor DM5NYWV RN N-[2-[(substituted chroman-8-yl)oxy]ethyl]-4-(4-methoxyphenyl)butylamines: synthesis and wide range of antagonism at the human 5-HT1A receptor. J Med Chem. 1997 Apr 11;40(8):1252-7. DM5NYWV RU https://pubmed.ncbi.nlm.nih.gov/9111299 DM5NYWV DI DM5NYWV DM5NYWV DN UH-301 DM5NYWV MI TTBRKXS DM5NYWV MN Adrenergic receptor alpha-1B (ADRA1B) DM5NYWV MT DTT DM5NYWV MA Inhibitor DM5NYWV RN N-[2-[(substituted chroman-8-yl)oxy]ethyl]-4-(4-methoxyphenyl)butylamines: synthesis and wide range of antagonism at the human 5-HT1A receptor. J Med Chem. 1997 Apr 11;40(8):1252-7. DM5NYWV RU https://pubmed.ncbi.nlm.nih.gov/9111299 DM5NYWV DI DM5NYWV DM5NYWV DN UH-301 DM5NYWV MI TT34BHT DM5NYWV MN Adrenergic receptor alpha-1D (ADRA1D) DM5NYWV MT DTT DM5NYWV MA Inhibitor DM5NYWV RN N-[2-[(substituted chroman-8-yl)oxy]ethyl]-4-(4-methoxyphenyl)butylamines: synthesis and wide range of antagonism at the human 5-HT1A receptor. J Med Chem. 1997 Apr 11;40(8):1252-7. DM5NYWV RU https://pubmed.ncbi.nlm.nih.gov/9111299 DM5NYWV DI DM5NYWV DM5NYWV DN UH-301 DM5NYWV MI TTEX248 DM5NYWV MN Dopamine D2 receptor (D2R) DM5NYWV MT DTT DM5NYWV MA Inhibitor DM5NYWV RN N-[2-[(substituted chroman-8-yl)oxy]ethyl]-4-(4-methoxyphenyl)butylamines: synthesis and wide range of antagonism at the human 5-HT1A receptor. J Med Chem. 1997 Apr 11;40(8):1252-7. DM5NYWV RU https://pubmed.ncbi.nlm.nih.gov/9111299 DMT5UMG DI DMT5UMG DMT5UMG DN UH-AH 37 DMT5UMG MI TTOXS3C DMT5UMG MN Muscarinic acetylcholine receptor (CHRM) DMT5UMG MT DTT DMT5UMG MA Antagonist DMT5UMG RN Comparison of the in vitro and in vivo profiles of tolterodine with those of subtype-selective muscarinic receptor antagonists. Eur J Pharmacol. 1998 May 22;349(2-3):285-92. DMT5UMG RU https://pubmed.ncbi.nlm.nih.gov/9671109 DMT5UMG DI DMT5UMG DMT5UMG DN UH-AH 37 DMT5UMG MI TTQ13Z5 DMT5UMG MN Muscarinic acetylcholine receptor M3 (CHRM3) DMT5UMG MT DTT DMT5UMG MA Antagonist DMT5UMG RN Comparison of the in vitro and in vivo profiles of tolterodine with those of subtype-selective muscarinic receptor antagonists. Eur J Pharmacol. 1998 May 22;349(2-3):285-92. DMT5UMG RU https://pubmed.ncbi.nlm.nih.gov/9671109 DMOVY6L DI DMOVY6L DMOVY6L DN Uinagolide DMOVY6L MI TTEX248 DMOVY6L MN Dopamine D2 receptor (D2R) DMOVY6L MT DTT DMOVY6L MA Agonist DMOVY6L RN Effect of dopamine receptor agonists on sensory nerve activity: possible therapeutic targets for the treatment of asthma and COPD. Br J Pharmacol. 2002 Jun;136(4):620-8. DMOVY6L RU https://pubmed.ncbi.nlm.nih.gov/12055141 DM6GLSF DI DM6GLSF DM6GLSF DN UK-129485 DM6GLSF MI TT84ETX DM6GLSF MN Human immunodeficiency virus Reverse transcriptase (HIV RT) DM6GLSF MT DTT DM6GLSF MA Inhibitor DM6GLSF RN Imidazo[2 3 :6,5]dipyrido[3,2-b:2 3 e]-1,4-diazepines: non-nucleoside HIV-1 reverse transcriptase inhibitors with greater enzyme affinity than nevirapine, Bioorg. Med. Chem. Lett. 2(12):1745-1750(1992). DM6GLSF RU http://www.sciencedirect.com/science/article/pii/S0960894X00804680 DM02FGH DI DM02FGH DM02FGH DN UK-356618 DM02FGH MI TTHY57M DM02FGH MN Matrix metalloproteinase-13 (MMP-13) DM02FGH MT DTT DM02FGH MA Inhibitor DM02FGH RN A potent, selective inhibitor of matrix metalloproteinase-3 for the topical treatment of chronic dermal ulcers. J Med Chem. 2003 Jul 31;46(16):3514-25. DM02FGH RU https://pubmed.ncbi.nlm.nih.gov/12877590 DM02FGH DI DM02FGH DM02FGH DN UK-356618 DM02FGH MI TTJ4QE7 DM02FGH MN Matrix metalloproteinase-14 (MMP-14) DM02FGH MT DTT DM02FGH MA Inhibitor DM02FGH RN A potent, selective inhibitor of matrix metalloproteinase-3 for the topical treatment of chronic dermal ulcers. J Med Chem. 2003 Jul 31;46(16):3514-25. DM02FGH RU https://pubmed.ncbi.nlm.nih.gov/12877590 DM02FGH DI DM02FGH DM02FGH DN UK-356618 DM02FGH MI TTLM12X DM02FGH MN Matrix metalloproteinase-2 (MMP-2) DM02FGH MT DTT DM02FGH MA Inhibitor DM02FGH RN A potent, selective inhibitor of matrix metalloproteinase-3 for the topical treatment of chronic dermal ulcers. J Med Chem. 2003 Jul 31;46(16):3514-25. DM02FGH RU https://pubmed.ncbi.nlm.nih.gov/12877590 DM02FGH DI DM02FGH DM02FGH DN UK-356618 DM02FGH MI TTUZ2L5 DM02FGH MN Matrix metalloproteinase-3 (MMP-3) DM02FGH MT DTT DM02FGH MA Inhibitor DM02FGH RN A potent, selective inhibitor of matrix metalloproteinase-3 for the topical treatment of chronic dermal ulcers. J Med Chem. 2003 Jul 31;46(16):3514-25. DM02FGH RU https://pubmed.ncbi.nlm.nih.gov/12877590 DM02FGH DI DM02FGH DM02FGH DN UK-356618 DM02FGH MI TT6X50U DM02FGH MN Matrix metalloproteinase-9 (MMP-9) DM02FGH MT DTT DM02FGH MA Inhibitor DM02FGH RN A potent, selective inhibitor of matrix metalloproteinase-3 for the topical treatment of chronic dermal ulcers. J Med Chem. 2003 Jul 31;46(16):3514-25. DM02FGH RU https://pubmed.ncbi.nlm.nih.gov/12877590 DME7VG6 DI DME7VG6 DME7VG6 DN UK-383367 DME7VG6 MI TT0L58T DME7VG6 MN Bone morphogenetic protein 1 (BMP1) DME7VG6 MT DTT DME7VG6 MA Inhibitor DME7VG6 RN Succinyl hydroxamates as potent and selective non-peptidic inhibitors of procollagen C-proteinase: design, synthesis, and evaluation as topically a... Bioorg Med Chem Lett. 2008 Dec 15;18(24):6562-7. DME7VG6 RU https://pubmed.ncbi.nlm.nih.gov/18945617 DMXSTF2 DI DMXSTF2 DMXSTF2 DN UNC0006 DMXSTF2 MI TTEX248 DMXSTF2 MN Dopamine D2 receptor (D2R) DMXSTF2 MT DTT DMXSTF2 MA Agonist DMXSTF2 RN Discovery of beta-arrestin-biased dopamine D2 ligands for probing signal transduction pathways essential for antipsychotic efficacy. Proc Natl Acad Sci U S A. 2011 Nov 8;108(45):18488-93. DMXSTF2 RU https://pubmed.ncbi.nlm.nih.gov/22025698 DMCVU1T DI DMCVU1T DMCVU1T DN UNC0321 DMCVU1T MI TTS6RZT DMCVU1T MN Histone-lysine N-methyltransferase EHMT2 (EHMT2) DMCVU1T MT DTT DMCVU1T MA Inhibitor DMCVU1T RN Protein lysine methyltransferase G9a inhibitors: design, synthesis, and structure activity relationships of 2,4-diamino-7-aminoalkoxy-quinazolines. J Med Chem. 2010 Aug 12;53(15):5844-57. DMCVU1T RU https://pubmed.ncbi.nlm.nih.gov/20614940 DM4A1KJ DI DM4A1KJ DM4A1KJ DN UNC0638 DM4A1KJ MI TTOFXD7 DM4A1KJ MN Euchromatic histone-lysine N-methyltransferase 1 (EHMT1) DM4A1KJ MT DTT DM4A1KJ MA Inhibitor DM4A1KJ RN A chemical probe selectively inhibits G9a and GLP methyltransferase activity in cells. Nat Chem Biol. 2011 Jul 10;7(8):566-74. DM4A1KJ RU https://pubmed.ncbi.nlm.nih.gov/21743462 DM4A1KJ DI DM4A1KJ DM4A1KJ DN UNC0638 DM4A1KJ MI TTS6RZT DM4A1KJ MN Histone-lysine N-methyltransferase EHMT2 (EHMT2) DM4A1KJ MT DTT DM4A1KJ MA Inhibitor DM4A1KJ RN A chemical probe selectively inhibits G9a and GLP methyltransferase activity in cells. Nat Chem Biol. 2011 Jul 10;7(8):566-74. DM4A1KJ RU https://pubmed.ncbi.nlm.nih.gov/21743462 DM7Y1SO DI DM7Y1SO DM7Y1SO DN UNC0642 DM7Y1SO MI TTOFXD7 DM7Y1SO MN Euchromatic histone-lysine N-methyltransferase 1 (EHMT1) DM7Y1SO MT DTT DM7Y1SO MA Inhibitor DM7Y1SO RN Discovery of an in vivo chemical probe of the lysine methyltransferases G9a and GLP. J Med Chem. 2013 Nov 14;56(21):8931-42. DM7Y1SO RU https://pubmed.ncbi.nlm.nih.gov/24102134 DM7Y1SO DI DM7Y1SO DM7Y1SO DN UNC0642 DM7Y1SO MI TTS6RZT DM7Y1SO MN Histone-lysine N-methyltransferase EHMT2 (EHMT2) DM7Y1SO MT DTT DM7Y1SO MA Inhibitor DM7Y1SO RN Discovery of an in vivo chemical probe of the lysine methyltransferases G9a and GLP. J Med Chem. 2013 Nov 14;56(21):8931-42. DM7Y1SO RU https://pubmed.ncbi.nlm.nih.gov/24102134 DMWMRLS DI DMWMRLS DMWMRLS DN UNC1215 DMWMRLS MI TTQDMJN DMWMRLS MN Lethal(3)malignant brain tumor-like 3 (L3MBTL3) DMWMRLS MT DTT DMWMRLS MA Agonist DMWMRLS RN Discovery of a chemical probe for the L3MBTL3 methyllysine reader domain. Nat Chem Biol. 2013 Mar;9(3):184-91. DMWMRLS RU https://pubmed.ncbi.nlm.nih.gov/23292653 DMOPCBD DI DMOPCBD DMOPCBD DN UNC1999 DMOPCBD MI TT9MZCQ DMOPCBD MN Enhancer of zeste homolog 2 (EZH2) DMOPCBD MT DTT DMOPCBD MA Inhibitor DMOPCBD RN An orally bioavailable chemical probe of the Lysine Methyltransferases EZH2 and EZH1. ACS Chem Biol. 2013;8(6):1324-34. DMOPCBD RU https://pubmed.ncbi.nlm.nih.gov/23614352 DMCU59W DI DMCU59W DMCU59W DN UNC2025 DMCU59W MI TTO7LKR DMCU59W MN Tyrosine-protein kinase Mer (MERTK) DMCU59W MT DTT DMCU59W MA Inhibitor DMCU59W RN MerTK as a therapeutic target in glioblastoma. Neuro Oncol. 2018 Jan 10;20(1):92-102. DMCU59W RU https://pubmed.ncbi.nlm.nih.gov/28605477 DMJL6ZM DI DMJL6ZM DMJL6ZM DN UNC569 DMJL6ZM MI TTO7LKR DMJL6ZM MN Tyrosine-protein kinase Mer (MERTK) DMJL6ZM MT DTT DMJL6ZM MA Inhibitor DMJL6ZM RN UNC569, a novel small-molecule mer inhibitor with efficacy against acute lymphoblastic leukemia in vitro and in vivo. Mol Cancer Ther. 2013 Nov;12(11):2367-77. DMJL6ZM RU https://pubmed.ncbi.nlm.nih.gov/23997116 DM4RDVO DI DM4RDVO DM4RDVO DN UNC9975 DM4RDVO MI TTEX248 DM4RDVO MN Dopamine D2 receptor (D2R) DM4RDVO MT DTT DM4RDVO MA Agonist DM4RDVO RN Discovery of beta-arrestin-biased dopamine D2 ligands for probing signal transduction pathways essential for antipsychotic efficacy. Proc Natl Acad Sci U S A. 2011 Nov 8;108(45):18488-93. DM4RDVO RU https://pubmed.ncbi.nlm.nih.gov/22025698 DMDK86V DI DMDK86V DMDK86V DN UNC9994 DMDK86V MI TTEX248 DMDK86V MN Dopamine D2 receptor (D2R) DMDK86V MT DTT DMDK86V MA Agonist DMDK86V RN Discovery of beta-arrestin-biased dopamine D2 ligands for probing signal transduction pathways essential for antipsychotic efficacy. Proc Natl Acad Sci U S A. 2011 Nov 8;108(45):18488-93. DMDK86V RU https://pubmed.ncbi.nlm.nih.gov/22025698 DMFOIPL DI DMFOIPL DMFOIPL DN undecanoic acid DMFOIPL MI TTG0MQD DMFOIPL MN Inflammation-related GPCR EX33 (GPR84) DMFOIPL MT DTT DMFOIPL MA Agonist DMFOIPL RN Medium-chain fatty acids as ligands for orphan G protein-coupled receptor GPR84. J Biol Chem. 2006 Nov 10;281(45):34457-64. DMFOIPL RU https://pubmed.ncbi.nlm.nih.gov/16966319 DM4AYC2 DI DM4AYC2 DM4AYC2 DN Undecylamine-n,n-dimethyl-n-oxide DM4AYC2 MI TT3PQ2Y DM4AYC2 MN Plasmodium Dihydroorotate dehydrogenase (Malaria DHOdehase) DM4AYC2 MT DTT DM4AYC2 MA Inhibitor DM4AYC2 RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DM4AYC2 RU https://pubmed.ncbi.nlm.nih.gov/10592235 DMD9KEB DI DMD9KEB DMD9KEB DN Undecyl-Phosphinic Acid Butyl Ester DMD9KEB MI TTKYZA9 DMD9KEB MN Gastric triacylglycerol lipase (LIPF) DMD9KEB MT DTT DMD9KEB MA Inhibitor DMD9KEB RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DMD9KEB RU https://pubmed.ncbi.nlm.nih.gov/10592235 DMFH79T DI DMFH79T DMFH79T DN UNIFLORINE B DMFH79T MI TTLPC70 DMFH79T MN Lysosomal alpha-glucosidase (GAA) DMFH79T MT DTT DMFH79T MA Inhibitor DMFH79T RN Total synthesis of (-)-uniflorine A. J Nat Prod. 2009 Nov;72(11):2058-60. DMFH79T RU https://pubmed.ncbi.nlm.nih.gov/19835391 DMKQWSB DI DMKQWSB DMKQWSB DN Up3U DMKQWSB MI TTNVSKA DMKQWSB MN P2Y purinoceptor 6 (P2RY6) DMKQWSB MT DTT DMKQWSB MA Agonist DMKQWSB RN P2 receptors activated by uracil nucleotides--an update. Curr Med Chem. 2006;13(3):289-312. DMKQWSB RU https://pubmed.ncbi.nlm.nih.gov/16475938 DMR46C8 DI DMR46C8 DMR46C8 DN UPA-targeted oncolytic Sendai virus DMR46C8 MI TTGY7WI DMR46C8 MN Urokinase-type plasminogen activator (PLAU) DMR46C8 MT DTT DMR46C8 MA Inhibitor DMR46C8 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2393). DMR46C8 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2393 DMPF1VU DI DMPF1VU DMPF1VU DN UR-10324 DMPF1VU MI TTQL5VC DMPF1VU MN Platelet-activating factor receptor (PTAFR) DMPF1VU MT DTT DMPF1VU MA Modulator DMPF1VU RN Effects of PAF-antagonists in mouse ear oedema induced by several inflammatory agents. Br J Pharmacol. 1991 Dec;104(4):990-4. DMPF1VU RU https://www.ncbi.nlm.nih.gov/pubmed/1810607 DM8G9NY DI DM8G9NY DM8G9NY DN UR-11353 DM8G9NY MI TTQL5VC DM8G9NY MN Platelet-activating factor receptor (PTAFR) DM8G9NY MT DTT DM8G9NY MA Modulator DM8G9NY RN Effects of PAF-antagonists in mouse ear oedema induced by several inflammatory agents. Br J Pharmacol. 1991 Dec;104(4):990-4. DM8G9NY RU https://www.ncbi.nlm.nih.gov/pubmed/1810607 DM2HVUW DI DM2HVUW DM2HVUW DN UR-12510 DM2HVUW MI TTQL5VC DM2HVUW MN Platelet-activating factor receptor (PTAFR) DM2HVUW MT DTT DM2HVUW MA Modulator DM2HVUW RN US patent application no. 6,673,908, Tumor necrosis factor receptor 2. DM2HVUW RU http://www.google.com/patents/US6673908 DMVZQ47 DI DMVZQ47 DMVZQ47 DN UR-12519 DMVZQ47 MI TTQL5VC DMVZQ47 MN Platelet-activating factor receptor (PTAFR) DMVZQ47 MT DTT DMVZQ47 MA Modulator DMVZQ47 RN Evidence for the autocrine induction of capacitation of mammalian spermatozoa.J Biol Chem.2001 Jul 20;276(29):26962-8. DMVZQ47 RU https://www.ncbi.nlm.nih.gov/pubmed/11350972 DM3YE5X DI DM3YE5X DM3YE5X DN UR-60427 DM3YE5X MI TTXJ178 DM3YE5X MN Histamine H4 receptor (H4R) DM3YE5X MT DTT DM3YE5X MA Agonist DM3YE5X RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 265). DM3YE5X RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=265 DMNPO9Q DI DMNPO9Q DMNPO9Q DN Uracil DMNPO9Q MI TTZPS91 DMNPO9Q MN Dihydrothymine dehydrogenase (DPYD) DMNPO9Q MT DTT DMNPO9Q MA Modulator DMNPO9Q RN The ChEMBL database in 2017. Nucleic Acids Res. 2017 Jan 4;45(D1):D945-D954. DMNPO9Q RU https://www.ncbi.nlm.nih.gov/pubmed/27899562 DMA1MKT DI DMA1MKT DMA1MKT DN Uric acid DMA1MKT MI DTI7UX6 DMA1MKT MN Breast cancer resistance protein (ABCG2) DMA1MKT MT DTP DMA1MKT MA Substrate DMA1MKT RN Extra-renal elimination of uric acid via intestinal efflux transporter BCRP/ABCG2. PLoS One. 2012;7(2):e30456. DMA1MKT RU https://doi.org/10.1371/journal.pone.0030456 DMA1MKT DI DMA1MKT DMA1MKT DN Uric acid DMA1MKT MI DTQK5O9 DMA1MKT MN Monocarboxylate transporter 9 (SLC16A9) DMA1MKT MT DTP DMA1MKT MA Substrate DMA1MKT RN Common missense variant of monocarboxylate transporter 9 (MCT9/SLC16A9) gene is associated with renal overload gout, but not with all gout susceptibility. Hum Cell. 2013 Dec;26(4):133-6. DMA1MKT RU http://www.ncbi.nlm.nih.gov/pubmed/23990105 DMA1MKT DI DMA1MKT DMA1MKT DN Uric acid DMA1MKT MI DTQ23VB DMA1MKT MN Organic anion transporter 1 (SLC22A6) DMA1MKT MT DTP DMA1MKT MA Substrate DMA1MKT RN Involvement of uric acid transporters in alteration of serum uric acid level by angiotensin II receptor blockers. Pharm Res. 2008 Mar;25(3):639-46. DMA1MKT RU http://www.ncbi.nlm.nih.gov/pubmed/17674156 DMA1MKT DI DMA1MKT DMA1MKT DN Uric acid DMA1MKT MI DTVP67E DMA1MKT MN Organic anion transporter 3 (SLC22A8) DMA1MKT MT DTP DMA1MKT MA Substrate DMA1MKT RN Involvement of uric acid transporters in alteration of serum uric acid level by angiotensin II receptor blockers. Pharm Res. 2008 Mar;25(3):639-46. DMA1MKT RU http://www.ncbi.nlm.nih.gov/pubmed/17674156 DMA1MKT DI DMA1MKT DMA1MKT DN Uric acid DMA1MKT MI DT06JWZ DMA1MKT MN Organic anion transporter 4 (SLC22A11) DMA1MKT MT DTP DMA1MKT MA Substrate DMA1MKT RN Involvement of uric acid transporters in alteration of serum uric acid level by angiotensin II receptor blockers. Pharm Res. 2008 Mar;25(3):639-46. DMA1MKT RU http://www.ncbi.nlm.nih.gov/pubmed/17674156 DMA1MKT DI DMA1MKT DMA1MKT DN Uric acid DMA1MKT MI DT2WLAD DMA1MKT MN Urate anion exchanger 1 (SLC22A12) DMA1MKT MT DTP DMA1MKT MA Substrate DMA1MKT RN Concentration-dependent mode of interaction of angiotensin II receptor blockers with uric acid transporter. J Pharmacol Exp Ther. 2007 Jan;320(1):211-7. DMA1MKT RU http://www.ncbi.nlm.nih.gov/pubmed/17043154 DMPA0BJ DI DMPA0BJ DMPA0BJ DN Uridine diphosphate galactose DMPA0BJ MI DE8RIZD DMPA0BJ MN Collagen galactosyltransferase (COLGALT2) DMPA0BJ MT DME DMPA0BJ MA Metabolism DMPA0BJ RN Core glycosylation of collagen is initiated by two beta(1-O)galactosyltransferases. Mol Cell Biol. 2009 Feb;29(4):943-52. DMPA0BJ RU https://www.ncbi.nlm.nih.gov/pubmed/?term=19075007 DMPA0BJ DI DMPA0BJ DMPA0BJ DN Uridine diphosphate galactose DMPA0BJ MI DESIA7R DMPA0BJ MN Histo-blood group ABO system transferase (NAGAT) DMPA0BJ MT DME DMPA0BJ MA Metabolism DMPA0BJ RN Structural basis for red cell phenotypic changes in newly identified, naturally occurring subgroup mutants of the human blood group B glycosyltransferase. Transfusion. 2007 May;47(5):864-75. DMPA0BJ RU https://www.ncbi.nlm.nih.gov/pubmed/?term=17465952 DMPA0BJ DI DMPA0BJ DMPA0BJ DN Uridine diphosphate galactose DMPA0BJ MI TTGRHIB DMPA0BJ MN UDP-glucose 4-epimerase (GALE) DMPA0BJ MT DTT DMPA0BJ MA Inhibitor DMPA0BJ RN Crystal structure of beta1,4-galactosyltransferase complex with UDP-Gal reveals an oligosaccharide acceptor binding site. J Mol Biol. 2002 Apr 26;318(2):491-502. DMPA0BJ RU https://pubmed.ncbi.nlm.nih.gov/12051854 DMPA0BJ DI DMPA0BJ DMPA0BJ DN Uridine diphosphate galactose DMPA0BJ MI DEKRS6L DMPA0BJ MN Xylosylprotein 4-beta-galactosyltransferase (XGalT-1) DMPA0BJ MT DME DMPA0BJ MA Metabolism DMPA0BJ RN Probing the acceptor active site organization of the human recombinant beta1,4-galactosyltransferase 7 and design of xyloside-based inhibitors. J Biol Chem. 2015 Mar 20;290(12):7658-70. DMPA0BJ RU https://www.ncbi.nlm.nih.gov/pubmed/?term=25568325 DMDQKJB DI DMDQKJB DMDQKJB DN Uridine-5'-Diphosphate DMDQKJB MI TTGRHIB DMDQKJB MN UDP-glucose 4-epimerase (GALE) DMDQKJB MT DTT DMDQKJB MA Inhibitor DMDQKJB RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMDQKJB RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMAYCQU DI DMAYCQU DMAYCQU DN Uridine-5'-Diphosphate-Mannose DMAYCQU MI TTGRHIB DMAYCQU MN UDP-glucose 4-epimerase (GALE) DMAYCQU MT DTT DMAYCQU MA Inhibitor DMAYCQU RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMAYCQU RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMG1NM7 DI DMG1NM7 DMG1NM7 DN Uridine-5'-Monophosphate DMG1NM7 MI TTU6BFZ DMG1NM7 MN Candida Thymidylate synthase (Candi TMP1) DMG1NM7 MT DTT DMG1NM7 MA Inhibitor DMG1NM7 RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMG1NM7 RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMG1NM7 DI DMG1NM7 DMG1NM7 DN Uridine-5'-Monophosphate DMG1NM7 MI TTV7Y40 DMG1NM7 MN Mycobacterium Orotidine phosphate decarboxylase (MycB pyrF) DMG1NM7 MT DTT DMG1NM7 MA Inhibitor DMG1NM7 RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMG1NM7 RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMXHO6J DI DMXHO6J DMXHO6J DN Uridine-Diphosphate-N-Acetylgalactosamine DMXHO6J MI TTP8UCK DMXHO6J MN Bacterial Glycosyltransferase MurG (Bact murG) DMXHO6J MT DTT DMXHO6J MA Inhibitor DMXHO6J RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMXHO6J RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMXHO6J DI DMXHO6J DMXHO6J DN Uridine-Diphosphate-N-Acetylgalactosamine DMXHO6J MI TTGRHIB DMXHO6J MN UDP-glucose 4-epimerase (GALE) DMXHO6J MT DTT DMXHO6J MA Inhibitor DMXHO6J RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMXHO6J RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMEQSTP DI DMEQSTP DMEQSTP DN Uridine-Diphosphate-N-Acetylglucosamine DMEQSTP MI TTICX3S DMEQSTP MN Bacterial UDP-N-acetylglucosamine carboxyvinyltransferase (Bact murA) DMEQSTP MT DTT DMEQSTP MA Inhibitor DMEQSTP RN DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Nucleic Acids Res. 2011 Jan;39(Database issue):D1035-41. DMEQSTP RU https://pubmed.ncbi.nlm.nih.gov/21059682 DMEQSTP DI DMEQSTP DMEQSTP DN Uridine-Diphosphate-N-Acetylglucosamine DMEQSTP MI TTGRHIB DMEQSTP MN UDP-glucose 4-epimerase (GALE) DMEQSTP MT DTT DMEQSTP MA Inhibitor DMEQSTP RN DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Nucleic Acids Res. 2011 Jan;39(Database issue):D1035-41. DMEQSTP RU https://pubmed.ncbi.nlm.nih.gov/21059682 DMCJXWK DI DMCJXWK DMCJXWK DN URMC-099 DMCJXWK MI TTMO45N DMCJXWK MN Cyclin-dependent kinase-like 2 (CDKL2) DMCJXWK MT DTT DMCJXWK MA Inhibitor DMCJXWK RN Discovery, synthesis, and characterization of an orally bioavailable, brain penetrant inhibitor of mixed lineage kinase 3. J Med Chem. 2013 Oct 24;56(20):8032-48. DMCJXWK RU https://pubmed.ncbi.nlm.nih.gov/24044867 DMCJXWK DI DMCJXWK DMCJXWK DN URMC-099 DMCJXWK MI TTERVQN DMCJXWK MN Death-associated protein kinase 3 (DAPK3) DMCJXWK MT DTT DMCJXWK MA Inhibitor DMCJXWK RN Discovery, synthesis, and characterization of an orally bioavailable, brain penetrant inhibitor of mixed lineage kinase 3. J Med Chem. 2013 Oct 24;56(20):8032-48. DMCJXWK RU https://pubmed.ncbi.nlm.nih.gov/24044867 DMCJXWK DI DMCJXWK DMCJXWK DN URMC-099 DMCJXWK MI TTGJCWZ DMCJXWK MN Fms-like tyrosine kinase 3 (FLT-3) DMCJXWK MT DTT DMCJXWK MA Inhibitor DMCJXWK RN Discovery, synthesis, and characterization of an orally bioavailable, brain penetrant inhibitor of mixed lineage kinase 3. J Med Chem. 2013 Oct 24;56(20):8032-48. DMCJXWK RU https://pubmed.ncbi.nlm.nih.gov/24044867 DMCJXWK DI DMCJXWK DMCJXWK DN URMC-099 DMCJXWK MI TTK0FEA DMCJXWK MN Leucine-rich repeat kinase 2 (LRRK2) DMCJXWK MT DTT DMCJXWK MA Inhibitor DMCJXWK RN Discovery, synthesis, and characterization of an orally bioavailable, brain penetrant inhibitor of mixed lineage kinase 3. J Med Chem. 2013 Oct 24;56(20):8032-48. DMCJXWK RU https://pubmed.ncbi.nlm.nih.gov/24044867 DMCJXWK DI DMCJXWK DMCJXWK DN URMC-099 DMCJXWK MI TTK1N5G DMCJXWK MN MAPK/ERK kinase kinase 2 (MAP3K2) DMCJXWK MT DTT DMCJXWK MA Inhibitor DMCJXWK RN Discovery, synthesis, and characterization of an orally bioavailable, brain penetrant inhibitor of mixed lineage kinase 3. J Med Chem. 2013 Oct 24;56(20):8032-48. DMCJXWK RU https://pubmed.ncbi.nlm.nih.gov/24044867 DMCJXWK DI DMCJXWK DMCJXWK DN URMC-099 DMCJXWK MI TTUNSIX DMCJXWK MN Mixed lineage kinase 1 (MAP3K9) DMCJXWK MT DTT DMCJXWK MA Inhibitor DMCJXWK RN Discovery, synthesis, and characterization of an orally bioavailable, brain penetrant inhibitor of mixed lineage kinase 3. J Med Chem. 2013 Oct 24;56(20):8032-48. DMCJXWK RU https://pubmed.ncbi.nlm.nih.gov/24044867 DMCJXWK DI DMCJXWK DMCJXWK DN URMC-099 DMCJXWK MI TT9FN4J DMCJXWK MN Mixed lineage kinase 2 (MAP3K10) DMCJXWK MT DTT DMCJXWK MA Inhibitor DMCJXWK RN Discovery, synthesis, and characterization of an orally bioavailable, brain penetrant inhibitor of mixed lineage kinase 3. J Med Chem. 2013 Oct 24;56(20):8032-48. DMCJXWK RU https://pubmed.ncbi.nlm.nih.gov/24044867 DMCJXWK DI DMCJXWK DMCJXWK DN URMC-099 DMCJXWK MI TTETX6Q DMCJXWK MN Mixed lineage kinase 3 (MAP3K11) DMCJXWK MT DTT DMCJXWK MA Inhibitor DMCJXWK RN Discovery, synthesis, and characterization of an orally bioavailable, brain penetrant inhibitor of mixed lineage kinase 3. J Med Chem. 2013 Oct 24;56(20):8032-48. DMCJXWK RU https://pubmed.ncbi.nlm.nih.gov/24044867 DMCJXWK DI DMCJXWK DMCJXWK DN URMC-099 DMCJXWK MI TTCZEJ9 DMCJXWK MN SRSF protein kinase 2 (SRPK2) DMCJXWK MT DTT DMCJXWK MA Inhibitor DMCJXWK RN Discovery, synthesis, and characterization of an orally bioavailable, brain penetrant inhibitor of mixed lineage kinase 3. J Med Chem. 2013 Oct 24;56(20):8032-48. DMCJXWK RU https://pubmed.ncbi.nlm.nih.gov/24044867 DMCE3PJ DI DMCE3PJ DMCE3PJ DN urotensin II-related peptide DMCE3PJ MI TTW5UDX DMCE3PJ MN Urotensin II receptor (UTS2R) DMCE3PJ MT DTT DMCE3PJ MA Agonist DMCE3PJ RN Identification of urotensin II-related peptide as the urotensin II-immunoreactive molecule in the rat brain. Biochem Biophys Res Commun. 2003 Oct 24;310(3):860-8. DMCE3PJ RU https://pubmed.ncbi.nlm.nih.gov/14550283 DM2C6GB DI DM2C6GB DM2C6GB DN UR-PG131A DM2C6GB MI TTTIBOJ DM2C6GB MN Histamine H1 receptor (H1R) DM2C6GB MT DTT DM2C6GB MA Agonist DM2C6GB RN Probing ligand-specific histamine H1- and H2-receptor conformations with NG-acylated Imidazolylpropylguanidines. J Pharmacol Exp Ther. 2006 Apr;317(1):139-46. DM2C6GB RU https://pubmed.ncbi.nlm.nih.gov/16394198 DMQCL6Y DI DMQCL6Y DMQCL6Y DN UR-PG146 DMQCL6Y MI TTTIBOJ DMQCL6Y MN Histamine H1 receptor (H1R) DMQCL6Y MT DTT DMQCL6Y MA Agonist DMQCL6Y RN Probing ligand-specific histamine H1- and H2-receptor conformations with NG-acylated Imidazolylpropylguanidines. J Pharmacol Exp Ther. 2006 Apr;317(1):139-46. DMQCL6Y RU https://pubmed.ncbi.nlm.nih.gov/16394198 DMQCL6Y DI DMQCL6Y DMQCL6Y DN UR-PG146 DMQCL6Y MI TTQHJ1K DMQCL6Y MN Histamine H2 receptor (H2R) DMQCL6Y MT DTT DMQCL6Y MA Agonist DMQCL6Y RN Probing ligand-specific histamine H1- and H2-receptor conformations with NG-acylated Imidazolylpropylguanidines. J Pharmacol Exp Ther. 2006 Apr;317(1):139-46. DMQCL6Y RU https://pubmed.ncbi.nlm.nih.gov/16394198 DM3VTLG DI DM3VTLG DM3VTLG DN UR-PG153 DM3VTLG MI TTTIBOJ DM3VTLG MN Histamine H1 receptor (H1R) DM3VTLG MT DTT DM3VTLG MA Agonist DM3VTLG RN Probing ligand-specific histamine H1- and H2-receptor conformations with NG-acylated Imidazolylpropylguanidines. J Pharmacol Exp Ther. 2006 Apr;317(1):139-46. DM3VTLG RU https://pubmed.ncbi.nlm.nih.gov/16394198 DM6SM4N DI DM6SM4N DM6SM4N DN UR-PG55B DM6SM4N MI TTTIBOJ DM6SM4N MN Histamine H1 receptor (H1R) DM6SM4N MT DTT DM6SM4N MA Agonist DM6SM4N RN Probing ligand-specific histamine H1- and H2-receptor conformations with NG-acylated Imidazolylpropylguanidines. J Pharmacol Exp Ther. 2006 Apr;317(1):139-46. DM6SM4N RU https://pubmed.ncbi.nlm.nih.gov/16394198 DMCQ8AL DI DMCQ8AL DMCQ8AL DN USIMINE A DMCQ8AL MI TTELIN2 DMCQ8AL MN PTPN1 messenger RNA (PTPN1 mRNA) DMCQ8AL MT DTT DMCQ8AL MA Inhibitor DMCQ8AL RN Usimines A-C, bioactive usnic acid derivatives from the Antarctic lichen Stereocaulon alpinum. J Nat Prod. 2008 Apr;71(4):710-2. DMCQ8AL RU https://pubmed.ncbi.nlm.nih.gov/18288807 DMGOURX DI DMGOURX DMGOURX DN USNIC ACID DMGOURX MI TTELIN2 DMGOURX MN PTPN1 messenger RNA (PTPN1 mRNA) DMGOURX MT DTT DMGOURX MA Inhibitor DMGOURX RN Usimines A-C, bioactive usnic acid derivatives from the Antarctic lichen Stereocaulon alpinum. J Nat Prod. 2008 Apr;71(4):710-2. DMGOURX RU https://pubmed.ncbi.nlm.nih.gov/18288807 DMZP32O DI DMZP32O DMZP32O DN USTILOXIN A DMZP32O MI TTYFKSZ DMZP32O MN Tubulin beta (TUBB) DMZP32O MT DTT DMZP32O MA Inhibitor DMZP32O RN Total synthesis and biological evaluation of ustiloxin natural products and two analogs. Bioorg Med Chem Lett. 2006 Sep 15;16(18):4804-7. DMZP32O RU https://pubmed.ncbi.nlm.nih.gov/16837194 DMZP32O DI DMZP32O DMZP32O DN USTILOXIN A DMZP32O MI TTJ2PTI DMZP32O MN Tubulin beta-2 chain (TUBB2) DMZP32O MT DTT DMZP32O MA Inhibitor DMZP32O RN Total synthesis and biological evaluation of ustiloxin natural products and two analogs. Bioorg Med Chem Lett. 2006 Sep 15;16(18):4804-7. DMZP32O RU https://pubmed.ncbi.nlm.nih.gov/16837194 DMA8JH7 DI DMA8JH7 DMA8JH7 DN Ustiloxin D DMA8JH7 MI TTYFKSZ DMA8JH7 MN Tubulin beta (TUBB) DMA8JH7 MT DTT DMA8JH7 MA Inhibitor DMA8JH7 RN Total synthesis and biological evaluation of ustiloxin natural products and two analogs. Bioorg Med Chem Lett. 2006 Sep 15;16(18):4804-7. DMA8JH7 RU https://pubmed.ncbi.nlm.nih.gov/16837194 DMA8JH7 DI DMA8JH7 DMA8JH7 DN Ustiloxin D DMA8JH7 MI TTJ2PTI DMA8JH7 MN Tubulin beta-2 chain (TUBB2) DMA8JH7 MT DTT DMA8JH7 MA Inhibitor DMA8JH7 RN Total synthesis and biological evaluation of ustiloxin natural products and two analogs. Bioorg Med Chem Lett. 2006 Sep 15;16(18):4804-7. DMA8JH7 RU https://pubmed.ncbi.nlm.nih.gov/16837194 DMT1LS0 DI DMT1LS0 DMT1LS0 DN Ustiloxin F DMT1LS0 MI TTYFKSZ DMT1LS0 MN Tubulin beta (TUBB) DMT1LS0 MT DTT DMT1LS0 MA Inhibitor DMT1LS0 RN Total synthesis and biological evaluation of ustiloxin natural products and two analogs. Bioorg Med Chem Lett. 2006 Sep 15;16(18):4804-7. DMT1LS0 RU https://pubmed.ncbi.nlm.nih.gov/16837194 DMT1LS0 DI DMT1LS0 DMT1LS0 DN Ustiloxin F DMT1LS0 MI TTJ2PTI DMT1LS0 MN Tubulin beta-2 chain (TUBB2) DMT1LS0 MT DTT DMT1LS0 MA Inhibitor DMT1LS0 RN Total synthesis and biological evaluation of ustiloxin natural products and two analogs. Bioorg Med Chem Lett. 2006 Sep 15;16(18):4804-7. DMT1LS0 RU https://pubmed.ncbi.nlm.nih.gov/16837194 DMKLB4O DI DMKLB4O DMKLB4O DN UTPgammaS DMKLB4O MI TTOZHQC DMKLB4O MN P2Y purinoceptor 2 (P2RY2) DMKLB4O MT DTT DMKLB4O MA Agonist DMKLB4O RN Pharmacological selectivity of the cloned human P2U-purinoceptor: potent activation by diadenosine tetraphosphate. Br J Pharmacol. 1995 Sep;116(1):1619-27. DMKLB4O RU https://pubmed.ncbi.nlm.nih.gov/8564228 DMKLB4O DI DMKLB4O DMKLB4O DN UTPgammaS DMKLB4O MI TT24DGP DMKLB4O MN P2Y purinoceptor 4 (P2RY4) DMKLB4O MT DTT DMKLB4O MA Agonist DMKLB4O RN Enzymatic synthesis of UTP gamma S, a potent hydrolysis resistant agonist of P2U-purinoceptors. Br J Pharmacol. 1996 Jan;117(1):203-9. DMKLB4O RU https://pubmed.ncbi.nlm.nih.gov/8825364 DMAFQE1 DI DMAFQE1 DMAFQE1 DN UVAOL DMAFQE1 MI TTELIN2 DMAFQE1 MN PTPN1 messenger RNA (PTPN1 mRNA) DMAFQE1 MT DTT DMAFQE1 MA Inhibitor DMAFQE1 RN Triterpenoids from the leaves of Diospyros kaki (persimmon) and their inhibitory effects on protein tyrosine phosphatase 1B. J Nat Prod. 2008 Oct;71(10):1775-8. DMAFQE1 RU https://pubmed.ncbi.nlm.nih.gov/18798681 DM95UI1 DI DM95UI1 DM95UI1 DN UVI3003 DM95UI1 MI TT6PEUO DM95UI1 MN Retinoic acid receptor RXR-alpha (RXRA) DM95UI1 MT DTT DM95UI1 MA Antagonist DM95UI1 RN Characterization of the interaction between retinoic acid receptor/retinoid X receptor (RAR/RXR) heterodimers and transcriptional coactivators thro... J Biol Chem. 2005 Jan 14;280(2):1625-33. DM95UI1 RU https://pubmed.ncbi.nlm.nih.gov/15528208 DM0KSFN DI DM0KSFN DM0KSFN DN V-103 DM0KSFN MI TT2NUT5 DM0KSFN MN Adrenergic receptor alpha-2C (ADRA2C) DM0KSFN MT DTT DM0KSFN MA Modulator DM0KSFN RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 27). DM0KSFN RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=27 DMXLHIO DI DMXLHIO DMXLHIO DN V158411 DMXLHIO MI TTTU902 DMXLHIO MN Checkpoint kinase-1 (CHK1) DMXLHIO MT DTT DMXLHIO MA Inhibitor DMXLHIO RN Cell Density Affects the Detection of Chk1 Target Engagement by the Selective Inhibitor V158411. SLAS Discov. 2018 Feb;23(2):144-153. DMXLHIO RU https://pubmed.ncbi.nlm.nih.gov/29048945 DM8SWVN DI DM8SWVN DM8SWVN DN V-165 DM8SWVN MI TT5FH9Y DM8SWVN MN Human immunodeficiency virus Integrase (HIV IN) DM8SWVN MT DTT DM8SWVN MA Inhibitor DM8SWVN RN New class of HIV integrase inhibitors that block viral replication in cell culture. Curr Biol. 2002 Jul 23;12(14):1169-77. DM8SWVN RU https://pubmed.ncbi.nlm.nih.gov/12176326 DMH971B DI DMH971B DMH971B DN V1A F/U DMH971B MI TT4TFGN DMH971B MN Vasopressin V1a receptor (V1AR) DMH971B MT DTT DMH971B MA Antagonist DMH971B RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 366). DMH971B RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=366 DM65GQD DI DM65GQD DM65GQD DN VA-118020 DM65GQD MI TT5T3P6 DM65GQD MN Tissue kallikrein (KLK1) DM65GQD MT DTT DM65GQD MA Inhibitor DM65GQD RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2865). DM65GQD RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2865 DMG53XV DI DMG53XV DMG53XV DN VA-119930 DMG53XV MI TTGPQ0F DMG53XV MN Prolyl endopeptidase FAP (FAP) DMG53XV MT DTT DMG53XV MA Inhibitor DMG53XV RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2365). DMG53XV RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2365 DMEOJ89 DI DMEOJ89 DMEOJ89 DN VAGANINE D DMEOJ89 MI TTEB0GD DMEOJ89 MN Cholinesterase (BCHE) DMEOJ89 MT DTT DMEOJ89 MA Inhibitor DMEOJ89 RN Steroidal alkaloids from the leaves of Sarcococca coriacea of Nepalese origin. J Nat Prod. 2001 Jun;64(6):842-4. DMEOJ89 RU https://pubmed.ncbi.nlm.nih.gov/11421762 DMW4TYV DI DMW4TYV DMW4TYV DN Valinomycin DMW4TYV MI DTUGYRD DMW4TYV MN P-glycoprotein 1 (ABCB1) DMW4TYV MT DTP DMW4TYV MA Substrate DMW4TYV RN Modulation of drug-stimulated ATPase activity of human MDR1/P-glycoprotein by cholesterol. Biochem J. 2007 Jan 15;401(2):597-605. DMW4TYV RU http://www.ncbi.nlm.nih.gov/pubmed/17029589 DM2VQN5 DI DM2VQN5 DM2VQN5 DN VALIOLAMINE DM2VQN5 MI TTLPC70 DM2VQN5 MN Lysosomal alpha-glucosidase (GAA) DM2VQN5 MT DTT DM2VQN5 MA Inhibitor DM2VQN5 RN In vitro inhibition of glycogen-degrading enzymes and glycosidases by six-membered sugar mimics and their evaluation in cell cultures. Bioorg Med Chem. 2008 Aug 1;16(15):7330-6. DM2VQN5 RU https://pubmed.ncbi.nlm.nih.gov/18595718 DM30E56 DI DM30E56 DM30E56 DN Vapill DM30E56 MI TT7HC21 DM30E56 MN Membrane copper amine oxidase (AOC3) DM30E56 MT DTT DM30E56 MA Inhibitor DM30E56 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2767). DM30E56 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2767 DMD7M9L DI DMD7M9L DMD7M9L DN VAR-10200 DMD7M9L MI TTGP7BY DMD7M9L MN Monoamine oxidase type B (MAO-B) DMD7M9L MT DTT DMD7M9L MA Modulator DMD7M9L RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2490). DMD7M9L RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2490 DMFKTPO DI DMFKTPO DMFKTPO DN VAR-10300 DMFKTPO MI TTGP7BY DMFKTPO MN Monoamine oxidase type B (MAO-B) DMFKTPO MT DTT DMFKTPO MA Inhibitor DMFKTPO RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2490). DMFKTPO RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2490 DMVBO78 DI DMVBO78 DMVBO78 DN VARIECOLIN DMVBO78 MI TT2CEJG DMVBO78 MN C-C chemokine receptor type 5 (CCR5) DMVBO78 MT DTT DMVBO78 MA Inhibitor DMVBO78 RN Inhibition of the human chemokine receptor CCR5 by variecolin and variecolol and isolation of four new variecolin analogues, emericolins A-D, from ... J Nat Prod. 2004 Oct;67(10):1681-4. DMVBO78 RU https://pubmed.ncbi.nlm.nih.gov/15497939 DM3K8PT DI DM3K8PT DM3K8PT DN Va-RYYRIK-NH2 DM3K8PT MI TTNT7K8 DM3K8PT MN Nociceptin receptor (OPRL1) DM3K8PT MT DTT DM3K8PT MA Inhibitor DM3K8PT RN Designed modification of partial agonist of ORL1 nociceptin receptor for conversion into highly potent antagonist. Bioorg Med Chem. 2008 Mar 1;16(5):2635-44. DM3K8PT RU https://pubmed.ncbi.nlm.nih.gov/18068993 DM8ACIF DI DM8ACIF DM8ACIF DN VBY- 285 DM8ACIF MI TTUMQVO DM8ACIF MN Cathepsin S (CTSS) DM8ACIF MT DTT DM8ACIF MA Inhibitor DM8ACIF RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2353). DM8ACIF RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2353 DMG1YZQ DI DMG1YZQ DMG1YZQ DN VCP-28 DMG1YZQ MI TTK25J1 DMG1YZQ MN Adenosine A1 receptor (ADORA1) DMG1YZQ MT DTT DMG1YZQ MA Inhibitor DMG1YZQ RN Synthesis and evaluation of new N6-substituted adenosine-5'-N-methylcarboxamides as A3 adenosine receptor agonists. Bioorg Med Chem. 2010 May 1;18(9):3078-87. DMG1YZQ RU https://pubmed.ncbi.nlm.nih.gov/20385496 DMN62VE DI DMN62VE DMN62VE DN VDA-1124 DMN62VE MI TTKEPHX DMN62VE MN Granzyme B (GZMB) DMN62VE MT DTT DMN62VE MA Inhibitor DMN62VE RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2369). DMN62VE RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2369 DM3GADP DI DM3GADP DM3GADP DN VE-04051645 DM3GADP MI TT6L509 DM3GADP MN Coagulation factor IIa (F2) DM3GADP MT DTT DM3GADP MA Inhibitor DM3GADP RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2362). DM3GADP RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2362 DM0UXNF DI DM0UXNF DM0UXNF DN VE-821 DM0UXNF MI TT8ZYBQ DM0UXNF MN Serine/threonine-protein kinase ATR (FRP1) DM0UXNF MT DTT DM0UXNF MA Inhibitor DM0UXNF RN ATR inhibitors VE-821 and VX-970 sensitize cancer cells to topoisomerase i inhibitors by disabling DNA replication initiation and fork elongation responses. Cancer Res. 2014 Dec 1;74(23):6968-79. DM0UXNF RU https://pubmed.ncbi.nlm.nih.gov/25269479 DMWXCYA DI DMWXCYA DMWXCYA DN VEGF receptor 2 kinase inhibitor I DMWXCYA MI TTUTJGQ DMWXCYA MN Vascular endothelial growth factor receptor 2 (KDR) DMWXCYA MT DTT DMWXCYA MA Inhibitor DMWXCYA RN Synthesis and biological evaluations of 3-substituted indolin-2-ones: a novel class of tyrosine kinase inhibitors that exhibit selectivity toward particular receptor tyrosine kinases. J Med Chem. 1998 Jul 2;41(14):2588-603. DMWXCYA RU https://pubmed.ncbi.nlm.nih.gov/9651163 DMFZMA2 DI DMFZMA2 DMFZMA2 DN VER-156084 DMFZMA2 MI TT6OEDT DMFZMA2 MN Cannabinoid receptor 1 (CB1) DMFZMA2 MT DTT DMFZMA2 MA Inhibitor DMFZMA2 RN Fatty acid amide hydrolase inhibitors. Surprising selectivity of chiral azetidine ureas. Bioorg Med Chem Lett. 2009 Aug 1;19(15):4241-4. DMFZMA2 RU https://pubmed.ncbi.nlm.nih.gov/19515560 DMFZMA2 DI DMFZMA2 DMFZMA2 DN VER-156084 DMFZMA2 MI TTMSFAW DMFZMA2 MN Cannabinoid receptor 2 (CB2) DMFZMA2 MT DTT DMFZMA2 MA Inhibitor DMFZMA2 RN Fatty acid amide hydrolase inhibitors. Surprising selectivity of chiral azetidine ureas. Bioorg Med Chem Lett. 2009 Aug 1;19(15):4241-4. DMFZMA2 RU https://pubmed.ncbi.nlm.nih.gov/19515560 DMFZMA2 DI DMFZMA2 DMFZMA2 DN VER-156084 DMFZMA2 MI TTDP1UC DMFZMA2 MN Fatty acid amide hydrolase (FAAH) DMFZMA2 MT DTT DMFZMA2 MA Inhibitor DMFZMA2 RN Fatty acid amide hydrolase inhibitors. Surprising selectivity of chiral azetidine ureas. Bioorg Med Chem Lett. 2009 Aug 1;19(15):4241-4. DMFZMA2 RU https://pubmed.ncbi.nlm.nih.gov/19515560 DMCRHOA DI DMCRHOA DMCRHOA DN VER-156085 DMCRHOA MI TT6OEDT DMCRHOA MN Cannabinoid receptor 1 (CB1) DMCRHOA MT DTT DMCRHOA MA Inhibitor DMCRHOA RN Fatty acid amide hydrolase inhibitors. Surprising selectivity of chiral azetidine ureas. Bioorg Med Chem Lett. 2009 Aug 1;19(15):4241-4. DMCRHOA RU https://pubmed.ncbi.nlm.nih.gov/19515560 DMCRHOA DI DMCRHOA DMCRHOA DN VER-156085 DMCRHOA MI TTMSFAW DMCRHOA MN Cannabinoid receptor 2 (CB2) DMCRHOA MT DTT DMCRHOA MA Inhibitor DMCRHOA RN Fatty acid amide hydrolase inhibitors. Surprising selectivity of chiral azetidine ureas. Bioorg Med Chem Lett. 2009 Aug 1;19(15):4241-4. DMCRHOA RU https://pubmed.ncbi.nlm.nih.gov/19515560 DM5WAM8 DI DM5WAM8 DM5WAM8 DN VER-2692 DM5WAM8 MI TTJQOD7 DM5WAM8 MN 5-HT 2A receptor (HTR2A) DM5WAM8 MT DTT DM5WAM8 MA Inhibitor DM5WAM8 RN Pyrrolo(iso)quinoline derivatives as 5-HT(2C) receptor agonists. Bioorg Med Chem Lett. 2006 Feb;16(3):677-80. DM5WAM8 RU https://pubmed.ncbi.nlm.nih.gov/16257207 DM5WAM8 DI DM5WAM8 DM5WAM8 DN VER-2692 DM5WAM8 MI TT0K1SC DM5WAM8 MN 5-HT 2B receptor (HTR2B) DM5WAM8 MT DTT DM5WAM8 MA Inhibitor DM5WAM8 RN Pyrrolo(iso)quinoline derivatives as 5-HT(2C) receptor agonists. Bioorg Med Chem Lett. 2006 Feb;16(3):677-80. DM5WAM8 RU https://pubmed.ncbi.nlm.nih.gov/16257207 DM5WAM8 DI DM5WAM8 DM5WAM8 DN VER-2692 DM5WAM8 MI TTWJBZ5 DM5WAM8 MN 5-HT 2C receptor (HTR2C) DM5WAM8 MT DTT DM5WAM8 MA Inhibitor DM5WAM8 RN Pyrrolo(iso)quinoline derivatives as 5-HT(2C) receptor agonists. Bioorg Med Chem Lett. 2006 Feb;16(3):677-80. DM5WAM8 RU https://pubmed.ncbi.nlm.nih.gov/16257207 DM7O2K1 DI DM7O2K1 DM7O2K1 DN VER-3323 DM7O2K1 MI TTJQOD7 DM7O2K1 MN 5-HT 2A receptor (HTR2A) DM7O2K1 MT DTT DM7O2K1 MA Inhibitor DM7O2K1 RN Indoline derivatives as 5-HT(2C) receptor agonists. Bioorg Med Chem Lett. 2004 May 3;14(9):2367-70. DM7O2K1 RU https://pubmed.ncbi.nlm.nih.gov/15081042 DM7O2K1 DI DM7O2K1 DM7O2K1 DN VER-3323 DM7O2K1 MI TT0K1SC DM7O2K1 MN 5-HT 2B receptor (HTR2B) DM7O2K1 MT DTT DM7O2K1 MA Inhibitor DM7O2K1 RN Indoline derivatives as 5-HT(2C) receptor agonists. Bioorg Med Chem Lett. 2004 May 3;14(9):2367-70. DM7O2K1 RU https://pubmed.ncbi.nlm.nih.gov/15081042 DM7O2K1 DI DM7O2K1 DM7O2K1 DN VER-3323 DM7O2K1 MI TTWJBZ5 DM7O2K1 MN 5-HT 2C receptor (HTR2C) DM7O2K1 MT DTT DM7O2K1 MA Inhibitor DM7O2K1 RN Indoline derivatives as 5-HT(2C) receptor agonists. Bioorg Med Chem Lett. 2004 May 3;14(9):2367-70. DM7O2K1 RU https://pubmed.ncbi.nlm.nih.gov/15081042 DMF1KDX DI DMF1KDX DMF1KDX DN VER-49009 DMF1KDX MI TT78R5H DMF1KDX MN Heat shock protein 90 alpha (HSP90A) DMF1KDX MT DTT DMF1KDX MA Inhibitor DMF1KDX RN Novel, potent small-molecule inhibitors of the molecular chaperone Hsp90 discovered through structure-based design. J Med Chem. 2005 Jun 30;48(13):4212-5. DMF1KDX RU https://pubmed.ncbi.nlm.nih.gov/15974572 DMC2EO9 DI DMC2EO9 DMC2EO9 DN VER-5384 DMC2EO9 MI TTJQOD7 DMC2EO9 MN 5-HT 2A receptor (HTR2A) DMC2EO9 MT DTT DMC2EO9 MA Inhibitor DMC2EO9 RN Indoline derivatives as 5-HT(2C) receptor agonists. Bioorg Med Chem Lett. 2004 May 3;14(9):2367-70. DMC2EO9 RU https://pubmed.ncbi.nlm.nih.gov/15081042 DMC2EO9 DI DMC2EO9 DMC2EO9 DN VER-5384 DMC2EO9 MI TT0K1SC DMC2EO9 MN 5-HT 2B receptor (HTR2B) DMC2EO9 MT DTT DMC2EO9 MA Inhibitor DMC2EO9 RN Indoline derivatives as 5-HT(2C) receptor agonists. Bioorg Med Chem Lett. 2004 May 3;14(9):2367-70. DMC2EO9 RU https://pubmed.ncbi.nlm.nih.gov/15081042 DMC2EO9 DI DMC2EO9 DMC2EO9 DN VER-5384 DMC2EO9 MI TTWJBZ5 DMC2EO9 MN 5-HT 2C receptor (HTR2C) DMC2EO9 MT DTT DMC2EO9 MA Inhibitor DMC2EO9 RN Indoline derivatives as 5-HT(2C) receptor agonists. Bioorg Med Chem Lett. 2004 May 3;14(9):2367-70. DMC2EO9 RU https://pubmed.ncbi.nlm.nih.gov/15081042 DMYD7P5 DI DMYD7P5 DMYD7P5 DN VER-54505 DMYD7P5 MI TT7HF4W DMYD7P5 MN Cyclin-dependent kinase 2 (CDK2) DMYD7P5 MT DTT DMYD7P5 MA Inhibitor DMYD7P5 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1973). DMYD7P5 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1973 DMZ2V0A DI DMZ2V0A DMZ2V0A DN VER-5593 DMZ2V0A MI TTJQOD7 DMZ2V0A MN 5-HT 2A receptor (HTR2A) DMZ2V0A MT DTT DMZ2V0A MA Inhibitor DMZ2V0A RN Indoline derivatives as 5-HT(2C) receptor agonists. Bioorg Med Chem Lett. 2004 May 3;14(9):2367-70. DMZ2V0A RU https://pubmed.ncbi.nlm.nih.gov/15081042 DMZ2V0A DI DMZ2V0A DMZ2V0A DN VER-5593 DMZ2V0A MI TT0K1SC DMZ2V0A MN 5-HT 2B receptor (HTR2B) DMZ2V0A MT DTT DMZ2V0A MA Inhibitor DMZ2V0A RN Indoline derivatives as 5-HT(2C) receptor agonists. Bioorg Med Chem Lett. 2004 May 3;14(9):2367-70. DMZ2V0A RU https://pubmed.ncbi.nlm.nih.gov/15081042 DMZ2V0A DI DMZ2V0A DMZ2V0A DN VER-5593 DMZ2V0A MI TTWJBZ5 DMZ2V0A MN 5-HT 2C receptor (HTR2C) DMZ2V0A MT DTT DMZ2V0A MA Inhibitor DMZ2V0A RN Indoline derivatives as 5-HT(2C) receptor agonists. Bioorg Med Chem Lett. 2004 May 3;14(9):2367-70. DMZ2V0A RU https://pubmed.ncbi.nlm.nih.gov/15081042 DMJRVBS DI DMJRVBS DMJRVBS DN VERAGUENSIN DMJRVBS MI TTQL5VC DMJRVBS MN Platelet-activating factor receptor (PTAFR) DMJRVBS MT DTT DMJRVBS MA Inhibitor DMJRVBS RN Development, synthesis, and biological evaluation of (-)-trans-(2S,5S)-2-[3-[(2-oxopropyl)sulfonyl]-4-n-propoxy-5-(3- hydroxypropoxy)-phenyl]-5-(3,... J Med Chem. 1992 Sep 18;35(19):3474-82. DMJRVBS RU https://pubmed.ncbi.nlm.nih.gov/1404229 DMUF8JZ DI DMUF8JZ DMUF8JZ DN Veratridine DMUF8JZ MI TTANOZH DMUF8JZ MN SCN1A messenger RNA (SCN1A mRNA) DMUF8JZ MT DTT DMUF8JZ MA Activator DMUF8JZ RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 578). DMUF8JZ RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=578 DMUF8JZ DI DMUF8JZ DMUF8JZ DN Veratridine DMUF8JZ MI TTLJTUF DMUF8JZ MN Voltage-gated sodium channel alpha Nav1.2 (SCN2A) DMUF8JZ MT DTT DMUF8JZ MA Activator DMUF8JZ RN Binding of batrachotoxinin A 20-alpha-benzoate to a receptor site associated with sodium channels in synaptic nerve ending particles. J Biol Chem. 1981 Sep 10;256(17):8922-7. DMUF8JZ RU https://pubmed.ncbi.nlm.nih.gov/6114956 DMUF8JZ DI DMUF8JZ DMUF8JZ DN Veratridine DMUF8JZ MI TTAXZ0K DMUF8JZ MN Voltage-gated sodium channel alpha Nav1.3 (SCN3A) DMUF8JZ MT DTT DMUF8JZ MA Activator DMUF8JZ RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 580). DMUF8JZ RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=580 DMUF8JZ DI DMUF8JZ DMUF8JZ DN Veratridine DMUF8JZ MI TT84DRB DMUF8JZ MN Voltage-gated sodium channel alpha Nav1.4 (SCN4A) DMUF8JZ MT DTT DMUF8JZ MA Activator DMUF8JZ RN Point mutations in segment I-S6 render voltage-gated Na+ channels resistant to batrachotoxin. Proc Natl Acad Sci U S A. 1998 Mar 3;95(5):2653-8. DMUF8JZ RU https://pubmed.ncbi.nlm.nih.gov/9482942 DMUF8JZ DI DMUF8JZ DMUF8JZ DN Veratridine DMUF8JZ MI TTZOVE0 DMUF8JZ MN Voltage-gated sodium channel alpha Nav1.5 (SCN5A) DMUF8JZ MT DTT DMUF8JZ MA Activator DMUF8JZ RN Sodium channel comodification with full activator reveals veratridine reaction dynamics. Mol Pharmacol. 1990 Feb;37(2):144-8. DMUF8JZ RU https://pubmed.ncbi.nlm.nih.gov/2154667 DMUF8JZ DI DMUF8JZ DMUF8JZ DN Veratridine DMUF8JZ MI TT54ERL DMUF8JZ MN Voltage-gated sodium channel alpha Nav1.6 (SCN8A) DMUF8JZ MT DTT DMUF8JZ MA Activator DMUF8JZ RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 583). DMUF8JZ RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=583 DMUF8JZ DI DMUF8JZ DMUF8JZ DN Veratridine DMUF8JZ MI TT4G2JS DMUF8JZ MN Voltage-gated sodium channel alpha Nav1.7 (SCN9A) DMUF8JZ MT DTT DMUF8JZ MA Activator DMUF8JZ RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 584). DMUF8JZ RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=584 DMUF8JZ DI DMUF8JZ DMUF8JZ DN Veratridine DMUF8JZ MI TT90XZ8 DMUF8JZ MN Voltage-gated sodium channel alpha Nav1.8 (SCN10A) DMUF8JZ MT DTT DMUF8JZ MA Activator DMUF8JZ RN A comparison of the effects of veratridine on tetrodotoxin-sensitive and tetrodotoxin-resistant sodium channels in isolated rat dorsal root ganglio... Pflugers Arch. 2008 Feb;455(5):929-38. DMUF8JZ RU https://pubmed.ncbi.nlm.nih.gov/17962978 DM7NRK5 DI DM7NRK5 DM7NRK5 DN Verdoheme DM7NRK5 MI TTI6V2A DM7NRK5 MN Heme oxygenase 1 (HMOX1) DM7NRK5 MT DTT DM7NRK5 MA Inhibitor DM7NRK5 RN DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Nucleic Acids Res. 2011 Jan;39(Database issue):D1035-41. DM7NRK5 RU https://pubmed.ncbi.nlm.nih.gov/21059682 DMD1C6S DI DMD1C6S DMD1C6S DN Verongamine DMD1C6S MI TT9JNIC DMD1C6S MN Histamine H3 receptor (H3R) DMD1C6S MT DTT DMD1C6S MA Inhibitor DMD1C6S RN Verongamine, a novel bromotyrosine-derived histamine H3-antagonist from the marine sponge Verongula gigantea. J Nat Prod. 1994 Jan;57(1):175-7. DMD1C6S RU https://pubmed.ncbi.nlm.nih.gov/8158162 DMUHEJ3 DI DMUHEJ3 DMUHEJ3 DN Very low dose (VLD) cyclobenzaprine DMUHEJ3 MI TTJQOD7 DMUHEJ3 MN 5-HT 2A receptor (HTR2A) DMUHEJ3 MT DTT DMUHEJ3 MA Modulator DMUHEJ3 RN Pharmacological profile of the new potent neuroleptic ocaperidone (R 79,598). J Pharmacol Exp Ther. 1992 Jan;260(1):146-59. DMUHEJ3 RU https://pubmed.ncbi.nlm.nih.gov/1370538 DMHKUBG DI DMHKUBG DMHKUBG DN Vesamicol DMHKUBG MI TTV8KWS DMHKUBG MN Vesicular acetylcholine transporter (SLC18A3) DMHKUBG MT DTT DMHKUBG MA Inhibitor DMHKUBG RN Vesamicol analogues as sigma ligands. Molecular determinants of selectivity at the vesamicol receptor. Biochem Pharmacol. 1995 Mar 15;49(6):791-7. DMHKUBG RU https://pubmed.ncbi.nlm.nih.gov/7702637 DMO4GBK DI DMO4GBK DMO4GBK DN vinburnine DMO4GBK MI TTOXS3C DMO4GBK MN Muscarinic acetylcholine receptor (CHRM) DMO4GBK MT DTT DMO4GBK MA Modulator (allosteric modulator) DMO4GBK RN Positive cooperativity of acetylcholine and other agonists with allosteric ligands on muscarinic acetylcholine receptors. Mol Pharmacol. 1997 Jul;52(1):172-9. DMO4GBK RU https://pubmed.ncbi.nlm.nih.gov/9224827 DMO4GBK DI DMO4GBK DMO4GBK DN vinburnine DMO4GBK MI TTQ13Z5 DMO4GBK MN Muscarinic acetylcholine receptor M3 (CHRM3) DMO4GBK MT DTT DMO4GBK MA Modulator (allosteric modulator) DMO4GBK RN Positive cooperativity of acetylcholine and other agonists with allosteric ligands on muscarinic acetylcholine receptors. Mol Pharmacol. 1997 Jul;52(1):172-9. DMO4GBK RU https://pubmed.ncbi.nlm.nih.gov/9224827 DMNFVO7 DI DMNFVO7 DMNFVO7 DN Vinylsulphones DMNFVO7 MI TT7EASG DMNFVO7 MN Plasmodium Cysteine protease falcipain-2 (Malaria CPF2) DMNFVO7 MT DTT DMNFVO7 MA Binder DMNFVO7 RN Opportunities and challenges in antiparasitic drug discovery. Nat Rev Drug Discov. 2005 Sep;4(9):727-40. DMNFVO7 RU https://pubmed.ncbi.nlm.nih.gov/16138106 DMNFVO7 DI DMNFVO7 DMNFVO7 DN Vinylsulphones DMNFVO7 MI TTEAID7 DMNFVO7 MN Trypanosoma Cruzipain (Trypano CYSP) DMNFVO7 MT DTT DMNFVO7 MA Binder DMNFVO7 RN Opportunities and challenges in antiparasitic drug discovery. Nat Rev Drug Discov. 2005 Sep;4(9):727-40. DMNFVO7 RU https://pubmed.ncbi.nlm.nih.gov/16138106 DMAXOPS DI DMAXOPS DMAXOPS DN viral macrophage inflammatory protein-II DMAXOPS MI TT8KLPT DMAXOPS MN C-C chemokine receptor (CCR) DMAXOPS MT DTT DMAXOPS MA Antagonist DMAXOPS RN A broad-spectrum chemokine antagonist encoded by Kaposi's sarcoma-associated herpesvirus. Science. 1997 Sep 12;277(5332):1656-9. DMAXOPS RU https://pubmed.ncbi.nlm.nih.gov/9287217 DMAXOPS DI DMAXOPS DMAXOPS DN viral macrophage inflammatory protein-II DMAXOPS MI TTFZYTO DMAXOPS MN C-C chemokine receptor type 2 (CCR2) DMAXOPS MT DTT DMAXOPS MA Antagonist DMAXOPS RN A broad-spectrum chemokine antagonist encoded by Kaposi's sarcoma-associated herpesvirus. Science. 1997 Sep 12;277(5332):1656-9. DMAXOPS RU https://pubmed.ncbi.nlm.nih.gov/9287217 DMAXOPS DI DMAXOPS DMAXOPS DN viral macrophage inflammatory protein-II DMAXOPS MI TTE836A DMAXOPS MN C-C chemokine receptor type 8 (CCR8) DMAXOPS MT DTT DMAXOPS MA Antagonist DMAXOPS RN HHV8-encoded vMIP-I selectively engages chemokine receptor CCR8. Agonist and antagonist profiles of viral chemokines. J Biol Chem. 1999 Jul 30;274(31):21569-74. DMAXOPS RU https://pubmed.ncbi.nlm.nih.gov/10419462 DMAXOPS DI DMAXOPS DMAXOPS DN viral macrophage inflammatory protein-II DMAXOPS MI TTJIH8Q DMAXOPS MN CCR5 messenger RNA (CCR5 mRNA) DMAXOPS MT DTT DMAXOPS MA Antagonist DMAXOPS RN A broad-spectrum chemokine antagonist encoded by Kaposi's sarcoma-associated herpesvirus. Science. 1997 Sep 12;277(5332):1656-9. DMAXOPS RU https://pubmed.ncbi.nlm.nih.gov/9287217 DMAXOPS DI DMAXOPS DMAXOPS DN viral macrophage inflammatory protein-II DMAXOPS MI TTBID49 DMAXOPS MN C-X-C chemokine receptor type 4 (CXCR4) DMAXOPS MT DTT DMAXOPS MA Antagonist DMAXOPS RN A broad-spectrum chemokine antagonist encoded by Kaposi's sarcoma-associated herpesvirus. Science. 1997 Sep 12;277(5332):1656-9. DMAXOPS RU https://pubmed.ncbi.nlm.nih.gov/9287217 DMCSHE8 DI DMCSHE8 DMCSHE8 DN visnagin DMCSHE8 MI TTNE7KG DMCSHE8 MN Adenosine A2b receptor (ADORA2B) DMCSHE8 MT DTT DMCSHE8 MA Antagonist DMCSHE8 RN Synthesis and biological activities of flavonoid derivatives as A3 adenosine receptor antagonists. J Med Chem. 1996 Jun 7;39(12):2293-301. DMCSHE8 RU https://pubmed.ncbi.nlm.nih.gov/8691424 DMCSHE8 DI DMCSHE8 DMCSHE8 DN visnagin DMCSHE8 MI TTJFY5U DMCSHE8 MN Adenosine A3 receptor (ADORA3) DMCSHE8 MT DTT DMCSHE8 MA Antagonist DMCSHE8 RN Synthesis and biological activities of flavonoid derivatives as A3 adenosine receptor antagonists. J Med Chem. 1996 Jun 7;39(12):2293-301. DMCSHE8 RU https://pubmed.ncbi.nlm.nih.gov/8691424 DMN6EZY DI DMN6EZY DMN6EZY DN Vitamin K DMN6EZY MI TT6L509 DMN6EZY MN Coagulation factor IIa (F2) DMN6EZY MT DTT DMN6EZY MA Cofactor DMN6EZY RN Plasma levels of protein C and vitamin K-dependent coagulation factors in patients on long-term oral anticoagulant therapy. Tohoku J Exp Med. 1986 Aug;149(4):351-7. DMN6EZY RU https://pubmed.ncbi.nlm.nih.gov/3775760 DMN6EZY DI DMN6EZY DMN6EZY DN Vitamin K DMN6EZY MI DEVRYQN DMN6EZY MN Vitamin K1 2,3-epoxide reductase 1 (VKOR) DMN6EZY MT DME DMN6EZY MA Metabolism DMN6EZY RN VKORC1L1, an enzyme mediating the effect of vitamin K in liver and extrahepatic tissues. Nutrients. 2018 Jul 26;10(8). pii: E970. DMN6EZY RU https://www.ncbi.nlm.nih.gov/pubmed/?term=30050002 DMN6EZY DI DMN6EZY DMN6EZY DN Vitamin K DMN6EZY MI DERQV72 DMN6EZY MN VKORC1-like protein 1 (VKORC1L1) DMN6EZY MT DME DMN6EZY MA Metabolism DMN6EZY RN VKORC1L1, an enzyme rescuing the vitamin K 2,3-epoxide reductase activity in some extrahepatic tissues during anticoagulation therapy. J Biol Chem. 2013 Oct 4;288(40):28733-42. DMN6EZY RU https://www.ncbi.nlm.nih.gov/pubmed/?term=23928358 DMJB3E1 DI DMJB3E1 DMJB3E1 DN VITAMIN K2 DMJB3E1 MI TTEAID7 DMJB3E1 MN Trypanosoma Cruzipain (Trypano CYSP) DMJB3E1 MT DTT DMJB3E1 MA Inhibitor DMJB3E1 RN Colloid formation by drugs in simulated intestinal fluid. J Med Chem. 2010 May 27;53(10):4259-65. DMJB3E1 RU https://pubmed.ncbi.nlm.nih.gov/20426472 DM7FQD0 DI DM7FQD0 DM7FQD0 DN VK-11 DM7FQD0 MI TTE4KHA DM7FQD0 MN Amyloid beta A4 protein (APP) DM7FQD0 MT DTT DM7FQD0 MA Inhibitor DM7FQD0 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2402). DM7FQD0 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2402 DMRQBEW DI DMRQBEW DMRQBEW DN VK-12 DMRQBEW MI TTE4KHA DMRQBEW MN Amyloid beta A4 protein (APP) DMRQBEW MT DTT DMRQBEW MA Inhibitor DMRQBEW RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2402). DMRQBEW RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2402 DMKW5YL DI DMKW5YL DMKW5YL DN VL-0395 DMKW5YL MI TTCG0AL DMKW5YL MN Cholecystokinin receptor type A (CCKAR) DMKW5YL MT DTT DMKW5YL MA Inhibitor DMKW5YL RN 2D-QSAR and 3D-QSAR/CoMFA analyses of the N-terminal substituted anthranilic acid based CCK(1) receptor antagonists: 'Hic Rhodus, hic saltus'. Bioorg Med Chem. 2009 Jul 15;17(14):5198-206. DMKW5YL RU https://pubmed.ncbi.nlm.nih.gov/19523833 DM2XAUY DI DM2XAUY DM2XAUY DN VL-0494 DM2XAUY MI TTCG0AL DM2XAUY MN Cholecystokinin receptor type A (CCKAR) DM2XAUY MT DTT DM2XAUY MA Inhibitor DM2XAUY RN Synthesis and evaluation of novel benzimidazole derivative [Bz-Im] and its radio/biological studies. Bioorg Med Chem Lett. 2007 May 15;17(10):2749-55. DM2XAUY RU https://pubmed.ncbi.nlm.nih.gov/17368898 DMCZNB3 DI DMCZNB3 DMCZNB3 DN VL-0699 DMCZNB3 MI TTCG0AL DMCZNB3 MN Cholecystokinin receptor type A (CCKAR) DMCZNB3 MT DTT DMCZNB3 MA Inhibitor DMCZNB3 RN Anthranilic acid based CCK1 receptor antagonists and CCK-8 have a common step in their "receptor desmodynamic processes". J Med Chem. 2006 Apr 20;49(8):2456-62. DMCZNB3 RU https://pubmed.ncbi.nlm.nih.gov/16610788 DMU9VQJ DI DMU9VQJ DMU9VQJ DN VL-1499 DMU9VQJ MI TTCG0AL DMU9VQJ MN Cholecystokinin receptor type A (CCKAR) DMU9VQJ MT DTT DMU9VQJ MA Inhibitor DMU9VQJ RN 2D-QSAR and 3D-QSAR/CoMFA analyses of the N-terminal substituted anthranilic acid based CCK(1) receptor antagonists: 'Hic Rhodus, hic saltus'. Bioorg Med Chem. 2009 Jul 15;17(14):5198-206. DMU9VQJ RU https://pubmed.ncbi.nlm.nih.gov/19523833 DMBEV4W DI DMBEV4W DMBEV4W DN VL-2799 DMBEV4W MI TTCG0AL DMBEV4W MN Cholecystokinin receptor type A (CCKAR) DMBEV4W MT DTT DMBEV4W MA Inhibitor DMBEV4W RN Anthranilic acid based CCK1 receptor antagonists: blocking the receptor with the same 'words' of the endogenous ligand. Bioorg Med Chem. 2009 Mar 15;17(6):2336-50. DMBEV4W RU https://pubmed.ncbi.nlm.nih.gov/19261479 DM95KRY DI DM95KRY DM95KRY DN VLI-27 DM95KRY MI TTWTSCV DM95KRY MN RAC-alpha serine/threonine-protein kinase (AKT1) DM95KRY MT DTT DM95KRY MA Inhibitor DM95KRY RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1479). DM95KRY RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1479 DMYH3A0 DI DMYH3A0 DMYH3A0 DN VLTS-582 DMYH3A0 MI TT6RVLG DMYH3A0 MN Superoxide dismutase Cu-Zn (SOD Cu-Zn) DMYH3A0 MT DTT DMYH3A0 MA Modulator DMYH3A0 RN A Phase I Study of Concurrent Chemotherapy (Paclitaxel and Carboplatin) and Thoracic Radiotherapy with Swallowed Manganese Superoxide Dismutase Plasmid Liposome Protection in Patients with Locally Advanced Stage III Non-Small-Cell Lung Cancer DMYH3A0 RU https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3057216 DMJRI6A DI DMJRI6A DMJRI6A DN VN/107-1 DMJRI6A MI TTRA5BZ DMJRI6A MN Steroid 17-alpha-monooxygenase (S17AH) DMJRI6A MT DTT DMJRI6A MA Inhibitor DMJRI6A RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1361). DMJRI6A RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1361 DMA106W DI DMA106W DMA106W DN Voacangine DMA106W MI TT1RS9F DMA106W MN Acetylcholinesterase (AChE) DMA106W MT DTT DMA106W MA Inhibitor DMA106W RN Indole alkaloids from Ervatamia hainanensis with potent acetylcholinesterase inhibition activities. Bioorg Med Chem Lett. 2010 Nov 1;20(21):6185-7. DMA106W RU https://pubmed.ncbi.nlm.nih.gov/20850311 DMT03VB DI DMT03VB DMT03VB DN VP-343 DMT03VB MI TTK8R02 DMT03VB MN Vasopressin V2 receptor (V2R) DMT03VB MT DTT DMT03VB MA Antagonist DMT03VB RN Nonpeptide vasopressin receptor antagonists: development of selective and orally active V1a, V2 and V1b receptor ligands. Prog Brain Res. 2002;139:197-210. DMT03VB RU https://pubmed.ncbi.nlm.nih.gov/12436936 DMIXUM3 DI DMIXUM3 DMIXUM3 DN VPC03090-P DMIXUM3 MI TT9JZCK DMIXUM3 MN Sphingosine-1-phosphate receptor 1 (S1PR1) DMIXUM3 MT DTT DMIXUM3 MA Antagonist DMIXUM3 RN Characterization of a sphingosine 1-phosphate receptor antagonist prodrug. J Pharmacol Exp Ther. 2011 Sep;338(3):879-89. DMIXUM3 RU https://pubmed.ncbi.nlm.nih.gov/21632869 DMIXUM3 DI DMIXUM3 DMIXUM3 DN VPC03090-P DMIXUM3 MI TTDYP7I DMIXUM3 MN Sphingosine-1-phosphate receptor 3 (S1PR3) DMIXUM3 MT DTT DMIXUM3 MA Antagonist DMIXUM3 RN Characterization of a sphingosine 1-phosphate receptor antagonist prodrug. J Pharmacol Exp Ther. 2011 Sep;338(3):879-89. DMIXUM3 RU https://pubmed.ncbi.nlm.nih.gov/21632869 DMIXUM3 DI DMIXUM3 DMIXUM3 DN VPC03090-P DMIXUM3 MI TTZ8C5Q DMIXUM3 MN Sphingosine-1-phosphate receptor 4 (S1PR4) DMIXUM3 MT DTT DMIXUM3 MA Agonist DMIXUM3 RN Characterization of a sphingosine 1-phosphate receptor antagonist prodrug. J Pharmacol Exp Ther. 2011 Sep;338(3):879-89. DMIXUM3 RU https://pubmed.ncbi.nlm.nih.gov/21632869 DMIXUM3 DI DMIXUM3 DMIXUM3 DN VPC03090-P DMIXUM3 MI TTDZCKV DMIXUM3 MN Sphingosine-1-phosphate receptor 5 (S1PR5) DMIXUM3 MT DTT DMIXUM3 MA Agonist DMIXUM3 RN Characterization of a sphingosine 1-phosphate receptor antagonist prodrug. J Pharmacol Exp Ther. 2011 Sep;338(3):879-89. DMIXUM3 RU https://pubmed.ncbi.nlm.nih.gov/21632869 DM6F0VR DI DM6F0VR DM6F0VR DN VPC12249 DM6F0VR MI TTE2YJR DM6F0VR MN Lysophosphatidate-3 receptor (LPAR3) DM6F0VR MT DTT DM6F0VR MA Antagonist DM6F0VR RN Activity of 2-substituted lysophosphatidic acid (LPA) analogs at LPA receptors: discovery of a LPA1/LPA3 receptor antagonist. Mol Pharmacol. 2001 Dec;60(6):1173-80. DM6F0VR RU https://pubmed.ncbi.nlm.nih.gov/11723223 DM6F0VR DI DM6F0VR DM6F0VR DN VPC12249 DM6F0VR MI TTQ6S1K DM6F0VR MN Lysophosphatidic acid receptor 1 (LPAR1) DM6F0VR MT DTT DM6F0VR MA Antagonist DM6F0VR RN Activity of 2-substituted lysophosphatidic acid (LPA) analogs at LPA receptors: discovery of a LPA1/LPA3 receptor antagonist. Mol Pharmacol. 2001 Dec;60(6):1173-80. DM6F0VR RU https://pubmed.ncbi.nlm.nih.gov/11723223 DM6F0VR DI DM6F0VR DM6F0VR DN VPC12249 DM6F0VR MI TTDYP7I DM6F0VR MN Sphingosine-1-phosphate receptor 3 (S1PR3) DM6F0VR MT DTT DM6F0VR MA Agonist DM6F0VR RN Synthesis and biological evaluation of gamma-aminophosphonates as potent, subtype-selective sphingosine 1-phosphate receptor agonists and antagonists. Bioorg Med Chem. 2007 Jan 15;15(2):663-77. DM6F0VR RU https://pubmed.ncbi.nlm.nih.gov/17113298 DMVQFY4 DI DMVQFY4 DMVQFY4 DN VPC23019 DMVQFY4 MI TT9JZCK DMVQFY4 MN Sphingosine-1-phosphate receptor 1 (S1PR1) DMVQFY4 MT DTT DMVQFY4 MA Antagonist DMVQFY4 RN Sphingosine 1-phosphate analogs as receptor antagonists. J Biol Chem. 2005 Mar 18;280(11):9833-41. DMVQFY4 RU https://pubmed.ncbi.nlm.nih.gov/15590668 DMVQFY4 DI DMVQFY4 DMVQFY4 DN VPC23019 DMVQFY4 MI TTDYP7I DMVQFY4 MN Sphingosine-1-phosphate receptor 3 (S1PR3) DMVQFY4 MT DTT DMVQFY4 MA Antagonist DMVQFY4 RN Sphingosine 1-phosphate analogs as receptor antagonists. J Biol Chem. 2005 Mar 18;280(11):9833-41. DMVQFY4 RU https://pubmed.ncbi.nlm.nih.gov/15590668 DMLK3I9 DI DMLK3I9 DMLK3I9 DN VPC32183 DMLK3I9 MI TTE2YJR DMLK3I9 MN Lysophosphatidate-3 receptor (LPAR3) DMLK3I9 MT DTT DMLK3I9 MA Antagonist DMLK3I9 RN Initial structure-activity relationships of lysophosphatidic acid receptor antagonists: discovery of a high-affinity LPA1/LPA3 receptor antagonist. Bioorg Med Chem Lett. 2004 Jun 7;14(11):2735-40. DMLK3I9 RU https://pubmed.ncbi.nlm.nih.gov/15125924 DMLK3I9 DI DMLK3I9 DMLK3I9 DN VPC32183 DMLK3I9 MI TTQ6S1K DMLK3I9 MN Lysophosphatidic acid receptor 1 (LPAR1) DMLK3I9 MT DTT DMLK3I9 MA Antagonist DMLK3I9 RN Initial structure-activity relationships of lysophosphatidic acid receptor antagonists: discovery of a high-affinity LPA1/LPA3 receptor antagonist. Bioorg Med Chem Lett. 2004 Jun 7;14(11):2735-40. DMLK3I9 RU https://pubmed.ncbi.nlm.nih.gov/15125924 DMQ4OTJ DI DMQ4OTJ DMQ4OTJ DN VPC44116 DMQ4OTJ MI TT9JZCK DMQ4OTJ MN Sphingosine-1-phosphate receptor 1 (S1PR1) DMQ4OTJ MT DTT DMQ4OTJ MA Antagonist DMQ4OTJ RN Synthesis and biological evaluation of gamma-aminophosphonates as potent, subtype-selective sphingosine 1-phosphate receptor agonists and antagonists. Bioorg Med Chem. 2007 Jan 15;15(2):663-77. DMQ4OTJ RU https://pubmed.ncbi.nlm.nih.gov/17113298 DMQ4OTJ DI DMQ4OTJ DMQ4OTJ DN VPC44116 DMQ4OTJ MI TTDYP7I DMQ4OTJ MN Sphingosine-1-phosphate receptor 3 (S1PR3) DMQ4OTJ MT DTT DMQ4OTJ MA Antagonist DMQ4OTJ RN Synthesis and biological evaluation of gamma-aminophosphonates as potent, subtype-selective sphingosine 1-phosphate receptor agonists and antagonists. Bioorg Med Chem. 2007 Jan 15;15(2):663-77. DMQ4OTJ RU https://pubmed.ncbi.nlm.nih.gov/17113298 DMQ4OTJ DI DMQ4OTJ DMQ4OTJ DN VPC44116 DMQ4OTJ MI TTDZCKV DMQ4OTJ MN Sphingosine-1-phosphate receptor 5 (S1PR5) DMQ4OTJ MT DTT DMQ4OTJ MA Agonist DMQ4OTJ RN Synthesis and biological evaluation of gamma-aminophosphonates as potent, subtype-selective sphingosine 1-phosphate receptor agonists and antagonists. Bioorg Med Chem. 2007 Jan 15;15(2):663-77. DMQ4OTJ RU https://pubmed.ncbi.nlm.nih.gov/17113298 DM20AJ4 DI DM20AJ4 DM20AJ4 DN VPC-94075 DM20AJ4 MI TTOHFIY DM20AJ4 MN Sphingosine kinase 1 (SPHK1) DM20AJ4 MT DTT DM20AJ4 MA Inhibitor DM20AJ4 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2204). DM20AJ4 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2204 DM1QKVL DI DM1QKVL DM1QKVL DN VRC3375 DM1QKVL MI TTICO5G DM1QKVL MN Staphylococcus Peptide deformylase (Stap-coc def) DM1QKVL MT DTT DM1QKVL MA Inhibitor DM1QKVL RN Peptide deformylase inhibitors as antibacterial agents: identification of VRC3375, a proline-3-alkylsuccinyl hydroxamate derivative, by using an integrated combinatorial and medicinal chemistry approach. Antimicrob Agents Chemother. 2004 Jan;48(1):250-61. DM1QKVL RU https://pubmed.ncbi.nlm.nih.gov/14693547 DMFT49S DI DMFT49S DMFT49S DN VRT-750018 DMFT49S MI TTOU65C DMFT49S MN Tyrosine-protein kinase SYK (SYK) DMFT49S MT DTT DMFT49S MA Inhibitor DMFT49S RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2230). DMFT49S RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2230 DMCXZGU DI DMCXZGU DMCXZGU DN VRX-03011 DMCXZGU MI TT07C3Y DMCXZGU MN 5-HT 4 receptor (HTR4) DMCXZGU MT DTT DMCXZGU MA Modulator DMCXZGU RN VRX-03011, a novel 5-HT4 agonist, enhances memory and hippocampal acetylcholine efflux.Neuropharmacology.2007 Sep;53(4):563-73. DMCXZGU RU https://www.ncbi.nlm.nih.gov/pubmed/17692343 DMRP2IN DI DMRP2IN DMRP2IN DN VS-12343 DMRP2IN MI DE62N9Z DMRP2IN MN Alpha-L-rhamnosidase (lrA) DMRP2IN MT DME DMRP2IN MA Metabolism DMRP2IN RN Catabolism of citrus flavanones by the probiotics Bifidobacterium longum and Lactobacillus rhamnosus. Eur J Nutr. 2018 Feb;57(1):231-242. DMRP2IN RU https://pubmed.ncbi.nlm.nih.gov/27722779 DMB7I0A DI DMB7I0A DMB7I0A DN VT-224 DMB7I0A MI TT8KLPT DMB7I0A MN C-C chemokine receptor (CCR) DMB7I0A MT DTT DMB7I0A MA Modulator DMB7I0A RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 67). DMB7I0A RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=67 DM1QBXM DI DM1QBXM DM1QBXM DN VT-310 DM1QBXM MI TTJTRMK DM1QBXM MN Interleukin 10 receptor (IL10RB) DM1QBXM MT DTT DM1QBXM MA Modulator DM1QBXM RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1900). DM1QBXM RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1900 DMG1Q0W DI DMG1Q0W DMG1Q0W DN VT-362 DMG1Q0W MI TT2GM5R DMG1Q0W MN Lymphocyte activation antigen CD30 (TNFRSF8) DMG1Q0W MT DTT DMG1Q0W MA Modulator DMG1Q0W RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1877). DMG1Q0W RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1877 DMJ2PG1 DI DMJ2PG1 DMJ2PG1 DN VTHRLAGLLSRSGGVVKNNFVPTNVGSKAF-NH2 DMJ2PG1 MI TTVSFJW DMJ2PG1 MN Calcitonin gene-related peptide 1 (CALCA) DMJ2PG1 MT DTT DMJ2PG1 MA Inhibitor DMJ2PG1 RN Identification of potent, selective, and metabolically stable peptide antagonists to the calcitonin gene-related peptide (CGRP) receptor. J Med Chem. 2008 Dec 25;51(24):7889-97. DMJ2PG1 RU https://pubmed.ncbi.nlm.nih.gov/19053766 DMT967L DI DMT967L DMT967L DN VTT-201 DMT967L MI TTS78AZ DMT967L MN Prostate specific antigen (KLK3) DMT967L MT DTT DMT967L MA Modulator DMT967L RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2373). DMT967L RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2373 DMEVAIF DI DMEVAIF DMEVAIF DN VTX-744 DMEVAIF MI TT8CWFK DMEVAIF MN Toll-like receptor 8 (TLR8) DMEVAIF MT DTT DMEVAIF MA Modulator DMEVAIF RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1758). DMEVAIF RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1758 DMGTB95 DI DMGTB95 DMGTB95 DN VTX-763 DMGTB95 MI TT8CWFK DMGTB95 MN Toll-like receptor 8 (TLR8) DMGTB95 MT DTT DMGTB95 MA Antagonist DMGTB95 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1758). DMGTB95 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1758 DMDF2U3 DI DMDF2U3 DMDF2U3 DN VU0001171 DMDF2U3 MI TTICZ1O DMDF2U3 MN Metabotropic glutamate receptor 4 (mGluR4) DMDF2U3 MT DTT DMDF2U3 MA Modulator (allosteric modulator) DMDF2U3 RN Positive allosteric modulators of the metabotropic glutamate receptor subtype 4 (mGluR4). Part II: Challenges in hit-to-lead. Bioorg Med Chem Lett. 2009 Feb 1;19(3):962-6. DMDF2U3 RU https://pubmed.ncbi.nlm.nih.gov/19097893 DMXD3T7 DI DMXD3T7 DMXD3T7 DN VU0010010 DMXD3T7 MI TTOXS3C DMXD3T7 MN Muscarinic acetylcholine receptor (CHRM) DMXD3T7 MT DTT DMXD3T7 MA Modulator (allosteric modulator) DMXD3T7 RN Subtype-selective allosteric modulators of muscarinic receptors for the treatment of CNS disorders. Trends Pharmacol Sci. 2009 Mar;30(3):148-55. DMXD3T7 RU https://pubmed.ncbi.nlm.nih.gov/19201489 DMRNLGW DI DMRNLGW DMRNLGW DN VU0029767 DMRNLGW MI TTOXS3C DMRNLGW MN Muscarinic acetylcholine receptor (CHRM) DMRNLGW MT DTT DMRNLGW MA Modulator (allosteric modulator) DMRNLGW RN Discovery and characterization of novel allosteric potentiators of M1 muscarinic receptors reveals multiple modes of activity. Mol Pharmacol. 2009 Mar;75(3):577-88. DMRNLGW RU https://pubmed.ncbi.nlm.nih.gov/19047481 DMUMOV1 DI DMUMOV1 DMUMOV1 DN VU0080241 DMUMOV1 MI TTVBPDM DMUMOV1 MN Metabotropic glutamate receptor 1 (mGluR1) DMUMOV1 MT DTT DMUMOV1 MA Inhibitor DMUMOV1 RN Positive allosteric modulators of the metabotropic glutamate receptor subtype 4 (mGluR4): Part I. Discovery of pyrazolo[3,4-d]pyrimidines as novel ... Bioorg Med Chem Lett. 2008 Oct 15;18(20):5626-30. DMUMOV1 RU https://pubmed.ncbi.nlm.nih.gov/18793851 DMGFTVI DI DMGFTVI DMGFTVI DN VU0090157 DMGFTVI MI TTOXS3C DMGFTVI MN Muscarinic acetylcholine receptor (CHRM) DMGFTVI MT DTT DMGFTVI MA Modulator (allosteric modulator) DMGFTVI RN Discovery and characterization of novel allosteric potentiators of M1 muscarinic receptors reveals multiple modes of activity. Mol Pharmacol. 2009 Mar;75(3):577-88. DMGFTVI RU https://pubmed.ncbi.nlm.nih.gov/19047481 DMVMXKP DI DMVMXKP DMVMXKP DN VU0092145 DMVMXKP MI TTICZ1O DMVMXKP MN Metabotropic glutamate receptor 4 (mGluR4) DMVMXKP MT DTT DMVMXKP MA Modulator (allosteric modulator) DMVMXKP RN Positive allosteric modulators of the metabotropic glutamate receptor subtype 4 (mGluR4). Part II: Challenges in hit-to-lead. Bioorg Med Chem Lett. 2009 Feb 1;19(3):962-6. DMVMXKP RU https://pubmed.ncbi.nlm.nih.gov/19097893 DMT76JS DI DMT76JS DMT76JS DN VU0092273 DMT76JS MI TTHS256 DMT76JS MN Metabotropic glutamate receptor 5 (mGluR5) DMT76JS MT DTT DMT76JS MA Modulator (allosteric modulator) DMT76JS RN Functional impact of allosteric agonist activity of selective positive allosteric modulators of metabotropic glutamate receptor subtype 5 in regulating central nervous system function. Mol Pharmacol.2012 Feb;81(2):120-33. DMT76JS RU https://pubmed.ncbi.nlm.nih.gov/22021324 DMPSI10 DI DMPSI10 DMPSI10 DN VU0119498 DMPSI10 MI TTH18TF DMPSI10 MN Muscarinic acetylcholine receptor M5 (CHRM5) DMPSI10 MT DTT DMPSI10 MA Inhibitor DMPSI10 RN Discovery of the first highly M5-preferring muscarinic acetylcholine receptor ligand, an M5 positive allosteric modulator derived from a series of ... J Med Chem. 2009 Jun 11;52(11):3445-8. DMPSI10 RU https://pubmed.ncbi.nlm.nih.gov/19438238 DM1UAQT DI DM1UAQT DM1UAQT DN VU0152099 DM1UAQT MI TTOXS3C DM1UAQT MN Muscarinic acetylcholine receptor (CHRM) DM1UAQT MT DTT DM1UAQT MA Modulator (allosteric modulator) DM1UAQT RN Centrally active allosteric potentiators of the M4 muscarinic acetylcholine receptor reverse amphetamine-induced hyperlocomotor activity in rats. J Pharmacol Exp Ther. 2008 Dec;327(3):941-53. DM1UAQT RU https://pubmed.ncbi.nlm.nih.gov/18772318 DM04HUC DI DM04HUC DM04HUC DN VU0152100 DM04HUC MI TTOXS3C DM04HUC MN Muscarinic acetylcholine receptor (CHRM) DM04HUC MT DTT DM04HUC MA Modulator (allosteric modulator) DM04HUC RN Centrally active allosteric potentiators of the M4 muscarinic acetylcholine receptor reverse amphetamine-induced hyperlocomotor activity in rats. J Pharmacol Exp Ther. 2008 Dec;327(3):941-53. DM04HUC RU https://pubmed.ncbi.nlm.nih.gov/18772318 DMPKSTD DI DMPKSTD DMPKSTD DN VU0155041 DMPKSTD MI TTICZ1O DMPKSTD MN Metabotropic glutamate receptor 4 (mGluR4) DMPKSTD MT DTT DMPKSTD MA Modulator (allosteric modulator) DMPKSTD RN Discovery, characterization, and antiparkinsonian effect of novel positive allosteric modulators of metabotropic glutamate receptor 4. Mol Pharmacol. 2008 Nov;74(5):1345-58. DMPKSTD RU https://pubmed.ncbi.nlm.nih.gov/18664603 DMOPLQI DI DMOPLQI DMOPLQI DN VU0238429 DMOPLQI MI TTH18TF DMOPLQI MN Muscarinic acetylcholine receptor M5 (CHRM5) DMOPLQI MT DTT DMOPLQI MA Inhibitor DMOPLQI RN Discovery of the first highly M5-preferring muscarinic acetylcholine receptor ligand, an M5 positive allosteric modulator derived from a series of ... J Med Chem. 2009 Jun 11;52(11):3445-8. DMOPLQI RU https://pubmed.ncbi.nlm.nih.gov/19438238 DMH720P DI DMH720P DMH720P DN VU0240382 DMH720P MI TTHS256 DMH720P MN Metabotropic glutamate receptor 5 (mGluR5) DMH720P MT DTT DMH720P MA Modulator (allosteric modulator) DMH720P RN Functional impact of allosteric agonist activity of selective positive allosteric modulators of metabotropic glutamate receptor subtype 5 in regulating central nervous system function. Mol Pharmacol.2012 Feb;81(2):120-33. DMH720P RU https://pubmed.ncbi.nlm.nih.gov/22021324 DMU3YRH DI DMU3YRH DMU3YRH DN VU0240551 DMU3YRH MI TTH6UZY DMU3YRH MN Solute carrier family 12 member 5 (SLC12A5) DMU3YRH MT DTT DMU3YRH MA Inhibitor DMU3YRH RN Small-molecule screen identifies inhibitors of the neuronal K-Cl cotransporter KCC2. Proc Natl Acad Sci U S A. 2009 Mar 31;106(13):5383-8. DMU3YRH RU https://pubmed.ncbi.nlm.nih.gov/19279215 DMRKE6W DI DMRKE6W DMRKE6W DN VU0255035 DMRKE6W MI TTOXS3C DMRKE6W MN Muscarinic acetylcholine receptor (CHRM) DMRKE6W MT DTT DMRKE6W MA Antagonist DMRKE6W RN A novel selective muscarinic acetylcholine receptor subtype 1 antagonist reduces seizures without impairing hippocampus-dependent learning. Mol Pharmacol. 2009 Aug;76(2):356-68. DMRKE6W RU https://pubmed.ncbi.nlm.nih.gov/19407080 DMRKE6W DI DMRKE6W DMRKE6W DN VU0255035 DMRKE6W MI TTQ13Z5 DMRKE6W MN Muscarinic acetylcholine receptor M3 (CHRM3) DMRKE6W MT DTT DMRKE6W MA Antagonist DMRKE6W RN A novel selective muscarinic acetylcholine receptor subtype 1 antagonist reduces seizures without impairing hippocampus-dependent learning. Mol Pharmacol. 2009 Aug;76(2):356-68. DMRKE6W RU https://pubmed.ncbi.nlm.nih.gov/19407080 DM7VCDF DI DM7VCDF DM7VCDF DN VU0285683 DM7VCDF MI TTHS256 DM7VCDF MN Metabotropic glutamate receptor 5 (mGluR5) DM7VCDF MT DTT DM7VCDF MA Modulator (allosteric modulator) DM7VCDF RN Discovery of novel allosteric modulators of metabotropic glutamate receptor subtype 5 reveals chemical and functional diversity and in vivo activity in rat behavioral models of anxiolytic and antipsychotic activity. Mol Pharmacol. 2010 Dec;78(6):1105-23. DM7VCDF RU https://pubmed.ncbi.nlm.nih.gov/20923853 DMETUHS DI DMETUHS DMETUHS DN VU0357121 DMETUHS MI TTHS256 DMETUHS MN Metabotropic glutamate receptor 5 (mGluR5) DMETUHS MT DTT DMETUHS MA Modulator (allosteric modulator) DMETUHS RN Discovery of a Novel Chemical Class of mGlu(5) Allosteric Ligands with Distinct Modes of Pharmacology. ACS Chem Neurosci. 2010 Oct 20;1(10):702-716. DMETUHS RU https://pubmed.ncbi.nlm.nih.gov/20981342 DM9V01W DI DM9V01W DM9V01W DN VU0359516 DM9V01W MI TTICZ1O DM9V01W MN Metabotropic glutamate receptor 4 (mGluR4) DM9V01W MT DTT DM9V01W MA Modulator (allosteric modulator) DM9V01W RN Re-exploration of the PHCCC Scaffold: Discovery of Improved Positive Allosteric Modulators of mGluR4. ACS Chem Neurosci. 2010 Jun 16;1(6):411-419. DM9V01W RU https://pubmed.ncbi.nlm.nih.gov/20582156 DM3NXMB DI DM3NXMB DM3NXMB DN VU0360172 DM3NXMB MI TTHS256 DM3NXMB MN Metabotropic glutamate receptor 5 (mGluR5) DM3NXMB MT DTT DM3NXMB MA Modulator (allosteric modulator) DM3NXMB RN Discovery of novel allosteric modulators of metabotropic glutamate receptor subtype 5 reveals chemical and functional diversity and in vivo activity in rat behavioral models of anxiolytic and antipsychotic activity. Mol Pharmacol. 2010 Dec;78(6):1105-23. DM3NXMB RU https://pubmed.ncbi.nlm.nih.gov/20923853 DME71ON DI DME71ON DME71ON DN VU0361737 DME71ON MI TTICZ1O DME71ON MN Metabotropic glutamate receptor 4 (mGluR4) DME71ON MT DTT DME71ON MA Modulator (allosteric modulator) DME71ON RN Synthesis and evaluation of a series of heterobiarylamides that are centrally penetrant metabotropic glutamate receptor 4 (mGluR4) positive allosteric modulators (PAMs). J Med Chem. 2009 Jul 23;52(14):4115-8. DME71ON RU https://pubmed.ncbi.nlm.nih.gov/19469556 DM3ZUH2 DI DM3ZUH2 DM3ZUH2 DN VU0361747 DM3ZUH2 MI TTHS256 DM3ZUH2 MN Metabotropic glutamate receptor 5 (mGluR5) DM3ZUH2 MT DTT DM3ZUH2 MA Modulator (allosteric modulator) DM3ZUH2 RN Functional impact of allosteric agonist activity of selective positive allosteric modulators of metabotropic glutamate receptor subtype 5 in regulating central nervous system function. Mol Pharmacol.2012 Feb;81(2):120-33. DM3ZUH2 RU https://pubmed.ncbi.nlm.nih.gov/22021324 DM8TR1Y DI DM8TR1Y DM8TR1Y DN VU0364289 DM8TR1Y MI TTHS256 DM8TR1Y MN Metabotropic glutamate receptor 5 (mGluR5) DM8TR1Y MT DTT DM8TR1Y MA Modulator (allosteric modulator) DM8TR1Y RN Discovery of N-Aryl Piperazines as Selective mGlu(5) Potentiators with Efficacy in a Rodent Model Predictive of Anti-Psychotic Activity. ACS Med Chem Lett. 2010 Nov 11;1(8):433-438. DM8TR1Y RU https://pubmed.ncbi.nlm.nih.gov/23308336 DMXY980 DI DMXY980 DMXY980 DN VU0364770 DMXY980 MI TTICZ1O DMXY980 MN Metabotropic glutamate receptor 4 (mGluR4) DMXY980 MT DTT DMXY980 MA Modulator (allosteric modulator) DMXY980 RN The metabotropic glutamate receptor 4-positive allosteric modulator VU0364770 produces efficacy alone and in combination with L-DOPA or an adenosine 2A antagonist in preclinical rodent models of Parkinson's disease. J Pharmacol Exp Ther. 2012 Feb;340(2):404-21. DMXY980 RU https://pubmed.ncbi.nlm.nih.gov/22088953 DMA6CLO DI DMA6CLO DMA6CLO DN VU0366058 DMA6CLO MI TTHS256 DMA6CLO MN Metabotropic glutamate receptor 5 (mGluR5) DMA6CLO MT DTT DMA6CLO MA Modulator (allosteric modulator) DMA6CLO RN Discovery of 2-(2-benzoxazoyl amino)-4-aryl-5-cyanopyrimidine as negative allosteric modulators (NAMs) of metabotropic glutamate receptor (mGlu : from an artificial neural network virtual screen to an in vivo tool compound. ChemMedChem. 2012 Mar 5;7(3):406-14. DMA6CLO RU https://pubmed.ncbi.nlm.nih.gov/22267125 DM7L51U DI DM7L51U DM7L51U DN VU0400195 DM7L51U MI TTICZ1O DM7L51U MN Metabotropic glutamate receptor 4 (mGluR4) DM7L51U MT DTT DM7L51U MA Modulator (allosteric modulator) DM7L51U RN Discovery, synthesis, and structure-activity relationship development of a series of N-4-(2,5-dioxopyrrolidin-1-yl)phenylpicolinamides (VU0400195, ML182): characterization of a novel positive allosteric modulator of the metabotropic glutamate receptor 4 (mGlu(4)) with oral efficacy in an antiparkinsonian animal model. J Med Chem. 2011 Nov 10;54(21):7639-47. DM7L51U RU https://pubmed.ncbi.nlm.nih.gov/21966889 DMZRE6X DI DMZRE6X DMZRE6X DN VU0404251 DMZRE6X MI TTHS256 DMZRE6X MN Metabotropic glutamate receptor 5 (mGluR5) DMZRE6X MT DTT DMZRE6X MA Modulator (allosteric modulator) DMZRE6X RN Optimization of an ether series of mGlu5 positive allosteric modulators: molecular determinants of MPEP-site interaction crossover. Bioorg Med Chem Lett. 2012 Oct 15;22(20):6481-5. DMZRE6X RU https://pubmed.ncbi.nlm.nih.gov/22981332 DMLPMAY DI DMLPMAY DMLPMAY DN VU0405601 DMLPMAY MI TTQ6VDM DMLPMAY MN Voltage-gated potassium channel Kv11.1 (KCNH2) DMLPMAY MT DTT DMLPMAY MA Activator DMLPMAY RN Identification and characterization of a compound that protects cardiac tissue from human Ether- -go-go-related gene (hERG)-related drug-induced arrhythmias. J Biol Chem. 2012 Nov 16;287(47):39613-25. DMLPMAY RU https://pubmed.ncbi.nlm.nih.gov/23033485 DMZDIVL DI DMZDIVL DMZDIVL DN VU0424465 DMZDIVL MI TTHS256 DMZDIVL MN Metabotropic glutamate receptor 5 (mGluR5) DMZDIVL MT DTT DMZDIVL MA Modulator (allosteric modulator) DMZDIVL RN Unique signaling profiles of positive allosteric modulators of metabotropic glutamate receptor subtype 5 determine differences in in vivo activity. Biol Psychiatry. 2013 Mar 15;73(6):501-9. DMZDIVL RU https://pubmed.ncbi.nlm.nih.gov/23140665 DM96FQ2 DI DM96FQ2 DM96FQ2 DN VU0463597 DM96FQ2 MI TT8A9EF DM96FQ2 MN Metabotropic glutamate receptor 3 (mGluR3) DM96FQ2 MT DTT DM96FQ2 MA Modulator (allosteric modulator) DM96FQ2 RN Development of a novel, CNS-penetrant, metabotropic glutamate receptor 3 (mGlu3) NAM probe (ML289) derived from a closely related mGlu5 PAM. Bioorg Med Chem Lett. 2012 Jun 15;22(12):3921-5. DM96FQ2 RU https://pubmed.ncbi.nlm.nih.gov/22607673 DMDW9MS DI DMDW9MS DMDW9MS DN VU0463841 DMDW9MS MI TTHS256 DMDW9MS MN Metabotropic glutamate receptor 5 (mGluR5) DMDW9MS MT DTT DMDW9MS MA Modulator (allosteric modulator) DMDW9MS RN Substituted 1-Phenyl-3-(pyridin-2-yl)urea negative allosteric modulators of mGlu5: discovery of a new tool compound VU0463841 with activity in rat models of cocaine addiction. ACS Chem Neurosci. 2013Aug 21;4(8):1217-28. DMDW9MS RU https://pubmed.ncbi.nlm.nih.gov/23682684 DM1H5DL DI DM1H5DL DM1H5DL DN VU0469650 DM1H5DL MI TTVBPDM DM1H5DL MN Metabotropic glutamate receptor 1 (mGluR1) DM1H5DL MT DTT DM1H5DL MA Modulator (allosteric modulator) DM1H5DL RN N-Acyl-N'-arylpiperazines as negative allosteric modulators of mGlu1: identification of VU0469650, a potent and selective tool compound with CNS exposure in rats. Bioorg Med Chem Lett. 2013 Jul 1;23(13):3713-8. DM1H5DL RU https://pubmed.ncbi.nlm.nih.gov/23727046 DM31V7K DI DM31V7K DM31V7K DN VU10007 DM31V7K MI TTQ3JTF DM31V7K MN Muscarinic acetylcholine receptor M4 (CHRM4) DM31V7K MT DTT DM31V7K MA Inhibitor DM31V7K RN An allosteric potentiator of M4 mAChR modulates hippocampal synaptic transmission. Nat Chem Biol. 2008 Jan;4(1):42-50. DM31V7K RU https://pubmed.ncbi.nlm.nih.gov/18059262 DM2HGCB DI DM2HGCB DM2HGCB DN VU10010 DM2HGCB MI TTQ3JTF DM2HGCB MN Muscarinic acetylcholine receptor M4 (CHRM4) DM2HGCB MT DTT DM2HGCB MA Inhibitor DM2HGCB RN An allosteric potentiator of M4 mAChR modulates hippocampal synaptic transmission. Nat Chem Biol. 2008 Jan;4(1):42-50. DM2HGCB RU https://pubmed.ncbi.nlm.nih.gov/18059262 DMCRF48 DI DMCRF48 DMCRF48 DN VU-1545 DMCRF48 MI TTHS256 DMCRF48 MN Metabotropic glutamate receptor 5 (mGluR5) DMCRF48 MT DTT DMCRF48 MA Modulator (allosteric modulator) DMCRF48 RN Substituent effects of N-(1,3-diphenyl-1H-pyrazol-5-yl)benzamides on positive allosteric modulation of the metabotropic glutamate-5 receptor in rat... J Med Chem. 2006 Jun 1;49(11):3332-44. DMCRF48 RU https://pubmed.ncbi.nlm.nih.gov/16722652 DMX9ED1 DI DMX9ED1 DMX9ED1 DN VU591 DMX9ED1 MI TTJ13ST DMX9ED1 MN Inward rectifier potassium channel Kir1.1 (KCNJ1) DMX9ED1 MT DTT DMX9ED1 MA Blocker (channel blocker) DMX9ED1 RN Development of a selective small-molecule inhibitor of Kir1.1, the renal outer medullary potassium channel. Mol Pharmacol. 2011 Jan;79(1):42-50. DMX9ED1 RU https://pubmed.ncbi.nlm.nih.gov/20926757 DMHX1KJ DI DMHX1KJ DMHX1KJ DN VU-71 DMHX1KJ MI TTVBPDM DMHX1KJ MN Metabotropic glutamate receptor 1 (mGluR1) DMHX1KJ MT DTT DMHX1KJ MA Modulator (allosteric modulator) DMHX1KJ RN 9H-Xanthene-9-carboxylic acid [1,2,4]oxadiazol-3-yl- and (2H-tetrazol-5-yl)-amides as potent, orally available mGlu1 receptor enhancers. Bioorg Med Chem Lett. 2005 Oct 15;15(20):4628-31. DMHX1KJ RU https://pubmed.ncbi.nlm.nih.gov/16099654 DMFPNRD DI DMFPNRD DMFPNRD DN VUF 4904 DMFPNRD MI TT9JNIC DMFPNRD MN Histamine H3 receptor (H3R) DMFPNRD MT DTT DMFPNRD MA Antagonist DMFPNRD RN Constitutive activity of histamine h(3) receptors stably expressed in SK-N-MC cells: display of agonism and inverse agonism by H(3) antagonists. J Pharmacol Exp Ther. 2001 Dec;299(3):908-14. DMFPNRD RU https://pubmed.ncbi.nlm.nih.gov/11714875 DMMNVGJ DI DMMNVGJ DMMNVGJ DN VUF 5207 DMMNVGJ MI TT9JNIC DMMNVGJ MN Histamine H3 receptor (H3R) DMMNVGJ MT DTT DMMNVGJ MA Agonist DMMNVGJ RN Constitutive activity of histamine h(3) receptors stably expressed in SK-N-MC cells: display of agonism and inverse agonism by H(3) antagonists. J Pharmacol Exp Ther. 2001 Dec;299(3):908-14. DMMNVGJ RU https://pubmed.ncbi.nlm.nih.gov/11714875 DMVFJR4 DI DMVFJR4 DMVFJR4 DN VUF 5681 DMVFJR4 MI TT9JNIC DMVFJR4 MN Histamine H3 receptor (H3R) DMVFJR4 MT DTT DMVFJR4 MA Antagonist DMVFJR4 RN The histamine H3 receptor: from gene cloning to H3 receptor drugs. Nat Rev Drug Discov. 2005 Feb;4(2):107-20. DMVFJR4 RU https://pubmed.ncbi.nlm.nih.gov/15665857 DMI6GD0 DI DMI6GD0 DMI6GD0 DN VUF 8328 DMI6GD0 MI TT9JNIC DMI6GD0 MN Histamine H3 receptor (H3R) DMI6GD0 MT DTT DMI6GD0 MA Agonist DMI6GD0 RN Constitutive activity of histamine h(3) receptors stably expressed in SK-N-MC cells: display of agonism and inverse agonism by H(3) antagonists. J Pharmacol Exp Ther. 2001 Dec;299(3):908-14. DMI6GD0 RU https://pubmed.ncbi.nlm.nih.gov/11714875 DMJC0UH DI DMJC0UH DMJC0UH DN VUF 8430 DMJC0UH MI TTXJ178 DMJC0UH MN Histamine H4 receptor (H4R) DMJC0UH MT DTT DMJC0UH MA Agonist DMJC0UH RN Discovery of S-(2-guanidylethyl)-isothiourea (VUF 8430) as a potent nonimidazole histamine H4 receptor agonist. J Med Chem. 2006 Nov 16;49(23):6650-1. DMJC0UH RU https://pubmed.ncbi.nlm.nih.gov/17154494 DM89PMC DI DM89PMC DM89PMC DN VUF-10148 DM89PMC MI TTTIBOJ DM89PMC MN Histamine H1 receptor (H1R) DM89PMC MT DTT DM89PMC MA Inhibitor DM89PMC RN Fragment based design of new H4 receptor-ligands with anti-inflammatory properties in vivo. J Med Chem. 2008 Apr 24;51(8):2457-67. DM89PMC RU https://pubmed.ncbi.nlm.nih.gov/18357976 DM89PMC DI DM89PMC DM89PMC DN VUF-10148 DM89PMC MI TTQHJ1K DM89PMC MN Histamine H2 receptor (H2R) DM89PMC MT DTT DM89PMC MA Inhibitor DM89PMC RN Fragment based design of new H4 receptor-ligands with anti-inflammatory properties in vivo. J Med Chem. 2008 Apr 24;51(8):2457-67. DM89PMC RU https://pubmed.ncbi.nlm.nih.gov/18357976 DMADEOQ DI DMADEOQ DMADEOQ DN VUF-10214 DMADEOQ MI TT9JNIC DMADEOQ MN Histamine H3 receptor (H3R) DMADEOQ MT DTT DMADEOQ MA Inhibitor DMADEOQ RN Fragment based design of new H4 receptor-ligands with anti-inflammatory properties in vivo. J Med Chem. 2008 Apr 24;51(8):2457-67. DMADEOQ RU https://pubmed.ncbi.nlm.nih.gov/18357976 DM3G6OK DI DM3G6OK DM3G6OK DN VUF-5297 DM3G6OK MI TT9JNIC DM3G6OK MN Histamine H3 receptor (H3R) DM3G6OK MT DTT DM3G6OK MA Inhibitor DM3G6OK RN Cyclopropane-based conformational restriction of histamine. (1S,2S)-2-(2-aminoethyl)-1-(1H-imidazol-4-yl)cyclopropane, a highly selective agonist f... J Med Chem. 2003 May 8;46(10):1980-8. DM3G6OK RU https://pubmed.ncbi.nlm.nih.gov/12723960 DMF1O0Z DI DMF1O0Z DMF1O0Z DN VUF5391 DMF1O0Z MI TT9JNIC DMF1O0Z MN Histamine H3 receptor (H3R) DMF1O0Z MT DTT DMF1O0Z MA Antagonist DMF1O0Z RN The histamine H3 receptor: from gene cloning to H3 receptor drugs. Nat Rev Drug Discov. 2005 Feb;4(2):107-20. DMF1O0Z RU https://pubmed.ncbi.nlm.nih.gov/15665857 DMUA751 DI DMUA751 DMUA751 DN VUF5574 DMUA751 MI TTK25J1 DMUA751 MN Adenosine A1 receptor (ADORA1) DMUA751 MT DTT DMUA751 MA Antagonist DMUA751 RN A novel class of adenosine A3 receptor ligands. 1. 3-(2-Pyridinyl)isoquinoline derivatives. J Med Chem. 1998 Oct 8;41(21):3987-93. DMUA751 RU https://pubmed.ncbi.nlm.nih.gov/9767636 DMUA751 DI DMUA751 DMUA751 DN VUF5574 DMUA751 MI TTNE7KG DMUA751 MN Adenosine A2b receptor (ADORA2B) DMUA751 MT DTT DMUA751 MA Antagonist DMUA751 RN A novel class of adenosine A3 receptor ligands. 1. 3-(2-Pyridinyl)isoquinoline derivatives. J Med Chem. 1998 Oct 8;41(21):3987-93. DMUA751 RU https://pubmed.ncbi.nlm.nih.gov/9767636 DMUA751 DI DMUA751 DMUA751 DN VUF5574 DMUA751 MI TTJFY5U DMUA751 MN Adenosine A3 receptor (ADORA3) DMUA751 MT DTT DMUA751 MA Antagonist DMUA751 RN Isoquinoline and quinazoline urea analogues as antagonists for the human adenosine A(3) receptor. J Med Chem. 2000 Jun 1;43(11):2227-38. DMUA751 RU https://pubmed.ncbi.nlm.nih.gov/10841801 DM8OTAG DI DM8OTAG DM8OTAG DN VUF-8504 DM8OTAG MI TTJFY5U DM8OTAG MN Adenosine A3 receptor (ADORA3) DM8OTAG MT DTT DM8OTAG MA Inhibitor DM8OTAG RN Pharmacophore based receptor modeling: the case of adenosine A3 receptor antagonists. An approach to the optimization of protein models. J Med Chem. 2006 Jul 13;49(14):4085-97. DM8OTAG RU https://pubmed.ncbi.nlm.nih.gov/16821770 DMQFWV7 DI DMQFWV7 DMQFWV7 DN VUF-8507 DMQFWV7 MI TTK25J1 DMQFWV7 MN Adenosine A1 receptor (ADORA1) DMQFWV7 MT DTT DMQFWV7 MA Inhibitor DMQFWV7 RN Isoquinoline and quinazoline urea analogues as antagonists for the human adenosine A(3) receptor. J Med Chem. 2000 Jun 1;43(11):2227-38. DMQFWV7 RU https://pubmed.ncbi.nlm.nih.gov/10841801 DMQFWV7 DI DMQFWV7 DMQFWV7 DN VUF-8507 DMQFWV7 MI TTJFY5U DMQFWV7 MN Adenosine A3 receptor (ADORA3) DMQFWV7 MT DTT DMQFWV7 MA Inhibitor DMQFWV7 RN Pharmacophore based receptor modeling: the case of adenosine A3 receptor antagonists. An approach to the optimization of protein models. J Med Chem. 2006 Jul 13;49(14):4085-97. DMQFWV7 RU https://pubmed.ncbi.nlm.nih.gov/16821770 DMWRX4T DI DMWRX4T DMWRX4T DN VULM-1457 DMWRX4T MI TTMF541 DMWRX4T MN Liver carboxylesterase (CES1) DMWRX4T MT DTT DMWRX4T MA Inhibitor DMWRX4T RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2592). DMWRX4T RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2592 DMEZAND DI DMEZAND DMEZAND DN VVP-100X DMEZAND MI TTCBFJO DMEZAND MN Insulin receptor (INSR) DMEZAND MT DTT DMEZAND MA Inhibitor DMEZAND RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1800). DMEZAND RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1800 DM4Q5DO DI DM4Q5DO DM4Q5DO DN VX-467 DM4Q5DO MI TTT7PJU DM4Q5DO MN Janus kinase 3 (JAK-3) DM4Q5DO MT DTT DM4Q5DO MA Inhibitor DM4Q5DO RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2049). DM4Q5DO RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2049 DMDYTSW DI DMDYTSW DMDYTSW DN W146 DMDYTSW MI TT9JZCK DMDYTSW MN Sphingosine-1-phosphate receptor 1 (S1PR1) DMDYTSW MT DTT DMDYTSW MA Antagonist DMDYTSW RN Enhancement of capillary leakage and restoration of lymphocyte egress by a chiral S1P1 antagonist in vivo. Nat Chem Biol. 2006 Aug;2(8):434-41. DMDYTSW RU https://pubmed.ncbi.nlm.nih.gov/16829954 DMQI7BA DI DMQI7BA DMQI7BA DN W54011 DMQI7BA MI TTHXFA1 DMQI7BA MN C5a anaphylatoxin chemotactic receptor (C5AR1) DMQI7BA MT DTT DMQI7BA MA Antagonist DMQI7BA RN Identification of a potent and orally active non-peptide C5a receptor antagonist. J Biol Chem. 2002 Dec 20;277(51):49403-7. DMQI7BA RU https://pubmed.ncbi.nlm.nih.gov/12384495 DMMBI9Y DI DMMBI9Y DMMBI9Y DN W-84 DMMBI9Y MI TTOXS3C DMMBI9Y MN Muscarinic acetylcholine receptor (CHRM) DMMBI9Y MT DTT DMMBI9Y MA Modulator (allosteric modulator) DMMBI9Y RN Interactions of orthosteric and allosteric ligands with [3H]dimethyl-W84 at the common allosteric site of muscarinic M2 receptors. Mol Pharmacol. 2003 Jul;64(1):180-90. DMMBI9Y RU https://pubmed.ncbi.nlm.nih.gov/12815174 DMNRBDP DI DMNRBDP DMNRBDP DN WA-8242-A1 DMNRBDP MI TT9V5JH DMNRBDP MN Phospholipase A2 (PLA2G1B) DMNRBDP MT DTT DMNRBDP MA Modulator DMNRBDP RN WA8242A1, A2 and B, novel secretary phospholipase A2 inhibitors produced by Streptomyces violaceusniger. III. Structure elucidation and total synth... J Antibiot (Tokyo). 1998 Jul;51(7):655-64. DMNRBDP RU https://www.ncbi.nlm.nih.gov/pubmed/9727392 DMB6H35 DI DMB6H35 DMB6H35 DN waixenicin A DMB6H35 MI TTFPVZO DMB6H35 MN Long transient receptor potential channel 7 (TRPM7) DMB6H35 MT DTT DMB6H35 MA Blocker (channel blocker) DMB6H35 RN Waixenicin A inhibits cell proliferation through magnesium-dependent block of transient receptor potential melastatin 7 (TRPM7) channels. J Biol Chem. 2011 Nov 11;286(45):39328-35. DMB6H35 RU https://pubmed.ncbi.nlm.nih.gov/21926172 DMC6KYF DI DMC6KYF DMC6KYF DN WAY 100135 DMC6KYF MI TTSQIFT DMC6KYF MN 5-HT 1A receptor (HTR1A) DMC6KYF MT DTT DMC6KYF MA Antagonist DMC6KYF RN Influence of 5-HT1A receptor antagonism on plus-maze behaviour in mice. II. WAY 100635, SDZ 216-525 and NAN-190. Pharmacol Biochem Behav. 1997 Oct;58(2):593-603. DMC6KYF RU https://pubmed.ncbi.nlm.nih.gov/9300624 DMCSZG0 DI DMCSZG0 DMCSZG0 DN WAY-125971 DMCSZG0 MI TT1VOHK DMCSZG0 MN Potassium channel unspecific (KC) DMCSZG0 MT DTT DMCSZG0 MA Modulator DMCSZG0 RN Synthesis and selective class III antiarrhythmic activity of novel N-heteroaralkyl-substituted 1-(aryloxy)-2-propanolamine and related propylamine derivatives. J Med Chem. 1991 Nov;34(11):3212-28. DMCSZG0 RU https://pubmed.ncbi.nlm.nih.gov/1956040 DMRWG0C DI DMRWG0C DMRWG0C DN WAY-151693 DMRWG0C MI TTHY57M DMRWG0C MN Matrix metalloproteinase-13 (MMP-13) DMRWG0C MT DTT DMRWG0C MA Inhibitor DMRWG0C RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMRWG0C RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMNMO4Q DI DMNMO4Q DMNMO4Q DN WAY-163909 DMNMO4Q MI TTWJBZ5 DMNMO4Q MN 5-HT 2C receptor (HTR2C) DMNMO4Q MT DTT DMNMO4Q MA Agonist DMNMO4Q RN WAY-163909 [(7bR, 10aR)-1,2,3,4,8,9,10,10a-octahydro-7bH-cyclopenta-[b][1,4]diazepino[6,7,1hi]indole], a novel 5-hydroxytryptamine 2C receptor-sele... J Pharmacol Exp Ther. 2005 May;313(2):862-9. DMNMO4Q RU https://pubmed.ncbi.nlm.nih.gov/15705738 DM94KWA DI DM94KWA DM94KWA DN WAY-169916 DM94KWA MI TTZAYWL DM94KWA MN Estrogen receptor (ESR) DM94KWA MT DTT DM94KWA MA Inhibitor DM94KWA RN Synthesis and activity of substituted 4-(indazol-3-yl)phenols as pathway-selective estrogen receptor ligands useful in the treatment of rheumatoid ... J Med Chem. 2004 Dec 16;47(26):6435-8. DM94KWA RU https://pubmed.ncbi.nlm.nih.gov/15588074 DM94KWA DI DM94KWA DM94KWA DN WAY-169916 DM94KWA MI TTOM3J0 DM94KWA MN Estrogen receptor beta (ESR2) DM94KWA MT DTT DM94KWA MA Inhibitor DM94KWA RN Synthesis and activity of substituted 4-(indazol-3-yl)phenols as pathway-selective estrogen receptor ligands useful in the treatment of rheumatoid ... J Med Chem. 2004 Dec 16;47(26):6435-8. DM94KWA RU https://pubmed.ncbi.nlm.nih.gov/15588074 DMZT8LI DI DMZT8LI DMZT8LI DN WAY170523 DMZT8LI MI TTHY57M DMZT8LI MN Matrix metalloproteinase-13 (MMP-13) DMZT8LI MT DTT DMZT8LI MA Inhibitor DMZT8LI RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1637). DMZT8LI RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1637 DMNH0CM DI DMNH0CM DMNH0CM DN WAY-196025 DMNH0CM MI TTT1JVS DMNH0CM MN Cytosolic phospholipase A2 (GIVA cPLA2) DMNH0CM MT DTT DMNH0CM MA Inhibitor DMNH0CM RN Reactions of functionalized sulfonamides: application to lowering the lipophilicity of cytosolic phospholipase A2alpha inhibitors. J Med Chem. 2009 Feb 26;52(4):1156-71. DMNH0CM RU https://pubmed.ncbi.nlm.nih.gov/19178292 DMBHXTL DI DMBHXTL DMBHXTL DN WAY200070 DMBHXTL MI TTZAYWL DMBHXTL MN Estrogen receptor (ESR) DMBHXTL MT DTT DMBHXTL MA Inhibitor DMBHXTL RN Design and synthesis of aryl diphenolic azoles as potent and selective estrogen receptor-beta ligands. J Med Chem. 2004 Oct 7;47(21):5021-40. DMBHXTL RU https://pubmed.ncbi.nlm.nih.gov/15456246 DMBHXTL DI DMBHXTL DMBHXTL DN WAY200070 DMBHXTL MI TTOM3J0 DMBHXTL MN Estrogen receptor beta (ESR2) DMBHXTL MT DTT DMBHXTL MA Agonist DMBHXTL RN Design and synthesis of aryl diphenolic azoles as potent and selective estrogen receptor-beta ligands. J Med Chem. 2004 Oct 7;47(21):5021-40. DMBHXTL RU https://pubmed.ncbi.nlm.nih.gov/15456246 DMJ14NE DI DMJ14NE DMJ14NE DN WAY-207024 DMJ14NE MI TT8R70G DMJ14NE MN Gonadotropin-releasing hormone receptor (GNRHR) DMJ14NE MT DTT DMJ14NE MA Inhibitor DMJ14NE RN Synthesis and biological evaluation of piperazinyl heterocyclic antagonists of the gonadotropin releasing hormone (GnRH) receptor. Bioorg Med Chem Lett. 2010 Apr 15;20(8):2512-5. DMJ14NE RU https://pubmed.ncbi.nlm.nih.gov/20236823 DMJ14NE DI DMJ14NE DMJ14NE DN WAY-207024 DMJ14NE MI TTQHJ1K DMJ14NE MN Histamine H2 receptor (H2R) DMJ14NE MT DTT DMJ14NE MA Inhibitor DMJ14NE RN Discovery of 6-({4-[2-(4-tert-butylphenyl)-1H-benzimidazol-4-yl]piperazin-1-yl}methyl)quinoxaline (WAY-207024): an orally active antagonist of the ... J Med Chem. 2009 Apr 9;52(7):2148-52. DMJ14NE RU https://pubmed.ncbi.nlm.nih.gov/19271735 DMJ14NE DI DMJ14NE DMJ14NE DN WAY-207024 DMJ14NE MI TTYO0A3 DMJ14NE MN Substance-K receptor (TACR2) DMJ14NE MT DTT DMJ14NE MA Inhibitor DMJ14NE RN Discovery of 6-({4-[2-(4-tert-butylphenyl)-1H-benzimidazol-4-yl]piperazin-1-yl}methyl)quinoxaline (WAY-207024): an orally active antagonist of the ... J Med Chem. 2009 Apr 9;52(7):2148-52. DMJ14NE RU https://pubmed.ncbi.nlm.nih.gov/19271735 DM9K2LU DI DM9K2LU DM9K2LU DN WAY-208466 DM9K2LU MI TTJQOD7 DM9K2LU MN 5-HT 2A receptor (HTR2A) DM9K2LU MT DTT DM9K2LU MA Inhibitor DM9K2LU RN Novel 1-aminoethyl-3-arylsulfonyl-1H-pyrrolo[2,3-b]pyridines are potent 5-HT(6) agonists. Bioorg Med Chem. 2009 Jul 15;17(14):5153-63. DM9K2LU RU https://pubmed.ncbi.nlm.nih.gov/19523834 DM9K2LU DI DM9K2LU DM9K2LU DN WAY-208466 DM9K2LU MI TTWJBZ5 DM9K2LU MN 5-HT 2C receptor (HTR2C) DM9K2LU MT DTT DM9K2LU MA Inhibitor DM9K2LU RN Novel 1-aminoethyl-3-arylsulfonyl-1H-pyrrolo[2,3-b]pyridines are potent 5-HT(6) agonists. Bioorg Med Chem. 2009 Jul 15;17(14):5153-63. DM9K2LU RU https://pubmed.ncbi.nlm.nih.gov/19523834 DM9K2LU DI DM9K2LU DM9K2LU DN WAY-208466 DM9K2LU MI TTJS8PY DM9K2LU MN 5-HT 6 receptor (HTR6) DM9K2LU MT DTT DM9K2LU MA Inhibitor DM9K2LU RN Novel 1-aminoethyl-3-arylsulfonyl-1H-pyrrolo[2,3-b]pyridines are potent 5-HT(6) agonists. Bioorg Med Chem. 2009 Jul 15;17(14):5153-63. DM9K2LU RU https://pubmed.ncbi.nlm.nih.gov/19523834 DM9K2LU DI DM9K2LU DM9K2LU DN WAY-208466 DM9K2LU MI TTO9X1H DM9K2LU MN 5-HT 7 receptor (HTR7) DM9K2LU MT DTT DM9K2LU MA Inhibitor DM9K2LU RN Novel 1-aminoethyl-3-arylsulfonyl-1H-pyrrolo[2,3-b]pyridines are potent 5-HT(6) agonists. Bioorg Med Chem. 2009 Jul 15;17(14):5153-63. DM9K2LU RU https://pubmed.ncbi.nlm.nih.gov/19523834 DM9K2LU DI DM9K2LU DM9K2LU DN WAY-208466 DM9K2LU MI TTEX248 DM9K2LU MN Dopamine D2 receptor (D2R) DM9K2LU MT DTT DM9K2LU MA Inhibitor DM9K2LU RN Novel 1-aminoethyl-3-arylsulfonyl-1H-pyrrolo[2,3-b]pyridines are potent 5-HT(6) agonists. Bioorg Med Chem. 2009 Jul 15;17(14):5153-63. DM9K2LU RU https://pubmed.ncbi.nlm.nih.gov/19523834 DMMXL4E DI DMMXL4E DMMXL4E DN WAY-213613 DMMXL4E MI TT2F078 DMMXL4E MN Excitatory amino acid transporter 2 (SLC1A2) DMMXL4E MT DTT DMMXL4E MA Inhibitor DMMXL4E RN Characterization of novel aryl-ether, biaryl, and fluorene aspartic acid and diaminopropionic acid analogs as potent inhibitors of the high-affinit... Mol Pharmacol. 2005 Oct;68(4):974-82. DMMXL4E RU https://pubmed.ncbi.nlm.nih.gov/16014807 DM8ODI7 DI DM8ODI7 DM8ODI7 DN WAY-214950 DM8ODI7 MI TTOZRK6 DM8ODI7 MN Glucocorticoid receptor messenger RNA (GCR mRNA) DM8ODI7 MT DTT DM8ODI7 MA Inhibitor DM8ODI7 RN Indazole-based liver X receptor (LXR) modulators with maintained atherosclerotic lesion reduction activity but diminished stimulation of hepatic tr... J Med Chem. 2008 Nov 27;51(22):7161-8. DM8ODI7 RU https://pubmed.ncbi.nlm.nih.gov/18973288 DM8ODI7 DI DM8ODI7 DM8ODI7 DN WAY-214950 DM8ODI7 MI TTECBXN DM8ODI7 MN Oxysterols receptor LXR-alpha (NR1H3) DM8ODI7 MT DTT DM8ODI7 MA Inhibitor DM8ODI7 RN Indazole-based liver X receptor (LXR) modulators with maintained atherosclerotic lesion reduction activity but diminished stimulation of hepatic tr... J Med Chem. 2008 Nov 27;51(22):7161-8. DM8ODI7 RU https://pubmed.ncbi.nlm.nih.gov/18973288 DM8ODI7 DI DM8ODI7 DM8ODI7 DN WAY-214950 DM8ODI7 MI TTXA6PH DM8ODI7 MN Oxysterols receptor LXR-beta (NR1H2) DM8ODI7 MT DTT DM8ODI7 MA Inhibitor DM8ODI7 RN Indazole-based liver X receptor (LXR) modulators with maintained atherosclerotic lesion reduction activity but diminished stimulation of hepatic tr... J Med Chem. 2008 Nov 27;51(22):7161-8. DM8ODI7 RU https://pubmed.ncbi.nlm.nih.gov/18973288 DM8ODI7 DI DM8ODI7 DM8ODI7 DN WAY-214950 DM8ODI7 MI TT7LCTF DM8ODI7 MN Pregnane X receptor (NR1I2) DM8ODI7 MT DTT DM8ODI7 MA Inhibitor DM8ODI7 RN Indazole-based liver X receptor (LXR) modulators with maintained atherosclerotic lesion reduction activity but diminished stimulation of hepatic tr... J Med Chem. 2008 Nov 27;51(22):7161-8. DM8ODI7 RU https://pubmed.ncbi.nlm.nih.gov/18973288 DMC83HA DI DMC83HA DMC83HA DN WAY-254011 DMC83HA MI TTECBXN DMC83HA MN Oxysterols receptor LXR-alpha (NR1H3) DMC83HA MT DTT DMC83HA MA Inhibitor DMC83HA RN Discovery and SAR of cinnolines/quinolines as liver X receptor (LXR) agonists with binding selectivity for LXRbeta. Bioorg Med Chem. 2009 May 15;17(10):3519-27. DMC83HA RU https://pubmed.ncbi.nlm.nih.gov/19394832 DMC83HA DI DMC83HA DMC83HA DN WAY-254011 DMC83HA MI TTXA6PH DMC83HA MN Oxysterols receptor LXR-beta (NR1H2) DMC83HA MT DTT DMC83HA MA Inhibitor DMC83HA RN Discovery and SAR of cinnolines/quinolines as liver X receptor (LXR) agonists with binding selectivity for LXRbeta. Bioorg Med Chem. 2009 May 15;17(10):3519-27. DMC83HA RU https://pubmed.ncbi.nlm.nih.gov/19394832 DMSLNWA DI DMSLNWA DMSLNWA DN WAY-255348 DMSLNWA MI TTKPW01 DMSLNWA MN Androgen receptor messenger RNA (AR mRNA) DMSLNWA MT DTT DMSLNWA MA Inhibitor DMSLNWA RN Design, synthesis, and SAR of new pyrrole-oxindole progesterone receptor modulators leading to 5-(7-fluoro-3,3-dimethyl-2-oxo-2,3-dihydro-1H-indol-... J Med Chem. 2008 Mar 27;51(6):1861-73. DMSLNWA RU https://pubmed.ncbi.nlm.nih.gov/18318463 DMSLNWA DI DMSLNWA DMSLNWA DN WAY-255348 DMSLNWA MI TT26PHO DMSLNWA MN Mineralocorticoid receptor (MR) DMSLNWA MT DTT DMSLNWA MA Inhibitor DMSLNWA RN Design, synthesis, and SAR of new pyrrole-oxindole progesterone receptor modulators leading to 5-(7-fluoro-3,3-dimethyl-2-oxo-2,3-dihydro-1H-indol-... J Med Chem. 2008 Mar 27;51(6):1861-73. DMSLNWA RU https://pubmed.ncbi.nlm.nih.gov/18318463 DMSLNWA DI DMSLNWA DMSLNWA DN WAY-255348 DMSLNWA MI TTUV8G9 DMSLNWA MN Progesterone receptor (PGR) DMSLNWA MT DTT DMSLNWA MA Inhibitor DMSLNWA RN Design, synthesis, and SAR of new pyrrole-oxindole progesterone receptor modulators leading to 5-(7-fluoro-3,3-dimethyl-2-oxo-2,3-dihydro-1H-indol-... J Med Chem. 2008 Mar 27;51(6):1861-73. DMSLNWA RU https://pubmed.ncbi.nlm.nih.gov/18318463 DM48MC3 DI DM48MC3 DM48MC3 DN WAY-256805 DM48MC3 MI TTAWNKZ DM48MC3 MN Norepinephrine transporter (NET) DM48MC3 MT DTT DM48MC3 MA Inhibitor DM48MC3 RN Structure-activity relationships of the cycloalkanol ethylamine scaffold: discovery of selective norepinephrine reuptake inhibitors. J Med Chem. 2008 Jul 10;51(13):4038-49. DM48MC3 RU https://pubmed.ncbi.nlm.nih.gov/18557608 DMMOH51 DI DMMOH51 DMMOH51 DN WAY-466 DMMOH51 MI TTSQIFT DMMOH51 MN 5-HT 1A receptor (HTR1A) DMMOH51 MT DTT DMMOH51 MA Inhibitor DMMOH51 RN Discovery of 5-arylsulfonamido-3-(pyrrolidin-2-ylmethyl)-1H-indole derivatives as potent, selective 5-HT6 receptor agonists and antagonists. J Med Chem. 2005 Jan 27;48(2):353-6. DMMOH51 RU https://pubmed.ncbi.nlm.nih.gov/15658848 DMMOH51 DI DMMOH51 DMMOH51 DN WAY-466 DMMOH51 MI TTK8CXU DMMOH51 MN 5-HT 1B receptor (HTR1B) DMMOH51 MT DTT DMMOH51 MA Inhibitor DMMOH51 RN Discovery of 5-arylsulfonamido-3-(pyrrolidin-2-ylmethyl)-1H-indole derivatives as potent, selective 5-HT6 receptor agonists and antagonists. J Med Chem. 2005 Jan 27;48(2):353-6. DMMOH51 RU https://pubmed.ncbi.nlm.nih.gov/15658848 DMMOH51 DI DMMOH51 DMMOH51 DN WAY-466 DMMOH51 MI TT6MSOK DMMOH51 MN 5-HT 1D receptor (HTR1D) DMMOH51 MT DTT DMMOH51 MA Inhibitor DMMOH51 RN Discovery of 5-arylsulfonamido-3-(pyrrolidin-2-ylmethyl)-1H-indole derivatives as potent, selective 5-HT6 receptor agonists and antagonists. J Med Chem. 2005 Jan 27;48(2):353-6. DMMOH51 RU https://pubmed.ncbi.nlm.nih.gov/15658848 DMMOH51 DI DMMOH51 DMMOH51 DN WAY-466 DMMOH51 MI TT0MI3F DMMOH51 MN 5-HT 1F receptor (HTR1F) DMMOH51 MT DTT DMMOH51 MA Inhibitor DMMOH51 RN Discovery of 5-arylsulfonamido-3-(pyrrolidin-2-ylmethyl)-1H-indole derivatives as potent, selective 5-HT6 receptor agonists and antagonists. J Med Chem. 2005 Jan 27;48(2):353-6. DMMOH51 RU https://pubmed.ncbi.nlm.nih.gov/15658848 DMMOH51 DI DMMOH51 DMMOH51 DN WAY-466 DMMOH51 MI TTWJBZ5 DMMOH51 MN 5-HT 2C receptor (HTR2C) DMMOH51 MT DTT DMMOH51 MA Inhibitor DMMOH51 RN Discovery of 5-arylsulfonamido-3-(pyrrolidin-2-ylmethyl)-1H-indole derivatives as potent, selective 5-HT6 receptor agonists and antagonists. J Med Chem. 2005 Jan 27;48(2):353-6. DMMOH51 RU https://pubmed.ncbi.nlm.nih.gov/15658848 DMMOH51 DI DMMOH51 DMMOH51 DN WAY-466 DMMOH51 MI TTJS8PY DMMOH51 MN 5-HT 6 receptor (HTR6) DMMOH51 MT DTT DMMOH51 MA Inhibitor DMMOH51 RN Discovery of 5-arylsulfonamido-3-(pyrrolidin-2-ylmethyl)-1H-indole derivatives as potent, selective 5-HT6 receptor agonists and antagonists. J Med Chem. 2005 Jan 27;48(2):353-6. DMMOH51 RU https://pubmed.ncbi.nlm.nih.gov/15658848 DMMOH51 DI DMMOH51 DMMOH51 DN WAY-466 DMMOH51 MI TTO9X1H DMMOH51 MN 5-HT 7 receptor (HTR7) DMMOH51 MT DTT DMMOH51 MA Inhibitor DMMOH51 RN Discovery of 5-arylsulfonamido-3-(pyrrolidin-2-ylmethyl)-1H-indole derivatives as potent, selective 5-HT6 receptor agonists and antagonists. J Med Chem. 2005 Jan 27;48(2):353-6. DMMOH51 RU https://pubmed.ncbi.nlm.nih.gov/15658848 DMNCZEQ DI DMNCZEQ DMNCZEQ DN WAY-644 DMNCZEQ MI TTXZ0KQ DMNCZEQ MN Matrix metalloproteinase-12 (MMP-12) DMNCZEQ MT DTT DMNCZEQ MA Inhibitor DMNCZEQ RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1636). DMNCZEQ RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1636 DME10AL DI DME10AL DME10AL DN WBZ-7 DME10AL MI TTX41N9 DME10AL MN Tyrosine-protein kinase Kit (KIT) DME10AL MT DTT DME10AL MA Inhibitor DME10AL RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1805). DME10AL RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1805 DMWU5PK DI DMWU5PK DMWU5PK DN WDuo3 DMWU5PK MI TTOXS3C DMWU5PK MN Muscarinic acetylcholine receptor (CHRM) DMWU5PK MT DTT DMWU5PK MA Modulator (allosteric modulator) DMWU5PK RN Interactions of orthosteric and allosteric ligands with [3H]dimethyl-W84 at the common allosteric site of muscarinic M2 receptors. Mol Pharmacol. 2003 Jul;64(1):180-90. DMWU5PK RU https://pubmed.ncbi.nlm.nih.gov/12815174 DMHL3YV DI DMHL3YV DMHL3YV DN WEDELOLACTONE DMHL3YV MI TTNJYV2 DMHL3YV MN Gamma-aminobutyric acid receptor (GAR) DMHL3YV MT DTT DMHL3YV MA Inhibitor DMHL3YV RN Synthesis and preliminary pharmacological evaluation of coumestans with different patterns of oxygenation. Bioorg Med Chem Lett. 2001 Feb 12;11(3):283-6. DMHL3YV RU https://pubmed.ncbi.nlm.nih.gov/11212092 DMK0OVE DI DMK0OVE DMK0OVE DN WEHI-0103122 DMK0OVE MI TTU1E82 DMK0OVE MN Apoptosis regulator Bcl-xL (BCL-xL) DMK0OVE MT DTT DMK0OVE MA Inhibitor DMK0OVE RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2845). DMK0OVE RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2845 DMAXOIS DI DMAXOIS DMAXOIS DN W-F-F-N--Y-Y-W DMAXOIS MI TTKRD0G DMAXOIS MN Endothelin A receptor (EDNRA) DMAXOIS MT DTT DMAXOIS MA Inhibitor DMAXOIS RN Res-701-1, synthesis and a reevaluation of its effects on the endothelin receptors, Bioorg. Med. Chem. Lett. 5(6):621-626 (1995). DMAXOIS RU http://www.sciencedirect.com/science/article/pii/0960894X95000847 DMAXOIS DI DMAXOIS DMAXOIS DN W-F-F-N--Y-Y-W DMAXOIS MI TT3ZTGU DMAXOIS MN Endothelin B receptor (EDNRB) DMAXOIS MT DTT DMAXOIS MA Inhibitor DMAXOIS RN Res-701-1, synthesis and a reevaluation of its effects on the endothelin receptors, Bioorg. Med. Chem. Lett. 5(6):621-626 (1995). DMAXOIS RU http://www.sciencedirect.com/science/article/pii/0960894X95000847 DMQS7BT DI DMQS7BT DMQS7BT DN WFwGG-NH2 DMQS7BT MI TTWDC17 DMQS7BT MN Growth hormone secretagogue receptor 1 (GHSR) DMQS7BT MT DTT DMQS7BT MA Inhibitor DMQS7BT RN Identification of an efficacy switch region in the ghrelin receptor responsible for interchange between agonism and inverse agonism. J Biol Chem. 2007 May 25;282(21):15799-811. DMQS7BT RU https://pubmed.ncbi.nlm.nih.gov/17371869 DMOBXVL DI DMOBXVL DMOBXVL DN WFwLL-NH2 DMOBXVL MI TTWDC17 DMOBXVL MN Growth hormone secretagogue receptor 1 (GHSR) DMOBXVL MT DTT DMOBXVL MA Inhibitor DMOBXVL RN Identification of an efficacy switch region in the ghrelin receptor responsible for interchange between agonism and inverse agonism. J Biol Chem. 2007 May 25;282(21):15799-811. DMOBXVL RU https://pubmed.ncbi.nlm.nih.gov/17371869 DMJS8VQ DI DMJS8VQ DMJS8VQ DN WH-4-023 DMJS8VQ MI TT860QF DMJS8VQ MN LCK tyrosine protein kinase (LCK) DMJS8VQ MT DTT DMJS8VQ MA Inhibitor DMJS8VQ RN Novel 2-aminopyrimidine carbamates as potent and orally active inhibitors of Lck: synthesis, SAR, and in vivo antiinflammatory activity. J Med Chem. 2006 Aug 10;49(16):4981-91. DMJS8VQ RU https://pubmed.ncbi.nlm.nih.gov/16884310 DMJS8VQ DI DMJS8VQ DMJS8VQ DN WH-4-023 DMJS8VQ MI TT6PKBN DMJS8VQ MN Proto-oncogene c-Src (SRC) DMJS8VQ MT DTT DMJS8VQ MA Inhibitor DMJS8VQ RN Novel 2-aminopyrimidine carbamates as potent and orally active inhibitors of Lck: synthesis, SAR, and in vivo antiinflammatory activity. J Med Chem. 2006 Aug 10;49(16):4981-91. DMJS8VQ RU https://pubmed.ncbi.nlm.nih.gov/16884310 DMYHWS1 DI DMYHWS1 DMYHWS1 DN WHI-P154 DMYHWS1 MI TTGKNB4 DMYHWS1 MN Epidermal growth factor receptor (EGFR) DMYHWS1 MT DTT DMYHWS1 MA Inhibitor DMYHWS1 RN The specificity of JAK3 kinase inhibitors. Blood. 2008 Feb 15;111(4):2155-7. DMYHWS1 RU https://pubmed.ncbi.nlm.nih.gov/18094329 DMYHWS1 DI DMYHWS1 DMYHWS1 DN WHI-P154 DMYHWS1 MI TT6DM01 DMYHWS1 MN Janus kinase 1 (JAK-1) DMYHWS1 MT DTT DMYHWS1 MA Inhibitor DMYHWS1 RN The specificity of JAK3 kinase inhibitors. Blood. 2008 Feb 15;111(4):2155-7. DMYHWS1 RU https://pubmed.ncbi.nlm.nih.gov/18094329 DMYHWS1 DI DMYHWS1 DMYHWS1 DN WHI-P154 DMYHWS1 MI TTRMX3V DMYHWS1 MN Janus kinase 2 (JAK-2) DMYHWS1 MT DTT DMYHWS1 MA Inhibitor DMYHWS1 RN The specificity of JAK3 kinase inhibitors. Blood. 2008 Feb 15;111(4):2155-7. DMYHWS1 RU https://pubmed.ncbi.nlm.nih.gov/18094329 DMYHWS1 DI DMYHWS1 DMYHWS1 DN WHI-P154 DMYHWS1 MI TTT7PJU DMYHWS1 MN Janus kinase 3 (JAK-3) DMYHWS1 MT DTT DMYHWS1 MA Inhibitor DMYHWS1 RN The specificity of JAK3 kinase inhibitors. Blood. 2008 Feb 15;111(4):2155-7. DMYHWS1 RU https://pubmed.ncbi.nlm.nih.gov/18094329 DMZ703W DI DMZ703W DMZ703W DN WilVent DMZ703W MI TTP4520 DMZ703W MN TGF-beta receptor type I (TGFBR1) DMZ703W MT DTT DMZ703W MA Modulator DMZ703W RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1788). DMZ703W RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1788 DMY5LOB DI DMY5LOB DMY5LOB DN WIN 51,708 DMY5LOB MI TTOXS3C DMY5LOB MN Muscarinic acetylcholine receptor (CHRM) DMY5LOB MT DTT DMY5LOB MA Modulator (allosteric modulator) DMY5LOB RN Analogs of WIN 62,577 define a second allosteric site on muscarinic receptors. Mol Pharmacol. 2002 Dec;62(6):1492-505. DMY5LOB RU https://pubmed.ncbi.nlm.nih.gov/12435818 DMY5LOB DI DMY5LOB DMY5LOB DN WIN 51,708 DMY5LOB MI TTQ13Z5 DMY5LOB MN Muscarinic acetylcholine receptor M3 (CHRM3) DMY5LOB MT DTT DMY5LOB MA Modulator (allosteric modulator) DMY5LOB RN Analogs of WIN 62,577 define a second allosteric site on muscarinic receptors. Mol Pharmacol. 2002 Dec;62(6):1492-505. DMY5LOB RU https://pubmed.ncbi.nlm.nih.gov/12435818 DMGOQY2 DI DMGOQY2 DMGOQY2 DN WIN 62,577 DMGOQY2 MI TTOXS3C DMGOQY2 MN Muscarinic acetylcholine receptor (CHRM) DMGOQY2 MT DTT DMGOQY2 MA Modulator (allosteric modulator) DMGOQY2 RN Analogs of WIN 62,577 define a second allosteric site on muscarinic receptors. Mol Pharmacol. 2002 Dec;62(6):1492-505. DMGOQY2 RU https://pubmed.ncbi.nlm.nih.gov/12435818 DMGOQY2 DI DMGOQY2 DMGOQY2 DN WIN 62,577 DMGOQY2 MI TTQ13Z5 DMGOQY2 MN Muscarinic acetylcholine receptor M3 (CHRM3) DMGOQY2 MT DTT DMGOQY2 MA Modulator (allosteric modulator) DMGOQY2 RN Analogs of WIN 62,577 define a second allosteric site on muscarinic receptors. Mol Pharmacol. 2002 Dec;62(6):1492-505. DMGOQY2 RU https://pubmed.ncbi.nlm.nih.gov/12435818 DMTE0YJ DI DMTE0YJ DMTE0YJ DN WIN 64338 DMTE0YJ MI TTGY8IW DMTE0YJ MN B2 bradykinin receptor (BDKRB2) DMTE0YJ MT DTT DMTE0YJ MA Antagonist DMTE0YJ RN Design of potent non-peptide competitive antagonists of the human bradykinin B2 receptor. J Med Chem. 1993 Aug 20;36(17):2583-4. DMTE0YJ RU https://pubmed.ncbi.nlm.nih.gov/8394936 DM6IH4F DI DM6IH4F DM6IH4F DN WIN-35065 DM6IH4F MI TTVBI8W DM6IH4F MN Dopamine transporter (DAT) DM6IH4F MT DTT DM6IH4F MA Inhibitor DM6IH4F RN Synthesis, monoamine transporter binding, properties, and functional monoamine uptake activity of 3beta-[4-methylphenyl and 4-chlorophenyl]-2 beta-... J Med Chem. 2007 Jul 26;50(15):3686-95. DM6IH4F RU https://pubmed.ncbi.nlm.nih.gov/17602602 DM6IH4F DI DM6IH4F DM6IH4F DN WIN-35065 DM6IH4F MI TT3ROYC DM6IH4F MN Serotonin transporter (SERT) DM6IH4F MT DTT DM6IH4F MA Inhibitor DM6IH4F RN Synthesis, monoamine transporter binding, properties, and functional monoamine uptake activity of 3beta-[4-methylphenyl and 4-chlorophenyl]-2 beta-... J Med Chem. 2007 Jul 26;50(15):3686-95. DM6IH4F RU https://pubmed.ncbi.nlm.nih.gov/17602602 DMOX1S0 DI DMOX1S0 DMOX1S0 DN WIN-35066-2 DMOX1S0 MI TTVBI8W DMOX1S0 MN Dopamine transporter (DAT) DMOX1S0 MT DTT DMOX1S0 MA Inhibitor DMOX1S0 RN Monoamine transporter binding, locomotor activity, and drug discrimination properties of 3-(4-substituted-phenyl)tropane-2-carboxylic acid methyl e... J Med Chem. 2004 Dec 2;47(25):6401-9. DMOX1S0 RU https://pubmed.ncbi.nlm.nih.gov/15566309 DMOX1S0 DI DMOX1S0 DMOX1S0 DN WIN-35066-2 DMOX1S0 MI TTAWNKZ DMOX1S0 MN Norepinephrine transporter (NET) DMOX1S0 MT DTT DMOX1S0 MA Inhibitor DMOX1S0 RN Monoamine transporter binding, locomotor activity, and drug discrimination properties of 3-(4-substituted-phenyl)tropane-2-carboxylic acid methyl e... J Med Chem. 2004 Dec 2;47(25):6401-9. DMOX1S0 RU https://pubmed.ncbi.nlm.nih.gov/15566309 DMOX1S0 DI DMOX1S0 DMOX1S0 DN WIN-35066-2 DMOX1S0 MI TT3ROYC DMOX1S0 MN Serotonin transporter (SERT) DMOX1S0 MT DTT DMOX1S0 MA Inhibitor DMOX1S0 RN Monoamine transporter binding, locomotor activity, and drug discrimination properties of 3-(4-substituted-phenyl)tropane-2-carboxylic acid methyl e... J Med Chem. 2004 Dec 2;47(25):6401-9. DMOX1S0 RU https://pubmed.ncbi.nlm.nih.gov/15566309 DMNM50K DI DMNM50K DMNM50K DN WIN-63395 DMNM50K MI TTPLTSQ DMNM50K MN Neutrophil elastase (NE) DMNM50K MT DTT DMNM50K MA Inhibitor DMNM50K RN A comparative SAR and computer modeling study of benzisothiazolone, mechanism-based inhibitors with porcine pancreatic and human leukocyte elastase, Bioorg. Med. Chem. Lett. 6(24):2941-2946 (1996). DMNM50K RU http://www.sciencedirect.com/science/article/pii/S0960894X96005537 DMQ1B2Y DI DMQ1B2Y DMQ1B2Y DN WIN-64745 DMQ1B2Y MI TTZPO1L DMQ1B2Y MN Substance-P receptor (TACR1) DMQ1B2Y MT DTT DMQ1B2Y MA Modulator DMQ1B2Y RN DOI: 10.1021/jo00074a031 DMQ1B2Y RU http://pubs.acs.org/doi/abs/10.1021/jo00074a031 DMUM5LV DI DMUM5LV DMUM5LV DN WIN-66306 DMUM5LV MI TTZPO1L DMUM5LV MN Substance-P receptor (TACR1) DMUM5LV MT DTT DMUM5LV MA Modulator DMUM5LV RN WIN 66306, a new neurokinin antagonist produced by an Aspergillus species: fermentation, isolation and physico-chemical properties. J Antibiot (Tokyo). 1994 Nov;47(11):1182-7. DMUM5LV RU https://www.ncbi.nlm.nih.gov/pubmed/7528191 DMJHG1O DI DMJHG1O DMJHG1O DN WIN-68577 DMJHG1O MI TTZPO1L DMJHG1O MN Substance-P receptor (TACR1) DMJHG1O MT DTT DMJHG1O MA Modulator DMJHG1O RN WIN 66306, a new neurokinin antagonist produced by an Aspergillus species: fermentation, isolation and physico-chemical properties. J Antibiot (Tokyo). 1994 Nov;47(11):1182-7. DMJHG1O RU https://www.ncbi.nlm.nih.gov/pubmed/7528191 DMX0ZBC DI DMX0ZBC DMX0ZBC DN WK-X-34 DMX0ZBC MI TT0JLSD DMX0ZBC MN Multidrug resistance protein (MDR) DMX0ZBC MT DTT DMX0ZBC MA Inhibitor DMX0ZBC RN Thiazolides: a new class of antiviral drugs. Expert Opin Drug Metab Toxicol. 2009 Jun;5(6):667-74. DMX0ZBC RU https://pubmed.ncbi.nlm.nih.gov/19442032 DM8SEHO DI DM8SEHO DM8SEHO DN WL-276 DM8SEHO MI TTJGNVC DM8SEHO MN Apoptosis regulator Bcl-2 (BCL-2) DM8SEHO MT DTT DM8SEHO MA Modulator DM8SEHO RN WL-276, an antagonist against Bcl-2 proteins, overcomes drug resistance and suppresses prostate tumor growth. Cancer Res. 2008 Jun 1;68(11):4377-83. DM8SEHO RU https://pubmed.ncbi.nlm.nih.gov/18519699 DMOZATX DI DMOZATX DMOZATX DN WO2012007375C1 DMOZATX MI TTXAJWN DMOZATX MN IL-1 receptor-associated kinase 1 (IRAK1) DMOZATX MT DTT DMOZATX MA Inhibitor DMOZATX RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2042). DMOZATX RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2042 DMOZATX DI DMOZATX DMOZATX DN WO2012007375C1 DMOZATX MI TTKFVXR DMOZATX MN Renal carcinoma antigen NY-REN-64 (IRAK-4) DMOZATX MT DTT DMOZATX MA Inhibitor DMOZATX RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2045). DMOZATX RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2045 DMPI2MA DI DMPI2MA DMPI2MA DN WO2012007375C7 DMPI2MA MI TTXAJWN DMPI2MA MN IL-1 receptor-associated kinase 1 (IRAK1) DMPI2MA MT DTT DMPI2MA MA Inhibitor DMPI2MA RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2042). DMPI2MA RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2042 DMPI2MA DI DMPI2MA DMPI2MA DN WO2012007375C7 DMPI2MA MI TTKFVXR DMPI2MA MN Renal carcinoma antigen NY-REN-64 (IRAK-4) DMPI2MA MT DTT DMPI2MA MA Inhibitor DMPI2MA RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2045). DMPI2MA RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2045 DM21WOP DI DM21WOP DM21WOP DN WO2013026806C72 DM21WOP MI TTSBVFO DM21WOP MN Dual-specificity tyrosine-phosphorylation regulated kinase 1A (DYRK1A) DM21WOP MT DTT DM21WOP MA Inhibitor DM21WOP RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2009). DM21WOP RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2009 DM21WOP DI DM21WOP DM21WOP DN WO2013026806C72 DM21WOP MI TTYGQ8A DM21WOP MN Dual-specificity tyrosine-phosphorylation regulated kinase 1B (DYRK1B) DM21WOP MT DTT DM21WOP MA Inhibitor DM21WOP RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2010). DM21WOP RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2010 DMDPN4E DI DMDPN4E DMDPN4E DN WO2013110309CA127 DMDPN4E MI TT9U4EP DMDPN4E MN Eukaryotic translation initiation factor 2-alpha kinase 4 (EIF2AK4) DMDPN4E MT DTT DMDPN4E MA Inhibitor DMDPN4E RN Triazolo[4,5-d]pyrimidine Derivatives as Inhibitors of GCN2. ACS Med Chem Lett. 2014 Feb 12;5(4):282-3. DMDPN4E RU https://pubmed.ncbi.nlm.nih.gov/24900825 DMGCF51 DI DMGCF51 DMGCF51 DN Wogonin DMGCF51 MI TTVKILB DMGCF51 MN Prostaglandin G/H synthase 2 (COX-2) DMGCF51 MT DTT DMGCF51 MA Inhibitor DMGCF51 RN Inhibitory activity of prostaglandin E2 production by the synthetic 2'-hydroxychalcone analogues: Synthesis and SAR study. Bioorg Med Chem Lett. 2009 Mar 15;19(6):1650-3. DMGCF51 RU https://pubmed.ncbi.nlm.nih.gov/19233646 DMGCF51 DI DMGCF51 DMGCF51 DN Wogonin DMGCF51 MI TT7RJY8 DMGCF51 MN Xanthine dehydrogenase/oxidase (XDH) DMGCF51 MT DTT DMGCF51 MA Inhibitor DMGCF51 RN Inhibition of cow's milk xanthine oxidase by flavonoids. J Nat Prod. 1988 Mar-Apr;51(2):345-8. DMGCF51 RU https://pubmed.ncbi.nlm.nih.gov/3379415 DMUCGK8 DI DMUCGK8 DMUCGK8 DN WR-080539 DMUCGK8 MI TTSFWA7 DMUCGK8 MN Plasmodium CDK Pfmrk (Malaria Pfmrk) DMUCGK8 MT DTT DMUCGK8 MA Inhibitor DMUCGK8 RN Selective inhibition of Pfmrk, a Plasmodium falciparum CDK, by antimalarial 1,3-diaryl-2-propenones. Bioorg Med Chem Lett. 2009 Apr 1;19(7):1982-5. DMUCGK8 RU https://pubmed.ncbi.nlm.nih.gov/19250824 DMT9WPJ DI DMT9WPJ DMT9WPJ DN WR-089120 DMT9WPJ MI TTSFWA7 DMT9WPJ MN Plasmodium CDK Pfmrk (Malaria Pfmrk) DMT9WPJ MT DTT DMT9WPJ MA Inhibitor DMT9WPJ RN Selective inhibition of Pfmrk, a Plasmodium falciparum CDK, by antimalarial 1,3-diaryl-2-propenones. Bioorg Med Chem Lett. 2009 Apr 1;19(7):1982-5. DMT9WPJ RU https://pubmed.ncbi.nlm.nih.gov/19250824 DM3TI6L DI DM3TI6L DM3TI6L DN WR-190706 DM3TI6L MI TTSFWA7 DM3TI6L MN Plasmodium CDK Pfmrk (Malaria Pfmrk) DM3TI6L MT DTT DM3TI6L MA Inhibitor DM3TI6L RN Selective inhibition of Pfmrk, a Plasmodium falciparum CDK, by antimalarial 1,3-diaryl-2-propenones. Bioorg Med Chem Lett. 2009 Apr 1;19(7):1982-5. DM3TI6L RU https://pubmed.ncbi.nlm.nih.gov/19250824 DM9M1UO DI DM9M1UO DM9M1UO DN WR-203581 DM9M1UO MI TTSFWA7 DM9M1UO MN Plasmodium CDK Pfmrk (Malaria Pfmrk) DM9M1UO MT DTT DM9M1UO MA Inhibitor DM9M1UO RN Selective inhibition of Pfmrk, a Plasmodium falciparum CDK, by antimalarial 1,3-diaryl-2-propenones. Bioorg Med Chem Lett. 2009 Apr 1;19(7):1982-5. DM9M1UO RU https://pubmed.ncbi.nlm.nih.gov/19250824 DM5W9GR DI DM5W9GR DM5W9GR DN WR-289009 DM5W9GR MI TTSFWA7 DM5W9GR MN Plasmodium CDK Pfmrk (Malaria Pfmrk) DM5W9GR MT DTT DM5W9GR MA Inhibitor DM5W9GR RN Selective inhibition of Pfmrk, a Plasmodium falciparum CDK, by antimalarial 1,3-diaryl-2-propenones. Bioorg Med Chem Lett. 2009 Apr 1;19(7):1982-5. DM5W9GR RU https://pubmed.ncbi.nlm.nih.gov/19250824 DMS2QUL DI DMS2QUL DMS2QUL DN WR-289010 DMS2QUL MI TTSFWA7 DMS2QUL MN Plasmodium CDK Pfmrk (Malaria Pfmrk) DMS2QUL MT DTT DMS2QUL MA Inhibitor DMS2QUL RN Selective inhibition of Pfmrk, a Plasmodium falciparum CDK, by antimalarial 1,3-diaryl-2-propenones. Bioorg Med Chem Lett. 2009 Apr 1;19(7):1982-5. DMS2QUL RU https://pubmed.ncbi.nlm.nih.gov/19250824 DMG2LVM DI DMG2LVM DMG2LVM DN WR-289012 DMG2LVM MI TTSFWA7 DMG2LVM MN Plasmodium CDK Pfmrk (Malaria Pfmrk) DMG2LVM MT DTT DMG2LVM MA Inhibitor DMG2LVM RN Selective inhibition of Pfmrk, a Plasmodium falciparum CDK, by antimalarial 1,3-diaryl-2-propenones. Bioorg Med Chem Lett. 2009 Apr 1;19(7):1982-5. DMG2LVM RU https://pubmed.ncbi.nlm.nih.gov/19250824 DMT08ZH DI DMT08ZH DMT08ZH DN WR-289016 DMT08ZH MI TTSFWA7 DMT08ZH MN Plasmodium CDK Pfmrk (Malaria Pfmrk) DMT08ZH MT DTT DMT08ZH MA Inhibitor DMT08ZH RN Selective inhibition of Pfmrk, a Plasmodium falciparum CDK, by antimalarial 1,3-diaryl-2-propenones. Bioorg Med Chem Lett. 2009 Apr 1;19(7):1982-5. DMT08ZH RU https://pubmed.ncbi.nlm.nih.gov/19250824 DM9V0KP DI DM9V0KP DM9V0KP DN WR85915 DM9V0KP MI TTML2WA DM9V0KP MN Tubulin (TUB) DM9V0KP MT DTT DM9V0KP MA Inhibitor DM9V0KP RN Cellular effects of leishmanial tubulin inhibitors on L. donovani. Mol Biochem Parasitol. 2000 Oct;110(2):223-36. DM9V0KP RU https://pubmed.ncbi.nlm.nih.gov/11071278 DM1U29V DI DM1U29V DM1U29V DN WRC-0571 DM1U29V MI TTK25J1 DM1U29V MN Adenosine A1 receptor (ADORA1) DM1U29V MT DTT DM1U29V MA Antagonist DM1U29V RN Characterization of 8-(N-methylisopropyl)amino-N6-(5'-endohydroxy- endonorbornyl)-9-methyladenine (WRC-0571), a highly potent and selective, non-xanthine antagonist of A1 adenosine receptors. J Pharmacol Exp Ther. 1996 Feb;276(2):490-9. DM1U29V RU https://pubmed.ncbi.nlm.nih.gov/8632314 DMP761U DI DMP761U DMP761U DN WRR-112 DMP761U MI TTJOKD1 DMP761U MN Cathepsin F (CTSF) DMP761U MT DTT DMP761U MA Inhibitor DMP761U RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMP761U RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMP761U DI DMP761U DMP761U DN WRR-112 DMP761U MI TTEAID7 DMP761U MN Trypanosoma Cruzipain (Trypano CYSP) DMP761U MT DTT DMP761U MA Inhibitor DMP761U RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMP761U RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMRVAH1 DI DMRVAH1 DMRVAH1 DN WRR-204 DMRVAH1 MI TTEAID7 DMRVAH1 MN Trypanosoma Cruzipain (Trypano CYSP) DMRVAH1 MT DTT DMRVAH1 MA Inhibitor DMRVAH1 RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DMRVAH1 RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMPYGMO DI DMPYGMO DMPYGMO DN WRR605 DMPYGMO MI TTPXTVS DMPYGMO MN Entamoeba Cysteine proteinase CP4 (Eh CP4) DMPYGMO MT DTT DMPYGMO MA Inhibitor DMPYGMO RN A novel Entamoeba histolytica cysteine proteinase, EhCP4, is key for invasive amebiasis and a therapeutic target. J Biol Chem. 2010 Jun 11;285(24):18516-27. DMPYGMO RU https://pubmed.ncbi.nlm.nih.gov/20378535 DM8ZA6K DI DM8ZA6K DM8ZA6K DN WRR-99 DM8ZA6K MI TTJOKD1 DM8ZA6K MN Cathepsin F (CTSF) DM8ZA6K MT DTT DM8ZA6K MA Inhibitor DM8ZA6K RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DM8ZA6K RU https://pubmed.ncbi.nlm.nih.gov/17139284 DM8ZA6K DI DM8ZA6K DM8ZA6K DN WRR-99 DM8ZA6K MI TTEAID7 DM8ZA6K MN Trypanosoma Cruzipain (Trypano CYSP) DM8ZA6K MT DTT DM8ZA6K MA Inhibitor DM8ZA6K RN How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. DM8ZA6K RU https://pubmed.ncbi.nlm.nih.gov/17139284 DMYNIG5 DI DMYNIG5 DMYNIG5 DN WS-070117 DMYNIG5 MI TTOF3WZ DMYNIG5 MN Lipoprotein lipase (LPL) DMYNIG5 MT DTT DMYNIG5 MA Modulator DMYNIG5 RN Alipogene tiparvovec for the treatment of lipoprotein lipase deficiency. Drugs Today (Barc). 2013 Mar;49(3):161-70. DMYNIG5 RU https://pubmed.ncbi.nlm.nih.gov/23527320 DM48MHL DI DM48MHL DM48MHL DN WS-12 DM48MHL MI TTXDKTO DM48MHL MN Long transient receptor potential channel 8 (TRPM8) DM48MHL MT DTT DM48MHL MA Activator DM48MHL RN Characterization of selective TRPM8 ligands and their structure activity response (S.A.R) relationship. J Pharm Pharm Sci. 2010;13(2):242-53. DM48MHL RU https://pubmed.ncbi.nlm.nih.gov/20816009 DMT5SXR DI DMT5SXR DMT5SXR DN WS-23 DMT5SXR MI TTXDKTO DMT5SXR MN Long transient receptor potential channel 8 (TRPM8) DMT5SXR MT DTT DMT5SXR MA Activator DMT5SXR RN Characterization of the mouse cold-menthol receptor TRPM8 and vanilloid receptor type-1 VR1 using a fluorometric imaging plate reader (FLIPR) assay. Br J Pharmacol. 2004 Feb;141(4):737-45. DMT5SXR RU https://pubmed.ncbi.nlm.nih.gov/14757700 DM1R8MW DI DM1R8MW DM1R8MW DN WS-3 DM1R8MW MI TTXDKTO DM1R8MW MN Long transient receptor potential channel 8 (TRPM8) DM1R8MW MT DTT DM1R8MW MA Activator DM1R8MW RN Characterization of the mouse cold-menthol receptor TRPM8 and vanilloid receptor type-1 VR1 using a fluorometric imaging plate reader (FLIPR) assay. Br J Pharmacol. 2004 Feb;141(4):737-45. DM1R8MW RU https://pubmed.ncbi.nlm.nih.gov/14757700 DMX1JR0 DI DMX1JR0 DMX1JR0 DN WS-5 DMX1JR0 MI TTXDKTO DMX1JR0 MN Long transient receptor potential channel 8 (TRPM8) DMX1JR0 MT DTT DMX1JR0 MA Activator DMX1JR0 RN Characterization of selective TRPM8 ligands and their structure activity response (S.A.R) relationship. J Pharm Pharm Sci. 2010;13(2):242-53. DMX1JR0 RU https://pubmed.ncbi.nlm.nih.gov/20816009 DM6A08D DI DM6A08D DM6A08D DN WS-50030 DM6A08D MI TTEX248 DM6A08D MN Dopamine D2 receptor (D2R) DM6A08D MT DTT DM6A08D MA Agonist DM6A08D RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 215). DM6A08D RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=215 DMF9SOV DI DMF9SOV DMF9SOV DN WTLNSAGYLL-CONH2 DMF9SOV MI TTX3HNZ DMF9SOV MN Galanin receptor type 1 (GAL1-R) DMF9SOV MT DTT DMF9SOV MA Inhibitor DMF9SOV RN Engineering galanin analogues that discriminate between GalR1 and GalR2 receptor subtypes and exhibit anticonvulsant activity following systemic de... J Med Chem. 2010 Feb 25;53(4):1871-5. DMF9SOV RU https://pubmed.ncbi.nlm.nih.gov/20121116 DMF9SOV DI DMF9SOV DMF9SOV DN WTLNSAGYLL-CONH2 DMF9SOV MI TTBPW3J DMF9SOV MN Galanin receptor type 2 (GAL2-R) DMF9SOV MT DTT DMF9SOV MA Inhibitor DMF9SOV RN Engineering galanin analogues that discriminate between GalR1 and GalR2 receptor subtypes and exhibit anticonvulsant activity following systemic de... J Med Chem. 2010 Feb 25;53(4):1871-5. DMF9SOV RU https://pubmed.ncbi.nlm.nih.gov/20121116 DMB3567 DI DMB3567 DMB3567 DN WTLNSAGYLLGPHAVGNHPSFSDKNGLTS-CONH2 DMB3567 MI TTX3HNZ DMB3567 MN Galanin receptor type 1 (GAL1-R) DMB3567 MT DTT DMB3567 MA Inhibitor DMB3567 RN Engineering galanin analogues that discriminate between GalR1 and GalR2 receptor subtypes and exhibit anticonvulsant activity following systemic de... J Med Chem. 2010 Feb 25;53(4):1871-5. DMB3567 RU https://pubmed.ncbi.nlm.nih.gov/20121116 DMB3567 DI DMB3567 DMB3567 DN WTLNSAGYLLGPHAVGNHPSFSDKNGLTS-CONH2 DMB3567 MI TTBPW3J DMB3567 MN Galanin receptor type 2 (GAL2-R) DMB3567 MT DTT DMB3567 MA Inhibitor DMB3567 RN Engineering galanin analogues that discriminate between GalR1 and GalR2 receptor subtypes and exhibit anticonvulsant activity following systemic de... J Med Chem. 2010 Feb 25;53(4):1871-5. DMB3567 RU https://pubmed.ncbi.nlm.nih.gov/20121116 DMVZB8U DI DMVZB8U DMVZB8U DN WVTHRLAGLLSRSGGVVKNNFVPTNVGSKAF-NH2 DMVZB8U MI TTVSFJW DMVZB8U MN Calcitonin gene-related peptide 1 (CALCA) DMVZB8U MT DTT DMVZB8U MA Inhibitor DMVZB8U RN Identification of potent, selective, and metabolically stable peptide antagonists to the calcitonin gene-related peptide (CGRP) receptor. J Med Chem. 2008 Dec 25;51(24):7889-97. DMVZB8U RU https://pubmed.ncbi.nlm.nih.gov/19053766 DM6J7OQ DI DM6J7OQ DM6J7OQ DN WX-037 DM6J7OQ MI TTHBTOP DM6J7OQ MN PI3-kinase gamma (PIK3CG) DM6J7OQ MT DTT DM6J7OQ MA Inhibitor DM6J7OQ RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2155). DM6J7OQ RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2155 DM0AZLE DI DM0AZLE DM0AZLE DN WY-46016 DM0AZLE MI TTGKOY9 DM0AZLE MN Leukotriene CysLT1 receptor (CYSLTR1) DM0AZLE MT DTT DM0AZLE MA Modulator DM0AZLE RN N-[(arylmethoxy)phenyl] carboxylic acids, hydroxamic acids, tetrazoles, and sulfonyl carboxamides.Potent orally active leukotriene D4 antagonists of novel structure.J Med Chem.1990 Jan;33(1):240-5. DM0AZLE RU https://www.ncbi.nlm.nih.gov/pubmed/2104935 DMBWUR0 DI DMBWUR0 DMBWUR0 DN WZ-3146 DMBWUR0 MI TTGKNB4 DMBWUR0 MN Epidermal growth factor receptor (EGFR) DMBWUR0 MT DTT DMBWUR0 MA Inhibitor DMBWUR0 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1797). DMBWUR0 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1797 DMP9RBK DI DMP9RBK DMP9RBK DN WZ4003 DMP9RBK MI TTHVOTQ DMP9RBK MN NUAK family SNF1-like kinase 2 (NUAK2) DMP9RBK MT DTT DMP9RBK MA Inhibitor DMP9RBK RN Characterization of WZ4003 and HTH-01-015 as selective inhibitors of the LKB1-tumour-suppressor-activated NUAK kinases. Biochem J. 2014 Jan 1;457(1):215-25. DMP9RBK RU https://pubmed.ncbi.nlm.nih.gov/24171924 DMP9RBK DI DMP9RBK DMP9RBK DN WZ4003 DMP9RBK MI TT65FL0 DMP9RBK MN Omphalocele kinase 1 (NUAK1) DMP9RBK MT DTT DMP9RBK MA Inhibitor DMP9RBK RN Characterization of WZ4003 and HTH-01-015 as selective inhibitors of the LKB1-tumour-suppressor-activated NUAK kinases. Biochem J. 2014 Jan 1;457(1):215-25. DMP9RBK RU https://pubmed.ncbi.nlm.nih.gov/24171924 DMZ0TDL DI DMZ0TDL DMZ0TDL DN X-387 DMZ0TDL MI TTCJG29 DMZ0TDL MN Serine/threonine-protein kinase mTOR (mTOR) DMZ0TDL MT DTT DMZ0TDL MA Inhibitor DMZ0TDL RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2109). DMZ0TDL RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2109 DMOVJP3 DI DMOVJP3 DMOVJP3 DN xamoterol DMOVJP3 MI TTMXGCW DMOVJP3 MN Adrenergic receptor beta-3 (ADRB3) DMOVJP3 MT DTT DMOVJP3 MA Agonist DMOVJP3 RN Binding pockets of the beta(1)- and beta(2)-adrenergic receptors for subtype-selective agonists. Mol Pharmacol. 1999 Nov;56(5):875-85. DMOVJP3 RU https://pubmed.ncbi.nlm.nih.gov/10531390 DMGYVFD DI DMGYVFD DMGYVFD DN xanthine amine congener DMGYVFD MI TTK25J1 DMGYVFD MN Adenosine A1 receptor (ADORA1) DMGYVFD MT DTT DMGYVFD MA Antagonist DMGYVFD RN Species difference in the G protein selectivity of the human and bovine A1-adenosine receptor. J Biol Chem. 1994 Dec 23;269(51):32077-84. DMGYVFD RU https://pubmed.ncbi.nlm.nih.gov/7798201 DMGYVFD DI DMGYVFD DMGYVFD DN xanthine amine congener DMGYVFD MI TTNE7KG DMGYVFD MN Adenosine A2b receptor (ADORA2B) DMGYVFD MT DTT DMGYVFD MA Antagonist DMGYVFD RN Use of the triazolotriazine [3H]ZM 241385 as a radioligand at recombinant human A2B adenosine receptors. Drug Des Discov. 1999 Nov;16(3):217-26. DMGYVFD RU https://pubmed.ncbi.nlm.nih.gov/10624567 DMGYVFD DI DMGYVFD DMGYVFD DN xanthine amine congener DMGYVFD MI TTJFY5U DMGYVFD MN Adenosine A3 receptor (ADORA3) DMGYVFD MT DTT DMGYVFD MA Antagonist DMGYVFD RN [(3)H]MRE 3008F20: a novel antagonist radioligand for the pharmacological and biochemical characterization of human A(3) adenosine receptors. Mol Pharmacol. 2000 May;57(5):968-75. DMGYVFD RU https://pubmed.ncbi.nlm.nih.gov/10779381 DM1GJX8 DI DM1GJX8 DM1GJX8 DN Xanthosine-5'-monophosphate disodium salt DM1GJX8 MI TTV7Y40 DM1GJX8 MN Mycobacterium Orotidine phosphate decarboxylase (MycB pyrF) DM1GJX8 MT DTT DM1GJX8 MA Inhibitor DM1GJX8 RN Structural diversity and plasticity associated with nucleotides targeting orotidine monophosphate decarboxylase. J Med Chem. 2008 Feb 14;51(3):432-8. DM1GJX8 RU https://pubmed.ncbi.nlm.nih.gov/18181562 DM38TLN DI DM38TLN DM38TLN DN XANTHOSTIGMINE DM38TLN MI TT1RS9F DM38TLN MN Acetylcholinesterase (AChE) DM38TLN MT DTT DM38TLN MA Inhibitor DM38TLN RN Acetylcholinesterase inhibitors: synthesis and structure-activity relationships of omega-[N-methyl-N-(3-alkylcarbamoyloxyphenyl)- methyl]aminoalkox... J Med Chem. 1998 Oct 8;41(21):3976-86. DM38TLN RU https://pubmed.ncbi.nlm.nih.gov/9767635 DM38TLN DI DM38TLN DM38TLN DN XANTHOSTIGMINE DM38TLN MI TTEB0GD DM38TLN MN Cholinesterase (BCHE) DM38TLN MT DTT DM38TLN MA Inhibitor DM38TLN RN Acetylcholinesterase inhibitors: synthesis and structure-activity relationships of omega-[N-methyl-N-(3-alkylcarbamoyloxyphenyl)- methyl]aminoalkox... J Med Chem. 1998 Oct 8;41(21):3976-86. DM38TLN RU https://pubmed.ncbi.nlm.nih.gov/9767635 DMLTVI6 DI DMLTVI6 DMLTVI6 DN XAP044 DMLTVI6 MI TT0I76D DMLTVI6 MN Metabotropic glutamate receptor 7 (mGluR7) DMLTVI6 MT DTT DMLTVI6 MA Modulator (allosteric modulator) DMLTVI6 RN Blocking metabotropic glutamate receptor subtype 7 (mGlu7) via the Venus flytrap domain (VFTD) inhibits amygdala plasticity, stress, and anxiety-related behavior. J Biol Chem. 2014 Apr 18;289(16):10975-87. DMLTVI6 RU https://pubmed.ncbi.nlm.nih.gov/24596089 DMYT5DI DI DMYT5DI DMYT5DI DN XB-05 DMYT5DI MI TT6S2FE DMYT5DI MN DNA [cytosine-5]-methyltransferase 1 (DNMT1) DMYT5DI MT DTT DMYT5DI MA Inhibitor DMYT5DI RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2605). DMYT5DI RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2605 DMBN7UX DI DMBN7UX DMBN7UX DN XB-387 DMBN7UX MI TTI7421 DMBN7UX MN Platelet-derived growth factor receptor beta (PDGFRB) DMBN7UX MT DTT DMBN7UX RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1804). DMBN7UX RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1804 DM8PADV DI DM8PADV DM8PADV DN XCC DM8PADV MI TTNE7KG DM8PADV MN Adenosine A2b receptor (ADORA2B) DM8PADV MT DTT DM8PADV MA Antagonist DM8PADV RN [3H]MRS 1754, a selective antagonist radioligand for A(2B) adenosine receptors. Biochem Pharmacol. 2001 Mar 15;61(6):657-63. DM8PADV RU https://pubmed.ncbi.nlm.nih.gov/11266650 DMZ7N8D DI DMZ7N8D DMZ7N8D DN XCT790 DMZ7N8D MI TTPNQAC DMZ7N8D MN Estrogen-related receptor-alpha (ESRRA) DMZ7N8D MT DTT DMZ7N8D MA Antagonist DMZ7N8D RN Regulation of PPARgamma coactivator 1alpha (PGC-1alpha) signaling by an estrogen-related receptor alpha (ERRalpha) ligand. Proc Natl Acad Sci U S A. 2004 Jun 15;101(24):8912-7. DMZ7N8D RU https://pubmed.ncbi.nlm.nih.gov/15184675 DMS3TZ5 DI DMS3TZ5 DMS3TZ5 DN XD1 DMS3TZ5 MI TTRA6BO DMS3TZ5 MN Bromodomain-containing protein 4 (BRD4) DMS3TZ5 MT DTT DMS3TZ5 MA Inhibitor DMS3TZ5 RN 4-Acyl pyrroles: mimicking acetylated lysines in histone code reading. Angew Chem Int Ed Engl. 2013 Dec 23;52(52):14055-9. DMS3TZ5 RU https://pubmed.ncbi.nlm.nih.gov/24272870 DMUMACD DI DMUMACD DMUMACD DN XD14 DMUMACD MI TT7CPI5 DMUMACD MN Bromodomain testis-specific protein (BRDT) DMUMACD MT DTT DMUMACD MA Inhibitor DMUMACD RN 4-Acyl pyrroles: mimicking acetylated lysines in histone code reading. Angew Chem Int Ed Engl. 2013 Dec 23;52(52):14055-9. DMUMACD RU https://pubmed.ncbi.nlm.nih.gov/24272870 DMUMACD DI DMUMACD DMUMACD DN XD14 DMUMACD MI TTDP48B DMUMACD MN Bromodomain-containing protein 2 (BRD2) DMUMACD MT DTT DMUMACD MA Inhibitor DMUMACD RN 4-Acyl pyrroles: mimicking acetylated lysines in histone code reading. Angew Chem Int Ed Engl. 2013 Dec 23;52(52):14055-9. DMUMACD RU https://pubmed.ncbi.nlm.nih.gov/24272870 DMUMACD DI DMUMACD DMUMACD DN XD14 DMUMACD MI TTHE657 DMUMACD MN Bromodomain-containing protein 3 (BRD3) DMUMACD MT DTT DMUMACD MA Inhibitor DMUMACD RN 4-Acyl pyrroles: mimicking acetylated lysines in histone code reading. Angew Chem Int Ed Engl. 2013 Dec 23;52(52):14055-9. DMUMACD RU https://pubmed.ncbi.nlm.nih.gov/24272870 DMUMACD DI DMUMACD DMUMACD DN XD14 DMUMACD MI TTRA6BO DMUMACD MN Bromodomain-containing protein 4 (BRD4) DMUMACD MT DTT DMUMACD MA Inhibitor DMUMACD RN 4-Acyl pyrroles: mimicking acetylated lysines in histone code reading. Angew Chem Int Ed Engl. 2013 Dec 23;52(52):14055-9. DMUMACD RU https://pubmed.ncbi.nlm.nih.gov/24272870 DMLH1PK DI DMLH1PK DMLH1PK DN XE991 DMLH1PK MI TT846HF DMLH1PK MN Voltage-gated potassium channel Kv7.1 (KCNQ1) DMLH1PK MT DTT DMLH1PK MA Blocker (channel blocker) DMLH1PK RN Molecular basis for differential sensitivity of KCNQ and I(Ks) channels to the cognitive enhancer XE991. Mol Pharmacol. 2000 Jun;57(6):1218-23. DMLH1PK RU https://pubmed.ncbi.nlm.nih.gov/10825393 DMLH1PK DI DMLH1PK DMLH1PK DN XE991 DMLH1PK MI TTPXI3S DMLH1PK MN Voltage-gated potassium channel Kv7.2 (KCNQ2) DMLH1PK MT DTT DMLH1PK MA Blocker (channel blocker) DMLH1PK RN KCNQ2 and KCNQ3 potassium channel subunits: molecular correlates of the M-channel. Science. 1998 Dec 4;282(5395):1890-3. DMLH1PK RU https://pubmed.ncbi.nlm.nih.gov/9836639 DMLH1PK DI DMLH1PK DMLH1PK DN XE991 DMLH1PK MI TT8HGRW DMLH1PK MN Voltage-gated potassium channel Kv7.4 (KCNQ4) DMLH1PK MT DTT DMLH1PK MA Blocker (channel blocker) DMLH1PK RN KCNQ4 channels expressed in mammalian cells: functional characteristics and pharmacology. Am J Physiol Cell Physiol. 2001 Apr;280(4):C859-66. DMLH1PK RU https://pubmed.ncbi.nlm.nih.gov/11245603 DMLH1PK DI DMLH1PK DMLH1PK DN XE991 DMLH1PK MI TTWVL5Q DMLH1PK MN Voltage-gated potassium channel Kv7.5 (KCNQ5) DMLH1PK MT DTT DMLH1PK MA Blocker (channel blocker) DMLH1PK RN KCNQ5, a novel potassium channel broadly expressed in brain, mediates M-type currents. J Biol Chem. 2000 Aug 4;275(31):24089-95. DMLH1PK RU https://pubmed.ncbi.nlm.nih.gov/10816588 DMZ24P1 DI DMZ24P1 DMZ24P1 DN XEN-907 DMZ24P1 MI TT4G2JS DMZ24P1 MN Voltage-gated sodium channel alpha Nav1.7 (SCN9A) DMZ24P1 MT DTT DMZ24P1 MA Inhibitor DMZ24P1 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 584). DMZ24P1 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=584 DM1EHG5 DI DM1EHG5 DM1EHG5 DN XEN-D0104 DM1EHG5 MI TTW0CMT DM1EHG5 MN Voltage-gated potassium channel Kv1.5 (KCNA5) DM1EHG5 MT DTT DM1EHG5 MA Opener DM1EHG5 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 542). DM1EHG5 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=542 DMAPRNO DI DMAPRNO DMAPRNO DN xenin DMAPRNO MI TT31Q0V DMAPRNO MN Neurotensin receptor type 2 (NTSR2) DMAPRNO MT DTT DMAPRNO MA Agonist DMAPRNO RN Stable expression of the mouse levocabastine-sensitive neurotensin receptor in HEK 293 cell line: binding properties, photoaffinity labeling, and internalization mechanism. Biochem Biophys Res Commun. 1998 Feb 13;243(2):585-90. DMAPRNO RU https://pubmed.ncbi.nlm.nih.gov/9480852 DMVTCZ1 DI DMVTCZ1 DMVTCZ1 DN XEP-018 DMVTCZ1 MI TT84DRB DMVTCZ1 MN Voltage-gated sodium channel alpha Nav1.4 (SCN4A) DMVTCZ1 MT DTT DMVTCZ1 MA Modulator DMVTCZ1 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 581). DMVTCZ1 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=581 DM4YQR2 DI DM4YQR2 DM4YQR2 DN xestospongin C DM4YQR2 MI TT5HWAT DM4YQR2 MN IP3 receptor isoform 1 (ITPR1) DM4YQR2 MT DTT DM4YQR2 MA Antagonist DM4YQR2 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 743). DM4YQR2 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=743 DM96FTS DI DM96FTS DM96FTS DN XGP-110 DM96FTS MI TTVKILB DM96FTS MN Prostaglandin G/H synthase 2 (COX-2) DM96FTS MT DTT DM96FTS MA Inhibitor DM96FTS RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1376). DM96FTS RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1376 DMBLR73 DI DMBLR73 DMBLR73 DN XGP-510 DMBLR73 MI TTGKOY9 DMBLR73 MN Leukotriene CysLT1 receptor (CYSLTR1) DMBLR73 MT DTT DMBLR73 MA Antagonist DMBLR73 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 269). DMBLR73 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=269 DMZIHKY DI DMZIHKY DMZIHKY DN XMD8-92 DMZIHKY MI TTHK3MO DMZIHKY MN Doublecortin-like kinase 2 (DCLK2) DMZIHKY MT DTT DMZIHKY MA Inhibitor DMZIHKY RN Pharmacological inhibition of BMK1 suppresses tumor growth through promyelocytic leukemia protein. Cancer Cell. 2010 Sep 14;18(3):258-67. DMZIHKY RU https://pubmed.ncbi.nlm.nih.gov/20832753 DMZIHKY DI DMZIHKY DMZIHKY DN XMD8-92 DMZIHKY MI TTU6FSC DMZIHKY MN Extracellular signal-regulated kinase 5 (ERK5) DMZIHKY MT DTT DMZIHKY MA Inhibitor DMZIHKY RN Pharmacological inhibition of BMK1 suppresses tumor growth through promyelocytic leukemia protein. Cancer Cell. 2010 Sep 14;18(3):258-67. DMZIHKY RU https://pubmed.ncbi.nlm.nih.gov/20832753 DMZIHKY DI DMZIHKY DMZIHKY DN XMD8-92 DMZIHKY MI TTWS7I3 DMZIHKY MN Non-receptor tyrosine-protein kinase TNK1 (TNK1) DMZIHKY MT DTT DMZIHKY MA Inhibitor DMZIHKY RN Pharmacological inhibition of BMK1 suppresses tumor growth through promyelocytic leukemia protein. Cancer Cell. 2010 Sep 14;18(3):258-67. DMZIHKY RU https://pubmed.ncbi.nlm.nih.gov/20832753 DMZIHKY DI DMZIHKY DMZIHKY DN XMD8-92 DMZIHKY MI TTGPNZQ DMZIHKY MN Polo-like kinase 4 (PLK4) DMZIHKY MT DTT DMZIHKY MA Inhibitor DMZIHKY RN Pharmacological inhibition of BMK1 suppresses tumor growth through promyelocytic leukemia protein. Cancer Cell. 2010 Sep 14;18(3):258-67. DMZIHKY RU https://pubmed.ncbi.nlm.nih.gov/20832753 DMHWTCY DI DMHWTCY DMHWTCY DN XMetD DMHWTCY MI TTCBFJO DMHWTCY MN Insulin receptor (INSR) DMHWTCY MT DTT DMHWTCY RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1800). DMHWTCY RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1800 DM6JKL7 DI DM6JKL7 DM6JKL7 DN XMetS DM6JKL7 MI TTCBFJO DM6JKL7 MN Insulin receptor (INSR) DM6JKL7 MT DTT DM6JKL7 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1800). DM6JKL7 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1800 DM5TR49 DI DM5TR49 DM5TR49 DN XMT-1191 DM5TR49 MI TTZL0OI DM5TR49 MN Methionine aminopeptidase 2 (METAP2) DM5TR49 MT DTT DM5TR49 MA Inhibitor DM5TR49 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1573). DM5TR49 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1573 DMXH6DL DI DMXH6DL DMXH6DL DN XN-0502 DMXH6DL MI TTYFKSZ DMXH6DL MN Tubulin beta (TUBB) DMXH6DL MT DTT DMXH6DL MA Modulator DMXH6DL RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2640). DMXH6DL RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2640 DMPOGXU DI DMPOGXU DMPOGXU DN XNT DMPOGXU MI TTUI5H7 DMPOGXU MN Angiotensin-converting enzyme 2 (ACE2) DMPOGXU MT DTT DMPOGXU MA Activator DMPOGXU RN Structure-based identification of small-molecule angiotensin-converting enzyme 2 activators as novel antihypertensive agents. Hypertension. 2008 May;51(5):1312-7. DMPOGXU RU https://pubmed.ncbi.nlm.nih.gov/18391097 DMGOMYN DI DMGOMYN DMGOMYN DN XP-21510 DMGOMYN MI TTP86E2 DMGOMYN MN Plasminogen (PLG) DMGOMYN MT DTT DMGOMYN MA Inhibitor DMGOMYN RN Tranexamic acid in trauma: how should we use it. J Trauma Acute Care Surg. 2013 Jun;74(6):1575-86. DMGOMYN RU https://pubmed.ncbi.nlm.nih.gov/23694890 DMTUFI1 DI DMTUFI1 DMTUFI1 DN XR-9456 DMTUFI1 MI TT3OT40 DMTUFI1 MN Multidrug resistance protein 1 (ABCB1) DMTUFI1 MT DTT DMTUFI1 MA Inhibitor DMTUFI1 RN Functional assay and structure-activity relationships of new third-generation P-glycoprotein inhibitors. Bioorg Med Chem. 2008 Mar 1;16(5):2448-62. DMTUFI1 RU https://pubmed.ncbi.nlm.nih.gov/18083034 DMTUFI1 DI DMTUFI1 DMTUFI1 DN XR-9456 DMTUFI1 MI TTOI92F DMTUFI1 MN Multidrug resistance-associated protein 1 (ABCC1) DMTUFI1 MT DTT DMTUFI1 MA Inhibitor DMTUFI1 RN Functional assay and structure-activity relationships of new third-generation P-glycoprotein inhibitors. Bioorg Med Chem. 2008 Mar 1;16(5):2448-62. DMTUFI1 RU https://pubmed.ncbi.nlm.nih.gov/18083034 DMIQP69 DI DMIQP69 DMIQP69 DN XR-9504 DMIQP69 MI TT3OT40 DMIQP69 MN Multidrug resistance protein 1 (ABCB1) DMIQP69 MT DTT DMIQP69 MA Inhibitor DMIQP69 RN Functional assay and structure-activity relationships of new third-generation P-glycoprotein inhibitors. Bioorg Med Chem. 2008 Mar 1;16(5):2448-62. DMIQP69 RU https://pubmed.ncbi.nlm.nih.gov/18083034 DMIQP69 DI DMIQP69 DMIQP69 DN XR-9504 DMIQP69 MI TTOI92F DMIQP69 MN Multidrug resistance-associated protein 1 (ABCC1) DMIQP69 MT DTT DMIQP69 MA Inhibitor DMIQP69 RN Functional assay and structure-activity relationships of new third-generation P-glycoprotein inhibitors. Bioorg Med Chem. 2008 Mar 1;16(5):2448-62. DMIQP69 RU https://pubmed.ncbi.nlm.nih.gov/18083034 DM1OZPN DI DM1OZPN DM1OZPN DN XR-9544 DM1OZPN MI TT3OT40 DM1OZPN MN Multidrug resistance protein 1 (ABCB1) DM1OZPN MT DTT DM1OZPN MA Inhibitor DM1OZPN RN Functional assay and structure-activity relationships of new third-generation P-glycoprotein inhibitors. Bioorg Med Chem. 2008 Mar 1;16(5):2448-62. DM1OZPN RU https://pubmed.ncbi.nlm.nih.gov/18083034 DM1OZPN DI DM1OZPN DM1OZPN DN XR-9544 DM1OZPN MI TTOI92F DM1OZPN MN Multidrug resistance-associated protein 1 (ABCC1) DM1OZPN MT DTT DM1OZPN MA Inhibitor DM1OZPN RN Functional assay and structure-activity relationships of new third-generation P-glycoprotein inhibitors. Bioorg Med Chem. 2008 Mar 1;16(5):2448-62. DM1OZPN RU https://pubmed.ncbi.nlm.nih.gov/18083034 DMIZV6T DI DMIZV6T DMIZV6T DN XR-9577 DMIZV6T MI TT3OT40 DMIZV6T MN Multidrug resistance protein 1 (ABCB1) DMIZV6T MT DTT DMIZV6T MA Inhibitor DMIZV6T RN Functional assay and structure-activity relationships of new third-generation P-glycoprotein inhibitors. Bioorg Med Chem. 2008 Mar 1;16(5):2448-62. DMIZV6T RU https://pubmed.ncbi.nlm.nih.gov/18083034 DMIZV6T DI DMIZV6T DMIZV6T DN XR-9577 DMIZV6T MI TTOI92F DMIZV6T MN Multidrug resistance-associated protein 1 (ABCC1) DMIZV6T MT DTT DMIZV6T MA Inhibitor DMIZV6T RN Functional assay and structure-activity relationships of new third-generation P-glycoprotein inhibitors. Bioorg Med Chem. 2008 Mar 1;16(5):2448-62. DMIZV6T RU https://pubmed.ncbi.nlm.nih.gov/18083034 DM7BTNF DI DM7BTNF DM7BTNF DN XT-101 DM7BTNF MI TTJTRMK DM7BTNF MN Interleukin 10 receptor (IL10RB) DM7BTNF MT DTT DM7BTNF MA Modulator DM7BTNF RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1900). DM7BTNF RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1900 DML1K07 DI DML1K07 DML1K07 DN XV454 DML1K07 MI TT38RM1 DML1K07 MN Glycoprotein IIb/IIIa receptor (GPIIb/IIIa) DML1K07 MT DTT DML1K07 MA Antagonist DML1K07 RN Inhibition of tumor cell-induced platelet aggregation and lung metastasis by the oral GpIIb/IIIa antagonist XV454. Thromb Haemost. 2003 Sep;90(3):549-54. DML1K07 RU https://pubmed.ncbi.nlm.nih.gov/12958625 DMSXJUW DI DMSXJUW DMSXJUW DN xylazine DMSXJUW MI TTWM4TY DMSXJUW MN Adrenergic receptor alpha-2B (ADRA2B) DMSXJUW MT DTT DMSXJUW MA Agonist DMSXJUW RN Ligand efficacy and potency at recombinant alpha2 adrenergic receptors: agonist-mediated [35S]GTPgammaS binding. Biochem Pharmacol. 1998 Apr 1;55(7):1035-43. DMSXJUW RU https://pubmed.ncbi.nlm.nih.gov/9605427 DMSXJUW DI DMSXJUW DMSXJUW DN xylazine DMSXJUW MI TT2NUT5 DMSXJUW MN Adrenergic receptor alpha-2C (ADRA2C) DMSXJUW MT DTT DMSXJUW MA Agonist DMSXJUW RN Ligand efficacy and potency at recombinant alpha2 adrenergic receptors: agonist-mediated [35S]GTPgammaS binding. Biochem Pharmacol. 1998 Apr 1;55(7):1035-43. DMSXJUW RU https://pubmed.ncbi.nlm.nih.gov/9605427 DMZKPSQ DI DMZKPSQ DMZKPSQ DN Y-26763 DMZKPSQ MI TT1VOHK DMZKPSQ MN Potassium channel unspecific (KC) DMZKPSQ MT DTT DMZKPSQ MA Modulator DMZKPSQ RN Y-26763: ATP-sensitive K+ channel activation and the inhibition of insulin release from human pancreatic beta-cells. Eur J Pharmacol. 2004 Feb 20;486(2):133-9. DMZKPSQ RU https://www.ncbi.nlm.nih.gov/pubmed/14975702 DMC95YB DI DMC95YB DMC95YB DN Y-39041 DMC95YB MI TTF8CQI DMC95YB MN Tumor necrosis factor (TNF) DMC95YB MT DTT DMC95YB MA Inhibitor DMC95YB RN A novel anti-rheumatic drug suppresses tumor necrosis factor-alpha and augments interleukin-10 in adjuvant arthritic rats. Eur J Pharmacol. 2000 Dec 15;409(3):331-5. DMC95YB RU https://pubmed.ncbi.nlm.nih.gov/11108829 DM412IV DI DM412IV DM412IV DN Y-40613 DM412IV MI TT8VUE0 DM412IV MN Chymase (CYM) DM412IV MT DTT DM412IV MA Inhibitor DM412IV RN Therapeutic potential of a specific chymase inhibitor in atopic dermatitis. Jpn J Pharmacol. 2002 Nov;90(3):214-7. DM412IV RU https://pubmed.ncbi.nlm.nih.gov/12499574 DMUW4KG DI DMUW4KG DMUW4KG DN YAWF-NH2 DMUW4KG MI TTKWM86 DMUW4KG MN Opioid receptor mu (MOP) DMUW4KG MT DTT DMUW4KG MA Inhibitor DMUW4KG RN Internalisation of the mu-opioid receptor by endomorphin-1 and leu-enkephalin is dependant on aromatic amino acid residues. Bioorg Med Chem. 2008 Apr 15;16(8):4341-6. DMUW4KG RU https://pubmed.ncbi.nlm.nih.gov/18329886 DMAC65P DI DMAC65P DMAC65P DN Y-c[D-Pen-(2')Nal-GSFC]KR-NH2 DMAC65P MI TT6PKBN DMAC65P MN Proto-oncogene c-Src (SRC) DMAC65P MT DTT DMAC65P MA Inhibitor DMAC65P RN Discovery of a novel series of potent and selective substrate-based inhibitors of p60c-src protein tyrosine kinase: conformational and topographica... J Med Chem. 1998 Jun 18;41(13):2252-60. DMAC65P RU https://pubmed.ncbi.nlm.nih.gov/9632358 DMEL4UN DI DMEL4UN DMEL4UN DN Y-c[D-Pen-(2R,3R)-2-Me-(2')Nal-GSFC]KR-NH2 DMEL4UN MI TT6PKBN DMEL4UN MN Proto-oncogene c-Src (SRC) DMEL4UN MT DTT DMEL4UN MA Inhibitor DMEL4UN RN Discovery of a novel series of potent and selective substrate-based inhibitors of p60c-src protein tyrosine kinase: conformational and topographica... J Med Chem. 1998 Jun 18;41(13):2252-60. DMEL4UN RU https://pubmed.ncbi.nlm.nih.gov/9632358 DM7P0H6 DI DM7P0H6 DM7P0H6 DN Y-c[D-Pen-(2R,3S)-2-Me-(2')Nal-GSFC]KR-NH2 DM7P0H6 MI TT6PKBN DM7P0H6 MN Proto-oncogene c-Src (SRC) DM7P0H6 MT DTT DM7P0H6 MA Inhibitor DM7P0H6 RN Discovery of a novel series of potent and selective substrate-based inhibitors of p60c-src protein tyrosine kinase: conformational and topographica... J Med Chem. 1998 Jun 18;41(13):2252-60. DM7P0H6 RU https://pubmed.ncbi.nlm.nih.gov/9632358 DMBNM85 DI DMBNM85 DMBNM85 DN Y-c[D-Pen-(2S,3R)-2-Me-(2')Nal-GSFC]KR-NH2 DMBNM85 MI TT6PKBN DMBNM85 MN Proto-oncogene c-Src (SRC) DMBNM85 MT DTT DMBNM85 MA Inhibitor DMBNM85 RN Discovery of a novel series of potent and selective substrate-based inhibitors of p60c-src protein tyrosine kinase: conformational and topographica... J Med Chem. 1998 Jun 18;41(13):2252-60. DMBNM85 RU https://pubmed.ncbi.nlm.nih.gov/9632358 DME1BGO DI DME1BGO DME1BGO DN Y-c[D-Pen-(2S,3S)-2-Me-(2')Nal-GSFC]KR-NH2 DME1BGO MI TT6PKBN DME1BGO MN Proto-oncogene c-Src (SRC) DME1BGO MT DTT DME1BGO MA Inhibitor DME1BGO RN Discovery of a novel series of potent and selective substrate-based inhibitors of p60c-src protein tyrosine kinase: conformational and topographica... J Med Chem. 1998 Jun 18;41(13):2252-60. DME1BGO RU https://pubmed.ncbi.nlm.nih.gov/9632358 DMF7S54 DI DMF7S54 DMF7S54 DN Y-c[D-Pen-(3,5-diI)Tyr-GSFC]KR-NH2 DMF7S54 MI TT860QF DMF7S54 MN LCK tyrosine protein kinase (LCK) DMF7S54 MT DTT DMF7S54 MA Inhibitor DMF7S54 RN Discovery of a novel series of potent and selective substrate-based inhibitors of p60c-src protein tyrosine kinase: conformational and topographica... J Med Chem. 1998 Jun 18;41(13):2252-60. DMF7S54 RU https://pubmed.ncbi.nlm.nih.gov/9632358 DMF7S54 DI DMF7S54 DMF7S54 DN Y-c[D-Pen-(3,5-diI)Tyr-GSFC]KR-NH2 DMF7S54 MI TT6PKBN DMF7S54 MN Proto-oncogene c-Src (SRC) DMF7S54 MT DTT DMF7S54 MA Inhibitor DMF7S54 RN Discovery of a novel series of potent and selective substrate-based inhibitors of p60c-src protein tyrosine kinase: conformational and topographica... J Med Chem. 1998 Jun 18;41(13):2252-60. DMF7S54 RU https://pubmed.ncbi.nlm.nih.gov/9632358 DMW1PSO DI DMW1PSO DMW1PSO DN Y-c[D-Pen-(3-I)Tyr-GSFC]KR-NH2 DMW1PSO MI TT860QF DMW1PSO MN LCK tyrosine protein kinase (LCK) DMW1PSO MT DTT DMW1PSO MA Inhibitor DMW1PSO RN Discovery of a novel series of potent and selective substrate-based inhibitors of p60c-src protein tyrosine kinase: conformational and topographica... J Med Chem. 1998 Jun 18;41(13):2252-60. DMW1PSO RU https://pubmed.ncbi.nlm.nih.gov/9632358 DMW1PSO DI DMW1PSO DMW1PSO DN Y-c[D-Pen-(3-I)Tyr-GSFC]KR-NH2 DMW1PSO MI TT6PKBN DMW1PSO MN Proto-oncogene c-Src (SRC) DMW1PSO MT DTT DMW1PSO MA Inhibitor DMW1PSO RN Discovery of a novel series of potent and selective substrate-based inhibitors of p60c-src protein tyrosine kinase: conformational and topographica... J Med Chem. 1998 Jun 18;41(13):2252-60. DMW1PSO RU https://pubmed.ncbi.nlm.nih.gov/9632358 DM2ILAH DI DM2ILAH DM2ILAH DN Y-c[D-Pen-D-(2')Nal-GSFC]KR-NH2 DM2ILAH MI TT6PKBN DM2ILAH MN Proto-oncogene c-Src (SRC) DM2ILAH MT DTT DM2ILAH MA Inhibitor DM2ILAH RN Discovery of a novel series of potent and selective substrate-based inhibitors of p60c-src protein tyrosine kinase: conformational and topographica... J Med Chem. 1998 Jun 18;41(13):2252-60. DM2ILAH RU https://pubmed.ncbi.nlm.nih.gov/9632358 DM5LYKW DI DM5LYKW DM5LYKW DN YGGWL-NH2 DM5LYKW MI TTKWM86 DM5LYKW MN Opioid receptor mu (MOP) DM5LYKW MT DTT DM5LYKW MA Inhibitor DM5LYKW RN Internalisation of the mu-opioid receptor by endomorphin-1 and leu-enkephalin is dependant on aromatic amino acid residues. Bioorg Med Chem. 2008 Apr 15;16(8):4341-6. DM5LYKW RU https://pubmed.ncbi.nlm.nih.gov/18329886 DMV89B4 DI DMV89B4 DMV89B4 DN YGRKKRRQRRR-KLSSIESDV DMV89B4 MI TT9PB26 DMV89B4 MN Presynaptic density protein 95 (DLG4) DMV89B4 MT DTT DMV89B4 MA Inhibitor DMV89B4 RN Modified peptides as potent inhibitors of the postsynaptic density-95/N-methyl-D-aspartate receptor interaction. J Med Chem. 2008 Oct 23;51(20):6450-9. DMV89B4 RU https://pubmed.ncbi.nlm.nih.gov/18811137 DMQ2EYJ DI DMQ2EYJ DMQ2EYJ DN YGWFL-NH2 DMQ2EYJ MI TTKWM86 DMQ2EYJ MN Opioid receptor mu (MOP) DMQ2EYJ MT DTT DMQ2EYJ MA Inhibitor DMQ2EYJ RN Internalisation of the mu-opioid receptor by endomorphin-1 and leu-enkephalin is dependant on aromatic amino acid residues. Bioorg Med Chem. 2008 Apr 15;16(8):4341-6. DMQ2EYJ RU https://pubmed.ncbi.nlm.nih.gov/18329886 DM6FEMV DI DM6FEMV DM6FEMV DN YH-1238 DM6FEMV MI TTLOKXP DM6FEMV MN Gastric H(+)/K(+) ATPase (Proton pump) DM6FEMV MT DTT DM6FEMV MA Modulator DM6FEMV RN Compositions for improving gastrointestinal nutrient and drug absorption DM6FEMV RU https://www.google.com/patents/US20080193531 DML1JY4 DI DML1JY4 DML1JY4 DN YIL781 DML1JY4 MI TTWDC17 DML1JY4 MN Growth hormone secretagogue receptor 1 (GHSR) DML1JY4 MT DTT DML1JY4 MA Antagonist DML1JY4 RN Small-molecule ghrelin receptor antagonists improve glucose tolerance, suppress appetite, and promote weight loss. Endocrinology. 2007 Nov;148(11):5175-85. DML1JY4 RU https://pubmed.ncbi.nlm.nih.gov/17656463 DMU0NHX DI DMU0NHX DMU0NHX DN YK-3237 DMU0NHX MI TTUF2HO DMU0NHX MN NAD-dependent deacetylase sirtuin-1 (SIRT1) DMU0NHX MT DTT DMU0NHX MA Inhibitor DMU0NHX RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2707). DMU0NHX RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2707 DMPYM3J DI DMPYM3J DMPYM3J DN YM 218 DMPYM3J MI TT4TFGN DMPYM3J MN Vasopressin V1a receptor (V1AR) DMPYM3J MT DTT DMPYM3J MA Antagonist DMPYM3J RN Effects of YM218, a nonpeptide vasopressin V1A receptor-selective antagonist, on human vasopressin and oxytocin receptors. Pharmacol Res. 2005 Mar;51(3):275-81. DMPYM3J RU https://pubmed.ncbi.nlm.nih.gov/15661579 DMPYM3J DI DMPYM3J DMPYM3J DN YM 218 DMPYM3J MI TTL9MHW DMPYM3J MN Vasopressin V1b receptor (V1BR) DMPYM3J MT DTT DMPYM3J MA Antagonist DMPYM3J RN Effects of YM218, a nonpeptide vasopressin V1A receptor-selective antagonist, on human vasopressin and oxytocin receptors. Pharmacol Res. 2005 Mar;51(3):275-81. DMPYM3J RU https://pubmed.ncbi.nlm.nih.gov/15661579 DMPYM3J DI DMPYM3J DMPYM3J DN YM 218 DMPYM3J MI TTK8R02 DMPYM3J MN Vasopressin V2 receptor (V2R) DMPYM3J MT DTT DMPYM3J MA Antagonist DMPYM3J RN Effects of YM218, a nonpeptide vasopressin V1A receptor-selective antagonist, on human vasopressin and oxytocin receptors. Pharmacol Res. 2005 Mar;51(3):275-81. DMPYM3J RU https://pubmed.ncbi.nlm.nih.gov/15661579 DM5BFL4 DI DM5BFL4 DM5BFL4 DN YM 471 DM5BFL4 MI TT4TFGN DM5BFL4 MN Vasopressin V1a receptor (V1AR) DM5BFL4 MT DTT DM5BFL4 MA Antagonist DM5BFL4 RN Effects of YM471, a nonpeptide AVP V(1A) and V(2) receptor antagonist, on human AVP receptor subtypes expressed in CHO cells and oxytocin receptors in human uterine smooth muscle cells. Br J Pharmacol. 2001 Jul;133(5):746-54. DM5BFL4 RU https://pubmed.ncbi.nlm.nih.gov/11429400 DM5BFL4 DI DM5BFL4 DM5BFL4 DN YM 471 DM5BFL4 MI TTL9MHW DM5BFL4 MN Vasopressin V1b receptor (V1BR) DM5BFL4 MT DTT DM5BFL4 MA Antagonist DM5BFL4 RN Effects of YM471, a nonpeptide AVP V(1A) and V(2) receptor antagonist, on human AVP receptor subtypes expressed in CHO cells and oxytocin receptors in human uterine smooth muscle cells. Br J Pharmacol. 2001 Jul;133(5):746-54. DM5BFL4 RU https://pubmed.ncbi.nlm.nih.gov/11429400 DM5BFL4 DI DM5BFL4 DM5BFL4 DN YM 471 DM5BFL4 MI TTK8R02 DM5BFL4 MN Vasopressin V2 receptor (V2R) DM5BFL4 MT DTT DM5BFL4 MA Antagonist DM5BFL4 RN Effects of YM471, a nonpeptide AVP V(1A) and V(2) receptor antagonist, on human AVP receptor subtypes expressed in CHO cells and oxytocin receptors in human uterine smooth muscle cells. Br J Pharmacol. 2001 Jul;133(5):746-54. DM5BFL4 RU https://pubmed.ncbi.nlm.nih.gov/11429400 DMMW3L1 DI DMMW3L1 DMMW3L1 DN YM-175735 DMMW3L1 MI TTKPW01 DMMW3L1 MN Androgen receptor messenger RNA (AR mRNA) DMMW3L1 MT DTT DMMW3L1 MA Inhibitor DMMW3L1 RN (+)-(2R,5S)-4-[4-cyano-3-(trifluoromethyl)phenyl]-2,5-dimethyl-N-[6-(trifluoromethyl)pyridin-3- yl]piperazine-1-carboxamide (YM580) as an orally po... J Med Chem. 2006 Jan 26;49(2):716-26. DMMW3L1 RU https://pubmed.ncbi.nlm.nih.gov/16420057 DM3IOLR DI DM3IOLR DM3IOLR DN YM-202074 DM3IOLR MI TTVBPDM DM3IOLR MN Metabotropic glutamate receptor 1 (mGluR1) DM3IOLR MT DTT DM3IOLR MA Modulator (allosteric modulator) DM3IOLR RN Neuroprotective effects of the selective type 1 metabotropic glutamate receptor antagonist YM-202074 in rat stroke models. Brain Res. 2008 Jan 29;1191:168-79. DM3IOLR RU https://pubmed.ncbi.nlm.nih.gov/18164695 DMUYDXT DI DMUYDXT DMUYDXT DN YM298198 DMUYDXT MI TTVBPDM DMUYDXT MN Metabotropic glutamate receptor 1 (mGluR1) DMUYDXT MT DTT DMUYDXT MA Modulator (allosteric modulator) DMUYDXT RN Radioligand binding properties and pharmacological characterization of 6-amino-N-cyclohexyl-N,3-dimethylthiazolo[3,2-a]benzimidazole-2-carboxamide ... J Pharmacol Exp Ther. 2005 Oct;315(1):163-9. DMUYDXT RU https://pubmed.ncbi.nlm.nih.gov/15976016 DM38F9T DI DM38F9T DM38F9T DN YM-348 DM38F9T MI TTJQOD7 DM38F9T MN 5-HT 2A receptor (HTR2A) DM38F9T MT DTT DM38F9T MA Inhibitor DM38F9T RN Synthesis and structure-activity relationships of a series of benzazepine derivatives as 5-HT2C receptor agonists. Bioorg Med Chem. 2008 Mar 15;16(6):3309-20. DM38F9T RU https://pubmed.ncbi.nlm.nih.gov/18083579 DM38F9T DI DM38F9T DM38F9T DN YM-348 DM38F9T MI TT0K1SC DM38F9T MN 5-HT 2B receptor (HTR2B) DM38F9T MT DTT DM38F9T MA Inhibitor DM38F9T RN Synthesis and structure-activity relationships of a series of benzazepine derivatives as 5-HT2C receptor agonists. Bioorg Med Chem. 2008 Mar 15;16(6):3309-20. DM38F9T RU https://pubmed.ncbi.nlm.nih.gov/18083579 DM38F9T DI DM38F9T DM38F9T DN YM-348 DM38F9T MI TTWJBZ5 DM38F9T MN 5-HT 2C receptor (HTR2C) DM38F9T MT DTT DM38F9T MA Inhibitor DM38F9T RN Synthesis and structure-activity relationships of a series of benzazepine derivatives as 5-HT2C receptor agonists. Bioorg Med Chem. 2008 Mar 15;16(6):3309-20. DM38F9T RU https://pubmed.ncbi.nlm.nih.gov/18083579 DMXRZ6N DI DMXRZ6N DMXRZ6N DN YM-35278 DMXRZ6N MI TTK8R02 DMXRZ6N MN Vasopressin V2 receptor (V2R) DMXRZ6N MT DTT DMXRZ6N MA Inhibitor DMXRZ6N RN Preparation of (4,4-difluoro-1,2,3,4-tetrahydro-5H-1-benzazepin-5-ylidene)acetamide derivatives as novel arginine vasopressin V(2) receptor agonists. Bioorg Med Chem. 2008 Nov 1;16(21):9524-35. DMXRZ6N RU https://pubmed.ncbi.nlm.nih.gov/18835174 DMDOR2L DI DMDOR2L DMDOR2L DN YM44778 DMDOR2L MI TTYO0A3 DMDOR2L MN Substance-K receptor (TACR2) DMDOR2L MT DTT DMDOR2L MA Antagonist DMDOR2L RN Effect of YM-44781, YM-44778 and YM-49598, novel tachykinin antagonists, in a drug-induced bladder contraction model. Pharmacology. 2002 May;65(2):96-102. DMDOR2L RU https://pubmed.ncbi.nlm.nih.gov/11937780 DM73AEL DI DM73AEL DM73AEL DN YM44781 DM73AEL MI TTYO0A3 DM73AEL MN Substance-K receptor (TACR2) DM73AEL MT DTT DM73AEL MA Antagonist DM73AEL RN Effect of YM-44781, YM-44778 and YM-49598, novel tachykinin antagonists, in a drug-induced bladder contraction model. Pharmacology. 2002 May;65(2):96-102. DM73AEL RU https://pubmed.ncbi.nlm.nih.gov/11937780 DMTYSUN DI DMTYSUN DMTYSUN DN YM49598 DMTYSUN MI TTYO0A3 DMTYSUN MN Substance-K receptor (TACR2) DMTYSUN MT DTT DMTYSUN MA Antagonist DMTYSUN RN Effect of YM-44781, YM-44778 and YM-49598, novel tachykinin antagonists, in a drug-induced bladder contraction model. Pharmacology. 2002 May;65(2):96-102. DMTYSUN RU https://pubmed.ncbi.nlm.nih.gov/11937780 DMMCXWQ DI DMMCXWQ DMMCXWQ DN YM-75440 DMMCXWQ MI TTFQEO5 DMMCXWQ MN Squalene synthetase (FDFT1) DMMCXWQ MT DTT DMMCXWQ MA Inhibitor DMMCXWQ RN Synthesis and biological evaluation of novel propylamine derivatives as orally active squalene synthase inhibitors. Bioorg Med Chem. 2004 Nov 15;12(22):5899-908. DMMCXWQ RU https://pubmed.ncbi.nlm.nih.gov/15498666 DML5DU0 DI DML5DU0 DML5DU0 DN YM90709 DML5DU0 MI TTXH9AD DML5DU0 MN Interleukin 5 receptor alpha (IL5RA) DML5DU0 MT DTT DML5DU0 MA Antagonist DML5DU0 RN Characterization of YM-90709 as a novel antagonist which inhibits the binding of interleukin-5 to interleukin-5 receptor. Int Immunopharmacol. 2002 Nov;2(12):1693-702. DML5DU0 RU https://pubmed.ncbi.nlm.nih.gov/12469943 DMPU5TC DI DMPU5TC DMPU5TC DN YM-96765 DMPU5TC MI TTCIHJA DMPU5TC MN Coagulation factor Xa (F10) DMPU5TC MT DTT DMPU5TC MA Inhibitor DMPU5TC RN Synthesis and biological activity of novel 1,4-diazepane derivatives as factor Xa inhibitor with potent anticoagulant and antithrombotic activity. Bioorg Med Chem. 2004 May 1;12(9):2179-91. DMPU5TC RU https://pubmed.ncbi.nlm.nih.gov/15080918 DMC3DK5 DI DMC3DK5 DMC3DK5 DN YPAA-NH2 DMC3DK5 MI TTKWM86 DMC3DK5 MN Opioid receptor mu (MOP) DMC3DK5 MT DTT DMC3DK5 MA Inhibitor DMC3DK5 RN Internalisation of the mu-opioid receptor by endomorphin-1 and leu-enkephalin is dependant on aromatic amino acid residues. Bioorg Med Chem. 2008 Apr 15;16(8):4341-6. DMC3DK5 RU https://pubmed.ncbi.nlm.nih.gov/18329886 DMOTHAC DI DMOTHAC DMOTHAC DN YPWA-NH2 DMOTHAC MI TTKWM86 DMOTHAC MN Opioid receptor mu (MOP) DMOTHAC MT DTT DMOTHAC MA Inhibitor DMOTHAC RN Internalisation of the mu-opioid receptor by endomorphin-1 and leu-enkephalin is dependant on aromatic amino acid residues. Bioorg Med Chem. 2008 Apr 15;16(8):4341-6. DMOTHAC RU https://pubmed.ncbi.nlm.nih.gov/18329886 DMXOJIB DI DMXOJIB DMXOJIB DN YRFB DMXOJIB MI TTKWM86 DMXOJIB MN Opioid receptor mu (MOP) DMXOJIB MT DTT DMXOJIB MA Inhibitor DMXOJIB RN Synthesis and receptor binding properties of chimeric peptides containing a mu-opioid receptor ligand and nociceptin/orphanin FQ receptor ligand Ac... Bioorg Med Chem Lett. 2006 Sep 15;16(18):4839-41. DMXOJIB RU https://pubmed.ncbi.nlm.nih.gov/16814543 DMTURZ6 DI DMTURZ6 DMTURZ6 DN YS110 mAb clone DMTURZ6 MI TTF928K DMTURZ6 MN HUMAN dipeptidyl peptidase 4 (DPP-4) DMTURZ6 MT DTT DMTURZ6 MA Blocker DMTURZ6 RN Coronaviruses - drug discovery and therapeutic options. Nat Rev Drug Discov. 2016 May;15(5):327-47. DMTURZ6 RU https://pubmed.ncbi.nlm.nih.gov/26868298 DM24LNB DI DM24LNB DM24LNB DN YVAD DM24LNB MI TTCQIBE DM24LNB MN Caspase-1 (CASP1) DM24LNB MT DTT DM24LNB MA Inhibitor DM24LNB RN Mice deficient in interleukin-1beta converting enzyme resist anorexia induced by central lipopolysaccharide. Am J Physiol. 1999 Nov;277(5 Pt 2):R1435-43. DM24LNB RU https://pubmed.ncbi.nlm.nih.gov/10564217 DMFT51X DI DMFT51X DMFT51X DN Z 944 DMFT51X MI TTZPWGN DMFT51X MN Voltage-gated calcium channel alpha Cav3.2 (CACNA1H) DMFT51X MT DTT DMFT51X MA Modulator DMFT51X RN Z944, a Novel Selective T-Type Calcium Channel Antagonist Delays the Progression of Seizures in the Amygdala Kindling Model.PLoS One.2015 Aug 14;10(8):e0130012. DMFT51X RU https://www.ncbi.nlm.nih.gov/pubmed/26274319 DMMP0DT DI DMMP0DT DMMP0DT DN Z-Ala-Leu-His-Agly-Ile-Val-OMe DMMP0DT MI TTF2LRI DMMP0DT MN Cathepsin B (CTSB) DMMP0DT MT DTT DMMP0DT MA Inhibitor DMMP0DT RN Azapeptides structurally based upon inhibitory sites of cystatins as potent and selective inhibitors of cysteine proteases. J Med Chem. 2002 Sep 12;45(19):4202-11. DMMP0DT RU https://pubmed.ncbi.nlm.nih.gov/12213061 DMMP0DT DI DMMP0DT DMMP0DT DN Z-Ala-Leu-His-Agly-Ile-Val-OMe DMMP0DT MI TTDZN01 DMMP0DT MN Cathepsin K (CTSK) DMMP0DT MT DTT DMMP0DT MA Inhibitor DMMP0DT RN Azapeptides structurally based upon inhibitory sites of cystatins as potent and selective inhibitors of cysteine proteases. J Med Chem. 2002 Sep 12;45(19):4202-11. DMMP0DT RU https://pubmed.ncbi.nlm.nih.gov/12213061 DM7IGRT DI DM7IGRT DM7IGRT DN Z-Ala-Leu-lle-Agly-Ile-Val-NHBzl DM7IGRT MI TTF2LRI DM7IGRT MN Cathepsin B (CTSB) DM7IGRT MT DTT DM7IGRT MA Inhibitor DM7IGRT RN Azapeptides structurally based upon inhibitory sites of cystatins as potent and selective inhibitors of cysteine proteases. J Med Chem. 2002 Sep 12;45(19):4202-11. DM7IGRT RU https://pubmed.ncbi.nlm.nih.gov/12213061 DM7IGRT DI DM7IGRT DM7IGRT DN Z-Ala-Leu-lle-Agly-Ile-Val-NHBzl DM7IGRT MI TTDZN01 DM7IGRT MN Cathepsin K (CTSK) DM7IGRT MT DTT DM7IGRT MA Inhibitor DM7IGRT RN Azapeptides structurally based upon inhibitory sites of cystatins as potent and selective inhibitors of cysteine proteases. J Med Chem. 2002 Sep 12;45(19):4202-11. DM7IGRT RU https://pubmed.ncbi.nlm.nih.gov/12213061 DMVEUOL DI DMVEUOL DMVEUOL DN Z-Ala-Leu-lle-Agly-Ile-Val-OMe DMVEUOL MI TTF2LRI DMVEUOL MN Cathepsin B (CTSB) DMVEUOL MT DTT DMVEUOL MA Inhibitor DMVEUOL RN Azapeptides structurally based upon inhibitory sites of cystatins as potent and selective inhibitors of cysteine proteases. J Med Chem. 2002 Sep 12;45(19):4202-11. DMVEUOL RU https://pubmed.ncbi.nlm.nih.gov/12213061 DMVEUOL DI DMVEUOL DMVEUOL DN Z-Ala-Leu-lle-Agly-Ile-Val-OMe DMVEUOL MI TTDZN01 DMVEUOL MN Cathepsin K (CTSK) DMVEUOL MT DTT DMVEUOL MA Inhibitor DMVEUOL RN Azapeptides structurally based upon inhibitory sites of cystatins as potent and selective inhibitors of cysteine proteases. J Med Chem. 2002 Sep 12;45(19):4202-11. DMVEUOL RU https://pubmed.ncbi.nlm.nih.gov/12213061 DM3209T DI DM3209T DM3209T DN Z-Ala-Leu-Nal-Agly-Ile-Val-OMe DM3209T MI TTF2LRI DM3209T MN Cathepsin B (CTSB) DM3209T MT DTT DM3209T MA Inhibitor DM3209T RN Azapeptides structurally based upon inhibitory sites of cystatins as potent and selective inhibitors of cysteine proteases. J Med Chem. 2002 Sep 12;45(19):4202-11. DM3209T RU https://pubmed.ncbi.nlm.nih.gov/12213061 DM3209T DI DM3209T DM3209T DN Z-Ala-Leu-Nal-Agly-Ile-Val-OMe DM3209T MI TTDZN01 DM3209T MN Cathepsin K (CTSK) DM3209T MT DTT DM3209T MA Inhibitor DM3209T RN Azapeptides structurally based upon inhibitory sites of cystatins as potent and selective inhibitors of cysteine proteases. J Med Chem. 2002 Sep 12;45(19):4202-11. DM3209T RU https://pubmed.ncbi.nlm.nih.gov/12213061 DML16BT DI DML16BT DML16BT DN Z-Ala-Leu-Phe-Agly-Ile-Val-OMe DML16BT MI TTF2LRI DML16BT MN Cathepsin B (CTSB) DML16BT MT DTT DML16BT MA Inhibitor DML16BT RN Azapeptides structurally based upon inhibitory sites of cystatins as potent and selective inhibitors of cysteine proteases. J Med Chem. 2002 Sep 12;45(19):4202-11. DML16BT RU https://pubmed.ncbi.nlm.nih.gov/12213061 DML16BT DI DML16BT DML16BT DN Z-Ala-Leu-Phe-Agly-Ile-Val-OMe DML16BT MI TTDZN01 DML16BT MN Cathepsin K (CTSK) DML16BT MT DTT DML16BT MA Inhibitor DML16BT RN Azapeptides structurally based upon inhibitory sites of cystatins as potent and selective inhibitors of cysteine proteases. J Med Chem. 2002 Sep 12;45(19):4202-11. DML16BT RU https://pubmed.ncbi.nlm.nih.gov/12213061 DMIB5O3 DI DMIB5O3 DMIB5O3 DN Z-Ala-Leu-Tyr(Me)-Agly-Ile-Val-OMe DMIB5O3 MI TTF2LRI DMIB5O3 MN Cathepsin B (CTSB) DMIB5O3 MT DTT DMIB5O3 MA Inhibitor DMIB5O3 RN Azapeptides structurally based upon inhibitory sites of cystatins as potent and selective inhibitors of cysteine proteases. J Med Chem. 2002 Sep 12;45(19):4202-11. DMIB5O3 RU https://pubmed.ncbi.nlm.nih.gov/12213061 DMIB5O3 DI DMIB5O3 DMIB5O3 DN Z-Ala-Leu-Tyr(Me)-Agly-Ile-Val-OMe DMIB5O3 MI TTDZN01 DMIB5O3 MN Cathepsin K (CTSK) DMIB5O3 MT DTT DMIB5O3 MA Inhibitor DMIB5O3 RN Azapeptides structurally based upon inhibitory sites of cystatins as potent and selective inhibitors of cysteine proteases. J Med Chem. 2002 Sep 12;45(19):4202-11. DMIB5O3 RU https://pubmed.ncbi.nlm.nih.gov/12213061 DMM4ZKU DI DMM4ZKU DMM4ZKU DN ZAPOTIN DMM4ZKU MI TTUMGNO DMM4ZKU MN Ornithine decarboxylase (ODC1) DMM4ZKU MT DTT DMM4ZKU MA Inhibitor DMM4ZKU RN Synthesis and cancer chemopreventive activity of zapotin, a natural product from Casimiroa edulis. J Med Chem. 2007 Jan 25;50(2):350-5. DMM4ZKU RU https://pubmed.ncbi.nlm.nih.gov/17228877 DMYRLA0 DI DMYRLA0 DMYRLA0 DN ZARAGOZIC ACID B DMYRLA0 MI TTFQEO5 DMYRLA0 MN Squalene synthetase (FDFT1) DMYRLA0 MT DTT DMYRLA0 MA Inhibitor DMYRLA0 RN Zaragozic acids D and D2: potent inhibitors of squalene synthase and of Ras farnesyl-protein transferase. J Nat Prod. 1993 Nov;56(11):1923-9. DMYRLA0 RU https://pubmed.ncbi.nlm.nih.gov/8289063 DMUQWP1 DI DMUQWP1 DMUQWP1 DN Zaragozic Acid C DMUQWP1 MI TTFQEO5 DMUQWP1 MN Squalene synthetase (FDFT1) DMUQWP1 MT DTT DMUQWP1 MA Inhibitor DMUQWP1 RN Zaragozic acids D and D2: potent inhibitors of squalene synthase and of Ras farnesyl-protein transferase. J Nat Prod. 1993 Nov;56(11):1923-9. DMUQWP1 RU https://pubmed.ncbi.nlm.nih.gov/8289063 DMMTJE3 DI DMMTJE3 DMMTJE3 DN Zaragozic Acid D DMMTJE3 MI TTFQEO5 DMMTJE3 MN Squalene synthetase (FDFT1) DMMTJE3 MT DTT DMMTJE3 MA Inhibitor DMMTJE3 RN Zaragozic acids D and D2: potent inhibitors of squalene synthase and of Ras farnesyl-protein transferase. J Nat Prod. 1993 Nov;56(11):1923-9. DMMTJE3 RU https://pubmed.ncbi.nlm.nih.gov/8289063 DML4WQJ DI DML4WQJ DML4WQJ DN Zaragozic Acid D2 DML4WQJ MI TTFQEO5 DML4WQJ MN Squalene synthetase (FDFT1) DML4WQJ MT DTT DML4WQJ MA Inhibitor DML4WQJ RN Zaragozic acids D and D2: potent inhibitors of squalene synthase and of Ras farnesyl-protein transferase. J Nat Prod. 1993 Nov;56(11):1923-9. DML4WQJ RU https://pubmed.ncbi.nlm.nih.gov/8289063 DM69FKN DI DM69FKN DM69FKN DN Z-Arg-Leu-Val-Agly-Ala-Gly-NH2 DM69FKN MI TTF2LRI DM69FKN MN Cathepsin B (CTSB) DM69FKN MT DTT DM69FKN MA Inhibitor DM69FKN RN Azapeptides structurally based upon inhibitory sites of cystatins as potent and selective inhibitors of cysteine proteases. J Med Chem. 2002 Sep 12;45(19):4202-11. DM69FKN RU https://pubmed.ncbi.nlm.nih.gov/12213061 DM69FKN DI DM69FKN DM69FKN DN Z-Arg-Leu-Val-Agly-Ala-Gly-NH2 DM69FKN MI TTDZN01 DM69FKN MN Cathepsin K (CTSK) DM69FKN MT DTT DM69FKN MA Inhibitor DM69FKN RN Azapeptides structurally based upon inhibitory sites of cystatins as potent and selective inhibitors of cysteine proteases. J Med Chem. 2002 Sep 12;45(19):4202-11. DM69FKN RU https://pubmed.ncbi.nlm.nih.gov/12213061 DMT0UZ1 DI DMT0UZ1 DMT0UZ1 DN Z-Arg-Leu-Val-Agly-Ileu-Val-OMe DMT0UZ1 MI TTF2LRI DMT0UZ1 MN Cathepsin B (CTSB) DMT0UZ1 MT DTT DMT0UZ1 MA Inhibitor DMT0UZ1 RN Azapeptides structurally based upon inhibitory sites of cystatins as potent and selective inhibitors of cysteine proteases. J Med Chem. 2002 Sep 12;45(19):4202-11. DMT0UZ1 RU https://pubmed.ncbi.nlm.nih.gov/12213061 DMT0UZ1 DI DMT0UZ1 DMT0UZ1 DN Z-Arg-Leu-Val-Agly-Ileu-Val-OMe DMT0UZ1 MI TTDZN01 DMT0UZ1 MN Cathepsin K (CTSK) DMT0UZ1 MT DTT DMT0UZ1 MA Inhibitor DMT0UZ1 RN Azapeptides structurally based upon inhibitory sites of cystatins as potent and selective inhibitors of cysteine proteases. J Med Chem. 2002 Sep 12;45(19):4202-11. DMT0UZ1 RU https://pubmed.ncbi.nlm.nih.gov/12213061 DM9SXMB DI DM9SXMB DM9SXMB DN Z-Arg-Leu-Val-Agly-Ile-Val-OMe DM9SXMB MI TTF2LRI DM9SXMB MN Cathepsin B (CTSB) DM9SXMB MT DTT DM9SXMB MA Inhibitor DM9SXMB RN Azapeptides structurally based upon inhibitory sites of cystatins as potent and selective inhibitors of cysteine proteases. J Med Chem. 2002 Sep 12;45(19):4202-11. DM9SXMB RU https://pubmed.ncbi.nlm.nih.gov/12213061 DMZDGJO DI DMZDGJO DMZDGJO DN Z-Arg-Leu-Val-Agly-Ile-Val-Trp-NH2 DMZDGJO MI TTF2LRI DMZDGJO MN Cathepsin B (CTSB) DMZDGJO MT DTT DMZDGJO MA Inhibitor DMZDGJO RN Azapeptides structurally based upon inhibitory sites of cystatins as potent and selective inhibitors of cysteine proteases. J Med Chem. 2002 Sep 12;45(19):4202-11. DMZDGJO RU https://pubmed.ncbi.nlm.nih.gov/12213061 DMZDGJO DI DMZDGJO DMZDGJO DN Z-Arg-Leu-Val-Agly-Ile-Val-Trp-NH2 DMZDGJO MI TTDZN01 DMZDGJO MN Cathepsin K (CTSK) DMZDGJO MT DTT DMZDGJO MA Inhibitor DMZDGJO RN Azapeptides structurally based upon inhibitory sites of cystatins as potent and selective inhibitors of cysteine proteases. J Med Chem. 2002 Sep 12;45(19):4202-11. DMZDGJO RU https://pubmed.ncbi.nlm.nih.gov/12213061 DMM5O2V DI DMM5O2V DMM5O2V DN Z-Arg-Leu-Val-Agly-Trp-Val-Ala-NH2 DMM5O2V MI TTF2LRI DMM5O2V MN Cathepsin B (CTSB) DMM5O2V MT DTT DMM5O2V MA Inhibitor DMM5O2V RN Azapeptides structurally based upon inhibitory sites of cystatins as potent and selective inhibitors of cysteine proteases. J Med Chem. 2002 Sep 12;45(19):4202-11. DMM5O2V RU https://pubmed.ncbi.nlm.nih.gov/12213061 DMM5O2V DI DMM5O2V DMM5O2V DN Z-Arg-Leu-Val-Agly-Trp-Val-Ala-NH2 DMM5O2V MI TTDZN01 DMM5O2V MN Cathepsin K (CTSK) DMM5O2V MT DTT DMM5O2V MA Inhibitor DMM5O2V RN Azapeptides structurally based upon inhibitory sites of cystatins as potent and selective inhibitors of cysteine proteases. J Med Chem. 2002 Sep 12;45(19):4202-11. DMM5O2V RU https://pubmed.ncbi.nlm.nih.gov/12213061 DMTWNH7 DI DMTWNH7 DMTWNH7 DN Z-Arg-Leu-Val-Agly-Val-Ala-NH2 DMTWNH7 MI TTF2LRI DMTWNH7 MN Cathepsin B (CTSB) DMTWNH7 MT DTT DMTWNH7 MA Inhibitor DMTWNH7 RN Azapeptides structurally based upon inhibitory sites of cystatins as potent and selective inhibitors of cysteine proteases. J Med Chem. 2002 Sep 12;45(19):4202-11. DMTWNH7 RU https://pubmed.ncbi.nlm.nih.gov/12213061 DMTWNH7 DI DMTWNH7 DMTWNH7 DN Z-Arg-Leu-Val-Agly-Val-Ala-NH2 DMTWNH7 MI TTDZN01 DMTWNH7 MN Cathepsin K (CTSK) DMTWNH7 MT DTT DMTWNH7 MA Inhibitor DMTWNH7 RN Azapeptides structurally based upon inhibitory sites of cystatins as potent and selective inhibitors of cysteine proteases. J Med Chem. 2002 Sep 12;45(19):4202-11. DMTWNH7 RU https://pubmed.ncbi.nlm.nih.gov/12213061 DMLI8GZ DI DMLI8GZ DMLI8GZ DN ZD1604 DMLI8GZ MI TTU6BFZ DMLI8GZ MN Candida Thymidylate synthase (Candi TMP1) DMLI8GZ MT DTT DMLI8GZ MA Inhibitor DMLI8GZ RN Acquisition of resistance to anticancer agents by overproduction of target enzymes. Nippon Rinsho. 1997 May;55(5):1030-7. DMLI8GZ RU https://pubmed.ncbi.nlm.nih.gov/9155148 DM8MXS6 DI DM8MXS6 DM8MXS6 DN ZD-6021 DM8MXS6 MI TTYO0A3 DM8MXS6 MN Substance-K receptor (TACR2) DM8MXS6 MT DTT DM8MXS6 MA Modulator DM8MXS6 RN Pharmacological characterization of ZD6021: a novel, orally active antagonist of the tachykinin receptors. J Pharmacol Exp Ther. 2001 Jul;298(1):307-15. DM8MXS6 RU https://www.ncbi.nlm.nih.gov/pubmed/11408556 DM8MXS6 DI DM8MXS6 DM8MXS6 DN ZD-6021 DM8MXS6 MI TTZPO1L DM8MXS6 MN Substance-P receptor (TACR1) DM8MXS6 MT DTT DM8MXS6 MA Modulator DM8MXS6 RN Pharmacological characterization of ZD6021: a novel, orally active antagonist of the tachykinin receptors. J Pharmacol Exp Ther. 2001 Jul;298(1):307-15. DM8MXS6 RU https://www.ncbi.nlm.nih.gov/pubmed/11408556 DMI5WF1 DI DMI5WF1 DMI5WF1 DN ZEARALANONE DMI5WF1 MI TT78R5H DMI5WF1 MN Heat shock protein 90 alpha (HSP90A) DMI5WF1 MT DTT DMI5WF1 MA Inhibitor DMI5WF1 RN In silico identification and biochemical evaluation of novel inhibitors of NRH:quinone oxidoreductase 2 (NQO2). Bioorg Med Chem Lett. 2010 Dec 15;20(24):7331-6. DMI5WF1 RU https://pubmed.ncbi.nlm.nih.gov/21074425 DMF0CRA DI DMF0CRA DMF0CRA DN zinc pyrithione DMF0CRA MI TT846HF DMF0CRA MN Voltage-gated potassium channel Kv7.1 (KCNQ1) DMF0CRA MT DTT DMF0CRA MA Activator DMF0CRA RN Zinc pyrithione-mediated activation of voltage-gated KCNQ potassium channels rescues epileptogenic mutants. Nat Chem Biol. 2007 May;3(5):287-96. DMF0CRA RU https://pubmed.ncbi.nlm.nih.gov/17435769 DMF0CRA DI DMF0CRA DMF0CRA DN zinc pyrithione DMF0CRA MI TTPXI3S DMF0CRA MN Voltage-gated potassium channel Kv7.2 (KCNQ2) DMF0CRA MT DTT DMF0CRA MA Activator DMF0CRA RN Zinc pyrithione-mediated activation of voltage-gated KCNQ potassium channels rescues epileptogenic mutants. Nat Chem Biol. 2007 May;3(5):287-96. DMF0CRA RU https://pubmed.ncbi.nlm.nih.gov/17435769 DMF0CRA DI DMF0CRA DMF0CRA DN zinc pyrithione DMF0CRA MI TT8HGRW DMF0CRA MN Voltage-gated potassium channel Kv7.4 (KCNQ4) DMF0CRA MT DTT DMF0CRA MA Activator DMF0CRA RN Zinc pyrithione-mediated activation of voltage-gated KCNQ potassium channels rescues epileptogenic mutants. Nat Chem Biol. 2007 May;3(5):287-96. DMF0CRA RU https://pubmed.ncbi.nlm.nih.gov/17435769 DMF0CRA DI DMF0CRA DMF0CRA DN zinc pyrithione DMF0CRA MI TTWVL5Q DMF0CRA MN Voltage-gated potassium channel Kv7.5 (KCNQ5) DMF0CRA MT DTT DMF0CRA MA Activator DMF0CRA RN Zinc pyrithione-mediated activation of voltage-gated KCNQ potassium channels rescues epileptogenic mutants. Nat Chem Biol. 2007 May;3(5):287-96. DMF0CRA RU https://pubmed.ncbi.nlm.nih.gov/17435769 DMKETL5 DI DMKETL5 DMKETL5 DN zinterol DMKETL5 MI TTMXGCW DMKETL5 MN Adrenergic receptor beta-3 (ADRB3) DMKETL5 MT DTT DMKETL5 MA Agonist DMKETL5 RN The selectivity of beta-adrenoceptor agonists at human beta1-, beta2- and beta3-adrenoceptors. Br J Pharmacol. 2010 Jul;160(5):1048-61. DMKETL5 RU https://pubmed.ncbi.nlm.nih.gov/20590599 DMP089G DI DMP089G DMP089G DN ZK 756326 DMP089G MI TTE836A DMP089G MN C-C chemokine receptor type 8 (CCR8) DMP089G MT DTT DMP089G MA Agonist DMP089G RN Identification and characterization of a potent, selective nonpeptide agonist of the CC chemokine receptor CCR8. Mol Pharmacol. 2006 Jan;69(1):309-16. DMP089G RU https://pubmed.ncbi.nlm.nih.gov/16221874 DMY3SUZ DI DMY3SUZ DMY3SUZ DN ZK110841 DMY3SUZ MI TTNVEIR DMY3SUZ MN Prostaglandin D2 receptor (PTGDR) DMY3SUZ MT DTT DMY3SUZ MA Agonist DMY3SUZ RN Characterization of the recombinant human prostanoid DP receptor and identification of L-644,698, a novel selective DP agonist. Br J Pharmacol. 1998 Apr;123(7):1317-24. DMY3SUZ RU https://pubmed.ncbi.nlm.nih.gov/9579725 DMY3SUZ DI DMY3SUZ DMY3SUZ DN ZK110841 DMY3SUZ MI TTG1QMU DMY3SUZ MN Prostaglandin E2 receptor EP1 (PTGER1) DMY3SUZ MT DTT DMY3SUZ MA Agonist DMY3SUZ RN Cloned human EP1 prostanoid receptor pharmacology characterized using radioligand binding techniques. J Pharm Pharmacol. 2002 Apr;54(4):539-47. DMY3SUZ RU https://pubmed.ncbi.nlm.nih.gov/11999132 DM8JN45 DI DM8JN45 DM8JN45 DN ZK-112993 DM8JN45 MI TTUV8G9 DM8JN45 MN Progesterone receptor (PGR) DM8JN45 MT DTT DM8JN45 MA Modulator DM8JN45 RN Tumor-inhibiting potential of ZK 112.993, a new progesterone antagonist, in hormone-sensitive, experimental rodent and human mammary tumors.Anticancer Res.1990 May-Jun;10(3):683-7. DM8JN45 RU https://www.ncbi.nlm.nih.gov/pubmed/2369083 DMBCPKE DI DMBCPKE DMBCPKE DN ZK-114043 DMBCPKE MI TTUV8G9 DMBCPKE MN Progesterone receptor (PGR) DMBCPKE MT DTT DMBCPKE MA Modulator DMBCPKE RN Progesterone inhibits glucocorticoid-dependent aromatase induction in human adipose fibroblasts. J Endocrinol. 1998 Sep;158(3):401-7. DMBCPKE RU https://www.ncbi.nlm.nih.gov/pubmed/9846169 DMCQYBE DI DMCQYBE DMCQYBE DN ZK-136798 DMCQYBE MI TTUV8G9 DMCQYBE MN Progesterone receptor (PGR) DMCQYBE MT DTT DMCQYBE MA Modulator DMCQYBE RN The antiovulatory activity of progesterone antagonists is not correlated to their antiprogestational potency in the rat. J Steroid Biochem Mol Biol. 1996 Sep;59(1):75-82. DMCQYBE RU https://www.ncbi.nlm.nih.gov/pubmed/9009240 DMNMD0J DI DMNMD0J DMNMD0J DN ZK-158252 DMNMD0J MI TTVJX54 DMNMD0J MN Leukotriene B4 receptor 2 (LTB4R2) DMNMD0J MT DTT DMNMD0J MA Antagonist DMNMD0J RN Hydroxyeicosanoids bind to and activate the low affinity leukotriene B4 receptor, BLT2. J Biol Chem. 2001 Apr 13;276(15):12454-9. DMNMD0J RU https://pubmed.ncbi.nlm.nih.gov/11278893 DMYRHK6 DI DMYRHK6 DMYRHK6 DN ZK159222 DMYRHK6 MI TTK59TV DMYRHK6 MN Vitamin D3 receptor (VDR) DMYRHK6 MT DTT DMYRHK6 MA Antagonist DMYRHK6 RN Carboxylic ester antagonists of 1alpha,25-dihydroxyvitamin D(3) show cell-specific actions. Chem Biol. 2000 Nov;7(11):885-94. DMYRHK6 RU https://pubmed.ncbi.nlm.nih.gov/11094341 DMROWV8 DI DMROWV8 DMROWV8 DN ZK-164015 DMROWV8 MI TTZAYWL DMROWV8 MN Estrogen receptor (ESR) DMROWV8 MT DTT DMROWV8 MA Inhibitor DMROWV8 RN Synthesis and biological evaluation of stilbene-based pure estrogen antagonists. Bioorg Med Chem Lett. 2004 Sep 20;14(18):4659-63. DMROWV8 RU https://pubmed.ncbi.nlm.nih.gov/15324884 DMROWV8 DI DMROWV8 DMROWV8 DN ZK-164015 DMROWV8 MI TTOM3J0 DMROWV8 MN Estrogen receptor beta (ESR2) DMROWV8 MT DTT DMROWV8 MA Inhibitor DMROWV8 RN Synthesis and biological evaluation of stilbene-based pure estrogen antagonists. Bioorg Med Chem Lett. 2004 Sep 20;14(18):4659-63. DMROWV8 RU https://pubmed.ncbi.nlm.nih.gov/15324884 DMNOWAQ DI DMNOWAQ DMNOWAQ DN ZK-810388 DMNOWAQ MI TTCIHJA DMNOWAQ MN Coagulation factor Xa (F10) DMNOWAQ MT DTT DMNOWAQ MA Inhibitor DMNOWAQ RN Thiophene-anthranilamides as highly potent and orally available factor Xa inhibitors. J Med Chem. 2007 Jun 28;50(13):2967-80. DMNOWAQ RU https://pubmed.ncbi.nlm.nih.gov/17536795 DMNOWAQ DI DMNOWAQ DMNOWAQ DN ZK-810388 DMNOWAQ MI TTMF8H9 DMNOWAQ MN Plasma kallikrein (KLKB1) DMNOWAQ MT DTT DMNOWAQ MA Inhibitor DMNOWAQ RN Thiophene-anthranilamides as highly potent and orally available factor Xa inhibitors. J Med Chem. 2007 Jun 28;50(13):2967-80. DMNOWAQ RU https://pubmed.ncbi.nlm.nih.gov/17536795 DMIC4HJ DI DMIC4HJ DMIC4HJ DN ZK-813039 DMIC4HJ MI TTCIHJA DMIC4HJ MN Coagulation factor Xa (F10) DMIC4HJ MT DTT DMIC4HJ MA Modulator DMIC4HJ RN Thiophene-anthranilamides as highly potent and orally available factor Xa inhibitors. J Med Chem. 2007 Jun 28;50(13):2967-80. DMIC4HJ RU https://pubmed.ncbi.nlm.nih.gov/17536795 DMCBV5F DI DMCBV5F DMCBV5F DN ZK-814048 DMCBV5F MI TTCIHJA DMCBV5F MN Coagulation factor Xa (F10) DMCBV5F MT DTT DMCBV5F MA Inhibitor DMCBV5F RN Thiophene-anthranilamides as highly potent and orally available factor Xa inhibitors. J Med Chem. 2007 Jun 28;50(13):2967-80. DMCBV5F RU https://pubmed.ncbi.nlm.nih.gov/17536795 DMCBV5F DI DMCBV5F DMCBV5F DN ZK-814048 DMCBV5F MI TTPLTSQ DMCBV5F MN Neutrophil elastase (NE) DMCBV5F MT DTT DMCBV5F MA Inhibitor DMCBV5F RN Thiophene-anthranilamides as highly potent and orally available factor Xa inhibitors. J Med Chem. 2007 Jun 28;50(13):2967-80. DMCBV5F RU https://pubmed.ncbi.nlm.nih.gov/17536795 DMCBV5F DI DMCBV5F DMCBV5F DN ZK-814048 DMCBV5F MI TTMF8H9 DMCBV5F MN Plasma kallikrein (KLKB1) DMCBV5F MT DTT DMCBV5F MA Inhibitor DMCBV5F RN Thiophene-anthranilamides as highly potent and orally available factor Xa inhibitors. J Med Chem. 2007 Jun 28;50(13):2967-80. DMCBV5F RU https://pubmed.ncbi.nlm.nih.gov/17536795 DM24OIX DI DM24OIX DM24OIX DN ZL006 DM24OIX MI TTMADVT DM24OIX MN PSD95-nNOS interaction (PSD95-nNOS PPI) DM24OIX MT DTT DM24OIX MA Disrupter DM24OIX RN PSD95 and nNOS interaction as a novel molecular target to modulate conditioned fear: relevance to PTSD.Transl Psychiatry. 2018 Aug 14;8(1):155. DM24OIX RU https://pubmed.ncbi.nlm.nih.gov/30108200 DMEFHQI DI DMEFHQI DMEFHQI DN Z-LEHD-fmk DMEFHQI MI TTB6T7O DMEFHQI MN Caspase-9 (CASP9) DMEFHQI MT DTT DMEFHQI MA Inhibitor DMEFHQI RN The expression of Smac and XIAP in rat hippocampus following limbic seizure induced by kainic acid injection into amygdaloid nucleus. Sheng Li Xue Bao. 2004 Apr 25;56(2):172-7. DMEFHQI RU https://pubmed.ncbi.nlm.nih.gov/15127126 DM6OGR9 DI DM6OGR9 DM6OGR9 DN Z-leu-Val-Agly-Val-OBzl DM6OGR9 MI TTF2LRI DM6OGR9 MN Cathepsin B (CTSB) DM6OGR9 MT DTT DM6OGR9 MA Inhibitor DM6OGR9 RN Azapeptides structurally based upon inhibitory sites of cystatins as potent and selective inhibitors of cysteine proteases. J Med Chem. 2002 Sep 12;45(19):4202-11. DM6OGR9 RU https://pubmed.ncbi.nlm.nih.gov/12213061 DM6OGR9 DI DM6OGR9 DM6OGR9 DN Z-leu-Val-Agly-Val-OBzl DM6OGR9 MI TTDZN01 DM6OGR9 MN Cathepsin K (CTSK) DM6OGR9 MT DTT DM6OGR9 MA Inhibitor DM6OGR9 RN Azapeptides structurally based upon inhibitory sites of cystatins as potent and selective inhibitors of cysteine proteases. J Med Chem. 2002 Sep 12;45(19):4202-11. DM6OGR9 RU https://pubmed.ncbi.nlm.nih.gov/12213061 DM1H865 DI DM1H865 DM1H865 DN ZL-N-91 DM1H865 MI TTZ97H5 DM1H865 MN Phosphodiesterase 4A (PDE4A) DM1H865 MT DTT DM1H865 MA Inhibitor DM1H865 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1300). DM1H865 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1300 DM1H865 DI DM1H865 DM1H865 DN ZL-N-91 DM1H865 MI TTVIAT9 DM1H865 MN Phosphodiesterase 4B (PDE4B) DM1H865 MT DTT DM1H865 MA Modulator DM1H865 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1301). DM1H865 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1301 DM1H865 DI DM1H865 DM1H865 DN ZL-N-91 DM1H865 MI TTSKMI8 DM1H865 MN Phosphodiesterase 4D (PDE4D) DM1H865 MT DTT DM1H865 MA Modulator DM1H865 RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1303). DM1H865 RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1303 DMA3M9H DI DMA3M9H DMA3M9H DN ZM 253270 DMA3M9H MI TTYO0A3 DMA3M9H MN Substance-K receptor (TACR2) DMA3M9H MT DTT DMA3M9H MA Antagonist DMA3M9H RN Pharmacological characterization of a new class of nonpeptide neurokinin A antagonists that demonstrate species selectivity. J Pharmacol Exp Ther. 1995 Sep;274(3):1216-21. DMA3M9H RU https://pubmed.ncbi.nlm.nih.gov/7562491 DMC46RQ DI DMC46RQ DMC46RQ DN ZM 325802 DMC46RQ MI TTG1QMU DMC46RQ MN Prostaglandin E2 receptor EP1 (PTGER1) DMC46RQ MT DTT DMC46RQ MA Modulator DMC46RQ RN Characterization of the prostanoid receptor types involved in mediating calcitonin gene-related peptide release from cultured rat trigeminal neurones. Br J Pharmacol. 2001 Nov;134(6):1296-302. DMC46RQ RU https://www.ncbi.nlm.nih.gov/pubmed/11704650 DMD0NFL DI DMD0NFL DMD0NFL DN ZM-274773 DMD0NFL MI TTYO0A3 DMD0NFL MN Substance-K receptor (TACR2) DMD0NFL MT DTT DMD0NFL MA Antagonist DMD0NFL RN Tachykinin NK2 receptor antagonists. A patent review (2006 - 2010). Expert Opin Ther Pat. 2012 Jan;22(1):57-77. DMD0NFL RU https://pubmed.ncbi.nlm.nih.gov/22149761 DMD5JYQ DI DMD5JYQ DMD5JYQ DN ZM-336372 DMD5JYQ MI TT0EOB8 DMD5JYQ MN B-Raf messenger RNA (BRAF mRNA) DMD5JYQ MT DTT DMD5JYQ MA Inhibitor DMD5JYQ RN The selectivity of protein kinase inhibitors: a further update. Biochem J. 2007 Dec 15;408(3):297-315. DMD5JYQ RU https://pubmed.ncbi.nlm.nih.gov/17850214 DMD5JYQ DI DMD5JYQ DMD5JYQ DN ZM-336372 DMD5JYQ MI TT860QF DMD5JYQ MN LCK tyrosine protein kinase (LCK) DMD5JYQ MT DTT DMD5JYQ MA Inhibitor DMD5JYQ RN The selectivity of protein kinase inhibitors: a further update. Biochem J. 2007 Dec 15;408(3):297-315. DMD5JYQ RU https://pubmed.ncbi.nlm.nih.gov/17850214 DMD5JYQ DI DMD5JYQ DMD5JYQ DN ZM-336372 DMD5JYQ MI TTAN5W2 DMD5JYQ MN Raf messenger RNA (Raf mRNA) DMD5JYQ MT DTT DMD5JYQ MA Inhibitor DMD5JYQ RN The selectivity of protein kinase inhibitors: a further update. Biochem J. 2007 Dec 15;408(3):297-315. DMD5JYQ RU https://pubmed.ncbi.nlm.nih.gov/17850214 DMD5JYQ DI DMD5JYQ DMD5JYQ DN ZM-336372 DMD5JYQ MI TTQBR95 DMD5JYQ MN Stress-activated protein kinase 2a (p38 alpha) DMD5JYQ MT DTT DMD5JYQ MA Inhibitor DMD5JYQ RN A novel series of p38 MAP kinase inhibitors for the potential treatment of rheumatoid arthritis. Bioorg Med Chem Lett. 2004 Nov 1;14(21):5383-7. DMD5JYQ RU https://pubmed.ncbi.nlm.nih.gov/15454231 DMTMVYH DI DMTMVYH DMTMVYH DN ZM-39923 DMTMVYH MI TT6DM01 DMTMVYH MN Janus kinase 1 (JAK-1) DMTMVYH MT DTT DMTMVYH MA Inhibitor DMTMVYH RN Naphthyl ketones: a new class of Janus kinase 3 inhibitors. Bioorg Med Chem Lett. 2000 Mar 20;10(6):575-9. DMTMVYH RU https://pubmed.ncbi.nlm.nih.gov/10741557 DMTMVYH DI DMTMVYH DMTMVYH DN ZM-39923 DMTMVYH MI TTT7PJU DMTMVYH MN Janus kinase 3 (JAK-3) DMTMVYH MT DTT DMTMVYH MA Inhibitor DMTMVYH RN Naphthyl ketones: a new class of Janus kinase 3 inhibitors. Bioorg Med Chem Lett. 2000 Mar 20;10(6):575-9. DMTMVYH RU https://pubmed.ncbi.nlm.nih.gov/10741557 DMFP8WE DI DMFP8WE DMFP8WE DN ZM-447439 DMFP8WE MI TTPS3C0 DMFP8WE MN Aurora kinase A (AURKA) DMFP8WE MT DTT DMFP8WE MA Inhibitor DMFP8WE RN Accurate prediction of the relative potencies of members of a series of kinase inhibitors using molecular docking and MM-GBSA scoring. J Med Chem. 2006 Aug 10;49(16):4805-8. DMFP8WE RU https://pubmed.ncbi.nlm.nih.gov/16884290 DMEC1I9 DI DMEC1I9 DMEC1I9 DN Zn2+ DMEC1I9 MI TTI0TCK DMEC1I9 MN Mycobacterium CDP-diacylglycerol-inositol phosphatidyltransferase (MycB pssA) DMEC1I9 MT DTT DMEC1I9 MA Inhibitor DMEC1I9 RN Phosphatidylinositol synthesis in mycobacteria. Biochim Biophys Acta. 1999 Jan 4;1436(3):437-50. DMEC1I9 RU https://pubmed.ncbi.nlm.nih.gov/9989274 DMY2V37 DI DMY2V37 DMY2V37 DN ZNCCNCSSKWCRDHSRCC DMY2V37 MI TT84DRB DMY2V37 MN Voltage-gated sodium channel alpha Nav1.4 (SCN4A) DMY2V37 MT DTT DMY2V37 MA Inhibitor DMY2V37 RN Structure/function characterization of micro-conotoxin KIIIA, an analgesic, nearly irreversible blocker of mammalian neuronal sodium channels. J Biol Chem. 2007 Oct 19;282(42):30699-706. DMY2V37 RU https://pubmed.ncbi.nlm.nih.gov/17724025 DM8WRAU DI DM8WRAU DM8WRAU DN ZP-2307 DM8WRAU MI TTEPJL5 DM8WRAU MN Parathyroid hormone receptor (PTH2R) DM8WRAU MT DTT DM8WRAU MA Modulator DM8WRAU RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 332). DM8WRAU RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=332 DMJ16AD DI DMJ16AD DMJ16AD DN ZP-3022 DMJ16AD MI TTVIMDE DMJ16AD MN Glucagon-like peptide 1 receptor (GLP1R) DMJ16AD MT DTT DMJ16AD MA Agonist DMJ16AD RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 249). DMJ16AD RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=249 DM9XFYZ DI DM9XFYZ DM9XFYZ DN ZP-G-CSF DM9XFYZ MI TTC70AJ DM9XFYZ MN Granulocyte colony-stimulating factor receptor (G-CSF-R) DM9XFYZ MT DTT DM9XFYZ MA Stimulator DM9XFYZ RN URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1719). DM9XFYZ RU http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1719 DM43O2U DI DM43O2U DM43O2U DN Z-Pro-Prolinal DM43O2U MI TTNGKET DM43O2U MN Prolyl endopeptidase (PREP) DM43O2U MT DTT DM43O2U MA Inhibitor DM43O2U RN The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. DM43O2U RU https://pubmed.ncbi.nlm.nih.gov/10592235 DM1YZJ3 DI DM1YZJ3 DM1YZJ3 DN ZRCCNCSSKWCRDHSRCC DM1YZJ3 MI TT84DRB DM1YZJ3 MN Voltage-gated sodium channel alpha Nav1.4 (SCN4A) DM1YZJ3 MT DTT DM1YZJ3 MA Inhibitor DM1YZJ3 RN Structure/function characterization of micro-conotoxin KIIIA, an analgesic, nearly irreversible blocker of mammalian neuronal sodium channels. J Biol Chem. 2007 Oct 19;282(42):30699-706. DM1YZJ3 RU https://pubmed.ncbi.nlm.nih.gov/17724025 DM60N3C DI DM60N3C DM60N3C DN ztz240 DM60N3C MI TTPXI3S DM60N3C MN Voltage-gated potassium channel Kv7.2 (KCNQ2) DM60N3C MT DTT DM60N3C MA Activator DM60N3C RN Isoform-specific prolongation of Kv7 (KCNQ) potassium channel opening mediated by new molecular determinants for drug-channel interactions. J Biol Chem. 2010 Sep 3;285(36):28322-32. DM60N3C RU https://pubmed.ncbi.nlm.nih.gov/20584905 DMCE8K1 DI DMCE8K1 DMCE8K1 DN Z-VAD-CHO DMCE8K1 MI TTCQIBE DMCE8K1 MN Caspase-1 (CASP1) DMCE8K1 MT DTT DMCE8K1 MA Inhibitor DMCE8K1 RN Tethering identifies fragment that yields potent inhibitors of human caspase-1. Bioorg Med Chem Lett. 2006 Feb;16(3):559-62. DMCE8K1 RU https://pubmed.ncbi.nlm.nih.gov/16274992 DM4Y0NI DI DM4Y0NI DM4Y0NI DN ZX-AP000068 DM4Y0NI MI DERA3OF DM4Y0NI MN Bile acid-CoA thioesterase (BAAT) DM4Y0NI MT DME DM4Y0NI MA Metabolism DM4Y0NI RN Bile acid coenzyme A: amino acid N-acyltransferase in the amino acid conjugation of bile acids. Methods Enzymol. 2005;400:374-94. DM4Y0NI RU https://www.ncbi.nlm.nih.gov/pubmed/?term=16399361 DMN9UCI DI DMN9UCI DMN9UCI DN ZY H2 DMN9UCI MI TTJ584C DMN9UCI MN Peroxisome proliferator-activated receptor alpha (PPARA) DMN9UCI MT DTT DMN9UCI MA Modulator DMN9UCI RN The ChEMBL database in 2017. Nucleic Acids Res. 2017 Jan 4;45(D1):D945-D954. DMN9UCI RU https://www.ncbi.nlm.nih.gov/pubmed/27899562 DMN9UCI DI DMN9UCI DMN9UCI DN ZY H2 DMN9UCI MI TTZMAO3 DMN9UCI MN Peroxisome proliferator-activated receptor gamma (PPAR-gamma) DMN9UCI MT DTT DMN9UCI MA Modulator DMN9UCI RN The ChEMBL database in 2017. Nucleic Acids Res. 2017 Jan 4;45(D1):D945-D954. DMN9UCI RU https://www.ncbi.nlm.nih.gov/pubmed/27899562 DM0S5PE DI DM0S5PE DM0S5PE DN ZYKLOPHIN DM0S5PE MI TTQW87Y DM0S5PE MN Opioid receptor kappa (OPRK1) DM0S5PE MT DTT DM0S5PE MA Inhibitor DM0S5PE RN The effects of C-terminal modifications on the opioid activity of [N-benzylTyr(1)]dynorphin A-(1-11) analogues. J Med Chem. 2009 Nov 12;52(21):6814-21. DM0S5PE RU https://pubmed.ncbi.nlm.nih.gov/19807094 DM0S5PE DI DM0S5PE DM0S5PE DN ZYKLOPHIN DM0S5PE MI TTKWM86 DM0S5PE MN Opioid receptor mu (MOP) DM0S5PE MT DTT DM0S5PE MA Inhibitor DM0S5PE RN The effects of C-terminal modifications on the opioid activity of [N-benzylTyr(1)]dynorphin A-(1-11) analogues. J Med Chem. 2009 Nov 12;52(21):6814-21. DM0S5PE RU https://pubmed.ncbi.nlm.nih.gov/19807094 DM0TP2R DI DM0TP2R DM0TP2R DN Z-YVAD-CHO DM0TP2R MI TTCQIBE DM0TP2R MN Caspase-1 (CASP1) DM0TP2R MT DTT DM0TP2R MA Inhibitor DM0TP2R RN Tethering identifies fragment that yields potent inhibitors of human caspase-1. Bioorg Med Chem Lett. 2006 Feb;16(3):559-62. DM0TP2R RU https://pubmed.ncbi.nlm.nih.gov/16274992 DMFTBPI DI DMFTBPI DMFTBPI DN Z-YVAD-FMK DMFTBPI MI TTCQIBE DMFTBPI MN Caspase-1 (CASP1) DMFTBPI MT DTT DMFTBPI MA Inhibitor DMFTBPI RN Different molecular events account for butyrate-induced apoptosis in two human colon cancer cell lines. J Nutr. 2002 Jul;132(7):1812-8. DMFTBPI RU https://pubmed.ncbi.nlm.nih.gov/12097652